bluuebunny/crossref_metadata_2025 huggingface dataset:
Family socioeconomic status and the parent–child relationship in Chinese adolescents: the multiple serial mediating roles of visual art activities
Authors: Gao Chunhai , Tadesse Endale , Khalid Sabika
Published: May 2022

Background

In light of the recent policy reform in China, the present study aims to investigate the potential impact of family SES on the quality of the parent–child relationship (PCR) through the serial mediating role of participation in organized visual art activities in privately owned centers (VAA1) and parent-supervised visual art activities (VAA2) across genders.

Method

A cross-sectional study was conducted in anonymous province located in the southwestern part of China. A total of 1624 primary school students aged 7 to 14 years were recruited through a random sampling technique. Subsequently, anonymous survey responses were taken from all students. Multiple serial mediation analysis was performed by using AMOS 21.0 software to attain the primary aim of the study.

Result

According to the total sample model result, SES has a significant direct effect on the parent–child relationship (β = 0.47, p < 0.001), children’s participation in VAA1 (β = 0.197, p < 0.001) and VAA2 (β = 0.269, p < 0.001). Moreover, the mediation model result indicates that SES has a stronger indirect effect on the parent–child relationship through a mediating role of VAA1 (βgirl = 0.08, p < 0.01; βboys = 0.04, p < 0.01) for female than male samples. However, the mediating effect of VVA2 between SES and the parent–child relationship in the female (β = 0.08, p < 0.001) and male (β = 0.08, p < 0.01) models is equal, although female gender is highly significant. Ultimately, the serial mediation analysis result affirms that the serially mediating role of VAA1 and VAA2 between SES and the parent–child relationship was equal across genders (βboys = 0.001, p < 0.001; βgirls = 0.001, p < 0.001).

Conclusion

Unlike previous studies, this study’s multigroup model shows that both male and female children can equally restore their relationship with their parents by having substantial participation in both VAA1 and VAA2. Thus, parents ought to play the main role in facilitating and supporting children’s visual art activities without parenting that shows a gender bias.
Lifestyle factors and psychological well-being: 10-year follow-up study in Lithuanian urban population
Authors: Sapranaviciute-Zabazlajeva Laura , Sileikiene Lolita , Luksiene Dalia , Tamosiunas Abdonas , Radisauskas Ricardas , Milvidaite Irena , Bobak Martin
Published: May 2022

Background

Several lifestyle behaviours, including physical activity, smoking, alcohol consumption, nutrition habits, and social activity have been associated with psychological well-being (PWB). However, their effect on PWB prospectively has been less studied. The aim of the present study was to evaluate the influence of lifestyle factors on higher future PWB during the 10-year follow-up of middle-aged and elderly urban population.

Methods

In the baseline survey (2006 to 2008), 7115 men and women 45–72 years of age were examined within the framework of the international study Health, Alcohol and Psychosocial Factors in the Eastern Europe (HAPIEE). In the follow-up survey (in 2016), which was performed among all 6210 participants who survived till that year, 4266 individuals participated responding to postal questionnaires. PWB was assessed by a CASP-12 questionnaire. The lifestyle behaviours, including smoking and nutrition habits, alcohol consumption, social and physical activity, were evaluated by the questionnaire. Multivariable logistic regression models were applied for statistical data analysis.

Results

After accounting for several potential confounders, healthy levels of lifestyle behaviours were associated with higher PWB after 10-year follow-up. Never-smokers in men and former smokers in women had higher PWB by 43 and 67% odds respectively in comparison with smokers. Physical activity in women and high social activity both in men in women was positively related to higher PWB. More frequent fresh vegetable and fruit consumption was associated with higher odds of higher PWB (odds ratio 1.57 in men and 1.36 in women, p < 0.05) compared to less frequent consumption of such food groups. Dose-response relationship between increasing number of healthy lifestyle factors and higher PWB was determined both in men and women.

Conclusions

Lifestyle factors such as never smoking and former smoking, high social activity, and more frequent fresh vegetable and fruit consumption increased the odds of higher PWB over 10 years of follow-up in men and women groups. The increase of the protective health behaviour score was directly associated with the odds of higher PWB.
Effectiveness of an online application of the health action process approach (HAPA) theory on oral hygiene intervention in young adults with fixed orthodontic appliances: a randomized controlled trial
Authors: Wu Weizi , Hu Lulu , Chen Yihan , Cao Feiran , Ding Sixie , Wu Tingting , Xu Jianguang
Published: May 2022

Background

This randomized controlled trial aimed to evaluate the effectiveness of an online application based on HAPA theory on oral hygiene promotion in young adults with fixed orthodontic appliances.

Methods

A WeChat mini-program (called “Clean Teeth”) based on HAPA theory was designed beforehand to improve oral-health behaviors and oral hygiene, and 44 participants aged 17–29 with fixed orthodontic appliances were recruited. Participants of the experimental group (n = 22) received the “Clean Teeth” mini-program, in addition to care as usual, and the control group (n = 22) only received routine oral health education. Data were collected during three orthodontic check-ups: baseline (T0), 6 weeks of follow-up (T1), and 12 weeks of follow-up (T2). All participants completed questionnaires assessing oral health behaviors and the psychosocial factors of the HAPA model and accepted the clinical examinations involving the dental plaque index and the gingival bleeding index.

