bluuebunny/crossref_metadata_2025 huggingface dataset:
Veus silenciades: tuberculosi, experiència d’una malaltia
Authors: Perich Martin Núria
Published: December 2023

Aquest article és una síntesi de la tesi doctoral del mateix títol que té per objectiu conèixer les experiències i vivències de les persones malaltes de tuberculosi durant el seu itinerari terapèutic. El context inicial d’aquesta investigació són els importants canvis sociodemogràfics que es varen produir l’any 2007 en la població de la ciutat de Barcelona, arran dels fenòmens migratoris de caràcter econòmic. L’estudi s’ha realitzat des d’una aproximació qualitativa, adoptant un enfocament fenomenològic interpretatiu, orientat a comprendre l’experiència viscuda. Les dades s’han recollit mitjançant dues tècniques d’investigació qualitativa: les entrevistes en profunditat i els grups focals. De l’anàlisi en profunditat dels relats dels pacients i dels professionals s’han obtingut uns resultats que s’han classificat en divuit categories, disset pertanyen a les persones malaltes i una a la visió dels professionals, i s’han agrupat en tres grans temàtiques. Per una banda, hi ha l’àmbit personal: malestars i significats de l’experiència corporal, sentiments i emocions, coneixement o desconeixement de la malaltia, contagi, creences religioses i projectes de vida. Per una altra, l’àmbit social: gènere, estigma, entorn laboral, aïllament i entorn social. I, finalment, l’àmbit sanitari: retard en el diagnòstic, comunicació i informació, adherència al tractament, percepció de la infermera, experiències amb el sistema sanitari català, experiències amb el sistema sanitari d’origen i la visió dels professionals Les conclusions es formulen a partir de cadascuna de les categories obtingudes. Finalment, es presenten unes recomanacions útils per a la pràctica quotidiana en l’entorn sanitari i social.
De la “mejor evidencia” a las “tensiones en el contacto”. Compactación de la evidencia científica en la literatura sobre intersexualidades de la Sociedad Española de Endocrinología Pediátrica (SEEP) en el periodo 2001-2019
Authors: Fernández Garrido Sam
Published: December 2023

La clínica intersexual del Estado español se ha visto interpelada por la emergencia de un sujeto político intersex, marcadamente presente en la escena pública a partir de 2020. Se trata de un conjunto plural de asociaciones u organizaciones cuyas demandas afectan y se disputan el sentido de los saberes y las prácticas clínicas expertas.
En este artículo exploro la relación entre la emergencia de dicho activismo y la formación de los saberes y prácticas quirúrgicas relacionados con uno de los objetivos de la clínica intersexual: la corrección de las genitalidades no estándares presentes en personas con determinadas variantes corporales intersex. Para ello exploro un conjunto de contribuciones científicas producidas durante las dos últimas décadas por uno de los actores médicos principales en el contexto de la clínica intersexual española: la SEEP (Sociedad Española de Endocrinología Pediátrica). Atendiendo a las fisuras que se producen respecto a la terapéutica dominante, tanto dentro de la comunidad médica como desde los activismos, este análisis atiende a las formas en que les profesionales de la SEEP han negociado las tensiones del contacto a través de prácticas que han producido una “compactación” de la evidencia científica, es decir, una evidencia más sólida y coherente de lo que sus fuentes parecen sustentar. Este análisis es útil para comprender la formación de la evidencia científica como parte de los procesos de transculturación que tienen lugar en las “zonas de contacto”.
El model de cura de llarga durada en transició: l’impacte de la covid-19 en l’organització familiar de la cura
Authors: Bodoque Puerta Yolanda , Soronellas Masdeu Montserrat
Published: December 2023

.
DNA Barcoding Standard Operating Protocol, Plants and Lichens at RBGE, Sample Data v1
Authors: L Forrest Laura , Bell David , Hart Michelle
Published: December 2023

This is part of the collection DToL Taxon-specific Standard Operating Procedures for the Plant Working Group (protocols.io). The SOP collection contains guidance on how to process the various land plant taxa within the scope of the Darwin Tree of Life project. The guidance specifically refers to the metadata associated with tissue samples for DNA barcoding (which takes place at the Royal Botanic Garden (RBGE)). Every specimen is submitted for DNA barcoding first before potentially being sent to the Wellcome Sanger institute for whole genome sequencing. This DNA barcoding SOP outlines the processing of plant and lichen sample data for the Darwin Tree of Life project (DToL) at the Royal Botanic Garden Edinburgh (RBGE). DNA barcoding is used as part of the species identification process AND sample tracking (to check that the genome sequence corresponds to the material that was sent and that there have been no sample mix-ups). Definition: Land plants (Embryophyta) and lichens Including: Bryophyta, Marchantiophyta, Anthocerotophyta, Lycopodiophyta, Polypodiophyta, Pinophyta, Cycadophyta, Ginkgophyta, Gnetophyta, Magnoliophyta, lichenized fungi Excluding: all non-lichenized fungi
Immunostaining Mouse Brain Tissue or Neuronal Cultures v1
Authors: Edwards Robert
Published: December 2023

This protocol describes immunohistochemical and immunoctyochemical methods to analyze protein expression in mouse brain. In the protocol, we describe the fixation of tissue or cultured neurons, the immunostaining procedure, and collecting images for analysis.
Colonic Migrating Motor Complexes v1
Authors: Griffiths Jessica
Published: December 2023

Protocol used in "Peripheral Neuronal Activation Shapes the Microbiome and Alters Gut Physiology"
Collections Standard Operating Protocol, Plant group: Bryophytes v1
Authors: L Forrest Laura , Hart Michelle , Bell David
Published: December 2023

