bluuebunny/crossref_metadata_2025 huggingface dataset:
The pore-forming apolipoprotein APOL7C drives phagosomal rupture and antigen cross-presentation by dendritic cells
Authors: Gonzales Gerone A. , Huang Song , Wilkinson Liam , Nguyen Jenny A. , Sikdar Saif , Piot Cécile , Naumenko Victor , Rajwani Jahanara , Wood Cassandra M. , Dinh Irene , Moore Melanie , Cedeño Eymi , McKenna Neil , Polyak Maria J. , Amidian Sara , Ebacher Vincent , Rosin Nicole L. , Carneiro Matheus B. , Surewaard Bas , Peters Nathan C. , Mody Christopher H. , Biernaskie Jeff , Yates Robin M. , Mahoney Douglas J. , Canton Johnathan
Published: November 2024

Conventional dendritic cells (cDCs) generate protective cytotoxic T lymphocyte (CTL) responses against extracellular pathogens and tumors. This is achieved through a process known as cross-presentation (XP), and, despite its biological importance, the mechanism(s) driving XP remains unclear. Here, we show that a cDC-specific pore-forming protein called apolipoprotein L 7C (APOL7C) is up-regulated in response to innate immune stimuli and is recruited to phagosomes. Association of APOL7C with phagosomes led to phagosomal rupture and escape of engulfed antigens to the cytosol, where they could be processed via the endogenous MHC class I antigen processing pathway. Accordingly, mice deficient in APOL7C did not efficiently prime CD8
+
T cells in response to immunization with bead-bound and cell-associated antigens. Together, our data indicate the presence of dedicated apolipoproteins that mediate the delivery of phagocytosed proteins to the cytosol of activated cDCs to facilitate XP.
Supplemental Material: Complexity of the Oligocene meridional motion of the Philippine Sea Plate
Authors: Liu Wei , Liu Qingsong , al. et
Published: November 2024

Texts S1–S2, Figures S1–S4, Tables S1–S4, and references.  
Observation of the Polarization of Λ Hyperons Produced in the Interaction of K– Mesons with Nuclei
Authors: Abramov V. V. , Moiseev V. V. , Alekseev I. G. , Bazhanov N. A. , Borisov N. S. , Vasiliev A. N. , Goncharenko Yu. M. , Gorodnov I. S. , Gridnev A. B. , Kalugin N. K. , Kozlenko N. G. , Melnik Yu. M. , Meshchanin A. P. , Minaev N. G. , Morozov D. A. , Mochalov V. V. , Neganov A. B. , Nesterov V. M. , Novikov K. D. , Novinskii D. V. , Nogach L. V. , Nurusheva M. B. , Prudkoglyad A. F. , Ryzhikov S. V. , Rykov V. L. , Ryltsov V. V. , Ryazantsev A. V. , Samigullin E. I. , Svirida D. N. , Semenov P. A. , Uzunyan A. V. , Usov Yu. A. , Yakutin A. E.
Published: November 2024

First results on the polarization of $$\Lambda $$ hyperons inclusively produced on 26.5-GeV/c$${{K}^{ - }}$$ and $${{\pi }^{ - }}$$ beams are presented. The measurements were carried out using the SPASCHARM setup at the U-70 accelerator facility (Protvino, Russia) on nuclear targets in 2021 and 2022. The polarization of an $$\Lambda $$ hyperon on the $${{\pi }^{ - }}$$ beam does not exceed several percent in most of the studied kinematic region. The data obtained on the $${{K}^{ - }}$$-meson beam exhibit a significant positive polarization at large values of the Feynman variable xF and transverse momentum pT measured for the first time on nuclei.
Basic self-disturbance in adolescents at risk of psychosis: temporal stability investigated by the experience sampling method in a mixed method study
Authors: Baklund Lise , Røssberg Jan Ivar , Melbye Sigurd Arne , Møller Paul
Published: November 2024

Background

Basic self-disturbance (BSD), also called anomalous self-experiences (ASEs), are core phenotypic markers for schizophrenia spectrum disorders and a prepsychotic vulnerability marker considered to be temporally stable (trait-phenomenon). Studies of BSD in children and adolescents are lacking.

Objective

To be clinically useful, we need to know more about the characteristics and temporal development of BSD in prepsychotic phases.

Method

This study used a smartphone application measuring the occurrence and subjective intensity of ASEs in the daily life of 27 help-seeking adolescents (12–18 years) repeatedly over a period of 6 months. A total of 5223 unique application-reports based on individually selected and verbatim descriptions of personal core ASEs were analysed by mixed methods.

Findings

The intensity of ASEs, within subjects and between subjects and irrespective of time intervals or baseline scores obtained by the Examination of Anomalous Self-Experience (EASE) were relatively stable with a mean variability of 1.25 (0.4) SD. Participants with low EASE total scores at baseline had a significantly lower score on ASE intensity than those with high baseline EASE total scores at baseline (mean 2.42 vs 3.42, p=0.046).

Conclusion and clinical implications

In this study, ASEs were not reported as essentially fluctuating experiences but as almost constantly present, demonstrating BSD as a mainly trait phenomenon in prepsychotic phases in persons under the age of 18. Considering the continuous experience of BSD and its predictive value for psychosis development, ASEs should be targeted and monitored to the same extent as other prepsychotic features.
Assessing insomnia after stroke: a diagnostic validation of the Sleep Condition Indicator in self-reported stroke survivors
Authors: McLaren Declan M , Evans Jonathan , Baylan Satu , Harvey Monika , Montgomery Megan C , Gardani Maria
Published: November 2024

Background

Insomnia is common after stroke and is associated with poorer recovery and greater risk of subsequent strokes. Yet, no insomnia measures have been validated in English-speaking individuals affected by stroke.

Aims

This prospective diagnostic validation study investigated the discriminatory validity and optimal diagnostic cut-off of the Sleep Condition Indicator when screening for Diagnostic and Statistical Manual of Mental Disorders—fifth edition (DSM-5) insomnia disorder post-stroke.

Methods

A convenience sample of 180 (60.0% women, mean age=49.61 ± 12.41 years) community-based, adult (≥18 years) self-reported stroke survivors completed an online questionnaire. Diagnosis of DSM-5 insomnia disorder was based on analysis of a detailed sleep history questionnaire. Statistical analyses explored discriminant validity, convergent validity, relationships with demographic and mood variables, and internal consistency. Receiver operating characteristic curves were plotted to assess diagnostic accuracy.

