bluuebunny/crossref_metadata_2025 huggingface dataset:
Ponad filologią i lingwistyką stosowaną. Polonistyka
stosowana jako integrująca koncepcja badawcza
Authors: Gębal Przemysław E.
Published: January 2022

Applied Polish studies are a currently developed research area and university
teaching practice combining the traditional philological Polish studies with
other scientifi c disciplines based on inter- and transdisciplinary academic
collaboration principles to meet the needs arising from the performance of
tasks assigned to specifi c professions requiring a background in Polish studies
in the fi eld of linguistic, literary and cultural studies. Originally developed by
Stanisław Dubisz, the concept became a stimulus for establishing the Institute
of Applied Polish Studies at the University of Warsaw and similar units at other
Polish universities. This text shows the potential of a continued support for the
development of applied Polish studies as an integrative research concept and
associates it with the concepts of the Polish applied linguistics and applied
languages studied at Western European universities.
Parenteza a metatekst
Authors: Żabowska Magdalena
Published: January 2022

This paper discusses the question of correlations between the terms
‘parenthesis’ and ‘metatext’. To this end, it presents the most signifi cant
(syntactic and functional) concepts of parenthesis and issues related to the
metatextuality of parenthetical structures. Apart from overview sections,
the paper puts forward the author’s own proposition for distinguishing the
scope of the term ‘parenthesis’ from that of ‘metatext’ (‘parentheticality’ vs
‘metatextuality’, respectively). It assumes that the essence of parenthesis, unlike
metatextuality, is not to comment on the expressions used currently; instead,
it is an effect of the speaker’s actions performed on the present statement
(cf. the opposition: language tools and actions using such tools). The paper
presents also organisation of language expressions (both individual units
and entire classes) by their capability to occur in parenthesis (cf. inherently
parenthetical elements of the system vs parenthetical usages of language
expressions) and fulfi l metatextual functions. It also takes up the question of
the infl uence of parenthetical structures on changes in language: with reference
to the development of metatextual expressions and their classes as a result of
lexicalisation and grammaticalisation processes.
O wyrażeniach w miarę i na miarę. Rozważania na marginesie opisów
słownikowych
Authors: Kisiel Anna
Published: January 2022

The presented paper takes up a debate with the existing (mainly dictionary)
descriptions of expressions assuming the form w miarę and na miarę. It shows
that, although the intuition of the authors of the descriptions is often right,
the descriptions themselves are not suffi ciently precise. What is pointed to as
a potential source of the misunderstandings is the multitude of the types of
usage of the base noun miara. Based on a description of syntactic requirements,
connectivity (including frequent collocations), and meanings, three units
assuming the form w miarę (a gradation operator and two prepositions) and two
units assuming the form na miarę (a preposition and an attributive expression)
are distinguished. At the same time, it is noticed that the attributive (adverbial
and adjectival) usages are the least established in terms of syntax and the most
controversial ones.
Minimizing Travel Time and Latency in Multi-Capacity Ride-Sharing Problems
Authors: Luo Kelin , Spieksma Frits C. R.
Published: January 2022

Motivated by applications in ride-sharing and truck-delivery, we study the problem of matching a number of requests and assigning them to cars. A number of cars are given, each of which consists of a location and a speed, and a number of requests are given, each of which consists of a pick-up location and a drop-off location. Serving a request means that a car must first visit the pick-up location of the request and then visit the drop-off location. Each car can only serve at most c requests. Each assignment can yield multiple different serving routes and corresponding serving times, and our goal was to serve the maximum number of requests with the minimum travel time (called CSsum) and to serve the maximum number of requests with the minimum total latency (called CSlat). In addition, we studied the special case where the pick-up and drop-off locations of a request coincide. Both problems CSsum and CSlat are APX-hard when c≥2. We propose an algorithm, called the transportation algorithm (TA), which is a (2c−1)-approximation (resp. c-approximation) algorithm for CSsum (resp. CSlat); these bounds are shown to be tight. We also considered the special case where each car serves exactly two requests, i.e., c=2. In addition to the TA, we investigated another algorithm, called the match-and-assign algorithm (MA). Moreover, we call the algorithm that outputs the best of the two solutions found by the TA and MA the CA. We show that the CA is a two-approximation (resp. 5/3) for CSsum (resp. CSlat), and these ratios are better than the ratios of the individual algorithms, the TA and MA.
Does Digestate Dose Affect Fodder Security and Nutritive Value?
Authors: Kolackova Ivana , Smolkova Barbora , Latal Oldrich , Skalickova Sylvie , Skladanka Jiri , Horky Pavel , Knot Pavel , Hammerschmiedt Tereza , Kintl Antonin , Holatko Jiri , Pozdisek Jan , Brtnicky Martin
Published: January 2022

