bluuebunny/crossref_metadata_2025 huggingface dataset:
A Case of Posttransfusion Purpura with Severe Refractory Thrombocytopenia but No Cutaneous Manifestations
Authors: Bhamra Jagjit Singh , Iversen Per Ole , Titze Thomas Kjenner , Tjønnfjord Geir Erland , Akkök Çiğdem Akalın
Published: October 2018

Posttransfusion purpura is a serious adverse effect of transfusion due to HPA-antibodies. A young female was diagnosed with acute leukaemia, and treatment commenced. Severe thrombocytopenia ensued. No platelet increment was achieved despite transfusions with buffy coat, HLA-compatible, and HPA-1a negative platelets. The workup indicated the presence of anti-HPA-1a. When the diagnosis of posttransfusion purpura was sufficiently substantiated, she had experienced a fatal intracerebral haemorrhage.
Hypermethylation of APC2 Is a Predictive Epigenetic Biomarker for Chinese Colorectal Cancer
Authors: He Yuan , Sun Li-Yue , Wang Jing , Gong Rui , Shao Qiong , Zhang Zi-Chen , Ye Zu-Lu , Wang Hai-Yun , Xu Rui-Hua , Shao Jian-Yong
Published: October 2018

Objective. To investigate methylation of the adenomatosis polyposis coli homologue (APC2) promoter and its correlation with prognostic implications in Chinese colorectal cancer (CRC). Methods. The mRNA expression of APC2 in colorectal tissues was evaluated using the database of The Cancer Genome Atlas (TCGA). Methylation analysis of APC2 in tumor (n=66) and corresponding adjacent formalin-fixed and paraffin-embedded (FFPE) tissues (n=44) was performed by Sequenom EpiTYPER® and verified by cloning-based bisulfite sequencing analysis. Demethylation and retrieval of APC2 expression in cell lines HT29, HCT116, and SW480 were treated with 5-aza-2′-deoxycytidine (5-AZC). Results. Analysis of TCGA showed that APC2 mRNA was significantly downregulated in primary tumors when compared to normal tissues (p<0.05). APC2 methylation was upregulated (43.93% vs 7.31%, p<0.05) in tumors compared to adjacent FFPE tissues. In vitro experiments demonstrated that 5-AZC downregulated the methylation of APC2 and retrieved its expression of mRNA and protein levels (p<0.05). Multivariate Cox regression indicated that APC2_CPG_14 was an independent risk factor for overall survival (HR = 6.38, 95% CI: 1.59–25.64, p<0.05). Conclusion. This study indicates that APC2 is hypermethylated and may be a tumorigenesis biomarker for Chinese CRC patients.
Analysis of the Learning Curve of Surgeons without Previous Experience in Laparoscopy to Perform Robot-Assisted Radical Prostatectomy
Authors: Monnerat Lott Felipe , Siqueira Deborah , Argolo Hermano , Lindberg Nóbrega Bernardo , Campos Franz Santos , Favorito Luciano Alves
Published: October 2018

Objective. To assess the learning curve in robot-assisted radical prostatectomy (RARP) performed by surgeons without previous experience in laparoscopic prostatectomy. Materials and Methods. We analyzed 119 patients submitted to RARP performed by two surgeons without previous experience in laparoscopic prostatectomy, with emphasis on the relevant outcomes such as continence, erectile function, and oncologic control with a minimum follow-up of 24 months. We used Fisher’s exact test and the chi-square test to investigate the existence of a relationship between the variables and analysis of variance (ANOVA) to verify possible statistically significant differences between groups, at the 5% level. Results. The patients’ age varied from 41 to 72 years (mean = 61.09), with 68 (57.14%) cases having intermediate or high risk. There was a consistent decline in operative time. Of the 119 patients, 80.67% were continent 6 months after surgery and 89.07% 12 months afterward, while 35.29% were potent 6 months after surgery and 60.50% 12 months following surgery. Twelve months after surgery, the trifecta outcome rate was 51.26% and the pentafecta rate was 31.09%. There was progressive postoperative improvement and maintenance of continence and sexual potency until the last patient was operated in our sample. Conclusions. Robot-assisted radical prostatectomy does not require previous experience in laparoscopic radical prostatectomy, but the learning curve is not short to achieve the plateau.
A Seven-Parameter BRDF Model with Double-Peak Characteristic Suitable for Sandy Soil
Authors: Yang Yu-Feng , Li Wen-Shuai , Zhang Han-Zhi
Published: October 2018

A seven-parameter BRDF model with double-peak characteristic was proposed in this paper, which can fit double-peak data. The global genetic algorithm was used to model the BRDF experimental data of sandy soil, and the parameter values and relative mean square error of the seven-parameter BRDF model were obtained. The results proved the correctness of the model, and the relative mean square errors of this model are, respectively, 0.30%, 0.22%, 0.26%, and 0.25% corresponding to the incident angles of 15°, 30°, 45°, and 60°. Additionally, we also combined data from four incident angles to derive seven parameters, which do not depend on incident angle, and the overall error is 1.79%. Finally, in order to intuitively show the BRDF of sandy soil, 3D BRDF graph of sandy soil with different incident angles is, respectively, given. It will be of great significance in practical project applications.
Cells Lacking the RB1 Tumor Suppressor Gene Are Hyperdependent on Aurora B Kinase for Survival
Authors: Oser Matthew G. , Fonseca Raquel , Chakraborty Abhishek A. , Brough Rachel , Spektor Alexander , Jennings Rebecca B. , Flaifel Abdallah , Novak Jesse S. , Gulati Aditi , Buss Elizabeth , Younger Scott T. , McBrayer Samuel K. , Cowley Glenn S. , Bonal Dennis M. , Nguyen Quang-De , Brulle-Soumare Laura , Taylor Paula , Cairo Stefano , Ryan Colm J. , Pease Elizabeth J. , Maratea Kim , Travers Jon , Root David E. , Signoretti Sabina , Pellman David , Ashton Susan , Lord Christopher J. , Barry Simon T. , Kaelin William G.
Published: October 2018