Results

After a 12-week intervention, the plaque index and gingival bleeding index in the experimental group were significantly lower than that in the control group. The psycho-social parameters of social effects, expected outcomes, and action control were improved significantly after treatment, among which social effects increased significantly only in the experimental group but not in the control group.

Conclusions

The HAPA theory-based mini-program had positive effects on oral-health behavior promotion and oral hygiene among young adults with fixed orthodontic appliances.

Trial registration This study was retrospectively registered in the Chinese Clinical Trial Registry, with the number CTR2200056731, dated 12/02/2022. http://www.chictr.org.cn/index.aspx.
‘’We usually choose safety over freedom’’: results from focus groups with professional caregivers in long-term dementia care
Authors: Portegijs Suzanne , van Beek Adriana Petronella Anna , van Tuyl Lilian Huibertina Davida , Wagner Cordula
Published: May 2022

Background

People with dementia living in nursing homes are mostly sedentary, which is a consequence of various personal, environmental and organizational factors. Until now, studies on physical activity and safety in dementia have focused on residents and caregivers from the viewpoint of (individual) care provision and health benefits. There has been little to no focus on the possible influence of group dynamics between care providers with regard to physical activity and safety. The aim of this study is to gain more insight into the viewpoints and intentions of groups of professional caregivers towards safety and physical activity and the potential influence of the group-oriented setting in long-term care on physical activity of individual residents.

Methods

A qualitative study comprising three focus group discussions including professional caregivers (n = 15) was conducted within two long-term care organizations in the Netherlands. Focus group discussions were structured using an interview guide derived from a preliminary framework, based on existing literature and complemented with clinical expertise.

Results

Seven themes could be derived from the focus group discussions that influence physical activity and safety: 1) Individual health and abilities; 2) Balancing physical activity and safety; 3) Physical restraints; 4) Group interests versus the individual interests; 5) Organization of care and physical environment; 6) Perceived responsibilities and tasks of professional caregivers and 7) Change is challenging.

Conclusions

Due to multiple influencing factors, the balance for care providers in long-term care generally tends towards safety over physical activity. Furthermore, in order to stimulate physical activity various limitations are experienced, including the organization of care, the general health of the residents and difficulty to achieve changes in daily care. Most importantly, the group interests of both the professional caregivers and the residents have a substantial influence on the incorporation of physical activity in daily care.
Genomic features of Chinese small cell lung cancer
Authors: Liu Jun , Zhao Zhuxiang , Wei Shuquan , Li Binkai , Zhao Ziwen
Published: May 2022

Background

Small cell lung cancer (SCLC) is an aggressive disease with poor survival. Although molecular and clinical characteristics have been established for SCLC in western patients, limited investigation has been performed for Chinese SCLC patients.

Objective

In this study, we investigated the genomic features of Chinese SCLC patients.

Methods

A total of 75 SCLC patients were enrolled. Genomic alterations in 618 selected genes were analyzed by targeted next-generation sequencing.

Results

Here, we showed that TP53 (77.30%) and RB1 (30.70%) were the most prevalent genes alterations, followed by KMT2D, ALK, LRP1B, EGFR, NOTCH3, AR, CREBBP, ROS1, and BRCA2. And the most common genetic alterations were enriched in the cell cycle signaling pathway (84.00%) of Chinese SCLC patients. DNA damage repair (DDR) pathway analysis showed that the most frequently enriched DDR pathways were fanconi anaemia (FA, 29.41%) and homology recombination (HR, 21.57%). Notably, 9.33% SCLC patients in our cohort had pathogenic or likely pathogenic germline gene variants. Compared with the U Cologne cohort, a higher prevalence in EGFR, AR, BRCA2, TSC1, ATXN3, MET, MSH2, ERBB3 and FOXA1 were found in our cohort; while compared to the data from the Johns Hopkins cohort, a higher mutated frequency in TP53, KMT2D, ALK, and EGFR were found in our cohort. Moreover, a significant association was found between high tumor mutation burden (TMB) and mutations involved in TP53, CREBBP, EPHA3, KMT2D, ALK and RB1. Approximately 33.33% of patients with SCLC harbored at least one actionable alteration annotated by OncoKB, of which one patient had alterations of level 1; seventeen patients had level 3; fifteen patients possessed level 4.

Conclusion

Our data might provide an insightful meaning in targeted therapy for Chinese SCLC patients.
Identifying Alzheimer’s genes via brain transcriptome mapping
Authors: Baik Jae Young , Kim Mansu , Bao Jingxuan , Long Qi , Shen Li ,   Alzheimer’s Disease Neuroimaging Initiative
Published: May 2022

Background

Alzheimer’s disease (AD) is one of the most common neurodegenerative disorders characterized by progressive decline in cognitive function. Targeted genetic analyses, genome-wide association studies, and imaging genetic analyses have been performed to detect AD risk and protective genes and have successfully identified dozens of AD susceptibility loci. Recently, brain imaging transcriptomics analyses have also been conducted to investigate the relationship between neuroimaging traits and gene expression measures to identify interesting gene-traits associations. These imaging transcriptomic studies typically do not involve the disease outcome in the analysis, and thus the identified brain or transcriptomic markers may not be related or specific to the disease outcome.

