bluuebunny/crossref_metadata_2025 huggingface dataset:
CÁC YẾU TỐ ẢNH HƯỞNG ĐẾN VIỆC TÍCH HỢP MÔ HÌNH THÔNG TIN THÀNH PHỐ (CIM) VÀ TRÍ TUỆ NHÂN TẠO (AI) TRONG QUẢN LÝ QUY HOẠCH ĐÔ THỊ
Authors: Nguyễn Hoài , Nguyễn Anh Thư , Đỗ Tiến Sỹ , Nguyễn Thanh Việt
Published: November 2023

Trong thời đại công nghệ số hóa hiện nay, có khá nhiều giải pháp công nghệ đang được áp dụng để nâng cao chất lượng quản lý quy hoạch đô thị, giúp cho việc xây dựng, phát triển và quản lý đô thị được hiệu quả hơn. Trong đó, công nghệ quản lý quy hoạch đô thị ứng dụng CIM (City Information Modeling) và AI (Artificial Intelligence) đang trở thành xu hướng mới trong lĩnh vực xây dựng. Nghiên cứu ứng dụng CIM và AI vào quản lý quy hoạch đô thị dự kiến sẽ mang lại nhiều lợi ích cho cộng đồng, giúp cho việc quản lý quy hoạch và phát triển đô thị được hiệu quả hơn, đồng thời cải thiện chất lượng sống của người dân trong thành phố. Bài báo này có mục tiêu xác định các nhân tố ảnh hưởng đến việc tích hợp mô hình thông tin thành phố (CIM) và trí tuệ nhân tạo (AI) trong quản lý quy hoạch đô thị. Dựa vào kết quả tổng quan nghiên cứu và góp ý của chuyên gia, nghiên cứu xác định được 32 nhân tố và 07 nhóm nhân tố ảnh hưởng đến việc tích hợp CIM và AI.
NGHIÊN CỨU CHẾ TẠO BÊ TÔNG HẠT MỊN CƯỜNG ĐỘ CHỊU NÉN TRÊN 100 MPa SỬ DỤNG XỈ THÉP CÔNG NGHIỆP LÀM CỐT LIỆU MỊN
Authors: Lê Huy Việt , Nguyễn Văn Khuây , Lê Ngọc Nam , Phạm Văn Khải , Trần Đình Tú , Tăng Văn Lâm
Published: November 2023

Cùng với sự phát triển của nền kinh tế, nhu cầu xây dựng các công trình nhà cao tầng và cơ sở hạ tầng có nhịp và quy mô lớn ngày càng cao, đi kèm với nó là yêu cầu về sử dụng các vật liệu cường độ cao. Bê tông cường độ cao đang được nghiên cứu ngày càng nhiều, tuy nhiên bê tông cường độ cao có cường độ chịu nén trên 100 MPa sử dụng xỉ thép làm cốt liệu mịn chưa được nghiên cứu ở Việt Nam. Trong nghiên cứu này, nhóm tác giả sử dụng hạt xỉ thép PS Ball, sản xuất theo công nghệ nguyên tử hóa xỉ - Slag Atomizing Technology (SAT) dạng hình cầu, đường kính trung bình 0.4 mm làm cốt liệu mịn thay thế một phần hoặc toàn bộ (0, 30, 50 và 100%) cát trong chế tạo bê tông cường độ cao. Xi măng PCB40 Bút Sơn và muội silic (SF90) được sử dụng làm chất kết dính. Hàm lượng nước trên xi măng được giữ ở tỷ lệ 0.2 kết hợp với phụ gia siêu dẻo để giảm lượng nước thừa cho thủy hóa nhưng vẫn đảm bảo độ lưu động của bê tông. Các điều kiện bảo dưỡng bao gồm nhiệt ẩm, ngâm trong nước và để ngoài không khí ở các độ tuổi khác nhau được đánh giá. Bên cạnh đó, ảnh hưởng của hàm lượng phụ gia khoáng hoạt tính silica fume (5, 15 và 25%) được nghiên cứu. Kết quả nghiên cứu đã chỉ ra rằng, khi hàm lượng xỉ thép thay thế cát tăng từ 0 đến 100%, độ chảy xòe của bê tông tăng 250 mm. Khi hàm lượng xỉ thép thay thế 50% cát và hàm lượng silica fume 25% ở điều kiện bảo dưỡng nhiệt ẩm 80oC trong 3 ngày, bê tông đạt cường độ chịu nén trung bình là 102 MPa.
A STUDY ON EFFECTIVE SAFETY MEASURE TOWORDS EMPLOYEE MOTIVATION AT ASHIRWAD PIPES LIMITED, ATTIBELE
Authors:   Department of management studies,  Sai vidya Institute of Technology, Rajanukunte, Bengaluru., kgu Sandeep , T C Chandana ,   Department of management studies,  Sai Vidya Institute of Technology, Rajanukunte, Bengaluru -560064
Published: November 2023

Employee motivation is a critical factor in achieving organizational success, productivity, and employee satisfaction. Ensuring a safe and secure working environment plays a pivotal role in boosting employee motivation. This abstract highlights the importance of implementing effective safety measures as a means to enhance employee motivation. It discusses the relationship between safety and motivation, detailing how safety measures can create a sense of well-being, trust, and job satisfaction among employees. The abstract also emphasizes the role of leadership and communication in fostering a culture of safety, which, in turn, positively influences employee motivation. By examining the connection between safety and motivation, organizations can develop strategies to create a workplace where employees are not only safe but also highly motivated and engaged, ultimately contributing to their overall success.
A REVIEW ON COMPUTATIONAL APPROACHES FOR IDENTIFYING NON-SYNONYMOUS MUTATION AND DNA METHYLATION IN CANCER
Authors: R.B Binisha , Natarajan Jeyakumar , Piramanayagam Shanmughavel
Published: November 2023

