bluuebunny/crossref_metadata_2025 huggingface dataset:
Prenatal Exome Sequencing Analysis in Fetuses with Various Ultrasound Findings
Authors: Borrell Antoni , Ordoñez Elena , Pauta Montse , Otaño Juan , Paz-y-Miño Fernanda , de Almeida Mafalda , León Miriam , Cirigliano Vincenzo
Published: December 2023

Objectives: To evaluate the use of Exome Sequencing (ES) for the detection of genome-wide Copy Number Variants (CNVs) and the frequency of SNVs-InDels in selected genes related to developmental disorders in a cohort of consecutive pregnancies undergoing invasive diagnostic procedures for minor or simple ultrasound findings with no indication of ES. Methods: Women undergoing invasive diagnostic testing (chorionic villus sampling or amniocentesis) for QF-PCR and chromosomal microarray analysis (CMA) due to prenatal ultrasound findings without an indication for ES were selected over a five-month period (May–September 2021). ES was performed to compare the efficiency of genome-wide CNV detection against CMA analysis and to detect monogenic disorders. Virtual gene panels were selected to target genes related to ultrasound findings and bioinformatic analysis was performed, prioritizing variants based on the corresponding HPO terms. The broad Fetal Gene panel for developmental disorders developed by the PAGE group was also included in the analysis. Results: A total of 59 out of 61 women consented to participate in this study. There were 36 isolated major fetal anomalies, 11 aneuploidy markers, 6 minor fetal anomalies, 4 multiple anomalies, and 2 other ultrasound signs. Following QF-PCR analysis, two uncultured samples were excluded from this study, and six (10%) common chromosome aneuploidies were detected. In the remaining 51 cases, no pathogenic CNVs were detected at CMA, nor were any pathogenic variants observed in gene panels only targeting the ultrasound indications. Two (3.9%) monogenic diseases, apparently unrelated to the fetal phenotype, were detected: blepharo-cheilo-odontic syndrome (spina bifida) and Duchenne muscular dystrophy (pyelocaliceal dilation). Conclusions: In our series of pregnancies with ultrasound findings, common aneuploidies were the only chromosomal abnormalities present, which were detected in 10% of cases. ES CNV analysis was concordant with CMA results in all cases. No additional findings were provided by only targeting selected genes based on ultrasound findings. Broadening the analysis to a larger number of genes involved in fetal developmental disorders revealed monogenic diseases in 3.9% of cases, which, although apparently not directly related to the indications, were clinically relevant.
Electrochemical Skin Conductance by Sudoscan in Non-Dialysis Chronic Kidney Disease Patients
Authors: Chiu Liang-Te , Lin Yu-Li , Wang Chih-Hsien , Hwu Chii-Min , Liou Hung-Hsiang , Hsu Bang-Gee
Published: December 2023

Background. Peripheral neuropathy is prevalent among patients with chronic kidney disease (CKD). Sudoscan non-invasively detects polyneuropathy by measuring electrochemical skin conductance (ESC). We conducted a study on sudomotor function in CKD patients across various stages based on their estimated glomerular filtration rate (eGFR). Methods. In this cross-sectional study of 700 CKD patients, all underwent Sudoscan. Pathological ESC was defined as hands < 40 μS or feet < 50 μS. Clinical neuropathy scores including Michigan Neuropathy Screening Instrument (MNSI) and Douleur Neuropathique en 4 questionnaire (DN4) were obtained. Results. Among participants, 344 had diabetes and 356 did not. Hands and feet ESC decreased with CKD progression (median (IQR) in stage 1–2, 3, 4–5: 54.0 (39.0–68.0), 45.5 (30.0–63.0), 41.8 (26.5–60.5), p trend < 0.001; 64.5 (53.5–74.0), 60.5 (43.0–72.5), 55.0 (39.0–69.8), p trend < 0.001). Pathological hands and feet ESC increased in later CKD stages (stage 1–2, 3, 4–5: 26.6%, 40.9%, 45.7%, p trend < 0.001; 21.7%, 34.0%, 40.6%, p trend < 0.001). Positive hands and feet ESC-eGFR correlation existed irrespective of diabetes. Diabetic patients had lower hands and feet ESC than non-diabetics as CKD progressed. However, multivariate regression found no significant ESC-eGFR association. Sudoscan correlated with clinical neuropathy scores. Conclusion. Pathological sudomotor function was common in non-dialysis CKD stages 4–5. Diabetic patients had worse function. Sudomotor dysfunction progressed with renal disease but eGFR was not an independent risk factor.
A Robust Machine Learning Model for Diabetic Retinopathy Classification
Authors: Tăbăcaru Gigi , Moldovanu Simona , Răducan Elena , Barbu Marian
Published: December 2023

