bluuebunny/crossref_metadata_2025 huggingface dataset:
Empowering Climate Resilience: Leveraging Cloud-Computing and Big Data for Community Climate Change Impact Service (C3IS)
Authors: Levin Eugene , Beisekenov Nail , Wilson Michael , Nabaweesi Rosemary , Nguyen Long , Sadenova Marzhan
Published: September 2023

In recent years, the escalating impacts of climate change have necessitated the development of innovative tools to assess and address climate risks. Community Climate Change Impacts Service (C3IS) is an experimental toolkit that provides a powerful solution to accelerate climate risk analysis by offering an interactive API for on-the-fly analysis utilizing the Google Earth Engine (GEE) platform. The toolkit leverages GEE's vast catalog of petabytes of geospatial data and satellite imagery to capture and visualize climate impact risk-related information, enabling scientists and researchers to comprehensively study climate threats. By eliminating the need for pre-processing, modeling, and storage of big data, the C3IS toolkit significantly improves accessibility and usability, enabling informed decision-making when developing resilience strategies to counter climate change impact.
Object Detection in Adverse Weather for Autonomous Driving Through Data Merging and YOLOv8
Authors: Kumar Debasis , Muhammad Naveed
Published: September 2023

For autonomous driving, perception is a primary and essential element that fundamentally deals with the insight into the ego vehicle’s environment through sensors. Perception is a challenging task suffering from dynamic objects and continuous environmental changes. The issue gets worse due to interrupting the quality of perception by adverse weather like snow, rain, fog, night light, sand storm, strong daylight, etc. In this work, we have tried to improve camera-based perception accuracy, such as autonomous driving-related object detection in adverse weather. We proposed the improvement of YOLOv8-based object detection in adverse weather through transfer learning using merged data from various harsh weather datasets. Two prosperous open-source datasets (ACDC and DAWN) and their merged dataset were used to detect primary objects on the road in harsh weather. A set of training weights were collected from training on the individual datasets, their merged version, and several subsets of those datasets according to their characteristics. A comparison between the training weights also occurred by evaluating the detection performance on the above-mentioned datasets and their subsets. The evaluation revealed that using custom datasets for training significantly improves the detection performance compared to the YOLOv8 base weights. And using more images through the feature-related data merging technique steadily increases the object detection performance.
Implementasi Metode ARIMA-GARCH Terhadap Peramalan Konversi Mata Uang Yen ke Rupiah
Authors: Bintang Sirius  , Widyanti Rahayu  , Yudi Mahatma
Published: September 2023

Buying and selling transactions are always used by humans to meet their needs. One of the transaction tools used is money. Each country has its own currency including Japan, with Yen continues to experience a significant decline throughout April 2022 exceeding 5-10%. Therefore, it is necessary to anticipate the rate of increase/decrease in Yen. After testing and forecasting, it was concluded that the most appropriate model for analyzing the data in this study was the ARIMA(3,1,3) - GARCH (1,1) model. This is because the model can overcome the homogeneity of the data. The conversion of Yen to Rupiah currency from August 2022 to July 2023 can be predicted to have fluctuations, and produce a MAPE value of 19.29%, which indicates that the precision level of the ARIMA(3,1,3) - GARCH(1,1) is good enough to use for the conversion data.
PENGEMBANGAN MEDIA POP-UP BOOK PADA PEMBELAJARAN IPA DI SD
Authors: Sinta  , Harlinda Syofyan
Published: September 2023

Development of Pop-Up Book media on science learning in elementary schools. This study aims to determine the validity level of pop-up book media in grade 1 SDS Syalom. The type of research used is development research (R&D). Researchers used the ADDIE development model. The ADDIE model development method consists of 5 development stages including: (1) Analysis (analysis stage), (2) Design (initial product design stage), (3) Development (product development stage), (4) Implementation (product implementation stage) , (5) Evaluation (product evaluation stage). Due to the limitations of researchers and the occurrence of the Covid19 pandemic during the study, the steps used in media validation were carried out online. Based on the validation results from material experts, media experts, design experts, it can be concluded that the quality of the pop-up book media developed is in the appropriate category or can be used for grade 1 elementary school students. Student responses to pop-up book media in the field implementation test got a good response.

 

Keywords: Pop-up book media, science learning, learning media
PENANAMAN NILAI KARAKTER PEDULI LINGKUNGAN PADA SISWA SD NEGERI PLEBURAN 04 SEMARANG
Authors: Jihan Nura Sekar Manik
Published: September 2023

Penelitian Kualitatif  ini bertujuan untuk mengetahui bagaimana cara penanaman nilai karakter peduli lingkungan dan tanggung jawab pada siswa di sekolah adiwiyata. Penelitian ini dilaksanakan di SD Negeri Pleburan 04 Semarang yang merupakan Sekolah PPK dan A
STRATEGI STRATEGI PEER LESSONS SOLUSI TERHADAP MASALAH KEMAMPUAN BERPIKIR KRITIS DAN KETERAMPILAN KOMUNIKASI KELAS V MADRASAH IBTIDAIYAH MUHAMMADIYAH
Authors: ARMIA  , Rian Vebrianto  , Muhammad Sahlan
Published: September 2023

