bluuebunny/crossref_metadata_2025 huggingface dataset:
Immunoexpression of CD44, p16 and VEGF in oral cancer
Authors: de Abreu Priscila Marinho , Sol Marcella , Bianchi Molini Patrícia Roccon , Daniel Camila Batista , Camisasca Danielle Resende , von Zeidler Sandra Ventorin
Published: July 2024

Objectives:

The aim of the present study was to examine the immunoexpression of CD44, p16 and VEGF in oral squamous cell carcinoma (OSCC) and correlate them to clinicopathological parameters and survival outcomes in order to clarify their prognostic impact.

Material and Methods:

A total of 68 individuals with OSCC recruited between 2011 and 2015 from two referral centres were enrolled in the study. The samples were placed on silanized glass slides and subjected to immunohistochemistry using anti-p16, anti-CD44 and anti-VEGF antibodies. The H Score was used for p16 and VEGF, while CD44 was scored according to the percentage of stained cells. Chi-square tests and Fisher’s exact probability tests were used to compare clinicopathological characteristics according to the immunohistochemical expression, while overall survival and disease-free survival were estimated and compared using the Kaplan-Meier method and log-rank test, respectively. For all hypothesis tests, the level of significance was set at P ≤ 0.05.

Results:

No correlation was observed between the expression of tumour VEGF, p16 and CD44, and the clinicopathological characteristics analysed. Patients with high stromal VEGF expression had better disease-free survival than patients with low VEGF expression (P = 0.023).

Conclusion:

In summary, P16, CD44 and tumour VEGF did not prove to be good prognostic biomarkers. Stromal VEGF expression is suggested to be a good candidate prognostic biomarker, although additional studies are needed.
Associations between Driving Status, Frequency of Transport use after Driving Cessation, and Social Frailty among Middle-Aged and Older Adults
Authors: Fukuei Tatsuya , Akaida Shoma , Taniguchi Yoshiaki , Shiratsuchi Daijo , Kiuchi Yuto , Tateishi Mana , Aishita Yukari , Kuratsu Ryota , Makizako Hyuma
Published: July 2024

Background: The use of transport other than cars is a modifiable factor in the association between driving cessation and social frailty. Clarifying this relationship may serve as a new preventive measure against social frailty among current non-drivers. This study examined the potential association of driving status and transport use with social frailty, as well as between the frequency of transport use and social frailty, among current non-drivers.Methods: This study included 977 middle-aged and older adults (average age, 65.3±4.8 years). The participants were classified as transport users (more than a few times a week) and transport non-users (less than a few times a month). Based on driving status and transport use, the groups were further classified into current driver, current non-driver/transport user, and current non-driver/transport non-user groups. The relationships between driving status, transport use, and social frailty were examined using multiple logistic regression.Results: The current non-driver group and the transport non-user group were significant association with a higher social frailty. The current non-driver/transport user group showed no association with social frailty compared with the current driver group. The odds ratio for the social frailty rate for The current non-driver/transport non-user group was 2.14 (95% confidence interval, 1.25–3.73).Conclusions: Participants who neither drive nor take transport showed significant associations with increased social frailty. Compared with current driver/transport use, current non-driver/transport non-use was associated with social frailty.
Follow-Up of Cardiopulmonary Responses Using Submaximal Exercise Test in Older Adults with Post-COVID-19
Authors: Amput Patchareeya , Wongphon Sirima
Published: July 2024

Background: Data on cardiopulmonary fitness in older adults in the longer term after coronavirus disease 2019 (COVID-19) are of interest as the time required for the full recovery of physical fitness after COVID-19 remains unclear. Some studies have reported that patients do not recover physical fitness for up to 6 or 12 months after COVID-19, whereas other studies have observed full recovery after 12-months. Therefore, this study evaluated and compared the cardiopulmonary responses induced by the 6-minute walk test (6MWT) and 1-minute sit-to-stand-test (1-min-STST) results at 3, 6, and 12 months in older adults with and without COVID-19. Methods: This study included 59 older adults aged ≥60 with and without a history of COVID-19. The cardiopulmonary response parameters including heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse oxygen saturation (O2 sat), rate of perceived exertion (RPE), and leg fatigue were evaluated in the participants after 6MWT and 1-min-STST assessments.Results: Post-COVID-19, older adults showed statistically significant differences in HR, SBP, DBP, O2 sat, RPE, leg fatigue, 6MWT time, and 1-min-STST step numbers at 3, 6, and 12 months (p<0.001). Moreover, older adults showed statistically significant differences in HR, SBP, DBP, RPE, leg fatigue, O2 sat, and 6MWT distance at 3 months post-COVID-19 compared with those in older adults without COVID-19 (p<0.001). Conclusion: While older adults showed recovery of cardiopulmonary response parameters according to 6MWT and 1-min-STST findings at the 12-month follow-up post-COVID-19, these results of these measurements did not return to the values observed in older adults without COVID-19.
Weiwei Decoction alleviates gastric intestinal metaplasia through the olfactomedin 4/nucleotide-binding oligomerization domain 1/caudal-type homeobox gene 2 signaling pathway
Authors: Zhou Di-Shu , Zhang Wei-Jian , Song Shu-Ya , Hong Xin-Xin , Yang Wei-Qin , Li Juan-Juan , Xu Jian-Qu , Kang Jian-Yuan , Cai Tian-Tian , Xu Yi-Fei , Guo Shao-Ju , Pan Hua-Feng , Li Hai-Wen
Published: July 2024

BACKGROUND

Gastric intestinal metaplasia (IM) is a precancerous lesion that is associated with an elevated risk of gastric carcinogenesis. Weiwei Decoction (WWD) is a promising traditional Chinese herbal formula widely employed in clinical for treating IM. Previous studies suggested the potential involvement of the olfactomedin 4 (OLFM4)/nucleotide-binding oligomerization domain 1 (NOD1)/caudal-type homeobox gene 2 (CDX2) signaling pathway in IM regulation.

