bluuebunny/crossref_metadata_2025 huggingface dataset:
ICO vs. IPO – Prospektrechtliche Anforderungen bei Equity Token Offerings
Authors: Hahn Christopher , Wilkens Robert
Published: February 2019

Mit Initial Coin Offerings (ICOs) ist auf Basis der Blockchain-Technologie eine neuartige Form der Unternehmensfinanzierung entstanden, die das Potenzial hat, klassische VC-Investments in den Schatten zu stellen. Trotz der sprachlichen Ähnlichkeit haben ICOs meist wenig mit einem Börsengang (Initial Public Offering, IPO), zu tun. Mit den sog. Equity Token Offerings (ETOs) hat sich jedoch eine besondere ICO-Form herausgebildet, die zwar weniger in sprachlicher, dafür aber umso mehr in funktionaler Hinsicht mit einem klassischen IPO vergleichbar ist und nun auch in Deutschland in den Startlöchern steht. ETO-Initiatoren treibt dabei vor allem. die Frage nach einer möglichen IPO-ähnlichen Prospektpflicht um.
Empirische Evidenz zu Eigenschaften von Online- bzw. Mobile-Banking-Kunden in Deutschland
Authors: Becker Michel
Published: February 2019

Der Finanzdienstleistungssektor verändert sich durch Digitalisierung massiv. Online- bzw. Mobile Banking stellen mittlerweile wesentliche Plattformen in dessen Multi-Kanal-Vertrieb dar. Für das zeitgemäße Management dieser digitalen Kanäle sind fundierte Kenntnisse über ihre Nutzerstrukturen essenziell. Hierzu identifiziert und diskutiert der vorliegende Beitrag theoretische Modelle und insbesondere 26 empirische Studien, die Aussagen zu Eigenschaften von Online- bzw. Mobile-Banking-Kunden in Deutschland treffen. Diese werden studienübergreifend visualisiert und führen anschließend zu einer Charakterisierung der Kunden. Neben der Zusammenfassung der inhaltlichen Ergebnisse findet auch eine kritische Würdigung des methodischen Vorgehens der betrachteten Studien statt. Abschließend werden Lücken der bisherigen Literaturlandschaft dargelegt und relevante Fragestellungen für künftige Beiträge aufgezeigt.
Die EU-Taxonomie für nachhaltige Finanzprodukte – Eine belastbare Grundlage für Sustainable Finance in Europa?
Authors: Stumpp Maximilian
Published: February 2019

Die EU-Kommission hat am 24. 5. 2018 ein erstes Legislativpaket für Sustainable Finance vorgelegt. Neben der Schaffung diverser Transparenzpflichten, die nicht nur Anbieter nachhaltiger Finanzprodukte erfassen, ist darin die Einführung eines einheitlichen Klassifikationssystems für Nachhaltigkeit innerhalb der EU („Nachhaltigkeitstaxonomie“) vorgesehen. Die Taxonomie und ihre Auswirkungen werden in diesem Beitrag analysiert und vor dem Hintergrund der EU-Strategie für Sustainable Finance eingeordnet.
Monoclonal Antibody Treatment of RSV Bronchiolitis in Young Infants: A Randomized Trial
Authors: Alansari Khalid , Toaimah Fatihi Hassan , Almatar Daher Helmi , El Tatawy Lamiaa Awny , Davidson Bruce L. , Qusad Mohammad Ibrahim Mohammad
Published: February 2019

BACKGROUND:

Monoclonal antibody to respiratory syncytial virus (RSV; palivizumab) is recommend for prophylaxis of high-risk infants during bronchiolitis seasons but not for RSV bronchiolitis treatment. Our aim was to determine if palivizumab would be helpful in young infants with acute RSV bronchiolitis.

METHODS:

Eligible infants ≤3 months old presenting to the pediatric emergency service with RSV-positive bronchiolitis requiring inpatient admission underwent double-blind random assignment to single-dose intravenous palivizumab (15 mg/kg) or placebo. The primary efficacy outcome was the need for inpatient readmission in the 3 weeks after discharge. Secondary outcomes were time to readiness for hospital discharge, need for PICU on the initial admission, and need for revisit not requiring readmission for the same illness during 3-week follow-up.

RESULTS:

A total of 420 infants (median age 49 days) diagnosed with RSV bronchiolitis were randomly assigned; 417 received treatment, and 413 completed follow-up. Readmission during follow-up was needed for 23 (11%) patients on palivizumab and 19 (9.3%) patients in the placebo group (difference 1.8%; 95% confidence interval −4.4% to 7.7%; P = .51). Geometric mean time to readiness for discharge was 29.5 hours for the palivizumab group and 30.2 hours for the placebo group (ratio 0.98; 95% confidence interval 0.81 to 1.20). No safety issues were reported.

CONCLUSIONS:

Intravenous palivizumab did not appear to help or harm young infants with acute RSV-positive bronchiolitis.
Geographic distribution of Phalloceros Eigenmann, 1907 (Cyprinodontiformes, Poeciliidae) in the Ilha Grande Bay Hydrographic Region, Rio de Janeiro, Brazil
Authors: Souto-Santos Igor Cavalcanti de Araújo , Ferraro Gustavo Andrés , Jennings William Bryan , Vergara Gabriela Lucia da Silva , Buckup Paulo Andreas
Published: February 2019

