bluuebunny/crossref_metadata_2025 huggingface dataset:
Translation and Cross-Cultural Adaptation of SATIS-Stroke for Use in Brazil: A Satisfaction Measure of Activities and Participation in Stroke Survivors
Authors: Pereira Gabriela Santos , Silva Soraia Micaela , Júlio Cíntia Elord , Thonnard Jean-Louis , Bouffioulx Edouard , Corrêa João Carlos Ferrari , Corrêa Fernanda Ishida
Published: February 2019

Introduction. SATIS-Stroke was developed to measure satisfaction regarding activities and participation among stroke survivors based on the concepts contained in the International Classification of Functioning, Disability, and Health. However, this measure is only available in English and French. Objective. Perform the translation and cross-cultural adaptation of SATIS-Stroke to Brazilian Portuguese and test the preliminary reliability of this measure. Methods. The translation process followed standardized guidelines and consisted of six phases: initial translation, back-translation, analysis of expert committee, test of final version, submission, and assessment of all written reports. To test the preliminary test-retest reliability, the measure was administered by a single observer on two occasions with an interval of 7 to 14 days for the determination of intraobserver agreement and administered again by a second observer for the determination of interobserver agreement. Reliability was analyzed using the intraclass correlation coefficient (ICC2,1) and respective 95% confidence intervals (CI). Results. All stages of the cross-cultural adaptation process were respected and the final translated version of SATIS-Stroke exhibited semantic, idiomatic, cultural, and conceptual equivalence to the original version. The preliminary analysis revealed excellent intraobserver and interobserver reliability (ICC = 0.93; 95% CI: 0.83-0.97, p = 0.001 and ICC = 0.90; 95% CI: 0.74-0.96; p = 0.001, respectively). The items demonstrated adequate internal consistency, although ceiling and floor effects were considered beyond acceptable standards for some items. In the exploratory factor analysis, three factors were extracted that aggregated more than one construct to each component, but all were related to the “Activities and Participation” component of the International Classification of Functioning, Disability, and Health. Conclusion. The final version of the SATIS-Stroke scale in Brazilian Portuguese proved to be adequate and reliable for use on the Brazilian population. Further studies are underway to give continuity to the validation process and analyze the others measurement properties of the scale in the Brazilian population.
Blockage of TGF-α Induced by Spherical Silica Nanoparticles Inhibits Epithelial-Mesenchymal Transition and Proliferation of Human Lung Epithelial Cells
Authors: Li YiXun , Li Huan , Duan Yong , Cai XueMei , You DingYun , Zhou Feng , Yang ChuanQi , Tuo XiaoYu , Liu ZiJie
Published: February 2019

Background. Xuanwei City in Yunnan province has been one of the towns with highest lung cancer mortality in China. The high content of amorphous silica in the bituminous coal from Xuanwei of Yunnan is mainly present as irregular and spherical silica nanoparticles (SiNPs). It has been reported that silica nanoparticles in bituminous coal correlated with the high incidence of lung cancer in Xuanwei. To explore the role and mechanism of SiNPs in the tumorigenesis of lung cancer in Xuanwei, human mononuclear cells (THP-1) and human bronchial epithelial cells (BEAS-2B) were cocultured in a transwell chamber. Combined with Benzo[a]pyrene-7, 8-dihydrodiol-9, and 10-epoxide (BPDE), SiNPs could significantly promote the proliferation and Epithelial-Mesenchymal Transition (EMT) and inhibit apoptosis of BEAS-2B cells and induce the release of TGF-α from THP-1 cells. After neutralizing TGF-α with antibody, the proliferation and EMT were decreased and enhanced apoptosis of BEAS-2B cells. Furthermore, the results showed that TGF-α in the sera of patients with lung adenocarcinoma in Xuanwei were significantly higher than in patients with benign pulmonary lesions in Xuanwei and those with lung adenocarcinoma in outside of Xuanwei of Yunnan. Taken together, our study found that SiNPs promoted the proliferation and EMT of BEAS-2B cells by inducing the release of TGF-α from THP-1 cells.
An Adaptive Boosting Algorithm for Image Denoising
Authors: Fang Zhuang , Yi Xuming , Tang Liming
Published: February 2019

Image denoising is an important problem in many fields of image processing. Boosting algorithm attracts extensive attention in recent years, which provides a general framework by strengthening the original noisy image. In such framework, many classical existing denoising algorithms can improve the denoising performance. However, the boosting step is fixed or nonadaptive; i.e., the noise level in iteration steps is set to be a constant. In this work, we propose a noise level estimation algorithm by combining the overestimation and underestimation results. Based on this, we further propose an adaptive boosting algorithm that excludes intricate parameter configuration. Moreover, we prove the convergence of the proposed algorithm. Experimental results that are obtained in this paper demonstrate the effectiveness of the proposed adaptive boosting algorithm. In addition, compared with the classical boosting algorithm, the proposed algorithm can get better performance in terms of visual quality and peak signal‐to‐noise ratio (PSNR).
Rician Noise Removal via a Learned Dictionary
Authors: Lu Jian , Tian Jiapeng , Shen Lixin , Jiang Qingtang , Zeng Xueying , Zou Yuru
Published: February 2019

This paper proposes a new effective model for denoising images with Rician noise. The sparse representations of images have been shown to be efficient approaches for image processing. Inspired by this, we learn a dictionary from the noisy image and then combine the MAP model with it for Rician noise removal. For solving the proposed model, the primal‐dual algorithm is applied and its convergence is studied. The computational results show that the proposed method is promising in restoring images with Rician noise.
A Novel Incipient Evaluation Method for Postconstruction Settlement by Using a Statistic Approach with Time‐Extended Loading Test
Authors: Hong Baoning , Shan Hao , Liu Xin , Xu Fenqiang , Sheng Ke
Published: February 2019

