bluuebunny/crossref_metadata_2025 huggingface dataset:
Media Monitoring Analysis of Government Image in Infrastructure Development in Indonesia
Authors: Hutagalung Simon Sumanjoyo , Kartika Tina , Suciska Wulan
Published: July 2023

The massive infrastructure development program during president Jokowi's administration will always produce a variety of different perceptions in the public area. Public perception will be built differently and form the image of the government in the scope of the implementation of the program and can be the material of preparing a government communication plan to the public. Research objectives in this article; Analyze the dynamics of the government's image in the topic of infrastructure development on social and non-media sosial. More specifically, several points of purpose are to be achieved as follows: (a). The amount of discussion volume on the topic of infrastructure development, (b). The dominant parties discuss and respond to the topic of infrastructure development, (c). Dynamics of public sentiment in discussions with the topic of infrastructure development. The research method is done with media monitoring analysis that starts with a search profile and searches for terms or keywords. Furthermore, data mining using the Brand24 Media Monitoring application using the keywords Infrastructure Development and Infrastructure Projects. The data mining process is carried out in a span of 90 days, from Aug 16, 2021 to Nov 14, 2021. Data analysis is done simultaneously with the Brand24 and Microsoft Excel applications for data rechecking and confirmation of the data to be analyzed. The results of the analysis concluded; On the topic of infrastructure development, the volume of mentions was obtained by 13 thousand times, of which the most dominant media was non-media sosial with the composition of news agencies (5433) and the web (4435), while the media sosial area represented by several applications, forums, blogs, videos youtube) and podcasts had a smaller portion of the topic.
Indigenous Community-Based Cultural Tourism Communication
Authors: Andung Petrus Ana , Letuna Mariana A. Noya , Nara Maria Yulita , Leuape Emanuel Sowe
Published: July 2023

Kampung Adat Ratenggaro (KAR) is a unique cultural tourism destination in Southwest Sumba Regency (SBD). This traditional village, which is located in the village of Maliti Bondo Ate, has traditional house buildings with quite unique shapes, historical tours in the form of stone graves, and Ratenggaro Beach natural attractions. This attraction makes many tourists come to visit the Ratenggaro Traditional Village. KAR tourism is now fully managed by indigenous peoples. This study aims to map the tourism communication model developed through the active involvement of indigenous peoples. This study is qualitative research using a case study approach. The study shows that the tourist destinations contained in the KAR highlighted the concept of tourism based on local branding by utilizing the local wisdom of the local community. Meanwhile, the involvement of local communities in KAR's tourism activities can be seen starting from tourism planning, and tourism promotion, to evaluation. The tourism communication model developed by KAR is based on indigenous peoples by placing the role of ndorumbaha (local tour guide) as a central figure in KAR tourism. Ndorumbaha is an essential figure in conducting KAR tourism communication. The ndorumbaha is tasked with conveying various information about what and how each KAR tourist attraction is to every visitor, both domestic and foreign. This tourism communication model in turn will be able to guarantee the creation of sustainable tourism with prominent local branding.
PELATIHAN PEMBUATAN UNIT PENGOLAHAN AIR GAMBUT BAGI MASYARAKAT DI KELURAHAN KALAMPANGAN, KOTA PALANGKA RAYA
Authors: Agnestisia Retno , Iqbal Rendy Muhamad , Damsyik Akhmad , Nareyasa Wayan Adhi
Published: July 2023

Air merupakan kebutuhan paling dasar manusia untuk menunjang kehidupan sehari-hari. Persediaan air bersih merupakan salah satu masalah yang dihadapi oleh masyarakat di Kelurahan Kalampangan, Kecamatan Sebangau, Kota Palangka Raya. Masyarakat setempat yang tidak mendapatkan pelayanan air bersih umumnya menggunakan air gambut sebagai sumber air karena dinilai lebih ekonomis dan melimpah. Namun demikian, air gambut yang digunakan tidak memenuhi persyaratan sebagai air bersih. Oleh karena itu, muncullah sebuah gagasan untuk memberikan pelatihan tentang pembuatan unit pengolahan air gambut kepada masyarakat setempat. Metode yang dipilih untuk pengolahan air gambut terdiri dari beberapa tahapan, yaitu netralisasi, koagulasi-flokulasi, sedimentasi, dan filtrasi. Hasil kegiatan menunjukkan bahwa unit pengolahan air gambut yang didemokan dapat dimanfaatkan untuk mengolah air gambut menjadi air yang layak untuk digunakan pada kehidupan sehari-hari. Kegiatan ini diharapkan dapat meningkatkan kualitas hidup masyarakat setempat terutama dari sisi pemenuhan akan kebutuhan air bersih.

Kata kunci: air bersih, pengolahan air, air gambut, Palangka Raya

ABSTRACT

The most fundamental requirement for humans to sustain daily life is water. The supply of clean water is one of the problems faced by the community in Kelampangan Village, Sebangau District, Palangka Raya City. Local people who do not get clean water services generally use peat water as a water source because it is considered more economical and abundant. However, the peat water does not qualify as clean water. Therefore, an idea emerged to provide socialization about constructing a peat water treatment unit for local communities. The method chosen to treat peat water consists of four stages, i.e., neutralization, coagulation-flocculation, sedimentation, and filtration. The results show that the peat water treatment unit demonstrated can be used to treat peat water into water suitable for use in daily life. This activity is expected to improve their quality of life, especially to fulfill the clean water requirement.

