bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengembangan Game Math Story Problems Menggunakan RPG Maker MZ untuk Anak 4-7 Tahun
Authors: Nuraminudin M. , Astuti Ika Asti , Susanto Sebastian Arby
Published: May 2023

This study aims to produce and test the feasibility of an RPG (Role Playing Game) Math Story Problem created using the RPG Maker MZ software. The research method used is the Research and Development method using research stages (1) needs analysis, (2) design, (3) implementation, (4) validation, (5) revision and (6) product testing. The requirements analysis stage is used to analyze competency standards, hardware and software specifications. The design stage includes storyline design, display design, flowchart and character creation in the game. The implementation stage is the stage of realizing the design into an actual product. The validation stage is carried out to assess the feasibility of the game that has been designed and created which is then determined by the experts to get the criticism and suggestions needed for improvement so that the game becomes even better. The trial phase is carried out by direct application in children's learning. This test was conducted on respondents aged 4-7 years using a questionnaire. The data obtained were processed by descriptive analysis to determine the level of feasibility of the game. The results of data analysis showed that the feasibility level according to material experts was 96% which was included in the very feasible category and children as users was 83.75% which could be categorized as very feasible.
Kelayakan dan Efektivitas Sistem Administrasi Kurikulum Menggunakan Metode User Centered Design (UCD) di MAN 2 Banjarnegara
Authors: Al Ghozali Makhfud Zakaria , Sukamta Sri
Published: May 2023

Pengelolaan pendidikan merupakan pengaturan kewenangan penyelenggaraan pendidikan suatu negara oleh pemerintah, pemerintah, provinsi, pemerintah kota/daerah, penyelenggaraan pendidikan berbasis masyarakat dan satuan pendidikan supaya proses pendidikan dapat terlaksana sesuai dengan tujuan pendidikan nasional. MAN 2 Banjarnegara sebagai salah satu instansi pendidikan dalam pelaksanaan administrasi kurikulum sudah menggunakan website. Permasalahan yang muncul antara lain menu kurikulum yang tersedia di website sekolah belum mencakup sebagian besar tugas pokok dari wakil kepala sekolah bidang kurikulum, data perangkat pembelajaran yang disetorkan secara perseorangan dirasa belum efektif serta belum adanya sistem yang secara khusus disediakan untuk mengelola administrasi kurikulum. Tujuan dari penelitian ini adalah mengembangkan sistem administrasi kurikulum yang sesuai dengan kebutuhan wakil kepalasekolah bidang kurikulum, mengetahui kelayakan dan efektivitas dari sistem administrasi kurikulum yang dikembangkan di MAN 2 Banjarnegara. Penelitian dilaksanakan dengan menerapkan metode user centered design (UCD). Metode ini merupakan metode yang menempatkan pengguna sebagai pusat dari sebuah proses pengembangan sistem. Berdasarkan hasil penelitian dan pengujian yang telah dilakukan dapat disimpulkan bahwa sistem administrasi kurikulum yang dikembangkan sudah cukup sesuai dengan kebutuhan Wakil Kepala Sekolah bidang kurikulum, hasil uji kelayakan sistem administrasi kurikulum yang diujikan pada ahli media berdasarkan standar ISO 9126 berada pada kategori sangat layak digunakan dan hasil uji efektivitas  menunjukkan bahwa sistem administrasi kurikulum sudah efektif untuk dapat menghasilkan informasi yang berkualitas karena didukung dengan kualitas sistem dan kualitas pelayanan yang baik.
Pengembangan Model Pembelajaran Blended Learning berbasis Media Sosial yang Berwawasan Lingkungan
Authors: Prasetyani Henny , Zulfa Nely , Aziz Muhammad Syifa Prasetyo
Published: May 2023

Pembelajaran secara blended learning memiliki masalah yaitu ketika pembelajaran sedang berlangsung mahasiswa menyepelekan terutama ketika pelaksanaan yang dilakukan secara online dan kesadaran mahasiswa terhadap lingkungan sekitar masih kurang. Penelitian ini bertujuan untuk mengembangkan model pembelajaran blended learning dengan memanfaatkan media sosial yang berwawasan lingkungan. Pengembangan ADDIE merupakan suatu model pengembangan yang terdiri dari Analysis, Design, Development, Implementation, dan Evaluation yang merupakan tahapan yang dilakukan dalam penelitian ini. Teknik yang digunakan dalam pengumpulan data berupa instrumen yang terdiri dari instrumen media dan istrumen materi, kemudian dari hasil tersebut dilakukan analisis menggunakan statistik deskriptif. Hasil yang diperoleh yaitu instrumen dari pengembangan model pembelajaran secara blended learning berbasis media sosial yang berwawasan lingkungan menunjukkan hasil valid dan dapat diterapkan dalam proses pembelajaran. Kemudian hasil  angket respon dari mahasiswa menunjukkan hasil sebesar 81,07% (masuk kategori sangat kuat). Sehingga model pembelajaran blended learning yang menggunakan aplikasi media sosial dengan konten yang berwawasan lingkungan bisa untuk diterapkan dalam proses pembelajaran.
Analisis Tren Pertemuan Tatap Muka Terbatas dari Persepsi Warganet pada Twitter Menggunakan Topic Modeling
Authors: Nurlayli Akhsin , Dwiningrum Siti Irene Astuti , Alwi Ahmad Chafid , Raharjo Amrih Setyo
Published: May 2023