Penelitian ini dilatarbelakangi oleh kemampuan berpikir kritis siswa dan keterampilan Komunikasi yang belum berkembang secara maksimal dalam proses pembelajaran. Selama ini, pelaksanaan pembelajaran didominasi dengan penggunaan metode ceramah yang kegiatannya lebih terpusat pada guru. Penelitian ini menggunakan pendekatan kuantitatif, metode quasi eksperimen dengan desain Nonequivalent Control Group. Populasi dalam penelitian ini adalah seluruh siswa sampelnya kelas V dengan jumlah 41 siswa. Alat pengumpulan data yang digunakan adalah soal tes, lembar observasi, angket, dan dokumentasi. Berdasarkan analisis data diperoleh angket hasil penelitian sebagai berikut: (1) siswa masih mengalami kesulitan dalam menjawab pertanyaan yang membutuhkan proses analisis. (2) siswa masih belum dapat mengidentifikasi permasalahan yang berkaitan dengan lingkungan sekitar; (3) siswa masih cenderung menerima pendapat dari guru atau teman tanpa adanya keinginan untuk memberikan kritik, saran atau bertanya pada saat diskusi; (4) siswa belum bisa berdiskusi aktif  dalam proses pembelajaran (5) siswa masih malu untuk bertnya dan menjawab persoalan secra maksimal., sehingga dapat disimpulkan bahwa untuk mejawab permasalahn di atas perlu suatu strategi yaitu strategi pembelajaran aktif tipe peer lesson dapat diterapkan sebagai salah satu strategi dalam pembelajaran Ilmu Pengtahuan Alam pada Materi Siklus Air karena berdasarkan dokumtasi dari hasil belajar siswa menytakan materi ini sangat sulit untuk difahami oleh siswa.
EFEKTIVITAS PEMBELAJARAN JARAK JAUH TERHADAP PEMBELAJARAN SISWA DI SDIT CENDEKIA PURWAKARTA
Authors: Anggy Giri Prawiyogi  , Andri Purwanugraha  , Ghulam Fakhry  , Marwan Firmansyah
Published: September 2023

Sejak Bulan Maret 2020 seluruh satuan pendidikan di Indonesia memberlakukan program Belajar di Rumah, atau Pembelajaran Jarak Jauh (PJJ), tepatnya sejak corona virus disease atau Covid-19 dinyatakan masuk ke Indonesia. Bupati beserta Kepala Dinas Pendidikan Kabupaten Purwakarta dengan sigap memberikan perintah untuk semua peserta didik untuk belajar di rumah dan memberlakukan Pembelajaran Jarak Jauh mulai pada tanggal 16 Maret 2020 – 29 Mei 2020. PJJ tersebut diberlakukan dalam rangka menghambat penyebaran Virus Covid-19 agar tidak tersebar keseluruh Masyarakat di Purwakarta. Tujuan penelitian ini adalah mendeskripsikan keefektifan Pembelajaran Jarak Jauh bagi para Siswa SDIT Cendekia Purwakarta. Penelitian ini menggunakan penelitian kualitatif dengan rancangan kualitatif deskriptif (studi kasus). Teknik pengumpulan data menggunakan angket/kuisioner secara online menggunakan google form. Pembelajaran jarak jauh dengan beberapa metode cukup efektif untuk dilakukan. Hal tersebut bisa dilihat dari hasil kuisioner yang diberikan kepada responden dari 6 pertanyaan yang diajukan hampir semua rata-rata responden mendukung dan menilai bahwa pembelajaran jarak jauh efektif dilakukan terhadap siswa.
Identifying the interplay between protective measures and settings on the SARS-CoV-2 transmission using a Bayesian network
Authors: Fuster-Parra Pilar , Huguet-Torres Aina , Castro-Sánchez Enrique , Bennasar-Veny Miquel , Yañez Aina Maria
Published: September 2023

During the COVID-19 pandemic, primary healthcare nurses played a crucial role in contact tracing to minimize the Severe
Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) spread. However, contact tracing data were underutilized to explore
the potential ways of virus transmission. Research on community spread, the effectiveness of individual protective measures,
and the impact of different exposure environments is limited. This study focused on the transmission of SARS-CoV-2, aiming
to describe the interplay between prevention measures and characteristics of exposure settings, using the data collated
from a national SARS-COV-2 contact tracing programme to build a Bayesian network (BN) with 11 relevant features, which
could potentially determine features with the strongest influence in SARS-CoV-2 transmission. BNs allow predictions of new
scenarios when hypothetical information is introduced, which makes them of special interest in epidemiological studies. In our
results, ventilation of the setting and time of exposure were the main factors for SARS-CoV-2 transmission. BN analysis can
help decision-makers refine public health campaigns and priorise resources for individuals at higher risk, and also provides
personalized guidance in specific protective measures for different settings or environments.
DRD1 Gene Polymorphism Predict Therapeutic Responses in Patients With Bipolar Mania Treated by Combination of Lithium and Olanzapine
Authors: Sun Fengli , Jin Haiying , Tao Hajian , Chen Haihan , Jin Weidong
Published: September 2023

