bluuebunny/crossref_metadata_2025 huggingface dataset:
Optimasi Konsentrasi Sukrosa dan Propilen Glikol dalam Formulasi Chewable Gummy Tablet Ekstrak Daun Kelor (Moringa oleifera L)
Authors: Rani Karina Citra , Nikmatul Ikhrom Eka Jayani  , Maulidia Setaratika  , Syalza Mumpuni Kusuma Dewi
Published: June 2023

Latar Belakang: Moringa leaves extract is promising to develop into nutraceutical products, especially a chewable gummy. The desirable characteristics of chewable gummies are soft, elastic, springy, and flexible. Gelatin is a widely used gelling agent which has been proven to maintain gel structure during storage. The other ingredients which also determine the chewable gel structure are filler and plasticizer. The aim of this study was to determine the effect of sucrose and propylene glycol concentration on Moringa leaves extract based chewable gummy. Metode: The preparation of chewable gummy tablets was conducted by the pour method. Factorial design study (22) was applied in this study to analyze the effect of two factors herein filler and plasticizer. Two levels of concentration were optimized in each factor, herein sucrose (30% and 35% concentration) and propylene glycol (2% and 4% concentration) on the physical characteristics of the gummy tablet.  Hasil: The results of the factorial analysis showed that the increase in sucrose concentration will produce a longer dispersion time and lower swelling ratio. Meanwhile, the increase in propylene glycol decreases the syneresis potency. The alteration of physical characteristics was observed during 14 days of storage, particularly in dispersion time, swelling ratio, and syneresis percentage. Kesimpulan: Based on the results of feasible design space, sucrose concentration (30-35%) and propylene glycol concentration (2-4%) optimized in this study produce the desirable characteristics of chewable gummy.
Biological Education in Indonesian Senior High School: Study in Textbook and Curriculum Policy
Authors: Hastangka Hastangka  , Latifa Nuraini
Published: June 2023

Background: Biology education has a vital role in scientific development, strengthening the position of biology education for sustainable development and advancing biological science. During this time, biology materials developed rapidly. Methods: Writing the word Abstract using Cambria 9pt, in italics. The Abstract consists of 150-250 words written in one paragraph, containing the essence of the manuscript, background, research objectives, methods, results, and conclusions. Results: Biology education material that has developed since there were three changes to the curriculum in Indonesia after the issuance of Law Number 20 of 2003 concerning the National Education System does not appear to have shown any significant changes specifically in the subject matter for class X SMA. Curriculum policies and the development of textbooks in Indonesia focus more on and continue the material in the previous curriculum since the emergence of the competency-based curriculum (2004). Conclusions: The development of biology education in Indonesia from materials, textbooks, and curriculum policies does not show a significant change and development in the development of biology science for class X SMA. This study concludes that textbooks and curriculum policies have not been able to change the perspective and substance of the direction of learning biology in Indonesia. So the portrait of the capacity and insight of the Indonesian generation's knowledge about biology can be seen from the curriculum policies and the existing materials.
Viva en la guerra, agonizante en la paz
Authors: Galaz-Mandakovic Fernández Damir
Published: June 2023

Se caracteriza el desarrollo de la minería del manganeso chileno en general, viendo el caso del Norte Chico en particular, considerando las derivaciones y el impacto regional de la demanda del mercado global que fue modelado por las exigencias de la guerra, situación que representó un hito de oportunidad para el desarrollo para una minería estratégica, pero que también se caracterizaba por su condición feble, de productividad zigzagueante y con modos de producción que resultaban precarios. De esa manera, el contexto bélico estimuló un proceso de explotación intensiva, donde el Estado tuvo una importante participación a través de la Corporación de Fomento de la Producción (CORFO) y la Caja de Crédito y Fomento Minero (CACREMI), buscando de ese modo, apoyar y promover una minería mediana que vehiculizó la inscripción global del Norte Chico en una escena de conflictos.
How does the green competitive advantage of building a sustainable palm oil industry? The role of green innovations as a mediation
Authors: Hendarjanti Henny , Nawangsari Lenny Christina
Published: June 2023

This study aims to analyze how green intellectual capital (GIC), green organization culture (GOC), and green information technology and system (GIT) impact corporate sustainability (CS) through green competitive advantage (GCA) with green innovation (GI) as an intervening variable. This study used a partial least squares structural equation model (PLS-SEM) model to test the conceptual model using SmartPLS version 3 on a sample of 220 employees in the palm oil industry of PT Astra Agro Lestari Tbk. The result shows that GIC, GOC, and GIT have an effect on GI and GCA, and further, GCA has proven to affect CS. Therefore, the Oil Palm Corporate that can create GI will get GCA and CS. Thus, it will increase the image of the company. Furthermore, applying GIC, GOC, and GIT will improve the application of GI, thereby reducing carbon emissions and the impact of environmental damage due to the company’s business processes. Therefore, companies with GI continuously will improve the quality of green and have GCA. The relevant article also proclaimed comparable research conclusions. GI contributes positively to developing a competitive advantage for the company (Maziriri & Maramura, 2022).
POOLPARTY2: An integrated pipeline for analyzing pooled or indexed low coverage whole genome sequencing data to discover the genetic basis of diversity
Authors: Willis Stuart , Micheletti Steven , Andrews Kimberly , Narum Shawn
Published: June 2023