The diversity and geographic distribution of Phalloceros Eigenmann, 1907 in the Ilha Grande Bay Hydrographic Region, in southeastern Brazil, is investigated. Examination of 81 samples revealed the presence of 5 species in the region: Phalloceros anisophallos Lucinda, 2008, P. aspilos Lucinda, 2008, P. enneaktinos Lucinda, 2008, P. harpagos Lucinda, 2008, and P. tupinamba Lucinda, 2008. Phalloceros harpagos and P. tupinamba are recorded for the first time in the area. The geographic ranges of P. anisophallos and P. enneaktinos are expanded. The 5 species belong to 3 distinct morphologies of the female urogenital papilla. Species from these distinct morphological lineages may occur sympatrically, but species within the same lineage are always allopatric. A key for the identification of these species is provided.
First record of the invasive Nile Tilapia, Oreochromis niloticus (Linnaeus, 1758) (Perciformes, Cichlidae), on Bawean Island, Indonesia
Authors: Hasan Veryl , Tamam Muhammad Badrut
Published: February 2019

In 2018 we captured specimens of Oreachromis niloticus (Linnaeus, 1758) from Danau Kastoba, a crater lake on Bawean (Indonesia), a small, isolated island in the Java Sea. Additional individuals were later photographed. These records are among first of this species from an isolated island, in the Java Sea. A description of meristic and morphometric features of a specimen are provided.
Current Status of Platinum Based Nanoparticles: Physicochemical Properties and Selected Applications – A Review
Authors: Sakthivel C. , Keerthana L. , Prabha I.
Published: February 2019

The present article reviews the synthesis routes and applications of platinum-based nanoparticles in emerging fields such as energy harvesting, health care applications and sensors. Increasingly, more useful, novel and multifunctional materials are needed with fewer side effects. This article provides an overview of Pt-based nanoparticles along with recent applications in electrochemistry, photochemistry, biosensors and gas sensors. In particular, platinum dioxide (Adams’ catalyst) has been used in many chemical reactions including hydrogenation, oxidation and reduction.
Development of a Transgenic Flammulina velutipes Oral Vaccine for Hepatitis B
Authors: Huang Li-Hsin , Lin Hao-Yeh , Lyu Ying-Tzu , Gung Chiau-Ling , Huang Ching-Tsan
Published: February 2019

Orally administered fungal vaccines show promise for the prevention of infectious diseases. Edible mushrooms are deemed appropriate hosts to produce oral vaccines due to their low production cost and low risk of gene contamination. However, their low expression level of antigens has limited the potential development of oral vaccines using mushrooms. The low expression level might result from impurity of the transgenic mycelia since dikaryotic mycelia are commonly used as transformation materials. In this study, stable transgenic hepatitis B virus surface antigen (HBsAg) in Flammulina velutipes transformants was obtained by Agrobacterium-mediated transformation, followed by fruiting and basidiospore mating. The formation of HBsAg was detected by western blot analysis. The expression levels of HBsAg in transgenic F. velutipes fruiting bodies were (129.3±15.1), (110.9±1.7) and (161.1±8.5) ng/g total soluble protein. However, the values may be underestimated due to incomplete protein extraction. Two of the four pigs in the experimental group produced positive anti-HBsAg-specific IgG after being fed the HBsAg transgenic F. velutipes fruiting bodies for 20 weeks, while no anti-HBsAg antibody was detected in the control group. One of the positive pigs had HBsAg titres of 5.36 and 14.9 mIU/mL in weeks 10 and 14, respectively, but expression faded thereafter. The other positive pig displayed HBsAg titres of 9.75, 17.86 and 39.87 mIU/mL in weeks 14, 18 and 20, respectively. The successful immunogenicity in pigs fed transgenic F. velutipes fruiting bodies demonstrated the potential of using the fungus as an oral vaccine.
In Vitro Assessment of the Antioxidant Properties of Aqueous Byproduct Extracts of Vitis vinifera
Authors: Puglisi Roberto , Severgnini Alex , Tava Aldo , Montedoro Marina
Published: February 2019

Aqueous extracts were obtained at low temperature with
the Naviglio technology from grapevine stalks (Merlot), marc (Merlot and
Cabernet Sauvignon) and leaves (Merlot) as typical byproducts of winemaking
industry, and their properties were evaluated cytofluorometrically on human
dermal fibroblasts. Leaf extracts had the greatest total phenolic ((47.6±3.5)
mg/g) and proanthocyanidin ((24.2±0.1) mg/g) contents compared to the others.
The preliminary colorimetric MTT
(3-[4,5-dimethylthiazole-2-yl]-2,5-diphenyltetrazolium bromide) assay
individuated two consecutive non-toxic volume fractions of each extract (from
0.8 to 12.8 %) that were adopted for three cytofluorometric tests. The first
cell membrane test did not evidence any harmful effects against plasma
membranes at the two non-toxic volume fractions. The second mitochondrial
membrane test showed a decreased (p<0.01) percentage of cells ((15.7±8.3) vs
(32.5±1.3) %) with active polarized mitochondrial membranes at the higher
non-cytotoxic volume fractions of extracts from Cabernet Sauvignon marc in
response to 4.5 mM H2O2, and from Merlot stalks
(p<0.05) at 1.5 mM H2O2 ((49.3±6.1) vs
(64.6±2.4) %) and without H2O2 ((89.7±2.4) vs
(96.9±1.8) %), compared to the controls submitted to the same H2O2
concentration. Conversely, mitochondrial activity of leaf extracts
significantly (p<0.05) increased ((96.3±1.8) and (96.4±1.4) %) after
treatment with 0.5 mM H2O2 at both non-cytotoxic
volume fractions compared to control ((88.2±1.1) %). Finally, as evidenced by
the third oxidative status test, stalk extracts did not evidence relevant
effects on the cellular oxidative state, while the extracts of marc and leaves
demonstrated significantly medium (p<0.05) to highly (p<0.001) positive
effects following exposure to H2O2 ranging from 0.5 to
4.5 mM, compared to controls.
Study of the Durban Bight shoreline evolution under schematised climate change and sand‑bypassing scenarios
Authors: Rautenbach C , Theron A
Published: February 2019