Small cell lung cancer (SCLC) accounts for 15% of lung cancers and is almost always linked to inactivating RB1 and TP53 mutations. SCLC frequently responds, albeit briefly, to chemotherapy. The canonical function of the RB1 gene product RB1 is to repress the E2F transcription factor family. RB1 also plays both E2F-dependent and E2F-independent mitotic roles. We performed a synthetic lethal CRISPR/Cas9 screen in an RB1−/− SCLC cell line that conditionally expresses RB1 to identify dependencies that are caused by RB1 loss and discovered that RB1−/− SCLC cell lines are hyperdependent on multiple proteins linked to chromosomal segregation, including Aurora B kinase. Moreover, we show that an Aurora B kinase inhibitor is efficacious in multiple preclinical SCLC models at concentrations that are well tolerated in mice. These results suggest that RB1 loss is a predictive biomarker for sensitivity to Aurora B kinase inhibitors in SCLC and perhaps other RB1−/− cancers.

Significance:

SCLC is rarely associated with actionable protooncogene mutations. We did a CRISPR/Cas9-based screen that showed that RB1−/− SCLC are hyperdependent on AURKB, likely because both genes control mitotic fidelity, and confirmed that Aurora B kinase inhibitors are efficacious against RB1−/− SCLC tumors in mice at nontoxic doses.

See related commentary by Dick and Li, p. 169.

This article is highlighted in the In This Issue feature, p. 151
Usefulness of Non-Invasive Fetal RHD Genotyping towards Immunoprophylaxis Optimization
Authors: Blanco Sebastián , Giacomi Virginia Soledad , Slobodianiuk Luciano Gabriel , Frutos María Celia , Carrizo Luis Horacio , Fanin Gabriela Elvira , Culasso Jorge Mario , Gallego Sandra Verónica
Published: October 2018

Introduction: Since anti-D immunoprophylaxis given to D-negative pregnant women is a blood product, blood donations have an impact on the availability of prophylactic doses. The Pan American Health Organization reported, in June 2017, that less than half of blood donors are volunteers in Latin America and the Caribbean. In these countries, guidelines for use of anti-D prophylaxis are still controversial. The aim of this study was to demonstrate the convenience of a simple and cost-effectivene non-invasive prenatal diagnostic assay for anti-D prophylaxis optimization in multiethnic populations. Methods: Cell-free fetal DNA from plasma samples of D-negative pregnant women were analyzed by real-time PCR for simultaneous amplification of sequences of exons 5 and 10 of the RHD gene. Fetal RHD genotype was determined in 111 pregnant women. Neonates' phenotype was determined 72 h after birth. Results: Genotyping predicted fetal phenotype with 100% accuracy. Prenatal diagnosis showed 78% RHD-positive and 22% RHD-negative neonates. Conclusion: We demonstrated that, beyond the large genetic variation of the Rh system and the numerous D variants present in multiethnic groups, non-invasive fetal RHD genotyping using two sequences of the gene can be enough for clinical application in an admixed population. This robust technique of simple implementation allows to determine fetal RHD in maternal blood with high sensitivity, specificity, and accuracy. The introduction of fetal RhD genotyping as part of an antenatal screening program constitutes a reliable manner to optimize anti-D prophylaxis; however, it has not been implemented so far in most American countries.
Adjuvant Chemotherapy of Locally Advanced Colon Cancer: Final Results of a Randomized Trial Comparing 5-Fluorouracil and Folinic Acid with Folfiri
Authors: Paschke Stephan , Hebart Holger , Goeb Roland , Staib Ludger , Fleck Ullrich , Henne-Bruns Doris , Sander Silvia , Link Karl-Heinrich , Kornmann Marko
Published: October 2018

