bluuebunny/crossref_metadata_2025 huggingface dataset:
Vedolizumab serum trough concentrations with and without thiopurines in ulcerative colitis: The prospective VIEWS pharmacokinetics study
Authors: Chaemsupaphan Thanaboon , Pudipeddi Aviv , Lin Hui-Yu , Paramsothy Sudarshan , Kariyawasam Viraj C , Kermeen Melissa , Leong Rupert W
Published: December 2024

BACKGROUND

Ulcerative colitis (UC) is a chronic inflammatory condition requiring continuous treatment and monitoring. There is limited pharmacokinetic data on vedolizumab during maintenance therapy and the effect of thiopurines on vedolizumab trough concentrations is unknown.

AIM

To investigate the exposure-response relationship of vedolizumab and the impact of thiopurine withdrawal in UC patients who have achieved sustained clinical and endoscopic remission during maintenance therapy.

METHODS

This is a post-hoc analysis of prospective randomized clinical trial (VIEWS) involving UC patients across 8 centers in Australia from 2018 to 2022. Patients in clinical and endoscopic remission were randomized to continue or withdraw thiopurine while receiving vedolizumab. We evaluated vedolizumab serum trough concentrations, presence of anti-vedolizumab antibodies, and clinical outcomes over 48 weeks to assess exposure-response association and impact of thiopurine withdrawal.

RESULTS

There were 62 UC participants with mean age of 43.4 years and 42% were females. All participants received vedolizumab as maintenance therapy with 67.7% withdrew thiopurine. Vedolizumab serum trough concentrations remained stable over 48 weeks regardless of thiopurine use, with no anti-vedolizumab antibodies detected. Patients with clinical remission had higher trough concentrations at week 48. In quartile analysis, a threshold of > 11.3 μg/mL was associated with sustained clinical remission, showing a sensitivity of 82.4%, specificity of 60.0%, and an area of receiver operating characteristic of 0.71 (95%CI: 0.49-0.93). Patients discontinuing thiopurine required higher vedolizumab concentrations for achieving remission.

CONCLUSION

A positive exposure-response relationship between vedolizumab trough concentrations and UC outcomes suggests that monitoring drug levels may be beneficial. While thiopurine did not influence vedolizumab levels, its withdrawal may necessitate higher vedolizumab trough concentrations to maintain remission.
Fitocheminių ir kitų natūralių medžiagų naudojimas androgeninei alopecijai gydyti
Authors: Cibulskaitė Robertina , Mažeika Erikas , Petkevičius Arūnas
Published: December 2024

Tyrimo tikslas. Išanalizuoti tyrimus, kuriuose nagrinėjami nemedikamentiniai androgeninės alopecijos gydymo būdai – fitocheminės medžiagos ir kiti natūralūs produktai – jų veiksmingumą ir taikymą klinikinėje praktikoje. Metodai. Atlikta literatūros apžvalga naudojant tarptautinę medicinos duomenų bazę „PubMed“. Straipsniai atrinkti vartojant reikšminius žodžius: „androgeninė alopecija“, „natūralios medžiagos“, „augalinės kilmės“, „plaukų slinkimas“. Kiti įtraukimo kriterijai: straipsniai, parašyti anglų kalba ir ne senesni nei 10 metų. Rezultatai ir išvados. Kofeinas, rozmarino aliejus, ženšenis, kapsaicinas, kurkuminas bei procianidai skatina plaukų augimą ir ilgina anageno fazę. Epigalokatechino galatas, gulsčioji serenoja bei moliūgų sėklų aliejus slopina dihidrotestosterono gamybą. Reikalingi daugiacentriai klinikiniai tyrimai, siekiant išsamiau ištirti šių natūralių produktų poveikį ir įvertinti jų veiksmingumą bei taikymo galimybes klinikinėje praktikoje.
Fizinio aktyvumo įtaka depresija sergančių asmenų gyvenimo kokybei
Authors: Dovydėnaitė Eglė , Micakitė Beatričė , Varžaitytė Lina
Published: December 2024

Tyrimo tikslas. Išanalizuoti mokslinę literatūrą apie fizinių pratimų įtaką depresija sergančių asmenų gyvenimo kokybei. Metodai. Tyrimo metu atlikta literatūros apžvalga. Duomenys surinkti iš duomenų bazių „PubMed“, „ScienceDirect“. Analizuoti straipsniai buvo publikuoti nuo 2000 iki 2024 m. 81 proc. straipsnių buvo ne senesni nei penkerių metų. Atrinkti ir išanalizuoti 26 straipsniai, atitinkantys tyrimo temą. Rezultatai. Fiziniai pratimai gali sumažinti depresijos simptomus, veikdami tiek biologinius, tiek psichosocialinius mechanizmus. Kai kurie tikėtini biologiniai mechanizmai, galintys lemti teigiamą fizinio krūvio poveikį, yra smegenų neurotrofinio faktoriaus (BDNF) stimuliavimas, sumažėjęs uždegimas ir oksidacinis stresas, prefrontalinės žievės ir hipokampo stimuliavimas, sustiprėjęs pagumburio, hipofizės ir antinksčių žievės ašies aktyvumas, įskaitant struktūrinius smegenų pokyčius, kuriuos gali sukelti ilgalaikis kortizolio poveikis bei sustiprėjęs noradrenerginių, dopaminerginių ir serotonerginių neuronų impulsų perdavimas. Saviveiksmingumo ir meistriškumo hipotezės teorija nurodo, kad atlikus svarbią ir daug pastangų reikalaujančią užduotį, pvz., fizinių pratimų sesiją, kyla meistriškumo jausmas, kuris gerina nuotaiką. Remiantis dėmesio atitraukimo hipoteze, fiziniai pratimai padeda nukreipti dėmesį nuo nerimo ir depresyvių minčių, taip mažinant stresą ir depresijos simptomus.Išvados. Aerobiniai, jėgos ir proto bei kūno pratimai gali palengvinti depresijos simptomus depresija sergantiems pacientams, sukeldami antidepresinį poveikį dėl daugelio biologinių ir psichosocialinių mechanizmų.
Pasikartojančios vulvovaginalinės kandidozės gydymas
Authors: Liškauskaitė Raminta
Published: December 2024

