bluuebunny/crossref_metadata_2025 huggingface dataset:
Risk Adjustment for Lumbar Dysfunction: Comparison of Linear Mixed Models With and Without Inclusion of Between-Clinic Variation as a Random Effect
Authors: Yen Sheng-Che , Corkery Marie B. , Chui Kevin K. , Manjourides Justin , Wang Ying-Chih , Resnik Linda J.
Published: April 2015

Background

Valid comparison of patient outcomes of physical therapy care requires risk adjustment for patient characteristics using statistical models. Because patients are clustered within clinics, results of risk adjustment models are likely to be biased by random, unobserved between-clinic differences. Such bias could lead to inaccurate prediction and interpretation of outcomes.

Purpose

The purpose of this study was to determine if including between-clinic variation as a random effect would improve the performance of a risk adjustment model for patient outcomes following physical therapy for low back dysfunction.

Design

This was a secondary analysis of data from a longitudinal cohort of 147,623 patients with lumbar dysfunction receiving physical therapy in 1,470 clinics in 48 states of the United States.

Methods

Three linear mixed models predicting patients' functional status (FS) at discharge, controlling for FS at intake, age, sex, number of comorbidities, surgical history, and health care payer, were developed. Models were: (1) a fixed-effect model, (2) a random-intercept model that allowed clinics to have different intercepts, and (3) a random-slope model that allowed different intercepts and slopes for each clinic. Goodness of fit, residual error, and coefficient estimates were compared across the models.

Results

The random-effect model fit the data better and explained an additional 11% to 12% of the between-patient differences compared with the fixed-effect model. Effects of payer, acuity, and number of comorbidities were confounded by random clinic effects.

Limitations

Models may not have included some variables associated with FS at discharge. The clinics studied may not be representative of all US physical therapy clinics.

Conclusions

Risk adjustment models for functional outcome of patients with lumbar dysfunction that control for between-clinic variation performed better than a model that does not.
Experimental investigation of thermal mixing phenomena in a tee pipe
Authors: Chen Mei-Shiue , Hsieh Huai-En , Zhang Zhi-Yu , Pei Bau-Shi
Published: April 2015

T-pipe designs have been widely used in the industry. Among them, mixing of hot and cold water is a common application. In the mixing process, cold and hot fluids are respectively injected through main and branch pipes, and are mixed in the downstream area of T-tube. High temperature hot water flows through the main pipe for a long time; hence, the pipe wall is at high temperatures. The fluid injected into the branch pipe is a cooling fluid. After mixing, the wall of the main pipe is under high thermal fluctuations causing strong thermal stresses, which will eventually lead to pipe damage and water loss. Through flow rate adjustments of the branch and main pipes, when the branch/main velocity ratio was greater than 7.8, showing that cold water hit the bottom of the main pipe and created a reverse flow. This reverse flow created large thermal stresses on the wall. Hence, the branch/main velocity ratio and the hot-water-mixing phenomenon are the focus of this study.
An analytical approach for a nodal formulation of a two-dimensional fixed-source neutron transport problem in heterogeneous medium
Authors: Barichello L. B. , da Cunha R. D. , Picoloto C. B. , Tres A.
Published: April 2015

A nodal formulation of a fixed-source two-dimensional neutron transport problem, in Cartesian geometry, defined in a heterogeneous medium, is solved by an analytical approach. Explicit expressions, in terms of the spatial variables, are derived for averaged fluxes in each region in which the domain is subdivided. The procedure is an extension of an analytical discrete ordinates method, the ADO method, for the solution of the two-dimensional homogeneous medium case. The scheme is developed from the discrete ordinates version of the two-dimensional transport equation along with the level symmetric quadrature scheme. As usual for nodal schemes, relations between the averaged fluxes and the unknown angular fluxes at the contours are introduced as auxiliary equations. Numerical results are in agreement with results available in the literature.
Flow impinging effect of critical heat flux and nucleation boiling heat transfer on a downward facing heating surface
Authors: Hsieh Huai-En , Chen Mei-Shiue , Chen Jyun-Wei , Lin Wei-Keng , Pei Bau-Shei
Published: April 2015

Boiling heat transfer has a high heat removal capability in convective cooling. However, the heat removal capability of downward-facing boiling is significantly worse than that of upward-facing cases because of the confined buoyancy effect. This study was inspired by the conception of external reactor vessel cooling (ERVC) condition relevant to the in-vessel retention (IVR) design of Westinghouse AP1000 plant. In the present study, a small-scale test facility had been established to investigate the local phenomena of boiling heat transfer under a downward-facing horizontal heated surface with impinging coolant flow. In this study, the surface temperature, heat flux information and several specific scenes of bubbles are taken down throughout the boiling processes for detailed investigation. It is observed that bubbles are confined under the downward-facing heated surface, which causes a worse heat transfer rate and a lower critical heat flux (CHF) limit than upward-facing boiling. Nevertheless, the impinging coolant flow is found to disturb the thermal boundary layer formed by the heated surface, so the CHF increases with an increase of coolant flow rate. In addition, during nucleate boiling, it is discovered that the growth, combination and dissipation of bubbles induce turbulent wakes and therefore enhance the heat transfer capability.
Operating experience feedback from safety significant events at research reactors
Authors: Shokr A. M. , Rao D.
Published: April 2015

