bluuebunny/crossref_metadata_2025 huggingface dataset:
NON-MOTOR SYMPTOMS OF PARKINSON DISEASE
Authors:   Department of Neurology and Fundamentals of Medical Genetics, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan, ZARIPOV N.A. , DODKHOEV J.S. ,   Department of Pediatric Diseases № 1, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan, ABDULLOZODA S.M. ,   Department of Epidemiology, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan, JAMOLOVA R.J. ,   Department of Internal Medicine № 3, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan
Published: March 2023

Objective: To assess the specific non-motor symptoms of Parkinson disease (PD) at its early (preclinical) stages using the NMSQuest scale. Methods: The respondents were divided into 2 groups. The first (main) group included 43 patients with confirmed PD at the age of 51-79 years, on average 66.18±7.79 years. PD duration in the main group ranged from 7 to 28 years (12.65±4.86). The following forms of PD were identified: mixed form – 28 patients (65.1%), akinetic-rigid form – 9 patients (20.9%) and trembling form – 6 patients (13.9%). The second group (control) included 28 individuals without signs of neurodegenerative diseases, including PD, and other severe somatic pathologies. Their age ranged from 47 to 81 years (64.75±10.05). The following concomitant disorders (initial stages, compensated forms) were found in the patients of the 2nd group: arterial hypertension – in 13 patients (46.4%), diabetes mellitus – 9 patients (32.1%); osteoarthritis – 6 patients (21.4%). Results: Non-motor signs of PD, such as hypersalivation, decreased sense of smell, difficulty swallowing, memory impairment, constipation, increased sweating, difficulty walking and loss of self-confidence were significantly more often noticed in the main group, which indicated that they were typical for the patients with PD. It can be assumed that these symptoms could predict the development of PD during the latent and prodromal periods of the disease. Conclusion: Undoubtedly, the motor symptoms that occur in PD exert a significant negative affect on the lifestyle of patients. However, the non-motor symptoms of the disease should not be overlooked. Although many scientists associate the non-motor symptoms of PD with the aging process, our study showed that the use of screening scales confirmed their specificity for PD and correlation with its duration. At the same time, statistical analysis showed that a number of symptoms are characteristic only of PD, while the rest are associated with the natural aging process. Keywords: Parkinson disease, early stage, non-motor symptoms, screening scales, NMSQuest.
ALL THE NEW IS THE WELL FORGOTTEN OLD: AUTOPERICARDIAL MITRAL ANNULOPLASTY FOR DEGENERATIVE DEFECTS
Authors:   Specialized Cardiac Surgery Clinical Hospital named after Academician B.A. Korolyov, Nizhny Novgorod, Russian Federation, ZHURKO S.A. , GAMZAEV A.B. ,   Department of Endovascular Diagnostics and Treatment, Privolzhsky Research Medical University, Nizhny Novgorod, Russian Federation, AMINOV K.M. ,   Department of Endovascular Diagnostics and Treatment, Privolzhsky Research Medical University, Nizhny Novgorod, Russian Federation, PIMENOVA P.V. ,   Specialized Cardiac Surgery Clinical Hospital named after Academician B.A. Korolyov, Nizhny Novgorod, Russian Federation
Published: March 2023

Objective: To present the first-hand results of a modified mitral annuloplasty (MA) with an autopericardial strip (APS) in degenerative mitral valve disease (DMVD). Methods: Fifty-three patients with DMVD (mean age, 54.9±9.5 years (36-78 years); n=32 men (60.4%) and n=21women (39.6%)) undergoing MA with an APS, between January 2017 and January 2020 were retrospectively studied. In the overwhelming majority of cases, triangular and quadrangular resections of the P2 segment were performed. In addition, in some cases, neochords were implanted to the A2 segment. Intraoperatively, the result of MA was considered satisfactory if, according to transoesophageal echocardiography, the degree of mitral regurgitation (MR) did not exceed grade 1. Results: No in-hospital mortality was observed. One female patient had an early relapse caused by the rupture of one of the neochords at the A2 segment. However, the MR did not exceed grade 2, and the patient was actively followed up. Conclusion: Individual APS length selection avoids overcorrecting and achieves adequate systolic and diastolic mitral valve performance. Keywords: Annuloplasty, mitral regurgitation, autopericardium, mitral regurgitation.
ANALYSIS OF INCIDENCE AND MORTALITY OF GASTROINTESTINAL MALIGNANT TUMORS IN UKRAINE AND WORLDWIDE
Authors: Zub Valeriy
Published: March 2023

The aim of the research is to study the epidemiological situation of malignant tumors of the gastrointestinal tract in Ukraine and worldwide.

Material and Methods. The study was performed on the basis of data analysis of the National Cancer Registry of Ukraine during 2015-2019. Statistical methods, structural-logical analysis and system approach are used.

