bluuebunny/crossref_metadata_2025 huggingface dataset:
URINARY TRACT INFECTIONS: A FOCUS ON TYPE 2 DIABETIC INDIVIDUALS
Authors: Parveen Nidha , Vijay Kavya , Ahamed Sheik Farhad , V V Adarsh
Published: December 2024

Urinary tract infections (UTIs) are more common, more severe, and carry worse outcomes in patients with Type 2 Diabetes Mellitus (T2DM)
compared to the general population. Diabetes Mellitus (DM) is a rapidly escalating global health issue, affecting millions worldwide, with an
increasing prevalence projected in the coming decades. Among diabetic individuals, the risk of UTIs is notably increased due to factors such as
impaired immune responses, reduced white blood cell function, poor blood circulation, bladder dysfunction linked to nephropathy, and glucosuria.
This heightened vulnerability leads to higher rates of complicated UTIs, including pyelonephritis, with a greater risk of organ damage, prolonged
hospitalization, and septic shock. Escherichia coli remains the most frequently isolated pathogen in UTIs, impacting both diabetic and non-diabetic
populations. UTIs are more prevalent in women, older adults, and those with higher body mass index (BMI), which complicates blood glucose
management in diabetic patients. Diagnosing UTIs in diabetics often relies on clinical evaluation, urine analysis, and urine cultures to confirm
bacterial presence and assess antibiotic susceptibility. Treatment for UTIs in patients with T2DM is guided by local antibiotic susceptibility
patterns and may include the use of first-line antibiotics such as nitrofurantoin, trimethoprim-sulfamethoxazole, or fosfomycin, depending on the
severity of the infection and the patient's clinical status. This review aims to explore the prevalence, risk factors, diagnostic approaches, treatment
strategies, and associated outcomes of urinary tract infections (UTIs) in individuals with Type 2 Diabetes Mellitus (T2DM), emphasizing the need
for enhanced clinical awareness and tailored interventions to mitigate complications and improve patient care.
BREAST MILK VS. INFANT FORMULA: A COMPREHENSIVE REVIEW OF NUTRITIONAL CONTENT, HEALTH OUTCOMES, AND PRACTICAL CONSIDERATIONS
Authors: Katiyar Keerti , Singh Shraddha , Yadav Sudipti , Verma Bindiya
Published: December 2024

Breast milk and infant formula are the two main sources of nutrition for infants, each with their own nutritional content, health effects, and practical
factors. Breast milk has been widely researched and demonstrated to have various benefits over infant formula. It provides vital nutrients and
bioactive components that help the infant's growth, immunological system, and cognitive development. Breast milk has been linked to a lower
incidence of infection, illness, and mortality when compared to infant formula. Furthermore, breast milk has been shown to have a good impact on
cognitive development, with studies demonstrating a significant improvement in cognition in premature newborns fed breast milk versus formula.
When nursing is not possible, infant formula is seen to be an effective alternative. It is intended to imitate the nutritional makeup of breast milk,
ensuring that infants' nutritional demands are met. However, it is crucial to note that infant formula may not give the same benefits as breast milk,
such as the presence of pituitary hormones. Studies have also revealed that breast milk's decreased protein percentage compared to infant formula
may have an impact on newborn growth and body composition. In practice, the decision between breast milk and infant formula may be influenced
by a variety of circumstances, including maternal and newborn health, as well as feeding preferences. While breast milk is frequently regarded as
the best source of nutrition for children, there are times when infant formula is required, such as when women are unable to nurse. It is critical to
ensure that infants get enough nutrients, whether they are fed breast milk or formula. Finally, breast milk and infant formula have distinct
nutritional properties, health consequences, and practical factors. Breast milk is widely considered the best source of nutrition for infants due to its
unique composition and benefits. When nursing is not possible, infant formula can provide important nutrients to support infant growth and
development.
A STUDY ON BACTERIOLOGICAL PROFILE AND ANTIMICROBIAL SUSCEPTIBILITY PATTERN OF STERILE BODY SITE INFECTIONS IN PATIENTS ATTENDING A TERTIARY CARE HOSPITAL
Authors: Bhowmik Shivalina , Kumari B Amrutha
Published: December 2024

Body fluids like cerebrospinal fluid, ascitic fluid, pleural fluid, bile, synovial fluids are free of microorganisms. If infection of the sterile body
compartment occurs, it can be life threatening which mandates early detection and antibiogram of organism. This study was aimed to evaluate the
bacterial aetiology and antimicrobial susceptibility pattern of isolates obtained from body fluids. This is a prospective study conducted in the
Department of Microbiology, MMC and RI. A total of 215 body fluid samples were studied. Samples were processed for aerobic bacterial culture
and identification was done according to standard procedures and antimicrobial susceptibility test was done using Kirby Bauer disc diffusion
method. Out of 215 samples, 43(20%) showed growth of organisms, of which 67.4% were Gram-negative and 32.6% gram-positive. Amongst the
Gram-negative isolates, Escherichia coli (34.5%;10/29) was the commonest and Staphylococcus aureus (42.8%;6/14) was the commonest among
gram positive organisms. All the gram-negative isolates were susceptible to colistin, followed by Carbapenems (48.3%;14/29), aminoglycosides
(37.9%;11/29) and monobactams (37.9%;11/29). 50% of the Staphylococcus aureus isolated were Methicillin resistant and all isolates were
susceptible to Linezolid and Vancomycin, in Enterococcus species isolated, 1 was Vancomycin resistant and 2 High level aminoglycosides
resistant. In this study, high resistance was observed with significant number of isolates which may lead to high morbidity and mortality, and this
mandates regular monitoring of prevalent pathogens and their antibiogram.
USE OF BUCCAL FAT PAD FOR RECONSTRUCTION OF ORBITAL FLOOR DURING SURGICAL RESECTION OF ADVANCED SINONASAL TUMORS - A CASE SERIES
Authors: Roy Sushobhan , Sarma Mridul Kumar , Missong Ajit Kumar , Choudhury Mrinmoy Mayur , Debnath Asim , Bagchi Debadeep
Published: December 2024

