bluuebunny/crossref_metadata_2025 huggingface dataset:
EXPERIMENTAL EVALUATION OF MN(II)-TRANS-1,2-DIAMINOCYCLEHEXANE-N,N,N',N'TETRAACETATE AS PARAMAGNETIC CONTRAST AGENT FOR ENHANCEMENT OF CEREBRAL MENINGEOMAS IN DOGS
Authors: Ussov V. Yu. , Bezlepkin A. I. , Borodin O. Yu. , Belyanin M. L. , Filimonov V. D.
Published: June 2020

Aim of research. We have evaluated the abilities of new original paramagnetic contrast agent Mn-DCTA (0,5 mol solution of Manganese(II) complex with trans-1,2-diaminocyclohexane-N,N,N',N'-tetraacetate, registered trade mark Cyclomang) for contrast-enhanced imaging of brain meningeomas in dogs.Material and methods. Twelve animals were included, all with brain tumors reveald during out-patient veterinary examinations. In ten of twelve the diagnosis was verified later by pathomorphologic study. The cerebral MRI has been carred out as set of axial, sagittal and coronal slices as thin as three to five mm, covering all the volume of brain.The scanning parameters in T1-weighted spin-ech mode were as follows: TR = 400–500 ms, TE = 15–20 ms, the dose of injected paramagnetic was standardised as 1 mmol per 10 kg of body weight. For quantitative analysis the index of enhancement was calculated.Results. In all cases the sure enhancement with clear visualization of cerebral tumor was obtained due to highly intensive uptake of Mn-DCTA to the tumor tissue. When evaluated quantitatively the uptake of Mn-DCTA to the tumor gave the index of enhancement in T1-weighted spin-echo mode as high as IE = 1,72 ± 0,18 for the central parts of tumor and IE = 2,08 ± 0,23 for the peripheral ones, where as in control animals it was far below these values. Intravenous injection of Mn-DCTA to dogs with cerebral tumors did not induce any detectable pathologic or even physiologic effects.Conclusion. Henceforth we conclude the Mn-DCTA provides highly available methodologically simple imaging of cerebral meningeomas and can be thought out as promising paramagnetic agent for clinical magnetic resonance imaging in humans.
OXIDATIVE MODIFICATION OF PROTEINS AND GLUTATHIONE SYSTEM IN ADIPOCYTES UNDER DIABETES
Authors: Shakhristova Ye. V. , Stepovaya Ye. A. , Ivanov V. V. , Nosareva O. L. , Ryazantseva N. V. , Novitsky V. V.
Published: June 2020

Currently, diabetes ranks third in relation to medical and social significance after cardiovascular diseases and cancer and is the leading cause of blindness; it greatly increases the risk of myocardial infarction, coronary heart disease, nephropathy and hypertension in patients with this disorder; therefore clinical and experimental studies aimed at investigation of diabetes emergence and development mechanisms are urgent.The aim of the study was to investigate the status of oxidative modification of proteins and glutathionedependent antioxidant defense system in adipocytes of rats with alloxan diabetes under conditions of oxidative stress.Material and methods. Development of type 1 diabetes was induced in rats by alloxan administration (90 mg/kg of body mass). Adipocytes were obtained from epididymal adipose tissue of rats. The level of carbonyl derivatives of proteins, oxidized tryptophan, bityrosine, general, reduced, oxygenated and protein-bound glutathione, as well as glutathione peroxidase activity in adipocytes of rats was determined.Results. In adipocytes of rats with alloxan diabetes, concentration of carbonyl derivatives of proteins, bityrosine and oxidized tryptophan increased on the background of redox-potential of glutathione system and glutathione peroxidase activity decrease.Conclusion. The obtained data indicate the activation of free-radical oxidation of proteins and reduction of antioxidant defense under conditions of oxidative stress in the adipose tissue of rats with alloxan diabetes; this process plays an important role in pathogenesis of diabetes and its complications development.
ENTROPY METHODS IN ANALYSIS OF BIOLOGICAL SYSTEMS
Authors: Berestneva O. G. , Pekker Ya. S. , Murzina S. S.
Published: June 2020

The adaptation of people to new production environment are often influenced by very unusual, excessive and harsh environmental factors, genetically inadequate to its nature. Human adaptation to the new production conditions can be summarized as a set of social and biological properties and characteristics needed to sustain the existence of the human body in a particular ecological environment.

It is necessary under the new conditions to achieve harmony of human interaction with the physical environment of their lives, adequate human nature. In addressing this fundamental problem of the primary role belongs to biomedical science, which should not so much to predict the appearance of the disease, how much help to preserve and improve the health of population. At the same time beco­ming increasingly clear that solving this problem adaptation theory plays a crucial role.

Adaptive features appear only in real life. It is in particular natural or artificial habitat capabilities of the body, when the survival and life require maximum mobilization and stress its potential adaptive capacity. Consequently, the property adaptation of living systems is, in fact, a measure of individual health.

