bluuebunny/crossref_metadata_2025 huggingface dataset:
DVRSF: A Deep Reinforcement Learning Method Based on Dynamic Velocity Reward & Stagnation Fine
Authors: Zhang Qiyang , Chen Xiliang , Li Qingwei
Published: October 2022

When dealing with the difficult exploration problems caused by sparse rewards, pre-designed environment reward leads to poor performance of most RL algorithms. The existing algorithms fail to resolve the contradiction between the difficulty exploration and exploration efficiency. In this situation, it is necessary to design rewards more carefully, make more accurate judgments and feedback on the exploration status of agents. Therefore, we designed a RL exploration method based on trajectory entropy, and extracted two features during the training process to participate in the construction of internal rewards. On this basis, we add a monitoring method based on exploration speed to improve the over divergence problem in the agent exploration process. This method constructs a potential feature based on exploration speed according to the information sampling obtained in real time during training, gives real-time feedback to the agent, and dynamically adds it to the reward of each MDP. These two methods are called stagnation fine and velocity reward. Stagnation fine is intended to encourage the agent to get out of the dilemma as soon as possible when the agent is falling in. Velocity reward is used to improve the agent's exploration speed in the right direction and improve the over divergence of exploration. The algorithm has good generality, can avoid the influence of network structure in different algorithms, and can be easily added to existing RL algorithms, such as A3C and PPO. We evaluated our approach in different types of environments in Super Mario Bros. The experimental results show that the learning speed and accuracy of agents using DVRSF are significantly better than those of baseline such as PPO and A3C in most test tasks.
Three-Dimensional Hierarchical Porous Carbon with High Oxygen Content from Bitumite Mixed with Waste Powder Char for Excellent Wastewater Purification
Authors: Yin Yufeng , Zhao Yiting , Wang Jing
Published: October 2022

Waste powder char (WPC) is harmful to the environment and is abundant in the production process of the coal chemical industry, which will produce relatively low heat energy and release large amounts of coal ash if it is burned directly. To efficiently solve this issue and create high values, three-dimensional hierarchical porous carbons (HPCs) with abundant oxygen-containing groups were prepared by collaborative pyrolysis carbonization and steam activation from Yulin bitumite (YL) mixed with WPC. The effects of preparation parameters including WPC doping amount, activation temperature, and activation time on pore structure development and adsorption capacity of methylene blue from wastewater were explored in detail. The obtained HPCs are micropores structure combined with mesopores and the largest specific surface area (SSA) is reached to 1299.75 m2g− 1 (8-YLHPC-950-3). Furthermore, 8-YLHPC-900-3 presents a high oxygen content reaches 15.92wt%. And the SSA and total pore volume of HPC with an 8wt% WPC doping ratio are larger than that without WPC doping. Meanwhile, HPCs show the superior adsorption performance of methylene blue in aqueous solution, especially when the HPC was prepared at the activation temperature of 900 ℃, steam flow of 0.8 mLg− 1h− 1, and activation time of 3 h. It presents the optimal adsorption capacity that is 301 mgg− 1 of methylene blue adsorption value (MBV). We conclude a value-added utilization approach for coal based solid waste and a potential feedstock for adsorption material used in the purification of wastewater. The results achieved in this study provide a green and environmentally friendly method for the preparation of HPCs from waste powder char which is not only an industrial reference for the removal of methylene blue from wastewater by HPCs but also contributes to the sustainable development of the coal chemical industry.
Panitumumab plus trifluridine/tipiracil as anti-Epidermal Growth Factor Receptor rechallenge therapy in chemo-refractory RAS wild-type metastatic colorectal cancer: the randomized phase 2 VELO trial
Authors: Ciardiello Fortunato , Troiani Teresa , Napolitano Stefania , De Falco Vincenzo , Martini Giulia , Ciardiello Davide , Martinelli Erika , Corte Carminia Maria Della , Esposito Lucia , Famiglietti Vincenzo , Liello Alessandra Di , Avallone Antonio , Cardone Claudia , De Stefano Alfonso , Montesarchio Vincenzo , Zampino Maria Giulia , Bordonaro Roberto , Scartozzi Mario , Santini Daniele , Maio Massimo Di , De Vita Ferdinando , Altucci Lucia , Marrone Francesca
Published: October 2022

Current therapies for chemo-refractory metastatic colorectal cancer (mCRC) have limited efficacy. Rechallenge with epidermal growth factor receptor (EGFR) inhibitors in RAS wild-type (WT) mCRC could be valuable in this setting. In VELO, a randomized two-arm phase 2 trial, anti-EGFR monoclonal antibody panitumumab plus standard-of-care trifluridine/tipiracil (31 patients, arm B) was compared to trifluridine/tipiracil (31 patients, arm A) as third-line therapy (ClinicalTrials.gov Identifier NCT05468892). Primary endpoint, progression-free survival (PFS), was met. Median PFS was 4.0 months in arm B versus 2.5 months in arm A [hazard ratio (HR): 0.48; 95% CI 0.28–0.82; P = 0.007]. Baseline plasma RAS/BRAF WT circulating tumor DNA identified patients obtaining prolonged clinical benefit with panitumumab plus trifluridine/tipiracil as compared to trifluridine/tipiracil with PFS rates at 6 months of 38.5% versus 13% and at 12 months of 15.4% versus 0%, respectively. These findings warrant further development for liquid biopsy-guided anti-EGFR rechallenge combination strategies in chemo-refractory RAS WT mCRC.
Prevotella copri exhausts host’s intrinsic indol-3-pyruvid acid to promote breast cancer development: Inactivation of AMPK via UHRF1-mediated negative regulation
Authors: Su Jiyan , Lin Xiaojie , Li Dan , Yang Chunmin , Lv Shumei , Chen Xiaohong , Yang Xiujuan , Pan Botao , Xu Rui , Ren Liping , Zhang Yanfang , Xie Yizhen , Chen Qianjun , Xia Chenglai
Published: October 2022

