bluuebunny/crossref_metadata_2025 huggingface dataset:
Puesta en valor del sitio La Pampa como oportunidad de desarrollo del patrimonio sustentable en el Valle de Uco (Mendoza)
Authors: Rocha Andrés
Published: December 2022

Este trabajo se propone plantear las posibilidades y el potencial de la puesta en valor del sitio arqueológico La Pampa como factor de desarrollo del patrimonio sustentable en el Valle de Uco. A partir de esto, el objetivo es observar los recursos sociales y económicos del contexto local (el uso del turismo recreacional, el aprovechamiento de circuitos preexistentes, el capital humano y material, y la participación de instituciones públicas y empresas privadas) y sus posibilidades para que su puesta en valor se convierta en un vehículo del desarrollo socioeconómico, enfocándonos en el uso del sitio como espacio público, recuperando su significado local y resaltando sus potencialidades sociales, culturales y económicas. Al observar las cualidades del contexto sociocultural y económico y las características del sitio La Pampa se concluye que estos bienes patrimoniales pueden convertirse en un factor dinamizador del desarrollo local, entendiendo su valorización como un recurso que operaría como patrimonio sustentable en las comunidades donde se encuentra.
Andrés Bello en Londres: los fundamentos filológicos de la autoridad
Authors: Ennis Juan
Published: December 2022

El presente trabajo ofrece una lectura de un área precisa de los trabajos publicados por Andrés Bello en los dos proyectos editoriales más representativos desarrollados en el Londres de los 1820: la Biblioteca Americana y el Repertorio Americano, teniendo en cuenta además los materiales aportados por los recientemente publicados Cuadernos de Londres. La hipótesis de trabajo que subyace a este ejercicio es que la erudición filológica reunida en los tiempos de estudio en la biblioteca del Museo Británico, y luego escasamente desplegada en aquellos trabajos dedicados a cuestiones filológicas en ambas revistas, sienta las bases para construir una forma de tradición –más europea que española, basada en la naturalización de rasgos precisos y específicos de la lengua y la poesía– para un proyecto político que encontrará su concreción en su obra más perdurable, consagratoria e influyente desarrollada posteriormente en Chile. Dicho de otro modo, es en la aparente especificidad de estas indagaciones filológicas donde podemos comenzar a entrever los fundamentos para pensar la lengua, la nación y el poder en el autor de la Gramática y el Código Civil más influyentes en el mundo hispanohablante en el siglo XIX.
Alotropía literaria: una nueva relación transtextual
Authors: López Romero Berenice
Published: December 2022

El presente artículo presenta la hipótesis de que podría existir una nueva relación transtextual: la alotropía literaria. Esta propuesta se enmarca en el paradigma de las relaciones transtextuales de Gérard Genette. El planteamiento de la alotropía literaria surgió al identificar un fenómeno de reescritura, inicialmente, en dos parejas de textos: la novela País de nieve y el relato “Apuntes sobre País de nieve”, de Kawabata; y los cuentos “El Aleph”, de Borges, y “El Aleph engordado”, de Katchadjian. La peculiaridad de los textos en los que identificamos la reescritura es que, a pesar de mudar de forma, conservan la trama y gran cantidad de pasajes de una manera literal. Al darnos cuenta de que ni la intertextualidad ni la hipertextualidad –que son las relaciones que consideramos más cercanas a lo que entendemos por alotropía– respondían completamente al comportamiento que observamos en los textos señalados, pensamos que podría existir otra relación.
El enigma de Rimbaud y el poeta como imagen ausente en dos cuentos de Putas asesinas, de Roberto Bolaño
Authors: Schmukler Enrique
Published: December 2022

El presente artículo aborda un tema relevante de la obra del escritor chileno Roberto Bolaño: la presencia del poeta Arthur Rimbaud como un tema central de sus ficciones. Se parte de uno de los mitemas más estudiados de la obra del poeta de Charleville, el “silencio de Rimbaud”, esto es, el momento en que el poeta “s’en va”, abandona la poesía y se activa el misterio que rodeará su figura para la posteridad. Nuestro propósito es ver el funcionamiento de ese mitema en dos cuentos de Bolaño, “Últimos atardeceres en la Tierra!” y “Fotos” del libro Putas asesinas con el objetivo central de pensar la concepción autorial del propio Bolaño y el vínculo entre autor e imagen en estos textos.
Effect of Supplementation of Thyme and Turmeric Essential Oils on Hemato-biochemical Parameters of Japanese Quails
Authors: Ranwa Suman , Palod Jyoti , Sharma Rabendra K. , Kumar Shive , Abhilasha
Published: December 2022

This experiment was undertaken to assess the influence of thyme (Thymus vulgaris) and turmeric (Curcuma longa) essential oils on hematobiochemical parameters of Japanese quails. One hundred eighty, 6-day old Japanese quail chicks were subjected to five weeks trial. Quail chicks were distributed at random into five dietary treatment groups each with three replicates of 12 quails per treatment. Quails of T0 group fed diet without essential oils (Basal diet), T1 group fed basal diet with 0.2 % thyme essential oil, T2 group fed basal diet with 0.3% turmeric essential oil, T3 group fed basal diet with combination of 0.125 % thyme essential oil and 0.075 % turmeric essential oils, T4 group fed basal diet with combination of 0.075% thyme essential oil and 0.125 % turmeric essential oils. The results revealed that Japanese quails of essential oils supplemented groups had significantly higher (p<0.05) red blood cell count, packed cell volume, haemoglobin, mean corpuscular volume, mean corpuscular haemoglobin, serum protein, albumin globulin and high-density lipoprotein concentrations with best results found in T4   group. Supplementing Japanese quails with thyme and turmeric essential oils significantly lowered serum uric acid, creatinine, total bilirubin, glucose, total cholesterol, triglycerides, LDL, SGOT and SGPT activity. It can be concluded that nutritional supplementation of thyme and turmeric essential oils at 0.075 % and 0.125 % in combination improved haematological indices and most of the serum biochemical parameters in Japanese quails.
Effect of Milk Replacer on Growth Performance and Economics of Raising Preweaned HF Crossbred Calves
Authors: Jadav Prabhatsinh V. , Gaur Vinay
Published: December 2022

