bluuebunny/crossref_metadata_2025 huggingface dataset:
Late Quaternary fluvial environments at Abo Arroyo, New Mexico, U.S.A.: response to millennial-scale climate change
Authors: Hall Stephen A.
Published: July 2023

Abo Arroyo is a tributary of the Rio Grande in central New Mexico. Its alluvial sequence is made up of four informal units, their age defined by 44 AMS radiocarbon dates from 12.8 ka to 0.85 ka. The earliest, unit 1, is terminal Pleistocene to early Holocene (12.8 ka to 9.0 ka), including the Scholle wet meadow (12.3 ka to 11.1 ka) related to the Younger Dryas. After an erosional gap in the record from 9 ka to 6 ka, coarse gravel (unit 2) was deposited in the channel (5.8 ka and 4.3 ka) during the middle Holocene period of aridity. Subsequently, the late Holocene wet period is characterized by fine-textured alluvium (unit 3) (3.5 ka to 0.945 ka) with shells of an aquatic snail, indicating persistent stream flow. An upper 2-m zone of dark-colored clayey silt beds with high amounts of organic carbon and carbonate accumulated from 1.7 ka to 0.945 ka. A record of C4 signatures, previously interpreted to indicate dry conditions 1.4 ka to 0.945 ka, is reinterpreted as an interval of exceptionally wet floodplain conditions with C4 grasses and sedges. Abo Arroyo and other studies indicate three major episodes of late-Quaternary channel entrenchment: 1) from the full-glacial to late glacial-Bølling/Allerød (6.1 ky), 2) during the middle Holocene (2.5 ky), and 3) during the late Holocene Medieval Warm Period (0.4 ky), each erosional event less severe and shorter duration than the preceding one, and all three represent a significant change from wet to dry climate. During the Medieval Warm Period (A.D. 900 to 1300), a shallow channel formed in unit 3 alluvium, bracketed by AMS dates A.D. 1005 in unit 3 alluvium and A. D. 1100 in unit 4 channel fill. The channel cutting occurred with the shift from wet to dry climate, although the downcutting event was preceded by 100 years of landscape adjustment to the long drought. The canyon fill was entrenched again, deep and wide, by arroyo cutting in the late nineteenth and early twentieth centuries. The regional 83-year second-century drought (A.D. 100 to A.D. 182), documented by tree rings, shows up in the stable-carbon-isotope record from Abo Arroyo alluvium. The drought was more severe than the 400-year warm period but had little effect on the preserved alluvial record. The less severe but longer-duration Medieval Warm Period resulted in channel cutting at Abo Arroyo and elsewhere in the broad region at that time, but the second-century drought did not. Finally, the similarity of Abo Arroyo and Rio Grande late Holocene alluvial records with parallel stratigraphy, sedimentology, and geochronology illustrates that tributaries and main valleys respond alike and in concert to climate and climate change.
Innovative low-cost engineered adsorbents based on waste eggshell for nickel removal from aqueous solutions
Authors: SEGNEANU Adina-Elena , TRUSCA Roxana , CEPAN Claudiu , MIHAILESCU Maria , GROZESCU Ioan , MUNTEAN Cornelia , HEREA Daniel Dumitru , SALIFOGLOU Athanasios
Published: July 2023

In contemporary sustainable economy, innovation is prerequisite to waste recycling into new efficient materials, designed to minimize pollution and conserve non-renewable natural resources. Water pollution is a global problem with health, quality of life, and food safety concerns. Thus, waste conversion into cheap, efficient adsorbent materials with high reusability is a challengein wastewater recycling. In that context, starting from eggshell waste in this study, two new low-cost engineered adsorbents were prepared for the retrieval of nickel from aqueous solutions. Scanning electron microscopy (SEM) results show that, in the first eggshell-zeolite (EZ) adsorbent, the zeolite nanoparticles were loaded in the eggshell pores. The preparation for the second (iron(III) oxide-hydroxide)-eggshell-zeolite (FEZ) adsorbent led to double functionalization of the eggshell base with the zeolite nanoparticles, upon simultaneous loading of the pores of the eggshell and zeolite surface with FeOOH particles. Structural modification of the eggshell led to a significant increase of the specific surface, as confirmed by BET analysis. These features enabled the proposed adsorbents (EZ and FEZ) to remove nickel from aqueous solutions with high performance and adsorption capacities 321.1 mg/g and 287.9 mg/g, respectively. The results indicate that nickel adsorption on EZ and FEZ is a multi-molecular layer, spontaneous, and endothermic process. Concomitantly, desorption results reflect high reusability of these two adsorbents, collectively suggesting the use of waste in the design of new, low-cost, and highly efficient engineered adsorbents for environmental bioremediation
The nocturnal swarming activity of the malaria mosquito Anopheles coluzzii: it’s not just the males.
Authors: Vielma Sofia , Minuz Roxana , Trusso Alessandro , Sawadogo Simon , Cribellier Antoine , Diabaté Abdoulaye , Muijres Florian , Simoni Alekos , Müller Ruth
Published: July 2023

