bluuebunny/crossref_metadata_2025 huggingface dataset:
Investigation on the Therapeutic Effect of Polygonum multiflorum Thunb. in Chronic Stress-Induced Hair Loss in Mice Coupled with Metabolomics and Proteomics
Authors: Zhao Yong-Kang , Guo Rui-Xian , Li Rui-Sheng , Shi Wei , Gong Hai-Ying , Ma Run-Ran , Gao Han , Li Zhen , Hu Ke-Jian , Bai Zhao-Fang , Xiao Xiao-He , Zang Qing-Ce , Kong Wei-Jun , Li Peng , Niu Ming , Wang Jia-Bo , Gao Yuan
Published: May 2024

Objective:

Stress is the main factor that leads to hair loss, and no effective therapeutics have been developed for stress alopecia. Polygonum multiflorum Thunb. (PM) is a famous traditional Chinese medicine for tonifying the kidney and nourishing the liver, which is used to treat hair loss. This study aimed to demonstrate that PM is a promising agent for the treatment of chronic stress-induced hair loss.

Materials and Methods:

C57BL/6J male mice were subjected to chronic restraint stress to inhibit hair follicle growth. Subsequently, the effect of PM was examined by oral administration of the PM water extract or cortisone, followed by histological analysis, immunofluorescence of follicle samples, serum metabolomics, and adrenal proteomics.

Results:

Hair regeneration in a mouse model was severely inhibited by chronic restraint stress. After PM treatment, hair regeneration in model mice was promoted, including an increased length of hair shafts in skin sections, an increased number of 5-Ethynyl-2’-deoxyuridine-positive cells, and a decreased number of apoptotic cells around the hair follicles. The various test indicators of these PM-treated mice almost recovered to levels comparable to those of the control mice. Through metabolomics and proteomics analyses, we identified 181 endogenous differential metabolites and 75 differential proteins, which may be the potential targets for PM. Pathway enrichment analysis showed that steroid biosynthesis (the main pathway through which stress leads to an imbalance in glucocorticoid secretion by the adrenal gland) may play an important role in the therapeutic effects of PM. In addition, omics analysis revealed that glycolysis/gluconeogenesis, pyruvate metabolism, lipid metabolism, and other glucocorticoid-related metabolic pathways differed significantly after PM treatment.

Conclusions:

PM is an important natural drug that regulates hair regeneration in mice under stress, and its underlying mechanism is closely related to the regulation of adrenal glucocorticoids and their metabolism.
Research on 2D Animation Simulation Based on Artificial Intelligence and Biomechanical Modeling
Authors: Fangming Dai  , Li Zhiyong
Published: May 2024

Animation techniques have been completely transformed by the union of Artificial Intelligence (AI) and biomechanical modeling, particularly in 2D animation. This study looks at a combination of AI and biomechanics to address the challenges of simulating 2D animation. Current approaches in 2D animation often struggle to achieve lifelike and fluid movements, especially when representing complex motion or interaction. These traditional techniques rely on manual keyframing or physics simulation, which may be time-consuming and do not provide the rich detail needed for realism in animations. To meet these aspects, this study suggested 2D animation using Artificial Intelligence with Biomechanical Modeling (2D-AI-BM). Our approach thus harnesses Deep Neural Network (DNN) for moving forecasts and improvement using biopsychological principles to help us imitate natural human actions better. In addition to character animation, it could apply to interactive storytelling and educational simulations. As a result, animators get more control over motion generation while drastically reducing the necessity for manual intervention through this fusion of AI and biomechanics, which smoothens the production pipeline for animations. This paper considers several important metrics to evaluate the proposed approach’s effectiveness, including user satisfaction, computational efficiency, motion smoothness and realism. Comparative studies with classical animation methods showed that the method generates realistic movements on 2D characters while saving time during production. The numerical findings exemplify that the recommended 2D-AI-BM model improves an accuracy rate of 97.4%, computational efficiency ratio of 96.3%, motion control ratio of 95.4%, pose detection ratio of 94.8% and scalability ratio of 93.2% compared to other popular techniques.
GLI1 and PTTG1 expression in colorectal carcinoma patients undergoing radical surgery and their correlation with lymph node metastasis
Authors: Cao Feng , Chen Yang-Yan , Wang Hong-Cheng
Published: May 2024

BACKGROUND

Few studies have investigated the expression of GLI1 and PTTG1 in patients undergoing radical surgery for colorectal carcinoma (CRC) and their association with lymph node metastasis (LNM). Therefore, more relevant studies and analyses need to be conducted.

AIM

To explore GLI1 and PTTG1 expression in patients undergoing radical surgery for CRC and their correlation with LNM.

METHODS

This study selected 103 patients with CRC admitted to our hospital between April 2020 and April 2023. Sample specimens of CRC and adjacent tissues were collected to determine the positive rates and expression levels of GLI1 and PTTG1 . The correlation of the two genes with patients’ clinicopathological data (e.g., LNM) was explored, and differences in GLI1 and PTTG1 expression between patients with LNM and those without were analyzed. Receiver operating characteristic (ROC) curves were plotted to evaluate the predictive potential of the two genes for LNM in patients with CRC.

RESULTS

Significantly higher positive rates and expression levels of GLI1 and PTTG1 were observed in CRC tissue samples compared with adjacent tissues. GLI1 and PTTG1 were strongly linked to LNM in patients undergoing radical surgery for CRC, with higher GLI1 and PTTG1 levels found in patients with LNM than in those without. The areas under the ROC curve of GLI1 and PTTG1 in assessing LNM in patients with CRC were 0.824 and 0.811, respectively.