An approach based on entropy methods for modeling complex systems, seems to be the most promising for integrated assessment of biological systems.
USING BIOFEEDBACK FOR REHABILITATION OF PATIENTS WITH PARKINSON'S DESEASE
Authors: Grebysheva T. S. , Brazovskaya N. G. , Zhukova I. A. , Nikitina M. A. , Izhboldina O. P. , Zhukova N. G. , Alifirova V. M. , Pekker Ya. S.
Published: June 2020

The effectiveness of a self regulation technique based on the biological feedback (BFB) has been studied during treatment in patients with Parkinson's desease. The specific recommendations for patients with Par­kinson's desease have been determined taking into account an appearance of the distinctive symptoms. The treatment method based on the BFB has been realized. The controllable physiological signals both electrocardiography and electromyography have been used in this method. The rehabilitation psycho-physiological complex “Reakor” has been used for the treatment and diagnostic procedures as well. The statistical analysis of the effectiveness of the self regulation method was performed. It has been shown the combination of medication and biofeedback training aids in the normalization of personal emotional parameters.
THE PROCESSING AND TRANSMISSION FOR MEDICAL STATISTICS BASED ON THE INTERNATIONAL STANDARD ISO 13606
Authors: Kopanitsa G. D.
Published: June 2020

A possibility to unite different healthcare providers in one network was investigated and proved. We developed solution based on ISO 13606 archetype model and service oriented architecture to enable an exchange of semantically meaningful medical data within a network of healthcare providers. Application of a data model of the ISO 13606 standard for data modeling and XML data transformation allowed organizing data exchange in the regional healthcare network.
VISUALIZATION OF DATA AND RESULTS AS А METHODOLOGICAL BASIS OF APPLIED STATISTICS TEACHING
Authors: Nuriakhmetov R. R.
Published: June 2020

Traditional methods of teaching in medical high school of informatics as computer sciences and statistics as a section of high mathematics contradict to requirements of modern applied medicine and a medical science. A research objective is revealing of the reasons of the given discrepancy and its elimination ways. Similar discrepancy was revealed earlier by foreign researchers studying efficiency of the statistic school programs. The revealed laws appeared to be extended to a technique of teaching of statistics in a high medical school. Pursuing this aim the tests of educational achievements developed by the author were applied on the students of medical and biologic department of the Siberian State Medical Universirty that trained on specialities of “biophysics" and “biochemistry". The fundamental problem of statistical education is that symbols used by these science concern to the objects, which students still have to design. As a substantiation of this conclusion serves the ontosemiotical approach to working out of the maintenance of a course. In the article there are considered the approaches to the permission of the given contradiction, based on the experience of teaching of statistics in foreign schools and on the wor­kings out of the author. In particular the conclusion about necessity of revision the tradition of using professional statistical packages and introduction of a special educational software. To working out the maintenance of a learning course it is offered to more widely apply the historical approach which concrete definition is represented by a principle of a guided reinvention.
OPTIONS FOR REGISTRATION OF THE LUNGS MAXIMUM MECHANICAL ACTIVITY, WHICH IS AIMED AT OVERCOMING INTERNAL-LUNG RESISTANCE
Authors: Tetenev K. F. , Bodrova T. N. , Ageeva T. S. , Karzilov A. I. , Tetenev F. F.
Published: June 2020

The paper presents the results of assessing general and elastic lung hysteresis in 21 healthy volunteers and 28 patients with community-acquired pneumonia. Negative elastic hysteresis was detected in 14 healthy volunteers and 18 patients with community-acquired pneumonia. For the first time ever, it was demonstrated that, under the conditions of an interrupted air flow, 4 healthy volunteers and 2 patients with community-acquired pneumonia were characterized with the inversion of not only elastic but also general lung hysteresis. In case of pneumonia, despite the increase in tissue friction resulting from the generalized escalation of the alveolar-capillary permeability, the inversion of both elastic and general lung hysteresis takes place as often as in healthy people. It can be explained with the intensification of the mechanical activity of the lungs as a compensatory reaction in the mechanical system of the external respiration organs in case of pneumonia.
STRUCTURAL AND FUNCTIONAL HETEROGENEITY OF ASTROCYTES IN THE BRAIN: ROLE IN NEURODEGENERATION AND NEUROINFLAMMATION
Authors: Morgun A. V. , Malinovskaya N. A. , Komleva Yu. K , Lopatina O. L. , Kuvacheva N. V. , Panina Yu. A. , Taranushenko T. Ye. , Solonchuk Yu. R. , Salmina A. B.
Published: June 2020

The review covers the current concepts on structural and functional heterogeneity of brain astrocytes that serve for numerous (patho)physiological processes in the central nervous system. Astrocytes from various subpopulations demonstrate different sensitivity to the action of pathogenic factors, varied behaviors in reactive processes and within the local immune response. Key functions of astrocytes like neurogenesis, neuron-astroglia metabolic coupling, glial control of local blood flow greatly depend on the origin and characteristics of astroglial cells. Changes at the initial stages of neurodegeneration or in neurodevelopmental disorders are associated with significant alterations in astroglial structural and functional properties, thus suggesting new approaches to therapeutic strategies implementing astroglia-expressing molecules and targets for effective
MODERN VIEWS ON BILATERAL BREAST CANCER
Authors: Fesik Ye. A. , Krakhmal N. V. , Zavyalova M. V. , Perelmuter V. M. , Slonimskaya Ye. M. , Vtorushin S. V.
Published: June 2020

