bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessing Machine Learning Models for Gap Filling Daily Rainfall Series in a Semiarid Region of Spain
Authors: Bellido-Jiménez Juan Antonio , Gualda Javier Estévez , García-Marín Amanda Penélope
Published: September 2021

The presence of missing data in hydrometeorological datasets is a common problem, usually due to sensor malfunction, deficiencies in records storage and transmission, or other recovery procedures issues. These missing values are the primary source of problems when analyzing and modeling their spatial and temporal variability. Thus, accurate gap-filling techniques for rainfall time series are necessary to have complete datasets, which is crucial in studying climate change evolution. In this work, several machine learning models have been assessed to gap-fill rainfall data, using different approaches and locations in the semiarid region of Andalusia (Southern Spain). Based on the obtained results, the use of neighbor data, located within a 50 km radius, highly outperformed the rest of the assessed approaches, with RMSE (root mean squared error) values up to 1.246 mm/day, MBE (mean bias error) values up to −0.001 mm/day, and R2 values up to 0.898. Besides, inland area results outperformed coastal area in most locations, arising the efficiency effects based on the distance to the sea (up to an improvement of 63.89% in terms of RMSE). Finally, machine learning (ML) models (especially MLP (multilayer perceptron)) notably outperformed simple linear regression estimations in the coastal sites, whereas in inland locations, the improvements were not such significant.
The Impact of Climate Change on Urban Thermal Environment Dynamics
Authors: Žiberna Igor , Pipenbaher Nataša , Donša Daša , Škornik Sonja , Kaligarič Mitja , Bogataj Lučka Kajfež , Črepinšek Zalika , Grujić Veno Jaša , Ivajnšič Danijel
Published: September 2021

The human population is increasing. The ongoing urbanization process, in conjunction with climate change, is causing larger environmental footprints. Consequently, quality of life in urban systems worldwide is under immense pressure. Here, the seasonal characteristics of Maribor’s urban thermal environment were studied from the perspectives of surface urban heat island (SUHI) and urban heat island (UHI) A remote sensing thermal imagery time series and in-situ measurements (stationary and mobile) were combined with select geospatial predictor variables to model this atmospheric phenomenon in its most intensive season (summer). Finally, CMIP6 climate change scenarios and models were considered, to predict future UHI intensity. Results indicate that Maribor’s UHI intensity maximum shifted from winter to spring and summer. The implemented generalized additive model (GAM) underestimates UHI intensity in some built-up parts of the study area and overestimates UHI intensity in green vegetated areas. However, by the end of the century, UHI magnitude could increase by more than 60% in the southern industrial part of the city. Such studies are of particular concern, in regards to the increasing frequency of heat waves due to climate change, which further increases the (already present) heat stress in cities across the globe.
Development versus Adaptation? Facing Climate Change in Ca Mau, Vietnam
Authors: Giusto Bruno Di , Le Thi Minh Nghi , Nguyen Thanh Thao My , Nguyen Thi Thuy Hanh , Vu Nguyen Uyen My , Lavallee Joseph Paul
Published: September 2021

Climate change poses a dire threat to the Mekong River Delta, an important supplier of shrimp and rice to global markets. The southernmost province, Ca Mau, is threatened by sea level rise and land subsidence. Little is known of the expected combined impact of these processes, or of the perceptions of farmers towards these threats. This study first projected the combined effects using the most accurate extant elevation data. Next, to assess perceptions, we interviewed 53 farmers from six communes within the province. We found that 43% of the province could be at risk of submersion by 2030, and 75% by 2050. The interviews revealed that the farmers were largely unaware of the imminence of submersion and did not fully comprehend the nature and magnitude of the underlying processes. Constrained by the requirements of their developmental trajectory, they were focused on short term threats to their livelihood (weather, salinization, pollution). Consequently, far from adapting to the larger threats, they are engaged in practices, such as groundwater extraction for aquaculture, that are hastening the demise of the region. Their plight offers warnings to similar regions around the world. We hope that our findings can inform the development of future outreach programs.
Investigating Performance of cVEMP and oVEMP in the Identification of Superior Canal Dehiscence in Relation to Dehiscence Location and Size
Authors: Maheu Maxime , Elblidi Ahlem , Saliba Issam
Published: September 2021

Compare the sensitivity and specificity of cVEMP (500 Hz), oVEMP (500 Hz and 4 kHz) in the identification of SSCD. A secondary objective was to identify the influence of dehiscence size and location on cVEMP and oVEMP responses. Methods: Individuals with unilateral (n = 16) and bilateral (n = 10) scan confirmed SSCD were assessed using air-conducted cVEMP and oVEMP Results: For cVEMP, an amplitude cutoff of 286.9 μV or a threshold cutoff of 67.5 dBnHL revealed, respectively, a sensitivity of 75% and 70.6% and a specificity of 69.4% and 100%. For oVEMP (500 Hz), an amplitude cutoff of 10.8 μV or a threshold cutoff of 77.5 dBnHL revealed a sensitivity of 83.33% and a specificity of 87.5% and 80%, respectively. oVEMP (4 kHz), an amplitude cutoff of 3.1 μV, revealed a high specificity of 100% but a low sensitivity of 47.2%. A positive correlation was noted between the length of the SSCD and the cVEMP and oVEMP (500 Hz) thresholds and cVEMP amplitude. Conclusions: Our results support the use of oVEMP in the identification of SSCD. The presence of oVEMP (500 Hz) with an amplitude higher or equal to 10.8 μV, a threshold lower or equal to 77.5 dBnHL or oVEMP (4 kHz) amplitude of 3.1 μV represents the most useful to identify SSCD.
AI Based Emotion Detection for Textual Big Data: Techniques and Contribution
Authors: Kusal Sheetal , Patil Shruti , Kotecha Ketan , Aluvalu Rajanikanth , Varadarajan Vijayakumar
Published: September 2021

