bluuebunny/crossref_metadata_2025 huggingface dataset:
Precise In-Process Strain Measurements for the Investigation of Surface Modification Mechanisms
Authors: Tausendfreund Andreas , Stöbener Dirk , Fischer Andreas
Published: January 2018

The question, how certain surface layer properties (for example, hardness or roughness) can be specifically influenced in different manufacturing processes, is of great economic interest. A prerequisite for the investigation of the formation of surface layer properties is the metrological assessment of the material stresses during processing. Up to now, no commercial in-process measuring system exists, which is able to determine material stresses in the form of mechanical strains in high-dynamic manufacturing processes with sufficient accuracy. A detailed analysis of the resolution limits shows that speckle photography enables deformation measurements with a resolution in the single-digit nanometer range. Thus, speckle photography basically offers the potential to measure material stresses during processing. Using the example of single-tooth milling, the applicability of speckle photography for in-process stress measurements is demonstrated. Even in such highly dynamic manufacturing processes with cutting speeds up to 10 m/s, the absolute measurement uncertainty of the strain is less than 0.05%. This is more than one order of magnitude lower than the occurring maximal strain. Therefore, speckle photography is suitable for characterizing the dynamic stresses and the material deformations in manufacturing processes.
A Novel Spectrally Efficient Asynchronous Multi-Channel MAC Using a Half-Duplex Transceiver for Wireless Networks
Authors: Devendiran Abdullah , Sheltami Tarek , Mahmoud Ashraf
Published: January 2018

Multi-channel medium access control (MAC) protocols maximize network performance by enabling concurrent wireless transmissions over non-interfering channels. Despite physical layer advancements, the underlying IEEE 802.11 MAC standard cannot fully exploit features and support high-performance applications. In this work, we propose the novel spectrally efficient asynchronous multi-channel MAC (SA-MMAC) protocol for wireless networks using a single half-duplex transceiver. A full-duplex mode of operation on data channels reduces the signaling overhead and boosts the spectrum efficiency. A revamped contention mechanism of IEEE 802.11 addresses the multi-channel hidden terminal problem, and a jamming signal from the receiver addresses the collisions in control signals. Furthermore, the control channel is used for data transmissions to increase the bandwidth utilization but under a restricted half-duplex mode to avoid causing a bottleneck situation. The simulator is tested for correctness. The results suggest that the protocol can work well on 3, 4, or 12 concurrent channels with high node density, providing about 12.5 times more throughput than IEEE 802.11 and 18% to 95% more throughput than its multi-channel variants under saturated traffic conditions.
Tribological Behaviors of Graphene and Graphene Oxide as Water-Based Lubricant Additives for Magnesium Alloy/Steel Contacts
Authors: Xie Hongmei , Jiang Bin , Dai Jiahong , Peng Cheng , Li Chunxia , Li Quan , Pan Fusheng
Published: January 2018

The tribological behaviors of graphene and graphene oxide (GO) as water-based lubricant additives were evaluated by use of a reciprocating ball-on-plate tribometer for magnesium alloy-steel contacts. Three sets of test conditions were examined to investigate the effect of concentration, the capacity of carrying load and the endurance of the lubrication film, respectively. The results showed that the tribological behaviors of water can be improved by adding the appropriate graphene or GO. Compared with pure deionized water, 0.5 wt.% graphene nanofluids can offer reduction of friction coefficient by 21.9% and reduction of wear rate by 13.5%. Meanwhile, 0.5 wt.% GO nanofluids were found to reduce the friction coefficient and wear rate up to 77.5% and 90%, respectively. Besides this, the positive effect of the GO nanofluids was also more pronounced in terms of the load-carrying capacity and the lubrication film endurance. The wear mechanisms have been tentatively proposed according to the observation of the worn surfaces by field emission scanning electron microscope-energy dispersive spectrometer (FESEM-EDS) and Raman spectrum as well as the wettability of the nanofluids on the magnesium alloy surface by goniometer.
Synthesis and Characterization of “Ravine-Like” BCN Compounds with High Capacitance
Authors: Chen Dongping , Huang Yanzhen , Hu Xinling , Li Rongkai , Qian Yingjiang , Li Dongxu
Published: January 2018

A series of “ravine-like” boron carbonitrides (abbreviation: BCN) were synthesized by a green precursor pyrolysis method at different temperatures (about 700–1100 °C). The highest electrochemical performance of BCN-800 (Named BCN-temperature) electrode was observed, because the “ravine-like” structure can significantly increase the contact area and improve the wettability between electrode and electrolyte. The BCN electrode exhibited ultrahigh specific capacitance 805.9 F/g (at a current density of 0.2 A/g), excellent rate capability, and good cycling stability (91%) after 3000 cycles at a current density of 8 A/g, showing high potential applications in supercapacitors.
Transparent Glass-Ceramics Produced by Sol-Gel: A Suitable Alternative for Photonic Materials
Authors: Gorni Giulio , Velázquez Jose , Mosa Jadra , Balda Rolindes , Fernández Joaquin , Durán Alicia , Castro Yolanda
Published: January 2018

