bluuebunny/crossref_metadata_2025 huggingface dataset:
PENGARUH SEKTOR PARIWISATA TERHADAP PENYERAPAN TENAGA KERJA DI PROVINSI JAWA TIMUR TAHUN 2012-2018
Authors: Indah Fathya Rizki , Nuraini Ida , Syaifullah Yunan
Published: April 2022

This aims of this reseach to analyze the effect of  sector of tourism on absorption of labor in East Java Province in 2012-2018 (Study case: Regency/City in East Java Province). This research used secondary  and the data obtained from the Tourism Office of East Java Province, the Office of Manpower and Transmigration of East Java Province and the Central Statistics Agency of East Java Province. The analysis technique in this research is panel data analysis wich is prossed using Random Effect Model (REM) . The dependent variable in this study is labor in the tourism sector in the Regency/City East Java Province in 2012-2018, while independent variables is the number of hotels, the number of restaurants, the number of tourism objects and number of tourists in the Regency / City of East Java Province in 2012. -2018. In this reseach, it is found that the variables number of hotels, the number of restaurants, the number of Tourism objects a positive and significantly. However, for the variable number of tourists a positive but does not effect absorption of labor in the tourism sector in the Regency / City of East Java Province.
PENGARUH PENGETAHUAN PRODUK, BIAYA ADMINISTRASI DAN BAGI HASIL TERHADAP MINAT MASYARAKAT
Authors: Rosidi Ach
Published: April 2022

The purpose of this research is to examine and analyze the effect of product knowledge, administrative costs and profit sharing on public interest. The population is customers at the savings account of KCP Sampang with a sample of 100 respondents and using incidental sampling techniques, primary data collection using questionnaires and secondary data using literature and documentation studies. Hypothesis testing in this study using multiple linear regression. Simultaneously product knowledge, administrative costs and profit-sharing have a significant effect on people's interest in becoming customers in KCP Sampang's barokah savings. Partially, product knowledge has a positive effect on customer interest, administrative costs have the most dominant effect on public interest and profit sharing has an effect on customer interest.
STRATEGI PENGEMBANGAN INDUSTRI KERAJINAN TAS NOKEN (STUDI KASUS PENGRAJIN LOKAL KABUPATEN MIMIKA)
Authors: Zonggonau Arief S. , Rahayu Yuyun P. , Maspaitella Marcus R.
Published: April 2022

This study examines the strategy for developing the Noken Bag Handicraft Industry (Case Study of Local Communities in Mimika Regency) by using three indicators: capital, raw materials, and marketing. Business owners or Noken artisans at the research location are the samples of this study gathered by the census method. Data retrieval used primary data and secondary data. Primary data obtained through questionnaires, and secondary data obtained through agencies and institutions related to this research. In addition, the analytical methods and tools used are descriptive statistical analysis and SWOT analysis. The results of this study are the formulation of a strategy for developing the Noken bag craft industry includes two approaches, precisely a method based on internal-external matrix analysis and a combination of SWOT matrix strategies. First, based on the SWOT internal-external matrix, the results show that the Noken bag craft industry in cell V is said to be in a position of concentration strategy through horizontal integration. Secondly, based on the SWOT matrix, the priority strategy that the Noken bag craft industry should apply is the SO strategy, which is a strategy that uses strength to take advantage of opportunities seen through three indicators, specifically capital, raw materials, and marketing.
ANALISIS DAMPAK PANDEMI COVID-19 TERHADAP PENDAPATAN NELAYAN TRADISIONAL DI KELURAHAN PASIR PUTIH DISTRIK MANOKWARI TIMUR KABUPATEN MANOKWARI (STUDI KASUS NELAYAN DI WILAYAH PASIRIDO)
Authors: Rumfabe Hengky , Wurarah Rully N. , Parinusa Sisilia Maria
Published: April 2022

This study aims to determine the effect of demand, fish prices and production costs on the income of traditional fishermen in the Pasirido area, East Manokwari District before and after the COVID-19 pandemic and whether there is a difference in the income of traditional fishermen both before and after the pandemic. The type of this research is quantitative descriptive with the number of samples used in this study are 45 traditional fishermen. According to analysis result, it is known that both before and after pandemic COVID -19 consumption, selling price have a positive and significant effects to the fishermen’s income on the other hand cost production has a negative and significant effect. Furthermore, before the pandemic it was known that the average income of fishermen was IDR 2,392,422.22 and after the pandemic the average income of fishermen was IDR 2,174,866.67. In addition, the most dominant variable that affects the income level of fishermen both before and after the pandemic is the variable of consumption or community demand
ANALISIS FAKTOR – FAKTOR YANG MEMPENGARUHI PENERIMAAN PAJAK DAERAH DI KABUPATEN MANOKWARI TAHUN 2013 – 2017
Authors: Ririhena Stenly Andry , Maspaitella Marcus R. , Yap Rumas Alma
Published: April 2022

This study aims to determine the influence and the most dominant factors affecting tax revenue in Manokwari Regency in 2013-2017. This study uses quantitative methods. The type of data used is secondary data consisting of local tax revenues, number of visitors to tourism objects, hotel room occupancy rates and GDP at constant prices in Manokwari Regency. The data collection method uses the library method, while the analytical tool used is the multiple linear regression analysis method. The results showed that partially income per capita had a positive and significant effect on tax revenue in Manokwari Regency, the number of visitors to tourism objects had a negative and significant effect on tax revenue in Manokwari Regency and hotel room occupancy rates had a positive and significant effect on local tax revenue in Manokwari Regency. . The dominant factors on local tax revenue are income per capita and hotel room occupancy which have a positive and significant effect on local tax revenue in Manokwari Regency.
Antioxidant, Anti-Inflammatory and Wound Healing Activities of Cochlospermum planchonii Hook. F.
Authors: Fankibe Nakpane , Kantati Yendubé T. , Metowogo Kossi , Kombate Bignoate , Adi Kojdo , Itiblitse Kossitsè , Darré Tchin , Eklu-Gadegbeku Kwashie , Aklikokou Kodjo A.
Published: April 2022

Objective: The medicinal plant Cochlospermum planchonii Hook.f. is used in the management of various ailments in Togolese pharmacopoeia. In this study, we aimed to evaluate the antioxidant and anti-inflammatory activities of roots and leaves of C. planchonii, and burn wound healing activity of its leaf hydroethanolic extracts in rodents.

