bluuebunny/crossref_metadata_2025 huggingface dataset:
MicroRNA-484 / Akt axis in the regulation of breast cancer cells sensitivity to antitumor drugs
Authors: Andreeva O. E. , Sorokin D. V. , Scherbakov A. M. , Shchegolev Y. Y. , Gudkova M. V. , Krasil’nikov M. A.
Published: December 2022

The development of acquired resistance of malignant tumors to specific drugs, such as target and hormonal drugs, is usually associated with a rearrangement of the intracellular signaling network and activation of unblocked growth pathways. Epigenetic regulators, in particular, non-coding miRNAs that control the level of expression of specific signaling proteins, are directly involved in the development and maintenance of such changes. We have previously shown that the development of resistance of breast cancer cells to mTOR (mammalian target of rapamycin) inhibitors and hormonal drugs is accompanied by constitutive activation of protein kinase Akt, the key anti-apoptotic protein.Aim. To study the role of microRNAs in the regulation of Akt expression and the formation of a resistant phenotype of breast cancer cells.We have shown that Akt activation in the tamoxifen- or rapamycin-resistant MCF-7 sublines is associated with a decrease in the level of miRNA-484, one of the Akt suppressors. Transfection of microRNA-484 into MCF-7 cells does not affect the activity of estrogen signaling, but leads to a marked decrease in Akt expression and is accompanied by an increase in cell sensitivity to tamoxifen and rapamycin. The obtained data demonstrate the involvement of the miRNA-484 / Akt axis in the breast cancer cells’ sensitization to target and hormonal drugs, which allows us to consider miRNA-484 as a potential candidate for drug development to cure resistant cancers.
Autophagy activation in breast cancer cells in vitro after the treatment with PI3K/AKT/mTOR inhibitors
Authors: Grigoreva D. D. , Zhidkova E. M. , Lylova E. S. , Enikeev A. D. , Kirsanov K. I. , Belitsky G. A. , Yakubovskaya M. G. , Lesovaya E. A.
Published: December 2022

Introduction. Current chemotherapy of breast cancer has a wide range of disadvantages, in particular, the development of therapy-related infections and hormonal imbalance. Combination of main cytostatic with glucocorticoids allows to broaden its therapeutic interval and to decrease the total toxicity of the treatment. However, long-term treatment with glucocorticoids leads to the development of severe side effects via activation of multiple molecular mechanisms. Thus, glucocorticoids activate prosurvival mTOR-dependent autophagy. Therefore, the evaluation of PI3K (phosphoinositide 3-kinases) / Akt (protein kinase B) / mTOR (mammalian target of rapamycin) inhibitors as adjuvants for breast cancer therapy is important for optimization of treatment protocol.Aim. Analysis of the effects of PI3K/Akt/mTOR inhibitors, rapamycin, wortmannin and LY-294002 in combination with glucocorticoids in breast cancer cell lines of different subtypes.Materials and methods. We demonstrated the inhibition of PI3K/Akt/mTOR signaling and the autophagy induction after the treatment of breast cancer cells with rapamycin, wortmannin and LY-294002 by Western blotting analysis of Beclin-1, phospho-Beclin-1 (Ser93 and Ser30).Conclusion. PI3K/Akt/mTOR inhibitors in combination with Dexamethasone cooperatively inhibited mTOR signaling and activated autophagy in breast cancer cells in vitro.
Assessment of the functional movement screen and injuries in gymnasts
Authors: Vernetta-Santana Mercedes , Salas-Morillas Alicia , López-Bedoya Jesús
Published: December 2022

Objective: To identify possible differences in movement quality through the functional movement screen (FMS) between injured and non-injured adolescent acrobatic gymnasts in the last season. Method: descriptive, comparative, cross-sectional study involving 20 adolescent female gymnasts divided into two groups, one composed of 9 gymnasts who had suffered an injury in the last season (14,7±1,56) and the other composed of 11 gymnasts who had not suffered any injury (13,9±2,25). The FMS battery was used, consisting of seven tests: deep squat, hurdle step, in-line lunge, shoulder mobility, active straight leg raise, trunk stability in push-ups, trunk rotational stability. Results: Of the nine gymnasts who had sustained an injury, 66.6% were located in the lower limb, ankles and knees. The results of the total functional assessment of FMS using the Mann Whitney U statistic for independent samples showed no statistically significant differences between groups (Z = -.393; p > 0.05), with the average range of FMS being similar in both cases (10.05 and 11.06 in injured and non-injured gymnasts respectively). It also showed the absence of significant differences in each of the tests of the battery, and no relationship was found through Spearman’s R statistic, between the overall FMS score and the group of injured gymnasts. Conclusion: The results of the FMS total score were slightly higher in gymnasts who were not injured last season, as well as slightly better in all the lower body tests, hence the FMS can be used as a preventive programmed to detect possible deficiencies.
Electro-echocardiographic correlation in high-performance athletes
Authors: Marigo Claudio M. , Vozzi Carlos R. , Vozzi Lara , Pezzotto Stella M
Published: December 2022

