bluuebunny/crossref_metadata_2025 huggingface dataset:
Opportunities for early detection of prostate cancer in young and middle-aged men
Authors: Startsev V. Yu. , Shpot E. V. , Karaev D. K. , Krivonosov D. I.
Published: April 2022

Prostate cancer (PCa) is a public health problem worldwide. Among all malignant tumors, PCa ranks second in prevalence (105 out of 185 countries) and fifth in cause of death in men in 46 countries. In some cases, this pathology is verified in men under the age of 50, including the advanced stage of the metastatic process. The review article provides information on the epidemiology and prevalence of PCa in young men obtained from the PubMed, CrossRef, and Scopus databases. The data on the probable causal relationship of a number of factors potentially affecting the development of prostate carcinoma are presented. Little-known and new molecular genetic changes are described, including those associated with prostate-specific antigen (PSA), with a proven role in the development of this disease, the use of which will make it possible to predict PCa development in the early stages in a timely manner. It has been determined that the common methods for diagnosing carcinoma in the population, assessing the level of serum PSA, are not always accurate and that the algorithm for their use has not been finally formed. The study of risk factors for the development of PCa in young patients will make it possible to formulate a new diagnostic approach based on considering personal molecular genetic information. The development of this direction is relevant and has an important social and economic importance, considering the study of the contingent of the able-bodied population.
Platelet-rich plasma: application for interstitial cystitis and erectile dysfunction
Authors: Khamedov R. G. , Gorgotsky I. A. , Shkarupa A. G. , Shkarupa D. D. , Gadzhiev N. K.
Published: April 2022

Up-to-date, the platelet-rich plasma (PRP) treatment method is actively used in many fields of medicine. In traumatology, PRP is used to treat bone and cartilage defects, ligamentous apparatus. In combustiology for the healing of burns, in surgery ¾ trophic ulcers. There is evidence of the feasibility of using PRP in some dermatological diseases, as well as in dental practice. For urology, the method is new and is just beginning to be studied. The article discusses the methods of treatment of interstitial cystitis (IC) and erectile dysfunction (ED) using PRP. During the review, we relied on existing data on the effectiveness of intravesical injections of PRP in the treatment of IC, as well as on the successful treatment of ED with activated, nonactivated PRP and PRP augmented phosphodiesterasetype 5 (PDE-5) inhibitors.
The Effects of the COVID-19 Pandemic on Mental Health Among Older Adults From Different Communities in Chengmai County, China: Cross-sectional Study
Authors: Xu Zhimin , Ghisi Gabriela Lima de Melo , Cui Lixian , Zeng Fang , Zhou Xiaohai , Yue Zhongtang , Chen Hanbei
Published: April 2022

Background

Due to the strict measures employed to control the spread of SARS-CoV-2, the extent of COVID-19 goes beyond morbidity and mortality and affects individuals’ mental health in the long term.

Objective

This cross-sectional study aimed to investigate the effects of the COVID-19 pandemic on mental health and its contributing factors among older people in Chengmai County, China.

Methods

A web-based survey was administered through WeChat between March and April 2020. Older people (ie, >50 years) from local and foreign community groups completed the survey, which included items on sociodemographic and clinical characteristics, the 7-item Generalized Anxiety Disorder scale (GAD-7), and the 9-item Patient Health Questionnaire (PHQ-9). Independent t tests and a multiple linear regression analysis were used to investigate differences between anxiety and depression and the factors associated with these symptoms across the 2 groups.

Results

Overall, 469 responses were received; 119 responses (25.4%) were from male participants and 202 (43.1%) were from those older than 65 years. Of the 469 responses, 245 (52.2%) were from the local community group and 224 (47.8%) from the foreign group. The mean GAD-7 (P=.003) scores were significantly higher in the local group. Anxiety was significantly more present in the local group (61/245, 24.9% compared to 35/224, 15.6% in the foreign group; P=.01). A total of 6 respondents presented severe anxiety and 2 presented severe depression.

Conclusions

This study demonstrated that both community groups of older adults from the Chinese “Hometown of Longevity” presented anxiety or depressive disorders during the first months of the pandemic. Local community groups presented significantly more mental health disorders, which were associated with a history of previous psychological disorders.
ARTIFICIAL INTELLIGENCE IN PHARMACY DRUG DESIGN
Authors: V KALAYIL NISHA , D’SOUZA SHONA S , KHAN SHOWKHIYA Y , PAUL PALLAVI
Published: April 2022

Drug discovery is said to be a multi-dimensional issue in which different properties of drug candidates including efficacy, pharmacokinetics, and safety need to be improved with respect to giving the final drug product. Current advances in fields such as artificial intelligence (AI) systems that refine the design thesis through report investigation, microfluidics-assisted chemical synthesis, and biological testing are now giving a cornerstone for the establishment of greater automation into detail of this process. AI has stimulated computer-aided drug discovery. This could likely speed up time duration for compound discovery and enhancement and authorize more productive hunts of related chemicals. However, such optimization also increases substantial theories, technical, and organizational queries, as well as suspicion about the ongoing boost around them. Machine learning, in particular deep learning, in multiple scientific disciplines, and the development in computing hardware and software, among other factors, continue to power this development worldwide.
MALIGNANT OTITIS EXTERNA – OUR EXPERIENCE
Authors: MULLAPUDI HARINI , AV SARASWATHI
Published: April 2022