Materials and Methods: Antioxidant activities were assessed using Phosphomolybdenum assay, 2,2-diphenyl-1-picrylhydrazyl (DPPH) test and the reducing power assay. Visceral pain model, formaldehyde-induced paw edema and vascular permeability test were performed to evaluate anti-inflammatory activities in vivo. Burns were induced in rats by applying on the skin of the dorsal region an aluminum plaque preheated to 100°C for 10 seconds. Animals were treated topically with empty Carbopol gel, C. planchonii leaves extract 2.5 and 5 % in Carbopol gel, and Brulex® (Zinc oxide 15 % cream).

Results: C. planchonii extracts exhibited good antioxidant capacities close to standard compound, ascorbic acid. Leaves and root hydroethanolic extracts (1000 mg/kg), compared to control animals, significantly reduced the number of writhings (P<0.001) and the volume of paw edema (P<0.001). Similarly, both roots and leaf extracts at 1000 mg/kg have significantly inhibited vascular permeability by approximately 50% compared to the control group. C. planchonii leaves hydroethanolic extract 2.5 and 5 % in Carbopol enhanced wound healing via significantly increased contraction rates (78.63 ± 1.57 and 79.68 ± 1.48 respectively on day 12, P<0.001), confirmed by histological observations.

Conclusion: C. planchonii can promote burn healing due to anti-inflammatory, antioxidant and antimicrobial properties of the plant.

Keywords: Cochlospermum planchonii, inflammatory, antioxidant, edema, burn wound
Phytochemical, toxicity and antihyperglycaemic effects of Zea mays Linn leaves’ extracts
Authors: KOTIN Lucrèce Mahoutin , ASSOGBA Fidèle Mahoudo , AKAKPO Huguette Baï , AHOUNOU AIKPE Judith Fifamin , GODONOU Jean-Benoît , DANSOU Pierre Houndjovi , GBENOU Joachim Djimon
Published: April 2022

In the Republic of Benin, several plants, including Zea mays Linn (Z. mays) are used for the treatment of diabetes without any scientific studies showing their effectiveness. The objective of this study is to investigate the effects of Z. mays leaves’ extracts on hyperglycaemic rabbits using the Oral Glucose Tolerance Test (OGTT), 2 g/kg of (D) + glucose and on hepatic glucose liberation. Phytochemical screening revealed that the plant leaves contain alkaloids, tannins, mucilage flavonoids, anthocyanin, leuco-anthocyanin, coumarins, heteroside, flavonoid, triterpenoids, steroids, reducing compounds, saponins, oses and holosides.  Cytotoxity tests showed that the aqueous and ethanolic extracts were free of toxicity. The extracts have shown anti-hyperglycaemic activities dependent on specific dosage and timing. The effective dose is 500 mg/kg for the aqueous extract and for the ethanolic extract. The extracts are effective as compared with glibenclamide (reference product). Moreover, the ex vivo test conducted on the liver revealed that Z. mays aqueous extract inhibits the hepatic glucose liberation and 500 mg/kg is the most effective dose.

The results of this study justify the traditional usage of the plant leaves under consideration in the treatment of diabetes.

Key words: Zea mays extracts, phytochemical, hyperglycaemia, hepatic glucose, toxicity, Benin.
The Effect of Foot Exercise on Daily Activities and Blood Sugar Levels of Elderly in South Bangka, Indonesia
Authors: Nurhayati Nurhayati
Published: April 2022

Background: The elderly are a group of people who are at risk of developing diabetes mellitus. Foot exercise is appropriate for elderly people with diabetes to prevent injuries and help improve blood circulation in their feet and also could control blood sugar level. Objective: This study time to determine the effect of foot exercise on daily activities and blood sugar levels among elderly in Tanjung Ketapang Village, Toboali District, South Bangka Regency. Methods: The research employed a quasi-experimental one-group pretest-posttest design. Data were collected using two-part questionnaires: (1) contains the characteristics of the respondents, including age, gender, education, occupation, and (2) contains questions about Activities of Daily Lives and Blood Glucose Level. Data were analyzed using the Statistical Product and Service Solution program with the Independent t-test and then presented in univariate and bivariate analysis. Results: The study found the correlation between Activities of Daily Lives and Blood Glucose Level on foot exercise showed that the Blood Glucose Level before the exercise was 2.28, while after the exercise was 1.86. There is an effect of giving foot exercises to the elderly on Activities of Daily Lives and Blood Glucose Level with a significance p-value of 0.013 and 0.000, respectively. Conclusion: Foot exercise can be used as a standard of nursing care in both hospital and community settings to help and promote the program that has been established to reduce Diabetes Mellitus cases in Bangka Belitung Province.

