bluuebunny/crossref_metadata_2025 huggingface dataset:
ANALYSIS OF INDUSTRIAL-CAUSE OF MORBIDITY IN CONFECTIONERY FACTORY STAFF
Authors:   Department of Hygiene and Ecology of the Avicenna TSMU, Ibragimov Inomdzhon , Babaev Abdunaim ,   Department of Hygiene and Ecology of the Avicenna TSMU, Yusupov Zarif ,   Department of Implantology of the Scientific Clinical Institute of Dentistry and Maxillofacial Surgery
Published: December 2018

Objective: Assessment of the dependence of morbidity with temporal disability (MTD) on the influence of unfavourable factors of the industrial environment of workers in a confectionery factory. Methods: The data from the sick lists for the analysis of the MTD were used over the period of three years from 345 workers in the main workshops of the “Shirin” confectionery factory. In the elaboration were taken the sick lists of workers who worked for at least 1 year in the caramel (115), confectionery-chocolate (120) and biscuit (110) shops. A total of 2,120 hospital sheets were analyzed. The average indices of the MTD, the Student's criteria, and the coefficients of the pair correlation were calculated. Results: The number of incapacity for work in the caramel, candy-chocolate and biscuit shops for three years was 123.8±12.8; 118.3±12.5 and 122.6±13.2 respectively. The number of days of incapacity for work in the first workshop is 1493.5±25.7, the second workshop – 1165.7±23.9, the third shop – 1384.2±25.1 days per 100 workers, while the duration of one case was 12.06±1.0; 9.85±1.1 and 11.29±1.0 days, respectively. The lowest indices were observed in candy-chocolate, the highest in the caramel workshop. According to the grading scale of E.L. Notkin (1979), the indicators in cases and days in all three shops correspond to a 'high' level. There was statistically significant dynamic growth in MTD, depending on the age and length of service among workers in all shops. An analysis of the structure of morbidity showed that respiratory diseases (acute viral infections of upper respiratory tract, nasopharyngitis, tracheitis, bronchitis, pneumonia) occupy the largest proportion; second place – diseases of the cardiovascular system (hypertension, CHD). In the third place, the employees of the caramel and candy-chocolate shops had diseases of the digestive system, and in the workers of the biscuit shop – diseases of the musculoskeletal system. The relationship between MTD and unfavourable factors of the working environment are proved with the coefficients of the pair correlation. Conclusion: The indicators of MTD in confectionery production staff, in all three workshops, are estimated at a high level. These indicators depend on the degree of the activity of harmful production factors and standing, which dictates the need to develop recommendations, funds for improving working conditions and improving the health of workers in confectionery factories. Keywords: Occupational hygiene, morbidity with temporal disability, factor of production.
THE DISEASE INCIDENCE ANALYSIS OF THE SCABIES IN TAJIKISTAN
Authors:   Department of Dermatovenereology, Avicenna TSMU, Abdieva Dilbar , Ustobaeva Takhmina ,   Local Dermatovenereological Dispensary, Dushanbe, Tajikistan, Valieva Mukhabbat ,   Department of Dermatovenereology, Avicenna TSMU, Dyrda Nina ,   Department of Dermatovenereology, Avicenna TSMU
Published: December 2018

Objective: The study of the dynamics of the disease incidence of scabies in the Republic of Tajikistan and its administrative regions for 1991- 2014. Methods: According to the medical clearing-house of the Ministry of Health and Social Development of the Republic of Tajikistan, carried out the study of the intensive indices (II) of the disease incidence of scabies in the Republic of Tajikistan and its administrative regions for 1991-2014. Results: There are five different periods in the republic: the rise (1991-1996), the peak (1997), the sharp (1998) and slow (1999-2003) reduction, and stabilization (2004-2014). A comparative analysis of II the disease incidence of scabies was carried out in the administrative regions of the Republic of Tajikistan. Above the Republican II, the disease incidence of scabies was in Dushanbe and in regions of republican subordination, much lower in the regions of the Republic. A sharp increase in the disease incidence of scabies was first reacted in 1996 to Dushanbe (467.9). In 1997, peaks were registered in the whole country (463.6), Gorno-Badakhshan Autonomous Region (93.6), Khatlon Region (275.4) and Sughd Region (58.4). Later all this process came in 1998 in the Regions of the Republican Subordination (308.7). Conclusion: The disease incidence of scabies in Dushanbe at 19 years was higher than the Republican one and only at the peak of the disease incidence rate in the Republic (1997) is lower. II morbidity scabies in the Gorno-Badakhshan Autonomous Region, Khatlon and Sughd regions in almost all cases. Only in 2004 (in 1.7 times) and in 2004 (in 2 times) II of the disease incidence of scabies in the Gorno-Badakhshan Autonomous Region was higher than in the Republic. Over a 23-year period, the disease incidence of scabies in Tajikistan decreased in 5 times (14.9 against 73.9). A similar situation was registered in Sughd region – 4.6 times (5.9 against 27.3) and districts of Republican Subordination – 3.9 times (28.3 against 109.7). The highest rate of decline in morbidity was registered in the Gorno-Badakhshan Autonomous Region in 20.9 times (2.8 against 58.8), the lowest in the Khatlon region – 1.9 times (13.6 against 25.8). In Dushanbe, the disease incidence fell to 12.1 times (18.5 against 224.2). The obtained data are evidence of weak anti-epidemic measures in the foci of scabies. Keywords: Scabies, disease incidence, intensive indices, rates of decline and growth rates.
FEATURES OF REMODELLING OF THE LEFT VENTRICULAR MYOCARDIUM IN PATIENTS WITH ARTERIAL HYPERTENSION OF ELDERLY AGE WITH COMORBID DEPRESSION
Authors:   Department of Internal Diseases № 2 of Avicenna TSMU, Khamidov Nabidzhon , Umarov Ahmed ,   Department of Internal Diseases № 2 of Avicenna TSMU, Umarova Sitora ,   Department of Internal Diseases № 2 of Avicenna TSMU, Toirov Khisrav ,   Department of Internal Diseases № 2 of Avicenna TSMU
Published: December 2018

