bluuebunny/crossref_metadata_2025 huggingface dataset:
Interprofessional collaboration and associated factors among nurses and physicians working at public hospitals in Mekelle city tigray region, north Ethiopia, 2017
Authors: Eukubay Teklit , Abate Abebe
Published: March 2023

Background: Inter professional collaboration is necessary to ensure that health care teams are efficient and able to provide collaboration, and joint decision making between the client and the health care teams in all areas of treatment planning and caring clients with the highest quality of care, in order to reach a determined goal, regardless of the health care settings. Objective: To assess inter-professional collaboration and associated factors among nurses and physicians working in public hospitals at Mekelle town Tigray Northern Ethiopia 2017. Method: Institution based of quantitative cross sectional study design was conducted among 409 study participants were selected by simple random sampling techniques from all public hospitals of Mekelle city. The data were presented in the form of text, frequencies, tables and figures Logistic regression was used to test association between dependent and independent variables. All variables with P value≤0.25 were including in multivariable analysis and magnitude of association measured by using odds ratio at 95% confidence interval and statistically significant at p-value less than 0.05 was considered statically significant. Result: This study indicates that more than half 222(54.3%) respondents were shows frequent collaborations. The determinants factors showed that unfavorable attitude of shared education and teamwork statistically significant associated 2.53 times higher for infrequent collaboration among those who has favorable attitude (AOR 2.53, 95% CI (1.44-4.45). Poor Communication showed associated 3.73 times higher for infrequent collaboration compared with respondents has good communication (AOR, 3.73, 95% CI (2.30-6.05).Similarly dissatisfied by organizational supports showed significant associated 2.94 times for infrequent collaboration which compared with respondents satisfied by organizational support (AOR 2.94 at 95% CI (1.83-4.73). Conclusion: The finding of this study was reasonably good and this was caused by jointly collaborated professional activities but still it needs improvements. Organizational supports of professional growth, motivations and recognitions, taking responsibility, early conflict managements were pertinent factors to increase professional satisfaction, mutual understanding and collaborative practice.
Effectiveness of structured teaching programme on knowledge and practice regarding first aid management of selected minor injuries among
Authors: Joys Rinu , Anto Tresa , a Angel , Ann Joseph G suja , John Jaicy
Published: March 2023

Objectives: The study was conducted to assess the effectiveness of structured teaching programme on knowledge and practice regarding first aid management of selected minor injuries among adolescents. Materials and methods: Quantitative evaluative approach was used with Quasi experimental, one group pre-test post-test design Results: nearly half 41.66% of the samples belong to 8th and 9th class, 39.16% of mothers were unemployed, 49.16% of the fathers had primary education, 40.83% of adolescents were having a monthly income ≤2300Rs. Significant increase was found in mean post-test knowledge score (24.09±2.04,t119=67.7 at p<0.001)and post-test practice score(24.4±1.91, t119=77.0 at p<0.001) after teaching through lecturing and demonstration. Conclusion: structured teaching programme on first aid measures for selected minor injuries was effective in enhancing the level of knowledge and practice of adolescents.
Management dilemma of multiple submucous fibroids in "virgo intacta”
Authors: Anyanwu Matthew , Alex Victoria , Sanyang Amadou , Chibili Njingu , Faburay Fatou , Kanyi Foday
Published: March 2023

Nulliparity and advanced age are dependent risk factors of uterine fibroids in the reproductive life of every woman. Fertility-sparing treatment options remain the mainstay of management where there is fertility desire. We present a case report of a 42-year-old Virgo intacta who had abnormal uterine bleeding due to multiple submucous fibroids. An open myomectomy was performed and she made good recovery. Combined oral contraceptive pills were commenced immediately after the operation and continued for 3 months. She had regular periodic bleeding of low volume, flow and duration. Thereafter, subsequent monthly follow-ups were uneventful as a normal regular menstrual cycle was restored. There were management challenges as she was Virgo intacta at 42 years of age. Measures to avoid intrauterine synechiae were limited and combined oral contraceptive was used with good outcome.
Autologous fascial slings – efficacy and future challenges. An analytic review
Authors: Sofoudis Chrisostomos , Theodoros Stouras Vaios , Panagiotis Filios
Published: March 2023

Stress urinary incontinence (SUI) consists a clinical entity affecting approximately 1/3 of women worldwide. Therefore, management and therapeutic mapping should be planned assiduously. Surgical treatment for SUI has been an optimal surgical intervention for over 50 years, beginning from Burch colposuspension and Kelly’s plication, to midurethral slings, tension free vaginal tapes, trans obturator tapes and autologous fascial slings. Even though synthetic midurethral slings represented the most common surgical approach since the mid 90’s, due to their minimally invasive character, nowadays, lots of concerns have been raised among medical community concerning their serious long-term complications such as, mesh erosion, vaginal extrusion, urethral erosion and injury, groin, thigh or pelvic pain, recurrent infections and dyspareunia. These complications forced FDA (Food and Drug Administration) to issue a warning against their use, leading the implementation concerning autologous facial slings come back in to the surface. Despite the fact that the use of autologous fascial slings depicts a more invasive and challenging approach to treat SUI, there are notably more benefits regarding postoperative outcome, as well as decreased rate of potential complications when compared to TVT (Tension-free Vaginal Tape) and TOT (Trans Obturator Tape). Although, more trials and data must be conducted in order to be considered as main approach. Aim of this analytic review consists efficacy’s depiction of the autologous fascial slings according to recent bibliography and the role they could play in the near future concerning optimal therapeutic strategy of SUI.
Про нафтогазоносність Карпатського регіону України
Authors: Муровська Ганна Валеріївна
Published: March 2023