Keywords: Activity of daily lives, blood glucose level, elderly, foot exercise
Educational comics: a change in the attitude of 3M children aged 10-12 years during the covid-19 pandemic
Authors: Pongoh Ariani
Published: April 2022

Background: Covid-19 is a disease caused by a new type of Coronavirus namely Sars-CoV-2 which is transmitted through close contact and droplets. Symptoms are acute respiratory disorders such as cough, shortness of breath and fever above 38℃. Attitude change is a stimulus or stimulus received by a person, either in the form of a positive or negative response. Educational comics are pictures and writings that make up a story, then packaged into a book. The comic "Kitorang Lawan Corona" is more interesting for the readers. Objective: This study was to analyze the effectiveness of educational comics on changes in 3M attitudes in children aged 10-12 years during the covid-19 pandemic. Methods: The research design used was a quasi-experimental approach with a one group pretest-posttest design. The subjects of this study were students of MI Al-Kautsar Sorong City aged 10-12 years. Measurement of attitude change was carried out before and after giving educational comics using a Likert questionnaire. Analysis of research data using the Wilcoxon test. Results: providing comics education was significantly (p=0.000) effective on changing 3M attitudes in children aged 10-12 years during the covid-19 pandemic. Conclusion: Educational comics are effective in changing 3M attitudes in children aged 10-12 years during the covid-19 pandemic.

Keywords: Attitude change, health protocols, educational comics.
Ficus religiosa: A beneficial medicinal plant
Authors: Kapile Chinmay , Kulkarni Abhijeet , Pardeshi Pooja , Sayed Adnanulhaque , Nehe Akshay
Published: April 2022

In India, herbs have been the primary means of treatment. The existence of secondary plant metabolites, which are combinations of chemical substances with different amalgams, in one or more sections of medicinal plants confers therapeutic qualities. Ficus religiosa, sometimes known as peepal, belongs to the Moraceae family of plants. The Bo tree, Ficus religiosa, provided shelter to the Buddha as he divined the "Truths." In Ficus religiosa, phenolic components, hydrocarbons, aliphatic alcohols, volatile components, phytosterols, amino acids, furanocoumarins, and a few more types of secondary metabolites have been isolated by phytochemical studies. Both (In vitro and in vivo) pharmacological activities of Ficus religiosa crude extracts and isolated components included anti-inflammatory, analgesic, antimicrobial, antiviral, hypolipidemic, antioxidant, immunomodulatory, antiasthmatic, parasympathetic modulator, estrogenic, anticancer, antiulcer, antianxiety, anthelmintic, endothelial receptor antagonistic, apoptosis inducer, and hypotensive activities.

Keywords: Ficus religiosa, phytoconstituents, pharmacology, toxicity
Innovation and optimization of Rizatriptan Benzoate Oromucosal Tablets by Using Design of Experiment (DoE)
Authors: Sonawane T. D. , Pawar S.P.
Published: April 2022

The present study deals with the formulation and study of oromucosal tablets of Rizatriptan Benzoate (RB) using different bioahdesive polymer. Nine formulations were prepared by using direct compression method. Hydroxypropyl methyl cellulose (HPMC K4M), Gum acacia and Sodium Alginate were used as buccal mucoadhesive polymer. Ethyl cellulose (EC) used as an impermeable backing layer. FTIR Studies showed no interaction with drug, polymer and excipients. 32 full factorial design was used to optimize the effect of independent variable such as concentration of HPMC K4M (X1) and concentration of Sodium Alginate (X2) on dependent variables such as % drug release (Y1), Mucoadhesive strength (Y2), Swelling Index (Y3). The prepared buccal mucoadhesive tablets were evaluated for weight variation, Hardness, Surface pH and drug content, content uniformity, swelling index, In-vitro drug release study and mucoadhesive strength. In-vitro drug release study showed sustained drug released for 9 hours. The In-vitro release kinetics reveals that formulation DE5 follows Higuchi model for drug release.

Keywords: Buccal Mucoadhesion, HPMC K4M, Sodium alginate, Design of experiments.
UM ESTUDO DE CASO DE ANOREXIA NERVOSA: desafios e possibilidades na terapia cognitivo-comportamental
Authors: Broering Camilla Volpato , Scherer Alessandra
Published: April 2022

The propagation of a thin body culture and an aesthetic standard to be followed by society has increased the incidence and prevalence of eating disorders. These disorders, related to body image distortion, have been growing exponentially in several countries around the world. They are increasingly characterized as an area of interest for health professionals, however, there are still few Brazilian studies on the treatment of these pathologies from the point of view of Cognitive-Behavioral Therapy. Eating disorders are conditions known for aspects such as the morbid fear of gaining weight, voluntary reduction in nutritional consumption, massive food intake followed by vomiting and abusive use of laxatives and/or diuretics. These are serious pathologies with little discussed prognosis, which, in turn, bring patients biopsychosocial damage and high levels of lethality, in addition to suffering for families. In this way, the present article brings the experience with an illustrative case of anorexia nervosa, thinking about its form of evaluation and intervention. Based on the reporting and recording models, the cognitive-behavioral therapist describes the contingencies of which a behavior is a function, its beliefs and life history. Such information can help to understand the development of anorexia, and thus teach the patient ways to manage the disorder.
Pengembangan Media Pembelajaran E-komik IPA Pada Materi Sistem Pencernaan Manusia Untuk Siswa kelas VIII SMP
Authors: Kasih Putri Pancar , Muhaimin Muhaimin , Hariyadi Bambang
Published: April 2022

Media is one of the important components that must exist in a learning process. The aim of this research is to develop science e-comic for human digestive system material for VIII-grade junior high school students. This study uses the ADDIE development model (Analysis, Design, Development, Implementation, and Evaluation). The data collection instrument used in the form of a validation questionnaire of design experts, material experts, teacher perceptions, and student perceptions of science e-comics. This research was conducted at SMP Insan Madani Boarding School Jambi. The results of validation by material experts obtained a percentage of 90.67% (very valid) and the assessment of media experts obtained a percentage of 90% (very valid). Assessment by the teacher obtained a percentage of 93.125% (very good). The results of the one-on-one trial obtained a total score of 96.67% (very good), the small-group trial scored 94.33% (very good), and the large group trial obtained a score of 92% (very good). In conclusion, science e-comic learning media is suitable for use in distance learning (online).
Key words: Learning Media, E-Comic, Human Digestive System
 
