bluuebunny/crossref_metadata_2025 huggingface dataset:
Switching of primary health care providers among self-paid health insurance participants in Denpasar, Bali, Indonesia
Authors: Wasita Rai Riska Resty , Nopiyani Ni Made Sri , Januraga Pande Putu
Published: April 2019

Background and purposes:Â The number of Jaminan Kesehatan Nasional or National Health Insurance (NHI) participants switching their fasilitas kesehatan tingkat pertama or primary healthcare (PHC) providers is increasing and dominatedÂ by self-paid participants. This switching could result in unequal distribution of NHI participants and amount of capitation among PHC providers.Â This studyÂ aims to explore the reasons underlying self-paid NHI participants to switch PHC providers.Method:Â ThisÂ is a qualitativeÂ study using in-depth interviewsÂ with a total of 14Â participants recruited purposively, consisted of ten NHI self-paid participants who had switched andÂ four participants whoÂ intend to switch PHC providers.Â  Semi-structured interview guide incorporated the aspects of ConsumerÂ SwitchingÂ BehaviorÂ Model. The interviews explored four aspects of participantsâ€™ intention to switch providers including inconvenience, service encounter failures, core health service failures, and attraction by competitor.Â The verbatim transcripts were analyzed thematically.Results: Self-paid NHI participants in this study cited four main reasons for switching PHC providers. The first reason is inconvenience in accessing PHC providerâ€™s services due to long distance, long waiting times, unsuitable opening hours, and poor facilities. Secondly, patients cited the poorÂ interaction between healthcare providers and patients specifically, lack of attentiveness, poor eye contact, poor delivery of health information, lack of consideration of patientsâ€™ opinions, and lack of responsivenessÂ to patientsâ€™Â complaints. The third reason is core healthcare service failures, includingÂ hastyÂ examinations, inaccurate diagnoses, andÂ errors in prescribing medication. Finally, informants reported that they wished to switch PHC providers due to the attractiveness of other providers, in terms of facilities availability, professionalism of healthcare providers, additional health programs, and ease of access to fasilitas kesehatan rujukan tingkat lanjut or referral healthcare facilities.Conclusion:Â Self-paid NHI participantsâ€™ intention to switch PHC providers was mainly attributed to the perceived poor healthcare quality of the provider and superiority of the others.Â Continuous quality improvement should be undertaken by PHC providers to increase participantsâ€™ loyalty.
The first Vietnam School of Earth Observation: Atmospheric Remote Sensing and Molecular Spectroscopy
Authors: Ha Tran , Cuisset Arnaud , Payan Sébastien , Schwell Martin , Té Yao , Tomasini Linda , Héraud Yannick Giraud-
Published: April 2019

In this review paper, we give an introduction to molecular spectroscopy and its relation to atmospheric remote sensing and examples of recent developments in spectroscopic experimental techniques and modelling. Atmospheric retrieval techniques, based on radiative transfer theories and molecular spectroscopy as well as some atmospheric remote sensing missions using spectroscopic techniques are presented.
Social policy: From axiology to social acceptance
Authors: Laurisz Norbert
Published: April 2019

The purpose of this article is to place social policy in the axiological dimension, as well as to present the influence of axiology and social acceptance on the conceptual and real shape of social policy. The article presents selected elements of the process of shaping the axiological dimension of social policy and outlines the specificity of this process in the case of social activities of the state. It justifies shaping social policy based on market factors and directing changes towards the multi-sectoral character of this policy and social economy.
Bone, Periodontal and Dental Pulp Regeneration in Dentistry: A Systematic Scoping Review
Authors: Chisini Luiz Alexandre , Conde Marcus Cristian Muniz , Grazioli Guillermo , Martin Alissa Schmidt San , Carvalho Rodrigo Varella de , Sartori Letícia Regina Morello , Demarco Flávio Fernando
Published: April 2019

Abstract The aim of presented systematic scoping review was to investigate the actual and future clinical possibilities of regenerative therapies and their ability to regenerate bone, periodontal and pulp with histological confirmation of the nature of formed tissue. Electronic search was conducted using a combination between Keywords and MeSH terms in PubMed, Scopus, ISI-Web of Science and Cochrane library databases up to January 2016. Two reviewers conducted independently the papers judgment. Screened studies were read following the predetermined inclusion criteria. The included studies were evaluated in accordance with Arksey and O’Malley’s modified framework. From 1349 papers, 168 completed inclusion criteria. Several characterized and uncharacterized cells used in Cell Therapy have provided bone regeneration, demonstrating bone gain in quantity and quality, even as accelerators for bone and periodontal regeneration. Synthetic and natural scaffolds presented good cell maintenance, however polyglycolid-polylactid presented faster resorption and consequently poor bone gain. The Growth Factor-Mediated Therapy was able to regenerate bone and all features of a periodontal tissue in bone defects. Teeth submitted to Revascularization presented an increase of length and width of root canal. However, formed tissues not seem able to deposit dentin, characterizing a repaired tissue. Both PRP and PRF presented benefits when applied in regenerative therapies as natural scaffolds. Therefore, most studies that applied regenerative therapies have provided promising results being possible to regenerate bone and periodontal tissue with histological confirmation. However, pulp regeneration was not reported. These results should be interpreted with caution due to the short follow-up periods.
Effects of an Auxin and a brassinosteroid on physical, chemical and biochemical attributes of ‘Galaxy’ apples
Authors: Ramos Ângela Preza , Zanardi Aquidauana Miqueloto , Amarante Cassandro Vidal Talamini do , Steffens Cristiano André , Pereira-Netto Adaucto Bellarmino
Published: April 2019