With the rising interest in digestate use as a fertilizer on permanent cultures, there is a need to examine its effects on food and feed quality. This study is focused on the use of digestate in grassland fertilization and its effects on nutritive value parameters such as mycotoxin contamination (deoxynivalenol, aflatoxin, and T-2 toxin) and nutrient content (crude protein, crude fat, crude fiber, ash, nitrogen-free extract, digestibility of organic matter, acid detergent fiber, and ash-free neutral detergent fiber). The experiment was carried out in the Czech Republic, and the effects of fertilization regime, year, and harvest date (summer and fall cuts) on nutritive value were observed. An effect of the year on DON, AFB1, and T-2 contamination levels was observed. An effect of the harvest or fertilization regime on mycotoxin contamination was not observed. Significant differences were observed in the content of all nutrients, except ash, depending on the year. Differences were found only in the case of ADF levels, depending on the harvest date, as well; however, no differences were found between fertilization regimes. Our findings suggest that digestate does not negatively affect fodder in terms of nutritive value nor safety.
Application of PGPB Combined with Variable N Doses Affects Growth, Yield-Related Traits, N-Fertilizer Efficiency and Nutritional Status of Lettuce Grown under Controlled Condition
Authors: Consentino Beppe Benedetto , Aprile Simona , Rouphael Youssef , Ntatsi Georgia , De Pasquale Claudio , Iapichino Giovanni , Alibrandi Pasquale , Sabatino Leo
Published: January 2022

Nitrogen (N) fertilization is a crucial agricultural practice for boosting production traits in vegetables. However, N synthetic fertilizers—commonly adopted by farmers—have several counterproductive effects on the environment and on humans. The research was performed to assess the combined influence of plant growth promoting bacteria (PGPB) (Azospirillum brasilense DSM 1690, A. brasilense DSM 2298 and Pseudomonas sp. DSM 25356) and various N fertilization doses (0, 30, 60 or 120 kg ha−1) on growth, yield, quality and nitrogen indices of lettuce in protected cultivation. Plant height, root collar diameter, number of leaves and fresh weight were enhanced by A. brasilense DSM 2298 inoculation and N at 30 or 60 kg ha−1. Overall, soluble solids content (SSC), ascorbic acid, total phenolics, carotenoids, total chlorophyll and total sugars were augmented by the combined effect of A. brasilense strains and 30, 60 or 120 kg N ha−1. Furthermore, PGBP inoculation improved potassium (K) and magnesium (Mg) concentrations in leaf tissues. PGPB inoculation increased N leaf concentration; however, it hastened N indices. These results suggest that the PGPB tested can be considered an eco-friendly tool to improve lettuce yield, particularly when combined with N at 30 or 60 kg ha−1.
Modelling the Relative Abundance of Roe Deer (Capreolus capreolus L.) along a Climate and Land-Use Gradient
Authors: Benjamin Caryl S. , Uphus Lars , Lüpke Marvin , Rojas-Botero Sandra , Dhillon Maninder Singh , Englmeier Jana , Fricke Ute , Ganuza Cristina , Haensel Maria , Redlich Sarah , Riebl Rebekka , Tobisch Cynthia , Uhler Johannes , Zhang Jie , Menzel Annette , Peters Wibke
Published: January 2022

European roe deer (Capreolus capreolus L.) are important given their economic, recreational and ecological value. However, uncontrolled roe deer numbers can result in negative impacts on forest regeneration and agricultural crops, disease transmission and occurrences of deer-vehicle collisions. Information on the abundance and distribution is needed for effective management. We combined distance sampling (DS) of roe deer dung pellet groups with multiple variables to develop a density surface model (DSM) in the federal state of Bavaria in south-eastern Germany. We used the estimates of pellet group density as a proxy for roe deer relative abundance. We extrapolated our best DSM, conducted a quantitative evaluation and contrasted relative abundance along climate and land-use gradients. Relative abundance of roe deer was influenced by a combination of habitat type, climate and wildlife management variables, which differed between seasons and which reflected changes in food and shelter availability. At the landscape scale, the highest abundance was observed in agriculture-dominated areas and the lowest in urban areas. Higher abundance was also observed in areas with intermediate temperatures compared to the warmest areas. Our results provide information on possible future changes in the distribution of relative abundance due to changes in climate and land-use.
A Review and Analysis of the National Dog Population Management Program in Chile
Authors: Garde Elena , Marín-Vial Paula , Pérez Guillermo E. , Sandvig Erik M.
Published: January 2022

Free-roaming dogs are a worldwide problem, with Chile having some of the highest human-to-dog ratios in the world. In 2017, Law 21.020 was promulgated and the federal government developed a national responsible pet ownership program. The objectives of this article are to describe and discuss the dog-related components of the program, to design a tool for determining human-to-dog ratios in Chile, and to make recommendations to managers to improve the program outcomes. The overarching goal of the program was to mitigate the conflict between humans and dogs, but many of the interventions were animal-focused and the indicators did not consider the perception of the Chilean public. Using human density data and known dog populations, we found that as the human density increased, there were fewer dogs per person. Veterinary services and sterilizations were the mainstay of the program and were offered for free to citizens. Education was offered to all ages through public events, as well as municipality and organization activities. The identification of dogs was obligatory for dog owners. Enforcement was not included in the program. The recommendations are to conduct preintervention baseline data collections and to tailor interventions and indicators appropriately; to use dog population size estimates determined at the local level rather than a country-wide estimate; to replace free veterinary services with low-cost sterilization campaigns; to create sustainable plans for education; and to create enforcement teams in communities.
Effect of Diet Composition on Excreta Composition and Ammonia Emissions from Growing-Finishing Pigs
Authors: Le Dinh Phung , van der Peet-Schwering Carola , Ogink Nico , Aarnink André
Published: January 2022

