bluuebunny/crossref_metadata_2025 huggingface dataset:
Oral administration of phytochemicals protects honey bees against cognitive and motor impairments induced by the insecticide fipronil
Authors: García Lina M. , Caicedo-Garzón Valentina , Riveros Andre J.
Published: March 2024

Pollution produced by exposure to pesticides is a major concern for food security because the negative impacts on pollinators. Fipronil, an insecticide broadly used around the globe has been associated with the ongoing decline of bees. With a characteristic neuroactive toxicodynamic, fipronil leads to cognitive and motor impairments at sublethal dosages. Despite of regional bans, multilevel strategies are necessary for the protection of pollinators. Recent evidence suggests that specific nutrients in the diets of bees may induce protection against insecticides. Here, we evaluated whether the administration of three phytochemicals, namely rutin, kaempferol and p-coumaric acid provide protection to the Africanized honey beeApis melliferaagainst oral administration of realistic dosages of fipronil. We tested the potential impairment produced by fipronil and the protection induced by the phytochemicals in learning, 24h memory, sucrose sensitivity and motor control. We found that the administration of fipronil induced a concentration-dependent impairment in learning and motor control, but not 24h memory or sucrose sensitivity across a 24h window. We also found that the administration of rutin, p-coumaric acid, kaempferol and the mixture was innocuous and generally offered protection against the impairments induced by fipronil. Overall, our results indicate that bees can be prophylactically protected against insecticides via nutrition, providing an alternative to the ongoing conflict between the use of insecticides and the decline of pollinators. As the studied phytochemicals are broadly present in nectar and pollen, our results suggest that the nutritional composition, and not only its production, should be considered when implementing strategies of conservation via gardens and co-cropping.
Natalizumab promotes anti-inflammatory and repair effects in multiple sclerosis
Authors: Lereim Ragnhild Reehorst , Nytrova Petra , Guldbrandsen Astrid , Havrdova Eva Kubala , Myhr Kjell-Morten , Barsnes Harald , Berven Frode S.
Published: March 2024

Background

Multiple sclerosis is an inflammatory and degenerative disease of the central nervous system leading to demyelination and axonal loss. Relapsing-remitting multiple sclerosis (RRMS) is commonly treated by anti-inflammatory drugs, where one of the most effective drugs to date is the monoclonal antibody natalizumab.

Methods

The cerebrospinal fluid (CSF) proteome was analyzed in 56 patients with RRMS before and after natalizumab treatment, using label-free mass spectrometry and a subset of the changed proteins were verified by parallel reaction monitoring in a new cohort of 20 patients, confirming the majority of observed changes.

Results

A total of 287 differentially abundant proteins were detected including (i) the decrease of proteins with roles in immunity, such as immunoglobulin heavy constant mu, chitinase-3-like protein 1 and chitotriosidase, (ii) an increase of proteins involved in metabolism, such as lactate dehydrogenase A and B and malate-dehydrogenase cytoplasmic, and (iii) an increase of proteins associated with the central nervous system, including lactadherin and amyloid precursor protein. Comparison with the CSF-PR database provided evidence that natalizumab counters protein changes commonly observed in RRMS. Furthermore, vitamin-D binding protein and apolipoprotein 1 and 2 were unchanged during treatment with natalizumab, implying that these may be involved in disease activity unaffected by natalizumab.

Conclusions

Our study revealed that some of the previously suggested biomarkers for MS were affected by the natalizumab treatment while others were not. Proteins not previously suggested as biomarkers were also found affected by the treatment. In sum, the results provide new information on how the natalizumab treatment impacts the CSF proteome of MS patients, and points towards processes affected by the treatment. These findings ought to be explored further to disclose potential novel disease mechanisms and predict treatment responses.
Effect of Ambrosia arborescens Mill. ethanolic extract on breast cancer induced in rats
Authors: Silva-Correa Carmen R. , Villarreal-La Torre Victor E. , Lozano-Ciudad Gladys E. , Gomez-Arce Ricardo M. , Castaneda-Carranza Julio A. , Dionicio-Rosado Deivy Y. , Cotrina-Leon Maria E. , Sagastegui-Guarniz William A. , Gamarra-Sanchez Cesar D. , Cruzado-Razco Jose L.
Published: March 2024

Background and Aim: Ambrosia arborescens Mill. (A. arborescens) is an aromatic plant used in traditional medicine as an anti-inflammatory, anti-tussive, anti-rheumatic, and anti-diarrheal agent. This study aimed to evaluate the effect of A. arborescens Mill. on a Rattus norvegicus var. albinus-induced breast cancer model.

