bluuebunny/crossref_metadata_2025 huggingface dataset:
Peran Penggunaan Teknologi Digital Terhadap Kesuksesan dan Kegagalan E-bisnis di Era Digital
Authors: Muhammad Deary  , Gilang Dwi Prasetyo  , Rohid Akbar  , M Yuda Al- Faruq  , Nurbaiti Nurbaiti
Published: January 2025

In current technological advances, digital technology has developed rapidly in assisting human activities, for example in the business sector. In today's digital era, technology plays an important role in the changes that occur in business activities, which previously could only be done face to face between the seller and the buyer, now with only e-commerce technology, buyers do not have to meet the seller to buy the product or service they need. . However, when using e-commerce technology, you must pay attention to what is needed between buyers who want to look for the goods or services they need and sellers who sell their goods or services so that when the business process occurs there will be no failure later.
STRATEGI EFEKTIF DALAM MENINGKATKAN PENJUALAN MELALUI SOSIAL MEDIA DI ERA DIGITAL
Authors: Afriani Afriani  , Yuni Fatma Sari  , Siti Hansyah Dewi Zai  , Fanny Himla Rizqya Pasaribu  , Nurbaiti Nurbaiti
Published: January 2025

This study examines effective strategies in increasing sales through social media in the digital era. With the increasing use of social media platforms, businesses need to adopt innovative approaches to reach a wider audience. This study uses qualitative methods to explore various social marketing techniques that can increase sales engagement and conversion. The results show that building credibility, quality content, active interaction, and collaboration with influencers are key factors in achieving sales goals. The development of digital technology has changed the way companies market their products and services. Social media has become an important platform in reaching consumers more closely, and has the potential to increase sales significantly. This article discusses effective social media marketing strategies in increasing sales such as developing interesting content, utilizing influencers, using paid advertising and fast customer interaction and service that are often encountered in social media marketing strategies and how to utilize data analytics to support marketing decisions.
Pengendalian Kualitas Produk Menggunakan Metode Six Sigma pada UD. Telur Murah
Authors: Siti Yulia Salsa Fahrani  , Wiji S  , Marcellawati
Published: January 2025

UD Telur Murah is a business engaged in selling domestic chicken eggs. The problem that occurs is the high number of egg defects. This study aims to determine the causative factors of defects and proposed product quality control using the six sigma method. Egg defect data uses historical data, namely the defect period from September 2022 to August 2023. This research uses SIPOC Diagram, Pareto Diagram, Fishbone Diagram. After identifying the cause of the defect from material factors, namely the level of sress and age in chickens. Method factors are the production process, storage of eggs in crates, and egg packaging. The labor factor is fatigue. Mother nature factors caused by hot air temperatures. Environmental factors are an increase in Ph. Based on the 5W + 1H analysis, the proposal to improve material factors is the provision of vitamins and cage cleanliness that must be maintained, method factors, enforcing SOP, man factors, short rest systems for 10 minutes, air conditioning and adequate ventilation, mother nature factors, periodic checking of room temperature.
Research Progress of Alzheimer’s Disease Monoclonal Antibodiesand Their Safety Assessments
Authors: Pan Yangxi
Published: January 2025

This article focused on discussing two monoclonal antibodies (mAbs), lecanemab and aducanumab, which target at amyloid-beta protofibrils and fibrils as amyloid-beta plaques are considered as the key pathogenesis of Alzheimer’s disease (AD). Detailed mechanism of AD including the formation of amyloid-beta plaques and tau protein was explained, as well as the efficacy, benefits and limitations of these two mAbs are discussed. Current studies shown that lecanemab and aducanumab have efficacy on reducing amyloid-beta plaques in AD patients. There are limitations to the usage of both lecanemab and aducanumab, such as the appearance of amyloid-relating imaging abnormalities (ARIA). However, findings suggested that less ARIA occurred in the administration of lecanemab, and to the most harmful kind of amyloid protein, lecanemab binds more tightly compared to aducanumab. Therefore, safety assessment of these two mAbs should also be considered. This article only focused on lecanemab and aducanumab, donanemab which was approved recently is not mentioned. It is worth pointing out that the appearance of lecanemab and aducanumab had revolutionized the treatment for AD, as this improve the life quality of AD patients. More effective mAbs and other treatments are still under investigations in order to lower the incidence, and provide more hope for curing AD.
Emerging Role of Vaccines in Glioblastoma Treatment
Authors: Guo Ruidong
Published: January 2025

Glioblastoma is the most common primary intracranial malignant tumor, classified by the World Health Organization as a grade IV glioma of the central nervous system due to its high mortality, recurrence rate, and morbidity. This disease has difficulty to treat. Currently commonly used therapies, such as surgery, chemotherapy and radiotherapy, have poor prognosis. Therefore, new treatments are needed to control tumor progression and improve patient outcomes. After years of development, cancer vaccines have gradually become an important part of tumor immunotherapy, and they have shown a more rapid development trend in the current era. Cancer vaccines introduce tumor antigens, genes encoding tumor antigens, immune cells, and molecules into the body. Cancer vaccines activate specific immune responses that control tumor growth and ultimately clean it. In recent years, a number of research groups at home and abroad have explored the safety and feasibility of different types of therapeutic vaccines for the treatment of GBM according to the characteristics of GBM. This review introduces results, mechanism, safety and efficacy of virus-like particles (VLPs) vaccine, mRNA vaccine and dendritic cells (DC) vaccine. The feasibility of using these vaccines to treat GBM was discussed to provide reference for further research.
Comparative Analysis of ICIs, CAR-T Therapy, and Cancer Vaccines in Immunotherapy
Authors: Chen Junyi , Liu Ansong , Yao Yao
Published: January 2025