Results

We propose an innovative two-stage approach to identify genes whose expression profiles are related to diagnosis phenotype via brain transcriptome mapping. Specifically, we first map the effects of a diagnosis phenotype onto imaging traits across the brain using a linear regression model. Then, the gene-diagnosis association is assessed by spatially correlating the brain transcriptome map with the diagnostic effect map on the brain-wide imaging traits. To demonstrate the promise of our approach, we apply it to the integrative analysis of the brain transcriptome data from the Allen Human Brain Atlas (AHBA) and the amyloid imaging data from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) cohort. Our method identifies 12 genes whose brain-wide transcriptome patterns are highly correlated with six different diagnostic effect maps on the amyloid imaging traits. These 12 genes include four confirmatory findings (i.e., AD genes reported in DisGeNET) and eight novel genes that have not be associated with AD in DisGeNET.

Conclusion

We have proposed a novel disease-related brain transcriptomic mapping method to identify genes whose expression profiles spatially correlated with regional diagnostic effects on a studied brain trait. Our empirical study on the AHBA and ADNI data shows the promise of the approach, and the resulting AD gene discoveries provide valuable information for better understanding biological pathways from transcriptomic signatures to intermediate brain traits and to phenotypic disease outcomes.
The DNA/RNA helicase DHX9 contributes to the transcriptional program of the androgen receptor in prostate cancer
Authors: Chellini Lidia , Pieraccioli Marco , Sette Claudio , Paronetto Maria Paola
Published: May 2022

Background

Prostate cancer (PC) is the most commonly diagnosed male malignancy and an important cause of mortality. Androgen deprivation therapy is the first line treatment but, unfortunately, a large part of patients evolves to a castration-resistant stage, for which no effective cure is currently available. The DNA/RNA helicase DHX9 is emerging as an important regulator of cellular processes that are often deregulated in cancer.

Methods

To investigate whether DHX9 modulates PC cell transcriptome we performed RNA-sequencing analyses upon DHX9 silencing in the androgen-responsive cell line LNCaP. Bioinformatics and functional analyses were carried out to elucidate the mechanism of gene expression regulation by DHX9. Data from The Cancer Genome Atlas were mined to evaluate the potential role of DHX9 in PC.

Results

We found that up-regulation of DHX9 correlates with advanced stage and is associated with poor prognosis of PC patients. High-throughput RNA-sequencing analysis revealed that depletion of DHX9 in androgen-sensitive LNCaP cells affects expression of hundreds of genes, which significantly overlap with known targets of the Androgen Receptor (AR). Notably, AR binds to the DHX9 promoter and induces its expression, while Enzalutamide-mediated inhibition of AR activity represses DHX9 expression. Moreover, DHX9 interacts with AR in LNCaP cells and its depletion significantly reduced the recruitment of AR to the promoter region of target genes and the ability of AR to promote their expression in response to 5α-dihydrotestosterone. Consistently, silencing of DXH9 negatively affected androgen-induced PC cell proliferation and migration.

Conclusions

Collectively, our data uncover a new role of DHX9 in the control of the AR transcriptional program and establish the existence of an oncogenic DHX9/AR axis, which may represent a new druggable target to counteract PC progression.
Machine learning and comparative genomics approaches for the discovery of xylose transporters in yeast
Authors: Fiamenghi Mateus Bernabe , Bueno João Gabriel Ribeiro , Camargo Antônio Pedro , Borelli Guilherme , Carazzolle Marcelo Falsarella , Pereira Gonçalo Amarante Guimarães , dos Santos Leandro Vieira , José Juliana
Published: May 2022

Background

The need to mitigate and substitute the use of fossil fuels as the main energy matrix has led to the study and development of biofuels as an alternative. Second-generation (2G) ethanol arises as one biofuel with great potential, due to not only maintaining food security, but also as a product from economically interesting crops such as energy-cane. One of the main challenges of 2G ethanol is the inefficient uptake of pentose sugars by industrial yeast Saccharomyces cerevisiae, the main organism used for ethanol production. Understanding the main drivers for xylose assimilation and identify novel and efficient transporters is a key step to make the 2G process economically viable.

Results

By implementing a strategy of searching for present motifs that may be responsible for xylose transport and past adaptations of sugar transporters in xylose fermenting species, we obtained a classifying model which was successfully used to select four different candidate transporters for evaluation in the S. cerevisiae hxt-null strain, EBY.VW4000, harbouring the xylose consumption pathway. Yeast cells expressing the transporters SpX, SpH and SpG showed a superior uptake performance in xylose compared to traditional literature control Gxf1.

Conclusions

Modelling xylose transport with the small data available for yeast and bacteria proved a challenge that was overcome through different statistical strategies. Through this strategy, we present four novel xylose transporters which expands the repertoire of candidates targeting yeast genetic engineering for industrial fermentation. The repeated use of the model for characterizing new transporters will be useful both into finding the best candidates for industrial utilization and to increase the model’s predictive capabilities.

Graphical Abstract
Spatial statistical and environmental correlation analyses on vector density, vector infection index and Japanese encephalitis cases at the village and pigsty levels in Liyi County, Shanxi Province, China
Authors: Liu Mei-De , Li Chun-Xiao , Cheng Jing-Xia , Zhao Tong-Yan
Published: May 2022

Background

In the eco-epidemiological context of Japanese encephalitis (JE), geo-environmental features influence the spatial spread of the vector (Culex tritaeniorhynchus, Giles 1901) density, vector infection, and JE cases.

