bluuebunny/crossref_metadata_2025 huggingface dataset:
Biofeedback on eretic disfunction and quality of life in post radical prostatectomy patients: a systematic review
Authors: Araújo Marcelo Vinícius de Lima , Silva Maria Marina Siqueira da , Nogueira Teresa Augusta da Penha Lustosa , Silva Andrea Lima da , Dutra Cintia Maria da Silva , Barros Manuella da Luz Duarte
Published: February 2023

Prostate cancer is the most prevalent cancer in the male population, and although the gold standard treatment is radical prostectomy, it is common for unwanted effects to arise, such as erectile dysfunction and emotional problems. A tool that helps in the treatment of erectile dysfunction is the biofeedback, which acts through the visualization and recording of pelvic floor muscle contractions. The objective of this systematic review was to investigate if biofeedback improves erectile function and quality of life in patients after radical prostatectomy. Articles were searched in the databases PUBMED, LILACS, PEDro, and SCIELO, using the descriptors "erectile dysfunction", "quality of life" and "prostatectomy". Throughout the study, it was observed that the use of biofeedback probably reveals a positive effect on erectile function, and may significantly interfere with the quality of life of the study population. We suggested, therefore, the production of more articles due to the scarce number of interventional studies on the theme.
A integração fisiopatológica entre a COVID-19 e o Diabetes Mellitus Tipo 2 e a influência sobre o prognóstico dos pacientes: Uma revisão de literatura
Authors: Guedes Giovanna Leone Silva , Machado Heitor , Nunes Beatriz Carnevalli Motta , Caldeira Ana Carolina Resende , Fernandes Maria Eduarda Maia , Murad Julia Messias , Capellini Carolina Teixeira , Luca Luiza Garcia de , Cardenas Maria Fernanda Marques , Nunes Marilene Rivany
Published: February 2023

Introdução: A pandemia da COVID-19 abalou os alicerces das sociedades modernas, trazendo inúmeros questionamentos acerca do seu funcionamento, os quais devem ser analisados, sobretudo pela interrelação com doenças crônicas, como o Diabetes. Objetivo: O presente estudo teve como objetivo avaliar os pontos de convergência patogênica entre a infecção pelo SARS-CoV-2 e o Diabetes Mellitus Tipo 2, bem como o efeito sobre o prognóstico dos pacientes. Materiais e Métodos: Trata-se de uma revisão integrativa de literatura acerca da integração fisiopatológica entre a COVID-19 e o Diabetes Mellitus Tipo 2. Utilizou-se a estratégia PICO para a elaboração da pergunta norteadora. Ademais, realizou-se o cruzamento dos descritores “COVID-19”; “Diabetes Mellitus”; “Fisiologia”, nas bases de dados National Library of Medicine (PubMed MEDLINE), Scientific Eletronic Library Online (SCIELO), Ebscohost, Google Scholar e Biblioteca Virtual de Saúde (BVS). Resultados e Discussão: Uma parcela significativa dos artigos indicou uma interrelação entre os mecanismos fisiopatológicos da COVID-19 e o Diabetes Mellitus Tipo 2, sobretudo na exacerbação da resposta imune e dos danos diretos às células pancreáticas, os quais resultam em pior prognóstico da infecção viral. Conclusão: Foi possível perceber que as duas doenças possuem pontos de interação patogênica, reforçando a necessidade de ressignificar o processo de saúde-doença, objetivando compreender o funcionamento adequado dos mecanismos fisiopatológicos próprios de cada uma delas.
COVID-19: Imunopatologia e danos teciduais
Authors: Klinkonsky Flávia Vitória , Vieira Alanna Beatriz , Besson Jean Carlos Fernando
Published: February 2023

No último ano, todas as nações vêm vivenciando o avanço da pandemia viral pelo novo coronavírus. Dessa forma, os pesquisadores iniciaram uma intensa busca por informações claras e corretas, a fim de encontrar uma maneira de conter o seu avanço. O presente projeto de pesquisa tem como objetivo sintetizar os principais pontos sobre o SARS-CoV-2, seus mecanismos imunopatológicos e de agressão ao hospedeiro, por meio de levantamento de dados com base em publicações recentes. Através da revisão da literatura, foi concluído que, após a infecção do hospedeiro, danos teciduais em diversos órgãos podem acarretar lesões agudas e sequelas após eliminação do patógeno. Por fim, foi visto a relação entre a vacina e a redução de complicações pela doença.
Prevalence of head louse infestation among primary schoolchildren in the Republic of Korea: nationwide observation of trends in 2011-2019
Authors: Ryoo Seungwan , Hong Sooji , Chang Taehee , Shin Hyejoo , Park Jae Young , Lee Jeonggyu , Nah Eun-Hee , Lee Eun Hee , Jung Bong-Kwang , Chai Jong-Yil
Published: February 2023

Head louse infestation is a significant public health problem across the world, particularly among preschool and primary schoolchildren. This study investigated the trends of head louse infestation in the Republic of Korea over a 9-year period (2011-2019), targeting primary schoolchildren in 3 areas of Seoul, 4 other large cities, and 9 provinces. A survey was administered annually by the health staff of each regional office (n= 16) of the Korea Association of Health Promotion (KAHP). The branch offices of KAHP examined a total of 51,508 primary schoolchildren, comprising 26,532 boys and 24,976 girls. Over the 9-year survey, a total of 1,107 (2.1%) schoolchildren tested positive for adults and/or nits of Pediculus humanus capitis. The prevalence was 2.8% (133/4,727) in 2011-2012 and gradually decreased to 0.8% (49/6,461) in 2019 (P< 0.05). Head lice were found more frequently in girls (3.0%; 746/24,976) than in boys (1.4%; 361/26,532) (P< 0.05). In terms of geographic localities, the highest infestation rate, 4.7% (average prevalence over 9 years), was observed in southern Seoul (Gangnam branch of KAHP), whereas the lowest infestation rate, 0.7%, was seen in Gyeongsang (north and south provinces) and western Seoul. Although the prevalence decreased significantly during the 9-year period, head louse infestation remains a health and hygiene issue among primary schoolchildren in the Republic of Korea. Regular surveys along with health education are needed to further improve children’s hair hygiene.
Babeisa duncani infection alters gut microbiota profile in hamsters
Authors: Zhang Shangdi , Wang Jinming , Li Xiaoyun , Wang Yanbo , Nian Yueli , You Chongge , Zhang Dekui , Guan Guiquan
Published: February 2023