Results

Data from the sleep history questionnaire suggested that 75 participants (41.67%) met criteria for DSM-5 insomnia disorder, 33 (18.33%) exhibited symptoms of insomnia but did not meet diagnostic criteria, and 72 (40.0%) had no insomnia symptoms at the time of assessment. The Sleep Condition Indicator (SCI) demonstrated ‘excellent’ diagnostic accuracy in the detection of insomnia post-stroke, with an area under the curve of 0.86 (95% CI (0.81, 0.91)). The optimal cut-off was determined as being ≤13, yielding a sensitivity of 88.0% and a specificity of 71.43%.

Conclusions

The findings of this study demonstrate the SCI to be a valid and reliable method with which to diagnose DSM-5 insomnia disorder and symptoms post-stroke. However, a lower threshold than is used in the general population may be necessary after stroke.
Geographical variability in cancer incidence explained by the socioeconomic environment: an example of lung cancer in northwestern France
Authors: Pouchin Pauline , Michaël Genin , Simona Bara , Nicolas Vigneron , Launoy Guy , Bryère Joséphine
Published: November 2024

Background

The incidence of lung cancer is unequally distributed in France. Although several studies have shown a link between the socioeconomic environment of populations and the incidence of cancer, the contribution has not been quantified. We aimed to analyse the geographical variability of lung cancer incidence in Normandy and calculate the proportion explained by the socioeconomic environment.

Methods

We included 7665 lung cancer cases recorded in the General Tumor Registry of Calvados and the Cancer Registry of Manche. A Bayesian model was used to map the spatial variation in the incidence of lung cancer in the territory, and an innovative approach was used to evaluate the influence of geographical variability in the socioeconomic environment on the spatial heterogeneity of lung cancer incidence.

Results

The maps of the spatial components showed high contrasts for both genders, and the socioeconomic environment integration in the model made the maps less contrasting. The socioeconomic environment of the population explained one-third of the spatial variation in the incidence of lung cancer in women and one-fifth in men.

Conclusion

The results showed that a non-negligible part of the spatial variation in the incidence of lung cancer could be explained by the geographical distribution of the socioeconomic environment.
The Benefits and Costs of Secured Debt
Authors: Benmelech Efraim
Published: November 2024

Secured debt—a debt contract that offers security to creditors in the form of collateralized assets—has been a cornerstone of credit markets in most societies since antiquity. The ability to seize and sell collateral reduces the creditor's expected losses when the debtor defaults on a promised payment. Moreover, when a firm borrows from multiple creditors with different seniorities, debt secured by assets has higher priority relative to other creditors and is first in line for payment if the firm is bankrupt. While the benefits of secured debt have been shown in both the theoretical and empirical literature, less is known about the costs associated with secured borrowing. This article surveys the burgeoning empirical literature on secured debt and provides an assessment of the costs and benefits of secured debt.
Clarifying the Concept of Professional Curiosity in Nursing: A Concept Analysis With Walker and Avant Approach
Authors: Taheri Fatemeh , Nasiri Ahmad
Published: November 2024

Background: While professional curiosity is a key attribute in nursing education and clinical practice, this is a complex and ambiguous concept in nursing and there has been limited research to explore its dimensions. Therefore, there is caution in the implementation and open discussion of this concept.

Objective: The purpose of this article is to analyze the concept of professional curiosity in nursing.

Design: The concept analysis approach developed by Walker and Avant was used to guide this manuscript.

Data Sources: A comprehensive review of the literature on professional curiosity in nursing was conducted using the electronic databases Web of Science, Scopus, Ovid, Science Direct, Google Scholar, and PubMed without a time limit until 2023. The search terms included curiosity, professional curiosity, and nursing.

Results: The antecedents, attributes, and consequences of professional curiosity were identified from 17 articles. Based on the analysis of the included articles, professional curiosity in nursing refers to nurses’ interest and enthusiasm for continuous exploration and learning, research and in‐depth investigation in the field of nursing knowledge, and patients’ experiences. The determining attributes include questioning and ongoing exploration, doubting present information, enthusiasm for discovering and learning, motivation for better understanding, creativity, professional relationships, and empathy.

Conclusion: This concept analysis helps nurses to understand the concept of professional curiosity correctly and to understand that having professional curiosity does not cross professional boundaries but is vital for increasing the quality of patient care, and this has a significant impact on their professional growth and development.
Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia With a Germline DDX41 Mutation
Authors: Yoshida Shuro , Semba Yuichiro , Takashima Shuichiro , Kadowaki Masanori , Takase Ken , Maeda Takahiro , Akashi Koichi , Iwasaki Hiromi
Published: November 2024

According to the 2016 World Health Organization classification, a germline DEAD‐box helicase 41 gene (DDX41) mutation with myeloid neoplasms has been newly classified. The clinical course of acute myeloid leukemia (AML) with a germline DDX41 mutation has not yet been clarified. In the early phase, this condition is slowly progressive, the rate of remission induction is high, and the prognosis is good. On the other hand, in the late phase, the gradual relapse rate increases and the ultimate prognosis can be poor. Currently, clear guidance on the indication for allogeneic hematopoietic stem cell transplantation (allogeneic HSCT) for AML with a germline DDX41 mutation has not been yet provided. However, we consider that allogeneic HSCT should be performed in patients who are eligible for allogeneic HSCT for germline DDX41 mutations in AML to overcome poor relapse‐free survival, referring to previous relevant papers. We report a 49‐year‐old patient who had pancytopenia and was finally diagnosed with a germline DDX41 mutation and AML. We decided to perform allogeneic HSCT. On day 68, he was complicated by acute graft versus host disease, gut stage 1, grade II, and was started on prednisolone 0.2 mg/kg. He recovered quickly and has been currently alive without symptoms of graft versus host disease for almost 2 years. Regarding donor search for allogeneic HSCT for AML with a germline DDX41 mutation, it is essential to ensure that the donor must be negative for this mutation when the donor is a family donor. If the related donor has a positive mutation, which can cause the development of donor‐derived leukemia, allogeneic HSCT should performed from an unrelated donor.
Baricitinib for the Treatment of Chronic Pruritus of Unknown Origin
Authors: Hua Wei , Tan Yingrou , Tey Hong Liang
Published: November 2024

Background: Chronic pruritus of unknown origin (CPUO) is a highly debilitating disease that lacks effective treatment. There have been case reports of effective use of Janus Kinase (JAK) inhibitors in CPUO, including a case treated with baricitinib, a selective JAK 1/2 inhibitor.