The Durban Bight beaches, on the KwaZulu-Natal coast of South Africa, have been the topic of several studies in the past, because of their recreational and economic value. These beaches are mainly nourished via a sand-pumping scheme, which has been the case since the 1980s. The present study investigated the longer-term dynamic stability of the Durban Bight beaches using a one-dimensional numerical shoreline model. The wave conditions that drive the longshore transport of sand were simulated using the numerical spectral wave model Simulation WAves in the Nearshore (SWAN). The shoreline model was calibrated and validated against existing historical data. The calibrated model was then employed to simulate possible future scenarios. These included climate change phenomena and the influence of anthropogenic changes. Each of the simulations predicts a twenty-year period, with results extracted at five-year intervals. The results are presented and discussed, and the emphasis is placed on the importance of maintaining the required sand-bypassing rates and the awareness of the possible effects of climate change on shoreline maintenance and management.
Cell dissociation from nasal and bronchial brushings withcold-active protease for single-cell RNA-seq v2
Authors: Zaragosi Laure-Emmanuelle , Barbry Pascal
Published: February 2019

This protocol provides details on the cell dissociation that should be performed to obtain single-cell suspensions from nasal epithelium brushings. Cell dissociation is performed at 4°C to avoid gene expression alterations and maximize viability. The typical cell number recovery is 200 000 - 300 000 for one brushing. Cell suspensions are suitable for single-cell RNA-sequencing protocols.
Tranfection of sgRNA using SpCas9 containing plasmids to generate cell lines with Cas9 v3
Authors: Kaur Binnypreet , Faktorová Drahomíra , Julius Lukeš not provided , not provided not provided , not provided not provided
Published: February 2019

This protocol describes transfection of ribonucleoprotein (RNP) complexes that consist of purified Cas9 nuclease duplexed with synthetic guide RNA in cultured cells using the AMAXA Nucleo AMAXA Nucleofector II Electroporation system using Program X-001. RNPs complex have only transient expression inside the cell, this allows for the highest levels of editing efficiency and greatly reduces the chances of possible off target and toxic effects of integration of foreignDNA in host genome
Freezing Tissue in OCT using Isopentane v1
Authors: Tuck Liz
Published: February 2019

Introduction This protocol describes how to freeze tissues in OCT using dry-ice cooled isopentane (for downstream cryo-sectioning). Related Documents Risk assessment: WTSI-3200_ Freezing Tissue using Isopentane
Wave Statistics for the Middle Adriatic Sea
Authors: Farkas Andrea , Parunov Joško , Katalinić Marko
Published: February 2019

The paper presents the methodology and results of the sea state statistics development for the middle Adriatic Sea. The study is based on the World Waves Atlas containing data of sea states in the Adriatic Sea calibrated using different satellite missions and numerical wave model simulations during the period of past 23 years. Wave scatter diagram and wave rose at the location in the middle Adriatic Sea are derived from the data. The 3-parametric Weibull distribution and the log-normal distribution for significant wave height and peak spectral periods respectively, are fitted through the data in the World Waves Atlas. Based on available data, the relation between wind speed and wave height is established by regression analysis. Comparison of the relationship between the significant wave height and peak spectral period is performed between the data from the World Waves Atlas and the Tabain’s wave spectrum, frequently used for sea states in the Adriatic Sea. Finally, the most probable extreme sea states for different return periods are calculated and results are compared with another relevant study for the long-term prediction of sea states in the Adriatic Sea.
Bridge officers’ operational experiences with electronic chart display and information systems on ships
Authors: Bakalar Goran , Baggini Myriam Beatriz
Published: February 2019

In this paper, authors suggest an improvement in the electronic chart display and information system handling. Electronic nautical charts provide significant benefits to maritime navigation as a real time navigation system and all updates are important. This paper analyses the electronic chart use experiences on board ships. A questionnaire and survey were used so as to ascertain and corroborate the existing problems with corrections and maintenance of electronic charts on ships, and reliability of the systems was calculated. The survey results have shown that ship’s officers had serious problems with ECDIS systems which were difficult to solve during ship’s operation. A survey was done which showed that a significant percentage of the surveyed bridge officers and captains had problems with ECDIS system operation, such as operation stoppage due to different reasons. They did not always report failures of these systems while having continued to operate ECDIS. The reliability of those systems was also calculated and it resulted 0.916 or 91.6%. Compared to results of previous similar researches done by other scientists, the results of this research show an improvement in the ECDIS handling. It was concluded that a proper action was needed toward finding the solution to the future chart corrections procedure through remote monitoring and maintenance. The study results emphasized that taking action was necessary in the interest of safety protection on ships, with particular attention to be paid to better safety of navigation, of life, and of potential environmental pollution due to this type of information system failures. The results obtained by this study represent a good starting point for future researches in the field.
A comparative study of efficacy and safety of topical calcitriol and topical calcipotriol in stable chronic plaque type psoriasis
Authors: Hugar Leela , H. Ramesh
Published: February 2019

