bluuebunny/crossref_metadata_2025 huggingface dataset:
CONSTRUCTION OF MODELS OF DATA ENVELOPMENT ANALYSIS (DEA) FOR DETERMINATION EFFECTIVENESS OF GOVERNMENT SOCIAL POLICY AT THE REGIONAL LEVEL
Authors:   O.M. Beketov National University of Urban Economy in Kharkiv, Rudachenko Olha , Klebanova Tamara ,   Simon Kuznets Kharkiv National University of Economics, Poluektova Nataliya ,   Agrotechnological Academy, V.I. Vernadsky Crimean Federal University
Published: April 2022

The article considers the problem of assessing the effectiveness of social policy at the regional level. The main problems caused by the Covid-19 pandemic have been studied. These include: an increase in the number of unemployed, the constant rise in prices for essential goods for consumption, the constant accumulation of non-payment for consumed housing and communal services, rising tariffs for urban transportation, delays in paying subsidies and financial assistance to low-income families. further can lead to social tension. These problems have been shown to be relevant because the government and other international agencies have not defined common approaches and rules for government regulation during a pandemic. The global coronavirus pandemic continues to this day. Therefore, it is important today to find methods that will allow us to analyze the effectiveness of measures taken at the level of regions of Ukraine. The study is conducted on the example of the Dnipropetrovsk region (GRP leader). The model proposed in the article makes it possible to assess the effectiveness of government decisions by comparing the impact of social indicators on gross regional product. The mathematical apparatus used in the article is Data Envelopment Analysis, DEA. This model, in our opinion, allows us to assess the effectiveness of management in very different in size and level of regions of the countries based on the identification of leading regions in terms of social development of the country. Based on the results of the study, it can be concluded that the proposed method of data shell analysis can be used as a tool to assess the Government's performance in terms of the effectiveness of the measures taken to achieve some strategic goals. The method allowed to show relative efficiency in comparison with results of activity of similar regions, considering influence of the social indicators expressed in various metrics. More specific conclusions can be drawn from the above data and used to improve systems of government regulation. This approach can be used at the state level, where the resulting value will be gross domestic product.
ENTERPRISE DEVELOPMENT TRENDS IN METALLURGICAL INDUSTRY OF UKRAINE
Authors:   O. Honchar National University of Dnipro, Bondarenko Natalia , Harakoz Lilya ,   O. Honchar National University of Dnipro
Published: April 2022

In the economy of Ukraine, the leading role is inherent in the industrial sector, which is a key factor in its socio-economic development. This branch of the national economy has the greatest multiplier effect on the economic system of our country and thus forms the basis for sustainable development of the state. As a result, the industry promotes business development. Among the industries an important place is occupied by metallurgical production. Creating a significant share of GDP and being a significant source of attracting foreign currency through exports, metallurgical enterprises provide the necessary raw materials for the engineering, transport and construction industries, contributing to the further development of the economy. However, in modern conditions, domestic metallurgical producers are not in all cases able to meet the challenges and obstacles associated with the global crisis, overproduction of ferrous metals, increasing number of competitors in world markets, deteriorating demand for metallurgical products, especially low quality. The article is devoted to the study of development trends of enterprises of the metallurgical industry of Ukraine in modern conditions. The paper analyzes the dynamics of Ukraine's GDP by type of economic activity and compares its share in the GDP of Ukraine and the countries that are members of the European Union; the number of business entities at the enterprises of the metallurgical industry of Ukraine in general and in terms of large, medium, small and micro enterprises is analyzed; the dynamics of the number of employees and the average salary are studied and the factors influencing them are clarified; the volumes of products sold by metallurgical enterprises, the results of their activities and the commodity structure of foreign trade in terms of types of products sold are analyzed. The analysis of the activity of the enterprises of the metallurgical industry of Ukraine testifies to the existence of a number of unresolved problems that require special attention, even in spite of the significant volumes and stable structure of foreign trade in the products of this branch of the national economy.
Corea y México: Dos estrategias de crecimiento con resultados dispares, José Antonio Romero y Julen Berasaluce, México, El Colegio de México, 2018, 403 pp.
Authors:   Universidad de Guadalajara, Jaen Jiménez Bernardo
Published: April 2022

In this book, Romero and Berasaluce address a crucial question: why has the Mexican economy had such a mediocre performance compared to the success that Korea has shown in the last 50 years? What kind of economic policies did the Korean government promote that allowed it to be part of the select group of developed countries, while Mexico remains underdeveloped? What was the role played by the Korean Government in leading the development of the economy and achieving higher levels of well-being for its population?
Los sitios de disposición final: una narrativa de los avances y las asignaturas pendientes en León, Guanajuato
Authors:   Universidad de Guanajuato, Tagle Zamora Daniel , Caldera Ortega Alex
Published: April 2022

Economic growth, population growth, consumer culture and the absence of environmen-tal education are factors that directly affect the increase in the volume of urban solid waste (msw) generated in cities. This dynamic represents a strong pressure for the municipalities, which, with scarce resources, they try to manage. The final disposal of msw, which is the center of interest of this proposal, constitutes the final process in the Integral Management of Solid Urban Waste, which is essential to avoid affecting health of the population and the environment. Therefore, the objective defined here was to determine the current condition of the final disposal sites (sdf) of msw in the third municipality with the largest population in Mexico: Leon, Guanajuato. Through qualitative research, which consisted of in-depth interviews with those responsible for managing the two sdf “El Verde” and “La Reserva,” it was possible to identify the progress made in the first, but also the pending subjects in the second, which can be complexly addressed, since it depends on political will and budgetary flexibility to harmonize in Leon a final provision in accordance with the regulations
Prospectiva Tecnológica: qué, dónde y cómo.
Authors: Pedroza Zapata Íkaro
Published: April 2022