Whole genome sequencing data allow survey of variation from across the
genome, reducing the constraint of balancing genome sub-sampling with
recombination rates and linkage between sampled markers and target loci.
As sequencing costs decrease, low coverage whole genome sequencing of
pooled or indexed-individual samples is commonly utilized to identify
loci associated with phenotypes or environmental axes in non-model
organisms. There are, however, relatively few publicly available
bioinformatic pipelines designed explicitly to analyze these types of
data, and fewer still that process the raw sequencing data, provide
useful metrics of quality control, and then execute analyses. Here, we
present an updated version of a bioinformatics pipeline called
POOLPARTY2 that can effectively handle either pooled or indexed DNA
samples and includes new features to improve computational efficiency.
Using simulated data, we demonstrate the ability of our pipeline to
recover segregating variants, estimate their allele frequencies
accurately, and identify genomic regions harboring loci under selection.
Based on the simulated data set, we benchmark the efficacy of our
pipeline with another bioinformatic suite, ANGSD, and illustrate the
compatibility and complementarity of these suites by using ANGSD to
generate genotype likelihoods as input for identifying linkage outlier
regions using alignment files and variants provided by POOLPARTY2.
Finally, we apply our updated pipeline to an empirical dataset of low
coverage whole genomic data from uncurated population samples of
Columbia River steelhead trout (Oncorhynchus mykiss), results from which
demonstrate the genomic impacts of decades of artificial selection in a
prominent hatchery stock.
Reassortant Eurasian Avian-like H1N1 Influenza Viruses from Diseased Swines, Southern China
Authors: Yan Jianhua , Wang Jiayu , Kong Zirong , Sun Xiangxiang , Li Sanmu , He Qisong , Sun Wenbo , Xiong Yi
Published: June 2023

958 lung tissue samples of swine influenza were collected in Guangxi
from 2013 to 2014 to further study the pathogenic mechanism and
prevention and control technology of influenza virus, and influenza
virus isolation and biological characteristics analysis of Eurasian
avian influenza (ER-H1N1) were performed. The positive rate of the 14
strains of ER-H1N1 swine influenza virus isolated was 1.46%, with 8
gene pieces all from avian sublineages, followed by recombinant Pdm/09
H1N1 fragments. Although their HA cleavage site is PSIQSR↓GLF or GIF,
which has typical low-pathogenicity characteristics, the isolated virus
strain grows well on the cell, and after the BALB/c mouse challenge
experiment, the evidence of the isolated strain multiplying in the
respiratory tract of mice is obvious, and the mice lose weight quickly,
all die within a week and are accompanied by severe systemic infection.
Based on changes in the amino acid residues of the
A/swine/Guangxi/6/2013 (No.6) strain, it is thought that the NA protein
E119G mutation is the main site where highly dangerous changes happen. D
N mutations in the PB2 strains G2, g14, g21, g30,
S2, 32, 7, and 8 show that these strains are gradually adapting to human
sources. According to the traits of strains 30, G2, G14, and G21, NP
develops 375 , which boosts
pathogenicity. In summary, the ER-H1N1 subtype influenza virus is
widespread in the Guangxi swine herd, and it is pathogenic to mice, with
the trend of genomes derived from Pdm/09 H1N1 fragments increasing.
Enhancing Lithium-Air Battery Performance through CoPc@CNT Composites: Electrochemical Analysis and Insights
Authors: Yerlikaya Gurbet , FARSAK Murat
Published: June 2023

Cobalt-phthalocyanine (CoPc) catalysts have shown great promise for
enhancing the performance of lithium-oxygen (Li-O2) batteries, offering
benefits such as efficient lithium storage, high reversible capacity,
improved cycle performance, and enhanced charge and discharge capacity.
In this study, we focused on the synthesis of CoPc-carbon nanotube (CNT)
composites with porous structure. The composites were prepared by
synthesizing CoPc compounds and interacting them with CNTs using a 3D
ball mill shaker. Comprehensive spectroscopic techniques including NMR,
FTIR, and UV were employed to characterize the newly synthesized
phthalonitrile and phthalocyanine compounds. The surface morphologies of
the composite materials were investigated using SEM, EDX, mapping and
TEM analysis, enabling the determination of particle sizes and chemical
compositions. XRD and XPS analyses confirmed that the composite
structures were consistent with the existing literature. BET analysis
revealed multilayer isotherm for the composites, indicating their
favorable properties. The composite catalysts were incorporated into
batteries and their performance was evaluated through various
electrochemical tests. Notably, the CoPc1-CNT composite exhibited a
remarkable discharge capacity of 3400 mAh g-1catalyst in the prepared
battery.
Molecular and biochemical characterization of solid waste biodegrading microbes isolated from municipal waste dump site
Authors: Afshan Naheed , Ghouri Maham , Hayat Aliya , Nadeem Sayyada Ghufrana
Published: June 2023

