bluuebunny/crossref_metadata_2025 huggingface dataset:
A crise ambiental e a ecologização do capital em uma leitura marxista
Authors: Monerat Julio Cesar Pereira
Published: February 2022

O artigo desenvolve o conceito de ecologização do capital a partir do referencial teórico marxiano, definindo-a como forma capitalista de enfrentamento da crise ambiental que é causada pelo próprio movimento do capital. Inicia-se relacionando a crise ambiental e a dinâmica necessariamente expansiva do capital referenciada na categoria valor. Essa dinâmica expansiva tem sua complexidade destacada, na sequência, pelo estudo da renda fundiária, quando se verifica o caráter desigual e combinado da expansão capitalista sobre o ambiente. O artigo realiza, em seguida, um paralelo analítico entre a crise ambiental e a crise do capital relacionada ao valor, identificando o caráter tendencial das crises no capitalismo e seu fundamento na eliminação proporcional do trabalho vivo em relação ao trabalho objetivado. A análise dos elementos da crise ambiental – relacionados ao estudo prévio da renda fundiária e à dinâmica expansiva do capital sobre a natureza – permite identificar que, na crise ambiental, atuam contratendências e, mais do que isso – o que revela uma contribuição analítica importante para o debate ambiental no marxismo –, que a ecologização do capital tem a potencialidade de atuar ela mesma como uma tendência contra-arrestante à crise capitalista ao converter obstáculos ambientais em fronteiras para a expansão do capital.
As artes como elementos facilitadores da integração sociocultural de migrantes e refugiados
Authors: Silva Rayna Sargem da , Neves Roberta  Alves Guimarães das , Inácio Vitor Belém
Published: February 2022

Objetiva-se analisar de que maneira as artes podem atuar como elementos integradores do público migrante e refugiado às instâncias socioculturais em seu país de acolhimento. A partir do crescimento do fenômeno migratório no mundo durante as duas últimas décadas, é reconhecida a necessidade de que esses estrangeiros consigam obter uma plena inclusão no novo país. Nesse contexto, compreendendo as artes como uma realidade social, discute-se como elas constituem instrumentos de diálogo em realidades culturais díspares. Além disso, propõe-se que a valorização de uma sociedade plural, pautada pelo multiculturalismo emancipatório, capaz de abarcar e respeitar as diversas dimensões culturais existentes em um mesmo local, possa ser o caminho para o combate à xenofobia aos migrantes.
Analysis Of Social Structure And Power Relations In NW Anjani Community
Authors: Parhanudin Muh. Alwi
Published: February 2022

In Political Sociological perspective, Nahdlatul Wathan is not only present in religious narration of Sasak Community but also has been able to build social structure with certain typical characteristics. Putting Islamic fundamentals, nationality, and NW-ism, the social structure of NW citizens reflects more the communal community, the one with high social interaction intensity and religious character. In its development, the dynamics of Nahdlatul Wathan community in communal dimension reflects a complex power relation, not only in “piety” classification and teacher-student relation but also shifting to education and intellectuality levels, resource ownership, family hegemony, and territorial egocentrism. This article will address the interaction pattern built within NW Anjani-affiliated community and power relation developing within it. This study employed structural-functional theory to read structure and system running, and power-relations theory to read the power developing in the social structure. This study describes that NW Anjani has a variety of basic values remaining to be held on tightly by its citizen as social capital and social interaction glue. The dynamics of NW Anjani community also reveals strong and functional power relation and gives significant implication to the citizen community wholeness. However, the shift of paradigm and social action of most NW Anjani citizens remains to be apparent from communal toward-non communal community, and from authoritative power relation toward symbolic authority resistance.
Amiloidose fora de centros especializados: a identificação é possível?
Authors: Cracco Luiz Augusto Fanhani , Silva Isabela Busto , Lessa Junior Edson Marcos Campos , Marques Gustavo Lenci , Vinholi Giovanna
Published: February 2022

Objetivos: relatar a experiência do diagnóstico de amiloidose, uma doença de frequência incomum nos hospitais gerais, através de técnicas simples e acessíveis de coloração histológica. Metodologia: relatamos o caso de um paciente de 57 anos de idade, que foi admitido no departamento de emergência devido a complicações de hipertensão arterial sistêmica com evidências de doença de depósito, submetido à biópsia renal. Resultados: a análise histológica confirmou a presença de depósitos amiloides renais através da coloração cristal de violeta. Conclusões: técnicas histopatológicas simples e acessíveis são métodos viáveis para auxiliar no diagnóstico de amiloidose, uma doença de depósito infrequente em centros não especializados.
Microstructural evolution and ferroelectricity in HfO2 films
Authors: Zhao Dou , Chen Zibin , Liao Xiaozhou
Published: February 2022

Ferroelectric (FE) materials, which typically adopt the perovskite structure with non-centrosymmetry and exhibit spontaneous polarization, are promising for applications in memory, electromechanical and energy storage devices. However, these advanced applications suffer from the intrinsic limitations of perovskite FEs, including poor complementary metal oxide semiconductor (CMOS) compatibility and environmental issues associated with lead. Hafnium oxide (HfO2), with stable bulk centrosymmetric phases, possesses robust ferroelectricity in nanoscale thin films due to the formation of non-centrosymmetric phases. Owing to its high CMOS compatibility and high scalability, HfO2 has attracted significant attention. In the last decade, significant efforts have been made to explore the origin of the ferroelectricity and factors that influence the FE properties in HfO2 films, particularly regarding the role of microstructure, which is vital in clarifying these issues. Although several comprehensive reviews of HfO2 films have been published, there is currently no review focused on the relationship between microstructure and FE properties. This review focuses on the microstructure-property relationships in FE polycrystalline and epitaxial HfO2 films. The crystallographic structures and characterization methods for HfO2 polymorphs are first discussed. For polycrystalline HfO2 films, the microstructure-FE properties relationships, driving force and kinetic pathway of phase transformations under growth parameters or external stimuli are reviewed. For epitaxial films, the lattice matching relations between HfO2 films and substrates and the corresponding impact on the FE properties are discussed. The FE properties between polycrystalline and epitaxial HfO2 films are compared based on their different microstructural characteristics. Finally, a future perspective is given for further investigating FE HfO2 films.
MÜHENDİSLİK ÖĞRENCİLERİNDE COVID-19 PANDEMİSİNİN ERGONOMİK KOŞULLAR ÜZERİNE ETKİSİ
Authors: BERKMEN Sabahattin , ÖZALP Yunus Can
Published: February 2022