Operating experience feedback is an effective mechanism to provide lessons learned from the events and the associated corrective actions to prevent recurrence of events, resulting in improving safety in the nuclear installations. This paper analyzes the events of safety significance that have been occurred at research reactors and discusses the root causes and lessons learned from these events. Insights from literature on events at research reactors and feedback from events at nuclear power plants that are relevant to research reactors are also presented along with discussions. The results of the analysis showed the importance of communication of safety information and exchange of operating experience are vital to prevent reoccurrences of events. The analysis showed also the need for continued attention to human factors and training of operating personnel, and the need for establishing systematic ageing management programmes of reactor facilities, and programmes for safety management of handling of nuclear fuel, core components, and experimental devices.
Benchmarks for a truly universal Post-2015 Agenda for Sustainable Development
Authors: Martens Jens
Published: April 2015

“Post-2015” is the “flavor of the day”; it is currently right in the center of the development discourse. The United Nations, governments, civil society organizations, researchers, and even business people are currently discussing what will come aft er the Millennium Development Goals (MDGs). As you all know, the reference period for the MDGs will expire in 2015, and this is the reason why the world community is now engaged in the task of formulating an agenda for the following period. But this Post-2015 Agenda can and must be much more than just an updated list of MDGs.
Nonmelanoma cutaneous cancers involving the skull base: outcomes of aggressive multimodal management
Authors: Raza Shaan M. , Ramakrishna Rohan , Weber Randal S. , Kupferman Michael E. , Gidley Paul W. , Hanna Ehab Y. , DeMonte Franco
Published: April 2015

OBJECT

A relative paucity of information exists regarding outcomes from craniofacial resection for advanced nonmelanoma skin cancers involving the skull base. In light of advances in surgical technique and adjuvant therapy protocols, the authors reviewed their surgical experience to determine disease control rates, overall survival (OS), morbidity, and mortality.

METHODS

A retrospective review of 24 patients with nonmelanoma cutaneous cancers with skull base involvement treated with craniofacial resection at The University of Texas MD Anderson Cancer Center from 1994 to 2012 was performed. Of these patients, 19 (79%) had squamous cell carcinoma (SCC), 4 (17%) had basosquamous carcinoma (BSCC), and 1 patient (4%) had adenocarcinoma. Factors as assessed were prior treatment, TNM staging, tumor involvement, extent of intracranial extension, margin status, postoperative complications, recurrence, disease status at last follow-up, and long-term survival. The majority of tumors were T4 (67%) according to the TNM classification; perineural extension was noted in 58%, cavernous sinus involvement in 25%, and dural involvement in 29%.

RESULTS

Postoperative complications occurred in 4 patients (17%) including 1 death. Kaplan-Meier estimates were calculated for OS and progression-free survival (PFS). Median OS was 43.2 months with an 82% 1-year OS and 37% 5-year OS; the median PFS was 91.2 months. Margin status was positively associated with median OS in SCC (91 months [for negative margins] vs 57 months, p = 0.8) and in BSCC (23.7 vs 3.2 months, p < 0.05). Postoperative radiotherapy was associated with improved median OS (43.2 vs 22 months, p = 0.6). Brain involvement was uniformly fatal after 1 year, while cavernous sinus involvement (31 vs 43 months, p = 0.82), perineural disease (31 vs 54 months, p = 0.30), and T4 stage (22 vs 91.2 months, p = 0.09) were associated with worsened OS. Similar associations were found with median PFS.

CONCLUSIONS

Aggressive multimodality management with surgery and postoperative radiotherapy can positively impact locoregional control and OS. With improvements in technique and adjuvant therapy protocols, treatment can still be considered in situations of perineural disease and cavernous sinus involvement and as a salvage option for patients in whom prior treatment has failed. As patients with advanced NMSCs often have few options, craniofacial resection, as part of a coordinated multimodal management plan, is justified if it can be performed safely.
Enhancing subdural effusions mimicking acute subdural hematomas following angiography and endovascular procedures: report of 2 cases
Authors: Zamora Carlos A. , Lin Doris D.
Published: April 2015

Hyperdense enhancing subdural effusion due to contrast extravasation has been recently described as a potential mimicker of acute subdural hematoma following a percutaneous coronary procedure. Herein, the authors report on 2 patients who presented with subarachnoid hemorrhage from ruptured cerebral aneurysms and who developed enhancing subdural effusions mimicking acute subdural hematomas after angiography and endovascular coil placement. In 1 case, the subdural effusions completely cleared but recurred after a second angiography. CT attenuation values higher than expected for blood, as well as the evolution of the effusions and density over time, allowed for differentiation of enhancing subdural effusions from acute subdural hematomas.
A quantitative analysis of adverse radiation effects following Gamma Knife radiosurgery for arteriovenous malformations
Authors: Cohen-Inbar Or , Lee Cheng-Chia , Xu Zhiyuan , Schlesinger David , Sheehan Jason P.
Published: April 2015

OBJECT

The authors review outcomes following Gamma Knife radiosurgery (GKRS) of cerebral arteriovenous malformations (AVMs) and their correlation to postradiosurgery adverse radiation effects (AREs).

METHODS

From a prospective institutional review board–approved database, the authors identified patients with a minimum of 2 years of follow-up and thin-slice T2-weighted MRI sequences for volumetric analysis. A total of 105 AVM patients were included. The authors analyzed the incidence and quantitative changes in AREs as a function of time after GKRS. Statistical analysis was performed to identify factors related to ARE development and changes in the ARE index.