Salah satu dampak dari pandemi COVID-19 adalah pemberlakuan pembelajaran daring. Kegiatan pembelajaran daring banyak mengalami kendala, sehingga menyebabkan tidak tercapainya kompetensi pembelajaran dengan baik. Kemudian pemerintah memberlakukan program Pertemuan Tatap Muka Terbatas (PTMT), dan banyak tanggapan masyarakat terhadap program tersebut. Untuk mengetahui bagaimana persepsi masyarakat terhadap PTMT, kita dapat melakukan analisis terkait PTMT melalui media sosial. Karena media sosial merupakan salah satu media yang paling banyak digunakan oleh masyarakat selama pandemi untuk berkomunikasi, menyampaikan pendapat, mencari berita, dan lain-lain. Adapun analisis tren PTMT dari persepsi warganet yang dapat dilakukan adalah malalui topic modeling. Dengan mengambil data dari Twitter terkait PTMT menggunakan API (Application Programming Interface), selanjutnya memproses topic modeling dengan metode Latent Dirichlet Allocation (LDA), sebuah metode yang paling populer dan banyak digunakan pada penelitian text mining. Hasil pemodelan topik menghasilkan sepuluh klaster topik dengan nilai koheren 0,50344, dengan tiga topik yang paling banyak dibicarakan oleh warganet. Yakni tentang banyaknya tugas yang harus dikerjakan di luar jam sekolah, mereka sudah mencapai titik kebosanan menjalani sekolah dari rumah hingga menyebabkan kemalasan, dan banyak warganet yang membicarakan bahwa mereka akan melaksanakan kegiatan PTMT.
REMNANTS OF OTTOMAN LAW AND ITS APPLICATION IN CONTEMPORARY TIMES IN LEBANON AND THE ARAB WORLD
Authors: Kamaluddin Safrudin Halimiy
Published: May 2023

At the beginning of the sixteenth century (1516), the Ottomans controlled all the lands that are today within the Lebanese Republic, and their existence lasted for four hundred  years,  during which  they established  military,  security, administrative and social systems and enacted laws to improve and organize the country. Although five centuries have passed since the Ottoman presence in Lebanon, some of these laws are still in force. Some have been amended, such as the personal status law related to Islamic Law, some administrative regulations, and the municipal ordinance that the French updated during the Mandate days (1920-1943). While Ottoman laws are still strictly enforced in Lebanon, such as the Associations Law. Two sources, one legal and the other specialized in Islamic history, confirm in two separate interviews to Anadolu Agency the importance of these laws for Lebanon since their enactment until today. "Not everything old is considered  bad.  For  example,  but  not  limited to,  the Associations  Law is  an Ottoman law that enshrines freedom of association and respects Article 13 of the Constitution,  and  despite  its  promulgation  in  1909,  it  has  been  considered  a liberal law to date," says Appeals Lawyer Zakaria Yahya beast. Al-Ghoul added: "The Law of Associations is one of the most important laws issued during the Ottoman period. It is still in force to date, and it is the one who looks after the affairs of associations and how they are formed in Lebanon and the Arabs World. He  pointed  out  that  "there  is  a  legislative  decree  issued  in  1977,  which  is compared to the Ottoman Law of Associations as a recent law, but it allowed the pre-trial detention of  journalists." He continued, "From here, this comparison makes us say that the problem does not lie in the extent of the laws' antiquity, but rather in the extent to which they meet the objectives of the current legal rules."
BRIDAL SHOWER SEBAGAI RESEPSI PRA PERNIKAHAN PERSPEKTIF MASHLAHAH
Authors: Hikmah Nurul
Published: May 2023

Maraknya bridal shower sebagai pesta menyambut pernikahan menimbulkan pertanyaan dari sudut pandang Mashlahah,  karena dalam bridal shower terdapat beberapa rangkaian acara yang berbeda dari kemashlahatan yang diinginkan syara’. Misalnya, terdapat rangkaian acara dengan mencoret-coret wajah pengantin dengan gambar alat kelamin, serta menyelenggarakannya di tempat yang mewah dan glamor. Penelitian ini bertujuan untuk mengeksplorasi dan menelusuri bridal shower  dan latar belakang maraknya dijadikan sebagai resepsi pra-pernikahan, serta menganalis perspektif Mashlahah terhadap bridal shower sebagai resepsi pra-pernikahan. Penelitian ini adalah penelitian pustaka, dengan pendekatan kualitatif dan deskriptif analisis. Penelitian ini berdasarkan pada jenis sumber data sekunder. Teknik pengumpulan data yang digunakan yaitu studi dokumen, dengan teknik analisis data yaitu, content analysis. Simpulannya bahwa bridal shower sebagai resepsi pra-pernikahan belum memenuhi syarat-syarat. Mashlahah sebagaimana yang dikemukakan oleh ulama. Sesuatu yang dapat dikatakan mengandung Mashlahah, apabila ia sejalan dengan kehendak syara’ yaitu dalam rangka memelihara lima hal yang paling esensi pada manusia yaitu, memelihara agama, jiwa, akal, keturunan dan harta. Akan tetapi, kemashlahatan atau manfaat yang terdapat di dalam bridal shower baru mencapai pada tingkatan menurut akal manusia, meskipun mengalami perubahan dan penyesuaian dalam bentuk pelaksanaan, konsep, dan tujuannya.
Application of Multilevel Models in Classification and Regression Problems
Authors: Lebedev Ilya
Published: May 2023