This paper proposes an incipient assessment method for postconstruction settlement of highway subgrade by using statistical analysis approach with an improved static loading test method, time‐extended loading test. The time‐extended loading residual settlement Sr(t) and settlement rate Vs(t) are calculated from the field test data. The test procedure and the corresponding experimental validations are presented. Based on the field test data, a probabilistic model is built to bridge the final residual settlement and the actual postconstruction settlements. The proposed time‐extended loading test based assessment system has been validated through three operating and well‐documented road sections. According to the validation results, the construction quality can be accurately evaluated at an early stage and the corresponding remedial measures can be applied timely.
Phytochemical Study of Aqueous Extract of Ochna schweinfurthiana F. Hoffm Powder Bark and Evaluation of Their Anti-Inflammatory, Cytotoxic, and Genotoxic Properties
Authors: Djova Steve V. , Nyegue Maximilienne A. , Messi Angelique N. , Afagnigni Alian D. , Etoa François-X.
Published: February 2019

Ochna schweinfurthiana has been used in traditional medicine to treat pain, inflammation, and arthritis. It is a rich source of complex dimers of flavonoids with potential use as templates for the development of therapeutic drugs. Hence, the aim of this study was to study the phytochemical content and evaluate the in vitro cytotoxic, genotoxic, and anti-inflammatory activities of the aqueous extract of Ochna schweinfurthiana bark (OSE). Phytochemical study was carried out according to LC-MS procedures, while isolation was carried out using thin layer and column chromatographies. Cytotoxicity was investigated by the mitochondrial viability [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] (MTT) method while genotoxicity potential of the extract was ascertained using the Salmonella typhimurium test strains TA98 and TA100. The anti-inflammatory effect of OSE was evaluated by the in vitro inhibition of 15-lipooxygenase enzyme and bovine serum albumin denaturation (BSA) assays. The investigation of compounds extracted from OSE led to the identification and isolation of six known compounds, namely, hemerocallone (9), 6,7-dimethoxy-3’-4’-dimethoxyisoflavone (10), lithospermoside (13), amentoflavone (14), agathisflavone (15), and β-D-fructofuranosyl-α-D-glucopyranoside (17). In the anti-inflammatory assay, aqueous extracts of the bark showed selective inhibition of 15-lipooxygenase with IC50 value of 32.2±0.36  μg/mL and the result of the bovine serum albumin denaturation assay with IC50 value of 130± 5.78 μg/mL showed moderate activity. The toxicity assay indicated that OSE are noncytotoxic on Vero cell line with LC50 value of 50 mg/mL and nongenotoxic toward Salmonella typhimurium tester strain TA98 and TA100. Result from this study supports the traditional use of the selected medicinal plants in Cameroon for the treatment of inflammatory conditions. Noncytotoxicity and nongenotoxicity of OSE suggest that this plant is safe for use.
Therapeutic Effect of Traditional Chinese Medicine on a Rat Model of Branch Retinal Vein Occlusion
Authors: Long Pan , Yan Weiming , Liu Jianwen , Li Manhong , Chen Tao , Zhang Zuoming , An Jing
Published: February 2019

Branch retinal vein occlusion (BRVO) is a common retinal vascular disorder leading to visual impairment. Currently, the general strategies for BRVO are symptomatic therapies. Cardiovascular aspects are essential risk factors for BRVO. The traditional Chinese medicine hexuemingmu (HXMM), consisting of tanshinol and baicalin, dilates the vasculature and accelerates microcirculation. Therefore, the aim of this study was to determine the efficacy and possible mechanism of HXMM in a BRVO rat model established by laser photocoagulation. Successful BRVO rat models were treated with different doses of HXMM. Fundus photography and fluorescein fundus angiography (FFA) of the animals were applied. The retinal layers were measured by optical coherence tomography (OCT). Full-field electroretinography (ffERG) was applied to evaluate the retinal function. The ear vein flow velocity was measured via a microcirculation detector. The expression of the vascular endothelial growth factor (VEGF-α) was measured via western blotting and immunofluorescent staining. Our study found that retinal edema predominantly occurred in the inner nuclear layer (INL) and outer nuclear layer (ONL). The retinal edema of the treated groups was significantly relieved in the early stage of BRVO as visualized via OCT detection and HE staining. The amplitudes of the b wave and oscillatory potentials (OPs) waves of ffERG in the treated groups were increased compared with those of the control group at several detection points (3, 5, 7, 10, 14, and 21 d postocclusion). The expression of VEGF-α was reduced in the treated groups at an early stage of BRVO. Furthermore, the ear vein flow velocity of the HXMM treatment groups was faster than that of the control group. Thus, our study indicates that the traditional Chinese medicine HXMM could ameliorate retinal edema and rescue the retinal structure and function in BRVO models through promoting occluded vein recanalization, improving microcirculation, and regulating the expression of VEGF-α.
Gene-Level Regulation of Acupuncture Therapy in Spontaneously Hypertensive Rats: A Whole Transcriptome Analysis
Authors: Ma Si-Ming , Yang Jing-Wen , Tu Jian-Feng , Yang Na-Na , Du Yu-Zheng , Wang Xue-Rui , Wang Lu , Huang Jin , Liu Cun-Zhi
Published: February 2019

Hypertension is a global health problem. It has been reported that acupuncture at Taichong acupoints (LR3) decreases high blood pressure in spontaneously hypertensive rats. A transcriptome analysis can profile gene expression and its relationship with acupuncture. In this study, rats were treated with 2 weeks of acupuncture followed by regular recording of blood pressure (BP). The mRNA changes in the rostral ventrolateral medulla (RVLM) were evaluated to uncover the genetic mechanisms of acupuncture by using a whole transcript array (Affymetrix Rat Gene 1.0 ST array). BP measurements showed that acupuncture significantly decreased systolic blood pressure (SBP), mean arterial pressure (MAP), and heart rate (HR). In the bioinformatics results, 2371 differentially expressed genes (DEGs) were identified, where 83 DEGs were overlapped among Wistar-Kyoto rats (WKYs), spontaneously hypertensive rats (SHRs), and SHRs + acupuncture rats (SHRs+Acu). Gene ontology (GO) and pathway analysis revealed that 279 GO terms and 20 pathways with significant differences were related to oxidative stress, inflammation, and vascular endothelial function. In addition, coexpressed DEGs networks indicated that Cd4 and Il-33 might mediate the cascade of inflammation and oxidative stress responses, which could serve as a potential target of acupuncture treatment. In conclusion, our study demonstrated that acupuncture is a promising therapy for treating hypertension and could regulate multiple biological processes mainly involving oxidative stress, inflammation, and vascular endothelial function.
The Specific Inhibition of SOD1 Selectively Promotes Apoptosis of Cancer Cells via Regulation of the ROS Signaling Network
Authors: Li Xiang , Chen Yuanyuan , Zhao Jidong , Shi Jiayuan , Wang Mingfang , Qiu Shuang , Hu Yinghui , Xu Yulin , Cui Yanfang , Liu Chunrong , Liu Changlin
Published: February 2019

