bluuebunny/crossref_metadata_2025 huggingface dataset:
Letter to the Editor – Update from Ukraine: Project Results in Oncology Telerehabilitation Approved at the National Cancer Institute and Showcased at the 4th National PM&R Congress
Authors: Malakhov Kyrylo S.
Published: January 2025

Telerehabilitation has emerged as a vital component of oncology care, particularly under challenging conditions where access to healthcare services may be restricted. This Letter to the Editor provides an update from Ukraine on a pioneering hybrid cloud-based platform designed for the patient-centered telerehabilitation of oncology patients. We summarize the project’s main outcomes, including the development of advanced AI-driven models, comprehensive methodological guidelines, and specialized software services. Notably, the platform underwent clinical approbation at the nonprofit organization “National Cancer Institute,” where its capacity for continuous patient monitoring, real-time data integration, and personalized rehabilitation interventions was demonstrated. Furthermore, the efficacy and innovation of this platform were showcased at the 4th National Congress of Physical and Rehabilitation Medicine in Ukraine, highlighting its potential to optimize resource allocation and improve patient outcomes. By merging mathematical and AI-based methods, the project underscores the importance of interdisciplinary collaboration in developing robust telerehabilitation ecosystems. We hope that this update contributes to the dialogue on expanding and refining telerehabilitation solutions globally, particularly in the realm of oncology care.
Pathological alterations and molecular identification of Marek’s disease in chicken
Authors:   Department of Veterinary Pathology, College of Veterinary and Animal Sciences, Mannuthy, Thrissur-680651, Chauriya B. , Sajitha S. , Prasanna K. S. , Devi S.S. , Anoopraj R. , Divya C. , Priya P.M. , Udhayakumar C.
Published: January 2025

Marek’s Disease (MD) in chickens, caused by the oncogenic avian herpesvirus known as Marek’s Disease
Virus (MDV), poses significant challenges to the poultry industry. This study was aimed at the molecular detection
of MDV in afflicted chickens focussing on the gross and histopathological changes. The diagnosis was confirmed by
cytological analysis of touch impression smear of the visceral organs with tumour like lesions. Employing polymerase
chain reaction (PCR) technique, the presence of the virus was detected in various tissues. Pathological examination
revealed characteristic lesions such as lymphoproliferative tumours in various organs including the spleen, liver, kidney,
proventriculus, heart and ovary. On microscopic examination, visceral organs revealed densely populated parenchyma
with infiltration of pleomorphic lymphoid cells. Out of 70 samples, 17 cases tested positive for MD. The findings provide
valuable insights into the occurrence, pathology and diagnosis of MD in chickens, contributing to better disease
management strategies and control measures of this economically important poultry disease.
Keywords: Marek`s disease, cytology, lymphocytes, methyl green-pyronine
EXPLORING THE PLIGHT OF THE HONEYBEE: USING DATA SENSORS AND CODAP TO SUPPORT EMERGING BILINGUAL LEARNERS IN REASONING ABOUT BIG STATISTICAL IDEAS
Authors: LEAVY AISLING , HOURIGAN MAIREAD , FITZPATRICK MICHELLE
Published: January 2025

Children require access to high-quality statistics education to develop the skills to participate in a technological and data-reliant workforce. This study consisted of a five-lesson integrated STEM unit designed to develop the statistical literacy of 62 6th-grade (11–12 years old) emerging bilingual (EB) learners. Learning was situated in the study of the honeybee, utilising innovative technologies to gather data and support data visualisation and analysis. Lesson study was used to design lessons targeting understandings of distribution, centre, variability, data comparison, informal measures of association and informal inference. This paper reports on the data comparison lesson. It reveals the influential role of digital technologies in highlighting the relevance of statistics in understanding societal issues and developing students’ statistical agency. This qualitative study also revealed that the development of statistical understanding was supported by the use of inclusive pedagogies guided by the principles of universal design and the incorporation of data analysis technologies.
Major Depresyonda Bilişsel Davranışçı Terapi: Bir Olgu Sunumu
Authors: Başeğmez Öyküm
Published: January 2025

This article presents a case study on the treatment of major depression with cognitive behavioral therapy (CBT). The article examines the case of a 30-year-old male client who received a diagnosis of major depression and subsequently underwent a 12-session course of cognitive behavioral therapy. The article discusses the client's history, core beliefs, negative automatic thoughts, symptoms, and progress during therapy. In conclusion, cognitive behavioral therapy is noted as an effective option for the treatment of major depression, and this article is highlighted as an important example supporting the use of this therapy method.
Keywords: Major Depression, Cognitive-Behavioral Therapy
Ebu Bekir El-Bakillani’ye Göre İ‘cazü‘l-Kur‘an
Authors: Mustafaoğlu Muhammed
Published: January 2025