Ergonomi, insanların kullanımı için verimli ve güvenli bir şekilde etkileşime girecek ve verimliliği artıracak şekilde şeyleri tasarlamak ve düzenlemek için kullanılan uygulamalı bir bilimdir. Çalışmamız kesitsel türde olup evrenini Mühendislik Mimarlık Fakültesi öğrencilerinden 85 Endüstri Mühendisliği öğrencisi ve 66 Makine Mühendisliği öğrencisi olarak toplam 151 kişinin oluşturduğu ve verilerin online olarak toplanıp analiz edilmiştir. Bu çalışmada ergonominin temel ve bilimsel ilkelerini mühendislik fakültelerinde COVID-19 pandemisinin ergonomik koşullar ve buna bağlı gelişen sonuçlar üzerine olan etkisi incelenmiş olup pandemi öncesi ve sonrası olarak mukayese edilmiştir. Çalışmamızda katılımcıların %50’sinden fazlası endüstri mühendisliği öğrencisi olan, 18-22 yaş aralığında, genel akademik not ortalaması (GANO) 2,1-2,9 olan, masa başında 5 saatten fazla vakit geçiren, sigara kullanmayan, pandemi öncesi D vitamini takviyesi almayan, düzenli egzersiz ve spor alışkanlığı olmayan, herhangi bir bel ağrısı şikayeti olmayan ve ergonomik koşullara kısmen de olsa önem gösteren profildedir. Pandemi sonrasında da yine katılımcıların %50’sinden fazlasında pandemi öncesi gösterilen profil devamlılık gösterip D vitamini takviyesi alımı, bel ağrısı şikayetleri, ergonomik koşullara gösterdikleri özen ve kilo alımları artarken düzenli egzersiz-spor alışkanlıkları ise azalmıştır.
Database “Biography” – a New Information Resource of the State Public Historical Library of Russia
Authors: Shaposhnikov K. A.
Published: February 2022

The article is devoted to a new information resource of the State Public Historical Library of Russia (SHPL) – the Biography database, which takes into account publications of a biographical and iconographic nature in pre-revolutionary periodicals. The database is part of the reference apparatus of the biography cabinet – a new structural unit as part of the reference and bibliographic department of the SHPL. A distinctive feature of the resource is the combination of biographical information about a person, bibliographic descriptions of information sources and direct links to their digital copies in the “Open Electronic Library” of the SHPL. The practical experience of the SHPL bibliographers in the formation of the database and the creation of normative records is presented, the range of sources used in its formation and the creation of normative records is characterized. Examples of normative records of geographic objects are given. The main search capabilities of the database, available to readers of the SHPL and for remote users are described. The possibilities of further development of the information resource, including information from registers of births, creation of a corporate project with interested libraries and archives of the constituent entities of the Russian Federation are considered. This will provide additional opportunities to recreate the biographies of Russians of the late 19th – early 20th centuries, and can become a serious help both for professional historians and for a wide range of amateur genealogists studying the history of their famil.
ВОСПРИИМЧИВОСТЬ И ПАТОГЕННОСТЬ ВЫЗЫВАЮЩИХ ОЗАБОЧЕННОСТЬ ВАРИАНТОВ ВИРУСА SARS-CoV-2 В МЫШИНОЙ МОДЕЛИ
Authors: Шиповалов Андрей , Кудров Глеб , Томилов Алексей , Боднев Сергей , Болдырев Никита , Овчинникова Алена , Зайковская Анна , Таранов Олег , Ивлева Елена , Пьянков Олег , Максютов Ринат
Published: February 2022

Оценена восприимчивость различных линий мышей к генетическим вариантам вируса SARS-CoV-2. При интраназальном заражении мышей инбредных линий (BALB/c, СВА и C57Bl/6z) и аутбредных мышей CD1 вызывающими обеспокоенность вариантами (VOC) вируса SARS-CoV-2 в дозе 2×103 ЦПД50 показано размножение вируса в легких с максимальными значениями концентраций через 72 часа после заражения. Выявлена восприимчивость мышей линии BALB/c к генетическим вариантам вируса SARS-CoV-2, определена 50% инфицирующая доза при интраназальном заражении (ИД50), гистологический анализ показал специфические для COVID 19 поражения тканей легкого инфицированных животных. Наше исследование показывает, что мыши линии BALB/c могут использоваться в качестве модельного животного в скрининговых исследованиях при оценке эффективности терапевтических, вакцинных препаратов и изучении патогенеза, вызванного вариантами VOC вируса SARS-CoV-2: Альфа (B.1.1.7), Бета (B.1.351), Гамма (P.1), Омикрон (B.1.1.529) и им подобными.
Анализ динамики эпидемического процесса COVID-19 в мире за неделю с 19.02.2022 г. по 25.02.2022 г.
Authors: Зимирова Анастасия , Поспелов Михаил , Иванова Александра , Дмитриева Людмила , Чумачкова Елена , Карнаухов Игорь , Щербакова Светлана , Кутырев Владимир
Published: February 2022

