bluuebunny/crossref_metadata_2025 huggingface dataset:
Особенности использования двух типов ДНК-маркеров при анализе десатураз у масличного льна (Linum usitatissimum L.)
Authors: Базанов Т. , Ущаповский И. , Логинова Н. , Минина Е. , Вересова П.
Published: November 2024

Масличный лен издавна возделывают для получения масла, которое используют во многих областях промышленности. Сфера его применения определяется соотношением жирных кислот (ЖК) в составе масла, которое зависит от активности различных ферментных систем, в том числе десатураз. В настоящее время селекция направлена на получение сортов с заранее запланированным соотношением ЖК. Применение методов маркер-ассоциированной селекции может ускорить этот процесс. Наиболее распространенными являются SSR- и SNP-маркеры. Изучены 13 сортов льна масличного с различным соотношением ненасыщенных ЖК с помощью SSR- и SNP-маркеров. В ходе SSR-исследования спроектировано и синтезировано 29 пар маркеров, но информативными оказались только 3 пары праймеров. Полученные ПЦР-продукты разделяли на генетическом анализаторе и анализировали методом ПЦР с детекцией флуоресценции в реальном времени с линейкой из 11 SNP-праймеров. По результатам кластерного анализа с использованием SSR-маркеров образцы льна разделились на 3 группы: в 1-ю вошли 8 сортов с высоким и средним содержанием α-линоленовой кислоты (АЛК), а во 2-ю и 3-ю группы --- низколиноленовые сорта. Исследованные SSR-маркеры могут быть использованы в маркер-ассоциированной селекции отбора сортов с низким содержанием АЛК. Анализ дендрограммы генетического подобия, полученной на основе SNP-маркеров, выявил их высокую разрешающую способность при дифференциации генотипов.
Modernization of the Public Governance System in the Age of Information Platforms : Monograph
Authors: Kud Aleksandr
Published: November 2024

The monograph considers scientific and theoretical as well as modern practical issuesof modernization of public governance in Ukraine and in the world using informationplatforms, defines the conditions and limitations of modernization processes and the currentstate of tools and digital solutions in platform governance, offers approaches tomodernization of public governance as a system by changing the regulatory framework andorganizational model “Government as a Platform” in creating greater public value, withoutlimitation to a single country, and mobilizing public and private resources to arrangevarious configurations of public services.For scientists and specialists in the field of public governance, digital and platformgovernance as well as teachers, postgraduates and students of higher educationalinstitutions who study in the specialty “Public Governance” and interdisciplinary specialty“E-Governance”.
The sugar industry's efforts to manipulate research on fluoride effectiveness and toxicity: A ninety-year history
Authors: Neurath Christopher
Published: November 2024

BACKGROUND: Extensive academic research has documented the tobacco industry's manipulation of science. Recently, scholars have begun examining the sugar industry’s use of similar tactics to downplay sugar’s role in obesity, diabetes, cardiovascular disease, and tooth decay. Archival records show sugar-industry-funded scientists criticized evidence linking sugar to these harms and deflected attention to other risk factors. Sugar’s connection to tooth decay has been the most difficult harm for the industry to deny. Evidence is emerging that the industry turned to promoting fluoride as the solution to tooth decay thereby averting calls for reducing sugar consumption. Newly accessible sugar and dental industry documents enable investigation into whether fluoride research was manipulated to deflect from sugar’s role in tooth decay, and later to defend fluoride when evidence of fluoride’s own harmful effects arose.METHOD: Internal documents from sugar and dental organizations were examined and compared to the published scientific record. The Industries Documents collection at the University of California San Francisco was the main source of records. Analysis was in the context of the current understanding of how vested interests manipulate science to defend their products.RESULTS: Records dating back to the 1930s demonstrate the sugar industry, sometimes in cooperation with dental interests, exaggerated fluoride’s effectiveness and downplayed safety concerns. The sugar industry’s science manipulation campaign preceded the better-known tobacco industry campaign defending cigarettes. Key leaders of the sugar industry’s campaign transferred to the tobacco industry, which then adopted many of the sugar industry’s tactics and financed research from some of the same sugar-conflicted scientists. Currently, a prominent safety issue with fluoride is developmental neurotoxicity. Evidence indicates that researchers with undisclosed conflicts of interest with sugar and allied industries produced biased reviews downplaying this risk.CONCLUSION: Recently available records reveal a long history of the sugar industry distorting fluoride science. Many of the sugar industry's tactics were later adopted by the tobacco industry and mirrored by industries involved in asbestos, lead, pesticides, climate change denial, and others. Researchers and policymakers should be aware of the distorted scientific record regarding fluoride effectiveness and toxicity.
Social Identity Explanations of System Justification: Misconceptions, Criticisms, and Clarifications – Supplementary Document
Authors: Rubin Mark
Published: November 2024

This document supplements our reply to Jost et al.’s (2023) rejoinder to our initial article on the social identity model of system attitudes (SIMSA; Rubin et al., 2023). We respond to issues that we did not address in our main reply. Specifically, we argue that: (1) like SIMSA, Tajfel (1981) considered general, non-ideological, psychological processes; (2) system justification theory also refers to general, non-ideological, social psychological processes; (3) Jost et al. confuse respecting people with respecting people’s beliefs; (4) SIMSA proponents do not ignore system justification theory’s three motives; and (5) SIMSA may help to explain Osborne et al.’s (2019) results. In addition, (6) we apologise if we mischaracterised some researchers’ theoretical affiliations, and we respond to Jost et al.’s (7) questions about ideology; (8) criticisms of Owuamalam et al.’s (2016) work; and (9) criticisms about the validity of Owuamalam and Spears’ (2020) pupil dilation measure.
Using Data Science for Social Good: Mapping Opportunity Youth
Authors: Stanley Zofia C. , Topaz Chad M.
Published: November 2024

