bluuebunny/crossref_metadata_2025 huggingface dataset:
MEMBANGUN SISTEM INFORMASI AKADEMIK BERBASIS WEB PADA PONDOK PESANTREN SALAFIYAH AL-BAQIYATUSSA’DIYYAH TEMBILAHAN
Authors: Burrahman Abi
Published: October 2018

Information system are running at the Islamic School Salafiyah Al-Baqiyatussa’diyyah Tembilahan, that the academic data processing still using a simple computerized system. Althought it is supported by the computer but only use standard office (Microsoft Office Excel and Word) that allows a lot of errors in the processing of academic data, and the cause of academic services providedby the Islamic school Salafiyah Al-Baqiyatussa’diyyah Tembilahan to be less efficient, and the resulting difficulty in data search and seize a relatively long time in the making of the report. To assist in solving these problem is need fr a new academic information system so that any work involving the processing of data can be reduced and the error rate can provide satisfactory services of the user the system. On the design of academic information system is ilustrated in the diagram Unified Modelling Language (UML).Keyword : Akademik, Sistem Informasi, SDLC, UML.
APLIKASI MANAJEMEN E-SKRIPSI ONLINE (STUDI KASUS PRODI SISTEM INFORMASI UNIVERSITAS ISLAM INDRAGIRI)
Authors: Patimah Siti
Published: October 2018

Universitas Islam Indragiri (UNISI) adalah salah satu perguruan tinggi di Provinsi Riau tepatnya terletak di Kecamatan Tembilahan Kabupaten Indraigir Hilir. Universitas Islam Indragiri saat ini memanfaatkan peran teknologi informasi untuk memudahkan mahasiswa melakukan pengajuan judul skripsi berbasis Web. Tujuan dari penelitian ini adalah membangun sebuah website E-Skripsi Universitas Islam Indragiri untuk dapat mempermudah mahasiswa dalam hal mengajukan judul skripsi serta memudahkan dosen dalam hal pelayanan terhadap mahasiswa. Metode dari penelitian ini adalah analisis sistem, perancangan, pemrograman, uji coba dan implementasi. Pengujian website E-Skripsi ini menggunakan metode Blackbox yaitu pengujian berdasarkan fungsionalitas aplikasi dan metode Whitebox yaitu pengujian berdasarkan Interface website. Dengan dibangunnya Website E-Skripsi ini diharapkan dapat memudahkan mahasiswa dalam hal mengajukan judul skripsi. Kata Kunci : UNISI, Blackbox, Whitebox, Web
Percepción sobre el desempeño docente y gestión del conocimiento en estudiantes de educación secundaria
Authors: Alván More Eugenia Yolanda
Published: October 2018

El objetivo principal de la investigación fue establecer el grado de relación entre percepción del desempeño docente y gestión de conocimientos en estudiantes de educación secundaria. El diseño de estudio es correlacional y la muestra estuvo conformada por 86 estudiantes a quienes se les administró dos cuestionarios el de percepción de desempeño docente, que se elaboró en base al Manual de buenas prácticas de evaluación del desempeño profesional de los docentes de Valdez (2009), y el de gestión del conocimiento, que se elaboró en base a la obra, autoevaluación de la calidad educativa en escuelas secundarias de UNICEF-CEADEL (2013). A partir del análisis de los datos obtenidos se pudo demostrar que existe una relación significativa entre desempeño docente y gestión del conocimiento de los estudiantes
Implementasi Sistem Rekam Medis Pasien Menggunakan Pendekatan Customer Relationship Management (CRM)
Authors: Wiyanto Wiyanto , Butsianto Fajar , Karsito Karsito
Published: October 2018

Information technology is rapidly developed in this century that impact to various aspects of the organization really need information technology to support the performance and everyday business processes. In health services, information technology is required to process and storage the patient medical records, so that the patient's medical record is well preserved, and competitive advantage can be obtained between patient and polyclinic. The application of Customer Relationship Management (CRM) approach can be developed by implementing information system of medical record history to get new patient and retain existing patient, improving relationship with patient and maintaining patient loyalty as well as supporting the company/organization to provide excellent service to customers in real time through the advantage of information technology. The aims of this research are to understand patient medical record by CRM approach and Unified Modeling Language (UML) for system design, system validation using Forum Group Discussion (FGD), and using software testing Model ISO 9126. The result of this research are Medical Record History Information System and the result of system validation with FGD is 100% accepted, the result of system test using Model ISO 9126 is good with success rate 82,86%, so it can give contribution to polyclinic.
Web-Based Mapping Untuk Pemetaan Lokasi Kerusakan Jalan Raya Menggunakan Cluster Marker
Authors: Pinem Agusta Praba Ristadi
Published: October 2018

Online mapping has developed rapidly over the past few years resulting to replace GIS functionality. This system allows users to use appliacation without using specialized GIS software. The system can receive data from multiple sources and display the map to all users. These developments bring web-based mapping technology. Web-based mapping using MapsAPI as third-party tools. MapsAPI allows system to mapping data in real time and real location. That information technology can support smart city program’s to solve several problem in a city like mapping the location of the damaged roads. Users only need to use internet browsing application to add location or observe the map of road damage. People and government as system user’s, can utilize the system to determine the priority of roadwork.
Evaluasi Penggunaan Aplikasi Office Berbasis Open Source Pada SMKN Kota Palembang Dengan Pendekatan Technology Acceptance Model
Authors: Surahmat Surahmat , Tenggono Alfred
Published: October 2018