En este artículo nos referimos a un ámbito especial de la prospectiva; el tecnológico, En este sentido, buscaremos contestar las siguientes preguntas: 1. ¿Qué es la prospectiva tecnológica? 2. ¿En dónde se hace prospectiva tecnológica y que resultado se ha obtenido? 3. ¿Qué herramientas se utilizan para hacer prospectiva tecnológica y donde se pueden obtener? Se entienden por prospectiva tecnológica las tentativas sistemáticas proyectadas y referidas al largo plazo, donde se toman en cuenta la evolución y los condicionamientos de la economía y la sociedad, por lo que los ejercicios de este tipo poseen un carácter multidisciplinar.
Estrategias didácticas y tecnología utilizada en la enseñanza de las ciencias. Una revisión sistemática
Authors: Zárate-Moedano Ramón , Canchola-Magdaleno Sandra Luz , Suarez-Medellín Jorge
Published: April 2022

El presente artículo muestra resultados de una revisión sistemática de literatura en torno a estrategias didácticas y experiencias de experimentación utilizadas en la enseñanza de las ciencias para analizar el aporte sobre la utilización de conceptos científicos modernos, el desarrollo de habilidades propias de la ciencia y la tecnología y la integración y solución de problemas y prácticas de laboratorio que faciliten el diálogo y la exposición de ideas propias, además de obtener información sobre las características deseables que deberían considerar las herramientas o dispositivos tecnológicos aplicados a la educación que favorezcan el desarrollo de habilidades científicas en los estudiantes. La conformación del corpus de estudio se realizó utilizando operadores booleanos lógicos en las bases de datos Scopus y Dialnet. Los criterios de agrupación-análisis fueron estrategias didácticas y laboratorio escolar o experiencias de experimentación. Los resultados muestran que las estrategias didácticas utilizadas sí abonan al desarrollo de habilidades científicas y conceptos básicos en ciencias. Las actividades de experimentación escolar basadas o no en tecnología como laboratorios virtuales, remotos o electrónicos facilitan la experiencia de indagación científica en la escuela teniendo como área de oportunidad incluir la solución de problemas.
Exchange Rate and Trade Balance in Nigeria: Testing for the Validity of J-Curve Phenomenon and Marshall-Lerner Condition
Authors: Duru Innocent U , Eze Millicent Adanne , Saleh Abubakar Sadiq , Yusuf Abubakar , Uzoma Kelechi
Published: April 2022

This study examined the validity of the J-Curve Phenomenon and Marshall-Lerner Condition in the Nigerian context using data from 1982-2020. The Autoregressive Distributed Lag Bounds test method of cointegration was employed for the analysis of short-run and long-run effects of exchange rate uncertainty on the trade balance. The long-run result endorsed the validity of the Marshall-Lerner Condition in Nigeria. Thus, a depreciation of the Naira improves the trade balance in the long run. However, the results of the short-run dynamics revealed that there is no J-Curve phenomenon in Nigeria. The study recommends diversification of exports to improve the performance of Nigeria’s non-oil exports. In addition, fiscal, monetary and exchange rate policies should be properly harmonized to tackle trade deficits. Furthermore, there should be more investment in Research and Development in Nigeria to improve the value of goods exported and the competitiveness of its exports in the arena of international trade.
Analisis Kualitas Produk Karet Ribbed Smoked Sheet menggunakan SQC dan FMEA
Authors: Chandrahadinata Dody , Taptajani Dedi Sa’dudin , Sa’bani Muhlis
Published: April 2022

Produk karet Ribbed Smoked Sheet (RSS) yang dihasilkan oleh PTPN VIII Kebun Mira Mare memiliki cacat produk pada proses penyaringan busa yang berupa cacat hasil karet menggelembung. Tingkat kecacatan yang ditoleransi adalah 1% sedangkan pada prosesnya melebihi batas yang telah ditentukan sehingga perlu diperbaiki agar tingkat kecacatatannya dapat menurun. Tujuan penelitian ini adalah untuk mengetahui faktor-faktor penyebab terjadinya cacat produk sehingga dapat menurunkan tingkat kecacatan pada proses penyarinang busa dengan memberikan usulan perbaikan dengan cara mereduksikan kecacatan dari proses penyaringan busa. Adapun pada penelitian ini menggunakan Statistical Quality Control (SQC) menggunakan 6 tahap antara lain check sheet, stratifikasi, histogram, pareto, peta proses operasi. Dan fishbone. Berdasarkan hasil penelitian, terdapat beberapa faktor yang mempengaruhi tingkat kecacatan pada proses penyaringan busa yaitu: mesin, material, manusia dan metode. Fault Mode and Effect Analysis (FMEA) dilakukan untuk memberikan usulan perbaikan dan memfokuskan evaluasi dalam proses penyaringan busa di PTPN VIII kebun Mira Mare. Dangan adanya penelitian ini, diharapkan dapat menyelesaikan permasalahan tersebut serta dapat menentukan usulan perbaikan sehingga bisa membantu pihak perusahaan untuk menurunkan tingkat cacat pada saat proses penyaringan busa.
Long-Term Management of Seizures after Surgical Treatment of Supratentorial Cavernous Malformations : A Retrospective Single Centre Study
Authors: Dziedzic Tomasz A. , Koczyk Kacper , Nowak Arkadiusz , Maj Edyta , Marchel Andrzej
Published: April 2022

