bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploring HR practitioner’s perspective on linking of employer branding and porter’s generic strategies: an alignment of business and HR strategy
Authors: Dixit Aparna Sameer
Published: July 2023

Purpose

The purpose of this study is to identify the impact of Michel Porter's generic business-level strategies adopted by the organisation on its employer branding strategy. Based on the expert’s opinion and insights, this study aims to determine the extent to which the employer branding strategy, its inherent significance, the requisite investment and the used tactics are influenced by the organisation's business strategy.

Design/methodology/approach

Considering a phenomenological research design, this study adopted semi-structured interviews as a means to gather qualitative data from a purposive sample comprising HR professionals. The collected data were subjected to thematic analysis, enabling the identification of recurring themes and patterns. Findings and conclusions were subsequently derived in accordance with the outcomes of the thematic analysis.

Findings

The study revealed that the significance, nature, challenges and ways of implementation of employer branding strategies vary depending on the type of business strategy adopted by the organisation. While organisations pursuing a differentiation strategy heavily invest in employer branding and placing considerable efforts into developing an appealing employee value proposition, companies pursuing cost leadership invest relatively less in employer branding by implementing cost-effective tactics. Companies implementing a focus strategy demonstrate a moderate level of investment in employer branding initiatives.

Research limitations/implications

The study is limited to IT, manufacturing and banking sectors only. Additionally, the sample of the study is limited.

Practical implications

Employer branding as a strategy has been widely explored in the recent past. Similarly, Michel Porters’ generic strategies have also been widely researched. However, the interconnection between these two levels of strategies presents novel perspectives for business strategists and HR professionals involved in the formulation and implementation of HR strategies. This linkage provides valuable insights that facilitate effective decision-making in relation to employer branding strategies, enabling organisations to prioritise their objectives more effectively.

Originality/value

The existing literature lacks research that investigates the connection between employer branding strategy and business strategy. Hence, this study represents a pioneering effort that aims to explore this unexplored linkage. Further, this research effort has also uncovered previously uninvestigated findings concerning the comparative analysis of employer branding strategies across different sectors while examining the connection between business strategy and employer branding strategy.
Output regeneration defense against membership inference attacks for protecting data privacy
Authors: Ding Yong , Huang Peixiong , Liang Hai , Yuan Fang , Wang Huiyong
Published: July 2023

Purpose

Recently, deep learning (DL) has been widely applied in various aspects of human endeavors. However, studies have shown that DL models may also be a primary cause of data leakage, which raises new data privacy concerns. Membership inference attacks (MIAs) are prominent threats to user privacy from DL model training data, as attackers investigate whether specific data samples exist in the training data of a target model. Therefore, the aim of this study is to develop a method for defending against MIAs and protecting data privacy.

Design/methodology/approach

One possible solution is to propose an MIA defense method that involves adjusting the model’s output by mapping the output to a distribution with equal probability density. This approach effectively preserves the accuracy of classification predictions while simultaneously preventing attackers from identifying the training data.

Findings

Experiments demonstrate that the proposed defense method is effective in reducing the classification accuracy of MIAs to below 50%. Because MIAs are viewed as a binary classification model, the proposed method effectively prevents privacy leakage and improves data privacy protection.

Research limitations/implications

The method is only designed to defend against MIA in black-box classification models.

Originality/value

The proposed MIA defense method is effective and has a low cost. Therefore, the method enables us to protect data privacy without incurring significant additional expenses.
Soft computing in business: exploring current research and outlining future research directions
Authors: Singh Surabhi , Singh Shiwangi , Koohang Alex , Sharma Anuj , Dhir Sanjay
Published: July 2023

Purpose

The primary aim of this study is to detail the use of soft computing techniques in business and management research. Its objectives are as follows: to conduct a comprehensive scientometric analysis of publications in the field of soft computing, to explore the evolution of keywords, to identify key research themes and latent topics and to map the intellectual structure of soft computing in the business literature.

Design/methodology/approach

This research offers a comprehensive overview of the field by synthesising 43 years (1980–2022) of soft computing research from the Scopus database. It employs descriptive analysis, topic modelling (TM) and scientometric analysis.

Findings

This study's co-citation analysis identifies three primary categories of research in the field: the components, the techniques and the benefits of soft computing. Additionally, this study identifies 16 key study themes in the soft computing literature using TM, including decision-making under uncertainty, multi-criteria decision-making (MCDM), the application of deep learning in object detection and fault diagnosis, circular economy and sustainable development and a few others.

Practical implications

This analysis offers a valuable understanding of soft computing for researchers and industry experts and highlights potential areas for future research.

