bluuebunny/crossref_metadata_2025 huggingface dataset:
BlockMatch: A Fine-Grained Binary Code Similarity Detection Approach Using Contrastive Learning for Basic Block Matching
Authors: Luo Zhenhao , Wang Pengfei , Xie Wei , Zhou Xu , Wang Baosheng
Published: November 2023

Binary code similarity detection (BCSD) plays a vital role in computer security and software engineering. Traditional BCSD methods heavily rely on specific features and necessitate rich expert knowledge, which are sensitive to code alterations. To improve the robustness against minor code alterations, recent research has shifted towards machine learning-based approaches. However, existing BCSD approaches mainly focus on function-level matching and face challenges related to large batch optimization and high quality sample selection at the basic block level. To overcome these challenges, we propose BlockMatch, a novel fine-grained BCSD approach that leverages natural language processing (NLP) techniques and contrastive learning for basic block matching. We treat instructions of basic blocks as a language and utilize a DeBERTa model to capture relative position relations and contextual semantics for encoding instruction sequences. For various operands in binary code, we propose a root operand model pre-training task to mitigate semantic missing of unseen operands. We then employ a mean pooling layer to generate basic block embeddings for detecting binary code similarity. Additionally, we propose a contrastive training framework, including a block augmentation model to generate high-quality training samples, improving the effectiveness of model training. Inspired by contrastive learning, we adopt the NT-Xent loss as our objective function, which allows larger sample sizes for model training and mitigates the convergence issues caused by limited local positive/negative samples. By conducting extensive experiments, we evaluate BlockMatch and compare it against state-of-the-art approaches such as PalmTree and SAFE. The results demonstrate that BlockMatch achieves a recall@1 of 0.912 at the basic block level under the cross-compiler scenario (pool size = 10), which outperforms PalmTree (0.810) and SAFE (0.798). Furthermore, our ablation study shows that the proposed contrastive training framework and root operand model pre-training task help our model achieve superior performance.
Infectious Diseases Associated with Exposure to Pollutants in a Local Population from Mexico
Authors: Mauricio-Gutiérrez Amparo , Romero-Arenas Omar , Tamariz-Flores Jose V. , Mora Ravelo Sandra Grisell , Cedillo Ramírez Lilia , Yañez Santos Jorge A. , Baéz Simón Alfredo
Published: November 2023

Agriculture is one of the primary activities in the municipality of Acatzingo, Puebla, Mexico. Agricultural fields are affected by the indiscriminate use of pesticides and hydrocarbon spills, which expose inhabitants to the development of infectious diseases. In the present study, we assessed the likelihood of developing infectious diseases associated with environmental contamination (pesticides and hydrocarbons) in various areas of the municipality of Acatzingo, Puebla, Mexico. A questionnaire was applied to 425 people in four areas of two locations divided according to exposure to hydrocarbons and pesticides. We conducted a binomial analysis using a binary logistic regression model, and the odds ratio (OR) was calculated at p ≤ 0.05. The development of infectious diseases is significantly associated with the geographical zone (p = 0.001). The population of Acatzingo de Hidalgo had a higher predicted probability (54.8%) of developing infections. Zone 3, which is exposed to hydrocarbons, had twice the probability of contracting infections (OR = 1.833, p = 0.093). Factors such as tobacco or alcohol consumption, gender, and age did not influence the development of infectious diseases. However, minors, businesspeople, and individuals with chronic degenerative diseases were more likely to contract infectious diseases. Therefore, it is crucial to implement control and regulation in managing pesticides and hydrocarbon spills to mitigate environmental contamination and the associated risks to human health.
Processes and Challenges for the Manufacturing of Lyocell Fibres with Alternative Agricultural Feedstocks
Authors: Lawson Lelia , Ford Madison , Hoque Md. Saiful , Chute Wade , Bressler David C. , Dolez Patricia I.
Published: November 2023

Lyocell man-made cellulosic fibres (L-MMCF) have been commercially available since the mid-1990’s, with the typical feedstock prepared from tree pulp or cotton linters. In recent years, there have been advancements in the utilisation of high alpha-cellulose agricultural biomass for L-MMCF feedstock. Industrial hemp stalks offer a unique opportunity for L-MMCF since hemp is considered an environmentally conscious crop that can also help to bridge the gap in worldwide cellulose shortages; additionally, industrial hemp stalks are high in alpha-cellulose, making this an ideal feedstock for L-MMCF manufacturing. This review paper outlines the lyocell process in detail, including processes for preparation of feedstocks, pulp processing, removal of contaminants and nonessential plant components, pulp dissolution, dope preparation, and fibre spinning. Opportunities and challenges associated with the utilisation of industrial hemp stalks as an alternative feedstock are addressed through all steps of the manufacturing process. Incorporating alternative feedstock opens new perspectives for manufacturing sustainable L-MMCF.
Multicriteria Optimization of Lower Limb Exoskeleton Mechanism
Authors: Ibrayev Sayat , Ibrayeva Arman , Rakhmatulina Ayaulym , Ibrayeva Aizhan , Amanov Bekzat , Imanbayeva Nurbibi
Published: November 2023

