bluuebunny/crossref_metadata_2025 huggingface dataset:
Tau-PET and in vivo Braak-staging as prognostic markers of future cognitive decline in cognitively normal to demented individuals
Authors: Biel Davina , Brendel Matthias , Rubinski Anna , Buerger Katharina , Janowitz Daniel , Dichgans Martin , Franzmeier Nicolai ,   for the Alzheimer’s Disease Neuroimaging Initiative (ADNI)
Published: August 2021

Background

To systematically examine the clinical utility of tau-PET and Braak-staging as prognostic markers of future cognitive decline in older adults with and without cognitive impairment.

Methods

In this longitudinal study, we included 396 cognitively normal to dementia subjects with 18F-Florbetapir/18F-Florbetaben-amyloid-PET, 18F-Flortaucipir-tau-PET and ~ 2-year cognitive follow-up. Annual change rates in global cognition (i.e., MMSE, ADAS13) and episodic memory were calculated via linear-mixed models. We determined global amyloid-PET (Centiloid) plus global and Braak-stage-specific tau-PET SUVRs, which were stratified as positive(+)/negative(−) at pre-established cut-offs, classifying subjects as Braak0/BraakI+/BraakI–IV+/BraakI–VI+/Braakatypical+. In bootstrapped linear regression, we assessed the predictive accuracy of global tau-PET SUVRs vs. Centiloid on subsequent cognitive decline. To test for independent tau vs. amyloid effects, analyses were further controlled for the contrary PET-tracer. Using ANCOVAs, we tested whether more advanced Braak-stage predicted accelerated future cognitive decline. All models were controlled for age, sex, education, diagnosis, and baseline cognition. Lastly, we determined Braak-stage-specific conversion risk to mild cognitive impairment (MCI) or dementia.

Results

Baseline global tau-PET SUVRs explained more variance (partial R2) in future cognitive decline than Centiloid across all cognitive tests (Cohen’s d ~ 2, all tests p < 0.001) and diagnostic groups. Associations between tau-PET and cognitive decline remained consistent when controlling for Centiloid, while associations between amyloid-PET and cognitive decline were non-significant when controlling for tau-PET. More advanced Braak-stage was associated with gradually worsening future cognitive decline, independent of Centiloid or diagnostic group (p < 0.001), and elevated conversion risk to MCI/dementia.

Conclusion

Tau-PET and Braak-staging are highly predictive markers of future cognitive decline and may be promising single-modality estimates for prognostication of patient-specific progression risk in clinical settings.
A primer on deep learning and convolutional neural networks for clinicians
Authors: Iglesias Lara Lloret , Bellón Pablo Sanz , del Barrio Amaia Pérez , Fernández-Miranda Pablo Menéndez , González David Rodríguez , Vega José A. , Mandly Andrés A. González , Blanco José A. Parra
Published: August 2021

Deep learning is nowadays at the forefront of artificial intelligence. More precisely, the use of convolutional neural networks has drastically improved the learning capabilities of computer vision applications, being able to directly consider raw data without any prior feature extraction. Advanced methods in the machine learning field, such as adaptive momentum algorithms or dropout regularization, have dramatically improved the convolutional neural networks predicting ability, outperforming that of conventional fully connected neural networks. This work summarizes, in an intended didactic way, the main aspects of these cutting-edge techniques from a medical imaging perspective.
RETRACTED ARTICLE: GDF11 enhances therapeutic functions of mesenchymal stem cells for angiogenesis
Authors: Zhang Chi , Lin Yinuo , Zhang Ke , Meng Luyang , Hu Xinyang , Chen Jinghai , Zhu Wei , Yu Hong
Published: August 2021

Background

The efficacy of stem cell therapy for ischemia repair has been limited by low cell retention rate. Growth differentiation factor 11 (GDF11) is a member of the transforming growth factor-β super family, which has multiple effects on development, physiology and diseases. The objective of the study is to investigate whether GDF11 could affect the efficacy of stem cell transplantation.

Methods

We explored the effects of GDF11 on proangiogenic activities of mesenchymal stem cells (MSCs) for angiogenic therapy in vitro and in vivo.

Results

Mouse bone marrow-derived MSCs were transduced with lentiviral vector to overexpress GDF11 (MSCGDF11). After exposed to hypoxia and serum deprivation for 48 h, MSCGDF11 were significantly better in viability than control MSCs (MSCvector). MSCGDF11 also had higher mobility and better angiogenic paracrine effects. The cytokine antibody array showed more angiogenic cytokines in the conditioned medium of MSCGDF11 than that of MSCvector, such as epidermal growth factor, platelet-derived growth factor-BB, placenta growth factor. When MSCs (1 × 106 cells in 50 μl) were injected into ischemic hindlimb of mice after femoral artery ligation, MSCGDF11 had higher retention rate in the muscle than control MSCs. Injection of MSCGDF11 resulted in better blood reperfusion and limb salvage than that of control MSCs after 14 days. Significantly more CD31+ endothelial cells and α-SMA + smooth muscle cells were detected in the ischemic muscles that received MSCGDF11. The effects of GDF11 were through activating TGF-β receptor and PI3K/Akt signaling pathway.

