bluuebunny/crossref_metadata_2025 huggingface dataset:
Penguatan Interpretasi Berbasis Komunitas di Rammang-Rammang, Desa Salenrang Kecamatan Bontoa Kabupaten Maros
Authors:   Politeknik Pariwisata Makassar, Indonesia, Eppang Buntu Marannu , Renold Renold ,   Politeknik Pariwisata Makassar, Indonesia, Rahayu Mia ,   Politeknik Pariwisata Makassar, Indonesia
Published: November 2023

Artikel ini membahas pentingnya kegiatan interpretasi dalam pengembangan daya tarik wisata dan bagaimana pelatihan inter-pretasi dapat memberikan manfaat yang signifikan bagi masyarakat lokal. Interpretasi dalam konteks pariwisata mengacu pada proses menyampaikan informasi, nilai, dan makna suatu destinasi kepada pengunjung untuk meningkatkan pemahaman, apre-siasi, dan kesadaran. Tujuan utama interpretasi adalah memberikan pengalaman berharga kepada pengunjung dan meningkatkan pemahaman mereka tentang sejarah, budaya, dan lingkungan suatu tempat. Interpretasi berbasis komunitas di Rammang-Rammang adalah pendekatan yang melibatkan komunitas lokal sebagai pelaku utama dalam penyampaian informasi kepada pengunjung serta menciptakan kegiatan interpretasi yang dapat memberikan nilai tambah secara finansial bagi mereka yang bukan hanya sekedar memberikan jasa pengantaran dengan perahu ke atraksi utama dan membiarkan pemandu wisata dari luar yang lebih berperan. Secara khusus kegiatan pelatihan ini adalah wujud nyata pengabdian kepada masyarakat oleh Program Studi Perjalanan Wisata Politeknik Pariwisata Makassar. Penguatan kompetensi interpretasi bagi masyarakat merupakan investasi pent-ing yang dapat meningkatkan pengalaman wisatawan, mendukung pendidikan dan kesadaran, serta mendukung pembangunan ekonomi dan keberlanjutan dalam jangka panjang. Untuk melakasanakan kegiatan pengabdian kepada masyarakat telah dil-akukan langkah-langkah yaitu analisis kebutuhan, perencanaan, persiapan, pelaksanaan, dan evaluasi. Materi pelatihan meliputi pengembangan produk interpretasi, teknik storytelling, dan praktik interpretasi di lapangan. Hasil evaluasi menunjukkan bahwa kegiatan pelatihan interpretasi sangat memuaskan dan memberikan manfaat yang signifikan bagi masyarakat. Dengan pelatihan interpretasi yang baik, masyarakat dapat memberikan pengalaman wisatawan yang lebih berharga, meningkatkan pemahaman budaya dan lingkungan, serta mendukung pariwisata berkelanjutan dan pengembangan ekonomi lokal.
Analisis Pengetahuan Pemeliharaan Kesehatan Gigi dan Mulut pada Remaja di Kelurahan Mahawu, Kota Manado
Authors:   Poltekkes Kemenkes Manado, Koch Novarita Mariana , Tahulending Anneke ,   Poltekkes Kemenkes Manado, Musa Sri Delbi Santika ,   Poltekkes Kemenkes Manado
Published: November 2023

Pengetahuan tentang kesehatan gigi dan mulut merupakan modal bagi setiap orang untuk melakukan tindakan kesehatan gigi dan mulut yang lebih baik. Setiap orang, termasuk remaja, merupakan salah satu kelompok remaja yang perlu ditanamkan pengetahuan positif tentang kesehatan gigi dan mulut untuk menciptakan generasi yang benar-benar menyadari betapa pentingnya kesehatan gigi dan mulut, terutama bagi diri mereka sendiri. Tujuan dari penelitian ini adalah untuk mengetahui tingkat pengetahuan menjaga kesehatan gigi dan mulut pada remaja Masjid Darul Jannah. Penelitian ini dilakukan dengan studi deskriptif untuk mendeskripsikan pengetahuan remaja tentang menjaga kesehatan gigi dan mulut di Masjid Darul Jannah Kelurahan Mahawu Kecamatan Tuminting Kota Manado. Cara mengukur pengetahuan adalah dengan menggunakan kuesioner. Statistik pengetahuan yang dihasilkan menunjukkan 20 responden (66,7%) berada pada kategori pengetahuan baik, dan 10 responden (33,3%) memiliki tingkat pengetahuan kurang. Kesimpulannya, tingkat pengetahuan remaja masjid Darul Janah didominasi oleh kategori baik sebanyak 66,7%, dibandingkan remaja yang memiliki tingkat pengetahuan kurang baik sebanyak 33,3%.
SAFEGUARDING INNOCENCE: DEVELOPING CURRICULUM OF ISLAMIC SEXUAL EDUCATION IN EARLY CHILDHOOD
Authors: Pratiwi Hardiyanti , Ismail Murniyanti
Published: November 2023

