bluuebunny/crossref_metadata_2025 huggingface dataset:
EVALUASI RASIONALITAS PENGGUNAAN OBAT ANTIHIPERTENSI PADA PASIEN PREEKLAMPSIA RAWAT INAP DI RSUD JEND. AHMAD YANI METRO PERIODE TAHUN 2019
Authors: Saputri Gusti Ayu Rai , Ulfa Ade Maria , Jannah Miftahul
Published: April 2022

Preeklampsia didefinisikan sebagai timbulnya hipertensi disertai dengan protein urin pada usia kehamilan lebih dari 20 minggu atau segera setelah persalinan, jadi pemilihan obat yang digunakan harus aman dan efektif, sehingga penelitian ini dilakukan untuk mengetahui jenis obat yang diberikan dan dipersentase rasionalitas penggunaan obat antihipertensi pada pasien preeklampsia Rawat Inap di RSUD Jend.ahmad Yani Metro Periode 2019. Penelitian ini merupakan jenis penelitian non eksperimental, karena tidak memberikan perlakuan apapun pada subyek penelitianya. Obat antihipertensi monoterapi yang digunakan pada preeklampsia ringan adalah golongan Agonis sentral α-2 yaitu methyldopa sebesar (100%) dan obat antihipertensi monoterapi yang paling sering digunakan pada preeklampsia berat adalah golongan Calsium Channel Bloker (CCB) yaitu nifedipin sebesar (48,48%). Sedangkan untuk kombinasi 2 obat yang banyak digunakan adalah Calsium Channel Bloker (CCB) nifedipin dan Agonis Sentral α-2 methyldopa sebesar (33,33%). Rasionalitas penggunaan obat antihipertensi berdasarkan Queensland Clinical Guideline (2015) dan POGI 2016 adalah 100% tepat diagnosis ; 83,33% tepat indikasi; 83,33% tepat obat; 100% tepat dosis; 100% tepat cara pemberian; 100% tepat interval waktu pemberia dan 100% tepat pasien, dengan nilai persentase kerasionalan penggunaan antihipertensi pada pasien preeklampsia adalah 95,23%. Kata kunci : Rasionalitas, Hipertensi, Preeklampsia, Rumah Sakit Ahmad yani
UJI AKTIVITAS PENURUNAN KADAR GLUKOSA DARAH EKSTRAK ETANOL KULIT JERUK NIPIS (Citrus aurantifolia) PADA TIKUS JANTAN SPRAGUE DAWLEY YANG DIINDUKSI ALOKSAN
Authors: Ulfa Ade Maria , Nofita Nofita , Bonita Berliana Nadila
Published: April 2022

Kulit jeruk nipis mengandung flavonoid, alkaloid, dan saponin yang diduga memiliki potensi sebagai antidiabetes. Flavonoid dan saponin dapat merangsang sel β pankreas untuk memproduksi insulin. Tujuan penelitian ini adalah mengetahui aktivitas penurunan kadar glukosa darah ekstrak etanol kulit jeruk nipis (Citrus aurantifolia) pada tikus sprague dawley yang diinduksi aloksan. Metode penelitian ini adalah pre and post control group design. Tiga puluh ekor tikus dibagi menjadi enam kelompok perlakuan. Kelompok I (kontrol normal) tanpa di induksi dan hanya diberi Na CMC 0,5%, kelompok II (kontrol negatif) di induksi aloksan dan diberi Na CMC 0,5%, kelompok III (kontrol positif) diberi glibenklamid 0,1mg/kg BB, kelompok IV, V dan VI diberi ekstrak etanol kulit jeruk nipis dengan dosis, 250mg/kg BB, 375mg/kg BB, dan 500mg/kg BB. Sebelumnya tikus diinduksi aloksan 150mg/kg BB secara intraperitonial, selama 4 hari. Pengukuran kadar glukosa pada tikus dilakukan selama 15 hari dengan 5 kali. Hasil uji LSD menunjukkan adanya perbedaan bermakna antara setiap kelompok dosis dengan kontrol negatif (p≤0,05) dan dosis ekstrak 500mg/kg BB tidak memiliki perbedaan yang bermakna dengan kontrol positif (p≥0,05).
FORMULASI GEL ANTI JERAWAT KOMBINASI EKSTRAK ETANOL DAUN KEMANGI (Ocimum x africanum Lour.) DAN LIDAH BUAYA (Aloe vera (L.) Burm. f.) BERBASIS SODIUM ALGINATE DAN UJI AKTIVITAS TERHADAP BAKTERI Propionibacterium acnes
Authors: Yasir Angga Saputra
Published: April 2022