Objectives: To evaluate if itch in a cohort of CPUO patients was effectively reduced after treatment with baricitinib.

Patients and Methods: This is a retrospective case series examining all patients with CPUO who were treated with baricitinib from February 2022 to August 2023 at the National Skin Center, Singapore. Itch scores on a 0–10 numerical rating scale (NRS) at 0.5‐point intervals were recorded and analyzed over time.

Results: Sixteen patients (56% women, mean age of 62.2 ± 19.7 years old) with CPUO were included in the analysis. Their mean [range] duration of chronic itch was 15.4 [1–50] years, and the mean follow‐up period of baricitinib treatment was 10.2 ± 6.7 months. The median [IQR] NRS itch score before and after baricitinib treatment were 8.5 [6.5–10.0] and 3.5 [1.25–5.0], respectively, with a mean reduction in the itch score of 4.9 ± 2.7 (p < 0.0001). All except one patient reported significant improvement in itch severity. There were no reports of symptomatic side effects, except for a drop in hemoglobin in a patient with thalassemia and a dry throat in another patient. There were five cases of mild elevation in creatine kinase levels, three of which normalized over time, and two cases of mild elevation in creatinine levels.

Conclusion: This study suggests that baricitinib can effectively reduce pruritus in patients with CPUO and supports the conduct of randomized placebo‐controlled trials to better elucidate the efficacy of JAK inhibitors in management of CPUO.
The Influence of Rice Husk Additives on the Properties of Glass Based—Geopolymer at High Temperatures
Authors: Mohammad Shyma Hameed , Abood Al-Saadi Taha H. , Daway Entihaa G. , Mejbel Mohanad Kadhim
Published: November 2024

Foaming or porous geopolymers can be utilized in various engineering applications, including heat and acoustic insulations, as well as passive fire protection in building materials. They are ecofriendly materials, as no significant production power is required. In this study, geopolymers possessing foaming features involving lightweight and porous materials were successfully created through the reaction of sodium hydroxide solution 6 M with powder of waste glass MG without/with rice husk (RH) 20 wt.% of heat treated (212, 420, and 600 μm) utilized as the foaming agent. The effect of rice husk ash (RHA) and various sizes of RH additives on the thermal treatment (volume and weight changes, percentage), compressive strength, and microstructure (pore content) was assessed. The results show swelling (foaming behavior) for MG‐N6, MGB‐N6, MGR212‐N6, and MGR600‐N6 at 550°C, unlike the MGR420‐N6 formula. Also, a high‐volume change (percentage) for MGR420‐N6 paste at 650°C was noticed. Additionally, foaming behavior (high volume expansion) appeared for all thoughtful pastes after treatment at 750°C. The weight loss for all specimens in the range of 10%–27% and a high percentage of weight changes for MGR400‐N6 and MGR600‐N6 were noticed. Low values of compressive strength (2.74–14.5 MPa) were recorded for all formulas studied. These synthesized materials, geopolymers containing glass waste and RH powder, resulting from this study, are highly recommended, mostly for thermal and acoustic insulation materials demanding lightweight, porosity, and low mechanical properties.
On Additivity and Multiplicativity of Centrally Extended (α, β)‐Higher Derivations in Rings
Authors: Ezzat O. H.
Published: November 2024

In this paper, the concept of centrally extended (α, β)‐higher derivations is studied. It is shown to be additive in a ring without nonzero central ideals. Also, we prove that in semiprime rings with no nonzero central ideals, every centrally extended (α, β)‐higher derivation is an (α, β)‐higher derivation. Some examples are given to show that our theorems’ assumptions cannot be relaxed. The invariance problem of the center of the ring is also investigated.
Efficacy and Safety of Aurolab Aqueous Drainage Implant Compared With Baerveldt Glaucoma Implant for Refractory Glaucoma at One Year: A Systematic Review and Meta‐Analysis
Authors: Raja Sandesh , Nisar Umer , Khan Owais , Bhimani Riteeka Kumari , Raja Adarsh , Chaulagain Aayush
Published: November 2024

Background: Glaucoma stands as a prominent contributor to irreversible vision impairment on a global scale. For decades, the Baerveldt Glaucoma Implant (BGI) has been used to treat refractory glaucoma. Yet, the cost‐effective Aurolab Aqueous Drainage Implant (AADI) has gained clinical attention as a viable alternative for managing glaucoma.

Objective: The purpose of this study was to evaluate and compare the efficacy and safety of AADI and BGI in the treatment of refractory glaucoma.

Methods: Following PRISMA guidelines, we conducted a systematic search of multiple databases, identifying relevant comparative studies assessing AADI versus BGI in patients with refractory glaucoma. Key outcomes included postoperative IOP, surgical success rates, antiglaucoma medication reduction (AGMR), and complication rates. Quality assessment was performed using the Newcastle–Ottawa Scale (NOS).

Results: Three studies comprised a total of 176 individuals with refractory glaucoma, with 107 patients receiving the AADI and 69 patients receiving the BGI. The meta‐analysis revealed a statistically borderline significant reduction in postoperative IOP favoring the AADI at 3 months (mean difference [MD] = −2.74, p = 0.05). There was no significant difference in the MD of AGMR between the AADI and BGI groups. The rates of total complications and surgical success did not differ significantly between the AADI and BGI groups.