Results and Discussion. The research confirmed that mortality-to-incidence ratio for rectal MT in Ukraine is higher than worldwide, which indicates the need to primarily improve screening measures for colorectal cancer. Four nosological units (pancreas, stomach, pharynx, liver), characterized by extremely high level of neglected conditions, namely every third case among the first detected were identified. Based on the analysis of neglected cancer cases, trend equations were derived, which can be used to predict the degree of neglect of malignant tumors of the gastrointestinal tract. A study of one-year survival of patients showed that 40.1-45.5% patients with a newly diagnosed pharyngeal MT, 38.8-41% patients with MT of the oral cavity and 30.7-35% patients with MT of the colon do not survive for 1-year period from the moment of diagnosis. The most critical values of the rate of coverage of cancer patients with special treatment are typical for people with MT of the pancreas and MT of the liver: only one in four patients with MT of the pancreas and one in five patients with MT of the liver received special antitumor treatment within a year from the date of diagnosis.

Conclusions. Ensuring effective medical care for patients with malignant tumors remains a priority of the health care system of Ukraine. The solution to this problem lies at the intersection of the clinical part, economic, organizational and social planes.
A CASE REPORT OF CHRONIC PULMONARY THROMBOEMBOLISM AND ACCOMPANYING CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION: CHRONIC PULMONARY THROMBOEMBOLISM AND HYPERTENSION
Authors: Dogan Emrah , Tapan Ozge Oral , Tapan Utku , Olcay Sabri Serhan
Published: March 2023

Aim. Our paper aims to discuss the radiological and clinical findings of chronic pulmonary embolism (CPTE) and chronic thromboembolic pulmonary hypertension (CTEPH) over the patient's findings.

Material and Methods. We present the case of a 49-year-old female patient with CPTE and CTEPH.

Results and Discussion. CPTE is a long-term consequence of unresolved pulmonary embolism. Since pulmonary embolism's frequency dramatically increased during the COVID-19 pandemic, CPTE once again has become one of the current topics of scientific conversations. Radiology is a gold standard for diagnosis. CPTE is a complex pathology and multisystemic evaluation is essential.

Conclusions. Computed tomography (CT) findings can be classified into four groups: vascular, parenchymal, and systemic findings due to pulmonary hypertension and collateral formations. Changes in the ratio of right and left ventricle, size of the pulmonary artery, bowing sign and presence of mosaic attenuation should be directed us to the diagnosis of CTEPH in the patient with CPTE.
Usulan Perbaikan Desain Kemasan Produk Kiko Bakery Menggunakan Metode Quality Function Deployment (QFD)
Authors: Mahardika Nidya Shara , Agustina Suci
Published: March 2023

Kiko Bakery merupakan salah satu UMKM di Jawa Timur yang mengalami penurunan produksi di tahun 2021. Penyebab hal tersebut terjadi dikarenakan banyaknya pesaing bisnis yang muncul dan juga desain kemasan yang kurang menarik serta belum adanya keamasan sekunder yang layak untuk membungkus kemasan sehingga ditemukan banyak produk mengalami kerusakan karena masih dibungkus menggunakan kantung plastik. Peningkatan kualitas kemasan dapat menjadi jawaban dari permasalaan yang ada untuk menarik kembali minat konsumen dan menaikkan penjualan. Penelitian ini bertujuan untuk memberikan usulan perbaikan desain kemasan produk Kiko Bakery dengan mempertimbangkan keinginan konsumen. Analisis dilakukan menggunakan metode Quality Function Deployment (QFD) dengan beberapa tahapan mulai dari tahap pengumpulan voice of customer hingga tahap penetapan target dan benchmarking. Hasil dari analisis menyatakan bahwa kemasan produk kiko bakery belum memenuhi goal dari semua atribut whats dan beberapa atribut hows yang sudah ditetapkan. Usulan perbaikan yang dihasilkan adalah kemasan plastik jenis polipropilen ukuran 20 x 16 cm dengan isi satu buah, kemasan kardus jenis kertas ivory 250 gr/m2 ukuran 22 x 15 x 7 cm dengan isi dua buah roti, dan kemasan kardus besar jenis kertas ivory 310 gr/m2 ukuran 32 x 22 x 10 cm dengan isi 12 buah roti.
Analisis Customer Satisfaction Index (CSI) pada Cafe Mom Akar Pesanggaran Banyuwangi
Authors: Putri Mika Masarina , Satoto Eko Budi , Winahyu Pawestri
Published: March 2023

Pada era globalisasi ini persaingan bisnis sangat berkembang tajam baik itu mencakup pasar domestik maupun mancanegara.  Perusahaan membutuhkan strategi yang jitu untuk memenangkan persaingan dengan kompetitornya.  Salah satu dari strategi tersebut perusahaan mampu meningkatkan kepuasan pelanggan baik itu dari pembenahan kualitas produk, perbaikan layanan kepada pelanggan hingga pemberian harga yang sesuai dengan pelanggan. Dengan begitu loyalitas pelanggan kepada perusahaan dapat terjaga. Penelitian ini bertujuan mengetahui tingkat kepuasan pelanggan terhadap pelayanan service pada Café Mom Akar Pesanggaran Banyuwangi dan menentukan kriteria-kriteria yang menjadi prioritas perbaikan pelayanan dengan menggunakan metode Costumer Satisfaction Index (CSI). Dengan menggunakan metode Costumer Satisfaction Index (CSI), dapat diketahui prioritas pelayanan. Dari hasil penelitian yang telah dilakukan, diperoleh nilai index CSI 86,09%, yang menunjukan bahwa sebagian besar konsumen telah merasa sangat puas terhadap pelayanan yang diberikan, namun perusahaan harus lebih meningkatkan pelayanan.
STRATEGI KOMUNIKASI MEDIA SOSIAL INSTAGRAM INDOMARET DALAM MEMBANGUN BRAND AWARENESS
Authors: Pradana Wahyudiputra Rama Febriero , Setiawati Sri Dewi
Published: March 2023