There is a constant need to create methods for improving the quality indicators of information processing. In most practical cases, the ranges of target variables and predictors are formed under the influence of external and internal factors. Phenomena such as concept drift cause the model to lose its completeness and accuracy over time. The purpose of the work is to improve the processing data samples quality based on multi-level models for classification and regression problems. A two-level data processing architecture is proposed. At the lower level, the analysis of incoming information flows and sequences takes place, and the classification or regression tasks are solved. At the upper level, the samples are divided into segments, the current data properties in the subsamples are determined, and the most suitable lower-level models are assigned according to the achieved qualitative indicators. A formal description of the two-level architecture is given. In order to improve the quality indicators for classification and regression solving problems, a data sample preliminary processing is carried out, the model’s qualitative indicators are calculated, and classifiers with the best results are determined. The proposed solution makes it possible to implement constantly learning data processing systems. It is aimed at reducing the time spent on retraining models in case of data properties transformation. Experimental studies were carried out on several datasets. Numerical experiments have shown that the proposed solution makes it possible to improve the quality processing indicators. The model can be considered as an improvement of ensemble methods for processing information flows. Training a single classifier, rather than a group of complex classification models, makes it possible to reduce computational costs.
A Systematic Study of Artificial Intelligence-Based Methods for Detecting Brain Tumors
Authors: Kumar Sanjeet , Pilania Urmila , Nandal Neha
Published: May 2023

The brain is regarded as one of the most effective body-controlling organs. The development of technology has enabled the early and accurate detection of brain tumors, which makes a significant difference in their treatment. The adoption of AI has grown substantially in the arena of neurology. This systematic review compares recent Deep Learning (DL), Machine Learning (ML), and hybrid methods for detecting brain cancers. This article evaluates 36 recent articles on these techniques, considering datasets, methodology, tools used, merits, and limitations. The articles contain comprehensible graphs and tables. The detection of brain tumors relies heavily on ML techniques such as Support Vector Machines (SVM) and Fuzzy C-Means (FCM). Recurrent Convolutional Neural Networks (RCNN), DenseNet, Convolutional Neural Networks (CNN), ResNet, and Deep Neural Networks (DNN) are DL techniques used to detect brain tumors more efficiently. DL and ML techniques are merged to develop hybrid techniques. In addition, a summary of the various image processing steps is provided. The systematic review identifies outstanding issues and future goals for DL and ML-based techniques for detecting brain tumors. Through a systematic review, the most effective method for detecting brain tumors can be identified and utilized for improvement.
The Analysis of Ontology-Based Neuro-Symbolic Intelligence Methods for Collaborative Decision Support
Authors: Shilov Nikolay , Ponomarev Andrew , Smirnov Alexander
Published: May 2023

The neural network approach to AI, which has become especially widespread in the last decade, has two significant limitations – training of a neural network, as a rule, requires a very large number of samples (not always available), and the resulting models often are not well interpretable, which can reduce their credibility. The use of symbols as the basis of collaborative processes, on the one hand, and the proliferation of neural network AI, on the other hand, necessitate the synthesis of neural network and symbolic paradigms in relation to the creation of collaborative decision support systems. The article presents the results of an analytical review in the field of ontology-oriented neuro-symbolic artificial intelligence with an emphasis on solving problems of knowledge exchange during collaborative decision support. Specifically, the review attempts to answer two questions: 1. how symbolic knowledge, represented as an ontology, can be used to improve AI agents operating on the basis of neural networks (knowledge transfer from a person to AI agents); 2. how symbolic knowledge, represented as an ontology, can be used to interpret decisions made by AI agents and explain these decisions (transfer of knowledge from an AI agent to a person). As a result of the review, recommendations were formulated on the choice of methods for introducing symbolic knowledge into neural network models, and promising areas of ontology-oriented methods for explaining neural networks were identified.
El análisis etnometodológico en las ciencias humanísticas y sociales de la educación ecuatoriana
Authors: Mendoza-Velazco Derling José , Navarro-Cejas Mercedes , Morales-Intriago Juan Carlos , Cejas-Martínez Magda Francisca
Published: May 2023

El enfoque analítico etnometodologico permite obtener información relevante a través de una entrevista no estructurada en profundidad y el análisis de los datos de los entrevistados en un enfoque de investigación cualitativa. Por otra parte, ayuda a delinear las diferentes formas en que las personas conceptualizan las actitudes y el comportamiento en un ambiente geográfico delimitado del objeto de estudio. La etnometodologia facilita la interpretación y percepción de un fenómeno dado que parece entrelazado con varios otros cuando se investiga. El objetivo del presente articulo fue conceptualizar el enfoque analítico etnometodologico aplicado en la Universidad Tecnica de Manabi UTM al desarrollarse estudios bajo el enfoque cualitativa en áreas relacionadas con las ciencias humanisticas y sociales. El estudio se estableció bajo el paradigma cualitativo. El diseño fue de tipo etnografico, se aplico en la UTM con la participación de 15 estudiantes de la carrera de Trabajo Social y 5 docentes de la Facultad de Ciencias Humanisticas y Sociales. Para la recoleccion de información se estableció una entrevista semiestructurada y la revisión documental bibliográfica. Para los analisis de la información obtenida se aplico la triangulación de los resultados. Los hallazgos revelaron que, debido a la naturaleza no explícita de la etnometodología en la política curricular ecuatoriana, el fenómeno de analisis cualitativo fue concebido, conceptualizado y percibido de manera diferente por los profesores según su formación académica y profesional.
Rolling with advantage: Why Dungeons & Dragons provides new insight into the Christian concept of the imago Dei for autistic Christians
Authors: Gibbins Harry
Published: May 2023

What is clear through an exploration of disability theology is that the imago Dei is a crucial component of a proper understanding of disability and creation. Whilst the imago Dei provides excellent utility in terms of the spiritual engagement of autistic Christians, there is much to be discovered concerning new pioneering methods of approaching dialogue between autistic and non-autistic Christians. As I shall explore through an autoethnographic study drawing from my own experiences, Dungeons & Dragons is one of these pioneering methods that is a creative tool for autistic Christians. Thus, new methods emerge regarding what the imago Dei means for those on the autism spectrum.
Autism Theology: Discussions from an emerging field
Authors: Van Ommen Armand Léon , Lasch Ian , Fowler Bryan , Cundill Henna , Barber Chris
Published: May 2023

This multi-authored book review explores the current state of the field of Autism Theology through a discussion of four recent publications. A concluding section reflects on several key themes in the individual reviews, drawing particular attention to: Autism Theology's focus on the ideas and practices which enable autistic people’s thriving; the importance of the inclusion of different voices in the conversation (including those who are non- or minimally speaking); and the richness which autistic people’s presence and contributions bring to theology and to the Church as a whole.

