bluuebunny/crossref_metadata_2025 huggingface dataset:
Expression of retinoid nuclear receptor superfamily members in human hair follicles and its implication in hair growth.
Authors: Billoni N , Gautier B , Mahé YF , Bernard BA.
Published: June 2023

Since clinical evidence of hair loss and hair depigmentation following etretinate therapy has been reported, we decided to study the expression levels of several members of the retinoid nuclear receptor superfamily in dermal and epithelial compartments of the human hair follicle. Additionally, we evaluated the effects of several ligands for these receptors on human hair growth in culture in vitro. We observed that the cellular/ cytoplasmic retinoic acid (RA) binding protein-II and the retinoid-X-receptor-alpha were constantly and strongly expressed in both compartments at levels comparable to those of vitamin D receptor. In dermal papilla cells, by contrast with RAR beta which was always expressed, RAR alpha and RAR gamma were not constantly expressed. In dermal sheath fibroblasts, both RAR alpha, RAR beta and RAR gamma mRNAs were moderately expressed, while in the epithelial compartment, namely the plucked hair, we observed the expression of the same genes in the absence of RAR beta. We also observed that RAR agonists all-trans RA and CD367 inhibited the survival of human hair follicles in culture in vitro, while RXR agonist CD2425 stimulated hair growth and survival at levels comparable to those of 1 alpha,25-dihydroxyvitamin D3, suggesting that RXR agonists might stimulate hair growth in humans in vivo.
Acute cutaneous barrier perturbation induces maturation of Langerhans' cells in hairless mice.
Authors: Katoh N , Hirano S , Kishimoto S , Yasuno H.
Published: June 2023

Perturbation of the cutaneous water permeability barrier has been shown to result in many physiological events in keratinocytes, including upregulation of proinflammatory cytokine production. However, little is known about the effect of barrier disruption on Langerhans' cells (LC). In the present study, we examined whether acute barrier perturbation by acetone treatment or tape stripping affects the phenotypes and functions of LC in male hairless mice. Both procedures resulted in a two- to five-fold increase in the expression of MHC class II antigens, B7-2 and intercellular adhesion molecule-1 on LC, whereas no significant changes were detected in levels of B7-1. Levels of intracellular interleukin-1 beta, as determined by flowcytometry, were also increased 1 h after acetone treatment or tape stripping. LC obtained from barrier-disrupted mice induced a significant increase in syngeneic and allogeneic T-cell proliferation, compared to those from saline-treated mice. These results indicate that LC play a crucial role in maintaining cutaneous homeostasis against increasing exposure to external substances resulting from barrier disruption.
Contact allergy to gold and gold therapy in patients with rheumatoid arthritis.
Authors: Möller H , Svensson A , Björkner B , Bruze M , Lindroth Y , Manthorpe R , Theander J.
Published: June 2023

Patients with rheumatoid arthritis were investigated for contact allergy to gold in connection with treatment with gold preparations. There were 57 patients with rheumatoid arthritis previously treated with gold, with or without cutaneous side-effects, as well as 20 patients intended for such treatment
Circulating sICAM-1 during UV therapy of psoriasis.
Authors: Petersen AA , Bech-Thomsen N , Mainolfi EA , Wulf HC , Vejlsgaard GL.
Published: June 2023

No Abstract available
"Clown nose" as a first manifestation of lung carcinoma.
Authors: De Simoni I , Iacovelli P , Lunghi F , Peris K , Chimenti S.
Published: June 2023

No Abstract available
Ketoconazole as a therapeutic modality in subcorneal pustular dermatosis.
Authors: Verma KK , Pasricha JS.
Published: June 2023

No Abstract available
"Twisted and rolled body hairs": an ultrastructural study by means of scanning electron microscopy.
Authors: Barbareschi M , Sibillo E , Greppi F , Bruscagin C , Crosti C.
Published: June 2023

No Abstract available
Flow cytometric DNA content analysis of ultraviolet light-induced squamous cell carcinomas: a comparative study of squamous cell carcinomas of the lip and those arising from other sites of sun-damaged skin.
Authors: Tamura A , Ohnishi K , Ishikawa O , Miyachi Y.
Published: June 2023

The development of squamous cell carcinoma (SCC) of the lip is considered to be mainly related to excessive sun exposure. However, its higher metastatic rate is distinct from that of SCCs arising from other sites of sun-damaged skin. Flow cytometric DNA content analysis, using paraffin-embedded specimens, was performed on 15 SCCs of the lip and 32 SCCs arising from other sites of sun-damaged skin. A significantly lower incidence of DNA-aneuploidy was observed in SCCs of the lip (2/15) than in those of sun-damaged skin (15/32) (p < 0.05). The mean age of patients with SCC of the lip (66.7 +/- 11.6 years
Keratinocytes cultured under hyperthermal conditions secrete factor(s) which can modulate dermal fibroblast proliferation and extracellular matrix production.
Authors: Fujimoto N , Itoh Y , Tajima S , Ishibashi A.
Published: June 2023

