bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of Carob Fruit Extract on Spermatogenesis, Antioxidant Status, and Apoptosis in Adult Male Mice
Authors: Sadat Seyed Sadegh , Mohammadi Shabnam , Sazegar Ghasem , Fazel Alireza , Ebrahimzadeh Alireza , Ghayour Mobarhan Majid , Beheshti Farimah , Attari Seyedeh Saleheh , Tavallaei Shima
Published: October 2019

Background: Certain plants stimulate spermatogenesis and increase fertility; in contrast, some plants arrest the spermatogenesis cycle. Ceratonia siliqua is an herb plant with a strong antioxidant property. The aim of this study was to evaluate the effects of carob fruit extract on spermatogenesis, testicular apoptosis, and oxidative stress in adult male mice. Methods: Forty adult male mice were randomly divided into five groups: control, sham, and carob 1–3. The sham group was injected with normal saline and the carob 1–3 groups were injected with 200, 400, and 800 mg/kg of the carob fruit extract intraperitoneally for 14 days, respectively. At the end of the injection period, spermatogenesis, testicular apoptosis, and oxidative stress were examined. Results: The sperm parameters increased in the mice that received 200 mg/kg of carob compared to the sham group (p <0.05). There was a significant increase in the weight index of the epididymis in the carob 3 group in comparison to the sham group (p = 0.01). The number of positive tunnel cells was not statistically significant between different groups (p>0.05). The level of malondialdehyde decreased in the carob 1 and carob 3 groups, but this reduction was not statistically significant (p > 0.05). In addition, the statistical analysis showed a significant difference in the mean superoxide dismutase levels in the carob 2 and carob 3 groups in comparison to the sham group (p ≤ 0.001). The statistical analysis showed a significant increase in the mean level of the catalase enzyme in the carob 1 group in comparison to the sham (p = 0.02), and carob 2 groups (p = 0.008). Conclusion: The administration of 200 mg of the carob fruit extract for 14 days increased the testicular index as well as sperm parameters and decreased the level of oxidative stress in the testicular tissue of adult mice.
Hydroalcoholic Extract from Rhizomes of Cynodon dactylon Improve Hemodynamic and Electrocardiogram Parameters in Myocardial Infarction in Rats
Authors: Abbaszadeh Samin , Garjani Alireza , Nazemiyeh Hossein , Ayadi Sepideh , Mohajer Milani Majid , Soraya Hamid
Published: October 2019

Background: Cynodon dactylon is a herbal medicine of interest in Iranian traditional medicine, which is used in cardiovascular diseases such as atherosclerosis and heart failure. The purpose of this study was to evaluate the effects of total extract of C. dactylon rhizomes on myocardial infarction and on post myocardial infarction (MI) heart tissue injuries. Methods: Isoproterenol (100 mg/kg) was injected subcutaneously for two consecutive days for induction of MI in rats and C. dactylon extract was administered orally twice daily started before isoproterenol injection for 4 consecutive days. Results: Histopathological analysis showed a marked increase in myocardial necrosis in rats with MI (p<0.001). Treatment with C. dactylon (200 mg/kg) significantly (P<0.05) decreased myocardial necrosis. Hemodynamic variables were significantly suppressed in MI group and treatment with C. dactylon improved the hemodynamic parameters (P<0.05). Our electrocardiogram analysis demonstrated that C. dactylon with all doses increased R-Amplitude and R-R Interval (p<0.05, p<0.01) which were suppressed in MI group. Furthermore in treated groups with 100 and 200 mg/kg, P-R interval was also significantly increased in compared to MI group. Conclusion: This study demonstrated that C. dactylon can improve hemodynamic and electrocardiogram parameters in isoproterenol-induced myocardial infarction and thereby suggest that it can be used as a cardioprotective agent in myocardial infarction.
Performance of Local Composition Models to Correlate the Aqueous Solubility of Naproxen in Some Choline Based Deep Eutectic Solvents at T = (298.15-313.15) K
Authors: Mokhtarpour Masumeh , Shekaari Hemayat , Martinez Fleming , Zafarani-Moattar Mohammed Taghi
Published: October 2019

Background: To overcome low solubility of naproxen (NAP), deep eutectic solvents (DESs) based on choline chloride (ChCl) with glycerol (G) and oxalic acid (OA) as green solvents have been used up to 0.9 mole fraction of DES at T = (298.15 to 313.15) K. Methods: DESs were prepared by combination of the two components with the molar ratios: ChCl/glycerol (1:2) and ChCl/oxalic acid (1:1). The solubility of NAP in the aqueous DESs solutions was measured at different temperatures with shake flask method. Results: The solubility in these solvents increased with increasing the weight fraction of DESs, especially in ChCl/OA. The solubility data were correlated by e-NRTL, Wilson and UNIQUAC models. Also, the thermodynamic functions, Gibbs energy, enthalpy, and entropy of dissolution were obtained. Conclusion: Oxalic acid based DES exhibits higher solubility than glycerol based DES. The thermodynamic models were successfully used to correlate solubility data. In addition, the results show that, the main contribution for NAP solubility in the aqueous DES solutions is the enthalpy.
Uterin leiomyomda Wnt, β-katenin, TGF–β, Siklin D1’in Ekspresyon seviyelerinin belirlenmesi
Authors: PENÇE Halime Hanım , KÖMÜRCÜ KARUSERCİ Özge , GÜZEL TANOĞLU Esra , UĞUR Mete Gürol
Published: October 2019

