bluuebunny/crossref_metadata_2025 huggingface dataset:
Lung cancer in Kazakhstan: age-gender features
Authors: KAIDAROVA D. R. , SHATKOVSKAYA O. V. , ZHOLDYBAY Zh. Zh. , ZHYLKAIDAROVA A. Zh. , PANINA A. S.
Published: September 2021

Relevance: Over the years, lung cancer (LC) remains the leading cause of cancer deaths in Kazakhstan. In 2018, LC was

diagnosed in 3741 people in the RK, and 2377 dies from LC.

The purpose of this study was to assess the age-gender characteristics of morbidity and mortality from LC in Kazakhstan

based on statistical and literature data.

Results: The conducted analysis by gender and age showed a consistent and significant increase in LC mortality in the RK,

starting from the age of 40-44 years. The highest incidence and mortality were registered in the age groups of 65-69 years and

70+ years. In general, in all age categories, the incidence and mortality in men exceeded the incidence and mortality in women by

4.5–5.3 times. The highest mortality in men and women of all ages was registered in 2009 (34.3‰ and 6.9‰, respectively), the

lowest – in 2019 (20.8‰ in men and 4.6‰ in women).

Conclusions: The results of the assessment can be used to improve early diagnosis of LC and in the preparation of national

screening programs and regional pilot projects for LC prevention and the identification of risk groups. The use of the results

will contribute to increasing the effectiveness of treatment, improving the five-year survival of patients, reducing the level of

neglect and mortality from LC.
Successful live birth after fertility-sparing
treatment in grade II endometrial cancer:
A case report
Authors: KUKUBASSOV E. K. , BOLATBEKOVA R. O. , SATANOVA A. R. , BERTLEUOV O. O. , KALDYBEKOV D. B. , KOVCHEGOV I. O.
Published: September 2021

Relevance: The growing incidence of endometrial cancer among young women urges the use of fertility-sparing therapy.

The purpose of this study was to demonstrate the results of using fertility-sparing therapy in a woman with endometrial

cancer, FIGO stage IA GII.

Results: After the combination hormone therapy with gonadotropin-releasing hormone (diphereline 3.75 mg every 28

days) using a hormone-releasing intrauterine device, the patient with endometrial cancer stage 1, GII demonstrated a complete response to treatment and delivered a live newborn.

Conclusion: Surgery remains the primary treatment for the early stages of endometrial cancer. However, hormone therapy

can preserve fertility in young women with highly differentiated early-stage endometrial cancer. The described schemes of

hormone therapy can be used in young patients.
Calculation of the cost-effectiveness
of subcutaneous administration of trastuzumab
Authors: OMAROVA I. M. , NURKETAEVA J. O. , DOROGAN D. D.
Published: September 2021

Rational selection of medicines with an assessment of their pharmacoeconomic effectiveness is the most effective way to

ensure safe and efficient treatment and economical use of budget funds allocated for drug therapy, as well as to reduce the

time of hospitalization and treatment of patients.

The purpose of the research was to evaluate the pharmacoeconomic effectiveness of using the subcutaneous and intravenous forms of drug Trastuzumab.

Research tasks:

1. Estimate costs when using subcutaneous trastuzumab in an outpatient chemotherapy room (OCR).

2. Estimate costs when using intravenous trastuzumab in a day patient department (DPD).

3. Estimate costs when using intravenous trastuzumab in a round-the-clock hospital.

Results: The paper presents the pharmacoeconomic analysis of targeted therapy with trastuzumab in two forms for intravenous administration (IV) and trastuzumab emtansine for subcutaneous administration (SC) in breast cancer by cost minimization method.

The costs of used drugs are according to the price-list of the unified national distributor SK Pharmacia as of January 1, 2018.

At comparable efficacy and toxicity, the estimated cost-effectiveness of trastuzumab per 100 patients per year is

KZT 16,939,600 ($ 50,972) for SC administration in OCR and IV administration in DPD vs. KZT 41,783,200 ($ 125,728) for

SC administration in OCR and IV administration in a round-the-clock hospital.

Conclusions: Based on the above, the subcutaneous form is economically feasible for conducting targeted therapy with

trastuzumab.
Cutaneous leiomyosarcoma/
atypical smooth muscle sarcoma
Authors: SATBAYEVA E. B. , MUCHAMETGALIEV N. A. , ISKAKOVA E. E.
Published: September 2021

Relevance: Cutaneous leiomyosarcoma is a rare primary dermal neoplasm, accounting for up to 2-3% of all superficial

sarcomas. It can occur at any age, most likely between the ages of 50 and 70 years. This tumor has a high recurrence potential

in case of insufficiently deep excision. Recurrent tumors are more aggressive and characterized by subsequent metastasis.

The purpose of the study was to demonstrate the results of the histopathological examination of a cutaneous

leiomyosarcoma / atypical smooth muscle tumor.

Results: Cutaneous leiomyosarcoma was represented by spindle-shaped cells with high cellularity located in bundles

and growing expansively, surrounded by a capsule. The nuclei of the cells were elongated, hyperchromic. Cells with atypical

abnormal nuclei were present in smaller quantities. The mitoses, including atypical, were numerous. IHC staining for SMA,

Desmin, H-Caldesmon – diffusely positive on tumor cells. The reaction for S100, Myogenin – negative.