We have studied how keratinocytes cultured under hyperthermal conditions modulate skin fibroblast growth potential and their biosynthetic phenotypes in vitro. When keratinocytes were cultured at 30, 34, 37 or 39 degrees C, the conditioned medium of the keratinocytes cultured at 39 degrees C showed a greater inhibitory activity for fibroblast proliferation and greater synthetic activities of collagen and glycosaminoglycans than those incubated at 30, 34, or 37 degrees C. Transforming growth factor (TGF) beta 1 production in skin fibroblasts was also stimulated by the keratinocyte conditioned medium cultured at 39 degrees C. The stimulating activity of collagen and glycosaminoglycan syntheses of keratinocyte conditioned medium may be explained at least partly by enhanced TGF beta 1 production. The results indicate that keratinocytes cultured at a higher temperature (39 degrees C) may secrete factor(s) which modulate both fibroblast growth and matrix synthesis. This may provide evidence that under hyperthermal conditions epidermis can influence the functions of skin fibroblasts.
Evaluation of scratch movements by a new scratch-monitor to analyze nocturnal itching in atopic dermatitis.
Authors: Endo K , Sumitsuji H , Fukuzumi T , Adachi J , Aoki T.
Published: June 2023

Itching is very important in atopic dermatitis, but the details of itching or scratch movements, especially during sleep at night, have not yet been fully comprehended. We designed a new, simple device, the Scratch-Monitor (SM), to evaluate scratch movements at night and assessed the usefulness of this device by a comparison involving 26 patients and 17 healthy controls. The SM, a box weighing only 25 g with a pressure sensor on the bottom, is attached to the back of each hand under a cotton glove and records the number as scratch movements per minute in the case of more than three successive changes of pressure. The SM indicated that patients with atopic dermatitis scratched more frequently and suffered more severe sleep disturbance than healthy controls. Although the SM had several problems related to specificity and sensitivity, we conclude that the SM is a useful tool for evaluating nocturnal itching.
Topical application of a platelet-activating factor (PAF) antagonist in atopic dermatitis.
Authors: Abeck D , Andersson T , Grosshans E , Jablonska S , Kragballe K , Vahlquist A , Schmidt T , Dupuy P , Ring J.
Published: June 2023

Platelet-activating factor (PAF acether) is a lipid mediator with a potent proinflammatory activity. Results derived both from in vitro and in vivo studies suggest a possible role of this substance in the pathophysiology of atopic dermatitis. A double-blind, randomized, multi-center, within-patient study was performed to evaluate the efficacy of a topically applied PAF antagonist (RO-24-0238) in 36 patients with atopic dermatitis. Over a period of 28 days, 0.25 ml of the PAF antagonist and the vehicle (placebo) were applied twice daily on opposite sites of symmetrical lesions (measuring 10 to 20 cm2 each). The overall assessment of the therapeutic efficacy did not demonstrate a superior effect of the PAF antagonist in comparison to placebo, and this was the same with the individual study parameters erythema, scaling, induration and exudation. For reducing pruritus, as assessed by the patient using a visual analogue scale, a statistically significant action was documented during the first 2 weeks of the study (p < 0.04
Evaluation of a self-reported questionnaire on hand dermatosis in secondary school children.
Authors: Yngveson M , Svensson A , Isacsson A.
Published: June 2023

The purpose of this study was to investigate the reliability and validity of a self-reported questionnaire for estimating the prevalence of hand eczema and other hand dermatoses. All pupils in grades 1 and 3 from the secondary schools in Växjö, in southern Sweden, were invited to participate in the study, which consisted of two parts, a questionnaire and a clinical examination. Of those invited, 2572 (98.6%) responded to the questionnaire. Of the respondents, 2535 pupils (98.5%) were clinically examined. The kappa value for the questionnaire findings, compared with the diagnosis from the clinical examination, was 0.79, indicating good agreement. The sensitivity of the questionnaire findings was 73% (95% confidence interval [CI]: 0.6425-0.7975), and the specificity was 99% (95% confidence interval [CI]: 0.9860-0.9940). The self-reported questionnaire was suitable for detecting hand dermatosis in a population of secondary school children and may be used as a cost-effective and reliable method of investigating the prevalence of hand dermatosis in epidemiological studies.
A pleomorphic liposarcoma imitated a subcutaneous cyst.
Authors: Geltinger S , Thewes M , Abeck D , Vocks E , Worret WI , Roder JD , Ring J.
Published: June 2023

No Abstract available
Lithium therapy associated with hidradenitis suppurativa.
Authors: Marinella MA.
Published: June 2023

No Abstract available
Acquired perforating collagenosis in a patient with carcinoma of the prostate.
Authors: Boeck K , Mempel M , Hein R , Ring J.
Published: June 2023

No Abstract available
A case of dermatomyositis triggered by tegafur.
Authors: Akiyama C , Osada A , Sou K , Yasaka N , Ohtake N , Furue M , Tamaki K.
Published: June 2023

No Abstract available
Malignant epithelioid schwannoma with melanocytic differentiation: a rare tumour with an unusual feature.
Authors: Thewes M , Jungfer-Weber B , Wiebecke B , Engst R , Ring J.
Published: June 2023

No Abstract available
Long-term results of patients with onychomycosis treated with itraconazole.
Authors: Heikkilä H , Stubb S.
Published: June 2023