Objective
To explore the correlation between DRD1 gene rs686 and rs4532 polymorphism and bipolar mania episode and therapeutic effect.
Methods
60 patients with bipolar mania and 40 normal healthy person as the control group were collected, and the DRD1 gene rs686 and rs4532 polymorphism were tested.The difference of rs4532 and rs686 polymorphism and normal control group was compared and correlated to efficacy of treatment with lithium carbonate combined with olanzapine in patients with bipolar mania by YMRS, HAMD and HAMA assessment in the 2nd, 4th, 6th and 8th weekend.
Results
The no statistical significance for the polymorphism difference of DRD1 gene polymorphism of rs686 and rs4532 between patients with bipolar mania and normal control. The patients group is divided into AA group and AG + GG group according to different genotypes of rs686, and also is divided into CC + CT group and TT group according to different genotypes of rs4532.At 8th weekend, YMRS score of AA group higher than that of AG + GG group (8.34 ± 1.23 vs 7.38 ± 1.20P < 0.05). The patient's early effective response rate (EERR,YMRS 2nd weekend reduction rate > 25%) and remission rate( RR,YMRS 8th weekend reduction rate ≥ 80%) are higher that in AA group. The no similar difference of rs4532 was found.
Conclusion
There is a correlation between DRD1 gene rs686 and the therapeutic effect of manic patient. The EERR and RR of rs686 genotype AG + GG group is higher than that of the AA group, suggesting that patients who may contain G alleles can obtain better treatment results.
Numerical and experimental study of energy absorption of PLA calibrated honeycomb structures under quasi-static loading
Authors: hashemi sayedshahabodin , Galehdari Seyed Ali
Published: September 2023

Nowadays, the design and construction of structures with the ability to withstand impact and control energy is of great importance to save human life or equipment. Honeycomb shock absorber structures are the best type of shock absorber due to their low density, high energy efficiency and absorption capacity, low cost and weight. In this research, the energy absorption of the honeycomb structure calibrated from polylactic acid (PLA) has been investigated numerically and experimentally. The studied honeycomb structure was made by a 3D printer after modeling in Autodesk Inventor software. To extract the mechanical properties of PLA material, a dumbbell-shaped model was made for experimental tensile testing, and then numerical simulation was performed in Abaqus software using a quasi-static method and the results were extracted. Analytical review has also been done. The amount of energy absorption of the structure under compressive loading was calculated experimentally using a pressure testing machine, which was obtained in the experimental and numerical analysis, the values of 45 and 42 joules were obtained, respectively. Based on this research, in addition to validating the simulation of the graduated honeycomb structure made of PLA, Also, the main cause of the collapse of the structure has been confirmed. From this structure, in quasi-static loading conditions, it can be expected to have significant energy absorption compared to the same graded sample made of aluminum, and it is introduced as a cost-effective alternative to compression bearings.
Maternal Abnormal Liver Function in Early Pregnancy and Spontaneous Pregnancy Loss: A Retrospective Cohort Study
Authors: Yang Huibin , Tang Tianyi , Zhang Xiaohua , Liu Yinan , Zhou Xiaoyan , Zhang Yanling , Chen Xiaotian , Jin Longmei
Published: September 2023

Background
Spontaneous pregnancy loss (SPL) precedes an increased risk of reduced fertility, while its etiology mechanism remains largely unknown. Liver dysfunction presenting in early pregnancy may represent a pre-existing undiagnosed liver condition affecting foetal development. As a common but easily to be neglected metabolic disorder, little is known about whether and how maternal abnormal liver function in early pregnancy contribute to the incidence of SPL.
Methods
This is retrospective cohort study included 10175 pregnant womenwho were leveraged from the Maternal Health Care Information System (MHCIS) in Shanghai City from Jan 2017 to Dec 2021. Maternal liver dysfunction status was defined as having any elevated liver function biomarker levels (LFBs) at the first antenatal visit. SPL cases were defined as fetal death occurring before 28 weeks gestation. Generalized linear models with binomial family and log link function were used to estimate crude and adjusted risk ratios (aRRs) and 95% confidence intervals (CIs).
Results
Among 10175 leveraged pregnant women, 918 (9.0%) SPL cases were recorded. Maternal liver dysfunction in early pregnancy was associated with a 49% increased risk of SPL (RR 1.49, 95% CI 1.22–1.84). This positive association persisted after adjustment for covariates (aRR 1.55, 95% CI 1.26–1.92). Higher γ-glutamyl transferase (GGT) and alkaline phosphatase (ALP) levels were also linked with increased risk of SPL in a linear fashion (aRRs per 1 standard deviation increase: 1.13, 95% CI 1.08–1.17; 1.13, 1.07–1.20, respectively). These observed positive associations remained significant even after adjustment for multiple corrections. Similar magnitudes of associations between liver dysfunction and SPL were observed in the subgroups of normal weight and overweight pregnant women.
Conclusions
We provide new evidence that maternal abnormal liver function in early pregnancy, as well as GGT and APL, predisposes to an increased risk of SPL. Primary healthcare providers may need to offer appropriate preconception counseling on the management of this modifiable risk factor in women of reproductive age.
Risk factors and outcomes of carbapenem-resistant Escherichia coli nosocomial infections in a Chinese teaching hospital: A retrospective study from 2013 to 2020
Authors: Kong Haifang , Zhang Longtao , Chen Qianqian , Yang Ling , Li Jin , Tian Bin , Hu Zhidong
Published: September 2023