Keywords: clean water, water treatment, peat water, Palangka Raya
PEMANFAATAN PEPAYA MENTAH MENJADI STIK PEPAYA GUNA MENINGKATKAN SUMBER DAYA ALAM, MASYARAKAT DUKUH NGLUMPANG DESA PANGKAL KECAMATAN SAWOO
Authors: Kurniawati Ivtin , Mustahpiroh Khusnul , Faizin Moh. , Diana Lindri Fransiska , Anggraini Lutfia Sita
Published: July 2023

Pengenalan produk olahan pepaya mentah menjadi stik pepaya merupakan kegiatan pengabdian untuk masyarakat yang memiliki tujuan memberikan solusi dari permasalahan yang dihadapi oleh masyarakat khususnya ibu rumah tangga dalam menghasilkan olahan produk kreatif. Dengan menggali potensi sumber daya alam yang ada dapat bermanfaat dalam meningkatkan usaha sampingan selain bertani maupun pekerjaan lainnya. Maka dari itu, sangat dibutuhkan pengenalan inovasi pengolahan pada produk. Setelah dianalisis dari masalah tersebut, maka model pelaksanaan kegiatan mencangkup sosialisasi yang dilaksanakan dengan mengenalkan produk kepada anak-anak dan ibu-ibu dusun Nglumpang secara langsung. Dilanjutkan dengan tanya jawab terkait cara pembuatan, alat dan bahan serta diskusi lain yang berhubungan dengan proses pembuatan stik pepaya. Hasil yang diharapkan dari dilaksanakannya kegiatan yaitu masyarakat dapat meningkatkan pengetahuan tentang manfaat pepaya sebagai salah satu pangan lokal yang dapat diolah menjadi beraneka camilan yang bernilai ekonomi tinggi, produk camilan yang menarik dan diminati banyak orang, sehingga layak untuk dipasarkan dan menjadi usaha sampingan.

Kata kunci: masyarakat, sosialisasi, olahan, pepaya

ABSTRACT

The introduction of processed raw papaya products into papaya sticks is a community service activity that aims to provide solutions to the problems faced by the community, especially housewives in producing processed creative products. By exploring the potential of existing natural resources, it can be useful in increasing side businesses besides farming and other jobs. Therefore, it is very necessary to introduce processing innovations in products. After analyzing the problem, the model for implementing activities includes socialization which is carried out by introducing the product to the children and mothers of the Nglumpang hamlet directly. Followed by questions and answers related to how to make, tools and materials as well as other discussions related to the process of making papaya sticks. The expected result from the implementation of the activity is that the community can increase knowledge about the benefits of papaya as a local food that can be processed into various snacks that have high economic value, snack products that are attractive and in demand by many people, so that they are worthy of being marketed and becoming a side business.

Keywords: society, socialization, processing, papaya
TEKNOLOGI BIOPORI: SOLUSI KAWASAN RAWAN GENANGAN DAN EDUWISATA DI DESA WISATA ALAM SUNGAI MESJID KOTA DUMAI
Authors: Martina Atria , Lestari Wahyu , Linda Tetty Marta , Wahibah Ninik Nihayatul , Julita Vanda Julita
Published: July 2023

Desa Sungai Mesjid memiliki keindahan alam dan budaya Melayu yang masih terjaga. Pembentukan Kelompok Sadar Wisata (POKDARWIS) Alam Sungai Mesjid membuat potensi Desa sebagai desa ekowisata mulai dikembangkan untuk meningkatkan perekonomian masyarakat. Peningkatan pembangunan di Dumai membuat berkurangnya daerah resapan air serta penanggulangan sampah yang kurang baik turut memberi dampak tergenangnya beberapa daerah di Desa ini. Masyarakat berkeinginan mewujudkan desa yang hijau minim dari sampah dan genangan air jika hujan namun terkendala dengan pengetahuan dan biaya. Edukasi dan pemberdayaan masyarakat dengan pembuatan biopori sebagai resapan air dan penghasil kompos akan dapat mengurangi genangan air hujan dan mengatasi sampah organik. Metode penerapan kegiatan berupa presentasi, diskusi kelompok, praktek pembuatan lubang biopori, pemberian peralatan serta monitoring keberlanjutan pasca kegiatan. Selama kegiatan pelatihan terlihat adanya motivasi dan kesadaran masyarakat akan manfaat biopori. Pembuatan biopori tetap berlanjut pasca kegiatan yang dilakukan oleh masyarakat secara mandiri dan menjadikan teknologi pembuatan biopori sebagai salah satu paket eduwisata Desa Alam Sungai Masjid, sebagai upaya edukasi kepada masyarakat luas dan daya tarik wisata.

Kata kunci: biopori, desa wisata, eduwisata, genangan, kompos

Abstract

Sungai Mesjid has wonderful scenery and Malay culture that are still preserved. The development of the Alam Sungai Mesjid Tourism Awareness Community (POKDARWIS) made the potential of the village as an ecotourism in order to improve the community’s economy during the Covid-19 pandemic. The increase in recent development in Dumai has reduced water catchment areas and poor waste management, and also impacted the inundation of several areas in this village. The community wants to create a green village where is minimal from garbage and puddles when rain falls, but it is constrained by knowledge and costs. Education and empowerment of society by making biopore as a water catchment and producing compost will be able to reduce rainwater puddles and overcome organic waste. The method of implementing the activity is a presentation, group discussion, practice of making biopore holes, provision of equipment and post-activity monitoring of sustainability. During the training activities, it was seen there were motivation and public awareness of benefits biopore. The development of biopore continues after the activities carried out by the community independently and makes biopore technology as one of the edutourism packages of Alam Sungai Masjid Village, as an educational effort to wider community and tourist attraction.

