bluuebunny/crossref_metadata_2025 huggingface dataset:
PUERTO RICO AS ISLAND OF KNOWLEDGE: LESSONS LEARNED FROM SUCCESSFUL ENTREPRENEURS
Authors: Flores-Caraballo Eliut Daniel
Published: July 2024

Entrepreneurs from 10 different companies in the knowledge economy sector of Puerto Rico (PR), varying in operation from two to 25 years, were interviewed to understand which innovation ecosystem elements have contributed or hindered their companies’ growth. We learn about the journey of these companies and explore their leaders’ perception of how creating and operating a knowledge company in PR benefits or hampers their businesses. Entrepreneurs assess what could the commercial sector, educational institutions, and the government do to help their companies be more successful. They also reflect on the concept of Puerto Rico as an Island of Knowledge. Through the analysis of ten case studies, the article provides original and valuable insight into the entrepreneurial ecosystem in Puerto Rico to help researchers and policy makers understand the opportunities and pitfalls faced by Island-based innovators seeking to make their mark in the knowledge economy. We conclude that Puerto Rico is an Island of Knowledge in progress. The innovation ecosystem is currently growing but it remains smaller than needed to foster explosive growth. We found that entrepreneurship and company acceleration programs are having positive impact in growing the creation and sustainability of new knowledge companies on the Island. Puerto Rico is a good source of human capital for knowledge enterprises, but it could do better. Schools and universities need to teach entrepreneurship and bring more students to tech careers. Higher education curricula needs to be updated to cover a variety of new technologies and provide a myriad of practical skills and technical certifications to make graduates productive on day 1. Government and employers alike need to implement creative strategies to retain qualified talent on the Island.
CORPORATE CHALLENGE CANVAS: FERRAMENTA VISUAL PARA SISTEMATIZAR DESAFIOS DE OPEN INNOVATION / CORPORATE CHALLENGE CANVAS: VISUAL TOOL TO SYSTEMATIZE OPEN INNOVATION CHALLENGES
Authors: DE CARVALHO LARCHER PINTO THAIS , Bauer Tamanine Andréa Maristela
Published: July 2024

ResumoO engajamento entre grandes empresas e startups, intitulado Corporate Startup Engagement (CSE), é cada vez mais utilizado como estratégia corporativa em processos de inovação aberta. No intuito de contribuir para que o relacionamento entre grandes empresas e startups seja mais assertivo e colaborativo, o artigo visa apresentar parte do trabalho de pesquisa realizado no Programa de Mestrado Profnit, que teve como objetivo o desenvolvimento de uma ferramenta visual para a sistematização de desafios corporativos em interações de baixa maturidade com startups. Acredita-se que a sistematização das principais informações que devem estar disponíveis num desafio corporativo, tanto para compartilhá-lo com o ambiente externo – startup, programas, editais etc. – como no ambiente interno, é importante para a melhoria das interações. Utilizou-se a metodologia do Duplo Diamante, com a aplicação de métodos e ferramentas de gestão e design, para elaborar a ferramenta visual que foi testada e validada em um workshop. Concluiu-se que abordagens que possibilitem o levantamento e o registro sistematizado de desafios corporativos, utilizando-se de ferramentas visuais, podem colaborar para ampliar as taxas de sucesso no engajamento entre grandes empresas e startups. Palavras-chave: Inovação aberta. Grandes empresas. Startups. Canvas. Desafio. AbstractThe engagement between large companies and startups, called Corporate Startup Engagement (CSE), is increasingly used as a corporate strategy in open innovation processes. In order to contribute to making the relationship between large companies and startups more assertive and collaborative, the article aims to present part of the research work carried out in the Profnit Master's Program, which aimed to develop a visual tool for the systematization of challenges companies in low-maturity interactions with startups. It is believed that the systematization of the main information that must be available in a corporate challenge, both to share it with the external environment – startup, programs, public notices, etc. – as in the internal environment, is important for the improvement of interactions. The Double Diamond methodology was used, with the application of management and design methods and tools, to develop the visual tool that was tested and validated in a workshop. It was concluded that approaches that allow the systematic survey and recording of corporate challenges using visual tools can collaborate to increase the success rates in engagement between large companies and startups. Keywords: Open innovation. Large companies. Startups. Canvas. Challenge.
THE INFLUENCE OF PUBLIC POLICIES FOR DEVELOPMENT OF ST&I IN BRAZIL: THE ANALYSIS OF THE SNCTI INDICATORS
Authors: Dos Santos Ana Cristina , Carvalho Ana Cristina de Lima Cardoso , Gobbi Paulo Eduardo Mascarello , Soares Paula Meyer , Bijos Leila Maria da Juda
Published: July 2024

The National System of Science, Technology and Innovation (SNCTI) in Brazil comprises an environment formed by public and private institutions, funding agencies, research companies, in addition to a number of instruments instituted in favor of the development of Science, Technology and Innovation activities - ST&I. These constitutive milestones are outlined in the document Estratégia Nacional de Ciência, Tecnologia e Inovação 2016|2022 (ENCTI), where the Government defined guidelines, rules, challenges and goals to promote ST&I in Brazil. The purpose of this article is to discuss the challenge of positioning Brazil among the most developed countries in ST&I, defined in the ENCTI planning for the period 2016-2021. It is also intended to to present and analyze the performance of the two goals defined for this challenge - the first target related to expenditure on research and development - R&D and the second to the human resources active in the R&D. The factors that may have influenced the results complement the study This study used the empirical methodology, with data collection carried out by bibliographic research of secondary sources for data collection and analysis. The data collected covered the period from 2016 to 2019 extracted from the official database. In the analysis, a comparison was made with data from the previous period to verify the evolution of Brazilian performance and the achievement of goals. At the end, the discussion presents the results of the goals and the challenge projected in the ENCTI document, with the performance of indicators from the data collected.
DOI: 10.18226/23190639.v10n2.07
PRÁTICAS DE ECOINOVAÇÃO E PROCESSOS DE NEGÓCIOS NA GESTÃO DA CADEIA DE SUPRIMENTOS MOVELEIRA:
Authors: Troccoli Marques da Silva Natalia , Aparecida Santini Pigatto Giuliana , Guilherme Satolo Eduardo
Published: July 2024