PT. Indomarco Prismatama is one of the pioneers of retail in Indonesia, which was established in 1988. Since being franchised in 1997, it is a pioneer in the modern store retail franchise business. In 1997 Indomaret expanded its first franchise minimarket business in Indonesia after having more than 230 minimarket outlets. The purpose of this study is to determine the Brand Awareness built by PT. Indomarco Prismatama in terms of the purpose of doing Instagram social media account credibility, content management, and building interactions on Instagram social media accounts. This study uses a qualitative approach with case study methods on Instagram accounts of PT. Indomarco Prismatama to describe and explore the Brand Awareness phenomenon that occurred at PT. Indomarco Prismatama. This research was conducted by referring to the concepts and theories, namely The Circular Model of Some (Regina Lutrell, 2015), the Brand Awareness pyramid (Durianto, 2004). The conclusion of this study is that content management at PT. Indomarco Prismatama applies The Circular Model of Some in its content creation so that it can focus on the message, customer, and context. And also so that the content can provide benefits to the community.

Keywords: brand awareness, content management, Instagram, social media
PENGELOLAAN KONTEN MEDIA SOSIAL INSTAGRAM SEBAGAI STRATEGI DIGITAL MARKETING HOTEL DAFAM EXPRESS JAKSA JAKARTA
Authors: Diniati Anisa , Al Ghifari Muhammad Fahreza , Setiawati Sri Dewi , Sutarjo Moch. Armien Syifaa
Published: March 2023

Social media content has an important role in building relationships between institutions and their consumers. In the process of managing social media content, each institution has a specific target audience and objectives to determine the message to be conveyed. This study aims to find out how the management of Instagram social media content is used by Hotel Hotel Dafam Express Jaksa Jakarta as a Digital Marketing Strategy. digital marketing built to gain public trust. The method used is to use a qualitative approach with a descriptive research type. The results of the study show that the efforts to manage digital media content by DEJJ can be said to be quite active, even though the response from the audience is still lacking or not many have responded. The content uploaded is quite diverse, ranging from promo content, information on health protocols implemented in hotels, tutorials on using self-check-in machines, to commemorations of religious and national holidays. Instagram social media is also used by DEJJ to interact with the audience.

Keywords: content management, digital marketing, Instagram, social media
Evaluation of gingival health and pain level in orthodontics treatment with clear aligners: A systematic review and meta-analysis
Authors: Abusafia Bayan M. , Mohamed Abdelrahman M. A. , Al-Balaa Maher , Qiang Qiao Yi , Abbas Yousef S. , Yang Yan
Published: March 2023

Objectives:

The aim of the study was to assess the proficiency of clear aligners (CAs), and to evaluate all aspects of this orthodontic procedure including bleeding on probing (BOP), plaque index (PI), gingival index (GI), and probing pocket depth (PD), which all are clinical parameters of gingival inflammation in addition to the pain score.

Material and Methods:

We performed an electronic search in the different databases such as Cochrane CENTRAL for eligible studies, SCOPUS, PubMed, and Web of Science. The quality of the involved trials has been measured according to Cochrane’s risk of bias tool. The following outcomes have been assumed: BOP, PI, GI, probing PD, and pain score. The homogeneous and heterogeneous data have been evaluated using random-effects model and fixed-effects model, consistently.

Results:

Ten clinical trials have been included in the study. The pooled analysis that The CAs has been associated with a significant decrease in the pain score (standardized mean difference = 0.74 [0.46, 1.02]), (P = 0.0001). No significant variations between post-treatment and pre-treatment group were found regarding plaque index (mean difference [MD] = −0.11 [−0.45, 0.22]), (P = 0.5), BOP (MD = 0.20 [−0.01, 0.41]), (P = 0.06), GI (MD = 0.17 [−0.06, 0.40]), (P = 0.15), and BOP (MD = 0.01 [−0.16, 0.17]), (P = 0.94).

Conclusion:

Patients treated by CAs showed a noticeable decrease in pain scores. On contrary, there was not any difference between the pre-treatment data and post-treatment data regarding other indices.
Secure data transmission in geographically distributed information systems in ophthalmology based on domestic equipment
Authors:   The Bonch-Bruevich Saint Petersburg State University of Telecommunications, Saint Petersburg, Russian Federation, Ushakov I.A. , Dementiev R.I. ,   The Bonch-Bruevich Saint Petersburg State University of Telecommunications, Saint Petersburg, Russian Federation, Derzhko D.Y. ,   The Bonch-Bruevich Saint Petersburg State University of Telecommunications, Saint Petersburg, Russian Federation
Published: March 2023