Reviewed works:Claire Williams, Peculiar Discipleship: An Autistic Liberation Theology (London: SCM Press, 2023), pp. 272, ISBN 978-0334063063.Ruth M. Dunster, The Autism of Gxd: An Atheological Love Story (Eugene, OR: Pickwick Publications, 2022), pp. xix + 420, ISBN 978-1725268357.Stewart Rapley, Autistic Thinking in the Life of the Church (London: SCM Press, 2021), pp. xiv + 178, ISBN 978-0334060871.Cynthia Tam, Kinship in the Household of God: Towards a Practical Theology of Belonging and Spiritual Care of People with Profound Autism (Eugene, OR: Pickwick Publications, 2021), pp. x + 191, ISBN 978-1725274419.
"Religion and Worldviews: The Triumph of the Secular in Religious Education" edited by L. Philip Barnes
Authors: Robinson Leon
Published: May 2023

Review ofL. Philip Barnes, ed., Religion and Worldviews: The Triumph of the Secular in Religious Education (London: Routledge, 2023), pp. xi + 193, ISBN 978-1032206196. £22.99
Futuros do Trabalho nas Ciências Sociais: Relatório de Pesquisa
Authors: Chaguri Mariana Miggiolaro , Freitas Géssica de , Candido Marcia Rangel , Catelano Otávio Z.
Published: May 2023

Este relatório apresenta resultados da pesquisa "Futuros do trabalho nas ciências sociais". O estudo se baseou em um survey e na realização de entrevistas em profundidade com a comunidade acadêmica e teve como objetivos investigar as percepções acerca dos usos do tempo e das rotinas de trabalho acadêmico na área; conhecer percepções e expectativas de múltiplas gerações de cientistas sociais sobre a profissão; investigar desigualdades de geração, gênero e raça que atravessam a prática profissional na academia. Os resultados proporcionam um retrato abrangente de distintas gerações que integram a comunidade de trabalho acadêmico na área.
CALCULATION OF COOLING SYSTEMS FOR CVD-DIAMOND FILTERS OF THE SIBERIAN RING PHOTON SOURCE
Authors: Pukhovoy M.V. , Zolotarev K.V. , Vinokurov V.V. , Vinokurov V.A. , Finnikov K. A. , Bykovskaya Elena F. , Kabov Oleg A.
Published: May 2023

Due to high-energy density in the synchrotron beam and its potential danger due to the location of most workstation devices in a vacuum as well as high requirements for thermal deformations of optical elements, ensuring thermal management of any elements of workstations using synchrotron radiation (SR) is a unique, complex, nonstandard task. The work is devoted to optimizing the cooling of the most heat-loaded optical elements of workstations of wiggler SR sources-diamond filters and diamond windows that cut off high vacuum.
FOSTERING STEM INTEREST IN MIDDLE-SCHOOL GIRLS THROUGH COMMUNITY-EMBEDDED INTEGRATED STEM
Authors: Leammukda Felicia , Boyd Bonnie , Roehrig Gillian H.
Published: May 2023

Women are underrepresented in STEM, with the decline in attitudes among girls occurring during the middle-school years. The purpose of this study is to explore STEM interest in girls through their participation in integrated STEM in order to find ways to motivate, engage, and sustain their STEM interest. The following research question guided this study: What components of a community-embedded, integrated STEM experience promote STEM interest in middle-school girls? This single explanatory case study took place at an emerging urban STEM middle school in the midwestern United States. The entire seventh grade participated in two integrated STEM units. All seventh graders had the opportunity to participate in an additional project based on one of the two STEM units. Seven target girls were purposefully selected as participants based on their consent to complete all research requirements. This study illuminated five themes, each emerging as an important aspect of community-embedded STEM integration that may help to foster STEM interest in middle-school girls: (a) community and personal connections to helping others, (b) self-confidence and self-efficacy, (c) supportive and collaborative community, (d) student agency and choice, and (e) perseverance, persistence, and learning from failure. Findings from this study can be used to develop and guide further integrated STEM curricula that focuses on improving STEM interest, with the ultimate goal of increasing representation of women in these areas. The authors of this study challenge educators to find ways to support female success in STEM by improving their STEM interest.
Negación, solidaridad y protesta. Cambios de actitud con respecto a la muerte en tiempos de pandemia
Authors: Hoondert Martin J.M.
Published: May 2023

En este artículo se exploran las formas en que la sociedad holandesa ha afrontado la muerte desde la llegada de la pandemia COVID-19. A partir de un dossier con artículos de prensa, tuits, posts de Facebook, libros, historias en línea y entrevistas, se trazan los patrones culturales o las llamadas mentalidades en torno a la muerte. El marco teórico se basa tanto en las propuestas de Philippe Ariès como en las de Michael H. Jacobsen sobre las diferentes formas de enfrentarse a la muerte. Estos patrones culturales se refieren tanto a las ideas como a las prácticas. Una conclusión provisional es que, por un lado, existe una negación de la muerte; por otro, los cambios rituales indican una protesta contra la muerte causada por el coronavirus.
AAV capsid library production v1
Authors: Chuapoco Miguel
Published: May 2023