Solid waste dump site-based pollution is one of the colossal health concerns globally due to presence of cellulose, starch, protein, and lipids, which is a perfect nutrient waste for the development of biodegrading potential microbes. The current study aimed to determine the productive microorganisms for waste biodegradation. Ten samples were collected from different areas of Karachi waste dump sites. The identification and characterization of isolates were done by morphological and biochemical tests. The isolated microbes were qualitatively screened for the action of making industrially key bio-enzymes. The potential enzymes producing microbes were subjected to waste degradation test for 90 days. Changes of odor, color and weight loss of decomposing garbage were noted. The highest degradation ability in term of weight loss was shown by Aspergillus (SSI14) and Bacillus (SSI6). Four metals (zinc sulphate, cadmium chloride, copper sulphate and iron sulphate) were chosen for the purpose of metals tolerance test and minimum inhibitory concentration (MIC) of the isolated microbial strains. Current study reported that Zn was found to be more lethal in in comparison to  Cu and Fe. Molecular identification of the isolated microbes was done by polymerase chain reaction. The microbial strains were characterized by the polymerase chain reaction (PCR) followed by confirmation of product by agarose gel electrophoresis. The findings can be served as baseline data to develop microbial apparatus for biodegradation and management of solid waste.
Application of Reactive Artificial Intelligence Model to Predict Malicious Activities
Authors:   1 Washington University of Science and Technology, Vienna, VA, 22182, USA 2 Washington University of Science and Technology, Vienna, VA, 22182, USA 4Northumbria University, New Castle, NE1 8ST, UK 4University of Indianapolis, IN, 46227, USA, Yamcharoen P. , Folorunsho O.S. , Bayewu A. , Ojo T.P.
Published: June 2023

The critical infrastructure in the United States have been attacked countless time, and the federal, state, and private entities are concerned with securing their network infrastructure and sensitive data to prevent revenue loss and intellectual properties. Billion dollars are lost to cyberattacks globally, and the United States tops the list of countries that recorded more cyber-attacks. The healthcare industries have lost revenue due to litigation from compromised patient data and revenue paid as a ransom to cyber attackers. Integrating a reactive artificial neural network model into their cybersecurity architecture will monitor the activities of users' activities internally or externally accessing the organization's resources. The Newton method algorithm was applied to predict the malicious activities and the performance of the model support derivative matrix from the input variables that were used to train the model. The validation result of the algorithm has proven that an artificial neural network model can be deployed and integrated into the cybersecurity solution to predict the likelihood of an attack. Keywords: Healthcare, Cybersecurity, Artificial Intelligence, Threat Actors, Risk Assessment. Yamcharoen P., Folorunsho O.S., Bayewu A. & Ojo T.P. (2021): Application of Reactive Artificial Intelligence Model to Predict Malicious Activities. Journal of Advances in Mathematical & Computational Science. Vol. 9, No. 2. Pp 61-68. DOI: dx.doi.org/10.22624/AIMS/MATHS/V9N2P5 Available online at www.isteams.net/mathematics-computationaljournal.
C9orf72 genetic screening in amyotrophic lateral sclerosis patients from Serbia
Authors: Marjanovic Ana , Palibrk Aleksa , Dobricic Valerija , Milicevic Ognjen , Brankovic Marija , Viric Vanja , Drinic Aleksandra , Mandic-Stojmenovic Gorana , Jankovic Milena , Basta Ivana , Peric Stojan , Novakovic Ivana , Stefanova Elka , Stevic Zorica
Published: June 2023

Hexanucleotide repeats expansion in the C9orf72 gene is the most common cause
of familial and sporadic amyotrophic lateral sclerosis (ALS) cases in
Europe. In this study we aimed to determine the size and distribution of
C9orf72 alleles, and investigate the possible association of the repeat size
with several clinical parameters in ALS patients from Serbia. Patients were
recruited from 2011-2021 and analysed using fragment length analysis and
Southern blot. Out of 383 ALS patients, we have detected 31 (8.09%) patients
with repeat expansion. In the total ALS cohort, clinical overlap with
frontotemporal dementia (FTD) was registered in 17 (4.44%) patients, and
among them, 5 (29.41%) were expansion carriers. There was no difference in
the age of onset, age at the examination or disease duration, gender, and
the frequency of spinal and bulbar onset between patients with and without
C9orf72 expansion. The presence of positive family history (34.48% vs.
15.65%) and FTD (16.13% vs. 3.41%) was more frequent in expansion-positive
vs. expansion-negative patients. In expansion-positive patients,
significantly higher values of the largest detected repeat were found in
patients with ALS in the family, and in expansion-negative, a higher median
value of the smaller allele was noted in patients with a positive family
history of ALS, dementia, and both in comparison to the rest of the group. A
correlation of the repeat size was not found with the age of onset in both
patients with and without the expansion. This is the first detailed study of
C9orf72 sizing in ALS patients from Serbia. Our results emphasize the need
for C9orf72 genetic screening in ALS patients with/without FTD.
HOTAIR/miR1 axis acts as a potential chemotherapy target in gastric cancer
Authors: Ghanadpour Morteza , Kazemi Nezhad , Galehdari Hamid , Hajjari Mohammadreza
Published: June 2023

