bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Methods and Supplemental Tables 1 and 2 from Collaborative Cancer Epidemiology in the 21st Century: The Model of Cancer Consortia
Authors: Burgio Michael R. , Ioannidis John P.A. , Kaminski Brett M. , DeRycke Eric , Rogers Scott , Khoury Muin J. , Seminara Daniela
Published: April 2023

PDF - 121KB, Exclusion Criteria for Scoring by Scientific Area and Translational Stage, Comparison of Translational Stage of CEC versus non-CEC associated cancer genetics papers, Acknowledgement of CEC contributions in associated papers. Table 1: Scientific areas, their definitions, and examples from the literature analysis. Table 2: Acknowledgment CEC contributions in 472 papers, associated with 4 established CEC, by acknowledgement type.
Supplementary Tables S1-S8 from Pathway Analysis of Genome-wide Association Study in Childhood Leukemia among Hispanics
Authors: Hsu Ling-I , Briggs Farren , Shao Xiaorong , Metayer Catherine , Wiemels Joseph L. , Chokkalingam Anand P. , Barcellos Lisa F.
Published: April 2023

Supplementary Table S1. Assessment of numbers of genes meeting various significance thresholds from GWAS in Hispanic Children in the CCLS. Supplementary Table S2. Overrepresented KEGG pathways among the top results of GWAS in Hispanic children diagnosed with B-ALL. Supplementary Table S3. Overrepresented KEGG pathways among the top results of GWAS in Hispanic children diagnosed with hyperdiploid B-ALL. Supplementary Table S4. Overrepresented KEGG pathways among the top results of GWAS in Hispanic children diagnosed with TEL-AML1 ALL. Supplementary Table S5. Complete list of TMLE P-values for each important gene that are selected for each biological pathway. Supplementary Table S6. Overrepresented GO categories among the top results of the GWAS in Hispanic children diagnosed with ALL. Supplementary Table S7. Overrepresented BioCarta pathways among the top results of the GWAS in Hispanic children diagnosed with ALL. Supplementary Table S8. Overrepresented KEGG pathways among the top results of the GWAS in Hispanic children diagnosed with ALL using Webgestalt and DAVID software
Supplementary Figure 7 from Collaborative Cancer Epidemiology in the 21st Century: The Model of Cancer Consortia
Authors: Burgio Michael R. , Ioannidis John P.A. , Kaminski Brett M. , DeRycke Eric , Rogers Scott , Khoury Muin J. , Seminara Daniela
Published: April 2023

PDF - 45KB, Number of CEC papers in sub-areas of genomics by year.
Supplementary Table 2 from Modeling of the Growth Kinetics of Occult Breast Tumors: Role in Interpretation of Studies of Prevention and Menopausal Hormone Therapy
Authors: Santen Richard J. , Yue Wei , Heitjan Daniel F.
Published: April 2023

PDF file, 41KB, Table with review of effective doubling times of rumors.
Supplementary Figure 2 from Collaborative Cancer Epidemiology in the 21st Century: The Model of Cancer Consortia
Authors: Burgio Michael R. , Ioannidis John P.A. , Kaminski Brett M. , DeRycke Eric , Rogers Scott , Khoury Muin J. , Seminara Daniela
Published: April 2023

PDF - 140KB, Total number and total direct cost of CEC grants by year.
supplementary tables 1-3 from Adult Body Size and Physical Activity in Relation to Risk of Breast Cancer According to Tumor Androgen Receptor Status
Authors: Zhang Xuehong , Eliassen A. Heather , Tamimi Rulla M. , Hazra Aditi , Beck Andrew H. , Brown Myles , Collins Laura C. , Rosner Bernard , Hankinson Susan E.
Published: April 2023

supplementary tables 1-3. Supplementary Table 1. Summary of the study population in the current analysis. Supplementary Table 2.The correlation between AR and ER/PR status for BMI analysis. Supplementary Table 3. Multivariable* Relative Risks of Postmenopausal Breast Cancer by AR Status According to Waist Circumference and waist: hip ratio in the Nurses' Health Study (1986-2006).
Supplementary Figure 1 from Breast Cancer Risk Associated with Estrogen Exposure and Truncating Mutation Location in BRCA1/2 Carriers
Authors: Lecarpentier Julie , Noguès Catherine , Mouret-Fourme Emmanuelle , Buecher Bruno , Gauthier-Villars Marion , Stoppa-Lyonnet Dominique , Bonadona Valérie , Fricker Jean-Pierre , Berthet Pascaline , Caron Olivier , Coupier Isabelle , Pujol Pascal , Faivre Laurence , Gesta Paul , Eisinger François , Mari Véronique , Gladieff Laurence , Lortholary Alain , Luporsi Elisabeth , Leroux Dominique , Venat-Bouvet Laurence , Maugard Christine M. , Colas Chrystelle , Tinat Julie , Lasset Christine , Andrieu Nadine
Published: April 2023

Supplementary Figure 1: Representation of BRCA1 and BRCA2 major functional and risk domains (location of codons)
Supplemental Tables 1-5 and Supplemental Figure Legends from Medical Care Cost of Oropharyngeal Cancer among Texas Patients
Authors: Lairson David R. , Wu Chi-Fang , Chan Wenyaw , Dahlstrom Kristina R. , Tam Samantha , Sturgis Erich M.
Published: April 2023

Supplemental Figure Legends; Supplemental Table 1. Three-digit zip codes for Texas regions; Supplemental Table 2. Procedure codes for identifying OPC treatment modalities; Supplemental Table 3. Summary of the time (days) to initiation of the first modality of therapy during the 2-year follow-up; Supplemental Table 4. Generalized linear model with log link function for the mean monthly cost for the first 2 years after the index date between cases and controls; Supplemental Table 5. Unadjusted and adjusted cost during the first 1 year after the index date for OPC patients and matched controls
Supplemental Figure 2 from Medical Care Cost of Oropharyngeal Cancer among Texas Patients
Authors: Lairson David R. , Wu Chi-Fang , Chan Wenyaw , Dahlstrom Kristina R. , Tam Samantha , Sturgis Erich M.
Published: April 2023

Propensity score distribution between case and control group
Supplementary Information from Genetic Variation Associated with Longer Telomere Length Increases Risk of Chronic Lymphocytic Leukemia
Authors: Ojha Juhi , Codd Veryan , Nelson Christopher P. , Samani Nilesh J. , Smirnov Ivan V. , Madsen Nils R. , Hansen Helen M. , de Smith Adam J. , Bracci Paige M. , Wiencke John K. , Wrensch Margaret R. , Wiemels Joseph L. , Walsh Kyle M.
Published: April 2023

