bluuebunny/crossref_metadata_2025 huggingface dataset:
Opportunistic screening – The key to prevent glaucoma-related blindness
Authors: Bhagat Purvi Raj , Prajapati Kamini Mukesh Kumar , Chauhan Abhishek , Khobragade Sanath Rajesh , Mistry Arpita Vijay Kumar , Quraishi Rukhshanabanu Mohmmadsalim
Published: August 2024

Objectives:

Glaucoma is characterised by progressive optic neuropathy and irreversible blindness. Patients with glaucoma usually seek advice only in the advanced stages due to its asymptomatic nature. Hence, it is of utmost importance to diagnose the disease early and conduct screening and awareness programmes, especially for the population at higher risk.

Materials and Methods:

This was a cross-sectional community-based study carried out in various old age homes and senior citizen clubs in a metro city of Western India during World Glaucoma Week 2024. Glaucoma screening was performed, and awareness and counselling sessions were conducted for these senior citizens.

Results:

Out of 205 senior citizens screened, 64 were referred for a detailed glaucoma evaluation and 59 for cataract and retina assessment. Only 22 persons sought consultation, of which six were found to be glaucoma suspects, two had primary open-angle glaucoma, one had secondary open-angle glaucoma, and one was a post-trabeculectomy patient with absence of follow-up. All these citizens were managed and counselled appropriately with an emphasis on compliance and lifelong monitoring.

Conclusion:

Despite glaucoma being the second leading cause of irreversible blindness worldwide, awareness is lacking among the general population. The elderly age group, although at a higher risk, is usually unaware of the need for screening and follow-up and sometimes also does not have the necessary resources or assistance. Opportunistic screening and education about glaucoma are the key factors which can help in early detection of the disease and prevention of blindness.
The Frequency, Causes and Patterns of Asymptomatic Cardiac Arrhythmias in Patients on Maintenance Hemodialysis
Authors: Sakhare Yamita , Almeida Alan , Phalgune Deepak , Erande Aditi , Mehendale Sanjay Madhav
Published: August 2024

Background

The knowledge of the incidence of non-severe and clinically significant arrhythmias is limited in patients with chronic kidney disease (CKD). The present study was conducted to determine the incidence, pattern and identify the factors predisposing to cardiac arrhythmias in patients on maintenance hemodialysis.

Materials and Methods

Forty-five patients were included in this prospective observational study conducted between June 2020 and November 2021. Patients ≥ 18 years of age on maintenance hemodialysis (three times/week for at least three months), with no intercurrent illness, uremic symptoms, and not hospitalized in the previous 3 months were included. Demographic and clinical characteristics of the patients were noted. Arrhythmias were recorded by attaching the Holter machine to all study patients undergoing hemodialysis. We estimated the incidence, identified the pattern of cardiac arrhythmias, and explored the factors predisposing to cardiac arrhythmias.

Results

Premature atrial complexes (17.8%), premature ventricular complexes (31.1%), ventricular bigeminy (8.9%), trigeminy (8.9%), and ventricular couplets (22.2%) were observed. The patients with hyperparathyroidism, hyper/hypomagnesemia, and poor blood pressure control had significantly higher percentages of total and ventricular arrhythmias. The patients with hypomagnesemia, reduced left ventricular ejection fraction (<50%), poor blood pressure control, and receiving statins had significantly higher percentages of atrial arrhythmias. There was no statistically significant association between age, gender, diabetes mellitus, ischaemic heart disease, interdialytic weight gain, dialysis vintage, low hemoglobin, serum calcium levels, serum potassium levels, presence of left ventricular hypertrophy, pulmonary hypertension, and diastolic dysfunction with arrhythmias.

Conclusion

A high incidence of cardiac arrhythmias was noted among patients on hemodialysis.
Transradial versus transfemoral access for middle meningeal artery embolization: Choice of the access route considering delirium in the elderly
Authors: Yamamoto Manabu , Fujiwara Gaku , Takezawa Hidesato , Uzura Yasunori , Yokoya Shigeomi , Oka Hideki
Published: August 2024

Background:

Treatment of chronic subdural hematoma (CSDH) with middle meningeal artery embolization (MMAE) is becoming well established. Transradial artery access (TRA) is considered less invasive than transfemoral artery access (TFA) and is increasingly indicated in the field of endovascular therapy. Therefore, this study focused on postoperative delirium and compared access routes.

Methods:

This is a single-center and retrospective study. The strategy was to perform MMAE for CSDH with symptomatic recurrence at our hospital. Cases from July 2018 to September 2022, when MMAE was introduced in our hospital, were included in this study. Patients were divided into TRA and TFA groups and were compared descriptively for patient background, procedure duration, and incidence of postoperative delirium.

Results:

Twenty-five patients underwent MMAE, of whom 12 (48%) were treated with TRA. The overall median age was 82 years, with no clear differences between the TRA and TFA groups in the presence or absence of preexisting dementia or antithrombotic therapy. Delirium requiring medication tended to be lower in the TRA group: 2/12 (16.7%) in the TRA group versus 6/13 (46.2%) in the TFA group, and the mean procedure time for patients undergoing bilateral MMAE was 151 min (interquartile range [IQR]: 140–173 min) in the TRA group versus 174 min (IQR: 137–205 min) in the TFA group.

