bluuebunny/crossref_metadata_2025 huggingface dataset:
Beginning teachers in early childhood education: A critical discourse analysis of policies in Aotearoa New Zealand and the United States
Authors: Rubin Jessica Cira , Tily Susan
Published: April 2021

The early phases of teachers’ professional careers are multi-layered and informed by many factors, including teachers’ values, their own experiences in schools, and the nested contexts of their professional employment. While in teachers’ everyday lives government policies sometimes operate beneath the surface rather than overtly, these policies influence many teachers’ experiences, contributing significantly to what critical discourse analysis scholars call the ‘issue’ of teachers’ available subjectivities being influenced by prevailing ideologies as they are newly entering the profession. In this analysis, we activate critical discourse analysis in order to offer new understandings about policies and contexts associated with new teachers entering the profession. Our analysis is significant in its co-consideration of policies from contexts that we see as experiencing the influence of neoliberal ideologies in different ways. As critical discourse analysis is transdisciplinary, it also offers chances to transcend boundaries of politics and culture to inquire into social wrongs as we actually experience them in a world that is globally connected and globally influenced. The significance of this analysis, then, lies with the continued questioning we hope that it, and others like it, make possible.
Thirty-Day Results of the Novel CGuard-Covered Stent in Patients Undergoing Carotid Artery Stenting
Authors: Tigkiropoulos Konstantinos , Papoutsis Ioakeim , Abatzis-Papadopoulos Manolis , Kousidis Panagiotis , Mpismpos Dimitrios , Melas Nikolaos , Stavridis Kyriakos , Karamanos Dimitrios , Lazaridis Ioannis , Saratzis Nikolaos
Published: April 2021

Objective:

The aim of this study was to provide early-term evaluation, safety, and efficacy of the novel CGuard (Inspire MD, Tel Aviv, Israel) micromesh self-expanding stent with embolic protection system (EPS) during carotid artery stenting (CAS) procedure.

Materials and Methods:

All patients who underwent CAS with CGuard carotid stent system from January 2018 to September 2020 in a tertiary center were prospectively evaluated. Primary endpoints included technical success and perioperative neurological events (0–48 hours). Secondary endpoint was the rate of neurologic, cardiac events, and death (major adverse event or MAE) at 30 days. Patency of CGuard, peak systolic velocity (PSV), and end diastolic velocity (EDV) were evaluated at 30 days with duplex ultrasound.

Results:

A total of 103 patients underwent CAS procedure. Forty patients were symptomatic, and 63 patients were asymptomatic with stenosis greater than 70%. Technical success was 100%. Local anesthesia was applied in 94 patients (93%). Embolic protection devices were used in 6 patients (5.8%). Access site complications were 1.9%. Mean internal carotid artery stenosis diameter reduced from 79.47% to 14.68%. Two patients had transient ischemic attack (1.9%) and 1 patient experienced a cerebral hyperperfusion syndrome (CHS) perioperatively. External carotid artery (ECA) occlusion occurred in 1.9%. Four patients experienced jaw claudication (3.8%) postoperatively. Mean time of operation was 41 minutes. Mean duration of hospitalization was 3.1 days. The 30-day rate of MAE was 0%. CGuard patency was 100%, mean internal carotid PSV was reduced from 251.57 to 77.29 cm/s, and mean internal carotid EDV was reduced from 154.62 to 24.63 cm/s at 30 days.

Conclusion:

Our study shows that CGuard stent with EPS is an effective and safe device for treatment of carotid artery stenosis with acceptable low perioperative neurologic events, even with low embolic protection device usage. Larger multicenter and randomized studies are necessary to confirm its long-term efficacy.
Removal of Intravascular Foreign Bodies With a Simple Low-Cost Method: A Report of 5 Cases
Authors: Ribeiro Felipe Soares , Kumakura Harue , da Silva Erasmo Simão , Puech-Leão Pedro , De Luccia Nelson
Published: April 2021

Purpose:

Intravascular embolization of hemodialysis and central venous catheters is a rare but potentially serious complication. With the increasing use of catheters in medical practice, we are often faced with this type of complication. Novel, simple, and low-cost techniques are needed for foreign body extraction in order to reduce cardiovascular risks.

Case Report:

We describe the approach of 5 foreign body embolization cases. Case 1: a 57-year-old woman with end-stage renal failure with a complete fracture and migration of the distal extremity of a hemodialysis catheter. Case 2: a 55-year-old man with an accidental embolization of the distal portion of a hemodialysis catheter. Case 3: a 76-year-old woman with stage IV breast cancer and an accidental embolization of a central venous catheter guidewire. Cases 4 and 5: a 71-year-old woman and a 2-year-old boy with a port-a-cath embolization. All the patients underwent successful minimally invasive removal of the foreign bodies from the thoracic site using 5Fr pigtail catheters. Additional surgery was not required. No further complications, such as damage to the vascular wall, were noted.

Conclusion:

Our experience with the interlacing and traction pigtail show that it is a simple, practical, and low-cost technical alternative and its benefits should be widespread.
Gimme’ the Loop: Modifications to the Squid-Capture Technique for Laser-Fenestrated Thoracic Endografting
Authors: Mulorz Joscha , Knapsis Artis , Ertas Neslihan , Schelzig Hubert , Wagenhäuser Markus Udo
Published: April 2021

Purpose:

Laser-fenestrated thoracic endovascular aortic repair (LfTEVAR) in the aortic arch with covering of the left subclavian artery (LSA) orifice is challenging. To optimize fenestration, the so-called squid-capture technique has been introduced. We present here a modification to the technique that may help improve time-efficiency and safety.