Objective: Тo examine the character of correlation and interaction of depressive disorders as well as the remodelling features of the left ventricle (LV) myocardium in elderly patients suffering from arterial hypertension (AH). Methods: 70 persons aged 60 to 74 years were examined. The main group consisted of 40 patients with AH: 22 men (57.5%) and 18 women (42.5%). The control group included 30 essentially healthy individuals, identical in gender and age. Structural changes in the myocardium were studied by echocardiography. Results: LV hypertrophy was significantly more common in hypertensive patients than in the control group (92.5% compared to 20%). Among the abnormalities of LV geometry in the main group, the leading place was occupied by concentric hypertrophy in 21 patients (52.5%), with eccentric hypertrophy was also significantly higher and was noted in 16 patients (40.0%). The LV ejection fraction in the average group exceeded 50%. However, when comparing individual data with indices of the control group, the falling tendency was noted (61.4±4.55 and 64.6±5.22, respectively). The same picture of the shortening of the anteroposterior size (ΔS%) of the LV (39.4±3.49 compared to 36.2±7.28). Significant differences occurred in the thickness of the posterior wall and interventricular septum. Conclusions: The revealed structural changes in the heart with AH, the development of LV hypertrophy, and its remodelling assists to the diastolic and then systolic dysfunction of the heart. Keywords: Arterial hypertension, depression, myocardial remodelling, elderly age.
STATE OF THE SPECIFIC COMPONENT OF IMMUNITY IN CHILDREN WITH HYPOTROPHY
Authors:   Department of Pediatric Diseases № 2 of Avicenna TSMU, Ismoilov Komildzhon , Rasulova Sitorabonu ,   Department of Pediatric Diseases № 2 of Avicenna TSMU
Published: December 2018

Objective: The study of the state of the cellular component of immunity in children with hypotrophy. Methods: The results of the study of 84 children aged 2 months to 2 years with hypotrophy, which were divided into 3 groups, depending on the mass deficit by Z-score index are presented. The state of the cellular component of the immune system was studied in all children. Results: The study of cellular immunity showed that in children of the group I of T-lymphocytes and their subpopulation (CD3, CD4, CD8, CD25, CD4, CD8, CD20, CD25, CD95 and CD16) were not significantly different from normal, but tended to reduction, especially the number of lymphocytes with CD4 immunophenotypes. In patients with moderate-to-severe hypotrophy (group II), a marked decrease in the average T-lymphocyte counts with immunological markers (CD4, CD8, CD16) was found in comparison with the similar indices of group I (p 0.001). In the group of patients with severe hypotrophy (group III), all indicators (CD4, CD8, CD16) and their subpopulations were significantly reduced in comparison with the group I (p 0.001). In comparison, the average of the T-lymphocyte counts with the CD4, CD8 and CD16 receptors in patients of the III groups correspond to indices of children with the mild and medium-weight hypotrophy with the statistically reliable difference (p 001). Conclusion: In children with hypotrophy, as the severity of the disease worsens, a secondary immunodeficiency state develops, the asynchronous decrease in the cellular component of immunity, which dictates the use of drugs in the complex treatment of immunodeficiency to this category of children. Keywords: Hypotrophy, children, Z-score, cellular immunity.
SOME CLINICAL AND IMMUNOLOGICAL ASPECTS OF FREQUENT SICK CHILDREN WITH HYPOTROPHY
Authors:   Department of Pediatric Diseases № 1, Avicenna Tajik State Medical University, Mamadzhanova Gulnora , Umarova Zarifa ,   Department of Family Medicine № 2, Avicenna Tajik State Medical University
Published: December 2018

Objective: To study some clinical and immunological aspects of frequent sick children (FSC) with hypotrophy Methods: 60 FSC with hypotrophy were observed. All children were divided according to the degree and severity of the disease: light – 20, average – 20, heavy – 20. The control group included 20 children. The age composition ranged from 2 months to 2 years. Methods of examination included: clinical observation, laboratory and immunological studies: quantification of leukocytes and lymphocytes. The number of lymphocytes and their subpopulations was determined using monoclonal antibodies to the differential antigens CD3, CD4, CD8, CD20, CD95, CD16, CD32. Results: In FSC with hypotrophy of light severity showed T-cells, and their subpopulation and Ig A, Ig M, and Ig G values tended to decrease in comparison with the control group. In most cases, they had uncomplicated respiratory infections, and there were no statistically reliable deviations. In FSC with hypotrophy of average severity, there was a noticeable and reliable decrease in both cellular and humoral immunity. The indices in patients with heavy severity of disease in comparison with those, in patient’s groups I and II differed even with a higher significant difference. The effectiveness of immunomodulatory therapy has been noted. Conclusion: Immunomodulatory therapy in combination with basic therapy led to a significant increase in the indices of cellular and humoral immunity in dynamics. The evidence of this was a significant decrease in intercurrent diseases in FSC with hypotrophy. Keywords: Frequent sick children, hypotrophy, cellular and humoral immunity, complex treatment.
MODERN STATE OF THE PROBLEM OF TREATMENT OF PATIENTS WITH HYPOSPADIAS
Authors:   Department of Surgical Diseases № 2, Avicenna Tajik State Medical University, Kholov Sharafdzhon , Kurbanov Ubaidullo ,   Khatlon State Medical University, Davlatov Abdumalik ,   Department of Reconstructive and Plastic Microsurgery, Republican Scientific Center for Cardiovascular Surgery, Dzhanobilova Sitora ,   Department of Reconstructive and Plastic Microsurgery, Republican Scientific Center for Cardiovascular Surgery, Saidov Iskandar ,   Department of Surgical Diseases № 2, Avicenna Tajik State Medical University
Published: December 2018