В обзоре представлен анализ эпидемиологической ситуации в странах мира по COVID-19, за неделю с 19.02.2022 г. по 25.02.2022 г.
Agentivité et citoyenneté linguistique de la francophonie en Ontario
Authors: Macé Fanny
Published: February 2022

Avec plus de 622 000 francophones (Gouvernement de l’Ontario, 2019), l'Ontario compte la plus importante minorité francophone hors Québec et sa principale minorité linguistique. Cependant, le manque de visibilité publique de la francophonie ontarienne nous a amenés à remettre en question cette quasi-absence. Selon James Scott (2009), les occasions d'entendre publiquement la voix des minorités sont l'exception plutôt que la règle. Au-delà des droits linguistiques, le concept de citoyenneté linguistique (Linguistic Citizenship; Lim et al., 2018) semble prometteur car il nous conduit à nous interroger sur le degré d'agentivité sociale des acteurs minoritaires par rapport à leur voix. Grâce à l'analyse du court-métrage de Claudette Jaïko – « Deux voix, comme en écho » (1987) – cet article démontrera que les micro-actes sociolinguistiques réalisés par des acteurs sociaux minoritaires permettent d'affirmer des degrés divers de citoyenneté linguistique conduisant à l'appropriation d’une voix pour les francophones en Ontario.
Site Selection for Municipal Solid Waste Landfill: Case Study of Artvin, Turkey
Authors: Akinci Halil , Demirarslan Kazim Onur
Published: February 2022

This study aimed to select a landfill site for the disposal of municipal solid waste (MSW) produced in the central district of Artvin Province in the Eastern Black Sea region of Turkey. Although Artvin has a smaller population compared to other provinces in the region, it has become increasingly important as it hosts sensitive ecological areas as well as dams used for energy production. Currently, the MSW collected in the provincial center is disposed through uncontrolled dumping. The topographic structure of the region is rather rough, which makes the selection and application of disposal methods difficult. However, increasing detrimental impact on the environment justifies the immediate necessity for a new landfill site. These considerations necessitate a study for landfill site selection in the region. Many different factors are considered when selecting the site for a landfill, and, thus, the process is not a simple one. In this study, various factors, including geology, slope, land use, distance from settlements, roads, surface waters, faults, and protected sites, as well as the landslide and flood susceptibility of the site, were taken into consideration. These factors were standardized using the fuzzy membership functions and weighted through the analytical hierarchy process. Spatial analysis in the GIS environment revealed that 99.91 percent of the study area was considered unsuitable, 0.08 percent moderately suitable, and only 0.01 percent suitable for landfilling. The study identified two sites that can be used as a landfill.
Insecticide-induced changes of photosynthetic pigments content in peach leaves
Authors: Vuković Slavica
Published: February 2022

In this study, the impact of insecticides on the chlorophyll and carotenoid contents in peach leaves was assessed. Applied insecticides are registered in Republic of Serbia and some EU countries for the control of the oriental fruit moth (Grapholita molesta Busck) in peach orchards. The experiments were set up in peach orchards (variety “Royal gem”) at the localities of Čelarevo and Šišatovac (northern region of the Republic of Serbia). The applied spray liquids from different chemical groups based on cyantraniliprole (a.i. 100 g/l), chlorantraniliprole (a.i. 200 g/l), spinetoram (a.i. 250 g/l), indoxacarb (a.i. 150 g/l), acetamiprid (a.i. 200 g/kg), deltamethrin (a.i. 25 g/l), pyriproxyfen (a.i. 100 g/l) and chlorpyrifos (a.i. 250 g/l), were foliar applied at a concentrations of 0.06, 0.02, 0.02, 0.05, 0.025, 0.05, 0.1 and 0.25%, respectively. Leaves were sampled 3 and 7 days after treatment and analysed for the contents of photosynthetic pigments. Results showed the most adverse impact on the total chlorophyll; their content decreased after application of chlorantraniliprole (32.6-52.7%), indoxacarb (31.1-47.5%), chlorpyrifos (32.4-36.9%), pyriproxyfen (19.5-37.7%) and cyantraniliprole (22.8-33.4%). However, the carotenoid content was increased (16.3 to 117.1%) in the analyzed samples three and seven days after the treatment at both localities, except spinetoram which reduced carotenoids content by 2%. In general, the tested pigments in peach leaves showed a different biochemical reaction depending on the applied insecticides.
Small-Scale Determination of Total Phenols, Tannins, and Flavonoids from Foliar Tissue Using Colorimetric Assays
Authors: Bravo-Monzón Angel E. , Montiel-González Cristina , Avila-Cabadilla Luis Daniel , Alvarez-Añorve Mariana Y.
Published: February 2022

The quantification of plant secondary metabolites at levels higher than the population (i.e. community and ecosystem) requires the implementation of efficient, low-cost, and small-scale assays. We propose a modified protocol based on the Folin-Ciocalteu colorimetric assay that integrates the simultaneous quantitative determination of total phenols and total tannins from 40 µL of methanolic extract, and a modified aluminum chloride assay to quantify total flavonoids from 20 µL of methanolic extract. These miniaturized microplate colorimetric assays were tested and adjusted to work with as little as 50 mg of foliar tissue and to encompass the variation of secondary metabolite concentrations present in trees of 77 species, 58 genera, and 27 families from conserved and secondary tropical dry forest. At present, these new protocols are of great relevance to study ecological processes in highly diverse and strongly threatened ecosystems.
Deep learning-based methods for forecasting Brent Crude Oil return considering COVID-19 pandemic effect
Authors: Khodaee Pouya , Sajadi Seyed Mehrzad Asaadi , Hajizadeh Ehsan , Farhadi Sabri
Published: February 2022