ABSTRACT: The aim of this study was to study the effect of the auxin naphthalene acetic acid (NAA) and the brassinosteroid 28-homocastasterone (28-HCS) applied every 15 days (harvest 2015/16) or every 21 days (harvest 2016/17) after full bloom, on the physical, chemical and biochemical attributes of the ‘Galaxy’ apples. The study was performed at a commercial orchard at Vacaria county, Rio Grande do Sul State, Brazil. The following treatments were applied: water (control), NAA (0.1%), 28-HCS (10‒6 M) and NAA (0.1%) + 28-HCS (10‒6 M). For this purpose, 300 μL of the plant growth regulator solutions were applied to the fruit peduncles. Fruits treated with NAA every 21 days presented higher starch-iodine index and lower total soluble solids (TSS), titratable acidity (TA), lightness index (L) and hue angle (h°) than 28-HCS-treated fruits. Fruits treated every 15 days with NAA presented reduced skin rupture force (SRF), total antioxidant activities (TAA) of the skin and flesh, and hydrogen peroxide content compared to the control fruits. In addition, NAA application every 15 and 21 days resulted in increased anthocyanin content in the skin. Application of NAA + 28-HCS reduced superoxide dismutase activity. 28-HCS applications increased TSS, color attributes (C and h°) of the skin, total antioxidant activity of the skin and flesh and peroxidase activity compared to control fruits. These results are expected to help to understand how plant growth regulators affect apple quality. In addition, results described here are also expected to help on the development of strategies to reduce post harvest losses and to increase fruit shelf life.
Phytochemical screening and antimicrobial activity testing of crude hydroalcoholic extract from leaves of Sphagneticola trilobata (Asteraceae)
Authors: Leite Ana Greice Borba , Farias Eulina Tereza Nery , Oliveira Ana Paula de , Abreu Ruan Emmanuell Franco de , Costa Mateus Matiuzzi da , Almeida Jackson Roberto Guedes da Silva , Estevão Lígia Reis de Moura , Evêncio-Neto Joaquim
Published: April 2019

ABSTRACT: This study aimed to perform phytochemical analysis and to test the antimicrobial activity of the crude hydroalcoholic extract obtained from the leaves of Sphagneticola trilobata. Classes of secondary metabolites present in the extract were identified through phytochemical screening using analytical thin-layer chromatography. Antimicrobial activity was evaluated by testing cultures of Staphylococcus aureus, S. epidermidis, Staphylococcus spp., Escherichia coli, Serratia marcescens, Enterococcus faecalis, Pseudomonas aeruginosa, Salmonella Typhimurium, and Klebsiella pneumoniae isolated from human skin and those of Staphylococcus spp. isolated from dog skin using the broth microdilution method. In the phytochemical screening, classes of anthracenic derivatives and mono-, sesqui-, and diterpenes were identified. Colorimetric analysis showed total phenol and total flavonoid contents of 21.7 ± 0.009 mg of gallic acid equivalents per gram of sample and 0.23 ± 0.005 mg of catechin equivalents per gram of sample, respectively. Microbiological analysis revealed that the hydroalcoholic extract of S. trilobata exhibited antimicrobial activity against cultures of Staphylococcus spp., E. coli, S. marcescens, and E. faecalis isolated from human skin and those of Staphylococcus spp. isolated from dog skin. Thus, crude hydroalcoholic extract of leaves of S. trilobata contained flavonoids and terpenoids as secondary metabolites, which contributed to its antimicrobial activity against skin bacteria isolated from different sources.
Downregulation of lncrna uca1 as a diagnostic and prognostic biomarker for ovarian endometriosis
Authors: Huang Huan , Zhu Zhengyan , Song Yu
Published: April 2019

SUMMARY OBJECTIVE: Ovarian endometriosis seriously affects the quality of life of females, and long non-coding RNA lncRNA urothelial carcinoma-associated 1 (UCA1) plays pivotal roles in the pathogenesis of various ovarian diseases. However, the involvement of lncRNA UCA1 in ovarian endometriosis remains unknown to date. Therefore, the present study aims to study the role of UCA1 in ovarian endometriosis. METHODS: A total of 98 patients with ovarian endometriosis and 28 healthy females were included. The expression of lncRNA UCA1 in ectopic and eutopic endometrium tissues of ovarian endometriosis patients and controls was detected using qRT-PCR. A ROC curve analysis was performed to evaluate the diagnostic values of serum lncRNA UCA1 for ovarian endometriosis. Patients were followed up for 2 years after discharge, and the recurrence of ovarian endometriosis was recorded. RESULTS: The expression level of lncRNA UCA1 was significantly higher in ectopic endometrium tissues than in paired eutopic endometrium tissues for most of the patients. The serum lncRNA UCA1 level showed no significant correlations with either patients’ age or living habits. After the treatment, the serum lncRNA UCA1 level increased, and serum levels of lncRNA UCA1 on the day of discharge were significantly lower in patients with recurrence than those in patients without recurrence. Conclusion: The downregulation of lncRNA UCA1 is involved in the pathogenesis of ovarian endometriosis and may serve as a promising diagnostic and prognostic biomarker for the disease.
An anterior neurovascular interval approach to coronal shear fractures of the distal humerus: a prospective clinical study with short- to mid-term follow-up
Authors: Yang Xiao-Hua , Wei Chen , Li Guo-Ping , Wang Jian-Ji , Zhao Hai-Tao , Shi Li-Tao , Cao Xiang-Yu , Zhang Ying-Ze
Published: April 2019