Gastric cancer is one of the most common cancers in the world. Delayed
diagnosis is the most common cause of death in patients. Long noncoding RNAs
(lncRNAs) are a group of non-coding RNAs that are effective in the incidence
of cancers. Studies in different cancers determined HOTAIR as an important
lncRNA in tumorigenesis. In gastric cancer, the function of HOTAIR in the
initiation and progression of cancer seems to be crucial. In this study, we
confirmed the significant differential expression of HOTAIR between gastric
tumors and normal tissues in different datasets. In the following, the
regulatory function of HOTAIR and its interaction with miRNAs in development
of gastric cancer was analyzed. Our analysis determined that the
upregulation of HOTAIR is essential to different pathways associated with
the progression of gastric cancer. Further analysis determined numerous
miRNAs as potential targets for HOTAIR. Among them, we demonstrated miR-1 as
a significant miRNA with negative correlation with HOTAIR in gastric tumors.
Validation analysis determined that HOTAIR is a target of cisplatin as a
common chemotherapy drug. Eventually, the effect of cisplatin on the
expression of HOTAIR and its potential target, miR-1, was checked by an in
vitro study. Cisplatin treatment on the gastric cancer cell line showed that
there is a significant negative correlation between the downregulation of
HOTAIR and the upregulation of miR-1 in treated cells. In conclusion,
comprehensive in silico analysis and experimental study provided evidence
for the importance of the HOTAIR/miR-1 axis as potential diagnostic and
treatment strategies for gastric cancer.
Physicochemical substances and bioactive components of wild cornelian cherry (Cornus mas L.) fruits in Erzincan province of Eastern Turkey
Authors: Ozrenk Koray , Tas Akgul , Gundogdu Muttalip , Keskin Nurhan , Ercisli Sezai
Published: June 2023

Turkey has a very rich flora due to diverse climatic and topographic
conditions within the country. Cornelian cherry (Cornus mas L.) is an
important wild edible fruits and widely distributed in Turkey and well known
for its fruit antioxidants and nutrients. In this study, phytochemical
content in fruits of a number of Cornelian cherry genotypes in Erzincan
region were determined. The biochemical analysis included organic acids,
sugars, vitamin C, antioxidant and individual phenolic compounds. In the
study, organic acid content was between 253.09 mg/100 g and 112.50 mg/100 g.
Vitamin C content varied between 115.85 mg/100g and 43.77 mg/100 g.
Likewise, the sugar content of Cornelian cherry fruits varied from 6.17
g/100 g to 4.06 g/100 g. When the antioxidant content was examined, the
highest antioxidant was 980.91 ?mol TE/g fresh weight (FW) base and the
lowest was 490.38 ?mol TE/g FW. In the genotypes examined, gallic acid was
determined as the highest among the individual phenolic compounds, while the
individual phenolic amounts ranged from 38.93 mg/100 g FW to 4.31 mg/100 g
FW. As a result of the study, it was determined that Cornelian cherry fruits
are very rich in vitamin C and other phytochemicals and as a result of this
examination, 24ER04 and 24ER08 genotypes came to the fore.
Text-11 snps and neighboring sequences role in causing male infertility in some ethnic groups of Iranian and their potential role in estimating divergence time
Authors: Sheidai Masoud , Allahverdi Sogol , Anvari Narges , Khamene Somayeh , Alavijeh Mozhgan , Ghoreishi Marziyeh , Jamshidi Fatemeh , Khosravani Ghazal , Kalhor Naser , Koohdar Fahimeh
Published: June 2023

X-chromosome and its independent loci recently gained importance in genetic
investigations concerned with disease control-case studies, population
genetic analyses, and phylogenetic investigations. Infertility and lack of
normal reproduction are important issues in health. Aazoospermia is a kind
of infertility in men whose semen contains no sperm and can affect about
1-20% of the male population. The majority of cases of spermatogenic failure
in humans are idiopathic, and the underlying causes are postulated to be
genetic. We analyze the potential association between seven X-Chromosome
SNPs and the neighboring sequences with azoospermia in four ethnic
populations in Iran. We also carried out population genetic analyses to
produce data on genetic variability, population structure, gene flow, and
time of divergence in these ethnic groups, for the first time. As the
X-chromosome genes/SNPs are in homozygous condition, for the association
study we used multivariate statistical methods, which revealed the potential
role of variable sites close to the studied SNPs in male infertility.
Haplotype groups were identified for each of the seven SNPs. The results
showed gene flow among ethnic groups due to migration and inter-breeding and
Bayesian analysis of sequence data suggested divergence time for ethnic
populations to be between 2-30 KY.
Association studies in pea for yield and yield attributing traits
Authors: Kaur Hardeep , Dhall Rajinder , Sharma Priti
Published: June 2023

The present study was conducted to find out correlation and path analysis for
10 yield and yield attributing traits using 159 diverse pea genotypes.
Correlation studies revealed that the days to 50% flowering, node at which
1st pod appears, number of pods/plant, number of seeds/pod, pod length, pod
weight and days to 1st picking had significant and positive correlation with
total yield/plant while, plant height and shelling percentage were
negatively correlated with total yield/plant. The inter-correlation was
observed between days to 50% flowering, days to 1stpicking and node at which
1stpod appears; shelling percentage with number of seeds/pod and pod length;
plant height with number of pods/plant and days to 1st picking. It is
concluded that there is positive and inter-correlation of total yield/plant
with the number of pods/plant, pod length, number of seeds/pod, days to 50%
flowering, days to 1stpicking. The positive association suggested that
selection should be oriented towards more number of pods per plant, pod
length, more number of seeds per pod which would consequently leads to
higher pod yield per plant. The Path analysis studies revealed that the
number of pods per plant exhibit highest positive effect on yield per plant.
Perfil Antropométrico y composición corporal en Futbolistas de Elite Ecuatorianos según su posición de juego
Authors: Álvarez Córdova Ludwig Roberto
Published: June 2023