Forecasting return and profit is a primary concern for financial practitioners. It is even more critical when it comes to forecasting energy market returns. This research attempts to propose an effective method for predicting the Brent Crude Oil return, which results in remarkable performance compared to the well-known models in the return prediction. The proposed model is a hybrid model based on LSTM and CNN networks where ARIMA and GARCH outputs are used as features along with return lags, price, and macroeconomic variables for training the models, resulting in significant improvement in the model's performance. According to the obtained results, our proposed model performs better than other models, including ANN, PCA-ANN, LSTM, CNN. In the second part of this study, by considering the spread of the COVID-19 and its impact on the financial markets, we present a precise LSTM model that can reflect this disease's impact on the Brent Crude Oil return. This paper uses the significance test and correlation measures to show similarity between the series of Brent Crude Oil during the SARS period and COVID-19; after that, we use SARS period data along the COVID-19 to train the LSTM. The results demonstrate that the proposed LSTM model, tuned by the SARS data, can better predict the Brent Crude Oil return during the COVID19 pandemic.
Investigating the Effectiveness of Tele-Counselling Psychological Intervention on the Perinatal Mental Health During the Outbreak of COVID-19: A Randomized Trial
Authors: Dadshahi Sahebeh , Ahmadi Atefeh , Ghazanfarpour Masumeh , Alidousti Katayoun , Yousefi Setareh , Pakdel Zahra , Nasrollahi Masoumeh , kashfi Zahra , Esmaeilinejadhasaroeih Fatemeh , Khaleghi Rezvan , Noormohammadi Parinaz
Published: February 2022

Design: This is a randomized trial with a control and an intervention group. The aim of this study was to investigate the effect of psychological interventions on women's mental health in the perinatal period duringsars-cov-2 pandemic. Method: This study was performed on 60 women in the perinatal period (30 in the control group and 30 in the intervention group). The women in the intervention group were included in 6 weekly sessions of 90-120 minutes of tele-counseling. Anxiety, depression, health anxiety and its dimensions were assessed by modified Hospital Anxiety-Depression Scale (HADS) and Short Health Anxiety Index (SHAI) before and after the intervention in both groups. Data were analyzed by SPSS-22 and Kolmogorov-Smirnov, Shapiro-Wilkes tests, one way-ANOVA and paired t-test, Kruskal-Wallis, Wilcoxon paired t-test and K-2. Results: Health anxiety had a significant decrease in both dimensions (anxiety of being sick and negative consequences of disease) (p = 0.007, p = 0.005) while depression and anxiety related to COVID-19 hadn’t been changed significantly (P = 0.34 and p = 0.92). Conclusion: Psychological intervention by tele-counseling approach can be effective as a suitable therapeutic approach to reduce health anxiety in the perinatal period. Trial registration: IRCT20170611034452N12. Trial Id: 50289, 12/20/2020 Keywords: Psychological interventions, tele-counseling, mental health, Corona, perinatal period
Analysis Of The Genotypic Profile And Its Relationship With The Clinical Manifestations In People With Cystic Fibrosis: Study From A Registry Of Rare Diseases.
Authors: Nieto Senay Rueda , Mondejar-Lopez Pedro , Mira-Escolano María-Pilar , Cutillas-Tolín Ana , Maceda-Roldán Luis Alberto , Arense-Gonzalo Julián Jesús , Palomar-Rodríguez Joaquín A.
Published: February 2022

Background: Cystic fibrosis (CF) has a very heterogeneous mutational spectrum in Europe. This variability has also been described in Spain, and there are numerous studies that relate CFTR variants with the symptoms of the disease. Most of them analyze determinate clinical manifestations or specific sequence variants in patients from clinical units. Others use registry data without addressing the genotype-phenotype relationship. Therefore, the objective of this study is to describe the genetic and clinical characteristics of people with CF, and to analyze the relationship between both, using data from the rare diseases registry of a region in southeastern Spain.Methods: A cross-sectional study was carried out in people with a confirmed diagnosis of CF registered in the Rare Diseases Information System (SIER) of the Region of Murcia (Spain). The patients were classified into two genotypes according to the functional consequence that the genetic variants had on the CFTR protein.Results: There were 192 people diagnosed with CF reported in the Region of Murcia until December 31, 2018. Seventy-six different variants were described being the most common c.1521_1523delCTT (p.Phe508del) in 58.3% of people and 37.0% of alleles. Sixty-seven percent of the patients were classified as high-risk genotype, which was associated with a lower percentage of FEV1 [OR: 3.4 (95%CI: 1.1, 10.8)], an increased risk of colonization by Pseudomonas aeruginosa and Achromobacter xylosoxidans [OR: 4.2 (95%CI: 1.3, 13.8) and 7.1 (95%CI: 1.1, 47.2), respectively] and the presence of pancreatic insufficiency [OR: 21.8 (95%CI: 7.9, 59.9)] as compared with those with mild variants.Conclusions: The Region of Murcia has one of the lowest allele frequencies of p.Phe508del described in Europe and high genetic heterogeneity, which could explain the high proportion of patients with mild disease. Furthermore, our results support the association between genotypes compound of two severe variants and the presence of pancreatic insufficiency, increased risk of respiratory infection, and serious lung damage.
Dexmedetomidine Alleviates Inflammatory Response and Oxidative Stress Injury of Vascular Smooth Muscle Cell via α2AR/PI3K/AKT Pathway in Intracranial Aneurysm
Authors: Zhang Ze , Mu Xiue , Zhou Xiaohui
Published: February 2022