Originality/value

This study uses scientific mapping and performance indicators to analyse a large corpus of 4,512 articles in the field of soft computing. It makes significant contributions to the intellectual and conceptual framework of soft computing research by providing a comprehensive overview of the literature on soft computing literature covering a period of four decades and identifying significant trends and topics to direct future research.
Recycling English town centres – from retail to healthcare: surveys, views and next steps
Authors: Wiejak-Roy Grazyna Aleksandra , Hunter Gavin
Published: July 2023

Purpose

Many town centres in England exhibit high retail property vacancies and require regeneration. Several alternatives for the replacement of town centre retail (TCR) have been suggested, one of which is healthcare. The healthcare sector in England is in distress, with the National Health Service (NHS) tackling extensive patient waiting lists, whilst operating from an ageing estate. This paper is an introductory study that uses seven carefully selected personalised surveys to raise academic awareness of the importance and potential of integrating healthcare into town centres and calls for large-scale research to establish the statistical validity of the reported observations.

Design/methodology/approach

This study is developed from an interpretative standpoint. Through semi-structured interviews with key stakeholders specific to retail-to-healthcare conversions, this study reports stakeholders' perspectives on opportunities and limitations for such conversions to give direction for large statistical research in the future.

Findings

All participants support the integration of healthcare into town centres and agreed that diagnostic services, mental health support and primary care services are appropriate for provision within town centres. The participants advocate large-scale change in town centres in England, with integrated healthcare co-located with complementary services to fit with wider regeneration plans. Participants prefer adaptation of existing buildings where technically feasible and emphasise the importance of obtaining the buy-in of other stakeholders whilst expressing concerns about the uncertainty of capital funding availability.

Originality/value

This is the first study to analyse the practice of retail-to-healthcare conversions in town centres. These are still rare in England and projects are complex. The market experience is limited, and thus, the literature is scarce. This study fills this void and provides a starting point for future quantitative research in this area and informs the new town-planning policies.
Financialization and growth nexus in the EU new member states (NMS): an ARDL bounds testing approach and Granger causality analysis
Authors: Ganic Mehmed
Published: July 2023

Purpose

This study aims to explore the short-run and long-run relationships and causality between economic growth and financialization in the new member states (NMS-11) and to provide some policy implications drawn from the empirical findings.

Design/methodology/approach

The autoregressive distributed lag (ARDL) bounds test approach to cointegration with the vector error correction model and the cumulative sum of squares (CUSUMQ) test for stability of functions is used between 1995q1 and 2021q4 to examine the existence of cointegration, relationships and causality between economic growth and financialization.

Findings

The findings of the ARDL bounds test demonstrate that the variables included in the models are bound together in the long run, as confirmed by the associated equilibrium correction. The estimated models indicate that the association between selected variables and economic growth is stronger and more statistically significant in the short run compared with the long run. Also, for NMS-11 understudied countries, short-run causality prevails over long-run causality. The changes in the level of financialization have a significant negative effect on the growth rates in the short run, which aligns with findings from previous empirical studies.

Originality/value

This study extends the existing very limited literature about short-run and long-run relationships and causality among economic growth and financialization, including inflation and unemployment variables, to determine their link in the NMS-11. Specifically, the present study reveals that the current level of financialization hampers economic growth and promoting such economic policies further can have adverse effects on the overall economic growth.
Firms’ characteristics, corporate governance, and the adoption of sustainability reporting: evidence from Gulf Cooperation Council countries
Authors: Al-Qudah Anas Ali , Houcine Asma
Published: July 2023

Purpose

The purpose of the study is to investigate the factors that influence the adoption of new sustainability reporting (SDG) and external assurance (EXTA) practices. This study also examines the relationship between sustainability reporting activity and corporate economic performance for a sample of 99 companies in Gulf Cooperation Council (GCC) countries that addressed SDGs in their sustainability reports published in 2019.

Design/methodology/approach

Using a two-stage analysis, this study examines how firms’ characteristics and corporate governance variables affect SDG and economic performance, as well as the firm’s decision to adopt EXTA statements for a sample of companies in that addressed SDGs in their sustainability reports published in 2019. The authors collected data from the Global Reporting Initiative’s (GRI) Sustainability Disclosure database and the Bureau van Dijk for Orbis database.

Findings

The results show that the variables firm size, profitability, big 4 auditors and government ownership significantly affect SDG and economic performance. The results also reveal that firms operating in the manufacturing sector are positively correlated with SDG and the firm’s decision to adopt EXTA statements. Furthermore, the results indicate that board independence positively affects SDGs and EXTA.

Research limitations/implications

The results can be particularly relevant and timely in helping large GCC companies promote their engagement to sustainable development practices by adopting more sustainable long-term strategies and policies. The findings could also guide managers in the strategic direction to identify firms’ characteristics and corporate governance features essential to promote sustainability reporting, an increasingly important performance indicator for investors and to enhance their confidence in the capital market. The results may also have practical implications to policymakers and other regulators in GCC countries to define effective frameworks that promote sustainable development reports and the use of EXTA.