Anopheles gambiae sensu lato is the primary malaria vector, endemic to the African continent and has been found to mate in large swarms. To date, the spatial-temporal characterization of mosquito swarms has been restricted to male-focused interactions and relying on visual observations of field events during sunset. We recorded large-cage laboratory simulated swarm events of Anopheles coluzzii with Photonic Fence Monitoring Device (Photonic Sentry, USA) to characterize various spatial-temporal aspects of male, female, and mixed-sex swarms prior and posterior sunset. Results suggests that male and female mosquitoes form swarms in a spatially similar manner with no visible structural and physical variations within the tested groups. The study of temporal dynamics of swarms reveals a unique composition of swarm hotspot formation for up to one hour in total during night, which is contrary to literature. Our results challenge the paradigm that female mosquitoes are acting as reactive individuals to male activity only. We demonstrate that females can form stable and comparable swarms to those of only males or mixed sex, at least under laboratory conditions. This discovery merits further research regarding the purpose of female swarming activity and the missing field observations of females during sunset.
My Diet Study: A Protocol for An Observational, Longitudinal, Cross-Sectional Psycho- Biological Study of Dieting in Young People
Authors: Okada Mirei , Pehlivan Melissa , Miskovic-Wheatley Jane , Barakat Sarah , Griffiths Kristi , Touyz Stephen , Simpson Stephen J. , Maguire Sarah , Holmes Andrew
Published: July 2023

Background
Self-directed dieting (i.e., unsupervised) is very common among adolescents and young adults but has had almost no direct research. This paper describes the protocol for the My Diet Study, a two-arm observational investigation of the natural progression of dieting among young people over a period of 6-months. The study aims to examine the links between self-directed dieting, general physiological and psychological metrics of wellbeing (e.g., depressive symptoms) and biomarkers of gut-brain axis functions (e.g., microbiome and hormones) that are predicted to influence diet adherence through appetite, mood and metabolism regulation.
Methods
Young people aged 16-25, intending to start a diet will be invited to participate in this observational study. For Part 1 (psychological arm), participants will be asked to complete a set of questionnaires and diaries at the beginning of every month for 6 months, to assess overall mental (e.g., psychological distress, disordered eating) and physical (e.g., weight) health, perceived diet success, food intake and gastrointestinal movements. For Part 2 (biological arm), a subsample of 50 participants will be asked to provide faeces, blood and saliva for bio-sampling each month for the first 3-months of their participation in Part 1.
Discussion
The My Diet Study will be the first longitudinal, observational study of dieting in young people combining in-depth psychological and biological data. It is anticipated that the findings will yield psychological & biological information about the impacts and effectiveness of self-directed dieting in young people, inform a framework for advice on safety in dieting among young people and help to establish the potential for biomarkers for risk management and improvement of diet-based lifestyle interventions.
Resumption of intravenous anti-cancer therapy in breast cancer: a real-world experience during the SARS-CoV-2 pandemic
Authors: Yang Fang , Li Cong , Qiu Yuling , Chen Xinjie , Zheng Kelin , Kang Donglin , Zhang Yin , Liu Baorui , Yao Yongzhong , Xie Li
Published: July 2023

Purpose
The coronavirus disease-2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, has delayed medical consultations, especially for patients receiving intravenous anti-cancer therapy. We aimed to investigate alterations in immune function among breast cancer patients who experienced delayed intravenous therapy due to SARS-CoV-2 infection.
Methods
We performed an observational investigation of breast cancer patients in Nanjing Drum Tower Hospital from December 27, 2022 to January 20, 2023. The patients recovered from SARS-CoV-2 infection were eligible for enrollment. Peripheral blood samples were taken prior to the restart of intravenous anti-cancer therapy to examine hematologic parameters.
Results
A total of 131 patients were included in the final analysis. Cough (74.0%), fever (62.6%), and expectoration (46.6%) were identified as the most presenting symptoms of SARS-CoV-2 infection in breast cancer. The average nucleic acid conversion time and delayed treatment time was 13.4 days and 13.9 days, respectively. The patients > 60 years old experienced prolonged nucleic acid conversion time (P = 0.017) and delayed treatment time (P = 0.028) compared to those < = 60 years old. Dysregulated lymphocyte subsets and cytokines were found post-SARS-CoV-2 infection. Treatment-related adverse events of grade 3 or 4 occurred in 7.6% after resuming intravenous anti-cancer therapy.
Conclusions
Our findings reveal that the SARS-CoV-2 infection led to imbalanced immune responses and postponed intravenous anti-cancer therapy in breast cancer. The safety report encourages the timely resumption of intravenous anti-cancer therapy after adequately weighing the risks and benefits.
Are TERT promoter mutations a poor prognostic factor in anaplastic thyroid carcinoma?
Authors: Ryu Hyun Jin , Oh Young Lyun , Heo Jung , Park Hyunju , Kim Tae Hyuk , Kim Sun Wook , Chung Jae Hoon
Published: July 2023

Purpose
Telomerase reverse transcriptase (TERT) promoter mutations are a poor prognostic factor in differentiated thyroid carcinoma (DTC). However, their prognostic value in anaplastic thyroid carcinoma (ATC) is unclear. Therefore, we investigated whether TERT promoter mutations also act as an independent poor prognostic factor in ATC.
Methods
We reviewed the medical records of 28 patients with ATC who underwent the TERT promoter mutations test at Samsung Medical Center between November 1995 and May 2020. The aggressive treatment group was defined as patients who underwent surgery, external radiotherapy, and systemic therapy.
Results
Among 28 patients, TERT promoter mutations were found in 10 patients (35.7%). There were no differences in the clinicopathological characteristics between the TERT-mutant and wild-type groups except tumor size and treatment modality. Median tumor size in the TERT-mutant group was 5.9 cm (3.7–11.0), which was significantly larger than that in the wild-type group (4.2 cm, 0.8–6.8, P = 0.006). Aggressive treatment was performed more frequently in the TERT-mutant group (60.0% vs. 22.2%, P = 0.046). The median overall survival (OS) was 6.9 months (0.4–39.5). The OS of the TERT-mutant group was longer that of than the wild-type group, but the difference was not significant (9.1 months [0.4–39.5] vs. 6.1 months [0.4–39.0], P = 0.432). In multiple regression analysis, old age (≥ 68.5 years), lymph node metastasis, and distant metastasis were significant prognostic factors, but TERT promoter mutations were not.
Conclusion
Unlike DTC, TERT promoter mutations were not an independent poor prognostic factor in ATC.
Propyl gallate induces cell death in human pulmonary fibroblast through increasing reactive oxygen species levels and depleting glutathione
Authors: Park woo hyun
Published: July 2023