Objective: In this study, we aim to find out different symptoms and treatment outcomes of patients who are diagnosed with malignant otitis externa according to Levenson’s criteria, attending ENT OPD in a tertiary care hospital.
Methods: This is a prospective study, conducted over 18 months from August 2018 to February 2020 in the Department of ENT, GITAM Institute of Medical Sciences and Research, Visakhapatnam. Patients typically presented with nocturnal otalgia, persistent otorrhea, hearing loss, and aural fullness. Consent from patients for participation in the study has been taken. Complete history and thorough clinical examination were made, along with relevant investigations.
Results: Out of the 15 patients selected, MOE is more common in males (60%) than females (40%). The most common organism isolated is Pseudomonas aeruginosa. Nocturnal otalgia was the presenting complaint in all the patients. The age group commonly affected with MOE is 60−75 years. Facial nerve palsy is seen among 46% of the patients. Dry moping and application of betadine wick after the scrapping of granulations and reasonable glycemic control was helpful in-patient recovery in 50% of the cases.
Conclusion: Malignant otitis externa (MOE) is an aggressive infection representing a life-threatening condition. In our patients, a prolonged topical and oral antibiotic treatment and strict control of glycemic levels permitted to control the disease, but the surgical approach by debridement of granulations appeared essential for the resolution of the disease.
CLINICAL STUDY OF DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (DRESS) – WITH SPECIAL FOCUS ON THE INCITING DRUG AND THE INDICATION FOR STARTING THE DRUG
Authors: ZACHARIA MERIYA , P SEENA , SHAJ KIRAN , KESIEZIE NEIKHRIETSONUO
Published: April 2022

Objective: This study was undertaken to identify the most common drug causing drug reaction with eosinophilia and systemic symptoms (DRESS) inpatients admitted in our center and possible factors associated with it. Methods: This was a cross-sectional observational study of patients with DRESS admitted from January 2018 to December 2020. Data were entered in MS Excel and analyzed using SPSS software. Results: Eighty-four consecutive patients who were diagnosed as DRESS were included in the study. The most common inciting drug was phenytoin and the most common indication for starting phenytoin was traumatic brain injury (TBI) to prevent seizures. DRESS to phenytoin after neurotrauma (NT) was more in patients who sustained combined extradural (EDH) and subdural hematoma (SDH), and those were managed conservatively for NT. None of the patients recognized fever as an initial feature of DRESS and did not stop the drug. More than one-third of patients with erythema multiforme (EM) like rash developed drug induced liver injury(DILI). The majority of patients who had sub-arachnoid hemorrhage (SAH) developed DILI. Conclusion: Phenytoin though time-tested and cost-effective for prevention of seizures after TBI, it very commonly leads to DRESS which adds to the morbidity and rarely mortality of patient. In this present era of increasing road traffic accidents, using newer non-aromatic anticonvulsants may be more beneficial than phenytoin. The patients should be made aware of the likely time DRESS can occur, the earliest symptom of DRESS, and the need to stop the drug at the earliest.
ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES OF ETHANOLIC EXTRACT OF LEAVES OF PUNICA GRANATUM L. ON EXPERIMENTAL ANIMAL MODELS
Authors: KAUSHIK SHIPRA , MAHAJAN ABHISHEK , RAI JAYANT
Published: April 2022

Objective: The aim of the study is to evaluate the analgesic and anti-inflammatory activities of the ethanolic extract of Punica granatum L. (EEPG) on experimental animal models.
Methods: Tail-flick method was used to test the central analgesic activity, using Pethidine as standard drug. The tail flick latencies or the basal reaction time of the animals were assessed using an analgesiometer. Glacial acetic acid induced writhing response was used to test the peripheral analgesic activity, using Aspirin as standard drug. Number of writhing responses was counted for 20 min in each group and the percentage protection was calculated. And Carrageenan induced rat paw edema method was used to test anti-inflammatory activity of EEPG against acute inflammation, using Aspirin as standard drug. The inhibition of rat paw edema was calculated in percentage.
Results: In central analgesic activity, the extract and pethidine showed significant increase in the reaction time. In peripheral analgesic activity, the extract and aspirin significantly reduced the number of writhes induced by acetic acid. And in anti-inflammatory activity, the extract produced significant reduction of the carrageenan induced paw edema.
Conclusion: The EEPG has demonstrated significant analgesic and anti-inflammatory activity.
THE TRANSLATIONAL POSSIBILITY OF TARGETING LncRNAs AS A THERAPEUTIC STRATEGY FOR IDIOPATHIC PULMONARY FIBROSIS
Authors: YADAV RAKESH KUMAR , SHAH SHYAM , SHRIVASTAVA AMIT KUMAR , GAO JIAN
Published: April 2022

Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease (ILD). IPF causes stiffness in the lungs which makes it difficult to breathe and get oxygen to the bloodstream. IPF is a particularly severe form of lung fibrosis with no completely known etiology and a median survival of 2.5−3.5 years after diagnosis. The phenotypic changes in the lung fibroblasts are believed to contribute to the development of idiopathic pulmonary fibrosis. Long intergenic non-coding RNAs (LncRNAs) have been identified as novel regulators of gene expression and protein activity. In non-stimulated cells, it showed reduced proliferation and inflammation but no difference in the fibrotic response of IPF fibroblasts. These functional changes in non-stimulated cells were associated with changes in the expression of the histone marks, H3K4me1, H3K4me3, and H3K27ac indicating a possible involvement of epigenetics. Following activation with TGF-β1 and IL-1β, it demonstrated an increased fibrotic but reduced inflammatory response in IPF fibroblasts. No significant difference in proliferation following PDGF exposure was observed. The LncRNAs, LINC00960, and LINC01140 were upregulated in IPF fibroblasts. Knockdown studies showed that LINC00960 and LINC01140 were positive regulators of proliferation in both control and IPF fibroblasts but had no effect on the fibrotic response. Knockdown of LINC01140 but not LINC00960 increased the inflammatory response, which was greater in IPF compared to control fibroblasts. Overall, this review study tries to emphasize the role of LncRNAs as regulators of proliferation and inflammation in human lung fibroblast, a biomarker in IPF, and a novel treatment approach.
PROSPECTIVE STUDY COMPARING CONCURRENT CHEMORADIATION WITH OR WITHOUT GEFITINIB IN TREATMENT OF LOCALLY ADVANCED HEAD AND NECK CARCINOMA
Authors: BANERJEE BISWARUP , DE SUMITAVA , BISWAS LINKON , MANDAL SRIKRISHNA
Published: April 2022

