bluuebunny/crossref_metadata_2025 huggingface dataset:
Current Regulations for Marketing Authorization and Procedure for Filing of Active Substance Master File (ASMF) in European Union: A Case Study
Authors: Henry Miranda Marlon Ramcy , Charyulu R Narayana , Jose Jobin , DS Sandeep
Published: June 2022

Active Pharmaceutical Ingredient is an ingredient in a drug product that is biologically active. A Drug Product will contain two components, one is the Active Ingredient and the other is the Excipients part. Drug Product that has to be placed in the European market needs to have a marketing authorization. Marketing Authorization is the process in which the drug product is evaluated for its safety and compliance with the standards laid down by the Regulatory Authority, considering the safety of patients and public. There are different Procedures for the application of Marketing Authorization. Applicants can either apply for marketing authorization through centralized procedure, decentralized procedure, mutual recognition procedure or the nationalized procedure. Active Substance Master File (ASMF) is a Regulatory Dossier that helps provide confidential data pertaining to the Active Substance to the regulatory authority. This master file shall contain data from the research of the product to the development and lifecycle of the product. ASMF contains two parts, the restricted part and the open part. Both of these parts of ASMF shall not be shared to anyone without a written consent from the ASMF Holder. This master file makes it easy for the application of any Marketing authorization and also makes it easy for the regulators to access all the required data. European Union thus has laid down many Regulations and guidelines for the application of Marketing Authorization and also on how an ASMF is filed in European Union. The current work aims at methodically analyzing the guidance documents that are available and thus help in the review of regulations for the application of Marketing Authorization and also in knowing the process for the filing of Active Substance Master File (ASMF) in the European Market.
Analysis of Water Quality by Physico-Chemical Parameters of Jhunjhunu City, Rajasthan
Authors: Kumari Anita , Gupta Y.K.
Published: June 2022

Tube wells water is increasingly being sought as a supply of ingesting water because of the shortage, non-availability and bacteriological pollutants of floor water. This paper describes the vital results of the Physico-chemical evaluation of the tube wells water samples of the rural areas in Churela, District – Jhunjhunu of Rajasthan State. The special parameters determined are pH, TDS, fluoride, chloride, nitrate, sulphate, overall alkalinity and overall hardness. It has been discovered that nitrate values are better compared to ICMR requirements. Other parameters had been determined inside appropriate limits. As a result the analysis of the water pleasant is very important to maintain and prefect the natural eco system. The examine of physico-chemical and biological characteristics of this tube wells water samples indicates that the evaluation of water nice parameters in addition to water pleasant control practices ought to be accomplished periodically to shield the water sources.
Virgin Coconut Oil Emulgel: Effect of VCO and Carbopol 940 Concentration on Characterization and Antibacterial Activity
Authors: Melani Hariyadi Dewi , Rosita Noorma , Isnaeni Isnaeni , Sudarma Sisunandar , Rezania Deavisca
Published: June 2022

Virgin coconut oil (VCO) is mostly produced from Cocos nucifera L. Kopyor coconut from Cocos nucifera L.is a coconut that has fruit flesh apart from its shell with mainly consist of lauric acid, vitamin C and α-tocopherol as antioxidants. Kopyor coconut has high lauric acid content in the flesh or VCO and has been found effective against Propionibacterium acnes bacteria. To increase its acceptability as anti-acne or skin diseases, VCO of kopyor coconut was formulated into emulgel. VCO concentration as the active agent was used of 20% and 30%. A selected gelling agent was Carbopol 940 at concentration of 1% and 2%. The emulgel then evaluated for physical characterization such as viscosity, pH, spreadability, particle size, particle size distribution, and zeta potential. The emulgel was also tested for antibacterial activity against Propionibacterium acnes and stability tests using thermal cycling method. The selected formula was formula 4 that had good zeta potential, suitable with skin pH, had a good particle size and distribution and was effective against Propionibacterium acnes bacteria.
Status of Zinc, Iron and some Biochemical Parameters in patients with Polycythemia
Authors: Al - Zuhairi Wafaa Sh. , Abdallah Hassan Ekhlas , Ibrahim Abdulmajeed Alzahraa
Published: June 2022

The goal of this study is to determine the concentration of total zinc, iron, ESR, PCV, Hb, CBC in the serum of patients with polycythemia vera. These results are indicated that age of patient and control group Iraq males are to some extend similar. Whereas, average value of ESR ±SD for patient and control groups were (8.36± 4.41) and (15.40± 5.10), respectively. It was clearly indicated that ESR for patient higher than control group. The erythrocyte sedimentation rate (ESR) is decreased due to an increase in zeta potential. While, the average iron ±SD for patient and control group were (35.12 ± 8.21) and (23.48 ± 2.40) respectively. The level of zinc shows no significant difference between polycythemic and control gropes. Also show that there was a highly significance in packed cell volume between patient groups (51.49±4.62) when compared with control groups (36.30±3.22). The mean ±SD of Hb and WBC for patient and control group were (16.08 ± 1.14) (12.40 ± 0.68) and (12.04 ± 3.17) (8.21 ± 1.48) respectively. These results are showed that Hb, WBC of patient strongly higher compering to control group (p>0.05). the majority of patients were at the age between (41-50) years with percentage of (30.76%), (31-40) years with a percentage (25.64%) and (20-30) years with a percentage (23.07%). While age groups between (51-60) years were (12.82%) and age groups (>60) years were (7.7%). The result show that (2.5) percent of patients had PCV level less than normal, (38.5) percent of patients had normal level and (59) percent of patients showed concentration more than normal as shown in (Table 4). There are (5.1) percent of patients showed level less than normal, (53.8) percent of patients had normal level and (41) percent of patients showed concentration more than normal. The current study has been shown that the concentration of biochemical parameters is influenced by polycythemia.
Anencephaly is a complicated and perplexing situation
Authors: Lwin Soe , San Yi Myat , Anayath Indulekha , Naz Farah , Than Yee Khin , Moe Nwe Tin
Published: June 2022