У доповіді зазначено, що відродження Карпатського нафтогазоносного регіону завдяки нарощуванню в ньому парку нових родовищ нафти і газу може значною мірою сприяти досягненню енергетичної незалежності України. В Інституті геофізики ім. С.І. Субботіна НАН України активно розвиваються наукові дослідження з вивчення глибинної будови літосфери геолого-геофізичними методами. Зокрема, з метою виявлення нафтогазоносності методом глибинного сейсмічного зондування детально вивчається глибинна будова Закарпатського прогину, в надрах якого, за попередніми даними, на глибинах 5—17 км можуть бути потужні резервуари вуглеводнів.
Проблема історичної пам’яті: європейський дискурс (1945—2020 рр.)
Authors: Кудряченко Андрій Іванович
Published: March 2023

У доповіді зазначено, що Європа і світ загалом на початку ХХІ ст. переживають значні політичні, економічні, екологічні, соціальні та духовні зміни. В останні десятиліття людство зіштовхнулося з цілою низкою безпрецедентних глобальних викликів, пов’язаних, зокрема, з проблемами виживання, системної трансформації, модернізаційного та цивілізаційного розвитку. Відтак, соціально затребуваними сьогодні стали історичні студії, які охоплюють усе зростаючий спектр тематики історичної пам’яті про минуле як утвердження одного з ключових концептів «нового історицизму», що збігається зі становленням нової культурної історії, яка стала відповіддю на різні виклики постмодерну.
Досягнення та перспективи розвитку генно-інженерних рослинних біотехнологій
Authors: Кучук Микола Вікторович
Published: March 2023

У доповіді наведено результати фундаментальних та прикладних наукових досліджень Інституту клітинної біології та генетичної інженерії НАН України, спрямованих на розвиток рослинних біотехнологій для аграрного сектору економіки та фармацевтики, зокрема на створення біотехнологічних рослин сільськогосподарського та медичного призначення.
Творець хлібного достатку України — вагомої складової національної безпеки держави
Authors: Коць Сергій Ярославович
Published: March 2023

10 березня виповнилося 85 років видатному українському вченому-генетику, селекціонеру рослин, Герою України (2008), лауреату Державних премій у галузі науки і техніки СРСР (1986), УРСР (1982) та України (1997), заслуженому діячеві науки і техніки (1998), лауреату Золотої медалі імені В.І. Вернадського (2017) і премії імені В.Я. Юр’єва (1993) НАН України, директору Інституту фізіології рослин і генетики НАН України (з 1986), доктору біологічних наук (1980), професору (1988), академіку НАН України (1990) Володимиру Васильовичу Моргуну.
Tugging at Heartstrings
Authors: Schneller Tom , Motazedian Táhirih
Published: March 2023

The love theme is one of the central musicodramatic topics of classic Hollywood music but, thus far, little scholarly attention has been paid to the specific musical devices used by film composers to depict love. To the extent that musical analysis has entered the picture at all, it has tended to focus on the motivic level, despite the fact that much of the emotional alchemy of film music resides in its harmonic structure. This is particularly true for classic Hollywood love themes, which often draw on subtle chromatic inflections to weave their affective spells. In this article, we will address two particular harmonic schemas associated with romance during the studio era: (1) the Heartstring schema, which involves the inflection of a major tonic by a chromatic chord usually centered on b6^, and (2) the downstep modulation, a variant of the circle-of-fifths sequence. Both schemas rely on the bittersweet frisson between major and minor modes, a tension that contributes significantly to the emotional punch still packed by the great love themes of Hollywood’s Golden Age.
Peter Franklin, Seeing Through Music: Gender and Modernism in Classical Hollywood Film Scores
Authors: Getman Jessica
Published: March 2023

Peter Franklin, Seeing Through Music: Gender and Modernism in Classical Hollywood Film Scores Oxford: Oxford University Press, 2011 [208pp. ISBN: 9780195383454. £46.99 (hardback); ISBN: 9780190246549. £31.49 (paperback)], 28 screen stills, index.
New Surprises for Haydn’s Surprise Symphony
Authors: Lyon Jeff , Yorgason Brent
Published: March 2023

In his score to the 1939 film We Are Not Alone, Max Steiner uses the melody from the second movement of Joseph Haydn’s Surprise Symphony forty-one times to represent different situations, places, emotions, and character development for Dr. David Newcome, played by Paul Muni. In each variation, Steiner adds an extra “surprise” to the theme. These variations include the use of dark textures, mode changes, reharmonization, chromaticism, meter changes, melodic variation, and the orchestration of diegetic music.
Fractured Reasons and Fractured Reason in I Walked with a Zombie
Authors: Lee Michael , Reichardt Ellis Sarah
Published: March 2023