SUMMARY OBJECT: To explore the treatment effect of the anterior medial neurovascular interval approach to coronal shear fractures of the distal humerus. METHODS: This prospective study included two female patients who were 30-64 years old, with a mean age of 47 years. Fractures were caused by falling from a bicycle. The time between the injury and operation was 1-2 days, with a mean time interval of 1.5 days. Two patients with coronal shear fracture of the distal humerus were treated with open reduction and internal fixation using anterior neurovascular interval approach. RESULTS: There were no intraoperative and postoperative neurological and vascular complications or infections, and the fracture was united. At 12 months after the surgery, the patient returned to work without pain, and with a normal range of motion for elbow and forearm rotation. The X-rays revealed excellent fracture union, no signs of heterotopic ossification, and no traumatic arthritis. According to Mayo's evaluation standards for elbow function, a score of 100 is excellent. CONCLUSIONS: The application of the anterior neurovascular interval approach of the elbow in the treatment of shear fracture of the articular surface of the distal humerus, particularly the trochlea of the humerus, can reduce the stripping of the soft tissue.
Investigation of the effect of the virtual reality application on experimental pain severity in healthy
Authors: Karaman Dilek , Erol Funda , Yılmaz Dilek , Dikmen Yurdanur
Published: April 2019

SUMMARY OBJECTIVE: This study aimed to investigate the effect of virtual reality application on experimental ischemic pain created with a blood pressure instrument in healthy volunteers. METHODS: The research sample consisted of 172 volunteer adult students who conformed to the inclusion criteria. These individuals were assigned into an experimental (n=86) and a control group (n=86) by a simple randomization method. All individuals in the experimental and control groups wereexperimentally subjected to pain for two minutes by applying 260 mmHg of pressure 3-4 cm above the antecubital region of the left arm with an aneroid adult-type blood pressure instrument. During the procedure, the volunteers in the experimental group watched virtual reality images, while those in the control group received no intervention. Immediately after the procedure, the pain levels of the individuals in both groups were assessed with a Visual Analog Scale (VAS). RESULTS: We found that the mean pain score of the individuals in the experimental group was 2.62±1.82, and that of individuals in the control group was 5.75±1.65. Results of the statistical analysis showed a statistically significant difference between the mean pain scores of the individuals in the experimental and control groups (p<0.001). CONCLUSION: This study found that the use of virtual reality was effective in reducing the level of pain in healthy individuals. This method used a smartphone with widespread availability and ease of transportation, which can be used by health professionals as a non-pharmacological method in the management of pain.
Rational use of diagnostic tests for clinical decision making
Authors: Buehler Anna Maria , Ascef Bruna de Oliveira , Oliveira Júnior Haliton Alves de , Ferri Cleusa Pinheiro , Fernandes Jefferson Gomes
Published: April 2019

SUMMARY OBJECTIVE: To assist clinicians to make adequate interpretation of scientific evidence from studies that evaluate diagnostic tests in order to allow their rational use in clinical practice. METHODS: This is a narrative review focused on the main concepts, study designs, the adequate interpretation of the diagnostic accuracy data, and making inferences about the impact of diagnostic testing in clinical practice. RESULTS: Most of the literature that evaluates the performance of diagnostic tests uses cross-sectional design. Randomized clinical trials, in which diagnostic strategies are compared, are scarce. Cross-sectional studies measure diagnostic accuracy outcomes that are considered indirect and insufficient to define the real benefit for patients. Among the accuracy outcomes, the positive and negative likelihood ratios are the most useful for clinical management. Variations in the study's cross-sectional design, which may add bias to the results, as well as other domains that contribute to decreasing the reliability of the findings, are discussed, as well as how to extrapolate such accuracy findings on impact and consequences considered important for the patient. Aspects of costs, time to obtain results, patients’ preferences and values should preferably be considered in decision making. CONCLUSION: Knowing the methodology of diagnostic accuracy studies is fundamental, but not sufficient, for the rational use of diagnostic tests. There is a need to balance the desirable and undesirable consequences of tests results for the patients in order to favor a rational decision-making approach about which tests should be recommended in clinical practice.
Digital version of the Rapid Automatized Naming (RAN): a contribution to early detection of reading problems in children
Authors: Silva Junior Davino , Cidrim Luciana , Roazzi Antonio , Madeiro Francisco
Published: April 2019

ABSTRACT Purpose: to present a digital version of the Rapid Automatized Naming (RAN) test, designed to be used as an auxiliary tool for early detection of reading problems in children. Methods: the application was designed to provide resources, such as: a) registration; b) information security with the online authentication system - individuals are only seen by the person who registered them and, c) history of the results. In order to know the impressions of speech therapists and professionals of children’s education area about this digital version of RAN test, a public opinion survey was conducted with unidentified participants by Google Forms. Results: the application has an automatic speech recognition and allows registering and accessing the history of the application, including statistical evaluation of the results. The application features a responsive interface that adapts to the dimensions of the mobile device with soft colors, and offers a variety of text font options. The images of the objects of the digital version were elaborated by a designer. Conclusion: the application presents itself as a useful digital tool that assists professionals to evaluate, early, children with reading difficulties, highlighting the following elements: exclusive and appropriate images to children’s universe and the function of storing the results of users tested.
FROM JOURNALISM TO CULTURAL SOCIOLOGY (AND BACK VIA PARSONS). AN INTERVIEW WITH JEFFREY ALEXANDER
Authors: Vandenberghe Frédéric
Published: April 2019

Abstract Along with a general introduction to Jeffrey Alexander’s sociology, in which I comment on some of the main lines taken by his sociological output over the years (social theory and metatheory, neofunctionalism, cultural sociology and the political sociology of civil society), I present here an unpublished interview with the author, conducted in October 2014 in Rio de Janeiro. During this interview, we talked about various aspects of his personal and intellectual trajectory, highlighting especially continuities and discontinuities over his theoretical journey, from the revisions of the classics of sociology to his more recent formulations on the civil sphere, passing through the place of the Parsonian legacy in his work.
A DÍVIDA GALOPANTE: A ECONOMIA DAS APOSTAS E OS SIGNIFICADOS DOS USOS DO DINHEIRO NO TURFE
Authors: Labronici Rômulo Bulgarelli
Published: April 2019

