bluuebunny/crossref_metadata_2025 huggingface dataset:
Recent Innovations in Artificial Intelligence (AI) Algorithms in Electrical and Electronic Engineering for Future Transformations
Authors: Sureshraj S. P. , Duraisamy Nalini , Palaniappan Rathi Devi , Sureshkumar S. , Priya M. , Britto Pitchai John , Badcha Yakoob Mohamed , Karthikeyan S. , Sundarajan G. , Muthuveerappan S.
Published: September 2023

This chapter explores recent Artificial Intelligence (AI) innovations in core
engineering domains, especially in Electrical and Electronics Engineering. The major
grounds for these innovations arise due to the engineer's work toward the forefront
innovative technologies, by contributing in research, design, development, testing, and
manufacturing of next-generation equipment. The Electrical and Electronics
Engineering expands its research and development methodology in applications with
artificial intelligence subsets such as machine learning, deep learning, and data science
algorithms. This as an upshot made an industrial revolution 4.0. In the evolution of new
generation areas of research and development, which are discussed in this chapter, AI
algorithms are implemented in the field of power systems, power electronics, smart
grids, and renewable energy technologies. The experimental verification for these
innovations has been executed using Matlab/Simulink design environment.
An Introduction to Diabetes Drug Discovery in Biomedical Industry through Artificial Intelligence, Using Lichens' Secondary Metabolites
Authors: Rajaprabu N. , Ponmurugan P.
Published: September 2023

Proven history in science shows that natural products play a vital role in
drug discovery, specifically for immune deficiencies, infectious diseases, and other
therapeutic areas, including cardiovascular diseases and multiple sclerosis. Monk
Agastyar and Pandit Ayothidhas contributed more to the field of Siddha through mono and polyherbal medicine and cured many diseases, including oxidative stress and
diabetes. Using computational and analytical intelligence methods, this study aims to
develop a natural phycobiont (lichens) edible source of metabolites for the chronic and
metabolic disorder type II diabetes. The level of docking was ranked based on the
iGEMDOCK grading function, with zero being the most accurate ligand. Ultimately,
each complex from each fungus that ensured different binding pockets of the 6AK3 had
been designated throughout the virtual screening process. Based on the uppermost
energy value, the best compounds from each fungus showed accurate molecular
docking. Out of the 22 compounds tested, the anthracene-9-one and acetamide found in
R. conduplicans showed a high binding capacity. Meanwhile, the binding energy
potential of M-Dioxan-4-ol, 2,6-dimethyl, obtained from X. curta, and 2-Chloroethyl
Methyl Sulfoxide, obtained from M. fragilis, was enormous. 3, 4-13, 14-dodecahydr-18,18a-dihydroxy-2-methyl-, and 1,4-Bis (trimethylsilyl) benzene were all found in P.
reticulatum.
Artificial Intelligence Based Global Solar Radiation Prediction
Authors: Rajasekaran Meenal , Ekambaram Rajasekaran
Published: September 2023

Solar energy is one of the cleanest renewable energy sources and has no
environmental impact. Solar radiation data is important to solar engineers, designers
and architects which is also fundamental for efficiently determining irrigation water
needs and potential yield of crops, among others. Solar energy is mainly used to meet
the growing electricity demand and decline the amount of CO2
emission thus
preserving fossil fuels and natural resources. The temperature and sunshine duration
are measured by most of the meteorological services all over the world but global solar
radiation measurements are limited due to the restricted number of solar radiation
measuring stations and some of the data are missing. In order to estimate the solar
radiation in the other areas where the meteorological stations are not established, the
theoretical solar radiation estimation models proposed by various researchers have
proved handy. One of the main important assignments is to recognize the site with high
solar energy potential for renewable power generation. This assists in accomplishing
the target of the Indian solar mission project by the year 2022. The present work aims
at the prediction of solar radiation using artificial neural network models which are
applied to four different locations across India. As validation, measured and estimated
solar radiation data were analyzed in terms of the square of the correlation coefficient
and RMSE. The outcomes of this study will play a vital role in the estimation of global
solar radiation with less percentage of error.
In silico Approaches to Tyrosine Kinase Inhibitors’ Development
Authors: Sugunakala S. , Selvaraj S.
Published: September 2023

Many cellular communications and cellular activities are regulated by a class
of enzyme tyrosine kinases. Mutations or increased expression of these enzymes lead to
many proliferative cancers as well as other non-proliferative diseases such as psoriasis,
atherosclerosis and some inflammatory diseases. Hence, they are considered vital and
prospective therapeutic targets. Over the past decade, considerable research work has
been carried out to develop potential inhibitors against these tyrosine kinases. So far, a
number of compounds have been identified successfully as tyrosine kinase inhibitors
and many compounds were developed as drugs to treat tyrosine kinase-induced
diseases. Behind the successful development of these inhibitors, many Computer Aided
Drug Design (CADD) (in silico) approaches include molecular modelling, high
throughput virtual screening against various chemical databases, and docking (both
rigid and flexible method of docking). Further many studies identified the possible
features which are responsible for tyrosine kinase inhibition activities for a number of
series of compounds through the quantitative structure-activity/property relationship
(QSAR/QSPR) process. In this review article, the structural characteristics, mechanism
of action, and mode of inhibition of tyrosine kinases are discussed followed by the
successful applications of a variety of in silico approaches in tyrosine kinase inhibitors
development.
Artificial Intelligence-genomic Studies in The Advancement of Agriculture
Authors: Ushasri R. , Rafiq Summera , Shahina SK. Jasmine , R. Lakshmi P. Priyadarshini
Published: September 2023

