bluuebunny/crossref_metadata_2025 huggingface dataset:
Proteomic Comparison of Malignant Human Germ Cell Tumor Cell Lines
Authors: Bremmer Felix , Bohnenberger Hanibal , Küffer Stefan , Oellerich Thomas , Serve Hubert , Urlaub Henning , Strauss Arne , Maatoug Yasmine , Behnes Carl Ludwig , Oing Christoph , Radzun Heinz Joachim , Ströbel Philipp , Balabanov Stefan , Honecker Friedemann
Published: September 2019

Malignant germ cell tumors (GCT) are the most common malignant tumors in young men between 18 and 40 years. The correct identification of histological subtypes, in difficult cases supported by immunohistochemistry, is essential for therapeutic management. Furthermore, biomarkers may help to understand pathophysiological processes in these tumor types. Two GCT cell lines, TCam-2 with seminoma-like characteristics, and NTERA-2, an embryonal carcinoma-like cell line, were compared by a quantitative proteomic approach using high-resolution mass spectrometry (MS) in combination with stable isotope labelling by amino acid in cell culture (SILAC). We were able to identify 4856 proteins and quantify the expression of 3936. 347 were significantly differentially expressed between the two cell lines. For further validation, CD81, CBX-3, PHF6, and ENSA were analyzed by western blot analysis. The results confirmed the MS results. Immunohistochemical analysis on 59 formalin-fixed and paraffin-embedded (FFPE) normal and GCT tissue samples (normal testis, GCNIS, seminomas, and embryonal carcinomas) of these proteins demonstrated the ability to distinguish different GCT subtypes, especially seminomas and embryonal carcinomas. In addition, siRNA-mediated knockdown of these proteins resulted in an antiproliferative effect in TCam-2, NTERA-2, and an additional embryonal carcinoma-like cell line, NCCIT. In summary, this study represents a proteomic resource for the discrimination of malignant germ cell tumor subtypes and the observed antiproliferative effect after knockdown of selected proteins paves the way for the identification of new potential drug targets.
Antibiotic Resistance of Enteric Bacteria in HIV-Infected Patients at the Banka Ad-Lucem Hospital, West Region of Cameroon
Authors: Ngalani Ornella J. T. , Mbaveng Armelle T. , Marbou Wiliane J. T. , Ngai Roland Y. , Kuete Victor
Published: September 2019

Human immunodeficiency virus (HIV) infection is a serious problem throughout the world and especially in developing countries. This study was conducted to define the bacterial aetiologies of enteric disorders and their association with CD4+ T-lymphocyte cell count and serum hs-CRP in HIV-seropositive patients coming for consultation at the AD-Lucem Banka Hospital. Stool samples from one-hundred HIV-positive patients with enteric disorders and forty HIV negative patients with enteric disorders were examined for the presence of bacteria by different diagnostic techniques. CD4+ T-lymphocyte count and serum hs-CRP of HIV-positive and HIV-negative patients were examined, respectively, by flux cytometry and the ELISA solid-phase direct sandwich method. Among all the participants, 39 (26.35%) were males and 109 (73.65%) were females. HIV-seropositive mean age (43.79 years) was significantly higher compared to HIV-seronegative (27.13 years) patients (p<0.000). The average values of CD4+ T-cell count (p<0.0001), lymphocytes (p=0.0258), monocytes (p=0.0317), and total WBC count (p=0.0277) were significantly higher in HIV− patients compared to HIV+ patients. Salmonella sp., Escherichia coli, and Klebsiella pneumoniae were more isolated in HIV+ patients 5 (83.33), 18 (75.00), and 37 (71.15) compared to HIV− patients 1 (16.67), 6 (25.00), and 15 (28.85), respectively. Majority of isolates were susceptible to IPM, NOR, and CIP. Klebsiella pneumoniae, the most prevalent isolate, showed resistance to AMC (45.95) in HIV+ patients, whereas in HIV− patients, Enterobacter aerogenes and Shigella sp. showed resistance to AMC (80.00% and 85.71%, respectively) and to CFM (80.00% and 57.14%, respectively). Enterobacter aerogenes (40.00%) and Shigella sp. (14.29) isolates showed multidrug resistance in HIV− patients, whereas Escherichia coli (5.56%) and Klebsiella pneumoniae (2.70%) showed multidrug resistance in HIV+ patients. Understanding the burden of bacteria disease in HIV patients as shown in the present study is important for planning effective control programs for the overall reduction of bacteria diseases in HIV-infected patients.
Playback of Fork-Marked Lemurs’ Loud Calls in Kirindy Forest, Madagascar
Authors: Forbanka Derick Nomuh
Published: September 2019

Primate loud calls often encode information relating to species identity. A previous study of loud calls of fork-marked lemurs (genus Phaner) indicated differences among the calls of four populations that have been accorded species status on the grounds of morphology and biogeography: Phaner electromontis, P. parienti, P. furcifer and P. pallescens. I made field recordings of two typical calls (kiu and kea) emitted by all four populations and conducted playback experiments in Kirindy Forest to investigate whether free-ranging P. pallescens individuals could discriminate the loud calls of their own species from those of others. Individual response behaviour, social context and call type used in playback were analysed using a goodness-of-fit G test. The effect of specific call identity was significant, while the effects of context and call type were not. Individuals responded to P. pallescens calls by approaching the speaker, but not to the calls of other populations. P. pallescens individuals appear to be capable of distinguishing the loud calls of their conspecifics, but the fact that the habitat structure of the sites of recording and playback of P. pallescenscalls was similar sounds a note of caution. Future studies should repeat the experiments with the other populations of fork-marked lemurs.
Effects of Exercise on Muscle Fitness in Dialysis Patients: A Systematic Review and Meta-Analysis
Authors: Lu Yue , Wang Yujie , Lu Qian
Published: September 2019

