bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effect of Neem (Azadirachta indica) Gum Administration to Malondialdehyde Level of Wistar Rats’ Kidney Induced by Diazinon
Authors: Firdaus Jauhar , Putri Radinta Maharani , Efendi Erfan , Hermansyah Yuli , Sakinah Elly Nurus
Published: March 2023

Diazinon is the most commonly used pesticide in Indonesia. It may increase the production of free radicals that triggers the lipid peroxidation process which will produce the final product, MDA, which can damage cells and tissues, especially the kidneys. Neem gum with its high polysaccharide is a good antioxidant agent to neutralize free radicals. The purpose of this study was to determine the effect of neem gum administration to prevent the increase in kidney MDA levels of wistar rats induced by diazinon. Thirty wistar rats were divided into 6 groups, K0 (given cornoil), K1 (induced DZN 40 mg/kgBW), groups P1, P2, P3, and P4, administered with neem gum as a drinking water at a dose 3.75 g/kgBW, 7.5 g/kgBW, 15 g/kgBW, and 30 g/kgBW and induced by DZN 40 mg/kgBW. The treatment was carried out for 8 days, in which diazinon induction and neem gum solution were administered simultaneously. The average renal MDA levels are K0=20.85±1.10; K1=26.98±5.87; P1=26.84±3.75; P2=21.43±3.44; P3=20.23±3.27; P4=21.99±1.70. One Way ANOVA test showed a significant difference (p<0.05). The LSD posthoc test showed a significant difference in the treatment groups P2, P3, and P4 compared to the K1 group (p<0.05). This shows that the neem gum solution at a dose of 7.5 g/kgBW, 15 g/kgBW, and 30 g/kgBW can prevent the increase of kidney MDA level in wistar rats induced by diazinon.

Keywords: Pesticide, oxidative stress, Antioxidant, Neem gum
Increased of IL-4 and Ig E Level in Infection Hookworm in Plantation Workers in Jember
Authors: Hermansyah Bagus , Armiyanti Yunita , Utami Wiwien Sugih
Published: March 2023

Hookworm infection is a disease that is included in the neglected tropical disease. Hookworm infection is suffered by many plantation workers who are closely related to the soil in daily life. Immune response in hookworm-infected individuals will experience disorders, especially in eosinophilia, mastocytosis, and IgE stimulation. It is therefore important to know the immune response to hookworm infections in plantation workers. In this study, eosinophilia was calculated on peripheral blood smears and counts of IL-4 and Ig-E levels by ELISA. The results showed an increase in eosinophil levels from blood samples of patients and a significant increase in IL-4 and IgE levels based on the results of statistical analysis.

Keywords: hookworm, plantation worker, IL-4, and IgE
Treino de Simulação em Saúde: A Perspetiva Atual acerca das Técnicas de Discussão
Authors: Amorim João Pedro , Ribeiro Florinda
Published: March 2023

N/a.
Pembuatan Video Tutorial Avatar Dengan Teknik Glow In The Dark Make Up Look Pada Mata Kuliah Tata Rias Fantas
Authors: Agustiani Safitri Charina , Lilis Jubaedah
Published: March 2023

ABSTRAK

 

Charina Agustiani Safitri, Pembuatan Video Tutorial Avatar Dengan Teknik Glow In The Dark Make Up Look Pada Mata Kuliah Tata Rias Fantasi, Tugas akhir : Jakarta Program Studi Diploma 3 Tata Rias, Fakultas Teknik, Universitas Negeri Jakarta, 2022.

 

Face painting glow in the dark merupakan salah satu media yang populer didunia fashion, makeup, hair, tattoo dan banyak lainnya. Dalam proses pembuatannya Avatar dengan teknik Glow In The Dark membutuhkan 3 bahan utama, diantarnya scar wax, Uv painting, dan Led Uv Light. Penelitian ini dilakukan dengan tujuan untuk membantu proses pembelajaran dan menambah ilmu bagi peneliti juga pembaca dalam video tutorial Avatar dengan teknik Glow In The Dark. Penilaian video tutorial Avatar dengan teknik Glow In The Dark dilakukan dengan uji kelayakan oleh 2 ahli, yaitu ahli materi dan ahli media dengan aspek penilaian sebagai berikut taitu aspek isi, aspek visual, aspeuk audio, aspek bahasa, dan aspek tipografi. Berdasarkan penilaian dengan ahli materi dan ahli media. “Pembuatan Video Tutorial Avatar Dengan Teknik Glow In The Dark Make Up Look Pada Mata Kuliah Tata Rias Fantasi”, memproleh hasil presentase keduanya sebanyak 96% dan dinyatakan sangat layak.
Identificación y frecuencia de parásitos intestinales con potencial zoonótico en caninos con propietario del caserío de Picup, Independencia, Áncash, Perú
Authors:   , Callán Sánchez Milagros Rosicela
Published: March 2023