Technique::

During the originally proposed squid-capture maneuver, the stent-graft is deployed in a preset snare wire loop, which is used to pull the stent graft toward the penetration device during in-situ fenestration. In preparation, the guidewire needs to be passed through the loop inside the aortic arch, which can be difficult and may predispose for embolic events. We propose here the creation of a “guidewire-through-snare-loop” configuration outside the body, which can then be reliably transferred into the aortic arch. The modified technique was successfully applied in a patient undergoing LfTEVAR for penetrating aortic ulcers.

Conclusion:

The proposed modification may help facilitate the squid-capture technique for LfTEVAR while saving time and resources. Given that LfTEVAR is becoming more frequently used, it is important to ensure technical success and safety of the procedure.
Simulation of polymer jet motion during melt blowing with phase field method
Authors: Hao Xibo , Zhao Zhiying , Wei Jing
Published: April 2021

In the past two decades, a number of models have been built to simulate the motion of polymer jet during melt blowing. Unfortunately, the complex interaction between polymer jet and air flow field has been rarely reported. In this work, a phase-field method was applied to simulate the coupling effects between polymer and air flow during melt blowing and the computed results were compared with the results of the model built through level-set method and experimental results. Velocity in the x direction, velocity in the y direction, whipping amplitude and diameter of polymer jet were discussed, respectively. It was found that the velocity predicted by the present model was higher than that predicted by the level-set method. However, both of them are close to the experimental value. The calculated final fiber diameter based on the phase-field method is much closer with the experimental value than that based on the level set method. Based on the model, the effect of polymer surface tension and slot angle on the polymer jet velocity were discussed.
Impact of COVID-19 on Dementia Caregivers and Factors Associated With their Anxiety Symptoms
Authors: Hwang Yeji , Connell LaShauna M. , Rajpara Anjali R. , Hodgson Nancy A.
Published: April 2021

Little is known about the family experience of caregiving for persons living with dementia (PLWD) at home during the COVID-19 pandemic. The purpose of this study was to examine the influence of COVID-19 on concerns of current family caregivers of PLWD. Study participants were recruited from the parent study, Healthy Patterns Clinical Trial (NCT03682185). Data was collected from 34 caregivers via semi-structured telephone interviews. Over 70% of the study participants reported worrying about spreading COVID-19 to the PLWD, 41% reported they had taken on additional caregiving duties for others in their family since COVID-19, and 62% reported one or more anxiety symptoms. Dementia caregivers who reported anxiety symptoms reported lower scores on functional independence of their care recipients compared to dementia caregivers who did not report anxiety symptoms ( p=0.036). Health care professionals should be alert to the concerns expressed by dementia caregivers for their well-being during this unprecedented pandemic.
Cold Plasma Treatment Promotes Full-thickness Healing of Skin Wounds in Murine Models
Authors: Jung Joon M. , Yoon Hae K. , Jung Chang J. , Jo Soo Y. , Hwang Sang G. , Lee Heun J. , Lee Woo J. , Chang Sung E. , Won Chong H.
Published: April 2021

Cold plasma can be beneficial for promoting skin wound healing and has a high potential of being effectively used in treating various wounds. Our aim was to verify the effect of cold plasma in accelerating wound healing and investigate its underlying mechanism in vitro and in vivo. For the in vivo experiments, 2 full-thickness dermal wounds were created in each mouse (n = 30). While one wound was exposed to 2 daily plasma treatments for 3 min, the other wound served as a control. The wounds were evaluated by imaging and histological analyses at 4, 7, and 11 days post the wound infliction process. Immunohistochemical studies were also performed at the same time points. In vitro proliferation and scratch assay using HaCaT keratinocytes and fibroblasts were performed. The expression levels of wound healing–related genes were analyzed by real-time polymerase chain reaction and western blot analysis. On day 7, the wound healing rates were 53.94% and 63.58% for the control group and the plasma-treated group, respectively. On day 11, these rates were 76.05% and 93.44% for the control and plasma-treated groups, respectively, and the difference between them was significant ( P = .039). Histological analysis demonstrated that plasma treatment promotes the formation of epidermal keratin and granular layers. Immunohistochemical studies also revealed that collagen 1, collagen 3, and alpha-smooth muscle actin appeared more abundantly in the plasma-treated group than in the control group. In vitro, the proliferation of keratinocytes was promoted by plasma exposure. Scratch assay showed that fibroblast exposure to plasma increased their migration. The expression levels of collagen 1, collagen 3, and alpha-smooth muscle actin were elevated upon plasma treatment. In conclusion, cold plasma can accelerate skin wound healing and is well tolerated.
Substance P, a Neuropeptide, Promotes Wound Healing via Neurokinin-1 Receptor
Authors: Kant Vinay , Mahapatra Puspendra S. , Gupta Vijayta , Bag Sadhan , Gopalakrishnan Anu , Kumar Dhirendra , Kumar Dinesh
Published: April 2021