Materials and Methods: We collected A. arborescens from the province of Julcan, La Libertad Region, Per, and prepared an ethanolic extract using pulverized leaves macerated in 96° ethanol for 72 h with magnetic stirring. In the evaluation of anticancer activity, four experimental groups with 10 female rats each were formed: Group I (Control-7,12-dimethylbenz[a] anthracene [DMBA]), which received DMBA (single dose) and physiological saline solution for 4 months, and Groups II, III, and IV, which received DMBA (single dose) and 200, 400, and 600 mg/kg/day of the ethanolic extract of A. arborescens, respectively, for 4 months.

Results: The DMBA control group presented histological characteristics of ductal carcinoma in situ with necrotic and inflammatory areas, whereas the A. arborescens extract group showed a decrease in tumor volume and recovery of the ductal duct.

Conclusion: Ethanol extract of A. arborescens leaves decreases tumor development in rats with induced breast cancer, and this effect is dose-dependent.

Keywords: 7,12-dimethylbenz[a]anthracene, Ambrosia arborescens, breast carcinoma in situ, cancer, rat.
A case of a missense DYNC1H1 mutation causing spinal muscular atrophy with lower limb predominance concurrent with germ cell tumor
Authors: Lee Myung Ah , Kim Myungshin , Lee Jung Hwan
Published: March 2024

We report a patient diagnosed with a germ-cell tumor presenting with spinal muscular atrophy with lower limb predominance (SMA-LED) caused by a DYNC1H1 genetic variant. His clinical and electrophysiologic phenotype was compatible with SMA-LED. We identified a heterozygous missense variant (c.1793G>T) of DYNC1H1. This report expands the clinical spectrum of DYNC1H1-related disorders, and reinforces the importance of DYNC1H1 in both central and peripheral neuronal functions. We suggest that germ-cell tumors should be considered as a possible phenotype of DYNC1H1-related disorders.
The amount of lower leg muscle and physical activity in patients with postural tachycardia syndrome
Authors: Lee Hyung , Kim Hyun Ah
Published: March 2024

Background: Resistance training for leg muscles is recommended for patients with postural tachycardia syndrome (POTS). However, no study has characterized the relationships between orthostatic symptoms, heart rate (HR) increase, and the mass of the lower leg muscle in patients with POTS. We sought to determine the relationships between the mass of the lower leg muscle, HR increase during the head-up tilt (HUT) test, and orthostatic symptoms in patients with POTS.Methods: We prospectively enrolled 42 patients with POTS who were older than 16 years. The muscle mass was estimated using bioelectrical impedance analysis. We used the International Physical Activity Questionnaire-Short Form to measure self-reported physical activity. All patients were asked to complete the Korean version of the Orthostatic Grading Scale (KOGS).Results: The HR increased during the HUT test by 38.7±7.88 beats/minutes. Both the HR increase during the HUT test and the total KOGS score were negatively correlated with the total metabolic equivalent of the task. The leg circumference and muscle mass were not correlated with the HR increase during the HUT test or the KOGS score.Conclusions: The leg circumference and muscle mass were not related to orthostatic symptoms in patients with POTS. Cardiac remodeling or blood volume increase may be responsible for improvement in POTS after physical activity.
Functional neuroanatomy of the vestibular cortex and vestibular stimulation methods for neuroimaging studies
Authors: Lee Seung-Keun , Lee Eek-Sung
Published: March 2024

