bluuebunny/crossref_metadata_2025 huggingface dataset:
A global neuronopathic gaucher disease registry (GARDIAN): a patient-led initiative
Authors: Collin-Histed Tanya , Stoodley Madeline , Beusterien Kathleen , Elstein Deborah , Jaffe Dena H. , Revel-Vilk Shoshana , Davies Elin Haf ,   the International Gaucher Alliance (IGA)
Published: July 2023

Background

Gaucher disease (GD) is a rare autosomal recessive lysosomal storage disorder. GD types 2 and 3 are known as neuronopathic Gaucher disease (nGD) because they have brain involvement that progresses over time. Implementing a systematic approach to the collection of real-world clinical and patient-relevant outcomes data in nGD presents an opportunity to fill critical knowledge gaps and ultimately help healthcare providers in the management of this patient population. This paper summarizes the development of a patient-initiated Gaucher Registry for Development Innovation and Analysis of Neuronopathic Disease (GARDIAN).

Methods

The International Gaucher Alliance led the GARDIAN planning, including governance, scope, stakeholder involvement, platform, and reporting. Registry element input was determined in a series of meetings with clinical experts, patients, and caregivers, who identified key clinical variables and the draft content of nGD patient-reported outcomes (PRO) and observer-reported outcomes (ObsRO) focusing on symptoms, patient physical and emotional functioning. These were then tested in cognitive interviews with patients with nGD (> 12 years of age) and caregivers.

Results

Core registry data elements (n = 138) were identified by seven global clinical experts from Egypt, Germany, Israel, Japan, United Kingdom (UK), and United State (US) and reviewed via online Delphi method by 14 additional clinicians with experience of nGD from six countries and three pharmaceutical representatives. The elements were consistent with those identified via interviews with 10 patients/caregivers with nGD from Japan, Sweden, UK, and US. Key domains identified were demographics, diagnostic information, health status, clinical symptomatology, laboratory testing, treatment, healthcare resource utilization, aids/home improvements, and patient/caregiver burden and quality of life, specifically physical functioning, self-care, daily and social activities, emotional impacts, support services, and caregiver-specific impacts. Nine caregivers and six patients from the US, UK, China, Mexico, Egypt, and Japan participated in the cognitive interviews that informed revisions to ensure that all items are understandable and interpreted as intended.

Conclusions

The comprehensive set of clinical and patient relevant outcomes data, developed collaboratively among all stakeholders, to be reported using GARDIAN will bridge the many gaps in the understanding of nGD and align with regulatory frameworks on real-world data needs.
Success and complications in lumbar punctures of pediatric patients with leukemia: a study protocol for a randomized clinical crossover trial of a bioimpedance needle system versus conventional procedure
Authors: Sievänen Harri , Kari Juho , Aarnivala Henri , Becker Stefan , Huurre Anu , Långström Satu , Palmu Sauli
Published: July 2023

Background

Acute lymphoblastic leukemia (ALL) is the most common malignancy diagnosed in children. At present, the long-term survival from pediatric ALL is well over 90%. However, the probability of event-free survival is reduced if the lumbar puncture (LP) procedures at the beginning of the patient’s intrathecal therapy cause blood leakage into the spinal canal and blast cells contaminate the cerebrospinal fluid. According to the literature, such traumatic LP procedures concern one out of five pediatric patients with ALL.

Recently, a novel medical device measuring the tissue bioimpedance at the tip of a spinal needle was found feasible in pediatric patients with ALL. The LP procedure was successful at the first attempt in 80% of procedures, and the incidence of traumatic LPs was then 11%. The purpose of the present study is to compare the bioimpedance spinal needle system with the standard clinical practice resting on a conventional spinal needle and investigate its efficacy in clinical practice.

Methods

The study is a multicenter, randomized, two-arm crossover noninferiority trial of pediatric hemato-oncology patients that will be conducted within the usual clinical workflow. Patients’ LP procedures will be performed alternately either with the IQ-Tip system (study arm A) or a conventional Quincke-type 22G spinal needle (study arm B). For each enrolled patient, the order of procedures is randomly assigned either as ABAB or BABA. The total number of LP procedures will be at least 300, and the number of procedures per patient between two and four. After each study LP procedure, the performance will be recorded immediately, and 1-week diary-based and 4-week record-based follow-ups on symptoms, complications, and adverse events will be conducted thereafter. The main outcomes are the incidence of traumatic LP, first puncture success rate, and incidence of post-dural puncture headache.

Discussion

The present study will provide sound scientific evidence on the clinical benefit, performance, and safety of the novel bioimpedance spinal needle compared with the standard clinical practice of using conventional spinal needles in the LP procedures of pediatric patients with leukemia.

Trial registration

ISRCTN ISRCTN16161453. Registered on 8 July 2022.
Recombinant protein EBI3 attenuates Clonorchis sinensis-induced liver fibrosis by inhibiting hepatic stellate cell activation in mice
Authors: Zhao Lei , Li Jia , Mo Gang , Cao Deping , Li Chun , Huang Guoyang , Jiang Liping , Chen Gen , Yao Hongbing , Peng Xiaohong
Published: July 2023

Background

Chronic infection with Clonorchis sinensis can cause hepatobiliary fibrosis and even lead to hepatobiliary carcinoma. Epstein-Barr virus-induced gene 3 protein (EBI3) is a subunit of interleukin 35, which can regulate inflammatory response and the occurrence of fibrotic diseases. Previous studies have reported that the expression of EBI3 in the serum of patients with liver cirrhosis is reduced. The present study aims to investigate the biological effects of EBI3 on liver fibrosis caused by C. sinensis and the underlying molecular mechanisms.

