bluuebunny/crossref_metadata_2025 huggingface dataset:
Scale Formation and Degradation of Diffusion Coatings Deposited on 9% Cr Steel in Molten Solar Salt
Authors: Oskay Ceyhun , Meißner Tobias M. , Dobler Carmen , Grégoire Benjamin , Galetz Mathias C.
Published: October 2019

The employment of ferritic-martensitic steels e.g., P91, as structural materials in concentrated solar power (CSP) plants can significantly increase cost-efficiency. However, their application is strongly restricted by their lower corrosion resistance in molten nitrates, compared to austenitic steels or Ni-based alloys. In this study, Cr-, Al-, and Cr/Al-diffusion coatings were deposited on P91 via pack cementation in order to improve its scaling behavior in molten solar salt (MSS). The corrosion behavior of coated specimens was investigated with respect to uncoated P91 in MSS at 600 °C for up to 1000 h. The exposure in MSS resulted in a thick, highly porous, and multi-layered oxide scale on uncoated P91 consisting of hematite, magnetite, and sodium ferrite. On the other hand, the scale grown on the chromized P91 comprised of a thin Cr-rich inner layer, which shifted breakaway to prolonged exposure durations. The aluminized specimens both formed very thin, highly protective alumina scales with localized protrusions.
Effect of Heat Treatment on the Cavitation Erosion Performance of WC–12Co Coatings
Authors: Du Jin , Zhang Jianfeng , Zhang Chao
Published: October 2019

WC–12Co coatings were deposited on 16Cr5Ni stainless steel substrate by high-velocity oxygen fuel (HVOF) process, followed by a one-hour heat-treatment in a tube furnace with a nitrogen atmosphere at 650, 800, 950, and 1100 °C, respectively. The influence of heat-treatment temperature on properties and cavitation erosion resistance of as-sprayed and heat-treated WC–12Co coatings was studied. The cavitation erosion test was carried out with ultrasonic cavitation erosion equipment. The porosity, microhardness, phase composition, as well as surface and cross-section morphology of the coatings were characterized. The coating heat-treated at 800 °C showed three typical cavitation erosion stages and exhibited the best cavitation erosion resistance. The cavitation erosion resistance was closely related to the coating microstructure and heat-treatment process. 3D optical microscopy was used to analyze the eroded surface of the coatings. The cavitation erosion mechanism of the coatings was discussed.
Glycan Analysis as Biomarkers for Testicular Cancer
Authors: Hires Michal , Jane Eduard , Mego Michal , Chovanec Michal , Kasak Peter , Tkac Jan
Published: October 2019

The U.S. Preventive Services Task Force does not recommend routine screening for testicular cancer (TC) in asymptomatic men, essentially because serological testicular cancer (TC) biomarkers are not reliable. The main reason is that two of the most important TC biomarkers, α-fetoprotein (AFP) and human chorionic gonadotropin (hCG), are not produced solely due to TC. Moreover, up to 40% of patients with TC do not have elevated serological biomarkers, which is why serial imaging with CT is the chief means of monitoring progress. On the other hand, exposure to radiation can lead to an increased risk of secondary malignancies. This review provides the first comprehensive account of the applicability of protein glycoprofiling as a promising biomarker for TC with applications in disease diagnostics, monitoring and recurrence evaluation. The review first deals with the description and classification of TC. Secondly, the limitations of current TC biomarkers such as hCG, AFP and lactate dehydrogenase are provided together with an extensive overview of the glycosylation of hCG and AFP related to TC. The final part of the review summarises the potential of glycan changes on either hCG and AFP as TC biomarkers for diagnostics and prognostics purposes, and for disease recurrence evaluation. Finally, an analysis of glycans in serum and tissues as TC biomarkers is also provided.
Sodium Batteries: A Review on Sodium-Sulfur and Sodium-Air Batteries
Authors: Chawla Neha , Safa Meer
Published: October 2019

Lithium-ion batteries are currently used for various applications since they are lightweight, stable, and flexible. With the increased demand for portable electronics and electric vehicles, it has become necessary to develop newer, smaller, and lighter batteries with increased cycle life, high energy density, and overall better battery performance. Since the sources of lithium are limited and also because of the high cost of the metal, it is necessary to find alternatives. Sodium batteries have shown great potential, and hence several researchers are working on improving the battery performance of the various sodium batteries. This paper is a brief review of the current research in sodium-sulfur and sodium-air batteries.
The Effect of Insect Defoliations and Seed Production on the Dynamics of Radial Growth Synchrony among Scots Pine Pinus sylvestris L. Provenances
Authors: Klisz Marcin , Puchałka Radosław , Wilczyński Sławomir , Kantorowicz Władysław , Jabłoński Tomasz , Kowalczyk Jan
Published: October 2019