Typical leg exoskeletons employ open-loop kinematic chains with motors placed directly on movable joints; while this design offers flexibility, it leads to increased costs and heightened control complexity due to the high number of degrees of freedom. The use of heavy servo-motors to handle torque in active joints results in complex and bulky designs, as highlighted in the existing literature. In this analytical study, we introduced a novel synthesis method with analytical solutions provided for synthesizing the lower-limb exoskeleton. Furthermore, we proposed a mathematical model of multicriteria optimization; as a result, we obtained several lower-limb exoskeleton mechanisms comprising only six links, well-suited to the human anatomical structure, exhibit superior trajectory accuracy, efficient force transmission, satisfactory step height, and having internal transfer segment of the foot.
Santa Ana Winds: Multifractal Measures and Singularity Spectrum
Authors: Serpa-Usta Yeraldin , López-Lambraño Alvaro Alberto , Fuentes Carlos , Flores Dora-Luz , González-Durán Mario , López-Ramos Alvaro
Published: November 2023

A multifractal analysis based on the time series of temperature, pressure, relative humidity, wind speed, and wind direction was performed for 16 weather stations located in the hydrographic basin of the Guadalupe River in Baja California, Mexico. Our analysis included a 38-year dataset from MERRA-2 database, we investigated the multifractal nature of daily time series data for climatic variables associated with the Santa Ana Winds. We employed the Multifractal Detrended Fluctuation Analysis (MFDFA) method to extract multifractal complexity parameters (α0, ∆α, and r). This was adequate to evaluate the multifractality of the time series that represented the conditions of the phenomenon’s occurrence. From the estimation of the generalized Hurst exponent (hq), it was possible to characterize the time series of the meteorological variables in terms of the characteristics of persistence, anti-persistence, or randomness. Finally, the values corresponding to the parameters and characteristics of the multifractal spectrum or singularities can be used as quantitative and qualitative indicators to describe the dynamics of meteorological processes during the occurrence of the Santa Ana winds in the Guadalupe basin.
Mechanical Properties and Microscopic Mechanism of Basic Oxygen Furnace (BOF) Slag-Treated Clay Subgrades
Authors: Mustafayeva Arailym , Bimykova Aidana , Olagunju Sakiru Olarewaju , Kim Jong , Satyanaga Alfrendo , Moon Sung-Woo
Published: November 2023

Civil engineering faces a substantial challenge when dealing with soft and compressible clayey soils. Conventional soil stabilization techniques involving ordinary Portland cement (OPC) result in notable CO2 emissions. This study explores the utilization of basic oxygen furnace (BOF) slag, a by-product of steel production, for strengthening kaolin clay. This research investigates the influence of BOF slag particle size, BOF slag content, and the use of activators such as lime and ground granulated blast-furnace slag (GGBFS) on the stabilization of kaolin clay. The strength development is assessed through unconfined compressive strength (UCS) test, bender element (BE) test, and scanning electron microscopy (SEM). The findings reveal that higher BOF content and extended curing periods enhance soil strength, and lime and GGBFS effectively augment the stabilizing properties of BOF slag. Stabilizing kaolin clay with a 30% BOF/GGBFS mixture in a 50/50 ratio with 1% lime and curing for 7 days yielded a compressive strength of 753 kPa, meeting the Federal Highway Administration’s requirement for lime-treated soil. These combined measures contribute to developing a more robust and stable material with enhanced geotechnical properties.
Seismic Performance Evaluation and Retrofit Strategy of Overhead Gas-Insulated Transmission Lines
Authors: Li Xiaoxuan , Xie Qiang , Wen Jiayi
Published: November 2023

The overhead gas-insulated transmission line (GIL) in ultra-high-voltage converter stations, distinct from traditional buried pipelines, demands a thorough investigation into its seismic behavior due to limitations in existing codes. A refined finite element model is established, considering internal structure, slip between various parts, and the relative displacement at the internal conductor joint. Seismic analysis reveals the vulnerability of the GIL at the corner of the pipeline height change, with two failure modes: housing strength failure and internal conductor displacement exceeding the limit. Furthermore, the acceleration amplification coefficient of the support generally exceeds 2.0. Two retrofit methods, namely increasing the fundamental frequency of all supports and fixing the connections between all supports and the housing, have been proposed. The results indicate the effectiveness of both methods in reducing the relative displacement. Fixing all the supports effectively reduces the stress, whereas the other one yields the opposite effect. The seismic performance of a GIL is determined not by the dynamic amplification of supports, but by the control of relative displacement between critical sections, specifically influenced by the angular deformation of the pipeline’s first-order translational vibration mode along the line direction. Seismic vulnerability analysis reveals a reduction of over 50% in the failure probability of the GIL after the retrofit compared to before the retrofit, with the PGA exceeding 0.4 g.
The Finnish Professional Housing Market Operators’ Attitudes towards Smartness—Bridging the Gap between Practitioners and Smart Building Experts
Authors: Borgentorp Eerika , Kaartinen Sami , Junnila Seppo
Published: November 2023

The real estate sector is undergoing a significant transformation. The global energy transition has greatly impacted the entire energy infrastructure, forcing the energy-consuming property sector to increase its operational efficiency. Today, the European Union (EU) enhances building smartness in real estate through regulation. However, the attitudes towards smartness in the financially significant housing market remain unclear. This study observed the attitudes and readiness of Finnish housing market operators toward smartness at the end of 2022. In total, 13 semi-structured interviews were held with housing market professionals. The analysis was further supported by categorizing the interviewees into novice practitioners and smart building experts. The research results implied that the attitudes towards smartness among novice practitioners, including real estate investors and owners, are still rather reserved compared to the control group (consisting of smart building experts). However, enhancing the attitude of real estate investors and owners is crucial to ensure a successful smart transition towards carbon neutrality in the built environment. The results of this study highlight the need for a standardized metric for building smartness. However, engaging market practitioners in developing such metrics is essential to ensure that the future standard for smartness answers the market’s needs.
Review of Current Treatment Intensification Strategies for Prostate Cancer Patients
Authors: Wasim Sobia , Park Jieun , Nam Seungyoon , Kim Jaehong
Published: November 2023

