bluuebunny/crossref_metadata_2025 huggingface dataset:
Changes in Temperature and Rainfall as a Result of Local Climate Change in Pasadena, California
Authors: Kimbrough David Eugene
Published: March 2018

The City of Pasadena is located in southern California; a region which has a Mediterranean climate and where the vast majority of rainfall occurs between October and April with the period between January and March being the most intense. A significant amount of the local water supply comes from regional rainfall, therefore any changes in precipitation patterns in the area has considerable significance. HYPOTHESIS: Local climate change has been occurring in the Pasadena area over the last 100 years resulting in changes in air temperature and rainfall. AIR TEMPERATURES: Between 1886 and 2016 the air temperature in Pasadena, California has increased significantly, from a minimum of 23.8°C in the daytime and 8.1°C at night between 1911 and 1920 to 27.2°C and 13.3°C between 2011 and 2016. The increase in nighttime temperature was uniform throughout the year, however daytime temperatures showed more seasonal variation. There was little change in the daytime temperatures May through July but more change the rest of the year. For example, the median daytime temperature for June between 1911 and 1920 was 27.9°C but was 28.7°C between 2011 and 2016, a difference of 0.8°C. In contrast, for October for the same periods the median daytime temperatures were 25.6°C and 28.9°C, a difference of 3.3°C. RAINFALL: There has been a change in local rainfall pattern over the same period. In comparing rainfall between 1883 – 1949 and 1950 – 2016, there appeared to be less rainfall in the months of October, December, and April while other months seemed to show no change in rainfall. For example, between the two periods mentioned above, the median rainfall in October was 12.4 mm and 8.9 mm respectively while for December they were 68.6 mm and 40.4 mm. There was comparatively a smaller change in the median volume of rainfall in April (18.8 mm vs. 17.5 mm). However, between 1883 and 2016 there were 13 with less than 1 mm of rain, 12 of which occurred after 1961. In the same line of logic, no measureable amount of rain occurred for 23 Octobers, 15 of those occurred after 1961. CONCLUSION: As air temperatures increased over the last 100 years in the Pasadena area, rainfall may have decreased in October, December, and April.
Microclimate Metrics Linked to the Use and Perception of Public Spaces: The Case of Chillán City, Chile
Authors: Smith Pamela , Henríquez Cristián
Published: March 2018

This paper presents a research carried out in the city of Chillan, a medium size city located on the southern limit of the Chilean Mediterranean domain, at 36º 36`s south latitude. Chillán provides a good representative example of warm summers in central and southern Chilean cities. Five public spaces were selected, representing different typologies and relating to different urban background conditions. Users in these public spaces were observed, counted and photographed five times a day (12, 14, 16, 18 and 20 hours, local time) during a heat wave event in the summer of 2016, while meteorological parameters were established at different points within the public space. The variables evaluated were impervious surfaces, Skyview factor, H/W, azimuth, shadow and radiation. Local public environmental management should pay attention to the complex relations between urban climate, public spaces and thermal comfort since they affect the quality of life of the most vulnerable sectors of the population. This is particularly important given the increasing episodes of high temperatures and intense heat waves occurred in the city of Chillán in recent summers, which are related to urban heat islands and climate change.
Öğrenci, Öğretmen ve Öğretimsel Nitelikler Açısından TIMSS-2015’e Dayalı Olarak Öğrencilerin Sınıflandırılması
Authors: ÖNEN Emine
Published: March 2018

Bu araştırmanın amacı, TIMSS-2015
uygulamasına dayalı olarak, matematik başarısını etkileyebileceğini düşünülen
öğrenci ve öğretmen nitelikleri ile öğretimsel nitelikler açısından dördüncü ve
sekizinci sınıf öğrencilerini sınıflandırarak öğrenci profilleri oluşturmaktır.
Yapılan kümeleme analizi sonucunda dördüncü sınıf düzeyinde üç kümenin ortaya
çıktığı, sekizinci sınıf düzeyinde ise iki kümenin ortaya çıktığı gözlenmiştir.
Dördüncü sınıf düzeyi için bu kümelerin oluşmasında en etkili olan özellikler,
matematik başarısı, öğrenci ve öğretmen nitelikleridir. Öğretmen beyanına
dayalı belirlenen öğretimsel niteliklerin sınıflama işleminde çok az önemli
olduğu bulunmuştur. Sekizinci sınıf düzeyi için ise öğrenci niteliklerinin bu
sınıflamada en etkili faktörler olduğu ancak matematik başarısının ve öğretmen
nitelikleri ile öğretimsel niteliklerin, öğrencilerin sınıflanmasında düşük düzeyde
önemli olduğu görülmüştür. Tanımlanan öğrenci profilleri, öğrenci nitelikleri
açısından her iki sınıf düzeyinde de benzerlik gösterirken; öğretmen
nitelikleri ve öğretimsel nitelikler açısından dördüncü ve sekizinci sınıf
düzeyi için farklılaşmaktadır. Her iki sınıf düzeyinde de matematikte en
başarılı öğrencilerin matematikte kendine güven düzeyi çok düşük, matematik
öğrenmeyi seven, matematik dersindeki öğretimin ilgi çekici olduğunu düşünen,
okula aidiyet hissi yüksek ve akran baskısına çok az maruz kalan öğrenciler
olduğu gözlenmiştir. Matematikte başarı düzeyi düşük öğrencilerin ise
matematikte kendine çok güvenen, matematik öğrenmeyi sevmeyen, matematik
dersindeki öğretimi ilgi çekici olmadığını düşünen, okula aidiyet hissi düşük
ve akran baskısına maruz kalan öğrenciler olduğu görülmektedir.
New Method for Enhanced Continuous Circulation Automation
Authors: Johnson Rachel , Milne Adam , Molaschi Claudio
Published: March 2018

The introduction of continuous circulation technology during the drillpipe connection process pioneered by Eni with the introduction of the Eni Circulation Device (e-cd™) has helped address many difficult drilling challenges by providing a simple managed pressure drilling (MPD) solution for many narrow pressure gradient, high-pressure/high-temperature (HP/HT), and extended reach horizontal wells.