Originality/value

The results make significant contributions by providing new insights to the existing literature on sustainability reporting in emerging markets by examining a unique perspective on the influence of firms’ characteristics and corporate governance features on the adoption of new sustainability reporting practices. The authors further add to the previous literature on the relationship between a firm’s economic performance and sustainable reporting by providing evidence from large companies in GCC countries, which might benefit from the adoption of multiple conceptual lenses, in this case, legitimacy and stakeholder theories. Lastly, through the empirical findings, this study provides economic validity to the 2018 joint initiative of the GRI and the United Nations Global Compact to strengthen corporate actions to achieve the United Nations SDGs.
Re-routing development in peripheral regions: exploiting anchor institution networks for micro/SME enterprise growth and innovation
Authors: Downs Carolyn , Ryder Mike , Kalinowski T. Bartosz
Published: July 2023

Purpose

This study aims to explore the socio-cultural barriers to enterprise in economically disadvantaged communities across five countries: UK, Poland, Romania, Bulgaria and Greece.

Design/methodology/approach

This study’s EU-funded project took the form of community-based participatory action research. This study focusses on the data from the interviews and network mapping exercises. A total of 40 individual interviews took place, with interviewees from communities with entrenched disadvantage and limited opportunities for employment and education and low rates of business start-ups.

Findings

The research shows that barriers to entrepreneurship can be overcome where a trusted representative (or “mediator”) can act as a bridge, facilitating access to new knowledge and networks. This approach can be used to support micro/SMEs for growth and innovation. In targeting these businesses, policymakers need to recognise the power imbalances between actors and take steps to overcome these, by establishing links with community-based mediators who can act as trusted interlocutors, enabling sustainable relationships to be developed.

Originality/value

This research targets many often hard-to-reach groups and offers insights into the lived experiences of those who often operate at the peripheries. In doing so, it shows how trusted individuals can be used to remove barriers and promote growth, making clear links between theory to practice.
Reducing roadblocks to employee health care through benefit design implications and unintended consequences of utilization management in cancer treatment
Authors: Goldsmith Patricia J.
Published: July 2023

Purpose

HR leaders and corporate benefits managers must balance organizational costs with decisions about which new tools and treatments will be covered by their employee health insurance plans. Getting it right can mean the difference between life and death for cancer patients. Most HR leaders, however, are not experts in cancer treatment and do not know how to make sure their plan benefits do not create roadblocks to treatment.

Design/methodology/approach

A total of 295 people who were diagnosed with cancer from 2019 to 2022 participated in the 2023 CancerCare Biomarker Survey, which was conducted in January 2023.

Findings

CancerCare’s 2023 survey of cancer patients found that biomarker testing helped doctors tailor therapy for nearly all the patients (93%) whose cancers were tested over the past three years. Two in 10 cancer patients (20%) avoided unnecessary chemotherapy and/or radiation and one in 10 (10%) became eligible for a clinical trial because of biomarker testing.

Research limitations/implications

Biomarker testing is a necessary tool in the advancing world of precision cancer treatment. Despite the significant and demonstrable benefits to surveyed patients, three out of 10 respondents (29%) who received biomarker testing did not have the test covered by their insurance. Some survey respondents reported that biomarker test coverage was originally denied and they had to fight to get it covered. Others had to find ways to pay out-of-pocket or seek financial assistance to cover the cost of the testing.

Practical implications

Unfortunately, health insurance plans often limit cancer patients’ access to recommended biomarker testing, impose burdensome prior authorization (PA) protocols or require unaffordable cost-sharing, which can prevent or delay cancer patients’ access to optimal treatments. PA, a significant source of roadblocks to timely testing and treatment, was required by a quarter (25%) of the cancer patients surveyed.

Originality/value

Biomarker testing is increasingly a health care equity issue and there are significant gaps in the rate of biomarker testing between black and white lung and colorectal cancer patients, which can lead to disparities in clinical trial participation and hinder access to the most effective treatments. A key way to address these barriers is to broaden insurance coverage of biomarker testing, as recommended by medical experts.
Soil fungal communities contribute to the positive diversity–productivity relationship of tree communities under contrasting water availability
Authors: Fahey C. , Parker W. C. , Paquette A. , Messier C. , Antunes P. M.
Published: July 2023

Plant diversity has often been linked to increased productivity; however, this apparent diversity–productivity relationship may rely on intertrophic interactions such as those between plants and soil microbes. Soil fungi can create complementarity between plant species via altered plant resource partitioning, facilitation via fungal networks or biotic feedbacks, thereby promoting plant diversity–productivity relationships. Furthermore, these relationships are likely to be context dependent in response to resource availability.

We used a biodiversity–ecosystem function experiment with trees exposed to high and low water availability treatments to determine the contribution of soil fungal communities to the diversity–productivity relationship in tree communities. We used amplicon sequencing of soil fungi to assess fungal richness, community composition and richness of functional guilds. We then applied structural equation modelling to determine relationships between tree diversity, fungal communities and tree productivity and the role of water availability in these relationships.

Tree species richness and functional diversity both increased above‐ground tree productivity and influenced soil fungal community composition. Fungal community composition had a direct impact on tree productivity and enhanced net diversity effects on productivity. Therefore, fungal communities mediated a positive, indirect effect of tree richness on productivity. While total fungal richness was not associated with tree diversity, pathogen richness decreased and mycorrhizal richness increased with tree richness. Pathogen and mycorrhizal richness had either no impact or a weak negative effect on productivity. Tree species traits strongly affected fungal communities and these changes promoted productivity. Finally, water availability greatly influenced fungal communities but did not interact with tree diversity to affect productivity; indicating possible resilience of tree communities to altered precipitation regimes and associated changes in fungal communities.