As compared to whole milk feeding, milk replacer is an excellent cheaper source of nutrition for calves prior to weaning. For this study, 20 newborn HF crossbred calves were divided into two equal groups each of 10 animals and were put under 8 weeks feeding trial. The calves of control group (T1) were fed cow’s whole milk as per owner’s practice in the field, while those of treatment group (T2) were fed whole milk @ 2.5 ltr during 1st week and then milk replacer (Amul brand) was fed @ 50 gm and 150 gm along with 2.0 ltr and 1.0 ltr whole milk during 2nd and 3rd week, respectively, and then only the milk replacer @ 250, 350, 450, 500 and 400 gm was used during 4th, 5th, 6th, 7th and 8th week, respectively. Weekly body weight was calculated based on measurements of heart girth and body length using Shaffer’s formula. The average body weight during 1st week of age was statistically similar in both groups. The overall mean values of gain in body weight and daily gain in weight in control and treatment groups were 20.40±0.51 vs. 24.67±0.41 kg, and 364.29±9.04 vs. 440.54±7.32 g (20.09% and 20.92% increase in T2 over T1), respectively. The weekly growth rate and overall daily gain in body weight in calves of T2 group were significantly (p<0.001) higher than in T1 group. There was 21.08 % reduction (p<0.001) in cost of feeding with milk replacer over whole milk (Rs. 3454.5 vs 4377.2) for first 8 weeks of life. In general, the crossbred calves can be raised economically on commercial milk replacer without adverse effect on their health and growth rate.
Genetic Polymorphism of Insulin-Like Growth Factor 1 and Prolactin Receptor Genes in Surti and Mehsana Goats by PCR-RFLP
Authors: Ansari Farheen , Brahmkshtri Balkrushna , Ramani Umed , Janmeda Mamta , Rao Thakur K
Published: December 2022

The present study was planned with the objective to amplify 5’NCR Insulin-like growth factor 1 (IGF1) and 3’UTR Prolactin receptor (PRLR) genes using caprine specific primers by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) in Surti and Mehsana goats. IGF1 gene 5’NCR was found to be monomorphic on restriction digestion with HaeIII, which revealed only one genotype GG in both Surti and Mehsana goats. The allele frequency of G was found to be 1.00 in both the breeds. Restriction digestion of PRLR gene 443 bp fragment with AluI also showed monomorphic pattern. Only one genotype CC was found with an allele frequency of 1.0 in both the Surti and Mehsana goats.
Dystocia due to Post-Cervical Uterine Torsion along with Foetal Ascites in a Cross-Bred Holstein-Friesian Cow
Authors: Sharma Pushkar , Mahour Sobran Singh , Parihar Atul Singh , Sankhla Sachin , Khushwah Neeraj
Published: December 2022

A twisting or rolling of the uterus along its longitudinal axis is known as uterine torsion (Roberts, 2004). Compared to other domestic animal species, bovines have a significantly higher prevalence of dystocia (Dutt et al., 2021). Uterine torsion is one of the common causes of dystocia in buffaloes than in cows (Purohit et al., 2011). In dairy cattle frequency of right horn pregnancy is reported as 60% to 68%, counterclockwise torsion would then be detected primarily in cases of right horn pregnancy (Arthur et al., 1996). Blockage of lymphatics, excessive production or inadequate drainage of peritoneal fluid and other factors can result in foetal ascites (Sloss and Duffy, 1980). Additionally, dropsical conditions of foetus such as hydrocephalus, ascites, hydrothorax, and foetal anasarca can also result in dystocia (Purohit et al., 2006; Purohit et al., 2012). The management of dystocia caused by left side post-cervical torsion and foetal ascites is described in the current case study. The patient was successfully treated without any complications
Modularization of React Data-Tables
Authors: Pranav Jadhav  , Pratapsingh Garud  , Aditya Kulkarni  , Vaibhav Kuwar  , Sanket Salunke  , Yogesh Sharma
Published: December 2022

React data table is one of the great table provision libraries out there. With more than fifty thousand downloads every week, react data table has proven it provides better functionality than the other available react table libraries. Its highly customisable features help us to bring out the most of it. It offers quick access to features like sorting, pagination, and themes. This paper will demonstrate how we can optimise and modularize this component for a custom use case. This modularized component will provide us with a setup that will be reusable over all our react pages or components. Before all that we will be going through understanding of the react-data-table functionalities. In the later parts of this paper, we will also go through props passing techniques used in the optimisations.
Detecting Spam Email With Machine Learning Optimized With Bio-Inspired Metaheuristic Algorithms
Authors: Vatan Koshti  , Aditi Gaherwar  , Twinkle Ramteke  , Yogeshwari Durgam  , Prof. Madhavi Sadu
Published: December 2022

Electronic mail has eased communication methods for many organizations as well as individuals. Spammers use this strategy to make fraudulent gains by sending unsolicited emails. This project aims to present a method for detection of spam emails with machine learning algorithms that are optimized with bio-inspired methods. A literature review is carried to explore the efficient methods applied on different datasets to achieve good results. The bio-inspired algorithms like Particle Swarm Optimization and Genetic Algorithm were implemented to optimize the performance of classifiers. Multinomial Naïve Bayes with Genetic Algorithm performed the best overall. The comparison of our results with other machine learning and bio-inspired models to show the best suitable model is also discussed.
Edificios de piedra australianos: naturaleza, degradación y conservación
Authors: Trovò Francesco
Published: December 2022