Sėkmingas pasikartojančios vulvovaginalinės kandidozės gydymas – klinikinis iššūkis tiek medikams, tiek pacientėms. Antimikrobinio atsparumo vystymasis, bioplėvelės formavimasis bei ne Candida albicans padermių įsivyravimas didina sukėlėjų patogeniškumą ir mažina gydymo veiksmingumą. Vietiniai arba geriamieji azolių grupės priešgrybeliniai vaistai padeda sumažinti ligos atsinaujinimo dažnį. Nors epizodinis gydymas flukonazolu kartais būna veiksmingas, siekiant išvengti dažnų ligos pasikartojimų, būtina ilgalaikė palaikomoji priešgrybelinė terapija. Ji gali būti papildyta boro rūgštimi, nistatinu arba probiotikais. Siekiant palengvinti pasikartojančios vulvovaginalinės kandidozės simptomus, svarbios inovatyvios strategijos. Taip pat vertinamos naujos gydymo galimybės – otesekonazolas, ibreksafungerpas. Šioje literatūros apžvalgoje aptariami tiek pagrindiniai, gerai žinomi preparatai, tiek nauji pasikartojančios vulvovaginalinės kandidozės gydymo metodai.
Aproximación del cómic al alumnado valenciano. La exposición itinerante «Imágenes de la Memoria Democrática»
Authors: Sigüenza Felipe
Published: December 2024

Imágenes de la Memoria Democrática: el cómic como recurso didáctico es una exposición destinada a las aulas. A través de viñetas y de textos explicativos, propone una visión de la historia de España que va de principios del siglo XX al inicio de la Transición. La asesoría de Geografía e Historia del CEFIRE Humanístico y Social de la Comunidad Valenciana la ha elaborado contando con las obras de autores tan reconocidos como Paco Roca, Antonio Altarriba o Sento y con los textos preparados por la Cátedra Interuniversitaria de Memoria Democrática. Desde noviembre de 2018, se ha puesto a disposición de los docentes de la comunidad esta herramienta que aúna cómic, historia, memoria democrática y metodologías activas.
Re-presentación de la Guerra civil y del franquismo en Montserrat, Jeunesse bafouée y Paris Liberté de Julio Ribéra
Authors: THOUVEREZ LUDIVINE , GONZÁLEZ MEDIANO David
Published: December 2024

Este artículo analiza el relato memorial histórico que ofrece el autor catalán Julio Ribéra (1927-2018) en su trilogía de la memoria, publicada entre 2004 y 2006 en Francia. Exiliado en París en la década de los 50, Ribéra alcanzó fama por sus obras de ciencia ficción o de corte fantástico. En los años 2000, coincidiendo con el inicio del debate sobre la memoria histórica en España, realiza una obra autobiográfica compuesta de tres álbumes: Montserrat. Souvenirs de la guerre civile (2004), Jeunesse bafouée. Une dictature au fil des jours (2005) y Paris Liberté. Le parfum de l'espoir (2006). La singularidad de esta obra nos lleva a plantear las siguientes cuestiones: ¿en qué medida supone la trilogía una ruptura respecto a las obras de ciencia ficción que Ribéra realizó antes? ¿Qué relación mantiene con la realidad histórica? ¿Cómo se documenta y se plasma la memoria individual y colectiva en ella? Basándonos en los aportes teóricos de Thierry Groensteen sobre arte secuencial, y de Isabelle Delorme y Bart Beaty sobre el relato autobiográfico o memorial histórico en el cómic, presentaremos la génesis de la obra, su particular visión partidista de la guerra civil, el recurso en ella del realismo y de la subjetividad, así como su aportación a la mejor comprensión de la obra de Ribéra.
Entrevista con Ana Miralles y Emilio Ruíz
Authors: YEXUS
Published: December 2024

Tras su debut en 1982 en la revista Rambla, la madrileña Ana Miralles (1959) publica en la ya mítica Madriz y dibuja la serie Marruecos, mon amour, con guion de Antonio Segura para la revista Cairo. Con el mismo autor realiza la trilogía Eva Medusa, que le abre las puertas del mercado francés, y también En busca del unicornio, una adaptación de Emilio Ruíz (Santander, 1960) de la novela homónima de Juan Eslava Galán. Es decir, el mismo guionista con quien había firmado su primer monográfico, El brillo de una mirada. Pero su consagración europea llega con Djinn, escrita por el veterano Jean Dufaux, un best-seller del que se publican 13 álbumes entre 2001 y 2016. En 2009 recibió el Gran Premio del Salón de Barcelona a toda su trayectoria. De nuevo con Ruíz (fotógrafo, documentalista y diseñador) dibuja De mano en mano y la inconclusa Muraqqa e inicia en 2011 la serie infantil Wáluk, de la que han aparecido tres álbumes. Su más reciente producción es Ava, centrada en una estancia de 47 horas de la actriz Ava Gardner en Río de Janeiro.
Rafael Carrión Arias. Batman and the Shadows of Modernity. A Critical Genealogy on Contemporary Hero in the Age of Nihilism
Authors: Hormaechea Ocaña Andrea
Published: December 2024

