bluuebunny/crossref_metadata_2025 huggingface dataset:
Predictors of Surgical Intervention for Pediatric Acute Rhinosinusitis with Periorbital Infection
Authors: Wu Pei-Wen , Lin Yen-Ling , Lee Yun-Shien , Chiu Cheng-Hsun , Lee Ta-Jen , Huang Chien-Chia
Published: July 2022

Background: Medical versus surgical management of pediatric periorbital infection secondary to acute bacterial rhinosinusitis (ABRS) can be a dilemma for clinicians. This study aimed to evaluate the prognostic factors related to the need for surgical drainage and to help direct management decisions. Methods: Children admitted for periorbital infection secondary to ABRS between 2001 and 2019 were retrospectively reviewed. Demographics, clinical presentations, laboratory data, comorbidities, and computed tomography results were collected from medical records. Results: A total of 141 pediatric patients were enrolled. Forty-two patients (29.8%) required surgical intervention. Multivariate logistic regression analysis identified that delayed initiation of intravenous antibiotics from the onset of periorbital swelling (odds ratio [OR] = 1.94; p < 0.001) and proptosis at initial presentation (OR = 6.63; p = 0.008) were significantly associated with the need for surgical intervention. A C-reactive protein value of > 55.73 mg/L and initiation of intravenous antibiotic treatment > 2 days from the onset of periorbital swelling showed the best predictive power for surgery. Conclusions: Pediatric patients with delayed initiation of intravenous antibiotic treatment and initial presentation of proptosis had worse outcomes and required surgical intervention.
Current Effective Therapeutics in Management of COVID-19
Authors: Atluri Kavya , Aimlin Iris , Arora Shitij
Published: July 2022

The current pandemic due to the SARS-CoV-2 virus has caused irreparable damage globally. High importance is placed on defining current therapeutics for Coronavirus Disease 2019 (COVID-19). In this review, we discuss the evidence from pivotal trials that led to the approval of effective therapeutics in the treatment and prevention of COVID-19. We categorize them as effective outpatient and inpatient management strategies The review also attempts to contextualize the efficacy of therapeutics to the emerging variants. Vaccines, which remain the most effective prevention against hospitalization and deaths is not included in this review.
Axillary Web Syndrome in Breast Cancer Women: What Is the Optimal Rehabilitation Strategy after Surgery? A Systematic Review
Authors: Lippi Lorenzo , de Sire Alessandro , Losco Luigi , Mezian Kamal , Folli Arianna , Ivanova Mariia , Zattoni Lorenzo , Moalli Stefano , Ammendolia Antonio , Alfano Carmine , Fusco Nicola , Invernizzi Marco
Published: July 2022

Background: Axillary web syndrome (AWS) is one of the most prevalent and underrecognized disorders affecting breast cancer (BC) women. However, the optimal therapeutic strategy to manage AWS is far from being fully characterized. Therefore, this systematic review aims to provide a broad overview of the available rehabilitation treatments in this burdensome condition. Methods: On 13 January 2022, PubMed, Scopus, Web of Science, Cochrane, and PEDro were systematically searched for clinical studies assessing rehabilitation interventions in post-surgical BC women with AWS. The outcomes analyzed were pain, AWS clinical resolution, upper limb function, and health-related quality of life (HR-QoL). Results: The search identified 1115 records, of which 11 studies were included. A total of 174 patients were assessed (ages ranging from 37 and 66 years old). The interventions included manual lymphatic drainage, manual therapy, stretching, resistance training, mobilization techniques, and Kinesio tape. Positive improvements were reported in terms of pain relief (in 7 studies), AWS clinical resolution (in 9 studies), upper limb function (in 10 studies), and HR-QoL (in 2 studies). Conclusions: Our findings suggest that rehabilitation might be considered an effective therapeutic strategy in AWS patients. Further RCTs are needed to characterize the optimal rehabilitative interventions.
Influence of Exposure Parameters and Implant Position in Peri-Implant Bone Assessment in CBCT Images: An In Vitro Study
Authors: Sawicki Paweł , Regulski Piotr , Winiarski Artur , Zawadzki Paweł J.
Published: July 2022

The aim of this study was to assess the impact of dimensional distortion and its changes with modification of exposure setting parameters on the measurements of peri-implant bone margin. Ten titanium dental implants (InKone Primo, Global D, Paris, France) were placed in two prepared bovine ribs. Two bone models and an implant-with-transfer model were scanned with 3shape E4 (3shape, Copenhagen, Denmark) laboratory scanner. Cone beam computed tomography (CBCT) images of two bone models were taken with different values of voltage (60, 70, 80, 90 kV), tube current (4, 10 mA) and voxel size (200, 300 µm). All the data were superimposed using planning software, and the measurements of buccal bone thickness in two selected regions were performed both using CBCT and scan cross-sections. The mean squared error (MSE) being the squared differences between measurements was used in the accuracy assessment of the CBCT device. A one-way ANOVA revealed significant differences between voltage and MSE (p = 0.044), as well as implant position and MSE (p = 0.005). The distortions of measurements depend on bone margin thickness, and the higher the distance to measure, the higher the error. Accurate measurements of buccal bone thickness (MSE below 0.25) were achieved with voltage values of 70, 80, and 90 kV.
Optimization of Carpal Tunnel Syndrome Using WALANT Method
Authors: Segal Kathryn R. , Debasitis Alexandria , Koehler Steven M.
Published: July 2022

