bluuebunny/crossref_metadata_2025 huggingface dataset:
SEMNet: A Simple and Efficient MLP-based Network for 3D Face Point Clouds Landmarks Localization
Authors: Lei Mingyang , Song Hong , Fu Tianyu , Xiao Deqiang , Ai Danni , Fan Jingfan , Yang Yifei , Gu Ying , Yang Jian
Published: May 2024

Accurately localizing landmarks on 3D faces is critical for various applications, such as expression recognition, facial surgery navigation, and lip shape analysis. Existing landmarks localization methods generally contain complex calculation processes, which may affecting the efficiency. To address this problem, we propose a Simple and Efficient MLP-based Network (SEMNet) for landmarks localization. We first design a lightweight enhanced geometric affine module to adaptively transform point features in local region, for improving performance and generalization. Then, to fully utilize the rotation information of the face, a rotation constraint auxiliary branch is introduced for assisting in locating landmarks. In addition, to generate more accurate results, we propose a residual graph convolution discriminator to distinguish predicted locations from real face point clouds locations. Experimental results on two public datasets (FRGC v2 and Bosphorus) show that our method achieves high accuracy and efficiency compared to state-of-the-art methods. The project page is available at https://github.com/leimingyangde/SEMNet.
Comparative biochemical and pharmacodynamic analyses of Asarum heterotropoides Fr. Schmidt var. mandshuricum (Maxim) Kitag and Asarum sieboldii Miq var. seoulense Nakai roots
Authors: Wang Zhiqing , Li Huiling , Zhao Guangyuan , Wang Yanhong , Xu Xuanwei , Wang Yingping , Zhang Ze , Wang Guanghui
Published: May 2024

Background
Asarum heterotropoides and Asarum sieboldii are commonly used in traditional Chinese medicine. However, less is known about how they differ in terms of essential oil (EO) and ethanol extract (EE) content and composition. Moreover, the impact of various geographical locations on the essential oil (EO), ethanol extract (EE), and asarinin content of different Asarum samples remains unknown. We tested four root drying methods, i.e. soil removal and shade drying (P1), water washing and shade drying (P2), water washing and drying at 30 ℃ (P3) and 40 ℃ (P4). We used LC-MS and GC-MS to investigate these differences. We also investigated the pharmacodynamic effects of EO and EE.
Result
Overall, the EO, EE and asarinin contents of the analysed samples were 19.21–51.53 µL.g-1, 20.00–45.00 µL.g-1 and 1.268–2.591 mg.g-1, respectively. P1 treatment yielded the lowest volatile oil content as compared to the other three treatments. GC-MS analysis revealed 78 EO components. Among the six major EO components, eucarvone, 3,5-dimethoxytoluene and methyl eugenol were higher in A. heterotropoides than in A. sieboldii. However, the latter had a higher myristicin content. LC-MS analysis identified 888 EE components in roots and leaves of A. heterotropoides and A. sieboldii; 317 differentially accumulated metabolites were identified. EO and EE showed a dose-dependent reduction in the degree of swelling and an increase in the inhibition rate of drug concentration on acetic acid writhing in mice. Asarum EO proved to be more effective than EE in the pharmacodynamic study.
Conclusion
We conclude that Asarum species show inter- and intra-specific differences in EO, EE content and composition, which may influence the pharmacodynamics of Asarum root extracts.
Betonarme Çerçevelerde Yumuşak Kat Etkilerinin Yeni Nesil Dolgu Duvarlar ile Azaltılması
Authors: Balenda Bakala Prost Iverden , Mısır İbrahim Serkan , Aldemir Ömer
Published: May 2024

Çeşitli amaçlarla özellikle zemin kat dolgu duvarları kaldırılmış çok sayıda binanın depremler sırasında bu katta artan yanal deplasman talebiyle yumuşak kat/zayıf kat mekanizmaları sergilediği ve binanın bu kat üzerine çöktüğü geçmiş depremlerden bilinmektedir. Sunulan çalışmanın amacı, 2018 Türkiye Bina Deprem Yönetmeliği’nde de kabul gören yeni nesil dolgu duvarların betonarme çerçevelerde yumuşak kat oluşumunu azaltmadaki etkilerini araştırmaktır. Çalışma kapsamında dolgulu betonarme çerçeve modelleri üzerinde doğrusal olmayan analizler gerçekleştirilmiş, göz önüne alınan çok katlı düzlemsel çerçevelerde yumuşak kat etkilerinin belirgin hale gelmesi için modellerde yalnızca üst katların açıklıklarında dolgu duvar etkisi dikkate alınmıştır. Analizde kullanılan çerçeve ve dolgu duvar parametreleri, dolgu duvarlı ve dolgu duvarsız düzlemsel betonarme çerçeveler üzerinde daha önce yürütülen yarı statik testlerden elde edilmiştir. Simülasyonlar, geleneksel dolgu duvar durumuna kıyasla yeni nesil duvar kullanımının, ilk katları dolgusuz binalarda bile yumuşak/zayıf kat oluşumunu azaltma potansiyeline sahip olduğunu göstermektedir.
Gravity Tensors and Moho Depth Variations of the Region between West Italy and Eastern of Caspian Sea
Authors: Doğru Fikret , Pamukçu Oya
Published: May 2024