Background: Functional and structural cardiac adaptations are generated by sustained physical training. The objective of our investigation was to evaluate the association in electrocardiographic and echocardiographic findings in a population of high-performance athletes. Material and method: 30 male athletes (10 water polo players, 10 triathlonists and 10 swimmers), ages 18 to 40 years old, training 20 to 30 hours per week for at least one year, were evaluated. Clinical, electrocardiographic (ECG) and echocardiographic examination was performed on each of them at Instituto Vozzi. Results: Echocardiographic results showed that the mean septal thickness, the mass index of the left ventricle (LV), the anteroposterior diameter and the area of the left atrium (LA), the area of the right atrium (RA) and the base of the right ventricle (RV) were found above normal values for the general population. None of the athletes ECGs presented LA, RA or RV enlargement. Nine of 30 (30%) presented signs of LV enlargement. After adjusting for age, weight, height, body surface area, and sport performed, LV diastolic diameter (LVDD) indexed to body surface area (BSA) was higher in athletes with LV enlargement on ECG (adjusted mean 28.94 ± 0.56 mm; 95% CI = 27.78-30.10) vs without (27.67 ± 0.36 mm; 95% CI = 26.93-28.41). More triathlonists presented LV enlargement signs on the ECG compared to the other groups. Conclusions: Certain echocardiographic parameters in our population of athletes are above normal values for the general population. There was no relationship comparing electrocardiographic and echocardiographic signs of LA, RA and RV enlargement. An association was found between ECGs LV enlargement and increased LVDD indexed to BSA on the echocardiograms. LV enlargement on the ECGs was more frequent in the triathlon group.
Mesin Ayak Dua Saluran Dilengkapi Pengarah untuk Produk Beras Jagung
Authors: Yokasing Yohanes B , Abdullah Amiruddin , Tamelab Stanislaus
Published: December 2022

A sieve machine is used to separate groups of granules based on size. Most separation sieves on two groups of sifted/filtered grains move immediately, but the unfiltered grains are removed by the operator turning the sieve sideways or lifting the unfiltered material. In addition, the sifted material is usually poured directly on the sieve wire. This slows the sifting process, and the buildup can damage the sieve. On the other hand, sieve materials, such as corn rice products, require two sizes of sieve wire holes. Design, make, and study the function, "The Sieve Machine's two-channel Equipped with Directions for Rice Corn". The specification of the sieve machine is as follows; it has two sifting channels, the sieve filter can be replaced, a swing arm drives the filter, the dynamo operates on 3/4 hp, rotation 1400 rpm, the capacity for one stage is ± 44.8 kg/hour, the capacity for corn rice ± 22 kg/hour (it's time to change the sieve). The study of engine performance on several variables showed that the smaller the lightening angle, the capacity increases; it is inversely proportional to the length of the spring and rotation. At angle 50 sieve capacity is 23.3 kg/hour, with the length of the spring being 90.5 mm, and on the size of the spring becoming 100.5 mm, the sieva capacity of 24.6 kg/hour. For angle 150, the capacity is reduced by 20.4 kg/hour. At rotation 230 rpm, 50 angles, decreased capacity, only 20.3 kg/hour, spring length 90.5 mm
Pengaruh Pengetahuan, Pengawasan dan Kelengkapan Sarana Pengelolaan Sampah Awak Kapal terhadap Perilaku Pencegahan Pencemaran Laut di Pelabuhan
Authors: Nursyamsu Nursyamsu , Putra Ade Mardani , Dewi Astri Kustina , Sutryani Henni
Published: December 2022

In Indonesia, marine pollution is a common problem. Ship personnel operating in ports often contribute to marine pollution. This study aimed to determine the impact of crew behavior in relation to the prevention of marine pollution on their knowledge, supervision, and completeness of their waste management facilities. The methodology of this research is quantitative. With the help of SmartPLS version 3.0, the analysis used in this work takes a structural approach to the Equation Model. A total of fifty crew members who participated in the study were randomly selected from the pool of participants. In addition, participants in this study were randomly selected by distributing questionnaires to the crew at Merak Harbor. According to research findings, the behavior of seafarers in preventing marine pollution in ports is influenced by their knowledge, supervision, and quality of infrastructure.
Risk Assessment Kesehatan dan Keselamatan Kerja (K3) pada Pekerjaan Bongkar Menggunakan Metode Hazard Identification, Risk Assessment, & Risk Control pada Pelabuhan Ciwandan di Banten
Authors: Magdalena Susiarni , Mansur Harri Mochamad , Kurniasari Dwi Endah , Miharja Jaja
Published: December 2022

Unloading work at the port has a high risk. Thus, Occupational Health and Safety (K3) through risk assessment must always be considered so that it meets K3 standards so that the risk of work accidents can be reduced. This study aims to conduct a K3 risk assessment on unloading work using the HIRARC (hazard identification risk assessment control) method at the Ciwandan Port in Banten. This exploration is an assessment that concentrates on using a subjective methodology with the stages of a basic review, problem planning, and examination objectives, sharing information, managing HIRARC data, investigating the report, and making conclusions. The consequence of this study shows that the risk rating that can be identified is at least 2 Low, 7 High, and 8 Emergency from the aspect of working environment conditions, activities, and mental conditions of Ciwanden Banten Port workers. So it can be concluded that there are aspects of K3 that have a high risk and require higher attention. Therefore, further research is needed regarding risk control that can be provided based on a risk assessment from the word related to the Health and Safety (K3) technique HIRARC (Hazard Identification, Risk Assessment, and Risk Control) at the Port of Ciwandan in Banten.
Analisis Pengujian Tarik dan Sebaran unsur pada Pengelasan Aluminium – Mild Steel menggunakan Metode Cold Metal
Authors: Prabandono Bayu , Kartika Santosa Agnes Putri , Ardani Devinta Putri , Kurniawan Agus , Yusuf Mirza
Published: December 2022