Methods

In Liyi County, Shanxi Province, China, the spatial autocorrelation of mosquito vector density, vector infection indices, and JE cases were investigated at the pigsty and village scales. The map and Enhanced Thematic Mapper (ETM) remote sensing databases on township JE cases and geo-environmental features were combined in a Geographic Information System (GIS), and the connections among these variables were analyzed with regression and spatial analyses.

Results

At the pigsty level, the vector density but not the infection index of the vector was spatially autocorrelated. For the pigsty vector density, the cotton field area was positively related, whereas the road length and the distance between pigsties and gullies were negatively related. In addition, the vector infection index was correlated with the pigsty vector density (PVD) and the number of pigs. At the village level, the vector density, vector infection index, and number of JE cases were not spatially autocorrelated. In the study area, the geo-environmental features, vector density, vector infection index, and JE case number comprised the Geo-Environment-Vector-JE (GEVJ) intercorrelation net system. In this system, pig abundance and cotton area were positive factors influencing the vector density first. Second, the infection index was primarily influenced by the vector density. Lastly, the JE case number was determined by the vector infection index and the wheat area.

Conclusions

This study provided quantitative associations among geo-environmental features, vectors, and the incidence of JE in study sties, one typical northern Chinese JE epidemiological area without rice cultivation. The results highlighted the importance of using a diverse range of environmental management methods to control mosquito disease vectors and provided useful information for improving the control of vector mosquitoes and reducing the incidence of JE in the northern Chinese agricultural context.

Graphical Abstract
Effect of isometric exercise on blood pressure in prehypertensive and hypertensive individuals: protocol for a systematic review and meta-analysis of randomized controlled trials
Authors: de Oliveira Patrícia Caetano , Lehnen Alexandre M. , Waclawovsky Gustavo
Published: May 2022

Background

Systemic arterial hypertension (HTN) is the leading risk factor of cardiovascular disease death. Lifestyle changes are key for the prevention and management of HTN. Regular aerobic exercise training is recommended as part of the management of HTN, and dynamic resistance exercise should be prescribed as an adjuvant to aerobic training. Recent evidence points to the potential benefits of isometric resistance training in reducing blood pressure (BP). Yet, the hypotensive effect of isometric exercise in prehypertensive and hypertensive individuals is not fully understood. Thus, we will examine the effect of isometric exercise in prehypertensive and hypertensive individuals through a systematic review and meta-analysis.

Methods

Our systematic review study will include randomized controlled trials (RCTs) selected from the electronic databases MEDLINE (PubMed), Cochrane, LILACS, EMBASE, Web of Science, and PEDro published in English, Spanish, and Portuguese languages. We will follow the PRISMA-P (Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols) and PICOS framework. Our search will involve studies with both male and female participants aged 18 years or more diagnosed with prehypertension or HTN performing one session of isometric exercise (acute effect) or isometric exercise training (chronic effect) compared to a control group (no exercise). We will use the Cochrane Risk of Bias 2 (RoB 2) tool to evaluate the quality of the studies and RStudio software (v1.3.959 for Windows) for statistical analyses.

Discussion

A meta-analysis of a homogeneous sample of prehypertensive and hypertensive individuals involving isometric handgrip exercise alone can further support previous findings and improve our understanding and recommendations for the management of these populations.

Systematic review registration

PROSPERO CRD42020213081.
The importance of N6-methyladenosine modification in tumor immunity and immunotherapy
Authors: Zhang Ze , Liu Furong , Chen Wei , Liao Zhibin , Zhang Wanguang , Zhang Bixiang , Liang Huifang , Chu Liang , Zhang Zhanguo
Published: May 2022

As the most common and abundant RNA modification in eukaryotic cells, N6-methyladenosine (m6A) modification plays an important role in different stages of tumor. m6A can participate in the regulation of tumor immune escape, so as to enhance the monitoring of tumor by the immune system and reduce tumorgenesis. m6A can also affect the tumor progression by regulating the immune cell responses to tumor in tumor microenvironment. In addition, immunotherapy has become the most popular method for the treatment of cancer, in which targets such as immune checkpoints are also closely associated with m6A. This review discusses the roles of N6-methyladenosine modification in tumor immune regulation, their regulatory mechanism, and the prospect of immunotherapy.

Graphical Abstract
Adverse childhood experiences among adults with eating disorders: comparison to a nationally representative sample and identification of trauma profiles
Authors: Rienecke Renee D. , Johnson Craig , Le Grange Daniel , Manwaring Jamie , Mehler Philip S. , Duffy Alan , McClanahan Susan , Blalock Dan V.
Published: May 2022

Background

Adverse childhood experiences (ACEs) are prevalent, impact long-term physical and mental health, and are associated with eating disorders (EDs) in adulthood. The primary objectives of the current study were: (1) to examine and compare ACEs between two samples: treatment-seeking adults, and a nationally representative sample of adults, (2) to characterize ACEs items and total scores across demographic and diagnostic information in adults seeking treatment for an ED, (3) to statistically classify ACEs profiles using latent class analysis, and (4) to examine associations between ACEs profiles and diagnosis.

Methods

This cross-sectional study assessed patients with a DSM-5 ED receiving treatment between October 2018 and April 2020 at the inpatient, residential, or partial hospitalization levels of care at one of two private ED treatment facilities. ACEs were assessed with the Adverse Childhood Experiences Survey at admission. Generalized linear models and Welch’s t-tests were used to compare ACEs in the current sample with national estimates. A latent class analysis was conducted to examine subgroups of ACEs responses, and differences in these classes by ED diagnoses were examined with multinomial logistic regression.