Background: Topical calcitriol and calcipotriol, the two vitamin D derivatives although considered efficient in treating psoriasis, their comparative studies are relatively scanty. The objective of the present study was to evaluate and compare the efficacy and safety of calcitriol and calcipotriol in stable chronic plaque-type psoriasis.Methods: Total 50 patients of chronic stable plaque-type psoriasis were randomly divided into two groups of 25 each. One group received calcitriol 3µg/g ointment and the other group received calcipotriol 50µg/g ointment twice daily for 12 weeks. Efficacy evaluations comprised global improvement (on a 4-point scale from 0: no change, to 3: clear or almost clear) assessed clinically and by the subject. Efficacy further included the ‘dermatological sum score’ (DSS) at each study visit. Safety evaluations (on a 5-point scale from 0: none, to 4: very severe) included clinical assessment of cutaneous safety and assessment of cutaneous discomfort by the subject.Results: Both calcitriol and calcipotriol were significantly effective (p <0.001) in reduction of DSS but the difference between the two groups was not statistically significant. Mean score of global improvement assessed clinically was 2.20 for calcitriol and 2.16 for calcipotriol (p >0.05) and by the subject was 1.92 for calcitriol and 1.84 for calcipotriol (p >0.05). The difference between the two groups was not statistically significant. The mean worst score for cutaneous safety was higher in calcipotriol group compared to calcitriol group (0.28 vs 0.04 and 0.36 vs 0.04 by clinically and by the subject, respectively). Statistically significant better safety profile (p <0.05) was seen for calcitriol, only when assessed by the subject. 24% treatment related adverse events were reported with calcipotriol against only 4% with calcitriol.Conclusions: Topical calcitriol and calcipotriol showed similar efficacy in the treatment of chronic plaque psoriasis while calcitriol showed better safety profile in comparison with calcipotriol, in terms of local tolerance and induced less treatment related adverse events.
Calcaneal fractures: a management dilemma-minimally invasive approach for intra and extra articular calcaneal fractures
Authors: M. S. Kawade , H. S. Madan , Khachane Shailesh , Dhanda Manjeet Singh
Published: February 2019

Background: Calcaneal fractures which constitutes 2% of total fractures are frequent and very debilitating if not treated properly. Calcaneal fractures generally affect younger population leading to significant man-days loss(around 2-5 years3) and in-turn leading significant economic burden on the society. The goal of treatment for calcaneal fractures is elimination of pain and restoration of normal foot shape, biomechanics, and walking ability. Wound related complications are common with open surgeries. After open reduction internal fixation with perimeter plates for displaced calcaneal fractures, wound edge necrosis is commonly observed with the extended lateral approach. Because of such high incidence of wound complications in open reduction of calcaneum fractures, minimally invasive approach takes priority over open reduction of these fractures.Methods: The study aimed to evaluate the results of minimally invasive approach for calcaneal fractures. To reduce the operative complications, 30 patients were treated with minimally invasive methods in both extra articular and intra-articular calcaneal fractures and the results were evaluated. All patients were evaluated clinically , functionally and radiologically 3D- CT reconstruction images.Results: All cases were followed up for 2 years at specified intervals. The outcome measures were evaluated by AOFAS scores10 with excellent result in 13 cases and good to fair results in the rest. Operated patients had no wound infection, no skin necrosis, 5 patients had mild subtalar arthrosis and 3 patients complained slight difficulty in wearing shoes. None of them have any gait abnormalities.Conclusions: Our study suggests that the minimally invasive methods will reduce the operative complication rates. The minimally invasive surgical intervention in an expert hand can yield better results with less complication rates.
Management of sleeve gastrectomy leakage with endoscopic stenting
Authors: Dogan Fadli , Dincer Mürsit
Published: February 2019

Background: Sleeve gastrectomy is one of the most commonly applied procedures for obesity surgery. Leakage from the stapler line and bleeding are the most important complications of sleeve gastrectomy. This study aimed to report the results of esophageal stent procedure applied to cases who developed leaks after sleeve gastrectomy.Methods: This study included patients who had sleeve gastrectomy due to morbid obesity and were detected to have a leak after the procedure. Demographic features, time of leakage after the surgery, and the management of the leak were analyzed.Results: it was detected in this study, 1220 cases who had sleeve gastrectomy for morbid obesity. Leaks were developed in 10 patients after Laparoscopic Sleeve Gastrectomy (LSG). Four patients, followed conservatively without stent application, were excluded. Six patients, treated with stent application, were included. Two of the patients were males, and four were females (M/F=1/2). The mean age was 38.3 (±11.57) (range: 26-58). The mean body mass index was 43.26 (±2.10)kg/m2. The incidence of a leak was 0.81%.Conclusions: In a conclusion, stents can be safely applied by experienced endoscopists for the management of sleeve gastrectomy leakage.
Retrospective and prospective analysis of clinical, radiological and prognostic factors affecting surgical denouement in ossified posterior longitudinal ligament: an institutional experience
Authors: Raykar Rajesh R. , Bettaswamy Guruprasad , Singh Rajesh Kumar , M. Mahendra
Published: February 2019

Background: The most common cause of radiculopathy or myelopathy is “ossification of the posterior longitudinal ligament (OPLL)”. Surgical management consists of various anterior and posterior procedures. Anterior procedures done are corpectomy and fusion. Posterior procedures include laminectomy and laminectomy with fusion that include the use of lateral mass or pedicle screws with rods. Objective was to study the clinical course and to delineate clinico-radiological prognostic factors with regard to surgical outcome.Methods: Patients operated for cervical OPLL were included. Detailed clinical history and radiological findings were retrospectively taken from the case records of the patients and prospectively recorded in the cases operated till May 2018. A minimum follow-up of 6 months was done for improvement. Preoperative clinical evaluation was done. Surgical options were individualized for each patient. Detailed clinical evaluation was done at discharge and at follow-up.Results: It has been found that those patients who were admitted with Nurick’s myelopathy grade IV and V at admission, those with higher number of levels involved like 5, 6 and 7, those with duration of symptoms of more than one year were more likely to have same or deteriorated outcome compared to their counterparts. Other parameters were not found to be significantly associated with outcome.Conclusions: Duration of symptoms >12 months, Sphincter disturbances were significant poor clinical prognostic markers. Significant poor radiological prognostic markers were segmental stenotic index <0.4, MRI T2-Weighted hyper intense signal change.
Improved sensitivity of direct microscopy for Mycobacterium tuberculosis in lymph nodes: comparison of fluorescent microscopy and modified bleach method ZN microscopy along with conventional ZN staining method
Authors: Aalmeen Gul , Sharma Sangeeta , Vishwasrao Sneha , Bansal Rani , Khare Anjali
Published: February 2019