Background: There is still the need to optimize adjuvant treatment of colon cancer (CC). Standard adjuvant chemotherapy using 5-fluorouracil (FU) and folinic acid (FA) was compared with a combination including irinotecan (Folfiri). The aim of the present report was to analyze overall survival (OS) after long-term follow-up, to summarize final recurrence rates and toxicity data, and to identify possible clinical and pathological factors associated with prognosis. Methods: Patients (CC stage IIb and III) were randomized to a 6-month treatment with FUFA or Folfiri. The trial was closed after 275 of 588 planned patients, 269 of which were included in the intention-to-treat analysis. Results: 133 and 136 patients received FUFA and Folfiri, respectively. Adjuvant therapy was not completed for 16 FUFA (12.0%) and 44 Folfiri (32.4%) patients. Toxicities grade III and IV were observed in 17 (12.8%) patients treated with FUFA and in 50 (36.8%) patients treated with Folfiri. Recurrences occurred in 46 of 133 (34.6%) and in 47 of 136 (34.6%) patients who received FUFA and Folfiri, respectively. 5-year OS rates were 69.9% (95% confidence interval (CI): 61.2-77.1) for FUFA and 72.7% (95% CI: 63.9-79.8) for Folfiri. OS was associated with tumor grading (1 & 2 vs. 3), tumor sub-stage (II vs. IIIa vs. IIIb vs. IIIc), and tumor location (left vs. right colon). Conclusion: Folfiri cannot be generally recommended for adjuvant chemotherapy of CC. Besides tumor grading and sub-staging, prognosis of CC may depend on tumor location. Left-sided tumors had a significantly better prognosis irrespective of treatment.
Application of a Three-Dimensional Reconstruction System in Breast Cancer with Ipsilateral Supraclavicular Lymph Node Metastasis: A Case Series
Authors: Zhao Piao , Zou Qiongyan , Yuan Liqin , Li Lun , Chen Qitong , Ouyang Dengjie , Yi Wenjun
Published: October 2018

Background: The role of supraclavicular lymph node dissection (SCLND) in breast cancer patients with ipsilateral supraclavicular lymph node metastasis (ISLM) remains controversial. So far, there have been no effective imaging methods to precisely judge the feasibility of SCLND and the modes of ISLM. Case Report: We innovatively applied a three-dimensional (3D) reconstruction system to assess the feasibility of SCLND preoperatively for 13 breast cancer patients with ISLM. Based on the 3D reconstruction system and intraoperative findings, we performed lymph node dissection of their lesion areas. Compared to computed tomography or ultrasonography, the 3D reconstruction system found more lymph nodes not only in the ipsilateral supraclavicular area but also in other areas in which metastasis may occur (p < 0.05), and provided visual images pertaining to the relationship between the lymph nodes and major blood vessels, nerves, and muscles. Conclusion: The 3D reconstruction system could significantly benefit the precise assessment of the lesion area and facilitate subsequent relevant surgery.
Hyperthermic Intraperitoneal Chemotherapy - Fading Perspective in the Light of Modern Systemic Chemotherapy?
Authors: Garg Pankaj Kumar , Brandl Andreas , Rau Beate
Published: October 2018

Background: Peritoneal metastasis (PM) in a gastrointestinal cancer is associated with a poor prognosis. Various guidelines recommend palliative chemotherapy in these patients as cure is not achievable. However, hyperthermic intraperitoneal chemotherapy (HIPEC) in combination with cytoreductive surgery (CRS) can achieve long-term survival with low morbidity in selected patients. During the last decades, CRS and HIPEC have been performed in a number of indications, aiming for long-term survival. What is more, new drugs and treatment regimens demonstrate favorable results. Methods: The recently published important literature on PM in gastrointestinal cancer was analyzed. Results: Resection of isolated PM in a gastrointestinal cancer should be considered, and HIPEC is feasible. However, there is a lack of well-designed randomized controlled trials (RCTs) in gastrointestinal cancer-related PM. Many RCTs are being conducted across the world whose results will be available in 1-2 years. Systemic chemotherapy alone as an adequate management plan for isolated PM in a gastrointestinal cancer is not compatible with a high standard of care. Formulating an optimal plan combining the benefits of CRS and HIPEC coupled with systemic chemotherapy is a necessary task of the multidisciplinary team. Proper selection of the patients for CRS and HIPEC is necessary to achieve maximal oncological benefit and minimal perioperative morbidity and mortality. Conclusions: A multidisciplinary approach combining the benefits of both CRS and HIPEC, and systemic chemotherapy is the way forward to manage those patients with gastrointestinal cancer and PM. Further studies are warranted to identify the selection variables for CRS and HIPEC.
First Report of Low-Rate Mosaicism for 20q11.21q12 Deletion and Delineation of the Associated Disorder
Authors: Loddo Sara , Alesi Viola , Genovese Silvia , Orlando Valeria , Calacci Chiara , Restaldi Fabrizia , Pompili Daniele , Liambo Maria T. , Digilio Maria C. , Dallapiccola Bruno , Dentici Maria L. , Novelli Antonio
Published: October 2018

Interstitial deletions of the long arm of chromosome 20 are very rare, with only 12 reported patients harboring the 20q11.2 microdeletion and presenting a disorder characterized by psychomotor and growth delay, dysmorphisms, and brachy-/clinodactyly. We describe the first case of mosaic 20q11.2 deletion in a 5-year-old girl affected by mild psychomotor delay, feeding difficulties, growth retardation, craniofacial dysmorphisms, and finger anomalies. SNP array analysis disclosed 20% of cells with a 20q11.21q12 deletion, encompassing the 20q11.2 minimal critical region and the 3 OMIM disease-causing genes GDF5, EPB41L1, and SAMHD1. We propose a pathogenic role of other genes mapping outside the small region of overlap, in particular GHRH (growth hormone releasing hormone), whose haploinsufficiency could be responsible for the prenatal onset of growth retardation which is shared by half of these patients. Our patient highlights the utility of chromosomal microarray analysis to identify low-level mosaicism.
Paving the Way for Therapy: The Second International Conference of the Trisomy 21 Research Society
Authors: Reeves Roger H. , Delabar Jean , Potier Marie-Claude , Bhattacharyya Anita , Head Elizabeth , Lemere Cynthia , Dekker Alain D. , De Deyn Peter , Caviedes Pablo , Dierssen Mara , Busciglio Jorge
Published: October 2018