Artificial Intelligence in agriculture biology plays a vital role in the
improvisation of crop production and enhances resistance against plant pathogens.
Artificial intelligence brings about changes in crop production by predicting the gene
data, showing the ability of plants to resist plant pathogens and environmental
conditions. Machine learning methods, namely artificial, neural, and Deep Neural
networks. Computational approaches were used to determine Plant Genomics. The
main aim of this review study was to understand plant genomics data, predict plant
genomes based on machine learning and reduce the cost of fertilizers and side effects.
The seven important factors include soil moisture, the electric conductivity of soil
solution, evapotranspiration, humidity, soil aeriation, and soil pH and air temperature.
The red, green, and infrared channels of sensors in three layers of ANN were used for
the determination of genomic data. Chemical fertilizers are used to kill pests damaging
crops and affecting the ecosystem. Farmers and agricultural scientists are looking
forward to implementing advanced machine learning techniques such as sensors
mounted on vegetable and fruit orchards. The traps were manufactured and installed by
using sensors to detect parasites infecting crops of agricultural importance. This review
study was focused on computational data on plant genomics and promoting less usage
of fertilizers to prevent carcinogenic and genomic diseases. The researchers performed
an experiment and stated that eight master transcription factors are the most vital to
enhance the ability to fix nitrogen from the atmosphere. Farmers are future artificial
intelligence Engineers. Based on the review of the literature, it was evident that
artificial intelligence enhances crop improvement for better productivity.
Functional Prediction of Anti-methanogenic Targets from Methanobrevibacter Ruminantium M1 Operome
Authors: Bharathi M. , Saranya S. , Kumar N. Senthil , Chellapandi P.
Published: September 2023

Methanobrevibacter ruminantium M1 is one of the abundant methanogenic
archaea found in ruminants, which is influential in livestock production by enteric
methane emission. Several methane mitigation strategies have been employed to curtail
enteric methane emissions, most of which have not been successful to date. Hence, it is
imperative to discover new targets for the development of organism-specific vaccines
and inhibitors of methanogenesis. In this study, we predicted the functions and
characterized chemogenomic and vaccine proteins from their operomes using a
combined bioinformatics approach. A precise function of 257 hypothetical proteins was
assigned based on their sequence-structure-function relationships, as evidenced by the
literature. We identified 12 virulence genes and 18 vaccinogenic proteins as reliable
antigenic determinants. The predicted virulence proteins were found to promote the
survival of this organism in the intestine of ruminant animals. The toll-like receptor,
nudix hydrolase, pseudo murein-binding repeat protein, and phosphonoacetate
hydrolase identified in this organism have shown more immunogenic and vaccinogenic
characteristics. Therefore, the new virulence factors and vaccine candidates identified
in this study would provide a quest for new anti-methanogenic drugs to mitigate the
methane emitted in ruminant animals.
ANALISA RESIDU PESTISIDA PADA UMBI BAWANG MERAH DI KABUPATEN PROBOLINGGO
Authors: Syamsulhadi Mochammad , Sunarto Bintar Probo , Taufiqurrahman Achmad Fitriadi
Published: September 2023

Bawang merah merupakan tanaman yang memiliki resiko tinggi dalam aktivitas budidaya pertanian, salah satunya adalah serangan OPT. Oleh sebab itu penggunaan pestisida menjadi tinggi. Tujuan penelitian ini adalah untuk mengetahui tingkat residu pestisida berbahan aktif Abamectin dan Mancozeb pada tanaman bawang merah di Kabupaten Probolinggo. Penelitian dilakukan di lahan pertanian bawang merah meliputi Desa Mranggon Lawang, Desa Sumberbulu, dan Desa Sumberkerang. Analisa residu dilakukan di Laboratorium Penyakit Tumbuhan, Departemen Hama dan Penyakit Tumbuhan, Fakultas Pertanian, Universitas Brawijaya. Waktu pelaksanaan pada bulan Mei sampai bulan Oktober 2021. Analisis residu pestisida dikerjakan menggunakan Gas Chromatography (Model 8000 TOP yang dilengkapi dengan Electron Capture Detector). Hasil penelitian menunjukkan semua sampel bawang merah meninggalkan residu pestisida. Namun residu pestisida masih berada di bawah ambang batas maksimal berdasarkan Standar Nasional Indonesia. Desa Mranggon Lawang yang menjadi desa sentra bawang merah terbesar di Kabupaten Probolinggo memiliki tingkat residu tertinggi dibandingkan dengan 2 desa lainnya. Hasil uji bahan aktif Abamectin pada daun sebesar 0,002; umbi 0,004; dan tanah 0,004 mg/kg. Sedangkan pada bahan aktif mancozeb pada daun 0,132; umbi 0,093; dan tanah 0,155 mg/kg. Hal tersebut menunjukkan bahwa perilaku petani bawang merah di Kabupaten Probolinggo terhadap penggunaan pestisida masih termasuk dalam batas wajar.
Primary Pulmonary Leiomyosarcoma : an Extremely Rare, Difficult-to-Manage Case of Lung Cancer
Authors: Binharyanto Adlan Pratama Binharyanto , Ngakan Putu Parsama Putra  , Ungky Agus Setyawan  , Dini Rachma Erawati  , Hendy Setyo Yudhanto
Published: September 2023

Background: Primary Pulmonary Leiomyosarcoma (PPL) known as <0.5% of total lung cancer. Histopathological examinations are the pillars of PPL diagnosis as clinical manifestations and radiological features are usually not specific. Treatments of PPL include surgical resection, radiotherapy, and chemotherapy.