A indústria moveleira brasileira é responsável por fomentar uma parte significativa da economia. O processo produtivo ainda tradicional e a sua principal matéria-prima, a madeira, exigem a utilização de diversos recursos naturais e, juntamente, com demais materiais necessários para a elaboração de produtos, o setor produz quantidade relevante de resíduos. Essas situações necessitam de procedimentos adequados para reduzir prejuízos ao meio ambiente. Diante da necessidade da adequação das empresas para um modelo menos prejudicial ao meio ambiente, o estudo apresenta como objetivo analisar as relações entre as práticas de ecoinovação e os processos de negócios na gestão da cadeia de suprimentos moveleira, com propósito da elaboração de modelo de análise. Por meio dos conceitos de gestão da cadeia de suprimentos moveleira e ecoinovação, elaborou-se um modelo para análise das relações entre eles. Utilizou-se como método a pesquisa de literatura do setor e revisão sistemática de literatura. Identificou-se os processos de negócios suscetíveis para aplicação das práticas de ecoinovação à gestão da cadeia de suprimentos moveleira. Concluiu-se que as práticas de ecoinovação estão relacionadas com os processos de negócios gestão do relacionamento com o cliente, gestão de manufatura, gestão de relacionamento com fornecedores, desenvolvimento de produtos e comercialização e gestão de retorno, e essas práticas podem ser aplicadas para a obtenção de benefícios ambientais, contribuindo para a melhor compreensão da aplicabilidade da ecoinovação na indústria moveleira.
TRANSPARENCY AND MUNICIPAL PUBLIC MANAGEMENT:
Authors: Pereira Ricardo , Silva Pereira Vinícius
Published: July 2024

Based on the massification of access to information due to the improvement and dissemination of computer technologies on the network, especially from the 1970s onwards, new parameters of transparency and publicity for management acts were established in the public sector. The so-called electronic transparency portals emerged as a means to implement the premises of this new paradigm of opening state secrets, as well as the accountability of state agents. The present study was interested in analyzing the specific reality, in its virtues and shortcomings, of the electronic portals of the municipalities that make up the geographic region of Uberlândia, Minas Gerais, Brazil, in the earliest variable period, with data available, up to the year 2021. For this purpose, strategies such as obtaining data according to the parameters of the “Índice de Transparência da Gestão Pública Municipal (ITGP-M)”, understood as Transparency Index of Municipal Public Management, were used in order to interpret them through a qualitative, descriptive, applied and documental methodological approach. The results allowed concluding the prevalence of attendance to formal aspects, such as the publication of municipal legislation and planning elements, and the lack of instruments to effect the interaction of municipal administrations with citizens and society organizations.
GESTÃO DA INOVAÇÃO e TRANSFORMAÇÃO CULTURAL: CASO DE AÇÕES INDUTIVAS EM UMA FUNDAÇÃO DE APOIO A INSTITUIÇÃO DE ENSINO SUPERIOR | INNOVATION MANAGEMENT AND CULTURAL TRANSFORMATION: CASE OF INDUCTIVE INITIATIVES IN BRAZILIAN SUPPORT FOUNDATION
Authors: Cintra Leandro Pinheiro , Braga Renato Costa , Barbosa Allan Claudius Queiroz
Published: July 2024

As inovações nas organizações têm demanda crescente a cada ano, o que suscita gestão e estimulo ao processo para sua geração de forma sistemática e engajada. A inovação surge, neste contexto, como uma função organizacional nas empresas, o que exige gestão das práticas com ambidestralidade. Sob essa perspectiva, o objetivo desse artigo é discutir a percepção dos funcionários de uma Fundação de Apoio a Instituição de Ensino Superior (FIES), no que diz respeito a iniciativas de indução à inovação por meio de um programa institucional de transformação cultural. Optou-se por abordagem qualitativa descritiva e estratégia estudo de caso único, integrado. Buscou-se triangular e validar dados coletados de fontes variadas, relacionados à percepção dos funcionários (internos); dos agentes de aceleração da inovação (externos); de resultados dos funcionários na gamificação do programa institucional; e de documentos internos na Intranet. Foi possível identificar aspectos ligados ao engajamento e desenvolvimento dos participantes; a dificuldade de compatibilização da rotina de trabalho com as iniciativas de inovação; variações relacionadas ao envolvimento dos colaboradores e ao apoio das lideranças; percepções da importância do programa para desenvolvimento pessoal e profissional; e evidências de transformação da cultura na direção de mais inovações. Os resultados trazem contribuições para se ampliar a discussão sobre a função inovação, Gestão 3.0, o papel das lideranças, práticas de transformação para uma cultura de inovação e seus desafios. Sugerem-se mais pesquisas em organizações com mesma natureza. DOI: 10.18226/23190639.v9n3.03 Leandro Pinheiro Cintra*, UFMG, Brasil Email: Lpcintra@gmail.comRenato Costa Braga, UFMG, Brasil Email: rhbra2020@gmail.comAllan Claudius Queiroz Barbosa, UFMG, Brasil Email: allan@ufmg.br Submetido: Fevereiro 2021Aceito: Junho 2021*Contato para Correspondência
TRENDS IN THE DEVELOPMENT OF ECOTOURISM: AN ANALYSIS OF THE LITERATURE AT A GLOBAL LEVEL | TENDÊNCIAS NO DESENVOLVIMENTO DO ECOTURISMO: UMA ANÁLISE DA LITERATURA
Authors: Franco Antonio Carlos , Franco Luciane Silva , Maganhotto Ronaldo Ferreira
Published: July 2024