Presented modern literature data on the features of the pathogenesis, course, clinical and morphological expression and tumor characteristics, parameters and nodal metastasis of hematogenous bilateral breast cancer. Highlight the results of domestic and foreign studies in recent years to determine the prognostic factors and recurrence of synchronous and metachronous bilateral breast cancer. It was revealed that the frequency of bilateral breast tumor lesions varies widely, ranging from 0.1 to 20%, with metachronous tumors recorded significantly higher (69.6% ) than the synchronous (22.7%). The probability of occurrence of metachronous breast cancer is higher in women with a family history, as well as if they have a gene mutation BRCA-1. Found that the most common histological type of breast tumor with bilateral lesions is invasive ductal. However, the incidence of invasive lobular cancer and non-invasive lobular cancer is slightly higher among synchronous bilateral cancer compared with unilateral disease. Studies have shown that in a double-sided synchronous breast cancer tumor, as a rule, has a lower degree of differentiation, and the higher the expression level of estrogen receptors and progesterone receptors. Relevance of the issue because the identification of patterns in the study of lymphatic and hematogenous features bilateral metastasis of mammary tumors provides a basis for speculation about the differences in the progression of neoplastic disease in these groups and is a cause for further detailed research in this area to identify and evaluate the prognosis and also the choice of tactics of such patients.
ENDOTHELIAL DYSFUNCTION IN MEN - A CLINICAL VIEW
Authors: Khripun I. A. , Gtisova Z. R. , Ibishev H. S. , Sultanmuradova A. S. , Vorobiev S. V. , Kogan M. I.
Published: June 2020

Endothelial dysfunction is an early marker for the development and progression of cardiovascular diseases. Scientific studies in recent years have shown the necessity to study the endothelial function in different groups of patients in clinical practice. This article is focused on the possibilities and perspectives for clinical use of laboratory and instrumental methods for the study of endothelial function. One of the factors causing the development of vascular disease in men is testosterone deficiency. The review highlights the most important mechanisms of action of sex hormones on the vascular endothelium and its function in men. The data about the effects of hormone replacement therapy with testosterone on endothelial function in patients with late onset hypogonadism were critically analyzed.
DETERMINATION OF INDIVIDUAL FEATURES OF BALANCE RETAINING IN PATIENTS WITH CEREBRAL PALSY USING STABILOMETRY TESTING
Authors: Davydov O. D. , Montile A. I. , Marchuk Yu. V. , Montile A. A.
Published: June 2020

The practical aim of the research is to develop a methodology for assessing the functional state of the musculoskeletal system in the case of complex human pathologies and associated injuries with the objective distinction of interdependent anatomical and functional disorders in the osteoarticular system, nervous and muscular subsystems, identification pathology severity in the separate subsystems and the degree of influence for each of them on the movement organization as a whole. In patients with cerebral palsy the neurological movement disturbance is a priority component, differentiation of which may by difficult due to lack of tools to evaluate objectively and display the features of functioning nervous system in normal and pathological conditions. The authors propose a set of interval indicators of stabilometric study and method to use it providing the more qualitative consideration individual characteristics and the formation of clinically interpretable representation of a visual results image as compared with the standard vector and frequency indicators.
APPLICATION OF A BIODEGRADABLE MATERIAL FOR BONE REPLACEMENT IN TRAUMATOLOGY
Authors: Druzhinina T. V. , Trofimov K. V. , Naydanov V. F. , Rostovzev A. V. , Burkov D. V. , Zhulyabin A. V. , Isupov A. A. , Verevin A. V.
Published: June 2020

20 men (medium age (31.5 ± 13.5) years) were studied. All patients underwent arthroscopic auditing plastic anterior cruciate ligament of the knee. Osteoregeneration dynamics were determined by biochemical testing of blood serum and X-ray computed tomography (CT) of the fracture in 1–4 months after surgery. As a result, an estimation of the bone tissue reparative regeneration according to CT data in 10 patients with a defect of the patella, treated with the material is provided. The obtained results of the clinical study indicate the reparative effect of the biodegradable material for bone replacing on bone regeneration
PECULIARITIES OF THE FUNCTIONAL ACTIVITY OF BLOOD EOSINOPHIL GRANULOCYTES IN PULMONARY TUBERCULOSIS
Authors: Kolobovnikova Yu. V. , Urazova O. I. , Novitskiy V. V.
Published: June 2020

Eosinophils are polyfunctional leukocytes detected in excess in blood and in the focus of granulomatous inflammation in pulmonary TB.

The research objective was to evaluate the adhesive properties as well as cytokine-secretory and antibacterial activity of blood eosinophils in pulmonary TB.

The research has been conducted on eosinophils isolated from peripheral blood of 43 patients with freshly identified progressive destructive TB with and without eosinophilia. Using flow cytometry and ELISA, expression of CD9 and CD18 adhesion molecules on blood eosinophils has been studied along with the phagocyte and cytokine-secretory functions and activity of eosinophil granulocyte peroxidase.

As a result of the research it has been established that in TB patients with eosinophilia the number of CD18-expressing eosinophils rises, whereas the amount of CD9+ remains within norm. Activation of the phagocyte function of blood eosinophil granulocytes is associated with the decrease in eosinophil peroxidase activity, while the increase in IL-5 and TNFα secretory reactivity is connected with oppositely directed changes in  IL-2 basal secretion by eosinophils in vitro (a fall in infiltrative TB and a rise in disseminated TB).
ULTRASTRUCTURE OF SYNAPSES IN THE HIPPOCAMPUS OF RATS IN AGING
Authors: Maksimova K. Yu. , Logvinov S. V. , Stefanova N. A.
Published: June 2020

The aim of the study was to examine age-related changes in the ultrastructure of synapses in the CA1 region of the hippocampus of Wistar rats and premature aging OXYS rats.

To assess changes of the sinaptoarhitectonics photographed on 15 randomly chosen fields of view of the pyramidal layer of the CA1 region of the hippocampus with five slices at a standard magnification of 10000. It was determined the amount of mineral contacts (size of the field of view is 50 μm2) and calculated numerical density of synapses per 100 μm2. The number of contacts with asymmetric and symmetric organization sistemasubsidiaries units, perforated, hypertrophic contacts are counted.