The orbital floor is formed by maxilla, palatine bone and orbital plate of zygomatic bone which supports the orbital contents. Deficiency in this
support are commonly caused by fractures of the orbital floor. Invasion of the orbital floor and periorbita by sinonasal tumors also warrants
resection of the orbital floor while resecting these tumors. The loss of support to the globe will cause enophthalmos, ophthalmoplegia and diplopia.
Many techniques have been described in the literature for the reconstruction of orbital floor like titanium mesh, autologous bone grafts and free
myo-osseous flaps, each having advantages and disadvantages of their own. In this case series of 5 cases we present our experience of using a
vascularized buccal fat pad for reconstruction of orbital floor after advanced sinonasal tumor resection. Buccal fat pad is a Summary/Conclusion:
easily available option for reconstruction of orbital floor. It has very little donor site morbidity and can potentially resist post operative
radiotherapy. Visual functions are preserved with its use. As it is an autologous flap, there is no fear of flap rejection or extrusion and gives
acceptable support to the orbital floor but has compromised cosmetic outcomes. Buccal fat pad can be considered a potential reconstruction
technique for limited orbital floor defects.
COMPARISON OF INCIDENCE OF PORT SITE INFECTION IN ENDOBAG VERSUS NON-ENDOBAG MEDIATED RETRIEVAL OF GALL BLADDER IN LAPAROSCOPIC CHOLECYSTECTOMY – AN OBSERVATIONAL STUDY
Authors: Pancholi Rakshit , Sethi Kapil , Kacker Nepash , Gupta Subodh
Published: December 2024

Background And Objectives: Existing literature provides some insights into the utility of endobag in laparoscopic cholecystectomy, still the
opinion is ambiguous about their clinical role in gall bladder retrieval in cholecystectomy. Most of the literature in this domain is from the western
world and very few empirical studies exist which address the findings in Indian sub-population. Therefore, to further our understanding about the
role of endobag in our setup and contribute to the limited pool of literature focussed on Indian subpopulation, we decided to conduct this study. The
aim of the study was to compare the incidence of port site infection in endobag versus non-endobag mediated retrieval of gallbladder in
laparoscopic cholecystectomy. The present prospective observational study was conducted in Departme Materials And Methods: nt of General
and minimal access surgery in Jaipur Golden Hospital. Participants were divided into two groups: the endobag group (Group A) and the nonendobag group (Group B) with 105 patients in each group undergoing laparoscopic cholecystectomy for acute calculus cholecystitis. All patients
were reviewed immediately after surgery and at the end of first, second and third week post operatively to evaluate port site infection. The Results:
study found a statistically significant difference in the incidence of Port site infection between the two groups. Group A demonstrated a lower
incidence of PSI compared to Group B. Specifically, the port site infection rate at week 1, week 2 and week 3 were 1.90% vs 8.57%, 2.85% vs 9.52%
and 0% vs 5.70% respectively for the endobag versus non-endobag groups, suggestive of statistically significant benefit associated with the use of
an endobag. Additionally, the use of an endobag was associated with a shorter duration of surgery & a shorter hospital stay. The port site spillage and
accidental perforation were also lower as compared to the non-endobag group. The use of an endobag f Conclusion: or gall bladder retrieval in
laparoscopic cholecystectomy significantly reduces the incidence of port site infections. The overall trend aligned with the major published
literature in this domain, both national and international. Findings of this study need to be validated further by larger studies in this domain
conducted in a more multicentric setting for the adoption of endobag-mediated retrieval as a standard practice to enhance patient outcomes in
laparoscopic cholecystectomy.
METASTATIC CARCINOMA ANORECTUM PRESENTING WITH ISCHIORECTAL ABSCESS AND FOURNIER'S GANGRENE 2 MONTHS AFTER CHEMO RADIATION
Authors: Goswami Rahul , Purohit Surendra , Songra Bhupen
Published: December 2024

Fournier's gangrene is necrotizing fasciitis of the genital and perineal soft tissues which can be due to various cutaneous, urogenital or colorectal
causes. Fournier's gangrene due to extra peritoneal perforation of rectal cancer is very rare. We report a rare case of a 47 years old gentleman,
diagnosed case of metastatic rectal adenocarcinoma with a history of chronic alcohol and tobacco use who presented to us with scrotal swelling,
erythema, and perianal pus discharge, accompanied by fever. Examination revealed extensive necrosis and crepitus in the perineal, scrotal, and
abdominal wall. Imaging and surgical findings confirmed extraperitoneal perforation of the rectal carcinoma with ischiorectal abscess and
Fournier's gangrene. After initial resuscitation, patient underwent emergency wound debridement, followed by a diversion colostomy. Despite
aggressive surgical intervention and intensive care Fournier's gangrene remains a life-threatening condition especially in immunocompromised or
cancer patients.
EVALUATION OF ANTIBACTERIALACTIVITY OF CEFTAROLINE AGAINST METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS IN A TERTIARY CARE CENTRE KERALA
Authors: K Paulose Anitta
Published: December 2024

