bluuebunny/crossref_metadata_2025 huggingface dataset:
Expression of ER, PR and Ki-67 in tumor with different genetic variants of ESR and levels of antiidiotypic antibodies to steroid hormones in breast cancer patients
Authors: Glushkov A. N. , Polenok E. G. , Gordeeva L. A. , Mun S. A. , Glushkova O. A. , Zakharov V. N. , Antonov A. V. , Bayramov P. V. , Verzhbitskaya N. E. , Voronina E. N. , Kolpinskiy G. I.
Published: January 2025

Aim. To study the possible associations of tumor ER, PR and Ki-67 expression with ESR1 and ESR2 genes polymorphisms and blood serum levels of antiidiotypic antibodies IgG2-E2 and IgG2-Pg in breast cancer patients (BCP).

Materials and Methods. Blood serum levels of IgG2-E2 and IgG2-Pg were studied in 1025 BCP (478 with stage I and 547 with stages II-IV) by means of enzyme-linked immunosorbent assay. Real-time PCR was performed for ESR1

(rs2234693) and ESR2 (rs4986938) genes polymorphisms detection. ER, PR and Ki-67 positive tumor cells was determined using immunohistochemistry.

Results. IgG2-E2 and IgG2-Pg blood serum levels were not depended on ESR1 and ESR2 gene polymorphisms in BCP. ER+/PR+ tumors were revealed more frequently and ER-/PR- tumors less frequently in BCP at the I stage with high serum levels of both IgG2-E2 and IgG2-Pg than in BCP with their low levels: in patients with genotype TC ESR1 (91.8 % and 3.3 % vs 73.9 % and 11.1%, p = 0.015). Such differences were not revealed in patients with genotypes TT and CC ESR1. There were not discovered the desired association of ER/ PR tumor phenotype with studied antibodies and ESR2 genes polymorphisms. High levels of tumors Ki-67 positive cells (>20%) were determined less frequently in BCP at the II-IV stages with high levels of both IgG2-E2 and IgG2-Pg than in BCP with their low levels: in patients with genotypes TC ESR1 (48.4 % vs 69.7 %, p = 0.004) and GA ESR2 (46.8 % vs 66.3 %, p = 0.009). There were not revealed such differences in patients with other variants of ESR1 and ESR2 genotypes.

Conclusion. Synergistic effects of IgG2-E2 and IgG2-Pg were discovered in BCP: the maintenance of ER and PR in tumors at the I stage and inhibition of tumor proliferation at the II-IV stages.
Aktivitas Antidiabetes Ekstrak Gryllus Bimaculatus terhadap Penurunan Glukosa Darah Tikus Jantan (Rattus norvegicus) Diabetes
Authors: As'ari Hasyim , Nurmasari Fitri , Safitri Tika
Published: January 2025

Penelitian ini bertujuan untuk mengidentifikasi efek ekstrak Gryllus bimaculatus terhadap kadar gula darah dan kolesterol pada tikus diabetes (Rattus norvegicus). Metode yang digunakan adalah eksperimen laboratorium dengan desain acak lengkap (Randomized Complete Design) yang melibatkan lima kelompok perlakuan: kontrol negatif (Na-CMC 0,5%), kontrol positif (Glibenklamid 0,013 mg/kgBB), serta tiga kelompok yang masing-masing menerima ekstrak Gryllus bimaculatus pada dosis 12,5 mg/kgBB (P1), 25 mg/kgBB (P2), dan 50 mg/kgBB (P3). Setelah perlakuan, kadar gula darah dan kolesterol diukur menggunakan alat Easy Touch GCU pada penelitian hari ke-17 dan ke-25. Analisis data menggunakan uji Anova dan uji Duncan dengan IMB SPSS statistics 25. Hasil penelitian menunjukkan bahwa pemberian ekstrak pada dosis 50 mg/kgBB (P3) dapat menurunkan kadar gula darah mendekati normal selma 14 hari dengan penurunan sebesar 39,11% (dari 354,40 ± 7,53 mg/dL menjadi 215,80 ± 5,21 mg/dL), sedangkan kadar kolesterol menurun hingga 17,64% (dari 230,20 ± 2,79 mg/dL menjadi 189,60 ± 4,76 mg/dL). Analisis statistik menggunakan uji ANOVA menunjukkan perlakuan berpengaruh terhadap penurunan kadar gula darah, dan uji Duncan menunjukkan  seluruh kelompok perlauan ekstrak Gryllus bimaculatus  berbedanyata, dengan P3 memiliki efektivitas serupa dengan kontrol positif Glibenklamid. Kesimpulan penelitian ini menunjukkan dosis ekstrak Gryllus bimaculatus 50 mg/kgBB (P3) efektif dalam menurunkan kadar gula darah dan berpotensi sebagi alternatif dalam mengatasi hiperkolesterolemia.
SYNERGY OF INTELLECTUAL CAPITAL AND SHARIA FINANCIAL CAPITAL IN IMPROVING FINANCIAL PERFORMANCE
Authors: Albahi Muhammad , Yuslem Nawir , Soemitra Andri , Noor Mohd
Published: January 2025

This study aims to analyze the influence of Intellectual Capital and Sharia Financial Capital on the financial performance of companies listed in the Jakarta Islamic Index (JII) and to evaluate the synergy between the two capitals in increasing competitiveness and business sustainability. The data used are from the annual reports of JII companies during the period 2020–2024. Intellectual Capital is measured using the Value-Added Intellectual Coefficient (VAIC) model, and Sharia Financial Capital, which includes the zakat ratio, profit-sharing ratio, and Sharia debt ratio. Financial performance is measured using Return on Equity (ROE), Return on Assets (ROA), and Price-to-Book Value (PBV). The results show that Intellectual Capital and Sharia Financial Capital have a positive influence on financial performance. The synergy between Intellectual Capital and Sharia Financial Capital has been proven to have a significant impact, creating a substantial competitive advantage in the context of Maqashid Sharia.
Suun valtasairaudet nuorilla aikuisilla
Authors: Murtomaa Heikki
Published: January 2025