Conclusion:

TRA was associated with an overall shorter procedure time than TFA. MMAE through TRA tended to have a lower incidence of delirium. MMAE through TRA may be useful in recurrent CSDH with a high elderly population.
A dokumentumfilm mint a társadalom lelkiismerete
Authors: Argejó Éva
Published: August 2024

Sárközy Réka: Kinek a történelme? Emlékezet, politika, dokumentumfilm. Budapest, Országos Széchényi Könyvtár – Gondolat Kiadó, 2018. 285. p.
ANALYSIS OF THE INFLUENCE OF USING ACCESS POINTS IN STRENGTHENING THE NETWORK RECEIVING SIGNALS IN HOUSEHOLDS
Authors: Fauziah Hanifah Nur , Marpaung Jannus , Imansyah Fitri
Published: August 2024

From the results of the RSSI values that occur when researchers observe the walktest method and observe network quality in bandwidth when not using additional devices in the form of access points and after adding bandwidth in the form of access point devices, which are used to test and analyze the quality of an ICONNET telecommunications service system that used. The data retrieved shows that the RSSI results show a good category and index after the addition of an access point device, which helps to strengthen a multilevel home network. In this case several factors affect a network quality. One of them is the number of users at that time, the number of partitions in the terraced house affects the quality of the network, as well as the existence of several room dividers that cannot access the wifi. However, we can handle some of these factors by adding an access point to the multi-storey house. Distance and cable length, that is, cable distance and length greatly affect a network quality, the farther we are from the wifi router, the worse the quality of the network we get, but after adding an access point. In table 4.3 is the result of RSSI recapitulation on 3 different bandwidths. different, the average results for each bandwidth are shown in the form of data before with a bandwidth of 10 Mbps with data before -64 dBm and data after or data after the addition of an access point with an RSSI value of -47 dBm, so there is an increase in the bandwidth of 10 Mbps, namely -17 %,
Design Of Palm Shell Charcoal Media For Earthing Systems
Authors: Haris Muhamad Abdul , Rajagukguk Managam , Gani Usman A
Published: August 2024

The grounding system is an important part that must be considered to ensure the safety and reliability of the operation of the electric power system. The grounding system has an influence on the smoothness and safety of the electric power system, especially when there is a disturbance related to the ground. The aim of the grounding system is to limit the voltage between the equipment and the ground to a safe condition for all operations, both normal conditions and when a disturbance occurs. . The earthing resistance value in a building is <5Ω, while for earthing electronic equipment a grounding resistance value of <3Ω is required and for lightning arrester equipment or arresters it is <1.75Ω and some devices even require an earthing resistance value of <1Ω. The design for the construction of Palm Shell Charcoal Media for Earthing Systems was made by considering several problems, such as how to reduce the resistance value to comply with standards (PUIL). One of the efforts made is to design the addition of palm oil shell charcoal with variations in hole diameter and depth of planting the charcoal in the media. The results showed that factors such as the diameter of the charcoal planting medium and the depth of rod planting had a positive influence on the resistance value. The solution that can be applied to achieve optimal earthing resistance values is to increase the diameter of the charcoal media and deepen the rod planting
Study of Positioning Effect of Arrester Before and After FCO Next to Distribution Transformer Againts Lightning Surge Strikes
Authors: Maulasa Romi , Kurnianto Rudi , Gani Usman A.
Published: August 2024

There are 2 methods of placing the Arrester and Fuse Cut Out (FCO) as protection at  distribution substation, namely the placement of the Arrester before the Fuse Cut Out (FCO) and the placement of the Arrester after the Fuse Cut Out (FCO). Each method has a different impact in overcoming the coming lightning implosion voltage disturbance. The purpose of this study is to determine the effect of arrester placement before and after FCO on distribution transformers on lightning surge interference, and to find out how the performance of arresters and FCO when lightning surge interference occurs. In this study there are three calculations, namely the calculation of the arrester placement before the FCO, the calculation of the arrester placement after the FCO and the calculation of the maximum protection distance of the lightning arrester with the transformer. The results of this study are the placement of the Arrester before the FCO, the surge voltage that passes to the primary side of the transformer is 53,8567 kV/µs, this value is still below the transformer TID of 125 kV. Then in the Arrester placement after the FCO the surge voltage that passes to the primary side of the transformer is 58  kV/µs, this value is still below the TID of the transformer of 125 kV. The maximum distance of arrester placement to the transformer is 14,1 m. The conclusion of this research is that the arrester works optimally in the two placements as for FCO does not work well in the Arrester placement after FCO.
Unifying Geochemical Scenario for the Origin of a High Cellular Potassium to Sodium Ratio in Living Cells
Authors: Taran Olga
Published: August 2024

