bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effects of (Un)Expected Match Outcomes on Stock Return: A Case Study of Borussia Dortmund
Authors: Frick Bernd , Semmelroth Dirk
Published: November 2021

Abstract: We analyze the nature of stock price reactions of Borussia Dortmund, the only publicly traded soccer club in Germany, following domestic league and international matches over an extended period of time. Our results suggest that abnormal returns vary with the match result, the match venue, the competition type, bookmakers’ expectations, and the importance of the Bundesliga match. Although our results confirm the evidence presented in previous studies, they are surprising insofar as the legal form of Borussia Dortmund GmbH & Co. KGaA—a mixture of a stock company (AG) and a limited partnership (KG)—is quite different from that of traditional stock companies. From a theoretical perspective, diluted property rights and a lack of managerial monitoring are the main characteristics of this legal form. However, the club managers’ career concerns and the competitive pressures of the football industry seem to compensate for these deficits in the organizational architecture.
In Silico of Different Gait Cycle in Customised Leg Orthosis: A Finite Element Approach
Authors: Mamat Hazri Ahmad Amirul Faiz , Ab Rashid Amir Mustakim , Abdullah Abdul Halim , Bing Wui Ng , Nasution Ahmad Kafrawi , Hong Seng Gan , Ramlee Muhammad Hanif
Published: November 2021

Leg orthosis is one of medical device for fracture bone treatment. Several complications have been reported when patients are wearing the conventional Plaster of Paris or fibreglass leg orthosis. Its including numbness due to tight application, swelling, venous congestion and skin irritation. Therefore, the aim of this study is to develop and biomechanical analyse a customized leg cast that could tackle those complications. First, the leg was scanned using a 3D scanner. The leg cast was constructed from a 3D scanned leg model and designed using 3-Matic software which later simulated in finite element analysis using Marc software. The study focuses on three gait cycles; midstance, heel strike and toe off where stress and deformation were predicted. From the results, the cast only supported the ankle in midstance phase with only 7.297MPa stress and not capable to support the ankle in heel strike and toe off phases with maximum stress of 106.99 MPa and 213.12 MPa, respectively, which are beyond its yield strength of ABS, 23MPa. The average of overall displacement occurred for both skin and cast were less than 1.5mm. In short, the cast could only support the ankle in midstance phase and cannot be used for heel strike.
The Function of Organic Additives in Enhancing the Q-values for Peat Pellet Biofuel
Authors: Nor Hashim Nor Zakiah , Embong Zaidi
Published: November 2021

In Malaysia, peat make up for around 7.5 % of the entire land area. The positive effect of the vast wet organic compounds accumulates over a long time has stored high content of soil’s carbon which are highly useful as fuel and biomass energy generation. Thus, this study gives an outline of peat pellet as potential biofuel energy.  The peat pellets were soaked into several kinds of flammable additives such as petrol, kerosene and diesel. The percentages of 69.41 % of carbon, 28.73% of oxygen and 0.97% of silicon were obtained using Energy Dispersive X-ray (EDX). The Fourier-Transformed Infrared (FTIR)- Attenuated Total Reflectance (ATR) Spectroscopy was used to identify the sample.  From the spectra, it reveals that most of the additives contribute mainly functional groups with hydroxyl, alcohol and phenol groups were found leading to higher boiling and melting points. The heat combustion properties of peat pellets were evaluated using a calorimeter technique by boiling off 50 ml and 100 ml of water. The pellet with diesel has the highest Q-values and combustion rate due to larger number of carbons in rigid molecular structure. The high amount of unique chemical compound found naturally in diesel known as cetane, ignites effortlessly when heated gives diesel additional advantages in shorter ignition delays as well as longer duration of combustion.
PROSEDUR PENILAIAN BARANG MILIK NEGARA BERUPA TANAH DAN BANGUNAN PADA KANTOR PELAYANAN KEKAYAAN NEGARA DAN LELANG (KPKNL) BOGOR
Authors: Maulana Hendri
Published: November 2021

Prosedur yang dimiliki oleh Kantor Pelayanan Kekayaan Negara dan Lelang sudah sesuai dengan SOP (Standar Operasional Prosedur) yang telah ditentukan oleh kantor tersebut. Dan untuk persyaratan penilaian sudah sesuai dengan SOP (Standar Operasional Prosedur). Adapun persyaratan prosedur berupa tanah dan bangunan , dan ada juga syarat penilain berupa verifikasi dan penyusunan laporan penilaian. Pelaksanan yang dimiliki oleh Kantor Pelayanan Kekayaan Negara dan lelang susah sesuai dengan PMK.06/2017 yang telah di tetapkan oleh DJKN (Direktur Jenderal Kekayaan Negara) oleh karena itu pelaksanaan sudah sesuai dengan SOP yang ada (Standar Operasional Prosedur), adapun persyaratan pelaksanaan penilaian yaitu : pendekatan penilaian dan laporan penilaian
ANALISIS KINERJA KEUANGAN MENGGUNAKAN METODE Z SCORE PADA PT. UNILEVER INDONESIA INDONESIA TBK
Authors: Wibowo Agung , Supramono Supramono , Kuraesin Ecin
Published: November 2021

Penelitian ini bertujuan  untuk menganalisis kinerja keuangan perusahaan dengan  metode Altman Z-Score menggunakan data sekunder yang diambil dari Bursa Efek Indonesia berupa laporan keuangan, dari perusahaan PT. Unilever Indonesia Tbk. Penelitian juga bertujuan untuk mengetahui ada tidaknya kesulitan keuangan atau pun tingkat kenerja keuangan berpotensi bankrupt atau tidak serta tingkat diantaranya yaitu wilayah abu-abu. Hasil dari perhitungan analisis Altman Z-Score pada PT Unilever Indonesia Tbk selama lima tahun  tidak  mengalami kesulitan keuangan meskipun mengalami penurunan terlihat pada tahun pertama tahun 2016 nilai Z Score sebesar 18,94, tahun 2017 mengalami penurunan menjadi 18,39 , tahun 2018 mengalami peningkatan menjadi 22,00 kemudian tahun 2018 turun menjadi 15,43 serta pada tahun 2020 turun lagi menjadi 13,90 Penurunan Z score dapat disebabkan beberapa factor seperti menurunnya penjualan yang terkait dengan pandemic Covid 19 khususnya penuruan pada tahun 2019 dan tahun 2020
PENILAIAN PENGGUNAAN DOMPET DIGITAL SAAT PANDEMI Covid-19.
Authors: Bimo Widhi Ariyo
Published: November 2021