Abstrak. Media merupakan salah satu komponen penting yang harus ada di dalam suatu pembelajaran. Tujan penelitian ini adalah mengembangkan e-komik IPA materi sistem pencernaan manusia untuk siswa kelas VIII SMP. Penelitian ini menggunakan model pengembangan ADDIE (Analysis, Design, Development, Implementation, and Evaluation). Instrumen pengumpulan data yang digunakan berupa angket validasi ahli desain, ahli materi,  persepsi guru dan persepsi siswa terhadap e-komik IPA. Penelitian ini dilakukan di SMP Insan Madani Boarding School Jambi. Hasil validasi oleh ahli materi memperoleh persentase 90,67% (sangat valid) dan penilaian ahli media memperoleh persentase 90% (sangat valid). Penilaian oleh  guru  memperoleh   persentase 93,125% (sangat baik). Hasil uji coba satu-satu diperoleh skor total 96,67% (sangat baik), uji coba kelompok kecil memperoleh nilai 94,33% (sangat baik), dan uji coba kelompok besar memperoleh nilai 92% (sangat baik). Kesimpulannya media pembelajaran e-komik IPA  layak digunakan dalam pembelajaran jarak jauh (daring).
Kata kunci: Media Pembelajaran, E-komik, Sistem Pencernaan Manusia
BRITISH WRITERS AND THE MALAYS: TWO SIDES TO A COIN
Authors: Embong Abdul Mutalib , A. Kadhim Kais , Abdullah Nurul Ain Chua , Fan Tan Yi , Abdul-Kadir Nurul Ashikin , Pham Loi Hoang Huy Phuoc
Published: April 2022

Abstract The Tanah Melayu, or land of the Malays, was one of the colonies conquered by the British as early as the 17th century. The historical impact of colonialism on the social, economic and cultural experiences of the native Malays has been welldocumented. This paper attempts to explore several ideas of organic intellectuals and the subjugation of the Malays from the perspective of the colonialists. For this study, various literary works penned by British scholars and commoners were analysed. These works were then divided into a few sub-themes encompassing the sociological aspects of the Malays. The findings were empirically inaccurate due to the lack of suitable approaches to fortify analyses of the Malays. In some cases, the scholars’ opinions are almost intangible and amateurish, which could cause confusion and prejudice. The British writers were also found to have produced literary works about the Malays based on what they had seen in specific locations, which may not have shown the full perspective of the ethnic group. The writers also might have ignored certain ethical points during writing. The study also unmasked the motives and British discourse on the Malays. This can provide a better understanding of European intellect toward the integrity of the Malays. Keywords: British, British writers, Malays, images, colonials. Abstrak Tanah Melayu merupakan salah satu dari tanah jajahan British sejak awal abad ke-17. Sejarah serta kesan penjajahan sama ada dalam bentuk pengalaman sosial, ekonomi dan budaya penduduk asal Melayu didokumentasikan dengan baik dalam karya bertulis. Makalah ini membincangkan berkaitan beberapa idea golongan intelektual organik Melayu daripada perspektif penjajah. Beberapa karya sastera yang ditulis oleh sarjana British dan rakyat biasa juga dianalisis dalam kajian ini. Karya-karya tersebut dibahagikan kepada beberapa subtema yang merangkumi aspek sosiologi Melayu. Secara empirikal, penemuan kajian kurang tepat disebabkan kekurangan pendekatan terhadap bahan yang amat diperlukan bagi menguatkan analisis subjek, iaitu orang Melayu. Dalam sesetengah kes, pendapat itu hampir tidak ketara serta banyak mengelirukan dan menimbulkan prejudis. Penulis British menulis berdasarkan sesuatu yang mereka lihat di kawasan tertentu dan tidak mewakili keseluruhan penduduk. Beberapa prinsip moral yang mengawal tingkah laku etika dalam penulisan mungkin diabaikan. Selain itu, makalah ini juga menyingkap motif dan asas wacana British tentang orang Melayu yang boleh memberi pemahaman yang lebih baik tentang tindak balas intelektual Eropah terhadap kewibawaan orang Melayu. Kata Kunci: British, penulis British, orang Melayu, imej, kolonial.
Global well-posedness for the fourth-order Schrödinger equation with Hartree-type nonlinearity for Cauchy data in Lp
Authors: Xie Jin , Wang deng , Yang Han
Published: April 2022

This paper is concerned with the Cauchy problem for the nonlinear
fourth-order Schrödinger equation on R^{n}, with the nonlinearity
of Hartree-type (|
·|^{-γ}∗|u|^{2} )u .It is shown
that a global solution exists for initial data in the spaces L^{p}
(p < 2) under somesuitable conditions on γ, n and p. The
solution is established by using a data-decomposition argument, two
kinds of generalized Strichartz estimates and a interpolation theorem.
MaxSpliZer: a Tool to Predict Effects of Splice Variants Based on the Maximum Entropy Model
Authors: Saadatagah Seyedmohammad , Shahnazar Reza , Sherafati Alborz , Alhalabi Lubna , Miller Alexandra A. , Hamed Marwan , Kullo Iftikhar
Published: April 2022

