bluuebunny/crossref_metadata_2025 huggingface dataset:
Perturbation solutions of the diffusive chemo-mechanical coupling problem without a failure of local Fick’s law
Authors: Shen Xiaoyong , Wan Yongping
Published: December 2019

Silicon electrodes of lithium-ion batteries have a remarkable diffusive chemo-mechanical coupling effect during lithiation and delithiation. In order to study the variation of stresses and concentration distribution in the electrode, a nonlinear partial differential equation for the concentration is usually derived using the thermal analogy method and Fick’s laws, in the case without a failure of local Fick’s law. However, due to the nonlinearity of the equation and the boundary conditions, it is generally difficult to get the analytic solution. In this paper, by using the dimensionless quantities, the perturbation solutions are obtained for two fundamental problems, that is, the semi-infinite and the cylinder, which appears to be semi-analytic and easy for the numerical calculation. The results match with the numerical solutions very well, when the charge current density is controlled in a relatively appropriate range. The semi-analytic solutions show that the compressive stress promotes the diffusion of lithium in the electrode during lithiation, which cannot be neglected, compared with the condition without considering the coupling effect.
Techniques of Cryopreservation for Ovarian Tissue and Whole Ovary
Authors: Arav Amir , Patrizio Pasquale
Published: December 2019

Cryopreservation of ovarian tissue has been considered experimental for many years, but very recently the American Society of Reproductive Medicine is reviewing the process and perhaps soon will remove the label of “experimental” and recognize it as an established method for preserving female fertility when gonadotoxic treatments cannot be delayed or in patients before puberty or when there is desire to cryopreserve more than just few oocytes. This article discusses in detail the 3 methodologies used for cryopreservation: (a) slow freezing, (b) directional freezing, and (c) vitrification.
The binge-watcher’s journey: Investigating motivations, contexts, and affective states surrounding Netflix viewing
Authors: Castro Deborah , Rigby Jacob M , Cabral Diogo , Nisi Valentina
Published: December 2019

The growth of Internet-distributed TV services has transformed video consumption, enhancing the level of control that viewers have over what they watch. Along with the release of entire seasons of programming at once, this has led to the phenomenon of ‘binge-watching’, in which several episodes of a program are viewed in one sitting. This article presents the results of a novel exploratory study focused on 40 Netflix viewing sessions from 11 millennials in their homes. Methodologically, we employed a novel mixed-methods approach that combines objective data (collected through a browser extension) and subjective data (collected via questionnaires completed before and after viewing). This novel approach allowed us to describe the binge-watcher’s experience in a holistic fashion. Results suggest that binge-watching is an individual activity mainly performed at the end of the day to relax, for boredom relief purposes, or for escapism. Furthermore, a binge-watching session lasts for an average of 2 h and 10 min, and variations on binge-watchers’ affective states were identified after Netflix exposure. Participants’ levels of valence (unhappy–happy) significantly decreased after binge-watching; their positive affect values increased primarily after watching sci-fi, while their negative affect values decreased after watching comedy and slightly increased after watching drama. However, the levels of arousal (relaxed–stimulated) remained the same. This study extends our current understanding of binge-watching in terms of viewer motivations, how it affects their viewing experiences, and participants’ subjective affective states. The investigation contributes, thus, to a relatively new domain of research concerned with the understanding of binge-watching behavior of serialized TV fiction.
Metaphors and cultural narratives on adaptive responses to severe adversity: A field study among the Indigenous Pitaguary community in Brazil
Authors: Meili Iara , Heim Eva , Pelosi Ana C , Maercker Andreas
Published: December 2019

The expressions resilience and posttraumatic growth represent metaphorical concepts that are typically found in Euro-American contexts. Metaphors of severe adversity or trauma and the expressions of overcoming it vary across cultures—a lacuna, which has not been given much attention in the literature so far. This study aimed to explore the metaphorical concepts that the Indigenous Pitaguary community in Brazil uses to talk about adaptive and positive responses to severe adversity and to relate them to their socio-cultural context. We carried out 14 semi-structured interviews during field research over a one-month period of fieldwork. The data were explored with systematic metaphor analysis. The core metaphors included images of battle, unity, spirituality, journeys, balance, time, sight, transformation, and development. These metaphors were related to context-specific cultural narratives that underlie the Pitaguary ontological perspective on collectivity, nature, and cosmology. The results suggest that metaphors and cultural narratives can reveal important aspects of a culture’s collective mindset. To have a contextualized understanding of expressive nuances is an essential asset to adapt interventions to specific cultures and promote culture-specific healing and recovery processes.
Experimental study and theoretical analysis of glulam-concrete composite beams connected with ductile shear connectors
Authors: Hong Wan , Jiang Yuchen , Fang Yong , Hu Xiamin
Published: December 2019