Supplementary Note: ENGAGE Consortium Telomere Group members and affiliations. Supplementary Figure 1: Comparison of allele frequencies in flow-sorted CLL tumor DNA and matched normal DNA among the DFCI subjects. Supplementary Figure 2: Genotypically-estimated leukocyte telomere length (LTL) is not associated with subject age or sex. Supplementary Figure 3: Boxplot comparing genotypically-estimated leukocyte telomere length (LTL) in 273 CLL patients and 5725 controls, after excluding contributions from known CLL risk genes (TERC, TERT. Supplementary Table 1: Subject characteristics of CLL patients and controls
Supplementary Tables 1-2; Supplementary Figures 1-3 from Replication and Heritability of Prostate Cancer Risk Variants: Impact of Population-Specific Factors
Authors: Virlogeux Victor , Graff Rebecca E. , Hoffmann Thomas J. , Witte John S.
Published: April 2023

Supplementary Tables 1-2; Supplementary Figures 1-3. Supplementary Table 1 describes the set of 104 SNPs across the different populations with information about risk allele frequency and strength of association with PrCa. Supplementary Table 2 summarizes the mean linkage disequilibrium calculated with all the pairs of SNPs (index SNPs/all other SNPs) in a window of 500 kb across the different populations for the 104 SNPs. Supplementary Figure 1 compares the log odd ratio between the European population (reference population) and the other populations at each single genetic variant. Supplementary Figure 2 compares the mean recombination rate between the European population (reference population) and the other populations at each single genetic variant. Supplementary Figure 3 compares the cumulative total heritability of liability attributable to each single genetic variant between the European population (reference population) and the other populations.
Supplementary Figure S1 from Coffee Consumption and the Risk of Colorectal Cancer
Authors: Schmit Stephanie L. , Rennert Hedy S. , Rennert Gad , Gruber Stephen B.
Published: April 2023

Supplementary Figure 1. Consumption patterns of different coffee types in A) the total MECC sample, B) Ashkenazi Jews, C) Sephardi Jews, and D) Arabs.
Supplementary Table 3 from Using Genetic Proxies for Lifecourse Sun Exposure to Assess the Causal Relationship of Sun Exposure with Circulating Vitamin D and Prostate Cancer Risk
Authors: Bonilla Carolina , Gilbert Rebecca , Kemp John P. , Timpson Nicholas J. , Evans David M. , Donovan Jenny L. , Hamdy Freddie C. , Neal David E. , Fraser William D. , Davey Smith George , Lewis Sarah J. , Lathrop Mark , Martin Richard M.
Published: April 2023

PDF file - 37K, Association between genetic scores in tertiles and prostate cancer status, adjusted for age at recruitment and population stratification.
Supplemental Table 4 from Prevalence of Major Risk Factors and Use of Screening Tests for Cancer in the United States
Authors: Fedewa Stacey A. , Sauer Ann Goding , Siegel Rebecca L. , Jemal Ahmedin
Published: April 2023

Supplemental Table 4. Prevalence (%) of using an indoor tanning devicea, adults 18 years and older and high school students, National Health Interview Survey and Youth Risk Behavior Survey, 2013.
Supplementary Table 1 from Using Genetic Proxies for Lifecourse Sun Exposure to Assess the Causal Relationship of Sun Exposure with Circulating Vitamin D and Prostate Cancer Risk
Authors: Bonilla Carolina , Gilbert Rebecca , Kemp John P. , Timpson Nicholas J. , Evans David M. , Donovan Jenny L. , Hamdy Freddie C. , Neal David E. , Fraser William D. , Davey Smith George , Lewis Sarah J. , Lathrop Mark , Martin Richard M.
Published: April 2023

PDF file - 40K, Association between pigmentation genetic scores and the first 10 principal components that reflect population stratification.
Supplemental Table 1 from Prevalence of Major Risk Factors and Use of Screening Tests for Cancer in the United States
Authors: Fedewa Stacey A. , Sauer Ann Goding , Siegel Rebecca L. , Jemal Ahmedin
Published: April 2023

Supplemental Table 1. Prevalence (%) of current cigarette smoking and use of smokeless tobacco products by gender and race/ethnicity among high school students, Youth Risk Behavior Survey, 2013a.
Supplementary Tables 1, 2, 4 and 5 from The TMPRSS2:ERG Rearrangement, ERG Expression, and Prostate Cancer Outcomes: A Cohort Study and Meta-analysis
Authors: Pettersson Andreas , Graff Rebecca E. , Bauer Scott R. , Pitt Michael J. , Lis Rosina T. , Stack Edward C. , Martin Neil E. , Kunz Lauren , Penney Kathryn L. , Ligon Azra H. , Suppan Catherine , Flavin Richard , Sesso Howard D. , Rider Jennifer R. , Sweeney Christopher , Stampfer Meir J. , Fiorentino Michelangelo , Kantoff Philip W. , Sanda Martin G. , Giovannucci Edward L. , Ding Eric L. , Loda Massimo , Mucci Lorelei A.
Published: April 2023

PDF file, 143K, Characteristics for all men and by ERG-overexpression status among 90 men diagnosed with prostate cancer during transurethral resection of the prostate (TURP)a, PHS and HPFS cohorts 1982-2011.
Supplemental Figure 1 from Prevalence of Major Risk Factors and Use of Screening Tests for Cancer in the United States
Authors: Fedewa Stacey A. , Sauer Ann Goding , Siegel Rebecca L. , Jemal Ahmedin
Published: April 2023

Supplemental Figure 1. Prevalence of current cigarette smoking, high school students.
Supplementary Table 3 from The TMPRSS2:ERG Rearrangement, ERG Expression, and Prostate Cancer Outcomes: A Cohort Study and Meta-analysis
Authors: Pettersson Andreas , Graff Rebecca E. , Bauer Scott R. , Pitt Michael J. , Lis Rosina T. , Stack Edward C. , Martin Neil E. , Kunz Lauren , Penney Kathryn L. , Ligon Azra H. , Suppan Catherine , Flavin Richard , Sesso Howard D. , Rider Jennifer R. , Sweeney Christopher , Stampfer Meir J. , Fiorentino Michelangelo , Kantoff Philip W. , Sanda Martin G. , Giovannucci Edward L. , Ding Eric L. , Loda Massimo , Mucci Lorelei A.
Published: April 2023

XLS file, 43K, List of studies reviewed for but excluded from the meta-analysis.
Supplementary Table 4 from Metabolomics in Epidemiology: Sources of Variability in Metabolite Measurements and Implications
Authors: Sampson Joshua N. , Boca Simina M. , Shu Xiao Ou , Stolzenberg-Solomon Rachael Z. , Matthews Charles E. , Hsing Ann W. , Tan Yu Ting , Ji Bu-Tian , Chow Wong-Ho , Cai Qiuyin , Liu Da Ke , Yang Gong , Xiang Yong Bing , Zheng Wei , Sinha Rashmi , Cross Amanda J. , Moore Steven C.
Published: April 2023