Reseña de la obra de Rafael Carrión, Batman and the Shadows of Modernity. A Critical Genealogy on Contemporary Hero in the Age of Nihilism
Análisis de los Derechos del Trabajador en el Ámbito de la Pesca Industrial
Authors: Zamora Casquete Mayerly Valentina , Piloso Moreira Verónica Alexandra
Published: December 2024

La industria pesquera en Ecuador ha evolucionado significativamente, con impacto directo en las condiciones laborales y los derechos de los trabajadores. Este artículo analiza el marco normativo que rige el sector, incluyendo la Constitución de la República, el Código de Trabajo y la Ley Orgánica de Navegación, en relación con la seguridad, la estabilidad laboral y la remuneración justa. A través de una metodología de análisis documental, se destacan las condiciones de vulnerabilidad en la pesca industrial y la necesidad de fortalecer la protección de los trabajadores mediante regulaciones más estrictas, acceso a la capacitación y garantías de participación sindical. Los hallazgos subrayan que, pese a los avances normativos, persisten retos en la implementación efectiva de políticas laborales que aseguren condiciones dignas y equitativas en un sector de alta variabilidad y riesgo.
Oftalmopatía Externa como forma debutante de Mutación del gen polg, en estado heterocigoto, en la posición c.3323a>t, p.tyr1108phe. A propósito de un caso.
Authors: Carrillo Hernández Melissa , López Reyes Braulio Esteban , Martínez Tovar Irma , Hernández Cisneros Luis Gerardo , Rodriguez Rodriguez Zahira Nahetzy
Published: December 2024

La mutación POLG es una patología mitocondrial causada por alteraciones en el gen POLG que puede ser heredada de manera autosómica dominante o autosómica recesiva, también puede aparecer como una nueva mutación en individuo sin antecedentes familiares de enfermedad. La prevalencia de la enfermedad resulta complicada, debido a la heterogeneidad clínica y al infra diagnóstico. En función de los aspectos clínicos se clasifica en dos grupos: formas de inicio infantil y formas de inicio más tardío, su cuadro clínico dependerá del inicio de la enfermedad. El diagnóstico se fundamenta en la sospecha clínica, sugerida por los datos de la anamnesis y la exploración física apoyado inicialmente por los resultados de exploraciones complementarias generales y específicas de disfunción mitocondrial. Los defectos de mantenimiento del ADN mitocondrial son trastornos graves con mal pronóstico en la mayoría de las personas afectadas, no existe una terapia curativa para ninguno de estos trastornos, siendo principalmente sintomático. A propósito, se presenta un caso de mutación del gen POLG, en estado heterocigoto, en la posición c.3323A>T, p.Tyr1108Phe en un adolescente; quien acude por presentación progresiva de pérdida de fuerza muscular de miembros inferiores, claudicación e incapacidad para la deambulación, iniciando abordaje multidisciplinario.
Political Communication, Neuroscience and Ethics: Challenges for the power of managing and predicting political consumer behaviors
Authors: Torres Hidalgo Martha Silvia , Mendieta Ramírez Angélica
Published: December 2024

In the field of Political Communication, one of the most important tasks is the management of information, it is known that information is power and more so if it is about transmitting information for the creation of messages that may be able to identify with an electoral public, which then leads this to the decision of the voters. Hence, political campaigns seek to invest in the creation of more effective messages for the expected return of a winning candidate. Faced with these new challenges and trends in predicting the behavior of the electorate, a multidisciplinary science called political neuromarketing emerges that, based on specific techniques, messages and stimuli conquer the emotions of its audiences. It is for the above that this research presents a state of the art on the challenges of the power of management and the prediction of electoral consumer behavior under the multidisciplinary approach of Political Communication, Neuroscience and Ethics. Among the most important findings of this new paradigm of political neuromarketing is the presence of technical and ethical dilemmas in practice that must be considered for a framework of action that does not disrupt values ​​and health in the mind of the future electoral consumer.
Qualidade da Água do Sistema Lagunar de Jacarepaguá: Análise dos Parâmetros Hidroquímicos e suas Implicações Ambientais
Authors: Pinto Emanuele Koschier , Cruz Anna Nachtigall da , Milani Idel Cristiana Bigliardi
Published: December 2024

Este trabalho teve como objetivo analisar as condições hidroquímicas do Sistema Lagunar de Jacarepaguá (RJ) a fim de identificar as principais problemáticas desse ecossistema. A pesquisa foi realizada por meio da análise dos dados hidroquímicos disponibilizados pelo programa de monitoramento do INEA, no período de 2018 a 2022, sendo esses dados comparados com a legislação vigente. A investigação revelou uma escassez de informações devido a falhas nos monitoramentos realizados pelo órgão responsável, o que dificultou a tabulação e interpretação dos resultados. Os principais problemas identificados incluem o despejo de efluentes in natura nas lagoas e na bacia hidrográfica, o crescimento desordenado da urbanização no entorno e a ausência de saneamento básico adequado, fatores que comprometem a qualidade das águas. A análise mostrou que as condições de qualidade da água são críticas em vários pontos do sistema, com diversos parâmetros fora dos padrões estabelecidos pela legislação, o que impede o uso múltiplo das águas da região. Dessa forma o ideal seria a implementação de medidas de recuperação em todo o sistema, contudo entende-se que por questões financeiras, as ações devem ser pensadas com cautela, buscando recuperar os corpos lagunares em uma relação de custo-benefício. Cabe destacar que além de promover melhoria na qualidade da água do sistema lagunar como um todo, a recuperação deste ambiente aquático trará melhorias na qualidade de vida da população do entorno, já que a qualidade das águas possui relação direta com a saúde e o bem-estar da comunidade local.
View on various clinical determinants of thyroid neoplasms based on their histopathological patterns
Authors:   Department of Pathology, College of Medicine, AL- Iraqia University, Baghdad, Iraq, Mohsin Hadeel Ismail , Mohammed Murooj Jassim ,   Department of Pathology, College of Medicine, AL-Iraqia University, Baghdad, Iraq, Ahmed Basim Shehab ,   Ibn Sina University of Medical and Pharmaceutical Sciences, Baghdad, Iraq, Albayati Asaad F. ,   Department of Pathology, College of Medicine, AL-Iraqia University, Baghdad, Iraq
Published: December 2024