CONCLUSION

GLI1 and PTTG1 expression was upregulated in patients undergoing radical surgery for CRC and are significantly related to LNM in these patients. Moreover, high GLI1 and PTTG1 expression can indicate LNM in patients with CRC undergoing radical surgery. The expression of both genes has certain diagnostic and therapeutic significance.
Evaluating effectiveness and safety of combined percutaneous transhepatic gallbladder drainage and laparoscopic cholecystectomy in acute cholecystitis patients: Meta-analysis
Authors: Li Yu , Xiao Wei-Ke , Li Xiao-Jun , Dong Hui-Yuan
Published: May 2024

BACKGROUND

Acute cholecystitis (AC) is a common disease in general surgery. Laparoscopic cholecystectomy (LC) is widely recognized as the "gold standard" surgical procedure for treating AC. For low-risk patients without complications, LC is the recommended treatment plan, but there is still controversy regarding the treatment strategy for moderate AC patients, which relies more on the surgeon's experience and the medical platform of the visiting unit. Percutaneous transhepatic gallbladder puncture drainage (PTGBD) can effectively alleviate gallbladder inflammation, reduce gallbladder wall edema and adhesion around the gallbladder, and create a "time window" for elective surgery.

AIM

To compare the clinical efficacy and safety of LC or PTGBD combined with LC for treating AC patients, providing a theoretical basis for choosing reasonable surgical methods for AC patients.

METHODS

In this study, we conducted a clinical investigation regarding the combined use of PTGBD tubes for the treatment of gastric cancer patients with AC. We performed searches in the following databases: PubMed, Web of Science, EMBASE, Cochrane Library, China National Knowledge Infrastructure, and Wanfang Database. The search encompassed literature published from the inception of these databases to the present. Subsequently, relevant data were extracted, and a meta-analysis was conducted using RevMan 5.3 software.

RESULTS

A comprehensive analysis was conducted, encompassing 24 studies involving a total of 2564 patients. These patients were categorized into two groups: 1371 in the LC group and 1193 in the PTGBD + LC group. The outcomes of the meta-analysis revealed noteworthy disparities between the PTGBD + LC group and the LC group in multiple dimensions: (1) Operative time: Mean difference (MD) = 17.51, 95%CI: 9.53-25.49, P < 0.01; (2) Conversion to open surgery rate: Odds ratio (OR) = 2.95, 95%CI: 1.90-4.58, P < 0.01; (3) Intraoperative bleeding loss: MD = 32.27, 95%CI: 23.03-41.50, P < 0.01; (4) Postoperative hospital stay: MD = 1.44, 95%CI: 0.14-2.73, P = 0.03; (5) Overall postoperative complication rate: OR = 1.88, 95%CI: 1.45-2.43, P < 0.01; (6) Bile duct injury: OR = 2.17, 95%CI: 1.30-3.64, P = 0.003; (7) Intra-abdominal hemorrhage: OR = 2.45, 95%CI: 1.06-5.64, P = 0.004; and (8) Wound infection: OR = 0. These findings consistently favored the PTGBD + LC group over the LC group. There were no significant differences in the total duration of hospitalization [MD = -1.85, 95%CI: -4.86-1.16, P = 0.23] or bile leakage [OR = 1.33, 95%CI: 0.81-2.18, P = 0.26] between the two groups.

CONCLUSION

The combination of PTGBD tubes with LC for AC treatment demonstrated superior clinical efficacy and enhanced safety, suggesting its broader application value in clinical practice.
Sinomenine increases osteogenesis in mice with ovariectomy-induced bone loss by modulating autophagy
Authors: Xiao Hai-Xiang , Yu Lei , Xia Yu , Chen Kai , Li Wen-Ming , Ge Gao-Ran , Zhang Wei , Zhang Qing , Zhang Hong-Tao , Geng De-Chun
Published: May 2024

BACKGROUND

A decreased autophagic capacity of bone marrow mesenchymal stromal cells (BMSCs) has been suggested to be an important cause of decreased osteogenic differentiation. A pharmacological increase in autophagy of BMSCs is a potential therapeutic option to increase osteoblast viability and ameliorate osteoporosis.

AIM

To explore the effects of sinomenine (SIN) on the osteogenic differentiation of BMSCs and the underlying mechanisms.

METHODS

For in vitro experiments, BMSCs were extracted from sham-treated mice and ovariectomized mice, and the levels of autophagy markers and osteogenic differentiation were examined after treatment with the appropriate concentrations of SIN and the autophagy inhibitor 3-methyladenine. In vivo , the therapeutic effect of SIN was verified by establishing an ovariectomy-induced mouse model and by morphological and histological assays of the mouse femur.

RESULTS

SIN reduced the levels of AKT and mammalian target of the rapamycin (mTOR) phosphorylation in the phosphatidylinositol 3-kinase (PI3K)/AKT/mTOR signaling pathway, inhibited mTOR activity, and increased autophagy ability of BMSCs, thereby promoting the osteogenic differentiation of BMSCs and effectively alleviating bone loss in ovariectomized mice in vivo .