The technology that has been developed in recent years is the production of fusion welded plates between two different materials, for example, steel with other materials such as aluminum. Combining the two materials, aluminum and mild steel, will undoubtedly produce a material connection with good properties, for example, in a vehicle car frame. However, these two materials have different melting points, mild steel has a high melting point, and aluminum has a low melting point in the inner layer. This research aims to determine the welding results and the microstructure between aluminum plates and mild steel. The Cold Metal Transfer (CMT) welding process provides a potential method for joining dissimilar metals. In this study, various 4 mm thick aluminum alloys (Al 1100) were joined to 4 mm thick mild steel (SPHC) by CMT welding technology. It was concluded that combining aluminum alloys with mild steel using the cold metal transfer method was feasible. The optimum process variable for welding aluminum-mild steel dimensions 250 mm × 100 mm × 4 mm can be obtained with ER70S-6 wire, ArCO2 shielding gas, wire feed speed 13 m/min, and welding speed e8 mm/s.The tensile strength of the joint first increases and then decreases as the welding current increases, the highest tensile strength can reach 73.35 MPa.
Sengketa Sertipikat Ganda Akibat Perbuatan Melawan Hukum
Authors: Ariansyah Muhammad Daffa , Anggriani Reni
Published: December 2022

Legal certainty for land ownership in the form of a certificate has been regulated in Government Regulation Number 24 of 1997 jo. Government Regulation Number 18 of 2021, but not all certificates provide legal certainty, as in civil case No. 282/PDT.G/2020/PN SMG, namely land ownership disputes, namely the existence of multiple certificates of land rights on the same plot of land. The research is to find out how legal protection is related to legal certainty for holders of proof of ownership of land rights based on Government Regulation Number 24 of 1997 jo. PP Number 18 of 2021 concerning Land Registration by disclosing facts according to the conditions and realities that exist in society. The method used is normative. Legal certainty regarding land ownership is evidenced by a certificate that has been made in accordance with applicable procedures. The inhibiting factor for the government in the land registration process so that the products issued do not cause administrative defects is the existence of socialization from the government, in this case ATR/BPN, for all processes and documents that need to be considered in the land registration process.
Pengaruh Sudut Kampuh V Tunggal terhadap Sifat Mekanis Sambungan Las SMAW pada Pipa Baja Karbon API 5L X46
Authors: Nugroho Aris Widyo , Hartanto Sigit , Nugroho Muhammad Arinalhaq Eko , Himarosa Rela Adi
Published: December 2022

Penelitian untuk mengetahui pengaruh sudut kampuh V pengelasan SMAW terhadap sifat mekanis sambungan las pada material pipa API 5L X46 telah dilakukan. Proses pengelasan dilakukan dengan sambungan butt-joint kampuh V tunggal menggunakan material pipa API 1104 5L grade X46 dengan tebal pipa 12,7 mm. Sudut kampuh yang digunakan adalah 45º, 50º, 55º, 60º, 65º, 70º, dan 75º. Sambungan lasan kemudian dilakukan beberapa pengujian meliputi inspeksi visual, uji NDT RI, uji metalografi menggunakan standar ASTM E340-15, uji kekerasan menggunakan standar ASTM E92-82, dan uji bending menggunakan standar API 1104. Hasil penelitian menunjukkan bahwa semakin besar sudut kampuh las maka heat input dan waktu proses semakin besar. Secara umum kekerasan HAZ dan WM meningkat seiring dengan peningkatan sudut kampuh. Nilai kekerasan sebesar 135,73 VHN pada HAZ, dan 146,19 VHN pada WM diperoleh pada sudut kampuh 75o. Tegangan bending maksimum pada root bend dan side bend test meningkat seiring dengan kenaikan sudut kampuh dan berturut-turut tercapai pada variasi sudut kampuh 60º sebesar 5.685 MPa dan 4.222 MPa, kemudian tegangan lentur menurun bila sudut kampuh membesar. Sudut kampuh 60o merupakan sudut kampuh optimal dari segi sifat mekanis sambungan dan produktifitas proses pengelasan.
Concepções e perspectivas da Plataforma Nilo Peçanha: regulação e emancipação
Authors: Prado Di Paula Ferreira , Brito Vera Lúcia Fernandes de , Nunes Claudio Pinto
Published: December 2022

Este artigo analisa a implantação da Plataforma Nilo Peçanha e suas implicações para a Rede Federal de Educação, considerando o contexto de efetivação das políticas de avaliação, monitoramento e controle, fundamentadas no uso de indicadores de gestão baseados apenas em resultados mensuráveis, que podem se tornar mecanismos de controle para a manutenção de determinada ordem social. A pesquisa é qualitativa, em uma abordagem descritiva exploratória, articulada a uma pesquisa bibliográfica e documental. O estudo indica que os sistemas de avaliação podem constituir, de um lado, um mecanismo de controle e regulação e, de outro lado, instrumento de emancipação, a depender dos princípios que norteiam a análise e a aplicação dos resultados que subsidiarão as novas políticas públicas educacionais.
Parental consanguinity a possible risk factor for tooth agenesis: A case series
Authors: Siddiqui Maryam , Juneja Akanksha , Sultan Amina
Published: December 2022

Dental agenesis is a commonly encountered dental anomaly that affects more than 20% of the human population. It can be categorized as hypodontia, oligodontia, or anodontia. Oligodontia can occur either as an isolated finding or as a part of the syndrome, and the causative factor can be either environmental or genetic.

: This report describes three cases of isolated, non-syndromic tooth agenesis with single/ multiple missing permanent teeth. No other associated clinical features or any systemic involvement were present in these cases, suggesting parental consanguinity as a possible etiological factor.