Ductile shear connectors are often applied in timber-concrete composite beams. The relative interface slip of such kind of composite beams will affect the mechanical performance of the composite beams and result in structural nonlinearity. Gamma method which adopts effective bending stiffness to reflect semi-rigid connection is recommended in Eurocode 5. The effective bending stiffness is irrelevant to external loads and calculation points of the composite beam. However, actual bending stiffness distribution along the beam is variable due to that shear connectors are subjected to different shear force. In order to verify the accuracy of gamma method, four-point bending tests of a total of three glulam-concrete composite beams with lag screw connectors and one pure glulam beam were conducted in this article. The failure mode, bearing capacity, and load–deflection relationship were investigated in the experiment. Meanwhile, push-out tests of composite beams were also conducted for determination of the force–displacement relationship of ductile shear connectors. Then, numerical simulation using beam-truss model was established for investigation on the mechanism of composite beams. Finally, theoretical analysis of composite beams considering the effect of interface slip was also presented. Comparing results from gamma method with the presented method, it is shown that both methods can calculate deflection at serviceability limit state with high precision. However, non-uniform distribution of actual bending stiffness cannot be reflected by gamma method.
Doing family: The reproduction of heterosexuality in accounts of parenthood
Authors: Kazyak Emily , Park Nicholas K.
Published: December 2019

The cultural and legal landscape in the United States has shifted towards increased recognition of LGBQ-parent families. This shift raises questions about the everyday experiences of LGBQ parents and whether the cultural and legal changes also manifest in diminished experiences of discrimination. Drawing on data from 74 interviews with LGBQ parents, we analyze their accounts of whether they are read as a parent by others in their daily interactions. Our findings reveal the ways in which heterosexuality is a key component of how membership to the category of ‘parent’ is produced in social interactions. Our findings also illustrate how assumptions about heterosexuality are both racialized and gendered. Our focus on accountability foregrounds power in everyday interactions and provides a lens through which to understand how inequality and disempowerment for LGBQ people can persist in American society despite cultural and legal changes.
Perceptions and needs regarding technologies in nursing homes: An exploratory study
Authors: Bourbonnais Anne , Rousseau Jacqueline , Lalonde Marie-Hélène , Meunier Jean , Lapierre Nolwenn , Gagnon Marie-Pierre
Published: December 2019

Two of the most salient problems in nursing homes are the responsive behaviours and falls of older people living with Alzheimer’s disease and related disorders. Intelligent videomonitoring and mobile applications are potential technologies that may help prevent and manage these problems. However, evidence for the needs for technologies in nursing homes is scarce. This study aimed to explore the perceptions and needs of care managers, and of formal and family caregivers in nursing homes regarding these potential technologies. With an exploratory qualitative design based on Rogers’ diffusion of innovation theory, individual interviews and a content analysis were conducted. Results show that the potential users of these technologies consider them relevant in nursing homes. The characteristics that would make these technologies useful in nursing homes are described. These results could be used to develop useful technologies to improve the quality of clinical practice in nursing homes.
How to make an omelette: A sensory experiment in team ethnography
Authors: Harris Anna , Wojcik Andrea , Allison Rachel Vaden
Published: December 2019

Sensory ethnographers deploy methods such as drawing, video and photography in order to examine the more ineffable and non-representational aspects of practices. Usually, these studies are conducted by individual researchers who deal only with their own material. What happens when a team of ethnographers explores questions of a sensory or non-representational nature? How do they share their findings not only with their audiences, but also with each other? Team ethnography is becoming increasingly common across the social sciences and humanities, yet to date there has been little attention paid to the important work of communicating findings within a group. To explore this further, we conducted a methodological ‘proof of concept’ study, observing and documenting people learning to make omelettes. We found that sensory methods have a role not only in studying practices but crucially, in also facilitating a form of immersion into the ethnographic practices and imaginations of others within the team. In the end, we suggest that experiments with sensory methods, such as through proof of concept methodological studies, are useful for thinking about how teams of social scientists work together, whether their research deals with sensory topics or not.
Endovascular Therapy for Nonischemic vs Ischemic Complicated Acute Type B Aortic Dissection
Authors: Eleshra Ahmed , Kölbel Tilo , Panuccio Giuseppe , Rohlffs Fiona , Debus E. Sebastian , Tsilimparis Nikolaos
Published: December 2019

Purpose: To report a single-center experience with thoracic endovascular aortic repair (TEVAR) for complicated acute type B aortic dissection (cATBAD) comparing patients with vs without end-organ ischemia. Materials and Methods: Between November 2010 and December 2017, 64 patients (mean age 64.8±12.5 years; 49 men) underwent TEVAR for cATBAD. Patients were grouped into 2 cohorts: nonischemic (39, 61%) patients with unrelenting pain, early progressive aortic dilatation, uncontrolled hypertension, or rupture, and ischemic (25, 39%) patients with visceral, renal, lower extremity, or spinal cord hypoperfusion. Results: Mean time from diagnosis to treatment was 7.5 days (range 1–32) in the nonischemic group vs 2.3 days (range 1–14) days in the ischemic group (p=0.007). Fourteen (56%) of 25 ischemic cATBAD patients had stents implanted in the renovascular branch vessels, while 4 (16%) patients had stents implanted in the iliac arteries. When branch vessel cannulation failed, fenestrations were made in the intimal flap to improve perfusion of the involved branch (n=5). In the nonischemic group, 3 arteries were stented owing to atherosclerotic stenosis. Technical success was achieved in 62 (97%) of 64 patients; despite stenting, 2 patients had low renal artery perfusion on final angiography. There were no statistically significant differences in early or late outcomes between the nonischemic vs ischemic cATBAD patients. Six (9%) patients died within 30 days: 2 (5%) in the nonischemic group vs 4 (16%) in the ischemic group. Major complications (1 stroke, 2 cases of paraplegia, 1 retrograde type A dissection, and 1 case of bowel ischemia) occurred only in the nonischemic group. The mean follow-up was 28 months. Late endoleaks were observed in 3 (8%) nonischemic patients and 1 (4%) ischemic patient. Reinterventions were required in 7 (18%) nonischemic patients and 4 (16%) ischemic patients. Conclusion: TEVAR is an effective and safe method of treating cATBAD. Early intervention in ischemic cATBAD may have played a significant role in the lack of significant difference between ischemic and nonischemic cATBAD outcomes. Direct visceral reperfusion through branch vessel stenting during TEVAR may be crucial in achieving good outcomes in ischemic cATBAD.
MiR-200b-3p Functions as an Oncogene by Targeting ABCA1 in Lung Adenocarcinoma
Authors: Liu Keqiang , Zhang Weiqiang , Tan Jian , Ma Jingbo , Zhao Jing
Published: December 2019