The crust structure of the region from the west of Italy to the east of the Caspian Sea was examined within the scope of this study. In addition, the effect of both the shallow and deep structure were revealed by calculating the gravity tensors of the region in different degrees. For this purpose, the spherical free air gravity anomaly of the region was first calculated. The combination of EGM2008 and GOCE DIR R4 models were used for this calculation. Then the gravity tensors of the region were calculated separately using only EGM2008 model and only GOCE DIR R4. The spherical free air anomaly of the region was calculated using the topographic model. The spherical Bouguer anomaly of the region was obtained by subtracting the anomaly obtained from this topographic model from the spherical free air anomaly obtained from GOCE DIR R4 + EGM2008 combined model. The radial averaged power spectrum of the spherical Bouguer anomaly was taken and the anomaly thought to be caused by Moho was filtered out. Moho depth map of the whole region was obtained by applying the Parker-Oldenburg inversion to the filtered anomaly. The obtained values were compared with previous studies and found to be compatible.
TACO: An Ontology in Turkish for Identifying and Controlling Plant Pests, Weeds and Diseases
Authors: Öztürk Övünç
Published: May 2024

While ensuring a more sustainable production, because of reduced chemical usage it is more complicated to control plant pests, diseases and weeds in smart agriculture. For this reason, it is of great importance to detect pests, diseases and weeds at the earliest stage. It is important that both farmers and the artificial intelligence applications developed for agricultural control should be able to detect these organisms and to know the agricultural control methods. Semantic technologies and ontologies provide machine interpretable information and solutions for heterogeneity. This study presents the Turkish Agricultural Control Ontology (TACO), which is built in Turkish and contains information about plant pests, diseases and weeds common in Turkey. The contributions of the study are that it is the first Turkish ontology built in this field and that the methods of agricultural control are included within the scope of the ontology. According to the commonly used ontology evaluation metrics, TACO is predominantly characterized as a deep classification taxonomy. In addition, it was concluded that the classes in the ontology have an evenly distributed and sufficient number of class individuals.
In Situ Characterization of the Locked Particle Behavior of Sulfide Minerals Using Non-Destructive Electrochemical Measurements
Authors: İzerdem Damla , Ertekin Zeliha
Published: May 2024

The flotation of sulfide minerals mostly depends on electrochemical reactions occurring on the mineral surfaces. Understanding the interaction mechanisms in the pulp is crucial for explaining the effects of different flotation chemicals on flotation performance. For this purpose, electrochemical techniques are used in the flotation of sulfide minerals by utilizing the semiconductor properties of these minerals. In this study, three non-destructive electrochemical measurements - open circuit potential (OCP), cyclic voltammetry (CV), and electrochemical impedance spectroscopy (EIS) - were used to assess the electrochemical reactivity of the locked and liberated sulfide particles. Various combinations of mineral electrodes - Galena/Pyrite (0.52 cm2), Galena/Sphalerite (0.35 cm2), pure Galena (0.20 cm2), pure Sphalerite (0.80 cm2) and pure Pyrite (0.18 cm2) - were tested. A three-electrode electrochemical cell configuration was set up to investigate the electrochemical responses of the prepared electrodes. The changes in the surface chemistry of the mineral electrodes, in the presence (1×10-4 M NaEX) and absence of a collector were compared in detail. During the process, charge transitions occurred between the minerals in the locked particle mineral electrode due to galvanic interactions regardless of the surface area. Thus, the flotation behavior of the minerals changed by reducing and oxidizing each other. The present study suggests that the electrochemical methods may be an alternative technique to the conventional batch scale flotation tests as they can easily monitor the effect of any flotation reagents in the system causing possible reactions that may occur on sulfide mineral surfaces.
Hidrojen Üretimi ve CO2 Yakalanmasını Aynı Cihazda Sağlayan Bir Membran Reaktörün Matematiksel Modelinin Geliştirilmesi
Authors: Nalbant Atak Yağmur
Published: May 2024

Sürdürülebilir bir gelecek için temel bir unsur olan hidrojen, küresel enerji ve çevresel zorluklarda önemli bir rol oynamaktadır. Hidrojen üretimi için öne çıkan yöntemlerden biri, yüksek verimlilik ve ölçeklenebilirlik sunan hidrokarbonlardan buhar metan reformasyonudur (BMR). Membran reaktörler (MR’ler), hidrojen üretimini ve ayrılmasını tek bir ünite içinde entegre ederek BMR sürecini geliştirmek için umut verici bir teknoloji olarak ortaya çıkmıştır. Bu çalışma, bir MR içerisinde hem BMR ile hidrojen üretimini hem de membrandan geçemeyen gazlardan karbondioksit yakalanmasını içeren iki farklı prosesi içermektir ve bu MR’nin 1-boyutlu matematiksel modeli oluşturulmuştur. İki önemli çalışma parametresinin (reaksiyon sıcaklığı ve reaksiyon basıncı) membran reaktör performansı üzerindeki etkileri parametrik olarak incelenmiştir. Temel simülasyon koşullarında (773 K ve 3 bar), metan dönüşümü, hidrojen geri kazanımı, karbondioksit geri kazanımı sırasıyla %32,43, %61,78 ve %15,69'a eşittir.
Aspects regarding the cutting of the material in the case of certain processing by plastic deformation of thin blank-tape
Authors: CHIOIBAS A
Published: May 2024