Katsauksessa tarkastellaan suun alueen kahden valtasairauden, karieksen ja hampaiden kiinnityskudossairauksien esiintyvyyttä suomalaisilla nuorilla aikuisilla. Epidemiologisia tutkimuksia on opiskelijoita lukuun ottamatta tehty vähän nuorilla aikuisilla. Terveyskeskushammashuollon seuruutulosten perusteella nuorten hammasterveys viime vuosikymmeninä on huomattavasti parantunut, joskin karieskokemus vaihtelee alueittain. Varusmiehiltä paikattujen hampaiden lukumäärä on suorassa suhteessa koulu- ja opiskeluvuosiin, kun taas paikkausta vaativien hampaiden ja kouluvuosien välillä yhteys on käänteinen. Ientulehdus on erityisesti yleistä nuorilla aikuisilla. Varusmiehillä myös sen esiintyminen vähenee kouluvuosien suhteessa samoin kuin verenvuotavien ienrajojen määrä. Neljänneksellä nuorista aikuisista tavataan syventyneitä ientaskuja. Opiskelijoilla suoritetut tutkimukset antavat viitteitä karieksen ja parodontiumin sairauksien aiheuttaman hoidontarpeen polarisoitumisesta. Vallitsevien väestöryhmittäisten erojen kaventaminen yleistyy myönteistä kehitystä vaarantamatta edellyttää nuorilla aikuisilla sosiaali- ja terveyspoliittisia toimenpiteitä.
Yksityinen hammashuolto osana suun terveydenhuoltoa
Authors: Masalin Kai
Published: January 2025

Yksityinen palvelujärjestelmä hammashoidossa on edelleen varsin laaja sen tarjotessa 60–70 prosenttia aikuisten tarvitsemista hammashoitopalveluista. Noudatettu hammashuoltopolitiikka on johtanut käytettävissä olevien voimavarojen kannalta erittäin epätarkoituksenmukaiseen järjestelmään ja voimavarojen tuhlaukseen. Nähtävissä on ollut pyrkimys rakentaa hammashuoltojärjestelmää paljolti muista tavoitteista lähtien kuin väestön tosiasiallisista tarpeista. Vuoden 1986 hammashuoltouudistus toi mukanaan mahdollisuuden muuttaa tähänastista menettelyä.
Uudistuksen tavoitteeksi on asetettu julkisen ja yksityisen sektorin toiminta siten, että ne yhdessä muodostavat tarkoituksenmukaisen kokonaisuuden. Tällöin yksityinen sektori voi toimia julkista sektoria täydentävänä järjestelmänä. Tavoitteen saavuttaminen edellyttää lukuisten nykyisin esiintyvien ongelmien selvittämistä. Olennaisen tärkeää olisi tavoitteiden konkretisoiminen osaksi päätöksentekoa. Tämä merkitsisi yksityisen sektorin kapasiteetin huomioon ottamista julkisen sektorin ratkaisuja tehtäessä sekä väestöä tasa-arvoisesti kohtelevan maksupolitiikan ja subventiopolitiikan toteuttamista.
Oleellinen perustekijä on myös suunnittelussa tarvittavien tietojen kerääminen, johon nykyinen lainsäädäntö jo antaa mahdollisuuden. Yksityinen ja julkinen sektori voivat toimia yhdessä ja muodostaa väestöä hyvin palvelevan kokonaisuuden. Tällöin tasa-arvo hammashoidossa sekä väestön että hammashuoltohenkilöstön kannalta voi toteutua, jos siihen vain löytyy tarvittava poliittinen ja muu tahto.
Geriatriset mielisairaalapotilaat
Authors: Salokangas Raimo K. R. , Mattila Vilho J. , Penttinen Jukka
Published: January 2025

Tutkimus kohdistuu mielisairaalassa olleisiin ja sinne puolen vuoden aikana tulleisiin turkulaisiin vanhuksiin, joita seurattiin noin neljän vuoden ajan. Tutkimuksen alkaessa mielisairaalahoidossa oli 13 vanhusta ja puolen vuoden aikana heitä tuli mielisairaalaan 51. Naiset olivat yliedustettuja molemmissa potilasryhmissä. Seuranta-aikana kotiutettiin 5 % sairaalassa olleista ja 53 % sairaalaan tulleista. Kuolleisuus oli sairaalassa olleiden ryhmässä suurempi (53,5 %) kuin sairaalaan tulleilla (45,9 %). Sukupuoli, ikä, siviilisääty ja psykiatrinen diagnoosi liittyivät potilaiden mielisairaalahoidon käyttöön seuranta-aikana.
Tutkimuksen tulokset tukivat käsitystä, jonka mukaan sosiaalisen kanssakäymisen väheneminen vanhuksilla voi myötävaikuttaa heidän sairastumiseensa psyykkiseen häiriöön sekä joutumiseensa pitkäaikaiseen mielisairaalahoitoon. Lopuksi tehtiin eräitä ehdotuksia vanhusten aseman ja heidän hoitonsa parantamiseksi.
Nuorten ja heidän vanhempiensa käyttämä leipärasva ja maitolaatu sekä niihin liittyvät terveysuskomukset
Authors: Vartiainen Erkki , Leskinen Sirkku , Tossavainen Kerttu
Published: January 2025

Yhdeksäsluokkalaisten oppilaiden ja heidän vanhempiensa käyttämää leivänrasvaa ja maitolaatua sekä niihin liittyviä terveysuskomuksia tutkittiin Itä-Suomen nuorisoprojektin peruskartoituksessa. Noin 2/3 käytti leivänrasvana voita, noin 20 % jääkaappimargariinia ja runsaat 10 % voimariinia. Vajaa kolmannes pojista ja runsas kolmannes tytöistä sekä noin puolet vanhemmista uskoivat voin nostavan veren kolesterolitasoa. Joka kolmas vastaaja piti jääkaappimargariinia terveellisemmän kuin voita. Yleisimmin käytetty maitolaatu oli kevytmaito. Pojat käyttivät rasvaisia maitolaatuja useammin kuin tytöt. Rasvatonta maitoa piti epäterveellisempänä noin 10 % vastanneista.
Vanhempien ja lasten ruokavalioiden välillä oli voimakas riippuvuus. Terveysuskomuksilla oli kohtalaisen voimakkaat korrelaatiot käytön kanssa. Äidin terveysuskomukset näyttivät olevan hiukan voimakkaammin yhteydessä nuorten ruokatottumuksiin kuin isien tai nuorten itsensä terveysuskomukset.
Paternalismi ja suomalainen tupakkapolitiikka
Authors: Häyry Heta , Häyry Matti , Karjalainen Sakari
Published: January 2025