Background Propyl gallate (PG) has demonstrated anti-growth effects on various cell types. This study aimed to investigate the impact of PG on reactive oxygen species (ROS) and glutathione (GSH) levels in primary human pulmonary fibroblast (HPF) cells. Additionally, the study explored the effects of N-acetyl cysteine (NAC), L-buthionine sulfoximine (BSO), and small interfering RNA (siRNAs) targeting antioxidant genes on ROS, GSH levels, and cell death in PG-treated HPF cells. Methods and Results Intracellular ROS and GSH levels were measured using different fluorescent probe dyes (H2DCFDA, DHE, MitoSOX™Red and CMFDA) through flow cytometer analysis. PG treatment at concentrations ranging from 100 to 800 µM resulted in increased levels of total ROS and O2•−at early time points (30–180 min and 24 h). Higher concentrations of PG (800–1600 µM) led to an increased number of cells depleted of GSH at 24 h and reduced GSH levels at 30–180 min. PG treatment downregulated the activity of superoxide dismutase (SOD) and upregulated the activity of catalase in HPF cells. Treatment with 800 µM PG increased the number of apoptotic cells and cells with loss of mitochondrial membrane potential (MMP; ∆Ψm) as assessed by Annexin V-FITC/PI and rhodamine 123 staining, respectively. NAC treatment mitigated PG-induced cell death and loss of MMP in HPF cells, accompanied by a decrease in GSH depletion. Conversely, BSO exacerbated cell death and MMP loss induced by PG, independent of ROS and GSH depletion levels. Following transfection with siRNA, the HPF cells were exposed to PG treatment. The siRNAs against SOD1, SOD2, and catalase successfully attenuated cell death in PG-treated HPF cells. In contrast, siRNA against GSH peroxidase enhanced cell death. Conclusions PG induced cell death in HPF cells by increasing ROS levels and depleting GSH. NAC was found to decrease HPF cell death induced by PG, while BSO enhanced cell death. The findings suggest that modulating the antioxidant defense system can influence the cytotoxic effects of PG in HPF cells.
Genome-wide genetic mutations accumulated in genome-edited pigs and their filial generation for xenotransplantation
Authors: Du Xiaoyan , Huo Xueyun , Sun Xianhui , Xing Xiangyang , Lu Jing , Zhang Jingjing , Jiang Yanyan , Zhu Xiao , Li Changlong , Lv Jianyi , Guo Meng , Cao Lixue , Liu Xin , Chen Zhenwen , Pan Dengke , He Shunmin , Zhang Chen
Published: July 2023

Although xenotransplantation has revolutionarily developed based on the usage of genome-edited pigs, it is still unknown whether these pigs and their offspring remains genomic stable. Here, we show that GGTA1-knockout (GTKO) pigs accumulated an average of 1205 genome-wide genetic mutations, and their filial 1 offspring contained an average of 18 de novo mutations compared with wild control and their parents, respectively. The majority of mutations were annotated in intergenic regions without altering protein functions and predicted off-target mutations. RNA-sequencing analysis and phenotype observation indicated that accumulated mutations may have a limited influence on GTKO pigs and most genetic mutations in GTKO pigs can be explained by electrotransfection of plasmids into cells. This is the first report that the genetic mutations of genome-edited pigs are inherited stably by their filial generation and provide a reference for safe application and the standard approach to breeding genome-edited pigs for xenotransplantation.
High-throughput sequencing unveils HBV DNA integration and its oncogenic role in gastric cancer
Authors: He Yifu , Li Mengge , Wu Shushen , Niu Jiayu , Luo Huiqin , Chen Wenju , Cao Lulu , Yan Ying
Published: July 2023

Growing evidence showed an association between hepatitis B virus (HBV) infection and gastric cancer (GC). HBV DNA integration is one of the key mechanisms contributing to hepatocellular carcinoma (HCC) development. However, the status of HBV integration in GC has not been studied yet. In this study, HBV DNA was detected in 7/10 GC and 8/10 para-tumor tissues. By high-throughput viral integration detection and long-read sequencing, a total of 176 and 260 HBV integration breakpoints were identified from GC and para-tumor tissues, respectively. In the HBV genome, the breakpoints were more frequently occurred at X gene and C gene. In the host genome, these breakpoints distribution was correlated with CpG islands. Seven protein-coding genes and one non-coding RNA genes were inserted by HBV DNA for more than once in different samples. Combined with the bioinformatics analysis and functional experiments, we highlight SPRY3 and CHD6, as potential driver genes for GC. Besides, we also revealed the spatial relationship of HBV integration and its various structural variations. Taken together, our results first indicated that HBV DNA can integrate in GC. These findings provide insight into the HBV integration and its oncogenic progression in GC.
Developing Global Open Access COVID-19 Education for Frontline Healthcare Workers
Authors: Christianson Jacqueline , Frank Erica , Keating Stacen , Chickering Miriam
Published: July 2023