Ecotourism is the appropriate activity for carrying out tourism in protected places, as it is concerned with environmental conservation, contributing to the development of local communities. The potential for ecotourism is significant due to national parks, wildlife sanctuaries, conservation reserves and community reserves, many of which include animal reserves. Therefore, this study aims to conduct a systematic review of the literature on high impact research on the evolution and trends related to ecotourism in the world context, in order to understand the different perspectives through critical analyzes, identifying gaps for future research and investigating trends in this body of literature. The results show the main developments and trends in the referred body of literature, possible relationship of ecotourism, as well as the main magazines that carried out studies on the topic and what are their results. The main countries that published high impact studies (JCR 2019) on the topics covered and number of citations can be consulted. In addition, this study provides an overview of ecotourism and the possibilities for future research. The development of studies on ecotourism must be related in terms of protected areas, natural resources and sustainable tourism. For future studies, it is considered important to investigate other impacts that influence Ecotourism, such as political, technological and legal. The study provides perspectives on ecotourism around the world in encouraging research in the sector. DOI: 10.18226/23190639.v9n3.04 Antônio Carlos Franco*, UTFPR, Brasil Email: francoancf@hotmail.comLuciane Silva Franco, UNICENTRO, Brasil Email: lu05-franco@hotmail.comRonaldo Ferreira Maganhotto, UNICENTRO, Brasil Email: rmaganhotto@unicentro.edu.br Submetido: Fevereiro 2021Aceito: Junho 2021*Contato para Correspondência
Actualización en vacunación contra la hepatitis B: situaciones especiales y nuevas vacunas. Revisión de tema
Authors: Castellanos Suaréz Rosendo , Saavedra González Karen Yurianny , Cadena Martínez Andrei Joseph
Published: July 2024

La vacuna ADN recombinante contra el virus de la hepatitis B es la vacuna estándar debido a su alta efectividad. Sin embargo, algunos pacientes tienen respuestas insuficientes. Este artículo busca describir la vacunación contra el virus de la hepatitis B en situaciones especiales y el desarrollo de nuevas vacunas. Se realizó una búsqueda en PubMed y ScienceDirect con términos como “Non-responsiveness”, “HIV”, “renal patients”, “dialysis patients”, “biological therapy” y “Hepatitis B vaccine”; se seleccionaron 41 artículos para revisión. En condiciones como infección por el virus de inmunodeficiencia humana, enfermedad renal crónica, terapia biológica y no respondedores, debido a factores genéticos, inmunológicos y variables individuales, existe un mayor riesgo de no generar anticuerpos suficientes para alcanzar un estado de inmunización adecuado. Actualmente, se han desarrollado nuevas vacunas (Fendrix®, Heplisav-B®, PreHevbrio®) que han mostrado tener mejores resultados, por lo que es necesario considerar una vacunación diferente a la estándar en situaciones especiales.
Variabilidad en los criterios de evaluación de trombofilia de médicos especialistas, en pacientes adultos con trombosis arterial: Colombia, septiembre 2021 a enero de 2022
Authors: Romero Camilo Andrés , Folleco Lucila Emilse , Pradilla Iván Felipe , Ramirez Natalia , Jaramillo Eugenia
Published: July 2024

Introducción: la trombofilia es un grupo de desórdenes sanguíneos, adquiridos o hereditarios, caracterizado por una predisposición a la formación de trombos venosos o arteriales. En la práctica clínica, hay variabilidad en los criterios de selección de pacientes a estudiar y en las pruebas de laboratorio a solicitar para trombofilia en trombosis arterial. Objetivo: describir los criterios de médicos especialistas colombianos para la evaluación de trombofilias en pacientes adultos con trombosis arterial y determinar la variabilidad de estos. Métodos: entre septiembre 2021 y enero 2022, mediante encuesta virtual a médicos especialistas en Colombia al cuidado de pacientes con trombosis arterial, se indagó sobre los criterios de selección de pacientes a estudiar y estudios a solicitar para trombofilias en casos de trombosis arterial. Los médicos encuestados fueron seleccionados por conveniencia, fueron contactados personalmente o vía correo electrónico. Resultados: 102 encuestas, se observaron 44 patrones de criterios de selección para estudio de trombofilias en casos de trombosis arterial (índice de variabilidad de 42,57 %). Los dos patrones más frecuentes incluían la historia familiar, la trombosis arterial recurrente, edad <50 años y la presencia de compromiso venoso. La variabilidad en las pruebas de laboratorio fue del 85,15 %. Los estudios más frecuentemente solicitados (>50 %) para el estudio de trombofilias en pacientes con trombosis arterial fueron anticuerpos anticardiolipinas (95,1 %), anticoagulante lúpico (95,1 %). Conclusión: existe variabilidad entre médicos especialistas colombianos al cuidado de pacientes adultos con trombosis arterial en los criterios de selección y pruebas de laboratorio a solicitar para el estudio de trombofilias.
Estimation of the spatial resolution of a synthetic aperture radar antenna of the VHF frequency range placed on board an unmanned aerial vehicle along a real flight path
Authors: Borisenkov Alexey V. , Goryachkin Oleg V. , Gusev Nikolay A. , Lifanov Alexey S.
Published: July 2024

