bluuebunny/crossref_metadata_2025 huggingface dataset:
GELADEIROTECA
Authors: Marinho dos Santos Eloiza , De Pinho Maria José
Published: July 2020

O artigo aborda leitura, formação de leitores e democratização da leitura. Tem como objetivo refletir sobre a necessária democratização do acesso à leitura, a partir da experiência do Projeto Geladeiroteca, à luz de fundamentos teóricos construídos em diálogo com os autores: Castrillón, Freire, Petit, Rouxel, Soares, Zilberman, entre outros. Relata uma iniciativa de estudantes da UFMA, campus de Imperatriz-MA, que buscam uma forma criativa de incentivar a leitura na universidade. O projeto nasce numa disciplina ministrada no curso de Ciências Contábeis, com orientação da Profª Celnia Teresinha Bastos, e ganha adesão de estudantes de outros cursos, como Matheus, do curso de Pedagogia. A ideia era criar uma estratégia de compartilhar livros e incentivar a leitura no ambiente acadêmico. Uma geladeira usada, encontrada por um aluno de Contábeis, transforma-se em cenário: a Geladeiroteca. Os estudantes tornam-se protagonistas. Foram utilizadas entrevistas semiestruturadas para colher informações junto à coordenadora do projeto original, professora Celnia, Matheus que se tornou divulgador do projeto e três estudantes que utilizam os livros da Geladeiroteca: uma estudante de Pedagogia e dois estudantes de LCH. Enfim, não basta saber ler, no sentido da ação formal de decodificar a escrita, é preciso tornar-se leitor, como alguém capaz de dialogar com o texto, com o mundo, com a realidade para, a partir dela e com ela, buscar alternativas de transformação.
SILENCIOGRAFÍAS
Authors: Bajour Cecilia
Published: July 2020

Así como es posible detectar huellas del exceso en el decir y en el mostrar tanto en textos como en múltiples mediaciones en prácticas literarias, proponemos el neologismo “silenciografías” para referirnos a marcas de lo no dicho y no mostrado.  Nuestra hipótesis es que las indagaciones sobre el silencio y el ruido son complementarias ya que para reconocer diversas formas de la elipsis se vuelve necesario el reconocimiento de diversas decisiones que apagan el silencio en los textos y en modos de intervenir en situaciones de lectura, escritura y oralidad.
CONVERSAS AO PÉ DAS ÁRVORES
Authors: Oliveira Maria Fernanda Alvito Pereira de Souza , Barreto de Resende Denise
Published: July 2020

Este trabalho busca inserir-se nas discussões atuais sobre literatura e educação, tomando como objeto de estudo a prática docente de uma professora regente do primeiro segmento do ensino fundamental. Duas situações de leitura serão analisadas, com foco nos livros A Árvore Generosa (SILVERSTEIN, 2003) e A Árvore das Lembranças (TECKENTRUP, 2014). O percurso formativo da professora é tematizado, fornecendo o contexto e apontando para a motivação de seu empenho na constituição de um espaço privilegiado para a leitura e a conversa sobre textos literários na rotina das ações docentes e discentes.
BRINCANDO, LENDO E CONTANDO HISTÓRIAS NA EDUCAÇÃO INFANTIL
Authors: Souza Nadilza Maria de Farias , Wanderley Naelza de Araújo Wanderley
Published: July 2020

Este estudo apresenta a Literatura de Cordel como possibilidade de desenvolver a leitura literária na Educação Infantil. Os textos escolhidos para análise foram as adaptações em cordel: Pinóquio: ou o preço da mentira (2009), de Manoel Monteiro e Pinóquio (2015), de Sírlia Sousa de Lima. Desse modo, trazemos reflexões acerca de metodologias e práticas de leitura literária que possibilitam uma maior proximidade da criança com o texto literário de maneira criativa e lúdica embasando-nos nos estudos de Aguiar e Bordini, (1988) e de Girotto e Souza (2010). Acreditamos que os métodos apresentados podem contribuir para a formação de leitores.
O LUGAR DA LITERATURA NOS CURSOS DE LICENCIATURA
Authors: Antunes Benedito
Published: July 2020

O artigo pretende discutir a formação do professor de literatura em cursos de licenciatura, especialmente o de Letras. Embora esses cursos preparem profissionais para atuar em diferentes áreas que pressupõem a competência para ler e escrever como qualidade básica, a maioria desses profissionais destina-se ao magistério, no qual ensinará Língua Portuguesa, disciplina que comporta também a literatura. Essa condição torna indispensável considerar o trabalho com a literatura em sala de aula como inerente ao perfil do futuro professor, o que nem sempre merece a devida atenção dos cursos.
BEST-SELLERS DA CULTURA DE MASSA E FORMAÇÃO DE LEITORES
Authors: Lima Luzimar Silva de , Alves Shirlei Marly
Published: July 2020

Este artigo, recorte da dissertação de Lima (2019), analisa a contribuição que os best-sellers da cultura de massa apresentam para a formação de leitores na escola. Para tanto, realizou-se uma pesquisa de campo em três escolas públicas municipais de 9º ano do ensino fundamental da cidade de Buriti dos Lopes-PI. O suporte teórico que embasa essa pesquisa provém de autores como: Compagnon (1996), Todorov (2009), Barthes (1977), Bloom (2001). A análise dos dados revelou o gosto e apreço que estes estudantes apresentam a respeito dos best-sellers da cultura de massa, compreendendo-os como leituras fruitivas, tendo-as como hábito consolidado.
LITERATURA BRASILEIRA EM CONTEXTO FRANCÓFONO
Authors: Penha Dias Ana Crelia
Published: July 2020

