bluuebunny/crossref_metadata_2025 huggingface dataset:
Understanding K. phaffii ( Pichia pastoris ) Host Cell Proteins: Proteomic Analysis and Flow-through Affinity Clearance
Authors: Sripada Sobhana Alekhya , Elhanafi Driss , Collins Leonard , Williams Taufika Islam , Linova Marina , Woodley John , Menegatti Stefano
Published: February 2023

K. phaffii is a versatile expression system that is increasingly
utilized to produce biological therapeutics – including enzymes,
engineered antibodies, and gene-editing tools – that feature multiple
subunits and complex post-translational modifications. Two major
roadblocks limit the adoption of K. phaffii in industrial
biomanufacturing: its proteome, while known, has not been linked to
downstream process operations and detailed knowledge is missing on
problematic host cell proteins (HCPs) that endanger patient safety or
product stability; furthermore, the purification toolbox has not evolved
beyond the capture of monospecific antibodies, and few solutions are
available for engineered antibody fragments and other protein
therapeutics. To unlock the potential of yeast-based biopharmaceutical
manufacturing, this study presents (i) a secretome survey of
K. phaffii cell culture harvests that highlights HCPs with
predicted immunogenicity, ability to cause product instability by
proteolysis or degradation of excipients, and potential to interfere
with purification operations via product association or co-elution; and
(ii) a novel affinity adsorbent functionalized with peptide
ligands that target the whole spectrum of K. phaffii HCPs –
PichiaGuard – designed for the enrichment of therapeutic proteins in
flow-through mode. The PichiaGuard adsorbent features high HCP binding
capacity (~25 g per liter of resin) and successfully
purified a monoclonal antibody and an ScFv fragment from clarified
K. phaffii harvests, affording up to 80% product yield, and a
>300-fold removal of HCPs. Notably, PichiaGuard
outperformed commercial ion exchange and mixed-mode resins in removing
high-risk HCPs – including aspartic proteases, ribosomal subunits, and
other peptidases – thus demonstrating its value in modern
biopharmaceutical processing.
G protein-coupled receptor modulation of striatal dopamine transmission: Implications for substance use disorders
Authors: Littlepage-Saunders Mydirah , Hochstein Michael , Chang Doris , Johnson Kari
Published: February 2023

Dopamine transmission in the striatum is a critical mediator of the
rewarding and reinforcing effects of commonly misused psychoactive
drugs. G protein-coupled receptors (GPCRs) that bind a variety of
neuromodulators including dopamine, endocannabinoids, acetylcholine, and
endogenous opioid peptides regulate dopamine release by acting on
several components of dopaminergic circuitry. Striatal dopamine release
can be driven by both somatic action potential firing and local
mechanisms that depend on acetylcholine released from striatal
cholinergic interneurons. GPCRs that primarily regulate somatic firing
of dopamine neurons via direct effects or modulation of synaptic inputs
are likely to impact distinct aspects of behavior and psychoactive drug
actions compared with GPCRs that primarily regulate local
acetylcholine-dependent dopamine release in striatal regions. This
review will highlight mechanisms by which GPCRs modulate dopaminergic
transmission and the relevance of these findings to psychoactive drugs
involved in substance use disorders.
NAMPT INHIBITION AND INCREASED NAD-BIOAVAILABILITY ATENUATE LIVER DAMAGE IN CCl4-INDUCED MICE LIVER FIBROSIS
Authors: Suarez-Cuenca Juan , Buendia Ariel Gutierrez , Vaca Rebeca Pérez-Cabeza de , Vera-Gómez Eduardo , Domínguez-Pérez Gabriela , Hernández-Patricio Alejandro , Vega-Moreno Karen De la , Salamanca-García Moisés , Coral-Vázquez Ramón , Toledo-Lozano Christian , García Silvia , Mondragón-Terán Paul , Hernández-Muñóz Rolondo
Published: February 2023

Background and Purpose: Nicotinamide phosphoribosyltransferase (NAMPT)
is the rate-limiting enzyme within the NAD+ salvage biosynthetic pathway
and also a cytokine modulator with effects on inflammation and
fibrogenesis. FK866 (NAMPT inhibitor) has shown anti-inflammatory
properties. However, FK866-induced depletion of NAD+ may also impair
liver bioenergetic metabolism during Chronic Liver Disease (CLD). The
aim of this study was to evaluate the effects of NAMPT inhibition and
NAD+ restoration on experimental CLD. Experimental Approach.
CCl4-induced liver cirrhosis was established after 6 weeks. Treatment
groups (n=5 mice per group) included: 1) vehicle; 2) CCl4 control; 3)
Silymarin + CCl4; 4) FK866 + CCl4; and 5) NMN+FK866+CCl4. At the end of
the experimental induction and treatments, mice were sacrificed and
liver was collected for weight, and paraformaldehyde fixed for
histological characteristics of inflammation and fibrosis, as well as
NAD+/NADH determination by colorimetric assay. Liver function tests were
performed from blood sample. Statistical analysis was performed by
T-test. Key Results. NAMPT inhibition resulted in a mild attenuation of
histological and biochemical features of the CCl4-induced liver damage.
NAD+ restoration, by the concomitant administration of its precursor
NMN, resulted in a significant improvement of the histological
characteristics; evidenced by a lower inflammatory infiltrate and
fibrosis as well as lower levels of bilirubin. NAMPT inhibition and
adequate NAD+ restoration were confirmed by a colorimetric assay of NADH
and NAD+ and biochemical features were measured by routinary Liver
Function Tests. Conclusion and implications. This study shows that NAMPT
inhibition concomitant to NAD restoration significantly attenuate
experimental liver damage.
Island partitioning of smart distribution systems in emergency situations considering voltage and frequency stability
Authors: Najafabadi Zahra Hosseini , Foroud Asghar Akbari
Published: February 2023

