bluuebunny/crossref_metadata_2025 huggingface dataset:
A hyperinflammation clinical risk tool, HI5-NEWS2, stratifies hospitalised COVID-19 patients to associate risk of death and effect of early dexamethasone in an observational cohort
Authors: Ardern-Jones Michael R. , Phan Hang T. T. , Borca Florina , Stammers Matt , Batchelor James , Reading Isabel C. , Fletcher Sophie V. , Smith Trevor , Duncombe Andrew S.
Published: January 2023

Background

The success of early dexamethasone therapy for hospitalised COVID-19 cases in treatment of Sars-CoV-2 infection may predominantly reflect its anti-inflammatory action against a hyperinflammation (HI) response. It is likely that there is substantial heterogeneity in HI responses in COVID-19.

Methods

Blood CRP, ferritin, neutrophil, lymphocyte and platelet counts were scored to assess HI (HI5) and combined with a validated measure of generalised medical deterioration (NEWS2) before day 2. Our primary outcome was 28 day mortality from early treatment with dexamethasone stratified by HI5-NEWS2 status.

Findings

Of 1265 patients, high risk of HI (high HI5-NEWS2) (n = 367, 29.0%) conferred a strikingly increased mortality (36.0% vs 7.8%; Age adjusted hazard ratio (aHR) 5.9; 95% CI 3.6–9.8, p<0.001) compared to the low risk group (n = 455, 36.0%). An intermediate risk group (n = 443, 35.0%) also showed significantly higher mortality than the low risk group (17.6% vs 7.8%), aHR 2.2, p = 0.005). Early dexamethasone treatment conferred a 50.0% reduction in mortality in the high risk group (36.0% to 18.0%, aHR 0.56, p = 0.007). The intermediate risk group showed a trend to reduction in mortality (17.8% to 10.3%, aHR 0.82, p = 0.46) which was not observed in the low risk group (7.8% to 9.2%, aHR 1.4, p = 0.31).

Interpretation

Higher HI5-NEWS2 scores measured at COVID-19 diagnosis, strongly associate with increased mortality at 28 days. Significant reduction in mortality with early dexamethasone treatment was only observed in the high risk group. Therefore, the HI5-NEWS2 score could be utilised to stratify randomised clinical trials to test whether intensified anti-inflammatory therapy would further benefit high risk patients and whether alternative approaches would benefit low risk groups. Considering its recognised morbidity, we suggest that early dexamethasone should not be routinely prescribed for HI5-NEWS2 low risk individuals with COVID-19 and clinicians should cautiously assess the risk benefit of this intervention in all cases.
I won’t listen if I think we’re losing our way: How right-wing authoritarianism affects the response to different anti-prejudice messages
Authors: Bouguettaya Ayoub , Vergani Matteo , Sainsbury Chloe , Bliuc Ana-Maria
Published: January 2023

Prejudice reduction messages have been shown to be effective through changing norms. Previous research suggests that Right Wing Authoritarianism (RWA) moderates the reaction to these messages, but it is unclear whether individuals high in RWA are more or less sensitive to prejudice-reduction campaigns. This research used the social identity approach to investigate the role of RWA in moderating the reactions to messages that look to reduce support for prejudicial policies and associated prejudice against an ethnoreligious group (Muslims). Americans (N = 388) were presented with statements on a real, proposed ban on Muslim immigration into the US from an in-group member (i.e., an American freight worker who disapproves of the Muslim ban), outgroup member (an Iraqi refugee who is in favour if the Muslim ban), or both, or control message. Those high in RWA showed consistently high levels of prejudice against Muslims in all conditions, but those low in RWA showed lower prejudice when presented with the anti-prejudice message from an in-group member (compared to control). This suggests that anti-prejudice messages primarily affect those with low RWA, clarifying that RWA likely leads to resistance to anti-prejudice messages regardless of the source. Future research aiming to reduce prejudice should examine how messages can be tailored to reduce prejudice in those with high RWA.
Consciously building bridges: Team-teaching to merge and evolve actor training in voice and movement
Authors: Calvano J. Ariadne , Carter Rachel K.
Published: January 2023

Successful integration of acting, voice and movement has long been desired in theatre-arts training. Existing systems, however, often offer three distinct and separate areas of performance training – at least within US higher-education curricular contexts. But, this article proposes, in team-teaching, we gain an experience of living the integration, of challenging the ways we traditionally teach exercises and of finding new ways to rework concepts and exercises taught to us. Consciously creating bridges across areas of training enables students to grow by experiencing two perspectives in the same classroom. Integration is the aim of a new ‘Introduction to Voice and Movement’ course created and team-taught by the authors of this article, a voice professor and a movement professor. We sought not only to merge voice and movement training within our university theatre department, but to re-evaluate how we approach teaching voice and movement. The experience became more than simply integrating voice and movement into one class. The discovery of pedagogical alignment resulted in the merging of two personal pedagogies. This merging became integration as students carried the physio-vocal training into their lives and artistry beyond the classroom.
‘Take it away, sure ’tis your own’: Negotiating authoritative voice in Irish traditional song performance through autoethnography
Authors: Fahey Hannah
Published: January 2023