Tanaman kemangi (Ocimum x africanum Lour.) dan tanaman  lidah buaya (Aloe vera (L.) Burm. f.) meupakan tanaman yang memiliki aktivitas antibakteri salah satunya dapat menghambat bakteri penyebab jerawat yaitu Propionibacterium acnes. Tanaman tersebut memilii kandungan senyawa metabolit sekunder diantaranya tanin, flavonoid, saponin, fenol, triterpenoid dan alkaloid. Penelitian ini betujuan untuk melihat formulasi sediaan gel kombinasi ekstrak daun kemangi dan lidah buaya terhadap bakteri Propionibacterium acnes. Penelitian diawali dengan uji pendahuluan kombinasi ekstrak daun kemangi dan lidah buaya dengan 3 seri konsentrasi dan melihat rata-rata luas zona hambat terbesar yang selanjutnya dibuat sediaan gel. Variansi daun kemangi yaitu 0,5%, 1% dan 1,5% kemudian lidah buaya 5%. Gel yang dibuat dengan formula kombinasi ekstrak daun kemangi 1,5% dan lidah buaya 5% dengan gelling agent sodium alginate. Zat tambahan alkohol, akuades, gliserin dan metil paraben. Evaluasi gel meliputi uji pH, organoleptis, homogenitas, daya sebar, daya lekat dan iritasi kulit. Analisis data digunakan uji Anova satu arah dilanjutkan uji tukey dengan taraf kepercayaan 95%. Hasil menunjukkan kombinasi ekstrak daun kemangi 1,5% dengan lidah buaya 5% merupakan kombinasi dengan luas rata-rata zona hambat terbesar.  Sediaan gel kombinasi ekstrak daun kemangi 1,5% dan lidah buaya 5% memiliki evaluasi gel yang memenuhi pesyaratan sifat fisik gel dan mampu menghambat bakteri Propionibacterium acnes dengan luas rata-rata zona hambat yaitu 2,52 mm.
Review artikel: Aktivitas Antioksidan Ekstrak Daun Kelor (Moringa oleifera Lam.)
Authors: Satriyani Desak Putu Putri
Published: April 2022

Keberadaan radikal bebas memicu terjadinya arterosklerosis, penyakit jantung koroner, stroke, kanker, gagal ginjal, dan proses penuaan pada manusia. Senyawa yang berperan dalam menangkap radikal bebas disebut sebagai antioksidan. Antioksidan merupakan senyawa yang menyumbangkan elektron tunggal atau atom hidrogen untuk menstabilkan radikal bebas. Sumber antioksidan alami dapat diperoleh dari tanaman. Salah satu tanaman yang dimanfaatkan aktivitasnya sebagai antioksidan yaitu daun kelor (Moringa oleifera Lam). Ekstrak daun kelor mempunyai aktivitas antioksidan karena mengandung senyawa flavonoid dan beta karoten. Tujuan artikel review ini adalah untuk mengetahui potensi antioksidan yang terdapat dalam daun kelor. Review artikel ini dibuat menggunakan metode studi literatur ilmiah menggunakan pustaka yang berasal dari jurnal nasional, jurnal internasional, seminar nasional ilmiah, dan buku ilmiah yang diterbitkan selama sepuluh tahun terakhir melalui proses pencarian pustaka terkait aktivitas antioksidan ekstrak daun kelor. Berbagai penelitian terdahulu menunjukkan bahwa ekstrak daun kelor berpotensi sebagai antioksidan alami karena mengandung senyawa yang memiliki aktivitas antioksidan yaitu flavonoid dan beta karoten.
UJI AKTIVITAS ANTIOKSIDAN EKSTRAK KULIT BUAH KOPI ROBUSTA (Coffea canephora Pierre ex A.Foehner) DALAM SEDIAAN KRIM
Authors: Winahyu Diah Astika , Marcellia Selvi , Diatri Melati Intan
Published: April 2022

Kulit buah kopi robusta (Coffea canephora Pierre ex A. Foehner) merupakan limbah yang dapat dimanfaatkan sebagai antioksidan.Tujuan dari penelitian ini adalah untuk mengetahui adanya aktivitas antioksidan pada limbah kulit buah kopi robusta dalam sediaan krim dan untuk mengetahui konsentrasi yang paling efektif digunakan untuk kulit. Ekstraksi dilakukan dengan metode maserasi dengan menggunakan etanol 96% pada suhu ruang, diperoleh ekstrak kental 19,57%. Hasil uji fitokimia menunjukkan bahwa ekstrak kulit buah kopi robusta mengandung senyawa flavonoid, alkaloid, tannin, dan saponin. Sediaan krim dibuat menggunakan variasi konsentrasi ekstrak pada formula I, II, dan III (0,8%, 1,6%, dan 2,4%). Krim ekstrak kulit buah kopi robusta tipe M/A telah memenuhi syarat uji organoleptis, pH, homogenitas, daya sebar, tipe krim, daya tercuci, stabilitas dan iritasi.Aktivitas antioksidan ditentukan dengan metode DPPH yang memiliki prinsip penurunan nilai absorbansi yang sebanding dengan kenaikkan konsentrasi senyawa antioksidan yang dinyatakan dalam IC50. Hasil IC50 yang diperoleh pada ekstrak yaitu 72,96 ppm, dan pada krim 153,38 ppm, 149,77 ppm, dan 149,44 ppm. Formula III merupakan formula terbaik yang mendekati nilai aktivitas antioksidan kontrol positif yaitu 125,29 ppm. Aktivitas antioksidan ekstrak tergolong kuat (50-100 ppm), FI tergolong lemah (150-200 ppm), FII,FIII dan kontrol positif tergolong sedang (100-150 ppm).
Hubungan Pola Makan Dengan Kejadian Hipertensi Pada Lansia Di UPTD Panti Sosial Tresna Werdha Kecamatan Natar Lampung Selatan
Authors: Mustofa Festy Ladyani , Hasbie Neno Fitriyani , Roynaldo Muhammad Dwi
Published: April 2022