Island partitioning is a solution to restore service in smart
distribution systems after the disconnection of the main grid due to
faults. A two-stage and multi-objective solution is presented to restore
the services of the island system. At first stage, the proposed
partitioning scheme is presented with regards to the available time to
decide on control measures, considering the voltage stability and the
priority and controllability of the loads in the load shedding, and
considering the frequency response and the voltage stability margin in
finding the borders of the partitions. In the second stage, optimal
power flow is done to set the partitions and satisfy the system
operational constraints. The results show the proposed method not only
leads to the creation of partitions with the allowable bus voltage and
frequency but also leads to the lowest losses, the largest amount of
restored load, and supplying loads with the highest values. Moreover,
proposed method is more comprehensive due to considering voltage
stability, frequency stability, occurrence of simultaneous faults,
existence of controllable and uncontrollable distributed generation,
power reserve, controllability of loads and DGs, position of switches,
maximum time available to make decisions about control measures and the
time delay between control measures
ANTI-LIPOMA POTENTIAL OF FRESH PALM FRUITS EXTRACT
Authors: Okorie Uchechukwu , Uro-Chukwu Henry Chukwuemeka , Eleazu Chinedum Ogbonnaya
Published: February 2023

ANTI-LIPOMA POTENTIAL OF FRESH PALM FRUITS EXTRACT 3Okorie Uchechukwu,
1,2Uro-Chukwu Henry Chukwuemeka, 3Eleazu Chinedum Ogbonna 1National
Obstetric Fistula Centre, Abakaliki, Ebonyi State, Nigeria 2Institute
for Nutrition, Nutraceutical & Public Health Research & Development,
Nigeria, 3Department of Biochemistry, Alex-Ekwueme Federal University
Ndufu Alike, Abakaliki, Ebonyi State, Nigeria *Corresponding author:
uchechukwuc20022yahoo.com Abstract Antilipoma potential of fresh palm
fruit extract was observed on three subjects who gave their consents.
The individuals involved did topical application of the fresh crude palm
fruits oil extract on the spots of the lipoma on their body between two
to six months leading to the disappearance of the lipoma. There is no
recurrence after two years. Although a follow-up is still on-going for
the next five years. Keywords: anti-lipoma, liposuction, palm fruits,
lipoma
Testing the Generalization of Neural Language Models for COVID-19 Misinformation Detection
Authors: Wahle Jan Philip , Ashok Nischal , Ruas Terry , Meuschke Norman , Ghosal Tirthankar , Gipp Bela
Published: February 2023

A drastic rise in potentially life-threatening misinformation has been a
by-product of the COVID-19 pandemic. Computational support to identify
false information within the massive body of data on the topic is
crucial to prevent harm. Researchers proposed many methods for flagging
online misinformation related to COVID-19. However, these methods
predominantly target specific content types (e.g., news) or platforms
(e.g., Twitter). The methods’ capabilities to generalize were largely
unclear so far. We evaluate fifteen Transformer-based models on five
COVID-19 misinformation datasets that include social media posts, news
articles, and scientific papers to fill this gap. We show tokenizers and
models tailored to COVID-19 data do not provide a significant advantage
over general-purpose ones. Our study provides a realistic assessment of
models for detecting COVID-19 misinformation. We expect that evaluating
a broad spectrum of datasets and models will benefit future research in
developing misinformation detection systems.
Analysis of Marine Heatwaves in the Bay of Bengal region
Authors: Kumar Sudhanshu , Chakraborty Arun
Published: February 2023

In the ocean, temperature extremes have adverse effects on precipitation
patterns, sea level change, and migration/damage of ecosystems. It has
been found that most species are more sensitive to extreme events like
marine heatwaves (MHWs), implying the severe impacts of MHWs on ecology.
These events are driven by various atmospheric and oceanic processes. In
recent years, these extreme events are more frequent and intense
globally and their increasing trend is expected to continue in the
upcoming decades. They have the potential to devastate marine habitats,
and ecosystems together with ensuing socioeconomic consequences. It
recently attracted public interest and scientific researchers, which
motivates us to analyze the recent MHW events in the Bay of Bengal
region. we have isolated 107 MHW events (above the 90th percentile
threshold) in this region of the Indian Ocean and investigated the
variation in duration, intensity, and frequency of MHW events during our
test period (1982-2021). Our study reveals that the average of three MHW
events per year in the study region with an increasing linear trend of
1.11 MHW events per decade. In the analysis, we found the most intense
event has a maximum intensity was 5.29°C (above the climatology mean),
while the mean intensity was 2.03°C. In addition, we observed net heat
flux accompanied by anticyclonic eddies to be the primary cause of these
events. Also, an effort has been made to understand the relationship
between climate modes, sea surface height, and the difference between
evaporation and precipitation with the occurrence of MHW events.
Calibrated absolute seafloor pressure measurements for geodesy in Cascadia
Authors: Cook Matthew James , Frederickson Erik K , Roland Emily Carlson , Sasagawa Glenn S. , Schmidt David , Wilcock William S. D. , Zumberge Mark Andrew
Published: February 2023