Objective : Seizure recurrence after the first-ever seizure in patients with a supratentorial cerebral cavernous malformation (CCM) is almost certain, so the diagnosis and treatment of epilepsy is justified. The optimal method of management of these patients is still a matter of debate. The aim of our study was to identify factors associated with postoperative seizure control and assess the surgical morbidity rate.Methods : We retrospectively analysed 45 consecutive patients with a supratentorial CCM and symptomatic epilepsy in a single centre. Pre- and postoperative epidemiological data, seizure-related patient histories, neuroimaging results, surgery details and outcomes were obtained from hospital medical records. Seizure outcomes were assessed at least 12 months after surgery.Results : Thirty-five patients (77.8%) were seizure free at the long-term follow-up (Engel class I); six (13,3%) had rare, nocturnal seizures (Engel class II); and four (8.9%) showed meaningful improvement (Engel class III). In 15 patients (33%) in the Engel I group; it was possible to discontinue antiepileptic medication. Although there was not statistical significance, our results suggest that patients can benefit from early surgery. No deaths occurred in our study, and mild postoperative neurologic deficits were observed in two patients (4%) at the long-term follow-up.Conclusion : Surgical resection of CCMs should be considered in all patients with a supratentorial malformation and epilepsy due to the favourable surgical results in terms of the epileptic seizure control rate and low postoperative morbidity risk, despite the use of different predictors for the seizure outcome.
EFFECTIVE BLENDED LEARNING IN HIGHER EDUCATION DURING COVID-19
Authors: Sankar Jayendira P. , Kalaichelvi R. , Elumalai Kesavan Vadakalur , Alqahtani Mufleh Salem M.
Published: April 2022

The COVID-19 pandemic situation has impacted the entire education system, especially universities, and brought a new phase in education, “blended learning.” The objective of the research was to study the relationship of eight independent factors: e-learning environment, e-learning facilitation, e-learning materials, e-learning technical support, instructors’ personal attention, interaction with instructors, interaction with peer students, and laboratory learning environment, in the provision of effective blended learning in higher education during COVID-19 pandemic. Additionally, an extended relationship of gender and level of course with the effective blended learning was studied. A descriptive cross-sectional study was conducted with the students of higher education institutions in the Kingdom of Bahrain, and the Kingdom of Saudi Arabia, with a self-administered questionnaire aimed to learn the students’ perception of blended learning. All levels of undergraduate and postgraduate students took part in the study with a sample size of 1229. Ultimately, this study used a Structural Equation Modelling (SEM) approach to find the positive relationship between the effective blended learning and the eight independent variables and two mediating variables in the higher education sector. The study results portrayed a positive relationship between the eight independent variables and blended learning effectiveness in higher education institutions. The findings revealed that there is a difference in the students' perception of gender, level of the course, and the effectiveness of blended learning in the HEIs. The research offers guidance to governing bodies, administrators, and teachers of HEIs in decision-making and improves their actions to provide the best teaching and learning through blended learning. HEIs need to focus on the study results to enhance blended learning effectiveness based on e-learning environment, e-learning facilitation, e-learning materials, e-learning technical support, instructors’ personal attention, interaction with instructors, interaction with peer students, and laboratory learning environment. Also, since there is a significant difference between the gender, level of the course, and blended learning, providing blended learning based on gender and level of the course needs to be concentrated on by the higher education institutions.
ТИПОЛОГІЯ ІНТЕРНЕТ-РЕСУРСІВ ДЛЯ РОЗВИТКУ ІНФОМЕДІЙНОЇ ГРАМОТНОСТІ МОЛОДІ
Authors: Друшляк Марина Григорівна , Семеног Олена Миколаївна , Грона Наталія Вікторівна , Пономаренко Наталія Петрівна , Семеніхіна Олена Володимирівна
Published: April 2022