La contribución trata sobre los edificios de piedra en Melbourne y Sydney construidos a partir de la segunda mitad del siglo XIX. Se reportan los resultados de un censo relativo a aproximadamente 140 edificios, analizados según el tipo de piedra utilizada (arenisca, caliza, piedra azul) y los fenómenos de degradación observados, con el fin de crear la base para definir relaciones entre carácter y patologías. Teniendo en cuenta los dictados de la Carta de Burra, que establece los criterios culturales y operativos a seguir en los trabajos de restauración, se han descrito algunas obras significativas, destacando los métodos operativos y los principales problemas de conservación.
Diagnóstico y análisis del Urnario de Bayardo en el Cementerio del Norte de Montevideo
Authors: Fontana Juan José , Romay Carola , Varin Claudia , Zubeldía Guillermo
Published: December 2022

El Urnario Municipal del Cementerio del Norte, ubicado en el municipio D de Montevideo, Uruguay, fue declarado Monumento Histórico Nacional en 2014. No cuenta hasta la fecha con un plan que habilite su conservación y mantenimiento a pesar de las claras señales de deterioro que presenta. Se plantea en este artículo un análisis de la configuración constructiva del edificio basado en levantamientos, resultados de ensayos y una modelización teórica de su estructura. Las lesiones detectadas se han clasificado según el grado de afectación del edificio. Finalmente, se establece un diagnóstico. El edificio  presenta síntomas de afectación, especialmente de sus elementos estructurales horizontales. En las condiciones actuales estas deficiencias no comprometen su estabilidad; sin embargo, dada la naturaleza progresiva de los procesos patológicos detectados, vinculados a la pérdida de alcalinidad y a la alta permeabilidad del hormigón, es previsible que pueda verse comprometido su desempeño a corto plazo.
A nyelvvizsga-moratórium margójára: Nyelvtanárok és idegen nyelven szaktárgyakat oktatók véleményei
Authors: Fajt Balázs , Bánhegyi Mátyás , Vékási Adél , Cseppentő Krisztina
Published: December 2022

2020 tavaszán a COVID-19 járványhelyzetben hozott rendkívüli kormányrendelet értelmében kb. 135 ezren kaphattak diplomát a legalább B2-es szintű nyelvtudást bizonyító nyelvvizsga-bizonyítvány megszerzése nélkül. A rendelet hatására a nyelvvizsga-moratóriumnak köszönhetően sokan szerezhettek végzettséget és léphettek be a munkaerőpiacra. Az intézkedés megítélésével kapcsolatos tudományos kutatások még nem láttak napvilágot: tanulmányunk ezt az űrt hivatott betölteni. Erre tekintettel a nyelvoktatói szakma és az idegen nyelven szakmát oktatók körében a nyelvvizsga-moratóriumról és a nyelvvizsga hiányában át (nem) vett diplomák kérdésköréről nagymintás, kvantitatív kérdőíves vizsgálatot végeztünk. Kérdőívünkkel többek között nyitott kérdések segítségével kvalitatív adatokat is igyekeztünk begyűjteni. Kérdőívünket összesen 769 különböző intézményekben dolgozó nyelvtanár, illetve idegen nyelven oktató szaktanár töltötte ki. Eredményeink alapján elmondhatjuk, hogy a kitöltők jelentős része – különös tekintettel a nyelvvizsgáztató nyelvtanárokra – szakmai szempontok mentén megkérdőjelezi a rendeletet, illetve annak gazdasági hatásait és társadalmi igazságosságát. Ugyanakkor nem rajzolódik ki olyan szakmai álláspont, amely az összes vélekedésnek keretet tudna adni és azokat át tudná fogni, így elmondhatjuk, hogy a szakma a nyelvvizsga-moratóriumot illetően megosztott.
Beyond walking: An assessment and description of streets as potential physical activity places in low-income communities
Authors: Umstattd Meyer M. Renée , Prochnow Tyler , Ylitalo Kelly R. , Gómez Luis , Sharkey Joseph R.
Published: December 2022

Low-income communities often have fewer quality community-level physical activity places (PAPs) or resources (e.g., parks, playgrounds). When present, barriers like traffic, distance, and crime often prevent access. Creative solutions and better understanding of current and potential realistic PAPs are necessary for children and families to be active. Streets are rarely considered potential PAPs despite their ubiquity and accessibility. This article describes street segments as potential PAPs in low-income Mexican-heritage colonias communities along the Texas-Mexico border. Promotora-researchers conducted modified PAP assessments to describe the availability and quality of physical activity features, amenities, and incivilities of all street segments (n=867) in two low-income colonias regions along the Texas-Mexico border. Streets in these communities did contain features and amenities associated with physical activity promotion. On average, street segments had 6.10 (SD=7.20) physical activity-promoting features, 26.60 (SD=27.30) physical activity-promoting amenities, and both were assessed as good-to-fair quality. Future physical activity programming should consider incorporating streets as potential PAPs to enhance physical activity and active play. Further, evaluating streets as PAPs in this way may provide insight into locations for temporary place-based programs such as Play Streets. Future research should also examine residents’ perceptions of their streets as PAPs for safe physical activity and active play, not just as places to walk, and which PAP characteristics matter for safe physical activity and active play to occur on streets.
Physical education teachers’ perceived effectiveness in association with student attendance, teacher adaptability, external educational supports, and teaching format during the COVID-19 pandemic
Authors: Kuhn Ann , Thompson Hannah , Webster Colin , Burgeson Charlene , Chriqui Jamie , Okutoyi Tevin , Hager Erin
Published: December 2022

