bluuebunny/crossref_metadata_2025 huggingface dataset:
Microstructural Feature and Magnetocaloric Effect of Mn50Ni40.5In9.5 Melt-Spun Ribbons
Authors: Yang Yiqiao , Li Zongbin , Li Zhenzhuang , Yang Jiajing , Yang Bo , Dong Yu , Yan Haile , Zhang Yudong , Esling Claude , Zhao Xiang , Zuo Liang
Published: September 2017

The microstructure and magnetocaloric properties of the melt-spun and annealed Mn50Ni40.5In9.5 ribbons were studied. It is shown that the post-annealing results in a considerable increase of the grain size for the initial austenite, where the columnar-shaped austenite grains almost run through the whole ribbon. Both the melt-spun and annealed ribbons consist of the mixture of austenite and martensite at room temperature, where a 8-layered modulated (8M) martensite structure was identified through selected area electron diffraction (SAED). Further High-angle Annular Dark-field (HAADF) characterizations reveal that the modulation period of 8M martensite is not homogeneous in one martensite plate. Due to strong magneto-structural coupling, the inverse martensitic transformation from a weak magnetic martensite to a strong magnetic austenite can be induced by the magnetic field, resulting in the inverse magnetocaloric effect around room temperature. For a field change of 5 T, the magnetic entropy change ΔSM of 3.7 J·kg−1·K−1 and 6.1 J·kg−1·K−1, and the effective refrigerant capacity RCeff of 52.91 J·kg−1 and 99.08 J·kg−1 were obtained for melt-spun and annealed ribbons, respectively. The improvement of the magnetocaloric properties after annealing should be attributed to the enhanced atomic ordering and magnetization difference between two phases, as well as the reduced hysteresis loss. In addition, both the melt-spun and annealed ribbons can work at a relatively wide temperature range, i.e., δTFWHM = 34 K for melt-spun ribbons and δTFWHM = 28 K for annealed ribbons.
Through-Wall Single and Multiple Target Imaging Using MIMO Radar
Authors: Narayanan Ram , Gebhardt Evan , Broderick Sean
Published: September 2017

The ability to perform target detection through walls and barriers is important for law enforcement, homeland security, and search and rescue teams. Multiple-input-multiple-output (MIMO) radar provides an improvement over traditional phased array radars for through-wall imaging. By transmitting independent waveforms from a transmit array to a receive array, an effective virtual array is created. This array has improved degrees of freedom over phased arrays and mono-static MIMO systems. This virtual array allows us to achieve the same effective aperture length as a phased array with a lower number of elements because the virtual array can be described as the convolution of transmit and receive array positions. In addition, data from multiple walls of the same room can be used to collect target information. If two walls are perpendicular to each other and the geometry of transmit and receive arrays is known, then data can be processed independently of each other. Since the geometry of the arrays is known, a target scene can be created where the two data sets overlap. The overlapped scene can then be processed so that image artifacts that do not correlate between the data sets can be excised. The result gives improved target detection, reduction in false alarms, robustness to noise, and robustness against errors such as improperly aligned antennas. This paper explores MIMO radar techniques for target detection and localization behind building walls and addresses different mitigation techniques, such as a singular value decomposition of wavelet transform method to improve localization and detection of targets. Together, these techniques demonstrate methods that show a reduction in size and complexity of traditional through-wall radar systems while still providing accurate detection and localization. The use of the range migration algorithm in single and multi-target scenarios is shown to provide adequate imaging of through the wall targets in near and far field. Also, a multi-view algorithm is used to provide improved target detection and localization by fusing together multiple wall views.
Proactive Redundant Data Filtering Scheme for Combined RFID and Sensor Networks
Authors: Ouadou Mourad , Zytoune Ouadoudi
Published: September 2017

Radio Frequency Identification (RFID) is gaining significant thrust in many application fields such as identification and real-time localization systems. Consequently, nowadays, the demand for integrated RFID-Sensors networks is increasing. Usually, numerous RFID-Sensors are deployed to form such types of networks. Then, an RFID tag can be located in the reading field of more than one reader that generates duplicated data reception at the base station. The data redundancy transmission causes unnecessary energy consumption and network overloading that contributes to the augmentation of transmission delays. In this paper, we tackle the data duplication reception problem. We propose an efficient and proactive filtering scheme for redundant data based on a preliminary broadcast. Our scheme allows us to prevent and significantly reduce the redundant data and improve the performances of the integrated RFID-sensor network.
Wind Power Ramps Driven by Windstorms and Cyclones
Authors: Lacerda Madalena , Couto António , Estanqueiro Ana
Published: September 2017

The increase in the wind power predictability assumes a very important role for secure power system operation at minimum costs, especially in situations with severe changes in wind power production. In order to improve the forecast of such events, also known as “wind power ramp events”, the underlying role of some severe meteorological phenomena in triggering wind power ramps must be clearly understood. In this paper, windstorm and cyclone detection algorithms are implemented using historical reanalysis data allowing the identification of key characteristics (e.g., location, intensity and trajectories) of the events with the highest impact on the wind power ramp events in Portugal. The results show a strong association between cyclones/windstorms and wind power ramp events. Moreover, the results highlight that it is possible to use some features of these meteorological phenomena to detect, in an early stage, severe wind power ramps thus creating the possibility to develop operational decision tools in order to support the security of power systems with high amounts of wind power generation.
Application of a Simplified Thermal-Electric Model of a Sodium-Nickel Chloride Battery Energy Storage System to a Real Case Residential Prosumer
Authors: Bignucolo Fabio , Coppo Massimiliano , Crugnola Giorgio , Savio Andrea
Published: September 2017