ABSTRACTOne of the risk factors for hypertension is diet. Some of the risky food eating behaviors that cause hypertension are frequent eating salty foods, often eating sweet foods and often eating fatty foods. The condition of the risky food behavior in the elderly community increased its percentage from 2007 to 2013, only the behavior of eating sweet foods decreased 9.4%, while the eating behavior increased sharply by 1.7%. Purpose to see the relationship between diet and the incidence of hypertension in the elderly at the Tresna Werdha Social Home, Natar Lampung Selatan Subdistrict in 2020. The type of research used in this study was quantitative with a cross sectional design. The sample used in this study was the elderly at the UPTD Tresna Werdha Social Institution, Natar Lampung Selatan District in 2020. Data analysis used the Chi-Square Test. The results of the chi square test for the relationship between diet and the incidence of hypertension obtained a significance value / p-value of 0.000 with an odds ratio of 14.250. There is a relationship between diet and the incidence of hypertension in the elderly in the UPTD Tresna Werdha Social Institution, Natar Lampung Selatan Subdistrict in 2020. If someone has a bad diet, that person is at risk of developing hypertension 14,250 times higher than those who have a good diet Keywords: Hypertension, Diet, ElderlyABSTRAK Faktor risiko dari hipertensi salah satunya adalah pola makan. Beberapa perilaku makan-makanan yang berisiko yang menyebabkan hipertensi adalah sering makan makanan asin, sering makan makanan manis dan sering makan makanan berlemak. Kondisi perilaku makan makanan berisiko pada komunitas lansia terjadi peningkatan presentasenya dari tahun 2007 ke tahun 2013, hanya pada perilaku makan- makanan manis yang terjadi penurunan 9,4 %, sedangkan pada perilaku makan makanan asin meningkat tajam sebesar 1,7 %. Untuk mengetahui hubungan pola makan dengan kejadian hipertensi pada lansia di UPTD Panti Sosial Tresna Werdha Kecamatan Natar Lampung Selatan tahun 2020. Jenis penelitian yang digunakan dalam penelitian ini adalah kuenatittatif dengan desain cross sectional. Sampel yang digunakan pada penelitian ini adalah lansia di UPTD Panti Sosial Tresna Werdha Kecamatan Natar Lampung Selatan tahun 2020. Analisa data menggunakan Uji Chi-Square. Hasil uji chi square hubungan antara pola makan dengan kejadian hipertensi didapatkan nilai signifikansi/p-value sebesar 0,000 dengan nilai odd ratio sebesar 14,250. Terdapat hubungan pola makan dengan kejadian hipertensi pada lansia di UPTD Panti Sosial Tresna Werdha Kecamatan Natar Lampung Selatan Tahun 2020. Apabila seseorang memiliki pola makan yang buruk maka orang tersebut beresiko mengalami hipertensi 14,250 kali lebih tinggi dibandingkan dengan mereka yang memiliki pola makan yang baik Kata Kunci     : Hipertensi, Pola Makan, Lansia
L’enseignement de l’histoire de l’Holocauste2 et l’éducation aux droits humains : pratiques et enjeux au Québec
Authors: Moisan Sabrina
Published: April 2022

This article focuses on the twinning of history teaching and human rights education. The case of the Holocaust illustrates the possibilities and limits of such a relationship, in light of the practices implemented in history and citizenship education classes in Quebec. Organized around four axes of analysis, the results show that teaching practices privilege above all an awareness to the human rights and are therefore centered on the knowledge of the rights. Similarly, the teaching of the Holocaust focuses on the Nazi efforts to persecute Jews without explicit references to human rights issues, which is how the curriculum prescribes it. Both subjects are therefore studied separately in the same sequence.
Concept of controlling in the process of generating strategic information
Authors: Levitsky S.
Published: April 2022

The article critically analyzes the literature and finds that the definition of the term «controlling» combines two components: controlling as a philosophy and controlling as a tool. It is proved that the main purpose of controlling is to focus the management process on achieving the objectives of financial and economic activities of the enterprise and information support of related management decisions. The main differences between strategic and operational controlling are given. The place of controlling in the enterprise management system has been determined, therefore the controlling system should be appropriate and operative, as the speed of making managerial decisions affects the efficiency of the enterprise. It is proved that the decision-making process based on the indicators of the controlling system is inextricably linked with the speed of the process itself and responding to changes in the internal and external environment of the enterprise. The controlling system must be continuous in time (characterized by repeatability of elements) and multi-stage. It is determined that one of the most significant differences between controlling and accounting is the direction of its information flow. In the process of implementation of all stages of controlling it is important to use the following tools: the formation of «fair value» of the entity; budgeting of the enterprise as its stages and all activities in general; use of a system of balanced scores; receiving, processing, transmitting, storing and displaying information to make effective management decisions by means of accounting; control over the effectiveness of socially responsible activities. When developing a business management system, it is necessary to give a key role to the quality of information received, the speed of its formation and transmission, as it is the basis for decision-making. The main source of such information is reporting, auxiliary – the entire database of the enterprise and formed on its basis financial, tax and statistical reporting. The information in the controlling system is cyclical and its main source is accounting and information support in the form of accounting documents.
Main directions of development of modern commodity science
Authors: Vasiuta V. , Puzak V. , Lashko I.
Published: April 2022