Anencephaly means simply no brain or acrania. To be precise, it is a congenital absence of the skull, scalp, and forebrain (cerebral hemispheres). It was categorized under neural tube defects (NTD). As a whole, NTD is the second most common fatal anomaly after cardiac defects. The neural tube defects are a group of central nervous system ailments, which result from the failure of normal primary neurulation, an embryologic process completes in humans by almost day 26-28 the post-conception. In this case, the normal closure of the anterior neuropore fails, which results in anencephaly. The case report demonstrates the clinical experience that would broaden our knowledge of this uncommon but distressing and dilemmatic event. We highlighted the ultrasound features to recognize the condition by first and second-trimester scans and the role of folic acid in the prevention of further occurrence. The diagnosis was confirmed anencephaly with formal ultrasound from the radiologist, who reported no definite brain parenchyma noted, the head was small in size, and the patient was informed about the condition and its prognosis. The reported case was found to be rare and clinicians emphasized the contribution of professional guidance for its management since the case is critical and the ethical concerns need careful handling to avoid adverse psychosocial outcomes such as grief, guilt, anxiety, and loss of self-confidence.
Evaluation of in vitro Free Radical Scavenging and Antidiabetic Activities of Polyherbal formulations
Authors: R. Jothika , M. Sangeetha , N. Jaipratap , Emmanuel C. John Godwin , Narasimha Varma Gokaraju
Published: June 2022

Diabetes mellitus is a group of disorder that raise up the metabolism of carbohydrate, fat and protein. In recent years, it has a prediction of increases in incidence and prevalence of diabetes mellitus. Traditionally various plant parts are used to treat against the diabetes mellitus. The plant Artemisia nilgirica (Asteraceae) is used in the treatment of insecticidal, antimicrobial, antiasthmatic and antiparasitic. Borreria hispida (Rubiaceae) is used as Anti hyperlipidemia, antifungal, anticancer, anti inflammatory. Sida acuta (Malvaceae) is used in the treatment of analgesic, antipyretic, woundhealing antiulcer and antibacterial activity. Artemisia nilgirica, Borreria hispida, Sida acuta were processed, powdered and extracted with hydroalcoholic solvent. Maceration was processed for 72hrs, 48 hrs and 24hrs. Solvents were filtered, distilled and dried in a vacuum desiccator. Formulation SAB, ABS, BSA were made by taking required proportion of each powdered drugs. The in vitro anti- diabetic potential of plant was determined by α - amylase and α – glucosidase inhibition assay. The activity reported that hydroalcoholic extract of Artemisia nilagrica, Borreria hispida, and sida acuta exhibits in dose – dependent manner. The polyherbal formulation will lead to the treatment of diabetic from the natural source with lesser side effect.
Antibacterial Screening of Urine Culture using Urine Antibacterial Substance Assay (UABA)
Authors: S. Subalakshmi , S. S. M. Umamageswari , M. Kalyani
Published: June 2022

Presence of antibacterial activity in urine will reduce the bacterial load in culture plate, leading to “Insignificant Bacteriuria” as a false positive result. UABA (Urine antibacterial substance assay) is therefore performed to make accurate findings.The aim of the study was to check for the antibacterial activity of urine samples obtained from patients in a tertiary care hospital. Total of 100 urine samples were collected and preliminary tests were performed. Antibiotic susceptibility test was performed using Kirby-Bauer disc diffusion assay with the urine samples against the ATCC strains of Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. Zone formation was compared with the growth in the urine culture plate and the corresponding patients antibiotic history. The findings were, out of 100 samples 23 samples were true positive and 50 samples were true negative, 35 samples were UABA positive with culture negativity 8 samples were UABA positive and culture positive. Sensitivity and specificity of the test was found to be 76.66% and 71.42% respectively. This study helps in understanding the importance of performing urine culture and sensitivity testing before starting the antibiotic therapy. False negative results can be reduced to promote flawless diagnosis and speedy recovery.
Development and Validation of Quality by Design based RP-HPLC Method for determination of Tenofovir Alafenamide Fumarate from Bulk drug and Pharmaceutical dosage form and its application to Forced Degradation Studies
Authors: J. Wankhade Aakanksha , D. Hamrapurkar Purnima
Published: June 2022

The present research work entails the development and validation of a simple, robust and sensitive stability indicating reverse phase high performance liquid chromatographic method using Quality by Design methodology for estimation of Tenofovir alafenamide fumarate in bulk drug and its marketed dosage form. Chromatographic separation was performed in isocratic mode using Inertsil C18 column, mobile phase composed of Acetonitrile: ammonium formate buffer pH 5(40: 60) at a flow rate of 1mL/min with Photo Diode Array (PDA) detection at 261nm. A Box-Behnken statistical design with 3 factors and 3 levels was selected for the optimization study. Interaction effects of Critical Quality Parameters (Buffer pH, Organic Phase-% acetonitrile, flow rate) were evaluated for critical quality attributes (Retention time, NTP and symmetry factor). The optimized method was validated according to the current International Conference Harmonization (ICH) Q2 R1 guidelines. The method was found to be linear, covering the range from 1.5 μg/mL – 4.5 μg/mL with correlation coefficient r2 of 0.9996 and precision was found to be less than 2%. Limit of Detection and Limit of Quantification was found to be 1µg/mL and 1.2µg/mL respectively. Accuracy was between 99% and 102%. Forced degradation study was conducted under degradation conditions like light, oxidation, dry heat, acidic, basic, hydrolysis in order to establish the intrinsic stability of molecule. The method was successfully applied for the determination of the drug in commercial dosage form. This holistic stability indicating chromatographic method focused on QbD approach ensured reproducibility and was found to be useful for routine analysis of Tenofovir alafenamide fumarate.
Radical Scavenger and Anti-diabetic Potencies of Etlingera elatior Fruits growing in South East Sulawesi-Indonesia
Authors: Imran Imran , Wahyuni Wahyuni , Fristiohady Adryan , Leorita Mesi , Malaka M. Hajrul , Ilyas Y Muhammad , Musadar Musadar , Rahmatika Nur Syifa , Darmawan Ahmad , Fajriah Sofa , Mahatva Yodha Agung W. , I Sahidin
Published: June 2022

