bluuebunny/crossref_metadata_2025 huggingface dataset:
Boroxazolidones: Synthesis, In Silico and In Vitro Evaluation as ACE/AChE Dual Inhibitors, and In Vivo Testing of Antihypertensive Activity
Authors: Alina Barquet-Nieto , José G. Trujillo-Ferrara , Erik Andrade-Jorge , Jessica E. Rodríguez- Rodríguez , Itzell A. Gallardo-Ortíz , Rafael Villalobos-Molina
Published: September 2024

Background:

Systemic arterial hypertension is a serious chronic health
problem caused by multiple factors. It is a major risk factor for Cardiovascular Diseases
(CVDs), including heart failure, coronary heart disease, and myocardial infarction. Hypertension
can be effectively treated with inhibitors of the Angiotensin Converting Enzyme
(ACE), such as captopril, enalapril, and lisinopril. However, these drugs are associated
with significant adverse reactions (e.g., persistent coughing, skin rashes, and angioedema).

Objective:

Considering the recent insights obtained by our group into the antihypertensive
effect of boroxazolidones, the aim of the current contribution was to design and synthesize
a series of these compounds derived from α-amino acids and evaluate them (in
silico and in vitro) as inhibitors of ACE and acetylcholinesterase (AChE).

Methods:

The best candidates were examined for their in vivo antihypertensive activity
to regulate high blood pressure in male spontaneously hypertensive rats. Although
boron-containing compounds were once thought to be toxic in any medical context, they
have increasingly been used as antibiotics, antiseptics, and antineoplastic agents. BXZHis,
BXZ-Lys, BXZ-Orn, BXZ-Phe, and BXZ-Pro were selected in silico as promising
ACE and AChE inhibitors. After synthesis, these molecules were tested in vitro as ACE
and AChE inhibitors, finding that most were effective at micromolar concentrations.
The two best candidates, BXZ-Lys and BXZ-His, were evaluated in vivo with spontaneously
hypertensive rats.

Results:

BXZ-Lys significantly decreased systolic, diastolic, and mean blood pressure,
being more potent than a common ACE inhibitor, captopril.

Conclusion:

Future research is required to elucidate the mechanism of action of this antihypertensive
effect.
An Overview of the Analytical Methods for Products Based on Clindamycin and Eco-efficiency Perspectives
Authors: Lustosa Isadora Alves , Kogawa Ana Carolina
Published: September 2024

Background:

Clindamycin (CLIN), an antibiotic sold in the form of capsules, injectable solution,
gel, and lotion, is easily soluble in water and ethanol. However, it lacks eco-efficient methods for evaluating
pharmaceutical products.

Objective and Method:

The objective of this review is to provide an overview of the analytical methods present
both in the literature and in official compendia for evaluating pharmaceutical matrices based on CLIN in
the context of Green Analytical Chemistry (GAC).

Results:

Firstly, microbiological methods for evaluating the potency of CLIN final products were not found,
which already shows the need to develop new methods. Among the methods found, which are all physicalchemical,
the most used method is HPLC (71%) followed by UV-Vis (14%). Among the targets of the methods,
capsules and raw materials were the most studied (33% each). Among the choices of analytical conditions
for the methods, acetonitrile is the preferred solvent (27.7%), even though CLIN is easily soluble in ethanol.

Conclusion:

Thus, the gap in eco-friendly and sustainable analytical methods is a reality and an opportunity
for analytical development centers to provide means for evaluating the quality of CLIN-based products.
Comprehensive Analysis of Tertiary Lymphoid Structures in Pancreatic Cancer: Molecular Characteristics and Prognostic Implications
Authors: Fang Jiana , Huang Jingru , Zhang Jiazhong , Chen Lin , Deng Jin
Published: September 2024

Purpose:

The molecular properties of TLSs in pancreatic cancer are still not well comprehended.
This research delved into the molecular properties of intratumoral TLSs in pancreatic
cancer through the exploration of multi-omics data.

Methods:

Seven key genes were identified through Cox regression analysis and random survival
forest analysis from a total of 5908 genes related to TLSs. These genes were utilized to construct a
prognosis model, which was subsequently validated in two independent cohorts. Additionally, the
study investigated the molecular features of different populations of TLSs from multiple perspectives.
The model’ s forecasting accuracy was verified by analyzing nomogram and decision curves,
taking into account the patients’ clinical traits.

Results:

The analysis of immune cell infiltration showed a notably greater presence of Macrophage
M0 cells in the group at high risk than in the low-risk group. The pathway enrichment analysis
demonstrated the activation among common cancer-related pathways, including ECM receptor interaction,
pathways in cancer, and focal adhesion, in the high-risk group. Additionally, the methylation
study revealed notable disparities in DNA methylation between two TLS groups across four
regions: TSS200, 5’ UTR, 1stExon, and Body. A variety of notably distinct sites were linked with
PVT1. Furthermore, by constructing a competing endogenous RNA network, several mRNAs and
lncRNAs were identified that compete for the binding of hsa-mir-221.

