bluuebunny/crossref_metadata_2025 huggingface dataset:
Author Correction: Non-professional phagocytosis: a general feature of normal tissue cells
Authors: Seeberg Jacob C. , Loibl Monika , Moser Fabian , Schwegler Manuela , Büttner-Herold Maike , Daniel Christoph , Engel Felix B. , Hartmann Arndt , Schlötzer-Schrehardt Ursula , Goppelt-Struebe Margarete , Schellerer Vera , Naschberger Elisabeth , Ganzleben Ingo , Heinzerling Lucie , Fietkau Rainer , Distel Luitpold V.
Published: June 2020

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
CX3CL1 homo-oligomerization drives cell-to-cell adherence
Authors: Ostuni Mariano A. , Hermand Patricia , Saindoy Emeline , Guillou Noëlline , Guellec Julie , Coens Audrey , Hattab Claude , Desuzinges-Mandon Elodie , Jawhari Anass , Iatmanen-Harbi Soria , Lequin Olivier , Fuchs Patrick , Lacapere Jean-Jacques , Combadière Christophe , Pincet Frédéric , Deterre Philippe
Published: June 2020

During inflammatory response, blood leukocytes adhere to the endothelium. This process involves numerous adhesion molecules, including a transmembrane chemokine, CX3CL1, which behaves as a molecular cluster. How this cluster assembles and whether this association has a functional role remain unknown. The analysis of CX3CL1 clusters using native electrophoresis and single molecule fluorescence kinetics shows that CX3CL1 is a homo-oligomer of 3 to 7 monomers. Fluorescence recovery after photobleaching assays reveal that the CX3CL1-transmembrane domain peptide self-associates in both cellular and acellular lipid environments, while its random counterpart (i.e. peptide with the same residues in a different order) does not. This strongly indicates that CX3CL1 oligomerization is driven by its intrinsic properties. According to the molecular modeling, CX3CL1 does not associate in compact bundles but rather with monomers linearly assembled side by side. Finally, the CX3CL1 transmembrane peptide inhibits both the CX3CL1 oligomerization and the adhesive function, while its random counterpart does not. This demonstrates that CX3CL1 oligomerization is mandatory for its adhesive potency. Our results provide a new direction to control CX3CL1-dependent cellular adherence in key immune processes.
Removal mechanism of Pb(II) by Penicillium polonicum: immobilization, adsorption, and bioaccumulation
Authors: Xu Xiyang , Hao Ruixia , Xu Hui , Lu Anhuai
Published: June 2020

Currently, lead (Pb) has become a severe environmental pollutant and fungi hold a promising potential for the remediation of Pb-containing wastewater. The present study showed that Penicillium polonicum was able to tolerate 4 mmol/L Pb(II), and remove 90.3% of them in 12 days through three mechanisms: extracellular immobilization, cell wall adsorption, and intracellular bioaccumulation. In this paper. the three mechanisms were studied by Raman, X-ray diffraction analysis (XRD), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR) and transmission electron microscopy (TEM). The results indicated that Pb(II) was immobilized as lead oxalate outside the fungal cell, bound with phosphate, nitro, halide, hydroxyl, amino, and carboxyl groups on the cell wall, precipitated as pyromorphite [Pb5(PO4)3Cl] on the cell wall, and reduced to Pb(0) inside the cell. These combined results provide a basis for additionally understanding the mechanisms of Pb(II) removal by P. polonicum and developing remediation strategies using this fungus for lead-polluted water.
Extended Bose-Hubbard Model with Cavity-Mediated Infinite-Range Interactions at Finite Temperatures
Authors: Chen Huang-Jie , Yu Yan-Qiang , Zheng Dong-Chen , Liao Renyuan
Published: June 2020

We consider the finite-temperature properties of the extended Bose-Hubbard model realized recently in an ETH experiment [Nature 532, 476 (2016)]. Competing short- and global-range interactions accommodate fascinating collective phenomena. We formulate a self-consistent mean-field theory to describe the behaviors of the system at finite temperatures. At a fixed chemical potential, we map out the distributions of the superfluid order parameters and number densities with respect to the temperatures. For a charge density wave, we find that the global-range interaction enhances the charge order by increasing the transition temperature at which the charge order melts out, while for a supersolid phase, we find that the disappearance of the charge order and the superfluid order occurs at different temperature. At a fixed number-density filling factor, we extract the temperature dependence of the thermodynamic functions such as internal energy, specific heat and entropy. Across the superfluid phase transition, the specific heat has a discontinuous jump.
Frontoparietal structural properties mediate adult life span differences in executive function
Authors: Yao Zai-Fu , Yang Meng-Heng , Hwang Kai , Hsieh Shulan
Published: June 2020

Executive function (EF) refers to a set of cognitive functions that support goal-directed behaviors. Recent findings have suggested that the frontoparietal network (FPN) subserves neural processes that are related to EF. However, the FPN structural and functional network properties that mediate age-related differences in EF components remain unclear. To this end, we used three experimental tasks to test the component processes of EF based on Miyake and Friedman’s model: one common EF component process (incorporating inhibition, shifting, and updating) and two specific EF component processes (shifting and updating). We recruited 126 healthy participants (65 females; 20 to 78 years old) who underwent both structural and functional MRI scanning. We tested a mediation path model of three structural and functional properties of the FPN (i.e., gray matter volume, white matter fractional anisotropy, and intra/internetwork functional connectivity) as mediators of age-related differences in the three EF components. The results indicated that age-related common EF component differences are mediated by regional gray matter volume changes in both hemispheres of the frontal lobe, which suggests that structural changes in the frontal lobe may have an indirect influence on age-related general elements of EF. These findings suggest that the FPN mediates age-related differences in specific components of EF.
Author Correction: Characterization of Hailey-Hailey Disease-mutants in presence and absence of wild type SPCA1 using Saccharomyces cerevisiae as model organism
Authors: Muncanovic Daniel , Justesen Mette Heberg , Preisler Sarah Spruce , Pedersen Per Amstrup
Published: June 2020