The intraspecific variation of climate–growth relationships observed on provenance trials results from among–provenance differences in phenotypic plasticity. Temporal variation in radial growth synchrony among provenances may be modified by adverse climatic/biotic conditions such as drought or insect defoliation. However, these factors can potentially diminish provenance–specific growth reactions and, consequently, prevent the identification of provenances with the highest adaptive potential. Thus, understanding the influence of major biotic conditions on provenance–specific climate–growth relationships seems to be important to anticipate climate change. To determine provenance–specific growth patterns in relation to climate conditions (drought), seed production (reproductive effort), and insect defoliation in a common garden of Scots pine (Pinus sylvestris L.), we applied dendroecological techniques to time–series of tree–ring widths and basal area increments. The long–term records of seed production and insect outbreaks from the local Scots pine stands were used to explain the potential effect of biotic factors on the temporal dynamics of radial growth synchrony. During a period of favorable growth conditions, Scots pine provenances showed a decline in inter–provenance synchronicity in growth patterns, while during years affected by severe soil water deficit and insect defoliation, they manifested high uniformity in growth dynamics. The long–term trend in growth synchrony among P. sylvestris provenances depend on both abiotic and biotic environmental factors. This gains significance following an introduction of the appropriate selection of tree provenances for climate–smart forestry.
Simulation-Based Performance Validation of Homomorphic Encryption Algorithms in the Internet of Things
Authors: Kölsch Johannes , Heinz Christopher , Ratzke Axel , Grimm Christoph
Published: October 2019

IoT systems consist of Hardware/Software systems (e.g., sensors) that are embedded in a physical world, networked and that interact with complex software platforms. The validation of such systems is a challenge and currently mostly done by prototypes. This paper presents the virtual environment for simulation, emulation and validation of an IoT platform and its semantic model in real life scenarios. It is based on a decentralized, bottom up approach that offers interoperability of IoT devices and the value-added services they want to use across different domains. The framework is demonstrated by a comprehensive case study. The example consists of the complete IoT “Smart Energy” use case with focus on data privacy by homomorphic encryption. The performance of the network is compared while using partially homomorphic encryption, fully homomorphic encryption and no encryption at all.As a major result, we found that our framework is capable of simulating big IoT networks and the overhead introduced by homomorphic encryption is feasible for VICINITY.
A Method for the Structure-Based, Genome-Wide Analysis of Bacterial Intergenic Sequences Identifies Shared Compositional and Functional Features
Authors: Lenzini Leonardo , Di Patti Francesca , Livi Roberto , Fondi Marco , Fani Renato , Mengoni Alessio
Published: October 2019

In this paper, we propose a computational strategy for performing genome-wide analyses of intergenic sequences in bacterial genomes. Following similar directions of a previous paper, where a method for genome-wide analysis of eucaryotic Intergenic sequences was proposed, here we developed a tool for implementing similar concepts in bacteria genomes. This allows us to (i) classify intergenic sequences into clusters, characterized by specific global structural features and (ii) draw possible relations with their functional features.
Development of a Landslide Early Warning System in Indonesia
Authors: Hidayat Rokhmat , Sutanto Samuel Jonson , Hidayah Alidina , Ridwan Banata , Mulyana Arif
Published: October 2019

Landslides are one of the most disastrous natural hazards in Indonesia, in terms of number of fatalities and economic losses. Therefore, Balai Litbang Sabo (BLS) has developed a Landslide Early Warning System (LEWS) for Indonesia, based on a Delft–FEWS (Flood Early Warning System) platform. This system utilizes daily precipitation data, a rainfall threshold method, and a Transient Rainfall Infiltration and Grid-based Regional Slope-stability model (TRIGRS) to predict landslide occurrences. For precipitation data, we use a combination of 1-day and 3-day cumulative observed and forecasted precipitation data, obtained from the Tropical Rainfall Measuring Mission (TRMM) and the Indonesian Meteorological Climatological and Geophysical Agency (BMKG). The TRIGRS model is used to simulate the slope stability in regions that are predicted to have a high probability of landslide occurrence. Our results show that the landslides, which occurred in Pacitan (28 November 2017) and Brebes regions (22 February 2018), could be detected by the LEWS from one to three days in advance. The TRIGRS model supports the warning signals issued by the LEWS, with a simulated factor of safety values lower than 1 in these locations. The ability of the Indonesian LEWS to detect landslide occurrences in Pacitan and Brebes indicates that the LEWS shows good potential to detect landslide occurrences a few days in advance. However, this system is still undergoing further developments for better landslide prediction.
Gwendolyn Brooks and the Legacies of Architectural Modernity
Authors: Gill Jo
Published: October 2019

This essay reads the work of poet, Gwendolyn Brooks, in terms of its critical engagement with the architectural modernity of her home city, Chicago. Taking her poetry from A Street in Bronzeville (1945) through to the 1968 collection, In the Mecca, as a primary focus, the essay traces the significance of Chicago style architecture on Brooks’ aesthetic. It was in Chicago that some of the first tall office buildings were designed; it was here that structural steel and glass were first used to distinctive architectural effect, and it was here, in 1893, that the World’s Columbian Exposition was held—an event that, for better or worse, was to shape American architecture well into the twentieth century. Brooks’ poetry is alert to this history, attuned to contemporary debates about urban design and sensitive to architectural experience and affect. This context informs and shapes her work in often unexpected ways. Her approach is often oblique (registered in metaphor, style, and voice) but nevertheless incisive in its rendering of the relationship between architecture, modernity and power.
FracL: A Tool for Characterizing the Fractality of Landscape Gradients from a New Perspective
Authors: Gao Peichao , Cushman Samuel A. , Liu Gang , Ye Sijing , Shen Shi , Cheng Changxiu
Published: October 2019