Online Social Media (OSM) like Facebook and Twitter has emerged as a powerful tool to express via text people’s opinions and feelings about the current surrounding events. Understanding the emotions at the fine-grained level of these expressed thoughts is important for system improvement. Such crucial insights cannot be completely obtained by doing AI-based big data sentiment analysis; hence, text-based emotion detection using AI in social media big data has become an upcoming area of Natural Language Processing research. It can be used in various fields such as understanding expressed emotions, human–computer interaction, data mining, online education, recommendation systems, and psychology. Even though the research work is ongoing in this domain, it still lacks a formal study that can give a qualitative (techniques used) and quantitative (contributions) literature overview. This study has considered 827 Scopus and 83 Web of Science research papers from the years 2005–2020 for the analysis. The qualitative review represents different emotion models, datasets, algorithms, and application domains of text-based emotion detection. The quantitative bibliometric review of contributions presents research details such as publications, volume, co-authorship networks, citation analysis, and demographic research distribution. In the end, challenges and probable solutions are showcased, which can provide future research directions in this area.
VAV Proteins as Double Agents in Cancer: Oncogenes with Tumor Suppressor Roles
Authors: Cuadrado Myriam , Robles-Valero Javier
Published: September 2021

Guanosine nucleotide exchange factors (GEFs) are responsible for catalyzing the transition of small GTPases from the inactive (GDP-bound) to the active (GTP-bound) states. RHO GEFs, including VAV proteins, play essential signaling roles in a wide variety of fundamental cellular processes and in human diseases. Although the most widespread archetype in the field is that RHO GEFs exert proactive functions in cancer, recent studies in mice and humans are providing new insights into the in vivo function of these proteins in cancer. These results suggest a more complex scenario where the role of GEFs is not so clearly defined. For example, VAV1 can unexpectedly play non-catalytic tumor suppressor functions in T-cell acute lymphoblastic leukemia (T-ALL) by controlling the levels of the active form of NOTCH1 (ICN1). This review focuses on emerging work unveiling tumor suppressor roles for these proteins that should prompt a reevaluation of the role of VAV GEF family in tumor biology.
HMGA1, Moonlighting Protein Function, and Cellular Real Estate: Location, Location, Location!
Authors: Pujals Mireia , Resar Linda , Villanueva Josep
Published: September 2021

The gene encoding the High Mobility Group A1 (HMGA1) chromatin remodeling protein is upregulated in diverse cancers where high levels portend adverse clinical outcomes. Until recently, HMGA1 was assumed to be a nuclear protein exerting its role in cancer by transcriptionally modulating gene expression and downstream signaling pathways. However, the discovery of an extracellular HMGA1-RAGE autocrine loop in invasive triple-negative breast cancer (TNBC) cell lines implicates HMGA1 as a “moonlighting protein” with different functions depending upon cellular location. Here, we review the role of HMGA1, not only as a chromatin regulator in cancer and stem cells, but also as a potential secreted factor that drives tumor progression. Prior work found that HMGA1 is secreted from TNBC cell lines where it signals through the receptor for advanced glycation end products (RAGE) to foster phenotypes involved in tumor invasion and metastatic progression. Studies in primary TNBC tumors also suggest that HMGA1 secretion associates with distant metastasis in TNBC. Given the therapeutic potential to target extracellular proteins, further work to confirm this role in other contexts is warranted. Indeed, crosstalk between nuclear and secreted HMGA1 could change our understanding of tumor development and reveal novel therapeutic opportunities relevant to diverse human cancers overexpressing HMGA1.
Mediterranean Diet Food Components as Possible Adjuvant Therapies to Counteract Breast and Prostate Cancer Progression to Bone Metastasis
Authors: Maroni Paola , Bendinelli Paola , Fulgenzi Alessandro , Ferraretto Anita
Published: September 2021

Bone metastasis is a serious and often lethal complication of particularly frequent carcinomas, such as breast and prostate cancers, which not only reduces survival but also worsens the patients’ quality of life. Therefore, it is important to find new and/or additional therapeutic possibilities that can counteract the colonization of bone tissue. High adherence to the Mediterranean diet (MD) is effective in the prevention of cancer and improves cancer patients’ health, thus, here, we considered its impact on bone metastasis. We highlighted some molecular events relevant for the development of a metastatic phenotype in cancer cells and the alterations of physiological bone remodeling, which occur during skeleton colonization. We then considered those natural compounds present in MD foods with a recognized role to inhibit or reverse the metastatic process both in in vivo and in vitro systems, and we reported the identified mechanisms of action. The knowledge of this bioactivity by the dietary components of the MD, together with its wide access to all people, could help not only to maintain healthy status but also to improve the quality of life of patients with bone metastases.
Cognitive Impairment in Adult Patients with 5q-Associated Spinal Muscular Atrophy
Authors: Kizina Kathrin , Akkaya Yakup , Jokisch Daniel , Stolte Benjamin , Totzeck Andreas , Munoz-Rosales Juan , Thimm Andreas , Bolz Saskia , Brakemeier Svenja , Pul Refik , Aslan Derya , Hackert Jana , Kleinschnitz Christoph , Hagenacker Tim
Published: September 2021