Conclusion

Our study demonstrated an essential role of GDF11 in promoting therapeutic functions of MSCs for ischemic diseases by enhancing MSC viability, mobility, and angiogenic paracrine functions.
Rendering neuronal state equations compatible with the principle of stationary action
Authors: Fagerholm Erik D. , Foulkes W. M. C. , Friston Karl J. , Moran Rosalyn J. , Leech Robert
Published: August 2021

The principle of stationary action is a cornerstone of modern physics, providing a powerful framework for investigating dynamical systems found in classical mechanics through to quantum field theory. However, computational neuroscience, despite its heavy reliance on concepts in physics, is anomalous in this regard as its main equations of motion are not compatible with a Lagrangian formulation and hence with the principle of stationary action. Taking the Dynamic Causal Modelling (DCM) neuronal state equation as an instructive archetype of the first-order linear differential equations commonly found in computational neuroscience, we show that it is possible to make certain modifications to this equation to render it compatible with the principle of stationary action. Specifically, we show that a Lagrangian formulation of the DCM neuronal state equation is facilitated using a complex dependent variable, an oscillatory solution, and a Hermitian intrinsic connectivity matrix. We first demonstrate proof of principle by using Bayesian model inversion to show that both the original and modified models can be correctly identified viain silicodata generated directly from their respective equations of motion. We then provide motivation for adopting the modified models in neuroscience by using three different types of publicly availablein vivoneuroimaging datasets, together with open source MATLAB code, to show that the modified (oscillatory) model provides a more parsimonious explanation for some of these empirical timeseries. It is our hope that this work will, in combination with existing techniques, allow people to explore the symmetries and associated conservation laws within neural systems – and to exploit the computational expediency facilitated by direct variational techniques.
Substances use between early and later stages of the COVID-19 pandemic in Israel
Authors: Bonny-Noach Hagit , Cohen-Louck Keren , Levy Inna
Published: August 2021

Aims

Only several empirical studies have examined substance use during the COVID-19 pandemic in general populations. Most of these studies compared self-reported substances use before the pandemic and during the pandemic's early stages. This study aims to identify the changes in substance use between the early and later waves of the COVID-19 pandemic in Israel.

Methods

A cross-sectional online survey recruited 750 participants (ages 18–65) in two waves: (1) 427 during and following the first lockdown (April-mid-May, 2020); and (2) 323 following the second lockdown (from October to mid-November, 2020).

Results

Participants who experienced two lockdowns reported more frequent consumption of all alcoholic beverages and cannabis in the last 30 days than those who experienced one lockdown. After controlling for demographic variables, significant differences were found between participants who experienced one lockdown and those who experienced two lockdowns in the consumption of alcoholic beverages (F(1, 742) = 6.90, p = .01, η2 = .01). However, there was no significant association between pandemic duration and other illegal drug consumption.

Conclusions

There is a significant association between pandemic duration and alcohol consumption. Policymakers and practitioners should develop national alcohol and cannabis use prevention and harm reduction interventions during pandemics with a focus on men, singles and youth.
The assessment of general movements in term and late-preterm infants diagnosed with neonatal encephalopathy, as a predictive tool of cerebral palsy by 2 years of age—a scoping review
Authors: Seesahai Judy , Luther Maureen , Church Paige Terrien , Maddalena Patricia , Asztalos Elizabeth , Rotter Thomas , Banihani Rudaina
Published: August 2021

Background

The General Movements Assessment is a non-invasive and cost-effective tool with demonstrated reliability for identifying infants at risk for cerebral palsy. Early detection of cerebral palsy allows for the implementation of early intervention and is associated with better functional outcomes. No review to date has summarized the utility of the General Movements Assessment to predict cerebral palsy in term and late-preterm infants diagnosed with neonatal encephalopathy.

Methods

We conducted a scoping review involving infants born greater than or equal to 34 weeks gestational age to identify all available evidence and delineate research gaps. We extracted data on sensitivity, specificity, and positive and negative predictive values and described the strengths and limitations of the results. We searched five databases (MEDLINE, Embase, PsychINFO, Scopus, and CINAHL) and the General Movements Trust website. Two reviewers conducted all screening and data extraction independently. The articles were categorized according to key findings, and a critical appraisal was performed.

Results

Only three studies, a cohort and two case series, met all of the inclusion criteria. The total number of participants was 118. None of the final eligible studies included late-preterm neonates. All three studies reported on sensitivity, specificity, and positive predictive and negative predictive values. An abnormal General Movement Assessment at 3–5 months has a high specificity (84.6–98%) for cerebral palsy with a similarly high negative predictive value (84.6–98%) when it was normal. Absent fidgety movements, in particular, are highly specific (96%) for moderate to severe cerebral palsy and carry a high negative predictive value (98%) when normal. In the time period between term and 4–5 months post-term, any cramped synchronized movements had results of 100% sensitivity and variable results for specificity, positive predictive value, and negative predictive value.

Conclusions

A normal General Movements Assessment at 3 months in a term high-risk infant is likely associated with a low risk for moderate/severe cerebral palsy. The finding of cramped synchronized General Movements is a strong predictor for the diagnosis of cerebral palsy by 2 years of age in the term population with neonatal encephalopathy. The deficit of high-quality research limits the applicability, and so the General Movements Assessment should not be used in isolation when assessing this population.