Increasingly, rigs using continuous circulation hold the requirement that all personnel be removed from the rig floor red zone area during single-pressure barrier exposure applications. To address this challenge, a new and enhanced semiautomated connection system was developed that enables an operator to deliver a connection tool to the continuous circulation sub by overhead lift or manipulator arm. Using a remote human machine interface (HMI), the system automatically removes a threaded cap, makes a flowline connection to the side port, automates the flow diversion process while a new stand is connected, and isolates the side port once the connection and flow diversion process is complete—all without the operator’s physical interaction.

The new system removes personnel from single-barrier pressure environments, helping improve safety to rig floor personnel and, because of the addition of automation, increasing system performance and repeatability to reduce nonproductive time (NPT) and rig drilling days.
Managed Pressure Drilling Optimized Design and Future Strategy
Authors: Custer Jason , Kuilenburg Robert van , Johnson Austin , Hovland Svein
Published: March 2018

With current offshore drilling tenders limited to small durations and high Managed Pressure Drilling (MPD) equipment rental costs, a team of industry partners has embarked on an innovative, cost effective, and efficient approach to upgrade a drilling fleet to be "MPD Ready". The core of this new approach is an integrated MPD package that can be transferred from rig to rig with minimal time and effort; while sharing the cost of the MPD equipment across multiple wells and/or rigs. With rig integration piping already installed on multiple vessels, the integrated MPD package can be installed as "plug and play" modules allowing multiple rigs in the same region to be "MPD Ready" within days. For a four rig program cost savings of over 50% are possible on initial investment cost. To further the cost effectiveness of MPD, the parties are working together to integrate the drilling control system with the MPD control system, further enhancing the efficiency of rig operations. The drilling control system will incorporate a functionality to automate any procedure and will be able to seamlessly work with a variety of other programs such as hydraulic models. Recognizing the importance of well trained crews, developing a training program that teaches the rig personnel how to operate and maintain the equipment has been integral to this MPD approach. This program paired with the equipment manufacturer bringing rig personnel into their facilities to facilitate hands on maintenance and operation training will provide the crews with confidence to run the MPD package effectively. In doing this, the overall number of crew required to operate and maintain the MPD equipment will be drastically reduced.
Utilizing a Fully Automated MPD System to Run and Cement 9-5/8 in. Liner String in HPHT Gas Wells
Authors: Aljubran M. J , Oqaili A. H. , Ezi P. C. , Iturrios C. O.
Published: March 2018

The field of interest involves penetrating a predominantly dolomite and dolomitic limestone formation associated with highly pressurized saltwater equivalent to as high as 157 pcf (21 ppg). The most over-pressurized zones are encountered across the ±1,000 ft. base layer of this formation where the majority of flow incidents occurs. This is further exacerbated by the extremely narrow mud window of 0.5-1.0 pcf (0.07-0.14 ppg) between the pore pressure and fracture pressure. Such conditions may lead to risky operations that include well control, high mud weight (MW) design complications, differential sticking, drillstring design limitations, liner equipment failure, poor cement job, etc.

Fully automated managed pressure drilling (MPD) systems are utilized to drill the 12 in. hole section and walk the tight window across this rock. This approach allows for applying surface back-pressure (SBP) and accurately holding constant bottomhole pressure (BHP) while keeping constant MW throughout the drilling operation. This operation also witnessed the application and utilization of fully automated MPD systems as means to run and cement a 9-5/8 in. liner across this troublesome zone.

Conventionally running liners in excessively high kill MW of ±155 pcf (20.72 ppg) while dealing with tight margins is particularly challenging as it yields total losses due to the surge effect. Conventional cement jobs also mandate filling the hole with high kill MW before the cementing operation, inducing losses and resulting in poor well integrity, leaking liner packer, wet casing shoe, etc. Utilizing MPD systems to run and cement the 9-5/8 in. liner allowed for multistage hole displacement, filling the hole with a lighter MW, and maintaining constant BHP throughout the entire operation regardless of any surface tool failure (pump cavitation, leaking cement head, and surface lines, etc.).

This paper details the planning and design phase along with the operational sequence of running and cementing the 9-5/8 in. liner with fully automated MPD systems. A case study will be highlighted to establish lessons learned and best practices.
Using Real Time Fluid Properties Data in Providing Accurate Results for Managed Pressure Drilling and Improved Drilling Control
Authors: Elyas Odai , Alyami Abdullah , Algharbi Salem , Aljubran Mohammad
Published: March 2018

Narrow mud windows often cause a lot of trouble when using conventional drilling techniques due to the difficulty of maintaining the bottomhole pressure between the maximum pore pressure and minimum fracture pressures of the exposed formations. This can lead to wellbore influx, formation damage and fluid loss. Managed pressure drilling (MPD) is an adjustable drilling technique that will help balance and maintain the annulus pressure, within a desired margin. Using MPD will enhance drilling performance, reduce nonproductive time (NPT), and increase safety.