We recently developed adeno-associated virus (AAV) capsids to facilitate efficient and noninvasive gene transfer to the central and peripheral nervous systems. However, a detailed protocol for generating and systemically delivering novel AAV variants was not previously available. In this protocol, we describe how to produce and intravenously administer AAVs to adult mice to specifically label and/or genetically manipulate cells in the nervous system and organs, including the heart. The procedure comprises three separate stages: AAV production, intravenous delivery, and evaluation of transgene expression. The protocol spans 8 d, excluding the time required to assess gene expression, and can be readily adopted by researchers with basic molecular biology, cell culture, and animal work experience. We provide guidelines for experimental design and choice of the capsid, cargo, and viral dose appropriate for the experimental aims. The procedures outlined here are adaptable to diverse biomedical applications, from anatomical and functional mapping to gene expression, silencing, and editing.
Tissue handling for mice, marmoset, and rhesus macaques injected with AAV v1
Authors: Chuapoco Miguel
Published: May 2023

This protocol outlines all procedures for handling of tissue of animal subjects treated with AAV.
TSST v2
Authors: Bodo Heekerens Johannes
Published: May 2023

This protocol details about Trier Social Stress Test (TSST).
Surgical decision-making in the management of knee cartilage injuries in football players: Development of patient-specific recommendations using the RAND/UCLA appropriateness method v1
Authors: Filardo Giuseppe
Published: May 2023

FIFA and ICRS aim to develop, through a structured consensus method, indications on how to properly address cartilage lesions in football players. Accordingly, a consensus is planned based on the RAND/UCLA Appropriateness Method (RAM), which is used to develop patient-specific recommendations by combining the best available scientific evidence with the collective judgement of a panel of experts guided by a core panel and multidisciplinary discussers.
Immunohistochemistry v1
Authors: Chuapoco Miguel
Published: May 2023

Outlines procedures to perform immunohistochemistry on tissue that had been treated with AAV.
Fluorescence in situ hybridization (FISH) v1
Authors: Sims Peter
Published: May 2023

Fluorescence in situ hybridization (FISH) mRNA
Characterization of the VKORC1 and CYP2C9 genotypes v2
Authors: Causevic Mirsada
Published: May 2023

Vitamin K antagonists (e.g. warfarin) are anticoagulants which represent widely prescribed drugs for prevention and treatment of thromboembolic disorders. Warfarin's molecular target is vitamin K epoxide reductase enzyme and its metabolism is performed by the cytochrome P-450 2C9 enzyme, both of which are encoded by polymorphic genes - vitamin K epoxide reductase complex subunit 1 (VKORC1) and cytochrome P-450 2C9 (CYP2C9), respectively. Identification of the VKORC1 and CYP2C9 genotypes was recommended by the U.S. Food and Drug Administration in 2007, in order to guide the initial dosing of warfarin, the first oral vitamin K antagonist drug, to achieve the optimum anticoagulation and prevent hemorrhagic events. In an effort to provide a lab protocol that will provide training in pharmacogenomics/pharmacogenetics (PGx) for undergraduate students of pharmacology or medicine, that can be performed in a laboratory that contains basic molecular biology equipment and by using reagents that are available worldwide at low cost, we revisited protocols published previously by other researchers. We hope that it will provide the elementary understanding of the simplest molecular biology methods used to identify different VKORC1 (-1639G>A) and CYP2C9 genotypes, as well as understanding of a link between a specific genotype (or combination of genotypes) and phenotype relevant for a patient’s drug response. The protocol represents a step-by-step guide to using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) method in determining VKORC1 -1639G>A, CYP2C9*1/*1, CYP2C9*1/*2, CYP2C9*1/*3, and CYP2C9*2/*3 genotypes. Based on the combination of the VKORC1 -1639G>A and CYP2C9 genotypes, that is, the pattern of DNA fragments observed at the end of an experiment, which are visualized using agarose gel electrophoresis and DNA staining, a conclusion on an individual’s sensitivity to warfarin and appropriate drug dose is reached. A dataset containing the VKORC1 -1639G>A and CYP2C9 genotypes characterized in 32 patients using this protocol was deposited at the Harvard Dataverse Repository that can be accessed at the following digital object identifier: https://doi.org/10.7910/DVN/SFPYCD. In the dataset, the patients were grouped into the following anticoagulant sensitivity/dosing categories, as recommended by the U.S. Food and Drug Administration’s (FDA) label for warfarin: 1) standard anticoagulant sensitivity/dosing genotypes (N=20), 2) intermediate anticoagulant sensitivity/dosing genotypes (N=11), and 3) low anticoagulant sensitivity/dosing genotypes (N=1).
SATISFAÇÃO DOS COLABORADORES DE UMA ÓTICA SOBRE A VISÃO DO ENDOMARKETING
Authors: Timm Beatriz Ferreira , Pagan Natália Munari , Pagan Karina Munari
Published: May 2023