The genus Babesia includes parasites that can induce human and animal babesiosis, which are common in tropical and subtropical regions of the world. The gut microbiota has not been examined in hamsters infected by Babesia duncani. Red blood cells infected with B. duncani were injected into hamsters through intraperitoneal route. To evaluate the changes in gut microbiota, DNAs were extracted from small intestinal contents, acquired from hamsters during disease development. Then, the V4 region of the 16S rRNA gene of bacteria was sequenced using the Illumina sequencing platform. Gut microbiota alternation and composition were assessed according to the sequencing data, which were clustered with >97.0% sequence similarity to create amplicon sequence variants (ASVs). Bacteroidetes and Firmicutes were made up of the major components of the gut microbiota in all samples. The abundance of Bacteroidetes elevated after B. duncani infection than the B. duncani-free group, while Firmicutes and Desulfobacterota declined. Alpha diversity analysis demonstrated that the shown ASVs were substantially decreased in the highest parasitemia group than B. duncani-free and lower parasitemia groups. Potential biomarkers were discovered by Linear discriminant analysis Effect Size (LEfSe) analysis, which demonstrated that several bacterial families (including Muribaculaceae, Desulfovibrionaceae, Oscillospiraceae, Helicobacteraceae, Clostridia UGG014, Desulfovibrionaceae, and Lachnospiraceae) were potential biomarkers in B. duncani-infected hamsters. This research demonstrated that B. duncani infectious can modify the gut microbiota of hamsters.
Basel Bank Limiting Policies as Foucauldian Power/Knowledge: Risk as Assemblages, The Case of Basel Bank Limiting Policies as Discourses
Authors: Patomäki Joel
Published: February 2023

I intend to write about Basel bank's limiting technologies from the point of view of trust, coming from the fact that banks have to adjust their risk understanding tools and test them constantly.
It is not always known what exactly causes a risk. I am interested in risk-understanding technologies which do not govern this in advance but only require passing certain risk tests. Therefore, I will research the idea of Basel’s bank limiting technologies as assemblages that want connections only with other specified assemblages. For example, certain risk levels must be adjusted to form a harmonious whole that passes these tests. I will argue that by understanding Basel’s bank limiting technologies through the theory of assemblages, it is possible to spell out the notion of biopower in the assemblage that has only a purely economic or statistical status.
This biopower means the ability of a certain bank to control its assessments by estimating those same forms in different diagrams. I will work with the condition that there are no rules as to how to control the risks, only of what the abstract risk levels must be. This is based on the standpoint of the assemblage theory's idea that certain particles can be removed because the particles are tied to the whole. The point of this analysis is to show that trust does not lie in mutual understanding, but rather in the abstract risk levels and certain tests that the bank has to go through.
Trust is not created by doing something that would restrict the bank’s ability to act by itself, but by making sure that the governor knows that the bank is in trouble if it does not keep risk at a certain level compared to rules that would govern how the bank has to act. It does this by using a technique that ties the bank’s risks to the tools with which it normally functions. Therefore, it cannot cheat the system by using different tools to profit from excessive risks.
This system of certain risk technologies tied to both sides of the bank’s infrastructure is called M.A.D. (Mutually Assured Destruction) because it does not show one side without the other. Therefore, biopower is applied to the bank’s risk technologies by making sure that bank knows how to work for its well-being and at the same time also ensures that it works for the general good. This sounds a lot like an invisible hand that makes individuals’ actions beneficial to the whole community. This idea seems to develop more instrumentally in this argument, but there is the same “clever lie” behind it.
DETEKSI JALAN BERLUBANG MENGGUNAKAN METODE GREY LEVEL CO-OCCURRENCE MATRIX DAN NEURAL NETWORK
Authors: Mahrus ali Muhammad Mahrus
Published: February 2023

Faktor utama yang menjadi penentu kelayakan kondisi suatu jalan yaitu kerusakan pada aspal sehingga pemeliharaan jalan perlu dilakukan secara berkala. Pemeriksaan kondisi jalan dilakukan oleh petugas survey dengan melakukan pengamatan langsung pada jalan yang akan diberikan penilaian secara manual. Aktifitas pemeriksaan dapat mengganggu kelancaran arus lalu lintas pada jalan yang padat kendaraan terlebih lagi dapat membahayakan keselamatan petugas survey. Diperlukan alternative pemeriksaan jalan untuk menghindari ancaman yang tidak diinginkan dan dapat membiat biaya lebih efektif. Pada penelitian ini dikembangkan suatu system deteksi jalan berlubang menggunakan data video, dengan menerapkan metode Gray Level Co-occurrence Matrix (GLCM) dan klasifikasi menggunakan Neural Network. Deteksi terdiri atas 2 tahapan, dimulai dengan mengekstraksi ciri citra jalan kemudian ditraining dengan pemberian label manual. Kemudian dilakukan uji data citra berdasarkan nilai pada data training. Dari pengujian Confusion Matrix menunjukkan hasil Recall sebesar 0,80 hasil Precission sebesar 0,06 hasil Accuracy sebesar 0,79 dan hasil Error Rate sebesar 0,20.
APLIKASI INVENTARIS SEKOLAH BERBASIS WEB MENGGUNAKAN FRAMEWORK DJANGO DI MTS. NURUL HIDAYAH SUMBERREJO PAITON
Authors: Tholib Abu , Fauziah Gustin
Published: February 2023