Case Illustration: A 51-year-old male, smoker, with a productive cough for 2 weeks, accompanied by chest pain, weight loss, and loss of appetite. Imaging studies showed a solid mass in the right lung, which was confirmed through bronchoscopy, cytology, histology, and immunohistochemistry evaluations. Bronchoscopy showed an intraluminal mass in the right main bronchus suggesting malignancy. Immunohistochemistry of Desmin and Smooth Muscle Actin, which were positive, confirmed the diagnosis of PPL of the right lung stage T4N1M1a IVA.

Discussion: Surgical resection is the gold standard treatment for PPL whose clinical conditions and tumor spread still allowed for safe operation. Surgical resection did not undergo because already in stage IVA. Radiotherapy and chemotherapy can be added for patients who are unable to have surgery. There are no guidelines regarding chemotherapeutic regimens that are recommended for PPL. Cisplatin/carboplatin and etoposide are two chemotherapeutic agents that are commonly used in other variants of lung cancer. Cisplatin is successful in 5-23% of patients and etoposide is successful in 8%. Doxorubicin and ifosfamide are usually used for soft tissue sarcoma too. After administration of 4 cycles of carboplatin/etoposide, a chest CT scan with contrast recist shows the progression of PPL.

Conclusion: Carboplatin and etoposide have been long used as therapy for lung cancer. Currently, available literature shows that their effectiveness in PPL is still considered low. Nevertheless, more studies are needed to further explore the possibilities of using carboplatin and etoposide in PPL patients.

 

Keywords: chemotherapy, lung cancer, primary pulmonary leiomyosarcoma
A Comparative Assessment of Alternative Dispute Resolution for Financial Consumer Protection in Malaysia and Indonesia
Authors: Ilias Ibtisam a.k.a Ilyana , Mohd Zain Muhamad Ikhwan , Rahmat Nur Ezan , Keumala Dinda
Published: September 2023

The Ombudsman for Financial Services (OFS) handles financial services complaints in Malaysia. Meanwhile, the Alternative Institution for Dispute Resolution in the Financial Services Sector (LAPS SJK) handles financial disputes and safeguards customers from financial fraud in Indonesia. This study aims to analyse and compare the legal framework in both institutions for protecting financial consumers, considering their similarities and differences in regulatory approaches, consumer rights, and enforcement mechanisms. The findings of this study can provide insights for policymakers and regulators in both countries to enhance their efforts to safeguard the interests of financial consumers.
Understanding Urban Ornamentation Policy and Practice: Case study of Alor Gajah Melaka roadside sculptures
Authors: Harun Azahar , Abu Hassan Sharmiza , Mohd Abd Ghani Khairunnisa , Pattanachotti Ohm
Published: September 2023

This study investigates the significance of Roadside Sculptures in the context of urban ornamentation policy and practice, utilizing a triangulation method of observation, formal analysis, and expert rating.  Based on the findings the 14 Roadside Sculptures along the Alor Gajah-Melaka-Jasin highway feature four similar designs that promote environmental sustainability but lack cultural identity. Expert ratings, however, draw attention to problems in terms of functionality, idealization, shape, accessibility, sensibility, and exactitude. To improve the town's image, the study recommends that the Alor Gajah Municipal Council strengthen its urban ornamentation policy and practice by collaborating with the creative society and local community.
Islamic Views on the Objectives of Social Media Usage: A systematic literature review
Authors: Aiman Noh Natasya , Lokman Md Azzaat Ahsanie , Suyurno S. Salahudin , Ayub Mohamad Shafiei
Published: September 2023

Nowadays, the usage of social media is inevitable. While its expansion is welcomed, its adverse effects are also threatening. One of the areas that needs to be researched to combat those adverse effects is to see the role of objective-driven usage of social media, as many Islamic scholars believe that objective-driven action can lead to a better understanding of something and promote its proper conduct. This study aims to seek hikmah in using social media from an Islamic perspective, as has been studied by other researchers. Hikmah meant here is a deep understanding of the objectives to be achieved in conducting an action according to Islamic teachings. 22 research papers were reviewed from Web of Science, Scopus, ERIC, and Google Scholar from 2012 to 2022. The study found six main objectives of using social media from an Islamic perspective, namely to propagate Islamic teachings (da’wah), to build and sustain relationships (ukhuwwah), to educate to establish one’s character; to entertain well as to enjoin good and forbid harm.
A clinical case of an ischemic heart disease with Werner Syndrome
Authors: Khripun A. V. , Bagaeva I. A. , Godunko E. S. , Bukhtin O. V. , Terentyev A. A. , Chesnikova A. I.
Published: September 2023

Werner's syndrome is a disease characterized by premature aging, including the earlier development of diseases of the cardiovascular system: generalized atherosclerosis, hypertension, ischemic heart disease, and the occurrence of fatal complications such as myocardial infarction, stroke, at a younger age. It is cardiovascular diseases are the main cause of death of patients with Werner syndrome, whose life expectancy does not exceed 50 years. Therefore, patients with this syndrome need regular monitoring for early detection of signs of cardiovascular diseases, an increase in the quality and duration of life.
Factors of motivation of students and residents to study therapy and the possibility of their use in organizing the educational process
Authors: Ponomareva E. Yu. , Bogdalova L. R. , Rebrov A. P.
Published: September 2023

Objective: to study various aspects of motivation for learning among senior students, residents and postgraduates of a medical university.