Recently, power system customers have changed the way they interact with public networks, playing a more and more active role. End-users first installed local small-size generating units, and now they are being equipped with storage devices to increase the selfconsumption rate. By suitably managing local resources, the provision of ancillary services and aggregations among several end-users are expected evolutions in the near future. In the upcoming market of household-sized storage devices, sodium-nickel chloride technology seems to be an interesting alternative to lead-acid and lithium-ion batteries. To accurately investigate the operation of the NaNiCl2 battery system at the residential level, a suitable thermoelectric model has been developed by the authors, starting from the results of laboratory tests. The behavior of the battery internal temperature has been characterized. Then, the designed model has been used to evaluate the economic profitability in installing a storage system in the case that end-users are already equipped with a photovoltaic unit. To obtain realistic results, real field measurements of customer consumption and solar radiation have been considered. A concrete interest in adopting the sodiumnickel chloride technology at the residential level is confirmed, taking into account the achievable benefits in terms of economic income, back-up supply, and increased indifference to the evolution of the electricity market.
Analytical Derivation of Electrical-Side Maximum Power Line for Wind Generators
Authors: Kolesnik Sergei , Kuperman Alon
Published: September 2017

In order to enhance the maximum power point tracking (MPPT) speed of solar generators, offline calculated maximum power line (MPL) is often used as a feed-forward signal added to the output of MPPT controller. MPL is nonlinear static electrical characteristic of renewable energy generators connecting all the maximum power points for given temperature. In this letter, electrical side MPL is derived for a typical wind turbine generator (WTG). It is shown that MPLs of solar and wind generators possess similar structure, supporting the similarity between the two energy conversion processes.
Applicability of a Freundlich-Like Model for Plant Uptake at an Industrial Contaminated Site with a High Variable Arsenic Concentration
Authors: Pedron Francesca , Grifoni Martina , Barbafieri Meri , Petruzzelli Gianniantonio , Rosellini Irene , Franchi Elisabetta , Bagatin Roberto , Vocciante Marco
Published: September 2017

Phytoextraction is a low-cost technology with negligible environmental impacts. A major issue at the field scale is the heterogeneity of contaminant concentration since the entire site needs to be treated evenly even though zones may need different incisiveness in the treatment. The concentration ratio (Cshoot/Csoil) is generally used to evaluate plant species performance and it includes for simplicity an assumption of linearity in the uptake behavior, although deviation from linearity has been observed in several studies. This work describes a phytoextraction feasibility test, conducted at a greenhouse scale for the remediation of an arsenic-contaminated site. Since a feasibility test should also provide an uptake model that accounts for plant growth in heterogeneous areas, the investigation focused on defining the uptake behavior of the various selected species growing in a site with homogeneous soil properties, but with considerable differences in arsenic concentration. Among the many models selectable to describe the soil-to-plant transfer, the Freundlich-like approach was tested. While remaining easy to handle, the non-linear model selected proves to be adequate to predict the arsenic uptake despite the complex contamination considered, thus allowing a more realistic prediction of the potential of a field-scale phytoremediation procedure.
Nonlinear Variations of Net Primary Productivity and Its Relationship with Climate and Vegetation Phenology, China
Authors: Yang Jian , Zhang Xin , Luo Zhao , Yu Xi
Published: September 2017

Net primary productivity (NPP) is an important component of the terrestrial carbon cycle. In this study, NPP was estimated based on two models and Moderate Resolution Imaging Spaectroradiometer (MODIS) data. The spatiotemporal patterns of NPP and the correlations with climate factors and vegetation phenology were then analyzed. Our results showed that NPP derived from MODIS performed well in China. Spatially, NPP decreased from the southeast toward the northwest. Temporally, NPP showed a nonlinear increasing trend at a national scale, but the magnitude became slow after 2004. At a regional scale, NPP in Northern China and the Tibetan Plateau showed a nonlinear increasing trend, while the NPP decreased in most areas of Southern China. The decreases in NPP were more than offset by the increases. At the biome level, all vegetation types displayed an increasing trend, except for shrub and evergreen broad forests (EBF). Moreover, a turning point year occurred for all vegetation types, except for EBF. Generally, climatic factors and Length of Season were all positively correlated with the NPP, while the relationships were much more diverse at a regional level. The direct effect of solar radiation on the NPP was larger (0.31) than precipitation (0.25) and temperature (0.07). Our results indicated that China could mitigate climate warming at a regional and/or global scale to some extent during the time period of 2001–2014.
Usability of a Medication Event Reminder Monitor System (MERM) by Providers and Patients to Improve Adherence in the Management of Tuberculosis
Authors: Liu Xiaoqiu , Blaschke Terrence , Thomas Bruce , De Geest Sabina , Jiang Shiwen , Gao Yongxin , Li Xinxu , Buono Elizabeth , Buchanan Stacy , Zhang Zhiying , Huan Shitong
Published: September 2017