Transparent glass-ceramics have shown interesting optical properties for several photonic applications. In particular, compositions based on oxide glass matrices with fluoride crystals embedded inside, known as oxyfluoride glass-ceramics, have gained increasing interest in the last few decades. Melt-quenching is still the most used method to prepare these materials but sol-gel has been indicated as a suitable alternative. Many papers have been published since the end of the 1990s, when these materials were prepared by sol-gel for the first time, thus a review of the achievements obtained so far is necessary. In the first part of this paper, a review of transparent sol-gel glass-ceramics is made focusing mainly on oxyfluoride compositions. Many interesting optical results have been obtained but very little innovation of synthesis and processing is found with respect to pioneering papers published 20 years ago. In the second part we describe the improvements in synthesis and processing obtained by the authors during the last five years. The main achievements are the preparation of oxyfluoride glass-ceramics with a much higher fluoride crystal fraction, at least double that reported up to now, and the first synthesis of NaGdF4 glass-ceramics. Moreover, a new SiO2 precursor was introduced in the synthesis, allowing for a reduction in the treatment temperature and favoring hydroxyl group removal. Interesting optical properties demonstrated the incorporation of dopant ions in the fluoride crystals, thus obtaining crystal-like spectra along with higher efficiencies with respect to xerogels, and hence demonstrating that these materials are a suitable alternative for photonic applications.
Predicting Observable Quantities of Self-Assembled Metamaterials from the T-Matrix of Its Constituting Meta-Atom
Authors: Suryadharma Radius , Rockstuhl Carsten
Published: January 2018

Self-assembled metamaterials attract considerable interest as they promise to make isotropic bulk metamaterials available at low costs. The optical response of self-assembled metamaterials is derived predominantly from the response of its individual constituents, i.e., the meta-atoms. Beyond effective properties, primary experimentally observable quantities, such as specific cross-sections, are at the focus of interest as they are frequently considered when exploiting metamaterials in specific applications. This posses the challenge of predicting these observable quantities for a diluted ensemble of randomly oriented meta-atoms. Thus far, this has been achieved by either averaging the optical response of the meta-atom across all possible incident fields or by restricting the consideration to only an electric and magnetic dipolar response. This, however, is either time-consuming or imposes an unnecessary limitation. Here, we solve this problem by deriving and presenting explicit expressions for experimentally observable quantities of metamaterials made from randomly arranged and oriented meta-atoms characterized by their T-matrix.
Simulation and Analysis of Mechanical Properties of Silica Aerogels: From Rationalization to Prediction
Authors: Ma Hao , Zheng Xiaoyang , Luo Xuan , Yi Yong , Yang Fan
Published: January 2018

Silica aerogels are highly porous 3D nanostructures and have exhibited excellent physio-chemical properties. Although silica aerogels have broad potential in many fields, the poor mechanical properties greatly limit further applications. In this study, we have applied the finite volume method (FVM) method to calculate the mechanical properties of silica aerogels with different geometric properties such as particle size, pore size, ligament diameter, etc. The FVM simulation results show that a power law correlation existing between relative density and mechanical properties (elastic modulus and yield stress) of silica aerogels, which are consistent with experimental and literature studies. In addition, depending on the relative densities, different strategies are proposed in order to synthesize silica aerogels with better mechanical performance by adjusting the distribution of pore size and ligament diameter of aerogels. Finally, the results suggest that it is possible to synthesize silica aerogels with ultra-low density as well as high strength and stiffness as long as the textural features are well controlled. It is believed that the FVM simulation methodology could be a valuable tool to study mechanical performance of silica aerogel based materials in the future.
Hydrophilicity, Viscoelastic, and Physicochemical Properties Variations in Dental Bone Grafting Substitutes
Authors: Trajkovski Branko , Jaunich Matthias , Müller Wolf-Dieter , Beuer Florian , Zafiropoulos Gregory-George , Houshmand Alireza
Published: January 2018

The indication-oriented Dental Bone Graft Substitutes (DBGS) selection, the correct bone defects classification, and appropriate treatment planning are very crucial for obtaining successful clinical results. However, hydrophilic, viscoelastic, and physicochemical properties’ influence on the DBGS regenerative potential has poorly been studied. For that reason, we investigated the dimensional changes and molecular mobility by Dynamic Mechanical Analysis (DMA) of xenograft (cerabone®), synthetic (maxresorb®), and allograft (maxgraft®, Puros®) blocks in a wet and dry state. While no significant differences could be seen in dry state, cerabone® and maxresorb® blocks showed a slight height decrease in wet state, whereas both maxgraft® and Puros® had an almost identical height increase. In addition, cerabone® and maxresorb® blocks remained highly rigid and their damping behaviour was not influenced by the water. On the other hand, both maxgraft® and Puros® had a strong increase in their molecular mobility with different damping behaviour profiles during the wet state. A high-speed microscopical imaging system was used to analyze the hydrophilicity in several naturally derived (cerabone®, Bio-Oss®, NuOss®, SIC® nature graft) and synthetic DBGS granules (maxresorb®, BoneCeramic®, NanoBone®, Ceros®). The highest level of hydrophilicity was detected in cerabone® and maxresorb®, while Bio-Oss® and BoneCeramic® had the lowest level of hydrophilicity among both naturally derived and synthetic DBGS groups. Deviations among the DBGS were also addressed via physicochemical differences recorded by Micro Computed Tomography, Scanning Electron Microscopy, Fourier Transform Infrared Spectroscopy, X-ray powder Diffractometry, and Thermogravimetric Analysis. Such DBGS variations could influence the volume stability at the grafting site, handling as well as the speed of vascularization and bone regeneration. Therefore, this study initiates a new insight into the DBGS differences and their importance for successful clinical results.
Mechanical Properties Optimization of Poly-Ether-Ether-Ketone via Fused Deposition Modeling
Authors: Deng Xiaohu , Zeng Zhi , Peng Bei , Yan Shuo , Ke Wenchao
Published: January 2018