The boundary between the overriding and subducting plates is
locked along some portions of the Cascadia subduction zone. The extent
and location of locking affects the potential size and frequency of
great earthquakes in the region. Because much of the boundary is
offshore, measurements on land are incapable of completely defining a
locked zone in the up-dip region. Deformation models indicate that a
record of seafloor height changes on the accretionary prism can reveal
the extent of locking. To detect such changes, we have initiated a
series of calibrated pressure measurements using an absolute
self-calibrating pressure recorder (ASCPR). A piston-gauge calibrator
under careful metrological considerations produces an absolutely known
reference pressure to correct seafloor pressure observations to an
absolute value. We report an accuracy of about 25 ppm of the water
depth, or 0.02 kPa (0.2 cm equivalent) at 100 m to 0.8 kPa (8 cm
equivalent) at 3,000 m. These campaign survey-style absolute pressure
measurements on seven offshore benchmarks in a line extending 100 km
westward from Newport, Oregon from 2014 to 2017 establish a long-term,
sensor-independent time series that can, over decades, reveal the extent
of vertical deformation and thus the extent of plate locking and place
initial limits on rates of subsidence or uplift. Continued surveys
spanning years could serve as calibration values for co-located or
nearby continuous pressure records and provide useful information on
possible crustal deformation rates, while epoch measurements spanning
decades would provide further limits and additional insights on
deformation.
Thermomagnetic recording stability of taenite-containing meteoritic cloudy zones
Authors: Devienne José Augusto , Berndt Thomas Andreas , Williams Wyn , Nagy Lesleis
Published: February 2023

The cloudy zone (CZ), a nm-sized intergrowth of taenite or tetrataenite
crystals (or islands), is the most promising phase to preserve
palaeomagnetic records in (stony-)iron meteorites. While slowly-cooled
meteorites form tetrataenite – an extremely good recorder –
fast-cooled meteorites contain fine-grained taenite islands, which were
considered unsuitable for palaeomagnetic studies. In this work, however,
we show that nm-sized taenite grains are stable over billion-year
timescales, indicating that taenite-bearing meteorites are reliable
sources of paleomagnetic information. Additionally, we find a range of
sizes for which taenite forms stable single-domain structures.
Single-domain states might be preserved even through subsequent
tetrataenite ordering, implying that tetrataenite might carry
magnetization state inherited from its precursor taenite. This remanent
magnetization can be up to 10\textsuperscript{5} years
older than that of larger tetrataenite islands in the same meteorite,
which would have been reset upon ordering. This allow studding to two
distinct events of planetesimal formation from a single sample.
Scale-dependent Air-Sea Mechanical Coupling: Resolution Mismatch and Spurious Eddy-Killing
Authors: Rai Shikhar , Hecht Matthew W. , Maltrud Mathew E , Aluie Hussein
Published: February 2023

Mechanical coupling of the atmosphere to the ocean surface in general
circulation models is represented using bulk wind stress formulations.
The stress is often based on either absolute wind velocity, τa, or the
more correct wind velocity relative to the ocean surface currents, τr.
Here, we use coarse-graining to disentangle wind work by these
formulations at different length-scales. We show that both can be
reasonably accurate in forcing the ocean at length-scales larger than
the mesoscales, with τa overestimating wind work by 10%. However, τa
and τr show stark and opposing systematic biases in how they drive the
mesoscales; τa does negligible (albeit positive) work on the mesoscales,
while τr yields eddy-killing (negative work) that is artificially
exaggerated by a factor of ≈4. We derive an analytical criterion for
eddy-killing to occur, which shows that exaggerated eddy killing is due
to resolution mismatch between the atmosphere and ocean. Our criterion
highlights the disproportionate effect small-scale winds Ο(100)km can
have on the dynamics of mesoscale ocean eddies, despite the dominant
atmospheric motions being at length-scales larger than Ο(103) km. The
eddy-killing criterion shows that large-scale winds do not necessarily
cause eddy-killing but are merely an amplification factor for wind work
on the mesoscales, which can be either positive or negative depending on
the local alignment of small-scale winds with the ocean eddies. We
propose a simple reformulation of τr, without introducing tuning
parameters, to remove spurious eddy-killing from air-sea resolution
mismatch that is often present in climate models.
Existence and uniqueness of solutions to some classes of nonlocal semilinear conformable fractional differential or integrodifferential equations
Authors: Herzallah Mohamed , Radwan Ashraf
Published: February 2023