Background. Most thyroid cancers are differentiated, either follicular or papillary, and respond effectively to radioactive iodine therapy. Aim of study. To investigate the histopathological types of thyroid cancer and their relationship to certain demographic and clinical characteristics. Methods. A retrospective observational study with an analytic component was conducted over six months (May to November 2023). It included 120 patients diagnosed with thyroid cancer, selected from oncology department records. The following information was collected: age, gender, occupation, smoking status, family history of thyroid malignancy, tumor stage according to the 7th edition of the American Joint Committee on Cancer Staging, thyroid status, clinical presentation, ultrasound details, and histopathological report. Results. In this study, 68.3% of cases presented as goiter, and lymphadenopathy was observed in 18.3%. The most prevalent histological type was papillary carcinoma. Of the papillary cases, 80.6% were staged as T1, compared to 23.5% of follicular carcinoma cases. In papillary carcinoma, 38.9% had a tumor size < 1 cm³, while 76.5% of follicular carcinoma cases had a tumor size > 2 cm³. Lymphadenopathy was seen in 47.1% of follicular carcinoma cases, compared to 11.1% in papillary carcinoma cases. Regarding clinical presentation, goiter was found in 72.2% of papillary cases compared to 17.6% of follicular cases, with these differences being statistically significant. Conclusion. Thyroid cancer is more common in younger age groups and in females. The papillary form accounts for the majority of cases, suggesting that iodine deficiency is not a significant factor for most patients. Histopathological features may help predict the degree of lymph node metastasis.
Thermal Optimalization with CFD Analysis and Real-Time Performance Identification in Briquette Ovens Using Modbus-Based Communication
Authors: Hiron Nurul , Busaeri Nundang , Nursuwars Firmansyah Maulana Sugiartana , Sambas Aceng , Wulandana Rachmadian
Published: December 2024

Briquette ovens that utilize biomass energy frequently face obstacles in achieving consistent heat distribution, resulting in ineffective energy usage and varying product quality. This study tackles these challenges by merging Computational Fluid Dynamics (CFD) analysis, performed with Cradle software, alongside a Modbus-based temperature data acquisition system to significantly boost energy efficiency and temperature regulation. A total of 32 K-type thermocouples were meticulously positioned within the oven to gather real-time temperature data, which was processed through LabVIEW. CFD simulations revealed irregular heat distribution patterns, especially at the rear of the oven. The temperature data obtained via Modbus corroborated these observations, allowing for strategic modifications to enhance heat distribution and minimize energy loss. The system achieved an impressive accuracy rate of 98.89%, with a mere error margin of 1.11%, substantially elevating the oven’s energy efficiency and briquette drying capabilities. This research clearly illustrates that the integration of CFD modeling with real-time data acquisition constitutes a powerful method for optimizing the functionality of industrial heating systems.
Recomendaciones para el mes de Febrero
Authors:   Centro Nacional de Investigaciones de Café
Published: December 2024

El déficit hídrico acentuado en gran parte de la región cafetera podrá afectar la disponibilidad de agua para los próximos meses. Continúan las condiciones secas que podrán afectar el desarrollo y crecimiento de la planta y el llenado del fruto.
Recomendaciones para el mes de Septiembre
Authors:   Centro Nacional de Investigaciones de Café
Published: December 2024

Durante el mes de septiembre continúa una condición normal en el océano Pacífico.
Atlas Cafetero de Colombia
Authors:   Federación Nacional de Cafeteros de Colombia
Published: December 2024

En 1932, siendo Gerente de la Federación el doctor Mariano Ospina Pérez, se realizó un Censo Cafetero a nivel nacional, obra de gran mérito si se tiene en cuenta las dificultades que se presentaban en la época, especialmente las referencias a las vías de comunicación. A este trabajo, digno de recordar, lo ilustraron Mapas Cafeteros de Colombia que tuvo amplia divulgación, especialmente fuera del país.
MSME Perception in Preparing Financial Reports According to Indonesian SAK for MSMEs
Authors: NIDA Desak Rurik Pradnya Paramitha , LEDA Thereza Gradeno , ADYATMA I Wayan Chandra , YOGA I Gusti Agung Prama
Published: December 2024

ABSTRACTThe Indonesian Financial Accounting Standards for EMKN (Micro, Small, and Medium Entities) are the basis for preparing financial statements set by the Indonesian Institute of Certified Public Accountants. Financial statements are compiled to provide information on the financial position and performance of the entity so that users can make decisions. He also showed management accountability for the resources recorded to him. However, in practice, many MSMEs still need to learn about it. We use a narrative qualitative method to describe the reality of the implementation of SAK and its implications in the company: data collection techniques and in-depth interviews on MSMEs engaged in the culinary sector. The informants involved are the owner, manager, and accountant. The urgency of this study is that the role of MSMEs in driving the economy is very significant. However, financing still needs to be improved due to the unavailability of financial report data (Nida, 2024). This study will provide an overview of MSMEs' perspectives on preparing financial statements under Indonesian SAK for MSMEs.
Exploring the Effects of Information and Communication Technology as a Pedagogy for Teaching Business Studies in Grade 10 in the Lejweleputswa Education District, South Africa
Authors: Mashabe Masilo Pule David , Modise Motalenyane Alfred
Published: December 2024