This is part of the collection "DToL Taxon-specific Standard Operating Procedure (SOP) for the Plant Working Group". The SOP collection contains guidance on how to process the various land plant taxa within the scope of the Darwin Tree of Life project. The guidance specifically refers to the tissue samples needed for DNA barcoding (which takes place at the Royal Botanic Garden (RBGE)) and outlines the flash frozen tissues required for whole genome sequencing (WGS), which takes place at the Wellcome Sanger Institute . Every specimen is submitted for DNA barcoding first before potentially being sent to the Wellcome Sanger institute. This Sample Collection SOP outlines the collection of plant samples for the Darwin Tree of Life project. DToL aims to generate high quality genome sequences from these samples. To achieve this goal the DToL Genome Acquisition Labs (GALs) must access a sufficient quantity of healthy living material, preserve it in a manner that conserves its DNA quality, and supply it to the appointed sequencing facility. Material must also be available and appropriately preserved for DNA barcoding, flow cytometry and herbarium vouchers. In some instances, material for RNA extraction is also required. It is the responsibility of the GALs to also link accurate and information-rich metadata to all collections. Definition: Bryophytes. Including: Bryophyta, Marchantiophyta, Anthocerotophyta. Excluding:
Protocol for Neuronal Live-imaging of primary cultures v1
Authors: Pulido Camila , A. Ryan Timothy
Published: December 2023

Neurons stand out as remarkably intricate cells. The development of live-imaging techniques on primary neurons expressing genetically engineered biosensor has proven pivotal in advancing our comprehension of neuronal function at both cellularand molecular level. This protocol introduces a concise method for live-imaging neuronal activity.
Standardization of 3,5-dinitrosalicylic acid (DNS) assay for measuring xylanase activity
Authors: Božinović Marko , Sokač Tea , Šalić Anita , Dukarić Ana-Marija , Tišma Marina , Planinić Mirela , Zelić Bruno
Published: December 2023

The 3,5-dinitrosalicylic acid (DNS) assay has been used for many years mainly to determine the enzymatic activity of xylanase. The assay is based on the detection of reduced sugars. Although the method is widely used, several recent studies have questioned the accuracy of the method. They mainly focused on the detection of side reactions that could lead to a false positive result of the assay. In this study, the basic components of the DNS assay such as buffer preparation, substrate source and concentration, incubation time, reagent preparation, and activity calculation were re-evaluated. Potential problems were detected and a new assay procedure was proposed. Compared to literature data, the new assay is shorter because it avoids the generation of a calibration curve and takes into account the enzyme and substrate amount when calculating enzyme activity, which is neglected in current assays.
An Update Management of Pes Planus and Pes Cavus
Authors:   Department of Orthopaedic & Traumatology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Kuala Lumpur, Malaysia
Published: December 2023

This review article provided an update on managing pes planus and pes cavus, two common foot deformities caused by an imbalance of the forces acting on the foot. The article described the stages of adult-acquired flatfoot deformity and its causes, risk factors, and treatment options, including conservative and surgical approaches. The report also provided information on the clinical and radiological assessment of the condition and the use of various modalities such as orthotics and braces, physical therapy, and medication
Backbone Ground-Motion Models for Crustal, Interface, and Slab Earthquakes in New Zealand from Equivalent Point-Source Concepts
Authors: Atkinson Gail M.
Published: December 2023

A ground-motion model (GMM) that strikes a balance between empirical and simulation-based approaches is developed in support of the 2022 update of the New Zealand National Seismic Hazard Model. The development follows the backbone approach, comprising a central model to express the median ground motions for earthquakes in New Zealand (NZ), along with upper and lower alternatives to describe its epistemic uncertainty. Aleatory variability of ground-motion amplitudes about the median is also characterized. Separate GMMs are developed for crustal, interface, and in-slab earthquakes. The approach taken is to perform a regression analysis of the NZ response spectra database employing a functional form, concepts, and constraints that are drawn from equivalent point-source simulations. The model parameters that control the scaling of the GMM with magnitude and distance describe source effects (seismic moment and stress parameter), path effects (geometric and anelastic attenuation), and site effects (site shear-wave velocity). The NZ database provides constraints on the model for M ∼ 4–7, for frequencies from 0.2 to 100 Hz, at distances to ∼400 km. Extension of the GMM to larger magnitudes (M 7–9) is constrained by the Hassani and Atkinson seismological model, which was developed for application to events of M 3–9 and validated in data-rich regions (California for crustal earthquakes, Japan for interface and slab earthquakes).
Standardizing Earthquake Magnitudes for the 2022 Revision of the Aotearoa New Zealand National Seismic Hazard Model
Authors: Christophersen Annemarie , Bourguignon Sandra , Rhoades David A. , Allen Trevor I. , Ristau John , Salichon Jerome , Rollins John Christopher , Townend John , Gerstenberger Matthew C.
Published: December 2023

The 2022 revision of the New Zealand National Seismic Hazard Model—Te Tauira Matapae Pūmate Rū i Aotearoa—requires an earthquake catalog that ideally measures earthquake size in moment magnitude. However, regional moment tensor solutions, which allow the calculation of moment magnitude MwNZ, were introduced in New Zealand only in 2007. The most reported magnitude in the national New Zealand earthquake catalog is a variation of local magnitude ML. In New Zealand, ML is systematically larger than MwNZ over a wide magnitude range. Furthermore, the introduction of the earthquake analysis system SeisComP in 2012 caused step changes in the catalog. We address the problems by converting magnitudes using regressions to define a standardized magnitude as a proxy for MwNZ. A new magnitude, MLNZ20, has an attenuation relation and station corrections consistent on average with MwNZ. We have calculated MLNZ20 for nearly 250,000 earthquakes between 2000 and 2020. MLNZ20 is a reasonable proxy for MwNZ for earthquakes with ML<5.5. For earthquakes with ML>4.6, MwNZ is reliably available. We have applied ordinary least squares (OLS) regression for MwNZ and MLNZ20 on ML before and after 2012. We argue that OLS is the most appropriate method to calculate a proxy for MwNZ from individual ML measurements. The slope of the OLS regression compares well to the slope from the method of moments, which accommodates equation error that is present when there is scatter beyond measurement error, as is the case for our magnitude data. We have defined as a proxy for MwNZ a standardized magnitude Mstd, which is Mw when available, MLNZ20 with some restrictions as a second choice, and otherwise the magnitude derived from regression. Standardization of the magnitudes reduces the total number of earthquakes with a magnitude of ≥4.95 by more than half and corrects step changes in the spatial distribution of earthquakes between 2011 and 2012.
Desarrollo de la clínica médica de la Facultad de Veterinaria de León durante el decenio 1974-1984
Authors: IPSUM LOREM
Published: December 2023