Vascular smooth muscle cell (VSMC) phenotypic modulation regulates the initiation and progression of intracranial aneurysm (IA). Dexmedetomidine (DEX) is reported to play neuroprotective roles in patients with craniocerebral injury. Therefore, we investigate the biological functions of DEX and its mechanisms against IA formation and progression. Rat primary VSMCs were isolated from Sprague-Dawley rats. IA and STA tissue samples were obtained from patients with IA. Hydrogen peroxide (H2O2) was used to mimic IA-like conditions in vitro. Cell viability was detected using CCK-8 assays. Wound healing and Transwell assays were performed to detect cell motility. ROS production was determined by flow cytometry. Western blotting and RT-qPCR were carried out to measure gene expression levels. Inflammation responses were determined by measuring inflammatory cytokines. Immunohistochemistry staining was conducted to measure α2-adrenergic receptor levels in tissue samples. DEX alleviates the H2O2-induced cytotoxicity, attenuates the promoting effects of H2O2 on cell malignancy, and protects VSMCs against H2O2-induced oxidative damage and inflammation response. DEX activates the GSK-3β/MKP-1/NRF2 pathway via the α2AR. DEX alleviates the inflammatory responses and oxidative damage of VSMCs by activating the GSK-3β/MKP-1/NRF2 pathway via the α2AR in IA.
The correlation of the serum kynurenine level with P50 in first-episode patients with schizophrenia
Authors: Tan Yunlong , Yang Qingyan , Zhang Yong , Yang Kebing , Niu Yajuan , Fan Fengmei , Chen Song , Luo Xingguang , Tan Shuping , Wang Zhiren , Tong Jinghui , Yang Fude , Li Chiang-Shan R.
Published: February 2022

Background: Increasing facts demonstrated the occurrence of sensory gating defects in schizophrenic sufferers, which had relation to the weakening of P50 response inhibition and had association with α7 nicotinic acetylcholine receptor (α7nAChR). Nevertheless, as a noncompetitive antagonist of α7nAChR, Kynurenic acid (KYNA) cannot cross the blood-brain barrier (BBB). In contrast, Kynurenine (KYN), as a precursor of KYNA metabolism, is capable of crossing the BBB. The exploration focused on investigatating the relation of the serum KYN level with P50 among first-episode patients with schizophrenia (FEPS).Methods: In the exploration, measurement of P50 sensory gating was conducted among 82 FEPS and 73 healthy controls (HC). Positive and Negative Syndrome Scale (PANSS) was used for assessing the psychopathology; and liquid chromatography-tandem mass spectrometry was utilized for measuring the the serum KYN level. Spearman rank correlation coefficient was used to test the correlation between P50 index and serum KYN level and PANSS score. Pearson correlation coefficient was used to test the correlation between serum KYN level and PANSS score.Results: The serum KYN levels[(251.46 ± 65.93) ng/ml vs. (320.65 ± 65.89) ng/ml, t = -6.38, p < 0.001], S1 amplitude [ (2.88(1.79, 3.78) μV vs. 3.08(2.46, 4.56) μV , Z = -2.17, p =0.030] and S1 minus S2 amplitude [1.60(0.63, 2.49) μV vs. 1.92(1.12, 2.93) μV , Z = -2.23, p = 0.026] in FEPS were apparently lower than those in the HC. An obviously inverse correlation was seen between S1 minus S2 amplitude and the serum KYN levels (r = -0.32, p = 0.004) in the FEPS.
Biochemical composition, nutraceutical profile, and GC-MS analysis of novel euryhaline microalgal cultures from Punjab, India.
Authors: Garg Diksha , Gupta Urmila
Published: February 2022

Microalgae have gained recognition in the scientific community as a potential source of nutraceuticals because it is a sustainable reservoir having the capability to substitute the industrial production of ordinary organic chemical based health supplements. The biomass of microalgae incorporates various functional biomolecules like chlorophyll, carotenoids and phenols that exhibit therapeutic properties and serve as nutraceuticals. In spite of the higher production of the microalgal biomass, their biochemical composition differs, and lack of characterization for nutraceutical properties are the prime hindrance in upscaling these bio-factories. Nutraceuticals are nutrient components of the food that not only exhibit many health benefits but also prevent the occurrence of various health disorders. Two euryhaline microalgal strains BGLR8 and BGLR16, isolated from water logged areas of Punjab, India were screened for biomass production and biochemically characterized for the nutraceutical values. Results indicated that BGLR8 produced maximum amount of nutraceutical compounds such as lipid (86 mg/g), chlorophyll (29.42 mg/g), carotenoid (28.82 mg/g), phenols (4.46 mg/g), phycocyanin (52 mg/g), astaxanthin (19.27 mg/g) and β-carotene (5.6 mg/g) and anti-oxidant activity (31.73%). The results of Gas Chromatography-Mass Spectrometry (GC-MS) revealed the presence of 8 therapeutic compounds viz. Dimethyl (E)-but-2-enedioate, Hexasilacyclododecane, Heptasilacyclotetradecane, Methyl (Z)-pentadec-8-enoate, Methyl octadec-13-enoate, Methyl hexadecanoate, Methyl octadecanoate, Methyl-octadeca-9,12-dienoate in BGLR8. Molecular identification through 18S rRNA gene sequencing confirmed BGLR8 to be a member of Coelastrella. (GenBank accession no.- MW443083.1).
Efficient Biodegradation of Di-(2-Ethylhexyl) Phthalate by a Novel Strain Nocardia Asteroides LMB-7 Isolated From Electronic Waste Soil
Authors: Chang Tian-Tian , Lin Zhi-Wei , Zhang Liu-Qing , Liu Wei-Bing , Zhou Ying , Ye Bang-Ce
Published: February 2022