CONCLUSION

The Chinese medicine SIN has potential for the treatment of various types of osteoporosis, bone homeostasis disorders, and autophagy-related diseases.
GATA binding protein 2 mediated ankyrin repeat domain containing 26 high expression in myeloid-derived cell lines
Authors: Jiang Yang-Zhou , Hu Lan-Yue , Chen Mao-Shan , Wang Xiao-Jie , Tan Cheng-Ning , Xue Pei-Pei , Yu Teng , He Xiao-Yan , Xiang Li-Xin , Xiao Yan-Ni , Li Xiao-Liang , Ran Qian , Li Zhong-Jun , Chen Li
Published: May 2024

BACKGROUND

Thrombocytopenia 2, an autosomal dominant inherited disease characterized by moderate thrombocytopenia, predisposition to myeloid malignancies and normal platelet size and function, can be caused by 5’-untranslated region (UTR) point mutations in ankyrin repeat domain containing 26 (ANKRD26). Runt related transcription factor 1 (RUNX1) and friend leukemia integration 1 (FLI1) have been identified as negative regulators of ANKRD26 . However, the positive regulators of ANKRD26 are still unknown.

AIM

To prove the positive regulatory effect of GATA binding protein 2 (GATA2) on ANKRD26 transcription.

METHODS

Human induced pluripotent stem cells derived from bone marrow (hiPSC-BM) and urothelium (hiPSC-U) were used to examine the ANKRD26 expression pattern in the early stage of differentiation. Then, transcriptome sequencing of these iPSCs and three public transcription factor (TF) databases (Cistrome DB, animal TFDB and ENCODE) were used to identify potential TF candidates for ANKRD26 . Furthermore, overexpression and dual-luciferase reporter experiments were used to verify the regulatory effect of the candidate TFs on ANKRD26 . Moreover, using the GENT2 platform, we analyzed the relationship between ANKRD26 expression and overall survival in cancer patients.

RESULTS

In hiPSC-BMs and hiPSC-Us, we found that the transcription levels of ANKRD26 varied in the absence of RUNX1 and FLI1. We sequenced hiPSC-BM and hiPSC-U and identified 68 candidate TFs for ANKRD26 . Together with three public TF databases, we found that GATA2 was the only candidate gene that could positively regulate ANKRD26 . Using dual-luciferase reporter experiments, we showed that GATA2 directly binds to the 5’-UTR of ANKRD26 and promotes its transcription. There are two identified binding sites of GATA2 that are located 2 kb upstream of the TSS of ANKRD26 . In addition, we discovered that high ANKRD26 expression is always related to a more favorable prognosis in breast and lung cancer patients.

CONCLUSION

We first discovered that the transcription factor GATA2 plays a positive role in ANKRD26 transcription and identified its precise binding sites at the promoter region, and we revealed the importance of ANKRD26 in many tissue-derived cancers.
Hepatocyte growth factor enhances the ability of dental pulp stem cells to ameliorate atherosclerosis in apolipoprotein E-knockout mice
Authors: Duan Han , Tao Ning , Lv Lin , Yan Kai-Xin , You Yong-Gang , Mao Zhuang , Wang Chang-Yao , Li Xue , Jin Jia-Yan , Wu Chu-Tse , Wang Hua
Published: May 2024

BACKGROUND

Atherosclerosis (AS), a chronic inflammatory disease of blood vessels, is a major contributor to cardiovascular disease. Dental pulp stem cells (DPSCs) are capable of exerting immunomodulatory and anti-inflammatory effects by secreting cytokines and exosomes and are widely used to treat autoimmune and inflammation-related diseases. Hepatocyte growth factor (HGF) is a pleiotropic cytokine that plays a key role in many inflammatory and autoimmune diseases.

AIM

To modify DPSCs with HGF (DPSC-HGF) and evaluate the therapeutic effect of DPSC-HGF on AS using an apolipoprotein E-knockout (ApoE-/-) mouse model and an in vitro cellular model.

METHODS

ApoE-/- mice were fed with a high-fat diet (HFD) for 12 wk and injected with DPSC-HGF or Ad-Null modified DPSCs (DPSC-Null) through tail vein at weeks 4, 7, and 11, respectively, and the therapeutic efficacy and mechanisms were analyzed by histopathology, flow cytometry, lipid and glucose measurements, real-time reverse transcription polymerase chain reaction (RT-PCR), and enzyme-linked immunosorbent assay at the different time points of the experiment. An in vitro inflammatory cell model was established by using RAW264.7 cells and human aortic endothelial cells (HAOECs), and indirect co-cultured with supernatant of DPSC-Null (DPSC-Null-CM) or DPSC-HGF-CM, and the effect and mechanisms were analyzed by flow cytometry, RT-PCR and western blot. Nuclear factor-κB (NF-κB) activators and inhibitors were also used to validate the related signaling pathways.

RESULTS

DPSC-Null and DPSC-HGF treatments decreased the area of atherosclerotic plaques and reduced the expression of inflammatory factors, and the percentage of macrophages in the aorta, and DPSC-HGF treatment had more pronounced effects. DPSCs treatment had no effect on serum lipoprotein levels. The FACS results showed that DPSCs treatment reduced the percentages of monocytes, neutrophils, and M1 macrophages in the peripheral blood and spleen. DPSC-Null-CM and DPSC-HGF-CM reduced adhesion molecule expression in tumor necrosis factor-α stimulated HAOECs and regulated M1 polarization and inflammatory factor expression in lipopolysaccharide-induced RAW264.7 cells by inhibiting the NF-κB signaling pathway.