Etlingera elatior have many biological properties. Thus, we aim to isolate and to evaluate radical scavenger potency of compounds from Etlingera elatior fruits and antidiabetic potency of the ethanol fruits extract. E. elatior fruits were collected from the Wolasi Forest, South East Sulawesi. The isolation was carried out by using chromatography technique and the compound structures were evaluated by interpreting spectroscopic data (FTIR, 1H and 13C NMR). The radical scavenger activity was evaluated towards DPPH (1,1-diphenyl 2-picryl-hydrazyl) radicals. Antidiabetic activity was carried out in experimental animals, as well as the histopathology of pancreatic organ. Four aromatic compounds have been isolated and identified, quercetin (1) as flavonoid, firstly reported from E.elatior fruits, p-coumaric acid (2), vanilic acid (3), and p-hydroxybenzoic acid (4). Radical scavenger potency of quercetin> vanilic acid>p-hydroxybenzoic acid>p-coumaric acid> the extract. Ethanol extract of Wualae fruits showed activity as antidiabetic and protective effect to beta cell at concentration 200; 300; and 400mg/kgBw, with most effective in decreasing plasma glucose and protecting beta cell was 400 mg/KgBw. E.elatior fruits possess pronounced radical scavenger and anti-diabetic properties which may be due to the presence quercetin in the plant. Therefore, the fruit’s extract can be further developed for the cosmetics and diabetic management.
Detection of Cytomegalovirus in Urine Specimen of Cholestatic Infants by Polymerase Chain Reaction
Authors: Mastutik Gondo , Kurniasari Nila , Rahniayu Alphania , Setijo Rahaju Anny , N. Ruslan S. Eriaty , Ilmiah Khafidhotul , Setyoboedi Bagus , Sulistyani Erna
Published: June 2022

Cholestatic infants are associated with congenital abnormalities or viral infections, such as cytomegalovirus (CMV) infection. CMV can be detected by polymerase chain reaction (PCR) in body fluids, including urine which can be obtained easily and is non-invasive. The objective was to detect CMV in urine specimens of cholestasis infants and to analyze its correlation with serological status. This was a descriptive observational study with the cross-sectional approach, used urine from 39 cholestatic infants who meet the inclusion and exclusion criteria and have been approved by Ethics Committee. The nested-PCR was performed from extracted urine and unextracted direct urine. Serological data of immunoglobulin (Ig) M and IgG data were collected. Data were analyzed by Chi-square. Detection of CMV from extracted urine by PCR showed positive in 87.2% patients and from unextracted urine was positive in 48.7% patients. Serological status showed that IgM was positive in 41.0% patients and IgG was positive in 89.7% patients. The acute infection (IgM+ IgG+) was found in 41.0% patients, past infection (IgM-IgG+) was 48.7% patients, and not infected (IgM-IgG-) was in 10.3% patients. The acute infection (IgM+ IgG+), past infection (IgM-IgG+) and not infected (IgM-IgG-) was found in 41.0%, 48.7%, and 10.3% patients, respectively. The correlation between PCR CMV from extracted urine with serological CMV was moderate, while the unextracted urine was low. It indicates that to detect the infection of CMV, PCR technique is more accurate than serological testing, and the extracted urine is more appropriate specimen as PCR template than direct urine.
Effect of head covering on Phototherapy Induced Hypocalcemia in Jaundiced term neonates
Authors: G H Laxmipati , Avabratha K Shreedhara , K Bhagyalakshmi
Published: June 2022

The present study was aimed to assess the effect of head covering on phototherapy induced hypocalcaemia in jaundiced term newborns. This study was conducted in a medical college hospital in South India. All enrolled term neonates were randomly allotted to either the group using a cap (cases) or the group not using a cap (controls) by using closed envelope method. Conventional phototherapy equipment was used and the American Academy of Pediatrics (AAP) guidelines for phototherapy were followed. Serum calcium levels were measured before and after 24 hours and after 48 hours of phototherapy in case phototherapy was continued for a longer period. Results were tabulated and analyzed using student t-test and Chi square test. Out of 110 newborns studied, 58(53%) were boys and 52(47%) were girls. The average age of onset of jaundice was between 25- 48 hours. The mean weight of the neonates was 2993±241g. Mean total serum bilirubin level before phototherapy was 13.43±3.27mg/dl. Mean total serum calcium level before phototherapy was 9.92±0.84mg/dl. Mean total serum calcium levels after 24 hours of phototherapy were 9.37±0.67mg/dl and 9.21±0.71mg/dl in cases and controls respectively (p =0.000). Mean total serum calcium levels after 48 hours of phototherapy were 8.87±0.80 mg/dl and 8.52±0.54mg/dl in cases and controls respectively (p=0.022). Only 3 babies in control group developed hypocalcaemia (Serum calcium <8 mg/dl) and none were symptomatic. There is a reduction in the total serum calcium level after phototherapy which is more as the duration of phototherapy is increased. The reduction in the total serum calcium level after phototherapy is significantly less when the head is covered with a cap during phototherapy than when it is not.
Character Education to Improve Students’ Sense of Relatedness: Preliminary Findings from the Positivity Project
Authors: Garwood Justin D.
Published: June 2022