Poor initiation and implementation and premature discontinuation of anti-tuberculous therapy, all forms of nonadherence, are major reasons for treatment failure, the development of drug-resistant tuberculosis, and transmission to other non-infected individuals. Directly Observed Therapy (DOT) has been the worldwide standard, but implementation of DOT is burdensome for providers and patients, especially in resource-limited settings, where most of the burden of active TB is located. Among the alternatives to DOT is electronic monitoring (EM) of drug dosing histories. Here we report a usability study of a newly-designed, modular electronic monitor product, called the MERM (Medication Event and Reminder Monitor), that is compatible with TB medication formats and supply chains in resource-limited settings. This study, done in a rural setting in China, showed that the use of the MERM for EM of TB medications was associated with a high degree of user performance, acceptability, and satisfaction among both TB patients and medical staff. Based on these data, EM is becoming the standard of care for drug-susceptible TB patients in China and scaled implementations in several other countries with high TB burden have begun. In addition, the MERM is being used in MDR-TB patients and in clinical trials involving patients with TB/HIV and latent TB.
How Does Patient Safety Culture in the Surgical Departments Compare to the Rest of the County Hospitals in Xiaogan City of China?
Authors: Wang Manli , Tao Hongbing
Published: September 2017

Objectives: Patient safety culture affects patient safety and the performance of hospitals. The Hospital Survey on Patient Safety Culture (HSOPSC) is generally used to assess the safety culture in hospitals and unit levels. However, only a few studies in China have measured surgical settings compared with other units in county hospitals using the HSOPSC. This study aims to assess the strengths and weaknesses of surgical departments compared with all other departments in county hospitals in China with HSOPSC. Design: This research is a cross-sectional study. Methods: In 2015, a Chinese translation of HSOPSC was administered to 1379 staff from sampled departments from 19 county hospitals in Xiaogan City (Hubei Province, China) using a simple random and cluster sampling method. Outcome Measures: The HSOPSC was completed by 1379 participants. The percent positive ratings (PPRs) of 12 dimensions (i.e., teamwork within units, organizational learning and continuous improvement, staffing, non-punitive response to errors, supervisor/ manager expectations and actions promoting patient safety, feedback and communication about errors, communication openness, hospital handoffs and transitions, teamwork across hospital units, hospital management support for patient safety, overall perception of safety, as well as frequency of events reported) and the positive proportion of outcome variables (patient safety grade and number of events reported) between surgical departments and other departments were compared with t-tests and X2 tests, respectively. A multiple regression analysis was conducted, with the outcome dimensions serving as dependent variables and basic characteristics and other dimensions serving as independent variables. Similarly, ordinal logistic regression was used to explore the influencing factors of two categorical outcomes. Results: A total of 56.49% of respondents were from surgical departments. The PPRs for “teamwork within units” and “organizational learning and continuous improvement” were ≥75%, which denoted strengths, and the PPRs for “staffing” and “non-punitive response to errors” were ≤50%, which denoted weaknesses in surgical units and other units. Three dimensions for surgical departments were weaker than those for other departments (p < 0.05). The staff from surgical units reported more events compared with the other units, but only a few respondents in surgical settings evaluated patient safety grade as good/excellent. Four dimensions influenced patient safety grade, and three dimensions influenced event reporting in surgical units. Conclusions: Strategies including recruiting workers, using the reporting system, and building a non-punitive culture should be adopted in the surgical units of county hospitals in China to improve safety culture. Supervisors should also prioritise patient safety.
Prevalence and Correlates of Physical Inactivity during Leisure-Time and Commuting among Beneficiaries of Government Welfare Assistance in Poland
Authors: Kaleta Dorota , Kalucka Sylwia , Szatko Franciszek , Makowiec-Dąbrowska Teresa
Published: September 2017

Physical activity (PA) has well-documented health benefits helping to prevent development of non-communicable diseases. The aim of the study was to examine the prevalence and factors associated with physical inactivity during leisure-time (LTPA) and commuting (CPA) among adult social assistance beneficiaries in Piotrkowski district. The studied sample consisted of 1817 respondents. Over 73% of the study population did not meet the recommended levels of LTPA. Fifty two % of the respondents had none leisure-time physical activity and 21.5% exercised occasionally. Main reasons for not taking up LTPA included: high general physical activity (36.4%), lack of time (28.1%), no willingness to exercise (25.4%). Close to 82% of the surveyed population did not practice commuting physical activity (CPA). The men had higher risk for inactivity during LTPA compared to the women (OR = 1.35; 95% CI: 1.11–1.65; p ≤ 0.05). Higher odds of CPA inactivity were associated with unemployment, moderate and heavy drinking and having a number of health problems. The prevalence of physical inactivity among the social assistance recipients is much higher than it is in the general population. Promotion of an active lifestyle should take into consideration substantial differences between the general population and disadvantaged individuals and their various needs.
Socioeconomic Inequalities in Health and Perceived Unmet Needs for Healthcare among the Elderly in Germany
Authors: Hoebel Jens , Rommel Alexander , Schröder Sara , Fuchs Judith , Nowossadeck Enno , Lampert Thomas
Published: September 2017