We studied the long-term results of 88 patients treated with itraconazole either with continuous or pulse therapy. No differences were noted in the treatment results between these two groups. Thirty-six weeks after cessation of a 12-week drug therapy total clinical cure was achieved in 35% of these patients with 93% negative culture. At a follow-up at week 104 the total clinical cure was 39%, with negative culture in 57%.
Chemotherapy-induced acral erythema due to Tegafur.
Authors: Bastida J , Díaz-Cascajo C , Borghi S.
Published: June 2023

No Abstract available
Erythema nodosum and acute Q fever: report of a case with granulomatous hepatitis and immunological abnormalities.
Authors: Vázquez-López F , Rippe ML , Soler T , Rodríguez A , Arribas JM , Pérez-Oliva N.
Published: June 2023

No Abstract available
Palmar-plantar erythrodysaesthesia syndrome and other cutaneous side-effects after treatment with Tegafur.
Authors: Rios-Buceta L , Buezo GF , Peñas PF , Dauden E , Fernandez-Herrera J , Garcia-Diez A.
Published: June 2023

No Abstract available
Atypical localization of cutaneous leishmaniasis.
Authors: Aste N , Fumo G , Pau M , Biggio P.
Published: June 2023

No Abstract available
Münchausen's syndrome with congenital generalized epidermolysis bullosa simplex.
Authors: Le Coz CJ , Cribier BJ , Boehm N , Schubert B , Heid E , Grosshans EM.
Published: June 2023

No Abstract available
Three-dimensional demonstration of melanocyte distribution of human hair follicles: special reference to the bulge area.
Authors: Narisawa Y , Kohda H , Tanaka T.
Published: June 2023

Melanocytes of human hair follicles were histochemically and immunohistochemically examined in two and three dimensions. EDTA-treated extracted anagen vellus and intermediate hair follicles showed that monoclonal murine antibody (MoAb) NKI/ beteb-reactive melanocytes were distributed from the infundibulum to the bulb. Melanocytes of the infundibulum and bulb were larger and more strongly stained with MoAb NKI/beteb than those of the middle portion below the sebaceous gland. Latter melanocytes showed less dendricity. Dendritic melanocytes were exclusively observed in the bulb as well as the bulge area of vellus and intermediate hair follicles, where they were variably melanized. In longitudinal and transverse sections of adult human scalp some keratinocytes of the outer root sheath of the bulge area were melanized compared to other parts. This phenomenon was independent of the hair cycle. These findings may be characteristic of bulge melanocytes and/or keratinocytes.
Studenters arbete med respons: förstår de vad jag menar?
Authors: Zetterberg Karin
Published: June 2023

Artikeln redovisar resultatet av en studie som ställer två frågor: I vilken mån förstår och engagerar sig studenter i respons av olika slag? Hur uppfattar de icke-selektiv respons på textens lokala nivå?
Studien baserar sig på strukturerade intervjuer med sex studenter på en delkurs i akademiskt skrivande på en fristående kurs på grundnivån. Intervjuerna transkriberades och analyserades kvalitativt. Studenternas svar kodades med hjälp av verktyget Nvivo och sorterades i kategorierna kognitivt engagemang, emotionellt engagemang och handlingar. Analysen visade att det kognitiva engagemanget främst handlade om bedömning av olika typer av respons. Hjälpsam respons var till exempel sådan som går att agera på direkt och som ges vid rätt tidpunkt. Det emotionella engagemanget tog sig uttryck i en mognadsprocess, där känslor av obehag och besvikelse övergick i glädje/tacksamhet. Det kognitiva och emotionella engagemanget ledde i de flesta fall till att responsen integrerades. Den icke-selektiva responsen fungerade för de flesta studenter, särskilt för dem med svenska som andraspråk, men bör kombineras med bekräftande, positiv respons. Sammanfattningsvis låg studenternas utmaning inte främst i att förstå responsen, utan snarare i att hantera de känslor den väckte. 
ENGLISH ABSTRACT
Students work with response – do they understand what I mean?
The article presents the results from a study posing two questions: To what extent do students understand and engage in response of different kinds? How do they experience non-selective response concerning the local level of texts? The study is based on structured interviews with six students taking a class in first-year academic writing at a Swedish university. The interviews were transcribed an analyzed qualitatively. The answers were coded using Nvivo software and sorted into the categories cognitive engagement, emotional engagement and actions. The analysis showed that the cognitive engagement was focused on evaluation of different kinds of response. Helpful feedback was described as response given at a time when it really mattered to the students, and could be put to use immediately. The emotional engagement was expressed as a process of maturation, where feelings of unease and disappointment were replaced by happiness/gratefulness. In most cases, the cognitive and emotional engagement prompted integration of the response into the text. The non-selective response was helpful to most students, especially for L2-learners. The results indicate however, that such response should be combined with confirming, positive feedback. In conclusion: this study shows that the students understood the meaning of my comments on their texts, but the real challenge for them was coping with the feelings generated by the response.
Bokrecencion: Använd rummet
Authors: Edberg Hélène
Published: June 2023