Substance P (SP), an endogenous neuropeptide, mediates intracellular signaling, mainly through a tachykinin receptor. The tachykinin receptors family consists of neurokinin-1 (NK-1), neurokinin-2 (NK-2), and neurokinin-3 receptors. Our previous studies on SP have shown its wound healing potentials. But the exact mechanism of wound healing by SP is not exactly known. In view of this, the present study was aimed at evaluating the in vitro wound healing effect of SP alone and in the presence of NK-1, NK-2, and both receptor antagonists. Scratch assay, transwell assay, and tumor growth factor-beta 1 (TGF-β1) assay were performed on buffalo fetal fibroblast culture. The cotreatment of fibroblast cultures with SP alone during the 24 h caused the significant proliferation and migrations of cells in both horizontal and vertical directions. The SP in the presence of spantide II (NK-1 antagonist) failed to stimulate this migration. The treatment of cells with SP in the presence of NK-2 antagonist treatment also showed a significant reduction of migration of cells with respect to SP treatment alone. The SP in the presence of both NK-1 and NK-2 antagonists failed to stimulate the horizontal migration of cells and most of the ineffectiveness of SP was observed in this combination. The TGF-β1 levels were significantly higher in the supernatants of cells that were exposed to SP alone. All other treatments have significantly lower TGF-β1 levels than SP alone treatment. It is concluded that different actions on fibroblast cells by SP were mainly mediated through the NK-1 receptor.
The Effects of Antimicrobial Resistance and the Compatibility of Initial Antibiotic Treatment on Clinical Outcomes in Patients With Diabetic Foot Infection
Authors: Saltoglu Nese , Surme Serkan , Ezirmik Elif , Kadanali Ayten , Kurt Ahmet Furkan , Sahin Ozdemir Meryem , Ak Oznur , Altay Fatma Aybala , Acar Ali , Cakar Zeynep Sule , Tulek Necla , Kinikli Sami ,   KLİMİK Society, Diabetic Foot Study Group
Published: April 2021

We aimed to determine pathogen microorganisms, their antimicrobial resistance patterns, and the effect of initial treatment on clinical outcomes in patients with diabetic foot infection (DFI). Patients with DFI from 5 centers were included in this multicenter observational prospective study between June 2018 and June 2019. Multivariate analysis was performed for the predictors of reinfection/death and major amputation. A total of 284 patients were recorded. Of whom, 193 (68%) were male and the median age was 59.9 ± 11.3 years. One hundred nineteen (41.9%) patients had amputations, as the minor (n = 83, 29.2%) or major (n = 36, 12.7%). The mortality rate was 1.7% with 4 deaths. A total of 247 microorganisms were isolated from 200 patients. The most common microorganisms were Staphylococcus aureus (n = 36, 14.6%) and Escherichia coli (n = 32, 13.0%). Methicillin resistance rates were 19.4% and 69.6% in S aureus and coagulase-negative Staphylococcus spp., respectively. Multidrug-resistant Pseudomonas aeruginosa was detected in 4 of 22 (18.2%) isolates. Extended-spectrum beta-lactamase-producing Gram-negative bacteria were detected in 20 (38.5%) isolates of E coli (14 of 32) and Klebsiella spp. (6 of 20). When the initial treatment was inappropriate, Klebsiella spp. related reinfection within 1 to 3 months was observed more frequently. Polymicrobial infection ( p = .043) and vancomycin treatment ( p = .007) were independent predictors of reinfection/death. Multivariate analysis revealed vascular insufficiency ( p = .004), hospital readmission ( p = .009), C-reactive protein > 130 mg/dL ( p = .007), and receiving carbapenems ( p = .005) as independent predictors of major amputation. Our results justify the importance of using appropriate narrow-spectrum empirical antimicrobials because higher rates of reinfection and major amputation were found even in the use of broad-spectrum antimicrobials.
Translation of the Pediatric Nausea Assessment Tool (PeNAT) Into Spanish and Evaluating Understandability Among Spanish-Speaking Hispanic American Children and Adolescents Receiving Chemotherapy
Authors: Garcia Frausto Erica , Sivananthan Araby , Golden Carla , Szuminski Molly , Prado Luz N Pérez , Lopez Mercedes Paloma , Diaz Virginia , Nieto Dominica , Plenert Erin , Langevin Anne-Marie , Dupuis L. Lee
Published: April 2021

Introduction:

We aimed to create a Spanish-language version of the Pediatric Nausea Assessment Tool (PeNAT) and examine its understandability among Spanish-speaking, Hispanic American children.

Methods:

Translation: Forward and backward translations of the PeNAT documents were performed and verified by a bilingual panel. Four monolingual, Spanish-speaking dyads (child/parent) and four bilingual dyads piloted the Spanish-language PeNAT documents. Four additional bilingual dyads read both versions and completed the PeNAT using their preferred version. These were reviewed for errors due to misunderstanding.

Understandability:

Children aged 4–18 years about to receive chemotherapy who spoke Spanish at home and were without impairments precluding PeNAT use were eligible. Participants used the Spanish-language PeNAT during a chemotherapy block. Parents gave feedback on the PeNAT documents. Recruitment continued until 10 consecutive participants offered no substantive suggestions for revision.

Results:

Translation: All child/parent dyads completed the PeNAT without errors attributable to misunderstanding. The Spanish-language PeNAT was preferred by three of four bilingual dyads. Understandability: Ten cancer patients (mean age: 10.6 years) used the Spanish-language PeNAT. All parents felt their child understood the PeNAT; none felt the documents were hard or very hard to use.