The rising antimicrobial drug resistance of Staphylococcus aureus, particularly Methicillin-Resistant S. aureus (MRSA), poses significant clinical
challenges resulting in high mortality, lengthy hospital stays & higher bills. MRSA, defined by a minimum inhibitory concentration (MIC) of ≥4
μg/ml to methicillin has limited treatment options. Ceftaroline fosamil, a fifth-generation Cephalosporin is approved by USA Food & Drug
Administration for treating acute bacterial infections caused by MRSA, but research on its in-vitro efficacy is limited. This study conducted at
Department of Microbiology of a tertiary care centre, Kerala, evaluated antibacterial activity of Ceftaroline against MRSA. 50 MRSAisolates from
clinical specimens were tested for susceptibility to Ceftaroline. Methicillin resistance was confirmed via Kirby-Bauer method using 30μg cefoxitin
disc. Ceftaroline MICs were determined for 30 random MRSA isolates by using E-strips of Ceftaroline (Biomerieux). Isolates were classified as
ceftaroline susceptible (≤1μg/ml), Susceptibility Dose Dependent (SDD) (2-4μg/ml) & ceftaroline resistant (≥8 μg/ml) respectively as per CLSI
guidelines. Out of 30 isolates, 77% isolates were sensitive with MICs ranging from 0.125-2μg/ml, most common value being 0.25μg/ml & 16%
resistant & 7% in SDD category with MIC 2μg/ml. The study highlights Ceftaroline's strong efficacy against MRSA, supporting its use as a viable
treatment option.
TRANSFORMATIVE SHIFTS: ANALYZING EMERGING TRENDS IN INTERNATIONAL TRADE AND BANKING
Authors: Venkatesh S.
Published: December 2024

This research paper explores the transformative shifts in international trade and banking, examining historical evolutions
and current trends. It outlines how the development of trade and banking from ancient routes and early institutions to a
modern, interconnected system has shaped today's global landscape. Key emerging trends in international trade include the rise of digital
platforms, trade regionalization, supply chain resilience, sustainability initiatives, and technological advancements. Concurrently, the banking
sector is undergoing profound changes through digital banking, cryptocurrencies, open banking, sustainable finance, and advancements in AI and
cybersecurity. The integration of these trends enhances global commerce by fostering efficiency, sustainability, and innovation, while also
addressing challenges like regulatory issues and risk management.
CORRELATION OF STRENGTH OF ROTATOR CUFF WITH FUNCTIONAL OUTCOMES OF PATIENTS FOLLOWING ARTHROSCOPIC SHOULDER CUFF REPAIR – A COHORT STUDY
Authors: Mathews Henry , Nedumparampil Mevin Mathew , Kodi Harish , Sekaran Padmanaban , Krishnan Rinju , S Amaravathi Rajkumar
Published: December 2024

Background: Rotator cuff tears, with a prevalence of 20.7% in the general population, significantly impact daily activities and quality of life.
Arthroscopic rotator cuff repair (ARCR) is widely used due to its benefits in reducing post-operative pain and facilitating early rehabilitation. This
cohort study aimed to assess the correlation between the postoperative strength of the rotator cuff muscles and the functional outcomes post-ARCR.
Methodology: A total of 34 patients were evaluated, with 26 completing the study. Preoperative and six-month postoperative assessments included
isokinetic and isometric strength measurements, along with functional scores such as the Constant and American Shoulder and Elbow Surgeons
(ASES) scores. The results showed significant improvements in both strength and functional outcomes, Results: with the Constant score
increasing by 38 points and the ASES score by 53.8 points postoperatively. However, no significant correlation was found between the
improvement in rotator cuff strength and the functional outcome scores. The study highlights the effe Conclusion: ctiveness of ARCR in improving
both strength and functional outcomes, though it suggests that factors other than muscle strength may influence functional recovery
A RARE CASE OF SINONASAL LYMPHOMA
Authors: Upadhyay Manu , Tarani J. Sai , Yeslawath Nitishkumar
Published: December 2024

A 42-year-old male presented with an 8-year history of swelling in the right supraorbital area. Initial clinical evaluation raised concerns about
possible arterio-venous malformation or sinonasal mass, prompting a Contrast-Enhanced Computed Tomography (CECT) scan of the orbits.
Although rare, sinonasal lymphomas should be considered in cases of chronic, localized swelling in the orbital or paranasal regions, particularly
when symptoms persist despite standard treatments. Sinonasal lymphoma, often seen as extranodal NK/T- cell or diffuse large B-cell lymphoma,
may appear on imaging as a soft tissue mass with heterogeneous enhancement, sometimes accompanied by bone erosion or invasion of nearby
structures. Radiological features on CECT, such as the mass's enhancement pattern, help distinguish lymphoma from other sinonasal tumors or
vascular abnormalities. Ultimately, a combination of imaging, biopsy, and histopathology is essential for accurate diagnosis and guiding treatment
options.
LEARNING JEWELS: PARTIAL CARDIAC AUTOPSY – PATH LESS TRAVERSED
Authors: Kumar Singh Raveesh , Singh Sarika , Singh Meeta , Khuraijam Bembem
Published: December 2024

Background: There has been constant increase in the incidence of sudden deaths in elderly and young individuals, most of which has been due to
cardiac causes. Ischemic heart disease is the most attributed. To study the incidental cardiac lesio Objective: Material ns in cases of sudden deaths.
and Method: Autopsy records of the institute were scanned for cases with heart pathologies from January 2016 to June 2022. Twenty-two such
cases were retrieved and studied. Two cases showed autolytic changes thus were excluded. Haematoxylin and eosin-stained slides of total 20 cases
with special stains were studied in detail. Out of 20 cases studied, most common finding was myocardi Result: al infarction (MI), seen in eight cases
(40%). Dilated cardiomyopathy (DCM) was seen in two cases (10%), fatty infiltration was seen in two cases (10%), caseating epithelioid cell
granuloma, focal minimal interstitial fibrosis, focal pericardial fibrosis with sub pericardial fatty infiltration, intermyocardial edema and features of
electric shock was seen in one case each (5% each) . Three cases showed no cardiac abnormality. Thus Conclusion: , myocardial infarction is major
cause of sudden death and histopathological findings should be carefully studied in autopsy to prevent incorrect and inconclusive reports.
Investigate the SOD-1 gene variants rs4817415 and Their Relationship with the Physiological Antioxidant Index in Patients with T2DM
Authors: Al-Tamemi Zena Shakir , Hadi Suhad J. , Naji Hawraa H. , Kadhim Mustafa G. , Al-Shukri Hamzah. H. K.
Published: December 2024