Background: The emergence of carbapenem-resistant Escherichia coli (E. coli) strains poses a considerable challenge to global public health, but little is known about carbapenemase- producing E. coli in Tianjin, China. This study was undertaken to investigate the risk factors for infections with carbapenem-resistant E. coli (CREC) strains.
Methods We conducted a retrospective case‒control study in a tertiary teaching hospital. A total of 134 CREC clinical isolates was collected from the general hospital of Tianjin Medical University from 2013 to 2020. The control group was selected at a ratio of 1:1 from patients with nosocomial carbapenem-susceptible E. coli infections. Risk factors for nosocomial CREC infections and clinical outcomes were analyzed by univariate and multivariate analyses.
Results Multivariate analysis showed that cephalosporin exposure (odd ratio OR=2.01; 95% confidence interval [CI], 1.13-3.59; p=0.02), carbapenem exposure (OR=1.96; 95%CI, 1.10-3.50; p=0.02), glucocorticoids exposure (OR=32.45; 95%CI, 4.15-253.60; p=0.001); and surgical history (OR=3.26; 95%CI, 1.80-5.88; p＜0.001) were independent risk factors for CREC infections. The in-hospital mortality rate in the CREC group was 29.1%, and age>65 years old (OR=3.19; 95%CI, 1.29-7.90; p=0.01), carbapenem exposure (OR=3.54; 95%CI, 1.26-9.98; p=0.02), and central venous catheter insertion (OR=4.19; 95%CI, 1.70-10.31; p=0.002) were independent risk factors for in-hospital mortality in patients with CREC infections.
Conclusion Many factors were found to be involved in nosocomial CREC infections. CREC isolates were resistant to most antibiotics, and reducing the mortality of CREC needs comprehensive consideration of whether the antibiotics were used appropriately, underlying diseases and invasive operation.
An Unusual Presentation of Sinonasal Neuroendocrine Carcinoma: A case report
Authors: Singh Divyanshi , Mathur Anerudh , Chouhan Poonam , Singh Iqbal
Published: September 2023

Introduction: Sinonasal malignancies are rare, squamous cell carcinoma and adenocarcinoma being the most common histologies. Neuroendocrine sinonasal malignancies are even more rare.
Case Presentation: We report a case of a 71 year old who presented with a left infra-auricular swelling which was an unusual presentation for a sinonasal malignancy. Patient was subject to organ preserving surgery to reduce the morbidity.
Conclusion: The treatment modality comprised of both the chemoradiotherapy and surgery for a better prognosis.
Integrability and exact solutions of the (2+1)-dimensional variable coefficient Ito equation
Authors: Chu Jingyi , Liu Yaqing , Chen Xin
Published: September 2023

This paper focuses on the study of the (2+1)-dimensional Ito equation with spatially variable coefficients. The Lax integrability of the equation is confirmed by the Lax pair derived from the Bell polynomials. In addition, the Hirota bilinear form, the Bäcklund transformation and infinite conservation laws of the equation are obtained by the Bell polynomials. More importantly, the ansatz method and the Hirota bilinear method are employed to construct different types of N-soliton solutions and interaction solutions for the (2+1)-dimensional Ito equation with different coefficient functions. All these solutions are presented graphically.
Juvenile Dermatomyositis with Anti-SAE Antibodies in a Moroccan Child Associated with Pseudo-Angioedema: A Case Report
Corresponding author: Khalila NAINIA. Faculty of Medicine and Pharmacy. District: Tilila, Bp 7519 Agence Abb Agadir Al Fidia Cp80060, Agadir, Morocco. k.nainia@uiz.ac.ma / Khalila.nainia@gmail.com
Authors: Nainia Khalila , aouzal mohamed amine , ouafik imane , charhbili mariyam , bouchhab amal , daoudi abdellatif , tizki samira , chakiri radia
Published: September 2023

Background: Juvenile Dermatomyositis (JDM) is the leading cause of non-infectious inflammatory myopathy in children. it is a heterogeneous group of autoimmune diseases characterized by a variable combination of muscular, dermatological, and visceral involvement. Myositis-specific autoantibodies help define homogeneous subgroups with common clinical characteristics and prognosis. Anti-SAE (small ubiquitin-like modifier 1 (SUMO-1) activating enzyme) antibodies are among the most recently discovered specific autoantibodies. the presence of these antibodies is very rare, making it challenging to define clinical features and prognosis in the juvenile form. We report the first case of African patient with juvenile dermatomyositis and positive anti-SAE antibodies, and the only one reported in the word with pseudo-angioedema.
Case Report
A 5-year and 3-month-old Moroccan boy presented to the pediatric emergency department with dysphagia that had been evolving for 2 days, preceded two months earlier by facial erythema associated with fatigue, lower limb pain, difficulty walking, and progressive inflammatory polyarthralgia. On admission, the child had a heliotrope rash with predominant pseudo-angioedema on the lips, periungual telangiectasia, and Gottron's papules over the bilateral interphalangeal and metatarsophalangeal joints. He had more pronounced proximal muscle weakness in the lower limbs. He had no fever, arthritis, calcinosis, cutaneous ulcers, or lipodystrophy. Joint examination was normal, as was the pleuropulmonary examination. The electroneuromyography showed myogenic changes in all four limbs. Laboratory findings showed elevated levels of creatine phosphokinase and lactate dehydrogenase and a mild inflammatory syndrome. The electrocardiogram was normal. Only anti-SAE antibodies were positive.
He was diagnoses with juvenile dermatomyositis and received methylprednisolone bolus therapy followed by oral prednisone which was gradually tapered in combination with weekly intramuscular methotrexate. Dysphagia disappeared within 48 hours, and after two weeks, there was improvement in the muscular score and significant regression of facial angioedema. However, facial erythema persisted after two months despite local and systemic treatment.
Conclusion
We report the first African patient with anti-SAE autoantibody-positive JDM. He is the only one described with pseudo-angioedema. He had a typical dermatological, progressive myopathy, dysphagia. He had not fever, weight loss, respiratory signs, arthritis, calcinosis, cutaneous ulcers, lipodystrophy. He responded well to corticosteroid therapy and methotrexate.
A Novel Robust Detector for Cell-Free Massive MIMO System
Authors: Solanki Mitesh , Gupta Shilpi , Mashru Deepak
Published: September 2023