Sense of relatedness is a key component of students’ social-emotional learning, as it captures the degree to which students’ feel they have quality relationships with others in school. The purpose of the current pilot case study is to measure students’ sense of relatedness and assess the degree to which a new character education social-emotional learning program based in positive psychology – The Positivity Project (P2) – is having a positive impact on students. Results from the two case studies including 108 elementary school students and 154 middle school students indicate positive associations between P2 implementation and increases in self-reported sense of relatedness.
Determination of the Nutritional Habits of the Primary Teacher Candidates for the Game and Physical Activities Teaching Course
Authors: Çeviker Arzu Pekğöz , Şekeroğlu Mustafa Önder
Published: June 2022

Today, countries implement policies and programs for childhood obesity. However, the effect of classroom teachers in preventing obesity is in a position to be a role model for students. Therefore, the awareness of the pre-service classroom teachers about nutrition and their nutritional behaviors have an important place on the students. On the other hand, a regular and correct nutrition behavior that the teacher candidates who are trained in the primary school teaching program will receive can gain this behavior to the students they will teach. In addition, there is a balanced and regular eating habit in the physical activity and nutrition section of the Physical Education and Play Lesson Curriculum in primary schools. In this study, it was aimed to examine the dietary habits of primary school teacher candidates. For this purpose, the questionnaire revealing the eating habits was applied to the primary school teacher candidates. In the analysis of the data, percentage and frequency tests were performed with the SPSS program. In the research results; it was discovered that most of the primary school teacher candidates did not receive nutrition education, did not have alcohol and smoking habits, and did not engage in any sports activities. It has been stated that almost all of the primary school teacher candidates have the habit of breakfast, but they skip meals, and the most skipped meal is lunch. They stated that the reason for skipping meals was that they did not have the opportunity. It was seen that the majority of the participants consume less than two liters of water per day and less than five cups of tea/coffee per day. As a result of the study, it was determined that the primary school teacher candidates’ nutritional habits and knowledge levels were deficient.
The Development of the Integrated Curriculum of the Buddhist Morals for Strengthening Social Adaptation of Vulnerable Youth
Authors: Nathpukdee Rachaneeboon , Siriwatthanathakun Natthakit , Kietjarungphan Buncha , Chachikul Prachan , Uthaphan Phattharachai , Promsri Prasong , Kongsumruay Khamphiraphap
Published: June 2022

The purposes of the study consequently were (1) to study background information needed in the development of a Buddhism curriculum in developing vulnerable youths’ social adaptation, (2) to develop a Buddhism curriculum in developing vulnerable youths’ social adaptation, and (3) to implement the Buddhism curriculum in developing vulnerable youths’ social adaptation. The study was divided into 3 phases including need analysis, curriculum development, and curriculum implementation. The participants were 50 stakeholders of vulnerable youth caregivers in phase 1, 5 experts in phase 2, and 100 vulnerable youths in phase 3. The instruments were an interview form, a curriculum evaluation form, an integrated curriculum of the Buddhist morals, and a pre-post test. The data were analyzed using content analysis, percentages, mean scores, standard deviation, and a paired sample t-test. The main findings could be summarized that using the integrated curriculum of the Buddhist morals was beneficial in strengthening the social adaptation of vulnerable youths. However, the developmental processes of the curriculum also demand the analysis of information regarding vulnerable youths, their environment, and potential Buddhism morals that could benefit their life skills. Students also need learning activities that could help them make a connection between religious morals and life situations.
Blended Learning and Creativity-Based Learning for Promoting Mathematics Achievement and Information Technology Performance
Authors: Yonwilad Wannatida , Sinlapaninman Unyaparn
Published: June 2022

This study aimed to develop blended learning activities and creativity-based learning in the Mathematics for Computer Course (MCC), compare mathematics achievement in the MCC at a 70% threshold score, compare students’ information technology usage performance, and investigate students’ learning satisfaction. The participants were freshmen who enrolled in MCC at Kalasin University, academic year 2021. Purposive sampling was employed in the recruitment of 25 students. The research tools included: six activities in the MCC, multiple-choice achievement test with 30 items, the information technology competency assessment form, and a 15-item activity satisfaction scale. The statistics used in the data analysis are descriptive for calculating mean, standard deviation, and percentage, as well as one sample t-test for hypothesis testing. The findings indicated that the academic achievement of students representing 76.67% higher than the specified threshold of 70% with statistical significance at the 0.05 level. Students’ competency in using information technology is 81.67 percent, which is higher than the threshold and they were satisfied with learning approach.
Improving English Pronunciation Skills by Using English Phonetic Alphabet Drills in EFL Students
Authors: Dandee Warinthon , Pornwiriyakit Pornchai
Published: June 2022

This study aims to investigate the improvement of EFL students’ English pronunciation skills by using English phonetic alphabet drills. The samples of this study were 35 first-year students of English for International Communication major, Faculty of Humanities and Social Sciences, Rajamangala University of Technology Tawan-ok. They all registered for the English Pronunciation subject in the second semester. The instruments used for collecting data were English phonetic alphabet drills, English phonetic alphabet collecting forms, observation and focus group interview questions. The data were analyzed both statistically and descriptively. The results showed that all students were able to pronounce English consonant and vowel sounds more accurately after applying English phonetic alphabet drills. However, Nasal /m, n, ŋ/in the final position, and /l/ in the initial and medial position were still the problematic consonant sounds including central vowels, /ʌ/ and /ə/, and the back vowels, /ɒ/, /ʊ/, /u/ and /əʊ/. Students also had difficulties pronouncing voiced sounds. The causes of pronunciation errors were due to differences in the phonological system of the languages, mother tongue interference, and English spelling and pronunciation. From the findings, it was clear that the English phonetic alphabet knowledge could help student improve their English pronunciation.
Analysis of Debt to GDP Ratio with Microeconomic Foundations: Theoretical Basis for MMT Arguments
Authors: Tanaka Yasuhito
Published: June 2022