RESULTS

The median clinical follow-up was 53.8 months (range 24–212.4 months), and the median MRI follow-up was 36.8 months (range 24–212.4 months). 47.6% of patients had an AVM with a Spetzler-Martin grade ≥ III. The median administered margin and maximum doses were 22 and 40 Gy, respectively. The overall obliteration rate was 70.5%. Of patients who showed complete obliteration, 74.4% developed AREs within 4–6 months after GKRS. Late-onset AREs (i.e., > 12 months) correlated to a failure to obliterate the nidus. 58.1% of patients who developed appreciable AREs (defined as ARE index > 8) proceeded to have a complete nidus obliteration. Appreciable AREs were found to be influenced by AVM nidus volume > 3 ml, lobar location, number of draining veins and feeding arteries, prior embolization, and higher margin dose. On the other hand, a minimum ARE index > 8 predicted obliteration (p = 0.043).

CONCLUSIONS

ARE development after radiosurgery follows a temporal pattern peaking at 7–12 months after stereotactic radiosurgery. The ARE index serves as an important adjunct tool in patient follow-up and outcome prediction.
Sagittal balance of the cervical spine: an analysis of occipitocervical and spinopelvic interdependence, with C-7 slope as a marker of cervical and spinopelvic alignment
Authors: Núñez-Pereira Susan , Hitzl Wolfgang , Bullmann Viola , Meier Oliver , Koller Heiko
Published: April 2015

OBJECT

Sagittal malalignment of the cervical spine has been associated with worsened postsurgical outcomes. For better operative planning of fusion and alignment restoration, improved knowledge of ideal fusion angles and interdependences between upper and lower cervical spine alignment is needed. Because spinal and spinopelvic parameters might play a role in cervical sagittal alignment, their associations should be studied in depth.

METHODS

The authors retrospectively analyzed digital lateral standing cervical radiographs of 145 patients (34 asymptomatic, 74 symptomatic; 37 surgically treated), including full-standing radiographs obtained in 45 of these patients. Sagittal measurements were as follows: C2–7, occiput (Oc)–C2, C1–2 Cobb angles, and C-7 slope (the angle between the horizontal line and the superior endplate of C-7), as well as T4–12 and L1–S1 Cobb angles, sacral slope, pelvic incidence, and C-7 sagittal vertical axis (SVA). A correlation analysis was performed, and linear regression models were developed.

RESULTS

Statistical analyses revealed significant correlations between C2–7 and Oc–C2 (r = −0.4, p < 0.01), Oc–C2 (r = −0.3, p < 0.01), and C1–2 angle (r = −0.3, p < 0.01). C-7 slope was significantly correlated with C2–7 (r = −0.5, p < 0.01) and with Oc–C2 angle (r = 0.2, p = 0.02). Total cervical (Oc–C7) lordosis was 30.2° and did not differ significantly among asymptomatic, symptomatic, and surgically treated patients. Correlations between C2–7 and Oc–C2 alignment were stronger in asymptomatic patients (r = –0.5, p < 0.01) and surgically treated patients (r = –0.5, p < 0.01) than in symptomatic patients (r = –0.3, p = 0.01), but the between-group difference was not significant (p > 0.1). Comparing cervical and spinopelvic alignment revealed a significant correlation between sacral slope and C-7 slope (r = –0.3, p = 0.04) and C2–7 (r = 0.4, p < 0.01). The C-7 SVA correlated significantly with the C-7 slope (r = –0.4, p < 0.01). The interdependences were stronger within the occipitocervical parameters than between the cervical and remaining spinal parameters.

CONCLUSIONS

Significant correlations between the upper and lower cervical spine exist, confirming the existence of inherent compensatory mechanisms to maintain overall balance; no significant differences were found among asymptomatic, symptomatic, and surgically treated patients. The C-7 slope is a useful marker of overall sagittal alignment, acting as a link between the occipitocervical and thoracolumbar spine.
A single-stage posterior approach with open reduction and pedicle screw fixation in subaxial cervical facet dislocations
Authors: Park Jin Hoon , Roh Sung Woo , Rhim Seung Chul
Published: April 2015

OBJECT

The optimal treatment for cervical facet dislocations is controversial, but the generally accepted process recommends an initial closed reduction with the next step determined according to the success of the closed reduction and the presence of traumatic disc herniation. This study aimed to show the efficacy of a posterior approach performed with an open reduction and pedicle screw fixation with removal of disc particles, if required, in the management of subaxial cervical dislocations.

METHODS

Between March 2012 and September 2013, 21 consecutive patients with cervical facet dislocations were enrolled. The affected levels were as follows: 4 at C3–4; 2 at C4–5; 5 at C5–6; and 10 at the C6–7 level. Seven patients had traumatic disc herniations. Closed reduction was not attempted; a prompt posterior cervical surgery was performed instead. After open reduction, pedicle screw fixation was performed. In cases with traumatic disc herniation, herniated disc fragments were excised via a posterolateral approach and successful decompressions were determined by postoperative MRI studies. Clinical outcomes were assessed using the American Spinal Injury Association (ASIA) grading system. Radiological outcomes were assessed by comparing the degree of subluxation and the angle of segmental lordosis between pre- and postoperative CT scans.