Compared to the common selective laser sintering (SLS) manufacturing method, fused deposition modeling (FDM) seems to be an economical and efficient three-dimensional (3D) printing method for high temperature polymer materials in medical applications. In this work, a customized FDM system was developed for polyether-ether-ketone (PEEK) materials printing. The effects of printing speed, layer thickness, printing temperature and filling ratio on tensile properties were analyzed by the orthogonal test of four factors and three levels. Optimal tensile properties of the PEEK specimens were observed at a printing speed of 60 mm/s, layer thickness of 0.2 mm, temperature of 370 °C and filling ratio of 40%. Furthermore, the impact and bending tests were conducted under optimized conditions and the results demonstrated that the printed PEEK specimens have appropriate mechanical properties.
Fiducial-Aided Robust Positioning of Optical Freeform Surfaces
Authors: Wang Shixiang , Cheung Chi , Ren Mingjun , Liu Mingyu
Published: January 2018

Form characterization of a machined optical freeform surface demands accurate alignment of the sampled measured data points on the machined surface, and they are compared with the designed geometry of the surface through positioning. In this paper, a fiducial-aided robust positioning method (FAPM) is developed which attempts to evaluate freeform surfaces with high efficiency and precision. The FAPM method makes use of fiducials as reference datum to form a fiducial-aided computer-aided design (FA-CAD) of the freeform surface which not only establishes an inherent surface feature, but also links the different coordinate systems among design coordinate frame, machine tool, and measurement instrument. To verify the capability of the proposed method, a series of experiments were conducted. Compared with the traditional freeform measurement method (e.g., least squares method), the results indicate that the robustness and accuracy of the measurement is significantly enhanced by the FAPM.
Curcumin Analog CH-5 Suppresses the Proliferation, Migration, and Invasion of the Human Gastric Cancer Cell Line HGC-27
Authors: Silva Gabriel , Teixeira Lima Felipe , Seba Viviane , Mendes Lourenço Ana , Lucas Thaise , De Andrade Bianca , Torrezan Guilherme , Polaquini Carlos , Garcia Marcelo , Couto Lucélio , Bestetti Reinaldo , De Castro França Suzelei , Fachin Ana , Regasini Luis , Marins Mozart
Published: January 2018

Gastric cancer is one of the most frequent malignant tumors in the world. The majority of patients are diagnosed with metastatic gastric cancer, which has a low survival rate. These data reinforce the importance of studying the anticancer activity of new molecules with the potential to suppress gastric cancer metastasis. Curcumin is a well-studied compound that has demonstrated anti-metastatic effects. Here we investigated if CH-5, a curcumin derivative compound, has anti-metastatic properties in the human gastric cancer cell line HGC-27. Firstly, we found that CH-5 decreased viability and induced apoptosis in HGC-27 cells in a dose-dependent manner. Additionally, CH-5 suppressed the migration and invasion of HGC-27 cells by downregulating the expression and collagenase activity of matrix metalloproteinase 2 in a dose-dependent manner. In conclusion, CH-5 showed anticancer activities, including the induction of apoptosis, and the suppression of migration and invasion in HGC-27 cells, suggesting that CH-5 can be a lead molecule for the development of anti-metastatic drugs for gastric cancer therapy.
2-(2-Phenylethyl)-4H-chromen-4-one Derivatives from the Resinous Wood of Aquilaria sinensis with Anti-Inflammatory Effects in LPS-Induced Macrophages
Authors: Wang Sin-Ling , Tsai Yun-Chen , Fu Shu-Ling , Cheng Ming-Jen , Chung Mei-Ing , Chen Jih-Jung
Published: January 2018

The resinous wood of Aquilaria sinensis, known as agarwood (Chen Xiang in Chinese), is traditionally used for the treatment of abdominal pain, vomiting, circulatory disorders, and dyspnea. Four new 2-(2-phenylethyl)-4H-chromen-4-one derivatives, namely 7-methoxy-2-[2-(4′-hydroxy-phenyl)ethyl]chromone (1), 7-hydroxy-2-[2-(4′-methoxyphenyl)ethyl]chromone (2), 5,6-dihydroxy- 2-[2-(3′-hydroxy-4′-methoxyphenyl)ethyl]chromone (3), and 6-hydroxy-5-methoxy-2-(2-phenyl-ethyl)chromone (4), have been isolated from the resinous wood of A. sinensis, together with nine known compounds. The structures of these compounds were determined through spectroscopic and MS analyses. Among the isolated compounds, neopetasan, 7-methoxy-2-(2-phenylethyl)-chromone, 6,7-dimethoxy-2-(2-phenylethyl)chromone, and 6,7-dimethoxy-2-[2-(4′-methoxy-phenyl)ethyl]chromone inhibited NF-κB activation in LPS-stimulated RAW 264.7 macrophages with relative luciferase activity values of 0.55 ± 0.09, 0.54 ± 0.03, 0.31 ± 0.05, and 0.38 ± 0.14, respectively, versus that of vehicle control (1.03 ± 0.02). In addition, 5,6-dihydroxy-2-[2-(3′-hydroxy-4′-methoxyphenyl)ethyl]chromone, 7-methoxy-2-(2-phenylethyl)chromone, 7-dimethoxy-2-(2-phenylethyl)chromone, and 6,7-dimethoxy-2-[2-(4′-methoxyphenyl)ethyl]chromone could suppress LPS-induced NO production in RAW 264.7 cells and did not induce cytotoxicity against RAW 264.7 cells after 24-h treatment.
Heavily Boron-Doped Silicon Layer for the Fabrication of Nanoscale Thermoelectric Devices
Authors: Ma Zhe , Liu Yang , Deng Lingxiao , Zhang Mingliang , Zhang Shuyuan , Ma Jing , Song Peishuai , Liu Qing , Ji An , Yang Fuhua , Wang Xiaodong
Published: January 2018