.
Tratamiento quirúrgico de granuloma ótico en tortuga de tierra (Testudo Graeca)
Authors: E. Serantes Gómez Alicia , Vázquez Díez Carlos , Barreiro Lois Andrés , Luis Pereira Espinel José , Manuel Gonzalo Cordero José , Escudero Díez Alfredo
Published: December 2023

El presente trabajo describe la intervención quirúrgica de eliminación de un granuloma parasitario por Sarcocystis sp. en la cabeza de una tortuga de tierra "Testudo graeca" hembra de 10-15 años de edad.
Estudio de la prolificidad en los cruzamientos realizados entre líneas divergentes de selección en el ratón
Authors: Bayón González Yolanda , San Primitivo Tirados Fermín , Fuente Crespo Luis  Fernando de la
Published: December 2023

Se realizó un estudio de la prolificidad en los cruzamientos programados entre líneas de ratón seleccionadas en dirección divergente. Dos líneas habían sido seleccionadas para aumentar (W+) y disminuir (W¿) el peso corporal a los 42 días. Otras dos líneas habían sido seleccionadas para aumentar (L+) y disminuir (L¿) el tamaño de las tres primeras camadas. Se analizaron los efectos genéticos directo, materno y de heterosis para los caracteres tamaño de la primera camada y tamaño de las tres primeras camadas (TN-3). Los resultados parecen indicar que los efectos genéticos aditivos y no aditivos para el carácter TN-3 se encuentran en la línea de los obtenidos generalmente para el tamaño de la primera camada.
Cinética de la reducción de la acetoina por la L-Glicol Deshidrogenasa (NAD+) de Enterobacter Aerogenes
Authors: Isabel Vidal González María , Javier Carballo García Francisco , Martín Sarmiento Roberto , Bernardo Álvarez Ana , González Prieto Josefa
Published: December 2023

Se estudia la cinética de la reducción reversible de la acetoína a 2,3-butanodiol por la L-glicol deshidrogenasa (NAD+) de Enterobacter aerogenes. Los resultados obtenidos ponen de manifiesto que las reacciones tienen lugar por un mecanismo Ordenado Bi-Bi en el que el coenzima opera como sustrato "conductor". La enzima presenta una alta afinidad por el NADH y la acetoína y menor por el NAD y el 2,3-butanodiol.
Farmacocinética clínica del levamisol en el conejo. I
Authors: José Díez Liébana María , Teresa Terán M. , José García Vieitez Juan , Sierra Vega Matilde
Published: December 2023

En el presente trabajo estudiamos la absorción oral del levamisol en el conejo. Para ello utilizamos quince conejos New Zealand blancos y se les administró levamisol a razón de 12,5; 16 y 20 mg/kg. Las concentraciones plasmáticas del levamisol se determinaron por cromatografía líquida de alta eficacia y el tratamiento de los datos experimentales se hizo de acuerdo a un modelo bicompartimental abierto con un proceso de absorción de primer orden. La velocidad del proceso de absorción fue moderada como indican los tiempos en que se alcanzaron las concentraciones máximas: 30 minutos para la dosis de 12,5 mg/ kg y 60 minutos para las dosis de 16 y 20 mg/kg. Asimismo las concentraciones máximas observadas fueron 0,68; 1,12 y 1,50 µg/ml respectivamente.
Estudio de la estructura genética de una población ovina de raza churra para algunos polimorfismos sanguíneos
Authors: Bayón González Yolanda , San Primitivo Tirados Fermín , Arranz Santos Juan José
Published: December 2023

Se realiza una estimación de la variabilidad genética de una población ovina de raza Churra compuesta por 255 animales mediante el análisis electroforético de los siguientes sistemas genéticos sanguíneos: hemoglobina, enzima málico, NADH- diaforasa, purina nucleósido fosforilasa, anhidrasa carbónica, transferrina, albúmina y arilesterasa. Todos los loci analizados resultaron polimórficos. No se encontró desviación significativa de la población del equilibrio Hardy-Weinberg. Los valores obtenidos de la heterocigosis por locus fueron variables, resultando una tasa de heterocigosis media en la población H = 0,350 ± 0,069.
Morfopatología y prevalencia de las irregularidades del crecimiento endometrial en bovinos sacrificados en matadero
Authors: José García Iglesias María , Manuel Martínez Rodríguez José , María Bravo del Moral Ana , Del Carmen Ferreras Estrada María , Escudero Díez Alfredo
Published: December 2023

Se realiza un estudio morfopatológico y estadístico de las alteraciones del crecimiento endometrial diagnosticadas en un estudio de 1.489 hembras bovinas sacrificadas en matadero. La prevalencia de la adenomiosis fue de 0'2%. Dentro de las razas, las más afectadas fueron las mestizas, y dentro de los grupos de edad, las mayores de 15 años. Consideramos que esta alteración es el resultado de una malformación. La frecuencia de la hiperplasia endometrial quística (HEQ) fue del 6%, con una mayor presentación en las hembras mestizas, y dentro de los intervalos de edad, de 11 a 15 años. Comprobamos que esta lesión aparecía relacionada con los quistes foliculares, tumores de células de la granulosa, mucómetra e hidrómetra, provocando además infertilidad.
Estadísticas clínicas del servicio de cirugía y radiología de la clínica de la Facultad de Veterinaria de León pertenecientes al curso académico 1990-1991
Authors: Fernández Martínez Manuel , Sánchez García Jesús , Vázquez Díez Carlos , Asunción Orden Recio María , E. Serantes Gómez Alicia , Manuel Gonzalo Cordero José , Manuel Gonzalo Orden José , Del Río Lozano José
Published: December 2023