The study showed that there are significant differences in the ultrastructural organization of the synapses between the lines, already 4 months old. The numerical density of snaps in this age group OXYS rats was significantly higher than that of Wistar. Ultrastructure of synapses in the CA1 region of the hippocampus of rats at the age of 18 months more bulupodadan pathological essentiaompetencies processes and membrane prematurely senescent rats in contrast to the control line. The numerical indicator of protect contents 18-month-old rats OXYS was significantly lower than in Wistar.

Identified interstrain differences in the degree of changes of synapses can testify in favor of a different sensitivity to oxidative stress in rats investigated lines.
COMPUTER SIMULATION OF GLICOPHORIN A AND 4-METHYL-2,6-DIISOBORNILFENOL INTERACTION BY AUTODOCK AND HEXSERVER PROGRAMS
Authors: Ostrikova O. I.
Published: June 2020

4-methyl-2,6-diisobornilphenol (dibornol) – a promising drug with a hemorheological activity. Glycophorin A is one of erythrocyte membrane proteins involved in the aggregation and possibly mediating rheological effects of dibornol.

Objective: to conduct a modeling of the interaction dibornol and glycophorin A by AutoDock and HexServer programs.

Material and methods. We used three-dimensional models of molecules dibornol and glycophorin A. Information on the three-dimensional model of glycophorin A was received from the database RCSB Protein Data Bank – 1AFO. Modeling the three-dimensional model of a dibornol (4-methyl-2,6- diisobornilfenol) was modeling by PRODRG Server.

Results. This paper presents the results of computer modeling of interaction dibornol and glycophorin A by HexServer and AutoDock programs. We used the electrostatic properties of the molecule glycophorin A, site of interaction is position chain A VAL83, chain B – ALA82, GLY83, GLY86, THR87. The energy of binding was –6.73 kcal/mol by AutoDock program, HexServer – –2.89 kcal/mol. The charge of the molecular complex dibornol-glycophorin A decreased to –4.126 (the charge of the native molecule glycophorin A – –4.003).

Conclusion. Integrated use of the program AutoDock and HexServer helps significantly reduce the time and computational resources in the modeling. The study identified the amino acids that may play a key role in the interaction with dibornol glycophorin A. This study has given us reason to believe that as a result of such interaction dibornol may prevent adhesion of red blood cells.
STREPTOCOCCUS PNEUMONIAE MOLECULAR EPIDEMIOLOGICAL FEATURES IN CHILDREN OF KRASNOYARSK REGION
Authors: Protasova I. N. , Bakhareva N. V. , Peryanova O. V. , Yelistratova T. A. , Koval M. V.
Published: June 2020

The purpose of the research was to estimate the prevalence of Streptococcus pneumoniae nasopharyngeal carriage in 250 children aged under 5 years and 215 school-aged children in Krasnoyarsk Region, and also investigate molecular epidemiological features of the strains circulating inKrasnoyarsk city and in Krasnoyarsk Region. This study is carried out for the first time in the region and provides a foundation for the choice of optimal vaccination strategy of pneumococcal disease.

S. pneumoniae identification was carried out using culture method as well as PCR (revealing of cpsA gene), serotypes were determined with PCR (according to CDC protocol).

The prevalence of S. pneumoniae carriage in under-five children was 51,6% with predominated pneumococcal serotypes 23F, 19F and 6В; most of these strains (up to 90%) belonged to those included in pneumococcal vaccines which are permitted for use in Russian Federation; the greatest conformity was observed in 13-valent conjugated vaccine. In school-aged children the S. pneumoniae prevalence was 12,1% with predominated pneumococcal serotypes 6В, 9VA and 15АF, most of these strains (up to 60%) belonged to those included in approved pneumococcal vaccines.

Considering high level of S. pneumoniae carriage in children under 5 years in organized groups and unorganized children from families with two or more children it is necessary to carry out vaccine prevention of pneumococcal diseases with of 13-valent pneumococcal conjugated vaccine application.
THE GLUTATHIONE SYSTEM IS INVOLVED IN REGULATION OF TUMOR CELLS APOPTOSIS
Authors: Ryazantseva N. V. , Nosareva O. L. , Stepovaya Ye. A. , Zakirova Ye. V. , Naumova A. I. , Vesnina O. N. , Shakhristova Ye. V. , Orlov D. S. , Yakushina V. D. , Novitsky V. V.
Published: June 2020

The research objective is to determine the role of the gluthatione system components in realization of the receptor pathway of Jukart tumor cell apoptosis.

Apoptosis realization using FITC-labeled annexin V and propidium iodide as well as the amount of TNF R1- and Fas-presenting cells has been evaluated by flow cytofluorometry; activity caspase-3 registered a spektroflyuorimetrichesky method. The concentration of reduced and oxidated gluthatione has been determined by spectrophotometry.

The material for the research was intact Jukart tumor cells and the ones incubated in the presence of a selective inhibitor of the key gluthatione synthesis enzyme – buthionine-sulfoximine.