Objective:

The aim of this study was to investigate the microRNA-200b-3p expression in lung adenocarcinoma and the possible functional associations of microRNA-200b-3p with cell proliferation, migration, and invasion.

Methods:

Quantitative real-time polymerase chain reaction was used to detect the expression of microRNA-200b-3p in lung adenocarcinoma samples and in the human lung adenocarcinoma cell lines A549 and H1299. A549 and H1299 cells were transfected with either a microRNA-200b-3p mimic or a negative control microRNA or either an empty vector or an adenosine triphosphate-binding cassette transporter A-1 overexpression vector. A Cell Counting Kit-8 assay was employed to assess the ability of cell proliferation. Transwell assays and transwell-Matrigel invasion assay were, respectively, utilized to assess the capacity of migration and invasion in A549 and H1299 cells.

Results:

The results showed that microRNA-200b-3p expression was significantly upregulated in tumor tissues compared with that in adjacent normal tissues. Overexpression of microRNA-200b-3p promoted lung adenocarcinoma cell proliferation and metastasis. Furthermore, adenosine triphosphate-binding cassette transporter A-1 was a direct target of microRNA-200b-3p, and this binding was verified by luciferase reporter analysis. Overexpression of adenosine triphosphate-binding cassette transporter A-1 obviously suppressed lung adenocarcinoma cell proliferation, migration, and invasion. Lung adenocarcinoma cell phenotypes induced by microRNA-200b-3p overexpression could be partially remitted by the co-overexpression of microRNA-200b-3p and adenosine triphosphate-binding cassette transporter A-1.

Conclusion:

This study first identified that microRNA-200b-3p is upregulated in lung adenocarcinoma cells and associated with cell proliferation and metastasis. MicroRNA-200b-3p promoted lung adenocarcinoma cell proliferation and metastasis by suppressing adenosine triphosphate-binding cassette transporter A-1. MicroRNA-200b-3p may function as a novel molecular marker and therapeutic target for lung adenocarcinoma treatment.
Arrested Mobilities: Affective Encounters and Crime Scenes in the City
Authors: Young Alison
Published: December 2019

Drawing on insights from emergent thinking within mobility studies to focus on the banalities of everyday urban commuting, walking and other forms of unremarkable travel, this article considers everyday encounters that take place as we pass through the spaces of the city. Consideration of such mundane encounters is located within a framework attending to the interplay of affect, aesthetics, mobilities and materiality, both within the city as it is figured in literary or poetic representation and as a physical and geographical space. Focusing on the recent killing of a taxi driver in Melbourne, and on readings of Teju Cole’s novel Open City and Claudia Rankine’s poetry in Citizen, the article’s aims are two-fold. The first is a consideration of encounters in which movement through the city is arrested, halted, or brought to a standstill, whether temporarily or permanently, through racism, robbery or lethal violence, with the result that cities become agglomerations of spaces in which violence or insult has taken place – a patchwork of invisible crime scenes. Its second consideration is to propose that such arrested mobilities, and the crime scenes they engender, momentarily expose aspects of urban existence that could be called hauntological, revealing the usually obscured ghosts of the city.
Influence of rurality on the awareness of myocardial infarction symptoms in the US
Authors: Tran Phoebe , Tran Lam
Published: December 2019

Background:

Myocardial infarctions (MIs) are the leading cause of death in the United States (US). Differences in MI mortality rates exist between rural and urban areas in the US. Early recognition of MI symptoms can lead to receiving prompt lifesaving treatment. In this study, we identified the influence of living in a rural area, rurality, on disparities in MI symptom awareness across the US.

Methods:

We examined 2007 and 2009 Behavioral Risk Factor Surveillances System survey data using logistic regressions to model the impact of rurality on MI symptom awareness while controlling for sociodemographic and MI clinical factors. From the results of these models, we created a type of marginal probability, known as average adjusted predictions (AAPs) and the difference in AAPs, called average marginal effects (AMEs), to determine patterns of awareness for each MI symptom between rural, suburban, and urban areas.

