bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of a Streamlined Oncologist-Led BRCA Mutation Testing and Counseling Model for Patients With Ovarian Cancer
Authors: Colombo Nicoletta , Huang Gloria , Scambia Giovanni , Chalas Eva , Pignata Sandro , Fiorica James , Van Le Linda , Ghamande Sharad , González-Santiago Santiago , Bover Isabel , Graña Suárez Begoña , Green Andrew , Huot-Marchand Philippe , Bourhis Yann , Karve Sudeep , Blakeley Christopher
Published: March 2018

Purpose

There is a growing demand for BRCA1/ 2 mutation ( BRCAm) testing in patients with ovarian cancer; however, the limited number of genetic counselors presents a potential barrier. To facilitate more widespread BRCAm testing in ovarian cancer, pretest counseling by the oncology team could shorten testing turnaround times and ease the pressure on genetic counselors.

Patients and Methods

The prospective, observational Evaluating a Streamlined Onco-genetic BRCA Testing and Counseling Model Among Patients With Ovarian Cancer (ENGAGE) study evaluated a streamlined, oncologist-led BRCAm testing pathway. The analysis population comprised 700 patients with ovarian cancer at 26 sites in the United States, Italy, and Spain. The primary objectives were to assess turnaround time and, using questionnaires, to evaluate stakeholder satisfaction (patients, oncologists, and geneticists or genetic counselors) with the oncologist-led BRCAm testing pathway.

Results

The median overall turnaround time was 9.1 weeks (range, 0.9 to 37.1 weeks), with median turnaround times in the United States, Italy, and Spain of 4.1 weeks (range, 0.9 to 37.1 weeks), 20.4 weeks (range, 2.9 to 35.4 weeks), and 12.0 weeks (range, 2.0 to 36.7 weeks), respectively. Patient satisfaction with the oncologist-led BRCAm testing pathway was high, with > 99% of patients expressing satisfaction with pre- and post- BRCAm test counseling. Oncologist satisfaction with the BRCAm testing pathway was also high, with > 80% agreeing that the process for performing BRCAm testing worked well and that counseling patients on BRCAm testing was an efficient use of their time. Oncologists expressed higher levels of satisfaction with the BRCAm testing pathway than did geneticists or genetic counselors.

Conclusion

The results of the ENGAGE study demonstrate that an oncologist-led BRCAm testing process is feasible in ovarian cancer. Development of local BRCAm testing guidelines similar to the one used in this study could allow faster treatment decisions and better use of resources in the management of patients with ovarian cancer.
Concurrent Veliparib With Chest Wall and Nodal Radiotherapy in Patients With Inflammatory or Locoregionally Recurrent Breast Cancer: The TBCRC 024 Phase I Multicenter Study
Authors: Jagsi Reshma , Griffith Kent A. , Bellon Jennifer R. , Woodward Wendy A. , Horton Janet K. , Ho Alice , Feng Felix Y. , Speers Corey , Overmoyer Beth , Sabel Michael , Schott Anne F. , Pierce Lori ,   for the Translational Breast Cancer Research Consortium
Published: March 2018

Purpose

Locoregional control for inflammatory breast cancers and chest wall recurrences is suboptimal, which has motivated interest in radiosensitization to intensify therapy. Preclinical studies have suggested a favorable therapeutic index when poly (ADP-ribose) polymerase inhibitors are used as radiosensitizers; clinical investigation is necessary to establish appropriate dosing and confirm safety.

Patients and Methods

We conducted a multi-institutional phase I study of veliparib and concurrent radiotherapy (RT) to the chest wall and regional lymph nodes in 30 patients with inflammatory or locally recurrent breast cancer after complete surgical resection. RT consisted of 50 Gy to the chest wall and regional lymph nodes plus a 10-Gy boost. A Bayesian time-to-event continual reassessment method escalated dose through four levels, with a 30% targeted rate of dose-limiting toxicity (DLT) measured during the 6 weeks of treatment plus 4 weeks of follow-up. DLTs were defined as confluent moist desquamation > 100 cm2, nonhematologic toxicity grade ≥ 3, toxicity that requires an RT dose delay > 1 week, absolute neutrophil count < 1,000/mm3, platelet count < 50,000/mm3, or hemoglobin < 8.0 g/dL if possibly, probably, or definitely related to study treatment.

Results

Five DLTs occurred: Four were moist desquamation (two each at 100 and 150 mg twice a day), and one was neutropenia (at 200 mg twice a day). The crude rate of any grade 3 toxicity (regardless of attribution) was 10% at year 1, 16.7% at year 2, and 46.7% at year 3. At year 3, six of 15 surviving patients had severe fibrosis in the treatment field.

Conclusion

Although severe acute toxicity did not exceed 30% even at the highest tested dose, nearly half of surviving patients demonstrated grade 3 adverse events at 3 years, which underscores the importance of long-term monitoring of toxicity in trials of radiosensitizing agents.
Hsp70–Hsp110 chaperones deliver ubiquitin-dependent and -independent substrates to the 26S proteasome for proteolysis in yeast
Authors: Kandasamy Ganapathi , Andréasson Claes
Published: March 2018