Ensemble learning is a process that belongs to the artificial intelligence (AI) field. It helps to choose a robust machine learning (ML) model, usually used for data classification. AI has a large connection with image processing and feature classification, and it can also be successfully applied to analyzing fundus eye images. Diabetic retinopathy (DR) is a disease that can cause vision loss and blindness, which, from an imaging point of view, can be shown when screening the eyes. Image processing tools can analyze and extract the features from fundus eye images, and these corroborate with ML classifiers that can perform their classification among different disease classes. The outcomes integrated into automated diagnostic systems can be a real success for physicians and patients. In this study, in the form image processing area, the manipulation of the contrast with the gamma correction parameter was applied because DR affects the blood vessels, and the structure of the eyes becomes disorderly. Therefore, the analysis of the texture with two types of entropies was necessary. Shannon and fuzzy entropies and contrast manipulation led to ten original features used in the classification process. The machine learning library PyCaret performs complex tasks, and the empirical process shows that of the fifteen classifiers, the gradient boosting classifier (GBC) provides the best results. Indeed, the proposed model can classify the DR degrees as normal or severe, achieving an accuracy of 0.929, an F1 score of 0.902, and an area under the curve (AUC) of 0.941. The validation of the selected model with a bootstrap statistical technique was performed. The novelty of the study consists of the extraction of features from preprocessed fundus eye images, their classification, and the manipulation of the contrast in a controlled way.
Applicability Evaluation of the Global Synthetic Tropical Cyclone Hazard Dataset in Coastal China
Authors: Li Xiaomin , Hou Qi , Zhang Jie , Zhang Suming , Du Xuexue , Zhao Tangqi
Published: December 2023

A tropical cyclone dataset is an important data source for tropical cyclone disaster research, and the evaluation of its applicability is a necessary prerequisite. The Global Synthetic Tropical Cyclone Hazard (GSTCH) dataset is a dataset of global tropical cyclone activity for 10,000 years from 2018, and has become accepted as a major data source for the study of global tropical cyclone hazards. On the basis of the authoritative Tropical Cyclone Best Track (TCBT) dataset proposed by the China Meteorological Administration, this study evaluated the applicability of the GSTCH dataset in relation to two regions: the Northwest Pacific and China’s coastal provinces. For the Northwest Pacific, the results show no significant differences in the means and standard deviations of landfall wind speed, landfall pressure, and annual occurrence number between the two datasets at the 95% confidence level. They also show the cumulative distributions of central minimum pressure and central maximum wind speed along the track passed the Kolmogorov–Smirnov (K-S) test at the 95% confidence level, thereby verifying that the GSTCH dataset is consistent with the TCBT dataset at sea-area scale. For China’s coastal provinces, the results show that the means or standard deviations of tropical cyclone characteristics between the two datasets were not significantly different in provinces other than Guangdong and Hainan, and further analysis revealed that the cumulative distributions of the tropical cyclone characteristics in Guangdong and Hainan provinces passed the K-S test at the 95% confidence level, thereby verifying that the GSTCH dataset is consistent with the TCBT dataset at province scale. The applicability evaluation revealed that no significant differences exist between most of the tropical cyclone characteristics in the TCBT and GSTCH datasets, and that the GSTCH dataset is an available and reliable data source for tropical cyclone hazard studies in China’s coastal areas.
Assessment of Selected Alternative Fuels for Spanish Navy Ships According to Multi-Criteria Decision Analysis
Authors: Maceiras Rocio , Alfonsin Victor , Alvarez-Feijoo Miguel A. , Llopis Lara
Published: December 2023

Climate change and environmental degradation are growing concerns in today’s society, which has led to greater awareness and responsibility regarding the need to adopt sustainable practices. The European Union has established the goal of achieving climate neutrality by 2050, which implies a significant reduction in greenhouse gas emissions in all sectors. To achieve this goal, renewable energies, the circular economy, and energy efficiency are being promoted. A major source of emissions is the use of fossil fuels in different types of ships (from transport ships to those used by national navies). Among these, it highlights the growing interest of the defense sector in trying to reduce these emissions. The Spanish Ministry of Defense is also involved in this effort and is taking steps to reduce the carbon footprint in military operations and improve sustainability in equipment acquisition and maintenance. The objective of this study is to identify the most promising alternative fuel among those under development for possible implementation on Spanish Navy ships in order to reduce greenhouse gas emissions and improve its capabilities. To achieve this, a multi-criteria decision-making method will be used to determine the most viable fuel option. The data provided by the officers of the Spanish Navy is of great importance, thanks to their long careers in front of the ships. The analysis revealed that hydrogen was the most suitable fuel with the highest priority, ahead of LNG, and scored the highest in most of the sections of the officials’ ratings. These fuels are less polluting and would allow a significant reduction in emissions during the navigation of ships. However, a further study would also have to be carried out on the costs of adapting to their use and the safety of their use.
Mid-Infrared Spectroscopic Study of Cultivating Medicinal Fungi Ganoderma: Composition, Development, and Strain Variability of Basidiocarps
Authors: Synytsya Andriy , Bleha Roman , Skrynnikova Anastasia , Babayeva Tamilla , Čopíková Jana , Kvasnička František , Jablonsky Ivan , Klouček Pavel
Published: December 2023