Results:

We found that there were similar odds and probabilities of being aware of all five MI symptoms between rural, suburban, and urban areas, although rural residents consistently had a slightly higher odds and probability of being aware of all five MI symptoms compared with suburban and urban residents. Rural, suburban, and urban residents had the highest probability of being aware of chest pain/discomfort (95.5–96.1%) and the lowest probability of being aware of jaw/back/neck pain (68.6–72.0%). After adjustment, more than 25% of rural, suburban, and urban residents were found to be unaware that jaw/back/neck pain and feeling weak/light-headed/faint were symptoms of MI. AMEs were greatest for all areas for jaw/back/neck pain (−3.5% to −3.2%) and smallest for chest pain/discomfort (−0.6% to −0.2%).

Conclusions:

The study’s results highlight the need to increase awareness of the MI symptoms of jaw/back/neck pain and feeling weak/light-headed/faint to shorten hospital delay and time to treatment, especially for rural areas where cardiovascular disease mortality is high.
The Antecedents and Consequences of Value Co-Creation Behaviors in a Hotel Setting: A Two-Country Study
Authors: Roy Sanjit K. , Balaji M. S. , Soutar Geoffrey , Jiang Yangyang
Published: December 2019

This study examines the antecedents and consequences of value co-creation behavior in a hospitality context. An online questionnaire with samples of hotel patrons in the United States and Australia was used to obtain data and partial least square modeling was used in the analysis. The results suggest patron fairness perception enhances trust and identification with a hotel, which encourage engagement in the value co-creation behavior. Furthermore, this behavior enhances patron well-being and respect for the hotel. The study contributes to the literature by suggesting a value co-creation behavior model in the hospitality context and empirically examining the antecedents and consequences of this behavior. The results have important implications for managers designing service encounters that can encourage hotel patrons to engage in the value co-creation behavior.
Epidemiology of Anterior Cruciate Ligament Injury in Italian First Division Soccer Players
Authors: Grassi Alberto , Macchiarola Luca , Filippini Matteo , Lucidi Gian Andrea , Della Villa Francesco , Zaffagnini Stefano
Published: December 2019

Background:

The burden of anterior cruciate ligament (ACL) injury in professional soccer players is particularly relevant as it represents a potentially career-threatening injury.

Hypothesis:

Our hypotheses were that (1) injury incidence rate would be similar to that reported in the literature, (2) we would identify a uniform distribution of the injuries along the season, and (3) injury incidence rate would be similar in high-ranked and lower ranked teams, based on final placement in the league.

Study Design:

Descriptive epidemiological study.

Level of Evidence:

Level 4.

Methods:

Professional male soccer players participating in the Serie A championship league in 7 consecutive seasons (2011-2012 to 2017-2018) were screened to identify ACL injuries through the online football archive transfermarkt.com . Exposure in matches and training were calculated.

Results:

There were 84 ACL injuries found (mean player age, 25.3 ± 4.2 years). Overall, 25% of ACL injuries were reruptures (15%) or contralateral injuries (10%). ACL incidence rate was 0.4215 per 1000 hours of play during Serie A matches, 0.0305 per 1000 hours of training (rate ratio [RR], 13.8; 95% CI, 8.4-22.7; P < 0.0001), and 0.0618 per 1000 hours of total play. Injury distribution had a bimodal peak, with the highest number of events in October and March. Alternatively, training injuries peaked in June and July. A significantly higher incidence rate was found for the teams ranked from 1st to 4th place compared with those ranked 5th to 20th (0.1256 vs 0.0559 per 1000 hours of play; RR, 2.2; 95% CI, 1.4-3.6; P = 0.0003). A similar finding was found for injury incidence proportion (3.76% vs 1.64%; P = 0.0003).

Conclusion:

The overall incidence rate of ACL injuries in Italian Serie A was 0.062 per 1000 hours, with a 14-fold risk in matches compared with training. Relevantly, 25% were second injuries. Most injuries occurred in October and March, and an almost 2-fold incidence rate and incidence proportion were noted in those teams ranked in the first 4 positions of the championship league.

Clinical Relevance:

Knowing the precise epidemiology of ACL injury in one of the most competitive professional football championship leagues could help delineate fields of research aimed to investigate its risk factors.
The association between dietary intake, lifestyle and incident symptomatic peripheral arterial disease among individuals with diabetes mellitus: insights from the Malmö Diet and Cancer study
Authors: Lilja Erika , Bergwall Sara , Sonestedt Emily , Gottsäter Anders , Acosta Stefan
Published: December 2019