Paternalismi on yksi kansanterveystyön ja sairauksien laajamittaisen ennaltaehkäisyn monimutkaisimmista eettisistä ongelmista. Artikkelissa pyritään valaisemaan asiaan liittyviä pulmakysymyksiä tarkastelemalla toisaalta paternalismiin eli holhoukseen liittyviä teoreettisia ulottuvuuksia ja toisaalta maassamme ehdotettuja ja käytössä olevia tupakoinnin terveyshaittojen rajoittamiseen tähtääviä säädöksiä ja toimenpiteitä.
Ihomelanooman vaaratekijät Suomessa
Authors: Nummenmaa Juho , Ruohonen Leena , Röntynen Leena
Published: January 2025

Tutkimuksen tavoitteena oli selvittää melanooman ilmaantuvuuden lisääntymisen syitä tapaus-verrokki-asetelmaan perustuen. Potilaat olivat Helsingin ja Tampereen yliopistollisten keskussairaaloiden melanoomapotilaita, jotka oli hoidettu vuosina 1979-1984. Verrokit olivat iän, sukupuolen ja asuinkunnan mukaan kaltaistettuja väestörekisteristä poimittuja verrokkeja. Potilaille ja verrokeille lähetettiin postitse kyselylomake, jossa erityisesti pyrittiin kartoittamaan auringonottotottumuksia sekä vastaajan tekemät ns. aurinkorannoille suuntautuneet matkat. Tapaus-verrokkipareja muodostui 133.
Tutkimuksen mukaan melanoomapotilaille yhteisiä piirteitä olivat vaaleaihoisuus, huonosti ruskettuminen ja helposti palaminen. He myös ottivat aurinkoa ja polttivat ihonsa useammin kuin verrokit. Ilmaantuvuuden suurenemista selittäviä tekijöitä ei kyetty tunnistamaan.
Prevention etiikka
Authors: Lindqvist Martti
Published: January 2025

Modernin terveydenhuollon piirissä terveyskasvatuksen ja sairauden ennaltaehkäisyn oikeutusta on useimmiten pidetty itsestäänselvyytenä. Niiden on katsottu kiistatta palvelevan sekä yksilön että yhteiskunnan etua. Vasta tällä vuosikymmenellä maassamme on virinnyt laajempaa keskustelua sairauksien ehkäisyn etiikasta.
Ennaltaehkäisyn oikeutuksesta on eettiseltä kannalta vaikea sanoa mitään yleistettävää, koska kysymys ratkeaa pitkälti sen pohjalta, millaisin motiivein ennaltaehkäisyä harjoitetaan, millaisia keinoja siinä käytetään, mihin tarkoituksiin sitä sovelletaan ja miten sillä mahdollisesti saavutettavat arvot suhteutetaan muihin arvoihin. Filosofisesti kysymys koskee myös sitä, kuinka pitkälle on oikeus puuttua yksilön oikeuksiin.
Terveys on sekä välinearvo että itseisarvo monien muiden joukossa. Moralisoiva terveyskasvatus on sekä epätarkoituksenmukaista että yksilöä loukkaavaa. Vaarana on myös se, että ennaltaehkäisyn alueella terveydenhuolto alkaa tukea sellaisia yhteiskunnallisia, taloudellisia ja ideologisia intressejä, jotka eivät ole sopusoinnussa lääketieteen etiikan perinteiden eikä ihmisoikeuksien kanssa. Eettisesti perusteltu ennaltaehkäisy tähtää kansalaisten tiedon lisäämiseen, suojautumisen ulkopuolisilta riskeiltä sekä heidän mahdollisuuksiensa lisäämiseen oman elämän hallintaan.
Työssäkäyvän kaupunkiväestön nukkumistottumukset, unen laatu ja unihäiriöt
Authors: Urponen Helka , Vuori Ilkka , Hasan Joel , Partinen Markku
Published: January 2025

Tutkimuksessa selvitettiin työssäkäyvän kaupunkiväestön (N=1190) nukkumistottumuksia, unen määrää ja laatua sekä niihin yhteydessä olevia yksilötasoisia tekijöitä. Tutkimus tehtiin postikyselyllä, ja vastausprosentti oli 75.
Hyvin ja huonosti nukkuvat määriteltiin uni-indeksillä, jossa otettiin huomioon useat unen laadun häiriöt sekä niiden esiintymistaajuudet. Huonounisuuteen olivat selvimmin yhteydessä naissukupuoli, ikäryhmän karttuminen ja huonoksi koettu terveys. Huonosti nukkuvia oli miehistä 6 % ja naisista 12 %. Huonounisuuden tunnuspiirteet näkyivät erityisesti naisilla. Huonosti nukkuvia naisia oli keskimääräistä useammin 50-vuotiaiden, naimattomien ja leskien, terveyttään huonoksi kokevien, hyvin koulutettujen ja hyvissä sosioekonomisissa asemissa elävien sekä toisaalta myös vuorotyötä tekevien naisten keskuudessa. Elintavat eivät olleet yhteydessä huonounisuuteen.
Tulokset osoittivat, että monet psykososiaaliseen taustaan, elämäntilanteeseen ja niiden määrittämiin rooleihin liittyvät tekijät ja toisaalta terveydelliset ongelmat vaikuttavat nukkumiseen ja unen laatuun.
Analysis of Employee Management in Improving The Performance of Shipping Service Companies
Authors: Reni Agus Tamrin
Published: January 2025

This research investigates the influence of human resource management (HRM) and job satisfaction on business performance, using employee productivity as a mediating variable. The research used a quantitative survey targeting Shopee Xpress Sekupang Branch employees. A structured questionnaire was distributed to 116 respondents, selected through purposive sampling, to measure HRM, Job Satisfaction, Employee Productivity, and Business Performance. Data analysis was set utilizing SmartPLS to test the proposed hypotheses. The outcomes reveal that HRM and Job Satisfaction significantly favorably affect Employee Productivity and Business Performance, both directly and indirectly. Notably, Employee Productivity mediates the connection between HRM and Business Performance and between Job Satisfaction and Business Performance. These outcomes emphasize the critical role of effective employee management in enhancing organizational outcomes. The research highlights the importance of improving HR strategies to address operational inefficiencies and enhance service quality. Recommendations are provided for optimizing HR practices to foster a more productive and satisfied workforce, ultimately boosting business performance.
A Study of Islamic Moderation Discourse Among Female Scholars in Banyumas Regency Based on Their Interpretation of Radical-Indicating Hadiths
Authors: Munawir Munawir , Liddini Laily , Arjuna Klawing
Published: January 2025