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
WilsonGen a comprehensive clinically annotated genomic variant resource for Wilson’s Disease
Authors: Kumar Mukesh , Gaharwar Utkarsh , Paul Sangita , Poojary Mukta , Pandhare Kavita , Scaria Vinod , BK Binukumar
Published: June 2020

Wilson disease (WD) is one of the most prevalent genetic diseases with an estimated global carrier frequency of 1 in 90 and a prevalence of 1 in 30,000. The disease owes its genesis to Kinnier Wilson who described the disease, and is caused by accumulation of Copper (Cu) in various organs including the liver, central nervous system, cornea, kidney, joints and cardiac muscle which contribute to the characteristic clinical features of WD. A number of studies have reported genetic variants in the ATP7B gene from diverse ethnic and geographical origins. The recent advent of next-generation sequencing approaches has also enabled the discovery of a large number of novel variants in the gene associated with the disease. Previous attempts have been made to compile the knowledgebase and spectrum of genetic variants from across the multitude of publications, but have been limited by the utility due to the significant differences in approaches used to qualify pathogenicity of variants in each of the publications. The recent formulation of guidelines and algorithms for assessment of the pathogenicity of variants jointly put forward by the American College of Medical Genetics and the Association of Molecular Pathologists (ACMG &) has provided a framework for evidence based and systematic assessment of pathogenicity of variants. In this paper, we describe a comprehensive resource of genetic variants in ATP7B gene manually curated from literature and data resources and systematically annotated using the ACMG & AMP guidelines for assessing pathogenicity. The resource therefore serves as a central point for clinicians and geneticists working on WD and to the best of our knowledge is the most comprehensive and only clinically annotated resource for WD. The resource is available at URL http://clingen.igib.res.in/WilsonGen/. We compiled a total of 3662 genetic variants from publications and databases associated with WD. Of these variants compiled, a total of 1458 were found to be unique entries. This is the largest WD database comprising 656 pathogenic/likely pathogenic variants reported classified according to ACMG & AMP guidelines. We also mapped all the pathogenic variants corresponding to ATP7B protein from literature and other databases. In addition, geographical origin and distribution of ATP7B pathogenic variants reported are also mapped in the database.
Author Correction: The role of sentrin-specific protease 2 substrate recognition in TGF-β-induced tumorigenesis
Authors: Chang Che-Chang , Huang Yen-Sung , Lin Ying-Mei , Lin Chia-Ju , Jeng Jen-Chong , Liu Shin-Mei , Ho Tsai-Ling , Chang Ruei-Ting , Changou Chun A. , Ho Chun-Chen , Shih Hsiu-Ming
Published: June 2020

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Fe3+ detection, bioimaging, and patterning based on bright blue-fluorescent N-doped carbon dots
Authors: Li Lin , Shi Lihong , Jia Jing , Chang Dan , Dong Chuan , Shuang Shaomin
Published: June 2020

The bright blue fluorescent N-doped carbon dots (N-CDs) was successfully fabricated by one-step hydrothermal treatment of astragalus and was exploited for cellular imaging and patterning.
Metal–organic complex-based chemodynamic therapy agents for cancer therapy
Authors: Hwang Eunbin , Jung Hyo Sung
Published: June 2020

This feature article summarizes the recent progress in the study of chemodynamic therapy agents based on metal–organic complexes.
Stabilizing the crystal structures of NaFePO4 with Li substitutions
Authors: Wang Renhai , Wu Shunqing , Zhang Feng , Zhao Xin , Lin Zijing , Wang Cai-Zhuang , Ho Kai-Ming
Published: June 2020

We build a crystal structure database for NaFePO4 by replace Li with Na in LiFePO4, and stabilize the olivine type of NaFePO4 with Li substitutions.
DFT and MD simulation supplemented experiments for isotopic fractionation of zinc compounds using a macrocyclic crown ether appended polymeric resin
Authors: Singha Deb A. K. , Sahu P. , Boda A. , Ali Sk. M. , Shenoy K. T. , Upadhyay D.
Published: June 2020

Isotope effect is a quantum mechanical phenomenon and thus poses a challenge for the separation of isotopes of an element of interest, especially for heavy elements.
Building a robust 3D Ca-MOF by a new square Ca4O SBU for purification of natural gas
Authors: Hu Falu , Di Zhengyi , Wu Mingyan , Li Jing
Published: June 2020

For the first time, a new square Ca4O SBU is introduced into a 3D Ca-MOF, ([MeNH2]2[Ca4O(MTB)2(EtOH)4])·(solvent)n (1), to generate a structure with (4,8)-connected flu-topology, which shows good selectivity of CO2, C2 and C3 hydrocarbons over CH4.
Additive-free spin coating of tin oxide thin films: synthesis, characterization and evaluation of tin β-ketoiminates as a new precursor class for solution deposition processes
Authors: Huster Niklas , Zanders David , Karle Sarah , Rogalla Detlef , Devi Anjana
Published: June 2020