Background: Lack of exercise is a prevalent problem in patients receiving dialysis. Although guidelines recommend these patients to undertake suitable exercise, no exercise type or intensity has been suggested, and the effect of exercise on muscle fitness in dialysis patients is not clear. This study investigated the effect of exercise on muscle fitness, including muscle mass, muscle strength, and physical performance, in patients on dialysis. Methods: A systematic review and a meta-analysis of randomized controlled trials (RCTs) were conducted. Five English and 4 Chinese databases were searched from their inception to July 2018. Two independent reviewers searched the different databases, selected trials, conducted bias assessment, and extracted the data. Results: A total of 21 RCTs meeting the inclusion criteria were included in this review. Pooled results demonstrated that resistance training significantly improved leg mass (standard mean difference [SMD] 0.34, 95% CI [0.06–0.62], p= 0.02) whereas aerobic training did not (SMD 0.87, 95% CI [–0.11 to 1.86], p = 0.08). Resistance training increased both grip strength (weighted mean difference [WMD] 4.71 kg, 95% CI [2.42–6.99], p < 0.00001) and knee extension strength (WMD 3.93 kg, 95% CI [0.59–7.28], p = 0.02) significantly. Aerobic training improved grip strength (WMD 7.70 kg, 95% CI [3.35–12.05], p= 0.005) and the time of finishing short version of the sit-to-stand test (STS; WMD –4.69 s, 95% CI [–9.01 to –0.38], p = 0.03) but with insufficient evidence. In the dimension of physical performance, both aerobic training and resistance training have some beneficial effect on improving the score of 6-min walking test (WMD 85.76 m, 95% CI [63.43–108.09], p < 0.00001; WMD 41.92 m, 95% CI [8.06–75.75], p = 0.02, respectively) and median version of STS test (WMD 4.30 repetitions, 95% CI [1.22–7.39], p = 0.006; WMD 2.60 repetitions, 95% CI [0.64–4.56], p = 0.006, respectively). Conclusions: Regular resistance training with a moderate to high intensity may lead to improvement in muscle mass and muscle strength of patients undergoing dialysis, especially for the trained muscles. Both aerobic training and resistance training may help dialysis patients improve physical performance.
Dança e engajamento político no trabalho do grupo Pró-Posição
Authors: Nhur Andréia
Published: September 2019

Parte resultante da pesquisa realizada em 2012, na tese de doutorado intitulada Cartografias midiáticas: o corpomídia na construção da memória da dança, este artigo apresenta possíveis entrelaçamentos históricos entre a dança paulista emergente na década de 1970 e os acontecimentos culturais e políticos que marcaram a época. A partir de relatos e documentos sobre a produção do grupo Pró-Posição Ballet-Teatro e seus fundadores – Janice Vieira e Denilto Gomes –, este estudo aventa traçados historiográficos em torno de fatos e movimentos que direcionaram divisões políticas e produções artísticas de vanguarda em face à ditadura militar pós-AI-5.
O espetáculo de Philip Astley (Paris, 1786)
Authors: Bolognesi Mario Fernando
Published: September 2019

Documento anônimo de 1887 descreve e comenta um espetáculo circense apresentado pela companhia de Philip Astley, em 1786, em Paris. Ele se baseia em escritos de Pidansat de Mairobert. O espetáculo de Astley era organizado a partir do princípio da montagem de atrações, base para os futuros espetáculos circenses.
Circulating Monocyte Chemoattractant Protein-1 and Risk of Stroke
Authors: Georgakis Marios K. , Malik Rainer , Björkbacka Harry , Pana Tiberiu Alexandru , Demissie Serkalem , Ayers Colby , Elhadad Mohamed A. , Fornage Myriam , Beiser Alexa S. , Benjamin Emelia J. , Boekholdt S. Matthijs , Engström Gunnar , Herder Christian , Hoogeveen Ron C. , Koenig Wolfgang , Melander Olle , Orho-Melander Marju , Schiopu Alexandru , Söderholm Martin , Wareham Nick , Ballantyne Christie M. , Peters Annette , Seshadri Sudha , Myint Phyo K. , Nilsson Jan , de Lemos James A. , Dichgans Martin
Published: September 2019

Rationale:

Proinflammatory cytokines have been identified as potential targets for lowering vascular risk. Experimental evidence and Mendelian randomization suggest a role of MCP-1 (monocyte chemoattractant protein-1) in atherosclerosis and stroke. However, data from large-scale observational studies are lacking.

Objective:

To determine whether circulating levels of MCP-1 are associated with risk of incident stroke in the general population.

Methods and Results:

We used previously unpublished data on 17 180 stroke-free individuals (mean age, 56.7±8.1 years; 48.8% men) from 6 population-based prospective cohort studies and explored associations between baseline circulating MCP-1 levels and risk of any stroke, ischemic stroke, and hemorrhagic stroke during a mean follow-up interval of 16.3 years (280 522 person-years at risk; 1435 incident stroke events). We applied Cox proportional-hazards models and pooled hazard ratios (HRs) using random-effects meta-analyses. After adjustments for age, sex, race, and vascular risk factors, higher MCP-1 levels were associated with increased risk of any stroke (HR per 1-SD increment in ln-transformed MCP-1, 1.07; 95% CI, 1.01–1.14). Focusing on stroke subtypes, we found a significant association between baseline MCP-1 levels and higher risk of ischemic stroke (HR, 1.11 [1.02–1.21]) but not hemorrhagic stroke (HR, 1.02 [0.82–1.29]). The results followed a dose-response pattern with a higher risk of ischemic stroke among individuals in the upper quartiles of MCP-1 levels as compared with the first quartile (HRs, second quartile: 1.19 [1.00–1.42]; third quartile: 1.35 [1.14–1.59]; fourth quartile: 1.38 [1.07–1.77]). There was no indication for heterogeneity across studies, and in a subsample of 4 studies (12 516 individuals), the risk estimates were stable after additional adjustments for circulating levels of IL (interleukin)-6 and high-sensitivity CRP (C-reactive protein).