Immunotherapy is a popular cancer treatment, which mainly focuses on regulating the body's own immune response to achieve the goal of treatment. There are many different treatments available in this field, each with its own advantages and disadvantages. But there are still problems that have not yet been resolved. This article analyzes the research of ICIs, CAR-T cell therapy, and tumor vaccines, summarizes their characteristics and compares them. This study provides a horizontal comparison of ICIs, CAR-T therapies, and cancer vaccines in terms of efficacy, safety, and adaptability in cancer treatment. ICIs demonstrate broad applicability and validated efficacy but are not universally effective. CAR-T therapies show significant efficacy in hematological malignancies but face challenges in solid tumors. Cancer vaccines offer potential but are less universally effective. Safety profiles vary, with ICIs manageable through pharmacological interventions, CAR-T therapies requiring careful management due to serious side effects, and cancer vaccines showing generally mild adverse events. However, there are still substantive problems that have not been solved, and future research can focus on clinical research directions.
The Specific Mechanism of Th1Th2 Balance in Tumor Immunity
Authors: Li Zaixi
Published: January 2025

With the development of modern science, tumor immune microenvironment (TME) has become the mainstream of research. There are many related studies on Th1/Th2, so it is important to bring together such studies. At present, the research on Th1/Th2 mainly focuses on the following aspects: the mechanism of Th1/Th2 cells in TME, the inhibitory effect of Th1 cells in tumor tissues, and the related therapies for Th1/Th2 cell balance. However, there are few studies that summarize the above research directions. In this paper, the interaction between Th1 and Th2 was elaborated and found that Th2 interfered with the normal anti-tumor function of Th1 inhibition in TME, and MDSC was produced and accumulated in tumor tissues, resulting in the increase of MDSC. MDSCs can show effective immunosuppressive and tumor-promoting functions in TME through a variety of mechanisms, and together with M2 macrophages, they can assist Th2 to exert inhibitory effects on Th1 and CD8+ T cells. Saikosaponin A and xanthohumol can effectively balance Th1/Th2 to achieve the effect of treating tumors. This study reveals the specific interaction mechanism of Th2 and Th1 in TME, elucidates the inhibitory role of Th1 cells in tumor tissues, and summarizes the research results in related fields in recent years, as well as the current research progress in related fields.
Progress in The Application of CRISPR-Cas9 Combined With Microbial Engineering
Authors: Xing Xindan
Published: January 2025

CRISPR - Cas9 as the third generation of gene editing techniques, widely exists in prokaryotes, and has been widely applied to clinical and pharmaceutical fields. This article reviews the discovery, immune defense process and mechanism of CRISPR-Cas9 and summarizes its application in microbial cells. Advances include achieving gene editing in E. coli, improving defense against phages, and stabilizing chemical production; It is used to modify the characteristics of lactic acid bacteria and precise genome editing in algae; In terms of viruses, it can be used to treat HIV-1 infection, hemoglobinopathy, etc. Research gaps include less research on the effect of optimal length and selective markers of donor DNA homologous arms on efficiency in bacterial gene editing and insufficient evaluation of potential off-target effects and long-term effects of CRISPR/Cas9 systems in algae. This paper mainly analyzed the application of CRISPR-Cas9 in bacteria, lactic acid bacteria, algae, and viruses, and obtained corresponding research results. It provides a theoretical basis and a new idea for the research in the field of microbiology, but there are still some problems to be solved, and future research can focus on optimizing the system, reducing the off-target rate, and improving the editing efficiency.
The Preparation of Molecularly Imprinted Polymers and the Application in Pharmaceutical Analysis
Authors: Lan Ziyi
Published: January 2025

Molecular imprinting technology (MIT) is an artificial method for preparing polymers with specific recognition of target molecules. Molecularly imprinted polymers (MIPs) have been widely used in electrochemical sensors due to their simple preparation, good stability, and molecular recognition function. Especially in drug analysis, MIPs-based electrochemical sensors have become a research hotspot. Therefore, this work focuses on MIPs-based electrochemical sensors. The performance of MIPs is closely related to their preparation methods. In this work, the preparation methods of MIPs are discussed in detail. This work also discussed MIP-based electrochemical sensors. MIP-based electrochemical sensors have achieved accurate detection in flavonoid and antibiotic drugs. Meanwhile, as a polymer, MIPs can also have an impact on the conductivity of working electrode. Therefore, it is necessary to choose some nanomaterials with excellent conductivity for its modification. In the future, molecular imprinting technology will have more applications in electrochemical sensors. In drug analysis, more imprinting targets should be explored for detection by using this technology.
The role of aspirin in cancer treatment
Authors: Gao Ya
Published: January 2025