A series of tin(ii) β-ketoiminate complexes was synthesized and evaluated for the deposition of SnO2 films via additive free spin coating.
Polypyrrole coated δ-MnO2 nanosheet arrays as a highly stable lithium-ion-storage anode
Authors: Sui Yiming , Liu Chaofeng , Zou Peichao , Zhan Houchao , Cui Yuanzheng , Yang Cheng , Cao Guozhong
Published: June 2020

Manganese dioxide (MnO2) with a conversion mechanism is regarded as a promising anode material for lithium-ion batteries (LIBs) owing to its high theoretical capacity (∼1223 mA h g−1) and environmental benignity as well as low cost.
Variable-height channels for microparticle characterization and display
Authors: Mena Sarah E. , de Beer Martin P. , McCormick Joseph , Habibi Nahal , Lahann Joerg , Burns Mark A.
Published: June 2020

A unique glass etching process creates variable height channels capable of separating particles or cells by size or deformability.
Insights into N, P, S multi-doped Mo2C/C composites as highly efficient hydrogen evolution reaction catalysts
Authors: Xu Jieyu , Ge Lin , Zhou Yajun , Jiang Guangyu , Li Liang , Li Yunheng , Li Yongsheng
Published: June 2020

N, P, S multi-doped Mo2C/C exhibits highly efficient HER performance, derived from stronger synergistic N, P, S multi-doping coupling effects.
Ruthenocycles of benzothiazolyl and pyridyl hydrazones with ancillary PAHs: synthesis, structure, electrochemistry and antimicrobial activity
Authors: Dinda Soumitra , Sultana Tamanna , Sultana Suhana , Patra Sarat Chandra , Mitra Arup Kumar , Roy Subhadip , Pramanik Kausikisankar , Ganguly Sanjib
Published: June 2020

The antimicrobial activity of ruthenocycles of pyridyl and benzothiazolyl hydrazones has been investigated. The study established that such activity is comparatively higher for the complex containing benzothiazolyl hydrazone.
The simple-preparation of Cu–Ni/CuO–NiO using solution plasma for application in a glucose enzyme-free sensor
Authors: Yang Bingqian , Qiao Jingyuan , Yu Yawei , Yuan Lefan , Hu Xiulan
Published: June 2020

The design of composite catalysts with two metals and their oxides for the detection of glucose is a particularly novel method to couple together the advantages of different kinds of metals.
Morphological transformation of ultrasonically obtained nanofibers during living self-assembly
Authors: Zhang Liangkai , Gong Yanjun , Wang Tao , Xiao Jianhong , Pang Yiping , Hu Qiongzheng , Yu Li
Published: June 2020

The nanofibers are obtained by ionic self-assembly and living self-assembly.
Water dissolvable MoS2 quantum dots/PVA film as an active material for destructible memristors
Authors: Koduvayur Ganeshan Sankalp , Selamneni Venkatarao , Sahatiya Parikshit
Published: June 2020

This report demonstrates the fabrication of a flexible, water-soluble MoS2 QDs/PVA (polyvinyl alcohol) film sandwiched between Cu electrodes as a resistive memory.
Synthesis of CoS2/SnO2@MoS2 nanocube heterostructures for achieving enhanced electrocatalytic hydrogen evolution in acidic media
Authors: He Qian , Huang Shaowei , Liu Mengying , Li Pan , Sun Wen , Hou Linxi
Published: June 2020

The heterostructures of CoS2/SnO2@MoS2 (CSM1) nanocubes have been synthesized as efficient electrocatalysts for the HER in acidic media.
Correlating the size and cation inversion factor in context of magnetic and optical behavior of CoFe2O4 nanoparticles
Authors: Singh Jitendra Pal , Park Jae Yeon , Singh Varsha , Kim So Hee , Lim Weon Cheol , Kumar Hemaunt , Kim Y. H. , Lee Sangsul , Chae Keun Hwa
Published: June 2020

Herein, the size dependent behavior of cobalt ferrite nanoparticles was investigated using synchrotron radiation based techniques.
Glycolytic and lipid oxidative metabolic programs are essential for freshly-isolated regulatory T cells in mice with sepsis
Authors: Zhu Xiaomei , Ji WenQing , Guo Shubin , Zhu Di , Yang Yue , Liu Xin
Published: June 2020

Freshly-isolated Treg cells showed metabolic reprogramming in mice with sepsis, mainly manifested by increased glycolysis and fatty acid oxidation pathways.
Development of glycine-copper(ii) hydroxide nanoparticles with improved biosafety for sustainable plant disease management
Authors: Dong Hongqiang , Xiong Renci , Liang You , Tang Gang , Yang Jiale , Tang Jingyue , Niu Junfan , Gao Yunhao , Zhou Zhiyuan , Cao Yongsong
Published: June 2020

The prepared Gly-Cu(OH)2 NPs could significantly reduce the severity of bacterial black rot and had no effect on phytotoxicity.
Drastic power factor improvement by Te doping of rare earth-free CoSb3-skutterudite thin films
Authors: Bourgès Cédric , Sato Naoki , Baba Takahiro , Baba Tetsuya , Ohkubo Isao , Tsujii Naohito , Mori Takao
Published: June 2020

In the present study, we have focused on the elaboration of control of Te-doped CoSb3thin films by RF magnetron sputtering which is an attractive technique for industrial development of thermoelectric (TE) thin films.
One-pot synthesis of symmetric imidazolium ionic liquids N,N-disubstituted with long alkyl chains
Authors: Damilano Giacomo , Kalebić Demian , Binnemans Koen , Dehaen Wim
Published: June 2020