Inventaris merupakan suatu kegiatan pencatatan, pelaporan serta pengolahan data-data barang yang tersedia di sekolah. Beberapa instansi pendidikan di Indonesia belum memiliki sistem yang menyediakan informasi inventaris sekolah. Padahal pengelolaan inventaris yang baik sangat penting bagi kelancaran sarana dan prasarana sekolah. Proses inventarisasi di MTs. Nurul Hidayah Sumberrejo Paiton masih dilakukan secara konvensional yaitu dengan mencatat ke buku inventaris kemudian data diinputkan ke dalam Microsoft Excel. Hal ini membutuhkan waktu yang cukup lama dalam pembuatan laporan inventaris serta mempersulit proses pencarian data barang tertentu. Berdasarkan permasalahan diatas maka dibuat  sebuah aplikasi inventaris sekolah berbasis web menggunakan framework django dengan memanfaatkan teknologi QR Code dengan menggunakan bahasa pemrograman Python yang dapat memudahkan karyawan tata usaha dalam melakukan proses inventarisasi dan menyediakan informasi sesuai kebutuhan. Hasil penelitian adalah sebuah Aplikasi Inventaris Sekolah Berbasis Web Menggunakan Framework Django yang dapat digunakan untuk mempercepat proses inventarisasi serta membantu petugas dalam penyusunan laporan. Hasil pengujian aplikasi dengan responden sebagai user bahwa aplikasi inventaris sekolah berbasis web menunjukkan persentase pada pertanyaan 1 yaitu sebesar 70% (Setuju), pertanyaan 2 sebesar 75% (Sangat Setuju), pertanyaan 3 sebesar 75% (Sangat Setuju), pertanyaan 4 sebesar 70% (Setuju), pertanyaan 5 sebesar 70% (Setuju), dan pertanyaan 6 sebesar 75% (Sangat Setuju). Rata-rata hasil pengujian dengan responden sebesar 72,5% yang memiliki arti bahwa aplikasi ini sangat baik dan responden sangat setuju untuk menggunakan aplikasi.
Sistem Informasi Produksi dan Penjualan Pada Unit Usaha Produksi Beras UD. Surya Kencana Probolinggo
Authors: Khairi Matlubul , Bahar Hasbul
Published: February 2023

Beras merupakan komuditas pangan yang paling banyak dikonsumsi oleh masyarakat Indonesia. Salah satu unit usaha yang memproduksi beras adalah UD. Surya Kencana Probolinggo. Sistem manajemen yang belum terkomputerisasi menyebabkan beberapa permasalahan yaitu Pemantauan stok produksi untuk pemenuhan permintaan kurang efektif dan kurang valid, lamanya pembuatan laporan penjualan, pembelian, rugi/laba dan terdapat beberapa transaksi yang kurang terbaca akibat lunturnya tulisan. Metode yang digunakan dalam pembangunan system informasi ini adalah metode prototype. Alat yang digunakan dalam perancangan system yaitu use case diagram dan activity diagram. Penelitian ini menghasilkan system berbasis destop menggunakan database MySQL yang dijalankan secara client server di masing-masing pengguna yaitu Administrator, Kasir dan Gudang. Hasil pengujian black box menunjukan bahwa system ini berjalan tanpa error. System ini sangat layak diimplentasikan berdasarkan persentase kelayakan responden mencapai 85%
Restraining Sub-imperialism in Southern Rhodesia, 1889–1898
Authors: Bomholt Nielsen Mads
Published: February 2023

This article examines the relations between the British government and the British South Africa Company through the 1890s. It aims to explore the ways in which the imperial government sought to restrain and control the BSAC as a sub-imperial actor with its own distinct agenda and interests. While sub-imperial actors were a useful way to claim colonial hinterlands before rival colonial powers, they could also land the government in difficult and unwanted situations. The 1895 Jameson raid scandal and the rebellions of the Ndebele and Shona in 1896–7 necessitated government intervention and limitation of company privileges. Yet, while such situations were on a whole unwanted by the government, they also proved vital pretexts to limit, control and convert sub-imperialism to the imperial and geopolitical interests of the government.
Pengambilan Keputusan Dalam Pemilihan Tempat Peletakan Alat di Laboratorium Teknik Industri Berdasarkan Keterbatasan Ruang dengan Metode AHP
Authors: Tri Aji Wicaksono  , Andhika Mayasari  , Sulung Rahmawan Wira Ghani
Published: February 2023

Industrial engineering laboratory is an important component in a high-level learning in industrial engineering study program. The university wants a correct and proper layout for the placement of various kinds of learning support tools and practicums in the laboratory for Industrial Engineering students. There are 3 laboratory rooms, namely the Manufacturing Industry Laboratory, the Service Industry Laboratory, and the Industrial Integration System Laboratory. The research focused on the placement of laboratory equipment within the limited space available. This study aims to determine the priority criteria and alternative placement of the best laboratory equipment. The method used is AHP-TOPSIS, the AHP method is used for weighting the assessment criteria, while the TOPSIS method is used to sort the location of various laboratory equipment. The researcher determined that there were 4 criteria, namely the dimensions of the tool, the level of danger, maintenance, and the mobility of the tool. The conclusion that can be drawn is that the AHP-TOPSIS method can be used as a decision-making framework in selecting the right place for laying various laboratory equipment. Placement of tools that have the criteria of tool dimensions with heavy mass and mobility of tools that are often moved are placed in the Manufacturing Industry Laboratory.AHP, TOPSIS, laboratory, decision making
EVALUASI KESELAMATAN DAN KESEHATAN KERJA PADA PRAKTIKUM TEKNIK INDUSTRI UNIVERSITAS HASYIM ASYâ€™ARI DENGAN METODE JOB SAFETY ANALYSIS
Authors: Mochamad Dwi Rizky Dharmawan  , Sulung Rahmawan Wira Ghani
Published: February 2023