Methods

We first established a mouse model of liver fibrosis induced by C. sinensis infection and then measured the serum expression of EBI3 during the inflammatory and fibrotic phase. GO (Gene Ontology) and KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway analyses were performed to investigate the potential role of EBI3 in liver fibrosis by regulating the extracellular matrix structural constituent and collagen catabolic process. Recombinant protein EBI3 (rEBI3) was added to hepatic stellate cells (HSCs) in vitro with C. sinensis antigen to explore its function. Finally, the therapeutic effect of rEBI3 was verified by intravenous injection into C. sinensis-infected mice.

Results

The results showed that the serum expression of EBI3 increased in the inflammatory response phase but decreased in the fibrotic phase. The excretory-secretory products of C. sinensis (Cs.ESP) were able to stimulate HSC activation, while rEBI3 reduced the activation of HSCs induced by Cs.ESP. Also, the protein expression of gp130 and downstream protein expressions of JAK1, p-JAK1, STAT3 and p-STAT3 in HSCs were increased after rEBI3 incubation. Finally, intravenously injected rEBI3 inhibited hepatic epithelial-mesenchymal transition in C. sinensis-infected mice by inhibiting HSC activation and reducing liver injury.

Conclusion

This study confirms that rEBI3 can attenuate C. sinensis-induced liver fibrosis by inhibiting HSC activation and may be one of the potential treatments for liver fibrosis.

Graphical Abstract
Left ventricular remodeling in rheumatoid arthritis patients without clinical heart failure
Authors: Park Elizabeth , Ito Kazato , Depender Christopher , Giles Jon T. , Bathon Joan
Published: July 2023

Rheumatoid arthritis (RA) patients have a 1.5- to twofold higher risk of developing heart failure (HF) and a twofold increased risk of HF-associated mortality compared to those without RA. HF is preceded subclinically by left ventricular (LV) remodeling in the general population. There is a relative absence of prospective studies following RA patients from pre-clinical to clinical HF as well as prospective studies of LV remodeling in RA without clinical HF. In our study, 158 RA patients without clinical HF were enrolled and underwent transthoracic echocardiography (TTE) at baseline and on follow-up between 4 and 6 years. Extensive characterization of RA disease activity and cardiovascular risk factors were performed. LV remodeling was prevalent at 40% at baseline and increased to 60% over time. Higher levels of interleukin-6 (IL 6) were associated with concentric LV remodeling on follow-up. The use of tocilizumab was also significantly associated with baseline LV remodeling (relative wall thickness). These findings suggest a role for IL-6 as a biomarker for LV remodeling in RA patients without clinical HF. Future research should focus on prospective follow-up of LV remodeling and the effects of IL-6 inhibition on LV remodeling in RA patients.
Sleep quality and clinical association with sleep disturbance in systemic sclerosis
Authors: Wongthawa Nonthaphorn , So-gnern Apichart , Mahakkanukrauh Ajanee , Suwannaroj Siraphop , Foocharoen Chingching
Published: July 2023

Background

Poor sleep quality is a common and potentially debilitating problem in systemic sclerosis (SSc). To date, no data clarifies the potential factors related to poor sleep quality and the clinical associations with sleep disturbance among Thais with SSc—mainly the diffuse cutaneous SSc (dcSSc) subset. We aimed to evaluate sleep quality and identify the clinical association with sleep disturbance among SSc patients.

Methods

A cross-sectional study was conducted between May 2021 and September 2021. Adult SSc patients were enrolled at the Scleroderma Clinic, Khon Kaen University, Thailand. All patients had their neck circumference measured, underwent airway evaluation using the Mallampati classification, had sleep quality assessed using the Pittsburgh Sleep Quality Index (PSQI), and the Berlin and Patient Health Questionnaire-9 completed. In addition, the clinical association with poor sleep quality (or sleep disturbance) was investigated using the PSQI.

Results

A total of 88 patients were enrolled. Forty-eight (54.6%) patients experienced poor sleep quality (95%CI 43.6–65.2). Digital ulcers and dyspepsia were associated with poor sleep quality as per a logistic regression (OR 10.73: 95%CI 1.09–106.15 and 4.60: 95%CI 1.01–20.89), respectively. Overall pain—evaluated using the visual analog scale (VAS)—was positively correlated with the PSQI score (Rho 0.2586; p = 0.02).

Conclusion

Around half of the SSc patients reported poor sleep quality, and the significantly associated factors were digital ulcers and dyspepsia. The PSQI scores positively correlated with overall pain as evaluated by VAS. With early assessment and treatment of digital ulcers, stomach symptoms, and pain control, sleep problems might be reduced among SSc patients.
Kerr-lens mode-locked 49-fs Tm3+:YScO3 single-crystal laser at 2.1 µm
Authors: Suzuki Anna , Kalusniak Sascha , Ganschow Steffen , Kränkel Christian , Tokurakawa Masaki
Published: July 2023