Synthesis: Our study highlights the crucial role that fungal communities play in shaping the relationship between tree diversity, traits and productivity, and resilience to altered water availability.
Balancing the needs of the smaller twin against those of the larger one
Authors: Sarno Laura
Published: July 2023

Linked article: This is a mini commentary on Kalafat et al., pp. 191‐200 in this issue. To view this article visit https://doi.org/10.1111/1471‐0528.17564.
Opioid poisoning in Newcastle over the last three decades: From heroin to prescription opioids
Authors: Isoardi Katherine Z , Isbister Geoffrey K
Published: July 2023

Objective

Opioid‐related harm has risen in recent decades, but limited research describes the clinical burden of opioid poisoning to Australian EDs. We aimed to investigate hospital presentations with opioid poisoning over three decades.

Methods

This is an observational series of prospectively collected data investigating presentations of opioid poisoning to an ED in Newcastle (1990–2021). Type of opioid, naloxone administration, intubation, intensive care unit (ICU) admission, length of stay and death were extracted from the unit's database.

Results

There were 4492 presentations in 3574 patients (median age 36, 57.7% female), increasing from an average of 93 presentations annually in the first decade to 199 in the third decade. Deliberate self‐poisonings accounted for 3694 presentations (82.2%). Heroin dominated the 1990s, peaking in 1999 before decreasing. Prescription opioids then rose, with codeine (usually in paracetamol combination) predominating until 2018, after which oxycodone presentations exceeded them. Methadone consistently increased from six presentations annually in the first decade to 16 in the last decade. Naloxone was administered in 990 (22.0%) presentations and 266 (5.9%) were intubated, most frequently following methadone and heroin exposures. ICU admissions increased from 5% in 1990 to 16% in 2021. Codeine exposures resulted in less severe effects, whereas methadone had more severe effects overall. The median length of stay was 17 h (interquartile range 9–27 h). There were 28 deaths (0.6%).

Conclusion

Opioid presentations increased in number and severity over three decades as the type of opioid changed. Oxycodone is currently the main opioid of concern. Methadone poisoning was the most severe.
Weight loss and metabolic benefits of bariatric surgery in China: A multicenter study
Authors: Feng Wenhuan , Zhu Zhiming , Li Xiaoying , Zhou Zhiguang , Qu Shen , Sun Xitai , Zhu Dalong
Published: July 2023

Background

This retrospective multicenter study evaluated the efficacy and safety of bariatric surgery in Chinese patients with obesity.

Methods

Patients with obesity who underwent laparoscopic sleeve gastrectomy or laparoscopic Roux‐en‐Y gastric bypass and completed a 12‐month follow‐up between February 2011 and November 2019 were enrolled. Weight loss, glycemic and metabolic control, insulin resistance, cardiovascular risk, and surgery‐related complications at 12 months were analyzed.

Results

We enrolled 356 patients aged 34.3 ± 0.6 years with a mean body mass index of 39.4 ± 0.4 kg/m2. Successful weight loss occurred in 54.6%, 86.8%, and 92.7% of patients at 3, 6, and 12 months, respectively, with no difference in percent excess weight loss between the laparoscopic sleeve gastrectomy and laparoscopic Roux‐en‐Y gastric bypass surgery groups. The average percentage of total weight loss was 29.5% ± 0.6% at 12 months; 99.4%, 86.8%, and 43.5% of patients achieved at least 10%, 20%, and 30% weight loss, respectively, at 12 months. Significant improvements in metabolic indices, insulin resistance, and inflammation biomarkers were observed at 12 months.

Conclusions

Bariatric surgery resulted in successful weight loss and improved metabolic control, insulin resistance, and cardiovascular risk in Chinese patients with obesity. Both laparoscopic sleeve gastrectomy and laparoscopic Roux‐en‐Y gastric bypass are suitable approaches for such patients.
Dynamic changes in pathology andPD‐L1expression in a patient with metastatic lung adenocarcinoma who received pembrolizumab therapy followed by two salvage surgeries two years later: A case report
Authors: Hong Green , Park Hee Sun , Yeo Min Kyung , Lee Dahye , Chung Chaeuk
Published: July 2023