Research into health inequalities in the elderly population of Germany is relatively scarce. This study examines socioeconomic inequalities in health and perceived unmet needs for healthcare and explores the dynamics of health inequalities with age among elderly people in Germany. Data were derived from the Robert Koch Institute’s cross-sectional German Health Update study. The sample was restricted to participants aged 50–85 years (n = 11,811). Socioeconomic status (SES) was measured based on education, (former) occupation, and income. Odds ratios and prevalence differences were estimated using logistic regression and linear probability models, respectively. Our results show that self-reported health problems were more prevalent among men and women with lower SES. The extent of SES-related health inequalities decreased at older ages, predominantly among men. Although the prevalence of perceived unmet needs for healthcare was low overall, low SES was associated with higher perceptions of unmet needs in both sexes and for several kinds of health services. In conclusion, socioeconomic inequalities in health exist in a late working age and early retirement but may narrow at older ages, particularly among men. Socially disadvantaged elderly people perceive greater barriers to accessing healthcare services than those who are better off.
Mapping Changes in Carbon Storage and Productivity Services Provided by Riparian Ecosystems of Semi-Arid Environments in Northwestern Mexico
Authors: Mendez-Estrella Romeo , Romo-Leon Jose , Castellanos Alejandro
Published: September 2017

We analyze the importance of riparian ecosystems (RE) as critical areas for carbon storage and productivity in semi-arid regions of Northwest Mexico. We calculated the carbon storage by land cover and compared temporal trends of basal productivity (MODIS) and pre-monsoon productivity (Landsat) of RE, to other land cover types. We used land cover maps generated previously for the region (years 1993, 2002, and 2011), assigning values of carbon stored in aerial and root biomass, as well as organic carbon stored in the soil. To estimate productivity (proxy), time series were generated using the Normalized Difference Vegetation Index (NDVI) values of Landsat 4–5 TM and MODIS for each land cover type. We found that RE stores 93,147 tC/ha, about 1.5 times the estimated storage for oak forest (65,048 tC/ha). Productivity of RE was similar to highly productive land cover types, such as agriculture and oak forest, and higher than in the rest of the ecosystems of the region. We also found that changes from RE to agriculture and cultivated grasslands represented a decrease in productivity (p < 0.001). Finally, we report a gradual decrease in basal productivity (p = 0.0151) and pre-monsoon productivity (p = 0.031) in the RE. These results help us understand that changes in land use, intensive use of water, and climate can influence the ecosystem services of productivity and carbon storage offered by RE in semi-arid areas.
Podocalyxin-Like Protein 1 Regulates TAZ Signaling and Stemness Properties in Colon Cancer
Authors: Lee Wen-Ying , Kuo Chih-Chia , Lin Bo-Xing , Cheng Chia-Hsiung , Chen Ku-Chung , Lin Cheng-Wei
Published: September 2017

Colon cancer is the third most common cancer in the world and the second most common cause of cancer-related mortality. Molecular biomarkers for colon cancer have undergone vigorous discovery and validation. Recent studies reported that overexpression of podocalyxin-like protein 1 (PODXL) is associated with distant metastasis and poor prognosis across several types of malignancies. Its role and underlying molecular mechanism, however, are not yet fully understood. In the present study, we revealed that the Hippo transducer, the transcriptional coactivator with PDZ-binding motif (TAZ), acts as a downstream mediator of PODXL in colon cancer. Inhibition of PODXL resulted in the suppression of TAZ signaling and the downregulation of Hippo downstream genes. Moreover, PODXL plays a critical role in cancer stemness, invasiveness, and sensitivity to chemotherapies in colon cancer HCT15 cells. Notably, expression of PODXL showed a positive correlation with stem-like and epithelial-mesenchymal transition (EMT) core signatures, and was associated with poor survival outcomes in patients with colon cancer. These findings provide novel insights into the molecular mechanism of PODXL-mediated tumorigenesis in colon cancer.
E-Learning for Rare Diseases: An Example Using Fabry Disease
Authors: Cimmaruta Chiara , Liguori Ludovica , Monticelli Maria , Andreotti Giuseppina , Citro Valentina
Published: September 2017

Background: Rare diseases represent a challenge for physicians because patients are rarely seen, and they can manifest with symptoms similar to those of common diseases. In this work, genetic confirmation of diagnosis is derived from DNA sequencing. We present a tutorial for the molecular analysis of a rare disease using Fabry disease as an example. Methods: An exonic sequence derived from a hypothetical male patient was matched against human reference data using a genome browser. The missense mutation was identified by running BlastX, and information on the affected protein was retrieved from the database UniProt. The pathogenic nature of the mutation was assessed with PolyPhen-2. Disease-specific databases were used to assess whether the missense mutation led to a severe phenotype, and whether pharmacological therapy was an option. Results: An inexpensive bioinformatics approach is presented to get the reader acquainted with the diagnosis of Fabry disease. The reader is introduced to the field of pharmacological chaperones, a therapeutic approach that can be applied only to certain Fabry genotypes. Conclusion: The principle underlying the analysis of exome sequencing can be explained in simple terms using web applications and databases which facilitate diagnosis and therapeutic choices.
Evaluating Changes in Cell-Wall Components Associated with Clubroot Resistance Using Fourier Transform Infrared Spectroscopy and RT-PCR
Authors: Lahlali Rachid , Song Tao , Chu Mingguang , Yu Fengqun , Kumar Saroj , Karunakaran Chithra , Peng Gary
Published: September 2017