The vestibular cortex is a distributed network of multisensory areas that plays a crucial role in balance, posture, and spatial orientation. The core region of the vestibular cortex is the parietoinsular vestibular cortex (PIVC), which is located at the junction between the posterior insula, parietal operculum, and retroinsular region. The PIVC is connected to other vestibular areas, the primary and secondary somatosensory cortices, and the premotor and posterior parietal cortices. It also sends projections to the vestibular nuclei in the brainstem. The PIVC is a multisensory region that integrates vestibular, visual, and somatosensory information to create a representation of head-in-space motion, which is used to control eye movements, posture, and balance. Other regions of the vestibular cortex include the primary somatosensory, posterior parietal, and frontal cortices. The primary somatosensory cortex is involved in processing information about touch and body position. The posterior parietal cortex is involved in integrating vestibular, visual, and somatosensory information to create a representation of spatial orientation. The frontal cortex is involved in controlling posture, and eye movements. The various methods used to stimulate the vestibular receptors in neuroimaging studies include caloric vestibular stimulation (CVS), galvanic vestibular stimulation (GVS), and auditory vestibular stimulation (AVS). CVS uses warm or cold water or air to stimulate the semicircular canals, GVS uses a weak electrical current to stimulate the vestibular nerve, and AVS uses high-intensity clicks or short tone bursts to stimulate the otolithic receptors.
A Noninferiority Trial Comparing 2 Days vs 5 Days of Terlipressin and Ceftriaxone in Terms of 5-Day Rebleeding for Patients With Acute Gastroesophageal Variceal Hemorrhage
Authors: Lo Gin-Ho , Yeh Jen-Hao , Tseng Cheng-Hao , Chen Tzu-Haw , Tai Chi-Ming , Wang Wen-Lun , Lin Hui-Chen
Published: March 2024

INTRODUCTION:

This trial was to shorten the duration of both vasoconstrictors and prophylactic antibiotics to only 2 days in the therapy of acute gastroesophageal variceal hemorrhage.

METHODS:

After successful endoscopic hemostasis of gastroesophageal variceal hemorrhage, eligible patients were randomized to receive terlipressin infusion 1 mg per 6 hours and ceftriaxone 1 g daily for 5 days (group A) or a similar regimen for 2 days (group B). Primary end points were very early rebleeding at 5 days, and secondary end points included 48-hour hemostasis, 42-day rebleeding, and hospitalization days.

RESULTS:

Group A comprised 48 patients, and group B comprised 52 patients. Both groups were comparable in the severity of liver disease. Forty-eight-hour initial hemostasis was 95.8% in group A and 100% in group B (P = 0.13). Very early rebleeding between 3 and 5 days occurred in 1 patient (2.1%) in group A and 2 patients (3.8%) in group B (P = 0.60). The difference was 1.8% and the 95% confidence interval was −1.31% to 2.08%, which demonstrated noninferiority. Forty-two-day rebleeding occurred in 5 patients (10.4%) in group A and 4 patients (7.7%) in group B (P = 0.63). The median hospitalization days were 8.5 ± 3.8 days in group A vs 5.6 ± 2.6 days in group B (P < 0.001).

DISCUSSION:

After successful endoscopic hemostasis of acute variceal bleeding, combination of 2-day terlipressin infusion and ceftriaxone therapy was not inferior to the 5-day regimen in terms of very early rebleeding, with the advantage of shortening hospitalization stay.
Sub-Micrometer Particles Remote Detection in Enceladus’ Plume Based on Cassini’s UV Spectrograph Data
Authors:   Research Network Łukasiewicz – Institute of Aviation, Kotlarz Jan , Kubiak Katarzyna , Zalewska Natalia ,   Space Research Center, Polish Academy of Sciences
Published: March 2024

Enceladus is the Saturnian satellite is known to have water vapor erupting from its south pole region called „Tiger Stripes”. Data collected by Cassini Ultraviolet Imaging Spectrograph during Enceladus transiting Saturn allow us to estimate water plume absorption from 1115.35–1912.50 Å and compare it to the Mie solutions of Maxwell equations for particles with a diameter in the range from 10 nm up to 2 µm. The best fit performed using Gradient Descent method indicates a presence of sub-micrometer particles of diameters: 120–180 nm and 240–320 nm consistent with Thermofilum sp., Thermoproteus sp., and Pyrobaculum sp. cell sizes present in hydrothermal vents on Earth.
An Automatic Testing Platform for Front-end of Websites and Web Applications in a SaaS Model – BrowserSpot
Authors:   ClickRay Sp. z o.o., Binek Szymon , Góral Jakub
Published: March 2024