Entrevista com o Diretor Regional para o Caribe da Agência Universitária da Francofonia (AUF), sobre a internacionalização da literatura brasileira em contexto francófono.
LETRAMENTO NA EDUCAÇÃO INFANTIL
Authors: Pinto Francisco Neto Pereira , Borges Gonçalves Solene , Do Espirito Santo L. S. Oliveira Maria
Published: July 2020

O presente artigo propõe uma reflexão sobre o processo de letramento na educação infantil, indagando sobre como a Psicanálise pode contribuir para que o aluno, na leitura e na escrita, possa realmente aprender fazer. Para tanto, são mobilizadas as teorias do campo do letramento e da psicanálise freudolacaniana. Algumas conclusões a que chegamos foi que o educador precisa implicar o aluno em seu aprendizado, ou seja, leva-lo a ler e a escrever, efetivamente, fazendo frente a um comportamento pautado pela lei do menor esforço. Por outro lado, a aluno precisa aceitar o convite e colocar de si em seu aprendizado, sem a esperança de que poderá aprender a ler e a escrever apenas a partir das explicações do professor. Deverá entender que aprenderá fazer, fazendo e, a partir daí, se lançar na aventura do letramento.
SUBALTERNIDADE E ANTI-LITERATURA
Authors: Moraes Renato Almeida de
Published: July 2020

Anti-Literatura objetiva repensar o próprio conceito contemporâneo de literatura. Debruçando-se sobre as principais formas latino-americanas de escrita experimental da década de 1920 até o final do século XX, Shellhorse reforça o potencial da literatura como canal para reflexão e reação radical às culturas política e cultural contemporâneas. Colocando as literaturas brasileira e argentina no cerne de uma novo paradigma interpretativo, Shellhorse desafia as discussões prevalecentes sobre a projeção histórica e a força crítica da literatura latino-americana. Dissecando uma vasta gama de textos e mídias, o autor delineia o potencial subversivo dos modos anti-literários de escrita.
EXPERIÊNCIA, AUTORIDADE E CONSCIÊNCIA CRÍTICA NA FORMAÇÃO DO PROFESSOR DE GRADUAÇÃO EM LETRAS/LITERATURA
Authors: Santos Rosana Cristina Zanelatto
Published: July 2020

Educar é produzir e estimular o amadurecimento da consciência crítica do sujeito, um ato de/em pensamento. Pensar é ser capaz de desenvolver e de explicitar nossas experiências formais e informais. Hoje, além da pobreza dessas experiências, há também o empobrecimento do repertório literário, imagético, cultural e linguístico do sujeito. No entanto, a referência a esse empobrecimento não exclui os produtos da indústria cultural de uma visada crítica, nem de sua leitura; é preciso incluí-los como partícipes de uma tradição/traição. Nos cursos de graduação em Letras, os professores de literatura deveríamos mostrar a ruptura entre o que segue no ensino universitário e o que está posto no cotidiano dos sujeitos e na educação básica. Para isso, é preciso pensar conceitual e relacionalmente três categorias: experiência, autoridade e consciência crítica, perpassadas pelo texto literário como expressão estética.
QUANDO AS PALAVRAS SALTAM À VIDA, GERAM SENTIDOS E CRIAM CONSCIÊNCIA, FORMA-SE UM LEITOR
Authors: Fleck Gilmei Francisco
Published: July 2020

Neste texto buscamos refletir sobre a formação do leitor no espaço escola e de como a leitura pode ser meio de descolonização em sociedade estratificadas. Conscientes de que o processo de humanização ocorre pelo acesso e pelo desenvolvimento da linguagem, compartilhamos considerações sobre a importância da leitura ao longo da formação integral. Apontamos para a necessidade da escola como instituição social de promover nessa trajetória a formação do leitor literário capaz de compreender que a linguagem é material maleável, manipulável à formação de discurso. O texto literário, neste sentido, é o mais precioso médio de confrontar o aluno com esse uso da linguagem. Esse processo de formação do leitor literário em busca da humanização do sujeito deve começar já nas séries iniciais do Ensino Fundamental. Nossas proposições estão fundamentadas nos pressupostos de Lajolo (1993), Candido (2004), Soares (2004), Colomer (2007), Petit (2008) Martins (2012), entre outros. Para que esse processo seja eficiente a escola não só deve atentar aos textos lidos, mas também à forma como a leitura está sendo mediada e incentivada pelos professores e realizada pelos alunos.
CONTRA O SILÊNCIO DO CATIVEIRO
Authors: Figueiredo Cesar Alessandro Sagrillo , Oliveira da Silva Luiza Helena
Published: July 2020

Em entrevista concedida especialmente para o dossiê Literatura e História, da EntreLetras, o jornalista Eduardo Reina, autor de livros que versam sobre a ditadura civil-militar brasileira, falou-nos de seus trabalhos, em especial Cativeiros sem fim: as histórias dos bebês, crianças e adolescentes sequestrados pela ditadura militar no Brasil, publicado em 2019 pela Almedina.  O livro possui como objetivo principal investigar a trajetória de crianças filhas de militantes políticos e oponentes do regime militar, que foram sequestradas durante a ditadura civil-militar (1964-1985), sobretudo filhos de militantes e camponeses da Guerrilha do Araguaia, ocorrido no Sudeste do Pará e Norte do Tocantins, entre 1972 e 1975.  Como resultado de pesquisa, na entrevista o autor desnuda esse crime de lesa-humanidade até hoje não reconhecido pelo Estado brasileiro, bem como aponta acerca dos medos e traumas presente na Região do Bico do Papagaio/TO, latente ainda em virtude da ação militar empreendida no período.
The Inconsistency of ICSID Awards Over Argentina Cases
Authors: Aiyub Kadir M. Ya'kub , Farsia Lena
Published: July 2020

