bluuebunny/crossref_metadata_2025 huggingface dataset:
A Pilot Study of the Waterless Empirical Taste Test
Authors: Jiang Rong-San , Liu Shih-An , Wang Ching-Ping , Wu Shang-Heng , Wang Jing-Jie
Published: November 2020

Objectives:

This study was performed to test the clinical applicability of a new taste test—the waterless empirical taste test (WETT).

Methods:

Sixty healthy volunteers and 20 patients with oral cancer were enrolled. They all received the conventional solution-based whole-mouth suprathreshold taste test (WMTT), which contained sucrose, citric acid, sodium chloride, and caffeine solutions for tastants, along with the WETT. The WETT used plastic strips to deliver tastants. The strip was embedded with sucrose, citric acid, sodium chloride, caffeine, or monosodium glutamate taste enhancer in 4 different concentrations. Each strip was tested twice. Thirty of the healthy volunteers received the WETT again to measure a retest reliability. Case–control matching by age and gender was used to compare the scores of WMTT and WETT between 13 healthy volunteers and 13 patients with oral cancer.

Results:

The correlation was not high between the WMTT and WETT ( r < 0.7) whether in the healthy volunteers or in patients with oral cancer. In terms of retest reliability of the WETT, the mean total score was 24.9 ± 7.3 for the first test and 25.8 ± 8.4 for the second test. The intraclass correlation coefficient was 0.85 ( P < .001). When case–control matching was performed, the WMTT scores were not significantly different between 13 healthy volunteers and 13 patients with oral cancer ( P = .266), but the WETT scores were significantly lower in patients with oral cancer ( P = .017).

Conclusion:

This study showed that the results of the WETT were not highly correlated with those of the WMTT. However, its retest reliability was high, and its results were significantly different between the healthy volunteers and the patients with oral cancer.
Operational radiation protection for human space flight: the flight surgeon’s perspective
Authors: Straube U.
Published: November 2020

Yuri Gagarin was the first human in space in 1961 almost 60 years ago. Eight years later Neil Armstrong left his footprints on the Moon – the first human on the surface of a celestial body other than Earth. By now long-duration missions of up to 1 year have become a reality for humans in space. Nearly 19 years of continuous human presence at the International Space Station (ISS) have provided a unique insight into human life in space. Humans are reaching out for more – targeting missions to take us outside the protective hull of low earth orbit into deep space. The challenges to human health and well-being remain significant and increase with distance and time from Earth. The lack of gravity, the ubiquitous ionising radiation, remoteness, and confinement are just some examples of the hostile environment of space. More hurdles have to be overcome prior to the human endeavour of reaching out into deep space and radiation is one such primary and inevitable factor that is key to crew health, safety and overall mission success. This presentation will provide an introduction into operational space medicine and radiation protection for humans in space as executed on ISS, in low earth orbit and in preparation for the scenarios ‘beyond’.
Diversity and data: an ontology of race and ethnicity in the British Film Institute’s Diversity Standards
Authors: Nwonka Clive James
Published: November 2020

This article addresses the role of data in the analysis of racial diversity in the UK film industry. Due to the prolonged poor representation of racial difference, academic researchers increasingly identify the UK film sector as a particular site of multi-dimensional structural inequalities. This article will assess the impact of data-led interventions made by the UK film industry to increase the presence of BAME individuals within the sector. It will do this through an analysis of the policy approach of the UK’s lead body for film, the British Film Institute, examining how one major policy initiative, the BFI’s Diversity Standards launched in 2016 as an industry intervention into prevailing sector inequalities, has sought to achieve racial diversity and inclusion across its Film Fund-supported film productions between 2016 and 2019. Analysing cross-sectional data from 235 films which is aggregated across differing film genres, budgets and regions, the study assesses how the outcomes of the Diversity Standards have offered a representation of racial diversity across these production areas.
Comprehensive Treatment Strategy for Internal Carotid Artery Blowout Syndrome Caused by Nasopharyngeal Carcinoma
Authors: Zhao Zhouyang , Huang Lijin , Chen Jinhua , Huang Weijia , Zhang Xiaobin , Ma Yue , Zhu Hongshen , Liu Zhang
Published: November 2020

Objective

To evaluate a treatment strategy for internal carotid artery blowout syndrome caused by nasopharyngeal carcinoma.

Study Design

A retrospective analysis of a case series was performed.

Setting

Carotid blowout syndrome is a catastrophic complication caused by malignant tumor of the skull base.

Methods

A retrospective analysis based on 69 patients with internal carotid artery blowout syndrome admitted to our center between April 2018 and January 2020 was performed. The patients were divided into 2 groups: an EBBA (internal carotid artery embolization + bypass based on American Society of Intervention and Therapeutic Neuroradiology/Society of Interventional Radiology [ASITN/SIR]) group and an embolization/stent group. The follow‐up time was 6 to 9 months.

Results

In the EBBA group, 41 patients (41/49, 83.7%) survived. Forty patients had a satisfactory quality of life after 3 months. No death occurred within 3 months. Nonoperative death occurred in 8 cases (8/49, 16.3%). The rate of mortality and disability was 18.4% (9/49). In the embolization/stent group, 16 patients (16/20, 80%) survived. Nonoperative death occurred in 4 cases (4/20, 20%), 3 of which occurred within 1 to 3 months. Four cases reported Modified Rankin Scale ≥2 after 3 months. The rate of mortality and disability was 40% (8/20).