Article 15 of Law No. 35/2014 affirms the right of every child to be protected from various forms of exploitation, including sexual crimes. A well-structured and age-appropriate Islamic sexuality education curriculum plays an important role in shaping a healthy understanding of children's physical, emotional, and social interactions. This research reviews the development of a sexuality education curriculum using the Dick and Carey development model in an Early Childhood Education (ECE) or Kindergarten B unit that refers to the Merdeka Curriculum. This curriculum includes four learning domains, namely intellectual skills, verbal information, psychomotor skills, and attitudes, which are in line with the Learning Outcomes of religious values and character, identity, and the basics of literacy and Steam. The learning design process begins with goal identification through performance analysis and needs assessment, then designing learning objectives that address specific challenges. The curriculum contains two themes, namely Showing Appropriate Reactions to Verbal Harassment and Inappropriate Touching which has 13 learning outcomes and Maintaining Cleanliness and Hygiene of Sensitive Body Parts which has 5 learning outcomes. The media needed to support learning include videos, picture storybooks, cards, snakes and ladders games, puppets, and songs. The appropriate methods are storytelling, socio-drama, interactive games, and discussions. The product was validated by material and curriculum experts. After revision, the values achieved showed improvement,

with the Curriculum and Learning Evaluation Expert Assessment increasing from 3.06 to 3.74, reflecting increased suitability and effectiveness. The Early Childhood Sexuality Education Material Content Expert Assessment progressed from 3.08 to 3.67, highlighting improved inclusivity and accuracy.
necrotizing fasciitis aprospective study of 18 cases at al yarmouk teaching hospital
Authors: Al kizwini Ghassan A. , Al badri Jasim A.
Published: November 2023

Background: Necrotizing fascitis is a progressive, rapidly spreading inflammatory infection located in the deep fascia, with secondary neerosis of the subcutaneous tissues polymicrobial infection is the most common finding in necrotizing fascitis rather than a single caustive organism.
Combining low-volatility and mean-reversion anomalies: Better together?
Authors: Pätäri Eero , Ahmed Sheraz , Lankinen Tuomas , Yeomans Julian Scott
Published: November 2023

This paper contributes to the existing stock market anomaly literature by being the first to analyze the benefits of combining two distinct anomalies; specifically, the low-volatility and mean-reversion anomalies. Our results show that on a long-only basis, these two time-varying anomalies could be combined into a double-sort investment strategy that includes some desirable characteristics from each of them, thereby making the portfolio return accumulation more stable over time. As the added-value of low-volatility investing stems mostly from the risk-reduction side, while contrarian stocks are generally highly volatile with remarkable upside potential, the use of the double-sort portfolio-formation in which the contrarian stocks are picked from the sub-set of below-median volatility stocks can shorten the below-market performance periods that have occasionally materialized for plain low-volatility or plain contrarian investors.
Long Range (LoRa) and Alert Network System for Forest Fire Prediction
Authors: Kavitha S. , Kanchana K. , Venkatesan G.
Published: November 2023

Forest fires are a regular occurrence throughout the year with an increasing intensity in the summer and fall periods. Forest fires pose a significant threat to ecosystems, property and human lives. Early detection and rapid response are critical to mitigate the devastating effects of these fires. This article presents a Long Range (LoRa) Alert Network System designed for the early prediction and timely notification of forest fires. The system leverages LoRa technology to create a robust and cost-effective wireless communication network in remote forested areas. These fires primarily stem from various natural and environmental phenomena and natural disasters. The timely dissemination of forest fire alerts was hampered, resulting in delays in fire management. In order to address this issue, efforts were made to enhance the capability for prompt forest fire detection. The challenges predominantly revolve around forested regions where data communication infrastructure is deficient. In the event of a forest fire, there exists a network barrier that impedes information transmission. Consequently, forest fire detection systems leveraging Mesh LoRa networks and image processing networks have been devised. An integrated module within the LoRa/GPS HAT has been explored as a potential solution to the fire predicament. The Flame Sensor Module, functioning as a fire detection sensor component, and the LoRa/GPS HAT, serving as a hardware medium for radio frequency data transmission communication, have been employed. The interconnection of these devices within a network facilitates the development of a prototype fire detection system. Combining a Flame Sensor Module with a LoRa/GPS HAT is indeed a viable approach to creating a prototype fire detection and alert system. By combining the Flame Sensor Module with the LoRa/GPS HAT, a scalable and cost-effective fire detection and alert system appropriate for distant and wooded locations with limited traditional communication infrastructure is created. This system can play a crucial role in early fire detection, potentially reducing the severity of forest fires and protecting both natural resources and human lives.
Towards a German labor market ontology: Challenges and applications
Authors: Dörpinghaus Jens , Binnewitt Johanna , Winnige Stefan , Hein Kristine , Krüger Kai
Published: November 2023

The labor market is an area with diverse data structures and multiple applications, such as matching job seekers with the right training or job. For this reason, the multilingual classification of European Skills, Competences, Qualifications and Occupations (ESCO) is a good example of the central role of ontologies in this area. However, ESCO cannot provide all the details of local labor market needs and does not provide links to other hierarchies of competences. For example, other taxonomies of occupations and skills are widely used in German-speaking countries, but they are not in a state where they are easily accessible for interoperability and reasoning. In this paper, we present a first version of a German Labor Market Ontology (GLMO) that uses ESCO as a top-level ontology for the target domain. This makes it highly interoperable and comparable to existing ontologies by providing details for the regional structures in German-speaking countries. In addition, we present a detailed evaluation of the provided data and applications, as well as an extensive discussion of future work.
Effectiveness of ELMo embeddings, and semantic models in predicting review helpfulness
Authors: Malik Muhammad Shahid Iqbal , Nawaz Aftab , Jamjoom Mona Mamdouh , Ignatov Dmitry I.
Published: November 2023