As surgical management of carpal tunnel release (CTR) becomes ever more common, extensive research has emerged to optimize the contextualization of this procedure. In particular, CTR under the wide-awake, local-anesthesia, no-tourniquet (WALANT) technique has emerged as a cost-effective, safe, and straightforward option for the millions who undergo this procedure worldwide. CTR under WALANT is associated with considerable cost savings and workflow efficiencies; it can be safely and effectively executed in an outpatient clinic under field sterility with less use of resources and production of waste, and it has consistently demonstrated standard or better post-operative pain control and satisfaction among patients. In this review of the literature, we describe the current findings on CTR using the WALANT technique.
Obesity and HFpEF
Authors: Clemenza Francesco , Citarrella Roberto , Patti Angelo , Rizzo Manfredi
Published: July 2022

Heart failure with preserved ejection fraction (HFpEF) has represented a therapeutic challenge in recent decades [...]
The Impact of the SARS-CoV-2 Pandemic on the Needs of Non-Infected Patients and Their Families in Palliative Care—Interviews with Those Concerned
Authors: Gerlach Christina , Ullrich Anneke , Berges Natalie , Bausewein Claudia , Oechsle Karin , Hodiamont Farina ,   on behalf of the PallPan Study Group
Published: July 2022

During humanitarian crises, such as a pandemic, healthcare systems worldwide face unknown challenges. This study aimed to explore and describe the effect of the SARS-CoV-2 pandemic on the needs of non-infected patients and family caregivers in specialist palliative care, using qualitative, semi-structured interviews. Data were analyzed using inductive content analysis, following the framework approach. Thirty-one interviews were conducted with patients/family caregivers (15/16) in palliative care units/specialist palliative home care (21/10) from June 2020 to January 2021. Well-known needs of patients and family caregivers at the end of life remained during the pandemic. Pandemic- dependent themes were (1) implications of the risk of contagion, (2) impact of the restriction of social interactions, (3) effects on the delivery of healthcare, and (4) changes in the relative’s role as family caregiver. Restriction on visits limited family caregivers’ ability to be present in palliative care units. In specialist palliative home care, family caregivers were concerned about the balance between preserving social contacts at the end of life and preventing infection. Specialist palliative care during a pandemic needs to meet both the well-known needs at the end of life and additional needs in the pandemic context. In particular, attention should be given to the needs and burden of family caregivers, which became more multifaceted with regards to the pandemic.
Effect of Iron Depletion by Bloodletting vs. Observation on Oxidative Stress Biomarkers of Women with Functional Hyperandrogenism Taking a Combined Oral Contraceptive: A Randomized Clinical Trial
Authors: Luque-Ramírez Manuel , Ortiz-Flores Andrés E. , Martínez-García María Ángeles , Insenser María , Quintero-Tobar Alejandra , De Lope Quiñones Sara , Fernández-Durán Elena , Nattero-Chávez María Lía , Álvarez-Blasco Francisco , Escobar-Morreale Héctor Francisco
Published: July 2022

Women with functional hyperandrogenism show both increased markers of oxidative stress and a mild iron overload. Combined oral contraceptives (COC) may worsen redox status in the general population. Since iron depletion ameliorates oxidative stress in other iron overload states, we aimed to address the changes in the redox status of these women as a consequence of COC therapy and of bloodletting, conducting a randomized, controlled, parallel, open-label clinical trial in 33 adult women with polycystic ovary syndrome or idiopathic hyperandrogenism. After three months of treatment with a COC, participants were randomized (1:1) to three scheduled bloodlettings or observation for another nine months. After taking a COC, participants showed a mild decrease in their plasma electrochemical antioxidant capacity, considering fast-acting antioxidants [MD: −1.51 (−2.43 to −0.60) μC, p = 0.002], and slow-acting antioxidants [MD: −1.90 (−2.66 to −1.14) μC, p < 0.001]. Women submitted to bloodletting showed a decrease in their non-enzymatic antioxidant capacity levels (NEAC) throughout the trial, whereas those individuals in the control arm showed a mild increase in these levels at the end of the study (Wilks’ λ: 0.802, F: 3.572, p = 0.041). Decreasing ferritin and plasma hemoglobin during the trial were associated with worse NEAC levels. COC may impair redox status in women with functional hyperandrogenism. Decreasing iron stores by scheduled bloodletting does not override this impairment.
Galectin 3 (LGALS3) Gene Polymorphisms Are Associated with Biochemical Parameters and Primary Disease in Patients with End-Stage Renal Disease in Serbian Population
Authors: Kovacevic Zoran , Lazarevic Tatjana , Maksimovic Nela , Grk Milka , Volarevic Vladislav , Gazdic Jankovic Marina , Djukic Svetlana , Janicijevic Katarina , Miletic Kovacevic Marina , Ljujic Biljana
Published: July 2022

Galectin 3 plays a significant role in the development of chronic renal failure, particularly end-stage renal disease (ESRD). The aim of our study was to investigate the association between Gal-3 and biochemical parameters and primary disease in ESRD patients, by exploring the polymorphisms LGALS3 rs4644, rs4652, and rs11125. A total of 108 ESRD patients and 38 healthy controls were enrolled in the study. Genotyping of LGALS3 gene rs4644, rs4652, and rs11125 polymorphisms was performed by polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP). By multivariate logistic regression analysis, we found that LGALS3 rs4644 CC and rs4652 AA genotypes were significantly associated with a higher risk for lower hemoglobin, higher level of parathyroid hormone, and also occurrence of diabetes mellitus and arterial hypertension. The CAA haplotype was significantly more common in patients with diabetes, low hemoglobin level, and normal PTH level. It has been observed as well that the ACT haplotype was more common in patients with low glomerular filtration, low PTH, and normal hemoglobin level. We found that the LGALS3 rs4644 and rs4652 gene polymorphism may be involved in the pathogenesis and appearance of complications in ESRD patients and thus could be considered a new genetic risk factor in this population.
Medications as a Trigger of Sleep-Related Eating Disorder: A Disproportionality Analysis
Authors: Merino Diane , Gérard Alexandre O. , Van Obberghen Elise K. , Ben Othman Nouha , Ettore Eric , Giordana Bruno , Viard Delphine , Rocher Fanny , Destere Alexandre , Benoit Michel , Drici Milou-Daniel
Published: July 2022