Systematic review registration

Title registration with Joanna Briggs Institute. URL:http://joannabriggswebdev.org/research/registered_titles.aspx.
Nosocomial infections among COVID-19 patients: an analysis of intensive care unit surveillance data
Authors: Ong Clara Chong Hui , Farhanah Sharifah , Linn Kyaw Zaw , Tang Ying Wei , Poon Chu Ying , Lim Allie Yin , Tan Hui Ru , Binte Hamed Nur Hafizah , Huan Xiaowei , Puah Ser Hon , Ho Benjamin C. H. , Soon Margaret M. L. , Ang Brenda S. P. , Vasoo Shawn , Chan Monica , Leo Yee Sin , Ng Oon Tek , Marimuthu Kalisvar
Published: August 2021

Surveillance of nosocomial infections, like catheter-associated urinary tract infection (CAUTI), central line-associated bloodstream infection, possible ventilator-associated pneumonia and secondary bloodstream infections were observed to study the impact of COVID-19 outbreak in ICUs from Tan Tock Seng Hospital and National Centre for Infectious Diseases, Singapore between February and June 2020. Higher nosocomial infection rates were observed in COVID-19 patients, although it was not statistically significant. Moreover, COVID-19 patients seem to be more predisposed to CAUTI despite a higher proportion of non-COVID-19 patients having urinary catheters. Thus, continued vigilance to ensure adherence to IPC measures is needed.
Regulation of bone phosphorus retention and bone development possibly by related hormones and local bone-derived regulators in broiler chicks
Authors: Cao Sumei , Li Tingting , Shao Yuxin , Zhang Liyang , Lu Lin , Zhang Rijun , Hou Shuisheng , Luo Xugang , Liao Xiudong
Published: August 2021

Background

Phosphorus is essential for bone mineralization in broilers, however, the underlying mechanisms remain unclear. We aimed to investigate whether bone phosphorus retention and bone development might be regulated by related hormones and local bone-derived regulators in broilers.

Methods

Broilers were fed diets containing different levels of non-phytate phosphorus (NPP) 0.15%, 0.25%, 0.35%, 0.45% and 0.55% or 0.15%, 0.22%, 0.29%, 0.36% and 0.43% from 1 to 21 or 22 to 42 days of age. Serum and tibia samples were collected for determinations of bone phosphorus retention and bone development parameters, related hormones and local bone-derived regulators of broiler chickens on d 14, 28 and 42, respectively.

Results

Tibia ash phosphorus, total phosphorus accumulation in tibia ash (TPTA), bone mineral concentration (BMC), bone mineral density (BMD), bone breaking strength (BBS), and ash on d 14, 28 or 42, serum 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) on d 28 and 42, mRNA expressions of tibia fibroblast growth factor 23 (FGF23) and dentin matrix protein 1 (DMP1) on d 14 and 28 increased linearly or quadratically (P < 0.05), while serum parathyroid hormone (PTH) on d 28, tibia alkaline phosphatase (ALP) on d 14, 28 and 42, bone gal protein (BGP) on d 14, and mRNA expression of tibia phosphate-regulating gene with homologies to endopeptidases on the X chromosome (PHEX) on d 14 and 28 decreased linearly or quadratically (P < 0.04) as dietary NPP level increased. TPTA, BMC, BMD, and ash on d 28 and 42, BBS on d 28, and ash phosphorus on d 42 were positively correlated (r = 0.389 to 0.486, P < 0.03) with serum 1,25(OH)2D3. All of the above parameters were positively correlated (r = 0.380 to 0.689, P < 0.05) with tibia DMP1 mRNA expression on d 14, 28 and 42, but negatively correlated (r = − 0.609 to − 0.538, P < 0.02) with serum PTH on d 28, tibia ALP on d 14, 28 and 42, and BGP on d 14. TPTA, BMC and ash on d 14 and BMD on d 28 were negatively correlated (r = − 0.397 to − 0.362, P < 0.03) with tibia PHEX mRNA expression, and BMD on d 28 was positively correlated (r = 0.384, P = 0.04) with tibia FGF23 mRNA expression.

Conclusions

These results suggested that bone phosphorus retention and bone development parameters had moderate to strong correlations with serum PTH and 1,25(OH)2D3 and tibia DMP1, PHEX, FGF23, ALP and BGP in broilers during the whole growth period, and thus they might be partly regulated by these related hormones and local bone-derived regulators.
Identification and attribute analysis of key stakeholders who influence multidrug-resistant tuberculosis prevention and control in China
Authors: Chen Bin , Bao Hongdan , Chen Xinyi , Liu Kui , Peng Ying , Wang Wei , Wang Fei , Jiang Jianmin , Xu Biao
Published: August 2021

Background

There could be various stakeholders who influencing multidrug-resistant tuberculosis (MDR-TB) policy development and implementation, yet their attributes and roles remain unclear in practice. This study aimed to identify key stakeholders in the process of policy-making for MDR-TB control and prevention and to analyse the attributes and relationships of the stakeholders, providing evidence for further policy research on MDR-TB control.

Methods

This study was conducted from October 2018 to March 2019 and applied the stakeholder analysis guidelines and domestic stakeholder analysis. An initial candidate stakeholder list was developed by policy scanning. Ten experts were invited to identify these candidate stakeholders. The major attribute of these stakeholders were analysed using the Michell scoring method. Based on these results, the intertwined relationships among groups of stakeholders were analysed and mapped through a systematic scan of the policy and literature on MDR-TB control, as well as information obtained from the interviews.