Salah satu kegiatan masyarakat yang meningkat saat pandemi Covid-19 adalah banyaknya transaksi digital dengan menggunakan DOMPET DIGITAL. Dompet Digital adalah, aplikasi elektronik yang dapat digunakan untuk melakukan transaksi keuangan secara online, tanpa uang fisik tunai (kertas atau logam) dan tanpa kartu, pengguna tinggal menggunakan smartphone dalam melakukan transaksi keuangannya. Tujuan dari penelitian ini adalah Untuk mengetahui penilaian penilaian penggunaan dompet digital saat pandemi covid-19.metode yang digunakan adalah deskriptif kualitatif menggunakan data primer yang dikumpulkan melalui kuisioner dengan responden. Kesimpulan dari penelitian ini  menunjukan bahwa penilaian penggunaan dompet digital saat pandemi Covid-19 dari sisi Kinerja Penampilan (Tangible), Keandalan (Realibility) dan Perhatian (Empathy) adalah  baik dan dapat diandalkan sedangkan  yang perlu dilakukan peningkatan adalah dalam Kinerja Daya Tanggap (Responsivness) dan Jaminan (Assurance).
Rules for Claims and Exceptions in Cooperative Health Insurance Coverage
Authors: Motlaq Mohammad Assaf Mohammad
Published: November 2021

يتناول هذا البحث دراسة أحكام الاستثناءات في تغطيات التأمين الصحي التعاوني، وما يُقابلها من ممارسات ومطالبات حملة الوثائق التأمينية، ويهدف إلى تقويم الواقع التطبيقي للتأمين الإسلامي، باعتباره من أنواع التعاون على البر والتقوى؛ وذلك لكي يظهر معنى التعاون الحقيقي في الواقع التطبيقي، ولا يتحول التطبيق إلى تعاون على الإثم والعدوان. وقد بَيَّ البحث خصائص التأمين الصحي التعاوني وشروطه، وتوصل إلى أن الاستثناءات الجائزة هي التي لا تتعارض مع تلك الخصائص والشروط، وبالتالي لا يجوز لشركات التأمين التعاوني أن تخالف أحكام الشروط في الاستثناءات، وتلجأ في الواقع التطبيقي إلى الإذعان والتعسف في وضع استثناءات جديدة بعد العقد؛ كما لا يجوز أن يُقابل هذا التصرف من بعض حملة الوثائق التأمينية باللجوء إلى مطالبات غير مشروعة بحجة الوصول إلى الحق الذي حُرموا منه بسبب تلك الاستثناءات التعسفية.
Cryptocurrencies Economic Effects and Shari’ah Ruling
Authors: Amadou Garba  Zakaria
Published: November 2021

العملات المشفرة ظاهرة اقتصادية عالمية واسعة الانتشار، لها تداعياتها على المستوى الاقتصادي والفردي، حيث إنها تؤثر على السياسات النقدية للدولة من جهة عرض النقود نظرا لعدم تحكم الدولة في إصدارها، كما تؤثر على السياسة المالية لتسهيلها عملية التهرب الضريبي، كذا على نظام المدفوعات والائتمان لغياب الوساطة المالية في التعامل بها، إلا أنها مع ذلك تميزت في نفس الوقت بالقبول الواسع لما تتمتع به من ثقة المتعاملين لانسيابيتها في التعامل، والاستفادة منها في جميع التعاملات بيسر وسهولة عبر منصات التداول المنتشرة؛ لذا اختلف الفقهاء المعاصرون في حكم التعامل بها، بين قائل بجواز التعامل بها وأنها باقية على أصل الإباحة وقيامها بوظائف النقود، وبين قائل بعدم جواز ذلك لصدورها من السلطات غير الرسمية وشمولها على الغرر والجهالة، وبين آخر متوقف في الحكم لعدم اتضاح جميع الصور المرتبطة بها لديه. وخلص البحث إلى القول بالتوقف في الحكم للتعامل بالعملات المشفرة بشكلها الحالي، مع اعتبارها نقدا قائما بذاته، وبالتالي تسري عليها الأحكام الشرعية المتعلقة بالعملات العادية غير المشفرة من حيث التعامل نظرا لعلة الثمنية.
ANALISIS WARNA PADA FILM ANIMASI “THE GARDEN OF WORDS” KARYA MAKOTO SHINKAI
Authors: Heryanto Naldo Yanuar
Published: November 2021

Film Animasi digital dua dimensi kembali bangkit di era modern ini yang cukup bervariasi dari berbagai negara, khususnya animasi dari Jepang’ yang selain diwakilkan oleh Studio Ghibli, juga ada banyak perwakilan dari karya lainnya yang menonjolkan dari aspek dan elemen desain tertentu secara dominan. Salah satu karya animasi lainnya yang cukup memiliki pengaruh besar bagi industri animasi dengan pemikiran konsep yang mendalam dapat kita temukan pada karya Makoto Shinkai, dalam bahasan kali ini adalah film “The Garden of Words” dengan analisa yang mendalam mengenai aplikasi warna secara konseptual.
EKSPLORASI MATERIAL BUNGA MAHONI UNTUK LAMPU AROMA TERAPI DI MASA ADAPTASI KEBIASAAN BARU
Authors: Azhar Hanif
Published: November 2021