Relevance. Currently, to ensure secure data transmission in geographically distributed information systems, including in ophthalmology, in particular secure data transmission of telemedicine consultations, when exchanging data between various healthcare institutions, when transmitting data during multicenter clinical trials, scientific developments, Multipoint Private Network (DMVPN) technology is widely used. DMVPN allows you to significantly reduce the load on equipment when organizing the work of remote offices. This «overlay» VPN reduces the participation of the provider in organizing a connection with a large number of users compared to analogues of the «peer-to-peer» type. Purpose. To evaluate the features of the transition to Eltex equipment when building a DMVPN in geographically distributed information systems in ophthalmology. Material and methods. Eltex ESR-200 routers were used as a laboratory stand. To measure the throughput of routers, the Iperf3 software product was used – a cross-platform console client-server program. Results. This article provides an assessment of the throughput of Eltex equipment when building secure DMVPN tunnels. Conclusion. Eltex equipment is productive and effective for solving the problems of building secure DMVPN tunnels to ensure secure data transmission in geographically distributed information systems in ophthalmology. Keywords: information security, performance, fault tolerance, DMVPN, IPsec, NHRP, routing, GRE tunnels
Neural network analysis of the visual system functional transformation in normal aging
Authors:   S. Fyodorov Eye Microsurgery Federal State Institution, Irkutsk Branch, Russian Federation, Rozanova O.I. , Mikhalevich I.M. ,   Irkutsk State Medical Academy of Postgraduate Education, branch of the Federal State Educational Institution APE RMANPE of the Ministry of Health of Russian Federation, Irkutsk, Russian Federation
Published: March 2023

Purpose. To reveal functional transformation patterns of the visual system in normal aging using neural network analysis. Material and methods. We examined 170 people aged 18 to 60 with objective refraction (under conditions of cycloplegia) from +5.5 D to –5.5 D. The criteria for selecting patients in the study groups were: maximally corrected visual acuity in the distance of each eye on a decimal scale of 1.0 and higher, normal color perception, absence of concomitant ophthalmopathology. A comprehensive assessment of the anatomical and optical eye parameters, indicators of monocular sensory reception and binocular interaction was carried out. 90 individual indicators of the visual system were used for neural network analysis with pattern recognition in a genetic algorithm with reduced dimensionality and step-by-step discriminant analysis. Results. Neural network analysis made it possible to establish the sequence of inclusion of 14 informative signs of the transformation of the visual system during normal aging. The contribution to the transformation of the visual system from changes in the accommodation system was 52%, from a decrease in the level of binocular interaction – 22%, changes in the function of the pupillary diaphragm – 13%, an increase in the temporal characteristics of sensory reception and signs of fatigue of the visual system – 11%. Conclusion. Neural network analysis allowed us to establish the sequence of inclusion of 14 informative signs of transformation of the visual system in normal aging. Normal aging of the visual system is expressed not only in a decrease in accommodative ability, but also in a decrease in the level of binocular interaction and binocular summation, in an increase in the processes of functional fatigue in the process of sensory reception, accompanied by a change in the function of the pupil. Keywords: normal aging, visual system, presbyopia, artificial neural network
Development of a cataract screening model using an open dataset and deep machine learning algorithms
Authors:   The S. Fyodorov Eye Microsurgery Federal State Institution, the Krasnodar Branch, Krasnodar, Russian Federation, Sakhnov S.N. , Axenov K.D. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Krasnodar Branch, Krasnodar, Russian Federation, Axenova L.E. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Krasnodar Branch, Krasnodar, Russian Federation,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Krasnodar Branch, Krasnodar, Russian Federation, Vronskaya V.V. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Krasnodar Branch, Krasnodar, Russian Federation, Martsinkevich A.O. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Krasnodar Branch, Krasnodar, Russian Federation, Myasnikova V.V. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Krasnodar Branch, Krasnodar, Russian Federation,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Krasnodar Branch, Krasnodar, Russian Federation
Published: March 2023

Relevance. Untreated cataract is the cause of permanent blindness. The main factors of untimely surgical treatment are the lack of patient's awareness about the need for surgical treatment (36.1%) and work or household employment (25.3%). Thus, regular cataract screening is an effective way to prevent blindness and identify patients in need of surgery. Purpose. Development of a cataract screening system based on an open data set, as well as its validation on clinical data. Material and methods. An open dataset (No. 1) of 9668 smartphone camera images, of which 4514 were cataracts and 5154 were normal eyes. The set for external validation (No. 2) was obtained under clinical conditions in the diagnostic department of the Krasnodar branch of the The S. Fyodorov Eye Microsurgery Federal State Institution. The set contained 51 cataract and normal images. To create a machine learning model, we used a convolutional neural network (CNN). Results. The data classification accuracy value was 0.97 for the internal validation set and 0.75 for the external one. The predictive value was low for cataract at the change in data set №2 and was only 0.54, as well as for sensitivity (0.87) and specificity (0.69) metrics. The area under the ROC curve was 0.99 (for dataset No. 1) and 0.78 (for dataset No. 2). Conclusion. These results indicate that it is necessary to fine-tune the model and provide the necessary levels of performance metrics for this scenario. Keywords: cataract, artificial intelligence, machine learning, screening, open datasets
Tackling Natural Hazards: A Scoping Evidence for Social Work Practice
Authors: . Guddo
Published: March 2023