ABSTRACT

BACKGROUND-Concurrent chemoradiotherapy (CTRT) is now an acceptable definitive therapy for locally advanced head and neck carcinomas. But, multiple studies revealed that addition of anti-EGFR agent with CTRT  improves the loco-regional response at a cost of higher but acceptable toxicity. Our study aimed at assessing CTRT with or without Gefitinib in terms of treatment response and acute toxicity profile.

MATERIALS AND METHODS- Patients with Locally advanced, non-metastatic, squamous cell carcinoma of Head-neck were  randomised in two groups-the control group  received  external beam radiotherapy  66Gy/33 fractions/6.5 weeks along with concurrent  injection Cisplatin at the dose of 100mg/m2 on day 1, 22, and 43 during radiation and the study group received concurrent chemoradiotherapy  along with  Tab Gefitinib-250 mg during the  duration of radiotherapy. Response assessment was done  after completion of treatment and all patients were followed up for treatment related acute toxicity during the course of treatment and then at every month for at least 6 months.

 RESULTS- 46.66% of study arm (CTRT+Gefitinib) patients showed complete response and  Overall response was 79%. In control arm (CTRT alone), there was 51.6% complete response  and Overall response was 77%, though difference was statistically not significant (p value 0.84). Although statistically not significant, Gefitinib containing arm had numerically higher hematological, gastro-intestinal toxicity and weight loss.

CONCLUSION- Gefitinib along with chemoradiation showed numerically higher overall response (complete response + partial response) and comparable acute toxicity profile in comparison to chemoradiation alone.
A RANDOMIZED CONTROLL TRIAL TO COMPARE THE EFFICACY OF SACCHAROMYCES BOULARDII, BACILLUS CLAUSII, AND LACTOBACILLUS RHAMNOSUS GG PREPARATION IN THE TREATMENT OF ACUTE DIARRHEA IN CHILDREN
Authors: SHARMA ABHISHEK KUMAR , PURI NEERAJ , MATHUR MADHU , MATHUR AMIT
Published: April 2022

Objective: Probiotics have been recommended as an adjunct to standard treatment of acute diarrhea but the choice of probiotics is unclear. The aim of study is to compare the efficacy of Saccharomyces boulardii, Bacillus clausii versus Lactobacillus rhamnosus in children with acute diarrhea and to expand the tolerability of S. boulardii, B. clausii versus L. rhamnosus GG in acute diarrhea.
Methods: Hospital based Randomized Controlled Clinical trial (chit in box) carried out at the Department of Pediatrics, Mahatma Gandhi Hospital, Jaipur Rajasthan from January 2020 to June 2021. 120 Children were enrolled in the study and randomized to either Group A or Group B or Group C. Group A received S. boulardii, Group B received B. clausii and Group C received L. rhamnosus GG. Sample size was 40 samples for each group. Statistical analysis was done with the SPSS software.
Results: There was statistically significant improvement in consistency observed in Group C as compared to Group A an Group B (p<0.001). Significant higher cases (87.5%) were improved in Group C compare to Group B (67.5%), followed by Group A (65%). While all patients were observed well tolerated and accepted during the study.
Conclusions: In our study, L. rhamnosus GG significantly reduce the frequency, improve the consistency of stools in diarrhea as compared to B. clausii and S. boulardii while tolerability of S. boulardii, B. clausii and L. rhamnosus GG was good with no adverse effect.
A PROSPECTIVE STUDY ON HYPONATREMIA IN CHILDREN WITH THE LOWER RESPIRATORY TRACT INFECTIONS ADMITTED IN PICU
Authors: SARISHMA CHAPARALA , GESHMANJALI KAKARALA , SAIKUMAR BONELA , KORIPADU SESHAGIRI
Published: April 2022

Objective: The present study has been undertaken to study hyponatremia in children with lower respiratory tract infections. The other objectives of the study were to evaluate the clinical and laboratory characteristics of children with hyponatremia and explore the relationship between hyponatremia and outcome about the duration of hospital stay and recovery/death.
Methods: The study included children aged 2 months to 5 years who were referred to the PICU, GITAM Institute of Medical Sciences and Research, Visakhapatnam from October 2018 to September 2019 with the lower respiratory tract infections were included in the study. A thorough clinical examination and detailed history have been completed and recorded into a prestructured pro forma. Hematological investigations have been done in all cases. Chest X-ray has been done in all cases to delineate the radiological features of LRTI. A venous blood sample was collected and sent to the biochemistry lab to evaluate serum sodium and was estimated by the ion-selective electrode method analyzed by the radiometer.
Results: 872 children were admitted to the pediatric intensive care unit during the study period. Among them, 100 children in the age group of 2 months to 5 years suffering from the lower respiratory tract infection were included in the study. Out of 100 cases of the lower respiratory tract infections, 59 cases were Pneumonia, and 41 cases were severe Pneumonia. Out of 100 cases, 68 cases accounting for 68% have normal sodium levels, 32 cases accounting to 32% had hyponatremia, and none had hypernatremia. Thus, third of the cases suffering from the lower respiratory tract infections had hyponatremia. The mean CRP in children with hyponatremia was 7.38 mg/dl, higher than children with normal sodium levels, that is, 2.30 mg/dl; this was also statistically significant (p<0.001). All 32 cases of hyponatremia and 68 cases of normonatremia recovered and were discharged. There was no mortality.
Conclusion: Children with hyponatremia had a longer duration of hospital stay. Serum sodium levels are an important biomarker and should be measured in all children hospitalized for the lower respiratory tract infections.
BIOCHEMICAL PROFILE, BACTERIAL PROFILE, AND ANTIBIOTIC SUSCEPTIBILITY PATTERN OF THE ISOLATES OF NEONATAL SEPTICEMIA IN TERTIARY CARE HOSPITAL, VISAKHAPATNAM
Authors: GESHMANJALI KAKARALA , SARISHMA CHAPARALA , SAIKUMAR BONELA , SUNEETHA NANNAPANENI
Published: April 2022