: The purpose of this case report is to promulgate premarital counselling and health awareness programs focusing on the potential consequences of consanguineous marriages and their prevention.
An interim feeding prosthesis for newborn patient with cleft palate: A case report
Authors: Kumar Surender
Published: December 2022

Cleft palate and lips are the most common congenital anomalies affecting the new born. It can occur isolated or together in various combination and/or along with other congenital deformities. Most common difficulty occur due to this type of anomalies in newborn children’s are difficulty while feeding, which occur because of complete absence of oral seal required during sucking of milk. Early surgical intervention can’t be given to such patient till the age of 6 months till that time these patient are treated with interim types of feeding appliances. This case report present a 2-month-old neonate born with cleft palate, assisted with new feeding appliance made of polymathy methacrylate polymer (PMMA).
IV International Conference "Artificial Societies and Information Technologies"
Authors: Konkova Tatiana
Published: December 2022

On September 27, 2022, IV International Conference "Artificial Societies and Information Technologies" was held on the basis of the Central Economics and Mathematics Institute of the Russian Academy of Sciences. And on September 28 a round-table  discussion "Supercomputer Technologies and Artificial Societies" was held
Modern Software tools for Agent-based modeling
Authors: Bragin Alexey
Published: December 2022

The article describes the current state of the industry of software tools for creating agent-based models, conducting agent-based simulation and processing the results of such modeling. Despite the large number of articles on various problems in the field of agent-based modeling and reviews of some software tools, only one comprehensive English-language work on this issue was published in 2017. Publications in recent years do not fully reflect the state of the industry, there are practically no reviews in Russian. This work is devoted to a review of agent-based and simulation modeling tools with a brief description of them.
Prototype of Simulation model of Socio-epidemiological and economic consequences on the example of Russian Federation subjects
Authors: Evdokimov Dmitry
Published: December 2022

Processes associated with extraordinary events that are difficult to control and evaluate, as a rule, are built on patterns of past events or historical analogues, but the spread of coronavirus infection is a kind of unique phenomenon that has affected all spheres of life of states and the world as a whole.
This article is a continuation of a study related to the assessment of the socio-epidemiological and economic consequences that led to the spread of COVID-19. Previously, the architecture of the model was created taking into account world practices for building such blocks for simulation models. The prototype combines three fully functional blocks. At this stage of the study, a prototype model was formed, which takes into account demographic, epidemiological and economic processes that are closely related to each other. The simulation has been running continuously since 2018 and covers three chronological periods - before the pandemic, during the pandemic and the forecast period. The experiment ends in 2025, after which a set of statistical indicators is produced for the three aligned blocks. The prototype model has prospects for expansion to all subjects of the Russian Federation. Also, if you add a loading module, it can be launched using supercomputer technologies on a scale of 1: 1 in terms of the number of agents that form an artificial society on the basis of which scenario experiments were carried out.
Ofrenda: morir bien y en coexistencia
Authors: Aldazabal Irene
Published: December 2022

Ofrenda fue una acción ritual y sitio-específico que implicó la recolección colectiva de plantas, la construcción de cuencos escultóricos y su entrega al Nahuel Huapi.  Mediante recuerdos, conceptos teóricos y especulaciones, este ensayo indaga  nociones de coexistencia, cuidado y corporalidad, en torno a esta obra que, ligada a mi experiencia de acompañamiento a mi abuela en sus últimos meses de vida, es una reflexión sobre procesos de vida y muerte como una Ofrenda para ella y para la tierra.
“Combatir la tiranía y controlar el poder”. Los usos políticos de la libertad de imprenta en Nueva Granada y Colombia (1810-1830)
Authors: Martínez-Martín Abel Fernando , Otálora-Cascante Andrés Ricardo
Published: December 2022

Este artículo relata la celebración del centenario de la batalla de Boyacá en 1919 en la ciudad de Tunja, Colombia. La capital de Boyacá culminaba una década de Fiesta Nacional y reforma urbana en donde aparecieron parques, plazas, avenidas y monumentos en honor a los héroes de la Independencia, que complementaron los hitos coloniales de la ciudad. A pesar de las dificultades presupuestales y las obras inconclusas, las fuentes de archivo muestran que el gobierno nacional de la Hegemonía Conservadora y la Iglesia católica urdieron en la trama urbana de Tunja el discurso de la independencia y su tradición hispánica para dar la imagen de una comunidad nacional unida, católica y en paz, encaminada hacia el progreso. Las contradicciones y problemas de esta celebración pusieron en evidencia la existencia de fisuras en la Comunidad Imaginada de esta “república celestial”.
Extractivismo, acero y ambiente: Acerías Paz del Río y el auge industrial en el Valle de Sogamoso, Boyacá (1954-1983)
Authors: Huérfano-Aguilar Sebastián
Published: December 2022

En septiembre de 1954, Acerías Paz del Río inició la producción industrial de acero en el Valle de Sogamoso (Boyacá), un altiplano colombiano sobre los 2.500 metros de altura. La industria siderúrgica se instaló en este altiplano luego del descubrimiento de extensos y aprovechables yacimientos de hierro y carbón en las cercanías, en la población de Paz de Río y Socha (Boyacá). La explotación de materiales y la producción de acero transformaron a una región eminentemente rural, dedicada a las actividades agropecuarias, en el centro siderúrgico y minero de Colombia. Durante este auge productivo entre 1954 y 1983, el artículo indaga cuál fue el impacto social, productivo y ecológico de Acerías Paz del Río, la industria y la minería en el Valle de Sogamoso.
¿Podemos mentirle al asesino frente a la puerta? Un análisis de la filosofía kantiana sobre la mentira
Authors: González-Valderrama Leonardo
Published: December 2022