We report on a continuous wave (CW) and Kerr-lens mode-locked (KLM) Tm3+:YScO3 single-crystal laser centered at 2.1 µm. Efficient CW laser operation with a maximum slope efficiency of 51% was achieved under in-band pumping by an Er:Yb fiber master oscillator power amplifier (MOPA). In KLM operation, pulses as short as 49 fs corresponding to seven optical cycles were achieved at a repetition rate of 96.7 MHz with an average output power of 126 mW. Such short pulse durations are enabled by the inhomogeneously broadened emission spectrum of Tm3+:YScO3 extending to above 2200 nm.
Highly efficient CRISPR-mediated gene editing in a rotifer
Authors: Feng Haiyang , Bavister Gemma , Gribble Kristin E. , Mark Welch David B.
Published: July 2023

Rotifers have been studied in the laboratory and field for over 100 years in investigations of microevolution, ecological dynamics, and ecotoxicology. In recent years, rotifers have emerged as a model system for modern studies of the molecular mechanisms of genome evolution, development, DNA repair, aging, life history strategy, and desiccation tolerance. However, a lack of gene editing tools and transgenic strains has limited the ability to link genotype to phenotype and dissect molecular mechanisms. To facilitate genetic manipulation and the creation of reporter lines in rotifers, we developed a protocol for highly efficient, transgenerational, CRISPR-mediated gene editing in the monogonont rotifer Brachionus manjavacas by microinjection of Cas9 protein and synthetic single-guide RNA into the vitellaria of young amictic (asexual) females. To demonstrate the efficacy of the method, we created knockout mutants of the developmental gene vasa and the DNA mismatch repair gene mlh3. More than half of mothers survived injection and produced offspring. Genotyping these offspring and successive generations revealed that most carried at least 1 CRISPR-induced mutation, with many apparently mutated at both alleles. In addition, we achieved precise CRISPR-mediated knock-in of a stop codon cassette in the mlh3 locus, with half of injected mothers producing F2 offspring with an insertion of the cassette. Thus, this protocol produces knockout and knock-in CRISPR/Cas9 editing with high efficiency, to further advance rotifers as a model system for biological discovery.
Burnout: A predictor of oral health impact profile among Nigerian early career doctors
Authors: Ogunsuji Oluwaseyi Oyekunle , Adebayo Oladimeji , Kanmodi Kehinde Kazeem , Fagbule Omotayo Francis , Adeniyi Adebayo Makinde , James Nuhu Teri , Yahya Abdulmajid Ibrahim , Salihu Mumeen Olaitan , Babarinde Tosin , Olaopa Olusegun , Selowo Temitope , Enebeli Ugo Uwadiako , Ishaya Dare Godiya
Published: July 2023

There have been reported association of oral health disorders with burnout, stress, and mental health. Arguably, with these reported associations, and the current prevalence of burnout amongst Nigerian doctors, exploring the role of burnout on oral health amongst Nigerian doctors is timely. This study aims to determine the relationship between burnout and oral health-related quality of life amongst Early Career Doctors (ECDs) in Nigeria, while also identifying the role other possible predictors plays in this relationship. This was a cross-sectional study conducted amongst Nigerian ECDs as part of Challenges of Residency Training in Nigeria (CHARTING) II project. A total of 632 ECDs were recruited across thirty-one tertiary hospitals in the 6 geopolitical zones of the country using a multistage cluster sampling technique. A self-administered paper-based semi-structured questionnaire was given to each participant that consented. The tools used to assess burnout and Oral health-related quality of life (OHRQoL) were Copenhagen Burnout Inventory (CBI) and Oral Health Impact Profile (OHIP-14) respectively. Independent samples T-test, ANOVA and Multiple linear regression were used to draw inferences from the data collected. Overall mean OHIP-14 score of all participants was 11.12 (±9.23). The scores for the 3 dimensions of burnout were below 50% with CBI-Personal Burnout having the highest score of 49.96 (±19.15). Significant positive correlations (p < 0.001) were found between OHIP-14 and all the dimensions of burnout, as the burnout scores were increasing, there was a corresponding increase in the OHIP scores thus poorer OHRQoL. The regression model shows that the predictors of OHIP were CBI-PB (p = 0.003), use of fluoride paste (p = 0.039), use of tobacco (p = 0.005) and being a denture user (p = 0.047). This study shows a positive correlation between burnout and OHIP of ECDs. We found that as burnout was increasing, OHIP increased thus implying poorer oral health related quality of life amongst ECDs. The use of fluoride toothpaste, tobacco and denture are other factors we found that could affect the OHIP of ECDs.
Distinctive transnational city-to-city partnerships, decentralization, and local governance of China as a Global East Country
Authors: Xu Jili , Liu Huaikuan , Huang Gengzhi
Published: July 2023

Against the background of globalisation and state rescaling, promoting decentralisation and enhancing local governance capacity have become prioritised objectives of transnational city-to-city partnerships mainly between developed and developing countries. However, considering the critical debates on Global East’s uniqueness, two questions emerge when studying the transnational partnerships of Chinese cities. (1) Are Chinese cities’ partnership establishments and objectives remarkably different from the existing international body of knowledge? (2) In China, whether decentralisation and local governance are promoted by city-to-city transnational partnerships as well? To cope with the questions, this paper examines 28 Chinese world cities’ partnership establishments and objectives and reaches two conclusions. (1) With the objective of economic development, Chinese cities have consistently maintained strong connections with cities in both the developed and developing countries. (2) Chinese cities’ transnational partnerships do not observably promote decentralisation, and China’s political decentralisation is much more unstable than its economic decentralisation. Overall, both the binary partnership establishments and the dual-track decentralisation in political and economic aspects are highly embedded in China’s interstitial and transitional position as a Global East country.
Teodorín Situation (Part I)
Authors: Martino Martin Enrique
Published: July 2023