The purpose of this paper is to give and prove the fundamental theorem of
conformable fractional calculus which is given only in previous associated
papers for differentiable functions, and then we scrutinize the existence
and uniqueness of solutions to some semilinear Cauchy problems for nonlocal
conformable fractional integrodifferential or differential equations which
their nonlinear terms include fractional derivative or fractional integral.
Two examples are investigated to elucidate the main results.
Factors Affecting Adoption of Climate Change Adaptation Strategies by Small Holder Farmers in Mountain and Lowland Agro-ecological Zones of Eastern Uganda
Authors: Turyahabwe Remigio , Turybanawe Loy Gumisiriza , Asaba Joyfred , Mulabbi Andrew , Geofrey Mukisa
Published: February 2023

Farmers in tropical rural areas are confronted with several challenges but outstandingly climate change which can only be overcome by adopting to climate change resilience strategies. This study assessed the factors affecting adoption of climate change resilience strategies in Muyembe sub-county, Bulambuli district, Uganda. We used questionnaires, interviews, focused group discussions and field observations to collect the required data, which was analyzed using basic descriptive statistics and logistic regression model. Results indicate that, the dominant climate change resilience strategies adopted in the study were, soil/water conservation (65%), drought resistant crop varieties (59.4%), and irrigation (55.6). Results of the logistic regression indicated that, gender and family size were the most important factors that influenced adoption of climate change resilience strategies with coefficient -0.86 and P0.05, and0.18 and P0.05 respectively. On the other hand, the barriers to adoption of the same by majority farmers were dominated by financial constraints and adulteration of farm inputs at 93.4% and 74% respectively. We concluded that, many farmers are still locked in indigenous practices that have made them vulnerable to climate change effects characterized by low yields, crop failure hence low incomes, poverty and food insecurity. We recommended that, government should support the adaptation strategies to climate change by the smallholder farmers technically by providing both ground and surface water irrigation facilities and financially by providing agricultural loans as well as focusing on promoting awareness and advancing education on climate change to farmers through knowledge and skill sharing platforms such as training, conferences, and seminars.
Predisposition Factor of Safety of Landslide Dams from Typhoon Talas, Kii Peninsula, Japan
Authors: Rikuto Daikai , Christopher Gomez , Bradak Balazs , Saputra Aditya , Hadmoko Danang Sri
Published: February 2023

Landslide dams are less frequent than other landslides, and their very existence is often very-much short-lived, because the temporary dam tends to collapse rapidly. Because of the resulting lack of evidences, there has been less research done on this topic, although the potential catastrophe they can be at the origin of needs assessment. For this purpose, the present contribution aims at differentiating landslides that trigger dams against those that do not inside a group of valleys of the Kii peninsula in Japan, where landslides occurred after the typhoon Talas in 2011. Using topographic map before the event and LiDAR data in its aftermath, the authors have calculated the factor of safety (FS) of different landslides in the same valleys, comparing the data of landslides that created dams against those that did not. The results show that landslides that triggered dams seemed to have a higher FS than those that did not. The authors suggest that it is because larger landslides are needed and thus appear more stable, but also because at the location where the slopes are stable, the riverbed can incise further instead of growing horizontally, and thus the sediments damming the channel have more chances to block it (as it is narrow) and stop the river from flowing.
Corrosion behavior of super austenitic stainless steel, Duplex 2205 and 316L in sulfamic acid environment
Authors: Roszardi Bashari Rohululloh , Riastuti Rini , Budiarto Wahyu , Darsono Nono , Syahid Adi Noer
Published: February 2023

Currently, sulfamic acid as a primary chemical industrial material is ubiquitous. One of its uses is a sweetener. Due to its corrosive nature, it is necessary to use a suitable container to avoid contamination of the solution. Corrosion behavior of super austenitic stainless steel, duplex 2205, and 316L uncovered to sulfamic acid in diverse attention at ambient temperature had been investigated. Concentration Weight loss method, Potentiodynamic Polarization, and Electrochemical Impedance Spectroscopy (EIS) examined the corrosion rate. The result showed that the corrosion rate of material increased with the increasing concentration of sulfamic acid. Super austenitic stainless steel has higher corrosion resistance than duplex 2205 and 316L.
Evaluation of learning program subjects for building utility systems based on facilities and infrastructure standards using the CIPPO model at SMK N 2 Banda Aceh
Authors: Ahzaliza Dian , Maksum Hasan , Wakhinuddin Wakhinuddin , Indrawan Eko
Published: February 2023