This research explored the effect of Information and Communication Technology as a pedagogy for teaching Business Studies in Grade 10. The participants were educators from three high schools in the Lejweleputswa Education District, from the Free State province, South Africa. However, they revealed that the adoption of ICT needs diverse development in terms of curriculum, educators’ training and development, assessment strategies, educators’ competence and various forms of teaching strategies. Thematic analysis revealed that ICT has a great and positive effect as a pedagogy because educators will be able to explain and transmit content knowledge to learners to meet the curriculum goals and objectives. This research recommends that, in order to declare the use of ICT as a pedagogy for teaching Grade 10 Business Studies in Lejweleputswa Education District. Educators need to be competent. Training and development need to be done as a commitment to advance learners with skills set for being future business people. The seeks to offer strategies for the Department of Basic Education (DBE) at the provincial, regional and district levels to be consistent and effective in supplying ICT apparatus across the province to ensure quality of education and sufficient transfer of skills. It should be acknowledged that the goal of ICT in schools is to inculcate learners with technological skills in order to mend and respond to the requirements of the Fourth Industrial Revolution (4IR) as well as Artificial Intelligence (AI).

Keywords: Information and Communication Technology, The Effect of ICT, Pedagogy, Teaching, Business Studies
Audit independence and customer relationship marketing: an ethical conflict or an ethical mutual effect?
Authors: Martins Gabriel G. , Casais Beatriz
Published: December 2024

Independence in financial auditing is a topic with extensive research, due to the ethical values expected from accountants and the conflicts with agency pressures and commercial interests. However, there is a lack of research on the benefits of ethical behaviors in the dynamic interactions between auditors and clients. This study aims to achieve through a qualitative approach an in-depth understanding of the self-perceived auditor independence and how it intervenes in the relationship with clients. Ten semi-structured interviews with auditors from the five major audit offices in the city of Porto were conducted. The results explore conflicts of interest between auditor independence and customer relationships. However, the findings highlight that improving auditor’s independence allows at the same time the development of a better professional relationship with the client, mitigating the conflicts of interests identified in previous literature. This paper presents a formula in which audit firms can leverage the concept of independence when they promote communication, transparency, and an open market. Regulation and supervision should work in favour for the same goal.
Vocalizations of Atelopus ignescens (Cornalia, 1849): The repertoire of a resilient species that whispers not to disappear
Authors: Batallas Diego , Guayasamin Juan M. , Vega-Yánez Mateo A.
Published: December 2024

The Atelopus (or harlequin frogs) have become a symbol of the ongoing efforts to conserve biodiversity in Ecuador over the past few decades. Atelopus ignescens, also known as jambato, was previously considered to be an extinct species until it was rediscovered in the Andean locality of Angamarca, Ecuador. This study presents and describes the calls of Atelopus ignescens for the first time. These are low intensity sounds that comprise a repertoire of three distinct call types: tonal, short and pulsed call. They have different spectral and temporal characteristics. The most notable difference in their structure is the presence or absence of pulses and the frequency modulation observed in tonal calls. In terms of spectral characteristics, the mean dominant frequency is 1.7 kHz, with up to 11 harmonics visible. A peculiar feature of the Jambato is the absence of a tympanic middle ear, a characteristic observed in the majority of Atelopus species. The absence of these structures, however, does not mean that harlequin toads are deaf since they seem to have extratympanic mechanisms of audition. It is our hope that our contribution will stimulate further research into the bioacoustics and behavior of this endangered and relatively unknown group of anurans.
In silico investigation and in vivo effect of Berastagi orange (Citrus sinensis) peel extract on male obese rats
Authors: Prasetyo Andika , Batubara Winda Rizki Pebrina , Indarto Dono , Susilawati Tri Nugraha
Published: December 2024

Our previous studies show that Berastagi orange peel extract (BOPE) has anti-obesity properties, indicated by its active compounds and effects on reducing body weight gain and body fat percentage. This present study further analysed the effects of BOPE by evaluating docking analysis of BOPE’s phytochemicals and measuring lipid profiles, atherogenic indexes, triglyceride metabolism-related proteins (CD36, DGAT1, and DGAT2) levels, and dipeptidyl peptidase-4 (DPP4) activity in high-fat high-fructose (HFHFr)-induced obese rats. Docking analysis shows that BOPE’s phytochemicals, i.e., naringenin and hesperidin, potentially inhibit CD36 and DGAT1. BOPE significantly reduced LDL cholesterol, triglyceride levels, and DPP4 activity while increasing HDL cholesterol levels. BOPE also improved atherogenic indexes, indicating that BOPE has anti-atherosclerotic and cardioprotective effects. However, no significant effect was observed in the levels of triglyceride metabolism-related proteins, thus warranting further research towards the development of BOPE as a nutraceutical product for obesity prevention and treatment.
Les luttes socio-écologiques en Amérique latine
Authors: Löwy Michael , Fernandes Sabrina
Published: December 2024