The past several years have witnessed much progress in landscape ecology and fractal analysis. In landscape ecology, the gradient model of landscape patterns (i.e., landscape gradient) has emerged as a new operating paradigm, where most landscape metrics do not apply because they were developed for the patch mosaic model. In the fractal analysis, a new definition of fractal has been proposed, and various new fractal metrics have been developed. This technical note aims to provide an intersection of these two lines of advance, which will further present an opportunity to advance geo-informatics by considering the latest progress in both landscape ecology and fractal analysis. We first present an overview of the new definition of fractal and all the fractal metrics developed under this new definition. Since the chief obstacle to geographers and landscape ecologists in applying these metrics is the lack of readily accessible methods for their easy computation, we then develop an integrated tool to compute them on landscape gradients. The developed tool facilitates the computation of these new fractal metrics. A case study was carried out with real-life landscape gradients, namely a digital terrain model. These new fractal metrics and the developed tool can be expected to facilitate the fractal characterization of the patterns of gradient landscapes and the understanding of landscape dynamics from a new perspective.
Paper-Based Flexible Electrode Using Chemically-Modified Graphene and Functionalized Multiwalled Carbon Nanotube Composites for Electrophysiological Signal Sensing
Authors: Hossain Md Faruk , Heo Jae Sang , Nelson John , Kim Insoo
Published: October 2019

Flexible paper-based physiological sensor electrodes were developed using chemically-modified graphene (CG) and carboxylic-functionalized multiwalled carbon nanotube composites (f@MWCNTs). A solvothermal process with additional treatment was conducted to synthesize CG and f@MWCNTs to make CG-f@MWCNT composites. The composite was sonicated in an appropriate solvent to make a uniform suspension, and then it was drop cast on a nylon membrane in a vacuum filter. A number of batches (0%~35% f@MWCNTs) were prepared to investigate the performance of the physical characteristics. The 25% f@MWCNT-loaded composite showed the best adhesion on the paper substrate. The surface topography and chemical bonding of the proposed CG-f@MWCNT electrodes were characterized by scanning electron microscopy (SEM) and Raman spectroscopy, respectively. The average sheet resistance of the 25% CG-f@MWCNT electrode was determined to be 75 Ω/□, and it showed a skin contact impedance of 45.12 kΩ at 100 Hz. Electrocardiogram (ECG) signals were recorded from the chest and fingertips of healthy adults using the proposed electrodes. The CG-f@MWCNT electrodes demonstrated comfortability and a high sensitivity for electrocardiogram signal detection.
AndroShield: Automated Android Applications Vulnerability Detection, a Hybrid Static and Dynamic Analysis Approach
Authors: Amin Amr , Eldessouki Amgad , Magdy Menna Tullah , Abdeen Nouran , Hindy Hanan , Hegazy Islam
Published: October 2019

The security of mobile applications has become a major research field which is associated with a lot of challenges. The high rate of developing mobile applications has resulted in less secure applications. This is due to what is called the “rush to release” as defined by Ponemon Institute. Security testing—which is considered one of the main phases of the development life cycle—is either not performed or given minimal time; hence, there is a need for security testing automation. One of the techniques used is Automated Vulnerability Detection. Vulnerability detection is one of the security tests that aims at pinpointing potential security leaks. Fixing those leaks results in protecting smart-phones and tablet mobile device users against attacks. This paper focuses on building a hybrid approach of static and dynamic analysis for detecting the vulnerabilities of Android applications. This approach is capsuled in a usable platform (web application) to make it easy to use for both public users and professional developers. Static analysis, on one hand, performs code analysis. It does not require running the application to detect vulnerabilities. Dynamic analysis, on the other hand, detects the vulnerabilities that are dependent on the run-time behaviour of the application and cannot be detected using static analysis. The model is evaluated against different applications with different security vulnerabilities. Compared with other detection platforms, our model detects information leaks as well as insecure network requests alongside other commonly detected flaws that harm users’ privacy. The code is available through a GitHub repository for public contribution.
Oral–Gut Microbiota and Arthritis: Is There an Evidence-Based Axis?
Authors: Drago Lorenzo , Zuccotti Gian Vincenzo , Romanò Carlo Luca , Goswami Karan , Villafañe Jorge Hugo , Mattina Roberto , Parvizi Javad
Published: October 2019

The gut microbiome appears to be a significant contributor to musculoskeletal health and disease. Recently, it has been found that oral microbiota are involved in arthritis pathogenesis. Microbiome composition and its functional implications have been associated with the prevention of bone loss and/or reducing fracture risk. The link between gut–oral microbiota and joint inflammation in animal models of arthritis has been established, and it is now receiving increasing attention in human studies. Recent papers have demonstrated substantial alterations in the gut and oral microbiota in patients with rheumatoid arthritis (RA) and osteoarthritis (OA). These alterations resemble those established in systemic inflammatory conditions (inflammatory bowel disease, spondyloarthritides, and psoriasis), which include decreased microbial diversity and a disturbance of immunoregulatory properties. An association between abundance of oral Porphyromonas gingivalis and intestinal Prevotella copri in RA patients compared to healthy controls has been clearly demonstrated. These new findings open important future horizons both for understanding disease pathophysiology and for developing novel biomarkers and treatment strategies. The changes and decreased diversity of oral and gut microbiota seem to play an important role in the etiopathogenesis of RA and OA. However, specific microbial clusters and biomarkers belonging to oral and gut microbiota need to be further investigated to highlight the mechanisms related to alterations in bones and joints inflammatory pathway.
Obstructive Sleep Apnea: Emerging Treatments Targeting the Genioglossus Muscle
Authors: Mediano Olga , Romero-Peralta Sofia , Resano Pilar , Cano-Pumarega Irene , Sánchez-de-la-Torre Manuel , Castillo-García María , Martínez-Sánchez Ana Belén , Ortigado Ana , García-Río Francisco
Published: October 2019