Cancer is a complex disease where, genetic and epigenetic changes plays a major role. Non- synonymous mutations and DNA methylation are important factors in cancer starts and development. Non- synonymous mutations are genetic changes that cause amino acid substitutions within proteins, which frequently result in defective or carcinogenic products. DNA methylation, on the other hand, is the addition of a methyl group to cytosine residues, which affects gene expression and contributes to cancer. Understanding the underlying mechanisms and designing targeted therapeutics require identifying these molecular events in cancer genomes. The traditional methods of identifying the mutations and DNA methylation has made a great challenge in the research fields. Computational approaches have shown to be important in this attempt. They cover a wide range of approaches, from mutation variant calling procedures to methylation pattern analysis tools. These methods will make use of high-throughput sequencing data to detect and characterize non- synonymous mutations and DNA methylation changes on a genome-wide scale. In this review, we will discuss about the multi omics dataset retrievals, tools used for the identification of mutated non- synonymous mutation and the algorithms and techniques used for DNA Methylation for identifying mutated regions. The critical values for the specific results also been noted in this study. Keywords: DNA Methylation, Non-synonymous genomic mutation, cancer, bioinformatics tools, algorithms
Impact of Social Media on Customer Behavior of Small Businesses in Hyderabad
Authors:   Department of Business Management, College of Commerce and Business Management, Osmania  University, Hyderabad, India, Alsebeaie Marwan Ali , Rao Prof. R. Nageswar ,   Department of Business Management, College of Commerce and Business Management, Osmania  University, Hyderabad, India
Published: November 2023

Customers turn to social media to find brands and make purchases from them. This study attempts to investigate the impact of social media on customer behavior using a quantitative approach to obtain a deep understanding of this phenomenon. An online questionnaire was distributed to the listed small businesses in Hyderabad, Telangana State, India via their emails. Data of self-administered questionnaire of small businesses for 197 participants were accomplished. Descriptive and inferential statistics are applied to the variables under study. Direct Connect, Trust, Customers' Satisfaction, Interaction, Customers' Value and Customers' Preferences are used as determinants of Customer Behavior in this study. Confirmatory Factor Analysis, Discriminant Validity and Hypothesis testing are used in the practical analysis to examine the impact of social media on the determinants of customer behavior. The results show that social media has a positive significant impact on the all involved variables (constructs) i.e., Direct Connect, Trust, Customers' Satisfaction, Interaction, Customers' Value and Customers' Preferences. Obviously, small businesses still have a need to gain more knowledge about how to engage social media into their marketing strategies. Key Words: Social Media, Customer Behavior, Small Businesses, Direct Connect, Trust, Customers' Satisfaction, Interaction, Customers' Value and Customers' Preferences.
REAL ESTATE PRICE PREDICTION USING MACHINE LEARNING
Authors: Chhiller Manudev , Shivam Shivam , Kumar Rishav
Published: November 2023

The real estate industry's notorious lack of transparency and volatile housing prices have spurred research projects to enhance housing price predictions. These initiatives employ a combination of regression techniques, emphasizing the weighted average of these methods to yield more accurate outcomes. They also suggest the utilization of real-time neighborhood data from Google Maps to enhance real-world valuations. With the real estate market's competitiveness and its reliance on factors like physical condition, concepts, and location, these projects strive to forecast residential prices based on customer financial needs, studying historical market trends and forthcoming developments. Multiple regression techniques such as Linear Regression, Lasso Regression, Forest Regression aiming to optimize house price predictions and assist lower- and middle-class individuals with financial parameter-based price estimations. Overall, these projects leverage data science and machine learning to address real estate pricing challenges, seeking to enhance transparency and decision-making for both buyers and investors. Key Words: Real Estate, Linear Regression, Lasso Regression, Forest Regression, Decision-making.
E-Mentoring System
Authors:   Assistant Professor, Department of Computer Engineering, MET’s Institute of Engineering, Nashik, Kale Mr. Ashutosh
Published: November 2023

Tutoring has long been a proven method of increasing mentee motivation and performance. However, traditional training methods can be replaced by using electronic training. This new system works on a client-server model and seamlessly connects mentors and mentees. It simplifies the process of accessing mentee information and provides mentors with easy access to important mentee information. The main purpose of this process is to provide mentors with a deeper understanding of the challenges mentees face, ultimately helping to improve mentee performance. It also has a ranking system that allows mentors to evaluate mentees’ academic performance and provide assistance to those in need. Key Words: Mentor, Mentee Management, Education, Career Development.
Non-Changeable Document using Blockchain
Authors:   Samarth Group of Institutions College of Engineering, Belhe, Maharashtra,, Gaikwad Rohan , Bhor Adesh , Bhor Yash , shelke Prof. Shubham
Published: November 2023

The concept of Non-Changeable Documents (NCDs) using blockchain technology is a pivotal development in ensuring data integrity and security. This paper explores the innovative approach of employing blockchain to create immutable records, guaranteeing the authenticity and integrity of documents. NCDs leverage the decentralization and cryptographic features of blockchain, rendering documents unalterable. Their application spans across various industries, including legal, healthcare, and finance, promising significant advantages in terms of fraud prevention, transparency, and compliance. This research paper also delves into the technical underpinnings of NCDs, elucidating the cryptographic mechanisms and consensus protocols that safeguard their reliability. By harnessing the decentralized and tamper-proof nature of blockchain, NCDs provide a formidable solution for organizations seeking to safeguard critical data against unauthorized alterations. This transformative potential of Non-Changeable Documents underscores their ability to elevate document security and establish trust in an increasingly interconnected digital landscape. In an era marked by data breaches and concerns over document authenticity, NCDs offer a promising avenue to ensure the integrity and security of sensitive information, reinforcing trust in digital records. Key Words: Blockchain, Documents, Fraud, Smart Contract, Ethereum Blockchain, Security
Making Solutions Visible: Facilitating Housing Equality through Interface Design
Authors: Kalodner-Martin Elena , Leon Kendall
Published: November 2023