Metode eksplorasi material merupakan salah satu metode penelitian dalam pengembangan desain produk industry yang akan menghasilkan banyak peluang material produk baru. Riset ini merupakan penelitian eksplorasi material buah pohon mahoni (Swietenia macrophylla), sebuah tanaman asli Amerika latin yang sudah berkembang dengan baik di negara-negara Asia Tenggara. Tanaman ini menjadi salah satu komoditi utama sumber kayu keras untuk produk furniture. Selain kayu, tanaman ini juga menghasilkan buah yang besar mencapai 216 ton/tahun. Sayangnya, hasil samping buah mahoni ini belum dioptimalkan dan masih dianggap sampah bagi kebanyakan masyarakat. Berdasarkan observasi dan eksperimen peneliti, ternyata buah mahoni ini dapat dijadikan alternative material craft yang dapat meningkatkan nilai tambah sebuah produk dengan pendekatan eco-design. Sebuah proses treatment yang bagus akan menghasilkan produk kombinasi yang harmoni dengan kayu plywood. Eksperimen ini akan diaplikasikan ke produk lampu dekoratif aromaterapi. Hasil penelitian ini diharapkan dapat menjadi alternative kombinasi material firnitur masa depan.
DESAIN PADA KONTEKS KEBUDAYAAN
Authors: Wiyono Erina
Published: November 2021

Di jaman modern, walaupun segala sesuatu  didasari oleh logika, ilmu pasti dan teknologi, masyarakat tidak dapat melepaskan diri dari latar belakang kebudayaannya. Betapa pentingnya desainer dapat bertoleransi dalam mendesain, dan mengetahui sedikit banyak tentang budayanya ataupun budaya orang lain sehingga kenyaman client dalam menempati ruang yang didesain tercapai.
Real Time Fire Detection System with Image Processing
Authors: Soe Min Thu , Kyaw Zaw Thein Oak , Wong Wai Kit
Published: November 2021

Fire detectionsystemby image processing is a growing research in this era. There are many methods used to detect fire out, butstill need to develop an accurate method to detect fire without false alarms. This is due to the fact that many methods used RGB colour mode for detection. In this paper, mainly focuson detecting the fire effectively using thermal video from a thermal camera while in the same time the system will alert the people if fire was detected,and also observed the speed of the fire.This will enormouslybenefitto the fire fighters.With thissystem, thefire can be detected effectively while alerting the people and giving valuable information to the fire fighters fortheir job more effectively.
Developing Resources for Staff and Adapting Programing During COVID-19 at Fred Victor
Authors: Carnegie Claire
Published: November 2021

Fred Victor is an organization that supports those experiencing poverty and homelessness in Toronto. As a practicum student in the Health Promotions department at Fred Victor, I gained experience working on health promotion projects and was able to work directly with the community. Throughout the practicum, I worked on several projects to adapt Fred Victor’s services during COVID-19. First, I worked to develop a resilience toolkit for Fred Victor staff. COVID-19 has led to higher levels of stress. This prompted Fred Victor to develop tools to support their staff. I designed a toolkit that instructs managers on how to promote resilience in their supervision sessions and team meetings. This toolkit provided information on what resilience is, as well as practical actions that managers can take to promote resilience in staff. This project involved knowledge translation to convey the research on resilience to Fred Victor staff in an accessible way. Additionally, I worked to support the development of online peer support groups. Typically, Fred Victor runs weekly in-person peer support groups for community members. However, due to COVID-19, these groups had to move to an online format. I helped facilitate this transition by developing a guide for facilitating online group programming. This guide included information on the best platforms to run online programming, how to create a safety agreement, and best practices for facilitating the group. I then conducted outreach to community members to ask for their input on the format and content of the groups. These projects are important to public health as they work to meet the public health goal to improve quality of life by promoting and encouraging healthy behaviours. These projects played an important role in promoting the health of Fred Victor staff and clients during COVID-19 by providing them with support and tools to manage their mental health.
Epigenetics of skin intrinsic florescence
Authors: Guo Jiamin , Paterson Andrew , Roshandel Delnaz
Published: November 2021

Introduction & Objective: Cumulated advanced glycation end products (AGEs) in the bloodstream and tissues contribute to the pathogenesis of diabetes complications. The skin intrinsic fluorescence (SIF) is a non-invasive measurement of dermal AGEs level using spectrometer, and it can be used as a biomarker in AGEs-related diseases. Previously, specific epigenomic factor has been found to be associated with haemoglobin A1c (HbA1c). HbA1c is a type of glycated haemoglobin – the HbA1c test measures the average glycemic control over the period of 3 months. However, the effect of epigenetic factors on the level of AGEs in the skin remains unknown. We hypothesize that some cytosine-guanine dinucleotides (CpGs) are associated with SIF. An epigenome-wide associations study (EWAS) was performed to identify CpG sites associated with SIF in people with type 1 diabetes.

Methods: 499 people with type 1 diabetes that have both methylation and SIF from the Diabetes Control Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study were included. We fit linear regression models for SIF with each CpG site one at a time. The epigenome-wide significance level (p=5e-8) was applied. Then the result is compared with the null hypothesis where CpGs are not associated with SIF to check the inflation. In order to check the assumptions of the multiple linear models at a single CpG, we use diagnostic plots.

Results: We did not identify a specific CpG that is significantly associated with neither skin intrinsic fluorescence 1 (SIF1) nor skin intrinsic fluorescence 12 (SIF 12).The CpG site with strongest effect is cg06538183 ([SE] -2.73 [0.61], p = 8.72e-6) on SIF1 and cg12871967 ([SE] 2.52, 0.53, p = 2.71e-6) on SIF12.