Objectives: The objective of the study was to determine sensitivity, specificity, and predictive values of C-reactive protein (CRP), leukocyte count, platelet count, and blood culture as indicators of neonatal sepsis.
Methods: This prospective study was conducted in the Department of Paediatrics, GITAM Institute of Medical sciences and Research, Visakhapatnam during January 2019 to December 2019. The institutional ethics committee had approved the study. Eighty clinically suspected cases of neonatal sepsis constituted material of study. All neonates who were clinically suspected sepsis, categorized into 0–72 h (early onset) or late onset (>3 days) sepsis based on day of presentation. Detailed history and clinical findings were recorded in the pro forma and screened with CRP and various hematological tests with predetermined cutoff values and at the same time blood culture was sent. Concerning a clinical scenario CSF, urine analysis, chest X-ray, and infective focus swabs were all taken. The length of treatment and time spent in the hospital were recorded. The death rate was calculated, and numerous risk variables were evaluated.
Results: Intrapartum risk factors such as a prolonged rupture of membrane >24 h, a long labor, several filthy vaginal examinations (>3) before birth, and foul-smelling liquid were all linked to culture-proven newborn sepsis. Any of the two risk factors listed above was a good predictor of sepsis with a positive culture. Neonatal sepsis impacted a higher percentage of low birth weight and preterm babies. The sensitivity and negative predictive value of the I/T ratio and CRP were both high. The most prevalent isolates were Klebsiella species, followed by Staphylococcus aureus and Escherichia coli. While S. aureus was 80% sensitive to Cefotaxime and Amikacin, Klebsiella species and E. coli were only 20% sensitive. All were sensitive to Ofloxacin in range of 75-100%. Septicemia with multiorgan dysfunction was the most common mode of death with 100% risk of mortality.
Conclusion: Intraparum risk factors are significantly with culture proven sepsis. All sepsis screening parameters used were statistically significantly associated with culture proven sepsis. I/T ratio and CRP were more sensitivity and had high negative predictive value. CRP can be used as an early and predictable screening test for diagnosing neonatal sepsis.
LITERATURE REVIEW: ANTIDIABETIC ACTIVITY OF HONEY
Authors: MAHANI  , NURFAUZIYAH SHASKI GHINA , WULANDARI ENDAH
Published: April 2022

Objective: The aim of this study is to determine the antidiabetic activity of honey for people with Type 2 diabetes mellitus (T2DM) by looking at its effect on glycemic response, glycemic control, and its synergistic combination with antidiabetic drugs.
Methods: The literature review starts from problem identification, data collecting, sorting the obtained data, reading, and analyzing, finally, compiling it into a systematic review.
Results: The results show that honey has antidiabetic potential for people with T2DM as indicated by resulting good glycemic response and its combination with antidiabetic drugs results in positive glycemic control.
Conclusion: Honey possesses antidiabetic activity that could make it as an ideal supplementation for people with T2DM by helping them to achieve the ideal glycemic control and avoid further diabetic complications.
COMPARATIVE STUDY OF FUNCTIONAL OUTCOME COMPARING POSTERIOR CRUCIATE LIGAMENT SUBSTITUTING PRIMARY KNEE ARTHROPLASTY WITH PRIMARY KNEE ARTHROPLASTY USING ULTRACONGRUENT TIBIAL ARTICULAR INSERT AFTER COMPLETE RELEASE OF POSTERIOR CRUCIATE LIGAMENT
Authors: GAJBHIYE DEWENDRA J , MITTAL GAURAV , ROUT ASHOK , SINGH SANTOSH KUMAR , KEDAR PRADEEP
Published: April 2022

Objectives: The aim of the study was to compare the functional outcome of posterior cruciate ligament (PCL) substituting primary knee arthroplasty with primary knee arthroplasty using ultra-congruent (UC) tibial articular insert after complete release of PCL. The study aimed to compare the stability of the knee joint after PCL sacrifice for degenerative arthritis of the knee.
Methods: This was a prospective, randomized, double blind, and single-center study. After approval by the Institutional Ethical Committee, 80 patients, 40 in each group (UC and posterior stabilized [PS]) of either sex, aged between 60 and 80 years and willing to participate in the study were included in the study. Patients underwent primary knee arthroplasty with either UC or PS implants using simple random sampling method. Each patient was followed up at 6 months, 1 year and between 5 and 7 years postoperatively and the functional results were assessed using Modified Knee Society Score (Insall modification -1993).
Results: Around 73% of the patients were women and the average age was 67 years in line with the known literature confirming increased incidence of osteoarthritis requiring total knee arthroplasty in women and older individuals. There was a significant relief in pain and improvement in stair climbing ability after surgery. There was a reduction in flexion contractures, medial/lateral instability, and anterior posterior instability postoperatively. The improvement in range of motion was significantly in the UC group as compared to PS group. Similarly, the total score was significantly higher in the UC group as compared to PS.
Conclusion: If functional outcomes are taken into consideration, UC prosthesis is better than the PS prosthesis. Further randomized and double-blinded clinical trials with larger sample size and longer duration follow-up need to be conducted to validate the findings.
Estimación de la recarga natural en la Cuenca de México mediante la aplicación del método APLIS
Authors: Palma Nava Adriana , Pavón Ibarra Ivonne , Domínguez Mora Ramón , Carmona Paredes Rafael Bernardo
Published: April 2022