The authors have requested that this preprint be removed from Research Square.
The effects and clinical outcomes of inflammation-related factors in the middle and upper calyceal renal calculi without ureteral stent after flexible ureterorenoscopy
Authors: Wang Shiping , Li Guikang , Wang Ruihan , Cui Yanxiu , Wang Pu , Yang Bin
Published: October 2022

Objective
To investigate the inflammatory factors and clinical outcomes of the middle and upper calyceal renal calculi after flexible ureterorenoscopy without the usage of the ureteral stent.
Data and Methods:
150 patients were randomly divided into three groups: Group A, Group B and Group C. In Group A, double-J stent was implanted preoperatively, but not postoperatively. In Group C, Double-J stent was implanted postoperatively, but not preoperatively. In Group B, double-J stent were implanted preoperatively and postoperatively. Finally, the inflammatory factors and clinical effects of the 3 groups were compared.
Results
There is a significant difference in operation time among the 3 groups with group A having the shortest time (P < 0.05). There have been no significant differences in stone clearance rate (P > 0.05). Additionally, it is observed that the incidence of postoperative hematuria and bladder irritation in group A has been comparatively lower than those in groups B and C (P < 0.01). At 24 hours after the operation among the 3 groups, and the incidence of fever between groups A and B observed has been considerably lower than that of group C (P < 0.05). Lastly, CRP and WBC in group A and B were lower than those in group C after operation(P < 0.05).
Conclusion
For the patients with middle and upper calyceal renal calculi, by prepositioning double-J stent before the operation along with the absence of ureteral stent after the flexible ureterorenoscopy, it has been presented that the operation time can be effectively reduced. At the same time, it will not affect the postoperative clearance rate, significantly reduce the incidence of postoperative complications, and will also not increase the postoperative-related inflammatory factors.
Histological study on the skin structure in two mudskippers, Periophthalmus waltoni and Boleophthalmus dussumieri in relation to their terrestrial life ​
Authors: Dorostghoal Mehran , Jazayeri Ashraf , Ashiri Sara
Published: October 2022

Microscopic structure of skin in two amphibious mudskipper fish; Boleophthalmus dussumieri Valenciennes, 1837 (B. dussumeri) and Periophthalmus waltoni Koumans, 1941 (P. waltoni) were investigated in relation to their lifestyle. The general structure of skin is the same among the two species. Epidermis in B. dussumeri was thicker significantly than P. waltoni. The dermal bulges were only well developed in the skin of B. dussumeri. Mucous cells were absent in the epidermis of P. waltoni but present in B. dussumeri. Both B. dussumeri and P. waltoni have well-developed swollen middle cells as a shared epidermal feature. The thickness of the middle cell layer of the epidermis in B. dussumeri was significantly greater than in P. waltoni. Capillaries in the dorsal and ventral parts of the body are more closely distributed to the epidermal surface in P. waltoni than in B. dussumeri. The diffusion distance in the dorsal epidermis of P. waltoni was less than that in the ventral epidermis of B. dussumeri. A comparative examination of the skin of mudskipper species suggests that, due to the more terrestrial lifestyle adopted by P. waltoni, the skin contributes more to respiration.
Thermodynamic Properties and Persistent Currents of Harmonic Oscillator Under AB-Flux Field in Point-like Defect with Inverse Square Potential
Authors: Ahmed Faizuddin
Published: October 2022

In this analysis, we study the eigenvalue solution of non-relativistic particles confined by the Aharonov-Bohm (AB) flux field with pseudoharmonic potential (harmonic oscillator plus inverse square potential) in a point-like global monopole defect. We then study the thermodynamic properties of harmonic oscillator, such as the vibrational free energy, mean energy, entropy, and specific heat capacity using the partition function Z(β) and analyze the influences of the topological defects and the magnetic flux field with this potential. Finally, an expression of persistent currents is obtained and analyze the effects of the topological defects and the potential.
Onion Yield and Internal Quality Increased by Straw Mulch and Reduced by Artificial Heat, but Not Affected by Kaolin Particle Film
Authors: Shock Clinton C. , Feibert Erik B. G. , Rivera Alicia , Wieland Kyle D.
Published: October 2022