Conclusion: We did not find any specific CpG that was significantly associated with either SIF 1 or SIF12. In general, the result suggests that DNA methylation does not impact the accumulation of AGEs in skin cells. DNA methylation data has a unique pattern of distribution that drives the non-uniform distribution of the p-values. The group of 275,301 CpGs that have means above the median and standard deviations below the median has the expected uniform p-value distribution.
Calidad de los servicios financieros de las cooperativas rurales de la provincia de Tungurahua
Authors: Jiménez-Silva Walter Ramiro , Silva-Ordoñez Iván Fernando , Padilla-Martínez Mario Patricio
Published: November 2021

Introducción. Dentro de un mundo de rápido cambio en el que se encuentra el sector de servicios financieros de las cooperativas rurales de la provincia de Tungurahua, la competitividad de las empresas representa un factor crucial a la hora de enfrentarse entre sí, sin embargo, la ausencia de innovación tecnológica debilita el mejoramiento de la calidad de los servicios en las cooperativas rurales. Objetivo. El presente trabajo de investigación ha sido elaborado tomado en cuenta “innovación tecnológica” con el propósito de identificar aspectos que contribuya para el mejoramiento de la calidad de servicios financieros de las cooperativas rurales. Metodología. Los datos obtenidos, por medio del instrumento investigativo como es la encuesta validada estadísticamente con al Alpha de Cronbach con un resultado de 0,88, con un cuestionario de 23 preguntas aplicadas a 384 clientes externos, se estimó el nivel de correlación de las variables mediante la aplicación del test de Sperman obteniendo valores significativos en el nivel 0,01. Resultados. Se pudo determinar que el grado de utilización de elementos tecnológicos es relativamente bajo. Conclusión. El cual impacta de forma relativa en el mejoramiento de la calidad de los servicios de las cooperativas rurales asentadas en la provincia de Tungurahua.
Sexualidad en adolescentes escolarizados: Un análisis comparativo de género
Authors: Valencia Valencia Angelica de Jesús , Mena Mena Mayra Cristina
Published: November 2021

Introducción: La adolescencia conlleva múltiples procesos del desarrollo humano con cambios biológicos y fisiológicos que se complementan sicológicamente con la sexualidad. Objetivo: Esta investigación tuvo como objetivo principal el comparar el conocimiento referente a educación sexual en adolescentes escolarizados entre género femenino y masculino de la Unidad Educativa Santa Rosa. Método: se realizó una comparación cuantitativa de género en 193 estudiantes de Primer Año de Bachillerato. La comparación se realizó con la utilización de una encuesta compuesta de 15 preguntas las cuales estaban divididas en tres secciones principales tales como generalidades y conceptos de términos a saber género, sexo, educación sexual como derecho humano; prevención de embarazos en adolescentes; y, otros temas de sexualidad tales como grupos minoritarios, y acoso sexual. Los datos obtenidos fueron consolidados y comparados con enfoque de género. Resultados: los resultados obtenidos indican un mayor conocimiento de sexualidad por parte de las encuestadas de género femenino; sin embargo, en forma general, existe un escaso conocimiento sobre estos temas. Conclusiones: luego de este proceso, se concluye que existe un mejor conocimiento de temas de sexualidad en la población femenina; sin embargo, hay una necesidad urgente de plantear una intervención educativa con enfoque de sexualidad con los estudiantes de la Unidad Educativa Santa Rosa.
El poder del grillete
Authors: Salazar-Sánchez Fabián
Published: November 2021

Varias entidades del Estado Ecuatoriano, han unido esfuerzos para luchar contra la corrupción y erradicar este mal que proviene no solo desde el propio Estado sino que es una estructura política delincuencial organizada
Hoy por hoy hemos observado a funcionarios sometidos a procesos penales, continuar con sus funciones para las cuales fueron elegidos por el soberano, Es preciso entender si las labores para las que fueron elegidos no se ponen en riesgo o en duda, cuando, media un proceso de índole criminal, sin que esto implique una sentencia anticipada o paralela al verdadero procesamiento.
La seguridad siempre radicará entonces en al titular que otorgó el poder para que este se ejecute con fidelidad, sin que conlleve a un gobierno de la corrupción o al poder del grillete.
As potencialidades da ora-pro-nóbis (Pereskia aculeata Mill.) no Programa Nacional de Alimentação Escolar
Authors: Simonetti Mariana Grisa , Fariña Luciana Oliveira de , Simonetti Kerli Tatiane Grisa
Published: November 2021

A aquisição de alimentos diversificados e locais tendo como foco o desenvolvimento rural sustentável está entre as diretrizes do Programa Nacional de Alimentação Escolar. De ampla aplicação culinária, alta adaptabilidade e baixo custo de produção, a ora-pro-nóbis (Pereskia aculeata Mill.) é uma Planta Alimentícia Não Convencional nativa brasileira com elevado teor de aminoácidos essenciais, fibras, ferro e carotenoides, sendo considerada uma alternativa para a melhorara da qualidade nutricional, da valorização da biodiversidade e do incentivo à agricultura familiar local. O estudo de caráter exploratório tem por objetivo analisar o potencial desta representante da biodiversidade brasileira a partir de uma ação de Educação Alimentar e Nutricional à alunos de 8 a 10 anos de uma escola de Capitão Leônidas Marques – PR. Um questionário semiestruturado foi utilizado para avaliar a aceitabilidade da ora-pro-nóbis (Pereskia aculeata Mill.) na alimentação e o conhecimento a respeito de plantas alimentícias não convencionais. A ação envolveu quatro receitas pré-estabelecidas com uso desta planta e o retorno dos alunos quanto a prática proposta, indicou boa aceitação das preparações. A natureza esta a nossa volta, cabe a nós percebê-la e dar seu devido valor, com isso, este estudo abre portas para o mundo de espécies subutilizadas e tradicionais com potencial alimentício disponíveis na biodiversidade. Temas como este contribuem para o rompimento da monotonia alimentar, transformação dos sistemas alimentares e promoção da Segurança Alimentar e Nutricional da população.
Prevalência de sintomas de refluxo gastroesofágico e o impacto na qualidade de vida em estudantes de Medicina em uma Instituição de Ensino Superior do Centro-Oeste
Authors: Cardoso Thais Carolina Alves , Fleury Lygia Gomes , Carvalho Júlia Cândido , Carneiro Raphael Machado , Lins Alane Franco , Rebelo Bianca Rosa Rodrigues , Oliveira Danúbio Antônio de
Published: November 2021

