bluuebunny/crossref_metadata_2025 huggingface dataset:
Independent control of amplitude and period in a synthetic oscillator circuit with modified repressilator
Authors: Zhang Fengyu , Sun Yanhong , Zhang Yihao , Shen Wenting , Wang Shujing , Ouyang Qi , Luo Chunxiong
Published: January 2022

Synthetic Biology aims to create predictable biological circuits and fully operational biological systems. Although there are methods to create more stable oscillators, such as repressilators, independently controlling the oscillation of reporter genes in terms of their amplitude and period is only on theoretical level. Here, we introduce a new oscillator circuit that can be independently controlled by two inducers in Escherichia coli. Some control components, including σECF11 and NahR, were added to the circuit. By systematically tuning the concentration of the inducers, salicylate and IPTG, the amplitude and period can be modulated independently. Furthermore, we constructed a quantitative model to forecast the regulation results. Under the guidance of the model, the expected oscillation can be regulated by choosing the proper concentration combinations of inducers. In summary, our work achieved independent control of the oscillator circuit, which allows the oscillator to be modularized and used in more complex circuit designs.
RegEnrich gene regulator enrichment analysis reveals a key role of the ETS transcription factor family in interferon signaling
Authors: Tao Weiyang , Radstake Timothy R. D. J. , Pandit Aridaman
Published: January 2022

Changes in a few key transcriptional regulators can lead to different biological states. Extracting the key gene regulators governing a biological state allows us to gain mechanistic insights. Most current tools perform pathway/GO enrichment analysis to identify key genes and regulators but tend to overlook the gene/protein regulatory interactions. Here we present RegEnrich, an open-source Bioconductor R package, which combines differential expression analysis, data-driven gene regulatory network inference, enrichment analysis, and gene regulator ranking to identify key regulators using gene/protein expression profiling data. By benchmarking using multiple gene expression datasets of gene silencing studies, we found that RegEnrich using the GSEA method to rank the regulators performed the best. Further, RegEnrich was applied to 21 publicly available datasets on in vitro interferon-stimulation of different cell types. Collectively, RegEnrich can accurately identify key gene regulators from the cells under different biological states, which can be valuable in mechanistically studying cell differentiation, cell response to drug stimulation, disease development, and ultimately drug development.
Structural insights into the potency and selectivity of covalent pan-FGFR inhibitors
Authors: Qu Lingzhi , Chen Xiaojuan , Wei Hudie , Guo Ming , Dai Shuyan , Jiang Longying , Li Jun , Yue Sitong , Chen Zhuchu , Chen Yongheng
Published: January 2022

FIIN-2, TAS-120 (Futibatinib) and PRN1371 are highly potent pan-FGFR covalent inhibitors targeting the p-loop cysteine of FGFR proteins, of which TAS-120 and PRN1371 are currently in clinical trials. It is critical to analyze their target selectivity and their abilities to overcome gatekeeper mutations. In this study, we demonstrate that FIIN-2 and TAS-120 form covalent adducts with SRC, while PRN1371 does not. FIIN-2 and TAS-120 inhibit SRC and YES activities, while PRN1371 does not. Moreover, FIIN-2, TAS-120 and PRN1371 exhibit different potencies against different FGFR gatekeeper mutants. In addition, the co-crystal structures of SRC/FIIN-2, SRC/TAS-120 and FGFR4/PRN1371 complexes reveal structural basis for kinase targeting and gatekeeper mutations. Taken together, our study not only provides insight into the potency and selectivity of covalent pan-FGFR inhibitors, but also sheds light on the development of next-generation FGFR covalent inhibitors with high potency, high selectivity, and stronger ability to overcome gatekeeper mutations.
Robust separation of topological in-plane and out-of-plane waves in a phononic crystal
Authors: Lee Myung-Joon , Oh Il-Kwon
Published: January 2022

Valley degree of freedom, associated with the valley topological phase, has propelled the advancement of the elastic waveguide by offering immunity to backscattering against bending and weak perturbations. Despite many attempts to manipulate the wave path and working frequency of the waveguide, internal characteristic of an elastic wave such as rich polarization has not yet been utilized with valley topological phases. Here, we introduce the rich polarization into the valley degree of freedom, to achieve topologically protected in-plane and out-of-plane mode separation of an elastic wave. Accidental degeneracy proves its real worth of decoupling the in-plane and out-of-plane polarized valley Hall phases. We further demonstrate independent and simultaneous control of in-plane and out-of-plane waves, with intact topological protection. The presenting procedure for designing the topologically protected wave separation based on accidental degeneracy will widen the valley topological physics in view of both generation mechanism and application areas.
All-optical quasi-monoenergetic GeV positron bunch generation by twisted laser fields
Authors: Zhao Jie , Hu Yan-Ting , Lu Yu , Zhang Hao , Hu Li-Xiang , Zhu Xing-Long , Sheng Zheng-Ming , Turcu Ion Cristian Edmond , Pukhov Alexander , Shao Fu-Qiu , Yu Tong-Pu
Published: January 2022