A satisfação no trabalho é um tema relevante que têm sido amplamente estudado. O endomarketing é uma ferramenta baseada na satisfação dos funcionários. Sabe-se que colaboradores satisfeitos em seu trabalho, atingem maiores níveis de eficiência, produtividade, comprometimento e rendimento. Este estudo teve como objetivo analisar os fatores que influenciam na satisfação no trabalho dos colaboradores de uma Ótica localizada em Santo André (SP). Foram analisados a satisfação dos colaboradores com os colegas, com o salário, com a chefia, com a natureza do trabalho e com as promoções. Para tanto, realizou-se uma pesquisa de caráter qualitativo (estudo de caso) e como instrumento foi utilizado a entrevista semiestruturada. A população alvo do estudo foi todos os colaboradores da ótica (5 funcionários). Para montar as perguntas da entrevista, foi utilizado cinco dimensões que constam na literatura: salário, colegas, chefia, promoções e o próprio trabalho. A entrevista foi realizada por telefone, em melhor dia e horário para o entrevistado, o objetivo foi garantir o sigilo da pesquisa e o conforto para o entrevistado e foi aprovada pelo Comitê de Ética. Para a análise dos dados, foi utilizado a triangulação do estudo de caso: comparação das respostas obtidas de acordo com as cinco dimensões analisadas. Os resultados demonstraram que os cinco colaboradores estão satisfeitos com as cinco dimensões analisadas nesta pesquisa
Sobre a “nação” e o impacto da etnologia nas reflexões de Marx e Engels
Authors: Chagas Rodrigo Chagas
Published: May 2023

Recebido: 10/04/2023

Aprovado: 25/04/2023

Realizamos uma investigação sobre o termo nação na Marx/Engels Collected Works (MECW), com o objetivo de compreender as variações nas reflexões dos autores sobre os temas “nação” e “nacionalismo” ao longo do tempo. Durante o processo de pesquisa, ficou evidente o impacto dos estudos etnográficos, que ganharam força no final da década de 1860, sobre a perspectiva de Marx e Engels. Destaca-se, neste sentido, a inversão de valores que os pensadores alemães realizaram na dicotomia ocidental “civilização e barbárie”, além da afirmação de uma dimensão positiva do “comunismo primitivo”.
Entre Canções e Desilusões:
Authors: Porto Apenburg Trindade Mônica
Published: May 2023

Recebido: 12/03/2023

Aprovado: 02/04/2023

O presente trabalho busca examinar como a Guerra do Vietnã apareceu em algumas canções de rock lançadas durante a década de 1970, por bandas norte-americanas e inglesas. Através dessas canções, almeja-se verificar qual foi o tipo de abordagem conferida ao conflito e como esses artistas refletiram o contexto vivido, exibindo-o mediante a composição das letras e por intermédio da arte exposta nas capas dos álbuns que abrigavam tais canções. Não obstante uma época marcada pelo sentimento de desilusão, pensar na relação entre rock e Guerra do Vietnã nos anos 70 é procurar compreender em que medida e de que maneira esse evento impactou o cotidiano tanto na sociedade estadunidense, quanto na sociedade britânica.
ausência paterna e as repercussões no desenvolvimento do adolescente
Authors: Pinto Souza Julio Cesar , Souza Bezerra Fabiana
Published: May 2023

Recebido: 13/12/2021

Aprovado: 15/06/2022

A figura paterna é a responsável por ajudar a criança a desenvolver sua personalidade e habilidades sociais desde os primeiros momentos de vida, estendendo-se até o final da adolescência. A ausência da figura do pai pode gerar sofrimento, incertezas e perda de referência, levando o indivíduo em desenvolvimento a apresentar transtornos psíquicos e de personalidade. A presente pesquisa teve como objetivo investigar os efeitos causados pela ausência paterna no desenvolvimento de adolescentes crescidos sem a presença da figura paterna. A pesquisa teve uma abordagem quantitativo-qualitativa e caráter descritivo e como instrumento foi utilizado um questionário. Os resultados comprovam que a ausência da figura paterna pode repercutir na vida do indivíduo e na adolescência com mudanças de comportamentos e conteúdos distorcidos, refletindo no convívio em sociedade através de sentimentos de desvalorização, vazio, insegurança, dificuldades de relacionamento, além de agressividade e mau desempenho escolar.
An overview of the monkeypox
Authors: Chaurasiya Raunakkumar , Kamble Jayalalita , Kumar Yeshwant , Giri Rambishwash , Chaudhary Dhiraj , Singh Rahul , Kharsyntiew Cruciforth
Published: May 2023

Smallpox-like symptoms are caused by the human monkeypox orthopoxvirus, a zoonotic orthopoxvirus. The zoonotic human monkeypox was detected in 1970, twelve years after the monkeypox virus was found in a Danish lab in 1958. It has lately been documented in cases outside of Africa, and it has spread to other regions of Africa. (mainly West and Central Africa). The genesis, epidemiology, and ecology of the disease are still largely unknown, which has caused a rise in the frequency and geographic dispersion of human monkeypox cases in recent years. 8 days on average were needed for incubation. (range 4–14 days). A multi-nation outbreak of human monkeypox infections, involving transmission from person to person, was documented in Europe and North America in May 2022. Monitoring and epidemiological analysis need to be more precise in order to calculate the effect on public health and develop policies to reduce the risk of a larger spread of disease. Small viral epidemics with mortality rates around 10% and rates of secondary human-to-human transmission around the same percentage are frequent in tropical Central and West Africa. On July 31, 2022, the first case of monkeypox mortality was reported in India; the victim was a 22-year-old man who had recently returned from the United Arab Emirates. In light of the continuous outbreaks throughout the world, we provide current information on monkeypox for medical professionals in this overview. There is a zoonotic orthopoxvirus that produces human monkeypox. However, ST 246 has been found to be effective in vivo and in vitro in infected animals, and experiments were safely carried out on non-infected humans. ST 246 has not been tested for its effectiveness on monkey pox or orthopox-infected individuals.
Correlation of oral mucosal lesions with various habits and histopathological findings
Authors: Shah Nirali , Kumar Kalpana Rajiv
Published: May 2023