Keywords: biopore, tourism village, edutourism, puddle, compost
Algoritma Haversine pada Sistem Informasi Geografis: Tinjauan Literatur Sistematis
Authors: Hasanah Mau'idzoh , Suharso Aries
Published: July 2023

Along with the times, more and more developments are being carried out, starting from the construction of buildings, housing, supermalls, hotels, and so on. More and more buildings cause the order on the earth's surface to change and make more and more roads. Roads are becoming more and more narrow, making it difficult for people to travel to a destination, especially in foreign areas. Departing from this problem, there is anxiety among the people who do not know the distance to their destination, making it difficult to go anywhere. However, with the presence of increasingly developing technology, it can be used as a practical solution to this problem. The technology that can be utilized is called a Geographic Information System (GIS). With the help of the haversine algorithm for distance calculation, GIS provides geographic information on the earth's surface in the form of a system. This review aims to present a comprehensive picture of the accuracy of the haversine algorithm in geographic information systems that is useful for helping these community problems
Rancang Bangun Aplikasi Operasional Departemen Finance Studi Kasus PT. Maja Kerta Wangi
Authors: Budiman Budiman , Rakhman Alamsyah Rd. Yadi , Fauzi Ramadhan Ahmad
Published: July 2023

The large number of travel document transactions, credit cards, and invoice payments is a problem that complicates the finance department. In actual work, many travel documents are printed more than once, which burdens printing costs, loads the capacity of archive space which must be stored for five years, and requires destroying documents whose expired shelf life. The verification and validation process carried out by officers experienced problems because the system had not been integrated, so travel documents became past due and caused delays in supplier payments. The design and construction of operational applications for the finance department aim to digitize and integrate operational and financial processes to become combined, especially in managing travel documents, debt cards, and bill payments. The software development method used in this study is the waterfall which consists of the stages of analysis, design, implementation, and testing. Based on the testing results, the application shows that the application can assist in the operational process of the financial section, especially the data collection of travel documents into debt cards, then processing and paying bills based on invoices.
ANALISIS DAN PERANCANGAN SISTEM PENJUALAN PADA TOKO XYZ BERBASIS WEB DAN MOBILE MENGGUNAKAN UML
Authors: Imannudin Akbar  , Budiman  , Zatin Niqotaini  , Ari Rizki Fauzi
Published: July 2023

Technological advancements have a significant impact on businesses, particularly in the realm of sales. XYZ store currently relies on manual business processes, leading to a non-computerized and uncoordinated sales system. Consequently, there is a need for an innovative new business model that utilizes web and mobile-based systems. In this study, Rosa A.S.'s Prototype research method is employed to design the sales system using UML notation in the form of diagrams. The designed sales system caters to three user categories: customers accessing the mobile platform, store clerks, and store owners accessing the website platform. The study's outcomes consist of an analysis report and the design of a web- and mobile-based sales information system (mock-up) for XYZ store. The aim is to create a user-friendly interface that facilitates understanding for the sellers, making sales transactions more efficient. Moreover, the system aims to enhance convenience for customers and buyers, enabling them to conduct transactions and access product information from any location
Analisis Sistem Informasi Akademik Menggunakan Metode FAST Pada SDIT Al-Qudwah Pangkalpinang
Authors: Sujono
Published: July 2023

The Academic System is the management of academic data in an educational institution including at SDIT Al-Qudwah Pangkalpinang, which consists of managing student data, schedule data, attendance data, and grades data. However, management is currently still carried out manually without using technology. The downside is that the manual method is vulnerable to human error, the amount of time and effort needed to record and calculate so that data collection becomes less efficient and accurate, and it is prone to losing data values ​​that have been recorded. Therefore it is necessary to build a web-based information system that can manage academic data in a modern way so that time efficiency and data accuracy can be increased. To design, analyze and develop the system, the writers use the FAST method and UML tools. Using this web based academic information system can overcome the weaknesses faced by SDIT Al-Qudwah Pangkalpinang
SISTEM PENDETEKSI KEBOCORAN TABUNG GAS ELPIJI (LPG) BERBASIS NODEMCU DAN TELEGRAM
Authors: Alamsyah Nur , Nurlaela Safitri
Published: July 2023

The increasing population level of society makes the level of public consumption of natural resources also increase, in this case the increase occurs in the use of LPG (Liquefied Petroleum Gas) fuel. With the increasing use of LPG fuel, it is possible for fires to occur caused by LPG gas leaks. However, not all LPG gas cylinder providers provide additional safety systems on the LPG cylinders they sell. So an LPG gas leak detection device and a system that can provide information in the event of an LPG cylinder leak are needed. For this reason, an LPG gas leak detection device is made using a Telegram notification system, and an MQ-2 Sensor that can detect LPG gas and provide an alarm sound and LED indicator and LCD display display. so that it can provide a warning if the owner of the LPG cylinder is outside the house. All of these components are controlled using a Nodemcu Microcontroller. This tool has the advantage of being easy to use and compatible with all Telegram-based communication devices.
IMPLEMENTASI SISTEM MONITORING PRODUKSI ENERGI PLTS BERBASIS PROTOKOL MODBUS RTU DAN MODBUS TCP
Authors: Fransiscus Xaverius Ariwibisono  , Widodo Pudji Muljanto
Published: July 2023