Amaç: Uterin leiomyomlar oldukça sık görülen
östrojen ve progesterone bağımlı benign tümörlerdir. Üreme çağındaki kadınlarda
görülebilir ve düzensiz uterin kanama, şiddetli anemi, tekrarlayan gebelik
kaybı gibi ciddi problemlere sebep olurlar. Her leiomyomun, tek bir mutasyona
uğramış myometrial düz kas kök hücresinden kaynaklandığı düşünülmektedir.
Bununla birlikte östrojen/progesteronun leiomyoma büyümesini nasıl düzenlediği
bilinmemektedir. Bu çalışmada Wnt,
β-katenin, TGF–β, siklin D1 genlerinin uterin leiomyom progresyoundaki
etkilerinin gösterilmesi amaçlanmıştır. Gereç ve
Yöntem: Gaziantep Üniversitesi Tıp
Fakültesi Kadın Hastalıkları ve Doğum Anabilim Dalı’na başvuran ve leiomyoma
tanısı alan 70 hasta ile 66 sağlıklı bireyden alınan dokular  çalışmaya dahil edilmiştir. Hasta ve
sağlıklı gruplar arasında genlerin ekspresyon farklılıkları kantitatif Realtime
PCR ile yapılmıştır.Bulgular:
Hastaların
ortalama yaşının 44,1±6,8 yıl olduğu bulunmuştur. Sigara içen hasta sayısının toplamda
8% olduğu ve gruplar arasında sigara kullanımı açısından fark olmadığı
saptanmıştır. Uterin leiomyom tanısına sahip hastalarda
Wnt, β-katenin, TGF–β,
siklin D1 genlerinin ekspresyon düzeylerinde sağlıklı
gruba göre belirgin bir artış olduğu istatistiksel olarak tespit edilmiştir.

Sonuç: Bu çalışmada Wnt, β-katenin, TGF–β, siklin
D1’in östrojen/progesteron’un leiomyoma oluşumu ve büyümesinde kritik bir
parakrin rolü olduğunu ortaya konulmuştur.
Endüstri 4.0’da Nesnelerin Kablosuz Etki Alanlarına Yapılan Saldırı Metodolojisi
Authors: SÜZEN Ahmet Ali , ŞİMŞEK Mehmet Ali , KAYAALP Kıyas , GÜRFİDAN Remzi
Published: October 2019

Bu çalışmada Endüstri
4.0 içerisinde yer alan nesnelerin iletişim kurdukları kablosuz ağ
bağlantılarının sızma, kırma ve taklit etme teknikleri uygulanarak zafiyet
testleri yapılmıştır. Sızma tekniği ile tespit edilen ağdaki tüm cihazların MAC
adreslerine erişim sağlanmaktadır.  MAC
adresi üzerinden de-auth atakları ile cihazlar ağdan düşürülmektedir. Bunun sonucunda
Endüstri 4.0 sistemlerinin çalışmasının kesintiye uğradığı veya belirli bir
süre durduğu görülmektedir. Kırma teknikleri ile WPS özelliği açık olan
dağıtıcıların standart şifreleri tahmin edilerek kablosuz ağa sızmanın veya ağı
devre dışı bırakmanın gerçekleştiği görülmektedir. Son olarak kablosuz ağda,
oturum taklit etme tekniği ile sisteme yeni bir cihaz ekleyip var olan
verilerin silinebileceği veya toplanabileceği görülmektedir. Elde edilen
sonuçlar ile kablosuz ağda kullanılan WEP, WPA ve WPA2 güvenliklerinin kendi
başlarına yeterli olmadığı görülmüştür. Yapılan sızma metodolojisi ile Endüstri
4.0 sistemlerinde veri güvenliğinin üst düzey olacağı bağlantılarda kablosuz ağ
kullanımının çözüm olmayacağı tespit edilmiştir.
Tramvay Durak Tasarımlarının Planlanması: Uşak Üniversitesi Örneği
Authors: ÖNER Jülide , KARA İsmet
Published: October 2019

Günümüz
koşulları göz önünde bulundurulduğunda sosyal, siyasal, kültürel ve en önemlisi
teknolojik gelişmeler neticesinde insanlar kentlerde yaşamayı daha çok tercih
etmektedir. Kent içi ulaşımda yaşanan trafik sıkıntıları sebebiyle
kullanıcıların ihtiyaçları göz önünde bulundurularak tasarlanmış çevreye daha
az zarar veren, daha gürültüsüz çalışan, konforu yüksek, daha hızlı ve daha
güvenli toplu taşıma araçlarının kullanılması zorunlu hale gelmektedir. Uşak
ili sürekli gelişen ve büyüyen, dışarıdan göç alan şehirlerden biridir. Bu
artış beraberinde Uşak ilinde de trafik sorunlarını gündeme getirmekte ve
trafik akışı zor hale gelmektedir. Bu çalışmanın amacı; tramvay sistemi
güzergahını belirlemek, tramvay duraklarının tasarımını yapmak ve tramvay
sistemleri ile Uşak şehri ve Uşak Üniversitesi kampüsü arasındaki trafikte
yaşanan sorunlara yönelik çözümleri değerlendirmektir. Ayrıca, çalışma
sonuçlarında Uşak şehri ile Uşak Üniversitesi kampüsü arasındaki yolun genel
özelliklerinden bahsedilmekte ve Uşak tramvay sistemi projesinin gerekliliği
vurgulanmaktadır.
Peyzaj Mimarlığında Minimalist Yaklaşımlar ve Tasarım Kriterleri
Authors: IRMAK Mehmet Akif , BİLGE Cihad
Published: October 2019

