bluuebunny/crossref_metadata_2025 huggingface dataset:
Three-level hierarchical micro/nanostructures on biopolymers by injection moulding using low-cost polymeric inlays
Authors: Sáez-Comet Carlos , Muntada Olga , Lozano Nekane , Fontdecaba Enric , Sousa Patricia , Llobet Jordi , Perez-Murano Francesc , Puiggali Jordi , del Valle Luis Javier
Published: December 2022

The industrial interest in the patterning of polymeric surfaces at the micro/nanoscale to include new functionalities has considerably increased during the last years. Hierarchical organization of micro/nanometric surface textures yields enhanced functional properties such as hydrophobicity, hydrophilicity, antibacterial activity, and optical or chromatic effects to cite some. While high accuracy methods to pattern hierarchical surfaces at the nanoscale have been developed, only some of them have been applied for high volume manufacturing with limited success, mainly because they rely on the use of expensive machinery and moulds or complicated inserts. Therefore, a method using low cost recyclable tooling and process conditions applicable to high-volume manufacturing is currently missing. In this work, a scalable and low-cost method to replicate hierarchical micro/nanostructured surfaces on plastic films is presented, which can be latter used as inlays for injection moulded parts with standard processing conditions. This method is used to demonstrate the feasibility of replicating three level hierarchical micro/nano textured surfaces using recyclable bio-based polymers (of high relevancy in the current plastic pollution context) achieving replication ratios above 90%, comparing the replication results with those obtained in polypropylene. The presence of the micro/nanotextures substantially increases the contact angle of all the polymers tested, yielding values higher than 90° in all the cases. Also, various mechanical properties of the replicated parts for all the polymers injected are characterized one and thirty days after the samples were manufactured, showing fairly constant values. This highlights the validity of the replicated surfaces, regardless of the biopolymers special crystallization characteristics.
An axiomatic approach to Markov decision processes
Authors: Jonsson Adam
Published: December 2022

This paper presents an axiomatic approach to finite Markov decision processes where the discount rate is zero. One of the principal difficulties in the no discounting case is that, even if attention is restricted to stationary policies, a strong overtaking optimal policy need not exists. We provide preference foundations for two criteria that do admit optimal policies: 0-discount optimality and average overtaking optimality. As a corollary of our results, we obtain conditions on a decision maker’s preferences which ensure that an optimal policy exists. These results have implications for disciplines where dynamic programming problems arise, including automatic control, dynamic games, and economic development.
Utility of high-resolution magnetic resonance vessel wall imaging in differentiating between atherosclerotic plaques, vasculitis, and arterial dissection
Authors: Tritanon Oranan , Mataeng Suphanika , Apirakkan Mungkorn , Panyaping Theeraphol
Published: December 2022

Purpose

Differentiating between atherosclerosis, vasculitis, and dissection is a diagnostic challenge because of inconclusive findings on conventional imaging and some overlap in the vessel wall patterns. The aim of this study was to determine whether vessel wall MRI patterns can differentiate between these vasculopathies.

Methods

We retrospectively reviewed 3T high-resolution vessel wall imaging studies of patients diagnosed with atherosclerotic plaques, vasculitis, and dissection. The patterns of involvement, wall enhancement, and T1 and T2 signals, as well as the specific patterns, were assessed and compared between the three diseases.

Results

Fifty-nine patients with atherosclerosis (n = 33), vasculitis (n = 13), and dissection (n = 13) were enrolled. There were significant differences in the pattern of involvement between the three groups (P < 0.001), with concentric wall thickening in vasculitis patients (84.6%) and eccentric wall thickening in atherosclerosis (97%) and dissection (92.3%) patients. There was also a significant difference in the specific pattern (P < 0.001), with intimal flap (76.9%) and intramural hematoma (23.1%) in dissection patients and intraplaque hemorrhage (18.2%) in atherosclerosis patients. Furthermore, subgroup analysis showed a significant difference in the wall enhancement pattern between atherosclerosis and vasculitis patients (P < 0.05). Finally, there was a significant difference in the location of involvement between the three groups (P < 0.001).

Conclusion

By using the pattern of involvement, wall enhancement, and specific patterns, vessel wall MRI can help differentiate between atherosclerosis, vasculitis, and dissection.
Clinical performance of the Femoral Neck System within 1 year in 125 patients with acute femoral neck fractures, a prospective observational case series
Authors: Stoffel Karl , Michelitsch Christian , Arora Rohit , Babst Reto , Candrian Christian , Eickhoff Alexander , Gebhard Florian , Platz Andreas , Schmid Florian Andreas , Weschenfelder Wolfram , Sommer Christoph
Published: December 2022

Introduction

Osteosynthesis of femoral neck fractures (FNFs) is an important treatment option, especially for younger patients. We aimed to assess the rate of early implant-related complications in FNF osteosynthesis using the Femoral Neck System (FNS).

Patients and methods

Consecutive patients diagnosed with displaced or nondisplaced FNFs were treated with FNS in this prospective, observational, multicenter investigation. Patients were followed up for minimally 3 months and up to 12 months if radiologic bone union and no pain was not achieved beforehand. Predefined treatment-related adverse events (AEs, defined as implant failure, loss of reduction, iatrogenic fractures, deep infection, and surgical revision), radiologic bone union, and patient-reported Harris hip score (HHS) and EQ-5D-5L index score were assessed.