Clubroot disease is a serious threat to canola production in western Canada and many parts of the world. Rcr1 is a clubroot resistance (CR) gene identified recently and its molecular mechanisms in mediating CR have been studied using several omics approaches. The current study aimed to characterize the biochemical changes in the cell wall of canola roots connecting to key molecular mechanisms of this CR gene identified in prior studies using Fourier transform infrared (FTIR) spectroscopy. The expression of nine genes involved in phenylpropanoid metabolism was also studied using qPCR. Between susceptible (S) and resistance (R) samples, the most notable biochemical changes were related to an increased biosynthesis of lignin and phenolics. These results were supported by the transcription data on higher expression of BrPAL1. The up-regulation of PAL is indicative of an inducible defence response conferred by Rcr1; the activation of this basal defence gene via the phenylpropanoid pathway may contribute to clubroot resistance conferred by Rcr1. The data indicate that several cell-wall components, including lignin and pectin, may play a role in defence responses against clubroot. Principal components analysis of FTIR data separated non-inoculated samples from inoculated samples, but not so much between inoculated S and inoculated R samples. It is also shown that FTIR spectroscopy can be a useful tool in studying plant-pathogen interaction at cellular levels.
Mitochondriotropic and Cardioprotective Effects of Triphenylphosphonium-Conjugated Derivatives of the Diterpenoid Isosteviol
Authors: Testai Lara , Strobykina Irina , Semenov Victor V. , Semenova Marina , Pozzo Eleonora Da , Martelli Alma , Citi Valentina , Martini Claudia , Breschi Maria C. , Kataev Vladimir E. , Calderone Vincenzo
Published: September 2017

Mitochondria play a crucial role in the cell fate; in particular, reducing the accumulation of calcium in the mitochondrial matrix offers cardioprotection. This affect is achieved by a mild depolarization of the mitochondrial membrane potential, which prevents the assembly and opening of the mitochondrial permeability transition pore. For this reason, mitochondria are an attractive target for pharmacological interventions that prevent ischaemia/reperfusion injury. Isosteviol is a diterpenoid created from the acid hydrolysis of Stevia rebaudiana Bertoni (fam. Asteraceae) glycosides that has shown protective effects against ischaemia/reperfusion injury, which are likely mediated through the activation of mitochondrial adenosine tri-phosphate (ATP)-sensitive potassium (mitoKATP) channels. Some triphenylphosphonium (triPP)-conjugated derivatives of isosteviol have been developed, and to evaluate the possible pharmacological benefits that result from these synthetic modifications, in this study, the mitochondriotropic properties of isosteviol and several triPP-conjugates were investigated in rat cardiac mitochondria and in the rat heart cell line H9c2. This study’s main findings highlight the ability of isosteviol to depolarize the mitochondrial membrane potential and reduce calcium uptake by the mitochondria, which are typical functions of mitochondrial potassium channel openings. Moreover, triPP-conjugated derivatives showed a similar behavior to isosteviol but at lower concentrations, indicative of their improved uptake into the mitochondrial matrix. Finally, the cardioprotective property of a selected triPP-conjugated derivative was demonstrated in an in vivo model of acute myocardial infarct.
History and Outcome of Febrile Neutropenia Outside the Oncology Setting: A Retrospective Study of 76 Cases Related to Non-Chemotherapy Drugs
Authors: Andrès Emmanuel , Mourot-Cottet Rachel , Maloisel Frédéric , Keller Olivier , Vogel Thomas , Séverac François , Tebacher Martine , Gottenberg Jacques-Eric , Weber Jean-Christophe , Kaltenbach Georges , Goichot Bernard , Sibilia Jean , Korganow Anne-Sophie , Herbrecht Raoul
Published: September 2017