In the last decade, a number of important research advances in different fields have allowed Down syndrome (DS) research to flourish, creating a time of both unparalleled opportunity and considerable challenge. Building a scientific framework that distills mechanisms involved in the developmental intellectual disability of DS as well as the early-onset component of Alzheimer disease and the several other comorbidities associated with the condition is a challenge that scientists are now tackling using novel technologies and multidisciplinary approaches. The Trisomy 21 Research Society (T21RS) was founded in 2014 to address these evolving needs and challenges. In June of 2017, the T21RS held its 2nd International Conference in Chicago, USA. With more than 200 scientists, advocates, people with DS, and family members in attendance, the meeting served as a forum for the discussion of the latest research and clinical advances as well as the most compelling needs of people with DS and their families.
Thrombogenic and Arrhythmogenic Roles of the Left Atrial Appendage in Atrial Fibrillation
Authors: Di Biase Luigi , Natale Andrea , Romero Jorge
Published: October 2018

Understanding the anatomy, physiology, and arrhythmogenic and thrombogenic roles of the left atrial appendage (LAA) has become very important. The potential deleterious effects of this chamber in patients with atrial fibrillation have led to the development of specific treatments for this structure. It has been established that the LAA is the area where the vast majority of thrombi in nonvalvular atrial fibrillation are formed and that some LAA morphologies may actually facilitate thrombi formation and risk stratification for thromboembolic events in patients with low CHA
2
DS
2
-VASc scores. Likewise, clinical data supporting the role of LAA electric isolation to improve freedom from all-atrial arrhythmias are rapidly growing. Acute LAA electric isolation can be achieved in most cases of catheter ablation for atrial fibrillation. However, late LAA reconnections are frequent. Special considerations should be taken when this procedure is performed to avoid myocardial perforation, left phrenic nerve, and left circumflex coronary artery damage. LAA electric isolation is a safe procedure that does not increase the risk of stroke as long as patients remain compliant with lifelong anticoagulation regardless of CHA
2
DS
2
-VASc score. Finally, ligation of the LAA has recently been associated with modulation of the renin-angiotensin-aldosterone system with clinical implications in blood pressure control.
Climbing the Ladder: Socioeconomic Mobility in Malaysia
Authors: Khalid Muhammed Abdul
Published: October 2018

This study investigates the existence and extent of intergenerational mobility in Malaysia in terms of educational attainment, occupational skills level, and income level. It compares the status of working adults born between the years 1945 and 1960 and their adult children born between 1975 and 1985, using non-linear transition matrix techniques. On average, the majority of adult children have better educational attainment and occupational skills level compared with their parents. Income mobility, in absolute and relative terms, is highest among children born to parents in the lowest income quintile. The results of a logistic regression model show that education, assets ownership, gender, and location matter for upward mobility. Moving forward, there will be difficulties for the children from poor families to move up the socioeconomic ladder because of changes in policies. An inclusive development approach is vital in enhancing socioeconomic mobility to promote social cohesion, economic growth, and greater equity for the next generation.
Sustainable Development and Currency Exchange Rate Behavior
Authors: Ariff Mohamed , Zarei Alireza
Published: October 2018

We discuss currency volatility as a measure of currency instability using 15 currencies from developed and emerging economies. The IMF and others have recorded how countries manage their exchange rates to promote sustainable economic growth by designing exchange rate regimes as a pillar within economic policy. The findings herein show how to track currency instability using a given currency's volatility against the volatility of a benchmark currency of importance to the given currency. This is termed relative volatility. The study proceeds to test whether the parity factors and country risk factor are significantly correlated with exchange rate relative volatility.
The ‘Third Hand’ in Egypt
Authors: Wessel Sarah
Published: October 2018

This article seeks to complement current research on the international dimension of the recent transformations in the Arab world by focusing on the subjective domestic political debates on external actors in Egypt. Approaching political transformations in post-revolutionary Egypt (2010–2014) as dynamic and reciprocal processes of claim making and receiving, I explore how the representations of external actors served as an important source for the military to legitimize the continuous expansion of its political powers. By doing so, I hope to illuminate on a period that was celebrated as a departure towards democracy, yet regressed into the re-emergence of a military regime three years later. Drawing from empirical findings gained in a multi-sited long-term field study from 2010 to 2014, I show that the ‘third hand’ – a concept that is commonly used in the streets, the media and in political speeches to designate external interventions as attempts to undermine the stability of the country – had a major impact on the transformations. The article shows how the exploration of domestic public debates is key to a better understanding of the international dimension in political transformations.
A new species of Tabularia (Kützing) Williams & Round from Poyang Lake, Jiangxi Province, China, with a cladistic analysis of the genus and their relatives
Authors: CAO YUE , YU PAN , YOU QINGMIN , LOWE REX L. , WILLIAMS DAVID M. , WANG QUANXI , KOCIOLEK JOHN PATRICK
Published: October 2018