Obstructive sleep apnea (OSA) is characterized by repetitive episodes of upper airway obstruction caused by a loss of upper airway dilator muscle tone during sleep and an inadequate compensatory response by these muscles in the context of an anatomically compromised airway. The genioglossus (GG) is the main upper airway dilator muscle. Currently, continuous positive airway pressure is the first-line treatment for OSA. Nevertheless, problems related to poor adherence have been described in some groups of patients. In recent years, new OSA treatment strategies have been developed to improve GG function. (A) Hypoglossal nerve electrical stimulation leads to significant improvements in objective (apnea-hypopnea index, or AHI) and subjective measurements of OSA severity, but its invasive nature limits its application. (B) A recently introduced combination of drugs administered orally before bedtime reduces AHI and improves the responsiveness of the GG. (C) Finally, myofunctional therapy also decreases AHI, and it might be considered in combination with other treatments. Our objective is to review these therapies in order to advance current understanding of the prospects for alternative OSA treatments.
Nosocomial Vs. Community-Acquired Infective Endocarditis in Spain: Location, Trends, Clinical Presentation, Etiology, and Survival in the 21st Century
Authors: Ortega-Loubon Christian , Muñoz-Moreno María Fe , García Irene Andrés , Álvarez Francisco Javier , Gómez-Sánchez Esther , Bustamante-Munguira Juan , Lorenzo-López Mario , Tamayo-Velasco Álvaro , Jorge-Monjas Pablo , Resino Salvador , Tamayo Eduardo , Heredia-Rodríguez María
Published: October 2019

Major changes have occurred in the epidemiology and etiology of infective endocarditis (IE). Nevertheless, the differences between nosocomial infective endocarditis (NIE) and community-acquired infective endocarditis (CIE) have not been addressed in a population-based study. We conducted a retrospective, nationwide, temporal trend study from 1997 to 2014 analyzing the epidemiology, clinical, geographical, meteorological characteristics of patients diagnosed with IE in Spain, to distinguish NIE from CIE. Among 25,952 patients with IE (62.2 ± 18·6 years; 65.9% men), 45.9% had NIE. The incidence of IE increased from 2.83 to 3.73 due to the NIE incidence increment with a decline in CIE. Patients with NIE were older (63.8 years vs. 60.8 years, p < 0·001), presented a higher Charlson index (1.22 vs. 1.03, p < 0.001), a greater history of implanted cardiac devices (8.7% vs. 4.6%, p < 0.001), and higher mortality (31.5% vs. 21.7%, p < 0.001). The most frequent microorganism for both NIE and CIE was Staphylococcus (p < 0.001), and the North reported a higher incidence (p < 0.001). Risk factors of mortality for NIE were age, Charlson index, hemodialysis, shock, heart failure, and stroke. Risk factors for CIE included female sex, renal disease, and cardiac-device carriers. The etiology of IE shifted from community origins to mostly nosocomial-associated infections. Higher morbidity, mortality, and poorer outcomes are associated with NIE.
Comparison of Hemodynamic Factors Predicting Prognosis in Heart Failure: A Systematic Review
Authors: Aalders Margot , Kok Wouter
Published: October 2019

Objectives: We systematically reviewed the literature to address the question of which of the three hemodynamic factors predicts prognosis best in heart failure patients when directly compared to each other: cardiac output, preload or afterload. Methods: Prognostic studies in heart failure (HF) were searched that included at least two of the three hemodynamic variables: (1) cardiac output or cardiac index (CI), (2) preload represented by pulmonary capillary wedge pressure (PCWP) and (3) afterload simplified to systolic blood pressure (SBP). Critical appraisal was done according to the QUIPS format for prognostic studies. The main endpoint was all-cause mortality, which could be combined with other endpoints. We report the number of studies in which CI, PCWP and SBP remained significant prognostic predictors in multivariate analysis. We also assessed whether hemodynamic predictors of prognosis varied in four different HF-populations. Results: Included were 18 studies containing a multivariate analysis. PCWP was an independent predictor of prognosis in 10 of 18 studies, SBP in 3 of 14 studies and CI in none of 18 studies. Results were not specific for any of the HF-populations. Conclusions: A higher PCWP and lower SBP are independent predictors of poor prognosis in HF. In spite of the frequently used concept behind HF, this review demonstrates that CI is not an independent predictor of prognosis in HF.
Protected Groups in Refugee Law and International Law
Authors: Rikhof Joseph , Geerts Ashley
Published: October 2019

The 1951 Convention Relating to the Status of Refugees (“Refugee Convention”) defines ‘persecution’ based on five enumerated grounds: race, religion, nationality, membership of a particular social group, and political opinion. This list of protected groups has not changed in the nearly 70 years since its inception, although the political and social context that gave rise to the Refugee Convention has changed. This article examines how ‘membership in a particular social group’ (“MPSG”) has been interpreted, then surveys international human rights law, transnational criminal law, international humanitarian law, and international criminal law instruments to determine whether MPSG can encompass the broader protections afforded under other international law regimes. It concludes that the enumerated grounds are largely consistent with other instruments and protects, or at least has the potential to protect, many of the other categories through MPSG. However, as this ground is subject to domestic judicial interpretation and various analytical approaches taken in different countries, protection could be enhanced by amending the Refugee Convention to explicitly include additional protected groups from these other areas of international law, specifically international human rights law and international criminal law.
Synthesis of 2-Cyanopyrimidines
Authors: Kalogirou Andreas S. , Koutentis Panayiotis A.
Published: October 2019