Based on interviews at SMK Negeri 2 Banda Aceh in 2021, obtained from 25 students, 4 people did not pass the skills test in the subject of building utility systems, with an average knowledge score of 79.2 and an average skill score of 78.4 One of the factors is the inadequate infrastructure in carrying out the learning process, especially practicum learning. The purpose of the study was to evaluate the learning process of building utility system subjects in the Construction and Property Engineering Expertise Program using the CIPPO model at SMK Negeri 2 Banda Aceh City. This research is an evaluation research using the CIPPO model, namely the evaluation of the context, input, process, product and outcome. The type of research is a mixed method with Concurrent Triangulation Strategy. Sources of qualitative data were obtained from the Principal, Deputy Principal of the School of Facilities and Infrastructure, Head of the Construction and Property Engineering Expertise Program, Head of Lab and 5. Teachers who teach building utility systems at SMK Negeri 2 Banda Aceh. Quantitative data were taken from 40 students of class XII and XIII. The results showed that the context component was in the sufficient category (73.59%), the Input component was in the sufficient category (75.69%), the process component was in the sufficient category (72.01%), the Product component was in the sufficient category (66.5 %), and the outcome component is also in the sufficient category (73.25%). Because all components are in the sufficient category, it is recommended to make appropriate improvements to improve student achievement abilities in the subject of building utility systems in the Construction and Property Engineering Expertise Program at SMK Negeri 2 Banda Aceh.
Implementation of video learning to lmprove student learning outcomes at SMK N 2 Padang
Authors: Diar Maha Putri Handayani
Published: February 2023

During the COVID-19 pandemic, the learning process, which was usually carried out face-to-face in front of the class, could no longer be carried out. So that with the spread of the covid-19 virus, the teaching and learning process has turned into distance learning to limit the spread of the covid 19 virus. Online distance learning began in early March 2020. This requires educators to think about what methods and media will be used. used for the teaching and learning process. For this reason, learning videos (Youtube) are used in the classroom teaching process. The purpose of this study was to improve learning outcomes by applying learning videos (Youtube) in Class XII BDP 1 SMK N 2 Padang. Based on the data analysis of the first cycle to the second cycle there is an increase in learning outcomes. The percentage in the first cycle of 72.73% rose to 91.34% in the second cycle. The increase of 18.61% in the percentage result in both cycle I and cycle II has reached the percentage that the author set at the beginning of the study, which is 65%. The average student learning outcome in the first cycle was 82.57 with a percentage of 72.73%. At the end of the second cycle learning outcomes increased to 87.45 with a percentage of 91.34%. The minimum completeness standard in this study is 80 and the research indicator is determined that 80% of students complete above the SKM. In this study, there were 91.34% of students above the SKM. Based on the results of this study, it is suggested that teachers in the field of online business and marketing skills competency studies can use learning videos for online learning.
The effectiveness of learning media on the outcome of computer and basic network of vocational students
Authors: Devega Army Trilidia , Ambiyar Ambiyar , Panyahuti Panyahuti , Adi Novi Hendri , Riyanda Afif Rahman
Published: February 2023

Learning media is a tool that can help the teaching and learning process so that the meaning of the message conveyed becomes clearer and the goals of education or learning can be achieved effectively and efficiently. The results given to students in the form of an assessment after following the learning process with the value of knowledge, attitudes, skills in students with changes in behavior can also be called student learning outcomes. One source of student learning to obtain messages and information provided by the teacher so that learning materials can be further improved and form knowledge for students is using Learning Media. In this study, researchers used research and development (R&D) methods, and the ADDIE development model. This interactive learning media is designed using the Lectora application. The results of this study are the effectiveness of the media using time series results of student learning mastery increased by 20% effectively to improve student learning outcomes through tests. A score of 0.52 was obtained in the medium category.
Anticorrosive epoxy coatings enhanced with rice husk derived-graphene
Authors: Amalia Dinda Putri , Riastuti Rini
Published: February 2023

Coatings are the most common corrosion control practice. Therefore, it is very important to discover the most cost-effective and environmentally-friendly coating materials for sustainability. When dispersed in epoxy resin, graphene has barrier properties that improve the anticorrosive performance of the metal significantly. Graphene can be synthesized from agricultural waste. Herein, graphene derived from rice husk and epoxy resin was developed with solution mixing to prepare graphene-epoxy coating composites with enhanced anti-corrosive properties. X-ray diffraction, UV-vis spectroscopy, and scanning electron microscopy were used to characterize the synthesized graphenes. The anticorrosive properties of the coatings were characterized by potentiodynamic polarization and electrochemical impedance spectroscopy, which resulted in the corrosion resistance of synthesized graphene and commercial reduced graphene oxide being better than commercial graphene. The impedance and corrosion rate values of synthesized graphene are 1.77 x 105 Ω and 0.00011 mm/year.
Evaluation of ISO 9001 lead auditor training program using CIPP model at ATS training centre
Authors: Kifta Decky Antony , Ambiyar Ambiyar , Rizal Fahmi , Islami Syaiful
Published: February 2023

This research is performed to evaluate the implementation of ISO 900A Lead Auditor Training program using CIPP model evaluation method which comprising of four aspects i.e.: (1) Context, (2) Input, (3) Process and (4) Product. The research method is using mixed method by using both quantitative and qualitative methods, where the data are collected using sampling technique by distributing questionnaires to 15 trainers and 25 trainees or training participants. The data also enriched by using qualitative method of interview and observation done on trainers and training participants. The results of the research and studies show that the training program from the context aspects of the trainers is 80.65% and from participants is 80.45%, from the input aspects of the trainers and participants are consecutively 81.5% and 75.87%, from the process aspects are 79.2% and 71.87%, and from the product aspects of trainers and participants are 80.02% and 75.7%. This can be concluded that the range of TPR are from 71.87% to 81.5% which fall into ‘good’ and ‘very good’ categories.
The effectiveness of the product-based learning model corresponding to Indonesian national standard competency (SKKNI) for the furniture industry in learning applications of wood construction
Authors: R.A Ari Syaiful , Prima Fani Keprila , Gusmareta Yuwalitas , Yudistira Sukma
Published: February 2023

