bluuebunny/crossref_metadata_2025 huggingface dataset:
Shake Table Test for the Collapse Investigation of a Typical Multi-Story Reinforced Concrete Frame Structure in the Meizoseismal Area
Authors: Xu Weixiao , Yang Weisong , Zhang Chunwei , Yu Dehu
Published: June 2017

According to statistics from past earthquakes, it is observed that multi-story reinforced concrete (RC) frames represent a large proportion of the structural failures or collapses in seismic events. Hence, research on seismic collapse mechanisms and risks of RC frame structures subjected to extreme earthquakes is of foremost importance. Both experimental and numerical studies have been substantially carried out in this field. In order to represent an actual process of structural damage in an actual seismic event and provide a calibration test for numerical studies, a shake table collapse test of a typical multi-story RC frame structural model, which is scaled from a nearly collapsed building in the 2010 Ms 7.1 Yushu earthquake in China, was performed. Both the test and earthquake field investigation indicate that severe damage mainly occurred at the column ends. As dual structural systems, i.e., systems combining frames and additional members that mainly carry seismic loading, could be a better way to solve the unexpected damage mechanism of RC frames, a practical stiffness iteration design method based on the nonlinear static analysis to obtain the optimal stiffness demanding of the lateral load-resisting members in each story is proposed. This approach aims to control the structural deformation pattern along the height. The outcome of this study provides some intrinsic understanding of the inherent collapse mechanisms of similar RC frames during strong earthquakes. It also offers a practical design method to improve the seismic collapse resistance of RC frames.
Mass Timber Rocking Panel Retrofit of a Four-Story Soft-Story Building with Full-Scale Shake Table Validation
Authors: Bahmani Pouria , Van de Lindt John , Iqbal Asif , Rammer Douglas
Published: June 2017

Soft-story wood-frame buildings have been recognized as a disaster preparedness problem for decades. There are tens of thousands of these multi-family three- and four-story structures throughout California and other cities in the United States. The majority were constructed between 1920 and 1970, with many being prevalent in the San Francisco Bay Area in California. The NEES-Soft project was a five-university multi-industry effort that culminated in a series of full-scale soft-story wood-frame building tests to validate retrofit philosophies proposed by (1) the Federal Emergency Management Agency (FEMA) P-807 guidelines and (2) a performance-based seismic retrofit (PBSR) approach developed within the project. Four different retrofit designs were developed and validated at full-scale, each with specified performance objectives, which were typically not the same. This paper focuses on the retrofit design using cross laminated timber (CLT) rocking panels and presents the experimental results of the full-scale shake table test of a four-story 370 m2 (4000 ft2) soft-story test building with that FEMA P-807 focused retrofit in place. The building was subjected to the 1989 Loma Prieta and 1992 Cape Mendocino ground motions scaled to 5% damped spectral accelerations ranging from 0.2 to 0.9 g.
Hydrogen Storage Technologies for Smart Grid Applications
Authors: Lazarou Stavros , Makridis Sofoklis
Published: June 2017

The electricity sector is among the main contributors to carbon emissions. This sector has the potential to reduce its carbon emissions through producing electric energy from zero-emitting facilities and optimizing consumption to better accommodate low-carbon emissions. The use of hydrogen combined with smart grids, as analyzed in this manuscript, can substantially contribute to climate change mitigation.
Engaging Elementary Students in the Creative Process of Mathematizing Their World through Mathematical Modeling
Authors: Suh Jennifer , Matson Kathleen , Seshaiyer Padmanabhan
Published: June 2017

This paper examines the experiences of two elementary teachers’ implementation of mathematical modeling in their classrooms and how the enactment by the teachers and the engagement by students exhibited their creativity, critical thinking, collaboration and communication skills. In particular, we explore the questions: (1) How can phases of mathematical modeling as a process serve as a venue for exhibiting students’ critical 21st century skills? (2) What were some effective pedagogical practices teachers used as they implemented mathematical modeling with elementary students and how did these promote students’ 21st century skills? We propose that mathematical modeling provides space for teachers and students to have a collective experience through the iterative process of making sense of and building knowledge of important mathematical ideas while engaging in the critical 21st century skills necessary in our complex modern world.
Cyclodextrin-Based Nanohydrogels Containing Polyamidoamine Units: A New Dexamethasone Delivery System for Inflammatory Diseases
Authors: Argenziano Monica , Dianzani Chiara , Ferrara Benedetta , Swaminathan Shankar , Manfredi Amedea , Ranucci Elisabetta , Cavalli Roberta , Ferruti Paolo
Published: June 2017