Results

A list of 21 types of candidate stakeholders was developed after a literature review and policy scanning, of which 11 received 100% approval. After expert evaluation and identification (the total expert authority was 0.80), 19 categories of stakeholders were approved and included in the stakeholder analysis. We categorized all of the stakeholders into three groups: (i) definitive stakeholders who are mainly involved in administrative departments and the Provincial Center for Disease Control and Prevention (CDC); (ii) expectant stakeholders who are mainly involved with MDR-TB patients, clinical departments of TB hospitals at different levels, community health care facilities, prefectural CDC and charity organizations; and (iii) latent stakeholders who mainly involved family members and neighbours of MDR-TB patients and TB related products manufacturers. Government departments and higher-level CDCs have strong decision-making power in developing MDR-TB control policies whereas the recommendations from service providers and the concerns of patients should be considered.

Conclusions

The MDR-TB prevention system was a multistakeholder cooperation system that was mainly led by government stakeholders. Enhancing communications with front-line service providers and patients on their unmet needs and evidence-based suggestions would highly benefit policy-making of MDR-TB prevention and control.

Graphical abstract
Outcomes of endoscopic chemo- and laser-cauterizations and open fistulectomy for pyriform sinus fistula
Authors: Masuoka Hiroo , Miyauchi Akira , Sasaki Takahiro , Sano Tsutomu , Miya Akihiro
Published: August 2021

Background

Acute suppurative thyroiditis through the congenital pyriform sinus fistula (PSF) often recurs if the fistula is not resected. Although endoscopic chemo-cauterization (ECC) to obliterate the orifice of the fistula is less invasive than open fistulectomy, it may require repeated treatments. We recently adopted an endoscopic diode laser-cauterization (ELC) system with the intention of improving treatment outcomes in PSF. Here, we describe ELC and compare the outcomes of these three modalities.

Methods

We evaluated 83 patients with PSF who underwent treatment between 2007 and 2018 at Kuma Hospital, a tertiary thyroid treatment hospital. ECC and ELC were implemented in 2007 and 2015, respectively. Patients who were ineligible for the endoscopic procedures underwent open fistulectomy. Barium swallow studies and computed tomography scan under a trumpet maneuver were performed after treatment to evaluate obliteration or removal of the fistula.

Results

In total, 70 of the 81 (86%) patients who underwent barium swallow studies after the first treatment achieved obliteration or removal of the fistula. The success rates for open fistulectomy, ECC, and ELC were 100% (9/9), 83% (49/59), and 100% (13/13), respectively. ECC and ELC had significantly shorter operative times and lower blood loss than open fistulectomy. Insufficient opening of the mouth was the major reason for converting endoscopic procedures to open fistulectomy.

Conclusions

ELC may yield superior outcomes and is therefore the optimal treatment modality for PSF. However, it is still associated with certain limitations. Thus, treatment selection remains dependent on the shape and size of the PSF and the mouth opening of the individual patient.

Graphical Abstract
Study on effect of laboratory roller compaction on unconfined compressive strength of lime treated soils
Authors: Nagesh Sureka , Jagadeesh H. S. , Nithin K. S.
Published: August 2021

Expansive soils are problematic due to their swell—shrinkage behavior and low compressive strength. They are modified generally with additives such as lime, fly ash, and various other inorganic and organic materials. Chemical stabilization treatments can improve expansive soil properties for its reuse in geotechnical applications. The present study investigates the properties of two types of subgrade soil treated with Lime and compacted by three different methods in the laboratory. The study is mainly focused to bring out the effect of different methods of compaction on the unconfined compressive strength of Lime treated soils and untreated soils. Laboratory investigation included pH, Atterberg limits, cation exchange capacity (CEC), compaction, unconfined compression strength (UCS), California Bearing Ratio (CBR), Scanning Electron Micrographs (SEM) and EDAX before and after lime treatment. Tests were performed on lime treated soils (2, 4, 6 and 8% of lime). The soil samples for unconfined compressive strength test were prepared by static, dynamic and roller compaction methods in the laboratory. Roller compaction was performed using indigenously fabricated Roller compactor cum Rutting Analyzer (RCRA). The results indicate that dry unit weight and UCS of roller compacted lime treated soil is lower than that of dynamic compacted soil. However, dry unit weight and UCS of lime treated roller compacted soil are closer to that of statically compacted soil. Cation exchange capacity of both soils before and after treatment with lime were examined, CEC reduced with increase in lime content.
A new combination technique of the modified Robicsek wire fixation and plate fixation achieves effective repair of transverse sternal fracture: a report of two cases
Authors: Fuke Yoshifumi , Ushijima Tomoki , Matsuyama Sho , Kimura Satoshi , Sonoda Hiromichi , Osawa Sayaka , Maki Jun , Tokuda Kentaro , Momii Kenta , Shiose Akira
Published: August 2021

Background

To maximize the therapeutic effect for complicated sternal fracture, we should know advantages and disadvantages of each surgical repositioning technique, and the choice of an appropriate procedure is essential. We report two successful cases for which a combination of two existing techniques, modified Robicsek wire fixation and locked titanium plate fixation, was applied to transverse sternal fracture with flail chest.

Case presentation

One patient experienced a transverse sternal and rib fracture due to a traffic injury. Flail chest due to a highly displaced transverse sternal fracture made withdrawal of the ventilator impossible. Another patient, who developed fulminant myocarditis, experienced a transverse sternal fracture resulting from chest compression during cardiopulmonary resuscitation. Severe paradoxical respiratory movement was a limiting factor for cardiac and respiratory rehabilitation. In both cases, a transverse sternal fracture was difficult to correct non-invasively and indicated surgical repair. The surgical repositioning and fixation greatly contributed to the improvement of the respiratory movement, and the patients were successfully withdrawn ventilator support.