In previous studies, a below-average, average, or above-average intelligence quotient (IQ) in children with SMA was detected but, aside from a severe physical disability, the cognitive performance of adult SMA patients has not yet been evaluated. The intelligence test used in this study, the Wechsler Adult Intelligence Scale, fourth edition (WAIS-IV), was used to measure major intelligence components of adult SMA patients. The WAIS-IV determines four index scores representing verbal comprehension, perceptual reasoning, working memory, and processing speed. Due to time-dependent demands on motor function, the processing speed index score was excluded. IQ index scores of 33 adult SMA patients did not differ from IQ index scores of the normal population. In SMA type-3 patients, the index scores for verbal comprehension, perceptual reasoning, and working memory did not differ from the normal population but showed a trend of IQ scores towards lower points. Patients with SMA type 2 had lower IQ index scores for working memory (90.33 ± 12.95; p = 0.012) and perceptual reasoning (90.73 ± 12.58; p = 0.013) than the normal population. This study provided further evidence that SMA is a multi-systemic disease and may refute the widespread hypothesis that SMA patients might improve their cognitive skills to compensate for their physical impairment.
Surfaceome Profiling of Rhabdomyosarcoma Reveals B7-H3 as a Mediator of Immune Evasion
Authors: Lavoie Roxane R. , Gargollo Patricio C. , Ahmed Mohamed E. , Kim Yohan , Baer Emily , Phelps Doris A. , Charlesworth Cristine M. , Madden Benjamin J. , Wang Liguo , Houghton Peter J. , Cheville John , Dong Haidong , Granberg Candace F. , Lucien Fabrice
Published: September 2021

Novel therapeutic strategies are needed for the treatment of rhabdomyosarcoma (RMS), the most common soft-tissue sarcoma in children. By using a combination of cell surface proteomics and transcriptomic profiling of RMS and normal muscle, we generated a catalog of targetable cell surface proteins enriched in RMS tumors. Among the top candidates, we identified B7-H3 as the major immunoregulatory molecule expressed by RMS tumors. By using a large cohort of tissue specimens, we demonstrated that B7-H3 is expressed in a majority of RMS tumors while not detected in normal human tissues. Through a deconvolution analysis of the RMS tumor RNA-seq data, we showed that B7-H3-rich tumors are enriched in macrophages M1, NK cells, and depleted in CD8+-T cells. Furthermore, in vitro functional assays showed that B7-H3 knockout in RMS tumor cells increases T-cell mediated cytotoxicity. Altogether, our study uncovers new potential targets for the treatment of RMS and provides the first biological insights into the role of B7-H3 in RMS biology, paving the way for the development of next-generation immunotherapies.
Elderly Patients with Locally Advanced and Unresectable Non-Small-Cell Lung Cancer May Benefit from Sequential Chemoradiotherapy
Authors: Zaborowska-Szmit Magdalena , Olszyna-Serementa Marta , Kowalski Dariusz M. , Szmit Sebastian , Krzakowski Maciej
Published: September 2021

Concurrent chemoradiotherapy is recommended for locally advanced and unresectable non-small-cell lung cancer (NSCLC), but radiotherapy alone may be used in patients that are ineligible for combined-modality therapy due to poor performance status or comorbidities, which may concern elderly patients in particular. The best candidates for sequential chemoradiotherapy remain undefined. The purpose of the study was to determine the importance of a patients’ age during qualification for sequential chemoradiotherapy. The study enrolled 196 patients. Older patients (age > 65years) more often had above the median Charlson Comorbidity Index CCI > 4 (p < 0.01) and Simplified Charlson Comorbidity Index SCCI > 8 (p = 0.03), and less frequently the optimal Karnofsky Performance Score KPS = 100 (p < 0.01). There were no significant differences in histological diagnoses, frequency of stage IIIA/IIIB, weight loss, or severity of smoking between older and younger patients. Older patients experienced complete response more often (p = 0.01) and distant metastases less frequently (p = 0.03). Univariable analysis revealed as significant for overall survival: age > 65years (HR = 0.66; p = 0.02), stage IIIA (HR = 0.68; p = 0.01), weight loss > 10% (HR = 1.61; p = 0.04). Multivariable analysis confirmed age > 65years as a uniquely favorable prognostic factor (HR = 0.54; p < 0.01) independent of lung cancer disease characteristics, KPS = 100, CCI > 4, SCCI > 8. Sequential chemoradiotherapy may be considered as favorable in elderly populations.
Advances in the First Line Treatment of Pediatric Acute Myeloid Leukemia in the Polish Pediatric Leukemia and Lymphoma Study Group from 1983 to 2019
Authors: Czogała Małgorzata , Balwierz Walentyna , Pawińska-Wąsikowska Katarzyna , Książek Teofila , Bukowska-Strakova Karolina , Czogała Wojciech , Sikorska-Fic Barbara , Matysiak Michał , Skalska-Sadowska Jolanta , Wachowiak Jacek , Moj-Hackemer Małgorzata , Kałwak Krzysztof , Muszyńska-Rosłan Katarzyna , Krawczuk-Rybak Maryna , Grabowski Dominik , Kowalczyk Jerzy , Maciejka-Kembłowska Lucyna , Irga-Jaworska Ninela , Bobeff Katarzyna , Młynarski Wojciech , Tomaszewska Renata , Szczepański Tomasz , Chodała-Grzywacz Agnieszka , Karolczyk Grażyna , Mizia-Malarz Agnieszka , Mycko Katarzyna , Badowska Wanda , Zielezińska Karolina , Urasiński Tomasz , Urbańska-Rakus Justyna , Ciebiera Małgorzata , Chaber Radosław , Bartoszewicz Natalia , Wysocki Mariusz , Skoczeń Szymon
Published: September 2021