La filosofía moral kantiana ha sido criticada por su compromiso con el rigorismo moral. Esta crítica está basada en la posición kantiana respecto a la mentira; específicamente, se deriva de la afirmación de Kant de que es un deber ser veraces incluso con el asesino que llega a casa preguntando por el paradero del amigo refugiado. Este artículo tiene un carácter enteramente expositivo y tiene el objetivo de reconstruir y examinar la posición de Kant frente a la mentira para determinar si la acusación rigorista está bien fundamentada. Examino tres fuentes: Lecciones de ética (§1.1), “Sobre un supuesto derecho a mentir por filantropía” (§1.2) y Metafísica de las costumbres (§1.3). De este examen comparativo, concluyo que no existe evidencia textual que demuestre que Kant defienda categóricamente el deber de ser veraces en el caso del asesino en la puerta, de manera que la acusación de rigorismo que pesa en contra de la filosofía moral kantiana, al menos en lo que respecta a este caso en particular, no parece estar bien fundamentada.
Sinequismo y teleología evolutiva como constituyentes de la propuesta realista de Charles Sanders Peirce contra el nominalismo
Authors: González-Parra Dany Mauricio
Published: December 2022

El presente trabajo tiene el propósito de aclarar el sentido del realismo que suscribe Charles Sanders Peirce desde su pragmaticismo. Dado que este realismo tiene sus bases en los planteamientos peirceanos concernientes a la lógica de la investigación y a su propuesta metafísica, el primer objetivo es ubicarlo en el marco de la discusión alrededor de diferentes propuestas realistas epistemológicas y ontológicas. Con base en esto, en un segundo momento, se precisará la propuesta realista que se desprende de su doctrina de la continuidad o sinequismo. Finalmente, se expondrán los rasgos generales de la teleología evolutiva en la que desemboca dicha propuesta.
Discurso, política y verdad: Michel Foucault y la función del intelectual
Authors: Camelo-Perdomo Diego Fernando
Published: December 2022

El objetivo del siguiente artículo es identificar los elementos que componen la función del intelectual en Michel Foucault y explicar el modo cómo ellos actúan. La tesis que se desarrollará es que dicha función se entiende a partir de los efectos políticos producidos por discursos de verdad. Se argumentará que en ella se concatenan estos tres elementos (Discurso, política y verdad) siendo atravesados por las relaciones de poder. Finalmente, se demostrará que su campo de acción se encuentra articulado con el análisis de los discursos que funcionan políticamente conforme a unos regímenes de verdad.
Design of Multilateral Wells for the Conditions of Guajira Offshore Basin in the Colombian Caribbean Sea
Authors: Ariza-León Emiliano , Ortiz-Riaño Daniel Sebastián , Rodríguez-Turizo Geovanni , Cabrera-Tovar Jairo Humberto
Published: December 2022

This article proposes the design of a multilateral well on the Tayrona area conditions located in the Guajira Offshore basin that belongs to the Colombian Caribbean. This zone has a strategic importance for Colombia, because is where the Orca-1 well was drilled, integrating a substantial gas reservoir detection in 2014, which is a project with great development potential, that can help meet the energy needs of the country, where Ecopetrol, Petrobras, and Repsol are contributing. Reviewed to know about the technique of drilling multilateral wells, perform an analysis of the conventional and modern existing alternatives and both the environmental and operational variables influencing the drilling of this kind of offshore wells. In addition, a research study of environmental and geological conditions of the interest area, the Colombian Guajira offshore, was carried out to determine the feasibility of the application of this technology. The design of the multilateral well UIS-OFF-MO1 was proposed, with two opposite branches to increase production in the reservoir in which Orca-1 well is situated, to increase the drainage area and contact an area of the reservoir, which is separated by a normal no-flow fault.
Promentors – Promoting Mentors’ Work in Education. Analiza założeń oraz efektów projektu
Authors: Szudra-Barszcz Anna , Amilkiewicz-Marek Agnieszka
Published: December 2022

Promentors to projekt międzynarodowy. Jego uczestnicy szukają inspiracji do poprawy jakości kształcenia nauczycieli opierając się na założeniach różnych modeli mentoringu. W maju bieżącego roku polem ich poszukiwań stał się Lublin. W odpowiedzi na tę potrzebę zespół z Katolickiego Uniwersytetu Lubelskiego Jana Pawła II zorganizował czterodniowe spotkanie, podczas którego zagraniczni goście, studenci, doradcy metodyczni z Lublina, dyrektorzy różnych placówek edukacyjnych (państwowych i niepublicznych) oraz nauczyciele mieli okazję wymienić się doświadczeniami i efektami swoich działań w zakresie mentoringu.
The Effect of Traditional Home Remedies on Glycemic Control among People with Type 2 Diabetes Mellitus (T2DM)
Authors: Matpady Prabhath , Maiya G. Arun , Gaundar Niroshkanaa , Shetty Jeevan K , Bhojaraja Vijayalakshmi S , D S Anupama , Umakanth Shashikiran
Published: December 2022