RESULTS

All patients improved neurologically. The mean segmental angles improved from 7.3° ± 8.68° to −5.9° ± 4.85°. The mean subluxation improved from 23.4% ± 16.52% to 2.6% ± 7.19%. Disc fragments were successfully removed from the 7 patients with herniated discs, as shown on MRI.

CONCLUSIONS

Open reduction followed by pedicle screw fixation or posterolateral removal of herniated disc fragments is a good treatment option for cervical facet dislocations.
Frontobiparietal remodeling with or without a widening bridge for sagittal synostosis: comparison of 2 cohorts for aesthetic and functional outcome
Authors: van Veelen Marie-Lise C. , Mihajlović Dalibor , Dammers Ruben , Lingsma Hester , van Adrichem Leon N. A. , Mathijssen Irene M. J.
Published: April 2015

OBJECT

Various techniques to correct sagittal synostosis have been described. The authors of this study assess the results of 2 techniques for late complete cranial remodeling and test the hypothesis that adding a widening bridge would improve outcome.

METHODS

In this retrospective study, the authors evaluated patients with nonsyndromic sagittal synostosis—those who underwent frontobiparietal remodeling (FBR) and those who underwent modified FBR (MFBR) involving the introduction of a bony bridge to increase the width of the skull. Outcomes for both groups are described in terms of the aesthetic results assessed on photographs and any changes in the cranial index (CI) and head circumference over time, the presence of papilledema, and complaints of headache. The effect of the surgical technique on CI and head circumference over time was assessed using linear regression analysis, with adjustment for preoperative CI and head circumference.

RESULTS

Sixty-nine patients with isolated sagittal synostosis were included in this study: 35 underwent MFBR and 34 underwent the original technique of FBR. The mean follow-up period was 7 years. In the 1st year after surgery, mean CI improved by 9% in the FBR group and by 12% in the MFBR group. One year after surgery, CI in the MFBR group was on average 4.7% higher than that in the FBR group (p < 0.001). During follow-up, CI decreased in both groups; however, at all time points CI was significantly higher in the MFBR group than in the FBR group. The impact of surgical technique on CI was less important than the impact of preoperative CI (R2= 0.26 vs 0.54), and this applied at all time points during follow-up. Head circumference declined during follow-up in both groups. It was influenced by preoperative head circumference, but not by surgical technique. Aesthetic outcome, prevalence of headache (42%), and papilledema (7%) were comparable in both groups.

CONCLUSIONS

Adding a widening bridge to late complete remodeling significantly improved CI and helped to prevent CI from decreasing in the long term. This addition did not affect the head circumference growth curve. Despite a mean head circumference remaining at +1 SD, patients continued to develop papilledema postoperatively (7%).
Endoscopic monoportal removal of a choroid plexus papilloma in the posterior third ventricle in a child
Authors: Sufianov Albert A. , Gaibov Saidi S. K. , Sufianov Rinat A.
Published: April 2015

Currently, only a few reports describe the minimally invasive removal of choroid plexus papillomas (CPPs) and, to the best of the authors' knowledge, no reports detail the resection of such a papilloma through an endoscopic approach in infants. The authors here describe the endoscopic removal of a third ventricle CPP in a child. A 5-month-old male infant presented with progressive macrocephaly, vomiting, and convulsions. A lesion in the posterior third ventricle was detected on brain MRI. Because of the patient's very young age, neuroendoscopy was used as the least invasive technique. The tumor was completely resected through a monoportal neuroendoscopic approach. Histologically, the tumor was classified as a WHO Grade I CPP. After surgery, the patient's condition improved, with no complications during his recovery. Ten-month follow-up neuroimaging revealed no evidence of tumor recurrence or progressive hydrocephaly. In view of the successful neuroendoscopic excision of this posterior third ventricle CPP, the authors believe that this method seems promising in the treatment of young children with intraventricular lesions.
The Double Four-Component Ugi Reaction between Squaramic or Squaramide Acids with Alkyl Isocyanides, Amines and Aromatic Aldehydes
Authors: Mehrabi Hossein , Saleki Tahereh
Published: April 2015

Novel symmetrical squaramides have been synthesised through the double four-component Ugi reaction between squaramic or squaramide acids with alkyl isocyanides, amines and aromatic aldehydes in methanol under room temperature conditions without using additional reagents or catalysts.
Rapid and Efficient Synthesis of a New Series of 2-Aryl-5-Fluoro-6-(4-Phenylpiperazin-1-Yl)-1H-Benzimidazoles Using Microwave Heating
Authors: Menteşe Emre , Yılmaz Fatih , İslamoğlu Fatih , Kahveci Bahittin
Published: April 2015

A new series of 2-aryl-5-fluoro-6-(4-phenylpiperazin-1-yl)-1H-benzimidazoles was synthesised from the reaction of 4-fluoro-5-(4-phenylpiperazin-1-yl)benzene-1,2-diamine and iminoester hydrochlorides. 4-Fluoro-5-(4-phenylpiperazin-1-yl)benzene-1,2-diamine was prepared from the reduction of 5-fluoro-2-nitro-4-(4-phenylpiperazin-1-yl)aniline by using Pd/C (10%) catalyst and hydrazine hydrate under microwave irradiation. The structures of newly synthesised compounds were identified by 1H NMR, 13C NMR, mass spectroscopy and elemental analysis data.
Facile Synthesis and Fluorescent Properties of Coumarin-7 and its Isomer 4-(2-Benzimidazolyl)-7-(Diethylamino)Coumarin
Authors: Wang Xiaolong , Yang Fang , Xue Ziyan , Wang Xiaoqiang , Chen Chen
Published: April 2015