The modified Debus–Radziszewski reaction was used as a one-pot on-water reaction to allow a greener synthesis of long-chain 1,3-dialkylimidazolium acetate ionic liquids in high yield from long-chain linear amines.
Fabrication of a reversible thermochromism based temperature sensor using an organic–inorganic composite system
Authors: Mehta Sunita , Kushwaha Ashok , Kisannagar Ravinder Reddy , Gupta Dipti
Published: June 2020

A simple, inexpensive and reusable temperature sensor based on screen printed flexible thin films.
Synthesis, local structure and optical property studies of α-SnS microrods by synchrotron X-ray pair distribution function and micro-Raman shift
Authors: Gawai U. P. , Gaikwad D. K. , Patil S. L. , Pandey K. K. , Lalla N. P. , Dole B. N.
Published: June 2020

The PDF refinement shows layer structure of SnS-A with two distinct bond lengths, one nearly parallel to the ‘a’ axis and another perpendicular to the ‘a’ axis, it corresponds to bond lengths of 2.62528 (38) Å and 2.66204 (03) Å.
One-step electrosynthesis of visible light responsive double-walled alloy titanium dioxide nanotube arrays for use in photocatalytic degradation of dibutyl phthalate
Authors: Wang Yuan , Zhang Xueke , You Suzhen , Hu Yun
Published: June 2020

The double-walled alloy titanium dioxide nanotube arrays (DW-ATNTAs) with special porous inner walls exhibit superior photocatalytic activity under visible light for rich porous inner wall provided sufficient vacancy for adsorption and active sites.
Role of DZIP1–CBY–FAM92 transition zone complex in the basal body to membrane attachment and ciliary budding
Authors: Lapart Jean-André , Billon Amélie , Duteyrat Jean-Luc , Thomas Joëlle , Durand Bénédicte
Published: June 2020

Cilia play important signaling or motile functions in various organisms. In Human, cilia dysfunctions are responsible for a wide range of diseases, called ciliopathies. Cilia assembly is a tightly controlled process, which starts with the conversion of the centriole into a basal body, leading to the formation of the ciliary bud that protrudes inside a ciliary vesicle and/or ultimately at the cell surface. Ciliary bud formation is associated with the assembly of the transition zone (TZ), a complex architecture of proteins of the ciliary base which plays critical functions in gating proteins in and out of the ciliary compartment. Many proteins are involved in the assembly of the TZ, which shows structural and functional variations in different cell types or organisms. In this review, we discuss how a particular complex, composed of members of the DZIP1, CBY and FAM92 families of proteins, is required for the initial stages of cilia assembly leading to ciliary bud formation and how their functional hierarchy contributes to TZ assembly. Moreover, we summarize how evidences in Drosophila reveal functional differences of the DZIP1–CBY–FAM92 complex in the different ciliated tissues of this organism. Whereas it is essential for proper TZ assembly in the two types of ciliated tissues, it is involved in stable anchoring of basal bodies to the plasma membrane in male germ cells. Overall, the DZIP1–CBY–FAM92 complex reveals a molecular assembly pathway required for the initial stages of ciliary bud formation and that is conserved from Drosophila to Human.
How Is Quality of Life Assessed in People With Dementia? A Systematic Literature Review and a Primer for Speech-Language Pathologists
Authors: Heuer Sabine , Willer Rebecca
Published: June 2020

Purpose

The purpose of this study was to determine how quality of life (QoL) is measured in people with dementia involved in interventions designed to improve well-being and to explore how those measures align with principles of person-centered care.

Method

A systematic literature review was conducted utilizing PsychInfo, CINAHL, and PubMed and combinations of the search terms: “dementia,” “outcome measure,” “creative engagement,” “creative intervention,” “TimeSlips,” “art,” “quality of life,” and “well-being.” The search was limited to studies published in peer-reviewed journals that reported outcomes for people with dementia in response to a creative intervention.

Results

Across the 24 reviewed studies, 30 different outcome measures were reported including eight self-reported, nine observational, and 13 proxy-reported measures. Self-report of QoL was elicited 16 times, observational measures were reported 17 times, and proxy-reported measures were used 28 times. All measures were used with participants across the dementia severity spectrum.

Conclusion

Current clinical practice of QoL evaluation does not align well with person-centered care principles of self-determination based on the low proportion of self-report. The previously reported limitations of proxy-report have been in part confirmed with this study. Implications of the findings for speech-language pathologists are discussed.
Describing the Composition of Individualized Education Plans for Students With Traumatic Brain Injury
Authors: Harvey Judy , Farquharson Kelly , Schneider-Cline Whitney , Bush Erin , Pelatti Christina Yeager
Published: June 2020

Purpose

The purpose of this study was to explore and describe the features of Individualized Education Plans (IEPs) for a cohort of students with traumatic brain injury (TBI) to help elucidate current special education practices for students with TBI.

Method

We obtained permission from administrators of a local school district of 41,000 students in a Midwestern state to review de-identified IEP records of students verified with TBI. We examined demographic information (i.e., cause and age at time of injury), IEP services and intensity, IEP goal categories, and previous verification status.

Results

Descriptive results support that intervention services were more intense for students with TBI with greater lengths of time postinjury. Target behaviors within goals were more often related to math and reading than to the cognitive processes that govern these skills, such as attention, memory, and executive functioning. Finally, more than a third of our sample had been verified with a disability and were receiving special education services via an IEP prior to their TBI.