El objetivo de la presente investigación fue determinar la frecuencia de parásitos intestinales con potencial zoonótico en caninos con dueño en el caserío de Picup del distrito de Independencia, Áncash. La investigación fue de tipo prospectivo, transversal y descriptiva. Se colectaron 105 muestras de heces de caninos, que fueron procesadas mediante las técnicas coprológicas: método directo, sedimentación rápida, flotación de Sheater y tinción de Ziehl Neelsen. Se identificaron los géneros parasitarios según la morfología de sus huevos. La frecuencia de parásitos intestinales fue de 65.7% (69/105), correspondientes a Ancylostoma spp. (72.5%, IC 38 – 57.2), Toxocara canis (24.6 %, IC 9.1 – 23.2), Trichuris vulpis (16.0 %, IC 4.6 – 16.3), Dipylidium caninum (11.6%, IC 2.5 – 12.7), Cystoisospora sp. (11.6 %, IC 2.5 – 12.7), Cryptosporodium sp. (1.4%, IC 0 – 2.8) y Fasciola hepatica (1.4 %, IC 0 – 2.8). Se encontró asociación estadísticamente significativa (p<0,05) entre las variables sexo y desparasitación externa respecto a la parasitosis intestinal. Los géneros con potencial zoonótico corresponden a Ancylostoma spp., Toxocara canis, Dipylidium caninum, Cryptosporidium sp. y Fasciola hepatica.
Performance Analysis of NOMA Systems with Imperfect SIC in Cooperative Cognitive Radio Networks
Authors: M Chitra , Dhanasekaran Senthilkumar
Published: March 2023

This paper presents non-orthogonal multiple access (NOMA)-based spectrum sharing scheme for cooperative underlay cognitive radio (CR) wherein the cell-edge primary receiver (CE-PR) can decode the symbols in every time slot by exploiting cooperative multiplexing. In the proposed scheme, the secondary receiver is employed as a cooperative node to achieve a full-duplexing rate at the primary network. Due to this fact and the absence of interference from the primary network, the performance of the secondary network suffers only from self-loop interference (SI). On the other hand, since the secondary transmitter (ST) is not transmitting simultaneously with the primary transmitter, CE-PR can receive the symbol from the direct link without ST interference. In this paper, we derive the closed-form expression for computing the outage probability and the sum rate of the proposed system under imperfect successive interference cancellation (SIC). For comparison purposes, we present the rate and outage performance of the orthogonal multiple access (OMA)-based underlay CR.
SE(3) Group Convolutional Neural Networks and a Study on Group Convolutions and Equivariance for DWI Segmentation
Authors: Liu Renfei , Lauze Francois , Bekkers Erik , Erleben Kenny , Darkner Sune
Published: March 2023

We present an SE(3) Group Convolutional Neural Network along with a series of networks with different group actions for segmentation of Diffusion Weighted Imaging data. These networks gradually incorporate group actions that are natural for this type of data, in the form of convolutions that provide equivariant transformations of the data. This knowledge provides a potentially important inductive bias and may alleviate the need for data augmentation strategies. We study the effects of these actions on the performances of the networks by training and validating them using the diffusion data from the Human Connectome project. Unlike previous works that use Fourier-based convolutions, we implement direct convolutions, which are more lightweight. We show how incorporating more actions - using the SE(3) group actions - generally improves the performances of our segmentation while limiting the number of parameters that must be learned.
Long-term effects of thinning on non-structural carbohydrate and stoichiometric characteristics of Pinus yunnanensis
Authors: Li Chaojun , Jing Huiqing , Liang Siyi , Tan Tian , Guo Wanquan , Yang Jianfeng , Yang Conghui , Han Chengjin , Wu Junwen
Published: March 2023

The effects of long-term thinning on the nonstructural carbohydrates (NSC) and stoichiometry of trees are poorly understood. Here, root, stem, and leaf samples were collected from a middle-aged Pinus yunnanensis forest thinned in 2012 to determine the content of carbon (C), nitrogen (N), phosphorus (P), sugar, and starch. Our findings revealed that (1) the NSC of the roots and needles increased by 18.94% and 46.95% after thinning, respectively. (2) The P content increased by 36.30%, 63.50%, and 52.16% in the roots, stems, and needles after thinning, respectively. (3) Thinning had no significant effect on the N content in any organ. (4) Long-term thinning affected the distribution of soluble sugars and starches, as well as the content of C and P in different organs. (5) The N:P ratio was 17.96 in the control group and 12.32 in the thinned group, which indicates that P and N were limited in the former and latter, respectively. (6) The phenotypic plasticity index of the stoichiometric characteristics of P. yunnanensis after thinning was lower than that of NSC, and the coefficients of variation of these characteristics in the stems were larger than the coefficients of variation of these characteristics in the organs. Thinning altered the distribution of C and P among the organs, and the stand changed from P-limited to N-limited after thinning. Our findings suggest that appropriate applications of N fertilizer after thinning would improve the quality of the stand.
Polygenic risk of Social-isolation and its influence on social behavior, psychosis, depression and autism spectrum disorder
Authors: Socrates Adam , Mullins Niamh , Gur Ruben , Gur Raquel , Stahl Eli , O’Reilly Paul , Reichenberg Abraham , Jones Hannah , Zammit Stan , Velthorst Eva
Published: March 2023

Social-isolation has been linked to a range of psychiatric issues, but the behavioral component that drives it is not well understood. Here, a GWAS is carried out to identify genetic variants which contribute to Social-isolation behaviors in up to 449,609 participants from the UK Biobank. 17 loci were identified at genome-wide significance, contributing to a 4% SNP heritability estimate. Using the Social-isolation GWAS, polygenic risk scores (PRS) were derived in ALSPAC, an independent, developmental cohort, and used to test for association with friendship quality. At age 18, friendship scores were associated with the Social-isolation PRS, demonstrating that the genetic factors are able to predict related social traits. LD score regression using the GWAS demonstrated genetic correlation with autism spectrum disorder, schizophrenia, and major depressive disorder. However, no evidence of causality was found using a conservative Mendelian randomization approach other than that of autism spectrum disorder on Social-isolation. Our results show that Social-isolation has a small heritable component which may drive those behaviors which is associated genetically with other social traits such as friendship satisfaction as well as psychiatric disorders.
Circulating apo B to A1 ratio reflects the progression of chronic heart failure with different etiologies
Authors: Zhou Qing Fen , Ren Yan , Dai Yang , Chen Shuai , Ding Feng Hua , Wang Xiao Qun , Zhang Feng Ru , Shen Wei Feng , Shen Ying , Lu Lin
Published: March 2023