Attenuated total reflection Fourier-transform infrared (ATR-FTIR) spectroscopy was proposed for rapid, versatile, and non-invasive screening of Ganoderma basidiocarps to assess their potential for specific applications. Fifteen species and strains of this fungus were selected for analysis, and fine sections at different parts of young and mature basidiocarps were obtained. The spectra of fungal samples showed significant differences interpreted in terms of biochemical composition using characteristic bands of proteins, polysaccharides, lipids, and triterpenoids. Obviously, for the transverse sections in trama, especially in the basal part, the most intense bands at 950–1200 cm−1 corresponded to polysaccharide vibrations, while for the superficial sections, the bands of carbonyl and aliphatic groups of triterpenoids at 1310–1470, 1550–1740, and 2850–2980 cm−1 predominated. The pilei, especially hymenium tubes, apparently contained more proteins than the bases and stipes, as evidenced by the intense bands of amide vibrations at 1648 and 1545–1550 cm−1. The specificity of the Ganoderma basidiocarp is a densely pigmented surface layer rich in triterpenoids, as proved by ATR-FTIR spectroscopy. The spectral differences corresponding to the specificity of the triterpenoid composition may indicate the prospects of individual strains and species of this genus for cultivation and further use in food, cosmetics, or medicine.
The Effect of Perceived Real-Scene Environment of a River in a High-Density Urban Area on Emotions
Authors: Li Mengyixin , Liu Rui , Li Xin , Zhang Shiyang , Wu Danzi
Published: December 2023

Public sub-health has emerged as a pressing concern in densely populated urban areas. The urban environment, with its innate ability to modulate public emotions, harbors a precious resource in the form of urban rivers, which provide a serene and verdant space. This study focuses on the Liangma River in Chaoyang District, Beijing, selecting two rivers with diverse landscape features as the subjects of research. By employing physiological feedback data in conjunction with a subjective questionnaire, the emotional impact of high-density urban riverside spaces on individuals is quantitatively analyzed. Electrocardiogram (ECG) data, eye movement data, and the positive–negative emotion scale (PANAS) are subjected to data analysis. The study reveals the following key findings: (1) The riverside landscape in high-density urban areas exerts a positive influence on emotional well-being. Individuals in more natural river settings experience greater levels of contentment and relaxation, while those in areas with a higher proportion of artificial elements exhibit increased excitement and happiness. Moreover, scenes characterized by a greater degree of greening have a more pronounced soothing effect on mood. (2) A specific correlation between visual characteristics and emotional fluctuations is observed. The waterfront side of the trail exerts a stronger spatial attraction, and a higher proportion of blue and green spaces significantly contributes to stress relief. (3) The utilization of human-induced engineering technology, which captures emotional changes through physiological feedback, demonstrates a higher level of accuracy and is well-suited for small-scale studies. These findings highlight the potential of arranging diverse types of waterfront footpath landscapes in high-density urban areas and approaching waterfront landscape design and transformation from a novel perspective centered on health intervention. Such efforts hold promise for alleviating the daily pressures faced by the general public and fostering the development of a “healthy city”.
Levels of Variation in Subordinates of Immediate Succession in Current Spanish
Authors: Suñer Gratacós Avel·lina
Published: December 2023

In this paper, I analyze, from a compositional perspective, the relevant features to construct the interpretation of immediate succession between a subordinate event and the event that takes place in the main sentence. Among all the components involved in the construction of the meaning of immediate succession, I focus particularly on the subordinators, which present a mosaic of variation in current Spanish. The key ideas that can be derived from the data analysis are the following. First: subordinators of immediate succession are the loci of variation of temporal subordinates. Second: a subordinator of immediate succession is a “linguistic variable” that can be syntactically materialized in different forms by applying general rules that do not change the meaning, although sometimes they do change the grammatical category. Third: in the diachronic evolution of Spanish, several patterns of internal structure have emerged for immediate succession subordinators. However, most of them have ceased to be productive, although some subordinators that were coined with these patterns have survived as fossils in the current language. Fourth: the only productive pattern in the present language can be reduced to the Adv (immediacy) + que scheme, which goes back to Late Latin.
Biological Activities of Molecules Derived from Olea europaea L. Tested In Vitro
Authors: Marrone Giulia , Urciuoli Silvia , Candi Eleonora , Bernini Roberta , Vanni Gianluca , Masci Claudia , Guerriero Cristina , Mancini Mara , De Lorenzo Antonino , Vignolini Pamela , Noce Annalisa
Published: December 2023

Background: Extra virgin olive oil is a typical food of the Mediterranean area, obtained by pressing Olea europaea L. fruits. Its polyphenols have been studied for their antioxidant function and protective action against cancer and chronic kidney disease. In this in vitro study, we tested titrated extracts from Olea europaea L. on a human embryonic kidney 293 (HEK-293E) cell line, regarding their pro-apoptotic and antiproliferative capacities, using “ IncuCyte® S3 Live-Cell Analysis System”. Materials and Methods: We selected Olea europaea L. active compounds like hydroxytyrosol (HT) and oleuropein (OLE). These extracts were tested at different concentrations and characterized by HPLC-DAD-MS for the content in secondary active metabolites. The real-time observation of cell behavior was performed by IncuCyte, which can quantitatively analyze the cell proliferation and death. Results: This study showed that all the tested extracts can significantly inhibit cellular growth at 50 µM but the reduced proliferation is not related to an increase in cellular apoptosis. Instead, the same analysis performed by using extracts at 100 µM reveals that they can inhibit cellular growth, further inducing cellular apoptosis. Conclusions: The results on the HEK-293E cells confirmed the antiproliferative and proapoptotic actions of active compounds from an Olea europaea L. matrix in this cell line.
Potential Parasitoids for Biocontrol of the Ber Fruit Fly, Carpomya vesuviana Costa (Diptera: Tephritidae)
Authors: Amini Alieh , Lotfalizadeh Hossein , Peris-Felipo Francisco Javier , Rasplus Jean-Yves
Published: December 2023