En el presente trabajo se realiza un estudio estadístico de la actividad Quirúrgica y Radiológica en la Consulta Pública de la Facultad de Veterinaria de León durante el Curso Académico 1990-91, considerando los siguientes aspectos: Fecha de atención, especie, raza, sexo, edad, procedencia y tipo de intervención.
Queso de vaca de León. Fracciones nitrogenadas y aminoácidos libres
Authors: Javier Carballo García Francisco , María Fresno Baro José , Martín Sarmiento Roberto , Bernardo Álvarez Ana , Prieto Gutiérrez Bernardo
Published: December 2023

Se ha realizado un estudio de la distribución del nitrógeno, y de los aminoácidos libres, en el "Queso de vaca de León" al término de la maduración. Los valores obtenidos para las distintas fracciones nitrogenadas ponen de manifiesto que este queso sufre una proteolisis escasa. El tipo de cuajo utilizado (artesanal o comercial) afecta a la intensidad de la degradación proteica, que es mayor en los quesos elaborados con cuajo comercial. Utilizando este tipo de cuajo, los aminoácidos libres más abundantes son la fenilalanina, la glutamina y la leucina + isoleucina, y los menos, la asparagina y la glicina. El perfil de los aminoácidos libres en los quesos elaborados con cuajo artesanal es muy similar aunque presenta cifras más bajas de algunos aminoácidos relacionados con el desarrollo del aroma.
Hiperinsulinismo en un perro
Authors: Belén García Rodríguez María , Javier Alonso Díez Ángel , César Pérez García Carlos , García Partida Paulino , Inmaculada Diez Prieto M.
Published: December 2023

Se comentan los aspectos clínicos y el protocolo diagnóstico seguido en un caso de hiperinsulinismo en perro. Se presentan los resultados de glucemia e insulinemia, sus relaciones y su evolución durante la prueba de tolerancia al glucagón.
Un método para la diferenciación específica de huevos de nematodos gastroentéricos ovinos
Authors: Castañón Ordóñez Luciano , Reguera Feo Antonio
Published: December 2023

Proponemos un método para la diferenciación específica de huevos de nematodos gastroentéricos ovinos, basado en una función discriminante que usa como parámetros la longitud y anchura de los huevos. El estudio fue realizado en un rebaño de ovejas lachas en régimen extensivo en el Valle de Campoo (Cantabria). Los huevos se obtenían de heces en las que se conocía la presencia de una sola especie. Nuestro método tiene una mejor capacidad discriminante que los métodos gráficos descritos y sin necesidad de infraestructura informática. Por otra parte, es menos laborioso que el método basado en la identificación de larvas de tercer estadio.
Efecto de la temperatura de descongelación sobre la viabilidad in vitro del semen congelado de morueco
Authors: Carlos Domínguez Fernández de Tejerina Juan , Anel Rodríguez Luis , García Díez Carmen , Teresa Carbajo Rueda María , Oscoz Cuñado A.
Published: December 2023

En el presente trabajo de investigación, se estudia la influencia del uso de distintas temperaturas de descongelación (5°C durante un periodo de tiempo de 2 min, 40°C durante 10 seg y 65°C durante 6 seg), sobre la viabilidad del semen descongelado de morueco, cuantificada mediante la determinación de la motilidad, la integridad acrosómica y el test de endósmosis celular.
Influencia del ph del medio de esporulación sobre los parámetros de resitencia al calor para Bacllus cereus
Authors: González Prieto Josefa , González Martínez Isaac , López Fernández Mercedes , Martín Sarmiento Roberto , Mazas Alberdi Margarita
Published: December 2023

Se investigó la resistencia al calor de los esporos de la cepa ATCC 4342 de Bacillus cereus a diferentes pHs de esporulación. El pH del medio afectó notablemente a los valores D, con diferencias en los casos más extremos de hasta unas seis veces. El pH de esporulación al que se obtuvieron los esporos más termorresistentes fue muy dependiente del medio utilizado, 7,5 en agar nutritivo y 6,2 en el medio de Angelotti. Los valores z no resultaron afectados.
Effect of Fungicides in Controlling Alternaria Blight of Cumin
Authors: Khalequzzaman K. M.
Published: December 2023

The experiment was conducted at Spices Research Centre, BARI, Shibganj, Bogra, Bangladesh during 2014-15 to find out the effective fungicides in controlling Alternaria blight of cumin. Four fungicides viz. Rovral 50 WP @ 0.2%, Companion @ 0.2%, Secure 600 W @0.15%, Sunvit 50 WP  @0.5% and one control were used as treatment. Cumin line CN 026 was used in this experiment. Three fungicides reduced disease significantly over control. Alternaria blight ranged from 14.40 - 90.81%, while the lowest severity was recorded in Rovral 50 WP (0.2%) sprayed plots and the highest severity was recorded in control treatment. Rovral 50 WP (0.2%) gave the highest number of umbels/plant, number of umbel lets/plant, number of seeds/umbel, number of seeds/plant, weight of seeds/plant and seed yield (675.0 kg/ha) which was followed by Companion and Secure 600 W. Sunvit and control treatment did not produce any seeds.
Translanguaging: A Culturally Responsive Pedagogy
Authors: White Melinda
Published: December 2023

Translanguaging empowers non-native English speakers in the use and maintenance of their first language. Using their entire linguistic repertoire, English language learners (ELLs) will be able to express themselves better in speech and writing. Support for their home language will increase overall linguistic ability but will also help them maintain connections to their heritage and families and allow them to continue to identify with and be proud of their cultural roots. Opposition and prejudice against the use of languages other than English should be examined and rooted out for the racist ideology it is.
Over -identification of English language learners in special education during COVID-19
Authors: Kim Eunjoo , Kang Jeongae
Published: December 2023