Results

One hundred and twenty-five patients were included in the study. Thirty-eight (30.4%) fractures were displaced (Garden III and IV), and 37 (29.6%) were vertical fractures (Pauwels type III). Predefined treatment-related AE rate at 3 months was 8 patients, 6.4% (95% CI, 2.8–12.2), and at 12 months, 11 patients, 8.8% (95% CI, 4.5–15.2). Cumulative incidences of bone union were 68% at 3 months, 90% at 6 months, and 98% at 12 months. The mean changes of HHS and EQ-5D-5L index score between preinjury and at 12 months were -7.5 (95% CI, [ – 21.1] to [6.2]) and  – 0.03 (95% CI, [ – 0.21] to [0.15]), respectively; neither were statistically significant.

Conclusion

The current study on osteosynthesis of FNFs with the FNS resulted in treatment-related complication rates of 6.4% (95% CI, 2.8–12.2) at 3 months and 8.8% (95% CI, 4.5–15.2) at 12 months. On average, patients returned to preinjury function and quality of life. The current study may also indicate that the conventional wisdom of treating stable FNF in patients aged between 60 and 80 years with osteosynthesis may need to be reconsidered.

Registration

The study is registered with ClinicalTrials.gov (registration number: NCT02422355).
Retrospective evaluation of radiological and clinical outcomes after surgical treatment of proximal femur fractures utilizing TFNA
Authors: Schneider Friedemann , Geir Fabian , Koidl Christian , Gehrer Luise , Runer Armin , Arora Rohit
Published: December 2022

Introduction

The aim of this study was to evaluate the clinical and radiological outcomes of patients treated with the TFN-Advanced™ Proximal Femoral Nailing system (TFNA¸ DePuy Synthes, West Chester, PA) including intra- and postoperative complications.

Materials and methods

All patients with an acute proximal femur fracture consequently treated with a TFNA between September 2014 and December 2018 were evaluated. Clinical and radiological data were assessed for intra- and postoperative complications, including treatment failure. In addition, intra- and postoperative X-rays were used to determine the position of the implant, and any migration, via tip-apex-distance (TAD) and the caput-collum-diaphyseal angle (CCD). The accuracy of the fracture reduction was rated by both observers according to Baumgartners criteria.

Results

275 consecutive patients (mean age 77.5 ± 14.1; 70.2% female) were included. The predominant OTA/AO fracture classification was 31A2 (140 cases, 50.7%). The average surgical time was 69 min (± 39.8). The reduction quality was good in 253 cases (92.0%) and acceptable in 22 cases (8.0%). In 18 cases, a pre-defined primary outcome parameter (6.5%) was recorded after a mean of 8.2 ± 8.0 months. During the observational period, 19 patients (6.9%) required a total of 23 additional surgeries. Implant removal was not considered a failure in the absence of pain. Significant group differences were observed with younger age (p = 0.001), lower Charlson Comorbidity Index (CCI)-score (p = 0.041) and lower rate of osteoporosis (p = 0.015) in the failure group. There were no cases of cut-out or cut-through among the patients who underwent augmentation as part of osteosynthesis.

Conclusions

Proximal femur fractures treated with the TFNA show low complication rates and high levels of radiological healing. Implant-related complications might be more common in patients with younger age, a lower CCI-score and lower frequency of osteoporosis. Usage of cement augmentation could potentially be beneficial to reduce postoperative cut-through and cut-out.
Historical and current issues in HIV encephalitis, and the role of neuropathology in HIV disease: a pathological perspective
Authors: Lucas Sebastian
Published: December 2022

In the 1980s, after the HIV pandemic was recognised, neuropathology identified cerebral white matter lesions that were found in the brains of infected persons with a severe irreversible dementia syndrome, this became known as ‘HIV encephalitis’. Subsequent work in Europe and north America found subtle morphological abnormalities in cerebral neurones and their connections. With the advent of effective anti-retroviral therapies after 1996, the incidence of severe HIV-related dementia declined, as did investigative tissue pathology into this HIV brain disease. Currently, the intense interest over HIV neurocognitive impairment focuses on neuroimaging, comparative blood and cerebrospinal fluid analysis, viral subtype analysis, and the search for biomarkers that correlate with brain function. Tissue neuropathology in HIV is more restricted to the diagnosis of acute disease such as opportunistic infections and tumours, and confirmation of the acute CD8 + T-cell encephalitis syndrome. But correlative tissue pathology will still be needed as newer therapeutic measures are developed to prevent and manage chronic HIV brain impairment.
Assessment of fluid status in neonatal dialysis: the need for new tools
Authors: Nourbakhsh Noureddin , Benador Nadine
Published: December 2022

Background

Assessment of fluid status in neonatal dialysis has largely focused on traditional tools including clinical assessment, serial weights, and blood pressure (BP) measurements. However, in infants on kidney replacement therapy, the assessment of fluid overload is problematic due to errors in weight assessment, subtlety of physical exam findings, and inaccuracy of non-invasive BP measurements.

Case summary

In this presentation of a neonate with bilateral renal agenesis requiring kidney replacement therapy, the treating team assessed a number of variables in determining the ultrafiltration prescription for dialysis across 2 modalities (hemodialysis and continuous kidney replacement therapy).

Complications

Fluid overload, cardiomegaly, and worsened respiratory status occurred when attempting to assess the neonate’s fluid status by traditional markers (weights, blood pressures, physical exam findings). B-type natriuretic peptide (BNP) was obtained and was noted to correlate with the degree of fluid overload.