Qadi Abu Bakr al-Baqillani (d. 403 AH/1013 AD) is considered the first person to write an independent work on the subject of i‘jāz. Those written before him were generally aimed at explaining the meanings of i‘jāz within the framework of general letters, introductions to works or explanations.
In this context, Bakillani was one of those who laid the foundations of this science with his work called I‘jazu’l-Qur’an. At the beginning of his work, he addressed the concept of miracle and determined that the Quran was the greatest miracle of the Prophet (peace and blessings of Allah be upon him). However, he stated that there were other miracles; however, he stated that the miraculousness of the Quran was a miracle of defiance. He stated that the situation was different compared to other miracles.
Qadi Bakillani was known as one of the leading scholars of the period in which he lived and the greatest proof and hujjat of his time. Bakillani, who has many works, mainly aimed to defend the creed and the Ash‘ari school of thought. He adopted a style based on discussion and dialogue and attracted attention with his strong proofs and broad culture. He lived in a period when multi-faceted schools of thought were competing and wrote his work, I‘jazu’l-Qur’an, in an effort to protect the foundations of religion, defend the belief in monotheism and prove the truth of prophethood.
Bakillani argued that the Quran has a different ruling than the books sent down to other prophets, and stated that the Quran constitutes evidence with itself. He argued that other holy books can only prove themselves with external evidence, because their words do not have miraculous characteristics.
According to Bakillani, the miraculousness of the Quran is based on three basic elements:
1. It informs about the unseen.
2. The fact that the Prophet (peace and blessings of Allah be upon him) was illiterate.
3. The unique verse of the Quran.
Analisa Pengaruh Main Pressure Tank Cellar dalam Proses Discharge Semen di MV. Cepat
Authors: Hidayat Ihsan , Anwar Amthori , Noviarianto Noviarianto
Published: January 2025

Discharge activities on a cement vessel can’t be separated from the discharge pneumatic system, because the bulk cement contained in the cellar tank must be pressurized so that the cement turns into dust and can be unloaded into the land sillo. Failure of the pneumatic system will pose a risk of time delays and losses for the company because it can’t carry out load discharge activities. When the cement discharge activity takes place, there are many problems with the pneumatic system due to the decrease in wind pressure. The purpose of this study was to determine the factors, impacts and efforts made to analyze the effect of main pressure on the cellar tank in the cement discharge process to reduce the risk of delays in cement discharge activities. This study used descriptive qualitative method. Where is described and explained each problem with a detailed explanation. Data collection techniques with the method of observation, interviews with the chief officer and supported by the method of documentation. Damage to the pneumatic valve system causes reduced pressure in the cellar tank to be a factor in the decrease in main pressure. The impact of decreasing main pressure causes cement discharge activities to not be carried out optimally and can even hinder cement discharge activities. The conclusion obtained is that efforts need to be made to improve the skills of the crew on the operation of the pneumatic system and control, routines for the maintenance of the pneumatic system equipment according to the system maintenance plan.
Pengaruh Ketersediaan Produk Dan Word Of Mouth Terhadap Keputusan Pembelian Pada Konsumen CV. Alisa
Authors: Suryaniningsih Suryaniningsih , Nurlaeli Fenti , Yolanda Silvi Yulis
Published: January 2025

Purchase decisions are influenced by several factors, including product availability and word of mouth. This study aims to determine the effect of product availability and word of mouth on purchasing decisions on  consumers CV. Alisa.The population in this study are consumers of CV. Alisa and the sample used the slovin formula totaling 97 respondents. Data collection techniques using a questionnaire. The analytical tool used is descriptive analysis. Data processing was carried out using the SPSS Statics Version 26.0 computer software program. The results showed that partially product availability has a positive and significant effect on purchasing decisions while word of mouth has no significant effect on purchasing decisions. The results of the simultaneous analysis of product availability and word of mouth have no significant effect on purchasing decisions at CV. Alisa. Company suggestions to improve service so that consumers are more confident in buying products at CV.Alisa. and companies are expected to pay more attention to the intended marketing channels, so that they are in line with business characteristics.
PENGARUH GAYA HIDUP, CITA RASA DAN BRAND IMAGE TERHADAP KEPUTUSAN PEMBELIAN ULANG (Studi Pada Konsumen Kopi Sabin Banjarnegara)
Authors: Mega Yuni , Maesaroh Siti , Suryani Ratna
Published: January 2025

ABSTRACT
The problem in this study is that there are consumers who are not satisfied with the lifestyle, taste, and brand image provided by Kopi Sabin. The aim of this research is to determine the influence of lifestyle, taste and brand image on repurchase decisions among Kopi Sabin Banjarnegara consumers. This type of research is quantitative research. Data collection was carried out using a questionnaire, data obtained from a sample of the research population, namely 87 consumers. The sampling technique in this research used a purposive sampling method. Data analysis uses multiple linear regression. Quantitative analysis in research uses validity and reliability tests with Cronbach's Alpha. The classical assumption test includes normality test, heteroscedacity test and multicollinearity test. The results showed that partially lifestyle affects repurchase decisions, taste affects repurchase decisions while brand image has no significant effect on repurchase decisions. Simultaneously, lifestyle, taste and brand image have a significant influence on repurchase decisions, as evidenced by the coefficient of determination of 57.8%, the remaining 42.2% is influenced by other variables not included in this research. Suggestions for future researchers are that researchers should be able to develop research with other variables.
Breaking the Taboo: Addressing Menstrual Health Challenges in India
Authors: Jadhav Pratiksha , Hajare Ashok , Vatsa Madhuranjan , Sebastian Shiju , Unnisa Syeda , Paliwal Manisha
Published: January 2025