Multiple signaling pathways including ERK, PI3K-Akt, and NF-κB, which are essential for onset and development of cancer, can be activated by intracellularly sustained high levels of H2O2provided by elevated activity and expression of copper/zinc superoxide dismutase (SOD1) that catalyzes the dismutation of O2•−into H2O2. Here, tests performed by the utilization of our designed specific SOD1 inhibitor LD100 on cancer and normal cells reveal that the signaling pathways and their crosstalk to support cancer cell growth are repressed, but the signaling pathways to promote cancer cell cycle arrest and apoptosis are stimulated by specific SOD1 inhibition-mediated ROS changes. These regulated pathways constitute an ROS signaling network that determines the fate of cancer cells. This ROS signaling network is also regulated in SOD1 knockdown cells. These findings might facilitate disclosure of action mechanisms by copper-chelating anticancer agents and design of SOD1-targeting and ROS signaling pathway-interfering anticancer small molecules.
A Feedback Loop between Hypoxia and Matrix Stress Relaxation Increases Oxygen-Axis Migration and Metastasis in Sarcoma
Authors: Lewis Daniel M. , Pruitt Hawley , Jain Nupur , Ciccaglione Mark , McCaffery J. Michael , Xia Zhiyong , Weber Kristy , Eisinger-Mathason T.S. Karin , Gerecht Sharon
Published: February 2019

Upregulation of collagen matrix crosslinking directly increases its ability to relieve stress under the constant strain imposed by solid tumor, a matrix property termed stress relaxation. However, it is unknown how rapid stress relaxation in response to increased strain impacts disease progression in a hypoxic environment. Previously, it has been demonstrated that hypoxia-induced expression of the crosslinker procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 (PLOD2), in sarcomas has resulted in increased lung metastasis. Here, we show that short stress relaxation times led to increased cell migration along a hypoxic gradient in 3D collagen matrices, and rapid stress relaxation upregulated PLOD2 expression via TGFβ-SMAD2 signaling, forming a feedback loop between hypoxia and the matrix. Inhibition of this pathway led to a decrease in migration along the hypoxic gradients. In vivo, sarcoma primed in a hypoxic matrix with short stress relaxation time enhanced collagen fiber size and tumor density and increased lung metastasis. High expression of PLOD2 correlated with decreased overall survival in patients with sarcoma. Using a patient-derived sarcoma cell line, we developed a predictive platform for future personalized studies and therapeutics. Overall, these data show that the interplay between hypoxia and matrix stress relaxation amplifies PLOD2, which in turn accelerates sarcoma cell motility and metastasis.

Significance:

These findings demonstrate that mechanical (stress relaxation) and chemical (hypoxia) properties of the tumor microenvironment jointly accelerate sarcoma motility and metastasis via increased expression of collagen matrix crosslinker PLOD2.
BCL6 Evolved to Enable Stress Tolerance in Vertebrates and Is Broadly Required by Cancer Cells to Adapt to Stress
Authors: Fernando Tharu M. , Marullo Rossella , Pera Gresely Benet , Phillip Jude M. , Yang Shao Ning , Lundell-Smith Geoffrey , Torregroza Ingrid , Ahn Haelee , Evans Todd , Győrffy Balázs , Privé Gilbert G. , Hirano Masayuki , Melnick Ari M. , Cerchietti Leandro
Published: February 2019

Several lines of evidence link the canonical oncogene BCL6 to stress response. Here we demonstrate that BCL6 evolved in vertebrates as a component of the HSF1-driven stress response, which has been co-opted by the immune system to support germinal center formation and may have been decisive in the convergent evolution of humoral immunity in jawless and jawed vertebrates. We find that the highly conserved BTB corepressor binding site of BCL6 mediates stress adaptation across vertebrates. We demonstrate that pan-cancer cells hijack this stress tolerance mechanism to aberrantly express BCL6. Targeting the BCL6 BTB domain in cancer cells induces apoptosis and increases susceptibility to repeated doses of cytotoxic therapy. The chemosensitization effect upon BCL6 BTB inhibition is dependent on the derepression of TOX, implicating modulation of DNA repair as a downstream mechanism. Collectively, these data suggest a form of adaptive nononcogene addiction rooted in the natural selection of BCL6 during vertebrate evolution.

Significance:

We demonstrate that HSF1 drives BCL6 expression to enable stress tolerance in vertebrates. We identify an HSF1–BCL6–TOX stress axis that is required by cancer cells to tolerate exposure to cytotoxic agents and points toward BCL6-targeted therapy as a way to more effectively kill a wide variety of solid tumors.

This article is highlighted in the In This Issue feature, p. 565
ВПЛИВ СТЕНОЗУ АОРТОКЛУБОВОГО СЕГМЕНТА НА УЛЬТРАСТРУКТУРНУ ОРГАНІЗАЦІЮ ГЕМОКАПІЛЯРІВ ГОЛОВНОГО МОЗКУ В ЩУРІВ
Authors: Havryshchuk Yu. M. , Herasymiuk I. Ye. , Genyk T. R.
Published: February 2019

Зміна характеру центральної гемодинаміки може як передувати, так і ускладнювати перебіг гострого ішемічного ураження головного мозку. Причому серцево-судинні порушення, що призводять до розвитку гострого ішемічного ураження головного мозку, складають близько 30–40 % у структурі усіх патогенетичних варіантів.