Purpose:Drawing from research on the role of digital interfaces in sociopolitical change (Selfe & Selfe, 1994; Sano-Franchini, 2018; Hallinan et al., 2022), this article identifies how, in the wake of an ongoing public health crisis, one homelessness advocacy organization leveraged their website to reflect and facilitate a shift in priorities and practices. This article addresses two questions: • In what ways are organizational values emergent, mediated, and reimagined through interface design? • How can practitioners enact ethical design decisions in their work to 1) make solutions-oriented impact visible and 2) help users achieve action and social-justice oriented goals?Method:To answer these questions, we draw from an extended case study from Lex End Homelessness (LEH), a homelessness prevention and intervention initiative based out of Lexington, KY, USA. Since its launch, LEH has moved from dispelling harmful myths about homelessness to ideological conversations about homelessness causes and potential solutions (Kalodner-Martin, 2022). As a result, the website, given its public- facing nature, is being rebuilt to reflect LEH's transition.Results:Results demonstrate that the LEH's website interface reflected changes in the organizational priorities, the ideological context, and local needs, specifically regarding supporting understanding, emphasizing, and acting to end homelessness.Conclusion:As an ongoing project, we conclude our article outlining next steps in the interface redesign.
盾构机下穿某公共建筑物施工技术的研究
Authors:   成都轨道交通集团有限公司, 陈 凯
Published: November 2023

随着城市地铁建设的快速发展，盾构技术在地铁隧道施工中得到了广泛应用。然而，当盾构需要穿越下穿建筑物时，会面临许多挑战和风险。本文对盾构穿越下穿某公共建筑物的施工技术进行了分析，探讨了相关技术和管理方法，从危险源辨识、盾构穿越加固措施、盾构穿越掘进控制措施、掘进参数优化措施等方面进行优化，确保盾构机能顺利穿越某公共建筑物，为以后盾构穿越公共建筑物提供了可行的施工方案。
Microbial Biotransformation of Agro-waste Into Biovanillin as Flavor: A Process Optimization by Response Surface Methodology
Authors: Sujatha M. , Jaya Madhuri R. , Thagaraju K.
Published: November 2023

Vanillin is a flavour that is commonly employed in the food industry, but plant sources can yield a small amount of this molecule. Fermentative production of biovanillin by optimizing different process parameters such as specific pH, temperature, incubation time, carbon source, nitrogen source, ferulic acid substrate, and by agro wastes are beneficial in terms of fermentation economics and scale up of the process response surface methodology for an ideal production of biovanillin yield. Hence the present research emphasizes on optimization of fermentation conditions for employing Bacillus licheniformis MSJM5 isolate. As per the experimental results biovanillin production yield was enhanced at neutral pH, mesophilic temperature, in an incubation of 48 hrs, under revolving conditions, in the presence of glucose as carbon source soya bean as nitrogen source ferulic acid 0.3 mg concentration and ground nut oil cake, an agro waste material has stimulated the formation of biovanillin, 326-834 mg/ml. Further stastical analysis by RSM the yield of biovanillin was 1.89 mg/ml. Based on the morphological cultural and biochemical the positive strain MSJM5 is identified as Bacillus licheniformis with 98% homology and accession number ON413745. Strain improvement studies have reveated that UV light and Et Br use reduce the survival capacity of Bacillus licheniformis.
Aroma Chemicals Identification by Sophisticated Technique and Their Role Against Pathogens
Authors: Sekhar N. , Srimannarayana M. , Deepika N.
Published: November 2023

Citrus fruits and their essential oils play a vital role in every aspect of human life. Essential oils derived from citrus peel are rich in polyphenols and act as secondary metabolites to treat various diseases and they can be used as insecticide or pesticide. These citrus oil derivatives are much popular in flavour and fragrance industry and FMCG sector. In present research work five variants of citrus fruits; C. aurantium (Narinja), C. hystrix (Gondhoajlebu), C. limon (Lemon), C. limetta (Mosambi) and Citrus reticulata Blanco (Nagur Orange) were selected from different regions of India; Telangana, Andhra Pradesh, Kolkata and Maharashtra. The collected samples were further studied using SPME-GCMS analysis to identify the specific molecules which are not in common. Most identified moleculesthrough GCMS analysis are Limonene, Alpha pinene, Myrcene, Delta-carene, Sabinene etc. Each molecule has a significant aroma and used in many Flavour & Fragrance industry. The chemical molecules identified in Narinja (C. aurantium) citrus fruit are specific and not identified in any of the selected fruits they areBicyclogermacrene, Isopiperitenone, Alpha eudesmol, Beta eudesmol. Antimicrobial activity of five essential oilsreports Narinja oil has potent activity on E. coli, Staphylococcus aureus and Bacillus followed by lemon oil and orange oil on E. coli and Bacillus, Mosambion Bacillus and Gondhorajlebu on E. coli. This data reveals that there aresome specific molecules in C. aurantiumto be considered for further research for their medicinal aspects, as mosquito repellent or in F&F industry.
Parametrización y Personalización de un Sistema de Gestión Documental para los Semilleros de Investigación en la ETITC.
Authors:   Escuela Tecnológica Instituto Técnico Central, Hernández Ortiz Eduardo , Melo Luis Alfonso , Hernández Ortiz Eduardo
Published: November 2023