Conclusion: A cutaneous leiomyosarcoma can be finally diagnosed only after a pathomorphological examination of the

specimen and differential diagnostics using additional research methods
Intraoperative risk assessment
of carcinomatosis development
after radical surgery for gastric cancer
Authors: REUTOVICH M. YU. , KRASKO O. V.
Published: September 2021

Relevance: Metachronous peritoneal dissemination (PD) is the most frequent pattern of gastric cancer (GC) progression

after radical surgery. It is necessary to take into account the existing risk of developing metachronous PD to ensure a substantiated administration of intraperitoneal chemotherapy (ICT) for its timely prevention.

The purpose of the study was to raise the metachronous PD prognostication efficacy.

Results: The treatment outcomes of 1,065 radically operated patients (males – 640, 60.1%; females – 425, 39.9%) aged 23 to 89

years (median age – 63±12) showed that a high risk of GC recurrence in the form of peritoneal dissemination is associated with:

(1) metastatic invasion of the regional lymph node – pN2-3 – RR 2.0 (95% CI 1.5–2.7), р < 0.001; (2) ulcero-infiltrative and diffuse

infiltrative forms of primary gastric cancer growth – RR 3.7 (95% CI 2.5–5.5), р < 0,001), and RR 2.3 (95% CI 1.5–3.6), р<0,001;

(3) serosa invasion by primary GC (pT4) – RR 2.5 (95% CI 1.8–3.6), р<0,001; (4) combined surgical treatment vs. standard surgery –

RR 1.8 (95% CI 1.2–2.7), р=0.005; and (5) performing gastrectomy vs. distal resection – RR 1.6 (95% CI 1.2–2.2), р=0.004.

A multivariate analysis (Fine-Grey model) was done to propose a prognostic model for an intraoperative estimate of the

MPD development probability to determine indications for intraoperative ICT (concordance index – 0.75).

Conclusion: The proposed nomogram- or formula-based prognostic model allows a differentiated approach to administering intraoperative ICT, taking into account the existing probability of peritoneal dissemination development.
Early diagnostic of lung cancer based
on methylation of mononuclear cell fraction:
Method development
Authors: GONCHAROVA T. G. , KAIDAROVA D. R. , KADYRBAYEVA R. E. , ORAZGALIEVA M. G. , ADILBAY D. G. , CHEISHVILI D. , VAISHEVA F. , SZYF M.
Published: September 2021

Relevance: According to the International Agency for Research on Cancer (IARС), lung cancer (LC) today ranks first in cancer

incidence worldwide [1]. In the Republic of Kazakhstan, about 3800 new cases of LC and more than 2000 deaths from LC are

registered each year (one-year mortality exceeds 49.4%) [2]. This supports the relevance of early LC diagnostics. The study of

DNA methylation in human peripheral blood mononuclear cells (PBMC) suggests its use as an early diagnostic and prognostic

marker for LC before detecting a malignant neoplasm by visual diagnostic methods.

The purpose of the study was to find specific diagnostic and prognostic markers by DNA methylation profiling of PBMC

in patients with LC.

Results: Methylation markers of blood mononuclear fraction were detected in CG islets associated with genes ICAM5,

mir138, SYNE1, and KLK4 in 97% of plasma samples from patients with LC and were absent in healthy people. The usability of

these markers to differentiate LC from 16 other cancers using NCBI GEO and TCGA methylation data was demonstrated with a

specificity level of 0.96 and a sensitivity of 0.84.

Conclusion: The specificity and sensitivity of the method of LC early diagnostics and prognosis based on the methylation of

blood mononuclear cells (detection of methylation of CG islets associated with the ICAM5, mir138, SYNE1, and KLK4 genes in

PBMC) are enough to use it in screening for LC.
Epigenetic research in lung cancer diagnostics:
A literature review
Authors: KADYRBAYEVA R. , ASKANDIROVA A. , OMARBAYEVA N. , ADYLBAI D. , GONCHAROVA T. , ORAZGALIEVA M.
Published: September 2021

Relevance: According to the International Agency for Research on Cancer (IARC), lung cancer (LC) currently ranks first in

cancer incidence and mortality worldwide. The gold standard of LC diagnostics is the histological verification, the determination of the degree of invasion and tumor phenotype. At first glance, epigenetic methods seem to be secondary after determining the patient’s genetic profile. However, standard genetic analysis reveals only the DNA nucleotide sequence. Thus, epigenetic

analysis is the only method that allows detecting potential abnormalities in cells. An important difference between genetic and

epigenetic changes is that drugs are efficient against epigenetic changes but absolutely powerless against genetic mutations.

The purpose of the study was to review and analyze the available molecular genetic methods for DNA methylation profiling in lung cancer.

Results: All these observations support the hypothesis that methylation profiling in body fluids can help determine the people predisposed to or affected by LC. Circulating acellular DNA in the blood plasma contains tumor-specific mutations and disease-related DNA methylation patterns. Identifying new biomarkers-precursors of a potential cancer susceptibility or aggressiveness in such DNA would be a considerable advancement in prognostic medicine for patients at high risk of developing LC.

Conclusion: A low level of LC detection might limit the number of DNA samples of patients with LC included in the studies.