Conclusions:

Higher circulating levels of MCP-1 are associated with increased long-term risk of stroke. Our findings along with genetic and experimental evidence suggest that MCP-1 signaling might represent a therapeutic target to lower stroke risk.Visual Overview: An online visual overview is available for this article.
Following Schrödinger's Code: A Personal Journey
Authors: Gazzaniga Michael S.
Published: September 2019

On a wintery afternoon over 60 years ago, I was browsing the Baker Library stacks at Dartmouth College and stumbled across a small book with an arresting title: What Is Life? [Schrödinger, E. What is Life? The physical aspect of the living cell and mind. Cambridge: Cambridge University Press, 1944]. This small volume contained numerous concepts that would transform the future of the biological sciences, giving rise to new fields, dogmas, approaches, and debates. Here, I present the core concepts of Schrödinger’s book, the influence they have had on biology, and the influence they may continue to have on the cognitive neurosciences.
Otacilia fansipan spec. nov., the second congener recorded from Vietnam
(Arachnida: Araneae: Phrurolithidae)
Authors: JÄGER PETER , DIMITROV DRAGOMIR
Published: September 2019

A new species of the genus Otacilia Thorell, 1897 is described from northern Vietnam: O. fansipan spec. nov. It represents the second species of the genus recorded from that country. Special papillae are found on the surface of the spermathecae, their function is unknown. A distribution map is presented with all records of the genus, with a first attempt to explain its biogeography.
A new Andiperla Aubert (Plecoptera, Gripopterygidae) species from the Perito Moreno Glacier, Argentina
Authors: PESSACQ PABLO , RIVERA-POMAR ROLANDO
Published: September 2019

Andiperla morenensis n. sp. is described from the Perito Moreno Glacier, Santa Cruz Province, Argentina. The new species differs from its only congener, A. willinki, Aubert, 1956 by tergum X produced into an acute lobe directed posteriorly and by the presence of a small epiproct. The18S rRNA and COI gene sequence of A. morenensis n. sp. is provided.
A Two-Level Alternating Direction Model for Polytomous Items With Local Dependence
Authors: Himelfarb Igor , Marcoulides Katerina M. , Fang Guoliang , Shotts Bruce L.
Published: September 2019

The chiropractic clinical competency examination uses groups of items that are integrated by a common case vignette. The nature of the vignette items violates the assumption of local independence for items nested within a vignette. This study examines via simulation a new algorithmic approach for addressing the local independence violation problem using a two-level alternating directions testlet model. Parameter values for item difficulty, discrimination, test-taker ability, and test-taker secondary abilities associated with a particular testlet are generated and parameter recovery through Markov Chain Monte Carlo Bayesian methods and generalized maximum likelihood estimation methods are compared. To aid with the complex computational efforts, the novel so-called TensorFlow platform is used. Both estimation methods provided satisfactory parameter recovery, although the Bayesian methods were found to be somewhat superior in recovering item discrimination parameters. The practical significance of the results are discussed in relation to obtaining accurate estimates of item, test, ability parameters, and measurement reliability information.
Republished: Systematic Review of Handoff Mnemonics Literature
Authors: Riesenberg Lee Ann , Leitzsch Jessica , Little Brian W.
Published: September 2019

A systematic review of published English-language articles on handoffs is conducted (1987 to June 4, 2008). Forty-six articles describing 24 handoff mnemonics are identified by trained reviewers. The majority (82.6%) have been published in the last 3 years (2006-2008), and SBAR (Situation, Background, Assessment, Recommendation) is the most frequently cited mnemonic (69.6%). Of 7 handoff research articles, only 4 study mnemonics. All 4 of these studies have relatively small sample sizes (10-100) and lack validated instruments. Only 1 study has obtained IRB approval. Scientifically rigorous research studies are needed to assess the effectiveness of handoff mnemonics. These should be published in the peer-reviewed literature using the Standards for QUality Improvement Reporting Excellence (SQUIRE) guidelines.
What Is the Risk of Harm Associated With Topical Calcineurin Inhibitors?
Authors: Hanna Sam , Zip Catherine , Shear Neil H.
Published: September 2019

The topical calcineurin inhibitors (TCIs), tacrolimus (Protopic) and pimecrolimus (Elidel), were approved in the early 2000s and were widely used as a nonsteroid treatment for atopic dermatitis (AD) in adult and pediatric populations. In 2005, the addition of a boxed warning was mandated for TCIs based on a potential risk of malignancy, and there was subsequently a substantial decline in their use. Since then, evidence has mounted to support the safety of this class of medications and suggests that the increased risk of malignancy remains theoretical. This review aims to dispel some of the common myths surrounding the safety of TCIs by evaluating the key evidence regarding their safety and tolerability in adult and pediatric populations. Four major themes are addressed in a practical question-and-answer format: the risk of harm associated with TCIs including common and serious adverse events; warnings and precautions for their use including the risk of systemic absorption, immunosuppression, and malignancy; the comparative safety of TCIs; and suggestions for counselling patients about the risk of harm with TCIs. Based on the available evidence, international professional dermatological organizations and regulatory authorities have concluded that the benefits of TCIs outweigh their potential risks when used in the appropriate patient populations for the recommended duration of time.
Familial occurrence of mitral regurgitation in patients with mitral valve prolapse undergoing mitral valve surgery
Authors: Hiemstra Yasmine L , Wijngaarden Aniek L van , Bos Mathilde W , Schalij Martin J , Klautz Robert JM , Bax Jeroen J , Delgado Victoria , Barge-Schaapveld Daniela QCM , Marsan Nina Ajmone
Published: September 2019