With the rising prevalence of both diabetes mellitus (DM) and peripheral arterial disease (PAD), the aim of this project was to examine the association between dietary intake and lifestyle on the risk of developing PAD among individuals with DM. The Malmö Diet and Cancer study was a prospective cohort study with baseline examinations carried out between 1991 and 1996 in Malmö, Sweden ( n = 30,446). Individuals with prevalent PAD and cardiovascular disease (prior stroke or myocardial infarction) were excluded from the study, resulting in a total study population of 1112 patients with prevalent DM. The diagnosis of incident PAD was validated and confirmed in 98% of patients. Of the 1112 individuals, 136 (12.2%) were diagnosed with PAD during a median follow up of 19.7 years (interquartile range 12.9–22.4). Kaplan–Meier analysis showed that men with DM more often developed incident PAD compared with women (cumulative incidences 15.5% and 8.9%, respectively, p = 0.012). In Cox multivariable regression analysis, smoking (hazard ratio of 1.96, 95% confidence interval of 1.28–3.00) was associated with increased risk of PAD, and there was a trend that a higher intake of fish and shellfish (hazard ratio per additional gram per week of 0.99, 95% confidence interval of 0.99–1.00; p = 0.051) was associated with a decreased risk of PAD. In conclusion, the present study demonstrated a trend towards a protective effect of higher intake of fish and shellfish upon incident symptomatic PAD among individuals with DM.
Investigating the Presence of Environmental Kuznets Curve Hypothesis in India and China: An Autoregressive Distributive Lag Approach
Authors: Rani Ritu , Kumar Naresh
Published: December 2019

The Environmental Kuznets Curve (EKC) hypothesis advocates a reversed U-shaped association between different pollutants and per capita income. EKC postulates that speedy growth certainly results in environmental degradation due to glut use of natural resources and emission of pollutants. The study used carbon dioxide (CO2) emissions, economic growth, energy consumption, and the annual growth rate of population to investigate the EKC hypothesis in India and China for the period of 1971–2013. Furthermore, to explore the long-run and short-run relationship among competing variables, the autoregressive distributed lag model (ARDL) is used. Granger causality test is used to investigate the long-run and short-run causality between variables under study. The results support the EKC hypothesis in India and China, in both long-run and short-run, and inverse U-shaped association is found between CO2 emission and economic growth. Unidirectional causality seen in both countries in terms of economic growth and CO2 emissions. In addition, the coefficient of economic growth in a short-run model provides the evidence that there has been a gradual decline in environmental degradation (downward sloping of EKC) and the quality of the environment is gradually improving in China. Based on the findings, the study suggests that environmental policymakers, especially in India, should seriously address the issue of CO2 emissions as it has a tendency to move faster in the coming years.
A systematic review of high-frequency transcranial magnetic stimulation on motor cortex areas as a migraine preventive treatment
Authors: Hulla Ryan , Liegey-Dougall Angela
Published: December 2019

Background:

The results of high-frequency repetitive transcranial magnetic stimulation (rTMS) over the dorsolateral prefrontal cortex for migraine have been inconsistent. However, high-frequency rTMS over the motor cortex is a treatment that may be effective in relieving symptoms of migraine with a low risk of side effects.

Methods:

A systematic review of high-frequency rTMS over the brain motor cortex areas in human participants was conducted to assess efficacy in treating migraine. Articles that were not looking at migraine patients, stimulation over the left motor cortex, or were not in English were excluded. Nine articles representing eight experiments using high-frequency rTMS over the motor cortex areas for migraine in human participants were extracted from the databases of PubMed, PsycINFO, MedLine, CINAHL, and BioMed Central.

Results:

Two-hundred and seven of 213 patients completed treatment throughout all the studies examined. High-frequency rTMS over the motor cortex areas for migraine improved migraine frequency in seven of eight studies. Two of the eight studies were randomized controlled trials at low risk for biases and found high-frequency rTMS over the motor cortex areas effective in improving migraine frequency and severity. Other details of treatment prescription and symptoms were also examined.

Conclusion:

High-frequency rTMS over the motor cortex areas for migraine demonstrated efficacy as a migraine treatment, had minimal side effects, and should be further investigated.
UV-Visible Photodetector Based on I-type Heterostructure of ZnO-QDs/Monolayer MoS2
Authors: Zhou Yong Heng , Zhang Zhi Bin , Xu Ping , Zhang Han , Wang Bing
Published: December 2019

Monolayer MoS2 has shown excellent photoresponse properties, but its promising applications in high-sensitivity photodetection suffer from the atomic-thickness-limited adsorption and band gap-limited spectral selectivity. Here we have carried out investigations on MoS2 monolayer-based photodetectors with and without decoration of ZnO quantum dots (ZnO-QDs) for comparison. Compared with monolayer MoS2 photodetectors, the monolayer ZnO-QDs/MoS2 hybrid device exhibits faster response speed (1.5 s and 1.1 s, respectively), extended broadband photoresponse range (deep UV-visible), and enhanced photoresponse in visible spectrum, such as higher responsivity over 0.084 A/W and larger detectivity of 1.05 × 1011 Jones, which results from considerable injection of carries from ZnO-QDs to MoS2 due to the formation of I-type heterostructure existing in the contact interface of them.
Fluid resuscitation in trauma: what are the best strategies and fluids?
Authors: Ramesh G. H. , Uma J. C. , Farhath Sheerin
Published: December 2019

Background

Traumatic injuries pose a global health problem and account for about 10% global burden of disease. Among injured patients, the major cause of potentially preventable death is uncontrolled post-traumatic hemorrhage.

Main body

This review discusses the role of prehospital trauma care in low-resource/remote settings, goals, principles and evolving strategies of fluid resuscitation, ideal resuscitation fluid, and post-resuscitation fluid management. Management of fluid resuscitation in few special groups is also discussed.