Opportunity youth—individuals aged 16 to 24 who are disconnected from education and employment due to significant barriers—constitute a sizable yet underserved demographic whose marginalization leads to substantial social and economic costs. This paper demonstrates how data science can be harnessed for social good by mapping the distribution of opportunity youth across different regions. We develop an Opportunity Youth Index by integrating fragmented data from sources such as the American Community Survey, the Adoption and Foster Care Analysis and Reporting System, FBI Crime Data, and Bureau of Justice Statistics incarceration reports. Focusing on four key indicators—disconnected youth, youth in foster care, justice-impacted youth, and children with an incarcerated parent—we employ statistical methods and computational techniques to estimate local concentrations of opportunity youth. The resulting index provides insights for policymakers and community organizations, highlighting areas where targeted interventions can make the most impact. This work illustrates the potential of data science to address complex social issues and is presented in an accessible manner to engage a younger audience.
Assessing Emerging Markets through Transactional Dynamics: A New Multi-Dimensional Valuation Framework
Authors: Midha Joshua
Published: November 2024

This paper introduces a novel transaction-function model for valuing emerging markets, integrating machine learning, agent-based modeling, and multi-method valuation techniques. Traditional valuation models often rely on aggregated economic indicators such as GDP growth and inflation, which lack the granularity needed to capture the transactional dynamics and unique risk factors inherent to emerging markets. In contrast, the proposed model treats each market as a multi-dimensional function of individual transactions, analyzing these interactions through a multi-method framework that includes Discounted Cash Flow (DCF), comparables, precedent transaction, and multiples analysis. By incorporating machine learning algorithms, the model iteratively improves predictive accuracy, dynamically adjusting to new data in volatile and data-sparse environments. Additionally, agent-based simulations provide insights into behavioral responses to policy changes, regulatory shifts, and other market-specific conditions, offering a behavioral layer often missing from traditional approaches. Validation of this model demonstrates a marked improvement in predictive accuracy and adaptability compared to conventional models. This transaction-function approach provides investors and policymakers with a granular, data-driven tool for assessing the true growth potential of emerging markets, paving the way for more informed, context-sensitive investment decisions.
Kalergi and Hart-Celler(and Memetics): White Antifragility
Authors: Ohnemus Alexander Luke
Published: November 2024

Germ-line mutations are needed to change genes. Paying reparations for, and recognizing, white privilege may even benefit Northwestern Europeans.
A Study on Export Effectiveness: A Case Study of Nepal
Authors: Khatri Mukti Bahadur
Published: November 2024

Historically, in many countries around the world exports have a significant role in contributing to employment generation and sustain economic growth. So, this research analyses the effectiveness of export in Nepal by using a regression analysis for the periods of 1975-2021 of 47 annual time series. According to empirical findings, Nepalese RGDP has an inverse impact on export while RGDP of India, exchange rate of US Dollar and trade liberalization are insignificant. So, there is a need for structural transformation to improve productivity, reduce cost of factor inputs and create the right business as well as business friendly policy, favorable exchange rate, legal and political atmosphere to attract efficient business activity along with good governance which ultimately increases GDP growth; employment, export and capital inflows respectively in national economy and that improve quality of life.
Comparative Study of Soil Organic Carbon in Forest of National Park and Sacred Grove in Kathmandu Valley
Authors: Wagle Prakash Chandra
Published: November 2024

Soil organic carbon (SOC) represents a significant fraction of the global carbon pool and is vital for understanding the ecosystem functions that occur in soils. Forest types and management can have a significant impact on soil organic matter and, as a result, soil organic carbon. However, comparative studies of SOC with respect to forest management have been carried out to a limited extent. Thus, the study was carried out in the Shivapuri-Nagarjun forest and the pine forest of Gokarneshwor with the aim of comparing the SOC of the Shivapuri forest of Shivapuri Nagarjun National Park and the pine forest of Gokarneshwor. Soil samples were collected by the stratified random sampling method. The composite samples from the depths of 0–10 cm and 10–15 cm were taken, mixed properly, air dried, and tested in the laboratory. Soil organic carbon was measured using the modified Walkley and Black methods. The soil organic carbon of the Shivapuri-Nagarjun forest was found to be 91.11 tons/ha, and the pine forest was found to be 34.77 tons/ha on average. Further analysis interlinking plant residue and microbial activities and their implications for soil organic carbon could be beneficial in forest management decisions
Fundamental Reasons for Gender Discrimination in Nepalese Societies
Authors: Uprety Mina Devi
Published: November 2024

Gender is constructed in the circumstances of particular socio-economic arrangements and gets transmitted through a process of collective and social learning. Women and men are biologically as well as socially and culturally different which has led to involvement in different gender dealings. The well-managed system of gender inequality, differentiation, stratification, and discrimination, in which there is an uneven gender construction and distribution of rewards and punishment logic and treatment between men and women existed throughout all Nepali cultures including modern or so-called modern ones. The socialization of Nepali womanhood and manhood is associated with the connections and interconnections of caste/ethnic groups, religion, education, occupation, tradition, culture, and deep-rooted and embedded patriarchal ideologies and practices. The ideological representations of gender and gender socialization are central to the exercise of patriarchal values, cultural beliefs, and economic domination. While sociologists and feminists study the collective social inequalities and variations, they attempt to understand how different forms of unfairness interconnect and affect each other. In the same way, it is very difficult to realize gender suppression and subordination without also looking at the practice of men and women in diverse social milieus such as caste/ethnic groups, occupation, education, religion, and other social categories. In this context, this study provides an analysis of the main causes of the construction of gender discrimination and discriminatory gender relationships in Nepali societies within the background of different socio-cultural dimensions and standpoints.
Trends, Patterns and Effects of Remittance in Nepal
Authors: Thapa Keshav
Published: November 2024

