bluuebunny/crossref_metadata_2025 huggingface dataset:
Ekonomia rozwoju wobec problemów nędzy i nierówności społecznych na świecie
Authors: Piasecki Ryszard
Published: February 2023

Development economics became a separate discipline in economic science in the 50s but only in
the 60s and mid-70s can one note a bigger interest in those issues. Gradually, there has appeared
an extensive literature concerning economic development. In the 80s it turned out, however, that despite
some successes, the economic development of the majority of mid- and less developed countries was
less satisfactory than expected. During most of the 80s and 90s the so-called Washington consensus
dominated theory and practice of economic development. This notion covered the whole range of
activities that were to lead the developing countries to greater welfare and prosperity. It included tough
fiscal and monetary policy, deregulation, foreign trade and capital flow liberalisation, elimination of
government subsidies, moderate taxation, liberalisation of interest rates, maintaining low inflation,
etc. From the developmental experience of the past years, a new developmental paradigm is emerging,
the elements of which can be described in the following way:
• basic economic environment should support investments in the long term
• economy should be very sensitive to market stimuli
• human resources should complement physical capital
• information quick flow and absorption in the fast changing world attribute the key role to
the institutions and mechanisms which jointly react to the stimuli.
• Wherever there are market imperfections, state intervention should be market friendly.
• Social equality must be guaranteed if the economic development is supposed to last on
a sustainable basis.
Koncepcja J. Rawlsa racjonalnej sprawiedliwości jako bezstronności a zagadnienia etyki życia gospodarczego
Authors: Szulczewski Grzegorz
Published: February 2023

Rawls’s theory of justice is based on Kant’s ethics and the theory of social contract. Rawls tries to
obey two rules: of universalizations and universality and of the maximization for the least privileged.
His theory can be used to judge the ethical position of business firms. It follows from my studies that a
just organization of a firm is rare in times of transformation. This may be another reason for mass
emigration and it must be taken into account in future debates of the economic development.
Wzrost gospodarczy a optymalne zróżnicowanie dochodów w USA i Szwecji
Authors: Pawlak Witold , Sztaudynger Jan Jacek
Published: February 2023

Inequality of incomes is one of the significant factors forming the social capital. Two views
dominate among economists dealing with the influence of inequality of income on economic growth.
On the one hand, a too low inequality of income does not motivate people to increase the labour
productivity. A low inequality of income might result from an extended social care system
and overloading GDP with social transfers. A good example of it may be a situation when
the unemployed refuses to accept a job offer and prefers the unemployment benefit rather to a slightly
higher salary. Moreover, a lack of incentives for the employee who fails to acknowledge the economic
sense of increasing the productivity of his work might lead to the slower growth of economy.
On the other hand, a contrary view suggests that an increase of the inequality of income has
a negative impact on the economy. The accumulation of wealth by a small number of citizens raises
doubts about good use of that wealth for investments necessary for the growth of the economy.
An excessive inequality of income is confronted with disapproval of the significant part of society
and regarded as unfair and unjustified. It may also increase the crime level and decrease the trust and,
more generally, lead to the weakening of social capital.
The arguments above lead to a hypothesis that the influence of the inequality of income on
the growth of the economy has a non-linear character.
We confirmed this hypothesis in growth models of the US and Swedish economies. We assess
the historically optimal inequality of income measured by the Gini coefficient at 46% and 24% for
the US and Sweden respectively. The optimal inequality of income in Poland was assessed previously at
29%. The dissimilarities may result from the cultural differences, educational level differences, ethnic
differences and differences in diligence.
Problem nisko opłacanych pracowników w Polsce na tle innych krajów gospodarki rynkowej
Authors: Golnau Wiesław
Published: February 2023

Research which has been carried out in countries with developed market economies indicates that
since the 1980s there has been a systematic increase in wage inequality. As a result, low-wage
employment has increased. In recent years, many academic institutions in developed countries have
been conducting research into the scale, causes and consequences of low wages. Such research has not
as yet been systematically carried out in Poland. This article aims to contribute to the research. Its
objective is to establish the scale and causes of low-wage employment in Poland in the last sixteen
years. The contents of the article are divided into three parts. The first part is devoted to the
methodology of measuring low wages. The second part concerns the frequency of low wages in Poland
and other countries with market economies. The third part of the article presents factors influencing the
scale of the occurrence of low wages. According to the research, the number of people in low-wage
employment in Poland systematically increased in the period from 1989 to 2004. In 2004 this number
exceeded 22% of all working people. A similarly high percentage of low-wage employment is found
only in Korea, Hungary, Great Britain, the USA and Canada.
Evaluate the Capability of Some Local Fungal Isolates to Produce Pectinase Enzyme using Some Fruit Peels
Authors: Alsudani Ali A
Published: February 2023