The article presents data on modern literature on the prevalence, aetiology, diagnosis, classification and treatment of patients with various forms of hypospadias. Different management approaches, as well as some contestation about the arrangement of diagnosis patients with hypospadias were analyzed. As the having data shows the surgical treatment of hypospadias does not lead to the restoration of the aesthetic and functional component of the process, with the result that optimization of surgical treatment in contemporary conditions it remains the actual task of reconstructive-plastic surgery and urology
THE INFLUENCE OF TECHNOGENIC FACTORS OF THE PRODUCTION AND ENVIRONMENT ON THE PREVALENCE AND STRUCTURE OF THE PATHOLOGY OF THE DENTISTRY SYSTEM
Authors:   Department of Hygiene and Ecology, Avicenna TSMU, Yusupov Zarif , Babaev Abdunaim ,   Department of Hygiene and Ecology, Avicenna TSMU, Ashurov Gayur ,   Department of Therapeutic Dentistry of the Institute of Postgraduate Education in Healthcare
Published: December 2018

In the presented review of the literature, the questions of the influence of various factors of the production and the environment on the prevalence and structure of diseases of the dentition system are examined. Based on the analysis of literary data, the authors summarize that various technogenic factors negatively affected to the dental status of workers with harmful working conditions, as well as the population living in unfavourable environmental conditions. This causes a more pronounced intensity of caries, non-carious lesions of the teeth, diseases of the periodontal and tunica mucosa of a mouth. The results of studies indicate that there is a gradual increase in the prevalence of dental and periodontal diseases as the length of service increases.
THE RESULTS OF COMPLEX TREATMENT OF HELICOBACTER PYLORI ASSOCIATED FORMS OF STOMACH AND DUODENAL ULCER DISEASE IN THE POPULATION OF MAZARI SHARIF PROVINCE OF THE ISLAMIC REPUBLIC OF AFGHANISTAN
Authors:   Senai University, Mazari Sharif, Islamic Republic of Afghanistan, RAMAZON KH. KH , SHOKIROV YU.A. ,   Department of Internal Diseases № 1, Avicenna Tajik State Medical, Dushanbe, Tajikistan, JALILOV S.S. ,   Department of Internal Diseases № 1, Avicenna Tajik State Medical, Dushanbe, Tajikistan
Published: December 2018

Objective: To study the effectiveness of eradication therapy in patients with H. pylori-associated forms of stomach and duodenal ulcer disease. Methods: In 88 patients with Helicobacter-associated forms of stomach and duodenal ulcer disease on the basis of clinical, endoscopic, bacteriological methods with PCR formulation, the effectiveness of the Maastricht scheme of triple therapy was studied. The patients were divided by age, gender and the nature of ulcerative lesions. The effectiveness of treatment was assessed by the following criteria: abating of clinical symptoms, cicatrization of ulcerative defect and degree of eradication of H. pylori. Results: The obtained data showed that complete scarring of «single» stomach ulcers reached 100.0%, and eradication in 80.0% of patients. With «multiple» ulcers scarring was observed in 60.0%, and eradication – in 80.0% of cases. With «round» and «peptic» stomach ulcers, scarring took place in 16.7%, and eradication occurred in 33.3% of patients, while in the duodenum, these indicators were relatively higher – 40.0% and 60.0% respectively. In the general population of the examined patients with gastric ulcer, scarring reached 60.0%, eradication – up to 71.8%; the best indicators were noted for peptic ulcer disease – 83.9% and 87.5%, respectively. Conclusion: Three-component eradication therapy Helicobacter-associated forms of stomach and duodenal ulcer disease with the prescription of Clarithromycin, Amoxicillin in combination with Omeprazole is quite highly effective. The results of treatment are definitely dependent on the location and nature of the ulcerative lesion, H. pylori strains and the patient’s age. Keywords: Stomach ulcer, duodenal ulcer, Helicobacter-associated ulcerative lesions, scarring, eradication.
OPTIMIZATION OF SURGICAL TREATMENT OF POST-BURNING TIGHTENING SCARS OF FRONT SURFACE OF THE NECK AND THE CHEST
Authors:   Khatlon State Medical University, Kurbanov Ubaidullo , Saidov Iskandar ,   Avicenna Tajik State Medical University, Davlatov Abdumalik ,   Department of Reconstructive and Plastic Microsurgery of the Republican Scientific Center for Cardiovascular Surgery, Dzhanobilova Sitora ,   Department of Reconstructive and Plastic Microsurgery of the Republican Scientific Center for Cardiovascular Surgery
Published: December 2018