This paper examines the relationship among budget deficit, inflation rate and debt to GDP ratio from the perspective of Functional Finance Theory and MMT (Modern Monetary Theory). Using an overlapping generations model under monopolistic competition with bequest motive of consumers, mainly we will show the following results. • Under full employment with constant prices or inflation the debt to GDP ratio does not change from a period to the next period • The interest rate on government bonds should equal the nominal growth rate to achieve full employment with constant prices or inflation under balanced budget excluding interest payments on government bonds. • The inflation rate we need to maintain full employment under balanced budget excluding interest payments on government bonds is determined by the interest rate
Abdülkâhir el-Cürcânî'nin Nefsî Kelam Savunusu ve Mu'tezilî Metot Eleştirisi
Authors: YARTAŞI Recep
Published: June 2022

İslâm düşünce geleneğinde Kur’ân’ın yaratılmışlığı etrafında süregelen tartışmalar, kelamın mahiyeti konusunda yeni görüşlerin oluşumuna yol açmıştır. Bu noktada Mu‘tezile, kelamı hâdis kabul ederek onu, fiilî sıfatlar kategorisine yerleştirmiştir. Bu çerçevede onlara göre şâhid âlemdeki kelamın gâibe kıyâs edilmesi metoduna bağlı olarak gâib âlemdeki ilâhî kelam da hâdistir. Bunun aksine Eş‘ariyye mezhebi, Mu‘tezile’nin kelamın hâdis olduğuna dair kanıtlamalarını dikkate almış, lafzî ve nefsî şeklinde ikili bir kelam ayrımıyla ilkeleri doğrultusunda sorunu çözümlemeye çalışmıştır. Söz konusu ayrıma göre hakîkî kelam nefsî kelamdır. İlahî kelamın nefsî boyutunu ispatlamak ise şâhid düzlemdeki kelamın ikili boyutunu ortaya koymaktan geçer. Bu minvalde Eş‘arî mezhebine mensup bir belâgatçı olan Cürcânî, Kur’ân’ın i‘câzı üzerinden insan gerçekliğindeki dil-düşünce ilişkisi çerçevesinde konuyu dilbilimsel bir zemine havale etmiş ve yine hasımlarının metodunu kullanarak beşerî kelama ait özellikleri incelemiş, bu inceleme sonucundaki verileri gayb âleme ilişkin olan ilahi kelamla ilişkilendirme noktasına varmıştır. Onun bu çıkarımı, kıyâsü’l-gâib ale’ş-şâhid yöntemi ile sözü lafızlara indirgeyen ve kelamın nefsî boyutunu reddeden Mu‘tezilî düşünceye şâhid âlemin yanlış anlaşıldığına dair bir eleştiri ve reddiyedir. İşbu çalışmanın amacı, İslâm düşünce geleneğinde kelamın mâhiyetine dair ortaya konan görüşler çerçevesinde Abdülkâhir el-Cürcânî’nin, takip ettiği istidlâl yöntemini incelemek ve onun, Mu‘tezile’nin kelamın mahiyetine dair vardığı sonuca yönelik yöntemsel eleştirisini ele almaktır.
Akın ve Taşkonak Köyleri (Van) Çevresinde Yüzeyleyen Orta-Geç Miyosen Yaşlı Killi Kayaçların Mineralojik Özellikleri ve Paleoiklimsel İpuçları
Authors: YAKUPOĞLU Türker , KAZAK-TAŞTAN Müzeyyen
Published: June 2022

Bu çalışmada Orta-Geç Miyosen yaşlı denizel ortamda oluşmuş olan Van Formasyonu killi kayaçlarının mineralojik özelliklerini belirlemek ve bu kayaçların oluştuğu Orta-Geç Miyosen boyunca çalışma alanındaki eski iklim koşullarını yorumlamak amaçlanmıştır. Çalışma alanı Van Gölü’nün güney batısındadır. Orta-Üst Miyosen kayaçlarından dört stratigrafi kesiti ölçülmüş ve yetmiş üç kilce zengin kayaç numunesi derlenmiştir. Numunelerin tümünün X-ışını difraksiyonu analizleri yapılmış, tüm kayaç bileşimlerinde kuvars, mika, feldispat, kalsit, amfibol, dolomit, kristobalit ve kil mineralleri; kil fraksiyonlarında ise illit, klorit, smektit, serpantin, karışık tabakalı klorit-smektit ve illit-smektit belirlenmiştir. Seçilmiş üç örnek üzerinde yapılan SEM ve EDX çalışmalarında serpantin, klorit ve smektit gözlenmiştir. İyi kristalli illit, smektit, klorit ve feldispat minerallerinin bir arada bulunmalarına dayanılarak, kırıntılı kayaçların oluştuğu süre boyunca bölgede soğuk ve kurak iklim koşullarının hakim olduğu yorumu yapılmıştır.
Zilan Jeotermal Alanının (Erciş-Van) Jeolojisi ve Aktif Tektonik Özellikleri
Authors: SELÇUK Azad Sağlam
Published: June 2022