The essay is divided and published into two parts: each separately assessing the main recent trends in the national and international politics of Equatorial Guinea — roughly between the Covid-19 crisis and May 2023. Part I profiles the current vice president, Teodoro Nguema Obiang Mangue, widely known by his moniker Teodorín. His dynastic succession seems practically set in stone and quite imminent, given that his father, the president, Teodoro Obiang Nguema Mbasogo, is an octogenarian and has recently shown many signs of an already effectively retired. Part I focuses on Teodorín’s populist policy style, the demotion and persecution of contenders, and the punishment of anti-government figures both within and outside the country, which have served to display and consolidate his domestic ascension to power. The combined introduction in part I, and the conclusion in part II outlines the recent shifts across the domestic political, international geopolitical, and economic domains, that have marked and steered Teodorín’s active and seemingly inevitable rise to the presidency of Equatorial Guinea.
HUBUNGAN ANTARA KEPRIBADIAN EXTRAVERSION DENGAN ORGANIZATIONAL CITIZENSHIP BEHAVIOR (OCB) PADA SATPAM OUTSOURCING DI UNIVERSITAS DIPONEGORO
Authors: Rachmawati Annisa , Indrawati Endang Sri
Published: July 2023

Penelitian ini bertujuan untuk mengetahui hubungan antara kepribadian extraversion dengan organizational citizenship behavior (OCB) pada satpam outsourcing di Universitas Diponegoro. Organizational citizenship behavior (OCB) adalah perilaku sukarela individu yang melampaui interpretasi persyaratan pekerjaan dan tidak mengklaim imbalan jasa dari sistem penghargaan formal serta dapat meningkatkan fungsi organisasi secara efektif. Kepribadian extraversion merupakan kemampuan individu dalam bersosialisasi, beraktivitas, dan kecenderungan untuk mengalami emosi positif seperti kebahagiaan. Populasi penelitian ini berjumlah 82 satpam outsourcing di Kantor Pusat Universitas Diponegoro Semarang dengan sampel sebanyak 45 satpam outsourcing yang dipilih melalui teknik simple random sampling. Pengumpulan data menggunakan skala kepribadian extraversion (29 aitem, a = 0,907), dan skala organizational citizenship behavior (24 aitem, a = 0,939). Metode analisis data menggunakan analisis non-parametrik dengan Spearman’s Rho. Berdasarkan analisis data menggunakan Spearman’s Rho dapat diketahui bahwa nilai koefisien rxy = 0,223 dengan nilai signifikansi sebesar p = 0,14 (p>0,05). Hasil analisis tersebut menunjukkan bahwa tidak ada hubungan yang signifikan antara kepribadian extraversion dengan organizational citizenship behavior (OCB), artinya semakin tinggi atau rendah OCB yang dimiliki satpam outsourcing di Universitas Diponegoro Semarang tidak dapat diprediksi melalui kepribadian extraversion.
Bayesian inference for non-anonymous growth incidence curves using Bernstein polynomials: an application to academic wage dynamics
Authors: Fourrier-Nicolaï Edwin , Lubrano Michel
Published: July 2023

The paper examines the question of non-anonymous Growth Incidence Curves (na-GIC) from a Bayesian inferential point of view. Building on the notion of conditional quantiles of Barnett (1976. “The Ordering of Multivariate Data.” Journal of the Royal Statistical Society: Series A 139: 318–55), we show that removing the anonymity axiom leads to a complex and shaky curve that has to be smoothed, using a non-parametric approach. We opted for a Bayesian approach using Bernstein polynomials which provides confidence intervals, tests and a simple way to compare two na-GICs. The methodology is applied to examine wage dynamics in a US university with a particular attention devoted to unbundling and anti-discrimination policies. Our findings are the detection of wage scale compression for higher quantiles for all academics and an apparent pro-female wage increase compared to males. But this pro-female policy works only for academics and not for the para-academics categories created by the unbundling policy.
Household availability of foods from Brazilian biodiversity
Authors: Silva Marcos Anderson Lucas da , Rodrigues Lucas Braga , Domene Semíramis Martins Álvares , Louzada Maria Laura da Costa
Published: July 2023

Abstract: Food biodiversity is characterized by the diversity of foods that compose a local, regional, or national ecosystem. Brazil has 20% of all the planet’s biodiversity and the richest biomes in the world. Therefore, describing the participation of these foods in the Brazilian diet is relevant. Using a complex sample with data from 57,920 households collected by the Brazilian Institute of Geography and Statistics from 2017 to 2018, this study showed that, except for yerba mate, the availability of foods from Brazilian biodiversity is low, representing an average of 7.09g/per capita/day. Regarding biomes, the Caatinga had the highest availability of fruits (4.20g/per capita/day) while the Amazon had the highest availability of vegetables (1.52g/per capita/day). The results are unsatisfactory and lower than what is expected from a territory rich in biodiversity and a world-leading food system. A greater commitment is essential to promote actions that strengthen the consumption of these foods among Brazilians.
READING BEFORE AND AFTER RETIREMENT: SOCIAL REPRESENTATIONS AND PRACTICES OF TEACHERS
Authors: OLIVEIRA NETO ANTÔNIO DURÃES DE , VELOSO GEISA MAGELA
Published: July 2023