Minimalizm, 1960 sonrası Post-Modern Dönem akımı olup,
Fransızca kökenli olan “minimum” anlamına gelen “minimal” sözcüğünden
türetilmiştir. Bir ihtiyaç veya birey için gerekli olan en az veya en küçük
miktar olarak tanımlanmaktadır. Minimalizm, sadeliği ve nesnel yaklaşımı
savunan bir akımdır. Sanatta ve mimaride sadelik, basitlik ve azlık
kavramlarını öne çıkarmakta, kullanılan materyali minumuma indirgemektedir.
Bunun nedeni modernizmin sonucu olarak gerçekleşen ve yaygınlaşan teknolojinin
toplum üzerinde oluşturduğu, yoğun, sıkıcı kalabalığı, mental yorgunluğu ve
stresi dağıtmaktır. Minimalizm akımının sadelik, basitlik, azlık
kavramlarını ve indirgeyici yaklaşımını öne çıkarması, mimarlık ve peyzaj
mimarlığında etkili olmuş ve son dönemlerde tasarımcıların minimalist
tasarımlara yoğunlaşmasına neden olmuştur. 
Çağdaş peyzaj mimarlığında, minimalizm akımının etkileri özellikle
1960’lı yıllardan sonra görülmeye başlanmıştır. Minimalizm akımı peyzaj
mimarlığından sadelik, basitlik ve azlık kavramını ön plana çıkarırken, basit
geometrik biçimlere ve saf renklere yer vermiştir. Minimalist tasarımlarda
sadelikte bütünlük ve mükemmeliyetçilik anlayışı hâkimdir. Bu çalışma kapsamında minimalizm ve minimalist tasarım
anlayışına Peyzaj Mimarlığı açısından bakılarak, temel kriterler ortaya
konulmuştur. Bu kapsamda Türkiye dışında 13 farklı ülke ve 30’a yakın şehirden
değişik dönemlerde incelenmiş peyzaj alanlarından minimalist tasarım özelliği
gösteren tasarımlar örneklenmiştir. Ayrıca Türkiye’de çeşitli kentlerden
incelenmiş peyzaj tasarımları üzerinde minimalizm kriterleri ortaya
konulmuştur.  Amacı en az malzeme ile en
sade, en ekonomik ve en işlevsel sonucun ortaya konulması olan minimalist
tasarımların peyzaj çalışmalarında; bitki kullanımında, sert zemin uygulamalarında,
donatı seçiminde ve tasarım sınırlarının belirlenmesindeki temel kriterleri
değerlendirilmiştir. Minimalist tasarım anlayışının peyzaj çalışmalarında
getirdiği yenilikler ve faydalı yönler üzerinde durulmuştur.
Yenilenen Park Alanlarında İklim Odaklı Tasarımlar: Erzurum Kentsel Dönüşüm Alanı Örneği
Authors: YILMAZ Hasan , YILMAZ Sevgi , MUTLU Emral
Published: October 2019

Günümüzdeki uygulanan parklarda sert zemin oranlarının gitgide arttığı çalışmalar ortaya çıkmakta ve bitkisel materyal kullanımı azalmaktadır. Ayrıca yeni yapılan parkların çoğunda işlevsellikten önce estetik değere sahip bitkisel materyallerin kullanıldığı görülmektedir. Bu gözlemler sonucunda sert zeminlerin artmasının kentlerimizdeki iklimi nasıl etkilediği merak konusudur. Çalışma alanı Erzurum Kalesi’nin batısında yer alıp kentsel dönüşüm alanı kapsamında bulunmaktadır. Mevcutta otopark olarak kullanılan ve ezilmiş toprak örtüsüne sahip alana; 5 farklı senaryo ile beraber sert zemin oranlarının değiştiği tasarımlar yapılmıştır. Yapılan tasarımlar ENVI-met programıyla değerlendirmeye alınmıştır. Bu tasarımlar kapsamında sert zemin oranı arttıkça iklim odaklı dış mekan termal konforunun olumsuz yönde etkilendiği çalışma sonucunda tespit edilmiştir. Yapılan bu tespitler Predicted Mean Vote (PMV) standartlarına göre belirlenmiştir. Ayrıca çalışma sonucunda bitkilerin kullanım şekilleri ve yerlerinin de önem kazandığı sonucuna varılmıştır. Çalışma alanında park içerisindeki dış mekan termal konforunu etkili bir şekilde arttıran parametreler; yeşil alanların artması, ağaçların kullanılması ve çalıların ağaçlarla birlikte kullanılması olarak belirlenmiştir. Sonuç olarak; tasarım yapılan park alanı için yeşil alan kullanımı oranı azaldıkça, dış mekan termal konforunun “termal stressiz” aralığından “hafif sıcaklık stresli” ya da “sıcaklık stresli” aralığına geçiş yaptığı tespit edilmiştir.
Soğuk İklim Bölgeleri İçin Yeni Bir Açık-Yeşil Alan Anlayışı; Yıl Boyu Peyzaj/Peyzaj 12
Authors: YILMAZ Hasan , Gheshlagh Sofla Naiyer , Aksu Ayşegül
Published: October 2019

Artan kentleşme hareketlerine bağlı olarak kentlerde
açık-yeşil alanlarınn önemi işlevsel, ekolojik, estetik, ekonomik,
sosyo-kültürel açıdan giderek artmaktadır. Son zamanlarda ortaya çıkan millet
bahçesi uygulamaları kentsel açık-yeşil alanların artırılması açısından oldukça
yararlı görülmektedir. Bununla beraber kentlerin doğal ve kültürel kaynak
değerleri ile barışık ve bütün yıl boyu kullanıma açık, özgün kentsel
tasarımlara ihtiyaç vardır. Erzurum kenti özellikle yüksek rakımla beraber ortaya
çıkan extrem ikli şartları nedeni ile diğer kentlerimizden ayrıcalık
göstermektedir. Bundan dolayı dış mekanlarda gerek yapısal gerekse bitkisel
tasarım ve uygulamalarda klasik anlayışın dışında yeni yaklaşımlara ihtiyaç
duyulmaktadır. Kentte mevcut açık-yeşil alanların esnek ve dönüştürülebilir
olarak bütün yıl boyu kullanımına yönelik uygulamalar yeterli değildir. Bu
nedenle Erzurum gibi extrem iklim şartlarına sahip kentlerimizde kolay
erişilebilen, ucuz, yıl boyu kullanılbilen, konforlu, güvenli, aktif ve pasif
rekreasyon fırsatlar sunan kamusal dış mekanlar yeni bir anlayışla ele
alınmlıdır. Bu çalışmada dünyadaki az sayıda örnekleri bulunan
dönüştürülebilen kapalı peyzaj alanları değerlendirilerek, bölgemize ve
ülkemize bir model oluşturması hedeflenen Erzurum için yeni bir konsept olarak
ilk kez kapalı peyzaj kavramı üzerinde durulmuştur. Çalışma sonucunda bu amaca
yönelik mimari bir model oluşturulmuştur. Kentte marka değeri kazandıracak ve
kent insanına tüm yıl boyunca rekreasyonel fırsatlar sunması hedeflenen
komplekste açık-yeşil alanlar, buz müzesi, mini arberatum (bitki müzesi),
yöresel el sanatları müzesi, gastronomi vb. ünitelerle desteklenecektir. Peyzaj
12 kavramı olarak ilk kez tanımlanan kompleks ile açık-yeşil alanların yıl boyu
kullanılması hedeflenmektedir. Ülkemzdeki kapalı peyzaj uygulamasının ilk
örneğini oluşturacak bu özgün yapı, sadece kent halkının rekreasyonel
taleplerini karşılamakla kalmayıp, aynı zamanda kentin turizminin de
çeşitlendirilmesine katkı sağlayacaktır.
Agarose Gel Electrophoresis v1
Authors: Balletbó Alba , Kuiper Sebastiaan
Published: October 2019