Backgrounds:
Apolipoprotein (apo) B and apo A1 are major protein component of low-density lipoprotein and high-density lipoprotein particles, which are closely linked to lipid metabolism, atherosclerosis, and endothelial function. We sought to investigate whether circulating apoB/A1 ratio could serve as a potential metabolic risk factor for the progression of chronic heart failure (HF).
Methods
Serum levels of apo B and apo A1 were measured in 1299 consecutive patients with clinical symptoms of chronic HF. Left ventricular ejection fraction (EF) and E/e’ were determined by two-dimensional echocardiography and Doppler flow imaging using standard biplane technique. The relationship of apo B/A1 ratio to classification and etiology of HF was examined.
Results
Overall, apoB/A1 ratio was gradually decreased from HF with reduced EF (HFrEF), HF with mid-range reduced EF (HFmrEF), to HF with preserved EF (HFpEF), and correlated negatively with left ventricular EF (r=-0.162, p < 0.001)but positively with E/e’ (r = 0.147, P < 0.001). After adjustment for conventional factors, apoB/A1 ratio remained an independent risk factor for HFrEF or HFmrEF (P < 0.05). Further analysis revealed that apoB/A1 ratio was significantly associated with HF classification in patients whose HF was caused by hypertensive heart disease or ischemic cardiomyopathy (all p < 0.05),
Conclusions
In patients with chronic HF, elevated circulating apoB/A1 ratio confers an increased risk for worsened left ventricular dysfunction, especially for those with hypertensive heart disease or severe coronary artery disease.
Food security status of rural households in Makhado municipality of South Africa before and during the COVID-19 induced restrictions: HFIAS and HDDS approaches
Authors: Nevhutalu Thivhulawi , MAYEKISO ANELE , Gidi Lungile Sivuyile
Published: March 2023

The study aimed to analyse how COVID-19-induced restrictions have affected rural household food security in Makhado local municipality of Limpopo province. The study used purposive sampling and proportional random sampling, and primary data was collected from 139 rural households using a questionnaire. Household Food Insecurity Access Scale (HFIAS), Household Dietary Diversity Score (HDDS) and multiple linear regression model were used to analyse the effects of COVID-19-induced restrictions towards household food security. Based on the results, the study concludes that, food insecurity increased among rural households during the COVID-19 pandemic, and they were concerned about not having enough food. The COVID-19 pandemic robbed many people of their constitutionally protected right to sufficient food, weakening efforts to achieve "Zero Hunger" by 2030 under the National Development Plan and the United Nations Sustainable Development Goals.
Short-term effect of lengthened shank semi-hip replacement combined with wire ligation in the treatment of unstable intertrochanteric fracture of femur in elderly patients
Authors: Yuan Lingli , Tang Haoxu , Zhu Xunbing , Bai Jianzhong , Zhang Zhongchuan , Zheng Wenming , Liang Yingjie
Published: March 2023

[Objective] To investigate the short-term clinical effect of femoral lengthening biological stem half-hip replacement combined with large or small rotor reduction wire loop reconstruction in the treatment of unstable intertrochanteric fracture of the femur in the elderly.
[Methods] Thirty patients with unstable intertrochanteric fractures of the senile femur were treated by WangnerSL double-action head and half hip replacement with biological extension stem in the Second Affiliated Hospital of Bengbu Medical College from June 2018 to July 2021. The operative time, intraoperative blood loss, postoperative complications, and so on were recorded. VAS and hip Harris scores were used before surgery and 3 and 12 months after surgery. Hip radiographs were reviewed 1 week, 3, 6, 12, and 18 months after surgery to observe whether the prostheses were loose or sinking, and hip function was assessed.
[Results] All the operations were completed in this group. The average follow-up time was (12.5±6.5) months. Hip joints were stable after surgery, and no complications such as infection, dislocation, and loosening occurred. The Harris score rate was 83.3%, and the VAS score and Harris score showed a significant statistical difference.
[Conclusion] In the treatment of unstable intertrochanteric fracture of the elderly femur, femoral lengthening biological stem half-hip replacement combined with large or small rotor reduction wire ligation can shorten the bedtime of patients, promote the functional recovery of hip earlier, reduce the occurrence of bed complications, the clinical efficacy is satisfactory, and has good clinical application value.
Tdrd3-null mice show post-transcriptional and behavioral impairments associated with neurogenesis and synaptic plasticity
Authors: Zhu XingLiang , Joo Yuyoung , Bossi Simone , McDevitt Ross , Xie Aoji , Wang Yue , Xue Yutong , Su Shuaikun , Lee Seung Kyu , Sah Nirnath , Zhang Shiliang , Ye Rong , Pinto Alejandro , Zhang Yongqing , Araki Kimi , Araki Masatake , Morales Marisela , Mattson Mark , Praag Henriette van , Wang Weidong
Published: March 2023