By this cutting, we consider a maximum efficient use of the surface of the thin blanktape, which is achieved by a judicious establishment of the relative positions of the pieces on its surface, so that the quantity of resulting waste is minimal. This will reflect on the productivity, the cost of finished pieces and stamping die, as well as the level of exploitation of the presses, knowing that complex presses confer the highest quality. Furthermore, the cutting of strips for the case in which parts are processed by deep drawing is important for a proper sheet metal deformation, thus achieving high-quality results.
Identifying and understanding the concept of hate crime in criminal law the jurisprudence of the European Court of Human Rights
Authors:   Police Academy “Alexandru Ioan Cuza”, Calancia R. C.
Published: May 2024

The continuous development of society has led to the birth of conflicts between the human beings who share it. Therefore, the many human characters and the continuous existence of differences of any kind between the individuals of a society led to the birth of the concept of hate crime. The internal motive of this criminal activity is given by the motive of the deed, which is the one on which the feeling of hatred takes shape in the mind of the author of the deed. Close by, we will draw defining lines of the perpetrator's way of thinking before the implementation of the illegal activity, as well as the steps that the competent bodies take in the criminal investigation.
Optimization of sensor data gathering interface for Platmarisc project
Authors: Atodiresei A.
Published: May 2024

Software interfaces enable communication between different system components, regardless of platform, language, or hardware. They integrate existing components and make development easier. Protocols and technologies like XML, JSON, and WebSockets facilitate this communication. As technology evolves, interfaces will become more complex and specialized for real-time communication, particularly in IoT. Effective interfaces are essential for modern software development. In this article, we analyzed various communication protocols considered for the implementation of the Platmarisc project (including REST, XMLRPC, RPC, SOAP, JSON-RPC, GraphQL, HTTP POST, WebSockets, and MQTT).
El Hollywood de Quentin Tarantino. Análisis de la intertextualidad falsa en Pulp Fiction, Bastardos sin gloria y Había una vez en…Hollywood
Authors: Dumont González Gabriel
Published: May 2024

A lo largo de la historia, la literatura ha brindado significativas posibilidades prácticas y teóricas al cine. En relación con la última, la teoría de la transtextualidad, elaborada por Gérard Genette, ha cobrado gran relevancia para el estudio de películas y series, debido a la extensa cantidad de citas y alusiones de unas obras dentro de otras. Esto propició que los teóricos cinematográficos Robert Stam, Robert Burgoyne y Sandy Flitterman-Lewis elaboraran cinco relaciones transtextuales adicionales pensadas expresamente para el cine. En la actualidad, el cineasta Quentin Tarantino es quien más emplea la mayoría de las formas transtextuales en su filmografía, como parte de su estilo autoral; incluso, ha creado películas y series falsas que solo existen dentro de su filmografía, que se pueden analizar como otra forma de transtextualidad. Por tanto, emplearemos la noción de intertextualidad falsa, de Stam, Burgoyne y Flitterman-Lewis para estudiar estos casos de películas y series falsas creadas por Tarantino, así como los diversos propósitos narrativos y estilísticos que tienen dentro de su filmografía.
Teacher and Student Experiences in a Gender-Inclusive Secondary Computer Science Program
Authors: Michael Karlin  , Ottenbreit-Leftwich Anne , Liao Yin-Chan Janet
Published: May 2024

A significant gender gap continues to exist within computer science (CS) education, despite a nationwide emphasis in the U.S. on increasing CS education equity and access.  To explore this issue, we conducted an ethnographic case study within a classroom at Forest View High School (FVHS, pseudonym) where girls’ participation in CS was consistently higher than state averages over 12 years. We sought to understand teacher and student experiences within this gender-inclusive program. Data were collected over three months through observations, interviews, course documents, and reflections. Results indicate three strategies for supporting a more gender-inclusive classroom: (1) Providing personalized and relevant learning experiences; (2) modeling a growth mindset; and (3) creating a welcoming environment. Implications for practice include providing assignment choice, providing opportunities to learn from failure, and building personal relationships with students. Overall, teachers can act as agents of social change within the CS classroom, and play an essential, central role in broadening participation and equity initiatives. However, this work must also be supported by administrators, counselors, and other school stakeholders to be effective for enacting change.
The Effects of Programming Teaching on Pre-Service Teachers' Self-Efficacy Beliefs and Computational Thinking Skills
Authors: ERÜMİT Ali Kürşat , ÖZMEN Sefa , CEBECİ Hasan Yiğit
Published: May 2024

In this study, it was aimed to determine the effects of programming teaching with different programming tools on pre-service elementary mathematics teachers' self-efficacy beliefs towards mathematics teaching and computational thinking skills. The study was conducted in accordance with the mixed research method with 47 university students studying in the Elementary Mathematics Teacher Education Program and taking the "Algorithm and Programming" course for 12 weeks. The findings of the study show that there is a significant relationship between the computational thinking skills of prospective elementary mathematics teachers and their self-efficacy beliefs towards mathematics teaching. In addition, it was determined that there was a significant improvement in pre-service elementary mathematics teachers' computational thinking skills and their self-efficacy beliefs towards mathematics teaching with programming teaching in which different programming tools were used. In the last part of the article, various suggestions are presented for researchers who want to work in this field.
Occurrence and potential environmental risk assessment of alkylphenols and bisphenols in surface water collected in rivers flowing through Bac Ninh, Vietnam
Authors: Thi Thu Nguyen , Thi Quynh Mai Duong , Cam Tu Vu , Thi Thao Nguyen , Dinh Binh Chu , Hoang Anh Nguyen , Van Hoi Bui
Published: May 2024