Key management points

Compared to traditional tools for assessment of fluid status in pediatric dialysis, BNP assisted the medical team in optimizing the volume status of the subject and determining optimal daily ultrafiltration goals. Due to the rapid release in response to myocardial stretch and the lack of kidney clearance of the peptide, BNP may represent an objective, timely, and reliable index of volume status in the pediatric dialysis patient.
Medizin und die Zeitlichkeit guten Lebens in populären Fernsehnarrativen
Authors: Hißnauer Christian , Stockinger Claudia
Published: December 2022

Der Beitrag geht von der These aus, dass Arzt- und Krankenhausserien (sog. medicals) das Wechselverhältnis von Medizin und den Vorstellungen eines guten Lebens in der Zeit verhandeln. Dabei popularisieren sie als „institutionalisierter Interdiskurs“ (Link 1988) nicht nur medizinisches Wissen, sondern ebenso Haltungen zu medizinethischen Fragen. Sie sind als Formen einer „Medienmedizin“ (Wulff 2001) zu begreifen, die medienspezifischen Gestaltungskonventionen folgen. Für die Analyse von Fernsehserien genügt es nicht, explizite Stellungnahmen (etwa in der Figurenrede) zu beachten; vielmehr sind neben visuellen Aspekten insbesondere auch das Genre, die Dramaturgie und die Figurenkonstellation zu berücksichtigen. Am Beispiel einer Folge der ARD-Serie In aller Freundschaft (D, seit 1998) wird veranschaulicht, wie die verschiedenen Elemente ineinandergreifen, um innerhalb der Erzählung einen bestimmten Wertehorizont zu etablieren.
Circular Economy trifft urban-regionale Resilienz – Synergien für eine nachhaltig-anpassungsfähige Stadtentwicklung
Authors: Fromhold-Eisebith Martina
Published: December 2022

Um der Circular Economy bessere Möglichkeiten zur Integration in stadtregionale Strategien zu verschaffen, bietet sich die Verknüpfung mit weiter gefassten Zielen der Resilienz an. Die Konzepte der Urbanen und Regionalen Resilienz werden auch in Deutschland zunehmend als Ansatz für Zukunftsfähigkeit diskutiert. Sie sollen die Robustheit, Anpassungs- und Erholungsfähigkeit von Städten bzw. Regionen im Angesicht vielfältiger Krisen stärken, verknüpft mit Zielen der nachhaltigen Entwicklung. Der Beitrag zeigt einerseits auf, in welcher Hinsicht die kombinierte Sicht auf urban-regionale Resilienz einen geeigneten Rahmen für die effektive Einbettung systemischer Ansätze der Circular Economy ins stadträumliche Gefüge schafft. Andererseits wird erläutert, wie im Gegenzug auch die resiliente Abfederung umwelt- und wirtschaftsbezogener Risiken besser gelingen kann, wenn kreislaufwirtschaftliche Elemente integriert werden. Nach konzeptionellen Überlegungen zu synergetischen Wechselwirkungen dieser Prozessfelder dient das Beispiel der Stadt Aachen zur Illustration der zweckmäßigen Kombination von „Circular City“ und resilienzbezogenen Zielen. Dies macht deutlich, wie bedeutsam ein Fokus auf Innovationen für solche Strategieansätze ist. Am Ende werden Empfehlungen zur Gestaltung einer resilient-zirkulären Stadtökonomie formuliert.
Longitudinal changes in vitamin D concentrations and the association with type 2 diabetes mellitus: the Tromsø Study
Authors: Allaoui Giovanni , Rylander Charlotta , Fuskevåg Ole-Martin , Averina Maria , Wilsgaard Tom , Brustad Magritt , Jorde Rolf , Berg Vivian
Published: December 2022

Aim

We aimed to investigate the relationship between pre- and post-diagnostic 25-hydroxyvitamin D (25(OH)D) concentrations and type 2 diabetes (T2DM) over a period of 30 years in individuals who developed T2DM compared to healthy controls.

Methods

This case–control study included 254 participants with blood samples collected at five different time-points (T1–T5) between 1986 and 2016. Of the 254 participants, 116 were diagnosed with T2DM between T3 and T4, and were considered cases; the remaining 138 were controls. Linear mixed regression models were used to examine pre- and post-diagnostic changes in 25(OH)D concentrations, and logistic regression was used to examine associations between these concentrations and T2DM at each time-point.

Results

25(OH)D concentrations at different time-points and the longitudinal change in concentrations differed between cases and controls, and by sex. For women, each 5-nmol/l increase in 25(OH)D concentrations was inversely associated with T2DM at T3 (odds-ratio, OR, 0.79), whereas for men, this same increase was positively associated with T2DM at T1 (OR 1.12). Cases experienced a significant decrease in pre-diagnostic 25(OH)D concentrations (p value < 0.01 for women, p value = 0.02 for men) and a significant increase in post-diagnostic 25(OH)D concentrations (p value < 0.01 for women, p value = 0.01 for men). As such, each 1-unit increase in month-specific z-score change between T1 and T3 was significantly inversely associated with T2DM (OR 0.51 for women, OR 0.52 for men), and each such increase between T3 and T5 was significantly positively associated with T2DM in women (OR 2.48).