This study aimed to investigate the impact of decreased crude protein (CP) levels (by 2% units) or acidifying diets (by adding 10 g benzoic acid/kg diet in combination with replacing a part of CaCO3 by about 10 g Ca-formate/kg diet) on urine, feces and manure composition and ammonia emissions from growing and finishing pig houses. Yorkshire x F1(Landrace x Yorkshire) pigs (n = 576) with an initial body weight of 24.9 ± 3.4 kg were randomly allocated to four treatments of (i) a control diet with normal protein content and no acidifying components added; (ii) a diet with 2% units CP reduction; (iii) a diet with an acidifying effect on the manure; (iv) or a diet consisting of a combination of diet (ii) and (iii). Pigs were housed in four mechanically ventilated and temperature-controlled rooms. Results showed that decreasing the dietary CP levels by 2% units reduced the ammonia emission from the floor by 46% (p = 0.06) and from the pig house by 31% (p = 0.08). Decreased CP diets reduced the total N in feces and in manure and NH4-N in the manure, as well as the ammonia concentration at 1 cm and 10 cm above the manure surface (p < 0.05). However, acidifying diets failed to reduce ammonia emissions from the floor and the pig house (p > 0.05). Reducing dietary crude protein is, therefore, a solution to reducing ammonia emissions from pig houses.
Efficacy of Tigecycline as Salvage Therapy in Multidrug-Resistant Febrile Neutropenia in Patients with Acute Leukemia—A Single Center Analysis
Authors: Modemann Franziska , Härterich Steffen , Schulze zur Wiesch Julian , Rohde Holger , Lindeman Nick Benjamin , Bokemeyer Carsten , Fiedler Walter , Ghandili Susanne
Published: January 2022

Severe infectious complications remain the main cause of mortality in leukemia patients due to a long period of profound neutropenia. Standardized regimens for antimicrobial, antifungal, and antiviral prophylaxis and therapy in neutropenic patients have improved infection-associated mortality. Nevertheless, many patients are refractory to these multidrug approaches. Tigecycline is a last-resort antibiotic with a broad-spectrum activity; unfortunately, clinical experience in multidrug-resistant febrile neutropenia is limited. The aim was to evaluate the efficacy of tigecycline treatment in comparison to standard treatment in this patient cohort. In this single center analysis, we analyzed the clinical courses of 73 patients with acute leukemia and diagnosis of febrile neutropenia resistant to hospital-based multidrug escalation levels who continued on a standard approach without antibiotics as the last resort (n = 30) or were switched to tigecycline in addition to carbapenem treatment (n = 43). We observed comparable overall response rates (decrease in C-reactive protein or resolution of fever) in both patient cohorts. Switching the antibiotic approach to tigecycline showed lower absolute sepsis (33% vs. 47%, p = 0.235) and infection-associated mortality rates (5% vs. 13%, p = 0.221). Prospective larger randomized studies are necessary to underline these results and to be able to generate reliable statistics.
Evaluation of Dietary Probiotic Bacteria and Processed Yeast (GroPro-Aqua) as the Alternative of Antibiotics in Juvenile Olive Flounder Paralichthys olivaceus
Authors: Choi Wonsuk , Moniruzzaman Mohammad , Bae Jinho , Hamidoghli Ali , Lee Seunghan , Choi Youn-Hee , Min Taesun , Bai Sungchul C.
Published: January 2022

We investigated the three probiotic bacteria and a processed yeast (GroPro-Aqua) as the replacers of antibiotics in juvenile olive flounder. A total of seven diets were used, that is, one basal or control (CON) diet; and six other diets, of which, three diets were prepared by supplementing probiotic bacteria such as Bacillus subtilis WB60 (BSWB60) at 1 × 108 CFU/g diet, Bacillus subtilis SJ10 (BSSJ10) at 1 × 108 CFU/g diet, and Enterococcus faecium SH30 (EFSH30) at 1 × 107 CFU/g diet; one diet with processed yeast (GRO) at 0.35% diet; and two other diets were supplemented with oxytetracycline (OTC) and amoxicillin (AMO) at 4 g/kg of each. Triplicate groups of fish (average 12.1 g) were fed one of the diets for eight weeks. At the end of the feeding trial, the fish that were fed the probiotic bacteria-supplemented diets had a significantly higher final weight, weight gain, and specific growth rate compared to the CON, OTC, and AMO diets. Fish that were fed the GRO diet had significantly higher feed efficiency and protein efficiency ratios than those of the fish that were fed the CON diet. Serum glutamic pyruvic transaminase, glutamic oxaloacetic transaminase, glucose, and total protein were not affected by the diets. Lysozyme activity in fish that were fed the BSSJ10, BSWB60, and EFSH30 diets were significantly higher compared to the CON and OTC diets, whereas myeloperoxidase activity of fish fed the BSWB60 and EFSH30 diets were significantly higher than those of fish fed the CON and AMO diets. Flounder growth hormone gene expressions of fish that were fed BSWB60 and GRO diets were significantly higher compared to the CON, OTC, and AMO diets. The interleukin-1β gene expression of fish that were fed the BSSJ10, BSWB60, EFSH30, OTC, and GRO diets was significantly higher than those of fish fed the CON diet. The interleukin-10 gene expression of fish that were fed the BSSJ10, EFSH30, and GRO diets was significantly higher than those of fish fed the CON and AMO diets. Posterior intestinal histology of fish showed significantly higher villi length in fish that were fed the BSSJ10, BSWB60, EFSH30, and GRO diets compared to the CON diet. After 15 days of challenge test with pathogenic bacteria Edwardsiella tarda, the cumulative survival rate of fish that were fed the BSSJ10, BSWB60, EFSH30, and GRO diets were significantly higher than those of fish that were fed the CON diet. Overall, the results indicate that dietary supplementation of B. subtilis (108 CFU/g diet), E. faecium (107 CFU/g diet), and processed yeast (GroPro-Aqua at 0.35% diet) could replace the antibiotics in terms of improving growth, immunity, gut health, and disease resistance in juvenile olive flounder.
Oxidized Forms of Ergothioneine Are Substrates for Mammalian Thioredoxin Reductase
Authors: Jenny Kaelyn A. , Mose Gracyn , Haupt Daniel J. , Hondal Robert J.
Published: January 2022