Results

Patients with EDs had significantly higher ACEs scores (M = 1.95, SD = 1.90) than the nationally representative sample (M = 1.57, SD = 4.72; t = 6.42, p < .001). Within patients with EDs, four latent classes of ACEs item endorsement were identified. Patients with other specified feeding or eating disorder (OSFED) and binge eating disorder (BED) were more likely to fall into the “Household ACEs” and “Abuse ACEs” groups, respectively, compared to anorexia nervosa—restricting subtype (AN-R).

Conclusions

Patients with EDs reported more ACEs than the nationally representative sample, and differences in total ACEs and latent class membership were found across ED diagnoses. The current study can inform the development of trauma-informed care for patients with EDs.
Enstatite chondrites: condensation and metamorphism under extremely reducing conditions and contributions to the Earth
Authors: Lin Yangting
Published: May 2022

Enstatite chondrites are a small clan of meteorites, only ~ 1% out of all meteorite collection. However, they are the most reduced meteorites and have almost identical isotopic compositions to those of the Earth, suggestive of significant contributions to the latter and other terrestrial planets. Enstatite chondrites contain a unique mineral inventory of sulfides of typical lithophile elements, Si-bearing metal, silicide and phosphide, which record the nebular processes and the thermal metamorphism in asteroidal bodies under extremely reducing environments. EH group is mainly characteristic of the higher Si content of metallic Fe–Ni and the higher MnS contents of sulfides than EL group, indicative of a more reducing condition than the latter. However, the fugacity pH2S could be the same in both EH and EL regions, because it was buffered by kamacite and troilite. The majority of sulfides condensed from the nebula, partially enclosing schreibersite micron-spherules formed probably by early melting. Another part of troilite, sphalerite and djerfisherite, intergrown with perryite, were produced via sulfidation of metallic Fe–Ni. Minor exotic components were also found in enstatite chondrites, including Ca-, Al-rich inclusions and FeO-rich silicate clasts. The Ca-, Al-rich inclusions are identical to those in carbonaceous chondrites except for the alteration under reducing environments, and the FeO-rich silicate clasts show reduction reactions, both suggestive of migration of dust in the protoplanetary disk. The highly reducing conditions (as C/O ratios) might be established via repeating evaporation and condensation of water ice and organic matter across the snow line along the protoplanetary disk, but need to find evidence. Another issue is the preservation of submicron-to-micron-sized presolar grains during high-temperature condensation of the major constituent minerals. After accretion, the parent bodies of EH and EL chondrites probably experienced distinct thermal histories, indicated by their distinct petrologic-type distributions and different correlations with the closure temperatures determined by the FeS contents of sulfides in contact with troilite.

The composition of (Mg, Mn, Fe)S, a key indicator for condensation and metamorphism of enstatite chondrites.
Curative resection after chemotherapy and chemoradiotherapy for postoperative recurrence of pancreatic tail cancer in the abdominal wall: a case report
Authors: Iio Shunya , Hozaka Yuto , Tanoue Kiyonori , Idichi Tetsuya , Fukuda Kousuke , Nakashima Taiki , Yasudome Ryutaro , Yamasaki Yoichi , Kawasaki Yota , Arigami Takaaki , Nakajo Akihiro , Higashi Michiyo , Mataki Yuko , Kurahara Hiroshi , Ohtsuka Takao
Published: May 2022

Background

Locoregional recurrence and metastasis to the liver, peritoneum, and lung are the most common recurrent patterns of pancreatic ductal adenocarcinoma (PDAC) after radical resection. Recurrence in the abdominal wall is extremely rare. Herein, we report our experience with a patient who had recurrent PDAC in the abdominal wall with long-term survival by means of multidisciplinary therapy.

Case presentation

A 76-year-old Japanese woman was diagnosed with resectable pancreatic tail cancer. She underwent distal pancreatectomy with regional lymphadenectomy after two cycles of gemcitabine plus S-1 as neoadjuvant therapy. She also received eight cycles of S-1 as adjuvant chemotherapy. Approximately 14 months after the initial surgery, imaging examinations identified a mass suggesting recurrence in the abdominal wall at the middle wound that involved the transverse colon. After two cycles of gemcitabine plus nab-paclitaxel, chemoradiotherapy (S-1 plus 45 Gy) and seven cycles of modified FOLFIRINOX (5-fluorouracil/leucovorin, irinotecan, and oxaliplatin) were administered. The patient did not develop any new recurrent lesions during chemotherapy and chemoradiotherapy. Therefore, the recurrent lesion in the abdominal wall and the involved transverse colon were resected. We confirmed the lack of peritoneal dissemination during surgery. Pathological examination revealed that the resected lesion was metastasis of primary PDAC, and the surgical margin was 1 mm. However, re-recurrence localized in the abdominal wall was detected 9 months later. The re-recurrent lesion was diagnosed as local recurrence of the first recurrent lesion. We performed a second resection of the abdominal wall using a femoral myocutaneous flap to achieve sufficient surgical margin. The pathological findings of the resected specimen were the same as those of the previous specimens, and the resection margin was negative. The patient’s postoperative course was uneventful. Seven years after the initial surgery and 3 years and 7 months after the third surgery, the patient is alive with no signs of recurrence.