Traditional home remedy consumption is a typical ancient practice in India. These traditional home remedies are found to have beneficial effects on many chronic conditions. This study was designed to explore the effect of traditional home remedies on glycemic control in people with type 2 Diabetes Mellitus (DM). In this study, 148 type-2 DM patients aged between 35 and 70 of both genders, participated. Among 148 type-2 DM patients, 102 T2DM patients use traditional home remedies along with oral anti-diabetic drugs, while the remaining 46 are non-users. The details of age, duration of type- 2 DM, glycated Hb (HbA1c) values, and use of traditional home remedies were obtained from a cross-sectional survey. The HbA1c value of 7-8% was considered an optimal target glycemic control, and ≤ 7% was considered poor control. A mean and SD were used to represent descriptive statistics. An independent sample test was used to compare the mean HBA1c between the fenugreek users and non-users by considering p<0.05 as statistically significant. The majority of type- 2 DM in our study group used Trigonella foenum-graecum (Fenugreek) (76.47%). A small proportion of our study group is using Azadirachta indica (Indian lilac or neem) (7.84%), Momordica charantia (bitter guard) (3.93%), and Aegle marmelos L. (Bengal quince or bael) (2.94%). The HbA1c levels in the majority of the traditional home remedy users were within the recommended target levels. The mean HbA1c levels of fenugreek non-users were significantly higher (p<0.001) than fenugreek users. In conclusion, our study shows that type-2 DM traditional home remedy users have better glycemic control than non-users. Home remedies are potent natural food sources that can be used with anti-diabetic drugs. However, such a use should be done with the knowledge of treating doctors, which may help to achieve better glycemic control and prevent type-2 DM-related complications.
Herbs as Antidote for Snake Bite Treatment- Traditional Practices and Its Future Prospects- A Review
Authors: David Paul Raj R. S. , Ann Mathew Alina , Jesse Joel T. , Beena Kanimozhi R. , Agnes Preethy H.
Published: December 2022

Snake bite is a life-threatening neglected tropical infection reporting high mortality across the world including India. Out of the available yearly statistics of this occupational hazard caused 4.5-5.4 million people and nearly 1,38,000 fatalities were reported globally. Several factors such as the low availability of antivenom, inadequate health centres in rural areas, poor transportation facilities affected the higher number of morbidity and mortality cases of snake bite. The prognostic and diagnostic approach towards the snake bite infection is difficult due to its complexity in venom. The conventional therapy is polyvalent antivenom derived from horses or sheep, with its limitations. The traditional physicians use plants and other herbs as its sustainable remedy for snake bite treatment. Nearly, 523 plant species from 122 families reported their neutralizing property against toxic venom. The secondary metabolites extracted from plants, are capable of reducing the toxic effects of the venom. Many research works has been reported the inhibitory potential of the plant compounds against the snake venom enzymes. Therefore, there is a necessity for increasing therapeutic studies on plant metabolites and the development of an antidote for the better treatment of snakebite. This review article discusses various herbal plant used for snake bite in India.
Some Less Known Medicinal Plants of Haryana
Authors: Kumar Chaudhary Akshay , Devashree Yumnam
Published: December 2022

Plants of medicinal importance have been the life saviours of the human race before the discovery of modern medicines. The use of plants as a source of medicine has been recorded from a 60000-year old grave. With the establishment of AYUSH, the Indian government is working to elevate herbal medicine to mainstream medicine. The Indian government is currently working hard to increase the use of plants as medicines. Plants are an easily available resource for natives and the poor for treating various diseases. Therefore, the aim of the present review is to understand the knowledge of medicinal plants as a future source of herbal drugs, to find various plants useful as medicinal plants in Haryana, and to create a catalogue of all medicinal plants present in Haryana as found by various researchers. About 700 plants were described in the Charaka Samhita and Sushruta Samhita during the 1st millennium BC. Haryana is a state in northern India, neighbouring Delhi. The study was conducted to enlist the various plants of medicinal importance in Haryana. Various studies have been conducted in Haryana to enlighten the various medicinal plants found in Haryana, but these studies only cover medicinal plants in 10 out of 22 districts of Haryana, which is less than one-fourth. There is huge potential for finding numerous local medicinal species in Haryana which may treat numerous underlying diseases. Various medicinal plants have been enlisted which are found by local communities as having immense benefits as medicines that are being used by local communities numerous times. This knowledge is found through continuous hit and trial by generations of communities and has got immense knowledge about various medicinal plants, but this knowledge is getting lost due to incomparability in cataloguing the knowledge present in these communities, such as the Sapera community.
Phytochemical Profiling of Various Extracts of Glycine max (L.) Seeds and In-silico Approach for Hepato-Protective Activity
Authors: S Vishnupriya , S Kowsalya
Published: December 2022

Cirrhosis and fibrosis are mainly characterized by the frequent and repeated inflammation of the renal cells. These renal disorders may also lead to hepatocarcinoma and even death, so we are in need of complementary and alternative medicine to treat renal diseases. The Soybean (Glycine max (L.) Merr.) seed is reported to have medicinal properties and pharmacological activities like anti-inflammatory and anti-oxidant. Here, we have evaluated various extracts (Water, Ethanol, Methanol, Hexane and Benzene) of Glycine max (L.) to predict their phytoconstituents and found that methanolic extract has more phytoconstituents. The finest chemicals in the methanolic extract, such as 3-Methoxy-hexane-1,6- diol, Choline, 9,12,15-Octadecatrien-1-ol, and tetradecane, were docked against Transforming Growth Factor-(TGF-β) a cytokine, transcription factors such as Peroxisome Proliferator-Activated Receptor (PPAR) and Pregnene X Receptor (PXR), and Nuclear Factor kappa-b (NF-KB) a protein complex. Comparatively, Choline shows higher negative binding energies against all the receptors and possesses hepato-protective activity.
Therapeutic Effect of Aloe vera on Croton Oil Induced Hemorrhoids
Authors: Suresh Swathi , Ankul Singh S. , Vellapandian Chitra
Published: December 2022