The ber fruit fly (BFF), Carpomya vesuviana Costa, 1854 (Diptera: Tephritidae), is an important key pest of the jujube, Ziziphus jujuba Miller. The main control measures against this pest are to use chemical control, but the first survey for its natural enemies was performed in Iran. Here, we report eight species of parasitic wasps of the BFF from five different families. The family Eurytomidae with three species, the families Pteromalidae and Mutillidae with two species each, and the families Braconidae and Diapriidae with one species each are associated with different immature stages of the BFF, of which Eurytoma pineticola Zerova (Eurytomidae) and Cyrtoptyx lichtensteini (Masi) (Pteromalidae) were the most abundant parasitoid species. Fopius carpomyiae (Silvestri,) was not reared on BFF on the jujube during this survey, but it was reported on Ziziphus spina-christi (L.) with a high parasitism rate. Therefore, it seems to be the most important parasitoid of BFF in Iran. The parasitoid community of BFF in Khorasan, Eastern Iran, is reviewed, and an identification key to these species is proposed.
New Insights into the Link between SARS-CoV-2 Infection and Renal Cancer
Authors: Rago Vittoria , Bossio Sabrina , Lofaro Danilo , Perri Anna , Di Agostino Silvia
Published: December 2023

Cancer has been described as a risk factor for greater susceptibility to SARS-CoV-2 infection and severe COVID-19, mainly for patients with metastatic disease. Conversely, to that reported for most solid and hematological malignancies, the few available clinical studies reported that the infection did not increase the risk of death in renal cancer patients. The expression on proximal tubular renal cells of the key players in cellular viral uptake, ACE2, TMPRSS2, and NRP1, seems to be the mechanism for the direct kidney injury seen in patients with COVID-19. Interestingly, data from The Cancer Genome Atlas and experimental analyses on various renal cancer cell lines demonstrated that the above-reported receptors/cofactors are maintained by renal cancer cells. However, whether SARS-CoV-2 infection directly kills renal cancer cells or generates enhanced immunogenicity is a question worth investigating. In addition, some researchers have further addressed the topic by studying the expression and prognostic significance of gene signatures related to SARS-CoV-2 infection in renal cancer patients. The emerging data highlights the importance of better understanding the existence of a link between renal cancer and COVID-19 since it could lead to the identification of new prognostic factors and the development of new therapeutic targets in the management of renal cancer patients.
Effectiveness of Novel Sympathetic Nerve Entrapment Point Injections for Chronic Migraine: A Pilot Study
Authors: Seong Jeong Won , Kim Yuntae , Kwon Dong Rak , Yang Cheol-Jung , Özçakar Levent
Published: December 2023

No studies to date have investigated the ability of sympathetic nerve entrapment point saline (SNEP) injections to achieve long-term pain relief in patients with migraine. Therefore, this study aimed to investigate the safety and long-term efficacy of repeat splenius capitis (SC) SNEP injections in patients with migraine (with/without tension-type headache). This retrospective, single-arm study included 12 patients with migraine. Isotonic saline was injected into their SC approximately six times for 3 months. Headache frequency, duration (hour/week), intensity (using the visual analog scale), and quality of life (using the Headache Impact Test-6) were assessed during the follow-up visits for up to 24 months after the first injection. Changes before and after treatment were assessed using repeated-measures analysis of variance. Significant reductions in headache frequency, duration, and intensity were observed at all assessment points after SNEP injections when compared with the baseline values (p < 0.05), while the patients’ headache-related quality of life also improved. Treatment was continued for up to 3 months to maintain these improvements, and no worsening of status or adverse effects were observed in any of the patients over the following 24 months. Our results show that SNEP injections may offer persistent, substantial, and clinically relevant benefits in patients with migraine.
Enhancing City Logistics for Sustainable Development in Jordan: A Survey-Based Study
Authors: Alnsour Jamal , Arabeyyat Abdullah Radwan , Al-Hyari Khalil , Al-Bazaiah Sakher A. I. , Aldweik Reeman
Published: December 2023

Background: The global concern for the environment and sustainable development goals has led to a growing focus on the increasing activities of city logistics. This research study aims to evaluate the current state of city logistics within the framework of sustainable development and analyze the key factors that impact the efficient management of city logistics in Jordan. Methods: To achieve these research objectives, a quantitative approach utilizing a survey questionnaire was employed. The findings emphasize a significant disparity between current practices in city logistics and desired outcomes, indicating an urgent need for improvement in cost reduction, enhancement of quality of life, and promotion of sustainability. Results: The results reveal that the performance of urban authorities in managing city logistics is influenced by various factors, including regulatory inefficiencies, suboptimal human resource performance, deficiencies in information systems, and challenges related to coordination amongst stakeholders. Conclusions: Consequently, this paper puts forth actionable recommendations for improving city logistics management, which involve amending existing regulations, implementing comprehensive training programs for employees, strengthening infrastructure for information systems, and fostering robust communication channels between urban authorities and stakeholders.
Ultra-Smooth Polishing of Single-Crystal Silicon Carbide by Pulsed-Ion-Beam Sputtering of Quantum-Dot Sacrificial Layers
Authors: Qiao Dongyang , Shi Feng , Tian Ye , Zhang Wanli , Xie Lingbo , Guo Shuangpeng , Song Ci , Tie Guipeng
Published: December 2023