CONCLUSION

This study suggested that DPSC-HGF could more effectively ameliorate AS in ApoE-/- mice on a HFD, and could be of greater value in stem cell-based treatments for AS.
Public finance instruments and output growth in Nigeria
Authors: Arodoye Nosakhare Liberty
Published: May 2024

This study investigates the empirical relationship between the aggregated and disaggregated components of fiscal policy variables and output growth in Nigeria using the vector error correction mechanism for the period of 1981 to 2021. This formulation was an improvement over previous empirical studies of the impact of public finance instruments on output growth in Nigeria. Our findings suggest that fiscal policy instruments (total expenditure, capital expenditure, recurrent expenditure, total revenue, primary fiscal balance, domestic debt, external debt, oil tax revenue, and non-oil tax revenue) exert significant impacts on output growth and most of the empirical results obtained support the hypothesised relationships between public finance instruments and output growth in Nigeria. However, aggregate federal government expenditure exerts a significant negative impact on output growth, while on the disaggregated scale, capital expenditure exerts a significant positive influence on output growth whereas recurrent expenditure exerts a significant negative impact on output growth. Given these findings, we recommend that the government of Nigeria, through its fiscal authorities, should adopt growth-enhancing fiscal policies that would engender macroeconomic stability and will be potent in refocusing recurrent expenditure towards ensuring productivity growth.
Institutional systems and quality of life in Sub-Saharan Africa
Authors: Awe Peter Tobi , Abdulrahman Abdulganiyu Idris
Published: May 2024

This study examined the impact of institutional systems drawn from economic and political institutions on the quality of life in Sub-Saharan Africa. A panel data of thirty-seven Sub-Saharan African countries over the period 2007 to 2021 sourced from the World Bank database and Heritage Foundation. A two-step system-Generalised Method of Movement (GMM) technique was employed to estimate the model. The Sargan test for over-identification restriction and the Arellano-Bond test for second-order serial correlation were conducted. The study reveals that there is a positive relationship between the institutional systems and the quality of life in Sub-Saharan Africa. The study concluded that, for the quality of life in Sub-Saharan Africa to improve, the government in Sub-Saharan Africa should implement laws and policies that will strengthen the existing institutions to improve the quality of life of the people.
Mainstreaming distributive justice into resources management in Nigeria: The extent of the Petroleum Industry Act 2021
Authors: San Uche Val Obi
Published: May 2024

The distribution of petroleum resources has always been an issue of serious controversy in the Nigerian state under the previous petroleum regime. Thus, this paper examined the extent to which the newly enacted Petroleum Industry Act (PIA) 2021 has engrained distributive justice with respect to petroleum resources management. It concludes that the PIA has made giant strides towards this end, in view of the creation of the Host Communities Development Trust Fund, Frontier Basin Exploration Fund and improved environment protection measures. However, this study identified certain factors which will limit the full realisation of the distributive justice intendment of the Act. It is, therefore, submitted that until these issues are addressed, distributive justice would continue to remain elusive for petroleum resources management
Strategic plans to support action against climate change in the Arab countries in the Middle East Region
Authors: Danish Mohammad , Isaifan Rima J.
Published: May 2024

Climate change has become a global challenge due to its critical impact on the natural as well as the human environment. This article focuses on the effects of climate change in the Middle East (ME) region and the strategies suggested to combat its impacts. The research involves reviewing and analyzing published articles from major databases in this domain. The literature shows that countries in the ME region, with a particular focus on the Arab countries, have also realized that urgent actions should be taken to decrease climate change threats. Several countries are committing to international principles, supporting the global effort against climate change, such as adopting renewable sources for efficient energy production. Moreover, some of the ME region countries are considered a hub for emitting CO2 because of their hot climate, which requires the use of energy for air-conditioning, high-water desalination demands due to water scarcity, and the dependence on energy-exhaustive industries. Recently, Saudi Arabia, Qatar, and the United Arab Emirates have proposed strict measures to reduce their energy consumption and move towards renewable energy sources like solar and wind energy. Some countries have also funded projects for developing green buildings to create a sustainable environment. However, this paper emphasizes the need to establish strict regulations to impose policies and practices to achieve the global temperature rise limit below 1.5oC. Moreover, all ME countries must invest in renewable energy sources by promoting education, research, and implementing carbon pricing mechanisms. Nevertheless, as part of the Paris Agreement and other international commitments, there is a growing need to develop more socio-economic policies to meet this vision.
Mineral extraction and governance in the Nigerian Mining Industry: An examination of regulatory conflicts amongst Nigeria’s three tiers of government
Authors: Omoijuanfo Ihase S. O. , Omoijuanfo Ihase S. O. , Ukponu Michael U. , Opafunso Zacheus O.
Published: May 2024

Nigeria’s abundant mineral potentials can be harnessed to significantly contribute to her socio-economic development if the regulatory framework of the Nigerian Mining Industry (NMI) is properly articulated and implemented, devoid of the regulatory conflicts that have been observed amongst various regulatory and government entities. This article analyses a 2019 – 2020 study undertaken by the Ministry of Mines and Steel development in the Federal Capital Territory and 17 out of the 36 States of the Federal Republic of Nigeria which exposed mining sector-related regulatory conflicts amongst the Federal, State and Local Governments and their Ministries, Departments, and Agencies (MDAs). The study also revealed that, despite certain extant Constitutional and statutory instruments vesting the control of minerals and mining activities on the Federal Government and its Ministry of Mines and Steel Development, the implementation of other national and subnational statutory instruments has generated regulatory conflicts and controversial interferences in the governance of mineral resources in the country. This development has led to adverse political and socio-economic implications and outcomes. Thus, after an in-depth consideration of these regulatory conflicts and its implications, the article recommends, among other salient solutions, the amendment and/or repeal of all applicable mining statutes and regulations to remove these regulatory conflicts, and this will better position the NMI on the path to restoration and ultimately surpassing its glorious past.
Perceived inadequate welfare of healthcare professionals in Nigeria and its influence on service delivery and patients’ safety
Authors: Nwafor Nneka F. , Okoye Uzoma O.
Published: May 2024