Massive MIMO increases spectral efficiency and energy efficiency in 5G by using beamforming and spatial multiplexing. It employs a centralized solution to densify a network, resulting in intercellular interference because of its cell-centric design. Massive MIMO systems enable user-centric transmission in cellular networks to overcome inter-cell interference limitations and provide macro-diversity. Massive MIMO distinguishes itself from coordinated, distributed wireless systems with its scalability and cell-free design. This article investigates the immense potential of our proposed detector, this promising technology, and practical deployment issues due to signal coprocessing's increased backhauling overhead. We propose a conjugate gradient (CG)-based detector that enables fast-er convergence and smaller approximated errors for cell-free massive MIMO systems. An analytical approach describes the asymptotic performance of a con-jugate gradient-based likelihood ascent search detector with massive antennas. A joint channel estimation and signal detection (JCD) method is also used for real-world scenarios with imperfect channel state information (CSI). As a result of simulations, our proposed detection scheme outperforms conventional detection schemes.
Behavioral Repertoire of Lahille’s Bottlenose Dolphins During the “cooperative Fishing” With Artisanal Fishers
Authors: Serpa Nathalia , Frainer Guilherme , Santos Bárbara dos , Bortolotto Guilherme A. , Moreno Ignacio B.
Published: September 2023

Many human cultures have been established by positive interactions with wildlife over the last centuries. Lahille’s bottlenose dolphins (Tursiops gephyreus), for example, have historically developed tactics for coastal and estuarine foraging, which sustains a fishing art known as “cooperative fishing” by traditional fishers in estuaries of southern Brazil. Using Unmanned Aerial Vehicles footage, in this study, we explored the behavior of the Lahille’s bottlenose dolphins in the Tramandaí Inlet. We focused on how their behavior repertoire was related with the frequency of net casting by fishers. Close to eight hours of aerial footage recorded from June 2017 to May 2018 were analyzed. Our observations comprise mainly dolphins foraging in the estuary inlet when fishers were present along the shoreline. Dolphins performed at least 25 clearly distinct behaviors and three types of movement patterns. A Generalized Additive Model supported that the fishers interpret a subset of this repertoire (64%) as cues for throwing their cast nets. The behavioral overview of the Lahille’s bottlenose dolphins presented here demonstrates not only a diverse repertoire for this population, but also its clear influence on fishers’ activities. It is clear that ethological, scientific and traditional perspectives should be integrated to better understand the ecological significance of this cooperative fishing, for both dolphin populations and fishers that depend on them.
Exploring Infant Physical Activity Using a Population-based Network Analysis Approach
Authors: Thelagathoti Rama Krishna , Chaudhary Priyanka , Knarr Brian , Schenkelberg Michaela , Ali Hesham H. , Dinkel Danae
Published: September 2023

Background Physical activity (PA) is an important aspect of infant development and has been shown to have long-term effects on health and well-being. Accurate analysis of infant PA is crucial for understanding their physical development, monitoring health and wellness, as well as identifying areas for improvement. However, individual analysis of infant PA can be challenging and often leads to biased results due to an infant’s inability to self-report and constantly changing posture and movement. This manuscript explores a population-based network analysis approach to study infants' PA. The network analysis approach allows us to draw conclusions that are generalizable to the entire population and to identify trends and patterns in PA levels. Methods This study aims to analyze the PA of infants aged 6–15 months using accelerometer data. A total of 21 infants from different types of childcare settings were recruited, including home-based and center-based care. Each infant wore an accelerometer for four days (2 weekdays, 2 weekend days). Data were analyzed using a network analysis approach, exploring the relationship between PA and various demographic and social factors. Results The results showed that infants in center-based care have similar and significantly higher levels of PA than those in home-based care. Moreover, the ankle acceleration was much higher than the waist acceleration, and activity patterns differed on weekdays and weekends. Conclusions This study highlights the need for further research to explore the factors contributing to disparities in PA levels among infants in different childcare settings. Additionally, there is a need to develop effective strategies to promote PA among infants, considering the findings from the network analysis approach. Such efforts can contribute to enhancing infant health and well-being through targeted interventions aimed at increasing PA levels.
Prospective Affirmative Therapeutics of Cannabidiol Oil Mitigates Doxorubicin-Induced Abnormalities in Kidney Function, Inflammation, and Renal Tissue Changes.
Authors: A.Soliman Nabil , Dahmy Samih I. El , Shalaby Amr A. , Mohammed Khadija A.
Published: September 2023

Nephropathy is the decline in kidney function. A promising treatment for a wide range of illnesses is the use of natural materials as natural chemical compounds. The inquiry was conducted to investigate CBD's potential for renal syndrome protection. The five equal groups of fifty male Sprague-Dawley rats weighing 150 ± 25g each were shaped, Group I received distilled water administered orally, while Group II got an intraperitoneal injection of doxorubicin (18 mg/kg bwt). Group III received CBD (26mg/kg bwt) orally, while Group IV received 1 ml of CBD (26 mg/kg bwt) and Group V received Trimetazidine (10 mg/kg bwt), in addition to a single intraperitoneal dose of Doxorubicin (18 mg/kg bwt) on the 11th day for both groups (IV, V). The administration of CBD (26 mg/kg bwt) led to a noticeable improvement in oxidative stress parameters (SOD and GSH) in rats by significantly lowering enzyme activity (ALT and AST), as well as serum Creatinine and urea, (IL 6), and MDA besides the anti-inflammatory accuracy of CBD linked to significant lowering to IL6 DNA frequency concentration in line with histopathology results. As a result of its anti-inflammatory and antioxidant capabilities, cannabidiol may have protective qualities as CBD medication could be linked to controlling renal problems.
Exploring the Potential of Polyploidization as a Breeding Tool for Medicinal Plants: A Case Study on Cumin (Cuminum cyminum L.)
Authors: Hoveida Zahra Sanaei , mortazavian seyed mohammad mahdi , Norouzi Maryam , Sadat-Noori Seyed Ahmad
Published: September 2023