The article examines the main directions of development of commodity science in modern conditions. Currently, the volume of consumer goods on the market has increased significantly. The breadth of the assortment of goods, their colorful design, a variety of forms, the presence of various markings forced trade specialists to study the consumer properties of the goods more carefully. The authors note the fact that with the change in economic and social conditions, some problems become urgent again. This leads to the emergence of new requirements for the quality of goods, their packaging, identification for disclosure or prevention of counterfeiting. In modern conditions, merchandising should be an applied science, not an academic one. The article defines the essence of commodity science as a science, outlines its main goals and objectives at the present stage of development of a market economy. Commodity science is a science that systematically studies different stages of the life cycle of goods, a method for understanding their use value, classification of goods, demand for production, turnover and consumption. Commodity science gives an understanding of all those changes that occur in a product at all stages of its movement, allows you to predict its competitiveness. Commodity science as a science about a commodity pays great attention to the issue of quality. Various goods. having the same purpose, can meet the needs of consumers in different ways. That is why it is important to study the consumer characteristics of goods. To determine the consumer characteristics of goods, you need to use commodity expertise. The main purpose of the examination is to obtain reliable information about the object. The process of identifying goods is important to detect or prevent counterfeiting. Product identification is an important step in assessing quality and determining whether the product meets the standards or requirements specified in regulatory or other documents. Today, the issue of compliance with the requirements of containers and packaging is relevant. The authors note that packaging is necessary not only to give an aesthetic appearance to the product, but also to protect it during transportation and storage. Nowadays, the problem of sorting and recycling plastic containers and packaging is a painful one.
Branding Al Ain as a tourist destination
Authors: Longart Pedro , Iankova Katia
Published: April 2022

This paper focuses on developing a tourist destination in the UAE, alongside the Sustainable Development Goals of increasing work opportunities and economic growth. The UAE has long recognised the importance of tourism for developing its economy. Abu Dhabi registered five sites in the UNESCO list of global heritage in 2011, and one of these sites is in the Oasis city of Al Ain. There is a potential for Al Ain to grow as a tourist destination, as part of the UAE nation brand. The research approach is mainly quantitative, using marketing research techniques such as Discrete Choice Analysis and Max-Diff to ascertain consumer preferences. The present study uses the 178 online questionnaires completed out of about 350 respondents. The findings of this study pose several practical implications. In the first place, it will determine how Al Ain can fit within a brand architecture of the Abu Dhabi Emirate or the UAE nation brand. Secondly, it can shed light on brand associations and the brand identity that Al Ain must pursue. It is considered that this piece of research can contribute to the development of Al Ain as a tourist destination and help organisations such as Abu Dhabi Department of Tourism and Cultural with the promotional messages and the positioning of Al Ain.
Antecedents of QR code acceptance during COVID-19: Towards sustainability
Authors: Varadarajan Sowmya Damodharan , Asraar Ahmed K. A.
Published: April 2022

This study’s primary goal is to determine that investment in entrepreneurship education is vital as it will help in new venture creation and identify future leaders with an entrepreneurial mindset. The research aims to examine whether there is an interest and awareness in the entrepreneurial intentions among female Emirati students studying in the UAE. The study also tries to find any differences in the different curricula that impact their preferences in the UAE. This study’s conceptual framework primarily relies on the existing Theory of Planned Behavior (TPB). This research is an empirical study the results and analysis are from the survey data of 490 Emirati female students in HCT higher education in the UAE. This study and the research analysis show the various factors: Attitude, Subjective Nom, PerceivedBehavioral Control, Family Background, Level of Awareness, and Knowledge of the student, have the most significant impact on Entrepreneurship Intention to become future Entrepreneurs. All three core constructs of the Theory of Planned Behavior substantially affect entrepreneurship intention. The Subjective Norm has an inverse relationship (negatively significant) with Behavioral Intention, which indicates that the respondents’ peers in this study are against entrepreneurship. This paper is unique because it gives a glimpse of the new innovative ways the next generation of students will think about business models during and after the COVID-19 pandemic. These new business models and approaches will have a more significant impact. Entrepreneurship intentions will be a deciding factor for the next generation of leaders in the UAE.
Revenue management during the COVIDization of the economy
Authors: Radev Radko , Yankova Veselina
Published: April 2022

The purpose of this article is to prove the need to perceive revenues as a manageable variable by applying an active approach to companies’ management during the COVIDization of the economy. In this regard, the article illustrates the role of revenues as a factor and as a result. Revenues underlie the formation of all major financial indicators. They are key measures of a company’s growth and performance. This dual nature of revenues is revealed in the context of economics, accounting and financial management. Their importance determines the need to adopt an active approach to revenue management of the economy during COVID-19 pandemic or other similar future occurrences. From a theoretical point of view, the active approach has been justified in the context of the classical strategic management methods emphasising the leading role of marketing. The main research hypothesis tested is that in the conditions of a sharp change in the economy during COVIDization, the importance of the active approach of operating revenue management as the main variable (KPI), cannot be understated.
Influenza epidemiology in patients admitted to sentinel Australian hospitals in 2019: the Influenza Complications Alert Network FluCAN
Authors: Cheng Allen C , Dwyer Dominic E , Holmes Mark , Irving Louis B , Simpson Graham , Senanayake Sanjaya , Korman Tony , Friedman N Deborah , Cooley Louise , Wark Peter , Holwell Anna , Bowler Simon , Upham John W , Fatovich Daniel M , Waterer Grant W , Macartney Kristine , Blyth Christopher C , Crawford Nigel , Buttery Jim , Marshall Helen S , Clark Julia E , Francis Joshua , Kotsimbos Tom , Kelly Paul M
Published: April 2022