Online product reviews (OPR) are a commonly used medium for consumers to communicate their experiences with products during online shopping. Previous studies have investigated the helpfulness of OPRs using frequency-based, linguistic, meta-data, readability, and reviewer attributes. In this study, we explored the impact of robust contextual word embeddings, topic, and language models in predicting the helpfulness of OPRs. In addition, the wrapper-based feature selection technique is employed to select effective subsets from each type of features. Five feature generation techniques including word2vec, FastText, Global Vectors for Word Representation (GloVe), Latent Dirichlet Allocation (LDA), and Embeddings from Language Models (ELMo), were employed. The proposed framework is evaluated on two Amazon datasets (Video games and Health & personal care). The results showed that the ELMo model outperformed the six standard baselines, including the fine-tuned Bidirectional Encoder Representations from Transformers (BERT) model. In addition, ELMo achieved Mean Square Error (MSE) of 0.0887 and 0.0786 respectively on two datasets and MSE of 0.0791 and 0.0708 with the wrapper method. This results in the reduction of 1.43% and 1.63% in MSE as compared to the fine-tuned BERT model on respective datasets. However, the LDA model has a comparable performance with the fine-tuned BERT model but outperforms the other five baselines. The proposed framework demonstrated good generalization abilities by uncovering important factors of product reviews and can be evaluated on other voting platforms.
Single-structured zero-bias hybrid gas-magnetic bearing and its rotordynamic performance
Authors: Liu Qing , Ge Ruihuan , Wang Li , Ren Tianming , Feng Ming
Published: November 2023

A single-structured hybrid gas-magnetic bearing (HGMB) has been proposed for frequent start/stop occasions, which eliminates foil structures or static pressure systems by using the closed magnetic poles of the active magnetic bearing (AMB) as the bushing of the gas bearing. This allows the proposed bearing to realize the functions of both AMB and gas bearing with a single bearing structure. In this paper, the bias currents of AMB, aimed for enhanced load capacity and dynamic characteristics, are omitted to reduce power consumption and heat. The combination of zero-bias AMB and rigid self-acting gas bearing in a single bearing structure is therefore proposed. The rotor orbits of gas bearing, AMB, single-structured HGMB, and single-structured zero-bias HGMB in conditions of varied horizontal and vertical external loads are simulated. The dynamic performances during the run-up processes of AMB, HGMB, and zero-bias HGMB are investigated. The electromagnetic forces of each kind of bearing are compared. Numerical results demonstrate that by applying the single-structured zero-bias HGMB, the power consumption can be significantly reduced in contrast with pure AMB and single-structured HGMB. The reduced load capacity and dynamic characteristics of zero-bias AMB can be compensated by the rigid self-acting gas bearing, making the single-structured zero-bias HGMB an ideal candidate for cryogenic, ultra-high speed as well as frequent start/stop occasions.
Deep learning based sarcasm detection and classification model
Authors: Bhukya Raghuram , Vodithala Swathy
Published: November 2023

Social media is becoming a crucial part of our everyday lives, whether it’s for product advertising, developing brand value, or reaching out to users. At the same time, sentiment analysis (SA) is a method for determining the emotions associated with online information. The main obstacle to SA’s success is the presence of sarcasm in the text. Previous studies on the identification of sarcasm use lexical and pragmatic signs such as interjection, punctuation, and sentimental change, amongst others. Deep learning (DL) models can be used to learn the lexical and contextual aspects of informal language because handcrafted features cannot be generalised. In addition, word embedding can be used to train the DL models and provide effective results on big datasets at the same time. Optimal Deep Learning based Sarcasm detection and classification using an ODL-SDC method is presented in this study. ODL-SDC analyses social media data to look for and classify any sarcasm that may have been used there. In addition, the Glove embedding approach is used to transform feature vectors. A approach known as the chaotic crow search optimization on deep belief network (CCSO-DBN) is also used to classify and detect satire. Many benchmark datasets were used to evaluate the ODL-SDC method, and the results show it to be more effective than existing approaches in a number of performance metrics.
Optimized distance measures on hesitant fuzzy numbers: An application
Authors: Keikha Abazar , Sabeghi Narjes
Published: November 2023

As the rapidly progressing applications of uncertainty theories, the need for modifications to some of their existing mathematical tools or creating new tools to deal correctly with them in various environments is also exposed. Hesitant fuzzy numbers (HFNs), as a particular case of fuzzy numbers, are not an exception to this rule. Considering the necessity of determining the distance between given HFNs in many of their practical applications, this article shows that the existing methods either do not provide correct results or are not able to meet the needs of users. This paper aims to present new methods for distance measures of hesitant fuzzy numbers. To do them, three prevalent distance measures, i.e., the generalized distance measure, the Hamming distance measure, and the Euclidean distance measure, will be optimized into three distinct trinal categories. With the approach of reducing error propagation via reducing some unnecessary mathematical computations, new distance measures on HFNs will be introduced, first. The middle is the modification of the first category, which is more suitable when the given HFNs are equal-distance by the previous formula. Also, as the third category, the weighted form of these distance measures has been proposed, to be used where the real and membership parts of HFNs are not of equal importance. As an application of these, a TOPSIS-based technique for solving multi-attribute group decision-making problems with HFNs has been proposed. A numerical example will be implemented to describe the presented method. Finally, along with the validation of the proposed method, its numerical comparison with some other existing methods will be discussed in detail.
Using the independent monitoring for quality (IM4Q) program to examine employment in integrated settings in the community for people with IDD over time
Authors: Houseworth James , Feinstein Celia , Pettingell Sandra L. , Bershadsky Julie , Tichá Renáta , Lemanowicz James , Zhang Alicia
Published: November 2023