Conclusions

This work represents an important first step in understanding the special education services for students with TBI. Future research should explore interventions that are ecologically valid for school-based settings and are developed to address the idiosyncratic deficits of students with TBI, particularly interventions that focus on the underlying cognitive processes experienced by these students.
Highly conductive polymer nanocomposites for emerging high voltage power cable shields: experiment, simulation and applications
Authors: Huang Xingyi , Sun Boyang , Yu Chunyang , Wu Jiandong , Zhang Jun , Jiang Pingkai
Published: June 2020

High voltage power cables play a critical role in global electricity transmission and distribution. The currently used power cables cannot fulfil the green and sustainable requirement of modern society because of the thermoset nature of cable insulation and shields. This study is aimed at developing thermoplastic shields for high voltage power cable, which is one bottleneck restricting the development of environmental‐friendly cables. Using carbon black (CB) as the main conductive component and a small amount of carbon nanotubes (CNTs) or graphene as the second filler, highly conductive polypropylene based composite materials were prepared for potential shield applications. It was found that, at a fixed conductive filler loading, the replacement of a small amount CB by CNTs can significantly enhance the electrical conductivity and suppress its temperature dependence. However, when CB was replaced by graphene, only limited enhancement of electrical conductivity could be achieved and the electrical conductivity is still highly dependent on temperature. Dissipative particle dynamics simulations demonstrated that the enhanced conduction property in the CNTs‐containing composites could be understood by the shorter average distance between CB and CNTs. Finally, the coordination between the newly developed conductive composites and the environmental‐friendly thermoplastic polypropylene insulation was evaluated via high voltage direct current measurements, and the results revealed that the CNTs‐containing composites showed excellent suppression effect on the space charge injection and accumulation in the insulation. This research paved a new way for developing environmental‐friendly high voltage power cable shields.
Forecasting and optimisation for microgrid in home energy management systems
Authors: Shakir Majed , Biletskiy Yevgen
Published: June 2020

The wide proliferation of renewable energy and deregulation of power grid systems require small power utilization systems to deploy intelligent methods of adjustment to the user power demand. To accomplish this goal, the smart power demand forecasting and power consumption optimization methods and algorithms need to be developed. For this purpose, small power utilization systems can benefit from the techniques developed for the smart grid in general. The present paper is devoted to the development of a forecasting model based on the Long Short‐Term Memory (LSTM) method and an optimization model based on Genetic Algorithm (GA) adopted for the use in home energy management systems (HEMS). The present work describes a smart microgrid architecture with a focus on LSTM and GA. The experiments demonstrate that the developed algorithms generate a stable pattern of daily power demand. The use of the developed algorithms allows automated shifting of power to achieve the lowest price without sacrificing their comfort. The main contributions of the present work are the inclusion of all parts of the smart microgrid architecture (non‐invasive load identification, forecasting, optimization, renewable energy sources and storage elements) in the research proposing a fully automated control in HEMS rather than recommendation based only.
Model predictive control with constant switching frequency for four‐leg DSTATCOM using three‐dimensional space vector modulation
Authors: Kumar Alladi Pranay , Siva Kumar Ganjikunta , Sreenivasarao Dharmavarapu
Published: June 2020

In this study, model predictive control (MPC) with constant switching frequency is proposed for four‐leg distribution static compensator (FL‐DSTATCOM) to compensate the current related power quality issues. MPC techniques having many advantages compared to conventional pulse width modulation and hysteresis control techniques. In MPC, the future behaviour of the controlled variable is predicted using the model of the system and a cost function is formed using reference and predicted variable. MPC for DSTATCOM applications consider the difference between the reference and actual DSTATCOM current as a cost function and selects the switching state which minimises the cost function. However, while using MPC, the switches of DSTATCOM operate in variable switching frequency and sometimes the values are also very high. Due to this reason higher switching losses, unequal stress appear across the inverter switches and it also reduces the lifetime of the switch. Therefore, in this study, the concept of three‐dimensional space vector modulation is adopted to achieve a constant and user‐defined switching frequency MPC for FL‐DSTATCOM to conquer the limitations of conventional variable switching frequency MPC. The validation of the proposed work is achieved using simulation and experimental studies.
Frequency‐constrained unit‐commitment using analytical solutions for system frequency responses considering generator contingencies
Authors: Rabbanifar Payam , Amjady Nima
Published: June 2020

The frequency responses of a power system following a generator outage are closely related to the commitment states of generators, which describe the droop and inertial characteristics and system pre‐contingency power dispatch. This study presents a new model to estimate the transient and steady state frequency responses of two‐area power systems at any moment following the loss of an online generator. In the proposed model, the deviations of tie‐flow, area frequencies and rate of change of area frequencies as well as the extreme values of these functions and their associated time of occurrence following the outage of a generation unit are derived as modified analytical functions. A new approach is also proposed to linearise the modified extreme deviations based on pseudo‐Boolean function theorem. In addition, a frequency‐constrained unit commitment model with modified frequency‐dependent constraints incorporating primary frequency regulation reserve is presented as a mixed‐integer linear programming problem. The results indicate that the proposed method gives acceptable approximations for post‐contingency responses and can ensure power system security from frequency viewpoint.
Voltage regulation in constrained distribution networks by coordinating electric vehicle charging based on hierarchical ADMM
Authors: Zhou Xu , Zou Suli , Wang Peng , Ma Zhongjing
Published: June 2020