Introducción: La cineantropometría en deportistas es imprescindible para la valoración cuantitativa de su Composición Corporal (CC) y nutricional, llevándonos a una percepción personalizada permitiendo establecer objetivos y estrategias que convergen en el entrenamiento y la dieta, con el fin  de conseguir el éxito deportivo. Objetivo: Describir las caracteristicas antropométricas, la CC  y el somatotipo  específico por posición de juego en futbolistas profesionales de la primera división del Ecuador, con el propósito de establecer patrones antropométricos, que permitan en un futuro referenciar a la población de futbolistas y que pueda ser comparado con otros equipos profesionales Método: Se analizaron las variables antropometricas según protocol ISAK, de 30 futbolistas profesionales masculinos de un equipo de primera de la liga ecuatoriana de fútbol, evaluándose el somatotipo según Heath-Carter y su CC cálculándose la Masa Grasa (MG) de Yuhaz  modificada por Carter  y el cálculo de la Masa Libre de Grasa (MLG) y Masa Muscular (MM) por Lee; empleándose una estadística descriptiva (media±desviación estándar (Ds)) a través de SPSS 25.0 aplicando t- Student bilateral pareada (two-tailed paired t test) (P<0.005). Resultados:  Los valores medios obtenidos son estatura (179±5,1 cm), peso (78±7,1 Kg), y la edad (25±5 años), siendo de mayor edad los centrocampistas y los de mayor altura los porteros y delanteros. Con respecto al IMC se obtuvo un valor de 24,9±2,2, siendo el valor medio de porcentaje de grasa corporal (%GC) de 13,1±3,3%, teniendo un valor superior los porteros y los defensas en menor proporción; con MLG 45,2 ±1,7%, con MG (9,8±2,9 Kg) y MM (66±,8Kg). El somatotipo es mesomorfo balanceado en todas las posiciones de juego (1,8 - 5,4 - 1,8). Discusión: Según su posición de juego, no existe diferencia entre los somatotipos con y con una CC acorde a lo publicado en este deporte deporte practicado.
Pemetaan Situasi Lingkungan dengan Total Station di Kampus Universitas Pendidikan Ganesha di Jinengdalem
Authors: I Gusti Putu Adi Susila  , Jayantara I Gst Ngr Yoga
Published: June 2023

Permukaan tanah ialah bagian dari ruang yang keberadaannya terbatas, oleh sebab itu diperlukan pemanfaatan permukaan tanah yang terencana dan terkendali. Dilihat dari hal tersebut maka akan di lakukannya pemetaan situasi yang meliputi pengukuran Infrastruktur dan Pengukuran Topografi di lingkungan kampus Universitas Pendidikan Ganesha yang berada di Provinsi Bali, Kecamatan Buleleng, Kabupaten Buleleng. pemetaan yang lebih detail akan Membutuhkan teknologi yang lebih canggih yaitu pemetaan dengan menggunakan alat Total Station (TS). Tujuan dari penelitian ini yaitu untuk memetakan lingkungan kampus UNDIKSHA Desa Jinengdalem dengan output yang di hasilkan berupa peta situasi dan untuk mengetahui bagaimana proses pembuatan bm baru menggunakan RTK. Metode pada penelitian ini yaitu dengan Pengumpulan data yang dilakukan dalam penelitian ini yaitu dengan melakukan pengukuran langsung di lapangan menggunakan alat TS dengan metode pengukuran Terestris polygon tertutup. Hasil penelitian ini berupa peta situasi lingkungan, peta topografi, dan hasil koreksi perhitungan ketelitian
Organization of foreign language adaptation training in a technical university during the pandemic
Authors: Маркова Наталия Александровна
Published: June 2023

Рассматриваются вопросы организации адаптационной иноязычной подготовки в российском техническом вузе в период пандемии COVID-19. Автор полагает, что общие объективные изменения вынужденного дистанционного образовательного процесса также характерны и для адаптационного обучения. Выявлены противоречия, возникшие в период обязательного дистанционного обучения и препятствующие достижению ожидаемых результатов в адаптационном обучении английскому языку на примере Томского политехнического университета. Обосновывается необходимость более углубленного изучения механизмов и принципов адаптационного обучения. Подчеркивается важность определения ключевых моментов, которые обеспечили успешное педагогическое сопровождение адаптационного курса в период пандемии. Делается вывод о том, что цифровая трансформация российской системы образования неизбежна, однако необходимо задуматься о системном подходе к построению новой образовательной среды.

In connection with the threat of the spread of a new coronavirus in March 2020, all Russian universities had to switch to a distance learning format. The mass transition to a distance format of training has revealed a number of problems and contradictions in the possibilities of implementing higher education programs in a distant form. This required a deep and detailed analysis of different aspects of distance training, the readiness of all participants in the educational process, the availability of material, technical and methodological support. The article considers the issues of organization of Foreign Language adaptation training in a technical university during the COVID-19 pandemic. The author believes that the general objective changes of compulsory distance training process are also typical for Foreign Language adaptation training. The contradictions emerged in this period are revealed on the example of Tomsk Polytechnic University. The article gives proof of the necessity of more in-depth study of the adaptation training mechanisms and principles. The importance of identifying the key points that ensured successful pedagogical support of adaptation course during the pandemic is emphasized. The conclusion is made that the digital transformation of the Russian education system is inevitable, but it is necessary to think about a systematic approach to building a new educational environment.
The essence and specifics of pedagogical support for preschool children with special educational needs
Authors: Акулова Елена Геннадьевна
Published: June 2023

В статье описана специфика педагогического сопровождения детей дошкольного возраста. Представлены теоретическое обоснование и методологические подходы педагогического сопровождения, его практическая значимость. Выделены сущностные характеристики, обозначены смыслы и значение педагогического сопровождения в дошкольном образовании. Выдвинут принцип диверсификации педагогического сопровождения и показана его взаимообусловленность с вариативностью образования в дошкольных организациях. Классифицированы основные процессы взаимодействия педагога и ребенка и отмечена динамика изменений в системе сопровождения дошкольников в связи с появлением в массовых образовательных учреждениях детей с особенностями в развитии. Дано расширенное понимание термина «дети с особыми образовательными потребностями» с позиции поддержки многообразия детства. Представлена классификация категорий детей с особыми образовательными потребностями, обучающихся в российских дошкольных организациях. Определены необходимые условия и перспективы развития педагогического сопровождения дошкольников с особыми образовательными потребностями в рамках вариативного социокультурного образовательного пространства.