Background and Aim: Type 2 diabetes mellitus (T2DM) is currently classified as a multi-gene hereditary metabolic disorder where the body fails to produce adequate insulin, resulting in irregular glucose regulation. Objectives: This research focuses on assessing the impact of SOD-1 gene variants rs4817415 and antioxidant index (AOI) in Iraqi individuals diagnosed with T2DM. Methods: A total of 90 participants, consisting of 45 individuals with T2DM and 45 healthy controls, were included in this study. The antioxidant index (TAO-C/MDA) was evaluated using the spectrophotometer method, while SOD-1 gene variants rs4817415 were analyzed through RT-RFLP. Results: The results of this study show that the T2DM and control groups had high statistically significant differences in TAO-C, MDA, and AOI levels (p-value < 0.05). The duration of T2DM in participants was strongly negatively correlated with TAO-C levels (r = -0.654), and it was significantly positively correlated with MDA levels (r = 0.412). According to the study's current findings, the AC hetrozygote genotype implied a statistically significant effect on the risk of type 2 diabetes (T2DM), with a P-value of 0.000 and an OR of 3.19 (1.56–3.09). Additionally, we discovered that the CC genotype and T2DM were significantly correlated, with OR= 1.45 (0.45-3.88). Additionally, the data indicated that the T2DM and CONT groups had statistically different distributions of SOD-1 gene variations, specifically (OR=3.11(1.12-4.09) rs4817415 and its alleles. Conclusion: The findings suggest that the SOD-1 gene variants rs4817415 may serve as a risk factor for the onset of T2DM and contribute to further complications in affected individuals.
Association of Serum C-Reactive Protein (CRP) with Acute Exacerbation of Chronic Obstructive Pulmonary Disease (COPD)
Authors: Barua Sudip , Towab Abu Md. , Chowdhury Fazlul Wahab , Bhowmik Goutom Chandra , Roy Haripada
Published: December 2024

Background: Chronic obstructive pulmonary disease consists of Chronic Bronchitis & Emphysema. It is persistent airflow limitation, usually progressive and associated with an enhanced chronic inflammatory response in the airways and the lung. The cause is tobacco smoking, occupational dusts, indoor and outdoor air pollutions. Objective: To find out association between serum C - reactive protein with acute exacerbation of Chronic Obstructive Pulmonary Disease. Methods: A Cross-sectional comparative study was carried out at Outpatient and inpatient department of Medicine and Respiratory unit of Z.H. Sikder womens Medical College & hospital, Dhaka, Bangladesh from 1 year (July-2020 to june-2021). A total number of 100 subjects of both sexes age range of 40-75 years who fulfilling inclusion and exclusion criteria & attending outpatient and inpatient departments of the Medicine and Respiratory unit of Z.H. Sikder womens Medical College & Hospital, Dhaka within the time frame. The study subjects were then divided into three groups Group I (AECOPD), Group II (SCOPD), and Group III (Control group). Results: A total number of 100 subjects of both sexes were included in this study in the age range of 40-75 years. Most of the subjects belong to 51-60- & 61-70-years age groups. The mean ages of group 1 were 59.4±9.0; group 2 was 59.4±6.7 and group 3 was 59.5±10.8 and the of total subjects' mean age was 59.5±8.4. Men had a higher prevalence of chronic obstructive pulmonary disease than women. In this study 85.4% of the patients of acute exacerbation of COPD were male and 14.6% were female. The ratio was 5.83:1. The common symptoms during exacerbation are increased dyspnoea (78%), increase cough (73%), increased sputum production (68%), change in sputum color (66%). The mean FEV1/FVC ratio in percentage was 45.5±9.7% in AECOPD; 68.5± 9.7% in stable COPD. The mean value of serum CRP was 16.9±4.4 in AECOPD (group-1); 10.9±3 in stable COPD (group-2) and 5.1±1.7 in case ...
Angiomas of the Liver Compressing the Bile Duct: A Rare Cause of Obstructive Cholestasis
Authors: Achraf Bahi , Aziz Fadili M. , Ibrahim Zouhry , Abdelilah Hamada , Mustapha Halim El , Abdelmounaim Ait Ali
Published: December 2024

Hepatic angiomas, the most common benign tumors of the liver, are generally asymptomatic. However, their location or size can lead to rare complications such as bile duct compression. We report the case of a 35-year-old woman presenting with cholestatic jaundice secondary to a compressive hepatic angioma. The diagnosis was confirmed by magnetic resonance imaging. This case highlights the diagnostic and therapeutic challenges associated with this rare pathology and underscores the importance of multidisciplinary management.
Short Term Outcomes of Fistulectomy with Primary Closure of Internal Opening for the Treatment of High Trans-sphincteric Fistula in Ano
Authors: zaman Dr. Md. Asaduz , Hossain Dr. Md. Shahadat , Fatima Dr. Tasnim , Jalal Dr. Mohammed Tanvir , Taher Dr. Md. Abu , Muhammed Dr. Shafayat , Hasan Dr. Md. Mahmudul , Barai Dr. Shyamal Chandra
Published: December 2024