The Clinical Genome Resource Consortium (ClinGen) recommends MaxEntScan
(MES) model to predict effects of LDLR splice variants. We
developed “MaxSpliZer”, a software tool to automate implementation of
MES and validated it using ClinVar and UK-Biobank (UKBB) data. We tested
concordance of MaxSpliZer predictions with ClinVar classifications of
pathogenicity of variants in LDLR and FBN1 with potential
effect on splicing. We also annotated LDLR splice variants in
200,618 UKBB participants, categorizing them using MaxSpliZer as
deleterious (n=90) and non-deleterious (n=7,404). Low-density
lipoprotein cholesterol (LDL-C) levels were compared in these two groups
after adjustment for lipid lowering medication use. MaxSpliZer
prediction was concordant with the ClinVar classification in 96% of
LDLR variants and 98% of FBN1 variants. In the UKBB,
splice variants predicted as deleterious by MaxSpliZer had higher LDL-C
than non-deleterious splice variants (158.7±47.4 vs. 146.0±34.8mg/dL,
p-value = 0.014). Compared to manual curation time of 12±7 min per
variant, MaxSpliZer took 0.52±0.11 min for single entries and 1.5 s per
variant for biobank-scale data. MaxSpliZer, a software tool that
implements MES based on the ClinGen guideline, can accurately classify
splice variants in a rapid automated fashion.
Giant Coronary Artery Ectasia and its Management: A Case Report
Authors: Memon Rahat Ahmed , Amin Muhammad , Kumar Satesh , Khatri Mahima
Published: April 2022

Background: Coronary artery aneurysms are reported in 1.5 to
4.9 percent of the population receiving coronary angiography. Whether
there is coronary stenosis or atrial fibrillation, it might result in an
acute coronary syndrome. Case presentation: The patient was in
his usual health when he began to experience pain while watching
television an hour before his visit to the emergency department
. The patient, a smoker with a history of hypertension,
presented at our hospital with significant retrosternal chest pain. A CT
angiography of the coronary arteries revealed a large RCA aneurysm
thrombus-laden aneurysm. He was given 324 mg aspirin, 400 mcg
Nitro-glycerin, 80 mg Atorvastatin, and a Heparin infusion immediately.
An emergency RCA bypass grafting procedure was performed after a
cardiothoracic surgical team assessed the patient. Conclusion:
Coronary artery aneurysm is an infrequent disorder that can appear in a
variety of ways. Before any further therapy, it should be thoroughly
evaluated.
Oral mucositis in children with hematologic tumors undergoing chemotherapy: A case series
Authors: Santos Fabio dos , Bezerra Paula Maria , Limão Nayara Pereira , Santana Ynnaiana , Ribeiro Isabella , Bonan Paulo Rogério Ferreti , Sousa Simone , Valença Ana Maria Gondim
Published: April 2022

Oral mucositis (OM) is the most common local adverse event of
chemotherapy treatment and leads to a debilitating condition from the
patient’s perspective. The aim of this study is to report nine cases of
severe OM over 10 weeks after initiating chemotherapy in pediatric
patients with leukemia. All patients showed changes in normality of
hematological data in most week. The most used chemotherapeutic agents
were aracytin, etoposide and methotrexate. Saliva and lips were the most
affected items. Well-designed observational studies are needed to better
understand the risk factors for developing severe OM.
Association between elevated intrauterine resting tone during labor and neonatal morbidity: A secondary analysis of a prospective cohort study
Authors: Rimsza Rebecca , Raghuraman Nandini , Carter Ebony , Kelly Jeannie , Cahill Alison , Frolova Antonina
Published: April 2022

Objective: Internal contraction monitoring during the course of labor
may identify elevated intrauterine resting tone. Our objective was to
assess the association between elevated resting tone during labor and
neonatal morbidity. Design: Secondary analysis of a prospective cohort
study. Setting and Population: Term singleton patients with ruptured
membranes and an intrauterine pressure catheter in place: Tertiary care
hospital, United States of America Methods. Intrauterine resting tone
was calculated as the average baseline pressure between contractions.
The study group had elevated intrauterine resting tone, defined as
intrauterine resting tone ≥75th percentile. Main Outcome Measures:
Composite neonatal morbidity: hypoxic ischemic encephalopathy,
hypothermia treatment, intubation, seizures, umbilical arterial pH ≥
7.1, oxygen requirement, or death. Results: Of the 8580 patient in the
cohort, 2210 (25.8%) were included. The median intrauterine resting
tone was 9.7 mmHg (IQR 7.3-12.3 mmHg). Elevated resting tone was
associated with shorter median duration of the first stage of labor
(10.0 hrs vs 11.0 hrs, p <0.01) and lower rates of labor
induction (p < 0.01). Neonatal composite morbidity was higher
among patients with elevated intrauterine resting tone (5.1% vs 2.9%,
p=0.01). After adjusting for chorioamnionitis and amnioinfusion,
elevated intrauterine resting tone was associated with increased risk of
neonatal morbidity (aOR 1.70, 95% CI 1.06-2.74). Compared to normal
tone, elevated intrauterine resting tone was associated with mild
acidemia and elevated lactate (aOR 1.81, 95% CI 1.38-2.37 and aOR 1.45,
95% CI 1.17-1.80, respectively). Conclusion: Elevated intrauterine
resting tone is associated with increased risk of neonatal composite
morbidity. Funding: None
The Spatial Location of the Eavesdropper on the Secrecy Performance of FSOC System
Authors: Ma Jing , Wu Hongyu , Guo Pengzhen , kang dongpeng
Published: April 2022

In this paper, we analyze the spatial location of the eavesdropper on
the secrecy performance of free-space optical communication systems over
Fischer–Snedecor F-distribution fading channel. As a key feature, we
investigate the impact of the eavesdropper’s location within the range
of the beam divergence angle, which is more in line with practical
engineering applications. The possible position of the eavesdropper is
comprehensively assumed with horizontal and vertical components within
the beam divergence angle. To this end, the lower-band secrecy outage
probability, asymptotic solutions of SOP at high signal-to-noise-ratio,
and the strictly positive secrecy capacity are obtained in closed-form,
which are corroborated by exact Monte Carlo simulations respectively.
Bourdieu’s Language and Symbolic Power
Authors: Ajvazi Irfan
Published: April 2022

The concept of symbolic power was first introduced by French sociologist
Pierre Bourdieu to account for the tacit, almost unconscious modes of
cultural/social domination occurring within the everyday social habits
maintained over conscious subjects. Symbolic power accounts for
discipline used against another to confirm that individual’s placement
in a social hierarchy, at times in individual relations but most
basically through system institutions, in particular education.
Introduction of the IBR Jesus Group
Authors: BOCK DARRELL L. , WEBB ROBERT L.
Published: April 2022