Ergothioneine (EGT) is a sulfur-containing amino acid analog that is biosynthesized in fungi and bacteria, accumulated in plants, and ingested by humans where it is concentrated in tissues under oxidative stress. While the physiological function of EGT is not yet fully understood, EGT is a potent antioxidant in vitro. Here we report that oxidized forms of EGT, EGT-disulfide (ESSE) and 5-oxo-EGT, can be reduced by the selenoenzyme mammalian thioredoxin reductase (Sec-TrxR). ESSE and 5-oxo-EGT are formed upon reaction with biologically relevant reactive oxygen species. We found that glutathione reductase (GR) can reduce ESSE, but only with the aid of glutathione (GSH). The reduction of ESSE by TrxR was found to be selenium dependent, with non-selenium-containing TrxR enzymes having little or no ability to reduce ESSE. In comparing the reduction of ESSE by Sec-TrxR in the presence of thioredoxin to that of GR/GSH, we find that the glutathione system is 10-fold more efficient, but Sec-TrxR has the advantage of being able to reduce both ESSE and 5-oxo-EGT directly. This represents the first discovered direct enzymatic recycling system for oxidized forms of EGT. Based on our in vitro results, the thioredoxin system may be important for EGT redox biology and requires further in vivo investigation.
Antioxidant Properties of Pulp, Peel and Seeds of Phlegrean Mandarin (Citrus reticulata Blanco) at Different Stages of Fruit Ripening
Authors: Costanzo Giulia , Vitale Ermenegilda , Iesce Maria Rosaria , Naviglio Daniele , Amoresano Angela , Fontanarosa Carolina , Spinelli Michele , Ciaravolo Martina , Arena Carmen
Published: January 2022

In this work, we assess the potential of waste products of Phlegrean mandarin (Citrus reticulata Blanco), namely seeds and peel, to be reutilized as a source of bioactive compounds beneficial for the human diet. Starting from the evidence that the by-products of this specific cultivar are the most powerful sources of antioxidants compared to pulp, we have investigated if and how the bioactive compounds in peel and seeds may be affected by fruit ripening. Three stages of fruit ripening have been considered in our study: unripe fruits = UF, semi-ripe fruits = SRF, ripe fruits = RF. The overall results indicated that RF showed the highest concentration of antioxidants. Among fruit components, peel was the richest in total antioxidant capacity, total polyphenol content, total flavonoids, total chlorophylls and carotenoids, while seeds exhibited the highest concentration of total condensed tannins and ascorbic acid. The liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay indicates the occurrence, in peel extracts, of 28 phenolic compounds, mainly flavonoids (FLs); in seeds, 34 derivatives were present in the first stage (UF), which diminish to 24 during the ripening process. Our data indicated that the content of phytochemicals in citrus strongly varies among the fruit components and depends on the ripening stage. The higher antioxidant activity of peel and seeds, especially in RF, encourage a potential use of by-products of this specific citrus cultivar for industrial or pharmacological applications. However, to maximize the occurrence of desired bioactive compounds, it is important also to consider the ripening stage at which fruits must be collected.
Process Technology for Development and Performance Improvement of Medical Radiation Shield Made of Eco-Friendly Oyster Shell Powder
Authors: Kim Seon-Chil
Published: January 2022