4,6-Dichloro-2-(methylthio)pyrimidine (7) was converted to 4-chloro-6-methoxy-2-(methylthio)pyrimidine (15) and 4,6-dimethoxy-2-(methylthio)pyrimidine (14). Chlorination of the latter with N-chlorosuccinimide (NCS) affords 5-chloro-4,6-dimethoxy-2-(methylthio)pyrimidine (16) in 56% yield. Both methylthiopyrimidines 15 and 14 were converted in two steps to 4-chloro-6-methoxypyrimidine-2-carbonitrile (13) and 4,6-dimethoxypyrimidine-2-carbonitrile (12), respectively, after oxidation to sulfones and displacement of the sulfinate group with KCN. 4,6-Dimethoxypyrimidine-2-carbonitrile (12) was chlorinated with NCS to give 5-chloro-4,6-dimethoxypyrimidine-2-carbonitrile (10) in 53% yield. All new compounds were fully characterized.
Left Ventricular Morphology and Function as a Determinant of Pulmonary Hypertension in Patients with Severe Aortic Stenosis: Cardiovascular Magnetic Resonance Imaging Study
Authors: Gumauskiene Birute , Padervinskiene Lina , Vaskelyte Jolanta Justina , Vaitiekiene Audrone , Lapinskas Tomas , Hoppenot Deimante , Miliauskas Skaidrius , Galnaitiene Gryte , Simkus Paulius , Ereminiene Egle
Published: October 2019

Background and Objectives: The influence of cardiac magnetic resonance (CMR) derived left ventricular (LV) parameters on the prognosis of patients with aortic stenosis (AS) was analyzed in several studies. However, the data on the relations between the LV parameters and the development of pulmonary hypertension (PH) in severe AS is lacking. Our objectives were to evaluate the CMR-derived changes of the LV size, morphology, and function in patients with isolated severe AS and PH, and to investigate the prognostic impact of these parameters on elevated systolic pulmonary artery pressure (sPAP). Materials and Methods: Thirty patients with isolated severe AS (aortic valve area ≤1 cm2) underwent a 2D-echocardiography (2D echo) and CMR before aortic valve replacement. Indices of the LV mass and volumes and ejection fraction were analyzed by CMR. The LV global longitudinal (LV LGS) and circumferential strain (LV CS) were calculated using CMR feature tracking (CMR-FT) software (Medis Suite QStrain 2.0, Medis Medical Imaging Systems B.V., Leiden, The Netherlands). The LV fibrosis expansion was assessed using a late gadolinium enhancement sequence. PH was defined as having an estimated sPAP of ≥45 mm Hg. The statistical analysis as performed using SPSS version 23.0 (SPSS, Chicago, IL, USA) Results: 30 patients with severe AS were included in the study, 23% with severe isolated AS had PH (mean sPAP 55 ± 6.6 mm Hg). More severe LV anatomical and functional abnormalities were observed in patients with PH when compared with patients without PH—a higher LV end-diastolic volume index (EDVi) (140 [120.0–160.0] vs. 90.0 mL/m² [82.5–103.0], p = 0.04), larger LV fibrosis area (7.8 [5.6–8.0] vs. 1.3% [1.2–1.5], p = 0.005), as well as lower LV global longitudinal strain (GLS; −14.0 [−14.9–(−8.9)] vs. −21.1% [−23.4–(−17.8)], p = 0.004). By receiver–operating characteristic (ROC) curve analysis, LV EDVi > 107.7 mL/m² (Area Under the Curve (AUC) 95.7%), LV GLS < −15.5% (AUC 86.3%), and LV fibrosis area >5% (AUC 89.3) were found to be robust predictors of PH in severe AS patients. Conclusions: In patients with severe aortic stenosis, a larger end-diastolic LV volume, impaired LV global longitudinal strain, and larger LV fibrosis extent can predict the development of pulmonary hypertension.
Fundamental Mechanisms for Irradiation-Hardening and Embrittlement: A Review
Authors: Xiao Xiazi
Published: October 2019

It has long been recognized that exposure to irradiation environments could dramatically degrade the mechanical properties of nuclear structural materials, i.e., irradiation-hardening and embrittlement. With the development of numerical simulation capability and advanced experimental equipment, the mysterious veil covering the fundamental mechanisms of irradiation-hardening and embrittlement has been gradually unveiled in recent years. This review intends to offer an overview of the fundamental mechanisms in this field at moderate irradiation conditions. After a general introduction of the phenomena of irradiation-hardening and embrittlement, the formation of irradiation-induced defects is discussed, covering the influence of both irradiation conditions and material properties. Then, the dislocation-defect interaction is addressed, which summarizes the interaction process and strength for various defect types and testing conditions. Moreover, the evolution mechanisms of defects and dislocations are focused on, involving the annihilation of irradiation defects, formation of defect-free channels, and generation of microvoids and cracks. Finally, this review closes with the current comprehension of irradiation-hardening and embrittlement, and aims to help design next-generation irradiation-resistant materials.
Multi-Analytical Characterization of Slags to Determine the Chromium Concentration for a Possible Re-Extraction
Authors: Horckmans Liesbeth , Möckel Robert , Nielsen Peter , Kukurugya Frantisek , Vanhoof Christine , Morillon Agnieszka , Algermissen David
Published: October 2019