During chemotherapy, certain cancer cells undergo cell death, which alters the properties of remaining cells and leads to numerous changes in the constituent cells of lung cancer. Immunotherapy has been used as neoadjuvant therapy, and several studies have reported changes in lung cancer tissue following treatment with immuno‐anticancer drugs in early stage disease. However, no research has currently discussed the pathological and PD‐L1 expression changes in metastatic lung cancer. Here, we describe a patient with lung adenocarcinoma and multiple metastases who achieved complete remission after receiving initial carboplatin/pemetrexed followed by pembrolizumab treatment for 2‐years. The initial biopsy revealed adenocarcinoma with high PD‐L1 expression, and next‐generation sequencing (NGS) identifiedKRAS,RBM10, andSTAG2mutations. After 2‐years of treatment with pembrolizumab, the patient achieved complete response (CR). The patient underwent first salvage surgery for the oligo‐relapse lesion, and the pathology result showed a large cell neuroendocrine tumor (NET) with adenocarcinoma and no PD‐L1 expression. NGS revealedKRASandTP53mutations. After one year, a chest computed tomography (CT) scan revealed a small nodule in the right lower lobe, and the patient underwent second salvage surgery. Pathology results showed minimally invasive adenocarcinoma with no PD‐L1 expression and no significant genetic mutations. This case report demonstrates the dynamic changes cancer cells undergo following pembrolizumab treatment and salvage surgeries and is the first report to compare pathological changes after immunotherapy and two subsequent salvage surgeries in metastatic lung adenocarcinoma. Clinicians must remain vigilant to these dynamic changes throughout treatment and consider salvage surgery for oligo‐relapse lesions. By understanding these changes, new strategies can be developed to improve the long‐term efficacy of immunotherapy.
Assessing the potential for successful translocation and co‐management of two endangered aquatic species
Authors: Snowden S. K. , Shier D. M. , Stemp K. M. , Grether G. F.
Published: July 2023

Translocation programmes for endangered species typically focus on a single species, but in areas where little native habitat remains, it may be necessary to translocate multiple species to the same sites. Interactions between translocated species, such as predation and competition, are among the factors that need to be considered when planning multispecies translocations. Translocation sites for aquatic species are particularly scarce in southern California, where a limited number of sites exist for historically co‐occurring endangered mountain yellow‐legged frogs Rana muscosa and unarmoured three‐spine sticklebacks Gasterosteus aculeatus williamsoni. To determine how these species would interact if translocated to the same sites, we carried out experiments ex situ with R. muscosa tadpoles and a surrogate subspecies of stickleback (G. a. microcephalus). We found that (1) adult sticklebacks preyed on hatchling tadpoles but did not consume R. muscosa eggs or large tadpoles; (2) tadpoles did not consume stickleback eggs or disturb sticklebacks nests; and (3) both species' microhabitat use shifted slightly when the other was present. Our results suggest that these species can likely be co‐managed successfully, if measures are taken to curb stickleback predation on tadpoles until the R. muscosa population is well established. Using ex situ studies to evaluate species interactions prior to translocation is an approach that could prove useful in other species recovery programmes. Multispecies translocations could make better use of available resources when habitat is limited and promote ecosystem recovery by re‐establishing interactions among native species.
The excitatory transmission from basolateral nuclues of amygdala to nucleus accumbens shell regulates propofol self‐administration through AMPA receptors
Authors: Dong Zhanglei , Xiang Saiqiong , Pan Chi , Jiang Chenchen , Bao Suhao , Shangguan Wangning , Zeng Ruifeng , Li Jun , Lian Qingquan , Wu Binbin
Published: July 2023

Propofol addictive properties have been demonstrated in humans and rats. The glutamatergic transmission from basolateral nucleus of amygdala (BLA) to the nucleus accumbens (NAc) modulates reward‐seeking behaviour; especially, NAc shell (NAsh) is implicated in reward‐seeking response. Previous studies indicated the interactions between AMPA receptors (AMPARs) and dopamine D1 receptor (D1R) in NAc mediated drug addiction, but whether the circuit of BLA‐to‐NAsh and AMPARs regulate propofol addiction remains unclear. We trained adult male Sprague–Dawley rats for propofol self‐administration to examine the changes of action potentials (APs) and spontaneous excitatory postsynaptic currents (sEPSCs) in the NAsh. Thereafter, optogenetic stimulation with adeno‐associated viral vectors microinjections in BLA was used to explore the effect of BLA‐to‐NAsh on propofol self‐administration behaviour (1.7 mg/kg/injection). The pretreatment effects with NBQX (0.25–1.0 μg/0.3 μl/site) or vehicle in the NAsh on propofol self‐administration behaviour, the expressions of AMPARs subunits and D1R/ERK/CREB signalling pathway in the NAc were detected. The results showed that the number of APs, amplitude and frequency of sEPSCs were enhanced in propofol self‐administrated rats. Propofol self‐administration was inhibited in the NpHR3.0‐EYFP group, but in the ChR2‐EYFP group, there was a promoting effect, which could be weakened by NBQX pretreatment. NBQX pretreatment also significantly decreased the expressions of GluA2 subunit and D1R in the NAc but did not change the expressions of GluA1 and ERK/CREB signalling pathway. The evidence supports a vital role of BLA‐to‐NAsh circuit in regulating propofol self‐administration and suggests this central reward processing may function through the interaction between AMPARs and D1R in the NAsh.
Ultrasound examination of the pelvic floor during active labor: A longitudinal cohort study
Authors: Eggebø Torbjørn M. , Benediktsdottir Sigurlaug , Hjartardottir Hulda , Salvesen Kjell Å. , Volløyhaug Ingrid
Published: July 2023

Introduction

There is limited evidence about changes in the pelvic floor during active labor. We aimed to investigate changes in hiatal dimensions during the active first stage of labor and associations with fetal descent and head position.