Мета дослідження – встановити особливості ультраструктурних змін у стінках гемокапілярів головного мозку щурів після стенозу аортоклубового сегмента.

Матеріали і методи. Експерименти проведено на 18 статевозрілих білих лабораторних щурах-самцях масою тіла 160–180 г. З них 3 тварини склали контрольну групу. Іншим 15 щурам під кетаміновим знеболюванням звужували черевний відділ аорти безпосередньо над її біфуркацією на 2/3 діаметра. Матеріал для електронно-мікроскопічних досліджень забирали через 1; 3; 7; 14 і 28 діб після операції згідно із загальноприйнятою методикою.

Результати досліджень та їх обговорення. Проведене електронно-мікроскопічне дослідження структурних компонентів кори півкуль головного мозку щурів після експериментального стенозу каудального відділу черевної аорти свідчить про етапність морфофункціональної перебудови та ремоделювання гемомікроциркуляторної ланки, у динаміці яких можна виділити наступні періоди:

– альтерації (набряк цитоплазми ендотеліоцитів з одночасними деструктивними змінами органел, нерівномірним потовщенням базальної мембрани та розширенням периваскулярних просторів) – безпосередньо після стенозування і до 3-ї доби спостереження;

– адаптаційно-компенсаторних змін – з 3-ї до 7-ї доби експерименту зі стабілізацією морфофункціонального стану гемомікроциркуляторного русла (зменшення набряку цитоплазми ендотеліоцитів, більш збережений стан органел, чіткі контури базальної мембрани);

– відновні – з 14-ї до 28-ї доби спостереження із зворотним розвитком альтераційних змін і суттєвим, однак не повним, відновленням початкового стану структурних компонентів стінок гемокапілярів головного мозку.

Висновки. Морфофункціональна перебудова та ремоделювання структурних компонентів гемокапілярів кори півкуль головного мозку щурів після експериментального стенозу каудального відділу черевної аорти відбуваються поступово за наступними періодами: альтерації – безпосередньо після стенозування і до 3-ї доби спостереження; компенсації – з 3-ї до 7-ї доби експерименту і часткового відновлення у більш віддалені терміни.
ALGORITHM FOR SPEECH DISORDERS CORRECTION USING PROPRIETARY CONSTRUCTION DEVICE
Authors: Flis P. P. , Filonenko V. V. , Melnyk A. O. , Nemyrovych Y. P. , Lopoha A. P.
Published: February 2019

Currently, there is a tendency in Ukraine to increase the number of children with speech disorders. One of the most common disorders of speech function is dyslalia. Speech therapists are the main form of correctional training, children are assigned certain and consistent stages of speech therapy. Along with that, various individual and standard devices are used.

The aim of the study – to conduct logopedic correction of speech disorders in patients with physiologic occlusion using the in-house designed device according to the proposed algorithm.

Materials and Methods. A survey was conducted on 73 children (24 – aged 3 to 6 years, 49 – from 6 to 12 years old) without significant orthodontic pathology in the presence of speech impairment with normal hearing and intelligence and speech correction. In addition to logopedic exercises, it was recommended to use vestibular plates Dr. Hinz - MUPPY-P with beads, removable orthodontic devices with beads, Bluegrass appliances, devices for elimination and prevention of unhealthy tongue habits. In order to identify early risk factors for major dental diseases, the hygienic state of the cavity of the mouth, the intensity of caries, the presence or absence of inflammatory processes in the tissues of periodontal disease were determined.

Results and Discussion. The first step in the algorithm for successful correction of speech disorders were to explain its necessity. The second stage involved the phonetic diagnosis of all aspects of speech, logic, intelligence, memory and thinking. Polymorphic dyslalia was diagnosed in all subjects of reporting panel. The third stage of the algorithm is to carry out work to overcome the abnormalities of the phonetic side of speech was a direct speech correction. The proposed device for elimination and prevention of unhealthy tongue habits was used in 6 cases.

Conclusions. After the speech therapy correction correct articulation and sound were formed. The proposed device for the elimination and prevention unhealthy tongue habits should be used in conjunction with speech therapy, in particular, dyslalia. In addition to the positive logopedic effect of the proposed therapeutic and prophylactic measures, we have also received improvement of the hygienic state of the oral cavity, the absence of an increase in the intensity of the caries of permanent teeth and increased motivation in patients.
АНТИТІЛА ДО РЕЦЕПТОРІВ ТИРЕОТРОПНОГО ГОРМОНУ, ТИРЕОПЕРОКСИДАЗИ ТА ГОРМОНАЛЬНА ФУНКЦІЯ ЩИТОПОДІБНОЇ ЗАЛОЗИ У ХВОРИХ НА ТИРЕОТОКСИКОЗ
Authors: Shidlovskyі V. O. , Petrunko T. R.
Published: February 2019

Тиреотоксикоз (ТТ) є різного генезу і буває при автоімунному (деструктивному) тиреоїдиті (АІТ), вузловому (ВТЗ) та дифузному (ДТЗ) токсичному зобі. Патогенез розвитку ТТ при цих захворюваннях відрізняється, що дозволяє установлювати причини його розвитку й обґрунтовувати патогенетичне лікування.

Мета дослідження – вивчити показники тиреотропного гормону, антитіл до його рецепторів та до тиреопероксидази у хворих із різними клініко-патогенетичними формами тиреотоксикозу.

Матеріали і методи. Було обстежено 94 хворих на тиреотоксикоз віком від 19 до 61 року. Серед них – 14 чоловіків і 80 жінок.

Обстеження проводили у сертифікованій лабораторії “Сінево” при первинному зверненні пацієнтів на лікування. Статистичні дослідження виконували за комп’ютерною програмою “Статистика”.