This paper discusses the inconsistency of International Centre for Settlement of Investment Disputes (ICSID) awards over an emergency situation in Argentina in 2001.  Utilising a doctrinal methodology under Third World Approach to International Law (TWAIL) paradigm, this paper explores the argument set out in Argentina case in the first trial and its appeals, then makes an effort to find out the better and systematic argument for Argentina. Therefore, this paper contributes to factually understanding the different argument from two perspectives in ICSID proceedings which has been contested and herewith proposed a better formulated argument for the future of ICSID awards making by placing economic development in Third World States as a basis of argument. Hence this argument can be used for the similar cases in the ICSID in future.
New Paradigm in Natural Resources Management: Securing Indigenous Peoples Rights
Authors: Patittingi Farida
Published: July 2020

The multi-decade struggle of indigenous communities in Indonesia to gain recognition of their collective rights and the reluctance of the state to act on their demands, now has come to a bright spot. The rights of indigenous peoples in natural resources management –in land and forests– get more recognition as well as protection since the Constitutional Court’s decision on forest law. The recognition of indigenous peoples and their traditional rights must be followed by exclusive rights to control and managing resources in their environment, such as land or forests, as the main source of livelihood for indigenous peoples (lebensraum). Hence, a legal policy is needed from the government that regulates and provides strict and clear recognition criteria for its existence and their rights to natural resources.
Work and Lives in Makassar Coastal Community: Assessing the Local Government Policy
Authors: Sakharina Iin Karita , Daud Aidir Amin , Hasrul Muh. , Kadarudin Kadarudin , Assidiq Hasbi
Published: July 2020

The Makassar City Regional Government formulated a policy that previously carried out Mapping conducted on the less prosperous Coastal community, so departing from the mapping results obtained then formulated a policy as in the development of human resources will be carried out in areas that most need to become a poverty pouch. Local government is the most relevant party to be responsible for increasing the budget. All components, which are responsible for improvement, for the Coastal community, and of course for all parties, who are responsible for improving the welfare of the Coastal community, each related agency provides a budget that is appropriate to the community's needs and the duties and functions of each of the relevant agencies. . In addition, it is in the interests of government policies that harm the Coastal community. The implementation of the reclamation policy which is detrimental to fisheries is of course counterproductive to other policies aimed at the welfare of the Coastal community.
Evaluation of the Regulation Changes on Environment and Forestry in Indonesia
Authors: Helmi Helmi , Syam Fauzi , Nopyandri Nopyandri , Putra Akbar Kurnia
Published: July 2020

This article aims to examine the correlation between the concept of proper enforcement of the law as stipulated in Article 5 (2) of the 1945 Constitution of Indonesia and the establishment and implementation of government regulation on environment and forestry. This article is a normative legal research with statute, historical, and conceptual approaches. The result shows that proper legal enforcement means two things, namely, establishment and enactment of government regulation by the President and the content of the regulation that does not contradict the law. Failure to comply with the law means the President does not establish or enforce a government regulation as mandated or the content of the regulation is not in line with the law.  If the President does form or enforce the implementation of government regulation, this means that the President violates his oath and promise to uphold the Constitution and to serve the nation. If the content of the regulation contradicts with the law, it can be canceled. In this situation, the government needs to realign the content of existing regulations. The ministry involved in legal drafting is called to oversee the content and follow through with revisions. All party involves in the making of law and regulation, such as the People Representatives, the President, or the Minister, is reminded to carefully formulate a government regulation.
Developing computational mathematics provision in undergraduate mathematics degrees
Authors: Elwes Richard , Sturman Rob
Published: July 2020

Over the last ten years we have comprehensively embedded computational mathematics, and in doing so programming, into the undergraduate mathematics degree programmes at the University of Leeds. This case study discusses some of the practical, organisational and pedagogical issues we encountered, and how we addressed them.
LOOKING AT A PORTRAIT OF STUDENT ARGUMENTATION SKILLS ON THE CONCEPT OF INHERITANCE (21ST CENTURY SKILLS STUDY)
Authors: Miaturrohmah Miaturrohmah , Fadly Wirawan
Published: July 2020

This research was conducted to obtain a picture of the level of argumentation skills of students in science learning. This research is a starting point to find out the level of 21st century skills that are very important students have, one of which is argumentation skills. The method used is a qualitative study with a survey design and unstructured interviews with a sample of class IX A students in one of the Ponorogo District Junior High Schools selected by cross sectional random sampling. The results showed that the average of students 'argumentation skills was 71.528, which meant the level of students' argumentation skills in learning science was still relatively low. The results of this study become a reference for further research to improve students' argumentation skills in learning science especially1 Tadris IPA, IAIN Ponorogo, Indonesia
PROBLEM BASED LEARNING MODEL THROUGH CONSTEXTUAL APPROACH RELATED WITH SCIENCE PROBLEM SOLVING ABILITY OF JUNIOR HIGH SCHOOL STUDENTS
Authors: Sulastri Sulastri , Pertiwi Faninda Novika
Published: July 2020