Operators usually acquire fluid property measurement by either PVT analysis to account for downhole effect of pressure and temperature on density and rheology, or using experimental lab data with downhole fluid properties. These measurements are used to calculate the equivalent circulating density, and control surface back pressure (SBP) via MPD surface choke.

Acquiring real-time downhole data for fluid properties like density and rheology, at a high frequency, will lead to precise calculations of the equivalent circulating density (ECD), and the annular frictional losses. Real-time monitoring of ECD and pressure drop allows for optimal control over the annular pressure throughout the drilled section, which in turn reduces the risk of kick occurrence and lost circulation.

Satisfactory results were achieved with the use of real-time data in MPD; where no stuck pipe or well control incidents were recorded. In this paper, we will demonstrate the steps taken to obtain real-time data measurements of the properties and the operational details that led to improved performance of MPD.
Dual-Gradient Drilling of Deepwater in South China Sea: What is the Well's Maximum Measured Depth and How to Improve It
Authors: Li Jun , Zhang Hui , Li Xin , Ding Shidong , Tao Qian
Published: March 2018

In order to make extended-reach drilling (ERD) of deepwater cost-competitive and obtain the maximum reservoir contact, dual-gradient drilling (DGD) technology is more and more used in offshore drilling. In this study, a method to predict the maximum measured depth (MMD) of the offshore horizontal well by DGD method in deepwater is presented. The prediction model is established based on the dynamic pressure balance of bottom hole. Two prediction models of offshore horizontal well's MMD by subsea mudlift drilling (SMD) method and hollow glass spheres (HGS) method are analyzed and established respectively. Moreover, effects of flow behavior index, consistency coefficient, drilling fluid density and ROP on these predicted MMDs with two DGD methods are analyzed. Finally, an offshore horizontal well in the South China Sea is analyzed. Some optimization measures are also put forward to obtain higher MMD and maximize reservoir contact. The study shows that there is a decrease of the predicted MMD as the flow behavior index, consistency coefficient and ROP are increased. Moreover, effects of drilling fluid density on the predicted MMD with different drilling methods are also analyzed. It shows that the ERW's MMD first increases and then decreases with the increase in drilling fluid density. It also shows that DGD method is conducive to expanding the MWW of horizontal well in deepwater. This work provides a practical tool for predicting the horizontal well's MMD of DGD in deepwater and achieving greater MMD. The study is significant to maximize reservoir contact and obtain good economic benefits of oil and gas development in deepwater.
First Field Use of Electric Roller Screw Actuated Choke Designed for Managed Pressure Drilling
Authors: Parker Martyn , Nauduri Sagar , Spahn Micah , Klemetson Ryan
Published: March 2018

Automatic and remote operated drilling chokes have been in the petroleum industry for a very long time. Managed Pressure Drilling (MPD) operations have been using these chokes since ±2006 and prior to that Underbalanced Drilling (UBD) operation have been using them for decades. The main control or actuation of these drilling chokes is achieved by adapting standard API-16C hydraulic or electric actuated worm gear drive actuators. These methods of actuation however have limitations related to ‘Response Time’ and ‘Equipment Failure', making these actuators less desirable for MPD applications.

An advanced method of actuation using ‘Electro Servo Actuator’ is presented as an alternative to alleviate these challenges. These electro servo actuators are designed from the outset considering the requirements of MPD Choke operations, and are optimized to provide precise control of chokes along with a reduction in the number of potential failure points.

During extensive laboratory testing, required as a quality standard for our MPD choke's factory acceptance program, these actuators provided very accurate and responsive pressure control to quick changes in pressure demands based on variations in both set point and flow. Furthermore, the initial field testing of the actuator in the MPD field operations demonstrated the same precise and accurate pressure control tracking, along with better performance at ‘lower flowrates’ when compared to worm gear driven chokes. Full-scale field application on over 20 different projects across North America, including a wide range of severe weather conditions, exceeded the expectations and results from initial testing.

In conclusion, the use of this new ‘Electro Servo Actuator’ technology greatly increases the precise control of drilling chokes very crucial for all MPD applications. This technology reduces the potential failure points in the actuators. It enhances the uptime of the actuator and its life cycle, thereby minimizing the need for routine maintenance. Its smaller size and design enables development of more compact MPD chokes and equipment.
Natural Approaches in Diabetes Management: A Review of Diet, Exercise, and Natural Products
Authors: Schultz William M. , Varghese Tina , Heinl Robert E. , Dhindsa Devinder S. , Mahlof Elliot N. , Cai Hannah C. , Southmayd Geoffrey , Sandesara Pratik B. , Eapen Danny J. , Sperling Laurence S.
Published: March 2018

Diabetes mellitus (DM) is a highly prevalent condition that causes significant morbidity and mortality
in the United States and worldwide. Conventional therapies include lifestyle modification, oral pharmacological
agents, and subcutaneous insulin. Emerging data suggest that natural approaches to the treatment of DM may help
supplement current therapies for further glycemic control. Herein, we review the evidence of several natural
modalities for DM treatment. We describe the pathophysiology of diabetes and its complications, provide an
overview of current pharmacologic treatments, and finally, discuss natural approaches to diabetes management.
Specifically, we will describe on the utility of diet, physical activity, and common natural products in the treatment
of DM and focus on recent, high-quality studies. Adverse effects and potential interactions of each therapy
will be highlighted where applicable.
New Benzodioxole-based Pyrazoline Derivatives: Synthesis and Anticandidal, In silico ADME, Molecular Docking Studies
Authors: Özdemir Ahmet , Sever Belgin , Altıntop Mehlika Dilek
Published: March 2018

Background:

Azoles are commonly used in the treatment and prevention of fungal
infections. They suppress fungal growth by acting on the heme group of lanosterol 14α-demethylase
enzyme (CYP51), thus blocking the biosynthesis of ergosterol.