Background. Currently, there is an intensive development of radar systems for remote sensing of the Earth, including those placed on unmanned aerial vehicles. Synthetic aperture radars are an effective means of round-the-clock and all-weather observation of objects on the Earth’s surface. Radars operating in the VHF range allow you to observe hidden and subsurface objects. The need for practical implementation of VHF band radar with synthesizing the aperture on board unmanned aerial vehicles requires additional research on the spatial resolution of radars, taking into account the unstable trajectory of the carrier.
Aim. The article considers the analysis of the influence of the flight path and its measurement errors on the quality of the radar image.
Methods. The research method provides an analysis of the shape of the radar uncertainty function with the synthesis of an aperture, which was built along a real trajectory using semi-natural mathematical modeling.
Results. As a result of the conducted research, it is shown that the quality of radar images is influenced not only by errors in the knowledge of motion parameters, but also by the very nature of the carrier’s movement and the duration of the flight.
Conclusion. Based on the results of field tests, it turned out to be possible to analyze these factors and determine the requirements for the UAV navigation system. Thus, the article shows the possibility of quality control of VHF band radar with synthesized aperture placed on board a UAV.
Modeling of electromagnetic wave reflection from wet soil taken into account of dispersion, heterogeneity and surface roughness
Authors: Panin Dmitry N. , Osipov Oleg V.
Published: July 2024

Background. Taking into account temperature, soil composition, surface roughness and the dependence of effective dielectric constant on frequency allows a more accurate assessment of soil moisture and other important parameters, which can be used in various fields such as agriculture, geology, ecology and hydrology.
Aim. In this work, we calculate the reflection of a linearly polarized electromagnetic wave from wet soil, taking into account such physical factors as heterogeneity of soil structure, surface roughness and dispersion.
Methods. Based on a heterogeneous mathematical model of wet soil, taking into account the dispersion of the dielectric constant of water and surface roughness, expressions are derived for the complex reflection coefficients of electromagnetic waves of vertical and horizontal polarization.
Results. The model of loose wet soil with the standard deviation of roughness on the surface was chosen as the object of study. An analysis of the frequency and angular characteristics of the modules of the reflection coefficients was carried out at a fixed level of soil moisture.
Conclusion. The data obtained as a result of the calculations is a valuable tool for further improving methods of remote sensing of the Earth and contributes to the development of new technologies for monitoring soil parameters using unmanned aerial vehicles, which opens up prospects for more accurate and efficient analysis of the state of land resources and ecosystems.
On-board equipment testing procedure for the effects of electrostatic discharges
Authors: Demidov Alexey A. , Piganov Mikhail N.
Published: July 2024

Background. The relevance of the topic of this work is due to the need to improve the reliability and quality of the assessment of the stability of the onboard electronic equipment of spacecraft to electrostatic discharges.
Aim. Investigation of the possibilities of using the electron flux in vacuum as a test effect on the spacecraft’s on-board radioelectronic equipment in assessing its resistance to electrostatic discharges.
Methods. Field experiment, research laboratory tests, modeling, mock-up, expert assessments. The article considers the conditions for the existence of an electronic stream in the «electronic spotlight» and «scanning» modes. A mock-up of an electronic device, which was previously used for testing in the atmosphere of air, was used as a test object. It has been structurally modified taking into account the dimensions, wiring diagram, tooling and electrophysical characteristics of the vacuum chamber. The modified layout is a first-level module with antennas located inside the housing. During the experiment, a vacuum meter, a kilovoltmeter, a digital oscilloscope with a bandwidth of 500 MHz, a high-voltage cable, a two-wire line, a hermetic plate, and an electron gun were used. The required vacuum was created using an automated pumping system.
Results. The conditions for the existence of an electron flow in a vacuum chamber with a pressure of up to 10–7 mm Hg have been experimentally established. The results of research tests of the radioelectronic module in the «electronic searchlight» and «scanning» modes have been obtained. The main types of interference from the action of electrostatic discharges are investigated. The analysis of the waveforms was carried out. Based on these results, a methodology has been developed for testing the onboard equipment of spacecraft for the effects of electrostatic discharges. The proposed method provides testing at a level of operating discharge current up to 30 µA with particle energy from 5 to 50 keV.
Conclusion. The test procedure and the means of its implementation comply with the basic requirements of GOST «Resistance to electrostatic discharges» and can be used for ground tests of spacecraft onboard equipment at four degrees of rigidity.
Coordinates estimation of the unmanned aerial vehicles by using distributed system of base stations
Authors: Tyurin Dmitry V. , Shishanov Sergei V. , Kazakov Vyacheslav V.
Published: July 2024

Background. The different sensors and global navigation satellite system are used for positioning unmanned aerial vehicles. But in case of short-term signal loss and increasing positioning accuracy, additional methods for estimating coordinates are used.
Aim. The paper deals with positioning methods for unmanned aerial vehicles based on range estimation to base stations.
Methods. The positioning methods were investigated by mathematical modeling in Uma scenario.
Results. The methods of coordinate estimation of unmanned aerial vehicles was analyzed. The accuracy of measurements and computational complexity in an urban scenario with different numbers of base stations were investigated by mathematical model.
Conclusion. The analysis shown that the standard deviation of the coordinate estimation is about 1 m.
Perceived Usefulness and Ease of Use of Gpt Technology in Enhancing Staff and Students Creativity in Management and Social Science
Authors: Oyetola Oyelakun  , Oluseyanu Olamide
Published: July 2024