Conclusion

The combination of modified Robicsek wire fixation and locked titanium plate fixation for a complicated sternal fracture employs the complementary and comparative advantages of each procedure and effective fixation may be achieved.
Practical Aspects of Implementing and Applying Health Care Cloud Computing Services and Informatics to Cancer Clinical Trial Data
Authors: Ronquillo Jay G. , Lester William T.
Published: August 2021

PURPOSE

Cloud computing has led to dramatic growth in the volume, variety, and velocity of cancer data. However, cloud platforms and services present new challenges for cancer research, particularly in understanding the practical tradeoffs between cloud performance, cost, and complexity. The goal of this study was to describe the practical challenges when using a cloud-based service to improve the cancer clinical trial matching process.

METHODS

We collected information for all interventional cancer clinical trials from ClinicalTrials.gov and used the Google Cloud Healthcare Natural Language Application Programming Interface (API) to analyze clinical trial Title and Eligibility Criteria text. An informatics pipeline leveraging interoperability standards summarized the distribution of cancer clinical trials, genes, laboratory tests, and medications extracted from cloud-based entity analysis.

RESULTS

There were a total of 38,851 cancer-related clinical trials found in this study, with the distribution of cancer categories extracted from Title text significantly different than in ClinicalTrials.gov ( P < .001). Cloud-based entity analysis of clinical trial criteria identified a total of 949 genes, 1,782 laboratory tests, 2,086 medications, and 4,902 National Cancer Institute Thesaurus terms, with estimated detection accuracies ranging from 12.8% to 89.9%. A total of 77,702 API calls processed an estimated 167,179 text records, which took a total of 1,979 processing-minutes (33.0 processing-hours), or approximately 1.5 seconds per API call.

CONCLUSION

Current general-purpose cloud health care tools—like the Google service in this study—should not be used for automated clinical trial matching unless they can perform effective extraction and classification of the clinical, genetic, and medication concepts central to precision oncology research. A strong understanding of the practical aspects of cloud computing will help researchers effectively navigate the vast data ecosystems in cancer research.
Fluorouracil Bolus Use in Infusional Regimens Among Oncologists—A Survey by Brazilian Group of Gastrointestinal Tumors
Authors: Peixoto Renata D. , Coutinho Anelisa K. , Weschenfelder Rui Fernando , Prolla Gabriel , Rocha Duilio , Andrade Aline Chaves , Rego Juliana Florinda , Fernandes Gustavo dos Santos , Crosara Marcela , Hoff Paulo Marcelo , Dienstmann Rodrigo , Costa e Silva Matheus , Riechelmann Rachel P.
Published: August 2021

PURPOSE

The utility of administering fluorouracil (5-FU) in bolus in regimens of infusional 5-FU has been questioned. We aimed to quantify the use of 5-FU bolus in infusional regimens for gastrointestinal malignancies among Brazilian oncologists.

METHODS

This was a cross-sectional electronic survey composed of eight multiple-choice questions sent to Brazilian oncologists during 14 days in February 2021. The survey instrument collected demographic data of participants and assessed practices in terms of 5-FU bolus use. We evaluated the association of demographic variables and 5-FU prescribing patterns with Fisher’s exact test (odds ratio [OR]).

RESULTS

The survey was completed by 332 medical oncologists. Overall, 37% were experienced oncologists and 32% were gastrointestinal specialists. In the first-line metastatic and in the adjuvant settings, 40% and 67% of oncologists always prescribe 5-FU bolus in infusional regimens, respectively. Experienced oncologists more frequently omit 5-FU bolus when compared with early-career oncologists, both in the metastatic (41% v 26%; OR, 1.98; P = .005) and adjuvant settings (28% v 14%; OR, 2.32; P = .003). In addition, more GI specialists remove 5-FU bolus when compared with generalists, but only in the metastatic setting (44% v 25%; OR, 2.33; P = .001). GI specialists are more likely to consider that treatment efficacy is not affected by 5-FU bolus withdrawal than are generalists (89% v 75%; OR, 2.65; P = .003). Most respondents (67%) keep leucovorin at the same doses when omitting 5-FU bolus, and only 16% always recommend dihydropyrimidine dehydrogenase testing.

CONCLUSION

Our survey indicates that experience in oncology practice and percentage of time dedicated to treat GI cancers influence the prescription of 5-FU bolus in Brazil, with more frequent omission of it among experienced gastrointestinal specialists, particularly in the metastatic setting.
Hawai'i Is My Haven
Authors: Sharma Nitasha Tamar
Published: August 2021

Hawaiʻi Is My Haven maps the context and contours of Black life in the Hawaiian Islands. This ethnography emerges from a decade of fieldwork with both Hawaiʻi-raised Black locals and Black transplants who moved to the Islands from North America, Africa, and the Caribbean. Nitasha Tamar Sharma highlights the paradox of Hawaiʻi as a multiracial paradise and site of unacknowledged antiBlack racism. While Black culture is ubiquitous here, African-descended people seem invisible. In this formerly sovereign nation structured neither by the US Black/White binary nor the one-drop rule, nonWhite multiracials, including Black Hawaiians and Black Koreans, illustrate the coarticulation and limits of race and the native/settler divide. Despite erasure and racism, nonmilitary Black residents consider Hawaiʻi their haven, describing it as a place to “breathe” that offers the possibility of becoming local. Sharma's analysis of race, indigeneity, and Asian settler colonialism shifts North American debates in Black and Native studies to the Black Pacific. Hawaiʻi Is My Haven illustrates what the Pacific offers members of the African diaspora and how they in turn illuminate race and racism in “paradise.”
Visual acuity of budgerigars for moving targets
Authors: Chaib Sandra , Mussoi Juliane Gaviraghi , Lind Olle , Kelber Almut
Published: August 2021