La gestión del conocimiento generado por necesidad para el ámbito académico de la desde el punto de vista tecnológico que semilleros de investigación cumpla con los semilleros de investigación propone una nueva ETITC. La presente investigación propone una solución permita que el conocimiento surgido al interior de los una serie de buenas prácticas que garanticen un potencial es necesario conocer como conservado y transmitirlo, ayudando al perfeccionamiento de las capacidades del mismo capital humano.
Autonomous Systems Functional Safety Overview with Multimodality and Explainability Perspectives
Authors: Tiako Pierre , Kamsu-Foguem Bernard
Published: November 2023

Functional safety is crucial in automation systems, particularly for autonomous vehicles. It is important because it protects humans, systems or vehicles, and operating environments from harm. Automated systems can expose operators to severe safety risks. Functional safety aims to minimize safety risks associated with autonomous systems to protect operators, the environment with nearby infrastructure and people, and the systems themselves. This paper overviews multiple facets of Artificial Intelligence (AI) techniques that reduce functional safety risks. As AI and Machine Learning (ML) progress theoretically and in their application, we face new technical challenges in dealing with Multimodality and Explainability. We will discuss these concepts before briefly providing their perspectives on minimizing safety risks in autonomous systems.
Automatic Test Generation for Microservices Based on Consumer-Driven Contracts
Authors: Zahedi Shaheen , Paydar Samad
Published: November 2023

Microservices offer a shorter time-to-market by improving productivity with maximizing the automation of the software development lifecycle. However, when dealing with such systems, there are important design principles like their solidness and test coverage, which should be considered to be able to co-operate well in a distributed environment especially from the architecture level. However, for the provider of a service, it might be challenging to maintain the obligations needed by the consumer. Therefore, in this approach a form of agreement is written by the consumer of the service, which is called contract. In this paper, a language agnostic, no-code approach is proposed for conducting the consumer-driven contract concept, through automatically converting the contracts into a set of solid test suites, that runs on each deployment. Consequently, if the service provider alters the returned data in a way that breaks the expectations of the consumer, this breaking change will be detected early by running the auto-generated test suites. The proposed approach also provides an insight for the provider, on how their service is being used and how changes can affect the consumers. Then it gets evaluated with a dataset of 56 open-source projects available on Github which use consumer-driven contract testing. The results demonstrate that for 56 real source projects, the proposed approach has been able to generate 450 tests from the contract files in the sources and 90% of the generated test suites passed.
Het gebruik van het zwijgrecht tijdens het politieverhoor: opvattingen en ervaringen van gedetineerden
Authors: Vanderhallen M. (Miet) , Sauerland M. (Melanie)
Published: November 2023

Het gebruik van het zwijgrecht tijdens het politieverhoor: opvattingen en ervaringen van gedetineerden

Het zwijgrecht is een fundamentele procedurele waarborg voor personen die van een misdrijf beschuldigd worden. Het recht is verbonden aan het recht om zichzelf niet te beschuldigen, namelijk het idee dat niemand gedwongen kan worden om aan de eigen veroordeling mee te werken. Interviews met professionals uit Nederland en België suggereren evenwel dat in de praktijk regelmatig conclusies worden getrokken uit het feit dat een verdachte van het zwijgrecht gebruikmaakt. Empirisch onderzoek naar deze materie focust zich doorgaans niet op het perspectief van de (zwijgende) verdachte. Deze bijdrage heeft tot doel om inzicht te verwerven in de beslissing van verdachten om het zwijgrecht in te roepen alsook hun ervaringen met de reacties en gevolgen daarvan.
Strafbaarstelling van seksuele deepfakes
Authors: Goudsmit Samaritter M.L.R. (Marthe) , Aksay R.F. (Ruben) , Oerlemans J.J. (Jan-Jaap)
Published: November 2023

Strafbaarstelling van seksuele deepfakes

Deepnudes zijn een toegankelijke vorm van seksueel misbruik met beeldmateriaal. Dit artikel behandelt de definitie van deepfakes en de achterliggende technologie alvorens de vraag te behandelen of het strafrecht een legitieme rol heeft bij aanpak van seksuele deepfakes. Geconcludeerd wordt dat pornografische deepfakes gerechtvaardigd strafbaar gesteld kunnen worden door hun schadelijkheid en onrechtmatigheid. Daarop volgt een analyse van bestaande strafwetsartikelen en hun geschiktheid voor aanpak van seksuele deepfakes. Het artikel wordt afgerond met een aanbeveling voor verbetering in strafwetgeving.
A Numerical Study on the Large Displacement in Functionally Graded Beam under Thermal Effect
Authors: DEMİR Ersin
Published: November 2023

The large displacement behavior of a Functionally Graded (FG) beam under uniform thermal load is investigated numerically. Six different effects are taken into consideration when examining the large displacement behavior of the beam. These are the effects of temperature, material, geometry, slenderness, force, and boundary condition. The nonlinear numerical analysis is carried out by using the Simulation mode of SolidWorks, which is a finite element-based commercial program. As a result, the displacement of the end of the beam increase with increasing temperature, slenderness ratio, and force. However, it decreases with increase in the ratio of ceramic in Functionally Graded Material (FGM) and the width of the beam. Moreover, as expected, the maximum and minimum displacements are obtained in the beams with Clamped-Free and Clamped-Clamped boundary conditions, respectively.
ETIKA GENERASI MILENIAL SEBAGAI PERWUJUDAN NILAI-NILAI PANCASILA
Authors: Muhammad Abyan Akbar
Published: November 2023