Aspirin has attracted attention for its potential to prevent cancer, especially for the treatment of colorectal cancer. Historically, aspirin can be used for the prevention of cardiovascular disease because of its ability to irreversibly convert acetylcyclooxygenase (COX)-1, which inhibits platelet aggregation. In addition, aspirin can be also used to reduce cancer incidence and mortality, showing a good application for cancer treatment. The evolution of the role of aspirin is explored here, with a focus on the epidemiological and clinical evidence supporting its anticancer effects, where low-dose aspirin can reduce overall cancer incidence and mortality by 20-30%. Potential mechanisms of aspirin, including inhibition of platelet activation and inhibition of tumor-promoting pathways, are also discussed. Despite these findings, the use of aspirin must balance benefits with bleeding risk, especially in average-risk populations. Future studies should focus on determining the optimal dosing regimen and identifying the population that would benefit most from the cancer-preventive effects of aspirin.
The Role of PD-1/PD-L1 Inhibitors in the Treatment of Nasopharyngeal Carcinoma in the Epstein-barr Virus Microenvironment
Authors: Luo Xuanyue
Published: January 2025

This article offers an extensive examination of nasopharyngeal carcinoma (NPC), with a particular emphasis on its epidemiological features, relationship with Epstein-Barr virus (EBV) infection, classification system, and current immunotherapy approaches. NPC is notably prevalent in East and Southeast Asia, displaying a robust association with EBV infection, particularly in the non-keratinized subtype. Considering the successful implementation of PD-1/PD-L1 immune checkpoint substance across various cancer, their potential therapeutic benefits in NPC have attracted considerable attention. Although PD-1/PD-L1 inhibitors have exhibited effectualness in NPC patients, the response rate remains inconsistent, suggesting a requirement for deeper investigation into the regulatory mechanisms that govern PD-L1 expression. Furthermore, the approach of combined interferon therapy, designed to augment anti-tumor immunity, has demonstrated potential in enhancing therapeutic outcomes and extending patient survival when administered concomitantly with PD-1/PD-L1 inhibitors. However, several obstacles remain, including drug resistance and the substantial heterogeneity observed in NPC tumors. Tumors from different patients display variations in gene expression patterns, immune microenvironment composition, and other factors, which may lead to divergent patient responses to the combined treatment regimen of PD-1/PD-L1 inhibitors and interferon. This article highlights the research significance of PD-1/PD-L1 combined with interferon in NPC treatment and anticipates its extensive clinical application in the future. Nonetheless, to achieve this goal, several challenges must be tackled through persistent and rigorous research and exploration.
Recent Progress of Irreversible BTK Inhibitors
Authors: Zhao Wenxi
Published: January 2025

In recent years, Bruton tyrosine kinase (BTK) inhibitors that selectively inhibit B cell receptor (BCR) signaling have become a popular and effective treatment for lymphomas in the public. As the pivotal tyrosine kinase BTK regulates the BCR pathway, BTK inhibitors were developed to block the pathway by binding with BTK thereby relieving the B-cell lymphoma progression. Ibrutinib, the first-generation BTK inhibitor, can effectively inhibit BTK and alleviate various cancer diseases. However, ibrutinib's lack of selectivity has led to a series of side effects, having adverse effects on survival rates and tolerability. By altering the molecular structure, researchers have developed the next-generation irreversible BTK inhibitors aiming at increasing target specificity and decreasing off-target impacts, such as acalabrutinib, tirabrutinib, spebrutinib, branebrutinib, and zanubrutinib, who recently received approval by FDA. This article compares and analyzes the advantages and disadvantages of these irreversible BTK inhibitors, especially zanubrutinib, with ibrutinib and finally draws a conclusion.
mRNA Vaccines in Glioma: Antigen Selection, Immune Profiling, Comprehensive Strategies and Challenges
Authors: Yang Fan
Published: January 2025

Glioma is one of the most invasive primary brain tumors, and the exploration of its treatment strategies has always been a focus in the field of neurooncology. In recent years, mRNA vaccine technology has shown great potential in the COVID-19 epidemic, and its application in the treatment of glioma has also attracted increasing attention. This article reviews the research progress of mRNA vaccines in the treatment of glioma, including the advantages and challenges of mRNA vaccines, the comparison of different RNA therapy methods, as well as the screening of tumor specific antigens, differentiation of immune subtypes, and development of comprehensive treatment strategies. Although mRNA vaccines have shown promising prospects in the treatment of gliomas, their clinical translation still faces challenges such as safety, production scale, and cost-effectiveness. The author believes that a deep understanding of the molecular mechanisms of glioma and the heterogeneity of the immune microenvironment is crucial for developing effective mRNA vaccines. Future research needs to make breakthroughs in improving the stability of mRNA vaccines, optimizing immunogenicity, developing personalized vaccines, and comprehensive treatment strategies.
Nonsurgical Treatment and Prevention of Osgood Schlatter Disease
Authors: Xu Haoqian
Published: January 2025

Teenagers are starting to participate in sports in greater numbers due to the recent expansion in the sports business and the spectacular holding of the Olympics in Paris. However, sports injuries during the sports process are also an unavoidable problem, such as tibial tuberosity osteochondritis (OSD), which is a high-incidence disease among adolescent athletes and is troubling many teenagers. The youth population represents the future of a country. Therefore, it is crucial to help them avoid OSD as much as possible and recover from it as soon as possible. This article briefly describes the diagnostic methods and risk factors of OSD, including clinical manifestations and analysis of the advantages and disadvantages of different diagnostic methods such as X-ray, ultrasound, and MRI. The focus is on non-surgical treatment and prevention of OSD, with a particular emphasis on physical therapy (including strength training (core stability training, and lower limb strength training), activity adjustment, stretching, and rehabilitation massage, as well as wearing orthopedic devices) and medication therapy.
Impact of the Pentavalent Meningococcal Conjugate Vaccine(NmCV-5) Targeting Serogroups A,C,Y,W, and X on the Sub-Saharan Africa Region
Authors: Zhang Yuxiang
Published: January 2025