Background: Fistulectomy with primary closure of the internal opening has been used to treat high trans-sphincteric fistula in ano. This method entails complete removal of the fistula tract from external opening to internal opening and closing the internal opening from the inside of anal canal. This study aims to assess the outcomes of fistulectomy with closure of the internal opening for high trans sphincteric fistula. Methods: Observational study was carried out in the Department of Colorectal Surgery, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh. Total 36 patients with high trans sphincteric fistula were included in this study. After preoperative MRI of anorectum, fistulectomy with closure of the internal opening was done. Results: The mean age was found 39.4 years with range from 20 to 57 years. Among 36 patients, 83.3% patients had primary wound healing within 6 weeks and rest of the patients healed within 10 weeks. Clinical squeeze pressure was reduced in 11.1% patients. Thirty two patients were available for 1 year follow up. Recurrence occurred in 21.88% (n=32) patients within the study period. 91.7% patients had Park-Brown continence grade-A and 8.3% had grade-B. Wound infection did not impair postoperative continence (p>0.05). There was statistically significant difference between wound infection and suture line dehiscence with fistula recurrence (P<0.05). Conclusion: Since the recurrence and incontinence rate were low, clinical squeeze pressure did not significantly reduced along with quick healing rate, fistulectomy with closure of the internal opening is an effective treatment option for high trans-sphincteric fistula in ano.
Giant Pleural Solitary Fibrous Tumor Revealed by Superior Vena Cava Syndrome: A Case Report
Authors: Chaanoun K. , Zaghba N. , Benjelloun H. , Yassine N.
Published: December 2024

Introduction: Solitary fibrous tumors are rare mesenchymal tumors, often benign, of pluripotent fibroblastic or myofibroblastic origin. They usually develop at the expense of the pleura, but they can be localized to any organ. Clinical observation: we report the case of a 50-year-old patient who was admitted to the department for a superior vena cava syndrome revealing a giant thoracic tumor. The biopsy of the mass was in favor of a pleural solitary fibrous tumor. Discussion: The etiopathogenesis of the disease is unclear, but it could be related to accumulated somatic mutations, including the NAB2-STAT6 fusion, TP53 mutations and TERT promoter mutations. Conclusion: The diagnosis of a pleural solitary fibrous tumor is confirmed by histology after biopsy or surgical excision. The prognosis depends on the size of the mass, the mitotic index, and the presence or absence of necrosis.
Characteristics of Extra Thoracic Sarcoidosis: A Retrospective Study from Morocco
Authors: Abdelhalim Boucaid , Sara Baziaa , Ali Grine , Amine Belghiti , Hicham Balkhi , Ismail Rhorfi Abderahmane
Published: December 2024

Background: Sarcoidosis is a multisystem granulomatous disorder with diverse extra thoracic manifestations requiring systematic evaluation. Objectives: To analyse the characteristics and outcomes of extra thoracic manifestations in sarcoidosis patients at Mohamed V Military Hospital, Rabat. Methods: Retrospective study of 54 sarcoidosis patients from January 2021 to January 2024. Clinical, biological, radiological, and therapeutic data were analysed. Results: Extra thoracic involvement occurred in 16 patients (30%), predominantly female (sex ratio 1/3), mean age 41±7 years. Type II radiographic sarcoidosis was most common (50%). Main manifestations were ocular (16.6%), peripheral lymph nodes (9.25%), and cutaneous (7.4%). Biological findings included elevated ACE (20.4%), leukopenia with lymphopenia (7.4%), and hypercalcemia (3.7%), Treatment comprised corticosteroids (75%), immunosuppressants (12.5%), and antimalarial drugs (12.5%). Conclusion: Extra thoracic sarcoidosis presents diverse manifestations requiring vigilant screening. Treatment strategies primarily rely on corticosteroids, with favourable outcomes in most cases.
Protein S Deficiency Revealed by Locked-In Syndrome: A Case Report
Authors: Ali Grine , Amine Belghiti , Mohamed Abdelaoui , Noureddine Kartite , Abdelghafour Elkoundi , Naoufal Doghmi , Hicham Bakkali
Published: December 2024

Locked-in syndrome (LIS) refers to patients with tetraplegia and lower cranial nerve paralysis but with intact consciousness. The main etiology of this syndrome is pontic ischemic stroke, but it may also be secondary to other less common mechanisms. We report the unusual case of a patient with a Locked-in syndrome following basilar arterial thrombosis related to protein S deficiency highlighting the key role of thrombophilia assessment to help with generally difficult diagnosis.
Laparoscopic Management of Synchronous Ascending Colon Adenoma and Gastric Gastrointestinal Stromal Tumor (GIST)
Authors: Leandro Sofia , Matias Inês , Bolota Joana , Leandro Rita , Caldeira Beatriz , Silva Artur Canha , Carvalho Manuel
Published: December 2024

Synchronous tumors are rare occurrences that present unique diagnostic and surgical challenges. This article discusses the case of a 61-year-old male patient with a synchronous adenoma of the ascending colon and gastric gastrointestinal stromal tumor (GIST). The patient underwent successful laparoscopic right hemicolectomy and atypical gastrectomy with an uneventful recovery. This report highlights the diagnostic approach, operative strategy, and pathological findings, emphasizing the importance of a multidisciplinary approach for managing such complex cases [1-3].
Dedifferentiated Liposarcoma of Kidney: A Rare Entity
Authors: Tbouda M. , Mery A. , Aggouri H. , Toufga Z. , Jendouzi O. , Abbaoui S.
Published: December 2024

Liposarcoma is an uncommon mesenchymal tumor. There are several histological variants. Dedifferentiated liposarcoma is often located retroperitoneally. Renal localization is exceptional. In this article, we report a case of primary renal dedifferentiated liposarcoma treated by radical total nephrectomy. Imaging assessment suspected a malignant tumor. It was the histological examination with an immunohistochemical complement that confirmed the diagnosis of dedifferentiated renal liposarcoma. The prognosis remains poor.
“Janganlah Kamu Disebut Rabi”: Sebuah Pendekatan Hermeneutik-Pedagogis terhadap Matius 23:8
Authors: Saragih Erman Sepniagus
Published: December 2024