AIM

To verify the regulation of the OLFM4/NOD1/CDX2 pathway in IM, specifically investigating WWD’s effectiveness on IM through this pathway.

METHODS

Immunohistochemistry for OLFM4, NOD1, and CDX2 was conducted on tissue microarray. GES-1 cells treated with chenodeoxycholic acid were utilized as IM cell models. OLFM4 short hairpin RNA (shRNA), NOD1 shRNA, and OLFM4 pcDNA were transfected to clarify the pathway regulatory relationships. Protein interactions were validated by co-immunoprecipitation. To explore WWD’s pharmacological actions, IM rat models were induced using N-methyl-N’-nitro-N-nitrosoguanidine followed by WWD gavage. Gastric cells were treated with WWD-medicated serum. Cytokines and chemokines content were assessed by enzyme-linked immunosorbent assay and quantitative reverse transcription polymerase chain reaction.

RESULTS

The OLFM4/NOD1/CDX2 axis was a characteristic of IM. OLFM4 exhibited direct binding and subsequent down-regulation of NOD1, thereby sustaining the activation of CDX2 and promoting the progression of IM. WWD improved gastric mucosal histological lesions while suppressing intestinal markers KLF transcription factor 4, villin 1, and MUCIN 2 expression in IM rats. Regarding pharmacological actions, WWD suppressed OLFM4 and restored NOD1 expression, consequently reducing CDX2 at the mRNA and protein levels in IM rats. Parallel regulatory mechanisms were observed at the protein level in IM cells treated with WWD-medicated serum. Furthermore, WWD-medicated serum treatment strengthened OLFM4 and NOD1 interaction. In case of anti-inflammatory, WWD restrained interleukin (IL)-6, interferon-gamma, IL-17, macrophage chemoattractant protein-1, macrophage inflammatory protein 1 alpha content in IM rat serum. WWD-medicated serum inhibited tumor necrosis factor alpha, IL-6, IL-8 transcriptions in IM cells.

CONCLUSION

The OLFM4/NOD1/CDX2 pathway is involved in the regulation of IM. WWD exerts its therapeutic efficacy on IM through the pathway, additionally attenuating the inflammatory response.
Gastric cancer metastatic to the breast: A case report
Authors: Liu Jia-Hui , Dhamija Gaurav , Jiang Yi , He Dan , Zhou Xiao-Cong
Published: July 2024

BACKGROUND

Metastatic breast cancer originating in the gastrointestinal tract is a rare occurrence. The limited number of cases has resulted in incomplete understanding of the disease, making it challenging to differentiate from primary breast cancer. While clinical history and immunohistochemical studies can aid in distinguishing between the two, the management principles and pathogenesis of gastrointestinal metastatic breast cancer remain controversial. The scarcity of data has hampered comprehensive knowledge. Our objective is to shed light on this rare disease through our case study.

CASE SUMMARY

Here, we report a case of breast metastasis from gastric cancer in a 43-year-old woman. This patient was admitted to our hospital with complaints of discomfort in the upper and middle abdomen persisting for two months, as well as black stools for over ten days. She underwent radical distal gastrectomy for gastric cancer, followed by postoperative chemotherapy. Three years later, the patient developed bilateral breast nodules. Imaging studies indicated a high probability of malignancy. She subsequently underwent a right modified radical mastectomy and excision of a left breast mass. Postoperative pathology revealed the right breast tumor was consistent with primary gastric cancer.

CONCLUSION

We present a case of breast metastasis from gastric cancer to contribute to the limited foundation of research into this rare disease.
BRAF K601E-mutated metastatic colorectal cancer in response to combination therapy with encorafenib, binimetinib, and cetuximab: A case report
Authors: Sasaki Makiko , Shimura Takaya , Nishie Hirotada , Kuroyanagi Keita , Kanno Takuya , Fukusada Shigeki , Sugimura Naomi , Mizuno Yusuke , Nukui Takayuki , Uno Konomu , Kojima Yuki , Nishigaki Ruriko , Tanaka Mamoru , Ozeki Keiji , Kubota Eiji , Kataoka Hiromi
Published: July 2024

BACKGROUND

BRAF mutation has been recognized as a negative prognostic marker for metastatic colorectal cancer (mCRC), but these data are from common BRAF V600E-mutated mCRC. Combination therapy of BRAF inhibitor and anti-epidermal growth factor receptor (EGFR) antibody has been approved for BRAF V600E-mutated mCRC. However, BRAF non-V600 mutations are rare mutations, and their clinical behavior is not understood. Moreover, the BRAF K601E mutation is extremely rare in mCRC, and there have been no reports on its specific treatment.