Islamic radicalism in Indonesia has evolved from merely an ideology to a full-blown terrorist movement. In the context of the spread of Islamic radicalism in Indonesia, Banyumas Regency is categorized as a yellow zone, signifying it is under surveillance by Densus 88 and BNPT. Islamic radicalism is triggered by numerous factors, with one of the primary causes being a textualistic and non-comprehensive understanding of religious texts, including hadith. Particularly problematic are hadith with radical connotations. Islamic scholars play a crucial role in deradicalization discourse. Traditionally, Islamic scholars have been associated with the male gender; however, there are now many female scholars whose Islamic thought contributes significantly and is accessible to the public, including female scholars in Banyumas Regency. Through fieldwork involving observation, interviews, and document analysis, and subsequent data analysis using theories of textualist and contextualist understanding and Islamic moderation, it was found that female scholars in Banyumas Regency interpret hadith with radical connotations contextually and possess moderate Islamic thought and practices.
Waqf in History a Systematic Literature Review based on Web of Science
Authors: Quddus Muhammad Fathrul
Published: January 2025

Waqf in history is an interesting topic to discuss. By knowing the history related to waqf, a Muslim can develop broader perceptions of waqf. This study aims to determine the roles of waqf in the past to be studied and furthermore it is hoped that it can be a recommendation in managing waqf both in terms of managers and regulators. The method used in this study is a systematic literature review. The data used are articles on the Web of Science (WoS). WoS is the oldest, most widely used, and authoritative database of research publications and citations in the world. The topic keywords used in the search were “Waqf in History”, “Waqf Histories”, and “Waqf and Centuries”. The author selected 23 articles that had been screened with inclusion and exclusion criteria. Furthermore, the author divides the 23 articles into 4 major topics, namely: the role of waqf, accounting and waqf supervision, waqf regulations and rules, and waqf risks.
Modernization of Islamic Education in Bibliometric Review
Authors: Asari Hasan , Ritonga Maisaroh , Nursalimah Nursalimah , Megawati Betti , Ruwaidah Ruwaidah
Published: January 2025

In recent years, calls for the modernization of Islamic education have expanded their focus beyond the levels of basic and secondary education to include Islamic university institutions. Studies on Islamic education are particularly noteworthy when presented in the form of bibliometric analysis. The purpose of this study is to create a map of research trends in bibliometrics that pertain to the process of modernizing Islamic education. This research, which relies on data, examines the number of articles on modernizing Islamic education that have been published in various countries throughout the world. The Dimensions database was used in the study dataset, which was then analyzed using Bibliometrix utilizing R-Tool and displayed with Vosviewer. The findings of the bibliometric mapping of research on modernizing Islamic education using Biblioshiny and VOSviewer yielded 197 relevant articles in 160 journals between 1965 and 2022. Mukhibat, Hidayatulla Azra, and La Hadisi were the top three authors on this topic. The majority of research trends, as illustrated by the visualization of data from VOSviewer, are associated with Islamic Education. The phrases "Indonesia," "Turkey," and "Egypt" Egypt are included in this picture, which gives the impression that the majority of research on topics linked with the modernization of Islamic Education is carried out in these three nations.
Evaluation and treatment of lead toxicosis in rehabilitated avian species: 95 cases (2014–2023)
Authors: Elliott Stephanie A. , Hawkins Shawna , Lemley Erin , McCormick Logan , Mans Christoph
Published: January 2025

OBJECTIVE

To evaluate avian patients presented to a wildlife rehabilitation facility with confirmed lead toxicity for clinical signs associated with blood lead level groups, efficacy of subcutaneous chelation therapy with calcium disodium EDTA, and case outcome based on presenting blood lead levels.

METHODS

A retrospective record review of 95 avian cases representing 19 species treated for lead toxicosis from a wildlife rehabilitation center in Wisconsin between 2014 and 2023 was conducted. Data were evaluated for presenting complaints, clinical signs, radiographic findings, chelation therapy protocol, clinical pathology data, and case outcome.

RESULTS

A low lead level of < 20 µg/dL was the most commonly diagnosed level in avian patients. The presence of neurologic disease was found most commonly in birds with higher blood lead levels, whereas poor body condition, trauma, and anemia were most common in birds with low lead levels. Bald eagles (Haliaeetus leucocephalus) and tundra swans (Cygnus columbianus) were the most prevalent species presented. All methods of chelation therapy evaluated resulted in a reduction of blood lead levels. Patients with intake blood lead levels > 60 µg/dL were more likely to die or be euthanized while in care.

CONCLUSIONS

A bird with a blood lead level > 60 µg/dL is more likely to present with neurologic disease and have a poor case outcome. Diluted calcium disodium EDTA was clinically effective when administered SC.

CLINICAL RELEVANCE

Initial blood lead level, in conjunction with species, clinical signs, and radiographic changes, can help guide clinical decision-making for avian patients with lead toxicosis.
Outcomes associated with local treatment of nasal planum squamous cell carcinoma in dogs: 89 cases (2003–2020)
Authors: Raleigh Joseph S. , Culp William T. N. , Giuffrida Michelle A. , Thomson Chris , Martin Tiffany , Mathews Kyle G. , Skinner Owen , Leonardi Abby , Bertran Judith , Selmic Laura E. , Dornbusch Josephine , Wilson Jordan , Oblak Michelle , Fransson Boel , Lux Cassie N. , Wustefeld-Janssens Brandan , Hollenbeck Danielle , Liptak Julius M. , Phillips Heidi , Selting Kim A. , Park Ji Eun , Wallace Mandy , Steffey Michele A. , Balsa Ingrid M. , Mayhew Philipp D. , Rebhun Robert B. , Kent Michael S.
Published: January 2025

OBJECTIVE

To describe the clinical characteristics, treatments, complications, and outcomes in dogs with nasal planum squamous cell carcinoma (SCC) undergoing local treatment.

METHODS

A retrospective, multi-institutional study was performed. Medical records were searched to identify dogs diagnosed with nasal planum SCC. Variables were recorded from medical records and statistically analyzed.