Coumarin-7 and its isomer 4-(2-benzimidazolyl)-7-(diethylamino)coumarin were synthesised using condensation of the corresponding formylcoumarin with o-phenylenediamine as the key step. Moreover, absorption and fluorescence emission spectra of these two coumarins were recorded.
Synthesis of 6-t Rifluoromethyl Derivatives of 2-Arylamino-4-(Pyridin-3-yl) Pyrimidines
Authors: Terentjeva S. , Muceniece D. , Lūsis V.
Published: April 2015

The 6-trifluoromethyl derivative of a well known tyrosine kinase inhibitor, nilotinib, as well as some novel 6-trifluoromethyl substituted 2-arylamino-4-(pyridin-3-yl) pyrimidines were synthesised.
Enantioselective Synthesis of New Dimeric Chromene Derivatives by a Ferrocene-Copper Catalyst System
Authors: Xu Di , Dai Li , Li Lan , Zhou Zhiming , Zhang Jun
Published: April 2015

Novel 2-iminochromene dimers were prepared in excellent yields (93–99%) and with high to excellent enantioselectivities (89–97% ee) by a simple and efficient method. The precursor 2-[(3-cyano-2H-chromen-2-ylidene)amino]acetates and both racemic and enantioselective 2-iminochromene dimers were disclosed and characterised for the first time.
Effectiveness of Organic Wastes as Fertilizers and Amendments in Salt-Affected Soils
Authors: Diacono Mariangela , Montemurro Francesco
Published: April 2015

Excessive salt rate can adversely influence the physical, chemical, and biological properties of soils, mainly in arid and semi-arid world regions. Therefore, salt-affected soils must be reclaimed to maintain satisfactory fertility levels for increasing food production. Different approaches have been suggested to solve these issues. This short review focuses on selected studies that have identified organic materials (e.g., farmyard manures, different agro-industrial by-products, and composts) as effective tools to improve different soil properties (e.g., structural stability and permeability) in salt-affected soils. Organic fertilization is highly sustainable when compared to other options to date when taken into consideration as a solution to the highlighted issues. However, further experimental investigations are needed to validate this approach in a wider range of both saline and sodic soils, also combining waste recycling with other sustainable agronomic practices (crop rotations, cover crops use, etc.).
Introduction and Editorial to the Special Issue “Selected Papers from the Building a Better New Zealand (BBNZ 2014) Conference”
Authors: Baird George
Published: April 2015

The current “Building a Better New Zealand” initiative began in 2009 with the New Zealand Government and the Building Industry working together to develop “Building the Future”—a document that looked at the challenges and opportunities facing the country’s building and construction industry in coming decades. [...]
Reducing the Cost of Proton Radiation Therapy: The Feasibility of a Streamlined Treatment Technique for Prostate Cancer
Authors: Newhauser Wayne , Zhang Rui , Jones Timothy , Giebeler Annelise , Taddei Phillip , Stewart Robert , Lee Andrew , Vassiliev Oleg
Published: April 2015

Proton radiation therapy is an effective modality for cancer treatments, but the cost of proton therapy is much higher compared to conventional radiotherapy and this presents a formidable barrier to most clinical practices that wish to offer proton therapy. Little attention in literature has been paid to the costs associated with collimators, range compensators and hypofractionation. The objective of this study was to evaluate the feasibility of cost-saving modifications to the present standard of care for proton treatments for prostate cancer. In particular, we quantified the dosimetric impact of a treatment technique in which custom fabricated collimators were replaced with a multileaf collimator (MLC) and the custom range compensators (RC) were eliminated. The dosimetric impacts of these modifications were assessed for 10 patients with a commercial treatment planning system (TPS) and confirmed with corresponding Monte Carlo simulations. We assessed the impact on lifetime risks of radiogenic second cancers using detailed dose reconstructions and predictive dose-risk models based on epidemiologic data. We also performed illustrative calculations, using an isoeffect model, to examine the potential for hypofractionation. Specifically, we bracketed plausible intervals of proton fraction size and total treatment dose that were equivalent to a conventional photon treatment of 79.2 Gy in 44 fractions. Our results revealed that eliminating the RC and using an MLC had negligible effect on predicted dose distributions and second cancer risks. Even modest hypofractionation strategies can yield substantial cost savings. Together, our results suggest that it is feasible to modify the standard of care to increase treatment efficiency, reduce treatment costs to patients and insurers, while preserving high treatment quality.
Simulation Frameworks for Morphogenetic Problems
Authors: Tanaka Simon
Published: April 2015