Background: The process of producing enzymes from microorganisms is one of the most current approaches with a bright future. Pectinase is an acidic polysaccharide that is produced by microorganisms, accounts for a large proportion of commercially marketed enzymes and is extremely important because they are used in a variety of industrial, food and medical applications. This study aimed to use the peels of some fruits as a basic material in the production of pectinase enzyme by some fungi isolated from some fruits and vegetables via both solid-state and submerged fermentation methods. Methods: The current study included the isolation and identification of some fungi from fruits and vegetables in the local markets of Al-Diwaniyah City/Iraq, the detection of their capability to produce pectinase enzyme using the standard medium and the possibility of using the peels of some fruits as basic materials. Result: The results indicated the isolation and identification of 178 fungal isolates belonging to 11 genera at different frequency rates and it was found that the isolate P. expansum isolated from Apples was the most efficient isolate in producing pectinase enzyme and the use of Apple peels gave the highest production of the enzyme from the fungal isolate understudy compared to other fruit peels used.
Nile Tilapia Skin as Dermal Wound Healing Promoter in Cats
Authors: Manzoor Arham , Durrani Uzma Farid , Mahmood Asim Khalid , Imran Muhammad , Khan Khizer Ahmed , Fatima Amber , Mateen Abdul
Published: February 2023

Background: In cats major skin injuries need aggressive veterinary assistance for safe and speedy healing. These days Nile tilapia fish skin is gaining hype as wound healing promoter biological dressing in medical field. Keeping in view the successful findings on tilapia skin in human medical practice the present study was designed to evaluate the efficacy of Nile Tilapia fish skin as dermal wound healing promoterin cats. Methods: The study was conducted on 10 clinical cases of cats received with different types of fresh dermal woundsat Department of Small Animal Clinical Sciences, University of Veterinary and Animal Sciences (UVAS), Lahore, Pakistan. Cats were divided into 2 groups i.e. A and B, 5 cats each group. Wounds in group A and B were treated with tilapia fish skin as a biological dressing and as open wounds, respectively. The parameter of study included wound size, physical characteristics of wounds and quality of wound healing and histo-pathological findings. Result: On the basis of findings of this study it was concluded that Nile Tilapia fish skin derived biological dressing promotes the fast, safe and infection free healing of the dermal wounds in cats as compared to open wound healing.
El sueño de Podarces.
Authors: Ramírez Córdova Mario
Published: February 2023

El sueño de Podarces.
MARKETING OF RELIGIOUS PRODUCT TERAS DAKWAH: YOUTH PEOPLE AND THE POPULAR DAKWAH MOVEMENT
Authors: Romadi Pipir , Irham Muhammad , Saputra Eko
Published: February 2023

The da'wah movement in the contemporary era undergoes dynamic and development according to its social context. In this matter, the da'wah movement carried out by the certain community, has several strategies in developing efforts to attract followers and the mass to come in their community. This study endovour to highlight the popular da'wah movement framed by the marketing activities of religious product as its da'wah strategy. Specifically, this study explores the Yogyakarta  Teras Da’wah, which initiates the expansion of da'wah through several product marketing strategies, from various merchandise and marketed products. This research is important to see how youth people develop the da'wah movement through the marketing of religious product. This research used ethnographic study and field observations, to see and follow the da'wah activities of Da'wah Teras directly, and is strengthened by several interview with the administrators and congregations of Teras Da'wah. The result of this study indicated that Teras Da'wah uses the da'wah model as well as doing business as the da'wah movement. They market and sell religious products through recitation and non-recitation, such as traveling, camping, adventure, workshop, training, and futsal in collaborated with youth culture. Da'wah activities through the marketing of religious product include piety, community, lifestyle, identity and enjoyment.
LOCAL WISDOM AS SOCIAL COHESION IN ESTABLISHING INTER-RELIGIOUS LIFE IN DONGGO, DISTRICT OF BIMA
Authors: Nuruddin Nuruddin
Published: February 2023

Cultural values recently have been degraded, and have begun to be forgotten by society due to the times. Yet, apart from that, the certain cultures are very suitable to be developed and preserved. One of the benefits is to realize life together in the frame of religion plurality, realizing social harmonization is a necessity that must be lived by every individual or society. There are several villages in Bima, especially in Donggo that live in multicultural religion frame, one of which is in Mbawa, Tolo Nggeru and Palama Village. The religions that are believed by the community are Islam, Catholics and Protestant. In sulking inter-religion life, there must be a standard of togetherness values so as not bring up polemics in life. Therefore, we can see the social cohesion built by the inter-religious community in the region makes local wisdom a medium in sulking the values of religious moderation. In analysing this research, we used qualitative research with a phenomenological approach, and the process of collecting data through observation, documentation and interviews. Indeed, local wisdom made by community can be used by the community as a value of togetherness in the life inter-religious people. So the local wisdom used is the tradition of “tekara ne’e” and ”Mbolo weki”and  open communication. Really helps the community in sulking the life of  inter-religious society.
Analysis of physiological tremors during different intensities of armcurl exercises using wearable three-axis accelerometers in healthy young men: a pilot study
Authors: Park Wonil , Lee Jaesung , Lee Hyunseob , Hong Gyuseog , Park Hun-Young , Park Jonghoon
Published: February 2023