Onion (Allium cepa L.) bulbs produced in the Pacific Northwest of the United States in 2014 and 2015 had unusually high incidence of internal decay. This decay was not detectable externally, leading to marketing problems when bulbs were packed and shipped to markets. The onion growing seasons in 2014 and 2015 were unusually hot, suggesting a connection of heat stress to bulb internal decay. Field studies to investigate the effect of temperature on onion bulb internal decay and yield were conducted in 2016–18 with drip-irrigated onions at the Oregon State University, Malheur Experiment Station located in eastern Oregon. Two long-day onion cultivars were submitted to four cultural practice variations to affect soil and bulb temperatures: bare soil check, supplemental heat using electric heat cables, white kaolinite clay application to the bulb sides and soil surface, and wheat (Triticum aestivum L.) straw mulch. The treatments established significant midafternoon average bulb and soil surface temperature gradients in the following order of increasing temperature: straw mulch, kaolinite, check, and supplemental heat. Averaged over years and cultivars, straw-mulched onions had the highest yield of bulbs larger than 102 mm diameter. Averaged over years and cultivars, onions receiving supplemental heat had the lowest total and marketable yield with no difference among the other treatments. Straw mulched onions had higher total and marketable yield than the bare soil check treatment in 2017, the hottest year. Averaged over the 3 years and two cultivars, marketable yield and yield of bulbs larger than 102 mm diameter decreased with increasing midafternoon bulb temperatures. Kaolinite application did not increase bulb yield nor bulb size compared with the bare soil check. The incidence of internal bulb decay was low all 3 years. In 2017, onions receiving supplemental heat had the highest internal decay and the straw-mulched onions had among the lowest internal decay. There was little difference in the measured soil moisture among treatments. Straw mulching may attenuate the negative effects of excessive heat on yield and bulb internal quality for long day onion production.
O Projeto África na UNILAB - ANU como catalisador de mudanças no currículo e na prática educativa
Authors: CUNHA Ana Cássia , MACEDO Rodrigo Peixto , QUADÊ Wilma João Nancassa , SILVA Gisleane Lima , CARVALHO Maria da Luz Fonseca de , RAMOS Jeannette Filomeno Pouchain
Published: October 2022

O presente trabalho é fruto da pesquisa concluída: “Descolonização dos currículos e das mentes na escola e na universidade: as contribuições do Projeto África na UNILAB - ANU no Maciço de Baturité - Ceará (2018-2019)”. Este artigo tem como objetivo apresentar o projeto de extensão universitária para a descolonização dos currículos e das mentes, para a prática educativa, bem como na formação dos bolsistas do PETHL da UNILAB. O estudo foi de natureza qualitativa, de cunho bibliográfico e documental, utilizando como instrumento de coleta de dados um questionário aplicado a 10 (dez) bolsistas, que participaram das ações. Fez-se necessário revisitar referencial teórico abordando a descolonização das mentes, com base nos saberes de Amílcar Cabral e Paulo Freire. Concluímos que o projeto vem desmistificando estereótipos em torno da África, tem promovido a reeducação numa perspectiva decolonial, como ponte para outras formas de saber, de ser, de viver, de conviver e aprender.
KNOWLEDGE, ATTITUDE, AND PRACTICE IN MANAGEMENT OF PATIENTS WITH MENTAL HEALTH DISORDERS IN EMERGENCY DEPARTMENTS IN MAKKAH REGION OF SAUDI ARABIA
Authors:   Assistant Professor At Taif University, Emergency Medicine Consultant., H. Al-Nofaiey Yasser , J. Al- Amri Lma ,   Assistant Professor At Taif University, Emergency Medicine Consultant., S. Al-Ghamdi Bushra ,   Assistant Professor At Taif University, Emergency Medicine Consultant., N. Al-Otaibi Ghadi ,   Assistant Professor At Taif University, Emergency Medicine Consultant., M. Al-Ghamdi Dalal ,   Assistant Professor At Taif University, Emergency Medicine Consultant., F. Khan Sohuar ,   Assistant Professor At Taif University, Emergency Medicine Consultant.
Published: October 2022

Background:Medical and psychiatric emergencies both have the potential to be life-threatening. Due to insufficient training or an unintelligible referral policy routine, many emergency physicians believe mental health illnesses to be a significant burden in health care Aim:This study aimed to analyze emergency physicians Knowledge, attitudes, and behaviors toward dealing with patients with mental health illnesses in the Makkah region of Saudi Arabia. Methods:a cross-sectional study was conducted on 152 emergency physicians in the Makkah region of Saudi Arabias hospitals. Data was collected from emergency physicians via an online questionnaire sent through social media platforms and self-administration surveys via data collectors. Results::74% of 152 emergency physicians have seen a mentally ill patient needing treatment. Only 50% of participants utilized tools to diagnose individuals with mental health illnesses, while their personal experiences influenced 54%. 65% of emergency physicians have seen that families may not graciously accept advice for a psychiatric referral, implying that there may be a stigma associated with mental health illnesses, which may impair patient management. Conclusion:The majority have had previous experience and exposure and believe they have an essential role in diagnosing mental health disorders (MHD). However, other results show that participants lack professionalism as they are influenced by their personal experiences when treating MHD. Participants were concerned regarding the lack of time and training that affected the management provided in ER. Efforts to improve the movement in residency periods, as well as the referral policy, are advised.
Creation of the initial breeding material of soft winter wheat with a complex of economically valuable traits
Authors: Murashko L. A. , Mukha T. I. , Humenyuk O. V. , Suddenko Yu. M. , Novytska N. V. , Martynov O. M.
Published: October 2022