Spring 2020 pandemic-control policies included an abrupt shift to remote teaching, which may have affected physical education (PE) teachers’ perceived effectiveness. This study examines PE teachers’ perceived effectiveness in association with student attendance, teacher adaptability, PE supports, teaching format (in-person, remote synchronous, remote asynchronous, etc.), and teacher- and school-level demographics at three time points (before the pandemic, Spring 2020, and the 2020-2021 school year). An electronic survey was developed by an expert panel and distributed to U.S. public school PE teachers (convenience sampling via school health-related organizations). For analyses, teacher perceived effectiveness was dichotomized (very/extremely effective= “1”; not at all/slightly/moderately effective= “0”). Logistic regression models assessed associations between perceived effectiveness and independent variables (student attendance, teacher adaptability, PE supports, teaching format, and demographic variables) at each time point. Respondents (n=134; M age=46) were mostly female (62%), general PE teachers (82%, versus adapted), had a graduate degree (66%), had 0-10 years of teaching experience (37%), and were from 26 states. Perception of being very/extremely effective was highest before the pandemic (93%), lowest in Spring 2020 (12%), and recovered somewhat in 2020-2021 (45%). During the 2020-2021 school year, teachers had greater odds of perceiving they were more effective if they reported having higher student attendance (OR 1.06 [CI:1.02-1.09], p>.001) and higher adaptability (OR 1.22 [CI: 1.09-1.37], p>.001), adjusting for gender, education level, years of experience, school type, and title I status. Professional development opportunities are needed for remote teaching of PE to enhance teachers’ adaptability and perceived effectiveness during potential future school closures.
Wrist radiography for hand bone age tells a lot; a girl with SHOX deficiency
Authors: Maraşlı Hüsnü , Çelik Nurullah , Sidar Duman Yeşim
Published: December 2022

Madelung's deformity (MD) occurs as a result of premature closure of the medial and volar aspects of the distal radial physis.1 It is more frequent and severe in girls, and usually develops in middle/late childhood.2 MD is one of the most characteristic features of he short-stature homeobox gene (SHOX) deficiency, which causes short stature3. Radial bowing is one of the  well-known radiological futures. On the other hand, there are three typical radiological sign of the hand radiograph for SHOX deficiency; triangularization, pyramidalization of the os lunatum, and radiolucency at the distal radius4.

     In the evaluation of a 9-year-old girl who was investigated for precocious puberty, her height measurement was 18th percentile. On the wrist X-ray taken for the determination of the bone age of the patient, there was an appearance compatible with MD (Figure 1). In the genetic studies of the patient with MD, normal female karyotyping (46, XX) was demonstrated by Trypsin G banding Technique. Heterozygous SHOX deletion was detected by Fluorescence In Situ Hybridization technique using a probe specific to the SHOX gene region (Xp22.33).

     Interpreting the direct X-ray is important in recognizing the MD. Thus, it will be easier to detect SHOX gene deletion in the etiology of short stature patients with this deformity.
Evaluation of Thiol/Disulfide Homeostasis and Neurogenin 3 Levels as a Marker of Oxidative Stress in Children and Adolescents Newly Diagnosed with Type 1 Diabetes
Authors: Deliktaş Gözde , Deveci Sevim Reyhan , Ünüvar Tolga
Published: December 2022

The objective of the study was to determine the relationship between autoimmunity and dynamic thiol/disulfide, neurogenin 3 (ngn 3) status in the newly diagnosed with type 1 diabetes mellitus (T1DM), the level of treatment, and thiol/disulfide homeostasis and neurogenin 3, and to found the changes in neurogenin 3 level due to beta cell damage in children newly diagnosed with T1DM. Totally 60 children aged 1-18 years old, 30 of them newly diagnosed with type 1 diabetes (patients), and 30 of them healthy children in the same age group (control) were included in the study. Insulin and C-peptide levels of newly diagnosed T1DM patients were lower than the control group, however, HbA1c, glucose, creatinine, cholesterol, triglyceride, and LDL levels were found higher in patients. Total thiol level and Gad antibody positive rate were found higher in children newly diagnosed with T1DM. In addition, it was observed that the rate of anti-insulin antibody positivity increased in the 6th-month control of patients. However, HbA1c and glucose levels at diagnosis were higher in patients compared to the control group at the sixth month. Insulin and C-peptide levels were determined lower in patients admitted with diabetic ketoacidosis. A negative correlation was observed between native thiol and anti-insulin antibody parameters and a positive correlation between ngn 3 and total cholesterol and LDL. In conclusion, thiol/disulfide homeostasis and ngn 3 parameters can be used as oxidative stress markers in children and adolescents newly diagnosed with T1DM.
AUDITORIA EM ÉPOCAS DE CRISE:
Authors: Cordeiro da Silva Paiva Nabila , Ribeiro Toso Camila , Nunes da Silva Raquel , De Souza Machado Lúcio , Rílany Rodrigues Machado Michele
Published: December 2022

Tendo em vista o impacto da SARS-CoV-2 na economia mundial, este trabalho objetiva compreender a influência da crise na qualidade da auditoria das empresas brasileiras listadas na B3. Para uma amostra de 268 empresas, foram obtidos os dados contábeis dos três primeiros trimestres de 2019 e 2020, necessários para se medir a qualidade da auditoria. Para a comparação dos resultados, empregaram se testes de média e regressão com dados em painel. Os resultados do teste de média indicam que a crise pandêmica SARS-CoV-2 impactou negativamente na qualidade da auditoria, e este resultado foi corroborado pela regressão com dados em painel. A partir do resultado encontrado, é possível inferir um prejuízo na qualidade das informações contábeis e, consequentemente, na qualidade da auditoria, especificamente durante a crise de SARS-CoV-2, não refutando a hipótese de pesquisa estabelecida. O achado sugere que os gestores podem estar propensos à manipulação de seus resultados, principalmente por se tratar de um momento mundial instável e a evidenciação de seus resultados pode ocasionar impacto no mercado financeiro. A pesquisa pode contribuir com a literatura, no papel de consolidar os efeitos de eventos adversos nos estudos relacionados à qualidade da auditoria que possibilitam um ganho quanto à qualidade informacional, e, portanto, que podem mitigar a assimetria informacional.
A INFLUÊNCIA DA MÍDIA SOCIAL NO VALOR DA PETROBRAS
Authors: Dias Almeida Milene , Mothé Maia Vinicius , Tommasetti Roberto
Published: December 2022