Objective: Evaluation the results of surgical treatment of post-burn cicatricial deformities and contractures of the front surface of the neck and thorax.Methods: The results of surgical treatment of 80 patients with post-burn scars on the anterior surface of the neck and thorax analyzed. The age of the patients ranged from four to 40 years and averaged 19.2±6.5 years. There were 13 men (16.3%) and 67 women (83.7%). Patients arrived at the time from 1 year to 36 years after receiving the burn. Four clinical groups identified: isolated constrictive scars of the anterior surface of the neck – 38 (47.5%) patients; extensive contracting scars of the anterior thoracic surface – 16 (20%); combined constrictive scars of the anterior surface of the neck and thorax with deformity of the mammary gland – 8 (10.0%), and post-burn scars of the anterior thoracic surface, extending to the anterior surface of the shoulder joint – 18 (22.5%) patients. Surgical tactics depended on the severity and extent of the scarring process.Results: In the immediate postoperative period, 96.3% (77 cases) in patients noted primary healing implantation grafts and flaps engraftment. Complications noted in 3 (3.7%) cases in the form of marginal necrosis of the skin (2) and venous thrombosis of the vascular pedicle of the flap with necrosis of the graft. Long-term results studied in 75 (93.7%) patients in the period from 6 months to 16 years after the operation. Good results were noted in 67 (89.3%) patients, satisfactory – in 5 (6.6%), unsatisfactory – in 3 (4%) patients.Conclusion: Post-burn cicatricial deformities of the anterior surface of the neck and thorax are a complex and multifaceted problem in reconstructive and plastic surgery; in order to obtain optimal long-term results, the choice of the method of surgical treatment should be differentiated.Keywords: Burn, scars, post-burn tightening scars on neck and thorax, pedicled parascapular flap.
EFFICIENCY OF THE APPLICATION OF «STIMUL-OSS» OSTEOPLASTIC MATERIAL IN COMBINATION WITH PLATELET-RICH PLASMA FOR THE EXTRACTION OF THE RETAINED AND DYSTOPIC MANDIBULAR THIRD MOLAR
Authors:   Department of Pediatric Dentistry, Maxillofacial and Plastic Surgery, KRSU named after B.N. Yeltsin, Toktombaev Meder , Yuldashev Ilshat ,   Department of Pediatric Dentistry, Maxillofacial and Plastic Surgery, KRSU named after B.N. Yeltsin, Boronchiev Azamat ,   Department of Operative Dentistry, KRSU named after B.N. Yeltsin, Ashimov Zhanibay ,   Department of Prosthetic Dentistry, KRSU named after B.N. Yeltsin
Published: December 2018

Objective: Optimization tactics and treatment results of the difficult eruption of lower third molars on the bases of the osteoinductive materials.Methods: Depending on the chosen tactics of treatment, patients were divided into 2 groups. The first (main) group (29 patients – 51%), in which, after extraction of the lower third molar, the bone defect filled by the osteoplastic material «Stimul-OSS», and then covered by membrane-shaped platelet-rich plasma. And second (control) group (28 patients – 49%), where treatment was carried out according to traditional techniques.Results: When analyzing the dynamics of leukocyte infiltration index by 7 days of treatment, the level of leukocytes in group II decreased to 6.0±0.3×109 /l, the ESR was 9.08±4.6 mm/h, whereas in the main group during this time, the leukocyte and ESR values were 5.60±0.3×109 /l and 9.09±2.89 mm/h, which indicated the normalization of the general condition of the patients. The results of densitometry in the main group in 12 months after tooth extraction corresponding to the norm – 1631.8±14.9 units. Analysis of the acidic-alkaline state of the alveolar socket of the removed tooth in the observation dynamics showed that a more positive picture noted in the main group. Conclusion: The developed method of bone plastic surgery by the surgical treatment of retained dystopic lower third molars with the application of combination of osteoplastic material «Stimul-OSS» with platelet-rich plasma is pathogenetically grounded. This technique reduces healing time and treatment; has a medico-social and economic effectiveness of reduction of hospital stay and improved patients quality of life.Keywords: Retention, dystopia, platelet-rich plasma, Stimul-OSS, osteoplastic materials.
Authors: Trong Hoang Mai
Published: December 2018

Pollution load into Truong Giang river has been calculated by the current status and socio-economic development planning of districts along the Truong Giang river, including Duy Xuyen, Thang Binh, Tam Ky and Nui Thanh until 2030. By using the environmental rapid assessment method from development activities, the results indicate that 2017, the Truong Giang river received 20,476.92 tons of COD; 31,517.79 tons of BOD; 1,069.585 tons of NO3-+ NO2-; 1,023.65 tons of NH4+ and 203,240.50 tons of TSS from residents, industry, aquaculture, livestock farming, soil leaching and the discharge from Thu Bon and Tam Ky rivers. By 2030, the amount of waste will be increased to between 1.1 and 1.5 times. The main pollution sources are from residents, livestock farming and two-river discharge. Therefore, wastewater treatment from these sources is essential to minimize the amount of waste entering the Truong Giang river.
Model of Estimating the Aquaculture Carrying Capacity for Shallow-Water Tidal Embayments. Model application to Ben Beo bay, Cat Ba island, Hai Phong
Authors: Thi Le Ha Trinh
Published: December 2018

Abstracts: Model was developed to estimate the production carrying capacity of water bodies based on nutrient inputs from aquacultures, flushing rates and the risk of algal blooms for Shallow-Water Tidal Embayments. Model was applied to Ben Beo bay, Cat Ba island, Hai Phong.The calculations suggest that nutrient loadings from cage-culture practices in 2017 were greater than the carrying capacity of Ben Beo during low and average tidal exchange. The emission of nutrients by fish cultures in 2008 into water body was greater than the sustainable carrying capacity. The aquaculture production in Plan has not overcome Ben Beo’s carrying capacity even during low tidal exchange. However, during neap tide, carrying capacity has been able to overcome

Keyword: Carrying capacity, nutrient, aquacultures
Estimating the Sea Current Field and Assessing the Potential for Exploiting Electricity from the Sea Current in the Estuary of the Mekong River
Authors: Thi Vui Vu
Published: December 2018

Abstract: Exploiting renewable energy from the sea is a topic of great interest in recent years in Vietnam. Many coastal areas of our country have been surveyed to assess the potential of marine energy exploitation. However, there have been no studies detailing the potential of exploiting the sea current energy in the Mekong River mouth. This study aims to estimate the potential of marine power generation for the Mekong River mouth by calculating the ocean current flow using the Regional Ocean Modeling System (ROMS). It is estimated following one of the marine electricity generation equipment is being studied in Vietnam.The results show that the potential for power exploitation in the Mekong River mouth is positive, with total capacity reaching over 209 MWh at the river mouth, above 116 MWh in Con Dao in January and above 55 MWh in both locations in July in 2018.