Background: Extra pulmonary tuberculosis arises as a result of lymphatic spread from a primary focus. Fine needle aspiration cytology has assumed an important role in the evaluation of peripheral lymphadenopathy as a possible minimally invasive alternative to excisional biopsy. In most low-income countries; the only practically available bacteriologic method for diagnosing EPTB is direct smear microscopy for acid fast bacilli from the sample of the lesion. There are various methods of staining and concentration for improving sensitivity of direct microscopy for detection of tubercle bacilli in specimen.Methods: This prospective study was carried out in the Department of Pathology, Subharti Medical College and associated Chattrapati Shivaji Subharti Hospital, Meerut for a period of 2 years from July 2016 - August 2018 in 151 patients with clinical suspicion of TB and significant lymphadenopathy.Results: AFB positivity increased from 40.39% on conventional ZN stain to 48.34% on modified bleach method ZN stain and to 56.29% on Auramine-O fluorescent stain. Taking fluorescent microscopy (Auramine-O) as reference method the sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy of conventional ZN stain and modified bleach method ZN stain were calculated as 71.8%, 100%, 100%, 73.33%, 84.10% and 85.33%,100%,100% ,84.61% ,92.05%, respectively.Conclusions: The addition of fluorescent microscopy (Auramine-O) and modified bleach method ZN microscopy along with conventional ZN staining method would be an important adjunct to improve the microscopic detection of Mycobacterium tuberculosis in ﬁne-needle aspirates of lymph nodes.
Study of surgical fixation of extra-articular distal third humerus fractures with a posterolateral locking compression plate
Authors: Kumar Ravi , Karwasra Ajay , Kunal Kishore
Published: February 2019

Background: Fractures of the adult distal humerus account for approximately 2% of all fractures and represent a third of all humerus  fractures. Fractures of the distal third of the humerus are challenging injuries due to their peri-articular location, small size of the distal bone fragments, and the osteopenic quality of the bone in older adults.  Aim of our study was to evaluate the clinical, radiographic and functional outcomes of posterolateral locking compression plate for extra-articular distal third humerus fractures through posterior triceps splitting approach.

Methods: This is a prospective study done at All India Institute of Medical Sciences, Patna  in which 30 consecutive skeletally mature, closed extra-articular distal humerus fractures  underwent fixation with posterolateral  locking compression plate and outcome evaluated in terms of radiological  evidence of healing, functional outcome and complications if any.

Results: Use of posterolateral plate results in predictably good union rates and excellent results terms of patient outcome without any implant related complications.

Conclusions: We recommend using this posterolateral plate for these humerus fractures, because of its consistent results with respect to fracture union, stability across the fracture site and early mobilization for better functional results.
TIPE DAN GAYA KEPEMIMPINAN PENDIDIKAN DAN DAKWAH
Authors: Akbar Nadzmi
Published: February 2019

Leadership style adopted by a leader in educational institutions, will mentukan atmosphere and climate in the next educational institutions also determine the effectiveness of health efforts in the purpose of education. Leadership is born with a process, not innate from birth to be able and trained to achieve the competence of leadership that berkulaitas, so that in the institutional education can achieve optimal effectiveness. The style of leadership is the way used in the leadership process that is implemented in a person's task to face each other for what he wants. There are two styles of leadership that is style of leadership style, leadership style, leadership style. Dakwaha leadership style is a leader who is able to bring society to success in the pleasure of Allah SWT. In this case the leader will always appear to achieve the benefit and welfare of his followers for the salvation of the life of the world and the hereafter. Thus the style seoarang da'wah leaders and education will not be separated from three things as a mentor, as a model and as a practitioner. Dakwah leadership style is a model and style of leadership with its own formulation.
FILOSOFIS KOMUNIKASI QAULAN SYAKILA
Authors: Fahriansyah Fahriansyah
Published: February 2019

The principles of comunication in the Qur’an are interesting to examine, even the comunications thinkers have found there are six principles of comunication in al qur’an such as qawlan sadidan, qawlan balighan, qawlan maysura, qawlan layyinan, qawlan kariman and qawlan ma’rufan, but the opinion can be added again one principle that is qawlan tsaqila principle that is a weighted communication, then what and how qawlan tsaqila ?, this paper will explain briefly iti is in addition to the six principles of comunication in al Qur’an put forward by the communications leaders muslim Indonesia.
STRATEGI PROMOSI WISATA RELIGI MAKAM SYEKH SURGI MUFTI
Authors: Noviyanti Devi
Published: February 2019