Background: From 1983, standardized therapeutic protocols for pediatric acute myeloid leukemia (AML) based on the BFM group experience were introduced in Poland. We retrospectively analyzed the results of pediatric AML treatment in Poland from 1983 to 2019 (excluding promyelocytic, therapy-related, biphenotypic, and Down syndrome AML). Methods: The study included 899 children suffering from AML treated with the following: AML-PPPLBC 83 (1983–1993, n = 187), AML-PPGLBC 94 (1994–1997, n = 74), AML-PPGLBC 98 (1998–2004, n = 151), AML-BFM 2004 Interim (2004–2015, n = 356), and AML-BFM 2012 (2015–2019, n = 131). Results: The probability of three-year overall survival was 0.34 ± 0.03, 0.37 ± 0.05, 0.54 ± 0.04, 0.67 ± 0.03, and 0.75 ± 0.05; event-free survival was 0.31 ± 0.03, 0.34 ± 0.05, 0.44 ± 0.04, 0.53 ± 0.03, and 0.67 ± 0.05; and relapse-free survival was 0.52 ± 0.03, 0.65 ± 0.05, 0.58 ± 0.04, 0.66 ± 0.03, and 0.78 ± 0.05, respectively, in the subsequent periods. A systematic reduction of early deaths and deaths in remission was achieved, while the percentage of relapses decreased only in the last therapeutic period. Surprisingly good results were obtained in the group of patients treated with AML-BFM 2012 with unfavorable genetic abnormalities like KMT2A-MLLT10/t(10;11)(p12;q23) and DEK-NUP214/t(6;9)(p23;q24), while unsatisfactory outcomes were found in the patients with FLT3-ITD. Conclusions: The use of standardized, systematically modified therapeutic protocols, with the successive consideration of genetic prognostic factors, and advances in supportive care led to a significant improvement in AML treatment outcomes over the last 40 years.
The Emerging Plasticizer Alternative DINCH and Its Metabolite MINCH Induce Oxidative Stress and Enhance Inflammatory Responses in Human THP-1 Macrophages
Authors: Schaffert Alexandra , Arnold Josi , Karkossa Isabel , Blüher Matthias , von Bergen Martin , Schubert Kristin
Published: September 2021

The use of the plasticizer bis(2-ethylhexyl)phthalate (DEHP) and other plasticizers in the manufacture of plastic products has been restricted due to adverse health outcomes such as obesity, metabolic syndrome, and asthma, for which inflammation has been described to be a driving factor. The emerging alternative plasticizer 1,2-cyclohexanedioic acid diisononyl ester (DINCH) still lacks information regarding its potential effects on the immune system. Here, we investigated the effects of DINCH and its naturally occurring metabolite monoisononylcyclohexane-1,2-dicarboxylic acid ester (MINCH) on the innate immune response. Human THP-1 macrophages were exposed to 10 nM–10 μM DINCH or MINCH for 4 h, 16 h, and 24 h. To decipher the underlying mechanism of action, we applied an untargeted proteomic approach that revealed xenobiotic-induced activation of immune-related pathways such as the nuclear factor κB (NF-κB) signaling pathway. Key drivers were associated with oxidative stress, mitochondrial dysfunction, DNA damage repair, apoptosis, and autophagy. We verified increased reactive oxygen species (ROS) leading to cellular damage, NF-κB activation, and subsequent TNF and IL-1β release, even at low nM concentrations. Taken together, DINCH and MINCH induced cellular stress and pro-inflammatory effects in macrophages, which may lead to adverse health effects.
Transcriptional Landscaping Identifies a Beige Adipocyte Depot in the Newborn Mouse
Authors: Hoang Anh Cuong , Yu Haidong , Röszer Tamás
Published: September 2021

The present study sought to identify gene networks that are hallmarks of the developing inguinal subcutaneous adipose tissue (iWAT) and the interscapular brown adipose tissue (BAT) in the mouse. RNA profiling revealed that the iWAT of postnatal (P) day 6 mice expressed thermogenic and lipid catabolism transcripts, along with the abundance of transcripts associated with the beige adipogenesis program. This was an unexpected finding, as thermogenic BAT was believed to be the only site of nonshivering thermogenesis in the young mouse. However, the transcriptional landscape of BAT in P6 mice suggests that it is still undergoing differentiation and maturation, and that the iWAT temporally adopts thermogenic and lipolytic potential. Moreover, P6 iWAT and adult (P56) BAT were similar in their expression of immune gene networks, but P6 iWAT was unique in the abundant expression of antimicrobial proteins and virus entry factors, including a possible receptor for SARS-CoV-2. In summary, postnatal iWAT development is associated with a metabolic shift from thermogenesis and lipolysis towards fat storage. However, transcripts of beige-inducing signal pathways including β-adrenergic receptors and interleukin-4 signaling were underrepresented in young iWAT, suggesting that the signals for thermogenic fat differentiation may be different in early postnatal life and in adulthood.
Time-Dependent Protective and Pro-Resolving Effects of FPR2 Agonists on Lipopolysaccharide-Exposed Microglia Cells Involve Inhibition of NF-κB and MAPKs Pathways
Authors: Tylek Kinga , Trojan Ewa , Leśkiewicz Monika , Regulska Magdalena , Bryniarska Natalia , Curzytek Katarzyna , Lacivita Enza , Leopoldo Marcello , Basta-Kaim Agnieszka
Published: September 2021