Resumo Neste trabalho discuto a imbricada relação entre o dinheiro e as apostas no turfe produzindo uma economia específica de trocas entre seus jogadores. Proponho discutir o que está efetivamente sendo jogado. A primeira imagem que vem à cabeça é a de que, no jogo, apostam-se bens materiais, mais especificamente dinheiro. Nas casas de jogo, entretanto, essa associação se dá a partir da relação de uma economia do crédito circulante com base em prestígios individuais que estrutura e molda as relações instituídas. Uma economia relacionada com uma atividade que não deve ser entendida como um fim em si mesmo, mas que possui em sua dinâmica trocas embebidas de aspecto moral. O prestígio do jogador vai ser fundamental para que ele possa estabelecer vínculos entre ele e a casa de apostas e seus companheiros de jogo.
Packagings for the transportation of persimmon and their effects on sensory characteristics
Authors: Martineli Maristella , Rezende Claudia Moraes de , Fonseca Marcos José de Oliveira , Soares Antonio Gomes , Deliza Rosires
Published: April 2019

Abstract: The objective of this work was to evaluate the effect of different packagings for the transportation of the Rama Forte persimmon (Diospyros kaki) cultivar on the sensory characteristics and consumer acceptance of the product during storage. Three types of packagings were evaluated: wooden crate; cardboard boxes; and a new packaging made of recycled polyethylene thermos-injected structure with 10% fodder fiber associated with a polypropylene tray, thermoformed in the exclusive design for persimmon. Check-all-that-apply (Cata) questions were used for the sensory characterization of fruits, revealing differences among samples throughout storage time regarding persimmon sensory attributes and consumer preference. Consumer acceptance of fruits from the wooden and cardboard boxes decreased from the first and fifth day onwards, respectively, as storage time progressed, differing from those from the new packaging, whose appearance was liked up to the ninth day. Persimmon transported in the new packaging showed superior quality throughout shelf life. The new packaging, with an appropriate design, maintains the sensory characteristics of persimmon for a longer time than the other studied packagings.
Fast random wave generation in numerical tanks
Authors: Dimakopoulos Aggelos S. , de Lataillade Tristan , Kees Chris E.
Published: April 2019

Generating and absorbing random waves in numerical models is a challenging problem, in particular when meaningful wave statistics should be generated to meet design sea-state requirements. The methodology presented herein allows for the generation of random wave fields (free surface elevation and velocities) to be reconstructed in time and in space by using window processing from a reference time series. It is demonstrated that the methodology is efficient in reproducing long non-repeating wave sequences by using only O(101)–O(102) wave components, rather than O(103)–O(104) required by a direct reconstruction from a single spectrum. This reduces the computational times required for the development of wave-train time-series elements by 40 times. Errors in instantaneous surface elevation and particle velocity between windowed and non-windowed reconstruction techniques were less than 0·4 and 0·2%, respectively, in the cases considered. The technique was combined with the relaxation zone method typically used in numerical wave tanks for generating waves. The simulations were performed using Proteus, a rapidly developing CFD−FEM toolkit for modelling fluid−structure interaction cases. The use of windowed reconstruction reduced the overall computational time associated with the simulation of waves in a numerical wave tank by ∼40 and ∼70% for serial and parallel execution. Results of the study show windowed reconstruction to be suitable for the representation of long-duration wave trains. Wave height and peak period are conserved within 2 and 1%, respectively.
Modelling the seismic performance of root-reinforced slopes using the finite-element method
Authors: Liang Teng , Knappett Jonathan Adam , Leung Anthony K. , Bengough A. Glyn
Published: April 2019

This paper investigates the seismic performance of rooted granular slopes using dynamic finite-element analysis, validated against recently published centrifuge test data. The importance of selecting suitable strength parameters to represent soil response within a strain-hardening constitutive model was demonstrated and the simulations suggested that any boundary effects introduced through the use of the equivalent shear beam container in the centrifuge are negligible and can be represented by a semi-infinite lateral boundary condition. Using the validated model, a parametric study investigated the effects of different rooted soil properties on the performance of slopes of different heights. Vegetation was effective in reducing deformations at the crest of slopes of modest height, although the benefit reduced as slope height or soil apparent cohesion increased. The effectiveness was significantly affected by the extent of the root system, but only moderately sensitive to root cohesion, and insensitive to stiffness or damping of the rooted soil. Plant species possessing deep and extensive root systems are therefore recommended for seismic stabilisation rather than those with the strongest roots. For modelling purposes, it is sufficient to be able to quantify only the strength of the rooted soil and its area of influence. The magnitude of improvement from vegetation in terms of decreasing seismic permanent slip was also found to be insensitive to the construction method used (i.e. compacted/uncompacted embankment or cutting) for drained granular slopes.
Load effects and associated forces for bridges subjected to light rail transit
Authors: Ji Yongcheng , Kim Yail J.
Published: April 2019