The Topoisomerase 3B (Top3b) - Tudor domain containing 3 (Tdrd3) protein complex is the only dual-activity topoisomerase complex in animals that can alter the topology of both DNA and RNA. TOP3B mutations in humans are associated with schizophrenia, autism and cognitive disorders; and Top3b-null mice exhibit several phenotypes observed in animal models of psychiatric and cognitive disorders, including impairments in cognitive and emotional behaviors, aberrant neurogenesis and synaptic plasticity, and transcriptional defects. Similarly, human TDRD3 genomic variants have been associated with schizophrenia, verbal shorten-memory and learning, and educational attainment. However, the importance of Tdrd3 in normal brain function has not been examined in animal models. Here we built a Tdrd3-null mouse strain and demonstrate that these mice display both shared and unique defects when compared to Top3b-null mice. Shared defects were observed in cognitive behaviors, synaptic plasticity, adult neurogenesis, newborn neuron morphology, and neuronal activity-dependent transcription; whereas defects unique to Tdrd3-deficient mice include hyperactivity, changes in anxiety-like behaviors, increased new neuron complexity, and reduced myelination. Interestingly, multiple genes critical for neurodevelopment and cognitive function exhibit reduced levels in mature but not nascent transcripts. We infer that the entire Top3b-Tdrd3 complex is essential for normal brain function, and that defective post-transcriptional regulation could contribute to cognitive impairment and psychiatric disorders.
Factors Influencing Social Isolation Among Urban Empty-nest Youth in East China: A Qualitative Study
Authors: Yao Anling , Li Ling , Zhu Mingling
Published: March 2023

Background: Empty-nest youth are among the most vulnerable populations in society and they are prone to social isolation. Social isolation has a significant impact on empty-nest youth themselves and the society. Through an in-depth understanding of the main factors of social isolation among empty-nest youth in East China, this study aim to address their social isolation, ensure their psychological health and quality of life, and promote social integration.
Method: This study used descriptive qualitative research to conduct semi-structured interviews with 15 empty-nest youth between August and October 2021. We used directed content analysis on the resulting data.
Result: By combining, generalizing, and refining, we finally derive two main themes and eleven sub-themes. According to attribution theory, we divide results into internal factors (personality traits, internet dependence, upwards comparison mindset, social cognitive bias, lack of social adaptation ability, inadequate social skill) and external factors (social network relationship disconnection, insufficient urban concern, indifferent interpersonal relationship, heavy economic burden, work factor).
Conclusion: Factors contributing to social isolation among empty-nest youth are multifaceted. The study recommends that managers take appropriate measures to reduce the level of social isolation among empty-nest youth, safeguard their psychological health and quality of life, and promote social integration.
Nomogram model to predict the probability of spontaneous abortion in human assisted reproductive technology
Authors: Duan Xiaoyan , li Mingming , Ma Xing , Li Fei
Published: March 2023

Background: Spontaneous abortion is one of the most common complications of pregnancy in assisted reproductive technology (ART), it has become a thorny issue that poses a threat to pregnant women and their unborn children. Prevention is more important than treatment as for spontaneous abortion, Unfortunately, there is no accurate model to predict and prevent its occurrence.
Methods: This retrospective cohort study evaluated clinical data from 15,723 patients successfully conceived who underwent IVF/ICSI in the first people’s hospital of shangqiu and the affiliated hospital of zhengzhou university from december 2015 to February 2021. Patients were divided into an "abortion group" and a "non-abortion group" according to the outcome of abortion. We further performed a multi-factor and single-factor logistic regression analysis to determine the independent factors, then we establish nomogram model to avoid the occurrence of spontaneous abortion in ART patients based on the independent influencing factors.
Results: In this study, 15,723 patients had successfully conceived with ART, of which 2,336 patients (14.86%) had abortion, and 13,387 patients (85.14%) did not. Logistic regression analysis showed that female age (OR 1.050; 95% CI 1.029 ~ 1.061; P<0.001), male age (OR 1.102; 95% CI 1.086 ~ 1.115; P<0.001), follicle-stimulating hormone (OR 1.044; 95% CI 1.015 ~ 1.069; P<0.001), anti-Mullerian hormone (OR 0.891; 95% CI 0.862 ~ 0.925; P<0.001) were risk factors for spontaneous abortion. Then a nomogram model of abortion occurrence was constructed according to the above factors, and the AUC of the modeling group is 0.746 (95%CI 0.707-0.784), the AUC of the verification group is 0.718 (95%CI 0.999-0.737).
Conclusions: Our study found that female age, male age, follicle-stimulating hormone, anti-mullerian hormone were independent risk factors for spontaneous abortion, and the Nomogram model is an effective, simple and intuitive clinical model for predicting the probability of spontaneous abortion in ART.
Quality of Life of Mothers of Children born with Cleft Palate in Jordan
Authors: Qatamin Buthainah , EL-HNEITI Mamdouh , Shehadeh Jumna , Elfalah Mutasem , Hamdan-Mansour Ayman
Published: March 2023