Prolonged or excessive microglial activation may lead to disturbances in the resolution of inflammation (RoI). The importance of specialized pro-resolving lipid mediators (SPMs) in RoI has been highlighted. Among them, lipoxins (LXA4) and aspirin-triggered lipoxin A4 (AT-LXA4) mediate beneficial responses through the activation of N-formyl peptide receptor-2 (FPR2). We aimed to shed more light on the time-dependent protective and anti-inflammatory impact of the endogenous SPMs, LXA4, and AT-LXA4, and of a new synthetic FPR2 agonist MR-39, in lipopolysaccharide (LPS)-exposed rat microglial cells. Our results showed that LXA4, AT-LXA4, and MR-39 exhibit a protective and pro-resolving potential in LPS-stimulated microglia, even if marked differences were apparent regarding the time dependency and efficacy of inhibiting particular biomarkers. The LXA4 action was found mainly after 3 h of LPS stimulation, and the AT-LXA4 effect was varied in time, while MR-39′s effect was mainly observed after 24 h of stimulation by endotoxin. MR-39 was the only FPR2 ligand that attenuated LPS-evoked changes in the mitochondrial membrane potential and diminished the ROS and NO release. Moreover, the LPS-induced alterations in the microglial phenotype were modulated by LXA4, AT-LXA4, and MR-39. The anti-inflammatory effect of MR-39 on the IL-1β release was mediated through FPR2. All tested ligands inhibited TNF-α production, while AT-LXA4 and MR-39 also diminished IL-6 levels in LPS-stimulated microglia. The favorable action of LXA4 and MR-39 was mediated through the inhibition of ERK1/2 phosphorylation. AT-LXA4 and MR39 diminished the phosphorylation of the transcription factor NF-κB, while AT-LXA4 also affected p38 kinase phosphorylation. Our results suggest that new pro-resolving synthetic mediators can represent an attractive treatment option for the enhancement of RoI, and that FPR2 can provide a perspective as a target in immune-related brain disorders.
The Landscape of IFN/ISG Signaling in HIV-1-Infected Macrophages and Its Possible Role in the HIV-1 Latency
Authors: Rojas Masyelly , Luz-Crawford Patricia , Soto-Rifo Ricardo , Reyes-Cerpa Sebastián , Toro-Ascuy Daniela
Published: September 2021

A key characteristic of Human immunodeficiency virus type 1 (HIV-1) infection is the generation of latent viral reservoirs, which have been associated with chronic immune activation and sustained inflammation. Macrophages play a protagonist role in this context since they are persistently infected while being a major effector of the innate immune response through the generation of type-I interferons (type I IFN) and IFN-stimulated genes (ISGs). The balance in the IFN signaling and the ISG induction is critical to promote a successful HIV-1 infection. Classically, the IFNs response is fine-tuned by opposing promotive and suppressive signals. In this context, it was described that HIV-1-infected macrophages can also synthesize some antiviral effector ISGs and, positive and negative regulators of the IFN/ISG signaling. Recently, epitranscriptomic regulatory mechanisms were described, being the N6-methylation (m6A) modification on mRNAs one of the most relevant. The epitranscriptomic regulation can affect not only IFN/ISG signaling, but also type I IFN expression, and viral fitness through modifications to HIV-1 RNA. Thus, the establishment of replication-competent latent HIV-1 infected macrophages may be due to non-classical mechanisms of type I IFN that modulate the activation of the IFN/ISG signaling network.
Effect of the Carrier on the Coprecipitation of Curcumin through Supercritical-Assisted Atomization
Authors: De Marco Iolanda , Franco Paola
Published: September 2021

In this paper, composite systems containing curcumin (CUR) were prepared through supercritical-assisted atomization (SAA), using different carriers. Curcumin is particularly interesting in the pharmaceutical and nutraceutical fields for its antioxidant, antitumoral, and anti-inflammatory properties. However, its therapeutic effect on human health is restricted by its poor water solubility and low dissolution rate, limiting its absorption after its oral administration. To increase the dissolution rate and then the bioavailability of the active compound, CUR was coprecipitated with polymeric, i.e., polyvinylpyrrolidone (PVP) and dextran (DXT), and not polymeric, i.e., hydroxypropyl-β-cyclodextrin (HP-β-CD), carriers. The effects of some operating parameters, namely the concentration of solutes in solution and the active compound/carrier ratio, on the morphology and the particle size distribution of the powders were investigated. Submicrometric particles were produced with all the carriers. Under the best operating conditions, the mean diameters ± standard deviation were equal to 0.69 ± 0.20 μm, 0.40 ± 0.13 μm, and 0.81 ± 0.25 μm for PVP/CUR, DXT/CUR, and HP-β-CD/CUR, respectively. CUR dissolution rates from coprecipitated particles were significantly increased in the case of all the carriers. Therefore, the results are exciting from a pharmaceutical and nutraceutical point of view, to produce supplements containing curcumin, but assuring a high dissolution rate and bioavailability and, consequently, a more effective therapeutic effect.
Saussurea lappa Exhibits Anti-Oncogenic Effect in Hepatocellular Carcinoma, HepG2 Cancer Cell Line by Bcl-2 Mediated Apoptotic Pathway and Mitochondrial Cytochrome C Release
Authors: Alotaibi Amal A. , Bepari Asmatanzeem , Assiri Rasha Assad , Niazi Shaik Kalimulla , Nayaka Sreenivasa , Rudrappa Muthuraj , Nagaraja Shashiraj Kareyellapa , Bhat Meghashyama Prabhakara
Published: September 2021