Prostate cancer (PCa) used to be one of the most common nondermatologic cancers in men that can be treated only with surgery. However, a revolutionary breakthrough came in the 1980s with the introduction of long-acting luteinizing hormone-releasing hormone (LHRH) agonists for the curative treatment of PCa. This paradigm shift contributed to the combined use of androgen deprivation therapy (ADT), chemotherapy, and radiotherapy for the treatment. The latest data highlight the use of treatment intensification (TI), i.e., combined use of radiotherapy (RT) and hormonal or drug treatments, for localized or locally advanced PCa. Indeed, the results of combined modality treatments have shown a reduction in disease-specific mortality and improved overall survival. Although TI seems promising, more research studies are warranted to confirm its efficacy. This review summarizes the latest available outcome results of pivotal trials and clinical studies on the efficacy of TI.
Spatial Distribution of Non-Immune Cells Expressing Glycoprotein A Repetitions Predominant in Human and Murine Metastatic Lymph Nodes
Authors: Rouaud Loïc , Baudin Louis , Gautier-Isola Marine , Van Meerbeeck Pierre , Feyereisen Emilie , Blacher Silvia , van Baren Nicolas , Kridelka Frédéric , Lucas Sophie , Noel Agnes
Published: November 2023

Several types of cancer spread through the lymphatic system via the sentinel lymph nodes (LNs). Such LN-draining primary tumors, modified by tumor factors, lead to the formation of a metastatic niche associated with an increased number of Foxp3+ regulatory T cells (Tregs). These cells are expected to contribute to the elaboration of an immune-suppressive environment. Activated Tregs express glycoprotein A repetitions predominant (GARP), which binds and presents latent transforming growth factor beta 1 (TGF-β1) at their surface. GARP is also expressed by other non-immune cell types poorly described in LNs. Here, we mapped GARP expression in non-immune cells in human and mouse metastatic LNs. The mining of available (human and murine) scRNA-Seq datasets revealed GARP expression by blood (BEC)/lymphatic (LEC) endothelial, fibroblastic, and perivascular cells. Consistently, through immunostaining and in situ RNA hybridization approaches, GARP was detected in and around blood and lymphatic vessels, in (αSMA+) fibroblasts, and in perivascular cells associated with an abundant matrix. Strikingly, GARP was detected in LECs forming the subcapsular sinus and high endothelial venules (HEVs), two vascular structures localized at the interface between LNs and the afferent lymphatic and blood vessels. Altogether, we here provide the first distribution maps for GARP in human and murine LNs.
Hormonal Contraception and the Risk of Breast Cancer in Women of Reproductive Age: A Meta-Analysis
Authors: Torres-de la Roche Luz Angela , Acevedo-Mesa Angélica , Lizarazo Ingrid Lizeth , Devassy Rajesh , Becker Sven , Krentel Harald , De Wilde Rudy Leon
Published: November 2023

This study aims to summarize evidence from observational studies about the lifetime use of HC and the risk of BC in women of reproductive age. The PubMed, Cochrane, and EMBASE databases were searched for observational studies published from 2015 to February 2022. Meta-analyses were performed using adjusted odds ratios and relative risks with a random-effects model using the I2 statistic to quantify the heterogeneity among studies. Of the 724 studies identified, 650 were screened for title/abstract selection, 60 were selected for full-text revision, and 22 were included in the meta-analysis. Of these, 19 were case-control studies and 3 were cohort studies. The results of the meta-analysis indicate a significantly higher risk of developing BC in ever users of HC (pooled OR = 1.33; 95% CI = 1.19 to 1.49). This effect is larger in the subgroups of case-control studies (pooled OR = 1.44, 95% CI = 1.21 to 1.70) and in the subgroup of studies that strictly define menopausal status (pooled OR = 1.48; 95% CI, 1.10 to 2.00). Although our meta-analysis of observational studies (cohort and case-control) suggests a significantly increased overall risk of BC in users or ever-users of modern hormonal contraceptives, the high heterogeneity among studies (>70%) related to differences in study design, measurement of variables, confounders, among other factors, as well as publication biases should be considered when interpreting our results.
The Role of ZNF275/AKT Pathway in Carcinogenesis and Cisplatin Chemosensitivity of Cervical Cancer Using Patient-Derived Xenograft Models
Authors: Ye Miaomiao , Liu Tingxian , Miao Liqing , Zou Shuangwei , Ji Huihui , Zhang Jian’an , Zhu Xueqiong
Published: November 2023