Single-crystal silicon carbide has excellent electrical, mechanical, and chemical properties. However, due to its high hardness material properties, achieving high-precision manufacturing of single-crystal silicon carbide with an ultra-smooth surface is difficult. In this work, quantum dots were introduced as a sacrificial layer in polishing for pulsed-ion-beam sputtering of single-crystal SiC. The surface of single-crystal silicon carbide with a quantum-dot sacrificial layer was sputtered using a pulsed-ion beam and compared with the surface of single-crystal silicon carbide sputtered directly. The surface roughness evolution of single-crystal silicon carbide etched using a pulsed ion beam was studied, and the mechanism of sacrificial layer sputtering was analyzed theoretically. The results show that direct sputtering of single-crystal silicon carbide will deteriorate the surface quality. On the contrary, the surface roughness of single-crystal silicon carbide with a quantum-dot sacrificial layer added using pulsed-ion-beam sputtering was effectively suppressed, the surface shape accuracy of the Ø120 mm sample was converged to 7.63 nm RMS, and the roughness was reduced to 0.21 nm RMS. Therefore, the single-crystal silicon carbide with the quantum-dot sacrificial layer added via pulsed-ion-beam sputtering can effectively reduce the micro-morphology roughness phenomenon caused by ion-beam sputtering, and it is expected to realize the manufacture of a high-precision ultra-smooth surface of single-crystal silicon carbide.
Unveiling the Potential of Corn Cob Biochar: Analysis of Microstructure and Composition with Emphasis on Interaction with NO2
Authors: Drané Méghane , Zbair Mohamed , Hajjar-Garreau Samar , Josien Ludovic , Michelin Laure , Bennici Simona , Limousy Lionel
Published: December 2023

In the context of sustainable solutions, this study examines the pyrolysis process applied to corn cobs, with the aim of producing biochar and assessing its effectiveness in combating air pollution. In particular, it examines the influence of different pyrolysis temperatures on biochar properties. The results reveal a temperature-dependent trend in biochar yield, which peaks at 400 °C, accompanied by changes in elemental composition indicating increased stability and extended shelf life. In addition, high pyrolysis temperatures, above 400 °C, produce biochars with enlarged surfaces and improved pore structures. Notably, the highest pyrolysis temperature explored in this study is 600 °C, which significantly influences the observed properties of biochars. This study also explores the potential of biochar as an NO2 adsorbent, as identified by chemical interactions revealed by X-ray photoelectron spectroscopy (XPS) analysis. This research presents a promising and sustainable approach to tackling air pollution using corn cob biochar, providing insight into optimized production methods and its potential application as an effective NO2 adsorbent to improve air quality.
Preparation and Characterization of Calcium Carbonate Masterbatch–Alkali Soluble Polyester/Polyester Porous Fiber via Melt Spinning
Authors: Zhao Yanjiao , Song Ruochen , Pan Runan , Zhang Meiling , Liu Lifang
Published: December 2023

Porous fibers have gained significant attention for their lightweight and high porosity properties in applications such as insulation and filtration. However, the challenge remains in the development of cost-effective, high-performance, and industrially viable porous fibers. In this paper, porous fibers were fabricated through the melt spinning of an alkali soluble polyester (COPET)– CaCO3 masterbatch and PET slice. Controlled alkali and acid post-treatment techniques were employed to create porous structures within the fibers. The effects on the morphology, mechanical, thermodynamic, crystallinity, pore size, and thermal stability were investigated. The results indicate that the uniform dispersion of CaCO3 particles within the fiber matrix acts as nucleating agents during the granulation process, improving the thermal resistance and strength of the porous fiber. In addition, the porous fiber prepared by COPET/CaCO3 to PET with an 85/15 ratio and post-treated on 4% NaOH and 3% HCl exhibits a “spongy body” with uniformly small pores, favorable strength (2.71 cN/dtex), and elongation at break (47%).
Interface Mechanics of Double-Twisted Hexagonal Gabion Mesh with Coarse-Grained Filler Based on Pullout Test
Authors: Gao Wenhui , Lin Yuliang , Wang Xin , Zhou Tianya , Zheng Chaoxu
Published: December 2023

The interface friction mechanics of reinforcement material with filler is an essential issue for the engineering design of reinforced soil structure. The interface friction mechanics is closely associated with the properties of filler and reinforcement material, which subsequently affects the overall stability. In order to investigate the interface mechanism of a double-twisted hexagonal gabion mesh with a coarse-grained filler derived from a weathered red sandstone, a large laboratory pullout test was carried out. The pullout force–displacement curve was obtained by fully mobilizing the gabion mesh to reach the peak shear stress at the interface between the gabion mesh and the coarse-grained filler. The change of force–displacement characteristics and the distribution of tensile stress in gabion mesh during the pullout process were obtained. A 3D numerical model was established based on the pullout test model, and the model for analyzing the interface characteristic between the gabion mesh and the coarse-grained filler was modeled using the FLAC3D 6.0 platform. The interface characteristics were further analyzed in terms of the displacement of soil, the displacement of reinforcement, and the shear stress of soil. The strength and deformation behaviors of the interface during the entire pullout process were well captured. The pullout force–displacement curve experiences a rapid growth stage, a development transition stage and a yielding stabilization stage. The critical displacement corresponding to peak pullout stress increases with the increase in normal stress. The normal stress determines the magnitude of shear stress at the reinforcement and soil interface, and the displacement distribution of a gabion mesh is not significantly affected by normal stress when the applied normal stress is within a range of 7–20 kPa. The findings are beneficial to engineering design and application of a gabion mesh-reinforced soil structure.
Damage Generated and Propagated by the AAR Reactive Aggregate from Kingston, Ontario, Canada
Authors: Trottier Cassandra , Sanchez Leandro F. M.
Published: December 2023