The CHROMIC project (effiCient mineral processing and Hydrometallurgical RecOvery of by-product Metals from low-grade metal contaIning seCondary raw materials) aims to recover chromium from steelmaking and ferrochrome slags to regain valuable resources and simultaneously reduce potential environmental impacts. To develop the recovery flowsheets and reliably calculate metal recovery, an accurate assessment of chromium concentration and distribution is essential. Therefore, model streams were thoroughly characterized using a combination of analytical techniques. In all materials, chromium is present in distinct but often small spinel phases, intergrown with other minerals and showing a considerable zonation in Cr content with higher amounts in the cores. The small size of the Cr-rich particles makes recovery by mineral processing challenging. Measured chromium content was found to differ largely based on the chemical dissolution method applied. The analysis of insoluble residues and comparison with a standard reference material evidenced that standard acid dissolution procedures based on HCl/HNO3/HBF4 and HNO3/HF/H2O2 are insufficient to fully dissolve spinel structures, leading to severe underestimations of chromium content. A sodium peroxide treatment is required for a full dissolution of spinels. This is noteworthy, since most of the legislation for the reuse of slags is currently based on acid dissolution methods.
Bioactivities of Centaurium erythraea (Gentianaceae) Decoctions: Antioxidant Activity, Enzyme Inhibition and Docking Studies
Authors: Guedes Laura , Reis Pedro B. P. S. , Machuqueiro Miguel , Ressaissi Asma , Pacheco Rita , Serralheiro Maria Luísa
Published: October 2019

Centaurium erythraea is recommended for the treatment of gastrointestinal disorders and to reduce hypercholesterolemia in ethno-medicinal practice. To perform a top-down study that could give some insight into the molecular basis of these bioactivities, decoctions from C. erythraea leaves were prepared and the compounds were identified by liquid chromatography-high resolution tandem mass spectrometry (LC–MS/MS). Secoiridoids glycosides, like gentiopicroside and sweroside, and several xanthones, such as di-hydroxy-dimethoxyxanthone, were identified. Following some of the bioactivities previously ascribed to C. erythraea, we have studied its antioxidant capacity and the ability to inhibit acetylcholinesterase (AChE) and 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR). Significant antioxidant activities were observed, following three assays: free radical 2,2-diphenyl-1-picrylhydrazyl (DPPH) reduction; lipoperoxidation; and NO radical scavenging capacity. The AChE and HMGR inhibitory activities for the decoction were also measured (56% at 500 μg/mL and 48% at 10 μg/mL, respectively). Molecular docking studies indicated that xanthones are better AChE inhibitors than gentiopicroside, while this compound exhibits a better shape complementarity with the HMGR active site than xanthones. To the extent of our knowledge, this is the first report on AChE and HMGR activities by C. erythraea decoctions, in a top-down analysis, complemented with in silico molecular docking, which aims to understand, at the molecular level, some of the biological effects ascribed to infusions from this plant.
A Chemosensory GPCR as a Potential Target to Control the Root-Knot Nematode Meloidogyne incognita Parasitism in Plants
Authors: Bresso Emmanuel , Fernandez Diana , Amora Deisy X. , Noel Philippe , Petitot Anne-Sophie , de Sa Maria-Eugênia Lisei , Albuquerque Erika V. S. , Danchin Etienne G. J. , Maigret Bernard , Martins Natália F.
Published: October 2019

Root-knot nematodes (RKN), from the Meloidogyne genus, have a worldwide distribution and cause severe economic damage to many life-sustaining crops. Because of their lack of specificity and danger to the environment, most chemical nematicides have been banned from use. Thus, there is a great need for new and safe compounds to control RKN. Such research involves identifying beforehand the nematode proteins essential to the invasion. Since G protein-coupled receptors GPCRs are the target of a large number of drugs, we have focused our research on the identification of putative nematode GPCRs such as those capable of controlling the movement of the parasite towards (or within) its host. A datamining procedure applied to the genome of Meloidogyne incognita allowed us to identify a GPCR, belonging to the neuropeptide GPCR family that can serve as a target to carry out a virtual screening campaign. We reconstructed a 3D model of this receptor by homology modeling and validated it through extensive molecular dynamics simulations. This model was used for large scale molecular dockings which produced a filtered limited set of putative antagonists for this GPCR. Preliminary experiments using these selected molecules allowed the identification of an active compound, namely C260-2124, from the ChemDiv provider, which can serve as a starting point for further investigations.
A Nature-Inspired Design Yields a New Class of Steroids Against Trypanosomatids
Authors: Aguilera Elena , Perdomo Cintya , Espindola Alejandra , Corvo Ileana , Faral-Tello Paula , Robello Carlos , Serna Elva , Benítez Fátima , Riveros Rocío , Torres Susana , Vera de Bilbao Ninfa I. , Yaluff Gloria , Alvarez Guzmán
Published: October 2019