Objectives: Due to the importance of pyrazolines in the field of antifungal drug design, we aimed to
design and synthesize new pyrazoline-based anticandidal agents.

Methods:

New pyrazoline derivatives were synthesized via the reaction of 1-(chloroacetyl)-3-(2-
thienyl)-5-(1,3-benzodioxol-5-yl)-2-pyrazoline with aryl thiols. These compounds were evaluated
for their in vitro antifungal effects on Candida species. Docking studies were performed to predict
the affinity of the most effective anticandidal agents to substrate binding site of CYP51. Furthermore,
MTT assay was performed to determine the cytotoxic effects of the compounds on NIH/3T3
mouse embryonic fibroblast cell line. A computational study for the prediction of ADME properties
of all compounds was also carried out.

Results:

Compounds 5, 8, 10 and 12 were found as the most potent anticandidal agents against
Candida albicans and Candida glabrata in this series with the same MIC values of ketoconazole
and they also exhibited low toxicity against NIH/3T3 cells. Docking results indicated that all these
compounds showed good binding affinity into the active site of CYP51. In particular, chloro
substituted compounds 8 and 12 bind to CYP51 through direct coordination with the heme group.
According to in silico studies, compound 8 only violated one parameter of Lipinski’s rule of five,
making it a potential orally bioavailable agent.

Conclusion:

Compound 8 was defined as a promising candidate for further in vitro and in vivo
studies.
Research Progress of Natural Polymers in Wastewater Treatment
Authors: Li Xiang , Yang Baojun , Feng Li , Zheng Huaili , Zeng Guoming , Wu Pei
Published: March 2018

With the development of industry, urbanization, increasingly stringent environmental protection
requirements, and strengthening of people’s environmental awareness, green treatment of pollutants
has become a research hotspot in the field of environmental protection. Accordingly, the study on natural
non-toxic polymers has received increasing attention from researchers. This paper aims to provide
the present research progress of natural polymers in environmental engineering, including the striking
characteristics and modification methods of the most well-known natural polymers, as well as their applications
in environmental protection field. Concluding remarks and future trends are also pointed out.
The Challenges of Climate Change and Food Security in the United Arab Emirates (UAE): From Deep Understanding to Quick Actions
Authors: Ajaj Rahaf M. , Shahin Suzan M. , Salem Mohammed A.
Published: March 2018

Climate change and global warming became a real concern for global food security. The world population explosion is a critical factor that results in enormous emissions of greenhouse gasses (GHGs), required to cover the growing demands of fresh water, food, and shelter. The United Arab Emirates (UAE) is a significant oil-producing country, which is included in the list of 55 countries that produce at least 55% of the world’s GHGs and thus involved in the top 30 countries over the world with emission deficits. At the same time, the UAE is located in an arid region of the world, with harsh environmental conditions. The sharp population increases and the massive growth in the urbanization are primary sources, lead to further stresses on the agricultural sector. Thus, the future of the food production industry in the country is a challenging situation. Consequently, the primary objective of this work is to shed light on the current concerns related to climate change and food security, through describing the implications of climate change on the food production sector of the UAE. Tailored solutions that can rescue the future of food security in the country are also highlighted.
Identifying the Optimal Fractionation Schedules for Improved Response Rates and Survival in Patients with Metastatic Melanoma Treated with Ipilimumab and Radiotherapy
Authors: Liu Jason , Xu Cong , Zhu Junjia , Sivik Jeffrey , Drabick Joseph J. , Mackley Heath B.
Published: March 2018

Objective:

There is a growing body of evidence that combining ipilimumab with higher
doses of radiotherapy may improve the response rates and survival in patients with metastatic melanoma
compared to lower doses of radiotherapy. However, the dose cutoff at which improved outcomes
are more likely to occur has not been properly identified.

Methods:

We conducted a retrospective analysis of 100 patients treated with ipilimumab and radiotherapy
for metastatic melanoma at a single institution from May 2011 to January 2017. Demographic,
clinical, and treatment factors, including the biological equivalent dose (BED) with an α/β
of 7, were recorded. Endpoints of interest included infield and global complete response (CR) after
the completion of radiation and ipilimumab based on the RECIST criteria (v1.1) and 12-month
overall survival (OS).

Results:

The BED cutoffs at which improved outcomes are more likely to occur are 46.5 Gy for infield
CR, 50.9 Gy for global CR, and 46.5 Gy for 12 month OS. The least aggressive fractionation
schedules used in this patient population that have a BED above the threshold for all 3 outcomes include
40 Gy in 20 fractions, 30 Gy in 6 fractions, and 24 Gy in 3 fractions.