During protein quality control, proteotoxic misfolded proteins are recognized by molecular chaperones, ubiquitylated by dedicated quality control ligases and delivered to the 26S proteasome for degradation. Proteins belonging to the Hsp70 chaperone and Hsp110 (the Hsp70 nucleotide exchange factor) families function in the degradation of misfolded proteins by the ubiquitin-proteasome system via poorly understood mechanisms. Here, we report that the Saccharomyces cerevisiae Hsp110 proteins (Sse1 and Sse2) function in the degradation of Hsp70-associated ubiquitin conjugates at the post-ubiquitylation step and are also required for ubiquitin-independent proteasomal degradation. Hsp110 associates with the 19S regulatory particle of the 26S proteasome and interacts with Hsp70 to facilitate the delivery of Hsp70 substrates for proteasomal degradation. By using a highly defined ubiquitin-independent proteasome substrate, we show that the mere introduction of a single Hsp70-binding site renders its degradation dependent on Hsp110. The findings define a dedicated and chaperone-dependent pathway for the efficient shuttling of cellular proteins to the proteasome with profound implications for understanding protein quality control and cellular stress management.
Defining Success in Open Science
Authors: Ali-Khan Sarah E. , Jean Antoine , MacDonald Emily , Gold E. Richard
Published: March 2018

Mounting evidence indicates that worldwide, innovation systems are increasing unsustainable. Equally, concerns about inequities in the science and innovation process, and in access to its benefits, continue. Against a backdrop of growing health, economic and scientific challenges global stakeholders are urgently seeking to spur innovation and maximize the just distribution of benefits for all. Open Science collaboration (OS) – comprising a variety of approaches to increase open, public, and rapid mobilization of scientific knowledge – is seen to be one of the most promising ways forward. Yet, many decision-makers hesitate to construct policy to support the adoption and implementation of OS without access to substantive, clear and reliable evidence. In October 2017, international thought-leaders gathered at an Open Science Leadership Forum in the Washington DC offices of the Bill and Melinda Gates Foundation to share their views on what successful Open Science looks like. Delegates from developed and developing nations, national governments, science agencies and funding bodies, philanthropy, researchers, patient organizations and the biotechnology, pharma and artificial intelligence (AI) industries discussed the outcomes that would rally them to invest in OS, as well as wider issues of policy and implementation. This first of two reports, summarizes delegates' views on what they believe OS will deliver in terms of research, innovation and social impact in the life sciences. Through open and collaborative process over the next months, we will translate these success outcomes into a toolkit of quantitative and qualitative indicators to assess when, where and how open science collaborations best advance research, innovation and social benefit. Ultimately, this work aims to develop and openly share tools to allow stakeholders to evaluate and re-invent their innovation ecosystems, to maximize value for the global public and patients, and address long-standing questions about the mechanics of innovation.
FORMATION OF THE MODEL OF DESIGNING THE SYSTEM "ROAD CONDITIONS - TRANSPORT FLOWS" AND WAYS OF ITS IMPLEMENTATION
Authors: Козлов Вячеслав , Kozlov Vyacheslav , Скрыпников Алексей , Skrypnikov Aleksey , Микова Елена , Mikova Elena , Могутнов Роман , Mogutnov Roman , Чирков Евгений , Chirkov E.
Published: March 2018

A model for managing the system "road conditions - traffic flows" is proposed that allows to ensure the functioning of the complex "driver - car - road - environment" in any weather and climate conditions. The analysis of the proposed model and target functional shows that optimization of the "road conditions - traffic flow" system can proceed in many directions, the main of which are: optimal development and placement of the network of forest roads, improving their technical level and level of maintenance, road engineering equipment , efficient traffic management, excluding the rational distribution of forest traffic on the network of forest roads and the management modes on individual logging roads and sections of forest roads. The developed model makes it possible to carry out a theoretical analysis and experimental verification of the interaction between «driver-car-road-environment" system in order to identify the reserves of increasing efficiency of its operation and purposeful management of this process. Transport-operational characteristics of logging roads are the main factors that shape the conditions of timber transport on the road, mode, convenience and safety of traffic and determine the efficiency of road transport, and connections of many characteristics of roads with the traffic modes have deterministic, corrective character. These patterns are the basis for the development of technical requirements for logging roads. The proposed model for integrated creation and management of the functioning of a forest road may already be implemented. However, the design of roads is expedient to provide complex control engineering and organizational measures to ensure the estimated traffic conditions during the whole period of operation of the road, regardless of the time of year and weather and climate conditions. Evaluation of the effectiveness of taken decisions should be made with mandatory consideration for ensuring the required performance of logging road in adverse periods of the year and in difficult weather conditions
THEORETICAL FOUNDATIONS OF OBTAINING MODIFIED WOOD
Authors: Курьянова Татьяна , Kuryanova Tatyana , Платонов Алексей , Platonov Aleksey , Михеевская Марина , Mikheevskaya Marina , Снегирева Светлана , Snegireva Svetlana , Первакова Е. , Pervakova E.
Published: March 2018