Meningococcal disease poses a considerable public health burden in sub-Saharan Africa (SSA), particularly in the "meningitis belt". Although the rollout of the serogroup A meningococcal vaccine (MenAfriVac) has effectively contributed to a significant reduction in the incidence of group A meningitis, serogroups C, W, Y, and X are experiencing rising infection rates, highlighting the urgent need for new vaccines to address the threat posed by non-serogroup A Neisseria meningitidis. Considering this, Serum Institute of India Pvt Ltd., in partnership with PATH, developed a pentavalent conjugate vaccine (NmCV-5) containing capsular polysaccharides of meningococcal serogroups: A, C, W, X and Y, conjugated to a protein carrier, tetanus toxoid. In this paper, the epidemic trend of meningococcal and the development of NmCV-5 vaccine in SSA were analyzed by literature review. It has been shown that the NmCV-5 vaccine demonstrated good safety and immunogenicity against all serogars in clinical trials, especially significant protection against Neisseria meningitidis serogroup X. The single-dose schedule of the vaccine also improves roll-out feasibility in resource-limited Settings. However, the rollout of the vaccine still faces challenges such as poor infrastructure and insufficient public awareness.
The Impact of Re-Infection With COVID-19 on Human Immunity and Coping Strategies in The Post-Pandemic Era
Authors: Zhang Xinyuan
Published: January 2025

The COVID-19 pandemic, caused by SARS-CoV-2, has led to over 6.9 million deaths as of August 2024 as a significant global health threat. While advancement of vaccines and drugs targeting SARS-CoV-2 virus has reduced severe illness, reinfection remains a significant concern. This paper explores the impact of COVID-19 reinfection on human immunity and examines possible coping strategies, particularly the advancements in plant-derived adjuvants to enhance vaccine efficacy. The virus's ability to mutate, evade immune responses, and affect immune memory highlights the importance and potential effectiveness of treatments that prolong immunity response. Plant-derived adjuvants Advax and Matrix-M have been shown to improve long term immune responses by stimulating long-lasting antibodies and cytotoxic T-cell activation. Clinical trials have demonstrated efficacy and safety in preventing symptomatic and severe COVID-19, along plant-based adjuvants reducing reinfection risks. Future research could further focus on develop precising adjuvants’ formulations, exploring more plant-based compounds that could be apply in vaccine development, and conducting long-term studies to evaluate long-term immune durability and safety of the vaccines.
Progress in Structural Modification and Anti-Tumor Activity of Plant Polysaccharides: Enhancing Efficacy and Bioavailability
Authors: Yu Zeyue , Hu Yi
Published: January 2025

Plant polysaccharides are a class of widely distributed biomolecules with significant and diverse bioactivities, such as anti-tumor, anti-inflammatory, antioxidant, antimicrobial and immunoregulation, making them promising candidates for anti-tumor biopharmaceuticals. In this review, recent advancements in the anti-tumor research of plant polysaccharides are summarized from three perspectives: the inherent anti-tumor activity of plant polysaccharides, the enhancement of this activity through chemical modifications, and the development of polysaccharide-based drug delivery systems. Chemical modifications, especially sulfation, phosphorylation, acetylation, and carboxymethylation, have been shown to significantly enhance the antitumor efficacy of plant polysaccharides by promoting apoptosis and modulating immune responses. Furthermore, polysaccharide-based drug delivery systems have been proven effective in reducing tumor drug resistance and improving bioavailability. Based on these findings, we propose two key directions for future research: first, translating these advancements into clinical applications to benefit patients, and second, deepening interdisciplinary research to further enhance our understanding and application of plant polysaccharides in cancer therapy.
Differential Effects of Bullying and Cyberbullying in Adolescent PTSD
Authors: Chen Jiaqi
Published: January 2025

School bullying and cyberbullying are common problems among adolescents, and studies show that both types of bullying are positively associated with symptoms of posttraumatic stress disorder (PTSD). The focus of this review is to compare the differences in the impact on PTSD symptoms between school bullying and cyberbullying among adolescents. This paper shows the distribution and severity of PTSD among the young participants. Participants in bullying have different roles, such as only victims, only perpetrators or witnesses. Poly-role participants are also found by other researchers. There is overlap in roles, so this study also includes this overlap, and the comparison of PTSD symptoms is mainly from the perspective of only victims and only perpetrators. Some factors for the high rates of PTSD and bullying are also mentioned in this review. For example, agreement with the aggressors and other traumas that have not been experienced. Given the significant symptoms of PTSD among adolescent participants and the negative impact of PTSD and bullying, it is important to implement practical ways to prevent bullying. In order to improve the juvenile protection, it is also necessary to identify the population most affected by bullying and the group of adolescents most likely to be targets of bullying from the overlaps.
Immune Checkpoint Inhibitors in Breast Cancer
Authors: Haruto Yuminaga
Published: January 2025