The article describes the specifics of pedagogical support for preschool children. The theoretical substantiation and methodological approaches of pedagogical support, its practical significance are presented. The meanings and significance of the phenomenon are indicated, the essential characteristics of pedagogical support in preschool education are highlighted. The topic of personalization of education, development, upbringing of children with various starting opportunities is updated. The principle of diversification of pedagogical support is put forward and its interdependence with variability as an actual quality of Russian education is proved. The main processes of interaction between a teacher and a child are classified and the dynamics of changes in the system of support for preschoolers in connection with the appearance of children with developmental disabilities in mass educational institutions is shown. The term “children with special educational needs” is presented, which is disclosed from the position of supporting the diversity of childhood. Classification of categories of children with special educational needs studying in Russian preschool organizations has been developed. The necessary conditions and prospects for the development of pedagogical support for preschoolers with special educational needs within the framework of a multivariate socio-cultural educational space are determined.
Joe Biden’s Conceptual Metaphors: Framing His Rhetoric and Staging His Political Personae
Authors:   University of Klagenfurt, Pilyarchuk Kateryna
Published: June 2023

This research focuses on Joe Biden’s political personae framed by means of conceptual metaphors. His acceptance speech (21 August, 2020), victory speech (8 November, 2020), and inaugural address (21 January, 2021) serve as the primary data for the study. The texts are analyzed qualitatively, and metaphors are manifested following the Pragglejaz method. While discussing Biden’s resultant persuasive strategies, themes, and staged identities, references are made to metaphorical (self)-presentations by his predecessor, Donald Trump. The findings demonstrate that while Biden was hardly seen as a perfect candidate, his alternative rhetoric, emotional bonding with the public, inclusion of people into decision-making, and carefully constructed metaphorical roles (e.g., constructor, warrior, healer, author, traveler) helped him gain victory.
The Impact of Oral Health on Severity of COVID-19 Infection: A Cross-sectional Study of Recovered Patients in Syria
Authors: Mohamad Nebras
Published: June 2023

Purpose: This study aimed to investigate the role of oral health in determining the severity of COVID-19 infection among recovered COVID-19 Syrian patients.

Clinical Significance: The severity of COVID-19 infection varies among individuals, and the general health status of individuals plays a crucial role in determining the severity of symptoms. The association between oral health and COVID-19 severity has not been widely explored. Understanding the impact of oral health on COVID-19 severity can help in developing strategies to prevent severe and aggressive COVID-19 infection.

Material and Methods: A cross-sectional trial based on a questionnaire survey was conducted among 319 recovered COVID-19 Syrian patients. The questionnaire was divided into two main sections: oral health evaluation and COVID-19 severity assessment. Participants were classified into three groups based on their responses for oral health and COVID-19 severity.

Results: Our observations revealed a significant difference between overall health and the severity of COVID-19 infection. Participants with worse general health had higher COVID-19 severity index scores. Patients with chronic conditions also had a considerably higher prevalence of COVID-19 severity index. Furthermore, our findings suggest that individuals with poor overall health and chronic diseases exhibited the worst oral health. However, there was no relationship between oral health status and the recovery period of COVID-19 infection. The association between oral health status and COVID-19 severity index revealed a positive correlation, although it was not statistically significant.

Conclusions: Our study provides evidence that the oral cavity and its components may contribute to an elevated risk of COVID-19 infection, as the association between COVID-19 severity and oral health status revealed a positive correlation, although it was not statistically significant. Further research with larger sample sizes and more reliable study designs will be required to confirm our findings. In the light of our findings, we recommend following simple oral health measures such as tooth brushing, regular dental check-ups, and periodontal screening to prevent severe and aggressive COVID-19 infection.
Pragma-Translation Strategies of Emphasis Constructions in the Holy Quran
Authors: Mohammed Adyan Abdul-Munim , Kadhim Basim Jubair
Published: June 2023

This study examines the emphasis constructions used in the Holy Quran and the strategies used to translate them into English. While the Quran's emphasis constructions are considered miraculous, there is a shortage of English-language resources on this topic. The study's goals are to demonstrate the purpose behind the use of emphasis in the Quran and to identify the strategies used to translate emphasis constructions accurately. The analysis of five representative verses in the Quran reveals that Arabic has a stronger emphatic power than English, resulting in potential losses during translation. The study highlights the importance of context in interpreting emphasis devices and offers insights into the training of Quranic translators. Overall, this research sheds light on the translation of emphasis construction in the Holy Quran and emphasizes the need for accurate translations to fully understand Allah's original message.
In vitro Antimicrobial Activities, Qualitative Phytochemical Screening, and Free Radical Scavenging Capacities of Gymnanthemum myrianthum
Authors: Zacchaeus Rotich K. , Richard Kagia
Published: June 2023