El método APLIS es una herramienta que permite estimar la tasa media de recarga anual en acuíferos carbonatados, procedente de la infiltración de las precipitaciones en los acuíferos. La tasa es expresada como porcentaje de la precipitación, a partir de las siguientes variables: Altitud (A), Pendiente (P), Litología (L), áreas de absorción-Infiltración preferencial (I) y Suelo (S). Para cada variable se han asignado categorías o intervalos, estableciendo un valor entre 1 (mínima influencia en la recarga) y 10 (máxima influencia) y se han almacenado en un Sistema de Información Geográfica (SIG). Esto permite la superposición en el SIG de las capas de información correspondientes a las variables para calcular la tasa de recarga mediante la ecuación R = (A + P + 3·L + 2·I + S) / 0.9 y obtener la distribución espacial de la misma.
Driver Health Monitoring System
Authors: Balakrishnan Vidhya , J Sibhia , Mohanraj Dr. G.
Published: April 2022

Abstract: All over the world, most of the road accidents are occurred by driving and some rash driving due to health issues. The main concept of this paper is to prevent the road accident so to prevent the road accident we are using smart glasses and some IOT based small user-friendly devices. The eye blink sensors present in smart glass are used to check the driver is sleepy or not with the help of the eyeball movement of the driver, if the driver is sleepy means it will trigger the alarm to conscious the driver. The IOT health monitoring system keeps a check on the blood pressure, glucose and pulse rate of the driver and in case of any problem found it will send a message alert to the respective hospital. In this process, the message or SMS will send to the relative or doctor and the message will also send to the local police to prevent the accident. The alcohol detector is also used which is attached to the steering of the vehicle and it is notified to the respective place. Keywords: Safe Driving, IOT Sensors, Smart glasses, accidents
Research and Analysis of the Front-end Frameworks and Libraries in Web Development
Authors: Awasthi Arnav , More Shubham , Viegas Warren
Published: April 2022

Abstract: With the rapid expansion of online technology in recent years, there is a strong trend that Hypertext Markup Language (HTML)5 will become a global web consortium and will lead the front-end. to take stage in the history of the internet There are, however, a slew of front-end development frameworks to choose from., Angular, and are examples of libraries. How to Choose appropriate framework or library to launch an e-business and expand its react. It becomes a priority procedure to the user experience.in terms of web development This paper begins with an introduction a list of the most popular frameworks and libraries in the field of front-end development and web performance analysis services. This paper examines the research findings from a variety of perspectives. The advantages and disadvantages of each framework will be described in this study., the study concludes with a summary, the contributions, and finishes by speculating on the future of front-end development Keywords: Front-end; JavaScript; Web Development; e-Business; HTML5.
Study of Physiological Parameters and Rheology for the Production and Extraction of Cyclosporin A
Authors: Babu Prabhakar , Patel Yogesh , Pany Subhashis , Majeed Ilma , Luthra Dr. Umesh
Published: April 2022

Abstract: This study is an evaluative effort to analyse different physiological parameters and rheological properties observed during the fermentative production of cyclosporin A. Tolypocladium inflatum culture was used for seed development. For production fermentation, the mature seed was inoculated at specific transfer parameters. At each stage of the current study, pH, PMV and sugar consumption were keenly analysed and recorded. Different aeration rates and agitation speeds were evaluated during various stages of growth. Based on several experiments, the most optimised parameters were included for further analysis. The maximum productivity obtained was 8.3 g/L. Further, different kinds of solvents were studied to extract crude from the fermentation broth. Solvents required at various stages of downstream processing were analysed for best recovery with minimal product loss. Finally, the product was obtained with 80.58% recovery. Keywords: cyclosporin A, Tolypocladium inflatum, fermentation, seed, pH, PMV, extraction, downstream processing
Guerra do Paraguai: uma barbárie pela civilização
Authors: Junior Arnaldo Lucas Pires
Published: April 2022

Este artigo objetiva discutir as relações existentes entre os processos de construção das identidades nacionais brasileira e paraguaia e a Guerra do Paraguai (1864-1870). Buscamos explorar as formas com as quais a dicotomia “civilização vs barbárie” se integrou, nesse contexto, e como adquiriu uma posição de protagonismo nas diferentes visões sobre a guerra. Dessa forma, propomos um breve mergulho nesses jogos de construção identitária, a partir da leitura dos periódicos ilustrados brasileiros e paraguaios publicados durante o conflito. A análise de seus artigos e, principalmente, das charges publicadas nesses periódicos nos proporcionou um olhar agudizado e nos auxiliou a trazer à luz um dos grandes paradoxos do conflito, a saber, fazia-se uma guerra, cuja crueza a aproximava de todas as noções de barbárie, sob a justificativa da civilização.
O mundo atlântico português: dinâmicas coloniais, econômicas, políticas e sociais
Authors: Sampaio Thiago
Published: April 2022