Key words: ocean currents,recycled energy, Mekong estuary, South East sea, ROMS
The Relationship Between Cloud Cover and Outgoing Longwave Radiation in the Southern of Vietnam
Authors: Thi Thu Huong Chu , Thi Hop Bui , Dinh Linh Tran , Thanh Hang Vu
Published: December 2018

Abstract: Based on the data that has the resolution is 1,00×1,00of the Outgoing Longwave Radiation (OLR) and the cloud cover from NCEP/NCAR in the 1981 – 2012 period, the relationship between the cloud cover and the OLR in the Southern of Vietnam wasinvestigated when analyze and compare the spatial distribution, temporal evolution and their correlation. The results show that the characteristics of the spatial distribution and the year cycle of cloud cover and OLR are inversely correlated. The region or time that the cloud cover is great, the OLR is small and vice versa. In the Southern of Vietnam, the OLR value isgreatest(or smallest) in the dry (or rainy) season and in the El-Nino (La-Nina) years. In addition, during the 1981-2012period, the OLR in this region shows a downward trend about 3.6 W/m2/decade, while the cloud cover tends to increase by 0.2%/decade.

Keywords: Cloud cover, Outgoing Longwave Radiation, the Southern of Vietnam.
Variations of Summer Monsoon During Tropical Cyclone Activity in the Vietnam’s East Sea
Authors: Dinh Linh Tran , Thi Thu Huong Chu , Thi Kim Ngan Tran
Published: December 2018

Abstract: In order to investigate the variation of Summer Monsoon (SM) during Tropical Cyclone(TC) acitivityin the Vietnam’s East Sea (VES), we have used the ERA Interim reanalysis data to evaluate the variant of SM intensityin two areas at three levels (1000mb, 850mb and 700mb). The first area(0 - 100N; 105-1100E) was used to examine the change of wind from Australian High and the second area(5 - 150N; 90 - 1050E)was used to analyze the change of wind from Mascarene High. These variations are investigated towards two characteristics: (1) Anomaly of wind compared with mean value and (2) Appearance frequency of wind in each value range. The resultsshowthat SM intensityduring TC activity in the VESis less dependent on the time of year. SMI is stronger from 30% up to 85% of the mean values. In addition, during TC activity in the VES, frequency of SMI gets the maximum valueat the range of VTB - 1,5VTB or 1,5VTB - 2VTB with the total of frequency from 55% to 75%.

Key words: Variations of Summer Monsoon; Tropical Cycloneactivity in the Vietnam’s East Sea.
The Establishing the Genotyping Method for rs1057910 on CYP2C9 and rs9923231; rs9934438 on VKORC1 in blood samples of Cardiac Valve Replacement Patients treated with acenocoumarol
Authors: Thi Le Hang Do
Published: December 2018

Acenocoumarol is widely prescribed for patients with risk of thromboembolism in Vietnam. A lot of study revealed that genetic polymorphisms of CYP2C9 and VKORC1 genes are the strongest genetic factors that have a high-impact upon the response of acenocoumarol. Therefore, in this study, we established the genotyping method of CYP2C9 and VKORC1 on Vietnamese cardiac valve replacement patients treated with acenocoumarol. Main method included DNA extraction from peripheral blood samples, polymerase chain reaction (PCR) for amplification of target genes, identifying the genotype by Sanger sequencing and restriction fragment length polymorphism PCR (PCR-RFLP). The results showed that we successfully established the optimal condition to amplify targeted polymorphism as rs1057910 of CYP2C9 gene and rs9923231, rs9934438 of VKORC1 gene.
Nghiên cứu phát triển sản phẩm thực phẩm chức năng và mỹ phẩm trắng da chống nám từ nguồn nguyên liệu thiên nhiên Việt Nam
Authors: Vu Duc Loi
Published: December 2018

Qua tổng hợp dữ liệu và sàng lọc insilico đề tài đã xác định được 21 hợp chất tiềm năng ức chế enzym tyrosinase. Đề tài xác định dược liệu có chứa nhóm chất có tiềm năng ức chế enzym tyrosinase và được dùng làm trắng da theo kinh nghiệm dân gian là lá dâu tằm. Từ lá dâu tằm, đề tài đã chiết phân lập được các phân đoạn dịch chiết và 11 hợp chất nhóm flavonoid, terpenoid:Acid 3,4-dihydroxybenzoic, Acid ellagic, Acid gallic, Kaempferol 3-O-β-D-glucopyranosid, Quercetin 3-O-α-L-rhamnopyranosid, isofraxidin-7-O- β -D-glucopyranosid, (±)-3,5,6,7,8,4’-hexahydroxyflavan, Kaempferol-3,7-di-O-α-L-rhamnopyranosid, 7,4’-dihydroxy-5,3’-dimethoxyflavon, (S)-5,5’,7-trihydroxy-2’,4’-dimethoxy-6-methylflavanon.Đề tài đã đánh giá độc tính cấp, tác dụng làm trắng da trên invitro và invivo với phân đoạn dịch chiết và hợp chất phân lập được. Kết quả cho thấy phân đoạn dịch chiết có độ an toàn cao, phân đoạn dịch chiết và hợp chất phân lập được có tác dụng làm trắng da tốt. Đề tài đã xây dựng công thức sản phẩm và bào chế sản phẩm dạng viên nang cứng và dạng kem bôi ngoài da, sau đó đánh giá tác dụng làm trắng da và tính kích ứng da của sản phẩm. Kết quả cho thấy 2 sản phẩm có độ an toàn cao, không gây kích ứng và có tác dụng làm trắng da tốt. Với kết quả này đề tài đã phối hợp với các công ty để đăng ký sản phẩm thực phẩm chức năng viên nang trắng da Morus và mỹ phẩm dạng kem MELAGENN.
CƠ CHẾ QUẢN TRỊ ĐẠI HỌC TỰ CHỦ VÀ YÊU CẤU HOÀN THIỆN PHÁP LUẬT TỰ CHỦ ĐẠI HỌC Ở VIỆT NAM
Authors: Đỗ Đức Minh , Lương Thị Bằng
Published: December 2018