The research has shown that the gluthatione system plays an important regulatory role in activation of the receptor pathway of Jukart tumor cell apoptosis.The gluthatione system components are targets for activation of programmed cell death in tumor growth.
RATING SYSTEM FOR THE KNOWLEDGE AND SKILLS CONTROL AND ITS REALIZATION IN THE LEARNING ENVIRONMENT “MOODLE”
Authors: Arzhanik M. V. , Vorobyeva N. V. , Ostrikova O. I. , Karas S. I.
Published: June 2020

Rating control of students knowledge and skills is the part of Bologna declaration of European Universitites. Optimal realization of rating system brings together the objectivity and the individual approach to student’s evaluation. Analysis of rating control possibilities in medical University and peculiarities of individual rating adaptation in the LMS Moodle are the objectives of this paper.LMS Moodle contains enough elements quantity for evaluation and allows sum up of learning course results. First level of rating system adaptation is various intervals for different course elements. Weight coefficients for learning tasks mean second one. Third rating adaptation level is the method of calculation of final rating score for a student. There is example of rating system in medical informatics course for medical and pediatric students in the paper. Organizational, technological and financial aspects of rating introducing in the medical education are discussed.
PSYCHOLOGICAL MECHANISMS OF FORMATION OF DEVIATIONS IN THE PERIOD OF PREPARATION FOR MOTHERHOOD
Authors: Moreva S. A. , Silaeva A. V. , Kornetov A. N. , Borodina Ye. N. , Yankovskaya A. Ye. , Pryadukhina N. I. , Golovakha N. E. , Obukhovskaya V. B.
Published: June 2020

The article presents a social-psychological indicators of stress, coping mechanisms, rigidity and psychological component gestational dominant as risk factors predisposing to deviations in the context of preparedness for motherhood, marked psychological characteristics of pregnant women main group.Material and methods. The study was conducted on the basis of obstetric clinics SSMU, prenatal maternity hospital number 4 and the Centre for Medical Prevention (Cabinet crisis pregnancy). Total was attended by 52 women aged 18 to 44 years, at different stages of pregnancy – from 5 to 39 weeks. Methodological apparatus consisted of a structured interview questionnaire “Medical and social data of the pregnant woman” methodology for determining the stress and social adaptation of Holmes and Rage (1967), a questionnaire of coping R. Lazarus and S. Folkman (WCQ, 1988), Tomsk questionnaire rigidity G.V. Zalewski (TORZ, 1987), test on pregnant I.V. Dobryakova (1996). Data processing was carried out using statistical methods Spearman rank correlation coefficient, nonparametric Mann–Whitney U and Kruskal–Wallis H and φ * – Fisher's angular transformation.Results. Significant psychological factors that may influence the formation of readiness for motherhood among women of the main group can be considered an unplanned pregnancy (65%), and also its not gelendost (35%).Studies of stress resistance was detected in pregnant women from the main group low stress levels (88%), and only 12% have a high degree. Most of the women from the сomparison group reverse the situation 64% have a high degree of stress, this suggests that the presence of previously state miscarriage is for this group of stress.On the formation of readiness for motherhood affects not only the presence of stressful situations, butalso how the woman in their lives. Using U-test Mann–Whitney, were statistically significant differences were observed among the main group and сomparison group in the following coping strategies: selfcontrol (p ≤ 0.0014), the search for social support (p ≤ 0.0015), accepting responsibility (p ≤ 0.04), and planning solutions to the problems (p ≤ 0.00016). These differences are considered as one of the risk factors for deviant motherhood main group.In contrast to the сomparison group, where 62% of pregnant women with the optimal type PKGD, main group optimal type PKGD observed only in 38% of the respondents, which indicates that the risk of deviations in the structure of psychological readiness.Conclusion. Risk factors such as social disadvantage, the planned abandonment of a child, the tendency to rigid behavior, inefficient use of coping strategies and low level of optimal psychological component gestational dominant testify about the possible psychological unpreparedness for the upcoming event to become a mother and as a consequence to the development of deviant motherhood.
CLINICAL AND SOCIAL RISK FACTORS OF TARDIVE DYSKINESIA IN PATIENTS WITH SCHIZOPHRENIA DURING ANTIPSYCHOTIC TREATMENT
Authors: Kornetova Ye. G. , Semke A. V. , Dmitrieva Ye. G. , Borodyuk Yu. N. , Boyko A. S.
Published: June 2020

The purpose of the present work was to study the clinical features and risk factors of tardive dyskinesia among     the     schizophrenia     patients     who     durably     receive     the     antipsychotic     therapy. 180 of the 18 to 65 age bracket schizophrenia patients, who were treated in a residential psychiatric treatment facility, were examined with the use of the Positive and Negative Syndrome Scale (PANSS), Abnormal Involuntary Movement Scale (AIMS), and the basic chart of formalized sociodemographic and clinico-dynamic features developed at the Tomsk Mental Health Research Institute. The acquired data were processed by the Mann–Whitney U-Test and χ2. The average age of the tardive dyskinesia patients  turned out to be conclusively older than that of the patients without this derangement. People who have tardive dyskinesia statistically often happen to be single in comparison with other variants of marital status. It was found out that women happen to have tardive dyskinesia more often, which allows us to see the female gender as a risk factor. The tardive dyskinesia patients had certain negative symptoms. The patients were arranged into groups according to the prepotency of symptom-complexes over the subgroups: with orofacial, thoracolumbar and combined tardive dyskinesia. The average age of the orofacial dyskinesia patients turned out to be conclusively older than that of the patients without tardive dyskinesia. The negative symptoms level in the subgroup was conclusively higher than among those without tardive dyskinesia. The average age of the thoracolumbar dyskinesia patients was conclusively older than that of the patients without tardive dyskinesia. The average age of the combined dyskinesia patients was conclusively older than the patients without the tardive dyskinesia. The patients having schizophrenia for longer than 10 years prevailed in the combined dyskinesia group. Such characteristics as education level and social status, age of when the medical problem started, dominance of the positive symptoms, duration of antipsychotic agents administration, somatic condition, use of psychoactive substances, suicidal and hetero-aggressive behaviors make no contribution to the risk of tardive dyskinesia development in the presence of schizophrenia, and they are not protective factors either.
RESULTS OF SURGICAL TREATMENT OF INFANTILE AND JUVENILE SCOLIOSIS USING VARIOUS INSTRUMENTATION
Authors: Mikhailovsky M. V. , Suzdalov V. A. , Dolotin D. N. , Udalova I. G.
Published: June 2020