Conclusion:

The Spanish-language PeNAT was understood by Spanish-speaking Hispanic American children. Further psychometric testing is warranted.
Effectiveness of Tendon and Nerve Gliding Exercises in the Treatment of Patients With Mild Idiopathic Carpal Tunnel Syndrome: A Randomized Controlled Trial
Authors: Abdolrazaghi Hossein Ali , Khansari Mahmoud , Mirshahi Maryam , Ahmadi Pishkuhi Mahin
Published: April 2021

Background

There is limited evidence regarding the efficacy of different treatment options in patients with carpal tunnel syndrome (CTS). This study aimed at assessing the effectiveness of nerve and tendon gliding exercises in the treatment of patients with mild CTS.

Methods

The current prospective, randomized trial with pretest-posttest design was conducted on 80 patients with mild CTS randomly assigned to 2 groups. The treatment group was instructed to perform gliding exercises in addition to the wrist splint use. The control group only used the wrist splint. All the patients were instructed to use the splint at night and during the day if required. Patients were evaluated in terms of clinical parameters (ie, grip and pinch strength). The severity of symptoms and functional status was also determined using the Boston Carpal Tunnel Syndrome Questionnaire. The subjects were followed up for 6 weeks.

Results

There were no significant differences in all parameters between groups. The pretest-posttest analysis showed a statistically significant improvement in subjective and objective parameters in the treatment group. However, in the control group, only a significant improvement was observed in grip strength. Wrist splint use led to a significant change in the severity of symptoms only over the second week.

Conclusions

Both gliding exercise and wrist splint groups showed some improvement in the severity of symptoms and functional status scores. However, the gliding exercises did not offer additional benefit compared with wrist splint alone.
e-ASPECTS software improves interobserver agreement and accuracy of interpretation of aspects score
Authors: Brinjikji Waleed , Abbasi Mehdi , Arnold Catherine , Benson John C , Braksick Sherry A , Campeau Norbert , Carr Carrie M , Cogswell Petrice M , Klaas James P , Liebo Greta B , Little Jason T , Luetmer Patrick H , Messina Steven A , Nagelschneider Alex A , Schwartz Kara M , Wood Christopher P , Nasr Deena M , Kallmes David F
Published: April 2021

Introduction

There is increased interest in the use of artificial intelligence-based (AI) software packages in the evaluation of neuroimaging studies for acute ischemic stroke. We studied whether, compared to standard image interpretation without AI, Brainomix e-ASPECTS software improved interobserver agreement and accuracy in detecting ASPECTS regions affected in anterior circulation LVO.

Methods

We included 60 consecutive patients with anterior circulation LVO who had TICI 3 revascularization within 60 minutes of their baseline CT. A total of 16 readers, including senior neuroradiologists, junior neuroradiologists and vascular neurologists participated. Readers interpreted CT scans on independent workstations and assessed final ASPECTS and evaluated whether each individual ASPECTS region was affected. Two months later, readers again evaluated the CT scans, but with assistance of e-ASPECTS software. We assessed interclass correlation coefficient for total ASPECTS and interobserver agreement with Fleiss’ Kappa for each ASPECTS region with and without assistance of the e-ASPECTS. We also assessed accuracy for the readers with and without e-ASPECTS assistance. In our assessment of accuracy, ground truth was the 24 hour CT in this cohort of patients who had prompt and complete revascularization.

Results

Interclass correlation coefficient for total ASPECTS without e-ASPECTS assistance was 0.395, indicating fair agreement compared, to 0.574 with e-ASPECTS assistance, indicating good agreement (P < 0.01). There was significant improvement in inter-rater agreement with e-ASPECTS assistance for each individual region with the exception of M6 and caudate. The e-ASPECTS software had higher accuracy than the overall cohort of readers (with and without e-ASPECTS assistance) for every region except the caudate.

Conclusions

Use of Brainomix e-ASPECTS software resulted in significant improvements in inter-rater agreement and accuracy of ASPECTS score evaluation in a large group of neuroradiologists and neurologists. e-ASPECTS software was more predictive of final infarct/ASPECTS than the overall group interpreting the CT scans with and without e-ASPECTS assistance.
Parallel collaborative planning for the coupled system of underground heavy-load robot
Authors: Lixia Fang , Wang Tong , Shen Yang , Wang Pengjiang , Wu Miao
Published: April 2021

At present, designing and planning of robots are mainly based on path planning. This mode cannot meet requirements of real-time and precise planning for robots, especially under complex working conditions. Therefore, a parallel collaborative planning strategy is proposed in this paper, which parallel collaborates optimal task allocation planning and optimal local path planning. That is, according to real-time dynamic working environment of robots, the dynamic optimal task allocation planning strategy for coupled system of robot in low coupling state is adopted, to improve real-time working efficiency of underground heavy-load robot. Meanwhile, the parallel elite particle swarm optimization algorithm is adopted to improve accuracy of path tracking and controlling. Finally, the two planning strategies are collaborated parallel to realize intelligent and efficient planning of whole complex coupled system for underground heavy-load robot. The simulation and experiment results show that the parallel collaborative planning algorithm proposed in this paper has perfect controlling effects: Total flow of overall system is saved by 11.03 L, execution time saved by 16.8 s and implementation efficiency has been improved by 10 times. Therefore, the parallel collaborative planning strategy proposed in this paper can not only meet requirements of high efficiency and precision of intelligent robot under complex working conditions, but also greatly improve real-time working effectiveness and robustness of robots, so as to provide a reference for dynamic planning of complex intelligent engineering machinery, and also supply design basis for development of multi-robot collaborative system.
Optimization of factors for the prevention of spinal cord ischemia in thoracic endovascular aortic repair
Authors: Sulzinski Michelle C , Rossi Matthew John , Alfawaz Abdullah A , Reynolds Kyle B , Maloni Krystal C , Kiguchi Misaki M , Dearing Joshua A , Abramowitz Steven D , Vallabhaneni Raghuveer , Woo Edward Y , Fatima Javairiah
Published: April 2021

Objectives

Spinal cord ischemia following thoracic endovascular aortic repair (TEVAR) is a devastating complication. This study seeks to demonstrate how a standardized protocol to prevent spinal cord ischemia affects incidence in patients undergoing TEVAR.

