bluuebunny/crossref_metadata_2025 huggingface dataset:
Construction of a survival model for Esophageal Squamous Carcinoma and prediction of potential treatment with herbal medicine
Authors: Zhang Zhenhu , Zhang Guodong , Xiao Zhaohua , Mao Xinyu , wang Dong
Published: June 2023

Purpose
Esophageal squamous cell carcinoma (ESCC) accounts for 80% of esophageal cancers worldwide, with a 5-year survival rate of only 30%. Herbal medicine has been extensively used in Asian medicine for more than 5000 years, yet little is known about its application in ESCC. Zhenqi Fuzheng Granules (ZQFZ) is a classic Chinese herbal formula used to improve immunity, but research on the mechanism is lacking.
Methods
We verified 25 ZQFZ substances from the Traditional Chinese Medicine System Pharmacology (TCMSP) database for this study, downloaded GSE20347 and GSE38129 datasets from the GEO database to find the targets of ESCC, and plotted Venn diagrams to obtain the co-targets of ZQFZ and ESCC. GO and GSEA enrichment analyses have been performed to look into the levels of expression and biological functions of the key genes. Key targets were obtained using the LASSO machine learning algorithm and the cytoHubba plugin in Cytoscape 3.8.2, respectively, and further validated with datasets GSE45670, GSE161533, and the GEPIA database. Immune infiltration analysis was performed using the CIBERSORTx algorithm and correlations between core targets and common immunosuppressive checkpoints were analyzed using Pearson correlation coefficients to explore the immune function and validated using the TIMER 2.0 database. Data on esophageal squamous cancer survival was obtained from the TCGA database, and key genes were evaluated using univariate and multivariate Cox analyses. Differential genes were then added to create a Nomogram analysis. To further assess the potential effects of the selected drugs on ESCC, molecular docking was performed.
Results
From the 35 differential genes, we extracted 5 of the most closely related genes and 6 of the prognosis-related genes, respectively. Immunoassay showed that CXCL10 was closely associated with immune infiltration, while the CHEK1 gene was associated with patient survival prognosis. The 11 core genes were analyzed and docked one by one, showing good results.
Conclusion
In conclusion, ZQFZ may act through multiple pathways on a range of targets to treat ESCC. This study presents a novel method for treating ESCC and lays the basis for ZQFZ clinical application.
Icodextrin– induced acute generalized exanthematous pustulosis in a patient with peritoneal dialysis
Authors: Liu Chun-Hao , Chen Chien-Chou , Sung Chih-Chien
Published: June 2023

Icodextrin is widely utilized as an osmotic agent in peritoneal dialysis (PD) prescription for clinical patients with inadequate ultrafiltration, but icodextrin induced acute generalized exanthematous pustulosis (AGEP) has not been well recognized. We described a young-aged female with IgA nephropathy under continuous automated peritoneal dialysis who developed skin erythema with exfoliation over the groin at 7th day after first infusion of icodextrin based PD prescription. Her scaling skin lesion with pinhead-sized pustules invaded the bilateral inguinal folds at first, and then extended to general trunk accompanied by pruritus and mild tingly in rapid succession. As expansion of confluent skin lesion, she was admitted on 14th day of icodextrin exposure and PD treatment was instantly ceased. She was afebrile with stable vital sign and physical examination was notable for widespread erythematous papules with pruritus extending over her groins, abdomen and back. Pertinent laboratory examination showed leukocytosis of 18970 cells/μL with neutrophile count of 17642 cells/μL (92.3 %), and c-reactive-protein: 3.39 mg/dl. Skin biopsy reveals multifocal subcorneal abscess with papillary dermal edema, and upper-dermal neutrophilia with perivascular accentuation, consistent with the diagnosis of AGEP. After discontinuation of PD, she underwent temporary high-flux hemodialysis and treatment of steroid and antihistamine, her dermatologic lesion resolved totally four days later and restarted peritoneal dialysis at 17th day without any skin sequalae. This case highlighted the fact that icodextrininduced AGEP should be early recognized after first use of icodextrin to avoid misdiagnosis to other dermatoses and severe complication without appropriate management.
WITHDRAWN: Glycaemic index and glycaemic load values of Thai geographical indication rice cultivars
Authors: Srik Khongsak , Srik Wararat
Published: June 2023

Glycaemic index of white rice is generally high; however, it varies in brown or pigmented rice. The purpose of this study was to ascertain the glycaemic indices and glycaemic loads of rice varieties registered as Thai geographical indication (GI) rice. Ten Thai GI rice samples, differing in properties and colors; Kum Lanna, Rai Leum Pua Petchabun, Kalasin Kaowong, Hom Mali Phayao, Hom Mali Thung Kula Rong-Hai, Hom Mali Surin, Leuang Patew Chumphon, Rai Dawk Kha Phangnga, Sangyod Muang Phatthalung, and Jek Chuey Sao Hai were analyzed for their glycaemic index responses using the standard in-vivo method. It was found that Thai GI rice varieties exhibited medium to high glycaemic indices and all samples showed high glycaemic load values (>20). The glycamic indices ranged from 62 (Sangyod Muang Phatthalung) to 82 (Kalasin Kaowong). Glycemic indices were discovered to be primarily impacted by variety rather than geography. The findings of this study updated the glycemic index database of special rice types, allowing consumers to select healthier rice.
Impact of residual coronary lesions on outcomes of myocardial infarction patients with multi-vessel disease
Authors: Ahmed Tarek A. N. , Othman Amr A. A. , Demitry Salwa R. , El-Maghraby Khaled M.
Published: June 2023