Hemorrhoids are vascular structures in the anal canal with swollen veins in the lowest part of the rectum/anus. Till date, there is no specific treatment available for different grades of hemorrhoids. However, it is evident that lesser invasive options are to have opted for at the earliest along with conservative measures such as analgesics and anti-inflammatory agents. The study evaluates the efficacy of gel obtained from Aloe barbadensis Miller in treating hemorrhoids in a croton oil-induced Wistar rat model. Animals were allocated into 5 groups. Group I and II served as the normal and negative control, Group III as standard, and Group IV and V received an oral route and a topical route respectively. Biochemical parameters such as TNF-? and IL-6 were estimated in each group after the therapy of 5 days. Quantitative estimation of edema was done by determining the Evans blue dye concentration in the plasma exudates in recto-anal tissue. The recto-anal coefficient was estimated as a direct measure of inflammation. Histopathological variations among the groups were analyzed. Statistical analysis of the data affirms the curative effect of aloe vera on Hemorrhoids. Results demonstrate that aloe gel is much more effective when compared to Pilex ointment which was used as standard (p<0.05). However, oral preparation was not found to be effective in mitigating the disease as that standard (p>0.05).
Formulation, Standardization, and Preclinical Evaluation of Polyherbal Suspension against Inflammatory Bowel Disease
Authors: Dubey Prerna , Fatma Begum Rukaiah , Chitra V. , Mrinalini R. , Gunasekaran Harini , Sumithra M.
Published: December 2022

The pharmacological healing for inflammatory bowel diseases continues to be uncertain and requires immediate therapeutic interventions. A poly-herbal formulation obtained from a traditional and authentic classic text of Ayurveda was assessed for its effect against IBD (inflammatory bowel disease) in this study. The formulated poly-herbal suspension comprises three different drugs namely, Burma dhaniya (Eryngium foetidum), Sapota (Manilkara zapota), and Curry leaves (Murraya koenigii). The formulated suspension was evaluated for certain standard parameters like organoleptic and accelerated stability studies at various temperatures. It was checked for its efficacy by oral route in acetic acid-induced colitis affected Balb/c mice. Mice were orally administered with formulated suspension (275 mg/kg, 550 mg/kg,), every 24 hours for 10 days. Histopathology, macroscopic damage score, myeloperoxidase (MPO) activity, and red blood cell parameters were evaluated after treatment. Reduction in the MPO activity, decrease in the macroscopic damage scores, and an increase in RBC cell count were seen distinctly at a high dose of 550 mg/Kg. The results obtained, established the effectiveness of the poly-herbal suspension against inflammatory bowel disease by treating the mice from acetic acid-induced colitis by reducing inflammation and oxidative damage to the colon. The maximum therapeutic effective activity was found to be 550 mg/kg for IBD mice.
Anti-BPH Activity of Polyherbal Formulation on Testosterone Induced Benign Prostatic Hyperplasia in Rats
Authors: Dalal Mittal , Soni Hardik , Patel Devanshu J. , Das Mandal Snigdha , Vashi Jainee Daxesh
Published: December 2022

Benign prostatic hyperplasia (BPH) is an enlargement of the prostate gland caused by progressive hyperplasia, or abnormal growth of cells of the glandular epithelial and stromal cells. Globally, it has been documented that more than 80% of men by the age of 80 will suffer from BPH. Most men are hesitant to undergo surgical interventions for fear of losing potency and the perception of other adverse side effects. Effectto® is a polyherbal formulation designed by Vasu Research Center to be used for the treatment of BPH. It can also be indicated that it can be used for lower urinary tract symptoms and bladder outlet obstruction. The formulation is expected to provide significant BPH relief. The present study was planned to evaluate the effect of a polyherbal formulation on testosterone- and citral-induced Prostatic Hyperplasia. The activity of the polyherbal formulation for BPH was evaluated using testosterone depot injection as the inducing agent in a testosterone-induced model and citral-induced model for the atypical type of BPH in rats. Also, the acute toxicity study was done using OECD 423 guidelines to check the toxicity of the test compound. Data are expressed as mean ± SD and statistical significance was evaluated using one way ANOVA followed by Tukey’s multiple comparison tests. The polyherbal formulation was found to be safe at oral doses of 2000 mg/kg. Effectto® significantly decreased the weight of the prostate in the testosterone model as well as the citral model in rats. The effect on biochemical markers like serum PSA and TNF-α was also seen in both the cases. In particular serum PSA, the decrease was majorly significant in both the models when XIII compared. The formulation was able to reverse the effect of inducing agents on the prostate’s size.
1970-2000 Yılları Arası Türkiye’de Radikal İslamî Hareketler
Authors: BALCI Ali Osman
Published: December 2022