Sleep-related eating disorder (SRED) is a parasomnia with recurrent, involuntary, amnestic eating episodes during sleep. There is growing evidence of the association between SRED and medications. Therefore, we aimed to rank drugs showing the strongest association. VigiBase® (WHO pharmacovigilance database) was queried for all reports of “Sleep-related eating disorder”. Disproportionality analysis relied on the Reporting Odds Ratio, with its 95% Confidence Interval (CI), and the Information Component. Our VigiBase® query yielded 676 cases of drug-associated SRED. Reports mostly involved zolpidem (243, 35.9%), sodium oxybate (185, 27.4%), and quetiapine (97, 14.3%). Significant disproportionality was found for 35 medications, including zolpidem (387.6; 95%CI 331.2–453.7), sodium oxybate (204.2; 95%CI 172.4–241.8), suvorexant (67.3; 95%CI 38.0–119.2), quetiapine (53.3; 95%CI 43.0–66.1), and several psychostimulants and serotonin-norepinephrine reuptake inhibitors (SNRIs). Patients treated with nonbenzodiazepines or SNRIs were significantly older (mean age: 49.0 vs. 37.5; p < 0.001) and their SRED were more likely to be serious (62.6% vs. 51.4%; p = 0.014) than patients treated with sodium oxybate or psychostimulants. Psychotropic drugs are involved in almost all reports. In patients with SRED, an iatrogenic trigger should be searched for.
The Diagnostic Accuracy of Second Trimester Plasma Glycated CD59 (pGCD59) to Identify Women with Gestational Diabetes Mellitus Based on the 75 g OGTT Using the WHO Criteria: A Prospective Study of Non-Diabetic Pregnant Women in Ireland
Authors: Bogdanet Delia , Toth Castillo Michelle , Doheny Helen , Dervan Louise , Luque-Fernandez Miguel-Angel , Halperin Jose A. , O’Shea Paula M. , Dunne Fidelma P.
Published: July 2022

The aim of this study was to evaluate the ability of second trimester plasma glycated CD59 (pGCD59), a novel biomarker, to predict the results of the 2 h 75 g oral glucose tolerance test at 24–28 weeks of gestation, employing the 2013 World Health Organisation criteria. This was a prospective study of 378 pregnant women. The ability of pGCD59 to predict gestational diabetes (GDM) was assessed using adjusted ROC curves for maternal age, BMI, maternal ethnicity, parity, previous GDM, and family history of diabetes. The pGCD59 levels were significantly higher in women with GDM compared to women with normal glucose tolerance (p = 0.003). The pGCD59 generated an adjusted AUC for identifying GDM cases of 0.65 (95%CI: 0.58–0.71, p < 0.001). The pGCD59 predicted GDM status diagnosed by a fasting glucose value of 5.1 mmol/L with an adjusted AUC of 0.74 (95%CI: 0.65–0.81, p < 0.001). Analysis of BMI subgroups determined that pGCD59 generated the highest AUC in the 35 kg/m2 ≤ BMI < 40 kg/m2 (AUC: 0.84 95%CI: 0.69–0.98) and BMI ≥ 40 kg/m2 (AUC: 0.96 95%CI: 0.86–0.99) categories. This study found that second trimester pGCD59 is a fair predictor of GDM status diagnosed by elevated fasting glucose independent of BMI and an excellent predictor of GDM in subjects with a very high BMI.
Adhesion and Proliferation of Mesenchymal Stem Cells on Plasma-Coated Biodegradable Nanofibers
Authors: Manakhov Anton M. , Solovieva Anastasiya O. , Permyakova Elizaveta S. , Sitnikova Natalya A. , Klyushova Lyubov S. , Kiryukhantsev-Korneev Philipp V. , Konopatsky Anton S. , Shtansky Dmitry V.
Published: July 2022

Various biomedical applications of biodegradable nanofibers are a hot topic, as evidenced by the ever-increasing number of publications in this field. However, as-prepared nanofibers suffer from poor cell adhesion, so their surface is often modified. In this work, active polymeric surface layers with different densities of COOH groups from 5.1 to 14.4% were successfully prepared by Ar/CO2/C2H4 plasma polymerization. It has been shown that adhesion and proliferation of mesenchymal stem cells (MSCs) seeded onto plasma-modified PCL nanofibers are controlled by the CO2:C2H4 ratio. At a high CO2:C2H4 ratio, a well-defined network of actin microfilaments is observed in the MSCs. Nanofibers produced at a low CO2:C2H4 ratio showed poor cell adhesion and very poor survival. There were significantly fewer cells on the surface, they had a small spreading area, a poorly developed network of actin filaments, and there were almost no stress fibrils. The maximum percentage of proliferating cells was recorded at a CO2:C2H4 ratio of 35:15 compared with gaseous environments of 25:20 and 20:25 (24.1 ± 1.5; 8.4 ± 0.9, and 4.1 ± 0.4%, respectively). Interestingly, no differences were observed between the number of cells on the untreated surface and the plasma-polymerized surface at CO2:C2H4 = 20:25 (4.9 ± 0.6 and 4.1 ± 0.4, respectively). Thus, Ar/CO2/C2H4 plasma polymerization can be an excellent tool for regulating the viability of MSCs by simply adjusting the CO2:C2H4 ratio.
Development of Wood Polymer Composites from Recycled Wood and Plastic Waste: Thermal and Mechanical Properties
Authors: Nukala Satya Guha , Kong Ing , Kakarla Akesh Babu , Kong Win , Kong Wei
Published: July 2022