This is also the reason why specific methylation biomarkers have not yet been confirmed for clinical use. Future research on

a larger number of blood samples, combined with the entire epigenome studies, may contribute to finding a group of LC biomarkers to improve LC detection.
Epigenetic markers-based breast cancer
early detection method development
Authors: GONCHAROVA T. , KAIDAROVA D. , OMARBAYEVA N. , ASKANDIROVA A. , ORAZGALIYEVA M. , ADILBAY D. , CHEISHVILI D. , VAISHEVA F. , SZYF M.
Published: September 2021

Relevance: According to the International Agency for Research on Cancer (IARС), breast cancer ranks 1st-2nd among other cancers globally [1], including Kazakhstan [2]. In Kazakhstan, the annual growth in breast cancer incidence exceeds 26.6%. In 2018-2019, breast cancer

was the 3rd most common cause of cancer death in Kazakhstan, accounting for 8.7-8.1 percent, respectively. Early detection of breast cancer

remains an acute issue. In particular, early detection should be improved. Epigenetic studies of cancer patients confirm that epigenetic biomarkers could be used as early cancer diagnostic markers, including breast cancer.

The study aimed to find specific diagnostic markers by methylation profiling of peripheral blood mononuclear cell (PBMC) DNA in breast

cancer patients.

Results: Plasma samples of the Kazakhstani population with breast cancer possessed mononuclear cell methylation markers in CpG islets associated with JAM3, C17orf64, MSC, and C7orf51 genes and the CpG islet associated with the intergenic region on chromosome 5, chr5:

77,208,034-77,329,434, which were missing in healthy individuals. These biomarkers allow differentiating breast cancer from other cancers

with a specificity of 0.91 and a sensitivity of 0.94 compared to methylation data from open DNA methylation databases (for Illumina 450K):

TCGA, GSE40279, GSE61496, GSE76269 и GSE66836.

Conclusion: Early breast cancer detection method using peripheral blood mononuclear cell DNA methylation profile, namely in CpG

islets associated with JAM3, C17orf64, MSC, and C7orf51 genes and the CpG islet associated with the intergenic region on chromosome 5,

chr5: 77,208,034-77,329,434 is enough specific and sensitive to use it in breast cancer screening.
Use of an artificial intelligence program
in radiation therapy
Authors: ISHKININ Y.I. , DATBAYEV K. , RAIMBEKOV R. , IBRAYEV R. , AKHUNOVA R. , RAIMZHANOV K. , GONCHAROVA A. , TURLYBEK Zh. , KALDARBEKOVA G.
Published: September 2021

Relevance: Since 01 January 2020, the provision of radiation therapy (RT) at Almaty Oncology Center was optimized using

the Visual Care Path (VCP) tool of the ARIA 15.6 oncology system, which supports the implementation of sequential and parallel

mandatory procedures – from patient registration to completion of treatment.

The purpose was to study the impact of the implemented artificial intelligence system on RT effectiveness, safety, the share

of complex RT techniques, and measure staff satisfaction and proficiency.

Results: The share of intensive modulated radiation therapy sessions changed from 39.3% in 2019 to 46.6% in 2020. After

the implementation of VCP, timely pre-irradiation preparation of patients (centering, delineation, dose prescription) by department doctors increased from 76% to 91%, OR = 3.2; timely measurements of plans increased from 85% to 96%, OR = 4.7;

the frequency of major events (the ratio of plans with errors or unsuccessful plans to the total number of plans, delineation of

organs at risk and targets, dose prescription) decreased from 12% to 3%, OR = 4.5; the frequency of minor events (late notification of the patient of the treatment commencement, timely transition to the next stage of patient preparation for treatment

decreased from 32% to 10%, OR = 4.5. Staff proficiency in VCP has increased by 75%. Following the anonymous survey results,

85% of staff reported a positive impact of VCP on the workflow.

Conclusion: The share of complex methods of RT has increased by 7.3%. The implementation of VCP significantly increased

the workflow efficiency – by 3.9 times, reduced the number of major and minor events by 4.4 times. It allowed using a paperless

communication with the executor’s identification at each stage of RT. The new technique was also quickly adopted and favorably accepted by the staff.
Manifestações do fantástico na literatura brasileira contemporânea
Authors: Maciel Maria Ellem Souza
Published: September 2021

Apresentando uma produção nacional, em certa medida, marginalizada, durante longos anos o fantástico não teve o devido respaldo da academia no Brasil. Esse cenário vem se transformando nas últimas décadas e é nessa perspectiva que se insere a publicação deste Manifestações do Fantástico na Literatura Brasileira Contemporânea. Este livro busca ampliar o conhecimento e o estudo da prosa fantástica brasileira no século XX, ao provocar a análise sobre as formas contemporâneas do insólito que ultrapassam a categorização clássica de Tzvetan Todorov em Introdução à Literatura Fantástica.
Nadir Bir Eritema Nodusum Nedeni Olarak Epstein-Barr virüs; Bir Olgu Sunumu ve Literatür Taraması
Authors: KİLİÇASLAN Önder , KIZMAZ İŞANÇLI Didem , TÜLÜBAŞ Hatice , ULUTAŞ Ömer , NABALİYEVA Aygül , KARBUZ Adem
Published: September 2021