Generation of energetic electron-positron pairs using multi-petawatt (PW) lasers has recently attracted increasing interest. However, some previous laser-driven positron beams have severe limitations in terms of energy spread, beam duration, density, and collimation. Here we propose a scheme for the generation of dense ultra-short quasi-monoenergetic positron bunches by colliding a twisted laser pulse with a Gaussian laser pulse. In this scheme, abundant γ-photons are first generated via nonlinear Compton scattering and positrons are subsequently generated during the head-on collision of γ-photons with the Gaussian laser pulse. Due to the unique structure of the twisted laser pulse, the positrons are confined by the radial electric fields and experience phase-locked-acceleration by the longitudinal electric field. Three-dimensional simulations demonstrate the generation of dense sub-femtosecond quasi-monoenergetic GeV positron bunches with tens of picocoulomb (pC) charge and extremely high brilliance above 1014 s−1 mm−2 mrad−2 eV−1, making them promising for applications in laboratory physics and high energy physics.
Development of deep learning algorithms to discriminate giant cell tumors of bone from adjacent normal tissues by confocal Raman spectroscopy
Authors: Lau Carol P. Y. , Ma Wenao , Law Kwan Yau , Lacambra Maribel D. , Wong Kwok Chuen , Lee Chien Wei , Lee Oscar K. , Dou Qi , Kumta Shekhar M.
Published: January 2022

Confocal Raman spectroscopy accomplished by the LSTM network accurately evaluates a tumor margin by its inherent biochemiacal specificity.
The influence of Gd-DOTA conjugating ratios to PLGA-PEG micelles encapsulated IR-1061 on bimodal over-1000 nm near-infrared fluorescence and magnetic resonance imaging
Authors: Doan Thi Kim Dung , Umezawa Masakazu , Ohnuki Kazunobu , Nigoghossian Karina , Okubo Kyohei , Kamimura Masao , Yamaguchi Masayuki , Fujii Hirofumi , Soga Kohei
Published: January 2022

The bimodal OTN-NIR/MRI probe is developed from Gd-DOTA conjugating to PLGA-PEG micelles encapsulated IR-1061. The introduction ratios of Gd-DOTA regulate the interactions between the probe and the biological microenvironments.
Photoredox catalyzed cascade CF3 addition/chemodivergent annulations of ortho-alkenyl aryl ureas
Authors: Babu Sakamuri Sarath , Varma A Anagha , Gopinath Purushothaman
Published: January 2022

Photoredox catalyzed cascade addition-chemodivergent annulations of ortho-alkenyl aryl ureas.
Radical selenation of C(sp3)–H bonds to asymmetric selenides and mechanistic study
Authors: Wang Xin , Lei Jia , Guo Sa , Zhang Yan , Ye Yong , Tang Shi , Sun Kai
Published: January 2022

Herein, the oxidative radical selenation of C(sp3)–H bonds to asymmetric selenides was developed. Various C(sp3)–H bonds with ethers, thioethers, and toluene derivatives were found to be suitable substrates for this novel transformation.
CuCoFe Layered double hydroxides as laccase mimicking nanozymes for colorimetric detection of pheochromocytoma biomarkers
Authors: Huang Feng-Wei , Ma Ke , Ni Xiu-Wen , Qiao Sheng-Lin , Chen Ke-Zheng
Published: January 2022

A convenient, sensitive and reliable laccase-mimicking CuCoFe-LDHzyme was fabricated for the smartphone-based colorimetric detection of pheochromocytoma biomarkers.
Substitutional transition metal doping in MoSi2N4 monolayer: structural, electronic and magnetic properties
Authors: Abdelati Mohamed A. , Maarouf Ahmed A. , Fadlallah Mohamed M.
Published: January 2022

We find that the Sc-, Y-, Ti-, and Zr–MoSi2N4 are metallic systems, while Mn-, Tc-, and Ru–MoSi2N4 are n-type conducting. The Fe–MoSi2N4 is a dilute magnetic semiconductor.
Accelerated thermal reaction kinetics by indirect microwave heating of a microwave-transparent substrate
Authors: Tavakoli Amir , Stiegman Albert E. , Dudley Gregory B.
Published: January 2022

Selective microwave heating of polar agglomerates in solution accelerates an aryl Claisen rearrangement.
Phase segregation via etching-induced cation migration in CoSx–ZnS nanoarchitectures for solar hydrogen evolution
Authors: Shen Zirong , Huang Junmin , Chen Junying , Li Yingwei
Published: January 2022

We report the preparation of CoSx–ZnS hollow nanoframes with thin shells composed of a precisely phase-segregated CoSx/ZnS/CoSx heterojunction and its impact on solar-driven H2 production.
Nitrogen fixing bacteria facilitate microbial biodegradation of a bio-based and biodegradable plastic in soils under ambient and future climatic conditions
Authors: Tanunchai Benjawan , Kalkhof Stefan , Guliyev Vusal , Wahdan Sara Fareed Mohamed , Krstic Dennis , Schädler Martin , Geissler Andreas , Glaser Bruno , Buscot François , Blagodatskaya Evgenia , Noll Matthias , Purahong Witoon
Published: January 2022

We discovered a biological mechanism supporting microbial degradation of bio-based poly(butylene succinate-co-adipate) (PBSA) plastic in soils under ambient and future climates.
Non-contact ultrasound oocyte denudation
Authors: Mokhtare Amir , Davaji Benyamin , Xie Philip , Yaghoobi Mohammad , Rosenwaks Zev , Lal Amit , Palermo Gianpiero , Abbaspourrad Alireza
Published: January 2022

Acoustofluidic devices based on SAW are used to separate the oocyte from the cumulus oocyte complex.
The impact of the isomerism of peptide mimetics on their assembly and properties: quick and onsite gas phase detection of acids and alcohols
Authors: Chattapadhyay Deepta , Nandi Sujay Kumar , Haldar Debasish
Published: January 2022