The depletion of natural resources due to the aggressive industrialization in the last decades has brought considerable attention to research aimed at developing green and sustainable products using eco-friendly materials. The purpose of the current study was to develop wood polymer composites (WPCs) using recycled plastic waste (RPW) generated from university laboratories and recycled wood waste (RWW) from construction and demolition (C&D) activities by melt-blending technique. The WPCs were characterised for their mechanical and thermal properties, as well as water uptake and morphology. The SEM micrograph indicated good interaction between RWW and RPW matrix. The mechanical strength of the WPCs was found to increase from 26.59 to 34.30 MPa, with an increase of the RWW content in the matrix. The thermal stability was higher in the composite with a higher percentage of RWW in the matrix. The wettability results indicated that the composite with a higher RWW (20%) had a higher water uptake. These results suggest that the produced WPCs can be a promising environmental-friendly material, while maintaining good mechanical, thermal, and wettability properties.
Morpho-Molecular Characterization of Microfungi Associated with Phyllostachys (Poaceae) in Sichuan, China
Authors: Zeng Qian , Lv Yi-Cong , Xu Xiu-Lan , Deng Yu , Wang Fei-Hu , Liu Si-Yi , Liu Li-Juan , Yang Chun-Lin , Liu Ying-Gao
Published: July 2022

In the present study, we surveyed the ascomycetes from bamboo of Phyllostachys across Sichuan Province, China. A biphasic approach based on morphological characteristics and multigene phylogeny confirmed seven species, including one new genus, two new species, and five new host record species. A novel genus Paralloneottiosporina is introduced to accommodate Pa. sichuanensis that was collected from leaves of Phyllostachys violascens. Moreover, the newly introduced species Bifusisporella sichuanensis was isolated from leaves of P. edulis, and five species were newly recorded on bamboos, four species belonging to Apiospora, viz. Ap. yunnana, Ap. neosubglobosa, Ap. jiangxiensis, and Ap. hydei, and the last species, Seriascoma yunnanense, isolated from dead culms of P. heterocycla. Morphologically similar and phylogenetically related taxa were compared. Comprehensive descriptions, color photo plates of micromorphology are provided.
Comparative Copper Resistance Strategies of Rhodonia placenta and Phanerochaete chrysosporium in a Copper/Azole-Treated Wood Microcosm
Authors: Pandharikar Gaurav , Claudien Kévin , Rose Christophe , Billet David , Pollier Benoit , Deveau Aurélie , Besserer Arnaud , Morel-Rouhier Mélanie
Published: July 2022

Copper-based formulations of wood preservatives are widely used in industry to protect wood materials from degradation caused by fungi. Wood treated with preservatives generate toxic waste that currently cannot be properly recycled. Despite copper being very efficient as an antifungal agent against most fungi, some species are able to cope with these high metal concentrations. This is the case for the brown-rot fungus Rhodonia placenta and the white-rot fungus Phanerochaete chrysosporium, which are able to grow efficiently in pine wood treated with Tanalith E3474. Here, we aimed to test the abilities of the two fungi to cope with copper in this toxic environment and to decontaminate Tanalith E-treated wood. A microcosm allowing the growth of the fungi on industrially treated pine wood was designed, and the distribution of copper between mycelium and wood was analysed within the embedded hyphae and wood particles using coupled X-ray fluorescence spectroscopy and Scanning Electron Microscopy (SEM)/Electron Dispersive Spectroscopy (EDS). The results demonstrate the copper biosorption capacities of P. chrysosporium and the production of copper-oxalate crystals by R. placenta. These data coupled to genomic analysis suggest the involvement of additional mechanisms for copper tolerance in these rot fungi that are likely related to copper transport (import, export, or vacuolar sequestration).
Effectiveness of More Personalized, Case-Managed, and Multicomponent Treatment for Patients with Severe Schizophrenia Compared to the Standard Treatment: A Ten-Year Follow-Up
Authors: Fernández-Miranda Juan J. , Díaz-Fernández Silvia , López-Muñoz Francisco
Published: July 2022

Case management is a model of personalized intervention in people with severe mental illness. To explore the treatment adherence and effectiveness of patients with severe schizophrenia (Clinical Global Impression Severity, CGI-S ≥ 5) undergoing treatment in a community-based, case-managed program (CMP) with an integrated pharmacological and psychosocial approach compared with the standard treatment, an observational, ten-year follow-up study was conducted on patients treated in mental health units (MHUs) or a CMP (n = 688). Treatment discontinuation, hospitalizations, suicide attempts, and antipsychotic (AP) medications were recorded. Clinical severity was assessed with the CGI-S. Adherence to the CMP was higher than adherence to standard treatment (p < 0.001). There were fewer hospitalizations and suicide attempts in the CMP (p < 0.001). The clinical severity decreased more in the CMP (p < 0.005). Long-acting injectable (LAI) antipsychotic medication was more closely related to these outcomes than oral antipsychotics (APs) were (p < 0.001). Patients with severe schizophrenia in an integrated CMP recorded higher treatment compliance and better outcomes compared with standard care. Treatment with LAI APs was linked to these outcomes. A personalized combination of case management and LAI AP medication was more effective in these patients than standard treatment and oral APs.
The Evolution of Job Lock in the U.S.: Evidence from the Affordable Care Act
Authors: Bailey James , Colman Gregory , Dave Dhaval
Published: July 2022