Materials and methods: a survey of 174 students at the department was conducted (150 students of the 5th and 6th courses, 24 residents and graduate students). An electronic survey form was used. The survey was conducted simultaneously and anonymously.

Results: the results of the survey made it possible to discuss the motives and factors that determined the choice of a future profession, to establish changes in ideas about the profession during training, the advantages and disadvantages of the educational process, the organization and quality of independent work, the role of teachers and assessments, the opportunities provided for self-realization and their use in the educational process.

Conclusion: the study of student motivation factors in the process of studying a clinical discipline is a necessary process for their awareness by the teaching staff of the department and the implementation of "feedback" — use in the educational process.
Review of pharmacoeconomic studies of melanoma treatment for the period 2018–2023
Authors: Kokushkin K. A. , Zhuravleva M. V. , Byakhov M. Y. , Luchinin E. A. , Luchinina E. V.
Published: September 2023

When analyzing pharmacoeconomic studies of the skin melanoma treatment conducted in various countries, the combinations of vemurafenib + cobimetinib and encorafenib + binimetinib are the most acceptable therapy options in terms of increasing life expectancy with adjustments for quality, but, according to the clinical guidelines of the National Joint Oncology Network (NCCN), USA, version 2.2023 – “Melanoma: Cutaneous”, not for adjuvant therapy. At the same time, social networks can be a valuable asset of information about patient’s quality of the life. For the patients with advanced melanoma with a BRAF mutation, the combination of atezolizumab + vemurafenib + cobimetinib indicated the highest clinical effectiveness and can be recommended for pharmacotherapy under condition of drug price reduction.Comparison various drugs combinations with monotherapy for patients with unresectable or metastatic melanoma with a positive BRAF V600 mutation indicated that nivolumab + ipilimumab therapy is not cost-effective in comparison with nivolumab monotherapy, but combination of dabrafenib + trametinib, on the contrary, increases the patient's life expectancy compared to vemurafenib and it’s more cost-effective. It was shown that Pembrolizumab to increase life expectancy but it’s associated with increased costs compared to ipilimumab when comparing different monotherapy options. The assumed additional cost-effectiveness factor is acceptable for most European countries, because it does not exceed the “willingness to pay” threshold. It is necessary to conduct large-scale pharma-economic studies in order to identify the most cost-effective treatment for Russia for various variants of the course of melanoma, both of various combined regimens with each other, and their comparison with monotherapy. It is important to take into account also the costs of correcting undesirable adverse drug reactions, since they have a significant impact to the structure of direct costs. The development of innovative drugs for the treatment of melanoma is proceeding rapidly, however, access to these drugs is limited due to their high cost. Patient-centred drug development and reimbursement options need to be found.
Pathomorphological features of complications inpatients with bicuspid aortic valve
Authors: Pugina M. Y. , Gareev D. A. , Korzhova M. A. , Antonova I. V. , Shadrina U. M. , Babakekhyan M. V. , Voronkina I. V. , Uspensky V. E. , Gordeev M. L. , Mitrofanova L. B. , Irtyuga O. B.
Published: September 2023

Purpose: to evaluate the features of the course of complications in patients with BAV based on the results of a pathomorphological study.

Material and methods: a retrospective analysis of a register of 328 patients with AS and dilation of the ascending aorta (DAA), based on histological studies performed in 2010–2022 was carried out. 209 patients were diagnosed with BAV as a result of histological examination, and 119 patients were diagnosed with tricuspid aortic valve (TAV). The type of BAV was analyzed in 139 operated patients based on the results of the analysis of surgical protocols.

Results: according to the obtained results, the first type with fusion of the right and left coronary cusps prevailed among patients with BAV (78%), the smallest number of patients with BAV was with fusion of the right coronary and non-coronary cusps of the aortic valve (4%), while fusion of the left coronary with the non-coronary cusps of the aortic valve (AV) and patients with "true" BAV occurred in each case in 9% of patients. The formation of AS (75.6%), DAA (68.4%), and the combination of AS+DAA (81%) was more observed in the group of patients with the first type of BAV. According to the results of histology of the AV, there were no significant differences depending on the morphology of the valve. In particular, according to the results of AV histology, the frequency of calcification did not differ in groups of patients with BAV and TAV. Fibrosis with erasing of the layered histoarchitectonics of the AV of varying severity was detected in every second patient, regardless of the presence of congenital heart disease (CHD). According to the results of aortic histology, hemodynamic aneurysm in patients with BAV was much more common than in patients with TAV (p=0.0027). In addition, it was verified that in 39 patients out of 40 without pathomorphological changes in the aortic wall, aortic stenosis appeared in the diagnosis, of which 80% of patients had CHD: BAV. It was verified that 39 out of 40 patients without pathomorphological changes in the aortic wall had aortic stenosis in the diagnosis. Moreover, in 80% of patients, the main cause of aortic dilatation was identified as BAV.