Methods

Using CPT codes 33880 and 33881, all TEVAR procedures performed at a single tertiary care center from January 2017 to December 2018 were examined. Patients who had concomitant ascending aortic repairs or a TEVAR for traumatic indications were excluded from analysis, leaving 130 TEVAR procedures. Comorbid conditions, procedural characteristics, extent of coverage, peri-procedural management strategies, and post-operative outcomes were collected and analyzed retrospectively.

Results

One hundred thirty patients undergoing TEVAR were examined for four perioperative variables: postoperative hemoglobin greater than 10 g/dL, subclavian revascularization, preoperative spinal drain placement, and somatosensory evoked potential monitoring (SSEP). All conditions were met in 46.2% (60/130) of procedures; 37.8% (28/74) in emergent/urgent cases and 61.5% (32/52) in elective cases. Of patients who required subclavian coverage, 87.1% (54/62) underwent subclavian revascularization; 70.8% (92/130) of patients received spinal drains preoperatively; 68.5% (89/130) of patients had SSEP monitoring; 73.8% (93/130) of patients obtained a postoperative hemoglobin of >10 g/dL. Out of all patients, two (1.5%) developed spinal cord ischemia.

Conclusion

Incidence of spinal cord ischemia in our cohort was low at 1.5% (2/130). Individual and bundled interventions for the prevention of spinal cord ischemia were unable to demonstrate a statistically significant effect given the low rate. Nonetheless, we advocate for a proactive approach for the prevention of spinal cord ischemia given our experience in this complex population.
Pharmacological modulation of brain activation to non-noxious stimulation in a cynomolgus macaque model of peripheral nerve injury
Authors: Hama Aldric , Yano Mizuho , Sotogawa Wakana , Fujii Rintaro , Awaga Yuji , Natsume Takahiro , Hayashi Ikuo , Takamatsu Hiroyuki
Published: April 2021

In vivo neuroimaging could be utilized as a noninvasive tool for elaborating the CNS mechanism of chronic pain and for elaborating mechanisms of potential analgesic therapeutics. A model of unilateral peripheral neuropathy was developed in the cynomolgus macaque, a species that is phylogenetically close to humans. Nerve entrapment was induced by placing a 4 mm length of polyvinyl cuff around the left common sciatic nerve. Prior to nerve injury, stimulation of the foot with a range of non-noxious von Frey filaments (1, 4, 8, 15, and 26 g) did not evoke brain activation as observed with functional magnetic resonance imaging (fMRI). Two weeks after injury, stimulation of the ipsilateral foot with non-noxious filaments activated the contralateral insula/secondary somatosensory cortex (Ins/SII) and anterior cingulate cortex (ACC). By contrast, no activation was observed with stimulation of the contralateral foot. Robust bilateral activation of thalamus was observed three to five weeks after nerve injury. Treatment with the clinical analgesic pregabalin reduced evoked activation of Ins/SII, thalamus and ACC whereas treatment with the NK1 receptor antagonist aprepitant reduced activation of the ipsilateral (left) thalamus. Twelve to 13 weeks after nerve injury, treatment with pregabalin reduced evoked activation of all regions of interest (ROI). By contrast, brain activation persisted in most ROI, except the ACC, following aprepitant treatment. Activation of the contralateral Ins/SII and bilateral thalamus was observed six months after nerve injury and pregabalin treatment suppressed activation of these nuclei. The current findings demonstrated persistent changes in CNS neurons following nerve injury as suggested by activation with non-painful mechanical stimulation. Furthermore, it was possible to functionally distinguish between a clinically efficacious analgesic drug, pregabalin, from a drug that has not demonstrated significant clinical analgesic efficacy, aprepitant. In vivo neuroimaging in the current nonhuman model could enhance translatability.
GP advocacy in supporting migrant access to NHS healthcare
Authors: Boulton Marina , Verma Anish , Metcalfe Neil H.
Published: April 2021

Recent policy reform within the NHS poses significant challenges to accessing healthcare for migrants. This follows the introduction of upfront charging in healthcare services for those not ordinarily resident in the UK. The eligibility for free NHS care is currently determined by an individual’s immigration status. This has denied treatment to many of those who lack the relevant financial means, particularly the migrant population. Migrants are recognised to have various complex health needs and to experience a number of difficulties in accessing healthcare, from language barriers to navigating through an unfamiliar healthcare system. There is also concern that migrants may be deterred from engaging with healthcare services after certain policies have mandated NHS trusts to share confidential patient information with the Home Office. Restrictive NHS policies are likely to exacerbate existing barriers for access to healthcare, which could have a devastating impact on migrant health. Similarly, this may inadvertently widen health inequalities and increase the disease burden in society. GPs hold a valuable role, in which they can advocate on behalf of their patients. Advocacy support can empower migrants in making informed decisions and help to protect their rights in accessing healthcare. This article provides a concise overview of the wider impact of restrictive policies within the NHS, and supports GPs in advocating on behalf of migrants to improve their access to healthcare.
Efficacy and side effects of immune checkpoint inhibitors in the treatment of colorectal cancer
Authors: Manz Salomon M. , Losa Marco , Fritsch Ralph , Scharl Michael
Published: April 2021