A presente pesquisa visa contribuir com a discussão sobre o sentimento do investidor. O objetivo do trabalho foi analisar a relação entre o sentimento exposto no Twitter e o retorno da Petrobras. Desse modo, tweets sobre a Petrobras, no período de 2010 até 2020, foram analisados a fim de se verificar se o sentimento textual dessas mensagens impacta no retorno. O método escolhido para classificar as palavras foi o mapeamento perceptual conjuntamente com a média e desvio padrão da frequência dos termos em dias positivos ou negativos. Os resultados apontaram que a variação do sentimento total e a variação do sentimento negativo tem relação com o retorno. A variação do sentimento é significativa quando o mercado está pessimista, demonstrando que a variação negativa do sentimento intensifica o movimento pessimista do mercado e ameniza a queda do mercado quando a variação do sentimento é positiva. Os achados corroboram com a teoria de finanças comportamentais de que o sentimento possui relacionamento com o retorno, no caso do estudo, o sentimento textual. Por fim, foram analisadas diferentes amostras com a mesma metodologia. Com isso, foi possível verificar que os indivíduos falam mais sobre a estatal, de modo geral, do que sobre os tickers da ação ou com a própria empresa na sua página oficial.
ANÁLISE EPISTEMOLÓGICA DO 3º CONGRESSO UFU DE CONTABILIDADE
Authors: Magrini Vagner de Oliveira , Santos Geovane Camilo , Silva Marli Auxiliadora , Soares Eduardo Codevilla
Published: December 2022

O objetivo deste estudo foi analisar empiricamente quais pressupostos epistemológicos nortearam os 78 artigos aprovados e publicados nos anais do 3º Congresso UFU de Contabilidade. Para a análise, foram considerados os paradigmas de Burrel e Morgan (1979) que compõem o Framework das pesquisas sociais. Metodologicamente trata-se de uma pesquisa com abordagem paradigmática interpretativa, com procedimentos de pesquisa documental. Os principais resultados revelaram que 82% das pesquisas se enquadram no paradigma funcionalista, que é caracterizado por ontologia realista e epistemologia positivista; enquanto apenas 18% dos artigos configuram se como interpretativistas, apresentando ontologia nominalista e epistemologia anti-positivista. Constatou-se, quanto ao conteúdo das pesquisas, que em nenhuma delas foi realizada análise dos aspectos ontológicos e epistemológicos, cujas reflexoes, apesar de não serem obrigatórias, se ausentes pode sugerir a falta de conhecimento sobre esses aspectos ou preocupação dos pesquisadores apenas com elementos metodológicos, ignorando os fatores ontológicos e epistemológicos que são fundamentais para a construção e o entendimento da pesquisa científica. Confirmou-se também que apenas 19 dos artigos aprovados e publicados fizeram uso explícito de alguma teoria para fundamentação do referencial teórico e discussões. Além disso, a maioria dos trabalhos, em um total de 50, fez uso da abordagem quantitativa. A conclusão é que neste evento específico, o 3º Congresso UFU de Contabilidade, o paradigma dominante em pesquisas contabeis persiste e evidencia a importância do desenvolvimento de pesquisas em paradigmas alternativos ao positivismo, mediante o incentivo pelo evento de estudos com outras abordagens paradigmáticas.
A Molecular Docking Approach to Evaluate the Pharmacological Properties of 1-(4-amino-1,2,5-oxadiazol-3-yl)-N'-(1-(3-hydroxyphenyl)vinyl)-5-(thiophen-2-yl)1H-1,2,3-triazole-4-carbohydrazide Treatment Candidate for Use against COVID-19
Authors: ALAMİN MOHAMMED AHMED Mohamed
Published: December 2022

In recent years, the new coronavirus known as COVID-19 has recently caused a pandemic that has caused serious health problems. Currently, the virus is spreading rapidly all over the world , and finding potential antiviral drugs that can inhibit virus proteins is crucial. Recently, CoVID-19 crystal structure elucidated such as major protease Mpro (PDB: 6LU7), SARS-CoV- main peptidase (2GTB), human ACE2 (PDB: 1O86), human coronavirus papain-like proteases (PDB: 4OW0) SARS-Coronavirus NSP12 protein (PDB: 6NUR), COVID-19 main protease (PDB:6lu7) . These proteins are important for replication of virus , so they are potential targets for CoVID-19 drugs.

In this study, we used the molecular docking models to study the binding interactions between anodyne called 1-(4-amino-1,2,5-oxadiazol-3-yl)-N'-(1-(3-hydroxyphenyl)vinyl)-5-(thiophen-2-yl)-1H-1,2,3-triazole-4-carbohydrazide(Zinc ID 000002613203) using MOE 2015.10.