Background: Early in the Covid-19 pandemic, we identified a heightened need for a reliable, high-quality, accessible, and evidence-based educational resource for frontline healthcare workers. Open access virtual education can reduce disparities in access to education by minimizing cost barriers and providing equitable access to educational content. Our team of global healthcare educators responded by creating an open access competency-based online course to address access disparities around Covid-19 information. The course was aimed toward frontline healthcare workers globally and included design elements such as a built-in language translation tool and non-linear course design to facilitate access and address the individual’s educational needs.
Methods: Pre- and post-course surveys were collected to evaluate how the course addressed learner needs. Data were collected between the course launch in April 2020 through December 2020.
Results: An initial population of students (N=149) ranging from high school through doctoral education, living in 23 different countries, speaking 22 different native languages took the course and participated in the pre- and/or post-course surveys. Overall, participants rated the course highly.
Conclusion: Open access educational models can facilitate equitable access to education for a global audience.
Population-based Evidence for Using Serum Neurofilaments as Individual Diagnostic and Prognostic Biomarkers in Amyotrophic Lateral Sclerosis
Authors: Witzel Simon , Huss André , Nagel Gabriele , Rosenbohm Angela , Rothenbacher Dietrich , Peter Raphael , Baezner Hansjörg , Boertlein Axel , Dempewolf Silke , Schabet Martin , Hecht Martin , Kohler Andreas , Opherk Christian , Naegele Andrea , Sommer Norbert , Lindner Alfred , Alexudis Christoforos , Bachhuber Franziska , Halbgebauer Steffen , Brenner David , Ruf Wolfgang , Weiland Ulrike , Mayer Benjamin , Schuster Joachim , Dorst Johannes , Tumani Hayrettin , Ludolph Albert
Published: July 2023

Neurofilaments are biomarkers for neuroaxonal damage and are being evaluated in Amyotrophic Lateral Sclerosis (ALS) to support diagnosis, estimate prognosis, and monitor treatment effects. This study presents data on serum neurofilament levels in ALS on a population level to improve their application as individual diagnostic and prognostic biomarkers. We measured neurofilament light (NfL) and phosphorylated heavy chain (pNfH) levels in a large cohort of patients with ALS and controls from the epidemiological ALS registry Swabia. We observed that serum NfL was superior to pNfH. Using NfL Z-Scores instead of raw data and incorporating ALS-independent and ALS-specific influencing factors improved the diagnostic and prognostic ability. The high predictive value and individual longitudinal validity of serum NfL indicate its utility as an individual surrogate marker for survival and disease progression. Combiningepidemiological data and biomarker research in population-based Z-Scores might be a conceptual model of interest for other neurodegenerative diseases.
The solution comparison of fractional Heat transfer and porous media equations using analytical techniques
Authors: Khan Shahbaz , Sohail Muhammad , Khan Hassan , Tchier Fairouz , Omid Mohammad yar , Nadeem Muhammad
Published: July 2023

In this paper, the mathematical model related to the physical problem of electrostatic or gravitational area in the fractal domain is the Poisson equation, which analyses the potential area arising from a given charge with the possibility of the area identified being considered in fractional form. The Laplace residual power series method and the Laplace Adomian decomposition technique are used to compare the solutions of the fractional local Poisson equation. The phenomenon of electromagnetic mechanisms is typically modelled using elliptic partial differential equations. Furthermore, the Poisson equation is examined using the concept of fractional local derivative. For this reason, a few examples are presented to understand the fractional local Poisson equation in its more accurate form. The results show the simple and sophisticated procedures of the two proposed analytical approaches where partial differential equations are considered with fractional derivatives or local derivatives. The outcomes of the described methods demonstrate that they have an accurate algorithm to construct with exceptionally precise cost calculation capabilities. The present research is more related to the fractional local Poisson equation and also to the fractional local derivative of the Poisson equation, which produces pleasing results.
Proteomic Biomarkers for Survival in Systemic Sclerosis-associated Pulmonary Hypertension
Authors: MISMETTI Valentine , DELAVENNE Xavier , MONTANI David , BEZZEGHOUD Souad , DELEZAY Olivier , HODIN Sophie , Launay David , MARCHAND-ADAM Sylvain , NUNES Hilario , Ollier Edouard , REYNAUD-GAUBERT Martine , Pastre Jean , TRACLET Julie , QUETANT Sébastien , ZEGHMAR Sabrina , BERTOLETTI Laurent , COTTIN Vincent
Published: July 2023

BACKGROUND:interstitial lung disease (ILD) and pulmonary hypertension (PH) represent the major causes of mortality in systemic sclerosis (SSc). Patients with systemic sclerosis and combined PH and ILD (SSc–PH-ILD) generally have a poor prognosis. Predictors of survival and of potential benefit of treatment are lacking in patients with SSc-PH-ILD.OBJECTIVE:To identify specific plasma protein expression patterns associated with survival in patients with SSc-PH-ILD.MATERIALS AND METHODS:Post-hoc analysis of a prospective multicenter French study in patients with PH-ILD. An untargeted proteomic analysis using mass spectrometry was performed to identify plasma protein changes associated with long-term overall survival in patients with SSc-PH-ILD.RESULTS:Thirty two patients were included in the analysis, of whom 13 died during follow-up (median survival: 76.5 months). At baseline, survivors had less severe hemodynamic impairment (pulmonary vascular resistance of 4.4 Wood Units [IQR 3 - 5.2] vs. 6.2 Wood Units [IQR 4.2 - 10.7]) and higher carbon monoxide diffusing capacity (median 39% [IQR 35% - 44%] vs. 25% [IQR 22% - 30.5%]), than the 13 patients who died. Seven proteins, associated with haemostasis and fibrosis, were differentially expressed according to patients’ survival. In the survivor group, two proteins were increased (ADAMTS13, SERPIND1) and five were decreased (PTGDS, OLFM1, C7, IGFBP7, FBN1) compared to the non-survivor groups.CONCLUSION:The prognosis of SSc-PH-ILD patients is poor. This proteomic approach found 7 plasma proteins (involved in haemostasis and fibrosis pathways) associated with survival. These potential biomarkers may be good candidates to prognostic enrichment.
Deciphering Tumor Metastasis and Immune Inhibitory Signature of Clear Cell Renal Cell Carcinoma by Single-Cell Transcriptome Analysis
Authors: Yin Xinbao , Wang Ying , Wang Ke , Zhu Guanqun , Zhang Zongliang , Zhao Kai , Zhang Shaojun , Shi Benkang
Published: July 2023