Conclusion: AADI demonstrates promising results in reducing IOP at 3 months compared to BGI, with comparable surgical outcomes and complication rates over the long term. Further studies with larger samples are warranted to validate these findings and assess cost‐effectiveness, particularly in developing countries.
Supplementary Table 4 from Disparities in Cancer Stage of Diagnosis by Rurality in California, 2015 to 2019
Authors: Oh Debora L. , Wang Katarina , Goldberg Debbie , Schumacher Karen , Yang Juan , Lin Katherine , Gomez Scarlett Lin , Shariff-Marco Salma
Published: November 2024

OR for late stage diagnosis, Hispanic
Supplementary Table S4 from Associations between Dietary Patterns and Incident Colorectal Cancer in 114,443 Individuals from the UK Biobank: A Prospective Cohort Study
Authors: Skulsky Samuel L. , Koutoukidis Dimitrios A. , Carter Jennifer L. , Piernas Carmen , Jebb Susan A. , Gao Min , Astbury Nerys M.
Published: November 2024

Table S4 Sequential adjustment of the HRs with 95% CIs for DP1’s association with incident CRC.
Supplementary Table S2 from Associations between Dietary Patterns and Incident Colorectal Cancer in 114,443 Individuals from the UK Biobank: A Prospective Cohort Study
Authors: Skulsky Samuel L. , Koutoukidis Dimitrios A. , Carter Jennifer L. , Piernas Carmen , Jebb Susan A. , Gao Min , Astbury Nerys M.
Published: November 2024

Table S2 Food groupings and their constituent food items
Supplementary Figure S5 from Associations between Dietary Patterns and Incident Colorectal Cancer in 114,443 Individuals from the UK Biobank: A Prospective Cohort Study
Authors: Skulsky Samuel L. , Koutoukidis Dimitrios A. , Carter Jennifer L. , Piernas Carmen , Jebb Susan A. , Gao Min , Astbury Nerys M.
Published: November 2024

Figure S5 DP2 Sensitivity analyses
Figure 4 from Associations between Dietary Patterns and Incident Colorectal Cancer in 114,443 Individuals from the UK Biobank: A Prospective Cohort Study
Authors: Skulsky Samuel L. , Koutoukidis Dimitrios A. , Carter Jennifer L. , Piernas Carmen , Jebb Susan A. , Gao Min , Astbury Nerys M.
Published: November 2024

DP1 associations with colorectal cancer by anatomic subsite. Top, HRs of quintile 5 versus quintile 1. Bottom, HRs of DP1 z-scores in continuous form. Unspecified (n = 68) and overlapping (n = 4) colorectal cancers were excluded as they could not be localized to an anatomic subsite. Test for trend down using LRTs. LRT, likelihood ratio test.
Supplemental Table 4. from Social, Behavioral, and Clinical Risk Factors Are Associated with Clonal Hematopoiesis
Authors: Young Corey D. , Hubbard Aubrey K. , Saint-Maurice Pedro F. , Chan Irenaeus C.C. , Cao Yin , Tran Duc , Bolton Kelly L. , Chanock Stephen J. , Matthews Charles E. , Moore Steven C. , Loftfield Erikka , Machiela Mitchell J.
Published: November 2024

Supplemental Table 4. Comparison of CH Models with Significant Associations with and without BMI Adjustment
Table 1 from High Parathyroid Hormone Rather than Low Vitamin D Is Associated with Reduced Event-Free Survival in Childhood Cancer
Authors: Grasemann Corinna , Höppner Jakob , Högler Wolfgang , Tippelt Stephan , Grasemann Maximilian , Grabow Desiree , Cario Gunnar , Zimmermann Martin , Schrappe Martin , Reinhardt Dirk , Schündeln Michael M.
Published: November 2024

Clinical characteristics of the group of patients with PTH levels below the group-median (47 pg/mL; PTH− group, first column), the patients with PTH levels ≥ the median (PTH+ group, middle column), and the entire group (last column).
Figure 1 from High Parathyroid Hormone Rather than Low Vitamin D Is Associated with Reduced Event-Free Survival in Childhood Cancer
Authors: Grasemann Corinna , Höppner Jakob , Högler Wolfgang , Tippelt Stephan , Grasemann Maximilian , Grabow Desiree , Cario Gunnar , Zimmermann Martin , Schrappe Martin , Reinhardt Dirk , Schündeln Michael M.
Published: November 2024

A and B, EFS in the entire group and in six diagnostic groups. HR and 95% confidence interval (CI) for the presence of a vitamin D deficiency (25 OH vitamin D level at or below 30 nmol/L) at any time during the 5 years following the initial diagnosis is shown in A, and for the presence of PTH levels at or above 47 pg/mL (= median of the group) is shown in B. A univariate analysis was performed.
Supplementary Table 6 from Prostate Cancer Disparities in Clinical Characteristics and Survival among Black and Latino Patients Considering Nativity: Findings from the California Cancer Registry
Authors: Freedland Alexis R. , Sanchez Mendez Joel , Liu Lihua , Hamilton Ann S. , Zhang Juanjuan , Hwang Amie E. , Ballas Leslie , Abreu Andre Luis , Deapen Dennis , Stern Mariana C.
Published: November 2024

Determinants of receipt of treatment among non-Latino white, non-Latino Black, US-born Latino, and non-US-born prostate cancer patients in California at two different time periods.
Supplementary Table S2 from Development of a Breast Cancer Risk Prediction Model Integrating Monogenic, Polygenic, and Epidemiologic Risk
Authors: Kalia Sarah S. , Boddicker Nicholas J. , Yadav Siddhartha , Huang Hongyan , Na Jie , Hu Chunling , Ambrosone Christine B. , Yao Song , Haiman Christopher A. , Chen Fei , John Esther M. , Kurian Allison W. , Guo Boya , Lindstrӧm Sara , Auer Paul , Lacey James V. , Neuhausen Susan L. , Martinez Maria Elena , Sandler Dale P. , O’Brien Katie M. , Taylor Jack A. , Teras Lauren R. , Hodge James M. , Lori Adriana , Bodelon Clara , Trentham-Dietz Amy , Burnside Elizabeth S. , Vachon Celine M. , Winham Stacey J. , Goldgar David E. , Domchek Susan M. , Nathanson Katherine L. , Weitzel Jeffrey N. , Couch Fergus J. , Kraft Peter
Published: November 2024

Supplementary Table S2 shows breast cancer risk factors and relative risks in the iCARE-Lit breast cancer risk prediction model
Supplementary Table 3 from Prostate Cancer Disparities in Clinical Characteristics and Survival among Black and Latino Patients Considering Nativity: Findings from the California Cancer Registry
Authors: Freedland Alexis R. , Sanchez Mendez Joel , Liu Lihua , Hamilton Ann S. , Zhang Juanjuan , Hwang Amie E. , Ballas Leslie , Abreu Andre Luis , Deapen Dennis , Stern Mariana C.
Published: November 2024