Zinc finger protein 275 (ZNF275) is a C2H2-type transcription factor that is localized on chromosome Xq28. Whether ZNF275 participates in modulating the biological behaviors of cervical cancer has not been determined to our knowledge. The present study employed CCK-8, BrdU, flow cytometry, and a transwell assay to investigate the cell viability, proliferation, apoptosis, migration, and invasion of cervical cancer cells. The application of Western blotting and immunohistochemistry (IHC) aims to assess ZNF275 protein expression and identify the signaling pathway relevant to ZNF275-mediated effects on cervical cancer. The therapeutic impact of the combined therapy of the AKT inhibitor triciribine and cisplatin was evaluated on cervical cancer patient-derived xenograft (PDX) models expressing high ZNF275. The current research illustrated that cervical cancer tissue exhibited a higher expression of ZNF275 in contrast to the surrounding normal cervical tissue. The downregulation of ZNF275 suppressed cell viability, migration, and invasion, and facilitated the apoptosis of SiHa and HeLa cells via weakening AKT/Bcl-2 signaling pathway. Moreover, triciribine synergized with cisplatin to reduce cell proliferation, migration, and invasion, and enhanced the apoptosis of SiHa cells expressing high ZNF275. In addition, the combination treatment of triciribine and cisplatin was more effective in inducing tumor regression than single agents in cervical cancer PDX models expressing high ZNF275. Collectively, the current findings demonstrated that ZNF275 serves as a sufficiently predictive indicator of the therapeutic effectiveness of the combined treatment of triciribine and cisplatin on cervical cancer. Combining triciribine with cisplatin greatly broadens the therapeutic options for cervical cancer expressing high ZNF275, but further research is needed to confirm these results.
Efficient Synthesis of Nickel-Molybdenum/USY-Zeolite Catalyst for Eliminating Impurities (N, S, and Cl) in the Waste Plastic Pyrolysis Oil: Dispersion Effect of Active Sites by Surfactant-Assisted Melt-Infiltration
Authors: Cho Eui Hyun , Kim Ki-Duk , Yoon Byung Sun , Cho Eunkyung , Yu Yeon Jeong , Phan Tuan Ngoc , Jeon Sang-Goo , Ko Chang Hyun
Published: November 2023

The upgrading of waste plastic pyrolysis oil (WPPO) through hydrotreating (HDT) is crucial for transforming plastic waste into chemical feedstock. The catalytic role of HDT is of paramount importance for this conversion procedure. In this study, bimetallic catalysts based on Ni and Mo were prepared using the surfactant-assisted melt-infiltration (SAMI) method, completely omitting the use of liquid solutions. Thorough analysis via X-ray diffraction, transmission electron microscopy, and hydrogen temperature-programmed reduction confirmed that the addition of Span60 surfactant effectively prevented the aggregation of Ni and Mo components, reduced the size of metal particles, and improved the dispersion of active sites on the zeolite supports. Consequently, NiMo-based catalysts incorporating Span60, synthesized using the SAMI method, exhibited a superior catalytic performance in the removal of nitrogen, sulfur, and chloride impurities from WPPO during HDT compared to those without surfactant. Specifically, the catalyst prepared with Span60 exhibited 15% higher nitrogen conversion compared to the catalyst prepared without Span60.
Heat-Transfer Analysis of the Promotion of the CO2 Reduction Performance of a P4O10/TiO2 Photocatalyst Using a Black Body Material
Authors: Nishimura Akira , Hanyu Ryo , Mae Homare , Senoue Hiroki , Hu Eric
Published: November 2023

Since photocatalytic reactions are surface reactions, enhancing gas movement around the photocatalyst could improve photocatalytic CO2 reduction performance. A new approach using black body material to enhance the gas movement around the photocatalyst based on the natural thermosiphon movement of gases around a photocatalyst has been proposed and confirmed experimentally, but the heat-transfer mechanism of the phenomena has not yet been clarified. The aim of this study is to clarify the corresponding heat-transfer mechanism. This study calculated the temperature of the CO2/NH3 gas mixture around a P4O10/TiO2 photocatalyst using the heat-transfer formula. No difference was found between the temperature increase (Tg) from the temperature at the beginning of the CO2 reduction experiment (Tini) and the temperature of the CO2/NH3 gas mixture measured experimentally via thermocouple (Te) under the following illumination conditions: a Xe lamp with visible light (VIS) + infrared light (IR) and IR only. The heat-transfer model proposed in this study predicts Tg well under illumination from a Xe lamp with VIS + IR as well as under IR illumination only. On the other hand, the difference found between Tg and Te was as large as 10 °C under illumination from a Xe lamp with ultraviolet light (UV) + VIS + IR.
Common Variants in Osteopontin and CD44 Genes as Predictors of Treatment Outcome in Radiotherapy and Chemoradiotherapy for Non-Small Cell Lung Cancer
Authors: Gałecki Seweryn , Gdowicz-Kłosok Agnieszka , Deja Regina , Masłyk Barbara , Giglok Monika , Suwiński Rafał , Butkiewicz Dorota
Published: November 2023

Osteopontin (OPN)-CD44 signaling plays an important role in promoting tumor progression and metastasis. In cancer, OPN and CD44 overexpression is a marker of aggressive disease and poor prognosis, and correlates with therapy resistance. In this study, we aimed to evaluate the association of single nucleotide polymorphisms (SNPs) in the OPN and CD44 genes with clinical outcomes in 307 non-small cell lung cancer (NSCLC) patients treated with radiotherapy or chemoradiotherapy. The potential impact of the variants on plasma OPN levels was also investigated. Multivariate analysis showed that OPN rs11730582 CC carriers had a significantly increased risk of death (p = 0.029), while the CD44 rs187116 A allele correlated with a reduced risk of locoregional recurrence (p = 0.016) in the curative treatment subset. The rs11730582/rs187116 combination was associated with an elevated risk of metastasis in these patients (p = 0.016). Furthermore, the OPN rs1126772 G variant alone (p = 0.018) and in combination with rs11730582 CC (p = 7 × 10−5) was associated with poor overall survival (OS) in the squamous cell carcinoma subgroup. The rs11730582 CC, rs187116 GG, and rs1126772 G, as well as their respective combinations, were independent risk factors for unfavorable treatment outcomes. The impact of rs11730582-rs1126772 haplotypes on OS was also observed. These data suggest that OPN and CD44 germline variants may predict treatment effects in NSCLC.
The Interleukin 6 Protein Level as well as a Genetic Variants, (rs1800795, rs1800797) Are Associated with Adverse Cardiovascular Outcomes within 10-Years Follow-Up
Authors: Schulz Susanne , Rehm Selina , Schlitt Axel , Bitter Kerstin , Reichert Stefan
Published: November 2023