This study surveyed teachers’ perceptions of English learners (ELs) and their referrals to special education during the COVID-19 pandemic. Limited social interactions during the pandemic greatly affected ELs’ language and social development. Using an online survey, the study identified how teachers perceived the impact of the COVID-19 pandemic on ELs, particularly changes in their areas of struggle before and after the pandemic, and the connection between their struggling due to the lockdown and special education referrals. This survey was distributed to Indiana public schools and targeted K–3 teachers. The results indicated that almost 25% of the teachers reported an increase in ELs’ referral to special education referrals after the school lockdown. Further, the teachers indicated an increase in reports of Els with behavior issues and emotional struggles compared to the pre-pandemic period.
Reducing the all aspect angle radar visibility of the receiving-transmitting system operating in the direction of the ELINT system
Authors: Azizov A.G. , Khlopov B.V. , Kolesnikov N.P.
Published: December 2023

Formulation of the problem. At present, in the field of radio electronics, an intense antagonistic struggle is constantly taking place for the creation of concealed RES with reduced radar visibility in conditions of radio-electronic suppression. In this regard, in developed industrial countries, approaches are intensively developed and improved based on the theoretical possibility of creating in the aperture of any antenna compensating for useful information by an interference electromagnetic field. Therefore, there was an urgent need for a logical and methodological procedure for estimating the local characteristics of the radar visibility of objects and identifying critically important optimal and effective distinctive properties, connections, as well as assigns and indicators that characterize innovations. Goal. Identification of critical properties reducing radar visibility transceiver systems operating in the dynamic space of the EMF in the direction of the ELINT system, flying around the radar and receiving emission signals from any point in space. Results. An approach has been developed to assess the local characteristics of the radar visibility of objects and a model of a monopulse radar has been proposed using technological, circuitry and design properties that make it possible to reduce radar visibility and design promising radars, EMF operating in the dynamic space in the direction of the ELINT system. Practical significance. The application of the developed approach to the design of RES allows us to increase efficiency in terms of simulating interference that reduces the visibility of the radar when operating in "direct mode".
Detection of unauthorized cell phone use during exam
Authors: Loskutov V.Iu. , Mudrik D.S. , Slukin G.P.
Published: December 2023

In this article algorithm for detecting and determining the position of signal source produced by an active subscriber terminal of a cellular communication system GSM standard is introduced. Also there are presented results of simulation of the detection system operation and results of experiments on monitoring the signal spectrum of an active subscriber GSM cellular communication system.
Recent advances in anticancer drug discovery: A review
Authors: Tadesse Alemu , Nemomsa Kuleni , Beyene Frehiwot
Published: December 2023

Cancer is a process of uncontrolled cell proliferation that leads to the development of an abnormally growing tumor, determining initially a local disease that might spread, impairing other organs or important processes. One of the most fatal diseases in recent times, cancer kills many lives each year. The effective management of this condition has been impacted by the variances in the disease across the globe, the impact of the medical facilities that are available, and other socioeconomic issues. The aim of this study was to summaries previously published articles regarding recent advances in anticancer drug discoveries. In this review, previously published literature regarding recent advances in anticancer drug discovery collected from journals through PubMed Central, Google Scholar, and Science Direct from March 20 to May 12 was identified well, and points that I assumed were important and recent (2017–2023) were included.Based on my searches, numerous discoveries are identified and grouped as anticancer drug targets, plant derived advances, chemical compounds with in vivo or in vitro cytotoxic drug discovery, and repurposing advances. Based on a variety of articles published by scholars, this review summarizes some recent advancements in anticancer drug discovery. Under this broad topic, promising and clinically evidenced drug targets for anticancer drug binding, some drugs repurposed for cancer treatment, plant-derived advances in cancer therapy, and finally advances in novel chemical compounds in the area of cancer therapy are reviewed.
Synthesis, crystal structure studies, characterization and study of novel heterocyclic thiadiazoles as caspase 3 inhibitors for anticancer activity
Authors: Gharia Bhavini K , Suhagia Bhanubhai N , Jain Vineet
Published: December 2023

In the present study we have reported the synthesis of some novel heterocyclic derivatives comprising imidazole and 1,3,4-thiadiazole containing cyclopropyl moiety. Imidazothiadiazoles are of interest because of their diverse biological activities and clinical applications. Primarily docking studies are carried out with reference structure Pdb code:2DKO. We have reported the new series of 5,6 diaryl substituted with imidazo[2,1- b], , thiadiazoles analogs to target caspase family cysteine proteases. The reaction was monitored by Thin-layer chromatography using suitable mobile phase. The Rf values were compared and determined the melting point of synthesized compounds. Further these derivatives were characterized and confirmed by IR, 1H-NMR, 13C-NMR, and Mass spectral (MS) studies. For anticancer activity, all the selected compounds submitted to National Cancer Institute (NCI) for in vitro anticancer assay were evaluated for their anticancer activity. Primary one dose anticancer assay was performed in full NCI 60 cell panel in accordance with the protocol of the NCI, USA. The compounds and showed good activity against all cancer cell lines. The synthesized drugs were monitored with Caspase 3 inhibitor kit.(CASP3C-1KT)using colorimeteric assay.
Knowledge, attitude and practice of self-administered insulin by diabetes mellitus patients: A cross sectional study
Authors: Parmar Akshay Hasmukhbhai , Sukhlecha Anupama , Katariya Kajal Jasubhai
Published: December 2023

Diabetes mellitus is a heterogeneous clinical syndrome secondary to defects in insulin secretion, action, or both. India is emerging as the world's diabetic capital. Inadequate awareness about the use of insulin is likely to influence its acceptance and adherence.

To assess the knowledge, attitude, and practice (KAP) of self-administered insulin by patients of diabetes mellitus.