Purpose. Creation of new breeding material of soft winter wheat, highly resistant to diseases of the ear and pest colonization for use in the breeding process.
Methods. The studies were carried out in 2017–2020 under conditions of artificial inoculation of wheat plants with pathogens of common bunt and fusariosis of the ear in field infectious nurseries of the Department of Plant Protection of the V. M. Remeslo Institute of Wheat of NAAS. An artificial infectious background of common bunt was created according to the method of A. I. Borggard-Anpilogov, which consists in contamination of seed material with spores several days before sowing. An artificial infectious background of fusarium ear blight was created by spraying soft winter wheat plants in the flowering phase with a suspension of spores isolated from the local pathogen population.
Results. According to the results of the conducted research, highly resistant (up to 5% ear dama­ge) combinations of hybrids of the fourth generation of soft wheat were selected against the causative agent of fusarium: ‘Berehynia Myronivska’ / ‘Nobeoka bozu’ had a thrips population of 5.2 ind./ear, and cereal leaf beetle – 35,0 ind./m2 and ‘Horly­tsia myronivska’ / ‘C-Lokia’, the thrips population of which was 5.0 ind./ear, cereal leaf beetle – 2.0 ind./m2. On an artificial infectious background of fourth-generation hybrids, in terms of resistance to common bunt, the crossing combinations ‘Berehynia Myronivska’ / ‘Horianka’, ‘Lehenda Myronivska’ / ‘Nana’ were selected, which were affected by common bunt from 15 to 20%, and thrips population was 2.8–8.6 ind./ear, cereal leaf beetle – 5.0–6.0 ind./m2. The highest indicators of the length of the ear, the number of grains in the ear and the mass of grain from the ear were obtained in the combinations of ‘Oberih Myronivskyi’ / ‘Maris Templer’ and ‘Berehynia Myronivska’ / ‘Horianka’, which were created in accordance with the breeding programs of soft winter wheat for resistance against fusarium head blight and common bunt.
Conclusions. The constant lines of soft winter wheat, isolated by complex resistance against diseases and pests, are used in the breeding process of the V. M. Remeslo Institute of Wheat of NAAS and the National Center of Plant Genetic Resources of Ukraine (The Plant Production Institute named after V. Ya. Yuriev, Kharkiv).
Remote spectral analysis of varieties and lines of winter wheat during the flowering period
Authors: Topko R. I. , Kovalyshyna H. M.
Published: October 2022

Purpose. Conduct a spectral assessment of winter wheat varieties (‘MIP Assol’, ‘Balada Myronivska’, ‘Hratsiia Myronivska’, ‘MIP Yuvileina’, ‘MIP Lada’, ‘MIP Dniprianka’, and standard ‘Podolianka’) and perspective breeding lines (‘Erythrospermum 55023’, ‘Lutescens 22198’, ‘Lutescens 37519’, ‘Lutescens 60049’, ‘Lutescens 60107’) of Myronivka Institute breeding during the flowering period and to evaluate the dependence of the obtained NDVI indicator on their productivity.
Methods. The research was conducted during the 2018/19–2020/21 growing seasons in the breeding crop rotation of the winter wheat breeding laboratory of the V. M. Remeslo Myronivka Wheat Institute of the National Academy of Sciences of Ukraine. The main method of research is field, supplemented by analytical studies, measurements, calculations and observations. Obtaining values of vegetation indices of varieties and breeding lines of winter wheat was carried out using the Mavic zoom 2 UAV (unmanned aerial vehicle) using the Parrot Sequoia multispectral camera. Pix4Dcapture and Pix4Dmapper programs were used to create an orthophoto map. Photographing was carried out with a multispectral camera at a height of 30 m above the level of the object under study in order to improve the quality of the orthophoto map with an overlap of 80% of the images and a time interval of 2 seconds. The NDVI index (normalized difference vegetation index) was calculated according to the appropriate formula.
Results. According to the research results, regardless of the conditions of the year, in the first, optimal sowing period (25.09–05.10), the NDVI indicator in the flowering-ripening phase of wheat had higher values than in the second, late period (05–15.10) (average value over three years for the first semester was 0.69, the second – 0.62). In the course of the research, we established the dependence of the vegetation index NDVI on the level of productivity of wheat genotypes. The best varieties and promising lines among those studied were ‘MIP Lada’, ‘Lutescens 55198’ and ‘Lutescens 60049’, as well as ‘MIP Assol’ and ‘Hratsiia Myronivska’, which were less sensitive to sowing dates and had a higher index and control of yield indicators even with late sowing dates.
Conclusions. Although existing today phenotyping methods need to be improved and localized, in the near future they will become an indispensable tool for the breeder, which will increase the volume of studied varieties and improve the quality of the results of morpho-biological analysis
Flavonoids for the Treatment of Breast Cancer, Present Status and Future Prospective
Authors: Sahoo Sanjeeb Kumar , Sahoo Sonali , Mohapatra Priyanka
Published: October 2022

Breast Cancer is one of the most notorious cancer affecting women globally. Current therapies available for
breast cancer treatment have certain limited efficacy; develop drug resistance and severe adverse effects. Thus, identifying
novel therapies for treatment will reduce the devastating effect on cancer survivors. The exhilarating and fastgrowing
studies on flavonoids have evidenced that it has the potential to inflect various antitumor activity and modulate
various signal transduction pathways in carcinogenesis. Flavonoids also have been found to regulate cellular metabolism
and oxidative stress, cell cycle progression, angiogenesis and metastasis, ultimately preventing the progression
of the diseases. As per the reports, a flavonoid-rich diet appears to be the most potent and promising approach to
abate the risk of cancer. Thus, now a day, these are the prime target for drug discovery research. Based on existing
findings, it can be concluded that beyond the currently employed chemotherapeutics, natural products (like flavonoids)
exhibit pleiotropic, multi-target activities and are budding as possible complementary chemopreventive molecules
against breast cancer with fewer side effects than conventional therapy. In this review, we comprehensively highlight
an outline of the multiple pleiotropic pharmacological effects of various major classes of flavonoids on breast cancer
with their specific mechanisms underlying its anticancer effect.
An Efficient Power Management Strategy of a Solar Powered Smart
Camera-road Side Unit Integrated Platform
Authors: Ibrahim Qutaiba
Published: October 2022

Background:

This paper proposes efficient employment of a self-powered VANET infrastructure.
Miscellaneous techniques and algorithms are suggested to help the realization of such a
framework.