Conclusion

A comprehensive revascularization strategy for internal carotid artery (ICA) embolization and intracranial and extracranial bypass grafting based on ASITN/SIR score for ICA blowout syndrome patients not only can prolong the patient survival but also greatly improve the survival probability and quality of life as well as reduce their rate of mortality or disability.
Does Ibuprofen Increase Bleed Risk for Pediatric Tonsillectomy?
Authors: Leung Peggy , DeVore Elliana Kirsh , Kawai Kosuke , Yuen Sonia , Kenna Margaret , Irace Alexandria L. , Roberson David , Adil Eelam
Published: November 2020

Objective

To evaluate risk factors for pediatric posttonsillectomy hemorrhage (PTH) and the need for transfusion using a national database.

Study Design

Retrospective cohort study.

Setting

The study was conducted using the Pediatric Health Information System (PHIS) database.

Methods

Children ≤18 years who underwent tonsillectomy with or without adenoidectomy (T±A) between 2004 and 2015 were included. We evaluated the risk of PTH requiring cauterization according to patient demographics, comorbidities, indication for surgery, medications, year of surgery, and geographic region.

Results

Of the 551,137 PHIS patients who underwent T±A, 8735 patients (1.58%) experienced a PTH. The risk of PTH increased from 1.33% (95% confidence interval [CI]: 1.15%, 1.53%) in 2010 to 1.91% (95% CI: 1.64%, 2.24%) in 2015 (P <. 001). Older age (≥12 vs <5 years old: adjusted odds ratio [aOR] 3.17; 95% CI: 2.86, 3.52), male sex (aOR 1.11; 95% CI: 1.05, 1.17), medical comorbidities (aOR 1.18; 95% CI: 1.08, 1.29), recurrent tonsillitis (aOR 1.15; 95% CI: 1.07, 1.24), and intensive care unit admission (aOR 1.74; 95% CI: 1.55, 1.95) were significantly associated with an increased risk of PTH. Use of ibuprofen (aOR 1.36; 95% CI: 1.22, 1.52), ketorolac (aOR 1.39; 95% CI: 1.14, 1.69), anticonvulsant (aOR 1.23; 95% CI: 1.03, 1.76), and antidepressants (aOR 1.35; 95% CI: 1.03, 1.76) were also associated with an increased risk of PTH. The need for blood transfusion was 2.1% (181/8735).

Conclusion

The incidence of PTH increased significantly between 2011 and 2015, and ibuprofen appears to be one contributing factor. Given the benefits of ibuprofen, it is unclear whether this increased risk warrants a change in practice.
Medical Student Participation in Otolaryngology Telemedicine Clinic During COVID‐19: A Hidden Opportunity
Authors: Pellegrini William R. , Danis David O’Neil , Levi Jessica R.
Published: November 2020

The undergraduate medical student educational experience was greatly altered this year due to coronavirus disease 2019. Many otolaryngology departments increased use of telemedicine technologies to avoid the need for in‐person contact. Medical student incorporation into telemedicine clinics is important to increase their comfort with this format of patient care and to continue student exposure to the field of otolaryngology. The technical and logistical aspects of student inclusion in telemedicine clinics at our institution are detailed. While telemedicine is still an evolving tool for experienced practitioners, there are likely advantages to the use of telemedicine patient visits for student learning. These may include closer working relationships between student and preceptor, as well as increased opportunities for student observation and feedback. Medical students should not assume telemedicine experiences are of inferior educational quality to in‐person patient interactions. Future research should investigate ways telemedicine could enhance student learning.
Association of maternal food insecurity before and during pregnancy with fetal structural anomalies: A multicenter case-control study protocol
Authors: Zaçe Drieda , Hoxhaj Ilda , Pasciuto Tina , D’Anna Rosario , Straface Gianluca , Reali Laura , De Santis Marco , Di Pietro Maria Luisa
Published: November 2020

Background:

Food insecurity, an issue also affecting developed countries, is associated with different negative outcomes. Particularly in pregnant women, a vulnerable population group, it has a double burden, as it affects both the woman and her child. Food insecurity has been associated with low birth weight and shorter gestational age, but there is less evidence on the association with fetal structural anomalies.

Aim:

To fill this gap, a study will be conducted to examine if pregnant women in a condition of food insecurity have a higher risk for fetal structural anomalies.

Methods:

A case-control study will be conducted in three centers. Cases will be pregnant women (>18 years old) diagnosed with a fetal structural anomaly during the prenatal ultrasound examination of the II–III trimester, while controls will be pregnant women (>18 years old) with a negative result for fetal structural anomaly at the II–III trimester prenatal ultrasound examination. The exposure of interest will be food insecurity during the last 12 months, measured using the validated Household Food Insecurity Access Scale. A dedicated questionnaire will be given to women after they sign the informed consent form.

Finding a positive association between food insecurity in pregnant women and fetal structural anomalies could be the first step towards screening for it among pregnant women and designing policies that could mitigate this condition. Lowering food insecurity could prevent a certain number of fetal structural anomalies, leading to fewer negative pregnancy outcomes and health problems during childhood and adulthood.
The future of rehabilitation in the United Kingdom National Health Service: Using the COVID-19 crisis to promote change, increasing efficiency and effectiveness
Authors: Wade Derick T
Published: November 2020

The problem:

Rehabilitation services in the UK are inadequate, with insufficient capacity or flexibility to meet the needs of patients after Covid-19.