Background

Initial studies have suggested the familial clustering of mitral valve prolapse, but most of them were either community based among unselected individuals or applied non-specific diagnostic criteria. Therefore little is known about the familial distribution of mitral regurgitation in a referral-type population with a more severe mitral valve prolapse phenotype. The objective of this study was to evaluate the presence of familial mitral regurgitation in patients undergoing surgery for mitral valve prolapse, differentiating patients with Barlow's disease, Barlow forme fruste and fibro-elastic deficiency.

Methods

A total of 385 patients (62 ± 12 years, 63% men) who underwent surgery for mitral valve prolapse were contacted to assess cardiac family history systematically. Only the documented presence of mitral regurgitation was considered to define ‘familial mitral regurgitation’. In the probands, the aetiology of mitral valve prolapse was defined by surgical observations.

Results

A total of 107 (28%) probands were classified as having Barlow's disease, 85 (22%) as Barlow forme fruste and 193 (50%) patients as fibro-elastic deficiency. In total, 51 patients (13%) reported a clear family history for mitral regurgitation; these patients were significantly younger, more often diagnosed with Barlow's disease and also reported more sudden death in their family as compared with ‘sporadic mitral regurgitation’. In particular, ‘familial mitral regurgitation’ was reported in 28 patients with Barlow's disease (26%), 15 patients (8%) with fibro-elastic deficiency and eight (9%) with Barlow forme fruste (P < 0.001).

Conclusions

In a large cohort of patients operated for mitral valve prolapse, the self-reported prevalence of familial mitral regurgitation was 26% in patients with Barlow's disease and still 8% in patients with fibro-elastic deficiency, highlighting the importance of familial anamnesis and echocardiographic screening in all mitral valve prolapse patients.
“Mini” bank of only 8 donors supplies CMV-directed T cells to diverse recipients
Authors: Tzannou Ifigeneia , Watanabe Ayumi , Naik Swati , Daum Rachel , Kuvalekar Manik , Leung Kathryn S. , Martinez Caridad , Sasa Ghadir , Wu Mengfen , Gee Adrian P. , Krance Robert A. , Gottschalk Stephen , Heslop Helen E. , Omer Bilal
Published: September 2019

Cytomegalovirus (CMV) infections remain a major cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HSCT), and standard antiviral therapies are associated with significant side effects and development of drug-resistant mutants. Adoptively transferred donor-derived CMV-specific T cells (CMVSTs) can provide an alternative treatment modality with few side effects but are not widely available due to their patient-specific nature. Here we report the establishment and use of a bank of CMVSTs derived from just 8 CMV-seropositive donors, with HLA types representing the diverse US population, as an “off-the-shelf” therapy to treat drug-refractory infections. To date, we have screened 29 patients for study participation and identified a suitable line, with ≥2 of 8 shared HLA antigens, for 28 (96.6%) patients with a median of 4 shared HLA antigens. Of these, 10 patients with persistent/refractory CMV infections or disease were eligible for treatment; a single infusion of cells produced 3 partial responses and 7 complete responses, for a cumulative response rate of 100% (95% confidence interval, 69.2-100) with no graft-versus-host disease, graft failure, or cytokine release syndrome. Potential wider use of the tested CMVSTs across transplant centers is made more feasible by our ability to produce sufficient material to generate cells for >2000 infusions from a single donor collection. Our data indicate that a “mini” bank of CMVSTs prepared from just 8 well-chosen third-party donors can supply the majority of patients with an appropriately matched line that produces safe and effective anti-CMV activity post-HSCT.
Kinetics and mechanism of thermal degradation of vegetable-tanned leather fiber
Authors: Liu Jie , Luo Lan , Hu Yadi , Wang Fang , Zheng Xuejing , Tang Keyong
Published: September 2019

Thermal degradation of vegetable-tanned leather fiber (VLF) was investigated by thermogravimetric analysis aiming to know the exact kinetics and degradation mechanism. The thermogravimetric (TG) and differential thermogravimetric (DTG) curves showed that decomposition of the VLF occurs mainly in the range of 150–600 °C, and the latter exhibits asymmetrical peak with a pronounced shoulder. The decomposition process was first analyzed by deconvolution of the experimental DTG curves, followed by reconstruction of the weight loss profiles of two individual processes. Several common isoconversional approaches were applied to calculate the activation energy over a wide range of conversion for the sample, including modified Kissinger-Akahira-Sunose (MKAS), Friedman, and Flynn-Wall-Ozawa. The average activation energy of vegetable-tanned leather fiber was found to be 241.9 kJ mol− 1 by MKAS method. The activation energy values obtained for the pseudocomponents representing highly-crosslinked and low-crosslinked collagen in VLF were given as 190.6 and 124.8 kJ mol− 1, respectively. Generalized master plots results suggested that the reaction mechanism for highly-crosslinked collagen follows the random nucleation and growth process at conversion values lower than 0.5. When the conversion is higher than 0.5, the mechanism tends to random scission model. For low-crosslinked collagen, the degradation is mainly governed by random nucleation and nuclei growth. The gaseous products of VLF thermal degradation were analyzed with an online-coupled TG-Fourier transform infrared spectroscopy system.