Remittance refers the sending or transfer of cash or kinds received or sent or by individual or household from one place to another place within the country or our of country through the legal channel and it is important lifeline in many developing countries. Almost 25 percent GDP of Nepal coveraged by Remittance. The main purpose of this article is to analyzed trends, patterns, using areas, coverage of remittance and its’ social effects in Nepal. An article is prepared on the basis of available data /information related to remittance sent in Nepal. Other data/information has not been collected and analyzed by the Author rather than Remittance Transfer situation of Nepal and its social effects. The sources of information has been clearly mentioned and also given the references. Author has prepared this article maintaining the academic ethics and value. Secondary based quantitative information are analyzed and interpreted with inductive approach. Percent of household receiving the remittance almost three times increased since 1995/96 to 2010/11 and it is gradually increased until fiscal year 2017/18. Terai household received more remittance comparing to mountain and hills. Same way, more remittance are receiving by rural areas comparing to urban areas. The remittance is coverage the almost more than 25 percent GDP of Nepal. Largest amount of remittance utilize for food and cloths. However, there are huge effects of the remittance in Nepalese society (CBS, 2014, KC B.B. 2017 and Nepal Rastra Bank, FY 2018/19).
चट्याङ : जीवनचक्रको सहयोगी साथै खतरा
Authors: अधिकारी Adhikari पितृभक्त Pitribhakta
Published: November 2024

सामान्य रूपमा हेर्दा चट्याङ मानव जीवनको लागि अपरिहार्य प्राकृतिक प्रक्रिया भए पनि यसलाई दैविक तथा प्राकृतिक प्रकोपको रूपमा लिइन्छ । चट्याङ हेर्दा जति मनमोहक र सुन्दर देखिन्छ त्यति नै यसलाई खतरा र डरलाग्दो घटनाको रूपमा लिने गरिन्छ । वातावरणमा भएको जीवनचक्र (Ecosystem) चलाउनको लागि यसको ठुलो भूमिका रहेको हुन्छ । चट्याङ परेको बेलामा यसको तापक्रम तीस हजार डिग्री सेल्सियससम्म पुग्ने भएकाले जीवनको सुरुवात हुनको लागि आवश्यक पर्ने तŒव हाइड्रोजन सायनाइड (HCN) बनाउँदछ । यो प्रवाह भएको समयमा उच्च तापक्रमका कारण कुनै पनि वस्तुलाई यसले छुँदै पग्ली हाल्दछ । फलाम जस्तो ठोस अवस्थाको धातु पनि पग्लिएर पछि डल्लो अवस्थामा वा ग्याँस अवस्थामा पनि परिणत हुने गर्दछ । यसको अवधि धरै छोटो भए पनि धेरै मात्रामा करेन्टको प्रवाह हुने भएकोले यो मानव जीवन, जीवजन्तु तथा अग्ला बोटविरुवाहरूको लागि खतराजनक मानिन्छ ।
नाटकको चौथो चरण कथामा रसविधान
Authors: लुइटेल Luitel गोविन्दप्रसाद Govindaprasad
Published: November 2024

प्रस्तुत आलेख रसविधानको विश्लेषणमा आधारित छ । रस पूर्वीय साहित्यशास्त्रअन्तर्गतको महŒवपूर्ण सिद्धान्त हो । साहित्यिक रचनाको पठनबाट प्राप्त आनन्द वा भावको आस्वादनलाई साहित्यमा रस भनिन्छ ।  साहित्यमा रसको विशिष्ट प्रयोगबाट पाठकहृदय आह्लादित हुन्छ । यस अध्ययनमा ‘नाटकको चौथो चरण’ कथामा कुन रसको प्रयोग के कसरी भएको छ भन्ने कुराको निरूपण यही रससिद्धान्तका आधारमा गरिएको छ ।  यस अध्ययनमा विवेच्य कथामा रस सामग्रीका रूपमा आएका विभाव, अनुभाव, सञ्चारीभाव र स्थायी भावको बेग्लाबेग्लै विश्लेषण गरी निष्कर्ष प्रस्तुत गरिएको छ । यसका लागि प्राथमिक सामग्रीका रूपमा ‘नाटकको चौथो चरण’ कथालाई लिइएको छ । सामग्री विश्लेषणमा गुणात्मक पद्धतिको अवलम्बन गरिएको छ भने विश्लेषणको ढाँचामा रसविधानका सूचक निर्माण गरी त्यसकै आधारमा विश्लेषण गरिएको छ । विवेच्य कथामा नैनबहादुरकी श्रीमतीको मृत्युको हृदयविदारक घटनाको उचित विन्यासबाट करुण रसलाई परिपाक गराइएको छ । यस कथामा करुण रसको अभिव्यक्ति पाठकहृदयलाई विदारण गर्न सक्षम भएकाले त्यो प्रबल रूपमा आएको छ । विभाव, अनुभाव सञ्चारीभावको उचित संयोजनबाट शोक स्थायीभाव उद्बुद्ध भई करुण रस परिपाक भएकाले रसविधानका दृष्टिले प्रस्तुत कथा महŒवपूर्ण र उत्कृष्ट रहेको निष्कर्ष यस अध्ययनबाट प्राप्त भएको छ
विश्वेश्वरप्रसाद कोइरालाका कथात्मक सङ्कथनको प्रकारता
Authors: न्यौपाने Neupane भुवन  Bhuwan
Published: November 2024