I Walked with a Zombie, a poetic horror film from 1943, enjoys widespread and intense admiration of a sort rarely bestowed on a “B” horror film from the studio era. Robin Wood (2003) sees the film as the genre’s finest and has observed that its treatment of the genre’s signal dichotomy of Superstition vs. Reason results in a series of expressive doublings within the film. This article amplifies Wood’s admiration by examining the film’s approach to music. Its soundtrack features the work of two composers. RKO’s Roy Webb offers the Western perspective of Reason while Haitian musician LeRoy Antoine provides the Caribbean perspective associated with Voodooism. By looking at the musical doublings in the film, this article argues that music functions in the film to further dismantle the posture of Reason. This film, more than any the author can think of from the era, criticizes the colonial project and dismantles the Western notion that any single perspective or explanatory model can lead to a sufficient understanding of human affairs.
Making Space for Music
Authors: Platte Nathan
Published: March 2023

Max Steiner met Robert Wise, future director of West Side Story (1961) and The Sound of Music (1965), at RKO in the early 1930s. While Steiner served as composer and music director for films like Of Human Bondage (1934), The Gay Divorcee (1934), The Informer (1935), and Top Hat (1935), Wise helped manage the soundtrack as an assistant sound and music editor. After Steiner left RKO in early 1936, Wise stayed on at the studio to advance through the ranks of film editor and director before reuniting with Steiner at Warner Bros. for the melodrama So Big (1953) and sword-and-sandals epic Helen of Troy (1956).
Drawing on original archival research, this article reconstructs a partnership that briefly flourished at different stages of their careers. At RKO, Wise learned the trade while observing Steiner’s ground-breaking efforts as a composer. By the 1950s Wise was rapidly growing in renown as a director, as signaled by his assignment to the generously budgeted Helen of Troy. In contrast, Steiner faced pay cuts and the termination of his contract at Warner Bros. Steiner’s two productions with Wise boosted Steiner’s lagging career while also illuminating the ways in which shifting aesthetics and production practices in Hollywood had left Steiner at a disadvantage. Whereas So Big represented a throwback to films like Cimarron, which Steiner had scored at RKO in 1931 (both based on Edna Ferber novels), Helen of Troy marked a new emphasis on visual and aural spectacle, with an epic narrative told through CinemaScope, stereophonic sound, and a cast of thousands. Writings on director-composer partnerships tend to emphasize the formation of a distinctive sonic style, in the manner of Alfred Hitchcock and Bernard Herrmann. Steiner and Wise, in contrast, were consummate studio employees, eager to serve productions that ranged widely in topic, genre, and budget. Studying their brief partnership in the 1950s reveals how two individuals well versed in the workings of the Hollywood studio system managed to help each other navigate its dismantling in the 1950s.
Corpus linguistics and historiography
Authors: Berber Sardinha Tony
Published: March 2023

This study identified and tracked the major discourses present in the first 50 years of TESOL Quarterly. A corpus of articles published in the journal was collected, tagged, and analyzed for lexical dimensions of variation (the lexical parameters underlyingvariation across texts in the journal). A factor analysis detected the sets of lexical words cooccurring in the texts. The factors were interpreted into five dimensions: (1) critical, social, cultural, discourse or identity versus language assessment and testing; (2) applications of linguistic theory versus language policy, education and planning; (3) quantitative research methods versus positivist teaching materials and techniques; (4) language teaching and learning versus word-based investigations; and (5) reading and writing versus listening and speaking. The dimension scores were entered in a cluster analysis that identified the two principal eras of the journal: the first from 1967 to the early 1990s, and the second from the early 1990s to 2016.
Measuring semantic distance across time
Authors: Pettersson-Traba Daniela
Published: March 2023

Over the last decades, several studies have analyzed the collocational preferences of particular sets of near synonyms from a synchronic viewpoint, while their diachronic development has generally been disregarded. The aim of this paper is to partially fill this gap by examining the collocational behavior of the adjectives fragrant, perfumed, and scented, which denote the concept sweet smelling, over the time span 1810–2009. To this purpose, instances of the three near-synonyms and their L5–R5 collocates were extracted from the Corpus of Historical American English (COHA) and then submitted to statistical modeling. Results indicate that, at the beginning of the time span analyzed, the collocational preferences of scented and perfumed are very similar but, over time, scented becomes semantically closer to fragrant, while at the same time taking over some of its functions.
Teaching the Japanese Aspectual form Teiru using Concept-Based Language Instruction (C-BLI) in an Intact Beginning-Level Classroom
Authors: Tsujihara Rie
Published: March 2023