Doğu Anadolu geçmişten günümüze aktif tektonizma etkisi altında kalarak gelişimini sürdürmektedir. Aktif tektonizma ve volkanizmanın sonucu olarak da bölge orta-yüksek sıcaklıklı kaynak potansiyeline sahiptir. Son yıllarda, jeotermal potansiyeli tanımlanmış Batı Anadolu jeotermal kaynakları; enerji üretimi, konut/şehir ısıtma, termal turizm, seracılık vb. gibi geniş bir yelpazede kullanım olanağı sağlamaktadır. Ancak Doğu Anadolu (DA) jeotermal kaynakları yerel ölçekte sadece termal turizm amacı ve küçük ölçekli seracılık çalışmalarında kullanılmaktadır. Doğu Anadolu Bölgesi’nde günümüze kadar yaklaşık 23 adet jeotermal kaynak belirlenmiştir. Bugüne kadar yapılan çalışmalar sıcak su kaynaklarının çıkış noktaları ile fay hatları arasında bir ilişkinin olduğunu göstermektedir. Yani sıcak su kaynakları kırık hatları boyunca yüzeye ulaşmakta ve konumları da bu hatlara paralellik göstermektedir. KD-GB uzanımlı Erciş-Zilan-Ilıca Vadisi boyunca da yaklaşık 11 adet sıcak su kaynağı bulunup, dizilimleri yaklaşık olarak vadi uzanımına paraleldir. Bu çalışmada, yörede yer alan jeotermal kaynakların, Zilan Fayı ile ilişkisi ortaya konulmaya çalışılmıştır. Sıcak su noktalarının çıkış merkezleri, hassas RTK-GPS aracılığı ile belirlenmiş ve vadi boyunca arazi çalışmaları yapılarak faylanma verisi toplanmıştır. Elde edilen verilere göre Erciş bölgesini ve civarını etkileyebilecek Zilan Fayı’nın, KD-GB uzanımlı sol yanal doğrultu atımlı aktif bir fay olduğu ve bölgede yer alan Zilan jeotermal alanının deformasyonunu denetlediği anlaşılmıştır.
Ekmeklik Buğdaya Salisilik Asit Uygulamasının Çimlenme Döneminde Kuraklık Stresine Etkisinin Belirlenmesi
Authors: YILMAZ Melikşah , KIZILGEÇİ Ferhat
Published: June 2022

Tohum çimlenmesi ve fide oluşumu, bitki büyüme döngüsündeki en hayati aşamadır. Kuraklığa meyilli alanlarda, zayıf tohum çimlenmesi ve fide çıkışı başlıca problemlerdendir. Mevcut araştırma, iki ekmeklik buğday genotipine (DZ17-1 ve Empire Plus) farklı dozlarda salisilik asit uygulamasının çimlenme ve erken gelişim döneminde kuraklık stresine etkilerinin belirlenmesi amacıyla yürütülmüştür. Araştırma Şırnak Üniversitesi Ziraat Fakültesi Tarla Bitkileri Bölümü laboratuvarında tesadüf parsellerinde faktöriyel deneme desenine göre dört tekrarlamalı olarak kurulmuştur. Çalışmada, ekmeklik buğday genotiplerinin tohumlarına 0, 0.5 ve 1 mM SA uygulanmıştır. Tohumlar 5 farklı kuraklık stresi (0, -0.25, -0.50, -0.75, -1 MPa PEG 6000 çözeltisi) ortamında çimlendirilmiştir. Koleoptil uzunluğu, kök uzunluğu, fide boyu, çimlenme hızı ve çimlenme gücü özellikleri incelenmiştir. Araştırma sonuçlarına göre; artan kuraklık stresi incelenen tüm özellikler üzerinde olumsuz etkiye sahip olmuştur. Kuraklık koşullarında sadece 0.5 mM SA uygulaması çimlenme hızı ve çimlenme gücü özelliklerinde artırıcı etkiye sahip olduğu görülmüştür. Empire Plus çeşidinin kuraklık stresine daha toleranslı olduğu belirlenmiştir.
Rezension von: Huber, Peter, Visionär in Zeiten des Umbruchs
Authors: Schweizer Günther , Huber Peter
Published: June 2022

Peter Huber: Visionär in Zeiten des Umbruchs. Johannes Mährlen. Ökonom, Sozialreformer und Freund Mörikes. Hohenheim Verlag Stuttgart 2008. 395 Seiten mit 38 Abbildungen. Gebunden € 22,–. ISBN 978-3-89850-161-3
Rezension von: Butzer, Günter; Jacob, Joachim (Hrsg.), Lexikon literarischer Symbole
Authors: Setzler Markus , Butzer Günter , Jacob Joachim
Published: June 2022

Günter Butzer und Joachim Jacob (Hrsg.): Lexikon literarischer Symbole. Verlag J. B. Metzler Stuttgart 2008. 443 Seiten. Gebunden 39,95. ISBN 978-3-47602-131-1
Rezension von: Röber, Ralph (Hrsg.), Kloster, Dorf und Vorstadt Petershausen
Authors: Wrobbel Sibylle , Röber Ralph
Published: June 2022

Ralph Röber (Hrsg.): Kloster, Dorf und Vorstadt Petershausen. Archäologische, historische und anthropologische Untersuchungen. (Forschungen und Berichte der Archäologie des Mittelalters in Baden-Württemberg, Band 30). Konrad Theiss Verlag Stuttgart 2010. 276 Seiten mit 207 teils farbigen Abbildungen und zahlreichen Tabellen. Gebunden € 54,–. ISBN 978-3-8062-2337-8
Rezension von: Rottenburg im Nationalsozialismus
Authors: Setzler Wilfried , Stadtarchiv (Rottenburg am Neckar)
Published: June 2022

Rottenburg im Nationalsozialismus. Von der Machtergreifung bis zum Kriegsbeginn 1933 – 1939. Begleitband zum Ausstellungsprojekt von Stadtarchiv und Diözesanarchiv Rottenburg am Neckar. (Der Sülchgau, Band 52/53). Herausgegeben unter der Schriftleitung von Karlheinz Geppert vom Sülchgauer Altertumsverein Rottenburg am Neckar 2009. 286 Seiten mit zahlreichen Abbildungen. Broschiert € 19,90. ISBN 978-3-86595-332-2
Rezension von: Neusel, Wilhelm G. (Hrsg.), Kleine Burgen, große Villen
Authors: Schweizer Günther , Neusel Wilhelm G.
Published: June 2022