Potassium ion is the most common compound in all living organisms, with intercellular [K+]:[Na+] ratios greater than 1 across all domains of life. While most natural aquifers are rich in sodium, it is believed that localized potassium-rich environments were crucial for initiating prebiotic reaction networks leading to the origin of life. Several current hypotheses, based on modern geochemical observations, suggest that hydrothermal fields and their associated clays could have provided such environments. My work expands on current prebiotic theories regarding the origins of high potassium concentrations by providing a geochemical basis for the empirical observations proposed by other authors. Here, I show how abiotic enrichment in potassium can occur during the acidic alteration of a wide range of aluminum silicate rocks through the formation of alum salts (KAl(SO4)2•12H2O). I further propose how simple and well-known alum chemistry can lead to the accumulation of important biological molecules, such as phosphates, ammonia, and carboxylic acids. I provide a general thermodynamic model, proof-of-concept experiments, and a chemical rationale for the plausibility and importance of potassium-rich environments in the origin of life. This work suggests that potassium enrichment could have been one of the earliest steps in the origins of life, defining the reaction conditions where most prebiotic reactions took place. Since potassium is both the most common and simplest component in all living organisms on Earth, understanding the geochemical conditions that lead to potassium enrichment is valuable for comprehending the origins of life on Earth and the search for life elsewhere in the universe, including on our closest neighbor, Mars.
Hyperconjugation-Controlled Molecular Conformation Weakens Lithium-Ion Solvation and Stabilizes Lithium Metal Anode
Authors: Chen Yuelang , Liao Sheng-Lun , Gong Huaxin , Zhang Zewen , Huang Zhuojun , Kim Sang Cheol , Zhang Elizabeth , Lyu Hao , Yu Weilai , Lin Yangju , Sayavong Philaphon , Cui Yi , Qin Jian , Bao Zhenan
Published: August 2024

Tuning the solvation structure of lithium ions via electrolyte engineering has proven effective for lithium metal (Li) anode. Further advancement that bypasses the trial-and-error practice relies on the establishment of molecular design principles. Expanding the scope of our previous work on solvent fluorination, we report here an alternative design principle for non-fluorinated solvents, which potentially have reduced cost, environmental impact, and toxicity. By studying non-fluorinated ethers systematically, we found that the short-chain acetals favor the [gauche, gauche] molecular conformation due to hyperconjugation, which leads to weakened monodentate coordination with Li+. The dimethoxymethane electrolyte showed fast activation to >99% Coulombic efficiency (CE) and high ionic conductivity of 8.03 mS cm-1. The electrolyte performance was demonstrated in anode-free Cu||LFP pouch cells at current densities up to 4 mA cm-2 (70 to 100 cycles) and thin-Li||high-loading-LFP coin cells (200-300 cycles). Overall, we demonstrated and rationalized the improvement in Li metal cyclability by the acetal structure compared to ethylene glycol ethers. We expect further improvement in performance by tuning the acetal structure.
High-throughput enabled iridium-catalyzed C-H borylation platform for late-stage functionalization
Authors: Zakis Janis Mikelis , Lipina Rebeka Anna , Bell Sharon , Williams Simon R. , Mathis Maurus , Johansson Magnus J. , Wencel-Delord Joanna , Smejkal Tomas
Published: August 2024

In this work, we present an automated platform designed to facilitate the expedited use of late-stage C-H borylation in fast-moving discovery chemistry projects. Our microscale reaction optimization panel emphasizes the regiodivergent nature of different borylation protocols and provides a rapid assessment of all accessible positions with minimal starting material consumption. The approach taken provides a rapid and sustainable tool to evaluate reaction conditions targeting multiple C-H bonds. We illustrate the workflow by screening numerous fragment-like compounds, drugs and agrochemicals and demonstrate its practicality by successfully isolating 36 derivatives of bioactive compounds. Additionally, a systematic comparison of various catalytic methods using an informer library approach provides valuable insights regarding the desirable future direction of C-H borylation research.
Competitive Heavy-Atom Tunneling Reactions Controlled Through Electronic Effects
Authors: Roque José P. L. , Nunes Cláudio M. , Saito Fumito , Bernhardt Bastian , Fausto Rui , Schreiner Peter R.
Published: August 2024

Controlling QMT reactivity remains exceptionally challenging and largely unexplored, as it requires rationales distinct from those used for classical chemical reactivity. Herein, we investigated how QMT reactivity can be controlled using electronic substituent effects. Benzazirines, which have the exceptional feature to react via two competitive QMT pathways, were used as model compounds. Three novel derivatives with increasingly stronger electron-donating substituents at C4 [R = OH, N(CH3)2, and N(CH2)4] were generated in argon matrices at 3 K. Remarkably, different QMT selectivities were observed in all benzazirines. As the electron-donating strength of the substituent increases, the QMT ring-opening to nitrene starts to compete with the QMT ring-expansion to ketenimine, becoming the dominant process for the strongest electron-donating substituent [N(CH2)4]. A theoretical analysis of the substituent effects on the QMT reactivity of benzazirines was performed and compared with the experimental data for these and other C4 derivatives. Overall, the results compellingly demonstrate how subtle changes in electronic effects can be used to fine-tune QMT selectivity, and how the barrier widths, more than the barrier heights, are the determining factor.
Hijacking the MDM2 E3 Ligase with novel BRD4-Targeting PROTACs in Pancreatic Cancer Cells
Authors: Ficu Mihaela , Niculescu-Duvaz Dan , Aljarah Mohammed , Kershaw Christopher S. , Springer Caroline J.
Published: August 2024

The phenotypic effect induced by a Proteolysis-Targeting Chimera (PROTAC) can depend on several factors, including the E3 ligase recruited. For the discovery of a first-in-class PROTAC for a target of interest, the E3 ligases commonly hijacked remain the Von Hippel-Lindau (VHL) and Cereblon (CRBN) since potent and accessible ligands are readily available to recruit them. Mouse double minute 2 (MDM2) E3 ligase stands out because it regulates p53 levels to maintain cellular homeostasis. However, the synthesis of the most potent MDM2 ligands remains very complex. Here we report the discovery of novel MDM2-recruiting PROTACs incorporating rac-Nutlin-3 as a ligand with an easier synthetic tractability, further demonstrating its potential in this technology. The most promising degrader, PROTAC 3, showed preferential degradation of the BRD4 short isoform and c-Myc compared with MZ1, a validated VHL-based PROTAC.
Oligolysine Promotes and Inhibits DNA Condensate Formation
Authors: Ohno Hiroaki , Mabuchi Takuya , Ochi Yosuke , Taira Junichi , Sato Yusuke
Published: August 2024