Glucocorticoids are widely prescribed in treatment of rheumatoid arthritis, asthma, systemic lupus erythematosus, lymphoid neoplasia, skin and eye inflammations. However, well-documented adverse effects offset their therapeutic advantages. In this work, novel nano-hydrogels for the sustained delivery of dexamethasone were designed to increase both bioavailability and duration of the administered drug and reducing the therapeutic dose. Hydrogels are soft materials consisting of water-swollen cross-linked polymers to which the insertion of cyclodextrin (CD) moieties adds hydrophobic drug-complexing sites. Polyamidoamines (PAAs) are biocompatible and biodegradable polymers apt to create CD moieties in hydrogels. In this work, β or γ-CD/PAA nanogels have been developed. In vitro studies showed that a pretreatment for 24–48 h with dexamethasone-loaded, β-CD/PAA nanogel (nanodexa) inhibits adhesion of Jurkat cells to human umbilical vein endothelial cells (HUVEC) in conditions mimicking inflammation. This inhibitory effect was faster and higher than that displayed by free dexamethasone. Moreover, nanodexa inhibited COX-2 expression induced by PMA+A23187 in Jurkat cells after 24–48 h incubation in the 10−8–10−5 M concentration range, while dexamethasone was effective only at 10−5 M after 48 h treatment. Hence, the novel nanogel-dexamethasone formulation combines faster action with lower doses, suggesting the potential for being more manageable than the free drug, reducing its adverse side effects.
Precipitation of Carbonate Minerals Induced by the Halophilic Chromohalobacter Israelensis under High Salt Concentrations: Implications for Natural Environments
Authors: Han Zuozhen , Li Dan , Zhao Hui , Yan Huaxiao , Li Peiyuan
Published: June 2017

The precipitation of carbonate minerals induced by halophilic bacteria has aroused wide concern. The study aimed to investigate the characterization and process of biomineralization in high salt systems by halophilic Chromohalobacter israelensis LD532 (GenBank: KX766026) bacteria, isolated from the Yinjiashan Saltern in China. Carbonate minerals were induced in magnesium sulfate and magnesium chloride medium, respectively. The mineral phase, morphology, and elemental composition of minerals were analyzed using X-ray p owder diffraction, scanning electron microscopy, and energy dispersive X-ray detection. Cells and ultrathin slices were studied using high resolution transmission electron microscopy, selected area electron diffraction, and energy dispersive X-ray detection. The carbonic anhydrase and ammonia released from LD532 bacteria increased pH of the medium and promoted the carbonate precipitation. Magnesium calcite and aragonite were induced by LD532 bacteria in magnesium chloride medium at an Mg/Ca molar ratio of 2, while Magnesium calcite and monohydrocalcite were precipitated in magnesium sulfate medium at the same Mg/Ca ratio, only monohydrocalcite were formed in both control groups. The morphologies and compositions of minerals in MgSO4 and MgCl2 solutions displayed significant differences, indicating different Mg2+ could affect physiological and biochemical activities of LD532 bacteria and thus affect the mineral deposition. Further study showed the nucleation sites were located on extracellular polymeric substances and intracellular vesicles of LD532 bacteria. This study is beneficial to the mechanism of carbonate biomineralization in natural salt environments.
Green Synthesis of Zinc Oxide Nanoparticles for Enhanced Adsorption of Lead Ions from Aqueous Solutions: Equilibrium, Kinetic and Thermodynamic Studies
Authors: Azizi Susan , Mahdavi Shahri Mahnaz , Mohamad Rosfarizan
Published: June 2017

In the present study, ZnO nanoparticles (NPs) were synthesized in zerumbone solution by a green approach and appraised for their ability to absorb Pb(II) ions from aqueous solution. The formation of as-synthesized NPs was established by X-ray diffraction (XRD), Transmission Electron Microscopy (TEM), and UV–visible studies. The XRD and TEM analyses revealed high purity and wurtzite hexagonal structure of ZnO NPs with a mean size of 10.01 ± 2.6 nm. Batch experiments were performed to investigate the impact of process parameters viz. Pb(II) concentration, pH of solution, adsorbent mass, solution temperature, and contact time variations on the removal efficiency of Pb(II). The adsorption isotherm data provided that the adsorption process was mainly monolayer on ZnO NPs. The adsorption process follows pseudo-second-order reaction kinetic. The maximum removal efficiencies were 93% at pH 5. Thermodynamic parameters such as enthalpy change (ΔH0), free energy change (ΔG0), and entropy change (ΔS0) were calculated; the adsorption process was spontaneous and endothermic. The good efficiency of the as-synthesized NPs makes them attractive for applications in water treatment, for removal of heavy metals from aqueous system.
Systematic Review of Chemical Constituents in the Genus Lycium (Solanaceae)
Authors: Qian Dan , Zhao Yaxing , Yang Guang , Huang Luqi
Published: June 2017

The Lycium genus is widely used as a traditional Chinese medicine and functional food. Many of the chemical constituents of the genus Lycium were reported previously. In this review, in addition to the polysaccharides, we have enumerated 355 chemical constituents and nutrients, including 22 glycerogalactolipids, 29 phenylpropanoids, 10 coumarins, 13 lignans, 32 flavonoids, 37 amides, 72 alkaloids, four anthraquinones, 32 organic acids, 39 terpenoids, 57 sterols, steroids, and their derivatives, five peptides and three other constituents. This comprehensive study could lay the foundation for further research on the Lycium genus.
Modeling HSV-1 Latency in Human Embryonic Stem Cell-Derived Neurons
Authors: Pourchet Aldo , Modrek Aram , Placantonakis Dimitris , Mohr Ian , Wilson Angus
Published: June 2017