Gel electrophoresis is the standard lab procedure for separating DNA by size (e.g., length in base pairs) for visualization and purification. Electrophoresis uses an electrical field to move the negatively charged DNA through an agarose gel matrix toward a positive electrode. Shorter DNA fragments migrate through the gel more quickly than longer ones. Thus, you can determine the approximate length of a DNA fragment by running it on an agarose gel alongside a DNA ladder (a collection of DNA fragments of known lengths).
Theoretical Approaches to the Concept of Responsibility of Members of Political Parties and its Correlation with Legal Responsibility
Authors: Mamedova V. Е.
Published: October 2019

The paper proposes the author’s understanding of responsibility of members of political parties provided by the political parties’ constitutions and other intraparty documents (intraparty responsibility). Also, the paper demarcates intraparty responsibility, legal and other types of social responsibility. It is concluded that the responsibility of members of political parties is a subspecies of social and statutory responsibility. The study has determined the tendency of convergence (diffusion) of internal party and legal responsibilities; the analysis has been carried out concerning perspectives of treating the responsibility of members of political parties as positive; the author substantiates the conclusion about the need to study intraparty responsibility exclusively in retrospective aspect. The author elucidates the thesis concerning expediency of enforcement of intra-party penalties as the subject matter of responsibility of members of political parties. Also, the basic properties of intra-party responsibility are revealed and analyzed. The study has investigated the influence of ambivalent nature of political parties and peculiarities of intra-party relations regarding the properties of responsibility of members of political parties.
Final and Intermediate Court Decisions in the Context of Unification and Differentiation of Court Proceedings in Criminal Procedure
Authors: Burmagin S. V.
Published: October 2019

The paper investigates normative-legal concepts of final and intermediate court decisions in criminal proceedings. Having carried out verbal and semantic and subject-content analysis of these definitions, the author reveals their drawbacks in terms of the terminology used and fictiousness in terms in the context of their subject matter. It is stated that the concept of an interim court decisions includes heterogeneous judicial acts fundamentally different in their nature and purpose. On the basis of the provisions of the theory of differentiation of criminal proceedings and the application of the method of systemic and structural analysis of the procedural activity of the criminal court, it is concluded that judicial acts and the final decisions of higher courts have common characteristics of final court decisions and should not be classified as interim, i.e. auxiliary. It is proposed to limit the concept of an interim judgment to a set of preparatory decisions, decisions to enforce and organizational decisions taken by the court in the course of preparation and conduct of a trial in any criminal proceedings.
Concept, Features and Legal Nature of Global Research Infrastructure
Authors: Kozheurov Ya. S. , Teymurov Е. S.
Published: October 2019

The term “unique scientific installation of the mega-science class” has firmly entered the circulation of legal acts of a program nature, which makes it necessary to study it from a legal point of view, to determine the relationship of this concept with the widely recognized term “global research infrastructure”. Based on the analysis of legal acts, program documents and doctrinal sources, two key features of “unique scientific installations of the mega-science class” can be distinguished: large scale (physical, financial, technological) and special significance for science, which allows for a certain breakthrough in a particular field of knowledge. The study of the essence of global research infrastructures suggests the following definition. It is constructed and operated through international cooperation (collaboration) of states, international organizations and other actors that do not have an international legal personality (government agencies, scientific institutions, funding institutions), physically large, expensive, unique in terms of technical characteristics equipment sets intended for long-term scientific research aimed at obtaining new breakthrough knowledge, significantly supplementing or changing ideas about the reality. Domestic term “unique scientific installation of “mega-science” (international) class” has the longest match with such global research infrastructure as geographically localized (single-sited) major research infrastructure. In order to bring legal terminology on “mega-science” into line with the global one, amendments should be made to the draft federal law “On Scientific, Scientific and Technical and Innovative Activities”.
Formation of a European Research Area in Evolution of Legal Regulation of European Research
Authors: Slepak V. Yu. , Ariyants A. A.
Published: October 2019

Since the end of the 20th century in Europe, there has been a tendency to accumulate scientific knowledge, increase the level of competitiveness of European research and the mobility of scientists themselves. The goals and objectives set by the European Union are realized through the creation of a single European research area and the implementation of special framework programs. It is determined that today the European Union is one of the world leaders in research and innovation. It is scientific knowledge, experience, high standards of research, developed research infrastructure that guarantee many years of successful cooperation between the EU and other countries. Contacts between Russia and the EU in the field of scientific and technical cooperation are developing quite actively. Both in the EU and in Russia, the development of effective innovation policies and programs is important for the development of a knowledge-based economy and an increase in the efficiency of investments in research and development.
Precarious Employment Trend: Features of its Development in Labor Legislation and the Problems of Other Norms of Industry Affiliation Influence on the World of Work, Taking into Account International Labor Standards
Authors: Ramankulov К. S.
Published: October 2019