Результати досліджень та їх обговорення. Проведені дослідження дозволили оцінити гормональну функцію залози у хворих із різними клініко-патогенетичними формами тиреотоксикозу. Ми встановили, що рівень тиреотропного гормону (ТТГ) в пацієнтів усіх із тиреотоксикозом є низьким і не залежить від клініко-патогенетичної форми. При визначенні тяжкості тиреотоксикозу орієнтовне значення має рівень тироксину в крові. Зі збільшенням його вмісту тяжкість тиреотоксикозу наростає, що підтверджується даними дослідження у пацієнтів із дифузним токсичним зобом (ДТЗ) і вузловим токсичним зобом (ВТЗ).
КЛІНІЧНИЙ ВИПАДОК РОЗВИТКУ ІНФАРКТУ (НЕКРОЗУ) МІОКАРДА 2 ТИПУ, ІНДУКОВАНОГО ПРИЙОМОМ АНАБОЛІЧНИХ СТЕРОЇДІВ ТА БЕТА-АДРЕНОСТИМУЛЯТОРІВ
Authors: Shved M. I. , Kovbasa N. M. , Sadliy L. V. , Vivchar N. M. , Prokopovych O. A.
Published: February 2019

Факторами ризику та тригерами інфаркту міокарда (ІМ) у молодих людей можуть бути не традиційні серцево-судинні, а й інші причини, такі, як коронароспазм, зловживання наркотичними та іншими токсичними засобами (екзогенні глюкокортикоїди, анаболічні стероїди, β-адреностимулятори тощо), що пов’язано з активною рекламою бодібілдингу та препаратів, які сприяють нарощуванню м’язової маси і спалюванню жиру.

Мета дослідження – підвищити увагу та мотивацію лікарів до своєчасної діагностики та адекватного лікування інфаркту (некрозу) міокарда 2 типу на тлі прийому високих доз анаболічних стероїдів та β-адреностимуляторів.

Матеріали і методи. Проаналізовано клінічний випадок пацієнта з інфарктом міокарда на тлі прийому анаболічних стероїдів та β2-агоністів.

Результати досліджень та їх обговорення. Особливістю клінічних проявів, діагностики та лікування такого інфаркту (некрозу) міокарда 2 типу є наявність не лише інфарктоподібних електрокардіографічних змін, а й те, що початок хвороби проявляється нетиповим, “стертим” ангінозним синдромом на тлі гіпердинамічного синдрому (вираженої тахікардії та підвищеного систолічного артеріального тиску) й ознак гіперсимпатикотонії. Диференційно-діагностичними критеріями в таких випадках можуть бути інфарктоподібна елевація сегмента ST, але без реципрокності змін, відсутність локальних зон гіпо- та акінезів за даними ЕхоКГ, а також детальне з’ясування факторів ризику та можливих тригерів некротичних змін в міокарді. “Золотим стандартом” для диференційної діагностики в таких випадках вважають контрастну коронароангіовентрикулографію.

Висновки. Неконтрольований прийом пацієнтами молодого віку анаболічних стероїдів та β-адреностимулювальних засобів суттєво підвищує у них серцево-судинний ризик та може бути тригером розвитку зон некрозів міокарда (ІМ 2 типу). Лікування інфаркту міокарда унаслідок передозування β2-агоністів (зокрема кленбутиролу) повинно включати прийом β-адреноблокаторів в адекватних дозах, а також дезінтоксикаційну та антигістамінну терапію, що дозволяють досягти швидкого клінічного ефекту і попередити розвиток життєво небезпечних ускладнень.
A performance do comediante Whindersson Nunes
Authors: Souza Fabíola Carolina de , Medeiros Fernanda Faria , Santana Paulo Henrique Basílio
Published: February 2019

O artigo visa analisar a imagem de Whindersson Nunes como um tipo específico de celebridade, a partir dos conceitos de performance (SCHECHNER, 2003; GOFFMAN, 2010) e celebridades ordinárias (SERELLE, 2015). Através da operacionalização dos 48 SIGNOS DO CONSUMO ‍‍Fabíola Carolina de Souza et al. conceitos, o trabalho pretende sublinhar as formas como o youtuber performa a própria imagem na mídia, a fim de alcançar estratégias e valores que movimentam a dinâmica social. Por fim, os resultados indicam que há representação de papéis sociais de forma consciente e articulada.
Effect of Coronary Anatomy and Myocardial Ischemia on Long-Term Survival in Patients with Stable Ischemic Heart Disease
Authors: Weintraub William S. , Hartigan Pamela M. , Mancini G.B. John , Teo Koon K. , Maron David J. , Spertus John A. , Chaitman Bernard R. , Shaw Leslee J. , Berman Daniel , Boden William E. ,   on behalf of the COURAGE Trial Investigators
Published: February 2019

Background:

The severity of coronary artery disease (CAD) and of ischemia are evaluated to guide therapy, but their relative prognostic importance remains uncertain. Accordingly, we sought to clarify their association with long-term survival in the COURAGE trial (Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation).

Methods and Results:

Survival data from after the original trial period ended was obtained at 15 Veterans Affairs sites and 13 of 18 United States non–Veterans Affairs sites. Date of death was obtained from the Veterans Affairs system-wide Corporate Data Warehouse and the National Death Index. Of the original 2287 patients in COURAGE, 1370 (60%) had both stress perfusion imaging and quantitative coronary angiography available, with extended survival evaluated in 767 subjects. Survival was calculated by the Kaplan–Meier method, and a Cox proportional-hazards model adjusted for baseline differences. There were 369 all-cause deaths during a median follow-up of 7.9 years (range, 0–15 years). The number of coronary arteries diseased predicted survival (HR, 1.25; 95% CI, 1.09–1.43), whereas severity of ischemia did not (HR, 0.99; 95% CI, 0.80–1.22). Percutaneous coronary intervention did not offer a survival advantage over optimal medical therapy (HR, 0.95; 95% CI, 0.77–1.16) and there was no interaction between therapeutic strategy and number of coronary arteries diseased or severity of ischemia. In fully adjusted models, the number of coronary arteries diseased was not associated with increased mortality.