The formation of biomolecular condensates via phase separation is crucial for cellular functions. Reconstituting these condensates with designed molecules allows for exploring their mechanisms and potential applications. Sequence-designed DNA nanostructures enable the investigation of the effects of structural design on condensate formation and construction of functional artificial condensates. Although DNA-based condensates have high designability, free nanostructures not assembled into condensates remain dispersed in solution. Herein, we report the effects of cationic oligolysines on DNA condensation. Our aim was to decrease the electrostatic repulsion between DNA nanostructures using oligolysines. Experimental results showed that DNA condensate formation was enhanced at an appropriate negative/positive charge (N/P) ratio. Surprisingly, oligolysines significantly inhibited condensate formation depending on the N/P ratio and residue number. Molecular dynamics simulations revealed that the deformation of the nanostructures induced by oligolysines likely caused this inhibition. We confirmed that the DNA condensates with oligolysines maintained sequence specificity in their interactions to demonstrate the applicability of the peptide/DNA hybrid condensates. These findings provide insights for further development of DNA/peptide hybrid condensates to enhance the functions of artificial condensates for use in artificial cells and molecular robots.
New Zealand Institute of Safety Management Health and Safety Reform Survey
Authors: Sissons Jeff
Published: August 2024

This paper provides a high-level summary of the Health and Safety Reform Survey conducted by the New Zealand Institute of Safety Management (NZISM) in April 2024. The survey gathered insights from over 1,321 health and safety professionals in New Zealand on the effectiveness of the health and safety system (including key aspects of the Health and Safety at Work Act 2015 and its supporting regulations along with areas requiring improvement). Key findings indicate a general level of comfort with the existing Act, a desire for greater regulation of particular risks (psychosocial risks, plant and machinery, sector-specific) and a desire for a better-resourced and more focused WorkSafe with an emphasis on inspector capability and guidance development.
The Influence of Depression on Different Age and Gender Groups in Bahawalpur
Authors: Khan Mehran , Muhammad Shahbaz  , Waris Tooba , Yaseen Shoaib , Afzal Iqra , Khadim Emaan , Usman Sawera , Shah Muhammad Ismail , Aslam Sulaiman , Iqbal Zafar
Published: August 2024

In Bahawalpur, a cross-sectional study assessed depression prevalence across age and gender groups, involving 442 participants from diverse socioeconomic backgrounds and settings. Utilizing the PHQ9 questionnaire, 84% were found to meet depression levels. The findings revealed a higher incidence in females (88%) than males (79%), with the greatest disparity among young adults, particularly young women, due to factors like academic pressure and financial stress. School children had the lowest depression rates (68%), possibly due to better immunity. Elderly individuals exhibited more severe depression, likely related to aging and domestic challenges. The study’s findings highlight a significant variation in depression severity across different demographic groups, with an overall higher incidence in women. The research underscores the necessity for targeted mental health resources and interventions tailored to the specific needs of each demographic group. It also points to the importance of addressing academic and socioeconomic stressors to mitigate depression, particularly among young women. While the study provides valuable insights, it relies on self-reported data, which may introduce bias. Therefore, future research should include clinical assessments to validate these findings and ensure a more accurate representation of depression within the community.
The Effectiveness of Albumin Combined with Diuretics in Treating Ascites in Cirrhosis
Authors: An Yajun
Published: August 2024

Cirrhosis often leads to various complications during its progression, with ascites being one of the most common. Among these cases, 5% to 10% are classified as refractory ascites. In recent years, clinical research on the treatment of cirrhotic ascites has yielded increasingly enriched results. In this paper, a large number of clinical data on the treatment of ascites using albumin combined with diuretics were collected, and it was found that there were more results in group control studies. It was believed that albumin combined with diuretic therapy could effectively improve symptoms, reduce the occurrence of adverse reactions, ensure the safety of patients, and have a good clinical application prospect. This paper reviews the efficacy of albumin combined with diuretics in the treatment of ascites in cirrhosis.
Analysis of the Role of D-Dimer, Interleukin-6, and Interleukin-18 in Differential Diagnosis of Pediatric Refractory Mycoplasma pneumoniae Pneumonia
Authors: Peng Yong , Li Aimin
Published: August 2024

Objective: To analyze the value of D-dimer (D-D), interleukin-6 (IL-6), and IL-18 in the differential diagnosis of children with refractory Mycoplasma pneumoniae pneumonia (RMPP). Methods: The medical records of 92 children with Mycoplasma pneumoniae pneumonia (MPP) treated in the hospital were selected for retrospective analysis from January 2023 to January 2024. After comprehensive examinations such as computed tomography examination of the chest, 48 children with general Mycoplasma pneumoniae pneumonia (GMPP) were put in the GMPP group and 44 children with RMPP were grouped in the RMPP group. The IL-6, IL-18, and D-D levels were compared between the two groups, and the receiver operating characteristic (ROC) curves were plotted to analyze their value for differential diagnosis of RMPP. Results: The levels of IL-6, IL-18, and D-D in the RMPP group were higher than those in the GMPP group (P < 0.05); the ROC curves showed that the specificity of the differential diagnosis of IL-6, IL-18, and D-D was higher, and their diagnostic value was significant. Conclusion: Determination of IL-6, IL-18, and D-D levels in children with MPP can further diagnose the children’s condition, which can help physicians formulate targeted treatment plans, and is of great significance to the improvement of the children’s condition, which is worthy of attention.
Recent Research Progress in Premature Ovarian Failure
Authors: Meng Yaping , Xia Xi , Jiang Wenjie , Hao Minghui , Fan Ziqi , Song Yihang
Published: August 2024