RESULTS

89 dogs were included. The most common presenting complaint was a visible mass on the nasal planum (89%). Metastasis was detected in 12% of dogs at the time of local therapy. Local therapy consisted of surgical excision alone in 63 of 89 dogs (71%) and radiation therapy alone in 20 of 89 dogs (22%); 6 dogs had multiple local therapies. Tumor size decreased in 12 dogs (60%) undergoing radiation therapy alone. Local recurrence was reported in 19 of 89 dogs (21%), including 16 of 63 dogs (25%) treated with surgery alone. Median survival time of all dogs was 452 days (95% CI, 285 to 576). Median survival time among 33 dogs with documented disease progression was 336 days (95% CI, 189 to 458), versus 685 days (95% CI, 334 to 1,042) in 56 dogs that did not have documented disease progression, which was significantly different (P = .038). Documented disease progression was significantly associated with hazard of death (hazard ratio, 1.93; 95% CI, 1.03 to 3.63; P = .041).

CONCLUSIONS

Dogs undergoing local treatment of nasal planum SCC had a favorable prognosis. Metastasis at the time of treatment was uncommon. Long-term survival was possible, particularly in cases without disease progression.

CLINICAL RELEVANCE

Aggressive local therapy, particularly surgical resection, should be considered in dogs with nasal planum SCC.
Postoperative prophylactic antibiotics were not associated with decreased surgical site infections following hemilaminectomy in dogs: a retrospective study
Authors: Jaramillo Ericka L. , Frederick Steven W. , Israel Sarah K.
Published: January 2025

OBJECTIVE

To compare hemilaminectomy surgical site infection (SSI) rates in dogs treated with or without postoperative prophylactic antibiotics.

METHODS

Medical records of 275 client-owned dogs from 1 tertiary referral hospital were retrospectively reviewed for dogs treated with thoracolumbar hemilaminectomy for intervertebral disk herniation between 2018 and 2023. Dogs were grouped according to whether they were treated with prophylactic postoperative antibiotics (group A) or not (group B). Relevant case details including dog signalment, duration of anesthetic procedure, method of incision closure, perioperative and prophylactic postoperative antibiotic prescription, and diagnosis of postoperative SSI (as defined by the CDC) were recorded. Wilson binomial CIs were calculated for SSI rates. Surgical site infection rates between dogs given or not given antibiotics were analyzed with a Fisher exact test.

RESULTS

The overall SSI rate was 3% (8 of 275; 95% CI, 1% to 6%). The SSI rate in group A was 3% (5 of 147; 95% CI, 1% to 8%), which was not statistically different from the 2% SSI rate (3 of 128; 95% CI, 1% to 7%) in group B (P = .728). There was not a statistical difference in SSI rates between closure methods (intradermal absorbable, 1% [1 of 79]; cutaneous staples, 4% [7 of 184]; cutaneous nylon, 0% [0 of 12]; P = .611).

CONCLUSIONS

Overall hemilaminectomy SSI rates in this study were low, and prescription of prophylactic antibiotics was not associated with a decreased SSI rate.

CLINICAL RELEVANCE

Practicing antimicrobial stewardship through avoidance of antimicrobial prophylaxis in clean surgical procedures may not be clinically detrimental to outcomes in hemilaminectomy dogs.
The Use of Technological Innovations in the Field From The Perspective of Rural Producers in Goiás
Authors: Pereira Ivone Vieira , Magalhaes Joice Carolina Sousa , Freitas Leninne Guimaraes , Furnieles Claudemir Bertuolo
Published: January 2025

Objective: The objective of this study was to identify the technological innovations used in the field by rural producers in Goiás. Responsible for giving an impulse to agribusiness, Agro 4.0, also known as digital agriculture, goes beyond the simple mechanization of the countryside.
 
Theoretical picture: The operations and decisions take into variable considerations such as the climate, land and crop from which data collected by digital technologies is taken in real time. The use of technological innovations is transforming agribusiness in a surprising way, and is growing increasingly more among rural producers.
 
Method: The research has a qualitative nature, classified as exploratory, the collection of data was carried out through the application of a questionnaire. The data analysis was carried out in a descriptive manner.
 
Results and discussion: The results obtained made it possible to identify that 82.69% of the participating producers use some kind of technological innovation, and that 69.23% use some kind of on-board technology. Through the collected data it is possible to observe that the main technologies used by the participants in this study are GPS, drones and management software.
 
Implications of the research: The rural producers from Goiás make use of on-board technology.
 
Originality and value: The relevance of this research is to demonstrate what technological innovations the rural producers in Goiás are using in the field in order to emphasize its applicability by demonstrating the benefits and challenges in agro 4.0. This study seeks to offer significant contributions not only to academia, but also to professionals active in the market, fostering a deeper understanding of the advantages and usability of technological innovations in the field.
#031 Restaurações estéticas em dentes anteriores – Uma opção conservadora
Authors:   Egas Moniz School of Health & Science, Egas Moniz School of Health % 26 Science, Nunes Mariana , Amorim Tomás ,   Egas Moniz School of Health & Science, Egas Moniz School of Health % 26 Science
Published: January 2025

Introdução: Com o aumento da procura por procedimentos estéticos na área da dentisteria, há cada vez mais a necessidade de melhorar a sua resposta, por meio de materiais e técnicas que otimizem a qualidade, o tempo
despendido e a biomimetização das estruturas. As restaurações diretas em resina composta como recurso a reabilitações estéticas, resultam em procedimentos minimamente invasivos e conservadores. Descrição do Caso Clínico:
Este caso clínico relata um paciente do género masculino,
de 36 anos, saudável, que compareceu à consulta de triagem
na Clínica Dentária Universitária Egas Moniz, demonstrando o interesse em alterar a estética do seu sorriso. Foi realizado um plano de tratamento multidisciplinar, tendo
como foco a melhoria da estética dos dentes anteriores, já
que apresentavam alterações de forma, tamanho e cor. Sendo assim, foram propostas restaurações diretas em resina
composta nos dentes #12, #11, #21 e #22, através de um enceramento de diagnóstico e da confeção de uma chave palatina. Discussão e Conclusões: As resinas compostas apresentam diversas vantagens já que têm facilidade na sua
utilização, um número de intervenções menores, boa adesão à estrutura dentária e uma grande variedade dos materiais disponíveis. Para além disto, conseguem ser minimamente invasivas, tendo um baixo custo para o paciente e
um alto desempenho clínico. Com foco no biomimetismo,
as resinas funcionam bem em restaurações estéticas por
serem usadas de forma direta e conservadora, visando as
propriedades óticas e estruturais do dente. Contudo, com o
desenvolvimento de resinas estéticas, exige um maior esforço por parte do clínico, devido às estratégias de estratificação hoje implementadas. Para a realização de restaurações estéticas, ao confeccionar uma matriz com um
silicone, sobre um enceramento de diagnóstico previamente realizado, não só permite a criação da chave palatina,
como também a visualização para o clínico e para o paciente do trabalho pretendido. Ao usar uma chave palatina, cria-
-se uma guia de trabalho do clínico facilitando a estratificação das resinas e reduzindo o tempo de trabalho. Deste
modo, foi possível corresponder às expectativas do paciente executando um tratamento conservador e económico.
Apesar da existência de novas técnicas, as restaurações
estéticas continuam a ser uma boa opção de tratamento.
Analisis Pengelolaan Sumber Daya Manusia dan Layanan Khusus di SDIT Al Ibrohimi
Authors: Ayyubi Fahmi Al , Wulandari Ayu , Afnani Anas , Kafi Nurul , Wicaksono Daniel
Published: January 2025