Morphogenetic modelling and simulation help to understand the processes by which the form and shapes of organs (organogenesis) and organisms (embryogenesis) emerge. This requires two mutually coupled entities: the biomolecular signalling network and the tissue. Whereas the modelling of the signalling has been discussed and used in a multitude of works, the realistic modelling of the tissue has only started on a larger scale in the last decade. Here, common tissue modelling techniques are reviewed. Besides the continuum approach, the principles and main applications of the spheroid, vertex, Cellular Potts, Immersed Boundary and Subcellular Element models are discussed in detail. In recent years, many software frameworks, implementing the aforementioned methods, have been developed. The most widely used frameworks and modelling markup languages and standards are presented.
Modeling Forest Lightning Fire Occurrence in the Daxinganling Mountains of Northeastern China with MAXENT
Authors: Chen Feng , Du Yongsheng , Niu Shukui , Zhao Jinlong
Published: April 2015

Forest lightning fire is a recurrent and serious problem in the Daxinganling Mountains of northeastern China. Information on the spatial distribution of fire danger is needed to improve local fire prevention actions. The Maxent (Maximun Entropy Models), which is prevalent in modeling habitat distribution, was used to predict the possibility of lightning fire occurrence in a 1 × 1 km grid based on history fire data and environment variables in Daxinganling Mountains during the period 2005–2010.We used a jack-knife test to assess the independent contributions of lightning characteristics, meteorological factors, topography and vegetation to the goodness-of-fit of models and evaluated the prediction accuracy with the kappa statistic and AUC (receiver operating characteristic curve) analysis. The results showed that rainfall, number of strikes and lightning current intensity were major factors, and vegetation and geographic variable were secondary, in affecting lightning fire occurrence. The predicted model performs well in terms of accuracy, with an average AUC and maximum kappa value of 0.866 and 0.782, respectively, for the validation sample. The prediction accuracy also increased with the sample size. Our study demonstrated that the Maxent model can be used to predict lightning fire occurrence in the Daxinganling Mountains. This model can provide guidance to forest managers in spatial assessment of daily fire danger.
Community, State, and Federal Approaches to Cumulative Risk Assessment: Challenges and Opportunities for Integration
Authors: Barzyk Timothy , Wilson Sacoby , Wilson Anthony
Published: April 2015

Community, state, and federal approaches to conventional and cumulative risk assessment (CRA) were described and compared to assess similarities and differences, and develop recommendations for a consistent CRA approach, acceptable across each level as a rigorous scientific methodology, including partnership formation and solution development as necessary practices. Community, state, and federal examples were described and then summarized based on their adherence to CRA principles of: (1) planning, scoping, and problem formulation; (2) risk analysis and ranking, and (3) risk characterization, interpretation, and management. While each application shared the common goal of protecting human health and the environment, they adopted different approaches to achieve this. For a specific project-level analysis of a particular place or instance, this may be acceptable, but to ensure long-term applicability and transferability to other projects, recommendations for developing a consistent approach to CRA are provided. This approach would draw from best practices, risk assessment and decision analysis sciences, and historical lessons learned to provide results in an understandable and accepted manner by all entities. This approach is intended to provide a common ground around which to develop CRA methods and approaches that can be followed at all levels.
A Comparison of Direct and Two-Stage Transportation of Patients to Hospital in Poland
Authors: Rosiek Anna , Rosiek-Kryszewska Aleksandra , Leksowski Łukasz , Leksowski Krzysztof
Published: April 2015

Background: The rapid international expansion of telemedicine reflects the growth of technological innovations. This technological advancement is transforming the way in which patients can receive health care. Materials and Methods: The study was conducted in Poland, at the Department of Cardiology of the Regional Hospital of Louis Rydygier in Torun. The researchers analyzed the delay in the treatment of patients with acute coronary syndrome. The study was conducted as a survey and examined 67 consecutively admitted patients treated invasively in a two-stage transport system. Data were analyzed statistically. Results: Two-stage transportation does not meet the timeframe guidelines for the treatment of patients with acute myocardial infarction. Intervals for the analyzed group of patients were statistically significant (p < 0.0001). Conclusions: Direct transportation of the patient to a reference center with interventional cardiology laboratory has a significant impact on reducing in-hospital delay in case of patients with acute coronary syndrome. Perspectives: This article presents the results of two-stage transportation of the patient with acute coronary syndrome. This measure could help clinicians who seek to assess time needed for intervention. It also shows how time from the beginning of pain in chest is important and may contribute to patient disability, death or well-being.
Lead Isotope Characterization of Petroleum Fuels in Taipei, Taiwan
Authors: Yao Pei-Hsuan , Shyu Guey-Shin , Chang Ying-Fang , Chou Yu-Chen , Shen Chuan-Chou , Chou Chi-Su , Chang Tsun-Kuo
Published: April 2015

Leaded gasoline in Taiwan was gradually phased out from 1983 to 2000. However, it is unclear whether unleaded gasoline still contributes to atmospheric lead (Pb) exposure in urban areas. In this study, Pb isotopic compositions of unleaded gasolines, with octane numbers of 92, 95, 98, and diesel from two local suppliers in Taipei were determined by multi-collector inductively coupled plasma mass spectrometry with a two-sigma uncertainty of ± 0.02 %. Lead isotopic ratios of vehicle exhaust (208Pb/207Pb: 2.427, 206Pb/207Pb: 1.148, as estimated from petroleum fuels) overlap with the reported aerosol data. This agreement indicates that local unleaded petroleum fuels, containing 10–45 ng·Pb·g−1, are merely one contributor among various sources to urban aerosol Pb. Additionally, the distinction between the products of the two companies is statistically significant in their individual 208Pb/206Pb ratios (p-value < 0.001, t test). Lead isotopic characterization appears to be applicable as a “fingerprinting” tool for tracing the sources of Pb pollution.
Open Geospatial Education
Authors: Belgiu Mariana , Strobl Josef , Wallentin Gudrun
Published: April 2015