Background
Interest grew in residual disease burden after percutaneous coronary intervention (PCI). The residual SYNTAX score (rSS) is a strong prognostic factor of coronary events and all-cause death in patients who underwent PCI. Its derivative, the SYNTAX Revascularization Index (SRI), has been used in determining the proportion of coronary artery disease (CAD) that has been treated and has been shown to have prognostic utility in PCI for patients with multi-vessel disease (MVD).
Purpose
We sought to assess the use of the rSS and the SRI as predictors for in-hospital outcomes and up to two-year cumulative follow-up outcomes in patients with multi-vessel disease (MVD) who underwent PCI in the setting of ST-Elevation Myocardial Infarction (STEMI) or Non-STEMI (NSTEMI).
Methods
We recruited 149 patients with either STEMI or NSTEMI in the setting of MVD who underwent PCI. We divided them into tertiles, based on their rSS and SRI values, respectively. We calculated bSS and rSS using the latest version of the web-based calculator, and from these scores we calculated SRI. The endpoints were: In-hospital composite MACE and its components, in-hospital mortality, follow-up cumulative MACE up to 2-years.
Results
rSS and SRI were not significant predictors of in-hospital death or MACE, while female sex hypertension, and left ventricular ejection fraction were independent predictors of in-hospital MACE. At two-year follow-up, Kaplan-Meier analysis showed significantly increased incidence of death and MACE within the third rSS tertile (rSS > 12) compared to the other tertiles (log rank p = 0.03), while there was no significant difference between the three SRI tertiles. rSS was a significant predictor of death and MACE on univariate Cox regression analysis. On multivariate Cox regression, rSS was an independent predictor for MACE (HR = 1.04, 95% CI = 1.01–1.06, p = 0.002). Of notice, all patients with complete revascularisation survived throughout the entire follow-up period.
Conclusions
The rSS and SRI were poor predictors of in-hospital death and MACE, while they were good predictors of death and MACE at two-year follow-up, with better overall performance for rSS in comparison to SRI. Patients with rSS values > 12 showed significantly higher incidence of MACE and all-cause mortality at two years. The best prognosis was achieved with complete revascularisation.
How microeconomic factors influence Vietnam’s listed manufacturing firm value
Authors: Lan Le Phuong
Published: June 2023

It is meaningful to identify and quantify the impact of business microeconomic factors on firm value, not only for enterprises, but also for the industry, which contributes to the economic growth of the whole country. This paper aims to find evidence of how microeconomic factors relate to the value of manufacturing firms, helping businesses behave and adjust towards the goal of value maximization. This study applies three commonly used estimators with panel data, namely OLS, FEM and REM, using data obtained from FiinPro (a data providing company) and Vietstock on 691 companies listed on Vietnam’s two stock exchanges from 2008 to 2015; This was a sensitive period of world financial crisis, and Vietnamese manufacturing firms had a really hard time to overcome the difficulty in a global economy downturn. This paper found that (1) firm size, growth opportunities and financial leverage negatively affect firm value; (2) there is no evidence that operating cash flow, cash liquidity and intellectual capital affect firm value; (3) the estimation results confirm the non-linear relationship (order 3) between the directors’ share ownership ratio and corporate value; (4) state ownership and foreign ownership ratios have a negative effect on Vietnamese listed manufacturing firms during the period, but (5) there is no optimal number of BOD members. The findings help to measure the extent of the positive and negative impact of various factors, making it easier to find solutions to improve business value by promoting positive factors and preventing negative factors.
A safe approach to the treatment of type 2 diabetes in elderly patients
Authors: Bulgakova S. V. , Bashinskaya S. A. , Dolgikh Y. A. , Sharonova L. A. , Kosareva O. V. , Treneva E. V. , Kurmayev D. P. , Sirotko I. I.
Published: June 2023

Introduction. Type  2 diabetes is a  significant medical problem. The solution to this problem lies not only in  lowering the patient’s blood glucose level, but also in preventing the complications of diabetes, influencing insulin resistance and normalizing body weight.

Aim. To develop an effective and safe treatment regimen for elderly women with type 2 diabetes, which is aimed at compensating carbohydrate metabolism, improving lipid metabolism and anthropometric parameters.

Materials and methods. The study involved 80 women with type 2 diabetes aged 60 to 74 years, who were divided into 2 groups of 40 people. Group 1 included patients with type 2 diabetes receiving traditional therapy for type 2 diabetes. Patients of the group 2 received the method of treatment developed by us, including, in addition to the traditional regimen, the drug Subetta®, cholecalciferol drops. All women collected complaints and anamnesis, assessed anthropometric parameters, glucose, glycated hemoglobin, vitamin D, lipid profile.

Results. All patients with type 2 diabetes initially were not compensated for carbohydrate metabolism, had abdominal obesity, atherogenic dyslipidemia, and vitamin D deficiency. Anthropometric parameters significantly improved, glucose and HbA1c levels decreased to target values in patients of group 2 after 6 months against the background of the use of Subetta® and cholecalciferol. Also in this group, the indicators of lipid metabolism improved: the levels of cholesterol, LDL, triglycerides decreased, and the levels of HDL increased. Vitamin D levels reached target range. No episodes of hypoglycemia were recorded.

Conclusions. The addition of  Subetta® and cholecalciferol to the  treatment of  patients with type  2 diabetes contributed to the achievement of target indicators of carbohydrate metabolism, improved lipid profile, and weight loss. This method of treatment is well tolerated and has a low risk of hypoglycemia, which is especially important for elderly patients.
Metformin and sitagliptin fixed combination as the optimal choice in solving current problems in the type 2 diabetes mellitus treatment
Authors: Biryukova E. V. , Kileynikov D. V.
Published: June 2023

The complex pathogenesis of type 2 diabetes mellitus (DM) is the basis for providing the therapeutic treatment for various disorders, which ensures a better glucose-lowering potential and maintenance of glycemic control as the disease progresses. A key reason for poor glycemic control is clinical inertia, which can be overcome by using antidiabetic fixed-dose combinations (FC). Their use improves glycemic control, as the multidirectional action of the combination components on the pathogenetic mechanisms of type 2 diabetes leads to increased pharmacological effects. The PK of metformin and sitagliptin is preferable in terms of glucose-lowering efficacy, safety and clinical benefits. The mechanism of action of metformin is not associated with the stimulation of insulin secretion by β-cells, but results from the drug’s effect on insulin sensitivity at the level of the liver, muscle and adipose tissue, although the effect on hepatic glucose production is the prevailing one. The mechanism of action of sitagliptin, a highly selective inhibitor of dipeptidyl peptidase-4, is additional to the basic pharmacological effects of metformin, which are caused by several mechanisms not associated with stimulation of insulin secretion by β-cells. The simultaneous use of sitagliptin and metformin has additive effects on the increase of glucagon-like peptide-1 levels. This action is implemented through various mechanisms, while metformin increases the release, and sitagliptin inhibits the active degradation of glucagon-like peptide-1. The article emphasizes the importance of rational combinations of glucose-lowering drugs, the need for a personalized approach to the choice of medicines. The current possibilities of sugar-reducing therapy, the issues of efficacy, safety and benefits of PK of metformin and sitagliptin are discussed using modern evidence-based data.
Neuroprotective potential of incretinomimetics
Authors: Kokin A. S. , Suplotova L. A. , Dushina T. S. , Makarova O. B.
Published: June 2023