Conclusions

Long-term survival could be achieved by radical resection with sufficient surgical margins for recurrence of PDAC in the abdominal wall if new other recurrent lesions, including peritoneal dissemination, are prevented through chemotherapy.
The impact of COVID-19 pandemic on sleep quality in healthcare workers in Turkey
Authors: Erdoğan Ayşegül , Berktaş Deniz Tuncel , Öksüz Ali Nuri , Şahin Ahmet Rıza , Koçyiğit Burhan Fatih
Published: May 2022

Background

The COVID-19 pandemic has caused serious concerns and psychological distress globally. Healthcare workers remain one of the most affected groups due to life threatening risks in addition to increased working hours and labor intensity. All these factors may affect sleep quality of this population. The aim of this study is to evaluate the sleep behaviors of healthcare professionals working in secondary and tertiary hospitals in a large population in Turkey and to show how sleep quality is affected during the pandemic process using the easily applicable Jenkins Sleep Scale (JSS). The population of this cross-sectional descriptive study consists of two pandemic hospitals determined in Kahramanmaraş province. In our questionnaire, we asked subjective sleep quality, sleep time, time to fall asleep, total sleep time, and medication use. We also used JSS Turkish version (JSS-TR) to assess sleep quality and the Epworth Sleepiness Scale (ESS) for increased daytime sleepiness.

Results

Healthcare workers who participated in our survey reported that they started to go to bed later, fell asleep later (mean: 41.75 ± 35.35 min), their total sleep time (mean: 6.67 ± 1.88 h) was shortened, and they needed medication to sleep more (5.7%) after the COVID-19 pandemic. During the COVID-19 pandemic, bedtime behavior after 24:00 decreased from 80.1 to 43.9% of those who previously went to bed before 24:00. For those who went to bed after 24:00 before, it increased from 19.9 to 56.1%. In addition, sleep quality as assessed by subjective and JSS significantly deteriorated after the COVID-19 pandemic. Excessive daytime sleepiness increased. Those with ESS > 10 before and after COVID-19 were 3.9% and 14.1%, respectively (p < 0.001).

Conclusions

The COVID-19 pandemic has significantly adversely affected the sleep behavior and sleep quality of healthcare professionals. The JSS is an easily applicable scale for assessing sleep quality in large population studies.
Role of engrailed homeobox 2 (EN2) gene in the development of the cerebellum and effects of its altered and ectopic expressions
Authors: Poudel Phanindra Prasad , Bhattarai Chacchu , Ghosh Arnab , Kalthur Sneha Guruprasad
Published: May 2022

Background

Morphological organization, folial pattern formation and establishment of the neural circuitry within the cerebellum are the important events taking place during the development of the cerebellum. Expression of engrailed homeobox 2 (EN2) gene plays an essential role in taking place of these events in the developing cerebellum.

Main body

A search was performed by following the PRISMA guidelines to review the role of the EN2 gene in the development of the cerebellum. Human and animal in vivo and in vitro studies showed that expression of the EN2 gene maintains the normal development of the cerebellum, morphological organization, cerebellar foliation, fissure formation, establishment of the afferent topography, molecular pattern formation and patterned gene expression in the developing cerebellum. Altered expression of the EN2 gene changes the morphology and folial pattern of the cerebellum, whereas its activation rescues these defects. EN2 gene polymorphism is reported as a susceptible cause for autism spectrum disorder (ASD). Ectopic expression of EN2 gene may result cancer and it also may play anti-oncogenic role depending on the organ of its expression.

Conclusion

Expression of the EN2 gene is essential for the normal development of the cerebellum. Its altered expression results deformed cerebellum, polymorphysm is associated with autism and ectopic expression may results cancer.
Complementarity between success probability and coherence in Grover search algorithm
Authors: Pan Minghua , Situ Haozhen , Zheng Shenggen
Published: May 2022

Coherence plays a very important role in Grover search algorithm (GSA). In this paper, we define the normalization coherence

, where C is a coherence measurement. By virtue of the constraint of large N and Shannon's maximum entropy principle, a surprising complementary relationship between the coherence and the success probability of GSA is obtained. Namely,

, where C is in terms of the relative entropy of coherence and l
1 norm of coherence, t is the number of the search iterations in GSA. Moreover, the equation holds no matter either in ideal or noisy environments. Considering the number of qubits is limited in the recent noisy intermediate-scale quantum (NISQ) era, some exact numerical calculation experiments are presented for different database sizes N with different types of noises. The results show that the complementarity between the success probability and the coherence almost always holds. This work provides a new perspective to improve the success probability by manipulating its complementary coherence, and vice versa. It has an excellent potential for helping quantum algorithms design in the NISQ era.
Classical bridge functions in classical and quantum plasma liquids
Authors: Lucco Castello F. , Tolias P. , Dornheim T.
Published: May 2022

Bridge functions, the missing link in the exact description of strong correlations, are indirectly extracted from specially designed molecular dynamics simulations of classical one-component plasma liquids and accurately parameterized. Their incorporation into an advanced integral equation theory description of Yukawa one-component plasma liquids and a novel dielectric formalism scheme for quantum one-component plasma liquids lead to an unprecedented agreement with available molecular dynamics simulations and new ab initio path integral Monte Carlo simulations, respectively.
A systematic review of retinoic acid in the journey of spermatogonium to spermatozoa: From basic to clinical application
Authors: Margiana Ria , Pakpahan Cennikon , Pangestu Mulyoto
Published: May 2022

Background: Retinoic acid plays an essential role in testicular development and functions, especially spermatogenesis. We have reviewed the role of retinoic acid from basic (molecular) to clinical application.