Clear cell renal cell carcinoma (ccRCC) is known for its high heterogeneity and tendency to metastasize through the bloodstream, leading to limited treatment options and poor overall survival rates. To overcome these challenges, it is crucial to acquire a comprehensive understanding of the underlying biology of ccRCC. Therefore, we conducted a thorough analysis using single-cell RNA sequencing data obtained from samples of non-metastatic and metastatic ccRCC. Our analysis revealed significant differences in the composition of infiltrating immune cells within the primary tumor lesions between metastatic and non-metastatic ccRCC cases. Additionally, we identified two distinct tumor cell states, particularly proximal tubule cells, which exhibited significant enrichment in metastatic ccRCC cases. We found that MDK was highly expressed in metastatic ccRCC and exhibited significant prognostic value for patients. In metastaic ccRCC, we observed enhanced interactions between tumor cells and macrophages mediated by MDK, resulting in the polarization of macrophages towards an angiogenic and immune-suppressive M2-like phenotype. Furthermore, we observed notable differences in the interactions between macrophages and CD8 + T cells in non-metastatic and metastatic ccRCC. Metastatic ccRCC exhibited stronger interactions mediated by immune inhibitory molecules such as SPP1 and CD24, potentially contributing to immune suppression within tumor microenvironment. These dignificant findings provide valuable insights into the molecular and cellular signatures associated with metastatic ccRCC. Moreover, they open up promising opportunities for the development of novel biomarkers and therapeutic targets, specifically tailored to address the challenges posed by metastatic ccRCC.
Developing generic skills for future health professionals: Student and faculty perceptions of a Recovery College curriculum and courses
Authors: Zouaoui Inès , Drolet Marie-Josée , Briand Catherine
Published: July 2023

As healthcare systems worldwide grapple with complex challenges such as limited resources, qualified personnel shortages, and rapid technological advancements, there is an urgent need for educational transformation in healthcare professions. This urgency arises from the necessity for healthcare professionals to evolve beyond traditional roles and acquire essential generic skills such as adaptive, epistemic, relational, ethical, and citizenship skills - areas identified as gaps in conventional university curricula. This study investigates the potential of the Recovery College model, integrated into a Canadian university's healthcare curriculum, to address these gaps. Through qualitative group interviews with eight students and three faculty members, and subsequent descriptive content analysis, we explored the perceived outcomes of this model. We discerned 15 themes within the five core categories of generic skills (Epistemic, Ethical, Relational, Adaptative, and Citizenship skills), with "experiential knowledge acquisition" central to the training input, and other significant themes including "ethical sensitivity", "collaborative communication", "self-care", and "open-mindedness to diversity". Our findings highlight the Recovery College model's potential in fostering these crucial skills among future healthcare professionals and challenging prevailing epistemic injustices in healthcare. Further investigations are needed to understand the long-term effects of this model on healthcare practice and to explore its potential integration into wider healthcare education programs.
SST-MIS: Semi-STDP Optimized Medical Image Segmentation Using Modified Swin-Transformer and Pyramid Model
Authors: Chen First Zidong , Hassan Second Fadratul Hafinaz
Published: July 2023

This article presents a medical image segmentation model based on a semi-STDP (Spike-Timing-Dependent Plasticity) optimization strategy. The study utilizes a modified Swin-Transformer as the feature extraction module and combines it with a pyramid model. The STDP is employed to optimize the semi-segmentation results generated by the pyramid model, achieving precise segmentation of medical images. The architecture and features of the modified Swin-Transformer are described in detail, highlighting its excellent performance in feature extraction. Next, the design concept of the pyramid model is introduced, which can extract and fuse features at different scales to enhance the accuracy and robustness of the segmentation results. Furthermore, an innovative neural network module called the STDP-based segmentation module is proposed. The proposed model is experimentally validated using two medical image datasets and compared with other classical medical image segmentation methods. The experimental results demonstrate significant improvements in accuracy and robustness, validating the effectiveness of the semi-STDP optimization strategy and the superiority of the proposed model. Finally, in-depth analysis and discussion of the experimental results are provided, along with prospects for future improvements. This research has important theoretical and practical implications for improving the accuracy and automation level of medical image segmentation.
Using Google Classroom as Assistive Technology in Universally Designed Classrooms
Authors: Sharpe Stephen , Young Gabrielle
Published: July 2023

This study focuses on the use of Google Classroom as assistive technology in inclusive classrooms. Findings were based on data collected through single-case study methodology in semi-structured formal and informal interviews with eight teachers and a focus group with six students at one junior high school in the province of Newfoundland and Labrador in Canada. This study is designed to better understand the benefits and challenges associated with the use of Google Classroom within the framework of universal design for learning. The findings showed that Google Classroom was perceived by both teachers and students as effective classroom technology in meeting the needs of each learner in the classroom.
Metaphors of Ed Tech, 2022. By Martin Weller. Athabasca University Press. 192 pages. ISBN 9781771993500
Authors: Lamb Brian
Published: July 2023