Conclusion:

This hypothesis-generating study suggests that patients who cannot receive ablative intent
radiotherapy may be more likely to benefit from concurrent radiotherapy with ipilimumab if
their fractionation schedule has a BED above 46.5 - 50.9 Gy. Prospective trials evaluating this question
should be considered.
ANALYSIS OF ENVIRONMENTAL CONDITIONS IN METAL INDUSTRY
Authors: Kahya Emin , Ulutaş Berna , Özkan N. Fırat
Published: March 2018

Environmental conditions have an essential importance
in terms of occupational health and productivity in each sector. However, it is
very difficult to keep environmental conditions within the specified ideal
limits due to the processes carried out in the metal industry. Evaluating the environmental
conditions constantly, defining precautions, and linking the consequences are critical
to improve productivity of workers who work under improper conditions under
time pressure. In this study aims to investigate the levels of critical
environmental conditions such as heat, humidity, noise, and illumination for
the metal industry in Eskisehir. An observation form is designed to record the
data and a total of 92 measurements are taken for eight facilities that use
sheet-metal forming machines such as hydraulic press, eccentric press, lathe,
and guillotine shear. The analyze results of the data state that the temperature
is 16.22-29.74 ° C (avg. 23.99 ° C), 22.99% to 54.92% (avg. 36.35), and the
noise level 82.3-110.3 dB (A) (avg. 91.88 dB (A)) and the illumination is
33.2-902.7 lux (avg. 289.34 lux) for the facilities in concern.
AN INVESTIGATION ON MODELING OF DALAMAN STREAM FLOWS BY USING WAVE-ANFIS
Authors: TAYLAN Dilek
Published: March 2018

The object of the study is to investigate a flow estimation
model by using a combination of Wavelet Transform Technique (W) and Adaptive Neural
Based Fuzzy Inference System (ANFIS). Many models has been applied in recent
years for the prediction of Dalaman Stream flow in the south of Turkey. One of
these studies was AR-ANFIS models which developed by Taylan (2008), its
training data set was extended with synthetic series produced by autoregressive
processes. In this study, W-ANFIS models were developed with sub-series
generated by wavelet analysis by using extended training set of ANFIS models.  It is seen that increasing the number of
input data in training increases model performance. Compared with the developed
models, it has been shown that the W-ANFIS hybrid models have a better
predictive power than the AR-ANFIS models. Consequently, the W-ANFIS hybrid
model could be used successfully in predicting of flow.
A NEW ROBUST QRS DETECTION ALGORITHM IN ARRHYTHMIC ECG SIGNALS
Authors: BILGIN Süleyman , AKIN Zahide Elif
Published: March 2018

The QRS detection in electrocardiogram (ECG) signals
provides significant information to help automatic diagnosis of some
cardiovascular disorders. There are many studies about QRS detection in the
literature. All these studies have focused on the development of QRS detection including
noise, baseline wander, artifacts, small and wide QRS complexes. However, some
QRS complexes cannot be detected due to their morphological and arrhythmic
disorders. These types of beats are misevaluated during observation. Therefore,
increasing the success and accuracy of such algorithms is of great importance
for the development of wearable cardiac diagnostic devices. Arrhythmic ECG
signals include different morphologic features, such as sudden, narrow, small,
and negative QRS complexes, which are very difficult to automatically detect. In
this study, we propose a new algorithm with higher accuracy than other studies
in the literature for the detection these types of QRS complexes. The proposed
method based on digital filtering and Discrete Wavelet Transform (DWT) is
evaluated and tested using the two-channel ECG records obtained from 48
patients in the MIT/BIH arrhythmia database. The overall performance results of
this algorithm are calculated as 99.79% of the sensitivity, 99.95% of the
predictivity rate, the detection error rate of 0.26 and 99.74% of accuracy score.
Strategi Pemasaran Berbasis Media Sosial bagi Pengrajin Batik
Authors: Sayogo Djoko Sigit
Published: March 2018

Penelitian ini bertujuan untuk mengimplementasikan strategipemasaran berbasis media sosial bagi pengrajin Batik diDolokgede, Bojonegoro. Penelitian mengkombinasikanwawancara, observasi dan analisa dokumen sebagaimetodologi untuk mengidentifikasikan permasalahanpengrajin, menentukan kebutuhan konsumen/potensikonsumen dan merancang tindakan strategis yang dapatdilakukan pengrajin Dolokgede untuk menggunakan mediasosial sebagai penunjang pemasaran produk mereka.Berdasarkan hasil wawancara dan observasi kamimengusulkan penggunaan Facebook sebagai alat untukpenunjang pemasaran dengan tiga tujuan: a) meningkatkanjumlah basis ―anggota (teman)‖ dalam laman Dolokgede, b)meningkatkan reputasi merek produk melalui komunitas―anggota (teman)‖, dan c) melakukan update kegiatanpengrajin ke komunitas ―anggota (teman)‖. Untuk itu, kamimengusulkan 4 rencana tindakan strategis pemasaran, yaitu: a)memposting konten tentang aktivitas kerja mereka sehari-haridalam bentuk cerita (story), b) meng-audit dan update lamanfacebook secara berkelanjutan, c) meningkatkan ―like‖ dankomentar melalui posting konten interaktif dan d)meningkatkan keterlibatan komunitas ―anggota (teman)‖.
IBM DUSUN SUKOSARI DESA PANDANSARI PONCOKUSUMO KABUPATEN MALANG
Authors: Latifah Sri Wahjuni
Published: March 2018