The Japanese aspectual form teiru marks ‘the durative phase of a situation’ (Shirai, 2000: 333) and has four distinct meanings, progressive, resultative, perfect, and habitual. Because of the complex concepts and the polysemous nature of the structure, even advanced learners’ understanding and ability to interpret and produce appropriate teiru forms is at times fragmented and incomplete (e.g., Nishi, 2018; Shirai and Kurono, 1998; Shibata, 1999; Sugaya, 2002). This paper considers how Concept-Based Language Instruction (C-BLI) can help L2 beginning learners of Japanese, who were introduced to teiru for the first time, develop understanding of the target concept. C-BLI teaches categories of meaning and how they are connected to forms through the materialization and transformation of conceptual understandings (García, 2018; Lantolf et al., 2020). The instruction was conducted in a college-level intact first-year Japanese class for six weeks. This paper presents findings that illustrate the development of the entire class, focusing on the transformation in two focal students’ understanding and interpretations of the teiru form.
A Classroom Application of Concept-Based Language Instruction (C-BLI)
Authors: Benhamlaoui Maroua , Gánem-Gutiérrez Gabriela Adela
Published: March 2023

This study reports on an investigation of the potential of Concept Based Language Instruction (C-BLI) for enhancing EFL learners’ understanding of the concept of tense/aspect in English and their use of associated forms; past simple, past continuous, and present perfect. C-BLI was compared to a grammar presentation approach based on the Presentation-Practice-Production (PPP) model. Participants included 45 adult learners of L2 English from an Algerian University. Drawing on a pre-, post-, delayed post-test research design the study revealed the effectiveness of C-BLI over PPP for improving the participants’ understanding of the concept of tense/aspect as well as their use of the three target forms.
Marjoram oil attenuates oxidative stress and improves colonic epithelial barrier function in dextran sulfate sodium-induced ulcerative colitis in Balb/c mice
Authors: DI Bouayad , Grar Hadria , Berzou Sadia , Kheroua Omar , Saidi Djamel , Kaddouri Hanane
Published: March 2023

In this study, we explored the effects of marjoram oil (MO) on dextran sulfate sodium (DSS)-induced colitis in Balb/c mice. Marjoram oil was found to significantly reduce the severity of DSS-induced colonic inflammation, as reflected by improved disease activity index, prevented colon length shortening, lower histopathological score, decreased myeloperoxidase activity, and reduced interlukin 6 (IL-6) levels. Moreover, marjoram oil pretreatment enhanced the colonic epithelial integrity by decreasing paracellular permeability. Marjoram oil was found to clearly reduce the colonic levels of thiobarbituric acid reactive substances assay and enhance the activity of superoxide dismutase, catalase, and glutathione sulfhydryl content. Marjoram oil could exert a protective effect on ulcerative colitis through its anti-inflammatory and antioxidant properties.
Determinants of prognosis and management of patients with pulmonary hypertension due to left heart disease: a systematic review
Authors: Lyapina I. N. , Teplova Yu. E. , Martynyuk T. V.
Published: March 2023

Patients with pulmonary hypertension (PH) associated with left heart disease usually have a complex comorbidity status and a postcapillary component of PH. The presence and identification of a combined post-/precapillary PH in a cohort of patients with left heart disease is reflected in the more pronounced structural and functional right ventricular changes due to higher pulmonary vascular resistance. Patients with combined post-/ precapillary PH have reduced exercise tolerance and PH phenotype similar to pulmonary arterial hypertension. Detection of combined PH is critical as it may influence the prognosis and management of patients. This review presents modern prognosis markers for patients with PH due to left heart disease, which can be used in clinical practice. The results of randomized clinical trials and pilot studies on the expansion of treatment options in group 2 patients, including the use of PAH-specific agents, were analyzed. The prospects for the treatment of this cohort of patients are discussed.
Influence of 5-hydroxymethyluracil on the dynamics of angiogenic growth factors in the perioperative period of surgical myocardial revascularization: results of a randomized trial
Authors: Oleynik B. A. , Plechev V. V. , Evdakov V. A. , Izhbuldin R. I. , Zagidullin N. Sh.
Published: March 2023

Aim. To evaluate the effect of 5-hydroxymethyluracil on the dynamics of angiogenic growth factors in the perioperative period of surgical myocardial revascularization.

Material and methods. This prospective, randomized, single-center study included two following groups: experimental group — 25 patients in the perioperative period of coronary artery bypass grafting (5 days before and 14 days after surgery) receiving 5-hydroxymethyluracil (at a dose of 500 mg 3 times a day) in addition to standard therapy; control group — 25 patients receiving standard therapy. The groups were comparable in terms of sex, age, main clinical and functional characteristics and features of surgical intervention. In patients, quantitative indicators of angiogenic growth factors in peripheral blood taken 5 days before and 14 days after surgery were studied by enzyme immunoassay: human vascular endothelial growth factor A (VEGF-A), human hepatocyte growth factor (hHGF), insulin-like factor growth 1 (IGF-1) and basic fibroblast growth factor (bFGF).

Results. In the experimental group of patients, while taking 5-hydroxymethyluracil, there was a significant increase in the peripheral blood concentration of following growth factors compared with the control group: VEGF-A by 26,90% (p=0,0246), IGF-1 by 44,89% (p=0,0011), bFGF by 60,0% (p=0,0006). The hHGF concentration also turned out to be higher by 19,90%, but did not reach the level of statistical significance (p=0,2836).