The sudden onsets of hazards produce panic and stressful environments for individuals and the masses. They affect people's capacity to restore and maintain everyday functioning. They may experience severe physical and psychological injuries, property destruction, loss of livelihood, displacement and social problems during the disaster. However, the magnitude of disaster impact depends on the people's exposure, vulnerability type and population demography. These lethal situations, triggered by natural or man-made causes, need a multi-sectoral response to reduce the impact. Therefore, the narrative review method highlighted the scope of social work interventions in disaster management. Their assertive involvement in disaster response, recovery and rehabilitation can alter the possible outcomes. They should be engaged in every phase of disaster to perform versatile roles and responsibilities like conducting risk assessments, strengthening early warning systems, preparing an emergency plan, providing psycho-social interventions, facilitating the resettlement and rehabilitation process and policy and program formulation.
Synthesis and characterization of heterobinuclear Schiff base nickel(II) complexes involving nitrogen and oxygen donor ligand
Authors: Prakash Shivani , Gupta Anju K. , Prakash Sachin , Singh K.R.R.P. , Prakash D.
Published: March 2023

This study reports the synthesis of five novel Schiff base heterobinuclear nickel(II) and tin(II) complexes. The heterobinuclear complexes were synthesized by the interaction of N,N′-ethylenebis(2-hydroxyacetophenoniminato) nickel(II) with tin(II) salts of 2,4,6-trinitrophenol, 1-nitroso-2-naphthol, o-nitrophenol, 8-hydroxyquinoline and 2,4-dinitrophenol. Characterization of these complexes was carried by physico-chemical techniques such as elemental analyses, conductivity measurements, magnetic measurements, infrared spectra and electronic spectral studies. The molar conductance data reveals that the complexes are non-electrolytic in nature. The magnetic susceptibility data and the spectral studies propose square planar geometry of the complexes around nickel(II) and coordination to the metal centre via azomethine nitrogen and deprotonated phenolic oxygen atoms.
Kinetics Study of Hydrogen Combustion over Pt/Alumina Catalyst
Authors: Chauhan Vaishali , Chauhan Nishant
Published: March 2023

Combustion of hydrogen releases energy but in many applications, catalytic combustion of hydrogen may prove advantageous over direct combustion. The main advantage of catalytic combustion of hydrogen is that heat can be obtained at lower temperatures as well. The activity of catalyst for combustion of lean mixtures (< 2%) of hydrogen was studied in the present work and the kinetics of catalytic combustion of hydrogen has been established. The combustion of hydrogen on alumina supported platinum catalyst starts at above 323 K. Two reaction models have been investigated for possible mechanism of the reaction. The kinetics follows Hougan-Watson model where both hydrogen and oxygen adsorb on same site; hydrogen undergoes dissociative chemisorption and surface reaction being the slowest step. However, a simplified power law type rate equation was also established which adequately fits the experimental data for temperature between 373 and 673 K.
Effect of Condensation Product on the Electrochemical Behaviour and Corrosion Resistance of Zn and Zn-Ni Deposits
Authors: Patil Nagabhushana , Mamatha G.P. , Basavanna S.
Published: March 2023

Electrodeposition of Zn and Zn-Ni deposits were performed on steel substrates under various conditions from acid sulphate baths in presence of condensation product of 3, 4, 5-trimethoxybenzaldehyde and serine (TMBS). The electrochemical behavior of deposits was studied by polarization and electrochemical impedance techniques. The Zn-Ni-bright deposits obtained from the acid sulphate bath at 4 Adm-2 showed a lower corrosion current (Icorr) and a less negative corrosion potential (Ecorr) compared to Zn-dull, Zn-Ni-dull and Zn-bright deposits. The surface morphology and phase structure of the deposits was studied by Scanning electron microscopy (SEM) and X-ray diffraction (XRD) analysis.
Synthesis and cytotoxicity of Mannich Base of Benzimidazole Derivatives against Neuroblastoma Cell line
Authors: Vasuki B. , Mahadevan N. , Sekar V. , Vijayabaskaran M. , Senthil V.
Published: March 2023

The present study is to synthesize a novel Mannich base of benzimidazole derivatives and to screen for cytotoxicity in a neuroblastoma cell line using the MTT assay. 2-phenyl benzimidazole, formaldehyde, adamantine 1-carboxylicacid and substituted benzylamine such as 4-methyl, 4-methoxy, 4-chloro, 2-chloro, 4-fluoro, 3-methoxy, 4-trifluoromethyl, 3,4-dichloro and 3,5 bistrifluoromethyl were used to synthesize Mannich bases of (3r, 5r, 7r)-N-Benzyl-N-((2-phenyl-1H-benzo[d]imidazol-1-yl) methyl) adamantane-1-carboxamide. The MTT cell viability assay was performed to determine the half maximal inhibitory concentration (IC50) of synthesized compounds. Neuroblastoma (SK-N-MC) exposed to Mannich base at different concentration of 6.25 μg/mL, 12.5 μg/mL, 25 μg/mL, 50 μg/mL and 100 μg/mL was compared with standard drug. The IC50 value of the 4-methoxy Mannich base derivative was found to be 74.64 μg/mL. The IC50 values of benzylamine substituted Mannich base such as benzylamine, 4-methyl, 4-chloro, 2-chloro, 4-fluoro, 3-methoxy, 3,4-dichloro, 4-trifluoro methyl and 3,5 bistrifluoromethyl derivatives were found to be 35 μg/mL, 34.08 μg/mL, 27.29 μg/mL, 25.88 μg/mL, 33.11 μg/mL, 52.91 μg/mL, 44.80 μg/mL, 30.87 μg/mL and 55.20 μg/mL respectively. Among the electron withdrawing and electron donating substituents on Mannich bases, 2-chloro benzylamine substituted Mannich base possessed the highest cytotoxicity.
Research and development of the ESG agenda on the Russian market in the conditions of the world geopolitical situation
Authors: Degtyareva V. V. , Murzintseva D. A.
Published: March 2023