This paper presents a numerical study concerning light rail (LR) bridges, with emphasis on the characterisation of load effects and the interaction between LR loadings and supporting structures. The predicted bridge responses were employed to appraise the provisions of the Association of State Highway and Transportation Officials (Aashto) load and resistance factor design (LRFD) bridge design specifications (BDS) and the American Railway Engineering and Maintenance-of-Way Association manual. Because existing methods to determine live load distributions and skew correction factors are inadequate for LR bridges, new design equations are proposed. A single multiple presence factor of 1·0 is recommended for LR bridges, regardless of loaded tracks. The centrifugal force of curved bridges decays as the radius of curvature increases due to a change in centrifugal acceleration. Regarding the longitudinal force resulting from train braking, multipliers are suggested for design provisions. Temperature-induced loading is distributed to the bridge girders. Rail break is expected up to 75 mm within the range of thermal loading specified in Aashto LRFD BDS, which leads to an increase in dynamic load allowance. The force transfer from superstructure to substructure is marginally influenced by bearing arrangement. A statistical test was conducted to comparatively assess the equivalency of the bridge responses related to the above-mentioned design parameters.
Proyecto comunitario ambiente y territorio: manejo y disposición de residuos sólidos en la vereda pueblo viejo Moniquirá (Boyacá)
Authors: Pita- Morales Luz Adriana , Páez –Saavedra Julián David , Puerta- Gutiérrez Nasly Susana
Published: April 2019

Propósito: el presente artículo tiene como propósito socializar el avance del trabajo comunitario realizado en materia de manejo de residuos sólidos en la vereda pueblo viejo del municipio de Moniquirá- Boyacá. Temas: en este sentido, el creciente deterioro del ambiente causado por la  disposición inadecuada de residuos sólidos trae como consecuencia la degradación de recursos y paisajes en el área rural, por tal motivo surge la necesidad de realizar un acompañamiento e interacción con los habitantes de la vereda con el fin de responder a la necesidad de actuar de manera comunitaria e interinstitucional en la problemática ambiental generada por los desechos. Desarrollo: el  proyecto se desarrolló con un enfoque mixto, donde se aborda el método descriptivo constructivista como hilo conductor del ejercicio. Conclusiones: los resultados reflejan la manera como los habitantes de la vereda pueblo viejo perciben su territorio y el impacto que genera en él los residuos sólidos, así como las entidades que de una u otra manera han contribuido en la región con el tema, posteriormente se realizó un procesos de sensibilización en el cuidado de los recursos naturales de la región el cual se inicia con los habitantes de la vereda a través de los colegios rurales.
Economía social y vivir bien en el contexto urbano: Una experiencia institucional en Medellín, Colombia
Authors: Jiménez – Inchima Indira Isabel , Gómez – Hernández Esperanza
Published: April 2019

Introducción: este artículo presenta los resultados de investigación del estudio realizado en las unidades productivas asociativas que surgen bajo el marco del programa de economía solidaria, desarrollado por el Gobierno Municipal de la ciudad de Medellín, con la intención de mostrar el alcance y las limitaciones que este tipo de propuestas tienen para fortalecer otras formas de organización y producción alternativa basada en la solidaridad, y en esta misma perspectiva, en el mejoramiento de la calidad de vida de las personas que hacen parte de estas. Metodología: se llevó a cabo un estudio de tipo cualitativo, a través de entrevistas directas a profundidad, realizadas a diferentes actores que participan o han participado en el programa de economía solidaria desde el Gobierno Municipal. Resultados: al seguir afianzado bajo una perspectiva de economía de mercado, prevalece la noción de calidad de vida instrumentalizada que invisibiliza otros sentidos de vida que emergen en consonancia con las concepciones propias del vivir bien del contexto analizado. Conclusiones: siguen existiendo aún grandes desafíos, en cuanto a la posibilidad de fortalecer la economía solidaria en Medellín, una economía que esté sustentada en otro tipo de relaciones de producción, intercambio y cooperación, y que fortalezca al sujeto solidario.
Ergen kızlarda polikistik over sendromu: klinik, endokrin ve metabolik bulgular
Authors: ÖZCABI Bahar , TAHMİSCİOĞLU BUCAK Feride , ŞENGENÇ Esma , SUNAMAK Evrim , ADALETLİ İbrahim , KURUĞOĞLU Sebuh , ERCAN Oya , EVLİYAOĞLU Olcay
Published: April 2019

Amaç:
Polikistik over sendromu tanısı alan ergen kızların başvurudaki klinik, metabolik
ve endokrin bulgularını değerlendirmeyi amaçladık.Gereç-Yöntemler: Ocak 2008-Aralık 2012 tarihleri arasında Rotterdam tanı ölçütlerine göre tanılandırılan
53 olgunun yakınmaları, adet düzenleri, fizik bakı bulguları (antropometrik
ölçümler, Ferriman Gallwey skoru, akantozis nigrikans varlığı), bazal/uyarılmış
adrenal androjen, açlık glukoz/insülin değerleri, kan yağ ve lipoprotein
düzeyleri, pelvik ultrasonografi bulguları kaydedildi. Yaşa göre vücut kitle
indeksi (VKİ) %95 ve üzeri olgular şişman olarak tanımlandı. Oligo/amenore,
hiperandrojenizm ve ultrasonografide polikistik over bulgularının hepsinin bulunduğu
hastalar klasik grup olarak adlandırıldı. Kan trigliserit düzeyi yaşa göre %97
değerinden fazla ise yüksek olarak nitelendirildi; HOMA-IR değeri ≥ 3,82 olgularda
insülin direnci var kabul edildi.Bulgular:
Ortalama başvuru yaşı 15±1,5 yıldı. En sık yakınma adet düzensizliğiydi
(%49,1). Adet düzeni ayrıntılı sorgulandığındaysa olguların %60,4’ünde oligo/amenore
olduğu görüldü. Olguların  %43,4’ü
şişmandı. Akantozis nigrikans (%37,7) olan olgularda şişmanlık daha sıktı
(p=0.010). Hirsutizm %41,5 olguda orta-ağır (Ferriman Gallwey skoru≥16) olarak
belirlendi: orta-ağır olgularda oligo/amenore daha sıktı (p=0,007).
İnsülin direnci %39,6 olguda (%81 obez) vardı ve akantozis nigrikans
saptananlarda daha sıktı (p=0,001). Trigliserit
yüksekliği 49 olgudan 7’sinde saptandı; bu olguların hepsinde insülin direnci de
mevcuttu (p=0,033). Serum trigliserit düzeyi ile HOMA-IR değeri arasında
korelasyon saptandı (r:0,415). Polikistik over bulgusu olguların % 96,2’sinde
belirlendi. Klasik grupta diğer gruba göre oligo/amenore, hirsutizm, akantozis
nigrikans, trigliserit yüksekliği anlamlı (p<0.005), total testosteron
düzeyi anlamlılığa yakın yüksekti (p=0.056).