Colorectal cancers (CRCs) remain one of the most common and challenging neoplasia in the Western world. The response rate of immunotherapeutic treatment approaches in a subset of advanced CRCs is remarkable and has sustainably changed treatment regimens. Unfortunately, currently available immunotherapeutics only displayed significant antitumoral activity – in terms of progression free survival (PFS) and objective response rate (ORR) – in microsatellite instability-high (MSI-H)/DNA mismatch repair deficient (dMMR) CRCs. Subsequently, these remarkable results had led to the US Food and Drug Administration’s approval of both immune checkpoint inhibitors (ICIs) pembrolizumab and nivolumab in the treatment of advanced MSI-H/dMMR CRCs. However, in microsatellite stable (MSS)/DNA mismatch repair proficient (pMMR) CRCs, ICIs have clearly failed to meet their expectations and are therefore not considered effective. As the vast majority of CRCs display a molecular MSS/pMMR profile, current treatment approaches endeavor to improve tumor immunogenicity that consecutively leads to increased proinflammatory cytokine levels as well as tumor infiltrating T-cells, which in turn may be targeted by various immunotherapeutic agents. Therefore, ongoing studies are investigating novel synergistic therapy modalities and approaches to overcome a “cold” to “hot” tumor conversion in MSS/pMMR CRCs. In this review, we summarize the efficacy and possible immune-related adverse events as well as novel therapeutic approaches of ICIs in the treatment of MSI-H/dMMR and MSS/pMMR CRCs.
New pathway ameliorating ulcerative colitis: focus on Roseburia intestinalis and the gut–brain axis
Authors: Xu Fenghua , Cheng Yi , Ruan Guangcong , Fan Liqin , Tian Yuting , Xiao Zhifeng , Chen Dongfeng , Wei Yanling
Published: April 2021

Background:

The community of gut microbes is a key factor controlling the intestinal barrier that communicates with the nervous system through the gut–brain axis. Based on our clinical data showing that populations of Roseburia intestinalis are dramatically decreased in the gut of patients with ulcerative colitis, we studied the efficacy of a strain belonging to this species in the context of colitis and stress using animal models.

Methods:

Dextran sulfate sodium was used to induce colitis in rats, which then underwent an enema with R. intestinalis as a treatment. The disease activity index, fecal changes and body weight of rats were recorded to evaluate colitis, while histological and immunohistochemical analyses were carried out to examine colon function, and 16S rRNA sequencing was performed to evaluate the gut microbiota change. Behavioral assays and immunohistochemical staining of brain were performed to assess the effect of R. intestinalis on the gut–brain axis.

Results:

Colitis-related symptoms in rats were significantly relieved after R. intestinalis enema, and the stool traits and colon length of rats were significantly recovered after treatment. The gut epithelial integrity and intestinal barrier were restored in treated rats, as evidenced by the higher expression of Zo-1 in colon tissues, accompanied by the restoration of gut microbiota. Meanwhile, depressive-like behaviors of rats were reduced after treatment, and laboratory experiments on neuronal cells also showed that IL-6, IL-7 and 5-HT were downregulated by R. intestinalis treatment in both serum and brain tissue, while Iba-1 expression was reduced in treated rats.

Conclusions:

The administration of R. intestinalis contributes to restoration of the gut microbiota, promoting colon repair and the recovery of gastrointestinal function. These alterations are accompanied by the relief of depressive-like behaviors through a process modulated by the neuronal network and the regulation of inflammation by the gut–brain axis.
Two Decades of Research in Artificial Pancreas: Insights from a Bibliometric Analysis
Authors: León-Vargas Fabian , Arango Oviedo Jineth Andrea , Luna Wandurraga Héctor Javier
Published: April 2021

Background:

Artificial pancreas is a well-known research topic devoted to achieving better glycemic outcomes that has been attracting increasing attention over the years. However, there is a lack of systematic, chronological, and synthesizing studies that show the background of the knowledge generation in this field. This study implements a bibliometric analysis to recognize the main documents, type of publications, research categories, countries, keywords, organizations, and authors related to this topic.

Methods:

Web of Science core collection database was accessed from 2000 to 2020 in order to select high-quality scientific documents based on a specific search query. Bibexcel, MS Excel, Power BI, R-Studio, VOSviewer, and CorText software were used for a descriptive and network analysis based on the local database obtained. Bibliometric parameters as the h-index, frequencies, co-authorship and co-ocurrences were computed.

Results:

A total of 756 documents were included that show a growing scientific production on this topic with an increasing contribution from engineering. Outstanding authors, organizations, and countries were identified. An analysis of trends in research was conducted according to the scientific categories of the Web of Science database to identify the main research interests of the last 2 decades and the emerging areas with greater prominence in the coming years. A keyword network analysis allowed to identify the main stages in the development of the AP research over time.