In Metaphors of Ed Tech, Martin Weller explores the field of learning technology in both the broadest and deepest senses. Weller chooses the application of metaphors as a method, and the resulting book reads more like an enjoyable set of ruminations than rigorous investigation. Weller has long employed metaphors and analogies on his blog, going back to 2006, and in this book he sets out to apply this “more playful aspect of thinking and writing about educational technology (ed tech)” across its practice and culture (p. 3).
Generative Adversarial Networks for Deep Learning in Healthcare: Architecture, Applications and Challenges
Authors: Garg Shankey , Singh Pradeep
Published: July 2023

Deep Learning is a new generation of artificial neural networks that have transformed our daily lives and has impacted several industries and scientific disciplines in recent years. Recent development in deep learning provides various significant methods to obtain end-to-end learning models from complex data. Generative Adversarial Networks give the idea of learning the deep representations without extensively interpreting the training data. The generative adversarial network involves the generative modeling approach that uses the deep learning approach. The chapter is broadly divided into the following sections as (1) Insights of deep learning & the generative adversarial networks, (2) GAN’s representative variants, training methods, architecture, and mathematical representation, and (3) Efficacy of GAN in different applications. This chapter will gain the recent work done in GAN and implement this technique in the different deep learning applications for healthcare. Here, we will also analyze some of the future perspectives and trends in the forthcoming time.
Threat Construction for Dynamic Enemy Status in a Platformer Game using Classical Genetic Algorithm
Authors: Harisa Ardiawan Bagus , Nugroho Setiawan , Umaroh Liya , Astuti Yani Parti
Published: July 2023

Digital game genres such as Action-Platformer is widely popular among buyers on a platform like Steam. The non-playable character enemies in the game are important in action games. Unfortunately, they usually have static attributes like health point, damage, and enemy movement. Using procedural content generation with a classical genetic algorithm, we drive the threat value of a platform to construct the enemy status resulting in more dynamic enemies. We use the threat value as an input parameter calculated from the enemies’ stats in every platform, such as total damage that the enemy might produce, the player’s health point, and the enemy’s movement speed. We conclude that using a classical genetic algorithm may produce dynamic enemy status through desired threat or danger set by the game designer as an input parameter. Moreover, the game designer may limit the generation with constraints.
Sessiz İstifa Ölçeği: Geçerlik Ve Güvenirlik Çalışması
Authors: SAVAŞ Buğra Çağatay , TURAN Murat
Published: July 2023

Bu araştırmanın amacı, üniversite öğrencilerinin sessiz istifa düzeylerinin ölçülmesini sağlayacak geçerli ve güvenilir bir ölçek geliştirmektir. Sessiz İstifa Ölçeği, iki ayrı araştırma grubundan elde edilen veriler analiz edilerek geliştirilmiştir. Ölçek karma model uygulanarak geliştirilmiştir. Madde havuzunun hazırlanmasında kapsam geçerliği incelenmiştir. Birinci grupta 317 öğrencinin cevapları değerlendirmeye alınmış ve uygulanan Açıklayıcı Faktör Analizi sonucunda ölçeğin, dört boyutlu bir yapıda olduğu, tamamı olumlu toplam 16 maddeden meydana geldiği tespit edilmiştir. Ölçeğin, açıkladığı varyans %76,66, Cronbach Alpha değeri ,94 olarak bulunmuştur. Ölçek, Bağlılıkta Azalma (4 madde), Motivasyonsuzluk (4 madde), Sosyalleşme (4 madde) ve Kendini Koruma (4 madde) alt boyutlarından oluşmaktadır. İkinci grupta 301 öğrenci yer almış ve bu gruptan elde edilen verilerle yapılan Doğrulayıcı Faktör Analizi sonucunda ölçeğin yapısına ait uyum indekslerinin kabul edilebilir değerlere sahip olduğu görülmüştür. Daha sonra ölçeğin madde ve güvenirlik analizleri yapılmış ve yeterli düzeyde oldukları görülmüştür. Sonuç olarak; Sessiz İstifa Ölçeğinin, üniversite öğrencilerinin sessiz istifa düzeylerini ölçmede geçerli ve güvenilir olarak kullanılabilecek bir ölçme aracı olduğu tespit edilmiştir.
Program Bimbingan Belajar Gratis Menggunakan Metode Bernyanyi dan Bermain
Authors: Arusman  , Aida Safitri  , Hanief Furqani  , Safrizal
Published: July 2023

Abstract

            Tutoring is guidance that aims to assist individuals in facing difficulties when studying. There are many teaching methods used by an educator to make children interested and enthusiastic in learning. These methods include singing and playing methods. The purpose of this study was to find out the benefits of free tutoring using the singing and playing method. This study uses a qualitative approach. In collecting data, this study used the observation method. Observations were made to find out the benefits of the singing and playing method when carried out in tutoring.