The incidence of breast cancer has risen dramatically over the past few decades and has become the most common malignancy in women. By 2040, it is expected that there will be more than 3 million new cases of breast cancer and more than 1 million deaths per year. The incidence of breast cancer has risen dramatically over the past few decades and has become the most common malignancy in women. By 2040, it is expected that there will be more than 3 million new cases of breast cancer and more than 1 million deaths per year. Immune checkpoint therapeutics was significant technological breakthrough on cancer treatment programs. It uses the body’s immune system targets and eliminates cancer cells. This therapy maintains self-tolerance and modulates the immune response to minimize tissue damage during infection. This therapy inhibits immune checkpoints such as PD-1, PD-L1, and CTLA-4, which tumors exploit to evade immune detection. By blocking these pathways, immune checkpoint inhibitors can reactivate T cells, enabling them to recognize and attack breast cancer cells. This essay will explain how does checking for inhibitors help T cells recognize the breast tumor cells, and some drugs specialize in PD-1 and CTLA-4.
Analysis of the sources, toxicity, and control methods of polybrominated diphenyl ethers
Authors: Ying Xinhang
Published: January 2025

As fire safety standards continue to rise in all sectors of society, flame retardants are increasingly being used as a key material, such as polybrominated diphenyl ethers (PBDEs). PBDEs have become a focus of public and environmental protection attention due to their difficult degradation, easy accumulation in the environment, and transfer through the food chain. This research will investigate the main sources of PBDEs and analyze in detail the migration, transformation and distribution patterns in water, atmosphere, soil and biosphere, with a view to providing a scientific basis for the subsequent environmental monitoring and management. In addition, the physicochemical properties of PBDEs which are directly related to their persistence and potential for bioaccumulation in the environment, will be systematically described. This research will delve into the specific human health hazards of PBDEs Given the hazardous nature of PBDEs, this research will propose a series of targeted strategies and measures aimed at mitigating or preventing their toxic effects.
The Early Intervention and Management of Complications After ACL Reconstruction Surgery
Authors: Xu Junqi
Published: January 2025

The anterior cruciate ligament (ACL) plays a very important role in maintaining the stability of the knee joint, which is easy to cause instability of the knee joint and seriously affect the motor function of patients. ACL reconstruction is a widely performed surgical procedure aimed at restoring knee stability and function following ACL injury. Despite its success, postoperative complications such as graft failure, arthrofibrosis, and post-traumatic osteoarthritis can significantly impact patient outcomes. Correct understanding of the complications of anterior cruciate ligament reconstruction, early detection and timely treatment are the key to obtain good surgical results. This paper provides a comprehensive review of early intervention and management strategies for these complications. It explores the underlying causes, clinical symptoms, and effective management approaches, emphasizing the importance of early detection and treatment to optimize recovery. The study contributes to the field of sports medicine by offering evidence-based guidelines to improve postoperative care and patient outcomes, thus enhancing the long-term success of ACL reconstruction surgeries.
Tumor Microenvironment Can Promote Cancer Cell Invasion and Foster Immune Suppression
Authors: Gao Rui
Published: January 2025

Immunotherapy against tumors is an emerging field and it is gaining more attention. However, the efficiency of immunotherapy can be hindered by the complexity of the tumor microenvironment. In this paper, the mechanisms by which tumor microenvironment affects immune cells cytotoxicity and how it might suggest new treatment regimes were discussed. In addition, several new in vitro experiments were listed that point to new directions of supplementary treatments to enhance immunotherapy.
Beta-Amyloid Monoclonal Antibodies for Alzheimer's Disease: Development and Challenges
Authors: Li Yiyang
Published: January 2025

As one of the most common diseases of the elderly, the detection and diagnosis of Alzheimer's disease (AD) remain a challenge at the early stage. As the disease progresses, patients will suffer from memory and cognitive loss, which will impair their ability to live independently. The care required for these patients will be costly and time-consuming, placing a significant burden on both the family and society. At the same time, Alzheimer's disease has a complex pathogenesis and there is still and there is an unmet need for drugs that can reverse the disease. The beta-amyloid (Aβ) proteins produced by improper cleavage of amyloid precursor proteins tend to aggregate into insoluble plaques in the brain. This study reviews the latest progress in the treatment of AD with Aβ monoclonal antibodies (mAbs). In recent years, aducanumab, lecanemab, donenamab have been successively approved. Besides, small molecule drugs also play an important role in AD treatment. Despite the inability to impede the progression of the disease, they are still irreplaceable and effective in relieving symptoms at this stage. In addition, as Aβ deposition begins decades before clinical symptoms appear, advances in diagnostic technology are essential for early intervention. Future research needs to pay more attention to the side effects of this therapy and their solutions.
Recent Progress in Treatment of Pulmonary Fibrosis
Authors: Wu Jieyi
Published: January 2025

Idiopathic pulmonary fibrosis (IPF) is the most common fatal interstitial lung disease.There is no known cause. Its pathogenesis is still unclear, which increases the difficulty of anti-fibrosis drug development. Only two drugs, pirfenidone and Nidanib, are approved for the treatment of IPF, and pharmacological treatments for IPF remain urgently needed.At present, researchers are still working on new drugs to treat idiopathic pulmonary fibrosis.There is an urgent need for drugs to combat pulmonary fibrosis, so researchers are constantly working on new drugs to combat it. This review describes current potential drugs for the treatment of pulmonary fibrosis. The researchers conducted clinical trials to determine the safety and effectiveness of these drugs in patients with pulmonary fibrosis. However, before the trial of some marketed drugs for new indications, the data on adverse reactions, tolerability, physical and chemical parameters, pharmacokinetics and safety have been relatively complete, and researchers have studied the mechanism of action of old drugs, so as to use them for other diseases, the strategy is a useful complement to traditional drug development efforts, offering hope to old, dormant drugs and those on the verge of failure.
Evidence-Based Recommendations on Pharmacologic Treatment for Migraine Prevention: A Clinical Practice Guideline from the Korean Headache Society
Authors: Kim Byung-Su , Chung Pil-Wook , Chung Jae Myun , Park Kwang-Yeol , Moon Heui-Soo , Park Hong-Kyun , Bae Dae-Woong , Seo Jong-Geun , Sohn Jong-Hee , Song Tae-Jin , Lee Seung-Han , Oh Kyungmi , Lee Mi Ji , Cha Myoung-Jin , Choi Yun-Ju , Choi Miyoung ,   The Clinical Practice Guideline Committee of the Korean Headache Society
Published: January 2025