CASE SUMMARY

Herein, we report the case of a 59-year-old female with super aggressive mCRC with multiple metastases, which extended to whole body including mediastinal to abdominal lymph nodes, bones, pleura, and peritoneum. The companion diagnostics of tumor tissues showed RAS/BRAF wild-type without microsatellite instability. She received chemotherapy with mFOLFOX6 (oxaliplatin plus infusional 5-fluorouracil [5-FU] and leucovorin) plus panitumumab, following FOLFIRI (irinotecan plus infusional 5-FU and leucovorin) plus ramucirumab. For the next regimen selection, a comprehensive genomic profiling panel was performed and revealed a BRAF K601E mutation, which was not covered in the initial companion diagnostics. After disease progression, a combination of encorafenib, binimetinib, and cetuximab was selected as third-line chemotherapy. The serum levels of tumor markers were immediately decreased accompanied by improvements in pleural effusion and ascites. However, the disease progressed again, and best supportive care was done instead.

CONCLUSION

This case offers novel insights into the clinical behaviors of BRAF non-V600E-mCRC, potentially advancing personalized therapy for rare and aggressive cases.
Could ESP practitioners have an active role in managing and alleviating students’ communication apprehension?
Authors: Marković Tatjana , Mirković Dragica
Published: July 2024

Communication apprehension (CA) has profound implications for individuals across various settings, impacting emotional, relational, educational, professional, and financial aspects. This study investigates the extent of CA among 115 second-year students, exploring changes in self-perceived CA scores before and after a pedagogic intervention. The research addresses the prevalence of CA among IST and management students, advocating for an expanded role for ESP instructors. It also highlights gender and program-related disparities and identifies specific communication scenarios influencing CA. Utilizing the PRCA-24 instrument, the study assesses self-perceived CA levels in group discussion, meetings, interpersonal communication, and public speaking. The findings demonstrate the effectiveness of the carefully designed course, emphasize the positive influence and importance of incorporating anxiety-reduction techniques into ESP curriculum design and teaching strategies, and point to the active role of ESP instructors in developing students’ communication and soft skills to improve industry readiness.
rove industry readiness.
Interrogating Sustainable Development Goal 1 and poverty in South East Nigeria: Is there any Development to be Sustained?
Authors: Onah Emeka , Ezeodili Walter , Okwueze Felicia
Published: July 2024

This survey examined Sustainable Development Goal (SDG) 1 and its effect on poverty alleviation in the South East of Nigeria. Specifically, the study examined (i) how SDG1 influences income generation in South East Nigeria, (ii) determined the extent to which SDG 1 influenced social protection in South East Nigeria, Two hypotheses guided the study. Analysis of data collected was done using SPSS. The study adopted descriptive research design. The population of the study was 21,955,400. Taro Yamane’s formula was used to determine the sample size of 625. The data was analysed through the use of descriptive and inferential analysis, one sample t-test as used to test the hypotheses. Findings of the study showed that SDG1 had a positive significant influence on income generation, social protection, sustainable livelihood, access to education, and establishment of micro enterprises in South East Nigeria. The study recommended that for SDG1 to further make impact in the South East Nigeria, governments of the five states that make up the zone, should identify the marginalized communities and prioritize the implementation of SDG policies in those communities.
Zjawisko hejtu wśród polskich influencerów i influencerek. Skutki i strategie radzenia sobie ze zjawiskiem
Authors: Zakrzewska Emilia , Tarka Dagmara
Published: July 2024

The phenomenon of hate and hate speech on the Internet is affecting a growing population of people and causing serious social, psychological, as well as economic consequences. Public figures, celebrities, and influencers, that is online professionals, are particularly vulnerable to hate. The final professional group in particular is subjected to continuous evaluation by observers. Given the scale and nature of their activities, which are strongly dependent on the opinion of observers, it can be hypothesised that they experience hate and harassment speech to a greater extent than other social media participants. The perspective of determining the scale of hate among Polish influencers makes it possible to gain knowledge to effectively counteract and prevent negative social and psychological effects. The purpose of the article is to describe the effects and strategies of influencers coping with the phenomenon of online hate. The study of influencers used content analysis of media messages and individual in-depth interviews. The results of the survey showed that the majority (more than 94%) of influencers have experienced hate, which most often concerned their appearance and statements. More than 40% of the surveyed influencers have suffered the effects of hate. The cognitive value is the creation of a catalogue of the effects of hate and hate speech affecting a professional group such as influencers, which will significantly translate into knowledge of methods how to counteract the hate and hate speech experienced by Internet users. The development of a catalogue of consequences and strategies for dealing with hate and hate speech will also make it easier to identify the potential impact of internal and external factors that can amplify the phenomenon of hate on the Internet.
Konstruktywna krytyka, mowa nienawiści czy przemoc słowna? Świadomość zjawiska hejtu w sieci w internetowej społeczności
Authors: Ołtarzewska Karolina , Przybysz Monika
Published: July 2024

Hate speech, verbal violence, hate and trolling are increasingly common issues that almost every user of the Internet and social media have to deal – often as an observer, sometimes as a victim, and sometimes as a hater indeed. In order to understand the increasingly common verbal aggression in online debates in terms of communication, the authors analyzed a fragmentary, targeted social diagnosis regarding the level of awareness of the phenomenon of hate on the Internet and the effects caused by hate speech that directly affect people. The purpose of the research undertaken is to characterize the phenomenon of hate speech in the consciousness of the online community.
Rozwój nowoczesnych technologii w zatrudnieniu a konieczność wprowadzenia odrębnej instytucji prawnej, jaką jest prawo do bycia offline
Authors: Walczak Krzysztof , Chakowski Maciej
Published: July 2024