In the prescriptions of an endocrinologist to patients with diabetes mellitus, glucagon-like peptide agonists, belonging to the group that affects the incretin system of the body, have recently been increasingly appearing. In addition to the pronounced hypoglycemic effect and high safety, these drugs also have many pleiotropic properties due to the presence of glucagon-like peptide receptors in the vascular endothelium, kidneys, heart and nervous tissue. The purpose of this work is to describe the  most studied neuroprotective effects of  this class of  drugs. As materials in  the course of  the work, studies of domestic and foreign colleagues published in the period from 2008 to 2022 were used. Our work has shown that the neuroprotective effect of GLP-1 is associated with the activation of the corresponding receptor systems in the central nervous system, which leads to increased cellular survival in ischemic conditions by reducing reactive oxygen species, stimulating beta-oxidation by mitochondria, and reducing pro-inflammatory cytokines. In addition, the analysis of the literature also established the positive role of GLP-1 in neurodegenerative diseases – drugs reduce the amount of unnormal proteins (alphasynuclein, microtubular T-peptide, etc.), reduce the activity of non-enzymatic glycation of proteins in hyperglycemia, as well as reduce insulin resistance. The effects described above were analyzed during preclinical trials of GLP-1, and also demonstrated their validity in human models during some clinical trials. However, the data obtained is not yet sufficient to form clear indications for this class of drugs in neurology, so the topic requires further study and large clinical trials.
Cardiac autonomic neuropathy as risk factor of diabetic complications progression
Authors: Salukhov V. V. , Zelenina T. A. , Ismailov D. D. , Zemlianoi A. B.
Published: June 2023

Introduction. Diabetes mellitus (DM) is the most common and incapacitating endocrine disorder. Diabetic foot syndrome (DFS) is one of the most serious complications of DM, which is the main cause of nontraumatic lower-extremity amputations. Despite the efforts of the entire medical community, the survival rate of DFS patients with non-healing ulcers and after foot surgery does not exceed 50% over 5 years and is comparable to the survival rates of patients with colorectal cancer.

Aim. It has been demonstrated that postsurgical diabetic foot wounds tend to chronization of inflammatory process. The diabetic autonomic neuropathy can be involved in diabetic foot damages. We hypothesized that progression of cardiovascular autonomic neuropathy  (CAN) leads to aggressive microvascular complications of  diabetes and delay the  postsurgical wound healing in diabetic foot patients during 2 years of observation.

Materials and methods. We examined 94 outpatients with postsurgical diabetic foot wounds and observation period of two years. The clinical neurological examination and standard cardiovascular autonomic reflex tests with identification of severe/advanced abnormalities were performed at baseline and after 2 years. The progression of CAN was diagnosed in cases of an increase in the amount of cardiovascular autonomic reflex tests by 1 score and more. The unsatisfactory result of wound treatment was detected in patients with wound healing delay and new cases of surgery debridement, foot amputations and Charcot foot during 2 years of observation.

Results. The mean duration of diabetes was 10.7 year, HbA1c 8.3%, LDL-Chol 3.3 mmol/l, TG 1.8 mmol/l. The 51.1% patients had been amputated in the level of foot, 48.9% patients had surgery debridement. All patients had CAN, confirmed/severe forms in 57.4% cases. The progression of CAN was found in 22.3% patients, the most of them with functional stage at baseline. The aggressive course of CAN increased the risk of progression of diabetic sensomotor neuropathy (OR = 14.6; 95% CI 3.0–70.5; p = 0.0006), nephropathy (OR = 22.4; 95% CI 3.4–147.4; p = 0.0009) and unsatisfactory result of wound treatment (OR = 40; 95% CI 6.0–268.5; p = 0.0001).

Conclusions. The patients with diabetic foot surgery wounds has high risk of confirmed/severe CAN and its progression during 2 years. The aggressive course of CAN associates with unsatisfactory result of wound treatment and progression of microvascular diabetic complications.
COVID-19 PANDEMİSİNDE EKONOMİK DURUM VE SOSYAL İZOLASYONUN BİREYLERE ETKİSİ: BURSA İLİ ÖRNEĞİ
Authors: ALTIPARMAK İpek Beyza , AS Aynur
Published: June 2023

Yaşanan döneme ve çağa göre farklılaşan diğer bir deyişle benzer ve farklı yönleri bulunan salgınların sağlık üzerindeki etkileri belirli bir zaman sonra ortadan kalkmaktadır. Yıkıcı ve dönüştürücü etkileri bulunan ve geniş kitleleri etkisi altına alan salgınların sağlık üzerindeki etkilerinin ortadan kalkmasına rağmen toplumsal ve psikolojik etkilerinin salgın sonrasında da devam ettiği bilinmektedir. Buradan hareketle yapılan çalışmada ekonomik, psikolojik ve sosyal alanda değişen etkilerin bireylere yansıması incelenmiştir. Çalışma Bursa ilinde ikamet eden 48 aile ile gerçekleştirilmiştir. Nitel araştırma deseni ile tasarlanan araştırmada verilerin toplanmasında derinlemesine mülakat tekniği kullanılmıştır. Çalışmanın sonucunda pandemi sürecinde ekonomik yoksunluk yaşayan bireylerin ekonomik (temel gereksinimlere ulaşma, barınma, iş kaybı) ve psikolojik (korkular, ilaç kullanımı, manevi destek ihtiyacı, psikolojik hastalıkların artışı) yönden olumsuz olarak etkilendiği ortaya koyulmuştur. Ayrıca çalışma kapsamında pandemi süreci bittikten sonra gerek sosyal hizmet destekleri gerekse istihdam sağlanması bakımından dezavantajlı grupların desteklenmesi gerektiğine yönelik önerilere yer verilmiştir.
Neural solution of elliptic partial differential equation problem for single phase flow in porous media
Authors: Dzidolikas Vilius , Kraujalis Vytautas , Pal Mayur
Published: June 2023