[Purpose] The purpose of this pilot study was to determine whether physiological tremors (PTs) assessed using an accelerometer could be used to evaluate resistance exercise intensity.[Methods] Twenty healthy young men with no prior experience of resistance exercise were recruited. Different intensities (resting, 30%, 50%, and 70% of their predetermined one-repetition maximum (1-RM)) of arm-curl exercise were used to elicit PT. The total work was held equally by varying the number of repetitions, with five sets for each intensity. Sessions of varying intensities were performed randomly with a washout period of at least a week. PT responses were recorded during exercise using accelerometers (3-axis) attached to the wrist and ear. Electromyography (EMG) data were obtained from the biceps brachii muscle during exercise. PT and EMG data were expressed as the average root mean square index.[Results] The EMG amplitude increased significantly as exercise intensity increased. Furthermore, PT amplitude significantly increased as exercise intensity increased. Moreover, the Borg rating of perceived exertion (RPE) and lactic acid levels increased significantly. The wrist PT was related to ear PT, EMG, RPE, and lactic acid levels. Additionally, ear PT was associated with EMG, RPE, and lactic acid levels.[Conclusion] This pilot study identified changes in PT during resistance exercise at different intensities. We suggest that the use of PT analyses during these exercises provides a more intuitive delineation of resistance exercise intensity and fatigue.
Influência das barras transversais na variação da linha de costa em praia tropical de baixa energia
Authors: Vieira de Jesus Luciana , Pereira Pedro de Souza , Andrade Ana Cláudia da Silva , Nascimento Eduardo Afonso Nunes , Holanda Tiago Fernando
Published: February 2023

Uma série de barras transversais foram identificadas e mapeadas em uma costa arenosa tropical de baixa energia, bordejada por obstáculos naturais na antepraia sob regime de meso marés semidiurnas. As ondas de baixa altura advindas preferencialmente do quadrante SE geram um transporte longitudinal sentido SW-NE. Esse trabalho tem como objetivo analisar a influência das barras transversais no comportamento da praia e na variação da linha de costa do município de Goiana, litoral norte do estado de Pernambuco. O mapeamento multitemporal de médio (2007-2017) e curto prazo (2017-2018) das barras e da linha de costa foi confeccionado utilizando imagens de satélite e ortomosaicos derivados de sobrevoos com sistema de Aeronave Remotamente Pilotada (ARP). A taxa de variação da linha de costa foi calculada utilizando a extensão Digital Shoreline Analysis System (DSAS). A área de estudo foi dividida em três setores: norte, central e sul e foram observados cinco grupos preferenciais de barras a depender do ângulo formado entre a crista e a linha de costa. As barras transversais ocorrem em maior proporção (> 10) nos setores central e norte. Além disso, o processo de erosão predominou no setor sul e central e a deposição predominou no setor norte. Possivelmente, as ondas e transporte longitudinal retiraram os sedimentos do setor sul e transportaram para o setor norte depositando-os devido à zona de sombra gerada pelo recife de calcário. A análise da interação entre a praia e as barras transversais são fundamentais para o entendimento dos ambientes costeiros e gestão das zonas costeiras
EVALUASI KURIKULUM PENDIDIKAN INKLUSI DI MADRASAH ALIYAH NEGERI 2 SLEMAN YOGYAKARTA
Authors: Fauziah Ni’matul , Munsyifah Abidah , Purwanto Muhammad Roy
Published: February 2023

Pada dasarnya pendidikan merupakan proses tranformasi pengetahuan menuju arah perbaikan yang tidak mengenal waktu dan tempat. Terdapat istilah pendidikan inklusi yaitu pelayanan pendidikan yang layak untuk semua anakanak termsuk yang memiliki kebutuhan khusus. Istilah merupakan kata dari UNESCO yang berasal dari Education for All. Madrasah Aliyah Negeri 2 Sleman Yogyakarta menjadi salah satu pelopor pendidikan inklusi di lingkungan Kementrian Agama daerah Istimewa Yogyakarta serta mampu menerima dan menampung siswa difabel. Jenis penelitian ini adalah penelitian evaluasi (evaluation research) dengan pendekatan kualitatif. Penelitian evaluasi ditujukan untuk mengevaluasi bagaimana pelaksanaan dan perkembangan kurikulum pendidikan inklusi di Madrasah Aliyah Negeri 2 Sleman Yogyakarta. Serta melihat manfaat dan hambatan dalam penerapan kurikulum ini.
Mitochondrial Bioenergy in Neural Disease: Huntington and Parkinson
Authors: Tassone Annalisa , Meringolo Maria , Bonsi Paola , Schirinzi Tommaso , Martella Giuseppina
Published: February 2023

Much evidence suggests a correlation between degeneration and mitochondrial impairment. Typical cases of degeneration can also be observed in physiological phenomena (aging) as well as in neurological neurodegenerative diseases and cancer. All these pathologies have as a common denominator the dyshomeostasis of mitochondrial bioenergy. Even neurodegenerative diseases show a bioenergetics imbalance in their pathogenesis or progression. Huntington's chorea and Parkinson's disease are both neurodegenerative diseases, but while Huntington's disease is a genetic, and progressive disease with early manifestation and severe penetrance, Parkinson's disease is a pathology with a multifactorial aspect. Indeed, there are different types of Parkinson/Parkinsonism. Many forms are early onset diseases linked to gene mutation, others can appear in young adults and senescent only post-injury, and a final group is idiopathic. Huntington's was defined as a hyperkinetic disorder, while Parkinson's is a hypokinetic disorder; but in the middle, there are a lot of similarities as well as neuronal excitability, the loss of striatal function, psychiatric comorbidity, etc. In the review, we would embrace the theories that both diseases start and develop in light of mitochondrial dysfunction. These dysfunctions act on energy metabolism and reduce the vitality of neurons in many different brain areas.
Demographic and Socioeconomic Determinants Are Associated with Poor Preoperative Patient-Reported Pain and Function in Primary TKA
Authors: Vega Jose , Emara Ahmed K. , Orr Melissa , Klika Alison K. , Piuzzi Nicolas S. ,   the Cleveland Clinic Arthroplasty Group
Published: February 2023

Background:

Pain and function, as reflected by patient-reported outcome measures (PROMs), can influence improvement after total knee arthroplasty (TKA) and can reflect the extent of patient access to orthopaedic surgical care. We aimed to (1) categorize patients according to pain and function PROM phenotypes, (2) identify patient characteristics associated with poor preoperative pain and function, and (3) assess relationships between baseline characteristics and PROM phenotypes.