The di-2-ethylhexyl phthalate (DEHP) degrading strain LMB-7 was isolated from electronic waste soil. According to its biophysical/biochemical characteristics and 16S rRNA gene analysis, the strain was identified as Nocardia asteroides. Optimal pH and temperature for DEHP degradation were 8.0 and 30°C, respectively, and DEHP removal reached 97.11% after cultivation for 24 h at an initial concentration of 400 mg/L. As degradation intermediates, di-butyl phthalates, mono-2-ethylhexyl phthalate and 2-ethylhexanol could be identified, and it could be confirmed that DEHP was completely mineralized by strain LMB-7. To our knowledge, this is the first report of DEHP degradation by a strain of Nocardia asteroides, at rates higher than those reported to date. This finding provides a new way for DEHP elimination from environment.
Cellulomonas Triticagri Sp. Nov., A Novel Actinomycete Isolated From The Rhizosphere Soil Of Wheat (Triticum Aestivum L.)
Authors: Han Chuanyu , Zhang Yuting , Yu Bing , Shan Qiqi , Zhao Junwei , Shi Haoran , Tian Yuanyuan , Zhang Yan , Zhu Chunyu , Xiang Wensheng
Published: February 2022

A Gram-positive, motile, rod-shaped and lignin-degraded novel actinomycete, designated strain NEAU-YY56T, was isolated from the rhizosphere soil of wheat (Triticum aestivum L.) collected from Zhumadian, Henan Province, Central China and characterized using a polyphasic approach. Phylogenetic analysis based on the 16S rRNA gene sequence indicated that strain NEAU-YY56T belonged to the genus Cellulomonas and exhibited 16S rRNA gene sequence similarities of 98.7, 98.2 and 98.1 % to Cellulomonas pakistanensis JCM 18755T, Cellulomonas denverensis W6929T and Cellulomonas hominis JCM 12133T, respectively. The morphological characteristics [Gram-positive and short rod-shaped cells] and chemotaxonomic properties [whole-cell sugars: glucose, rhamnose and ribose; major polar lipids: diphosphatidylglycerol, phosphatidylethanolamine, phosphatidylinositol mannoside and two unknown glycolipids; major menaquinones: MK-9(H4) and MK-9(H2); major fatty acids (> 5.0 %): anteiso-C15:0, C16:0, C14:0 and anteiso-C17:0; DNA G+C content: 74.7 %] of strain NEAU-YY56T have also confirmed the affiliation of the isolate to the genus Cellulomonas. However, DNA-DNA relatedness, physiological and biochemical characteristics indicated that strain NEAU-YY56T can be clearly differentiated from its closest relatives. Therefore, it is concluded that strain NEAU-YY56T represents a novel species of the genus Cellulomonas, for which the name Cellulomonas triticagri sp. nov. is proposed. The type strain is NEAU-YY56T (= DSM 106717T = JCM 32550T).
Thyroid Lesions as Diagnosed by Fine-Needle Aspiration Cytology in Uganda: A Five Year Retrospective Study
Authors: Denis Gesa Elly , Lukande Robert , Bukirwa Phiona , Abila Derrick Bary , Boaz Mwesigwa
Published: February 2022

Background
Fine needle aspiration cytology of the thyroid gland has proven to be effective in the categorization of thyroid lesions into benign, atypical, suspicious and malignant categories. However only scanty data has been available regarding the prevalence of thyroid lesions in Uganda. This study aimed at classifying thyroid lesions cytologically and to determine their correlation with the social demographic characteristics.
Methodology:
A laboratory based retrospective study involving a review of 170 cases was conducted at MAKCHS pathology department between 2012 and 2016. FNA results were independently categorized into 4 groups in accordance to Bethesda system for reporting thyroid cytopathology. The data collected was entered using Epidata software and exported to SPSS for analysis.
Results
Out of the 170 cases reviewed, 148 (87.1%) were benign, 3 (1.8%) were suspicious for Follicular Neoplasm, 5 (2.9%) were suspicious of malignancy & 14 (8.2%) were malignant. Colloidal nodule (41.2%) was most prevalent lesion among the benign cases, followed by Follicular adenoma (25.3%). Malignant category was dominated by papillary carcinoma (7.1%). The peak age group for benign lesions was 40–49 years whereas the peak age group for malignant lesions was 40–49 years & 50-59years age group.
Conclusion
The present findings are consistent with those published in other literature with benign lesions showing predominance over the malignant lesions. Sex and age were found to be associated with a specific diagnosis with the females being most affected as well as those in the older groups.
Stakeholder opinions on the structure and development of a new risk of bias tool to assess systematic reviews with network meta-analysis (RoB NMA tool): a cross-sectional survey
Authors: Lunny Carole , Veroniki Areti Angeliki , Hutton Brian , White Ian R , Higgins Julian PT , Wright James M , Kim Ji Yoon , Thirugnanasampanthar Sai Surabi , Siddiqui Shazia , Moja Lorenzo , Taske Nichole , Lorenz Robert , Gerrish Savannah , Straus Sharon , Minogue Virginia , Hu Franklin , Kapani Ayah , Nagi Samin , Chen Lillian , Akbar-nejad Mona , Tricco Andrea C.
Published: February 2022