The subject of the article is the assessment of the legitimacy of introducing a new institution to Polish law, which is the right to be disconnected. According to the authors, this is unnecessary. Based on the analysis of the regulations and the jurisprudence of the Supreme Court, they show that the Labour Code guarantees people who use modern technologies the right to rest. However, the authors agree, that the problem is the practical application of these provisions. Therefore, in their opinion, instead of introducing a new legal institution, it is necessary to increase the legal awareness of workers so that they know what their rights are in this area and, if deemed appropriate, to increase the sanctions for non-compliance.
Especulación mercantil y ética estamental en "El conde Lucanor"
Authors: Miguens Agustina
Published: July 2024

Identificamos, en una serie de ejemplos de El conde Lucanor (CL) de don Juan Manuel, un rechazo a la actividad financiera ligada al mundo mercantil y comercial, propio de la incipiente burguesía. Frente a la posibilidad de ganar fortuna a través de un negocio, Patronio recomienda al conde no fiarse de asuntos inciertos y, en cambio, consolidar el dominio patrimonial sobre la tierra, de este modo reafirmando el modo de producción feudal. No obstante, los cambios de fortuna, la inestabilidad y la conflictividad representada en los relatos son evidencia de un régimen inmerso en la crisis del siglo XIV. En este trabajo rastrearemos los procedimientos textuales en los que se desarrolla la ideología señorial en el CL para sustentar estas posturas y enmarcarlas en un saber tradicional, supuestamente universal.
CAPÍTULO 3: MANEJO DE LOS LÍPIDOS EN LA ENFERMEDAD RENAL CRÓNICA
Authors: Nardelli Natalia , Corral Pablo , Giménez Sergio , Lavalle Cobo Augusto , Nogueira Juan Patricio , Schreier Laura
Published: July 2024

La coexistencia de enfermedad renal crónica (ERC) y diabetes mellitus (DM) actúa en forma sinérgica agravando las consecuencias renales y CV. La evaluación temprana del perfil lipídico permitirá establecer estrategias de tratamiento para disminuir la morbimortalidad por causas CV ateroscleróticas. El patrón lipídico característico de la ERC asociada a DM consiste, principalmente, en hipertrigliceridemia y disminución de los valores de colesterol-HDL (c-HDL). El incremento del nivel de triglicéridos es resultante de mecanismos fisiopatológicos que concurren en ambas patologías: sobreproducción hepática de VLDL, consecuencia de la insulinorresistencia y reducción de la lipólisis de los triglicéridos por disminución de la actividad de la enzima lipoproteína lipasa. La acumulación de los remanentes lipoproteicos constituye un significativo predictor de eventos CV.
CAPÍTULO 9: NEFROTOXICIDAD POR FÁRMACOS
Authors: Papaginovic Marina , Diez Guillermo Rosa , Butto Sonia , González Claudio
Published: July 2024

La nefrotoxicidad inducida por fármacos, también denominada enfermedad renal inducida por fármacos (ERIF), afecta entre el 14% y el 26% de los pacientes adultos y a el 16% de los pacientes pediátricos. Sin embargo, la incidencia de ERIF puede llegar al 66%. Entre los adultos mayores la incidencia es mayor, puesto que estos se caracterizan por presentar múltiples enfermedades, la polifarmacia y, por lo tanto, están sujetos a procedimientos diagnósticos y terapéuticos que pueden dañar los riñones. La disfunción renal suele ser reversible al suspender el fármaco causante; sin embargo, puede producir daño estructural irreversible. La nefrotoxicidad se manifiesta en un amplio espectro, reflejando daño en diferentes segmentos de la nefrona, incluidos los segmentos glomerulares y tubulares.
Ransomware Mitigation Strategies for Endpoints: Fortifying Cyber Defense through Proactive Security Measures
Authors: Mandru Srikanth ,   USA
Published: July 2024

Ransomware is a major cyber threat that causes significant financial loss and operational damage to organizations. This paper outlines proactive strategies for enhancing endpoint security against ransomware. It continues to describe likely practical mitigation approaches after an in-depth analysis and extends its focus to potential use cases. The problem statement is analyzed, and solution examples are proposed, along with the prediction of future conditions, to help organizations make sound decisions in addressing advanced threats to elevate endpoint security and alleviate the risks of ransomware. Built on the two authoritative views, the paper will give actionable recommendations on strengthening cyber defenses and protecting businesses from ransomware. The all-encompassing approach will certainly better position organizations of all sizes to take proactive measures to protect their assets from the all-pervasive ransomware threat.
УЧАСТИЕ МОЛОДЁЖНЫХ ОРГАНИЗАЦИИ В СИСТЕМЕ ОБРАЗОВАНИЯ: ИСТОРИЧЕСКИЙ АНАЛИЗ НА ПРИМЕРЕ ЗАРАФШАНСКОГО ОАЗИСА
Authors: Норов Шухрат
Published: July 2024

В исследования дано историческое значение деятельности молодёжных организаций в сфере образования на территории Зарафшанского оазиса. Рассмотрена краткая характеристика принятых законодательных основ в системе образования Узбекистана. В результатах дискуссии данного исследования, отмечены существующие проблемы образования в отдалённых сельских районах Зарафшанского оазиса.
ВОПРОСЫ ТИПОЛОГИИ И ЛЕКСИКОГРАФИЧЕСКОЕ ИССЛЕДОВАНИЕ БЫТОВОЙ ЛЕКСИКИ (НА МАТЕРИАЛЕ РУССКОГО И УЗБЕКСКОГО ЯЗЫКОВ)
Authors: Нарзуллаева Мафтуна , Юсупова Шохсанам , Иссатуллаева Феруза
Published: July 2024