This article discusses the authoritative voice in traditional Irish singing, examining voice in negotiation with prevailing and conflicting ideologies of practice in this context. Opening with a discussion on vocal identity and vocality in traditional Irish singing, autoethnography is used to present and critically examine an individual process of learning and voicing a macaronic song from the Irish tradition. Findings contribute to further understand the social, participatory and presentational dimensions of Irish traditional song as it is learned, performed and transmitted. Issues of vocal enculturation, identity and construction are negotiated as authoritative voice and stylistic efficacy are conceptualized in voicing Irish traditional song.
The sound of age in musical theatre: A conversation with musical theatre’s ageing female performers
Authors: Rigopoulou Faye
Published: January 2023

When does musical theatre consider an ageing female voice to be an ‘old(er)’ voice? What is the ‘expected’ voice quality for ageing female performers and what does it take to still be considered for roles after ‘a certain age’? This Voicing stems from a four-year doctoral research project that sought to identify and examine stereotypes, preconceptions and complexities that occur in the dramaturgy and performance of female ageing vocalities in musical theatre. Compiling extracts from research interviews with ageing musical theatre performers, it is composed in the format of a virtual round-table, and it aims to reveal and present, for the first time, the harsh realities of gendered ageing in musical theatre.
Major Labels: A History of Popular Music in Seven Genres, Kelefa Sanneh (2021)
Authors: Thomas Rob
Published: January 2023

Review of: Major Labels: A History of Popular Music in Seven Genres, Kelefa Sanneh (2021)

Edinburgh: Canongate Books, 464 pp.,

ISBN 978-1-83885-593-2, h/bk, £20
No Machos or Pop Stars: When the Leeds Art Experiment Went Punk, Gavin Butt (2022)
Authors: Bestley Russ
Published: January 2023

Review of: No Machos or Pop Stars: When the Leeds Art Experiment Went Punk, Gavin Butt (2022)

Durham, NC: Duke University Press, 282 pp.,

ISBN 978-1-47801-863-6, p/bk, £20.99
From Arthaus to Bauhaus, 1972–1979, Andrew J. Brooksbank (2021)
Authors: Bestley Russ
Published: January 2023

Review of: From Arthaus to Bauhaus, 1972–1979, Andrew J. Brooksbank (2021)

Stratford-upon-Avon: Tome & Metre, 284 pp.,

ISBN 978-1-83801-161-1, p/bk, £15.00
Mark Hollis: A Perfect Silence, Ben Wardle (2022)
Authors: Loydell Rupert
Published: January 2023

Review of: Mark Hollis: A Perfect Silence, Ben Wardle (2022)

London: Rocket 88, 368 pp.,

ISBN 978-1-91097-885-6, h/bk, £35.00
3D camera augmented Autonomous Mobile Robot for intralogistics
purposes
Authors: Hegedűs Alexandra , Simon János , Sárosi József
Published: January 2023

AMRs (Autonomous Mobile Robots) are driverless vehicles programmed
to perform a variety of tasks and are often used to transport goods or
materials. However, there can be several problems with the driving
performance of this type of vehicle. Safety in the workplace is important
everywhere, but there are some areas that are particularly exposed to
safety risks. Limited visibility is the main cause of accidents at work.
Yet, robots can map these dangerous areas with their sensors. We will
present a mobile robotic sensor development that can be implemented to
increase the security of robotic warehouses. Testing is necessary in order
to check the quality of existing defects in safety elements before delivery
and to carry out a risk assessment. Our goal was to add a safety element to
the robot to prevent the most common problem, namely it is colliding with a
forklift truck, hitting objects outside the sensor planes or hanging in.
Based on our experience with robots over the years, this has been a big
challenge, as we have had several such collisions. Therefore, we selected
and installed a modern 3D camera system and tested its compliance with the
safety requirements and the difference between the safety level of a robot
without 3D sensor (Alpha) and a robot with 3D sensor (Beta), based on the
knowledge of the installed camera.
perfil das pessoas em situação de rua no brasil e a importância da sua reinserção na sociedade
Authors: Santos Maria Vera dos , Silva Evania Souza e , Souza Luiza Catarina Sobreira de
Published: January 2023

Existe no Brasil uma média de 24.588 pessoas em situação de rua que estão incluídas em programas sociais, uma população que vive com menos de um dólar por dia e são considerados abaixo da linha da pobreza, não havendo contabilização do real número e características destes indivíduos pelos institutos responsáveis pelo senso populacional. Salienta-se, ainda, que essa população tem os vínculos familiares interrompidos ou fragilizados, sendo frutos de um longo processo de desigualdades e exclusão social. Os moradores de rua são tratados ora com compaixão ora com repressão, e mesmo sendo este assunto debatido há anos, ele não tem destaque na sociedade. Sendo assim, o objetivo desse trabalho foi tratar sobre a necessidade de reinserção dessa população na sociedade. Para tanto, adotou-se como método de abordagem o dedutivo e como procedimento metodológico o levantamento bibliográfico, sendo a pesquisa classificada como exploratória.
Application of strut-and-tie models for assessing RC half-joints not complying with current code specifications
Authors: Kotsovou Gregoria , Vougioukas Emmanouil , Cotsovos Demetrios M.
Published: January 2023