A new species of Tabularia, Tabularia sinensis, is described from the inland Poyang Lake (Jiangxi Province), the largest lake in China. The description is based on light and scanning electron microscope observations of valve and girdle elements. Given the diversity of forms in the genus, the relationships and status of the genus was investigated in the context of the other known species in the genus and to ascertain if Tabularia, as originally circumscribed, remains monophyletic.
A new diatomspecies of Aneumastus D. G. Mann & Stickle ((Bacillariophyta, Bacillariophyceae, Mastogloiales, Mastogloiaceae) from Tibet, China
Authors: LIU QI , YANG LIN , NAN FANGRU , FENG JIA , LV JUNPING , KOCIOLEK JOHN PATRICK , XIE SHULIAN
Published: October 2018

A new species, Aneumastus yamdrokensis Liu & Xie, is described from Yamdrok Lake, collected during a survey of the freshwater diatom flora of Tibet, China. The valves of this new species are elliptical-lanceolate with rounded apices and have the features typical of the genus, including complex areolae. The morphology of A. yamdrokensis is documented with light and scanning electron microscopy, described in detail, and compared with the most similar taxa, including A. minor Lange-Bertalot and A. densistriatus.
A taxonomic study of Eupolyphaga Chopard, 1929 (Blattodea: Corydiidae: Corydiinae)
Authors: QIU LU , CHE YANG-LI , WANG ZONG-QING
Published: October 2018

The cockroach genus Eupolyphaga is revised. Twenty species and two subspecies are recognized, with thirteen species and two subspecies are new to science: E. daweishana sp. nov., E. dongi sp. nov., E. fengi sp. nov., E. hanae sp. nov., E. hupingensis sp. nov., E. maculata sp. nov., E. nigrifera sp. nov., E. nigrinotum sp. nov., E. pilosa sp. nov., E. robusta sp. nov., E. shennongensis sp. nov., E. wooi sp. nov., E. xuorum sp. nov., E. everestiana reni subsp. nov., and E. fengi yongshengensis subsp. nov. Homœogamia sinensis Saussure is placed as a junior synonym of E. sinensis (Walker) and the replaced name E. limbata (Kirby) for Homœogamia sinensis is invalid, the status of Eupolyphaga thibetana (Chopard) is recovered. Male genitalia of species in the genus is described and illustrated. Females and oothecae of some species are described and illustrated. Distribution maps and a checklist of Eupolyphaga are provided. A key to males of Eupolyphaga is given. Plenty habitat photographs are shown.
Re-description of Chinese mitten crab Eriocheir sinensis H. Milne Edwards, 1853 (Crustacea: Brachyura: Grapsoidea: Varunidae) zoeal development using confocal laser scanning microscopy
Authors: KAMANLI SEYIT A. , MORRITT DAVID , BALL ALEXANDER D. , GORAL TOMASZ , CLARK PAUL F.
Published: October 2018

A number of authors have described the zoeal development of the Chinese mitten crab, Eriocheir sinensis H. Milne Edwards, 1853, while some of these studies only recognised 5 zoeal stages, two of them described six. The present study re-examined the zoeal stages of E. sinensis from laboratory-reared material using confocal laser scanning microscopy and visualised the images using the open-source software programmes ImageJ and Drishti. From these images 6 zoeal stages were re-described and compared with all previous larval descriptions of the Chinese mitten crab. Comments on the variation of some setal characters are also described in zoeal stages IV−VI.
Extratropical Cyclones: A Century of Research on Meteorology’s Centerpiece
Authors: Schultz David M. , Bosart Lance F. , Colle Brian A. , Davies Huw C. , Dearden Christopher , Keyser Daniel , Martius Olivia , Roebber Paul J. , Steenburgh W. James , Volkert Hans , Winters Andrew C.
Published: October 2018

The year 1919 was important in meteorology, not only because it was the year that the American Meteorological Society was founded, but also for two other reasons. One of the foundational papers in extratropical cyclone structure by Jakob Bjerknes was published in 1919, leading to what is now known as the Norwegian cyclone model. Also that year, a series of meetings was held that led to the formation of organizations that promoted the international collaboration and scientific exchange required for extratropical cyclone research, which by necessity involves spatial scales spanning national borders. This chapter describes the history of scientific inquiry into the structure, evolution, and dynamics of extratropical cyclones, their constituent fronts, and their attendant jet streams and storm tracks. We refer to these phenomena collectively as the centerpiece of meteorology because of their central role in fostering meteorological research during this century. This extremely productive period in extratropical cyclone research has been possible because of 1) the need to address practical challenges of poor forecasts that had large socioeconomic consequences, 2) the intermingling of theory, observations, and diagnosis (including dynamical modeling) to provide improved physical understanding and conceptual models, and 3) strong international cooperation. Conceptual frameworks for cyclones arise from a desire to classify and understand cyclones; they include the Norwegian cyclone model and its sister the Shapiro–Keyser cyclone model. The challenge of understanding the dynamics of cyclones led to such theoretical frameworks as quasigeostrophy, baroclinic instability, semigeostrophy, and frontogenesis. The challenge of predicting explosive extratropical cyclones in particular led to new theoretical developments such as potential-vorticity thinking and downstream development. Deeper appreciation of the limits of predictability has resulted from an evolution from determinism to chaos. Last, observational insights led to detailed cyclone and frontal structure, storm tracks, and rainbands.
Seasonal Forecasting of Onset of Summer Rains over South Africa
Authors: Ratnam J. V. , Doi Takeshi , Landman Willem A. , Behera Swadhin K.
Published: October 2018