Eritema nodozum (EN) en yaygın septal pannikülit şeklidir. Vakaların %50'sinde hiçbir neden bulunamaz. Tanımlanmış nedenlerin en önemlilerinden biri enfeksiyonlardır. Epstein-Barr virus (EBV) de nadir bir EN nedenidir. Onbeş yaşında kız hasta bir gün süren ateş ve bacaklarda daha belirgin ağrılı kızarık lezyon nedeni ile acil servise başvurdu. Fizik muayenesinde ön kol iç yüzünde ve bacaklarda en büyüğü 3*5 cm olan eritemli zemin üzerinde bulunan ağrılı nodüller dışında bulgu yoktu. Ön planda EN düşünülen hasta servise yatırıldı. Yapılan tetkiklerde tam kan sayımı normal idi. Akut faz reaktanları yüksek bulunan hastanın alınan boğaz, idrar ve kan kültürlerinde üreme saptanmadı. Etiyolojye yönelik yapılan mikrobiyolojik testlerden sadece anti-viral kapsid antijen (VCA)-IgM ve IgG testi pozitif saptandı. EBV’ye bağlı EN tanısı alan hasta semptomatik tedavi ile takip edildi. Yatışının 8. gününde ağrısı ve lezyonları gerileyen hasta taburcu edildi. EBV’nin en sık cilt bulgusu makulopapüler döküntü olsa da EN’nin saptandığı hastalarda EBV de akılda bulundurmalıdır.
Estimation of general combining ability (GCA) in fifteen Cucumis sativus L inbred lines of the fifth generations
Authors: Hoang Hiet D.
Published: September 2021

The study on General Combining ability (GCA) of 15 cucumber inbred lines (I5) was carried out at the Research and Development Center for High-tech Agriculture, Ho Chi Minh City. The objective of the study was to identify the appropriate parental lines for producing F1 hybrid cucumber cultivars. Experimental materials included 15 cucumber inbred lines (I5) (L3, L9, L21, L22, L28, L32, L33, L36, L39, L61, L63, L69, L71, L74 and L78) and two test lines (T1 - TN 456 from Trang Nong Company, imported from Thailand and T2 - Cuct 1450 from Chia Tai - Thailand), forming 30 hybrid combinations by the method of topcross. The results showed that seven inbred lines including L3, L9, L21, L28, L33, L61 and L71 had high ability to combine with both T1 and T2 tester lines abby fruit yield with GCA index from + (0.8) to + (9.4). Evaluation of 30 cucumber hybrid was combinations on the growth and fruit yield characteristics showed that L28/T1 and L71/T2 hybrids were significantly different from other hybrids with high yields of 43.1 tons/ha and 41.3 tons/ha, respectively
Effects of dietary supplementation of vitamin E on reproductive performance of Japanese laying quails
Authors: Nguyen Khang T. K.
Published: September 2021

The objective of this study was to evaluate the effects of dietary supplementation of vitamin E on reproductive performance of Japanese (JP) laying quails from 49 - 132 days of age. A total of 40 JP quails of 49 days of age were randomly assigned to 1 of 4 dietary treatments and there were 10 replicate cages per treatment with each JP quail per replicate. The experimental diets were as follows: (1) the control was a basal diet without vitamin E supplementation (KPCS); (2) E75 consisted of KPCS supplemented with 75 mg vitamin E per kg of feed; (3) E100 consisted of KPCS supplemented with 100 mg vitamin E per kg feed, and (4) E125 consisted of KPCS supplemented with 125 mg vitamin E per kg of feed. The experiment was carried out for 12 weeks from December 23th, 2019 to March 15th, 2020. The results showed that from 105-132 days of age, the laying rate and egg weight of the E100 (93.57% and 11.42 g), control (90% and 11.58 g) and E75 (89.29% and 11.39 g) were significantly higher (P < 0.05) than those of the E125 (79.44% and 10.04 g), respectively. There were no significant differences among treatments in feed consumption and feed conversion ratio (P > 0.05). Egg parameters such as eggshell weight and its percentage, albumin percentage and eggshell thickness were significantly different among treatments (P < 0.05). Briefly, it is suggested that either 75 mg or 100 mg of vitamin E should be added to the feed to improve the egg performance of JP quails.
Accumulation of heavy metals in ducks exposed to heavy metals-contaminated water
Authors: Nguyen Ha N.
Published: September 2021

The objective of this study was to determine the bioaccumulation of heavy metals (HM) (Cu, Zn, Hg, Pb and Cd) in 15 tissues (brain, breast muscle, sternum, thigh muscle, femur, blood, heart, lung, gizzard, liver, intestine, spleen, pancreas, bile and kidney) of domestic ducks exposed to HM-contaminated water with levels equal to values specified in the column B of QCVN 40:2011/BTNMT. The experiment was a completely randomized design with two treatments: without exposure to HM (CT) and with exposure to HM (ET). Each treatment was replicated 3 times. Ducks were randomly allocated to the treatments with a stocking density of 10 ducks per cage and reared for 8 weeks. The results showed that concentrations of HM, particularly toxic metals such as Hg, Pb and Cd, in all tissues of duck in the CT were lower than those in the ET. The highest levels of HM in tissues were found in the liver and kidney. In the ET, Pb levels in kidney and bone and Cd levels in liver and kidney exceeded the permissible exposure limit according to the guidance of the Ministry of Health of Vietnam and the European Commission. This study demonstrated that the accumulation of HM in duck tissues could happen even though ducks were exposed to relatively low concentrations of HM in water. Thus, further investigation on the bioaccumulation of HM in farmed ducks as well as wild water-birds should be conducted in the near future.
Impact of temperature and relative humidity on physicochemical properties of the spray dried red flesh dragon fruit powder during storage
Authors: Duong Diep T. N.
Published: September 2021