Premature ovarian failure refers to ovarian function failure in women before the age of 40 years due to follicular depletion or follicular dysfunction resulting in abnormal hormone levels. The etiology and pathogenesis of premature ovarian failure may be related to genetic, immunological, medical, environmental, infectious, psychological and enzyme deficiencies. The treatment involves Western medicine, Chinese medicine, and a combination of Chinese and Western medicine, and the treatment level includes hormone level, cellular level, surgery and psychological aspect. This paper would like to review the progress of the etiology, pathogenesis and treatment of premature ovarian failure in recent years.
The Role of ZNF207 in Liver Hepatocellular Carcinoma: Expression Analysis and Prognostic Implications
Authors: Peng Chengrui , Wu Linfei , Yang Xiaofang , Yao Hanyun , Xie Yan
Published: August 2024

Objective: To analyze the expression and clinical significance of the zinc finger protein ZNF207 gene in liver hepatocellular carcinoma (LIHC) based on The Cancer Genome Atlas (TCGA) database. Methods: The mRNA sequencing data of 371 cases of primary liver cancer, 50 cases of normal tissues, and 3 cases of recurrent liver cancer were downloaded from the TCGA database. The corresponding clinical information of the 371 cases of hepatocellular carcinoma was subsequently analyzed. The difference in ZNF207 expression between normal and tumor tissues was analyzed using the UALCAN online database. The impact of ZNF207 expression on survival prognosis was assessed using the Kaplan-Meier method in R software. The GO and KEGG pathways of ZNF207 were analyzed. The Cox proportional hazards model was used to evaluate the prognostic factors of patients with LIHC. RT-qPCR was employed to verify the expression of ZNF207 in LIHC cells. Results: ZNF207 was highly expressed in LIHC tissues and HepG2 cells, with a significant difference (P <  0.05). Multivariate Cox regression analysis revealed that patients with high ZNF207 expression had a significantly shorter overall survival time compared to those with low ZNF207 expression (HR = 1.466, 95% CI: 1.011–2.126, P < 0.05). GO enrichment analysis suggested that ZNF207 may influence the onset and progression of hepatocellular carcinoma by regulating mRNA splicing and mRNA transcription processing through the spliceosome. KEGG pathway enrichment analysis indicated that ZNF207 might affect the onset and progression of hepatocellular carcinoma through mitophagy, mRNA surveillance, homologous recombination, spliceosome, and nuclear-cytoplasmic transport. Conclusion: The expression of ZNF207 may be an independent predictor of the prognosis of patients with LIHC and could influence the development of hepatocellular carcinoma through various gene functions and pathways. It has the potential to serve as a novel molecular marker for predicting the prognosis of hepatocellular carcinoma.
Grande Estratégia: origens, abordagens e perspectiva brasileira
Authors: Dhenin Miguel
Published: August 2024

Esse artigo tem como objetivo apresentar o conceito de “grande estratégia” para os leitores lusófonos. A partir de um levantamento bibliográfico, verificou-se que poucas fontes em português abordam de forma abrangente a complexidade do conceito. Queremos, num primeiro momento, evidenciar nesse trabalho a diversidade das definições da “grande estratégia”, principalmente a partir de fontes anglo-saxônicas. Em seguida, faremos um levantamento dos significados atribuídos à grande estratégia, entre o momento da formulação do conceito (início do século XX) até os dias de hoje. Finalmente, evidenciaremos as abordagens brasileiras do conceito, principalmente na maneira de avaliar como os Estados modernos procuraram definir seus objetivos estratégicos.
Mann, Michael,2023.On Wars.
Authors: Rei Coronato Daniel
Published: August 2024

Mann, Michael.On Wars,2023.New Haven: Yale University Press. ISBN 978-0-300-26681-8.
IMPLEMENTASI DESIGN THINKING UNTUK PERANCANGAN UI/UX APLIKASI ONE COLLECTING AGENT (OCA)
Authors: Pujastuti Eli , Nurmasani Atik , Widayani Wiwi , Farida Lilis Dwi , Widjiati Nur , Kusumaningrum Andi Sutra
Published: August 2024