Dalam penerapannya Aplikasi office yang biasa di ajarkan khususnya di SMK biasanya menggunakan produk keluaran microsof yang merupakan apikasi berlisensi, sehingga sering ditemui penggunaan aplikasi office bajakan di komputer maupun laptop dari siswa atau siswi SMK. Untuk mengurangi penggunaan aplikasi bajakan maka perlu diajarkan sejak awal penggunaan aplikasi yang besifat open source, mulai dari penggunan sistem operasi maupun penggunaan software office penelitian ini bertujuan untuk melihat seberapa besar penerimaan siswa dan siswi SMKN Kota Palembang dalam menggunakan aplikasi office berbasis open source dengan menggunakan pendekatan Technology Acceptance Model. Penelitian ini dilakukan dengan melalui beberapa tahapan mulai dari tahapan pengumpulan data kemudian mengidentifikasi masalah yang sesuai dengan pembahasan pada penelitain ini lalu ditentukan indikator apa saja yang akan di ukur untuk mengetahui tingkat penerimaan teknologi lalu data tersebut diolah dengan perhitungan quisoner dan tahapan akhir ialah melakukan analisis terhadap data tersebut. Berdasarkan hasil analisis data pada penelitian ini didapatkan hasil berupa persepsi kemudahan memperoleh nilai rata rata sebesar 4.03 yang berarti responden beranggapan bahwa penggunaan aplikasi office berbasis open source mudah dalam penggunaan, untuk persepsi kemanfaatan sebesar 3.98 yang berarti aplikasi office berbasis open sources bermanfaat, untuk persepsi sikap pengguna sebesar 3.77 yang berarti penggunaan aplikasi office berbasi open source mendapatkan nilai sikap yang baik, untuk perilaku untuk tetap menggunakan sebesar 3.58 yang berarti respondent berencana untuk terus menggunakan aplikasi office berbasis open sources, dan untuk kondisi nyata dalam penggunaan sistem sebesar 3.45 yang berarti penggunaan secara aktual aplikasi office berbasis open source sudah baik
Implementasi Metode RAD Pada Website Service Guide “Tour Waterfall South Sumatera”
Authors: Puteri Meidyan Permata , Effendi Hendra
Published: October 2018

Berwisata sudah menjadi bagian dari kebutuhan sebagian masyarakat Indonesia, tidak hanya bagi kelompok ekonomi mapan, tetapi masyarakat kelas menengah dan bawah pun mulai memandang penting wisata sebagai momen rekreasi keluarga. Potensi objek-objek wisata air terjun di seluruh provinsi Indonesia belum digali secara optimal, begitu juga halnya dengan promosi belum gencar dilakukan apalagi dengan menggunakan media online atau digital. Maka dari itu perlunya rancang bangun website service guide “Tour Waterfall South Sumatera” di karnakan belum adanya website khusus promosi yang lengkap tentang objek-objek wisata air terjun yang ada di Provinsi Sumatera Selatan. Metode pembuatan aplikasi ini menggunakan metode perancangan sistem Rapid Application Development (RAD), yang dimulai dengan yaitu tahapan requirement planning, system design, dan implementation.
Peningkatan Keamanan Pesan Berbasis Android Menggunakan Algoritma Kriptografi RSA
Authors: Sulaiman Rahmat , Vebu Marina
Published: October 2018

Keamanan dan kerahasiaan sebuah data atau informasi merupakan hal yang sangat penting, baik dalam suatu organisasi seperti perusahaan, perguruan tinggi, maupun individual. Itu dikarenakan seringkali data atau informasi yang penting kadang tidak sampai ke tangan si penerima atau juga bisa sampai ke tangan si penerima tapi data yang diterima tersebut disadap terlebih dahulu tanpa sepengetahuan pengirim maupun penerima itu sendiri. Untuk mengatasi masalah yang ada, peneliti akan membuat suatu aplikasi peningkatan keamanan pesan berbasis android menggunakan algoritma kriptografi RSA yang akan di implementasikan untuk aplikasi pesan pada smartphone android. Aplikasi ini digunakan untuk mengirim dan menerima pesan pada smartphone berbasis android dengan mengamankan atau menyembunyikan pesan asli. Metode yang digunakan Adalah algoritma kriptografi RSA yang menggunakan dua kunci berbeda dalam melakukan enkripsi dan dekripsi yaitu kunci publik untuk enkripsi dan kunci privat untuk dekripsi. Algoritma kriptografi RSA ditambahkan dalam aplikasi ini guna meningkatkan keamanan pesan berbasis android dengan menerapkan algoritma RSA dalam proses mengenkripsikan pesan dengan menggunakan key yang berupa angka-angka yang telah ditentukan pengirim, dan mendekripsikan pesan yang dikirim menjadi pesan asli, sehingga pesan tersebut cukup aman dan tidak akan terbaca oleh pihak yang tidak mempunyai hak atas pesan tersebut.
Cutting cost without compromising quality: Can we deliver ICU care to our poor?
Authors: Faruq Mohammad Omar , Habib Samira Humaira
Published: October 2018