This study was carried out to evaluate the effects of storage temperature (5 - 7oC, 29 - 31oC, and 50oC) and relative humidity (RH 10 - 84%) on the stability of antioxidant compounds such as betacyanin, polyphenols. The changes in color, moisture content, the water activity of spray-dried red flesh dragon fruit powder during storage were also observed. The results showed that after 40 days of storage at 5 - 7oC, the samples got betacyanin content of 3.76 mg/100 g dw and a total phenolic of 28.31 mg/100 g dw. These values were higher than those of samples stored at ambient temperature (29 - 31oC) and 50oC. Besides, this study also recorded that the low relative humidity of the environment at 10 - 23% maintained the product's betacyanin (4.16 - 3.61 mg/100 g dw) and polyphenol content (27.29 - 25.66 mg/100 g dw) as well as a desirable water activity, which was better than the zone from 57% to 84% (0.28 - 0.3).
Designing a database model of district-level land use planning with community consultation in Vung Tau city, Ba Ria - Vung Tau province
Authors: Truong Linh D. T.
Published: September 2021

Nowadays, building a land database and land use planning database is an indispensable requirement, especially for a seaport city as Vung Tau city (Ba Ria - Vung Tau province) where there are complex land fluctuations. Accordingly, a complete land use planning database with the participation of community will contribute to connecting planners, managers and people, and increase the publicity, transparency and feasibility of land use planning options. The study designed a database model of land use planning with the community consultation for Vung Tau city in accordance with the land data standards of Circular No. 75/2015/TT-BTNMT. Based on the designed model, a set of land use planning database with high accuracy was created and it was in line with the data standards of the Ministry of Natural Resources and Environment and the designed database model. This database structure contained 22 spatial data tables on ArcGIS and 8 attribute data tables (with the community consultation) on Microsoft SQL Server. Finally, we successfully used the VBDLIS software to build the land use planning database (period 2010 - 2020) for Vung Tau city with 6 data layers, including land use planning data layer (15.060 records), project layer (163 records), adjustment layer for land use planning (12.002 records), adjustment layer for project (570 records), and 2 attribute data layers of community consultation. The results of this study indicated that the correct model and complete database structure were the basis for successfully building and effectively exploiting the database of land use planning. The designed model could contribute to the planning of land management and improve the efficiency of land use.
Estructura de la Regla de San Agustín (V)
Authors: Luis Vizcaíno Pío de
Published: September 2021

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Jesús y los cínicos
Authors: Mielgo Fernández Constantino
Published: September 2021

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La fe en la creación
Authors: Joven Álvarez Fernando J.
Published: September 2021

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Freud y la religión obsesiva
Authors: Maza Bazán Pedro
Published: September 2021

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La nueva edición de las obras de Ernst Cassirer
Authors: Joven Álvarez Fernando J.
Published: September 2021

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Estructura de la Regla de San Agustín (X)
Authors: Luis Vizcaíno Pío de
Published: September 2021

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Entre Sísifo y Dionisio. Evangelizar en una cultura trágica
Authors: Bueno de la Fuente Eloi
Published: September 2021

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Elegir obispos, renovar la Iglesia
Authors: Marcos Martínez Tomás
Published: September 2021

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El desafío misionero hoy
Authors: Pandimakil G. Peter
Published: September 2021

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Ecología ¿ciencia o aguafiestas?
Authors: Rubio Carracedo Florentino
Published: September 2021

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La filosofía hispánica en el siglo XX (1898-1939)
Authors: Parrado Ávila Francisco Javier
Published: September 2021

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El diálogo
Authors: Vega Blanco José
Published: September 2021

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La cultura alternativa juvenil del “botellón”
Authors: Rubio Carracedo Florentino
Published: September 2021

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Observaciones sobre las nuevas Constituciones O.S.A.
Authors: Andrés Puente Heliodoro
Published: September 2021

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La primera edición castellana del Catecismo de Heidelberg (1627)
Authors: Resines Llorente Luis
Published: September 2021

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Nietzsche y el cristianismo
Authors: Maza Bazán Pedro
Published: September 2021

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Alrededor del Vaticano II
Authors: Marcos Martínez Tomás
Published: September 2021

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El aprendizaje de los sentidos
Authors: Vega Blanco José
Published: September 2021

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Teoría del perdón
Authors: Marcos Martínez Tomás
Published: September 2021

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Espiritualidad de la Regla de san Agustín
Authors: Luis Vizcaíno Pío de
Published: September 2021

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Ecclesia, mundus reconciliatus
Authors: Sánchez Rojas Gustavo
Published: September 2021

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Isabel la Católica, fiel hija de la Iglesia, y la hispanidad
Authors: Campo del Pozo Fernando
Published: September 2021

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Algunos aspectos de la educación
Authors: Vega Blanco José
Published: September 2021

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Age, growth, and mortality of littlehead porgy, Calamus proridens, from southeast Florida coastal waters
Authors: Burton Michael L , Potts Jennifer C , Poholek Ariel J , Page Jordan
Published: September 2021