Keywords: Tutoring; Singing Method; Benefit Singing Method
PENGARUH UKURAN PERUSAHAAN, PROFITABILITAS, SOLVABILITAS, OPINI AUDIT DAN REPUTASI KAP TERHADAP AUDIT DELAY (STUDI EMPIRIS PADA PERUSAHAAN SUBSEKTOR PROPERTY DAN REAL ESTATE YANG TERCATAT DI BURSA EFEK INDONESIA TAHUN 2017-2019)
Authors: Mubaliroh Reni , Wijaya Rico , Olimsar Fredy
Published: July 2023

Penelitian ini bertujuan untuk membuktikan secara empiris pengaruh ukuran perusahaan, profitabilitas, solvabilitas, opini audit, dan reputasi KAP terhadap audit delay. Populasi dalam penelitian ini adalah perusahaan subsektor property dan real estate yang terdaftar di Bursa Efek Indonesia (BEI) dari tahun 2017-2019. Teknik yang digunakan dalam pengambilan sampel menggunakan purposive sampling, yaitu pengambilan sampel dengan kriteria tertentu di mana sampel sengaja dipilih untuk mewakili populasinya. Jumlah sampel yang digunakan dalam penelitian ini sebanyak 48 perusahaan dengan pengamatan selama tiga tahun sehingga terpilih 144 data pengamatan. Data yang digunakan adalah data sekunder berupa laporan keuangan tahunan perusahaan yang diperoleh dari Bursa Efek Indonesia (BEI). Teknik analisis data dalam penelitian ini adalah analisis statistik deskriptif, uji asumsi klasik, analisis regresi linier berganda, dan uji hipotesis. Software yang digunakan untuk olah data adalah SPSS versi 21. Hasil pengujian hipotesis menunjukkan bahwa secara simultan variabel profitabilitas, opini audit dan reputasi KAP berpengaruh secara signifikan terhadap audit delay, sedangkan variabel ukuran perusahaan dan solvabilitas tidak berpengaruh signifikan terhadap audit delay.
Prevalência de síndrome metabólica em pacientes pós-transplante renal
Authors: Ferreira Jordanna de Souza , Marcola Maria Clara Dourado , Rodrigues Daianna Lima da Mata
Published: July 2023

Introdução: O desenvolvimento da síndrome metabólica após o transplante renal (TxR) é evidenciado na literatura e se caracteriza por alterações que conferem a redução da função do enxerto. Objetivo: O objetivo deste trabalho é descrever a prevalência da síndrome metabólica e identificar variáveis que se associam à síndrome metabólica emreceptores de TxR tardio. Metodologia: Trata-se de um estudo transversal analítico realizado com pacientes receptores de TxR. Foram incluídos participantes com idade superior ou igual a 18 anos, receptores de TxR tardio em acompanhamento superior a 6 meses. A análise descritiva dos dados foi expressa por médias, desvio padrão, medianas e percentuais. A normalidade dos dados foi verificada pelo teste de Shapiro-Wilkao nível de 5% de significância. Aplicou-se o teste de comparação de médias para duas amostras independentes, teste t de Student. Foi utilizado o teste de correlação de Pearson para avaliar as possíveis relações existentes entre a variável tempo pós TxR com as outras variáveis de interesse. Resultados: Ao avaliar 43 pacientes com idade média de 50,9 ± 9,8 anos, notou-se que a síndrome metabólica esteve presente em 53,85% dos voluntários e que se associou ao peso prévio (p= 0,018), concentrações séricas de triglicerídeos (p= 0,001), menores médias de HDL (p= 0,053) e, também, foi verificada uma associação marginal com a circunferência da cintura (p= 0,051). A SM foi prevalente no período pós TxR. Ainda, as maiores médias de peso prévio ao TxR, de circunferência da cintura, de triglicerídeos e as menores médias de HDL se associaram à SM.
THE INFLUENCE OF HIJAB FASHION TRENDS ON CONSUMPTIVE BEHAVIOR OF ISLAMIC BANKING STUDENTS AT IAIN PEKALONGAN
Authors: Rosyada Fikri Amalia , Hendri Hermawan Adinugraha
Published: July 2023

Fashion is an important thing in the lives of teenagers and adults. Fashion is considered to provide a reflection of each person. The development of the hijab fashion trend is also developing among Muslims, especially among female students. The desire to follow the hijab fashion trend causes extravagant behaviour to support appearance. The purpose of this study is to analyze the effect of hijab fashion trends on the consumptive behaviour of Islamic Banking students at IAIN Pekalongan. The method used in this study was a qualitative method using a phenomenological approach and data collection using the methods of observation, interviews, and documentation. Meanwhile, the research subject was Islamic Banking student taken by purposive sampling method. The results of this study indicate that the hijab fashion trend has a significant influence on the consumptive behaviour of Islamic Banking students. The consumptive behaviour of female students is shown by the hijab worn on campus with various styles that are trends and a waste of buying hijab with the desire to fulfil their fashion style so that they can look attractive when leaving for campus.
Global and blow up solutions for a semilinear heat equation with variable reaction reaction on a general domain
Authors: Loayza Miguel , Castillo Ricardo
Published: July 2023

We are concerned with the existence of global and blow-up solutions for
the semilinear heat equation with variable exponent u t - Δ u = h ( t )
f ( u ) p ( x ) in Ω×(0 ,T) with zero Dirichlet boundary
condition and initial data in C 0 ( Ω ) . The scope of our analysis
encompasses both bounded and unbounded domains, with p ( x ) ∈ C ( Ω ) ,
0 < p - ≤ p ( x ) ≤ p + , h∈ C(0 ,∞), and
f∈ C[0 ,∞). Our findings have significant
implications, as they enhance the blow-up result discovered by Castillo
and Loayza in Comput. Math. App. 74(3), 351-359 (2017) when f(
u)= u.
The Effect of Behavioral Counseling Implementation with Modeling Techniques in Order to Reduce Students' Aggressive Behavior
Authors: Saputra I Nengah Budi , Dantes Nyoman , Suarni Ni Ketut
Published: July 2023