Purpose: The aim of this clinical practice guideline (CPG) from the Korean Headache Society is to provide evidence-based recommendations on the pharmacologic treatment for migraine prevention in adult migraine patients.Methods: The present CPG was developed based on the guideline adaptation methodology through a comprehensive systematic search for literature published between January 2012 and July 2020. The overall quality of the CPGs was assessed using the Korean version of the Appraisal of Guidelines for Research and Evaluation II tool. High-quality CPGs were adapted to make key recommendations in terms of strength (strong or weak) and direction (for or against).Results: The authors selected nine available high-quality guidelines throughout the process of assessment of quality. Regarding oral migraine preventive medications, propranolol, metoprolol, flunarizine, sodium divalproex, and valproic acid are recommended to adult patients with episodic migraines based on high-quality evidence (“strong for”). Topiramate can be recommended for either episodic or chronic migraine (“strong for”). For migraine prevention using calcitonin gene-related peptide monoclonal antibodies, galcanezumab, fremanezumab, erenumab, and eptinezumab are recommended for adult patients with either episodic or chronic migraine on the basis of high-quality evidence (“strong for”). OnabotulinumtoxinA is recommended for adult patients with chronic migraine based on high-quality evidence (“strong for”). Last, frovatriptan, naratriptan, and zolmitriptan are recommended for short-term prevention in women with menstrual migraine (“strong for”).Conclusion: In the present CPG, the authors provide specific, straightforward, and easy-to-implement evidence-based recommendations for pharmacologic migraine prevention. Nevertheless, these recommendations should be applied in real-world clinical practice based on optimal individualization.
Pemberdayaan Komunitas Anak Jalanan Terminal Tawang Alun Berbasis Kewirausahaan dan Media Sosial (Entrepreneurship) di Kabupaten Jember
Authors: Fadlillah Fadlillah , Asnawan Asnawan , Ratnasari Khurin'In
Published: January 2025

This study wants to describe the existence of street children, street children are a group of children who spend their childhood and adolescence selling newspapers, busking, or just asking for mercy from the people they meet to meet their daily needs. Economic difficulties make them not have time to get an education like children in general. Through the empowerment program, street children are given the knowledge to be able to see various business opportunities around them, as well as be creative in utilizing everything around them. The results of this activity include: identifying the target group, exploring the problems of the target group, coordinating the theme of community service activities, preparing for the implementation of activities, implementing activities, and evaluating the activities carried out. Therefore, community service activities for street children through entrepreneurship-based training and social media are very important so that they can develop their potential in being competent and taking advantage of everything around them without having to spend a lot of money. It is hoped that with this training service, the university and the Street Child Development Institute will always provide assistance to street children in providing life skills in developing entrepreneurial potential and expanding product marketing networks through social media.
Tinjauan Hukum Terhadap Jaminan Harta Pihak Ketiga dalam Kepailitan yang Dijadikan Harta Pailit Oleh Kurator
Authors: Safirah Maharani Putri  , Muhammad Rizal Rustam
Published: January 2025

In bankruptcy proceedings, the presence of third parties whose assets are made part of the bankruptcy estate often leads to legal conflicts. The bankruptcy estate is a collection of assets managed by the curator to pay off the debtor's obligations to creditors. Problems arise when third-party assets, which should not be included in the bankruptcy estate, are included without a clear legal basis. This research aims to analyze the legal remedies that can be taken by third parties to protect their rights and interests. By reviewing the provisions in the Bankruptcy Law, as well as the prevailing practice, this study demonstrates the importance of verification of assets by the curator prior to inclusion in the bankruptcy estate. Legal procedures such as opposition (verzet) can be taken by third parties to challenge the curator's decision in the commercial court. The findings of this study highlight the need for a better understanding of third party rights and the legal mechanisms in place to prevent abuse of curator authority. It is hoped that this study will provide guidance to third parties in taking appropriate legal steps and strengthening legal protection in the bankruptcy process.
Multiple Burden Perempuan dalam Perspektif Tafsir al-Qurthubi dan al-Maraghi: Studi Komparatif
Authors: Ma'rifah Imroatul , Nasrulloh Nasrulloh
Published: January 2025