This study aims to provide an explanation and recommendations based on previous studies on the ethics of the millennial generation in the framework of realizing Pancasila. This research is a qualitative research using a literature review method from previous research and textbooks that are appropriate to the topic. The research data is in the form of primary and secondary data obtained by means of a literature review. Qualitative research data analysis uses the stages suggested by Miles & Hubberman (1992) consisting of data collection, data reduction, displaying the reduced data and drawing conclusions. The results of the study show that in general the millennial generation still has ethics in interacting with their environment, although there are several studies showing that the millennial generation is unethical in using social media
KESEJAHTERAAN PSIKOLOGIS PADA MAHASISWA RANTAU UNIVERSITAS SAHID SURAKARTA
Authors: Yopi Putri Ramadani  , Anniez Rachmawati  , Faqih Purnomosidi
Published: November 2023

Students who leave their home area to live for some time in another area are called overseas students. Becoming an overseas student is not an easy thing, apart from the dissatisfaction of a student, it often creates feelings of discomfort and unhappiness which results in poor psychological well-being for overseas students. This research was conducted with the aim of knowing the Psychological Well-being of Overseas Students at Sahid University, Surakarta. In this study using qualitative methods with observation and interview data collection techniques. The informants of this study were students from overseas outside Java who studied at Sahid University, Surakarta, totaling 7 informants. The results of this research are the psychological well-being of overseas students outside Java who study at Sahid University, Surakarta, in general 4 have good psychological well-being, 3 of them have poor psychological well-being, these 3 informants must be able to improve aspects of self-acceptance and aspects of development self.

 

Keywords: Psychological Well-being, Overseas Students
KONTROL DIRI TERHADAP PENGAMBILAN KEPUTUSAN KARIER SISWA
Authors: Ezra Addo Setiawan
Published: November 2023

This study aims to determine the level of self-control that influences students' career decision-making. Adolescents who have low self-control tendencies will make career decisions without considering the consequences and responsibilities they have to endure. The subjects of this study were seven junior high school students with an age range of 14–15 years. Data collection techniques in this study used direct observation and interview techniques. The results of this study showed that the students who were interviewed said they made career decisions of their own free will, but some of them were due to their parents, and some made decisions after considering their family circumstances. Based on the results of research on self-control in students' career decision-making, it was found that the contribution of self-control to decision-making abilities was still quite low but had a positive direction. so that the higher the student's self-control, the more influential he is in his decision-making.

Keywords: self-control, adolescents, and adolescent behavior.
Peningkatan Hasil Belajar Fisika Melalui Pendekatan Konstruktivisme Dengan Metode Siklus Belajar Karplus
Authors: Sela Maria Rosina Wea
Published: November 2023

Penelitian ini bertujuan untuk meningkatkan hasil belajar fisika siswa kelas XII MIA 1 di SMA Negeri 1 Amarasi melalui pendekatan Konstruktivisme dengan metode siklus belajar Karplus. Penelitian menggunakan metode Penelitian Tindakan Kelas (PTK) dengan 37 siswa sebagai subjek. Penelitian terdiri dari dua siklus, masing-masing dengan empat pertemuan, termasuk tiga proses pembelajaran dan satu tes siklus. Hasil penelitian menunjukkan peningkatan yang signifikan dalam hasil belajar siswa. Pada siklus I, persentase hasil belajar adalah 37,83%, yang meningkat menjadi 94,59% pada siklus II. Hasil observasi afektif menunjukkan peningkatan dari 54,18% pada siklus I menjadi 81,26% pada siklus II. Evaluasi psikomotorik juga mengalami peningkatan, dari 65,16% menjadi 74,47%, mencapai kategori baik. Dengan demikian, pelaksanaan Pendekatan Konstruktivisme dengan Metode Siklus Belajar Karplus efektif dalam meningkatkan hasil belajar siswa dalam mata pelajaran Fisika di kelas XII MIA 1 SMA Negeri 1 Amarasi. Implikasinya adalah penggunaan metode ini sebagai alternatif pembelajaran di sekolah tersebut dan sebagai acuan untuk penelitian lebih lanjut dalam konteks pendekatan konstruktivisme dan metode siklus belajar Karplus pada mata pelajaran lain.
KEBAHAGIAAN PASIEN RUMAH SINGGAH GAJAH MADA DINAS SOSIAL SURAKARTA
Authors: Arfinzah Pramudya Yudhistira  , Faqih Purnomosidi
Published: November 2023

Happiness is an important psychological aspect in the recovery and well-being of the patient. A positive emotional state, a feeling of satisfaction, and a good quality of life greatly contribute to the successful treatment and recovery of the patient,.It is therefore important to understand the factors that influence the happiness of patients in Surakarta social service halfway housesThis study aims to explore and analyze the fulfillment of patient happiness in social service halfway house Surakarta. the research method in this writing is qualitative with interview / interview, and observation. On the happiness of patients Gajah Mada halfway house surakarta social services. The results of the study patient happiness halfway house gajah Mada social service Surakarta feel quite good happiness while living while in a halfway house due to the fulfillment of the needs of food ,drink and clothing that much.patients feel comfortable during worship.
Analisis Semiotika Pada Puisi “Bunga dan Tembok” Karya Wiji Thukul
Authors: Eri Ramdani
Published: November 2023