Methods:

A prospective cohort of 14,079 TKAs was enrolled. Demographics, comorbidities, surgical details, and preoperative PROMs were collected. Outcomes included preoperative Knee injury and Osteoarthritis Outcome Score (KOOS) Pain (P) and Physical Function (PS) subscores, stratified by demographics. Patients were then categorized into 4 PROM phenotypes defined on the basis of the cohort medians: above or equal to the median for both pain and function scores (P+PS+), below the median for both pain and function (P−PS−), above or equal to the median for pain but below the median for function (P+PS−), and below the median for pain but above or equal to the median for function (P−PS+). Descriptive statistics and multivariable regression analyses were calculated.

Results:

The largest PROM phenotype was P−PS− (39.4%), followed by P+PS+ (38.9%). The cohort with discordantly poor function but high pain scores (less pain) was the smallest cohort (9.9%). Preoperative KOOS-Pain and KOOS-PS scores at or below the 25th percentile were independently associated with younger age, female sex, higher body mass index (BMI), non-White race, current smoking, lower education, non-commercial insurance, and higher Charlson Comorbidity Index (CCI). Multivariate logistic regression showed that patients in the P+PS+ category were older (odds ratio [OR] = 1.56), were more likely to be male (OR = 2.00), had a lower BMI (OR = 0.67), had more education (OR = 1.63), had a lower CCI, and were less likely to be Black (OR = 0.80) or Other (OR = 0.62) race, be a current smoker (OR = 0.62), and have commercial insurance (OR = 0.74), compared with the P−PS− phenotype.

Conclusions:

Younger age, obesity, non-White race, female sex, current or recent smoking, non-commercial insurance, and higher CCI were associated with worse pre-TKA PROMs and poor pain-function phenotype combinations. Such a pattern may indicate barriers to TKA access among these patient populations leading to advanced levels of impairment at the time of treatment.

Level of Evidence:

Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
Lateral Patellar Instability
Authors: Drapeau-Zgoralski Véronique , Swift Brendan , Caines Andrew , Kerrigan Alicia , Carsen Sasha , Pickell Michael
Published: February 2023

➤ Patellar instability represents a common problem with an evolving understanding and multifactorial pathoetiology. Treatment plans should be based on the identification of contributing anatomical factors and tailored to each individual patient.

➤ Risks for recurrent instability are dependent on several patient-specific factors including patella alta, increased tibial tubercle-to-trochlear groove (TT-TG) distance, trochlear dysplasia, younger skeletal age, and ligamentous laxity.

➤ Cartilage or osteochondral lesions and/or fractures are commonly observed in first-time patellar dislocation, and magnetic resonance imaging (MRI) should be strongly considered. Advanced imaging modalities, such as computed tomography (CT) or MRI, should also be obtained preoperatively to identify predisposing factors and guide surgical treatment.

➤ Medial patellofemoral ligament (MPFL) reconstruction with anatomical femoral tunnel positioning is associated with lower recurrence rates compared with MPFL repair and has become a common and successful reconstructive surgical option in cases of instability.

➤ Lateral retinacular tightness can be addressed with lateral retinacular release or lengthening, but these procedures should not be performed in isolation.

➤ Tibial tubercle osteotomy is a powerful reconstructive tool in the setting of underlying skeletal risk factors for instability and can be of particular benefit in the presence of increased TT-TG distance (>20 mm), and/or in the setting of patella alta.

➤ The indications for trochleoplasty are still developing along with the clinical evidence, but trochleoplasty may be indicated in some cases of severe trochlear dysplasia. Several surgical techniques have indications in specific clinical scenarios and populations, and indications, risks, and benefits to each are progressing with our understanding.

➤ Combined femoral derotational osteotomy and MPFL reconstruction can be considered for patients with a femoral anteversion angle of >30° to improve patient outcomes and reduce recurrence rates.
There Must Be a Better Way
Authors: Lieber Richard L.
Published: February 2023

The National Institutes of Health (NIH) R01 grant represents the gold standard for research independence across the United States. The barrier to entry for this grant mechanism is extremely high, with <10% of grants being funded. Interestingly, after this tremendously high barrier, there is very little accountability for the grantee to accomplish the aims that were originally proposed. While there is certainly value to requiring investigators to provide a logical and compelling research plan, excessive grant writing creates a large inefficiency. Thus, a “fail quickly” model, which is not without cost, should be considered. Such a model involves a much lower barrier to entry and much higher short-term accountability so that more aims can be tested in less time at lower cost.
Design Of Web-Based Coffee Sales System (Case Study: CV Cahaya Abadi)
Authors: Azizi Muhammad Choir Ridho , Findawati Yulian
Published: February 2023