The reality of education today includes addressing the digital transformation affecting universities and other educational institutions. This study investigates the relationship between generative pre-trained transformer (GPT) technology and the perceived enhancement of creativity among students and academic staff in the management and social science disciplines. Methodologically, the study adopted a survey research method with the aim of analyzing data collected from a statistically sampled 90 respondents from all departments within the Faculty of Management and Social Sciences. The responses collected were analyzed using partial least squares structural equation modeling. The results revealed a significant association between perceived usefulness, perceived ease of usage of GPT technology, and creativity. The study concluded that though the use of GPT technology enhances learning in that it helps to improve creativity in students and lecturers, its weak influence shows that it doesn’t have the monopoly of enhancing creativity in lecturers and students without other measures put in place to enhance creativity.
Lifestyle Identification and Random Blood Glucose Screening in Mulyorejo Public Health Center, Surabaya, Indonesia
Authors: Hariyono Hariyono , Madyawati Sri Pantja , Fauziyah Shifa , Sucipto Teguh Hari
Published: July 2024

Backgrounds: One of the non-communicable disease that still increase is Type 2 Diabetes Mellitus (T2DM). Of these, lifestyle pattern have been known as the risk factors. Objectives: This study aims to investigate lifestyle and conduct random blood glucose (RBG) screening in a community. Methods: Accidental sampling was conduct on November 12th to November 15th 2019 in Mulyorejo Public Health Center, Surabaya, Indonesia. Participants were investigate their lifestyle by self-questionnaire while RBG screening was done by using finger capillary test. Chi-square test was used to analyse the  relationship between lifestyle and level of RBG  Results:  The results shows that there’s no lifestyle variables that shows significantly associated with the level of RBG. Family history shows (p=0.15; p>0.05), blood pressure (p=0.91; p>0.05); smoking (p=0.26; p>0.05); physical activity (p=0.19; p>0.05); vegetable consumption (p=0.94; p>0.05); and fruit consumption (p=0.64; p>0.05). Conclusion: Self-questionnaire to identify lifestyle pattern and also random blood glucose screening is well method for preventive way as an early warning of T2DM. This screening must be conduct regularly, so that everyone known its risk factor.
Effect of Different Drying Methods on the Characteristics of Curcuma zedoaria rhizome
Authors: Dewi Aptika Oktaviana Trisna , Wakhid Ahmad Fatih Maulana , Yusup Rafli , Amalia Annora Rizky
Published: July 2024

Curcuma zedoaria is one of the plants that has the potential to be developed as raw material for making traditional medicine. The results of the study showed that white ginger has diverse pharmacological activities such as antihyperglycemia, antihyperlipids, antihypercholesterol, antiviral, anticancer / antitumor, immunomodulators, analgetics, anti-inflammatory, antipyretic and antioxidants. In the production process of traditional medicines, the quality of simplicia used as raw materials must meet quality standards in order to provide a good therapeutic effect. The quality of white intersection simplicia can be influenced by several factors, one of which is the drying method. The purpose of this study was to determine the effect of drying method on the characteristics of white intersection simplicia. The drying methods studied are drying direct sunlight, greenhouse drying, wind and oven. The characteristics tested are organoleptis test, microscopic test, water soluble juice test, ethanol soluble juice, water content, total ash content, acid insoluble ash content, microbial and fungal contamination. The results showed that the drying method can affect the characteristics of Curcuma zedoaria simplicia. The greenhouse drying method produces simplicia with the highest levels of ethanol marine essence and watersoluble essence, respectively 10.97±0.013% and 13.86±0.110%. The lowest water content of simplicia using a 50oC oven is 5.48%. The lowest total ash content was with the hybrid method, namely 7.006±0.018%.
Comparison of patients with chronic and episodic migraine with healthy individuals by brain volume and cognitive functions
Authors: Kamacı Şener Deniz , Zarifoğlu Mehmet , Hakyemez Bahattin , Karlı Necdet , Türkeş Nevin
Published: July 2024

Objectives: Migraine is a complex neurological disease. In addition to headache, individuals with migraine may develop structural changes inside the brain and cognitive impairment. There is increased evidence associated with impairments in brain volume and cognitive functions in patients with migraine. The present study aimed to investigate the impairment in memory function in individuals with migraine using brain magnetic resonance imaging, volume measurement, and neuropsychological tests.
Methods: The study included 20 patients with episodic migraine, 20 patients with chronic migraine, and 20 healthy controls. Subcortical volumes of all participants were measured by FreeSurfer, an automatic segmentation method. The Wechsler Memory Scale-Revised Form (WMS-R), Stroop test, Raven’s Standard Progressive Matrices, Verbal Fluency Test, and Lines Orientation Test were applied in all the study participants.
Results: Putamen volume decreased as migraine duration increased, and subcortical gray matter, left cerebellar cortex, and bilateral thalamus volumes were lower in the chronic and episodic group compared to the control group, bilateral putamen and right cerebellar cortex volumes were lower in patients with chronic migraine compared to patients in episodic migraine and control groups. Upon neuropsychological examination, delayed memory was affected as the duration of migraine increased, and there was impairment in patients with chronic migraine upon fluency tests and mental control tests.
Conclusions: Changes in subcortical volume and cognitive effects in patients with migraine raise questions about whether migraine qualifies as a benign disease. Structural changes and cognitive impairment may contribute to migraine-associated disability, and therefore, these causalities should be investigated by future studies. Silent infarcts, white matter damage, and cortical spreading depression, which occur in migraine cases, may be associated with subcortical volume changes and thus, cognitive effects. In the context, studies with larger samples to achieve a better understanding are needed.
EVALUASI PEMBERIAN PROBIOTIK BIOMOL(+) TERHADAP ORGAN TUBUH NON KARKAS AYAM BROILER
Authors: Makmur Ali , Samadi Samadi , Ridhana Fita , Ayuti Siti Rani
Published: July 2024