Every year, the number of accident cases in Indonesia has been increased. The latest data in 2018 showed that there were 157,313 cases involving work accidents. In the fact, the laboratory is a place or room equipped with equipment for conducting experiments (investigations and so on). The manufacturing process of one of the practicums by using a machine can cause noise that is not appropriate with Occupational Safety and Health (K3) and the place is also inseparable from the potential dangers or even the risk of work accidents from the tools and practicum materials for the practitioner. There were efforts to prevent and minimize the work accidents in the laboratory, one of which is by applying the Job Safety Analysis (JSA) method and increasing the knowledge of K3 (Occupational Health and Safety). The purpose of this study is to know the application of JSA and the knowledge of K3 of work accidents in the Hasyim Asy'ari University laboratory. The method of this researcher was that identifying and analyzing the risks that occur. The results showed the sequence of work, potential hazards and control efforts made from each hazard. In short, the application of this method hopefully able to make the practitioner aware of the dangers that occur if they do not comply with the JSA (Job Safety Analysis) that has been made previously.
Aimaraism: The Aimara in southern Peru under the lens of empirical historical evidence and linguistics. A nation that never existed.
Authors: Osorio Soto Gary
Published: February 2023

Currently, Peruvian society is experiencing a phenomenon of revalorization of the identity of the pre-viceroyalty, that is, the pre-Inca cultures; Aymarism is also part of this process of “re-elaboration”. Nevertheless, there are historical and archaeological elements that can reformulate the identity created by these Andean settlers of South America, especially those of southern Peru. In the territory of the southern Andes of Peru and the current republics of Argentina, Bolivia and Chile, both historical and archaeological evidence and linguistic archaeology contradict this narrative of “the Aymara”. This evidence transgresses the Aymara dialectic, breaking the narrative basis of a sociocultural origin in the extreme south of the western Andes of South America. In this sense, this research aims to answer the following questions ¿What is Aymara, What is Aymaraism, and where did it originate?, demonstrating through research the inconsistency between the Aymara dialectic and the empirical historical data.
Mapping of Holocene surface ruptures in the South Iceland Seismic Zone
Authors: Einarsson Páll
Published: February 2023

The South Iceland Seismic Zone is a transform zone marking the southern boundary of the Hreppar microplate. It is the source area of some of the most destructive earthquakes in Iceland’s history. The surface formations of the zone are ground moraines, alluvial plains and Postglacial lava flows, and show widespread evidence of Holocene faulting. The fractured area is 15 km wide and 70 km long. A project to map by GPS-instruments all recognizable Holocene fault structures in this zone is described here. A large majority of fractures strike NNE to NE and form left-stepping, en echelon arrays with a northerly trend. They are associated with right-lateral faulting at depth. Right-stepping arrays also exist, apparently associated with faulting onconjugate faults with ENE strike, but they are an order of magnitude less frequent and mostly of a secondary nature. Other fault trends also occur, but are rare. Push-up structures are prominent in association with the en echelon arrays, sometimes reaching heights of several meters. Fractures active during a few of the large, historical earthquakes in this region have been identified and traced, e.g. the 1630, 1784, 1896, and 1912 events. The fractures are found within narrow, N–S trending zones crossing the seismic zone. Thus the large-scale, left- lateral transform motion across the plate boundary is accommodated by right-lateral slip on a series of transverse faults arranged side by side within the zone and by slight rotation of the blocks between them, a process sometimes called "bookshelf tectonism". Fractures formed during the earthquakes of June 17 and 21 ($M_w$ = 6.5) in 2000 and May 29 in 2008 ($M_w$ = 6.3) follow this pattern and confirm this general model of faulting along the transform zone. The size of push-up structures gives a clear indication of relative sizes of the earthquakes. The push-ups formed in 1630 and 1912 are an order of magnitude larger than the ones formed in the 2000 and 2008 earthquakes.
Low-temperature alteration of basalts – the effects of temperature, acids and extent of reaction on mineralization and water chemistry
Authors: Stefánsson Andri
Published: February 2023