ABSTRACT: This article discusses the constitution of the practices and social representations of reading of retired teachers, mapping the processes and functions of reading before and after retirement. For this, qualitative research was carried out with the participation of 55 teachers. In the literature review, we used the studies of Batista (1998), Britto (1998), Corsino (2010), Guareschi (1995), Moscovici (1978; 2015), and Zilberman (1999). In light of Serge Moscovici’s (1978) studies on the Theory of Social Representations, we found that during the trajectories lived, there were changes related to the purpose of the reading practices. In childhood and adolescence, the social representations of reading were built in the context of the absence of books and reading and in the attitudes linked to the encouragement and practice directed at the family and school. In adulthood, before retirement, reading had an obligatory character, seen as fundamental for teaching in the classroom. After retirement, the reading practices of female teachers take on new contours and are based on their interests, meaning they read what they want and when they want, without the imposition of reading to meet a professional need.
PEDAGOGICAL FORMATION IN DIALOGICAL LEARNING: CONTRIBUTIONS TO TEACHER TRAINING IN TIMES OF SOCIAL DISTANCING
Authors: SILVA VIVIAN MASSULLO , BRAGA FABIANA MARINI , CARVALHO AMANDA DE , MOREIRA RAQUEL
Published: July 2023

ABSTRACT This article presents the results of the research developed from the course of Dialogical Learning formation, offered remotely during the social distancing period caused by the COVID-19 pandemic, and focused specifically on the teacher training. The research was carried out through an electronic form filled by participants, as well as reports and a communicative focused group, all performed after the course’s end. The aim was to understand the impact of the course in Dialogical Learning formation on educators’ theoretical and practical knowledge and its relation to facing social isolation. Based on the theoretical basis of the Communicative Methodology, the answers obtained were listed as transforming elements and excluding elements according to their contributions to the course of educators’ formation and the pandemic facing. As result, we highlight the instrumental dimension, the necessity of ensuring the teacher training based on scientific evidence, and the creation of sense as transforming elements. Data also reveal that a lack of dialog and a vertical structure in teaching systems promote distance between teaching practices and better educational results. The elements pointed out as transforming provided support for the participants to look for answers to the issues they faced in their everyday routines, both in professional and personal contexts. We hope this article may contribute to the teacher training, therefore promoting reflection on the necessity of aligning this formation with studies produced by the international scientific community.
Impact of the fall armyworm, Spodoptera frugiperda (Lepidoptera: Noctuidae) infestation on maize growth characteristics and yield loss
Authors: Bakry M. M. S. , Abdel-Baky Nagdy F.
Published: July 2023

Abstract The fall armyworm [FAW; Spodoptera frugiperda (J.E Smith, 1797)] is an invasive and polyphagous insect that infests cereal crops, causing economic losses, and may be led to pose a threat to future the global maize crop in the future. Field trials were conducted to study the negative impacts of S. frugiperda on vegetative growth measurements, yield, and the components of the maize cultivar (Single-Hybrid 168 Yellow) in Luxor Governorate, Egypt. S. frugiperda larvae infestation to maize plants was observed in the 3rd week of June and so continued till the harvest in both 2021 and 2022 seasons. S. frugiperda had three peaks of the seasonal activity/season in the untreated (pesticide-free, control) and in the treated main plots by pesticides. Maize vegetative growth attributes (averages of plant height, stem diameter, and the number of green leaves per plant) displayed higher rates of the treated maize plants by insecticides against S. frugiperda. Maize grain, straw, and biological yield (kg/ha) were decreased in the untreated maize plants (insecticides free) than in the treated by insecticides. Concerning maize yield components, the treated plants were to outperform in the average length of a plant stem (cm), stem diameter (cm), and weight of cob (g), as well as, number of rows/cob, number of grains/ cob, number of grains/cob, maize cob grain weight (g) and weight of 1000-grains (g)], in comparison with the untreated plants. Also, the FAW infestation to untreated maize plants was decreased well in all calculated maize growth attributes, i.e., grain yield, and components. Regarding the relationship between variations in a given variable and the changes in S. frugiperda larvae numbers and plant damage percentage, the simple correlation and regression coefficient revealed a highly significant negative relationship in all the parameters tested. The obtained information may help farmers and decision-makers in the management of FAW populations based on an effective plan related to control measures that should be implemented.
Taxa de oclusão em veias safenas pós-endolaser de 1.470 nm e efeitos colaterais no seguimento de 1 ano
Authors: Movio Leonardo Zelotti , Mansano Marco Antônio Forastieri , Zanoni Marcelo Eckert , Silva Nancy Christiane Ferreira , Rangel Marcel Pereira
Published: July 2023