Since at least the early 1990s, economists have found substantial evidence of “job lock” in the United States: workers who get health insurance from their employer are less likely to switch jobs. Early work showed stronger job lock among groups that place a higher value on health insurance, whereas more recent work has focused on measuring the effect of specific policies on job lock. We combine these approaches by replicating some of the classic group comparisons (job switching among the more versus less healthy, and among those whose spouses do or do not have their own health insurance) over a much longer time period, using data from the Current Population Survey and the Medical Expenditure Panel Survey. This enables us to document the evolution of job lock over time, with a particular focus on how it changed when policies such as the Affordable Care Act (ACA) took effect. Estimates based on a difference-in-differences methodology indicate that job lock remains substantial, and that ACA has not significantly affected job mobility.
Monitoring Land-Use Efficiency in China’s Yangtze River Economic Belt from 2000 to 2018
Authors: Wang Yunchen , Li Boyan , Xu Lei
Published: July 2022

Monitoring of the indicator Sustainable Development Goal (SDG) 11.3.1 is important for understanding the coordination between land consumption rate (LCR) and population growth rate (PGR). However, the spatiotemporal indicator SDG 11.3.1 changes at the urban agglomeration (UA) level, and the relationship between LCR and PGR in the prefecture-level cities from different UAs remains unclear. In this study, we monitored the spatiotemporal indicator SDG 11.3.1 in the Yangtze River Economic Belt (YREB) and its three major UAs (i.e., Chengdu–Chongqing (CC), the Middle Reaches of the Yangtze River (MRYR), and the Yangtze River Delta (YRD)) for the periods 2000–2010, 2010–2015, and 2015–2018, using the space–time interaction (STI) method and Pearson’s method. Our major findings were as follows: (1) Compared with the world average of 1.28 for LCRPGR (i.e., ratio of LCR to PGR), except for the LCRPGR of the YRD (2000–2018) and CC (2000–2010), the LCRPGR of CC, the MRYR, and the YREB was lower than 1.28 during 2000–2018. (2) The gaps in both population and built-up area between the YREB and the three UAs did not narrow, but widened. (3) Compared with the LCRPGR in China, except for the LCRPGR of the YRD (2000–2018) and CC (2000–2010), the LCRPGR of the YREB increased from 1.21 to 1.23 between 2000–2010 and 2010–2015, and then decreased to 1.16 in 2015–2018, indicating that the relationship between LCR and PGR in the YREB is relatively stable. (4) A significant positive relationship (p < 0.001) was found between LCR and PGR in CC, the MRYR, the YRD, and the YREB. We conclude that the indicator SDG 11.3.1 is a helpful tool for evaluating land-use efficiency caused by the LCR and PGR at the UA level. Our results provide information support for promoting sustainable and coordinative development between LCR and PGR.
Perfect-Perfective Variation across Spanish Dialects: A Parallel-Corpus Study
Authors: Fuchs Martín , González Paz
Published: July 2022

To analyze crossdialectal variation between the use of a Present Perfect form (Pretérito Perfecto Compuesto) and a Perfective Past form (Pretérito Indefinido) in Spanish, we make use of two converging methodologies: (i) parallel corpus research, where we compare different translations of the same text (Harry Potter and the Philosopher’s Stone) into specific standardized written varieties of Spanish (Peninsular, Mexican, Argentinian), and (ii) an elicitation forced-choice task, where native speakers of each of the cities in which these standardized written norms are produced (Madrid, Mexico City, Buenos Aires) have to choose between the Pretérito Perfecto Compuesto and the Pretérito Indefinido as the most natural filler for a blank in contexts extracted from the novel. Results from these two tasks do not align completely. While the data from our parallel corpus work indicate a wider distribution of Perfect use in the Mexican translation than in the Peninsular and the Argentinian ones, the elicitation task shows that only the choices of the speakers of Madrid (Castilian Spanish) and Buenos Aires (Rioplatense Spanish) converge with their respective translations patterns. Since the distribution observed in the Mexican translation not only goes against the elicitation data, but also contradicts previous findings in the literature, we abandon it in further analyses. In the second part of the paper, through a detailed annotation of the Peninsular and Argentinian corpora, we show that the constraints allowing Perfect use in each of these standardized varieties respond only to some features previously advanced in the literature. While both dialects allow for experiential and resultative readings of the Pretérito Perfecto Compuesto, Castilian Spanish also prefers the use of this marker to locate an event in the hodiernal past. On the other hand, Rioplatense Spanish systematically defaults to the Pretérito Indefinido in these cases, displaying a more restricted distribution for the Perfect form. Both dialects also seem to exhibit a preference for the Pretérito Perfecto Compuesto in continuative contexts. Our work thus provides two crucial take-home messages: (i) understanding crossdialectal variation in written language is crucial for advancing crosslinguistic generalizations about tense-aspect phenomena; and (ii) combining parallel corpus and experimental methodologies can help us understand in a more thorough way the distribution of Perfect and (Perfective) Past forms across dialects.
Impact of Diabetes Duration on Clinical Outcome in Patients Receiving Rotational Atherectomy in Calcified Lesions in Korea—Results from ROCK Registry
Authors: Jung Jin , Her Sung-Ho , Lee Kyusup , Jung Ji-Hoon , Yoo Ki-Dong , Moon Keon-Woong , Moon Donggyu , Lee Su-Nam , Jang Won-Young , Choi Ik-Jun , Lee Jae-Hwan , Lee Jang-Hoon , Lee Sang-Rok , Lee Seung-Whan , Yun Kyeong-Ho , Lee Hyun-Jong
Published: July 2022