Background and Objectives: Saussurea lappa (S. lappa) is an important species of the Asteraceae family with several purposes in traditional medicine. This study intended to explore the cytotoxic effect of S. lappa on HepG2 cancer cell proliferation. Materials and Methods: The effects of an S. lappa n-butanol extract on the induction of apoptosis were investigated by flow cytometry and mitochondrial cytochrome C-releasing apoptosis assay. Additionally, real-time PCR was employed to confirm apoptosis initiation. Further, qualitative estimation of the active constituent of S. lappa was done by gas chromatography–mass spectroscopy (GC–MS). Results: The cell viability study revealed that the n-butanol extract of S. lappa demonstrated potent cytotoxicity against HepG2 cancer cells, with an IC50 value of 56.76 μg/mL. Cell morphology with dual staining of acridine orange (AO)-ethidium bromide (EB) showed an increase in orange/red nuclei due to cell death by S. lappa n-butanol extract compared to control cells. Apoptosis, as the mode of cell death, was also confirmed by the higher release of cytochrome C from mitochondria, the increased expression of caspase-3 and bax, along with down regulation of Bcl-2. Conclusion: These findings conclude that S. lappa is a cause of hepatic cancer cell death through apoptosis and a potential natural source suggesting furthermore investigation of its active compounds that are responsible for these observed activities.
Time-Domain Analysis of Tamper Displacement during Dynamic Compaction Based on Automatic Control
Authors: Li Xi , Yang Hui , Zhang Jingyu , Qian Guoping , Yu Huanan , Cai Jun
Published: September 2021

Crater depth is a vital issue in dynamic compaction (DC) because it is a controlling parameter in DC and a characterization index of soil properties. A continuous mathematical model capturing the time-domain process of tamper displacement is presented in this paper. The model is simple and the parameters involved are easy to obtain. It was found that the accumulated crater depth increases but its increment in the crater depth decreases with multiple impacts. Three groups of large-scale DC tests with 10,000 kN∙m were conducted to evaluate the performance of the proposed model. The results showed that the proposed model captures the typical trends in the tamper displacement of single and multiple impacts. In addition, a concept of the crater depth ratio is proposed based on the proposed model, and the concept is used to evaluate the efficiency of DC and to predict the optimum tamping number of DCs.
Visible Light Communication System Technology Review: Devices, Architectures, and Applications
Authors: Yu Tai-Cheng , Huang Wei-Ta , Lee Wei-Bin , Chow Chi-Wai , Chang Shu-Wei , Kuo Hao-Chung
Published: September 2021

Visible light communication (VLC) is an advanced, highly developed optical wireless communication (OWC) technology that can simultaneously provide lighting and high-speed wireless data transmission. A VLC system has several key advantages: ultra-high data rate, secure communication channels, and a lack of interference from electromagnetic (EM) waves, which enable a wide range of applications. Light-emitting diodes (LEDs) have been considered the optimal choice for VLC systems since they can provide excellent illumination performance. However, the quantum confinement Stark effect (QCSE), crystal orientation, carrier lifetime, and recombination factor will influence the modulation bandwidth, and the transmission performance is severely limited. To solve the insufficient modulation bandwidth, micro-LEDs (μ-LEDs) and laser diodes (LDs) are considered as new ideal light sources. Additionally, the development of modulation technology has dramatically increased the transmission capacity of the system. The performance of the VLC system is briefly discussed in this review article, as well as some of its prospective applications in the realms of the industrial Internet of Things (IoT), vehicle communications, and underwater wireless network applications.
Association between Intraoperative Hyperlactatemia and Myocardial Injury after Noncardiac Surgery
Authors: Kim Jeayoun , Park Jungchan , Kwon Ji-Hye , Kim Sojin , Oh Ah Ran , Jang Jae Ni , Choi Jin-Ho , Sung Jidong , Yang Kwangmo , Kim Kyunga , Ahn Joonghyun , Lee Seung-Hwa
Published: September 2021

Background: Oxygen demand–supply mismatch is supposed to be one of the major causes of myocardial injuries after noncardiac surgery (MINS). Impaired tissue oxygenation during the surgery can lead to intraoperative hyperlactatemia. Therefore, we aimed to evaluate the relationship between intraoperative lactate level and MINS. Methods: A total of 1905 patients divided into groups according to intraoperative hyperlactatemia: 1444 patients (75.8%) into normal (≤2.2 mmol/L) and 461 patients (24.2%) into hyperlactatemia (>2.2 mmol/L) groups. The primary outcome was the incidence of MINS, and all-cause mortality within 30 days was compared. Results: In the crude population, the risks for MINS and 30-day mortality were higher for the hyperlactatemia group than the normal group (17.7% vs. 37.7%, odds ratio [OR]: 2.83, 95% confidence interval [CI]: 2.24–3.56, p < 0.001 and 0.8% vs. 4.8%, hazard ratio [HR]: 5.86, 95% CI: 2.9–12.84, p < 0.001, respectively). In 365 propensity score-matched pairs, intraoperative hyperlactatemia was consistently associated with MINS and 30-day mortality (21.6% vs. 31.8%, OR: 1.69, 95% CI: 1.21–1.36, p = 0.002 and 1.1% vs. 3.8%, HR: 3.55, 95% CI: 1.71–10.79, p < 0.03, respectively). Conclusion: Intraoperative lactate elevation was associated with a higher incidence of MINS and 30-day mortality.
On the Entropy of a One-Dimensional Gas with and without Mixing Using Sinai Billiard
Authors: Sobol Alexander , Güntert Peter , Riek Roland
Published: September 2021