The paper notes that the conceptualization of the basic concepts related to precarious employment and the adoption of norms and legal acts adequate to these relations in the system of labor legislation of the states of the Eurasian Economic Union (EAEU) are at the preparatory stages. In the paper, the features of the manifestation of precarious employment in the labor legislation of the EAEU countries are analyzed by the example of norms on a fixed-term labor contract taking into account international labor standards. The labor legislation of the EAEU countries shows a tendency to expand the scope of fixed-term employment contracts, including towards lowering the level of legal guarantees for workers (Article 41 of the Labor Code of Belarus, Article 30 of the Labor Code of Kazakhstan, Article 82 of the Labor Code of Kyrgyzstan, Article 348.12 of the Labor Code of Russia), which contradicts the rules of ILO Recommendation No. 166 on the termination of labor relations on the initiative of the employer (Article 3) and the fundamental Convention No. 105 on the abolition of forced labor (Article 1), ratified by all states of the Eurasian Economic Union. In the paper, in the context of the development of precarious employment, the problems of the influence of norms of a different sectoral affiliation on the world of work are analyzed (by the example of Kyrgyzstan). It is noted, in particular, that the practice of applying the patent system to regulate the world of work does not contribute to resolving the issues of legalization of labor relations, and the tax authorities are not motivated to prove the existence of labor rather than civil law relations, even when they meet the criteria set forth in the ILO Recommendation No. 198 on labor relations and in Art. 13 of the Labor Code of Kyrgyzstan. The conclusion is formulated in relation to the restrictions of the labor inspectorates established by the Law of the Kyrgyz Republic dated May 25, 2007 No. 72 and by the Decree of the Government of the Kyrgyz Republic dated December 17, 2018 No. 586 as contrary to the ILO priority Convention No. 81 on labor inspection in industry and trade (Part 1 of Article 12) ratified by Kyrgyzstan. Serious inconsistencies of measures to deregulate administrative responsibility to the tasks of the labor legislation of Kyrgyzstan to counteract precarious employment are identified.
Legal Regulation of the State-Owned Real Estate Disposal
Authors: Gordienko I. I.
Published: October 2019

The paper discusses the problems associated with the state-owned real estate disposal. Two groups of objects that have the features of disposition and disposal are distinguished: objects whose disposition and disposal occur in a general manner after removal of their special status (cultural heritage objects, protective structures), and objects whose disposition and disposal are regulated by special legislation in connection with the special purpose of such objects (housing, subsoil use, water transport). Features of the disposal of such facilities, in particular the need to remove special status prior to the disposal of the facilities, are considered. The problem of registration of rights to land plots under objects that are subject to demolition or are virtually absent is considered. It is concluded that it is necessary to improve the legislation regarding the disposal of facilities, including the development of a procedure for the sale of materials resulting from the demolition of capital construction facilities.
Operative delivery in pregnant women with asthma
Authors: Lavrova Olga V. , Shapovalova Elena A. , Dymarskaya Yulia R. , Sudakov Dmitry S. , Paliychuk Anna V.
Published: October 2019

Hypothesis/aims of study. Asthma is the most common chronic disease of the respiratory system in women during pregnancy. Numerous studies show an increased frequency of all complications of pregnancy and delivery by cesarean section in women with asthma. Such delivery is reported to be observed more often in patients with severe asthma and asthma exacerbations during gestation. There are conflicting data showing that the use of asthma medication increases the risk of complications of pregnancy and childbirth. This study aimed at analyzing the frequency of cesarean section in patients with asthma, depending on the severity, course, and control of the disease.

Study design, materials and methods. This retrospective study involved data of 170 patients with varying severity and control of asthma, who were under the supervision of a pulmonologist from the first trimester of pregnancy. According to the severity of asthma, patients were divided into subgroups with mild intermittent, mild persistent, and moderate and severe course of the disease. The control group was represented by 30 patients who did not suffer from any pulmonary and allergic diseases.

Results. The cesarean delivery rate in patients with asthma in the whole group was significantly higher than in patients of the control group. Exacerbation of asthma during pregnancy significantly increases the frequency of abdominal operative delivery, and the use of modern drugs to achieve control of asthma during pregnancy has a positive effect and is associated with a lower birth rate by cesarean section.

Conclusion. The active simultaneous management of pulmonary problems in pregnant women allows timely and adequate therapeutic measures aimed to achieve control of asthma during pregnancy, thereby reducing obstetric and perinatal risks, including those associated with the method of delivery.
Vaginal microbiocenosis in the prenatal and postnatal periods
Authors: Dadayeva Dzhamilya G.
Published: October 2019

The article presents literature data on vaginal microbiota status during full-term pregnancy, placental microbiota status, and the characteristics of the vaginal microbiocenosis in the postpartum period. The main topic of the publication is the role of the prevailing Lactobacillus species and conditionally pathogenic microflora of the vagina and placenta in obstetric practice.
Principles of diagnosis of ovarian neoplasms — minimization of errors
Authors: Protasova Anna E. , Tsypurdeyeva Anna A. , Tsypurdeyeva Natalia D. , Solntseva Irina A.
Published: October 2019

Ovarian cancer mortality rates hold a leading position among women’s cancer, which is primarily associated with the pathogenetic features of ovarian cancer, the heterogeneity of the disease, the lack of effective screening and diagnostic methods for early cancer detection. The causes of most ovarian tumors remain unknown. Ovarian benign tumors and tumor-like formations are not among the risk factors of ovarian cancer. The purpose of this literature review is to highlight the latest data from world expert organizations on the possibilities of ovarian neoplasm diagnosis and treatment.
Application of the laryngeal mask airway in cesarean section
Authors: Shadenkov Valery I. , Korostelyov Yury M. , Vartanova Irina V. , Shirokov Dmitry M.
Published: October 2019