Conclusions

25(OH)D concentrations seem to be affected by disease progression and type 2 diabetes diagnosis.
Rapid detection of nanoplastics and small microplastics by Nile-Red staining and flow cytometry
Authors: Bianco Angelica , Carena Luca , Peitsaro Nina , Sordello Fabrizio , Vione Davide , Passananti Monica
Published: December 2022

Microplastics are of rising health concerns because they have been detected even in remote and pristine environments, from the Artic snow to the Marianne Trench. The occurrence and impact of nanoplastics in ecosystems is almost unknown, in particular due to analytical limitations such as very small sizes that fall below detection limits of current techniques. Here we take advantage of a common interference in analytical flow cytometry to develop a method for the quantification of the number of plastic particles in the 0.6–15 µm size range. Plastic particles are stained with the lipophilic dye Nile-Red then detected by flow cytometry, a method regularly used in biology for rapid quantification of fluorescent cells. We found that sample analysis lasts 90 s, which is hundreds of times faster than the analysis of filter portions by micro-Raman and other spectroscopic techniques. Our method is highly efficient in detecting polyethylene, with staining efficiency higher than 70% and signal linearity with concentration. Staining efficiency up to 96% was observed for polyvinylchloride and for polystyrene.
Assessment of fungal aerosols in a public library with natural ventilation
Authors: Camargo Caicedo Yiniva , Borja Pérez Hilary , Muñoz Fuentes Maryann , Vergara-Vásquez Eliana , Vélez-Pereira Andrés M.
Published: December 2022

Fungal aerosols deteriorate library collections and can impact human health, mainly via respiratory diseases. Their spread is influenced by factors such as temperature and relative humidity. This study aims to assess the concentration of fungal aerosols in the interior environment of the Popular Library of Gaira in the District of Santa Marta, Colombia, using a two-stage cascade impactor utilizing Sabouraud dextrose agar on Petri dishes for the collection of samples. The sampler was positioned at 1.5 m above ground level, operated with a flow rate of 28.3 l/min for 4 min and thermo-hygrometric conditions were also recorded. Concentrations in the air of up to 1197.0 CFU/m3 were reported, with a mean value close to 150 CFU/m3. Higher values during the morning samples were noted. Seven genera of fungi were found, Aspergillus and Curvularia were the most abundant. The temperature was between 30.80 and 33.51 °C, and the relative humidity was between 62.61 and 64.80%. Statistical analysis showed a significant correlation between the fungal aerosol concentration and relative humidity, where an increase of 10% in moisture could double the fungal aerosol concentration. We concluded that potentially favorable conditions exist indoors for the growth and survival of the following fungi: Aspergillus, Penicillium, Cladosporium, and Curvularia, and to a lesser extent for Chrysonilia, Cunninghamella, and Paecylomices. Relative humidity was seen to be the factor that affects the concentration of aerosols fungal in the library most significantly.
Proinflammatory activity of VEGF-targeted treatment through reversal of tumor endothelial cell anergy
Authors: Nowak-Sliwinska Patrycja , van Beijnum Judy R. , Griffioen Christian J. , Huinen Zowi R. , Sopesens Nadine Grima , Schulz Ralph , Jenkins Samir V. , Dings Ruud P. M. , Groenendijk Floris H. , Huijbers Elisabeth J. M. , Thijssen Victor L. J. L. , Jonasch Eric , Vyth-Dreese Florry A. , Jordanova Ekaterina S. , Bex Axel , Bernards René , de Gruijl Tanja D. , Griffioen Arjan W.
Published: December 2022

Purpose

Ongoing angiogenesis renders the tumor endothelium unresponsive to inflammatory cytokines and interferes with adhesion of leukocytes, resulting in escape from immunity. This process is referred to as tumor endothelial cell anergy. We aimed to investigate whether anti-angiogenic agents can overcome endothelial cell anergy and provide pro-inflammatory conditions.

Experimental design

Tissues of renal cell carcinoma (RCC) patients treated with VEGF pathway-targeted drugs and control tissues were subject to RNAseq and immunohistochemical profiling of the leukocyte infiltrate. Analysis of adhesion molecule regulation in cultured endothelial cells, in a preclinical model and in human tissues was performed and correlated to leukocyte infiltration.

Results

It is shown that treatment of RCC patients with the drugs sunitinib or bevacizumab overcomes tumor endothelial cell anergy. This treatment resulted in an augmented inflammatory state of the tumor, characterized by enhanced infiltration of all major leukocyte subsets, including T cells, regulatory T cells, macrophages of both M1- and M2-like phenotypes and activated dendritic cells. In vitro, exposure of angiogenic endothelial cells to anti-angiogenic drugs normalized ICAM-1 expression. In addition, a panel of tyrosine kinase inhibitors was shown to increase transendothelial migration of both non-adherent and monocytic leukocytes. In primary tumors of RCC patients, ICAM-1 expression was found to be significantly increased in both the sunitinib and bevacizumab-treated groups. Genomic analysis confirmed the correlation between increased immune cell infiltration and ICAM-1 expression upon VEGF-targeted treatment.