Although, menstrual hygiene is a topic as ancient as mankind, it has recently garnered attention because society is more willing to face its difficulties. Adolescents seldom talk about issues related to menstruation, menstruation disorders, menstrual cleanliness, and customs of their culture. There is little data on the hardships that teenage females bear from menstruation and their social norms. Adolescent health education must include information about menstruation. Menstrual behaviors are often greatly influenced by culture, awareness, and social condition. However, periods, behaviors, and problems are seldom included in health education programs for the younger girls in impoverished nations. International health organizations such as WHO and UNICEF have advised developing culturally responsive menstrual health management (MHM) as well as water, sanitation and hygiene (WASH) programs for the adolescent girls. Without an awareness of the preconceived notions and prejudices that teenage girls in poor nations currently have about menstruation, these programs cannot be implemented. The goal of this review from India was to record the myths that are currently in circulation concerning menstruation, menarche, and other understudied menstrual constraints. Our goal in conducting this review was to characterize and assess the effectiveness of menstruation education programs designed to provide early teenage girls the information and abilities they need to support menstrual health.
Assessment of the level and quality of life in the regions of Russia
Authors:   Lipetsk State Technical University, Savina A.M. , Bizin S.V. ,   Lipetsk State Technical University
Published: January 2025

Subject. Quality of life is an integral indicator characterized by strategic orientation. Goal. Assessment of the level and quality of life in the regions of Russia based on quantitative and qualitative indicators and rating. Method or methodology. In the course of the work, general scientific methods were used: comparison, analysis, synthesis, analogy, as well as rating. The results of the work. Strengths are the availability of real estate, the quality of higher and secondary education institutions. The main problems of Lipetsk are housing and communal services, low interest in cultural values, quality of medical care, and unfavorable environmental situation. Conclusion. The basis for strategically ensuring sustainable growth in the quality of life of the population of the city of Lipetsk is: providing jobs, income that guarantees an acceptable level of well-being, high quality medical care, and basic social services. In addition, quality of life implies the opportunity for all members of society to participate in making vital decisions for the city and the use of opportunities provided by social, economic and political freedoms.
On the issue of improving legal regulation and practice of functioning military liability in Russia
Authors:   Lipetsk State Technical University, Zavrina E.E. , Tsapalikov I.O. ,   Lipetsk State Technical University, Makurin P.S. ,   Lipetsk State Technical University
Published: January 2025

Subject. The article analyzes the difficulties faced by the Russian state when creating an army at the turn of the century. There is a positive leap in comparison with the Soviet army model that preceded it – the introduction of contract service, mobilization reserve, as well as the institute of alternative civil service (hereinafter – AGS). The goal. The main purpose is to review and analyze the legal regulation and practice of the functioning of military duty in Russia. Method or methodology. The research includes a general scientific dialectical approach, as well as methods of logical, systemic, comparative and structural-functional analysis. The results of the work. The main results of the study are that Russian military and political elites are trying to respond in a timely manner to the emergence of new global trends and introduce them to Russian realities in order to ensure high combat readiness of the Armed Forces of the state. Conclusions. As a result of the study, it is also noted that the current models require further improvement, including taking into account foreign experience, both in terms of public policy and specific legislative measures.
Abuse of the right to appeal to the court in civil cases
Authors:   Lipetsk State Technical University, Palchikova S.I. , Nesterova A.S. ,   Lipetsk State Technical University
Published: January 2025

Subject. This article studies the problem of abuse of the right to appeal to the court in civil cases. Goal. To analyze in detail the various aspects and boundaries of the subjective right, as well as the limits of its exercise in the framework of civil procedural law, also special attention is paid to the differentiation of the concepts of abuse of right in the substantive and procedural senses. Method or methodology. The research is based on the method of analyzing legal sources. The results of the work. The article covers the analysis of judicial practice, revealing the main trends and approaches of courts to prevent abuse of right. Conclusions. The problem of abuse of the right to appeal to the court in civil cases is extremely relevant. Of fundamental importance in this issue is the differentiation of the concept of abuse of right in the substantive and procedural senses, as it determines the approaches to the solution of emerging legal issues. As practice shows, courts strive to prevent any form of abuse of right, especially when it may lead to violation of the rights and legitimate interests of other persons or society as a whole. Thus, within the framework of civil procedure law, it is important to take into account not only the formal compliance of actions with the law, but also their impact on the legal order and fairness of the trial. A special role in this is played by the principles of good faith and reasonableness, which should be guiding for all participants in the process.
Current problems of regulation of evidence in the Arbitration Procedural Code of the Russian Federation
Authors:   Lipetsk State Technical University, Palchikova S.I. , Sorokina A.E. ,   Lipetsk State Technical University
Published: January 2025