A Doença do Refluxo Gastroesofágico (DRGE) foi definida pelo como uma doença crônica consequente do fluxo retrógrado, apresentando parte do conteúdo gastroduodenal para o esôfago e/ou órgãos adjacentes a ele. Dessa forma, o presente estudo tem como objetivo avaliar a prevalência dos sintomas de refluxo gastroesofágico e seu impacto na qualidade de vida nos estudantes de medicina do 1º ao 8º período de uma instituição de ensino superior da região Centro-Oeste. Trata-se de um estudo epidemiológico, observacional, descritivo, transversal e de natureza quantitativa e apresenta um cálculo amostral de 264 estudantes. Em relação a prevalência dos sintomas da DRGE, a maior delas a azia, seguido de se sentir estufado ou cheio após uma alimentação normal. Estudantes que praticam exercícios físicos regularmente são menos acometidos pelos sintomas de DRGE, e, apesar de alguns entrevistados tomarem remédio para controle dos sintomas, a maioria ainda relata sofrer com a presença destes. Mostrou-se ainda uma relação inversa (fator de proteção) entre pratica de exercício físico estufamento; e uso de medicamentos e a presença de azia, regurgitação, dor no peito e estufamento. Em relação ao escore final do questionário “GERD Score” foi observado uma média geral de 5,068, resultado que considera significativo o impacto dos sintomas da DRGE. Já sobre o questionário “HBQOL”, a média geral dos domínios foi de 16,12, indicando ótimo nível de qualidade de vida. Entretanto, percebeu-se que apesar da média da qualidade de vida ser boa, os sintomas da DRGE interferem em todos os domínios de qualidade de vida dos indivíduos.
Agricultura orgânica no oeste do Paraná: um estudo sobre o município de Marechal Cândido Rondon
Authors: Costa Junior Juscelino Martins , Gonzalez Aline Costa , Exime Ethol , Costa Mariell Lima , Reis Cleoson Moura dos , Ahlert Alvori , Mattia Vinícius
Published: November 2021

Este trabalho teve como objetivo caracterizar os agricultores orgânicos certificados no município de Marechal Cândido Rondon – PR. Pesquisa de natureza qualitativa e quantitativa, estruturada analiticamente com dados obtidos do Censo Agropecuário de 2017, do Instituto Brasileiro de Geografia e Estatística (IBGE), e do Cadastro Nacional de Produtores Orgânicos, além de um levantamento bibliográfico sobre a produção, alimentos e certificação orgânica. O estudo revelou que do universo de 1.934 estabelecimentos agrícolas do município, apenas 47 (2,4%) utilizam o sistema orgânico de produção, cuja certificação é realizada pela Associação Ecovida de Certificação Participativa, Instituto de Tecnologia do Paraná e Ecocert Brasil Certificadora. Observou-se que 33 estabelecimentos são de agricultores familiares e 14 unidades de produção não familiares, onde a produção articula-se somente em cultivos (35) ou criações (5) e sistemas misto (7), em propriedades que a área varia de cerca de 0,5 a 20 hectares, e a gestão de 35 propriedades são realizadas por homens e 12 estabelecimentos agrícolas por mulheres. O estudo conclui, que apesar da pouca expressividade quantitativa de agricultores orgânicos no município, a produção orgânica representa um caminho para a transição da produção sustentável de alimentos, por incluir agricultores familiares e não familiares.
Inserção social - preconceito e deficiente auditivo
Authors: Souza Ivanete Vasconcelos de , Xavier Marcos Gabriel de Oliveira
Published: November 2021

O artigo tem como foco evidenciar a inclusão das pessoas com deficiência auditiva no mercado de trabalho uma perspectiva da psicologia social no amparo dessas pessoas com deficiência auditiva (PCDA). Assim a psicologia social visa encontrar soluções para inserir as pessoas com deficiência no mercado de trabalho onde elas possam gozar de uma boa qualidade de vida. Sem maiores impactos psicossociais ao ingressarem no marcado de trabalho, mesmo sabendo que as políticas públicas são parcialmente eficazes. O objetivo geral visou discutir sobre os desafios das pessoas com deficiência auditiva no mercado de trabalho. A metodologia da pesquisa foi de natureza bibliográfica, descritiva e qualitativa. Por fim, mostrar que as políticas públicas não garantem o acesso ao mercado de trabalho para as (PCDA), por ser parcialmente ineficaz , ou seja, ineficiente em garantir a inclusão social da (PCD) no mercado de trabalho, pelo fato de não haver uma cobrança devida do setor público e privado, é tão difícil incluir socialmente a (PCDA) no mercado de trabalho, porque ainda existem muitos preconceitos e discriminações, muito embora, as pessoas com deficiência tenham os mesmos direitos, ainda falta muito empenho do poder público e também da sociedade no combate ao preconceito e a discriminação em relação a inserção das pessoas com deficiência, e precisam ser respeitadas na sua integralidade, como afirma o estatuto da pessoa com deficiência por meio da Lei 13.146/2015, que estabelece assegura e promove, a todas as pessoas com deficiência, condições iguais, exercício dos direitos e das liberdades fundamentais.
Reabilitação oral em coroa cerâmica através do fluxo digital: relato de caso
Authors: Abreu Layana Oliveira de , Romão Clara Berthyne Pinheiro , Alves Jackeline Vieira , Pinheiro Karyne Neyva Braga , Silva Gustavo Medeiros Toscano da , Oliveira Marcos Alexandre Casimiro de , Sousa Raulison Vieira de , Coura Rosalya Maria , Oliveira Natália Vieira Soares Gadelha de , Oliveira Júnior José Klidenberg de
Published: November 2021