Influenza is a common cause of acute respiratory infection, and is a major cause of morbidity and mortality. This report summarises the epidemiology of hospitalisations with laboratory-confirmed influenza during the 2019 influenza season. The Influenza Complications Alert Network (FluCAN) is a sentinel hospital-based surveillance program that operates at sites in all jurisdictions in Australia. Cases were defined as patients hospitalised at any of the 17 sentinel hospitals with influenza confirmed by nucleic acid detection. Data were also collected on a frequency matched control group of influenza-negative patients admitted with acute respiratory infection. During the period 1 April to 31 October 2019 (the 2019 influenza season), there were 4,154 patients admitted with confirmed influenza to one of 17 FluCAN sentinel hospitals. Of these, 44% were elderly (≥ 65 years), 21% were children (< 16 years), 7.7% were Aboriginal and Torres Strait Islander peoples, 1.7% were pregnant and 73% had chronic comorbidities. Most admissions were due to influenza A infection (85%). Estimated vaccine coverage was 75% in the elderly, 49% in non-elderly adults with medical comorbidities, and 27% in young children (< 5 years). The estimated vaccine effectiveness in the target adult population was 42% (95% confidence interval [95% CI]: 36%, 49%). There were a larger number of hospital admissions detected with confirmed influenza in this national observational surveillance system in 2019 than in 2018.
An outbreak of leptospirosis associated with cattle workers during the wet season, in the Northern Territory of Australia, 2021
Authors: Brown Damien R , Peiris Ruwani , Waller Claire , Stedman Elizabeth M , Fitzpatrick Susanne E , Krause Vicki L , Draper Anthony DK
Published: April 2022

An outbreak of leptospirosis occurred in the Top End of the Northern Territory, Australia, during the wet season in early 2021. There were 14 outbreak cases; most were male (12/14; 86%) and nonIndigenous (13/14; 93%) with a median age of 22 years (range 19–52 years). We conducted a descriptive case series to investigate the outbreak. We determined that the outbreak was most likely due to higher than usual rainfall in a workplace with exposure to cattle, heightened by wearing clothing and footwear which offered little protection, with limited use of personal protective equipment (PPE). Increased and ongoing education for cattle industry workers, and promotion of the use of appropriate clothing and PPE, may minimise the risk of future outbreaks. Australia’s national surveillance case definition for leptospirosis should be reviewed to incorporate the use of nucleic acid testing in the detection of leptospirosis.
Penerapan Media Interaktif Power Point untuk Meningkatkan Aktivitas dan Hasil Belajar Siswa Kelas VI Tema 8 SDN Prantaan Kabupaten Blora
Authors: Wahyuningsih Sustiana
Published: April 2022

The purpose of this study was to increase student activity and learning outcomes by using interactive media Power Point for students of Class VI Theme 8 at SDN Prantaan. The research method used is Classroom Action Research (CAR) consisting of 3 cycles with 4 stages, namely planning, action, observation, and reflection. The subjects of this study were students of class VI with a total of 30 students. Data collection techniques used are observation, interviews, tests, and documentation. While the data analysis technique used descriptive analysis. The results of this study indicate that the average percentage of student activity classically has increased. In the pre-cycle before treatment it was 65%, in the first cycle it was 69%, in the second cycle it was 74% while in the third cycle it was 87%. While the percentage of mastery learning outcomes in the pre-cycle is 33%, in the first cycle it is 33%, in the second cycle it is 73%, while in the third cycle it is 90%. Based on the results of the research that has been done, it can be concluded that learning in Theme 8 using interactive power point media can improve student activities and learning outcomes.
Penerapan Metode Pembelajaran Kooperatif Student Team Achievment Division untuk Meningkatkan Motivasi dan Hasil Belajar Siswa di SMA Negeri 1 Tanjung
Authors: Astawa I Nyoman Budhi
Published: April 2022

This study aims to improve student motivation and learning outcomes at SMA Negeri 1 Tanjung. through the application of the Student Team Achievment Division (STAD) learning method. This research method used classroom action research which is carried out in two cycles, each cycle consisting of planning, implementation, observation, and reflection stages. The data collection technique in this study used observation sheets, questionnaires and tests. The data analysis technique of this research used descriptive qualitative and quantitative analysis. The results showed that: in the pre-cycle student learning mastery was 70%, in the first cycle student learning motivation was 78.12%, for teacher activities it was 79.16%, while for classical learning completeness it was 72.72%, while in the second cycle learning motivation was students increased to 84.37%, for teacher activity increased to 83.33%, while for classical learning completeness increased to 87.87%. So with these results it can be concluded that through the application of the Student Team Achievment Division (STAD) method can increase student motivation and learning outcomes.
Pediatric Minor Traumatic Brain Injury : Growing Skull Fracture, Traumatic Cerebrospinal Fluid Leakage, Concussion
Authors: Choi Jong-Il , Kim Sang-Dae
Published: April 2022

Traumatic brain injury (TBI) is a major public health issue that causes significant morbidity and mortality in the pediatric population. Pediatric minor TBIs are the most common and are widely underreported because not all patients seek medical attention. The specific management of these patients is distinct from that of adult patients because of the different physiologies in these age groups. This article focuses on minor TBIs, particularly growing skull fractures, traumatic cerebrospinal fluid leakage, and concussion.
Larvicidal Activity and Histopathological Midgut Alteration of Aedes Aegypti Larvae Induced by Methanol Extract Mahkota Dewa fruit (Phaleria Macrocarpa (Scheff). Boerl)
Authors: Eliza Nurul , Subahar Rizal , Aulung Agus
Published: April 2022