Penelitian ini bertujuan untuk mengetahui pengaruh penambahan probiotik komersial (Biomol+) dalam pakan terhadap berat non-karkas ayam pedaging. Sebanyak 200 ekor anak ayam pedaging umur satu hari dibeli dari breeder lokal, ditempatkan secara acak ke dalam 20 unit kandang (1 x 1 m) yang masing-masing berisi 10 ekor anak ayam. Setiap kandang dilengkapi dengan sebuah tempat pakan, tempat minum, dan serbuk gergaji sebagai alas lantai. Percobaan dilakukan selama 35 hari berdasarkan Rancangan Acak Lengkap dengan empat perlakuan pakan dan lima kali ulangan. Semua kelompok ayam diberi pakan komersial sebagai pakan basal dan disuplementasi dengan atau tanpa Biomol(+) sesuai dengan perlakuan berikut: P0, kelompok kontrol, diberi pakan komersial sebagai pakan basal, sedangkan P1, P2, dan P3 adalah pakan basal yang disuplementasi Biomol(+) pada level masing-masing 0,15%, 0,30%, dan 0,45%. Pada akhir periode percobaan, satu ayam dipilih dari tiap kelompok dan disembelih untuk pengukuran berat non-karkas. Hasil penelitian menunjukkan bahwa sebagian besar persentase non-karkas tidak dipengaruhi oleh level penambahan Biomol (+). Persentase usus halus, usus besar, paru-paru, hati, ampela, pankreas, dan lemak abdominal tidak berbeda di antara kelompok perlakuan. Hanya persentase berat jantung yang diamati meningkat secara signifikan pada level Biomol(+) yang lebih tinggi dibandingkan dengan kelompok kontrol. Sebagai kesimpulan, penambahan Biomol(+) dalam pakan ayam pedaging, tidak menunjukkan efek negatif pada kondisi non-karkas selama periode percobaan. Dengan mempertimbangkan parameter kinerja lainnya, penelitian ini menunjukkan bahwa Biomol(+) sebagai produk probiotik memiliki potensi sebagai agen pemacu pertumbuhan dalam sistem pemeliharaan ayam pedaging.
NILAI KECERNAAN IN VITRO SILASE CAMPURAN RUMPUT KUME (Sorghum plumosum var. Timorense) DAN DAUN GAMAL (Gliricidiasepium) DENGAN LEVEL BERBEDA
Authors: Ndun Alberth Nugrahadi , Mulik Simon Edison , Nifu Salden Eliazar
Published: July 2024

ujuan penelitian ini untuk mengetahui nilai kecernaan silase campuran rumput Kume dan daun gamal secara in vitro. Rancangan percobaan yang digunakan dalam penelitian ini adalah Rancangan Acak Lengkap, yang terdiri dari 4 perlakuan dan 3 ulangan. Perlakuan yang dimaksud adalah : R0 = rumput Kume 60% : daun Gamal 40% ; R1 = rumput Kume 70% : daun Gamal 30% ; R2 = rumput Kume 80% : daun Gamal 20% ; R3 = rumput kume 90% : daun Gamal 10%, masing-masing perlakuan ditambahkan gula air 3%, sebagai pengawet. Parameter yang diamati dalam penelitian ini yakni nilai kecernaan bahan kering, kecernaan bahan organik, dan Bahan Ekstrak Tanpa Nitrogen (BETN). Hasil penelitian menunjukkan nilai kecernaan bahan kering semakin meningkat seiring bertambahnya level daun Gamal dari nilai 58,66% (R3) hingga 63,00% (R0). Bertambahnya level daun Gamal juga menyebabkan kecernaan bahan organik meningkat, 61,34% (R3) menjadi 64,34% (R0). Bertambahnya level daun Gamal, juga mampu menurunkan BETN dari 40,67% pada R3 menjadi 40,33% pada R0. Dapat disimpulkan bahwa penambahan daun Gamal dalam campuran silase rumput Kume meningkatkan kecernaan bahan kering, dan bahan organik namun menurunkan BETN.
PENGARUH PEMBERIAN PUPUK KANDANG BERBEDA TERHADAP PERTUMBUHAN DAN PRODUKSI RUMPUT SETARIA (Setaria sphacelata) PADA PEMOTONGAN PERTAMA
Authors: Rahayu Sri , Subagyo Djoko , Murdani Khairul
Published: July 2024

Penelitian ini bertujuan melihat pengaruh pemberian pupuk kandang berbeda terhadap pertumbuhan dan produksi rumput Setaria (Setaria sphacelata) pada pemotongan pertama. Penelitian ini dilaksanakan berdasarkan Rancangan Acak Kelompok (RAK) dengan empat perlakuan dan tiga kelompok. Pelakuan jenis pupuk kandang yang diberikan masing-masing: P0: tanpa pupuk kandang (kontrol), P1: 300 g feses ayam, P2: 300 feses sapi, dan P3: 300 g feses kambing. Parameter yang diamati adalah tinggi tanaman, jumlah anakan, produksi segar dan produksi kering. Hasil penelitian menunjukkan bahwa pemberian pupuk dari feses ayam, sapi dan kambing, nyata meningkatkan tinggi tanaman, jumlah anakan, produksi berat segar dan berta kering rumput jika dibandingkan dengan kontrol, akan tetapi ditemukan adanya perbedaan yang diamati diantara kelompok rumput yang mendapatkan jenis pupuk kandang berbeda.
EXPERIENCE IN THE TREATMENT OF PATIENTS WITH DIVERTICULAR COLON FISTULAS
Authors: KARPUKHIN OLEG Yu. ,   Kazan State Medical University, SHAKIROV RAIS R. , PANKRATOVA YULIA S. , ZIGANSHIN MARAT I. , SHAKUROV AIDAR F. ,   Kazan State Medical University,   Kazan State Medical University,   Republican Clinical Hospital, Kazan,   Kazan State Medical University
Published: July 2024