Polyploidization is a major trend in plant evolution that has many advantages over diploidization. Ploidy level manipulation is a powerful breeding tool for many plant species, including medicinal plants. Cumin (Cuminum cyminumL.), as an annual diploid plant belonging to the Apiaceae family, is the second most popular spice worldwide. To identify effective concentrations and target tissues for inducing polyploidy in cumin, three methods of seed treatment, root treatment and apical meristem treatment were tested on a cumin ecotype from South Khorasan under greenhouse conditions. Colchicine was used in varying concentrations (0.5, 0.2, 0.1, 0.05, 0.025% and 0%) for all assays. Different treatment times (12, 24, 36 and 48 hours) were considered for seed and root treatments, while the droplet method was used to treat the apical meristem. The ploidy level of the plantlets was verified by chromosome counts, flow cytometry, and cytology traits. The results showed that the seed and root treatments were not suitable for inducing polyploidy. The most effective method for inducing polyploidy in cumin was the application of colchicine (0.05%) on the apical meristem. However, applying 0.5% and 0.2% concentrations of colchicine on the apical meristem resulted in the wilting of the majority of seedlings. The tetraploid plants showed a significant difference in stomata size and pollen grain size and shape compared to the diploid mother plants.
Monitoring Lake Okeechobee Harmful Algal Bloom populations and dynamics with a long-duration Autonomous Surface Vehicle
Authors: Xomchuk Veronica Ruiz , Duncan Scott , McFarland Malcolm , Beckler Jordon
Published: September 2023

This article describes the main findings of a full year of continuous operation of a 2-meter Autonomous Sail and Solar Surface Drone, the Nav2 (Navocean Inc.), as part of a Harmful Algal Bloom (HAB) monitoring program in Lake Okeechobee. The Nav2 was equipped with a set of water quality and atmospheric sensors, that recorded high frequency measurements (\textless 1 min) and transmitted near real-time information to allow reporting through a web portal for assessment and operation responses. Major findings include detection of HABs early in the year through chlorophyll (chl-a) and phycocyanin (phyco) fluorometric measurements, as well as different spatial scales of variability in the algal patches. The 24/7 high resolution monitoring allowed detection of patch motion and discrimination between growth and motion along a transect. Furthermore, the platform can potentially fingerprint specific HAB species based on the relatively fine-scale spatial expression of the phyco to chl-a ratio, which essentially captures the bloom macrostructure (e.g. surface scums versus more uniform sub-surface waves over 0.1 - 1 km scale). Sensor outputs, when converted to concentrations based on calibrated with pure laboratory standards, did not accurately yield true chl-a or phyco values when compared to validation samples, likely due to the high turbidity of the lake. However, routine solid-state validations of fluorometric measurements proved useful for assessing consistency in optical sensors to check for sensor drift (e.g. to due biofouling), which was not significant. Overall this demonstration shows that the Nav2 can uniquely and reliably provide in situ HAB and environmental monitoring capabilities in a large, turbid, shallow lake. We envision that platform as an innovative technology for water resource managers by providing turn-key long-duration baseline environmental data (hands-off waypoint navigation), early warnings of HABs for protecting human health, and for HAB mitigation monitoring.
A matter of time: Temporal partitioning facilitates coexistence between coyotes (Canis latrans) and gray foxes (Urocyon cinereoargenteus) in temperate forests of Mexico.
Authors: Rodríguez-Luna César R. , Servin Jorge , Valenzuela-Galván David , List Rurik
Published: September 2023

Sympatric species reduce competitive interactions by segregating their ecological niche as a strategy that promotes coexistence. Two main dimensions in which niche differentiation occurs are spatial and temporal axes. Thus, describing the spatiotemporal patterns of sympatric species help us better grasp how species coexist. In Mexico, coyotes (Canis latrans) and gray foxes (Urocyon cinereoargenteus) are sympatric and widely distributed, and information about their temporal and spatiotemporal interactions is needed to explain their coexistence. As an approach to exploring the coexistence between these species in a temperate forest, we pose the following question: Is there temporal or spatiotemporal segregation between sympatric coyotes and gray foxes? We aimed to evaluate indicators of ecological niche segregation through two approaches: i) temporal partitioning, measuring the levels and overlap of daily activity patterns; and ii) spatiotemporal partitioning, through temporal co-occurrence analysis and time-to-encounter analysis. In 2018, we used a camera trap network (n = 43) to measure spatiotemporal patterns of coyotes and gray foxes. We found that coyotes showed a diurnal daily activity pattern while gray foxes were nocturnal, the overlap was low (49%), and daily activity levels varied significantly as coyotes remained active during slightly higher levels of proportion of the circadian cycle (60%) compared with the gray foxes (37%). We found a temporal co-occurrence random pattern (not aggregation/segregation pattern) between species and no avoidance behavior between coyotes and gray foxes was displayed, according to the time-to-encounter analysis. In general, we did not detect segregation patterns between species at the spatiotemporal level, but we found strong evidence of important temporal activity segregation patterns between coyotes and gray foxes as a mechanism that facilitates sympatry, and which likely complements the ecological strategy of coexistence between these species in temperate forests at the southern of the Sierra Madre Occidental, Mexico.
Comparison robot-assisted core decompression combined with human umbilical cord-derived mesenchymal stem cell transplantation and traditional surgery for treatment of osteonecrosis of the femoral head. A retrospective study
Authors: Hu Qin , Shi Juan , Zhu Chao , Zhang Hailong , Wang Bin , Yin Jian , wang bin , liu xinhui
Published: September 2023