Herpes simplex virus 1 (HSV-1) uses latency in peripheral ganglia to persist in its human host, however, recurrent reactivation from this reservoir can cause debilitating and potentially life-threatening disease. Most studies of latency use live-animal infection models, but these are complex, multilayered systems and can be difficult to manipulate. Infection of cultured primary neurons provides a powerful alternative, yielding important insights into host signaling pathways controlling latency. However, small animal models do not recapitulate all aspects of HSV-1 infection in humans and are limited in terms of the available molecular tools. To address this, we have developed a latency model based on human neurons differentiated in culture from an NIH-approved embryonic stem cell line. The resulting neurons are highly permissive for replication of wild-type HSV-1, but establish a non-productive infection state resembling latency when infected at low viral doses in the presence of the antivirals acyclovir and interferon-α. In this state, viral replication and expression of a late viral gene marker are not detected but there is an accumulation of the viral latency-associated transcript (LAT) RNA. After a six-day establishment period, antivirals can be removed and the infected cultures maintained for several weeks. Subsequent treatment with sodium butyrate induces reactivation and production of new infectious virus. Human neurons derived from stem cells provide the appropriate species context to study this exclusively human virus with the potential for more extensive manipulation of the progenitors and access to a wide range of preexisting molecular tools.
DNA Binding with Acetate Bis(1,10-phenanthroline)silver(I) Monohydrate in a Solution and Metallization of Formed Structures
Authors: Kasyanenko Nina , Qiushi Zhang , Bakulev Vladimir , Osolodkov Mikhail , Sokolov Petr , Demidov Viktor
Published: June 2017

The study of DNA interaction with the acetate bis(1,10-phenanthroline)silver(I) monohydrate in a solution is of interest both for understanding the mechanism of biological activity of silver compound and for forming ordered structures (DNA fibrils) that can be used to solve various problems in the field of nanotechnology. The analysis of changing the DNA conformation (secondary structure, persistent length and volume effects) during the interaction by the methods of UV spectroscopy with the analysis of DNA melting, circular dichroism, viscosity, flow birefringence, AFM (atomic force microscopy) and SEM (scanning electron microscopy) was performed. The formation of two types of complexes was observed. At lower concentration of compound in DNA solution, silver atoms form the coordination bonds with a macromolecule, while the released phenanthroline ligands intercalate between DNA bases. When the concentration of the compound increases, the phenanthroline ligands form an ordered “layer” around the helix. The excess of silver compounds in the DNA solution (with more than five silver atoms per base pair), DNA precipitation is observed with the formation of long fibrils. It was shown that the binding of silver to DNA during the formation of complexes provides further metallization of the resulting structures with the aid of reducing agents; phenanthroline ligands influence the result of such metallization.
Slope-Restricted Multi-Scale Feature Matching for Geostationary Satellite Remote Sensing Images
Authors: Zeng Dan , Wu Lidan , Chen Boyang , Shen Wei
Published: June 2017

For geostationary meteorological satellite (GSMS) remote sensing image registration, high computational cost and matching error are the two main challenging problems. To address these issues, this paper proposes a novel algorithm named slope-restricted multi-scale feature matching. In multi-scale feature matching, images are subsampled to different scales. From a small scale to a large scale, the offsets between the matched pairs are used to narrow the searching area of feature matching for the next larger scale. Thus, the feature matching is accomplished from coarse to fine, which will make the matching process more accurate and reduce errors. To enhance the matching performance, the outliers in the matched pairs are rectified by using slope-restricted rectification, which is based on local geometric similarity. Compared with other algorithms, the experimental results show that our proposed method is more accurate and efficient.
Effect of Corporate Governance Structure on the Financial Performance of Johannesburg Stock Exchange (JSE)-Listed Mining Firms
Authors: Dzingai Isaih , Fakoya Michael
Published: June 2017

There have been many corporate collapses and financial crises in recent years linked to a lack of effective corporate governance. The South African King IV Code of Corporate Governance recommends that corporate governing bodies should be comprised of an appropriate balance of knowledge, diversity, and independence for discharging their duties objectively and more efficiently. This study examines the effect of corporate governance structures on firm financial performance. The secondary data of selected Johannesburg Stock Exchange (JSE), Socially Responsible Investment (SRI) Index-listed mining firms’ sustainability reports, and integrated annual financial statements are used. Using panel data analysis of the random effects model, we determined the relationship between board independence and board size and the return on equity (ROE) for the period 2010–2015. Results indicate a weak negative correlation between ROE and board size, and a weak, but positive, correlation between ROE and board independence. Additionally, there is a positive, but weak, correlation between ROE and sales growth, but a negative and weak relationship between ROE and firm size. The study suggests that effective corporate governance through a small effective board and monitoring by an independent board result in increased firm financial performance. We recommend that South African companies see compliance with the recommendations of the King IV Code on Corporate Governance not as a liability, but an ethical investment that may likely yield financial benefit in the long-term. Although complying with corporate governance principles does not necessarily translate into a significant economic benefit, firms should, however, continue to adopt corporate governance for ethical reasons to meet stakeholder’s social and environmental needs for sustainable development.
Coralsnake Venomics: Analyses of Venom Gland Transcriptomes and Proteomes of Six Brazilian Taxa
Authors: Aird Steven , Da Silva Nelson , Qiu Lijun , Villar-Briones Alejandro , Saddi Vera , Pires de Campos Telles Mariana , Grau Miguel , Mikheyev Alexander
Published: June 2017