Spinal anesthesia is considered the standard anesthetic technique for elective cesarean section, but it is contraindicated in some cases. General anesthesia in pregnant women is associated with a significant increase in frequency of complications, primarily related to airway management. In this article, we propose to use a laryngeal mask airway as an alternative to endotracheal intubation during elective operative delivery, subject to certain conditions. We present two clinical cases of general combined anesthesia with the installation of a second-generation laryngeal mask airway and mechanical ventilation — in a patient with the Arnold-Chiari type I malformation and in a patient with IV grade scoliosis.
Optimization of Cloning Conditions for High-level Production of Recombinant Mouse Interleukin-2 in Escherichia coli
Authors: Abdi Arezou , Hosseinpour Mitra , Mashayekhi Kazem , Javad Mousavi Mohammad , Elham Badiee Kheirabadi Seyedeh , Sankian Mojtaba
Published: October 2019

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Basil and Dracocephalum kotschyi Alcoholic Extracts Affect BCL2 expression and HepG2 Cell Proliferation
Authors: Moghimi Mansour , Rashidian Sara , Khosravian Farinaz , Hadi Nasrin
Published: October 2019

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TEM Gene Detection in Clinical Pseudomonas aeruginosa and Escherichia coli Samples
Authors: Shams Elahe , Nateghi Behnaz , Eshaghiyan Amir , Behshood Parisa
Published: October 2019

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ANALYSIS OF FOREIGN EXPERIENCE IN THE REGULATORY FRAMEWORK OF DISTRIBUTED LEDGERS AND ICO (INITIAL COIN OFFERING) WITHIN INNOVATIVE ECONOMY
Authors: G.F. Ruchkina , D.N. Ermakov
Published: October 2019

Purpose: The article analyzes the content of economic and legal mechanisms of state control over the emerging market of ICO (Initial Coin Offering). Methodology: This was analytical-logical research based on content analysis. Result: Regarding the considered areas of legal regulation, it is worth noting that in regulating the protection of intellectual rights, counteracting legalization and laundering of money obtained by criminal means, as well as in regulating the protection of personal data, most states use the current legislation without any changes. Applications: This research can be used for universities, teachers, and students. Novelty/Originality: In this research, the model of the analysis of foreign experience in the regulatory framework of distributed ledgers and ICO (initial coin offering) within innovative economy is presented in a comprehensive and complete manner.
THE INCLUSIVE VILLAGE OF INDONESIA (INTERFAITH TOLERANCE MODEL IN BALUN VILLAGE, LAMONGAN)
Authors: Huda Sholihul
Published: October 2019

Purpose: This paper is the result of field research that aims to describe the model of tolerance among Muslims, Christians, and Hindus in the Balun Village Turi District of Lamongan Regency Indonesia. In addition, this research wants to encounter the International opinion which thinks that Lamongan as Terrorist Village.

Methodology: The data are analyzed using multidisciplinary science, meaning depending on the data obtained, if obtained religious data then the analysis used is the study of religion and so forth.

Result: The results of the study are: the first, Balun's religious paradigm in understanding his religious doctrines is an inclusive sub-paradigm. The second, the cultural background of tolerance in Balun is the factor of understanding the inclusive, sub-inclusive religious doctrines, pluralist political policies, tolerant socio-cultural traditions, the different religious traditions of marriage. The built tolerance models are: the first is the Plural Village Structure (Tool). The second is Multicultural (Democratic) Family, the third is “Ngaturi / Kenduri” Multicultural, the fourth is Inclusive Da'wah and the fifth is Multicultural Tombs. Balun village can be seen as an inspiration and a mirror for the people of Indonesia which are prone to conflict between people, so our hope to build a united, tolerant, progressive, peaceful and harmonious Indonesia can be realized.

Applications: This research can be used for universities, teachers, and students.

Novelty/Originality: In this research, the model of the inclusive village of Indonesia is presented in a comprehensive and complete manner.
ANALYSIS OF THE FACTORS THAT INFLUENCE CUSTOMER PURCHASE INTENTION TOWARDS LUXURY FASHION GOODS
Authors: Hashim Haniza , Abdullah Saleha , Shafee Nur Baiti , Suhaimi Shadia , Ching Tai Siew
Published: October 2019

Purpose: Malaysia is an important luxury market and this luxury industry wills growth in the future because of the demand from young Malaysian consumers. Therefore, the purpose of this study is to examine the influencing factors that affect Malaysian Consumers’ purchase intention towards luxury fashion goods and their relative importance.

Methodology:  Questionnaires had been distributed to 200 respondents. Data had been analyzed using SPSS to identify whether factors such as materialism, social comparison, and brand consciousness have a significant relationship with the intention to purchase luxury fashion goods. 

Results: Results indicated that materialism and brand consciousness has a positive relationship with the purchase intention of luxury fashion goods in Malaysia.

Implications: Malaysian consumers are more conscious and more aware of the unique brands to give prominence to their self-identity.
PERSPECTIVE OF MAX WEBER’S THESIS ON THE ETHICS OF PROTESTANTISM AND ITS RELEVANCE TO THE STYLE OF CHRISTIANITY IN MALUKU
Authors: Pariyama Leonardo Stevy , Siang Jhoni Lagu
Published: October 2019

Purpose of study: This study aims to explain Max Weber's thesis on the ethics of Protestantism and its relevance to the style of Christianity in Maluku.

Methodology: The method used in this study is descriptive qualitative with an inductive approach. Data analysis will use metaphor, narration, and semiotics as a step to place historical facts into qualitative data related to research problems.

Main Findings: The results achieved in this study are that the reality of Protestantism in Maluku is especially at the GPM, in its correlation with Weber's Thesis it is clearly stated that Protestant Calvinists are people who survive and save so that they succeed in the economic world and become capital owners (Capitalism), on the contrary, the Calvinist Protestants in Maluku (GPM) did not show that attitude.