A one-dimensional gas comprising N point particles undergoing elastic collisions within a finite space described by a Sinai billiard generating identical dynamical trajectories are calculated and analyzed with regard to strict extensivity of the entropy definitions of Boltzmann–Gibbs. Due to the collisions, trajectories of gas particles are strongly correlated and exhibit both chaotic and periodic properties. Probability distributions for the position of each particle in the one-dimensional gas can be obtained analytically, elucidating that the entropy in this special case is extensive at any given number N. Furthermore, the entropy obtained can be interpreted as a measure of the extent of interactions between molecules. The results obtained for the non-mixable one-dimensional system are generalized to mixable one- and two-dimensional systems, the latter by a simple example only providing similar findings.
An Electric Fish-Based Arithmetic Optimization Algorithm for Feature Selection
Authors: Ibrahim Rehab Ali , Abualigah Laith , Ewees Ahmed A. , Al-qaness Mohammed A. A. , Yousri Dalia , Alshathri Samah , Abd Elaziz Mohamed
Published: September 2021

With the widespread use of intelligent information systems, a massive amount of data with lots of irrelevant, noisy, and redundant features are collected; moreover, many features should be handled. Therefore, introducing an efficient feature selection (FS) approach becomes a challenging aim. In the recent decade, various artificial methods and swarm models inspired by biological and social systems have been proposed to solve different problems, including FS. Thus, in this paper, an innovative approach is proposed based on a hybrid integration between two intelligent algorithms, Electric fish optimization (EFO) and the arithmetic optimization algorithm (AOA), to boost the exploration stage of EFO to process the high dimensional FS problems with a remarkable convergence speed. The proposed EFOAOA is examined with eighteen datasets for different real-life applications. The EFOAOA results are compared with a set of recent state-of-the-art optimizers using a set of statistical metrics and the Friedman test. The comparisons show the positive impact of integrating the AOA operator in the EFO, as the proposed EFOAOA can identify the most important features with high accuracy and efficiency. Compared to the other FS methods whereas, it got the lowest features number and the highest accuracy in 50% and 67% of the datasets, respectively.
A Data-Driven Space-Time-Parameter Reduced-Order Model with Manifold Learning for Coupled Problems: Application to Deformable Capsules Flowing in Microchannels
Authors: Boubehziz Toufik , Quesada-Granja Carlos , Dupont Claire , Villon Pierre , De Vuyst Florian , Salsac Anne-Virginie
Published: September 2021

An innovative data-driven model-order reduction technique is proposed to model dilute micrometric or nanometric suspensions of microcapsules, i.e., microdrops protected in a thin hyperelastic membrane, which are used in Healthcare as innovative drug vehicles. We consider a microcapsule flowing in a similar-size microfluidic channel and vary systematically the governing parameter, namely the capillary number, ratio of the viscous to elastic forces, and the confinement ratio, ratio of the capsule to tube size. The resulting space-time-parameter problem is solved using two global POD reduced bases, determined in the offline stage for the space and parameter variables, respectively. A suitable low-order spatial reduced basis is then computed in the online stage for any new parameter instance. The time evolution of the capsule dynamics is achieved by identifying the nonlinear low-order manifold of the reduced variables; for that, a point cloud of reduced data is computed and a diffuse approximation method is used. Numerical comparisons between the full-order fluid-structure interaction model and the reduced-order one confirm both accuracy and stability of the reduction technique over the whole admissible parameter domain. We believe that such an approach can be applied to a broad range of coupled problems especially involving quasistatic models of structural mechanics.
Spintronic RF-Direct on-off Keying Modulation Using a Frequency Division Multiplex
Authors: Oh Inn-Yeal , Kang Min-Soo , Kim Kun-Sik , Choi Chang-Ha
Published: September 2021

This paper presents the results of spintronic wireless communication using a new modulation method, spin RF-direct on-off keying modulation using a frequency division multiplex (FDM), which modulates amplitude and frequency simultaneously with a spin torque nano-oscillator (STNO) array. For the new modulation technique, each channel can be assigned to every STNO on the STNO array, and each STNO is simultaneously modulated by on-off keying with digital data directly. These modulation technologies have the advantage of increasing the data transmission rate by the number of operating STNOs. In recent years, efforts to increase the speed of transmission are important as the amount of data it sends increase. The receiver demodulates data on every channel through a band pass filter acquiring the frequency assigned to each channel, respectively. To initially confirm the possibility of realizing spin RF-direct on-off keying modulation using an FDM, we demonstrated the proposed modulation technique with two STNOs in an array, setting one STNO at 3.5 GHz frequency and the other at 4.2 GHz, and communicated wirelessly with a two-channel receiver in the near field. A data rate of up to 4 Mbps is obtained with the new modulation technique under 10 mm distance, and the DC power consumption is 0.18 mW per STNO in transmitter, including logic circuit operation.
An Effective Transmission Scheme Based on Early Congestion Detection for Information-Centric Network
Authors: Xu Yong , Ni Hong , Zhu Xiaoyong
Published: September 2021

As one of the candidates for future network architecture, Information-Centric Networking (ICN) has revolutionized the manner of content retrieval by transforming the communication mode from host-centric to information-centric. Unlike a traditional TCP/IP network, ICN uses a location-independent name to identify content and takes a receiver-driven model to retrieve the content. Moreover, ICN routers not only perform a forwarding function but also act as content providers due to pervasive in-network caching. The network traffic is more complicated and routers are more prone to congestion. These distinguished characteristics pose new challenges to ICN transmission control mechanism. In this paper, we propose an effective transmission scheme by combining the receiver-driven transport protocol and the router-driven congestion detection mechanism. We first outline the process of content retrieval and transmission in an IP-compatible ICN architecture and propose a practical receiver-driven transport protocol. Then, we present an early congestion detection mechanism applied on ICN routers based on an improved Active Queue Management (AQM) algorithm and design a receiver-driven congestion control algorithm. Finally, experiment results show that the proposed transmission scheme can maintain high bandwidth utilization and significantly reduce transmission delay and packet loss rate.
Methods of Determining Pressure Drop in Internal Channels of a Hydraulic Motor
Authors: Sliwinski Pawel , Patrosz Piotr
Published: September 2021