The weathering and low-temperature alteration of basaltic glass was studied by geochemical modelling in order to gain an insight into the effects of temperature, acid supply and extent of reaction on the secondary mineralogy and water chemistry. Basaltic glass was dissolved in dilute water at 10–150°C in a closed system and secondary minerals commonly observed in nature allowed to precipitate when saturated. The weathering of basalts in the presence of CO$_2$ was observed to go through three stages; initially simple insoluble Al and Fe hydroxides were formed. Upon progressive basaltic glass dissolution imogolite, allophane and/or kaolinite and Ca–Mg–Fe smectites predominated, decreasing the mobility of Al, Fe, Si, Ca and Mg whereas extensive weathering and alkaline pH values resulted in the formation of smectites, zeolites, calcite and SiO$_2$ minerals. Under low-temperature geothermal conditions and in strong H$_2$ SO$_4$ acid solutions (pH\<4) amorphous silica, kaolinite, Al–Fe oxyhydroxides and sulphur-containing minerals were most important and most cations like Na, K, Ca and Mg were observed to be mobile. Under mildly acid conditions in CO$_2$ enriched waters (pH 5–7) kaolinite, chalcedony, Ca–Mg–Fe smectites and Mg–Fe–Ca carbonates predominated and Fe, Al and Si were found to be immobile, whereas Mg and Ca mobility depended on the mass of carbonate formed and water pH. Under alkaline conditions (pH\>8) that resulted from a low acid supply and/or extensive basaltic glass dissolution chalcedony, celadonite, Ca–Mg–Fe smectites, zeolites and calcite were found to form, greatly reducing the mobility of most dissolved elements. The dominant factor determining the weathering and low-temperature alteration of basaltic glass and the associated elemental mobility is the pH of the water. In turn, the pH value is determined by the input and type of acid and their ionization constant and quantity of basaltic glass dissolution and secondary minerals formed that increases with the extent of the reaction and the temperature. The weathering mineralogy observed associated with basaltic glass in Iceland is typical of low to moderate degree of alteration under low (atmospheric) CO$_2$ conditions. The low-temperature regional geothermal alteration commonly observed in Iceland is also typical for low CO$_2$ alteration and the reaction order of celadonite and chalcedony, followed by mixed clays and chlorite and eventually zeolites and calcite, indicate increased water–rock interaction at pH>8 with temperature being less important on the overall reaction path.
Jöklabreytingar (Glacier variations) 1930–1970, 1970–1995, 1995–2007 og 2007–2008
Authors: Sigurðsson Oddur
Published: February 2023

Jöklaárið 2007–2008 (október til september) skar sig ekki úr því veðurlagi sem ríkt hefur á Íslandi frá því fyrir síðustu aldamót. Það var meðal 20 hlýjustu ára frá upphafi mælinga og úrkoma var ekki fjarri meðallagi. Helst var að úrkoma á Vestfjörðum var í meira lagi og hlynnti að Drangajökli að sínu leyti svo ekki rýrnaði hann að ráði þetta árið. Ekki reyndist unnt að mæla á 6 af þeim stöðum sem vitjað var. Á 41 stað telst jökulsporðurinn hafa styst en gengið fram á fimm stöðum. Athyglisverðast af því er framgangur á tveimur merkjum við austanverðan Skeiðarárjökul. Ekki virðist þó um framhlaup að ræða.
MODIFICAÇÃO DE USO (RETROFIT) DE EDIFICAÇÕES
Authors: Pereira Valdir Moraes , Fernandes Ana Carolina , Yoshikawa Nestor Kenji
Published: February 2023

A readequação/retrofit do layout interno de edificações pode ser realizada para modificação de uso, modernização de edificações e/ou para atender às exigências normativas atuais. Quando isso ocorre, é importante que seja feita uma análise estrutural da edificação visando verificar se esta possui capacidade de resistir aos carregamentos do novo uso, verificando se as novas cargas são compatíveis com a estrutura existente. Assim, o presente trabalho tem o objetivo de analisar os impactos da modificação do uso em uma edificação fictícia, considerando a modificação de uso residencial para o uso como uma escola. Para isso, foram realizados dois modelos estruturais (um para cada uso) e realizadas comparações por meio das diferenças percentuais entre as armaduras dimensionadas para os elementos estruturais da edificação. Os resultados mostraram que a modificação de uso ocasionou alterações dos esforços internos solicitantes e, consequentemente, na quantidade de aço necessária das lajes, vigas e pilares da edificação. As maiores alterações de quantidade de armadura foram verificadas nas lajes e vigas, que ocorreu em até, respectivamente, 72,7% e 50,0%; essas alterações não foram tão significativas nos pilares, cujas armaduras aumentaram em até 25,0%. Dessa forma, observou-se quantitativamente a necessidade da realização de uma análise estrutural de edificações quando estas são submetidas a modificação do uso devido aos novos carregamentos que podem ocorrer quando sua utilização é modificada.
MODELO DE MATURIDADE DIGITAL PARA EMPRESAS DE CONSTRUÇÃO CIVIL (MMDC)
Authors: Andrade Leandro Luiz de , Simões Eliane Antonio , Ribeiro Rosinei Batista , Luciano Érik Leonel , Piacente Fabricio José , Formigoni Alexandre
Published: February 2023

Considerando-se a necessidade da Transformação Digital das empresas de Construção Civil, neste trabalho apresenta-se um Modelo de Maturidade Digital da Construção Civil (MMDC) elaborado a partir da metodologia DSR (Design Science Research), composta por cinco etapas: compreensão do problema, geração de alternativas, desenvolvimento do artefato, avaliação e conclusões. O modelo desenvolvido possibilitou a avaliação em cinco empresas de construção civil nas sete dimensões consideradas: Cultura e Organização, Tecnologia, Estratégia, Clientes, Inovações, Ecossistema e Operações. Como resultado pode-se identificar o nível de maturidade para cada empresa, em cada uma das sete dimensões de análise, segundo os cinco níveis de maturidade definidos: M1 (não iniciado), M2 (inicial), M3 (gerenciado) e M4 (integrado e interoperável). Além disso, a avaliação permitiu indicar os caminhos necessários para a elevação dos seus níveis de maturidade digital.
REPRESENTAÇÕES SOCIAIS DE UPCYCLING NA FORMAÇÃO TÉCNICA EM MODA
Authors: Salgueiro Rafaela , Lima Rita de Cássia Pereira
Published: February 2023