Conclusions: the results of this study demonstrated that in the vast majority of cases, aortic dilatation and aortic stenosis are formed during fusion of the right and left coronary cusps. The absence of morphological changes in the aortic wall in almost every third patient with DAA and BAV, confirms the genetic contribution to the formation of aortic dilatation in this category of patients and requires further study.
Changes in the activity of markers of pro/antioxidant systems of liver tissue of animals carrying melanoma B16 with the introduction of dimethyltin bis(3,5-di-tert-butyl-4-hydroxyphenylthiolate) (Me-3) at different stages of the development of the tumor process
Authors: Alkhusein-Kulyaginova M. S. , Dodokhova M. A. , Vlasova N. D. , Antonyan B. G. , Alasheva M. H. , Grechina D. A. , Vasiliev I. V. , Gulyan M. V. , Kotieva I. M.
Published: September 2023

Objective: to evaluate changes in the activity of markers of pro/antioxidant systems of liver tissue of animals carrying melanoma B16 with the introduction of dimethyltin bis (3,5-di-tert-butyl-4-hydroxyphenylthiolate) (Me-3) at different stages of the development of the tumor process.

Materials and methods: the study was conducted on mice of the C57Bl/6 line (females). 48 hours after the transplantation of tumor cells to female mice of the C57Bl/6 line, the studied compounds were administered intraperitoneally 1 time per day for 5 days according to the classical method used for screening compounds with a suspected antitumor effect. The tested compounds were administered at a total dose of 375 mg/kg. The animals were removed from the experiment on the 7th and 18th days after the transplantation of tumor cells.

Results:  with the introduction of Me-3, there was a decrease in malondialdehyde as the main indicator of the activity of lipid peroxidation at all stages of the development of the tumor process.

Conclusions: the multidirectional effect of Me-3 on the enzymatic activity of the antioxidant system on days 7 and 18 of the development of melanoma B16 suggests some selectivity of action depending on the initial pro/antioxidant status of the cell, as well as the expediency of studying this group of compounds as a substrate for nanozymes with pro/antioxidant activity.
Factores pronósticos que producen retardo de cicatrización en úlceras de pie en diabéticos : Un modelo de regresión de Cox
Authors: Rodriguez-Alonso Dante , Ibañez Reluz Miguel , Chian Garcia Ana
Published: September 2023

Identificar los factores pronósticos del retardo de cicatrización(RC) de úlceras de pie(UP) en pacientes diabéticos seguidos con un mínimo de 12 meses en una unidad de pie diabético.(2)Métodos:113 UP fueron evaluadas para identificar los factores pronósticos epidemiológicos y clínicos respecto al RC usando un diseño de cohortes retrospectiva usando un modelo de regresión de Cox.(3)Resultados: edad en 61.73±11.78 años,el género masculino en 64.6%,el tiempo de enfermedad de 10 a más en 91.7% ,la ausencia de comorbilidad en 56.3%,la presencia de antecedente de úlcera previa en 52.1% ,la presencia de neuropatía periférica en 87.5% y la ausencia enfermedad arterial periférica en 56.2%. Noventa seis UP fueron seguidas por un año,los restantes 17 UP fueron excluidos por falta de seguimiento,la frecuencia de retardo de cicatrización fue de 47.9%,el tiempo promedio de cicatrización de las úlceras diabéticas fueron 5.02±2.32 meses y las factores pronósticos predictivos significativos fueron el antecedente de UP previa(p=0.03),presencia de comorbilidad(p=0.001) y área ulcerosa de más 3 cm2(p=0.001 ).(4)Conclusión: Este estudio encontró que los tres factores mencionados fueron pronósticos de RC en las UP de pacientes diabéticos seguidas durante un año siendo la última de mayor magnitud.
Keywords: retardo,cicatrización,pronóstico, úlcera de pie diabético.
Assessing the performance of large language models in answering questions regarding breast cancer in Chinese context: a cross-sectional study (Preprint)
Authors: Piao Ying , Chen Hongtao , Wu Shihai , Li Xianming , Li Zihuang , Yang Dong
Published: September 2023

BACKGROUND

Large language models (LLMs) are deep learning models designed to comprehend and generate meaningful responses, which have gained public attention in recent years.

OBJECTIVE

Considering that Chinese is one of the most widely spoken languages worldwide, the purpose of this study is to evaluate and compare the performance of LLMs in answering questions regarding breast cancer in Chinese context.

METHODS

ChatGPT, Eenie Bot and ChatGLM were chosen to answer 55 questions related to breast cancer posed by two oncologists. Responses were scored as comprehensive, correct but inadequate, mixed with correct and incorrect data, completely incorrect, or unanswered. The accuracy and length among answers from different models were evaluated using statistical software.

RESULTS

ChatGPT answered 55 questions, with 37 (67.3%) comprehensive answers and 5 (9.1%) correct but inadequate answers. Eenie Bot answered 55 questions, with 31 (56.4%) comprehensive answers and 7 (12.7%) correct but inadequate answers. ChatGLM generated 55 answers, with 31 (56.4%) comprehensive answers and 5 (9.1%) correct but inadequate answers. The accuracy of the three LLMs did not exhibit statistically significant. The accuracy of the three models in answering questions regarding breast cancer treatment was the lowest, with an average of 44.4%.

CONCLUSIONS

In Chinese context, the capabilities of ChatGPT, Eenie Bot, and ChatGLM are similar in answering breast cancer-related questions at present. These three LLMs may have a role as adjunct informational tools for breast cancer patients in Chinese context, offering guidance for general inquiries. However, it is important to approach their responses to specialized questions with caution.