Implications: This concludes that Protestant Ethics as a contextual demand in this study was put forward because of the attention to the context of the meaning and articulation of contemporary Protestantism in Maluku.
CURRENT VIEW ON ANTICOAGULANT AND THROMBOLYTIC TREATMENT OF ACUTE PULMONARY EMBOLISM
Authors: Taradin G. G. , Ignatenko G. A. , Vatutin N. T. , Kanisheva I. V.
Published: October 2019

The presented review concerns contemporary views on specific aspects of anticoagulant and thrombolytic treatment of venous thromboembolism and mostly of acute pulmonary embolism. Modern classifications of patients with acute pulmonary embolism, based on early mortality risk and severity of thromboembolic event, are reproduced. The importance of multidisciplinary approach to the management of patients with pulmonary embolism with the assistance of cardiologist, intensive care specialist, pulmonologist, thoracic and cardiovascular surgeon, aimed at the management of pulmonary embolism at all stages: from clinical suspicion to the selection and performing of any medical intervention, is emphasized. Anticoagulant treatment with the demonstration of results of major trials, devoted to efficacy and safety evaluation of anticoagulants, is highlighted in details. Moreover, characteristics, basic dosage and dosage scheme of direct (new) oral anticoagulants, including apixaban, rivaroxaban, dabigatran, edoxaban and betrixaban are described in the article. In particular, the management of patients with bleeding complications of anticoagulant treatment and its application in cancer patients, who often have venous thromboembolism, is described. Additionally, modern approaches to systemic thrombolysis with intravenous streptokinase, urokinase and tissue plasminogen activators are presented in this review. The indications, contraindications, results of clinical trials devoted to various regimens of thrombolytic therapy, including treatment of pulmonary embolism by lower doses of fibrinolytic agents, are described.
PERFORMANCE OF THE VASCULAR STIFFNESS INDICATORS AND THE PROCESS OF LEFT VENTRICLE REMODELING IN HYPERTENSIVE PATIENTS UNDER RENAL REPLACEMENT THERAPY
Authors: Praskurnichiy E. A. , Minyukhina I. E.
Published: October 2019

Objective. The objective of our study was to compare the performance of vascular stiffness (VS) and the left ventricular (LV) remodeling process indicators in patients with arterial hypertension (AH) under renal replacement therapy (RRT), and patients with essential hypertension.

Design and methods. 158 people were included in the study, divided into 4 comparable age groups: 32 patients receiving programmed hemodialysis (PH), 37 recipients of renal transplant (RT), 69 patients with essential AH and 20 healthy volunteers. All the patients underwent 24-hour blood pressure (BP) monitoring with an assessment of VS and central BP (SBPao) and echocardiography (EchoCG).

Results. The patients under PH and after RT did not have any significant differences in the values of central and peripheral BP. Comparing the groups of patients under RRT with the group of essential AH, the office systolic (SBP) and diastolic (DBP) BP values did not differ significantly. Аlthough, at night, considerably higher DBP(n) and SBPao(n) values were detected in patients under RRT, and in the patients after RT SBP(n) and PP(n) values were also increased. An increase in the SBPao values of more than 10 m/sec was detected only in the groups of patients under RRT. In all the groups with hypertension all indicators of daily VS differed significantly from the group of healthy volunteers. PTIN (Pulse Time Index of Norm) in the studied groups had more evident differences: in the healthy volunteers it was in the range of 80-90%, in the patients with essential hypertension — 50-60%, and in the patients under PH and after RT — 20-40%. In all groups of patients with AH, the average the posterior wall thickness (PWT) of the LV and the interventricular septum thickness (IVST) were close to the upper limit of the norm. In the groups of patients with AH an increase in the relative wall thickness (RWT) of the LV was also detected. Furthermore, considerably higher the values of ILVmass, IVST were found in the group of patients on PH in comparison with the patients after RT. In addition, in all the groups of patients with AH, there was a tendency to LV spherification in comparison with the healthy volunteers, and in the group of essential AH the difference was more pronounced compared with the group under RRT.

Conclusion. In the patients with arterial hypertension who undergo renal replacement therapy, higher average values of central BP, higher vascular stiffness (daily pulse wave velocity in the aorta and a longer period of pulse wave velocity increase in the aorta during the day (PTIN)) and less pronounced left ventricular spherification are recorded in comparison with the patients with essential hypertension while office BP values remained consistent.
ANALYSIS OF ENVIRONMENTAL ASPECTS AT MEAT PROCESSING PLANTS ACCORDING TO ISO 14001
Authors: Kuzlyakina Yu. A. , Yurchak Z. A. , Baskhamdgieva B. D.
Published: October 2019

The purpose of this article was to represent the environmental indicators of meat production chain and highlight the main environmental aspects. Meat industry is recognized as one of the leading polluting industries in food production. Meat production chain was analyzed in terms of three levels of environmental aspects: severity of impact, probability, and the calculated quantitative estimate of the emerging aspects. Meat production requires natural resources (water and energy), which leads to the discharge of waste and wastewater. As a result, it has a major impact on climate change, consumption of natural resources and environmental pollution. Future research should focus on the environmental impact of meat production chain in terms of existing and newly developed environmental indicators and on finding solutions to reduce the overall environmental impact.
Biological Activities and Phytochemical Constituents of Trailing Daisy Trilobata: A Review
Authors: Sai Prasanna K , Jyothi Reddy G , Kiran M , Thyaga Raju K
Published: October 2019

The traditional system of medicinal plants have been found to possess significant anti-inflammatory, antibacterial, anti-fungal, anti-diabetic, analgesic properties etc. Plant-derived drugs are used to cure mental illness, skin diseases, tuberculosis, diabetes, jaundice, hypertension, and cancer. Wedelia Trilobata belongs to family Asteraceae. Leaf, stem, and flower of Wedelia trilobata show anti-microbial, anti-oxidant and anti-inflammatory activity, analgesic activity. Phytochemical screening of the extract has been reported to show the presence of tannins, cardiac glycosides, flavonoids, terpenoids, phenols, saponins, and coumarins. Wedelia Trilobata is also used in reproductive problems, amenorrhea, chest cold, dry cough, and fever. The present review aims to the study was phytoconstituents, biological and pharmacological activities of Wedelia trilobata. This study suggested a possible use of Wedelia trilobata as a source of natural medicines as an anti-inflammatory, anti-oxidant, anti-microbial, hepatoprotective, antidiabetic agents.