नेपाली कथा लेखनको परम्परामा मनोविश्लेषणात्मक यथार्थवादको प्रवर्तन गर्ने कथाकार विश्वेश्वरप्रसाद कोइरालाले आप्mना कथामा नेपाली सामाजिक सन्दर्भलाई प्रस्तुत गर्दै पात्रको मनस्थितिको विश्लेषण गरेका छन् ।  उनका प्रकाशित छब्बिस ओटा कथामा उच्च, मध्यम र निम्न वर्गीय पात्रको मनोदशाको उद्घाटन गरिएको छ ।  उनले यौन मनोविज्ञानमा आधारित कथा लेख्दा नारी मनोदशाको विश्लेषणमा ज्यादा रुचि राखेका छन् भने यौनेतर विषयमा आधारित कथामा उनले बढी मात्रामा पुरुष पात्रको मनोदशाको उद्घाटनमा केन्द्रित भएका छन् र यस्ता कथामा नेपालको वि.सं. १९९५ देखि २०१९÷२० सम्मका सामाजिक, सांस्कृतिक, राजनैतिक विषय समेटिएका छन् । उनका कथाको आन्तर्यमा निरङ्कुश शासन व्यवस्था, सामन्तवाद, पुरातनवाद र रुढिवादमाथि विरोध तथा विद्रोहको स्वर प्रकट गर्दै स्वतन्त्रता, समानता, नागरिक अधिकार र मानवताका पक्षमा वकालत गरिएको हुँदा पाठेतर सन्दर्भको सघनता पाइन्छ । विषयवस्तुका दृष्टिकोणबाट मात्र होइन कि शिल्पशैलीका दृष्टिकोणबाट पनि परम्परागत कथा लेखनको एकरेखीयता तथा घटनाप्रधानतालाई भङ्ग गर्दै कथाको शिल्प, संरचना र प्रस्तुतीकरणमा आधुनिक ढाँचा वा पद्धतिको प्रयोग कोइरालाका कथामा गरिएको पाइन्छ ।
पर्याशैक्षणिक दृष्टिले माध्यमिक नेपाली भाषापाठ्यपुस्तका चित्रको विश्लेषण
Authors: Khanal Rajendra
Published: November 2024

प्रस्तुत लेखमा माध्यमिक तहका नेपाली पाठ्यपुस्तकमा समाविष्ट चित्रमा प्रविष्ट पर्यावरणीय पक्षको पहिचान गरी तिनको विश्लेषण गरिएको छ । गुणात्मक ढाँचामा आधारित यस लेखमा कक्षा नौ र दशका नेपाली पाठ्यपुस्तकमा समाविष्ट पर्यावरणीय सन्दर्भ रहेका चित्रहरू प्राथमिक स्रोत बनेका छन् भने सम्बद्ध सैद्धान्तिक ग्रन्थ, लेख तथा प्रतिवेदनलाई द्वितीयक स्रोत सामग्रीका रूपमा लिइएको छ । आलोचनात्मक विश्लेषण प्रक्रिया अपनाइएको यस लेखमा निर्दिष्ट पुस्तकमा पर्यावरणीय पक्ष समावेश भएका चित्र मूल तथ्य बनेका छन् । कक्षा नौ र दशमा राखिएका चित्रमध्ये पर्यावरणीय सन्दर्भको सामान्य किसिमले प्रस्तुत भएका जम्मा १४ ओटा चित्र छन् । कक्षा नौमा आठओटा र कक्षा दशमा छओटा चित्रमा पर्यावरणीय सन्दर्भ रहेको देखिन्छ । कक्षा नौमा रहेका उक्त चित्रमध्ये प्रत्यक्षतः पर्याचेत विकास गराउने किसिमका जम्मा दुईओटा मात्र देखिन्छन् । कक्षा दशमा पर्यावरणको सामान्य सङ्केत भएका छओटा चित्रमध्ये पर्याचेत विकास गराउने खालको एउटा चित्र पनि छैन । यो तथ्यबाट उक्त पुस्तकमा राखिएका चित्रहरू पर्याशैक्षणिक दृष्टिले मूल्याङ्कन गर्दा उपयुक्त देखिएनन् किनभने उक्त चित्रबाट पर्याचेत विकास गर्ने अपेक्षा देखिएन । उक्त पाठ्यपुस्तकमा समाविष्ट चित्र पर्यावरणीय सन्तुलन एवम् संरक्षणको सचेततामा केन्द्रित छैनन् । सम्बद्ध विद्यार्थी तथा शिक्षकमा पर्याशैक्षणिक ज्ञान, सुझ तथा व्यवहार विकासका निम्ति उपयोगी नभएको देखिन्छ । समकालीन समयमा पर्यावरणीय सन्तुलन तथा संरक्षणका औपचारिक शिक्षामा पनि तदनुकूलका सामग्री प्रविष्ट गर्नु आवश्यक छ ।
Perspectives of Parents towards the Use of Corporal Punishment for Children
Authors: Niure Dhruba Prasad , Sapkota Madhabi
Published: November 2024

This article intends to identify the perspectives of parents towards the use of corporal punishment for shaping their children's behaviors. To achieve the objective, this research was guided by interpretive paradigm followed by basic qualitative research design. Only 10 parents were chosen by using purposive sampling method to conduct open-ended interview. Document analysis was also used to gather supplementary information required for the study. The study results reveal that though the corporal punishment is legally banned and has negative consequences on children, parents are continuously using it as a disciplinary method to shape their children's behaviors. Nevertheless, there is an increasing recognition of the limitations of punishment and the long-lasting implications of alternative approaches to making sustainable changes in children's behaviors. Almost all parents believe that punishment should be used to a minimal extent by giving more priority to alternative approaches to modify children’s behaviors.
Customer Satisfaction and Brand Loyalty in the Petrol Bike Market: A Study on Young Riders' Preferences and Expectations
Authors: Subedi Sandesh
Published: November 2024