As radiation-based techniques become increasingly important tools for medical diagnostics, medical professionals face increasing risk from the long-term effects of scattered radiation exposure. Although existing radiation-shielding products used in medicine are traditionally lead-based, recently, the development of more eco-friendly materials such as tungsten, bismuth, and barium sulfate has drawn attention. However, lead continues to be superior to the proposed alternative materials in terms of shielding efficiency and cost effectiveness. This study explores the feasibility of radiation shielding materials based on the shells of bivalve mollusks such as oysters that are discarded from aquaculture, thereby preventing them from going into landfills. In addition, a firing process for enhancing the shielding efficiency of the original material is proposed. Experiments show that shielding sheets comprising 0.3 mm thick layers of oyster shell achieve a shielding efficiency of 37.32% for the low-energy X-rays typically encountered in medical institutions. In addition, the shielding efficiency was improved by increasing the density of the powdered oyster shell via plastic working at 1200 °C. This raises the possibility of developing multi-material radiation shields and highlights a new potential avenue for recycling aquaculture waste.
Characteristics of 2.45 GHz Surface-Wave-Sustained Argon Discharge for Bio-Medical Applications
Authors: Benova Evgenia , Marinova Plamena , Tafradjiiska-Hadjiolova Radka , Sabit Zafer , Bakalov Dimitar , Valchev Nikolay , Traikov Lubomir , Hikov Todor , Tsonev Ivan , Bogdanov Todor
Published: January 2022

Cold atmospheric plasma (CAP) applications in various fields, such as biology, medicine and agriculture, have significantly grown during recent years. Many new types of plasma sources operating at atmospheric pressure in open air were developed. In order to use such plasmas for the treatment of biological systems, plasma properties should fulfil strong requirements. One of the most important is the prevention from heating damage. That is why in many cases, the post-discharge region is used for treatment, but the short living particles in the active discharge zone and reactions with them are missed in that case. We use the active region of surface-wave-sustained argon plasma for biological systems treatment. The previous investigations showed good bactericidal, virucidal, seeds germination and decontamination effects at a short treatment time, but the discharge conditions for bio-medical applications need specific adjustment. A detailed theoretical and experimental investigation of the plasma characteristics and their possible optimization in order to meet the requirements for bio-medical applications are presented in this paper. The length of the plasma torch, the temperature at the treatment sample position and the microwave radiation there are estimated and optimized by the appropriate choice of discharge tube size, argon flow rate and microwave power.
Special Issue on the Histopathology of Aquatic Animals
Authors: Rašković Božidar , Berillis Panagiotis
Published: January 2022

Histopathology is the study of changes in any tissue associated with a disease or disorder [...]
Quinine Charge Transfer Complexes with 2,3-Dichloro-5,6-Dicyano-Benzoquinone and 7,7,8,8-Tetracyanoquinodimethane: Spectroscopic Characterization and Theoretical Study
Authors: Mostafa Gamal A. E. , Yousef Tarek A. , Gaballah Samir T. , Homoda Atef M. , Al-Salahi Rashad , Aljohar Haya I. , AlRabiah Haitham
Published: January 2022

The molecular charge transfer reactions of quinine (Q) with 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) and 7,7,8,8-tetracyanoquinodimethane (TCNQ) as a π-acceptor to form charge transfer (CT) complexes have been studied. The CT complexes were characterized by infrared spectra, NMR, mass spectrometry, conductometry and spectrometry. The Q-DDQ and Q-TCNQ charge transfer complexes were monitored at 480 and 843 nm, respectively. The results confirm the formation of CT complexes. The molar ratio of Q:DDQ and Q: TCNQ assessed using Job’s method was 1:1, which agrees with the results obtained by the Benesi-Hildebrand equation. The stability of the formed CT complexes was assessed by measuring different spectroscopic parameters such as oscillator strength, transition dipole moment, ionization potential, the energy of CT complex, resonance energy, dissociation energy and standard free energy change. The DFT geometry optimization of quinine, DDQ and TCNQ, its charge transfer complex, and UV theoretical vs. experimental comparative study were carried out. The theoretical and experimental results agreed. DFT/B3LYP/6-311++G(d,p) level of theory was used for the investigation of charge transfer between quinine as electron donor and (DDQ and TNCQ) as electron acceptors. The geometric structures, orbital energies, HOMO, LUMO and energy gaps were determined. The transition energies of the charge transfer complexes were computed using the TD-DFT/B3LYP/6-311++G(d,p) level of theory. The computed parameters were comparable to the experimental parameters, and the computational results aided in the analysis of the data.
The Origin and Physico-Chemical Properties of Some Unusual Earth Rock Fragments
Authors: Cocean Alexandru , Postolachi Cristina , Cocean Georgiana , Bulai Georgiana , Munteanu Bogdanel Silvestru , Cimpoesu Nicanor , Cocean Iuliana , Gurlui Silviu
Published: January 2022

In this paper, several researches were undertaken related to a violent phenomenon, characterized by a sonic boom, felt on an area of at least 500 km2, shortly followed by the fall of rock fragments that were then recovered from the ground. These presented different appearance characteristics from those of the materials and rocks specific to the respective area. Spectroscopic and petrographic analyses were performed to identify the composition, morphological and crystallinity characteristics in order to elucidate the nature of the collected rock samples. Using FTIR spectroscopy functional groups, as those reported in the literature for Murchison, Bells and Allende, carbonaceous chondrite meteorites were identified. The fragments evidenced topography and morphology that can be assigned to the chondrules and chondrites of carbonaceous meteorites (CMs). The material in the fragments proved to be as insoluble organic material (IOM), being insoluble in water and organic solvents. Its crystalline structure was also evidenced by XRD analysis and FTIR spectrum. These physico-chemical properties, in relation to the sonic boom perceived in the area from where they were collected, indicate the spatial origin of the fragments of rock as possible meteorite fragments.
Capturing a Space Target Using a Flexible Space Robot
Authors: Liu Xiao-Feng , Zhang Xiao-Yu , Cai Guo-Ping , Chen Wu-Jun
Published: January 2022