"Använd rummet är med andra ord en handboksliknande antologi för läsare som inte bara funderar över idéerna bakom ALC (Active Learning Classrooms) utan också över vad som vore möjligt att faktiskt genomföra i den egna undervisningspraktiken. Ett ypperligt tillfälle att skaffa sig så kallad spatial kompetens (s. 29, 363) på ett lättillgängligt sätt!" Läs hela Hélène Edbergs recencion av boken Använd rummet her.
What We See. What We Understand: Visual Images of the Colonial Experience (1920-1922)
Authors: Fruzzetti Lina
Published: June 2023

Through the comparative analysis of the representation of colonial subjects in a Catholic British missionary film and a Catholic Italian missionary film, this study reconstructs the imperial imagination that these two religious associations constructed in the early 1920s. This analysis reveals emblematic traits of the British and the Italian ways to colonialism in which the missionaries had a crucial part. Missionary cinema is here considered as a pivotal primary source to understand colonial rules and located in the larger context of early 1920s ethnographic films portraying indigenous people from the African territories.
The Epistemic and Political (Re) Configuration of the Quilombo Category-Historical and Contemporary Narratives
Authors: Rosalina Silva Andréia
Published: June 2023

The aim of this article, based on a brief historical and theoretical review, is to highlight the different conceptions of the Quilombo category over the years in Brazil. Some legal, social and political advances were achieved due to the struggles of the social and black movements in the country, when the communities were present in the Brazilian government agenda, from the recognition of the definitive ownership of the lands that were occupied by their remnants, guaranteed by the 1988 Constitution - Article 68 of the Transitory Constitutional Provisions Act (ADCT), thus constituting a quilombola social agenda, having its institutionalization through the creation of the Secretariat for Policies for the Promotion of Racial Equality (SEPPIR) and the National Council of Promotion of Racial Equality, both in 2003. We thus present the arguments around memory, uses and meanings of history and legislation on quilombos.
Discourses around Racism in Spain
Authors: García Escribano Juan José
Published: June 2023

This article aims to discover the discourse on racism in Spain among the participants of awareness-raising workshops against racism in the Community of Madrid within the framework of the COCO (Against Everyday Hate) project. For this purpose, a mixed methodology was used, using the focus group technique complemented with the Pettigrew and Mertens test of subtle and manifest prejudice, adapted by Frías-Navarro. The literature review discusses racism as a concept, its origin, and typology and analyzes and discusses results and conclusions.
Emphasizing on the Neglected Parts of Risk Management Process in Occupational Health and Safety Management, Using the European Statistics for Accidents at Work Codification, Communication – Human Information Processing Model and Management Standards
Authors: A Targoutzidis
Published: June 2023

Occupational Health and Safety (OHS) management has been one of the first areas of implementation of Risk Management process. However, due to the extended application of OHS management in all organization and the requirements for compliance with relevant legislation, focus for standardization was set mostly on the technical aspects (risk identification and risk evaluation), whereas other aspects (risk treatment, risk communication, monitoring and reporting) were left to be treated ad hoc, intuitively or following regulated requirements. According to the Risk Management process, as described by the standard ISO 31000:2018, these aspects are equally important for effective management of risks. This paper aims to present the whole Risk Management process for OHS risks, emphasizing on these neglected aspects and presenting documented tools to effectively incorporate them in the structured application of OHS management. The importance of defining the scope, context and criteria of OHS management, as well as the selection of certain risk treatment strategy for each risk is emphasized. Use of ESAW (European Statistics for Accidents at Work) taxonomy for risk identification is proposed, an evaluation scheme for measures is presented, the C-HIP model is proposed to be integrated for communication, recording registry information is discussed and ISO 45001:2018 PDCA structure is proposed for continuous monitoring and review.
The Niosh Method Analysis Model Uses Digital Human Modeling
Authors: IBA Swamardika
Published: June 2023

Niosh method is used to obtain Lifting Index (LI) for single task and Composite Lifting Index (CLI) for multi-task work. Getting the value of the Niosh variable as well as getting the results of the analysis requires people to do the work. In this research, Digital Human Modeling (DHM) Tecnomatix Jack is used as a simulator to get Niosh variables and software development using PHP programming language to get LI or CLI results. The result is that DHM can help get the Niosh variable even though the work station has not been created because it can be done by simulation. Software is tested by black box testing and the results are valid.
Different Types of Stress as Highly Complex Endocrine and Biochemical Phenomena: A Reappraisal
Authors: Goudochnikov Viktor I
Published: June 2023

The review is presented for description of physiologic and cellular stress types, together with stress phenomena, factors, reactions, mediators and outcomes. The high complexity of stress phenomena is outlined, discussing various details of HPA axis beyond its classical general scheme. Some ontogenetic and chronobiologic aspects of stress are presented, and stressful procedures of cell culturing are mentioned. It is proposed that future research efforts should be directed especially to borderline area between physiologic and cellular stress and to the comparisons of their subtypes.
Comparison of Efficacy of COVID-19 Leading Vaccines
Authors: Javed Arbi Malik Arslan
Published: June 2023