Aedes aegypti is the main vector of DHF in Indonesia. The use of synthetic insecticide results in vector resistance. Mahkota Dewa fruits (Phaleria macrocarpa (Scheff) Boerl) contain flavonoids, saponins, and tannins. Thus, it has the potential as a natural larvicide against Ae. aegypti larvae. The objective of the study was to determine the effectiveness of methanol extract Mahkota Dewa fruit. This research was experimental, used methanol extract Mahkota Dewa fruit at concentration 0.1%, 0.15%, 0.20%, 0.25% and 0.30%, then added 25 larvae each concentration and repeated 3 times. After 24 and 48 hours of exposure, the mortality of larva was counted and then calculated LC50 and anterior midgut histopathology. LC50 values 0,554% (0,391-11,397) and anterior midgut histopathology shows epithelial damage. Mahkota Dewa fruits with methanol extract have activity as larvicide larvae instar III-IV Ae. aegypti.
The Effect Of Progressive Muscle Relaxation Technique (PMRT) On The Quality Of Life Of Third Trimester Pregnant Women At Public Health Centre II, West Denpasar District
Authors: Aswitami Ni Gusti Ayu Pramita , Surya Darma I Gusti Gede Mayun , Maryani Ardi Ni Made Septiari
Published: April 2022

Pregnancy impacts a women’s physical and mental state. These modifications will have an impact on pregnant women’s quality of life. Pregnant women’s poor quality of life will impact the fetus and mother’s health. As a result, nonpharmacological therapy, such as the use of progressive muscle relaxation techniques (PMRT), is required to improve the quality of life of pregnant women. PMRT research has so far been linked to anxiety and depression in pregnant women that it is still limited in its application to the quality of life of pregnant women in the third trimester. This study aims to see how beneficial PMRT is in improving the quality of life of pregnant women. A quasi-experimental approach with a pre-post test with Nonequivalent Control Groups is used in this investigation. With a total sample size of 46 participants, non-probability sampling was used to pick the sample. Questionnaires are used to collect data, and t-independent analysis is used to analyze it. There were p-value 0.05 variations in the quality of life of pregnant women in the control and treatment groups after receiving PMRT. The average improvement in quality of life in the control and treatment groups was significantly different (p-value 0.05). For each dimension, there was a significant difference in the quality of life between the control and intervention groups before and after the research (p-value). It is expected that health workers will provide PMRT in pregnancy health services to improve the quality of life of pregnant women.
Prevalence, severity, and self-management of depressive mood among community-dwelling people with spinal cord injury in Nepal
Authors: Baniya Mandira , Kitrungrote Luppana , Damkliang Jintana
Published: April 2022

Background: Depression is a common psychological condition after spinal cord injury. There are increased incidences of self-harm, suicidal behavior, and lower quality of life among people with spinal cord injury and depression. However, self-management of depressive symptoms in the community is less explored.
Objective: This study aimed to examine the prevalence, severity, and self-management of depressive mood in community-dwelling people with spinal cord injury.
Methods: A descriptive study was conducted in 2019 among 115 people with spinal cord injury discharged from three health centers and living in the 13 districts of Bagmati Province. Participants were selected using stratified random sampling. Questionnaires were related to demographics, health and environment, depressive mood, and self-management. Descriptive statistics and quantitative content analysis were used to analyze the data.
Results: Ninety-seven (84.3%) people with spinal cord injury had a depressive mood. Of these, 60.8% had moderate to severe depressive moods. They mainly used the internet and social media, shared feelings with family members, and practiced Hindu religious activities for depressive mood management because of the physical barriers to accessing a healthcare facility and easiness to use of non-pharmacological methods. Nearly half of participants who used sharing of feelings felt their depressive mood disappeared when they often used the method.
Conclusion: Depressive mood following initial hospitalization is highly prevalent among people with spinal cord injury in Nepal, most of whom live in rural settings. Therefore, nurses and other health professionals should provide psychoeducation for this population and their family members to better address mental health problems. Facilitating pathways for those in rural areas to engage in social activities and timely treatment access may improve depressive mood. Nurses and other rehabilitation professionals can use social media to assess depressive moods and deliver management approaches in the community.
Reusable Extractant and Direct Catalytic Mediation of Water/Oil/Chlorodifluoromethane Nano-Emulsion in Natural Gas Condensate for Efficient Conversion of Chloride Impurities Into the Dicopper Chloride Trihydroxide Nanoparticles
Authors: Banan Khorshid Zohre , Doroodmand Mohammad Mahdi
Published: April 2022

This research introduces an oil-in-water (O/W) nano-emulsion (oil-water-CHClF2) as the reusable extractant phase using liquid–liquid extraction methodology for the removal efficiency of Cl− and Hg(0) [between 90% and ∼100%, deepening on the nature of the natural gas condensate (NGC)] at a brief separation time (<3.0 min). The achieved safety of the NGC using this nano-emulsion results in efficient reduction in the corrosion rate during testing iron-based fragments (vs. the untreated ones as controls) and increase in the NGC economic value. Another advantage of the synthesized nano-emulsion is its capability and catalytic mediating behavior to efficiently separate and synthesize highly pure dicopper chloride trihydroxide nanoparticles. The synthesized nanoparticles were characterized by different analytical methods such as Fourier transform infrared spectrometry, X-ray diffraction, X-ray photoelectron spectrometry, and direct visualization by some electron microscopies. Direct synthesis, fast synthetic time (<3.0 min), high purity (>99%), and scalability are the main advantages of this synthetic method. This nanoparticle is not only safe but also is efficiently applicable in different industries, especially as an eco-friendly agricultural pesticide for different plants and tress such as pistachio. Consequently, this method is accepted as direct, simple, low-cost, and scalable conversion of some upstream industries with the downstream ones. All these possibilities are attributed to the intermediate transport properties of the introduced O/W nano-emulsion. At this condition, this reagent plays role as a recycled motor for the NGC purification and conversion of these impurities into the safe and usable products. To the best of knowledge, this research is considered as the first report that shows application of this O/W medium for both chloride and mercury removal from the NGC and its direct use as top element in the synthesis of eco-friendly nanoparticles. This system is applicable in some parts of the fuel and oil centers of the “Middle East.”
The “Right” Definition for Post–Left Ventricular Assist Device Right Heart Failure: The More We Learn, the Less We Know
Authors: Hall Shelley A. , Copeland Hannah , Alam Amit , Joseph Susan M.
Published: April 2022