Various members of the genus Vernonia are commonly used in traditional medicine to treat fever, malaria, diarrhoea, dysentery, hepatitis, cough, fertility inducer and as a laxative. Vernonia myrianthum (Gymnanthemum myrianthum) is one of the medicinal plants used by traditional healers in Uasin-Gishu and Elgeiyo Marakwet counties to treat communicable and non-communicable diseases such as diabetes mellitus. The objectives of this study were to evaluate the phytochemicals, free radical scavenging capacity and antimicrobial activities of the methanolic root extract of Vernonia myrianthum. Standard phytochemical screening methods were employed to qualitatively evaluate the classes of phytochemicals present in the plant. The anti-oxidant capacity was evaluated using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. The disc diffusion method and minimum inhibitory concentration (MIC) were used to screen for antimicrobial activity against Escherichia coli and Staphylococcus aureus. Vernonia myrianthum was found to contain secondary metabolites such as alkaloids, flavonoids, tannins, terpenoids, carotenoids, and coumarin. The antioxidant activity on the extract as based on its IC50 values indicated good antioxidant activity. There was no significant difference (p≥0.01) between the zones of inhibition of Vernonia myrianthum and those of those of the positive control gentamycin (GEN, at 10 mcg) and amoxicillin (AMC, 30 mcg) at various test concentrations demonstrating that V. myrianthum could inhibit the growth of E. coli and S. aureus. The   findings of this study are critical in understanding and documenting the phytochemistry, the antimicrobial properties and the antioxidant capabilities of V. myrianthum thus, laying the groundwork for future research on isolating bioactive compounds from these plants, as well as building the body of evidence needed to justify the ethnomedicinal usage of this plant in the treatment of numerous diseases by different communities.
Numerical Investigation on the Behavior of Eccentrically Loaded LWRC Columns at Elevated Temperature
Authors: Al-Thairy Haitham , Al-Naqeeb Faaiza
Published: June 2023

In this paper, a numerical model is presented to simulate the behavior and failure of LWRC columns subjected to eccentric compressive load at elevated temperature using the finite element code ABAQUS. Validation of the numerical model was ensured throughout comparison numerical results with the available published experimental tests results. The validated numerical model was implemented in conducting extensive parametric study to understand the effects of important parameters on the response of eccentrically compressed LWRC column at elevated temperature. These parameters include effect of increasing the concrete cover, effect of changing the exposure time, effect of increasing the exposed temperature, effect of temperature distribution around column section, effect of temperature distribution along column length, and effect of eccentricity ratio. The numerical results indicated that increasing the concrete cover of the column section results a considerable increasing of the ultimate load capacity. In addition, there is an increase in the ultimate load capacity when the temperature exposure time is reduced to the half, whereas, if the exposure period is increased to twice and three times the original exposure time, the ultimate load shows a slight decrease. Moreover, the ultimate load capacity of the LWRC column decreases when temperature is increased. Finally, the ultimate load capacity increased of the LWRC column when the temperature is distributed over larger distance of the column length
PROFILE PULMONARY ENDURANCE AND ANTHROPOMETRY OF TAEKWONDO ATHLETES
Authors: Melani Ida , Syafaruddin Syafaruddin , Yusfi Herri
Published: June 2023

This study aims to determine the results of cardiopulmonary endurance and anthropometry in the South Sumatra TPC taekwondo dojang athletes. This type of research is descriptive. The population of the study were TPC taekwondo athletes, totaling 30 athletes. The sample in this study was taken from the whole or total sampling, namely 30 athletes. The data analysis technique was processed with the percentage of data obtained, namely for the results of cardiopulmonary endurance athletes have an average cardiopulmonary endurance in the very good category, and for anthropometric results on body mass index have an average condition that is in the good category, for the circumference The athlete's upper arm circumference is in the good category, and the average athlete's abdominal circumference is in the good category. The implementation of this study is that if athletes have good cardio-pulmonary endurance and anthropometry, it will affect the results of sports achievements, especially in taekwondo sports.
Pendekatan Nanoteknologi Untuk Penghantaran Bahan Aktif Farmasi Dalam Terapi Acne Vulgaris
Authors: Anggraeni Dila , Kaniawati Marita , Jafar Ganardi
Published: June 2023

Jerawat (Acne vulgaris) adalah kelainan kulit yang terjadi akibat penumpukan sebum yang dihasilkan oleh kelenjar minyak yang ada di kulit. Penumpukan sebum tersebut akan menstimulus pertumbuhan P. acne yang akan menyebabkan pertumbuhan jerawat. Terapi untuk jerawat telah banyak dikembangkan untuk berbagai bahan aktif dan metode yang digunakan sudah beragam dari yang konvensional hingga teknologi terbarukan. Penghantaran terbarukan seperti nanoteknologi dipilih karena dapat meningkatkan stabilitas bahan aktif, meningkatkan penetrasi pada kulit serta dapat menghantarkan zat aktif ke daerah terapi yang tertarget. Tujuan: review yang disusun untuk menjadi bahan acuan komprehensif mengenai jerawat. Metode: metode yang digunakan adalah pengumpulan artikel ilmiah dari sumber nasional dan internasional. Hasil: hasil yang didapatkan adalah metode nanopartikel adalah metode yang paling baik dalam penghantaran sediaan topikal khususnya untuk terapi jerawat. Adapun berbagai pengembangan terbarukan yaitu lipid nanopartikel, polimer nanopartikel dan metal nanopartikel. Review ini akan mengulas secara lengkap berbagai studi mengenai penghantaran terbarukan zat aktif dalam penghantaran nano teknologi untuk terapi jerawat. Kata Kunci: Jerawat, Kulit, Nanopartikel,
Editorial Preface
Authors: Nurdin Nurdin
Published: June 2023