Background: Worldwide, cardiovascular disease (CVD) is the leading cause of premature death. The proinflammatory cytokine interleukin 6 (IL-6) is a essential marker of innate immunity that is considered to play an important proatherogenic role for cardiovascular disease. The aim of this study (substudy of ClinTrials.gov identifier: NCT01045070) was to evaluate IL-6 protein level and genetic variants (rs1800795, rs1800797) with respect to CV outcome (combined endpoint: myocardial infarction, stroke/transient ischemic attack, cardiac death, death according to stroke) among patients CVD within 10-years follow-up. Material and methods: Overall 1002 in-patients with CVD were included. IL-6 protein level was determined by electrochemiluminescence immunoassay (fasting, between 7 and 8 a.m.). Genetic analyses were carried out by single specific primer-polymerase chain reaction. Results: In survival analyses, IL-6 protein levels of ≥6.4 pg/mL (log-rank test: p = 0.034; cox regression: p = 0.032, hazard ratio = 1.29) and CC genotype of rs1800795 (log-rank test: p < 0.001, cox regression: p < 0.001, hazard ratio = 1.72) and AA genotype of rs180797 (log-rank test: p = 0.002, cox regression: p < 0.001, hazard ratio = 1.62) were associated with a poorer CV prognosis considering combined CV endpoint. Conclusion: This study was the first to investigate both elevated IL-6 levels and genetic variants for their prognostic value for adverse CV outcomes in CVD patients within the 10-year follow-up period.
Integrated Process for High Phenol Removal from Wastewater Employing a ZnO Nanocatalyst in an Ozonation Reaction in a Packed Bubble Column Reactor
Authors: Majhool Adnan K. , Sukkar Khalid A. , Alsaffar May A. , Majdi Hasan Shakir
Published: November 2023

The use of an ozonized bubble column reactor (OBCR) in wastewater treatment is advantageous due to its efficient mixing and mass transfer characteristics. Among all high-performance features, the ozonation reaction in a BCR undergoes a low dissolution of O3 in the reactor with a limited reaction rate. In this study, the ozonation reaction of phenol in an OBCR was tested using a ZnO nanocatalyst and alumina balls as packing material. Three concentrations of O3 were evaluated (i.e., 10, 15, and 20 ppm), and 20 ppm was found to be the optimum concentration for phenol degradation. Also, two doses (i.e., 0.05 and 0.1 g/L) of ZnO nanocatalysts were applied in the reaction mixture, with the optimal dose found to be 0.1 g/L. Accordingly, three phenol concentrations were investigated in the OBCR (i.e., 15, 20, and 25 ppm) using four treatment methods (i.e., O3 alone, O3/Al2O3, O3/ZnO nanocatalyst, and O3/Al2O3/ZnO nanocatalyst). At a contact time of 60 min and phenol concentration of 15 ppm, the removal rate was 66.2, 73.1, 74.5, and 86.8% for each treatment method, respectively. The treatment experiment that applied the O3/Al2O3/ZnO nanocatalyst produced the highest phenol conversion into CO2 and H2O in the shortest contact time for all phenol concentrations. Thus, the OBCR employed with a ZnO nanocatalyst plus packing material is a promising technology for the rapid and active removal of phenol because it enhances the number of hydroxyl radicals (•OH) generated, which ultimately increases the oxidation activity in the OBCR. Also, the results showed efficient flow characteristics in the OBCR, with channeling problems averted due to appropriate gas movement resulting from the use of packing materials. Finally, it was found that the ozonation process in an OBCR is an efficient method for phenol conversion with good economic feasibility.
Review on Corrosion, Tribocorrosion and Osseointegration of Titanium Alloys as Biomaterials
Authors: Takadoum Jamal
Published: November 2023

When introduced into the body, the implant interacts with biological environment and may suffer corrosion. In addition, when this implant is submitted to friction, it may degrade by tribocorrosion due to the simultaneous action of corrosion by the body liquid and mechanical wear. Both corrosion and tribocorrosion are connected to the presence of proteins that cover the surface implant. The latter plays an ambiguous role on corrosion since dozens of contradictory papers pointed out their beneficial or detrimental effect. After its introduction into the body, the implant should form a direct interface with bone through structural and functional connection. The osseointegration and the strength of interfacial bond depend on surface properties of the implant, namely, its topographical and physico-chemical properties. In addition, since bone cells are sensitive to the species produced during the implant corrosion, when corrosion occurs, this may lead to impact osseointegration and to cause implant loosening. There is a strong connection between corrosion and osseointegration, both of which are worth discussion. That is the object of the present narrative review where we will discuss: (1) corrosion and tribocorrosion of titanium alloys used as biomaterials paying particular attention to the influence of proteins, (2) the effect of implant roughness and surface energy on osseointegration.
Design and Implement an Accurate Automated Static Analysis Checker to Detect Insecure Use of SecurityManager
Authors: Alqaradaghi Midya , Nazir Muhammad Zafar Iqbal , Kozsik Tamás
Published: November 2023