The advances in open data, free and open source software solutions and open access to research publications have influenced the emergence of open educational resources (OER) initiatives. These initiatives permit access to openly licensed learning resources including courses, webinars, training materials and textbooks. Thereby, an increasing number of users has the opportunity to broaden their knowledge and gain new skills. The goal of this paper is to evaluate open education initiatives in the geospatial domain and its synergies with open spatial data and software movements. The paper is focusing on the Massive Open Online Course (MOOCs) movement. The advantages and challenges of open geospatial education will be thoroughly discussed.
In Vitro and in Vivo Antitumoral Effects of Combinations of Polyphenols, or Polyphenols and Anticancer Drugs: Perspectives on Cancer Treatment
Authors: Fantini Massimo , Benvenuto Monica , Masuelli Laura , Frajese Giovanni , Tresoldi Ilaria , Modesti Andrea , Bei Roberto
Published: April 2015

Carcinogenesis is a multistep process triggered by genetic alterations that activate different signal transduction pathways and cause the progressive transformation of a normal cell into a cancer cell. Polyphenols, compounds ubiquitously expressed in plants, have anti-inflammatory, antimicrobial, antiviral, anticancer, and immunomodulatory properties, all of which are beneficial to human health. Due to their ability to modulate the activity of multiple targets involved in carcinogenesis through direct interaction or modulation of gene expression, polyphenols can be employed to inhibit the growth of cancer cells. However, the main problem related to the use of polyphenols as anticancer agents is their poor bioavailability, which might hinder the in vivo effects of the single compound. In fact, polyphenols have a poor absorption and biodistribution, but also a fast metabolism and excretion in the human body. The poor bioavailability of a polyphenol will affect the effective dose delivered to cancer cells. One way to counteract this drawback could be combination treatment with different polyphenols or with polyphenols and other anti-cancer drugs, which can lead to more effective antitumor effects than treatment using only one of the compounds. This report reviews current knowledge on the anticancer effects of combinations of polyphenols or polyphenols and anticancer drugs, with a focus on their ability to modulate multiple signaling transduction pathways involved in cancer.
Insights on Structural Characteristics and Ligand Binding Mechanisms of CDK2
Authors: Li Yan , Zhang Jingxiao , Gao Weimin , Zhang Lilei , Pan Yanqiu , Zhang Shuwei , Wang Yonghua
Published: April 2015

Cyclin-dependent kinase 2 (CDK2) is a crucial regulator of the eukaryotic cell cycle. However it is well established that monomeric CDK2 lacks regulatory activity, which needs to be aroused by its positive regulators, cyclins E and A, or be phosphorylated on the catalytic segment. Interestingly, these activation steps bring some dynamic changes on the 3D-structure of the kinase, especially the activation segment. Until now, in the monomeric CDK2 structure, three binding sites have been reported, including the adenosine triphosphate (ATP) binding site (Site I) and two non-competitive binding sites (Site II and III). In addition, when the kinase is subjected to the cyclin binding process, the resulting structural changes give rise to a variation of the ATP binding site, thus generating an allosteric binding site (Site IV). All the four sites are demonstrated as being targeted by corresponding inhibitors, as is illustrated by the allosteric binding one which is targeted by inhibitor ANS (ﬂuorophore 8-anilino-1-naphthalene sulfonate). In the present work, the binding mechanisms and their fluctuations during the activation process attract our attention. Therefore, we carry out corresponding studies on the structural characterization of CDK2, which are expected to facilitate the understanding of the molecular mechanisms of kinase proteins. Besides, the binding mechanisms of CDK2 with its relevant inhibitors, as well as the changes of binding mechanisms following conformational variations of CDK2, are summarized and compared. The summary of the conformational characteristics and ligand binding mechanisms of CDK2 in the present work will improve our understanding of the molecular mechanisms regulating the bioactivities of CDK2.
Graph Regularized Within-Class Sparsity Preserving Projection for Face Recognition
Authors: Lou Songjiang , Zhao Xiaoming , Guo Wenping , Chen Ying
Published: April 2015

As a dominant method for face recognition, the subspace learning algorithm shows desirable performance. Manifold learning can deal with the nonlinearity hidden in the data, and can project high dimensional data onto low dimensional data while preserving manifold structure. Sparse representation shows its robustness for noises and is very practical for face recognition. In order to extract the facial features from face images effectively and robustly, in this paper, a method called graph regularized within-class sparsity preserving analysis (GRWSPA) is proposed, which can preserve the within-class sparse reconstructive relationship and enhances separatability for different classes. Specifically, for each sample, we use the samples in the same class (except itself) to represent it, and keep the reconstructive weight unchanged during projection. To preserve the manifold geometry structure of the original space, one adjacency graph is constructed to characterize the interclass separability and is incorporated into its criteria equation as a constraint in a supervised manner. As a result, the features extracted are sparse and discriminative and helpful for classification. Experiments are conducted on the two open face databases, the ORL and YALE face databases, and the results show that the proposed method can effectively and correctly find the key facial features from face images and can achieve better recognition rate compared with other existing ones.
NAPPA as a Real New Method for Protein Microarray Generation
Authors: Díez Paula , González-González María , Lourido Lucía , Dégano Rosa , Ibarrola Nieves , Casado-Vela Juan , LaBaer Joshua , Fuentes Manuel
Published: April 2015