Abstract not availableBangladesh Crit Care J September 2018; 6(2): 62-64
Laparoscopic Appendicectomy in All Benign Pathologies of the Appendix: A retrospective study
Authors: Ratan Md Ezharul Haque , Alam Hasina
Published: October 2018

Background: Acute appendicitis is one of the most common surgical conditions and urgent appendicectomyis recommended and practiced for more than 100 years1,2. McBurney's appendicectomy by an open muscle splitting technique was the gold standard surgical procedure1. Laparoscopic appendicectomy (LA) is gaining popularity since 1987. But this new technique has a longer learning curve and requires expensive equipment (high capital investments).The aim of this study was to ascertain the generalizability of this novel procedure when appendicectomy is indicated.Method: This study was done over a period of six years in BIRDEM. Between March 2010 to February 2016, all consecutive cases of Laparoscopic appendicectomy was selected for the study. Operation was performed under general anaesthesia using standard three puncture technique. After the procedure all resected specimen was sent for histopathology.Result: Laparoscopicappendicectomy was attempted in 113 patients, 57(50.4%) female and 56(49.6%) males. Mean age of the patients were 35.2 years and ranged from 5 to 65 years. Laparoscopicappendicectomy was performed in emergency basis in 102(90%) due to acute appendicitis, gangrenous appendix, perforated appendix or appendicular abscess. Eleven patients (10%) underwent elective surgery due to interval appendicectomy, mucocole of appendix, incidental appendicectomy. The most common indication for laparoscopic appendicectomy in this series was acute appendicitis (62%). Only one patient (<1%) had to be converted to an open appendicectomy due to injury to caecal wall. There was no peri-operative mortality in this series. Hundred and five patients (93%) weredischarged in lessthan 24 hours of surgery and seven (6%) within 48 hours of surgery after removal of intrabdominal drain. Follow-up period was one month to two years.Conclusion: All the advantages of laparoscopy are well applied in laparoscopic appendicectomy. Morbidity, mortality and conversion rate came down to a minimum with time and experience. Hence laparoscopic appendicectomy should be the procedure of choice when appendicectomy in indicated.Bangladesh Crit Care J September 2018; 6(2): 80-83
Is cardiac arrest an inflammatory state? Adding steroid into ACLS guidelines will save more lives?
Authors: Chowdhury Tapati , Nath Arpona Dev , Islam Tasbirul
Published: October 2018

Cardiac arrest is a life-threatening condition with low survival rate. Over the years ACLS guidelines have been developed to reduce cardiac arrest specific mortality rate. In this review article, the authors researched steroid use during and after CPR for determining its effect on survival rate and post cardiac arrest disabilities. Scholarly articles from well-known reputed journals relevant to both cardiac arrest and steroid use since 1960 have been reviewed. This article first examines the question whether cardiac arrest can be considered an inflammatory state. Afterwards, evidence of the beneficial role of steroid use in cardiac arrest and in other cardiac conditions have been outlined. In conclusion, this review paper summarizes any benefits of steroid use in cardiac arrest.Bangladesh Crit Care J September 2018; 6(2): 92-94
Radio Opacity of Honey: A Unique Physical Property with The Potential of A Radio Contrast Media
Authors: Faruq Mohammad Omar , Mokarim Abul , Mursalin Rafael , Susan Md Abu Bin Hasan , Ahmed Saika , Choudhury Ashiq Haider , Ara Gulshan , Faruq Ridwan Naim , Habib Samira Humaira , Karim Md Rezaul , Afrose Momana
Published: October 2018

Background: Honey is known for its various physical properties, chemical contents and as a topical therapeutic agent. However its potential use in diagnostic radiology has not been reported.Aims: To establish radio opacity of honey as its unique physical property, to establish its relationship with other physical properties, chemical contents and to determine if honey has any potential as diagnostic contrast media.Material and Methods: CT scanner was used to calculate radio density in Hounsfield Unit (HU) on six honey samples, honey samples of different dilutions, Iopamidol, 25% glucose and agents containing Calcium, Iron, Magnesium and Potassium. Plain X-ray was obtained on honey samples, honey filled plastic tubes, and honey impregnated cotton gauze. Radio density of honey samples was compared with four selected physical properties of honey.Results: Radio density of six honey samples ranged between 287±3.4 HU and 329±5.3 HU. Radio density of 2% Iopamidol, a commonly used radio contrast agent was 341±8.2 HU. Compared to honey, 25% glucose had low radio density and 15% Potassium chloride had high radio density. Radio density of six honey samples were compared with corresponding density (p=0.0003), specific gravity (p=0.0002), refractive index (p=0.0001) and dynamic viscosity (p=0.10). Plain X-ray images of honey samples showed marked radio opacity.Conclusion: Radio opacity of honey is probably related to its high carbohydrate and potassium content. Honey’s anti-bacterial & healing benefit will offer dual therapeutic and diagnostic advantage with concomitant use as a topical radio contrast agent.Bangladesh Crit Care J September 2018; 6(2): 95-99
Profilistic Study of Bioactivities of Extracts of Gongronema latifolium Incorporated with Alum on some Clinical Bacteria
Authors: Amadi Lawrence O , Ngerebara Nathaniel N , Okafor Chidinma A
Published: October 2018