Objective:

The current work attempts to enhance the network architecture of the Green VANET by
adopting the self-powered fog computing concept for better networking, computing, and storage performance.

Method:

The green fog layer consists of three components: a self-powered edge server, Wireless Solar
Routers (WSRs), and a new device resulting from the integration between a solar-powered Smart
Camera (SC) and a solar-powered Road Side Unit (RSU) in order to create a better sensing mechanism
of the road traffic.

Result:

A proper power management strategy is suggested and installed locally in the self-powered
devices to decrease their power utilization by 80% and lengthen their batteries' lifetime from 17 to 64
hours.

Conclusion:

The different methods and algorithms suggested in this paper are realized and tested using
an experimental framework based on a mix of evaluation kits. It is noticed that the suggested
power management algorithm can adjust the duty cycling according to the accessible energy levels,
and thus, the SC-RSU nodes and the WSRs keep on working in a pre-managed and arranged manner.
Keragaan Beberapa Galur Jagung Ketan (Zea mays L. var. ceratina Kulesh) Pada Selfing Kedua (S2)
Authors: Cantika Devira , Sugiharto Arifin Noor
Published: October 2022

Jagung ketan memiliki kandungan amilopektin yang lebih tinggi daripada jagung lainnya. Permintaan jagung ketan untuk industri pakan terus meningkat. Peningkatan produksi jagung ketan dapat menggunakan varietas unggul. Pembentukan varietas unggul memerlukan galur yang memiliki karakter unggul sebagai tetua. Dalam penentuan tetua unggul dilakukan proses penilaian penampilan melalui keragaan sebagai identitas galur. Penelitian ini bertujuan untuk mengetahui keragaan karakter kualitatif dan kuantitatif, untuk menduga nilai heritabilitas arti luas dan koefisien keragaman genetik, dan untuk mendapatkan tetua potensial. Penelitian ini dilaksanakan di Dusun Areng-areng, Kelurahan Dadaprejo, Kecamatan Junrejo, Kota Batu, Jawa Timur pada September - Desember 2021. Bahan tanam yang digunakan berupa koleksi benih jagung ketan dari CV. Blue Akari yaitu galur S2 hasil persilangan (jagung ketan x jagung ungu manis). Penelitian ini menggunakan Rancangan Acak Kelompok (RAK) dengan 3 ulangan. Perlakuan yang digunakan yaitu galur sejumlah 13 perlakuan, setiap perlakuan terdapat 39 satuan percobaan. Variabel pengamatan tanaman yang diamati terbagi menjadi 2 yaitu, karakter kualitatif dan karakter kuantitatif. Analisis karakter kualitatif berdasarkan metode skoring masih terdapat keragaman. Analisis karakter kuantitatif berdasarkan Analisis ragam terdapat beberapa karakter kuantitatif yang berbeda nyata. Analisis KKG memiliki keragaman yang tergolong rendah berkisar antara 0,48 – 10,88%, sedangkan nilai KKF tergolong rendah hingga agak rendah berkisar antara 0,53 – 35,33%. Pendugaan heritabilitas tergolong rendah hingga tinggi berkisar antara 0,058 – 97,79%. Galur yang berpotensi untuk dijadikan tetua unggul yaitu JP-D3, JP-D7, JP-D8, JP-D10, JP-D11, dan JP-D13 karena memiliki keunggulan dan keseragaman pada karakter kualitatif dan karakter kuantitatif.
Short Hydroacylation-Based Synthesis of Four Aryl-3-hydroxypropanones, Predictable Biomass-Derived C9 Platform Molecules
Authors: Bassoli Simona , Schallmey Anett , Oble Julie , Poli Giovanni , Pradal Alexandre
Published: October 2022

A two-step protocol for the synthesis of aryl-3-hydroxypropanones, which were regarded as lignin degradation products, was proposed herein. This protocol provided a more rapid and easier access to aryl-3-hydroxypropanones, and aryl-3-hydroxypropanones were expected to be ideal platform molecules for the synthesis of more complex value-added targets.
Dynamic Resting-State Functional Connectivity in Migraineurs
Authors: IMAI NOBORU
Published: October 2022

Functional magnetic resonance imaging (fMRI) is widely used to detect changes in the resting-state brain networks of migraine patients. Functional connectivity fMRI analysis examines the functional organization of the brain based on temporal correlations of blood oxygen level-dependent signal changes in different brain regions. Most previous resting-state fMRI studies have assumed that functional connectivity between brain regions remains relatively stable over time. However, it is now known that the brain is a complex system that undergoes time-dependent dynamics. Therefore, functional connectivity may change over time. In recent years, resting-state fMRI analysis has evolved from the detection of static coupling to the study of dynamic connectivity. However, studies of dynamic functional connectivity in migraine patients are limited. Related studies have shown that dynamic functional connectivity analysis reveals significant changes in connectivity and abnormal networks not found in static functional connectivity analysis.
Mailed Letter Versus Phone Call to Increase Diabetic-Related Retinopathy Screening Engagement by Patients in a Team-Based Primary Care Practice: Prospective, Single-Masked, Randomized Trial
Authors: Stamenova Vess , Nguyen Megan , Onabajo Nike , Merritt Rebecca , Sutakovic Olivera , Mossman Kathryn , Wong Ivy , Ives-Baine Lori , Bhatia R Sacha , Brent Michael H , Bhattacharyya Onil
Published: October 2022

Background

Vision loss from diabetic-related retinopathy (DR) is preventable through regular screening.