Kleine Burgen, große Villen – Tübinger Verbindungshäuser im Porträt. Herausgegeben von Wilhelm G. Neusel für den ArbeitsKreis Tübinger Verbindungen (AKTV). Tübingen: Selbstverlag des AKTV 2009. 276 Seiten mit zahlreichen, meist farbigen Abbildungen. Gebunden € 59,80. ISBN 978-3-924123-70-3
Rezension von: Meyer, Jürgen, Rittersitze, Festungen, Felsennester
Authors: Gerber Helmut , Meyer Jürgen
Published: June 2022

Jürgen Meyer: Rittersitze, Festungen, Felsennester in der Region Alb-Donau. Geschichte erleben und genießen. Oertel & Spörer Verlag Reutlingen 2011. 96 Seiten mit zahlreichen Abbildungen. Broschiert € 9.90. ISBN 978-3-88627-469-7
Rezension von: Frust, Manfred; Huth, Silvia; Sandbiller, Peter, Not macht erfinderisch
Authors: Waibel Raimund , Frust Manfred , Huth Silvia , Sandbiller Peter
Published: June 2022

Manfred Frust, Silvia Huth und Peter Sandbiller Not macht erfinderisch. Ein Jahrtausend Arbeit im Schwarzwald. Ein Ausflugsführer. Silberburg Verlag Tübingen 2010. 206 Seiten mit vielen farbigen Abbildungen. Kartoniert € 19,90. ISBN 978-3-87407-894-8
Rezension von: Steuer, Matthias, Ihro fürstliche Gnaden ...
Authors: Wrobbel Sibylle , Steuer Matthias
Published: June 2022

Matthias Steuer: Ihro fürstliche Gnaden ... Die Fürstpröpste von Ellwangen und ihre Kultur. Herausgegeben vom Geschichts- und Altertumsverein Ellwangen und vom Tourismusverein Ellwangen 2011. 355 Seiten mit zahlreichen, meist farbigen Abbildungen. Gebunden € 29,80. ISBN 978-3-00-024630-2
Tinjauan Maqāșid Al-Sharī’ah Terhadap Dispensasi Nikah
Authors: Mahfudz Lauhul
Published: June 2022

The age limit for marriage contained in the Marriage Law Number 1 of 1974 which is also mentioned in the Compilation of Islamic Law is the result of ijtihad, although in classical literature it is not found. The age limit itself is an attempt to avoid damage. On the other hand, the law provides leeway for prospective brides who are still under the age limit to request dispensation through the Religious Courts. In this regard, of course, judges are required to decide wisely without violating the Shari'a. This research is focused on Maqāșid al-Sharī'ah's review of marriage dispensation. With the emphasis of this study, this study uses the Maqāșid al-Sharī'ah approach. Meanwhile, according to the emphasis of the study, this research is classified as a normative rule research. Meanwhile, if observed according to the data collection operations studied, it is included in the category of library research (library study). Considering that this research belongs to the category of normative rule research in the form of library research, the research framework is classified as qualitative using a flow of thought and an inductive-deductive work pattern. The results of the study indicate that the dispensation in its implementation is divided into three, first; prospective partner who is not old enough and has never had sex, second; the potential partner is under the legal age, has had sex, but is not pregnant. both according to the perspective of Maqāșid al-Sharī'ah are not allowed to give permission for dispensation, and the third, namely the prospective partner who has not reached the age, has had sex and is pregnant, according to the perspective of Maqāșid al-Sharī'ah it is better to give permission for kawi dispensation.
Inconsistency Norm Peraturan Perkawinan Beda Agama (Studi Undang-Undang No. 1 Tahun 1974 Tentang Perkawinan Dan Undang-Undang No. 23 Tahun 2006 Tentang Administrasi Kependudukan)
Authors: Dewi Dwi Ratna Cinthya
Published: June 2022

The rules of marriage of different religions that have not been clearly and clearly defined in Law no. 1 Of 1974 concerning marriage. But article 35 letter a in Law no. 23 of 2006 concerning Population Administration provides an opportunity for marriage of different religions. Inkonsistensi this resulted in a conflict of norms. Therefore Lawrence M. Freidman's view is used as an analysis of the legal system in Indonesia. Research conducted to analyze inconsistencies between Law no. 1 of 1974 concerning Marriage with Law no. 23 of 2006 concerning Population Administration and Implications of inconsistencies concerning the regulation of marriage of different religions from legal system theory perspective Lawrence M. Freidman. This research is normative law, using the legislation approach and conceptual approach. Consist of primary law: Law no. 1 Of 1974 Concerning Marriage, Law no. 23 of 2006 Concerning Population Administration, legal system theory Lawrence M. Freidman. Legal material is obtained through documentation method. Then the legal material is analyzed by using qualitative descriptive analysis with related legal system as the theory. Result of research 1. The inconsistence of law due to the mismatch of legislation and the unregulation of marriage regulations of different religions clearly lead to legal uncertainty 2. The implication of inconsistency of marriage rules of different religions according to Lawrence M. Freidman's theory, has not yet achieved the good legal system in Indonesia.
Tinjauan Hukum Waris Islam Dalam Penundaan Pembagian Harta Warisan
Authors: Tilarsono Bambang Edi , Yaqin Husnul , Amri Amri
Published: June 2022