History:

Rehabilitation developed in a piecemeal way, focused on specific problems: spinal cord injury, burns, polio, stroke, back pain, equipment and adaptations etc. Rehabilitation is also provided using other names (e.g. intermediate care). Patients with complex needs do not fit easily within this system.

System failure:

After Covid-19, patients have problems that cross existing condition-specific and/or treatment-specific services. Covid-19 has exposed the lack of any coherent organisational principle underlying development or commissioning of rehabilitation services. Consequently, in order to have their needs met, patients either have to engage with two or more separate services or they receive good management for some problems and sub-optimal management for other problems.

The goals:

The multitude of small specific services need to coalesce into an integrated service able to meet all the needs of any patient referred. Second, rehabilitation needs to be fully integrated into all healthcare services.

A solution:

The purpose of healthcare is to ‘ improve our health and well-being . . . to stay as well as we can to the end of our lives’. (NHS constitution) All healthcare services need to consider patients holistically, giving equal attention to disease, disability, and distress. Rehabilitation, acute care, mental health and palliative care services need to work in parallel to achieve this purpose. Healthcare providers, supported by commissioners and rehabilitation experts, could achieve structural and organisational change, meeting the needs of patients.
Stationary cycling exercise for knee osteoarthritis: A systematic review and meta-analysis
Authors: Luan Lijiang , Bousie Jaquelin , Pranata Adrian , Adams Roger , Han Jia
Published: November 2020

Objective:

To evaluate effects of stationary cycling exercise on pain, function and stiffness in individuals with knee osteoarthritis.

Data sources:

Systematic search conducted in seven databases (PubMed, Embase, Cochrane Library, Web of Science, EBSCO, PEDro, and CNKI) from inception to September 2020.

Review methods:

Included studies were randomized-controlled trials involving stationary cycling exercise conducted on individuals with knee osteoarthritis. End-trial weighted mean difference (WMD) and 95% confidence interval (CI) were analyzed, and random-effects models were used. Methodological quality and risk bias were assessed by using the Physiotherapy Evidence Database scale and Cochrane Collaboration tool, respectively.

Results:

Eleven studies with 724 participants were found, of which the final meta-analysis was performed with eight. Compared to a control (no exercise), stationary cycling exercise resulted in reduced pain (WMD 12.86, 95% CI 6.90–18.81) and improved sport performance (WMD 8.06, 95% CI 0.92–15.20); although most of the meta-analysis results were statistically significant, improvements in stiffness (WMD 11.47, 95% CI 4.69–18.25), function (WMD 8.28, 95% CI 2.44–14.11), symptoms (WMD 4.15, 95% CI −1.87 to 10.18), daily living (WMD 6.43, 95% CI 3.19 to 9.66) and quality of life (WMD 0.99, 95% CI −4.27 to 6.25) for individuals with knee osteoarthritis were not greater than the minimal clinically important difference values for each of these outcome measures.

Conclusions:

Stationary cycling exercise relieves pain and improves sport function in individuals with knee osteoarthritis, but may not be as clinically effective for improving stiffness, daily activity, and quality of life.
Utilization of Private Sector Family Planning Services in Malaysia
Authors: Lai Siow Li , Tey Nai Peng , Mahmud Adzmel , Ismail Najihah
Published: November 2020

Background

The private sector is playing an increasingly important role in family planning services globally. The active participation of private providers is associated with a higher contraceptive prevalence rate.

Objectives

To examine the differentials and determinants of the utilization of private providers for family planning services.

Method

This study used the 2014 Malaysian Population and Family Survey data. Cross-tabulations and logistic regression were performed on 1,817 current users of modern methods.

Results

Overall, 26% of modern method users obtained their supplies from private clinics/pharmacies and 15.2% from other sources, such as drug stores and sundry shops. The odds of utilizing the private sector for family planning services differ significantly across regions and socio-economic groups. The odds of obtaining supply from the private clinics/pharmacies were higher among the Chinese and urban women (AOR > 1), and it was lower among those from the eastern region (AOR = 0.47, 95% CI = 0.30–0.73). Non-Bumiputera, urban, higher educated, and working women, and those whose husbands decided on family planning had higher odds of obtaining the supply from the other sources (AOR > 1).

Conclusion

The private sector complements and supplements the public sector in providing family planning services to the public.
The Predictive Validity of Three Youth Violence Assessment Instruments: The SAVRY, VRS-YV, and SAPROF-YV
Authors: Koh Li Lian , Day Andrew , Klettke Bianca , Daffern Michael , Chu Chi Meng
Published: November 2020

This study examined the predictive validity of three assessment instruments for violent youth, the SAVRY, the VRS-YV, and the SAPROF-YV. Files relating to a sample of 233 young male offenders aged between 12 and 18 years were retrospectively reviewed to score each instrument, with reoffending data extracted from prison, community and juvenile justice records. The analysis showed that all three assessments predicted general (any) reoffending better than violent and non-violent reoffending, with higher rates of predictive validity for the SAVRY and VRS-YV Total Scores. There were, however, only small to moderate effect sizes at 1- and 3-year follow up periods for all three instruments in predicting all types of reoffending. The SAPROF-YV had a small effect size for the prediction of violent reoffending and did not add incrementally to the predictive validity (for violent reoffending) of the SAVRY or VRS-YV.
Sudden hearing loss following acute carbon monoxide poisoning: A case report and literature review
Authors: Li Chiao‐Zhu , Li Chiao‐Ching , Lin Meng‐Chi , Tseng Wei‐Shih
Published: November 2020

Introduction:

Acute carbon monoxide (CO) poisoning could lead to headache, dizziness, myocardial injury, neurological sequela, and death. Sudden hearing loss is a rare symptom of acute CO poisoning.