Venom gland transcriptomes and proteomes of six Micrurus taxa (M. corallinus, M. lemniscatus carvalhoi, M. lemniscatus lemniscatus, M. paraensis, M. spixii spixii, and M. surinamensis) were investigated, providing the most comprehensive, quantitative data on Micrurus venom composition to date, and more than tripling the number of Micrurus venom protein sequences previously available. The six venomes differ dramatically. All are dominated by 2–6 toxin classes that account for 91–99% of the toxin transcripts. The M. s. spixii venome is compositionally the simplest. In it, three-finger toxins (3FTxs) and phospholipases A2 (PLA2s) comprise >99% of the toxin transcripts, which include only four additional toxin families at levels ≥0.1%. Micrurus l. lemniscatus venom is the most complex, with at least 17 toxin families. However, in each venome, multiple structural subclasses of 3FTXs and PLA2s are present. These almost certainly differ in pharmacology as well. All venoms also contain phospholipase B and vascular endothelial growth factors. Minor components (0.1–2.0%) are found in all venoms except that of M. s. spixii. Other toxin families are present in all six venoms at trace levels (<0.005%). Minor and trace venom components differ in each venom. Numerous novel toxin chemistries include 3FTxs with previously unknown 8- and 10-cysteine arrangements, resulting in new 3D structures and target specificities. 9-cysteine toxins raise the possibility of covalent, homodimeric 3FTxs or heterodimeric toxins with unknown pharmacologies. Probable muscarinic sequences may be reptile-specific homologs that promote hypotension via vascular mAChRs. The first complete sequences are presented for 3FTxs putatively responsible for liberating glutamate from rat brain synaptosomes. Micrurus C-type lectin-like proteins may have 6–9 cysteine residues and may be monomers, or homo- or heterodimers of unknown pharmacology. Novel KSPIs, 3× longer than any seen previously, appear to have arisen in three species by gene duplication and fusion. Four species have transcripts homologous to the nociceptive toxin, (MitTx) α-subunit, but all six species had homologs to the β-subunit. The first non-neurotoxic, non-catalytic elapid phospholipase A2s are reported. All are probably myonecrotic. Phylogenetic analysis indicates that the six taxa diverged 15–35 million years ago and that they split from their last common ancestor with Old World elapines nearly 55 million years ago. Given their early diversification, many cryptic micrurine taxa are anticipated.
Improvement to the Huff Curve for Design Storms and Urban Flooding Simulations in Guangzhou, China
Authors: Pan Cuilin , Wang Xianwei , Liu Lin , Huang Huabing , Wang Dashan
Published: June 2017

The storm hyetograph is critical in drainage design since it determines the peak flooding volume in a catchment and the corresponding drainage capacity demand for a return period. This study firstly compares the common design storms such as the Chicago, Huff, and Triangular curves employed to represent the storm hyetographs in the metropolitan area of Guangzhou using minute-interval rainfall data during 2008–2012. These common design storms cannot satisfactorily represent the storm hyetographs in sub-tropic areas of Guangzhou. The normalized time of peak rainfall is at 33 ± 5% for all storms in the Tianhe and Panyu districts, and most storms (84%) are in the 1st and 2nd quartiles. The Huff curves are further improved by separately describing the rising and falling limbs instead of classifying all storms into four quartiles. The optimal time intervals are 1–5 min for deriving a practical urban design storm, especially for short-duration and intense storms in Guangzhou. Compared to the 71 observed storm hyetographs, the Improved Huff curves have smaller RMSE and higher NSE values (6.43, 0.66) than those of the original Huff (6.62, 0.63), Triangular (7.38, 0.55), and Chicago (7.57, 0.54) curves. The mean relative difference of peak flooding volume simulated with SWMM using the Improved Huff curve as the input is only 2%, −6%, and 8% of those simulated by observed rainfall at the three catchments, respectively. In contrast, those simulated by the original Huff (−12%, −43%, −16%), Triangular (−22%, −62%, −38%), and Chicago curves (−17%, −19%, −21%) are much smaller and greatly underestimate the peak flooding volume. The Improved Huff curve has great potential in storm water management such as flooding risk mapping and drainage facility design, after further validation.
Correlation of surface pressure and hue of planarizable push–pull chromophores at the air/water interface
Authors: Neuhaus Frederik , Zobi Fabio , Brezesinski Gerald , Dal Molin Marta , Matile Stefan , Zumbuehl Andreas
Published: June 2017

It is currently not possible to directly measure the lateral pressure of a biomembrane. Mechanoresponsive fluorescent probes are an elegant solution to this problem but it requires first the establishment of a direct correlation between the membrane surface pressure and the induced color change of the probe. Here, we analyze planarizable dithienothiophene push–pull probes in a monolayer at the air/water interface using fluorescence microscopy, grazing-incidence angle X-ray diffraction, and infrared reflection–absorption spectroscopy. An increase of the lateral membrane pressure leads to a well-packed layer of the ‘flipper’ mechanophores and a clear change in hue above 18 mN/m. The fluorescent probes had no influence on the measured isotherm of the natural phospholipid DPPC suggesting that the flippers probe the lateral membrane pressure without physically changing it. This makes the flipper probes a truly useful addition to the membrane probe toolbox.
Quality Of General Life In The Medicine Course Students
Authors: Andrade Karina Oliveira de , Carvalho Alexandra Maria Almeida , Figueiró-Filho Ernesto Antonio , Pontes Elenir Rose Jardim Cury , Nucci Giovana Kátia Viana , Azevedo Isabelle Campos de , Ferreira Júnior Marcos Antonio
Published: June 2017

Objective: To evaluate the general quality of life in medical students.