Subject. The article discusses current problems of regulating the process of evidence in the domestic arbitration process. Goal. Analyze certain rules governing the institution of advance disclosure of evidence, identify problems with its formulation in the law, and suggest possible options for changing the legislation. Method or methodology. The study was conducted using the method of analyzing legislation and judicial practice. The results of the work. The article analyzes the legislation regulating the process of evidence within the arbitration process, and also examines the conclusions and recommendations of higher courts regarding the application of this legislation. Conclusions. The problem of the lack of specific definitions of certain terms within the framework of evidence and the process of disclosing evidence in the arbitration process is relevant for all participants in legal proceedings, as it can lead to significant abuse of their procedural rights by persons participating in the case, and therefore directly affect the outcome of the trial, In connection with this, options for changing some wording in the legislation are proposed.
Innovation processes in small enterprise: status and ways of improvement
Authors:   Lipetsk State Technical University, Kisova A.E. , Savina A.M. ,   Lipetsk State Technical University
Published: January 2025

Subject. In the modern economy, innovation is an important factor in the competitiveness of enterprises and regions. Changes occurring in a complex and unpredictable environment force companies to constantly develop different ways to achieve competitive advantages, one of which is innovation. Despite the many factors limiting the introduction of innovations in small businesses, their commercialization is necessary because it allows the company to develop, adapt to changes faster and more efficiently, penetrate new markets and thereby achieve competitive advantages. Goal. Assessing the quality of organizational changes carried out in small enterprises, developing measures to improve it. Method or methodology. To achieve the goal of the research, the work used general scientific methods for studying economic phenomena, methods of systemic, logical, economic and statistical analysis, a method of empirical observation based on the collection and analysis of statistical information about the results of a commercial enterprise. The results of the work. An assessment of innovative processes in the activities of a small enterprise made it possible to classify them according to various criteria: the transformations were planned and manageable; had a linear and functional focus, were produced in a timely manner, and their scale was local. The scale of the changes was spotty; according to the degree of adjustability - controlled; by subject of management – management management. The nature of the transformations is progressive, the period of time is short-term. The expected result is positive. Conclusion. Analysis of the degree of efficiency of innovation processes at the enterprise allowed us to identify certain problems in terms of organizing and servicing business processes. In order to increase the innovative potential of a commercial organization and accelerate its innovative processes, measures were proposed in the field of organizing a unified business process management system, the basis of which is the development of a strategic map of goals for a balanced scorecard system; as well as the development of a modified matrix for their ranking in terms of position and labor intensity.
Increasing the level and quality of life in the region on the example of the Lipetsk region
Authors:   Lipetsk State Technical University, Bizin S.V. , Biryukov P.V. ,   Lipetsk State Technical University
Published: January 2025

Subject. The article is devoted to the study of the impact of the ongoing socio-economic policy on improving the level and quality of life in the region on the example of the Lipetsk region. Goal. The main purpose of the study is to study the level and quality of life in the Lipetsk region, as well as ways to improve them. Method or methodology. The methods of work include the method of theoretical knowledge, in particular analysis - consideration of individual aspects, properties, components of an object from a detailed point of view, synthesis - the creation of a complete picture of the subject under study according to its individual characteristics. Methodological tools are presented mainly in the form of collection and analysis of secondary data of statistical information. The results of the work. The socio-economic content of the level and quality of life of the population was studied. An assessment is made of the level and quality of life of the population in the region and a complex is formulated to improve the system for managing the level and quality of life of the population in the region. Conclusions. Based on the analysis of the quality and standard of living of the population of the Lipetsk region, both favorable trends and indicators that need to be paid close attention were identified. Based on this, a complex has been formulated to improve the system for managing the level and quality of life of the population in the region: it is necessary to introduce a system of lean production in all regional and municipal authorities of the region, accountable institutions. It is necessary to initiate regional projects aimed at young people in the field of providing them with jobs, benefits for the purchase or rental of housing, as well as supporting programs aimed at a healthy lifestyle.
Features of the analysis of the financial condition of small enterprises
Authors:   Lipetsk State Technical University, Volokitina D.S. , Titova O.V. ,   Lipetsk State Technical University, Kozlova E.I. ,   Lipetsk State Technical University
Published: January 2025

Subject. The article considers approaches to the selection of basic indicators necessary for assessing the financial condition of small businesses. Goal. To consider the content of the category "financial condition of the organization" and to determine the features of the analysis of the financial condition of small businesses. Method or methodology. Review of scientific literature on the issues of assessing the financial condition of small businesses. Results of the work. The study established the debatable nature of the content of the category "financial condition of the organization", as well as the generally insufficient development of methods for assessing the financial condition of small businesses. Conclusions. The use of simplified financial statements, restrictions on obtaining loans and government support, small sales volumes and other features of the activities of small businesses that must be taken into account when analyzing their financial condition, make it difficult to use a universal methodology, form the need to choose a reasonable variety of quantitative and qualitative indicators.
Economic aspects in the fashion industry
Authors:   Lipetsk State Technical University, Yurova E.R. , Bordyugova Yu.A. ,   Lipetsk State Technical University, Kantaryuk E.A. ,   Lipetsk State Technical University
Published: January 2025