In recent decades, increasing attention has been directed toward the effects of alkylphenols and bisphenols due to their demonstrated endocrine-disruptive effects. This study investigated the occurrence and potential risk assessment of two alkylphenols and seven bisphenols in surface water collected from rivers (Cau River, Duong River, and Thai Binh River) flowing through Bac Ninh province, one of the pivotal economic regions in the North of Vietnam. The results demonstrated that these compounds were widely distributed in the rivers. The average concentrations were ranked as follows: 4-tert-octylphenol (4-t-OP) (91.2 ng/L) > 4-nonylphenol (4-NP) (78.9 ng/L) > bisphenol S (BPS) (72.4 ng/L) > bisphenol A (BPA) (5.6 ng/L) > bisphenol F (BPF) (below method detection limit) with detection frequencies of 100% (except for BPF of 23%). The presence of alkylphenols and bisphenols in aquatic environments closely correlates with anthropogenic activity. The environmental risk assessment was carried out based on the Risk Quotient (RQ) evaluation, indicating that 4-NP poses medium risk in all three rivers. In addition, 4-t-OP, which is more toxic than 4-NP, poses high risk to aquatic organisms in the Duong River (RQ = 1.1), while BPA and BPS show low risk to aquatic organisms in three rivers (RQ < 0).
A soft-sensor approach for predicting an indicator virus removal efficiency of a pilot-scale anaerobic membrane bioreactor (AnMBR)
Authors: Kadoya Syun-suke , Zhu Yifan , Chen Rong , Rong Chao , Li Yuyou , Sano Daisuke
Published: May 2024

The anaerobic membrane bioreactor (AnMBR) is a promising technology for not only water reclamation but also virus removal; however, the virus removal efficiency of AnMBR has not been fully investigated. Additionally, the removal efficiency estimation requires datasets of virus concentration in influent and effluent, but its monitoring is not easy to perform for practical operation because the virus quantification process is generally time-consuming and requires specialized equipment and trained personnel. Therefore, in this study, we aimed to identify the key, monitorable variables in AnMBR and establish the data-driven models using the selected variables to predict virus removal efficiency. We monitored operational and environmental conditions of AnMBR in Sendai, Japan and measured virus concentration once a week for six months. Spearman's rank correlation analysis revealed that the pH values of influent and mixed liquor suspended solids (MLSS) were strongly correlated with the log reduction value of pepper mild mottle virus, indicating that electrostatic interactions played a dominant role in AnMBR virus removal. Among the candidate models, the random forest model using selected variables including influent and MLSS pH outperformed the others. This study has demonstrated the potential of AnMBR as a viable option for municipal wastewater reclamation with high microbial safety.
Emicizumab as a Promising Form of Therapy for Type A Hemophilia - A
Review of Current Knowledge from Clinical Trials
Authors: Grabowska Katarzyna , Grzelak Michalina , Zhao Lin-Yong , Płuciennik Elżbieta , Pasieka Zbigniew , Kciuk Mateusz , Gielecińska Adrianna , Smakosz Aleksander K. , Kałuzińska-Kołat Żaneta , Kołat Damian
Published: May 2024

:

Hemophilia is a plasma bleeding disorder characterized by a deficiency of certain blood
clotting factors. The most common forms of this disease, i.e., type A and type B, affect approximately
400,000 people worldwide. Without appropriate treatment ensuring the proper coagulation
cascade, this disease may lead to serious disability. Minimizing patient discomfort is possible via
replacement therapy, consisting of the substitution of a missing coagulation factor via intravenous
administration. Frequent medication and the risk related to factor inhibitors are significant disadvantages,
necessitating the improvement of current therapies or the development of novel ones.
This review examines the humanized bispecific antibody Emicizumab which ensures hemostasis
by mimicking the action of the coagulation factor VIII, a deficiency of which causes type A hemophilia.
The paper outlines the topic and then summarizes available clinical trials on Emicizumab
in type A hemophilia. Several interventional clinical trials have found Emicizumab to be
effective in decreasing bleeding episodes and raising patient satisfaction among various hemophilia
A populations. Current Emicizumab-related trials are forecast to be completed between
2024 and 2030, and in addition to congenital hemophilia A, the trials cover acquired hemophilia A
and patients playing sports. Providing a more comprehensive understanding of Emicizumab may
revolutionize the management of hemophilia type A and improve quality of life. Conclusively,
Emicizumab is a gentler therapy owing to subcutaneous delivery and fewer injections, which reduces
injection-site reactions and makes therapy less burdensome, ultimately decreasing hospital
visits and indirect costs.
Can Gender-Specific Renal and Visceral Fat Evaluated by CT Predict the
Fuhrman Nuclear Classification of Clear Cell Renal Cell Carcinoma?
Authors: Li Xiaoxia , Lin Jinglai , Guo Yi , Lin Dengqiang , Zhou Jianjun
Published: May 2024

Background:

Evidence of the association between obesity and renal cell carcinoma progression is contradictory. The effects of renal cell carcinoma on fat
distribution are still unknown.