This qualitative study examines the perceived inadequate welfare of healthcare professionals in Nigeria and its influence on service delivery and patient wellbeing, focusing on Enugu State. Three research questions were formulated to guide the study. Data were collected from 12 respondents through oral interviews. The health professionals and patients of three government-owned hospitals in Nsukka LGA formed the study population, where 12 respondents were sampled using purposive and availability sampling techniques. The collected data were analysed thematically. According to the analysis, the welfare of healthcare workers in Nigeria is inadequate. This has a far-reaching impact on the quality of healthcare service delivery and patient’s well-being. The study strongly advocates the need for governmental intervention and collaboration among healthcare professionals to improve working conditions. This study also accentuates the role of social workers in advocating for better healthcare systems and patient safety.
Recruitment Advertisement and Selection Decisions in Nigerian Filling Stations
Authors: Ujebe Nome , Echezona Ovute Francis , Ogbonnia Chukwu-Etu
Published: May 2024

This study on Recruitment Advertisement and Selection Decision in Filling stations was conducted specifically to ascertain the degree external recruitment advertisement affect selection decision; to determine the degree internal recruitment advertisement affect selection  decision; and to discover the extent informal recruitment advertisement affect selection decision in Nigerian filling stations. A descriptive research design was adopted. The Resource-Based theory propounded by Barney (1986b) was also adopted for the study.  Sixty five (65) respondents being management staff of Petroleum Filling stations responded to fifteen (15) questions. The hypotheses  were tested using Regression analysis to determine the extent recruitment advertisement affect selection decision. The result showed  that informal recruitment method is most effective in selecting the right workers for the right job. Therefore, the researcher  recommended the use of informal recruitment method especially for vacancies required to be filled at short notice. He went further to  recommend the use of external recruitment method using digital platform for vacancies that would need to be filled in a longer time.  Also internal recruitment such as promotion and job rotation was recommended for adoption but that extensive use of internal  recruitment may imply that fresh candidates with new knowledge will not be opportune to work in the organization.
COVID-19 and cardiac complications: Myocarditis and multisystem inflammatory syndrome in children
Authors: Güneş Muhammed , Özdemir Öner
Published: May 2024

Coronavirus is an important pathogen causing disease in humans and animals. At the end of 2019, an investigation into an increase in pneumonia cases in Wuhan, Hubei Province, China, found that the cause was a new coronavirus. This disease, which spread rapidly across China and caused an outbreak worldwide, resulted in a pandemic. Although this virus has previously been referred to as 2019-nCoV, which causes coronavirus disease 2019 (COVID-19), later it was named severe acute respiratory syndrome coronavirus 2. Children were usually asymptomatic and rarely severely affected. In April 2020, reports from the United Kingdom indicated that children may have Kawasaki disease or a clinical condition similar to toxic shock syndrome. This clinical picture was later defined as multisystem inflammatory syndrome in children. Since then, similarly affected children as well as cases with other cardiac complications have been reported in other parts of the world. In this review, we aimed to evaluate COVID-19 in terms of cardiac involvement by reviewing the literature.
Ibrutinib and atrial fibrillation: An in-depth review of clinical implications and management strategies
Authors: Mohyeldin Moiud , Shrivastava Shitij , Allu Sai Vishnu Vardhan
Published: May 2024

Ibrutinib, a targeted therapy for B-cell malignancies, has shown remarkable efficacy in treating various hematologic cancers. However, its clinical use has raised concerns regarding cardiovascular complications, notably atrial fibrillation (AF). This comprehensive review critically evaluates the association between ibrutinib and AF by examining incidence, risk factors, mechanistic links, and management strategies. Through an extensive analysis of original research articles, this review elucidates the complex interplay between ibrutinib’s therapeutic benefits and cardiovascular risks. Moreover, it highlights the need for personalized treatment approaches, vigilant monitoring, and interdisciplinary collaboration to optimize patient outcomes and safety in the context of ibrutinib therapy. The review provides a valuable resource for healthcare professionals aiming to navigate the intricacies of ibrutinib’s therapeutic landscape while prioritizing patient well-being.
Evaluation of mitral chordae tendineae length using four-dimensional computed tomography
Authors: Mori Takuya , Matsushita Satoshi , Morita Terumasa , Abudurezake Abulaiti , Mochizuki Junji , Amano Atsushi
Published: May 2024

BACKGROUND

Mitral valvuloplasty using artificial chordae tendineae represents an effective surgical approach for treating mitral regurgitation. Achieving precise measurements of artificial chordae tendineae length (CL) is an important factor in the procedure; however, no objective index currently exists to facilitate this measurement. Therefore, preoperative assessment of CL is critical for surgical planning and support. Four-dimensional x-ray micro-computed tomography (4D-CT) may be useful for accurate CL measurement considering that it allows for dynamic three-dimensional (3D) evaluation compared to that with transthoracic echocardiography, a conventional inspection method.

AIM

To investigate the behavior and length of mitral chordae tendineae during systole using 4D-CT.