Right heart failure is a major cause of morbidity and mortality following left ventricular assist device implantation. Over the past few decades, the definition proposed by the Interagency Registry of Mechanical Circulatory Support and Society of Thoracic Surgeons has continually evolved to better identify this complex pathology. We propose that the latest definition proposed by the Mechanical Circulatory Support Academic Research Consortium in 2020 will increase our recognition and understanding of this complex disease phenomenon.
Towards a Digital Twin of the Earth System: Geo-Soft-CoRe, a Geoscientific Software & Code Repository
Authors: DeFelipe Irene , Alcalde Juan , Baykiev Eldar , Bernal Isabel , Boonma Kittiphon , Carbonell Ramon , Flude Stephanie , Folch Arnau , Fullea Javier , García-Castellanos Daniel , Geyer Adelina , Giralt Santiago , Hernández Armand , Jiménez-Munt Ivone , Kumar Ajay , Llorens Maria-Gema , Martí Joan , Molina Cecilia , Olivar-Castaño Andrés , Parnell Andrew , Schimmel Martin , Torné Montserrat , Ventosa Sergi
Published: April 2022

The immense advances in computer power achieved in the last decades have had a significant impact in Earth science, providing valuable research outputs that allow the simulation of complex natural processes and systems, and generating improved forecasts. The development and implementation of innovative geoscientific software is currently evolving towards a sustainable and efficient development by integrating models of different aspects of the Earth system. This will set the foundation for a future digital twin of the Earth. The codification and update of this software require great effort from research groups and therefore, it needs to be preserved for its reuse by future generations of geoscientists. Here, we report on Geo-Soft-CoRe, a Geoscientific Software & Code Repository, hosted at the archive DIGITAL.CSIC. This is an open source, multidisciplinary and multiscale collection of software and code developed to analyze different aspects of the Earth system, encompassing tools to: 1) analyze climate variability; 2) assess hazards, and 3) characterize the structure and dynamics of the solid Earth. Due to the broad range of applications of these software packages, this collection is useful not only for basic research in Earth science, but also for applied research and educational purposes, reducing the gap between the geosciences and the society. By providing each software and code with a permanent identifier (DOI), we ensure its self-sustainability and accomplish the FAIR (Findable, Accessible, Interoperable and Reusable) principles. Therefore, we aim for a more transparent science, transferring knowledge in an easier way to the geoscience community, and encouraging an integrated use of computational infrastructure.

Systematic Review Registration: https://digital.csic.es/handle/10261/193580.
General and Central Obesity Are Associated With Increased Severity of the VMS and Sexual Symptoms of Menopause Among Chinese Women: A Longitudinal Study
Authors: Tang Ruiyi , Fan Yubo , Luo Min , Zhang Duoduo , Xie Zhuolin , Huang Feiling , Wang Yuchen , Liu Gaifen , Wang Yaping , Lin Shouqing , Chen Rong
Published: April 2022

Background

Strong evidence has linked overweight and obesity to increased risks of cardiovascular disease and all-cause mortality in Chinese populations. Menopause is considered associated with increased obesity and central body fat distribution. However, the correlation between obesity and menopausal symptoms has not been well studied.

Objective

To examine the associations between obesity or abdominal obesity and menopausal symptoms as women progressed from premenopausal to postmenopausal status.

Design

This study included 430 midlife Chinese women who had experienced natural menopause and were followed up for 10 years. Physical examinations and questionnaires should be completed annually. The questionnaires include the Menopause-Specific Quality of Life questionnaire, the Hospital Anxiety and Depression Scale, and other physical and behavioral factors.

Results

Among women who were not obese (n=345) or not abdominal obese (n=372) at baseline, 5.8% and 31.7% became obese or abdominal obese at the recent follow-up visit, respectively. Women at the recent follow-up visit had an increased body mass index (BMI) by 0.14%, and the waist-to-hip ratio (WHR) increased by 5.2% compared with the data at baseline. In multivariate analysis, more frequent hot flashes, moderate/severe bothered vasomotor symptoms (VMS), mild bothered sexual functioning, and less anxiety symptoms were significantly associated with obesity. Increasing age, moderate/severe bothered VMS, and less anxiety symptoms were independently associated with abdominal obesity. Multivariable analysis also showed that less education level is independently associated with both obesity and abdominal obesity.