Aplikasi One Collecting Agent (OCA) adalah sebuah aplikasi yang dibangun untuk mempermudah pengumpulan data pengelolaan Pajak Penghasilan (PPh) kegiatan Perguruan Tinggi untuk PPh 21, PPh 23, dan PPh 4 Ayat 2 khususnya di Universitas ABC. Dimana, pengelolaan PPh tersebut masih dilakukan dengan bantuan google spreadsheet yang menimbulkan adanya permasalahan seperti, tampilan lembar kerja di dalam spreadsheet berbentuk tabel menyamping membuat pengguna mengalami kesulitan dalam pengisian data yang mengakibatkan ketidakefektifan pengoperasian dan kinerja pengguna. Oleh karena itu, diperlukan adanya sebuah perancangan UI/UX dan frontend berbasis website untuk memberikan tampilan lembar kerja yang lebih nyaman dan optimal. Tujuan dari penelitian ini adalah melakukan perancangan UI/UX dan frontend aplikasi One Collecting Agent (OCA) dengan menerapkan metode Design Thinking agar dapat memenuhi tampilan desain antar muka yang dibutuhkan dan diinginkan pengguna.  Metode Design Thinking adalah metode yang berpusat pada manusia untuk memecahkan masalah yang muncul dari pengguna. Metode ini memiliki 5 tahap, yaitu empathize, define, ideate, prototype, dan test. Tahap empathize merupakan tahap mencari permasalahan dan kebutuhan pengguna. Tahap define dan ideate merupakan tahap menentukan masalah dan merancang ide solusi.  Tahap prototype adalah tahap mengimplementasikan ide solusi ke dalam tampilan desain. Tahap test dilakukan dengan pengujian prototype kepada 30 responden menggunakan metode System Usability Scale (SUS) yang diperoleh hasil 75 dengan kategori Excellent, Acceptable, dan grade scale C.  Hasil penelitian ini adalah perancangan UI/UX dan frontend aplikasi One Collecting Agent (OCA) menggunakan metode Design Thinking yang dapat memenuhi tampilan desain antar muka yang dibutuhkan dan diinginkan pengguna.
Perancangan Aplikasi Edukasi Pencegahan Kebakaran Rumah Berbasis Android Dengan Metode Linear Congruential Generator
Authors: Al Ghifari Mohammad Fariz
Published: August 2024

Perancangan aplikasi edukasi pencegahan kebakaran rumah berbasis Android dengan metode Linear Congruential Generator (LCG) untuk pengacakan soal pada menu kuis. Kebakaran merupakan bencana yang sering terjadi dan memiliki potensi bahaya besar bagi masyarakat. Aplikasi ini bertujuan untuk meningkatkan kesadaran masyarakat tentang bahaya kebakaran dan cara mencegahnya melalui edukasi yang mudah diakses. Aplikasi ini menggunakan metode LCG untuk pengacakan urutan soal dalam menu kuis, sehingga setiap pengguna mendapatkan urutan soal yang berbeda dalam setiap sesi. Materi edukasi meliputi penjelasan tentang kebakaran, cara mitigasi dan pencegahan kebakaran rumah, serta tata cara menanggulangi kebakaran jika terjadi. Hasil penelitian ini adalah aplikasi edukasi yang menarik dan informatif, memberikan kemudahan bagi pengguna untuk memahami pencegahan kebakaran dan menguji pengetahuannya melalui menu kuis yang teracak. Aplikasi ini diharapkan dapat membantu meningkatkan kesadaran masyarakat tentang pentingnya pencegahan kebakaran dan mengurangi risiko terjadinya kebakaran rumah.
Use and underlying principles of the EFSA Pesticide Residue Intake Model (PRIMo), revision 4
Authors:   European Food Safety Authority (EFSA), Dujardin Bruno , Horváth Zsuzsanna , Reich Hermine , Costanzo Violetta
Published: August 2024

Abstract
The EFSA Pesticide Residue Intake Model (PRIMo) has, since its first version in 2007, become the standard tool used at the EU level to estimate the short‐ and long‐term dietary exposure to pesticide residues. It is a deterministic model and is primarily used as a prospective screening tool for dietary risk assessment in the framework of Regulation (EC) No 396/2005 and Regulation (EU) No 1107/2009. Unlike its previous Excel‐based versions, PRIMo 4 has been converted to an online web‐application. The aim of the present report is to describe the features and functionalities of the latest version of PRIMo and provide guidance to its future users. One of the main novelties is that the model uses individual consumption data from the Comprehensive Food Consumption Database of EFSA, where the foods reported as consumed were disaggregated to their ingredients and converted to their raw primary commodity (RPC) equivalents by means of the EFSA RPC model. This innovation allows to have more detailed exposure assessment results, including results for minor products and processed foods.
STATE MANAGEMENT OF THE RUSSIAN ECONOMY IN THE TWENTIETH CENTURY: HISTORICAL AND LEGAL ASPECTS
Authors: KOBZAR-FROLOVA M.
Published: August 2024

The article is devoted to the historical and legal aspects of state management of the Russian econ-omy of the Soviet period (1921-1991): Despite the long-standing historical events under considera-tion, the issues raised in the article are very relevant and arouse interest not only among economists, but also among administrative scientists. The period under consideration involves the presentation of a large volume of material, which cannot be allowed in the article. In this regard, the work is present-ed in abstracts, and the information in the article is structured by decade. In conclusion, the author's conclusions are presented
OPTIMIZATION OF MEASURES AIMED AT ANTI-TERRORIST SECURITY OF OBJECTS WITH MASSIVE PEOPLE OCCUPATION
Authors: Kobets P
Published: August 2024