Resumo Contexto O uso do endolaser para doença venosa crônica envolve a escolha do comprimento de onda, fibra óptica e energia dispensada. Sua eficácia é avaliada pela taxa de oclusão venosa e, a segurança, pelos efeitos colaterais. Objetivos Demonstrar a incidência de oclusões venosas totais de veias safenas pós-endolaser no seguimento de 1 ano. Descrever a incidência e os efeitos colaterais e a necessidade de reintervenção ou complemento da terapêutica no pós-operatório. Métodos Estudo observacional retrospectivo de uma coorte com abordagem quantitativa de pacientes com insuficiência das veias safenas tratados com laser ablação endovenosa de 1.470 nm. Dados cadastrados em planilha MS Excel 2019, com cálculos de médias e desvios padrão pelo suplemento Power Query do Software. Resultados Foram elegíveis para o estudo 38 pacientes e 104 segmentos venosos, dos quais 100% estavam ocluídos em 30 dias e 99,04% em 1 ano pós-procedimento. O Linear Endovenous Energy Density médio para safena interna foi de 2.040,52 W/cm/s com desvio padrão ± 1.510,06 W/cm/s e 1.168,4 W/cm/s com desvio padrão de ± 665,011 W/cm/s para safena externa. Dor no trajeto da safena foi o principal efeito colateral, com oito casos (21,05%), seguido de parestesia, com um caso (2,63%). Conclusões Taxa de oclusão total no seguimento de 1 ano sugerindo técnica promissora e com atual aplicabilidade na amostra. A incidência da dor e parestesia podem ser justificadas pela alta média de energia utilizada em alguns casos. Recomenda-se a realização de estudos multicêntricos, com amostras maiores e mais homogêneas em relação à classificação Clínica-Etiológica-Anatômica-Patológica.
Muito além do negacionismo: desinformação durante a pandemia de Covid-19
Authors: Miskolci Richard
Published: July 2023

Resumo A análise de um arquivo formado por editoriais de dois dos mais importantes jornais brasileiros durante os dois primeiros anos da pandemia de Covid-19 identificou a predominância de um enquadramento que atribuiu as decisões do governo Bolsonaro ao negacionismo científico. A partir de fontes históricas e sociológicas, este artigo discute o que ficou de fora desse enquadramento normativo sobre ciência e saúde, em especial como a extrema-direita adaptou para o novo ecossistema midiático o uso do paradigma da desinformação criado por indústrias cancerígenas. O artigo conclui que o enquadramento jornalístico do negacionismo priorizou críticas à incompetência do Estado, dando menor visibilidade ao papel do Sistema Único de Saúde na urgência sanitária.
A sociedade mundial desde a periferia: a sociologia da exclusão de Marcelo Neves
Authors: Holmes Pablo , Dantas Maria Eduarda
Published: July 2023

Resumo O artigo apresenta uma interpretação da obra do sociólogo e constitucionalista Marcelo Neves como uma contribuição a uma reflexão sobre o processo de construção do Estado brasileiro desde uma perspectiva pós-colonial, não eurocêntrica. Para isso, apresentamos seu diálogo com a tradição sociológica brasileira representada no “paradigma da formação”. Argumentamos que Neves se afasta do nacionalismo metodológico dessa tradição, com críticas a seus pressupostos e funções ideológicas, mas aproveita algumas das observações sociológicas sobre as periferias descritas por essas teorias – como a infiltração de interesses privados sobre o público e a reprodução de relações sociais profundamente desiguais. Para Neves, a exclusão social surge como peça fundamental a estruturar uma ordem social estável e fundada em formas precárias de cidadania.
Bonecas sexuais: conexões colonizadoras entre fabulações, tecnologias e sexualidades
Authors: Montargil Gilmar
Published: July 2023

Resumo Em Sex Dolls at Sea: Imagined Histories of Sexual Technologies, Bo Ruberg assume a genealogia foucaultiana e a leitura feminista como método para esmiuçar a nebulosa intersecção entre fabulação, história e ciência que paira as dames de voyage. A partir de análise bibliográfica e investigação em arquivos, filmes, jornais, relatos e uma diversidade de outros documentos, a pesquisadora não só desvela práticas acadêmicas viciosas e misóginas no século XX e XXI, mas também, como o imaginário em torno das bonecas de viagem moldaram a indústria do mercado sexual a criar uma série de tecnologias sexuais como bonecas infláveis, vibradores e brinquedos de borracha. Nesse processo, o limiar entre bonecas, bonecas sexuais, “ser mulher”, profissional do sexo, santas, vai sendo borrado, modelizando visões de posse, uso, descarte, pureza às corporalidades feminilizadas, ao mesmo tempo em que narrativas e estruturas de poder masculinas, colonizadoras e eurocêntricas vão condicionando as práticas sexuais, o imaginário sobre o sexo e os produtos que consumimos. Os robôs sexuais são apresentados como o futuro, e, diante de uma sociedade solidificada em discursos que segregam mulheres, pessoas queer e negras do âmbito da produção e consumo de tecnologias, sobretudo as digitais, é importante desestabilizar essas narrativas dominantes, identificando como as tecnologias sexuais foram imaginadas e agenciam as práticas sociais contemporâneas, para que possamos produzir outras perspectivas para o futuro em que a inclusão e o prazer sejam centrais.
Satellites and the Changing Politics of Transparency in World Politics
Authors: Müller Thomas
Published: July 2023

This article explores the degree to which commercial satellite imagery has empowered non-state actors in the politics of transparency in world politics. This question has received renewed attention in the wake of the disclosure of China’s new missile silos in 2021 as well as Russia’s war against Ukraine since 2022. The article contributes to research on this question by teasing out the competition over authority undergirding the politics of transparency. It does so in two steps: it conceptualizes the politics of transparency as involving a combination of state and non-state actors engaging in transparency efforts against another state or other states and it distinguishes four aspects of the empowerment of non-state actors in such constellations of actors: (a) the emergence of new or better disclosure devices that (b) bolster the expertise of some non-state actors, (c) giving them more influence over public debates, and (d) prompting changes in the policies of relevant actors. The article uses this framework to explore the factors that affected the degree of empowerment of non-state actors in the two cases of China’s new missile silos as well as Russia’s war against Ukraine. It highlights three factors: the interplay between state and non-state transparency makers, the polarization of public spheres, and the ability of states targeted by the transparency efforts to fragment public spheres.
Análisis de la implementación de la tasa de registro de caninos potencialmente peligrosos en el departamento del Caquetá
Authors: Almario Ceballos Mayerlin , Restrepo Lizcano John Jairo , Sánchez Castillo Verenice
Published: July 2023