BACKGROUND: Community-based employment is a key step for many adults with intellectual and developmental disabilities (IDD), a group prone to high unemployment, poverty, and dependency. It is also important in order to avoid poverty and progress toward economically stable and independent lifestyles. Increases in community-based employment for individuals with IDD meet the expectations of the HCBS final rule as well as state-wide transition planning requirements and other compliance indicators. OBJECTIVE: The current study explores changes in employment over time before and after the final rule was issued and other initiatives (e.g., Employment First policy) were adopted. This method provides an important way to detect if the effort is impacting service users with IDD as intended. By comparing three waves of data from the state of Pennsylvania (2013, 2016, and 2019), we can gain insight into changes in employment rates over time among HCBS service users with IDD in light of policy initiatives. METHODS: We used three waves of IM4Q data to compare the growth in employment among 9,486 individual service users with IDD in the state of Pennsylvania. Repeated measures regression using generalized estimating equations (GEEs) was used to examine employment in an integrated setting in the community over time after controlling for age, support needs, residence type, and community type. RESULTS: Controlling for the effects of demographic and environmental characteristics, there was a significant increase in community-based employment among IDD service users in Pennsylvania between 2013 and 2019. Other variables were also associated with employment. CONCLUSION: This study was the first to our knowledge to consider changes in community-based employment across three waves of data for individuals with IDD. The data wave collection periods in Pennsylvania coincided with significant policy changes relevant to service users with IDD. These changes in policy may be effective and warrant both continued exploration of its effects and ways to maximize policy to further integrate adults with IDD into the community.
Improvement of tool calibration in cold pilligrim rolling mill
Authors: Golovacheva M. V. , Orlov G. A. , Vedernikov M. A.
Published: November 2023

In the manufacture of cold rolled tubes, the process performance of the rolling mill and the deformed metal is determined by tool calibration. The method of calibration calculation, the method and equipment of its reproduction significantly affect the deformability and quality of pipes, the cost of rolling tools, productivity, and in general the efficiency of cold (warm) rolling of pipes. Tool calibration is the distribution of individual compressions along the length of the working stroke of the rolls, determined by the shape and size of the grooves and the mandrel. The need to improve the calibration of rolling tools is determined by the ever-increasing requirements for pipe production products. In this article, it is proposed to set the function of relative reductions as a product of elementary functions. In the course of the work, the coefficients of the proposed function were determined from the condition of the minimum load on the gauge at the pre-calibration section to ensure the minimum longitudinal difference in the thickness of the pipes. Calibration and forces during rolling of stainless thin-walled pipes of size 95×2 mm by the improved method have been calculated using MS Excel. The force parameters of rolling, calculated using the improved method, are compared with the forces calculated using other well-known calibration calculation methods. It is shown that the proposed technique provides lower values of force on most of the crimping section, which allows reducing longitudinal variation of pipes and increasing durability of calibers. To assess the accuracy of rolled pipes, the calculation of the elastic deformation of the stand was carried out depending on the force in the pre-calibrating section. The calculated value shows that the proposed improved method of tool calibration allows rolling pipes of increased accuracy. The developed procedure involves the use of size 95×2 mm pipes made of 12X18H10T steel for rolling in order to produce from a two-pass scheme to a single-pass scheme while ensuring the required high cost of pipes.
Influence of technological heating used in the manufacture of parts on the initial structure of 10G2FBYu steel after controlled rolling
Authors: Kareva N. T.
Published: November 2023

Modern pipe steels for the main pipelines belong are of the high-strength class of X70 and higher. The steels must simultaneously still have sufficient viscosity at low operating temperatures, hardenability and good weldability. This set of properties is achieved by combining the optimal material composition and the method of manufacturing a sheet billet using controlled rolling. Subsequent operations for the manufacture of pipes, connecting parts of oil and gas pipelines (welding, heat treatment, etc.), accompanied by inevitable high-temperature heating, can significantly affect the initial structure of the sheet and the level of its properties. In this case, the possible growth of austenite and ferrite grains, as well as the loss of hot work hardening, should negative effect the mechanical properties of pipe steel. However, taking into account the peculiarities of the chemical composition and structure of sheet pipe steels subjected to controlled rolling, containing hardly soluble fine particles of carbides and carbonitrides based on vanadium, niobium, titanium, which inhibit recrystallization, one can expect the preservation of a fine-grained structure and a part of hot work hardening with a rational scheme for manufacturing parts. The article presents data on the study of the structure and hardness of low-carbon low-alloy steel 10G2FBYu of strength class K60 after repeated normalization from temperatures of 850, 880, 910 and 940°C. Structural studies performed using metallographic and electron microscopes Carl Zeiss Axio Observer and JEOL JSM-7001F showed that after additional heating at the indicated temperatures, the grain sizes increase, but not significantly. The hardness of steel is reduced by 20% or less, depending on the normalization mode
Post-stroke pain and rehabilitation (case report)
Authors:   Yaroslavl State Medical University, Yaroslavl, Russian Federation, Pizova N.V. , Pizov N.A. ,   Clinical Hospital No. 2, Yaroslavl, Russian Federation, Mareev M.S. ,   Yaroslavl State Medical University, Yaroslavl, Russian Federation
Published: November 2023