METHODS

Eleven adults aged > 70 years without mitral valve disease were evaluated. A 64-slice CT scanner was used to capture 20 phases in the cardiac cycle in electrocardiographic synchronization. The length of the primary chordae tendineae was measured from early systole to early diastole using the 3D image. The primary chordae tendineae originating from the anterior papillary muscle and attached to the A1-2 region and those from the posterior papillary muscle and attached to the A2-3 region were designated as cA and cP, respectively. The behavior and maximum lengths [cA (ma), cP (max)] were compared, and the correlation with body surface area (BSA) was evaluated.

RESULTS

In all cases, the mitral anterior leaflet chordae tendineae could be measured. In most cases, the cA and cP chordae tendineae could be measured visually. The mean cA (max) and cP (max) were 20.2 mm ± 1.95 mm and 23.5 mm ± 4.06 mm, respectively. cP (max) was significantly longer. The correlation coefficients (r) with BSA were 0.60 and 0.78 for cA (max) and cP (max), respectively. Both cA and cP exhibited constant variation in CL during systole, with a maximum 1.16-fold increase in cA and a 1.23-fold increase in cP from early to mid-systole. For cP, CL reached a plateau at 15% and remained elongated until end-systole, whereas for cA, after peaking at 15%, CL shortened slightly and then moved toward its peak again as end-systole approached.

CONCLUSION

The study suggests that 4D-CT is a valuable tool for accurate measurement of both the length and behavior of chordae tendineae within the anterior leaflet of the mitral valve.
MODUL TEKNIK PENDEKATAN RASIONAL EMOTIF TINGKAH LAKU INTEGRASI SPIRITUAL (MREBTIS) MERAWAT KEBIMBANGAN PELAJAR
Authors: MOHAMMAD ZAIN SITI ROSLINA , MOHD DAGANG MAZIDAH , RAJA IBRAHIM AJA ZIRWATUL AIDA
Published: May 2024

Modul Pendekatan Rasional Emotif Tingkah Laku (MREBTIS) telah dibina berpandukan Model Pembinaan Modul Sidek yang mengandungi dua peringkat iaitu peringkat menyediakan draf modul dan peringkat mencuba serta menilai modul. Seramai empat orang pakar penilai bidang telah dilantik bagi mengukur nilai kesahan kandungan MREBTIS dan seramai 30 orang pelajar tingkatan 4 Maktab Rendah Sains MARA (MRSM) di negeri Terengganu telah dipilih bagi mengukur nilai kebolehpercayaan modul. MREBTIS mengandungi sembilan submodul berasaskan Pendekatan Rasional Emotif Tingkah Laku oleh Albert Ellis (1955) yang diintegrasikan dengan elemen agama berpaksikan al-Quran, al-Sunnah, dan amalan ulama silam. Dapatan kajian menunjukkan bahawa MREBTIS yang dibina mempunyai nilai kesahan kandungan dan kebolehpercayaan yang baik. Kesimpulannya, MREBTIS boleh digunakan sebagai modul bagi mengurus kebimbangan dalam kalangan pelajar MRSM. Kajian ini turut menyumbang kepada perkembangan ilmu perkhidmatan bimbingan dan kaunseling berintegrasikan spiritual dan agama.
A Study on the Accumulation and Dissemination of Medical Knowledge by Literati(士大夫) in the Song Period, with a Focus on Case of Abscess(癰疽)
Authors:   Institute for Historical Studies at Chung-Ang University, Choi Hae-Byoul
Published: May 2024

In the Chinese medical history, the literati officials of the Song period
(960-1279) played a crucial role in the enormous accumulation and
dissemination of medical knowledge. More specifically, they compiled
and wrote medical books and thereby contributed to the collection and
spread of medical knowledge. It is noteworthy that they noted abscess
(癰疽), which belongs to the discipline of surgery, as a single disease
in addition to Shanghan(傷寒). Previous studies have not examined this
topic sufficiently. Most studies focused on the overall interest in
medicine by literati officials during the Song period or Shanghan or
some specific diseases endemic to the southern region. This study
focuses on activities of the literati officials during the Song period for
the accumulation and dissemination of knowledge about abscess. A
previous study noted that literati officials during the Song period had
an influence on the development of a scholarly, pulse check-based
internal medicine, and this trend continued into the Ming and Qing. This
study examines the way the literati officials of the Song period
communicated with each other in the discipline of surgery, the efforts
they made to treat abscess, and the way they interacted with local
doctors specializing in abscess, and thereby elucidates diverse aspects of a medical culture during the Song period.
Сучасна Угорщина – шлях від демократії до авторатиризму: історична ретроспектива
Authors: Ткач Д.І.
Published: May 2024