Methods: A search was conducted in the online database including PubMed, Google Scholar, and Scopus for English studies published in the last eight years about this issue. We used the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines in assessing the studies we are going to investigate.

Results: Studies indicated that retinoic acid plays an essential role during pluripotent stem cell migration and lineage commitment, cell differentiation, apoptosis, stem cell number regulation, and maturation arrest in spermatogenic cells. Retinoic acid can also affect related protein expression and signaling pathways at different stages of spermatogenesis. Four studies have applied retinoic acid to humans, all of them in the single-arm observational study. The results look promising but need further research with more controlled study methods, randomization, and large samples.

Conclusions: This current systematic review emphasizes a novel retinoic acid mechanism that has not been well described in the literature previously on its functions during the first seven days of spermatogenesis, leading to new directions or explanations of male infertility cause and treatments as a part of reproductive health care.
The role of endothelial microparticles in children with asthma: Does it promote atherosclerosis progress?
Authors: Garina Lisa Adhia , Supriyatno Bambang , Yunus Faisal , Timan Ina Susianti , Hermani Bambang , Kekalih Aria , B. Kartasasmita Cissy , Suwarto Suhendro
Published: May 2022

Background: Asthma is a chronic inflammatory airway disease that has been linked to enhanced risks for atherosclerosis. The impact of asthma on cardiovascular disease risk in children is less well established. Asthma is defined by a history of respiratory symptoms and accompanied by airflow limitation, with heterogeneous clinical manifestations, and variability in the intensity of airway inflammation and remodeling. Endothelial microparticles (EMP) are biomarkers of endothelial dysfunction in several chronic diseases. Endothelial microparticles initiate an event of atherosclerotic plaque formation. Our study aimed to evaluate the role of endothelial microparticles in children with asthma.

Methods: A cross-sectional study was performed on a total of 50 children with asthma aged seven‒17 years. Children with asthma exacerbations, infections, and steroid use were excluded. Endothelial microparticles were measured with beads, and the fluorescence signal was measured using a flow cytometer. Pro-inflammatory cytokines were measured by enzyme-linked immunosorbent assay (ELISA) method.

Results: Based on the results from 50 asthmatic children, it was found that most children had a normal nutritional status, intermittent, and allergic asthma. The results of this study also showed that the circulation of asthmatic children found that the mean levels (µL) of CD31+/CD62E+, CD31+/CD62E-, and CD62E+/CD31- were 2,392.99 ± 7,787.94; 922.14 ± 1,554.03; 198.97 ± 387.68, with the average ratio of CD31+/CD62E+, which was ≤1.0 and identifies apoptosis. Path analysis results found that IL-6, TNF-α, and CD31+/CD62E- EMP played a role in peak expiratory flow rate (%PEFR, p = 0.02; p = 0.003; p = 0.04) in children with allergic asthma.

Conclusions: Endothelial microparticles play a role on peak expiratory flow rate (PEFR) in children with allergic asthma. Further study is needed to investigate the role of these biomarkers and their correlation with pro-inflammatory cytokines in the mechanism of atherosclerosis progression.
On the essence of cardiopulmonary resuscitation
Authors: Li Xiang
Published: May 2022

This article discusses that the essence of cardiopulmonary resuscitation (CPR) is energy transfer. The concept of occult cardiac arrest is proposed, and cardioversion after cardiac arrest is divided into spontaneous cardioversion and CPR according to the principle of energy transfer: the internal energy transmission of the body makes the cardioversion that is known as spontaneous cardioversion, and energy is mainly transfers from the outside leads to cardioversion, that is, CPR. The concept of domain energy in CPR is proposed, and it is argued that only energy transfer beyond the domain energy can lead to cardioversion in both spontaneous cardioversion and CPR. The principle of energy transfer is used to explain the common clinical electrocardiographic phenomena: dysrhythmia can occur when the energy required for the cardiac functions is insufficient, it is a manifestation of self-protection of the heart and the body, and the mechanism is further argued. It is demonstrated that serious cardiac events, such as ventricular fibrillation and cardiac arrest, are special types of cardiac self-protection. The mechanisms, general rules, and energy properties of modern CPR energy transfer are described, and the influence and interaction of energy transfer principle on the three states of time, space, and energy transfer during CPR are assessed, which will be significant for future research on CPR.
Design of a High Efficiency Switched-Capacitor (SC) DC-DC Converter
Authors: Khawarizmi Ahmad , Lee Lini
Published: May 2022

Portable electronic devices and miniaturized devices would require different operating voltages and load current which can be powered through DC-DC converter. In this paper, the proposed converter is based on a multiple topology of DC-DC converter circuit for more than one voltage gain regions using switched capacitor (SC) method. The post layout implementation showed that the high efficiency networks are achieved with low voltage drop and low internal resistance. The efficiency of 95% and 85% are shown, on the networks in the 1/2 and 2/3 voltage gain regions respectively, proving that this method is advantageous compared to other literature papers.
To Brush or Not to Brush: Product Rankings, Consumer Search, and Fake Orders
Authors: Jin Chen , Yang Luyi , Hosanagar Kartik
Published: May 2022