Dans cet entretien, Sabrina Fernandes revient sur son parcours, entre découverte du marxisme, engagement écosocialiste et efforts de transmission d’armes critiques pour penser une transition radicale et une résistance au capitalisme vert. Elle dresse un état des forces en présence sur le front écosocial en Amérique du Sud, dont la composition mêle à l’écomarxisme les luttes indigènes, les combats écoféministes, les enjeux fonciers et alimentaires, l’Amazonie, et les perspectives de résistance face au regain de l’exploitation minière dans le cadre du capitalisme vert qui redéploie et renouvelle les « zones de sacrifice ». Surtout, elle souligne l’impératif de penser la transition écologique non comme un agenda de réformes sectorielles, mais comme un programme politique, à partir duquel organiser la liaison des luttes et une vision transformatrice commune. Sabrina Fernandes propose quelques moyens de compréhension pour faire avancer ce front écosocial sud-américain et sa dimension internationaliste – les enjeux décrits ici mettant en jeu les débats sur les modalités de la bifurcation écologique dans les pays riches.
Le dopage sur un marché « Winner-Takes-All »
Authors: Bourg Jean-François
Published: December 2024

L’acte de dopage se caractérise par trois critères : une action illicite avec la transgression d’une règle ; une stratégie pour se procurer un avantage concurrentiel ; un risque incompressible et inévitable lié à la nature même de la compétition sportive. Ne pas se doper équivaut à une exclusion certaine de la compétition pour la victoire. Or seul le « vainqueur rafle la mise » !
Les compétences culturelles comme solutions pour lutter contre les biais dans les relations thérapeutiques interculturelles : Scoping Review
Authors: Dauvrin Marie , Khalifeh Riwa , Saliba Christiane , Salameh Pascale , d’Hoore William
Published: December 2024

Objectif : Cette revue a pour objectif d’explorer l’utilisation des compétences culturelles (CC) pour répondre aux problèmes de biais dans la relation thérapeutique interculturelle. Elle vise également à décrire les différents modèles et référentiels de CC adoptés au Moyen-Orient. Méthodes : Un processus méthodologique de Scoping Review a été suivi. Une identification des études potentielles s’est fondée sur des critères d’inclusion définis selon le protocole PCC (Population, Concept, Contexte). Un diagramme de PRISMA y est ensuite établi. Les dates de publication des études incluses dans la revue s’étendent de 2001 à 2022. Le nombre total d’articles retirés est de 15. Un relevé de thèmes a été établi. Résultats : Dans un contexte interculturel, la formation des professionnels de santé (PS) aux CC favorise la diminution des disparités en matière de soins de santé. À cet effet, elle offre aux PS les outils et les connaissances dont ils ont besoin pour traiter tous les patients de manière égale, quelle que soit leur origine culturelle. Cependant, de nombreux facteurs individuels et organisationnels affecteraient l’application des CC, outre les stratégies d’enseignement stéréotypées générées lors des formations. Peu d’études portant sur les CC, voire aucune, ont été menées dans les pays du Moyen-Orient. Conclusion : Il incombe aux prestataires de soins de santé et aux organisations concernées d’acquérir les CC afin de promouvoir un environnement de compréhension et de respect favorable à la prestation de soins. Conduire des recherches et des études supplémentaires pourrait ouvrir de nouveaux horizons et inciter à l’élaboration de nouvelles lignes directrices des CC dans les pays du Moyen-Orient.
Moving Mountains and Swallowing Seas: Śaiva Gurus as Ecological Agents in Early South and Southeast Asia
Authors: Cecil Elizabeth A.
Published: December 2024

The worship of Śiva in early South and Southeast Asia offered devotees a fully realized “religious ecology,” i.e., a system of mutually beneficial relationships between human communities, natural systems, and the nonhuman or more-than-human worlds in which they operated. Within this religious worldview, the Śaiva guru functioned as a critical terrestrial intermediary. In canonical early Śaiva texts, the guru was celebrated as an ecological agent capable of alleviating suffering and nurturing community. In material culture, the guru’s iconographic attributes (e.g., waterpot, trident, and lotus) signaled his ability to offer devotees emotional, social, and environmental benefits.
Using the figure of the Brahmanical sage and Śaiva guru Agastya as an entrée, this study initiates a comparative analysis of the cultural connections between gurus, Śiva worship, and the power of the natural world as expressed through iconographic programs and architectural spaces from northern India, Vietnam, and Java. Since Agastya is both a personification of Brahmanical cultural authority and a transregional emblem of the Śaiva tradition, he provides a fertile ground from which to explore the role of the guru in early South and Southeast Asia. Agastya’s mythic biography also features two significant environmental interventions: subduing the Vindhya Mountain when it threatened to block out the sun, and drinking the ocean’s waters to reveal hidden demons threatening a divine order. His ecological agency, expressed in narratives as the power to neutralize potential threats in the natural world and manifest beneficence, is materialized in images that express the socially supportive values of prosperity and fertility.
Rock, Paper, Scissors: Durable Ephemera and Networks of Stone in Quanzhou’s Zhenguo Pagoda
Authors: Purtle Jennifer
Published: December 2024