Sociodemographic characteristics of non-Latino White, non-Latino Black, US-born Latino, and Non-US-born Latino patients with non-imputed nativity in California (1995-2021).
Supplementary Table 1 from Prostate Cancer Disparities in Clinical Characteristics and Survival among Black and Latino Patients Considering Nativity: Findings from the California Cancer Registry
Authors: Freedland Alexis R. , Sanchez Mendez Joel , Liu Lihua , Hamilton Ann S. , Zhang Juanjuan , Hwang Amie E. , Ballas Leslie , Abreu Andre Luis , Deapen Dennis , Stern Mariana C.
Published: November 2024

Sociodemographic, clinical and treatment characteristics of non-US-born Latino PCa patients in California (1995-2021) by country of origin.
Supplemental Table 1 from Chronic Health Conditions, Disability, and Physical and Cognitive Limitations among LGBTQ+ Cancer Survivors
Authors: Waters Austin R. , Jin Mu , Jones Shaun R. , Datta Geetanjali D. , Butler Eboneé N. , Kent Erin E. , Nichols Hazel B. , Tan Kelly
Published: November 2024

Prevalence estimates restricted to states with consistent data (2020–2022)
Supplementary Table 1 from Upgrading of Grade Group 1 Prostate Cancer at Prostatectomy: Germline Risk Factors in a Prospective Cohort
Authors: Liss Michael A. , Zeltser Nicole , Zheng Yingye , Lopez Camden , Liu Menghan , Patel Yash , Yamaguchi Takafumi N. , Eng Stefan E. , Tian Mao , Semmes Oliver J. , Lin Daniel W. , Brooks James D. , Wei John T. , Klein Eric A. , Tewari Ashutosh K. , Mosquera Juan Miguel , Khani Francesca , Robinson Brian D. , Aasad Muhammad , Troyer Dean A. , Kagan Jacob , Sanda Martin G. , Thompson Ian M. , Boutros Paul C. , Leach Robin J.
Published: November 2024

Supplementary Table 1 reports results of logistic regression with two clinical predictors of upgrading.
Supplementary Table S8 from Lung Microbial and Host Genomic Signatures as Predictors of Prognosis in Early-Stage Adenocarcinoma
Authors: Tsay Jun-Chieh J. , Darawshy Fares , Wang Chan , Kwok Benjamin , Wong Kendrew K. , Wu Benjamin G. , Sulaiman Imran , Zhou Hua , Isaacs Bradley , Kugler Matthias C. , Sanchez Elizabeth , Bain Alexander , Li Yonghua , Schluger Rosemary , Lukovnikova Alena , Collazo Destiny , Kyeremateng Yaa , Pillai Ray , Chang Miao , Li Qingsheng , Vanguri Rami S. , Becker Anton S. , Moore William H. , Thurston George , Gordon Terry , Moreira Andre L. , Goparaju Chandra M. , Sterman Daniel H. , Tsirigos Aristotelis , Li Huilin , Segal Leopoldo N. , Pass Harvey I.
Published: November 2024

Supplementary Table S8: COX-PH model results of microbial profile association with time and recurrence
Supplementary Table S3 from Lung Microbial and Host Genomic Signatures as Predictors of Prognosis in Early-Stage Adenocarcinoma
Authors: Tsay Jun-Chieh J. , Darawshy Fares , Wang Chan , Kwok Benjamin , Wong Kendrew K. , Wu Benjamin G. , Sulaiman Imran , Zhou Hua , Isaacs Bradley , Kugler Matthias C. , Sanchez Elizabeth , Bain Alexander , Li Yonghua , Schluger Rosemary , Lukovnikova Alena , Collazo Destiny , Kyeremateng Yaa , Pillai Ray , Chang Miao , Li Qingsheng , Vanguri Rami S. , Becker Anton S. , Moore William H. , Thurston George , Gordon Terry , Moreira Andre L. , Goparaju Chandra M. , Sterman Daniel H. , Tsirigos Aristotelis , Li Huilin , Segal Leopoldo N. , Pass Harvey I.
Published: November 2024

Supplementary Table S3: COX proportional hazards values for alpha diversity measures associated with time to recurrence
Supplementary Table S15 from Lung Microbial and Host Genomic Signatures as Predictors of Prognosis in Early-Stage Adenocarcinoma
Authors: Tsay Jun-Chieh J. , Darawshy Fares , Wang Chan , Kwok Benjamin , Wong Kendrew K. , Wu Benjamin G. , Sulaiman Imran , Zhou Hua , Isaacs Bradley , Kugler Matthias C. , Sanchez Elizabeth , Bain Alexander , Li Yonghua , Schluger Rosemary , Lukovnikova Alena , Collazo Destiny , Kyeremateng Yaa , Pillai Ray , Chang Miao , Li Qingsheng , Vanguri Rami S. , Becker Anton S. , Moore William H. , Thurston George , Gordon Terry , Moreira Andre L. , Goparaju Chandra M. , Sterman Daniel H. , Tsirigos Aristotelis , Li Huilin , Segal Leopoldo N. , Pass Harvey I.
Published: November 2024

Supplementary Table S15: Correlation test for the identified components integrated by microbiome and transcriptome
Data from Disparities in Cancer Stage of Diagnosis by Rurality in California, 2015 to 2019
Authors: Oh Debora L. , Wang Katarina , Goldberg Debbie , Schumacher Karen , Yang Juan , Lin Katherine , Gomez Scarlett Lin , Shariff-Marco Salma
Published: November 2024

AbstractBackground:
Cancer rates in rural areas vary by insurance status, socioeconomic status, region, race, and ethnicity.
Methods:
California Cancer Registry data (2015–2019) were used to investigate the stage of diagnosis by levels of rurality for the five most common cancers. The percentage of residents in rural blocks within census tract aggregation zones was categorized into deciles up to 50%. Multivariable logistic regression was used to estimate associations with rurality, with separate models by cancer site, sex, race, and ethnicity (non-Hispanic White and Hispanic). Covariates included individual-level and zone-level factors.
Results:
The percentage of late-stage cancer diagnosis was 28% for female breast, 27% for male prostate, 77% for male lung, 71% for female lung, 60% for male colorectal, 59% for female colorectal, 7.8% for male melanoma, and 5.9% for female melanoma. Increasing rurality was significantly associated with increased odds of late-stage cancer diagnosis for female breast cancer (Ptrend < 0.001), male lung cancer (Ptrend < 0.001), female lung cancer (Ptrend < 0.001), and male melanoma (Ptrend = 0.01), after adjusting for individual-level and zone-level factors. The strength of associations varied by sex and ethnicity. For males with lung cancer, odds of late-stage diagnosis in areas with >50% rural population was 1.24 (95% confidence interval, 1.06–1.45) for non-Hispanic White patients and 2.14 (95% confidence interval, 0.86–5.31) for Hispanic patients, compared with areas with 0% rural residents.
Conclusions:
Increasing rurality was associated with increased odds for late-stage diagnosis for breast cancer, lung cancer, and melanoma, with the strength of associations varying across sex and ethnicity.
Impact:
Our findings will inform cancer outreach to these rural subpopulations.
Data from Associations between Dietary Patterns and Incident Colorectal Cancer in 114,443 Individuals from the UK Biobank: A Prospective Cohort Study
Authors: Skulsky Samuel L. , Koutoukidis Dimitrios A. , Carter Jennifer L. , Piernas Carmen , Jebb Susan A. , Gao Min , Astbury Nerys M.
Published: November 2024