Conclusions

Prehospital trauma care systems reduce mortality in low-resource/remote settings. Delayed resuscitation seems a better option when transport time to definitive care is shorter whereas goal-directed resuscitation with low-volume crystalloid seems a better option if transport time is longer. Few general recommendations regarding the choice of fluid are provided. Adhering to evidence-based clinical practice guidelines and local modifications based on patient population, available resources, and expertise will improve patient outcomes.
Sleep related painful erection: an algorithm for evaluation and management
Authors: Abdessater Maher , Kanbar Anthony , Zugail Ahmed S. , Al hammadi Abdalla , Guillonneau Bertrand , Beley Sebastien
Published: December 2019

Background

Sleep related painful erection (SRPE) is a rare parasomnia consisting of nocturnal penile tumescence accompanied by pain that awakens the individual. Normal non-painful erections are experienced when awake. No penile anatomic abnormalities are present. No conclusive randomized clinical trial is present in the literature about the management of this rare condition. The aim of this article is to review the current knowledge about the management of SRPE and to suggest an algorithm to help physicians evaluate and manage SRPE.

Material and methods

A literature review was conducted through PubMed database using the terms: sleep, pain, painful, penile, and erection. The reference lists of the articles were also reviewed. The search returned 23 references that were published between 1987 and 2019. Results were presented in a descriptive manner.

Results

Treatment decision for now is based on reports of the treatment success, the sustainability of remission, the tolerability by the patients and the potential side effects of each medication. From data available in literature, Baclofen is the mostly used medication with a tolerable profile of adverse effects. Phosphodiesterase type 5 inhibitors are considered potential treatments and are already widely used and tolerated for other indications, but so far only 2 successful trials have been reported for SRPE. Cinitapride is very promising, but only one case was studied and no side effects were reported. Clozapine can be very dangerous although highly effective.

Conclusion

Based on the limited number of treatment trials and reported cases, the low level of evidence and the lack of randomized clinical trials, no treatment consensus for SRPE can be reached. We suggested a useful tool for clinicians: an algorithm for the management of SRPE to facilitate their access to the literature without exhaustive return to case reports and series upon each case faced.
Immune repertoire fingerprinting by principal component analysis reveals shared features in subject groups with common exposures
Authors: Sevy Alexander M. , Soto Cinque , Bombardi Robin G. , Meiler Jens , Crowe James E.
Published: December 2019

Background

Advances in next-generation sequencing (NGS) of antibody repertoires have led to an explosion in B cell receptor sequence data from donors with many different disease states. These data have the potential to detect patterns of immune response across populations. However, to this point it has been difficult to interpret such patterns of immune response between disease states in the absence of functional data. There is a need for a robust method that can be used to distinguish general patterns of immune responses at the antibody repertoire level.

Results

We developed a method for reducing the complexity of antibody repertoire datasets using principal component analysis (PCA) and refer to our method as “repertoire fingerprinting.” We reduce the high dimensional space of an antibody repertoire to just two principal components that explain the majority of variation in those repertoires. We show that repertoires from individuals with a common experience or disease state can be clustered by their repertoire fingerprints to identify common antibody responses.

Conclusions

Our repertoire fingerprinting method for distinguishing immune repertoires has implications for characterizing an individual disease state. Methods to distinguish disease states based on pattern recognition in the adaptive immune response could be used to develop biomarkers with diagnostic or prognostic utility in patient care. Extending our analysis to larger cohorts of patients in the future should permit us to define more precisely those characteristics of the immune response that result from natural infection or autoimmunity.
Goal attainment scaling as an outcome measure in rare disease trials: a conceptual proposal for validation
Authors: Gaasterland C. M. W. , van der Weide M. C. Jansen , Roes K. C. B. , van der Lee J. H.
Published: December 2019

Background

Goal Attainment Scaling (GAS) is an instrument that is intended to evaluate the effect of an intervention by assessing change in daily life activities on an individual basis. However, GAS has not been validated adequately in an RCT setting. In this paper we propose a conceptual validation plan of GAS in the setting of rare disease drug trials, and describe a hypothetical trial where GAS could be validated.

Methods

We have used theCOnsensus-based Standards for the selection of health Measurement INstruments(COSMIN) taxonomy to deduce which measurement properties of GAS can be evaluated, and how. As individual GAS scores cannot be interpreted outside the context of a RCT, the validation of GAS needs to be done on trial as well as on individual level.

Results

The procedure of GAS consists of three steps. For the step of goal selection (step 1) and definition of levels of attainment (step 2), face validity may be assessed by clinical experts. For the evaluation of the goal attainment (step 3), the inter and intra rater reliability can be evaluated on an individual level. Construct validity may be evaluated by comparison with change scores on other instruments measuring in the same domain as particular goals, if available, and by testing hypotheses about differences between groups. A difference in mean GAS scores between a group who received an efficacious intervention and a control group is an indication of well-chosen goals, and corroborates construct validity of GAS on trial level. Responsiveness of GAS cannot be evaluated due to the nature of the construct being assessed.