Pain is one of the most common symptoms that occur in neurological practice. Pain after a stroke is a common clinical problem insufficiently diagnosed and treated, which is due to differences in methods aimed at solving the problem. For instance, there are different definitions of the pain type, study designs, examined patient cohorts and, commonly, neglects by doctors of an active patient survey on this complaint. This article describes the most common pain syndromes, including central post-stroke pain, shoulder pain after stroke, complex regional pain syndrome and pain associated with spasticity. The incidence of various post-stroke pain types, their clinical manifestations and risk factors for occurrence are presented. The article also shows main directions of pharmacological and non-pharmacological treatment, medical rehabilitation of patients with post-stroke pain syndromes. Medical rehabilitation of patients with post-stroke pain syndromes includes functional status assessment, goal setting in rehabilitation, selection of measures and regular assessment of ongoing rehabilitation activities with the patient and relatives participation. The article presents a case study that reflects the following problem — hemiplegic shoulder pain after stroke which is commonly found in practice, persists for a long-term period and requires diagnosis at each hospitalization in the department of rehabilitation with the selection of individual treatment depending on the specific clinical case. KEYWORDS: post-stroke pain syndromes, ischemic stroke, risk factors, medical rehabilitation. FOR CITATION: Pizova N.V., Pizov N.A., Mareev M.S. Post-stroke pain and rehabilitation (case report). Russian Medical Inquiry. 2023;7(10):672–679 (in Russ.). DOI: 10.32364/2587-6821-2023-7-10-10.
Chronic pain in elderly and senile patients: clinical recommendations and difficulties in real practice
Authors:   Pirogov Russian National Research Medical University, Moscow, Russian Federation, Naumov A.V. ,   Russian Gerontological Research and Clinical Center of the Pirogov Russian National Research Medical University, Moscow, Russian Federation, Khovasova N.O. ,   Pirogov Russian National Research Medical University, Moscow, Russian Federation,   Russian Gerontological Research and Clinical Center of the Pirogov Russian National Research Medical University, Moscow, Russian Federation, Polyanskaya A.R. ,   Russian Gerontological Research and Clinical Center of the Pirogov Russian National Research Medical University, Moscow, Russian Federation, Tokareva L.G. ,   Russian Gerontological Research and Clinical Center of the Pirogov Russian National Research Medical University, Moscow, Russian Federation, Tkacheva O.N. ,   Pirogov Russian National Research Medical University, Moscow, Russian Federation,   Russian Gerontological Research and Clinical Center of the Pirogov Russian National Research Medical University, Moscow, Russian Federation
Published: November 2023

Chronic pain syndrome is one of the most common geriatric syndromes, it has an impact on person’s self-management, worsens the life quality and shortens life expectancy. Reduced mobility, the need for external assistance due to chronic pain lead to an increase in the costs of the healthcare system. The peculiarity of the elderly and senile patient management with chronic pain is the need to assess not only the pain syndrome itself, but also polymorbid pathology and other geriatric syndromes that affect the pain pathogenesis. A patient-centered care for elderly persons with chronic pain, developed on the basis of a comprehensive geriatric assessment, should include interventions aimed at correcting geriatric syndromes, the range and activity of movements and the pain negative consequences. The drug treatment of pain syndrome is determined by its intensity and the risks of developing adverse events (especially in the case of nonsteroidal anti-inflammatory drugs). The most correct treatment tactics of chronic pain is the basic therapy indication for diseases that cause the pain development. KEYWORDS: chronic pain, geriatric syndromes, comprehensive geriatric assessment, osteoarthritis, autonomy, mobility, nonsteroidal anti- inflammatory drugs, symptomatic slow-acting drugs. FOR CITATION: Naumov A.V., Khovasova N.O., Polyanskaya A.R., Tokareva L.G., Tkacheva O.N. Chronic pain in elderly and senile patients: clinical recommendations and difficulties in real practice. Russian Medical Inquiry. 2023;7(10):680–686 (in Russ.). DOI: 10.32364/2587-6821- 2023-7-10-11.
Destructive course of multiple sclerosis under the mask of progressive multifocal leukoencephalopathy (case report)
Authors:   Moscow Regional Veteran's Hospital, Solnechnogorsk, Russian Federation, Ershova A.A. , Kotov A.S. ,   M.F. Vladimirskiy Moscow Regional Research and Clinical Institute, Moscow, Russian Federation
Published: November 2023

The article presents a retrospective case study concerning demyelinating disease in a 44-year-old female patient. The disease onset was in 2019 with minor clinical manifestations, however, it led to an exacerbation, clinically similar to acute disseminated encephalomyelitis, manifested by facial asymmetry, speech disorder, gait, and pelvic floor dysfunction. Diagnosis was significantly hindered, since the female patient herself was not sufficiently aware of the disease severity and was not interested in further treatment due to concomitant depressive disorder. The presented clinical case shows the importance of a multidisciplinary approach and the earliest possible diagnosis. Despite the fact that multiple sclerosis was suspected at the time of the disease's onset, diagnosis and treatment began only 2 years later, when persistent disabling disorders developed in female patient that required the use of a differential diagnostic sets with such nosologies as progressive multifocal leukoencephalopathy, acute disseminated encephalomyelitis, secondary encephalitis, levamisole-induced multifocal inflammatory leukoencephalopathy. The possibilities of laboratory and instrumental methods necessary for this disease verification were analyzed as part of the case study KEYWORDS: multiple sclerosis, progressive multifocal leukoencephalopathy, acute disseminated encephalomyelitis, differential diagnosis, case study FOR CITATION: Ershova A.A., Kotov A.S. Destructive course of multiple sclerosis under the mask of progressive multifocal leukoencephalopathy (case report). Russian Medical Inquiry. 2023;7(10):687–692 (in Russ.). DOI: 10.32364/2587-6821-2023-7-10-12.
Asthenia correction in a patient with acute lymphoblastic leukemia after allogeneic hematopoietic stem cell transplantation (case report)
Authors:   I.P. Pavlov First St. Petersburg State Medical University, St. Petersburg, Russian Federation, Polushin A.Yu. , Skiba Ya.B. ,   I.P. Pavlov First St. Petersburg State Medical University, St. Petersburg, Russian Federation, Smykova O.G. ,   I.P. Pavlov First St. Petersburg State Medical University, St. Petersburg, Russian Federation, Nikolaev I.Yu. ,   I.P. Pavlov First St. Petersburg State Medical University, St. Petersburg, Russian Federation, Eliseev N.A. ,   I.P. Pavlov First St. Petersburg State Medical University, St. Petersburg, Russian Federation, Abukov D.N. ,   I.P. Pavlov First St. Petersburg State Medical University, St. Petersburg, Russian Federation, Sokolov A.Yu. ,   I.P. Pavlov First St. Petersburg State Medical University, St. Petersburg, Russian Federation,   I.P. Pavlov Institute of Physiology of the Russian Academy of Sciences, St. Petersburg, Russian Federation
Published: November 2023