У кінці 1980-х рр., внаслідок оксамитових революцій, політичні системи більшості країн Центральної та Східної Європи (ЦСЄ) пройшли значні зміни. Цей процес також зачіпив Угорську Республіку, де зміна суспільного устрою пройшла інтенсивніше і успішніше, ніж у багатьох інших країнах ЦСЄ.
Угорщина, завдяки цим процесам, відзначилася як лідер серед країн ЦСЄ, які досягли значних досягнень у сфері політичної та економічної трансформації. Політична система суспільства зазнала значних змін. Однопартійний режим було замінено плюралістичною політичною системою, яка базувалася на Конституції, зміненій у 1989 р. Була впроваджена парламентсько-президентська система влади, яка надала уряду широкі повноваження і зобов’язала його забезпечувати умови для економічного і демократичного розвитку країни. Також була проведена реформа судової системи, і створений Конституційний Суд.
З 1990 року до 2010 року відбулася значна лібералізація суспільства, але досягнення цих років мали суперечливий та неоднозначний характер. Комерціалізація всіх сфер життя суттєво змінила загальнокультурний контекст, призвела до нових напруженостей у відносинах між різними соціальними групами і різними поколіннями, і певною мірою загострила проблему міжнаціональних відносин.
Все змінилося в 2010 р., коли на виборах в Державні збори до влади прийшла коаліція ФІДЕС-УГП-ХДНП, отримавши конституційну більшість голосів. Ця правоконсервативна коаліція успішно впроваджувала консервативну ідеологію, вміло маніпулювала громадською свідомістю, здійснювала ефективні економічні реформи, посилювала державне управління та реформувала державний сектор, спрямовуючи його к централізації і відновленню консервативних традицій угорської держави. Це також супроводжувалося згортанням демократичних принципів правління та посиленням авторитарних тенденцій.
Внаслідок цих дій, правоконсервативна коаліція зуміла перемогти на виборах до Державних зборів у 2014, 2018 та 2022 роках. Це призвело до того, що багатопартійна система, створена як противага однопартійному тоталітарному режиму, стала двополюсною з домінуючою роллю коаліції ФІДЕС-УГП-ХДНП.
Таким чином країна із усталеними демократичними традиціями перетворилася на державу з авторитарним урядом на чолі із прем’єр-міністром В.Орбаном, якого багато хто в ЄС називає диктатором.
Improved breeding and seed production of climbing perch (Anabas testudineus) in controlled tanks and cage systems
Authors: Choresca Casiano H. , Taberna Princess P. , Pedroso Fiona L. , Magbanua Faith Loraine T. , Oclos Maria Theresa T. , Danting Ma. Jodecel C.
Published: May 2024

The climbing perch (Anabas testudineus) is a valuable fish species with significant potential for aquaculture. However, a low survival rate was observed at its early development stages, requiring an optimized protocol for sustainable aquaculture production. This paper presents an improved breeding and seed production technology for climbing perch. Mature climbing perch were induced to spawn using salmon gonadotropin-releasing hormone analog (sGnRHa) at a dose of 30 µg/kg-1 body weight of the breeder. The female broodfish spawn 9–10 hours after hormone injection. Developmental stages were defined based on the morphological features of the embryos from the first cleavage to the hatching stage. The first cleavage began at approximately 18–20 minutes after fertilization. Newly hatched larvae were observed within 18–20 h at 30°C, having an average larval size of 0.389±0.042 mm (total length). Successful breeding entails a selection of suitable algal species, an optimal aquaculture environment, regular feeding rates, consistent monitoring of larval development, and effective management of water quality. Survival rates from the larval stage to fry were achieved at 84.69% and 77.60%, respectively, while the survival rate to the fingerlings stage was 72.51%. Therefore, by implementing an optimized protocol, aquaculture practitioners can maximize the production potential of climbing perch while ensuring sustainable cultivation practices. The findings from this research contribute to the advancement of climbing perch aquaculture by providing valuable insights for the successful cultivation and increased economic profitability of A. testudineus species in hatchery productions.
EVALUACIÓN DE LA CALIDAD DEL AGUA DEL RÍO CHAMBO EN ÉPOCA DE ESTIAJE UTILIZANDO EL ÍNDICE DE CALIDAD DEL AGUA ICA-NSF
Authors: Freire Rosario del Pilar , Pino-Vallejo Marco , Andrade Patricia , Mejía Ana
Published: May 2024

El deterioro de las fuentes hídricas en el Ecuador es un problema ambiental producto principalmente de las descargas de aguas residuales. A este tipo de contaminación hídrica se lo relaciona con el deterioro de los ecosistemas, pero el tema también es de salubridad. Las altas concentraciones de material orgánico e inorgánico disuelto enlos caudales de los ríos y suuso enel regadío de cultivos y abrevaderos ponen enriesgo la salud humana. En el cantón Chambo-Ecuador (altura 2780 m), el 12,95 % de la superficie total es tierra agrícola y su fuente de regadío es el río Chambo. La red de alcantarillado de este cantón descarga sus aguas residuales al río sin previo tratamiento. Para determinar las condiciones del agua de este río, se utilizó el Índice de Calidad de Agua ICA NSF. Se realizaron análisis de laboratorio fisicoquímico y microbiológico del agua del río, antes y después de las descargas de agua residual. La investigación se efectuó en época de estiaje para conocer la calidad del agua cuando existe menor capacidad de autodepuración. Los resultados de laboratorio y la ponderación con el método ICA NSF, determinaron que el agua del río Chambo es de mala calidad incluso antes de ser contaminadas con aguas residuales con un índice de calidad de 45,40% determinándose que el agua del río no es apta para ser utilizada para el riego de cultivos.
Impact of Project Planning, Monitoring And Evaluation on the Sustainability of the Millennium Village Project in Pampaida, Ikara Local Government Area of Kaduna State Nigeria
Authors:   Social Policy Specialist, UNICEF Bauchi Field Office, Bauchi State, Nigeria., Yusuf Auta , Dankumo Ali Madina ,   Dept. of Economics and Dev’t Studies, Federal University of Kashere, Gombe, Odoh Adejoh ,   Dept of Local Government and Development Studies, ABU Zaria, Marcus Nathan ,   Kaduna State College of Education, Gidan Waya
Published: May 2024