CLINICALTRIAL

This is not a clinical trial.
The Education of Home Herbal Utilization As Healthy Drink for Virus Antidote
Authors: Sari Fita , Hasanah Fathul Hidayatul , Noor Farida , Hesturini Rosa Juwita
Published: September 2023

The herbal drink in Indonesia has a fast development for its easy usage and minimum side effect. Some house plants have metabolite compounds with an important role as antiviral such as rosella (Hibiscus sabdariffa), Curcuma domestica Val, Zingiber officinale, Cymbopogon citratus, and Pandanus amaryllifolius R. The purpose of our community empowerment activities was to introduce the benefits of house plants for supporting health, particularly as an antiviral during a pandemic. The method of community empowerment activities was carried out by explaining the example of home plants, their bioactive compound content, and their health benefits. The community was also taught to make simple and practical healthy drinks. The results showed that the community became more aware of the benefits of roselle and turmeric so that they did not doubt making a healthy drink to be consumed regularly during the pandemic. The results showed that about 85% of the community understood the benefits, and 90% were able to make herbal drinks. The conclusions of these community empowerment activities were going well. The community understood the benefits of house plants as an antiviral during a pandemic and succeeded in making simple healthy drinks from house plants.
Head Lice Eradication Efforts in a Group Home Environment: Yayasan Griya Asih Orphanage – A Case Study
Authors: Puspadewi Natalia , Ardianto Christian , Anastasia Gisella
Published: September 2023

Children living in orphanages are generally vulnerable to close-contact transmission diseases, including head lice infestation. The clinical manifestation of head lice infestation was relatively mild, such as itchy scalp, and hence it is often overlooked as a community health issue. Education plays an essential role in preventing re-infection and eradicating head lice infestation. The treatment options include chemical treatment using pediculicides and physical management by shaving the head and manually removing the parasite. This community service activity aimed to eradicate head lice from Yayasan Griya Asih Orphanage. A series of three activities were conducted at Yayasan Griya Asih Orphanage in Central Jakarta. Each activity was done around one month apart to evaluate the effectiveness of treatment. Firstyear medical students were recruited to participate in these activities to familiarize them with real-world community health problems. Student volunteers helped applied pulse doses of Permethrin 1% shampoo and provided health education activity. Fiftyfive Yayasan Griya Asih Orphanage residents joined this activity from mid-October until December 2022. Residents were instructed not to share their personal items to prevent re-infection. Health education activities were done using one-to-many followed by a one-on-one format. In conclusion, head lice infestation screening is essential in crowded environments, and permethrin 1% pulsed dose followed by personalized health education activities and pest control effectively broke the disease transmission chain and eradicated the head lice infestation.
Dermatosis pada Ruminansia akibat Defisiensi Vitamin C: Ulasan Singkat
Authors: Yanuartono Yanuartono , Indarjulianto Soedarmanto , Nururrozi Alfarisa , Ramandani Dhasia , Purnamaningsih Hary
Published: September 2023

Vitamin C bersifat esensial untuk mamalia, termasuk manusia, primata, dan marmut, meskipun mamalia lain, seperti ruminansia, babi, kuda, anjing, dan kucing, dapat mensintesis vitamin C dari glukosa di hati. Ruminansia pada dasarnya bergantung pada sintesis endogen karena vitamin C asal pakan sebagian besar dirusak semuanya oleh mikroorganisme rumen. Dengan demikian, ruminansia lebih bergantung vitamin C endogen untuk mencukupi kebutuhan tubuhnya guna memenuhi persyaratan fisiologis dibandingkan dengan hewan lain. Meskipun demikian, ruminansia muda lebih rentan terhadap defisiensi vitamin C karena  biasanya hanya memperoleh diet dengan kandungan vitamin C yang rendah.  Produksi vitamin C endogen pada ruminansia muda dapat mencapai tingkat maksimal setelah umur 16 minggu. Konsentrasi vitamin C pada ruminansia muda yang rendah tersebut  berpotensi menimbulkan dermatosis pada ruminansia muda. Tulisan ini bertujuan untuk mengulas secara singkatnya defisiensi vitamin C yang terkait dengan dermatosis pada ruminansia.
Kejadian Penyakit Toxocariasis pada Pasien Anjing dan Kucing di Klinik Hewan Jogja Periode 2019-2020
Authors: Prima Farhan Arhabi , Kamil Fa'iz Ihsanul , Tjahajati Ida , Widiastuti Tri Ari , Silalahi Gustaf Eifel
Published: September 2023