The IBR Jesus Group is a working group drawn from members of IBR to explore the historicity and significance of key events in the life of Jesus. This essay explains the intent of the group and the distinctive "team" approach that it takes to the project.
"What Do These Stones Mean?": Biblical Theology and a Motif in Joshua
Authors: HUBBARD, ROBERT L.
Published: April 2022

The book of Joshua seems to contradict itself, praising Israel's complete conquest of Canaan while reporting the survival of Rahab and the Gibeonites. This paper responds to the problem by studying a recurrent motif in Joshua 3–10: a stone structure that memorializes past events "to this day" (used four times). The stones motif contributes to the literary coherence of the context around the theme of Yahweh's conquest of his enemies. More important, the stone structure at Gilgal (chaps. 3–4) hints that Canaanites besides Rahab might receive divine favor, while Achan's burial heap (chap. 7) suggests that Yahweh values obedience over ethnicity and welcomes religiously responsive foreigners. Similarly, the Gibeonite episode (chaps. 9–10) demonstrates divine acceptance of Israel's arrangement with Gibeon as an exception to the ḥerem mandate. Thus, Joshua 3–10 not only reports the survival of foreigners but also quietly advocates divinely-sanctioned exceptions to the mandate in certain cases. In this way, the perceived tension between the mandate and the survival of foreigners lessens. This article also explores the theological themes that the motif sounds and the model of biblical theology that underlies it.
1 Thessalonians 4:4: Breaking the Impasse
Authors: SMITH JAY E.
Published: April 2022

The crux interpretum τὸ ἑαυτοῦ σκεῦος κτᾶσθαι ἐν ἁγιασμῷ καὶ τιμῇ in 1 Thess 4:4 has traditionally been understood in one of three ways: (1) "acquire a wife for himself in holiness and honor" (NAB); (2) "live with your wife in a holy and honorable way" (TEV); and (3) "control your own body in holiness and honor" (NRSV). These three views are thoroughly evaluated, and new evidence, especially concerning the referent of σκεῦος as well as the semantic force of the present infinitive κτᾶσθαι, is brought to bear on the problem. This analysis suggests that by τὸ ἑαυτοῦ σκεῦος κτᾶσθαι ἐν ἁγιασμῷ καὶ τιμῇ Paul means that each one is to control his or her own body in holiness and honor or, perhaps more specifically, that each one is to control his or her sexual organ in holiness and honor.
Where Should Twenty-First-Century Evangelical Biblical Scholarship Be Heading?
Authors: BLOMBERG CRAIG L.
Published: April 2022

Recent developments and resulting needs are assessed in a variety of areas: historical Jesus research and issues of OT historicity, Pauline theology and theologies of individual OT books, critical methods for the study of both Testaments and especially historical study, contextualized biblical studies, biblical ethics, the application of the OT in the NT age and the quotation of the Old in the New, Greek and Hebrew grammar, OT textual criticism, and the interaction between church and the academy.
Jesus and the Twelve
Authors: MCKNIGHT SCOT
Published: April 2022

IBR Jesus Project Paper 2. That Jesus associated himself especially with twelve of his followers is a datum firmly established by good arguments across a broad spectrum of modern Jesus studies. But why Jesus chose the Twelve is in need of serious reconsideration because the standard, eschatological explanation has rarely been examined. A careful examination of the evidence pertaining to the number "twelve" in the Hebrew Bible and in ancient Jewish sources suggests that Jesus chose the Twelve to evoke the twin themes of covenant renewal (a Joshua theme) and eschatological restoration (with the reunification of the twelve tribes implied).
πάροικος καὶ παρεπίδημος: Proselyte Characterizations in 1 Peter?
Authors: SELAND TORREY
Published: April 2022

In some diaspora Jewish works, the terms πάροικος and παρεπίδμος belong to the semantic field of "proselyte/proselytism." In 1 Peter, however, they do not indicate that the recipients of the letter are considered former proselytes. The terms function rather as metaphors drawn from the social world of proselytes (source domain), characterizing the social situation of the Petrine Christians (target domain), especially throwing light on the social estrangement of the Christian converts in the Greco-Roman societies of Asia Minor as understood by the author.
Equilibrium and the Sacred Compass: The Structure of Leviticus
Authors: Walton John H.
Published: April 2022

Despite the highly organized features of Leviticus, interpreters have found it difficult to identify a cohesive structure to the book. One possible explanation may be that we have been deterred by presuppositions. We have generally seen the sacrificial system in terms of providing a means to care for the sin and impurity of the people. An alternative approach, however, focuses on the need to preserve and maintain sacred space. This paper builds on this concept and explores the ways that such an adjustment in our thinking suggests a new understanding of the structure and focus of Leviticus.
The Social Matrix of Women's Speech at Corinth: The Context and Meaning of the Command to Silence in 1 Corinthians 14:33b–36
Authors: PAIGE TERENCE
Published: April 2022

A reexamination of Greek and Roman culture highlights women's positive role in religion, as Paul also grants, as well as the nuanced but guarded interactions between the sexes. Paul's injunction to women in 1 Cor 14:34–35 was meant to prevent casual interaction between married women and non-family men in the context of worship, not to prevent sacral speech. This behavior was seen as sexually aggressive, bringing shame on these women and the church in society's eyes.
Paul in Arabia
Authors: HENGEL MARTIN
Published: April 2022

The few hints of Paul's time in Arabia (or Nabatea) are much more important than is suggested by the scant attention they typically receive in NT scholarship. Careful consideration of all factors leads to the conclusion that Paul's stay in Arabia was somewhat longer than is usually thought and resulted in successful missionary activity. However, this activity also provoked vigorous opposition on the part of synagogue authorities, as well as state authorities.
A Rejoinder to Joel F. Williams's "Is Mark's Gospel an Apology for the Cross?"
Authors: GUNDRY ROBERT H.
Published: April 2022