Today, the efforts of international terrorists are aimed not only at intimidating society, but also at de-stroying as many ordinary citizens as possible who turned out to be accidental participants in the tragic events taking place. In this regard, the issues of developing measures related to ensuring anti-terrorist security in relation to more unprotected and vulnerable objects with large numbers of people exposed to terrorist threats are of particular relevance. Attacks on them occur without thorough preparation, thereby providing a significant advantage to terrorists. Such terrorist attacks are difficult to predict and prevent. In order to counter modern threats of international terrorism in relation to more unprotected and vulnerable objects, a set of special measures aimed at minimizing potential terrorist threats is important. In the process of research, the author notes that in a comprehensive assessment of the analyzed terrorist threats and risks, it is necessary to determine the factors con-tributing to the emergence of such risks, and also strive to develop actions to prevent terrorist attacks or minimize their consequences. Determining specific measures aimed at ensuring anti-terrorist se-curity of the objects in question could be facilitated by their categorization and certification. In con-clusion, the author draws conclusions that in order to protect facilities most exposed to the risk of ter-rorist threats, a special role should be played by the improvement of proactive countermeasures, which must be grouped around the main areas: identifying these threats; development of public-private cooperation in the area under consideration; carrying out preventive work with society; an integrated approach based on high-quality security, effective access control and competent leadership, etc. In particular, the emphasis is placed on the fact that anti-terrorist security requires constant new original solutions to the problem associated with the protection of vulnerable objects and targets. Therefore, when assessing the anti-terrorist security of each vulnerable object and target, individual approaches are required. At the same time, the author especially notes the importance of continuing research into the characteristics of modern international terrorism in order to prepare a comprehensive, scientifically based approach to creating an anti-terrorism system for the protection of potential vulnerable objects and targets
ABOUT SOME MODERN TRENDSDRUG TRAFFICKING IN TRANSPORT AND TRANSPORT INFRASTRUCTURE FACILITIES
Authors: Shnayder Natal'ya
Published: August 2024

The strategy of the state anti-drug policy of the Russian Federation for the period until 2030 (herein-after referred to as the Strategy) provides for the implementation of a multi-factor model carried out by subjects of anti-drug activities in order to reduce the availability of drugs for illicit consumption, re-duce illicit drug trafficking, and create a conscious negative attitude towards illicit consumption in so-ciety drugs and participation in their illicit trafficking.
Considering that drugs are moved and sold through the use of transport, postal items, transport and logistics infrastructure, internal affairs bodies in transport (hereinafter referred to as OVDT) should be given one of the leading roles in the practical implementation of measures to prevent drug trafficking.
The article contains the results of a study of statistical indicators of the Federal State Institution «GIAC of the Ministry of Internal Affairs of Russia» for the period 2019-2023, empirical and theoreti-cal material, the analysis of which made it possible to identify current trends in drug crime in transport and transport infrastructure facilities.
The conclusions reached by the author demonstrate the current state and trends of crime in the field of drug trafficking (hereinafter – NON) in transport and transport infrastructure facilities; substantiate the need for organizational and managerial decisions to improve the quality of inspection activities; state the expediency of considering the issue of improving legislation regulating the implementation of freight forwarding activities, and also, strengthening operational and investigative cooperation.
ON SOME ISSUES OF DEFINING THE CONCEPT OF «SANCTION» IN MODERN LEGAL SCIENCE
Authors: Dzhindzholiya Raul'
Published: August 2024

The article examines the retrospective and modern aspects of the definition of sanctions in interna-tional law, characterizes various types of sanctions, including international political and economic sanctions. The author's interpretation of the definition of international sanctions is proposed, taking into account the modern realities of world politics, describes the mechanism for analyzing interna-tional sanctions, using the example of sanctions that have been in force and are in force against Iraq, Iran and Cuba, their consequences and countermeasures. The article also examines the issues of expediency and fairness of unilateral sanctions, analyzes countermeasures (retaliatory measures) that a state can apply in response to international legal violations of another State.
Nursing Care According to Gordon's Model of Functional Health Patterns in a Patient Diagnosed with Bipolar Disorder and Fronto-temporal Dementia: A Case Report
Authors: Korkmaz Azime , TAŞDEMİR Gülay , BOZKURT Pınar Sevda
Published: August 2024

Amaç: Bu çalışmanın amacı, bipolar bozukluk ve fronto-temporal demans tanısına sahip bir hastada Gordon’un Fonksiyonel Sağlık Örüntüleri Modeli’ne dayalı hemşirelik bakımının etkilerini değerlendirmektir. Yöntem: Psikiyatri kliniğinde
tedavi gören bir hastanın verileri, Gordon’un Fonksiyonel Sağlık Örüntüleri Modeli kullanılarak toplanmıştır. Değerlendirme sonucunda belirlenen hemşirelik tanıları sağlığı sürdürmede yetersizlik, düşme riski, beden gereksiniminden
az beslenme, üriner inkontinans, eğlence aktivitesinde eksiklik, uyku örüntüsünde rahatsızlık, bellekte bozulma, aile içi süreçlerin devamlılığında bozulma ve suisid riski şeklindedir. Bulgular: Hemşirelik tanıları doğrultusunda
yapılan bakım, hastanın sağlık durumu ve yaşam kalitesi üzerinde olumlu etkiler göstermiştir. Sonuç: Gordon’un Fonksiyonel Sağlık Örüntüleri Modeli, kompleks durumları olan bireylerin hemşirelik bakımında etkili bir araç olarak
kullanılabileceği düşünülmüştür. Bu modelin kullanımı, bipolar bozukluk ve fronto-temporal demans tanısına sahip hastalarda daha kapsamlı ve bireye özel bakım planları geliştirilmesine yardımcı olabilir. Bu tür model temelli çalışmaların
yaygınlaştırılması önerilmektedir.
Performance evaluation of Near-Threshold Ultradeep Submicron Digital CMOS Circuits using Approximate Mathematical Drain Current Model
Authors: Kalra Shruti , Singh Karan
Published: August 2024