Static analysis is a software testing technique that analyzes the code without executing it. It is widely used to detect vulnerabilities, errors, and other issues during software development. Many tools are available for static analysis of Java code, including SpotBugs. Methods that perform a security check must be declared private or final; otherwise, they can be compromised when a malicious subclass overrides the methods and omits the checks. In Java, security checks can be performed using the SecurityManager class. This paper addresses the aforementioned problem by building a new automated checker that raises an issue when this rule is violated. The checker is built under the SpotBugs static analysis tool. We evaluated our approach on both custom test cases and real-world software, and the results revealed that the checker successfully detected related bugs in both with optimal metrics values.
Investigation of Preparation of Slag Wool from Melting-Separated Red Mud
Authors: Du Peipei , Zhang Yuzhu , Long Yue , Xing Lei
Published: November 2023

The preparation of high-quality inorganic fibers by centrifugation from modified melting-separated red mud, which is the product of the efficient recovery of pig iron from red mud, is a new approach to achieve large-scale production of high value-added materials from red mud. This method has a wide range of application prospects and could contribute substantially to the comprehensive utilization of bulk industrial solid waste and the development of a circular economy. In this study, melting-separated red mud was modified with water-quenched blast furnace slag, quartz sand, and quicklime. The effect of the CaO/Na2O mass ratio on the viscosity, fluidity, and crystallization performance of the melting-separated red mud was investigated; slag wool was prepared by centrifugation under laboratory conditions; and the effect of the CaO/Na2O mass ratio on the morphology and properties of the slag wool was investigated. The viscosity of modified melting-separated red mud with different CaO/Na2O mass ratios shows a decreasing trend with increasing temperature, and the fluidity increases with increasing temperature, indicating that the melt fluidity is improved. The suitable fiber-forming temperature of the melting-separated red mud shows a trend of increasing–decreasing–increasing with an increasing CaO/Na2O mass ratio, and at a CaO/Na2O ratio of 3.0, the maximum suitable fiber-forming temperature is 81 °C. Considering the feasibility of slag wool preparation from modified melting-separated red mud, the CaO/Na2O of the modified raw material system should not be higher than 3.0. The crystallization temperature of modified melting-separated red mud with different CaO/Na2O mass ratios first increases and then decreases, with a peak of 1450 °C at a CaO/Na2O ratio of 4.0. Slag wool prepared from modified melting-separated red mud with different CaO/Na2O mass ratios exhibits good properties, with a diameter of 5.47–6.67 µm and a slag ball content of 2.7–8.4%.
Rocking Devices and the Role of Vestibular Stimulation on Sleep—A Systematic Review
Authors: Subramaniam Abimanju , Eberhard-Moscicka Aleksandra K. , Ertl Matthias , Mast Fred W.
Published: November 2023

Rocking devices are widely used across different age groups to facilitate sleep. This review discusses the current literature on rocking devices and how passive vestibular stimulation influences sleep architecture, sleep oscillations, and cognitive performance. We included eight studies that conducted research with rocking devices in humans (7) and mice (1) during daytime naps and/or nighttime sleep, respectively. Overall, vestibular stimulation during sleep induced faster sleep onset, coupled with more N2 in daytime naps or N3 in nighttime sleep. Vestibular stimulation also led to more sleep spindles and better memory consolidation. Optimal stimulation intensity was around 25 cm/s2, and lower intensities led to smaller effects. The findings suggest a sweet spot for vestibular stimulation intensity, promoting deeper sleep at the cost of wakefulness or N1 sleep without compromising REM sleep. While further studies are needed to thoroughly investigate the motion parameters that drive the impact on sleep and cognitive performance, rocking devices may present a promising therapeutic tool for people with disrupted sleep patterns.
Aldehyde Dehydrogenase Diversity in Azospirillum Genomes
Authors: Cuatlayotl-Olarte Ricardo , Xiqui-Vázquez María Luisa , Reyes-Carmona Sandra Raquel , Mancilla-Simbro Claudia , Baca Beatriz Eugenia , Ramírez-Mata Alberto
Published: November 2023

Aldehyde dehydrogenases (ALDHs) are indispensable enzymes that play a pivotal role in mitigating aldehyde toxicity by converting them into less reactive compounds. Despite the availability of fully sequenced Azospirillum genomes in public databases, a comprehensive analysis of the ALDH superfamily within these genomes has yet to be undertaken. This study presents the identification and classification of 17 families and 31 subfamilies of ALDHs in fully assembled Azospirillum genomes. This classification system framework provides a more comprehensive understanding of the diversity and redundancy of ALDHs across bacterial genomes, which can aid in elucidating the distinct characteristics and functions of each family. The study also proposes the adoption of the ALDH19 family as a powerful phylogenetic marker due to its remarkable conservation and non-redundancy across various Azospirillum species. The diversity of ALDHs among different strains of Azospirillum can influence their adaptation and survival under various environmental conditions. The findings of this study could potentially be used to improve agricultural production by enhancing the growth and productivity of crops. Azospirillum bacteria establish a mutualistic relationship with plants and can promote plant growth by producing phytohormones such as indole-3-acetic acid (IAA). The diversity of ALDHs in Azospirillum can affect their ability to produce IAA and other beneficial compounds that promote plant growth and can be used as biofertilizers to enhance agricultural productivity.
Acinetobacter thutiue sp. nov. Isolated from Oil-Contaminated Soil in Motorbike Repair Workshops
Authors: Tuyet Nhan Le Thi , Kim Jaisoo
Published: November 2023