The aim concerning the review is to compare the efficacy of different well-known and active vaccines. The top vaccines are Pfizer, Moderna, Astra Zeneca, Sinovac, and CanSino for which we will compare the efficacy of these renowned vaccines around the sphere. So, after reviewing and comparing the efficacy of top vaccines we come to accomplish that the most effective vaccines are Sino vac and Pfizer with the efficacy rate of approximately 95% after 2nd dose vaccination in addition Moderna, Johnson and Johnson comes on 2nd with 94% efficacy after 2nd dose and Zydus Cadila secure 3rd rank with 90% efficacy while the least effective vaccines are CanSino comes on number 4th with efficacy of 86% and Astra Zeneca with 82% Efficacy rate rank in number 5th in leading vaccines.
Neuroendocrine Tumor in the Common Bile Duct, a Case Report
Authors: Abu Jeyyab Mohammad
Published: June 2023

Neuroendocrine tumors (NETs) are a rare entity of cancers occurring mainly in women under 50. They account for only 0.5% of all malignancies. NETs arise from secretory cells of the neuroendocrine system that produce peptides causing characteristic hormonal syndromes. Nevertheless, they often present at an advanced stage due to delayed diagnosis. The diagnosis and treatment depend on tumor type, location, aggressiveness, excess hormone production, and metastasis. Due to their rarity, tumor heterogeneity, nonspecific presentation symptoms, and unique indolent biology, NETs remain a poorly understood disease. In this case report, we are looking into a rare entity of these tumors.
Therapeutic Clinical Implications of Crosstalk amongst Gut Microbiota, Bone Health and Vascular Calcification in Chronic Kidney Disease: A Narrative Review
Authors: K Kaur
Published: June 2023

Earlier we had reviewed the part of epigenetic modifications in Diabetic Kidney Disease (DKD), other etiological factors in Chronic Kidney Disease (CKD) besides role of bilirubin in DKD, role of probiotics and prebiotics in obesity, T2DM, NAFLD. Here our objective was to evaluate the part of gut microbiota (GM), bone health and vascular calcification in CKD in this Narrative Review’. Decontrolling of GM might possess part in vascular along with bone disease in case of CKD randomized trial particular. With the reduction in glomerular filtration rate (GFR), escalated production of urea as well as uric acid ensues along with bacterial proteolytic fermentation changes the gut microbiome balance. Diets possessing lesser quantities of fibers along with utilization of medicines like Vitamin K antagonists as well as phosphate binders, iron delivery, antibiotics further aid in alterations in GM diversity in case of CKD patients. Simultaneously both bone disease along with vascular disease usually accompany CKD. Thus here we concentrate on gut dysbiosis, vascular calcification bone demineralization in addition to their interdependence namely the Gut- vascular -bone-axis in CKD is getting validated with greater proof. The part of diet metabolites of gut microbial origin like p-cresyl sulfate, Indoxyl sulfate, Trimethylamine-N-oxide(TMAO), short chain fatty acids(SCFA) Vitamin K deficiency, inflammatory cytokines expression are detailed. This interdependence might open up innovative avenues regarding treatment as well as avoidance for enhancement of cardiovascular along with bone health. Various studies are trying to find the appropriate utilization of various Probiotics as well as Prebiotics supplementation without escalation of inimical actions.
Dietary Modulation of Chronic Inflammation of Diabetes: A Narrative Review
Authors: Joseph Saju
Published: June 2023

Diabetes is a prevalent disease that affects millions of people around the world with severe and costly complications, such as neuropathy, retinopathy, nephropathy, peripheral vascular disease, ischemic heart disease, and cerebrovascular disease. It has been determined that prolonged state of hyperglycemia causes oxidative and nitrosamine stress and ischemia to the tissues, which leads to inflammation that the immune system cannot resolve. Because of this, diabetic patients live in a state of chronic inflammation. Current treatment of diabetes primarily revolves around glycemic control and lifestyle modifications; and while modern diabetic drugs continue to improve, nutritional aspects usually lag in the overall management of the disease. However, well optimized nutrition can not only minimize the source of inflammation and decrease the existing chronic inflammation, but it can also help the immune system to transition into the resolution and repair state. Such anti-inflammatory diet should abide by the following rules: 1) caloric restriction; 2) consumption of adequate amount of proteins; 3) decreased consumption of saturated fats; 4) increased consumption of unsaturated fats, especially omega-3 fatty acids; 5) increased intake of fermented fiber; 6) increased intake of polyphenols; 7) decreased consumption of both arachidonic acid and linoleic acid. It is important to mention that it might not be easy for the patient to switch their diet to the new one and maintain it over the long period of time. However, if done correctly, it might be a relatively cheap and effective addition to the standard medical treatment of diabetes.
Women’s Health in Rural Tamil Nadu
Authors: kumar A Ranjith
Published: June 2023

Rural women are the most marginalized communities in Indian society. They have been denied from mainstream social and economic development which affects overall economic growth. Many welfare policies are being launched and executed in favor of rural people and women, who have been historically marginalized. They continue to be plagued by various issues such as unemployment, poverty, poor health and so on. Rural women, in particular, have poor health status, despite its links to their productivity and human capital. In this aspect, WHO defines that “better health is central to human happiness and well-being. It also makes an important contribution to economic progress, as the healthy population lives longer, is more productive, and save more”. Rural women have limited access and opportunities to make use of health care policies. Rural women face various kinds of problems such as maternity, mother feeding, reproduction, malnutrition and sanitation which are directly affecting GDP. The major objectives of this study are to identify the awareness of key health issues related to women and children in rural areas and to find out the perception of women about the various government schemes and initiatives for tackling health issues in rural areas.
Postmenopausal Osteoporosis Awareness & Management in Women-An Indian Perspective
Authors: Patil Nupur
Published: June 2023