Heavily boron-doped silicon layers and boron etch-stop techniques have been widely used in the fabrication of microelectromechanical systems (MEMS). This paper provides an introduction to the fabrication process of nanoscale silicon thermoelectric devices. Low-dimensional structures such as silicon nanowire (SiNW) have been considered as a promising alternative for thermoelectric applications in order to achieve a higher thermoelectric figure of merit (ZT) than bulk silicon. Here, heavily boron-doped silicon layers and boron etch-stop processes for the fabrication of suspended SiNWs will be discussed in detail, including boron diffusion, electron beam lithography, inductively coupled plasma (ICP) etching and tetramethylammonium hydroxide (TMAH) etch-stop processes. A 7 μm long nanowire structure with a height of 280 nm and a width of 55 nm was achieved, indicating that the proposed technique is useful for nanoscale fabrication. Furthermore, a SiNW thermoelectric device has also been demonstrated, and its performance shows an obvious reduction in thermal conductivity.
Total and Free Sugar Content of Pre-Packaged Foods and Non-Alcoholic Beverages in Slovenia
Authors: Zupanič Nina , Miklavec Krista , Kušar Anita , Žmitek Katja , Fidler Mis Nataša , Pravst Igor
Published: January 2018

Scientific evidence of the association between free sugar consumption and several adverse health effects has led many public health institutions to take measures to limit the intake of added or free sugar. Monitoring the efficiency of such policies and the amount of free sugar consumed requires precise knowledge of free sugar content in different food products. To meet this need, our cross-sectional study aimed at assessing free sugar content for 10,674 pre-packaged food items available from major Slovenian food stores during data collection in 2015. Together, 52.6% of all analyzed products contained free sugar, which accounted for an average of 57.5% of the total sugar content. Food categories with the highest median free sugar content were: honey and syrups (78.0 g/100 g), jellies (62.9 g/100 g), chocolate and sweets (44.6 g/100 g), jam and spreads (35.9 g/100 g), and cereal bars (23.8 g/100 g). Using year-round sales data provided by the retailers, the data showed that chocolate, sweets, and soft drinks alone accounted for more than 50% of all free sugar sold on the Slovenian market. The results of this study can be used to prepare more targeted interventions and efficient dietary recommendations.
Validation of the Brazilian Healthy Eating Index-Revised Using Biomarkers in Children and Adolescents
Authors: Toffano Roseli , Hillesheim Elaine , Mathias Mariana , Coelho-Landell Carolina , Salomão Roberta , Almada Maria , Camarneiro Joyce , Barros Tamiris , Camelo-Junior José , Rezzi Serge , Goulet Laurence , Giner Maria , Silva Laeticia , Martin Francois-Pierre , Montoliu Ivan , Moco Sofia , Collino Sebastiano , Kaput Jim , Monteiro Jacqueline
Published: January 2018

The Brazilian Healthy Eating Index-Revised (BHEI-R) can be used to determine overall dietary patterns. We assessed the BHEI-R scores in children and adolescents, aged from 9 to 13 years old, and associated its component scores with biomarkers of health and dietary exposure. Three 24-h recalls were used to generate BHEI-R. Biomarkers were analyzed in plasma and red blood cells. Correlation tests, agreement, and covariance analyses were used to associate BHEI-R components with biomarkers. Data from 167 subjects were used. The strongest correlations were between fruits, vegetables and legumes with omega-6 and omega-3 fatty acids, and β-carotene intakes. Milk and dairy correlated with plasma retinol and pyridoxine. All components rich in vegetable and animal protein sources correlated with plasma creatine. Total BHEI-R scores were positively associated with intakes of omega-6, omega-3, fiber and vitamin C, and inversely associated with energy and saturated fat intakes of individuals. Plasma β-carotene and riboflavin biomarkers were positively associated with total BHEI-R. An inadequate food consumption pattern was captured by both biomarkers of health and dietary exposure. BHEI-R was validated for the above dietary components and can be associated with metabolomics and nutritional epidemiological data in future pediatric studies.
The Influence of the Morphology and Mechanical Properties of Polymer Inclusion Membranes (PIMs) on Zinc Ion Separation from Aqueous Solutions
Authors: Witt Katarzyna , Radzyminska-Lenarcik Elzbieta , Kosciuszko Artur , Gierszewska Magdalena , Ziuziakowski Kamil
Published: January 2018