The object of this article is a study of the ESG agenda for Russian business in the changed geopolitical conditions. The statistical data used in the study were collected by the authors from open sources posted on the Internet and printed publications. The main purpose of the study was to identify ESG strategies of companies, their development, and to define key drivers of the development of the ESG agenda in Russia. During the research, the authors used general scientific methods such as synthesis, system and comparative analyses. The authors of the article identified the key drivers of the ESG concept development which will contribute to the growth of not only a single company, but also of the country’s economy as a whole. Based on the results of the study the authors have developed recommendations for the implementation of the ESG strategy in the current geopolitical circumstances.
Methods and tools of project management used in production organizations
Authors: Artamoshkina A. A. , Sycheva S. M. , Khalimon E. A.
Published: March 2023

Project management is an important part of all business processes, as the future of the enterprise depends on the success of the implementation of project activities. The article discusses the main methods of project management used in production organizations: Agile, Kanban, Waterfall and Scrum. The following general scientific research methods were used: analysis, generalization, classification, description. The purpose of the article is to popularize the application of the project approach in the manufacturing sector of the economy by systematizing the main methods of project management for their further use by companies. Examples of the methods application in Russian production organizations – JSC “Litmashdetal” and the publishing house “MIF” are presented. The main digital project management tools used in production and companies are demonstrated, with the help of which the effective implementation of the project approach is possible. Such an approach can be implemented in production if the principles of the method used are observed in the process of its realization in the company.
Stacks of a Hidden Treasure: on the Self-Assembly of Perovskite Nanoplates in Organic Solvents
Authors: Moral Raphael F. , Malfatti-Gasperini Antônio A. , Bonato Luiz G. , Vale Brener R. C. , Padilha Lázaro A. , Oliveira Cristiano L. P. , Nogueira Ana F.
Published: March 2023

In recent years, perovskite nanocrystal superlattices have been reported with collective optical phenomena, offering a promising platform for both fundamental science studies and device engineering. In this same avenue, superlattices of perovskite nanoplates can be easily prepared on different substrates, and they too present ensemble optical response. However, the self-assembly and optical properties of these aggregates in solvents have not been reported to date. Here, we report on the condition for this self-assembly to occur and show a simple strategy to induce the formation of these nanoplates stacks in suspension in different organic solvents. We combined wide- and small-angle X-ray scattering and scanning transmission electron microscopy to evaluate CsPbBr3 and CsPbI3 perovskite nanoplates with different thickness distributions. We observed the formation of these stacks by changing the concentration of nanoplates and the viscosity of the colloidal suspensions, without the need of antisolvent addition. We found that, in hexane, the concentration threshold for the formation of the stacks is rather high and approximately 80 mg/mL. In contrast, in decane, dodecane, and hexadecane, we observe a much easier self-assembly of the nanoplates, presenting a clear correlation between the degree of aggregation and viscosity. We, then, discuss the impact of the self-assembly of perovskite nanoplates on Förster resonant energy transfer. Our predictions suggest an energy transfer efficiency higher than 50%, even in a low photoluminescence quantum yield scenario, for both perovskite compositions.
Flue-to-Fuel: Biomediated carbon capture and utilization of dilute CO2 gas streams to biomethane
Authors: Sieborg Mads Ujarak , Ottosen Lars Ditlev Mørck , Kofoed Michael Vedel Wegener
Published: March 2023

Capturing anthropogenic carbon dioxide (CO2) and utilizing it as a feedstock for chemical production has been identified as an essential step towards mitigating climate change. The most dominant CO2 emissions originate from flue gases that contain diluted concentrations of CO2 emitted from combustion and industrial processes. Conventional capture technologies such as amine scrubbing are impeded by their high energy demand due to the thermodynamically low driving force for desorbing CO2. A new concept is here presented that exploits the robustness of microbial catalysts to simultaneously desorb the CO2 from an amine-based absorbent and convert the captured CO2 to biomethane (CH4) in a single step by the use of renewable hydrogen. The concept combines carbon capture with that of power-to-methane, to hereby abate CO2 emissions and use the captured CO2 as a resource. Experimental results of the conceptual design in batch reactors demonstrated high microbial biocompatibility with amine methyl diethanolamine (MDEA). The biocompatibility was examined in the range of 0 – 500 mM MDEA, and the system demonstrated almost full bioavailability of the absorbed CO2 until 120 mM of MDEA. Within this range, the CH4 productivity ranged from 40.7 - 63.6 NmLCH4 L-1culture h-1 from synthetically absorbed CO2 with a maximum conversion 1.77 times higher than traditional biomethanation with gaseous CO2. Conversion of raw flue gas from a biogas engine resulted in only a slight decrease in conversion efficiency compared to that of pure gasses, which demonstrated that the concept has high robustness to the impurities and oxygen present in raw flue gas.
Evaluation of Data Dependent MS/MS Acquisition Parameters for Non-targeted Metabolomics and Molecular Networking of Environmental Samples - Focus on the Q Exactive Platform
Authors: Stincone Paolo , Pakkir Shah Abzer K. , Schmid Robin , Graves Lana , P. Lambidis Stilianos , Torres Ralph , Xia Shu-Ning , Minda Vidit , Aron Allegra , Wang Mingxun , Hughes Chambers C. , Petras Daniel
Published: March 2023