Данная статья посвящена типологии и лексикографическому исследованию повседневной лексики на основе материалов русского и узбекского языков. В исследовании рассматриваются особенности формирования, использования и зафиксированности повседневной лексики в словарях обоих языков. Анализируются типологические различия и сходства в лексических системах русского и узбекского языков, а также методы и подходы к лексикографической фиксации повседневной лексики.
BO‘LAJAK PEDAGOGLARDA KASBIY DEFORMARSIYANI RIVOJLANTIRISHNING PEDAGOGIK PSIXOLOGIK USULLARI
Authors: To’lanova Mahliyo
Published: July 2024

Ushbu maqolada  oliy ta’lim muassasalarida kasbiy rivojlanishni takomillashtirish va ta'lim sohasidagi munosabatlar va  ishtirokchilar o'rtasidagi deformatsiya (mehnatga moslashish, ko’nikish) amaliyotning ilmiy va amaliy tadqiqotlariga bag'ishlangan. Talabalarda kasbiy deformatsiya yondashuvning o‘rni va ahamiyati haqida so‘z yuritiladi. Mamlakatimizni iqtisodiy, siyosiy va ma’naviy jixatdan  ertangi kuni hisoblangan bo‘lajak pedagoglarni o‘z kasbini mohir ustasi bo‘lib yetishishi uchun tavsiyalar berilgan.
РОЛЬ ГУМАННО-ЛИЧНОСТНОЙ ПЕДАГОГИКИ Ш.А.АМОНАШВИЛИ В РАЗВИТИИ ЛИЧНОСТИ УЧАЩЕГОСЯ
Authors: Давыдова Руфина
Published: July 2024

Данная статья посвящена анализу гуманно-личностного подхода Ш.А.Амонашвили, который является эффективным инструментом в развитии индивидуальных и внутренних качеств учеников. Приводятся результаты опросного исследования по данному вопросу, а также рассматриваются основные идеи педагогов-гуманистов. Статья предназначена для специалистов в области педагогики, психологии и всех тех, кто ведет исследования в области образования.
Enhancing Ration Provision: Biometric Integrated Transparent Smart Ration Distribution System
Authors: Milan Kumar Motta  , Devarabhotla Pratyusha  , Saathvika Revalla  , Sailaja Nemani  , Renuka Avula  , P.Sri venkat
Published: July 2024

A parliamentary act of India come to force in 2013 designed to supply financed food grains to nearly 100 crores peoples of country, the right to food act, the PDS has emerged as a revolutionary method designed to enhance the delivery of financed food grains to eligible families. This study aims to refine the ration provision system by incorporating biometric technologies and improving transparency. The research introduces an entirely automated platform named Smart Ration Distribution System (SRDS) which maintains a database of user profiles to monitor their monthly and annual consumption of various financed food grains. SRDS offers several benefits including reducing customer wait times, ensuring reliable authentication and identification of eligible individuals real-time tracking and monitoring of the distribution process enabling timely interventions and resource allocation based on demand patterns and reducing administrative burdens. Additionally, such a system could be effectively utilized for implementing other social welfare programs such as the Telangana Aasara Pension Scheme, Aarogyasri Ammavadi and Anganwadi. This project aims to develop a user-friendly highly secure biometric ration distribution system constructed using an Arduino controller under the supervision of a ration distributor.
Dilemmas and Malgovernability in the Politics of Managing the Kulukubuk Waterfall Tourism Market in Siberut, Mentawai Islands Regency
Authors: Ahmad Munawar , Samaloisa Rijel
Published: July 2024

This paper will explain some dilemmas and malgovernability on tourism governing in Kulukubuk tourism’s destination. Kulukubuk is the name of water fall located in Madobag’s forest, Siberut island, Mentawai district. Before state governance taking handled, Kulu kubuk have been a famous destination for tourism. Kulukubuk has exotic waterfall for relaxing and healing surrounded by rain forest tree. For Mentawai people, Kulukubuk has strong myth related their circle of life, they believe the water of Kulukubuk bring their body and also their properities will be blessed by Taika. In that time, Kulukubuk totally governing by local people and give back benefit to them. But, since 2019, state government totally govern Kulukubuk, and Tourism department of Mentawai was refining all facilitate for access to Kulu kubuk with better construction. After constructed, state government do not bring local people involve for governing. Until four years passed, Kulukubuk’s facilities was abandon, damaged and useless. It was portraying a malgovernability within, it is our reason why this paper written.
Rejection of Application for Registration of Trademark Payfazz Agen Keuangan Nusantara Based on Law Number 20 Year 2016: Penolakan Permohonan Pendaftaran Merek Dagang Payfazz Agen Keuangan Nusantara Berdasarkan Undang-Undang Nomor 20 Tahun 2016
Authors: Agriansyah Herdi
Published: July 2024