Indonesia is a pluralistic country. This plurality produces Indonesia rich in various aspects, such as ethnicity, language, culture and religion so that it supports the fields for sustainable development. South Kalimantan, which is one of the provinces in Indonesia, has a great potential to be developed into an attractive business opportunity because of the number of tourist objects that can be visited by tourists, both domestic and foreign. South Kalimantan offers typical local cultural characters such as the typical Banjar traditional house, Agung Amuntai Temple, Floating Market, typical Banjar fabric craftsmen village, Sasirangan and others. In addition to offering natural and cultural attractions. South Kalimantan is also famous for its religious tourism where one is expected to be the tomb of the famous Ulama which is visited by pilgrims, namely the dome of Surgi Mufti KH. Jamaluddin who also came from a great ulama from South Kalimantan, Sheikh Muhammad Arsyad Al-Banjari. The Surgi Mufti Dome is also one of the pilgrimage attractions designated as cultural heritage sites approved by the Republic of Indonesia Law Number 11 of 2010. The Dome of the Surgi Mufti is located on Jalan Mesjid Jami, Surgi Mufti Village, North Banjarmasin District, Banjarmasin City. In order to develop tourism objects in the South Kalimantan region, one of them is the Tomb of Sheikh Surgi Mufti, so tourism promotion or communication efforts are needed as a strategy that can provide information on tourist destinations in detail and clearly
Penerapan Konsep Utilitarianisme Untuk Mewujudkan Perlindungan Konsumen Yang Berkeadilan Kajian Peraturan Otoritas Jasa Keuangan Nomor: 1/POJK.07/2013 Tentang Perlindungan Konsumen Sektor Jasa Keuangan
Authors: Wibowo Dwi Edi
Published: February 2019

Abstrak Peranan internet dalam teknologi informasi telah digunakan untuk mengembangkan industri keuangan  (financial industry)  melalui modifikasi dan efisiensi layanan jasa keuangan yaitu dikenal dengan istilah Financial Technology atau Fintech. Fintech jenis pinjam-miminjam uang berbasis teknologi atau peer to peer lending (P2P-lending) merupakan jenis Fintech yang tumbuh pesat di Indonesia, kelebihan pinjam meminjam uang melalui layanan P2P-lending lainnya adalah syarat yang sangat mudah dan proses yang cepat dibandingkan meminjam uang melalui Lembaga Bank. Namun kemudahan transaksi yang ditawarkan oleh layanan P2P- lending justru memperlemah posisi dari konsumen. Permasalahan Bagaimanakah Penerapan Konsep Utilitarianisme Untuk Mewujudkan Perlindungan Konsumen Fintech. (Financial Technology) Yang Berkeadilan, Tujuan  untuk mengetahui bagaimanakah penerapan konsep utilitarianisme untuk mewujudkan perlindungan kosnumen fintech ( finansial technology yang berkeadilan . Kata kunci : utilitarianisme, perlindungan konsumen, berkeadilan Abstrak The role of the internet in information technology has been used to develop the financial industry through the modification and efficiency of financial services, known as Financial Technology or Fintech. Fintech borrows money based on technology or peer to peer lending (P2P-lending) is a fast-growing type of Fintech in Indonesia, the advantages of lending and borrowing via other P2P-lending services are very easy conditions and a fast process compared to borrowing money through Bank Institution. But the ease of transactions offered by P2P-lending services actually weakens the position of consumers. Problems How to Implement the Utilitarianism Concept to Realize Fintech Consumer Protection. (Financial Technology) that is just, the aim is to find out how the application of the concept of utilitarianism is to realize the protection of fintech consumers (equitable technology finance. Keywords: utilitarianism, consumer protection, justice
Estrategias de aprendizaje autónomo en la comprensión lectora de estudiantes de secundaria
Authors: Medina Coronado Daniela , Nagamine Miyashiro Mercedes María
Published: February 2019

Al observar en las aulas de clase del nivel secundaria, así como del nivel superior la forma como los adolescentes y jóvenes estudian, surgió la idea de conocer si cuentan con estrategias para el aprendizaje independiente y de si esta variable explicaba en alguna medida un problema crítico en el Perú: la comprensión lectora. Es por ello, que se planteó como propósito del estudio, conocer si las estrategias de aprendizaje autónomo, sus dimensiones e indicadores tienen algún poder explicativo sobre la comprensión lectora. Bajo un diseño correlacional causal de carácter exploratorio, se aplicaron los siguientes instrumentos: Cuestionario de estrategias de trabajo autónomo (CETA) que evalúa las estrategias de ampliación, colaboración, conceptualización, planificación, preparación de exámenes y participación y prueba PECL 2 para medir niveles de comprensión de la lectura: literal, inferencial y criterial en un grupo de 144 estudiantes de IE de los distritos de Majes en Arequipa y Villa Rica en Pasco. Entre los resultados más importantes se obtuvo que el 79.33% de estudiantes alcanzaron un nivel en proceso en cuanto al uso de estrategias de aprendizaje autónomo y el 62.7% alcanzó el mismo nivel en la comprensión lectora; así mismo, se halló que el 34.4% de la variable comprensión lectora es explicada por el uso de estrategias de aprendizaje autónomo, de ese total, un 25.8% por las estrategias de ampliación, 14.3% por las estrategias de colaboración, 28.7% por las estrategias de conceptualización, 19.6% por las estrategias de preparación de exámenes y finalmente un 19.5% por las estrategias de participación.