The transport of Zn(II) ions across polymer inclusion membranes (PIMs) with acetylacetone (ACAC) or di(2-ethylhexyl)phosphoric acid (D2EHPA) as carriers was studied. Polymeric membranes consisting of polyvinylchloride (PVC) as the support, bis(2-ethylhexyl)adipate (DAO) as plasticizer, and ACAC or D2EHPA as ion carriers were investigated. The highest recovery factors for Zn(II) ions were observed in the case of a membrane containing 20% acac (99.6%) and 60% D2EHPA (56.3%). The prepared PIMs were examined using atomic force microscopy (AFM) techniques. Their mechanical properties were also determined. The influence of membrane morphology and mechanical properties on the zinc transport process was discussed.
Evaluation of Optimized Tube-Gel Methods of Sample Preparation for Large-Scale Plant Proteomics
Authors: Balliau Thierry , Blein-Nicolas Mélisande , Zivy Michel
Published: January 2018

The so-called tube-gel method is a sample preparation protocol allowing for management of SDS for protein solubilization through in-gel protein trapping. Because of its simplicity, we assumed that once miniaturized, this method could become a standard for large scale experiments. We evaluated the performances of two variants of the miniaturized version of the tube-gel method based on different solubilization buffers (Tris-SDS or urea-SDS). To this end, we compared them to two other digestion methods: (i) liquid digestion after protein solubilization in the absence of SDS (liquid method) and (ii) filter-aided sample preparation (FASP). As large-scale experiments may require long term gel storage, we also examined to which extent gel aging affected the results of the proteomics analysis. We showed that both tube-gel and FASP methods extracted membrane proteins better than the liquid method, while the latter allowed the identification and quantification of a greater number of proteins. All methods were equivalent regarding quantitative stability. However, important differences were observed regarding post-translational modifications. In particular, methionine oxidation was higher with the tube-gel method than with the other methods. Based on these results, and considering time, simplicity, and cost aspects, we conclude that the miniaturized tube-gel method is suitable for sample preparation in the context of large-scale experiments.
High-Accuracy Positioning in Urban Environments Using Single-Frequency Multi-GNSS RTK/MEMS-IMU Integration
Authors: Li Tuan , Zhang Hongping , Gao Zhouzheng , Chen Qijin , Niu Xiaoji
Published: January 2018

The integration of Global Positioning System (GPS) real-time kinematics (RTK) and an inertial navigation system (INS) has been widely used in many applications, such as mobile mapping and autonomous vehicle control. Such applications require high-accuracy position information. However, continuous and reliable high-accuracy positioning is still challenging for GPS/INS integration in urban environments because of the limited satellite visibility, increasing multipath, and frequent signal blockages. Recently, with the rapid deployment of multi-constellation Global Navigation Satellite System (multi-GNSS) and the great advances in low-cost micro-electro-mechanical-system (MEMS) inertial measurement units (IMUs), it is expected that the positioning performance could be improved significantly. In this contribution, the tightly-coupled single-frequency multi-GNSS RTK/MEMS-IMU integration is developed to provide precise and continuous positioning solutions in urban environments. The innovation-based outlier-resistant ambiguity resolution (AR) and Kalman filtering strategy are proposed specifically for the integrated system to resist the measurement outliers or poor-quality observations. A field vehicular experiment was conducted in Wuhan City to evaluate the performance of the proposed algorithm. Results indicate that it is feasible for the proposed algorithm to obtain high-accuracy positioning solutions in the presence of measurement outliers. Moreover, the tightly-coupled single-frequency multi-GNSS RTK/MEMS-IMU integration even outperforms the dual-frequency multi-GNSS RTK in terms of AR and positioning performance for short baselines in urban environments.
Spectral Properties of Coniferous Forests: A Review of In Situ and Laboratory Measurements
Authors: Rautiainen Miina , Lukeš Petr , Homolová Lucie , Hovi Aarne , Pisek Jan , Mõttus Matti
Published: January 2018

Coniferous species are present in almost all major vegetation biomes on Earth, though they are the most abundant in the northern hemisphere, where they form the northern tree and forest lines close to the Arctic Circle. Monitoring coniferous forests with satellite and airborne remote sensing is active, due to the forests’ great ecological and economic importance. We review the current understanding of spectral behavior of different components forming coniferous forests. We look at the spatial, directional, and seasonal variations in needle, shoot, woody element, and understory spectra in coniferous forests, based on measurements. Through selected case studies, we also demonstrate how coniferous canopy spectra vary at different spatial scales, and in different viewing angles and seasons. Finally, we provide a synthesis of gaps in the current knowledge on spectra of elements forming coniferous forests that could also serve as a recommendation for planning scientific efforts in the future.
Theoretical and Experimental Studies on Inclusion Complexes of Pinostrobin and β-Cyclodextrins
Authors: Kicuntod Jintawee , Sangpheak Kanyani , Mueller Monika , Wolschann Peter , Viernstein Helmut , Yanaka Saeko , Kato Koichi , Chavasiri Warinthorn , Pongsawasdi Piamsook , Kungwan Nawee , Rungrotmongkol Thanyada
Published: January 2018