Background: Despite major advances in its prevention and treatment, febrile neutropenia remains a most concerning complication of cancer chemotherapy. Outside the oncology setting, however, only few data are currently available on febrile neutropenia related to non-chemotherapy drugs. We report here data on 76 patients with febrile neutropenia related to non-chemotherapy drugs, followed up in a referral center within a university hospital. Patients and methods: Data from 76 patients with idiosyncratic drug-induced febrile neutropenia were retrospectively reviewed. All cases were extracted from a cohort study on agranulocytosis conducted at the Strasbourg University Hospital (Strasbourg, France). Results: Mean patient age was 52.2 years old (range: 18–93) and gender ratio (F/M) 1.6, with several comorbidities present in 86.8% of patients. The most common causative drugs were: antibiotics (37.4%), antithyroid drugs (17.2%), neuroleptic and anti-epileptic agents (13.1%), non-steroidal anti-inflammatory agents and analgesics (8%), and platelet aggregation inhibitors (8%). Main clinical presentations upon hospitalization included isolated fever (30%), sore throat, acute tonsillitis and sinusitis (18.4%), documented pneumonia (18.4%), septicemia (14.5%), and septic shock (6.6%). Mean neutrophil count at nadir was 0.13 × 10(9)/L (range: 0–0.48). While in hospital, 22 patients (28.9%) worsened clinically and required intensive care unit placement. All patients were promptly treated with broad-spectrum antibiotics, and 45 (59.2%) with hematopoietic growth factors. Mean duration of hematological recovery (neutrophil count ≥1.5 × 10(9)/L) was 7.5 days (range: 2–21), which was reduced to 0.7 days (range: 2–16) (p = 0.089) with hematopoietic growth factors. Outcome was favorable in 89.5% of patients, whereas eight died. Conclusions: Like in oncology and myelosuppressive chemotherapy settings, idiosyncratic febrile neutropenia is typically serious, about 40% of patients exhibiting severe pneumonia, septicemia, and septic shock, with a mortality rate of 10%. Like in febrile, chemotherapy-related neutropenia, modern and timely management (immediate broad spectrum antibiotherapy, hematopoietic growth factors) may reduce infection-related mortality. All practitioners should be aware of this potential side-effect that may even occur in the event of “daily medication” exposure.
Exercise Training as Treatment of Nonalcoholic Fatty Liver Disease
Authors: Glass Oliver , Radia Akash , Kraus William , Abdelmalek Manal
Published: September 2017

Nonalcoholic Fatty Liver Disease (NAFLD) is a growing health epidemic in developed countries with increased prevalence in obese and diabetic populations. Exercise is an established and essential component of lifestyle modification for NAFLD disease management. Despite numerous studies reporting exercise-mediated improvements in NAFLD, there remains a large gap in our knowledge of how to optimize exercise prescriptions and whether the benefits of exercise extend beyond improvements in liver fat. In this review, we summarize studies that have investigated the independent effects of exercise training on liver enzymes, hepatic fat, and histologic markers in NAFLD. Overall, 12-weeks of aerobic, resistance, the combination of aerobic and resistance, and novel training modalities, including acceleration and hybrid training, significantly improve liver enzymes and hepatic fat. The greatest benefits in NAFLD may occur through the combination of aerobic and resistance training that targets both cardiorespiratory fitness, and mediators of skeletal muscle, known as myokines. Understanding the role of myokines in the beneficial effects of exercise in NAFLD may identify future therapeutic targets that can be modified with tailored exercise prescriptions.
Enhanced Growth of ZDDP-Based Tribofilms on Laser-Interference Patterned Cylinder Roller Bearings
Authors: Hsu Chia-Jui , Stratmann Andreas , Rosenkranz Andreas , Gachot Carsten
Published: September 2017

Laser surface texturing has been successfully applied in the past to various machine elements in order to improve their tribological performance. In this study, direct laser interference patterning was used to produce periodic cross-like surface patterns on commercial cylinder roller bearings. The wear behavior of as-patterned bearings was studied by a modified FE8 test rig under boundary lubrication. A mineral oil (ISO VG 100) as a base oil additivated with 0.02 wt % zinc dialkyldithiophosphate (ZDDP) was used for the tribological tests which were performed under a Hertzian pressure of 1.92 GPa and maintained at 80 °C and 20 rpm for 2 h. The laser-patterned bearings showed a significantly reduced mass loss by two orders of magnitude compared to the unpatterned reference bearings. A closer look at the samples proved the formation of the characteristic blue-colored ZDDP tribofilm on top of the laser-induced topography maximum positions. Due to the higher contact pressure at the laser-induced peaks, the tribofilm formation was preferable at those positions thus protecting against wear. The laser patterns nearly remained unworn compared to the reference samples. A subsequent Raman analysis of the laser-patterned bearings clearly revealed the formation of zinc and iron sulfides as well as phosphates at the peak points.
Investigation of the Microstructure Evolution in a Fe-17Mn-1.5Al-0.3C Steel via In Situ Synchrotron X-ray Diffraction during a Tensile Test
Authors: Ma Yan , Song Wenwen , Bleck Wolfgang
Published: September 2017

The quantitative characterization of the microstructure evolution in high-Mn steel during deformation is of great importance to understanding its strain-hardening behavior. In the current study, in situ high-energy synchrotron X-ray diffraction was employed to characterize the microstructure evolution in a Fe-17Mn-1.5Al-0.3C steel during a tensile test. The microstructure at different engineering strain levels—in terms of ε-martensite and α’-martensite volume fractions, the stacking fault probability, and the twin fault probability—was analyzed by the Rietveld refinement method. The Fe-17Mn-1.5Al-0.3C steel exhibits a high ultimate tensile strength with a superior uniform elongation and a high strain-hardening rate. The remaining high strain-hardening rate at the strain level about 0.025 to 0.35 results from ε-martensite dominant transformation-induced-plasticity (TRIP) effect. The increase in the strain-hardening rate at the strain level around 0.35 to 0.43 is attributed to the synergetic α’-martensite dominant TRIP and twinning-induced-plasticity (TWIP) effects. An evaluation of the stacking fault energy (SFE) of the Fe-17Mn-1.5Al-0.3C steel by the synchrotron measurements shows good agreement with the thermodynamic calculation of the SFE.
Impedance Spectroscopy Study of the Effect of Environmental Conditions on the Microstructure Development of Sustainable Fly Ash Cement Mortars
Authors: Ortega José , Sánchez Isidro , Climent Miguel
Published: September 2017