Against Joel Williams's critique, this rejoinder argues for a Markan Christology of divine strength in word and deed to counteract the shame of Jesus' crucifixion, thus to convert unbelievers, not a Christology of weakly human suffering designed to brace believers for the endurance of persecution. In his Gospel, Mark included material seemingly antithetical to such an apologetic, evangelistic aim because he felt obliged to write up everything he had heard Peter say about Jesus' ministry (so John the Elder). At the same time Mark tweaked this very material in ways that allied it to the massive amount of power-material (much underplayed by Williams) in service of the apologetic, evangelistic aim. Even Mark's passion narrative exhibits such tweaking, for example, in emphases on the fulfillments of Jesus' various predictions, on Jesus' dying with a burst of strength, and on the shortness of time he hung on a cross. This interpretation of Mark's text arose out of a close reading, not out of a presupposition.
MitofusinsMfn1andMfn2Are Required to Preserve Glucose- but Not Incretin-Stimulated β-Cell Connectivity and Insulin Secretion
Authors: Georgiadou Eleni , Muralidharan Charanya , Martinez Michelle , Chabosseau Pauline , Akalestou Elina , Tomas Alejandra , Wern Fiona Yong Su , Stylianides Theodoros , Wretlind Asger , Legido-Quigley Cristina , Jones Ben , Lopez-Noriega Livia , Xu Yanwen , Gu Guoqiang , Alsabeeh Nour , Cruciani-Guglielmacci Céline , Magnan Christophe , Ibberson Mark , Leclerc Isabelle , Ali Yusuf , Soleimanpour Scott A. , Linnemann Amelia K. , Rodriguez Tristan A. , Rutter Guy A.
Published: April 2022

Mitochondrial glucose metabolism is essential for stimulated insulin release from pancreatic β-cells. Whether mitofusin gene expression, and hence, mitochondrial network integrity, is important for glucose or incretin signaling has not previously been explored. Here, we generated mice with β-cell–selective, adult-restricted deletion knock-out (dKO) of the mitofusin genes Mfn1 and Mfn2 (βMfn1/2 dKO). βMfn1/2-dKO mice displayed elevated fed and fasted glycemia and a more than fivefold decrease in plasma insulin. Mitochondrial length, glucose-induced polarization, ATP synthesis, and cytosolic and mitochondrial Ca2+ increases were all reduced in dKO islets. In contrast, oral glucose tolerance was more modestly affected in βMfn1/2-dKO mice, and glucagon-like peptide 1 or glucose-dependent insulinotropic peptide receptor agonists largely corrected defective glucose-stimulated insulin secretion through enhanced EPAC-dependent signaling. Correspondingly, cAMP increases in the cytosol, as measured with an Epac-camps–based sensor, were exaggerated in dKO mice. Mitochondrial fusion and fission cycles are thus essential in the β-cell to maintain normal glucose, but not incretin, sensing. These findings broaden our understanding of the roles of mitofusins in β-cells, the potential contributions of altered mitochondrial dynamics to diabetes development, and the impact of incretins on this process.
Safety of Empagliflozin in Patients With Type 2 Diabetes and Chronic Kidney Disease: Pooled Analysis of Placebo-Controlled Clinical Trials
Authors: Tuttle Katherine R. , Levin Adeera , Nangaku Masaomi , Kadowaki Takashi , Agarwal Rajiv , Hauske Sibylle J , Elsäßer Amelie , Ritter Ivana , Steubl Dominik , Wanner Christoph , Wheeler David C.
Published: April 2022

Objective

To
assess safety of empagliflozin in patients with type 2 diabetes and moderate-to-severe
chronic kidney disease ([CKD] category G3–4) enrolled in clinical trials.

Research
Design and Methods

This analysis pooled data from 19 randomized,
placebo-controlled, phase 1–4 clinical trials and one randomized,
placebo-controlled extension study in which patients received empagliflozin 10 mg
or 25 mg daily. Time to first occurrence of adverse events (AEs) was evaluated using
Kaplan-Meier analysis and multivariable Cox regression models.

Results

Among
a total of 15,081 patients who received at least one study drug dose,1522,
722, and 123 individuals were classified as CKD categories G3A, G3B,
and G4, respectively, at baseline. Demographics and clinical characteristics
were similar between treatment groups across categories of CKD. Rates of serious
AEs, AEs leading to discontinuation, and events of special interest (including
lower limb amputations and acute renal failure [ARF]) were also similar between
empagliflozin and placebo across CKD subgroups. In adjusted Cox regression
analyses, risks for volume depletion and ARF were similar for empagliflozin and
placebo in the combined group with CKD categories G3B–G4 and the G3A group.
Notably lower risks (HR [95% CI]) were observed in both groups for hyperkalemia
(0.59 [0.37–0.96], P = 0.0323; and 0.48 [0.26–0.91], P = 0.0243,
respectively) and edema (0.47 [0.33–0.68], P < 0.0001; and 0.44 [0.28–0.68],
P = 0.0002, respectively).