A Odontologia digital consegue progressivamente dentro da prática clínica, dominar as adversidades relacionadas às técnicas convencionais de moldagem, pois os mecanismos com IOS (scanner intraoral) dar mais conforto ao paciente, otimiza o tempo de trabalho e oferece uma previsão do tratamento. Deste modo, a seleção do tipo de cerâmica vai influenciar na conservação da restauração. O objetivo deste estudo, foi relatar um caso clínico de reabilitação de um molar superior com a contribuição do fluxo digital, para obtenção de uma coroa total metalfree. Prontamente após o parecer clínico-radiográfico, elegeu-se um tratamento para o paciente, que consistia na troca de uma coroa fraturada em dissilicato de lítio injetada por uma fresada. O preparo expulsivo foi realizado com as brocas 2067 para o preparo dos ângulos externos retos e os internos com a 4138 para deixá-los arredondados. Quanto a cimentação, a melhor opção para este caso foi o cimento resinoso autoadesivo de polimerização dual. Por meio da execução deste trabalho, tornou-se viável a reabilitação dentária do paciente, capaz de incentivar e auxiliar nos próximos estudos em prótese fixa, executada no workflow digital por intermédio do scanner, de manejo simples e escaneamento definido.
Selected factors related to physical activity among persons with heart failure in a university-affiliated hospital, Bangkok, Thailand
Authors: Saiwutthikul Sittigorn , Siripitayakunkit Apinya , Duangbubpha Sumolchat
Published: November 2021

Background: Heart failure is a complex clinical syndrome that disturbs physical and psychological health and the quality of life of persons with heart failure and their families. Physical activity is one of the essential self-care in persons with heart failure, which can decrease the exacerbation of the heart failure symptoms, increase activity tolerance, ability to accomplish daily activities, and improve quality of life.
Objectives: This research aimed to determine the physical activity level among persons with heart failure and explore the relationship between physical activity and its related factors based on the self-and family management framework, including motivation, functional ability, family support, and perceived quality of patient-provider relationships.
Methods: A correlational cross-sectional study was conducted with a total of 70 participants who visited the Multidisciplinary Heart Failure Clinic of a university-affiliated hospital, Bangkok, Thailand, from December 2020 to May 2021. Participants were asked to complete five questionnaires that explored their physical activity and its related factors. Data were analyzed and reported using descriptive statistics and correlation coefficient, and the p-value of .05 was considered to be statistically significant.
Results: The results showed most participants (78.50%) had a high physical activity level, and the other participants (21.50%) had a moderate physical activity level. Regarding the relationship between physical activity and its related factors, a total physical activity had a significant positive correlation with a functional ability (rs = .309, p < .05), and family support (r = .210, p < .05). While the physical activity had a positively non-significant correlation with motivation (r = .050, p > .05), and a negatively non-significant correlation with perceived quality of patient-provider relationships (r = -.049, p > .05).
Conclusion: The research can be used to gain more understanding of physical activity among persons with heart failure. Nurses play an accountable role in promoting and providing appropriate interventions to constantly maintain and enhance physical activity as secondary prevention in persons with heart failure. Additionally, measuring physical activity using an objective measurement with the self-report should be considered for the favorable outcome.
Production of Recombinant Laccase From Coprinopsis cinerea and Its Effect in Mediator Promoted Lignin Oxidation at Neutral pH
Authors: Kontro Jussi , Lyra Christina , Koponen Milla , Kuuskeri Jaana , Kähkönen Mika A. , Wallenius Janne , Wan Xing , Sipilä Jussi , Mäkelä Miia R. , Nousiainen Paula , Hildén Kristiina
Published: November 2021

Laccases are multi-copper oxidases that use molecular oxygen as the electron acceptor to oxidize phenolic and indirectly also non-phenolic substrates by mechanisms involving radicals. Due to their eco-friendliness and broad substrate specificity, laccases span a wide range of biotechnological applications. We have heterologously expressed a laccase from the coprophilic basidiomycete Coprinopsis cinerea (CcLcc9) in the methylotrophic yeast Pichia pastoris. The recombinant CcLcc9 (rCcLcc9) oxidized 2,6-dimethoxyphenol in the neutral pH range, and showed thermostability up to 70°C. The rCcLcc9 efficiently oxidized veratryl alcohol to veratraldehyde in the presence of low molecular weight mediators syringyl nitrile, methyl syringate and violuric acid, which are syringyl-type plant phenolics that have shown potential as natural co-oxidants for lignocellulosic materials. In addition, rCcLcc9 is able to depolymerize biorefinery hardwood lignin in the presence of methyl syringate and syringyl nitrile as indicated by gel permeation chromatography, and infrared spectral and nucleic magnetic resonance analyses. Furthermore, we showed that several added-value aromatic compounds, such as vanillin, vanillic acid, syringaldehyde, syringic acid and p-hydroxybenzoic acid, were formed during sequential biocatalytic chemical degradation of biorefinery lignin, indicating that rCcLcc9 harbors a great potential for sustainable processes of circular economy and modern biorefineries.
Design of a Flexible Wasp-Inspired Tissue Transport Mechanism
Authors: de Kater Esther P. , Sakes Aimée , Bloemberg Jette , Jager David J. , Breedveld Paul
Published: November 2021

Tissue transport is a challenge during Minimally Invasive Surgery (MIS) with the current suction-based instruments as the increasing length and miniaturisation of the outer diameter requires a higher pressure. Inspired by the wasp ovipositor, a slender and bendable organ through which eggs can be transported, a flexible transport mechanism for tissue was developed that does not require a pressure gradient. The flexible shaft of the mechanism consists of ring magnets and cables that can translate in a similar manner as the valves in the wasp ovipositor. The designed transport mechanism was able to transport 10wt% gelatine tissue phantoms with the shaft in straight and curved positions and in vertical orientation against gravity. The transport rate can be increased by increasing the rotational velocity of the cam. A rotational velocity of 25 RPM resulted in a transport rate of 0.8 mm/s and increasing the rotation velocity of the cam to 80 RPM increased the transport rate to 2.3 mm/s though the stroke efficiency decreased by increasing the rotational velocity of the cam. The transport performance of the flexible transport mechanism is promising. This means of transportation could in the future be an alternative for tissue transport during MIS.
Analysis of Intestinal Microflora and Metabolites From Mice With DSS-Induced IBD Treated With Schistosoma Soluble Egg Antigen
Authors: Zhu Tianyu , Xue Qingkai , Liu Yiyun , Xu Yongliang , Xiong Chunrong , Lu Jin , Yang Haitao , Zhang Quan , Huang Yuzheng
Published: November 2021

Objective: This study aimed to analyze the changes in intestinal flora and metabolites in the intestinal contents of mice with inflammatory bowel disease (IBD) to preliminarily clarify the mechanism of action of Schistosoma soluble egg antigen (SEA) on IBD, thus, laying a research foundation for the subsequent treatment of IBD.