Conclusion. The use of 5-hydroxymethyluracil, a representative of pyrimidines, in the perioperative period of surgical myocardial revascularization leads to a significant increase in peripheral blood of such angiogenic growth factors as VEGF-A, IGF-1, and bFGF.
Red flags to diagnose infiltrative cardiomyopathies
Authors: Reznik E. V. , Nguyen T. L. , Ustyuzhanin D. V. , Semyachkina A. N. , Shkolnikova M. A.
Published: March 2023

Infiltrative cardiomyopathies are a group of diseases characterized by the deposition of abnormal substances in heart tissues, which leads to thickening of the walls or dilation of chambers with a secondary decrease in wall thickness and the development of diastolic, less often systolic, ventricular dysfunction. Most often, these are progressive diseases that, in the absence of adequate therapy, have an unfavorable prognosis. Clinical manifestations of infiltrative cardiac diseases are variable, which often leads to diagnostic difficulties and errors. In most cases, specific laboratory and morphological tests are required to confirm or clarify the diagnosis. Early diagnosis is critical to initiating therapy and improving patient prognosis. This article provides characteristic signs and symptoms, the so-called "red flags", making it possible to suspect infiltrative cardiomyopathies, diagnose them at an early stage and start life-saving therapy.
Omega-3 polyunsaturated fatty acids in the prevention of postoperative atrial fibrillation in open heart surgery: a systematic review and meta-analysis
Authors: Rubanenko O. A. , Rubanenko A. O. , Davydkin I. L.
Published: March 2023

Aim. To evaluate the literature data on the efficacy of omega-3 polyunsaturated fatty acids (PUFAs) in the prevention of postoperative atrial fibrillation (POAF) in elective cardiac surgery, including onor off-pump coronary artery bypass grafting and/or valve replacement and/or repair.

Material and methods. The search for studies was carried out using the PubMed database and Google Scholar from 2005 to January 31, 2022. From the initially identified search results, 19 articles were analyzed. The design of articles corresponded to randomized clinical trials. Omega-3 PUFAs was selected as an interventional effect. The studies were to include, as an end point, the assessment of new POAF cases in the early period after open heart surgery.

Results. The meta-analysis included 15 studies with 3980 patients, of which 1992 (50,0%) patients took omega-3 PUFAs. POAF occurred in 587 (29,5%) patients receiving omega-3 PUFAs and 679 (34,2%) patients on standard therapy (hazard ratio, 0,8, 0,68-0,93, p=0,004). There is a variation in effect size for POAF patients in the presented randomized clinical trials relative to the axis of the central trend and heterogeneity of studies with a significant number of patients included (I2=51%, p=0,01).

Conclusion. Our systematic review and meta-analysis showed the effectiveness of omega-3 PUFAs in the prevention of POAF during open heart surgery.
Prevalence of professional burnout among practicing cardiologists in the constituent entities of the Russian Federation
Authors: Neplyueva G. A. , Soloveva A. E. , Krovopolenova S. D. , Solovev A. E. , Zaitsev V. V. , Zvartau N. E. , Konradi A. O. , Villevalde S. V.
Published: March 2023

The burnout syndrome among healthcare professionals is a headline problem in the world, as it leads to poor health of medical workers, affects patient satisfaction with health care and the healthcare system as a whole. At the same time, existing preventive measures can improve the well-being of staff.

Aim. To study the prevalence of professional burnout syndrome among practicing cardiologists in the Russian Federation (RF).

Material and methods. This cross-sectional study was carried out using the method of online anonymous surveying. The inclusion criterion was the current practical activity in the RF. The study involved 452 cardiologists from 8 federal districts (women; n=377, 83,4%), 48,2% of which worked in a hospital. Occupational burnout was assessed using the Maslach Burnout Inventory (MBI) questionnaire in the Russian language adaptation for healthcare workers by N. E. Vodopyanova and E. S. Starchenkova. The score was calculated on three subscales (emotional exhaustion, depersonalization, personal accomplishment), the maximum score for the subscales was 54, 30 and 48, respectively. The personal accomplishment subscale is the opposite as follows: the higher the score, the less the symptom severity. Additionally, demographic parameters, working conditions, the desire to change job and field of activity were taken into account. Regression analysis was used to establish associations of burnout with factors.

Results. The median score of the emotional exhaustion subscale was 29,5 (23,0; 35,0) points, depersonalization — 12,0 (8,0; 16,0) and personal accomplishment — 32,0 (28,0; 37,0). Men had higher depersonalization score than women as follows: 15,0 (10,0; 18,0) vs 11,0 (8,0; 15,0), p=0,001. High degrees of emotional exhaustion and depersonalization (burnout) were found in 235 (52%) cardiologists, while all three symptoms simultaneously — in 132 (29,2%) doctors. There were no symptoms of burnout in 84 (18,6%) cardiologists. A high degree of burnout was associated with a desire to change job (p<0,001).