The purpose of this paper was to investigate sociodemographic predictors of quality of life of mothers of children with cleft palate, and to compare quality of life between mothers of children without cleft palate and those of children without cleft palate in Jordan. A cross-sectional correlational study was conducted at one specialized Cleft Palate Unit using convenience sample of 312 mothers of children with and without cleft palate. The study used a self-reported questionnaire of two parts; socio-demographic; and WHOQOL- BREFF, Arabic version respectively. Analysis revealed that there was significant difference in environmental quality of life between mother with cleft palate child and those without cleft palate child. Mother’s physical quality of life was significantly predicted by their age, and educational level. Mother’s environmental quality of life was significantly predicted by their social status, and educational level. in conclusion mothers of children with CLP need psychosocial support at societal and institutional levels. Counselling and enhancement of positive coping mechanism are among the most important topics to be addressed to improve mothers' quality of life.
Probabilistic Seismic Hazard for the United Arab Emirates Using Integrated Seismic Source Model
Authors: Barakat Samer A. , Arab Mohamed G. , Awad Raghad A. , Malkawi Dima A. Husein , Metawa Abdulrahman , Omar Maher
Published: March 2023

Improving knowledge of active faults encouraged researchers to include faults as seismogenic sources in probabilistic seismic hazed assessments (PSHA). In the current study, a PSHA analysis for the United Arab Emirates (UAE) was conducted using faults along with area seismic sources utilizing a logic-tree framework. Seismicity is evaluated in terms of spectral acceleration (SA) and Peak ground acceleration (PGA) for return periods of 2,475, 975, and 475 years. The results are compared with seismic hazard levels from previous PSHA studies using area sources. The effect of the fault is apparent towards the northeastern side of UAE since the increase in the slip rate of the Dibba fault compared to the rest of the faults contributed to the increase in the seismic hazard in the vicinity of the fault. Contour maps for the SAs at 0.2 and 1.0 s and PGA are developed to be used for the seismic hazard design in the UAE. The largest seismic hazard is estimated in the northeastern borders of UAE at the coastal area of Ras-Al Khaimah with PGA 0.22g for a return period of 2,475 years.
Quantification of cyclin D1 and D2 proteins in multiple myeloma identifies different expression patterns from those revealed by gene expression profiling
Authors: Cardona-Benavides Ignacio , Misiewicz-Krzeminska IRENA , Rojas Elizabeta A. , de Ramón Cristina , Sanz-Solas Antonio , Isidro Isabel , Quwaider Dalia , López-Guerrero Aida , Cuadrado Myriam , Calasanz Maria José , Rosiñol Laura , Martínez-López Joaquin , Miguel Jesus San , Manteca Maria Victoria Mateos , Corchete Luis Antonio , GUTIERREZ NORMA
Published: March 2023

Upregulation of a cyclin D gene determined by expression microarrays is an almost universal event in MM, but this finding has not been properly confirmed at the protein level. For this reason, we carried out a quantitative analysis of cyclin D proteins using a capillary electrophoresis nanoimmunoassay in newly diagnosed MM patients.
Exclusive expression of cyclin D1 and D2 proteins was detected in 54/165 (33%) and 30/165 (18%) of the MM patients, respectively. It is of note that cyclin D1 or D2 proteins were undetectable in 41% of the samples. High levels of cyclin D1 protein were strongly associated with the presence of t(11;14) or 11q gains. However, cyclin D2 protein was detected in all the cases bearing t(14;16), but in only 24% of patients with t(4;14). The presence of cyclin D2 was associated with shorter OS (HR=2.14, p=0.017), although patients overexpressing cyclin D2, but without 1q gains, had a favorable prognosis.
In conclusion, although one of the cyclins D is overexpressed at the mRNA level in almost all MM patients, in approximately half of the patients this does not translate into detectable protein. This implies that cyclins D could not play an oncogenic role in a proportion of patients with MM.
A multi-criteria decision-making is the ANP network analysis process for identification relief centers in urban areas: A case of study Tabriz city, Iran
Authors: Ghalehteimouri Kamran Jafarpour , Khaliji Mohammad Ali
Published: March 2023

Cities' growing populations and densities create an atmosphere that is conducive to changes in their structure. Accordingly, factors that increase the number of vulnerable groups, such as women, children, the elderly, and people with disabilities, include urban population growth, high-rise buildings, apartment living, industrial concentration, the growth of impoverished neighbourhoods, and informal settlements. Given the earthquake-prone regions of northwest Iran and the frequency of earthquakes in this region in recent years, it is essential to comprehend the characteristics of the natural environment in order to determine the optimal place for the development of urban structures and relief centres. The purpose of this study is to locate potential sites for the development of temporary housing and relief operations. This study, whose methodology is survey and analysis using the ANP model, has discussed the location of places for the establishment of rescue centres and temporary housing for the population according to the physical, environmental, and social criteria, which immediately after the earthquake, the possibility of rescuing the lives of those who witnessed the accident, and the creation of a temporary shelter. The findings indicate that west of Tabriz is the optimum place for the construction of rescue facilities and temporary people settlement based on the distance from natural crisis elements.
Effects of a Collaborative Gamification on Learning and Engagement of Children with Autism
Authors: Silva Laíza , Isotani Seiji , Toda Armando , Challco Geiser , Elias Nassim
Published: March 2023