Conclusion

The results support the emerging concept that anti-angiogenic therapy can boost immunity and show how immunotherapy approaches can benefit from combination with anti-angiogenic compounds.
Characterizing the Impact of the COVID-19 Pandemic on HIV PrEP care: A Review and Synthesis of the Literature
Authors: Hong Chenglin
Published: December 2022

The global COVID-19 pandemic and associated lockdown measures have caused disruptions to sexual health services and created additional barriers to the continuity of HIV pre-exposure prophylaxis (PrEP) among key populations. This review provides an examination of the influences of the pandemic on engagement in the PrEP care continuum. Using the PRISMA guideline, 46 studies were included in this review and the synthesis. Most of the studies were conducted in high-income settings through quantitative analysis. A majority of studies examining the changes in PrEP use suggested a decline or discontinuation in PrEP uptake during the pandemic. The most common reasons for stopping using PrEP were perceived barriers to PrEP-related care, having reduced sexual behaviors and fewer sexual partners, and reduced perceived risk of HIV infection. Limited studies documenting an increase in PrEP uptake were all in specific PrEP optimizing programs. During the pandemic, there is also an emerging trend of switching to on-demand PrEP from daily oral PrEP. Future studies should understand the mechanism of strategies that facilitated the improvements during the pandemic. PrEP implementation programs should consider alternative PrEP modalities and provide consistent and comprehensive knowledge about correct information.
Pamiparib in patients with locally advanced or metastatic HER2-negative breast cancer with germline BRCA mutations: a phase II study
Authors: Xu Binghe , Sun Tao , Shi Yanxia , Cui Jiuwei , Yin Yongmei , Ouyang Quchang , Liu Qiang , Zhang Qingyuan , Chen Yiding , Wang Shouman , Wang Xiaojia , Tong Zhongsheng , Zhong Yahua , Wang Jiayu , Yan Min , Yan Xi , Wang Chuan , Feng Jifeng , Wang Xiuli , Hu Gang , Cheng Ying , Ge Ruimin , Zhu Zhaoyin , Zhang Wa , Shao Zhimin
Published: December 2022

Purpose

To evaluate the efficacy and safety of pamiparib in patients with locally advanced or metastatic human epidermal growth factor receptor 2-negative (HER2−) breast cancer, with deleterious or suspected deleterious germline BRCA1/2 mutations (gBRCA1/2 m).

Methods

In this open-label, phase II, multicenter study in China (NCT03575065), patients with triple-negative breast cancer (TNBC cohort) or hormone receptor-positive (HR+)/HER2− breast cancer (HR+/HER2− cohort) and ≤ 2 prior lines of chemotherapy received pamiparib 60 mg orally twice daily in 28-day, continuous cycles. The primary endpoint was objective response rate (ORR; RECIST v1.1) by independent review committee.

Results

In total, 88 patients were enrolled (TNBC cohort: 62; HR+/HER2− cohort: 26). Median age was 45.5 (range: 27–67) years, and 60 patients (68.2%) had received 1 or 2 prior lines of chemotherapy; 42 patients (47.7%) had previously received platinum chemotherapy. In the TNBC cohort, ORR was 38.2% (95% confidence interval [CI] 25.4–52.3) and median duration of response (DoR) was 7.0 months (95% CI 3.9–not estimable). In the HR+/HER2− cohort, ORR was 61.9% (95% CI 38.4–81.9) and median DoR was 7.5 months (95% CI 5.6–14.8). The most common treatment-emergent adverse events (TEAEs), treatment-related TEAEs, and ≥ Grade 3 TEAEs were hematologic (including anemia, decreased neutrophil count, and decreased white blood cell count). Overall, 64.8% of patients had TEAEs leading to dose reduction and 2.3% had TEAEs leading to treatment discontinuation.

Conclusion

Pamiparib showed encouraging efficacy and an acceptable safety profile in patients with locally advanced and metastatic HER2− breast cancer with gBRCA1/2 m.

Trial registration

ClinicalTrials.gov, NCT03575065; July 2, 2018.
Oil structuring properties of electrospun Kraft lignin/cellulose acetate nanofibers for lubricating applications: influence of lignin source and lignin/cellulose acetate ratio
Authors: Rubio-Valle J. F. , Valencia C. , Sánchez M. , Martín-Alfonso J. E. , Franco J. M.
Published: December 2022

In the present work, electrospun Kraft lignin/cellulose acetate nanostructures were produced, assessed and proposed as structuring or thickening agents of castor oil for lubricating applications. Solutions of Kraft lignins (KL) derived from different sources (eucalyptus, poplar and olive tree pruning) and cellulose acetate (CA) were prepared and used as feed for electrospinning. The rheological properties (shear and extensional viscosity), electrical conductivity and surface tension of KL/CA solutions influence the morphology of the electrospun nanofibers, which in turn is affected by the chemical structure and composition of the Kraft lignins. Electrospun KL/CA nanostructures consisting of filament-interconnected nanoparticles, beaded nanofibers or uniform nanofiber mats were able to form gel-like homogeneous fine dispersions by simply mechanically dispersing them into castor oil. The swelling of KL/CA nanofibers in the percolation network was demonstrated. The rheological, tribological and microstructural properties of these oleogels are essentially governed by the morphological characteristics of the electrospun nanostructures, i.e. fiber diameter, number of beads and porosity. Rheological properties of the resulting oleogels may be tailored by modifying the lignin source and KL:CA weight ratio. According to their rheological and tribological properties, KL/CA electrospun nanostructures-based oleogels can be proposed as a sustainable alternative to conventional lubricating greases.
Forecast evaluation for data scientists: common pitfalls and best practices
Authors: Hewamalage Hansika , Ackermann Klaus , Bergmeir Christoph
Published: December 2022