Bài viết làm rõ những vấn đề cơ bản về cơ chế quản trị đại học tự chủ, khái quát tiến trình thể chế hóa chủ trương tự chủ đại học và triển khai thực hiện tự chủ đại học trong thời gian qua, phân tích những hạn chế, bất cập của pháp luật và làm rõ nhu cầu hoàn thiện pháp luật về tự chủ đại học, đáp ứng yêu cầu đổi mới căn bản, toàn diện giáo dục đại học hiện nay.
PENGANIAYAAN TERHADAP NARAPIDANA PELAKU PERKOSAAN YANG MENGALAMI LABEL NEGATIF DI LEMBAGA PEMASYARAKATAN (STUDI DI LEMBAGA PEMASYARAKATAN WIROGUNAN YOGYAKARTA)
Authors: Martha Aroma Elmina , Khoirunnas Chandra
Published: December 2018

This article is a case study on the legal issues surrounding beatings and torture suffered by rape offenders incarcerated in the Wirogunan Prison, Yogyyakarta.  Purpose of this research is to identify profile of perpetrator and determinate what factors are behind this deviant behaviour.  This research uses a criminological method or approach. Data has been obtained from direct observation, expert interviews and literature review.  One of the important findings is that beatings and torture of rape offenders are justified by the general inmates on the basis of negative labelling given toward the offender and his crime.
INKONSISTENSI PENERAPAN PRINSIP INDEPENDENSI KEKUASAAN KEHAKIMAN DALAM PELAKSANAAN SELEKSI CALON HAKIM
Authors: Azhar Ikhsan
Published: December 2018

The general public in 2017 hotly debated the implemented selection process of Judges. The focus is on the issue of government involvement in the selection process which potentially jeopardize the judiciary’s independence.  In discussing this particular issue, the author uses a juridical normative or dogmatic approach and other data is collected by the use of library research . In addition, the author also compares the existing policy and rules/regulation concerning judge selection from different government’ era (the Old & New Order). A number of conclusions can be drawn from this comparison, i.e. that during the Old dan New Order Government, the judiciary was never considered independent. The government on a regular basis intervene in the selection process, appointment and placement of judges and have a strong say in their professional carrer path.  In contrast, only after the fall of the New Order Government, did the Judiciary enjoy independence which is guaranteed by virtue of Law 35/1999 and the 1945 Constitution (amended version).  Unfortunately though the Supreme Court decide to bring back in the government in the selection process and in doing that jeopardize the judicary’s independence.
KEPATUHAN HUKUM IBU TERHADAP KETENTUAN PIDANA TERKAIT PERBUATAN YANG MENGAKIBATKAN PENDERITAAN PSIKIS ANAK
Authors: Windayani Tisa
Published: December 2018

Art 80 and Art 76C  of Law No. 35/2014 purports to protect children from domestic violence (including most importantly those committed by the mother of the child).  This article using empirical juridical purports to analyze what factors are influential in determining compliance.  Primary data is collected using purposive sampling technique and subsequently is analyzed qualitatively.  The main result of the research is that avoidance of penal sanction is not a significant role in determining legal compliance.  More significant or influential are factors such as the extent or level of understanding the rule’s purpose or values behind the existing rule (prohibiting domestic violence), the need to maintain good relationship with the child; identification of the mother with certain groups in society and personal values.
KONTROVERSI STRICT LIABILITY DALAM HUKUM PERLINDUNGAN KONSUMEN
Authors: Gunawan Johannes
Published: December 2018

This paper, using a comparative law method, discusses the controversy concerning the meaning and interpretation of strict liability as found in the Indonesian Consumer Protection Law.  How in Indonesia this concept is understood will be compared to how the same concept (strict liability) is developed within the Dutch civil law system and the common law system (especially in the United Kingdom(UK)and United State of America (USA)).  A brief description of the meaning and development of the concept in Indonesia will be given, including the historical trajectory of the concept within those different systems and the important case laws in the Netherlands, UK and USA.  All this will provide a background for the author to discuss and criticize the strict liability concept as found regulated in Law No. 8 of 199 on Consumer Protection.
IDENTIFICATION OF A PERSON BY THE DNA OF THE PULP OF THE TOOTH
Authors: Syrak S. V. , Gatilo I. A. , Mazevskaya Yu. S.
Published: December 2018

Aim. The study was designed for conducting a molecular genetic analysis of DNA of the tooth pulp and establishing the genetic relationship of the child and the parent.