Objective

The purpose of this study was to test different patient engagement approaches to expand a teleophthalmology program at a primary care clinic in the city of Toronto, Canada.

Methods

A teleophthalmology program was set up in a large, urban, academic, team-based primary care practice. Patients older than 18 years with type 1 or type 2 diabetes were randomized to one of the following 4 engagement strategies: phone call, mail, mail plus phone call, or usual care. Outreach was conducted by administrative staff within the clinic. The primary outcome was booking an appointment for DR screening.

Results

A total of 23 patients in the phone, 28 in the mail, 32 in the mail plus phone call, and 27 in the control (usual care) group were included in the analysis. After the intervention and after excluding patients who said they were screened, 88% (15/17) of patients in the phone, 11% (2/18) in the mail, and 100% (21/21) in the mail and phone group booked an appointment with the teleophthalmology program compared to 0% (0/12) in the control group. Phoning patients positively predicted patients booking a teleophthalmology appointment (P<.001), whereas mailing a letter had no effect.

Conclusions

Patient engagement to book DR screening via teleophthalmology in an urban, academic, team-based primary care practice using telephone calls was much more effective than patient engagement using letters or usual care. Practices that have access to a local DR screening program and have resources for such engagement strategies should consider using them as a means to improve their DR screening rates.

Trial Registration

ClinicalTrials.gov NCT03927859; https://clinicaltrials.gov/ct2/show/NCT03927859
Views, Use, and Experiences of Web-Based Access to Pediatric Electronic Health Records for Children, Adolescents, and Parents: Scoping Review
Authors: Hagström Josefin , Blease Charlotte , Haage Barbara , Scandurra Isabella , Hansson Scharlett , Hägglund Maria
Published: October 2022

Background

Ongoing efforts worldwide to provide patients with patient-accessible electronic health records (PAEHRs) have led to variability in adolescent and parental access across providers, regions, and countries. There is no compilation of evidence to guide policy decisions in matters such as access age and the extent of parent proxy access. In this paper, we outline our scoping review of different stakeholders’ (including but not limited to end users) views, use, and experiences pertaining to web-based access to electronic health records (EHRs) by children, adolescents, and parents.

Objective

The aim of this study was to identify, categorize, and summarize knowledge about different stakeholders’ (eg, children and adolescents, parents, health care professionals [HCPs], policy makers, and designers of patient portals or PAEHRs) views, use, and experiences of EHR access for children, adolescents, and parents.

Methods

A scoping review was conducted according to the Arksey and O’Malley framework. A literature search identified eligible papers that focused on EHR access for children, adolescents, and parents that were published between 2007 and 2021. A number of databases were used to search for literature (PubMed, CINAHL, and PsycINFO).

Results

The approach resulted in 4817 identified articles and 74 (1.54%) included articles. The papers were predominantly viewpoints based in the United States, and the number of studies on parents was larger than that on adolescents and HCPs combined. First, adolescents and parents without access anticipated low literacy and confidentiality issues; however, adolescents and parents who had accessed their records did not report such concerns. Second, the main issue for HCPs was maintaining adolescent confidentiality. This remained an issue after using PAEHRs for parents, HCPs, and other stakeholders but was not an experienced issue for adolescents. Third, the viewpoints of other stakeholders provided a number of suggestions to mitigate issues. Finally, education is needed for adolescents, parents, and HCPs.

Conclusions

There is limited research on pediatric PAEHRs, particularly outside the United States, and on adolescents’ experiences with web-based access to their records. These findings could inform the design and implementation of future regulations regarding access to PAEHRs. Further examination is warranted on the experiences of adolescents, parents, and HCPs to improve usability and utility, inform universal principles reducing the current arbitrariness in the child’s age for own and parental access to EHRs among providers worldwide, and ensure that portals are equipped to safely and appropriately manage a wide variety of patient circumstances.

International Registered Report Identifier (IRRID)

RR2-10.2196/36158
Artificial Intelligence in the Field of Cyber Security
Authors: K Ms. Jayabalaji , R Harini , S Vengadesh
Published: October 2022

Abstract: The cyber security industry's financial resources and human abilities to assess and battle every new type of cyber danger have been overwhelmed by the surge in cyber assaults. With the rise of the digital world, there is a rising quantity of personal and financial data that has to be secured against cyber-attacks. In reality, cyber assaults may devastate an organization's reputation or cause it to fail totally. This study investigates the use of artificial intelligence (AI) to improve cyber security. Artificial intelligence has advanced to the point that it has surpassed human capability in activities like data analytics. The analysis indicated that using AI to regulate cyber attacks has both benefits and drawbacks the benefits exceed the drawbacks. This study discovers that AI systems are likely to increase the safety of customers and enterprises in cyberspace due to the fast and efficient technology necessary to operate them[2] .
Psychological disorders and related factors among Chinese adolescent earthquake survivors during the COVID-19 pandemic
Authors: An Jing , Zhang Chong , An Jinlong , Cao Qilong , Huang Weidong , Wang Siwei
Published: October 2022