Conclusions:

In univariate analysis, the number of coronary arteries diseased predicted long-term mortality, but severity of ischemia did not. Adjusted for baseline variables, neither assessment approach predicted mortality. Overall, there was no survival benefit from percutaneous coronary intervention in any subset defined by either angiographic or ischemic severity.

Clinical Trial Registration:

URL:
https://www.clinicaltrials.gov
. Unique identifier: NCT00007657.
A History of Theory and Method in the Study of Religion and Dance
Authors: LaMothe Kimerer L.
Published: February 2019

The relationship between religion and dance is as old as humankind. Contemporary methods for studying this relationship date back a century. The difference between these two time frames is significant: scholars are still developing theories and methods capable of illuminating this vast history that take account of their limited place within it. A History of Theory and Method in the Study of Religion and Dance takes on a primary challenge of doing so: overcoming a conceptual dichotomy between “religion” and “dance” forged in the colonial era that justified western Christian hostility towards dance traditions across six continents over six centuries. Beginning with its enlightenment roots, LaMothe narrates a selective history of this dichotomy, revealing its ongoing work in separating dance studies from religious studies. Turning to the Bushmen of the African Kalahari, LaMothe introduces an ecokinetic approach that provides scholars with conceptual resources for mapping the generative interdependence of phenomena that appear as “dance” and/or “religion.”
Cortinarius subcaesiobrunneus sp. nov., (Cortinariaceae, Agaricales) a new species from northwest China
Authors: XIE MENGLE , LI DAN , WEI SHENGLONG , JI RUIQING , LI YU
Published: February 2019

A new species, Cortinarius subcaesiobrunneus was collected from Gansu Qilianshan National Nature Reserve, Gansu province, northwest China. It differs from other species in section Brunnei, subgenus Telamonia by the strong bluish tints at the stipe base, large basidiospores and at least 12 substitutions and indel positions in the internal transcribed spacer (ITS) region.
A survey of morphological variation in adult Meristogenys amoropalamus (Amphibia, Anura, Ranidae), with a description of a new cryptic species
Authors: SHIMADA TOMOHIKO , MATSUI MASAFUMI , YAMBUN PAUL , SUDIN AHMAD
Published: February 2019

Previous analyses of molecular and larval morphology have suggested that Meristogenys amoropalamus is composed of two cryptic species, but no diagnostic characters of their adult morphology have been reported. Here, we compared adult characters of these two species and found that they differed in iris colour (yellowish-green and sandy brown), tympanum size and relative limb length. Based on the results of analysis of DNA sequences of the type specimens and a discriminant analysis using 18 morphological variables, we conclude that the lineage with green irises is the true M. amoropalamus, and that the lineage with sandy brown irises is a new species, M. dyscritus sp. nov. In northern Sabah, M. dyscritus is distributed in altitudes lower than those of M. amoropalamus, but the distributional ranges of their larvae overlap in some streams. Meristogenys amoropalamus has larger and lighter-coloured ova, smaller clutch sizes and a more interstitial larval life than M. dyscritus. These differences suggest that M. amoropalamus has a more cryptic life during its larval period than M. dyscritus.
Acanthurus tractus Poey, 1860, a valid western Atlantic species of surgeonfish (Teleostei, Acanthuridae), distinct from Acanthurus bahianus Castelnau, 1855
Authors: BERNAL MOISÉS A. , ROCHA LUIZ A.
Published: February 2019

The ocean surgeonfish, Acanthurus bahianus, has been historically recorded from Bermuda and Massachusetts to southern Brazil and the islands of the central Atlantic. We have found that individuals in the southwestern and central Atlantic consistently have a posterior bright yellow margin on the caudal fin and an orange/red margin on the dorsal fin. This coloration is different from the characteristic white/blue fin margins on individuals from the northwestern Atlantic. In addition, there is a clear genetic distinction (d= 2.4% mtDNA, CytB) between these two lineages. With the corroborating coloration and genetic differences, we suggest that these two lineages represent distinct species. The South Atlantic species retains the name of A. bahianus and we propose to resurrect A. tractus (Poey 1860) as the valid name for the northwestern Atlantic species.
The Calliopsis (Hymenoptera; Andrenidae; Panurginae) of Chile with the description of a new species
Authors: DUMESH SHEILA , PACKER LAURENCE
Published: February 2019

Calliopsis rigormortis Dumesh & Packer, new species is described from high altitude in Maule Province in central Chile. It appears to be an Adesmia (Fabaceae) specialist and its specific name refers to its death posture which is similar to that found in other small bees that visit the same genus of plant. A key to the Chilean species of the genus is provided.
New Cardiodactylus species from unsuspected places in Southeast Asia (Orthoptera, Grylloidea, Eneopterinae)
Authors: ROBILLARD TONY
Published: February 2019

Two new species of Cardiodactylus crickets are described from unsuspected places in Southeast Asia: C. singapura n. sp., from within the island-city of Singapore, and C. thailandia n. sp. from Thailand. Descriptions focus on male and female genitalia, forewing venation and coloration. Data are provided for C. singapura n. sp. fine-scaled habitat and calling song. Consequences in terms of distribution of the genus and conservation are discussed.
A new species of southern African pollen beetle and discussion of the taxonomic position of Jelinekigethes Audisio & Cline, 2009 (Coleoptera: Nitidulidae: Meligethinae)
Authors: AUDISIO PAOLO , CLINE ANDREW RICHARD , MANCINI EMILIANO , TRIZZINO MARCO , LAMANNA FRANCESCO , ANTONINI GLORIA
Published: February 2019