Materials and methods. The tooth number 16 of the claimed father was provided for the DNA extraction. Saliva samples and DNA preparations of the prospective daughter were obtained for the study. In the course of the research, the M-sorbbone reagent kit was used to isolate DNA from the bone powder.

Results. The conducted studies have shown that the DNA preparations isolated from a tooth and the N sample of saliva have the following genotypic allelic combinations. It was established that for each of the studied STP systems in the genome of the claimed father an allele is found, which formally coincides with the allele of conditionally paternal (nonmaternal) origin in the child’s genome.

Conclusion. As shown by the results of the study, the only carrier of DNA in a forensic medical molecular genetic examination, in this case, was a tooth, namely, pulp, which was protected by the durable tissues – dentin and enamel. The uniqueness of this case lies in the fact that it is the pulp that is the only tissue that retains the genetic information making it possible to state the high probability of the claimed relationship of the father and the child.
ESTIMATION OF CLINICAL AND PHARMACOECONOMIC EFFICIENCY OF PROTON PUMP INHIBITORS DURING GASTROESOPHAGEAL REFLUX DISEASE (GERD) TREATMENT
Authors: Shabanova N. E. , Korochanskaya N. V. , Ponomareva A. I.
Published: December 2018

Aim. The study was conducted to estimate the clinical and pharmacoeconomic efficiency of proton pump inhibitors (PPIs) omeprazole and esomeprazole when GERD patients undergo a course of medical treatment.

Materials and methods. 25 GERD patients with a history of the disease for more than 5 years were under observation in Krasnodar regional clinical hospital № 2 from 2017 till 2018. All the patients have been thoroughly examined. Conservative therapy included the «gold standard» of proton pump inhibitors. Evaluation of the efficiency included the number of disease relapses in the period of dynamic observation and the calculation of the cost-effectiveness ratio.

Results. When patients were taking esomeprazole, the relapses of the GERD disease were rare. The cost-effectiveness ratio was lower.

Conclusion. The use of esomeprazole during the treatment of GERD patients has lower economic expenditures. The relapses of the disease are also less frequent.
THREE-DIMENSIONAL ECHOGRAPHIC EVALUATION OF CHORION VASCULARIZATION IN 1st TRIMESTER OF GESTATION IN WOMEN WITN THROMBOFILIA
Authors: Asriyants M. A. , Astafieva O. V. , Shcherbina V. G.
Published: December 2018

Aim.Determine the threshold values of quantitative indices of chorionic volume flow in pregnant women with thrombophilia in the first trimester of pregnancy for the prediction of miscarriage and evaluate the effectiveness of anticoagulant therapy.

Materials and methods.Ultrasound examination of the embryo and extraembryonic structures with volume reconstruction of the chorion and determination of quantitative indices using VOCAL program − vascularization index (VI), flow index (FI), vascularization flow index (VFI) in women with thrombophilia from 7th to 10th of the week of gestation.

Results.The analysis of the quantitative parameters VI, FI and VFI in pregnant women in the first trimester showed high reliability (p<0.001) in the value of VI and VFI in pregnant women with thrombophilia without treatment and in the pregnant control group, as well as in pregnant women with thrombophilia before and after anticoagulant therapy. Among the most informative parameters for assessing the chorion vascularization in predicting miscarriage VFI≤7,80 has highest value for negative outcome. Index VI due to the very high specificity (SP = 82.6%) better more informative for predicting a favorable outcome.

Conclusion.The use of the proposed method allows us to identify a risk group for predicting miscarriage in the first trimester in pregnant women with thrombophilia and promptly prescribe anticoagulant therapy and evaluate its efficiency.
SOMATOTYPOLOGICAL CHARACTERISTIC OF THE REPRESENTATIVES OF DIFFERENT AGE PERIODS AND ITS IMPORTANCE IN SPORTS ORIENTATION
Authors: Bakhareva N. S. , Baibakov S. E. , Yulmukhametov D. R. , Gordeeva E. K. , Bakhareva A. A.
Published: December 2018

Aim. The study was designed for the theoretical analysis of the somatotypological characteristics of people of the second childhood, adolescent, youthful and mature age periods and their importance for sports orientation.

Materials and methods.In course of the theoretical analysis, the search was performed in Scopus, eLIBRARY and PubMed databases using the keywords “somatotype”, “morphometry”, “somatometry”.

Results. The presented materials are considered from the ecological, geographical, ethnical and territorial perspectives that have a significant impact on the constitutional heterogeneity of the population. The features of the somatotypological characteristics of boys and girls participating in various sports are being specified. Concluding the analysis of the literature, it can be stated that in a number of studies, certain ratios of the main body types were observed in healthy individuals of various ethnical and territorial groups. However, upon closer acquaintance with this material, significant contradictions are revealed regarding the nature and the degree of manifestation of these shifts, and, in some cases, even mutually exclusive statements are made.

Conclusion. In view of the above, it is possible to conclude that further systematic study of these issues is needed.
THE STRUCTURE AND CLINICAL MANIFESTATIONS OF JUVENILE IDIOPATHIC ARTHRITIS IN CHILDREN IN KRASNODAR
Authors: Burlutskaya A. V. , Savelyeva N. V. , Polischuk S. V.
Published: December 2018

Aim. The research was conducted to study the structure (variants, sexual and age characteristics) and manifestations of articular syndrome in children with juvenile idiopathic arthritis in Krasnodar.

Materials and methods. There was conducted a retrospective analysis of 89 case histories in patients aged 2-15 diagnosed with juvenile idiopathic arthritis for the first time.