Conclusion:

Overall, this research sheds light on the molecular properties of TLSs across various
pancreatic cancer stages and suggests possible focal points for the treatment of pancreatic cancer.
Structural Optimization of Quinazolin-4-one Derivatives as Novel SARS-CoV-2 Mpro Inhibitors by Molecular Simulation
Authors: Wu Jinping , Li Peng , Mu Yucheng , Peng Ruiguang , Zhao Zhongyao , Lei Jinke , Tu Aiping , Gao Zhiting , Bai Yixiao , Wu Gang
Published: September 2024

Background:

Severe acute respiratory syndrome coronavirus 2 main protease (SARSCoV-
2 Mpro) has been shown to be an effective target for inhibiting novel coronaviruses, which can
be used as a crucial breakthrough for developing drugs to treat the coronavirus disease 2019
(COVID-19).

Methods:

To design novel SARS-CoV-2 Mpro inhibitors, we conducted 3D-QSAR, molecular docking,
and molecular dynamics (MD) simulation on 64 quinazolin-4-one derivatives.

Results:

Comparative molecular field analysis (CoMFA) model (q2 = 0.590, R2 = 0.962), comparative
molecular similarity index analysis (CoMSIA) model (q2 = 0.628, R2 = 0.923), and external validation
indicated that the stability, reliability, and prediction performance of our constructed model were excellent.
We designed 8 inhibitors with stronger antiviral activities through the three-dimensional equipotential
field. Molecular docking and MD simulation probed the interactions of compounds and SARS-CoV-
2 Mpro. This indicated that amino acid residues, including Met165, Met49, and Cys145, were very important
in combination with the compounds. The prediction results of ADME/T and Lipinski’s rule of
five indicated that the new compounds had favorable drug-like and pharmacokinetic properties

Conclusion:

This study provided new ideas for exploring novel SARS-CoV-2 Mpro inhibitors against
COVID-19 in the future.
Repurposing Drugs as Host-Directed Therapy in Tuberculosis
Authors: Xavier V Andrew Marie , Ravichandran Mirunalini
Published: September 2024

Tuberculosis is a chronic infective respiratory disease that has been known to mankind
for centuries and is still responsible for higher rates of morbidity and mortality globally. Repurposing
drugs as host-directed therapies as an add-on drug to tuberculosis is a promising scope to
study as it may have a significant impact in reducing the treatment duration and complications of
tuberculosis. Host-directed therapy is a strategy to target the host and its immune mediators responsible
for pro and anti-inflammatory pathways, thus modifying them with drugs to achieve increased
bacterial clearance and reduced long-term inflammatory-mediated complications of tuberculosis.
Various drugs approved for other indications have been studied in preclinical animal and
in vitro studies, as well as clinical trials in tuberculosis. These drugs mainly aim to improve mycobacterial
clearance and minimize post-TB consequences by suppressing inflammatory mediators.
Drugs such as metformin, imatinib, vitamin D, and (Vascular Endothelial Growth Factors)
VEGF drugs are studied for their ability to modulate the anti-inflammatory effects, and drugs,
such as doxycycline, corticosteroids, and N-acetylcysteine are being studied for their role as proinflammatory
modulators. This repurposing drug helps in using these drugs as an adjuvant in tuberculosis,
for which the safety is already established through various clinical trials post-marketing
surveillance. However, the interaction of these drugs with the standard anti-tubercular drugs
and with the disease needs to be studied. In the near future, this host-directed therapy might unlock
various management approaches not only in tuberculosis but also in other infective diseases
as the action of drugs is on the host.
Characterization and Antimicrobial Activity of Postbiotic from Lactobacillus Acidophilus LA5 on Staphylococcus Aureus in Food Model and In vitro
Authors: Khani Nader , Abedi Soleimani Roya , Homayouni Rad Aziz
Published: September 2024

Background:

Postbiotics, also called biogenics, metabiotics, or Cell-Free Supernatants
(CFS), are soluble compounds produced by live probiotic microorganisms or released after the lysis
of probiotics that could provide beneficial health effects to the host.

Objective:

This study was conducted with the aim of investigating the antimicrobial, antibiofilm,
antioxidant, and cytotoxic effects of postbiotics derived from Lactobacillus acidophilus.

Methods:

In this study, the antimicrobial properties of the postbiotic of L. acidophilus on Staphylococcus
aureus were investigated in different experimental settings, in-vitro, and pasteurized milk.
The antioxidant effect of postbiotic was also evaluated by 2, 2-diphenyl-1-picrylhydrazyl (DPPH)
and 2, 20-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) method. Furthermore, the
chemical composition of the postbiotics was identified via gas chromatography-mass spectrometry.
The cytotoxic effects of the compounds were investigated using a human normal cell line.

Results and Discussion:

According to the results, postbiotics had aconcentration-dependent antimicrobial
effect, and the inhibitory effect increased with increasing concentrations. The antimicrobial
activity was mainly linked with lactic acid and laurostearic acid. The Minimum Inhibitory
Concentration (MIC) of the prepared postbiotic was determined to be 100 mg/ml. The lowest Minimum
Effective Concentration (MEC) of postbiotics significantly differed in the food matrix, and a
low MEC (minimum effective concentration) index (150 mg/ml) was detected for postbiotic of L.
acidophilus.