Asthenic syndrome is one of the most common conditions in the clinical practice of medical specialists having various therapeutic spheres The genesis of asthenic disorder is diverse and can be represented by cerebrovascular pathology, metabolic disorders, hypoxia of various origin, as well as intoxication. Asthenic syndrome can be diagnosed in 70–75% of patients with oncological pathology at various treatment stages. The article presents a case study concerning the asthenic syndrome progression in a patient with acute lymphoblastic leukemia (ALL) and its successful correction by metabolic therapy course. Case study pattern consist in the occurrence of this syndrome in the setting of multiple factors (infectious, metabolic, associated with intracranial hemorrhage) in the early period after hematopoietic stem cell transplantation (HSCT). The article provides a pathogenetic justification for the therapy indication with antihypoxants (cytochrome C) in patients with oncological pathology aimed at the asthenic syndrome correction in this patient cohort. Cytochrome C is a heme- containing protein of natural molecular origin. It is a participant in the process of cellular respiration and a regulator of redox processes in tissues. Successful correction of asthenic syndrome in patients with oncological pathology is an important task, the solution of which is of undoubted practical value KEYWORDS: asthenia, asthenic syndrome, cytochrome C, leukemia, transplantation, hematopoietic stem cell transplantation, antihypoxants, metabolic therapy FOR CITATION: Polushin A.Yu., Skiba Ya.B., Smykova O.G., Nikolaev I.Yu., Eliseev N.A., Abukov D.N., Sokolov A.Yu. Asthenia correction in a patient with acute lymphoblastic leukemia after allogeneic hematopoietic stem cell transplantation (case report). Russian Medical Inquiry. 2023;7(10):693–699 (in Russ.). DOI: 10.32364/2587-6821-2023-7-10-13.
Experience of using Actitropil in chronic cerebral ischemia: clinical follow-up results
Authors:   I.P. Pavlov First Saint-Petersburg State Medical University, St. Petersburg, Russian Federation, Andreyev V.V.
Published: November 2023

Background: chronic cerebral ischemia (CCI) is one of the most common diseases in modern medical practice. The possibility of using effective drug therapy is the research subject. Aim: to study the efficacy and safety of Actitropil in patients with CCI in clinical practice. Patients and Methods: 30 patients with CCI were examined within the framework of the program. The diagnosis was established on the basis of generally accepted clinical practice guidelines with verification of changes in brain structures during imaging diagnostics. During follow- up (before and after the treatment course), changes in the parameters of the MoCA Test, the EQ-5D, MFI-20 scales, the Rivermead Mobility Index, and the neurologic symptom severity were evaluated. To assess the safety of the studied drug, adverse events (AE) were recorded. Results: by the time the treatment was completed, a significant improvement was obtained with normalization of cognitive functions: the number of points scored in the MoCA Test increased statistically significantly from 25 (24;25) to 28 (27;28.5), p=0.000004. There was a significant increase in the values on the EQ-5D scale by the 2nd visit from 45 (37;53) to 86 (79;90) points, p<0.0001. Less marked, but statistically significant results were also achieved when assessing neurological manifestations according to the Rivermead Mobility Index (p=0.002). According to the results of comprehensive testing, there was a statistically significant decrease in the asthenia severity on the MFI-20 scale (total score) from 44 (37;47) to 22 (20;25), p=0.000002. The subjective severity scoring of neurological symptoms showed a decrease from 4 (3;5) (submaximal) to 2 (1;2) (minimum) points, p=0.000002. During therapy with the studied drug, AE which required dose reduction or drug withdrawal, as well as serious adverse events were not registered. Conclusions: therapy with Actitropil in a daily dose of 200 mg (divided into two doses), for 30 days led to a significant regression in the severity of CCI clinical manifestations: cognitive, motor and asthenic. The studied drug has a favorable safety profile. KEYWORDS: chronic cerebral ischemia, cognitive functions, life quality, Rivermead Mobility Index, nootropics. FOR CITATION: Andreyev V.V. Experience of using Actitropil in chronic cerebral ischemia: clinical follow-up results. Russian Medical Inquiry. 2023;7(10):620–624 (in Russ.). DOI: 10.32364/2587-6821-2023-7-10-2.
Prospects for the use of therapeutic transcranial magnetic stimulation in diabetic polyneuropathy
Authors:   Academy of Postgraduate Education of the Federal Scientific and Clinical Center of the Federal Medical Biological Agency of Russian Federation, Moscow, Russian Federation, Bobrov M.P. , Ekusheva E.V. ,   Academy of Postgraduate Education of the Federal Scientific and Clinical Center of the Federal Medical Biological Agency of Russian Federation, Moscow, Russian Federation,   Belgorod State University, Belgorod, Russian Federation, Voitenkov V.B. ,   Academy of Postgraduate Education of the Federal Scientific and Clinical Center of the Federal Medical Biological Agency of Russian Federation, Moscow, Russian Federation,   Children's Research and Clinical Center of Infectious Diseases of the Federal Medical- Biological Agency, St. Petersburg, Russian Federation, Khozhenko E.V. ,   Academy of Postgraduate Education of the Federal Scientific and Clinical Center of the Federal Medical Biological Agency of Russian Federation, Moscow, Russian Federation
Published: November 2023