The work described is concerned with an investigation of the effectiveness of the use of strut-and-tie models for the structural assessment of half joints. Such elements form a part of many existing bridges which, although not complying with current code specifications, have not as yet displayed any significant signs of distress in spite of the increase in traffic volume and loads over the years. The work is based on a comparative study of the predicted and experimentally established values of load-carrying capacity and location and causes of failure of half-jointed beams with reinforcement layouts that replicate those found in structures designed in accordance with previous code specifications. The results obtained show significant shortcomings of the assessment method as this is found not only to underestimate load-carrying capacity by a margin ranging between 40 % and 65 %, but also to often fail to identify the location and causes of failure. Therefore, there is a need for an alternative assessment method that will be based on concepts capable of both providing a realistic description of structural-concrete behaviour and identifying the causes of failure leading to the loss of load-carrying capacity.
Conversion of units of length from the Czech state standard to the geodetic baseline Javoriv
Authors: Lechner Jiří , Kosarev Nikolai Sergeevich , Trevoho Igor Sergeevich
Published: January 2023

Modern society cannot do without high quality geospatial data. This need constantly strengthens with the growth of the information society and the emerging cyber society. Validity and quality of geospatial data is strongly connected to the level of its metrological service. It is necessary to conduct National metrological comparisons, in order to maintain an effective measuring infrastructure both inside a single country and in the whole Europe. The main result of such a comparison is a validation of actual values of key parameters of state standards.The article presents results of a conversion of unit of length of the state standard of the Czech Republic to the geodetic baseline Javoriv (Ukraine), as performed by the staff of the Research Institute of Geodesy, Topography and Cartography (RIGTC). The conversion was realised in cooperation with Lviv Polytechnic National University (Ukraine). High-precision measuring equipment used during the conversion includes: the Leica AT401 laser tracker and the Leica Nova MS50 electronic total station.A comparison of the measured length sections of the geodetic baseline Javoriv, performed by VUGTK employees, with the measurement results performed on a geodetic baseline Javoriv by specialists of the National Science Center (NSC) Institute of Metrology, gave a very good consistency. This is a sign of high quality results of comparative international measurement. It is planned to continue with the common efforts in the field of comparative international measurements between the Czech Republic and Ukraine in order to determine the actual values of the length sections of the geodetic baseline Javoriv.
Recommended procedure for headroom design according to geometric parameters of building structures
Authors: Veselá Linda
Published: January 2023

The system of Czech technical standards for geometric accuracy assumes that the designer determines the functional geometric parameters for a specific building. By calculation, he verifies them in the so-called “geometric plan” in the project documentation. The functional geometric parameters should be determined primarily for critical elements, i.e. for structures whose geometric accuracy is important for the execution of subsequent works, such as technologies requiring high precision and specific structures. The assumption is that designers will incorporate variations in geometric accuracy primarily in the development of the spatial parameters of the structures, which should ensure that the dimensional requirements for the completed structures will be met. One of these parameters is headroom. The design of headroom must respect the minimum height requirements prescribed by legislation, and where appropriate, by technical standards. At the same time, the design must respect the technological possibilities of the construction of individual structures – geometric deviations. To comply with the dimensional requirements for the completed structures, the geometric accuracy deviations should be determined in accordance with the requirements of the technical standards for the execution of the individual parts of the building structures and/or for their design. The aim of this article is to establish a calculation procedure for determining the safe design clearance so that the requirements of the legislation are met after implementation. The increase is determined based on a calculation procedure of the limiting geometric deviations that may affect the resulting headroom.
North isn’t necessarily up: map projections, the politics of cartography and their relevance to archaeology
Authors: Kratimenos Panos
Published: January 2023

Maps and mapping are indispensable tools within archaeological practice. However, they are also tools that have historically been employed relatively uncritically by archaeologists. Maps are used functionally, with little attention paid to the subtler impact of certain decisions in relation to form and appearance. This article serves as a companion to ‘A global perspective on the past: the Institute of Archaeology around the world’ piece earlier in this volume, briefly explaining the theoretical principles underpinning decisions taken in that piece. In particular, the relevance of developments in the field of critical cartography and their application to large-scale archaeological mapping are considered. Map projections, their history, relevant uses and the impact of the choice of projection are discussed, as well as the significance of map orientation. In particular, it is demonstrated that the normalised ‘north up’ visualisation of our planet is a very specific and surprisingly recent development with an important history and subconscious implications. The way in which space is visualised has a subtle impact on the way we understand and, therefore, behave in the world around us. As such, it is contended that a self-conscious and reflexive attitude to the way we visualise space is a crucial consideration in our understanding of both the present and the archaeological past.
Posłannictwo i zadania dziejowe rodziny. Transkrypcja myśli pedagogicznej Stanisława Wawrzyńca Staszica
Authors: Żywczok Alicja
Published: January 2023

In view of the fact that issues related to the family in the literary works of Stanisław Wawrzyniec Staszic are far less known than his socio-political views or his opinions about education, the author of this paper decided to creatively explore this treasure of Polish culture. The results of this study may significantly enhance the educational resources of sub-disciplines of teaching like familial teaching, the history of upbringing, the theory of upbringing and general teaching. Quoting from Stanisław Staszic, the author provides answers to several research issues, namely how Staszic perceived the family and what tasks (and missions) he assigned to family members, the parents and the offspring; the types of primeval families he identified (using the criterion of the law of nature); the role that he assigned to families with respect to the integration of mankind, the integration of a nation, and Poland regaining independence; the factors which, in his opinion, were the main obstacles to families undertaking historical tasks (including Polish families). In order to define these issues, the author of this paper used hermeneutic methods to interpret the literary output of Stanisław Staszic, revealing in the process the philosopher’s views on the family, its tasks, functions and the roles of its members, with special emphasis placed on the mother, father and the offspring. An analysis of the types of families in the initial phases of the existence of mankind was another effort worth making together with considering the obstacles that families encounter when carrying out their historical tasks
Wokół roku 1420. Początki szkolnictwa renesansowego we Włoszech
Authors: Zagrodzka Alicja
Published: January 2023