 
Predominancia del autoconcepto en estudiantes con conductas antisociales del Callao
Authors: Palacios-Garay Jessica , Coveñas-Lalupú José
Published: February 2019

El  objetivo  de la investigación  fue  determinar la dimensión  predominante que más influye en el autoconcepto en estudiantes con conductas antisociales. El trabajo en mención es de tipo sustantiva, de un diseño  no experimental de corte transversal. El método empleado fue el hipotético deductivo. La muestra estuvo conformada por 98 adolescentes con conductas antisociales, el muestreo utilizado fue el no probabilístico intencional. El instrumento  utilizado  fue AF-5 de García y Musitu (1999). Los resultados indicaron que el autoconcepto que influye en las adolescentes, fue el autoconcepto emocional
THE CLINICAL SIGNIFICANCE OF THE DAILY MONITORING OF HOLTER ECG IN CHRONIC GLOMERULONEPHRITIS AT THE PREDIALYSIS STAGE OF THE DISEASE
Authors: Murkamilov I. T. , Sabirov I. S. , Fomin V. V. , Murkamilova Zh. A. , Sabirova A. I. , Aitbaev K. A. , Imanov B. Zh. , Redzhapova N. A. , Yusupov F. A.
Published: February 2019

This article presents the results of our own research: comprehensive clinical and laboratory examinations, including data from the daily Holter monitoring of the electrocardiogram (DMEKG) in 169 patients with chronic glomerulonephritis at the predialysis stage of the disease. According to the DMEKG, 60.3% of the persons examined by us had episodes of supraventricular group extrasystoles, and ventricular group extrasystoles in 28.9%. In addition, 11.2% of patients had atrial ventricular blockade (incomplete / partial), 8.8% had atrial fibrillation and painless ischemia in an amount of from 1 to 3 episodes per day in 14.7%. Depending on the average heart rate (HR) according to the DMEKG, patients with chronic glomerulonephritis were divided into two subgroups. Subgroup “A” included 38 patients with heart rate less than or equal to 70 beats / min, in subgroup “B” — 131 patients with a heart rate of more than 70 beats / min. With equal values of uric acid, total cholesterol cholesterol, HDL cholesterolcholesterol, TG, plasma creatinine and blood fibrinogen in subgroup “B” there was a statistically significant increase in LDL cholesterol concentration(3.58 (2.74; 5.54) mmol / l vs. 2, 82 (2.30; 3.86) mmol / l; p <0.05) and a decrease in the calculated GFR (70.4 (48.8; 96.3) ml / min vs. 85.7 (31.5; 103,1) ml / min; p <0.05) compared with subgroup “A”. In the subgroup “B” a tendency was observed to increase the degree of daily excretion of protein with urine. The data obtained confirm the fact that the conduct of the DMEKG with the analysis of heart rate is of significant clinical importance for the diagnosis of cardiovascular disorders and the p revention of cardiovascular complications in chronic glomerulonephritis at the predialysis stage of the disease.
CARDIORENAL SYNDROME IN PATIENTS WITH CHRONIC HEART FAILURE AS A STAGE OF THE CARDIORENAL CONTINUUM (PART I): DEFINITION, CLASSIFICATION, PATHOGENESIS, DIAGNOSIS, EPIDEMIOLOGY
Authors: Reznik E. V. , Nikitin I. G.
Published: February 2019

The combination of heart failure and renal failure is called cardiorenal syndrome. It is a stage of the cardiorenal continuum and, possibly, a small link of the cardiorenal-cerebral-metabolic axis. Despite the fact that the phrase “cardiorenal syndrome” and its five types have become a part of the medical lexicon, many aspects of this problem are still not clear. Cardiorenal syndrome can be diagnosed in 32-90.3% of patients with heart failure. Cardiorenal syndrome type 1 or 2 develops in most cases of heart failure: cardiorenal syndrome presents with the development ofchronic kidney disease in patients with chronic heart failure and acute kidney injury in patients with acute heart failure. Impaired renal function has an unfavorable prognostic value. It leads to an increase in the mortality of patients with heart failure. It is necessary to timely diagnose the presence of cardiorenal syndrome and take into account its presence when managing patients with heart failure. Further researches are needed on ways toprevent the development and prevent the progression of kidney damage in patients with heart failure, to which the efforts of the multidisciplinary team should be directed. The first part of this review examines the currently definition, classification, pathogenesis, epidemiology and prognosis of cardiorenal syndrome in patients with heart failure.
Cell-Based Fish: A Novel Approach to Seafood Production and an Opportunity for Cellular Agriculture
Authors: Rubio Natalie , Datar Isha , Stachura David , Krueger Kate
Published: February 2019

Cellular agriculture is defined as the production of agricultural products from cell cultures rather than from whole plants or animals. With growing interest in cellular agriculture as a means to address the public health, environmental, and animal welfare challenges of animal agriculture, the concept of producing seafood from fish cell- and tissue-cultures is emerging as a means to address similar challenges with industrial aquaculture systems and marine capture. Cell-based seafood - as opposed to animal-based seafood - can combine developments in biomedical engineering with modern aquaculture techniques. Biomedical engineering developments such as closed-system bioreactor production of land animal cells create a basis for large scale production of marine animal cells. Aquaculture techniques such as genetic modification and closed system aquaculture have achieved marked gains in production that can pave the way for innovations in cell-based seafood production. Here, we present the current state of innovation relevant to the development of cell-based seafood across multiple species as well as specific opportunities and challenges that exist for advancing this science. The authors find that the physiological properties of fish cell- and tissue- culture may be uniquely suited to cultivation in vitro. These physiological properties, including hypoxia tolerance, high buffering capacity, and low-temperature growth conditions, make marine cell culture an attractive opportunity for scale production of cell-based seafood; perhaps even more so than mammalian and avian cell cultures for cell-based meats. This, coupled with the unique capabilities of crustacean tissue-friendly scaffolding such as chitosan, a common seafood waste product and mushroom derivative, presents great promise for cell-based seafood production via bioreactor cultivation. To become fully realized, cell-based seafood research will require more understanding of fish muscle culture and cultivation; more investigation into serum-free media formulations optimized for fish cell culture; and bioreactor designs tuned to the needs of fish cells for large scale production.
Specificity of Escherichia coli Heat-Labile Enterotoxin Investigated by Single-Site Mutagenesis and Crystallography
Authors: Heggelund Julie E. , Heim Joel B. , Bajc Gregor , Hodnik Vesna , Anderluh Gregor , Krengel Ute
Published: February 2019