Capturing space targets by space robots is significant for on-orbit service and is a challenging research topic nowadays. This paper focuses on the dynamics and control of capturing a non-cooperative space target by a space robot with a long flexible manipulator. Firstly, the dynamic equation of the flexible space robot is given. The Hertz contact model is used to describe the contact force between the robot and the target. Secondly, an active compliance controller is designed to reduce the capture impact on the robot. Finally, the capture impact on the whole system is analyzed in detail in four scenarios: the combination of two kinds of movement forms and two kinds of relative positions of the robot and the target before capturing. Simulation results indicate that the capturing operation may cause complicated dynamic behaviors such as the vibration of elastic links and the continuous collision of the target. Moreover, the results show that the control method effectively offsets the capture impact on the space robot system. In general, this work lays a theoretical foundation for further study of the dynamic phenomena of the capture process.
Analyzing Dynamic Operational Conditions of Limb Prosthetic Sockets with a Mechatronics-Twin Framework
Authors: Chen Dejiu , Su Peng , Ottikkutti Suranjan , Vartholomeos Panagiotis , Tahmasebi Kaveh Nazem , Karamousadakis Michalis
Published: January 2022

Lower limb prostheses offer a solution to restore the ambulation and self-esteem of amputees. One key component is the prosthetic socket that serves as the interface between prosthetic device and amputee stump and thereby has a wide range of impacts on efficient fitting, appropriate load transmission, operational stability, and control. For the design and optimization of a prosthetic socket, an understanding of the actual intra-socket operational conditions becomes therefore necessary. This is however a difficult task due to the inherent complexity and restricted observability of socket operation. In this study, an innovative mechatronics-twin framework that integrates advanced biomechanical models and simulations with physical prototyping and dynamic operation testing for effective exploration of operational behaviors of prosthetic sockets with amputees is proposed. Within this framework, a specific Stewart manipulator is developed to enable dynamic operation testing, in particular for a well-managed generation of dynamic intra-socket loads and behaviors that are otherwise difficult to observe or realize with the real amputees. A combination of deep learning and Bayesian Inference algorithms is then employed for analyzing the intra-socket load conditions and revealing possible anomalous.
Development of an Ergonomic Writing Assistive Device for Finger Pain Reduction in the Elderly
Authors: Kim Sol , Jung Ji-Yong , Yang Chang-Min , Lee Yeon-Kyun , Kim Jung-Ja
Published: January 2022

The decreased muscle mass and increased prevalence of musculoskeletal diseases in the elderly means that this population often experiences difficulty with writing. Although various commercial writing assistive devices exist to reduce pain and improve writing efficiency, low satisfaction with their design prevents them from being widely adopted. In this study, we developed a new ergonomic writing assistive device that overcomes these shortcomings and reduces finger pain. Twenty elderly people with normal writing skills participated in a performance evaluation of our designed device. We used two commercial writing assistive devices and the developed writing assistive device to write a given experimental sentence three times each for each device. For each device, finger-related muscles activity and finger pressure were measured during the experiment, and satisfaction level was evaluated using the modified QUEST 2.0 after the experiment. As a result, the activity in abductor pollicis brevis (18.16%) and first dorsal interosseous muscle (14.17%) was significantly higher when using the NDWAD (newly developed writing assistive device) than when using commercialized WADs (writing assistive devices) (p < 0.05). Finger pressure in the thumb (0.59 N), index finger (1.09 N), and middle finger (0.46 N) was significantly lower when using NDWAD than when using WADs (p < 0.05). The satisfaction level of NDWAD (4.47) was higher than that of WADs. Therefore, we confirmed that our design reduced finger pressure and improved user satisfaction. Consequently, the NDWAD developed in this study can be used as a writing aid not only for the elderly, but also for patients with writing disabilities.
Making Sense of Light: The Use of Optical Spectroscopy Techniques in Plant Sciences and Agriculture
Authors: Cavaco Ana M. , Utkin Andrei B. , Marques da Silva Jorge , Guerra Rui
Published: January 2022

As a result of the development of non-invasive optical spectroscopy, the number of prospective technologies of plant monitoring is growing. Being implemented in devices with different functions and hardware, these technologies are increasingly using the most advanced data processing algorithms, including machine learning and more available computing power each time. Optical spectroscopy is widely used to evaluate plant tissues, diagnose crops, and study the response of plants to biotic and abiotic stress. Spectral methods can also assist in remote and non-invasive assessment of the physiology of photosynthetic biofilms and the impact of plant species on biodiversity and ecosystem stability. The emergence of high-throughput technologies for plant phenotyping and the accompanying need for methods for rapid and non-contact assessment of plant productivity has generated renewed interest in the application of optical spectroscopy in fundamental plant sciences and agriculture. In this perspective paper, starting with a brief overview of the scientific and technological backgrounds of optical spectroscopy and current mainstream techniques and applications, we foresee the future development of this family of optical spectroscopic methodologies.
Prediction of Arsenic Removal from Contaminated Water Using Artificial Neural Network Model
Authors: Al-Yaari Mohammed , Aldhyani Theyazn H. H. , Rushd Sayeed
Published: January 2022