Graphical abstract
A Randomized Community-based Exercise Training Trial in African American Men: Aerobic Plus Resistance Training and Insulin Sensitivity in African American Men
Authors: NEWTON ROBERT L. , JOHNSON WILLIAM D. , LARRIVEE SANDRA , HENDRICK CHELSEA , HARRIS MELISSA , JOHANNSEN NEIL M. , SWIFT DAMON L. , HSIA DANIEL S. , CHURCH TIMOTHY S.
Published: September 2019

Purpose

To examine the impact of a community-based exercise training intervention on cardiometabolic outcomes in African American men who have a family history of type 2 diabetes.

Methods

The Aerobic Plus Resistance Training and Insulin Sensitivity in African American Men (ARTIIS) study randomized participants into either an exercise training intervention or an information only control group for 5 months. The exercise training intervention consisted of 150 min of moderate intensity aerobic activity and 2 d of resistance training per week, consistent with the current federal physical activity guidelines. Participants in the control group received monthly newsletters featuring topics focused heavily on type 2 diabetes education and prevention. Outcome data were analyzed using repeated-measures ANCOVA models and incorporating both intention-to-treat and per-protocol principles.

Results

Adherence to the aerobic and resistance training prescriptions were between 77% and 79%. Despite significant within group improvements in glucose and insulin levels (fasting, 2 h, 2 h minus baseline) and Homeostatic Model 2-Insulin Resistance, there were not significant between group differences. There was a marginally significant between group difference for Homeostatic Model 2-Beta (P < 0.06), and significant between group differences in peak cardiorespiratory fitness (P < 0.001) and waist circumference (P = 0.03).

Conclusions

These findings suggest that exercise training in accordance with the current national recommendations is effective in improving some health parameters in middle-age African American men who have a family history of type 2 diabetes, but did not have a significant impact on glycemic status.
Spo13 prevents premature cohesin cleavage during meiosis
Authors: Galander Stefan , Barton Rachael E. , Kelly David A. , Marston Adèle L.
Published: September 2019

Background:Meiosis produces gametes through two successive nuclear divisions, meiosis I and meiosis II. In contrast to mitosis and meiosis II, where sister chromatids are segregated, during meiosis I, homologous chromosomes are segregated. This requires the monopolar attachment of sister kinetochores and the loss of cohesion from chromosome arms, but not centromeres, during meiosis I. The establishment of both sister kinetochore mono-orientation and cohesion protection rely on the budding yeast meiosis I-specific Spo13 protein, the functional homolog of fission yeast Moa1 and mouse MEIKIN.

Methods:Here we investigate the effects of loss ofSPO13on cohesion during meiosis I using a live-cell imaging approach.

Results:Unlike wild type, cells lackingSPO13fail to maintain the meiosis-specific cohesin subunit, Rec8, at centromeres and segregate sister chromatids to opposite poles during anaphase I. We show that the cohesin-destabilizing factor, Wpl1, is not primarily responsible for the loss of cohesion during meiosis I. Instead, premature loss of centromeric cohesin during anaphase I inspo13Δcells relies on separase-dependent cohesin cleavage. Further, cohesin loss inspo13Δanaphase I cells is blocked by forcibly tethering the regulatory subunit of protein phosphatase 2A, Rts1, to Rec8.

Conclusions:Our findings indicate that separase-dependent cleavage of phosphorylated Rec8 causes premature cohesin loss inspo13Δcells.
Percursos para achar-se: os deslocamentos de Robert Smithson
Authors: Tietz Anelise
Published: September 2019

Este artigo discute a prática artística de Robert Smithson, com ênfase nas obras que apresentam deslocamentos, sejam físicos, sejam de trânsito entre espaço institucional e não-institucional, relacionando-os com uma experiência romântica, principalmente com a figura do flâneur. Entendemos que o deslocamento em Smithson busca uma experiência de individualidade e, portanto, intitulamos de percursos para achar-se.  Abstract This article discusses the artistic practice of Robert Smithson, with emphasis on the works that present displacements, whether physical or in transit between institutional and non-institutional space, relating them to a romantic experience, especially with the figure of the flâneur. We understand that Smithson's displacement seeks an experience of individuality, it is called "routes to find yourself".  Palavras-chave: Robert Smithson; Deslocamento; Flâneur; Arte Contemporânea.  Key-words: Robert Smithson; Displacement; Flâneur; Contemporary Art.
Referral for chest X-ray during pregnancy: considerations and concerns for the registered nurse referrer of medical ionising radiation
Authors: Ingram Shirley , Grehan Jennifer
Published: September 2019

In Ireland, nurse referral of medical ionising radiation has been in practice for 10 years. The chest X-ray is a key investigation for the patient who presents with acute chest pain. For nurses working in the specialty of cardiology, a knowledge of the risk/benefits of the chest X-ray is important for patient care. For the nurse referrer, it is vital to perform in a safe, competent and knowledgeable capacity and, as a cardiology nurse practitioner and referrer of chest X-ray, special consideration must be given to the pregnancy status of all female patients. This article aims to explain the physics of ionising radiation, radiation governance, the principles of X-ray referral and the potential harmful effects on the patient, with a specific focus on nurse referral in women of childbearing age.
Children's play must not be denied
Authors: Allingham Sue
Published: September 2019

Sue Allingham looks at current policy developments through the lens of the late, great, Vivian Gussin Paley to discover what the priorities for early childhood should be. Latest media coverage suggests there is much to challenge her principles.
Leaps towards learning
Authors: Blythe Sally Goddard
Published: September 2019

Daily movement, tailored to particular ages and groups of children, must be placed at the heart of the curriculum in order to support all aspects of learning, argues Sally Goddard Blythe.
A critical review of the literature on arthroscopic autologous matrix-induced chondrogenesis and matrix-assisted autologous chondrocyte transplantation for acetabular chondral defects
Authors: Naylor John P
Published: September 2019

Background/Aims

Significant acetabular chondral defects are a common clinical finding during hip arthroscopy, for which the current surgical management approach may be falling short. Autologous matrix-induced chondrogenesis and matrix-assisted autologous chondrocyte transplantation are two novel cell-regenerative therapies that offer a way to repair acetabular chondral defects.