Conclusions

Use of
empagliflozin in patients with type 2 diabetes and advanced CKD raised no new safety
concerns and may have beneficial effects on development of hyperkalemia and
edema.
β-Cell Succinate Dehydrogenase Deficiency Triggers Metabolic Dysfunction and Insulinopenic Diabetes
Authors: Lee Sooyeon , Xu Haixia , Vleck Aidan Van , Mawla Alex M. , Li Albert Mao , Ye Jiangbin , Huising Mark O. , Annes Justin P.
Published: April 2022

Mitochondrial dysfunction plays a central role in Type 2 Diabetes (T2D); however, the pathogenic mechanisms in pancreatic β-cells are incompletely elucidated. Succinate dehydrogenase (SDH) is a key mitochondrial enzyme with dual functions in the TCA cycle and electron transport chain (ETC). Using human diabetic samples and a mouse model of β-cell-specific SDH ablation (SDHBβKO), we define SDH deficiency as a driver of mitochondrial dysfunction in β-cell failure and insulinopenic diabetes. β-Cell SDH deficiency impairs glucose-induced respiratory oxidative phosphorylation and mitochondrial membrane potential (ΔΨm) collapse, thereby compromising glucose-stimulated ATP production, insulin secretion and β-cell growth. Mechanistically, metabolomic and transcriptomic studies reveal that the loss of SDH causes excess succinate accumulation, which inappropriately activates mTORC1-regulated metabolic anabolism, including increased SREBP-regulated lipid synthesis. These alterations, which mirror diabetes-associated human β-cell dysfunction, are partially reversed by acute mTOR inhibition with rapamycin. We propose SDH deficiency as a contributing mechanism to the progressive β-cell failure of diabetes and identify mTORC1 inhibition as a potential mitigation strategy. 
Mitofusins Mfn1 and Mfn2 are Required to Preserve Glucose- But Not Incretin-Stimulated Beta Cell Connectivity and Insulin Secretion
Authors: Georgiadou Eleni , Muralidharan Charanya , Martinez Michelle , Chabosseau Pauline , Akalestou Elina , Tomas Alejandra , Wern Fiona Yong Su , Stylianides Theodoros , Wretlind Asger , Legido-Quigley Cristina , Jones Ben , Noriega Livia Lopez , Xu Yanwen , Gu Guoqiang , Alsabeeh Nour , Cruciani-Guglielmacci Céline , Magnan Christophe , Ibberson Mark , Leclerc Isabelle , Ali Yusuf , Soleimanpour Scott A. , Linnemann Amelia K. , Rodriguez Tristan A. , Rutter Guy A.
Published: April 2022

Mitochondrial glucose metabolism is essential for stimulated insulin release from pancreatic beta cells.  Whether mitofusin gene expression, and hence mitochondrial network integrity, is important for glucose or incretin signalling has not previously been explored. Here, we generated mice with beta cell-selective, adult-restricted deletion of the mitofusin genes Mfn1 and Mfn2 (βMfn1/2 dKO). βMfn1/2 dKO mice displayed elevated fed and fasted glycaemia and a >five-fold decrease in plasma insulin. Mitochondrial length, glucose-induced polarisation, ATP synthesis, cytosolic and mitochondrial Ca2+ increases were all reduced in dKO islets. In contrast, oral glucose tolerance was more modestly affected in βMfn1/2 dKO mice and GLP-1 or GIP receptor agonists largely corrected defective GSIS through enhanced EPAC-dependent signalling. Correspondingly, cAMP increases in the cytosol, as measured with an Epac-camps based sensor, were exaggerated in dKO mice. Mitochondrial fusion and fission cycles are thus essential in the beta cell to maintain normal glucose, but not incretin, sensing. These findings broaden our understanding of the roles of mitofusins in beta cells, the potential contributions of altered mitochondrial dynamics to diabetes development and the impact of incretins on this process. 
HIF-2α Preserves Mitochondrial Activity And Glucose Sensing in Compensating Beta Cells in Obesity
Authors: Moon Jae-Su , Riopel Matthew , Seo Jong Bae , Herrero-Aguayo Vicente , Isaac Roi , Lee Yun Sok
Published: April 2022

In obesity, increased mitochondrial metabolism with the accumulation of oxidative stress leads to mitochondrial damage and beta cell dysfunction. In particular, beta cells express anti-oxidant enzymes at relatively low levels and are highly vulnerable to oxidative stress. Early in the development of obesity, beta cells exhibit increased GSIS, in order to compensate for insulin resistance. This increase in beta cell function under the condition of enhanced metabolic stress suggests that beta cells possess a defense mechanism(s) against increased oxidative damage, which may become insufficient or decline at the onset of type 2 diabetes. Here, we show that metabolic stress induces beta cell HIF-2a, which stimulates anti-oxidant gene expression (e.g. Sod2 and Cat) and protects against mitochondrial ROS and subsequent mitochondrial damage. Knockdown of HIF-2a in Min6 cells exaggerated chronic high glucose-induced mitochondrial damage and beta cell dysfunction by increasing mitochondrial ROS levels. Moreover, inducible beta cell HIF-2a KO mice developed more severe beta cell dysfunction and glucose intolerance on high fat diet, along with increased ROS levels and decreased islet mitochondrial mass. Our results provide a previously unknown mechanism for how beta cell defends against increased metabolic stress to promote beta cell compensation in obesity. 
Synchronous Papillary Thyroid Cancer and Lymph Node Tuberculosis in a Patient with Cervical Lymphadenopathy: Case Report and Review
Authors: Velasco José A. , Jaimes Edwing M. , Tovar Mariano P. , Reyes Greta G. , Martinez Saul J. , Mata Carlos J. , Monroy Miguel A. , Bustamante Ludwigvan A.
Published: April 2022

The incidence of thyroid cancer has increased in the last decade, with a mortality rate of 0.5 per 100,000 inhabitants, being papillary carcinoma as the most common histological type. Identify it synchronously with a case of lymph node tuberculosis (TBG) is extremely rare and a real challenge for its diagnostic suspicion. Tuberculous lymphadenitis is clinically indistinguishable from metastatic forms of papillary thyroid carcinoma and histopathologic examination is the most accurate test for diagnosis. In this paper we present the case of a 31-year-old male who presented cervical lymphadenopathy and a concomitant thyroid nodule, giving the impression of a metastatic thyroid tumor, who received treatment with total thyroidectomy and cervical lymph node dissection.