Penelitian ini menganalisis pengelolaan sumber daya manusia (SDM) dan layanan khusus di SDIT Al Ibrohimi untuk meningkatkan efektivitas pendidikan terpadu. Fokus utama dari penelitian ini adalah untuk memahami bagaimana strategi pengelolaan SDM dan penyediaan layanan khusus dapat berkontribusi pada kualitas pembelajaran serta kesejahteraan siswa. Metode penelitian yang digunakan adalah pendekatan kualitatif dengan wawancara mendalam dan observasi langsung terhadap tenaga kependidikan dan siswa di SDIT Al Ibrohimi. Hasil penelitian menunjukkan bahwa pengelolaan SDM yang efektif, termasuk peningkatan kompetensi guru dan dukungan administratif yang kuat, berperan signifikan dalam menciptakan lingkungan belajar yang optimal. Selain itu, layanan khusus seperti konseling, bimbingan akademik, dan pengembangan karakter berkontribusi besar dalam memenuhi kebutuhan individual siswa. Penelitian ini merekomendasikan peningkatan manajemen SDM serta penguatan layanan khusus untuk mendukung visi pendidikan terpadu di SDIT
Peningkatan Kreativitas Bernilai Ekonomi Pada Komunitas Perempuan Hebat Sumenep Melalui Pelatihan Kerajinan Tangan Merajut
Authors: , Isyanto , Yuliastina Roos , Hidayat Imam
Published: January 2025

Mitra PKM ini adalah Komunitas Perempuan Hebat Sumenep atau disingkat dengan istilah KPHS. Komunitas ini terbentuk pada tahun 2021, dan pada tanggal 04 April tahun 2022 telah resmi menjadi lembaga swadaya masyarakat legal berdasarkan akta notaris Naghfir, S.Hi, S.H, M.H. Jumlah Anggota KPHS sampai saat ini sebanyak 75 orang, dimana seluruh anggota yang bergabung dalam KPHS adalah perempuan dengan status janda. Peran sebagai single parent atau perempuan kepala keluarga memberi beban tersendiri bagi perempuan pasca perceraian. Posisi sebagai perempuan kepala keluarga menuntut perempuan – perempuan pacsa perceraian menanggung peran ganda, yaitu sebagai kepala keluarga dan sekaligus sebagai ibu rumah tangga. Hal ini terjadi karena baik perempuan janda cerai atau ditinggal mati dituntut mampu mengkombinasikan secara baik antara pekerjaan domestik dan publik, seperti  harus mencari uang untuk menafkahi keluarganya dan juga harus memenuhi kebutuhan kasih sayang keluarganya (anak-anaknya). Fenomen ini yang menjadi dasar kegiatan PKM ini dilakukan, tujuan dari kegiatan PKM ini adalah memberikan peluang bagi komunitas perempuan (status janda) untuk dapat meningkatkan kreativitas sehingga membuka peluang usaha rumah tangga untuk meningkatkan pendapatan melalui pelatihan kerajinan tangan merajut.  Luaran kegiatan ini dibagi menjadi tiga aspek, (1) luaran secara akademik berupa publikasi jurnal PKM ber ESSN,  (2) poster kegiatan PKM dan video kegiatan PKM, dan yang terakhir tercapainya target keterampilan mitra PKM melalui kegiatan merajut
SPATHODEA CAMPANULATA EXTRACT ATTENUATES ACETAMINOPHEN-INDUCED HEPATIC INJURY IN MICE
Authors: Dadzeasah Phyllis Elsie , Ansah Charles
Published: January 2025

Spathodea campanulata, well known for its traditional medicinal uses was investigated for hepatoprotective activity against acetaminophen-induced hepatic damage in mice. Six groups of mice were pre-treated with 100, 300 and 625 mg/kg of the aqueous extract of Spathodea campanulata stem bark, N-acetyl cysteine (300 mg/kg; p.o) or distilled water for 5 days before they were intoxicated with a single dose of acetaminophen (600 mg/kg; p.o). Alanine aminotransferase, Aspartate aminotransferase and total protein levels were measured in serum, glutathione peroxidase, superoxide dismutase and total cytochrome P450 levels were measured in liver homogenate and liver histology was also observed on liver sections. Total liver cytochrome P450 levels in Spathodea campanulata extract, distilled water, ketoconazole or phenobarbital-treated animals were also measured. Significant hepatoprotection was obtained against liver damage induced by acetaminophen as evident from decreased serum levels of Aspartate transaminase, Alanine transaminase and increased levels of total protein in the combined acetaminophen and extract treated groups and the acetaminophen and N-acetylcysteine-treated groups compared to the acetaminophen only controls. The decrease in serum antioxidant enzymes; glutathione peroxidase and superoxide dismutase levels caused by acetaminophen was significantly reversed by the extract. The results correlated well with the histopathology of liver from treated and control animals. The extract also caused considerable inhibition of total CYP450, the enzymes involved in the activation of acetaminophen. The present results indicate that Spathodea campanulata protects the liver against acetaminophen-induced hepatotoxicity by enhancing antioxidant protection capacity and interfering with the bio-activation of acetaminophen.
ACUTE TOXICITY AND EVALUATION OF THE ANTINOCICEPTIVE ACTIVITY OF AMANOA ALMERINDAE LEAF AQUEOUS EXTRACT IN EXPERIMENTAL ANIMALS
Authors: Torrico F. , Cedeño P. , Guevara A. , Compagnone R. S. , Suárez A. I.
Published: January 2025