Gamification, i.e., the use of game elements in non-game contexts, is an effective tool to help children learn using educational technologies. When properly utilized together with pedagogical approaches that foster students' interactions with learning materials, gamification has consistently been shown to increase students' participation, motivation, engagement, and learning gains. Nevertheless, when we consider children with autism, there is little evidence about the benefits of gamification for learning. In addition, to develop gamified educational technologies for this public, it is necessary to know a method of psychology, and few practitioners in this area have this knowledge. A collaborative design in which the collaborators come from different knowledge backgrounds, known as co-design, may deal with this issue. We conducted a single-subject design experiment to assess the effect of a gamified co-design. In this co-design, one practitioner in game design and two psychology experts in autism elaborated a prototype of an application, and DTT (Discrete Trial Training) approach was used to support the learning activities. DTT is a psychology method that demonstrated effectivity in children with autism, and it is based on the use of response to stimuli through repetition and reinforcement. Findings indicated that the developed prototype fosters correct answers, reduces undesired behaviors, follows ABA (Applied Behavior Analysis) skills, and presents positive behaviors. We concluded that co-design is a promising approach to be used in gamification in a context that requires expert knowledge, as ASD (Autism Spectrum Disorder).
Infant-type hemispheric glioma occurring at the cervicomedullary region in a 5-month-old infant: A case report with a special emphasis on molecular classification
Authors: Yamada Erika , Muroi Ai , Suzuki Ryoko , Kino Hiroyoshi , Sakamoto Noriaki , Tsurubuchi Takao , Ishikawa Eiichi
Published: March 2023

High-grade gliomas in infancy are uncommon and have different clinical and molecular characteristics of those in adults. Recently, advances in molecular diagnostics have made progress in determining treatment strategies; however, the robust treatment has not yet been elucidated. We herein present a case of glioma occurring at the cervicomedullary region in a 5-month-old infant who developed left upper limb weakness and torticollis at 3 months of age. Magnetic resonance imaging revealed T2 hyperintensity from the medulla oblongata to the upper cervical cord. She underwent biopsy for the lesion and pathological examination findings confirmed the presence of a high-grade astrocytoma with IDH wildtype-, H3K27M wildtype-, BRAF wildtype-, and ETV-NTRK3 fusion-positivity. Postoperatively, she underwent chemoradiotherapy, but she had marked tumor growth during the treatment. According to the new World Health Organization classification, the patient’s tumor is an infantile “hemispheric” glioma. Although the characteristics and prognosis of NTRK-fused glioma are not fully understood, it is noteworthy that these tumors commonly occur in the brainstem. Further studies are needed to determine the prognosis of each tumor type and its sensitivity to treatment. This information will help in the reclassification of the tumors and identification of the precise treatment of this rare type of tumor.
Affordable panel of techniques for prediction of molecular classification of a series of medulloblastomas in a reference pediatric hospital in Colombia
Authors: Salazar Linda Paola Bárcenas , Gaviria-Delgado Diana , Guerrero María Fernanda , Osorio Luz Karime , Alvarez Rosario , Cabrera Edgar , Olaya Natalia
Published: March 2023

Molecular classification of medulloblastomas helps in improving risk-stratification. However, application in routine practice remains a challenge in low and middle-income countries. In Colombia, children often have delayed and uncomplete diagnosis. We underwent a retrospective analysis of 49 cases of medulloblastoma treated between 2009 and 2017 in a reference pediatric hospital in Bogotá, Colombia. This manuscript reports the use of a immunohistochemical plus PCR panel to distinguish SHH, WNT, and non-SHH/WNT tumors and details their clinical and pathological features. We analyzed Beta-catenin, p75NTR, PIGU, OTX2, YAP1 and P53 by immunohistochemistry and performed PCR for C-myc and N-myc amplification. We found a high percentage of SHH tumors and a high prevalence of desmoplastic-nodular tumors in our series. The male: female ratio was different from reported in other latitudes. We believed it would be important to complement these results by new generation sequencing and the gold standard in the medulloblastoma diagnosis, the methylation analysis. However, the panel we propose is useful to predict the molecular group. This is the first medulloblastoma case series in Colombia.
Novel Prognostic Model of Ferroptosis in Colon adenocarcinoma
Authors: yu qian , pang jianyu , Chen Yongzhi , qi qi , Tang Yuheng , Sheng Miaomiao , tang Wenru
Published: March 2023

One of the most frequent gastrointestinal cancers in the world is colorectal cancer (Coad). Iron degradation might be caused by an imbalance in intracellular iron metabolism. The modification of the immune milieu and the success of tumor immunotherapy are both significantly impacted by hypertrophy. The onset and progression of cancer are both impacted by the imbalance of iron metabolism. My study is now heavily focused on how to use ferrite in conjunction with immunotherapy to prevent the growth of colon adenocarcinoma.Unknown potential indicators of iron metabolism and immunological control in COAD still exist. We used LASSO regression to model the best iron death prognosis in COAD patients, and survival analysis and ROC curves were used to assess the predictive value in the training cohort and external validation cohort. We carried out pathway analysis and immune infiltration to confirm the efficacy of our model and to identify the prognostic indicators that we are interested in. Additionally, we demonstrated the intermolecular interactions between the prognostic molecule and hundred of other chemicals using batch molecular docking. In this manner, useful therapeutic compounds can be discovered.
Different emotion regulation strategies mediate the relations of corresponding connections within the default-mode network to sleep quality
Authors: Chen Yang , Zhang Li , Yin Huazhan
Published: March 2023