Conclusion. A high prevalence of professional burnout among practicing cardiologists in the RF was revealed, which, in turn, is associated with the desire to change job or occupation.
Impact of assessment of fractional flow reserve and instantaneous wave-free ratio on clinical outcomes of percutaneous coronary intervention: a systematic review, meta-analysis and meta-regression analysis
Authors: Golukhova E. Z. , Petrosian K. V. , Abrosimov A. V. , Bulaeva N. I. , Goncharova E. S. , Berdibekov B. Sh.
Published: March 2023

Aim. To conduct a systematic review and meta-analysis to compare clinical outcomes in patients with coronary artery disease (CAD) undergoing percutaneous coronary intervention (PCI) using conventional coronary angiography (CAG) or fractional flow reserve (FFR)-guided PCI. In addition, FFR-guided PCI and PCI guided with instantaneous wave-free ratio (iFR) were compared.

Material and methods. PubMed, Google Scholar databases were searched for studies comparing clinical outcomes in patients with CAD undergoing CAG-guided or FFR/iFR-guided PCI. Dichotomous data analysis was presented as odds ratio (OR) with 95% confidence interval (CI). Adjusted hazard ratio (HR) values from studies with similar evaluation criteria were pooled for meta-analysis.

Results. Six randomized controlled trials (RCTs) from 184 publications were selected for this systematic review and meta-analysis. A total of 2193 patients (mean age, 64,2 years, mean follow-up, 28,0 months) were included. Analysis of RCTs showed that CAG-guided and FFR-guided PCI did not have a significant difference in the incidence of major adverse cardiovascular events (MACE) (OR: 0,78; 95% CI: 0,61-1,00; p=0,05; I2=0%), all-cause death (OR: 0,86; 95% CI: 0,51-1,44; p=0,57; I2=0%) or emergency revascularization (OR: 0,69, 95% CI: 0,46-1,04, p=0,08, I2=0%). However, FFR-guided PCI was associated with a reduced risk of subsequent MI compared with CAG-guided PCI (OR: 0,70; 95% CI: 0,50-0,99; p=0,04; I2=0%). In addition to the results of previous RCTs, we conducted a metaanalysis of 3 observational studies. In total, the CAG-guided and FFR-guided PCI groups included 165012 and 11450 patients, respectively. A meta-analysis showed that FFR-guided PCI was associated with a reduced risk of all-cause mortality (HR: 0,74; 95% CI: 0,63-0,87; P=0,0003) and MI (HR: 0,75; 95% CI: 0,61-0,94; p=0,01). In addition, there was no significant difference between iFRand FFR-guided PCI in terms of MACE (OR: 0,97; 95% CI: 0,76-1,23; p=0,81), all-cause mortality (OR: 0,66; 95% CI: 0,40-1,10; p=0,11), MI (OR: 0,83; 95% CI: 0,56-1,24; p=0,37) or emergency repeated revascularization (OR: 1,16; 95% CI: 0,85-1,58; p=0,34).

Conclusion. FFR-guided PCI is associated with a reduced risk of all-cause mortality and subsequent MI compared with CAG-guided PCI. At the same time, the iFR-guided PCI is not inferior to the FFR-guided method in terms of MACE rate.
Clinical characteristics and frequency of anticoagulation in patients with atrial fibrillation and heart failure: results of a retrospective big data analysis
Authors: Druzhilov M. A. , Kuznetsova T. Yu. , Gavrilov D. V. , Andreichenko A. E. , Novitsky R. E.
Published: March 2023

Aim. To evaluate the clinical characteristics and frequency of prescribed anticoagulant therapy for patients with atrial fibrillation (AF) and heart failure (HF) in subjects of the Russian Federation based on a retrospective big data analysis using artificial intelligence technologies.

Material and methods. For retrospective analysis, information was obtained from the Webiomed predictive analytics platform, which includes depersonalized data from electronic health records of outand/ or inpatients in 6 subjects of the Russian Federation, extracted using artificial intelligence technologies. From the database of patients with AF (n=144431), a group of individuals (n=20970) with an established diagnosis of HF and information on left ventricular ejection fraction (LVEF) was selected.

Results. Patients with AF and HF (men, 43,7%; age 72,1±13,2 years; LVEF, 58,9±11,0%) had a history of smoking in 36,6% of cases, hypertension — in 86,7%, type 2 diabetes — in 26,6%, gout — in 2,7%, stage III and IV-V chronic kidney disease — in 50,9 and 15,6%, lower limb peripheral arterial disease — in 15,8%. The incidence of ischemic stroke, LV myocardial infarction and pulmonary embolism was 8,8, 14,7 and 2,4%, respectively. Anticoagulants, including direct oral ones, were administered to patients with AF and HF in 62,5% and 32,0% of cases, respectively. The frequency of their appointment did not significantly differ depending on LVEF.