Recent trends in the Machine Learning (ML) and in particular Deep Learning (DL) domains have demonstrated that with the availability of massive amounts of time series, ML and DL techniques are competitive in time series forecasting. Nevertheless, the different forms of non-stationarities associated with time series challenge the capabilities of data-driven ML models. Furthermore, due to the domain of forecasting being fostered mainly by statisticians and econometricians over the years, the concepts related to forecast evaluation are not the mainstream knowledge among ML researchers. We demonstrate in our work that as a consequence, ML researchers oftentimes adopt flawed evaluation practices which results in spurious conclusions suggesting methods that are not competitive in reality to be seemingly competitive. Therefore, in this work we provide a tutorial-like compilation of the details associated with forecast evaluation. This way, we intend to impart the information associated with forecast evaluation to fit the context of ML, as means of bridging the knowledge gap between traditional methods of forecasting and adopting current state-of-the-art ML techniques.We elaborate the details of the different problematic characteristics of time series such as non-normality and non-stationarities and how they are associated with common pitfalls in forecast evaluation. Best practices in forecast evaluation are outlined with respect to the different steps such as data partitioning, error calculation, statistical testing, and others. Further guidelines are also provided along selecting valid and suitable error measures depending on the specific characteristics of the dataset at hand.
Parametric Amplification via Superconducting Contacts in a Ka Band Niobium Pillbox Cavity
Authors: Gilles V. , Banys D. , McCulloch M. A. , Piccirillo L. , Sweetnam T.
Published: December 2022

Superconducting parametric amplifiers are commonly fabricated using planar transmission lines with a nonlinear inductance provided by either Josephson junctions or the intrinsic kinetic inductance of the thin film. However, Banys et al. (J Low Temp Phys, 2020) reported nonlinear behaviour in a niobium pillbox cavity, hypothesising that below $$T_c$$

T
c

, the pair iris-bulk resonator would act as a superconducting contact surface exploiting a Josephson-like nonlinearity. This work investigates this effect further by applying Keysight Technologies’ Advanced Design System (ADS) to simulate the cavity using an equivalent circuit model that includes a user defined Josephson inductance component. The simulations show that for a resonance centred at $$\nu _0=30.649$$

ν
0

=
30.649

GHz, when two tones (pump and signal) are injected into the cavity, mixing and parametric gain occur. The maximum achievable gain is explored when the resonator is taken to its bifurcation energy. These results are compared to cryogenic measurements where the pump and the signal are provided by a Vector Network Analyzer.
Development of polymer electrolyte membrane based on poly(Vinyl Chloride)/graphene oxide modified with zirconium phosphate for fuel cell applications
Authors: Elerian Ahmed F. , Abu-Saied M. A. , Abd-Elnaim G. H. , Elnaggar Elsayed M.
Published: December 2022

The function of a membrane in the fuel cell is critical to its success. The major component of a direct methanol fuel cell (DMFC) is the proton exchange membrane (PEM) which must have proton conductivity, thermal stability, mechanical qualities, and low methanol permeability. In this study case, the film-forming and structural properties of Polyvinyl chloride (PVC) impelled us to employ them for developing polyelectrolyte membranes (PEMs). To functionalize the resultant PEMs, Graphene oxide (GO) and zirconium phosphate (ZrP) were incorporated into polyvinyl chloride in different proportions. The structural and physical properties of PVC/GO-ZrP membranes were investigated by using a variety of techniques instance, Fourier transform infrared spectroscopy (FTIR), Scanning electron microscope (SEM), Transmission electron microscope (TEM), Thermogravimetric analyzer (TGA), universal testing machine, and water contact angle meter. Furthermore, water uptake, Methanol uptake, and ion exchange capacity (IEC) were measured. The results demonstrated that the membranes developed have enough characteristics to be valid in DMFCs.
The phenomenology of maintenance goals: lower threat and greater satisfaction with the current state
Authors: Ecker Yael , Gilead Michael , Imhoff Roland
Published: December 2022

This research tested the mental experience of maintenance goals as distinct from goals to approach better outcomes (approach goals) and goals to avoid worse outcomes (avoidance goals). In Studies 1 and 2, participants reported personal goals and categorized them as one of the three goal types. We theorized that maintenance centers on existing positive outcomes, while avoidance centers on future (expected) negative outcomes. We therefore predicted a lesser experience of threat and a greater experience of satisfaction in maintenance compared to avoidance. Additionally, we predicted greater satisfaction in maintenance compared to approach goals, wherein motivation comes from the value of future (desired) positive outcomes rather than current ones. Confirming our predictions, participants rated personal maintenance goals as lower on threat (Study 1) and higher on satisfaction (Studies 1 and 2) compared to avoidance goals. Additionally, revealing the centrality of maintenance, maintenance goals played a major role in reported central life goals (Study 1) and the largest role in goals pursued in the previous week (Study 2). Finally, in Study 3, participants judged another person engaged in maintenance as more satisfied and less threatened than a person engaged in avoidance or approach. Taken together, this work informs about the phenomenological nature of maintenance and advances a theory-driven ternary taxonomy of basic goal types.
Impact of using authentic online learning environments on students’ perceived employability
Authors: Martínez-Argüelles María-Jesús , Plana-Erta Dolors , Fitó-Bertran Àngels
Published: December 2022