Non-targeted liquid chromatography tandem mass spectrometry (LC-MS/MS) is a widely used tool for the detection and annotation of small molecules in complex environmental samples. Data Dependent Acquisition (DDA) of product ion spectra is thereby currently one of the most frequently applied data acquisition strategies. The optimization of DDA parameters is central to ensuring high spectral quality, coverage and number of compound annotations. Here, we evaluated the influence of 10 central DDA settings of the Q Exactive mass spectrometer on natural organic matter samples from ocean, river, and soil environments. After data analysis with Classical and Feature-based Molecular Networking using MZmine and GNPS, we compared the total number of network nodes, multivariate clustering, and spectrum quality related metrics such as annotation and singleton rates, MS/MS placement and coverage. Our results show that Automatic Gain Control, Microscans, Mass Resolution, and Dynamic Exclusion are the most critical parameters, whereas Collision Energy, TopN, and Isolation Width had moderate and Apex Trigger, Monoisotopic Selection, and Isotopic Exclusion minor effects. The insights into the data acquisition ergonomics of the Orbitrap platform presented here can guide new users and provide them with initial method parameters, some of which may also be transferable to other sample types and MS platforms.
Mitochondrial dysfunction rapidly modulates the abundance and thermal stability of cellular proteins
Authors: Groh Carina , Haberkant Per , Stein Frank , Filbeck Sebastian , Pfeffer Stefan , Savitski Mikhail M , Boos Felix , Herrmann Johannes M
Published: March 2023

Cellular functionality relies on a well-balanced, but highly dynamic proteome. Dysfunction of mitochondrial protein import leads to the cytosolic accumulation of mitochondrial precursor proteins which compromise cellular proteostasis and trigger a mitoprotein-induced stress response. To dissect the effects of mitochondrial dysfunction on the cellular proteome as a whole, we developed pre-post thermal proteome profiling. This multiplexed time-resolved proteome-wide thermal stability profiling approach with isobaric peptide tags in combination with a pulsed SILAC labelling elucidated dynamic proteostasis changes in several dimensions: In addition to adaptations in protein abundance, we observed rapid modulations of the thermal stability of individual cellular proteins. Different functional groups of proteins showed characteristic response patterns and reacted with group-specific kinetics, allowing the identification of functional modules that are relevant for mitoprotein-induced stress. Thus, our new pre-post thermal proteome profiling approach uncovered a complex response network that orchestrates proteome homeostasis in eukaryotic cells by time-controlled adaptations of the abundance and the conformation of proteins.
Polar Navigator Ivan Tolstoukhov
Authors:   Scientific and Production Association “Archaeological Design and Survey”, Barakhovich P. N. ,   Autonomous Non-Profit Organization “Archaeological Research of Siberia”
Published: March 2023

The article discusses such a little-known episode of the development of the Arctic as the voyage of Ivan Tolstoukhov and his comrades from Novaya Mangazeya to the mouth of the Pyasina River in order to go around the Taimyr (to pass the most difficult part of the Northern Sea Route). The circumstances of the campaign are poorly investigated and almost nothing is known about the identity of the navigator. Also in historiography, there are different opinions about the path of Tolstoukhov and his comrades (in particular, M. I. Belov believed that they managed to bypass Taimyr by sea). Therefore, in order to establish the route of the explorer and reconstruct his family ties, the article studied a significant body of documentary sources that were not introduced into scientific circulation, stored in the RSNA (St. Petersburg) and RSAA (Moscow). The work establishes that Ivan Tolstoukhov was able to swim to the lower reaches of the Pyasina and, after an unsuccessful attempt to go around Taimyr, died in the Yenisei Bay on the way back. In addition, the article puts forward a hypothesis about the connection of the navigator with the wealthy trading family of the Turukhansk Tolstoukhovs, who originated from the settlement of Veliky Ustyug.
Yakut Merchants of the 1st Guild P. A. Kushnarev and G. V. Nikiforov: National Achievements in the Historical Context
Authors:   Irkutsk State University, Kushnareva M. D.
Published: March 2023

The main purpose of the publication is to analyze the main achievements of the Yakut merchants of the 1st guild – P. A. Kushnarev and G. V. Nikiforov in the business and public spheres during the period of modernization of the Russian economy. It is noted that the study of the mission of the national merchants is relevant and scientifically significant. The problem of the succession of capital, the interaction of large entrepreneurs in economic activity is touched upon.
Absenteeism of Russian Nationalism in the Context of Philosophical Discourse
Authors: Bobkov A. I. , Ageev A. V.
Published: March 2023