In this era of interconnectedness, technological progress occurs very quickly. One technology that istrending and has been widely accepted by almost everyone around the world is e-commerce. However, in Indonesiaitself, there are still many businesses that are still done conventionally, such as CV. Cahaya Abadi. This causesbusiness processes to not work efficiently, especially during transaction processing. Another problem is the lack ofreporting tools that accurately reflect performance indicators such as total customers and total sales volume, so thatcompany performance cannot be monitored. The purpose of this research is to create an integrated web-based salessystem that is intended as an integrated sales system that has various features for users and allows Cahaya Abadi tomanage the entire business in one place in a structured manner. In this study, the waterfall method is used as adevelopment method. The result of this research is a web-based sales system that is expected to be useful for salesmedia and transaction monitoring. Based on the results, the percentage of the overall quality of the sales system is84%, so this system is feasible for mass use.
A novel decision-making approach based on sine trigonometric cubic Pythagorean fuzzy aggregation operators
Authors: Rahim Muhammad , Amin Fazli , Ali Asad
Published: February 2023

The objective of this study is to imitate several efficient sine-trigonometric operational laws to handle the decision-making process under the cubic Pythagorean fuzzy set environment. The sine-trigonometric function provides the periodicity and symmetry of the origin in nature and satisfies the potentials of decision-makers over the considerations of the decision-making process. keeping the advantages of the sine function and the significance of the cubic Pythagorean fuzzy set, we demonstrate the novel sine trigonometric operational laws under the cubic Pythagorean fuzzy environment. Based on these operational laws, novel sine trigonometric cubic Pythagorean fuzzy aggregation operators are developed. This study mainly focuses on a decision-making approach for multi-criteria decision-making problems that is based on proposed aggregation operators with given weight information of the criterion. Lastly, to demonstrate the efficiency, an illustration is presented. Sensitivity and comparison analyses are used to evaluate the method’s permanency and rationality.
A Fully Autonomous Robotic Ultrasound System for Thyroid Scanning
Authors: Su Kang , Liu Jingwei , Ren Xiaoqi , Huo Yingxiang , Du Guanglong , Zhao Wei , Wang Xueqian , Liang Bin , Li Di , Liu Peter
Published: February 2023

The current thyroid ultrasound relies heavily on the experience of the sonographer and radiologist, which would be physically and cognitively exhausting. Here we report a novel fully autonomous robotic ultrasound system (FARUS) that can scan thyroid regions without human assistance. In this application, human skeleton point recognition, image segmentation, and force feedback are used to solve the problem of thyroid localization. The orientation of the ultrasound probe is adjusted via Bayesian optimization. By using FARUS, both transverse and longitudinal scanning of thyroid tissue can be performed, as well as real-time thyroid nodule detection with artificial intelligence (AI) algorithms. Experimental results on human participants demonstrate that FARUS can perform high-quality ultrasound scans in comparison with manual scans obtained by clinicians.
Identification of Immune-Related Target and Prognostic Biomarkers in PBMC of hepatocellular carcinoma
Authors: Hu Rui , Zhang Wei , Ma Mengqing , Huang Qi , Lv Minling , Ma Wenfeng , Sun Xinfeng , Feng Wenxing , Li Jing , Zhong Xin , Sun Jialing , Yao Wei , Zhou Xiaozhou , Han Zhiyi
Published: February 2023

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide, and is characterized by insidious onset, rapid progression and poor prognosis. In recent years, several biomarkers have been identified for early screening of HCC, although novel prognostic biomarkers still need to be explored. In this study, we compared the transcriptomes of 6 deceased and 6 living HCC patients using DESeq2, edgeR and Limma programs, and identified 43 differentially expressed genes (DEGs). The top 10 DEGs were validated by RNA-Seq analysis of peripheral blood mononuclear cells (PBMCs) isolated from HCC patients of different BCLC stages. The expression levels of METTL7B, CLDN18, SOCS3, ITGA9 and RNASE3 correlated positively with the BCLC stage. Moreover, CLDN18 proteins were significantly upregulated in the tumor tissues, but also associated with HCC stage, tumor grade and poor prognosis. Functional annotation of CLDN18 in HCC revealed enrichment of the cellular senescence, mRNA surveillance, metabolism of xenobiotics by cytochrome P450 and Human T-cell leukemia virus 1 infection pathways, along with biological processes such as cell cycle, inflammatory response and cellular ketone metabolism. In addition, CLDN18 was also associated with tumor infiltrating immune cells, suppressive immune cell markers, T lymphocyte depletion and activation of HCC, and low expression of CLDN18 was associated with higher CD8+T cell infiltration and better survival rates. These results suggest that CLDN18 is a potential prognostic marker and immunotherapeutic target for HCC.
Transition models of care for Type 1 Diabetes: a systematic review
Authors: Zurynski Yvonne , Carrigan Ann , Meulenbroeks Isabelle , Sarkies Mitchell N , Dammery Genevieve , Halim Nicole , Lake Rebecca , Davis Elizabeth , Jones Timothy W , Braithwaite Jeffrey
Published: February 2023