Profilistic study of bioactivities of aqueous, ethanolic and methanolic leaf extracts of Gongronema latifolium in combination with potassium aluminium sulphate (Alum) against some clinical bacterial pathogens were investigated by disc diffusion (DD) and Agar well diffusion (AWD) methods respectively. The leaf extracts at concentrations of 0.1-0.3g were reconstituted in sterile distilled water as well as 1.0-3.0g of alum prior to application. In-vitro bioactivity of various concentrations of the extracts and in combination with alum were evaluated by measuring diameter of inhibition zones (DIZs) respectively. Methanolic leaf extract (MLE) had the largest mean DIZs of 14.5±0.5 and 11.5±0.0mm on Escherichia coli and Salmonella typhi, with enhanced bioactivity of 19.5±0.7 and 17.5±0.7mm with alum against Bacillus subtilis, Sal. typhi and Pseudomonas aeruginosa by DD and AWD methods respectively. However, aqueous leaf extract (ALE) and ethanolic leaf extract (ELE) and their combinations depicted appreciable antibacterial activity on the pathogens but incomparable to MLE. Generally, there was enhancement of bioactivties with the incorporation of Alum to the leaf extracts (irrespective of solvent of extraction) on a dose response fashion particularly by AWD method. Furthermore, the low MIC values of <0.05 to 0.2mg/ml on the bacteria with MLE and ALE, validates their potency and broad spectrum activity. In contrast, the very large DIZs of Ciprofloxacin (CP) reflects the beneficial impact of purified chemotherapeutics against pathogens. Thus, the improved efficacy of these extracts with alum would justify future application in ethnomedicine as well as in nutraceuticals/pharmaceuticals or in food systems as “green chemicals” or “biopreservatives”.International Current Pharmaceutical Journal, October 2018, 6(12): 92-98
A prolegomenon to the study of pottery stamps from Mes Aynak
Authors: Lerner Judith A.
Published: October 2018

That Afghanistan has been a cultural crossroads is no better demonstrated than by its glyptic art. The designs and styles of the seals used to sign, authenticate and secure documents and packages reflect the artistic and religious traditions of the Hellenistic, Iranian, and Indian worlds. A particular category of seal design is, to my knowledge, known only from impressions on the exterior of clay vessels; they occur at a number of sites in Afghanistan. Their designs differ in style and imagery from the glyptic art of the regions and cultures that produced seals used for authentication purposes and thus suggest that they were carved specifically to mark or decorate ceramics. Recently, a number of potsherds with such seal impressions have been salvaged at the major Buddhist site of Mes Aynak, 40 km southeast of Kabul. Some share motifs with stamped pottery from other sites in Afghanistan, but others are unique. This article is a preliminary exploration of the subject matter and style(s) of the Mes Aynak pottery stamps.
CoQ10 Supplementation in Patients Undergoing IVF-ET: The Relationship with Follicular Fluid Content and Oocyte Maturity
Authors: Giannubilo Stefano , Orlando Patrick , Silvestri Sonia , Cirilli Ilenia , Marcheggiani Fabio , Ciavattini Andrea , Tiano Luca
Published: October 2018

Background: The target of the reduced fecundity with aging is the oocyte. The follicular fluid and its components are strongly linked with the environment of the maturing oocyte. The aim of the present study was to evaluate CoQ10 bioavailability in follicular fluids after oral supplementation and its possible implication in oocyte maturation. Methods: Fifteen female partners of infertile couples, aged 31–46, undergoing IVF-ET and taking 200 mg/day oral CoQ10 were compared to unsupplemented patients. CoQ10 content, its oxidative status and total antioxidant capacity were evaluated also in relation to oocyte maturation indexes. Results: CoQ10 supplementation produced a significant increase in follicular content and a significant improvement of its oxidative status. Follicular fluid total antioxidant capacity highlighted a significant decrease in patients supplemented with CoQ10, specially in women >35 years. CoQ10 supplementation was associated with a significant decrease in total antioxidant capacity of fluid from follicles containing mature oocyte, moreover CoQ10 oxidative status was also significantly reduced but in follicles containing immature oocyte. Conclusions: Our observation leads to the hypothesis that the oral supplementation of CoQ10 may improve follicular fluid oxidative metabolism and oocyte quality, specially in over 35-year-old women.
Dynamic Behavior of a Simple Rolling Seismic Isolator with a Position Restoring Device
Authors: Hong Sung Chul , Hur Deog-Jae
Published: October 2018

Herein, the behavior of a rolling type seismic isolation system with a position restoring device (PRD) is investigated, for alleviating problems such as rapid convergence and position restoration. The equation of motion is derived by modeling the behavior of the seismic isolation system, and the seismic characteristics according to the design variables of the PRD are investigated through numerical analysis. The vibration characteristics of the equation of motion show nonlinearity and depend on different variables. Numerical analysis was performed by using the fourth and fifth order Runge–Kutta method, and the vibration characteristics were analyzed with respect to the design parameters in the rolling type seismic isolation system with PRD, and compared to a model without PRD. In the model with PRD, numerical results show that the vibration suppression capability of the earthquake and the position restoration after disturbance are improved compared to those of the model without PRD. In addition, the rolling type seismic isolation system had nonlinear characteristics at specific frequencies, where the response increases suddenly and harmonics occur. This phenomenon can be controlled by the ratio of mass to stiffness and the damping coefficient, showing that the mount system can be designed to avoid resonance through optimal design.
Identifying Node Importance in a Complex Network Based on Node Bridging Feature
Authors: Jiang Lincheng , Jing Yumei , Hu Shengze , Ge Bin , Xiao Weidong
Published: October 2018