The article presents a modern tool created in a SaaS model for automating tests of front-end for websites and network applications, BrowserSpot. The key elements and functions of the tool were presented, as well as the industry premises and issues that initiated the start of work on the solution. All eight stages of research and development project were discussed in detail, along with the results and key achievements of each of them. The tool was created in a SaaS model to maximize its accessibility for every type of user, and is available on the market as a product by ClickRay Sp. z o.o.
Diagnosing of Communication Between Process Stations of a Distributed Control System
Authors:   Politechnika Rzeszowska, Bednarek Marcin
Published: March 2024

The article describes selected fragments of the process diagnosing communication between process stations of a mini-DCS based on an AC 800F modular industrial controller. Conducted experiments provided information on the transmission method and location of process variable values in transferred messages. The information can be used to communicate the system’s stations with a gateway to expand communication capabilities in the future.
The Role and Importance of Digital Impedance Bridges in Contemporary Metrology
Authors:   Politechnika Śląska, Musioł Krzysztof , Kampik Marian , Ziółek Adam , Koszarny Maciej , Jursza Jolanta , Zawadzki Paweł ,   Główny Urząd Miar
Published: March 2024

The article presents current trends in impedance metrology of the highest accuracy. Attention was paid to digital non-quantum impedance bridges, which have been developed in many European National Metrology Institutes over the last decade. Particular attention in the article was devoted to the digital impedance bridge currently being developed at the Central Office of Measures in Warsaw. The conceptual diagram, system implementation and the progress of work related to the development of this bridge and its implementation in the near future into the national measurement system are presented as well.
Modeling of the Thermal Imaging Camera Signal for Optical-Flow Algorithms Evaluation
Authors:   Wojskowa Akademia Techniczna, Warszawa, Bieszczad Grzegorz , Sawicki Krzysztof , Ligienza Andrzej , Mścichowski Mariusz , Gogler Sławomir
Published: March 2024

The article presents a method of modeling the signal coming from a thermal imaging camera that allows to perform a comparative analysis of algorithms for determining the so-called optical-flow. The modeling method was created for the development of an inertial sensor determining the displacement of the vehicle based on the analysis of the image from a thermal imaging camera. As part of the development work, it was necessary to select the type of optical flow algorithm and optimize its parameters. The synthetic signal model allowed for quick prototyping and automatic optimization of its parameters. The article presents exemplary results of comparing the efficiency of SAD and Farnebäck algorithms in the context of application for thermal imaging.
Power Loss and Temperature Distribution in Coil of PFC Inductor with Air Gap for Multimode Operation
Authors:   Politechnika Łódzka, Kasikowski Rafał
Published: March 2024

Power converters inherently display non-linear load characteristics, resulting in a high level of mains harmonics, and hence the necessity of implementing Power Factor Correction (PFC). Active PFC circuitry typically comprises an inductor and a power switch to control and alter the input current so that it matches, in shape and phase, the input voltage. This modelling of the waveforms can be performed by means of distinct conduction modes of the PFC inductor. The digital controller implemented in the constructed and investigated boost-type PFC converter can be programmed to operate in discontinuous conduction mode (DCM), continuous conduction mode (CCM), or a combination of the two. The individual modes of operation, via distinct PFC inductor current waveforms, impact the overall efficiency of power conversion and, by extension, temperature distribution in the magnetic component. This paper investigates how the examined conduction modes bear on distinct power-loss mechanisms present in the PFC inductor, including high-frequency eddy-current-generating phenomena, and the fringing effect in particular. As demonstrated herein, the DCM operation, for the set output power level, exhibits exacerbated power dissipation in the winding of the inductor due to the somewhat increased RSM value of the current and the intensified fringing magnetic flux at an air gap. The latter assertion will undergo further, more quantitatively focused research. Finally, the construction of the coil was optimised to reduce power loss by diminishing eddy-current mechanisms.
Determinants of Unemployment Rate in Indonesia (2011-2021 Period)
Authors: Minah Naelul , Sekaringsih Riswanti Budi
Published: March 2024