Pengabdian masyarakat ini dilakukan di Dusun Sukosari Desa Pandansari Poncokusumo Kabupaten Malang. Dusun ini memiliki sumber daya alam yang banyak namun akibat bencana gunung Bromo tidak lagi menghasilkan sebagaimana biasanya. Perkebunan hanya mengandalkan air hujan sehingga banyak waktu yang terbuang dari para petani atau masyarakat pada umumnya. Berdasar identifikasi masalahnya ditemukan bahwa mitra memiliki pengetahuan yang rendag tentang pengelolaan sumber daya alam. Disamping itu motivasi dan pengetahuan tentang wirausaha juga rendah. Akibatnya terjadi penurunan nilai ekonomi masyarakat. Solusi yang ditawarkan adalah penyuluhan, sosialisasi dan diskusi dengan mitra. Hasilnya adalah mitra dapat memahami pengelolaan sumber daya sesuai dengan potensi dan skill masyarakat, serta mitra dapat menganalisis kelayakan usaha yang akan dikembangkan menjadi usaha bersama.
GÜRCİYEF METODUNDA MÜZİK UYGULAMALARI VE PİYANO MÜZİKLERİNİN TEMEL ÖZELLİKLERİ
Authors: BİRGÜL AKÇAKMAK Hale
Published: March 2018

20. yüzyılın başında Batı dünyasına sanat uygulamaları

odaklı bir öğreti sunan Gürciyef, müziklerinde birçok farklı kaynaktan

yararlanmıştır. Müzik yazma sürecinin dinleyici önünde gerçekleştiği ve pratik

alanda yapılan çalışmaların parçası olan müzikler özgün bir dile sahiptir.

Batı’ya sunulan üretimler olan müziklerde kullanılan çok çeşitli malzeme ve

sembolik içerik, kategorize edilmesi güç niteliklere sahiptir. Tüm inançlara mesafeli, evrensel bir

üst insan modelini hedefleyen metodun aynı zamanda ciddi bir modernizm

eleştirisi ile kurduğu sıradışı, zaman zaman tutarsız ve kışkırtıcı dilinin

derin sembolik araçları, çok sonra çözümlenmeye değer bulunmuştur. İnsanın bedensel,

zihinsel ve duygusal uyumunu hedefleyen metot bağlamında yapılacak okumalarla

içerik kendini görünür kılmaktadır. Müzik dışı eğilimlerin öne çıktığı beden deneyimi

odaklı uygulamalar, insan algısının farklı biçimlerini hedeflemesi bakımından

incelemeyi bekleyen bir alan olma özelliğini günümüzde de sürdürmektedir.

Müzikler ve metodun ilişkisini kavramaya yönelik bir bakış açısı geliştirmeyi

hedefleyen bu araştırmada, Gürciyef metodunda müziğin kullanımının nedenleri ve

müzik malzemesinin temel özellikleri araştırılırken Gürciyef’e ait metinler

temel kaynak olarak kullanılacaktır.
O adestramento positivo como tratamento em cães com distúrbios comportamentais de ansiedade: Relato de casos
Authors: Linhares Virna Livia , Silva Michelle Costa e , Silva Aline Maia , Bezerra Diana Romão
Published: March 2018

The interaction between the human and canine species is increasingly increasing and there is a strong link between both species. This relationship, in addition to bringing benefits, can also bring harm and harm animal welfare. Behavioral problems are caused by a series of factors whose roots lie in interactions with the guardian and lack of knowledge about the canine species and their needs, which directly affect the animal's quality of life and weaken the man-dog relationship. In this sense, the objective of this study is to understand positive dog training in addition to the basic commands, understanding it as a way of raising awareness and education of the family about the real needs of the canine species, promoting well-being, an effective way to treat behavioral anxiety disorders. In the methodology, behavioral assessments and positive training techniques were used systematically, together with the family-animal-environment triad, in order to reduce and modify the negative behaviors of the animals. The results were positive, since the animals responded well to the proposed exercises, with the greatest difficulty being the engagement of the tutor in behavioral therapy, as well as the commitment on the responsibility of daily animal education; it is noted that the owner represents both the triggering element of the problem and the therapeutic agent. It can be concluded from this work that positive dog training is quite effective in the treatment of behavioral anxiety disorders, for promoting well-being, the best healthy relationship of animals with their guardians, the environment that surrounds them and the interaction with other people and animals. Because it is a behavioral treatment, execution time is necessary to obtain lasting results. However, the family's awareness and education regarding respect for canine behaviors, their needs and temperaments is also necessary so that there is no stress in the relationship that can trigger anxiety disorders.
Erliquiose monocítica canina: Relato de Caso
Authors: Goulart Rones , Almeida Arleana do Bom Parto Ferreira de , Sousa Valéria Regia Franco , Almeida Rodrigo Delbem
Published: March 2018

Canine monocytic ehrlichiosis is an infectious disease of worldwide distribution, caused by Ehrlichia canis and transmitted by Rhipicephalus sanguineus, resulting in mild to intense signs or absence, depending on the stage of the disease. The diagnosis can be made by serology, research hematozoa and molecular techniques like Polymerase chain reaction (PCR). The aim of this study is to report the case of a Bitch Boxer, 12 years old, with hyperthermia, tachypnea, stridor, and petechiae, being submitted to additional tests, that demonstrated thrombocytopenia, hyperproteinemia and increased AST and ALT; the diagnosis was established by associating these results with PCR positive for E. canis; Doxycycline was used for the treatment, and after completion, the patient returned for reassessment, being PCR negative from peripheral blood sample. We suggest a new PCR from samples of bone marrow or spleen, because from peripheral blood it may result in false negatives.
Sugar-Sweetened Beverage Intake Assessment in a Family Medicine Residency Clinic
Authors: Neme Jamil , Nirmalraj Maya , Matthews Haley , Geske Jenenne , Khandalavala Birgit
Published: March 2018