Identifying node importance in complex networks is of great significance to improve the network damage resistance and robustness. In the era of big data, the size of the network is huge and the network structure tends to change dynamically over time. Due to the high complexity, the algorithm based on the global information of the network is not suitable for the analysis of large-scale networks. Taking into account the bridging feature of nodes in the local network, this paper proposes a simple and efficient ranking algorithm to identify node importance in complex networks. In the algorithm, if there are more numbers of node pairs whose shortest paths pass through the target node and there are less numbers of shortest paths in its neighborhood, the bridging function of the node between its neighborhood nodes is more obvious, and its ranking score is also higher. The algorithm takes only local information of the target nodes, thereby greatly improving the efficiency of the algorithm. Experiments performed on real and synthetic networks show that the proposed algorithm is more effective than benchmark algorithms on the evaluation criteria of the maximum connectivity coefficient and the decline rate of network efficiency, no matter in the static or dynamic attack manner. Especially in the initial stage of attack, the advantage is more obvious, which makes the proposed algorithm applicable in the background of limited network attack cost.
Nonlinear Aeroelastic System Identification Based on Neural Network
Authors: Zhang Bo , Han Jinglong , Yun Haiwei , Chen Xiaomao
Published: October 2018

This paper focuses on the nonlinear aeroelastic system identification method based on an artificial neural network (ANN) that uses time-delay and feedback elements. A typical two-dimensional wing section with control surface is modelled to illustrate the proposed identification algorithm. The response of the system, which applies a sine-chirp input signal on the control surface, is computed by time-marching-integration. A time-delay recurrent neural network (TDRNN) is employed and trained to predict the pitch angle of the system. The chirp and sine excitation signals are used to verify the identified system. Estimation results of the trained neural network are compared with numerical simulation values. Two types of structural nonlinearity are studied, cubic-spring and friction. The results indicate that the TDRNN can approach the nonlinear aeroelastic system exactly.
Variations à la Fourier-Weyl-Wigner on Quantizations of the Plane and the Half-Plane
Authors: Bergeron Hervé , Gazeau Jean-Pierre
Published: October 2018

Any quantization maps linearly function on a phase space to symmetric operators in a Hilbert space. Covariant integral quantization combines operator-valued measure with the symmetry group of the phase space. Covariant means that the quantization map intertwines classical (geometric operation) and quantum (unitary transformations) symmetries. Integral means that we use all resources of integral calculus, in order to implement the method when we apply it to singular functions, or distributions, for which the integral calculus is an essential ingredient. We first review this quantization scheme before revisiting the cases where symmetry covariance is described by the Weyl-Heisenberg group and the affine group respectively, and we emphasize the fundamental role played by Fourier transform in both cases. As an original outcome of our generalisations of the Wigner-Weyl transform, we show that many properties of the Weyl integral quantization, commonly viewed as optimal, are actually shared by a large family of integral quantizations.
A Reconfiguration Method for Extracting Maximum Power from Non-Uniform Aging Solar Panels
Authors: Udenze Peter , Hu Yihua , Wen Huiqing , Ye Xianming , Ni Kai
Published: October 2018

Aging affects different photovoltaic (PV) modules in a PV array in a non-uniform way, thereby leading to non-uniform working conditions of the PV modules and resulting in variations in the power outputs of the PV array. In this paper, an algorithm is developed for optimising the electrical configuration of a PV array during the non-uniform aging processes amongst the PV modules. A new PV array reconfiguration method is proposed to maximize the power generation from non-uniformly aged PV arrays through rearrangements of the positions of the PV modules without having to replace the aged PV modules with new ones, thereby saving on maintenance costs. This reconfiguration strategy requires information about the electrical parameters of the PV modules in an array, so as to choose the optimal reconfiguration topology. In this algorithm, the PV modules are sorted iteratively in a hierarchy pattern to reduce the effect of mismatch due to the non-uniform aging processes amongst PV modules. Computer simulation and analysis have been carried out to evaluate the effectiveness of the proposed method for different sizes of non-uniform aged PV arrays (4 × 4, 10 × 10, and 100 × 10 arrays) with MATLAB. The results show an improvement in the power generation from a non-uniformly aged PV array and can be applied to any size of PV array.
Short-Term Load Interval Prediction Using a Deep Belief Network
Authors: Zhang Xiaoyu , Shu Zhe , Wang Rui , Zhang Tao , Zha Yabing
Published: October 2018

In load predication, point-based forecasting methods have been widely applied. However, uncertainties arising in load predication bring significant challenges for such methods. This therefore drives the development of new methods amongst which interval predication is one of the most effective. In this study, a deep belief network-based lower–upper bound estimation (LUBE) approach is proposed, and a genetic algorithm is applied to reinforce the search ability of the LUBE method, instead of simulated an annealing algorithm. The approach is applied to the short-term load prediction on some realistic electricity load data. To demonstrate the effectiveness and efficiency of the proposed method, it is compared with three state-of-the-art methods. Experimental results show that the proposed approach can significantly improve the predication accuracy.
uhuMEB: Design, Construction, and Management Methodology of Minimum Energy Buildings in Subtropical Climates
Authors: Melgar Sergio Gómez , Bohórquez Miguel Ángel Martínez , Márquez José Manuel Andújar
Published: October 2018