The use of renewable energy sources is currently starting to grow rapidly in line with the need for environmentally friendly power sources. Solar power plants are a choice of solutions for the community, especially those in areas that have not been reached by the electricity grid. The production of the resulting electrical energy is highly dependent on the capacity of the installed solar panels. In order to monitor solar power plants electricity production and usage load, a facility is needed that can provide real-time information. Besides that, it can easily be accessed remotely by utilizing a network that uses the TCP/IP protocol. The problem that arises then is that the sensor data obtained from the readings must comply with the standard parameters that apply to all sensor equipment. The Modbus RTU and Modbus TCP protocols are the right choice to answer this problem. This research will discuss the implementation of the Modbus RTU/TCP protocol within the scope of solar power plants. Thus, solar power plants electrical energy monitoring system allows it to be applied to networks that are located far from the control or monitoring center.
Study on gametophyte cultivation and bioactive evaluation on biomass of silver moss Bryum argenteum Hedw.
Authors: Tan Tran-Quoc , My-Duyen Nguyen-Thi , Dat Tran-Quoc , Diem-Phuong Quach-Ngo
Published: July 2023

Silver moss has long been used as a source of medicinal herbs in several remedies by some tribes around the world. Silver moss was grown to get pure biomass to study the biological activities and active substances. First, the protonema filaments were made to multiply shoots as gametophytes by adding the plant growth regulator 6-benzylaminopurine (BA). Afterward, gametophytes' growth was tested under different conditions including different mineral mediums, types and concentrations of sugar, cultivation types and kinds of light to obtain more biomass. Finally, the n-hexane, ethyl acetate and ethanol fraction residues of in vitro and natural biomass were evaluated for DPPH free radical scavenging and tyrosinase inhibition. On the culture medium (1/2 MS), adding 1.0 mg/L BA made the gametophyte develop well and increased the number of shoots collected the most. Silver moss increased biomass accumulation best on 1/2 BCD mineral base, compared with other conditions with the same positive effect on biomass increase. The in vitro biomass extract has a high potential for bioactivity, as the ethyl acetate fraction has DPPH scavenging activity similar to the wild type. Also, the n-hexane fraction of in vitro biomass is the most effective tyrosinase inhibitor of all the fractions examined.
Comparing of antioxidant ability, α-glucosidase inhibition and cytotoxicity of three fruiting body shapes of Ganoderma lingzhi
Authors: Phuong Lam-Huy , Dai Cao-Minh , Diem-Phuong Quach-Ngo , Tan Tran-Quoc
Published: July 2023

In the process of artificial culture, Ganoderma mushrooms will appear with several different shapes of fruiting bodies, even though they share the same species. The differences in shape can influence and create differences in bioactivity and active ingredients. This study looked at the biological activities of ethanol crude extracts from three shape kinds of fruiting bodies of Ganoderma lingzhi mushroom and herb tablets made from kidney-shaped fruiting body including antioxidant, α-glucosidase inhibition and cytotoxic activity in some cell lines. Besides, the content of ganoderic acid A was also evaluated among the tested samples. The results showed that different shapes of G. lingzhi could possess differences in bioactivities. The shapes with elongated fruiting body stem including antler- and intermediate form, have better antioxidant and α-glucosidase inhibitory capacity than the common kidney shape. Furthermore, the antler and intermediate forms' cytotoxic activity against cell lines including fibroblast, NCI H469 and Hep G2, were higher than the kidney-shaped mushroom extracts. Similarly, the results of ganoderic acid A content from the extracts of antler- and intermediate form samples were also higher than that of the other form. Meanwhile, the herb tablets had the same pattern to the kidney-shaped extract in several activities. The ganoderic acid A content of the tablet sample was lower than that of three samples extracted from different mushroom shapes. Interestingly, the tablets showed the best-reducing power among the investigated samples.
Perilla frutescens (L.) Britt extract alleviating acute liver injury in mice induced by thioacetamide
Authors: Dang Minh Thanh , Duong Thi Ngoc Le , To Quoc Hoa , Le Van Trinh , Huynh Ngoc Trinh , Truong Hai Nhung
Published: July 2023

Liver fibrosis is a significant public health concern and is one of the leading causes of death worldwide (2019). Perilla (Perilla frutescens (L.) Britt - PF) is a herb with potent anti-inflammatory and antioxidant properties extensively employed in traditional medicine. This study evaluated the hepatoprotective effects of perilla extract on mice with liver damage caused by Thioacetamide (TAA). Mice were induced liver damage by TAA and given perilla extract, then liver damage assessed through indicators: liver function (albumin index), liver enzymes (ALT, AST indices), liver necrosis and fibrosis by histological staining (H&E and Sirius red staining) and expression levels of genes related to fibrogenesis, antioxidant system and inflammation. Acute liver injury mice treated with PF extract decreased WBC count, biochemical indices: AST, ALT; improved serum ALB level; reduced percentage of necrotic and fibrotic area; diminished expression of myofibroblast marker α-sma and inflammatory cytokine IL6; upregulated expression of gene related to antioxidant system GPx, bax. The result suggested that TAA 150 mg/kg caused hepatotoxicity and 100 mg/kg Perilla Frutescens (L.) has a hepaprotective effect that can attenuate liver damage.
Nucleobase catalysts for the enzymatic activation of 8-oxoguanine DNA glycosylase 1
Authors: Hank Emily C. , D'Arcy-Evans Nicholas , Wallner Olov , Ortis Florian , Meng Liuzhen , Calvo Patricia , Scaletti Emma Rose , Kosenina Sara , Dawson Holly , Stewart Josephine , Dickey Adam , Astorga Mikhael E. , Wiita Elisée , Varga Marek , Homan Evert J , Jemth Ann-Sofie , Benítez-Buelga Carlos , Scobie Martin , Helleday Thomas , Stenmark Pål , de Vega Miguel , Michel Maurice
Published: July 2023