This study aims to analyze the effect of economic growth, inflation, Human Development Index (HDI), Regional Minimum Wage (UMR) and investment on unemployment rates in Indonesia. The type of this study is quantitative research. Econometric analysis in this study is panel data analysis with a fixed effect model and a random effect model on the secondary data from the Indonesian Central Statistics Agency in 2011-2021 for 33 provinces. The results show that independent variables simultaneously have a significant effect on the unemployment rate in Indonesia during the period 2011-2022. Partially, the variables of Inflation, Human Development Index (HDI), Regional Minimum Wage (UMR) and investment have a significant and significant effect on the unemployment rate. At the same time, the Gross Regional Domestic Product (GRDP) variable does not affect Indonesia's unemployment rate during 2011-2022.
Socialization of Zakat and The Calculation Model for KAPMI Students (Indramayu Students and Students Family) in Yogyakarta
Authors: Puspitasari Arum , Melani Dian , Hanafi Febrian Rizky , Manzil Liizza Diana , Aini Millenia Ayu Nur , Romadon Muhammad , Firahmatillah Nafi’ah , Nawasanga Pipit , Irwanda Rahmadhany Putri , Ilahi Viliana Nanda , Khurniawanti Yeny Karina
Published: March 2024

This study aims to assess the extent of adolescent knowledge about zakat and its calculations. Zakat itself is the third pillar of Islam, therefore we need to know in detail the types of zakat, its calculations, and to whom it is distributed. Zakat is a part of the property that must be issued by Muslims to be given to 8 asnaf as stated in the Qur'an and Sunnah. In Indonesia, there is the National Amil Zakat Agency (BAZNAS) whose task is to collect and distribute zakat, infaq and shodaqoh. BAZNAS has also arranged all zakat calculations from zakat fitrah, shares, agriculture, professions and many more.Keywords: Zakat, Zakat Calculation, BAZNAS.
The Effect of Tax Awareness, Socialization Taxation, And Tax Sanctions Against Personal Taxpayer Compliance
Authors: Hikmah Nur
Published: March 2024

This study aims to determine the awareness of taxation, socialization of taxation, and tax sanctions affect the compliance of individual taxpayers. The data used are primary data obtained from questionnaires distributed to individual taxpayers. The results of the study indicate that tax awareness and tax sanctions have a positive effect on individual taxpayer compliance, while tax socialization does not affect individual taxpayers.
Improving Sharia Financial Literacy in Indonesia on A Digital Basis with the Introduction of the Sharia Non-Bank Finance Industry (Iknb) and Its Instruments
Authors: Difa Zahrah Zakiyah  , Shafa Athaya  , Alif Kahlil Gibran
Published: March 2024

The Islamic non-bank financial industry has experienced significant growth in recent years. In the context of an increasingly complex modern economy, this industry has played an important role in facilitating financial activities that comply with sharia principles. This journal aims to contribute to existing knowledge by presenting research papers, case studies, and theoretical discussions relating to the non-bank Islamic finance industry, while the purpose of the service is to increase public literacy towards Sharia IKNB. The method used in carrying out this community service activity is semi-structured and discussion, which includes material using short videos uploaded on social media with a discussion model in the form of asking questions and statements through the comment’s column. That way the results obtained from this service activity are the participant's literacy level towards IKNB and Sharia IKNB indicating that on average new participants understand the concept of Sharia IKNB.
Analisis Keakuratan Kualitas dan Kuantitas Sustainability Report Disclosure; Strategi Menarik Minat Investasi di Bank Syariah Indonesia
Authors: Maulana Nora
Published: March 2024

Advances in digital technology that penetrase so quickly create serious changes in various fields including the economy. Sustainability report disclosure is one of the crucial issues that is interesting and always hotly discussed by economic actors in the 5.0 era, including sharia economic actors. This research is important because the accuracy of the sustainability report disclosure is not only a form of compliance with sharia values but also as a trend of needs for stakeholders, and becomes an added value for companies including Bank Syariah Indonesia (BSI) in order to reach wider stakeholders and investors. Increasing the accuracy of the quality and quantity of the sustainability report disclosure can be a solution for BSI in developing its Islamic finance industry. As for the research objectives; First, knowing the effect of the accuracy of the quality and quantity of the sustainability report disclosure on financial performance; Second, knowing the impact of the quality and quantity of the sustainability report disclosure on investor interest in investing. This research is a type of field research with a mix method. The sample was determined through purposive sampling and obtained as many as 34 respondents. The research data used are primary data and secondary data, while the data collection method is done through questionnaires, interviews and documentation. The analysis technique was carried out by using multiple linear regression, t test, F test, and R-Square test. The results of the study show that the accuracy of the quality and quantity of the sustainability report’s disclosure, either partially or simultaneously, has a positive and significant effect on investment interest, as evidenced by the probability statistics obtained, namely 0.000 < 0.05. Both variables have an effect of 94,3% on interest in investing. From the results of the study, it is also known that the variable quality of sustainability report disclosure is the dominant variable that influences the level of investor interest in investing with the value obtained reaching 1.254085 on investors in the Valu Capital stock community in Banda Aceh.
Pengaruh Aspek-Aspek Demokrasi Indonesia Terhadap Pertumbuhan Ekonomi di Indonesia Periode 2016-2020
Authors: Sabardin  , Muhammad Ghafur Wibowo
Published: March 2024