Today, the characterisation of the microstructure of cement-based materials using non-destructive techniques has become an important topic of study, and among them, the impedance spectroscopy has recently experienced great progress. In this research, mortars with two different contents of fly ash were exposed to four different constant temperature and relative humidity environments during a 180-day period. The evolution of their microstructure was studied using impedance spectroscopy, whose results were contrasted with mercury intrusion porosimetry. The hardening environment has an influence on the microstructure of fly ash cement mortars. On one hand, the impedance resistances R1 and R2 are more influenced by the drying of the materials than by microstructure development, so they are not suitable for following the evolution of the porous network under non-optimum conditions. On the other hand, the impedance spectroscopy capacitances C1 and C2 allow studying the microstructure development of fly ash cement mortars exposed to those conditions, and their results are in accordance with mercury intrusion porosimetry ones. Finally, it has been observed that the combined analysis of the abovementioned capacitances could be very useful for studying shrinkage processes in cement-based materials kept in low relative humidity environments.
Electronic Energy Meter Based on a Tunnel Magnetoresistive Effect (TMR) Current Sensor
Authors: Vidal Enrique García , Muñoz Diego Ramírez , Arias Sergio Iván Ravelo , Moreno Jaime Sánchez , Cardoso Susana , Ferreira Ricardo , Freitas Paulo
Published: September 2017

In the present work, the design and microfabrication of a tunneling magnetoresistance (TMR) electrical current sensor is presented. After its physical and electrical characterization, a wattmeter is developed to determine the active power delivered to a load from the AC 50/60 Hz mains line. Experimental results are shown up to 1000 W of power load. A relative uncertainty of less than 1.5% with resistive load and less than 1% with capacitive load was obtained. The described application is an example of how TMR sensing technology can play a relevant role in the management and control of electrical energy.
The Isotropic and Cubic Material Designs. Recovery of the Underlying Microstructures Appearing in the Least Compliant Continuum Bodies
Authors: Czarnecki Sławomir , Łukasiak Tomasz , Lewiński Tomasz
Published: September 2017

The paper discusses the problem of manufacturability of the minimum compliance designs of the structural elements made of two kinds of inhomogeneous materials: the isotropic and cubic. In both the cases the unit cost of the design is assumed as equal to the trace of the Hooke tensor. The Isotropic Material Design (IMD) delivers the optimal distribution of the bulk and shear moduli within the design domain. The Cubic Material Design (CMD) leads to the optimal material orientation and optimal distribution of the invariant moduli in the body made of the material of cubic symmetry. The present paper proves that the varying underlying microstructures (i.e., the representative volume elements (RVE) constructed of one or two isotropic materials) corresponding to the optimal designs constructed by IMD and CMD methods can be recovered by matching the values of the optimal moduli with the values of the effective moduli of the RVE computed by the theory of homogenization. The CMD method leads to a larger set of results, i.e., the set of pairs of optimal moduli. Moreover, special attention is focused on proper recovery of the microstructures in the auxetic sub-domains of the optimal designs.
New Analytical Technique for Solving a System of Nonlinear Fractional Partial Differential Equations
Authors: Thabet Hayman , Kendre Subhash , Chalishajar Dimplekumar
Published: September 2017

This paper introduces a new analytical technique (NAT) for solving a system of nonlinear fractional partial differential equations (NFPDEs) in full general set. Moreover, the convergence and error analysis of the proposed technique is shown. The approximate solutions for a system of NFPDEs are easily obtained by means of Caputo fractional partial derivatives based on the properties of fractional calculus. However, analytical and numerical traveling wave solutions for some systems of nonlinear wave equations are successfully obtained to confirm the accuracy and efficiency of the proposed technique. Several numerical results are presented in the format of tables and graphs to make a comparison with results previously obtained by other well-known methods.
Structure and Formation Model of Ag/TiO2 and Au/TiO2 Nanoparticles Synthesized through Ultrasonic Spray Pyrolysis
Authors: Alkan Gözde , Rudolf Rebeka , Bogovic Jelena , Jenko Darja , Friedrich Bernd
Published: September 2017

This article explains the mechanism of the metal/oxide core-shell Ag/TiO2 and Au/TiO2 nanoparticle formation via one-step ultrasonic spray pyrolysis (USP) by establishing a new model. The general knowledge on the standard “droplet-to-particle” (DTP) mechanism, nucleation, and growth processes of noble metals, as well as physical and chemical properties of core and shell materials and experimental knowledge, were utilized with the purpose of the construction of this new model. This hypothesis was assessed on silver (Ag)/titanium oxide (TiO2) and gold (Au) TiO2 binary complex nanoparticles’ experimental findings revealed by scanning electron microscopy (SEM), focused ion beam (FIB), high-resolution transmission electron microscopy (HRTEM), and simulation of crystal lattices. It was seen that two mechanisms run as proposed in the new model. However, there were some variations in size, morphology, and distribution of Ag and Au through the TiO2 core particle and these variations could be explained by the inherent physical and chemical property differences of Ag and Au.
Overview of Intergranular Fracture of Neutron Irradiated Austenitic Stainless Steels
Authors: Hojná Anna
Published: September 2017