Pinostrobin (PNS) belongs to the flavanone subclass of flavonoids which shows several biological activities such as anti-inflammatory, anti-cancerogenic, anti-viral and anti-oxidative effects. Similar to other flavonoids, PNS has a quite low water solubility. The purpose of this work is to improve the solubility and the biological activities of PNS by forming inclusion complexes with β-cyclodextrin (βCD) and its derivatives, heptakis-(2,6-di-O-methyl)-β-cyclodextrin (2,6-DMβCD) and (2-hydroxypropyl)-β-cyclodextrin (HPβCD). The AL-type diagram of the phase solubility studies of PNS exhibited the formed inclusion complexes with the 1:1 molar ratio. Inclusion complexes were prepared by the freeze-drying method and were characterized by differential scanning calorimetry (DSC). Two-dimensional nuclear magnetic resonance (2D-NMR) and steered molecular dynamics (SMD) simulation revealed two different binding modes of PNS, i.e., its phenyl- (P-PNS) and chromone- (C-PNS) rings preferably inserted into the cavity of βCD derivatives whilst only one orientation of PNS, where the C-PNS ring is inside the cavity, was detected in the case of the parental βCD. All PNS/βCDs complexes had a higher dissolution rate than free PNS. Both PNS and its complexes significantly exerted a lowering effect on the IL-6 secretion in LPS-stimulated macrophages and showed a moderate cytotoxic effect against MCF-7 and HeLa cancer cell lines in vitro.
Comparing the Applicability of Commonly Used Hydrological Ecosystem Services Models for Integrated Decision-Support
Authors: Lüke Anna , Hack Jochen
Published: January 2018

Different simulation models are used in science and practice in order to incorporate hydrological ecosystem services in decision-making processes. This contribution compares three simulation models, the Soil and Water Assessment Tool, a traditional hydrological model and two ecosystem services models, the Integrated Valuation of Ecosystem Services and Trade-offs model and the Resource Investment Optimization System model. The three models are compared on a theoretical and conceptual basis as well in a comparative case study application. The application of the models to a study area in Nicaragua reveals that a practical benefit to apply these models for different questions in decision-making generally exists. However, modelling of hydrological ecosystem services is associated with a high application effort and requires input data that may not always be available. The degree of detail in temporal and spatial variability in ecosystem service provision is higher when using the Soil and Water Assessment Tool compared to the two ecosystem service models. In contrast, the ecosystem service models have lower requirements on input data and process knowledge. A relationship between service provision and beneficiaries is readily produced and can be visualized as a model output. The visualization is especially useful for a practical decision-making context.
Exploring the Strengths and Limits of Strong and Weak Sustainability Indicators: A Case Study of the Assessment of China’s Megacities with EF and GPI
Authors: Huang Lu
Published: January 2018

The perspective of strong/weak sustainability has a great impact on sustainability assessment. In this study, two most widely used indices, Ecological Footprint (EF) and Genuine Progress Indicator (GPI) for strong and weak sustainability assessment, were employed to evaluate the sustainability of China’s ten megacities between 1978 and 2015. The results showed that the ecological footprint had been enlarged in the past twenty years; while the genuine economic welfare started to increase since 2005. The cities of Xi’an, Chengdu, Chongqing, and Shanghai met the threshold of below 2.5 global hectares for EF/capita, and over 3000 dollars/capita (in 2010 US$) for GPI/capita. By analyzing and comparing the characteristics, the processes and results, and the complementary features of evaluation methods of EF and GPI, the research suggested that: (1) Strong and weak sustainability indicators, with their own pros/cons in sustainability assessment, should be used carefully; (2) Weak sustainability indicators could be analyzed from the perspective of strong sustainability; (3) Strong sustainability indicators need to be developed urgently. The results in this study could guide the selection of sustainability indicators, and help interpret the results of sustainability assessment.
Factors Affecting Online Impulse Buying: Evidence from Chinese Social Commerce Environment
Authors: Akram Umair , Hui Peng , Khan Muhammad , Yan Chen , Akram Zubair
Published: January 2018

First, the purpose of this study is to examine the impact of situational variables, scarcity and serendipity, on online impulse buying (OIB) in Chinese social commerce (SC) environment. Second, the study further assesses the moderating role of five dimensions of hedonic shopping value. Data were gathered from 671 online shoppers who come from two metropolitan cities of China, Beijing, and Shanghai. Structure equation modeling utilized was generated by AMOS 23 version to test the study hypotheses. The results confirm that situational factors positively influence the online impulse buying among Chinese online shoppers in SC environment. Four dimensions of hedonic shopping value (social shopping, relaxation shopping, adventure shopping and idea shopping) positively moderate the relationship between serendipity and OIB; value shopping is insignificant with moderation effect. The finding is helpful to the online retailers and SC web developers by recommending them to take the scarcity and serendipity in their consideration. These factors have the potential to motivate the consumers to initiate the hedonic shopping aptitude to urge to buy impulsively. Unlike the previous work which remained unsuccessful in incorporating all factors into one study, this study has incorporated irrational and unplanned consumption along with rational and planned one in the same research.
Effective Life Cycle Management in SMEs: Use of a Sector-Based Approach to Overcome Barriers
Authors: Seidel-Sterzik Helene , McLaren Sarah , Garnevska Elena
Published: January 2018