Introduction: Sugar-sweetened beverages (SSBs) are a major source of added calories in the American diet, with significant adverse health outcomes. However, intake of SSBs is not commonly assessed in the clinical setting. In some populations with health disparities there is a higher consumption of caloric beverages, contributing to increased cardiometabolic risk. Family medicine residency clinics often provide services for the underserved population, and may encounter additional barriers in nutritional assessment.
Methods: Our study, conducted at a residency clinic in Omaha, Nebraska, utilized the abbreviated Beverage Intake Questionnaire 15 (BEVQ-15). We surveyed 310 patients over a 3-month period.
Results: Consumption of SSBs in our sample was significantly higher than that of the nonclinic population of Nebraska (P<0.001). Fifty-six percent of resident clinic respondents reportedly consumed at least one SSB daily, resulting in an average intake of 244 kilocalories. Intake was significantly higher in males, younger patients, those with lower socioeconomic status, and Latinos. While the majority of the study population was obese, there was no direct correlation between weight and SSB intake. The survey required less than 3 minutes to complete. Future interventions may focus on reduction of SSB intake and promotion of water consumption.
Conclusions: Assessment of SSB intake in a family medicine residency clinic can be easily conducted, providing opportunities for clinical providers to suggest patient-specific modifiable behaviors. As the obesity epidemic continues to progress, point-of-care intervention to reduce SSB consumption may help reduce cardiometabolic risk and improve health outcomes.
DISCUSSION OF: Economic Analysis of Proposed PCAOB Standards: Finding a Path Forward
Authors: Ramamoorti Sridhar
Published: March 2018

SYNOPSIS

For organizing my discussant response, I use the “input-process-output-outcomes” framework, where the PCAOB is part of the standard-setting infrastructure (input), the processes are its standard-setting activities, the standards eventually developed and approved by the SEC (the output), and assessing the outcome(s) refers to evaluating how well the PCAOB is achieving its mission and vision. From this perspective, Nolder and Palmrose's (2018) critique of the PCAOB's standard-setting pace as being “glacial” can only be regarded an “operational criticism.” In fact, viewed in light of the recently released Monitoring Group's (2017) Consultation paper, the PCAOB actually appears to be ahead of the IAASB as a much more independent and active standard-setter. Expanding the PCAOB's “economic analysis” to incorporate behavioral disciplines could certainly make the rationale more grounded and stronger, but will likely further slow down the pace of standard-setting—a result that goes against the authors' preference. Beyond just behavioral approaches, I consider the even broader perspective of “political economy” in this context and highlight the relevance of Ashby's Law of Requisite Variety (Ashby 1956) as an overarching framework. Toward the end, I support certain arguments made by Nolder and Palmrose (2018), and in particular commend their suggestion that the PCAOB develop a conceptual framework for standard-setting going forward.
SDF-1 Is an Autocrine Insulin-Desensitizing Factor in Adipocytes
Authors: Shin Jihoon , Fukuhara Atsunori , Onodera Toshiharu , Kita Shunbun , Yokoyama Chieko , Otsuki Michio , Shimomura Iichiro
Published: March 2018

Insulin desensitization occurs not only under the obese diabetic condition but also in the fasting state. However, little is known about the common secretory factor(s) that are regulated under these two insulin-desensitized conditions. Here, using database analysis and in vitro and in vivo experiments, we identified stromal derived factor-1 (SDF-1) as an insulin-desensitizing factor in adipocytes, overexpressed in both fasting and obese adipose tissues. Exogenously added SDF-1 induced extracellular signal–regulated kinase signal, which phosphorylated and degraded IRS-1 protein in adipocytes, decreasing insulin-mediated signaling and glucose uptake. In contrast, knockdown of endogenous SDF-1 or inhibition of its receptor in adipocytes markedly increased IRS-1 protein levels and enhanced insulin sensitivity, indicating the autocrine action of SDF-1. In agreement with these findings, adipocyte-specific ablation of SDF-1 enhanced insulin sensitivity in adipose tissues and in the whole body. These results point to a novel regulatory mechanism of insulin sensitivity mediated by adipose autocrine SDF-1 action and provide a new insight into the process of insulin desensitization in adipocytes.
A case of functional hypoparathyoidism due to hypomagnesaemia leading to hypocalcaemic seizures
Authors: Aquilina Neville , Bugeja Vincent , Bugeja George
Published: March 2018

This case report describes an elderly lady who was maintained on a high dose of loop diuretics following resolution of her acute pulmonary oedema, which in turn led to wasting of calcium and magnesium at the nephron level. Her hypomagnesaemia further contributed to the hypocalcaemia by rendering ineffective the normal parathyroid negative feedback physiological response. This state of low calcium increased the neuromuscular excitability leading to myoclonic epilepsy which was resistant to benzodiazepines. Such hypocalcaemic tetany in this case would only be adequately addressed once the magnesium levels are repleted, as this would allow the parathyroid mechanism to function effectively and redress the calcium level as a result.
SOME ASPECTS OF TRANSITION TO THE SUSTAINABLE DEVELOPMENT OF ECONOMIC SYSTEMS IN MESO- AND MACRO-LEVELS
Authors: Bataeva Bela Saidovna , Avadaeva Inna Vladimirovna , Goldenova Victoria Sergeevna , Mantaeva Elza Ivanovna
Published: March 2018