The purpose of this study is to determine the effect of the problem based learning model of learning on students' ability to solve science problems at SMPN 1 Siman Ponorogo. That is because PBL learning models that take advantage of real-world (contextual) problems will provide opportunities for students to hone, grow, and improve their ability to solve science problems so that they can be applied in dealing with problems in daily life. This study uses a quantitative approach. This research method is quasi experimental design and the type of research used is experimental research with a non-equivalent group design experimental design. Data collection was performed using posttest questions which were then analyzed using inferential statistical data analysis techniques. The sampling technique used in this study is purposive sampling. The population in this study were all eighth grade students of SMPN 1 Siman. The sample in this study was class VIII A as an experimental class and Class VIII B as a control class. From the study obtained post test results which showed that the class with a problem based learning model through a contextual approach had a higher average value when compared to the class using conventional methods, namely 84.54 and 50.45. Hypothesis test results obtained tcount> ttable is 11.747> 1.681, so Ha is accepted and H0 is rejected. From these calculations it can be concluded that there is a significant influence on the Problem Based Learning model through a contextual approach to the ability to solve science problems of Grade VIII students at SMPN 1 Siman Ponorogo.
The Urbanization Process of São Carlos City between 1980 and 2016
Authors: Stanganini Fábio , Lollo José Augusto
Published: July 2020

The objective of this work was to analyze the progress of the urbanization process and the environmental impacts in the municipality of São Carlos/SP, due to the changes in the spatial dynamics and the alterations in the landscape. In this case, the observed aspects bring as consequences: the anthropic activities, the environmental degradation, the urban area growth and the environmental impacts. The aid of the spatial analysis tools, such as the Geographic Information Systems (GIS), the remote sensing and the digital cartography, allowed to observe and monitor the current situation of the urbanized area through a multitemporal analysis, that comprised the years 1980, 1990, 2000, 2010 and 2016. As an outcome, a worrying situation from the uncontrolled growth over the years has been observed, which arised as a consequence of the dispersion process on the ground.  This indicates a need to increase control specifically in the effectiveness of the urban management tools. As an analysis the study endorses that the environmental problems continued to grow because of the unstrategic urbanization process, which possess a potential for the degradation of the areas that are not yet affected by levitating the: risks of the environmental impacts; consumption of the natural resources and pressures on them. In this way, a set of technical information from the maps is of utter importance which can provide aid to the management organs in their decision-making.
SURO-2/TMEM39 Facilitates Collagen Secretion through the Formation of Large COPII Vesicles
Authors: Lee Kiho , Sung Jee Young , Lee Saerom , Lim Gaeun , Jung Kyung Jin , Chung Jeong Min , Jung Hyun Suk , Kim Yong Yun , Shim Jaegal
Published: July 2020

Fibrosis of various tissues is a typical disease caused by excessive production and secretion of extracellular matrix. We used Caenorhabditis elegans to investigate the formation of large transport vesicles to understand collagen secretion, a critical factor in fibrosis formation. The suro-2 mutant displays obvious defects in collagen secretion and cuticle structure including a rupture phenotype in early adults. Transmission electron microscopy exhibited that the cuticle thickness of the suro-2 mutant was severely reduced. SURO-2/TMEM39 has 8 transmembrane domains and localizes in the endoplasmic reticulum (ER) membrane. SURO-2 interacts directly with NPP-20/Sec13, a component of the coat protein II (COPII) complex responsible for ER-to-Golgi transport. SURO-2 and NPP-20 localized at the same large puncta, a large COPII vesicle enough to accommodate collagens. We report here that SURO-2/TMEM39 is highly conserved among animal species and is a specialized regulator of bulky collagen secretion rather than general transport in C. elegans.
Efficacy of Integrative Chinese-Western Medicine Treatments for COVID-19 Patients in ICU in Yichang, Hubei, China
Authors: Yuan Ziwen , Zhang Min , Li Jingcheng , Peng Ting , Liang Chen , Lin Zhengfeng , Ming Quan , Peng Qiuping , Fang Run , Zhao Weijun , Luo Bin , Liu Hongbo , Wei Xiaojie , Huang Wusong , Shao Yanfeng , Xiong Shengnan
Published: July 2020

BackgroundThe prognosis of severe COVID-19 patients is poor. Traditional Chinese Medicine had an advantage in keeping microenvironmental balance in treating SARS and COVID-19.MethodsThis prospective cohort study compared the efficacy and safety of integrative Chinese-Western medicine (ICWM) treatments with Western medicine (WM) treatments in severe or critically ill patients. The outcomes included: mortality, hospital stay in ICU, days with ventilator-assisted ventilation, etc.ResultsA total of 72 confirmed COVID-19 patients in ICU were included. The median age of patients was 66 years (IQR: 53-77.5), and there were 32 female patients (44.4%). There were no significant differences in laboratory tests and complications after treatments between groups. A total of 36 (50%) patients died during hospitalization, and the mortality in the ICWM group (28.6%) was significantly lower than that of the WM group (63.6%, adjusted P=0.011). And the time of assisted ventilation was shorter in the ICWM group (adjusted P=0.341). However, the median hospital stay was significantly longer in the ICWM group (18 vs. 14 days, adjusted P＜0.05).ConclusionsICWM treatments could significantly reduce mortality for severe or critically ill patients with COVID-19, and it was safe and cost-effective to add Chinese medicine.
Pengembangan Petunjuk Praktikum Kimia Berbasis Kontekstual pada Materi Elektrolit dan Non-Elektrolit
Authors: Inayah Nurul
Published: July 2020