El objetivo de la presente investigación es analizar la implementación de la tasa de registro de caninos potencialmente peligrosos en el Departamento del Caquetá. Se realiza una investigación de tipo descriptivo, con un enfoque mixto, la información se recolectó por medio de encuesta y entrevista estructurada. Dentro de los resultados se tiene que a pesar de ser una medida tributaria que incentiva o desincentiva comportamientos ciudadanos frente a la tenencia de estos caninos de manejo especial, el 80,00% de los gobiernos subnacionales en el Caquetá conoce la tasa, y de éstos, sólo el 40,00% incluyeron la medida en sus estatutos tributarios y el resto aún no lo han hecho debido a lo reciente de la regulación o porque no se justifica su adopción por el tamaño reducido o mínimo de la población canina en los municipios. Finalmente, los hallazgos muestran que los antecedentes normativos permiten establecer las características de los caninos de manejo especial y la manera de concretar su identificación por medio de la tasa de registro establecida por el gobierno, no obstante, no ha tenido importancia en la población ni en las entidades públicas del departamento debido a su baja implementación. A manera de conclusiones, se evidencia la falta de compromiso de los gobiernos municipales para la incorporación de la tasa y el control de la población con caninos de manejo especial que permita verificar las acciones pertinentes para minimizar los eventos donde estén involucrados este tipo de caninos.
Connotations: a fragment of lexical meaning, its place in the model of language activity
Authors: Borisova Elena
Published: July 2023

The subject of the article is the notion of the so called connotations, that are determined as complementary fragments of lexical meanings. The article revealis the place of these units in the model of language aimed to reflect the speech activity (‘activity model of language’). Though the notion of connotations is rather common now there are difficulties with putting this notion in language models that are aimed to reflect the kernel of the lexical meaning: denotative or significative type. The amount of the phenomena varies in various theories: the evaluative and emotive information are called connotations by the majority of the linguists. While some other phenomena: associations, expressivity, registers of speech – are called connotations only by several researches. The most complicated problem is the specifics of connotational fragments and its difference from the denotative and significative fragments of meanings. The article analyses several types of connotations and describes some features of the models of language that can incorporate such notion as connotations.
Estudio mediante cuestionarios anónimos de las fallas en la integridad científica del personal de investigación latinoamericano, 2001-2020
Authors: Calzolari Aldo
Published: July 2023

El objetivo de este trabajo es analizar fallas a la integridad científica por parte de personal de investigación latinoamericano. Metodología: se realizaron cuestionarios anónimos y voluntarios después de trata este tema en 121 cursos de redacción científica/taller de tesis dictados en Latinoamérica, sobre todo en Argentina, durante 20 años (2001-2020). Resultados: l as 2064 r espuestas válidas mostraron que un 60 % tenía cinco o más años de egreso, 48,6 % señalaron coautoría indebida y 28,9 % que su nombre fue omitido de publicaciones. Un 24,9 % reconoció haber cometido alguna clase de mala conducta en su carrera. La coacción a que fue sometido para que lo hiciera fue reconocida por un 56,7 %. El 60,7 % de las 512 personas ignoraba que era un error. La coautoría indebida fue la mala conducta más frecuente (46 %), seguida de plagio y falseamiento de datos. En relatos conocidos de primera mano se destacan: publicación en salamín, duplicación y robo de datos, así como soborno y manipulación de imágenes. Ninguna de las personas que tomaron cursos previos de formación en bioética (0/560) cometieron motu propio actos inadecuados. Conclusión: el personal científico comete un porcentaje relativamente elevado de fallas a la integridad científica; impartir cursos de integridad científica tiene un fuerte rol en el autocontrol para evitarlas.
Mujeres en la casa sevillana (siglo XVI): análisis del mercado inmobiliario y estudio arquitectónico
Authors: Núñez-González María , Moya-Olmedo Pilar
Published: July 2023

Este artículo pretende destacar la importancia que tuvieron las mujeres en la arquitectura de las casas y el mercado inmobiliario en la ciudad de Sevilla, en España, en el siglo XVI. Estudiando más de un millar de apeos de casas de la Catedral y hospitales de caridad (informes detallados que incluían nombres de inquilinos, situación, distribución de espacios, dimensiones, construcción y estado de conservación) y analizando los edificios que describen, se ha podido concluir que la condición de género no siempre evidenció la ausencia de mujeres y que su influencia en la arquitectura fue considerable (un tercio de los arrendatarios eran mujeres de diferentes condiciones y escalas sociales, y el uso de estos inmuebles fue de lo más variado). Además, a partir de las recreaciones de viviendas se ha podido confirmar que definieron espacios propios en las casas, los denominados servicios de mujeres.
The rise of generative AI and possible effects on the economy
Authors: Orchard Tim , Tasiemski Leszek
Published: July 2023