PDF file - 124K, Estimates of π's and ICCs measured among SPA individuals for all identified metabolites in SPA. Only s for all PLCO individuals are listed as replicates were not measured at the same time points.
Table S1-S4 from Metabolic Phenotype and Risk of Colorectal Cancer in Normal-Weight Postmenopausal Women
Authors: Liang Xiaoyun , Margolis Karen L. , Hendryx Michael , Rohan Thomas E. , Groessl Erik J. , Thomson Cynthia A. , Kroenke Candyce H. , Simon Michael S. , Lane Dorothy , Stefanick Marcia , Luo Juhua
Published: April 2023

Table S1. Hazard ratios (HR) and 95% confidence intervals (95% CI) for the association between metabolic phenotype with varied definitions and colorectal/colon cancer among normal-weight women. Table S2. Hazard ratios (HR) and 95% confidence intervals (95% CI) for the association between metabolic phenotype and colorectal/colon cancer among normal-weight women without diabetes. Table S3. Hazard ratios (HR) and 95% confidence intervals (95% CI) for the association between metabolic phenotype and colorectal/colon cancer among WHI normal-weight women without NSAIDs use.
Supplementary Table 2 from Metabolomics in Epidemiology: Sources of Variability in Metabolite Measurements and Implications
Authors: Sampson Joshua N. , Boca Simina M. , Shu Xiao Ou , Stolzenberg-Solomon Rachael Z. , Matthews Charles E. , Hsing Ann W. , Tan Yu Ting , Ji Bu-Tian , Chow Wong-Ho , Cai Qiuyin , Liu Da Ke , Yang Gong , Xiang Yong Bing , Zheng Wei , Sinha Rashmi , Cross Amanda J. , Moore Steven C.
Published: April 2023

PDF file - 46K, A)The proportion of metabolites in each of 10 categories that have an ICC exceeding 0.2, 0.5, and 0.8 in SPA. N is the total number of metabolites within the specified category. B) The proportion of metabolites in each of 10 categories that have an ICC exceeding 0.2, 0.5, and 0.8 in PLCO. N is the total number of metabolites within the specified category.
Table S2 from Night Shift Work Increases the Risks of Multiple Primary Cancers in Women: A Systematic Review and Meta-analysis of 61 Articles
Authors: Yuan Xia , Zhu Chenjing , Wang Manni , Mo Fei , Du Wei , Ma Xuelei
Published: April 2023

Supplementary Table 2. ORs of the common cancers in female nurses
Table S1 from Night Shift Work Increases the Risks of Multiple Primary Cancers in Women: A Systematic Review and Meta-analysis of 61 Articles
Authors: Yuan Xia , Zhu Chenjing , Wang Manni , Mo Fei , Du Wei , Ma Xuelei
Published: April 2023

Supplementary Table 1. ORs of the common cancers in women
Supplementary Figure 4 from Metabolomics in Epidemiology: Sources of Variability in Metabolite Measurements and Implications
Authors: Sampson Joshua N. , Boca Simina M. , Shu Xiao Ou , Stolzenberg-Solomon Rachael Z. , Matthews Charles E. , Hsing Ann W. , Tan Yu Ting , Ji Bu-Tian , Chow Wong-Ho , Cai Qiuyin , Liu Da Ke , Yang Gong , Xiang Yong Bing , Zheng Wei , Sinha Rashmi , Cross Amanda J. , Moore Steven C.
Published: April 2023

PDF file - 22K, Each metabolite level was normalized by three steps: a) log transforming b) subtracting the mean of the log(metabolite) level c) dividing by the standard deviation of the log(metabolite) level. This figure shows the histogram of all (number of subjects x number of metabolites) normalized levels. The absence of longer tails (e.g. little kurtosis) suggests that taking the log of metabolite levels produced relatively normally distributed measurements.
Figure S1 from Night Shift Work Increases the Risks of Multiple Primary Cancers in Women: A Systematic Review and Meta-analysis of 61 Articles
Authors: Yuan Xia , Zhu Chenjing , Wang Manni , Mo Fei , Du Wei , Ma Xuelei
Published: April 2023

Supplementary Figure 1. Forest plots of the association between night shift work and cancer risk of women.
Supplementary Figure 1 from Metabolomics in Epidemiology: Sources of Variability in Metabolite Measurements and Implications
Authors: Sampson Joshua N. , Boca Simina M. , Shu Xiao Ou , Stolzenberg-Solomon Rachael Z. , Matthews Charles E. , Hsing Ann W. , Tan Yu Ting , Ji Bu-Tian , Chow Wong-Ho , Cai Qiuyin , Liu Da Ke , Yang Gong , Xiang Yong Bing , Zheng Wei , Sinha Rashmi , Cross Amanda J. , Moore Steven C.
Published: April 2023

PDF file - 15K, The correlation between the ICCs measured for the metabolites in both PLCO and SPA.
Supplementary Table 3 from N-acetyltransferase 2 Phenotype, Occupation, and Bladder Cancer Risk: Results from the EPIC Cohort
Authors: Pesch Beate , Gawrych Katarzyna , Rabstein Sylvia , Weiss Tobias , Casjens Swaantje , Rihs Hans-Peter , Ding Hui , Angerer Jürgen , Illig Thomas , Klopp Norman , Bueno-de-Mesquita Bas , Ros Martine M. , Kaaks Rudolf , Chang-Claude Jenny , Roswall Nina , Tjønneland Anne , Overvad Kim , Clavel-Chapelon Françoise , Boutron-Ruault Marie-Christine , Dossus Laure , Boeing Heiner , Weikert Steffen , Trichopoulos Dimitrios , Palli Domenico , Sieri Sabina , Tumino Rosario , Panico Salvatore , Quirós José Ramón , González Carlos , Sánchez Mariá José , Dorronsoro Miren , Navarro Carmen , Barricarte Aurelio , Ljungberg Börje , Johansson Mattias , Ulmert David , Ehrnström Roy , Khaw Kay-Tee , Wareham Nick , Key Timothy J. , Ferrari Pietro , Romieu Isabelle , Riboli Elio , Brüning Thomas , Vineis Paolo
Published: April 2023

PDF - 63KB, NAT2 variants and bladder cancer risk for 607 cases and 695 controls nested in EPIC.
Figure S2 from Cellular Expression of PD-L1 in the Peripheral Blood of Lung Cancer Patients is Associated with Worse Survival
Authors: Boffa Daniel J. , Graf Ryon P. , Salazar Michelle C. , Hoag Jessica , Lu David , Krupa Rachel , Louw Jessica , Dugan Lyndsey , Wang Yipeng , Landers Mark , Suraneni Mahipal , Greene Stephanie B. , Magaña Marisa , Makani Samir , Bazhenova Lyudmila , Dittamore Ryan V. , Nieva Jorge
Published: April 2023