Bifunctional DNA glycosylases employ an active site lysine or the N-terminus to form a Schiff base with the abasic site base excision repair intermediate. For the 8-oxoguanine DNA glycosylase 1 (OGG1), cleaving this reversible structure is the rate-determining step in the initiation of 8-oxoguanine (8-oxoG) repair in DNA. Evolution has led OGG1 to use a productassisted catalysis approach, where the excised 8-oxoG acts as a Brønsted base for cleavage of a Schiff base intermediate. However, the physicochemical properties of 8-oxoG significantly limit the inherent enzymatic turnover. We hypothesized that chemical synthesis of purine analogues enables access to complex structures that are suitable as product-like catalysts. Here, the nucleobase landscape is profiled for its potential to increase OGG1 Schiff base cleavage. 8-Substituted 6-thioguanines emerge as potent scaffolds enabling OGG1 to cleave abasic sites opposite any canonical nucleobase by β-elimination. This effectively broadens the enzymatic substrate scope of OGG1, shaping a complete, artificial AP-lyase function. In addition, a second class of activators, 6-substituted pyrazolo-[3,4-d]-pyrimidines, stimulate OGG1 function at high pH, while thioguanines govern enzymatic control at acidic pH. This enables up to 20-fold increased enzyme turnover and a de novo OGG1 β- elimination in conditions commonly not tolerated. This allows for the development of activators applicable in distinct pH environments of different cellular compartments.
Fabrication of Ceramic Matrix Composites via Cold Sintering Process
Authors: Sun Hongtao , Zhang Juchen
Published: July 2023

Integrating polymers into ceramics is very intriguing since many new interesting characteristics can be introduced into the system while modifying the flaws of ceramic materials. However, the fabrication of ceramic-polymer composites, particularly polymer-in-ceramic matrix composites, has always been a problem due to the substantial temperature disparity between the melting points of polymers and ceramics. Cold sintering is an emerging technology that applies uniaxial pressure and a transient solvent to reduce the ceramic sintering temperature by approximately an order magnitude, down to about 100-200oC, which is significantly lower than typical sintering temperatures (e.g., 1000-1500oC) by using traditional sintering methods, making it very ideal for combining ceramics and polymers. This review delves into the current status, understanding, and application of cold co-sintering, examining various examples of ceramics and polymers employed. By adjusting the polymer types and percentages in the composite, quality control and surface engineering can be achieved. Moreover, the potential of cold sintering remains largely unexplored, and we discuss its outlooks and future implications for ceramic-polymer composites, including considerations for scale-up possibilities and recycling capabilities for an eco-manufacturing process. As our understanding of the cold sintering process continues to advance, it promises to unlock significant breakthroughs in producing ceramic-polymer composites in the future.
Degradable Latexes by Nitroxide-Mediated Aqueous Seeded Emulsion Copolymerization using Thionolactones
Authors: Lages Maëlle , Gil Noémie , Galanopoulo Paul , Mougin Julie , Lefay Catherine , Guillaneuf Yohann , Lansalot Muriel , D'Agosto Franck , Nicolas Julien
Published: July 2023

Thiocarbonyl addition-ring-opening (TARO) polymerization of thionolactones offers the unique opportunity to incorporate thioester functions into vinyl polymer backbones via a radical mechanism. Recently, successful synthesis of degradable vinyl copolymer latexes based on dibenzo[c,e]oxepane-5-thione (DOT) has been reported by free-radical polymerization (FRP) in emulsion and aqueous polymerization-induced self-assembly (PISA). Herein, to combine a controlled radical polymerization process with the avoidance of preliminary synthesis, we performed the aqueous nitroxide-mediated copolymerization (NMP) of DOT and n-butyl acrylate (nBA) or styrene (S) via a two-step ab initio emulsion process. nBA was first polymerized in water in the presence of the BlocBuilder alkoxyamine and DOWFAX 8390 as the surfactant to generate a stable aqueous suspension of living seeds of low molar mass PnBA-SG1. Seeded emulsion copolymerization was then performed via chain extension of the seeds at 110 °C for 8 h by a mixture of DOT and nBA (or S), leading to stable latexes of average diameters ranging from 120 to 320 nm. Successful degradations of the copolymers were achieved under basic conditions, which demonstrated the incorporation of labile thioester groups in the copolymer backbone.
Rapid Biomolecular Trifluoromethylation Using Cationic Aromatic Sulfonate Esters as Visible Light-Triggered Radical Photocages
Authors: Kuehl Nicholas , Taylor Michael
Published: July 2023