A presente pesquisa objetivou investigar as representações sociais de upcycling por professores e alunos do curso de formação técnica em moda da FAETEC-RJ. Fundamentada na Teoria das Representações Sociais (TRS) e nos estudos sobre upcycling e sustentabilidade na moda, a pesquisa realizou entrevistas semiestruturadas contendo uma indução de metáfora. Os resultados foram analisados através da técnica de análise de conteúdo. Seguindo a abordagem sociogenética da TRS, buscou-se investigar os processos formadores da representação: O núcleo figurativo, presente no processo de objetivação, e sua possível ancoragem. Os resultados revelaram representações diferentes para alunos e professores, corroborando um importante ponto da Teoria das Representações Sociais: grupos diferentes podem formar diferentes representações sobre o mesmo objeto. Consideramos importante investigar como professores e alunos de uma escola de formação técnica em moda representam o objeto upcycling para que temas relacionados à sustentabilidade possam ser devidamente trabalhados nas matrizes curriculares. Acreditamos que investigando as representações sociais de upcycling para estudantes e docentes, contribuímos para uma reflexão crítica acerca das relações que se estabelecem na dinâmica de um curso de formação em Moda. Dessa forma, buscamos refletir sobre o tema, visando aprimorar e aprofundar no ensino de moda o tema upcycling e suas implicações no tripé viabilidade econômica, preservação ambiental e justiça social no qual se ampara a sustentabilidade.
Histone lysine methyltransferase-related neurodevelopmental disorders: current knowledge and saRNA future therapies
Authors: Roth Charlotte , Kilpinen Helena , Kurian Manju A. , Barral Serena
Published: February 2023

Neurodevelopmental disorders encompass a group of debilitating diseases presenting with motor and cognitive dysfunction, with variable age of onset and disease severity. Advances in genetic diagnostic tools have facilitated the identification of several monogenic chromatin remodeling diseases that cause Neurodevelopmental disorders. Chromatin remodelers play a key role in the neuro-epigenetic landscape and regulation of brain development; it is therefore not surprising that mutations, leading to loss of protein function, result in aberrant neurodevelopment. Heterozygous, usually de novo mutations in histone lysine methyltransferases have been described in patients leading to haploinsufficiency, dysregulated protein levels and impaired protein function. Studies in animal models and patient-derived cell lines, have highlighted the role of histone lysine methyltransferases in the regulation of cell self-renewal, cell fate specification and apoptosis. To date, in depth studies of histone lysine methyltransferases in oncology have provided strong evidence of histone lysine methyltransferase dysregulation as a determinant of cancer progression and drug resistance. As a result, histone lysine methyltransferases have become an important therapeutic target for the treatment of different cancer forms. Despite recent advances, we still lack knowledge about the role of histone lysine methyltransferases in neuronal development. This has hampered both the study and development of precision therapies for histone lysine methyltransferases-related Neurodevelopmental disorders. In this review, we will discuss the current knowledge of the role of histone lysine methyltransferases in neuronal development and disease progression. We will also discuss how RNA-based technologies using small-activating RNAs could potentially provide a novel therapeutic approach for the future treatment of histone lysine methyltransferase haploinsufficiency in these Neurodevelopmental disorders, and how they could be first tested in state-of-the-art patient-derived neuronal models.
ETV2 and VEZF1 interaction and regulation of the hematoendothelial lineage during embryogenesis
Authors: Das Satyabrata , Gupta Vinayak , Bjorge Johannes , Shi Xiaozhong , Gong Wuming , Garry Mary G. , Garry Daniel J.
Published: February 2023

Ets variant 2 (Etv2), a member of the Ets factor family, has an essential role in the formation of endothelial and hematopoietic cell lineages during embryonic development. The functional role of ETS transcription factors is, in part, dependent on the interacting proteins. There are relatively few studies exploring the coordinated interplay between ETV2 and its interacting proteins that regulate mesodermal lineage determination. In order to identify novel ETV2 interacting partners, a yeast two-hybrid analysis was performed and the C2H2 zinc finger transcription factor VEZF1 (vascular endothelial zinc finger 1) was identified as a binding factor, which was specifically expressed within the endothelium during vascular development. To confirm this interaction, co-immunoprecipitation and GST pull down assays demonstrated the direct interaction between ETV2 and VEZF1. During embryoid body differentiation, Etv2 achieved its peak expression at day 3.0 followed by rapid downregulation, on the other hand Vezf1 expression increased through day 6 of EB differentiation. We have previously shown that ETV2 potently activated Flt1 gene transcription. Using a Flt1 promoter-luciferase reporter assay, we demonstrated that VEZF1 co-activated the Flt1 promoter. Electrophoretic mobility shift assay and Chromatin immunoprecipitation established VEZF1 binding to the Flt1 promoter. Vezf1 knockout embryonic stem cells had downregulation of hematoendothelial marker genes when undergoing embryoid body mediated mesodermal differentiation whereas overexpression of VEZF1 induced the expression of hematoendothelial genes during differentiation. These current studies provide insight into the co-regulation of the hemato-endothelial lineage development via a co-operative interaction between ETV2 and VEZF1.
The auditory efferent system in mosquitoes
Authors: Loh YuMin M. , Su Matthew P. , Ellis David A. , Andrés Marta
Published: February 2023

Whilst acoustic communication forms an integral component of the mating behavior of many insect species, it is particularly crucial for disease-transmitting mosquitoes; swarming males rely on hearing the faint sounds of flying females for courtship initiation. That males can hear females within the din of a swarm is testament to their fabulous auditory systems. Mosquito hearing is highly frequency-selective, remarkably sensitive and, most strikingly, supported by an elaborate system of auditory efferent neurons that modulate the auditory function - the only documented example amongst insects. Peripheral release of octopamine, serotonin and GABA appears to differentially modulate hearing across major disease-carrying mosquito species, with receptors from other neurotransmitter families also identified in their ears. Because mosquito mating relies on hearing the flight tones of mating partners, the auditory efferent system offers new potential targets for mosquito control. It also represents a unique insect model for studying auditory efferent networks. Here we review current knowledge of the mosquito auditory efferent system, briefly compare it with its counterparts in other species and highlight future research directions to unravel its contribution to mosquito auditory perception.
Genetic liability to mental disorders in relation to the risk of hypertension
Authors: Huangfu Ning , Lu Yunlong , Ma Hongchuang , Hu Ziwei , Cui Hanbin , Yang Fangkun
Published: February 2023

Background

Observational studies have indicated that psychosocial factors contribute to hypertension; however, the causality of these associations remains unclear due to reverse causality and confounders. We aim to assess the causal associations of mental health disorders with hypertension.