Keywords: Wedelia Trilobata, Trialing daisy trilobata, Complaya trilobata(L), Sphagneticola Trilobata, pharmacological review.
Analytical method development and validation of L-Carnitine L-Tartarate in Pharmaceutical Dosage forms (Multivitamin tablets) using non aqueous titration
Authors: Kumar Sunil , Ram Bigan
Published: October 2019

The   Non aqueous titration   method was developed for quantitave analysis of  L-  Carnitine L-Tartarate    in  multivitamin  tablets. The   Non aqueous titration method was carried out using 0.1  N  Perchloric acids. The   present   analytical    method   was validated according to ICH guidelines  (ICH,Q2(R1)).  The   calibration   curve   was  found    to   linear  with correlation coefficient   (r2=0.99995),  Bias   (-0.35)  in  the  range  of  50  to 150  %  of  standard solution. The   precision   and   recovery   were determined   and  all  the  parameter value found within acceptance  limit. The  value  for  both method  and intermediate  precision were found to 0.57 % and recovery  found  to 99.11 to 99.59 %.  The   validation parameter  study  was  method  precision,  intermediate   precision,   Linearity   and   recovery.  This is a   convenient, precise   and   rapid    accurate  method    for  the estimation  of   L-Carnitine  L-Tartarate  in  Bulk  and Pharmaceutical dosage forms (Multivitamin Tablets).

Keywords: AIDS, Linearity, Correlation coefficient, Bias, Precision and Recovery
A lei do piso salarial estadual: uma conquista dos trabalhadores catarinenses
Authors: Silva Mauri Antonio da
Published: October 2019

O artigo analisa, por meio de estudo bibliográfico, a resistência dos trabalhadores à sua exploração pelo capital. Ao sentirem os efeitos da crise mundial do capitalismo os empresários brasileiros tentam rebaixar os custos com salários para retomar suas altas taxas de lucro e passam a defender o fim dos pisos salariais estaduais de categorias e uma reforma trabalhista para reduzir o valor da força de trabalho. Os resultados de nosso estudo mostram que através de uma ação propositiva do movimento sindical, que ocorre no Estado de Santa Catarina, as centrais sindicais se mobilizaram e conquistaram reajustes do Piso Salarial Estadual, instituído por lei estadual, conquistando ganhos reais acima da inflação oficial.
Serviço social, Projeto Ético-Político profissional e o debate da consciência
Authors: Moreira Tales Willyan Fornazier
Published: October 2019

Este trabalho apresenta elementos que particularizam os fundamentos do Serviço Social no Brasil, em seu movimento histórico e teórico. Trata da aquisição de seu estatuto profissional no marco da era dos monopólios. Recupera o processo de constituição da direção social da profissão, sobremaneira a partir da década de 1990, após interlocução com a teoria marxista, destacando sua organização política. É neste período também que a profissão adquire maturidade intelectual, teórica e ético-política e avança em termos de construção de seu projeto profissional. A partir destes elementos, estabelecemos a interlocução com o debate da consciência com base nos postulados de Marx e Engels. Findamos as reflexões compreendo a importância deste debate para o Serviço Social e a necessidade de avançar nesta interlocução.
Formação profissional e conservadorismo: uma análise a partir dos/as estudantes do curso de Serviço Social do Instituto Federal de Educação Ciência e Tecnologia do Ceará
Authors: Moreira Ana Samilly Alexandre , Oliveira Mônica Ivo de
Published: October 2019

O Serviço Social é uma profissão que historicamente se constituiu sob bases conservadoras. Estas, nunca deixaram de permear a formação e o exercício profissional apesar dos avanços feitos pela categoria, não sendo também uma exclusividade desta profissão, mas próprias da dinâmica de reprodução do capital. O avanço e reatualização desse conservadorismo na sociedade exige uma urgente e imprescindível reflexão acerca dos seus rebatimentos para o Serviço Social. Assim, o presente estudo tem como objetivo geral compreender as incisões do conservadorismo na formação profissional, tendo como lócus de pesquisa o curso de Serviço Social do Instituto Federal de Educação Ciência e Tecnologia do Ceará (IFCE) Campus Iguatu. A pesquisa, de caráter qualitativo, utilizou como procedimentos metodológicos a pesquisa bibliográfica, documental e de campo, esta última realizada com estudantes do sétimo e oitavo semestres e apresentou os seguintes resultados: os/as estudantes possuem conhecimento razoável acerca do conservadorismo e de suas formas de expressão na sociedade e na profissão, o conservadorismo tem se expressado principalmente a partir de posturas moralistas e preconceituosas por parte de estudantes e funcionários/a da instituição, além do crescimento de vertentes tidas como conservadoras pelas análises da vanguarda profissional. Em relação às pautas societárias, os/as estudantes entrevistados/as se posicionam, majoritariamente, em consonância com o que tem apontado o projeto de profissão do Serviço Social.
Política sobre Drogas e Neoliberalismo: comunidades terapêuticas e debate no serviço social
Authors: Aragão Indira , Rosa Lucia Cristina dos Santos
Published: October 2019

Tem-se o objetivo de efetivar uma análise sobre como as medidas neoliberais adotadas pelo Estado brasileiro se fazem presentes na Política Nacional Sobre Drogas, como incidem diretamente no cuidado ao público alvo da política e o debate do Serviço Social neste contexto. Baseada em pesquisa bibliográfica, processa-se um recorte da discussão sobre a inserção das comunidades terapêuticas neste cenário e a transferência de recursos do fundo público para tais instituições. Tal direcionamento impacta a cidadania, reorientada para o consumidor, fortalece a lógica do Terceiro Setor e a desresponsabilização do Estado na execução direta das ações em torno da pessoa com uso abusivo de substância psicoativa.