We studied the mental health of adolescent earthquake survivors during the COVID-19 pandemic by measuring their psychological disorders with the Zung Self-Rating Depression Scale (SDS) and their risk factors with the Zung SelfRating Anxiety Scale (SAS). We conducted an exploratory factor
analysis and logistic regression modeling and the results revealed that there were high levels of depression and anxiety among the 385 participants. Significant indicators of depression as measured by the SDS were family monthly income, years of education of the adolescents, and marital status
of parents. The SAS measured family monthly income as a significant factor predicting anxiety. This study will provide references for future psychological support and early interventions for disadvantaged groups during the ongoing COVID-19 pandemic.
Career plateauing and work engagement of university faculty members: The mediating role of organizational identification
Authors: Yuan Kai , Qin Yabing , Zhang Kuakua
Published: October 2022

Research on career plateau has rarely addressed university faculty. However, given the negative outcomes of such a plateau, it is important to explore its effects. Drawing on social identity theory, this study examined the mediating effect of organizational identification in the relationship
between career plateau and work engagement. Three-wave data were collected from a sample of 389 university faculty in China. The results indicate that hierarchical plateau and job-content plateau had negative effects on work engagement. Moreover, organizational identification was found to
mediate the relationship between jobcontent plateau and work engagement. The theoretical and practical implications of the results and directions for future research are discussed.
Understanding the role of mobile applications in brand loyalty in the coffee chains industry
Authors: Kim Byoungsoo , Kim Daekil
Published: October 2022

With the spread of COVID-19, the development and distribution of mobile apps is a significant issue for sustainable growth in service industries. This study identified the relationship between customer loyalty to mobile apps and brand loyalty, and investigated the role of perceived
benefits provided by mobile apps in enhancing brand loyalty. We integrated a set of perceived benefits into the expectation–confirmation model and collected data through a survey of 365 consumers in South Korea who used mobile apps of coffee chains. Results reveal that brand loyalty
was affected by consumer satisfaction with and loyalty to mobile apps. Entertainment and recognition both played a significant role in increasing loyalty to mobile apps, but the effects of monetary saving and exploration were nonsignificant. The study findings confirm the positive impact of
social benefits on consumer satisfaction with and loyalty to mobile apps.
Raffle marketing: Focusing on purchase orientation, conspicuous consumption, postpurchase satisfaction, and repurchase intention
Authors: Lee Inyup , Kim Dong-Kyu , Ha Jaehyun , Choi Chulhwan
Published: October 2022

As a marketing strategy to stimulate consumers' spending desires, limitededition products are now being sold through raffles. Using data obtained from 365 consumers who had previously purchased sports shoes, the results revealed differences between consumers who had participated in
raffles and those who had not in terms of their purchase experience, propensity toward conspicuous consumption, and intention to repurchase. Propensity toward both purchases made for entertainment and impulsive purchasing were statistically higher in the group who had participated in raffles.
Regarding conspicuous consumption propensity, the group who had participated in raffles showed a stronger tendency to buy famous brands, seek others' recognition, and pursue fashion trends. Although the difference in postpurchase intention between the two groups was not statistically significant,
those who had participated in raffles showed stronger repurchase intentions. The results indicate that the sales method for limited-edition products can affect the purchase propensity of consumers and their postpurchase behavior.
LAVRQN. NEW POLYMER COMPOSITION FOR THE RESTORATION OF TRIBOCOUPLINGS OF MACHINES
Authors:   Национальный исследовательский Мордовский государственный университет им. Н.П. Огарева, RADAYKINA ELENA A. , KOTIN ALEKSANDR
Published: October 2022

The use of antifriction wear-resistant self-lubricating polymer compositions are of great interest, which can be successfully used for the manufacture or restoration of a large range of tribocoupling of machines. (Research purpose) The research purpose is studying the properties of polyamide composites filled with molybdenum disulfide MoS2 and comparing the obtained values with pure polyamide 6. (Materials and methods) Compounding of components was carried out on a laboratory two-rotor mixer HAAKE PolyLabPheomix 600 OS with Roller rotors. The compounding temperature was 230 degrees Celsius, the rotation speed of the rotors was 50 revolutions per minute. Plates with a size of 200 by 200 by 1.1 millimeters were made on a hydraulic press to study the physical and mechanical properties of the resulting composite material, five samples (type 1) for each composition were cut out for physico-mechanical tests. Tests were carried out on a UAI-7000 M breaking machine at a temperature of 23 ± 2 degrees Celsius and a tensile velocity of 10 millimeters. (Results and discussion) The introduction of molybdenum disulfide leads to an increase in the strength parameters of the polymer composition. Samples with a filler content of less than 10 percent are capable of significant forced-elastic deformation, which suggests the possibility of orientational hardening of the composite. (Conclusions) Based on the conducted physical and mechanical tests, that the addition of molybdenum disulfide can significantly improve the elastic-strength properties of PA-6. At the same time, its content in the compound should not exceed five percent. The resulting polymer compositions can be successfully used for the manufacture of parts that form friction pairs both in the manufacture and repair of machines.
RATIONAL CONDITIONS FOR ULTRASONIC STABILIZATION OF RESIDUAL STRESSES IN ROUND PLATES
Authors:   Kazakhstan University of Innovation and Telecommunication Systems, BALTAEV TIMUR , OMAROV AKYLBEK , NURGALIEV LENUR ,   West Kazakhstan Innovation Technological University
Published: October 2022