The element of the upper structure of the railway track are sleepers, which are made mainly of wood. Wooden sleepers from natural wood have a number of disadvantages. Reduce the disadvantages of sleepers made of natural wood is possible if their manufacture to use modified wood myag-kih hardwood, which by pressing will exceed the strength of the sleepers made of natural Dre-spring and its physical and mechanical characteristics is not inferior to the sleepers made of natural coniferous wood. However, one of the disadvantages of modified wood is its ability to change the size and shape with increasing humidity. Therefore, there is a need to create a new high-tech re-surdobarokamere the production of railway sleepers of the modified wood with improved ex-operational characteristics (durability, bio-logical stability, dimensional stability, wear resistance), exceeding the existing production. To increase the service life of wooden sleepers, increase their biostability and dimensional stability, raw materials for the production of sleepers must be impregnated with the composition of antiseptic and stabilizer, i.e. to conduct thermomechanical modification of wood. As raw materials it is possible to use wood of soft deciduous breeds of a birch and an aspen. Depending on the degree of pressing the sleepers of these species will exceed the strength of the sleepers of pine wood. But at the same time all properties of wood remain (damper, dielectric and others). Development of wood modification technology is possible on the basis of analysis of physical phenomena underlying technological operations. With this purpose, the theoretically calculated curves of heating of the billet in the section of the oily liquid, made on the basis of similarity criteria and on the basis of the physical phenomena of heat and mass transfer calculated duration of drying preparations. Accepted methods of impregnation, loading and relieving of the pressure during compaction
ABOUT THE CONDITION AND FIRE-FIGHTING MEASURES OF PROTECTION IN THE BRYANSK FORESTRY
Authors: Ковалев Борис , Kovalev Boris , Сакович Наталия , Sakovich Nataliya , Христофоров Евгений , Khristoforov Evgeniy , Баранов Юрий , Baranov Yu.
Published: March 2018

Bryansk forestry is located in the north-east of the Bryansk region, in the territories of the Bryansk and Karachev administrative districts, with a total area of 62,339 hectares, including 59,219 hectares of forest, and 16593 ha of forest cultures. Forests of the forest range are classified as protective, they are used in recreational, water-protective, environmental-forming purposes, grow on sands, moraines, sandy loam, loam. Forest management in the Bryansk forestry is aimed at rational forest management and management, enhancement of the forest resource potential, protection and protection of forests, expansion and rational use of forests through the systematic implementation of a set of forest management measures, growing forests to meet the needs of the Bryansk region in wood. The climatic conditions in the area of Bryansk forestry are mainly favorable for forest-forming coniferous and deciduous species. However, in recent years, dry periods of different duration and intensity have regularly occurred, which create conditions for the occurrence of fires. Research indicators that for the period from 2003 to 2015 in the territory of the forestry there were 2039 fires, a total area of 4,499.9 hectares. Only in 2014, the damage from forest fires amounted to 17434.2 thousand rubles, while directly to extinguish fires spent 1,434.2 thousand rubles. In 2015, the main causes of fires are: the human factor - 66 fires; grass fires - 27 fires; through the fault of the railway -10; other reasons - 3 fires and others. Elimination of forest fires in the forestry is carried out by land means, while the artificial and natural fire barriers created in advance, in particular, created with the help of a tractor, aggregated by the device for laying and reconstructing mineralized strips, and fire-fighting mineralized strips, are of great help in eliminating fires. In order to improve the microclimate in the tractor cab, the authors propose to use a control pedal with a hermetic terminal. Timely detection of fire and liquidation of a fire, reduces economic, natural, technological and social damage
USE OF TECHNOGENIC SANDS IN PRODUCTION OF CONCRETE
Authors: Крамаренко Аркадий , Kramarenko Arkady , Красильникова Оксана , Krasilnikova Oksana
Published: March 2018

In this article the analysis of concrete on the eliminations of subdivision of carbonaceous breeds (ESCB) is carried out. The comparative analysis of exemplars of concrete with various shallow filler and their main physics and technology properties is carried out. The most expedient structure for the subsequent use in construction is chosen
Discussões bioéticas em pesquisa envolvendo seres humanos: problematizações a partir das perspectivas normativas
Authors: Corrêa Bruna Bottero , Brauner Maria Claudia Crespo
Published: March 2018

A tendência normativa direcionada à bioética pode vir a retirar direitos consolidados pelas resoluções até então vigentes no Brasil. Diante disso, os Comitês de Ética em Pesquisa podem exercer papel fundamental na preservação da bioética, por serem órgãos que permitem a prática democrática preservando a dinâmica necessária aos requisitos em pesquisa em detrimento da comumente rigidez legislativa. No entanto, alguns fatores são importantes como a não existência de conflito de interesses e a responsabilização institucional a partir da vinculação desses órgãos ao sistema nacional. Apesar da manutenção desses fatores, algumas tendências em propostas legislativas pretendem flexibilizar essas exigências colocando em risco as garantias asseguradas pela longa trajetória de entendimento da bioética no país, além do próprio fluxo democrático deslocado para uma aparente ampliação da autonomia. O objetivo do presente artigo é realizar um breve estudo comparado entre as resoluções de 196/96 e 466/12 do Conselho Nacional de Saúde Brasileiro e da síntese comparativa analisar o projeto de lei nº 200 proposto pelo Senado Federal que trata da pesquisa clínica, a fim de identificar as alterações mais problemáticas envolvendo participantes e o sistema nacional de controle das pesquisas. A metodologia adotada é a análise bibliográfica. Justifica-se a importância da perspectiva adotada para a abordagem do tema bioética por se entender relevante para o mundo jurídico compreender a relação existente entre a problemática regulamentação da pesquisa e os interesses da sociedade. Igualmente, não foram encontrados trabalhos problematizando os direitos garantidos aos participantes e a importância dos CEPs, através da análise comparativa.
Violências às pessoas em situação de rua: o direito fundamental à segurança em xeque
Authors: Cabral Júnior Luciano Roberto Gulart , Costa Eder Dion De Paula
Published: March 2018