Material and methods

We conducted a longitudinal, prospective cohort study at the National University Hospital of Iceland, from 2016 to 2018. Nulliparous women with spontaneous onset of labor, a single fetus in cephalic presentation, and gestational age ≥37 weeks were eligible. Fetal position was assessed with transabdominal ultrasound and fetal descent was measured with transperineal ultrasound. Three‐dimensional volumes were acquired from transperineal scanning at the start of the active phase of labor and in late first stage or early second stage. The largest transverse hiatal diameter was measured in the plane of minimal hiatal dimensions. The levator urethral gap was measured as the distance between the center of the urethra and the levator insertion using tomographic ultrasound imaging. Measurements of the levator urethral gap were made in the plane of minimal hiatal dimensions and 2.5 and 5 mm cranial to this.

Results

The final study population comprised 78 women. The mean transverse hiatal diameter increased 12.4% between the two examinations, from 39.4 ± 4.1 mm (±standard deviation) at the first examination to 44.3 ± 5.8 mm at the last examination (p < 0.01). We found a moderate correlation between the transverse hiatal diameter and fetal station at the last examination (r = 0.44, r2 = 0.19; p < 0.01; regression equation y = 2.71 + 0.014x), and a weak correlation between the change in transverse hiatal diameter and change in fetal station (r = 0.29; r2 = 0.08; p = 0.01; regression equation y = 0.24 + 0.012x). Levator urethral gap increased significantly in all three planes on both the left and right sides. Head position was not associated with hiatal measurements after adjusting for fetal station.

Conclusions

We found a significant, but only modest, increase of the hiatal dimensions during the first stage of labor. The risk of levator ani trauma will therefore be low during this stage. The change in transverse hiatal diameter was associated with fetal descent but not with head position.
Intrarenal pressures during flexible ureteroscopy: an insight into safer endourology
Authors: Hong Anne , Browne Cliodhna , Jack Greg , Bolton Damien
Published: July 2023

Objectives

To assess intrarenal pressures (IRPs) and complication rates after flexible ureteroscopy (fURS), and to assess factors that contribute to raised IRPs and postoperative complications.

Patients and Methods

After informed consent patients underwent fURS under general anaesthesia. The transducer of a 0.3556 mm (0.014″) pressure guidewire was placed in the renal pelvis for live recording of IRPs. The fURS procedures were performed in a routine manner under antibiotic cover with the aim of dusting the calculus to completion. The operating surgeon was blinded to the live‐recorded IRPs.

Results

A total of 40 fURS procedures were performed in 37 patients (26 male and 11 female). The mean age was 50.5 years. As a cohort, the mean of average IRPs was 34.8 mmHg and the mean of maximal IRPs was 128.8 mmHg. Pearson's correlation showed a significant inverse correlation between the mean IRP and age (r[38]: −0.391, P = 0.013). Three cases experienced postoperative deviations from uncomplicated recovery, with two being hypotensive and one case being both hypotensive and hypoxic. Three cases returned to the emergency department within 30 days of surgery, with two cases of flank pain and one case of urosepsis with positive urine cultures. The patient presenting with urosepsis had exhibited IRPs exceeding the mean.

Conclusion

The IRPs changed significantly from normal baseline levels during routine fURS. The mean IRP during fURS correlates with patient age, but not with other factors. The IRP may be related to increased complication rates at fURS. Understanding factors that influence IRP will allow urologists to better manage this intraoperatively.
Putting Complement Clauses into Context: Testing the Effects of Story Context, False‐Belief Understanding, and Syntactic form on Children's and Adults’ Comprehension and Production of Complement Clauses
Authors: Brandt Silke , Hargreaves Stephanie , Theakston Anna
Published: July 2023

A key factor that affects whether and at what age children can demonstrate an understanding of false belief and complement‐clause constructions is the type of task used (whether it is implicit/indirect or explicit/direct). In the current study, we investigate, in an implicit/indirect way, whether children understand that a story character's belief can be true or false, and whether this understanding affects children's choice of linguistic structure to describe the character's belief or to explain the character's belief‐based action. We also measured children's understanding of false belief in explicit false‐belief tasks. English‐ and German‐speaking young 4‐ and 5‐year‐olds as well as English‐ and German‐speaking adult controls heard complement‐clause constructions in a story context where the belief mentioned in the complement clause (e.g., “He thinks thatshe's not feeling well”) turned out to be false, true, or was left open. After hearing the test question (“Why does he not play with her?”), all age groups were most likely to repeat the whole complement‐clause construction when the belief turned out to be false. That is, they tended to explicitly refer to the character's perspective and say “He thinks…” When the belief turned out to be true, participants often reverted to a simple clause (“She's not feeling well”). Furthermore, children with better short‐term memory were more likely to repeat the whole complement‐clause construction. However, children's performance in explicit false‐belief tasks showed no relation to their performance in our novel, more implicit/indirect, task. Whether or not the complement clause was introduced by athatcomplementizer only had a small effect on the German adults’ responses, where leaving out the complementizer also changes the word order of the complement clause. Overall, our results suggest that task characteristics and individual differences in short‐term memory affect children's ability to demonstrate false‐belief understanding and to express this understanding linguistically.
Comparison of variants in TPMT and NUDT15 between sequencing and genotyping methods in a multistate pediatric institution
Authors: Cook Kelsey J. , Grusauskas Victoria , Gloe Lucy , Duong Benjamin Q. , Gresh Renee C. , Kolb E. Anders , Bansal Manisha , Bechtel Allison S. , Nagasubramanian Ramamoorthy , Kirwin Susan M. , Blake Kathryn V. , Seligson Nathan D.
Published: July 2023