Postmenopausal osteoporosis affects millions of women each year jeopardising their healthcare and quality of life. Initial treatment is based on many factors including T-score, fracture risk assessment tool score, and risk factors for fractures. The most recent additions to treatment are aimed at those who are considered to be at higher fracture risk. The newest FDA-approved medications, abaloparatide and Romosozumab that work to increase bone formation in 18 and 12 months, respectively. Due to lack of awareness in Indian women and with the increase in life expectancy as proved by recent studies, it’s important to find out new medications and better lifestyle options for better management of Postmenopausal osteoporosis to help avoid fragility fractures and improve the quality of life of the Indian women.
Overview of Gang Rape Registered in High Court Province Five of Nepal: An Analytical Study
Authors: Pradhan Savana
Published: June 2023

Rape, which is a heinous crime criminalized by law in Nepal is increasing and includes cases of gang rape. The Case Law Study was done on the 5 years registered cases of gang rape in High Court, Butwal Bench with official ethical permission. There are 6 district courts under the jurisdiction of High Court with diverse population and geographical distribution. There were 472 cases registered as sexual violence. 141 cases with 149 survivors were awarded with final summary hearing; 12% of these were gang rape cases. There were 18 survivors of gang rape with 52 male perpetrators. More than half the survivors of gang rape were minors and almost 90% of perpetrators were adult men, two third of them known to the survivor. The gang attacked to rape a sole vulnerable survivor range from 2 to 8 perpetrators. There were more than 10% male children accompanying adults in the activity. Most of the noted site of gang rape was fields, followed by the survivor’s home. Two thirds of the cases had medical evidence suggestive of violence. One third of the cases were acquitted due to lack of evidence, and few of the survivors were punished with fines for wrongful accusation in the final verdict. There are several challenges and loopholes in the socio-cultural as well as criminal justice system in Nepal which demands to be scrutinized to justify the maxim, ‘Let hundred guilty be acquitted but one innocent should not be convicted’ in heinous crimes such as gang rape.
Comparison between Outcome of Assisted Reproductive Technique (Art) Cycles with and Without OCP Pretreatment in Infertile Women: A Randomized Clinical Trial
Authors: Lapavandani Rozita Safaei
Published: June 2023

The objective of this randomized clinical trial was to assess the effect of pretreatment with oral contraceptive pill (OCP) on assisted reproductive technique outcomes in patient’s candidate for assisted reproductive technique (ART). In a randomized clinical trial University-based infertility center, Tehran, Iran. 160 infertile patient who are candidate for IVF, randomly divided into two groups: 80 patients in OCP pretreatment group and 80 patients in non-OCP pretreatment group. The IVF protocol in all patients was standard long GnRH agonist (long protocol). The oocyte number, embryo formation, fertility rate, gonadotropin dose, ovarian cyst formation and cancelled cycles were evaluated. Oocytes number per patient in OCP group was 13.87 and in non-OCP group was 15.22, pregnancy rate in OCP group was 44.7% and in non-OCP was 31.2%, the abortion rate in OCP group was 10.5% and in non-OCP was 3.1%, that there was no significant difference between two groups, embryo formation in two groups was similar. ovarian cyst in OCP group was 2.6% and in non-OCP was 12.5% (P< 0.05) so the cancelled cycles due to ovarian cyst in OCP group was less than non-OCP group. Based on our data, OCP pretreatment have no effect on oocyte number, embryo formation, pregnancy rate and abortion, but this pretreatment can decrease the cyst formation so decrease the cancelled cycles in OCP pretreatment.
The National HIV Curriculum: Howard University’s Innovative Approach to Strengthening the Nation’s HIV Clinical Workforce
Authors: Downer Goulda A
Published: June 2023

HIV has remained a stubborn burden in the African American community. HIV-experienced clinicians are critical for positive outcomes that align with the HIV care continuum. Howard University (HU) used the National HIV Curriculum (NHC,2015) via distance base technology to fill the void and strengthen HIV care, particularly among students and faculty at our Historically Black Colleges and Universities (HBCUs). One major program success was HUs ongoing ability to access a dedicated core of health sciences faculty to champion the NHC. This approach ensured the successful integration of the NHC into the course offerings at the various HBCUs. The effective integration was accomplished despite the unequal challenge that the COVID-19 pandemic unleashed on the vulnerable communities served by our HBCUs. The project success was achieved through the development and strengthening of ongoing partnerships with our cohort of HBCUs, conducting ongoing needs assessments and responding promptly to the findings, emphasizing training opportunities in addition to the NHC, and providing on-demand technical assistance and resources to our partners. Howard University surpassed by 459% its original goal of engaging 1964 students to take the NHC. At the conclusion of the four-year project performance period 10,983 students completed all or part of the NHC.
A graph based deep learning technology application in degenerative polyarthritis associated genes prediction
Authors: Qu Z. , Niu D.
Published: June 2023