Partial differential equations are used to model fluid flow in porous media. Neural networks can act as equation solution approximators by basing their forecasts on training samples of permeability maps and their corresponding two-point flux approximation solutions. This paper illustrates how convolutional neural networks of various architecture, depth and parameter configurations manage to forecast solutions of the Darcy’s flow equation for various domain sizes.
Sanat ve Sinizm (Yabancılaşma) İlişkisi: George Grosz ve Andy Warhol
Authors: Cengiz Burcu Nur , Akçaoğlu Zeliha
Published: June 2023

Sanatçı ait olduğu toplumun diğer bireyleri gibi iletişim kurabilme ve çevresine karşılık verebilme yetisine bağlı olarak kendisini, benliğini ve sanatsal dilini inşa eder. Bu inşa sürecine kişisel deneyimleri, toplumsal değerleri ve savunma mekanizmaları da ortak olur. Araştırmada savaş, kapitalizm veya sermaye sömürüsü gibi nedenlerle bireyde gelişen sinizm ve yabancılaşma durumları, savunma mekanizmaları sanatçı-toplum dinamiğinde ele alınmakta, George Grosz ve Andy Warhol örnekleri üzerinden incelenmektedir. Grosz’un hicivci üslubu, mizah savunma mekanizmasıyla, Warhol’un kitle imgeleri ve medya ikonografisi, inkar ve özdeşleşme savunma mekanizmalarıyla ilişkilendirilmektedir. Araştırma literatür tarama yöntemi ile gerçekleştirilmiş olup, konuya ilişkin daha önceden gerçekleştirilen araştırmalar incelenmiştir. Ayrıca bu çalışma, George Grosz’un eski avangard, Andy Warhol’un yeni avangard olarak ortak ve farklı yönlerinin karşılaştırmalı değerlendirilmesiyle de önem kazanmaktadır. Araştırmanın ülke vatandaşı ve toplum gözlemcisi olarak sanatçının sahip olduğu ideolojik yaklaşım ve üretimlerinin sosyo-psikolojik bağlantılarının anlaşılabilir olması açısından yardımcı bir kaynak olabileceği düşünülmektedir.
20. Yüzyılda Kaşkaylı Bir Bozkır Ressamı: Bijan Bahadori Keşkuli
Authors: Ayğan Abdurrahim , Mardani Aligholi
Published: June 2023

Bu çalışma İran coğrafyasının kadim Türk topluluklarından biri olan Kaşkaylara mensup ressam Bijan Bahadori Keşkuli'nin sanat anlayışına odaklanmıştır. Kaşkaylar atalarından devraldıkları sözlü mirası, el sanatlarını, inanç biçimlerini, töre ve geleneklerini modern zamanlara kadar taşımışlardır. Kaşkay kültürünün bu yalın hali özellikle antropologların dikkatini çekmiş ve bu konuda araştırmalar yapmışlardır. Fakat eserleri bugün İran ve Avrupa’nın farklı müze ve özel koleksiyonlarında yer alan ressam Bijan Bahadori hakkında herhangi bir müstakil çalışma yapılmamış ve antropolojik çalışmalarda da eserlerine değinilmemiştir. Bijan Bahadori Keşkuli’nin bütün eserleri kendi kültürüne ait belge niteliği taşıyan çalışmalardır. 1970’lerden sonra hızla değişen ve modernleşmeye başlayan Kaşkayların geleneksel sosyal yapısına dair birçok unsuru kaydetmeyi başarmıştır. Kaşkay kültürü, gelenekleri, ritülleri, merasimleri ve göçebe yaşam pratikleri resimlerinin ana temalarındandır. Çok iyi bir gözlemci olarak yaşadığı coğrafyayı, doğayı, insanları, hayvanları, el sanatı üretimlerini kendine özgü bezemeci bir üslupla resimlerine yansıtmıştır. Bu çalışma kapsamında, sanatçının İran Meshkin Fam Müzesi’ndeki eserleri ile oğlu Siroos Bahadori’nin koleksiyonunda bulunan eserler betimleyici bir perspektifle incelenmiştir. Sanatçının incelenen eserleri çerçevesinde belirli başlıklar altında estetik anlayışının ortaya çıkarılması amaçlanmıştır.
The Association between Vitamin D Deficiency and Fibrocystic
Breast Disorder
Authors: Shabanian Sheida , Rozbeh Aliyeh , Mohammadi Belgheis , Ahmadi Ali , Arjmand Mohammad-Hassan
Published: June 2023

Background:

The role of deficiency of vitamin D in a wide range of human
cancer, including breast cancer, has been proven, but its role in benign breast diseases
remains unknown. This study aimed to determine the prevalence of vitamin D deficiency
in patients with fibrocystic breast (FB) disease.

Methods:

First, the hospital prevalence of fibrocystic breast was determined by a crosssectional
study. Then, patients were divided into two groups by a case-control study;
women with confirmed fibrocystic breasts based on breast pain, physical examination,
and ultrasonography were included as a case group (N=48), and age-matched women
without fibrocystic breasts were also included as a control group (N=48). After recording
the demographic and gynecological characteristics and exposure to the sun,
gynecological records, and family history of fibrocystic breast, the blood sample was
taken to determine vitamin D. Data were analyzed by Stata software.

Results:

The result indicated that the studied groups had significant differences in
regards to weight, breast pain, the severity of breast pain, breast heaviness, family
history of fibrocystic breast, history of breast disease, caffeine consumption, and
exposure to sunlight (p <0.05), but did not show significant differences based on age,
occupation, education, gynecological history, diabetes mellitus, hypertension, obesity
and hypothyroidism, vegetable, fast food, and dairy products consumption. The
frequency of vitamin D deficiency in the case group was 45.8%, and in the control group,
it was 20.8%, and there was a statistically significant difference (p <0.05).