Sectioned otoliths were used to age littlehead porgy Calamus proridens ( n = 737) from southeastern Florida recreational fisheries. Otolith sections contained easily identifiable annuli and were reliable structures for aging littlehead porgy up to 11 yrs. Opaque zones
were deposited from March to June (peaking in April). Littlehead porgy ranged from 1 to 11 yrs and 220 to 385 mm total length (TL). Body size relationships were TL = 1.09 FL + 16.06 ( n = 3474, r2 = 0.95), FL = 0.87 TL – 1.15 ( n = 3474, r2
= 0.95), W = 4.76 × 10 –5 TL 2.80 ( n = 6722, r2 = 0.86), and W = 1.2 × 10 –4 FL 2.71 ( n = 3474, r2 = 0.90), where W is total weight (g) and FL is
fork length (mm). Growth was not significantly different between two discrete geographic regions of Florida, and the von Bertalanffy growth equation was Lt = 335 (1 – e –0.41 ( t + 2.13) ) for all areas combined. The point estimate of natural
mortality was M = 0.38, while age-specific estimates of M ranged from 0.60 to 0.41 yrs–1 for ages 1–11. Littlehead porgy were fully recruited to the headboat fishery by age- 3 and catch curve analysis resulted in an estimate of total mortality Z
= 1.08 for ages 3–7+. This study reports first estimates of life history parameters for littlehead porgy from Atlantic waters of the southeastern United States.
Potential Investigation on Multiphase Flow of Loaded Dispersion for the Production of Metallized Paper
Authors: Suri Saadat Ullah Khan , Siddique Mohammad
Published: September 2021

The current review research's main objective is to develop dispersion models in the multilayer curtain coating with the production of metallized paper. To achieve this, the curtain coating on the paper substrate is employed with respect to multilayer coating of polymers. The first layer of polymer is applied to the paper and then it is subjected to vacuum metallization with aluminum deposition. After it, another second layer of polymer is subjected on it to prevent it from oxidation. These coated polymers are different in nature. The metallized paper will be produced which has high strength will be formulated in this application of curtain coating. The instability of curtain and air entrainment will be minimized from high Weber number, low Reynolds number, Optimum web speed and Coat weights. The above demonstrated process simulation will be modelled in Ansys-CFD. The dispersion of solids in the curtain flow through substrate moving on the web will be evaluated from different numerical methods. Each method has its own characteristics to study the nature of solids dispersion. The high loaded solids dispersion will be investigated from numerical methods including Langrangian Point Particle, Coarse grained molecular dynamics, Stokesian Dynamics, Brownian Dynamics, Point Particle Method Reynolds Averaged Navier Stokes equation, Eulerian Method, Langrangian-Eulerian Point Particle, Large Eddy Simulation point particle, Combined discrete element and Large Eddy Simulation and Discrete Element Methods.
Influence of Organizational Change on Public Health Maternal Health Care Service Delivery in Kitui County (A Survey of Level 4 Hospitals in Kitui County)
Authors: Syovinya Muteti Marinah
Published: September 2021

The County Governments in Kenya are faced with poor service delivery especially in the provision of maternal health care services. Maternal health care services in public hospitals are not meeting up to the quality standard as outlined by the Ministry of Health in Kenya. The paper sought to determine the influence of leadership and universal health coverage on public health maternal health care in Kitui County. This study was guided by Transformational Leadership Theory and Theory X & Y. The study focused on 11 public hospitals providing maternity services in Kitui County. The target population of the study was 203 health officers that include 26 doctors, 10 specialists, 41 clinical officers and 126 nurses across the 13 level 4 hospitals providing maternity services in Kitui County. Data was collected by use of structured closed ended questionnaire. Data analysis was conducted using SPSS Version 25.0 Software. Pearson Correlation showed that leadership and universal health coverage have a positive correlation with public health maternal health care service delivery. Model summary results indicated that leadership and universal health coverage explain 52.1 percent of public health maternal health care service delivery. Coefficient regression revealed that coefficient of leadership has appositive and significant influence (β=.203, p=.001<0.05) on and public health maternal health care service delivery. It was also found that coefficient of Universal Health Coverage and public health maternal health care service delivery have a positive and significant relationship (β=.662, p=.000<0.05). The study concludes that leadership is one of the key health systems factors affecting the performance of maternal health services at facility level. Conclusion can be made further that universal health coverage improves public health maternal health care service delivery. The study recommends for the need of maternal health care providers to review their leadership guidelines and styles with aim of enhancing quality of leadership in the management of hospitals. Though universal health coverage is on trial, the study recommends for the need to adequately support the implementation of universal health coverage.
Organizational and legal problems of execution of certain measures of penal impact, not related to deprivation of liberty
Authors: Красоткин Павел Николаевич , Шаклеина Алена Юрьевна
Published: September 2021

На основе анализа деятельности уголовно-исполнительных инспекций пяти регионов нашей страны, в которых проходят службу выпускники ФКОУ ВО Кузбасский институт ФСИН России, в статье рассматриваются организационные и правовые основы деятельности уголовно-исполнительных инспекций. Обоначены проблемы квотирования рабочих мест для трудоустройства осужденных к наказанию к исправительным работам; определен уровень нагрузки на инспекторский состав; исследована деятельность судов некоторых субъектов Российской Федерации; выявлены особенности исчисления нарушений в период испытательного срока условно осужденных; рассмотрены технические средства надзора и контроля, применяемые к осужденным к ограничению свободы; освещены проблемы исполнения обязанностей, способствующих исправлению условно осужденных. Предпринята попытка по разрешению некоторых проблем, обозначенных авторами. В статье предложены меры, направленные на ликвидацию выявленных проблем.