In this paper, new methods for determining the pressure drop in internal channels of a hydraulic motor are proposed and described. Mathematical models of pressure losses in internal channels have also been described. Experimental tests of the satellite motor were carried out according to one of the proposed methods. The tests were carried out for two liquids, i.e., water and mineral oil. Experimental studies have shown that at a high flow rate in the motor supplied with water the pressure losses are a dozen or so percent greater than in the motor supplied with oil. However, at low flow rates is the inverse, that is, the pressure losses in the motor supplied with water are about ten percent lower than in the motor supplied with oil. The CFD calculation of the pressure drop in the internal channel of the motor was also conducted. It was assumed that holes in the commutation unit plate are placed face to face and that the liquid did not cause changes in the working chambers’ volume. In this way, it has been proven that those simplified assumptions can have up to a 50% difference in relation to the experimental tests.
Evaluation of Electrical Performance and Life Estimation of PPs for HVDC Power Cable
Authors: Lee Seung-Won , Kim Hae-Jong , Kwon Ik-Su , Lim Jang-Seob
Published: September 2021

Demand and need for the application of high voltage direct current (HVDC) are increasing because of high capacity and long-distance transmission. Research on polypropylene (PP) that can increase the operation temperature compared to existing insulation is constantly being considered. This study aimed to evaluate the electrical performance and estimate the life of HVDC application of PP. In this study, a DC V-t characteristic tests were conducted on three types of PP sheets at a temperature of 110 °C. In addition, a life estimation formula based on the electrical stress was derived and the electrical performances were evaluated. The experimental results show that the life exponent of material mixed with block copolymer, homo polymer and high density polyethylene (HDPE) was 23 and the electrical performance was 17% better than block copolymer, thereby demonstrating the reliability and electrical performance for application of HVDC.
Influence of Arc Size on the Ignition and Flame Propagation of Cable Fire
Authors: Li Chenying , Chen Jie , Zhang Wei , Hu Libing , Cao Jingying , Liu Jianjun , Zhu Zhenyu , Wu Shuqun
Published: September 2021

Cable fire caused by arc faults is one of the essential factors threatening the safe operation of a power system. The ignition and flame propagation of cable fire dependent on the characteristics of the arc discharge is lackingin in-depth understanding at present. In this work, with the constant electric power deposited into the arc discharge, the effects of arc size on the ignition and flame propagation of 110 kV XLPE cable fire are investigated for the first time. The arc size is changed by varying the gap distance of electrodes from 1.5 cm to 2.5 cm. It is interesting to find that the larger the arc size is, the faster the cable fire is ignited and propagates, and the larger the damaged area of the sheath of the cable is. Therein, when the gap distance increases from 1.3 cm to 3.1 cm, the equivalent impedance and the length of the arc discharge increase nearly seven times and three times, respectively. However, the gas temperature of the arc decreases slightly from 2280 K to 2100 K. In addition, a 3D model of the cable fire ignited by arc discharge is computed by Pyrosim software with fire dynamic simulation (FDS) module. Simulated results show that as the arc size increases, the cable fire is ignited faster, the flame propagates both vertically and horizontally increasing significantly, which is agreed well with the experimental results. This study deepens the understanding of the cable fire ignited by arc discharge and therefore it is useful for the evaluation and prevention of cable fire.
A Review of Key Performance Indicators for Building Flexibility Quantification to Support the Clean Energy Transition
Authors: Airò Farulla Girolama , Tumminia Giovanni , Sergi Francesco , Aloisio Davide , Cellura Maurizio , Antonucci Vincenzo , Ferraro Marco
Published: September 2021

The transition to a sustainable society and a carbon-neutral economy by 2050 requires extensive deployment of renewable energy sources that, due to the aleatority and non-programmability of most of them, may seriously affect the stability of existing power grids. In this context, buildings are increasingly being seen as a potential source of energy flexibility for the power grid. In literature, key performance indicators, allowing different aspects of the load management, are used to investigate buildings’ energy flexibility. The paper reviews existing indicators developed in the context of theoretical, experimental and numerical studies on flexible buildings, outlining the current status and the potential future perspective. Moreover, the paper briefly reviews the range of grid services that flexible buildings can provide to support the reliability of the electric power system which is potentially challenged by the increasing interconnection of distributed variable renewable generation.
Impact of Remediation-Based Maintenance on the Reliability of a Coal-Fired Power Plant Using Generalized Stochastic Petri Nets
Authors: Batelić Jakov , Griparić Karlo , Matika Dario
Published: September 2021

Rapid changes in electricity power markets have increased the production costs of coal-fired power plants and pushed their production to the limits of profitability. For power plants currently in operation, a possible approach to cope with this issue is to introduce novel methods that increase the plant’s reliability and availability. Coal mills are a subsystem that should ensure a plant’s availability without unexpected breakdowns. Remediation-based maintenance is defined as a set of actions performed after fault detection that do not require instant shutdown due to safety reasons. The aim of this paper was to provide a scientific confirmation that by implementing a novel remediation-based maintenance strategy, electricity production breakdowns can be significantly reduced. First, the performance of the proposed maintenance method was proved in simulation where coal mills were modeled by generalized stochastic Petri nets. The maintenance strategy was then experimentally verified in a 220 MW coal-fired power plant located in Croatia, where the plant’s availability, reliability and efficiency were increased.