RUSSELL-WOOD, A. J. R. Histórias do Atlântico Português. São Paulo: Editora UNESP, 2014, 404 p.Quando se pensa no Oceano Atlântico lembra-se dos continentes banhado por este (europeu, africano e americano) e suas distâncias, mas se esquece que ele interligou culturas e sociedades distintas mais do que as separou. É a partir destas indagações que foi produzida a obra Histórias do Atlântico Português, uma coletânea de artigos produzidos ao longo da vida pelo brasilianista Anthony John Russell-Wood, organizado por Denise Moura (UNESP/Franca) e Ângela Domingues (Instituto de Investigação Científica Tropical, Lisboa).
Entrevista com Eugenio Raúl Zaffaroni
Authors: Alves Tamires Maria , Gusis Gabriela Laura
Published: April 2022

Eugenio Raúl Zaffaroni é um reconhecido jurista latino-americano, com numerosas obras sobre Direito Penal e Criminologia publicadas na Argentina, Brasil, México, Colômbia e outros países do continente. Entre seus livros, destacamse o Tratado de Direito Penal, Manual de Direito Penal, Direito Penal Nazi, A Palavra dos Mortos – conferências de Criminologia Cautelar, Em busca das Penas Perdidas, O inimigo no Direito Penal, entre outras. Com uma trajetória de mais de trinta anos no Poder Judiciário, foi juiz em distintas instâncias, Procurador Geral da Província de San Luís, culminando sua vida judicial argentina como Ministro da Corte Suprema de Justiça da Nação, cujo cargo manteve até sua renúncia, no ano de 2015. A partir deste, tornou-se juiz membro da Corte Interamericana de Direitos Humanos, órgão jurisdicional máximo da OEA. É doutor pela Universidade Nacional do Litoral, professor Emérito da Universidade de Buenos Aires, Professor honoris causa por universidades americanas e europeias, professor convidado nas mais prestigiosas universidades, em nível mundial. Foi reconhecido com o prêmio máximo em Criminologia, no ano de 2009, o Prêmio de Estocolmo, por sua pesquisa sobre Crimes em massa. Foi pesquisador da Universidade de Buenos Aires e do Instituto Max Planck, interventor do Instituto Nacional contra a Discriminação e a Xenofobia da Nação, legislador e Constituinte Convencional na Última Reforma da Carta Magna argentina. No dia 26 de março de 2018, as entrevistadoras Tamires Alves e Gabriela Gusis tiveram o prazer de encontrá-lo, na Universidade de Buenos Aires, para uma conversa sobre a justiça penal contemporânea. Nessa oportunidade, debateram temas referentes principalmente ao contexto latino-americano, tendo em vista a circunstância, já destacada, que o professor exerce o cargo de juiz da Corte Interamericana de Direitos Humanos. Nessa entrevista, Eugenio Raúl Zaffaroni aborda matérias basilares para os anseios políticos contemporâneos, como a criminalização da pobreza, a seletividade penal e o hiperencarceramento brasileiro.
O modelo de secularismo português: análise dos padrões democráticos de relação Estado-religião(ões) no Portugal pós-25 de Abril
Authors: Moniz Jorge Carlos Serrano Botelho
Published: April 2022

Este artigo visa a observar as distintas dimensões e os vários contornos do secularismo hodierno. Através de uma análise descritiva, que tem como marco teórico os múltiplos secularismos e as análises sensíveis ao contexto, examinam-se as relações entre o Estado português e as igrejas e comunidades religiosas, no período pós-1974. Ao analisarmos o seu padrão democrático de relação Estado-religião, nomeadamente através do exame dos mecanismos de apoio financeiro estabelecidos, procuramos entender em qual dos atuais modelos de secularismo Portugal se enquadra. O fato de este ser um caso de estudo complexo, onde persiste um padrão de separação com cooperação entre Estado e religião e, por consequência, um espírito de diálogo, negociação e de permanentes (re)definições do espaço público e simbólico de ambos, com particular relevo para uma organização religiosa, permite compreender o quão ambíguas e plásticas podem ser as fronteiras do secularismo moderno.
Direcionamento da agenda no processo de construção da “Aliança Democrátcia frente Liberal-PMDB” para as eleições Indiretas de 1985
Authors: Venturini Fabio
Published: April 2022

Este trabalho trata sobre a construção discursiva e ideológica da campanha da chapa “Aliança Democrática PMDB-Frente Liberal”, a qual elegeu Tancredo Neves à presidência da república via colégio eleitoral, com José Sarney como vice, no ano de 1985. Faz uma análise histórica da formação dos partidos que disputaram qual alternativa seria a vencedora da disputa política na primeira metade dos anos 1980, com a conquista da direção do processo de constitucionalização nacional pós-ditadura militar. Numa comparação de tendências de votos dos dois eventos conexos no Congresso (PEC 5/1983, de eleições presidenciais diretas, e o colégio eleitoral de janeiro de 1985), bem como análise de discursos políticos e materiais da campanha presidencial da Aliança Democrática, verificou-se que a campanha política junto à população, com vistas a eventos de deliberação restrita ao colégio eleitoral, as ações da Aliança Democrática tinham como objetivo construir legitimidade em torno de uma agenda conciliada por cima, elaborada e proposta inclusive por membros da base de apoio da ditadura. Conclui-se que a campanha teve como finalidade desviar o debate das pautas propostas pelos movimentos sociais, sindicais e populares que pressionaram a redemocratização por baixo durante as mobilizações por eleições presidenciais diretas, os quais propunham reforma agrária, ampliação de direitos trabalhistas e humanos, revisão de dívida externa, restabelecimento de relações com países socialistas etc., com a construção de uma agenda baseada em temas típicos da propaganda da própria ditadura que legitimava mudanças feitas pelo alto: a união nacional, o patriotismo e o civismo.
Alternância como princípio e forma de organização do trabalho pedagógico no Curso de Licenciatura em Educação do Campo
Authors: Melo Keylla Rejane Almeida , Melo Raimunda Alves , França-Carvalho Antônia Dalva
Published: April 2022