Knowledge of buildings′ energy efficiency has advanced thanks to research carried out in recent years. Many of the discoveries in this field have recently been incorporated into mandatory construction regulations for each country. However, not many of the architects and engineers involved in the construction industry clearly know how to achieve those goals in their designs. This document is based on the extensive experience in architectural design, the integration of renewable energies, the energy simulation of buildings and data acquisition, and analysis of the research team involved. It is presented in a practical and holistic approach and focused in subtropical climates. A structured methodology for the proper decision-making process during all the different stages of a minimum energy building (MEB) is likewise presented. The proposed methodology depicted aims at providing architects and engineers with a systematic and orderly step-by-step procedure and incorporates the instrumentation/control and data analysis as essential elements that support the validation of the expected results from the design, the construction, and the operation phase of the building. The paper develops a case study that illustrates the proposed methodology. This new methodology for MEB in subtropical climates constitutes an innovation in this field.
Modeling of Power System Simulation Based on FRTDS
Authors: Zhang Bingda , Hu Ruizhao , Tu Sijia , Zhang Jie , Jin Xianglong , Guan Yun , Zhu Junjie
Published: October 2018

In order to expand the simulation scale of the real-time digital solver based on FPGA (FRTDS, FPGA: field-programmable gate array), the power system modeling process is optimized. The multi-valued parameter method is used to represent the external characteristics of the equipment. The methods of addressing the equivalent admittance and voltage coefficient of the interval unit are discussed in detail. The serial degree of the simulation script is effectively reduced. The disadvantageous effects of asymmetric elements and nonlinear elements on node elimination are analyzed. The elimination order of nodes is determined according to the minimum estimate of the execution time of the simulation script. According to the proposed method to reduce the serial degree and calculation time of the simulation script, software for generating an electromagnetic transient simulation script for power systems is developed. The effectiveness of the software is verified by an example.
Improved Adaptive Backstepping Sliding Mode Control of Static Var Compensator
Authors: Su Qingyu , Dong Fei , Shen Xueqiang
Published: October 2018

The stability of a single machine infinite bus system with a static var compensator is proposed by an improved adaptive backstepping algorithm, which includes error compensation, sliding mode control and a κ -class function. First, storage functions of the control system are constructed based on modified adaptive backstepping sliding mode control and Lyapunov methods. Then, adaptive backstepping method is used to obtain nonlinear controller and parameter adaptation rate for static var compensator system. The results of simulation show that the improved adaptive backstepping sliding mode variable control based on error compensation is effective. Finally, we get a conclusion that the improved method differs from the traditional adaptive backstepping method. The improved adaptive backstepping sliding mode variable control based on error compensation method preserves effective non-linearities and real-time estimation of parameters, and this method provides effective stability and convergence.
Investigating the Enduring Impact of a Community-Based Health Education Program to Promote African American Elders’ Use of Technology Designed to Support Chronic Disease Self-Management
Authors: Senteio Charles R.
Published: October 2018

Elders experience chronic disease disparities and barriers to access technology designed to support recommended self-management behaviors. Elders from racial minority groups are among those who experience particular disparities in chronic disease incidence, outcomes, and barriers to technology use. In order to investigate strategies to address barriers, the study team recruited elder African Americans with diabetes and young adults connected to the elders through naturally occurring familial or social networks. Participants attended a community-based health education session focused on enhancing self-efficacy for recommended self-management and using consumer-oriented technology accessible on their smartphones for self-management support. To assess enduring impact, the study team conducted a pilot study to investigate perceptions and use one month following the health education session. Both elders and young adults offered perspectives on what was effective in teaching elders how to use technology. Both age groups stressed that having patience was crucial, as is providing encouragement for the elders to try tasks on their own. Both elders and young adults also showed a statistically significant increase in aspirations to work together for additional intergenerational health and technology knowledge exchange. Several elder participants continued using technology that they first used during the session. This novel, pilot study describes how to promote self-management and technology use for individuals plagued by persistent chronic disease and technology use disparities.
Change Detection for Building Footprints with Different Levels of Detail Using Combined Shape and Pattern Analysis
Authors: Zhou Xiaodong , Chen Zhe , Zhang Xiang , Ai Tinghua
Published: October 2018

Crowd-sourced geographic information is becoming increasingly available, providing diverse and timely sources for updating existing spatial databases to facilitate urban studies, geoinformatics, and real estate practices. However, the discrepancies between heterogeneous datasets present challenges for automated change detection. In this paper, we identify important measurable factors to account for issues like boundary mismatch, large offset, and discrepancies in the levels of detail between the more current and to-be-updated datasets. These factors are organized into rule sets that include data matching, merge of the many-to-many correspondence, controlled displacement, shape similarity, morphology of difference parts, and the building pattern constraint. We tested our approach against OpenStreetMap and a Dutch topographic dataset (TOP10NL). By removing or adding some components, the results show that our approach (accuracy = 0.90) significantly outperformed a basic geometric method (0.77), commonly used in previous studies, implying a more reliable change detection in realistic update scenarios. We further found that distinguishing between small and large buildings was a useful heuristic in creating the rules.
Chronic Upregulation of Cleaved-Caspase-3 Associated with Chronic Myelin Pathology and Microvascular Reorganization in the Thalamus after Traumatic Brain Injury in Rats
Authors: Glushakov Andriy O. , Glushakova Olena Y. , Korol Tetyana Y. , Acosta Sandra A. , Borlongan Cesar V. , Valadka Alex B. , Hayes Ronald L. , Glushakov Alexander V.
Published: October 2018