For a bird, it is often vital to visually detect food items, predators, or individuals from the same flock, i.e. moving stimuli of various shapes. Yet, behavioural tests of visual spatial acuity traditionally use stationary gratings as stimuli. We have behaviourally tested the ability of budgerigars (Melopsittacus undulatus) to detect a black circular target, moving semi-randomly at 1.69 degrees s−1 against a brighter background. We found a detection threshold of 0.107±0.007 degrees of the visual field for a target size corresponding to a resolution of a grating with a spatial frequency of 4.68 cycles degree−1. This detection threshold is lower than the resolution limit for gratings but similar to the threshold for stationary single objects of the same shape. We conclude that the target acuity of budgerigars for moving single targets, just as for stationary single targets, is lower than their acuity for gratings.
Feasibility of arterial spin labeling in evaluating high- and low-flow peripheral vascular malformations: a case series
Authors: Ramachandran Sanjeev , Delf Jonathan , Kasap Christopher , Adair William , Rayt Harjeet , Bown Matthew , Kandiyil Neghal
Published: August 2021

We present a case series highlighting a novel use of arterial spin labeling (ASL), a MRI perfusion technique, to evaluate both high- and low-flow peripheral vascular malformations (PVMs) across a range of anatomical locations. While the role of ASL in assessing intracranial vascular malformations is more established, there is limited evidence for PVMs. Our results provide preliminary evidence for the feasibility of ASL in imaging PVMs and its potential ability to distinguish between high- and low-flow PVMs. In addition, we demonstrate its ability to identify focal high blood flow, which may indicate the nidus in arteriovenous malformations. Together, these findings have important implications for patient management. We also outline the potential benefits and limitations of ASL in the imaging of PVMs, and provide justification for further validation of its diagnostic performance.
Future land use change simulations for the Lepelle River Basin using Cellular Automata Markov model with Land Change Modeller-generated transition areas
Authors: Ikegwuoha Darlington Chineye , Weepener Harold Louw , Dinka Megersa Olumana
Published: August 2021

Background: Land cover/land cover (LULC) change is one of the major contributors to global environmental and climate variations. The ability to predict future LULC is crucial for environmental engineers, civil engineers, urban designers, and natural resources managers for planning activities.

Methods: TerrSet Geospatial Monitoring and Modelling System and ArcGIS Pro 2.8 were used to process LULC data for the region of the Lepelle River Basin (LRB) of South Africa. Driver variables such as population density, slope, elevation as well as the Euclidean distances of cities, roads, highways, railroads, parks and restricted areas, towns to the LRB in combination with LULC data were analysed using the Land Change Modeller (LCM) and Cellular-Automata Markov (CAM) model.

Results: The results reveal an array of losses (-) and gains (+) for certain LULC classes in the LRB by the year 2040: natural vegetation (+8.5%), plantations (+3.5%), water bodies (-31.6%), bare ground (-8.8%), cultivated land (-29.3%), built-up areas (+10.6%) and mines (+14.4%).

Conclusions: The results point to the conversion of land uses from natural to anthropogenic by 2040. These changes also highlight how the potential losses associated with resources such as water that will negatively impact society and ecosystem functioning in the LRB by exacerbating water scarcity driven by climate change. This modelling study provides a decision support system for the establishment of sustainable land resource utilization policies in the LRB.
Experts and national consultants’ recommendations regarding management of patients treated for migraine with comorbid depression. Diagnosis. Therapeutic strategies. Part 2
Authors: Stepień Adam , Słowik Agnieszka , Domitrz Izabela , Kozubski Wojciech , Rejdak Konrad , Rożniecki Jacek , Woroń Jarosław , Wachowska Katarzyna , Gałecki Piotr
Published: August 2021

Zaburzenia depresyjne są obecnie diagnozowane na podstawie kryteriów diagnostycznych ICD 10 (International Classification of Diseases) i DSM V (Diagnostic and Statistical Manual of Mental Disorders), obejmują osiowe objawy depresji i objawy dodatkowe, które muszę współwystępować przez co najmniej dwa tygodnie. Migrena diagnozowana jest na podstawie Międzynarodowej Klasyfikacji Bólów Głowy. Dzieli się zasadniczo na migrenę z aurą i bez aury, a ze względu na częstość napadów na migrenę epizodyczną i przewlekłą. Strategią terapeutyczną w leczeniu depresji jest stosowanie farmakoterapii w połączeniu z psychoterapią, natomiast w leczeniu migreny strategia zależy od częstości napadów bólu głowy (migrena epizodyczna vs migrena przewlekła) i od chorób współistniejących. W zakresie farmakoterapii zaburzeń depresyjnych leczenie pierwszej linii to leki z grupy z selektywnych inhibitorów wychwytu zwrotnego serotoniny (SSRI). Poszzczególni przedstawiciele tej grupy leków różnią się cechami charakterystycznymi co jest istotne przy indywidualnych decyzjach terapeutycznych. Pozostałe grupy obejmują inne leki. Nowością jest wprowadzenie do leczenia migreny przeciwciał monoklonalnych skierowanych przeciwko białku CGRP lub receptorowi dla tego białka istnieje wiele doniesień wskazujących na szczególną przydatność przeciwciał monoklonalnych modyfikujących działanie białka CGRP – w leczeniu migreny u chorych z depresją.
Home oxygen: guidance for transitioning from paediatric to adult care
Authors: Roots Debbie , Hernandez Tamsyn , Coverly Billie , Nzirawa Tendai , Lock Caroline
Published: August 2021