This study aimed to rebuild the sense of nationalism that has started to fade as a result of the rapid development of the era. Undeniably, right now, most of the people prefer to share their ideas in social media and perhaps only a few who create their ideas into a useful work. Basically, an idea turns into a written work such as poem can be used as a motivation for other people. In fact, in new order regime when the nation’s youth got their right seized and all their activities limited, many people were against that. But, not as brave as Wiji Thukul who stand bravely fighting all the injustice. Wiji deployed literature in his fight, using words to evoke the spirit of the nation’s youth at that time. Just like in his poem entitle “Bunga dan Tembok” (warning). Up until now, the poem is still popular because of the meaning that represent the feeling of the people who feel the unfairness of the country. The poem was intended for dictator who seize people’s right. In conclusion, poem can be used as a weapon, and a literature work depend on how it is delivered and written.
Private Practice Infectious Disease: Metro Infectious Disease Consultants
Authors: Petrak Russell , Fliegelman Robert , Van Hise Nicholas , Chundi Vishnu , Didwania Vishal , Han Alice , Harting Brian
Published: November 2023

Despite the stimulating nature of infectious diseases (ID), fellowship programs have failed, on a yearly basis, to fill multiple positions. In addition, numerous entities have published information showing that infectious disease physicians are poorly reimbursed compared to their colleagues in other specialties and are likely to feel overwhelmed. To assess the status of our ID group and define opportunities for improvement, Metro Infectious Disease Consultants (MIDC) conducted an internal audit. Eighty-nine percent of physician employees and 94% of partners were satisfied or very satisfied with MIDC. In addition, based on a Medscape survey, MIDC employees received financial compensation that was 18% greater and partners 235% greater than the average for all ID physicians. A private practice model of infectious diseases is a viable, lucrative, and professionally stimulating option to other ID models. This allows for enhanced lifestyle flexibility and should be viewed by potential ID applicants as a realistic and widely available option to practice this dynamic specialty.
Town or Gown? ID Needs Both
Authors: Segreti John
Published: November 2023

In 1978, Robert G. Petersdorf, MD, made the statement that the war against infectious diseases had been won and that additional ID specialists were no longer necessary. He went on to say that if additional specialists were trained, they would end up culturing one another [1]. He continued that: Infectious disease is destined to function best as an academic specialty whose trainees should pursue careers primarily as investigators. The number of clinicians leaving training should be reduced and not further glut the marketplace; they should be based in academic divisions and devote their clinical time and effort to the care of complex referral and to indigent patients
El sueño de lo real
Authors: D’Odorico Gabriela
Published: November 2023

La tecnología digital parece evaporar nuestro entorno material. El trabajo y los vínculos con las cosas empiezan a pasar a la “modalidad virtual”. Sin embargo, el cuerpo no queda eximido del sufrimiento físico y psíquico. Su materialidad continúa sosteniendo las exigencias y aceleraciones de la producción capitalista.

Las preguntas acerca de qué es la realidad parecían dormidas hasta que la revolución tecnológica digital las despertó. ¿Qué es lo real en el mundo técnico que habitamos? ¿Cómo distinguir verdad o ficción en lo que muestran las pantallas? ¿De qué manera la tecnología modifica la vida, los cuerpos y las pasiones? ¿Qué significaría que los objetos tecnológicos sean autoconscientes? Son preguntas metafísicas que, con el tecnocapitalismo, cobran un nuevo significado. Los denominados “nuevos realismos” ensayan respuestas incipientes, que este libro retoma. El texto se organiza en tres partes que reflexionan acerca de lo real: “La política piensa lo real”, “El arte piensa lo real” y “Los cuerpos piensan lo real”.
Signals mediating Klotho-induced neuroprotection in hippocampal neuronal cells
Authors: Cheng Meng-Fu , Chen Li-Jen , Niu Ho-Shan , Yang Ting-Ting , Lin Kao-Chang , Cheng Juei-Tang
Published: November 2023

The erythropoietin (Epo) receptor (EpoR) is expressed in the brain and was shown to have neuroprotective effects against brain damage in animal models. A recent study indicated that EpoR and its activity are the downstream effectors of Klotho for cytoprotection in the kidney. Thus, we propose that Klotho can stimulate the expression of EpoR in neuronal cells to enhance Epo-mediated protection. H19-7 hippocampal neuronal cells were treated with recombinant Klotho. In H19-7 cells, Klotho increased the expression of both the EpoR protein and mRNA. Klotho also enhanced the transcription activity of the EpoR promoter in H19-7 cells. Moreover, Klotho augmented the Epo-triggered phosphorylation of Jak2 and Stat5 and protected H19-7 cells from hydrogen peroxide cytotoxicity. The silencing of EpoR abolished the protective effect of Klotho against peroxide-induced cytotoxicity. Finally, the silencing of GATA1 diminished the Klotho-induced increase in EpoR protein and mRNA expression as well as its promoter activity. In conclusion, Klotho increased EpoR expression in neuronal cells through GATA1, thereby enabling EpoR to function as a cytoprotective protein against oxidative injury.
Zolpidem withdrawal induced uncoupling of GABAA receptors in vitro associated with altered GABAA receptor subunit mRNA expression
Authors: Jembrek Maja , Vlainić Josipa , Šuran Jelena
Published: November 2023