Tafsir al-Qurthubi dan al-Maraghi tentang "Multiple Burden Women" adalah topik yang menarik untuk melihat bagaimana dua ulama besar ini memaknai dan menafsirkan peran dan tanggung jawab perempuan dalam konteks sosial dan religius. Tafsir al-Qurthubi dan Tafsir al-Maraghi adalah dua tafsir Al-Qur'an yang signifikan yang digunakan dalam penelitian ini untuk menganalisis beban ganda yang dihadapi perempuan dalam masyarakat. Tafsir al-Qurthubi, yang menggunakan pendekatan tradisional, menekankan peran penting perempuan dalam keluarga, seperti mendidik anak dan menjaga rumah tangga. Ia mengakui bahwa banyak perempuan mengalami kesulitan ketika harus menyeimbangkan tanggung jawab rumah tangga dengan keinginan untuk melakukan kontribusi di luar rumah. Sebaliknya, Tafsir al-Maraghi menawarkan perspektif yang lebih kontemporer dan progresif. Al-Maraghi menekankan betapa pentingnya mempertahankan hak-hak perempuan dan mendukung keadilan gender. Ia percaya bahwa perempuan memiliki potensi besar untuk berperan aktif dalam masyarakat dalam berbagai bidang sosial dan ekonomi, bukan hanya sebagai pengurus rumah tangga. Dia percaya bahwa perubahan sosial dan dukungan masyarakat dapat membantu perempuan mengatasi dua tantangan yang mereka hadapi. Studi ini menunjukkan bahwa, dengan membandingkan kedua tafsir ini, ada perbedaan yang signifikan dalam cara masing-masing tafsir memahami dan menawarkan solusi untuk masalah yang dihadapi perempuan. Hasil penelitian ini juga memberikan wawasan yang berharga untuk membangun pendekatan yang lebih adil dan mendukung perempuan di era modern, serta memperkuat pemahaman tentang pentingnya peran perempuan dalam kehidupan sosial dan keluarga. Fokus penelitian ini adalah untuk mendapatkan pemahaman tentang perspektif al-Qurthubi tentang perempuan dalam kaitannya dengan ayat-ayat yang berkaitan dengan perempuan, khususnya tentang kedudukan dan hak perempuan yang dibahas dalam kitab tafsir al-Qurthubi.
Cultura gastronómica y turismo. Resultado de investigación
Authors:   Universidad del Caribe, Yáñez Santamaría César , Flores Vega Ana Victoria , Domínguez Estrada José Francisco , Alanis Castro María Itzel , Jarillo Ibarra Eréndira Abigail , Morales Paredes Yesbek Rocío , Moreno Cortés Karla Coré , Morachis Valdez Ana Gabriela , Saucedo Vence Karinne , Santillán Álvarez Ángel , Dublán García Octavio , González Rodríguez Guillermo Isaac , Campos Medel Estela Mishelle , Toudert Djamel , Bringas Rábago Nora Leticia , Monroy Mercado Salvador , Thomé Ortiz Humberto , Gonzáles Domínguez Irais , Cedillo Velasco Maria de Jesús , Sevilla Borbón Jessica Citlalli , Borbón Alvarado Fabiola , Flores Ibarra Ana María , Zepeda Arce Alfonso , Berumen Calderón Mauro Felipe , Estolano Cristerna Damayanti , Sterling Zozoaga Angelica Selene , Molano Granados Ginna Soraya , Mazorco Salas Julio Eduardo , Amaya Molinar Carlos Mario , Velázquez Castro Judith Alejandra , Zepeda González César Iván , Novo Espinosa de los Monteros Gerardo , Rodríguez López Diana , Viesca González Carlos , Romero Contreras Alejandro Tonatiuh , Álvarez 	Trujillo Alejandro Manuel , Ramos Cruz Vicente Tadeo , Caballero Roque Adriana , Sánchez Ramírez Alondra Irene , Campos Mora Georgina , Domínguez Albiter Karla Isabel , Vargas Martínez Elva Esther , Sánchez 	Valdés Arlen , Amaro Parés Patricia
Published: January 2025

Con el objetivo de fomentar la difusión e investigación en gastronomía y turismo, el Cuerpo Académico Sistemas socioecológicos: Turismo y cultura gastronómica de la Universidad del Caribe, se exhortó a través de una convocatoria abierta a nivel nacional e internacional, a contribuir en la formación del libro Cultura Gastronómica y Turismo: Resultados de investigación.
Investigadoras e investigadores enviaron diversos textos que atendieron a las directrices señaladas y ejes rectores, abarcando áreas de aplicación como: Cultura y patrimonio, ciencia de los alimentos, servicios turísticos y gastronómicos, rutas turísticas gastronómicas, artes culinarias y administración. Los textos integraron investigaciones con resultados en tanto cuantitativos como cualitativos; así como avances en revisiones de literatura.
Mechanical characterization of intracellular drug transport based on optimization of chemical engineering principles
Authors: Cai Mingfan
Published: January 2025

At present, the measurement of cellular mechanical properties is divided into contact and non-contact, combined with the actual situation of the research in this paper, according to which the optical tweezers measurement technology in the non-contact type is adopted. Taking the measured value of cellular mechanical properties as the entry point of this research, the optimization method commonly used in chemical engineering principles was adopted, and the optimization model based on the separation of viscoelasticity parameters was set up by constantly changing the viscoelasticity parameters of intracellular transport of drugs and setting up certain criteria to optimize and obtain the viscoelasticity parameters that best represent the mechanical properties of intracellular transport of drug cells. The model was used to experimentally analyze the mechanical properties of intracellular drug transport. The deformation of drug cells when reaching the predetermined elastic force was small when transported with the optimized transport speed curve of parameter , and the transport speed was the largest, while the deformation obtained with the transport speed curve of parameter  was between the two, indicating that the optimized speed curve of viscoelasticity parameter can effectively reduce the mechanical damage of the drug cells in the process of transport.
Nghiên cứu điều kiện phản ứng Deacetyl hóa Glucomannan để sản xuất bún tươi giàu chất xơ, giá trị năng lượng cân đối từ bột Konjac Glucomannan và bột ngũ cốc
Authors:   Trường Đại học Y Dược Thái Bình, Thị Nữ Trần
Published: January 2025