Methods: A total of 40 Institute of Cancer Research (ICR) mice were divided into four groups: control, SEA 50 μg, dextran sulfate sodium salt (DSS), and SEA 50 μg + DSS. The overall state of the animals was observed continuously during modeling. The colonic length was measured after 10 days of modeling. The degree of colonic inflammation was observed by hematoxylin and eosin staining. 16srRNA and liquid chromatography–mass spectrometry sequencing techniques were used to determine the abundance of bacteria and metabolites in the intestinal contents of mice in the DSS and SEA 50 μg + DSS groups, and the differences were further analyzed.

Results: After SEA intervention, the disease activity index score of mice with IBD decreased and the colon shortening was reduced. Microscopically, the lymphocyte aggregation, glandular atrophy, goblet cell disappearance, and colonic inflammation were less in the SEA 50 μg + DSS group than in the DSS group (p < 0.0001). After SEA intervention, the abundance of beneficial bacteria prevotellaceae_UCG-001 was upregulated, while the abundance of the harmful bacteria Helicobacter, Lachnoclostridium, and Enterococcus was downregulated in the intestinal tract of mice with IBD. The intestinal metabolite analysis showed that SEA intervention decreased the intestinal contents of glycerophospholipids (lysophosphatidylcholine, lysophosphatidylethanolamine, phatidylcholine, and phatidylethanolamine) and carboxylic acids (L-alloisoleucine and L-glutamate), whereas increased bile acids and their derivatives (3B,7A,12a-trihydroxy-5A-cholanoic acid and 3A,4B, 12a-trihydroxy-5b-cholanoic acid). Combined microbiota–metabolite analysis revealed a correlation between these differential microbiota and differential metabolites. At the same time, the changes in the contents of metabolites and differential metabolites in the two groups also correlated with the abundance of the gut microbiome.

Conclusions: The study showed that SEA reduced DSS-induced inflammation in IBD and improved the symptoms of IBD in mice through the combined regulation of intestinal flora and intestinal metabolism. It suggested a potential possibility for the use of SEA in treating and regulating intestinal flora and metabolism in patients with IBD.
Evaluation of Marine Gravity Anomaly Calculation Accuracy by Multi-Source Satellite Altimetry Data
Authors: Liu Shanwei , Li Yinlong , Sun Qinting , Wan Jianhua , Jiao Yue , Jiang Jinghui
Published: November 2021

The purpose of this paper is to analyze the influence of satellite altimetry data accuracy on the marine gravity anomaly accuracy. The data of 12 altimetry satellites in the research area (5°N–23°N, 105°E–118°E) were selected. These data were classified into three groups: A, B, and C, according to the track density, the accuracy of the altimetry satellites, and the differences of self-crossover. Group A contains CryoSat-2, group B includes Geosat, ERS-1, ERS-2, and Envisat, and group C comprises T/P, Jason-1/2/3, HY-2A, SARAL, and Sentinel-3A. In Experiment I, the 5′×5′ marine gravity anomalies were obtained based on the data of groups A, B, and C, respectively. Compared with the shipborne gravity data, the root mean square error (RMSE) of groups A, B, and C was 4.59 mGal, 4.61 mGal, and 4.51 mGal, respectively. The results show that high-precision satellite altimetry data can improve the calculation accuracy of gravity anomaly, and the single satellite CryoSat-2 enables achieving the same effect of multi-satellite joint processing. In Experiment II, the 2′×2′ marine gravity anomalies were acquired based on the data of groups A, A + B, and A + C, respectively. The root mean square error of the above three groups was, respectively, 4.29 mGal, 4.30 mGal, and 4.21 mGal, and the outcomes show that when the spatial resolution is satisfied, adding redundant low-precision altimetry data will add pressure to the calculation of marine gravity anomalies and will not improve the accuracy. An effective combination of multi-satellite data can improve the accuracy and spatial resolution of the marine gravity anomaly inversion.
The Asymmetric Precipitation Evolution in Weak Landfalling Tropical Cyclone Rumbia (2018) Over East China
Authors: Tang Lichun , Wang Yuqing , Yu Zifeng , Wang Lan
Published: November 2021