It was a cross-sectional study conducted by the department of pharmacology at a tertiary care teaching hospital over a period of six months at the medicine outpatient department. A prevalidated questionnaire was used to assess the KAP of insulin use. Informed consent was obtained from the patients prior to giving them a questionnaire.

Among the 151 responses, 58 were male and 93 were female. Among them, 66% knew about different types of insulin, and 32% knew about different insulin delivery devices. Around 40% of patients were not aware of HbA1c as a monitoring tool. Nearly 48% patients knew the complications of diabetes. Half of the patients were confident about the self-administration of insulin. About 54% patients took insulin for treatment. Among current insulin users, 75% injected insulin at the upper arm, 83% missed insulin doses, 74% had never used a glucometer, and 32% failed to rotate the site.

Knowledge and attitude were good in the majority of patients, but practice regarding the use of insulin was poor. Skilled health care providers could educate diabetes mellitus patients on self-care management and insulin self-therapy and bridge this gap.
Processing of secondary radiation and cosmic ray data measured at flight altitudes with the pixel detector Timepix
Authors: Salazar Reinoso María del Carmen S
Published: December 2023

Experimental data of the secondary radiation field and cosmic rays inside passenger aircraft in the atmosphere at airline altitudes (10-12 km) were processed. High-resolution data were measured by the semiconductor pixel detector Timepix operated in a miniaturized radiation camera MiniPIX-Timepix. The detector provides precise characterization with quantum sensitivity in terms of deposited energy and visualization of the charged particle radiation and X-ray field. The data were processed at the pre-processing and processing level with an integrated SW tool (Data Processing Engine-DPE). Results and physics data products consist of particle flux, dose rate, deposited energy, deposited dose, field composition into broad particle classes (protons, electrons, X-rays) as well as detailed visualization of the radiation field with quantum imaging registration of single-particle tracks. In this work, the detailed analysis of two measurements, as well as comparative graphs of selected results between ten flights are presented. Results of the total absorbed dose are compared with values measured also by Timepix detectors on ground and in LEO orbit onboard a satellite.
The catechumenate as a source of inspiration for catechesis in light of the Directory for Catechesis
Authors: Lemek Katarzyna
Published: December 2023

Postępujące w Polsce procesy laicyzacji, szczególnie dotyczące najmłodszego pokolenia wchodzącego w dorosłość, powinny prowadzić do zakwestionowania skuteczności tradycyjnego modelu duszpasterstwa skoncentrowanego na szkolnej nauce religii i oddziaływaniu na praktyki sakramentalne. Na podstawie analizy Dyrektorium o katechizacji i wcześniejszych dokumentów katechetycznych w artykule ukazano model katechumenalny jako ten, który ma pomóc doprowadzić już ochrzczonych do wiary dojrzałej. Studium tematu pozwoliło na sformułowanie wniosku, że katechumenat ponowny (pochrzcielny), uwzględniający indywidualną sytuację człowieka jest procesem formacyjnym trwającym całe życie oraz postulatu o pilne wypracowanie nowych modeli wprowadzania w chrześcijaństwo w oparciu o styl i dynamikę tej instytucji.
ЗМІЦНЕННЯ ТА ПІДВИЩЕННЯ ЗНОСОСТІЙКОСТІ РОБОЧИХ ОРГАНІВ СІЛЬСКОГОСПОДАРСЬКИХ МАШИН КОМПОЗИЦІЙНИМИ ПОКРИТТЯМИ ДИСКРЕТНОЇ СТРУКТУРИ
Authors: Шамрай  Віталій , Мікосянчик Оксана , Забойкіна Наталія
Published: December 2023

Розглянуто вплив поверхонь робочих органів сільськогосподарських машин з покриттям дискретної структури, що має рельєф у вигляді півсфер, на руйнування та подрібнення зернової сировини. Показано, що робоча поверхня ріжучих та дроблячих елементів з покриттям дискретної структури та з рельєфом у вигляді напівсфер може бути ефективнішою при подрібненні зернової сировини. Наводяться теоретичне обґрунтування і результати експериментів при подрібненні зерна пшениці ріжучими та дроблячими елементами, що мають робочу поверхню з покриттям дискретної структури.
СТАТИСТИЧНИЙ АНАЛІЗ РЕЗУЛЬТАТІВ ДОСЛІДЖЕННЯ ТРИБОТЕХНІЧНИХ ХАРАКТЕРИСТИК МАСТИЛЬНИХ МАТЕРІАЛІВ ПРИ ТЕРТІ
Authors: Якобчук Олександр , Юцкевич Святослав , Кисельова  Тетяна , Якобчук Іван , Сидоренко  Кирило
Published: December 2023

Ефективні мастильні матеріали відіграють вирішальну роль у забезпеченні безперебійної роботи обладнання в різних галузях промисловості, таких як авіація, машинобудування та автомобілебудування. Їх значення полягає в підвищенні експлуатаційної ефективності, зменшенні часу простою через поломки обладнання та продовженні терміну служби машин. Метою дослідження було оцінити триботехнічні параметри, що впливають на знос у парах тертя, зосередившись на антифрикційних та протизносних властивостях мастил Aero Shell Grease 33 та ВНІІНП-286М. За допомогою установки СМЦ-2 в режимі реального часу проводився моніторинг показників трибоконтакту, таких як момент тертя, швидкість обертання роликів і температура мастила. Регресійний і дисперсійний аналіз ANOVA викоанано за допомогою програмного забезпечення Statgraphics Centurion. Регресійні моделі корелювали знос зі змінними, такими як робота тертя, товщина шару мастила, коефіцієнт тертя, контактне навантаження і проникнення. Покрокова регресія усунула несуттєві змінні, підвищивши точність прогнозної моделі. ANOVA підтвердив значущість моделі. Дослідження підкреслило практичну застосовність статистичних інструментів для оптимізації ефективності мастильних матеріалів і надійності обладнання, проливаючи світло на ключові змінні, що визначають поведінку зносу в системах тертя.
BİST Bilişim Sektörü Firmalarının Finansal Sağlamlığının Finansal CEMATT Yöntemi ile İncelenmesi
Authors: Çalış Nevzat , Sakarya Şakir
Published: December 2023