Diarrhoea caused by enterotoxigenic Escherichia coli is one of the leading causes of mortality in children under five years of age and is a great burden on developing countries. The major virulence factor of the bacterium is the heat-labile enterotoxin (LT), a close homologue of the cholera toxin. The toxins bind to carbohydrate receptors in the gastrointestinal tract, leading to toxin uptake and, ultimately, to severe diarrhoea. Previously, LT from human- and porcine-infecting ETEC (hLT and pLT, respectively) were shown to have different carbohydrate-binding specificities, in particular with respect to N-acetyllactosamine-terminating glycosphingolipids. Here, we probed eleven single-residue variants of the heat-labile enterotoxin with surface plasmon resonance spectroscopy and compared the data to the parent toxins. In addition we present a 1.45 Å crystal structure of pLTB in complex with branched Lacto-N-neohexaose (Galbeta4GlcNAcbeta6[Galbeta4GlcNAcbeta3]Galbeta4Glc). The largest difference in binding specificity is caused by mutation of residue 94, which links the primary and secondary binding sites of the toxins. Residue 95 (and to a smaller extent also residues 7 and 18) also contribute, whereas residue 4 shows no effect on monovalent binding of the ligand and may rather be important for multivalent binding and avidity.
Sustainability in Alternative Food Networks: A Systematic Literature Review
Authors: Michel-Villarreal Rosario , Hingley Martin , Canavari Maurizio , Bregoli Ilenia
Published: February 2019

In recent years, increasing attention has been paid to individuals organizing themselves and managing food systems in an ‘alternative’ and more sustainable way. Such emerging food initiatives are most commonly known as ‘Alternative Food Networks’ (AFNs). However, there is an ongoing debate concerning the extent to which AFNs facilitate social, economic and environmental change. There are criticisms of the overall sustainability promise of AFNs related to sufficiency of impact, possible counter effects and relevance of impacts. Because often empirical studies only focus on specific sustainability issues or AFNs, it has been difficult to develop more robust theories about the relations between diverse AFNs arrangements and sustainability. Thus, the aim of this paper is to contribute towards reducing this knowledge gap through a systematic literature review on AFNs in relation to sustainability. We summarize main methodological approaches, types of AFNs studied and sustainability dimensions addressed in literature to date. Findings serve as reference to propose opportunities for future research regarding sustainability in AFNs.
Threshold Bloodstain Recognition Method Based on Hyper-spectral Imaging Technology
Authors: Hu Nannan , Wang Yunuan , Li Xiaofei , Liu Yonglei , Wang Jingjing , Zhang Liren , Zhao Yuefeng
Published: February 2019

The identification of bloodstain is one of the most important approaches in obtaining evidence in criminalistics. A threshold method based on spectral co-efficient and interclass variance is proposed in this paper, it is a non-contact, non-destructive method for quickly identifying bloodstains. The spectra of bloodstains and other suspected substances were all extracted from their hyper-spectral image. Then calculate the correlation coefficients of these spectral and interclass variances, analyze the differences between substances. The best blood recognition threshold was determined as 0.9. After preprocessing for eliminating systematic errors, experiments with the threshold 0.9 are carried out to identify bloodstains on the calico and red T-shirt. The method can remarkably identify the bloodstain from other non-blood substances both quickly and efficiently. The blood extraction rate can reach to 93.35% and 89.19%, respectively. It is an important step toward the implementation of bloodstain non-contact and non-destructive identification in forensic casework.
Rapid Monitoring of Organochlorine Pesticides Residues in Various Fruit Juices and Water Samples Using Fabric Phase Sorptive Extraction and Gas Chromatography-Mass Spectrometry
Authors: Kaur Ramandeep , Kaur Ripneel , Rani Susheela , Malik Ashok Kumar , Kabir Abuzar , Furton Kenneth G. , Samanidou Victoria
Published: February 2019

Fabric phase sorptive extraction, an innovative integration of solid phase extraction and solid phase microextraction principles, has been combined with gas chromatography-mass spectrometry for the rapid extraction and determination of nineteen organochlorine pesticides in various fruit juices and water samples. FPSE consolidates the advanced features of sol-gel derived extraction sorbents with the rich surface chemistry of cellulose fabric substrate, which could directly extract target analytes from complex sample matrices and substantially simplifies the sample preparation operation. Important FPSE parameters including sorbent chemistry, extraction time, stirring speed, type and volume of back-extraction solvent and back-extraction time have been optimized. Calibration curves were obtained in the concentration range 0.1-500 ng/mL. Under the optimum conditions, the limits of detection were obtained in the range 0.007-0.032 ng/mL with satisfactory precision (RSD<6%). The relative recoveries obtained by spiking organochlorine pesticides in water and selected juice samples were in the range of 91.56–99.83%. The sorbent sol-gel poly(ethylene glycol)-poly(propylene glycol)-poly(ethylene glycol) was applied for the extraction and preconcentration of organochlorine pesticides in aqueous and fruit juice samples prior to analysis with gas chromatography-mass spectrometry. The results demonstrated that the present method is simple, rapid, and precise for the determination of organochlorine pesticides in aqueous samples.