We investigate the impact of the isomerism of peptide mimetics on their self-assembly and properties like quick and onsite detection of alcohols and acids in the gas phase.
Ultraflexible all-in-one supercapacitors with high capacitance and ultrastable cycle performance enabled by wood cellulose network
Authors: Ke Shaoqiu , Xie Di , Zhang Kai , Cheng Fangchao , Wu Yiqiang
Published: January 2022

An aligned all-in-one architecture based on a wood cellulose network endowed the ultra-flexible all-solid-state supercapacitors with elevalated electronic/ionic conductivity, high capacitance and ultrastable cycle performance.
A waste to energy approach for the effective conversion of solid waste plastics into graphene nanosheets using different catalysts for high performance supercapacitors: a comparative study
Authors: Karakoti Manoj , Pandey Sandeep , Tatrari Gaurav , Dhapola Pawan Singh , Jangra Ritu , Dhali Sunil , Pathak Mayank , Mahendia Suman , Sahoo Nanda Gopal
Published: January 2022

Conversion of plastic waste into graphene nanosheets and its application in supercapacitor.
Lithium polysulfide conformer analysis in ether-based solvents for Li–S batteries
Authors: Luque Di Salvo Javier , Luque Guillermina L. , De Luca Giorgio
Published: January 2022

Polysulfide shuttling is a major challenge impeding practical application of lithium–sulfur batteries. In this work, lithium polysulfide conformers were unravelled, providing useful insights for the design of strategies to suppress the shuttle effect.
Confining the growth of mesoporous silica films into nanospaces: towards surface nanopatterning
Authors: Soulé Samantha , Moehl Gilles E. , Huang Ruomeng , Noori Yasir J. , Kiang Kian Shen , Kees de Groot C. H. , Beanland Richard , Smith David C. , Hector Andrew L.
Published: January 2022

Mesoporous silica was deposited into e-beam patterned substrates and mesochannel orientation was controlled into nanospaces by tuning the sol chemistry opening potentialities in the fabrication of nanowire-based devices.
Plasmon enhanced light–matter interaction of rice-like nanorods by a cube-plate nanocavity
Authors: Zhang Hui , Chen Huan , Zhang Tingting , Mi Xiaohu , Jiang Zihe , Zhou Ziming , Guo Lei , Zhang Min , Zhang Zhenglong , Liu Ning , Xu Hongxing
Published: January 2022

Over 10 000 times fluorescence enhancement is achieved and small splitting is observed in both photoluminescence and scattering spectra of the NRs in the plasmonic nanocavity.
Stable graphene oxide hydrophobic photonic liquids
Authors: Xu Yi-Tao , Li Joyce , MacLachlan Mark J.
Published: January 2022

Graphene oxide photonic liquids in various hydrophobic media show highly tunable periodic structures with light reflections up to ∼1300 nm, and significantly enhanced stability at room temperature and during heating.
Optical spectra and conformation pool of tyrosine kinase inhibitor PD153035 using a robust quantum mechanical conformation search
Authors: Wang Feng , Vasilyev Vladislav , Clayton Andrew H. A.
Published: January 2022

The most potent drug configuration is not necessarily the lowest energy conformer. The optical spectral profile of a flexible TKI depends on the distribution of the conformers and therefore the conditions such as environment (solvent).
Synthesis and characterization of new 5,5′-dimethyl- and 5,5′-diphenylhydantoin-conjugated hemorphin derivatives designed as potential anticonvulsant agents
Authors: Todorov Petar , Peneva Petia , Georgieva Stela , Tchekalarova Jana , Rangelov Miroslav , Todorova Nadezhda
Published: January 2022

Herein, the synthesis and characterization of some novel N-modified hybrid analogues of hemorphins containing a C-5 substituted hydantoin residue as potential anticonvulsants and for the blockade of sodium channels are presented.
Inhibition of the formation of lysozyme fibrillar assemblies by the isoquinoline alkaloid coralyne
Authors: Basu Anirban , Mahammad Adil , Das Arindam
Published: January 2022

The isoquinoline alkaloid coralyne can efficiently attenuate fibrillogenesis in lysozyme.
Improved polarization and endurance in ferroelectric Hf0.5Zr0.5O2 films on SrTiO3(110)
Authors: Song Tingfeng , Tan Huan , Estandía Saúl , Gàzquez Jaume , Gich Martí , Dix Nico , Fina Ignasi , Sánchez Florencio
Published: January 2022

With SrTiO3(110) substrates, the ferroelectric polarization of Hf0.5Zr0.5O2 improved by 50%, with remanent polarization as high as 33 μC cm−2 in a film of less than 7 nm thickness.
Chain-growth click copolymerization for the synthesis of branched copolymers with tunable branching densities
Authors: Ma Kangling , Jin Xiuyu , Gan Weiping , Fan Chengkai , Gao Haifeng
Published: January 2022

A facile synthesis of branched polymers with regulated molecular weights, low dispersity and freely tuned branching densities is reported.
Aliphatic sulfonyl fluoride synthesis via reductive decarboxylative fluorosulfonylation of aliphatic carboxylic acid NHPI esters
Authors: Ma Zhanhu , Liu Yongan , Ma Xiaoyu , Hu Xiaojun , Guo Yong , Chen Qing-Yun , Liu Chao
Published: January 2022