Paul F. Grendler suggested the year of 1420 as a symbolic date marking the dawn of Renaissance humanist teaching in the Latin education system. In 1420, the commune of Verona employed Guarino Guarini da Verona (1374–1460) to teach on the basis of Cicero’s letters and speeches. The anniversary has posed an opportunity to challenge a stereotype of two epochs: the Middle Ages and Renaissance, perpetuated in contemporary narration. I have presented my own image of these epochs, synthetic and simplified, yet based on historical facts. The synthetic approach to the similarities and differences between the Middle Ages and Renaissance, suggested here, is coherent with the changes which took place at the dawn of Italian Renaissance education (presented in the second part of the article). I have found out that this development was possible owing to personal contacts among humanists and their familiarity with inspiring texts. I have also discovered that before 1420, before Renaissance humanist education was introduced to public city schools, it had left its mark on self-education, informal relations, private city schools and urban home schooling. Only then did studia humanitatis became attractive to Italian communes and started to employ teachers knowledgeable about the new curriculum. The differences between the Renaissance and medieval education models in Italian public city schools include primarily the means at hand (i.e. the curriculum, the obligatory reading and partly the teaching organisation). They did not pertain to the major goals set by the then teachers (i.e. providing children and adolescents with knowledge and skills that they found useful in adult life, coupled with moral teaching and developing their habits). In my opinion, the Renaissance education model is continuation of the medieval model rather than its opposition because these two models complement each other harmoniously.
„Jak żyć po czymś takim w Polsce?” Edukacyjne walory podróży na przykładzie Dziennika podróży do Italii i Szwajcarii z lat 1815–1816 Rozalii Dunin-Borkowskiej
Authors: Sijka Katarzyna
Published: January 2023

A Diary of a Journey to Italy and Switzerland in 1815–1816 written by Rozalia Dunin-Borkowska is one of few preserved descriptions of a journey to Italy made by a Polish woman in the early 19th century. Rozalia and her husband Stanisław embarked on their expedition on 27 May 1815 in Lvov; they went to Italy and spent nine months there, from October 1815 to July 1816. The Italian tour started in Venice and included Padua, Bologna, Florence (twice), Rome, Naples, Milan and Geneva. The spouses spent the journey actively although their main goal was to learn about the culture of the Italian Peninsula. Undoubtedly, their time in Italy was filled with admiring the works of art and visiting the most famous art galleries in almost every city on the itinerary. Consequently, the journal is full of reflections on the aesthetic value of Italian works of art. Rozalia Dunin-Borkowska was an informed traveller: while she admired the sights and paintings, sculptures and other works of art, she did that in a thoughtful way. She needed quality time to form her own opinions. Her journal demonstrates very well that visiting foreign countries was an intellectually stimulating experience. Getting to know a new culture significantly broadened the horizons of 24-year-old Rozalia. As her journal suggests, she was well-prepared for her European journey. The outstanding lesson that she learnt allowed her to reap the rewards of the tour and satisfy her intellectual aspirations. The Diary is a great source of experience accumulated by a Polish traveller; it provides an opportunity to find out about Rozalia’s cultural life, her preparation for the journey and how the trip affected her. Furthermore, Dunin-Borkowska’s testimony was compared with Katarzyna Platerowa’s and Teofilia Morawska’s diaries due to the fact that all three of them shared certain common features. Namely, their cultural background, material status and, most importantly, the travel itinerary. They were all well prepared for their respective journeys; they were also well educated, fluent in foreign languages and, above all, they were curious about the world and interested in learning about a new culture. Each of these travellers was influenced by the European journey which provided educational values combined with unforgettable experiences.
Pedagogika specjalna jako przedmiot zainteresowania współpracowników lwowskiej „Szkoły” (w II połowie XIX wieku)
Authors: Wałęga Agnieszka
Published: January 2023

oldest pedagogical journal published in Galicia, Eastern Europe, in the last 30 years of the 19th century. To date, these problems have not been analysed in detail in literature on the subject. The journal, devoted in particular to teachers’ training colleges and folk schools, was recommended to teachers in the south of Poland (which at that time was a part of the Austro-Hungarian Empire) as an important means of self-education. It was emphasized that knowledge acquired in teachers’ training colleges had to be broadened and the candidates for teachers, as well as professional Galician educators, should do it on their own. This concerned, among other things, the knowledge of the idiosyncrasies of working with disabled pupils. An analysis of the annual volumes of the journal from 1868–1899 demonstrates that its editors and collaborators dealt with issues in the field of oligophrenopedagogy, education of the deaf and people with impaired hearing, education of the blind and social rehabilitation. Articles published in the journal familiarized the readers with the history and contemporary problems of special education. They also supplied valuable educational and methodological instructions for parents, guardians and teachers of disabled children.
Promocja czytelnictwa dzieci i młodzieży przez Wojewódzką Bibliotekę Publiczną – Książnicę Kopernikańską w Toruniu w latach 80. XX wieku
Authors: Lewandowska Martyna
Published: January 2023