У статті схарактеризовано типологію електронних ресурсів у галузі медіаосвіти, визначено типи електронних ресурсів, які можуть бути успішними для розвитку інфомедійної грамотності учнівської та студентської молоді, проведено експертну оцінку ефективності типів електронних ресурсів для формування інфомедійної грамотності. Медіаосвіту схарактеризовано як процес навчання і самонавчання за посередництва медіа, як науково-освітню сферу діяльності, що спрямована на формування психологічного захисту від маніпуляцій та формування медіаграмотності особистості. Показано, що інфомедійна грамотність характеризується набором маркерів: медіаграмотність, критичне мислення, соціальна толерантність, стійкість до впливів, фактчекінг, інформаційна грамотність, цифрова безпека, уміння запобігати ризикам у комунікації, візуальна грамотність; уміння втілювати ідеї завдяки онлайн-інструментам, уміння використовувати медіа для соціального блага. Обґрунтовано, що розвитку інфомедійної грамотності значною мірою сприяють Інтернет-ресурси. Проведений аналіз електронних освітніх ресурсів у мережі Інтернет уможливив їх класифікацію: відеоконтент (вебінари, освітні серіали, медіатексти, ютуб-канали тощо); аудіоконтент (подкасти); освітні платформи (Prometheus, Ed-Era, IREX, 4mamа та подібні до них); текстові ресурси (онлайн посібники, е-словники тощо); креолізовані ресурси (комікси, дудли, постери, інфографіка тощо); ігровий контент (онлайн ігри); соціальні мережі й дискусійні Інтернет-майданчики; спеціалізовані науково-популярні сайти (сайти наукових лабораторій, громадських організацій; сайти, створені при університетах тощо). Проведено експертну оцінку ступеня потенційного впливу Інтернет-ресурсів на розвиток інфомедійної грамотності. За результатами експертної оцінки найбільш ефективно впливають на розвиток кількості маркерів інфомедійної грамотності освітні платформи (Prometheus, Ed-Era, IREX, 4mamа та подібні до них), відеоконтент (вебінари, освітні серіали, ютуб-канали тощо) і текстові ресурси (онлайн посібники, е-словники тощо).
MOBILE TECHNOLOGIES IN THE DEVELOPMENT OF PROFESSIONALLY ORIENTED ENGLISH SPEECH INTERACTION COMPETENCE IN INFORMATION SYSTEMS AND TECHNOLOGY MILITARY STUDENTS
Authors: Maiier Nataliia V. , Yukhymenko Violetta O.
Published: April 2022

The purpose of learning a foreign language by future information systems and technology officers is the development of practical skills to the extent that is necessary for communication in various professional situations. The intensive integration of mobile technologies into the higher education system encourages research of the challenges of their use for the development of professionally oriented English speech interaction competence in future information systems and technology officers. The study describes the officers' survey results regarding their needs in professional foreign language communication. It analyzes the use of mobile technologies (the uniquely designed mobile application "English Speaking Skills", the YouTube channel "Military Speaking Skills in Use" and the group chat "English Speaking" in the Telegram mobile messenger) during experimental training in professionally oriented English communication conducted for information systems and technology cadets and officers from a higher military education institution. The study showed that a specially created mobile learning environment for the development of professionally oriented English speech interaction competence in future information systems and technology officers provides opportunities for interactive communication between all participants of the educational process. It develops speech skills and increases the effectiveness of mastering the specific terminology of the military industry. Further use of mobile technologies (didactic educational material) can facilitate the perception of new information in English, motivate to study, and become a learning tool for the development of practical speech skills in the process of verbal and nonverbal communication of information systems and technology cadets with native speakers.
Diseño de Redes de Transporte mediante una variante del Modelo Physarum
Authors: Cortínez Víctor Hugo , Dominguez Patricia Neri
Published: April 2022

Se considera el problema del diseño de redes de transporte, conociendo la topología factible y la matriz origen-destino de viajes. El objetivo de este trabajo es obtener las capacidades de los tramos de la red que permiten satisfacer las demandas de pasajeros (o vehículos), minimizando tanto sus recorridos de viaje como el costo de construcción. Para ello, se propone un modelo matemático, basado en una analogía con el comportamiento de aprovisionamiento de un organismo biológico (Physarum Polycephalum), consistente en un procedimiento iterativo que converge al denominado “óptimo del sistema” de transporte.Adicionalmente, se combina esta metodología con una técnica de reducción de variables, basada en el “Método de Elementos Finitos” para minimizar el tiempo de cálculo computacional requerido al analizar grandes redes.
SCIENTIFIC STUDIES ON THE EFFECTS OF THE CHANGES IN TREATMENT PROCESSES DURING THE COVID-19 PANDEMIC ON INFERTILE COUPLES: LITERATURE REVIEW
Authors: DURGUN OZAN Yeter , DİNÇER Sümbül
Published: April 2022

Abstract: The COVID-19 pandemic has been rapidly raging. Suspending the services related to infertility and assisted reproductive techniques are among the measures taken to prevent the spread of the epidemic. Various guides and recommendations have been published by many national and international associations for this purpose. Recommendations foresee the completion of cycles that have already been initiated and require no new reproductive therapies to be initiated except for patients with low ovarian reserve and those with a background of oncological disorders. The majority of couples whose treatment is suspended/postponed throughout this process have experienced intense stress, sadness and anxiety. In addition, some of the patients do not have adequate coping skills. This article is designated as a literature review in order to provide information about the current emotional states of infertile couples throughout the COVID-19 pandemic and to guide the studies planned for their needs. Due to the fact that the subject is related to the pandemic, the years covered by the literature review were limited to 2019 and later. As a result of the literature review; 2 studies conducted in Turkey and 5 studies conducted abroad, examining the effects of COVID-19 on infertile couples, were included. Majority of studies revealed that suspending fertility treatments caused high levels of anxiety and stress in infertile couples. Providing psychological counseling services to couples through online platforms by health professionals is thought to enable couples to cope better with the situation.
An Empirical Assessment of Insecurity and The Socio-Economic Living Standard of the People of Orlu, Imo State
Authors: , I. S Austin-Egole , , E.B.J. Iheriohanma , F. O. Egwim,
Published: April 2022