Objective:

The goal of this study was to determine the ability of various forms of fat deposition to predict the Fuhrman nuclear grade of clear cell renal cell
carcinoma [ccRCC].

Methods:

This retrospective study included 320 patients with pathologically proven ccRCC [215 men and 105 women; 263 low-grade ccRCC and 57 highgrade
ccRCC]. Based on computed tomography scans, adipose tissue in various body regions was classified into the perirenal fat area [PFA],
visceral fat area [VFA], total fat area [TFA], subcutaneous fat area [SFA], and hepatic steatosis [HS]. Subsequently, the relative VFA [rVFA] was
computed. Age, sex, body mass index, and maximal tumor diameter were also regarded as clinical factors. Univariate and multivariate logistic
regression studies were conducted to evaluate whether there was an association between body fat composition and the Fuhrman classification and
whether it was related to gender.

Results:

After correcting for age, males with low-grade ccRCC exhibited higher TFA [257.6 vs. 203.0, p = 0.002], VFA [151.6 vs.115.5, p = 0.007], SFA
[106.0 vs. 87.5, p = 0.015], PFA [55.1 vs. 30.4, p < 0.001], and HS [18% vs. 0%, p = 0.031] than those with high-grade ccRCC. There was no
significant difference among rVFA in males. In females, there was no significant difference in any of the parameters. VFA and PFA remained
independent predictors for high-grade ccRCC in males in both the monovariate [VFA: odds ratio [OR] 0.992, 95% confidence interval [CI]
0.987–0.997, p = 0.004; PFA: OR 0.949, 95% CI 0.930–0.970, p < 0.001] and multivariate [VFA: OR 1.028, 95% CI 1.001–1.074, p < 0.001;
PFA: OR 0.878, 95% CI 0.833–0.926, p < 0.001] models.

Conclusion:

Gender-specific adipose tissue in different locations demonstrated varied values for predicting high-grade ccRCC and may be utilized as an
independent predictor of high-grade ccRCC in male patients.

conclusion:

Gender-specific adipose tissue in different locations demonstrated varied values for predicting high-grade ccRCC and may be utilized as an independent predictor of high-grade ccRCC in male patients.

other:

Sex-specific adipose tissue in various places exhibits variable values for high-grade ccRCC prediction.
Exploration of Potential Targets and Molecular Mechanisms of the Yiqi
Jianpi Tongqiao Formula in Treating Allergic Rhinitis Mouse Model based
on Network Pharmacology and Molecular Docking
Authors: Huang Sihong , Huang Yue
Published: May 2024

Objective:

To investigate the therapeutic effect of Yiqi Jianpi Tongqiao (YJT) formula (Hedysarum Multijugum Maxim, Magnoliae Flos, Xanthii Fructus, Notopterygii Rhizoma
Et Radix, Kaempferiae Rhizoma, Acoritataninowii Rhizoma, Saposhnikoviae Radix) on an
allergic rhinitis mouse model, and to explore the active ingredients, key targets, and
molecular mechanisms of this formula using network pharmacology and molecular docking
methods

Methods:

An allergic rhinitis mouse model was established to observe changes in rhinitis symptoms, nasal mucosal morphology, and serum indicators after administering the YJT formula.
The TCMSP, GeneCards, OMIM, and DisGeNET databases were used to screen for the active
ingredients, action targets, and disease targets of the YJT formula. The Cytoscape software was
used to construct a network of the active ingredients and action targets. The protein-protein interaction (PPI) network was used to predict hub genes. The corresponding active compounds
with the hub genes' highest oral bioavailability (OB) values were identified, followed by molecular docking analysis.

Results:

Animal experiments demonstrated that the YJT formula reduced rhinitis symptoms
(nasal itching, runny nose, and face scratching) in allergic rhinitis mice, as well as decreased
nasal mucosal inflammatory reactions and serum inflammatory indicators (histamine, OVAspecific IgE, IL-1β levels). Furthermore, 63 active components and 101 potential indicator targets of the YJT formula were identified, along with 5 hub genes (IL6, AKT1, IL1B, VEGFA,
and PTGS2), and the corresponding active compounds with the highest OB values were quercetin, aloe-emodin, and denudanolide b. Molecular docking results revealed the binding energy
between quercetin, aloe-emodin, denudanolide b and 5 hub genes (IL6, AKT1, IL1B, VEGFA,
and PTGS2) were -5.78 to -10.22 kcal/mol, the binding energy between dexamethasone and 5
hub genes were -6.3 to -9.7 kcal/mol. In addition, GO and KEGG analysis suggested significant
enrichment of these genes in biological processes such as response to lipopolysaccharide, response to molecule of bacterial origin, and response to reactive oxygen species, as well as signaling pathways like AGE-RAGE signaling pathway in diabetic complications, Lipid and atherosclerosis, and IL-17 signaling pathway.