Described here is a photo-decaging approach to radical trifluoromethylation of biomolecules. This was accomplished by designing a quinolinium sulfonate ester that, upon absorption of visible light, achieves decaging via photolysis of the sulfonate ester to ultimately liberate free trifluoromethyl radicals that are trapped by π-nucleophiles in biomolecules. This photo-decaging process enables protein and protein-interaction mapping experiments using trifluoromethyl radicals that require only one second reaction times and low photo-cage concentrations. In these experiments, aromatic side chains are labelled in an environmentally dependent fashion, with selectivity observed for tryptophan (Trp), followed by histidine (His) and tyrosine (Tyr). Scalable peptide trifluoromethylation through photo-decaging is also demonstrated, where bespoke peptides harboring trifluoromethyl groups at tryptophan residues can be synthesized with five to seven minute reaction times and good yields.
Prevalence Of Thyroid Hormones Test Abnormality In Females At Reproductive Age Attending Al-batool Maternity Teaching Hospital
Authors:   College of Medicine, University of Diyala, Diyala , Iraq, Abdulkareem Salman Mustafa
Published: July 2023

Background: Although there is little information about the prevalence of thyroid disorders in young women, but they are common in Iraq. Objective: To prevalence of thyroid hormones test abnormality in females at reproductive age attending al-batool maternity teaching hospital Patients and Methods: This study involved 1570 of reproductive female ages patients at the Al-batool Maternity Hospital in Diyala Province, Iraq. Serum levels of T3, T4, and TSH were measured in this study. According to the conventional definitions of T3, T4, and TSH levels of overt hyper- and hypothyroidism patients were grouped according to their thyroid status at the time of testing. Results: A total of 1570 subjects were screened of whom 152 subjects (18.6%) had abnormal TSH. The overall prevalence of hyperthyroidism with elevated TSH was 17.4%, of which 1.2% had hypothyroidism with elevated TSH. A low TSH was seen in 1.3% of the study population (P= 0.001). Generally, thyroxin hormone (T4) abnormalities were totaled at 12.02%, of which 10.22% were hypothyroidism and 1.8% was hyperthyroidism. Furthermore, the triiodothyroxin hormone T4 abnormality percentage was 14.84%, compared to hypothyroidism of 3.12% and hyperthyroidism of 11.72%. Conclusion: Thyroid dysfunction was common in young women. Therefore, females more susceptible to thyroid disorders. Keywords: prevalence, thyroid‑stimulating hormone, hyperthyroidism, hypothyroidism, Iraq, women
ATP5b and Bioenergetic Plasticity in Breast Cancer Metastasis and Tumour Microenvironment Interactions
Authors:   , Lewthwaite Danielle
Published: July 2023

Breast cancer is the most diagnosed form of cancer in New Zealand, with the majority of breast cancer associated deaths attributed to metastasis. During the metastatic cascade, tumour cells have been shown to alter the contributions of glycolysis and oxidative phosphorylation to overall ATP generation, indicating a need for tumour cell bioenergetic plasticity during metastasis. These changes in tumour cell bioenergetics are also influenced by interactions with other cell populations in the tumour microenvironment.

This project assessed the ability of 4T1 ATP5b lo cells to form lung metastases in BALB/c mice. As ATP5b encodes a sub-unit of ATP synthase, these cells had a reduced ability to produce ATP via oxidative phosphorylation, thereby reducing their bioenergetic plasticity compared to WT cells. 4T1 ATP5b lo and WT cells were first transfected with the fluorescent protein tdTomato to allow tumour cell visualisation. Both cell lines were characterised by assessing growth rate and oxygen consumption profiles.

Intravenous injection of 1 x 106 ATP5b lo tdTomato cells into the lateral tail vein resulted in the formation of experimental lung metastases with no significant difference in metastatic burden observed with respect to WT tdTomato injected mice. This indicated these cells with slightly reduced ATP5b expression possessed sufficient bioenergetic plasticity to lodge in the lungs and proliferate when administered directly into the bloodstream. Further research is required to validate these results in a more extreme model of reduced bioenergetic plasticity and assess whether bioenergetically compromised cells can undergo the complete metastatic cascade beyond intravenous seeding within the lung.

As tumour cell bioenergetics is linked with the presence and function of other cells within the tumour microenvironment, neutrophil and macrophage abundance/localisation was also assessed via immunofluorescent staining. No significant differences in neutrophil and macrophage abundance/localisation were observed between both treatment groups. Further investigation is required to elucidate whether the function of tumour microenvironment cell populations is altered in response to a reduction in tumour cell bioenergetic plasticity.
Test Deposit; Please Ignore
Authors:   , Atkins Ori
Published: July 2023

Testing FoR v2 in prod
LA REMOCIÓN DE AUTORIDADES, UN DERECHO CIUDADANO CONTRA LA CORRUPCIÓN SIN ESTRENAR
Authors:   UNIVERSIDAD CATOLICA DE SANTA MARIA, AREQUIPA-PERU, MANRIQUE SALINAS JOSÉ ANTONIO
Published: July 2023