Objective To compare the difference in the effect betweeen robot-assisted core decompression combined with human umbilical cord-derived mesenchymal stem cell (hUC-MSC) transplantation and traditional core decompression surgery for osteonecrosis of the femoral head. Methods: Thirty-eight patients with a total of 50 hips who were diagnosed with Association Research Circulation Osseous stage 2 avascular necrosis of the femoral head were included for retrospective analysis. According to the treatment method, they were divided into 2 groups. Twenty patients (28 femoral heads) in the robot group were treated with core decompression assisted by robots combined with human umbilical cord-derived mesenchymal stem cell transplantation (observation group) . The traditional surgery group consisted of 18 patients (22 femoral heads), they were received traditional core decompression operation (control group). Preoperative and postoperative visual analogue scale (VAS) scores, the Harris hip score (HHS) and MRI examination were compared between two groups. Results: The mean follow-up was 17.6 months (12–28 months). There was no significant difference in preoperative VAS and HHS scores and necrotic volume of femoral heads between the two groups. Of note, VAS scores and necrotic volume of femoral heads in robot group were significantly lower than those in traditional surgery group at the last follow-up, HHS scores in robot group were significantly highter than those in traditional surgery group at the last follow-up. Conclusion: Robot-assisted core decompression combined with hUC-MSC transplantation is more effective than traditional core decompression operation for the treatment of femoral head necrosis.
Undercounting diagnoses in Australian general practice: a data quality study with implications for population health reporting
Authors: Canaway Rachel , Chidgey Christine , Hallinan Christine Mary , Capurro Daniel , Boyle Douglas IR
Published: September 2023

Background
Diagnosis can often be recorded in electronic medical records (EMRs) as free text or using a term with a diagnosis code from a dropdown list. Researchers, governments, and agencies, including organisations that deliver incentivised primary care quality improvement programs, frequently utilise coded data only and ignore free text entries. Diagnosis data are reported for population healthcare planning including resource allocation for patient care. This study sought to determine if diagnosis counts based on coded diagnosis data only led to under-reporting of disease prevalence and if so, to what extent for six common or important chronic diseases.
Methods
This cross-sectional data quality study used de-identified EMR data from 84 general practices in Victoria, Australia. Data represented 456,125 patients who attended one of the general practices three or more times in two years between January 2021 and December 2022. We reviewed the percentage and proportional difference between patient counts of coded diagnosis entries alone and patient counts of clinically validated free-text entries for asthma, chronic kidney disease, chronic obstructive pulmonary disease, dementia, type 1 diabetes and type 2 diabetes.
Results
Undercounts were evident in all six diagnoses when using coded diagnoses alone (2.57–36.72% undercount), of these, five were statistically significant. Overall, 26.4% of all patient diagnoses had not been coded.
Conclusion
In Australia the reporting of aggregated patient diagnosis data to government relies on using coded diagnoses which can lead to significant undercount in diagnosis compared to counts that also incorporate clinically validated free-text diagnoses. Diagnosis under-reporting can impact on population health, healthcare planning, resource allocation, and patient care. We propose the use of phenotypes that draw diagnoses from clinically validated text entered improves the accuracy of reports of diagnoses and disease. There are existing technologies and collaborations from which to build trusted mechanisms to provide greater reliability of general practice EMR data used for secondary purposes.
Hyphal connection increases net resource utilization of saprotrophic fungal mycelia by improving local performance
Authors: Fukasawa Yu , Kaga Koji , Akai Daisuke , Takehi Takayuki
Published: September 2023

To identify the functional advantages of hyphal connections in the fungal mycelial networks, we compared the wood decay abilities of the mycelia of a saprotrophic basidiomycete, Phanerochaete velutina, in a soil dish with two or three wood baits. The dishes were surrounded by water, allowing the mycelia to access water if they grew out of the dish. Dishes with two or three baits were attached to or distant from each other, respectively, and representing the ease of creating hyphal bridges between the two dishes. After 8 months of incubation, the weight loss of the wood bait was significantly reduced in the distant pair of dishes compared to the attached pair of dishes. Hyphal outgrowth onto water was observed more frequently in the three bait dishes than the two bait dishes, and water accessibility was positively associated with the water content of the bait, which improved the rate of wood decay. These results suggest that hyphal bridges increase the decay abilities of whole mycelia by improving local performance through the active transfer of water.
Effect of soil organic amendments on sorption behavior of two insecticides and two herbicides
Authors: Fouad Mohamed R. , El-Aswad Ahmed F. , Badawy Mohamed E. I. , Aly Maher I.
Published: September 2023