Introduction. The analysis Results of surgical treatment of growing children with infantile and juvenile scoliosis (IS) can the optimal method of treatment select. In young children with significant growth potential spinal fusion may not be the best option as it limits further longitudinal growth of the spine and may to the thoracic insufficiency syndrome result. To address this problem recently several techniques focused, their have advantages and drawbacks.Material and methods. Since 2008 year 127 patients (64 girls, 63 boys) aged (4.5 ± 2.1) years were operated on. In group I 65 patients were operated on using VEPTR (Vertical Expandable Prosthetic Titanium Rib) instrumentation, in group II 42 patients using various spinal instrumentation. 20 patients with congenital kyphosis were excluded. The average follow-up time was (5.6 ± 1.1) years.Results. In group I average value of the primary scoliotic curve before surgery was (74.7 ± 22.9), secondary curve (42.8 ± 16.0), thoracic kyphosis (46.3 ± 27.4), lumbar lordosis (54.6 ± 14). Average value of the primary scoliotic curve after surgery was reduced to (51 ± 20) (correction 31.7%), at followup to (56.5 ± 18.5), secondary curve (31.8 ± 12.8) (25.7%), at follow-up to (32.4 ± 18.4), thoracic kyphosis (36.8 ± 20.8) (20,5%), at follow-up to (41.8 ± 21.0), lumbar lordosis (45.4 ± 12.7) (16,9%), at follow-up to (48.2 ± 11.7) (p < 0.05). Space available for lung before surgery was (84.5 ± 8.7) %, after surgery was (94.8 ± 6.7)%, at follow-up increased to (98.6 ± 5.4) % (p < 0.05). Complications included 11 implant dislocations and 1 infection. In group II average value of the primary scoliotic curve before surgery was (87.6 ± 6.6), secondary curve (47.8 ± 4.6), thoracic kyphosis (61.4 ± 10.4), lumbar lordosis (61.8 ± 4.9). Average value of the primary scoliotic curve after surgery was reduced to 50.6 ± 5.3 (correction 42.3%), at follow-up to (66.1 ± 6.3), secondary curve (24.1 ± 2.9) (49.6%), at follow-up to (37 ± 5.4), thoracic kyphosis (38.8 ± 7.7) (36.8%), at follow-up to (59.4 ± 11.2), lumbar lordosis (47.5 ± 4.1) (23.2%), at follow-up to (64.5 ± 4.5) (p < 0.05). Complications included 23 implant dislocations and 1 infection. No neurological complications.Conclusion. Stage correction fusions using various instrumentation is a method of choice for controlled correction of growing children with IS.
SURGICAL METHODS OF TREATMENT OF PATIENTS WITH FORMED PANCREATIC CYSTS
Authors: Merzlikin N. V. , Sled N. Yu. , Popov A. Ye. , Tskhaj V. F. , Brazhnikova N. A. , Shelepov S. V. , Podgornov V. F. , Gyunter V. E. , Kapustinsky A. N. , Bushlanov P. S.
Published: June 2020

Objective: a comparative analysis of the results of the use of different surgical methods of treatment of patients with formed pancreatic cysts.Material and methods. 108 patients with formed pancreatic cysts were treated and analysis of shortand long-term results of their surgical treatment was performed. Patients were divided into three groups depending on the type of surgical intervention: I – external drainage – 44 (40.7%), II – internal drainage –33 (30.6%), III – resection operations – 31 (28.7%).Results and discussions. Marsupialization of cyst by laparotomy incision was performed in patients of I group (n = 44). 18 (40.9%) complications, 9 (20.5%) lethal cases were after operation. Anastomoses of cysts with the small intestine were mostly performed in II group (n = 33) – 21 (63.6%). 7 (21.2%) complications, 1 (3.0%) lethal case were after operation. Distal resections were performed in patients of III group (n = 31) in 16 (51.6%) cases. Duodenum-preserving resections were introduced for treatment of cyst of pancreas head – 12 (38.7%). When performing this type of operations we proposed nikelid titanium stents for the prevention of anastomosis stenosis and preoperative retrograde stenting of the common bile duct for the prevention of damage. 10 (32.3%) complications and no lethal cases were after operation. Immediate results were worse in patients of I group. 47 (43.5%) patients were analyzed in long-term period. The number of recurrences of the disease (13.3%) and long-term mortality (33.3%) prevailed in the group of patients undergoing internal drainage of cysts. Quality of life, level of mental and physical health, that was assessed using SF-36, were higher in group of patients with reactionary treatment.Conclusion. The best immediate and long-term results were noted after resection operations, that enables to recommend their as the most optimal and radical method for treatment of patients with pancreatic cysts. Introducing of duodenum-preserving resections in case of pancreas head cyst improves the quality of patients life.
EFFECT OF SILVER NANOPARTICLES IN EXPERIMENTAL PERITONITIS
Authors: Chegodar D. V. , Kubyshkin A. V. , Panasenko V. V.
Published: June 2020