Arsenic is a deleterious heavy metal that is usually removed from polluted water based on adsorption processes. The latest mode of modeling such a process is to implement artificial intelligence (AI). In the current work, a new artificial neural network (ANN) model was developed to predict the adsorption efficiency of arsenate (As(III)) from contaminated water by analyzing different architectures of an adaptive network-based fuzzy inference system (ANFIS). The database for the current study consisted of the experimental data of the adsorption of As(III) by different adsorbents/biosorbents. The data were randomly divided into two sets: 70% for the training phase and 30% for the testing phase. Four statistical evaluation metrics, namely, mean square error (MSE), root-mean-square error (RMSE), Pearson’s correlation coefficient (R%), and the determination coefficient (R2) were used for the analysis. The best performing ANFIS model was characterized with the average values of 97.72%, 0.9333, 0.137, and 0.274 of R%, R2, MSE, and RMSE, respectively. In addition, a parametric investigation revealed that the most dominating parameters on the adsorption process efficiency were in the following order: pH, As initial concentration, contact time, adsorbent dosage, inoculum size, and temperature. The results of the current study would be useful in the adsorption process scale-up and optimization.
Improved Protoporphyrin IX-Guided Neurosurgical Tumor Detection with Frequency-Domain Fluorescence Lifetime Imaging
Authors: Reichert David , Erkkilae Mikael T. , Gesperger Johanna , Wadiura Lisa I. , Lang Alexandra , Roetzer-Pejrimovsky Thomas , Woehrer Adelheid , Wilzbach Marco , Hauger Christoph , Drexler Wolfgang , Kiesel Barbara , Widhalm Georg , Leitgeb Rainer A. , Unterhuber Angelika , Andreana Marco
Published: January 2022

Precise intraoperative brain tumor visualization supports surgeons in achieving maximal safe resection. In this sense, improved prognosis in patients with high-grade gliomas undergoing protoporphyrin IX fluorescence-guided surgery has been demonstrated. Phase fluorescence lifetime imaging in the frequency-domain has shown promise to distinguish weak protoporphyrin IX fluorescence from competing endogenous tissue fluorophores, thus allowing for brain tumor detection with high sensitivity. In this work, we show that this technique can be further improved by minimizing the crosstalk of autofluorescence signal contributions when only detecting the fluorescence emission above 615 nm. Combining fluorescence lifetime and spectroscopic measurements on a set of 130 ex vivo brain tumor specimens (14 low- and 56 high-grade gliomas, 39 meningiomas and 21 metastases) coherently substantiated the resulting increase of the fluorescence lifetime with respect to the detection band employed in previous work. This is of major interest for obtaining a clear-cut distinction from the autofluorescence background of the physiological brain. In particular, the median fluorescence lifetime of low- and high-grade glioma specimens lacking visual fluorescence during surgical resection was increased from 4.7 ns to 5.4 ns and 2.9 ns to 3.3 ns, respectively. While more data are needed to create statistical evidence, the coherence of what was observed throughout all tumor groups emphasized that this optimization should be taken into account for future studies.
Phytoaccumulation of Heavy Metals by Sodom Apple (Calotropis procera (Aiton) W. T. Aiton) along an Urban–Rural Gradient
Authors: Siraj  , Khan Nasrullah , Ali Kishwar , Khan Muhammad Ezaz Hasan , Jones David Aaron
Published: January 2022

Heavy metals (HMs) are widely recognized for their toxicity and have serious environmental implications as technology advances and public pressure mounts to guarantee the safest and healthiest environment. This study evaluates the phytoremediation potential of HMs i.e., Copper (Cu), Zinc (Zn), Lead (Pb), and Cadmium (Cd) by Calotropis procera (Aiton) W.T. Aiton, also known as Sodom apple, along an urban–rural gradient and its effect on communities’ diversity, forage and medicinal quality in semi-arid region of Khyber Pakhtunkhwa Pakistan. The HM concentration was investigated along with the urban–rural gradients by sampling C. procera and soil samples. Acid-digested samples were tested for metal concentration using an atomic absorption spectrophotometer (AAS). We used principal component analysis and cluster analysis to identify the pattern of metal distribution in plants and soil. To comprehend the species’ diversity of plant communities in polluted sites, the species’ composition of C. procera communities was explored. Our results showed that the concentration of HMs in the soil and plant decreased from Zn to Cd (Zn > Cu > Pb > Cd). Likewise, more than half of the soil metal accumulated in the roots and aerial part of the plant, indicating the bioaccumulation potential of the plant species for these metals. Zn, Cu, Pb, and Cd translocation ratio varied from root > stem > leaf > flower. Root to stem transfer of metal was poor, but strongly mobilized to the leaves when available in the stems. Carthamus lanatus, Sonchus asper, Cynodon dactylon, Xanthium strumarium, and Silybum marianum were the leading species in three groups of 36 plant species. Pearson’s correlation revealed a significant relationship between HM concentrations and diversity indices. Zn and Cu content in the soil influenced plant species richness, Shannon–Wiener index (H′), and evenness index (Eh). Given the environmental toxicity of HMs, Cd concentrations in soil exceeded the permissible level, suggesting residents should be warned about potential health risks. As a result, the species chosen for this study can be employed as a biomonitor and phytoremediator of soil contaminated by these HMs, as it can accumulate HMs to a toxic level.
The Reliability of Contralateral Suppression of Otoacoustic Emissions Is Greater in Women than in Men
Authors: Jedrzejczak W. Wiktor , Pilka Edyta , Pastucha Malgorzata , Kochanek Krzysztof , Skarzynski Henryk
Published: January 2022