Conclusion:

Vitamin D deficiency is more common in women with fibrocystic breast
disease and may play a role in the development of the disease.
Recent Advances in Computer-aided Virtual Screening and Docking
Optimization for Aptamer
Authors: Liu Yijie , Yang Jie , Chen Meilun , Lu Xiaoling , Wei Zheng , Tang Chunhua , Yu Peng
Published: June 2023

Aptamers, as artificially synthesized short nucleotide sequences, have been widely used in protein analysis, gene engineering, and molecular diagnostics. Currently, the screening process of aptamers still relies on the traditional SELEX process, which is cumbersome and complex. Moreover, the success rate of aptamer screening through the SELEX process is not high, which has become a major challenge. In recent years, the development of computers has facilitated virtual screening, which can greatly accelerate the screening process of aptamers through computer-assisted screening. However, the accuracy and precision of current virtual screening software on the market vary. Therefore, this work summarizes the docking characteristics of four mainstream molecular docking software programs, including Auto dock, Auto dock Vina, MOE, and hex Dock, in recent years. Moreover, the accuracy and prediction performance of these four molecular docking software programs for aptamer docking based on experimental data is also evaluated. This will guide researchers in the selection of molecular docking software. Additionally, this review provides a detailed overview of the application of computer-aided virtual screening in aptamer screening, thus providing a direction for future development in this field.
A Case Report on COVID-19 Causing New Onset of Diabetes Even with
No History
Authors: Vohra Manisha , Amir Mohammad , Osoro Ian , Sharma Amit
Published: June 2023

This case report presents a case of a 51-year-old male patient who was found to be diabetic
after recovering from COVID-19. Case Presentation: The patient was admitted to the COVID care center
after testing positive for COVID-19 on November 2020. After spending one week in intensive care and
ten days in the isolation ward of the COVID care center, he continued to feel multiple side effects. After
fifteen days, he began showing signs of recovery and had no fever or other symptoms of COVID-19. The
third SARS-Cov-2 RNA by RT-PCR sample test was also found to be negative. He was shifted to a non-
COVID hospital when he became stable. For COVID-19, he was treated with supplementary oxygen therapy
by keeping his oxygen level at 5L/min with titrating flow rate SpO2 of more than 90%. The hydroxychloroquine
400 mg orally BD for two days, followed by 200 mg orally BD for four days with a
combination of azithromycin 500 mg orally OD for five days, was prescribed to him to treat COVID-19.
Conclusion: According to the report "New-onset diabetes in COVID-19," published in the New England
Journal of Medicine, there is a bidirectional relationship between COVID-19 and diabetes.
Development of Hybrid Bio-inspired Computing Algorithms for Design of Fractal Antennas
Authors: Dhaliwal Balwinder S. , Pattnaik Suman , Pattnaik Shyam Sundar
Published: June 2023

One of the novel contributions of this book is the development of hybrid
bio-inspired computing algorithms for the design of fractal antennas. This work is
presented in this chapter. The hybrid algorithms are developed to design the proposed
fractal antennas for desired frequencies. The performance comparison of bio-inspired
computing algorithms for the design of a multiband Sierpinski Gasket fractal antenna is
also explained. The development of various hybrid algorithms like the GA-ANN
hybrid Algorithm, BFO-ANN ensemble hybrid Algorithm, and PSO-ANN Ensemble
hybrid Algorithm is explained. The use of ANN models as objective functions of
optimization algorithms is discussed in this chapter. This chapter also deals with the
experimental testing and validation of the developed fractal antennas. The photographs
of the fabricated antennas and the experimental results are included. The comparison of
the simulated results and experimental results is discussed. The suitability of the
designed antennas for different applications is also highlighted in this chapter. 
Fractal Antenna Design using Bio-inspired Computing Algorithms
Authors: Dhaliwal Balwinder S. , Pattnaik Suman , Pattnaik Shyam Sundar
Published: June 2023

This book presents research focused on the design of fractal antennas using bio-inspired computing techniques. The authors present designs for fractal antennas having desirable features like size reduction characteristics, enhanced gain, and improved bandwidths. The research is summarized in six chapters which highlight the important issues related to fractal antenna design and the mentioned computing techniques. Chapters demonstrate several applied concepts and techniques used in the process such as Artificial Neural Networks (ANNs), Genetic Algorithms (GAs), Particle Swarm Optimization (PSO) and Bacterial Foraging Optimization (BFO). The work aims to provide cost-effective and efficient solutions to the demand for compact antennas due to the increasing demand for reduced sizes of components in modern wireless communication devices.

A key feature of the book includes an extensive literature survey to understand the concept of fractal antennas, their features, and design approaches. Another key feature is the systematic approach to antenna design. The book explains how the IE3D software is used to simulate various fractal antennas, and how the results can be used to select a design. This is followed by ANN model development and testing for optimization, and an exploration of ANN ensemble models for the design of fractal antennas.

The bio-inspired computing techniques based on GA, PSO, and BFO are developed to find the optimal design of the proposed fractal antennas for the desired applications. The performance comparison of the given computing techniques is also explained to demonstrate how to select the best algorithm for a given bio-inspired design. Finally, the book explains how to evaluate antenna designs.

This book is a valuable resource for students (from UG to PG levels) and research scholars undertaking learning modules or projects on microstrip and patch antenna design in communications or electronics engineering courses.
Understanding Ourselves in Times of Climate Change
Authors: Mees Roland
Published: June 2023

Understanding Ourselves in Times of Climate Change When it comes to fighting climate change, any strategy to reach "net zero" by 2050 is credible only if it includes a commitment to reduce greenhouse gas emissions by 50 percent by 2030. Although the affluent countries have been aware of the climate challenge since 1992, they have waited too long to take sustainable action. Our failure as people in the affluent countries to act sustainably is incompatible with how we understand ourselves as we shape visionary companies by relentlessly improving business processes, product quality and customer experience. Visionary companies deliver the best performance to their stakeholders. Why are we able to do all this, but ineffective in taking climate action? As I see it, we apply different moral standards to future generations than we do to current generations. This hinders us from gaining the virtue of moral integrity. Only when we evaluate our roles as individuals, professionals in organisations, and members of humanity as against an integral set of normative standards can we be regarded as persons of integrity. Despite these concerns, there are institutions that can overcome the motivational weaknesses of people in the affluent countries to take sustainable action and limit global warming to 1.5 degrees Celsius. For example, we must cherish the institutions that make up our constitutional democracies. We should support the EU Fit-for-55 ambition, and we should welcome the Dutch Civil Code, which offers opportunities to compel individuals and companies to take climate action.
ISOLASI DAN IDENTIFIKASI KAPANG ENDOFIT DARI POHON SENGON PROVENAN KEPULAUAN SOLOMON BERDASARKAN MORFOLOGI DAN MOLEKULER (ANALISIS rDNA ITS (INTERNAL TRANSCRIBED SPACER)
Authors: Nuryadi H Wahyu , Rakhmawati Anna , Prihatini Istiana
Published: June 2023