Introduction: Satisfaction is a person's feelings of pleasure or disappointment resulting from a comparison of a product's perceived performance with expectations. As the definition indicates, satisfaction is a function of perceived performance and expectations. If the performance does not meet the customer's expectations, the customer is dissatisfied. If the performance exceeds expectations, the customer is very satisfied or happy. There has been a noticeable shift in the petrol bike market from a buyer's market to a seller's market, with plenty of choice. Players have to operate on various fronts such as pricing, technological product design, productivity, after-sales service, marketing and distribution. In the short term, the market shares of individual producers are sensitive to capacity, product acceptance, prices and competitive pressures from other producers.
Methods: The research approach used is quantitative research approach in which each of the statements and questions have been provided with certain scores. The total of 123 respondents were taken to conduct the research. A structured questionnaire was designed based on five-point Likert scale.
Findings: In terms of gender, the male population (89.4%) was greater than female population (10.6%). In accordance of age, the majority of people where from age group 18-25 (71.5%). According to the collected data (49.6%) of respondents ride their bike daily.
Conclusion: According to the report, petrol bikes are most popular among young people, particularly from manufacturers such as Hero, Honda, Bajaj and KTM. Many users are satisfied with their bikes and would suggest them to others, but they believe they may be improved in terms of speed, fuel efficiency, noise, and lighting. Companies can increase customer satisfaction by enhancing these elements. Focusing on these improvements and marketing to young male riders may help these brands flourish.
Aerodigestive Foreign Bodies: Our Experience
Authors: Vijaykumar Shah Rahul kumar
Published: November 2024

Foreign body ingestion and aspiration is a common cause of morbidity and mortality, usually occurs in children. A detailed history and physical examination with a high index of suspicion, despite negative imaging are required. Often, a diagnostic endoscopy may be required to definitively investigate the upper aerodigestive tract to rule out foreign body in equivocal findings. Non caustic oesophageal foreign bodies can be observed for a short period of time while Airway foreign bodies require immediate removal in the operating room. A team-based approach with coordination between the trained anaesthetist, surgeon, and operating room staff is required during this foreign body management.
Primary Squamous Cell Carcinoma of the Parotid Gland: A Case Report and Literature Review
Authors: Marques Gomes Pedro
Published: November 2024

Salivary gland tumors represent about 3% of all head and neck tumors, with the vast majority occurring in the parotid gland. Squamous cell carcinomas rarely are primary in the salivary glands, representing less than 1% of all parotid malignancies. A 76-year-old man was referred to Otorhinolaryngology due to a right preauricular swelling that had progressively increased in size. Physical examination revealed a painful, firm lesion in the right parotid region, with right peripheral facial palsy. Remaining ENT examination was normal. The biopsy showed a squamous cell carcinoma. CT scan showed a heterogeneous nodule, with peripheral contrast enhancement, in the deep lobe of the right parotid gland. No cleavage plane with the right masseter. No bone or perineural invasion and no signs of ganglionic or organic involvement. No lesions in another areas. Primary parotid squamous cell carcinoma is a rare, aggressive, high-grade salivary gland neoplasm, with worse prognosis than conventional ENT squamous cell carcinoma.
Caring a patient with brain injury experiencing increased intracranial pressure: A case report
Authors: Ridwan Ridwan , Nur Rezeki , Karim Kasmawati
Published: November 2024

Traumatic Brain Injury (TBI) is a significant contributor to mortality and a critical global health concern. Elevated intracranial pressure (ICP) appears to be an acute and potentially fatal complication that requires increased focus from clinical nurses within hospital settings. It is critical to manage patients with TBI who also have elevated ICP to prevent an ICP extremity. This research aimed to assess the efficacy of SIKI in treating patients with TBI. This study presents the case of a 12-year-old child who sustained an epidural haemorrhage due to a traffic accident and had a mild to moderate traumatic brain injury. Nursing care is administered through monitoring interventions and ICP improvement management. Due to the clinical advantages, healthcare industry policymakers should recommend using SIKI during TBI treatment.
Keywords: Brain injury; nursing care; intracranial pressure; nursing intervention; hospital care
A clinical review of early assessment for congenital hypothyroidism in newborns
Authors: Wardani Septi , Sulistyono Dwi
Published: November 2024

Congenital hypothyroidism is a critical factor associated with stunting, as thyroid hormone deficiencies can impair growth starting in utero. Children with thyroid disorders, including conditions like hypoparathyroidism, often experience growth retardation due to congenital abnormalities and growth hormone deficiencies. For neonates, a lack of thyroid hormones can lead to long-term impacts, such as physical and mental disabilities, neurological disorders, and stunted growth. Early detection of congenital hypothyroidism is, therefore, essential and is typically part of newborn screening aimed at identifying congenital abnormalities. Implementing early screening protocols can diagnose and treat congenital hypothyroidism promptly, mitigating risks such as stunting and enabling better health outcomes for children. This literature review examines methods of early detection for congenital hypothyroidism across various global contexts. Three databases—PubMed, ScienceDirect, and Google Scholar—were searched using a systematic literature review approach, yielding five eligible studies with a combined study population of 920.441 newborns. These studies involved screenings for T4, TSH, 17-OHP, and G-6-PD, identifying hypothyroidism in 2.530 (27%) cases. Screening involved blood samples taken from the umbilical cord or heel within 48 to 72 hours after birth. Understanding early detection procedures for congenital hypothyroidism is essential for nurses, as it enables them to engage in early intervention and provide effective nursing care for affected infants. Early involvement can help prevent the adverse, long-term effects associated with congenital hypothyroidism, improving quality of life and supporting healthy growth trajectories for children at risk.
Keywords: Congenital hypothyroidism; literature review; nursing assessment; paediatric nursing; prevention
Epidemiological Manifestations of Purulent Bacterial Meningitis in the Russian Federation
Authors: Davydenko M. A. , Churilova N. S. , Koroleva I. S.
Published: November 2024