Circulating Cells Associated with Malignancy (CCAM) Enumeration by Histology and Stage.
Supplementary Figure 4 from Adult Stature and Risk of Cancer at Different Anatomic Sites in a Cohort of Postmenopausal Women
Authors: Kabat Geoffrey C. , Anderson Matthew L. , Heo Moonseong , Hosgood H. Dean , Kamensky Victor , Bea Jennifer W. , Hou Lifang , Lane Dorothy S. , Wactawski-Wende Jean , Manson JoAnn E. , Rohan Thomas E.
Published: April 2023

PDF - 67KB, Association of height with risk of lung cancer in ever smokers by level of potential effect modifiers. HR4s are adjusted for covariates in footnote 6 in Table 3.
Supplementary Table 4 from Oral Contraceptive Use and Risk of Breast, Cervical, Colorectal, and Endometrial Cancers: A Systematic Review
Authors: Gierisch Jennifer M. , Coeytaux Remy R. , Urrutia Rachel Peragallo , Havrilesky Laura J. , Moorman Patricia G. , Lowery William J. , Dinan Michaela , McBroom Amanda J. , Hasselblad Vic , Sanders Gillian D. , Myers Evan R.
Published: April 2023

PDF - 139KB, Study characteristics and association between OC use and endometrial cancer incidence.
Supplementary Table 1 from Oral Contraceptive Use and Risk of Breast, Cervical, Colorectal, and Endometrial Cancers: A Systematic Review
Authors: Gierisch Jennifer M. , Coeytaux Remy R. , Urrutia Rachel Peragallo , Havrilesky Laura J. , Moorman Patricia G. , Lowery William J. , Dinan Michaela , McBroom Amanda J. , Hasselblad Vic , Sanders Gillian D. , Myers Evan R.
Published: April 2023

PDF - 231KB, Study characteristics and association between OC use and breast cancer incidence.
Supplementary Figure 9 from Sex Disparities in Cancer Mortality and Survival
Authors: Cook Michael B. , McGlynn Katherine A. , Devesa Susan S. , Freedman Neal D. , Anderson William F.
Published: April 2023

PDF file - 102K
Supplementary Figure 8 from Sex Disparities in Cancer Mortality and Survival
Authors: Cook Michael B. , McGlynn Katherine A. , Devesa Susan S. , Freedman Neal D. , Anderson William F.
Published: April 2023

PDF file - 96K
Supplementary Figure 6 from Sex Disparities in Cancer Mortality and Survival
Authors: Cook Michael B. , McGlynn Katherine A. , Devesa Susan S. , Freedman Neal D. , Anderson William F.
Published: April 2023

PDF file - 98K
Supplementary Figure 33 from Sex Disparities in Cancer Mortality and Survival
Authors: Cook Michael B. , McGlynn Katherine A. , Devesa Susan S. , Freedman Neal D. , Anderson William F.
Published: April 2023

PDF file - 102K
Supplementary Figure 28 from Sex Disparities in Cancer Mortality and Survival
Authors: Cook Michael B. , McGlynn Katherine A. , Devesa Susan S. , Freedman Neal D. , Anderson William F.
Published: April 2023

PDF file - 94K
Supplementary Figure 27 from Sex Disparities in Cancer Mortality and Survival
Authors: Cook Michael B. , McGlynn Katherine A. , Devesa Susan S. , Freedman Neal D. , Anderson William F.
Published: April 2023

PDF file - 96K
Supplementary Figure 2 from Epstein–Barr Virus Serology as a Potential Screening Marker for Nasopharyngeal Carcinoma among High-Risk Individuals from Multiplex Families in Taiwan
Authors: Coghill Anna E. , Hsu Wan-Lun , Pfeiffer Ruth M. , Juwana Hedy , Yu Kelly J. , Lou Pei-Jen , Wang Cheng-Ping , Chen Jen-Yang , Chen Chien-Jen , Middeldorp Jaap M. , Hildesheim Allan
Published: April 2023

PDF file - 50K, ROC curve for combined VCAp18 + EBNA1 IgA marker (delta=0.98).
Supplementary Figure 26 from Sex Disparities in Cancer Mortality and Survival
Authors: Cook Michael B. , McGlynn Katherine A. , Devesa Susan S. , Freedman Neal D. , Anderson William F.
Published: April 2023

PDF file - 101K
Supplementary Figure 1 from Epstein–Barr Virus Serology as a Potential Screening Marker for Nasopharyngeal Carcinoma among High-Risk Individuals from Multiplex Families in Taiwan
Authors: Coghill Anna E. , Hsu Wan-Lun , Pfeiffer Ruth M. , Juwana Hedy , Yu Kelly J. , Lou Pei-Jen , Wang Cheng-Ping , Chen Jen-Yang , Chen Chien-Jen , Middeldorp Jaap M. , Hildesheim Allan
Published: April 2023

PDF file - 49K, ROC curve for VCAp18 IgA marker (delta=0.08).
Supplementary Figure S1 from International Variation in Female Breast Cancer Incidence and Mortality Rates
Authors: DeSantis Carol E. , Bray Freddie , Ferlay Jacques , Lortet-Tieulent Joannie , Anderson Benjamin O. , Jemal Ahmedin
Published: April 2023

International variation in age-standardized female breast cancer incidence and mortality rates, 2012
Supplementary Tables 1 - 3 from The PALB2 Gene Is a Strong Candidate for Clinical Testing in BRCA1- and BRCA2-Negative Hereditary Breast Cancer
Authors: Janatova Marketa , Kleibl Zdenek , Stribrna Jana , Panczak Ales , Vesela Kamila , Zimovjanova Martina , Kleiblova Petra , Dundr Pavel , Soukupova Jana , Pohlreich Petr
Published: April 2023

PDF file - 118K, Supplementary Table S1. PCR and sequencing primers. Supplementary Table S2. Identified missense variants in PALB2 gene not previously reported. Supplementary Table S3. Frequency of mutations in the BRCA1, BRCA2 and PALB2 genes identified in our high-risk patients.
Supplementary Figure 20 from Sex Disparities in Cancer Mortality and Survival
Authors: Cook Michael B. , McGlynn Katherine A. , Devesa Susan S. , Freedman Neal D. , Anderson William F.
Published: April 2023

PDF file - 182K
Supplementary Figure 17 from Sex Disparities in Cancer Mortality and Survival
Authors: Cook Michael B. , McGlynn Katherine A. , Devesa Susan S. , Freedman Neal D. , Anderson William F.
Published: April 2023