Editorial PrefaceNurdin Nurdin, Institut Agama Islam Negeri (IAIN) Palu
Análisis psicométrico de la Escala de Estrés Percibido (PSS-14 y PSS-10) en un grupo de docentes de Copiapó, Chile
Authors: Jorquera-Gutiérrez Ricardo , Guerra-Diaz Felipe
Published: June 2023

Antecedentes: el estrés percibido hace referencia al grado en que las personas perciben las demandas de su entorno como impredecibles e incontrolables. Las escalas PSS-14 y PSS-10 son los instrumentos más utilizados a nivel mundial para evaluar este constructo. Objetivo: describir las propiedades psicométricas de la EEP de 14 y 10 ítems en docentes chilenos, e indagar la invarianza estructural de sus modelos según el sexo de los/as docentes. Método: se efectuó un estudio instrumental en una muestra de 206 profesores. Resultados: el análisis factorial confirmatorio, a través de un método de máxima verosimilitud robusto (MLR), mostró los mejores indicadores de ajuste en los modelos de dos factores relacionados: en el PSS-14 (X2 = 166.693, gl = 76, p < .001; CFI = .918; TLI = .901; RMSEA = .076) y en el PSS-10 (X2 = 59.979, gl = 34, p < .001; CFI = .968; TLI = .957; RMSEA = .061). Los coeficientes ω McDonald’s fueron favorables para los factores de ambas escalas. Asimismo, se constató la invarianza de la estructura de dos factores para hombres y mujeres en los dos instrumentos. Conclusión: se concluye que estos antecedentes avalarían el uso de estos instrumentos en docentes chilenos.
Contribución de autoríaRJG y FGD: todos los autores participaron en la redacción y revisión del manuscrito.
Pengaruh Implementasi IFRS dalam Indeks Gray Terhadap Pengungkapan Laporan Keuangan
Authors: Aminajamiah Siti , Sumardi Sumardi , Nugroho Arif Widodo
Published: June 2023

Penelitian ini bertujuan untuk mengetahui pengaruh implementasi IFRS terhadap pengungkapan laporan keuangan yang diproksikan dengan indeks gray. Variabel yang diteliti dalam penelitian ini adalah indeks gray leverage, likuiditas, profitabilitas, solvabilitas, dan porsi saham publik. Sedangkan pengungkapan laporan keuangan diukur dengan menggunakan Indeks Wallace. Penelitian ini menggunakan metode kuantitatif dengan data sekunder diperoleh dari BEI dan website perusahaan. Populasi penelitian yaitu perusahaan manufaktur sub sektor food beverage yang terdaftar di Bursa Efek Indonesia (BEI) untuk tahun penelitian 2016 – 2020 dengan sampel penelitian berjumlah 60 data yang terdiri dari 12 (dua belas) perusahaan. Metode untuk mengestimasi persamaan regresi menggunakan fixed effect model. Hasil penelitian menunjukkan bahwa indeks gray leverage, likuiditas, profitabilitas, dan solvabilitas tidak berpengaruh terhadap pengungkapan laporan keuangan. Sedangkan indeks gray porsi saham publik berpengaruh positif terhadap pengungkapan laporan keuangan.Kata kunci: Indeks gray leverage; likuiditas; profitabilitas; porsi saham publik;solvabilitas dan pengungkapan laporan keuangan.
The uselessness of cytochrome oxydase gene analysis for genetic identification of selected Gobiidae species from some European countries
Authors: Kiełpińska Jolanta , Czerniejewski Przemysław , Adamkowska Natalia , Uzunova Eliza
Published: June 2023

The family Gobiidae is the largest teleost family, consisting of more than 2,000 species in more than 200 genera. They have adapted to a wide range of habitats, inhabiting mostly marine and brackish waters. Recently invasive Ponto-Caspian gobies have caused significant changes to the structure of fish assemblage throughout the European waters. The aim of the study was to verify the possibility of identifying three species of the genus Gobiidae based on the analysis of the mitochondrial region of the cytochrome oxidase subunit 1 (COI) gene. 339 samples originated from seven countries and 17 different sites were investigated. Qualitative and quantitative assessment of the extracted DNA was conducted by measuring light absorbance and electrophoretic separation. Approximately 650-bp (base pairs) fragments were amplified from the 5' region of the mitochondrial COI with the PCR (polymerase chain reaction) reaction. Sequences of 652 bp were obtained and compared with reference sequences in the National Center for Biotechnology Information (NCBI). Based on the sequence analysis, we determined that in the analysed geographical regions, the goby preliminary identified morphologically as the round goby was represented by three species: round goby ( Neogobius melanostomus), tubenose goby ( Proterorhinus marmoratus), and monkey goby ( Neogobius fluviatilis). The latter two are newly reported for their new habitats. Genetic characterisation of such populations offers the opportunity to assess their genetic stability, which provides agencies managing the aquatic environment in EU countries with a tool for revising the legislation, including regulations relevant for updating the status of native and invasive species in European waters.