In this study, we attempted to forecast the onset of summer rains over South Africa using seasonal precipitation forecasts generated by the Scale Interaction Experiment–Frontier Research Center for Global Change, version 2 (SINTEX-F2), seasonal forecasting system. The precipitation forecasts of the 12-member SINTEX-F2 system, initialized on 1 August and covering the period 1998–2015, were used for the study. The SINTEX-F2 forecast precipitation was also downscaled using dynamical and statistical techniques to improve the spatial and temporal representation of the forecasts. The Weather Research and Forecasting (WRF) Model with two cumulus parameterization schemes was used to dynamically downscale the SINTEX-F2 forecasts. The WRF and SINTEX-F2 precipitation forecasts were corrected for biases using a linear scaling method with a 31-day moving window. The results indicate the onset dates derived from the raw and bias-corrected model precipitation forecasts to have realistic spatial distribution over South Africa. However, the forecast onset dates have root-mean-square errors of more than 30 days over most parts of South Africa except over the northeastern province of Limpopo and over the Highveld region of Mpumalanga province, where the root-mean-square errors are about 10–15 days. The WRF Model with Kain–Fritsch cumulus scheme (bias-corrected SINTEX-F2) has better performance in forecasting the onset dates over Limpopo (the Highveld region) compared to other models, thereby indicating the forecast of onset dates over different regions of South Africa to be model dependent. The results of this study are important for improving the forecast of onset dates over South Africa.
ENSO-Related Global Ocean Heat Content Variations
Authors: Wu Quran , Zhang Xuebin , Church John A. , Hu Jianyu
Published: October 2018

The modulation of the full-depth global integrated ocean heat content (GOHC) by El Niño–Southern Oscillation (ENSO) has been estimated in various studies. However, the quantitative results and the mechanisms at work remain uncertain. Here, a dynamically consistent ocean state estimate is utilized to study the large-scale integrated heat content variations during ENSO events for the global ocean. The full-depth GOHC exhibits a cooling tendency during the peak and decaying phases of El Niño, which is a result of the negative surface heat flux (SHF) anomaly in the tropics (30°S–30°N), partially offset by the positive SHF anomaly at higher latitudes. The tropical SHF anomaly acts as a lagged response to damp the convergence of oceanic heat transport, which redistributes heat from the extratropics and the subsurface layers (100–440 m) into the upper tropical oceans (0–100 m) during the onset and peak of El Niño. These results highlight the global nature of the oceanic heat redistribution during ENSO events, as well as how the redistribution process affects the full-depth GOHC. The meridional heat exchange across 30°S and 30°N is driven by ocean current anomalies, while multiple processes contribute to the vertical heat exchange across 100 m simultaneously. Heat advection due to unbalanced mass transport is distinguished from the mass balanced one, with significant contributions from the meridional and zonal overturning cells being identified for the latter in the vertical direction. Results presented here have implications for monitoring the planetary energy budget and evaluating ENSO’s global imprints on ocean heat content in different estimates.
Mixed Rossby–Gravity Wave–Wave Interactions
Authors: Eden Carsten , Chouksey Manita , Olbers Dirk
Published: October 2018

Mixed triad wave–wave interactions between Rossby and gravity waves are analytically derived using the kinetic equation for models of different complexity. Two examples are considered: initially vanishing linear gravity wave energy in the presence of a fully developed Rossby wave field and the reversed case of initially vanishing linear Rossby wave energy in the presence of a realistic gravity wave field. The kinetic equation in both cases is numerically evaluated, for which energy is conserved within numerical precision. The results are validated by a corresponding ensemble of numerical model simulations supporting the validity of the weak-interaction assumption necessary to derive the kinetic equation. Since they are generated by nonresonant interactions only, the energy transfers toward the respective linear wave mode with vanishing energy are small in both cases. The total generation of energy of the linear gravity wave mode in the first case scales to leading order as the square of the Rossby number in agreement with independent estimates from laboratory experiments, although a part of the linear gravity wave mode is slaved to the Rossby wave mode without wavelike temporal behavior.
Impact of Slant-Path Radiative Transfer in the Simulation and Assimilation of Satellite Radiances in Environment Canada’s Weather Forecast System
Authors: Shahabadi Maziar Bani , Aparicio Josep M. , Garand Louis
Published: October 2018

Slant satellite-viewing geometry is investigated for the simulation and assimilation of radiances in Environment Canada’s weather forecast system. The standard approach is to extract from a short-term forecast (trial field) a one-dimensional vertical profile, located at the ground footprint of the observation location, to compute the model equivalent of the observation. Since in general, the lines of sight are not vertical, the observation operator can be improved by interpolating the trial field to the slant path. The interpolation relies on the estimation of horizontal gradients of atmospheric variables, extracted at each altitude layer, and representative of a neighborhood of approximately 100 km. Using these slant profiles of the trial fields yields significant improvements in the simulation and assimilation of radiance observations. The impact of this modification in assimilation and forecasts is evaluated over two periods of two months. Both short-term and long-term effects are found, obtained not only from the more accurate interpolation of the trial fields, but also from a revision of the observation error suggested by the lower observation minus trial field difference statistics. The error standard deviation of the geopotential height shows, in the upper troposphere and lower stratosphere, in 12–48-h forecasts, up to 10% reduction in the zonal value at higher latitudes, and 1%–2% reduction in the global value. Given these improved statistics, a revision of the radiance error statistics was explored. Applying these revised statistics suggests that the impact of a slant operator extends into longer range.
Multiscale Characteristics of Different-Source Perturbations and Their Interactions for Convection-Permitting Ensemble Forecasting during SCMREX
Authors: Zhang Xubin
Published: October 2018