Transitioning from paediatric to adult care for home oxygen therapy can be confusing or even overwhelming for a child or young person. This guidance supports health professionals to make the transition as smooth and safe as possible, through the use of a checklist and questionnaire that aim to improve a child or young person's experience of care and outcomes.
Botulinum toxin treatment for difficult-to-treat finger pressure ulcers caused by severe hand flexion: case report
Authors: Takekawa Toru , Ikegaya Mariko , Etoh Takafumi , Shiio Yasushi , Sugihara Hiroshi , Haraikawa Keiko , Miyamoto Nozomi , Abo Masahiro
Published: August 2021

We report the successful treatment of two cases of difficult-to-treat pressure ulcers with botulinum toxin type A (BoNT-A). A 71-year-old male patient with Parkinson's disease presented with severe hand grip deformities of the fingers and a pressure ulcer (PU) on the right hand. He received 240U of BoNT-A into the upper limb muscles, which improved finger mobility during passive extension and resulted in resolution of the palm PU. No recurrence was noted. A 69-year-old female patient with Lewy body dementia presented with a PU on the palm side of the middle finger apex of the right hand, with exposure of the phalanx bone and dark red oedematous granulation of the tip of the finger. Severe muscle tone was noted. She received 240U of BoNT-A injected into the muscles of the upper extremities. This resulted in the disappearance of the contracture between the middle finger cusp and palm, and prompt healing of the PU. A protective finger orthosis was also used to improve hand finger grip and prevent further PUs. Although BoNT-A injection resulted in only slight improvement in the range of motion, it produced relief of pressure with consequent healing of the PU. Injection of BoNT-A into the affected muscles of the patients in this case report was effective in reducing flexor muscle tone, relief of pressure on the palm skin and healing of hand PUs.
Hard-to-heal wound treatment medical devices: clinical trial protocol in Japan
Authors: Matsuda Tatsuya , Ohura Norihiko , Mineta Koji , Ho Mami , Kaku I , Ishii Kensuke , Inoue Madoka , Ichioka Shigeru , Tanaka Rica , Kawamoto Atsuhiko , Terashi Hiroto , Kishi Kazuo , Kobayashi Yoko ,   The Guidance Development Committee for Clinical Trial Protocols for Chronic Wound Treatment Medical Devices
Published: August 2021

In consultation with academia and the Pharmaceuticals and Medical Devices Agency (PMDA), we have developed guidance for drafting protocols for clinical trials concerning medical devices for the healing of hard-to-heal wounds without ischaemia. The guidance summarises the validity of single-arm trials for hard-to-heal wounds, the definition of hard-to-heal wounds without ischaemia, methods of patient enrolment and clinical endpoints. This review focuses on the logical thinking process that was used when establishing the guidance for improving the efficiency of clinical trials concerning medical devices for hard-to-heal wounds. We particularly focused on the feasibility of conducting single-arm trials and also tried to clarify the definition of hard-to-heal wounds. If the feasibility of randomised control trials is low, conducting single-arm trials should be considered for the benefit of patients. In addition, hard-to-heal wounds were defined as meeting the following two conditions: wounds with a wound area reduction <50% at four weeks despite appropriate standards of care; and wounds which cannot be closed by a relatively simple procedure (for example, suture, skin graft and small flaps). Medical devices for hard-to-heal wound healing are classified into two types: (1) devices for promoting re-epithelialisation; and (2) devices for improving the wound bed. For medical devices for promoting re-epithelialisation, we suggest setting complete wound closure, percent wound area reduction or distance moved by the wound edge as the primary endpoint in single-arm trials for hard-to-heal wounds. For medical devices for improving the wound bed, we suggest setting the period in which wounds can be closed by secondary intention or a simple procedure, such as the primary endpoint.
Time-frequency analysis assisted determination of ruthenium optical constants in the sub-EUV spectral range 8 nm – 23.75 nm
Authors: Saadeh Qais , Naujok Philipp , Philipsen Vicky , Hönicke Philipp , Laubis Christian , Buchholz Christian , Andrle Anna , Stadelhoff Christian , Mentzel Heiko , Schönstedt Anja , Soltwisch Victor , Scholze Frank
Published: August 2021

The optical constants of ruthenium in the spectral range 8 nm – 23.75 nm are determined with their corresponding uncertainties from the reflectance of a sputtered ruthenium thin film, measured using monochromatized synchrotron radiation. This work emphasizes the correlation between structure modelling and the determined optical parameters in a robust inverse-problem solving strategy. Complementary X-ray Reflectivity (XRR) measurements are coupled with Markov chain Monte Carlo (MCMC) based Bayesian inferences and a quasi-model-independent method to create a model factoring the sample’s oxidation, contamination, and interfacial imperfections. The robustness of the modelling scheme against contamination and oxidation is tested and verified by measurements after hydrogen-radical cleaning of the sample’s surface.
Breaking voltage-bandwidth limits in integrated lithium niobate modulators using micro-structured electrodes: erratum
Authors: Kharel Prashanta , Reimer Christian , Luke Kevin , He Lingyan , Zhang Mian
Published: August 2021