The assertion of the absenteeism of Russian nationalism is a factor of ignoring its potential as an ideology of consolidation of Russian society. The reason for this disregard lies in the prolongation of the uprising of the masses and the absolutization of the end of the social. Because nationalism is one of the founding principles of modernity and post-modernity, the crowd-elite model of social consolidation management seeks to replace it with a simulacrum of quasi-nationalism. Otherwise, the end of the social will be replaced by the end of the masses, which means that the realization of the emptiness of an individualized society will come. Moreover, in the conditions of overcoming the absenteeism of nationalism in Russia, the consolidation of the traditional subject of the people with the modernist subject of the nation and the postmodern subject of integrated individuality can finally take place.
HEALTH AND LIFE EXPECTANCY IN BURYATIA IN MODERN CONDITIONS
Authors:   Dorzhi Banzarov Buryat State University, Osinsky I. I.
Published: March 2023

Health is one of the most important values of society. With the transition to market relations in Buryatia, the problems of protecting the health of the population have become more complicated, the level of morbidity and mortality has increased, which is associated with the low standard of living of a significant part of its inhabitants, and the shortage of medical personnel, especially in rural areas. The republic has a low average standard of living. Some positive developments that have recently emerged give hope for improving the health of the population, increasing the duration of a healthy lifestyle.
Research on the Cultivation of Craftsmanship in Huang Yanpei’s Education Thought
Authors: Wang Shang , Peng Fei , Qiu Jie
Published: March 2023

Skilled talents are the main support for the strategic development of science and technology in China. The quality of talents is an important guarantee for the transformation and upgrading of national industries. By analyzing and studying Huang Yanpei’s thought on vocational education, this paper focuses on the cultivation of students’ craftsmanship in vocational schools. First, we analyze the results of previous research and then elaborate on the connotations of Huang Yanpei’s education thought and craftsmanship spirit. Lastly, we propose five suggestions for the cultivation of craftsmanship. Our research work carries certain reference value to the study of craftsmanship cultivation in Huang Yanpei’s education thought.
The Effect of Water Concentration on Growth Media on Lipid Production by Oleaginous Fungi Isolate BR 2.2
Authors: Lesti Herin Yoga , Ilmi Miftahul
Published: March 2023

Oleaginous fungi are one of the microorganisms that can accumulate a high number of biomasses quickly (within 96-130 hours) and are often used to produce lipids. The growth of fungi depends on the chemical composition of the environment in which it grows. The growth media of fungi must contain high carbohydrates as a source of nutrients and high nitrogen content. One of the carbon sources that fungi can use in the growth process is glucose. BR 2.2 isolate is an oleaginous fungus capable of accumulating 28.44% lipids from the total dry biomass with glucose as a carbon source in 50 mL of growth media. Therefore, this study was conducted to determine the effect of variations in the volume of media and incubation time on the production of biomass and lipid isolate BR 2.2. Biomass and lipid production were analyzed at media with additional water volumes of 10, 20, 30, 40, and 50 mL with 48, 96, and 144 hours of incubation times. The results showed that lipid accumulation and biomass production increased with the reduction of water content in the growth media and reached the highest number in the media volume of 20 mL with an incubation time of 144 hours, i.e., 0.87±0.04 g/L and 12.53±0.29 g/L. It can be concluded that biomass and fungal lipid increased along with incubation time and nutrient concentration.
Identification and Characterization of a Novel Bacterial Species Found in the Lebanese Soil. (c2022)
Authors:   ,   Lebanese American University, Kyprianos Shirine
Published: March 2023

The disruption of the soil's ecosystem causes a disturbance in microbial communities and leads to the emergence of dangerous resistant pathogens and most antibiotic resistance genes. An unknown bacterial strain was collected from a mushroom compost in the Lebanese soil as part of another project aiming to identify bacteria capable of being used in bio-cementation. Our study aims to identify and characterize the unknown strain, its features, behavior, and infectious potential. Standardized techniques were used to determine the morphology and staining properties of the bacteria, biochemical and physiological reactions, and susceptibility and resistance to different antimicrobial agents. Since the strain originated from a mushroom compost in the soil, potassium hydroxide ruled out fungal entities. The bacteria are Gram-negative, rod-shaped, obligate aerobes, non-spore forming and non-encapsulated, urease, coagulase, and catalase-positive, oxidase-negative, possessing β-hemolytic activity, and resistant to UV light. The bacterial strain did not form biofilms at the air liquid interface and produced calcium carbonate precipitates. Antimicrobial susceptibility tests were carried out using antibiotics of major classes and Cannabidiol (CBD) oil. The strain conferred resistance to azithromycin, doxycycline, and trimethoprim-sulfamethoxazole. CBD demonstrated bactericidal activity at low doses but did not have an effect at higher concentrations. Based on the results obtained, we determined that the strain belonged to the genus Gluconacetobacter. All in all, these findings provide preliminary results related to the potential virulence of the bacterial species and its resistance to different antimicrobials. Future in vivo studies are required to determine the infectivity spectrum of the bacteria. Whole genome sequencing is also essential to detect and analyze resistance genes, virulence factors, and clusters for the production of bio-cement.