The article presents activities undertaken by a Public Provincial Library – the Copernicus Library in Toruń in the field of promoting readership among children and adolescents in the 1980s. The author describes the situation of libraries after WWII and the role of librarians, emphasizing the educational aspect of their work. In addition, she recreates the course of seminars organised for librarians from children’s libraries, the curiculum of which included academic lectures including lectures on authors of books for children, an analysis of the status of readership and libraries and a discussion of the latest developments. The text includes a description of popularizing activities and initiatives. Cyclical library lessons and thematic projects like holiday and summer campaigns, are also described. The article is based mainly on historical source materials stored in the Archives of the Public Library and the State Archives in Toruń. They include documents relating to the institution, i.e. reports, characteristics of the directions of library development for selected years, as well as materials documenting library events and happenings.
Kefir fermented milk as starter culture in Minas Frescal cheese production
Authors: Alves Gilberto , Camaso de Sá Thaís , Souza Rocha Matheus , Silva Anderson Eduardo , Freitas Vieira Luiz Gustavo , Kazue Otutumi Luciana , Quessada Ana Maria
Published: January 2023

The present work aimed to produce Minas Frescal cheese with the replacement of the commercial lactic culture by fermented kefir milk with kefir (FKM) and verify some of its physicochemical characteristics, aiming mainly at the development of a new commercial probiotic dairy product with low production cost as compared to the use of commercial probiotic cultures. Kefir grains were added to whole UHT milk and fermented at 22ºC/24 hours in an incubator, after fermentation the grains were separated and the FKM was used in the manufacture of cheeses with the addition of 1, 3 or 5% of the total volume of milk. They were analysed the concentrations of fat and protein in the milk used in cheese manufacturing; the acidity of FKM, milk, FKM-added milk, whey and cheeses; in those ones their total solids (TS), fat and fat in the total solids (FTS) and manufacturing yields were evaluated. The results obtained indicated that it was possible to produce Minas cheeses using KFM in all of the tested concentrations because the results for all treatments were close to those found in the literature with the use of commercial lactic cultures and among the treatments only the acidity had significant differences, however more studies should be carried out mainly aiming at the standardization of kefir cultures for the industrial process of manufacturing these cheeses.
Goal-Directed Action Is Initially Impaired in a hAPP-J20 Mouse Model of Alzheimer’s Disease
Authors: Dhungana Amolika , Becchi Serena , Leake Jessica , Morris Gary , Avgan Nesli , Balleine Bernard W. , Vissel Bryce , Bradfield Laura A.
Published: January 2023

Cognitive-behavioral testing in preclinical models of Alzheimer’s disease has failed to capture deficits in goal-directed action control. Here, we provide the first comprehensive investigation of goal-directed action in a transgenic mouse model of Alzheimer’s disease. Specifically, we tested outcome devaluation performance in male and female human amyloid precursor protein (hAPP)-J20 mice. Mice were first trained to press left and right levers for pellet and sucrose outcomes, respectively (counterbalanced), over 4 d. On test, mice were prefed one of the outcomes to satiety and given a choice between levers. Devaluation performance was intact for 36-week-old wild-types of both sexes, who responded more on the valued relative to the devalued lever (Valued > Devalued). By contrast, devaluation was impaired (Valued = Devalued) for J20 mice of both sexes, and for 52-week-old male mice regardless of genotype. After additional lever press training (i.e., 8-d lever pressing in total), devaluation was intact for all mice, demonstrating that the initial deficits were not a result of a nonspecific impairment in reward processing, depression, or locomotor activity in J20 or aging mice. Follow-up analyses revealed that microglial expression in the dorsal CA1 region of the hippocampus was associated with poorer outcome devaluation performance on initial, but not later tests. Together, these data demonstrate that goal-directed action is initially impaired in J20 mice of both sexes and in aging male mice regardless of genotype, and that this impairment is related to neuroinflammation in the dorsal CA1 hippocampal region.
USP1/UAF1-Stabilized METTL3 Promotes Reactive Astrogliosis and Improves Functional Recovery after Spinal Cord Injury through m6A Modification of YAP1 mRNA
Authors: Ge Xuhui , Ye Wu , Zhu Yufeng , Cui Min , Zhou Jiawen , Xiao Chenyu , Jiang Dongdong , Tang Pengyu , Wang Jiaxing , Wang Zhuanghui , Ji Chengyue , Zhou Xuhui , Cao Xiaojian , Liu Wei , Cai Weihua
Published: January 2023

RNA N6-methyladenosine (m6A) modification is involved in diverse biological processes. However, its role in spinal cord injury (SCI) is poorly understood. The m6A level increases in injured spinal cord, and METTL3, which is the core subunit of methyltransferase complex, is upregulated in reactive astrocytes and further stabilized by the USP1/UAF1 complex after SCI. The USP1/UAF1 complex specifically binds to and subsequently removes K48-linked ubiquitination of the METTL3 protein to maintain its stability after SCI. Moreover, conditional knockout of astrocytic METTL3 in both sexes of mice significantly suppressed reactive astrogliosis after SCI, thus resulting in widespread infiltration of inflammatory cells, aggravated neuronal loss, hampered axonal regeneration, and impaired functional recovery. Mechanistically, theYAP1transcript was identified as a potential target of METTL3 in astrocytes. METTL3 could selectively methylate the 3′-UTR region of theYAP1transcript, which subsequently maintains its stability in an IGF2BP2-dependent manner.In vivo, YAP1 overexpression by adeno-associated virus injection remarkably contributed to reactive astrogliosis and partly reversed the detrimental effects of METTL3 knockout on functional recovery after SCI. Furthermore, we found that the methyltransferase activity of METTL3 plays an essential role in reactive astrogliosis and motor repair, whereas METTL3 mutant without methyltransferase function failed to promote functional recovery after SCI. Our study reveals the previously unreported role of METTL3-mediated m6A modification in SCI and might provide a potential therapy for SCI.