Conclusion:

Therefore, the prepared postbiotic should be subjected to more in-depth analysis to
examine its suitability as a food additive.
Recent Advances of the Ultimate Microbial Influenced Corrosion (MIC): A Review
Authors: Albarqouni Yasin , Sanad Gomaa , Chong Kwok Feng , Abu Bakar Nurul Huda , Althubaiti Randa , Abdullah Arman
Published: September 2024

The persistent corrosion of metal surfaces poses a significant engineering challenge,
including material degradation, loss of metal-structural integrity, and massive maintenance costs
in various industrial, medical, and aerospace applications. Microorganisms such as archaea,
bacteria, fungi, and microalgae can directly or indirectly influence metal corrosion. The degree
of corrosiveness and corrosion healing varies depending on the microbe, medium, and metal
substrate characteristics. Several attempts have been made to reveal answers to all questions
about MIC. The published reports focused on testimonial failures and laboratory or field tests
under varied situations. This review offers an overview of the most recent MIC research and
emphasizes the scarcity of data on MIC detection, estimation, and the most recent approaches
for MIC management. The review extends previously reported works and summarizes efforts for
better understanding and cutting off MIC management in advanced technologies. Furthermore, it
concludes with a final discussion of the current and future drawbacks and protective systems for
preventing microbial-induced corrosion.
Preparation and Optimization of Beta-Sitosterol Nanosuspension-Loaded In situ Gel by Using Box-Behnken Model for the Treatment of Prostate Cancer
Authors: Patil Vaibhav L. , Rane Bhushan R. , Mane Nikita P. , Jain Ashish S.
Published: September 2024

Introduction:

Prostate cancer is the second most often occurring cancer in males and the
fourth most common cancer overall. Beta-sitosterol (β-Sit), the most prevalent plant phytosterol
found in several plant species, has been reported to have inhibitory effects against several malignancies.
Even though β-Sit has considerable potential, its therapeutic uses are limited due to its
poor aqueous solubility (<0.1 mg/ml), low bioavailability (0.41%), and poor absorption from GIT.
Nanosuspension is one of the most innovative approaches to address problems linked to low solubility
and poor absorption.

Methods:

In the present research work, β-Sit nanosuspension has been fabricated by nanoprecipitation-
ultrasonication, followed by high-pressure homogenization (Panda plus 2000) employing
HPMC E5 and poloxamer (188 and 407) as stabilizers, optimized using a Box-Behnken technique.
Subsequently, in situ nano gel was prepared by dispersion method using gellan gum as an ionsensitive
polymer by incorporating optimized nanosuspension.

Results:

The optimized nanosuspension was evaluated for various parameters and has been found
to have an average particle size (137 ± 5.07 nm), zeta potential (-24 ± 4.99), PDI (0.207), and improved
solubility up to 5 folds, being suitable for systemic absorption through the nasal route. The
optimized in situ gel was characterized and showed the desired viscosity, good spreadability, acceptable
gelation property, and sufficient mucoadhesive strength to adhere to nasal mucosa after
ionic interaction. The in vitro release of pure drug, nanosuspension, and the optimized gel was
compared, and optimized in situ gel showed a maximum release of 91.41 ± 1.32% up to 8 hours.

Conclusion:

It was concluded that the in situ nasal nanogel could be the best possible approach to
delivering β-Sit into systemic circulation for the treatment of prostate cancer.
Nanocurcumin-containing Spongy Membrane for Improving the Quality of Hard and Soft Tissues in the Extracted Tooth Area: A Double-Blind Split- Mouth Clinical Trial Study
Authors: Hessari Sina , Ahmadpour Farzin , Yazdani Javad , Golparvar Atashi Yasmin , Maleki Dizaj Solmaz , Sharifi Simin
Published: September 2024

Background: The assessment of the hard and soft tissue conditions is part of the overall
dental treatments.

Aim: In this study, we investigated nano curcumin-containing membranes to improve the quality
of the hard and soft tissues in the extracted tooth area as a clinical trial study.

Methods: After the patient was selected following the inclusion and exclusion criteria, the patients
who had teeth extracted from both sides of the mouth (split mouth) on the side of the intervention
received a membrane containing nanocurcumin, and on the control side, no material was placed in
the socket. For data analysis, SPSS software version 24 was used. A significance threshold was
deemed to be less than 0.05 in terms of probability.

Results: Two months after tooth extraction, during implant placement, the average gingival thickness
on the “intervention side,” was 3.1±0.34 mm, while the average gingival thickness on the
“control side” was 2.6±0.42 mm. Then, the membrane could improve the quality of soft tissue (P<
0.0001). As another outcome, the application of this membrane did not significantly affect bone repair
in these patients compared to the control group (P = 0.72). However, the histology data revealed
that the newly generated bone of the intervention group was seen close to the membrane,
demonstrating the osteoconductive ability of the membrane.

Conclusion: Based on the obtained results, the newly developed membrane can be used to improve
the quality of hard and soft tissues in the extracted tooth area. Nonetheless, more efforts in
nanocurcumin dosage adjustment are needed for hard tissue regeneration in future studies.
Research on Auxiliary Effect of Lorentz Force for On-orbit Servicing of Spacecraft
Authors: Zhang Liang
Published: September 2024

Background:

On-orbit servicing of spacecraft is mainly aimed at repairing failed spacecraft,
maintaining and upgrading normally operating spacecraft to extend their life in order to reduce
the increase of space debris and maintain the space environment.

Objective:

In performing on-orbit servicing, the spacecraft typically requires continuous control
force to hover for a long period of time in order to maintain a relatively stationary state towards the
target.

Methods:

Considering the limited amount of fuel carried, the Lorentz force is introduced into onorbit
servicing to assist spacecraft in hovering. In order to demonstrate the feasibility of using Lorentz
force as spacecraft thrust, many related patents have been provided.