The pollen-beetle Jelinekigethes dichromus n. sp. from northern South Africa is described. The new species is closely related to the other known species of this genus, J. danielssoni (Audisio 1995) from southwestern South Africa. The taxonomic position of Jelinekigethes is discussed in the context of presumably related African and Oriental meligethine genera. Larval host plants of both species of Jelinekigethes remain unknown, although important cues suggest a relationship of J. danielssoni with the problematic and isolated family Montiniaceae.
A exceptionally-preserved new species of Barchaboilus (Orthoptera: Prophalangopsidae) from the Middle Jurassic of Daohugou, China
Authors: GU JUN-JIE , QIAO GE-XIA , REN DONG
Published: February 2019

A new species of Prophalangopsidae, Bacharboilus lii sp. nov., is described. It was collected from the Middle Jurassic Jiulongshan Formation of Daohugou Village, Ningcheng County, Chifeng City, Inner Mongolia, China. This exquisitely preserved specimen exhibits clear wing venation and head structures, especially the mouthpart morphology. The stout mandibles bear well defined molar dentes which indicate an herbivorous feeding habit.
A new synonym, a new male description and new geographical records for three Ceraeochrysa species (Neuroptera: Chrysopidae)
Authors: SOSA FRANCISCO , DE FREITAS SERGIO
Published: February 2019

Ceraeochrysa Adams is the largest genus in Chrysopini with 62 valid species distributed in the New World. The taxonomy of this group is complex and largely based on male genitalic characters. There are still serious complications, especially with the species that have been described solely from female specimens. The male of C. montoyana (Navás, 1913), unknown previously, is herein described for the first time, and compared with its closest relative, C. claveri (Navás, 1911). Ceraeochrysa acutipuppis Adams & Penny, 1985 is designated as a junior synonym of C. fairchildi (Banks, 1946) based on the evidence that both species share external morphological features uncommon in other species of the genus. The species C. claveri, C. fairchildi and C. montoyana are recorded from Venezuela for the first time. External morphology and genitalia of these insects are described and illustrated.
Ochthebius ustaoglui sp. nov. (Coleoptera: Hydraenidae), a new species of the O. metallescens group from Turkey
Authors: TOPKARA E. TARIK , JÄCH MANFRED , KASAPOĞLU AHMET
Published: February 2019

To date, 73 species of Ochthebius Leach, 1815 have been reported from Turkey. Twenty-seven of these species are endemic to Turkey (Ertorun, Jäch, Kasapoğlu & Darilmaz, in prep.). During faunistic surveys in Erzurum and Denizli, a new species of the Ochthebius metallescens species group was discovered. In the present paper, the new species is described, illustrated, and notes on its habitat and distribution are provided.
First records of the leafhopper genus Ossuaria Dworakowska in China (Hemiptera: Cicadellidae: Typhlocybinae: Erythroneurini) with descriptions of two new species
Authors: ZHANG YALIN , YANG MEIXIA
Published: February 2019

Ossuaria Dworakowska is recorded for the first time from China and two new species, Ossuaria sichuanensis sp. nov. and Ossuaria yunnanensis sp. nov. are described from China. Generic characteristics and a key to known species of the genus are provided.
Description of the immature stages and redescription of the adults of Culex (Culex) lahillei Bachmann & Casal (Diptera: Culicidae)
Authors: LAURITO MAGDALENA , ALMIRÓN WALTER RICARDO , ROSSI GUSTAVO CARLOS
Published: February 2019

The pupa and fourth-instar larva of Culex (Culex) lahillei Bachmann & Casal are described and illustrated for the first time and the adults redescribed. Information is provided on the distribution, bionomics and taxonomy of the species.
New species and records of Antillocladius Sæther and Litocladius Mendes, Andersen et Sæther from Brazil and Costa Rica (Chironomidae: Orthocladiinae)
Authors: MENDES HUMBERTO F. , ANDERSEN TROND , HAGENLUND LINN K.
Published: February 2019

Antillocladius anandae sp. n., A. itatiaia sp. n. and Litocladius neusae sp. n. from Brazil, and L. chavarriai sp. n. from Costa Rica are described and illustrated as males. In addition, new records of A. antecalvus Sæther, A. arcuatus Sæther, A. brazuca Mendes et Andersen, A. folius Mendes, Andersen et Sæther, A. musci Mendes, Andersen et Sæther and Litocladius floripa Mendes et Andersen are given. Including the new species described below Antillocladius Sæther now comprises 27 species from the Neotropical, Nearctic and Oriental zoogeographical regions, while Litocladius Mendes, Andersen et Sæther comprises 5 species from the Neotropical region.
Revision of the leafhopper genus Onukigallia Ishihara, 1955 (Hemiptera: Cicadellidae: Megophthalminae)
Authors: ZHANG BIN
Published: February 2019

The megophthalmine leafhopper genus Onukigallia Ishihara is revised. Five species of this genus occurring in the Palearctic and Oriental Regions are recognized, including one new species, Onukigallia matsumurai sp. nov., described from Yunnan Prov., China. Four other known species: O. arisana (Matsumura), O. fanjingensis Zhang & Li, O. onukii (Matsumura) and O. tenuis (Matsumura) are also diagnosed. A key to species of Onukigallia based on males is provided.
A new species of the Neotropical genus Itatingamyia Albuquerque (Diptera: Muscidae)
Authors: HASEYAMA KIRSTERN L. F. , DE CARVALHO CLAUDIO J. B.
Published: February 2019

Itatingamyia (Muscidae: Diptera) was known from a single species and eight specimens. This paper describes a new species, Itatingamyia couriae sp. nov. (Santa Teresa, Espírito Santo, Brazil), and provides an identification key for the two species of Itatingamyia.
Oriental Teratomyzidae (Diptera: Schizophora)
Authors: PAPP LÁSZLÓ
Published: February 2019