Subject. This article examines the design factors affecting the economy in the modern world, as well as the role and importance of design in business. Purpose. The main goal of the study is to prove that not a single created product in the modern world can do without design, using the example of the fashion industry. Appearance, materials used and many other parameters that form the image of a product in business can only reveal themselves with due attention to design. Methods. The research is based on the general scientific methodology implying the application of the system approach and the general scientific methods of inquiry. Results. Based on practical studies proving that the success of many enterprises is associated with design, the factors that have the greatest impact on them have been formulated:1. Design adds value to the product. 2. Design brings innovation. 3. Design plays a critical role in user experience. Conclusion. After conducting this study, it can be noted that only at first glance design seems of little significance for business and the economy as a whole. Today, with a competent approach, the return on it will be the most important factor for selling a product on the fashion industry market. After all, given the same technical characteristics, most people will choose something that will interest them visually and also evoke positive emotions.
Construction of a traceability system in the movement of municipal solid waste in the Russian Federation
Authors:   Lipetsk State Technical University, Chereshnev A.S. , Kozlova E.I. ,   Lipetsk State Technical University
Published: January 2025

Subject. The article is devoted to the processes of transition in the Russian Federation from traditional waste collection systems to new ones based on the use of digital technologies. Goal. To analyze the legal basis for the formation of traceability in the movement of municipal solid waste in the Russian Federation. Method or methodology. The research toolkit includes an analysis of waste collection, sorting and recycling systems operating in developed countries; consideration of a set of legal documents on waste management at various levels of government in the Russian Federation. The results of the work. There have been certain successes in the process of building a traceability system in the movement of municipal solid waste in the Russian Federation. Conclusions. The intensification of urbanization processes leads to a significant increase in the formation of municipal solid waste (MSW) and leads to the fact that traditional waste collection systems are becoming increasingly ineffective and expensive. More efficient waste management methods involve the use of digital technologies, that is, solid waste management using sensors, intelligent monitoring systems and mobile applications, and further implementation of closed-loop waste recycling.
High crowder concentration promotes oxygen transport function of hemoglobin S - carbon monoxide binding renders it insensitive to change in crowder concentration.
Authors: Adedayo A. Fodeke  , Rahman A. Bolarinwa
Published: January 2025

Changes in crowding conditions affect functionally important structural changes in proteins. To understand how such changes affect the function of human hemoglobin S (HbSS), the affinity of CysF9[93]β sulfhydryl group of oxy and carbonmonoxy derivatives of HbSS for 5,5’-dithiobis(2-nitrobezoate) (DTNB) were measured in buffer 5.8 < pH < 9.0 under different crowding conditions (0 – 100 g dm-3 Ficoll 70). The affinities of the two hemoglobin derivatives for DTNB decreased with increasing pH at a given crowder concentration. For oxyhemoglobin, the average instantaneous gradient of the curve resulting from the fit under each crowding condition increases with increasing crowder concentration. Presence of the crowder did not significantly affect DTNB affinity of carbonmonoxyhemoglobin. Below pH 6.7, the affinity of oxyhemoglobin for DTNB increases with increasing Ficoll 70 concentration. Conversely, above pH 6.7, the affinity of oxyHbSS for DTNB decreases with increasing Ficoll 70 concentration at a fixed pH. Crowder did not significantly affect the affinity of carbonmonoxyhemoglobin for DTNB under the pH conditions of the experiment. This insensitivity of COHbSS to presence of crowder was attributed to formation of fiber by COHbSS. Hemoglobin fiber should be insensitive to high crowder concentration. The non-responsiveness of the affinity of DTNB for COHbSS to change in activity of the medium indicates that carbon monoxide binding to the hemoglobin promotes sickling or aggregation of hemoglobin. These findings were rationalized on the basis of the greater physiological relevance of oxygen binding to hemoglobin compared to carbon monoxide binding.
‘Ensinando a pescar’ - a educação empreendedora desenvolvida nas organizações sem fins lucrativos para beneficiários de programas equitativos sociais brasileiros
Authors: Nunes Kennya Rodrigues , Moreira Rogério Magela
Published: January 2025