Results:

Firstly, the velocity of the spacecraft's orbital motion and the variation of the geomagnetic
field were given, and the specific expression of the Lorentz force in the relative dynamics model of
the spacecraft was deduced. When studying the auxiliary effect of Lorentz force, a critical angle
was defined. The relation between the critical angle and the Lorentz force on the auxiliary effect of
spacecraft hovering was analyzed through numerical examples.

Conclusion:

Furthermore, based on the influence of the charge-to-mass ratio on the critical angle,
the variation law of the Lorentz force-assisted spacecraft hovering area with different charge-tomass
ratios was derived.
Automated External Bone Fixation Robot Design and Orthopedic Analysis
Authors: Shi Zhi , Su Peng , Zhao Wei , Xie Shihui , Liu Lin , Zhang Li
Published: September 2024

Background:

Bone external fixation technology is an important therapeutic approach for
limb correction, primarily involving a class of external fixation correction mechanisms. It has
achieved good results in limb lengthening and correcting deformities to restore limb function. In
clinical practice, existing correction mechanisms face challenges such as high resistance between
components, complex installation procedures, and high precision requirements for installation, requiring
manual adjustment by physicians, which limits precise control and quantification of correction
parameters.

Objective:

To address these issues, an automated correction bone external fixation robot was designed
based on traditional Ilizarov external fixation devices(TIEFD).

Methods:

By increasing the number of unidirectional hinge connections, the robot can effectively
reduce motion resistance. Subsequently, the robot was combined with the tibia for correction motion
simulation, obtaining the motion parameters θ of the deformed bones during the correction
process based on the trajectory of the tibia's point mass. Finally, correction motion experiments and
finite element analysis(FEA) were conducted on the robot combined with a control system.

Results:

The results showed that the robot could precisely control correction parameters, with the
error range for rotational correction not exceeding 0.5 radians and the error range for traction correction
not exceeding 0.2 mm. FAE, based on corrective force data, concluded that compared to
(TIEFD), the robot could reduce bone stress by 16 MPa during the correction process.

Conclusion:

The robot effectively reduces patient discomfort, this provides a reliable theoretical
basis for bone external fixation technology and holds positive significance for the treatment of skeletal
deformities.
Rapid Identification of Lactobacillus acidophilus and Bifidobacterium by a 16S rRNA PCR Method
Authors: Hazra Amit , Saha Pijush K , Bhattacharjee Dipanwita , Bhattacharyya Barun K.
Published: September 2024

Background:

Probiotics are live microorganisms that, when administered, have beneficial
effects on human health. Hence, various probiotic organisms belonging to the genera Lactobacillus
and Bifidobacterium are being increasingly used in food and pharmaceutical products. For
regulatory compliance, simple and reliable analytical methods are required for selective enumeration
of different probiotic organisms present in food and pharmaceutical formulations.

Objective:

This study aimed to establish a rapid PCR-based method for the identification and differentiation
of Lactobacillus acidophilus and Bifidobacterium strains.

Methods:

Species-specific and genus-specific primers for Lactobacillus and Bifidobacterium were
designed based on their 16S rRNA gene sequence. Genomic DNA of different Lactobacillus and
Bifidobacterium strains were subjected to PCR with annealing temperature specific for respective
primer pairs.

Results:

Lactobacillus acidophilus primers gave positive PCR results only with Lactobacillus acidophilus
strains and not with other Lactobacillus species, whereas Bifidobacterium genus-specific
primers gave positive PCR results with most of the Bifidobacterium strains.

Conclusion:

The three species-specific L. acidophilus primer pairs and three genus-specific primer
pairs of Bifidobacterium used in this study could easily identify and differentiate Lactobacillus acidophilus
and Bifidobacterium with high specificity.
Unveiling the Health Promising Benefits of Processed Foods Derived from Underutilized Edible Plants: A Review
Authors: Shams Rafeeya , Kumar Pandey Vinay , Jain Divya , Tripathi Anjali , Srivastava Shivangi , Tripathi Gyanendra
Published: September 2024

Wild food plants (WFPs) grow naturally and are essential components of the diet and conventional food chain. These plants are underutilized despite being nutritious and highly bio-active compounds. Wild food consumption has declined over the last generation owing to life-style changes and lower availability, and it is still consumed by marginalized communities. WFPs are available in a broad range of species and flavors that can help diversify the diet and make meals more enjoyable. Therefore, enhancing the availability and consumption of pro-cessed foods manufactured from wild plants is necessary. The increased use of processed prod-ucts formulated from edible wild plants can improve nutrition and protect ecological and cultural varieties. They are high in vitamins and micro-and macronutrients, which are essential for com-munities particularly vulnerable to malnutrition and imbalanced health. As plants develop natu-rally without the use of pesticides or other fertilizers, wild-food plants are typically considered more sustainable than commercial crops. Wild plants contain phytochemicals with various phar-macological and biological properties. Consuming WFPs should be done with caution and mod-eration, because some wild plants can be hazardous or harmful if consumed in large quantities or without adequate preparation. This review discusses various emerging technologies for han-dling wild food plants, the health benefits of these wild food plants, the effect of processing on reducing ant nutritional components, pharmaceutical potential, and consumers’ overall percep-tions of wild food plants.
ANALISIS STRATEGI PENGHIMPUNAN DANA INFAQ MELALUI PROGRAM SAFARI BERKISAH DI YAYASAN DANA SOSIAL AL FALAH MALANG
Authors: Puspita Sari Anggie , Anggraini Ika Khusnia
Published: September 2024