Insecurity is currently a recurrent issue in many countries of the world - developed and developing. In Nigeria, it has multifaceted manifestations such as Boko Haram terror attacks, banditry/kidnapping, herdsmen/farmers clashes, religious tensions, secessionist movements, agitations for resource control, piracy, organized crime, etc. Recently, the level of insecurity in Imo State has become alarming with several reported regular occurrences of shooting in the area involving unknown gunmen, bandits, and security operatives - a situation which is undoubtedly affecting both social life and the local economy. This paper, therefore, sought to investigate to what extent the socio-economic living standard of the people of Orlu Imo State, Nigeria has been adversely affected by the insecurity situation currently ravaging the area. The investigation mainly covered 2018 and 2022. The survey research design used questionnaires and interviews as instruments of primary data collection were used for the study. Frustration-Aggression Theory served as the theoretical framework. Data were analyzed with simple percentages while the chi-square was used to test the hypothesis. Secondary data from library research was utilized for analytical discussion. Research findings showed that insecurity adversely affected the socio-economic living standard of people as the situation forced residents to be indoors and businesses and social activities ground to a halt. It is recommended that dialogue and round table discussion be made to urgently find a lasting solution to the insecurity situation because the residents are bearing the brunt of the suffering.
Black College Students Undermining the Power of Social Media When Preparing for The Competitive Job Market: Gap in Curriculums
Authors: Young, DBA Dr. Tia
Published: April 2022

This study explores why Black college students are not utilizing social media to prepare for career advancement after graduation. The research suggests students are oblivious to how using it irresponsibly can impact careers. The issue is vital because; 1) There is a disparity of Blacks getting access to white-collar jobs despite having a degree, 2) Recruiters use social media to weed out prospects, and 3) There is a gap in college curriculums that fail to teach students to brand themselves professionally. The sample was one hundred Bowie State University students, instrumentation was an open-end survey, and the framework was empirical probability.
Case Study Methods with English Using as Foreign Language to Teach Students with Social Sciences & Law Majors-A Case of Publishing Untruth Information of Some Vietnam Newspapers from Korean and China Laws Approach
Authors: Hoa, PhD Le Huong , Huy, MBA Dinh Tran Ngoc , Toan Le Vu Linh , Ngoc Hien Dinh Tran
Published: April 2022

More And More Educators and Teachers in Colleges and Universities Consider Using Case Study Methods with Using English to Teach Students in Advanced Programs with Social Sciences, Law, Or Journalism Majors.
Therefore, To Improve Teaching Quality, The Authors Will Present a Case of Using English as A Foreign Language Via a Case of Publishing Untruth Information of Some Vietnam Newspapers (Thanhnien. Vn and Tuoitre. Vn - Online Magazines in Vietnam) From Korean and China Laws Approach.There Are Ideas to Solve This Issue Even Using Criminal Act Law as They Will Cause Bad Effects Including Disinformation, Disorder, And Misleading Community and Society.
As Usual, We Will Teach Students About the Approaches of President Ho Chi Minh On Publishing Activities.
Defining Corporate Values to Signal Functionality in Stakeholder Communication
Authors: Frecè* Jan T. , Harder Deane
Published: April 2022

Many corporations define values and publish them in their yearly reports or on their websites. Managers see the benefit of having corporate values. This article critically evaluates the idea of corporate values and presents a set of criteria that functional corporate values should meet. We will show how corporate values contribute to the identity of a company and signal its identity to society, thus providing a base for its “license to operate”. This concept of corporate values was assessed empirically with the self-stated values of 50 Swiss companies. We show that many companies have an insufficient concept of corporate values and, if stated at all, they are in many cases dysfunctional. It can be concluded that there is a knowing-doing gap but also a pronounced lack of knowledge regarding corporate values. More research is recommended to address the perception of the function of values from a managerial point of view.
Different methods of professional oral hygiene. Literature review
Authors: Thabet M. A. K. , Razumova S. N. , Brago A. S. , Filimonova O. V. , Rebriy A. V. , Adzhieva E. V.
Published: April 2022

Relevance. The problem of the effectiveness of oral hygiene is currently relevant due to the introduction of new tools and methods of Prophylaxis hygiene.

Objective. The aim of this study is to Conduct a literature review from different database on modern methods of professional oral hygiene using the keywords: air polishing; glycine; sodium bicarbonate; dental caries; alternative methods, air abrasive. To study different literature sources on the effectiveness of using modern air-abrasive procedures for professional hygiene.

Methods. Electronic databases PubMed, eLibrary were screened. Selected studies that investigate the efficacy of various professional hygiene practices and their effects on the state of the oral cavity.

Results. By keywords, 1345 abstracts were found that cover the results of scaling – 544, polishing – 704, remineralization – 97. 24 were included in the analysis on various methods of oral hygiene, taking into account the state of hard and soft tissues when using air-abrasive polishing.