One approach to incorporate sustainability in organisations is the implementation of life cycle management (LCM). LCM involves sharing responsibility for addressing environmental impacts across the entire supply chain of products and services, extending from raw material extraction to end-of-life of the product. The New Zealand primary sector relies heavily on natural resources and provides about 70% of the country’s export revenue. Most companies in primary industry sectors in New Zealand are small and medium-sized enterprises (SMEs). Successful sector-wide uptake of LCM can potentially facilitate effective measurement and management of environmental impacts caused by this sector. The aim of this research was to identify the barriers and enablers to successful LCM uptake by New Zealand primary sector SMEs within a sector-based context. An extensive review of the literature was undertaken in the areas of change management for SMEs and supply chain management. The main factors influencing successful LCM uptake include owner/manager influence, environmental culture, resource availability, future orientation, knowledge of environmental issues, market requirements, geographical separation of production and consumption, awareness of own environmental issues and communication/information sharing. This paper forms the basis for future research and development of tools for the effective implementation of sector based approaches to LCM in the primary industry. The results of this research include a capability maturity model and the development of a cloud based platform for collaboration and communication around LCM.
Optimizing the Targeting of Mouse Parvovirus 1 to Murine Melanoma Selects for Recombinant Genomes and Novel Mutations in the Viral Capsid Gene
Authors: Marr Matthew , D’Abramo Anthony , Pittman Nikea , Agbandje-McKenna Mavis , Cotmore Susan , Tattersall Peter
Published: January 2018

Combining virus-enhanced immunogenicity with direct delivery of immunomodulatory molecules would represent a novel treatment modality for melanoma, and would require development of new viral vectors capable of targeting melanoma cells preferentially. Here we explore the use of rodent protoparvoviruses targeting cells of the murine melanoma model B16F10. An uncloned stock of mouse parvovirus 1 (MPV1) showed some efficacy, which was substantially enhanced following serial passage in the target cell. Molecular cloning of the genes of both starter and selected virus pools revealed considerable sequence diversity. Chimera analysis mapped the majority of the improved infectivity to the product of the major coat protein gene, VP2, in which linked blocks of amino acid changes and one or other of two apparently spontaneous mutations were selected. Intragenic chimeras showed that these represented separable components, both contributing to enhanced infection. Comparison of biochemical parameters of infection by clonal viruses indicated that the enhancement due to changes in VP2 operates after the virus has bound to the cell surface and penetrated into the cell. Construction of an in silico homology model for MPV1 allowed placement of these changes within the capsid shell, and revealed aspects of the capsid involved in infection initiation that had not been previously recognized.
Virus Infection Triggers MAVS Polymers of Distinct Molecular Weight
Authors: Zamorano Cuervo Natalia , Osseman Quentin , Grandvaux Nathalie
Published: January 2018

The mitochondrial antiviral signaling (MAVS) adaptor protein is a central signaling hub required for cells to mount an antiviral response following virus sensing by retinoic acid-inducible gene I (RIG-I)-like receptors. MAVS localizes in the membrane of mitochondria and peroxisomes and in mitochondrial-associated endoplasmic reticulum membranes. Structural and functional studies have revealed that MAVS activity relies on the formation of functional high molecular weight prion-like aggregates. The formation of protein aggregates typically relies on a dynamic transition between oligomerization and aggregation states. The existence of intermediate state(s) of MAVS polymers, other than aggregates, has not yet been documented. Here, we used a combination of non-reducing SDS-PAGE and semi-denaturing detergent agarose gel electrophoresis (SDD-AGE) to resolve whole cell extract preparations to distinguish MAVS polymerization states. While SDD-AGE analysis of whole cell extracts revealed the formation of previously described high molecular weight prion-like aggregates upon constitutively active RIG-I ectopic expression and virus infection, non-reducing SDS-PAGE allowed us to demonstrate the induction of lower molecular weight oligomers. Cleavage of MAVS using the NS3/4A protease revealed that anchoring to intracellular membranes is required for the appropriate polymerization into active high molecular weight aggregates. Altogether, our data suggest that RIG-I-dependent MAVS activation involves the coexistence of MAVS polymers with distinct molecular weights.
Consumption of Free Chlorine in an Aqueduct Scheme with Low Protection: Case Study of the New Aqueduct Simbrivio-Castelli (NASC), Italy
Authors: Torretta Vincenzo , Tolkou Athanasia , Katsoyiannis Ioannis , Katsoyiannis Athanasios , Trulli Ettore , Magaril Elena , Rada Elena
Published: January 2018

The safety of high quality drinking water supply relies on the quantities to be delivered, on the complexity of the water supply systems, and on the widespread phenomena of the contamination of water bodies. These parameters indicate the need for the development of an application that will allow the quick acquisition of data on strategic management. This is requires both the analysis of factors related to the hydraulic operation of the plants and the characteristics of water quality. The present paper aims to evaluate the use of models that predict data for water quality in a distribution system. The assessment is made in order to consider the use of the model as a support tool for the management system of a supply network and to optimize the quality of the provided service. The improvement of the control system related to the operations of disinfection, in particular, in the case of long pipelines, is absolutely mandatory in order to ensure the safety of public health and respect for the environment at high levels.
Hydrologic Regime Changes in a High-Latitude Glacierized Watershed under Future Climate Conditions
Authors: Valentin Melissa , Hogue Terri , Hay Lauren
Published: January 2018