Many infaq management institutions such as Baznas and LAZ have been established. These institutions certainly need a strategy in collecting for the sustainability of the institution and realizing its distribution program. This study aims to determine the implementation of the Safari Berkisah program as a method of collecting infaq at YDSF Malang, and the impact of the Safari Berkisah program on YDSF Malang and stakeholders. The gap between this research and the research that has been done lies in the object of research where in previous studies no one has made Safari Berkisah as the object of research.  The method used in this research is a qualitative method with a case study approach. From this research it is known that the implementation of the Safari Berkisah program at YDSF Malang is in accordance with the stages of fundraising strategy and the program has a positive impact on YDSF Malang and stakeholders. The results of this study are expected to be input for the Al Falah Social Fund Foundation Malang regarding the Safari Berkisah method as one of its collection methods, and can be taken into consideration for zakat, infaq, and alms management institutions in carrying out collection activities, especially through Safari Berkisah activities.
FAKTOR – FAKTOR YANG MEMPENGARUHI KEPUTUSAN KONSUMEN MEMILIH HOTEL SYARIAH
Authors: Pasya Shifa Aulia , Noor Iswan
Published: September 2024

The emergence of halal tourism aligned with Sharia principles has been a significant development in the tourism industry. One crucial aspect of this trend is the presence of Sharia-compliant hotels, which are increasingly competitive in the hospitality sector. This research aims to identify key factors influencing consumer choices when selecting Sharia-compliant hotels in Batu. Using a quantitative descriptive approach with Likert scale analysis, a sample of 160 participants was randomly selected from various respondents who had stayed in Sharia-compliant hotels in Batu. The research findings reveal that consumers' personal preferences in choosing Sharia-compliant hotels are primarily determined by location, religiosity, price, product quality, and lifestyle.
ANALISIS KINERJA BPR SYARIAH DI JAWA TIMUR: STUDI KASUS SEBELUM DAN SESUDAH PANDEMI COVID-19
Authors: Ubaidillah Muhammad Irfan , Al Muizzuddin Fazaalloh
Published: September 2024

The Covid-19 pandemic in Indonesia has had a noticeable impact on the economy, including the profitability of the Islamic People's Financing Bank (BPRS) in East Java, which provides financing to the public. The objective of this research is to determine the impact of Covid-19 on the profitability of Islamic BPRs in East Java, with a sample of 19 Islamic BPRs from the period 2017-2023, using panel data regression analysis techniques. The results of the conducted tests indicate that non-performing financing (NPF) has a negative but insignificant impact on profitability, while operating expenses (BOPO) have a significant negative impact on profitability. Financing-to-deposit ratio (FDR) has a significant positive impact on profitability, while capital adequacy ratio (CAR) has a positive but insignificant impact on profitability. Moreover, Covid-19 has a significant positive impact on the profitability of Islamic BPRs in East Java.
PENINGKATAN KESEJAHTERAAN PENERIMA MANFAAT YAYASAN BAITUL MAAL (YBM) PLN PERSPEKTIF MAQASHID SYARIAH
Authors: Firly Intan Putih Ramadhan  , Hascaryani Tyas Danarti
Published: September 2024

This study aims to analyze the empowerment of gerobak cahaya which is one of the flagship programs of YBM PLN Malang City in distributing and utilizing zakat funds in the form of productive zakat, linked to aspects of maqashid sharia. The reason this research is important is because no previous research has been found with similar objects, so new findings are needed that can be used as material for further research. This research uses a qualitative research method with a case study approach based on interviews, observation and documentation. From this research it is known that YBM PLN Malang City has made efforts to help improve the welfare of the community, especially the beneficiaries of the YBM PLN Malang City gerobak cahaya through the implementation of empowering gerobak cahaya. The resulting welfare impact shows that the beneficiaries of the Malang City gerobak cahaya are not yet fully prosperous according to maqashid sharia, because one of the elements of maqashid sharia, namely reason (al-aql) is not fulfilled.
ANALISIS PENGARUH PEMBIAYAAN MURABAHAH, MUDHARABAH, DAN MUSYARAKAH TERHADAP PROFITABILITAS BCA SYARIAH DENGAN PERAN COVID-19 SEBAGAI VARIABEL MODERASI
Authors: Hanifah Ishma Hanani  , Ika Khusnia Anggraini
Published: September 2024

The COVID-19 pandemic which ended in early 2023 affected many sectors throughout the world. Apart from the health sector, Islamic banking also experienced shocks. The problem to be studied in this research is the influence of murabahah, musyarakah and mudharabah financing on the profitability of BCA Syariah by including the role of Covid-19. The aim of this research is to obtain answers to whether these three types of financing partially affect BCA Syariah's profitability, whether the Covid-19 pandemic indirectly affects BCA Syariah's profitability or vice versa. Data analysis uses Moderated Regression Analysis (MRA) because it also considers the role of Covid-19 in this research. Based on the output of this research, the conclusion is that murabahah does not affect BCA Syariah's profitability, unlike mudharabah and musyarakah financing which contribute to increasing BCA Syariah's profitability. The Covid-19 pandemic variable moderates the influence of murabahah and musyarakah financing. However, the pandemic does not affect mudharabah financing activities at BCA Syariah.
PERAN BAZNAS INDONESIA DALAM UPAYA MENDUKUNG PROGRAM SDGS (STUDY CASE : POIN 1 NO POVERTY DAN 4 QUALITY EDUCATION DI INDONESIA)
Authors: Hasibuan Riyadi , Dwi Retno Widiyanti
Published: September 2024