Case Presentation:

Here, we report a case of a 42‐year‐old woman who suffered from acute hearing loss after exposure to a suicidal environment of high concentration of CO. Partial recovery of hearing was demonstrated after a combination of corticosteroid and hyperbaric oxygen therapy was given.

Discussion:

The mechanism of sudden hearing loss caused by acute CO poisoning is not well‐established. It is believed to be related with the hypoxic damage to the cochlea. The characteristic of sudden hearing loss caused by acute CO poisoning is that it often affects in high frequency bilaterally.

Conclusion:

This report would prompt the clinician in early recognition of this sudden hearing loss of uncommon etiology.
The Hypoplasic Mandible: What Makes it Different From the Healthy Child?
Authors: Remy Floriane , Godio-Raboutet Yves , Captier Guillaume , Bonnaure Pierre , Burgart Philippe , Guyot Laurent , Thollon Lionel
Published: November 2020

Objective:

This study aimed to analyze the morphology of the hypoplasic mandible and its evolution during the growth period to better understand how it differs from the pediatric healthy mandible.

Method:

Three-dimensional mandibular models of hypoplasic and healthy children aged from 39 gestational weeks to 7 years old were analyzed with a morphometric method including data clustering. Morphological distinctions between pathological and healthy mandibles were highlighted. Bilateral and unilateral mandibular hypoplasia were distinguished.

Results:

The study sample was composed of 31 hypoplasic children and as many sex- and age-matched healthy children. Morphological distinctions between pathological and healthy mandibles were highlighted only from the first year of life. In bilateral hypoplasia, the overall mandibular dimensions were reduced while there was only a ramus asymmetry in unilateral mandibular hypoplasia (mean ± SD of the difference between the Grp03c and Grp03b subgroups: 6.80 ± 6.37 – P value = 1.64e–3 for the height of the left ramus versus 0.18 ± 4.18 – P value = .82 for the height of the right ramus). Supervised classification trees were built to identify the pathology and discriminate unilateral from bilateral mandibular hypoplasia (prediction rates = 81% and 84%, respectively).

Conclusions:

Based on a morphometric analysis, we demonstrated that mandibular hypoplasia significantly impacts the mandibular morphology only from the first year of life, with a distinction between bilateral and unilateral hypoplasia.
Taguchi optimization of various parameters for tribological performance of polyalphaolefins based nanolubricants
Authors: Kumar Homender , Harsha AP
Published: November 2020

This research paper addresses the optimization of various control parameters by using the Taguchi method to assess the tribological properties of PAOs based nanolubricants. The concentration of COOH-functionalized multiwalled carbon nanotubes (MWCNTs), applied load, sliding velocity and kinematic viscosity of polyalphaolefins (PAOs) were selected as process parameters or control factor. The MWCNTs at a varying concentration (0.025-0.15 wt.%) were blended separately in PAOs to formulate the nanolubricants. The tribological experimentations were performed by Taguchi’ L18 mixed orthogonal array using “ball on disc” type tribometer. The analysis of variance (ANOVA) was adopted to estimate the most prominent factors influencing the tribological performance of nanolubricants. The statistical results showed that the applied load, followed by a concentration of MWCNTs conferred the most significant impact on the frictional characteristic. In contrast, the kinematic viscosity of PAOs, followed by concentration of MWCNTs has been observed the most significant influencing factors on the antiwear properties of nanolubricants. The probabilistic rationale for the advancement in friction and wear properties were assessed through various analytical tools.
Managing older adults’ fear of coronavirus disease: A new role for social work practice
Authors: Mortazavi Hamed
Published: November 2020

As the number of patients infected with the 2019 novel coronavirus disease (nCOVID-19) increases, the number of deaths has also been increasing. According to World Health Organization (WHO), as of 4 October 2020, 34,804,348 cases had tested positive for nCOVID-19 globally, which among them, 1,030,738 confirmed deaths had occurred, equivalent to a case-fatality rate of 2.96%. However, in comparison with global statistics, the incidence and mortality of the nCOVID-19 infection are higher in Iran. As reported by the National Committee on COVID-19 Epidemiology of Ministry of Health of Iran, the total number of patients with confirmed COVID-19 infection has reached 468,119, of which 26,746 have died, equivalent to a case-fatality rate of 5.71%. Currently, there is solid evidence that older adults are at a higher risk of severe disease following infection from COVID-19.
A short history of thrombectomy – Procedure and success analysis of different endovascular stroke treatment techniques
Authors: Friedrich B , Boeckh-Behrens T , Krüssmann V , Mönch S , Kirschke J , Kreiser K , Berndt M , Lehm M , Wunderlich S , Zimmer C , Kaesmacher J , Maegerlein C
Published: November 2020

Background

The historical development of interventional stroke treatment shows a wide variation of different techniques and materials used. Thus, the question of the present work is whether the technical and procedural differences of thrombectomy techniques lead to different technical and clinical results.