A atividade empreendedora no Terceiro Setor e os programas de transferência de renda para a educação empreendedora refletem um papel fundamental na transformação social, sendo elementos-chave para promover oportunidades e reduzir desigualdades. Assim, é caracterizado por sua capacidade de interagir de maneira complementar ao setor público, criando iniciativas que vão ao encontro das demandas sociais e ampliam o acesso a oportunidades. Os programas de transferência de renda para a educação empreendedora serviram como um mecanismo essencial para incentivar a inclusão social e a criação de oportunidades de negócios, reduzindo assim a dependência de assistencialismo e promovendo a autossuficiência e a participação ativa na economia. Esse estudo objetivou compreender como o Terceiro Setor, através de programas de transferência de renda, contribuiu para a promoção da educação empreendedora e o desenvolvimento sustentável em comunidades carentes. A problemática abordou a necessidade de criar métodos eficazes para incentivar o empreendedorismo e a autossuficiência nessas comunidades. A justificativa baseou-se na relevância de compreender a interação entre o Terceiro Setor e a transferência de renda para construir estratégias inclusivas e eficazes. A pesquisa utilizou uma abordagem exploratória bibliográfica e método dedutivo, com análise de estudos sobre empreendedorismo social e políticas públicas. Esse estudo verificou que esse espaço tem representado um espaço crucial para o desenvolvimento de ações voltadas ao bem comum, compreendendo organizações privadas sem fins lucrativos que desempenham atividades de cunho social e comunitário. Ao abordar programas de transferência de renda no contexto de educação empreendedora, observa-se a relevância dessas ações para o desenvolvimento de habilidades empreendedoras em comunidades carentes, proporcionando a essas populações os recursos necessários para alcançar a autonomia econômica.
Nagyszombat hajnalán
Authors: Somogyi Szilvia
Published: January 2025

Jelen tanulmány azt vizsgálja, hogy mi lett a sorsa a mohácsi csatavesztést követően a „középkori magyar zsinati táj” normaszövegének, a késő középkori esztergomi szinodális könyvnek. Ezeket a határozatokat a középkori Magyar Királyságban csaknem másfél évszázadig használták a hazai egyházmegyék. Milyen tünetei voltak a középkori szöveg elavulásának? Hogyan nyúltak hozzá a magyar főpapok e szöveghez a nagyszombati zsinat (1560) előtt? Azonnal elfeledték? Módosították? Hogyan állt szolgálatába a technikai újítás, azaz a nyomtatás ennek a zsinati tevékenységnek? Az 1526 és 1560 közötti, átmenetinek tekinthető korszak három történeti forrásának vizsgálatával a fenti kérdésekre keresem a választ. E három forrás a Váraljai Szaniszló szepesi prépost által 1545-ben tartott zsinat ordójának egy kora újkori másolata, a Bornemisza Pál nyitrai adminisztrátor által az 1494-es nyitrai egyházmegyei zsinati határozatok mellékleteként 1560-ban kinyomtatott annotációk, valamint a nagyszombati zsinatot megelőző 1559-es pozsonyi püspökgyűlés jegyzőkönyve. E források mindegyikre nem csak az átmeneti korszak zsinati tevékenységének értékelése szempontjából tartalmaz értékes adatokat, hanem éppúgy a középkori egyház korábbi történetét kutatók számára is számos, megfontolás tárgyát képező kérdést vet fel.
A monyorókeréki és monoszlói Erdődy család kegyúri tevékenysége a vépi uradalom példáján
Authors: Kovács Eszter Katalin
Published: January 2025

A monyorókeréki és monoszlói Erdődy család vépi ágának patronátusi tevékenysége több oldalról is megjelenik. Ennek a patronátusi tevékenységnek egy eddig feldolgozatlan oldalát, a család kegyúri tevékenységét szeretnénk felvázolni a vépi uradalom példáján keresztül. Azt vizsgáljuk, hogy miként érvényesültek a kegyúri jogok és kötelességek a domínium két plébániájában.A kegyúri tevékenység és kötelezettség mindig fontos helyet foglalt el az Erdődy család és a birtok életében. A források alapján a família ezeknek a „feladatuknak” az évszázadok során mindvégig eleget is tett.A szakirodalmi meghatározás szerint a kegyúr jogai három csoportba sorolhatóak: a tiszteletbeli, a hasznos és az egyéb jogok. A tanulmányban ezeket bemutatva, a vépi uradalomban előforduló példákkal szemléltetjük is őket.
Ének- és zeneoktatói személyzet a kolozsvári református teológiai fakultáson a 20. század első felében
Authors: Füstös Paul-Gabriel
Published: January 2025

A felekezeti ének- és zeneoktatás kérdésköre az oktatástörténet fontos részét képezi. Az erdélyi református tanintézményekben a muzikális nevelés hosszú és érdekes múlttal rendelkezik. Ennek feltárása a pedagógiai és didaktikai folyamatok illetve módszerek megértése mellett belátást enged az egykori liturgikai metódusba is. A protestáns lelkészképzés mindig is különös hangsúlyt fektetett az egyházi ének- és zeneoktatásra, amelyre többek között a hatékony misszió eszközeként tekintettek. Jelen tanulmány az erdélyi református lelkészképzés oktatástörténetének egy szegletébe kíván betekintést nyújtani, nevezetesen a Kolozsvári Református Teológiai Fakultáson folyó 20. század eleji ének- és zeneoktatásba, közelebbről pedig a szóbanforgó katedra tanárainak életébe és munkásságába. A kutatás elsősorban az intézmény évente kiadott értesítőiben fellelhető adatokra támaszkodik, emellett pedig igyekszik a témát részlegesen érintő, meglehetősen kevés egyéb szakirodalomra is reflektálni.
The Formation of a Language of Science: Vitalism in 18th-century Scotland
Authors: Zhang Xiaoxi
Published: January 2025