Penelitian ini dilatar belakangi oleh kebutuhan peserta didik kelas X MAN 2 Semarang dalam pemahaman materi dengan menggunakan metode praktikum berbasis kontekstual sehingga peserta didik dapat menghubungkan materi dengan kehidupan nyata peserta didik. Penelitian ini menggunakan metode penelitian dan pengembangan yang biasa dikenal dengan istilah Research and Development (R&D). Model pengembangan yang direncanakan dalam penelitian ini menggunakan model pengembangan 4-D. Model pengembangan 4-D tahap-tahapnya yaitu Define, Design, Develop, dan Disseminate. Hasil penelitian di MAN 2 Kota Semarang (1) Pada aspek kognitif tingkat kelulusan klasikal peserta didik mencapai 93 % terhadap materi sehingga dapat dikatakan efektif. (2) Pada aspek afektif  diperoleh hasil sebanyak 94,36 % nilai afektif peserta didik untuk mengikuti pembelajaran dikatakan dengan tingkat pencapaian Sangat Tinggi. (3) Pada aspek psikomotorik hasil pencapaian diperoleh sebanyak 96,09 % dengan kriteria pencapaian Sangat Tinggi. (4) Pada uji kelayakan buku petunjuk praktikum melalui angket tanggapan peserta didik dengan tingkat pencapaiannya ialah 91,2 % berada pada kriteria efektif. Buku petunjuk praktikum kimia berbasis kontekstual materi elektrolit dan non-elektrolit yang dikembangkan ini terbukti efektif dan layak digunakan dalam proses pembelajaran.
Potential impact of floating solar panels on water quality in reservoirs; pathogens and leaching
Authors: Mathijssen D. , Hofs B. , Spierenburg-Sack E. , van Asperen R. , van der Wal B. , Vreeburg J. , Ketelaars H.
Published: July 2020

Application of floating solar panels is especially suited for the Netherlands, given the limited availability of land (surface area). Evides water company owns and operates several open storage reservoirs which can be used for installation of these panels, but the installations could affect the local environment, naturally occurring processes and water quality. In this research, we evaluate leaching of various substances and possible effects based on a theoretical approach following the Analysis of Microbiological Safety of Drinking water (AMSD method). Besides the water quality issues, the ongoing research at Evides will focus on the effect of the floating solar installation on algae, microbiological and chemical parameters, birds, aquatic flora and fauna, and also look into possibilities of applying alternative storage possibilities using hydrogen.
The impact of climate change on water and energy security
Authors: Goodarzi Mohammad Reza , Vagheei Hamed , Mohtar Rabi H.
Published: July 2020

The interdependent fundamental systems, water and energy, face abundant challenges, one of which is climate change, which is expected to aggravate water and energy securities. The hydropower industry's benefits have led to its development and growth around the world. Nonetheless, climate change is expected to disturb the future performance of hydropower plants. This study looks at the Seimareh Hydropower Plant to assess the potential vulnerability of hydropower plants to climate change. Results indicate that climate change will affect the area's hydrological variables and suggest an increase in temperatures and decrease in precipitation during a 30-year future period (2040–2069). It is predicted that Seimareh Dam's inflow will decrease by between 5.2% and 13.4% in the same period. These hydrological changes will affect the Seimareh plant's performance: current predictions are that the total energy produced will decrease by between 8.4% and 16.3%. This research indicates the necessity of considering climate change impacts in designing and maintaining hydraulic structures to reach their optimal performance.
Comparison of Bromhexine and its Active Metabolite - Ambroxol as Potential Analgesics Reducing Oxaliplatin-induced Neuropathic Pain - Pharmacodynamic and Molecular Docking Studies
Authors: Furgała-Wojas Anna , Kowalska Magdalena , Nowaczyk Alicja , Fijałkowski Łukasz , Sałat Kinga
Published: July 2020

Background:

Painful peripheral neuropathy is a dose-limiting adverse effect of the antitumor drug oxaliplatin. The main symptoms of neuropathy: tactile allodynia and cold hyperalgesia, appear in more than 80% of patients on oxaliplatin therapy and are due to the overexpression of neuronal sodium channels (Navs) and neuroinflammation.

Objective:

This study assessed antiallodynic and antihyperalgesic properties of two repurposed drugs with antiinflammatory and Nav-blocking properties (bromhexine and its pharmacologically active metabolite - ambroxol) in a mouse model of neuropathic pain induced by oxaliplatin. Using molecular docking techniques, we predicted targets implicated in the observed in vivo activity of bromhexine.

Methods:

Oxaliplatin (a single intraperitoneal dose of 10 mg/kg) induced tactile allodynia and cold hyperalgesia in CD-1 mice and the effectiveness of single-dose or repeated-dose bromhexine and ambroxol to attenuate pain hypersensitivity was assessed in von Frey and cold plate tests. Additionally, Veber analysis and molecular docking experiments of bromhexine on mouse (m) and human (h) Nav1.6-1.9 were carried out.

Results:

At the corresponding doses, ambroxol was more effective than bromhexine as an antiallodynic agent. However, at the dose of 150 mg/kg, ambroxol induced motor impairments in mice. Repeated-dose bromhexine and ambroxol partially attenuated the development of late-phase tactile allodynia in oxaliplatin-treated mice. Only 7-day administration of bromhexine attenuated the development of late-phase cold hyperalgesia. Bromhexine was predicted to be a strong inhibitor of mNav1.6, mNav1.7, mNav1.9, and hNav1.7-hNav1.9.

Conclusion:

The conversion of bromhexine to other than ambroxol active metabolites should be considered when interpreting some of its in vivo effects. Nav-blocking properties of bromhexine (and previously also predicted for ambroxol) might underlie its ability to attenuate pain caused by oxaliplatin.
Chemistry and Antioxidant Potential of Phytoconstituents from Aegle Marmelos Fruit-Shell
Authors: Chaubey Ankita , Dubey Ashok K.
Published: July 2020

Background:

Oxidative stress is among the main causes of metabolic disorders. Hence, there is a need to
discover potent antioxidants for therapeutic applications.

Objective:

The objective of this study has been to investigate the phytoconstituents of the methanolic extract of the
hard shell of Aegle marmelos fruit and their antioxidant potential.