PDF file - 89K
Supplementary Figure 10 from Sex Disparities in Cancer Mortality and Survival
Authors: Cook Michael B. , McGlynn Katherine A. , Devesa Susan S. , Freedman Neal D. , Anderson William F.
Published: April 2023

PDF file - 96K
Supplementary Table 1 from Biomarkers of Tobacco Exposure: Summary of an FDA-Sponsored Public Workshop
Authors: Chang Cindy M. , Edwards Selvin H. , Arab Aarthi , Del Valle-Pinero Arseima Y. , Yang Ling , Hatsukami Dorothy K.
Published: April 2023

Supplementary Table 1. Discussion Questions for Presenters and Panelists.
Supplementary Table 1 from HPV Type Attribution in High-Grade Cervical Lesions: Assessing the Potential Benefits of Vaccines in a Population-Based Evaluation in the United States
Authors: Hariri Susan , Unger Elizabeth R. , Schafer Sean , Niccolai Linda M. , Park Ina U. , Bloch Karen C. , Bennett Nancy M. , Steinau Martin , Johnson Michelle L. , Markowitz Lauri E.
Published: April 2023

Supplemental Table 1. Multivariable analysis of prevalence of HPV31/33/45/52/58-attributable CIN2+ lesions among women aged 18-39 years, HPV-IMPACT, 2008-2011
Table S5 from Inherited Genetic Variants Associated with Occurrence of Multiple Primary Melanoma
Authors: Gibbs David C. , Orlow Irene , Kanetsky Peter A. , Luo Li , Kricker Anne , Armstrong Bruce K. , Anton-Culver Hoda , Gruber Stephen B. , Marrett Loraine D. , Gallagher Richard P. , Zanetti Roberto , Rosso Stefano , Dwyer Terence , Sharma Ajay , La Pilla Emily , From Lynn , Busam Klaus J. , Cust Anne E. , Ollila David W. , Begg Colin B. , Berwick Marianne , Thomas Nancy E.
Published: April 2023

Table S5. Genotype and haplotype associations with multiple primary melanoma stratified by phenotypic index and back nevi in the GEM study
Supplementary Appendix 1 from A Simulation Model to Predict the Impact of Prophylactic Surgery and Screening on the Life Expectancy of BRCA1 and BRCA2 Mutation Carriers
Authors: Sigal Bronislava M. , Munoz Diego F. , Kurian Allison W. , Plevritis Sylvia K.
Published: April 2023

PDF file, 124KB, Estimation of Age-Specific Breast Cancer Incidence among BRCA1/2 Mutation Carriers in the Absence of Risk-Reducing Interventions.
Table S2 from Inherited Genetic Variants Associated with Occurrence of Multiple Primary Melanoma
Authors: Gibbs David C. , Orlow Irene , Kanetsky Peter A. , Luo Li , Kricker Anne , Armstrong Bruce K. , Anton-Culver Hoda , Gruber Stephen B. , Marrett Loraine D. , Gallagher Richard P. , Zanetti Roberto , Rosso Stefano , Dwyer Terence , Sharma Ajay , La Pilla Emily , From Lynn , Busam Klaus J. , Cust Anne E. , Ollila David W. , Begg Colin B. , Berwick Marianne , Thomas Nancy E.
Published: April 2023

Table S2. Locations of genotypes, minor/major allele, minor allele frequencies, and numbers of samples genotyped in the GEM study and references for the association of the genotypes with melanoma
Supplementary Table 2 from Exposure to Infections and Risk of Leukemia in Young Children
Authors: Marcotte Erin L. , Ritz Beate , Cockburn Myles , Yu Fei , Heck Julia E.
Published: April 2023

PDF file - 222K, Analysis of age at First Exposure to an RSV Season in a Study of Leukemia Risk Among California Children Diagnosed Between 1999 and 2007.
Supplementary Table S2 from Aspirin Use and Risk of Breast Cancer: Systematic Review and Meta-analysis of Observational Studies
Authors: Zhong Shanliang , Chen Lin , Zhang Xiaohui , Yu Dandan , Tang Jinhai , Zhao Jianhua
Published: April 2023

Methodological quality of the case-control studies, based on the NOS for assessing the quality of epidemiological studies.
Supplementary Table 1 from Serum Proteoglycans as Prognostic Biomarkers of Hepatocellular Carcinoma in Patients with Alcoholic Cirrhosis
Authors: Nault Jean-Charles , Guyot Erwan , Laguillier Christelle , Chevret Sylvie , Ganne-Carrie Nathalie , N'Kontchou Gisèle , Beaugrand Michel , Seror Olivier , Trinchet Jean-Claude , Coelho Jessica , Lasalle Philippe , Charnaux Nathalie , Delehedde Maryse , Sutton Angela , Nahon Pierre
Published: April 2023

PDF file - 72K, Clinical and biological variables associated with overall mortality and recurrence-free survival in patients with early HCC based on Cox univariable and multivariable models.
Editorial from Specialty Supplement Use and Biologic Measures of Oxidative Stress and DNA Damage
Authors: Kantor Elizabeth D. , Ulrich Cornelia M. , Owen Robert W. , Schmezer Peter , Neuhouser Marian L. , Lampe Johanna W. , Peters Ulrike , Shen Danny D. , Vaughan Thomas L. , White Emily
Published: April 2023

Editorial from Specialty Supplement Use and Biologic Measures of Oxidative Stress and DNA Damage
Supplementary Tables S1-S3 and Figure S1-S3. from Metabolomic Characterization of Hepatocellular Carcinoma in Patients with Liver Cirrhosis for Biomarker Discovery
Authors: Di Poto Cristina , Ferrarini Alessia , Zhao Yi , Varghese Rency S. , Tu Chao , Zuo Yiming , Wang Minkun , Nezami Ranjbar Mohammad R. , Luo Yue , Zhang Chi , Desai Chirag S. , Shetty Kirti , Tadesse Mahlet G. , Ressom Habtom W.
Published: April 2023

Table S1. List of analytes monitored in the targeted GC-SIM-MS analysis. Table S2. Original and recovered metabolites from KEGG database. Table S3. Pathway enrichment analysis by the use of MetaboAnalyst 3.0. Figure S1. Correlation graph for the HCC cases. This graph is used to investigate the associations among the eleven metabolites selected by LASSO with HCC cases. Figure S2. Correlation graph for the cirrhotic controls. Figure S3. Hidden metabolites discovered from KEGG database for shared connections among HCC and cirrhotic GGM networks.
Table S2 from Cancer-Directed Therapy and Hospice Care for Metastatic Cancer in American Indians and Alaska Natives
Authors: Shiovitz Stacey , Bansal Aasthaa , Burnett-Hartman Andrea N. , Karnopp Andrew , Adams Scott V. , Warren-Mears Victoria , Ramsey Scott D.
Published: April 2023