Background
Managing the care regimen for Type 1 Diabetes (T1D) is challenging for emerging adults, as they take on greater responsibility for self-management. A diverse range of models of care have been implemented to improve safety and quality of care during transition between paediatric and adult services. However, evidence about acceptability and effectiveness of these is limited. Our aim was to synthesize the evidence for transition models and their components, examine the health related and psychosocial outcomes, and to identify determinants associated with the implementation of person-centred models of transition care.
Method
We searched Medline, CINAHL, EMBASE and Scopus. Peer reviewed empirical studies that focused on T1D models of care published from 2010 to 2021 in English, reporting experimental, qualitative, mixed methods, and observational studies were included.
Results
Fourteen studies reported on health and psychosocial outcomes, and engagement with healthcare. Three key models of care emerged: structured transition education programs (6 studies), multidisciplinary team (MDT) transition support (5 studies) and telehealth/virtual care as an integral component of a broader model (3 studies). Compared with usual practice, three of the six structured transition education programs led to improved maintenance of glycaemic control, improved psychological well-being, and improved engagement with health services. Four MDT transition care models reported improved health outcomes, and improved engagement with health services, however, three studies reported no benefit. Reduced diabetes related stress and increased patient satisfaction were reported by two studies, but three reported no benefit. Telehealth and virtual group appointments improved adherence to self-management and reduced diabetes distress but no change in health outcomes. No study reported on implementation determinants or applied an implementation framework to guide their research.
Conclusions
Although some health and psychosocial benefits are reported, the results were mixed. No studies reported on T1D transition model implementation outcomes such as acceptability, adoption, and appropriateness among clinicians or managers implementing these models. This gap needs to be addressed to support future adoption of successful models.
The safety and tolerability of Annona muricata leaf product in people living with cancer: study protocol
Authors: Chan Wai-Jo Jocelin , Beale Philip , McLachlan Andrew J , Hanrahan Jane R , Harnett Joanna E
Published: February 2023

Background: Annona muricata, also known as graviola, soursop and guanabana is a herbal product used by people living with cancer. Anecdotal clinical evidence suggests this herb has potential anti-cancer activity. There are numerous pre-clinical studies detailing Annona muricata’s main bioactive constituents. To date, clinical studies evaluating the efficacy, safety and tolerability are limited. This study aims to investigate the safety and tolerability of Annona muricata leaf in people living with advanced malignancy.
Methods: This open label pilot study will involve people living with stage III and IV cancers of any type, who are not undergoing chemotherapeutic treatment. The primary outcome is safety and tolerability of an Annona muricata leaf product in this population assessed by participants’ self-reporting of adverse effects experienced and the proportion of participants completing the study. Secondary outcomes include biomarkers of inflammation and immune function, disease status and self-reported quality of life scores. Participants (n = 24) will be allocated to one of two groups for 12 weeks. Participants will commence at different timepoints and be assigned to either 530 mg or 1060 mg of Annona muricata daily. The study has been approved by the Human Research Ethics Committee Bellberry (2022-04-420) and will be conducted in compliance with the SPIRIT statement.
Discussion: The results of this study will provide safety and tolerability data for clinicians involved in the care of people living with cancer who choose to use Annona muricata products as an integrative approach to their healthcare. The results of this study will inform further research about the potential role of Annona muricata in cancer.
Trial registration: This study has been registered with the Australian New Zealand Clinical Trials Register (ACTRN 12622001288718)
A Torsional Pneumatic Joint for Spacesuit Inspired with Origami Structure
Authors: Shang Kun , Li Meng , Yang Hong-Rui , Liu Shao-Jie
Published: February 2023

For exploration of the deep space destinations like the planetary surfaces, one of the most significant challenges is the performance of the spacesuit system. Aimed at improving safety and flexibility for the human-suit system during extravehicular activities (EVAs), a novel torsional pneumatic joint (TP joint) is proposed inspired with origami structure, overcoming the defects of traditional airtight bearings. Geometry of the TP joint is designed with Kresling crease pattern at first. To study the mechanical property of the TP joint, a basic structure of two layers is abstracted and analyzed with the energy method and nonlinear finite element method. According to analysis, the constitution of resistance torque is discussed and two influence factors of material rigidness and air pressure are investigated. As the inner pressure becomes large, the inflatable structure is unstable and tends to swell asymmetrically. Meanwhile, based on an eight-layer prototype joint, torsional and bending tests are conducted under inner pressure to examine the mobility of the joint. Results show that the prototype joint can be twisted to a range of 40°in one direction, and the torque is much smaller than the critical buckling torque of a pneumatic tube. Besides, the prototype joint also equips the bending function with a relatively low torque as an ordinary soft spacesuit joint. Thereby, the proposed TP joint can realized the torsional operations and has the potential to function as rigid bearings. Besides, the TP joint can be designed as a multi-degree joint to provide more mobility for the spacesuit system.
Strategic feeding of the prepubertal Nellore heifers improves body development and increases the number of recovered oocytes, viable oocytes and embryos produced in vitro.
Authors: Toledo Ricardo Braz , de Faria Otávio Augusto Costa , Leme Ligiane Oliveira , Magnabosco Cláudio Ulhoa , Guimarães Roberto , Eifert Eduardo da Costa , Santos Isabella Rodrigues dos , Oliveira Rodrigo Vidal , Dode Margot Alves Nunes , Malaquias Juaci Vitoria , Pivato Ivo , Martins Carlos Frederico
Published: February 2023