Este texto analisa desafios e perspectivas da Pedagogia da Alternância desenvolvida no Curso de Licenciatura em Educação do Campo (LEdoC), da Universidade Federal do Piauí, e sugere ações que materializem as proposições do Projeto Pedagógico do Curso (PPC). O artigo é um esforço teórico de análise da experiência desenvolvida, fundamentado nos referenciais da Educação do Campo. Os resultados do estudo apontam para uma dicotomia, na LEdoC, entre os dois tempos formativos que constituem a Pedagogia da Alternância: Tempo Universidade e Tempo Comunidade, apesar de haver possibilidades efetivas de inserção dos estudantes na sua realidade social, no entanto, esta inserção está ligada exclusivamente às atividades do Tempo Comunidade, sem uma integração deste com os estudos realizados no Tempo Universidade. Conclui-se que é necessária a reestruturação da proposta de Alternância do Curso, numa perspectiva integrativa, de forma a viabilizar práticas educativas que fortaleçam os princípios, conceitos e metodologias da Educação do Campo.
alfabetização na revista O Ensino-PR (1922-1924)
Authors: Zanlorenzi Claudia Maria Petchak , Nascimento Maria Isabel Moura
Published: April 2022

A imprensa periódica educacional, no início do século XX, foi um recurso comumente utilizado, haja vista a precariedade da formação docente no Brasil. No Paraná, destaca-se a revista O Ensino, publicada entre os anos de 1922 a 1924, pela Inspetoria Geral do Ensino do Paraná. O presente estudo tem por objetivo analisar a referida revista, especificamente, investigando as temáticas sobre alfabetização. Verifica-se  que a alfabetização, de forma pragmática, foi a pauta que frequentemente era registrada na revista em consonância com os demais debates, constituindo-se como solução para os problemas da educação. Outrossim, o estudo incita questões e debates, principalmente sobre a alfabetização e o quanto o tema é frequentemente abordado nas propostas de reformas governamentais desde o início do século XX e como a ênfase no fazer docente, sem uma formação teórica consistente, continua sendo a estratégia utilizada oficialmente.
experiência como professor(a) regente nos estágios curriculares obrigatórios
Authors: Lima Tatiana Polliana Pinto de , Santos Thaís Aline da Silva dos
Published: April 2022

A pesquisa busca compreender o significado atribuído à recepção de estagiários e à função de professor regente pelos docentes de Ciências e Biologia dos Anos Finais do Ensino Fundamental e do Ensino Médio, no tocante à contribuição dessa atividade às suas práticas docentes. O estágio supervisionado, se realizado com comprometimento pelos agentes participantes, pode constituir-se um processo proveitoso tanto para a formação inicial do futuro professor, quanto para as práticas dos professores regentes. Para o desenvolvimento da pesquisa, a partir de uma abordagem qualitativa, foram realizadas entrevistas com um professor e duas professoras que relataram suas experiências como regentes responsáveis pelo acompanhamento dos estágios nas Escolas de Educação Básica de Cruz das Almas-BA. Ao final, percebe-se que os professores regentes identificam aspectos a serem melhorados no contexto do estágio supervisionado, mas reconhecem que o estágio tem proporcionado proveitosas trocas de experiências que os ajudam na revitalização de suas práticas docentes.
Educação Ambiental e professores de Geografia
Authors: Cid Eduardo Fausto Kuster
Published: April 2022

Este artigo é fruto de um estudo realizado em 2018, com o objetivo de evidenciar práticas pedagógicas e abordagens voltadas para a temática ambiental de professores dos cursos de licenciatura em Geografia. Como recurso metodológico na busca pela trajetória desses docentes o método escolhido foi a entrevista narrativa, por se mostrar um recurso da pesquisa qualitativa que permite combinar histórias de vida, motivações e compreender as ações desses docentes em sala de aula. Para sua realização foram entrevistados 35 professores lotados em diferentes instituições (ensino fundamental, médio e superior), oriundos das cinco regiões brasileiras. Os resultados da pesquisa buscam traçar, pela lente desses professores, um breve panorama do ensino da Educação Ambiental (EA) nos cursos de Geografia e contribuir para reflexão sobre novas práticas e processos de ensino e aprendizagem.
Convivência, ética, e autoridade na educação infantil
Authors: Hoppe Martha Marlene Wankler , Santos Tatiane Lopes do
Published: April 2022

Investigamos neste estudo os aspectos éticos da convivência na escola de Educação Infantil e o uso da autoridade pelo professor. Indagamos sobre as situações éticas enfrentadas pelos professores na prática docente para compreender como conduzem a relação com alunos e famílias. Dez professores participaram deste estudo. Foi utilizada uma metodologia qualitativa com entrevistas individuais gravadas e transcritas. Os relatos foram analisados de modo descritivo com identificação e caracterização das diferentes situações éticas enfrentadas e das reflexões sobre cada uma delas. Constatamos que os professores usavam sua autoridade enquanto poder, ou seja, desvinculada das decisões com as famílias e as crianças. Esta forma de autoridade não considera o modo de relacionamento da criança nas famílias e não favorece a aproximação e o respeito. As relações sociais na escola permitem ao professor construir uma ética de convivência, por meio da qual irá formar sua autoridade e participar das transformações na sociedade.
protagonismo da Comissão Brasileiro-Americana de Educação Industrial (1946-1962)
Authors: Bordignon Talita Francieli
Published: April 2022