This article examines promising areas of therapeutic transcranial magnetic stimulation (TMS) for the treatment of diabetic polyneuropathy (DPN) — a common complication of diabetes mellitus, which significantly reduces the life quality of patients. Conservative therapy of this condition is not always effective; therefore, the article discusses alternative treatment methods, including TMS — a method in which magnetic induction is used to affect the brain structures. TMS use for the DPN treatment has shown certain positive results. The article discusses various aspects of the TMS use, including protocols, treatment duration, dosage and safety. A review of existing Russian and foreign studies with recommendations on the TMS use in clinical practice for the DPN treatment is being conducted. These studies demonstrate the potential of using TMS as an additional treatment method of DPN. However, there is a need in further clinical studies for a deeper understanding of the TMS efficacy and mechanisms of action in this disease. TMS use in the DPN treatment may represent a new direction in the field of therapeutic methods that contribute to improving the patient lives with diabetes mellitus. KEYWORDS: diabetes mellitus, complications, diabetic polyneuropathy, neuropathic pain, rhythmic transcranial magnetic stimulation, conservative therapy FOR CITATION: Bobrov M.P., Ekusheva E.V., Voitenkov V.B., Khozhenko E.V. Prospects for the use of therapeutic transcranial magnetic stimulation in diabetic polyneuropathy. Russian Medical Inquiry. 2023;7(10):625–629 (in Russ.). DOI: 10.32364/2587-6821-2023-7-10-3.
Efficacy and safety of Renobrain® СМ in patients with chronic cerebral ischemia
Authors:   Academy of Postgraduate Education of the Federal Scientific and Clinical Center of the Federal Medical Biological Agency of Russian Federation, Moscow, Russian Federation, Ekusheva E.V. ,   Belgorod State University, Belgorod, Russian Federation, Voitenkov V.B. ,   Academy of Postgraduate Education of the Federal Scientific and Clinical Center of the Federal Medical Biological Agency of Russian Federation, Moscow, Russian Federation,   Pediatric Research and Clinical Center for Infectious Diseases under the Federal Medical Biological Agency, St. Petersburg, Russian Federation
Published: November 2023

Aim: to study the efficacy and safety of bovine cerebral cortex polypeptides (BCCP) in patients with chronic cerebral ischemia (CCI). Patients and Methods: an open multicenter randomized prospective comparative clinical trial was conducted with the participation of 40 patients with CCI (ICD-10: 167.8) aged 55 to 75 years, having risk factors for cerebrovascular pathology (hypertension, obesity, dyslipidemia or atherosclerosis) and vascular brain damage (according to the data of MRI, the STRIVE v1 protocol). After randomization, main group (n=20) received standard therapy for the underlying disease and Renobrain® СМ 10 mg/day, intramuscularly, for 10 days. Control group (n=20) received only standard therapy of the underlying disease. Clinical and neurological examination was performed using international questionnaires to assess cognitive and functional disorders before and after the therapy course in 30–32 days (Schulte and DSST tests, asthenic state and life quality SF-36 scales). Results: the BCCP, in addition to standard therapy in patients with CCI contributed to a statistically significant (p<0.05) improvement in cognitive functions (volume; refocusing rate; concentration and vigilance; working memory; information processing speed; executive, neurodynamic and regulatory functions), increased exercise tolerance, reduced mental fatigue and improving the life quality. The positive changes that occurred during treatment in the main group were probably related to the GABAergic effect, relationship normalization of the excitatory and inhibitory amino acids and mediators in the central nervous system, which leaded to functional restoration of neuronal cerebral systems. Conclusion: BCCP use in the complex therapy of patients with CCI is pathogenetically justified. Given its neurotrophic effect along with a high safety profile, repeated courses of such a drug and its wider use in patients with vascular brain damage can be recommended. KEYWORDS: chronic cerebral ischemia, cerebrovascular diseases, cognitive disorder, asthenia, bovine cerebral cortex polypeptides. FOR CITATION: Ekusheva E.V., Voitenkov V.B. Efficacy and safety of Renobrain® СМ in patients with chronic cerebral ischemia. Russian Medical Inquiry. 2023;7(10):666–671 (in Russ.). DOI: 10.32364/2587-6821-2023-7-10-9.
IoT intrusion detection system using ensemble classifier and hyperparameter optimization using tuna search algorithm
Authors: Vijayan P. M. , Sundar S.
Published: November 2023