There are limited data regarding the clinical impact of diabetes duration for patients with heavy calcified coronary lesions. We sought to determine the clinical impact of diabetes duration on clinical outcomes in patients with heavily calcified lesions who required rotational atherectomy during percutaneous coronary intervention (PCI). A total of 540 diabetic patients (583 lesions) were enrolled between January 2010 and October 2019. Patients were classified into three subgroups: patients with no diabetes mellitus (non-DM), shorter duration (S-DM), and longer duration (L-DM), of which duration was divided at 10 years. During 18 months of follow-up-duration, diabetes duration was significantly associated with the primary outcome. The incidence rate of target-vessel failure (TVF), the primary outcome, was significantly higher in the L-DM group compared with non-DM or S-DM. Among secondary outcomes, any repeat revascularization (RR) was frequently observed in the L-DM compared with other groups. In multivariate analysis, the risk of TVF and any RR was 1.9 times and 2.4 times higher in L-DM than in non-DM, respectively. This study firstly demonstrated that there is an association between a longer DM duration and poor clinical outcomes in patients with severe calcified CAD after PCI. More careful monitoring for recurrence is needed during follow-up in those patients.
The Influence of Copper Content on the Elastic Modulus and Antibacterial Properties of Ti-13Nb-13Zr-xCu Alloy
Authors: Mao Xinru , Shi Anqi , Wang Renxian , Nie Jingjun , Qin Gaowu , Chen Dafu , Zhang Erlin
Published: July 2022

Device-related infection or inflammatory and stress shield are still the main problems faced by titanium alloy implants for long-term implantation application; therefore, it is of great significance to design an alloy with low elastic modulus and good antibacterial properties as well as good biocompatibility. In this paper, Ti-13Nb-13Zr-xCu(x = 3, 7 wt.%) alloys were designed and prepared to reveal the influence of Cu content on the elastic modulus and antibacterial property. X-ray diffractometer, metallographic microscope, scanning electron microscope, and transmission electron microscope were used to study the phase transformation, microstructure, mechanical properties, antibacterial properties, and cytotoxicity of the alloys. The experimental results have demonstrated that the antibacterial performance and the elastic modulus were significantly improved but the corrosion resistance deteriorated with the increase of the copper content. Ti-13Nb-13Zr-3Cu with a low modulus of 73 GPa and an antibacterial rate of over 90% against Staphylococcus aureus (S. aureus) exhibited great potential as a candidate for implant titanium in the future.
Intracellular Toxic Advanced Glycation End-Products May Induce Cell Death and Suppress Cardiac Fibroblasts
Authors: Takata Takanobu , Sakasai-Sakai Akiko , Takeuchi Masayoshi
Published: July 2022

Cardiovascular disease (CVD) is a lifestyle-related disease (LSRD) induced by the dysfunction and cell death of cardiomyocytes. Cardiac fibroblasts are activated and differentiate in response to specific signals, such as transforming growth factor-β released from injured cardiomyocytes, and are crucial for the protection of cardiomyocytes, cardiac tissue repair, and remodeling. In contrast, cardiac fibroblasts have been shown to induce injury or death of cardiomyocytes and are implicated in the pathogenesis of diseases such as cardiac hypertrophy. We designated glyceraldehyde-derived advanced glycation end-products (AGEs) as toxic AGEs (TAGE) due to their cytotoxicity and association with LSRD. Intracellular TAGE in cardiomyocytes decreased their beating rate and induced cell death in the absence of myocardial ischemia. The TAGE levels in blood were elevated in patients with CVD and were associated with myocardial ischemia along with increased risk of atherosclerosis in vascular endothelial cells in vitro. The relationships between the dysfunction or cell death of cardiac fibroblasts and intracellular and extracellular TAGE, which are secreted from certain organs, remain unclear. We examined the cytotoxicity of intracellular TAGE by a slot blot analysis, and TAGE-modified bovine serum albumin (TAGE-BSA), a model of extracellular TAGE, in normal human cardiac fibroblasts (HCF). Intracellular TAGE induced cell death in normal HCF, whereas TAGE-BSA did not, even at aberrantly high non-physiological levels. Therefore, only intracellular TAGE induced cell death in HCF under physiological conditions, possibly inhibiting the role of HCF.
Renal Sinus Fat Is Expanded in Patients with Obesity and/or Hypertension and Reduced by Bariatric Surgery Associated with Hypertension Remission
Authors: Moritz Emilia , Dadson Prince , Saukko Ekaterina , Honka Miikka-Juhani , Koskensalo Kalle , Seppälä Kerttu , Pekkarinen Laura , Moriconi Diego , Helmiö Mika , Salminen Paulina , Nuutila Pirjo , Rebelos Eleni
Published: July 2022