Abstract: Degenerative polyarthritis is the most common joint disease and affects millions of people worldwide. However, there is currently no cure for degenerative polyarthritis and no effective methods to prevent or slow down its progression. Gene regulatory relationships are vital for understanding disease mechanisms and developing treatment and novel drugs. Gene regulatory networks can be obtained from the RNA sequencing. Although various single-cell and bulk RNA sequencing data are available, an effective method to integrate the data for molecular diagnosis and treatment of degenerative polyarthritis has not yet been carried out. Here, we propose a novel deep learning-based method to efficiently capture the gene regulatory features of degenerative polyarthritis. First, we integrate single-cell RNA sequencing data-based gene regulatory network to model the gene regulatory relationships between genes and transcription factors as node feature aggregation. Second, we propose a graph convolutional model named dpTF-GCN on gene regulatory graph to transmit and update the node feature for potential associated genes predicting. According to the results, dpTF-GCN achieved the best performance among represented network-based methods. Furthermore, case studies suggest that dpTF-GCN can identify potential associated genes accurately. Our research not only provides theoretical and methodological support for the study of degenerative polyarthritis, but also provides a research case for the application of graph neural network-based identification of associated genes in other diseases.
WORDWALL SEBAGAI MEDIA EVALUASI ASESMEN TODAY UNTUK MENINGKATKAN KEAKTIFAN SISWA PEMBELAJARAN IPAS KELAS 4 SD
Authors: Furliana Devi , Restian Arina , Supradana Arif
Published: June 2023

The results of observations and observations at SDN Tanjungsari 2 Blitar City, found that low student activeness in IPAS lessons on Indonesian cultural diversity can affect student learning outcomes. In addition, there is no IPAS learning media that suits the needs of students. The purpose of this observation is to increase activeness by using wordwall games as an evaluation media for today's assessment in class 4 SD on the material of Indonesian cultural diversity. This observation uses classroom action research carried out in two cycles consisting of two meetings guided by the Kurt Lewin model. The subjects of this study were 4th grade students totaling 28 people consisting of 14 girls and 14 boys. The research object is the activeness and daily learning outcomes of IPAS. Classroom action research is carried out up to four stages, namely planning, implementation, observation, and reflection. The instruments used were evaluation questions to steam the evaluation results and student response sheets to measure student activeness. The type of data taken from the evaluation results and student activeness.  The results of observations of wordwall learning which is one of the interactive containers that is simple and easy to use, and can increase student activeness in learning IPAS grade 4 SD. Based on the evaluation results and student response sheets, it is concluded that wordwall as an assessment evaluation media today to increase student activeness in learning IPAS grade 4 elementary school.
The Effectiveness of Memrise Application toward Students' Adjective Mastery
Authors: Pradana Satria Adi , Marselina Silvia Dwi , Yudha Galang Tirta
Published: June 2023

This research was conducted because it was discovered that students had difficulty learning vocabulary, especially adjectives, and it was set against the background of several student problems. For instance, utilizing continuous paper-based learning to teach vocabulary resulted in boredom and could demotivate students. Dealing with that, one alternative solution was provided to the problem by implementing the memrise media to be tested in the learning process toteach adjectives. The research objective was to know the effectiveness of using memrise towards students' adjective mastery. Thus, this research used a quasi-experimental design and chose two classes by using cluster random sampling as the sample. The research instrument was tests, the results of which were analyzed using an independent sample t-test. The hypothesis testing results revealed that a significant value of 0.025 was obtained with a significance of α = 0.05. Thus, there was effectiveness in using memrise application toward students' adjective mastery. Furthermore, the N-Gain score for the control class was 0.46, while for the experimental class was 0.58. Therefore, it could be stated that the memrise can be used and is effective as learning mediafor adjectives mastery for seventh grade students of SMP N 3 Pringsewu
Impact of Uncertainty Quantification on Small Signal Stability of Power System
Authors: Suravi Thakur  , Nilanjan Senroy
Published: June 2023

The statistical uncertainty quantification of the injected uncertainties into a power system has been done to study the response of the power system to such injected randomness. The dominant electromechanical modes have been analysed and the frequency spectrum of the trajectories obtained for various state variables has been used to measure the impact of injected randomness on the system. The idea of Statistical Distance between the point of input perturbations and output measurement data has been explored.The simulation results indicate that there is a direct relationship between the input uncertainty and output measurement variable and is greatly affected by the magnitude and location of random injection. The above framework has been validated using Kundur'stwo area system and IEEE 14 Bus system.
Integrated historical and religious tourism model of Syech Quro's tomb complex in Karawang Regency, West Java Province, Indonesia
Authors: Mariati Sri , Rahmanita Myrza , Ingkadijaya Rahmat , Habibie Fachrul Husain
Published: June 2023