Vitalism was a scientific theory that prevailed in 18th-century Scotland. Due to the influence of Boerhaave and the teaching of native scholars, vitalism appeared in Scotland in the first half of the 18th century. Its prosperity was closely related to the personal activities of William Cullen and marked by the acceptance and use of vitalism by other new disciplines, especially chemistry. Due to the continuous progress of experiments and the update of experimental instruments, vitalism was gradually replaced by experimental conclusions. Analyzed by social network analysis, the influencing factors affecting the spread of vitalism in Scotland in the 18th century are obtained. Officially, the University of Edinburgh and the teacher-student relationship were the main influencing factors; unofficially, William Cullens influence was the main influencing factor. As a scientific theory, vitalism experienced a limited rise and fall process; as a language of science, vitalism was borrowed by literature and other disciplines and has an influence even in biology today.
Research on the Impact of Word Stress on the Vowel System of English
Authors: Yang Yilin
Published: January 2025

Word stress is a fundamental aspect of English pronunciation that significantly influences comprehension in spoken communication. Despite its importance, many Chinese English learners find it hard to master the nuanced patterns of stress that distinguish stressed from unstressed syllables, particularly regarding vowel production, a topic studied by few researchers. Therefore, this study aims to explore the impact of word stress on the vowel system of English through an experimental analysis. Twenty disyllabic words with one stressed and one unstressed syllable were analyzed. Using auditory analysis software, the production of stressed and unstressed vowels by both native and non-native speakers was recorded, analyzed and then compared. Results indicate that native speakers produce stressed vowels with greater intensity and duration than unstressed vowels, while non-native speakers show less distinct differences.
A Study on the Preservation and Inheritance of Guqin Culture in the Context of Its Historical Development
Authors: Yan Shining
Published: January 2025

Guqin has a history of more than 3,000 years. According to legend, it is one of the oldest harpsichord music in China and one of China's intangible cultural heritages. It is not only the favorite of literati, but also contains rich social and cultural values. However, now the influence of Guqin has been negligible and gradually faded out of People's daily life, so it is urgent to protect Guqin culture. This paper studies the historical background of Guqin and the comparison between the ancient and modern development of Guqin and puts forward some methods to promote the development of Guqin. This paper first introduces the historical development of Guqin, starting from the origin, a detailed analysis of the development of Guqin in the Han Dynasty, Tang Song Dynasty, Ming Dynasty. Finally, the comparison of ancient and modern Guqin conditions triggers thinking about the protection of Guqin. At last, this paper puts forward two methods that are beneficial to the development of Guqin and thinks that more propaganda should be done.
Application of CRISPR/Cas9 system in type 2 diabetes mellitus
Authors: Zhang Xinyue
Published: January 2025

With the development of the social economy, the quality of people's living standards has improved. The risk of Type 2 diabetes mellitus (T2DM) is greatly increased. CRISPR/Cas9 system can provide more accurate and effective treatment for T2DM. Nowadays, the CRISPR/Cas9 system is still in the scientific research stage in the field of treatment of T2DM, and still has many uncertainties. For example, the off-target problem, the lack of clinical trials and ethical issues. This paper mainly analyzes and summarizes the research of CRISPR/Cas9 system on the treatment of T2DM, so as to provide a more systematic reference for the treatment method for future research. However, this treatment method also has the problem of Off-target. Although CRISPR/Cas9 system has high accuracy, it still has the problem of off-target, which may lead to the accidental injury of normal genes, thus causing unpredictable consequences. Technical problems: Although CRISPR/Cas9 system is relatively simple, it still needs superb technology and complex conditions in actual operation, which increases the treatment cost and time, and the sequelae of later treatment is still unclear. Both need further research by researchers.
Research progress of CRISPR technology in plant abiotic stress
Authors: Xiang Minyu
Published: January 2025

In recent years, the agricultural sector has faced immense challenges due to prolonged droughts, excessive soil salinity, and extreme temperature fluctuations, which have collectively stunted crop growth and significantly reduced yields. Such environmental stressors not only impact agricultural productivity but also pose a substantial threat to global food security. To address these challenges, advancements in gene editing have introduced CRISPR (clusters of regularly interspaced short palindromic repeats) tools, with CRISPR-Cas9 emerging as a particularly powerful and widely adopted technology. This tool offers high precision, efficiency, and cost-effectiveness, enabling targeted genetic modifications that can enhance crop resilience and facilitate the development of superior varieties. This paper discusses the fundamental principles and unique characteristics of CRISPR-Cas9 technology, providing a comprehensive summary of its applications in strengthening crop resistance to various abiotic stresses, including drought, salinity, and extreme temperatures. Additionally, it addresses the technology's limitations, outlining the areas that require further refinement to optimize its agricultural impact and broaden its applicability.
Applications of CRISPR-Cas9 Technology in Editing Telomeres and Their Related Control Genes
Authors: Liu Tianye
Published: January 2025