Renal sinus fat is a fat depot at the renal hilum. Because of its location around the renal artery, vein, and lymphatic vessels, an expanded renal sinus fat mass may have hemodynamic and renal implications. We studied whether renal sinus fat area (RSF) associates with hypertension and whether following bariatric surgery a decrease in RSF associates with improvement of hypertension. A total of 74 severely obese and 46 lean controls were studied with whole-body magnetic resonance imaging (MRI). A total of 42 obese subjects were re-studied six months after bariatric surgery. RSF was assessed by two independent researchers using sliceOmatic. Glomerular filtration rate (eGFR) was estimated according to the CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration). Patients with obesity accumulated more RSF compared to lean controls (2.3 [1.7–3.1] vs. 1.8 [1.4–2.5] cm2, p = 0.03). Patients with hypertension (N = 36) had a larger RSF depot compared to normotensive subjects (2.6 [2.0–3.3] vs. 2.0 [1.4–2.5] cm2, p = 0.0007) also after accounting for body mass index (BMI). In the pooled data, RSF was negatively associated with eGFR (r = −0.20, p = 0.03), whereas there was no association with systolic or diastolic blood pressure. Following bariatric surgery, RSF was reduced (1.6 [1.3–2.3] vs. 2.3 [1.7–3.1] cm2, p = 0.03) along with other markers of adiposity. A total of 9/27 of patients achieved remission from hypertension. The remission was associated with a larger decrease in RSF, compared to patients who remained hypertensive (−0.68 [−0.74 to −0.44] vs. −0.28 [−0.59 to 0] cm2, p = 0.009). The accumulation of RSF seems to be involved in the pathogenesis of hypertension in obesity. Following bariatric surgery, loss of RSF was associated with remission from hypertension.
Investigation of the Attenuation and Release of Cu2+ Ions by Polymer-Treated Tailings
Authors: Boshrouyeh Ghandashtani Mohammad , Edraki Mansour , Baumgartl Thomas , Costine Allan , Amari Samar
Published: July 2022

This study investigated the attenuation and release behaviour of copper ions using a standard kaolin-silt slurry as the synthetic tailings in a high solids/high salinity application before and after inline flocculation. A homogenous, synthetic tailings slurry was prepared in a 0.6 M NaCl solution and treated in a low-shear mixer by adding Magnafloc® 336 flocculant. Following the evaluation of morphological properties of both the untreated (UT) and polymer-treated tailings (PT), identical equilibrium tests were performed via the bottle-point method constant concentration technique. The maximum copper ions uptake capacity of polymer-treated tailings was 25% more than the untreated slurry at the equilibrium state in a chemisorption process in which the ions had the capability of binding onto one location on the sorbent, which could be influencing other binding sites on the same sorbent. Polymer treatment resulted in a highly porous structure that exhibited an increased capacity to adsorb and retain copper ions compared to the UT materials. This behaviour indicates the strong binding between the copper ions and active site of the treated tailings particles with greater capability of this material for preserving heavy metal ions within their structure across a wide pH range (2–10) compared to the UT materials. The results advance the fundamental understanding of how inline flocculation can considerably improve the sorption capacity of high solids/high salinity tailings favouring potential long-term rehabilitation purposes at mine closure and the role of sorption and desorption of heavy metal ions’ behaviour play to achieve this goal.
Effect of Particle Size of Fly Ash Microspheres (FAMs) on the Selected Properties of Concrete
Authors: Haustein Elżbieta , Kuryłowicz-Cudowska Aleksandra
Published: July 2022

This paper presents the investigations of selected properties of concrete containing two fractions of fly ash microspheres (FAMs) with grain size up to 200 µm and up to 500 µm. Concrete mixtures with ordinary Portland cement and three substitution rates of cement by FAMs, 1.3%, 2.0%, and 2.6%, were investigated. For all concrete mixes, the constant water–binder ratio (w/b) equal to 0.50 was used. The research program included the determination of chemical composition, particle size distribution, and pozzolanic activity of FAMs. The analysis showed that the microspheres consist of three main elements: silicon, aluminum, and iron, whose oxides constitute about 89% of the material. The total content of air pores, measured in concrete at 28 days, ranges from 1.3 to 3.1% for the grain sizes below 200 µm and from 1.4% to 3.9% for the grain sizes up to 500 µm. The FAMs with a particle diameter < 200 µm have a relatively high level of activity pozzolanic at 28 days. The SEM analysis proved that the use of microspheres reduces gaps and increases the CSH phase. The compression test showed that the addition of fly ash microspheres with grain size below 200 µm increases long-term concrete strength.
Research and evaluation of the complexity of management tasks within the framework of the organization's process activities
Authors: Gerasimov B. N.
Published: July 2022

The study of the forms and content of the attributes of processes, sub-processes and their components allowed us to determine their significant role in the technologization of the main "building blocks" of the structure of the organization's management systems. Process and functional approaches defined and formed functional management tasks. The practice of managing various objects in social and economic environments made it possible to identify and justify the composition and content of management tasks: input and output information, transformation procedures, as well as methodological tools to support these procedures. Empirical studies of the content of the elements of management tasks in various processes and subprocesses have revealed a relationship between the complexity of these elements and the time of their implementation in technologies for solving management tasks. The use of this approach for designing and reforming any management attributes will allow us to move to a scientifically based rationing of the labor intensity of implementing management tasks and, as a result, affect the quality and efficiency of processes and their parts in organizations at all stages of their functioning.
The main directions of development and measures to support public-private partnership in the context of new economic sanctions
Authors: Rabadanova A. A.
Published: July 2022

The article highlights the main directions of development and measures to support public-private partnership in the context of the introduction of new anti-Russian sanctions. In the context of economic turmoil, the need to optimize and search for additional points of contact between the state and business is increasing, which can serve as a catalyst for restoring the economic balance. The article assigns the leading role to the state in partnership with business as a guarantor of state and economic security. It was noted that in the current economic situation, PPP projects for the development of the social sphere, infrastructure, IT-sphere, and tourism acquire particular relevance.
ANALISIS PENILAIAN TINGKAT KESEHATAN BUMN BERDASARKAN ASPEK KEUANGAN PADA PT TELKOM INDONESIA (PERSERO) TBK TAHUN 2016 - 2020
Authors: Muhamad Annisa , Sofiani Venita , Suherman Acep
Published: July 2022