Table S2. Treatment codes used for evaluation of chemotherapy, radiation, surgery, and/or hospice services received.
Supplementary Table 3 from Germline Missense Variants in the BTNL2 Gene Are Associated with Prostate Cancer Susceptibility
Authors: FitzGerald Liesel M. , Kumar Akash , Boyle Evan A. , Zhang Yuzheng , McIntosh Laura M. , Kolb Suzanne , Stott-Miller Marni , Smith Tiffany , Karyadi Danielle M. , Ostrander Elaine A. , Hsu Li , Shendure Jay , Stanford Janet L.
Published: April 2023

PDF - 51K, Summary of the whole-exome sequencing statistics for the 91 members of 19 hereditary prostate cancer families.
Table S1 from Cancer-Directed Therapy and Hospice Care for Metastatic Cancer in American Indians and Alaska Natives
Authors: Shiovitz Stacey , Bansal Aasthaa , Burnett-Hartman Andrea N. , Karnopp Andrew , Adams Scott V. , Warren-Mears Victoria , Ramsey Scott D.
Published: April 2023

Table S1. Cohort Development for a Comparison of American Indians / Alaska Natives and non-Hispanic Whites with Metastatic Cancer.
Supplementary Figure 1 from Age-Period-Cohort Analysis of Primary Bone Cancer Incidence Rates in the United States (1976–2005)
Authors: Anfinsen Kristin P. , Devesa Susan S. , Bray Freddie , Troisi Rebecca , Jonasdottir Thora J. , Bruland Oyvind S. , Grotmol Tom
Published: April 2023

Supplementary Figure 1 from Age-Period-Cohort Analysis of Primary Bone Cancer Incidence Rates in the United States (1976–2005)
Supplementary Figure 5 from Circulating Biomarkers of Tryptophan and the Kynurenine Pathway and Lung Cancer Risk
Authors: Chuang Shu-Chun , Fanidi Anouar , Ueland Per Magne , Relton Caroline , Midttun Øivind , Vollset Stein Emil , Gunter Marc J. , Seckl Michael J. , Travis Ruth C. , Wareham Nicholas , Trichopoulou Antonia , Lagiou Pagona , Trichopoulos Dimitrios , Peeters Petra H.M. , Bueno-de-Mesquita H. Bas , Boeing Heiner , Wientzek Angelika , Kuehn Tilman , Kaaks Rudolf , Tumino Rosario , Agnoli Claudia , Palli Domenico , Naccarati Alessio , Aicua Eva Ardanaz , Sánchez María-José , Quirós José Ramón , Chirlaque María-Dolores , Agudo Antonio , Johansson Mikael , Grankvist Kjell , Boutron-Ruault Marie-Christine , Clavel-Chapelon Françoise , Fagherazzi Guy , Weiderpass Elisabete , Riboli Elio , Brennan Paul J. , Vineis Paolo , Johansson Mattias
Published: April 2023

PDF file - 113K, Odds ratios with 95% Confidence Intervals (CI) of lung cancer for circulating levels of Tryptophan, Kynurenine and Kynurenine/Tryptophan ratio by smoking status. P for trend were assessed by the base 2 logarithm of the circulating levels.
Supplementary Figure 3 from Circulating Biomarkers of Tryptophan and the Kynurenine Pathway and Lung Cancer Risk
Authors: Chuang Shu-Chun , Fanidi Anouar , Ueland Per Magne , Relton Caroline , Midttun Øivind , Vollset Stein Emil , Gunter Marc J. , Seckl Michael J. , Travis Ruth C. , Wareham Nicholas , Trichopoulou Antonia , Lagiou Pagona , Trichopoulos Dimitrios , Peeters Petra H.M. , Bueno-de-Mesquita H. Bas , Boeing Heiner , Wientzek Angelika , Kuehn Tilman , Kaaks Rudolf , Tumino Rosario , Agnoli Claudia , Palli Domenico , Naccarati Alessio , Aicua Eva Ardanaz , Sánchez María-José , Quirós José Ramón , Chirlaque María-Dolores , Agudo Antonio , Johansson Mikael , Grankvist Kjell , Boutron-Ruault Marie-Christine , Clavel-Chapelon Françoise , Fagherazzi Guy , Weiderpass Elisabete , Riboli Elio , Brennan Paul J. , Vineis Paolo , Johansson Mattias
Published: April 2023

PDF file - 98K, Odds ratios with 95% Confidence Intervals (CI) of lung cancer for circulating levels of Kynurenic acid, 3-Hydroxykynurenine, Anthralinic acid, Xanthurenic acid, 3-Hydroxyantranilic acid and Neopterine. P for trend were assessed by the base 2 logarithm of the circulating levels.
Supplementary Figure 3 from Pectoral Muscle Attenuation as a Marker for Breast Cancer Risk in Full-Field Digital Mammography
Authors: Cheddad Abbas , Czene Kamila , Hall Per , Humphreys Keith
Published: April 2023

Supplementary Figure 3: Volumetric density distributions (VPD) across the different machine types reported in this study.
Supplementary Figure 1 from Pectoral Muscle Attenuation as a Marker for Breast Cancer Risk in Full-Field Digital Mammography
Authors: Cheddad Abbas , Czene Kamila , Hall Per , Humphreys Keith
Published: April 2023

Supplementary Figure 1: MIP distributions across the different machine types reported in this study.
Supplementary Table S3 from Messages to Motivate Human Papillomavirus Vaccination: National Studies of Parents and Physicians
Authors: Malo Teri L. , Gilkey Melissa B. , Hall Megan E. , Shah Parth D. , Brewer Noel T.
Published: April 2023

Correlates of parents' favorable perceptions of messages intended to encourage HPV vaccine uptake, adjusted for child's vaccination status and parent income.
Supplementary Table S2 from Messages to Motivate Human Papillomavirus Vaccination: National Studies of Parents and Physicians
Authors: Malo Teri L. , Gilkey Melissa B. , Hall Megan E. , Shah Parth D. , Brewer Noel T.
Published: April 2023

Parents' endorsement of messages as persuasive stratified by HPV vaccine intention, among those whose child was not previously vaccinated (n = 809).
Supplementary Methods from Population Distribution of Lifetime Risk of Ovarian Cancer in the United States
Authors: Pearce Celeste Leigh , Stram Daniel O. , Ness Roberta B. , Stram Douglas A. , Roman Lynda D. , Templeman Claire , Lee Alice W. , Menon Usha , Fasching Peter A. , McAlpine Jessica N. , Doherty Jennifer A. , Modugno Francesmary , Schildkraut Joellen M. , Rossing Mary Anne , Huntsman David G. , Wu Anna H. , Berchuck Andrew , Pike Malcolm C. , Pharoah Paul D.P.
Published: April 2023