Two Acinetobacter isolates were found in soil samples from motorbike repair workshop floors in Vietnam. The two Acinetobacter isolates were Gram-stain-negative, coccobacilli-shaped, aerobic, non-motile, non-hemolytic, oxidase-negative, and catalase-positive. They were designated as strains VNH17T and VNK23. Their growth was inhibited by NaCl concentrations of >3%, and they grew at an optimal temperature of 20–35 °C. Acidification of D-glucose and hydrolysis of gelatin were negative. They grew on β-alanine, ethanol, L-histidine, D-malate, and L-ornithine whereas L-arginine, citrate, L-glutamate, and L-phenylalanine were not utilized. Core genome-based phylogenetic analysis revealed that the two isolated strains formed a lineage within the genus Acinetobacter in the family Moraxellaceae, the closest relative was Acinetobacter pavus (91.70–91.95%), and were grouped within a hemolytic clade with other closely-related relatives. The DNA G+C content of VNH17T and VNK23 was 42.07% and 41.75%, respectively. The average nucleotide identity and in silico DNA-DNA hybridization relatedness values (74.41–91.61% and 20.6–45.40%, respectively) between the Acinetobacter isolates and phylogenetically related type strains were below the threshold values used for species delineation. Based on genomic, chemotaxonomic, phenotypic, and phylogenomic analyses, the isolated strains represent novel species in the genus Acinetobacter, for which the name Acinetobacter thutiue sp. nov. (type strain VNH17T = KACC 23003T = CCTCC AB 2023063T) is proposed.
Assessment of Sudden Cardiac Death Risk in Pediatric Primary Electrical Disorders: A Comprehensive Overview
Authors: Pupaza Adelina , Cinteza Eliza , Vasile Corina Maria , Nicolescu Alin , Vatasescu Radu
Published: November 2023

Sudden cardiac death (SCD) in children is a devastating event, often linked to primary electrical diseases (PED) of the heart. PEDs, often referred to as channelopathies, are a group of genetic disorders that disrupt the normal ion channel function in cardiac cells, leading to arrhythmias and sudden cardiac death. This paper investigates the unique challenges of risk assessment and stratification for channelopathy-related SCD in pediatric patients—Brugada syndrome, catecholaminergic polymorphic ventricular tachycardia, idiopathic ventricular fibrillation, long QT syndrome, Anderson–Tawil syndrome, short QT syndrome, and early repolarization syndrome. We explore the intricate interplay of genetic, clinical, and electrophysiological factors that contribute to the complex nature of these conditions. Recognizing the significance of early identification and tailored management, this paper underscores the need for a comprehensive risk stratification approach specifically designed for pediatric populations. By integrating genetic testing, family history, and advanced electrophysiological evaluation, clinicians can enhance their ability to identify children at the highest risk for SCD, ultimately paving the way for more effective preventive strategies and improved outcomes in this vulnerable patient group.
Features of Allostatic Load in Patients with Essential Hypertension without Metabolic Syndrome Depending on the Nature of Nighttime Decreases in Blood Pressure
Authors: Zotova Tatyana , Lukanina Anastasia , Blagonravov Mikhail , Tyurina Veronika , Goryachev Vyacheslav , Bryk Anna , Sklifasovskaya Anastasia , Kurlaeva Anastasia
Published: November 2023

Changes in the activity of the renin–angiotensin–aldosterone system are responsible for a stable shift in the regulation of the cardiovascular system in essential hypertension (EH). They can be characterized as hemodynamic allostasis. The purpose of our study was to determine the role of hemodynamic parameters in allostatic load in patients with EH without metabolic syndrome. Twenty-four hours of ambulatory blood pressure monitoring was performed, followed by linear and non-linear rhythm analysis. Based on the daily index, patients with EH were divided into two groups: group 1—patients with no significant nighttime decrease in blood pressure (BP); group 2—patients who had a nocturnal decrease in BP. The control group included healthy persons aged 25 to 69 years. A linear analysis was used to determine the mean values of systolic and diastolic BP, heart rate (HR), time load of BP, circadian index, and structural point of BP. Non-linear analysis was applied to determine the mesor, amplitude, range of oscillations and % rhythm of BP and HR. The allostatic load index (ALI) was also calculated on the basis of the corresponding biomarkers. It was found that ALI was significantly higher in groups 1 and 2 in comparison with the control group. The hemodynamic mechanisms of this increase were different.
Effect of a Control Mechanism on the Interaction between a Rectangular Jet and a Slotted Plate: Experimental Study of the Aeroacoustic Field
Authors: Afyouni Nour Eldin , Alkheir Marwan , Assoum Hassan , El Zohbi Bilal , Abed-Meraim Kamel , Sakout Anas , El Hassan Mouhammad
Published: November 2023