Nucleic Acid Programmable Protein Arrays (NAPPA) have emerged as a powerful and innovative technology for the screening of biomarkers and the study of protein-protein interactions, among others possible applications. The principal advantages are the high specificity and sensitivity that this platform offers. Moreover, compared to conventional protein microarrays, NAPPA technology avoids the necessity of protein purification, which is expensive and time-consuming, by substituting expression in situ with an in vitro transcription/translation kit. In summary, NAPPA arrays have been broadly employed in different studies improving knowledge about diseases and responses to treatments. Here, we review the principal advances and applications performed using this platform during the last years.
Nitric Oxide Plays a Central Role in Water Stress-Induced Tanshinone Production in Salvia miltiorrhiza Hairy Roots
Authors: Du Xuhong , Zhang Chenlu , Guo Wanli , Jin Weibo , Liang Zongsuo , Yan Xijun , Guo Zhixin , Liu Yan , Yang Dongfeng
Published: April 2015

Nitric oxide (NO), a well-known signaling molecule plays an important role in abiotic and biotic stress-induced production of plant secondary metabolites. In this study, roles of NO in water stress-induced tanshinone production in Salvia miltiorrhiza hairy roots were investigated. The results showed that accumulations of four tanshinone compounds in S. miltiorrhiza hairy roots were significantly stimulated by sodium nitroprusside (SNP, a NO donor) at 100 μM. Effects of SNP were just partially arrested by the mevalonate (MVA) pathway inhibitor (mevinolin), but were completely inhibited by the 2-C-methyl-d-erythritol-4-phosphate pathway (MEP) inhibitor (fosmidomycin). The increase of tanshinone accumulation and the up-regulation of HMGR and DXR expression by PEG and ABA treatments were partially inhibited by an inhibitor of NO biosynthesis (Nω-nitro-L-arginine methyl ester (L-NAME)) and a NO scavenger (2-(4-Carboxyphenyl)- 4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide (c-PTIO)). Simultaneously, NO generation in the hairy roots was triggered by PEG and ABA, and the effects were also arrested by c-PTIO and L-NAME. These results indicated that NO signaling probably plays a central role in water stress-induced tanshinone production in S. miltiorrhiza hairy roots. SNP mainly stimulated the MEP pathway to increase tanshinone accumulation.
Overexpression of a Gene Involved in Phytic Acid Biosynthesis Substantially Increases Phytic Acid and Total Phosphorus in Rice Seeds
Authors: Tagashira Yusuke , Shimizu Tomoe , Miyamoto Masanobu , Nishida Sho , Yoshida Kaoru
Published: April 2015

The manipulation of seed phosphorus is important for seedling growth and environmental P sustainability in agriculture. The mechanism of regulating P content in seed, however, is poorly understood. To study regulation of total P, we focused on phytic acid (inositol hexakisphosphate; InsP6) biosynthesis-related genes, as InsP6 is a major storage form of P in seeds. The rice (Oryza sativa L.) low phytic acid mutant lpa1-1 has been identified as a homolog of archael 2-phosphoglycerate kinase. The homolog might act as an inositol monophosphate kinase, which catalyzes a key step in InsP6 biosynthesis. Overexpression of the homolog in transgenic rice resulted in a significant increase in total P content in seed, due to increases in InsP6 and inorganic phosphates. On the other hand, overexpression of genes that catalyze the first and last steps of InsP6 biosynthesis could not increase total P levels. From the experiments using developing seeds, it is suggested that the activation of InsP6 biosynthesis in both very early and very late periods of seed development increases the influx of P from vegetative organs into seeds. This is the first report from a study attempting to elevate the P levels of seed through a transgenic approach.
A Prototype Network for Remote Sensing Validation in China
Authors: Ma Mingguo , Che Tao , Li Xin , Xiao Qing , Zhao Kai , Xin Xiaoping
Published: April 2015

Validation is an essential and important step before the application of remote sensing products. This paper introduces a prototype of the validation network for remote sensing products in China (VRPC). The VRPC aims to improve remote sensing products at a regional scale in China. These improvements will enhance the applicability of the key remote sensing products in understanding and interpretation of typical land surface processes in China. The framework of the VRPC is introduced first, including its four basic components. Then, the basic selection principles of the observation sites are described, and the principles for the validation of the remote sensing products are established. The VRPC will be realized in stages. In the first stage, four stations that have improved remote sensing observation facilities have been incorporated according to the selection principles. Certain core observation sites have been constructed at these stations. Next the Heihe Station is introduced in detail as an example. The three levels of observation (the research base, pixel-scale validation sites, and regional coverage) adopted by the Heihe Station are carefully explained. The pixel-scale validation sites with nested multi-scale observation systems in this station are the most unique feature, and these sites aim to solve some key scientific problems associated with remote sensing product validation (e.g., the scale effect and scale transformation). Multi-year of in situ measurements will ensure the high accuracy and inter-annual validity of the land products, which will provide dynamic regional monitoring and simulation capabilities in China. The observation sites of the VRPC are open, with the goal of increasing cooperation and exchange with global programs.