Conclusion. Patients with AF and HF are characterized by significant comorbidity, a higher incidence of cardiovascular events compared with the group of individuals with AF without HF, and an unsatisfactory percentage of anticoagulant therapy.
ABORDAGEM STEAM E ENSINO MÉDIO: NOVA LINGUAGEM PARA A EDUCAÇÃO DA JUVENTUDE?
Authors: Maciano Giseli Duardo , Lima Waleska Gonçalves de , Maciel Cristiano , Casagrande Ana Lara
Published: March 2023

Ao indagar sobre uma nova linguagem para a educação da juventude, na era digital, somos compelidos a pensar práticas pedagógicas desenhadas para atender esse público que navega no ciberespaço. Nesse sentido, este estudo se propõe a apresentar a abordagem STEAM (sigla para Science, Technology, Engineering, Art and Mathematics) por diferentes autores e contextos, considerando a atual reforma do ensino médio, com recorte para o estado de Mato Grosso. O objetivo é analisar a evolução da abordagem STEAM e sua articulação com tal reforma, a partir do problema: Qual a contribuição que a abordagem STEAM pode promover no processo de ensino e aprendizagem de estudantes da educação básica, em especial do Ensino Médio? Essa questão motivou a pesquisa de cunho exploratório com delineamento bibliográfico e documental, que, a partir das categorias Protagonismo e Projeto de Vida, operacionalizou a análise de conteúdo no Documento de Referência Curricular de Mato Grosso - etapa Ensino Médio (DRC/MT-EM). A contribuição desta pesquisa está no diálogo entre o STEAM e a nova estrutura para o Ensino Médio, mostrando possíveis caminhos nessa trajetória, destacando a elaboração de políticas que contemplem uma nova linguagem para a educação da juventude, no sentido de possibilitar novos olhares acerca da ressignificação das práticas pedagógicas dentro do espaço escolar por meio da abordagem STEAM.
Criminology of war in the current realities and the need for its development in Ukraine
Authors: Sokurenko Vitalii
Published: March 2023

Many Ukrainian citizens have moved to safer regions of our country or gone abroad. This has led to rethinking of human values, crystallization of attitudes towards death, in particular, whether we are ready to “lay down our lives for our friends” (John 15:13), and thus to exercise the highest expression of love for our neighbour. Our grandfathers and great-grandfathers, who survived famine and other shocks, were most afraid of war. The main wish after 1945 was a peaceful sky on the Earth. What spiritual power and strength was laid in the words of peace? However, seventy years of freedom gradually contributed to the loss of this feeling. The human heart has become petrified, and people have become cruel and hateful to each other, when for certain reasons global circumstances condone war. No one could have thought that our northern neighbor would destroy cities and villages, critical infrastructure of our country, with such force and pace. History and time will give answers to all the questions and condemn the criminals.
Earnings Business Cycles: The Covid Recession, Recovery, and Policy Response
Authors: Larrimore Jeff , Mortenson Jacob , Splinter David
Published: March 2023

Using a panel of tax data, we follow the earnings of individuals over business cycles. Compared to prior recessions, the Covid policy response and recovery were far more progressive. Among workers starting in the bottom quintile, median real earnings including fiscal relief increased 66 percent in 2020 and earnings increases offset relief decreases in the 2021 recovery. After the prior two recessions, this measure had decreased by 24 percent. Among those starting in the top quintile, median and average real earnings were approximately unchanged. This difference from prior recessions is largely attributable to larger Covid-era stimulus payments and unemployment insurance.
Beyond 'Horizontal' and 'Vertical': The Welfare Effects of Complex Integration
Authors: Loudermilk Margaret , Sheu Gloria , Taragin Charles
Published: March 2023

We study the welfare impacts of mergers in markets where some firms are already vertically integrated. Our model features logit Bertrand competition downstream and Nash Bargaining upstream. We numerically simulate four merger types: vertical mergers between an unintegrated retailer and an unintegrated wholesaler, downstream "horizontal" mergers between an unintegrated retailer and an integrated retailer/wholesaler, upstream "horizontal" mergers between an unintegrated wholesaler and an integrated retailer/wholesaler, and integrated mergers between two integrated retailer/wholesaler pairs. We find that mergers that have both horizontal and vertical characteristics typically harm consumers. We apply the model to the Republic/Santek merger as a real-world example.
Occurrence of the Red-bellied Snake (Storeria occipitomaculata) on the margins of a disjunct range
Authors: Schaaf Matthew , Caven Andrew
Published: March 2023

The Red-bellied Snake (Storeria occipitomaculata) can be found throughout much of eastern North America, though two notable disjunct populations exist in the Black Hills of southwestern South Dakota and the Central Platte River Valley in southcentral Nebraska, west of the species’ core range. While literature continues to be added on the Red-bellied Snake and its natural history, it remains largely understudied in Nebraska. Throughout much of this species’ range, it is considered associated with woodland and wetland habitat features. On 28 September 2021, we detected one Red-bellied Snake near a treeless playa wetland in the Rainwater Basins ecoregion of southcentral Nebraska. Using a Grubbs Test to determine significant outliers, we found that this record was further from the Platte River than other previous accounts of this species in the state. This observation suggests this species may be found in other portions of the Rainwater Basins and considerably further from the Platte River than previously believed. Our observation along with other recent work indicates that Red-bellied Snakes may persist in herbaceous habitats lacking established woodland that include sufficient wetland features to support their primary food sources, including gastropods and other soft-bodied invertebrates. Due to the fragmentation of suitable habitats in the Rainwater Basins, coupled with the low dispersal of Red-bellied Snakes, populations persisting in the region are likely to be isolated.
REFERENDUM AS A WAY TO RESOLVE TERRITORIAL DISPUTES: PRO ET CONTRA
Authors:   Taras Shevchenko National University of Kyiv, Ukraine, Tsvietkova Yulianna
Published: March 2023