The aim of this research is to find out the role of the National Zakat Amil Agency (BAZNAS) in supporting the Sustainable Development Goals (SDGs) Agenda in Indonesia, namely point 1 without poverty and point 4 quality education through superior programs owned by BAZNAS. This research method is qualitative research with a systematic literature approach using PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analysis). The reading sources used in this research were obtained from journals, books, books, magazines, newspapers, trusted websites, and other records that are relevant to the problems to be discussed. The research results from the articles analyzed show that there are programs owned by BAZNAS, in the SDGs problem point 1, namely without poverty, there is a mustahik empowerment program and for problem point 4, namely quality education, there is the Beasiswa Cendekia and Sekolah Cendekia programs. The existing programs show that BAZNAS has contributed to solving the problem of poverty and improving the quality of education in Indonesia, which is in line with the SDGs program points 1 and 4. However, several articles also state that the role of BAZNAS in achieving the SDGs goals has not been fully achieved, it is necessary there are several things that need to be improved and good cooperation between BAZNAS, the government and the community
PENGARUH LITERASI KEUANGAN SYARIAH, HEADING BEHAVIOR, DAN RELIGIUSITAS PADA GENERASI Z DAN MILENIAL TERHADAP MINAT INVESTASI DI PASAR MODAL SYARIAH
Authors: Harahap Anggriani Muliadin , Hascaryani Tyas Danarti
Published: September 2024

In recent years, the Indonesian capital market has continued to increase and is dominated by generation Z and millennials, both sharia and conventional capital markets. In this modern era, investing has become a trend. Therefore, the author examines whether Islamic financial literacy, herding behavior, and religiosity can influence the interest of generation Z and millennials to invest in the Islamic capital market. This type of research is quantitative research and data was collected from a questionnaire survey using 200 respondents. The data analysis method used is the Structural Equation Modeling (SEM) method with the Partial Least Squares (PLS) approach using SmartPLS software. The results of this research are that herding behavior and religiosity have a significant effect on the investment interest of generation Z and millennials in the sharia capital market, while sharia financial literacy has no significant effect. The implication of this research is that these three factors are taken into consideration by potential investors and readers when making investment plans. This research can contribute to the development of the Islamic capital market by providing a better understanding of the perceptions and interests of generation Z and millennials towards the Islamic capital market.
ANALISIS PENGARUH VARIABEL MAKROEKONOMI TERHADAP JAKARTA ISLAMIC INDEX (JII) (PERIODE 2011-2022)
Authors: Raffy Muhammad Raffy Nugraha , Iswan Noor
Published: September 2024

This research aims to analyze the influence of macroeconomic variables on the movement of the Jakarta Islamic Index (JII) during the period 2011-2022. The considered macroeconomic variables encompass economic growth, inflation, interest rates, exchange rates, and the Composite Stock Price Index (IHSG). The analytical method employed is regression analysis, complemented by classical assumption tests. The research findings indicate that inflation, interest rates, and IHSG significantly influence the movement of JII, while economic growth and exchange rates do not exhibit significant effects. The implications of these findings underscore the importance of considering macroeconomic factors in making investment decisions within the Sharia-compliant capital market, particularly concerning JII. However, it is essential to acknowledge certain limitations in this study, such as data constraints and generalization limitations. Therefore, the results should be interpreted cautiously, taking into account other potential factors that may impact the movement of JII.
ANALISIS KESEDIAAN MEMBAYAR (WILLINGNESS TO PAY) DENGAN PENDEKATAN CHOICE MODELLING (STUDY KASUS COBAN RONDO DAN COBAN TALUN
Authors: Safa'atin Ermi Safaatin , Shofwan
Published: September 2024

This study aims to answer several questions related to the choices made by visitors when choosing to visit between Coban Rondo and Coban Talun and their maximum WTP evaluation for conservation purposes.This study seeks to assess how the main environmental attributes of interest to researchers will determine tourists WTP for conservation purposes.The research approach used in this study is a quantitative approach with a descriptive approach. Determination of the number of samples used in this study is a linear time function. The results of research on the characteristics of respondents, respondents' perceptions, and analysis of factors influencing tourist visits to the Wendit Water Tourism Park using the Individual Travel Cost Method (ITCM) are mostly female with an age range between 21-40 years and the level of education is mostly from undergraduate strata 1 graduates and their equivalents. The results of the Willingnes To Pay calculation of visitors to the progress of the quality of the environment and the Coban Rondo and Coban Talun pariwsata places are Rp. 2,400.00 per person. With the average number of visitors who come to Coban is about 200 in 1 month, the economic value of the two coban will be around Rp.480,000.00 in a month.
PENGARUH UPAH MINIMUM KABUPATEN/KOTA (UMK) TERHADAP TINGKAT PENGANGGURAN TERBUKA (TPT) DAN KEMISKINAN
Authors: Silvia Luthfiyah Ghinastri  , Wildan Syafitri
Published: September 2024