The principle of trademark registration in Indonesia is first to file, i.e. who first registers his trademark is considered as the owner or holder of rights to the trademark. Trademark registration should not be based on bad faith, because in Law Number 20 of 2016 concerning Trademarks and Geographical Indications, the application for trademark registration must be rejected. The purpose of this study is to determine the refusal of the application for registration of the Payfazz Agen Keuangan Nusantara trademark based on Law Number 20 of 2016 concerning Trademarks and Geographical Indications in Decision Number 25/Pdt.Sus-Merek/2020/Pn.Niaga.Jkt.Pst and to determine the legal consequences of the refusal of the application for registration of the Payfazz Agen Keuangan Nusantara trademark based on Law Number 20 of 2016 concerning Trademarks and Geographical Indications in Decision Number 25/Pdt.Sus-Merek/2020/Pn.Niaga.Jkt.Pst. This research uses a normative juridical approach method with analytical descriptive research specifications. The data collection method is done by literature study, the data obtained is presented with narrative text, and the data analysis method used is qualitative normative method.  The results of the research can be concluded that the refusal of the application for registration of the mark “PAYFAZZ AGENT FINANCIAL OBLIGATIONS NUSANTARA‘’ which was rejected by the Defendant was appropriate in accordance with the provisions of Article 21 paragraph (1) letter b of Law Number 20 of 2016 concerning Trademarks and Geographical Indications and the legal consequences of the refusal of registration of the mark ‘PAYFAZZ AGENT FINANCIAL OBLIGATIONS NUSANTARA’' is that the Plaintiff has lost the right, interests, and benefits under the law arising from the Trademark ''PAYFAZZ OBLIGATORY FINANCIAL AGENT NUSANTARA'', and has suffered immaterial losses because the problems with the registration of the Trademark ''PAYFAZZ OBLIGATORY FINANCIAL AGENT NUSANTARA'' took up a lot of time, costs, energy, and thoughts of the Plaintiff, because the Defendant erred in applying the applicable law.
Pemboikotan Produk Pendukung Israel Berdasarkan Fatwa MUI Nomor 83 Tahun 2023 Ditinjau dari Maslahah
Authors: Nahwi Padang Amirul , Hasanah Uswatun
Published: July 2024

This research aims to examine the boycott of products affiliated with Israel based on MUI Fatwa No. 83 of 2023 concerning the Law on Support for the Palestinian Struggle viewed from the issue of murlahah. This type of research is normative research with a conceptual approach. This research is descriptive in nature, then data is collected through document study, and data is processed using qualitative methods. The results of this research show that the boycott of Israeli products in MUI Fatwa No. 83 of 2023 in Maslahah Murlah's view is valid, this is because the boycott of Israeli products occupies the position of Maslahah Darury. By not buying Israeli products, we indirectly mean we are helping our brothers and sisters in Palestine.
Peran Mediasi dalam Menyelesaikan Sengketa Tanah Sebagai Alternatif Penyelesaian Sengketa di Luar Pengadilan: Studi Kasus di Desa Sumberjaya Kecamatan Tempuran Kabupaten Karawang
Authors: Bintang S Andi Muhamad , Amaliya Lia , Ixal Da’i Safuad , Ardiansyah Muhamad Aldy , Yusuf Suroso Zulfiansyah
Published: July 2024

Agrarian law legally regulates land, with Law Number 5 of 1960 concerning Basic Agrarian Regulations as its juridical basis. Land disputes are one of the land issues that often occur in Indonesia, with complicated and unique problem characteristics, which are different from problems in other fields. An example of a land dispute occurred in Sumberjaya Village. Settlement of land disputes can be done through various means, both through the courts and outside the courts, such as Negotiation, Arbitration, Conciliation, and Mediation. The focus of this article is to gain an understanding of how mediation plays a role in land dispute resolution as an alternative dispute resolution that does not involve the court and how land disputes are resolved in Sumberjaya Village through mediation. This article uses empirical juridical research methods. The results show that mediation plays an important role in the process of resolving land disputes, although there are weaknesses in its application. In an effort to resolve land disputes in Sumberjaya Village, the disputing parties have attempted to settle through mediation dozens of times, but there are obstacles and constraints in the form of difficulties in harmonizing the interests of the parties involved in the conflict, as well as difficulties in ensuring their presence in the mediation process, which causes until now the land dispute in Sumberjaya Village has not yet had a meeting point in its resolution.
Psikologi Keluarga Sebagai Pedoman dalam Pola Pengasuhan Anak Remaja
Authors: Matondang Fatiha Sabila Putri , Marpaung Mukhlis Tri Mulya , Alfath Lubis Muhammad , Syafitri Lubis Juli Aini , Aulia Rahma
Published: July 2024

The personality of a child is heavily influenced by genetic and environmental factors, the urgency of the role of the parent in the formation of the child's personality is of paramount importance, since the parent is the first to make a contribution to a child' s personality. Parental patterns are crucial to children's development. In addition, adolescence is a transition from childhood to adulthood, where changes occur, including physical, social, and mental changes. With all these changes, adolescents face the challenge of controlling their emotions and behaving according to social norms. Parental patterns also play a role in the process of changes that adolescents experience, as well as how they behave and behave in society. The aim of this study was to find out how parental patterns relate to the development of children in adolescence.
Manajemen Program Pengajian Muhammadiyah dalam Peningkatan Mutu Guru Pendidikan Agama Islam di SMP Muhammadiyah 7 Medan Tahun 2024
Authors: Siti Khairiah  , Ali Imran Sinaga
Published: July 2024