Conclusion:

The YJT formula has therapeutic effects in an allergic rhinitis mouse model,
with the main active components being quercetin, aloe-emodin, and denudanolide b, and the
key targets being IL6, AKT1, IL1B, VEGFA, and PTGS2, involving multiple signaling
pathways.
A Short Appraisal on Nano-biosensors for Epigenetic Changes Detection: A Transformative Innovation
Authors: Singh Dilpreet
Published: May 2024

This mini-review article focuses on the recent advancements in nano-biosensors for
the detection of epigenetic changes, a burgeoning field at the intersection of nanotechnology and
cancer diagnostics. Epigenetic modifications, including DNA methylation, histone modification,
and non-coding RNA expression, play a crucial role in cancer progression and drug resistance.
The advent of nano-biosensors has introduced highly sensitive and specific methods for detecting
these changes, surpassing the capabilities of traditional diagnostic tools. This article delves
into various nano-biosensors, such as gold nanoparticles, quantum dots, carbon nanotubes, and
graphene oxide sensors, highlighting their unique properties and applications in detecting epigenetic
markers. It emphasizes the significance of early and accurate detection of epigenetic alterations
in cancer, which opens new pathways for early diagnosis, monitoring treatment efficacy,
and developing personalized therapeutic strategies. The review also addresses the technical challenges
and limitations of current nano-biosensor technologies, including issues related to sensitivity,
specificity, and biocompatibility. Furthermore, it explores the ethical and safety considerations
in the clinical application of these nanotechnologies. The discussion extends to the potential
future developments in this field, emphasizing interdisciplinary research and the integration
of artificial intelligence for data analysis. This comprehensive overview of nano-biosensors for
epigenetic change detection underscores their transformative potential in cancer research, offering
insights into their current state, challenges, and future prospects in advancing personalized
cancer care.
Drug-induced Tongue Disorders: A Comprehensive Literature Review
Authors: Amiri Shiva , Nikvarz Naemeh , Sabouri Salehe
Published: May 2024

Background::

Some drugs cause tongue disorders as adverse effects. Most of the druginduced
tongue disorders are benign and will resolve after drug discontinuation. However, the
changes in the color or appearance of the tongue may frighten patients and decrease compliance
with drug therapy.

Objective::

To review the literature to find all reports of drug-induced tongue disorders, their
presentation, management, and outcome of patients

Methods::

The search was conducted in Google Scholar and PubMed using key words “ageusia,”
“burning tongue,” “coated tongue,” “drug-induced taste disturbances,” “dysgeusia,” “glossitis,”
“glossodynia," “hairy tongue,” “hypogeusia,” “stomatodynia,” “stomatopyrosis,” “swollen
tongue” “tongue discoloration,” “tongue irritation,” “tongue numbness, “tongue oedema,” and
“tongue ulcer. All reports that were published from 1980 to 2022 in the English language were
included in the study. Reports that were not in English language but had English abstracts with
adequate data for extraction were also included.

Results::

A total of 208 case reports and case series were included. The most reported drug classes
were antineoplastic and immunomodulating agents and anti-infectives for systemic use, and
the most common tongue disorders were tongue discoloration and black hairy tongue. Having
good oral hygiene and discontinuing the offending drug could manage and resolve the problem.

Conclusion::

Drug-induced tongue disorders are not rare adverse drug reactions. They are benign
in most cases, and withholding offending agents results in significant improvement or complete
resolution of tongue lesions.
Sildenafil Effect on Atrial Natriuretic Peptide Level in Pulmonary Hypertensive Rats
Authors: Aljanabi Mukhallad A. , Alrabadi Nasr , Mahmoud Sahar H. , Haddad Razan , Alzoubi Karem H.
Published: May 2024

Background:

Pulmonary Hypertension (PH) leads to changes in pulmonary vascular
architecture, hypertrophy of the right ventricle, and heart failure. Sildenafil is a drug that can
modulate PH by inducing smooth muscle relaxation and vasodilation.

Aims:

To investigate the ability of sildenafil to alleviate the monocritaline (MCT)-induced PH in
rats and to estimate the role and its effect on the atrial natriuretic peptide (ANP) levels.

Methods:

28 adult male rats were divided randomly into four groups: Group A (control group;
n=7). Group B (MCT-treated group; n=7) was given a single dose of MCT 60 mg/kg subcutaneously.
Group C (The reversal group; n=7) received a single dose of MCT 60 mg/kg subcutaneously
for three weeks and then sildenafil at 50 mg/kg/day, given daily for another three weeks.
Group D (The prevention group; n=7) simultaneously received a single dose of MCT 60 mg/kg
subcutaneously and sildenafil daily at 50 mg/kg for three weeks.

Results:

The animals in the prevention group showed a significant decrease in ANP levels compared
to the reversal and MCT-treated groups. This decrease was associated with a significant
reduction in the Fulton index ratio in the prevention group compared to the reversal group. The
nitric oxide levels were also significantly higher in the reversal group than in the control group.

Conclusion:

Preventive sildenafil treatment was associated with a significant decrease in ANP
levels and reduced MCT-induced cardiac hypertrophy in rats.
Experimental Study of Interference in Calcitonin Testing: A Case Report and Literature Review
Authors: Zhang Xiaofang , Liu Yixian , Liu Xiaoxuan , Shu Hua , Dong Zuoliang
Published: May 2024

Background:

Calcitonin (CT) is a sensitive serum marker of medullary thyroid carcinoma
usually detected via immunoassays; however, its levels are easily disturbed by several
endogenous factors.