Conclusion

GAS may be useful as an instrument to assess functional change as an outcome measure in heterogeneous chronic rare diseases, but it can only be interpreted and validated when used in RCTs with blinded outcome assessment. This proposed theoretical validation plan can be used as a starting point to validate GAS in specific conditions.
Colonic hematoma after extracorporeal shock wave lithotripsy for pancreatic stones: a case report
Authors: Liu Yu , Hao Lu , Wang Teng , Li Zhao-Shen , Xu Zheng-Lei , Hu Liang-Hao
Published: December 2019

Background

Despite pancreatic extracorporeal shock wave lithotripsy (P-ESWL) is a minimally invasive treatment for pancreatic stones, complications exist.

Case presentation

A 37-year-old male was diagnosed with chronic pancreatitis and admitted to our hospital for recurrent acute pancreatitis. After the first P-ESWL session, the patient complained of a new type of pain different from the previous pain pattern. Computerized tomography and colonoscopy were arranged and colonic hematoma was found. Since the patient had stable vital signs, no special treatment was given focusing on the colonic hematoma. Five days later, P-ESWL treatment was repeatedly performed for four consecutive days. Two days after the last P-ESWL session, the patient underwent endoscopic retrograde cholangiopancreatography. At the three-month follow up visit, the colonic hematoma disappeared and pancreatic stones decreased significantly.

Conclusions

To the best of our knowledge, colonic hematoma after P-ESWL for pancreatic stones has never been reported. Here, we present the only case of colonic hematoma after P-ESWL, which was coincidentally found in more than 6000 P-ESWL sessions in our hospital. As the symptoms of colonic hematoma are mild, we believe the incidence of colonic hematoma has been underestimated. Many people with colonic hematoma after P-ESWL may be undiagnosed or misdiagnosed. Treatment for colonic hematoma depends on whether there is severe clinical state. Exploration of more precise location method for pancreatic stones may reduce the probability of P-ESWL complication.
Association between anemia and frailty in 13,175 community-dwelling adults aged 50 years and older in China
Authors: Ruan Ye , Guo Yanfei , Kowal Paul , Lu Ye , Liu Chazhen , Sun Shuangyuan , Huang Zhezhou , Zheng Yang , Wang Wenjing , Li Gan , Shi Yan , Wu Fan
Published: December 2019

Background

Anemia and frailty contribute to poor health outcomes in older adults; however, most current research in lower income countries has concentrated on anemia or frailty alone rather than in combination. The aim of the present study was to investigate the association between anemia and frailty in community-dwelling adults aged 50 years and older in China.

Methods

The study population was sourced from the 2007/10 SAGE China Wave 1. Anemia was defined as hemoglobin less than 13 g/dL for men and less than 12 g/dL for women. A Frailty Index (FI) was compiled to assess frailty. The association between anemia and frailty was evaluated using a 2-level hierarchical logistic model.

Results

The prevalence of anemia was 31.0% (95%CI: 28.4, 33.8%) and frailty 14.7% (95%CI: 13.5, 16.0%). In the univariate regression model, presence of anemia was significantly associated with frailty (OR = 1.62, 95% CI: 1.39, 1.90) and the effect remained consistent after adjusting for various potential confounding factors including age, gender, residence, education, household wealth, fruit and vegetable intake, tobacco use, alcohol comsumption and physical activity (adjusted OR = 1.31, 95% CI:1.09, 1.57). Each 1 g/dL increase in hemoglobin concentration was associated with 4% decrease in the odds of frailty after adjusting for several confounding variables (adjusted OR = 0.96, 95% CI: 0.93, 0.99).

Conclusion

Anemia and low hemoglobin concentrations were significantly associated with frailty. Therefore, health care professionals caring for older adults should increase screening, assessment of causes and treatment of anemia as one method of avoiding, delaying or even reversing frailty.
Validation of the Iranian version of the childbirth experience questionnaire 2.0
Authors: Ghanbari-Homayi Solmaz , Dencker Anna , Fardiazar Zahra , Jafarabadi Mohammad Asghari , Mohammad-Alizadeh-Charandabi Sakineh , Meedya Shahla , Mohammadi Eesa , Mirghafourvand Mojgan
Published: December 2019

Background

Assessing women’s childbirth experiences is a crucial indicator in maternity services because negative childbirth experiences are associated with maternal mortalities and morbidities. Due to the high caesarean birth rate in Iran, measuring childbirth experience is a top priority, however, there is no standard tool to measure this key indicator in Iran. The aim of present study is to adapt the “Childbirth Experience Questionnaire 2.0” to the Iranian context and determine its psychometric characteristics.

Methods

Childbirth Experience Questionnaire 2.0 was translated into Farsi. A total of 500 primiparous women, at 4 to 16 weeks postpartum, were randomly selected from 54 healthcare centres in Tabriz. Internal consistency and reliability was calculated using the Cronbach’s Coefficient alpha and Intraclass Correlation Coefficient, respectively. Construct validity was assessed using exploratory and confirmatory factor analysis and discriminant validity using the known-group method and the Mann-Whitney U-test.