The Municipal Minimum Wage Policy (UMK) aims to improve the welfare of workers/laborers and avoid the poverty trap. However, based on the theory of the “UMK” policy, it has a negative impact, it can increase unemployment and poverty. This study analyzes the influence of the UMK on TPT and poverty in West Java by considering the supporting variables, namely population, number of industries, investment. The type of data used is secondary which tested by using panel data regression analysis and processed with Stata 14.2. The results of the analysis show that the UMK has a positive effect on TPT, but the population, number of industries and investment have no effect on TPT. Then, the UMK has a negative effect on poverty, population has a positive effect on poverty, and the number of industries has a negative effect on poverty, while investment has no effect on poverty in West Java in 2017 – 2021.
Wychowawcza obecność polskich salezjanów w Wilnie 1924-1945. Zarys problematyki
Authors: Pietrzykowski Jan
Published: September 2024

Salezjanie przybyli do Wilna w 1924 r. i przejęli do obsługi koedukacyjne placówki opiekuńcze prowadzone przez ks. prałata Karola Lubiańca. Pierwszy dyrektor domu zakonnego, ks. dr Wojciech Balawajder zlikwidował koedukacyjny charakter tych dzieł dobroczynnych. Salezjanie z chłopcami pozostali przy ul. Dobrej Rady i dodatkowo obsługiwali kościół Opatrzności Bożej. Dziewczęta umieszczono przy ul. Stefańskiej w pobliżu dworca kolejowego. W 1928 r. salezjanom oddano do użytku kościół św. Stefana, przy którym powstał osobny dom zakonny. Księża i klerycy prowadzili oratorium, uczyli religii w szkołach, pełnili posługę w więzieniach, studiowali na Uniwersytecie Stefana Batorego. W czasie drugiej wojny światowej zakonnicy prowadzili ograniczoną działalność duszpasterską i angażowali się w nauczanie na tajnych kompletach. Podczas okupacji litewskiej, sowieckiej i niemieckiej salezjanie zostali usunięci z placówki przy ul. Dobrej Rady i byli internowali w domach salezjanów litewskich. Po drugiej wojnie światowej większość polskich salezjanów wróciła  z Wilna i z Wileńszczyzny do Polski.
The Role of Microsurgery and Fluorescent-reporter Genes in Establishing Mouse Models for Real-Time Imaging of Metastatic Cancer-Cell Trafficking and Colony Formation: A Revolutionary and Disruptive Technology for Metastasis Research
Authors: MORINAGA SEI , YAMAMOTO NORIO , YAMAUCHI KENSUKE , HAYASHI KATSUHIRO , KIMURA HIROAKI , MIWA SHINJI , IGARASHI KENTARO , HIGUCHI TAKASHI , TSUCHIYA HIROYUKI , DEMURA SATORU , HOFFMAN ROBERT M.
Published: September 2024

The field of experimental microsurgery was pioneered by the great microsurgeon Sun Lee, who developed the foundation of transplant surgery in the clinic. Dr Lee also played a seminal role in introducing microsurgery to establish mouse models of cancer. In 1990, at the age of 70, Dr Lee demonstrated microsurgery techniques to the mouse-model team at AntiCancer Inc., leading to the development of the surgical orthotopic implant (SOI) technique and the first orthotopic mouse models of cancer that metastasized in a pattern similar to clinical cancer. At the beginning of the present century, one of us (NY) from Kanazawa University School of Medicine became a visiting scientist at AntiCancer to learn SOI and develop mouse models of cancer using cancer cells expressing fluorescent reporter genes, such as green fluorescent protein (GFP) and red fluorescent protein (RFP), in order to image metastatic cancer cells trafficking in real time. Since then, a total of eight young surgeons from Kanazawa University have been visiting researchers at AntiCancer, developing SOI mouse models of cancer to visualize cancer cells in vivo, tracking all stages of metastasis in real time. The present perspective review summarizes this seminal work, which has revolutionized the field of metastasis research.
Imaging Transgenic Nude Mice Expressing Spectrally-distinct Fluorescent Reporters Emitting From Blue to Far Red Light With One Instrument With Single-nanometer-tuning of Laser-excitation Fluorescence
Authors: MIZUTA KOHEI , REYNOSO JOSE , GALLAGHER SEAN , WANG APRIL , CHANG NEIL , MORINAGA SEI , SATO MOTOKAZU , KANG BYUNG MO , HOFFMAN ROBERT M.
Published: September 2024

Background/Aim: Transgenic nude mice expressing green fluorescent protein (GFP), red fluorescent protein (RFP), or cyan fluorescent protein (CFP) were previously developed by our laboratory, AntiCancer Inc. In the present study, we demonstrate imaging of the GFP, RFP, or CFP nude mice with single-nanometer-tuning laser fluorescence excitation with a single instrument. Materials and Methods: Female transgenic C57/B6 nude GFP, RFP, and CFP mice aged six weeks were used. The images were obtained using the UVP Biospectrum Advanced system (Analytik Jena US LLC) with excitation at 480 nm and peak emission at 513 nm for GFP; 520 nm and 605 nm, respectively, for RFP; and 405 nm and 480 nm, respectively, for CFP. Results: For each color transgenic fluorescent mouse, images without background could be obtained individually with the UVP Biospectrum Advanced system. Conclusion: Using a single instrument, brilliant and well-defined images of GFP, RFP, and CFP mice were obtained with single-nanometer-tuning laser fluorescence excitation. This imaging system will be used in future studies to analyze cancer cells in the colored mice that are spectrally distinct in order to determine how stromal cells and cancer interact in the tumor microenvironment.
Atezolizumab Plus Bevacizumab Treatment for Unresectable Hepatocellular Carcinoma: Real-life Experience from a Single Tertiary Centre in Spain and ALBI Score as a Survival Prognostic Factor
Authors: BALLESTER MARÍA PILAR , ABRIL CARLOS , MERINO VÍCTOR , ALÓS MANUEL , SEGARRA GLORIA , TOSCA JOAN , MONTÓN CRISTINA , CASASUS NURIA , LLUCH PALOMA
Published: September 2024