Methods

A literature search of Cochrane, CINAHL, AMED and Medline (2007–2017) databases revealed seven relevant articles, but only four involved a hip arthroscopic approach.

Results

All included studies demonstrated some significant improvements in patient-reported outcomes for autologous matrix-induced chondrogenesis and matrix-assisted autologous chondrocyte transplantation. There appears to be a practical advantage in terms of cost and convenience for using one-step autologous matrix-induced chondrogenesis. However, over-reliance on one particular research team and use of small-scale retrospective studies constitutes low-level, non-generalisable evidence.

Conclusions

The literature does not convincingly support either of these new applications over and above any other currently available treatments. Further research is needed and should involve different centres, longer follow-ups and place a higher emphasis on methodological rigour in order to maximise the trustworthiness of results.
Electronic Structure and Spectral Study of Some Five Coordinate Complexes of Copper (II)
Authors: Kumar Birendra , Rani Rekha , Prasad Dayanand , Singh Praveen Kumar , Kumar Amit , Sharma Shivadhar
Published: September 2019

1-phenylazo-2-nephthol has been synthesized and used for complexation with Cu(II) metal ion along with pyridine, α-picoline, β- picoline, γ-picoline and water as secondary ligands. On the basis of elemental analysis and molar conductivity complexes were formulated as CuL2X [Where L is the prime ligand i.e 1-phenyl-azo-2-nephthol and X is the secondary ligand i.e. pyridine, α-picoline, β-picoline, and H2O.] The magnetic moment of these complexes (1.80 - 1.83 BM) indicates that these complexes are magnetically dilute. The appearance of 3 bands in the electronic spectra of complexes rules out the trigonal bipyramidal (D3h) symmetry arround Cu(II) ion in these complexes rather the electronic spectra favours square pyramidal (C4V) symmetry of these five coordinate complexes. The highest value of 10Dq clearly indicates the greater coordinating ability of α-picoline than pyridine, β-picoline and γ-picoline.
Infinite Latent Feature Selection Technique for Hyperspectral Image Classification
Authors: Miftahushudur Tajul , Ali Wael Chaeriah Bin , Praludi Teguh
Published: September 2019

The classification process is one of the most crucial processes in hyperspectral imaging. One of the limitations in classification process using machine learning technique is its complexities, where hyperspectral image format has a thousand band that can be used as a feature for learning purpose. This paper presents a comparison between two feature selection technique based on probability approach that not only can tackle the problem, but also improve accuracy. Infinite Latent Feature Selection (ILFS) and Relief Techniques are implemented in a hyperspectral image to select the most important feature or band before applied in Support Vector Machine (SVM). The result showed ILFS technique can improve classification accuracy better than Relief (92.21% vs. 88.10%). However, Relief can extract less feature to reach its best accuracy with only 6 features compared with ILFS with 9.
Design Analysis of Microstrip Rectangular Patch Array Antenna 16×1 on X-band Radar
Authors: Rahayu Soni Aulia , Suryana Joko , Tursilowati Laras , - Halimurrahman , Nugroho Ginaldi Ari
Published: September 2019

Radar has been widely used for various purposes such as monitoring atmospheric precipitation. For that purpose, it gives more accurate results than satellites do. Previous research has developed navigation radar that alters its functions into an atmospheric precipitation monitoring radar. To improve the development of the radar, an antenna system will be developed in this research. The purpose of developing this antenna is to obtain better data reception results. This antenna is a microstrip rectangular array antenna that works on X-band with a frequency of 9.41 GHz. Microstrip antenna is chosen since it has several advantages such as small dimensions and relatively low costs. The designed antenna gain ≥ 12 dB, bandwidth of 60 MHz, and horizontal polarization. Antenna fabrication produces a microstrip rectangular 16 x 1 array antenna using the mitered bend method at a frequency of 9.4 GHz with a reflection coefficient of -22.8 dB, VSWR of 1.2, gain of 13.21 dB, unidirectional radiation patterns and horizontal polarization.
Estilos parentais, competências sociais e o papel mediador da personalidade em adolescentes e jovens adultos
Authors: Mota Catarina Pinheiro , Ferreira Sara Duarte
Published: September 2019

As vivências afetivas experienciadas no seio familiar têm um papel privilegiado no desenvolvimento dos jovens. A presente investigação teve como objetivo analisar o efeito dos estilos parentais no desenvolvimento das competências sociais e testar o papel mediador da personalidade. A amostra incluiu 1976 jovens com idades entre os 14 e os 25 anos. Os resultados apontam que a empatia, a assertividade e o autocontrolo são preditos positivamente pelo estilo democrático e que a assertividade e o autocontrolo são preditos negativamente pelo estilo permissivo. Os dados sugerem o efeito mediador positivo da personalidade emocionalmente ajustada na associação do estilo democrático e as competências sociais, e um efeito mediador negativo entre o estilo permissivo e determinadas competências socias.
MANUSIA DALAM PANDANGAN YAHUDI
Authors: Darmaji Agus
Published: September 2019