Supplemental Methods: to be published with the manuscript.
Supplementary figure 1 from A Newly Identified Susceptibility Locus near FOXP1 Modifies the Association of Gastroesophageal Reflux with Barrett's Esophagus
Authors: Dai James Y. , de Dieu Tapsoba Jean , Buas Matthew F. , Onstad Lynn E. , Levine David M. , Risch Harvey A. , Chow Wong-Ho , Bernstein Leslie , Ye Weimin , Lagergren Jesper , Bird Nigel C. , Corley Douglas A. , Shaheen Nicholas J. , Wu Anna H. , Reid Brian J. , Hardie Laura J. , Whiteman David C. , Vaughan Thomas L.
Published: April 2023

Supplementary Figure S1. NIH Roadmap Epigenome Atlas characterization of genomic regions flanking rs2687201.
Supplementary Tables 1-2 from Prediagnostic 25-Hydroxyvitamin D, VDR and CASR Polymorphisms, and Survival in Patients with Colorectal Cancer in Western European Populations
Authors: Fedirko Veronika , Riboli Elio , Tjønneland Anne , Ferrari Pietro , Olsen Anja , Bueno-de-Mesquita H. Bas , van Duijnhoven Fränzel J.B. , Norat Teresa , Jansen Eugène H.J.M. , Dahm Christina C. , Overvad Kim , Boutron-Ruault Marie-Christine , Clavel-Chapelon Françoise , Racine Antoine , Lukanova Annekatrin , Teucher Birgit , Boeing Heiner , Aleksandrova Krasimira , Trichopoulou Antonia , Benetou Vassiliki , Trichopoulos Dimitrios , Grioni Sara , Vineis Paolo , Panico Salvatore , Palli Domenico , Tumino Rosario , Siersema Peter D. , Peeters Petra H. , Skeie Guri , Brustad Magritt , Chirlaque Maria-Dolores , Barricarte Aurelio , Ramón Quirós Jose , Sánchez Maria José , Dorronsoro Miren , Bonet Catalina , Palmqvist Richard , Hallmans Göran , Key Timothy J. , Crowe Francesca , Khaw Kay-Tee , Wareham Nick , Romieu Isabelle , McKay James , Wark Petra A. , Romaguera Dora , Jenab Mazda
Published: April 2023

PDF file - 104K
Supplementary Table 2 from The Stem Cell Factor HMGA2 Is Expressed in Non-HPV–Associated Head and Neck Squamous Cell Carcinoma and Predicts Patient Survival of Distinct Subsites
Authors: Günther Kathrin , Foraita Ronja , Friemel Juliane , Günther Frauke , Bullerdiek Jörn , Nimzyk Rolf , Markowski Dominique Nadine , Behrens Thomas , Ahrens Wolfgang
Published: April 2023

Cox regression models for overall, tumor-specific and progression-free survival time (only HPV-negative cases)
Supplementary Table 1 from The Stem Cell Factor HMGA2 Is Expressed in Non-HPV–Associated Head and Neck Squamous Cell Carcinoma and Predicts Patient Survival of Distinct Subsites
Authors: Günther Kathrin , Foraita Ronja , Friemel Juliane , Günther Frauke , Bullerdiek Jörn , Nimzyk Rolf , Markowski Dominique Nadine , Behrens Thomas , Ahrens Wolfgang
Published: April 2023

Cox regression models for overall survival time. Comparison of different cut-offs for HMGA2 expression
Supplemental Table 1 from A Nomogram Derived by Combination of Demographic and Biomarker Data Improves the Noninvasive Evaluation of Patients at Risk for Bladder Cancer
Authors: Huang Sijia , Kou Lei , Furuya Hideki , Yu Changhong , Goodison Steve , Kattan Michael W. , Garmire Lana , Rosser Charles J.
Published: April 2023

Demographics related to study cohort
Table 1 from Prior Autoimmune Disease and Risk of Monoclonal Gammopathy of Undetermined Significance and Multiple Myeloma: A Systematic Review
Authors: McShane Charlene M. , Murray Liam J. , Landgren Ola , O'Rorke Michael A. , Korde Neha , Kunzmann Andrew T. , Ismail Mohammad Roshidi , Anderson Lesley A.
Published: April 2023

Table 1. Summary characteristics of studies included within meta-analysis of autoimmune disease and subsequent risk of myeloma
Supplemental Table 2 from Approach for Classification and Severity Grading of Long-term and Late-Onset Health Events among Childhood Cancer Survivors in the St. Jude Lifetime Cohort
Authors: Hudson Melissa M. , Ehrhardt Matthew J. , Bhakta Nickhill , Baassiri Malek , Eissa Hesham , Chemaitilly Wassim , Green Daniel M. , Mulrooney Daniel A. , Armstrong Gregory T. , Brinkman Tara M. , Klosky James L. , Krull Kevin R. , Sabin Noah D. , Wilson Carmen L. , Huang I-Chan , Bass Johnnie K. , Hale Karen , Kaste Sue , Khan Raja B. , Srivastava Deo Kumar , Yasui Yutaka , Joshi Vijaya M. , Srinivasan Saumini , Stokes Dennis , Hoehn Mary Ellen , Wilson Matthew , Ness Kirsten K. , Robison Leslie L.
Published: April 2023

Medical Event Grading in SJLIFE
Supplemental Table 1 from Approach for Classification and Severity Grading of Long-term and Late-Onset Health Events among Childhood Cancer Survivors in the St. Jude Lifetime Cohort
Authors: Hudson Melissa M. , Ehrhardt Matthew J. , Bhakta Nickhill , Baassiri Malek , Eissa Hesham , Chemaitilly Wassim , Green Daniel M. , Mulrooney Daniel A. , Armstrong Gregory T. , Brinkman Tara M. , Klosky James L. , Krull Kevin R. , Sabin Noah D. , Wilson Carmen L. , Huang I-Chan , Bass Johnnie K. , Hale Karen , Kaste Sue , Khan Raja B. , Srivastava Deo Kumar , Yasui Yutaka , Joshi Vijaya M. , Srinivasan Saumini , Stokes Dennis , Hoehn Mary Ellen , Wilson Matthew , Ness Kirsten K. , Robison Leslie L.
Published: April 2023

Neuropsychological Event Grading in SJLIFE
Supplementary Figure 1 from A Cross-Cancer Genetic Association Analysis of the DNA Repair and DNA Damage Signaling Pathways for Lung, Ovary, Prostate, Breast, and Colorectal Cancer
Authors: Scarbrough Peter M. , Weber Rachel Palmieri , Iversen Edwin S. , Brhane Yonathan , Amos Christopher I. , Kraft Peter , Hung Rayjean J. , Sellers Thomas A. , Witte John S. , Pharoah Paul , Henderson Brian E. , Gruber Stephen B. , Hunter David J. , Garber Judy E. , Joshi Amit D. , McDonnell Kevin , Easton Doug F. , Eeles Ros , Kote-Jarai Zsofia , Muir Kenneth , Doherty Jennifer A. , Schildkraut Joellen M.
Published: April 2023