It has been observed Obtained results by molecular docking showed that a stronger bond and high affinity with 4OW0 -8.1949, 6lu7 -7.7925, 1O86-7.5757, -6.7832 -7.4101, 2GTB -7.2510 kcal/mol)

Based on the binding energy score, these compound are suitable for testing against Coronavirus and could be considered potential inhibitors COVID-19 infection.)
Antiplamodial effect of sulfadoxine/pyrimethamine/clindamycin: A study in parasitized mice
Authors: ADIKWU Elias , IGONO AJEKA Simeon , NWORGU Confidence Orgechi
Published: December 2022

Triple antimalarial combination therapies may overcome the emergence of antimalarial drug resistance. Sulfadoxine/pyrimethamine (S/P) is an antimalarial drug. Clindamycin (C) has potential antiplasmodial effect. This study assessed whether the antiplasmodial activity of S/P can be augmented by C on Plasmodium berghei-infected mice. Adult Swiss albino mice (25-30g) were grouped and infected with Plasmodium berghei. The mice were orally treated daily with S/P (21.4/10.7 mg/kg), C (10mg/kg) and S/P/C, respectively using curative, prophylactic and suppressive tests. The normal and negative controls were treated daily with normal saline (0.2mL) while the positive control was orally treated with chloroquine (CQ) (10mg/kg). After treatment, blood samples were collected and evaluated for percentage parasitamia and hematological parameters. Mice were observed for mean survival time. In the curative, suppressive and prophylactic tests, S/P/C significantly decreased parasitamia levels when compared to SP or C at p< 0.05. S/P/C significantly prolonged mean survival time when compared to S/P or C with difference at p< 0.05. S/P, C, and S/P/C produced 65.62 %, 62. 03 % and 85.31 % parasitamia inhibitions, respectively while CQ produced 83.72 % parasitamia inhibition. S/P/C caused significant reduction in anemia marked by increased packed cell volume, hemoglobin, red blood cells and decreased white blood cells at p< 0.05 when compared to SP or C. S/P/C eradicates liver merozoites and central vein congestion. C increased the antiplasmodial activity of S/P, therefore S/PC may be used for malaria treatment.
Detection of The Effect of CYP2C19*4 Mutation on Clopidogrel Response by In Silico Methods
Authors: KÖPRÜLÜLÜ KÜÇÜK Gizem
Published: December 2022

Single nucleotide polymorphisms cause amino acid change, and protein structure and function are changed. Thus, the patient improves drug resistance and does not respond to therapy. Clopidogrel is an antiplatelet drug and is used for cardiovascular disease therapy such as heart failure, atherosclerosis, and myocardial infarction.CYP2C19 gene is a CYP450 enzyme and metabolizes clopidogrel. Polymorphism of the CYP2C19 gene causes clopidogrel response. A homology modeling study was carried out using the Swiss-Model database and the Chimera program. The selection of models was made with the evaluation of the QMEAN values of the three-dimensional structures. The physicochemical properties of the wild type and CYP2C19*4 mutant type were analyzed by the ExPASy-ProtParam Portal. The effects of the mutation on the protein structure were performed by the HOPE database. The HDock program was used to demonstrate interactions between clopidogrel and wild-type protein and, mutant type protein. Mutation of the residue might disturb this function. This mutation causes the loss of interactions and affects the drug response. In this study, it was shown that Clopidogrel drug interactions between mutant type protein by docking study. Possible drug conformation is designed for the effective treatment of patients carrying the common mutation.
Pitolisant Hydrochloride (Wakix)
Authors: CADTH
Published: December 2022

CADTH recommends that Wakix not be reimbursed by public drug plans for the treatment of excessive daytime sleepiness (EDS) or cataplexy in adult patients with narcolepsy.

It is still not known whether Wakix offers any therapeutic benefit over other treatments used for EDS or cataplexy. Two double-blind, randomized, controlled, comparative studies failed to show that Wakix was at least as good as modafinil for treating EDS and did not show any clinical benefit of Wakix over modafinil. One study focused on cataplexy, but this study was versus placebo and results were inconsistent for cataplexy outcomes across the studies.

Based on the evidence, the expert committee could not conclude that Wakix met any of the needs that were identified as important to patients, including being more effective and reliable for controlling narcolepsy symptoms and to which patients would be less likely to develop tolerance.
PENGARUH MOTIVASI KERJA DAN BUDAYA ORGANISASI TERHADAP KINERJA KARYAWAN CV. BONANZA
Authors: Pindo Asti  , Didik Sofian Haryadi  , Afif Nala Niam
Published: December 2022

The progress of an organization can be seen from the performance of its employees which can be triggered by work motivation and a good organizational culture. The research conducted by the author tries to understand and analyze how much influence work motivation and organizational culture have in improving employee performance. The research was conducted at CV. Bonanza in Boyolali district with multiple linear regression analysis method with the help of SPSS 23.0 software. The sampling technique used was saturated sampling, where the entire population was sampled as many as 30 respondents. The results show that the variables of work motivation and organizational culture have a positive and significant influence on employee performance. The work motivation variable has a very dominant influence as evidenced by the largest t-value with a value of 4.330.
ANALISIS PENGARUH KUALITAS PELAYANAN, HARGA DAN PROMOSI TERHADAP KEPUTUSAN PEMBELIAN GRABFOOD DI KOTA BOYOLALI
Authors: Zahro Maftuhah Hasanah  , Titin Hargyatni
Published: December 2022

The results of multiple linear regression analysis obtained the equation Y = -1.824 + 0.595X1 + 0.471X2 + 0.268X3. The t-test analysis of the results for t-count service quality is 8,194 > ttable 1,986, so there is a positive and significant influence on the purchasing decision of Grabfood Online in Boyolali City. Analysis of the t-test results for t-count prices of 8.313 > ttable 1.986, then there is a positive and significant effect of the variable on the purchasing decision of Grabfood in Boyolali City. The t-test analysis obtained for t-count Promotion is 4,394 > ttable 1,986, so there is a positive and significant effect of promotion variables on Grabfood purchasing decisions in Boyolali City. Based on the analysis of the F test, the results obtained for the magnitude of the calculated F of 108,491 > F table 2,311, then together there is a significant influence between independent. Variables of Service Quality, Promotional Prices, To Purchase Decisions for Grabfood in Boyolali City. There is an influence between variables, namely Service Quality, Price, Promotion, Grabfood purchasing decisions in Boyolali City by 76.5%, while 23.5% is influenced by other factors that are not examined on customer satisfaction, customer loyalty, image or brand.
PENGARUH GROWTH OPPORTUNITY DAN LIKUIDITAS TERHADAP NILAI PERUSAHAAN DENGAN STRUKTUR MODAL SEBAGAI VARIABEL INTERVENING
Authors: Hasmaynelis Fitri  , Zigo Triansyah  , Bayu Putra Ramdani , Bayu Pratama Azka
Published: December 2022