The provisions regarding inheritance in Islam are one of the provisions that have been described clearly and in detail, even Allah SWT ordered them to immediately implement them. This research aims to find out aspects of the trigger for inheritance not being distributed immediately and the views of Islamic law regarding the behavior of the East Koya people who do not immediately give inheritance to those who are entitled to receive it. This field research is sociological research of Islamic law. Information was collected using interview, observation, and documentation methods. After the information is collected, it is analyzed using data collection methods, data reduction, data presentation and conclusions, and analyzed using Islamic Law analysis. The results of this research are: First, the factors that delay the distribution of inheritance are: (a) the lack of deliberation between the heirs, (b) one of the parents is still alive, (c) the child is considered unable to carry out the inheritance, (d) the inheritance managed together, and (e) the lack of knowledge about the jurisprudence of the Mawaris. Second, the law delaying the distribution of inheritance by the Koya Timur community after fulfilling the rights of the deceased is unlawful or not justified by Islamic Shari'ah. This is because the instructions are clear both in the Qur'an and the Hadith of the Prophet SAW and in Article 175 of the Compilation of Islamic Law to immediately give inheritance to anyone who is entitled to receive it. In the rules of ushul fiqh it is also explained that the origin of the command is obligatory, so when someone does not carry out the obligatory command, it will be a sin.
Tinjauan Hukum Ekonomi Syariah Terhadap Pembiayaan Qarḍ Dengan Akad Mudārabah Di BMT NU Kalitidu Kabupaten Bojonegoro
Authors: Ash Shiddiqi Hasbi , Muslimah Siti
Published: June 2022

There are several customers who apply for financing at BMT NU Kalitidu for reasons of meeting their consumptive needs and paying debts, actually the contract that must be used is a qarḍ contract, but because there is no qarḍ product at BMT NU Kalitidu, a mudārabah contract was chosen, which facilitates the collaboration process because they are accustomed to using Mudārabah financing in entering into an agreement. Two things that become problems are first, How is the practice of qarḍ financing with a mudārabah contract at BMT NU Kalitidu, and How is the Sharia Economic Law Review of the practice of qarḍ financing with a mudārabah contract at BMT NU Kalitidu. This research is a field research with the place of research at BMT NU Kalitidu. The data sources include primary data, namely observations and interviews, while secondary data is obtained from reference data sources such as books, journals, articles and others. The method of collecting data in this research is from observation, interviews, and documentation, while the method used to analyze the data is a qualitative. The results of the study are: First, qarḍ financing does not exist in BMT NU Kalitidu, then the need for funds for a consumptive item in BMT NU Kalitidu is the same as mudārabah financing. The provision of funds for consumptive needs with a mudārabah contract is inappropriate (not allowed) because the use of a mudārabah contract must be accompanied by work carried out by the customer with funds from BMT NU Kalitidu.
Peran Pengadilan Agama Sentani Dalam Menangani Kasus Perceraian Pada Masa Pandemi Covid-19
Authors: Rini Yulia Sulistiyo , Wahib Moh , Kurniawati Laili Shofiya
Published: June 2022

The Covid-19 pandemic that is prone to household problems to divorce. The reality is that divorce has an impact on the Sentani Religious Court. Therefore, the researchers raised and answered the problem related to the factors causing divorce and the procedure for handling divorce cases at the Sentani Religious Court during the pandemic, as well the role of the Sentani Religious Court in handling divorce cases during the Covid-19 pandemic. This research uses qualitative methods with this type of field research and a normative juridical approach. Research location in the Sentani Religious Court, with data sourced from primary and secondary data. Researcher processing data by collecting, checking, and compiling data. Next, the researcher analyzes by summarizing and presenting the data in the form of a narrative to conclude. Test the validity of the data by triangulating and use reference materials.The results of this study were the factors causing divorce at the Sentani Religious Court during the Covid-19 pandemic, namely the Covid-19 pandemic that affected the family economy, one party left the house for no reason, the husband gambled and got drunk, domestic violence, and infidelity. The procedures for handling divorce cases during the Covid-19 pandemic are the usual litigation procedures from registration, trial to decisions with health protocols, and electronic litigation procedures (e-Court) from online case registration (e-Filing), online down payments (e-Payment), online summons of parties (e-Summons), and online trial (e-Litigation). The role of Sentani Religious Court in handling divorce during the Covid-19 pandemic is the application of health protocols in the Court environment, the use of electronic litigation applications (e-Court) where there was a lack of understanding of the parties regarding the technology and the occurrence of zero cases in May and December 2020.
LA LIBERALISATION DES PRIX ET PROTECTION DE CONSOMMATEUR EN DROIT CONGOLAIS
Authors: François KAPUNGA MWARABU , Pascal WITANNE MWANZO
Published: June 2022

L’activité économique joue un rôle capital  dans la vie des hommes en sciences étant donné qu’elle touche presque à chaque pas leur vie.

En effet, cette activité parvient à poser les problèmes de façon à permettre à ce que se coordonnent les projets économiques des hommes car la vie en société implique et suppose l’interdépendance économique des individus et de leurs actions. Et les échanges des biens et services passent nécessairement par l’activité économique qu’exercent les acteurs de ce domaine à savoir les commerçants  ou les opérateurs économiques.

Cependant, il faut une saine règlementation de l’activité économique dans la société, cela permettra de manière préventive  d’éviter tout dérapage  de la part des opérateurs économiques dans la fixation par exemple des prix des biens (produits) et services.

Le prix qui se définit comme étant une somme d’argent due par l’acquéreur d’un bien au vendeur  ou comme tout dû en échange d’un service est, selon le régime social ou politique en vigueur au sein d’un Etat donné, soit autoritaire, soit libéral.  Autrement dit, la fixation de celui-ci est l’œuvre de l’autorité publique, soit encore l’ouvre des opérateurs économiques  à travers  une politique de fixation libérale  des prix.