Against the backdrop of the growing influence of economic processes on the environment, the trend of the reverse effect of ecology on the economic activity is becoming more and more evident. The so-called concept of sustainable development has become one of the most important factors in modernizing the national economy. The emergence of the concept was preceded by the efforts of a group of scientists called the Club of Rome, whose work influenced the world community in understanding the dangers of the ecological crisis. Modern scientists consider the work of the Russian scientist V. I. Vernadsky on the biosphere and noosphere a worldview platform for sustainable development. The institutional mechanism for ensuring sustainable economic development is understood to mean a set of interrelated elements: institutions, methods, instruments that ensure the link between economic growth and intensive use of materials and energy consumption, and the formation of sustainable "green" economic growth. Energy efficiency, energy production and storage, transport, agriculture, construction, water supply, production and industry are the priority areas for investment in the transition to a "green" economy, according to the estimates of the United National Environment Program. The analysis of Russian practice allows us to state that at present environmental problems are not yet a priority for Russian companies. Partly, this is due to the lack of development of discussion in society and at the political level on environmental issues, to the lack of mastery of "green" technologies and many other reasons. The problem of developing and implementing "green" innovations remains at the level of government rhetoric, without concrete active actions. At the same time, the lack of a state policy in the field of "green" innovations is not the only problem. Private investment is equally important. It is necessary to expand the state presence in the market of "green" technologies, to develop state support for "green" innovative projects with high multiplicative potential, public-private partnership, international cooperation in this field.
Exosome-mediated immune regulation and its clinical application
Authors: Seo Naohiro
Published: March 2018

Immune system is a precise mechanism for maintenance of homeostasis by lymphocyte-mediated elimination of extracellular and intercellular pathogens, and abnormal cells in cytokine-, chemokine-, antibody-, and cytotoxic granule-dependent manners. Extracellular vesicles, e.g. exosomes, released from multivesicular endosome in immune cells have been known to be a part of the immune system. Exosomes released by antigen-presenting cells (APCs) such as macrophages and dendritic cells (DCs) regulate natural killer (NK) cells, CD8+ T cells (Cytotoxic T lymphocytes [CTLs]), and CD4+ T cells (Th cells) including Th1, Th2, and regulatory T (Treg) cells. In the anti-tumor immune system, NK cells and CTLs are mainly involved in the elimination of tumor cells by direct interaction. Recently, we clarified that tumor-infiltrating CD8+ T cells prevent tumor invasion and metastasis by exosome-mediated destruction of tumor stroma consist of mesenchymal stem cells (MSCs) and cancer-associated fibroblasts (CAFs). In this review article, we describe the role of exosomes in controlling immune system and its clinical application.
Obtaining First and Second Order Nomoto Models of a Fluvial Support Patrol using Identification Techniques
Authors: Carrillo Sandra , Contreras Juan
Published: March 2018

In this paper we present a method for obtaining a second order Nomoto model that describes the yaw dynamic of a Patrol River Boat. This model is obtained from experimental input and output data gathered from the turning circle maneuver. System identifications techniques and a gray box model are employed to find the coefficients of the Nomoto model.  The results of the identification process as well as the results of validation process are presented
Hydrodynamic study of the influence of bulbous bow design for an Offshore Patrol Vessel using Computational Fluid Dynamics
Authors: Leal Luis , Flores Edison , Fuentes David , Verma Bharat
Published: March 2018

The resistance of a ship is of vital importance in giving greater viability to the development of a design project, since at lower ship resistance, the power demand to achieve a desired design speed will be lower which will reduce the amount of power to be installed in the ship resulting in lower fuel consumption. The use of computational fluid dynamics to analyze and optimize hull form and its appendages permits the hydrodynamic performance of the ship to be improved from the early design stages, allowing improvements to the hull shape and appendages. This paper shows a qualitative analysis which was performed to reduce the resistance of the OPVMKII (Second Generation Offshore Patrol Vessel) in its preliminary design stage by means of designing and integrating three types of bulbous bow with the ship´s hull and analyzing the resistance curves obtained using computational fluid dynamics.
Development of Materials for Naval, Fluvial and Military Applications
Authors: Suarez- Bustamante Fabio A. , Barrios-Revollo Orlando D. , Valencia Anderson , Hernandez-Ortiz Juan P.
Published: March 2018

A platform to design composite materials of a polymeric matrix, that are specifically for military applications on fluvial and naval navigation, has been developed using energy dissipation and storage mechanisms. Our composites are designed to generate synergy between the dissipation capacities of ceramics and high-performance fibers, which are used as the reinforced material in the lightweight laminates. The composite design is combined with processing tools and advanced characterization techniques that result in laminates with reliability, traceability and quality. The platform begins with the identification of energy dissipation mechanisms and the detailed characterization of the polymeric resin. It includes the Time – Temperature – Transformation Diagram (TTT- Diagram) that supplies the optimal processing conditions. Our designs open new paths for military applications including a wide spectrum of protective systems together with geometric versatility, high mechanical resistance and reliability