The Internet of Things (IoT) is a dynamic and delightful research field in this emerging technology. It can be globally connected with many IoT devices and exchange a large amount of data. However, the threats also developed and misguided the entire network’s behaviour. This article proposes an Intrusion Detection System (IDS) using the proposed ensemble classifier along with the Tuna Swarm Optimization (TSO) to fine-tune the hyperparameters and help to enhance the detection accuracy of attacks that take place in IoT environment. Here, the publicly available message queue telemetry transport (MQTT) network dataset is used to classify the given data into the following categories: SlowlTe, malformed, brute force, flood, DoS, and legitimate. Initially, the dataset is pre-processed to remove possible outliers, then data balancing is performed using the Synthetic Minority Oversampling Technique (SMOTE) technique and features are extracted with the help of Recursive Feature Elimination (RFE). Finally, ensemble classifier along with the optimized parameters using TSO helps in detecting the attacks in IoT attacks. The proposed TSO-ensemble classifier achieved a classification accuracy of 99.12%. In contrast, the classification accuracy of the existing Improved Vulture Starvation-based African Vultures Optimization (IVS-AVOA) and Convolutional Neural Network Long Short-Term Memory (CNN-LSTM) have achieved a classification accuracy of 96.61% and 98.94% respectively.
Primary extragonadal yolk sac tumor of the orbit: A rare case and review of literature
Authors: Bhanvadia Viral M , Shah Ami
Published: November 2023

Germ cell tumors usually arise from primordial cells in gonads, mainly testes, and ovaries. Extragonadal involvement of orbit is very unusual. We report one case of primary yolk sac tumor of orbit in a 3-year-old male child presented as a left lateral orbital mass. Its clinical presentation may mimic many common pediatric orbital tumors causing misdiagnosis which affects ocular morbidity and mortality. Awareness about this rare entity to clinicians is helpful in the early diagnosis and proper management of young kids.
Liver mass masquerading as adrenal space-occupying lesion: A rare presentation
Authors: Mishra Jagamohan , Choudhury Sunirmal , Kundu Gourab , Sinha Subham
Published: November 2023

Adrenal pseudotumors have been described in the literature; however, liver mass masquerading as adrenal space occupying lesion is a rare entity. Here, we describe the case of a 40-year-old female who presented with right-sided abdominal pain for 1 year and was provisionally diagnosed as non-functioning adrenal adenoma after evaluation. She was planned for laparoscopic adrenalectomy. On laparoscopy, a mass arising from the liver was found. The procedure was abandoned and a computed tomography-guided tru-cut biopsy of liver mass was done, which showed the feature of benign liver tissue suggestive of hepatic adenoma. Later, she underwent an excision of the liver mass. Adrenal pseudotumor should always be kept in mind during surgery for any suspected adrenal mass.
Enfeksiyon Hastalıklarında Ferroptozun Rolü
Authors: İSKİN Ali Eren , BUDAK Ferah
Published: November 2023

Glutatyon (GSH) ve glutatyon peroksidaz 4 (Glutathione peroxidase 4; GPX4) gibi lipid onarım sistemleriyle kontrol edilen ve çoklu doymamış yağ asidi (polyunsaturated fatty acids; PUFA) biyosentezini de kapsayan, bir dizi enzimatik reaksiyon ile korele olan ölüm tipine ferroptoz adı verilir. Ferroptoz aynı zamanda, ferröz (Fe+2) demire bağımlı hücre ölüm tipi olarak tanımlanmıştır. Apoptoz, piroptoz, otofaji gibi diğer hücre ölüm yollarından farklı özellikler gösterir. Ferroptoz sırasında gözlemlenen en önemli morfolojik özellikler; mitokondride gözlenen küçülme ve membran yoğunluğudur. Biyokimyasal özellikler ise, hücre içi serbest demir miktarındaki artış ve lipid peroksidasyonudur. Ferroptoz, nörodejeneratif hastalıklar ve kanser gibi hastalıkların ortaya çıkmasında ve gelişiminde önemli rol oynaması nedeniyle çok sayıda araştırmanın odak noktası haline gelmiştir. Bu hastalıkların yanı sıra; GPX4, GSH aktivitesinde azalma ve ortamda reaktif oksijen türlerinin (ROT) birikimi gibi olaylar ile birçok enfeksiyon hastalığında da ferroptoz süreci görülebilmektedir.
Hubungan karakteristik individu, gejala kelelahan subjektif, kompetensi, persepsi ketersediaan alat pelindung diri terhadap kecelakaan kerja pekerja Mechanical Electrical Plumbing (MEP)
Authors: Maharani Nabila , Setyaningsih Yuliani , Widjasena Baju
Published: November 2023

A work accident is an unexpected event that can cause human casualties and property damage. According to data from the Ministry of PUPR in 2017, many work accidents occurred in the construction sector. Thus, Occupational Safety and Health are needed by construction sector workers in minimizing the occurrence of work accidents. Analyzing the relationship between characteristics, subjective fatigue symptoms, competence, and perceptions of PPE availability on the incidence of work accidents in MEP Construction Project PT. X, Jakarta. Quantitative with cross sectional design. The sample size was 68 people using the total sampling method which was then analyzed by chi-square statistical analysis. The results of the bivariate analysis in this study indicate that there is a relationship between age, length of service, subjective fatigue symptoms, competence, and perceptions of PPE availability to work accidents. But there is no relationship between the type of work on work accidents. To minimize the occurrence of work accidents, management is expected to improve the quality of workers by conducting training for workers and optimizing the K3 program.