Sonuç: Polikistik
over sendromu tanısında adet düzeni ayrıntılı olarak sorgulanmalıdır. Akantozis
nigrikans saptanan olgular insülin direnci açısından irdelenmeli, insülin
direnci varlığında trigliserit yüksekliği araştırılmalıdır.
Osteoclast (OC) precursor culture v1
Authors: Chen Xiang
Published: April 2019

Osteoclast precursors from human peripheral blood were cultured as previously described. 15 mL of heparin anti-coagulated peripheral blood was obtained by venipuncture from the patient, and a healthy age- and sex-matched control. Peripheral blood mononuclear cells (PBMCs) were isolated using Ficoll-Hypaque Solution. Cells were washed in PBS twice, and plated on 24-well plates at a density of 1×106/well at 37°C in α-MEM, supplemented with 10% FBS, 1% penicillin/streptomycin and 25 ng/ml of macrophage colony stimulating factor (M-CSF) (R&D Systems, Inc., Minneapolis, USA). 6 days later, osteoclast precursor differentiation was induced with the medium supplemented with both 25ng/ml of M-CSF and 30ng/ml RANKL (R&D Systems, Inc., Minneapolis, USA). PBMCs in three wells from each subject were cultured in the absence of M-CSF and RANKL as a negative control.7 days later, TRAP staining was performed using a kit from Sigma-Aldrich (sigma Chemical Co., St. Louis, MO, USA). TRAP-positive cells containing 3 or more nuclei were counted as OCs. 6mm*6mm bovine cortical bone slices were put into cell culture wells at the beginning of OC differentiation. 7 days after co-cultures, the slices were removed and evaluated for OC morphology and pit formation by scanning electron microscope (INCA PENTAFET X3, Oxford Instruments, Abingdon, Oxfordshire, UK).
Intraoperative Doppler ultrasound of the cavernous part of the internal carotid artery in endoscopic transsphenoidal removal of the laterosellar tumors
Authors: Sharipov O. I. , Fomichev D. V. , Kutin M. A. , Kalinin P. L.
Published: April 2019

The study objective is to describe the technique of intraoperative Doppler ultrasound (DU) of brain arteries and to determine the indications for its use during endoscopic transsphenoidal operations. Materials and methods. The study included 100 patients with skull base tumors (pituitary adenomas, trigeminal schwannomas, chordomas), operated via standard or extended transsphenoid endoscopic approaches. For DU, the location of the internal carotid artery (ICA) relative to the surface of the tumor or dura mater was determined as a red and/or blue color of the monitor screen in the M-mode window, accompanied by a characteristic sound signal. Results. DU was used to remove pituitary adenomas in 95 cases, trigeminal schwannomas in 3 cases, chordomas in 2 cases. Intraoperative DU helped to locate the ICA during removal of the laterosellar part of the tumor in all observations. In none of the cases presented were no injuries to the ICA. Сonclusion. DU is an effective and non-invasive method for detecting ICA during endoscopic operations which contributes to the safe disposal of laterosellar tumors. Adequate use of the method does not carry well-known and potential risks. DU should be performed when the tumor is removed from the cavernous sinus or its projection via the lateral extended transsphenoidal endoscopic access (to determine the safe boundaries of the dura mater section in the cavernous sinus projection).
Molecular characterization of extended-spectrum β-lactamase-producing Escherichia coli collected from patients with hematological malignancies during chemotherapy cycles
Authors: Korobova A. G. , Khrulnova S. A. , Tandilova K. S. , Novikova A. A. , Klyasova G. A.
Published: April 2019

Objective:to evaluate the genetic relatedness of extended-spectrumβ-lactamase (ESBL) producing Escherichia coli isolated from the gut in patients with acute myeloid leukemia and lymphoma at admission and during chemotherapy cycles.Materials and methods.The prospective study (2013–2014) included 73 patients (median age 39 years) with acute myeloid leukemia (n = 25) and lymphoma (n = 48). The follow-up period lasted for 96 days. ESBL-producing E. coli isolated from the gut were included in this study. ESBL-production was confirmed by phenotypic tests, blaCTX-Mand blaTEMgenes were detected by polymerase chain reaction, and genotyping was performed by ERIC (Enterobacterial Repetitive Intergenic Consensus) polymerase chain reaction.Results.ESBL-producing E. coli were detected in 39 (53 %) of 73 patients: of them 12 (16 %) patients were colonized at admission and 27 (37 %) patients – during chemotherapy cycles. Gene blaCTX-Mwas detected in 67 % of E. coli, blaTEM– in 41 %, both genes – in 26 %. There was no genetically related ESBL-producing E. coli among 12 isolates detected at admission. Genetic relatedness was detected in 16 (59 %) of 27 isolates obtained during a hospital stay. Genetically related ESBL-producing E. coli were isolated from patients hospitalized in the same and different departments, these isolates were characterized by the presence of both identical and various determinants of resistance.Conclusion.Our data demonstrated the possibility of patient-to-patient transmission of ESBL-producing E. coli isolated from the gut during a hospital stay.
Bone marrow adipocytes and multiple myeloma
Authors: Philchenkov A. A.
Published: April 2019