Introduction: Network meta-analysis (NMA) is increasingly used in guideline development and other aspects of evidence-based decision-making. We engaged with stakeholders in early phases of the development of a new tool to assess risk of bias (RoB) in NMA to facilitate its later use and potentially widen its impact. Methods: We surveyed stakeholders’ views and preferences about the importance, utility, and willingness to use the RoB NMA tool to evaluate evidence in practice and in policymaking. We included 12 closed and 10 open-ended questions, and followed a knowledge translation plan to disseminate the survey through social media and professional networks. Results: A total of 298 stakeholders participated in the survey (14% respondent rate) which took on average 2 minutes to complete. 75% of stakeholders indicated that their organization produced NMAs, and 78% of respondents showed high interest in the tool. Most stakeholders (84%) reported they would use the tool to assess an NMA if they had received adequate training, while half reported they preferred a tool to assess both bias in individual NMA results and authors’ conclusions. Twelve (8%) stakeholders said they would use the tool to conduct an overview of reviews, while 24 (17%) respondents indicated that they would use the tool to distinguish between NMAs at high and low risk of bias. Conclusions: This survey informs the development of a RoB tool for NMAs and is a pillar in an integrated knowledge translation approach. Stakeholders preferred a tool to assess both bias in individual NMA results and authors’ conclusions.
Ultra-radical surgery for advanced ovarian cancer- a retrospective cohort study in a tertiary referral cancer center in the UK
Authors: Palaiologos Konstantinos , Nikoloudaki Zoe , Adedipe Tolu , Booth Susanne , Flynn Marina , Lykoudis Pavlos , Giannopoulos Theodoros
Published: February 2022

Background
Ovarian cancer is the leading cause of death from gynaecological cancer in the UK. The standard of care is a combination of surgery and chemotherapy. The aim of the treatment is the resection of all macroscopic disease. In selected cases of advanced ovarian cancer this is achieved with ultra-radical surgery. However, NICE encourages further research due to low quality evidence on the safety and efficacy of this extensive surgery.
Objective
The aim of this study is to examine the morbidity and survival rates of ultra-radical surgery for advanced ovarian cancer performed in our unit and compare our findings with the current literature.
Methods
This is a retrospective study of 39 patients diagnosed with stage IIIA-IV ovarian and primary peritoneal cancer who underwent surgery in our unit between 2012 and 2020. The main outcome measures were the perioperative complications, the disease-free survival, the overall survival rate and the recurrence rate.
Results
The study enrolled 39 patients with stages IIIA-IV who were treated in our unit between 2012 and 2020. 21 patients were at stage III (53.8%) whereas 18 (46.1%) at stage IV. 14 patients underwent primary and 25 secondary debulking surgery. Major and minor complications occurred 17.9% and 56.4% of the patients, respectively. Complete cytoreduction following surgery was achieved in 24 cases (61.5%). The mean and the median survival time were 4.8 years and 5 years, respectively. The mean disease free survival time was 2.9 years while median disease free survival time was 2 years. Age (p=0.028) and complete cytoreduction (p=0.048) were found to be significantly associated with survival. Primary debulking surgery was significantly associated with lower probability of recurrence (p=0.049).
Conclusion
Although the number of patients is relatively small, our study indicates that ultra-radical surgery in centres with high expertise may result in excellent survival rates with an acceptable rate of major complications. All patients in our cohort were operated by an accredited Gynaecological Oncologist and a Hepatobiliary General Surgeon with a special interest in ovarian cancer. A few cases required input from a Colorectal and a Thoracic Surgeon. We believe that the careful selection of the patients that can benefit from ultra-radical surgery and our model of joint surgery can explain our excellent results. Further research is essential to establish that ultra- radical surgery has an acceptable rate of morbidity for patients with advanced ovarian cancer.
Case detection and management of mobile leprosy in Baoan District, Shenzhen : A retrospective analysis
Authors: Ye Yun-feng , Huang Zhi-ming , Huang Yan-hui , Li Li-mei , Li Jing , Huang Jun-xin , Liu Hu-yin
Published: February 2022

The mobile leprosy control programme in Baoan district was launched in the late 1990s with the goal of elimination of leprosy in mobile population. Here, we aims to describe the characteristics of mobile people suffering from leprosy and the achievements, over the past 30 years in Baoan District, Shenzhen, China, and identified the challenges for better mobile leprosy control. Data from the Leprosy Management Information System in China (LEPMIS) and the annual Leprosy Records were obtained, including patient’s basic demographic information and clinical characteristics. A total of ninety five patients were newly detected from 1991 to 2020, with the new case detection rate per 100,000 ranging from 0.14 to 0.07, while the prevalence rate per 100,000 ranging from 0.48 to 0.37. There were no childhood cases and relapse cases. 83.2% of mobile patients coming from southwestern and mid-southern provinces were detected. The median length of time between symptom onset and diagnosis was 31 months (range, 3-296 months). 61.1% of patients had nerve damage at the time of diagnosis. Ulnar nerve was the most commonly involved nerve in nearly 50.0% of total patients in the study. Nearly one third of patients had a reaction and neuritis at some point. 16.8% had a disability of Grade 2 and 25.3% of Grade 1. Among these deformities, leprosy deformities involving hand were 22(23.2%), feet were 30(31.6%), eye were 4(4.2%), respectively. A total of 76 patients have completed MDT treatment and none of them relapsed. 4 patients were loss to follow-up and 15 patients moved back to their household registered location. The case finding and management of mobile leprosy has made remarkable progress in this area. The challenges for mobile leprosy elimination in the next stage are multi-sectoral coordination, involvement of the whole society, sustainable support and investment form the government, stable professional workforce, regular follow-up and tracking survey, establishing an effective surveillance network and referral system.
Can Systematic Implementation Support Improve Program Fidelity by Improving Care Providers’ Perceptions of Implementation Factors? A Cluster Randomized Trial
Authors: Hartveit Miriam , Hovlid Einar , Øvretveit John , Assmus Jørg , Bond Gary , Joa Inge , Heiervang Kristin , Stensrud Bjørn , Høifødt Tordis Sørensen , Ruud Torleif
Published: February 2022