Traumatic brain injury (TBI) is associated with long-term disabilities and devastating chronic neurological complications including problems with cognition, motor function, sensory processing, as well as behavioral deficits and mental health problems such as anxiety, depression, personality change and social unsuitability. Clinical data suggest that disruption of the thalamo-cortical system including anatomical and metabolic changes in the thalamus following TBI might be responsible for some chronic neurological deficits following brain trauma. Detailed mechanisms of these pathological processes are not completely understood. The goal of this study was to evaluate changes in the thalamus following TBI focusing on cleaved-caspase-3, a specific effector of caspase pathway activation and myelin and microvascular pathologies using immuno- and histochemistry at different time points from 24 h to 3 months after controlled cortical impact (CCI) in adult Sprague-Dawley rats. Significant increases in cleaved-caspase-3 immunoreactivity in the thalamus were observed starting one month and persisting for at least three months following experimental TBI. Further, the study demonstrated an association of cleaved-caspase-3 with the demyelination of neuronal processes and tissue degeneration in the gray matter in the thalamus, as reflected in alterations of myelinated fiber integrity (luxol fast blue) and decreases in myelin basic protein (MBP) immunoreactivity. The immunofluorescent counterstaining of cleaved-caspase-3 with endothelial barrier antigen (EBA), a marker of blood-brain barrier, revealed limited direct and indirect associations of cleaved caspase-3 with blood-brain barrier damage. These results demonstrate for the first time a significant chronic upregulation of cleaved-caspase-3 in selected thalamic regions associated with cortical regions directly affected by CCI injury. Further, our study is also the first to report that significant upregulation of cleaved-caspase-3 in selected ipsilateral thalamic regions is associated with microvascular reorganization reflected in the significant increases in the number of microvessels with blood-brain barrier alterations detected by EBA staining. These findings provide new insights into potential mechanisms of TBI cell death involving chronic activation of caspase-3 associated with disrupted cortico-thalamic and thalamo-cortical connectivity. Moreover, this study offers the initial evidence that this upregulation of activated caspase-3, delayed degeneration of myelinated nerve fibers and microvascular reorganization with impaired blood-brain barrier integrity in the thalamus might represent reciprocal pathological processes affecting neuronal networks and brain function at the chronic stages of TBI.
Relationship between the Regulation of Caspase-8-Mediated Apoptosis and Radioresistance in Human THP-1-Derived Macrophages
Authors: Yoshino Hironori , Konno Haruka , Ogura Koya , Sato Yoshiaki , Kashiwakura Ikuo
Published: October 2018

Radiosensitivity varies depending on the cell type; highly differentiated cells typically exhibit greater radioresistance. We recently demonstrated that human macrophages derived from THP-1 monocytic cells, which lack TP53, are highly resistant to radiation-induced apoptosis compared with undifferentiated THP-1 cells. However, the mechanisms by which THP-1 cells acquire radioresistance during differentiation remain unknown. Herein, we investigated the mechanisms by which THP-1-derived macrophages develop p53-independent radioresistance by analyzing DNA damage responses and apoptotic pathways. Analysis of γ-H2AX foci, which indicates the formation of DNA double-strand breaks (DSB), suggested that a capacity to repair DSB of macrophages is comparable to that of radiosensitive THP-1 cells. Furthermore, treatment with inhibitors against DSB repair-related proteins failed to enhance radiation-induced apoptosis in THP-1-derrived macrophages. Analysis of the apoptotic pathways showed that radiosensitive THP-1 cells undergo apoptosis through the caspase-8/caspase-3 cascade after irradiation, whereas this was not observed in the macrophages. Caspase-8 protein expression was lower in macrophages than in THP-1 cells, whereas mRNA expressions were comparable between both cell types. Co-treatment with a proteasome inhibitor and ionizing radiation effectively induced apoptosis in macrophages in a caspase-8-dependent manner. Results suggest that the regulation of caspase-8-mediated apoptosis during differentiation plays a role in the p53-independent radioresistance of THP-1-derived macrophages.
Influence of Dental Prosthesis and Restorative Materials Interface on Oral Biofilms
Authors: Hao Yu , Huang Xiaoyu , Zhou Xuedong , Li Mingyun , Ren Biao , Peng Xian , Cheng Lei
Published: October 2018