Kapang endofit merupakan organisme yang memiliki potensi sebagai agen hayati pengendali hama patogen pada tanaman. Perlu adanya penelitian untuk mengisolasi dan mengidentifikasi kapang endofit dari jaringan tanaman yang diketahui memiliki tingkat resistensi terhadap suatu penyakit. Penelitian ini bertujuan untuk mengisolasi dan mengidentifikasi kapang endofit dari pohon sengon provenan Kepulauan Solomon menggunakan analisis rDNA ITS, serta mempelajari karakter morfologi isolat yang berhasil diisolasi. Isolasi kapang endofit dilakukan dengan cara menanam bagian bagian daun, tangkai daun, ranting dan kulit batang pohon sengon pada media MEA, kultur tunggal isolat kapang endofit diidentifikasi berdasarkan morfologi dan molekuler pada sekuen rDNA ITS (ITS1-5.8S-ITS2). Hasil penelitian ini mendapatkan 28 isolat kapang endofit, namun hanya 26 isolat yang menunjukkan hasil sequencing yang baik dan digunakan untuk proses analisis filogenetik. Hasil identifikasi diperoleh sebanyak 4 isolat teridentifikasi sebagai genus Lasiodiplodia, 4 isolat sebagai famili Didymellaceae, 11 isolat teridentifikasi sebagai genus Phompopsis, 5 isolat sebagai genus Colletotrichum, 1 isolat sebagai genus Nemania, dan 1 isolat sebagai genus Xylaria. Kata kunci: Kapang Endofit, Morfologi Kapang, Analisis rDNA ITS, Sengon Provenan Kepulauan Solomon.
KUALITAS PERAIRAN DI SUNGAI BEDOG, YOGYAKARTA BERDASARKAN KEANEKARAGAMAN PLANKTON
Authors: Fauzia Astri Zayanna , Suhartini Suhartini , Sudarsono Sudarsono
Published: June 2023

Sungai yang mengalir di Yogyakarta sangat banyak, salah satu sungai adalah Sungai Bedog. Di sekitar perairan tersebut terdapat beberapa jenis penggunaan lahan dan juga perubahan keadaan lingkungan sehingga dapat menurunkan kualitas air di Sungai Bedog, maka dari itu perlu dilakukan pengamatan tentang organisme yang terdapat di perairan tersebut, khusunya plankton. Penelitian ini bertujuan untuk mengetahui jenis plankton di Sungai Bedog, perbedaan jenis plankton di setiap stasiun penelitian, indeks keanekaragaman plankton di setiap stasiun dan kualitas perairan berdasarkan nilai indeks keanekaragaman plankton di Sungai Bedog. Penelitian ini merupakan penelitian deskriptif eksploratif yang dilakukan pada bulan Februari – April 2016. Lokasi pengambilan sampel berada pada 5 titik (stasiun) di sepanjang Sungai Bedog dari hulu hingga hilir sungai. Setelah pengambilan sampel lalu dilakukan pengamatan di laboratorium, penghitungan jumlah plankton dan penghitungan indeks keanekargaman menggunakan teori Shannon-Winner. Keadaan perubahan lingkungan yang terjadi mempengaruhi keadaan air sungai Bedog dan juga mempengaruhi keberlangsungan hidup plankton air. Ditandai dengan perubahan faktor fisik-kimia yang mempengaruhi pertumbuhan plankton dalam air. Keanekaragaman akan tinggi jika beberapa jenis organisme berkembang merata dan tidak terjadi dominansi yang tinggi. Indeks keanekaragaman Sungai Bedog yaitu 2,124 ind/L sehingga keadaan ini masuk dalam kategori sedang dan stabilias plankton di sepanjang sungai Bedog dalam kondisi sedang, sehingga perairan pada Sungai Bedog dalam kondisi tercemar sedang. Kata kunci : Plankton, Keanekaragaman, Sungai Bedog
PENGARUH PEMBERIAN TEPUNG IKAN GABUS (Channa striata) DALAM PAKAN KOMERSIL TERHADAP KELANGSUNGAN HIDUP DAN JUMLAH SEL DARAH MERAH IKAN LELE (Clarias Sp)
Authors: Retta Helda Ayuana , Harjana Tri , Suhandoyo Suhandoyo
Published: June 2023

Penelitian ini bertujuan untuk mengetahui pengaruh tepung ikan gabus  (Channa striata) dalam pakan komersil terhadap kelangsungan hidup dan jumlah sel darah merah ikan lele (Clarias sp).Penelitian ini merupakan penelitian eksperimen yang dilaksanakan dengan rancangan satu faktor pola acak lengkap (RAL). Faktor yang digunakan dalam penelitian ini adalah penambahan tepung ikan gabus yaitu pelet dengan tepung ikan gabus 2gr/100gr pelet, 4gr/100gr  pelet, 6gr/100gr pelet dan 8gr/100gr pelet dan menggunakan 1 pakan kontrol berupa pakan komersil ikan pf-1000. Setiap unit perlakuan berisi 30 ekor benih ikan lele dengan pengulangan sebanyak 3 kali. Parameter yang diukur adalah presentase kelangsungan hidup dan jumlah sel darah merah benih ikan lele. Data hasil penelitian dianalisis dengan menggunakan analisis Kruskal Wallis untuk melihat perbedaan kelompok perlakuan dengan kontrol.Hasil penelitian menunjukan pemberian tepung ikan gabus dalam pakan komersil berpengaruh terhadap kelangsungan hidup dan jumlah sel darah merah  ikan lele (P0,05). Kata Kunci : Ikan Lele (Clarias sp), Jumlah Sel Darah Merah, Kelangsungan, Tepung Ikan Gabus (Channa striata)
PENGARUH PEMBERIAN SENYAWA KROMIUM (III) NITRAT DAN KROMIUM (III) KLORIDA TERHADAP GAMBARAN HISTOLOGIK GINJAL PADA TIKUS PUTIH (Rattus novergicus) GALUR WISTAR YANG DIINDUKSI DENGAN STREPTOZOTOCIN-NICOTINAMIDE
Authors: Iriawan Renadi , Harjana Tri , Rahayu Tutiek
Published: June 2023