Günümüzde bilişim sektörü her yıl artarak büyüyen ve önemi artan bir sektör haline gelmiştir. Bilişim sektöründeki hızlı gelişmeler, sadece kendi sektörünü değil beraberinde diğer sektörleri de şekillendirmekte ve her geçen gün yeni sektörlerin doğmasına sebep olmaktadır. Bu çalışmada BİST Bilişim sektöründe faaliyet gösteren firmaların finansal sağlamlığının Finansal CEMATT yöntemi ile analizi amaçlanmıştır. Bu bağlamda bilişim sektöründe faaliyet gösteren 27 firmanın 2018-2021 dönemi verilerinden yararlanılarak analiz yapılmıştır. Yapılan analiz sonucunda incelenen dönemler itibariyle finansal sağlamlık açısından sektördeki en başarılı firmalarının DESPC ve ARDYZ olduğu tespit edilirken, en başarısız firmaların ise MOBTL, MANAS ve NETAS firmalarının olduğu tespit edilmiştir.
Anahtar Kelimeler: BİST Bilişim Sektörü, CEMATT Yöntemi, Finansal Sağlamlık
Jel Sınıflandırması : G20, G32, G33
Dimitrie Cantemir between Sword and Pencil Wielder
Authors: Ifrim Ion
Published: December 2023

In this article, we reveal the work and personality of Dimitrie Cantemir between sword and pen, 350 years since the birth of the great scholar of Moldova, ruler of Moldova, and 300 years since his death. To celebrate the event of the Romanian scholar, the Romanian state declared this year, the Year of Dimitrie Cantemir, an event in the attention of world science. This created the opportunity to respond, through a broad presentation of the work and personality of Dimitrie Cantemir, to the deep interest not only of the Romanian people for one of the most renowned figures of national history but also to the many desires from abroad to know his scientific merits.

Of course, monographic works on the life and activity of personalities of Moldavia and the Romanian Country have been written on numerous other occasions, but since the time of Dimitrie Cantemir the seeds of a new and modern historiographical phenomenon have appeared, going beyond the biographical area of ruling families and approaching histories with a more general character. Author of numerous works, diversified thematically, among which we mention the Description of Moldavia, Dimitrie Cantemir established himself as a European scientific personality through his work, Geschichte des Wachsthums und des Sirkens des osmanischen Reiches. As has been noted, "The history of this kingdom written by him is divided into two periods, the first of its rise until 1672; the second, of its decline, from that date until 1711". In this work, the author highlights the end of the Ottoman victories and the beginning of the decline of the Ottoman Empire, through the loss of "fearful battles... and the power of the Ottomans greatly weakened by the loss of many kingdoms and countries, by the destruction of whole armies, and by internal rebellions and emperors" With this text, Dimitrie Cantemir opened the discussion of the Oriental question. Dimitrie Cantemir proved to be a keen observer and erudite commentator on practices embedded in our material and spiritual culture.
National and European Mobility in the Business Environment
Authors: Turnea Sabina
Published: December 2023

Romania has the highest percentage of active population that works in another European member state. This fact appeared in time, by mixing migration and mobility. If mobility refers to employees, migration refers to people. These two terms are not interchangeable. Mobility in employment on the territory of the European Union brings different approaches in countries, in terms of salaries and skills used. The main scope of this paper is to present some relevant national and European statistics related to mobility/ migration, and to set up some advantages and disadvantages that in the future could bring new research prospects. In order to fulfill this purpose, in this paper was made a brief synthesis regarding the literature review and a descriptive statistic analysis, using data from the Eurostat website. Data was extracted for Romania and European Union, in terms of number of emigrants and vacant jobs, for the period 2006-2019. According to aur analysis, the advantages of the mobilities are especially for the employers to whom the mobilities are carried out, but appear for the employees as well. Fresh and motivated workforce, over qualified employees and increased productivity – represent advantages in this sense. The disadvantages at the international level are: new costs for the employers for which mobilities are carried out, "brain drain" and disparities between macro-regions among the EU space. Future research prospects regarding mobility in the national and european context could be, as it follows: disparities in european space throug mobilities, the over qualified employees and mobility, the “brain drain” syndrome.
Kronik yüzeyel femoral arter tıkanıklığında retrograd rekanalizasyon: Birincil strateji olarak güvenli ve etkili mi?
Authors: BUDAK Ali Baran , GÜNERTEM Eren , TÜMER Naim Boran , ÖZIŞIK Kanat , GÜNAYDIN Serdar
Published: December 2023

Amaç: Periferik arter hastalığı (PAH), dünya çapında koroner arter hastalığı ve serebrovasküler olaylardan sonra en sık görülen mortalite ve morbidite nedenlerinden biridir. Kronik tıkalı yüzeyel femoral arter (SFA)’in endovasküler tedavisi (EVT) genellikle antegrad yaklaşımla yönetilir. Retrograd popliteal erişim (RPA), antegrad girişimin başarısız olduğu veya birincil seçenek olarak tercih edildiği durumlarda değerli bir seçenektir. Birinci basamak strateji olarak yüzüstü pozisyonda RPA'nın seçildiği ve rekanalizasyon için perkütanöz kasıtlı ekstralüminal anjiyoplasti (PIER) tekniğinin kullanıldığı hastaları, ileriye doğru girişimin başarısız olduğu ve sırtüstü pozisyonda RPA'nın kullanıldığı hastaları karşılaştırmayı amaçlıyoruz. 15 aylık takip ile rekanalizasyon için çift yönlü “randevous” tekniği kullanıldı.