This paper examines CMOS inverter performance near threshold voltage using a tailored drain current model for submicron nodes up to 22nm. Validated via HSPICE simulations, the model incorporates factors like inverse narrow width effect, Miller capacitance, and layout dependencies. Demonstrating continuity and precision across a wide operational spectrum, results indicate deviations within 1-5%, affirming the model’s robustness.These findings underscore its utility for designers grappling with the intricacies of near-threshold voltage operation, offering a reliable framework to optimize CMOS inverter performance in ultra-deep submicron technologies.
Design of a Double Gate Tunneling Field Effect Transistor (DG-TFET) and Performance Analysis
Authors: Pavan Kumar Chinnala , Sivani K
Published: August 2024

The Double-Gate Tunnel Field-Effect Transistor (DG-TFET) has emerged as a promising contender in modern semiconductor technology, offering distinct advantages over conventional devices. This paper delves into the pivotal performance metrics of DG-TFETs: sub-threshold slope (SS), ON current (Ion), and work function modulation, which collectively contribute to heightened device functionality.Sub-threshold slope, a critical parameter for energy efficiency, sees significant enhancement in DG-TFETs owing to their inherent ability to precisely control the tunneling barrier. The incorporation of dual gates enables precise tuning of the tunneling process, resulting in steeper SS values compared to traditional devices. This attribute is crucial in minimizing leakage currents during device operation, thus ensuring superior power efficiency.Additionally, the ON current of DG-TFETs serves as a vital indicator of their switching prowess. The dual-gate architecture facilitates enhanced electrostatic control, leading to heightened ON current levels. This aspect is pivotal for achieving faster switching speeds, thereby ensuring seamless integration into high-performance circuits.Work function modulation stands out as a key feature in DG-TFETs, facilitating tailored band alignments and improved device characteristics. Through independent adjustment of the work functions of the source and drain regions, the device can be finely tuned to optimize tunneling efficiency and overall performance. This capability holds significant implications for circuit design and customization, augmenting the versatility of DG-TFETs.In essence, the Double-Gate Tunnel Field-Effect Transistor presents a compelling avenue for advancing semiconductor technology. By addressing sub-threshold slope, enhancing ON current, and modulating work functions, DG-TFETs offer a promising solution for achieving higher energy efficiency, faster switching speeds, and versatile device optimization. As the semiconductor landscape continues to evolve, DG-TFETs hold substantial potential for shaping the future of integrated circuits and electronic devices.This study involves the design and evaluation of three distinct transistor configurations: a conventional Metal-Oxide-Semiconductor Field-Effect Transistor (MOSFET), a Single Gate Tunnel Field-Effect Transistor (TFET), and a Double Gate TFET. The mentioned devices are simulated using Silvaco TCAD (Technology Computer Aided Design) tools. The evaluation primarily focuses on key performance metrics, specifically sub-threshold slope and ON current, to comprehensively assess the effectiveness of the Double Gate TFET.
Characterization of Switching Properties in ReRAM Devices by the Capacitance of the MIM Structure
Authors: Costa Fernando Jose , Zeinati Aseel , Trevisoli Renan , Misra Durga , Doria Rodrigo T.
Published: August 2024

In this article, an analysis of the switching mechanism in Resistive Random-Access-Memory devices in relation to the capacitance variation of the Metal-Insulator-Metal structure is performed through experimental capacitance measurements. A variation in the capacitance was observed when a set of pulses with different widths and amplitudes was applied to the devices in the Multi-Level-Cell regime. The presence of multiple resistive states can be observed also with the changes in the dielectric constant of the material’s insulating layer. The migration of the defects inside dielectric is responsible for the devices exhibiting multiple capacitive reactance states, demonstrating the quantization of the conductance, required for the application in in-memory computing systems.
Effect of multiple conductions on basic parameters in linear and saturation regions for a MIS-HEMT from 450 K down to 200 K
Authors: Perina Welder Fernandes , Martino Joao Antonio , Simoen Eddy , Peralagu Uthayasankaran , Collaert Nadine , Der Agopian Paula Ghedini
Published: August 2024

In this work, the effect of multiple conductions on the basic parameters in linear and saturation regions of a GaN based Metal-Insulator-Semiconductor High Electron Mobility Transistor (MIS-HEMT), when operating in a temperature range from 450 K down to 200 K, is evaluated experimentally. The threshold voltage behavior suggests that the HEMT conduction is dominating the device for low temperatures, while the MOS conduction is the dominant one for high temperatures. It is also shown that the presence of a high gate leakage current is degrading the switching efficiency and the ION/IOFF ratio of the device. The device presents a minimum Drain Induced Barrier Lowering (DIBL) of 27 mV/V (at 300 K) and the maximum of 62 mV/V (at 450 K).
Temperature Measurement of a Nanowire SOI Transistor Using a Parallel Gated SOI PIN Diode
Authors: Rodrigues Gare Carnielli Felipe , Pavanello Marcelo Antonio
Published: August 2024

This paper outlines a technique for measuring the temperature rise in a nanowire SOI MOSFET, caused by the self-heating effect, utilizing a parallel gated PIN diode. The analysis is conducted through electrothermal 3D TCAD simulations across an environment temperature range of 300K to 600K. Additionally, the impact of the separation distance between the nanowire MOSFET and the PIN diode is thoroughly examined.