Despite a long history of interest in the relation of emotion regulation (ER) to sleep quality, how ER is linked with sleep quality at the neural level is still poorly understood. Accordingly, we adopted the resting-state functional connectivity (rsFC) analysis to identify the neural bases linking ER with sleep quality. 183 young adults (51.7% females,Mage= 22.16) were guided to undergo the MRI scans and then complete the Pittsburgh Sleep Quality Index (PSQI) and the emotion regulation Questionnaire (ERQ) formed by two dimensions: cognitive reappraisal and expressive suppression. Results found that ER mediated the association between functional connectivity within intrinsic default-mode network (DMN) and sleep quality. Specifically, rsFC analysis showed that cognitive reappraisal was positively correlated with rsFC within DMN, including left superior temporal gyrus (lSTG)-left lateral occipital cortex (lLOC), lSTG-left anterior cingulate gyrus (lACG), right lateral occipital cortex (rLOC)-left middle frontal gyrus (lMFG), and rLOC-lSTG. Further mediation analysis indicated a mediated role of cognitive reappraisal in the link between the four connectivity and sleep quality. In addition, expressive suppression was positively correlated with rsFC within DMN, including left precuneus cortex (lPrcu)-right Temporal Pole (rTP) and lPrcu- lSTG. Further mediation analysis indicated a mediated role of expressive suppression in the link between the two connectivity and sleep quality. Overall, this finding supports the process model of ER, in that the effects of reappraisal and suppression have varying neural circuits that impact that strategy’s effect on sleep quality.
Effect of acupuncture treatment on clinical outcomes for cervical disc herniation after minimally invasive surgery: a comparative study
Authors: Li Shun , Hu Jiaqi , Wan Quan , Ji Zhongwei , Zhang Nannan , Zhu Tingli , Ru Bin , Wang Wanchun
Published: March 2023

Purpose: Although percutaneous minimally invasive techniques have been gradually applied to the surgical treatment of cervical disc herniation (CDH), some patients still experience adverse outcomes. The aim of this study was to explore the effect of acupuncture treatment for CDH patients after minimally invasive surgery (MIS).
Methods: We retrospectively reviewed patients with CDH admitted to our department between January 1, 2019 and December 31, 2020. Visual analog scale (VAS), neck disability index (NDI), and the modified MacNab criteria were used to assess pain, function, and clinical outcomes, respectively. Characteristics between patients with acupuncture treatment and those without acupuncture treatment were compared. Logistic regression analysis was performed to investigate the effect of acupuncture treatment on clinical outcomes.
Results: 211 patients were incorporated in the cohort with 102 (48.3%) receiving acupuncture treatment. Patients with acupuncture had a lower postoperative VAS and NDI at one month, six months, and one year (all P < 0.001) after surgery. In addition, acupuncture treatment was associated with lower modified MacNab criteria score at six months and one year (both P < 0.001). Multivariate logistic regression analysis showed that acupuncture (P < 0.001, OR 9.282, 95% CI 3.469-24.836) was an independent factor for good outcomes at one year.
Conclusions: Acupuncture treatment had beneficial effects on relieving pain and improving function in CDH patients after MIS, and was a significant and independent factor for good outcomes at one year after surgery. Acupuncture could be an effective adjunct therapy for CDH patients after MIS.
Complexity Analysis of an Interior-point Algorithm for Cqp Based on a New Parametric Kernel Function
Authors: CHALEKH RANDA , DJEFFAL EL AMIR
Published: March 2023

In this paper, we present a primal-dual interior-point algorithm for convex quadratic programming problem based on a new parametric kernel function with an hiperbolic–logarithmic barrier term. Using the proposed kernel function we show some basic properties that are essential to study the complexity analysis of the correspondent algorithm which we find it coincides with the best know iteration bounds for large-update method, namely, O (√ n log n log n/ε) by a special choice of the parameter p > 1.
Thermo-dynamical random Brownian motion in a slip flow of thermophoretic fluid over a wedge under the influence of variable viscosity and conductivity
Authors: Sreedhar M. , Raju C. S.K. , Khan M. Ijaz , ElDin Sayed M.
Published: March 2023

The article exhibited the impact of variable fluid possessions (temperature dependent viscosity) on nanofluid over a wedge in the presence of heat generation and absorption. We also incorporated the magnetic field, Buogirnio model and nonlinear chemical reaction in this study. It is accepted to take viscosity and thermal conductivity as a reverse capacity and straight capacity of temperature, separately. The governing physical partial differential system (PDE) is transformed into ordinary differential equations (ODEs) and then the subsequent nonlinear ordinary differential conditions are measured numerically utilizing the fourth order of the Runge-Kutta technique jointly with the shooting method. The effect of appropriate parameters concerning the stream capacity has been talked about through charts and tables, together with the necessary disputations/discussion. The friction between the particles is higher in  β= 1/6 compared to β= 0. This help us to conclude that, for higher friction we can use the β= 1/6 case. The heat and mass transmission rate is very low in β= 0 case compared to β= 1/6 case. So, we can conclude that the β=0case useful in cooling and more concentration transferred systems.
Structural characterization of a new amino acid derivatives, Maillard Reaction product of red ginseng and potential protective activity against cisplatin-evoked intestinal injury
Authors: Liu Wei , Zheng Yi-nan , Jiang Shuang , Ren Shen , Tang Shan , Zhang Jing , Wang Zi , Li Wei
Published: March 2023