Brushing—online merchants placing fake orders of their own products—has been a widespread phenomenon on major e-commerce platforms. One key reason why merchants brush is that it boosts their rankings in search results. Products with higher sales volume are more likely to rank higher. Additionally, rankings matter because consumers face search frictions and narrow their attention to only the few products that show up at the top. Thus, fake orders can affect consumer choice. In our paper, we find that if brushing gets more costly for merchants (e.g., due to stricter platform policies), it may sometimes surprisingly harm consumers as it may only blunt brushing by the merchant who sells a more popular product but intensify brushing by the merchant selling a less popular product. If search is less costly for consumers (e.g., due to improved search technologies), it may not always benefit consumers, either. Moreover, the design of the ranking algorithm is critical: placing more weight on sales-volume-related factors may trigger a nonmonotone change in consumer welfare; tracking recent sales only as opposed to cumulative sales does not always dial down brushing and, in fact, may sometimes cause the merchant selling a less popular product to brush more.
EDUKASI MENGENAI STRATEGI PENGEMASAN PRODUK DAN PROSEDUR PEMBERIAN SP-IRTP BAGI UMKM DI DESA CIMARA KABUPATEN KUNINGAN
Authors: Hidayat Agi syarif , Kartono Kartono
Published: May 2022

UMKM memiliki kontribusi yang besar untuk perekonomian negara Indonesia, akan tetapi UMKM masih memiliki kelemahan. Berdasarkan analisis situasi pada UMKM di desa Cimara diketahui bahwa mayoritas UMKM belum memiliki kemasan yang berkualitas serta tidak memiliki SPP-IRT, permasalahan tersebut diduga karena masih kurangnya kesadaran pelaku UMKM mengenai pentingnya kemasan yang berkualitas dan SPP-IRT. Tujuan kegiatan PKM ini adalah untuk memberikan informasi mengenai strategi pengemasan produk yang baik serta prosedur pengurusan SPP-IRT. Kegiatan PKM dilaksanakan di Desa Cimara, Kecamatan Pasawahan Kabupaten Kuningan pada tanggal 12 Februari 2020. Metode pemberdayaan yang digunakan adalah ceramah. Jumlah peserta yang hadir 25 orang. Setelah mengikuti kegiatan ini peserta mendapatkan informasi mengenai strategi pengemasan produk yang baik serta informasi mengenai tahapan dan persyaratan mendapatkan SPP-IRT. Saran untuk kegiatan pengabdian selanjutnya adalah melakukan pendataan UMKM yang memiliki potensi bisnis yang baik, selanjutnya melakukan pendampingan secara intensif mengenai perbaikan kemasan serta melaksanakan pengurusan SPP-IRT secara kolektif di desa Cimara dengan melakukan kerja sama antara pihak UMKM, aparat desa Cimara, Akademisi serta Dinas Kesehatan Kabupaten Kuningan.
MENCIPTA TEKS SYAIR SEBAGAI BAHAN AJAR DI SMP
Authors: Wulandari Yosi , Purwanto Wachid Eko
Published: May 2022

Tujuan pelaksanaan kegiatan ini adalah upaya menggali dan memunculkan potensi di kalangan guru yang memiliki tugas sebagai pendidik dan pengajar sekaligus contoh bagi peserta didiknya. Metode kegiatan pengabdian masyarakat ini adalah metode pelatihan/praktik langsung di lapangan, yaitu praktik menulis teks syair. Â Hasil kegiatan pengabdian ini adalah guru-guru Bahasa Indonesia tingkat SMP di Kabupaten Bantul dapat meningkatkan kemampuan mencipta karya sastra. Selain itu, memiliki pemahaman terhadap cara pengembangan ide tulisan serta unsur syair. Setelah memiliki pemahaman tersebut, kegiatan pelatihan ini meluncurkan buku kumpulan teks syair karya guru-guru yang berjudul Ken Ratri dan Satria Batu Pualam. Dengan demikian, dapat disimpulkan bahwa kegiatan pengabdian berupa pelatihan penulisan teks syair ini dapat: (1) memperjelas motivasi dan orientasi bersastra sehingga terbentuk kejelasan sikap berkesenian sastra, (2) merangsang semangat (etos) kreatif para peserta pelatihan khususnya dan masyarakat pada umumnya, (3) memupuk minat dan bakat peserta pelatihan sehingga mereka memiliki kepekaan apresiasi dan kemampuan kritis/ekspresi serta pada giliran berikutnya mereka menjadi manusia yang memiliki kepribadian kreatif.
PENATAAN ADMINISTRASI KELEMBAGAAN RT 14 DESA BRAJAN, TAMANTIRTO KASIHAN BANTUL
Authors: Mutmainah, Nur Fitri , Mahendra Gerry Katon
Published: May 2022

This community service program is based on the fact that RT 14, Brajan, mostly consists of housing areas whose residents rent the houses. This situation creates difficulties in coordination and participants among the residents in various activities. That condition affects the comfort, discipline, cleanliness, and harmony among them. The method applied in this community service program is in the forms of coordination and deliberation towards the residents of RT 14. There are four activities conducted in this program: 1) strengthening organization by formulating job description to the boards of RT; 2) formulating rules and regulations in RT to motivate the residentsâ€™ active participations; 3) formulating resident database of RT 14; 4) creating empowering program for the residents. Hopefully, this community service program affects positive feedback to RT. 14 to be actively included in the development of Brajan, Tamantirto, Kasihan, Bantul.