Methods and results

Analysis of a mixed retrospective/prospective database of all endovascular treated patients with an occlusion of the Carotid-T or M1 segment of the MCA at a single comprehensive stroke center since 2008. Patients were classified regarding the technical approach used. Six hundred sixty-eight patients were available for the final analysis. Reperfusion rates ranged between 56% and 100% depending on the technical approach. The use of balloon guide catheters and most recently the establishment of combination techniques using balloon guide catheters, aspiration catheters and stent retrievers have shown a further significant increase in the rates of successful recanalization, full recanalization and first-pass recanalization. Additionally, the technical development of interventional techniques has led to a subsequent drop in complications, embolization into previously unaffected territories in particular.

Conclusion

Technical success of MT has improved substantially over the past decade owing to improved materials and procedural innovations. Combination techniques including flow modulation have emerged to be the most effective approach and should be considered as a standard of care. Level of evidence: Level 3, retrospective study.
Anterior hip ultrasound: A useful technique in developmental dysplasia of the hips
Authors: Taylor Margaret A , Maclean James GB
Published: November 2020

Introduction: Infant developmental dysplasia of the hips arises when there is an interruption to normal joint development, usually present at birth but may be a later development. It has a wide spectrum of severity with potentially disastrous long-term complications if left untreated. Incidence is highly variable, often being attributed to differences of opinion in definition and diagnosis; however, there is consensus that ultrasound be used in screening and management. Topic Description: The anterior hip ultrasound technique is underutilised but is of value due to the additional confidence it provides regarding joint stability. Discussion: The ability to relate the acquired ultrasound image to hip anatomy and a technical appreciation of the technique are crucial to successful use. The method is described and its use within previous literature briefly outlined. Using pictorial ultrasound imaging examples to demonstrate the technique, we aim to highlight the anterior approach as a useful addition to ultrasound assessment of infant developmental dysplasia of the hips. Conclusion: Knowledge and understanding of different techniques is essential for practitioners involved in the diagnosis and management of this multifaceted and vigorously debated condition.
Differences in glucose level between right arm and left arm using continuous glucose monitors
Authors: Kim Nicole , Pham Kevin , Shek Allen , Lim Jeremy , Liu Xiaohan , Shah Sachin A
Published: November 2020

Background

Continuous glucose monitoring (CGM) measures interstitial glucose levels through a sensor with a thin filament inserted under the skin. It is customary for patients to rotate sensor application sites between arms to minimize skin irritation. However, there is limited data regarding the degree of inter-arm differences with CGM technology.

Methods

Self-proclaimed right-handed (n = 5) and left-handed (n = 5) participants, regardless of concurrent comorbidities, were enrolled for CGM. Participants wore a FreeStyle Libre Pro sensor on each arm for a maximum of 14 days. Muscle mass and body fat analysis was conducted using a multi-frequency segmental body composition analyzer. Glucose levels from both arms were time-matched with the first 12 hours eliminated from analysis. Mean glucose and time in target range were compared between readings from the right and left arm.

Results

A total of 9830 paired glucose levels were included for analysis. In all participants (n = 10), mean glucose on the right arm was 89.1 mg/dL (SD, 19.9) and 85.3 mg/dL (SD, 19.3) on the left arm (P < 0.001). Glucose was out of target range (70-180 mg/dL) for 12.7% of the time in the right arm compared to 18.5% in the left arm (P < 0.001).

Conclusions

In a group of 10 nondiabetic and diabetic adults, there was a statistically significant difference in CGM readings between the right and left arms. Time in target range may differ based on arm selection when using a CGM. Arm dominance did not explain the inter-arm glucose level discordance.
A Meta-Analytic Investigation of the Relationship Between Emotional Intelligence and Emotional Manipulation
Authors: Ngoc Nguyen Nhu , Tuan Nham Phong , Takahashi Yoshi
Published: November 2020

This study examines a possible dark side of emotional intelligence (EI). Specifically, a meta-analytic investigation of 5,687 participants was conducted to examine the relationship between EI and emotional manipulation. The findings revealed that self-reported ability-based EI was positively correlated to non-prosocial emotional manipulation (as measured by the Emotional Manipulation Scale), with a 0.10 effect size. Whereas, a negative relationship emerged between self-reported trait EI and non-prosocial emotional manipulation (as measured by the Worsen factor of the Managing Emotions of Others Scale [MEOS]), with a −0.16 effect size. Moreover, self-reported trait-based EI was positively correlated with prosocial emotional manipulation (as measured by the Enhance and Divert factors of the MEOS), with effect sizes of 0.40 and 0.34, respectively. Furthermore, gender had a moderating effect on the relationship between self-reported ability-based EI and non-prosocial emotional manipulation; this relationship was stronger among males than females. We discuss the implications of these findings across academic and practice settings.
Assessing Mindfulness-Based Teaching Competence: Good Practice Guidance
Authors: Crane Rebecca , Koerbel Lynn , Sansom Sophie , Yiangou Alison
Published: November 2020