Penelitian ini bertujuan untuk mengetahui pengaruh pemberian senyawa kromium (III) nitrat dan kromium (III) klorida terhadap nekrosis sel ginjal tikus putih jantan galur Wistar yang diinduksi streptozotocin-nicotinamide. Jenis penelitian ini merupakan penelitian eksperimental dengan rancangan acak lengkap (RAL). Penelitian ini dilaksanakan selama 4 bulan. Tikus tersebut dibagi menjadi 4 kelompok perlakuan yaitu P1 (kromium nitrat), P2 (kromium klorida), K+ (kromium pikolinat) dan K- (Na-CMC). Variabel tergayutnya berupa persentase nekrosis sel ginjal tikus putih jantan galur Wistar. Metode pengumpulan data dengan melakukan pengamatan nekrosis sel ginjal menggunakan mikroskop cahaya. Data yang diperoleh dianalisis secara deskriptif, dan diuji one way anova. Hasil penelitian menunjukkan bahwa tikus yang diberi perlakuan memberikan pengaruh nyata (p0,05) dalam menurunkan nekrosis sel pada tahap karioreksis, serta memberikan pengaruh tidak nyata (p0,05) terhadap nekrosis sel pada tahap piknotis dan kariolisis untuk semua kelompok perbandingan. Kata kunci: kromium klorida, kromium nitrat, nekrosis sel, tikus putih.
PENGARUH VARIASI JENIS PUPUK TERHADAP KEANEKARAGAMAN DAN DINAMIKA POPULASI ARTROPODA PERMUKAAN TANAH (EPIFAUNA) PADA LAHAN PERTANIAN TANAMAN TOMAT (Lycopersicum esculentum)
Authors: Arifta Yoyon , Aminatun Tien , Susetya Nugroho
Published: June 2023

Penelitian ini bertujuan untuk mengetahui pengaruh variasi jenis pupuk terhadap keanekaragaman  dan dinamika populasi Artropoda permukaan tanah (epifauna) pada lahan pertanian tanaman tomat (Lycopersicum esculentum). Pengambilan data menggunakan metode pitfall trap selama 5 kali pengamatan. Artropoda yang tertangkap diidentifikasi hingga tingkat genus. Data yang dihitung dengan indeks keanekaragaman, indeks similaritas, dan pertumbuhan populasinya. Data dianalisis dengan uji One Way Annova dan uji regresi linier untuk faktor edafik. Hasil menunjukkan komposisi jenis Artropoda terdiri dari 23 genus dan 18 famili. Artropoda yang mendominasi adalah Plagiolepis (Formicidae)  dan Entomobrya (Collembola). Nilai Indeks Keanekaragaman Shanoon-wiener tertinggi adalah pupuk kandang (PK) yaitu 1,47 sedangkan secara keseluruhan  termasuk kategori sedang. Analisis regresi linier menunjukan faktor edafik tidak berpengaruh nyata. Dinamika populasi dipengaruhi oleh mekanisme bottom up, mekanisme top down, dan kesamaan jenis. Hasil uji One Way Anova menunjukkan bahwa dari jenis pupuk yang diberikan tidak memberikan pengaruh yang signifikan terhadap keanekaragaman dan Dinamika populasi Artropoda tanah (epifauna). Kata kunci: Artropoda, dinamika, epifauna, keanekaragaman,populasi, pupuk
PENGARUH LUMUT (Bryophyta) SEBAGAI KOMPOSISI MEDIA PERTUNASAN DAN PERTUMBUHAN TANAMAN BINAHONG (Anredera cordifolia)
Authors: Ipaulle Addinunnisa Auliya , Suryadarma IGP , Djukri Djukri
Published: June 2023

Penelitian ini bertujuan untuk (1) Mengetahui persentase terbaik bagi pertunasan tanaman binahong dengan komposisi lumut sebagai media. (2) Mengetahui pengaruh komposisi lumut sebagai media pertumbuhan tanaman binahong. (3) Mengetahui komposisi lumut yang optimal sebagai media yang memberikan pengaruh terbaik untuk pertumbuhan tanaman binahong. Penelitian ini disusun menggunakan Rancangan Acak Lengkap (RAL) satu faktor dengan perlakuan 5 jenis media tanam yang memiliki komposisi lumut berbeda yaitu R1.A (Kontrol, 0g lumut/900g tanah), R1.B (5%, 15g lumut/900g media), R1.C (10%, 30g lumut/900g media), R1.D (15%, 45g lumut/900g media) dan R1.E (20%, 60g lumut/900g media). Komposisi media terdiri dari lumut, tanah, pupuk kandang dan arang sekam. Terdapat 180 stek batang (3 stek x 6 ulangan x 5 perlakuan x 2) dalam 60 polybag, 30 polybag untuk panen yang dilakukan setiap 2 minggu sekali dan 30 polybag untuk diamati sampai 12 MST (Minggu Setelah Tanam). Hasil penelitian menunjukkan bahwa komposisi lumut dalam media berpengaruh nyata (p0,05) terhadap tinggi tanaman, jumlah daun, bobot basah dan bobot kering namun tidak berpengaruh nyata (p0,05) terhadap panjang akar pada pertumbuhan tanaman binahong. Komposisi lumut yang optimal untuk pertunasan dan tinggi tanaman binahong adalah R1.C (10%, 30g lumut/900g media), untuk jumlah daun tanaman binahong adalah R1.D (15%, 45g lumut/900g media) dan media R1.E (20%, 60g lumut/900g media) untuk panjang akar,  bobot basah serta bobot kering tanaman binahong.Kata kunci: Lumut, media tanam, pertunasan, pertumbuhan, tanaman binahong
STRUKTUR KOMUNITAS PLANKTON DI PERAIRAN WADUK WADASLINTANG KABUPATEN WONOSOBO
Authors: Wirabumi Putu , Sudarsono Sudarsono , Suhartini Suhartini
Published: June 2023