Mục tiêu: Xây dựng quy trình sản xuất các loại bún giàu chất xơ, giá trị năng lượng cân đối từ bột Konjac glucomannan và bột ngũ cốc.
Phương pháp: Bột glucomannan và bột ngũ cốc. Khảo sát các điều kiện tối ưu cho phản ứng tạo gel từ glucomannan như tỷ lệ tác nhân phản ứng, nhiệt độ, thời gian phản ứng. Trộn hỗn hợp glucomannan đã deacetyl hóa và bột ngũ cốc theo tỷ lệ khác nhau. Thực hiện các bước theo quy trình sản xuất. Khảo sát các tính chất của sản phẩm thu được.
Kết quả: Xây dựng được quy trình sản xuất bún từ glucomannan và bột ngũ cốc ở điều kiện tối ưu mNaHCO3/glucomannan là 1,6%. Gia nhiệt ở 100oC và khuấy đều trong 7 phút, có hàm lượng chất xơ 4,23%, tổng năng lượng của 100g thành phẩm 154,35kcal, hàm lượng cacbohydrat 17,93%, lipid 5,91% và protein thực vật 7,36%.
Kết luận: Đã xác định được điều kiện tối ưu cho phản ứng deacetyl hóa glucomannan để sản xuất xuất bún tươi từ glucomannan và ngũ cốc. Sản phẩm tạo thành kết hợp được ưu điểm của glucomannan và ưu điểm của ngũ cốc vừa giàu chất xơ vừa có hàm lượng dinh dưỡng cân đối tốt cho sức khỏe con người.
Ca lâm sàng: diễn biến chẩn đoán và điều trị ca bệnh Wilson
Authors: Thanh Bình Vũ
Published: January 2025

Mục tiêu: Mô tả diễn biến quá trình chẩn đoán và điều trị ca bệnh Wilson.
Phương pháp: Đối tượng là 1 ca bệnh hiếm gặp, với chẩn đoán xác định là bệnh Wilson, phương pháp nghiên cứu: theo dõi diễn biến của người bệnh từ khi bắt đầu đến cơ sở y tế cho đến khi có chẩn đoán xác định cuối cùng và kết quả điều trị bệnh sau đó 2 tuần.
Kết quả: (theo dõi ca lâm sàng): Bệnh nhi nữ, 10 tuổi, với biểu hiện lâm sàng thỉnh thoảng có đợt mệt mỏi, chán ăn, đầy bụng, chướng hơi. Các triệu chứng này thường mất đi mà không điều trị gì. Đợt này đến khám do sốt, ho kèm theo có các triệu chứng trên. Dựa vào các kết quả xét nghiệm ban đầu, bệnh nhi được chẩn đoán viêm gan cấp do virus viêm gan E. Tuy nhiên qua nhiều tháng điều trị, men gan tăng dai dẳng, trên siêu âm có hình ảnh gan to, nhu mô tăng âm. Bệnh nhi được chỉ định xét nghiệm các marker viêm gan tự miễn, Ceruloplasmin, đồng niệu 24 giờ, soi đáy mắt, chụp MRI sọ não và phân tích gen. Kết quả chẩn đoán xác định bệnh nhi mắc bệnh Wilson với điểm Leipzig bằng 4. Sau 2 tuần điều trị bằng D-penicillamin, Trientine, kẽm và các Vitamin, bệnh nhi hết mệt mỏi, ăn uống được, đại tiểu tiện bình thường, siêu âm gan còn to, tuy nhiên kết quả xét nghiệm máu thấy men gan bình thường.
Kết luận: Bệnh Wilson là một bệnh hiếm gặp, cần chú ý tầm soát khi bệnh nhân có biểu hiện tại một hoặc nhiều trong 6 cơ quan: gan, thần kinh, thận, mắt, hồng cầu, xương khớp và tim mà không đáp ứng với điều trị theo chẩn đoán bệnh lý tại cơ quan này. Phát hiện sớm và điều trị kịp thời, bệnh cơ bản đáp ứng tốt.
A Critique of Yoruba Religio-cultural Belief in Reincarnation in Light of Hikmat al-Muta'āliya (Islamic Transcendent Philosophy)
Authors: Olawale Abdulwasi , Bakhshayesh Reza
Published: January 2025

Man's quest to understand life after death leads him to the concept of reincarnation. Reincarnation is the transmigration of human soul into another body. However, the African, especially the Yoruba concept of reincarnation is quite different from the Asian belief in certain aspects, and this is better explained in the three types of reincarnation common amongst them., viz: Ìpadàwáyé (ancestor’s rebirth), Àkúdáàya (reappearance after death) and Àbíkú (born to die). Even though few African philosophers have critiqued African’s reincarnation concept, but there persist unsatisfactory analysis and unanswered questions. This article, using descriptive-analytical method is unprecedented as it critiques Yorùbá's concept of reincarnation in light of Mulla Sadra's transcendent philosophy. Sadra's positions on the nature of Soul, substantial motion of the body and soul, etc., proved the impossibility of reincarnation of any form. Finally, this research also resolves other problems associated with Yorùbá's concept of reincarnation.