Inclusion of assessment of teaching competence in Mindfulness-Based Program (MBP) teacher training enables international benchmarking of standards, which in turn underpins the integrity of this emerging field and the potential to deliver effective, transformative interventions. However, there is a risk that the inclusion of competence assessment could lead to reductionism and undermining of the pedagogical features that make mindfulness-based teaching distinct. It can also make the costs of training prohibitive. The science underpinning the integrity of competence assessment is not yet robust enough to justify wide scale implementation, but when feasible, including the option for assessment enables trainees to engage in rigorous and effective training processes. When assessment is included, it is critically important that the process is held with awareness and sensitivity, and is implemented by experienced assessors with thoughtful governance. Navigating these issues involves balancing rigour with accessibility and pragmatism. This paper lays out some guidelines for good practice for MBP teaching assessment, and raises unresolved dilemmas and questions.
Constructions, Claims, Resonance, Reflexivity: Language and Market Categorization
Authors: Granqvist Nina , Siltaoja Marjo
Published: November 2020

Studies on market categorization exhibit substantial agreement that language plays a central role in articulating and constructing meanings among market participants and crafting consensus to produce a collective of interacting market actors. The purpose of this paper is to take stock of the growing body of research on language and market categories. This review has two aims. We begin by identifying how scholars have applied a variety of language constructs in category research, providing an understanding of the differences between these constructs and elaborating their uses and functions in the studies on market categorization. The second part of the review then provides a detailed analysis of the applications of these constructs in empirical studies addressing various situations and settings for categorization. We conclude the review by providing a synthesis of the role of language in market categorization and discuss avenues for future research.
How I diagnose and treatNPM1-mutated AML
Authors: Falini Brunangelo , Brunetti Lorenzo , Martelli Maria Paola
Published: November 2020

Mutations of the nucleophosmin (NPM1) gene, encoding for a nucleolar multifunctional protein, occur in approximately one-third of adult acute myeloid leukemia (AML). NPM1-mutated AML exhibits unique molecular, pathological, and clinical features, which led to its recognition as distinct entity in the 2017 World Health Organization (WHO) classification of myeloid neoplasms. Although WHO criteria for the diagnosis of NPM1-mutated AML are well established, its distinction from other AML entities may be difficult. Moreover, the percentage of blasts required to diagnose NPM1-mutated AML remains controversial. According to the European LeukemiaNet (ELN), determining the mutational status of NPM1 (together with FLT3) is mandatory for accurate relapse-risk assessment. NPM1 mutations are ideal targets for measurable residual disease (MRD) monitoring, since they are AML specific, frequent, very stable at relapse, and do not drive clonal hematopoiesis of undetermined significance. MRD monitoring by quantitative polymerase chain reaction of NPM1-mutant transcripts, possibly combined with ELN genetic-based risk stratification, can guide therapeutic decisions after remission. Furthermore, immunohistochemistry can be very useful in selected situations, such as diagnosis of NPM1-mutated myeloid sarcoma. Herein, we present 4 illustrative cases of NPM1-mutated AML that address important issues surrounding the biology, diagnosis, and therapy of this common form of leukemia.
Hereditary hemorrhagic telangiectasia: systemic therapies, guidelines, and an evolving standard of care
Authors: Al-Samkari Hanny
Published: November 2020

Hereditary hemorrhagic telangiectasia (HHT) management is evolving because of the emergence and development of antiangiogenic therapies to eliminate bleeding telangiectasias and achieve hemostasis. This progress is reflected in recent clinical recommendations published in the Second International Guidelines for the Diagnosis and Treatment of HHT, in which systemic therapies including antiangiogenics and antifibrinolytics are now recommended as standard treatment options for bleeding. This review highlights the new recommendations especially relevant to hematologists in managing bleeding, anticoagulation, and anemia in patients with HHT.
Combined oral 5-azacytidine and romidepsin are highly effective in patients with PTCL: a multicenter phase 2 study
Authors: Falchi Lorenzo , Ma Helen , Klein Sandra , Lue Jennifer K. , Montanari Francesca , Marchi Enrica , Deng Changchun , Kim Hye A. , Rada Aishling , Jacob Alice T. , Kinahan Cristina , Francescone Mark M. , Soderquist Craig R. , Park David C. , Bhagat Govind , Nandakumar Renu , Menezes Daniel , Scotto Luigi , Sokol Lubomir , Shustov Andrei R. , O’Connor Owen A.
Published: November 2020

Peripheral T-cell lymphomas (PTCLs) are uniquely vulnerable to epigenetic modifiers. We demonstrated in vitro synergism between histone deacetylase inhibitors and DNA methyltransferase inhibitors in preclinical models of T-cell lymphoma. In a phase 1 trial, we found oral 5-azacytidine and romidepsin to be safe and effective, with lineage-selective activity among patients with relapsed/refractory (R/R) PTCL. Patients who were treatment naïve or who had R/R PTCL received azacytidine 300 mg once per day on days 1 to 14, and romidepsin 14 mg/m2 on days 8, 15, and 22 every 35 days. The primary objective was overall response rate (ORR). Targeted next-generation sequencing was performed on tumor samples to correlate mutational profiles and response. Among 25 enrolled patients, the ORR and complete response rates were 61% and 48%, respectively. However, patients with T-follicular helper cell (tTFH) phenotype exhibited higher ORR (80%) and complete remission rate (67%). The most frequent grade 3 to 4 adverse events were thrombocytopenia (48%), neutropenia (40%), lymphopenia (32%), and anemia (16%). At a median follow-up of 13.5 months, the median progression-free survival, duration of response, and overall survival were 8.0 months, 20.3 months, and not reached, respectively. The median progression-free survival and overall survival were 8.0 months and 20.6 months, respectively, in patients with R/R disease. Patients with tTFH enjoyed a particularly long median survival (median not reached). Responders harbored a higher average number of mutations in genes involved in DNA methylation and histone deacetylation. Combined azacytidine and romidepsin are highly active in PTCL patients and could serve as a platform for novel regimens in this disease. This trial was registered at www.clinicaltrials.gov as #NCT01998035.
Estrogen receptors α, β and GPER in the CNS and trigeminal system - molecular and functional aspects
Authors: Warfvinge Karin , Krause Diana N. , Maddahi Aida , Edvinsson Jacob C. A. , Edvinsson Lars , Haanes Kristian A.
Published: November 2020