The oral mucosa is subjected to numerous local irritants throughout the life. This makes the oral cavity one of the most common sites for various benign, premalignant and malignant lesions. These lesions can cause variety of symptoms, leading to severe discomfort in daily life. Oral lesions generally present in the form of ulcer, swelling, discolouration or restricted mouth opening. Hence, the knowledge of all these pathological lesions of oral cavity becomes important in their early diagnosis and effective management. In our current analytical and descriptive study, we studied clinical profile and histopathologic findings of various oral mucosal lesions, in 80 subjects. These lesions were found to be more common in middle aged males of low socioeconomic status. There was strong association between tobacco chewing and smoking with occurrence of premalignant and malignant lesions. Alcohol addiction often coexisted with tobacco consumption; and was found to be weakly associated with only malignant lesions. Aphthous stomatitis and Oral submucous fibrosis were found to be the most common benign and premalignant lesions, respectively. Most common malignant lesion was squamous cell carcinoma of buccal mucosa. History and clinical examination were needed to study the type, site, gross appearance and extent of the lesion. However intra-oral biopsy was gold standard in making accurate diagnosis of these lesions. Knowledge obtained through this clinico-histopathological study was useful to make early diagnosis of oral mucosal lesions for their effective management.
A rare presentation of recurrent tongue tie
Authors: Shetty Rohan , Tanthry Deepalakshmi , Tanthry Gururaj
Published: May 2023

Ankyloglossia or tongue-tie is the result of a short, tight, lingual frenulum causing difficulty in speech articulation due to limitation in tongue movement. Ankyloglossia is a common finding in infants. Prevalence ranges between 4.2% and 10.7%. Although lingual frenectomy is a common technique it is a sensitive surgical procedure, the anatomic and topographic lingual frenulum makes the site vulnerable to various intraoperative and postoperative complications. In this case study, we have reported a 2-year-old male child with prior history of a frenectomy, presented with difficulty in speech and restricted tongue movements. On examination, a 1x1cm, solitary swelling was noted in the region of the lingual frenulum, firm, cystic, and non-tender. Tongue movements were restricted with an inability to perform protrusion beyond the vermillion border of the lips.Under general anesthesia, the child underwent revision frenectomy, excision of the swelling, and release of fibrous tissue adjacent to the swelling .Intraoperatively protrusion of the tongue was examined and found to have improved .The specimen was sent for histopathology which was reported as organizing mucocele. The Child was reviewed after 6 months, tongue movements were seen to have improved substantially in all ranges of motion.
Diseños institucionales para mejorar el desempeño de la infraestructura desde la óptica de transparencia e integridad
Authors: Gambier Beltrán
Published: May 2023

Este informe ofrece un análisis de un nuevo modelo de institución supervisora de la gestión de las infraestructuras conocido como iBodies, por su sigla en inglés. La experiencia en aquellos países que poseen iBodies muestra que pueden tener un importante impacto en la promoción de prácticas de integridad, buena gobernanza y transparencia en este sector. Los iBodies también aumentan la probabilidad de que el gasto público en infraestructuras sea realizado siguiendo los mejores estándares internacionales de calidad institucional, y reducen significativamente la posibilidad de comportamientos indebidos. El presente trabajo analiza los iBodies de Nueva Zelanda, Australia y Reino Unido. Asimismo, también se analiza el caso de Canadá que, si bien aún no ha desarrollado su iBody, tiene intención de hacerlo siguiendo las mejores prácticas internacionales. Los países que cuentan con este tipo de entes públicos además muestran buenos resultados en aquellos indicadores que miden calidad de las instituciones, integridad del sector público y respeto por el estado de derecho, conforme a los índices internacionales más confiables.
Implementación de inteligencia artificial para mejorar la atención de la retinopatía diabética en el Estado de Jalisco, México
Authors: Tejerina Luis , Perez-Cuevas Ricardo
Published: May 2023

El presente documento presenta un estudio de caso de un proyecto piloto en el estado de Jalisco que utilizó inteligencia artificial (IA) para el tamizaje de la Retinopatía Diabética. El resultado fue el proyecto RETINA-IA, que incluyó una convocatoria activa de pacientes potenciales; la toma de fotografías de la retina en tres clínicas seleccionadas y su interpretación utilizando tecnología IA de deep learning; coordinación con un equipo del Colegio Médico de Oftalmólogos de Jalisco para verificar el pre-diagnóstico realizado por la IA; y la referencia de los pacientes que lo requiriesen a una cita con un especialista. Con el uso de IA se logró prediagnosticar y referir pacientes en 1 a 2 días. Además, el algoritmo tuvo un buen desempeño en términos de la clasificación correcta de cada nivel de retinopatía.
Editorial
Authors: Souto Tatiane Beltramini
Published: May 2023

Segue editorial Volume 8 edição 2021
Association of the Thyroid Nodules' Sonographic Features With Fine Needle Aspiration (FNA) Cytology Results
Authors: Ghanaati Hossein , Arefzadeh Alireza , Hosseinpour Hamidreza , Avanaki Mahsa Alborzi , Abrishami Alireza , Jalali Amir Hossein
Published: May 2023