It remains unclear in the literature what the cause of the so-called alkali–carbonate reaction (ACR) damage to concrete is. However, expansion and cracks as distress features are often attributed to the alkali–silica reaction (ASR). Therefore, this work aims to assess the damage to concrete generated and propagated by the so-called ACR-susceptible reactive aggregate through mechanical testing (i.e., the direct shear test), microscopy (the damage rating index—DRI), and other techniques. Distinct induced expansion levels (i.e., 0%, 0.05%, 0.12%, and 0.20%) were selected to compare the distress caused by ACR to concrete affected by ASR. The results show that the behavior of ACR, namely, as captured through the DRI, is inconsistent with that of ASR, thus attesting to ACR being a distinct distress mechanism. The damage captured through mechanical testing does not distinguish ACR from ASR; however, microscopy reveals that cracks in the cement paste are the main damage mechanism. The proportions of cracks in the cement paste are 40–50% of the total number of cracks, whereas open cracks in the aggregates normally characterizing ASR represent only up to 20% of the total cracks.
Growth of Ga0.70In0.30N/GaN Quantum-Wells on a ScAlMgO4 (0001) Substrate with an Ex-Situ Sputtered-AlN Buffer Layer
Authors: Zheng Dong-Guang , Min Sangjin , Kim Jiwon , Han Dong-Pyo
Published: December 2023

This study attempted to improve the internal quantum efficiency (IQE) of 580 nm emitting Ga0.70In0.30N/GaN quantum-wells (QWs) through the replacement of a conventional c-sapphire substrate and an in-situ low-temperature GaN (LT-GaN) buffer layer with the ScAlMgO4 (0001) (SCAM) substrate and an ex-situ sputtered-AlN (sp-AlN) buffer layer, simultaneously. To this end, we initially tried to optimize the thickness of the sp-AlN buffer layer by investigating the properties/qualities of an undoped-GaN (u-GaN) template layer grown on the SCAM substrate with the sp-AlN buffer layer in terms of surface morphology, crystallographic orientation, and dislocation type/density. The experimental results showed that the crystallinity of the u-GaN layer grown on the SCAM substrate with the 30 nm thick sp-AlN buffer layer [GaN/sp-AlN(30 nm)/SCAM] was superior to that of the conventional u-GaN template layer grown on the c-sapphire substrate with an LT-GaN buffer layer (GaN/LT-GaN/FSS). Notably, the experimental results showed that the structural properties and crystallinity of GaN/sp-AlN(30 nm)/SCAM were considerably different from those of GaN/LT-GaN/FSS. Specifically, the edge-type dislocation density was approximately two orders of magnitude higher than the screw-/mixed-type dislocation density, i.e., the generation of screw-/mixed-type dislocation was suppressed through the replacement, unlike that of the GaN/LT-GaN/FSS. Next, to investigate the effect of replacement on the subsequent QW active layers, 580 nm emitting Ga0.70In0.30N/GaN QWs were grown on the u-GaN template layers. The IQEs of the samples were measured by means of temperature-dependent photoluminescence efficiency, and the results showed that the replacement improved the IQE at 300 K by approximately 1.8 times. We believe that the samples fabricated and described in the present study can provide a greater insight into future research directions for III-nitride light-emitting devices operating in yellow–red spectral regions.
Tribological Properties and Lubrication Mechanisms of Water-Based Nanolubricants Containing TiO2 Nanoparticles during Micro Rolling of Titanium Foils
Authors: Ma Linan , Ma Luhu , Ma Xiaoguang , Zhou Cunlong , Jiang Zhengyi , Zhao Jingwei
Published: December 2023

The tribological behavior of traditional oil-in-water (O/W) lubricants (1.0 wt.%) and nano-TiO2 additive lubricants (1.0–9.0 wt.%) during micro rolling of titanium foils were analyzed. In this study, the surface morphologies of titanium foils under various lubrication conditions were assessed, and the corresponding lubrication mechanisms were revealed. The tribological behavior of nano-TiO2 additive lubricants during micro rolling of titanium foils was also explored through a series of characterization methods. The utilization of nano-TiO2 additive lubricants in micro rolling reduces the surface roughness of titanium foils. Moreover, it effectively inhibits the generation of indentations and cracks during rolling processes, enhancing the surface quality of rolled specimens. Additionally, owing to the synergism of rolling, tribo-film, mending and polishing effects of the nanoparticles, both the rolling force and surface roughness were minimized by using lubricants containing 3.0 wt.% TiO2 nanoparticles. Overall, an optimal concentration (3.0 wt.%) of TiO2 nanoparticles in water-based nanolubricants was obtained with enhanced tribological properties and lubrication performance during micro rolling of titanium foils.
Comprehensive Understanding of the Effect of TGO Growth Modes on Thermal Barrier Coating Failure Based on a Simulation
Authors: Qiao Da , Man Jixin , Yan Wengao , Xue Beirao , Bian Xiangde , Zeng Wu
Published: December 2023