This research aims to find out how aspects of democracy presented through civil liberties, political rights, and democratic institutions influence Indonesia's economic growth from 2016 to 2020. The Central Statistics Agency (BPS) provided the data and researchers used secondary data for this research from 2016 to 2022. The random effect model (REM) is the model selection test most commonly found in this research approach, which uses panel data regression analysis tools. It was found that variables related to democratic institutions positively and significantly influence economic growth. However, civil liberties and political rights did not affect Indonesia's economic growth from 2016 to 2020.
Determinasi Harga Perumahan di Indonesia dan Malaysia
Authors: Zamillaili Maulanidya , Qoyum Abdul
Published: March 2024

Rumah merupakan investasi pokok yang dimiliki oleh rumah tangga. Hal tersebut membuat risiko harga perumahan merupakan resiko paling dasar yang dihadapi oleh rumah tangga. Maka perubahan harga perumahan merupakan sesuatu yang penting bagi rumah tangga. Harga rumah pada umumnya dipengaruhi oleh faktor ekonomi fundamental negara bersangkutan serta dinamika penawaran dan permintaan pasar perumahan lokal. Penawaran dan permintaan rumah dipengaruhi oleh factor-faktor ekonomi pada negara bersangkutan. Maka penelitian ini mempunyai maksud untuk mengetahui bagaimana hubungan variabel ekonomi terhadap harga perumahan di Indonesia dan Malaysia. Variabel dependen dalam penelitian ini yaitu pertumbuhan harga perumahan. Sedangkan variabel independen yang digunakan yaitu suku bunga, pertumbuhan kredit, upah, inflasi, indeks saham, harga saham properti, dan PDB. Data yang digunakan dalam penelitian yaitu data pada tahun 2005-2019. Hasil penelitian menjelaskan bahwa secara parsial inflasi, upah, dan harga saham properti memiliki pengaruh yang positif dan signifikan terhadap harga perumahan. Sedangkan indeks saham berpengaruh negatif dan signifikan terhadap harga perumahan. Untuk variabel suku bunga, PDB, dan pertumbuhan kredit tidak memiliki pengaruh signifikan terhadap harga perumahan. Analisis secara simultan terhadap seluruh variabel menunjukkan bahwa seluruh variabel independen memiliki pengaruh signifikan terhadap harga perumahan
Tratamento de má oclusão de Classe II utilizando aparelhos autoligáveis passivos com prescrições variáveis, associados a elásticos intermaxilares de Classe II: relato de caso clínico
Authors: Villela Henrique Mascarenhas , Drago Paula
Published: March 2024