The digitalization and globalization of society and the corresponding impact on the rules of the labor market is shifting the education sector toward new pedagogical approaches that integrate wholly online methodologies. Sustainable Development Goal 4 advocates for inclusive and equitable quality education that promotes lifelong learning opportunities, and, as we have seen during the COVID-19 lockdown, online learning can play a key role. In a context where lifelong learning becomes crucial to maintaining graduates’ employability, the innovative teaching methodologies that promote employable competencies in online environments are especially desirable. With the purpose of improving the employability of students, this article analyses the impact of introducing the Authentic Learning Scenarios (ALS) paradigm in an online environment. We develop a quasi-experimental design. Based on the nine ALS criteria and their application to e-learning, we redesign a course in a business degree program. Data from 135 students were collected, with special focus on achieving general competences. We compare the perception of the competency profile attained between a group of students who took the course before incorporating the ALS paradigm and another group that took it once it had been redesigned. Results show that redesigning the course enables students to perceive the learning process as more authentic, as well as acquiring a more advanced competence profile. Besides this, it has been shown that technology can contribute to building cognitive authenticity in virtual classrooms, without the need for face-to-face internships, which are often not a feasible option for students of online programs.
The Impact of Linguistic Form of Labels on Desire for Social Distance in Mental Health
Authors: Mallinson Matt Geoffrey , Giannakopoulou Anastasia , Clements Andrew James
Published: December 2022

The American Psychological Association, among other influential bodies, make recommendations on language for describing people with mental health conditions. The present studies test the impact of the recommended language on stigma. In Study 1, participants (n = 294) were asked to complete measures of desire for social distance from individuals given a diagnostic label in either person-first possessive, identity-first noun, or identity-first adjective forms. Familiarity with the diagnoses was considered as a potential influence on the outcome. The 3*2 (linguistic form * experience) factorial design was repeated for three diagnoses - schizophrenia, anorexia and alcoholism. In Study 2, the research was replicated with a sample recruited from the UK population via social media (n = 230). Factorial ANOVA was used for analysis. In contrast with previous literature, the studies found neither an effect of linguistic form (hypothesis 1) nor an interaction effect with familiarity (hypothesis 2). Research on this topic is in an early stage and, above all, it remains important to use language, which shows respect when talking to or about others.
Tungsten-Steel Functionally Graded Coatings for Nuclear Fusion Applications Manufactured by Cold Gas Spraying
Authors: Mauer Georg , Rauwald Karl-Heinz , Sohn Yoo Jung
Published: December 2022

In nuclear fusion reactors, the first wall is the name given to the surface which is in direct contact with the plasma. A part of it is the divertor which is a device that removes fusion products from the plasma and impurities that have entered into it from the vessel lining. It is covered with water cooled tiles which have to withstand high temperatures and high heat fluxes. Moreover, resistance to neutron bombardment, low tritium absorption and low hydrogen permeation are additional demands. One materials concept under research is the application of a Reduced Activation Ferritic Martensitic Steel (RAFM) as a structural material with a tungsten protective coating. Since there is a considerable thermal mismatch between, a functional-graded materials concept was proposed.

As the formation of undesired intermetallic Fe-W phases as well as oxidation should be avoided, cold gas spraying was chosen as manufacturing process. Two powder blends of EUROFER97 RAFM steel and a fine tungsten powder cut on the one hand and a coarser one on the other hand were tested in different ratios. The coatings were characterized with respect to their porosity and surface structure. Furthermore, the deposition efficiencies for steel and tungsten were determined each. It turned out that the deposition process is a complex mixed situation of bonding and erosion mechanisms as the deposition windows of these very different materials obviously diverge. Thus, a lower working gas temperature and pressure was advantageous in some cases. Unexpectedly, the coarser tungsten powder in general enabled to achieve better results.
Out-of-pocket payments and loss of income among long-term breast cancer survivors in Germany: a multi-regional population-based study
Authors: Schneider Jana , Hernandez Diego ,   CAESAR study group, Schlander Michael , Arndt Volker ,   on behalf of the CEASAR study group
Published: December 2022

Purpose

This study aims to examine the magnitude of out of pocket (OOP) payments and income loss, as well as to identify socioeconomic and clinical factors among long-term breast cancer (BC) survivors in Germany.

Methods

We examine data from 2654 long-term BC survivors in Germany that participated in the “CAncEr Survivorship – A multi-Regional population-based study” (CAESAR) and who were at least 5 years post diagnosis. BC-related OOP payments and income loss both within the 12 months prior to the survey were analyzed. Two-part regression models were performed to identify socioeconomic and clinical factors.

Results

OOP payments were incurred by 51.9% of survivors with a total mean spending of 566 euros. Income loss was present among 9.6% of survivors and averaged 5463 euros among those reporting such. Socioeconomic and clinical factors associated with higher OOP payments (p ≤ 0.05) included age at time of diagnosis (65–79 years), education (10–11 years), (early) retirement, stage of diagnosis (stage III), time from diagnosis (more than 10 years), comorbidities (at least 1), and the use of rehabilitation services. Regarding income loss, age at time of diagnosis (50–59 years), (early) retirement, stage of diagnosis (stage II), time from diagnosis (5–7 years), comorbidities (at least 1), and receiving chemotherapy treatment were associated with higher losses.

Conclusions

For some survivors in Germany, financial burden can be considerably high despite comprehensive healthcare and support from social security.

Implications for Cancer Survivors

OOP payments related to domestic help and nursing staff as well as to outpatient care are most frequent.
Effects of gastric bypass surgery on brain connectivity responses to hypoglycemia
Authors: Fanni Giovanni , Kagios Christakis , Roman Erika , Sundbom Magnus , Wikström Johan , Haller Sven , Eriksson Jan W.
Published: December 2022

Introduction

Roux-en-Y gastric bypass (RYGB) leads to beneficial effects on glucose homeostasis, and attenuated hormonal counterregulatory responses to hypoglycemia are likely to contribute. RYGB also induces alterations in neural activity of cortical and subcortical brain regions. We aimed to characterize RYGB-induced changes in resting-state connectivity of specific brain regions of interest for energy homeostasis and behavioral control during hypoglycemia.