The aim of the present study was to evaluate the antinociceptive activity and toxicity of an aqueous extract obtained from leaves of Amanoa almerindae. Abdominal constriction, formalin and tail flick test were use to determine the antinociceptive properties of the extract. The extract was administered both orally and using intraperitoneal injections. The results indicate that this aqueous extract exhibit dose dependent antinociceptive activity when tested by the different methods. Moderate toxicity was more evident following intraperitoneal administration. This confirms that oral administration is safer and should be performed when evaluating natural products as proposed by OMS/TMR (2002). In spite of toxicity signs shown by intraperitoneal/oral administration, there was no evident direct tissue damage (toxicity). The analgesic activity of the drug seems to affect both the peripheral and central nervous system. Therefore, it is important to ascertain the metabolites responsible for these actions in the phytochemical screening.
BIOEQUIVALENCE STUDY OF TRAMADOL + PARACETAMOL (37.5 + 325 MG) IN HEALTHY HUMAN VOLUNTEERS IN FASTING CONDITION
Authors: Dhanure S. , Savalia A. , Nayak S. K. , Das A. K. , Kotha S. K. , Patra A. K.
Published: January 2025

The bioequivalence between test and reference Tramadol and Paracetamol (37.5 + 325 mg) tablets was determined in 36 healthy subjects after a single dose in a randomized crossover study under fasting condition. Plasma concentrations were monitored over a period of 24 hour after the drug administration by validated LC/MS/MS analytical method. The pharmacokinetic parameters Cmax, AUC0-t, AUC0-∞, AUC0-t / AUC0-∞, Tmax, Kel and t½ were determined from plasma concentration time profile of both formulations and found to be acceptable. The calculated pharmacokinetic parameters were compared statistically to evaluate bioequivalence between the test and reference products. The analysis of variance did not show any significant difference between the two formulations and 90 % confidence intervals for the ratio of Cmax (92.29 -104.18 %), AUC0-t (99.52 - 104.11 %) and AUC0-∞ (99.05 - 104.22 %) for tramadol and Cmax (93.56 - 110.27 %), AUC0-t (96.37 - 102.70 %) and AUC0-∞ (97.22-103.28 %) for paracetamol test and reference products were within the 80 – 125 % interval, satisfying the bioequivalence criteria the US Food and Drug Administration Guidelines. These results indicate that the test and the reference products of Tramadol and Paracetamol are bioequivalent.
POLYOX (POLYETHYLENE OXIDE) MULTIFUNCTIONAL POLYMER IN NOVEL DRUG DELIVERY SYSTEM
Authors: Shah Kinjal R. , Chaudhary Sunita A. , Mehta Tejal A.
Published: January 2025

Polymers are tools used in novel drug delivery system to modify the drug release of pharmaceutical dosage form. Polyox is hydrophilic polymer made of non-ionic homopolymer of ethylene oxide. Polyox is popular for its film forming, binding, lubricating, mucoadhesive, viscosity imparting property in pharmaceuticals. Polyox are available in various grades based on its molecular weight. Lower molecular weight Polyox are widely used for immediate drug release based on erosion properties of the polymer like quick dissolving film and high molecular weight Polyox are used to retard the drug release based on swelling and erosion properties of the polymer in controlled release, sustained release, extended release, buccal films, ocular inserts, ocular gels, osmotic tablets and so on. Polyox plays an important role in design of a novel drug delivery system for both highly and poorly soluble drug due to its multifunctional property. This review is detailed on Polyox its advantages, disadvantages, salient feature, mechanism, stability and application in pharmaceutical dosage form.
FORMULATION AND EVALUATION OF MUCOADHESIVE MICROSPHERES OF LAMIVUDINE
Authors: Parveen Aliya , Syed Iizhar Ahmed
Published: January 2025

The aim of the present work was to prepare and evaluate mucoadhesive microspheres of Lamivudine. Microspheres were formulated using sodium alginate (5%) with mucoadhesive polymer (Chitosan 1%) and copolymer Sodium CMC HPMC, Xanthan gum (XG) in concentration of 1% (Chitosan1% + HPMC1%) (1%) retarding agents and 10% of Calcium chloride (CaCl2), Aluminum sulphate (AlSO4) as cross linking agents by employing Ionic Gelation Technique. The particle size was characterized for by scanning electron microscopy (SEM) and drug excipients compatibility was determined by FT-IR spectroscopy. Percentage drug content, Entrapment efficiency and in-vitro dissolution studies were also carried out. Among the prepared microspheres (F8) formulation in which AlSO4 was used as cross linking agent, portray better sustained release for more than 12hrs. The dissolution profile followed the near zero order profile and Hixon-crowell as “best fit” model. SEM shows that prepared microspheres were of spherical in shape and free flowing. FT-IR results showed compatibility of Lamivudine with excipients used.
SYNTHESIS, ANTIMICROBIAL AND ANTI-INFLAMMATORY ACTIVITY OF NEWLY SYNTHESIZED ISOXAZOLINE INCORPORATED 2-QUINOLONES
Authors: Kumar Abhishek , Fernandes Jennifer , Kumar Pankaj
Published: January 2025

A series of novel substituted 1-amino-3-(5-phenyl-4,5-dihydroisoxazol-3-yl) quinolin-2(1H)-one (AJI1-AJI8) have been synthesized upon reaction with 1-amino-3-cinnamoyl-quinolin-2(1H)-one by using hydroxylamine hydrochloride as cyclising agent in alcohol medium. The intermediate chalcones 1-amino-3-cinnamoyl-quinolin-2(1H)-one (AJC1-AJC8) were synthesized by condensing 3-acetyl-1-amino-quinolin-2-one with different substituted benzaldehyde in presence of 40% ethanolic KOH. The title compounds obtained were characterized by IR, 1H NMR, mass spectra and elemental analysis. The synthesized compounds were screened for their antimicrobial and anti-inflammatory activity.
SIMULTANEOUS DETERMINATION OF CLOBETASOL (AS PROPIONATE) AND CHLOROCRESOL IN CREAM BY STABILITY INDICATING RP-HPLC METHOD
Authors: Turabi Zahi Mohammad , Khatatbeh O’hood Atef
Published: January 2025