Austenitic stainless steels are normally ductile and exhibit deep dimples on fracture surfaces. These steels can, however, exhibit brittle intergranular fracture under some circumstances. The occurrence of intergranular fracture in the irradiated steels is briefly reviewed based on limited literature data. The data are sorted according to the irradiation temperature. Intergranular fracture may occur in association with a high irradiation temperature and void swelling. At low irradiation temperature, the steels can exhibit intergranular fracture at low or even at room temperatures during loading in air and in high temperature water (~300 °C). This paper deals with the similarities and differences for IG fractures and discusses the mechanisms involved. The intergranular fracture occurrence at low temperatures might be correlated with decohesion or twinning and strain martensite transformation in local narrow areas around grain boundaries. The possibility of a ductile-to-brittle transition is also discussed. In case of void swelling higher than 3%, quasi-cleavage at low temperature might be expected as a consequence of ductile-to-brittle fracture changes with temperature. Any existence of the change in fracture behavior in the steels of present thermal reactor internals with increasing irradiation dose should be clearly proven or disproven. Further studies to clarify the mechanism are recommended.
Heap Leaching of Caliche Ore. Modeling of a Multicomponent System with Particle Size Distribution
Authors: Ordóñez Javier , Condori Alicia , Moreno Luis , Cisternas Luis
Published: September 2017

Caliche is a mineral exploited in northern Chile, from which iodine and Nitrate salts (saltpeter) are obtained. This ore is the most important source of iodine in the world and is processed mainly by heap leaching using water as a leaching agent. Heap leaching of caliche ore is carried out by the stacking of ROM (Run-Of-Mine) material, where the particle size distribution covers a wide range, from a few millimeters up to several decimeters, even diameters about 1 m. During the leaching, the multiple soluble species of caliche, which can reach total fractions larger than 40%, are dissolved at different rates, mainly controlled by their solubilities. When it occurs and unlike most other leachable ores, the particle size diminishes. The leaching modeling of several soluble species of caliche has been recently addressed; however, one of the main assumptions is the idealization that the heap is composed of particles of the same size. The present work aims to complement the previously formulated phenomenological models for caliche ore leaching, through a model that considers the simultaneous dissolution of two species from caliche with three different particle sizes. These two water-soluble species have different solubilities and dissolution rates and the conceptual model considers that both species are dissolved at the particle surface. When the most soluble species is being depleted, the particle collapses, leaving a remaining fraction of the less soluble species together with insoluble material. The less soluble species is now being dissolved from the collapsed material. This article also includes the experimental verification of the conceptual model using data obtained from column leaching tests conducted for this purpose, focusing on the dissolution of two soluble species: Nitrate and Magnesium.
Carbon Nanohorns Modified with Conjugated Terthienyl/Terthiophene Structures: Additives to Enhance the Performance of Dye-Sensitized Solar Cells
Authors: Iglesias Daniel , Atienzar Pedro , Vázquez Ester , Herrero María , García Hermenegildo
Published: September 2017

A series of carbon nanohorns (CNHs) constituted by the aggregation of about 2000 individual conical graphene tubes (diameters from 2 nm to 5 nm and a length of 40–50 nm) that have been modified with dyes of two, three, or four terthienyl groups has been prepared by adsorbing the corresponding dye on the CNH. Persistent inks in o-dichlorobenzene (o-DCB) of these dye-CNH conjugates were obtained by laser irradiation of o-DCB suspensions of the dye-CNH solids. These inks were used in combination or not with N719 dye for the preparation of dye-sensitized solar cells (DSSC) of TiO2. It was measured that the terthienyl dye with the largest conjugation deposited on the CNH additively increased the performance of an analogous TiO2 cell from an efficiency of 4.07% to 6.24%. This result shows the potential of dye-modified CNHs as additives in the construction of more efficient DSSCs.
Validity of Nutrient Intakes Derived from an Internet Website Dish-Based Dietary Record for Self-Management of Weight among Japanese Women
Authors: Matsuzaki Eri , Michie Mikiko , Kawabata Terue
Published: September 2017

We compared the relative validity of nutrient intakes derived from Internet website dish-based dietary records (WDDRs) and weighed dietary records (DRs). The study participants were 218 registered users of a dietary management website. After excluding 55 participants, a total of 163 participants were included in the final analyses. The participants were Japanese women, and their mean age and mean body mass index (BMI) were 39.3 (±10.3) years and 22.3 (±3.7) years, respectively. We compared differences in the DR and WDDR with respect to intakes of energy and 13 nutrients. The median values for the intake of protein and seven nutrients showed no significant difference between the DR and WDDR, and the estimated values were generally similar. The interquartile range of nutrients with a significant difference did not show a large deviation, with the exception of vitamin A. Correlation coefficients showed a strong correlation of 0.7, with the exception of sodium and vitamin E. The kappa coefficients for energy and for some nutrients were good to fair. Using Bland–Altman plots, we found proportional errors in the intake values for vitamins and minerals. We could not confirm obvious systematic errors for energy, protein, fat, or carbohydrate intake. WDDR use is considered to be a valid method for estimating energy and nutrient intakes among Japanese women.