Recitation is a means of knowledge that can increase motivation, shape character and obey Allah. This recitation has a positive impact and has an important role in creating thought patterns, attitudes and behavior that are in accordance with Islamic teachings. Apart from that, teachers and the community involved in it can feel the benefits of this activity as a means of moral development and increasing Islamic knowledge to improve the quality of the listeners. This research uses a descriptive qualitative method with data collection techniques in the form of observation, interviews and documentation of teachers. This research aims to improve the quality of teachers at Muhammadiyah Middle School 7 Medan, to find out how the recitation process takes place and what factors support and inhibit the recitation process.
Strategi Pengembangan Sumber Daya Laut dalam Meningkatkan Ekonomi Masyarakat Desa Karampi Kecamatan Langgudu Kabupaten Bima
Authors: Iin yuliani  , Ihwan P Syamsuddin
Published: July 2024

This research aims to reveal the strategy for developing marine resources carried out by Karampi village and whether developing marine resources can improve the community's economy. This research uses a descriptive qualitative approach. Data collection methods were carried out using interviews, observation and documentation. Data analysis was carried out through several stages, namely data reduction, data presentation, and drawing conclusions. The results of the research show that the strategy carried out by the Karampi village to develop marine products is first, by creating an entrepreneurial group in each hamlet which is formed directly by the village to process marine products such as fish which are processed into fish balls, fish nuggets, fish floss, and fish crackers. Apart from fish, there is seaweed which is processed into seaweed dodol, seaweed pudding, seaweed jelly and seaweed cendol ice. The seafood that is processed into food and drinks is marketed through collaboration with kiosks and markets in Karampi village. Second, the village provides infrastructure in the form of bot machines for fishermen who have charts. The development of marine resources carried out by the village is very supportive of improving the community's economy and can provide employment opportunities for the community. The research results contribute to the formulation of blue economy policies. The limitation of this research is that the data used is still limited to secondary data types, namely previous articles.
Analisis Perhitungan Biaya Pesanan dalam Menentukan Harga Pokok Produksi Job Order Costing Kue Karawo
Authors: Monoarfa Valentina , Feronika Juningsih , Emilia Sari Indi
Published: July 2024

This study aims to analyze the calculation of order costs in determining the cost of production for Karawo Cakes using the job order costing method. This method allows the company to determine production costs more accurately by allocating direct and indirect costs to each specific order. In this research, data were collected through interviews and direct observation of the production process of Karawo Cakes at one of the SMEs in Gorontalo, namely Toko Karwo Li Maya. The results of the analysis indicate that the use of the job order costing method can provide more detailed and accurate information regarding the components of production costs, including raw materials, direct labor, and factory overhead. This information is crucial in determining competitive selling prices and improving production efficiency. Thus, the job order costing method helps the company improve the accuracy of production cost calculations and supports better decision-making in pricing strategies.
Analisis Hasil Perhitungan Harga Pokok Produksi Metode Full Costing Vs Variabel Costing pada UMKM BMS Kota Gorontalo
Authors: Monoarfa Valentina , Lepa Yuliana , Datau Dinarova Salsavia
Published: July 2024

Calculating the cost of production is very important for manufacturing companies considering that one of the benefits of the cost of production is determining the selling price of the product. There are two methods for determining the cost of production, namely the full costing method and the variable costing method. This research aims to determine the calculation of the cost of production of BMS MSMEs using the full costing and variable costing methods. The method in this research is the Quantitative Descriptive method. The data collection technique for this research is by observation/interview. The problem in this research is to compare the calculation of product cost with full costing and variable costing methods. The purpose of this research is to determine the determination of the cost of production based on the method used by the company, namely the full costing and variable costing methods. The results of the research obtained the cost of production using the full costing method of Tapi. 667.77, while with the variable costing method it is Rp. 334.44. The conclusion from this research is that there are differences in determining the cost of products using these two methods.
Perhitungan Harga Pokok Produk Bersama dan Produk Sampingan dengan Penetapan Harga Jual Produksi Tahu dan Ampasnya
Authors: Monoarfa Valentina , Pade Nurwinda , Monika Aswad Aulia
Published: July 2024

The research project for estimating the cost of goods together and by-products of Ms. Sri's tofu business is discussed in this article. Main products are goods that meet predetermined criteria and are the company's main goal, while side products are goods that are created unavoidably but are not the company's main goal. The aim of this research is to calculate the cost of production of tofu and dregs, and determine the appropriate selling price for these two products. Case studies and literature reviews were the research approaches used in this project. Case studies involve talking to companies and doing research, while literature studies involve looking through books and other sources of information for relevant information. The research method used is the joint cost method with a full costing method approach.
Pengendalian Biaya Kedelai Home Industry Tahu-Tempe Mbak Sri
Authors: Monoarfa Valentina , Ahmad Nur Khairunnisa , Mooduto Pindrawaty
Published: July 2024

This study aims to analyze the material cost control in Mbak Sri's home industry of tofu and tempeh production. Material costs constitute a significant portion of the total production costs, and effective control measures are crucial for ensuring profitability. The research employs a qualitative approach, utilizing observation and in-depth interviews to gather data. The findings reveal that Mbak Sri implements several cost control strategies, including careful material selection, efficient utilization, and waste minimization. However, challenges arise due to fluctuating raw material prices and limited bargaining power. The study recommends implementing a comprehensive material management system, establishing strategic supplier relationships, and exploring alternative sourcing options to enhance cost control measures. By addressing these recommendations, Mbak Sri's home industry can improve its overall operational efficiency and profitability.
Implementation of Word Search Games in Arabic Vocabulary Learning for Taufiqurrahman Integrated Islamic Elementary School Students
Authors: Fahira Azzahir Syifa , Rachmawati Miatin
Published: July 2024