The effect of biochar, compost, peat and wheat straw at 1 and 5% on adsorption isotherm of chlorantraniliprole (CAP), dinotefuran (DNF), bispyribac-sodium (BPS) and metribuzin (MBZ) was studied in clay loam soil (soil A) and sandy loam soil (soil B). Tested organic amendments significantly reduced the adsorption of soil A except wheat straw at 20–40 µg/mL from CAP, while in soil B amended with peat, compost and biochar improved the CAP adsorption compared to natural soil B. Amendment of tested soils with 1% of biochar, compost and wheat straw had non-significant influence on the adsorption of DNF, while addition of peat reduced the adsorption of DNF. There are no significant differences between the amended-soil A and soil B at low concentrations of BPS while the opposite is true at higher concentrations. All evaluated organic amendments displayed higher efficiency in improving adsorption capacity of tested soils to MBZ except peat and wheat straw at high concentrations of MBZ in case of soil A. The adsorption isotherms of tested pesticides both studied soils amendment with 1% of biochar, compost, peat and wheat straw were satisfactorily described by Freundlich model. It was that adsorption of CAP, DNF, BPS and MBZ at 40 µg/mL on compost was lower than those on other tested adsorbents. The adsorption percentage of CAP was increased significantly on compost and peat amended soil B at the rate of 1% and on compost, peat and wheat straw amended soil A at the rate of 5%. Whereas, 1% of biochar, amended soil A and peat compost and biochar amended soil B increased DNF adsorption percentage compared to the original soils. The amendment of soil A with of 1% of peat and 5% of peat and wheat straw increased the adsorption of BPS compared to that on soil A and B. The adsorption of MBZ in soil A amendment with compost (1%) and biochar, peat and wheat straw (5%) was significantly increased. Also, the MBZ adsorption was significantly increased in soil B amendment with 1% of all tested organic substances.
Biostimulants and Herbicides a Tool to Reduce Non-commercial Yield Tubers and Improve Potato Yield Structure
Authors: Ginter Agnieszka , Zarzecka Krystyna , Gugała Marek , Mystkowska Iwona
Published: September 2023

The basis for the study was a field experiment conducted in 2012-2014 in Wojnów in eastern Poland. The experiment was established in a split-plot arrangement as a two-factor experiment in three replications. The first factor were: three cultivars of edible potato-Bartek, Gawin, Honorata, and the second factor were: five objects of potato cultivation with herbicides and biostimulants: 1-Control object-without chemical protection, 2-herbicide Harrier 295 ZC, 3-herbicide Harrier 295 ZC + biostimulant Kelpak SL, 4-herbicide Sencor 70 WG, 5-herbicide Sencor 70 WG + biostimulant Asahi SL. The aim of the study was to reduce the non-commercial potato yield and improve the yield structure through the application of biostimulants and herbicides, and to determine the relationship between weed infestation and tuber yield. The least amount of weeds and the best destruction efficiency were obtained after the application of herbicide Sencor 70 WG + biostimulant Asahi SL and herbicide Harrier 295 ZC + biostimulant Kelpak SL. Effective reduction of weed infestation contributed to improvement of yield structure and reduction of potato non-commercial yield. Based on correlation coefficients, a significant relationship between weed infestation and potato non-commercial yield was shown.
Whole genome sequencing-based confirmatory methods on RT-qPCR results for detection of foodborne viruses in frozen berries
Authors: Yang Zhihui , Kulka Mike , Yang Qianru , Papafragkou Efstathia , Yu Christine , Wales Samantha Q. , Ngo Diana , Chen Haifeng
Published: September 2023

Accurate detection, identification, and subsequent confirmation of pathogens causing foodborne illness is essential for the prevention and investigation of foodborne outbreaks. This is particularly true when the causative agent is an enteric virus that has a very low infectious dose and is likely to be present at or near the limit of detection. In this study, whole genome sequencing (WGS) was combined with either of two non-targeted pre-amplification methods (SPIA and SISPA) to investigate their utility as a confirmatory method for foods contaminated with enteric viruses. Frozen berries (raspberries, strawberries, and blackberries) were chosen as the food matrix of interest due to their association with numerous outbreaks of foodborne illness. The enteric virus hepatitis A virus (HAV) and human norovirus (HuNoV) were used as the contaminating agents. The non-targeted WGS strategy employed in this study could detect and confirm HuNoV and HAV at genomic copy numbers in the single digit range, and in a few cases identified viruses present in samples that had been found negative by RT-qPCR analyses. However, some RT-qPCR-positive samples could not be confirmed using the WGS method, and in cases with very high Ct values only a few viral reads and short sequences were recovered from the samples. WGS techniques show great potential for confirmation and identification of virally contaminated food items. The approaches described here should be further optimized for routine application to confirm viral contamination in berries.
Bilateral Infiltrative Optic Neuritis as the Presenting Finding in Metastatic Gastric Leptomeningeal Carcinomatosis
Authors: Jiang Alicia , Weber Alec , Simon Luke , Raczek Corinne , Fanucchi Michael , Elefant Daniel
Published: September 2023

Background
To present a rare case of leptomeningeal carcinomatous (LMC) secondary to previously undiagnosed metastatic gastric adenocarcinoma with infiltrative optic neuritis as a presenting finding.
Case Presentation:
A 58-year-old female with no known cancer history presented with 3 months of blurry vision, headaches, and paresthesias. Exam showed bilateral optic disc edema with peripapillary hemorrhages and white infiltrates. Cerebral spinal fluid cytology revealed malignant cells and oncologic workup revealed metastatic gastric adenocarcinoma with signet-ring cells. The patient was treated with systemic chemotherapy. She had a significant improvement in her infiltrative optic neuropathy, both clinically and radiographically, in response to systemic chemotherapy alone. Intrathecal (IT) chemotherapy is often used in the treatment of LMC but was deferred due to the patient’s dramatic improvement with systemic therapy alone.
Conclusions
Bilateral optic disc edema has a broad differential. This case highlights the importance of keeping LMC in mind, even in the absence of a known cancer history. Though IT chemotherapy is often used in treatment, a remarkable response can be seen with chemotherapy alone and management should ultimately be tailored to the individual.