The aim of the paper is to analyse the likely implications of Generative AI (GAI) on various aspects of business and the economy. Amid the rapid growth and maturing of Generative AI technologies such as Large Language Models (like ChatGPT by OpenAI) a rapid growth of both immediate and potential applications can be seen. The implications for the economy and industries of this technological shift will be discussed. The foreseeable scenarios for the level and types of adoption that GAI might achieve - from useful analytical tool, invaluable assistant to the white-collar workers of the world to being trusted with a wide array of business and life-critical decision making. Both disruptive and premium service opportunities are foreseen. For instance general purpose models may provide quality service – such as copywriting – to overserved customers leaving human writers as the premium option. In this context, overserved customers would be those who would be satisfied with a non-human, potentially less creative content. On the other hand highly specialized models – specifically trained in a given domain and with access to proprietary knowledge can possibly provide a premium service over that provided by human experts. It is expected that some jobs will be replaced by new AI applications. However new workplaces will emerge. Not only the obvious expert-level data scientist roles but also low grade, “model supervisors” – people training the models, assessing the quality of responses given and handling escalations. Lastly new cybercrime risks emerging from the rise of GAI are discussed.
“Hopeful feeling[s]:” Utopian Shakespeares and the 2021 Reopening of British Theatres
Authors: Hawkins Rowena
Published: July 2023

This article focuses on a specific moment in recent British theatre history: the late spring of 2021 when theatres reopened after a prolonged period of closure that had been enforced during the first waves of the Coronavirus pandemic. It considers The HandleBards’ production of Romeo and Juliet (performed at York’s Theatre Royal) and Shakespeare’s Globe Theatre’s production of A Midsummer Night’s Dream in the context of that unusual time. The productions, which both used bright colours and irreverent approaches to create festive atmospheres, had a shared joyful aesthetic which encouraged me to think more deeply about what audiences wanted—and needed—from post-lockdown theatre. In this article, I suggest that these vibrant Shakespeares, when presented in the immediate aftermath of the first waves of Covid, functioned as cathartic utopian performatives. They offered audiences uncomplicated joy and “a hopeful feeling of what the world might be like” after Coronavirus (Dolan 2005, p. 5). They “let audiences experience a processual, momentary feeling of affinity” and encouraged them to “imagine, together, the affective potential of a future in which this rich feeling of warmth, even of love, could be experienced regularly and effectively outside the theatre” (Dolan, p. 14). Utopian performatives are characterised by their transience and, inevitably, the simple joy of these Shakespeares was fleeting. Both venues have since hosted visually and thematically darker productions that have used Shakespeare to explore important social and political issues. Indeed, the HandleBards’ Romeo and Juliet and The Globe’s Midsummer are productions which might, in other circumstances, have been dismissed as simplistic. However, I suggest that these productions offered real hope for the future in the wake of crisis and demonstrate the importance of theatre in challenging times.
Utopia, Arcadia and the Forest of Arden
Authors: Paterson Ronan
Published: July 2023

In Utopia (1516) Thomas More created a humorous world with a serious purpose. His invented republic was a place where existing conventions and structures did not exist, allowing the positing of alternatives. The creation of alternative worlds which satirise or critique contemporary society is a technique employed by writers in most genres, in most periods and in most cultures. More’s work is interesting for us in this context at least in part because of the likelihood that Shakespeare was familiar with it. When he created The Forest of Arden in As You Like It, for some of the characters there are utopian elements in their experience of that place. But Arden is not only a putative Utopia. Arden also contains elements of the pastoral Arcadia, again drawing upon ancient precedents, but more recently explored by English poets Edmund Spenser in The Shepherd’s Calendar (1579) and Philip Sidney in The Countess of Pembroke’s Arcadia (1593). This article interrogates the use of Utopian and Arcadian elements in the creation of one of Shakespeare’s most complicated plays. Like More’s Utopia its intention is comic. Like Sidney’s poem it is romantic, but unlike both of them it is ultimately about returning to a real world, with new perceptions of who we are, not as a society but as individuals.
Bracia czescy w Kościele Ewangelicko-Reformowanym w Polsce – przeszłość i teraźniejszość
Authors: Szczepankiewicz-Battek Joanna
Published: July 2023

Artykuł prezentuje rozwój osadnictwa czeskich protestantów (luteranów oraz braci czeskich) na ziemiach polskich z perspektywy geografii historycznej; uwzględniono zarówno ziemie należące do Polski w przeszłości (np. Wołyń), jak i te włączone do niej dopiero po drugiej wojnie światowej (np. ziemię kłodzką). W artykule wyróżniono kilka zasadniczych etapów historycznych tego osadnictwa, jego lokalizację oraz przyczyny (polityczne oraz gospodarcze). Omówiono jego charakterystyczną morfologię (na podstawie pozostałych do dziś śladów w przestrzeni) oraz wpływ wyznania i kultury osadników na miejscową ludność. Podsumowaniem całości studium jest przedstawienie roli, jaką obecnie ludność pochodzenia czeskiego odgrywa w Kościele Ewangelicko-Reformowanym w Polsce.
Działalność społeczno-kulturalna mniejszości narodowych i religijnych w przestrzeni miejskiej Pabianic do drugiej wojny światowej
Authors: Rykała Andrzej
Published: July 2023

Mniejszości narodowe (głównie żydowska i niemiecka), tożsame na ogół z mniejszościowymi wspólnotami religijnymi, wniosły wymierny wkład w rozwój zarówno gospodarczy, jak i społeczno-kulturalny Pabianic. Głównym celem artykułu jest określenie charakteru i form organizowania w przestrzeni miejskiej aktywności społeczno-kulturalnej przez wymienione grupy.