Learning Arabic in Integrated Islamic Elementary Schools holds significant importance in the context of religious education and character development of children. Although Arabic is a mandatory language for Muslims, students often face challenges in learning it. The role of schools, especially for Integrated Islamic Elementary School, in overcoming these challenges is crucial by building better learning effectiveness through a comprehensive, interactive, and enjoyable approach for students to increase their interest in learning Arabic. The use of technology such as educational apps or games can also be an effective means to strengthen students' language skills. Through this approach, it is expected that students can overcome difficulties in learning Arabic and gain a better understanding of Islam.
CONTRIBUTION OF VLADIMIR PETROVICH LAVROV TO THE DEVELOPMENT OF THE TOPIC OF COUNTERING THE INVESTIGATION OF CRIMES
Authors: Kaygorodova Olga S.
Published: July 2024

The development of all modern achievements reflects, among other things, the level of existing crime. Methods of committing crimes are becoming more technologically advanced, and the professionalism of those committing crimes is growing. And their reluctance to bear deserved criminal liability for illegal acts gives rise to ever new ways of countering the investigation of crimes. Undoubtedly, significant in the development of the study of the topic of countering the investigation of crimes are the works of Vladimir Petrovich Lavrov, Honored Scientist of the Russian Federation, Doctor of Law, Professor, as well as his students, who enriched the theoretical basis of the topic under study, which made it possible to create recommendations for law enforcement agencies on its basis
RAIDER SEIZURE AS AN UNLAWFUL ACT IN THE RUSSIAN FEDERATION
Authors: Kochedykova Victoria M. , Mayorova Svetlana Ye.
Published: July 2024

Over the past two decades, raiding has become a serious threat to the economic security of modern business, the economy of the country as a whole and national security. The paper examines such an illegal act as raiding. The definition of raiding is given, the author’s definition is offered. The statistics of recent years of the number of raider crimes in the dynamics of change is considered. The current legislation, responsibility provided for the commission of this crime is studied. Criminal-legal and criminological aspects of counteraction to raiding are studied from the point of view of creation of a separate article of the Criminal Code of the Russian Federation for this act. In view of the absence in the current Criminal Code of the Russian Federation of an article providing for differentiated sanctions for raider seizure, there are problems in the qualification, investigation of this crime, and subsequently, bringing to criminal responsibility of guilty persons. The question of the necessity of introducing a separate article in the Criminal Code of the Russian Federation providing for punishment for raider seizure is studied, different approaches of researchers and scientists on this issue are given. The ways of improving the legislative and legal system in the field of counteraction to this illegal act are considered. The wording of a separate article of the Criminal Code of the Russian Federation for raider seizure is proposed.
تحليل الأخطأ الصوتية في نطق مفردات اللغة العربية لدى الطلبة في مدرسة الإبراهيمي المتوسطة غرسيك
Authors: Farisyatul Fitriah  , Muh Sabilar Rosyad  , Afthon Ulin Nuha
Published: July 2024

Phonological errors in Arabic pronunciation are normal in the language learning process, especially when someone is learning a new language or when a child is developing their speaking skills. Therefore, this simple research seeks to highlight forms of phonetic errors in Arabic vocabulary, in addition to identifying problems faced by middle school students in pronouncing Arabic vocabulary. Researchers use the case study method which comes from a qualitative research approach. The main data sources are students and Arabic language teachers, while secondary data are books and scientific journals related to the research subject. Data were collected through three methods, namely observation, interviews, and documentation, which were then analyzed descriptively interactively. All data is checked for validity through the source triangulation method and the accuracy of observations. The results of this research are: 1) The most prominent form of phonological error experienced by students is substitution, namely the pronunciation of words that are close and similar in their output in such a way that it is difficult for them to identify the differences between them. Likewise with missing, namely the pronunciation of Arabic vocabulary which has a long origin in its pronunciation, where students pronounce it in short form or vice versa. 2) The problems faced by students in connection with phonological errors are divided into two, namely linguistic and non-linguistic problems.
إدارة تنفيذ برنامج تنمية المواهب اللغوية لترقية مهارة الكلام باتحاد طلبة اللغة العربية بجامعة عبد الحليم
Authors: Hafizh Abdul Hafizh Nur Fuadi , Mualana Yusuf Qordhowi  , Zakiyah Arifah
Published: July 2024

The language talent development program was introduced on the basis of the lack of interest and love among students regarding the skill of speaking, so the focus of this research lies in the administrative implementation function in the form of implementing the language talent development program implemented by the administration of the Language Talent Development Division of the Arabic Language Teaching Students Association at Kiahi Al-Haj University. Abd alhalim. The aim of this research is: First, we want to know the management of the implementation of language talent development programmes. Secondly, I want to know the problems in the language talent development programme. This research uses field research methods of a qualitative, descriptive nature, where the researcher explains the process of the language talent development program from implementation of activities to evaluation. The primary data source for this research is members of the Language Talent Development department directors who understand the field and are supported by the findings of accountability reports. The results of this research showed that the implementation of the language talent development program, which consists of six areas of activity, takes place inside and outside the classroom, which consists of three stages, which are the introduction, basic activities, and conclusion. The only problem facing the language talent development program is the lack of trainers, language facilities, and supporting staff to make the language talent development program successful. Core and closing activities.