Multiple myeloma originating from clonal proliferation of plasma cells in the bone marrow is one of the most prevalent hematological malignancies worldwide. The pathogenetic mechanisms of multiple myeloma are far from being elucidated. Nevertheless, it is known that the adipocytes as the prevalent cellular component of bone marrow microenvironment contribute significantly to multiple myeloma growth and progression. The review discloses the recent data on the interactions between bone marrow adipocytes and myeloma cells, hematopoietic stemcells, hematopoietic progenitor cells, mesenchimal stem cells, osteoblasts, osteoclasts, endothelial cells, and cells of immune system. Also, the review places special emphasis on bone marrow adipocyte-produced adipokines, growth factors, cytokines, chemokines, and fatty acids providing the conditions for the preferential growth and migration of malignant plasma cells and contributing to hematopoiesis supression, bone tissue resorption, angiogenesis activation and immunosuppression.
Hellmann Potential in Spinless Salpeter Equation with Potential Barrier within the Framework of Nikiforov-Uvarov method
Authors: Antia Akaninyene Daniel
Published: April 2019

In this paper, we have solved the spinless Salpeter equation (SSE) with Hellmann potential under the framework of NIkiforov-Uvarov (NU) method. The energy eigenvalues and corresponding wave functions for this system express in terms of the Jacobi polynomial are also obtained. With the help of approximation scheme the potential barrier has been evaluated. The results obtained in this work would have many applications in nuclear physics, chemical physics, atomic and molecular physics, molecular chemistry and other related areas as the results under limiting cases could be used to study the binding energy and interaction of some diatomic molecules. As a guide to interested readers, we have provided numerical data which discuss the energy spectra for this system.

 
El origen del conocimiento según Ramón Turró como comienzo psicológico de la epistemología kantiana
Authors: Cano de Pablo Juan
Published: April 2019

Artykuł rozpoczyna się od przedstawienia tekstów Ramóna Turró na temat troficznego pochodzenia wiedzy. Po wprowadzeniu autor niniejszego opracowania wskazuje, że idee Turró są pomyślane jako uzupełniająca teoria epistemologii Kanta, ujawniona głównie w Krytyce czystego rozumu. Rozumiane w ten sposób teorie Turró mogą wyjaśniać, w jaki sposób wiedza zaczyna się w doświadczeniu, podczas gdy w epistemologii Kanta odnoszą się do racjonalnych mechanizmów, które dają uniwersalność i konieczność wiedzy naukowej. Kant realizuje bowiem teorię epistemologiczną, natomiast Turró przeprowadza psychologiczną teorię genezy wiedzy. Z tej perspektywy, oraz w oparciu o teksty Miguela de Unamuno, autor artykułu pokrótce analizuje pojęcia tak fundamentalne, jak: rzeczywistość, istnienie, przestrzeń, wiedza, instynkt czy zachowanie. W końcowej części znajduje się krótka refleksja nad Arystotelesowskimi koncepcjami zwierzęcej phronesis i żywienia, w których Stagiryta może być uznany za prekursora idei Turró.
Referendum ogólnokrajowe w republikach bałtyckich po 1991 roku – analiza porównawcza
Authors: Maj Dorota
Published: April 2019

Demokracja bezpośrednia jest postrzegana jako komplementarna forma sprawowania władzy względem demokracji przedstawicielskiej. Z założenia ma rekompensować niedostatki demokracji pośredniej, a także gwarantować bezpośredni udział obywateli w sprawowaniu władzy. Jedną z instytucji demokracji bezpośredniej, gwarantowaną w konstytucjach i innych aktach prawnych Litwy, Łotwy i Estonii, jest referendum ogólnokrajowe. Pomimo podobnych doświadczeń historycznych i zbieżnych rozwiązań przyjętych w systemach politycznych referendum ogólnokrajowe spełnia inne funkcje. Jest to pochodną problemów społecznych i politycznych tych państw, jak również kształtu sceny politycznej.
Ruch pokojowy w RFN (Friedensbewegung) w pierwszej połowie lat osiemdziesiątych XX wieku
Authors: Świder Małgorzata
Published: April 2019

W latach 80. XX wieku ruch pokojowy mobilizujący setki tysięcy osób w protestach przeciwko podwójnej uchwale NATO z grudnia 1979 r. był istotnym elementem zachodnioniemieckiej sceny politycznej. Wpływał na układ sił i konflikty wewnętrzne w socjaldemokracji niemieckiej (SPD); będąc największym oponentem polityki prowadzonej przez rząd kanclerza Helmuta Schmidta, przyczynił się do powstania Partii Zielonych, a jego działania doprowadziły do zaistnienia polemiki w związkach zawodowych i były bodźcem do dyskusji etycznych i religijnych w Kościele katolickim i protestanckim w RFN. Stał się również przedmiotem wielu kontrowersji oraz symbolem aktywności i siły społecznej.
PEGIDA – polityczny ruch protestu
Authors: Macała Jarosław Edward
Published: April 2019