Chagas disease and Leishmaniasis are neglected endemic protozoan diseases recognized as public health problems by the World Health Organization. These diseases affect millions of people around the world however, efficient and low-cost treatments are not available. Different steroid molecules with antimicrobial and antiparasitic activity were isolated from diverse organisms (ticks, plants, fungi). These molecules have complex structures that make de novo synthesis extremely difficult. In this work, we designed new and simpler compounds with antiparasitic potential inspired in natural steroids and synthesized a series of nineteen steroidal arylideneketones and thiazolidenehydrazines. We explored their biological activity against Leishmania infantum, Leishmania amazonensis, and Trypanosoma cruzi in vitro and in vivo. We also assayed their genotoxicity and acute toxicity in vitro and in mice. The best compound, a steroidal thiosemicarbazone compound 8 (ID_1260) was active in vitro (IC50 200 nM) and in vivo (60% infection reduction at 50 mg/kg) in Leishmania and T. cruzi. It also has low toxicity in vitro and in vivo (LD50 >2000 mg/kg) and no genotoxic effects, being a promising compound for anti-trypanosomatid drug development.
The Effect of Biotinylated PAMAM G3 Dendrimers Conjugated with COX-2 Inhibitor (celecoxib) and PPARγ Agonist (Fmoc-L-Leucine) on Human Normal Fibroblasts, Immortalized Keratinocytes and Glioma Cells in Vitro
Authors: Uram Łukasz , Misiorek Maria , Pichla Monika , Filipowicz-Rachwał Aleksandra , Markowicz Joanna , Wołowiec Stanisław , Wałajtys-Rode Elżbieta
Published: October 2019

Glioblastoma multiforme (GBM) is the most malignant type of central nervous system tumor that is resistant to all currently used forms of therapy. Thus, more effective GBM treatment strategies are being investigated, including combined therapies with drugs that may cross the blood brain barrier (BBB). Another important issue considers the decrease of deleterious side effects of therapy. It has been shown that nanocarrier conjugates with biotin can penetrate BBB. In this study, biotinylated PAMAM G3 dendrimers substituted with the recognized anticancer agents cyclooxygenase-2 (COX-2) inhibitor celecoxib and peroxisome proliferator-activated receptor γ (PPARγ) agonist Fmoc-L-Leucine (G3-BCL) were tested in vitro on human cell lines with different p53 status: glioblastoma (U-118 MG), normal fibroblasts (BJ) and immortalized keratinocytes (HaCaT). G3-BCL penetrated efficiently into the lysosomal and mitochondrial compartments of U-118 MG cells and induced death of U-118 MG cells via apoptosis and inhibited proliferation and migration at low IC50 = 1.25 µM concentration, considerably lower than either drug applied alone. Comparison of the effects of G3-BCL on expression of COX-2 and PPARγ protein and PGE2 production of three different investigated cell line phenotypes revealed that the anti-glioma effect of the conjugate was realized by other mechanisms other than influencing PPAR-γ expression and regardless of p53 cell status, it was dependent on COX-2 protein level and high PGE2 production. Similar G3-BCL cytotoxicity was seen in normal fibroblasts (IC50 = 1.29 µM) and higher resistance in HaCaT cells (IC50 = 4.49 µM). Thus, G3-BCL might be a good candidate for the targeted, local glioma therapy with limited site effects.
Sequential Annulations to Interesting Novel Pyrrolo[3,2-c]carbazoles
Authors: Benzi Alice , Bianchi Lara , Maccagno Massimo , Pagano Angela , Petrillo Giovanni , Tavani Cinzia
Published: October 2019

Herein we report a significant, valuable extension of a recently implemented pyrrole benzannulation methodology that, employing versatile nitrodienes from our lab as useful C4 building blocks, led to indole derivatives characterized by unusual patterns of substitution. The 6-nitro-7-arylindoles resulting from suitably derivatized, non-symmetric dienes are of foreseeable synthetic interest in search for new polyheterocyclic systems. As an example, pyrrolocarbazoles with a rarely reported ring fusion were synthesized with the classical Cadogan protocol. Furthermore, the proven easy reducibility of the nitro group to amine will surely open the way to further interesting elaborations.
Promising Approach in the Treatment of Glaucoma Using Nanotechnology and Nanomedicine-Based Systems
Authors: Juliana Fidiniaina Rina , Kesse Samuel , Boakye-Yiadom Kofi Oti , Veroniaina Hanitrarimalala , Wang Huihui , Sun Meihao
Published: October 2019

Glaucoma is considered a leading cause of blindness with the human eye being one of the body’s most delicate organs. Ocular diseases encompass diverse diseases affecting the anterior and posterior ocular sections, respectively. The human eye’s peculiar and exclusive anatomy and physiology continue to pose a significant obstacle to researchers and pharmacologists in the provision of efficient drug delivery. Though several traditional invasive and noninvasive eye therapies exist, including implants, eye drops, and injections, there are still significant complications that arise which may either be their low bioavailability or the grave ocular adverse effects experienced thereafter. On the other hand, new nanoscience technology and nanotechnology serve as a novel approach in ocular disease treatment. In order to interact specifically with ocular tissues and overcome ocular challenges, numerous active molecules have been modified to react with nanocarriers. In the general population of glaucoma patients, disease growth and advancement cannot be contained by decreasing intraocular pressure (IOP), hence a spiking in future research for novel drug delivery systems and target therapeutics. This review focuses on nanotechnology and its therapeutic and diagnostic prospects in ophthalmology, specifically glaucoma. Nanotechnology and nanomedicine history, the human eye anatomy, research frontiers in nanomedicine and nanotechnology, its imaging modal quality, diagnostic and surgical approach, and its possible application in glaucoma will all be further explored below. Particular focus will be on the efficiency and safety of this new therapy and its advances.
Applications of Carbon Nanotubes in Bone Tissue Regeneration and Engineering: Superiority, Concerns, Current Advancements, and Prospects
Authors: Pei Baoqing , Wang Wei , Dunne Nicholas , Li Xiaoming
Published: October 2019