Conclusion

Our findings suggest that the proportion of obesity and abdominal obesity increased gradually during menopause. The increase of abdominal obesity is more rapidly than obesity in middle-aged women. Both obesity and abdominal obesity are related with severe or frequent VMS and anxiety symptoms in Chinese women. Although the proportion of obese women in China is lower than in western countries, the problem of abdominal obesity and related complications cannot be ignored.
The Dynamic Impact of Financial Globalization, Environmental Innovations and Energy Productivity on Renewable Energy Consumption: Evidence From Advanced Panel Techniques
Authors: Majeed Abdul , Ahmad Mahmood , Rasheed Muhammad Faisal , Khan Muhammad Kaleem , Popp József , Oláh Judit
Published: April 2022

Attaining cleaner production is a major challenge for BRICS economies. In this context, this study explores the effect of financial globalization on renewable energy consumption in BRICS economies from 1990 to 2018. It is probably the first research to study the linkage between financial globalization and renewable energy consumption. Therefore, this research adds to the current literature by presenting new empiric evidence on how financial globalization, in conjunction with environmental innovations, energy productivity, energy prices, and economic growth, affect renewable energy consumption in BRICS economies. In doing so, this research utilized novel econometric methods such as continuously updated fully modified (CUP-FM) and continuously updated bias-corrected (CUP-BC) techniques to evaluate the long-run results. The empirical findings show that financial globalization, environmental innovation, energy productivity, and energy prices promote renewable energy consumption. In contrast, economic growth impedes renewable energy consumption. This study suggests that governments and policymakers in BRICS countries should consider financial globalization and the increasing role of environmental innovations to increase the renewable energy share, which can be the appropriate solutions to the environmental challenges and achieve the Paris Climate Agreement’s goals. BRICS economies require speeding up permits for renewable energy projects, raising tax credits, including substantially more grants and loans, extending timelines for pandemic-affected projects, and investing directly in emerging clean energy sources.
Forecast of China’s Annual Carbon Emissions Based on Two-Stage Model
Authors: Zhang Xiaolei , Xiong Jingbo , Song Jianqi
Published: April 2022

China’s carbon emissions are a major global concern. China has proposed a defined “dual-carbon” aim, with the first target being to attain the carbon emissions peak by 2,030. To address this issue, this study provides a two-stage method for forecasting China’s annual carbon emissions, which is paired with pertinent carbon emissions data to predict China’s annual carbon emissions. We discovered the associated aspects affecting China’s carbon emissions through the research of this article, and we predicted the carbon emissions data from 2017 to 2020 using the two-stage technique based on these factors. When compared to the actual data of China’s annual emissions from 2017 to 2020, the prediction intervals from this method encompass the actual data well. This method, on the one hand, identifies the main affecting factors for estimating carbon emissions data, and on the other hand, it validates the method’s performance. It provides support for further policy development and change based on the outcome of this method.
Novel Ensemble Feature Selection Approach and Application in Repertoire Sequencing Data
Authors: He Tao , Baik Jason Min , Kato Chiemi , Yang Hai , Fan Zenghua , Cham Jason , Zhang Li
Published: April 2022

The T and B cell repertoire make up the adaptive immune system and is mainly generated through somatic V(D)J gene recombination. Thus, the VJ gene usage may be a potential prognostic or predictive biomarker. However, analysis of the adaptive immune system is challenging due to the heterogeneity of the clonotypes that make up the repertoire. To address the heterogeneity of the T and B cell repertoire, we proposed a novel ensemble feature selection approach and customized statistical learning algorithm focusing on the VJ gene usage. We applied the proposed approach to T cell receptor sequences from recovered COVID-19 patients and healthy donors, as well as a group of lung cancer patients who received immunotherapy. Our approach identified distinct VJ genes used in the COVID-19 recovered patients comparing to the healthy donors and the VJ genes associated with the clinical response in the lung cancer patients. Simulation studies show that the ensemble feature selection approach outperformed other state-of-the-art feature selection methods based on both efficiency and accuracy. It consistently yielded higher stability and sensitivity with lower false discovery rates. When integrated with different classification methods, the ensemble feature selection approach had the best prediction accuracy. In conclusion, the proposed novel approach and the integration procedure is an effective feature selection technique to aid in correctly classifying different subtypes to better understand the signatures in the adaptive immune response associated with disease or the treatment in order to improve treatment strategies.
Skin-Expressing lncRNAs in Inflammatory Responses
Authors: Shefler Alanna , Patrick Matthew T. , Wasikowski Rachael , Chen Jiahan , Sarkar Mrinal K. , Gudjonsson Johann E. , Tsoi Lam C.
Published: April 2022

Long non-coding RNAs (lncRNAs) have attracted attention for their potential roles in modulating keratinocyte differentiation and inflammatory response; however, for many identified skin-expressing lncRNAs, there is no comprehensive characterization regarding their biological roles. In addition, the reported expression profiles for lncRNAs can be ambiguous due to their low-expressing nature. The objective of this review is to utilize large scale genomic data to characterize the prominent skin-expressing lncRNAs, aiming to provide additional insights for their potential roles in the pathology of inflammatory skin of psoriasis and atopic dermatitis by integrating in vitro and in vivo data. We highlighted the different skin-expressing lncRNAs, including H19, which is significantly down-regulated in lesional skin of AD/psoriasis and upon cytokine stimulation in keratinocytes; it is also negatively correlated with CYP1A1 (r = -0.75, p = 8 × 10−73), a gene involved in drug metabolism and skin barrier homeostasis, in keratinocytes. In addition, SPRR2C, a potential regulator that modulates IL-22 stimulation, was upregulated in both atopic dermatitis and psoriasis lesional skin and was also downstream of the IL-17A and IL-17 + TNF signaling in keratinocytes. Using scRNAseq, we further revealed the cell type specificity of lncRNAs, including basal-expressing nature of H19 in the epidermis. Interestingly, instead of having cell type specific expression profile, we found few lncRNAs that are express across different cell types in skin, including MALAT1, NEAT1, and GAS5. While lncRNAs in general have lower expression, our results combining in vitro and in vivo experimental data demonstrate how some of these lncRNAs can play mediator roles in the cytokine-stimulated pathway.