Hypnotic zolpidem produces its effects via the benzodiazepine binding site in α1-containing GABAA receptors. The aim of the study was to assess the influence of duration of zolpidem treatment and its withdrawal, as well as the role of alpha1-containing GABAA receptors in the development of physical dependence and tolerance. Namely, recombinant receptors can be used to characterize mechanisms involved in different processes in the brain and to delineate the contribution of specific receptor subtypes. To address the influence of chronic zolpidem treatment we exposed HEK293 cells stably expressing alpha1beta2gamma2S recombinant GABAA receptors for seven consecutive days, while withdrawal periods lasted for 24, 48, 72 and 96 hours. Using radioligand binding studies we determined that chronic zolpidem treatment did not induce changes in either GABAA receptor number or in the expression of subunit mRNAs. We observed the enhancement of binding sites and upregulated expression of subunit mRNAs only following 96-hour withdrawal. Moreover, zolpidem treatment and its withdrawal (All time points) induced functional uncoupling between GABA and benzodiazepine binding sites in the GABAA receptor complex. Accordingly, it might be assumed that zolpidem withdrawal-induced uncoupling of GABAA receptors is associated with altered GABAA receptor subunit mRNA expression. The results presented here provide an insight into molecular and cellular mechanisms probably underlying adaptive changes of GABAA receptor function in response to chronic usage and withdrawal of zolpidem and perhaps the observed molecular changes could be linked to the tolerance and dependence produced upon prolonged treatment with other GABAergic drugs.
Trigemino-hypoglossal somatic reflex in the pharmacological studies of nociception in orofacial area
Authors: Zubrzycki Marek , Janecka Anna , Zubrzycka Maria
Published: November 2023

Disorders involving the orofacial area represent a major medical and social problem. They are a consequence of central nociceptive processes associated with stimulation of the trigeminal nerve nucleus. A rat model of trigeminal pain, utilizing tongue jerks evoked by electrical tooth pulp stimulation during perfusion of the cerebral ventricles with various neuropeptide solutions, can be used in the pharmacological studies of nociception in orofacial area. The investigated neuropeptides diffuse through the cerebroventricular lining producing an analgesic effect either directly, through the trigemino-hypoglossal reflex arc neurons or indirectly through the periaqueductal central gray, raphe nuclei or locus coeruleus neurons. The aim of this review is to present the effect of pharmacological activity of various neuropeptides affecting the transmission of the sensory information from the orofacial area on the example of trigemino-hypoglossal reflex in rats.
Effect of extending grating length and width on human visually evoked potentials
Authors: Mihaylova Milena , Hristov Ivan , Racheva Kalina , Totev Tsvetalin , Mitov Dimitar
Published: November 2023

Visually evoked potentials (VEPs) were elicited by Gabor gratings with different lengths and widths at three spatial frequencies (SFs): low, 1.45 c/deg, medium, 2.9 c/deg and high, 5.8 c/deg and at a contrast 3 times above the detection threshold at each SF. An increase of grating length enhanced N1 amplitude at occipital and parietal positions stronger than the increase of grating width at aspect ratios (length : width) above 4:1. The stronger effect of stimulus length than width was reflected also in the amplitude of the later P1 component at central and parietal positions. The larger effect of stimulus length than width on the VEP amplitude was SF specific: it was stronger at 5.8 c/deg, smaller at 2.9 c/deg and vanished at 1.45 c/deg. The results obtained suggest anisotropy in the physiological mechanisms that underlie grating perception and involve bottom- up processes initiated in the occipital cortex.
Effects of perinatal undernutrition on the basilar dendritic arbor of the anterior cingulate pyramidal neurons in lactating dams
Authors: Salas Manuel , Torrero Carmen , Regalado Mirelta , Rubio Lorena
Published: November 2023

In altricial species, early pre- and neonatal undernutrition interferes with the neuronal organization of several brain structures that have critical time windows for synaptic organization, including the prefrontal cortex. In Golgi-Cox stained tissue the basilar dendritic arbor of pyramidal neurons in the anterior cingulate cortex of early underfed adult lactating dams was evaluated. The anterior cingulate of the rat plays a major role in the execution of sexual, maternal and visual attentional control and other cognitive responses. The effects of neonatal undernutrition on the basilar dendritic tree and perikaryon measurements in layer II/III pyramidal neurons of the anterior cingulate were examined in lactating dams at postpartum days 8 and 12. In the underfed dams the distal portions of the basilar dendrites had fewer branches and a lower dendritic density of dendrites, and neurons had perikarya with reduced perimeter and cross-sectional area. Thus, the neuronal alterations may interfere the plastic synaptic activity and with maternal cognitive performance of rats subjected to early underfeeding. These anatomical alterations of the anterior cingulate may help to understand the disruption of long-term cognitive processes associated with perinatal food restriction.
Relationships between typical histopathological hallmarks and the ferritin in the hippocampus from patients with Alzheimer’s disease
Authors: Kwiatek-Majkusiak Jolanta , Dickson Dennis , Tacik Paweł , Aoki Naoya , Tomasiuk Ryszard , Koziorowski Dariusz , Friedman Andrzej
Published: November 2023

Oxidative stress is one of the possible mechanisms of neurodegeneration. One of the elements of this mechanism are altered iron homeostasis and changes concerning of iron metabolism regulatory proteins. The primary iron storage protein in cells is ferritin, composed of heavy (H) and light (L) chains. In brain tissue neurons contain mainly ferritin H-chains, whereas glial cells are rich in L-chains. To the best of our knowledge, this is the first study that compares structure of ferritin and histopathological hallmarks in hippocampal tissue affected by the pathological process of Alzheimer’s disease (AD). Our data indicate a statistically significant correlation between the concentration of L chains of ferritin, the H/L ratio and the amount of senile plaques in the subiculum, CA1 and CA4 sectors of the hippocampus (p
Brain-training for physical performance: a study of EEG-neurofeedback and alpha relaxation training in athletes
Authors: Mikicin Mirosław , Orzechowski Grzegorz , Jurewicz Katarzyna , Paluch Katarzyna , Kowalczyk Marek , Wróbel Andrzej
Published: November 2023