A general and efficient approach to various aliphatic sulfonyl fluorides by the reductive decarboxylative fluorosulfonylation of aliphatic carboxylic acids via a radical sulfur dioxide insertion and fluorination strategy was developed.
Albumin grafted coaxial electrosparyed polycaprolactone-zinc oxide nanoparticle for sustained release and activity enhanced antibacterial drug delivery
Authors: Perera W. Pamoda Thavish D. , Dissanayake D. M. Ranga K. , Unagolla Janitha M. , De Silva Rangika T. , Bathige Sanjaya D. N. K. , Pahalagedara Lakshitha R.
Published: January 2022

Zinc oxide-cloxacillin incorporated nanoparticles coated with concentric layers of polycaprolactone and albuminviaa coaxial electrospraying technique as an enhanced and sustained antimicrobial delivery system for respiratory infections.
Electrochemical detection of mercuric(ii) ions in aqueous media using glassy carbon electrode modified with synthesized tribenzamides and silver nanoparticles
Authors: Manzoor Aalia , Kokab Tayyaba , Nawab Anam , Shah Afzal , Siddiqi Humaira Masood , Iqbal Asma
Published: January 2022

This study reports the synthesis, characterization, and mercuric ion detection ability of novel tribenzamides having flexible and rigid moieties.
Enhanced thermoelectric performance in Sb–Br codoped Bi2Se3 with complex electronic structure and chemical bond softening
Authors: Zhang Ju , Zhong Shiqi , Ke San-Huang
Published: January 2022

A detailed description of the charge density difference of BiSb(Se0.92Br0.08)3.
Achieved negative differential resistance behavior of Si/B-substituted into a C6 chain sandwiched between capped carbon nanotube junctions
Authors: Janatipour Najmeh , Mahdavifar Zabiollah , Noorizadeh Siamak , Schreckenbach Georg
Published: January 2022

Multi negative differential resistance (NDR) with large peak to valley ratio (PVR) and rectifying actions were observed for a CNT|C–(B–C)2–C|CNT molecular device.
Continuous flow technology-a tool for safer oxidation chemistry
Authors: Wan Li , Jiang Meifen , Cheng Dang , Liu Minjie , Chen Fener
Published: January 2022

The advantages and benefits of continuous flow technology for oxidation chemistry have been illustrated in tube reactors, micro-channel reactors, tube-in-tube reactors and micro-packed bed reactors in the presence of various oxidants.
The mechanism of MOF as a heterogeneous catalyst for propene hydroformylation: a DFT study
Authors: Chen Yifei , Gao Yang , Wang Lingtao , Gong Hao
Published: January 2022

M(Rh, Ir)–Cu–BTC are verified to be potential catalysts for propene hydroformylation theoretically. The electronic property of the metal center are highly sensitive with the regional selectivity.
Improving machine learning performance on small chemical reaction data with unsupervised contrastive pretraining
Authors: Wen Mingjian , Blau Samuel M. , Xie Xiaowei , Dwaraknath Shyam , Persson Kristin A.
Published: January 2022

Contrastive pretraining of chemical reactions by matching augmented reaction representations to improve machine learning performance on small reaction datasets.
Why intermolecular nitric oxide (NO) transfer? Exploring the factors and mechanistic aspects of NO transfer reaction
Authors: Das Sandip , Kulbir  , Ray Soumyadip , Devi Tarali , Ghosh Somnath , Harmalkar Sarvesh S. , Dhuri Sunder N. , Mondal Padmabati , Kumar Pankaj
Published: January 2022

Nitric oxide activation and parameters influencing intermolecular transfer of nitric oxide.
Design and optimization of a maglev electromagnetic–triboelectric hybrid energy converter for supplying power to intelligent sensing equipment
Authors: Kong Fankai , Yin Songyan , Sun Chongfei , Yang Chunhui , Chen Hailong , Liu Hengxu
Published: January 2022

An energy converter based on magnetic levitation that combines TENG and EMG ingeniously has been developed. A set of research methods combining theory, experiment and simulation of this type of model has been established.
Achieving high selectivity for nitrate electrochemical reduction to ammonia over MOF-supported RuxOy clusters
Authors: Qin Jiangzhou , Wu Kun , Chen Liuzhou , Wang Xintao , Zhao Quanlin , Liu Baojun , Ye Zhengfang
Published: January 2022

Nitrate (NO3−) electroreduction to ammonia (NH4+) is a sustainable alternative strategy for NH4+ synthesis, and it can be used to solve the water pollution problem by simultaneously turning waste into high-value ammonia.
9.6%-Efficient all-inorganic Sb2(S,Se)3 solar cells with a MnS hole-transporting layer
Authors: Qian Chen , Li Jianjun , Sun Kaiwen , Jiang Chenhui , Huang Jialiang , Tang Rongfeng , Green Martin , Hoex Bram , Chen Tao , Hao Xiaojing
Published: January 2022

Post-annealing treatment to MnS can improve the interface quality, increase the carrier concentration in MnS and optimize the band alignment, leading to a high power conversion efficiency of 9.67% and excellent stability of Sb2(S,Se)3 solar cells.
A modeling study of PEM fuel cells with novel catalyst monolayers under low platinum loading
Authors: Wu Jingtian , Liu Huiyuan , Song Yujiang , Wang Yun
Published: January 2022