This study aims to determine how the effect of Growth Opportunity, Liquidity on Firm Value with Capital Structure as an intervening variable. The population in this study are companies in the manufacturing sector listed on the Indonesia Stock Exchange for the period 2016-2020. While the sample in this study was obtained using purposive sampling method so that 30 companies were obtained as samples. The type of data used is secondary data taken through www.idx.co.id. The data analysis method used is panel data regression analysis. Based on the results of the study, it was concluded that partially, Growth Opportunity had a negative and significant effect on Capital Structure. Partially Liquidity has a negative and significant effect on the Capital Structure. Partially, Growth Opportunity has no effect on Firm Value. Partially, liquidity has a positive and significant effect on firm value. Partially, the capital structure has no effect on firm value. Capital structure cannot mediate the effect of Growth Opportunity on Firm Value. Capital structure can mediate the effect of liquidity on firm value
Injecting Health Information? The Channeled Role of Radio Personalities in the Vaccination Status of Older Adults
Authors: Villarin Larry V.
Published: December 2022

On top of the country’s predicament to bolster the number of vaccinated older adults is the perpetuating transmission of health mis- and disinformation. Following the approach of Grounded Theory, this study examined the role of radio personalities in the vaccination status of older adults drawing from the data of the 14 semi-structured interviews: seven vaccinated and seven unvaccinated. The study found that radio personalities contribute to their attitudes and behavior about the COVID-19 vaccines. The recurring information learned by older adults from them led to the discovery of wired and unwired trusts, placing both agents in the line of responsibility. This interpretation was derived from the dominant themes emanated by the channel of motivation, views toward radio personalities, emerging mis- and disinformation, credibility indicators, and substantiating information. The study recommended a full-swing collaboration between radio entities and health agencies to increase vaccination uptake among older adults.
Social Construction of Vulnerability amidst Crisis Situations and Neoliberal Reforms: The Case of Smallholder Rice Farmers in Lumban, Laguna, Philippines
Authors: Habacon John Patrick P.
Published: December 2022

This article examines how Filipino rice farmers experience vulnerability in the face of persistent and emergent crises coupled with the challenges induced by the neoliberal transformation of the country's agricultural sector. Using the case study approach, eight smallholder rice farmers from Lumban, Laguna, were purposely interviewed, and their narratives were thematically analyzed. Recurrent themes revealed that although the participants viewed risks induced by crises as "normal" aspects of rice farming systems, they primarily attributed the intensification of their vulnerability toward risks to the enduring systemic issues that have been affecting the dynamics of their rice farming operations even prior to, and during the occurrences of crisis events. Furthermore, the smallholder rice farmers were found to be resource-limited and socially disadvantaged due to long-standing concerns associated with the neoliberal policies imposed by the government. This article argues that increased public sector involvement is imperative rather than shifting support away from the farmers.
Assessment of Psychological Problems and Its Associated Factors Among Post CABG Patients Attending OPD in a Selected Hospital of Kolkata, West Bengal
Authors: Saha Sreyasree
Published: December 2022

Patients undergoing coronary artery bypass grafting surgery often face psychological problems even after getting discharge from the hospital which has a strong influence in recovery during post-operative period. So, a study to assess the psychological problems among the post CABG patients attending OPD was conducted with the aim to assess the psychological problems and its associated factors. A quantitative descriptive survey research approach was adopted to collect data from 100 patients selected by non-probability sampling technique. Standardised DASS 21 scale and Pittsburgh Sleep Quality Index scale were administered by interview method to collect data related to psychological problems and a semi-structured interview schedule to assess the factors associated with psychological problems. Findings revealed that majority (57%) of the patients had no depressive features, maximum(33%) number of patients had mild anxiety, majority(85%) of the patients had normal stress levels and majority(61%) of the patients suffer from bad quality of sleep. The main factors associated with the psychological problems were loss of independence, feeling disturbed about present body image and feeling disturbed due to physical discomfort. The computed chi square (χ2) result showed that there is no significant association between psychological problems and selected demographic variables. Present study had several implications in nursing research, administration, nursing practice and nursing education. The present study recommended to conduct further studies regarding different measures adopted by post CABG patients to overcome psychological problems.

Key words: post CABG patients, psychological problems, OPD
Description of Anxiety Level of Medical Faculty about Online Learning Systems
Authors: N. Achmad Luana , Monike Naami Belencia , Marie Lengkong Joyce Vera
Published: December 2022

The emergence of the Covid-19 pandemic, namely a respiratory tract disease caused by the SARS-CoV-2 virus (Severe Acute Respiratory Syndrome Corona Virus 2) in Indonesia, resulted in many changes, one of which was a change in the education sector by holding online learning activities. This online learning activity can cause anxiety in students. The purpose of this study was to describe the level of anxiety of Indonesian Christian University medical faculty students class of 2018 about the online learning system. The method used is descriptive quantitative with the cross-sectional approach. Data was collected using the HARS questionnaire (The Hamilton Anxiety Rating Scale). This study found that 38.3% of Medical Faculty students in a class in 2018 experienced anxiety with various levels of anxiety, namely mild anxiety at 17.5%, moderate anxiety at 9.1%, severe anxiety at 8.4%, and severe anxiety once by 3.2%. This anxiety is influenced by several factors, namely gender, age, and environmental conditions of the student.