The industrial revolution era has significantly impacted Indonesian education's development. Education is not only monotonous to study students but also provides opportunities to develop themselves according to their interests and talents. In this lecture, students' practicum products usually only become waste and are not yet suitable for use and even worth selling. The researcher plans to develop a Wood Construction Application learning with a product-based learning approach combined with SKKNI no. 61 of 2021, the wood furniture industry standard. This research is essential to find the most suitable strategy or practice in the Wood Construction Applications lecture. This study aims to develop learning based on the wood furniture industry with a product-based learning approach. The type of research used is research and development with the ADDIE model. The targeted outputs are in the form of books. The experimental and control classes' results of the pretest and post-test obtained an average result of pretest 20 and post-test of 93.31. In the control class, the average results of the pretest were 22.5, and the post-test was 73.38. While the results of the N-Gain value in the experimental and control classes, the experimental class obtained a value of 0.92 with a high category. In the control class, a score of 0.65 is included in the medium category.
Risk indentification on superheater pipeline boiler of 600 MW power plants using a risk based inspection (RBI) method
Authors: Rahman Okky Helja Octora Syahida , Pratama Fikri Wahyu , Siradj Eddy S
Published: February 2023

Steam power plants are the most efficient type of power generation and can make a significant contribution to the demand for electricity resources. Steam power plants, in general, utilize energy derived from seawater to be process into steam in boilers so that often many pipe failures have occurred due to thinning due to corrosion caused by inappropriate water quality in small units and difficult to detect continuously. In general, inspection planning related to pipe thinning in steam power plants shows a minimal trend compared to inspections in the oil & gas industry. Moreover, it has no basic policy as to how inspection intervals and piping methods will be carry out. In this study, it carried out with the aim of conducting a risk assessment of boiler pipe failure so that it can provide a more optimal overview of the inspection plan. Analysis using Risk Based Inspection (RBI) will be used as a research reference to create the most effective and efficient inspection system as to minimize the impact and expenses cost in pipeline maintenance. After RBI assessment, the inspection plan for superheater pipeline on boiler line will be held every 2 years.
Level of interest and performance of tourism facilities in the attraction of the peak tourism of Paragliding
Authors: Fariansyah Ilham , Pasaribu Pasaribu
Published: February 2023

This research started from observations, which were seen based on data from Puncak Paragliding tourist visits which decreased from January to September, this occurred due to the outbreak of the Covid - 19 pandemic that entered and resulted in the imposition of a lockdown system or PSBB in almost all regions in Indonesia including the city of Padang. . Where the government prohibits residents from making tourist visits in order to prevent the transmission of the Covid-19 pandemic. Only in the last three months of 2021 has the level of tourist visits coming to the Puncak Paragliding tourist attraction experienced a significant increase, this is of course accompanied by implementing strict health protocols. Researchers also observe other problems, namely as a tourist attraction Puncak Paragliding is faced with the challenge of being able to attract tourists who want to visit. This is certainly important to do because as one of the businesses engaged in services. In addition, facilities are facilities and infrastructure that play an important role in efforts to increase tourist satisfaction. The results showed that there were 6 indicators in quadrant 1 (Concentrate Here, Top Priority) High Importance, Low Performance, there were 2 indicators in quadrant 2 (Keep Up The Good Work, Maintain Performance) High Importance, High Performance, there were 2 indicators that are in quadrant 3 (Low Priority) Low Importance, Low Performance and there are 3 indicators that are in quadrant 4 (Possibly Overkill, Excessive) Low Importance, High Performance.
Cultural transfer of Europe’s common heritage of the English origin in phraseology
Authors: Hudcovičová Marianna
Published: February 2023

Europe’s common heritage (culture, history, traditions) has had a great impact on the languages sharing the same territory of the European continent. The influence of the mutual relationships between nations is predominantly visible in phraseology of each European language. The article deals with occurrence of certain multiword expressions, phraseologisms, e.g. collocations, idioms, idiomatic comparisons originated in common European source of the English origin, i.e. British and American phraseologisms, quotations of well-known British and American writers, philosophers, politicians, etc. The analysis focuses on the contrastive approach to the English and Slovak phraseology.
The Intensity of The Constitution According to Dustur Saudi Arabia
Authors: Arlis Arlis , Yuherlis Neni
Published: February 2023