Objetiva-se neste artigo analisar as violências que acometem as pessoas em situação de rua e sua relação com o direito fundamental à segurança. Inicialmente, abordar-se-á a fragilidade social que afeta as pessoas em situação de rua, de modo a esboçar um panorama das idiossincrasias que lhes são atinentes. Em seguida, dialogar-se-á entre as modalidades de violências que atingem a população em situação de rua e o direito fundamental à segurança. A problemática projeta como o direito fundamental à segurança é, de fato, essencial no combate às violências para se trilhar rumo a garantir às pessoas em situação de rua, em última instância, a dignidade humana, fundamento da República Federativa do Brasil. Nesse contexto que se realiza a presente pesquisa qualitativa, através do método de abordagem dedutivo e do método de procedimento monográfico, com base na bibliografia e no conteúdo legislativo sobre o tema.
Resgate Histórico da Praça Dr. Salatiel: o Jardim do Largo da Cachaça, São João del-Rei, Minas Gerais, Brasil
Authors: Teixeira Amanda Burgarelli , Andrade Nayhara Camila , Alves Schirley Fátima Nogueira da Silva Cavalcante
Published: March 2018

The Dr. Salatiel Square, located at Marechal Bittencourt Street in the historical center of the São João del-Rei city, Minas Gerais State, Brazil, appeared in the twentieth century during the period of hygienism. It was inserted in a place that over the years suffered several modifications on its morphology. The work aims to study the landscape aspects and socio-cultural evolution of this square. This work execution consisted of the two steps: field research for the identification of the historical square significance, and a research that was carried out in the historical collections of the city. During the field research, it was collected the current state of Dr. Salatiel Square as well as its uses and potentials, and its botanical composition. Analyzing the square and its surroundings, and also the information collected in São João del-Rei, Minas Gerais State, Brazil, it was possible to verify that the site, which nowadays the Dr. Salatiel Square is placed, was occupied before by European influenced houses that were overthrown later in the period of hygienism. Among all the nomenclatures already attributed to the street that shelter the square, the best known by population is Cachaça’s Street due to the commerce of the time which favored the nightlife and bohemia. The square in study is part of the historical center of the city, and all its surroundings are overturned. However, the square has faced significant constructive and botanical modifications on its structure constituting a space characterized by the abandonment due to factors such as accumulation of garbage and great flow of vehicles. From the carried out study, it was verified that the number of information about the place is scarce, so that the continuation of its historical rescue is of great importance for means of preserving the history of the city and the population.
Kontroversi Pemikiran Teks Keagamaan Kiai Abdul Mu'thi, Pondok Pesantren An-Najah, Magelang
Authors: Yuwono Dandung Budi
Published: March 2018

This article discusses the thoughts of Kiai Mu'thi religious texts that have sparked controversy and internal conflicts among the NU as a critical discourse. Data collection is done by interview, observation, and documentation. The result of the research indicates that the problem of 73 classes (firqah) is a material that is never left behind in every Kiai Mu'thi recitation, as well as a commitment to always remind to fellow Muslims, especially the nahdliyin group which he calls the alignment of aqidah and amar ma'ruf nahi munkar. Da'wah movement is more oriented towards kiai, ulama, religious leaders, and religious teachers so that they can return in the direction that has been considered heretical. Kiai Mu'thi da'wah movement is a deconstruction as well as a reconstruction of discourse construction that develops among nahdliyin, and which is also a representation of the outward effort of the dominant pesantren hegemony in its territory in order to form entities and social relations.
NearSense – Advances Towards a Silicon-Based Terahertz Near-Field Imaging Sensor for Ex Vivo Breast Tumour Identification
Authors: Mavarani Laven , Hillger Philipp , Bücher Thomas , Grzyb Janusz , Pfeiffer Ullrich R. , Cassar Quentin , Al-Ibadi Amel , Zimmer Thomas , Guillet Jean-Paul , Mounaix Patrick , MacGrogan Gaëtan
Published: March 2018

Breast Cancer is one of the most frequently diagnosed cancer diseases worldwide, and the most common invasive tumour for women. As with all cancers, early detection plays a major role in reducing the mortality and morbidity rate. Currently, most breast cancers are detected due to clinical symptoms, or by screening mammography. The limitations of these techniques have resulted in research of alternative methods for imaging and detecting breast cancer. Apart from this, it is essential to define precise tumour margins during breast-conserving surgeries to reduce the re-excision rate. This study presents the advances in the development of a silicon-based THz sub-wavelength imager usable in life science applications, especially for tumour margin identification.
Identification of the Cause of the Stem Neck Fracture in the Hip Joint Endoprosthesis
Authors: Ryniewicz A.M. , Bojko Ł. , Ryniewicz A. , Pałka P. , Ryniewicz W.
Published: March 2018

Endoprosthesis stem fractures are among the rarest complications that occur after hip joint arthroplasty. The aim of this paper is to evaluate the causes of the fractures of the Aura II stem neck, which is an element of an endoprosthesis implanted in a patient. In order to achieve it, a radiogram was evaluated, the FEM analysis was carried out for the hip joint replaced using the Aura II prosthesis and scanning tests as well as a chemical analysis were performed for the focus of fatigue. The tests performed indicate that the most probable causes leading to the fatigue fracture of the Aura II stem under examination were material defects in the process of casting and forging (forging the material with delamination and the presence of brittle oxides and carbides) that resulted in a significant reduction of strength and resistance to corrosion. In the light of an unprecedented stem neck fracture, this information should be an indication for non-destructive tests of ready-made stems aiming to discover the material and technological defects that may arise in the process of casting and drop forging.
Selected Aspects of Cryogenic Tank Fatigue Calculations for Offshore Application
Authors: Skrzypacz J. , Jaszak P.
Published: March 2018