SIGNIFICANCE STATEMENTSpinal cord injury is a devastating trauma of the CNS involving motor and sensory impairments. However, epigenetic modification in spinal cord injury is still unclear. Here, we propose an m6A regulation effect of astrocytic METTL3 following spinal cord injury, and we further characterize its underlying mechanism, which might provide promising strategies for spinal cord injury treatment.
Implementasi Pendekatan Pembelajaran Saintifik pada Pembelajaran PPKn di Kelas X
Authors: Maradila Diah Ayu , Wahono Margi
Published: January 2023

Curriculum 2013 aims to create productive, creative, innovative, affective Indonesian people by strengthening the integration of attitude, skill and knowledge. This curriculum points out scientific approach as the implemented approach in education, especially Civic Education learning. The approach is believed as the best way to develop attitude, skill and knowledge of students.Â  The objective of this study is to find out the implementations, obstacles, and methods to resolve scientific approachâ€™s problem in Civic Education learning Class X in SMA Negeri 1 Kradenan. This study uses qualitative methods. The techniques of collecting data are: observation, interview, and documentation. The validity of study is examined by triangulation technique. The techniques of analyzing data are: reduction, presentation and conclusion. This study shows: (1) the implementations scientific approach in Civic Education learning Class X in SMA Negeri 1 Kradenan which are started from planning, implementation of 6M activities (Observing, Questioning, Experimenting, Associating, Communicating, and Creating ), and scoring. This learning method involves introduction, main activity, and conclusion. (2) the obstacles of implementing scientific approach in Civic Education learning are experienced by Civic Educationâ€™Â  teachers and students. There are some obstacles in every steps of the scientific approach, they are: observing, questioning, collecting information, reasoning, and communicating. (3) teachers implement some methods to overcome obstacles of implementing scientific approach in Civic Education learning. The methods which are implemented in every step are: observing, questioning, collecting information, reasoning, and communicating.
Meningkatkan Hasil Pembelajaran PKn dengan Metode Detektif (Debat Secara Aktif) pada Materi Budaya Demokrasi pada Siswa Kelas XI â€“ IPA1 SMAN 14 Semarang Tahun Pelajaran 2016-2017
Authors: Mulyaningrum Suci
Published: January 2023

Civic of senior high school is not a subject that attract the students. Besides that, there are some reason why studentsâ€™ KKM scores are bellow the other subjectsâ€™ score. At least, students arenâ€™t active during the lesson. Often, a teacher is not putting the highest the effort while using novel educational media and the most important is, the teacher is not courageous enough to apply innovative model of lesson leading. Based on previous experience when the students were passive, teaching civics in Budaya Demokrasi at XI â€“ IPS 1 SMAN 14 Semarang requires a special handling from the teacher.Â Â Â Â  Based on our research, debate method that the ones method at discussion is very important to improve studentsâ€™ academic abilities. The kind of this research which was conducted in two cycles, to enchance their creativity and improve their grade score in civics.The result show that after 2 cycles accompained with teachersâ€™ reflection ther was an increase of proportion of students who passed the average grade in 2 variables, enthusiasm to study and activity during civics lesson. With culivate the descriptif of data for amount of studentsâ€™ who complete increase inÂ  variable 98% and 100%. And the activity during lessons increased to 80% and 100%. The echancement come about studentsâ€™ academic score. The grade score on first cycle and second cycle increased to average score of 79,56% and 84,72%. Percentage of completeness of studentsâ€™ score in particular in first cycle and two is 80% and 100%.With the result, we can conclude that the debate methode can be used to improve the activity and ability of students to understand concept of problem solving education in the civics in class XI â€“ IPS 1 SMAN 14 Semarang.Although intially the students experience is awkward in expressing their opinion on debate method, in the end the student adapted and got achievements based on the good result.
IMPLEMENTASI PENILAIAN RANAH AFEKTIF BERBASIS PEMBELAJARAN KOOPERATIF DI SEKOLAH DASAR
Authors: Adawiah Rabiatul , Darmiyati Darmiyati , Efendi Akhmad Riyan
Published: January 2023

Tujuan penelitian ini adalah untuk meningkatkan hasil belajar ranah afektif siswa dengan menggunakan model Discovery Learning kombinasi Teams Games Tournament dan Examples Non Examples. Penelitian ini menggunakan pendekatan kualitatif dengan metode penelitian tindakan kelas. Penelitan dilakukan terhadap siswa kelas IV semester genap SDN 1 Palam Banjarbaru tahun pelajaran 2020/2021, dengan jumlah siswa 19 orang.  Data dikumpulkan  melalui  teknik observasi. Analisis data dihitung berdasarkan skala persentase dan indikator ketuntasan belajar yang ditetapkan. Hasil penelitian ini menunjukkan bahwa pada siklus pertama hasil penilaian sikap siswa adalah : 26% sangat baik, 42% baik, 16% cukup baik dan 16% perlu bimbingan. Pada siklus kedua, 37% sangat baik, 42% baik, 11,5% cukup baik dan 11,5% perlu bimbingan. Pada siklus ketiga, 42% sangat baik, 47% baik, 11% cukup baik dan tidak ada siswa yang memiliki kriteria sikap yang kurang baik. Pada pertemuan ketiga tidak ditemukan  siswa  yang menunjukkan sikap tidak baik (perlu bimbingan) Dengan demikian dapat dikatakan bahwa penerapan Discovery Learning kombinasi Teams Games Tournament dan Examples Non Examples terbukti dapat meningkatkan hasil belajar ranah kognitif siswa.
Survei Minat Dan Motivasi Guru Ilmu-Ilmu Sosial Studi Lanjut Pada Program Studi Magister Pendidikan Sosiologi FKIP Untan Pontianak
Authors: Dewantara Jagad Aditya , Rustiyarso Rustiyarso , Afandi Afandi
Published: January 2023