Abstract. Introduction. In the 21st century, a massive increase was noted in the incidence of diverticular disease (DD) by more than 10 times with an increase in the frequency of its complications ranging from 5 to 25%. According to the literature, the colon fistulation frequency is 5-30%, over a half of such formations being colovesical fistulas. The problem of surgical approaches to the purulent-inflammatory complications of DD is far from being resolved. Despite the fact that diverticular disease is a benign pathology, inflammatory process often creates serious technical difficulties in surgery due to the violation of the anatomical relationship of the intestine with the surrounding organs, while surgeries often affect several organs with a high infection risk. Aim. Analysis of the results of the treatment of patients with diverticular colon fistulas in a specialized department of a multidisciplinary hospital. Materials and Methods. Treatment outcomes were analyzed retrospectively in 347 patients with diverticular colon disease complications for the period from 2013 to 2022. The study included 17 patients with diverticular fistulas: 14 (82.4%) patients with internal (intestinal-urinary (13) and intestinal-vaginal (1)) fistulas and 3 (17.6%) with external ones. Results and Discussion. The therapeutic and diagnostic algorithm for diverticular fistulas required a wide range of diagnostic methods and a multidisciplinary approach. Surgery remains the single treatment option for this pathology. The choice of the surgical procedure depended on the inflammatory process severity, its spread to the surrounding abdominal organs, and the largest diverticula accumulation in the gut. In the group of patients with intestinal-urinary fistulas, the resection was not limited to the removal of the colon segment only. In 9 (52.9%) cases, it was expanded to the anterior rectum resection due to the inflammation transition to its upper ampullary region. We are supporters of the one-stage surgical procedures with forming the primary anastomosis in patients with diverticular fistulas. We give preference to the Sigal-Ramazanov invagination anastomosis that allows avoiding the anastomosis due to creating a duplicate of the intestinal wall hiding the anastomosis zone. The paper identifies probable predictors of complicating diverticular disease with fistulation. Conclusions. Choosing the optimal treatment option for patients with diverticular disease complications is a difficult problem. It is better to operate on them in the coloproctology departments of multidisciplinary hospitals with the established good interaction among the members of a multidisciplinary team.
EARLY DIAGNOSIS OF LATE-ONSET BRONCHIAL ASTHMA IN COMORBID PATIENTS
Authors: POSTNIKOVA LARISA B. ,   City Clinical Hospital No. 38, Nizhny Novgorod
Published: July 2024

Abstract. Introduction. Underdiagnosis of late-onset bronchial asthma and improvement of methods for its early detection is an important trend in medicine, which is associated with the increasing number of adult patients with variable respiratory symptoms, allergologic history, and comorbid background. It seems reasonable to improve the early diagnosis of late-onset asthma in comorbid patients using screening scales. Aim. To assess the risk of late-onset bronchial asthma in comorbid patients, using the Adult Epidemiologic Asthma Scale (A2) and the European Community Respiratory Health Survey (ECRHS) questionnaire. Material and Methods. Eighty patients aged 59.9±11.6 (–51.3% of them being female patients) were examined. Group 1: Comorbid patients with the established asthma; group 2: Comorbid patients without asthma. Asthma risk factors, respiratory symptoms, frequency of comorbid conditions, and blood eosinophil count were evaluated. Additionally, questionnaires including A2 and ECRHS scales were used in asthma screening. The diagnostic significance of questionnaires for early detection of late-onset asthma was assessed using ROC analysis. Results and Discussion: The patients examined were comparable in age, sex, and adherence to smoking. Over 63% of the group 1 patients had hereditary history of asthma and sensitization to allergens in contrast to the group 2 patients (0%). Patients in both groups frequently reported choking (group 1: 100%, group 2: 85.1%), cough (100% and 57.4%, respectively), and wheezing (69.7% and 38.3%, respectively). Among comorbidities, the frequency of which was comparable between the groups (p>0.05), arterial hypertension (group 1: 66.7%, group 2: 59.6%) and obesity (60.6% and 42.6%, respectively) were predominant. Over 35% of patients in each group had chronic heart failure. There was a trend toward more frequent development of diabetes mellitus in patients with asthma (30.3% and 12.8%; p=0.054). The sum of A2 and ECRHS scale scores exceeded 4 in all patients with asthma. In group 2, “Probable asthma” was reported by 46.8% of patients in the A2 questionnaire and by 27.7% on the ECRHS scale. According to ROC-analysis, “Probable asthma” in the group 2 patients on A2 scale was recorded at the sum of scores > 6 (100% sensitivity and 82.9% specificity) and > 4 scores (87.8% sensitivity and 87.2% specificity) for ECRHS questionnaire. Conclusions. High diagnostic value of A2 and ECRHS questionnaires was determined in comorbid patients with respiratory symptoms without asthma. In 30% of cases, the questionnaire results established “Probable asthma” in this category of patients.
ROLE OF GUT MICROBIOTA AND SELECTED METABOLIC PRODUCTS IN THE DEVELOPMENT OF CHILDHOOD OBESITY
Authors: SKVORTSOVA OLGA V. ,   Samara State Medical University, MIGACHEVA NATALIA B. , KAGANOVA TATIANA I. , LYAMIN ARTEM V. , ANTIPOV VLADIMIR A. ,   Samara State Medical University,   Samara State Medical University,   Samara State Medical University,   Samara State Medical University
Published: July 2024