Building a pagoda mobilizes durable materials into architectonic form. But a pagoda may also incorporate likenesses of images and objects wrought in ephemeral materials, thus becoming a nexus of textual, pictorial, and formal transfer and intermedial preservation. This essay examines how, in the Zhenguo pagoda 鎮國塔 (lit. “Defender of the State Pagoda”) at the Kaiyuan temple in Quanzhou, Fujian, rock—covered with the imagery of paper (and other fugitive media) by means of scissors (or, more precisely, the carver’s knife)—preserved traces of evanescent forms. Specifically, it: articulates the relationship of paper-based editions of the Buddhist canon to the pagoda’s stone-carved narrative program; asserts the influence of logographic schema of printed-paper primers and locally known, silk-based court painting styles to the pagoda’s imagery; and contends that carved images of small, free-standing bronze (and stone) pagodas link the Zhenguo pagoda to overlapping local (Quanzhou), regional (Min-Yue/Fujian), imperial (Song-dynasty), and maritime (Indian Ocean) object networks. To test the hypothesis that the Zhenguo pagoda serves as a repository of, and lexicon for, now lost forms, this essay concludes by using the imagery of the Zhenguo pagoda to recover the iconography of a type of Quanzhou-specific Buddhist monument, the Stone Shoot (Shisun 石筍).
Les « grottes-sanctuaires » gallo-romaines du Morbihan, éléments d’une géographie du sacré chez les Vénètes
Authors: Galliou Patrick
Published: December 2024

Dans le Morbihan, trois cavités naturelles, grottes et abris sous roche, explorées de façon sommaire à la fin du xixe siècle et au début du siècle suivant, ont livré un abondant mobilier archéologique d'époque romaine, essentiellement constitué de statuettes de terre blanche (Vénus, déesses-mères, etc.). Il s'agit, selon toute vraisemblance, d'endroits où était pratiquée une propitiation des divinités souterraines, visant à obtenir de celles-ci des récoltes abondantes. On ne connaît pas, à ce jour, d'autres exemples de telles utilisations de lieux souterrains à l'époque romaine dans la péninsule armoricaine.
La lecture jeunesse en breton, une clé de compréhension de la situation sociolinguistique de Bretagne, entre enjeux, représentations et pratiques
Authors: Rouxel Eve
Published: December 2024

Cet article propose d'envisager les bouleversements sociolinguistiques de ce dernier siècle sous l'éclairage de la lecture en breton, et plus largement de la perception de la langue écrite. Alors que le nombre de locuteurs du breton a chuté de façon vertigineuse et que les 60 ans et plus représentent aujourd'hui près de 80 % des locuteurs, le nombre de publications en langue bretonne a connu lui une augmentation sans précédent, et en particulier dans le domaine de la littérature de jeunesse qui représente plus de la moitié des publications ces dernières années. L'étude des enjeux autour de la langue bretonne écrite, des pratiques effectives de lecture des jeunes et des attentes de leurs parents dans ce domaine vient questionner l'évidence d'une convergence des attentes autour du bilinguisme par le biais de l'école, et souligne les logiques différentes en œuvre chez des acteurs que l'on aurait a priori placé dans la même structure de distribution, mais dont il apparaît qu'ils ne « jouent » pas nécessairement selon les mêmes règles.
Le diable à Cîteaux : le procès pour sorcellerie de Regnault Robergeot (1480-1481)
Authors: Gelly-Perbellini Maxime
Published: December 2024

Cet article est la présentation du procès pour sorcellerie de Regnault Robergeot (décembre 1480-janvier 1481) conduit par la justice temporelle de l’abbaye de Cîteaux, qui détenait cette compétence à Corcelles-lès-Cîteaux. Le document édité, conservé aux Archives départementales de la Côte-d’Or (11 H 450), contient le procès-verbal de l’interrogatoire du sorcier ainsi que la sentence le condamnant à être brûlé vif sur le bûcher. Ce procès, faisant suite à une première procédure (aujourd’hui perdue) menée par l’Inquisition dominicaine, offre un exemple rare de judiciarisation et de condamnation de la sorcellerie diabolique par l’ordre cistercien à la fin du Moyen Âge. Il donne ainsi l’occasion d’observer la circulation, la pénétration et l’adaptation de l’imaginaire du sabbat au cœur de l’ordre de Cîteaux. Il montre également que cette condamnation de la sorcellerie est intimement liée aux transformations de l’espace politique bourguignon à la fin des années 1470 ainsi qu’aux logiques d’affirmation de l’autorité et de la souveraineté du chef de l’Ordre des moines blancs durant l’abbatiat de Jean de Cirey (1476-1503).
Future Cyber Physical System Security
Authors: Kathirvel Naren , Ayyaswamy Kathirvel , Gunasekaran K.
Published: December 2024

Over the past few decades, the manufacturing industry has become a hotbed of research on the rapidly developing trend of smart technology. Numerous cutting-edge technologies, including the internet of things, industrial internet of things (IOT), cyberphysical production systems, artificial intelligence, block chains, and systematic data analysis, were included in smart technology (ST). In order to close the gap between humans and machines, we give an overview of various smart technologies that can be used to regulate the sophisticated characteristics of computer and sensor technologies. The entire literature review on ST to improve machinery equipment production and maintenance, as well as prospective threats to ST, is presented in this research article. Additionally, the survey report comparing the adoption rate currently to that of the previous five years is included in this article in order to reduce the amount of human labor required in the industrial industry through the use of various sensors, cost-effective methodologies, and real-time outcomes.
Breaking Barriers
Authors: Tyson Jia
Published: December 2024

This chapter addresses disability bias within corporate DEIB initiatives, emphasizing the need to consider both visible and invisible disabilities. It examines best practices through case studies on neurodiversity in multinational corporations, employment outcomes for individuals with hearing disabilities, diversity management's impact on financial performance, purple hiring practices, and challenges in work-integrated learning and disclosure of invisible disabilities. The chapter advocates for a holistic, intersectional approach and improved data collection to enhance disability inclusion and offers practical recommendations for eliminating bias and fostering equity in the workplace.
Unveiling Workplace LGBTQ+ Inclusion
Authors: Amancherla Sowmya , Balasundaram Sathiyaseelan
Published: December 2024