Conclusions:

Results reveal a comprehensive background of the knowledge generation for the AP topic during the last 2 decades, which has been strengthened with international collaborations and a remarkable interdisciplinarity between endocrinology and engineering, giving rise to a growing number of research areas over time, where computer science and medical informatics stand out as the main emerging research areas.
Japanese Translation and Validation of the Environmental Assessment Tool–Higher Care
Authors: Brennan Sumiyo , Doan Therese , Bennett Kirsty , Hashimoto Yumiko , Fleming Richard
Published: April 2021

Objective:

The purpose of this study was to translate the Environmental Assessment Tool–Higher Care (EAT-HC) into Japanese and validate its use in small-scale group living facilities in Japan.

Background:

Environment of a facility is shown to improve its residents’ quality of life (QOL). Japan’s “welfare-based nursing homes for the elderly” are gradually shifting to a small-scale group living concept called group care units (GCUs). However, there is no appropriate environmental tool available for evaluating GCUs. The application of valid environmental assessment tools brings about a better understanding of the nature of good environments and the relationship between environments and outcomes for residents living with dementia.

Methods:

The study had a mixed method design conducted in several steps, covering translation and adaptation. The translation phase involved (1) forward translation and (2) backward translation. The adaptation phase involved (3) content validity and homogeneity reliability and (4) concurrent validity and interrater reliability.

Results:

71 Items (92%) met the acceptable level of content validity (item-content validity index [CVI] > .79) and had good scale-CVI of .88. Concurrent validity was confirmed between .65 and .78 ( p < .001). For reliability test, the internal consistency of six subscales was between .88 and .98. Overall interobserver agreement was 90.3%. Intraclass correlation coefficients were .80–.98 ( p < .001), and homogeneity reliability coefficient for all items was >.76 ( p < .01).

Conclusions:

Validation of the EAT-HC-Japanese Version (EAT-HC-JV) was confirmed as an appropriate tool for environmental assessment to enhance the QOL in Japan’s GCUs. For future study, we plan to modify the EAT-HC-JV to adapt to Japanese cultural aspects in order to increase its usability in Japan.
Ideal Donor Site for Osteochondral Autografting of the Distal Femur Using Radius of Curvature: A 3-Dimensional High-Resolution Scanner Comparison
Authors: Massey Patrick A. , Lowery Michael T. , Houk Garrett , McClary Kaylan N. , Barton R. Shane , Solitro Giovanni F.
Published: April 2021

Objective

To compare radius of curvature (RoC) of distal femur osteochondral autograft transfer (OAT) donor sites from the intercondylar notch and trochlear ridge with recipient sites on the distal and posterior condyles and evaluate differences between recipient sites.

Design

Nineteen cadaveric femurs were scanned with a 3-dimensional high-resolution sensor. Donor regions included the lateral (LTR) and medial trochlear ridges (MTR), and the lateral (LICN) and medial intercondylar notch (MICN). Recipient regions analyzed were the distal medial (DMFC), posterior medial (PMFC), distal lateral (DLFC), and posterior lateral femur condyle (PLFC). Six-millimeter OAT grafts were simulated, and average RoC of all regions was compared using an analysis of variance. Post hoc testing was performed using Fisher’s least significant difference.

Results

We found no significant differences in RoC of the LICN compared with all 4 recipient sites ( P = 0.19, 0.97, 0.11, and 0.75 for DLFC, PLFC, DMFC, and PMFC, respectively) or the LTR and MTR to the posterior condyles (LTR vs. PLFC and PMFC; P = 0.72, 0.47, MTR vs. PLFC and PMFC P = 0.39, 0.22, respectively). Significant differences were found for RoC of the MICN compared with each recipient site ( P < 0.001) and between distal and posterior femoral condyles (DLFC vs. PLFC, P = 0.016; DMFC vs. PMFC, P = 0.023).

Conclusion

The LICN is the ideal donor option for all recipient sites on the femoral condyles with respect to RoC of 6-mm OAT plugs. The MTR and LTR were acceptable donor sources for the posterior condyles, while the MICN was a poor match for all recipient sites. Additionally, the distal femur condyle and posterior femur condyle have different RoCs.
Identification of Key Genes and Pathways in Osteoarthritis via Bioinformatic Tools: An Updated Analysis
Authors: Zhang Yijian , Zhu Tianfeng , He Fan , Chen Angela Carley , Yang Huilin , Zhu Xuesong
Published: April 2021

Objective

Osteoarthritis (OA) is a severe and common degenerative disease; however, the exact pathology of OA is undefined. Our study is designed to investigate the underlying molecular mechanism of OA with bioinformatic tools.

Design

Three updated GEO datasets: GSE55235, GSE55457, and GSE82107 were selected for data analyzing. R software was utilized to screen and confirm the candidate differentially expressed genes in the development of OA. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes pathway were performed to identify the enriched GO terms and signaling pathways. Protein and protein interaction (PPI) models were built to observe the connected relationship among each potential protein.

Results

A total of 113 upregulated genes and 161 downregulated genes were found by integrating 3 datasets. GO enrichment indicated that cell differentiation, cellular response to starvation, and negative regulation of phosphorylation were important biological processes. KEGG enrichment indicated that FoxO, IL-17 signaling pathways, and osteoclast differentiation mainly participated in the progression of OA. Combining the molecular function and PPI results, ubiquitylation was identified as a pivotal bioactive reaction involved in OA.

Conclusion

Our study provided updated candidate genes and pathways of OA, which may benefit further research and treatment for OA.
EZH2 is involved in psoriasis progression by impairing miR-125a-5p inhibition of SFMBT1 and leading to inhibition of the TGFβ/SMAD pathway
Authors: Qu Shengming , Liu Zhe , Wang Bing
Published: April 2021

Aims:

In this study, we aimed to decipher the impact of enhancer of zeste homolog 2 (EZH2) in psoriasis as well as the underlying mechanism.