In our research we have investigated the effect of intraperitoneal introduction of silver nanoparticles solution (linear particle size of 10–20 nm) into intact animals and in the simulation of experimental peritonitis. We have evaluated the indices of nonspecific proteinases and their inhibitors in blood serum and peritoneum lavage. The intraperitoneal introduction of silver nanoparticles solution to intact animals leads to the minimal reaction of proteinase-inhibitor systems components in blood serum and peritoneum lavage. When modeling inflammatory process in peritoneum cavity by intraperitoneal injection of 10% filtered fecal suspension of rats, application of silver nanoparticles solution is accompanied by decrease in extent of activation of proteinases and preservation of inhibitory potential, both at systemic and local level, which can indicate antiinflammatory effects of nanosilver.
INFLUENCE OF HERBAL EXTRACTS ON METABOLIC DISTURBANCES IN DIABETES MELLITUS AND INSULIN RESISTANCE MODEL
Authors: Yakimova T. V. , Nasanova O. N. , Vengerovsky A. I.
Published: June 2020

The aim of this research was to assess the influence on metabolic processes of herbal extracts, used in diets with different fat content, in diabetes mellitus and insulin resistance model.Material and methods. The experiments were performing on 90 noninbred male albino rats. Diabetes mellitus was modeling with twice-repeated intraperitoneal streptozotocine (30 mg/kg) injections. For the insulin resistance formation animals were fad meal with 30% fat content. Against the background rats were administering into the stomach nettle leafs (Urtica dioica L., 100 mg/kg), burdock roots (Arctium lappa L., 25 mg/kg) extracts or intraperitoneal insulin preparation Actrapide HM Penfill (3 mg/kg) daily during 10 days. During period of agents introduction one-half of animals continued to receive food with high fat content, the other half received diet with 8% fat content. The third rats group received only food with low fat content without extracts or insulin administration. In blood was measured the glucose, glycosylated hemoglobin, creatinine, urea, uric acid content, in liver homogenates – glycogen, protein content, aminotransferases and glucose-6phosphatase activity, in muscle homogenates – glycogen and protein content.Results. After streptozotocine injections and diet with 30% fat content the blood glucose level became by 4.0–5.3 fold more than level of intact animals, increased the hemoglobin glycosylation, also creatinine, urea, uric acid blood content, in liver and muscle homogenates raised glycogen content, decreased protein quantity, in liver homogenates increased aminotranferases and glucose-6-phosphatase activity. In animals only feeding with 8% fat diminished hyperglycemia, creatinine blood retention, the liver glycogen content and recovered its protein resources. The nettle or burdock extracts administrating to animals that continued to receive high fat meal decreased the blood glucose, glycosylated hemoglobin and creatinine content, the liver glucose-6-phosphatase activity, increased the muscle protein content, the nettle extract also prevented from hyperuricemia and liver protein deficiency, the burdock extract caused the liver glycogen accumulation. In animals feeding with low fat meal the nettle extract caused hyperglycemia parameters regression and changed in the direction of the norm the liver and muscle glycogen content, the burdock extract decreased only hemoglobin glycosylation, both herbal extracts decreased the blood creatinine level and increased the muscle protein level. Independently of diet the nettle extract increased the insulin sensitivity after 60 and 120 min after insulin injection, the burdock extract – after 120 min.Conclusion. The nettle and burdock extracts have in diabetes mellitus and insulin resistance model hypoglycemic action, prevent from hemoglobin glycosylation, improve creatinine excretion, recover the muscle sensitivity to insulin effect.
ETIOLOGY AND PATHOGENESIS OF RETINAL VEIN OCCLUSION: THE ACTUAL STATE OF A PROBLEM
Authors: Krylova A. A. , Zapuskalov I. V. , Krivosheina O. I.
Published: June 2020

The review presents the actual questions of the etiopathogenesis of central retinal vein occlusion and its branches. It was found that predictors of disease is a pathology of haemostasis, including asymptomatic gene mutations of coagulation factors and platelet receptors, chronic viral infections, rheumatological and oncological diseases, hypertension, metabolic disorders, smoking, physical inactivity, inflammatory diseases of the retinal and optic nerve, congenital and acquired abnormalities of retinal vascular, glaucoma.The article also focused on the reasons for the formation of a blood clot. This is damage to the vascular wall, slowing the speed of blood flow in the vessel, hypercoagulation and hypofibrinolysis. Prevailing theories of the pathogenesis of retinal vein occlusion are analyzed. This is mechanical and theory “coag- ulopathy” whose arguments and counterarguments are discussed in detail. In addition, patients with reti- nal vein occlusion are needed in a multidisciplinary approach to the treatment of this disease. It is to im- prove the clinical and functional results of therapy and prevent the case of retrombosis.
MECHANISMS OF COUNTERACTING FLAP-VALVE BRONCHIAL OBSTRUCTION IN CASE OF OBSTRUCTIVE PULMONARY EMPHYSEMA
Authors: Tetenev K. F. , Tetenev F. F. , Ageyeva T. S. , Bodrova T. N. , Karzilov A. I. , Mesko P. Ye.
Published: June 2020