Background: Investigations of implementation factors are recommended to better understand and address inadequate implementation outcomes. Little is known about the relationship between implementation factors and outcome, especially in later phases of an implementation effort. The aims of this study were to assess the association between implementation success (measured by program fidelity) and care providers’ perceptions of implementation factors during an implementation process and to investigate whether these perceptions can be affected by systematic implementation support.Methods: Using a cluster-randomized design, mental health clinics were drawn to receive implementation support for one (intervention) and not for another (control) of four evidence-based practices. Program fidelity and care providers’ perceptions (Implementation Process Assessment Tool questionnaire) were scored for both intervention and control groups every sixth month for 18 months. Assessments and group differences were tested by means of descriptive statistics (mean, standard deviation and confidence interval) and linear mixed effect analysis.Results: Including 33 mental health centres or wards, we found care providers’ perceptions of a set of implementation factors to be associated with fidelity but not at baseline. After 18 months of implementation effort, fidelity and care providers’ perceptions were strongly correlated (B(95% CI)= .7 (.2, 1.1), p= .004). Care providers perceived implementation factors more positively when implementation support was provided than when it was not (t(140)=2.22, p=.028). Conclusions: Implementation support can facilitate positive perceptions among care providers, which is associated with higher program fidelity. To improve implementation success, we should pay more attention to how care providers constantly perceive implementation factors during all phases of the implementation effort. Further research is needed to investigate the validity of our findings in other settings and to improve our understanding of ongoing decision-making among care providers, i.e., the mechanisms of sustaining high fidelity of recommended practices. Trial registration: ClinicalTrials.gov Identifier: NCT03271242 (registration date: 05.09.2017).
WITHDRAWN: Germanium-Doped Coupled Ring-Core Fiber for Extremely Dispersive Orbital Angular Momentum Modes
Authors: Geng Wenpu , Fang Yuxi , Wang Yingning , Bao Changjing , Zhang Hao , Huang Hao , Ren Yongxiong , Pan Zhongqi , Yue Yang
Published: February 2022

A coupled ring-core fiber with extremely negative dispersion is proposed, simulated, and analyzed. Featured by two coaxial Ge-doped silica rings, this fiber can support highly dispersive orbital angular momentum (OAM) modes. The dependence of dispersion characteristics on the variable parameters of the fiber is theoretically and systematically investigated, including the geometry parameters and the mole fraction of GeO2. The order of the supported OAM modes in this fiber can be up to 100, achieving a highly negative dispersion reaching to -44,579 ps/(nm·km) at 1348.4 nm. The operation wavelength and the value of dispersion can be adjusted according to the need by selecting the fiber parameters. Furthermore, by adjusting the GeO2 concentration, the operation window of the OAM65,1 mode can be tuned in a much wider range from 1212.4 nm to 1666.2 nm.
Kawasaki Disease Concurrent with Visual Conversion Disorder in Child: A Case Report and Review of The Literature
Authors: Liu Junmei , Zhang Yingying , Zeng Huiqin , zhang jianjiang
Published: February 2022

Kawasaki disease (KD) is a self-limited vasculitis of medium- and small-sized vessels that occurs mainly in children between 5 months and 6 years of age. Conversion disorder is a type of somatoform disorder which is rare occurred in children under six years old. KD accompanied with conversion disorder has never been reported in the literature. We report a 4-year, 6-month-old female KD patient presenting with visual conversion disorder. She presented with classic KD symptoms, including high fever, rash, strawberry tongue and conjunctival and pharyngeal congestion. In addition, the patient displayed transient right vision loss during KD, while her ophthalmology and laboratory tests showed that there were no abnormalities that would result in vision loss; thus, psychogenic factors (conversion disorder) were considered after a simple test to confirm the functional vision loss of the right eye. The case could provides a differential diagnosis for clinical Kawasaki disease combined with vision disorder.
Construction of a prognostic nomogram for transarterial chemoembolization combined with 125I seed implantation for hepatocellular carcinoma with portal vein tumor thrombus: a multicenter retrospective study
Authors: Zhao Xiao-Hui , Zhao Lei , Zhao Yan , Li Hai-Liang , Li Zhen , Cao Guang-Shao , Li Hong-Le , Xu Shi-Jun , Hu Hong-Tao
Published: February 2022

Background: To investigate the efficacy of transhepatic arterial chemoembolization (TACE) combined with 125I seed implantation in patients with first-branch portal vein tumor thrombus (PVTT) hepatocellular carcinoma (HCC), establish a prognostic nomogram to determine the prognosis for individual patients.Methods: We retrospectively collected 102 cases of TACE combined with 125I seed implantation in our hospital as the primary cohort. The main observation index of the results of the study was the median overall survival (mOS). Univariate analysis and LASSO regression with cross-validation were used to screen the variables. The selected variables were included in the multivariate Cox survival regression model, and a prognostic nomogram was developed. The performance of the nomogram was assessed with respect to calibration, discrimination, and clinical usefulness. The internal and external verifications were evaluated.Results: The mOS of all patients was 13.5 months. The final determination was made using the Child-Pugh score, tumor burden, and PVTT types to establish a nomogram prediction model [C -index :0.740 (95% CI: 0.692-0.788), C-index: 0.732 through internal validation]. The model demonstrated good discrimination and calibration. Application of the nomogram to the external verification data still yielded good discrimination [C-index: 0.731(95% CI: 0.656–0.806)], and good calibration. The decision curve analysis demonstrated that the clinical validity of the model is clinically useful.Conclusion: TACE combined with 125I seed implantation indicated better long-term outcomes in patients with HCC combined with type II PVTT. This nomogram can be used to predict the prognostic survival time of such patients and help doctors make decisions in clinical practice.