Ruchy protestu związane ze skrajną prawicą działają w Niemczech na przestrzeni wielu lat. Jednak żaden nie zyskał takiego rozgłosu i poparcia jak antyislamska PEGIDA. Ten ruch protestu przez swoje niekonwencjonalne, lecz z reguły pokojowe i legalne protesty dotyczące polityki migracyjnej zintegrował i zmobilizował wiele tysięcy niezadowolonych Niemców. Zmusił też do reakcji elity polityczne oraz zmobilizował przeciwników PEGIDY wśród społeczeństwa niemieckiego. Pokazał dużą frustrację i niezadowolenie części obywateli. Wydaje się, iż celowo przesadzona groźba islamizacji Niemiec i Europy to pretekst dla zwolenników PEGIDY, żeby w sposób typowy dla wielu politycznych ruchów protestu pokazać swoją antyestablishmentowość, niezadowolenie z tradycyjnego sposobu uprawiania niemieckiej polityki, z alienacji elit politycznych, z arogancji władzy. W programie i działalności PEGIDY silne jest populistyczne rozróżnienie między „nami”, czyli normalnymi ludźmi, a „nimi”, czyli oderwanymi od rzeczywistości przedstawicielami elit. Celem jest zmiana modelu niemieckiej demokracji w kierunku demokracji bezpośredniej, żeby głos obywateli liczył się bardziej niż elit.
The role of occupational health services in the universal health coverage era in Indonesia
Authors: Mansyur Muchtaruddin
Published: April 2019

In accordance to Act No 24 Year 2011 on The Social Security Administrating Body, the Indonesian National Social Security program is managed by  two national organizations, namely: Social Security Administering Body for Health (Badan Penyelenggara Jaminan Sosial Kesehatan = BPJS Kesehatan) and Social Security Administering Body for Labor (Badan Penyelenggara Jaminan Sosial Ketenagakerjaan = BPJS Ketenagakerjaan). The former is responsible for providing health coverage for all Indonesians through the National Social Health Insurance Scheme known as the Jaminan Kesehatan Nasional/JKN. The latter is  responsible for  providing the worker's social security consisting of Provident Fund Benefit, Accident Benefit, Pension Benefit, and Death Benefit.1The Indonesian government has been continuously improving the health service program towards better national universal health coverage and has set the 2019 functional achievement target of 95% of the population enrolled in the program. To ensure that this target of  the program will be achieved,  the government pays the premium of BPJS Kesehatan of the poor and near poor.2
Mild anxiety and depression related to elevated dopamine level
Authors: Fidianingsih Ika , Nurmasitoh Titis , Arjana Adika Zhulhi , Devita Ninda , Khoiriyah Umatul
Published: April 2019

BackgroundDopamine is an important neurotransmitter that plays a role in the pathogenesis of anxiety and depression. Dopamine secretion occurs when there is a pleasurable stimulus. Blood dopamine levels have the potential to be developed as biomarkers of depression or anxiety, but previous studies related to the relationship between dopamine levels and levels of anxiety and depression are still controversial. The purpose of this study was to determine the correlation between anxiety and depression score with dopamine level in young adults. MethodsThis was an observational cross sectional study. A total of 43 subjects aged 18 to 40 years were recruited by consecutive non-random sampling according to inclusion and exclusion criteria. Anxiety and depression were assessed using the Beck anxiety inventory and Beck depression inventory-II questionnaire. Dopamine plasma level was measured using the enzyme-linked immunosorbent assay (ELISA). The Spearman rho correlation test was used to analyze the data and p<0.05 was considered significant.Results The median dopamine levels in respondents with mild, moderate and severe anxiety were respectively: 77.79; 63.43; 62.51 ng/mL (p=0.043). The median dopamine levels in respondents with reasonable depression, mood disorder, moderate and severe depression were respectively: 79.2; 61,32; 62,51; 60.24 (p=0.001). Correlation test results showed a weak correlation between dopamine and anxiety (r=- 0.310) and a moderate correlation for depression (r=-0.505).ConclusionMild anxiety and depression were associated with elevated dopamine level in young adults. Further studies are required to confirm the role of dopamine metabolism in anxiety and depression in young adults.
Régimen jurídico del distintivo de calidad en la producción agraria
Authors: Sánchez Hernández Angel
Published: April 2019

El consumidor demanda productos agrarios de calidad y al mismo tiempo que saludables, satisfagan el paladar. Esa exigencia de calidad de los consumidores por los productos alimentarios depende de la garantía de obtenerlos sometidos controles rigurosos. La promoción de la calidad en la producción agraria fue recogida por la Unión Europea, en disposiciones referidas a productos agrarios distintos del vino: los Reglamentos comunitarios nº 2081/92 relativo a la protección de las indicaciones geográficas y de las denominaciones de origen de los productos agrícolas y alimenticios y nº. 2082/92 de certificaciones de especificidad de los productos agrarios y alimentarios.
Editorial
Authors: Martínez de Pisón José
Published: April 2019

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Los derechos fundamentales y la Constitución a los veinticinco años
Authors: Martín-Retortillo Baquer Lorenzo
Published: April 2019

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La presupuestación por programas en la Comunidad Autónoma de La Rioja
Authors: Piña Garrido María Dolores
Published: April 2019

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El tratamiento invisible de datos de carácter personal en Internet
Authors: Yanguas Gómez Roberto
Published: April 2019

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Notas para el estudio de la naturaleza jurídica de la Jurisdicción voluntaria (a propósito del Anteproyecto de Ley de Jurisdicción Voluntaria de Octubre de 2005)
Authors: Liébana Ortiz Juan Ramón
Published: April 2019

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Los planes de gestión y los programas de medidas en la Directiva Marco de Aguas. Su confusa transposición al Derecho español.
Authors: Fanlo Loras Antonio
Published: April 2019

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La neutralidad del Estado en el ámbito escolar Suizo. Una especial consideración del cantón de Ginebra.
Authors: Eisenring Gabriela
Published: April 2019

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El derecho de los padres a elegir el tipo de educación que deseen para sus hijos
Authors: Marcos Pascual Enrique
Published: April 2019

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