Latar Belakang: Toxocariasis merupakan penyakit infeksi yang sering menyerang pada hewan kesayangan anjing kucing disebabkan oleh cacing Toxocara sp. Penyakit ini termasuk dalam golongan penyakit zoonosis karena dapat menular pada hewan dan pada manusia dapat menyebabkan visceral larval migrans. Tujuan penelitian ini adalah untuk mengetahui angka kejadian penyakit zoonotik Toxocariasis pada pasien anjing dan kucing yang ditangani di Klinik Hewan Jogja selama masa pandemi Covid-19 tahun 2019-2020. Hasil penelitian diharapkan dapat memberikan gambaran angka kejadian penyakit zoonosis Toxocariasis pada anjing kucing, yang selanjutnya akan sangat bermanfaat untuk dasar edukasi ke masyarakat luas untuk pencegahan atau antisipasi penyakit zoonosis tersebut. Metode: Penelitian dilakukan dengan wawancara, dan melakukan pemeriksaan secara langsung pada pasien anjing kucing yang terindikasi menderita cacingan yang ditangani di KHJ selama covid-19 tahun 2019-2020. Selanjutnya dilakukan anamnesa, pemeriksaan fisik, pemeriksaan laboratorium feses, dan penanganan pasien. Apabila ditemukan telur cacing Toxocara sp pada pemeriksaan mikroskopis feses, maka pasien dinyatakan positif menderita Toxocariasis. Penelitian juga memanfaatkan data medical record yang ada di Klinik Hewan Jogja. Hasil data yang diperoleh, selanjutnya dicatat, disajikan dalam bentuk tabel, dan dianalisis secara diskriptif. Hasil: Berdasar pada hasil penelitian menunjukkan bahwa angka kejadian penyakit zoonosis Toxocariasis tahun 2019 dan 2020 adalah pada pada anjing 1,60% dan 1,58%, dan pada kucing 4,30% dan 6,66%.  Hasil penelitian menunjukkan bahwa selama covid-19 sepanjang tahun 2019-2020 Januari sampai Desember di Klinik Hewan Jogja selalu menangani pasien anjing dan kucing  yang menderita Toxocariasis.Simpulan Hasil penelitian memberikan gambaran bahwa kejadian penyakit zoonosis Toxocariasis selalu ada di masyarakat, sehingga edukasi ke masyarakat luas untuk pencegahan atau antisipasi penyakit zoonosis tersebut harus terus dilakukan, sehingga masyarakat sehat terbebas dari penyakit zoonosis Toxocariasis.
Pengaruh Penambahan Tepung Protein Maggot Black Soldier Fly (Hermetia illucens) terhadap Palatabilitas Pakan Kucing Komersial
Authors: Prasetyo Bayu Febram , Setiadi Dedi Rahmat , Agung Handri Dwi
Published: September 2023

Larva Black Soldier Fly (BSF) spesies Hermetia illucens mengandung nutrisi protein yang berpotensi menjadi sumber pakan alternatif hewan peliharaan yang ramah lingkungan, berkelanjutan, dan memiliki komposisi nutrisi yang ideal. Namun, laporan penggunaannya masih belum diketahui sebagai bahan pakan kucing. Uji palatabilitas pakan komersial dengan penambahan tepung protein maggot bertujuan untuk mengetahui daya terima pakan yang dikonsumsi. Uji palatabilitas dilakukan dengan metode monadik atau single bowl pada kucing domestik jantan dalam dua tahap, adaptasi pakan dan pemberian pakan uji pada empat kelompok perlakuan (0,25%, 50%, dan 75%) dengan penambahan tepung maggot, yang masing-masing terdiri dari 3 ekor kucing. Hasil pengujian diperoleh dari jumlah konsumsi pakan harian dengan cara jumlah pakan yang diberikan dikurangi dengan jumlah sisa pakan. Hasil penelitian menunjukkan bahwa tidak terdapat perbedaan yang nyata (P>0,05) pada perlakuan P1 119±15,36 (g/hari) dan 204±26,31 (kkal/hari) pada jumlah konsumsi pakan dan jumlah kebutuhan kucing harian. Dapat disimpulkan bahwa tepung protein maggot BSF dapat menjadi sumber bahan pakan kucing.
ARTIFICIAL INTELLIGENCE APPLICATION IN PHOTOACOUSTIC OF GASES
Authors: Lukić Mladena , Ćojbašić Žarko , Markushev Dragan D.
Published: September 2023

Photoacoustic spectroscopy is a powerful, non-destructive, ultrasensitive technique that covers a wide range of applications including atmospheric monitoring, industrial, environmental, and biomedical practice. In this paper, our attention is focused on the area of artificial intelligence implementation in photoacoustic spectroscopy of gases. Artificial intelligence has been proven as a very successful, effective, and promising method for the accurate and real-time determination of photoacoustic signal parameters, related to relaxation, thermal and other physical properties of various media (i.e., for solving the inverse photoacoustic problem). To improve the sensitivity and selectivity of the photoacoustic method feedforward multilayer perceptron network is applied for real-time simultaneous determination of photoacoustic signal parameters: vibrational-to-translational relaxation time, and radius of the laser beam. Also, to solve the problem of finding optimal values of these photoacoustic parameters, metaheuristic algorithms, genetic algorithms and simulated annealing are used. The performance of artificial intelligence methods has been tested on a set of experimental signals generated in the (SF6+Ar) gas. The potential advantages and disadvantages of those methods are discussed.
Does Corporate Governance Have An Effect On Financial Distress?: Altman Z-Score Approach
Authors: Puspitasari Fransiska Dwi Ratna , Irawan Dwi , Syam Dhaniel
Published: September 2023