Modeling of PEM fuel cells with novel catalyst monolayers under low platinum loading: validation and ORR rate in the cathode catalyst layer.
Tumor-targeting [2]catenane-based grid-patterned periodic DNA monolayer array forin vivotheranostic application
Authors: Chen Yan-Ru , Sun Shujuan , Yin Hongwei , Wang Weijun , Liu Ran , Xu Huo , Yang Ya , Wu Zai-Sheng
Published: January 2022

By cross-catenating two DNA rings containing palindromic fragments, we demonstrate a catenane-based grid-patterned periodic DNA monolayer array ([2]GDA) capable of accumulating in tumor tissues and amenable to the delivery of anticancer drugs.
Challenges and emerging opportunities in transistor-based ultrathin electronics: design and fabrication for healthcare applications
Authors: Shao Ruomei , Ma Rui , An Xuyao , Wang Chunnan , Sun Shuqing
Published: January 2022

Recent issues toward ultrathin soft electronics are gradually focused on effective detection under complex environments. The promising strategies for long-term performance are summarized as a roadmap for design and fabrication.
“Like–Likes–Like” strategy for the design of electron transport materials and emitters with facilitated interlayer electron transport and improved efficiency
Authors: Wu Yibing , Lin Rui , Iqbal Mudassir , Jin Yaocheng , Huo Yanping , Ouyang Xinhua
Published: January 2022

A novel strategy of “Like–Likes–Like” is proposed to design and synthesize the electron transport materials (ETMs) and emitters for high-performance electroluminescent devices, including similar characteristics of structures, molecular orbitals, and ground/excited-states.
Synthesis and characterization of novel dual-capped Zn–urea nanofertilizers and application in nutrient delivery in wheat
Authors: Dimkpa Christian O. , Campos Maria G. N. , Fugice Job , Glass Katherine , Ozcan Ali , Huang Ziyang , Singh Upendra , Santra Swadeshmukul
Published: January 2022

Nanoscale nutrients are promising for improving crop performance.
Hypoxia signalling in the regulation of innate immune training
Authors: Eades Lauren , Drozd Michael , Cubbon Richard M.
Published: January 2022

Innate immune function is shaped by prior exposures in a phenomenon often referred to as ‘memory’ or ‘training’. Diverse stimuli, ranging from pathogen-associated molecules to atherogenic lipoproteins, induce long-lasting training, impacting on future responses, even to distinct stimuli. It is now recognised that epigenetic modifications in innate immune cells, and their progenitors, underpin these sustained behavioural changes, and that rewired cellular metabolism plays a key role in facilitating such epigenetic marks. Oxygen is central to cellular metabolism, and cells exposed to hypoxia undergo profound metabolic rewiring. A central effector of these responses are the hypoxia inducible factors (or HIFs), which drive transcriptional programmes aiming to adapt cellular homeostasis, such as by increasing glycolysis. These metabolic shifts indirectly promote post-translational modification of the DNA-binding histone proteins, and also of DNA itself, which are retained even after cellular oxygen tension and metabolism normalise, chronically altering DNA accessibility and utilisation. Notably, the activity of HIFs can be induced in some normoxic circumstances, indicating their broad importance to cell biology, irrespective of oxygen tension. Some HIFs are implicated in innate immune training and hypoxia is present in many disease states, yet many questions remain about the association between hypoxia and training, both in health and disease. Moreover, it is now appreciated that cellular responses to hypoxia are mediated by non-HIF pathways, suggesting that other mechanisms of training may be possible. This review sets out to define what is already known about the topic, address gaps in our knowledge, and provide recommendations for future research.
Shaping axial identity during human pluripotent stem cell differentiation to neural crest cells
Authors: Cooper Fay , Tsakiridis Anestis
Published: January 2022

The neural crest (NC) is a multipotent cell population which can give rise to a vast array of derivatives including neurons and glia of the peripheral nervous system, cartilage, cardiac smooth muscle, melanocytes and sympathoadrenal cells. An attractive strategy to model human NC development and associated birth defects as well as produce clinically relevant cell populations for regenerative medicine applications involves the in vitro generation of NC from human pluripotent stem cells (hPSCs). However, in vivo, the potential of NC cells to generate distinct cell types is determined by their position along the anteroposterior (A–P) axis and, therefore the axial identity of hPSC-derived NC cells is an important aspect to consider. Recent advances in understanding the developmental origins of NC and the signalling pathways involved in its specification have aided the in vitro generation of human NC cells which are representative of various A–P positions. Here, we explore recent advances in methodologies of in vitro NC specification and axis patterning using hPSCs.
Gauge-fixed Lattice QCD and the dispersion relation of Wilson fermions
Authors: Burgio Giuseppe , Vogt Hannes
Published: January 2022

We show that, when investigating Wilson-fermions correlation functions on the lattice, one is bound to encounter major difficulties in defining their dispersion relation, even at tree level. The problem is indeed quite general and, although we stumbled upon it while studying Coulomb-gauge applications, it also affects gauge fixed studies in covariant gauges, including their most popular version, Landau gauge. In this paper we will discuss a solution to this problems based on a redefinition of the kinematic momentum of the fermion.
On boundary corrections of Lüscher-Weisz string
Authors: Khalil M.N. , Bakry A. , Chen X. , Deliyergiyev M. , Galal A. , Khalaf A. , Zhang P.M.
Published: January 2022