Relevance. Although meningitis is largely preventable, it still causes hundreds of thousands of deaths worldwide each year. Significant progress has been made in reducing meningitis mortality over the past three decades. The incidence of meningococcal, pneumococcal, and Haemophilus influenzae type b meningitis has declined due to the introduction of vaccination into national immunization programs in countries around the world. Aim. To determine the epidemiological manifestations of purulent bacterial meningitis (GBM) in the Russian Federation (RF) in 2023. Materials and methods. An in-depth personalized system for recording purulent bacterial meningitis cases has been established at the Russian Reference Center for Bacterial Meningitis Monitoring. Since 2010, all territories of the Russian Federation have been included in the monitoring system. In 2023, the Reference Center received information on 1,837 cases of purulent bacterial meningitis. The paper uses a descriptive and evaluative epidemiological method: retrospective analysis. Results and discussion. The incidence of GBM in the Russian Federation over a fourteen-year observation period has a downward trend. Meningococcus, pneumococcus and Haemophilus influenzae are the causes of 85% of GBM cases in the Russian Federation, while the infections they cause are potentially vaccine-preventable. Meningococcus continues to occupy a leading position in the etiology of GBM in the Russian Federation, causing 50% of all laboratory-confirmed cases. Despite a slight decrease in the incidence of meningococcal infection in 2023, its increase in the age group at risk, children under 5 years of age, by 39% was noted. In the serogroup characteristics of meningococcus, for the first time in the studied period, the predominance of meningococcus serogroup W was revealed. In 2023, the highest mortality rate from meningococcal infection was noted – 21%. The incidence rate of pneumococcal meningitis in the age group at risk, children under 5 years old, increased to 28% in 2023, and categories of adults are defined as risk groups for mortality. The incidence of meningitis caused by Haemophilus influenzae among children under 5 years old decreased by 44%, and all cases of death, with the exception of one, were noted in this age group. Conclusion. The data obtained make it possible to track the etiology of GBM, age groups and risk areas, which can serve as a basis for developing tactics to combat the disease with priority use of vaccines.
Biosafety and Genomic Epidemiological Surveillance
Authors: Akimkin V. G. , Semenenko T. A. , Khafizov K. F. , Ugleva S. V. , Dubodelov D. V. , Sverdlov E. D. , Cherkashina A. S. , Gasanov G. A. , Nadtoka M. I. , Rumyantseva N. P. , Mikhailova Yu. V. , Shelenkov A. A. , Esman A. S. , Alekseenko I. V. , Kondratyeva L. G. , Beregovykh R. M.
Published: November 2024

The problem of biological safety is extremely relevant today for all countries of the world because of the real and potential threats caused by biological agents that are dangerous to public health and the environment. Modern microorganisms are becoming increasingly aggressive towards humans, as clearly demonstrated by the COVID-19 pandemic, which has affected all aspects of people's lives and exposed the vulnerability of the healthcare system. According to the Decree of the President of the Russian Federation «On the Fundamentals of the State policy of the Russian Federation in the field of chemical and biological safety for the period up to 2025 and beyond» and the Federal Law «On Biological Safety in the Russian Federation», the main objectives of state policy are to reduce the risks of negative effects of biological factors on the population and the environment. Antimicrobial resistance, the emergence of new infections and the overcoming of interspecific barriers by microorganisms are of particular concern. Infectious disease agents with epidemic potential, such as Ebola, Zika, Marburg, Lassa, MERS-CoV and SARS-CoV viruses, continue to pose a high threat. To counteract new biological threats, Russia has created a scientific concept of future biosafety, focusing on the development of genomic epidemiological surveillance, digital transformation and mobile technologies. Effective management of epidemic processes requires constant monitoring of genetic changes in infectious agents and prompt response to new threats, which allows the VGARus platform created in Russia to monitor virus mutations. Thus, genomic epidemiological surveillance is becoming a key element of ensuring biological safety and scientific and technological development in Russia.
Neutralizing Antibody Spectrum in COVID-19 Patients who Became Ill During the Circulation of Different SARS-CoV-2 Variants
Authors: Pylaeva S. K. , Kozlovskaya L. I. , Erovichenkov A. A. , Sirazova D. I. , Shustova E. Y. , Artamonova E. A. , Sinyugina A. A. , Gordeychuk I. V. , Troshyanskiy D. V. , Kosareva E. V. , Solodovnikova O. N. , Kogotyzhev R. K. , Berestovskaia A. U. , Tyurin I. N. , Protsenko D. N. , Ishmukhametov A. A.
Published: November 2024

SARS-CoV-2 has been actively circulating in the human population since late 2019. During this time, the virus acquired more than 140 nucleotide mutations and 20 deletions per genome from the original variant identified in Wuhan. As the virus circulates, the proportion of re-infected individuals increases, but it is unclear how well neutralizing antibodies formed by infection with early variants neutralize the new Omicron variant lines. We analyzed the neutralizing activity of 286 sera from 286 adult patients with COVID-19 in 2020-2021, during the circulation of the prototypical lines and the Delta variant of SARS-CoV-2, against strains of the original lines and the Omicron ВА.1 and ХВВ.1.9. 2. About 10% of the sera of people who overexperienced COVID-19 while the prototypical strains were circulating and about 50% of people who overexperienced it while the Delta variant was circulating contain antibodies that neutralize Omicron ХВВ.1.9 was circulating in 2023. Thus, a fraction of people, regardless of age, who became infected in 2020-2021 have an antibody spectrum capable of neutralizing current and possibly related SARS-CoV-2 variants that will emerge in the near future. However, no strong positive correlation was found between IgG levels to RBD and NAТ titers to SARS-CoV-2 (R < 0.5), which may complicate serologic diagnosis of COVID-19 and lead to inappropriate assessment of human protection and the presence of an immune layer to SARS-CoV-2 in population-based studies.
Efecto del calentamiento global en la franja de condensación atmosférica en la península de Yucatán
Authors: Castelán Lorenzo Mario
Published: November 2024