Supplemental Figure 1: Manhattan plot, illustrating p-values from 60,297 SNP associations, generated from each of the 10 studies used in the meta-analysis. Statistical significance threshold is denoted by the red line (p = 5.09 x 10-6).
Data from Performance of Three-Biomarker Immunohistochemistry for Intrinsic Breast Cancer Subtyping in the AMBER Consortium
Authors: Allott Emma H. , Cohen Stephanie M. , Geradts Joseph , Sun Xuezheng , Khoury Thaer , Bshara Wiam , Zirpoli Gary R. , Miller C. Ryan , Hwang Helena , Thorne Leigh B. , O'Connor Siobhan , Tse Chiu-Kit , Bell Mary B. , Hu Zhiyuan , Li Yan , Kirk Erin L. , Bethea Traci N. , Perou Charles M. , Palmer Julie R. , Ambrosone Christine B. , Olshan Andrew F. , Troester Melissa A.
Published: April 2023

Abstract
Background: Classification of breast cancer into intrinsic subtypes has clinical and epidemiologic importance. To examine accuracy of IHC-based methods for identifying intrinsic subtypes, a three-biomarker IHC panel was compared with the clinical record and RNA-based intrinsic (PAM50) subtypes.

Methods: Automated scoring of estrogen receptor (ER), progesterone receptor (PR), and HER2 was performed on IHC-stained tissue microarrays comprising 1,920 cases from the African American Breast Cancer Epidemiology and Risk (AMBER) consortium. Multiple cores (1–6/case) were collapsed to classify cases, and automated scoring was compared with the clinical record and to RNA-based subtyping.

Results: Automated analysis of the three-biomarker IHC panel produced high agreement with the clinical record (93% for ER and HER2, and 88% for PR). Cases with low tumor cellularity and smaller core size had reduced agreement with the clinical record. IHC-based definitions had high agreement with the clinical record regardless of hormone receptor positivity threshold (1% vs. 10%), but a 10% threshold produced highest agreement with RNA-based intrinsic subtypes. Using a 10% threshold, IHC-based definitions identified the basal-like intrinsic subtype with high sensitivity (86%), although sensitivity was lower for luminal A, luminal B, and HER2-enriched subtypes (76%, 40%, and 37%, respectively).

Conclusion: Three-biomarker IHC-based subtyping has reasonable accuracy for distinguishing basal-like from nonbasal-like, although additional biomarkers are required for accurate classification of luminal A, luminal B, and HER2-enriched cancers.

Impact: Epidemiologic studies relying on three-biomarker IHC status for subtype classification should use caution when distinguishing luminal A from luminal B and when interpreting findings for HER2-enriched cancers. Cancer Epidemiol Biomarkers Prev; 25(3); 470–8. ©2015 AACR.
Data from No Association between Ovarian Cancer Susceptibility Variants and Breast Cancer Risk among Chinese Women
Authors: Ma Xiangyu , Cai Qiuyin , Delahanty Ryan J. , Shu Xiao-Ou , Zhang Ben , Lu Wei , Gao Yu-Tang , Zheng Wei , Long Jirong , Beeghly-Fadiel Alicia
Published: April 2023

Abstract
Background: As breast and ovarian cancers may have similar etiologies, this study aimed to evaluate the hypothesis that breast cancer shares common genetic susceptibility variants with ovarian cancer.

Methods: Ten genetic variants in nine loci were previously identified to be associated with ovarian cancer risk among Caucasian women; an additional 353 variants in high-linkage disequilibrium (r2 ≥ 0.6) among Han Chinese were identified. Data were available from the Affymetrix Genome-Wide Array (6.0) or MACH imputation for 25 and 78 common genetic variants [minor allele frequency (MAF) ≥0.05], respectively. Associations with breast cancer risk were evaluated by additive logistic regression models among 2,918 breast cancer cases and 2,324 controls.

Results: No associations with breast cancer risk were evident for 103 ovarian cancer susceptibility variants in five loci. Four loci were not evaluated, as they included only rare variants (MAF < 0.05).

Conclusions: Ovarian cancer susceptibility variants identified in Caucasian women were not associated with breast cancer risk among 5,242 Chinese women.

Impact: These findings suggest that breast and ovarian cancer may not share common susceptibility variants among Chinese women. Cancer Epidemiol Biomarkers Prev; 22(3); 467–9. ©2013 AACR.
Data from PIWI-Interacting RNAs in Gliomagenesis: Evidence from Post-GWAS and Functional Analyses
Authors: Jacobs Daniel I. , Qin Qin , Lerro Michael C. , Fu Alan , Dubrow Robert , Claus Elizabeth B. , DeWan Andrew T. , Wang Guilin , Lin Haifan , Zhu Yong
Published: April 2023

Abstract
Background: PIWI-interacting RNAs (piRNAs), the largest class of noncoding RNAs in mammals, cooperate with PIWI proteins to safeguard the genome from insertional mutations during germline development. Although a growing number of studies have linked the PIWI–piRNA pathway to carcinogenesis, the role of piRNAs in glioma has not been explored.

Methods: Utilizing directly measured and imputed genotypes from the GliomaScan genome-wide association study (1,840 cases and 2,401 controls), genetic variants in 1,428 piRNAs were analyzed for association with glioma risk. In vitro assays were performed to interrogate the functional impact of a top identified piRNA and its variant allele.

Results: Variants in five piRNAs were considered to be associations of interest and four of these showed narrow clusters of enhanced association signals surrounding the index variant. Functional analyses of one of these piRNAs, piR-598, revealed that transfection of the wild-type piRNA impacted expression of genes involved in cell death/survival and reduced glioma cell viability and colony formation. However, upon delivery of piR-598 containing the variant allele at rs147061479 [OR, 1.80; 95% confidence interval (CI), 1.33–2.46; P = 1.69 × 10−4], cell proliferation was sharply increased.

Conclusions: The genetic association analysis identifies several piRNAs associated with glioma risk, and follow-up functional analyses suggest that variant rs147061479 in piR-598 increases glioma risk by abolishing the tumor-suppressive function of piR-598, instead conferring growth-promoting properties.

Impact: This transdisciplinary study demonstrates a role of piRNAs in gliomagenesis by evidence from both post-GWAS and in vitro functional analyses and supports expanded investigation into the link between the PIWI–piRNA pathway and cancer. Cancer Epidemiol Biomarkers Prev; 25(7); 1073–80. ©2016 AACR.