"In recent years, EEG-neurofeedback training (EEG-NFB) has been increasingly used to optimize various brain functions. Better performance in various activities was also reported after relaxation trainings, another popular method in therapeutic practice. Both these methods are used as a part of professional coaching in sports training centers. In the present study, we aimed to evaluate the impact of such holistic training on physiological (EEG) and behavioral measures on semi-professional athletes. EEG-NFB paradigm was intended for amplification of the amplitudes of SMR (12–15 Hz) and beta1 (13–20 Hz) bands and simultaneous reduction of the amplitude of theta (4–7.5 Hz) and beta2 (20–30 Hz). Participation in NFB sessions was accompanied with self-administration of relaxing, audio-visual stimulation after each daily athletic training session. The training program resulted in the increase of alpha and beta1 power of trained participants when assessed in rest with eyes-closed. In eyes – open state, participants of the trained group maintained the same level in all frequency bands, in opposite to the control subjects, whose power decreased in the second measurement in beta1 band when compared to the first one. The trained group exhibited greater reduction of reaction times in a test of visual attention than the control group and showed improvement in several performance measures of Kraepelin's work-curve, used to evaluate speed, effectiveness and work accuracy. Together, these results present initial support for the use of holistic, neurophysiological training in sports workout."
Intra-individual reaction time variability and response preparation: an EEG study
Authors: Dankinas Denisas , Parciauskaite Vykinta , Dapsys Kastytis
Published: November 2023

"To behave more efficiently the human brain must anticipate future events with different probabilities and prepare appropriate responses. Previous studies demonstrated that participants react faster to more probable stimuli. It has been shown that this effect in reaction time reduction is related to the response preparation process. However it is still unknown what the minimum difference in stimulus probabilities is that is sufficient to elicit response preparation as measured with the EEG. Intra-individual reaction time variability indicates the stability of an individual’s response performance and provides useful information about cognitive functioning. It’s use has become prevalent in recent clinical studies. In order to extend understanding of cognitive and neural mechanisms of response stability we hypothesized that intra-individual reaction time variability relates to the response preparation process. Specifically, we hypothesized that response preparation to more probable stimuli would result in not only faster reaction time but also in a reduction of response variability. To verify this hypothesis, we tested 14 healthy subjects using reaction time and EEG as dependent measures. Two different stimuli with probabilities of 33.3% and 66.6% were assigned to two counterbalanced responses. The results of our study showed that stimulus probabilities of 66.6% and 33.3% were sufficient to elicit response preparation. Our data also revealed that response preparation to more probable stimuli speeds RT and reduces RT variability."
Assistência de enfermagem a dependentes químicos
Authors: Gonçalves Isadora de Carvalho , Penacci Fernanda Augusta , Da Rosa Victor Hugo Júlio , E Lima Stella Godoy Silva , De Oliveira Mairis Alarcão Duarte
Published: November 2023

O objetivo da pesquisa foi identificar na literatura científica dos últimos cinco anos como tem sido a assistência de enfermagem a dependentes químicos. Adotou-se como metodologia, o protocolo PRISMA para analisar a assistência de enfermagem direcionada a dependentes químicos. Utilizando a estratégia PICo, a busca foi realizada nas bases de dados LILACS e SciELO, resultando em sete artigos completos em língua portuguesa. Ao observar assistência prestada a esse público, foi possível identificar várias dificuldades para prestação de um cuidado adequado, tanto a falta de matriciamento e conhecimento dos profissionais, quanto ao preconceito e estigmas ligados ao uso da droga. Conclui-se que é fundamental os conhecimentos dos serviços prestados a usuários de substâncias, além de fornecer um treinamento adequado aos profissionais de enfermagem e a equipe multidisciplinar, assim podendo fornecer um cuidado integral a pacientes dependentes químicos melhorando a qualidade de vida deste público.
Índices de clorofila em genótipos de milho (Zea mays) com sintomas de enfezamento
Authors: Lubian Cleucir , Molin Leonardo Mateus Dal , Dudek Giandrei , Risse Nataniel Osmar , Luchese Augusto Vaghetti , Missio Vivian Carré , Missio Robson Fernando
Published: November 2023

Por ser amplamente cultivado, o milho movimenta um intenso trabalho de pesquisa, sempre na busca de cultivares mais produtivas, adaptadas ás condições ambientais e resistentes aos diversos agentes patogênicos. Ultimamente, o complexo dos enfezamentos, causado por dois molicutes e disseminado pela cigarrinha (Dalbulus maidis) se tornou o centro das atenções neste mercado, e por isso, o objetivo deste trabalho foi avaliar os índices de clorofila em genótipos de milho acometidos pelo complexo dos enfezamentos. Avaliamos os índices de clorofila A, B e Total de 60 genótipos e 3 testemunhas em plantas sadias e infectadas. Observou-se uma diminuição média de 20,9% no índice de clorofila total das plantas afetadas pelos enfezamentos, já em genótipos mais suscetíveis houve diminuição de até 50%. Híbridos comerciais apresentaram perdas médias de 19% e as cultivares crioulas 26% de diminuição no teor de clorofila total. Muitos genótipos não apresentaram diferença significativa entre o índice de clorofila de plantas sadias e doentes, demonstrando tolerância ao complexo dos enfezamentos. Além disso, constatou-se declínio no índice de clorofila nas plantas com sintomas aparentes do complexo de enfezamentos em relação ás plantas sadias, sendo possível identificar genótipos tolerantes e suscetíveis visualmente. As leituras superiores de alguns genótipos indicam características interessantes em programas de melhoramento genético ou para identificação de genes que causem esta maior tolerância ao complexo dos enfezamentos.