The risk of severe adverse events related to thiopurine therapy can be reduced by personalizing dosing based on TPMT and NUDT15 genetic polymorphisms. However, the optimal genetic testing platform has not yet been established. In this study, we report on the TPMT and NUDT15 genotypes and phenotypes generated from 320 patients from a multicenter pediatric healthcare system using both Sanger sequencing and polymerase chain reaction genotyping (hereafter: genotyping) methods to determine the appropriateness of genotyping in our patient population. Sanger sequencing identified variant TPMT alleles including *3A (8, 3.2% of alleles), *3C (4, 1.6%), and *2 (1, 0.4%), and NUDT15 alleles including *2 (5, 3.6%) and *3 (1, 0.7%). For genotyped patients, variants identified in TPMT included *3A (12, 3.1%), *3C (4, 1%), *2 (2, 0.5%), and *8 (1, 0.25%), whereas NUDT15 included *4 (2, 1.9%) and *2 or *3 (1, 1%). Between Sanger sequencing and genotyping, no significant difference in allele, genotype, or phenotype frequency was identified for either TPMT or NUDT15. All patients who were tested using Sanger sequencing would have been accurately phenotyped for either TPMT (124/124), NUDT15 (69/69), or both genes (68/68) if they were assayed using the genotyping method. Considering 193 total TPMT and NUDT15 Sanger Sequencing tests reviewed, all tests would have resulted in an appropriate clinical recommendation if the test had instead been conducted using the comparison genotyping platforms. These results suggest that, in this study population, genotyping would be sufficient to provide accurate phenotype calls and clinical recommendations.
Patterns of species diversity in a network of artificial islands
Authors: Chimalakonda Deepthi , Chisholm Ryan A.
Published: July 2023

Aim

Artificial island habitats such as human‐made wetlands are emerging novel ecosystems. Understanding the drivers of diversity in such artificial systems is essential for balancing the goals of biodiversity conservation and human socio‐economic needs.

Location

Telangana state, India.

Methods

We surveyed water birds in a network of 57 artificial wetlands and assessed four macroecological biodiversity patterns: spatial betadiversity, temporal betadiversity, species‐abundance distributions (SADs), and the species–area relationship (SAR). We employed a mix of phenomenological and mechanistic models to examine the four macroecological patterns. We hypothesized that the wetland bird communities are primarily structured by immigration–extinction dynamics and thus that spatial and temporal betadiversity would be high, the within‐wetland SADs would exhibit a large number of rare species and a monotonically declining overall shape, and that the SAR across wetlands would be strongly increasing.

Results

Spatial and temporal betadiversity were both high and mostly attributable to turnover rather than nestedness. While the pooled SAD exhibited an interior mode, the SAD for individual wetlands was generally log‐series distributed, consistent with a model in which immigration among wetlands is high. The SAR exhibited an increasing trend, with the ‘small‐island effect’, which reflects constraints on immigration and is often observed for true island archipelagos, being absent.

Main Conclusions

We tentatively conclude that bird diversity in this network of artificial wetlands is mainly structured by immigration–extinction dynamics, although we acknowledge that some of the patterns are also consistent with niche dynamics and future research should measure relevant biotic and abiotic variables in these wetlands. We encourage future work in which our rich dataset is used to fit dynamic models that permit more‐detailed quantitative inferences about mechanisms structuring diversity in this novel ecosystem, which can ultimately also inform conservation management.
Artificial light at night has species‐specific effects on oviposition behavior of mosquitoes
Authors: Daufel Sabrina M. , Bohenek Jason R. , Sulliván S. Mažeika Patricio
Published: July 2023