Method: This is a cross-sectional observational study of 320 students from the Federal University of Mato Grosso do Sul, located in Campo Grande, Brazil, who answered the WHOQOL-BREF quality of life assessment instrument.

Results: The medical students evaluated having a good general quality of life and good satisfaction with their health. According to the domains, the psychological domain was smaller than the social relationships and environment domains. The students had a difference in the values of the WHOQOL-BREF scores only between the psychological and the environment domains and lower values in the men, in the physical and psychological domains. During the years of the course, there was a difference between the domains only for the 3rd grade of the course, with lower scores for the psychological domain. In each domain, the values of the WHOQOL-BREF scores were higher in the second grade compared to the 5th grade in the social relationships domain, and in the environmental domain. The 1st grade had lower values than the 6th grade.

Conclusion: Medical students have a positive characterization of the quality of life, although it is less in the psychological domain, by the frequency of negative feelings not enjoying life or concentrating in a satisfactory way. Female students are more fragile in the psychological and physical domain than male students.

Keywords: Quality of life; Medical students; Medical Education.
SHANGHAI IN THE NEW ECONOMY OF GLOBAL FLOWS SHAPING URBAN FORM AND CONNECTEDNESS IN THE DIGITAL AGE
Authors: Salat Serge
Published: June 2017

This paper is a contribution to the significant research program having developed around the concept of the global city over the last four decades in urban sociology and in political geography. Global cities can be defined both as places and as locations in a network of flows. We use a network and complexity theory perspective to contribute to the debate about global cities and we apply this approach to a rising global city: Shanghai. Cities are networks from which locations emerge, and global cities are the places that emerge as interconnected command centres in the most dynamic and connected nodes in the global network of flows. As places, global cities present a highly unequal landscape of economic growth at intra-urban scale, with peaks of extreme concentration of wealth creation in specific locations within their urban space. To acquire a similar intensity of agglomeration economies in high-end services and in finance as global cities such as London, New York, Tokyo, Seoul, Singapore, and Hong Kong, Shanghai spatial structure needs more concentration and a more complex articulation of its economic densities. Pareto distributions, which are the “signature” of complexity, are the hidden order of the spiky spatial economic landscapes of global cities, for the distribution of people, jobs, and economic densities, office space density, accessibility to jobs, rents, subway network centralities. Within the dynamics of global networks, Shanghai challenge is to become a hub across five flows of goods, services, finance, people, and data and communication, in which Singapore and Hong Kong have acquired dominant positions as waypoints. The transformation of the global landscape of flows with an increasing growth of knowledge-based flows, cross-border flows, and digital flows puts Shanghai business model, dominated today by goods flows, at risk. Shanghai would benefit developing stronger air and Internet connectivity and building collaborative bridges with global cities.
SHANGHAIED INTO THE FUTURE: THE ASIANIZATION OF THE FUTURE METROPOLIS IN POST-BLADE RUNNER CINEMA
Authors: CERESA Marco
Published: June 2017

The cliched 1930–1950 Western cinematic images of Shanghai as a fascinating den of iniquity, and, in contrast, as a beacon of modernity, were merged in Fritz Lang’s Metropolis. As a result, a new standard emerged in science fiction films for the representation of future urban conglomerates: the Asianized metropolis. The standard set by this film, of a dark dystopian city, populated by creatures of all races and genetic codes, will be adopted in most of the representations of future cities in non-Asian cinema. This article traces the representation of Shanghai in Western cinema from its earliest days (1932– Shanghai Express) through Blade Runner (1982) to the present (2013– Her). Shanghai, already in the early 1930s, sported extremely daring examples of modern architecture and, at the same time, in non-Asian cinema, was represented as a city of sin and depravity. This dualistic representation became the standard image of the future Asianized city, where its debauchery was often complemented by modernity; therefore, it is all the more seedy. Moreover, it is Asianized, the “Yellow Peril” incarnated in a new, much more subtle, much more dangerous way. As such, it is deserving of destruction, like Sodom and Gomorrah.
Legacy ExtraGalactic UV Survey with The Hubble Space Telescope: Stellar Cluster Catalogs and First Insights Into Cluster Formation and Evolution in NGC 628∗
Authors: Adamo A. , Ryon J. E. , Messa M. , Kim H. , Grasha K. , Cook D. O. , Calzetti D. , Lee J. C. , Whitmore B. C. , Elmegreen B. G. , Ubeda L. , Smith L. J. , Bright S. N. , Runnholm A. , Andrews J. E. , Fumagalli M. , Gouliermis D. A. , Kahre L. , Nair P. , Thilker D. , Walterbos R. , Wofford A. , Aloisi A. , Ashworth G. , Brown T. M. , Chandar R. , Christian C. , Cignoni M. , Clayton G. C. , Dale D. A. , de Mink S. E. , Dobbs C. , Elmegreen D. M. , Evans A. S. , Gallagher III J. S. , Grebel E. K. , Herrero A. , Hunter D. A. , Johnson K. E. , Kennicutt R. C. , Krumholz M. R. , Lennon D. , Levay K. , Martin C. , Nota A. , Östlin G. , Pellerin A. , Prieto J. , Regan M. W. , Sabbi E. , Sacchi E. , Schaerer D. , Schiminovich D. , Shabani F. , Tosi M. , Van Dyk S. D. , Zackrisson E.
Published: June 2017