El calentamiento global tiene varios efectos en el comportamiento de los fenómenos atmosféricos, uno de ellos es la afectación en la condensación de humedad atmosférica. El objetivo de este trabajo fue determinar la franja de condensación en tres localidades de la Península de Yucatán, México, utilizando datos climatológicos correspondientes a las décadas de 1980 y 2010. Se utilizaron los parámetros temperatura de bulbo seco y bulbo húmedo para calcular la altitud de condensación empleando tablas psicrométricas. Los resultados indican un aumento en la temperatura media, lo cual evidencia un cambio en la altitud de condensación. En Mérida, Yucatán, para el primer periodo la franja de condensación oscilaba entre 308 y 862 m de altitud con una temperatura de 25.2°C. Con un incremento de 1.1°C, esta franja se desplazó a un rango de 523 a 1246 m. En Valladolid, Yucatán, la franja de condensación se situaba entre 615 y 1185 m con una temperatura de 26.6°C y con un aumento de 0.6°C se extendió a 646-1400 m. Finalmente, en Chetumal, Quintana Roo, con una temperatura de 27°C, la franja de condensación iba de 523 a 1092 m y con un incremento de 0.3°C se desplazó a 569-1154 m. Estos cambios en la altitud de condensación podrían afectar el ciclo hidrológico, reduciendo la condensación de humedad atmosférica que potencialmente recargaría los ríos atmosféricos. Esto subraya la necesidad de reforestar las áreas de bosques y selvas para mitigar los efectos ambientales negativos provocados por el desequilibrio climático.
Detection of Traffic Anomalies Based on Their Frame Wavelet Transformations Processing
Authors: Zhdanova I. M. , Dvornikov S. S. , Dvornikov S. V.
Published: November 2024

Relevance. The active transition to a massive digital infrastructure based on Internet of Things (IoT) technology has brought telecommunications networks to the level of dominant information resources. The one-time increase in the number of existing Internet services is inextricably linked to the growing variety of network anomalies on telecommunications equipment. In turn, existing methods of detecting network threats do not allow timely assessment of network traffic, which is characterized by a large number of parameters, and the detected anomalies from external interference do not have pronounced patterns.

The purpose of the study is to increase the efficiency of detecting traffic anomalies based on the results of processing its frame wavelet transform. The scientific task is to develop scientific and methodological approaches that allow effective analysis and timely detection of anomalies in network traffic. A comparative review of search methods for detecting network traffic anomalies, algorithms for detecting uncontrolled anomalies, traffic analysis methods based on local emission factor, binary trees, optical emission spectroscopy.

Decision. The results of the study of the possibility of detecting anomalies in the bitstream traffic based on the results of its multiple-variable transformation in the Haar wavelet basis are considered. The choice for further processing of the coefficients of the traffic decomposition matrix along the time shift variable is justified. It is proved that multiple-scale transformations not only increase the structural differences in traffic, but also open up the possibility of localization of anomalies that caused these differences.

The scientific novelty of the work is determined by the author's approach to detecting network traffic anomalies during the transition from the direct representation of a signal in the form of its discrete samples to coefficients formed from the matrices of its wavelet transformations, and, as a result, increasing its contrast with other signals with a similar structure.

Theoretical significance. The necessity and sufficiency of using wavelet coefficients instead of time samples of signals in the basis of the parent wavelet from the matrix of the generated frame is proved. The relationship between the Hurst indicators and the coefficients of the cross-correlation functions has been established.

Practical significance. The results obtained in the work, in the future, can be used in the construction of models for evaluating network traffic in conditions of deliberate, as well as methods for searching and synthesizing effective methods of protection against them.
SOSIALISASI PEMILIHAN UMUM (PEMILU KEPADA PEMILIH PEMULA DI KELUARAHAN MARGASARI KECAMATAN BUAH BATU KOTA BANDUNG
Authors: Fidowaty Tatik
Published: November 2024

Tujuan PkM ini adalah memberikan pendidikan politik tentang pemilu kepada pemilih pemula yang baru pertama kali akan memberikan hak suara dalam pemilihan umum, selain itu juga untuk meningkatkan partisipasi pemuda/pemudi/masyarakat dalam pemilihan umum serta memberikan pengetahuan kepada pemilih pemula bagaimana cara memilih pemimpin yang baik dan berkualitas dalam pemilihan umum baik pemilihan presiden, pemilihan kepala daerah, pemilihan anggota DPR, DPD dan DPRD Kota Bandung. Pemilihan umum merupakan pesta demokrasi rakyat karena pada hari ini rakyat bebas untuk memilih pemimpin yang mereka inginkan, one man one vote atau sering diteriakan kata 5 menit untuk 5 tahun. Pemilih pemula merupakan pemilih yang baru mendapatkan KTP (kartu tanda penduduk) sehingga baru pertama kali akan mengikuti pemilihan umum sehingga perlu diberikan pendidikan politik terkait pelaksanaan pemilu supaya mampu memilih pemimpin yang baik dan amanah. Untuk metode pelaksanaan PkM dilakukan dengan cara memberikan pendidikan dan pengetahuan tentang pemilu melalui sosialisasi kepada pemilih pemula. Setiap RW mengirimkan 2 orang pemilih pemula untuk mengikuti sosialisasi pemilu. Peserta yang hadir cukup antusias mendengarkan pemaparan materi dari narasumber, mereka juga banyak bertanya karena masih banyak kebingungan yang mereka rasakan terutama saat kampanye. Hoax bertebaran seperti jamur di musim hujan, untuk itu pemilih pemula harus mampu memilih dan memilah berbagai macam informasi yang beredar. Informasi harus berasal dari sumber yang terpercaya atau resmi seperti KPU (komisi pemilihan umum) atau lembaga resmi yang lainnya.
Peningkatan Produktivitas dan Profitabilitas Kelompok Tani Cabai Di Desa Karanganyar Kecamatan Poncokusumo Kabupaten Malang
Authors: Jatmiko Andriyan Rizki , Pamuji Fandi Yulian , Agus Suryanto  , Hudan Eka Rosyadi  , Firnanda Al-Islama Achyunda Putra
Published: November 2024