Sob o ponto de vista do materialismo histórico e dialético, o presente artigo busca analisar o protagonismo da Comissão Brasileiro-Americana de Educação Industrial (CBAI) entre 1946 e 1962, em suas ações de promoção da hegemonia burguesa. Tomando como fonte histórica o Boletim da CBAI, observa-se a ampliação do Estado na interpenetração entre público e privado. A burguesia brasileira movimentou seus intelectuais orgânicos e os empenhou na solidificação do liberalismo, de modo que a inculcação do American way of life fosse guiada pelo americanismo e o fordismo, como na análise de Gramsci. O escolanovismo na educação técnica industrial foi a estratégia que os donos do poder usaram para operar a manutenção da ordem liberal burguesa. O princípio da unificação diferenciadora foi divulgado nestas escolas para entranhar estes pressupostos na mentalidade dos trabalhadores, a fim de manter a sociedade organizada em classes antagônicas.
Educação especial e inclusiva
Authors: Rodrigues Ellen Cristina Carvalho , Sá Pedro Franco de
Published: April 2022

A educação especial é um tema difundido universalmente, por isso, este artigo busca demonstrar a importância dessa discussão através de análises de pesquisadores da área, como Delors, Kassar, Rocha, entre outros. Além disso, busca mostrar seu processo evolutivo e embasar suas normativas pelas Leis e Decretos federais que constituem a forma em que a educação especial é realizada na rede regular de ensino. Por fim, porém não menos importante, também retratamos como é executada a educação especial no contexto matemático e as implicações que tais leis trazem, voltando o olhar aos eventos nacionais e a criação de um eixo especifico de educação especial e inclusiva nestes eventos. O texto está dividido em três momentos: no primeiro momento fala sobre a conquista da Educação Especial; em seguida, trata sobre a Educação Especial nas escolas; e finaliza com a inserção em eventos. Com isso, concluímos que a inserção de uma educação mais igualitária para todos ainda caminha a passos lentos, no entanto, há grandes progressos oriundos de discussões de pesquisadores, estudantes e tantos outros que pensam nessa educação.
John Locke e a educação
Authors: Pita Crislaine Aparecida , Gomes Marco Antônio de Oliveira , Rodrigues Ana Paula Aires
Published: April 2022

Este artigo se propõe, a partir de uma abordagem materialista-dialética, a analisar as condições históricas que possibilitaram o desenvolvimento dos pressupostos liberais no contexto da modernidade e discuti-los enquanto ideologia, que se tornou a hegemônica defensora da primazia dos direitos naturais do homem burguês moderno, considerando-se, principalmente, os enunciados teóricos de John Locke (1632-1704). A partir das análises realizadas, percebe-se que, em última instância, este legado teórico tem como cerne a defesa dos direitos naturais, essencialmente, da liberdade, da igualdade e, da propriedade. Busca-se, então problematizar as implicações desse pensamento para educação no bojo das transformações históricas, já que, ao homem burguês moderno caberia uma educação voltada para coordenar a nova sociedade capitalista que se forjava, qual seria então aquela destinada ao trabalhador livre assalariado, nascente juntamente com a burguesia em ascensão?
conhecimento e as virtudes como fundamentos para as ações do líder/governante
Authors: Torquatro Patrícia Caroline da Rocha Leprique , Oliveira Terezinha
Published: April 2022

O artigo tem por objetivo apresentar o reinado de D. Afonso IV (1291-1357) no governo de Portugal, no século XIV, com ênfase nas suas atuações em relação ao desenvolvimento e proteção da Universidade. Esse estudo pauta-se, principalmente, em Cartas do referido rei, contidas no Chartulariium Universitatis Portugalensis. Considerando a perspectiva da longa duração, independentemente do tempo histórico, o governante desempenha um papel social essencial. Tanto as cidades como as Universidades necessitam de um líder preparado, educado para praticar as virtudes, pensar e agir em direção ao bem comum, ao desenvolvimento da sociedade. Para isso verificaremos sobre as características desse conhecimento a partir das formulações de Boaventura de Bagnoregio (1217/21-1274) e Tomás de Aquino (1224/25-1274), ambos do século XIII. Também apresentaremos o reinado de D. Afonso IV e suas influências no governo de Portugal, no século XIV. O estudo pautou-se, principalmente, no escrito Do reino ou do governo dos príncipes ao rei de Chipre, de Tomás de Aquino; na obra As Seis asas do Seraphim, de Boaventura de Bagnoregio e em Cartas, do século XIV, de D. Afonso IV, contidas no Chartulariium Universitatis Portugalensis. Entende-se que esse estudo se constitui como uma possibilidade de reflexão sobre as possíveis ações do governante/líder seja na sociedade, seja na escola/universidade.
cinema em movimento
Authors: Wolf Alexandre Silva , Araújo Denize Correa
Published: April 2022

O cineasta norte-americano Woody Allen possui uma obra extensa originada nos anos sessenta, que tem sua continuidade até os dias de hoje. Sua obra está situada dentro das características do cinema contemporâneo, pois nela encontramos muitas das práticas do cinema pós-moderno. Em seus filmes, Allen apresenta relações, entendidas neste trabalho como diálogos, que acontecem em dois sentidos, internos e externos, que contribuem para o enriquecimento das possibilidades criativas. A partir da análise comparativa dos filmes Play it again, Sam (1972) (Sonhos de um sedutor (1972)), Casablanca (1942), dirigido por Michael Curtiz, Café Society (2016) e Radio Days (1987) (A Era do Rádio (1987)), buscamos compreender algumas das formas de diálogos propostas por ele.