Based on the analysis of the activities of the penal inspections of five regions of our country, where graduates of the Kuzbass Institute of the Federal Penal Service of Russia serve, organizational and legal bases of activity of penal inspections are considered in article. So, the problems of quoting jobs for employment of convicts sentenced to correctional labor are emphasized; the level of load on the inspection staff is determined; the activities of courts of some subjects of the Russian Federation are investigated; the peculiarities of the calculation of violations during the probation period of conditionally convicted are revealed; technical means of supervision and control applicable to those sentenced to imprisonment are considered; the problems of performance of duties contributing to the correction of probationers are highlighted; untimely amendments to the current legislation regulating the activities of penal inspections are revealed. The authors made an attempt to resolve some of the identified problems. The article suggests measures aimed at eliminating the problems.
Characteristics of convicted persons who committed a crime with administrative prejudice
Authors: Берндт Анастасия Анатольевна
Published: September 2021

Предметом исследования является социально-демографическая характеристика осужденных за преступления с административной преюдицией. Целью исследования является анализ нового типа личности преступника-правонарушителя, особенностью которого является привлечение к уголовной ответственности за совершение нескольких аналогичных административных правонарушений. Основными методами исследования являются анализ, синтез, а также статистический метод. В результате исследования выявлены специфические социально-демографические характеристики осужденных за преступления с административной преюдицией, учет которых необходим для формирования системы профилактики такого противоправного поведения. Это невысокий уровень образования, возраст 30-49, преступления совершаются преимущественно мужчинами, за исключением преступлений, предусмотренных ст. 151 УК РФ, что объясняется сферой деятельности (сфера торговли), где преимущественно заняты женщины. Преступления совершаются трудоспособными лицами без определенного рода занятий, среди лиц, участвовавших в социально значимом труде, больше всего рабочих. Сделан вывод, что для выработки более точных мер превентивного воздействия на противоправное поведение преступника-правонарушителя необходим анализ социально-демографических характеристик не только осужденных, но и лиц, ранее привлекавшихся к административной ответственности.

The researching subject is the socio-demographic characteristics of those convicted of crimes with administrative prejudice. The purpose of the study is analyzing a new type of identity of the criminal offender, a feature of which is to bring to criminal responsibility for committing several similar administrative offenses. The main research methods are analysis, synthesis and the statistical method. As a result of the study, specific socio-demographic characteristics of those convicted for crimes with administrative prejudice were identified, which are necessary to form a system for the prevention of such unlawful behavior. This is a low level of education, age 30-49, crimes are committed mainly by men, with the exception of crimes under Art. 151 of the Criminal Code, which is explained by the sphere of activity (trade), where women are predominantly employed. Crimes are committed by able-bodied persons of a certain type of occupation; among those who participated in socially significant work, most are workers. The study concluded that in order to develop more accurate preventive measures on the unlawful behavior of the criminal offender, it is necessary to analyze of socio-demographic characteristics not only convicts, but also persons who were previously brought to administrative responsibility.
Some problems of exemption from criminal responsibility in connection with lapse of time
Authors: Черненко Тамара Геннадьевна
Published: September 2021

В статье анализируются дискуссионные положения об основании существования института давности привлечения к уголовной ответственности, приводятся аргументы в пользу вывода о том, что основание института давности заключается в отпадении либо ослаблении общественной опасности лица, совершившего преступление. Рассматриваются вопросы о начале исчисления срока давности применительно к преступлениям с материальным составом, длящимся, продолжаемым, преступлениям, а также преступлениям, совершаемым в соучастии. Поддерживается научная позиция относительно необходимости восстановления правила о прерывании течения срока давности привлечения к уголовной ответственности в случае совершения виновным лицом нового преступления. Обосновывается вывод о необходимости введения специальных давностных сроков для лиц, уклоняющихся от следствия или суда либо уплаты судебного штрафа, предлагается для указанных лиц предусмотреть увеличение наполовину сроков давности, предусмотренных в части первой статьи 78 УК РФ.

The article analyzes the controversial provisions on the basis of the existence of the institution of prescription of criminal prosecution, arguments in favor of the conclusion that the basis of the institution of prescription is to drop or weaken the social danger of the person who committed the crime. The questions of the beginning of the calculation of the Statute of limitations in relation to crimes with material composition, continuing, crimes, as well as crimes committed in complicity are considered. The scientific position on the need to restore the rule on the interruption of the Statute of limitations for criminal prosecution in the case of committing a new crime by the guilty person is supported. The conclusion about necessity of introduction of special limitation periods to persons evading investigation or trial or payment of court fines is proposed for these persons to provide for the increase of half-periods of limitation set out in part one of article 78 of the criminal code.
Interpretation and localization of Thorax diseases using DCNN in Chest X-Ray
Authors:   Department of Computer Science and Engineering, Amity School of Engineering and Technology, AUUP, Lucknow, India, Singhal Prateek
Published: September 2021

In recent years, the use of diagnosing images has been increased dramatically. An entry level task of diagnosing and reading Chest X-ray for radiologist but they ought to require a good knowledge and careful observation of anatomical principles, pathology and physiology for this complex reasonings. In many modern hospital’s the tremendous number of x-ray images are stored in PACS (Picture Archiving and Communication Sys-tem). The conditions of plethora been diagnosed by the sustainable number of chest X-Ray. Our aim to predict the thorax disease categories through deep learning using chest x-rays and their first-pass specialist accuracy. In a paper the main application that present a pathology localization framework and multi-label unified weakly supervised image classification that can perceive the occurrence of afterward generation of bounding box around the consistent and multiple pathologies. Due to considering of large image capacity we adapt Deep Convolutional Neural Network (DCNN) architecture for weakly-supervised object localization, different pooling strategies, various multi-label CNN losses and measured against a baseline of softmax regression.
PRIORITAS MASALAH DAN SOLUSI DALAM PROSES PEMBELAJARAN MAHASISWA PROGRAM STUDI AKUNTANSI
Authors: Rahardjo Yohana Ayu
Published: September 2021