The background of this research is Karawang Regency has various tourism potentials, one of which is historical and religious tourism of Syech Quro's Tomb. One of the important phenomena of the existence of Sheikh Quro's Tomb is the relatively high number of visits, even during the pandemic there were still many tourists visiting and it has increased again after the pandemic. The purpose of the research is to build an integrated historical and religious tourism model at the Syech Quro Tomb Complex in Karawang Regency, West Java Province. The research method used to build the model uses a Participatory prospective analysis which begins by selecting and taking the driving factors and determinants with judgment from experts. The results of this study place agro-tourism development factors as determining factors or driving the success of the integrated and reorganized religious tourism model, institutional strengthening programs, inter-agency relations, local community involvement, incentive funding, and culinary tourism as driving factors for the success of this model. This model is a powerful intervention on ongoing factors. This intervention was carried out in an integrated manner based on the consideration of the need to make integrated tourism at the Syech Quro Tomb Complex a model that must consider economic, social, and ecological sustainability and all village communities support this integrated tour because the benefits can be felt by all surrounding village communities.
PENGARUH STRATEGI PEMBELAJARAN STUDENT ACTIVE LEARNING BERBASIS PROBLEM SOLVING TERHADAP HASIL BELAJAR EKONOMI
Authors: Anggreani Via , Dewi Tiara Anggia , Ningrum Ningrum
Published: June 2023

Pelaksanaan pembelajaran menggunakan strategi pembelajaran aktif (active learning) berbasis problem solving dalam penelitian ini adalah pertama kegiatan pembelajaran pendahuluan, dimana guru menyiapkan bahan ajar yang menarik. Tujuan Penelitian ini adalah untuk mengetahui adanya pengaruh penggunaan strategi pembelajaran student active learning berbasis problem solving terhadap hasil belajar ekonomi Kelas X IPS 2 SMA Negeri 2 Sekampung. Penelitian ini menggunakan desain eksperimen jenis quasi eksperimen. Rancangan pada penelitian ini adalah nonequivalent control group design. Desain ini hampir sama dengan pretest-posttest control group design. Sampel pada penelitian ini sebanyak 65 siswa yang terbagi ke dalam dua kelas yaitu kelas X IPS 2 sebanyak 32 siswa sebagai kelompok eksperimen dan kelas X IPS 3 sebanyak 33 siswa sebagai kelompok kontrol. Sampel adalah bagian dari populasi.

Berdasarkan analisis data dan hasil pengujian hipotesis dalam penelitian ini, dapat disimpulkan bahwa hasil pengumpulan data dalam penelitian ini sebanyak 32 siswa yang diberikan perlakuan (treatment) menggunakan strategi pembelajaran student active learning berbasis problem solving terhadap hasil belajar ekonomi siswa kelas X IPS SMA Negeri 2 Sekampung, siswa yang tuntas sebesar 56,25% atau 18 siswa, sedangkan peserta didik yang belum mencapai ketuntasan adalah 43,75% atau 14 siswa. Hasil pengujian menggunakan uji thitung berdasarkan analisis yang telah dilakukan terbukti bahwa ada pengaruh penggunaan strategi pembelajaran student active learning berbasis problem solving terhadap hasil belajar ekonomi Kelas X IPS 2 SMA Negeri 2 Sekampung, dimana nilai thitung lebih besar daripada nilai ttabel yaitu sebesar 2,87 > 1,69. Dengan demikian hasil belajar ekonomi siswa dari uji pre test dan post test setelah diberikan perlakuan (treatment) menggunakan strategi pembelajaran student active learning berbasis problem solving terhadap hasil belajar ekonomi siswa kelas X IPS SMA Negeri 2 Sekampung dapat disimpulkan hipotesis diterima.
Musical Thinking and Its Educational Implications
Authors: Strenáčiková Mária
Published: June 2023

Many papers, articles, and even books are devoted to musical thinking, approaching it from different perspectives. After a long development of the concept, it appears to be most elab- orated in the field of music psychology. However, it also has its representation in aesthetics, ethnomusicology, computer science, and, marginally, in education. Although it receives less attention today than in the past, it still has its own meaning, and its development is also occurring in music education. Musical thinking is being developed in all music education activities, perceptual, vocal, instrumental, musical-motor, and music-dramatic. Although the musical mindsets of performers, percipients, and composers differ, it is possible to contribute to their development in music education lessons by introducing new, optional subjects and adjusting the teaching methods and the classroom climate. The quality of musical thinking influences the quality of musical activities, so it needs purposeful attention.
Reflections on being an academic with ADHD
Authors: Rangiwai Byron
Published: June 2023

My reflections on being an adult with ADHD and an academic contribute insights into living with, and managing the everyday reality of, this neurodevelopmental disorder. Narrating my personal story from struggles to successes within the education system and on to academia, I believe there is a gap in the literature with regard to Māori perspectives on attention deficit hyperactivity disorder.
Modeling Urban Spaces with Cubes: Building analogue serious games for collaborative planning
Authors:   CITTA, Department of Civil Engineering, University of Coimbra, da Silva Sousa Micael
Published: June 2023

Games are popular as ever. Professionals from every field are trying to build their serious games, combining engaging playability with simulation and learning outcomes. Urban planning is no exception. However, materializing these games is no easy task. We propose a serious game development process to combine modern board game mechanisms with realistic urban maps, profiting from the simplicity, flexibility, and collaboration dynamics analogue games provide. For this, we tested two collaborative games with architecture students. Although different, the games have similar core mechanical and economic systems, modelling urban zones with hexagons and squares. The experience revealed some pitfalls to avoid in game-based planning practice and helped to define a development process for serious games for urban planning.