With advances in bone tissue regeneration and engineering technology, various biomaterials as artificial bone substitutes have been widely developed and innovated for the treatment of bone defects or diseases. However, there are no available natural and synthetic biomaterials replicating the natural bone structure and properties under physiological conditions. The characteristic properties of carbon nanotubes (CNTs) make them an ideal candidate for developing innovative biomimetic materials in the bone biomedical field. Indeed, CNT-based materials and their composites possess the promising potential to revolutionize the design and integration of bone scaffolds or implants, as well as drug therapeutic systems. This review summarizes the unique physicochemical and biomedical properties of CNTs as structural biomaterials and reinforcing agents for bone repair as well as provides coverage of recent concerns and advancements in CNT-based materials and composites for bone tissue regeneration and engineering. Moreover, this review discusses the research progress in the design and development of novel CNT-based delivery systems in the field of bone tissue engineering.
Core-Shell Heterostructured and Visible-Light-Driven Titanoniobate/TiO2 Composite for Boosting Photodegradation Performance
Authors: Liu Chao , Gao Xin , Han Zitong , Sun Yao , Feng Yue , Yu Guiyun , Xi Xinguo , Zhang Qinfang , Zou Zhigang
Published: October 2019

Herein, we report a one-dimensional (1D) S-doped K3Ti5NbO14@TiO2 (STNT) core-shell heterostructured composite with an enhanced photocatalytic degradation activity under visible light, which was prepared by a simple reassembly-calcination method using thiourea as the S source. The anisotropically shaped rods are favorable for the rapid transport of photogenerated charge carriers. The substitution of Ti4+ by S6+ is primarily incorporated into the lattice of the TiO2 shell so as to create an intra-band-gap state below the conduction band (CB) position, giving rise to Ti−O−S bonds and thus the visible light response. The presence of electron-deficient S atoms is of benefit to the decreased recombination rate of photogenerated electrons and holes by capturing electrons (e−). Meanwhile, a tight close interface between K3Ti5NbO14 and TiO2 was formed to achieve a nano-heterojunction structure, leading to the fostered separation of its interfacial photogenerated electrons and holes. The visible-light-driven photocatalytic degradation of methylene blue (MB) by STNT composites is higher than that by pure K3Ti5NbO14, owing to the synergistic effects of S doping and heterojunction. A possible photocatalytic mechanism was proposed with a reasonable discussion. This work may provide an insight into constructing highly efficient core-shell photocatalysts used toward sustainable environmental remediation and resource shortages.
Electrodeposition of Nanoparticles and Continuous Film of CdSe on n-Si (100)
Authors: Giurlani Walter , Dell’Aquila Vincenzo , Vizza Martina , Calisi Nicola , Lavacchi Alessandro , Irrera Alessia , Lo Faro Maria Josè , Leonardi Antonio Alessio , Morganti Dario , Innocenti Massimo
Published: October 2019

CdSe electrodeposition on n-Si (100) substrate was investigated in sulfuric acid solution. The behaviour and the deposition of the precursors (Cd and Se) were studied separately at first. Then, we explored both the alternated deposition, one layer by one, as well as the simultaneous co-deposition of the two elements to form the CdSe semiconductor. Varying the deposition conditions, we were able to obtain nanoparticles, or a thin film, on the surface of the electrode. The samples were then characterised microscopically and spectroscopically with SEM, XRD and XPS. Finally, we evaluated the induced photoemission of the deposit for the application in optoelectronics.
The Metabolic and Hepatic Impact of Two Personalized Dietary Strategies in Subjects with Obesity and Nonalcoholic Fatty Liver Disease: The Fatty Liver in Obesity (FLiO) Randomized Controlled Trial
Authors: Marin-Alejandre Bertha Araceli , Abete Itziar , Cantero Irene , Monreal J. Ignacio , Elorz Mariana , Herrero José Ignacio , Benito-Boillos Alberto , Quiroga Jorge , Martinez-Echeverria Ana , Uriz-Otano Juan Isidro , Huarte-Muniesa María Pilar , Tur Josep A. , Martinez J. Alfredo , Zulet M. Angeles
Published: October 2019

The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing worldwide. NAFLD management is mainly focused on weight loss, but the optimal characteristics of the diet demand further investigation. This study aims to evaluate the effects of two personalized energy-restricted diets on the liver status in overweight or obese subjects with NAFLD after a 6 months follow-up. Ninety-eight individuals from the Fatty Liver in Obesity (FLiO) study were randomized into two groups and followed different energy-restricted diets. Subjects were evaluated at baseline and after 6 months. Diet, anthropometry, body composition, and biochemical parameters were evaluated. Liver assessment included ultrasonography, Magnetic Resonance Imaging, elastography, and determination of transaminases. Both dietary groups significantly improved their metabolic and hepatic markers after the intervention, with no significant differences between them. Multivariate regression models evidenced a relationship between weight loss, adherence to the Mediterranean Diet (MedDiet), and a decrease in liver fat content, predicting up to 40.9% of its variability after 6 months. Moreover, the antioxidant capacity of the diet was inversely associated with liver fat content. Participants in the group with a higher adherence to the MedDiet showed a greater reduction in body weight, total fat mass, and hepatic fat. These results support the benefit of energy-restricted diets, high adherence to the MedDiet, and high antioxidant capacity of the diet for the management of NAFLD in individuals with overweight or obesity.