Radikal İslâmî söylemin temelleri İslam’ın ilk dönemlerinde ortaya çıkan farklı anlayışlara kadar götürülebilmektedir. Türkiye’de Cumhuriyet’in ilanından itibaren toplumsal değişimin sağlanması için uygulanan baskıcı politikalar ve dışarıdan taşınan bazı dinî anlayışlar, radikal hareketlerin oluşum sürecini hızlandırmıştır. Sadece fikrî anlamda değil fiili anlamda da mücadele içerisine giren ve devlet rejimine karşı olmak konusunda birleşen bu gruplar özellikle 1970’li yıllardan itibaren ortaya çıkmaya başlamışlardır. Toplumsal kargaşanın hakim olduğu bu dönemlerde, kurtuluşun ancak İslamî kurallara dönülerek sağlanacağını savunan bu hareketler, izlenecek metodoloji noktasında birbirlerinden ayrılmaktadırlar. Bu çalışmada, Türkiye’de 1970-2000 yılları arasında etkili olan ve halen etkileri devam eden, radikal olarak değerlendirilebilecek hareketlerden öne çıkanlar, tarafsızlık ilkesi içerisinde ortaya konulmaya çalışılmıştır.
SPHERICALLY SYMMETRIC SYSTEM OF GRAVITATIONAL AND ELECTROMAGNETIC FIELDS AND THE STRUCTURE OF ITS CONFIGURATION SPACE
Authors: Gladush V.D.
Published: December 2022

Geometrodynamics of charged black holes (BH) described by the system of Maxwell Einstein equations is considered. We start from a spherically symmetric metric, a reduced action, and a Lagrangian written in characteristic variables. The configuration space (CS) metric, Hamiltonian, momentum and electromagnetic constraints are constructed. The system has conservation laws of charge q and mass m. The action functional is transformed into a Jacobi-type functional in CS with a metric conformal to the CS metric. A transformation of field variables is introduced which brings the CS metric to the "Lorentzian"form. The resulting CS metric is the metric of a flat nonholonomic section of a 4-dimensional space. In the new variables, the squared momenta of the system has the Lorentz form. On this basis, quantization is considered. Thanks to the structure of the CS, the momentum operators, the DeWitt equations, and the mass and charge operators are constructed. The equations system of CBH quantum states with certain q and m is constructed. For comparison, we consider the CBH reduced model limited in the T-region. In such the simplified formulation, the T-model equations are integrated and lead to the CBH with continuous spectrum of m and q.
ANGULAR STRUCTURE OF THE RADIO GALAXY 3C239 IN THE DECAMETER RANGE
Authors: Vashchishyn R.V. , Shepelev V.A. , Litvinenko O.A. , Podgorny G.S. Podgorny , Derevyagin V.G. , Lozonsky A.V.
Published: December 2022

We present the results of the observation of the radio galaxy 3C239 with the URAN interferometers at the decameter wavelengths. According to our study, the source in this range consists of two components that coincide in position and size with the lobes of the radio galaxy observed at the decimeter wavelengths, and a compact component corresponding to one of its hot spots. Another hot spot is not detected due to its low flux density at decameter wavelengths. In addition, an extended region of radiation with low surface brightness was detected, which surrounds the source lobes. The size of this halo is 28 arcsec, and its emission at the frequency of 25 MHz is about 20% of the total flux of the radio galaxy. A possible view of spectra of the radio source components and their variation in the range from decameter to decimeter wavelengths are determined. It is noted that in contrast to the high-frequency structure of 3C239, where radiation of the compact hot spots dominates, at decameter wavelengths about 90% of the radio galaxy flux is provided by more extended components — the source lobes and the halo.
DETERMINATION DEGRADATION OF SATELLITE SURFACE OPTICAL FEATURES BY PHOTOMETRIC METHOD
Authors: Sukhov Peter. P. , Yepishev Vitaly P. , Sukhov Konstantin P. , Pavlovskyi Alexei L. , Mamrai Sergei A.
Published: December 2022

A method is described for using photometric data to estimate the reflective properties of a satellite's surface material under conditions of its long stay in space. The technique of multicolour photometric B,V,R observations of several geostationary satellites built on different types of tires is shown, and the results obtained over a period of 3 to 9 years. These are geostationary satellites Astra 2E (on the Eurostar E3000 bus), Azerspace 2/Intelsat 38 (on the SSL-1300 bus), Sicral 2 (on the Spacebus-4000B2 platform) and Blagovest 11L (the Ekspress-2000 bus). It has been revealed that a pattern of change in the reflectivity of different geostationary satellites is dissimilar. Spacecraft materials used for the surfaces of geostationary satellites manufactured in the second decade of the 21 st century are more resistant to the harsh space environment than those used for the satellites built in the late 20 th century. We have proposed several ways of improving the method for identifying the spacecraft material type based on multicolour photometric observations. The presented results show that the proposed photometric method works and can be used for detecting spacecraft surface degradation.
PHYSICAL PROPERTIES OF “HOT POPULATION” OBJECTS IN THE KUIPER BELT
Authors: Okhotko N. , Troianskyi V. , Bazyey O.
Published: December 2022

Most planetesimals formed at distances of 15 - 30 a.u. were gravitationally ejected from the Solar system as a result of the migration of the giant planets, but a small part remained, captured by Jupiter and the Kuiper belt. As a result, we can now observe such a variety, in terms of physical and dynamic characteristics, in the Trojan asteroids of Jupiter and in the Kuiper belt. Planetesimals captured by the Kuiper Belt are a "hot population" now. The term "hot" does not refer to the temperature of bodies, but characterizes the orbit of objects. ~120,000 objects larger than 100 km. in diameter are known in the "hot population". This population is characterized by an orbital inclina- tion greater than 5 degrees and a large eccentricity. The main task of the work, based on physical and dynamic characteristics, is to search for the same properties Trojan asteroids of Jupiter and objects from the "hot population" of the Kuiper belt, which supposedly migrated earlier from the region of the original orbit of Neptune. The data from ground-based observations and space missions is used in the work.