CRISPR-Cas9, awarded the 2020 Nobel Prize in Chemistry for its discovery by Jennifer Doudna and Emmanuelle Charpentier, has revolutionized gene editing due to its versatility, precision, and efficiency. Unlike previous gene editing tools such as Zinc Finger Proteins (ZFP) and TALENs, CRISPR-Cas9 allows targeted editing of any DNA sequence with minimal off-target effects. This article explores the potential of CRISPR-Cas9 technology to edit telomeresprotective DNA structures at chromosome endsand related genes to address telomere-associated diseases and aging mechanisms. Telomeres, consisting of repetitive DNA sequences and associated proteins, are crucial in protecting chromosomes and regulating cellular aging, with their progressive shortening linked to cancer and other age-related diseases. This article mainly discusses the molecular mechanisms of telomere maintenance, the feasibility of using CRISPR-Cas9 for telomere length control, and its implications for cancer, stem cell research, and telomere-associated diseases. While promising, further research is needed to fully understand the roles of regulatory pathways and non-genetic factors in telomere dynamics.
Comprehensive Insights into Schizophrenia Causes Treatments and Prevention
Authors: Shu Connie
Published: January 2025

With the significant improvement in material life in recent years, people now focus more on the status and well-being of spiritual life. The discovery and diagnosis of schizophrenia, a severe mental disorder, thus came into the attention. Current studies have centered on the causes and associations, which are often combined with the symptoms of schizophrenia. As a consequence, scientists developed various treatments. Some scholars suggested control and prevention methods, but many of them remained uninformative and unimplemented on account of real factors. The study combines most of the available information and gives a general overview of schizophrenia as an influential mental disorder. The mechanism of certain genes or alleles inherited from ancestors or unpleasant grown-up environments that can affect the risk of getting schizophrenia is analyzed. Treatment approaches referring to pharmacologic, psychotherapeutic, and other commonly mentioned ones are included. Some prevention techniques that correlate with health literacy, governance participation and parental environment are advocated. The meaning of this review lies in proposing a summarized thesis for schizophrenia, investigating present methods and indicating the inadequacies. In consideration of the shortcomings in medical care and public health system, it is expected that future research can inquire into innovative treatments and public prevention strategies.
Therapeutic Interventions Targeting Circadian Rhythms
Authors: Zhang Rongyu
Published: January 2025

Occurring biologically in a 24-hour cycle, circadian rhythms affect important activities like metabolism, hormone production, and sleep-wake cycles. Many medical illnesses, including sleep problems, depression, and metabolic syndromes, have been linked to disruptions in circadian rhythms. This study reviews the therapeutic approaches that aim to realign disrupted circadian rhythms. Among the methods under discussion are light therapy, melatonin supplements, chronotherapy, and pharmaceutical treatments aiming at circadian paths. The review includes studies that assess the efficacy and utilization of these therapies in clinical settings. Results imply that these treatments show encouraging results in controlling circadian rhythm problems, especially for diseases like insomnia, seasonal affective disorder, and shift work schedule. Still, topics needing more study are patient response variability and the long-term efficacy of these therapies. The possibility of tailored therapy strategies to improve the efficacy of circadian rhythm therapies and reduce side effects is underlined in this study.
Research Progress in the Carpal Tunnel Syndrome (CTS)
Authors: Meng Qinglong
Published: January 2025

Carpal tunnel syndrome (CTS) is a common condition that causes pain, numbness, and weakness in the hand due to a pinched median nerve in the wrist. A higher percentage of women than men have carpal tunnel syndrome, which affects about 3.8% of the population. The diagnosis procedure includes the patient's medical history, physical examination, and electrodiagnostic testing, all of which are essential for assessing the nervous system's function and severity. Based on these assessments, CTS is classified as mild, moderate, or severe. Conservative treatment, including corticosteroids, wrist splints, and a range of physical therapy, is usually recommended for mild to moderate cases, while surgical treatment is reserved for severe cases. Endoscopic carpal tunnel release (ECTR) and open carpal tunnel release (OCTR) are surgical options. The purpose of this article is to explore risk factors, diagnostic approaches, and treatment approaches in order to provide better individualized care in clinical practice, and to make recommendations for future treatment improvements and research.
The Application of Game Theory-Interesting Phenomena Between Time Pressure and Risk in Chess
Authors: Wang Renyu
Published: January 2025

This essay explores the application of game theory in chess, focusing on the relationship between time pressure, risk, and draw probability. Game theory provides a framework for analyzing interactive decision-making processes, enabling players to understand opponents' strategies, predict moves, and formulate optimal responses. The study utilizes a dataset of 20,058 chess games to examine the impact of duration on risk behavior. The analysis reveals a nonlinear relationship between game length and draw probability, with a parabolic trend suggesting that the likelihood of a draw increases with game length up to approximately 60-70 minutes, where it peaks at around 4%-5%, and then gradually decreases for longer games. The regression model shows time pressure leads to about 10% more risk-taking, indicating a moderate fit. These findings underscore the importance of time management and risk assessment in chess, with implications for enhancing players' competitive edge and strategic planning skills in both chess and real-world decision-making scenarios