Purpose: This study aims to test and obtain empirical evidence that projected Corporate Governance with managerial ownership, independent commissioners, board of directors, and audit committees affects financial distress. Methodology/approach: The object of this study is all mining sector companies listed on the Indonesia Stock Exchange in 2019-2021. The sample determination technique in this study used the Purposive Sampling method with a total sample of 35 companies. The data analysis technique in this study used the panel data regression testing method with the STATA statistical tool version 15. Findings: The results of the study partially showed that independent commissioners negatively affect financial distress in mining companies. Then for the variables of managerial ownership, board of directors and audit committees have no effect on financial distress. The results of the study simultaneously showed that together the variables of managerial ownership, independent commissioners, board of directors and audit committees had a significant effect on financial distress. Practical implications: These research findings have an impact on stakeholders and policy makers considering business continuity. Originality/value: This research has the latest in the form of modifications to models and objects that are relevant to the Financial Distress.
Mothers’ difficulties and hopes for early childhood English education
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, CUI CHUNLING
Published: September 2023

Objectives The purposes of this study is to explore the difficulties and hopes for English education of mothers who have children aged 3-5 years.
Methods To this end, from October 2022 to December 2022, in-depth interviews were conducted twice each with eight mothers who had experience in English education for their children. The collected data analyzed using qualitative research methods such as the data analysis spiral(Creswell, 2013) and open coding(Kim, 2012).
Results As a result of this study, mothers’ difficulties in English education for their children were limitations of English education at home, absence of qualified English education institutions, and the burden of education expenses. For the hopes in English education for their children were high-quality in English education at early childhood institutions, expanding opportunities for interaction with English native speakers, and the implementation of English education considering the interests of young children.
Conclusions This study is meaningful as it investigates the difficulties and hopes of mothers with young children regarding English education. It aims to provide foundational data for developing effective approaches to early childhood English education, considering the characteristics of young children.
The mediating effect of psychological independence in the relationship between the character strengths and career preparation behavior of college students
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Park Jeong-Yeon , Lee Jung-Hee
Published: September 2023

Objectives In this study, the mediating effect of psychological independence was analyzed in the relationship between university students' personality strengths and career preparation.
Methods This study conducted a survey of college students in Busan using the personality strength scale, career preparation behavior scale, and psychological independence scale. A total of 450 questionnaires were distributed, and 416 of the 430 collected were used as analysis data. Descriptive statistical analysis, t verification, F verification, correlation analysis, and regression analysis were performed on the collected data using the SPSS 26.0 program.
Results It was found that college students' personality strengths, career preparation behavior, and psychological independence differed according to their affiliates, gender, and credits. In addition, there is a significant positive correlation between personality strength, career preparation behavior, and psychological independence, and psychological independence partially mediates and affects the relationship between personality strength and career preparation behavior.
Conclusions The results of this study show that psychological independence plays an important mediating role in the relationship between personality strengths and career preparation behavior in career exploration and preparation activities of college students. Therefore, comprehensive counseling and educational programs should be supported through inter-institutional linkage so that college students can develop internal factors such as personality strengths and psychological independence in college life.
A systematic literature review on secondary quantum physics education
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Lee Taegyoung , Yoon Hyunju
Published: September 2023

Objectives This study aims to compare research trends domestically and internationally, hence deriving implications to the domestic research on the secondary quantum physics education in the future.
Methods We conducted a systematic analysis of quantum physics education literature published in major domestic and international journals related to physics education over the past 10 years.
Results By analyzing trends in quantum physics education research, we found that both domestic and international research were actively done in the last five years. Afterward, we identified research trends in specific themes: topics distribution, major research contents, and target learners. First of all, In terms of research topics, international literature mainly focused on the development of teaching and learning materials, while the domestic literature focused on students' learning. Regarding the contents of the research, ‘introduction to the quantum physics’ was the mostly covered one in both domestic and international studies, yet other contents, such as ‘probabilistic characteristics’, ‘interaction of light and matter(Duality and/or Complementarity)’, etc., ranked differently in two contexts. Lastly, our findings highlight that quantum physics education research primarily targeted high school students rather than middle school students. Notably, some studies on quantum education for teachers and pre-service teachers were reported only in the domestic context, which focused the importance of teachers' professional development.
Conclusions This study provides valuable insights into research trends in quantum physics education and offers implications for future research. The findings serve as an academic guide to explore the future direction of quantum physics education research.
The Effect on mathematical Creativity and Disposition learning to create problems using real-life learning materials
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, An Jong Su
Published: September 2023

Objectives The purpose of this study was to investigate how it affects students' mathematical creativity and disposition development after conducting problem-making class activities using various types of real-life activities.
Methods The study was conducted on 58 students in two classes in the second year of OO high school. OO High School is located in OO Metropolitan City. Two classes were selected based on the results of the midterm exam in the first semester of the second grade, and one class was divided into a research group and the other class was divided into a comparative group, and 13 classes were conducted for about two months from April 30 to June 27, 2022. The research group (29 students) taught problem-making classes using real-life activity sites, and the comparison group (29 students) taught traditional textbook-oriented classes.
Results As a result of this study, the effect of problem-making classes using real-life activity sheets on students' mathematical creativity and disposition areas was analyzed and obtained as follows. First, in this study, essential learning contents for each unit were set and problem-making class activities were conducted using real-life activity sheets. Thus, mathematical creativity and disposition could be enhanced. Second, as a problem-making class using real-life activities, it was more effective in mathematical creativity and disposition for students in the upper, middle, and lower ranks compared to traditional textbook-centered classes. Third, in the problem-making class using real-life activity sheets, the lower-ranked students who were not interested in the class were also interested and actively participated in the class, showing improvement in academic achievement.
Conclusions In conclusion, the problem-making class using real-life activity sheets was a teaching method that was helpful in the field of mathematical creativity and disposition.