This study aims to assess the health level of PT Telkom Indonesia (Persero) Tbk in 2016–2020 in the financial aspect based on the Decree of the Minister of BUMN Number: KEP-100/MBU/2002. The assessment based on the financial aspect uses eight indicators, namely return on equity (ROE), return on investment (ROI), cash ratio, current ratio, collection periods, inventory turnover, total asset turnover, and the ratio of equity to total assets. The research method used is a quantitative method with a descriptive type of research. Based on the results of data analysis, it shows that the level of health of PT Telkom Indonesia (Persero) Tbk based on financial aspects during 2016–2020 obtained the title of Healthy (AA) with an interval of 80 < TS <= 95. However, the total score obtained has decreased. In 2016, a total score of 93.57 was obtained. Then, in 2017, it became 92.14. Then in 2018, it became 89.29. In 2019-2020, they obtained the same total score of 86.43.
Pemodelan Regresi Logistik untuk Diagnosis Dini Infeksi Covid-19 di Indonesia
Authors: Roosyidah Nila Ayu Nur , Supriyatna Putu Krishnanda
Published: July 2022

Controlling the spread of the Covid-19 virus in Indonesia, the government continues to strive for a comprehensive 3T (Testing, Training, and Tracing) implementation. Massive testing is often constrained by several things, including cost and affordability of access. This study aims to create a model for early diagnosis of Covid-19 infection cases through several characteristic symptoms and experiences of close contact with positive patients. By using a binary logistic regression model, it was found that symptoms of anosmia, feverish symptoms, and close contact experience were significant in influencing Covid-19 infection. From the odds ratio value, it is known that anosmia is the most influential variable. Someone who has anosmia tends to be infected by 31 times compared to those who do not. Validation of the strength of the model in classifying is done by making predictions on the resulting model is good, because the measurement of each criterion of the strength of the model consists of accuracy, sensitivity, and specificity of the model both on the data testing each produces a value of 0.8 (close to 1). The area under the Receiver Operating Characteristic (ROC) curve for testing data is 0.8462, which means that the model already has good criteria for classifying.
Office of Strategy Management; conundrum and impacts in the public sector
Authors: Rashid Fairul Rizal Haji
Published: July 2022

Objective - This study intends to understand the perceived roles undertaken by the Office of Strategy Management (OSM) and the meanings of its existence in the strategy implementation process in the public sector environment.
Methodology/Technique – This research is guided by an interpretive methodology and is done through a case study on the OSM of a selected government ministry in Brunei. The primary instrument used in face-to-face interviews with departmental officers across the ministry including those from the OSM. Documentation analysis was also deployed that complemented the main research instrument.
Finding – This research indicated that the perceived roles of OSM, and its actual ability to influence the strategy implementation process, are rather limited and merely act as a secretariat body. The causal conditions found which include top management commitment, legitimacy issues, full-fledged obligation, and lack of coaching and mentoring role have led to the current state of the OSM. In consequence, the ministerial-level strategy map has become an open-ended document and the departmental scorecard is merely used as a reporting mechanism to record the core routine repetitively performed over the years.
Novelty – This study is arguably the first of its kind explored in academia in the context of the public sector domain. The study has been used and managed to contribute to the theoretical development of Institutional Theory, particularly in the New Institutional Theory of Sociology.

Type of Paper: Empirical
JEL Classification: M12, M19.
Keywords: Office of Strategy Management; Strategy Management; Performance Management; Public Sector; South East Asia.
Reference to this paper should be referred to as follows: Rashid, F.R.H. (2022). Office of Strategy Management; conundrum and impacts in the public sector, GATR-Global J. Bus. Soc. Sci. Review, 10(2), 89–103. https://doi.org/10.35609/gjbssr.2022.10.2(3)
Kreatywność w procesie uczenia się muzyki poprzez audiację we wczesnej edukacji
Authors: Zwolińska Ewa Anna
Published: July 2022

Artykuł dotyczy pedagogiki stosowanej do wspierania uczenia się muzyki poprzez audiację niemowląt, dzieci w wieku przedszkolnym i wczesnoszkolnym. Celem jest podkreślenie związków między muzyczną zabawą, kreatywnością, regulacją emocji i funkcjonowaniem wykonawczym. Przez dziewięć lat obserwowano 300 dzieci uczestniczących w zajęciach dla niemowląt i małych dzieci. Koncentrowano się na potencjale edukacyjnym wspólnych działań, które każdy nauczyciel uczący muzyki powinien kompetentnie realizować. Artykuł rozpoczyna się od wyjaśnienia terminów „uczenie się”, „rozwój” oraz „zrównoważone wspólne audiowanie”. Dalej zamieszczono rozważania o kreatywności w procesie absorbowania, imitowania i asymilowania oraz o regulacji emocji i funkcjonowaniu wykonawczym w procesie rozwoju audiacji. Postęp w uczeniu się muzyki we wczesnych latach życia jest identyfikowany w różnych sytuacjach edukacyjnych, gdzie obserwowane zachowania dowodzą o trajektorii rozwojowej małych dzieci uczących się muzyki. Ekspresja zaangażowania w śpiewanki i rytmiczanki wspiera teorie sugerujące powiązanie zabawy, kreatywności i regulacji emocji.