Oral biofilms attach onto both teeth surfaces and dental material surfaces in oral cavities. In the meantime, oral biofilms are not only the pathogenesis of dental caries and periodontitis, but also secondary caries and peri-implantitis, which would lead to the failure of clinical treatments. The material surfaces exposed to oral conditions can influence pellicle coating, initial bacterial adhesion, and biofilm formation, due to their specific physical and chemical characteristics. To define the effect of physical and chemical characteristics of dental prosthesis and restorative material on oral biofilms, we discuss resin-based composites, glass ionomer cements, amalgams, dental alloys, ceramic, and dental implant material surface properties. In conclusion, each particular chemical composition (organic matrix, inorganic filler, fluoride, and various metallic ions) can enhance or inhibit biofilm formation. Irregular topography and rough surfaces provide favorable interface for bacterial colonization, protecting bacteria against shear forces during their initial reversible binding and biofilm formation. Moreover, the surface free energy, hydrophobicity, and surface-coating techniques, also have a significant influence on oral biofilms. However, controversies still exist in the current research for the different methods and models applied. In addition, more in situ studies are needed to clarify the role and mechanism of each surface parameter on oral biofilm development.
Ion Channels in Pulmonary Hypertension: A Therapeutic Interest?
Authors: Lambert Mélanie , Capuano Véronique , Olschewski Andrea , Sabourin Jessica , Nagaraj Chandran , Girerd Barbara , Weatherald Jason , Humbert Marc , Antigny Fabrice
Published: October 2018

Pulmonary arterial hypertension (PAH) is a multifactorial and severe disease without curative therapies. PAH pathobiology involves altered pulmonary arterial tone, endothelial dysfunction, distal pulmonary vessel remodeling, and inflammation, which could all depend on ion channel activities (K+, Ca2+, Na+ and Cl−). This review focuses on ion channels in the pulmonary vasculature and discusses their pathophysiological contribution to PAH as well as their therapeutic potential in PAH.
Acid Sphingomyelinase Inhibition Stabilizes Hepatic Ceramide Content and Improves Hepatic Biotransformation Capacity in a Murine Model of Polymicrobial Sepsis
Authors: Chung Ha-Yeun , Witt C. Julius , Hurtado-Oliveros Jorge , Wickel Jonathan , Gräler Markus H. , Lupp Amelie , Claus Ralf A.
Published: October 2018

Liver dysfunction during sepsis is an independent risk factor leading to increased mortality rates. Specifically, dysregulation of hepatic biotransformation capacity, especially of the cytochrome P450 (CYP) system, represents an important distress factor during host response. The activity of the conserved stress enzyme sphingomyelin phosphodiesterase 1 (SMPD1) has been shown to be elevated in sepsis patients, allowing for risk stratification. Therefore, the aim of the present study was to investigate whether SMPD1 activity has an impact on expression and activity of different hepatic CYP enzymes using an animal model of polymicrobial sepsis. Polymicrobial sepsis was induced in SMPD1 wild-type and heterozygous mice and hepatic ceramide content as well as CYP mRNA, protein expression and enzyme activities were assessed at two different time points, at 24 h, representing the acute phase, and at 28 days, representing the post-acute phase of host response. In the acute phase of sepsis, SMPD1+/+ mice showed an increased hepatic C16- as well as C18-ceramide content. In addition, a downregulation of CYP expression and activities was detected. In SMPD1+/− mice, however, no noticeable changes of ceramide content and CYP expression and activities during sepsis could be observed. After 28 days, CYP expression and activities were normalized again in all study groups, whereas mRNA expression remained downregulated in SMPD+/+ animals. In conclusion, partial genetic inhibition of SMPD1 stabilizes hepatic ceramide content and improves hepatic monooxygenase function in the acute phase of polymicrobial sepsis. Since we were also able to show that the functional inhibitor of SMPD1, desipramine, ameliorates downregulation of CYP mRNA expression and activities in the acute phase of sepsis in wild-type mice, SMPD1 might be an interesting pharmacological target, which should be further investigated.
BGJ398, A Pan-FGFR Inhibitor, Overcomes Paclitaxel Resistance in Urothelial Carcinoma with FGFR1 Overexpression
Authors: Kim Se Hyun , Ryu Haram , Ock Chan-Young , Suh Koung Jin , Lee Ji Yun , Kim Ji-Won , Lee Jeong-Ok , Kim Jin Won , Kim Yu Jung , Lee Keun-Wook , Bang Soo-Mee , Kim Jee Hyun , Lee Jong Seok , Ahn Joong Bae , Kim Kui-Jin , Rha Sun Young
Published: October 2018

Paclitaxel (PTX) is commonly used to treat urothelial carcinoma (UC) after platinum-based chemotherapy has failed. However, single-agent taxane therapy is not sufficient to inhibit tumor progression and drug resistance in advanced UC. Epithelial-to-mesenchymal transition (EMT) induced by fibroblast growth factor receptor (FGFR)1 signaling has been proposed as a mechanism of PTX resistance, but it is unclear whether this can be overcome by FGFR1 inhibition. The present study investigated whether FGFR1 overexpression contributes to PTX resistance and whether FGFR inhibition can enhance PTX efficacy in UC. The effects of PTX combined with the FGFR inhibitor BGJ398 were evaluated in UC cell lines by flow cytometry; Western blot analysis; cell viability, migration, and colony forming assays; and RNA interference. PTX+BGJ398 induced cell cycle arrest and apoptosis in UC cells with mesenchymal characteristics was accompanied by downregulation of cyclin D1 protein and upregulation of gamma-histone 2A family member X and cleaved poly(ADP-ribose) polymerase. Additionally, PTX+BGJ398 synergistically suppressed UC cell migration and colony formation via regulation of EMT-associated factors, while FGFR1 knockdown enhanced the antitumor effect of PTX. These findings provide a basis for development of effective strategies for overcoming PTX resistance in UC through inhibition of FGFR1 signaling.