We report the large effort that is producing comprehensive high-level young star cluster (YSC) catalogs for a significant fraction of galaxies observed with the Legacy ExtraGalactic UV Survey (LEGUS) Hubble treasury program. We present the methodology developed to extract cluster positions, verify their genuine nature, produce multiband photometry (from NUV to NIR), and derive their physical properties via spectral energy distribution fitting analyses. We use the nearby spiral galaxy NGC 628 as a test case for demonstrating the impact that LEGUS will have on our understanding of the formation and evolution of YSCs and compact stellar associations within their host galaxy. Our analysis of the cluster luminosity function from the UV to the NIR finds a steepening at the bright end and at all wavelengths suggesting a dearth of luminous clusters. The cluster mass function of NGC 628 is consistent with a power-law distribution of slopes

and a truncation of a few times 105

. After their formation, YSCs and compact associations follow different evolutionary paths. YSCs survive for a longer time frame, confirming their being potentially bound systems. Associations disappear on timescales comparable to hierarchically organized star-forming regions, suggesting that they are expanding systems. We find mass-independent cluster disruption in the inner region of NGC 628, while in the outer part of the galaxy there is little or no disruption. We observe faster disruption rates for low mass (≤104

) clusters, suggesting that a mass-dependent component is necessary to fully describe the YSC disruption process in NGC 628.
Feasibility of Using Mixed-Media Vignettes to Enhance Nursing Knowledge and Attitudes About Pain Management
Authors: Keen Alyson , Embree Jennifer , Lancaster Shelley , Bartlett Ellis Rebecca J.
Published: June 2017

Patients admitted to the acute care setting with persistent pain are at risk for inadequate pain control. Nursing education and pain management perceptions affect partnership with the patient to achieve effective pain management. Traditional educational approaches that are of didactic nature do not necessarily promote problem-solving and critical thinking skills. This pilot study used a mixed-media vignette approach to provide real-life pain examples to influence both the knowledge and attitudes of staff nurses through problem-based learning. This article describes and evaluates the feasibility of using mixed-media vignettes to deliver pain education to bedside nurses. Two mixed-media vignettes were delivered through nine in-service sessions provided to day, night, and weekend shifts in rolling 30-minute intervals. A feasibility framework was used to evaluate project implementation. The results from this pilot study suggest that this educational approach has the potential to improve patient satisfaction scores in relation to pain management.

J Contin Educ Nurs.2017;48(6):282–288.
Both RAD5-dependent and independent pathways are involved in DNA damage-associated sister chromatid exchange in budding yeast
Authors: Fasullo Michael T. , Sun Mingzeng
Published: June 2017

Sister chromatids are preferred substrates for recombinational repair after cells are exposed to DNA damage. While some agents directly cause double-strand breaks (DSBs), others form DNA base adducts which stall or impede the DNA replication fork. We asked which types of DNA damage can stimulate SCE in budding yeast mutants defective in template switch mechanisms and whether PCNA polyubiquitination functions are required for DNA damage-associated SCE after exposure to potent recombinagens. We measured spontaneous and DNA damage-associated unequal sister chromatid exchange (uSCE) in yeast strains containing two fragments of his3 after exposure to MMS, 4-NQO, UV, X rays, and HO endonuclease-induced DSBs. We determined whether other genes in the pathway for template switching, including UBC13, MMS2, SGS1, and SRS2 were required for DNA damage-associated SCE. RAD5 was required for DNA damage-associated SCE after exposure to UV, MMS, and 4-NQO, but not for spontaneous, X-ray-associated, or HO endonuclease-induced SCE. While UBC13, MMS2, and SGS1 were required for MMS and 4NQO-associated SCE, they were not required for UV-associated SCE. DNA damage-associated recombination between his3 recombination substrates on non-homologous recombination was enhanced in rad5 mutants. These results demonstrate that DNA damaging agents that cause DSBs stimulate SCE by RAD5-independent mechanisms, while several potent agents that generate bulky DNA adducts stimulate SCE by multiple RAD5-dependent mechanisms. We suggest that DSB-associated recombination that occurs in G2 is RAD5-independent.
Dietary fatty acids and lipoproteins on progression of age-related macular degeneration
Authors: Montserrat-de la Paz S. , Naranjo M. C. , Bermúdez B. , López S. , Abia R. , Muriana F. J.G.
Published: June 2017

Age-related macular degeneration (AMD) is a medical condition of central loss vision and blindness. Numerous studies have revealed that changes on certain dietary fatty acids (FAs) could have useful for AMD management. This review summarizes the effects of dietary omega-3 long-chain PUFAs, MUFAs, and SFAs, and lipoproteins on AMD. Findings are consistent with the beneficial role of dietary omega-3 long-chain PUFAs, while the effects of dietary MUFAs and SFAs appeared to be ambiguous with respect to the possible protection from MUFAs and to the possible adverse impact from SFAs on AMD. Some of the pathological mechanisms associated with lipoproteins on AMD share those observed previously in cardiovascular diseases. It was also noticed that the effects of FAs in the diet and lipoprotein on AMD could be modulated by genetic variants. From a population health perspective, the findings of this review are in favour of omega-3 long-chain FAs recommendations in a preventive and therapeutic regimen to attain lower AMD occurrence and progression rates. Additional long-term and short-term nutrigenomic studies are required to clearly establish the role and the relevance of interaction of dietary FAs, lipoproteins, and genes in the genesis and progression of AMD.
L’éducation et le soin comme agir sur soi : liminaire
Authors: Barbier Jean-Marie
Published: June 2017