Objective:

The study aimed to discuss a case of suspected interference resulting in aberrant CT
values and review previous reports of CT interference.

Methods:

A female patient visited our clinic with a physical ultrasound examination showing a
slightly enlarged thyroid gland with small nodules. She had elevated CT levels, inconsistent
with the clinical presentation and other findings. We evaluated the results by retesting using the
same platform, platform validation, multiplex dilution, Polyethylene Glycol (PEG) precipitation,
heterophilic blocking tubes, and RET gene analysis.

Results:

Retesting CT using the same platform confirmed the high value obtained. However,
serial dilution of the sample produced nonlinear results, suggesting some interference. While
PEG precipitation did not significantly reduce the CT level, incubating the sample in HBTs
normalized the CT value, indicating interference from heterophilic antibodies. Gene sequencing
revealed no RET mutations.

Conclusion:

In cases where elevated CT levels are inconsistent with clinical presentations and
other findings, the laboratory technicians should communicate with clinicians, analyze the reasons
for the inconsistent results, and use different methods to verify the results. Accurate testing provides
realistic and reliable data for doctors and patients and helps to avoid unnecessary procedures.
Solid Lipid Nanoparticles: A Review of their Biomedical Applications and Preparation
Authors: Jana Mayukh , Biswas Ujjwal Kumar , Patra Chandra Sekhar , Debnath Biplab , Sharma Suraj , Naskar Sweet
Published: May 2024

Solid lipid nanoparticles (SLNs) are gaining significant attention in the pharmaceutical
industry due to their biocompatibility and biodegradability, making them a popular functional
nanocarrier. SLNs are a popular nanocarrier due to their ability to bypass the spleen and liver, offer
high drug stability, and improve bioavailability, sterilization, immobilization, targeted drug release,
and biocompatible ingredients. This article discusses various SLN preparation techniques, including
high shear homogenization, hot homogenization, cold homogenization, microemulsion-based, solvent
evaporation, solvent emulsification-evaporation, supercritical fluid-based, spray drying, double
emulsion, and precipitation techniques, focusing on methodological aspects. This review discusses
the physicochemical behavior of SLNs, including drug loading, release, particle size, stability, cytotoxicity,
and cellular uptake, and their major biomedical applications.
Control Strategy and Parameter Optimization of Hybrid Vehicle Drive System
Authors: Li Penghui , Chen Guoqiang , Kang Jianli , Guo Desui , Kang Jincan
Published: May 2024

Background:

Pure electric vehicles still have the problem with range anxiety, but hybrid
vehicles can solve this problem well. Parameter optimization and adaptation of control strategies
are the keys to improving the economy of hybrid vehicles.

Objective:

This study aimed to improve the economy of hybrid vehicles to get more mileage in the
same working conditions. On the basis of a large number of invention patents, this study establishes
and optimizes the parameters and control strategy of hybrid vehicles in order to obtain better driving
parameters and a more appropriate control strategy for hybrid vehicle drive system.

Methods:

The key parameters of each component of the drive system are defined under dynamic
objectives of hybrid vehicles. The control strategy adopts a logic gate-based approach to determine
driving mode and braking of hybrid vehicles by limiting the speed, SOC, and power demand. Finally,
the particle swarm optimization algorithm is used to optimize the key parameters to obtain the
economic optimal solution without losing the vehicle power.

Results:

In the China light-duty vehicle test cycle-passenger (CLTC-P) cycle condition, the optimized
parameters can improve the fuel economy of fuel economy by 16.06%, and in the worldwide
harmonized light vehicles test cycle (WLTC) cycle condition, the optimized parameters can improve
the fuel economy of hybrid vehicles by 12.17%.

Conclusion:

By establishing and optimizing driving system parameters and control strategy of the
hybrid vehicles, this study improves the economy and achieves the expected effect without losing
the vehicle power. However, in further research, driving conditions and mileage under different
working conditions should be further studied, and on this basis, the optimization of control strategies
should be continued.
Methods for the Encapsulation of Hydrophilic Drugs in Lipid-Based Nanocarriers, Solid Lipid Nanoparticles, and Nanostructured Lipid Carriers: A Short Review and Perspective
Authors: Singh Amit Kumar , Kumar Manish , Upadhyay Prabhat Kumar
Published: May 2024

Hydrophilic drugs are proficient therapeutic drug candidates; however, their effective
delivery poses a formidable challenge. Therefore, the development of an efficient drug delivery
system demands a multifaceted approach. In recent decades, nanolipid carriers have emerged as
promising drug delivery systems, offering enhanced stability, improved bioavailability, and controlled
release profiles. Although nanolipid carriers have been widely investigated as carriers for
hydrophobic drugs and have demonstrated remarkable success in encapsulating hydrophobic
drugs, encapsulating a hydrophilic drug moiety still remains a challenge.
The current study provides a comprehensive review of innovative methods developed for the successful
encapsulation of hydrophilic drugs into nanolipid carriers. The first section of the study explores
the physicochemical properties of hydrophilic drugs and the inherent challenges associated
with their encapsulation in lipid-based carriers. The subsequent sections delve into the various
strategies employed to overcome these challenges. Emphasis is placed on novel formulation techniques
investigated for the encapsulation of hydrophilic drugs into nano lipid carriers. The present
review not only delineates the various traditional methods for high entrapment of hydrophilic
drugs but also underscores modifications to the hydrophilic drug candidates, facilitating their efficient
encapsulation into nanolipid carrier drug carriers.
This study explores the current state of knowledge regarding methods for encapsulating hydrophilic
drugs into nanolipid carriers. By addressing the challenges associated with hydrophilic drug encapsulation
and presenting innovative strategies, this review aims to provide valuable insights to
researchers and pharmaceutical scientists working in the field of nanomedicine and drug delivery.
Paramedic Mental Workload in Pandemic Covid-19 Era
Authors: Arifianto Dedy , Fitriasari Nikma , Mastuti Ni Luh Putu Herli
Published: May 2024