Penelitian ini bertujuan mengetahui kondisi lingkungan perairan berdasarkan parameter fisika kimia dan struktur komunitas plankton. Jenis penelitian adalah deskriptif dengan metode observasi. Pengambilan sampel dilakukan secara purposive sampling. Data yang diperoleh dianalisis secara deskriptif. Hasil penelitian menunjukkan kondisi lingkungan perairan berdasarkan parameter fisika kimia berada pada golongan baik dengan kriteria air tidak tercemar. Komposisi jenis plankton terdiri dari 38 jenis yang terbagi menjadi 5 kelas kelompok fitoplankton dan 3 kelas kelompok zooplankton. Indeks keanekaragaman per zona dan keseluruhan berada pada tingkat keanekaragaman rendah sampai sedang dengan ekosistem terganggu, indeks dominansi per zona dan keseluruhan berada pada tingkat dominansi rendah, indeks kemerataan per zona dan keseluruhan berada pada tingkat kemerataan cukup sampai kurang merata dengan komunitas tertekan,  indeks kesamaan per zona berada pada tingkat kesamaan sangat rendah sampai tinggi, dan indeks kekayaan per zona berada pada tingkat kekayaan rendah, namun secara keseluruhan berada pada tingkat kekayaan tinggi.Kata kunci: Struktur komunitas, Plankton, Waduk Wadaslintang.
PENGARUH PEMBERIAN VARIASI KADAR AIR KULIT JERUK NIPIS (Citrus aurantifolia) SEBAGAI PESTISIDA NABATI PENGENDALIAN HAMA Plutella xylostella PADA TANAMAN SAWI (Brassica juncea)
Authors: Situmorang Julita , Djukri Djukri
Published: June 2023

AbstrakPenelitian ini bertujuan untuk mengetahui pengaruh pemberian air kulit jeruk nipis (Citrusaurantifolia) terhadap kerusakan morfologi tanaman sawi, dosis optimal air kulit jeruk nipis (Citrusaurantifolia) sebagai pestisida nabati pengendali hama Plutella xylostella pada tanaman sawi(Brassica juncea), presentase mortalitas hama Plutella xylostella dan presentase jumlah pupa hamaPlutella xylostella. Jenis penelitian ini adalah Eksperimen Pola Rancangan Acak Lengkap (RAL)dengan 5 perlakuan variasi kadar air kulit jeruk nipis dengan 3 ulangan. Konsentrasi kadar Air kulitjeruk nipis yaitu 0%, 5%, 10%, 15% dan 20%. Hasil uji statistik menunjukkan (p0,05) bahwa adaperbedaan yang signifikan air kulit jeruk nipis mengakibatkan mortalitas hama Plutella xylostella. Airkulit jeruk nipis (Citrus aurantifolia) menyebabkan kematian hama Plutella xylostella paling efektifpada kadar 20%. Hasil uji statistik menunjukkan tidak terdapat perbedaan rata-rata presentaseterjadinya pembentukan pupa hama Plutella xylostella. Penyemprotan air kulit jeruk nipis padatanaman sawi tidak mengakibatkan kerusakan morfologi tanaman sawi.Kata kunci : hama Plutella xylostella, kulit jeruk nipis, pestisida Nabati
KUALITAS PERAIRAN DI TELAGA SARANGAN MAGETAN JAWA TIMUR BERDASARKAN INDEKS KEANEKARAGAMAN PLANKTON
Authors: Darwanti Esa Chorik , Sudarsono Sudarsono
Published: June 2023

Penelitian ini bertujuan untuk mengetahui indeks keanekaragaman plankton dan mengetahui kualitasperairan berdasarkan indeks keanekaragaman plankton di Telaga Sarangan, Kabupaten Magetan, Jawa Timur.Metode penelitian ini purposive sampling, pengambilan sampel pada lima stasiun menggunakan plankton net sertauji sifat fisika dan kimia air. Sampel diidentifikasi dan dianalisis dengan menghitung nilai densitas, nilai indekskeanekaragaman Shanon-Wienner, indeks kemerataan dan indeks dominansi. Hasil penelitian teridentifikasi 61jenis 11 kelas plankton terbagi kedalam 11 kelas. Komposisi jenis plankton tertinggi stasiun I (32 ind/L).Kelimpahan plankton (11.597 ind/L ) sehingga dikategorikan mesotrofik dan didominasi kelas Bacillarophyceae.Nilai indeks keanekaragaman plankton berkisar antara 2,8899-3,0285 ind/L, yang berarti kualitas perairantercemar ringan. Nilai indeks kemerataan relatif sedang berkisar antara 0,7030-0,7363 ind/L yang menunjukkanpenyebaran merata.dan nilai indeks dominansi 0,1081-0,2777.Kata kunci : plankton, kualitas perairan, keanekaragaman, Telaga Sarangan
UJI EFEKTIVITAS EKSTRAK BUAH MENTIMUN (Cucumis sativus L.) TERHADAP MORTALITAS LARVA Anopheles aconitus
Authors: Nurhidayat Irfan Azis , Sukiya Sukiya
Published: June 2023

Tujuan penelitian ini adalah: (1) mengetahui pengaruh ekstrak buah mentimun (Cucumis sativus L.)terhadap mortalitas larva nyamuk Anopheles aconitus, (2) mengetahui konsentrasi efektif ekstrak buahmentimun terhadap mortalitas larva nyamuk Anopheles aconitus, dan (3) mengetahui nilai LC50 24 jamekstrak buah mentimun terhadap mortalitas larva nyamuk Anopheles aconitus. Penelitian ini merupakaneksperimental laboratorium dengan desain post test only controlled group design. Ekstrak buah mentimundibuat dengan metode maserasi. Objek penelitian ini adalah larva nyamuk Anopheles aconitus instar III danIV dari B2P2VRP Salatiga umur 6-9 hari yang hidup dan bergerak aktif. Analisis data menggunakan probitLC50 24, Kruskal-Wallis, dan uji lanjut Mann-Whitney. Hasil penelitian menunjukan perlakuan konsentrasi0,01% (p0,05) paling berpengaruh terhadap peningkatan mortalitas larva Anopheles aconitus instar III danIV. Hasil analisis probit LC50 24 jam uji definitif adalah 0,009%. Konsentrasi efektif terhadap mortalitas 90%larva adalah 0,01-0,011%. Konsentrasi efektif terhadap mortalitas 100% larva adalah 0,1%.Kata Kunci : ekstrak buah mentimun, larva nyamuk Anopheles aconitus instar III dan IV, mortalitas larva, LC50 24 jam.