This study aims to determine the priority of problems and solutions in the learning process in the SWCU FEB accounting study program. The data used in this study is primary data using respondents accounting class 2015, 2016, and 2017. The methods used in determining the priority of problems and priority solutions in this study using the Analytic Hierarchy Process (AHP) method. The results of the analysis show the priority of problems in the learning process is from the aspect of hard skills. Furthermore, the solution to the priority of hard skill problems is from the aspect of curriculum design. With a well-developed and appropriate curriculum design can be an effort to improve student hard skills.
Faktor-Faktor Yang Mempengaruhi Organizational Citizenship Behavior Pada Karyawan Swasta di Provinsi Yogyakarta
Authors: Kusuma Nala Tri , Wiyono Gendro , Lukitaningsih Ambar
Published: September 2021

Tujuan dari penelitian ini adalah untuk menguji perceived co-worker, perceived supervisior support, perceived organizational support, employee participation in decision making, career development, safety and health compliance pada job satisfaction dan organizational citizenship behavior. Metode yang digunakan dalam penelitian ini adalah metode kuantitatif dengan teknik accidental sampling. Hasil penelitian menunjukkan bahwa dukungan atasan yang dirasakan dan pengembangan karir memiliki pengaruh yang signifikan terhadap kepuasan kerja. Studi ini menemukan bahwa perceived co worker, perceived organizational support, employee participation in decision making, dan safety and helath compliance tidak berpengaruh pada job satisfaction. Hasil penelitian menunjukkan bahwa persepsi dukungan atasan, pengembangan karir, keselamatan dan kepatuhan kesehatan memiliki pengaruh yang signifikan terhadap organizational citizenship behavior. Penelitian ini menemukan bahwa dukungan rekan kerja, dukungan organisasi yang dirasakan, partisipasi karyawan dalam pengambilan keputusan, tidak mempengaruhi organizational citizenship behavior, dan hasilnya menunjukkan bahwa kepuasan kerja dimediasi antara pengembangan karir menuju perilaku kewarganegaraan organisasi.
Changes in health quality, lifestyle and habits in adolescents that induced by COVID-19 pandemic. Covid 19 lifestyle effect in adolescents
Authors: Solia Eirini , Filippou Dimitrios
Published: September 2021

Introduction: The Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) pandemic affected and altered several parts of our daily habits and lifestyle. Adolescents could not remain unaffected. Aim of the present study is to evaluate changes in health quality and daily habits of teenagers induced by the coronavirus disease 2019 (COVID-19) pandemic. Material and Methods: A detailed search of the literature was conducted in Pubmed to find published articles related to changes in health quality, lifestyle and habits in adolescents induced by COVID-19 pandemic.. Results: A total of 17 articles met our inclusion criteria and found suitable for our study. Additional resources provided useful information were also included. COVID-19 pandemic has caused changes in adolescents’ sleep habits and quality, such as increase in sleep duration and later bed time. Screen time increased but physical activity decreased. Moreover, eating patterns were altered and there was a tentionfor weight gain. Adolescents’ mental health and behavior were also affected, and in many cases negative feelings were arisen and mood symptoms were noticed. Conclusion: COVID-19 pandemic has unquestionably changed the adolescents’ everyday habits and lives. Considering that adolescence is the period in which physical and mental development of young people take place, we should keep in mind that the results of such effects might accompany them in their adult life.
Orthopaedic Surgery Residency Match After an Early-Exposure Research Program for Medical Students
Authors: Smolev Emma T. , Coxe Francesca R. , Iyer Sravisht , Kelly Anne M. , Nguyen Joseph T. , Fufa Duretti T.
Published: September 2021

Introduction:

The purpose of this study was to determine the proportion of students matching in orthopaedic surgery after a structured, early-exposure mentored research program and what factors were associated with those students compared with participants who matched in other specialties.

Methods:

Program data were reviewed from 2007 to 2015. Multivariable binary logistic regression analysis was used to evaluate student and research factors associated with orthopaedic surgery match.

Results:

Of 174 students, 117 (67%) matched into surgical residency programs, with 49% (n = 85) matching into orthopaedic surgery. The percentage of women matching into orthopaedic surgery (37%) was less than that of men (53%), which, however, increased over the study period. Students who matched in orthopaedic surgery had greater numbers of publications (3.55 [range 0 to 17] average publications) compared with students who matched in other specialties (1.98 (range 0 to 11) average publications). The average number of publications per student increased from 0.79 (±1.44, range 0 to 10, 40%) preprogram to 1.95 (±2.28, range 0 to 11, 71%) postprogram. Measured factors associated with orthopaedic surgery match were publications with program mentor, postprogram first authorship, and total publications.

Discussion:

Approximately half of the participants matched into orthopaedic surgery. Analysis showed that research productivity increased after program participation and was statistically associated with increased likelihood of orthopaedic surgery match.