Dans un liminaire au numéro, Jean-Marie Barbier s’intéresse à une caractéristique commune à l’éducation et au soin lorsqu’ils sont situés dans une perspective de construction conjointe des activités et des sujets par et dans les activités : ce sont des champs de pratiques qui supposent obligatoirement un « couplage » entre l’activité du professionnel spécialisé et l’activité du public visé par la transformation attendue. C’est le cas plus général de tous les « métiers de la société ». Dans le contexte occidental contemporain, agir sur soi, agir par soi et agir pour soi relèvent aussi souvent d’une même culture d’action. Les actions ordonnées en dominante sur la transformation de soi par soi supposent notamment trois conditions : se reconnaître pour pouvoir agir sur soi ; s’engager comme sujet de sa propre transformation ; un espace de « culture de soi ».
L’analyse des activités du patient : une occasion de réinterroger la notion de travail
Authors: Thievenaz Joris
Published: June 2017

Cet article propose de questionner ce que l’on entend habituellement par « travail » en s’appuyant sur l’analyse des activités conduites par les patients à l’occasion de leur parcours de soin. Les démarches d’analyse du travail en lien avec l’éducation et la formation sont amenées à élargir le champ des activités habituellement étudiées pour accéder à des tâches relevant du domaine quotidien des sujets. Une recherche conduite en immersion au sein d’un service hospitalier nous a permis d’identifier des séquences d’activités qui la plupart du temps demeurent dans l’ « obscurité » de l’agir humain car relevant des « services que l’on se rend à soi-même ». En se référant aux théories et méthodes de la sociologie interactionniste de l’école de Chicago, nous privilégierons ici une analyse reposant sur une étude de cas.
Cours de vie, apprentissage et transformations d’habitudes de vie d’une malade diabétique
Authors: Guerin Jérôme , Zeitler André
Published: June 2017

Cette contribution présente une recherche visant à comprendre les processus et les conditions de changements des habitudes de vie chez une malade diabétique à l’occasion d’une participation longue à un réseau d’Éducation Thérapeutique des Patients (ETP). Les résultats de cette étude montrent que des transformations des habitudes de vie bénéfiques émergent de la fréquentation aux ateliers du réseau. Elles ne sont pas engendrées par une application de procédures, mais au contraire par un long et difficile processus de réappropriation de sensations corporelles significatives, sur le fond essentiel d’une transformation d’interactions sociales associée à une prise de confiance en soi et envers les autres. L’ETP apparaît comme un encouragement décisif à une transformation de la personne et de ses activités, transformation qui reste irréductiblement autonome. L’emploi d’un carnet ethnographique apparaît comme bénéfique dans la transformation des habitudes.
Jeunes diabétiques et projets d’orientation
Authors: Mezza Joëlle , Cohen-Scali Valérie , Lecomte Corinne , Lemasson Nadia , Stoïanoff-Nenoff Chloé
Published: June 2017

Cette recherche exploratoire vise à comprendre les modes de vie d’adolescents diabétiques et les conséquences de la gestion quotidienne du diabète sur la construction des projets d’orientation. Le modèle de la dynamique vocationnelle de Dumora (1990) sert de cadre de référence pour identifier les principaux processus psychosociaux impliqués dans le développement identitaire de l’adolescent-e et le rapport à l’orientation. Nous avons émis deux hypothèses : la première consiste à penser que l’adolescent-e diabétique développe des capacités transférables dans d’autres domaines de vie. Selon la deuxième hypothèse, les adolescents diabétiques intégreraient les contraintes de la maladie pour effectuer des choix d’orientation. A l’appui de l’analyse qualitative de 11 entretiens semi-directifs, il apparaît que nos sujets ne se comportent pas différemment des autres adolescents et n’intègrent pas de manière prioritaire les conséquences de leur maladie dans leur intention d’avenir.
Learning About Genetics in an Elementary Classroom Using a Web-Based Inquiry Science Environment (WISE) Unit
Authors: Ibourk Amal , Williams Michelle , Heidemann Merle
Published: June 2017

Genetics is an increasingly important topic in today's society, yet continues to be an ongoing challenge to the science education community and an important aspect of school student learning. This chapter examines how STEMGenetics, an inquiry-based technology-enhanced online unit, engages upper elementary students in building a better understanding of the concepts of inheritance of traits, variation of traits, and the life cycle of plants. Using pre/post measures, supplemented with qualitative analyses of students' responses, the authors show how upper elementary students' understanding of inheritance and variation of traits, as well as the life cycle of plants, resulted in greater learning gains. In addition, engaging in learning technologies, such as dynamic visualizations, provided the students opportunities to interact with the scientific phenomena and enhanced their reasoning about inheritance of traits and its relationship to the life cycle of plants.
A Case Study of Infusing Collaborative STEM Inquiry Learning With Available Technology Into Undergraduate Student Learning
Authors: MacLeod Katarin Alinta
Published: June 2017