This erratum contains a correction to Fig. 4 of Optica 8,
357 (2021)OPTIC82334-253610.1364/OPTICA.416155.
Using mobility data in the design of optimal lockdown strategies for the COVID-19 pandemic
Authors: Dutta Ritabrata , Gomes Susana N. , Kalise Dante , Pacchiardi Lorenzo
Published: August 2021

A mathematical model for the COVID-19 pandemic spread, which integrates age-structured Susceptible-Exposed-Infected-Recovered-Deceased dynamics with real mobile phone data accounting for the population mobility, is presented. The dynamical model adjustment is performed via Approximate Bayesian Computation. Optimal lockdown and exit strategies are determined based on nonlinear model predictive control, constrained to public-health and socio-economic factors. Through an extensive computational validation of the methodology, it is shown that it is possible to compute robust exit strategies with realistic reduced mobility values to inform public policy making, and we exemplify the applicability of the methodology using datasets from England and France.
Quantifying dose-, strain-, and tissue-specific kinetics of parainfluenza virus infection
Authors: Pinky Lubna , Burke Crystal W. , Russell Charles J. , Smith Amber M.
Published: August 2021

Human parainfluenza viruses (HPIVs) are a leading cause of acute respiratory infection hospitalization in children, yet little is known about how dose, strain, tissue tropism, and individual heterogeneity affects the processes driving growth and clearance kinetics. Longitudinal measurements are possible by using reporter Sendai viruses, the murine counterpart of HPIV 1, that express luciferase, where the insertion location yields a wild-type (rSeV-luc(M-F*)) or attenuated (rSeV-luc(P-M)) phenotype. Bioluminescence from individual animals suggests that there is a rapid increase in expression followed by a peak, biphasic clearance, and resolution. However, these kinetics vary between individuals and with dose, strain, and whether the infection was initiated in the upper and/or lower respiratory tract. To quantify the differences, we translated the bioluminescence measurements from the nasopharynx, trachea, and lung into viral loads and used a mathematical model together a nonlinear mixed effects approach to define the mechanisms distinguishing each scenario. The results confirmed a higher rate of virus production with the rSeV-luc(M-F*) virus compared to its attenuated counterpart, and suggested that low doses result in disproportionately fewer infected cells. The analyses indicated faster infectivity and infected cell clearance rates in the lung and that higher viral doses, and concomitantly higher infected cell numbers, resulted in more rapid clearance. This parameter was also highly variable amongst individuals, which was particularly evident during infection in the lung. These critical differences provide important insight into distinct HPIV dynamics, and show how bioluminescence data can be combined with quantitative analyses to dissect host-, virus-, and dose-dependent effects.
Chemical control and insecticide resistance status of sand fly vectors worldwide
Authors: Balaska Sofia , Fotakis Emmanouil Alexandros , Chaskopoulou Alexandra , Vontas John
Published: August 2021

Background

Phlebotomine sand flies are prominent vectors ofLeishmaniaparasites that cause leishmaniasis, which comes second to malaria in terms of parasitic causative fatalities globally. In the absence of human vaccines, sand fly chemical-based vector control is a key component of leishmaniasis control efforts.

Methods and findings

We performed a literature review on the current interventions, primarily, insecticide-based used for sand fly control, as well as the global insecticide resistance (IR) status of the main sand fly vector species. Indoor insecticidal interventions, such as residual spraying and treated bed nets are the most widely deployed, while several alternative control strategies are also used in certain settings and/or are under evaluation. IR has been sporadically detected in sand flies in India and other regions, using non-standardized diagnostic bioassays. Molecular studies are limited to monitoring of known pyrethroid resistance mutations (kdr), which are present at high frequencies in certain regions.

Conclusions

As the leishmaniasis burden remains a major problem at a global scale, evidence-based rational use of insecticidal interventions is required to meet public health demands. Standardized bioassays and molecular markers are a prerequisite for this task, albeit are lagging behind. Experiences from other disease vectors underscore the need for the implementation of appropriate IR management (IRM) programs, in the framework of integrated vector management (IVM). The implementation of alternative strategies seems context- and case-specific, with key eco-epidemiological parameters yet to be investigated. New biotechnology-based control approaches might also come into play in the near future to further reinforce sand fly/leishmaniasis control efforts.
Functional aspects of the Eustachian tube by means of 3D-modeling
Authors: Schuon Robert , Schwarzensteiner Josef , Paasche Gerrit , Lenarz Thomas , John Samuel
Published: August 2021

The extent of dysfunction of the Eustachian tube (ET) is relevant in understanding the pathogenesis of secondary otological diseases such as acute or chronic otitis media. The underlying mechanism of ET dysfunction remains poorly understood except for an apparent genesis such as a nasopharyngeal tumor or cleft palate. To better describe the ET, its functional anatomy, and the biomechanical valve mechanism and subsequent development of diagnostic and interventional tools, a three-dimensional model based on thin-layer histology was created from an ET in this study. Blackface sheep was chosen as a donor. The 3-D model was generated by the coherent alignment of the sections. It was then compared with the cone-beam computed tomography dataset of the complete embedded specimen taken before slicing. The model shows the topographic relation of the individual components, such as the bone and cartilage, the muscles and connective tissue, as well as the lining epithelium with the lumen. It indicates a limited spiraling rotation of the cartilaginous tube over its length and relevant positional relationships of the tensor and levator veli palatine muscles.