Conclusion. Data confirms the variety of professional oral hygiene methods used and the efficacy of their results. Studies on the impact of various procedures of curette, scaling, and polishing on tooth tissues have shown conflicting findings. More research into the efficacy of professional oral hygiene practices is required.
Analysis of monitoring and routing of patients with lichen planus of the oral mucosa according to a questionnaire of doctors
Authors: Shkarin V. V. , Makedonova Yu. A. , Dyachenko S. V. , Gavrikova L. M. , Dyachenko D. Yu.
Published: April 2022

The greatest increase in the frequency of occurrence was noted among diseases of the oral mucosa, especially lichen planus (LP). This dictates the need to study the features of LP monitoring and routing of patient data. Currently, the national project «Healthcare» implies, in addition to the main medical federal projects, organizational and digital directions for the development of the Russian Federation. The purpose of the study is to conduct a sociological study of monitoring and routing of patients with lichen planus of the oral mucosa. Materials and methods. To achieve this goal, an anonymous survey of 287 dentists was conducted on the provision of dental therapeutic care to patients with LP SP using a questionnaire developed by us, consisting of 35 questions of clinical, organizational and social aspects. Results and discussion. Specialist doctors noted the need to consult patients using telemedicine technologies, to create an objective way to monitor the pathological process in LP. Conclusion. Dental treatment, aimed not only at eliminating symptomatic factors, but also carried out from the standpoint of preventive medicine, is one of the urgent tasks today. Dentists are acutely aware of the lack of computerized methods for monitoring and routing patients with LP SBP, which should be the goal of the developed medical complexes.
Invasive cervical resorption as a complication of intracoronal bleaching
Authors: Pankratjeva E. P. , Afanasenko V. A. , Kunavinа K. A. , Gagarina T. Yu. , Shilovskya K. A.
Published: April 2022

The article is devoted to invasive cervical resorption (ICR) as a complication of intracoronal bleaching. The purpose of the review: to analyze the available information on ICR according to domestic and foreign literature sources with the study of the mechanisms of the negative effect of dental materials for intracoronal bleaching on the dentin and cementum of the tooth root; processes of occurrence of ICR; properties that restorative products must have to combat this complication. In the course of the study, aggravating factors were identified, which are orthodontic treatment, trauma, dentoalveolar surgery, defects in the development of hard dental tissues. It has been determined that the mechanism of the negative effect of preparations for intracoronal bleaching on dentin and cementum of the tooth root is the process of free radical release. It was revealed that today, the mineral trioxide aggregate (MTA) is the only restorative material that suppresses osteoclastic activity, on the surface of which cementogenesis can occur.
Study of the profile of the soft tissues of the face, taking into account the individual typological features of the dental arches
Authors: Kochkonyan T. S. , Shkarin V. V. , Domenyuk D. A. , Dmitrienko S. V. , Domenyuk S. D.
Published: April 2022

Based on the results of the analysis of profile photostatic images of 96 people aged 18–25 years with physiological types of bite, the main anthropometric landmarks were determined and the position of the lips relative to the nasal line passing through the “n” point (nasion) and the “sn” point (subnasale) was studied. Depending on the size of the interincisal angle of the antagonistic medial incisors, which determine whether they belong to the trusive type of dental arches, patients were divided into three groups with mesotrusion (n=37), protrusive (n=34) and retrusion (n=25) types of dental arches. It was found that in almost all patients of the first group, the upper lip touches the nasal line, and the lower lip recedes slightly backwards, while the average value of the incisal angle is 135.24±3.09°. In most patients of the second group, the upper and lower lips are located anterior to the nasal line, and the average inter-incisal angle is 116.24±3.02°. Mostly in patients of the third group, the upper and lower lips were located behind the nasal line, and the average values of the incisal angle were 146.24±3.34°. The data obtained expand the understanding of the topography of the facies contour of the upper and lower lips with various types of dental arches, are of applied importance for assessing the harmony of the aesthetic profile of the soft tissues of the face, and are also criteria for the effectiveness of the rehabilitation of patients with dentoalveolar pathology, taking into account the individual characteristics of the maxillofacial region.
REMOVAL OF HEAVY METALS FROM WASTEWATER BY USING PHYTOREMEDIATION TECHNOLOGY
Authors: Balamoorthy Dhivya , Velusamy Prabu , Rath Badrinarayan , T R Praveenkumar , Kabeto Julla
Published: April 2022

Contamination of soil and water by toxic metals is a major environmental hazard. The removal of heavy metals from wastewater by chemical methods is very costly and does not apply to the pretreatment process. Hence, phytoremediation process is one of the simplest methods to restore polluted environments. The present research paper investigates the potential of Mimosa Pudica for bio removal of heavy metals like Cd, Pb and Cu from wastewater by using phytoremediation or bioremediation technology. Heavy Metals were detected before and after the process using Atomic Adsorption Spectrometer (AAS). The synthetic wastewater contains Cd, Pb, and Cu at an initial concentration of 0.25mg/l, 0.5mg/l, and 2mg/l was introduced to the soil mass planted by Mimosa Pudica and treated for 16 days through their root. Collected samples were taken for laboratory analysis. The result showed that there was a reduction in Cd, Pb and Cu at a concentration of 0.02mg/l, 0.21mg/l, and 0.4mg/l level of heavy metals from the wastewater. After that, investigation of the potential of Mimosa Pudica accumulates up to 92% of Cd, 58 % of Pb, and 80% of Cu. The evidence presented by this study specified that Mimosa Pudica is an efficient accumulator plant for phytoremediation or bioremediation.
A Final Cure to the Tribulations of the Vacuum in Quantum Theory
Authors: Jean-Claude Joseph
Published: April 2022