In modern conditions of a market economy, the problem of improving the quality of products and ensuring their competitiveness for the countries of the Eurasian Economic Union is becoming the most urgent. The solution of existing problems is aimed at the development of processing methods based on the use of ultrasonic energy. The use of ultrasound makes it possible to increase the scientific and technical level of technological processes for processing parts from hard-to-process materials in mechanical engineering, and in some cases, to solve technological problems of their production in a fundamentally new way. (Research purpose) The research purpose is the optimization of the processing mode of round elastic plates, widely used in various automatic devices in order to stabilize residual stresses in their material. (Materials and methods) One of the most important requirements for such products is the exact match of the deformation value of the plate and the measured pressure of the medium. This is not always ensured due to the emerging phenomenon of elastic static hysteresis, as a result part of the energy spent on deformation of the plate is absorbed by the plate material and a so-called hysteresis loop is formed. This leads to a significant loss of accuracy of measuring instruments. (Results and discussion) The article presents the main stages of the process of choosing stabilization conditions: describing the tasks of ultrasonic vibromechanical processing; justification of the criterion for describing conditions; identification of statistical parameters characterizing the initial state of the part; mathematical modeling of the potential energy of residual stresses in the part; modeling the relaxation process of residual stresses in the part. (Conclusions) The theoretical foundations of a new microdynamic method allows correcting deviations of geometric shape, removing residual stresses and stabilizing the geometric parameters of round plates.
PYAIIC. PRODUCTION OF ABRASIVE MATERIALS FOR SURFACE PREPARATION FOR PLASMA SPRAYING
Authors:   Federal Scientific Agroengineering Center VIM, ZADOROZHNIY ROMAN , TRIFONOV GRIGORIY ,   Air Force Academy named after Professor N.E. Zhukovsky and Yu.A. Gagarin, ROMANOV IL'YA ,   Federal Scientific Agroengineering Center VIM, KRAVCHENKO IGOR' , KRASNOVA MARINA ,   Russian State Agrarian University - Moscow Timiryazev Agricultural Academy,   Voronezh State Technical University
Published: October 2022

Within the framework of the state import substitution program, the issues of developing and using low-cost, environmentally friendly, highly efficient, simple and universal technologies for producing abrasive materials with the predefined fractional composition are relevant. (Research purpose) The research purpose is investigating the process of producing an abrasive material of a predefined fractional composition for sandblasting of the part before its plasma spraying. (Materials and methods) An experimental installation with fluidization and gas flow stabilization devices used to separate multicomponent material into dimensional fractions was used to obtain coatings. (Results and discussion) The article presents the technological process of separation of quartz sand and an experimental installation for producing abrasive material of specified fractions. Using the described process, which includes equations for the separation of abrasive particles of quartz sand, increases the accuracy of obtaining the material of the necessary granulation for sandblasting the part before plasma spraying. (Conclusions) The ways of solving the problem of separation of multicomponent materials (quartz sand and possible impurities) were described for sandblasting the surfaces of parts before applying plasma spraying technology to specified size fractions, which directly improves the quality of the coating applied during further processing of the surfaces of parts. In the method described in this paper, the deviation of the particle size from the calculated value is no more than 2-3 percent, with other methods for obtaining a material with a given size fraction, the deviation of the particle size from the calculated value reaches 10 percent.
ERFWHG CHANGE IN THE PULSE-POWER CHARACTERISTICS OF THE ENGINE WORKING WITH THE CYLINDER DISCONNECTING IN IDLE MODE
Authors:   Novosibirsk State Agricultural University, KURNOSOV ANTON , GUSKOV YURIY , KORNIENKO VLADIMIR , GALYINSKY ANDREY
Published: October 2022

The parameters of gas-dynamic processes in the engine cylinders affect the forces on the supports. By evaluating the impulse actions and peak values of the forces on the supports, it is possible to evaluate the efficiency of each cylinder. (Research purpose) The research purpose is studying the process of changing the external impulse-power characteristics of an internal combustion engine operating in idle mode with some disconnected cylinders. (Materials and methods) The article presents a methodology for quantifying the impulse effect of the engine on the supports during the combustion cycle and expansion of each cylinder and experimental studies on a diesel four-cylinder four-stroke engine D-243. During the research, the fuel supply to one, two and three cylinders was gradually turned off and the forces arising in the supports were recorded using strain sensors and a set of measuring equipment. (Results and discussion) With uniform engine operation with a minimum crankshaft rotation speed in idle mode, the peak values of the forces on the supports during the combustion and expansion cycles reached an average value of 200 newtons, the magnitude of their impulse action takes an average value of 8.2 kilonewtons-seconds equal for all cylinders. With the gradual shutdown of the cylinders, the peak values of the forces on the supports at the combustion and expansion stroke increase to 910 newtons when working with only one cylinder, and the average value of the force pulse is 50 kilonewtons-seconds. The depressurization of non-working cylinders increases the peak force effect of the working engine cylinder on the supports to 1200 newtons, and the pulsed force effect up to 85 kilonewtons-seconds. (Conclusions) The proposed methodology for evaluating the parameters of the gas-dynamic processes of the engine based on the external pulse-power characteristics will allow to quickly assess the technical condition and efficiency of each cylinder and the engine as a whole.