Thyroid nodules are a common finding in clinical practice. Although ultrasonography is an accepted method for evaluating these nodules, Fine Needle Aspiration (FNA) is the procedure of choice for assessing the risk of malignancy. This study aims to determine the association between sonographic features of thyroid nodules based on Thyroid Imaging Reporting and Data System classification and the cytology results. In this prospective cohort study, 147 patients from Tehran Medical Imaging Center who had thyroid nodules underwent ultrasonography-guided FNA, and their sonographic features were recorded. The pathologic findings were also obtained according to the Bethesda system. Finally, the association between sonographic features and cytological results was analyzed. Eighteen (12.3%) nodules were malignant, and 129 nodules (87.7%) were benign. The association of TIRADS categories with the risk of malignancy is as follows: TIRADS 1 (n=0, 0%), TIRADS 2 (n=10, 16.9%), TIRADS 3 (n=6, 10.5%), TIRADS 4 (n=2, 16.7%), and TIRADS 5 (n=0, 0%). The bloody lamellae of thyroid nodules were significantly correlated with the risk of malignancy (P<0.05). However, there was no statistically significant association between the risk of malignancy and gender (P=0.47), calcification (P=0.9), firmness (P=0.19), halo sign (P=0.95), location of nodules (P=0.35), and nodules' echogenicity (P=0.058). Although there are trusted classifications such as TIRADS for categorizing thyroid nodules, there is still uncertainty in utilizing them, especially in the management of nodules classified as TIRADS 2, in which various sonographic features are shared between benign and malignant nodules.
Evaluation and Comparison of Two Different Combined Regimens for Prophylaxis of Nausea and Vomiting After Laparoscopic Bariatric Surgery: A Double-Blinded Randomized Clinical Trial
Authors: Shahinpour Shervin , Momeni Niusha , Yaqubnejad Mahdi , Khajavi Mohammadreza , Pourfakhr Pejman
Published: May 2023

Postoperative Nausea and vomiting (PONV) are the most complications after laparoscopic surgeries, especially laparoscopic bariatric surgeries. The incidence of PONV has been estimated in over two-thirds of patients undergoing laparoscopic bariatric surgeries. Prophylactic combined antiemetic therapy is recommended for patients undergoing these surgeries. This is a double-blinded randomized clinical trial. Eighty-three patients of ASA physical status I and II undergoing elective bariatric laparoscopic surgery were enrolled in this clinical trial and divided into two equal groups through simple randomization using a random number table. One group (group A) received a combination of ondansetron, dexamethasone, and haloperidol (ODH); and the other group (group B) received a combination of ondansetron, dexamethasone, and promethazine (ODP). The ODP group received promethazine 25 mg IM 30 minutes before extubation and ODH group received haloperidol 2 mg IM at the beginning of the surgery. Nausea and vomiting were assessed in terms of severity and frequency in the recovery room, 6, and 24 hours postoperatively in both groups using the Numeric Verbal Rating Scale (NVRS). The frequency of PONV was significantly lower in the ODH group compared to the ODP group in the recovery room (20% versus 40%). PONV severity was lower in the ODH group compared to the ODP group. The time to first rescue antiemetic prescription in the ODP group was more than in the ODH group (7.2 h versus 2.6 h). In morbidly obese patients undergoing laparoscopic bariatric surgery, both antiemetic combinations decreased the incidence of PONV, but the combination of haloperidol, dexamethasone, and ondansetron was more effective than promethazine, dexamethasone, and ondansetron.
A Large Parapharyngeal Mass in A Five-Year-Old Girl: A Case Report
Authors: Aghazadeh Kayvan , Azimzade Khosravi Reza Erfanian , Heidari Farrokh , Sodagari Nasim , Karvanian Sepideh , Rahmaty Benyamin
Published: May 2023

Lesions in the parapharyngeal space are rare and account for 0.5-1.5% of all head and neck tumours. Of these, venous malformations represent 1% of all parapharyngeal space tumors. In the current paper, we reported a 5-year-old patient who presented with a soft tissue swelling of the parapharyngeal space that was discovered by her parents after two weeks following adenoidectomy. The MRI revealed a tumour within the parapharyngeal space with a well-defined mass with low-signal intensity on T1 and high on T2. The internal flow voids also proposed phleboliths. Therefore, the tumour was removed by an intraoral approach. The post-op pathology result explicated a venous malformation.
Ante-, Peri-, and Neonatal Factors Associated with Autism Spectrum Disorders in Vietnam: A Population-Based Cross-Sectional Survey
Authors: Vui Le Thi , Duc Duong Minh , Quynh Chu Thi Thuy , Kim Tuan Duong , Huong Nguyen Mai , Thanh Nguyen Thi Minh , Minh Hoang Van , Ha Bui Thi Thu
Published: May 2023

Background: Autism Spectrum Disorders (ASDs) are common behavioral syndromes but limited critical evidence in Vietnam. This study aimed to identify ante-, peri- and neonatal factors for ASDs amongst children in Vietnam.
Methods: This population-based study applied the cross-sectional design with a multistage sampling in 21 urban and rural districts in seven cities/provinces in Vietnam during 2017-2018. Overall, 42,551 children age 18 to 30 months were enrolled in the study. Two phases of assessment using Modified Checklist for Autism in Toddlers (M-CHAT) for screening and diagnostic assessment using Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) criteria for confirmation. We employed univariate and binary logistic regression to identify.
Results: Our study showed a fast-growing trend of ASDs amongst children age 18 and 30 months (75.8 per 10,000 individuals). Nine ante-, peri-, and neonatal factors were associated with ASDs: five factors of antenatal period (history of miscarriage/abortion or stillbirth, children conceived by assisted reproduction technologies, having cold, flu or acquiring virus during pregnancy, having gestational diabetes, toxemia, high blood pressure or pre-eclampsia during pregnancy, and having stress or mental disorders during pregnancy); one factors of perinatal period (mode of delivery); and three factors of neonatal period (jaundice, respiratory distress, and newborn seizures)
Conclusion: This first large-scale survey in Vietnam confirms some prenatal, perinatal, and postnatal factors with ASDs amongst children age 18 and 30 months. Future interventions should focus on these factors to early diagnosis and intervention to improve functional outcomes for risky children.