AbstractBackground:
Diet–disease association studies increasingly use dietary patterns (DP) to account for the complexity of the exposure. We assessed if a DP associated with type 2 diabetes mellitus, cardiovascular disease, and all-cause mortality is also associated with colorectal cancer.
Methods:
We used reduced rank regression on 24-hour recall data to identify DPs, explaining the maximum variation in four nutrient-response variables: energy density, saturated fatty acids, free sugars, and fiber density. Cox proportional hazards models examined prospective associations between DP adherence (coded in a continuous scale as z-scores as well as in quintiles) and incident colorectal cancer. Subgroup analyses were conducted for tumor site, age, and sex.
Results:
After exclusions, 1,089 colorectal cancer cases occurred in 114,443 participants over a median follow-up of 8.0 years. DP1 was characterized by increased intake of chocolate and confectionery; butter; low-fiber bread; red and processed meats; and alcohol, as well as low intake of fruits, vegetables, and high-fiber cereals. After accounting for confounders, including body mass, there were positive linear associations between DP1 and incident overall colorectal cancer (HR of quintile 5 vs. 1, 1.34; 95% confidence interval, 1.16–1.53, Ptrend = 0.005) and rectal cancer (HR of quintile 5 vs. 1, 1.58; 95% confidence interval, 1.27–1.96, Ptrend = 0.009) but not for proximal or distal colon cancers. No DP2–colorectal cancer association was observed.
Conclusions:
A DP previously associated with cardiometabolic disease is also associated with incident colorectal cancer, especially rectal cancers.
Impact:
These consistent associations of particular food groups with both cardiometabolic disease and this diet-related cancer strengthen the evidence base for holistic population dietary guidelines to prevent ill-health.
Data from High Parathyroid Hormone Rather than Low Vitamin D Is Associated with Reduced Event-Free Survival in Childhood Cancer
Authors: Grasemann Corinna , Höppner Jakob , Högler Wolfgang , Tippelt Stephan , Grasemann Maximilian , Grabow Desiree , Cario Gunnar , Zimmermann Martin , Schrappe Martin , Reinhardt Dirk , Schündeln Michael M.
Published: November 2024

AbstractBackground:
Vitamin D deficiency is linked to poor cancer outcomes but the impact of its consequence, elevated parathyroid hormone (PTH), remains understudied. PTH receptor activation influences cancer progression in vitro, yet the effect of elevated PTH on pediatric cancer survival is unexamined.
Methods:
This retrospective study examines associations between PTH, 25-OH vitamin D (25OHD), and event-free survival (EFS) and overall survival (OS) in patients with pediatric cancer. Laboratory data from 4,349 patients (0–18 years) at a tertiary pediatric cancer unit were analyzed for the highest PTH and lowest 25OHD levels at diagnosis and the following 5 years. Data on relapse, secondary malignancies, and mortality were stratified by PTH levels above/below the cohort median (47 pg/mL) and 25OHD levels ≤30 nmol/L. EFS and OS were analyzed and hazard ratios (HR) were calculated for the entire cohort and six cancer subgroups.
Results:
PTH and 25OHD values were available for 1,286 patients (731 male). Higher PTH associated with inferior EFS in primary malignant brain tumors [HR, 1.80 (1.19–2.72)], embryonal malignancies [HR, 2.20 (1.1–4.43)], and lymphatic malignancies [HR 1.98 (1.05–3.72)]. Vitamin D deficiency associated with inferior EFS in embryonal malignancies [HR 2.41 (1.24–4.68)]. In a multivariate Cox model, only higher PTH remained significant for inferior EFS.
Conclusions:
Elevated PTH may indicate adverse outcomes in certain pediatric cancers.
Impact:
This study identifies elevated parathyroid hormone as a potential marker for poor outcomes in patients with pediatric cancer, emphasizing the need for adequate vitamin D and calcium management.
Data from Development of a Breast Cancer Risk Prediction Model Integrating Monogenic, Polygenic, and Epidemiologic Risk
Authors: Kalia Sarah S. , Boddicker Nicholas J. , Yadav Siddhartha , Huang Hongyan , Na Jie , Hu Chunling , Ambrosone Christine B. , Yao Song , Haiman Christopher A. , Chen Fei , John Esther M. , Kurian Allison W. , Guo Boya , Lindstrӧm Sara , Auer Paul , Lacey James V. , Neuhausen Susan L. , Martinez Maria Elena , Sandler Dale P. , O’Brien Katie M. , Taylor Jack A. , Teras Lauren R. , Hodge James M. , Lori Adriana , Bodelon Clara , Trentham-Dietz Amy , Burnside Elizabeth S. , Vachon Celine M. , Winham Stacey J. , Goldgar David E. , Domchek Susan M. , Nathanson Katherine L. , Weitzel Jeffrey N. , Couch Fergus J. , Kraft Peter
Published: November 2024