La remoción, como derecho fundamental de control ciudadano según el marco jurídico peruano no registra desarrollo reglamentario ni doctrinario, llámese artículo científico o resolución que dilucide su práctica. Como mecanismo institucional existen algunos antecedentes históricos que el artículo explora y considera para su desarrollo. Se ha elaborado un análisis jurídico e institucional sobre las implicancias de este derecho de control ciudadano aún sin aplicar desde una perspectiva diacrónica, a la luz del derecho nacional y comparado, realizando una evaluación objetiva con el fin de determinar la mejor manera de poner en práctica la remoción vigente como derecho fundamental y como mecanismo participativo. Se determinó que, al igual que la revocatoria, es un derecho fundamental y una institución de control ciudadano, aún sin usar, que ayudará de forma relevante en la lucha contra la corrupción y la inepcia de las autoridades públicas, hoy desbordada. Sin embargo, se requieren algunas precisiones de carácter técnico con el fin de viabilizar, facilitar y mejorar su aplicación y accesibilidad para los ciudadanos. Palabras clave: remoción, derecho, político, control, corrupción, mecanismo, requisitos
USE OF HUMANIZED OFF-LABEL MONOCLONAL ANTIBODIES IN PEDIATRIC PRACTICE
Authors: K.O. Schneider , M.L. Maksimov , B.K. Romanov , O.A. Gusarova , V.A. Baranova
Published: July 2023

In recent years, the use of off-label drugs (the use of drugs for indications not approved by state regulatory bodies, and also not mentioned in the instructions for use) has become widespread in the pediatric population. For a long time, clinical trials in the pediatric population were considered difficult to conduct due to ethical issues, leading to frequent off-label drug use. Off-label drug use remains an important public health problem, especially in children with rare diseases or diseases not responding to standard treatment.
The purpose of the review is to analyze foreign literature sources on the use of biological preparations outside the instructions. The use of drugs outside the instructions (off-label) is a topical issue in the clinical practice of doctors of various specialties, and this is especially in demand in pediatric practice. This is due to the fact that a registered drug may have a successful experience in adults, but at the same time not have official approval for use in children. The need to use drugs outside the instructions for use, as a rule, occurs in patients with severe, chronic, life-threatening pathology.
Further studies analyzing their efficacy, safety, and cost-benefit ratio are needed to expand the use of biological therapy in the pediatric population.
INFLUENCE OF PUMPKIN SEED OIL ON THE RATE OF OXYGEN CONSUMPTION BY THE PROSTATE TISSUE
Authors: A.O. Lobkarev , R.Kh. Khafizyanova
Published: July 2023

Despite a long and successful experience with the use of pumpkin seed oil (PSO) in patients with chronic prostatitis (CP), the pharmacodynamics of PSO is not fully understood. We hypothesized that pumpkin seeds and PSO contain pharmacologically active substances that are able to influence on the rate of oxygen consumption (ROC) by the prostate tissue, which may be a determinant of their effectiveness in men with CP. The aim: to study the effect of eating pumpkin seeds, containing PSO, on the ROC of the prostate tissue in white outbred rats. Materials and methods. The control group consisted of 16 outbred male rats. The experimental group consisted of 6 white outbred male rats, which on the eve received, in addition to the standard diet, pumpkin seeds without restriction. Thus, 22 adult outbred male rats were used in the study. The ROC of the prostate tissue was measured by an optical sensor of dissolved oxygen with a DKTP-03 thermoelectric converter. A prostatectomy was performed under anesthesia. Immediately after that, prostate tissue weighing 0.5 g was placed in a beaker, filled with 15.0 ml of 0.9% sodium chloride solution at a temperature of 36.6 °C. An optical oxygen sensor DKTP-03 connected to an oxygen analyzer "Expert-009" was placed in a beaker and the tightness was created. The analyzer showed the concentration of dissolved molecular oxygen (CDO2) in a 0.9% solution of sodium chloride, expressed in mg / l. We recorded the CDO2 readings every minute from the beginning of the experiments (0 minutes) to their end (60 minutes). Results and conclusion. we have found for the first time that PSO statistically significantly increases the ROC in rat prostate tissue (p < 0.05).
USE OF NEURAL NETWORKS FOR PREDICTION OF COMPLICATIONS OF THE GESTATION PERIOD
Authors: N.V. Lazareva
Published: July 2023

The article discusses in detail the development, use and use of neural networks for practical healthcare, especially in predicting the development of complications and preventing the development of complications. This is especially relevant now given the expected risk of adverse outcomes during pregnancy. Neural networks are obtained by themselves, simple elements are built among themselves - formal neurons. Most of the work on neuroinformatics is devoted to the transfer of various algorithms for solving problems in such networks. The core of the ideas used is the idea that neurons can be modeled by fairly simple automata, and the complexity of the brain, the flexibility of its functioning, and other important qualities are determined by the connections between neurons. The purpose of this study: was the development of neural network expert programs as the most important method for researching medical data.
Our study was the result of testing the possibility of using neural networks in obstetrics and gynecology to predict gestational complications and the development of placental insufficiency. The definition of the risk group was carried out on the basis of the model developed by us. A neural network for prediction was developed, the possibility of using this model in obstetrics and gynecology was tested to predict gestational complications in 1024 women with a high risk of developing this pathology. Confirming the effectiveness of the proposed model, based on the data obtained from a prospective study, we calculated the indicators of its sensitivity, specificity, positive and negative predictive value. The result of the study confirms that the trained neural network makes a reliable prediction of the development of gestational complications and the development of insufficiency of the placental complex. As a result of the research, an important conclusion can be drawn that neural networks are the most important method for studying medical data, universal and highly effective, focused on active use in practical medicine.
POSITION OF STUDENTS OF MEDICAL UNIVERSITY TO A HEALTHY WAY OF LIFE
Authors: Zh.B. Naberezhnaya , A.A. Romakhova
Published: July 2023