This study aims to determine the effect of interest and motivation of social science teachers in junior and senior secondary education units in the city of Pontianak on the choice of further studies to postgraduate study program of sociology master's education FKIP Untan. The research method used was a survey method through a questionnaire assisted by google form which was sent to 254 people as the research sample. The data collection technique is done by indirect communication. The data collection tool used was a questionnaire. The results of the research prove descriptively that the social science teachers in the junior and senior secondary education unit in Pontianak, it turns out that the average percentage for interest is very low where only (25%) and for motivation (47.24%). ) in choosing further studies to postgraduate masters of sociology education FKIP Untan. Interest and motivation factors when analyzed using a two-way ANOVA obtained quantitatively the influence of interest and motivation on the selection of further studies to postgraduate sociology education master's degree was only 38,% and the rest was influenced by other factors, 62%.
Rekruitmen Partai Politik Dalam Pembentukan Dinasti Ratu Atut Chosiyah di Provinsi Banten
Authors: Hafsari Iqbal , Andriyani Lusi , Setiawan Asep
Published: January 2023

Kajian ini akan menarsikan tentang partai politik, rekrutmen partai dalam proses pembentukan dinasti politik di Banten. Penelitian ini bertujuan untuk melihat bagaimana partai politik dalam proses rekrutmen politik tersebut memperkuat terjadinya proses pembentukan dinasti politik di Provinsi Banten dimulai dari Tubagus Chasan Shohib (Ayah Kandung Ratu Atut/Tokoh Kuat Lokal) yang menjadikan Ratu Atut Chosiyah sebagai Wakil Gubernur Banten 2001 dan Gubernur Banten 2007-2017. Dinasti politik keluarga Ratu Atut yang menguasai demokrasi lokal dengan mendistribusikan lingkaran keluarga ke dalam ruang kekuasaan lokal melalui jalur mekanisme prosedural formal yaitu Pemilihan Umum (Pemilu) dan Pemilihan Kepala Daerah (Pilkada) sehingga politik lokal didominasi oleh politik kekeluargaan atau kekerabatan yang mengakar dan kokoh. Metode penelitian yang digunakan ialah kualitatif deskriptif dengan teknik pengumpulan data sekunder publikasi ilmiah baik jurnal, artikel ilmiah, dan media  mainstream yang dipilih secara ketat. Hasil penelitian menunjukkan bahwa belum ada satupun tokoh partai lokal yang mampu mengalahkan pengaruh hegemoni kekuasaan dinasti Ratu Atut dalam setiap pertarungan konstelasi politik di Banten. Dinasti sangat menguasai basis/peta politik yang didukung sumber ekonomi, sosial, politik yang kuat. Oleh sebab itu, partai politik  memiliki kecenderungan tidak berdaya dan pragmatis dalam rekrutmen kepala daerah.Kajian ini akan menarsikan tentang partai politik, rekrutmen partai dalam proses pembentukan dinasti politik di Banten. Penelitian ini bertujuan untuk melihat bagaimana partai politik dalam proses rekrutmen politik tersebut memperkuat terjadinya proses pembentukan dinasti politik di Provinsi Banten dimulai dari Tubagus Chasan Shohib (Ayah Kandung Ratu Atut/Tokoh Kuat Lokal) yang menjadikan Ratu Atut Chosiyah sebagai Wakil Gubernur Banten 2001 dan Gubernur Banten 2007-2017. Dinasti politik keluarga Ratu Atut yang menguasai demokrasi lokal dengan mendistribusikan lingkaran keluarga ke dalam ruang kekuasaan lokal melalui jalur mekanisme prosedural formal yaitu Pemilihan Umum (Pemilu) dan Pemilihan Kepala Daerah (Pilkada) sehingga politik lokal didominasi oleh politik kekeluargaan atau kekerabatan yang mengakar dan kokoh. Metode penelitian yang digunakan ialah kualitatif deskriptif dengan teknik pengumpulan data sekunder publikasi ilmiah baik jurnal, artikel ilmiah, dan media  mainstream yang dipilih secara ketat. Hasil penelitian menunjukkan bahwa belum ada satupun tokoh partai lokal yang mampu mengalahkan pengaruh hegemoni kekuasaan dinasti Ratu Atut dalam setiap pertarungan konstelasi politik di Banten. Dinasti sangat menguasai basis/peta politik yang didukung sumber ekonomi, sosial, politik yang kuat. Oleh sebab itu, partai politik  memiliki kecenderungan tidak berdaya dan pragmatis dalam rekrutmen kepala daerah.
Aspek Positif Terhadap Intensi Mengurangi Sampah Plastik
Authors: Kamulyan Inten Lanjar , Dahriyanto Luthfi Fathan
Published: January 2023