The rainfall in landfalling TC is not always correlated with the storm intensity. Some weak landfalling TCs could bring extremely heavy rainfall during and after landfall. Such extreme events are very challenging to operational forecasts and often lead to disasters in the affected regions. Tropical storm Rumbia (2018) made its landfall in Shanghai with weak intensity but led to long-lasting and increasing rainfall to East China. The asymmetric rainfall evolution of Rumbia during and after its landfall was diagnosed based on the fifth generation European Centre for Medium-Range Weather Forecasting (ECMWF) reanalysis (ERA5) data, the tropical cyclone (TC) best-track data, and rainfall observations from China Meteorological Administration (CMA). Results showed that Rumbia was embedded in an environment with a deep-layer (300–850 hPa) southwesterly vertical wind shear (VWS). The maximum rainfall mostly occurred downshear-left in its inner-core region and downshear-right in the outer-core region. The translation of Rumbia also contributed to the rainfall distribution to some extent, especially prior to and just after its landfall. The strong southwesterly-southeasterly summer monsoon flow transported water vapor from the tropical ocean and the East China Sea to the TC core region, providing moisture and convective instability conditions in the mid-lower troposphere for the sustained rainfall even after Rumbia moved well inland. The results also showed that the low-level convective instability and the deep-layer environmental VWS played an important role in deepening the inflow boundary layer and the redevelopment of the secondary circulation, thus contributing to the heavy rainfall in the northeast quadrant of Rumbia after its landfall. However, further in-depth studies are recommended in regard of the rainfall evolution in the weak TCs. This study further calls for a continuous understanding of the involved physical processes/mechanisms that are responsible for the extreme rainfall induced by landfalling TCs, which can help improve the rainfall forecast skills and support damage mitigation in the future.
Use of Induced Pluripotent Stem Cells to Build Isogenic Systems and Investigate Type 1 Diabetes
Authors: Armitage Lucas H. , Stimpson Scott E. , Santostefano Katherine E. , Sui Lina , Ogundare Similoluwa , Newby Brittney N. , Castro-Gutierrez Roberto , Huber Mollie K. , Taylor Jared P. , Sharma Prerana , Radichev Ilian A. , Perry Daniel J. , Fredette Natalie C. , Savinov Alexei Y. , Wallet Mark A. , Terada Naohiro , Brusko Todd M. , Russ Holger A. , Chen Jing , Egli Dieter , Mathews Clayton E.
Published: November 2021

Type 1 diabetes (T1D) is a disease that arises due to complex immunogenetic mechanisms. Key cell-cell interactions involved in the pathogenesis of T1D are activation of autoreactive T cells by dendritic cells (DC), migration of T cells across endothelial cells (EC) lining capillary walls into the islets of Langerhans, interaction of T cells with macrophages in the islets, and killing of β-cells by autoreactive CD8+ T cells. Overall, pathogenic cell-cell interactions are likely regulated by the individual’s collection of genetic T1D-risk variants. To accurately model the role of genetics, it is essential to build systems to interrogate single candidate genes in isolation during the interactions of cells that are essential for disease development. However, obtaining single-donor matched cells relevant to T1D is a challenge. Sourcing these genetic variants from human induced pluripotent stem cells (iPSC) avoids this limitation. Herein, we have differentiated iPSC from one donor into DC, macrophages, EC, and β-cells. Additionally, we also engineered T cell avatars from the same donor to provide an in vitro platform to study genetic influences on these critical cellular interactions. This proof of concept demonstrates the ability to derive an isogenic system from a single donor to study these relevant cell-cell interactions. Our system constitutes an interdisciplinary approach with a controlled environment that provides a proof-of-concept for future studies to determine the role of disease alleles (e.g. IFIH1, PTPN22, SH2B3, TYK2) in regulating cell-cell interactions and cell-specific contributions to the pathogenesis of T1D.
Effects of SDF-1/CXCR7 on the Migration, Invasion and Epithelial-Mesenchymal Transition of Gastric Cancer Cells
Authors: Shi Ameng , Wang Ting , Jia Miao , Dong Lei , Shi Haitao
Published: November 2021

We found that SDF-1/CXCR7 axis played an important role in the growth and proliferation of gastric cancer in the previous studies. The objectives of this study were to explore the effects of SDF-1/CXCR7 on the metastatic ability of gastric cancer cells and the possible mechanisms. CXCR7 expression in SGC-7901 gastric cancer cells was stably knocked down via lentiviral vectors. The cell migration and invasion abilities were detected by transwell migration and invasion assays. The expressions of matrix metalloproteinase 2 (MMP-2), MMP-9, vascular endothelial growth factor (VEGF), epithelial-mesenchymal transition (EMT) markers and Akt phosphorylation were detected with real-time PCR and/or western blot. We found that SDF-1 markedly enhanced the migration and invasion abilities of SGC-7901 gastric cancer cells; CXCR7 knockdown inhibited these effects. SDF-1/CXCR7 increased the expressions of MMP-2, MMP-9 and VEGF. SDF-1/CXCR7 also downregulated E-cadherin expression but upregulated N-cadherin, vimentin and Snail expressions, suggesting that SDF-1/CXCR7 could promote the development of EMT in gastric cancer cells. Furthermore, SDF-1/CXCR7 could promote Akt phosphorylation. Our results indicated that SDF-1/CXCR7 enhanced the migration, invasion and EMT of gastric cancer cells and thus CXCR7 supression may be a strategy for inhibiting gastric cancer metastasis.
A Deep Look Into COVID-19 Severity Through Dynamic Changes in Blood Cytokine Levels
Authors: Kleymenov Denis A. , Bykonia Evgeniia N. , Popova Liubov I. , Mazunina Elena P. , Gushchin Vladimir A. , Kolobukhina Liudmila V. , Burgasova Olga A. , Kruzhkova Irina S. , Kuznetsova Nadezhda A. , Shidlovskaya Elena V. , Divisenko Elizaveta V. , Pochtovyi Andrei A. , Bacalin Valeria V. , Smetanina Svetlana V. , Tkachuk Artem P. , Logunov Denis Y. , Gintsburg Alexander L.
Published: November 2021

An excessive inflammatory response to SARS-CoV-2 is thought to be a major cause of disease severity and mortality in patients with COVID-19. Longitudinal analysis of cytokine release can expand our understanding of the initial stages of disease development and help to identify early markers serving as predictors of disease severity. In this study, we performed a comprehensive analysis of 46 cytokines (including chemokines and growth factors) in the peripheral blood of a large cohort of COVID-19 patients (n=444). The patients were classified into five severity groups. Longitudinal analysis of all patients revealed two groups of cytokines, characterizing the “early” and “late” stages of the disease course and the switch between type 1 and type 2 immunity. We found significantly increased levels of cytokines associated with different severities of COVID-19, and levels of some cytokines were significantly higher during the first three days from symptom onset (DfSO) in patients who eventually required intensive care unit (ICU) therapy. Additionally, we identified nine cytokines, TNF-α, IL-10, MIG, IL-6, IP-10, M-CSF, G-CSF, GM-CSF, and IFN-α2, that can be used as good predictors of ICU requirement at 4-6 DfSO.