The number of Covid-19 patients hospitalized continues to increase in line with the increase in Covid-19 cases in Indonesia. The increasing number of Covid-19 patients in hospitals is increasing the workload of paramedics. High workloads will cause saturation and fatigue. In addition, an increase in the number of Covid-19 patients increases anxiety and depression will be infected when treating patients. Paramedics should also use personal protective equipment during shift guards which causes dehydration and discomfort. This situation can degrade the quality of service to patients. The study aims to measure the mental workload of paramedics by NASA-TLX (National Aeronautics and Space Administration Task Load Index) method and find out the factors that affect mental workload levels. This research is a quantitative research with a cross sectional approach. The research was conducted at Hospital X type C in Malang Regency in October 2020. The samples used were all 100 Hospital X paramedics. Research instruments in the form of questionnaires shared through Google Form. Data analysis is done with descriptive analysis and Chi-Square analysis with p value <0.05. The results found paramedics had a low mental workload of 1%, a moderate mental load of 3%, a high mental workload of 47%, and a very high mental workload of 49%. The Chi-Square test results found that age factors had an effect on the mental workload level of paramedics.
Solutions to Overcome Burnout Symptoms in Nurses in the Covid-19 Isolation Room
Authors: Kurniawan Sylvia Jessy , Gede Utara Hartawan I Gusti Agung , Rusca Putra Kuswantoro
Published: May 2024

The Covid-19 pandemic has left healthcare workers working in uncertain and stressful situations to care for all patients with disabilities. The second wave of the Covid-19 pandemic that swept across the world caused many nurses in health facilities to experience fatigue in carrying out their duties. This study aims to determine the cause of burnout symptoms in isolation room nurses in the Covid-19 pandemic. The study was conducted at X Hospital in September-October 2021. The design of this study was descriptive analysis. Observations were made on the service system, data, and environment of the Covid-19 isolation room at X Hospital. Interviews and discussions were conducted with the head nurse, the head of the occupational safety and health committee, and the head of nursing medical services related to nurse burnout in the isolation room. 67.74% experienced emotional exhaustion in the medium and high categories in isolation room nurses in the second wave of the Covid-19 pandemic caused by a lack of staffing. The solution to detect and overcome burnout is to conduct mental health checks and regular medical check-up programs for further treatment by considering the comfort factor and high functional value.
Analysis of Public Perceptions and Participation in Household Waste Management in the Working Area of Waste Management Technical Implementation Unit of Tumpang District Malang Regency
Authors: Roosa Lucy Cynthia
Published: May 2024

Population growth accompanied by activities in all fields affects the quantity and quality of waste produced. Community patterns and culture in managing waste currently still follow the old paradigm of collect-transport-dispose. This results in a buildup of waste which can shorten the life of the final landfill site (TPA) and impact the environment. Therefore, it is necessary to know the public's perception and participation in waste management to reduce the volume of waste. This research aims to determine and analyze the relationship between public perception and participation in household waste management. This research was conducted in the work area of the Waste Management Technical Implementation Unit, Tumpang District, Malang Regency. This research uses a quantitative approach supported by qualitative descriptive data collected through surveys and questionnaires. Based on research, it shows that the public's perception of household waste management is cumulatively positive and no negative perceptions were found. This means that there is no rejection from the community towards waste management efforts, but this positive perception is not supported by community participation.
A new dimension in learning badminton refereeing: A 3D simulation android app with virtual reality integration
Authors: Gazali Novri , Cendra Romi , Efendi Yoyon , Setiawan Edi , Medeirosd Alexandre Igor Araripe , Hamdi Liwa Ul
Published: May 2024

Virtual reality (VR) technology has become increasingly popular and widely used in sports environments in higher education, but there are still some challenges that need to be overcome. This research aims to create an Android-based 3D simulation application with the help of virtual reality as a learning tool for badminton refereeing. The methodology used is the Multimedia Development Life Cycle (MDLC). The multimedia development methodology consists of six stages, namely concept, design, material collection, creation, testing, and distribution. This application shows great potential for supporting the development of human resources in the field of badminton sports, both for novice referees and players. However, it should be noted that the current research is still at the application creation stage, with effectiveness and distribution tests still to be conducted. Through the optimisation of rendering techniques, test results show good simulation performance on smartphones with a resolution of 1920 x 1080, although the use of VR Box devices may cause eye fatigue in long-term use. This research makes an important contribution to the development of VR-based learning applications for badminton refereeing, with the hope of improving understanding and skills in sports and becoming the basis for the development of sports education technology. Future research should focus on completing the pending stages as well as expanding insights into user interaction and the positive impact that apps can have