Gereç ve yöntemler: Şubat 2017 ile Nisan 2019 arasında ardışık EVT'leri retrospektif olarak inceledik ve SFA lezyonlarının CTO'sunun rekanalizasyonu için RPA'nın kullanıldığı tüm EVT'leri seçtik. Çalışma, hastaları Grup 1 (n=24) olarak iki gruba ayırdı: Birinci basamak strateji olarak yüzüstü pozisyonda RPA'nın seçildiği ve rekanalizasyon için PIER tekniğinin kullanıldığı hastalar (6F Sheat ile) ve Grup 2 (n= 22): Antegrad girişimin başarısız olduğu ve endolüminal rekanalizasyon ile sırtüstü pozisyonda RPA'nın olduğu veya lezyonu geçerken telin başarısız olduğu hastalar, rekanalizasyon için çift yönlü “çift balon (randevu)” tekniği kullanıldı (Kılıfsız).

Bulgular: Teknik başarı oranı %100 oldu. RCC ve ABI her iki grupta da işlem sonrası anlamlı düzeyde iyileşti. Grup 1'de daha fazla hastaya primer stent gerekti (%70,8 vs. %45,4; p0,05). 1 yıllık uzuv kurtarma oranı her iki grup için de 100 ± 0 idi. Grup 2'de primer açıklık oranları grup 1'e göre daha yüksekti ancak bu fark ancak 6. ayda anlamlı hale geldi (grup 1'de sırasıyla %95,8, %87,5, %79,1'e karşı grup 2'de sırasıyla %100, %95,4, %81,8); p
Einleitung
Authors: Jesenšek Vida
Published: December 2023

.
151 Filologija med pragmatizmom in humanizmom
Authors: Kos Dejan
Published: December 2023

Der Aufsatz problematisiert den Status und die Perspektiven der philologischen Studien. Er geht von der Annahme aus, dass die Philologien ihren Weg aus der Randexistenz nur dann finden können, wenn es ihnen gelingt, die Ausweglosigkeit jener Logik zu enthüllen, die sie zum Randphänomen erst gemacht hat – die Ausweglosigkeit des Pragmatismus. Es geht dabei freilich nicht um die Abwendung von der Praxisbezogenheit der sprach- und literaturwissenschaftlichen Forschung. Im Gegenteil. Doch die zentrale Aufgabe der Philologien soll immerhin darin bestehen, gerade mithilfe ihres Expertenwissens das Bewusstsein für den blinden Fleck des (auch eigenen) Rationalismus und Empirismus zu schärfen. Nur die konsequente Selbstreflexion, die wertvollste Eigenschaft der Sprache und der Literatur, offenbart nämlich die eigentliche Natur unseres Daseins: die Abwesenheit des eigenen Zentrums und damit die Nähe zu allem, was wir nicht sind. Erst durch sie wird offensichtlich, wie fatal unser Bemühen ist, das Nachdenken über den Ursprung unseres Nachdenkens aus der Logik der Welterschließung und -beherrschung zu verbannen. Erst sie macht deutlich, dass gerade der Ausschluss unserer unhintergehbaren Offenheit aus dem pragmatischen Problemlösungsverfahren das zentrale Problem ist, das es zu lösen gilt. Erst durch ihre Einsicht in unser Ausgeliefertsein wird fassbar, dass das Leben nur dann sinnhaft wird, wenn der Pragmatismus weder als Grundlage unserer Überzeugungen noch als zentraler Beweggrund unserer Handlungen fungiert. Und schließlich: erst die unpragmatische »humanistische« Selbstreflexion, durch die erkennbar wird, dass uns wesentlich weniger gehört, als wir in der Lage sind, uns anzueignen, verleiht uns die Möglichkeit eines langfristigen Überlebens.
Der Einsatz von Schreibstrategien beim Verfassen von argumentativen Texten. Eine empirische Untersuchung am Sprachenpaar Deutsch-Slowenisch
Authors: Mlakar Gračner Doris
Published: December 2023

Namen prispevka je raziskovati rabo pisnih strategij slovenskih študentk in študentov germanistike pri pisanju argumentativnih besedil v maternem slovenskem in tujem nemškem jeziku. Empirična raziskava se osredotoča na analizo pisnih strategij na začetku (prvi letnik) in na koncu (četrti letnik) študija. Določene so skupne značilnosti in razlike v razvoju te vrste pisnih strategij v maternem in tujem jeziku; rekonstruirane in opisane so pisne strategije za vse delne procese pisanja (načrtovanje, strategije realizacije in strategije pregleda/poprave).
Deutsche Modalpartikeln und modalpartikelartige Lexeme im Slowenischen
Authors: Petrič Teodor
Published: December 2023

Nemški naklonski členki (MP) so jezikovno svojstvena kazalna sredstva, ki vzpostavljajo povratno povezavo s podano (vendar pogosto neizraženo) pomensko podstavo stavka ali govornim dejanjem, imajo pa zgodovinsko pogojena svojstvena pomenska obeležja in oblikoskladenjske lastnosti, s katerimi jih lahko razlikujemo od (pomensko različnih) enakozvočnic v drugih besednih vrstah. Z nemškim MP označujemo poved kot odzivno potezo popolno izražene ali le predpostavljene pogovorne sekvence. Nemške MP smo primerjali s slovenskimi nepregibnimi besedami, ki sicer imajo različne oblikoskladenjske lastnosti in enakozvočnice v drugih besednih vrstah, vendar kljub temu isto osnovno kazalno funkcijo kot nemški MP in presek pomenskih obeležij, skupnih z nemškimi MP. Funkcijska analiza se opira na besedilne odlomke iz slovenskega jezikovnega gradiva Gigafida in avtorjeve prevode le-teh v nemščino. Zaradi prostorskih omejitev je avtor podrobneje analiziral le nekaj slovenskih naklonsko rabljenih členkov (saj, mar, le, kar, mirno) in njihove značilne nemške ustreznike (ja, etwa, nur, bloß, ruhig) v različnih stavčnih tipih.