The multiscale characteristics of initial conditions (ICs), model physics (MO), and lateral boundary conditions (LBCs) perturbations, as well as their interactions, are investigated for an experimental convection-permitting ensemble prediction system used in southern China, with a focus on 32 12-h forecasts collected over a half-month period of the Southern China Monsoon Rainfall Experiment (SCMREX) in May 2014. Forecast perturbations differed from each other in terms of magnitude, evolution, and vertical distribution between components at different scales. The meso-β-scale MO perturbations show faster growth and saturation, as well as larger magnitude than the meso-α-scale ones, especially in the presence of moist convection. For IC perturbations, damping was present for nonprecipitation variables, while rapid growth and saturation occurred for precipitation. Adding LBCs perturbations to IC or MO perturbations caused linear impacts, which caused consistent, although small, perturbation increments. Nonlinear impacts of adding MO perturbations to IC perturbations were evident and were intrinsic to the predictability limits of IC and MO perturbations, which were closely related to moist dynamics. These nonlinear impacts had the most significant effects on meso-β-scale precipitation perturbations and can effectively improve precipitation prediction. These results highlight the importance of developing multiscale and multisource perturbation methods that reasonably include the interactions among different-scale perturbations from different sources, especially the nonlinear impacts of adding MO perturbations to IC perturbations.
Attitudes of Residents and Program Directors Towards Research in Otolaryngology Residency
Authors: Mansi Ahmed , Karam Wade N. , Chaaban Mohamad R.
Published: October 2018

Objective:

To determine attitudes of residents and program directors towards research during residency training.

Study Design:

Survey of current otolaryngology residents and program directors.

Setting:

Otolaryngology residency programs.

Methods:

An anonymous web-based survey ( www.surveymonkey.com ) was sent to 106 program directors (PDs) and 115 program coordinators. The program coordinators subsequently sent it to residents. Fisher exact tests and correlations were used to determine statistically significant differences.

Results:

Overall, 178 residents and 31 PDs responded to our surveys. All residents surveyed reported some research experience prior to residency. Residents who reported a previous first-author manuscript publication prior to residency were more likely than residents who had no previous first-author publication to report a first-author publication during residency (58.44% vs 27.27%, P < .0001); 33% of the residents reported academics as a desired future career setting after residency. The most significant barrier to research perceived by the residents was time constraint due to residency duties and personal commitments (93% and 74%, respectively). The second and third most common barriers to research were lack of statistical knowledge at 52% and lack of interest in research at 43.6%.

Conclusions:

Research is a required component of otolaryngology residency training. The most significant barrier in our survey was the lack of protected research time, followed by lack of biostatistical knowledge and interest. Program directors may need to implement structured research rotations tailored to individual residents’ research interests and integrate training in research methodology and biostatistics.
Reduced cortical thickness in subjects at clinical high risk for psychosis and clinical attributes
Authors: Kwak Yoo Bin , Kim Minah , Cho Kang Ik Kevin , Lee Junhee , Lee Tae Yong , Kwon Jun Soo
Published: October 2018

Objectives:

Although neuroanatomical abnormalities in subjects at clinical high risk for psychosis have been considered a putative biomarker of psychosis, relevance of cortical thickness alterations remains contested due to discrepant findings. Inconsistencies persist in Asian clinical high risk studies, despite their advantageous settings well-controlled for confounds. Attributes of cortical thickness alterations in clinical high risk subjects warrant further examination.

Methods:

We examined cortical thickness at the whole-brain level in 74 clinical high risk subjects and 34 demographically matched healthy controls recruited from Seoul Youth Clinic, South Korea. Clinical symptoms were assessed using the Scale of Prodromal Symptoms, and their associations with cortical thickness were explored using partial correlation analysis.

Results:

Compared to healthy control, clinical high risk exhibited significant cortical thinning in bilateral prefrontal cortex and inferior parietal lobule clusters. Reduced thickness in the left prefrontal cortex cluster was associated with more severe Scale of Prodromal Symptoms general symptoms scores and the right inferior parietal lobule cluster with Scale of Prodromal Symptoms disorganization symptoms.