The aeroacoustic field of a rectangular subsonic jet impinging on a slotted plate was investigated experimentally using microphones and stereoscopic particle image velocimetry (S-PIV). The study was carried out with a Reynolds number of 6700 and an impact distance of 4 cm. The current configuration represents a benchmark standpoint, featuring high levels of generated noise. A control mechanism consisting of a thin rod was introduced downstream from the jet exit to suppress the self-sustained tones. A total of 1085 positions of the rod between the jet exit and impinging plate were tested to identify positions of optimal noise reduction. Two zones were distinguished in terms of control efficacy: a zone where the sound pressure level (SPL) dropped by up to 19 dB and another zone where the SPL increased by up to 14 dB. The velocity fields show that the presence of the rod divides the jet into two lateral secondary jets on both sides of the main jet axis. The outer part of the secondary jets expanded radially with less interaction with the plate compared to the case without the control. This behavior affected the deformation of vortices against the slot. Proper orthogonal decomposition was applied to the velocity field for a better understanding of the turbulence dynamics with and without the control rod.
Application of Riemann–Liouville Derivatives on Second-Order Fractional Differential Equations: The Exact Solution
Authors: Albidah Abdulrahman B.
Published: November 2023

This paper applies two different types of Riemann–Liouville derivatives to solve fractional differential equations of second order. Basically, the properties of the Riemann–Liouville fractional derivative depend mainly on the lower bound of the integral involved in the Riemann–Liouville fractional definition. The Riemann–Liouville fractional derivative of first type considers the lower bound as a zero while the second type applies negative infinity as a lower bound. Due to the differences in properties of the two operators, two different solutions are obtained for the present two classes of fractional differential equations under appropriate initial conditions. It is shown that the zeroth lower bound implies implicit solutions in terms of the Mittag–Leffler functions while explicit solutions are derived when negative infinity is taken as a lower bound. Such explicit solutions are obtained for the current two classes in terms of trigonometric and hyperbolic functions. Some theoretical results are introduced to facilitate the solutions procedures. Moreover, the characteristics of the obtained solutions are discussed and interpreted.
Utility of Liver Biopsy in the Diagnosis and Management of Possible Drug-Induced Liver Injury in Patients Receiving Antituberculosis Therapy: A Retrospective Study
Authors: Gualano Gina , Zace Drieda , Mosti Silvia , Mencarini Paola , Musso Maria , Libertone Raffaella , Cerva Carlotta , Goletti Delia , Rianda Alessia , Del Nonno Franca , Falasca Laura , Palmieri Fabrizio
Published: November 2023

Background: Drug-induced liver injury (DILI) secondary to ATT treatment (TB-DILI) is reported in 2–28% of patients. We present here a series of clinical cases of suspected DILI arising during antituberculosis treatment, studied with the aid of liver biopsy. Methods: this was a retrospective descriptive study including 10 tuberculosis patients who underwent liver biopsy for suspected TB-DILI at the “Lazzaro Spallanzani” Institute from 2017 to 2022. Results: Ten patients who underwent LB were extracted from the database and included in the retrospective study cohort. According to the clinical classification, eight patients had hepatocellular liver injury, one patient had cholestatic injury, and another had mixed-type injury. Histopathological diagnosis revealed liver damage due to DILI in 5/10 (50%) cases. In one case, liver biopsy showed necrotizing granulomatous hepatitis. Conclusions: Severe and persistent elevation of hepatic transaminases, hepatic cholestasis despite discontinuation of therapy, and other suspected hepatic conditions are indications for liver biopsy, which remains a valuable tool in the evaluation of selected tuberculosis patients with suspected DILI for many reasons. However, the decision to perform a liver biopsy should be based on clinical judgment, considering the benefits and risks of the procedure.
A Novel Predictor for the Analysis and Prediction of Enhancers and Their Strength via Multi-View Features and Deep Forest
Authors: Gill Mehwish , Ahmed Saeed , Kabir Muhammad , Hayat Maqsood
Published: November 2023

Enhancers are short DNA segments (50–1500 bp) that effectively activate gene transcription when transcription factors (TFs) are present. There is a correlation between the genetic differences in enhancers and numerous human disorders including cancer and inflammatory bowel disease. In computational biology, the accurate categorization of enhancers can yield important information for drug discovery and development. High-throughput experimental approaches are thought to be vital tools for researching enhancers’ key characteristics; however, because these techniques require a lot of labor and time, it might be difficult for researchers to forecast enhancers and their powers. Therefore, computational techniques are considered an alternate strategy for handling this issue. Based on the types of algorithms that have been used to construct predictors, the current methodologies can be divided into three primary categories: ensemble-based methods, deep learning-based approaches, and traditional ML-based techniques. In this study, we developed a novel two-layer deep forest-based predictor for accurate enhancer and strength prediction, namely, NEPERS. Enhancers and non-enhancers are divided at the first level by NEPERS, whereas strong and weak enhancers are divided at the second level. To evaluate the effectiveness of feature fusion, block-wise deep forest and other algorithms were combined with multi-view features such as PSTNPss, PSTNPdss, CKSNAP, and NCP via 10-fold cross-validation and independent testing. Our proposed technique performs better than competing models across all parameters, with an ACC of 0.876, Sen of 0.864, Spe of 0.888, MCC of 0.753, and AUC of 0.940 for layer 1 and an ACC of 0.959, Sen of 0.960, Spe of 0.958, MCC of 0.918, and AUC of 0.990 for layer 2, respectively, for the benchmark dataset. Similarly, for the independent test, the ACC, Sen, Spe, MCC, and AUC were 0.863, 0.865, 0.860, 0.725, and 0.948 for layer 1 and 0.890, 0.940, 0.840, 0.784, and 0.951 for layer 2, respectively. This study provides conclusive insights for the accurate and effective detection and characterization of enhancers and their strengths.