This paper is divided into three sections. First, it gives a brief  introductory of the Jews. Second, it explains the process of  the creation of  human. Third, it elaborates the basis of  human behavior in the Jewish, like morality, suffering , and the ‘chosen people.’ In terms of  the creation of  human beings, Judaism states that human is made of the dust which is then fulfilled by the spirit through his nose. Human is created in God’s image. It is not only his soul, but also his body, represents the symbol of  God. The Hebrew Bible (Holy Book), in general, vastly embraces the doctrines of morality that should be used as the basis of  the behavior of  the Jews. This is particularly apparent from the teachings contained in the Ten Commandments. In addition, it also considers the chosen people as a liability, rather than an opportunity to obtain particular privileges; thus, they were elected to serve God and to undergo several sufferings in implementing the service.
KEBEBASAN EKSPRESI KEAGAMAAN DI JOGJA CITY OF TOLERANCE (STUDI KASUS TOLERANSI DAN INTOLERANSI DI BALIK PLANK “TERIMA KOST PUTRA MUSLIM/PUTRI MUSLIMAH”)
Authors: Muryana Muryana
Published: September 2019

Jogja City of Tolerance proceed approximately twelve years. But, discriminate based on religion still happen. On the one side it was human rights, but in the other side it taked another human rights. In the case of some boarding houses sometimes the owner put sentence such as “kost putri muslimah” in front of the homestay to informate someone who will rent. It can be assumtion that different religion couldn’t be the tenant for this boarding houses. Whereas city of tolerance could be assumed that the member of city had multiculturalism perspective. Parekh affirmed that significant aspect of multikulturalism was politic of recognition. Accordingly, this paper will answer two question: firstly, why sentence such as “kost putri muslimah” put in some boarding houses; secondly, how tolerance means in this context. The answer explanation of two questions above was got from interview and photo documentation of boarding houses in Sleman and Kota Yogyakarta. It analyzed using Parekh’s theory, politic of recognition in multiculturalism. Based on the research, result was got that the owner of boarding houses have several reasons put the sentence. Firstly, they had trauma with different etnicity. So, sensitivity of religion was used to safe. Secondly, they lived together with the tenant and they had education vision to the them. Therefore, tolerance has its context. The recognition to the other depends on their interest as the owner to keep their environtment. In this context human rights relates to other human rights in togetherness. Human right could do in general.
KAWASAN RELIGIUS DAN PRODUKSI RUANG DI LINGKUNGAN MASJID PATHOK NEGARA PLOSOKUNING YOGYAKARTA
Authors: Setiawan Rahmadi Agus
Published: September 2019

Study of religion and territory (space) is a new phenomenon in recent dec­ades along with the tendency of religious studies that change from normative to con­tex­tual approach. Plosokuning village as a religious area becomes research ob­ject that examines the relationship between religion and space. Furthermore, this re­search will explore how this religious region is formed and how it affects the beha­vior of the people in this village.This study uses a social theory known as the production of space proposed by Henri Lefebvre. In this theory, space is a social production, and always related to the social reality that surrounds it. Space never existed and manifested itself or held itself. In other words space has a historical dimension that helped shape it. The social space also influences the way of thinking and acting of society that exists in the space, as well as uses as control and domination.From the historical approach, it is found that the religious area of Plosokun­ing is a product of the palace (kraton Yogyakarta) that makes Plosokuning as a mutihan area (place of worship). This religious area is intended as a bastion of the spirituality of the palace and the implementation of the royal philosophy known as Kiblat Papat Lima Pancer. In this philosophy, the palace is in the middle and sur­rounded by a spiritual fortress in the form of four Pathok Negara Mosques, one of which is the Pathok Negara Mosque in Plosokuning.The religious area of Plosokuning, which is a palace product, has an influ­ence on the Islamic religiosity of the Plosokuning community. This religious beha­vior can be proved by the emergence of cultural products, both tangible and intangi­ble cultures. Tangible cultures are like the emergence of some boarding schools (pesantren), some musholla (small mosques), Muslim housing, and majelis ta'lim (place for Islamic studies). While intangible culture such as the emergence of Is­lamic art, religious rituals, as well as Islamic religious norms in society. Plosokun­ing as religious area continues to be inherited from generation to generation by continu­ing to revive the Islamic culture, both tangible and intangible culture.The study of the Plosokuning community also shows a strong relation be­tween religious space and the behavior of the people. By the existing of the reli­gious area,  so the sacred character of religion becomes strong in the environment of Pathok Negara Mosque Plosokuning. As a sacred area, it becomes a shame (ta­boo) when people conduct behavior or actions that violate Islamic norms and tradi­tions. The social function of this religion is also reinforced by giving social sanc­tions for people who violate the teachings of Islam. Keywords: Islam, production of space, sacred, Yogyakarta.
KONTEKSTUALISASI NILAI-NILAI LUHUR WARISAN LELUHUR DI ERA GLOBAL: BELAJAR DARI SERAT TRIPAMA DAN WAHYU MAKHUTA RAMA
Authors: Salehudin Ahmad
Published: September 2019

Heritage is a “blue print” that not only serves as guidance, but also a parameter for its heirs to live their lives. We must behave as we have "embodied" in the inheritance of the ancestors as they are. Heritage is often positioned as something that must not be changed, so changing it is considered inappropriate and immoral. Changing it can be considered as violating custom and destroying a taboo. Whereas if we look at the process of creation of ancestral heritage, then we will know that the creation of ancestral heritage tends to be accommodating and dynamic along with the times, such as the process of creating Serat Tripama and Wahyu Makhuta Rama. Through both of them, we know that the creation process of heritage is dynamic and accommodating.
Orientasi Agama Para Samanera dan Atthasilani di Vihara Dhammadipa Arama, Mojorejo, Kota Batu, Malang, Jawa Timur
Authors: Ningsih Alvista Fitri
Published: September 2019