Methods:

Methanolic extract was fractionated using different solvents by liquid-liquid extraction. Characterization of
the phytoconstituents was done by using phytochemical tests and GC-MS analysis. The free radical scavenging
activity, total reducing power, lipid peroxidation inhibition and cell protection assays against oxidative stress were
performed with methanolic extract and its fractions.

Results:

Therapeutically significant class of compounds, for example, polyphenols, glycosides and sterols were
revealed in the hard-shell extract. Differential separation of compounds was achieved by liquid-liquid extraction
using different solvents. Six compounds: 4-Hydroxybenzeneacetic acid; 5-Oxo-pyrrolidine-2-carboxylic acid methyl
ester; 1-[3-Methyl-3-Butenyl] Pyrrolidine; Trans-sinapyl alcohol; 5-[Hydroxymethyl]-2-furaldehyde and 2,4-
Dihydroxy-2,5-dimethyl-3[2H]-furan-3-one, identified in the fruit-shell extract, are being reported for the first time
from this plant. Strong antioxidant potential of the extract was evident from efficient scavenging of free radicals. The
extract also conferred protection to yeast cells against oxidative damage.

Conclusion:

Results showed that the hard shell of the Aegle marmelos fruit was a potent source for antioxidant
compounds, which can be developed for therapeutic applications in the control and management of metabolic
diseases.
Study of Photocatalytic Degradation, Kinetics and Microbial Activities of Copper (II) Soya Urea Complex in Non-Aqueous Media
Authors: Sukhadia Vandana , Sharma Rashmi , Meena Asha
Published: July 2020

The aim of this research work is to synthesise, study and analyse photocatalytic degradation,
kinetics and microbial activity of new surfactant Copper (II) soya urea complex (CSU). Photocatalytic
degradation has gained the attention of the scientific community throughout the world due to its multiple
applications in environment, energy, wastewater treatment, pollution control, green chemistry, etc.
Copper (II) soya urea complex has been synthesized and characterized through FT-IR, NMR, ESR
studies. Present work deals with the study of photocatalytic degradation of Copper (II) soya urea complex
by using ZnO as a semiconductor. This study employs a semiconductor catalyst using non-polar
and non-aqueous solvent in photocatalytic degradation. The reaction rate is chosen as the photocatalytic
activity, which has been governed by several factors. Antibacterial activities of the Copper (II) complex
have also been studied against Staphylococcus aureus. Optical density (O.D.) was measured after
different time intervals spectrophotometrically to measure the degradation of the complex. Mueller-
Hinton agar medium was used for antimicrobial activity of synthesized compounds at different concentrations
by disk/well diffusion susceptibility testing. Plot of 2+log O.D. (absorbance) versus time was
plotted and found linear. The heterogeneous photocatalysis followed pseudo-first-order reaction kinetics.
The present study suggests that Copper (II) soya urea (CSU) complex shows antibacterial activity
against Staphylococcus aureus at different concentrations. The results were used to determine the rate
of photocatalytic degradation of CSU complex. It has been found that the rate of degradation varies
with different parameters like concentration of complex, amount of catalyst, light intensity, solvent polarity,
etc. CSU complex derived from soyabean oil has been shown an inhibitory effect on the growth
of S. aureus, which may cause skin disease.
Sustainable Pharmaceutical Preparation Methods and Solid-state Analysis Supporting Green Pharmacy
Authors: Nugrahani Ilma
Published: July 2020

Every "entity" or compound has physical and chemical properties as references for the synthesis and determination of the entity's structure. Thermodynamically, solid-state is the most stable matter in the universe and to be the ideal form in structure elucidation of pharmaceutical. The dry treatments, such as mechanochemistry, microwave heating, and the using of deep eutectic agent are becoming popular. These techniques are viewed as futuristic methods for reducing environmental damage, in line with "green pharmacy" concept. On the other hand, solid-state analysis methods from the simplest to the most sophisticated one have been used in the long decades, but most are for qualitative purposes. Recently many reports have proven that solid-state analysis instruments are reliable and prospective for implementing in the quantitative measurement. Infrared spectroscopy, powder x-ray diffraction, and differential scanning calorimetry have been employed in various kinetics and content determination studies. A revolutionary method developed for structural elucidation is single-crystal diffraction, which is capable of rapidly and accurately determining a three-dimensional chemical structure. Hereby it is shown that the accurate, precise, economic, ease, rapid-speed, and reliability of solidstate analysis methods are eco-benefits by reducing the reagent, catalyst, and organic solvent.
Melatonin and Regulation of Immune Function: Impact on Numerous Diseases
Authors: Bondy Stephen C. , Campbell Arezoo
Published: July 2020

:

Melatonin is well known as a neuroendocrine hormone that promotes sleep. However,
the many other attributes of melatonin are less apparent and not as widely appreciated. The purpose
of this review is to summarize the qualities of melatonin relating to immune function. The relevance
of melatonin in partially or wholly restoring optimal function, in a series of disorders related
to immune dysfunction, is addressed in this report. This includes the potential relief of both autoimmune
diseases and many other ailments involving abnormal immune responses, including the
overall diminished effectiveness of body defenses occurring with aging. Disease states affecting a
wide range of organ systems have been reported as benefitting from melatonin administration and
are discussed here. A separate section addresses the potential role of melatonin in the mitigation of
age-related neurological diseases, in view of the increasing importance of this area. The likely
mechanistic basis of the properties by which melatonin may confer protection by its acting on immune
function is also described.
Short-term and long-term effects of fuel carrier’s price rise on consumer price inflation in Iran
Authors: Norouzi Nima
Published: July 2020

Introduction:

Oil is one of the primary commodities of all countries in the world and is, in essence, the energy
base of all that we know as transportation. Therefore, derivatives price fluctuations, especially those of fuel and oil
derivatives, are the main concerns of the policymakers because they can cause serious problems, such as inflation in
commodity prices.