Kelompok Tani Dewi Sri 2 awal didirikan pada tahun 2010 melalui musyawarah pengurus desa Karanganyar Kecamatan Poncokusumo Kabupaten Malang. Saat ini, kelompok Tani Dewi Sri 2 terdiri dari 15 petani dan ketua kelompok bernama Bapak Purwanto. Tujuan mulanya kelompok tani ini didirikan karena warga desa Karanganyar Kecamatan Poncokusumo mayoritasnya adalah petani dan pertanian adalah mata pencaharian utama. Salah satu penyebab utamanya adalah musim hujan di aspek produksi. Pada musim ini menimbulkan beberapa masalah, antara lain munculnya hama dan overwatering (menyebabkan tanaman layu). Masalah serangan hama berupa Tungau, kedua adalah virus, ketiga adalah hama jenis ulat dan yang terahir adalah Lalat Buah. Alat perangkap hama yang dirancang bekerja dengan baik karena dapat melindungi tanaman dari hujan berlebihan dan memastikan pertumbuhan yang optimal. Alat perangkap hama yang dirancang bekerja dengan baik karena dapat melindungi tanaman dari serangan hama yang massal, terutama oleh hama lalat buah, menjadi ancaman terbesar bagi petani saat masa panen dan memastikan pertumbuhan yang optimal. Untuk menjaga keberlanjutan program, tim pengabdian akan menyediakan modul atau materi dari semua program yang telah dilakukan. Selain itu, akan disediakan modul perawatan alat perangkap hama beserta informasi mengenai bahan-bahan yang dapat digunakan pada alat tersebut.
PENGARUH PERTUMBUHAN PEMUKIMAN TERHADAP AKTIVITAS PEREKONOMIAN DI KELURAHAN KOYA BARAT
Authors: Huwae Pricilia , Ana Rusim Dewi , Rante Harmonis
Published: November 2024

This research aims to identify the factors influencing the growth of settlements and economic activities inKoya Barat Village, Muara Tami District, and the efforts made in the growth of settlements and economic activitiesin Koya Barat Village, Muara Tami District. The quantitative research method and data collection techniquesinvolve questionnaires and documentation. The data analysis uses simple linear regression. The results of theresearch indicate that the factors influencing the growth of settlements and economic activities in Koya BaratVillage, Muara Tami District, show that the level of settlement growth in Koya Barat Village, Muara Tami District,is categorized as high, with 65 respondents or 65%. This includes several factors such as the type of physicalbuilding, building/occupant type, wall type, roof type, ceiling, floor type, door, sanitation, window, ventilation,and ridge. The economic level of the community with a very high economic level is 33 respondents or 33%, anda high economic level is 31 respondents or 31%, which means that the economic level of the community in KoyaBarat Village, Muara Tami District is high, including education level, occupation/livelihood, and householdincome. The efforts made in the growth of settlements and economic activities in Koya Barat Village, Muara TamiDistrict, indicate a significant influence of settlement growth on the economy in Koya Barat Village, Muara TamiDistrict, which means that if settlement growth increases, economic activities will also experience a significantincrease.
Involvement of Academic Staff in the Practice of Professional Development
Authors: Efimova G. Z.
Published: November 2024

The article explores the level of involvement of scientific and pedagogical professionals in various social activities for professional development compared to other employee groups. It argues that obtaining additional professional training can be a valuable tool for career growth. The author sees professional development as an integral part of academic growth for scientific and educational workers, along with personal and career development. The findings are based on a combination of theoretical and empirical research conducted by domestic and international scholars, as well as official statistical data and the results of an original sociological study. The study involved a questionnaire survey of scientific and educational professionals (n = 223), as well as other employee groups (n = 833), in the Tyumen and Sverdlovsk regions. As a result, it was found that scientific and pedagogical workers are more likely to engage in professional development activities compared to other categories of the employed population. Continuing professional education programs appear to be the most common form of professional growth. Due to their specialized activities, academic staff tend to develop digital skills more often, while other groups develop personal skills to a greater degree. Based on the level of involvement in professional development, we identified five groups of respondents: “active and engaged”, “achieving the desired level or feeling disappointed”, “questioning or confused”, “recognizing the importance of professional development”, and “rejecting professional development”. The theoretical and empirical findings led to the development of potential strategies to enhance the engagement of scientific and educational professionals in ongoing skill development and acquisition of new competencies. This article is aimed at university management responsible for professional development of academic staff. The findings presented here may have practical implications for the development of personnel strategies at universities with the goal of increasing human capital and professional competence among academic staff, as well as motivating them to engage in continuous learning. The results of this study could be beneficial for participants in the academic community, as well as for specialists involved in developing educational programs and planning the future of universities strategically. The material presented in this paper is relevant not only for academic staff, but also for graduate students who are focused on their continuous professional growth within the academic sector.