The research goal was to formulate and substantiate the hypothesis explaining support for an expiratory air flow in case of pulmonary emphysema. The research method consisted in comparing the mechanical properties of lungs in practically healthy individuals (37 individuals, mean age – (30.4 ± 1.7) y.o.) and COPD patients with pronounced lung emphysema (30 patients, mean age – (52.1 ± 2.3) y.o.) as well as those of isolated normal lungs (n = 14) and isolated lungs of patients who died of COPD (n = 5). Pulmo-nary mechanics was studied via the simultaneous measurement of transpulmonary pressure and lung ven-tilation volume. General lung hysteresis and elastic lung hysteresis were calculated. The mechanical properties of isolated lungs were studied using passive ventilation under the Donders bell. The air flow was interrupted in order to measure alveolar pressure and develop an elastic lung hysteresis curve. Pres-sure in the Donders bell was changed by means of a special pump in automatic and manual modes. The research has not revealed any fundamental differences between the mechanical properties of the normal and emphysematous lungs. A minimum increase in the pressure inside the Donders bell over atmospheric pressure used to stop air ejection in both normal and the emphysematous lungs as the result of flap-valve bronchial obstruction. In living beings, air is ejected from lungs with an increase in pressure under the conditions of forced expiration. Pressure increases up to (38.6 ± 2.71) cm H2O in healthy individuals and up to (20.5 ± 1.86) cm H2O in COPD patients. Probably, an expiratory air flow is supported by active expiratory bronchial dilatation that counteracts flap-valve bronchial obstruction. The hypothesis is based on the confirmed ability of the lungs to perform inspiratory actions (in addition to the action of respiratory muscles) and the theory of mechanical lung activity.
СHARACTERISTICS OF THE HEART FATTY ACID-BINDING PROTEIN, INTERLEUKIN-6 AND INTERLEUKIN-8 AS ALTERNATIVE MARKERS OF DIABETIC NEPHROPATHY PROGRESSION IN PATIENTS WITH TYPE 1 DIABETES MELLITUS
Authors: Ryzhikova Yu. A. , Vorozhtsova I. N. , Saprina T. V. , Zavadovskaya V. D. , Merinov A. B. , Kulagina I. V.
Published: June 2020

The aim of this work was to study the levels of the heart fatty acid-binding protein (h-FABP), interleukin6 (IL-6) and interleukin-8 (IL-8), in diabetic nephropathy (DN) in patients with type 1 diabetes mellitus (T1DM). Material and methods. We examined 87 patients aged 18 to 54 with T1DM within the study group. 30 patients with type 1 diabetes were diagnosed with normoalbuminuria, 29 patients – with microalbuminuria and 28 patients – with proteinuria. The control group consisted of 24 healthy donor aged 22 to 29. The comparison group included 22 patients aged 20 to 42 with verified diagnosis of essential arterial hypertension (AH) without carbohydrate metabolism disorders. The daily urinary albumin excretion was determined by immunoturbidimetric technique. 30 patients with type 1 diabetes were diagnosed with normoalbuminuria, 29 patients – with microalbuminuria and 28 patients with proteinuria.Calculation of glomerular filtration rate was performed according to the Hoek formula with the use of cystatinС serum concentrations. Contents of h-FABP, IL-6 and cystatin C in serum and h-FABP, IL-8 inurine were determined by enzyme-linked immunosorbent assay. Results. Analysis of the h-FABP content in serum showed that the concentration of this marker in individuals with T1DM was higher than in patients of the control group and the comparison group. Analysis of the h-FABP content in the urine revealed that individuals with essential hypertension showed an increased level of h-FABP while patients with T1DM demonstrated the highest concentration of h-FABP. The concentration of IL-6 inindividuals with T1DM and in individuals with AH significantly exceeded the control values. The contents of h-FABP and IL-6 inserum and h-FABP and IL-8 inurine increased with the progression of DN and reached maximum in individuals of the proteinuria subgroup. At the same time, the levels of h-FABP and IL-8 inthe urine of patients in the microalbuminuria (MAU) subgroup were higher compared to those in individuals of the normoalbuminuria (NAU) subgroup. Noteworthy is the fact that the h-FABP content in the urine of individuals in NAU subgroup was higher compared to the control group. Furthermore, higher rates of h-FABP and IL-8 urinary excretions were observed in individuals with CKD stage 2 as compared to individuals with CKD stage1 inthe MAU subgroup. Conclusion. Thus, the results obtained in the course of the study indicate that h-FABP and IL-8 can be considered as alternative markers of DN progression in patients with T1DM.
50 ANNIVERSARY OF THE TRAVMATOLOGY, ORT CHAIR OF SIBERIAN STATE MEDICAL UNIVERSITY
Authors: Perveev V. I.
Published: June 2020

The history of formation and development of the Department of traumatology and orthopedics, military surgery of Siberian State Medical University for 50 years has been presented. Information about the scientists who have made contributions to the theory and practice of traumatology and orthopedics, the training of medical staff are given. The main directions of scientific and practical activities are shown.
ENDOTHELIAL DYSFUNCTION IN STABLE ANGINA AND MYOCARDIAL INFARCTION COMBINED WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE
Authors: Popova M. A. , Terentyeva N. N. , Dolgopolova D. A. , Marenina T. V.
Published: June 2020

The research objective is to determine the state of endothelium-dependent and endothelium-independent vasodilatation in patients with coronary heart disease (CHD) associated with chronic obstructive pulmonary disease (COPD).

Material and methods.In the cross-sectional study included 122 patients with CHD associated with COPD: 68 people of them are patients with stable angina without acute coronary events in history and 54 patients with acute ST segment elevation myocardial infarction (STEMI). Comparison group comprised 53 patients with stable angina and 51 patients after STEMI without concomitant COPD. Patients were included if they met the following inclusion criteria: male, age <60 years, verified forms of CHD (stable angina, STEMI), documented with COPD without exacerbation and forced expiratory volume in 1 second > 30% in the groups with CHD and COPD. Arterial endothelial function was tested with high-resolution ultrasonography: brachial artery diameter was measured at rest, after flow increase (which causes endothelium-dependent dilatation), and after administration of sublingual nitroglycerin (an endothelium-independent dilator).

Results.We found that endothelial dysfunction in patients with acute and chronic forms of CHD in combination with COPD are more pronounced than in isolated CHD.

Conclusion.Expressed depression functional vascular reserve in patients with CHD associated with COPD, should be taken into account when conducting individualized therapy of these patients.