Matius 23:8 merupakan teks yang rumit dan sarat dengan hal-hal kontroversial. Perbandingan prinsip pengajaran Yesus dan pengajaran para rabi Yahudi yang tersebar luas di balik teks-teks Matius harus jelaskan, sebab sangat bermanfaat untuk memaknai maksud teks. Mengabaikan tugas mengajar ahli Taurat dan orang Farisi dalam Matius 23:8 dapat menghasilkan distorsi penafsiran, bahkan salah menggali makna teks Alkitab. Esai ini memberikan perspektif baru atas pembacaan larangan Yesus “janganlah kamu disebut Rabi” dalam Matius 23:8 dengan menggunakan Hermeneutik pendekatan pedagogis. Tujuan penelitian ini adalah untuk memahami dan mengartikulasi mengapa Yesus melarang para murid dan orang banyak disebut Rabi dan bagaimana hal ini dibaca dengan lensa pedagogis. Kesimpulan dalam penelitian ini adalah pertama, terjadi diakognisi makna kata rabi dalam ajaran Yesus. Kedua, pengajar tidak bermuara pada tujuan untuk kedudukan dan penghormatan (prestise). Ketiga, Yesus sedang mengajarkan prinsip yang mengedepankan sikap persaudaraan yang saling melayani dengan pandangan bahwa Yesus satu-satunya Guru. Artinya, Dialah yang layak menerima kemulian dan hormat sampai selama-lamanya.
REABILITAÇÃO PÓS-CIRURGIA PARA CÂNCER DE BEXIGA: DESAFIOS E AVANÇOS.
Authors: Nascimento Maria Eduarda Bezerra do , Pereira Da Silva Filho Antônio , Seabra Carvalho Milena , Souza de Alcântara Maria Noêmia , Morais Brito Ana Clarisse , Souza Azevedo Thiago , Ray de Andrade Silveira Italo , Abritta Mariquito Maria Fernanda , De Souza Gonçalves Lorhany , Maria Esteves Rocha Yasmin , Araújo de Freitas Cavalcante Maryane Francisca , Da Silva Lessa Mariano Lethícia
Published: December 2024

A reabilitação pós-cirurgia para câncer de bexiga é um processo complexo que envolve desafios físicos, emocionais e sociais, mas também apresenta avanços significativos. Este estudo realizou uma revisão integrativa da literatura, analisando estratégias e inovações aplicadas ao cuidado de pacientes submetidos à cistectomia radical. Os resultados destacam que intervenções como fisioterapia pélvica, suporte nutricional, programas educativos e o uso de tecnologias, como monitoramento remoto e cirurgia robótica, têm contribuído para a melhoria da qualidade de vida e redução de complicações. Apesar dos progressos, ainda há lacunas no acesso equitativo aos cuidados e na avaliação de impactos de longo prazo, evidenciando a necessidade de políticas públicas que promovam uma abordagem interdisciplinar e humanizada.
O impacto do treinamento multiprofissional em emergências
Authors: Barros Sarah Silva Costa , Costa Fabio da Silva , Araújo Anne Vitória Cavalcante , Lima Agda Barbosa , Barroso Thayanara Nicoly Silva , Pinheiro Francisco Yure Soares , França Amanda  Raissa de Sousa , Rodrigues Erica Ludimila Lopes , Santos Amanda Ferreira dos , Silva Ana Paula Stefanelo e , Santos Sthefany Bezerra dos , Almeida Júlia Bobato Ramos de
Published: December 2024

Introdução: Nas Unidade de Terapia Intensiva, o cuidado aos pacientes depende de equipes multiprofissionais compostas por médicos, enfermeiros, fisioterapeutas, farmacêuticos, entre outros. Cada profissional desempenha um papel específico, complementando o trabalho dos demais. A gestão de emergências em terapia intensiva requer atuação coordenada de equipes multiprofissionais. Treinamentos periódicos têm sido apontados como ferramentas fundamentais para otimizar o desempenho em situações críticas.  Objetivo: Este artigo busca analisar o impacto do treinamento multiprofissional em emergências em UTIs, destacando sua influência nos desfechos clínicos dos pacientes e na eficácia do trabalho em equipe. Método: Este estudo trata-se de uma revisão de literatura com abordagem qualitativa e quantitativa.  A pesquisa foi realizada em bases científicas como Medline, Lilacs e BDENF, utilizando descritores: " Tutoria", "Emergências", " Unidades de Terapia Intensiva" e " Avaliação de Resultados em Cuidados de Saúde" e na literatura cinzenta.  Resultados e Discussão: Os estudos analisados demonstraram que treinamentos multiprofissionais aumentam a eficácia da comunicação, diminuem o tempo de resposta a emergências e reduzem complicações, como parada cardiorrespiratória. Esses impactos resultaram na redução da mortalidade e na melhoria da satisfação dos profissionais e pacientes.  Conclusão: Treinamentos multiprofissionais são essenciais para otimizar o atendimento em emergências, ressaltando a necessidade de implementação de programas regulares e avaliativos em UTIs.
Análise e conduta de exacerbação da Asma pediátrica
Authors: Sbardella Simone , Souza Alex Moreira
Published: December 2024