The charging coordination of large‐scale electric vehicles (EVs) for avoiding the voltages at some nodes to drop below feasible ranges in distribution networks, which is formulated as a class of optimisation problems with a certain class of coupled constraints, is studied. Then the alternating direction method of multipliers (ADMM) is introduced to obtain the optimal charging strategies. However, due to the non‐separable property of the objective function which includes a non‐linear term of the total charging power of EV populations, it is difficult to decentralise the update step of the charging strategy in the ADMM method. Consequently, a novel decentralised hierarchical method is proposed by further developing an iterative update of best responses of individual EVs at each iteration step of the proposed ADMM method, such that individual EVs can implement the coordination behaviours locally and simultaneously without sharing any other private information except the charging power. Furthermore, the proposed approach does not require the objective function to be continuously differentiable. The convergence and optimality of the proposed method are verified and some numerical simulations are studied to illustrate the developed results.
Erworbene immunvermittelte Thrombozytopenie in der Intensivmedizin: Ein Update über relevante Aspekte der Diagnostik und Therapie
Authors: Hidiatov Oleg , Zlamal Jan , Aidery Parwez , Bakchoul Tamam
Published: June 2020

Was ist neu?

Thrombozytopenie bei Intensivpatienten und medikamenteninduzierte Immunthrombozytopenie Aktuell sind mehr als 300 Medikamente mit der medikamenteninduzierten Immunthrombozytopenie assoziiert. Bei schwerer Thrombozytopenie kann neben dem Absetzen des auslösenden Medikaments eine hochdosierte IVIG-Therapie über 2 Tage durchgeführt werden.

Heparin-induzierte Thrombozytopenie Typ II HIT-Patienten mit längerer Thrombozytopenie, die auf eine Standardbehandlung nicht ansprechen, könnten von einer IVIG-Therapie profitieren.

Idiopathische Immunthrombozytopenie Bei der Immunthrombozytopenie bekommt die Verwendung von TPO-Rezeptor-Agonisten bei Notfallpatienten in Kombination mit First-Line-Wirkstoffen einen höheren Stellenwert.
Was ist neu bei der Diagnostik und Therapie des Nierenzellkarzinoms?
Authors: Ahrens Marit , Hartmann Arndt , Bergmann Lothar
Published: June 2020

Was ist neu?

Histologische Entitäten Die histopathologische Einteilung der Nierenzellkarzinome (RCC) wurde auch unter Berücksichtigung der molekularen Charakteristiken überarbeitet und als neue WHO-Klassifikation 2016 publiziert. Weiterhin wurde eine S3-Leitlinie zur Diagnostik, Therapie und Nachsorge des Nierenzellkarzinoms publiziert.

Therapie In der Erstlinientherapie des metastasierten RCC sind Kombinationstherapien mit dem Tyrosinkinasehemmer (TKI) Axitinib und den Immuncheckpoint-Inhibitoren (IO) Pembrolizumab oder Avelumab, unabhängig vom Risikoprofil und histologischer Entität, und die Kombination Ipilimumab mit Nivolumab bei Patienten mit intermediärem und hohem Risikoprofil neuer Standard. Ab der Zweitlinientherapie können nach einer Kombinationstherapie von TKI+IO oder IO + IO Medikamente, besonders TKI (z. B. Cabozantinib, Sunitinib), gegeben werden, die noch nicht zuvor eingesetzt wurden. Die Evidenzlage nach Kombinationstherapien ist gering.

Neue Nebenwirkungen Die Immuncheckpoint-Inhibitoren können mit immunvermittelten Nebenwirkungen unterschiedlichen Schweregrads einhergehen. Betroffen sind vor allem der Gastrointestinaltrakt, Leber, Lunge, Haut und endokrine Organe. Eine rasche Diagnostik und ggf. Therapie mit Immunsuppressiva sind essenziell.
Symptom Presentation After Concussion and Pre-existing Anxiety Among Youth Athletes
Authors: Kent Matthew , Brilliant Anna , Erickson Kirk , Meehan William , Howell David
Published: June 2020

Our purpose was to evaluate the effect of self-reported pre-injury anxiety diagnosis on persistent symptom development, vestibular symptom severity, and balance control among youth who sustained a concussion. We performed a retrospective study of patients seen at a specialty pediatric concussion clinic. Patients were 18 years of age or younger, examined within 10 days of concussion, and received care until full recovery. A questionnaire was used to assess pre-existing medical and psychiatric conditions, including anxiety. Our main outcomes were prolonged symptom recovery defined as persistent symptoms for > 28 days after concussion) and severity of vestibular symptoms. Patients who reported pre-injury anxiety (n=43; median age=14.9 years; 37% female) were more likely to experience symptoms>28 days post-injury (76 vs. 54%; p=0.04) than those without pre-existing anxiety (n=241; median age=14.9 years; 53% female). After adjusting for sex, history of migraine, depression and ADHD, however, there was no independent association between pre-existing anxiety and prolonged symptom duration (adjusted odds ratio=2.34; 95% CI=0.083–6.63; p=0.11). Pre-existing anxiety was independently associated with self-reported nausea/vomiting severity (β coefficient=0.59, 95% CI=0.07–1.11). A pre-existing anxiety diagnosis does not appear to be associated with persistent symptoms after concussion, although it may be associated with post-injury nausea.
ERCP with overtube-assisted enteroscopy in patients with Roux-en-Y gastric bypass anatomy: a systematic review and meta-analysis
Authors: Klair Jagpal Singh , Jayaraj Mahendran , Chandrasekar Viveksandeep Thoguluva , Priyan Harshith , Law Joanna , Murali Arvind R. , Singh Dhruv , Larsen Michael , Irani Shayan , Kozarek Richard , Ross Andrew , Krishnamoorthi Rajesh
Published: June 2020

Background Endoscopic retrograde cholangiopancreatography (ERCP) in patients with Roux-en-Y gastric bypass (RYGB) anatomy is challenging. Overtube-assisted enteroscopy (OAE) is usually needed to perform ERCP in these patients. There is significant variation in the reported rates of success and adverse events across published studies. We performed a systematic review and meta-analysis to reliably estimate the pooled rates of success and adverse events.