Conclusions:

Thickness deficits found in the present clinical high risk sample demonstrated a degree of consistency with those reported in the previous Seoul Youth Clinic study. While inconsistencies reported between the present and previous Seoul Youth Clinic samples may reflect markedly decreased rate of converters, consistencies may be relevant to clinical attributes beyond transition, such as the prevalence of comorbidities. Particular recruitment strategies employed for sample selections should also be considered for findings in Asian clinical high risk samples. Our results suggest potential utility of cortical thickness alterations in clinical high risk subjects beyond the frame of transition.
Evaluation of a Language and Literacy Enhancement Program
Authors: Yaun Jason , Bach Mimi , Bakke Josh , Goedecke Patricia J. , Baldwin Katherine McCaa , Hare Marion
Published: October 2018

Reading aloud to children encourages language development. Pediatricians promote reading practices through Reach Out and Read (ROR) and other methods. This exploratory study sought to examine the value that supplemental materials promoting “Touch, Talk, Read, Play” (TTRP) might provide in addition to ROR. This study was a pre- and postintervention design to assess response to the TTRP curriculum. Caregivers of children ages 12 to 24 months completed the communication portion of the Ages and Stages Questionnaire–Third Edition and a Literacy Education Survey to assess current literacy practices. The caregiver and child were then introduced to the TTRP materials. Data were obtained on 98 subjects preintervention with follow-up data collected on 30 participants 6 months later. Significant differences were found in the Ages and Stages Questionnaire scores and parent-reported importance of reading and conversing frequently with their child. TTRP provides an effective curriculum for literacy promotion in a ROR program.
Lack of Utility in Performing Blood Glucose Measurement and Electrocardiogram in the Outpatient Evaluation of Benign Pediatric Syncope
Authors: Gupta Ayush , Bonadio William
Published: October 2018

We aimed to determine the frequency of blood glucose and electrocardiogram (EKG) abnormalities in previously healthy children who present to an emergency department (ED) with a diagnosis of benign syncope. Chart review of consecutive children aged 5 to 18 years presenting to the pediatric ED from 2004 to 2014 with a discharge diagnosis of benign syncope was done. Of 969 patients, hypoglycemia (serum glucose <60 mg/dL) was present in only 3 cases (0.3%). Of 754 patients with EKG performed, only 4 cases (0.6%) was an abnormality requiring further cardiac evaluation identified; cardiac echocardiogram was performed in 3 of these 4 patients, which revealed no cardiac pathology. Financial analysis for performing blood glucose measurement and EKG on these patients amounted to total health care cost of $222 526. We concluded that previously healthy children with syncope rarely have hypoglycemia or underlying cardiac abnormality. The routine performance of tests can incur significant health care expenditure.
Integration of the Safe Environment for Every Kid (SEEK) Model Across Primary Care Settings
Authors: Eismann Emily A. , Theuerling Jack , Maguire Sabine , Hente Elizabeth A. , Shapiro Robert A.
Published: October 2018

This project sought to assess the generalizability, barriers, and facilitators of implementing the Safe Environment for Every Kid (SEEK) model for addressing psychosocial risk factors for maltreatment across multiple primary care settings, including a pediatric practice, federally qualified health center, and family medicine practice. The SEEK model includes screening caregivers for psychosocial risk factors at well-child visits age 0 to 5 years, brief intervention incorporating principles of motivational interviewing to engage caregivers, and referral to treatment. All practices successfully implemented SEEK, with screening completion rates from 75% to 93% and brief intervention rates from 61% to 81%. Major parental stress (14%) and food insecurity (11%) were the most common risk factors. Providers found SEEK worthwhile for improving their knowledge, skills, and ability to address psychosocial concerns and provide whole person care. Barriers included limited time and resources, incomplete resource knowledge, and lack of follow-up. Facilitators included on-site support staff to assist with communication and referrals.
Targets, Grievances, and Social Movement Trajectories
Authors: Simmons Erica S.
Published: October 2018

Why do targets of social movement activities respond to movements in the ways they do? Many factors play a role in shaping targets’ responses to social movement activities. This article focuses on one particular factor: targets’ perceptions of social movement claims. The article argues that a target’s understanding of a social movement’s claims helps shape its response, which, in turn, shapes the evolution of the social movement. Two cases of social mobilization, one in response to water privatization in Bolivia and the other in response to rising corn prices in Mexico, serve as a lens through which to explore these issues. In each case, differences in how public authorities understood the movements’ claims help explain why they reacted in starkly different ways to the emerging movements. Where officials appreciated the symbolic value of the good at stake, they acted quickly to curtail resistance. Where officials failed to grasp those meanings, they dismissed the potential for widespread mobilization and inadvertently accelerated movement growth.
The Relationship Between Open Enrollment and School Bond Voting
Authors: Pogodzinski Ben , Lenhoff Sarah Winchell , Addonizio Michael
Published: October 2018

Purpose: The purpose of this study was to identify an association between student mobility through open enrollment and voter support for school bond proposals. Specifically, we hypothesized that higher percentages of nonresident enrollment in a school district and resident exit from a district would be associated with lower levels of voter support for bond proposals. Data Collection and Analysis: We utilized publicly available data on bond proposals placed on ballots between 2009 and 2015, publicly available data from the State of Michigan for information on percentages of nonresident enrollment and resident exit, and publicly available data from the U.S. Census Bureau for data on district resident characteristics. Regression analysis was used to identify associations between nonresident enrollment and resident exit with the percentage of “yes” votes on school bond proposals controlling for community and resident characteristics. Findings: We failed to reject the null hypotheses, finding no statistically significant association between nonresident enrollment and resident exit and average voter support for school bond proposals, ceteris paribus. Implications for Research/Practice: We laid some groundwork for reconceptualizing the relationship between open enrollment policies and communities’ willingness to support local public schools. This has potential implications for both local- and state-level policies regarding enrollment issues and issues of school finance. As local boards continue to struggle with budget shortfalls and mounting capital needs, they may need to further weigh their own communities’ interest in supporting local public schools in the wake of increased student mobility in and out of districts.