The aim of this study was to compare the reliability of the medial olivocochlear reflex (MOCR) between men and women. The strength of the MOCR was measured in terms of the suppression of transiently evoked otoacoustic emissions (TEOAEs) by contralateral acoustic stimulation (CAS). The difference between TEOAEs with and without CAS (white noise) was calculated as raw decibel TEOAE suppression as well as normalized TEOAE suppression expressed in percent. In each subject, sets of measurements were performed twice. Reliability was evaluated by calculating the intraclass correlation coefficient, the standard error of measurement, and the minimum detectable change (MDC). The study included 40 normally hearing subjects (20 men; 20 women). The estimates of MOCR for both genders were similar. Nevertheless, the reliability of the MOCR was poorer in men, with an MDC around twice that of women. This can be only partially attributed to slightly lower signal-to-noise ratios (SNRs) in men, since we used strict procedures calling for high SNRs (around 20 dB on average). Furthermore, even when we compared subgroups with similar SNRs, there was still lower MOCR reliability in men.
Approximate Flow Friction Factor: Estimation of the Accuracy Using Sobol’s Quasi-Random Sampling
Authors: Praks Pavel , Brkić Dejan
Published: January 2022

The unknown friction factor from the implicit Colebrook equation cannot be expressed explicitly in an analytical way, and therefore to simplify the calculation, many explicit approximations can be used instead. The accuracy of such approximations should be evaluated only throughout the domain of interest in engineering practice where the number of test points can be chosen in many different ways, using uniform, quasi-uniform, random, and quasi-random patterns. To avoid picking points with undetected errors, a sufficient minimal number of such points should be chosen, and they should be distributed using proper patterns. A properly chosen pattern can minimize the required number of testing points that are sufficient to detect maximums of the error. The ability of the Sobol quasi-random vs. random distribution of testing points to capture the maximal relative error using a sufficiently small number of samples is evaluated. Sobol testing points that are quasi-randomly distributed can cover the domain of interest more evenly, avoiding large gaps. Sobol sequences are quasi-random and are always the same, which allows the exact repetition of scientific results.
Redox Homeostasis and Immune Alterations in Coronavirus Disease-19
Authors: Bellanti Francesco , Lo Buglio Aurelio , Vendemiale Gianluigi
Published: January 2022

The global Coronavirus Disease 2019 (COVID-19) pandemic is characterized by a wide variety of clinical features, from no or moderate symptoms to severe illness. COVID-19 is caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that first affects the respiratory tract. Other than being limited to lungs, SARS-CoV-2 may lead to a multisystem disease that can even be durable (long COVID). The clinical spectrum of COVID-19 depends on variability in the immune regulation. Indeed, disease progression is consequent to failure in the immune regulation, characterized by an intensification of the pro-inflammatory response. Disturbance of systemic and organ-related redox balance may be a further mechanism underlying variability in COVID-19 severity. Other than being determinant for SARS-CoV-2 entry and fusion to the host cell, reactive species and redox signaling are deeply involved in the immune response. This review sums up the present knowledge on the role of redox balance in the regulation of susceptibility to SARS-CoV-2 infection and related immune response, debating the effectiveness of antioxidant compounds in the management of COVID-19.
Approaches to Visualising Endocytosis of LDL-Related Lipoproteins
Authors: Siddiqui Halima , Yevstigneyev Nikita , Madani Golnoush , McCormick Sally
Published: January 2022

Endocytosis is the process by which molecules are actively transported into cells. It can take on a variety of forms depending on the cellular machinery involved ranging from specific receptor-mediated endocytosis to the less selective and actin-driven macropinocytosis. The plasma lipoproteins, which deliver lipids and other cargo to cells, have been intensely studied with respect to their endocytic uptake. One of the first molecules to be visualised undergoing endocytosis via a receptor-mediated, clathrin-dependent pathway was low-density lipoprotein (LDL). The LDL molecule has subsequently been shown to be internalised through multiple endocytic pathways. Dissecting the pathways of lipoprotein endocytosis has been crucial to understanding the regulation of plasma lipid levels and how lipids enter cells in the arterial wall to promote atherosclerosis. It has also aided understanding of the dysregulation that occurs in plasma lipid levels when molecules involved in uptake are defective, as is the case in familial hypercholesterolemia (FH). The aim of this review is to outline the many endocytic pathways utilised for lipoprotein uptake. It explores the various experimental approaches that have been applied to visualise lipoprotein endocytosis with an emphasis on LDL and its more complex counterpart, lipoprotein(a) [Lp(a)]. Finally, we look at new developments in lipoprotein visualisation that hold promise for scrutinising endocytic pathways to finer detail in the future.