Methods We performed a systematic search of multiple electronic databases through February 2020 to identify studies reporting outcomes of OAE-ERCP in post-RYGB patients. The pooled rates of enteroscopy success, technical success, and adverse events were estimated for OAE-ERCP. The pooled rates of success and adverse events were also estimated for ERCP using double-balloon enteroscopes (DBE) alone.

Results 10 studies reporting a total of 398 procedures were included in the meta-analysis. The pooled rates of enteroscopy and technical success of OAE-ERCP were 75.3 % (95 % confidence interval [CI] 64.5 – 83.6) and 64.8 % (95 %CI 53.1 – 74.9) respectively. The pooled rate of adverse events was 8.0 % (95 %CI 5.2 – 12.2). The pooled rates of enteroscopy and technical success of DBE-ERCP (four studies) were 83.5 % (95 %CI 68.3 – 92.2) and 72.5 % (95 %CI 52.3 – 86.4), respectively. The pooled rate of adverse events with DBE-ERCP was 9.0 % (95 %CI 5.4 – 14.5). Substantial heterogeneity was noted.

Conclusions OAE-ERCP appears to be effective and safe in post-RYGB patients. Among the currently available techniques, OAE-ERCP is the least invasive approach in this challenging group of patients. Future studies comparing the effectiveness and safety of alternative novel techniques, such as endosonography-directed transgastric ERCP, with OAE-ERCP are needed.
Site-Selective Suzuki–Miyaura Reaction of 6,8-Dichloro-1,2,4-triazolo[4,3-a]pyridines
Authors: Langer Peter , Kuhrt David , Ehlers Peter , Spannenberg Anke
Published: June 2020

Triazolopyridines have found various applications as pharmaceuticals, agrochemicals, or optical materials. Consequently, the introduction of various functionalities at specific sites of this heterocyclic framework is of great importance. In this regard, we report the development of a site-selective Suzuki–Miyaura reactions leading to substituted triazolopyridines at positions 6 and 8. Under optimized conditions, the respective products have been obtained with high selectivity and yield.
Synthesis of 5- and 6-Azaindoles by Sequential Site-Selective Palladium-Catalyzed C–C and C–N Coupling Reactions
Authors: Dang Tuan Thanh , Langer Peter , Son Nguyen Thi , Tien Tuan Anh Nguyen , Ponce Marian Blanco , Ehlers Peter , Thuan Ngo Thi
Published: June 2020

Two-step sequential procedures for the Pd-catalyzed synthesis of 5- and 6-azaindoles are reported. The reactions proceed in very good yields. 6-Azaindoles are formed through site-selective Pd-catalyzed Sonogashira reaction of 3,4-dibromopyridine with alkynes, followed by a Pd-catalyzed tandem C–N coupling and cyclization with amines. On the other hand, 5-azaindoles are obtained by a site-selective Pd-catalyzed C–N coupling reaction of 3,4-dibromopyridine with amines, followed by C–C coupling and cyclization with alkynes.
Traditional Atriopulmonary Connection Fontan with Excellent Outcome for 32 Years
Authors: Zhang Yong , Fang Minhua , Wang Zengwei , Wang Huishan
Published: June 2020

Although the traditional right atrial–pulmonary artery (RA–PA) Fontan has been replaced by the total cavopulmonary connection, some RA–PA Fontan patients still have good outcome. We report a 37-year-old male who underwent traditional Fontan 32 years ago with the diagnosis of L-transposition of great arteries, subvalvular pulmonary stenosis and cardiac dextroversion. Among the recent CTA, electroconvulsive therapy, catheterization and angiography, pulsatile PA, uniform pulmonary blood, normal PA pressure and resistance were observed in this patient. The traditional RA–PA Fontan may be an alternative surgical procedure.
Homoeoprophylaxis—A Summary of Latest Developments
Authors: Golden Isaac
Published: June 2020

This article (1) reports on a conference in Delhi in January 2020 directed toward building the evidence base of homoeoprophylaxis, (2) summarizes the latest evidence base supporting the effectiveness of homoeoprophylaxis and (3) advises readers of a change in long-term endemic homoeoprophylaxis programme.
Homoeopathy in the Treatment of Chronic Spontaneous Urticaria: A Case Report
Authors: Dutta Abhijit , Nath Ranita , Ghosh Shubhamoy
Published: June 2020

Urticaria or nettle rash is an inflammatory clinical condition principally due to hypersensitive reaction manifest as wheals and/or angioedema at various locations of the body. Chronic spontaneous urticaria constitutes a small percentage among the class of urticaria in which recurrence persists for more than 6 months without any identifiable cause. However, mostly, it is idiopathic, and very rarely it represents some serious internal disease. Clinical history and some special biochemical markers help in making the diagnosis.