Sampah plastik menjadi masalah yang cukup menyita perhatian publik beberapa tahun terakhir. Menurut KLHK dan Kementrian Perindustrian (2016), jumlah timbunan sampah di Indonesia sudah mencapai 65,2 juta ton pertahun. Berbagai cara untuk mengurangi volume sampah plastik dikerahkan untuk dapat memprediksi dan meningkatkan kesadaran lingkungan salah satunya dengan mengukur intensi mengurangi sampah plastik. Oleh karena itu penelitian ini bertujuan untuk mengetahui adanya pengaruh afek positif terhadap intensi mengurangi sampah plastik pada mahasiswa Universitas Negeri Semarang. Penelitian menggunakan pendekatan kuantitatif dengan desain eksperimen murni randomized pretest-posttest control group design. Subjek dalam penelitian berjumlah 60 mahasiswa Universitas Negeri Semarang yang dibagi ke dalam kelompok eksperimen (30 orang) dan kelompok kontrol (30 orang). Validasi modul perlakuan penelitian ini menggunakan validitas isi yang diperoleh menggunakan teknik Aiken's V. Hasil validitas isi menunjukkan kisaran antara 0,5 hingga 0,875 yang berarti modul perlakuan memiliki validitas isi yang berkisar antara kategori sedang hingga tinggi. Data penelitian diambil menggunakan dua skala, yaitu skala intensi mengurangi sampah plastik yang terdiri atas 31 aitem (sig 0,936) dan skala afek positif yang terdiri atas 28 aitem (sig. 0,932). Metode analisis yang digunakan yaitu Analysis of Variance (ANOVA). Berdasarkan hasil analisis data, diperoleh nilai signifikansi sebesar 0,048. Dengan demikian hipotesis penelitian diterima yaitu ada pengaruh antara afek positif dengan intensi mengurangi sampah plastik pada mahasiswa Universitas Negeri Semarang.
Nilai Budaya Kolektivisme dan Perilaku Asertif pada Suku Jawa
Authors: Zakiya Nufailatun , Hariyadi Sugeng
Published: January 2023

Nilai budaya kolektivisme membentuk konstruk diri interdependen yang khas dengan hubungan saling bergantung dan memprioritaskan kelompok dari pada kebutuhan individual. Sering kali demi mempertahankan keharmonisan hubungan dengan orang lain membuat masyarakat Jawa sukar berperilaku asertif karena dikhawatirkan akan menyinggung perasaan orang lain. Hipotesis yang diajukan dalam penelitian ini adalah “Terdapat hubungan negatif antara nilai budaya kolektivisme dengan perilaku asertif pada suku Jawa di Desa Pesanggrahan”. Jenis penelitian ini yaitu kuantitatif dengan metode korelasional. Populasi dalam penelitian ini merupakan warga Desa Pesanggrahan, dimana desa ini dinilai masih memegang erat nilai kolektivisme. Adapun teknik sampling yang digunakan yakni two stage cluster random sampling. Metode pengumpulan data dilakukan menggunakan skala psikologi, yakni skala perilaku asertif dan skala nilai budaya kolektivisme yang telah dinyatakan valid. Hasil uji reliabilitas skala perilaku asertif sebesar 0,772 (kuat) sedangkan hasil uji reliabilitas nilai budaya kolektivisme sebesar 0,905 (sangat kuat). Data dianalisis menggunakan teknik korelasi Product Moment. Berdasarkan uji hipotesis diperoleh nilai korelasi Pearson sebesar -0,543 dengan signifikansi 0,000, maka dapat disimpulkan bahwa hipotesis penelitian diterima.
Determination of Inhibition Effect of Propolis Extract on Watermelon mosaic virus in Edible Seed Squash
Authors: Yeşil Serkan
Published: January 2023

Edible seed squash (Cucurbita pepo L, ESS), which is grown for its seeds to consume as a snack, has a very important place in vegetable production in Türkiye. Viruses are one of the most problems in the cultivation of ESS in the country. One of these diseases is Watermelon mosaic virus (WMV, Potyvirus, Potyviridae). Also, it’s very common and devastating on other cucurbits worldwide. Propolis, which is composed mainly by the plant resins and exudates that honey bees gather, showed antiviral activity against plant and human viruses. In this study, the potential of propolis to control WMV was investigated by taking advantage of these antimicrobial properties of propolis. For this purpose, propolis extracted with 95% ethanol and diluted in distilled water to obtain different concentrations as 2, 4, 6, 8 and 10% were used. Effects of propolis against WMV were determined by in vitro and in vivo studies. Except of 2, and 4%, all concentrations caused to symptoms reductions of the infection, in all studies. In the result of in vitro studies, the ratios of healthy plants were calculated as 10, 20, 40% and 20, 30, 50% after one and two hours, respectively. In vivo, by spraying concentrations of 6, 8 and 10% before inoculation obtained healthy plants as 20, 40 and 60% after one-hour period, and as 20, 30 and 50% after two-hour period, while the extracts sprayed after inoculation, ratios of healthy plants as 10, 20 and 30% after one-hour period, and as 10, 20 and 20% after two-hour period. According to the results of the study, it was determined that applications of different propolis concentrations had the potential to reduce WMV infection, and these results should be supported by field trials.