Based on the Maillard reaction principle of red ginseng (Panax ginsengC.A. Meyer), this study innovatively synthesized a new amino acid derivative by combining arginine with lactose through simulated synthesis, and was separated and purified through repeated silica gel and polyacrylamide gel (Bio-gel P-II) column chromatography. The purity of the product was determined to be 99.86% and its molecular weight was determined to be 497.3612 (negative ion mode) by electrospray ionisation mass spectrometry (ESI-MS). The chemical structure was identified to be 1-(arginine-Nαgroup)-1-deoxy-4-O-(α-D-galactopyranosyl)-D-fructose, named Argininyl-fructosyl-galactose (AFGA, C18H34N4O12). Subsequently, by establishing cisplatin-induced intestinal injury invivoand IEC-6 cell model, the results showed that pretreatment with AFGA significantly ameliorated cisplatin induced oxidative stress by reducing levels of reactive oxygen species (ROS) in IEC-6 cells (p<0.05,p<0.01), and could effectively reduce the secretion of pro-inflammatory factors in serum and the expression level of NF-κB protein in intestinal tissues (p<0.01). Meantime, AFGA also inhibited the expression of p-PI3K/p-Akt, caspase 3, 9, cytochrome C and Bax protein intestinal tissue in mice (p<0.01), and promoted the expression of Bcl-2 protein (p<0.01). Importantly, the molecular docking results of AFGA also suggested a better binding ability with the above-mentioned related target proteins, and further revealed AFGA as a potential multifunctional therapeutic agent with clear protective effect against cisplatin-induced intestinal injury.
Biomechanical study of minimally invasive correction of hallux valgus fixation with absorbable screws: A finite element analysis
Authors: Xu Can , Liu Hua , Li Mingqing , Li Hui , Pan Chun’ang
Published: March 2023

Background Absorbable screws have been applied in clinical practice for the treatment of minimally invasive hallux valgus, but most of the available publications are the results of clinical follow-up, lacking the related biomechanical studies. The aim of this study was to evaluate mechanical responses and stabilities of absorbable screws fixation after the distal metatarsal osteotomy in hallux valgus treatment. Methods In this study, the finite element method was used to construct models of hallux valgus fixation with hallux valgus angles of 30° and 40° using one or two 2.7mm and 4.5mm absorbable screws after osteotomy. Then, the stress of the materials in the bone, the anti-rotation performance, and the inter-fragmentary strain (IFS) results were analyzed by finite element analysis. Results The stress results for the two fixing methods with hallux valgus angles of 30° and 40° under the two working conditions are within the safe range under all conditions. It was also found that the screws had excellent anti-rotation performance whether the osteotomy fragment was fixed with two 2.7mm or one 4.5mm absorbable screws. All the results of inter-fragmentary strain are in the range between 0.9% and 11% which is suitable for bone healing. Conclusions The results indicate that using two 2.7mm screws or one 4.5mm screw to fix the first metatarsal minimally invasive osteotomy can both achieve satisfactory mechanical effect. There was not much difference in the simulation effect between the two fixation methods, and either method can be selected indiscriminatingly in clinical application.
Novel Carbon Nanozymes with Enhanced Phosphatase–like Catalytic Activity for Antimicrobial Applications
Authors: Nurtay Lazzat , Benassi Enrico , Nazir Faisal , Dastan Dana , Utupova Assem , Dautov Adilet , Dukenbayev Kanat , Xie Yingqiu , Pham Tri T. , Fan Haiyan
Published: March 2023

In this work, Sulfur and Nitrogen co–doped carbon nanoparticles (SN–CNPs) were synthesized by hydrothermal method using the dried beet powder as the carbon source. TEM and AFM images indicated that these SN–CNPs form a round-shape ball with an approximate diameter of 50 nm. The presence of Sulfur and Nitrogen in these carbon-based nanoparticles was confirmed by FTIR and XPS analyses. These SN–CNPs were found to have strong phosphatase–like enzymatic activity. The enzymatic behavior of SN–CNPs follows the Michaelis–Menten mechanism with greater vmax and much lower Km values compared to alkaline phosphatase. Their antimicrobial properties were tested on E. coli and L. lactis, and values of MIC were identified as 47-µg mL–1 and 188-µg mL–1, respectively. SEM and AFM images of fixed and live E. coli cells showed that SN–CNPs strongly interacted with the outer membranes of bacterial cells, which greatly increased the cell surface roughness. The chemical interaction between SN–CNPs and phospholipid modeled using quantum mechanical calculations further support our hypothesis that the phosphatase and antimicrobial properties of SN–CNPs are due to the thiol group on the SN–CNPs, which is a mimic of the cysteine–based protein phosphatase. The present work is the first to report carbon–based nanoparticles with phosphatase activity and propose a phosphatase natured antimicrobial mechanism. This novel class of carbon nanozymes has the potential to be used for effective catalytic and antibacterial applications.
On the interfacial deformations and thermal characteristics exhibiting self-similar behavior under the action of a line heat source
Authors: Shahdhaar Mohammad Autif , Srivast Atul , Singh Suneet
Published: March 2023

Interfacial dynamics resulting from a heating source located near the interface play a crucial role in dictating the heat and momentum transport in the near-interface region. This paper aims towards simultaneous characterization of interfacial deformation and thermal behavior under the action of a line heating source placed below the interface. Experiments have been conducted on aqueous glycerol with a heating wire at different power inputs and depths from the interface. The interfacial deformations are mapped and quantified by employing moon glade background oriented schlieren, which offers real-time, non-intrusive whole field measurements based on the deflection of light rays from liquid interface. Infrared thermography is used to measure transient interfacial temperature variations. Results show that the interface exhibits a convex-shaped deformation under the influence of the heating wire for all cases of heating power and depth. The maximum interface temperature coincides with the peak interfacial deformation. However, the region of thermal influence is smaller compared to the deformed region. Non-dimensionalization of transient interface deformation and temperature profiles establishes the underlying similarity of the phenomenon as non-dimensional interface perturbation profiles overlap for all cases of height and heating power. These characteristics are also observed for normalized temperature profiles at different wire depths.