The Oriental Teratomyzidae (Diptera) are reviewed. Teratomyza formosana sp. nov. is described and compared to T. chinica Yang. Poecilovitila gen. nov. (type species: P. elegans sp. nov.), a genus related to Vitila McAlpine & Keyzer is described, and includes eleven new species P. barbata sp. nov., P. brevicornis sp. nov., P. bulbiscapus sp. nov., P. defecta sp. nov., P. elegans sp. nov., P. erugata sp. nov., P. hindustanica sp. nov., P. japonica sp. nov., P. taiwanica sp. nov., P. thaii sp. nov., P. variegata sp. nov.).
First record and a new species of Megarthrus Curtis (Coleoptera, Staphylinidae, Proteininae) from the Colombian Central Andes
Authors: LÓPEZ-GARCÍA MARGARITA M. , Méndez-Rojas DIANA M. , NAVARRETE-HEREDIA JOSÉ LUÍS
Published: February 2019

The genus Megarthrus Curtis 1829 with about 139 species described around the world, is the largest of the subfamily Proteininae (Coleoptera: Staphylinidae) (Cuccodoro 2011). Megarthrus is distributed worldwide (Cuccodoro 1999) but it is apparently more diverse in the Holartic region (Navarrete-Heredia et al. 2002). However, the South American fauna is underestimated because many of the collected specimens are not yet described (Cuccodoro 2011). Newton et al. (2005) cited the genus as probable in Colombia because some species are known from Central America and northern South America, but until now, no species has been published from Colombia. Therefore, M. andinus sp. nov. represents the first record of the genus and subfamily for this country.
Revision of the genus Omalaspis Giraud, 1860 (Hym.: Figitidae: Aspicerinae)
Authors: ROS-FARRÉ P. , PUJADE-VILLAR J.
Published: February 2019

Omalaspis Giraud, 1860, is a genus of Aspicerinae (Hymenoptera: Cynipoidea: Figitidae) with a Holarctic distribution. The diagnostic characters that differentiate Omalaspis from morphologically similar genera are described. From the thirteen known species of Omalaspis only O. cavroi (Hedicke, 1914), O. latreillii (Hartig, 1840), O. norica Giraud, 1860 and O. orientalis Belizin, 1968 are valid species. All these species are redescribed. Omalaspis nigra (Hartig, 1840) and O. abnormis (Kieffer, 1901) are synonymized with O. norica, and O. ruficornis Thomson, 1877 is synonymized with O. latreilli. Omalaspis laevis Hedicke, 1914 belongs to Xyalaspis, O. davydovi Belizin, 1927 is considered as ‘incertae sedis’ and O. carinata (Kieffer 1901) ‘species dubia’. Three species are considered as species inquirenda: Omalaspis femoralis Ionescu, 1963 (which belongs to Diapriidae), O. convexa Kierych, 1985 and O. sulcata (Kieffer, 1901). Six new species are described: O. asiatica Ros-Farré & Pujade-Villar n. sp., O. brandaoi Pujade-Villar & Ros-Farré n. sp., O. curvilineata Ros-Farré & Pujade-Villar n. sp., O. gibsoni Ros-Farré & Pujade-Villar n. sp., O. niponica Ros-Farré & Pujade-Villar n. sp. and O. villemantae Pujade-Villar & Ros-Farré n. sp. The diagnostic characters of all species are illustrated and a key to differentiate them is given. A new character is defined here exclusive to Omalaspis within the Aspicerinae, the supratorular impression.
Species of the genus Eurydema (Hemiptera: Heteroptera: Pentatomidae) in Far East Asia: An integrated approach using morphological, molecular, and data crossing analyses for taxonomy
Authors: JUNG SUNGHOON , KERZHNER IZYASLAV M. , LEE SEUNGHWAN
Published: February 2019

In a revision of four previously described species of the genus Eurydema in Far East Asia, we confirm only two species, one of which consists of two subspecies: E. dominulus (Scopoli 1763) [= E. pulchra (Westwood 1837), syn. nov.], E. gebleri gebleri Kolenati 1846, and E. gebleri rugosa Motschulsky 1861 [stat. nov.]. In order to prove the above taxonomic changes, we focused on three major analyses; (1) morphological study (color patterns), (2) molecular identification (DNA barcording) and (3) cross–breeding (inter–specific copulation, fertilization). The results of these analyses were sufficient to confirm the new taxonomic changes. According to the cross–breeding analysis, interspecific copulation between males of E. dominulus (= E. pulchra) and females of E. g. gebleri or E. g. rugosa occurs in nature, but the eggs laid by the interspecific copulation were unfertilized. Two subspecies, E. g. rugosa and E. g. gebleri, preserve their own unique coloration patterns; this was confirmed by the results of intra–subspecific copulation and breeding. However, the 1 st progeny from the inter–subspecific copulation of E. g. rugosa♂ X E. g. gebleri♀ (or E. g. gebleri♂ X E. g. rugosa♀) were confirmed to have the coloration patterns inherited from E. g. gebleri.
A new large and colorful skink of the genus Amphiglossus from Madagascar revealed by morphology and multilocus molecular study
Authors: MIRALLES AURÉLIEN , RASELIMANANA ACHILLE P. , RAKOTOMALALA DOMOINA , VENCES MIGUEL , VIEITES DAVID R.
Published: February 2019

We describe a new species of Amphiglossus skink from the western edge of the Central Highlands of Madagascar in the Reserve of Makira, and also found in the Réserve Spéciale of Ambohijanahary and in the Réserve Spéciale of Marotandrano. Amphiglossus meva n. sp. is characterized and differentiated from other species of the genus by a combination of morphological, chromatic and molecular characters: 1) a relatively large size (SVL of adults from 126 to 150 mm); 2) a characteristic pattern of coloration, Amphiglossus meva being the only skink in Madagascar together with Amphiglossus crenni with dark grey dorsum contrasting with orange flanks and ventrum; 3) the absence of a postnasal scale; 4) the presubocular frequently absent, 5) the presence of single elongated tertiary temporal bordering lower secondary temporal and 6) pentadactyl limbs. In addition to the morphological approach, a multi-locus genetic analysis based on eight mitochondrial and nuclear genes clearly supports the distinctiveness of A. meva. This new species was found in areas of rainforest, sometimes containing transitional deciduous forest elements. It was typically observed under large rotten logs associated with dense layers of decomposed wood retaining certain humidity and providing habitat for invertebrate larvae and termites.