The paper presents the way of the fatigue life calculation of a cryogenic tank dedicated for the carriers ship application. The independent tank type C was taken into consideration. The calculation took into account a vast range of the load spectrum resulting in the ship accelerations. The stress at the most critical point of the tank was determined by means of the finite element method. The computation methods and codes used in the design of the LNG tank were presented. The number of fatigue cycles was determined by means of S-N curve. The cumulated linear damage theory was used to determine life factor.
A Robust Algorithm for Nonlinear Variable-Order Fractional Control Systems with Delay
Authors: António Tenreiro Machado José , Parsa Moghaddam Behrouz
Published: March 2018

In this paper, we propose a high-accuracy linear B-spline finite-difference approximation for variable-order (VO) derivative. We consider VO fractional differentiation as a control parameter for improving the stability in systems exhibiting vibrations. The method is applied to nonlinear feedback with VO fractional derivative. The results demonstrate the efficiency and high accuracy of the novel algorithm.
Filmästhetik als Potential medienkultureller Bildung
Authors: Lay Tristan
Published: March 2018

Der systematischen Implementierung filmspezifischer Arbeit im Fremdsprachenunterricht kommt in der Unterrichtsrealität immer noch eine marginale Rolle zu. Auch wenn seit etwa zehn Jahren ein Anstieg der Forschungsarbeiten zu diesem Themenbereich in den Disziplinen, die sich mit dem Lehren und Lernen fremder Sprachen auseinandersetzen, zu konstatieren ist, besteht indes in Fachveröffentlichungen der letzten Jahre Konsens darüber, dass der gezielte Filmeinsatz im landeskundlichen Sprachunterricht eher sporadisch ausfällt. Vor dem Hintergrund einer sich bereits vollzogenen visuellen Zeitenwende, die auch und insbesondere die Lebenswelt und Perzeptionsgewohnheiten unserer Lerner tiefgreifend verändert hat, ist die marginale Bedeutung und der aktuelle Stellenwert des Mediums Film in institutionalisierten Bildungskontexten kritisch zu hinterfragen. Eine stärkere Auseinandersetzung mit fremdsprachigen Filmen in der Sprach- und Kulturvermittlung kann beispielsweise durch die Erarbeitung und Bereitstellung von leicht adaptierbaren und modifizierbaren Didaktisierungsvorgaben gefördert werden. Dieser Beitrag möchte anhand des SpielfilmsLoreMöglichkeiten der Filmästhetik zur sprachlich-kulturellen Bildung von Deutschlernern aufzeigen, indem auf die Arbeit mit filmischen Gestaltungsmitteln für den Unterricht eingegangen wird, deren ästhetische Einbindung Voraussetzung einer erfolgreichen Kommunikation zwischen Film und Rezipient darstellt.
Filmwissenschaft als „Kulturwissenschaft aus der Ferne“
Authors: Viering Julia
Published: March 2018

Die Darstellung ausgewählter Ergebnisse einer Analyse öffentlich zugänglicher, vermeintlich wertungsfreier Informationsmaterialien soll veranschaulichen, wie die Auswahl spezifischer Darstellungsformen dazu beitragen kann, gesellschaftliche Ungleichheit zu reproduzieren. Angelehnt an die Diskursanalyse nach Viehöver, der Diskurse als Narrationen fasst, plädiert dieser Beitrag dafür, die Analyse filmischen Erzählens als Gegenstand empirischer Studien im DaF/DaZ-Kontext zu etablieren und forschungsmethod(olog)isch reflektiert einzusetzen. Ausgangspunkt war die Hypothese, dass innerhalb der einzelnen Berufsinformationsfilme nicht nur die berufliche, sondern auch die soziale/gesellschaftliche Integration junger Erwachsener narrativisiert wird und somit gesellschaftliche Integrationserwartungen sichtbar werden.
Informationswissenschaft in der Urbanistik
Authors: Stock Wolfgang G. , Barth Julia , Fietkiewicz Kaja J. , Gremm Julia , Hartmann Sarah , Henkel Maria , Ilhan Aylin , Mainka Agnes , Meschede Christine , Peters Isabella
Published: March 2018

Zeitgenössische und zukünftige Städte der Wissensgesellschaft werden oft als „smarte Städte“, „digitale Städte“ oder „ubiquitäre Städte“, „Wissensstädte“ und „kreative Städte“ bezeichnet. Die informationelle Urbanistik umfasst alle Aspekte von Information und (implizitem wie explizitem) Wissen in Hinblick auf städtische Regionen. „Informationelle Stadt“ (oder „smarte Stadt“ im weiteren Sinne) ist ein Sammelbegriff, der die unterschiedlichen Trends der informationsbezogenen Stadtforschung vereint. Die informationelle Stadtforschung ist ein interdisziplinäres Unternehmen, das einerseits Informatik und Informationswissenschaft sowie andererseits Stadtforschung, Stadtplanung, Architektur, Stadtökonomie und Stadtsoziologie vereint. In diesem Artikel präsentieren wir Ergebnisse unserer empirischen Studien über solche Städte auf der ganzen Welt. Der fundierende theoretische Rahmen besteht aus sieben Bausteinen, nämlich Informations- und Wissensinfrastrukturen, Wirtschaft, Politik (E-Governance) und Verwaltung (E-Government), Räume (Raum der Ströme und Raum der Orte), Standortfaktoren, das Informationsverhalten der Menschen und die Problembereiche.
Thermoluminescence properties of undoped diamond films deposited using HF CVD technique
Authors: Paprocki K. , Winiecki J. , Kabacińska R. , Przegietka K. , Szybowicz M. , Fabisiak K.
Published: March 2018