The growth stress induced by thermally grown oxide (TGO) is one of the main reasons for the failure of thermal barrier coatings (TBCs). In this study, the failure behavior of TBCs was examined based on different growth modes of TGO. A TBC thermo-mechanical model with a simplified sinusoidal interface morphology was established by the secondary development of a numerical simulation. The plasticity and creep behavior of materials were considered. Based on the subroutine development, the non-uniform growth of the TGO layer was realized. Cohesive elements were also applied to the TC/TGO interface. The stress distribution and evolution at the TC/TGO interface were investigated. Then, the cracking behavior near the interface was studied. The results show that lateral growth causes the off-valley site to replace the previous off-peak site as a vulnerable site. The non-uniform growth accelerates damage in the off-valley site, which leads to a change in the failure behavior. These results will provide significant guidance for understanding the TBC failure and the development of advanced TBCs.
The Effect of Micron-Sized TiB2 Particles on the Properties of Al6061 Strengthened with 4% TiB2 Nano-TiB2
Authors: Zheng Xinbing , Long Wei , Zhu Changshun , Zhao Longbin , Hu Xinbin , Liu Sheng , Jiang Wenming , Peng Yaxiong
Published: December 2023

Dual-scale (nano and micron) particle-reinforced TiB2/6061Al matrix composites with different contents of TiB2 were prepared using powder metallurgy, and then analyzed via microstructure observation and tests of microhardness, tensile properties, and friction and wear properties. The 6061Al powders’ particles changed from spherical to flaky after two rounds of high-energy ball milling, and the TiB2 enhancer was embedded in or wrapped by the matrix particles after high-energy ball milling. Metallurgical bonding between TiB2 particles and the matrix was achieved, and Al3Ti was synthesized in situ during sintering. The hot-pressing process eliminated the internal defects of the composites, and the TiB2 particles were diffusely distributed in the matrix. The best comprehensive mechanical properties (hardness and tensile strength) were achieved when the mass fraction of TiB2 was 5% (1% micron + 4% nano); the hardness and tensile strength of the composites reached 131 HV and 221 MPa—79.5% and 93.9% higher than those of the pure matrix, respectively. The composites’ average coefficient of friction and volumetric wear rate were reduced. Composites with a TiB2 mass fraction of 7% (3% micron + 4% nano) had the highest average coefficients of friction and the lowest volumetric wear rate of 0.402 and 0.216 mm3∙N−1∙m−1, respectively. It was observed that adhesion influences the friction mechanism, which transitions from adhesive wear with slight oxidative wear to abrasive wear.
Comparison of Thermal Behaviors of Carbon and Stainless Steel Billets during the Heating Process
Authors: Hwang Joong-Ki
Published: December 2023

The effect of thermal properties on the thermal behavior of a steel billet was investigated during the heating process to understand each effect and to provide process engineers with sufficient data to choose the optimal design conditions in reheating the furnace for hot rolling. Carbon steel and austenitic stainless steel (STS) were compared based on numerical simulations owing to the completely different thermal properties of these two steels: carbon steel having a phase transformation with a relatively high thermal conductivity and STS having no phase transformation with a relatively low thermal conductivity. The thermal conductivity affected the thermal behavior of the billet in the initial stage of heating owing to the high temperature difference between the surface of the billet and the gas in the furnace, i.e., the high Biot number. Accordingly, a non-firing zone and/or a preheating zone with a low gas temperature are necessary for high-alloyed steels including STS because the thermal conductivity of these steels is relatively low. The phase transformation of the carbon steels needs to occur in the primary heating zone, and this zone needs to have a relatively low gas temperature to reduce the temperature deviation or thermal stress in the billet. The heating pattern of the carbon steels and STSs in the reheating furnace should be designed differently considering the thermal conductivity and latent heat by the phase transformation of steels to obtain a high heating quality for the billet.
GSA-KELM-KF: A Hybrid Model for Short-Term Traffic Flow Forecasting
Authors: Chai Wenguang , Zhang Liangguang , Lin Zhizhe , Zhou Jinglin , Zhou Teng
Published: December 2023

Short-term traffic flow forecasting, an essential enabler for intelligent transportation systems, is a fundamental and challenging task for dramatically changing traffic flow over time. In this paper, we present a gravitational search optimized kernel extreme learning machine, named GSA-KELM, to avoid manually traversing all possible parameters to improve the potential performance. Furthermore, with the interference of heavy-tailed impulse noise, the performance of KELM may be seriously deteriorated. Based on the Kalman filter that cleverly combines observed data and estimated data to perform the closed-loop management of errors and limit the errors within a certain range, we propose a combined model, termed GSA-KELM-KF. The experimental results of two real-world datasets demonstrate that GSA-KELM-KF outperforms the state-of-the-art parametric and non-parametric models.
Blockchain Adoption and Organic Subsidy in an Agricultural Supply Chain Considering Market Segmentation
Authors: Li Chunmei , Yang Tianjian , Shi Ying
Published: December 2023