Quantum Field Theory has seemingly been of late anything but unraveling. Undeniably, for many different reasons there is a rampant discomfort with the Standard Model as a complementing extension of QFT. Prior to the recent supersymmetry upset, the “vacuum catastrophe” or “cosmological constant problem” shook the very foundations of QFT. Effectively the enormous numeric disparity between its predicted value of the vacuum energy density, and the measured value from a Relativistic approach has been qualified by some as the biggest predictive failure of any Theory. QFT has been left searching for its soul now for almost two decades. Under the umbrella of Quanto-Geometric Theory, we offer a different approach to the problem which successfully calculates a sensible and consistent value of the vacuum energy density from first axiomatic principles, casting a close match with the cosmological quantity, thereby bridging the grueling gap between the quantum vacuum and the relativistic vacuum.
Extraterrestrial Nature Reserves
Authors: Smith Paul
Published: April 2022

Terraforming Mars requires establishment of essential, ecosystem services on a planet currently unamenable to Terran species. Shorter term, assembling Terran-type ecosystems within contained environments is conceivable. An assemblage of organisms that might form an early, forest environment is proposed, with rationale for its selection. A case is made for establishment of a contained facsimile, old growth forest on Mars, providing an oasis, proffering vital ecosystem functions. It would serve as an extraterrestrial nature reserve, psychological refuge and utilitarian botanic garden, supporting species of value to colonists for secondary metabolites, substances otherwise requiring freighting or in-situ manufacture. The design presented includes organisms that might tolerate local environmental variance and be assembled into a novel, bioregenerative forest ecosystem. This would differ from Earthly forests due to the potential impact of local abiotic parameters on ecosystem functions, but it is argued that biotic support for space travel and colonization requires such developments.
From Theology And Philosophy To Psychology In The West
Authors: Riddell Rachel
Published: April 2022

This study aims to explore the Western epistemological shift over the last five hundred years: a move from Christianity to secularism. To do this, we will address key philosophical, theological and psychological developments and their respective proponents in history. We will also note the consequences of these ideas on broader human society. We will approach this topic from a Biblical epistemological foundation, allowing our faith in God to guide our interpretation of these developments. This article is divided into five key sections, each addressing the concerns of different ages in history. We discover that relativism is what binds all of these ages and developments together.
Sex Differences in Airway Remodeling and Inflammation: Clinical and Biological Factors
Authors: Ekpruke Carolyn Damilola , Silveyra Patricia
Published: April 2022

Asthma is characterized by an increase in the contraction and inflammation of airway muscles, resulting in airflow obstruction. The prevalence of asthma is lower in females than in males until the start of puberty, and higher in adult women than men. This sex disparity and switch at the onset of puberty has been an object of debate among many researchers. Hence, in this review, we have summarized these observations to pinpoint areas needing more research work and to provide better sex-specific diagnosis and management of asthma. While some researchers have attributed it to the anatomical and physiological differences in the male and female respiratory systems, the influences of hormonal interplay after puberty have also been stressed. Other hormones such as leptin have been linked to the sex differences in asthma in both obese and non-obese patients. Recently, many scientists have also demonstrated the influence of the sex-specific genomic framework as a key player, and others have linked it to environmental, social lifestyle, and occupational exposures. The majority of studies concluded that adult men are less susceptible to developing asthma than women and that women display more severe forms of the disease. Therefore, the understanding of the roles played by sex- and gender-specific factors, and the biological mechanisms involved will help develop novel and more accurate diagnostic and therapeutic plans for sex-specific asthma management.
A CHO-Based Cell-Free Dual Fluorescence Reporter System for the Straightforward Assessment of Amber Suppression and scFv Functionality
Authors: Krebs Simon K. , Rakotoarinoro Nathanaël , Stech Marlitt , Zemella Anne , Kubick Stefan
Published: April 2022

Incorporation of noncanonical amino acids (ncAAs) with bioorthogonal reactive groups by amber suppression allows the generation of synthetic proteins with desired novel properties. Such modified molecules are in high demand for basic research and therapeutic applications such as cancer treatment and in vivo imaging. The positioning of the ncAA-responsive codon within the protein’s coding sequence is critical in order to maintain protein function, achieve high yields of ncAA-containing protein, and allow effective conjugation. Cell-free ncAA incorporation is of particular interest due to the open nature of cell-free systems and their concurrent ease of manipulation. In this study, we report a straightforward workflow to inquire ncAA positions in regard to incorporation efficiency and protein functionality in a Chinese hamster ovary (CHO) cell-free system. As a model, the well-established orthogonal translation components Escherichia coli tyrosyl-tRNA synthetase (TyrRS) and tRNATyrCUA were used to site-specifically incorporate the ncAA p-azido-l-phenylalanine (AzF) in response to UAG codons. A total of seven ncAA sites within an anti-epidermal growth factor receptor (EGFR) single-chain variable fragment (scFv) N-terminally fused to the red fluorescent protein mRFP1 and C-terminally fused to the green fluorescent protein sfGFP were investigated for ncAA incorporation efficiency and impact on antigen binding. The characterized cell-free dual fluorescence reporter system allows screening for ncAA incorporation sites with high incorporation efficiency that maintain protein activity. It is parallelizable, scalable, and easy to operate. We propose that the established CHO-based cell-free dual fluorescence reporter system can be of particular interest for the development of antibody-drug conjugates (ADCs).
Lessons for Remote Post-earthquake Reconnaissance from the 14 August 2021 Haiti Earthquake
Authors: Whitworth Michael R. Z. , Giardina Giorgia , Penney Camilla , Di Sarno Luigi , Adams Keith , Kijewski-Correa Tracy , Black Jacob , Foroughnia Fatemeh , Macchiarulo Valentina , Milillo Pietro , Ojaghi Mobin , Orfeo Alessandra , Pugliese Francesco , Dönmez Kökcan , Aktas Yasemin D. , Macabuag Josh
Published: April 2022