The potential and the density profile of the QCD flux-tube are investigated within the framework of the Luscher-Weisz (LW) string action with two boundary terms. The Numerical simulations involve 4D SU(3) Yang-Mills LGT at finite temperature. In general, we detect signatures of the two boundary terms considered in the LWstring action. Near the end of QCD Plateau, the LW string is yielding a static potential which is in a good agreement with the lattice data for source separationsR≥ 0.3 fm. However, atT/Tc= 0.9, the fit to the potential data improves with a good fit attained atR≥ 0.7 fm. The mean-square width of the energy profile atT/Tc= 0.9 matches well the width of the LW string over distance scalesR≥ 0.5 fm.
Single-spin asymmetry ATsin(2ϕ−ϕS) in π−p Drell-Yan process within TMD factorization
Authors: Li Hui , Wang Xiaoyu , Lu Zhun
Published: January 2022

We study the single-spin asymmetry ATsin(2ϕ−ϕS) in the pion-induced Drell-Yan process within the transverse momentum dependent factorization (TMD factorization). The asymmetry can be expressed as the convolution of the Boer-Mulders function and the transversity function. We numerically estimate the asymmetry ATsin(2ϕ−ϕS) at the COMPASS kinematics with the model results for the pion meson distributions from the light-cone wave function approach and the available parametrization for the proton distributions. We also include the TMD evolution formalism both proton and pion parton distribution functions by using two different parametrizations on nonperturbative Sudakov form factor. We find that the asymmetry ATsin(2ϕ−ϕS) as functions of xp, xπ, xF and q⊥ is qualitatively consistent with the recent COMPASS measurement.
Molecular interpretation of the LHCb pentaquarks from an analysis of J/ψp spectrum
Authors: Du Meng-Lin
Published: January 2022

A coupled-channel approach including the ΛcD¯(*) and ηcp channels in addition to the Σc(*)D¯(*) and J/ψp channels, as required by unitarity and heavy quark spin symmetry (HQSS), is applied to the hidden-charm pentaquark Pc states, i.e., Pc(4312), Pc(4440) and Pc(4457), discovered by LHCb Collaboration. It is demonstrated that to obtain cutoff independent results, the one-pion exchange potential in the multichannel systems is to be supplemented with next-leading order counter terms responsible for the S-wave-to-D-wave transitions. We show that the experimental data for the J/ψp mass distributions are fully in line with the ΣcD¯ and ΣcD¯* hadronic molecular interpretation of the Pc(4312) and Pc(4440)/Pc(4457), respectively. A narrow Σc*D¯ molecule around 4.38 GeV is required by the HQSS with the evidence for its existence seen in the J/ψp spectrum. Moreover, we predict the line shapes for the elastic and inelastic channels.
The static force from generalized Wilson loops using gradient flow
Authors: Leino Viljami , Brambilla Nora , Mayer-Steudte Julian , Vairo Antonio
Published: January 2022

We explore a novel approach to compute the force between a static quark-antiquark pair with the gradient flow algorithm on the lattice. The approach is based on inserting a chromoelectric field in a Wilson loop. The renormalization issues, associated with the finite size of the chromoelectric field on the lattice, can be solved with the use of gradient flow. We compare numerical results for the flowed static potential to our previous measurement of the same observable without a gradient flow.
NN interaction from chiral effective field theory and its application to neutron-antineutron oscillations
Authors: Haidenbauer Johann , Meißner Ulf-G.
Published: January 2022

An N¯N potential is introduced which is derived within chiral effective field theory and fitted to up-to-date N¯N phase shifts and inelasticities, provided by a proper phase-shift analysis of available p¯p scattering data. As an application of this interaction neutron-antineutron oscillations in the deuteron are considered. In particular, results for the deuteron lifetime are presented, evaluated in terms of the free-space n−n¯ oscillation time, utilizing that N¯N potential together with an NN interaction likewise derived within chiral effective field theory.
Inferring the dense nuclear matter equation of state with neutron star tides
Authors: Pnigouras Pantelis , Andersson Nils , Passamonti Andrea
Published: January 2022

During the late stages of a neutron star binary inspiral finite-size effects come into play, with the tidal deformability of the supranuclear density matter leaving an imprint on the gravitational-wave signal. As demonstrated in the case of GW170817—the first direct detection of gravitational waves from a neutron star binary—this can lead to strong constraints on the neutron star equation of state. As detectors become more sensitive, effects which may have a smaller influence on the neutron star tidal deformability need to be taken into consideration. Dynamical effects, such as oscillation mode resonances triggered by the orbital motion, have been shown to contribute to the tidal deformability, especially close to the neutron star coalesence, where current detectors are most sensitive. We calculate the contribution of the various stellar oscillation modes to the tidal deformability and demonstrate the (anticipated) dominance of the fundamental mode. We show what the impact of the matter composition is on the tidal deformability, as well as the changes induced by more realistic additions to the problem, e.g. the presence of an elastic crust. Finally, based on this formulation, we develop a simple phenomenological model describing the effective tidal deformability of neutron stars and show that it provides a surprisingly accurate representation of the dynamical tide close to merger.
Dilaton chiral perturbation theory and applications
Authors: Golterman Maarten , Shamir Yigal
Published: January 2022