Methods:

A mouse model of psoriasis was developed by means of imiquimod induction, with the expression of EZH2, microRNA-125a-5p (miR-125a-5p), and SFMBT1 determined. The role of EZH2, miR-125a-5p, and SFMBT1 in malignant phenotypes of HaCaT cells and the development of psoriasis in vivo was subsequently investigated through gain- and loss-of-function experiments. Chromatin immunoprecipitation assay and dual-luciferase reporter assay were conducted to explore the relationship between EZH2 or SFMBT1 and miR-125a-5p. Finally, the effects of EZH2 and miR-125a-5p on the transforming growth factor β (TGFβ)/SMAD pathway were analyzed.

Results:

Overexpressed SFMBT1 and EZH2 was detected while miR-125a-5p were downregulated in psoriasis tissues and human keratinocyte (HaCaT) cells. EZH2 increased the levels of IL-17A-induced cytokines and promoted the malignant phenotypes of HaCaT cells. Functionally, EZH2 reduced miR-125a-5p expression while miR-125a-5p targeted SFMBT1 to activate the TGFβ/SMAD pathway in vitro. Knockdown of EZH2 or up-regulation of miR-125a-5p inhibited cell proliferation and the levels of IL-17A-induced cytokines, but increased the expression of TGFβ1 and the extent of smad2 and smad3 phosphorylation in HaCaT cells. Notably, EZH2 contributed to the development of psoriasis in vivo by inhibiting the TGFβ/SMAD pathway via impairment of miR-125a-5p-mediated SFMBT1 inhibition.

Conclusion:

Taken together, the results of the current study highlight the ability of EZH2 to potentially inactivate the TGFβ/SMAD pathway via upregulation of miR-125a-5p-dependent SFMBT1during the progression of psoriatic lesions.
Climate-driven losses to knowledge systems and cultural heritage: A literature review exploring the impacts on Indigenous and local cultures
Authors: Pearson Jasmine , Jackson Guy , McNamara Karen E
Published: April 2021

Anthropogenic climate change is leading to widespread losses around the world. While the focus of research over the last decade has largely been on economic or tangible losses, researchers have begun to shift their focus to understanding the non-economic or intangible dimensions of loss more deeply. Loss of life, biodiversity and social cohesion are some of the losses that are beginning to be explored, along with Indigenous and local knowledge (ILK) and cultural heritage. These latter two form the basis of this systematic review of 100 studies to take stock of what we know about climate-driven losses to ILK and cultural heritage, how such losses manifest and how they are overcome, revealing gaps in our knowledge and carving a path for future research.
The Relations Between Motivation, Strategy Use, Frequency, and Proficiency in Foreign Language Reading: An Investigation With University English Language Learners in China
Authors: Han Feifei
Published: April 2021

This study explores the structure of motivation in foreign language (FL) reading among 186 university English language learners (ELLs) in China, and investigated the relations between motivation, strategy use, frequency, and proficiency in FL reading. The data were collected from three questionnaires and the reading section of a mock College English Test (Band 4). The data were analyzed using exploratory factor analysis (EFA), correlation, hierarchical cluster analysis, and t tests. The EFA generated three scales, one for intrinsic motivation (i.e., the Efficacy and Engagement scale) and two for extrinsic motivation (i.e., the Utility Value scale and the Academic Value scale). The correlation analyses showed that only the Efficacy and Engagement scale was significantly correlated with reading proficiency. The cluster analysis identified two groups of students, who differed in the three motivation scales as their motivational profiles. Based on the motivational profiles, differences on strategy use, frequency, and proficiency in English were also observed.
Linguistic Diversity Index: A Scientometric Measure to Enhance the Relevance of Small and Minority Group Languages
Authors: Linkov Václav , O’Doherty Kieran , Choi Eunsoo , Han Gyuseog
Published: April 2021

Current scientometric indexes do not encourage the linguistic diversity of sources cited in academic texts and researchers are not motivated to cite texts written in smaller languages. This diminishes the cultural diversity of the sources cited and limits the representation of small and indigenous cultures. This text proposes a scientometric measure designed to encourage the linguistic diversity of sources cited in articles, books, and papers. The Linguistic Diversity Index is based on two stipulations: (a) the more linguistically diverse the sources, the higher the score, and (b) the rarer the languages cited, the higher the score. If such a metric were used for the evaluation of social science and humanities journals, it would encourage the publication of papers that cite ideas from rarely represented cultural groups such as indigenous nations, ethnic groups from small countries, and other linguistic groups that have been omitted from mainstream scientific discourse. This might help to produce new research, which would help to improve the situation for these groups and create an epistemology that is more just to small cultural groups.
#Gramming Gender: The Cognizance of Equality on Instagram Accounts of Prominent NCAA Athletic Departments
Authors: Johnson Rich G. , Romney Miles , Burroughs Benjamin
Published: April 2021

Under the federally mandated Title IX, NCAA athletic departments are directed to offer balanced promotional and informational coverage between men’s and women’s sports. This study examines how gender is represented in photographs on the Instagram accounts of prominent NCAA athletic departments. Findings indicate mixed results: female athletes, when showcased, receive similar promotional efforts to their male peers; their athleticism is highlighted; and fan engagement metrics are as high as male sports. However, female athletic achievements are overwhelmingly underrepresented, suggesting equality is still deficient.