O presente artigo busca analisar as diferenças de duas das fundamentais diretrizes (Global Initiative for Asthma - GINA e British Guideline on the Management of Asthma – BGMA da British Thoracic Society - BTS) e equipará-las em um resumo proposital a fim de auxiliar profissionais da equipe de saúde na prática clínica do dia a dia.
Pengaruh Digital Leadership Terhadap Kreativitas Dan Dampaknya Pada Kinerja Karyawan Milenial: Peran Leader Member Exchange
Authors: Yolanda Debora Icha Ester , Yulianti Emma
Published: December 2024

Penelitian ini bertujuan untuk mengetahui pengaruh variabel kepemimpinan digital terhadap variabel tingkat kreativitas karyawan milenial di Jawa Timur dan dampaknya terhadap kinerja karyawan. Selain itu, penelitian ini juga mempertimbangkan peran moderasi Leader-Member Exchange (LMX) dalam mengelola hubungan antara pemimpin dan anggota tim. Metode dalam penelitian ini menggunakan pendekatan kuantitatif dengan pengumpulan data melalui kuesioner yang disebar kepada 179 karyawan milenial di berbagai industri di Jawa Timur. Penelitian ini menggunakan teknik analisis Structural Equation Modeling (SEM) menggunakan SmartPLS yang bertujuan untuk menguji hubungan antar variabel, baik antar variabel laten maupun dengan variabel indikator. Hasil nilai Uji-T melalui nilai T-Statistik sebesar 1,421 dengan P-Value sebesar 0,155 membuktikan bahwa variabel LMX tidak memoderasi hubungan antara kreativitas karyawan dengan kinerja karyawan, sehingga saran untuk penelitian selanjutnya dapat mengubah variabel LMX menjadi variabel mediasi untuk variabel lain.
Analisis Pengaruh Kepercayaan, Keamanan, dan Kualitas yang Dirasakan terhadap Keputusan Pembelian Produk di Aplikasi Shopee
Authors: Aulia Tasfiyah , Ronny Ronny
Published: December 2024

Di masa kemajuan era digital saat ini perkembangan teknologi internet begitu pesat. Hal ini mengubah cara pandang, cara kerja, dan segala bidang termasuk dalam hal belanja online. Penelitian ini bertujuan untuk menguji pengaruh kepercayaan, keamanan, dan kualitas yang dirasakan terhadap keputusan pembelian. Sampel terdiri dari 129 responden yaitu pelanggan Shopee yang memiliki karakteristik minimal berusia 19 tahun dan pernah melakukan pembelian di Shopee. Penelitian ini menggunakan analisis Structural Equating Modelling (SEM) pada Partial Least Square (PLS) dan menggunakan penyebaran kuesioner dalam bentuk google form untuk pengumpulan data. Hasil penelitian ini menunjukkan bahwa adanya pengaruh yang signifikan positif kepercayaan terhadap keputusan pembelian. Penelitian ini menunjukkan adanya pengaruh yang signifikan positif keamanan terhadap keputusan pembelian. Hasil terakhir dari penelitian ini yaitu kualitas yang dirasakan juga berpengaruh signifikan posistif terhadap keputusan pembelian.
Influence of Memorable Culinary Experience on Revisit Intention Mediated by Place Identity in Semarang
Authors: Kodriyah Laela , Putra Harmanda Berima
Published: December 2024

This research aims to examine the influence of memorable culinary tourism experiences on revisit intention directly and indirectly through the mediating role of place identity. The research method used is a quantitative method. A sample of 162 people was obtained through the use of a purposive sampling method which took into account certain characteristics in the collection process. The data collection technique in this research is a questionnaire in the form of a Google Form. data analysis using Structural Equation Modeling Smart PLS. The results showed that a memorable culinary tourism experience has been proven to have a positive influence on place identity, however, place identity has not been proven to have a positive influence on revisit intention and there is no proven mediating role for place identity.
Analysis of the Effect of Foreign Workers on Unemployment in Banten Province
Authors: Muchlis Aditia , Fiqhi Afif , Mumtazah Liza
Published: December 2024

The purpose of this research is to analyze issues related to unemployment influenced by foreign workers in Banten Province. The specific objective is to deepen the study related to strategic efforts to increase government capacity to improve the quality of human resources in overcoming unemployment in Banten Province. This research uses a qualitative method based on a combination of primary and secondary data processing conducted using a discourse analysis approach. Data collection methods used in this research are interviews and documentation, in addition to discussions related to strengthening field data. Based on the discussion that has been explained above, the researcher draws the conclusion that foreign workers do not have a significant impact on unemployment in Banten Province; knowlage transfer is needed and becomes a priority scale rather than profit sharing; work ethic is an important asset that must be owned by job seekers and those who are already working.
Peran Brand Image: Pengaruh Celebrity Endorsement, E-WOM, dan Perceived Quality terhadap Purchase Intention Skincare pada Gen-Z
Authors: Fahlevi Renza , Helen Helen , Sinambela Fitriana Aidnilla
Published: December 2024

Studi ini bertujuan untuk mengeksplorasi dampak Celebrity Endorsement dari sisi Attractiveness, Trustworthiness, dan Expertise, E-WOM, dan Perceived Quality terhadap Purchase Intention produk skincare lokal di kalangan konsumen Gen Z dengan Brand Image sebagai mediasi. Penelitian ini menerapkan pendekatan kuantitatif dan metode eksplanatori.  Sampel dipilih dengan teknik purposive dalam metode non-probabilitas. Data dikumpulkan melalui survei kuesioner dan berhasil terkumpul 300 responden. Data yang diperoleh akan dianalisis menggunakan SmartPLS dan SPSS. Hasil penelitian mengungkap bahwa E-WOM dan kredibilitas celebrity endorsement memiliki dampak positif signifikan terhadap brand image skincare lokal di kalangan Gen Z. Perceived quality dan brand image juga berperan secara signifikan dalam meningkatkan purchase intention. Selain itu, ditemukan bahwa brand image memainkan peran sebagai perantara dalam hubungan antara E-WOM dan celebrity endorsement, yang pada akhirnya meningkatkan purchase intention skincare lokal di kalangan konsumen Gen Z.
Conventional Paths of Transmission of Monetary Policy: An Introduction
Authors: Praveen Kumar  , Dr. Mahendra Ranawat
Published: December 2024