We review dilaton chiral perturbation theory (dChPT), the effective low-energy theory for the light sector of near-conformal, confining theories. dChPT provides a systematic expansion in both the fermion mass and the distance to the conformal window. It accounts for the pions and the light scalar, the approximate Nambu–Goldstone bosons for chiral and scale symmetry, respectively. A unique feature of dChPT is the existence of a large-mass regime in which the theory exhibits approximate hyperscaling, while the expansion nevertheless remains systematic. We discuss applications to lattice data, presenting successes as well as directions for future work.
Preserving gauge invariance in neural networks
Authors: Favoni Matteo , Ipp Andreas , Müller David I. , Schuh Daniel
Published: January 2022

In these proceedings we present lattice gauge equivariant convolutional neural networks (L-CNNs) which are able to process data from lattice gauge theory simulations while exactly preserving gauge symmetry. We review aspects of the architecture and show how L-CNNs can represent a large class of gauge invariant and equivariant functions on the lattice. We compare the performance of L-CNNs and non-equivariant networks using a non-linear regression problem and demonstrate how gauge invariance is broken for non-equivariant models.
Additive manufacturing towards product production: a bibliometric analysis
Authors: Dzogbewu Thywill Cephas , Amoah Nathaniel , Fianko Samuel Korateng , Afrifa Sampson , de Beer Deon
Published: January 2022

Additively manufactured products offer extensive variety to consumers than many forms of production. Additive manufacturing (AM) production system allows consumer involvement, which has created a huge but largely untapped market. However, there is a gap between production and the market. Therefore, AM towards product production which focuses on the Commercialization of Additive Manufactured Products (CAMPs) is imperative. Despite the importance of CAMP, specific focus of research on the commercialization of additively manufactured products are scanty. There is also a lack of knowledge about the conceptual structure, intellectual structure, research trends, and the thematic structure of CAMP research. To contribute to this stream of research, this study takes an exploratory dimension by conducting a bibliometric analysis of publications on the CAMP. The R package and its associated biblioshiny were the software used. The study reveals that studies on CAMP started in 2007 with renewed interest starting from 2012. Importantly, it was found that the most cited articles focused on the economic potential of AM products in the home and specific industries. Also, there is an increasing focus on the business models that are necessary for the commercialisation of AM products. Generally, there is a shift in focus from the firm to the market. However, this is a niche area and requires more attention. Themes such as commercialization are just emerging, and researchers need to devote more time and effort to the consumer side of the commercialization of AM products.
New approach for the elucidation of the phenomena involved in the operation of vegetable oil extraction presses
Authors: Carré Patrick
Published: January 2022

In a context where the search for naturalness, the need to reduce the carbon footprint and the development of a decentralized crushing sector are intensifying, mechanical extraction is a technology that is regaining major importance for the industry. The performance of this technique remains far below what is desirable, while the understanding of the main phenomena involved in screw presses remains insufficient. This article, after a brief presentation of the state of the art of this discipline, presents a new model centered on the notions of pressure generation and plasticity. According to this approach, plasticity can account for parameters such as the water and oil content of oilseeds, their temperature, and their possible dehulling. Plasticity in turn would explain both the compressibility of the cake and its ability to resist the thrust of the screws, and consequently to generate pressure or to creep or flow backward depending on the geometry of the screw and the cage. The model must also incorporate the notions of compression velocity, friction, and the complexity of the interactions between these parameters and the impact of the succession of screw segments and cone rings. It has been built on observation and experience and gives an understanding of the need to work simultaneously on the conditioning and geometry of the presses to achieve improved performance in terms of energy, efficiency, and reduction of the temperatures experienced by the proteins and oils
Social factors as the catalyst of emigration
Authors: Pranka Maruta , Elksne Ginta , Koroleva Ilze
Published: January 2022

The objective of the study is to address the factors contributing to emigration from Latvia, in particular by highlighting the importance of social factors in the emigration decision, using the theory of push and pull factors of migration as a theoretical basis. The role of the family and the desire to improve not only the economical, but also the social and psychological conditions of families are important factors in the decision-making process, while maintaining links with Latvia. The authors argue that social factors are essential to the migration decision alongside economic factors, and in particular the family situation. The family is a resource that helps to settle in the new country of residence. The family relationship is addressed in terms of both “ontological security” and a feeling of “social anchoring”. The family remains important in maintaining links with relatives in Latvia.
Influence of different types of real-time feedback on hand washing quality assessed with neural networks/simulated neural networks
Authors: Zemlanuhina Olga , Lulla Martins , Rutkovskis Aleksejs , Slavinska Andreta , Vilde Aija , Melbarde-Kelmere Agita , Elsts Atis , Ivanov Maksims , Sabelnikovs Olegs
Published: January 2022

Background: Thousands of people die every day around the world from infections acquired in a hospital. Hands are the main pathways of germ transmission during healthcare. Hand hygiene monitoring can be performed using various methods. One of the latest techniques that can combine all is a neural network-based hand hygiene monitoring system. Methods/Design: Each participant performed 3 hand-washing trials, each time receiving different type of feedback. The order in which each participant of the study used the developed applications was strictly defined, thus each hand-washing study session started with performing hand washing using application A, B and C accordingly. All captured videos of hand-wash episodes were saved and later analysed with neural networks. In the end, both evaluation results were compared and evaluated. Results show that when the participants use Application Type A, they perform hand washing much faster, as well as in comparison of Application Type A versus application type C. However, the longest time spent for the hand washing was detected while using the application type B. Conclusion: Study shows that structured guidance provided during the real time hand washing could be associated with better overall performance. The Application C has confirmed its effectiveness. Proving its advantage among other applications, the Application C can be integrated into the clinical environment
Total quality management tools and techniques for improving service quality and client satisfaction in the healthcare environment: A qualitative systematic review
Authors: Grossu-Leibovica Dana , Kalkis Henrijs
Published: January 2022