On 14th August 2021, a magnitude 7.2 earthquake struck the Tiburon Peninsula in the Caribbean nation of Haiti, approximately 150 km west of the capital Port-au-Prince. Aftershocks up to moment magnitude 5.7 followed and over 1,000 landslides were triggered. These events led to over 2,000 fatalities, 15,000 injuries and more than 137,000 structural failures. The economic impact is of the order of US$1.6 billion. The on-going Covid pandemic and a complex political and security situation in Haiti meant that deploying earthquake engineers from the UK to assess structural damage and identify lessons for future building construction was impractical. Instead, the Earthquake Engineering Field Investigation Team (EEFIT) carried out a hybrid mission, modelled on the previous EEFIT Aegean Mission of 2020. The objectives were: to use open-source information, particularly remote sensing data such as InSAR and Optical/Multispectral imagery, to characterise the earthquake and associated hazards; to understand the observed strong ground motions and compare these to existing seismic codes; to undertake remote structural damage assessments, and to evaluate the applicability of the techniques used for future post-disaster assessments. Remote structural damage assessments were conducted in collaboration with the Structural Extreme Events Reconnaissance (StEER) team, who mobilised a group of local non-experts to rapidly record building damage. The EEFIT team undertook damage assessment for over 2,000 buildings comprising schools, hospitals, churches and housing to investigate the impact of the earthquake on building typologies in Haiti. This paper summarises the mission setup and findings, and discusses the benefits, and difficulties, encountered during this hybrid reconnaissance mission.
MIP From Legionella pneumophila Influences the Phagocytosis and Chemotaxis of RAW264.7 Macrophages by Regulating the lncRNA GAS5/miR-21/SOCS6 Axis
Authors: Shen Youfeng , Xu Jian , Zhi Shenshen , Wu Wenyan , Chen Yingying , Zhang Qiang , Zhou Yan , Deng Ze , Li Wei
Published: April 2022

Background

The intracellular pathogen Legionella pneumophila (L. pneumophila) is a causative agent of pneumonia and does great harm to human health. These bacteria are phagocytosed by alveolar macrophages and survive to replicate within the macrophages. Despite macrophage infectivity potentiator (MIP) protein serving as an essential virulence factor during the invasion process of L. pneumophila, the regulatory mechanism of MIP protein in the process of bacterial infection to host cells is not yet completely understood. This research thus aims to explore the interaction between MIP and macrophage phagocytosis.

Methods

Through the experiment of the co-culture of RAW264.7 macrophages with different concentrations of MIP, the chemotactic activity of macrophages was detected and the phagocytosis was determined by a neutral red uptake assay. The expression of long noncoding RNA (lncRNA) GAS5, microRNA-21 (miR-21), and suppressor of cytokine signaling (SOCS)6 was determined by qRT-PCR. Target genes were detected by dual luciferase assay.

Results

MIP could reduce the phagocytosis and improve the chemotaxis of RAW264.7 macrophages. The expression of both lncRNA GAS5 and SOCS6 was increased whereas the expression of miR-21 was decreased when macrophages were treated with MIP. Dual luciferase assay revealed that lncRNA GAS5 could interact with miR-21, and SOCS6 served as the target of miR-21. After GAS5 overexpression, the phagocytosis of RAW264.7 treated with MIP was increased whereas the chemotaxis was decreased. In contrast, the opposite results were found in RAW264.7 following GAS5 interference.

Conclusions

The present results revealed that MIP could influence RAW264.7 macrophages on phagocytic and chemotactic activities through the axis of lncRNA GAS5/miR-21/SOCS6.
Aptamer-Targeted Drug Delivery for Staphylococcus aureus Biofilm
Authors: Ommen Pernille , Hansen Line , Hansen Bente K. , Vu-Quang Hieu , Kjems Jørgen , Meyer Rikke L.
Published: April 2022

Treatment of Staphylococcus aureus biofilm infections using conventional antibiotic therapy is challenging as only doses that are sublethal to the biofilm can be administered safely to patients. A potential solution to this challenge is targeted drug delivery. In this study, we tailored an aptamer-targeted liposomal drug delivery system for accumulation and delivery of antibiotics locally in S. aureus biofilm. In our search for a suitable targeting ligand, we identified six DNA aptamers that bound to S. aureus cells in biofilms, and we demonstrated that one of these aptamers could facilitate accumulation of liposomes around S. aureus cells inside the biofilm. Aptamer-targeted liposomes encapsulating a combination of vancomycin and rifampicin were able to eradicate S. aureus biofilm upon 24 h of treatment in vitro. Our results point to that aptamer-targeted drug delivery of antibiotics is a potential new strategy for treatment of S. aureus biofilm infections.