The quality authenticity of organic agricultural products has always been a hot issue for consumers. Blockchain’s advantages in information traceability and preventing data from being tampered with can reduce fake and counterfeit products, increasing the consumers’ trust in the quality of organic agricultural products. Considering market segmentation of consumer types in organic agricultural products (OPs) and conventional agricultural products (CPs), this study builds a game-theoretical model to explore how participants decide between blockchain traceability platforms and organic subsidy strategies. Results show that the producer should introduce the blockchain when the fraction of blockchain technology’s total cost shared by the producer is smaller and the fixed cost of implementing blockchain is higher or when the fraction of blockchain technology’s total cost shared by the producer is higher and the fixed cost of implementing blockchain is lower. The retailer is inclined to an organic subsidy, and the smaller the market proportion of undifferentiated-conscious consumers (UCCs), the more inclined the retailer is to the organic subsidy strategy. In addition, the market share of UCCs positively promotes the sales quantities and supply chain profits of CPs but is not conducive to the sales quantities of OPs.
About an Unsolved Problem of Stabilization by Noise for Difference Equations
Authors: Shaikhet Leonid
Published: December 2023

The paper is devoted to the effect of “stabilization by noise”. The essence of this effect is that an unstable deterministic system is stabilized by stochastic perturbations of sufficiently high intensity. The problem is that the effect of “stabilization by noise”, well-known already for more than 50 years for stochastic differential equations, still has no analogue for stochastic difference equations. Here, a corresponding hypothesis is formulated and discussed, the truth of which is illustrated and confirmed by numerical simulation of solutions of stochastic linear and nonlinear difference equations. However, a problem of a formal proof of this hypothesis remains open.
Trigonometric Induced Multivariate Smooth Gauss–Weierstrass Singular Integrals Approximation
Authors: Anastassiou George A.
Published: December 2023

In this article, we employ the uniform and Lp, 1≤p<∞ approximation properties of general smooth multivariate singular integral operators over RN, N≥1. It is a trigonometric relief approach with detailed applications to the corresponding smooth multivariate Gauss–Weierstrass singular integral operators. The results are quantitative via Jackson-type inequalities involving the first uniform and Lp moduli of continuity.
Unmasking a Silent Threat: Improving Pulmonary Hypertension Screening Methods for Interstitial Lung Disease Patients
Authors: Averjanovaitė Vaida , Gumbienė Lina , Zeleckienė Ingrida , Šileikienė Virginija
Published: December 2023

This article provides a comprehensive overview of the latest literature on the diagnostics and treatment of pulmonary hypertension (PH) associated with interstitial lung disease (ILD). Heightened suspicion for PH arises when the advancement of dyspnoea in ILD patients diverges from the expected pattern of decline in pulmonary function parameters. The complexity of PH associated with ILD (PH-ILD) diagnostics is emphasized by the limitations of transthoracic echocardiography in the ILD population, necessitating the exploration of alternative diagnostic approaches. Cardiac magnetic resonance imaging (MRI) emerges as a promising tool, offering insights into hemodynamic parameters and providing valuable prognostic information. The potential of biomarkers, alongside pulmonary function and cardiopulmonary exercise tests, is explored for enhanced diagnostic and prognostic precision. While specific treatments for PH-ILD remain limited, recent studies on inhaled treprostinil provide new hope for improved patient outcomes.
Muscle-Derived Stem/Progenitor Cells Ameliorate Acute Kidney Injury in Rats through the Anti-Apoptotic Pathway and Demonstrate Comparable Effects to Bone Marrow Mesenchymal Stem Cells
Authors: Pavyde Egle , Usas Arvydas , Pockevicius Alius , Maciulaitis Romaldas
Published: December 2023

Background and Objectives: To date, the therapeutic potential of skeletal muscle-derived stem/progenitor cells (MDSPCs) for acute kidney injury (AKI) has only been evaluated by our research group. We aimed to compare MDSPCs with bone marrow mesenchymal stem cells (BM-MSCs) and evaluate their feasibility for the treatment of AKI. Materials and Methods: Rats were randomly assigned to four study groups: control, GM (gentamicin) group, GM+MDSPCs, and GM+BM-MSCs. AKI was induced by gentamicin (80 mg/kg/day; i.p.) for 7 consecutive days. MDSPCs and BM-MSCs were injected 24 h after the last gentamicin injection. Kidney parameters were determined on days 0, 8, 14, 21, and 35. Results: MDSPCs and BM-MSCs accelerated functional kidney recovery, as reflected by significantly lower serum creatinine levels and renal injury score, higher urinary creatinine and creatinine clearance levels (p < 0.05), lower TUNEL-positive cell number, and decreased KIM-1 and NGAL secretion in comparison to the non-treated AKI group. There was no significant difference in any parameters between the MDSPCs and BM-MSCs groups (p > 0.05). Conclusions: MDSPCs and BM-MSCs can migrate and incorporate into injured renal tissue, resulting in a beneficial impact on functional and morphological kidney recovery, which is likely mediated by the secretion of paracrine factors and an anti-apoptotic effect. MDSPCs were found to be non-inferior to BM-MSCs and therefore can be considered as a potential candidate strategy for the treatment of AKI.