Results

The internal consistency and reliability for the total tool were high (Cronbach’s alpha = 0.93; Intraclass Correlation Coefficient = 0.97). Explanatory factor analysis demonstrated the adequacy of the sampling (Kaiser-Meyer-Olkin = 0.923) and significant factorable sphericity (p < 0.001). Confirmation factor analysis demonstrated acceptable values of fitness (RMSEA = 0.07, SRMSEA = 0.06, TLI = 0.97, CFI > 0.91, x2/ df = 4.23). Discriminatory validity of the tool was confirmed where the CEQ score and its subdomains were significantly higher in women who reported having control over their childbirth than women who did not.

Conclusion

The Farsi version of the Childbirth Experience Questionnaire 2.0 tool is a valid and reliable tool and can be used to measure the childbirth experience in Iranian women.
Maternal nutritional adequacy and gestational weight gain and their associations with birth outcomes among Vietnamese women
Authors: Tran Nga Thuy , Nguyen Lam Thi , Berde Yatin , Low Yen Ling , Tey Siew Ling , Huynh Dieu Thi Thu
Published: December 2019

Background

During pregnancy, a mother’s nutritional needs increase to meet the added nutrient demands for fetal growth and development. An enhanced understanding of adequate nutrition and sufficient weight gain during pregnancy can guide development of policies and strategies for maternal nutrition care, actions that will ultimately promote better pregnancy outcomes. In a sample of pregnant women in Vietnam, this study characterized maternal nutrition status and gestational weight gain at a mid-pregnancy baseline, then examined the association of these variables with specific birth outcomes.

Methods

The study used baseline data from a randomized, controlled trial that compared pregnant Vietnamese women who received a nutritional intervention group with those who received only standard dietary counseling (control group). At baseline (26–29 weeks gestation), mothers’ dietary reports were collected, and intake of 10 macro- and micronutrients was estimated; data for baseline gestational weight gain was collected for all pregnant women enrolled into the study (n = 228). This analysis also used weights, lengths, and head circumferences at birth for infants of mothers in the control group.

Results

At baseline, 95% of the pregnant women had concurrent inadequacies for more than five nutrients, and nearly half had concurrent inadequacies for more than ten nutrients. Almost two-thirds of the pregnant women did not meet recommendations for gestational weight gain. We found a significant, inverse association between the number of nutrient inadequacies and gestational weight gain (overallp ≤ 0.045). After adjusting for potential confounders, gestational weight gain was positively associated with birth weight, length at birth, birth weight-for-agez-score and length-for-agez-score (allp ≤ 0.006).

Conclusions

Our findings raise concern over the high proportion of pregnant women in Vietnam who have multiple concurrent nutrient inadequacies and who fall short of meeting recommended gestational weight gain standards. To ensure better birth outcomes in this population, policies and strategies to improve the status of maternal nutrition are greatly needed.

Trial registration

The trial was retrospectively registered at clinicaltrials.gov on December 20, 2013, registration identifier:NCT02016586.
Breast cancer risk status influences uptake, retention and efficacy of a weight loss programme amongst breast cancer screening attendees: two randomised controlled feasibility trials
Authors: Harvie Michelle , Pegington Mary , French David , Cooper Grace , McDiarmid Sarah , Howell Anthony , Donnelly Louise , Ruane Helen , Sellers Katharine , Foden Philip , Evans D. Gareth
Published: December 2019

Background

Excess body weight and sub-optimal lifestyle are modifiable causes of breast cancer and other diseases. There is little evidence that behaviour change is possible within screening programmes and whether this is influenced by prior knowledge of disease risk. We determined whether breast cancer risk influences uptake, retention and efficacy of a weight control programme in the UK National Health Service Breast Screening Programme, and whether additional cardiovascular disease and type 2 diabetes risk information improves uptake and retention further.

Method

Overweight/obese women in the UK National Health Service Breast Screening Programme identified at high, moderately increased, average and low-risk of breast cancer were randomised to receive individualised breast cancer risk information (breast cancer prevention programme), or individualised breast cancer, cardiovascular disease (QRISK2) and type 2 diabetes (QDiabetes, HbA1c) information (multiple disease prevention programme). Personalised breast cancer risk feedback was given before randomisation in Study-1, and after randomisation in Study-2.

Results

Recruitment was 9% (126/1356) in Study-1 and 7% (52/738) in Study-2. With respect to breast cancer risk, odds ratio of uptake for high/moderately increased vs low risk women was 1.99 (95% CI 1.24–3.17, P = 0.004) in Study-1 and 3.58 (95% CI 1.59–8.07, P = 0.002) in Study-2. Odds ratio of retention for high/moderately increased -risk vs. low risk women was 2.98 (95% CI 1.05–8.47, P = 0.041) in Study-1 and 3.88 (95% CI 1.07–14.04, P = 0.039) in Study-2. Weight loss of ≥5% at 12 months was achieved by 63% high/moderate vs. 43% low-risk women in Study-1 (P = 0.083) and 39% vs. 8% in Study-2 (P = 0.008). Uptake, retention and weight loss were equivalent in both the breast cancer prevention programme and the multiple disease prevention programme in both studies.

Conclusions

Women who are informed that they are at increased breast cancer risk were significantly more likely to join and remain in the programmes and consequently lose more weight across both studies. High risk women are more likely engage in a lifetyle prevention programme and also have the greatest potential benefit fom risk reduction strategies.

Trial registration

ISRCTN91372184 Registered 28 September 2014.