Experimental research on the effect of implementing behavioral counseling with modeling techniques in order to reduce student aggressive behavior has been widely carried out, but there has been no further study on the results of these studies to be summarized and reassessed so that they can strengthen the results of the research that has been done. This study aims to analyze and describe the effectiveness of the implementation of behavioral counseling with modeling techniques to reduce students' aggressive behavior. This research is library research with the research method used is meta-analysis. The subjects of this research are eleven articles from journals that have been published nationally. Data collection is done by document recording technique. The results of the article analysis by looking for the effect size based on the t-test value so that the effect size result is 2.148, which means it is included in the large category. Factors that influence student aggressive behavior consist of internal factors, namely behavioral patterns, biological factors and frustration, while external factors include poverty, environmental culture, situational, mass media. The results of this analysis strengthen the results of previous studies which state that the implementation of behavioral counseling with modeling techniques has an influence in reducing student aggressive behavior. Therefore this technique is very suitable to be used in order to reduce the aggressive behavior of students.
Classical Guidance Service Tools to Increase the Creativity of Junior High School Students
Authors: Mustofa Khilmi , Gading I Ketut , Widhiyanti Metra Putri Dewi Arum
Published: July 2023

The low creativity of students is due to the need for more guidance provided by teachers and counselors, so to overcome these problems, guidance service tools are needed to maximize the development of children's creativity. This study aims to produce a classical guidance service toolkit to increase the creativity of junior high school students. This research belongs to the development research developed using the 4-D development model. The 4-D development model comprises the define, design, development, and dissemination stages. The subjects involved in this study were three lecturers as experts and two guidance and counseling teachers as practitioners. Collecting data in the study was carried out using observation, interviews, and questionnaires. The instrument used is in the form of a student creativity questionnaire. The data obtained in the study were then analyzed using quantitative descriptive analysis techniques through the normality test, homogeneity test, and t-test. The results of data analysis in the study showed that the t-test score was 2.710, and sig. (2-tailed) was 0.009 <0.05, meaning H0 is rejected, and Ha is accepted. Based on these results, the classical guidance service tool effectively increases the creativity of junior high school students.
PREVALENCE AND ANTIMICROBIAL SUSCEPTIBILITY PATTERN OF PSEUDOMONAS AERUGINOSA ISOLATED FROM VARIOUS CLINICAL SAMPLES AT ELMC&H
Authors: Parveen Nighat , Khare Vineeta , Hassan Sarah , Asghar Syed Abid
Published: July 2023

To identify P. aeruginosa prevalence in different clinical samples along with to. Evaluate its antibiotic sensitivity method isolated from variety of clinical. Over the course of the six- month trial period, 1200 samples in total were analyzed. To identify and isolate P. aeruginosa, each of them underwent direct microscopy and culture. In this study 63 P. aeruginosa were isolated and identified out of 1200 clinical samples. Pus and urine were where the majority of P. aeruginosa were isolated from specimens. There found sensitivity to Piperacilin- tazobactam (10µg) 35% and Gentamycin (10µg) 38% respectively by kirbey-Bauer disc diffusion method. As an opportunistic organism with a high prevalence that is growing more common due to antimicrobial agent resistance, P. aeruginosa may pose a risk to health.
Efektivitas Anti Diabetes Ekstrak Etanol Rimpang Pacing (Costus Speciosus) terhadap Tingkah Laku Seksual Mencit Jantan (Mus Musculus) yang Diinduksi Aloksan
Authors: Rudini Mahmud , Wulansari Sri Mugi , Kuswanto Eko , Indarto Indarto
Published: July 2023

This study was conducted to determine the anti-diabetic effectiveness of the ethanol extract of pacing rhizome (Costus speciosus) on the sexual behavior of male mice (Mus musculus) induced by alloxan. This study used a completely randomized design (CRD) method consisting of 5 treatment groups with 5 replications each. Group KI (not given any treatment), group KII (given alloxan, without treatment), group KIII (without alloxan but given treatment), group PI (given alloxan and ethanol extract of pacing rhizome at a dose of 20 mg/30 gram BW/ days), PII group (given alloxan and ethanol extract of pacing rhizome at a dose of 30 mg/30 gram BW/day). Alloxan was given once and pacing rhizome extract was given every day for 14 days. Parameters observed were body weight of mice, blood glucose levels, sexual behavior of mice (number of approaches, number of rides, and number of mating). Observational data were analyzed by One-way ANOVA and followed by LSD at 5% level. AbstrakPenelitian ini dilakukan untuk untuk mengetahui efektivitas anti diabetes ekstrak etanol rimpang pacing (Costus speciosus) terhadap tingkah laku seksual mencit jantan (Mus musculus) yang diinduksi aloksan. Penelitian ini menggunakan metode Rancangan Acak Lengkap (RAL) yang terdiri dari 5 kelompok perlakuan dengan masing- masing 5 ulangan. Kelompok KI (tidak diberi perlakuan apapun), kelompok KII (diberi aloksan, tanpa diberi perlakuan), kelompok KIII (tanpa diberi aloksan tetapi diberi perlakuan), kelompok PI (diberi aloksan dan ekstrak etanol rimpang pacing dengan dosis 20 mg/30 gram BB/hari), kelompok PII (diberi aloksan dan ekstrak etanol rimpang pacing dengan dosis 30 mg/30 gram BB/hari). Aloksan diberikan satu kali dan ekstrak rimpang pacing diberikan setiap hari selama 14 hari. Parameter yang diamati adalah berat badan mencit, kadar glukosa darah, tingkah laku seksual mencit (jumlah pendekatan, jumlah penunggangan, dan jumlah kawin). Data hasil pengamatan dianalisis dengan One-way ANOVA dan dilanjutkan LSD pada taraf 5%)