Background

Migraine occurs 2–3 times more often in females than in males and is in many females associated with the onset of menstruation. The steroid hormone, 17β-estradiol (estrogen, E2), exerts its effects by binding and activating several estrogen receptors (ERs). Calcitonin gene-related peptide (CGRP) has a strong position in migraine pathophysiology, and interaction with CGRP has resulted in several successful drugs for acute and prophylactic treatment of migraine, effective in all age groups and in both sexes.

Methods

Immunohistochemistry was used for detection and localization of proteins, release of CGRP and PACAP investigated by ELISA and myography/perfusion arteriography was performed on rat and human arterial segments.

Results

ERα was found throughout the whole brain, and in several migraine related structures. ERβ was mainly found in the hippocampus and the cerebellum. In trigeminal ganglion (TG), ERα was found in the nuclei of neurons; these neurons expressed CGRP or the CGRP receptor in the cytoplasm. G-protein ER (GPER) was observed in the cell membrane and cytoplasm in most TG neurons. We compared TG from males and females, and females expressed more ER receptors. For neuropeptide release, the only observable difference was a baseline CGRP release being higher in the pro-estrous state as compared to estrous state. In the middle cerebral artery (MCA), we observed similar dilatory ER-responses between males and females, except for vasodilatory ERβ which we observed only in female arteries.

Conclusion

These data reveal significant differences in ER receptor expression between male and female rats. This contrasts to CGRP and PACAP release where we did not observe discernable difference between the sexes. Together, this points to a hypothesis where estrogen could have a modulatory role on the trigeminal neuron function in general rather than on the acute CGRP release mechanisms and vasomotor responses.
Characterization and Fabrication of the CFM-JTE for 4H-SiC Power Device with High-Efficiency Protection and Increased JTE Dose Tolerance Window
Authors: Wen Yi , Xu Xiao-jie , Tao Meng-ling , Lu Xiao-fei , Deng Xiao-chuan , Li Xuan , Li Jun-tao , Li Zhi-qiang , Zhang Bo
Published: November 2020

A 13.5 kV 4H-SiC PiN rectifier with a considerable active area of 0.1 cm2 is fabricated in this paper. Charge-field-modulated junction termination extension (CFM-JTE) has been proposed for satisfying the requirement of ultra-high reverse voltage, which enlarges the JTE dose tolerance window, making it approximately 2.8 times that of the conventional two-zone JTE. Besides, the CFM-JTE can be implemented through the conventional two-zone JTE process. The measured forward current is up to 100 A @ VF = 5.2 V in the absence of carrier lifetime enhancement technology. The CFM-JTE structure accomplishes 96% of the theoretical breakdown voltage of the parallel plane junction with a relatively small terminal area of 400 μm, which contributes to achieving the Baliga’s figure of merit of 58.8 GW/cm2.
Mobility-as-a-service (MaaS) digital marketplace impact on EU passengers’ rights
Authors: Murati Erion
Published: November 2020

Integrated and seamless mobility has been a futuristic vision of mobility for a few years already. Today, Mobility as a Service (MaaS) embodies that vision through the integration of existing and new mobility services into one single digital platform, providing customised door-to-door transport and offering personalised trip or packages planning and payment options. The MaaS concept enable a practical shift from a fragmented and unimodal transport towards a harmonized, centralized and multimodal one, yet the current EU transport law, which is based on the principle of unimodality transport regulation, does not cover any passenger multimodal transport. Thus, as MaaS providers generate multimodal travel chains, it’s problematic that under EU law there is no harmonised legal base for multimodal passenger travel. Moreover, passenger rights cannot be guaranteed when an event occurring during one transport segment affects the following one, if the latter segment is operated with another operator of transport. In light of this, the knowledge gaps that this paper aims to fulfil are to comprehend, on the one hand, the status quo of EU passenger legislation and, on the other hand, the impact of MaaS concept on EU passenger’s rights. This will be achieved by analysing the EU transport law and its adequacy to cover passenger’s rights through a MaaS multimodal journey, as well as the position of a MaaS provider in a travel chain.
Transcriptome analysis of genes and pathways associated with metabolism in Scylla paramamosain under different light intensities during indoor overwintering
Authors: Li Na , Zhou Junming , Wang Huan , Mu Changkao , Shi Ce , Liu Lei , Wang Chunlin
Published: November 2020

Background

Scylla paramamosain is one of the commercially crucial marine crustaceans belonging to the genus Scylla, which is commonly distributed along the coasts of China, Vietnam, and Japan. Genomic and transcriptomic data are scarce for the mud crab. Light intensity is one of the ecological factors that affect S. paramamosain during indoor overwintering. To understand the energy metabolism mechanism adapted to light intensity, we analyzed the transcriptome of S. paramamosain hepatopancreas in response to different light intensities (0, 1.43, 40.31 μmol·m− 2·s− 1).