Natural diamond has been considered as a perspective material for clinical radiation dosimetry due to its tissuebiocompatibility and chemical inertness. However, the use of natural diamond in radiation dosimetry has been halted by the high market price. The recent progress in the development of CVD techniques for diamond synthesis, offering the capability of growing high quality diamond layers, has renewed the interest in using this material in radiation dosimeters having small geometricalsizes. Polycrystalline CVD diamond films have been proposed as detectors and dosimeters of β and α radiation with prospective applications in high-energy photon dosimetry. In this work, we present a study on the TL properties of undoped diamond film samples grown by the hot filament CVD (HF CVD) method and exposed to β and α radiation. The glow curves for both types of radiation show similar character and can be decomposed into three components. The dominant TL peaks are centered at around 610 K and exhibit activation energy of the order of 0.90 eV.
Crystal structure of 7-(4-methylphenyl)imidazo[1,2-a][1,3,5]triazin-4-amine, C12H11N5
Authors: Lim Felicia Phei Lin , Dolzhenko Anton V. , Halcovitch Nathan R. , Tiekink Edward R.T.
Published: March 2018

C12H11N5, monoclinic, P21/n (no. 14), a = 7.3455(1) Å, b = 12.2470(1) Å, c = 12.1689(1) Å, β = 103.505(1)°, V = 1064.45(2) Å3, Z = 4, R
gt(F) = 0.0365, wR
ref(F
2) = 0.0987, T = 100 K.
Success Criteria for Different Forms of Dialogue
Authors: Hösle Vittorio
Published: March 2018

The article proposes a typology of the forms of dialogue, which is influenced by Schleiermacher's triadic subdivision and distinguishes dialogues oriented toward agreement of wills, dialogues experienced as ends in themselves, and dialogues oriented toward agreement on truth. Each of these three types has different success criteria; particularly I show why Grice's maxims of conversation are not valid for all dialogues: In conversations, for example, irony is legitimate and enriching. The general reflections are then applied to the specific case of the intercultural dialogue.
“With God all things are possible” – Luther and Kierkegaard on the relation between immutability, necessity and possibility
Authors: Alfsvåg Knut
Published: March 2018

If God is eternal, he is immutable and his relationship with the world is without change. Luther and Kierkegaard agree that this is the case, but disagree whether the idea of necessity adequately captures God’s relationship with the world. Luther inherits the idea of necessity from the Scholastics, but rejects their distinction between absolute and conditional necessity. We can only trust God’s promises if there from God’s point of view are no contingencies. For Kierkegaard, the idea of necessity is determined by Kant’s understanding of reality as experience limited by what is possible according to the criteria of rationality. Kierkegaard finds this understanding insufficient, as it excludes the possibility of the infinite. In spite of differences of terminology caused by the differing contexts they had to address, there is thus a significant parallel between Luther and Kierkegaard in that they both criticize their contemporaries for having a deficient understanding of divine difference.
Apophatic Panentheism: Catherine Keller’s Constructive Theology
Authors: Benjamins Rick
Published: March 2018

Catherine Keller’s constructive theology includes an original and very interesting combination of process theology, feminist theology and negative theology. This combination culminates in the articulation of an “apophatic panentheism” that is urgent for its accentuation of connectivity and interdependency in our global world. In this article, Keller’s apophatic panentheism is clarified on the basis of her major works on the relational self, creation, apocalyptic patterns of thought, and negative theology.
‘Figures in 3D’: Digital Perspectives on Cretan Bronze Age Figurines
Authors: Morris Christine , Peatfield Alan , O’Neill Brendan
Published: March 2018

The largest corpus of clay figurines from the Cretan Bronze Age comes from ritual mountain sites known as peak sanctuaries. In this paper, we explore how the ‛Figures in 3D’ project contributes to our understanding of these figurines, aiding in the study of the technologies of figurine construction and the typological analysis of distinctive styles. We discuss how the project has, more unexpectedly, begun to create new dialogues and opportunities for moving between the material and the digital by taking a multifaceted approach that combines the data from 3D models and 3D prints with experimental work in clay.
A concise treatment of pterins: some recent synthetic and methodology aspects and their applications in molecular sensors
Authors: Goswami Shyamaprosad , Das Manas Kumar , Sain Dibyendu , Goswami Bhaswati
Published: March 2018

A concise account of pterins in chemistry and biology and their applications in molecular sensors including their optical spectroscopic properties are described. Different natural, synthetic, biological and photophysical aspects are also discussed. Synthetic access to direct functionalised pterins and a recently reported new thiophene annulation technique are described for the synthesis of Form B of molybdenum cofactor. The receptor properties of fluorescent pterin molecules including selenopyrimidines which are rarely reported for their binding of anions and neutral molecules are also of major importance in this review. For such an old and still so young, unexplored pterin system on its power to be sensitive for physical studies especially the interaction with cations, anions and neutral molecules are fascinating and research in this area is relatively new and expected to increase fast. Pterin based receptors are for the first time put into a useful review for the advantage of those who want to explore pterin and modified pterin as chromogenic and fluorogenic sensors.
Serum concentrations of TFF3, S100-A11 and AIF-1 in association with systemic inflammatory response, disease stage and nodal involvement in endometrial cancer
Authors: Pilka Radovan , Neubert David , Stejskal David , Krejčí Gabriela , Švesták Marek , Marek Radim , Adam Tomáš , Sobkova Katerina , Ondrová Dana , Hambálek Jozef , Maděrka Martin , Solichová Dagmar , Kujovská Krčmová Lenka , Javorska Lenka , Melichar Bohuslav
Published: March 2018