Artificial light at night (ALAN) is a pervasive and growing issue worldwide. ALAN disrupts the physiology and natural crepuscular and nocturnal behavior of organisms, with widely observed effects on insects. Mosquitoes (Diptera: Culicidae) are disease vectors that evaluate and select freshwater habitats as oviposition sites. This behavior has both ecological and epidemiological implications. However, it is unknown how ALAN affects mosquito oviposition. We compared oviposition rates in outdoor mesocosms exposed to light‐emitting diodes (LED, 3000 K, ca. 13 lux) with dark controls. We assayed the oviposition behavior of natural populations of mosquitoes by quantifying mosquito eggs (Culex restuans Theobald and Ochlerotatus japonicus Theobald) deposited in the experimental mesocosms over 7 days. Mosquitoes had species‐specific responses to ALAN. Mean cumulative Cx. restuans egg raft deposition was greater in control pools than in ALAN pools (21 vs. 10 eggs). We observed no response of Oc. japonicus, potentially reflecting the risk associated with the alternative oviposition strategies of the two species (eggs rafts vs. skip oviposition). Our results show that ALAN has species‐specific effects on organisms, thereby complicating our understanding of the behavioral and potential ecological and epidemiological effects of this novel anthropogenic stressor.
The microbiota of Idaea inquinata developing on dry herbs
Authors: Magoga Giulia , Piombo Chiara , Locatelli Daria Patrizia , Limonta Lidia , Montagna Matteo
Published: July 2023

Idaea inquinata (Scopoli) (Lepidoptera: Geometridae, Idaeini) is a potential pest of stored food, mainly dry herbs. In this study, the role of diet in the shaping of the I. inquinata‐associated bacterial community was investigated and its impact on insect performance (i.e., proportion of adult emergence and duration of postembryonic development). Larvae were reared on three diets with different nutritional compositions: (1) Matricaria chamomilla L. flowers, (2) Angelica archangelica L. roots, and (3) artificial diet. A DNA metabarcoding approach targeting V1‐V2 and V4 regions of the bacterial 16S rRNA was adopted to characterize the bacterial communities associated with adults and larvae reared on different diets, and estimate their composition and diversity. The core microbiota of this species was found to include some bacterial genera commonly associated with Lepidoptera. When a coverage‐based integration of rarefaction and extrapolation of Hill numbers was used to compare groups of samples, the microbial diversity (estimated as phylogenetic diversity) differed among individuals reared on different diets, and also between larvae vs. adults. The lowest taxon diversity was found associated with individuals reared on M. chamomilla. Larvae fed with this fiber‐rich diet had also a significantly slower development. The composition of the microbial community varied among individuals with different diets, but not between adults vs. larvae. This study highlights the important role of diet in shaping I. inquinata microbiota, but also suggests that the microbiota of non‐feeding adult moths could be partially inherited from larvae.
Possible Batesian mimicry to sexually different models in the tussock moth Numenes albofascia with a great sexual color dimorphism
Authors: Yazaki Hidemori , Hayashi Fumio
Published: July 2023

Mimicry with warning colors includes Batesian and Müllerian mimicries. If we divide mimicry by sex, there are theoretically four types of mimicry: unimodal, female‐limited, male‐limited and dual mimicry. The latter three cases cause sexual dimorphism in body color and marking pattern but are rarely reported. In this study, we show that the tussock moth Numenes albofascia is possibly a dual mimic. The wing color and marking pattern of male and female N. albofascia are completely different, with the male's pattern resembling that of the smoky moth Pidorus atratus, while the female pattern resembles that of the tiger moth Arctia caja. Body size also differs greatly between the sexes of N. albofascia, matching the mimicry model species of each sex. These moths are distributed sympatrically in Japan, and their adult seasons overlap with each other. According to lizard feeding experiments, N. albofascia is palatable, while both male and female model species are unpalatable. Actograms in the laboratory and the light trapping in the field suggest that females of N. albofascia fly actively from sunset to midnight, while males fly during the twilight period around dawn. Therefore, male and female N. albofascia might be Batesian mimics of diurnally active P. atratus and nocturnally active A. caja, respectively, and the great sexual dimorphism of this moth could be caused by dual mimicry.
The paradox of cooperation among selfish cancer cells
Authors: Capp Jean‐Pascal , Thomas Frédéric , Marusyk Andriy , M. Dujon Antoine , Tissot Sophie , Gatenby Robert , Roche Benjamin , Ujvari Beata , DeGregori James , Brown Joel S. , Nedelcu Aurora M.
Published: July 2023

It is traditionally assumed that during cancer development, tumor cells abort their initially cooperative behavior (i.e., cheat) in favor of evolutionary strategies designed solely to enhance their own fitness (i.e., a “selfish” life style) at the expense of that of the multicellular organism. However, the growth and progress of solid tumors can also involve cooperation among these presumed selfish cells (which, by definition, should be noncooperative) and with stromal cells. The ultimate and proximate reasons behind this paradox are not fully understood. Here, in the light of current theories on the evolution of cooperation, we discuss the possible evolutionary mechanisms that could explain the apparent cooperative behaviors among selfish malignant cells. In addition to the most classical explanations for cooperation in cancer and in general (by‐product mutualism, kin selection, direct reciprocity, indirect reciprocity, network reciprocity, group selection), we propose the idea that “greenbeard” effects are relevant to explaining some cooperative behaviors in cancer. Also, we discuss the possibility that malignant cooperative cells express or co‐opt cooperative traits normally expressed by healthy cells. We provide examples where considerations of these processes could help understand tumorigenesis and metastasis and argue that this framework provides novel insights into cancer biology and potential strategies for cancer prevention and treatment.