Method

Ten patients with BMI > 35 kg/m2 were investigated with brain PET/MR imaging during a hyperinsulinemic normo- and hypoglycemic clamp, before and 4 months after RYGB. Hormonal levels were assessed throughout the clamp. Resting-state (RS) fMRI scans were acquired in the glucose-lowering phase of the clamp, and they were analyzed with a seed-to-voxel approach.

Results

RS connectivity during initiation of hypoglycemia was significantly altered after RYGB between nucleus accumbens, thalamus, caudate, hypothalamus and their crosstalk with cortical and subcortical regions. Connectivity between the nucleus accumbens and the frontal pole was increased after RYGB, and this was associated with a reduction of ACTH (r = −0.639, p = 0.047) and cortisol (r = −0.635, p = 0.048) responses. Instead, connectivity between the caudate and the frontal pole after RYGB was reduced and this was associated with less attenuation of glucagon response during the hypoglycemic clamp (r = −0.728, p = 0.017), smaller reduction in fasting glucose (r = −0.798, p = 0.007) and less excess weight loss (r = 0.753, p = 0.012). No other significant associations were found between post-RYGB changes in ROI-to-voxel regional connectivity hormonal responses and metabolic or anthropometric outcomes.

Conclusion

RYGB alters brain connectivity during hypoglycemia of several neural pathways involved in reward, inhibitory control, and energy homeostasis. These changes are associated with altered hormonal responses to hypoglycemia and may be involved in the glucometabolic outcome of RYGB.
Endogenous hyperinsulinemic hypoglycemia: case series and literature review
Authors: Zhang Chenyang , Zhang Hui , Huang Wen
Published: December 2022

Purpose

Endogenous hyperinsulinemic hypoglycemia (EHH) is an uncommon disease characterized by inappropriately high plasma insulin levels despite low plasma glucose levels. Some rare etiologies can lead to EHH. Correct diagnosis is a prerequisite for treatment. Hence, although challenging, it is crucial for patients with EHH to identify the different causes.

Methods

We describe a case series of three patients, all of whom had obvious hypoglycemic symptoms and extraordinary hyperinsulinemia. Their plasma glucose, insulin, and C-peptide levels were tested simultaneously when hypoglycemia occurred. Moreover, other biochemical indices and relevant antibody levels were measured and imaging examinations were conducted.

Results

According to their medical history, physical examination, laboratory results, and imaging findings, the three patients were diagnosed with insulinoma, type B insulin resistance syndrome, and insulin autoimmune syndrome. After precise treatments, hypoglycemia was ultimately eliminated.

Conclusion

Although these diseases have similar symptoms and biochemical abnormalities, the treatment and prognosis are different. The case series presented here highlights the challenges in the differential diagnosis of EHH. An accurate diagnosis is necessary for hypoglycemia treatment.
Vasopressin induces apoptosis but does not enhance the antiproliferative effect of dynamin 2 or PI3K/Akt inhibition in luminal A breast cancer cells
Authors: Alkafaas Samar Sami , Loutfy Samah A. , Diab Thoria , Hessien Mohamed
Published: December 2022

Breast cancer cells abnormally express vasopressin (AVP) and its receptors. The effect of AVP is largely orchestrated through its downstream signaling and by receptor-mediated endocytosis (RME), in which Dynamin 2 (Dyn2) plays an integral role in vesicle closure. In this work, luminal A breast cancer cells were treated with AVP, and then Dynasore (DYN) was employed to inhibit Dyn2 to explore the combined effect of AVP and Dyn2 inhibition on the survival of breast cancer cells. The results revealed that DYN alone demonstrated a concentration-dependent cytotoxic effect in AVP untreated cells. Apoptosis developed in 29.7 and 30.3% of cells treated with AVP or AVP+DYN, respectively, compared to 32.5% in cells treated with Wortmannin (Wort, a selective PI3K pathway inhibitor). More apoptosis was observed when cells were treated with DYN+Wort in presence or absence of exogenous AVP. Besides, 2 or 4- fold increases in the expression of Bax and Caspase-3, were observed in cells exposed to AVP in absence or presence of DYN, respectively. This was associated with higher levels of the autophagy marker (LC3II protein). Meanwhile, the activation of Akt protein, sequentially decreased in the same pattern. Cell’s invasion decreased when they were exposed to AVP alone or combined with DYN or/and Wort. Conclusively, although many reports suggested the proliferative effect of AVP, the results predict the antiproliferative and antimetastatic effects of 100 nM AVP in luminal A breast cancer cells. However, the hormone did not enhance the cytotoxic effect of Dyn 2 or PI3K pathway inhibition.

Graphical Abstract

Summary of the Dynamin 2 independent AVP antiproliferative effects. Breast cancer cells expresses AVP as a Prohormone (A). At high dose of AVP, the hormone is liganded with AVP receptor (B) to initiate RME, where the endosomed complex (C) is degraded through the endosome-lysosome system, as a part of signal management. These events consume soluble Dyn2 in neck closure and vesicle fission (D). This makes the cells more substitutable to the direct apoptotic effect of DYN (E). Alternatively, at lower AVP doses the liganded AVP may initiate cAMP-mediated downstream signaling (F) and cellular proliferation. In parallel, Wort inhibits PIP2-PIP3 conversion (G) and the subsequent inhibition of PI3K/Akt/mTOR pathway leading to cell death.