To compare preoperative intestinal trefoil factor 3 (TFF3), allograft inflammatory factor-1 (AIF-1) and calgizzarin (S100-A11) serum levels in patients with endometrial cancer, endometrial hyperplasia and in healthy female controls. Serum levels of TFF3, S100- A11 and AIP-1 were analyzed in 98 consecutive patients with histologically verified endometrial cancer, in 43 patients with endometrial hyperplasia diagnosed during hysteroscopy and 24 controls with benign disease. Results were correlated with urinary neopterin/creatinine ratio, serum kynurenine, tryptophan, retinol, alpha-tocopherol, vitamin D, citrulline, C-reactive protein, interleukin-6 and clinical characteristics. S100-A11, and AIF-1 levels were higher in endometrial hyperplasia patients than in controls, and also significantly higher in endometrial cancer than in patients with endometrial hyperplasia. Serum concentrations of TFF3 and S100-A11 were associated with tumor stage and lymph node status. TFF3 exhibited positive correlation with age, IL-6, vitamin D, kynurenine, urinary neopterin/creatinine ratio and kynurenine/tryptophan ratio. S100-A11, as well as AIF-1 correlated positively with Il-6 and TFF3. TFF3, S100-A11 and AIF-1 represent potential biomarkers in patients with endometrial cancer. TFF3 and S100-A11 increase with tumor stage and lymph node involvement, reflecting higher tumor mass that is also associated with increased concentration of biomarkers of immune dysfunction.
Upper limb therapy in children with cerebral palsy (CP) – The Pirate Group
Authors: Pawlak Marta , Wnuk Beata , Kowalicka Daniela , Rosłoniec Aleksandra
Published: March 2018

Introduction: Children with cerebral palsy (CP) in the form of spastic hemiplegia experience numerous difficulties concerning an affected upper limb such as reaching for objects, gripping or manipulating them. These limitations affect their everyday activity. Conducting an effective and simultaneously an interesting therapy aimed at meeting the child’s individual needs and improving upper limb function is a challenge for a physiotherapist. The aim of the study was to assess the effectiveness of upper limb therapy carried out within the project titled “The Pirate Group” based on Constraint-Induced Movement Therapy (CIMT) and Bimanual Training (BIT) conducted in a specially arranged environment. Material and methods: The research included 16 children with CP in the form of spastic hemiplegia. Mean age of the study participants was 4.23 years. The children underwent a two-week Constraint-Induced Movement Therapy (CIMT) combined with Bimanual Training (BIT). In order to evaluate the effects of the therapy, each child underwent the Assisting Hand Assessment (AHA) prior to the therapy and after its completion. Results: Statistical analysis revealed a significant difference (p<0.05) between the results of AHA prior to and after the therapy (t(14)=9.12, p<0.0001). An improvement in the affected upper limb function was noted in all the children participating in the research. Conclusions: The project titled “The Pirate Group”, based on CIMT and BIT is an effective therapeutic intervention which improves spontaneous activity of the affected upper limb in children with hemiplegia.
Erweiterte Abschreckung in Asien: aktuelle Lehren für Europa
Authors: Rühle Michael
Published: March 2018

Die US-amerikanische Politik der erweiterten Abschreckung für ihre Verbündeten in Ostasien ist durch die nuklearen Ambitionen Nordkoreas sowie die zunehmend militärisch unterfütterte Außenpolitik Chinas erneut ins Zentrum der Betrachtung gerückt. Die aktuelle Diskussion in Asien zeigt – nach einer Phase des Herunterspielens der nuklearen Dimension in der Sicherheits- und Bündnispolitik – erneut die bedeutende Rolle der erweiterten Abschreckung als Instrument zur Rückversicherung für die Verbündeten und damit zugleich zur Verhinderung der Weiterverbreitung von Nuklearwaffen. Für Europa, dessen nukleare Kooperation mit den USA im Rahmen der NATO institutionalisiert ist, bietet diese Debatte zahlreiche Lehren.
Protective effect of dexpanthenol (vitamin B5) in a rat model of LPS-induced endotoxic shock
Authors: Demirci Buket , Yilmaz Mustafa , Bektas Uysal Hilal
Published: March 2018

Objectives

This study investigated the protective effect of dexpanthenol (DEX) in the septic shock model of rats with biochemical parameters.

Methods

12–15 weeks old male 32 Wistar rats has been used for this study. Sepsis was induced by a single intraperitoneal injection of lipopolysaccharide (LPS) (5 mg/kg) and treatment groups received single intraperitoneal injection of DEX (500 mg/kg) just 30-min before. The blood and tissue samples were obtained 16 h later of LPS intervention under the ketamine and xylasine (50 and 5 mg/kg, respectively) anesthesia.

Results

Giving alone DEX did not alter any physiologic levels of biochemical markers. Induction of sepsis resulted in a marked increase in ALT, AST, urea, creatinine, lactate, procalcitonin, TNF-α, IL-1β levels to show the tissue damage. In all serum parameters, liver’s GSH, CAT levels and kidney’s CAT, GSH, MDA and NO levels have ameliorated by DEX treatment in sepsis group.