AbstractBackground:
Breast cancer has been associated with monogenic, polygenic, and epidemiologic (clinical, reproductive, and lifestyle) risk factors, but studies evaluating the combined effects of these factors have been limited.
Methods:
We extended previous work in breast cancer risk modeling, incorporating pathogenic variants (PV) in six breast cancer predisposition genes and a 105-SNP polygenic risk score (PRS), to include an epidemiologic risk score (ERS) in a sample of non-Hispanic White women drawn from prospective cohorts and population-based case–control studies, with 23,518 cases and 22,832 controls, from the Cancer Risk Estimates Related to Susceptibility (CARRIERS) Consortium.
Results:
The model predicts 4.4-fold higher risk of breast cancer for postmenopausal women with no predisposition PV and median PRS, but with the highest versus lowest ERS. Overall, women with CHEK2 PVs had >20% lifetime risk of breast cancer. However, 15.6% of women with CHEK2 PVs and a family history of breast cancer, and 45.1% of women with CHEK2 PVs but without a family history of breast cancer, had low (<20%) predicted lifetime risk and thus were below the threshold for MRI screening. CHEK2 PV carriers at the 10th percentile of the joint distribution of ERS and PRS, without a family history of breast cancer, had a predicted lifetime risk similar to the general population.
Conclusions:
These results illustrate that an ERS, alone and combined with the PRS, can contribute to clinically relevant risk stratification.
Impact:
Integrating monogenic, polygenic, and epidemiologic risk factors in breast cancer risk prediction models may inform personalized screening and prevention efforts.
Data from Upgrading of Grade Group 1 Prostate Cancer at Prostatectomy: Germline Risk Factors in a Prospective Cohort
Authors: Liss Michael A. , Zeltser Nicole , Zheng Yingye , Lopez Camden , Liu Menghan , Patel Yash , Yamaguchi Takafumi N. , Eng Stefan E. , Tian Mao , Semmes Oliver J. , Lin Daniel W. , Brooks James D. , Wei John T. , Klein Eric A. , Tewari Ashutosh K. , Mosquera Juan Miguel , Khani Francesca , Robinson Brian D. , Aasad Muhammad , Troyer Dean A. , Kagan Jacob , Sanda Martin G. , Thompson Ian M. , Boutros Paul C. , Leach Robin J.
Published: November 2024

AbstractBackground:
Localized prostate tumors show significant spatial heterogeneity, with regions of high-grade disease adjacent to lower grade disease. Consequently, prostate cancer biopsies are prone to sampling bias, potentially leading to underestimation of tumor grade. To study the clinical, epidemiologic, and molecular hallmarks of this phenomenon, we conducted a prospective study of grade upgrading: differences in detected prostate cancer grade between biopsy and surgery.
Methods:
We established a prospective, multi-institutional cohort of men with grade group 1 (GG1) prostate cancer on biopsy who underwent radical prostatectomy. Upgrading was defined as detection of GG2+ in the resected tumor. Germline DNA from 192 subjects was subjected to whole-genome sequencing to quantify ancestry, pathogenic variants in DNA damage response genes, and polygenic risk.
Results:
Of 285 men, 67% upgraded at surgery. PSA density and percent of cancer in pre-prostatectomy positive biopsy cores were significantly associated with upgrading. No assessed genetic risk factor was predictive of upgrading, including polygenic risk scores for prostate cancer diagnosis.
Conclusions:
In a cohort of patients with low-grade prostate cancer, a majority upgraded at radical prostatectomy. PSA density and percent of cancer in pre-prostatectomy positive biopsy cores portended the presence of higher-grade disease, while germline genetics was not informative in this setting. Patients with low-risk prostate cancer, but elevated PSA density or percent cancer in positive biopsy cores, may benefit from repeat biopsy, additional imaging or other approaches to complement active surveillance.
Impact:
Further risk stratification of patients with low-risk prostate cancer may provide useful context for active surveillance decision-making.
Supplementary Table 5 from Clinical and Genomic Features of Classical and Basal Transcriptional Subtypes in Pancreatic Cancer
Authors: Singh Harshabad , Xiu Joanne , Kapner Kevin S. , Yuan Chen , Narayan Raja R. , Oberley Matthew , Farrell Alex , Surana Rishi , Huffman Brandon M. , Perez Kimberly , Cleary James M. , Jordan Alexander C. , Dias Costa Andressa , Williams Hannah L. , Raghavan Srivatsan , Weinberg Benjamin , Pishvaian Michael J. , Shroff Rachna T. , Goel Sanjay , Dougan Stephanie K. , Nowak Jonathan A. , Spetzler David , Sledge George , Wolpin Brian M. , Aguirre Andrew J.
Published: November 2024

Supplementary Table 5
Supplementary Table 2 from Clinical and Genomic Features of Classical and Basal Transcriptional Subtypes in Pancreatic Cancer
Authors: Singh Harshabad , Xiu Joanne , Kapner Kevin S. , Yuan Chen , Narayan Raja R. , Oberley Matthew , Farrell Alex , Surana Rishi , Huffman Brandon M. , Perez Kimberly , Cleary James M. , Jordan Alexander C. , Dias Costa Andressa , Williams Hannah L. , Raghavan Srivatsan , Weinberg Benjamin , Pishvaian Michael J. , Shroff Rachna T. , Goel Sanjay , Dougan Stephanie K. , Nowak Jonathan A. , Spetzler David , Sledge George , Wolpin Brian M. , Aguirre Andrew J.
Published: November 2024

Supplementary Table 2
Supplementary Table 10 from Clinical and Genomic Features of Classical and Basal Transcriptional Subtypes in Pancreatic Cancer
Authors: Singh Harshabad , Xiu Joanne , Kapner Kevin S. , Yuan Chen , Narayan Raja R. , Oberley Matthew , Farrell Alex , Surana Rishi , Huffman Brandon M. , Perez Kimberly , Cleary James M. , Jordan Alexander C. , Dias Costa Andressa , Williams Hannah L. , Raghavan Srivatsan , Weinberg Benjamin , Pishvaian Michael J. , Shroff Rachna T. , Goel Sanjay , Dougan Stephanie K. , Nowak Jonathan A. , Spetzler David , Sledge George , Wolpin Brian M. , Aguirre Andrew J.
Published: November 2024

Supplementary Table 10
Supplementary Table 1 from Clinical and Genomic Features of Classical and Basal Transcriptional Subtypes in Pancreatic Cancer
Authors: Singh Harshabad , Xiu Joanne , Kapner Kevin S. , Yuan Chen , Narayan Raja R. , Oberley Matthew , Farrell Alex , Surana Rishi , Huffman Brandon M. , Perez Kimberly , Cleary James M. , Jordan Alexander C. , Dias Costa Andressa , Williams Hannah L. , Raghavan Srivatsan , Weinberg Benjamin , Pishvaian Michael J. , Shroff Rachna T. , Goel Sanjay , Dougan Stephanie K. , Nowak Jonathan A. , Spetzler David , Sledge George , Wolpin Brian M. , Aguirre Andrew J.
Published: November 2024