Objective:

The impact of the price of fuel carriers on food price index remains a subject of debate and research. the aim of
this paper is to develop a model to define the inflation regime in iran and then to estimate gasoline and diesel price impact
in the inflation anount.

Method:

In this study, using the central bank time series and available data on energy balance and World Bank data banks
a non-linear distributed online delay regression modeling is developed to analyze the relationship between fuel price and
basic commodity inflation.

Results:

the results show that gasoline prices have an impact. In the long run, it doesn't have much in the way of prices,
but diesel can be somewhat effective in raising prices, which can exacerbate poverty in the community that needs special
attention.

Conclusion:

It was also found that the price of diesel is harmful to the economy because it can stimulate inflation in the
long term. However, in the short term, diesel does not cause any significant inflation in the prices. While the price of
gasoline can have many short term social effects, therefore, the Iranian government must control the price of diesel fuel to
prevent long-term food price inflation.
Evaluation of Cucurbita Argyrosperma as Anti-Angiogenic Chemopreventive,
Anti-Diabetic, Anti-Carcinogenic, and Anti-microbial Therapy
Authors: Elbossaty Walaa Fikry
Published: July 2020

:

Cucurbita Argyrosperma (pumpkin) is considered a sacred fruit, as it was mentioned in the holy Quran. And
from the grace of God Almighty upon his prophet Yunus, provides him with a pumpkin tree and the reason for choosing
this fruit, the science has proven it after nearly 5,000 years of its mention in the Holy Quran .Scientific research has proven that this tree is rapidly growing and is also rich in Carotenoids that act as antioxidants, protecting the tissue from damage if free radicals are exposed, as this fruit contains the important protein in the growth of tissues and fibers, which has
an important role in maintaining the digestive system. It was found that pumpkin plays an important role in treating diabetes, atherosclerosis, obesity, heart disease and colon cancer.
All of this, in addition to presence of many minerals in this fruit, which have an effective role in maintaining the integrity
of the bones, teeth, muscles, and nerve cells. This is not all. It was found that the chemical compounds in pumpkin have
an effective role in limiting the growth of some microorganisms. Therefore, pumpkin is used as a treatment for microbes
and also helps in raising the efficiency of the immune system and thus protects the body from exposure to diseases.
Влияние примеси никеля на гальваномагнитные свойства и электронную структуру PbTe
Authors: Скипетров Е.П. , Ковалев Б.Б. , Шевченко И.В. , Кнотько А.В. , Слынько В.Е.
Published: July 2020

The phase and elemental composition and galvanomagnetic properties (4.2 < T < 300 K, B < 7 T) of Pb1-yNiyTe alloys are studied at a variation of the nickel impurity concentration along the single-crystal ingot synthesized by the Bridgman-Stockbarger technique. It is shown that the solubility of nickel does not exceed 0.35 mol %. Anomalous temperature dependences of the Hall coefficient and temperature and field dependences of magnetoresistance are found. To explain the results, it is assumed that an n-type inversion layer appears on the surface of the samples and that there are several competing conduction mechanisms in the samples. A model of the Pb1-yNiyTe electronic structure is proposed that assumes pinning of the Fermi level within the Ni impurity band, located at the edge of the valence band and moving deeper into it with increasing temperature.
Особенности механизма электропроводности в γ-облученных монокристаллах TlInSe-=SUB=-2-=/SUB=- под гидростатическим давлением
Authors: Мадатов Р.С. , Гасымов Ш.Г. , Бабаев С.С. , Алекперов А.С. , Мовсумова И.М. , Джабаров С.Г.
Published: July 2020

Исследовано влияние гидростатического давления до 10 кбар на электропроводность γ-облученных цепочечных монокристаллов TlInSe2 с удельным сопротивлением rho~108 Ом·см. Установлено, что наблюдаемые аномалии электропроводности облученных образцов TlInSe2 при дозах облучения D<100 крад и D>100 крад связаны с упорядоченной перестройкой дефектов, в состав которых входят межузельные атомы катионов и анионов. Характер аномального изменения, барические зависимости удельного сопротивления rho(P) в облученных образцах свидетельствуют о том, что под действием давления формируются локальные энергетические уровни за счет макроскопических скоплений радиационных дефектов, в результате чего изменяется энергия уровня Ферми, изменяется концентрация носителей заряда. Ключевые слова: гидростатическое давление, электропроводность, цепочечные монокристаллы, γ-облучение, радиационные дефекты, барическая зависимость.
"Брэгговская" решетка заселенности электронов, наводимая в гетероструктуре Al-=SUB=-x-=/SUB=-Ga-=SUB=-1-x-=/SUB=-As-GaAs-Al-=SUB=-x-=/SUB=-Ga-=SUB=-1-x-=/SUB=-As ее собственным стимулированным пикосекундным излучением
Authors: Агеева Н.Н. , Броневой И.Л. , Забегаев Д.Н. , Кривоносов А.Н.
Published: July 2020