Key words: anxiety level, online learning, student anxiety
Effect of Extracorporeal Shock Wave Therapy on Pain and Function in Patient with Tennis Elbow: An Evidence Based Study
Authors: Chauhan Mukul , Patel Ankita , Dabhi Asha
Published: December 2022

OBJECTIVE: The aim of the study is to review the available literature on the use of Extracorporeal Shock Wave Therapy (ESWT) for the treatment of Tennis elbow to understand its therapeutic potential.
MATERIALS AND METHODS: A systematic review was performed on the PubMed, Scopus, Science Direct, and Research Gate databases with the following inclusion criteria: Studies published in last 08 years. (2015 to 2022) Studies that includes subjects with Tennis Elbow.
RESULTS: 20 studies were reviewed from which 10 studies concluded that ESWT is effective in Tennis Elbow patients.
CONCLUSIONS: Based on the analysis of these 10 articles, it can be concluded that ESWT is an effective treatment regimen in individual with Tennis Elbow patients.

Key words: Extracorporeal Shock Wave Therapy (ESWT), Tennis Elbow, Pain, Grip Strength.
Orta Çağ Doğu Karadeniz Türk Tarihinin Kaynakları Üzerine Bir Değerlendirme
Authors: SARIYILDIZ Bekir
Published: December 2022

Tarihi kaynaklar ışığında Doğu Karadeniz’deki Türk varlığının tarihi temellerini çok derinlere götürmek mümkündür. Orta Çağ’da ise Doğu Karadeniz’deki Türk varlığı hakkındaki bilgiler Selçukluların Anadolu’ya temasıyla önem kazanmaktadır. Selçukluların Kafkaslara ve Doğu Anadolu’ya gelmesiyle birlikte bölgedeki Gürcü ve Ermeni kaynakları Selçuklulardan bahsetmeye başlamaktadır. Aynı şekilde Anadolu’yu yöneten Bizanslılar ile bölgeyle yakından ilgilenen Araplar ve Süryanilerde bölgede gerçekleşen Türk faaliyetleri hakkında mühim kayıtlar tutmuşlardır. Orta Çağ tarihi kaynakları incelendiğinde, Selçukluların Doğu Karadeniz’in Çoruh boylarında ve Kelkit havalisinde faaliyetleri hakkında önemli kayıtlar bulunmaktadır. Ancak Doğu Karadeniz kıyılarına ulaşan Türkler hakkında bilgiler başlangıçta karanlıkta kalmaktadır. İlerleyen dönemde ise Doğu Karadeniz vadi ve sahillerindeki Türkler hakkında tarihi kaynakların yardımıyla önemli bilgiler edinilebilmektedir. Kaynaklardaki kayıtlar çoğunlukla Kelkit Havzası’ndaki Türk siyasi teşekkülleri ve Doğu Karadeniz dağlarının kuzeyini kendilerine yurt edinen Türk beylerinin, Trabzon Rum Devleti ile olan mücadelelerini konu almaktadır.
1929 EKONOMİK KRİZİNİN TÜRK BASININDAKİ YANSIMASI
Authors: YAMAN Rabia , KOPAR Metin
Published: December 2022

Toplumların, ihtiyaçlarını karşılayabilmek adına giriştikleri faaliyetleri kapsayan ekonomi, aynı zamanda refahla da doğru orantılıdır. Bu iktisadi refahı sağlamak kadar dengede tutmak, sürekliliğini korumak da oldukça önemlidir. Ekonomiyi dengede tutabilmek için ise tam anlamıyla oturmuş bir iktisadi sisteme ve savaştan uzak bir ortama ihtiyaç vardır. Zira tarihteki emsallerinden de görülebileceği gibi savaş, yalnızca savaş taraftarı devletlerin değil, tüm dünya devletlerinin ekonomilerini sarsan bir durumdur. Fakat 1900’lü yılların ilk çeyreği incelendiğinde savaştan uzak bir dünyayla karşılaşmak pek de mümkün değildir. Bu dönemde dünya, birçok savaşla karşı karşıya kaldığı gibi, özellikle I. Dünya Savaşı’yla zorlu bir sürece girmiştir. Ekonomiyi derinden etkileyen bu savaşı en az hasarla atlatan devlet ise ABD olmuştur. Fakat özellikle Avrupa’ya verdiği kredilerin ödenememesi ve beklentilerinin karşılanmaması ABD’yi, büyük krize doğru sürüklemiştir.
ABD’de 1929 yılında, borsadaki ani düşüşle patlak veren fakat bunun dışında da birçok sebebi olan kriz, kısa sürede Avrupa’yı etkisi altına almıştır. Dönemin en güçlü ekonomisinin bir anda çökmesiyle başlayan bu krizin Türkiye’de kendine yer bulması da zor olmamıştır. Fakat krizden etkilenen diğer devletlere nazaran bu süreci daha az hasarla atlatan Türkiye’de krizin ayak sesleri, Türk lirasının değer kaybetmesiyle başlamış ve ithalat ve ihracatın düşmesiyle de devam etmiştir. Genç Türkiye’nin karşısına çıkan bu ilk kriz, Türk basınında da uzunca bir süre yer edinmiştir. İlk etapta yalnızca Türk lirasının değer kaybından bahseden gazeteler bir süre sonra krizin Türkiye’yi de etkilediğini vurgulamaya başlamışlardır. Bu çalışmada da 1929-1930 yılları arasında Türkiye’de yayımlanan bazı gazeteler incelenmiş ve ekonomik krizin basındaki yansımalarına yer verilmiştir.