Adapun judul tulisan ini adalah Orientasi Agama para Samanera dan Atthasilani di Vihara Dhammadipa Arama, Mojorejo, Kota Batu, Malang, Jawa Timur. Penelitian ini bertujuan untuk meneliti motif yang mendorong dan tahapan menjadi Samanera, Atthasilani melalui pendekatan psikologi agama menggunakan metode analisis Gordon W. Allport tentang orientasi intrinsik, ekstrinsik dan teori pendukung yaitu motivasi menjadi Samanera dan Atthasilani dalam pandangan agama Buddha serta Lawrence Kohlberg tentang tahapan perkembangan moral.Jenis penelitian penulis menggunakan metode kualitatif yaitu penelitian lapangan. Untuk metode pengumpulan data penulis yaitu observasi, wawancara, dan dokumentasi. Dari segi pengumpulan data, penulis melakukan observasi dengan mengamati gejala yang ada dalam objek penelitian serta wawancara dengan Bhikkhu Khanthidaro selaku Kepala Vihara Dhammadipa Arama, Bhikkhu Santacito, Samanera, Atthasilani, dan dokumentasi berupa buku-buku yang terkait dengan penelitian. Sedangkan pengolahan data penulis menggunakan analisis data yaitu dengan metode deskriptif.Data yang dianalisis adalah orientasi agama bagi Samanera dan Atthasilani. Hasil penelitian menunjukkan dua hal. Pertama, motif yang mendorong menjadi Samanera dan Atthasilani yaitu berasal dari kesadaran diri dan didorong dari keluarga, saudara, Guru, teman yang membuat semakin yakin menjalani kehidupan Samanera serta Atthasilani. Kedua, tahapan menjadi Samanera dan Atthasilani melalui tes yang diuji Bhikkhu dengan menghafal beberapa sila, lalu ditahbis menjadi Samanera dan Atthasilani dengan melalui prosesi cukur rambut dan pemakaian jubah. Pada saat menjalani kehidupan Samanera dan Atthasilani diberi penilaian dalam menerapkan 10 sila bagi Samanera ditambah 75 latihan tambahan dan 8 sila bagi Atthasilani untuk konsisten sampai lulus ke jenjang Bhikkhu maupun Atthasilani tetap.Kata kunci: Orientasi, agama, Samanera, Atthasilani.
PERAN KOMISI HUBUNGAN ANTAR UMAT BERAGAMA GEREJA KATOLIK DALAM MEMBANGUN DIALOG
Authors: Nur Hidayati M.Thoriqul Huda Dan
Published: September 2019

Dialog merupakan suatu tindakan yang mendasar dalam sebuah interaksi yaitu dengan cara berkomunikasi antara yang satu dengan yang lain bertemu dengan sesama. Dialog juga inti dasar dalam keutuhan NKRI, dasar dari keimanan, dari cerita ke cerita bahkan dapat terbentuk dalam kitab suci. Dalam hubungan antaragama tidak lepas dari dialog, karena sangatlah penting agar kita bisa saling membuka diri bahkan dialog adalah hal yang sangat wajib, sebab tanpa dialog kita tidak akan menemukan jalan keluar. Menurut orang katolik dialog ada dua inter religion yaitu non doktrin dan kebudayaan supaya dapat mengerti inti dari budaya. Perjumpaan dialog juga adanya hambatan hambatan yang terjadi, masih adanya pemikiran yang sangat sempit dan susah untuk terbuka dan solusi menghadapi hambatan-hambatan tersebut menggunakan hati. Tulisan memrupakan hasil riset lapangan atau riset kualitatif dengan menggunakan metode wawancara sebagai cara untuk memperoleh data di lapangan, focus objek kajian adalah komisi hubungan antar agama gereja Katolik. Dalam dialog adanya tiga tipe dalam beragam ekskulisf, inklusif, dan pluralis. Adapun dalam bentuk dalam membangun hubungan dialog antaragama terbentuklah sebuah komisi dalam gereja yang terdapat dalam dokumen konsili vatikan II sebagai landasan atau dasar dalam suatu komisi dan dipimpin oleh paus yang sebagai orang paling tinggi diturunkan kepada keuskupan. Keuskupan sendiri terbagi menjadi dua uskup lokal dan uskup metropolitan. Adapun beberapa kegiatan dalam komisi antara lain hubungan antar keagamaan, kerasulan awam, dan sosial.Kata Kunci: Komisi Hubungan Antar Umat Beragama, Dialog
La grande adaptation. Climat, capitalisme et catastrophe (R. Felli, 2016)
Authors: Elloué Nestor Engone
Published: September 2019

Recensé : Romain Felli, La grande adaptation. Climat, capitalisme et catastrophe, Paris, Le Seuil, 2016 (« Anthropocène »), 292 p.
On Margaret Benston
Authors: Federici Silvia
Published: September 2019

Margaret Benston's "The Political Economy of Women's Liberation" appears as both a return to the past and, at the same time, if not a "watershed," as described by Peter Custers, certainly a new turn. On the one hand, she reiterated the classic Marxist-Leninist argument concerning the precapitalist, premarket character of domestic work. On the other, she so strongly insisted on the importance of this work for the stability and perpetuation of the capitalist system that she not only anticipated some of the theses later argued by theorists in the Wages for Housework Campaign, but often fell into apparent contradictions.