Abstract. Introduction. Obesity is one of the major problems in pediatrics worldwide. In recent years, the role of the gut microbiota in the development of various pathological conditions, including childhood obesity and its complications, has been increasingly discussed. We have presented the data characterizing changes in the gut microbiota in overweight patients and discussed their potential role in the development of this disease. Aim. To consider the key points of forming the intestinal microbiota in the neonatal period and the relationship of this process with the development of obesity in the subsequent years of the child’s life, the peculiarities of the microbiological landscape in obese patients, and the functional role of individual metabolites in its formation. Materials and Methods. A review of the scientific literature in the biomedical publication databases, such as PubMed, Medline, eLibrary, Google Scholar, and the Cochrane Library. Results and Discussion. Gut microbiota interact symbiotically with the human body, influencing metabolic activity and physiological characteristics. The microbiota formed at an early age are the basis of general health, but unfavorable influences on the processes of formation of the infant’s intestinal microbiota, such as non-physiological birth, artificial feeding, treatment with antibacterial drugs, can lead to the formation of pathological conditions. Metabolic processes in obese patients are particularly affected by qualitative changes in the intestinal microbiota and impaired synthesis of short-chain fatty acids. Excessive quantities of short-chain fatty acids produced by specific members of the gut microbiota represent an additional energy source and could lead to an energy imbalance, contributing to the development of obesity. Conclusions. Individual members of the gut microbiota can also be considered as predictors of obesity complications. Essential short-chain fatty acids are only a small part of the wide range of metabolites produced by gut bacteria, which also exert their influence on the metabolic and immune homeostasis of the human body.
Representasi Budaya dan Profil Pelajar Pancasila di Buku Pelajaran Bahasa Indonesia Kelas VII
Authors: Puspitasari Alfi , Andayani Andayani , Setyoningsih Titi
Published: July 2024

This study aims to (1) describe the representation of culture in Indonesian textbooks grade VII, (2) describe the representation of Pancasila student profile in Indonesian textbooks grade VII. This research is a qualitative research and uses case study method with content analysis approach. The data source of this research is the seventh grade Indonesian textbook. The sampling technique was done by purposive sampling. Data collection was done by document analysis. The data validity test technique used was data source triangulation. The results of this study are, in the seventh grade Indonesian textbooks, cultural representations are found to be described through Koentjaraningrat's cultural elements in the form of language, technological systems, livelihood systems, social organization, knowledge systems, religious systems, and arts. Second, in the seventh grade Indonesian textbook, there is a representation of the Pancasila student profile which is divided into six dimensions, namely faith, fear of God Almighty; and noble character; global diversity; mutual cooperation; independent; critical reasoning; and creative. In the discussion, the six dimensions are then further divided based on the existing key elements
Pemanfaatan Laman Let’s Read Kategori Cerita Rakyat sebagai Media Pembelajaran Inovatif BIPA Keterampilan Membaca
Authors: Afrani Aurora , Suyatno Suyatno , Mulyono Mulyono
Published: July 2024

The era of digitalization has caused learning activities to be increasingly integrated with technology. This is based on the many learning pages that can support learning objectives, one of which is the Let's Read page. This page can be used as a BIPA learning medium because the characteristics of the reading in it are appropriate to the level of knowledge of BIPA students. This research aims to analyze three forms of use of the Let's Read page in the folklore category as an innovative BIPA learning medium for reading skills. The three forms referred to are as a means of mastering vocabulary, a source of innovative reading, a means of introducing Indonesian culture and literature. The method used in this research is descriptive qualitative. This research data is in the form of sentences from interviews with BIPA students as well as the results of researchers' analysis of the Let's Read page. Data collection was carried out through interviews and observations. The research results show that the Let's Read page in the folklore category can be used as an innovative BIPA learning medium for reading skills.
Analisis Teks pada Buku Pelajaran Bahasa Indonesia Kelas X Terbitan Kemdikbud Edisi Revisi Tahun 2017
Authors: Numertayasa I Wayan , Selamet Kumara Priantara I Komang Gede
Published: July 2024

This study aims to conduct a text analysis on Indonesian language textbooks in Grade X by focusing on (1) Language Use in Indonesian Language Textbooks in Grade X, (2) Conformity of Indonesian Language Textbooks in Grade X to the 2013 Curriculum, (3) Conformity of Indonesian Language Textbook Discourse to Strengthening Character Education for Grade X Students, (4) Impact of Indonesian Language Textbooks on Learning for Grade X Students. The method in this research is descriptive qualitative research method with critical discourse analysis approach. The subject of this research is the Indonesian Language textbook Grade X for SMA/SMK, published by the Ministry of Education and Culture in the 2017 revised edition. The results showed that from (1) language use, (2) conformity with the 2013 curriculum, (3) conformity of discourse with strengthening character education, (4) the impact of textbooks on student learning is included in the good category, feasible, and in accordance with the level of understanding of students. In accordance with these findings, it is expected that the government and teachers should work together to develop and improve the quality of Indonesian language learning books to make them more interesting in accordance with the times, relevant, easy for students to understand