This chapter describes the development, launch, and findings of an undergraduate course entitled “Teaching and Learning in the Physical Sciences”. It was a second-year course that introduced students to content commonly taught within a Bachelor of Education program and connected this content to the literature found in the areas of Physics Educational Research and Chemistry Educational Research. It infused inquiry-based STEM learning allowing students to re-examine content and connect to context, while also examining the pedagogical significance and implications. This chapter provides a qualitatively based insight into students' experiences of the course content and students' voices of the transferability of content from this course to others citing lessons learned, implications for physical science students and recommendations for the future offering.
Technology in Higher Education Administration 25 Years of Leveraging Changes to Content Delivery
Authors: Johnson-Leslie Natalie Ann-Marie , Leslie H. Steve
Published: June 2017

Content delivery in higher education has changed drastically over the past 25 years. The primary focus at the foundation of such change in content delivery results from the ubiquity of technology in all aspects of the society, from business to education. The changes have been made to facilitate student learning, improve user performance, while simultaneously reducing costs. This chapter focuses on the changes made to content delivery, placing emphasis on: relating the features of content delivery showing the most change; demonstrating the impact of technology on content delivery; assessing the role of institutional leaders facilitating change in content delivery; evaluating policies shaping the integration and impact of technology on content delivery; and outlining the issues, trends and controversies impacting content delivery. This chapter will conclude with solutions, recommendations and future research directions.
An Empirical Study to Evaluate the Impact of Demographic Variables to Complaint Behavior of Customers in a Dine-In Restaurant Industry
Authors: Tan Tiffany Adelaine Gan
Published: June 2017

This paper examined the relationship between demographic variables and frequency of dining out to customers' complaint behavior and assessed the relationship between complaint behavior and behavioral intentions. Respondents were 428 graduate students from a major Metropolitan city in the Philippines. The Test for Independence (?2) was used to verify any statistical relationship between the variables. Out of the six proposed hypotheses, only one found strong data support. The results suggested that the propensity to complain differed significantly only across the dining frequency while gender, age, and income accounted for no significant difference. Results also suggested that a positive but weak relationship exists between the customer's behavioral intentions and the complaint behavior of the sample group. However, the intentions after the service failure incident did not differ significantly even after a complaint was filed. The results imply there are other factors that are likely to influence customers' decision to complain.
The Twofold Complexity of Economy Under the Domination of Network Processes and its Manifestation in the Theoretical Landscape and Reality
Authors: Baryshev Alexey A.
Published: June 2017

Complex networks methodology has permeated the spheres of knowledge that deal with heterogeneous networks, introduced by Actor-Network Theory. In the context, cognition of macro socio-economic processes that have determinants, different in ontological sense, does not seem to be so efficient. The author addresses the twofold complexity of these phenomena. The author identifies different types of macro socio-economic complexity as various combinations of ontological and intrinsic network heterogeneities. Extant networks theories are classified in accordance with a particular type of complexity, with which they deal, and thereby the real background of these theories is revealed. The concept of twofold complexity and its types is applied to the economic category of value. The near-term prospects for the creation of Networks Economics are hypothesized. Networks Economics is viewed on as a theory of preferential attachment value interacting with the non-network mode of value.
Consumer Sentiment in Tweets and Coupon Information-Sharing Behavior
Authors: Wang Chen-Ya , Lin Yi-Chun , Chang Hsia-Ching , Chou Seng-cho T.
Published: June 2017

The authors aim to explore the correlation between coupon information-sharing behavior and consumer sentiment by analyzing tweets. They used Twitter application programming interface to retrieve users' tweets, and took a machine learning approach for sentiment analysis. After the data pre-processing procedure, the authors then examined the correlation between sentiments in tweets and coupon information sharing. More than half of the most active users showed that their coupon information-sharing behavior correlated to both positive and negative sentiments. The results also showed that the response, coupon information sharing, for positive/negative sentiment had no significant time shifting pattern for most of the users. This study preliminary verifies the assumption that there is a correlation between users' sentiments in tweets and coupon information-sharing behavior, and indicates some interesting findings. The authors' findings may shed light on whether sentiment plays a role in social media communication concerning the sharing of coupon information.
Long-Term and Short-Term Traffic Forecasting Using Holt-Winters Method
Authors: Raikwar Aditya R. , Sadawarte Rahul R. , More Rishikesh G. , Gunjal Rutuja S. , Mahalle Parikshit N. , Railkar Poonam N.
Published: June 2017

The need of faster life has caused the exponential growth in No. of vehicles on streets. The adverse effects include frequent traffic congestion, less time efficiency, unnecessary fuel consumption, pollution, accidents, etc. One of most important solution for resolving these problems is efficient transportation management system. Data science introduces different techniques and tools for overcoming these problems and to improve the data quality and forecasting inferences. The proposed long-term forecasting model can predict numerical values of effective attributes for a particular day on half-hourly basis, at least 24 hours prior to the time of prediction. The proposed forecasting model for short-term analysis will be having access to data as close as 30-minute difference from the time of prediction. Our proposed solution has integrated use of Holt-Winters (HW) method along with comparability schemes for seasonal approach.