Methods

Instrumental variables of anxiety disorder, attention deficit/hyperactivity disorder, autism spectrum disorder, depression, obsessive–compulsive disorder, post-traumatic stress disorder, schizophrenia, and subjective well-being measure were obtained from the corresponding largest genome-wide association studies. Summary statistics for the association of essential hypertension were obtained from the FinnGen Study (42,857 cases and 162,837 controls) and UK Biobank cohort (54,358 cases and 408,652 controls). The multiplicative random-effects inverse-variance weighted method was utilized as the primary analysis and three other statistical methods were conducted in the supplementary analyses. The results were combined using the fixed-effects method.

Results

In the pooled analyses, genetic liability to depression was associated with higher risk of hypertension (odds ratio [OR], 1.25; 95% confidence interval [CI], 1.17–1.35; p < 0.001). Besides, a suggestive association was found between genetically predicted higher weighted neuroticism sum-score and increased risk of hypertension (OR, 1.16; 95% CI, 1.02–1.33; p < 0.05). No associations were found for other mental health disorders. Sensitivity analyses revealed consistent evidence as the main results.

Conclusion

We provide consistent evidence for the causal effect of genetic liability to depression on hypertension, which highlights the importance of blood pressure measurement and monitoring in patients with depression.
Multichannel seismic impedance inversion based on Attention U-Net
Authors: Ning Juan , Li Shu , Wei Zong , Yang Xi
Published: February 2023

Recently, seismic inversion has made extensive use of supervised learning methods. The traditional deep learning inversion network can utilize the temporal correlation in the vertical direction. Still, it does not consider the spatial correlation in the horizontal direction of seismic data. Each seismic trace is inverted independently, which leads to noise and large geological variations in seismic data, thus leading to lateral discontinuity. Given this, the proposed method uses the spatial correlation of the seismic data in the horizontal direction. In the network training stage, several seismic traces centered on the well-side trace and the corresponding logging curve form a set of training sample pairs for training, to enhance the lateral continuity and anti-noise performance. Additionally, Attention U-Net is introduced in acoustic impedance inversion. Attention U-Net adds attention gate (AG) model to the skip connection between the encoding and decoding layers of the U-Net network, which can give different weights to different features, so the model can focus on the features related to the inversion task and avoid the influence of irrelevant data and noise during the inversion process. The performance of the proposed method is evaluated using the Marmousi2 model and the SEAM model and compared with other methods. The experimental results show that the proposed method has the advantages of high accuracy of acoustic impedance value inversion, good transverse continuity of inversion results, and strong anti-noise performance.
The association between acylcarnitine and amino acids profile and metabolic syndrome and its components in Iranian adults: Data from STEPs 2016
Authors: Taghizadeh Hananeh , Emamgholipour Solaleh , Hosseinkhani Shaghayegh , Arjmand Babak , Rezaei Negar , Dilmaghani-Marand Arezou , Ghasemi Erfan , Panahi Nekoo , Dehghanbanadaki Hojat , Ghodssi-Ghassemabadi Robabeh , Najjar Niloufar , Asadi Mojgan , khoshniat Mohsen , Larijani Bagher , Razi Farideh
Published: February 2023

Background

Evidence, albeit with conflicting results, has suggested that cardiometabolic risk factors, including obesity, type 2 diabetes (T2D), dyslipidemia, and hypertension, are highly associated with changes in metabolic signature, especially plasma amino acids and acylcarnitines levels. Here, we aimed to evaluate the association of circulating levels of amino acids and acylcarnitines with metabolic syndrome (MetS) and its components in Iranian adults.

Methods

This cross-sectional study was performed on 1192 participants from the large–scale cross-sectional study of Surveillance of Risk Factors of non-communicable diseases (NCDs) in Iran (STEP 2016). The circulating levels of amino acids and acylcarnitines were measured using liquid chromatography-tandem mass spectrometry (LC-MS/MS) in individuals with MetS (n=529) and without MetS (n=663).

Results

The higher plasma levels of branched-chain amino acids (Val, Leu), aromatic amino acids (Phe, Tyr), Pro, Ala, Glu, and the ratio of Asp to Asn were significantly associated with MetS, whereas lower circulating levels of Gly, Ser, His, Asn, and citrulline were significantly associated with MetS. As for plasma levels of free carnitine and acylcarnitines, higher levels of short-chain acylcarnitines (C2, C3, C4DC), free carnitine (C0), and long-chain acylcarnitines (C16, C18OH) were significantly associated with MetS. Principal component analysis (PCA) showed that factor 3 (Tyr, Leu, Val, Met, Trp, Phe, Thr) [OR:1.165, 95% CI: 1.121-1.210, P<0.001], factor 7 (C0, C3, C4) [OR:1.257, 95% CI: 1.150-1.374, P<0.001], factor 8 (Gly, Ser) [OR:0.718, 95% CI: 0.651-0.793, P< 0.001], factor 9 (Ala, Pro, C4DC) [OR:1.883, 95% CI: 1.669-2.124, P<0.001], factor 10 (Glu, Asp, C18:2OH) [OR:1.132, 95% CI: 1.032-1.242, P= 0.009], factor 11 (citrulline, ornithine) [OR:0.862, 95% CI: 0.778-0.955, P= 0.004] and 13 (C18OH, C18:1 OH) [OR: 1.242, 95% CI: 1.042-1.480, P= 0.016] were independently correlated with metabolic syndrome.