Results

A total of 5052 differentially expressed genes were identified in low light group (LL group, 3104 genes were up-regulated and 1948 genes were down-regulated). A total of 7403 differentially expressed genes were identified in high light group (HL group, 5262 genes were up-regulated and 2141 genes were down-regulated). S. paramamosain adapts to different light intensity environments through the regulation of amino acids, fatty acids, carbon and energy metabolism. Different light intensities had a strong impact on the energy generation of S. paramamosain by influencing oxygen consumption rate, aerobic respiration, glycolysis/gluconeogenesis pathway, the citrate cycle (TCA cycle) and fatty acid degradation.

Conclusion

Low light is more conducive to the survival of S. paramamosain, which needs to produce and consume relatively less energy to sustain physiological activities. In contrast, S. paramamosain produced more energy to adapt to the pressure of high light intensities. The findings of the study add to the knowledge of regulatory mechanisms related to S. paramamosain metabolism under different light intensities.
Integrated analysis of lncRNAs and mRNAs reveals key trans-target genes associated with ETEC-F4ac adhesion phenotype in porcine small intestine epithelial cells
Authors: Augustino Serafino M. A. , Xu Qinglei , Liu Xueqin , Mi Siyuan , Shi Liangyu , Liu Yibing , Wen Hui , Wang Di , Liu Lei , Zhang Qin , Yu Ying
Published: November 2020

Background

Long non-coding RNAs (lncRNAs) play crucial roles in gene regulation at the transcriptional and post-transcriptional levels. LncRNAs are belonging to a large class of transcripts with ≥200 nt in length which do not code for proteins, have been widely investigated in various physiological and pathological contexts by high-throughput sequencing techniques and bioinformatics analysis. However, little is known about the regulatory mechanisms by which lncRNAs regulate genes that are associated with Enterotoxigenic Escherichia coli F4 fimbriae (ETEC-F4ac) adhesion phenotype in small intestine epithelial cells of Large White piglets. To address this, we used RNA sequencing to profile lncRNAs and mRNAs of small intestine epithelial cells in Large White piglets differing in their ETEC-F4 adhesion phenotypes and ITGB5 genotypes. Eight male piglets were used in this study and were divided into two groups on the basis of their adhesion phenotype and ITGB5 genotypes, a candidate gene for F4ac receptor. Non-adhesive group (n = 4) with CC genotype and adhesive group (n = 4) with TT genotype.

Results

In total, 78 differentially expressed lncRNAs (DE-lncRNA) and 223 differentially expressed mRNAs (log2 |FC| > 1, P < 0.05) were identified in the comparison of non-adhesive vs. adhesive small intestine epithelial cells. Furthermore, cis- and trans-regulatory target genes of DE-lncRNAs were identified, then interaction networks of lncRNAs and their cis- and trans-target differentially expressed genes (DEGs) were constructed separately. A total of 194 cis-targets were involved in the lncRNAs-cis genes interaction network and 61 trans-targets, were involved in lncRNA-trans gene interaction network that we constructed. We determined that cis-target genes were involved in alcoholism, systemic lupus erythematosus, viral carcinogenesis and malaria. Whereas trans-target DEGs were engaged in three important pathways related to the ETEC-F4 adhesion phenotype namely cGMP-PKG signaling pathway, focal adhesion, and adherens junction. The trans-target DEGs which directly involved in these pathways are KCNMB1 in cGMP-PKG signaling pathway, GRB2 in focal adhesion pathway and ACTN4 in focal adhesion and adherens junction pathways.

Conclusion

The findings of the current study provides an insight into biological functions and epigenetic regulatory mechanism of lncRNAs on porcine small intestine epithelial cells adhesion to ETEC-F4-ac and piglets’ diarrhea susceptibility/resistance.
Exploring patient willingness to accept hepatitis C-infected kidneys for transplantation
Authors: Edwards Gretchen C. , Shipe Maren E. , Smith Lindsay , Gamble Christianna , Shaffer David , Concepcion Beatrice P. , Forbes Rachel
Published: November 2020

Background

As organs infected with Hepatitis C virus (HCV) provide an opportunity to expand the donor pool, the primary aim of this study is to explore patient willingness to accept a kidney from HCV-infected donors compared to other high-risk donors.

Methods

An anonymous, electronic survey was sent to all active kidney transplant waitlist patients at a single large volume transplant center. Patients were asked to respond to three hypothetical organ offers from the following: 1) HCV-infected donor 2) Donor with active intravenous drug use and 3) Donor with longstanding diabetes and hypertension.

Results

The survey was sent to 435 patients of which 125 responded (29% response rate). While 86 out of 125 patients (69%) were willing to accept an HCV-infected kidney, only a minority of respondents were willing to accept a kidney from other high-risk donors. In contrast to other studies, by multivariable logistic regression, age and race were not associated with willingness to accept an HCV-infected kidney.

Conclusions

In this exploratory study, utilization of kidneys from HCV-infected donors to expand the donor pool appears to be an acceptable option to patients.