Results. As a result of the study, the following variants of juvenile idiopathic arthritis were diagnosed: oligoarticular – in 62 patients (69,6%), polyarticular – in 24 patients (27%) and systemic – in 3 children (3,4%). Group 1 consisted of 62 patients with oligoarticular variant, and group 2 consisted of 24 patients with polyarticular variant. In the sexual aspect, there were 1,5 times more girls than boys among all the studied children. There are also a higher number of the females within the groups. The average age of the onset of the disease in all patients with juvenile idiopathic arthritis was 8,9±0,4 years. In group 1, the average age was 9,6±0,5 years, in group 2 – 7,4±0,4 years. In children with oligoarticular variant of the disease, knee and ankle joints were more often involved in the process. In group 2, the pathological process involved both large joints and small joints of the hands and feet. Leukocytosis, accelerated erythrocyte sedimentation rate and positive results of immunological studies were more often detected among the children of the second group. On the radiographs, cartilage and bone changes were found in 9% of patients.

Conclusion. Among the patients with juvenile rheumatoid arthritis, the residents of Krasnodar, the oligoarticular variant dominates (69,7%), the polyarticular RF-negative variant is in second place (25,8%), the systemic variant is in third place (3,4%), and the polyarticular RF-positive variant is in last place (1,1%). In the sexual aspect, there were 1,5 times more girls than boys among all the patients. The onset of the joint syndrome mainly occurs in early school and puberty age. The articular syndrome was manifested mainly by the arthritis of the knee, ankle joints, and the polyarticular variant was also manifested by the arthritis of the wrist joints and small joints of the hands and feet. Among the patients, the signs of humoral activity and immune inflammation were more characteristic of the polyarticular variant. At the onset of disease, the changes of cartilaginous and bony tissues of the joints were identified by the radiography only in 9% of cases.
USING THE THROMBODYNAMICS TEST IN THE INTEGRATED PERIOPERATIVE MONITORING OF THE BLOOD COAGULATION SYSTEM IN SURGICAL PATIENTS
Authors: Vaginivan84@gmail.com; I. V. , Karipidi G. K. , Barishev A. G. , Savchenko U. P. , Bazlov S. B. , Avakimian S. V. , Popov A. U. , Kanksidi I. V.
Published: December 2018

Aim.The research was conducted to evaluate the possibilities of the "Thrombodynamics" test in the integrated monitoring of the blood coagulation system and the choice of the method of prophylaxis of thromboembolic complications in the postoperative period in surgical patients.

Materials and methods. 123 patients were operated for acute surgical pathology of abdominal organs. The "Thrombodynamics" test was used in a complex assessment of the state of the blood coagulation system. After the statistical processing by the methods of variation statistics, the results were used to predict the risk of the occurrence and changes in the volume of therapy for thromboembolic complications, taking into account the current understanding of the thrombodynamic properties of the fibrinous clot. Correction of the hemostasis system was based on "Russian Clinical Recommendations for the Diagnosis, Treatment and Prevention of Venous Thromboembolic Complications" approved by the Expert Meeting on May 20, 2015.

Results.It was found that 101 (82.1%) patients had abnormalities in the blood coagulation system after the surgery for acute abdominal cavity diseases complicated by peritonitis. We established the direct dependence of the predicted risk of thromboembolic complications on the degree of severity of secondary peritonitis. 52 (42.3%) patients needed a correction of thromboprophylactic therapy, which made it possible to exclude the occurrence of venous thromboembolic complications.

Conclusion. The use of the "Thrombodynamics" test in the complex evaluation of the qualitative characteristics of the blood coagulation system in surgical patients with a complicated course of the disease in the perioperative period makes it possible to objectively assess the risks of the thromboembolic complications and to correct a thromboprophylactic therapy to exclude the thromboembolic complications.
EVALUATION OF OXIDATIVE METABOLIC DISORDERS IN WOMEN SUFFERING FROM CHRONIC INFLAMMATORY DISEASES OF SMALL PELVIS
Authors: Egorova I. A. , Krutova V. A. , Zavgorodnyaya A. G.
Published: December 2018

Aim.The study was conducted to evaluate the intensity of oxidative disorders in women suffering from a complex course of chronic endometritis and salpingo-oophoritis.Materials and methods. The study was performed on 85 women divided into 3 groups: the control group – relatively healthy patients (n=30), the 2nd group – the patients suffering from chronic endometritis (n=29), the 3rd group – the patients suffering from a complex course of chronic endometritis and bilateral salpingo-oophoritis (n=26). The indices of chemiluminescence induced by the hydrogen peroxide were determined in the blood plasma and the mixed oral liquid. The content of products of oxidative modifications reacting to the thiobarbituric acid was determined in the erythrocyte meal and the mixed oral liquid.

Results.The evaluation of the content of the product of oxidative modifications in biomolecules as well as the level of luminal-dependent chemiluminescence induced by the hydrogen peroxide revealed the intensification of free-radical processes in blood and the mixed oral liquid of patients suffering from inflammatory diseases of small pelvis. The index of the thiobarbituric value and the maximal chemiluminescence flash increased by 60-70% in the blood of patients from the 2nd-3rd groups. The area of chemiluminescence flash of the blood plasma in patients suffering from chronic endometritis increased by 73%, while in patients suffering from a complex course of chronic endometritis and bilateral salpingo-oophoritis it was significantly higher – by 2.1 times. The increase in the value of the maximal chemiluminescence flash by 45% and the chemiluminescence area by 43% was detected in the mixed oral liquid of the patients from the 3rd group, while the increased value of only chemiluminescence area (by 42%) was revealed in patients of the 2nd group.

Conclusion.The results of the performed study revealed that the intensity of oxidative processes on the local and systemic levels in patients suffering from a complex course of chronic endometritis and double salpingo-oophoritis was significantly higher than in patients suffering from an isolated course of endometritis.