In recent years, the discourse on LGBTQ+ inclusion within professional environments has gained considerable traction. This study aims to comprehensively assess current workplace policies aimed at fostering LGBTQ+ inclusion, analyze their effectiveness on professional experiences and well-being, and identify barriers hindering full inclusivity. Key findings highlight the critical influence of workplace policies on LGBTQ+ inclusion levels, pinpointing areas for policy enhancement to cultivate more inclusive environments. Best practices identified include the implementation of inclusive language, diversity training programs, and the establishment of support networks tailored to LGBTQ+ employees. Importantly, the study underscores how fostering LGBTQ+ inclusion not only enhances employee well-being and satisfaction but also confers competitive advantages to organizations by attracting top talent and bolstering their reputation as socially responsible employers.
Ethical Leadership and Diversity, Equity, Inclusion, and Belonging
Authors: Jay Ashli D.
Published: December 2024

This study examines the role of ethical leadership in driving Diversity, Equity, Inclusion, and Belonging (DEIB) across four industries: energy, telecommunications, automotive and transportation, and hospitality and tourism. Through a case study approach, the research explores the strategies implemented by organizations to overcome industry-specific challenges and achieve meaningful DEIB outcomes. Key findings highlight the importance of ethical leadership in fostering inclusive cultures, with cross-industry insights revealing common success factors and obstacles. The study also identifies gaps in existing research, emphasizing the need for future studies to further explore the impact of ethical leadership on DEIB across diverse sectors. The results offer practical guidance for organizations seeking to enhance their DEIB efforts through ethical leadership, ultimately contributing to more inclusive and equitable workplaces globally.
Blockchain-Based Knowledge Management System
Authors: Shusha Fasel Qadir
Published: December 2024

Blockchain technology has become a prominent trend in both academia and the IT sector. Initially introduced by Satoshi Nakamoto in 2008 as the core technology for Bitcoin, it aimed to create a secure, decentralized platform for financial transactions. The blockchain concept gained traction with Bitcoin's rise and is now seen as a transformative innovation. Its applications extend to various fields such as banking, healthcare, education, IoT, and cryptography. Blockchain is valued for addressing inefficiencies in traditional systems by offering enhanced security, transparency, and data integrity. This chapter explores how blockchain can enhance knowledge management systems (KMSs) by improving data repositories, collaboration, peer review, intellectual property management and so on. It aims to showcase blockchain's potential to revolutionize these systems.
Blockchain-Based Knowledge Sharing and Collaboration
Authors: Eswaran Ushaa , Eswaran Vivek , Murali Keerthna , Eswaran Vishal
Published: December 2024

This chapter explores the intersection of blockchain technology and knowledge sharing systems, examining how distributed ledger technology can revolutionize collaboration and information exchange across various domains. We investigate the potential of blockchain to create secure, transparent, and decentralized platforms for knowledge management, addressing current challenges in traditional systems such as data silos, lack of trust, and inefficient information flow. Through a comprehensive literature review, methodology discussion, and analysis of relevant case studies and experimental research, we demonstrate the transformative impact of blockchain on knowledge sharing practices. The chapter also delves into future trends and potential applications, providing insights into the evolving landscape of blockchain-based collaboration systems.
Blockchain Interoperability
Authors: Jain Alice , Jhajharia Kavita
Published: December 2024

Blockchain technology has gained significant attention for its potential to revolutionize various industries by offering decentralized and immutable data storage and transaction mechanisms. This book chapter investigates the critical issue of blockchain interoperability and evaluates various solutions proposed to address this challenge. The chapter begins by providing an overview of blockchain interoperability, highlighting its importance in realizing the full potential of blockchain technology. It discusses the limitations of existing blockchain networks and described the need of interoperability. The chapter delves into an in-depth analysis of different approaches to achieve blockchain interoperability. These include interoperability protocols such as atomic swaps, sidechains, notary schemes, hashed time locks and cross-chain communication protocols, as well as interoperability frameworks. Finally, this chapter underscores the significance of blockchain interoperability as a catalyst for the widespread adoption and integration of blockchain technology into existing infrastructures.
Blockchain-Powered Collaboration in Spatial Data Infrastructure
Authors: Ahmad Munir
Published: December 2024

Blockchain is being adopted in different sectors such as health strategies and services, production chains, school systems and business management, manufacturing, emergency response systems, farming and food production, travel and hospitality, and power distribution. Indeed, this makes it also relevant for the consideration of the SDI. This chapter explored the potential of blockchain technology for SDI and examined its potential role in addressing key areas of concern regarding SDI: Governance Structure, Features that make an institution more accessible, Capacity Building, and Interoperability of Data. In addition, the chapter also offers a reflection on the implications that may be associated with integrating the blockchain technique into SDI. Some of the difficulties include system deployment, technical issues, legal issues, and permissions besides being aspects of cost and resource concerns.
Grading the Blockchain Using Sharding
Authors: Pramanik Sabyasachi , Bag Soma , Roy Atanu
Published: December 2024

Concerns about blockchain's scalability have grown in importance as its use expands. This problem is addressed by sharding protocols, which divide the blockchain network into smaller, more manageable chunks called shards. Each shard manages a distinct set of smart contracts and transactions on its own. This matching step greatly increases a blockchain network's overall throughput. This chapter provides an overview of blockchain technology, examines its fundamental components and operations, and discusses the role that sharding protocols play in improving the scalability and efficiency of the platform. Various sharding approaches have been compared and evaluated. It has also been argued where future research on blockchain technology sharding should go.