The sustainability of a project refers to the capability of a project to retain its usage over the long term. The Millennium Village Project (MVP) in Pampaida was purposely initiated to alleviate over 70% of the populace from poverty. The study examined how project planning, monitoring and evaluation influenced its sustainability, adopting the participatory and the stakeholders’ theory with the involvement of donors, government, and the community people in achieving the set goals and objectives of the Project – poverty reduction. The study applied the mixed method research technique –qualitative leading and corroborated by quantitative. We selected 368 people from the community as respondents from the 28 settlements of Pampaida to provide us with the data through structured questionnaires, interviews, focused group discussions and systematic observations. The statistical tools used in the analysis were; simple percentages, frequency tables, mean, standard deviation, and the application of the SPSS version 26 for inferential statistics while using Linear Regression Technique to test the hypothesis. In the research, hypotheses were framed in null forms to address the objectives of the study and were tested statistically, which corroborated the use of thematic analysis of interviews and observations of the research. The study found that project planning, monitoring and evaluation were significant factors that positively affect the sustainability of MVP projects. Therefore, the study recommends that; the government prioritize effective, structured and comprehensive project planning to guide the project objectives. In terms of Project execution maintenance and support, feedback mechanism and capacity-building initiative, the community needs to establish committees to implement a robust and rigorous monitoring and evaluation system.
Spatial Temporal Analysis of Air Quality and their Relation to Meteorological Parameters, in India
Authors: Suman Dash  , Aniruddha Jena
Published: May 2024

Air pollution has become a significant global issue, with India ranking 8th in the world for hazardous air quality based on the latest 2022 report. (World Air Quality Report 2023). The growing urban sprawl and human-induced environmental activities have led to a decline in air quality. The Air Quality Index assesses the level of pollution in the air at a particular region. It is a fundamental right for individuals to be informed about the quality of the air they breathe for their well-being. This study aims to examine air pollution levels and trends across various geographical locations in India using data provided by the Central Pollution Control Board under the Ministry of Environment, Forest, and Climate Change in India. The study focuses on analyzing the annual growth of pollutants such as SO2, NO2, PM10, and PM2.5 from 2016 to 2021, collected from monitoring stations in 28 states across 256 locations. The research evaluates the impact of different particulate matter concentrations and showcases the spatial variation of air pollutants between 2016 and 2021. Results indicate a significant decrease in air pollution levels during lockdown periods compared to pre-lockdown periods. On an average (over all cities), more than 24% decrease has been observed for all the AQI of the pollutants. Additionally, a comparative analysis reveals correlations between meteorological factors and air quality, showing that temperature, relative humidity, and wind speed are negatively correlated with AQI, while surface pressure is positively correlated. Temporal analysis was also conducted to examine the relationship between air pollutant concentrations and meteorological parameters.
Application of Kweau Accounting in Weddings of the Lani Tribe of Wamena Papua
Authors: Degei Yoni , Rusmita Sari , Yunita Khristina
Published: May 2024

Recording transactions for purchasing pig livestock assets as a marriage medium for the Lani tribal community in Wamena. These documents or records of transactions or events are the guidance of both parties in the marriage process. The aim of this research is to discuss identifying, measuring, communicating, presenting and disclosing kweau accounting in the marriage process of the Lani Wamena tribal community. This research used qualitative methods from the results of interviews and observations. The researcher concluded that the identification of notes needs to be adjusted to the fair value or transaction price when pig assets are purchased on the market, so that the process of measuring, communicating, presenting and disclosing in accounting is realized. The researcher also provides an overview of purchase measurement records, general journals and presentation of accounting financial reports so that they can be used at subsequent wedding events.
Peculiarities of the development and reproduction of the Russian lead and zinc mineral resource base and its forecasting for up to 2040
Authors: ALEKSEEV Yaroslav , KORCHAGINA Daria , KULIKOV Danila , NAUMOV Eugene , KONKIN VICTOR , MIGACHEV Igor , DONETS ALEXANDER , BARYSHEV ALEXANDER
Published: May 2024

The state and structure of reproduction of the lead and zinc mineral resource base are shown for the period of 1993-2022, and a forecast of its development for up to 2040 is presented. The mineral reserves movement and redemption were analyzed with account made for the mineral deposit types. The risks and limitations were identified that affected the mineral resource base sustainability. The need is justified to increase the early phase geological exploration at the expense of the federal budget funds to prepare the forecasted resources and to create an “exploration reserve” for lead and zinc.
Moderating Role of Board Independence on the Effect of Environmental and Governance Sustainability Disclosure on Firm Value of Listed Non-Financial Firms in Nigeria
Authors: Akintunde OGUNSOLA E. , DANIEL Emmanuel Kayode , Benshima ORBUNDE
Published: May 2024

A corporation’s worth may draw the attention of a variety of stakeholders, and preserving its long-term survival requires overcoming multiple hurdles, most notably the implementation of robust disclosures about environmental and governance sustainability. This study looked at how Board independence affected the link between environmental and governance sustainability disclosures and the total value of Nigerian listed non-financial firms over a decade (2012-2021). Using purposive selection, 69 firms were chosen from a population of 104 to use in a longitudinal study design. Data from the company’s annual reports were evaluated using regression analysis. The Governance Disclosure Index (GDI) and the Environmental Disclosure Index (EDI) were used as proxies for disclosures on governance and environmental sustainability, respectively, while Tobin’s Q was used to represent corporate value. The findings revealed that environmental sustainability disclosure, particularly when moderated by board independence, significantly influenced the firm value of Nigerian listed non-financial companies, whereas governance sustainability disclosure had a significant impact on firm value on its own. As a result, the research recommends that businesses encourage more sustainability transparency via rating and evaluation methods. Furthermore, they should be proactive in developing and executing governance and environmentally friendly policies and programs, since these efforts are critical to increasing their total worth.