Healthy way of life many-sided enough concept. Different people on it treat. For one is a refusal of bad habits, for others employment by physical culture and sports, for the third it is a rational mode of day and the balanced feed. Objective of our research was studying knowledge of students of medical university about a healthy way of life and aspiration to its introduction. Sociological interrogation by questioning 151 students of pediatric faculty has been lead. For this purpose, the questionnaire consisting of twenty-seven questions, which have been incorporated, in five sections has been created. During carrying out of research it has been revealed, that a healthy way of life connects 2/3 students with absence of bad habits, a balanced diet, a healthy dream and playing sports. The basic source of reception of the information on a healthy way of life was the Internet. Also consultations of doctors and the literature have noted been. A healthy way of life conduct half proquestioned, from them the majority do sports and on a regular basis and it is adequate eat. Among respondents non-smoking students prevailed, the use of alcohol with various frequency has noted been at 1/3 and basically only on holidays. Among students of the Centers health knowing about functioning only 2/5 are informed to the fullest on an orientation of their activity. Results of sociological interrogation have shown, that half of respondents take of a positive position to a healthy way of life as know about the given concept and adhere to it. But, availability of negative behavioral factors speaks about a negative position of other half of respondents.
METHODS OF PREDICTING THE TIME OF PROBABLE EXACERBATIONS AND ATTACKS OF BRONCHIAL ASTHMA IN CHILDREN
Authors: Yu.D. Vybornov
Published: July 2023

The purpose of the research is to determine the periodicity of exacerbations, attacks of bronchial asthma (BA) in children and their prediction. In 1993, 2 computer programs were registered, modified in 2014. Program No. 2014610977 "Determination of the hereditary periodicity of human diseases and prediction of the time of his probable diseases with acute onset". The program's database contains information about the diseases of 2,400 people, including 30 children with BA. Their periodicity of diseases was determined, dominant rhythms (DR) were calculated and digital doubles were identified, in which at least three DRS coincided within 1 day. In some children, DRS have been identified, which are associated with 50% - 70% of the diseases suffered, including seizures and exacerbations of AD. DR was used for computer prediction of the time of prob. In some children, DRS have been identified, which are associated with 50% - 70% of the diseases suffered, including attacks and exacerbations of BA. DR was used for computer prediction of the time of probable exacerbations and attacks of AD with an error of +4 days. Forecasts of up to 45% of probable diseases for a digital double of one of the parents or a doubles who is not related were inferior in accuracy to the first method. The prevailing influence on the time of occurrence of acute infectious diseases, as well as exacerbations and attacks of asthma, is exerted by genetically programmed DR. Random factors (infection, hypothermia, stress, allergens ...), coinciding with the predicted date, provoke the occurrence of pathologies. The purpose of the forecasts is timely prevention, reduction of morbidity and infant mortality. Computer program can be used to determine the periodicity and forecast of earthquakes in different regions of the Earth, hurricanes, sudden changes in the average daily air temperature.
FEATURES OF CORONAVIRUS INFECTION IN A RENAL TRANSPLANT RECIPIENT
Authors: S.M. Yudina , V.V. Kiseleva , Yu.A. Rogova , T.S. Rusanova , I.Yu. Makeeva , I.A. Ivanova , A.V. Arkhipova , V.V. Volkov
Published: July 2023

The new coronavirus infection poses a particular threat to patients receiving immunosuppressive therapy, including those with a history of organ transplantation. The article provides a clinical observation of coronavirus infection in a kidney transplant recipient.
Patient M., 61 years old, was admitted to the infectious diseases department of the Kursk City Clinical Hospital No. 4 with complaints of high fever, cough, shortness of breath, severe weakness, loss of appetite. When examining a swab from the nose and throat by PCR for SARS-Cov-2 RNA, a positive result was obtained. Based on the clinical picture, computed tomography of the lungs, positive PCR result for SARS-Cov-2 RNA, the diagnosis was made: Coronavirus infection Covid-19 confirmed, moderate form. Bilateral polysegmental pneumonia of moderate severity. RF - 0-I degree (CT-1). Bilateral nephrosclerosis. Condition after kidney transplant (2006). On the fifth day, the patient's condition worsened, which was combined with the progression of lung damage according to CT of the chest to 45% (CT-2), the appearance of signs of acute respiratory distress syndrome. Taking into account the severity of the patient's condition, a consultation was held with a transplantologist and a decision was made to correct immunosuppressive therapy with temporary withdrawal of cyclosporine. Over the next two days, the patient's condition remained stably grave. Subsequently, against the background of complex therapy, including glucocorticosteroids, antibacterial drugs, monoclonal antibodies to the interleukin-6 receptor, positive dynamics was noted in the form of a decrease in shortness of breath, cough, normalization of body temperature, and an increase in SpO2 up to 95%. This was combined with the restoration of disturbed laboratory parameters and the positive dynamics of the inflammatory process in the lungs according to CT scans. The treatment of kidney transplant recipients with Covid-19 has a number of features due to a pronounced suppression of the immune system against the background of immunosuppressive therapy and, as a result, the development of a severe infection, often with impaired graft function. At the same time, despite the severity of the course of the infectious process, the complete abolition of immunosuppressive therapy is not carried out, but its correction is carried out in the form of the exclusion of one of the drugs and a decrease in the dose of other immunosuppressants. Coronavirus infection in patients with a history of organ transplantation justifies the need for timely hospitalization and correction of immunosuppressive therapy to prevent a severe course of the disease and adverse outcomes.