Supplementary Table 1
Supplementary Methods 1 from Clinical and Genomic Features of Classical and Basal Transcriptional Subtypes in Pancreatic Cancer
Authors: Singh Harshabad , Xiu Joanne , Kapner Kevin S. , Yuan Chen , Narayan Raja R. , Oberley Matthew , Farrell Alex , Surana Rishi , Huffman Brandon M. , Perez Kimberly , Cleary James M. , Jordan Alexander C. , Dias Costa Andressa , Williams Hannah L. , Raghavan Srivatsan , Weinberg Benjamin , Pishvaian Michael J. , Shroff Rachna T. , Goel Sanjay , Dougan Stephanie K. , Nowak Jonathan A. , Spetzler David , Sledge George , Wolpin Brian M. , Aguirre Andrew J.
Published: November 2024

Supplementary Methods
Supplementary Table S5 from Exploiting WEE1 Kinase Activity as FUS::DDIT3-Dependent Therapeutic Vulnerability in Myxoid Liposarcoma
Authors: Heinst Lorena , Lee Kwang Seok , Berthold Ruth , Isfort Ilka , Wosnig Svenja , Kuntze Anna , Hafner Susanne , Altvater Bianca , Rossig Claudia , Åman Pierre , Wardelmann Eva , Scholl Claudia , Hartmann Wolfgang , Fröhling Stefan , Trautmann Marcel
Published: November 2024

Supplementary Table S5. Densitometric analysis of western blot results (Figure 3A). WEE1 activity is required for genomic integrity and survival of MLS 402-91 (left) and MLS 1765-92 (right) cells.
Supplementary Table S1 from Exploiting WEE1 Kinase Activity as FUS::DDIT3-Dependent Therapeutic Vulnerability in Myxoid Liposarcoma
Authors: Heinst Lorena , Lee Kwang Seok , Berthold Ruth , Isfort Ilka , Wosnig Svenja , Kuntze Anna , Hafner Susanne , Altvater Bianca , Rossig Claudia , Åman Pierre , Wardelmann Eva , Scholl Claudia , Hartmann Wolfgang , Fröhling Stefan , Trautmann Marcel
Published: November 2024

Supplementary Table S1. Primary antibodies.
Supplementary Figure S6 from Exploiting WEE1 Kinase Activity as FUS::DDIT3-Dependent Therapeutic Vulnerability in Myxoid Liposarcoma
Authors: Heinst Lorena , Lee Kwang Seok , Berthold Ruth , Isfort Ilka , Wosnig Svenja , Kuntze Anna , Hafner Susanne , Altvater Bianca , Rossig Claudia , Åman Pierre , Wardelmann Eva , Scholl Claudia , Hartmann Wolfgang , Fröhling Stefan , Trautmann Marcel
Published: November 2024

Supplementary Figure S6. CDK 2 expression exacerbates replication stress in MLS.
Supplementary Data 1 from Tumor-Infiltrating Lymphocytes in Necrotic Tumors after Melanoma Neoadjuvant Anti–PD-1 Therapy Correlate with Pathologic Response and Recurrence-Free Survival
Authors: Ma Kevin L. , Mitchell Tara C. , Dougher Meaghan , Sharon Cimarron E. , Tortorello Gabriella N. , Elder David E. , Morgan Eric E. , Gimotty Phyllis A. , Huang Alexander C. , Amaravadi Ravi K. , Schuchter Lynn M. , Flowers Ahron , Miura John T. , Karakousis Giorgos C. , Xu Xiaowei
Published: November 2024

All supplemental data (Supp Figs S1-S4)
Supplementary Figure S1 from A Histopathologic Correlation Study Evaluating Glymphatic Function in Brain Tumors by Multiparametric MRI
Authors: Gao Min , Liu Zhengliang , Zang Hongjing , Wu Xiong , Yan Yizhong , Lin Hai , Yuan Jianmin , Liu Tianming , Zhou Yu , Liu Jun
Published: November 2024

Supplementary Figure S1: Raincloud plots of between-group comparisons in MR measurement data of patients and healthy controls.
Supplementary Table S3 from FDA Approval Summary: Enfortumab Vedotin plus Pembrolizumab for Locally Advanced or Metastatic Urothelial Carcinoma
Authors: Brave Michael H. , Maguire William F. , Weinstock Chana , Zhang Hui , Gao Xin , Li Fang , Yu Jingyu , Fu Wentao , Zhao Hong , Pierce William F. , Chang Elaine , Dinin Jeannette , Fiero Mallorie H. , Rahman Nam Atiqur , Tang Shenghui , Pazdur Richard , Kluetz Paul G. , Amiri-Kordestani Laleh , Suzman Daniel L.
Published: November 2024

PFS and OS by Availability of Post-Protocol Avelumab and EV
Supplementary Table S2 from FDA Approval Summary: Enfortumab Vedotin plus Pembrolizumab for Locally Advanced or Metastatic Urothelial Carcinoma
Authors: Brave Michael H. , Maguire William F. , Weinstock Chana , Zhang Hui , Gao Xin , Li Fang , Yu Jingyu , Fu Wentao , Zhao Hong , Pierce William F. , Chang Elaine , Dinin Jeannette , Fiero Mallorie H. , Rahman Nam Atiqur , Tang Shenghui , Pazdur Richard , Kluetz Paul G. , Amiri-Kordestani Laleh , Suzman Daniel L.
Published: November 2024

Percentage of patients with resolution of peripheral neuropathy at last assessment of neuropathy in EV monotherapy ISS and EV + Pembro combination pools
Supplementary Figure S1 from FDA Approval Summary: Enfortumab Vedotin plus Pembrolizumab for Locally Advanced or Metastatic Urothelial Carcinoma
Authors: Brave Michael H. , Maguire William F. , Weinstock Chana , Zhang Hui , Gao Xin , Li Fang , Yu Jingyu , Fu Wentao , Zhao Hong , Pierce William F. , Chang Elaine , Dinin Jeannette , Fiero Mallorie H. , Rahman Nam Atiqur , Tang Shenghui , Pazdur Richard , Kluetz Paul G. , Amiri-Kordestani Laleh , Suzman Daniel L.
Published: November 2024

Kaplan-Meier curves of BICR-assessed progression-free survival in EV-302