The aim of the given research is to analyse total quality management tools for improving service quality and client satisfaction in healthcare settings through a systematic qualitative review. Data was collected through the web of sciences (WOS), Scopus, EBSCO, PubMed, and Medline. Initially, we found 573 articles from all the sources, but after eliminating the non-relevant articles, only 24 usable articles were finalized. Furthermore, 12 articles were purely related to TQM, service quality, and client satisfaction. This study concludes that TQM practices and tools improve service quality and client satisfaction in healthcare organizations. This study provides excellent managerial and practical insights. Managers should implement the TQM tools to improve service quality and client satisfaction. This way, customer satisfaction is enhanced, and patient satisfaction is improved, leading to high operational and overall performance. This study also reveals a need for further studies to clarify the role of TQM tools on service quality and patient satisfaction.
Possibilities of receptive music therapy (RMT) for mothers raising children with developmental disorders as a self-help tool for overcoming stress during the COVID-19 pandemic
Authors: Sinkuniene Jautre Ramute , Zalgiryte-Skurdeniene Jurgita
Published: January 2022

After the announcement of quarantine due to Covid-19 on March 16, 2020, parents of children with disabilities were left without help from educational and health professionals, while changes in routine, work and financial restrictions, isolation, exacerbations of children’s mental disorders increased the level of parental anxiety, tension, fear and anger. Research on music therapy conducted by the world scientists demonstrated the effectiveness of applying receptive music therapy (RMT) methods to cope with stress, when listening to music is used as a tool that can change the client’s state and help to reveal one’s experiences. The aim of the article is to reveal, theoretically and empirically, possibilities of remote application of receptive music therapy for mothers raising children with developmental disorders. Tasks: 1) to present a model of remote application of receptive music therapy for coping with stress; 2) to examine the possibilities of independent application of the developed therapeutic instrument for client’s self-help. Problem question: how can mothers use the therapeutic tool and skills acquired during the receptive music therapy on their own during the Covid-19 quarantine? The mixed data collection methodology was chosen for the research: 1) in-depth, semi-structured interview (content analysis method); 2) Perceived Stress Scale (PSS) questionnaire; 3) Musical Life Panorama (MLP) biographical interview; 4) Audio recordings of music therapy sessions – qualitative narrative analysis; 5) Music Listening Diary (MLD). Fours subjects were selected on a voluntary participatory basis by forming a homogenous group according to a similar experience of raising children with disabilities. The research revealed that remote application of RMT improved the study participants’ ability to recognize stressful situations better, feelings, and reactions arising during them, and helped them to understand their emotions better. The clients learned to apply the therapeutic instrument independently in order to relieve a stressful situation, adverse reactions, or the emerging emotions. With the formation of the habit of listening to music more often, not only did the ability to relax, not get upset, calm down was strengthened, but tension decreased and the general emotional background in the family improved. The application of RMT increased clients’ ability to cope with stress and reduced the risk of recurring stressful situations. Study participants confirmed the suitability of RMT both in remote sessions and in self-application of the instrument for self-help after the therapy during the COVID-19 quarantine.
Individual factors that cause professional burnout syndrome in social workers, employed in community rehabilitation centre for addictive diseases
Authors: Gudzinskiene Vida , Pozdniakovas Andrejus , Sinkuniene Jautre Ramute
Published: January 2022

At the theoretical and empirical levels, the article reveals individual factors that cause professional burnout syndrome in social workers, employed in community rehabilitation centre for addictive diseases. Addiction is considered a disease that has aspects of biological, psychological, social, and spiritual nature. Professional burnout syndrome can be understood from different points of view that in total comprise a general concept and consist of the following aspects: emotional exhaustion, depersonalization, and decrease in self-realization. Research object is individual factors that cause professional burnout syndrome in social workers, employed in community rehabilitation centres for addictive diseases. The aim of the article is to reveal individual factors that cause professional burnout syndrome in social workers, employed in community rehabilitation centre for addictive diseases. Tasks: 1) to provide theoretical assumptions about individual factors that cause professional burnout syndrome; 2) based on experiences of social workers to reveal individual factors that cause professional burnout syndrome in social workers, employed in community rehabilitation centre for addictive diseases. Research methods are academic literature analysis, document analysis, and qualitative research. In the study, semi-structured interviews, quality (content) analysis, summarizing method were used.Empirical research revealed that individual factors that cause the development of professional burnout syndrome in social workers, employed in community rehabilitation centres for addictive diseases, are related to: employees’ feelings of inferiority and imposition of excessive requirements on themselves (timidity, self-devaluation; feeling of guilt; lack of self-evaluation skills and imposition of excessive requirements on oneself); personal qualities (too much empathy, attachment to clients or doubts about the meaning of work); individual factors related to the environment (having nobody to talk to about problems, inability to change the environment, prolonged stress, narrowing of interests outside work, and forced abandonment of activities that previously preventively helped to combat professional burnout syndrome). Individual factors related to clients (collapse of hopes to help the client and excessive responsibility of the social worker for the client’s life). Participants of the research became “inaccessible” to family members, were unable to distance themselves from work stress (worries outside work, obsessive thoughts that hinder dissociation from work, inability to relax, use of free time for work activities); felt a lack of general and professional competencies.