A patient suffering from chronic spontaneous urticaria of 2-year duration, which showed a poor response to conventional treatment, has been presented here. After a thorough clinical evaluation, Hepar sulphuris 6c, and in successive visits, Hepar sulphuris 30c were prescribed when needed. The response and severity of the case were evaluated by using patient-reported Visual Analogue Scale and Chronic Urticaria Quality of Life Scale at the baseline and subsequent visits. The case responded very well with no further recurrence in successive 6 months after the completion of the treatment.

This case report demonstrates improvement of symptoms as well as the reduction in the recurrence of such chronic and complicated cases of urticaria with homoeopathic treatment.
Prevention of Venous Thromboembolism in Hospitalized Medically Ill Patients: A U.S. Perspective
Authors: Spyropoulos Alex C. , Ageno Walter , Cohen Alexander T. , Gibson C. Michael , Goldhaber Samuel Z. , Raskob Gary
Published: June 2020

Venous thromboembolism (VTE) remains a major cause of morbidity and mortality in hospitalized medically ill patients. These patients constitute a heterogeneous population, whose VTE risk is dependent upon the acute medical illness, immobility status, and patient-specific risk factors that have been incorporated into individualized VTE risk assessment models. Randomized placebo-controlled trials (RCTs) have shown both efficacy and net clinical benefit of in-hospital thromboprophylaxis, which is supported by guideline recommendations. The data for extended posthospital discharge thromboprophylaxis are more nuanced. RCTs comparing standardized duration low-molecular weight heparin versus extended duration direct oral anticoagulants, such as betrixaban and rivaroxaban, have shown efficacy and net clinical benefit in select groups of high VTE and low-bleed risk populations of hospitalized medically ill patients. These oral agents are now approved for both in-hospital and extended thromboprophylaxis. However, the most recent guidelines do not recommend routine use of these agents for extended thromboprophylaxis. Longitudinal studies in medically ill patients have shown that the majority of VTE events occur in the posthospital discharge setting within 6 weeks of hospitalization. This, coupled with the short hospital length-of-stay and lack of routine postdischarge thromboprophylaxis in U.S. health care settings, has dampened quality improvement efforts aimed at reducing hospital-acquired VTE. The aim of this multidisciplinary document is to provide an evidence-based framework to guide clinicians in assessing VTE and bleeding risk in hospitalized medically ill patients using an individualized, risk-adapted, and patient-centered approach, with the aim of providing clinical pathways toward the use of appropriate type and duration of available thromboprophylactic agents.
EHR-Independent Predictive Decision Support Architecture Based on OMOP
Authors: Unberath Philipp , Prokosch Hans Ulrich , Gründner Julian , Erpenbeck Marcel , Maier Christian , Christoph Jan
Published: June 2020

Background The increasing availability of molecular and clinical data of cancer patients combined with novel machine learning techniques has the potential to enhance clinical decision support, example, for assessing a patient's relapse risk. While these prediction models often produce promising results, a deployment in clinical settings is rarely pursued.

Objectives In this study, we demonstrate how prediction tools can be integrated generically into a clinical setting and provide an exemplary use case for predicting relapse risk in melanoma patients.

Methods To make the decision support architecture independent of the electronic health record (EHR) and transferable to different hospital environments, it was based on the widely used Observational Medical Outcomes Partnership (OMOP) common data model (CDM) rather than on a proprietary EHR data structure. The usability of our exemplary implementation was evaluated by means of conducting user interviews including the thinking-aloud protocol and the system usability scale (SUS) questionnaire.

Results An extract-transform-load process was developed to extract relevant clinical and molecular data from their original sources and map them to OMOP. Further, the OMOP WebAPI was adapted to retrieve all data for a single patient and transfer them into the decision support Web application for enabling physicians to easily consult the prediction service including monitoring of transferred data. The evaluation of the application resulted in a SUS score of 86.7.

Conclusion This work proposes an EHR-independent means of integrating prediction models for deployment in clinical settings, utilizing the OMOP CDM. The usability evaluation revealed that the application is generally suitable for routine use while also illustrating small aspects for improvement.
Morphological Classification of the Zygomatic Regions in Young Chinese Han Males and Females Based on a Simulated Moiré Pattern
Authors: Wang Guanhuier , Chen Lujia , Feng Ning , Wu Siqiao , Zhao Jianfang , Li Dong
Published: June 2020

The complex curved contours of the zygomatic regions are difficult to analyze. Therefore, a better evaluation medium must be developed. We aimed to examine and summarize the morphological characteristics of the zygomatic region by using a moiré pattern map and computer algorithm. In this cross-sectional study, we collected three-dimensional images of the facial contours of 251 Han Chinese youth and established a morphological moiré map database. Clustering analysis using a computer algorithm was applied to obtain the zygomatic morphologies for classification. Aesthetic evaluation was performed to summarize the characteristics of the zygomatic types and provide reference for the preoperative morphological design of the midface. Zygomatic regions were morphologically classified into five types. Each type had its typical feature in the moiré pattern map. The moiré stripes in the left zygomatic region formed an “Ω” shape outward and downward in type 1, and they tended to be diagonal like “\\\” in type 2, smoothly curved like “)))” in type 3, vertical like “|||” in type 4, and diagonal like “///” in type 5. The aesthetic evaluation outcome indicated that the integrally flat zygoma (type 4) was more aesthetically pleasing among males, and the integrally prominent zygoma (type 3) was more aesthetically pleasing among females. Five morphological contour types of the zygoma were classified among the Chinese Han males and females based on the simulated moiré pattern. This morphological classification would aid in preparing a guide for clinical diagnosis and surgical planning.