The objective of this work was to determine the effect of two different feeding plans on quantity and quality of oocytes and in vitro embryo production, as well as on the body development of prepubertal Nellore heifers. After weaning, thirty-three Nellore heifers were divided into two experimental groups and supplemented with two nutritional plans according to dry and rainy seasons. For nutritional plan 2 the animals received diets containing 26% and 19% more metabolizable energy (ME) related to NP1 in the dry and rainy seasons, respectively. After 3.5 months of supplementation (i.e., at 10 months old), animals from both groups underwent follicular aspiration (OPU) every 21 days and in vitro produced embryos (IEP). Withers height, chest depth and body weight of all animals were measured monthly. Subcutaneous fat deposition was measured at the end of the study by ultrasonography. The number of retrieved COCs per OPU and viable oocytes was respectively 49% and 42% greater in NP2 heifers (p=0.018 and p=0.049). Regarding the blastocysts rate, heifers administered NP2 produced 29.7% of blastocysts, a percentage higher than NP1 treatment animals that produced 24.40% of embryos (p<0.05). Consequently, the females from NP2 treatment presented a greater final weight, chest depth, carcass finish, in addition to a greater accumulation of subcutaneous fat. These results indicating a positive effect of diet slightly higher in energy in the assisted reproduction of Nellore prepubertal heifers and also on weight gain and fat deposition in the carcass, allowing these females to reach the suggested early mating conditions.
Umbilical cord mesenchymal stem cell-derived apoptotic extracellular vesicles ameliorate cutaneous wound healing in type 2 diabetic mice via macrophage pyroptosis inhibition
Authors: Wang Yiming , Jing Lin , Lei Xiao , Ma Zhen , Li Bei , Shi Yuanyuan , zhang Wuyang , Li Yuan , Zhou Hongzhi , Hu Kaijin , Xue Yang , Jin Yan
Published: February 2023

Background: Delayed healing of diabetic cutaneous wounds is one of the most common complications of type 2 diabetes mellitus (T2DM), which can bring great distress to patients. In diabetic patients, macrophages accumulate around skin wounds and produce NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) inflammasomes, which in turn undergo pyroptosis and produce inflammatory factors such as interleukin-1β that affect wound healing. Although our previous study revealed that apoptotic extracellular vesicles (ApoEVs) produced from mesenchymal stem cells (MSCs) improve cutaneous wound healing in normal C57BL/6 mice, whether ApoEVs can also improve diabetic wound healing remains unclear.
Methods: Umbilical cord mesenchymal stem cells (UCMSCs) were cultured in vitro and apoptosis was induced. ApoEVs were extracted and identified and used in a T2DM mouse cutaneous wound model to evaluate the efficacy. The inhibitory effect of ApoEVs on macrophage pyroptosis was verified in vivo and in vitro, and the level of oxidative stress in macrophages was assessed to explore the mechanism by which ApoEVs play a role.
Results: UCMSC-derived ApoEVs improved skin defect healing in T2DM mice. Moreover, UCMSC-derived ApoEVs inhibited macrophage pyroptosis in T2DM mice in vivo as well as in vitro under high glucose culture conditions. In addition, we demonstrated that ApoEVs reduce oxidative stress levels, which is a possible mechanism by which they inhibit macrophage pyroptosis.
Conclusions:Our study confirmed that local application of UCMSC-derived ApoEVs improved cutaneous wound healing in T2DM mice. ApoEVs, as products of MSC apoptosis, can inhibit macrophage pyroptosis and regulate the death process by decreasing the level of oxidative stress.
Design and modeling of a wearable articulated manipulator to assist the elderly grasp
Authors: Lu yishanchun , Li hongshuang , Liu manchang , Li yiming
Published: February 2023

Purpose –With the weakening of the body of the elderly, hand strength has decreased significantly, unable to adapt to daily life, some elderly people with Parkinson’s syndrome or some hand tremors caused by other diseases, and even will have trouble drinking water and eating daily small things. In order to solve the problem of grasping objects in daily life of the elderly with weak hand strength and some diseases, a wearable articulated manipulator that assists the elderly to grasp is designed.
Design/methodology/approach –The design is divided into four parts: wrist part, back part of the hand, finger part and drive part. For the elderly with trembling hands, the degree of freedom is reduced at the joint point of finger movement, and the use of underdrive mechanism can make the knuckles of the mechanical finger fit the shape of the object by themselves, and when taking irregular objects, the fingers will adaptively fit the outline of the object, ensuring the stability and safety of the overall grasping to the greatest extent.
Findings –Based on this design idea, a wearable articulated manipulator was designed, and mechanical analysis and kinematics analysis were carried out by designing and modeling the claw mechanism, determining the design size, and making the manipulator claw. Through the manipulator-assisted grasping and opening and lifting test tests, the practicality and safety of the designed assisted elderly grasping items are verified.
Originality/value –The morphological design of each finger is designed to fit the normal human hand, and each "joint" can be fine-tuned to adapt to the finger length of different elderly people. Each finger is biomimetically designed to perfectly conform to the human skeletal structure, while the interior is covered with flexible materials to make it more comfortable for the elderly to wear. And it has stable grasping ability and adjustment ability, reflecting good adaptability and suitable for the elderly.
RETRACTED: Experimental investigations of CO2 capture using adsorbents in a standby power generation unit
Authors: Ravi Maniarasu , Rathore Sushil Kumar , Sivalingam Murugan
Published: February 2023