Types of constitution in the perspective of Dustur Saudi Arabia is the main problem of the study. Article 1 of the Saudi Arabian State states that the State of Saudi Arabia is the daulah of Islamic Arabia, its religion is Islam, its constitution the Book of Allah Ta'ala and the Sunnah of His Messenger. The existing provisions show that the constitution according to Dustur Saudi Arabia is diverse, has dynamics and intensity. The purpose of the study is to uncover the intensity of the constitution. Normative legal research is used as a method with an approach to the substance and intensity of law. The results of the study revealed that the constitution according to Dustur Saudi Arabia has a great variety with superior intensity. The variety is Nizham Al-Asasi lil-Hukm, The Qur’an, the Sunnah, and the Median Constitution. This varieties have a very close and inseparable relationship. the al-Kitab is at the highest and strongest level, followed by the Sunnah, Dustur Medina, and Nizham Al-Asasi lil-Hukm. Saudi Arabia's dustur has an intensity that is in line with maqashid al-shari'ah which includes the protection of all aspects of world life and the hereafter. The novelty is the Book of Allah was the first and foremost written constitution in the world. The conclusion is that the intensity of the constitution according to the Dustur Saudi Arabia is very strong and highest level. The al-Kitab and the Sunnah are absolutely references in formulating, establishing, and implementing the constitution and all the rules.
Új terápiás stratégiák a diabéteszes vesebetegség kezelésében
Authors: Balogh Zoltán
Published: February 2023

A diabéteszes vesebetegség az 1-es és 2-es típusú cukorbetegek 20–40%-ában alakul ki, egyúttal a dialízisigényű végstádiumú vesebetegség vezető oka. A krónikus vesebetegség jelentősen növeli a szív-érrendszeri morbiditás és mortalitás rizikóját, valamint az egészségügyi ellátás költségeit. Az utóbbi években az SGLT-2-gátlók, GLP-1-receptoragonisták, valamint az új, nemszteroid mineralokortikoidreceptor-antagonisták ígéretes előrelépést jelentenek a diabéteszes vesebetegség kezelésében, egyúttal a korábbi glükocentrikus terápiás szemlélet helyett előtérbe került az igazolt kardiorenális előnnyel bíró gyógyszerek alkalmazása. A szerző ezen újabb adatokat tekinti át.
A GLP-1-receptoragonista liraglutid direkt hatásai az érfali diszfunkcióra 2-es típusú cukorbetegségben
Authors: Sztanek Ferenc , Pető Attila
Published: February 2023

A GLP-1-receptoragonista liraglutid kedvező hatásait a kardiovaszkuláris betegségek kialakulására klinikai vizsgálatok támasztották alá, ezek hátterében az endotéliumra és az érfali sejtekre kifejtett gyulladáscsökkentő, oxidatív stresszt mérséklő, az ateroszklerózis progresszióját gátló és plakkstabilizáló direkt hatások is feltételezhetőek az indirekt kardiovaszkuláris kockázatcsökkentő hatások mellett. A GLP-1-receptoragonisták közül a liraglutid alkalmazásával kapcsolatban áll rendelkezésünkre a legtöbb adat az endotélium funkciójára kifejtett hatásokról inzulinrezisztenciában és 2-es típusú cukorbetegségben. A liraglutid gátolja az oxidatív stresszfolyamatokat az endotélsejtekben, csökkenti a glükotoxicitást krónikus hiperglikémiában és akut vércukor-ingadozás esetén is. A reaktív oxigéngyökök termelődésének csökkenésével az endotél funkciója javul, fokozódik a nitrogén-monoxid-termelődés és mérséklődik az endotéldependens vazokonstrikció. A liraglutid gátolja a gyulladásos sejtek érfali adhézióját és migrációját, az oxidált LDL képződését és a makrofágok habossejtekké alakulását, így direkt módon mérsékli az ateroszklerózis folyamatát. Az endotélium funkciójára kifejtett kedvező hatás kulcsfontosságú tényező lehet a GLP-1-receptoragonisták kardiovaszkuláris hatásainak megértésében.
Improving Integrity in Research and Higher Education: An Indonesian Perspective [Meningkatkan Integritas Dalam Riset dan Pendidikan Tinggi: Sebuah Perspektif Indonesia]
Authors: Kozok Ulrich , Siaputra Ide Bagus
Published: February 2023

Students and lecturers have challenges in publishing the results of their researches and studies as a requirement for graduation, promotion, or performance evaluation for institutions. This can bring up a variety of behaviors in producing scientific papers, ranging from those that should be emulated, questioned, doubtful, to being considered violations. The Indonesian government has issued regulations on academic integrity in producing scientific papers, but there are still new challenges such as misinformation and the use of artificial intelligence. Therefore, there is a need for indicators received together about the level of reasonableness in producing scientific work. This indicator must be relevant globally and accommodative to the local context. To strive for this, it is important to strive for dialogue between the academic community and the government to review publication policies and ensure that the regulations are effective and adaptive to the times and technological progress.