The article focuses on the analysis of the application of the direct forms of democracy for the purpose of the resolution of the territorial disputes between the states and the way to determine the fate of the territory in question. The purpose of the article is to analyze theoretical and practical peculiarities of applying a referendum as a mean of resolution of the territorial disputes based on the state and legal experience, western legal tradition doctrine and comparison of its advantages and disadvantages. The research methodology is based on the combination of the analysis and synthesis methods, logical, formal legal, teleological and anthropological methods. Application of these methods allows evaluating the principal features of a referendum, and advantages and disadvantages of its application towards the resolution of the territorial disputes. The conclusion of the article is that the analysis of the principal features of a referendum and plebiscite as the forms of direct democracy in the context of their application towards the resolution of the territorial disputes has demonstrated that despite of all of the positive features of these legal institutes as a way of democratic expression of the people's will, the disadvantages of its application prevail. The most serious and principal drawbacks which distort the concept of applying referendum for determining the fate of a disputed territory are: inability to determine the range of persons who are allowed to take part in a referendum, different legal bases of the disputing states, high probability of manipulation, bias and even overt fraud during organization and holding a referendum, violations of the basic principles of the electoral law, absence of an obligation to respect the result of such a referendum for a disputing state, especially in case the referendum was held by the other side of the dispute or by a third party. The above mentioned factors lead to the situation when the legal positions of the disputing parties are undetermined, ambiguous, controversial and disputable and thus can be ignored or challenged by the other party; as a result, the territorial dispute remains unresolved.
THEORIES OF THE ORIGIN OF THE STATE: DOCTRINE LEVEL OF KNOWLEDGE
Authors:   Taras Shevchenko National University of Kyiv, Ukraine, Ponomarenko Nataliia
Published: March 2023

An important aspect of knowing the state is finding out the laws of its formation. The substantiation of such regularities requires the analysis of ideas, concepts and theories existing in general theoretical science, devoted to the problems of researching the factors and causes of formation. The article clarifies the relevance of the selected problem, its theoretical and practical significance. Attention is focused on the lack of unity among scientists in their views on the process of the origin of the state. The main reasons for the variety of existing theories are determined. On the basis of elucidating the etymological meaning of the categories "theory" and "doctrine", the author's vision of the category "theory of the origin of the state" is substantiated and their features are distinguished. Special attention is paid to the classification of theories of the origin of the state and their characteristics from the point of view of the purpose, content and significance of the laws of state formation. The purpose of the publication is to clarify the doctrinal aspects of the process of the emergence and formation of the state as a special means of organizing society and to give it features of systematicity. The objectivity of the obtained research results was ensured by the application of a system of scientific approaches, principles and methods of cognition. In the process of achieving the set goal, synergistic, systemic, axiological, phenomenological approaches were used, which formed the worldview basis of the study of theories of the origin of the state. The principles of comprehensiveness, historicism, comprehensiveness, professionalism, and systematicity were of great importance in the research process. It should also be mentioned such philosophical-light ice methods as the materialistic one, which emphasizes the knowledge of statehood depending on the economic conditions of social reality and their objectivity; dialectical that studies the formation of the state as a natural result of the development of society, and idealistic one connecting the formation of the state with the subjective consciousness of scientists-authors of theories of the origin of the state. As a result, a conclusion was made about the importance of the doctrinal analysis of the process of state formation and its significance for substantiating the laws of state formation.
PROBLEMS OF DEVELOPMENT OF DOCTRINE OF RULE OF LAW IN DECISIONS OF THE CONSTITUTIONAL COURT OF UKRAINE DURING 1997–2016
Authors:   Taras Shevchenko National University of Kyiv, Ukraine, Malyshev Borys
Published: March 2023

The purpose of the article is a critical analysis of legal positions in practice of the first 20 years of work of the Constitutional Court of Ukraine (hereinafter referred to as the CCU), which deals with the attempts of this body to give a vision of the content and structure of the rule of law. The methodology of the article is a systematic approach, a method of comparison, a formal-logical method. As a result, the doctrine is characterized by unclear, lack of a unified approach and criteria for inclusion of certain phenomena in the list of components of the rule of law. Most of the above decisions of the CCU deal with such a component of the rule of law as justice and, in particular, its form in the form of proportionality. The most detailed element of the rule of law in the decisions of the CCU is the requirement of legal certainty, including the principle of prohibition of retroactive operation of the law in time and respect for res judicata. The next element of the rule of law is the right of a person to a fair trial, in particular, the requirement of the compulsory presence of judicial control over the limitation of human rights. In the decisions of the CCU there is a mechanical approach, under which all new elements are regularly added to the content of the rule of law, without explaining the criteria of such addition and without determining the place and role of the new element among those already available. If in CCU's decisions continue to dominate the "inclusive," and "flexible," idea of the rule of law, it will only lead to the fact that the practical meaning of article 8, part 1, of the Constitution will gradually disappear, and this category will finally "dissolve" and de facto become superfluous.