The authors have requested that this preprint be removed from Research Square.
Stochastic Modeling of the Theis Equation via Karhunen–Loeve and Polynomial Expansions
Authors: Mohsenian Ahmadreza , Khorshidi Hossein , Szymkiewicz Romuald
Published: February 2023

Groundwater is a vital water resource which has a significant role in the irrigation and food industry. Drawdown is a change in groundwater level due to various causes, especially pumping from wells. Forecasting water level oscillations is an important necessity for planning the integrated management of any watershed basin. In the present study, the Theis equation was applied to stochastic analysis of groundwater flow in confined aquifers, through the Karhunen–Loeve expansion (KLE) method. The quantification of the uncertainty associated with the statistical moments of hydraulic head is the aim of this research. The KLE method takes two steps; first, aquifer transmissivity (T) as an input random field is decomposed in the form of a set of orthogonal Gaussian random expressions in which eigen structures related to the covariance function of T were obtained from the Fredholm equation. Then, the hydraulic head h(x,t) was expanded with polynomial terms in which some coefficients were computed from the governing equation. The statistical moments (i.e., mean values and variances) of h(x,t) were calculated and compared with Monte Carlo simulations (MCS) to validate the results.
Carcinoma-associated fibroblast-derived lysyl oxidase-rich extracellular vesicles mediate collagen crosslinking and promote epithelial-mesenchymal transition via p-FAK/p-paxillin/YAP signaling
Authors: Liu Tingjiao , Liu Xue , Li Jiao , Yang Xuesong , Li Xiaojie , Kong Jing , Qi Dongyuan , Zhang Fuyin , Sun Bo , Liu Yue-Hua
Published: February 2023

Carcinoma-associated fibroblasts (CAFs) are the main cellular components of the tumor microenvironment and promote cancer progression by modifying the extracellular matrix (ECM). The tumor-associated ECM is characterized by collagen crosslinking catalyzed by lysyl oxidase (LOX). Small extracellular vesicles (sEVs) mediate cell-cell communication. However, the interactions between sEVs and the ECM remain unclear. Here, we demonstrate, for the first time, that sEVs released from oral squamous cell carcinoma (OSCC)-derived CAFs induce collagen crosslinking, thereby promoting epithelial-mesenchymal transition (EMT). CAF sEVs preferably bound to the ECM rather than being taken up by fibroblasts and induced collagen crosslinking, and a LOX inhibitor or blocking antibody suppressed this effect. Active LOX (αLOX), but not the LOX precursor, was enriched in CAF sEVs and interacted with periostin, fibronectin, and bone morphogenetic protein-1 on the surface of sEVs. CAF sEV-associated integrin α2β1 mediated the binding of CAF sEVs to collagen I, and blocking integrin α2β1 inhibited collagen crosslinking by interfering with CAF sEV binding to collagen I. CAF sEV-induced collagen crosslinking promoted the EMT of OSCC through p-FAK/p-paxillin/YAP signaling in vitro and in vivo. Taken together, these findings reveal a novel role of CAF sEVs in tumor ECM remodeling, suggesting a critical mechanism for CAF-induced EMT of cancer cells.
Combination therapy with platelet-rich plasma and epidermal neural crest stem cells increases treatment efficacy in vascular dementia
Authors: Akbari Somayeh , Haghani Masoud , Ghobadi Mojtaba , Hooshmandi Etrat , Haghighi Afshin Borhani , Salehi Mohammad Saied , Pandamooz Sareh , Azarpira Negar , Afshari Afsoon , Zabihi Shahrbanoo , Nemati Marzieh , Bayat Mahnaz
Published: February 2023

This study aimed to evaluate effects of platelet-rich plasma (PRP) and neural crest-derived epidermal stem cells (ESC) in alone administration and their combination in vascular dementia (VaD) model by tow-vessels occlusion (2VO). Methods the rats were divided into control, sham, 2VO + vehicle, 2VO + PRP, 2VO + ESC, and 2VO + ESC + PRP groups. The treated-groups received one million cells on days 4, 14, and 21 with or without 500µl PRP (twice a week). The behavioral performance was evaluated by open-field, passive-avoidance, and Morris-water maze. The basal-synaptic transmission (BST) and long-term potentiation (LTP) were assessed by field-potential recording. The mRNA expression levels of IGF-1, TGF-β1, PSD-95, and GSk-3β were measured in rat hippocampus by qRT-PCR. Results The results showed a learning, memory, and synaptic plasticity impairment with a significant decrease in IGF1, TGF-β1, PSD-95, and increase in expression of GSk-3β 2VO rats. Although treatment with ESC alone and ESC + PRP show comparable improvement effects on spatial memory and LTP induction associated with PSD-95 up-regulation and GSK-3β down-regulation, the BST only recovered in the ESC + PRP group. Moreover, combination therapy was superior to monotherapy with PRP. Conclusions The transplantation of ESC showed better effects than PRP alone, and combination therapy increased treatment efficacy with the recovery of BST.