Conclusion

Along with the standard therapy of sepsis, DEX can be used as a safe way of restoring (anti)oxidant status of kidney and liver tissues. It can be effective to control cytokine pathway, to decrease procalcitonin and regulate the metabolic process of sepsis, such as lactate.
Efficient pseudo five-component synthesis of 4,4′-(arylmethylene)-bis(3-methyl-1-phenyl-1H-pyrazol-5-ol) derivatives promoted by a novel ionic liquid catalyst
Authors: Abshirini Zahra , Zare Abdolkarim
Published: March 2018

In this research, initial production and characterization of a novel Brønsted-acidic ionic liquid, namely, N,N,N′,N′-tetramethylethylenediaminium-N,N′-disulfonic acid hydrogen sulfate ([TMEDSA][HSO4]2), has been described (characterization was achieved using Fourier-transform infrared spectroscopy, 1H nuclear magnetic resonance (NMR), 13C NMR, and mass and thermal gravimetric spectra). Thereafter, utilization of [TMEDSA][HSO4]2 as a highly effectual catalyst for the synthesis of 4,4′-(arylmethylene)-bis(3-methyl-1-phenyl-1H-pyrazol-5-ol) derivatives through the one-pot pseudo five-component reaction of phenylhydrazine (2 eq.) with ethyl acetoacetate (2 eq.) and arylaldehydes (1 eq.) in relatively mild conditions, has been reported.
2-Naphthol-pyrazole conjugates as substrates in the Mannich reaction
Authors: Roman Gheorghe
Published: March 2018

Several novel 2-naphthol-pyrazole conjugates have been synthesized through the O-alkylation of 1-[(3,5-dimethyl-1H-pyrazol-1-yl)methyl]naphthalen-2-ol with methyl iodide, benzyl chloride, methyl bromoacetate and N-benzyl-2-bromoacetamide. The aminomethylation of these 2-naphthol-pyrazole conjugates has been examined employing the classical conditions for the Mannich reaction, and also by using N,N-dimethylmethyleneiminium chloride as preformed aminomethylating reagent. In both situations, aminomethylation of these substrates occurred at C-4 of the pyrazole ring. The bifunctional substrate 1-[(3,5-dimethyl-1H-pyrazol-1-yl)methyl]naphthalen-2-ol has been chemoselectively aminomethylated in the pyrazole ring using the same preformed aminomethylating reagent.
Una lauda e uno scongiuro da un registro dell’Archivio di Stato di Udine
Authors: Zanello Gabriele
Published: March 2018

Giovanni Antonio Battaglia was a notary and a secular priest of the diocese of Aquileia. He was active between the late fifteenth and the first four decades of the sixteenth century in Gemona, his place of birth, in the castle of Porcia and the city of Udine. A register he compiled (Udine, Archivio notarile antico, n. 2247), contains two documents which are worthy of attention. The first one is a funeral lauda in Italian vernacular which completes the rather short list of the religious laude repertoire of the Friulian region between the fifteenth and sixteenth centuries. The second document is the text Dolce Regina, dona la tua pace. This work can be placed within the framework of the brotherhoods of the Battuti, which Battaglia served as a priest and as a teacher. A rather composite Latin text also appears on the same page of the notarial register. It includes an invocation to the Magi, a quote from the Scriptures and an adapted liturgical oration. The presence of this exorcism, unusual if compared to the local context of traditional beliefs and therapeutic practices, requires wide-ranging comparisons. The figure of Battaglia himself also deserves further analysis especially in order to understand his cultural background as well as clarifying his relationship with the humanists whom he was corresponding with.
Les soviétismes en roumain et dans les langues romanes
Authors: Costăchescu Adriana
Published: March 2018

The article focusses on the fate of Sovietisms in modern Romanian, i.e. the situation of words or phrases borrowed from Russian in the period of Soviet control over Eastern Europe (1945–1989). The borrowings reflect relevant concepts of Soviet-Communist economics, culture, politics and propaganda. Romanian received the largest number of Sovietisms of all Romance languages, mainly because of its close political relationship with the URSS. The use of terms which implicated a critical attitude towards the Soviet-Communist dictatorship (samizdat ‘samizdat’, aparatcic ‘apparatchik’, gulag ‘goulag’, etc.) was forbidden both in the URSS and in socialist Romania, but they passed into Russian and Romanian through western radio broadcasts, mainly Radio Free Europe/Radio Liberty. Today, most of those Sovietisms are no longer in use in Romanian.
Synthesis and Performance Evaluation of Epoxy Resin–Modified Shape Memory Polyurethane Sealant
Authors: Shen Dongya , Shi Shuang , Xu Tao
Published: March 2018

To evaluate the effects of epoxy resin (EP) on different properties of shape memory polyurethane (SMPU) when used as a sealant with a tailored thermal transition temperature (Tt) for concrete pavement joints, the thermal and dynamic mechanical performances were discussed to determine the shape memory switching temperature of EP-modified SMPU, and then the compatibility between EP and SMPU, microscopic morphology, shape memory effect, and tensile property were also characterized. The results indicate that the tailored Tt of EP-modified SMPU can be used as the shape memory switching temperature to match its working temperature. EP and SMPU show considerable compatibility. EP inhibits the crystallization of soft phase content and increases the hard phase content. Both hydroxyl and epoxy groups participate in chemical reactions. The ring-opening reactions occur between fractional benzenes and SMPU. EP was successfully grafted onto the main chains of SMPU. Additionally, the peak load, tensile strength, and elongation at break of SMPU are first increased and then decreased when the EP content increase. An EP content of 10 % improves the tensile properties of SMPU, but excessive EP content leads to a decrease in the tensile strength and elongation at break. Finally, it is found that a small amount of EP has little influence on the shape memory properties of SMPU, but EP can improve the tensile properties of SMPU. EP-modified SMPU shows excellent shape memory effects. The prepared EP-modified SMPU with the specially tailored Tt can meet the requirements of practical engineering when used as a sealant for concrete pavement joints.