Conclusion

Change in amino acid, and acylcarnitines profiles were seen in patients with MetS. Moreover, the alteration in the circulating levels of amino acids and acylcarnitines is along with an increase in MetS component number. It also seems that amino acid and acylcarnitines profiles can provide valuable information on evaluating and monitoring MetS risk. However, further studies are needed to establish this concept.
A cell cycle–related lncRNA signature predicts the progression-free interval in papillary thyroid carcinoma
Authors: Li Shuang , Ran Ming-Yu , Qiao Hong
Published: February 2023

The cell cycle plays a vital role in tumorigenesis and progression. Long non-coding RNAs (lncRNAs) are key regulators of cell cycle processes. Therefore, understanding cell cycle–related lncRNAs (CCR-lncRNAs) is crucial for determining the prognosis of papillary thyroid carcinoma (PTC). RNA-seq and clinical data of PTC were acquired from The Cancer Genome Atlas, and CCR-lncRNAs were selected based on Pearson’s correlation coefficients. According to univariate Cox regression, least absolute shrinkage and selection operator (LASSO), and multivariate Cox regression analyses, a five-CCR-lncRNA signature (FOXD2-AS1, LOC100507156, BSG-AS1, EGOT, and TMEM105) was established to predict the progression-free interval (PFI) in PTC. Kaplan–Meier survival, time-dependent receiver operating characteristic curve, and multivariate Cox regression analyses proved that the signature had a reliable prognostic capability. A nomogram consisting of the risk signature and clinical characteristics was constructed that effectively predicted the PFI in PTC. Functional enrichment analyses indicted that the signature was involved in cell cycle– and immune-related pathways. Furthermore, we also analyzed the correlation between the signature and immune cell infiltration. Finally, we verified the differential expression of CCR-lncRNAs in vitro using quantitative real-time polymerase chain reaction. Overall, the newly developed prognostic risk signature based on five CCR-lncRNAs may become a marker for predicting the PFI in PTC.
En bloc resection of total thyroid and bilateral central compartment lymph nodes via a gasless transoral approach in papillary thyroid carcinoma
Authors: Sheng Xuren , Liu Jianjun , Fang Jing , Zheng Xucai , Wang Shengying
Published: February 2023

Introduction

The current study presents a preliminary exploration of en bloc resection via a gasless transoral approach in papillary thyroid carcinoma.

Objective

This study aimed to summarize and explore the efficacy and safety of en bloc resection of total thyroid and bilateral central compartment lymph nodes via a gasless transoral approach in patients with papillary thyroid carcinoma.

Methods

This study was conducted between January 2021 and December 2021. It involved 30 patients with bilateral papillary thyroid carcinoma who had undergone en bloc resection of the total thyroid and bilateral central compartment lymph nodes via a gasless transoral approach using a three-trocar and four-instrument technique at The First Affiliated Hospital of the University of Science and Technology of China. The key steps and difficulties of the operation were summarized, and the clinicopathological characteristics and surgical complications of patients were analyzed.

Results

All operations were successful without conversion to open surgery. The pathological diagnosis was bilateral papillary thyroid carcinoma. The mean maximum tumor diameter was 0.85 ± 0.51 cm (range 0.3–2.5 cm). There was no case of gross capsular invasion. The mean number of harvested central compartment lymph nodes was 11.36 ± 5.36. Central compartment lymph node metastases were found in 16 patients (53.3%) with a mean of 1.53 ± 2.39. On the other hand, lymphocytic thyroiditis was observed in 12 cases (40%), and microscopic capsular invasion was observed in five cases (16.6%). All patients had normal parathyroid hormone levels after the operation. However, one patient developed hoarseness after the operation due to injury of the recurrent laryngeal nerve branch, but there was no numbness of the mandible and lower lip or infection of the oral incision.

Conclusion

The study revealed that the three-trocar and four-instrument technique can be used in the en bloc resection of total thyroid and bilateral central compartment lymph nodes via a gasless transoral approach without disconnecting the thyroid isthmus. As a result, the operation is considered effective and safe. Therefore, this technique may be a better surgical method for patients with bilateral thyroid cancer and cosmetic needs.
Management of male erectile dysfunction: From the past to the future
Authors: Wang Chang-Ming , Wu Bao-Rui , Xiang Ping , Xiao Jun , Hu Xue-Chun
Published: February 2023

Erectile dysfunction is a common disease of the male reproductive system, which seriously affects the life quality of patients and their partners. At present, erectile dysfunction is considered as a social-psychological-physiological disease with complex etiology and various treatment methods. Oral PDE5I is the first-line treatment for erectile dysfunction with the advantages of high safety, good effect and non-invasiveness. But intracavernosal injection, hormonal replacement therapy, vacuum erection device, penile prosthesis implantation can also be alternative treatments for patients have organic erectile dysfunction or tolerance to PDE5I. With the rapid development of technologies, some new methods, such as low-intensity extracorporeal shock wave and stem cell injection therapy can even repair the organic damage of the corpora cavernosa. These are important directions for the treatment of male erectile dysfunction in the future. In this mini-review, we will introduce these therapies in detail.