It was shown that the modulation of the spectrum of stimulated picosecond emission generated in the AlxGa1-xAs–GaAs–AlxGa1-xAs waveguide heterostructure upon optical pumping of GaAs, and a number of previous experimental results become explainable under the assumption that emission forms a symmetric modification of the “Bragg” population lattice of nonequilibrium electrons GaAs. Boundary conditions defining the lattice design are proposed. In particular, in order to satisfy them, the lattice can only change discretely. The latter is consistent with a change in the modulation of the light absorption spectrum in GaAs, which reflects the modulation of population depletion created by emission in a high-quality heterostructure. The latter is consistent with a change in the modulation of the light absorption spectrum in GaAs, which reflects the modulation of population depletion created by emission. Inducing the lattice, i.e. burning out spatial holes, is one of the reasons for the multimode nature of emission, competition and switching of its modes, modulation of the gain spectrum (burning out frequency holes). The same is possible in a semiconductor laser, as in a waveguide.
Дисперсионный транспорт водорода в МОП-структурах после ионизирующего облучения
Authors: Александров О.В.
Published: July 2020

Показано, что описание дисперсионного транспорта ионов H+ на основе модели многократного захвата позволяет количественно описать кинетику образования поверхностных состояний в МОП-структурах после ионизирующего облучения. Проведено моделирование временных зависимостей плотности поверхностных состояний от толщины подзатворного диэлектрика, напряженности и полярности электрического поля. Показано, что кинетика образования поверхностных состояний определяется уровнями локализованных состояний ионов водорода в диапазоне 0.76-0.98 эВ, концентрацией ловушек как в объeме, так и в приграничной к подложке области SiO2 и зависит от начального распределения ионов H+. Ключевые слова: дисперсионный транспорт, МОП-структура, ионизирующее облучение, поверхностные состояния, моделирование.
Влияние ультрафиолетового излучения и электрического поля на проводимость структур на основе alpha- и ε-Ga-=SUB=-2-=/SUB=-O-=SUB=-3-=/SUB=-
Authors: Калыгина В.М. , Николаев В.И. , Алмаев А.В. , Цымбалов А.В. , Копьев В.В. , Петрова Ю.С. , Печников И.А. , Бутенко П.Н.
Published: July 2020

The influence of ultraviolet radiation and a strong electric field on the current-voltage characteristic of resistive structures based on polymorphic films of gallium oxide is studied. Both types of Ga2O3 films were obtained by the method of chloride vapor-phase epitaxy on smooth and structured sapphire substrates with orientation (0001). In the same process α-Ga2O3 films were deposited on smooth substrates, and gallium oxide films, with regular structures perpendicular to the substrate, containing alternating regions of the
α- and ε-phases were deposited on patterned substrate.
It’s was observed, that radiation with λ = 254 nm and strong electric transfer structures from a state with low resistance to a state with high resistance. The response time to UV radiation is 5 seconds, and the recovery time less than 1 s.
Структура, оптические и фотоэлектрические свойства пленок сульфида свинца, легированных стронцием и барием
Authors: Маскаева Л.Н. , Мостовщикова Е.В. , Воронин В.И. , Лекомцева Е.Э. , Богатова П.С. , Марков В.Ф.
Published: July 2020

The morphological evolution of composition, structural characteristics (lattice constant, microdeformations, texturing), optical and photoelectric properties of PbS films obtained by
chemical bath deposition in the presence of ammonium iodide and strontium/barium chlorides at a concentration range up to 5 mmol/l was studied. According to elemental EDX analysis, the
strontium content in PbS films was 0.4−0.7 at%, whereas barium concentration was beyond the determination error interval. The size of the particles forming the PbS films ranged from ~ 200
to ~ 400 nm with monomodal particle size distribution. The introduction of NH4I and SrCl2/BaCl2 into the bath retained the cubic B1 structure of PbS films, but led to a nonmonotonic change
in the lattice parameter, which was associated with the defects, namely, vacancies or interstitial ions. The introduction of strontium and barium salts had no effect on the PbS band gap, but led to
a change in the intensities of the impurity absorption bands in the depth and near the bottom of the conduction band. The dependence of the volt−watt sensitivity of the PbS films upon the concentration of strontium/barium in the solution was extreme with maxima at 0.05 and 0.1 mmol/l, respectively.
Структура и оптические свойства халькогенидного стеклообразного полупроводника As-Ge-Te
Authors: Исаев А.И. , Мамедова Х.И. , Мехтиева С.И. , Алекберов Р.И.
Published: July 2020

Методами рентгеноструктурного анализа, рамановской спектроскопии, измерением оптического пропускания и плотности исследованы структура и оптические свойства пленки халькогенидного стеклообразного полупроводника As-Ge-Te. Определены основные структурные элементы и химические связи, образующие аморфную матрицу, а также оптическая ширина запрещенной зоны. Полученные результаты объяснены с учетом основных принципов химического упорядочения и параметров ближнего порядка в расположении атомов. Ключевые слова: координационные числа, когезионная энергия, плотности упаковки, компактности.
Емкостная спектроскопия гетероэпитакиальных AlGaAs/GaAs p-i-n-структур
Authors: Соболев М.М. , Солдатенков Ф.Ю.
Published: July 2020

Temperature dependences of capacitance-voltage (C−V) characteristics and deep-level spectra of the graded highvoltage AlxGa1−xAs p0 −i−n0 junction grown by liquid-phase epitaxy via autodoping with background impurities were investigated. The changes of the C−V characteristics at varied measurement
temperature and optical illumination demonstrated that the p0-, i-,n0-type layers in the AlxGa1−xAs under study contain bistable DX centers. In spectra of deep-level transient spectroscopy (DLTS),
measured at various bias voltages Vr and filling pulses Vf , a positive DLTS peak is observed for the n
0 -type layer with thermal activation energy Et = 280 meV and electron-capture cross-section
σn = 3.17 · 10−14 cm2, which is unusual for a majority-carrier trap. This peak is related to the negatively charged state of the Se/Te donor impurity, which is a bistable DX center with negative
correlation energy U.