A stability-indicating reverse phase-HPLC method has been developed and validated for the simultaneous determination of Clobetasol propionate (CLOB) and Chlorocresol (CHLOR) in pharmaceutical dosage form (cream). Beclomethasone dipropionate monohydrate (BEC) was used as internal standard. The column (Luna) C18 (250 mm × 4.6 mm, 5μm particle size) was used for chromatographic separation. The gradient elution system was performed using mobile phase A: Ammonium dihydrogen phosphate pH 4.5 and methanol in the ratio of 80:30 respectively, and Acetonitrile as mobile phase B. The flow rate was adjusted to 1.5 ml/min. The column oven was set at 25°C and the detection wavelength at 240nm. The retention times of CHLOR, CLOB and BEC were found to be 8.86 min, 13.36 min and 15.6 min respectively. The linearity was performed in the concentration ranges of 64.0-96.0μg/ml (CHLOR), 32.0-48.0μg/ml (CLOB), and 80μg/ml (BEC) with squared correlation coefficient of 0.9995 and 0.9996 for CHLOR and CLOB respectively. The percentage purity of CHLOR and CLOB was found to be > 99.5 %. The analytical method has been validated for specificity, linearity, precision, accuracy, ruggedness and robustness which were found to be within the acceptance limit according to ICH guidelines. The developed method was successfully employed for routine and stability analysis of CHLOR and CLOB in pharmaceutical cream.
STABILITY-INDICATING RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR THE DETERMINATION OF ROSUVASTATIN (CALCIUM) IN PHARMACEUTICAL DOSAGE FORM
Authors: Turabi Zahi Mohammad , Khatatbeh O’hood Atef
Published: January 2025

A stability indicating, accurate, specific, linear and sensitive reverse phase-HPLC method has been developed and validated for the determination of Rosuvastatin as calcium, (ROS) in pharmaceutical dosage form. The chromatographic separation was performed using end capped (Luna) C18 Column (250 mm × 4.6 mm, 5μm particle size). Mobile phase A was prepared by mixing 3.0g/l Ammonium dihydrogen phosphate in distilled water: Methanol: Acetonitrile: Tetrahydrofuran in the ratios (400:20:100:5v/v). To 1000 ml of the resulting solution 1 ml of triethylamine was added then the pH was adjusted to 6.3 with 5% v/v orthophosphoric acid. Mobile phase B was prepared by mixing Acetonitrile: Methanol: Tetrahydrofuran in the ratios (500:50:5v/v). Other chromatographic conditions such as flow rate set at 2.0 ml/min and 30°C column temperature with the detection wavelength at 243nm. The retention times of Rosuvastatin was found to be about 16 min. The linearity was performed in the concentration range of 40.0-60.0μg/ml with a squared correlation coefficient of 0.99998. The percentage purity of ROS was found to be >99.8%. The percentage recovery was determined for ROS and was found to be 100.067%. The developed analytical method has been validated for specificity, linearity, precision, accuracy, ruggedness and robustness which were within the acceptance limit according to ICH guidelines. All the degradation products obtained by stress conditions were found to be well separated from the principal peak, which means that the ROS peaks were highly pure in all chromatograms obtained. The developed method was successfully employed for routine quality control and stability analysis of ROS in pharmaceutical dosage forms.
ANTIOXIDANT ACTIVITY OF COMPOUNDS ISOLATED FROM THE ROOT WOODS OF ERYTHRINA DROOGMANSIANA
Authors: Yaya AJG , Feumba RD , Emmanuel T , Tchinda AT , Fredérich M , Oben J , Mbafor JT
Published: January 2025

The aim of this study was to isolate, to characterize secondary metabolites from methanolic extract of the root woods of Erythrina droogmansiana and to assess the antioxidant activity of the crude extract and isolated compounds. The phytochemical study led to the isolation of 3-(3’,4’-methelenedioxyphenyl)-2,3-epoxypropanol (1), asperphenamate (2) and three flavonoids namely genistein, diadzein and 4’,5,7-trihydroxy-8-prenylisoflavone. These compounds were characterized using their 1H NMR, 13C NMR, HMBC, HSQC, COSY, mass spectral and the literature. To evaluate antioxidant activity of crude extract and isolated compounds, the radical scavenging (DPPH) and Ferric Reducing Ability Power (FRAP) were performed using ascorbic acid as standard. Compounds 1 and 2 showed moderate radical scavenging potential with IC50 value of 3.14 and 3.31 mg/ml respectively, and moderate reducing power ability with value of 0.14±0.01 mgAAE/mg and 0.21±0.01 mgAAE/mg respectively. The more active compound was genistein (3) with IC50 value of 1.96 mg/ml for the DPPH radical scavenging potential and 0.24±0.02 mgAAE/mg for its ability to reduce iron.
FORMULATION, OPTIMIZATION AND IN VITRO CHARACTERIZATION OF LETROZOLE LOADED SOLID LIPID NANOPARTICLES
Authors: Nerella Archana , D Basava Raju , M Aruna Devi
Published: January 2025

Letrozole (LTZ) is an oral non-steroidal aromatase inhibitor for the treatment of hormonally responsive breast cancer after surgery. The objective of the current study is to prepare and evaluate Solid lipid nanoparticles (SLN) of LTZ. SLNs were prepared by hot homogenization followed by ultrasonication. Trimyristin was used as solid lipid core, Soyphosphatidyl choline, Tween 80 as surfactant mixture. Process and formulation variables were studied and optimized. LTZ-SLN were characterized for mean particle size, polydispersity index (PDI) and zeta potential for all the formulations. The mean particles size, PDI, zeta potential and entrapment efficiency of optimized LTZ-SLN optimized formulation was found to be 28.54 nm, 0.162, 11.80 mV, 85.64 %, respectively. In vitro release profiles are performed in 0.1N HCl using modified franz diffusion cell showed controlled drug release behavior over a period of 24h. LTZ-SLN formulations are subjected to stability study over a period of 1 month in terms of particle size, zeta potential, PDI, entrapment efficiency and are found to be stable. Differential scanning calorimetry (DSC) and transmission electron microscopy (TEM) analysis was performed to characterize the state of drug, lipid modification, shape and surface morphology of prepared LTZ-SLN formulations.