Since, the advent of new economic reforms (1991), the India has witnessed a significant rise in its growth. The process through which the changes are made in the monetary policy, influences the various macroeconomic variables like growth and inflation, is called as Monetary Policy Transmission Mechanism. Therefore, a deep knowhow (understanding) of the working of the various modes of monetary transmission becomes necessary for the efficient and effective functioning of Monetary Policy. The current paper explains the conventional paths of monetary transmission e.g. the interest rate path, the exchange rate path, the credit path (the bank lending path and the balance sheet path), the asset price path and the expectations path. The objective of this paper is to improve the understanding about the existing paths of the transmission mechanism of monetary policy subject to available literature. This will further provide basis for the future research in the area of the monetary economics to the interested researchers. This paper has used the literature from 1991 to 2022 for this purpose.
Ascorbic Acid Supplementation on D-dimer Levels in COVID-19 Patients
Authors: Digambiro Reza Aditya , Setyaningrum Dyah Ayu Woro , Ilona Florinda , Chendrasari Julian , Lestari Indah Widya , Muhammad Nanda Noor
Published: December 2024

Background: D-dimer is a potential biomarker for COVID-19 severity, correlated with the clinical outcomes and radiological findings. This research investigates the effect of ascorbic acid, an antioxidant and immunomodulator, on D-dimer levels in COVID-19 patients. Methods: The research design is prospective, randomized controlled, and conducted from January to March 2021 at Rumah Sakit Umum Daerah Tebet, Jakarta. Overall, 150 confirmed COVID-19 patients were randomized into two groups using a computer-generated block randomization technique. The intervention group received high-dose ascorbic acid (2 grams orally every 6 hours for seven days), while the control group received a placebo. Outcomes were assessed in changes in D-dimer levels, clinical severity, and radiological abnormalities. Statistical analyses included the Mann-Whitney, Wilcoxon signed-rank test, and logistic regression. Results: The patients treated with ascorbic acid showed a significant reduction in D-dimer levels compared to the placebo group. Additionally, these patients demonstrated notable improvements in clinical severity and radiological outcomes. The Wilcoxon signed-rank test demonstrated significant reductions in D-dimer levels within the ascorbic acid group (p < 0.001) and significant increases within the placebo group (p < 0.001). Conclusion: Ascorbic acid supplementation was associated with lowered D-dimer levels in COVID-19 patients, pointing to its potential therapeutic benefits in moderating disease severity. These results strongly support further research into ascorbic acid's benefits during COVID-19, especially for those at increased risk of severe disease progression.
Evaluation of Body Mass Index as a Marker for Monitoring of Intensive Phase Therapy and Vitamin D Supplementation in Pulmonary TB
Authors: Ni Nyoman Ariwidiani  , Nurul Hadiatun  , I Wayan Getas
Published: December 2024

Background: In 2022, the success rate of tuberculosis (TB) treatment in Indonesia was 86.50%, which was below the 90.00% target. The decline in nutritional status among TB patients can result from anorexia, leading to inadequate nutrition. In TB patients, the intensive phase of treatment carries a risk of 3,021 times greater for developing malnutrition. It is associated with delayed healing, increasing the risk of death and TB recurrence. This study aimed to observe changes in body mass index (BMI) in TB patients as a marker for measuring the success of the treatment. Methods: This analytical experimental study used a one-group pre-test and post-test design, applying a purposive sampling method. The study sample included all patients diagnosed with TB who met the inclusion and exclusion criteria, with a minimum sample size of 15. Results: As many as 15 new patients were diagnosed with pulmonary TB. Height and weight measurements were taken to determine their BMI. Most respondents had a BMI below normal before therapy, with 6 people (40.00%) classified as thin. After receiving anti-TB drugs and vitamin D therapy for 2 months of intensive treatment, this number decreased to 2 people (13.30%). Results from the paired t-test showed a p-value of < 0.001, indicating a statistically significant difference in nutritional status before and after two months of anti-TB drug and vitamin D therapy. Conclusion: Changes in BMI were observed in pulmonary TB patients after receiving the anti-TB drug therapy and vitamin D for two months during the intensive phase.
Age and Work Region's Association with Stress, Depression, Anxiety in Tourism Workers Amid Covid-19
Authors: Putu Indah Budi Apsari  , Anak Agung Sagung Ayu Tribhuwana Wulan Nadarin  , Made Indra Wijaya
Published: December 2024

Background: World Health Organization in 2020 mentioned that there were around 35 million people affected by depression and according to Perhimpunan Dokter Spesialis Kedokteran Jiwa Indonesia (PDSKJI), there were around 67.00% of tourism employees affected by depression caused by the COVID-19 pandemic. This research aimed to analyze the association of age and work region with the severity of stress, depression, and anxiety in tourism workers during the COVID-19 pandemic. Methods: This cross-sectional study took place in Bali Province from July to August 2023. Depression, Anxiety and Stress score (DASS) was used for the questionnaire in this research. Subjects were recruited using convenience sampling. Results: A total of 138 respondents who filled out the questionnaire in Google Forms automatically became research samples. The data was analyzed using Pearson's Chi-square test to identify the association between the variables.  Depression, anxiety, and stress dominated by 20-29 years old. There was a statistically significant association between age, work region, and the severity level of depression, anxiety, and stress (p < 0.001). Conclusion: age and work region are associated with severity levels of depression, anxiety, and stress.