A calibrated conceptual glacio-hydrological monthly water balance model (MWBMglacier) was used to evaluate future changes in water partitioning in a high-latitude glacierized watershed in Southcentral Alaska under future climate conditions. The MWBMglacier was previously calibrated and evaluated against streamflow measurements, literature values of glacier mass balance change, and satellite-based observations of snow covered area, evapotranspiration, and total water storage. Output from five global climate models representing two future climate scenarios (RCP 4.5 and RCP 8.5) was used with the previously calibrated parameters to drive the MWBMglacier at 2 km spatial resolution. Relative to the historical period 1949–2009, precipitation will increase and air temperature in the mountains will be above freezing for an additional two months per year by mid-century which significantly impacts snow/rain partitioning and the generation of meltwater from snow and glaciers. Analysis of the period 1949–2099 reveals that numerous hydrologic regime shifts already occurred or are projected to occur in the study area including glacier accumulation area, snow covered area, and forest vulnerability. By the end of the century, Copper River discharge is projected to increase by 48%, driven by 21% more precipitation and 53% more glacial melt water (RCP 8.5) relative to the historical period (1949–2009).
Alternatives to the face-to-face consultation in general practice: focused ethnographic case study
Authors: Atherton Helen , Brant Heather , Ziebland Sue , Bikker Annemieke , Campbell John , Gibson Andy , McKinstry Brian , Porqueddu Tania , Salisbury Chris
Published: January 2018

Background

NHS policy encourages general practices to introduce alternatives to the face-to-face consultation, such as telephone, email, e-consultation systems, or internet video. Most have been slow to adopt these, citing concerns about workload. This project builds on previous research by focusing on the experiences of patients and practitioners who have used one or more of these alternatives.

Aim

To understand how, under what conditions, for which patients, and in what ways, alternatives to face-to-face consultations present benefits and challenges to patients and practitioners in general practice.

Design and setting

Focused ethnographic case studies took place in eight UK general practices between June 2015 and March 2016.

Method

Non-participant observation, informal conversations with staff, and semi-structured interviews with staff and patients were conducted. Practice documents and protocols were reviewed. Data were analysed through charting and the ‘one sheet of paper’ mind-map method to identify the line of argument in each thematic report.

Results

Case study practices had different rationales for offering alternatives to the face-to-face consultation. Beliefs varied about which patients and health issues were suitable. Co-workers were often unaware of each other’s practice; for example, practice policies for use of e-consultations systems with patients were not known about or followed. Patients reported benefits including convenience and access. Staff and some patients regarded the face-to-face consultation as the ideal.

Conclusion

Experience of implementing alternatives to the face-to-face consultation suggests that changes in patient access and staff workload may be both modest and gradual. Practices planning to implement them should consider carefully their reasons for doing so and involve the whole practice team.
Recent advances on organic blue thermally activated delayed fluorescence (TADF) emitters for organic light-emitting diodes (OLEDs)
Authors: Bui Thanh-Tuân , Goubard Fabrice , Ibrahim-Ouali Malika , Gigmes Didier , Dumur Frédéric
Published: January 2018

The design of highly emissive and stable blue emitters for organic light emitting diodes (OLEDs) is still a challenge, justifying the intense research activity of the scientific community in this field. Recently, a great deal of interest has been devoted to the elaboration of emitters exhibiting a thermally activated delayed fluorescence (TADF). By a specific molecular design consisting into a minimal overlap between the highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO) due to a spatial separation of the electron-donating and the electron-releasing parts, luminescent materials exhibiting small S1–T1 energy splitting could be obtained, enabling to thermally upconvert the electrons from the triplet to the singlet excited states by reverse intersystem crossing (RISC). By harvesting both singlet and triplet excitons for light emission, OLEDs competing and sometimes overcoming the performance of phosphorescence-based OLEDs could be fabricated, justifying the interest for this new family of materials massively popularized by Chihaya Adachi since 2012. In this review, we proposed to focus on the recent advances in the molecular design of blue TADF emitters for OLEDs during the last few years.
Identifying Exoplanets with Deep Learning: A Five-planet Resonant Chain around Kepler-80 and an Eighth Planet around Kepler-90
Authors: Shallue Christopher J. , Vanderburg Andrew
Published: January 2018

NASA’sKepler Space Telescopewas designed to determine the frequency of Earth-sized planets orbiting Sun-like stars, but these planets are on the very edge of the mission’s detection sensitivity. Accurately determining the occurrence rate of these planets will require automatically and accurately assessing the likelihood that individual candidates are indeed planets, even at low signal-to-noise ratios. We present a method for classifying potential planet signals using deep learning, a class of machine learning algorithms that have recently become state-of-the-art in a wide variety of tasks. We train a deep convolutional neural network to predict whether a given signal is a transiting exoplanet or a false positive caused by astrophysical or instrumental phenomena. Our model is highly effective at ranking individual candidates by the likelihood that they are indeed planets: 98.8% of the time it ranks plausible planet signals higher than false-positive signals in our test set. We apply our model to a new set of candidate signals that we identified in a search of knownKeplermulti-planet systems. We statistically validate two new planets that are identified with high confidence by our model. One of these planets is part of a five-planet resonant chain around Kepler-80, with an orbital period closely matching the prediction by three-body Laplace relations. The other planet orbits Kepler-90, a star that was previously known to host seven transiting planets. Our discovery of an eighth planet brings Kepler-90 into a tie with our Sun as the star known to host the most planets.