Background/Aim: Atezolizumab/bevacizumab (atez/bev) has been established as first-line systemic treatment for hepatocellular carcinoma (HCC). However, concerns regarding safety and efficacy have been raised, and no biomarkers to predict response have yet been identified. We aimed to evaluate the real-life experience of atez/bev in a Spanish tertiary hospital and identify factors associated with overall survival (OS). Patients and Methods: A prospective study of consecutive patients with HCC treated with atez/bev was conducted from December 2020 to December 2022. Efficacy was assessed through OS and progression-free survival (PFS), whereas safety was evaluated based on adverse events (AE). Twenty-three patients were included; 91% were males with a mean of 70 years. Thirteen patients were classified as having BCLC-C. Results: The median treatment duration was 126 days (range=567). Median OS was 381 days (95%CI=205-557) with a cumulative probability of death of 13%, 30%, and 49% at 3, 6 and 12-month follow-up, respectively. The only factor associated with OS was the ALBI score (HR=5.03; 95%CI=1.3-19.1), which showed an AUROC of 0.906 (95%CI=0.78-1.00) for the risk of death at 18 months follow up. Median PFS was 141 days (95%CI=110-172). Twenty (86.9%) patients experienced AE, which in nine (39.1%) cases led to the definitive discontinuation of the treatment, four of them (17.4%) due to an AE grade 5. Conclusion: The initial experience with atez/bev at our center demonstrated poorer outcomes compared to the original trial (IMbrave150). A careful assessment of the ALBI score may serve as a crucial factor in the selection of systemic treatment for patients with HCC.
Interval to Recurrence Affects Survival in Recurrent Head and Neck Squamous Cell Carcinoma
Authors: MATSUO MIOKO , HASHIMOTO KAZUKI , KOGO RYUNOSUKE , SATO MASANOBU , MANAKO TOMOMI , NAKAGAWA TAKASHI
Published: September 2024

Background/Aim: Approximately half of head and neck squamous cell carcinoma (HNSCC) cases recur, with most recurrences occurring within the first two years after treatment. Although it has been suggested that the interval to recurrence after radical treatment is associated with prognosis in patients with HNSCC, further investigation is needed. Patients and Methods: Patients diagnosed with HNSCC at Kyushu University Hospital were retrospectively analyzed (n=500). Early recurrence (ER) was defined as disease recurrence within six months of radical treatment, whereas late recurrence (LR) was defined as recurrence after more than six months. Continuous variables were assessed using the Mann–Whitney U-test and categorical variables were assessed using Fisher’s exact test. Results: A total of 234 patients experienced recurrence, with 110 and 124 patients experiencing ER (recurrence within two to six months) and LR (recurrence after six months), respectively. Multivariate analyses identified two independent risk factors for poor prognosis: ER [hazard ratio (HR)=3.200, 95% confidence interval (CI)=1.570-6.521, p=0.001] and absence of radiotherapy (HR=0.374, 95%CI=0.191-0.733, p=0.004). In patients with recurrent HNSCC, a short interval to recurrence is a risk factor for poor prognosis and survival. This study demonstrated the prognostic value of ER in these patients. Conclusion: The selection of treatment for patients with recurrent head and neck squamous cell carcinoma should consider the timing of recurrence, the initial treatment regimen, and the strategy for changing salvage therapy depending on the recurrence status.
Técnicas de multiplicación rápida de semilla de yuca de alta calidad
Authors: Espitia Montes Amaury Aroldo , Bohórquez Chaux Adriana , Rosero Alpala Elvia Amparo , López Rebolledo Leonardo Andrés , Dorado Valencia Carlos , Escobar Pérez Roosevelt Humberto , Támara Morelos Ricardo Enrique , Montejo Núñez Luis Giovanni Mauricio , Regino Hernández Sol Mara , Pérez Pazos Jazmín Vanessa , Fuentes Cassiani Deimer Alberto , García Herazo Jorge Luis , Araujo Vásquez Hernando Alberto , Rodríguez Henao Eberto , Aguilera Arango Germán Andrés , Garavito Morales Lina Vanessa
Published: September 2024

Este manual presenta esquemas de propagación rápida de semilla de yuca en túneles de PVC, en tubo galvanizado o en campo usando miniestacas. Estas tecnologías buscan la disponibilidad de semilla de calidad de un ciclo a otro, con lo cual, en condiciones controladas, se genera una tasa de multiplicación superior a la obtenida en campo en condiciones convencionales. Así, se describe el proceso de obtención de semilla de calidad desde la indexación hasta la categoría de semilla certificada, según la normativa vigente del Instituto Colombiano Agropecuario (ICA). Además, se detalla el paso a paso de los dos métodos, con el fin de que puedan ser replicados en diferentes condiciones. La información se entrega para fortalecer el esquema de producción de semilla de yuca de calidad en Colombia.