 

Mahasiswa dan dosen memiliki tantangan dalam mempublikasikan hasil penelitian dan studi mereka sebagai syarat kelulusan, kenaikan jabatan, atau evaluasi kinerja bagi lembaga. Hal ini dapat memunculkan beragam perilaku dalam menghasilkan karya ilmiah, mulai dari yang patut dicontoh, dipertanyakan, meragukan, hingga dianggap pelanggaran. Pemerintah Indonesia sudah menerbitkan peraturan tentang integritas akademik dalam menghasilkan karya ilmiah, namun masih ada tantangan baru seperti misinformasi dan penggunaan kecerdasan buatan. Maka dari itu, perlu ada indikator yang diterima bersama tentang tingkat kewajaran dalam menghasilkan karya ilmiah. Indikator ini harus relevan secara global dan akomodatif dengan konteks lokal. Untuk mengupayakan hal tersebut, penting untuk mengupayakan dialog antara sivitas akademika dan pemerintah untuk meninjau kembali kebijakan publikasi dan memastikan bahwa peraturan tersebut efektif dan adaptif terhadap perkembangan zaman dan kemajuan teknologi.
Kegiatan penyediaan pelayanan perpustakaan dalam layanan unggah mandiri tugas akhir: studi kualitatif layanan unggah mandiri tugas akhir di Telkom University Open Library
Authors: Khoerunnisa Rozaanah , Sukaesih Sukaesih , Rodiah Saleha
Published: February 2023

This study was conducted against the background of the emergence of news regarding the disposal of a student's final scientific assignment by one of the university libraries in Indonesia which at that time had become the focus of attention. In addition, the developments that occurred in the handover service for students' final scientific assignment also became the background for this study. This study aims to determine the technical service activities consisting of collecting, processing, disseminating, and preserving that are carried out by the library in supporting the implementation of the final assignment self-upload service at Telkom University Open Library. The research method used in this study is a descriptive qualitative method. Data was collected using observation, interviews, and documentation techniques. The research informants are library staff of Telkom University Open Library. The validity of the data was tested by triangulation techniques and source triangulation. Data analysis was carried out by data reduction, data presentation, and concluding. The results of the study provide information that technical service activities in the final assignment self-upload service at the collecting stage are carried out by library staff by verifying documents and the “Surat Bebas Kewajiban Perpustakaan” (Library Liability Free Letter) administrative requirements which consist of free of library loans and fines, and donating a book following the provisions. Processing activities are carried out by the processing staff by inputting document catalogs, inputting journal articles of the final project to Tel-U e-Proceeding, and making FlipBooks. Disseminating activities are carried out by providing final project collections and Tel-U e-Proceeding. Information dissemination activities are carried out by holding literacy class and distributing infographic content with the aim of attracting use from library users. Preserving activities are carried out by making metadata backups, document backups in docx and PDF format on external hard disk, and maintaining library websites.
Análisis de la calidad de la educación infantil: situación actual, instrumentos de evaluación, contribución de familias y docentes
Authors: González-Benito Ana
Published: February 2023

Se presenta la reseña de una tesis doctoral por compendio de publicaciones centrada en conocer el estado de la calidad en Educación Infantil (EI) en España, con especial referencia al primer ciclo. Para ello, se lleva a cabo una revisión sistemática para identificar y valorar los estudios sobre evaluación de la calidad de la EI. Asimismo, se aplica el cuestionario ITERS-3 (Infant/toddler Enviroment Rating Scale) para evaluar la calidad del ambiente, y se diseñan, validan y aplican dos cuestionarios ad hoc sobre el tipo de relación escuela-familia y las actividades e indicaciones proporcionadas. Entre los resultados más relevantes destaca que la cooperación familia-escuela está asociada al nivel educativo de los progenitores y el tipo de escuela teniendo en cuenta su titularidad (públicas, concertadas o privadas), así como que casi la mitad de las familias encuestadas demandan recibir más indicaciones por parte del profesorado para que sus hijos/as puedan llevar a cabo las actividades encomendadas.
La mejora de la enseñanza y el aprendizaje en la universidad
Authors: Porlán Ariza Rafael
Published: February 2023

Se presenta la reseña de tres obras cuyo nexo radica en cómo la Universidad de Sevilla ha venido aplicando durante 9 años el Programa FIDOP (Formación, Innovación e Investigación Docente del Profesorado) (https://institucional.us.es/fidopus/), orientado hacia una enseñanza centrada en el estudiante y el aprendizaje y basado en Ciclos de Mejora en el Aula.
Stent embolization in stented segment: a diagnostic challenge
Authors: Shroff Jenish , Lalani Kanhai , Parikh Pankti
Published: February 2023

Stent dislodgement during angioplasty is a rare but potentially fatal complication if not properly managed. We described a case of an elderly man who had previously undergone coronary angioplasty and now presented with an inferior wall myocardial infarction and required emergency angioplasty. Because of the loss of antegrade flow during the procedure, the proximal lesion was stented first. Undeployed stent was dislodged into proximal stent during distal stent deployment through proximal stent. This complication was addressed by crushing the undeployed stent and deploying another stent to secure the crushed stent to the arterial wall. Postprocedure patient was stable and discharged after 2 days. An operator should be aware of this risk as well as possible bailout options.
Analogous Mode Implementation of State Space Based Control of Buck Converter
Authors: Cucoș Diana-Elena , Neacșu Dorin O.
Published: February 2023

The new requirements for point-of-load converters include the dynamic behavior, leading to the need for improvements in the control system for the conventional buck converter. Usually, the regulator design, in order to secure stability at parameter or mode variation, aims a zero steady-state error and a phase margin over 60 degrees. The design based on Venable’s K-factor method (Venable, 1983) helps achieve this topic. A more modern control design method based on State Space is used progressively on digital platforms. This paper extends the merits of the State Space based design procedure with an analogous mode implementation.