INTRODUÇÃO: As más oclusões de Classe II de Angle de natureza dentoalveolar ou esquelética moderada podem ser tratadas com extração de pré-molares, ancoragem extrabucal, protração mandibular, elásticos de Classe II e distalizadores intrabucais. Esse tipo de má oclusão pode ocorrer em diversos estágios da dentição humana. Na dentição mista, um dos estágios do desenvolvimento da oclusão, ocorrem muitas transformações, não só em relação às trocas dentárias, mas também no crescimento e desenvolvimento facial. Entre os diversos tipos de tratamentos interceptativos, o uso de aparelhos fixos autoligáveis passivos com prescrições variáveis, associados a arcos de NiTi termoativados, com molas de NiTi, é uma excelente opção para efetuar o alinhamento, nivelamento e ganho de espaço. Em casos selecionados, essa mecânica pode efetuar distalização, expansão, protrusão e reduzir a indicação de extrações seriadas ou expansão rápida de maxila. Esse recurso pode estar associado ao uso de elásticos de Classe II para efetuar correções das más oclusões de Classe II de Angle de natureza dentoalveolar ou esquelética moderada. OBJETIVO: O presente artigo mostra um caso clínico de Classe II total que utilizou como opção de tratamento corretivo, ao final da dentição mista, braquetes autoligáveis passivos com torques variáveis, para conseguir espaço para a erupção dos pré-molares e distalizar os molares superiores com auxílio de elásticos intermaxilares de Classe II. CONCLUSÃO: Essa estratégia de tratamento corretivo foi eficiente na obtenção de espaço para todos os pré-molares, finalizando a oclusão em Classe I de molares, pré-molares e caninos. Também pode-se observar uma boa relação final dos incisivos, com bom perfil facial.
Expansão ortopédica da maxila em adultos. Parte 1: resumo da avaliação pré-expansão
Authors: Romano Fábio Lourenço , Scombatti Sergio Luis , Marques Fernanda Vicioni , Gurgel Julio de Araújo
Published: March 2024

Introdução: A mordida cruzada posterior (MCP) e a deficiência transversal da maxila são más oclusões prevalentes na população, e podem ser corrigidas por meio de diferentes tratamentos, dependendo de suas características e do desenvolvimento esquelético do paciente. Objetivo: Discutir os principais métodos de expansão da maxila em adultos, com ênfase na avaliação pré-expansão. Métodos: Foram discutidos diagnósticos, características oclusais, maturação sutural, condições periodontais prévias, bem como os efeitos e as terapias decorrentes dessa avaliação inicial. Todos esses tópicos foram discutidos por meio da comparação entre as técnicas de expansão rápida do palato assistida por mini-parafuso (MARPE), expansão rápida do palato assistida cirurgicamente (SARPE) e expansão rápida do palato assistida cirurgicamente em três segmentos (TS-SARPE). Resultados: O diagnóstico prévio da relação oclusal transversal e a quantidade de expansão são essenciais para o sucesso do tratamento. Porém, devem ser consideradas principalmente as condições periodontais dos indivíduos, pois a maior parte dos resultados esperados da expansão é advinda de inclinações dos dentes para vestibular. Procedimentos adicionais incorporados às duas técnicas (SARPE e MARPE) mostram-se recursos encorajadores para aumentar a taxa de sucesso, reduzir os efeitos colaterais indesejáveis e aumentar a quantidade e a qualidade da abertura da sutura palatina mediana. Conclusão: Esse é o primeiro artigo de uma trilogia que abordará os aspectos mais relevantes relacionados à expansão ortopédica da maxila em adultos, usando diferentes técnicas.
Anotaciones sobre derecho constitucional comparado
Authors: Peribáñez Blasco Elena
Published: March 2024

Este es un texto cuyo único objetivo es el de proporcionar a las y los estudiantes de grado (y al público general) una herramienta que les permita introducirse sin dificultad en el conocimiento de las “formas políticas” en el Derecho Constitucional Comparado. Una aproximación a los principales modelos de organización y de gobierno de los Estados contemporáneos. Una obra que intenta romper con el abordaje íntegramente eurocentrista, que suele lo habitual en este tipo de materiales o programas al uso, en un deseo de comenzar a aportar otras visiones y enfoque de la estructuración del Estado.
Analisa Lapisan Termoklin Musiman Di Perairan Indonesia (Studi Kasus Selat Malaka)
Authors: Hendra Hendra , Pranowo Widodo Setiyo , Umam Choirul , Azhari Ferian , Agustinus Agustinus
Published: March 2024

The Malacca Strait is a strategic waterway for Indonesia as it serves as an international shipping route connecting East Asia with the Middle East and Europe. In addition, the Malacca Strait also has great potential for natural resources, such as oil and gas as well as fish and other marine products. This study aims to describe the Thermocline Layer in the Malacca Strait based on Marine Copernicus Data in 2020 with a depth of up to 1000 meters. The temperature data was visualized using ODV 5.5.2 software. The results of processing the Marine Copernicus Temperature Data in 2020 in the Malacca Strait with a depth of up to 1000 meters show that the thermocline boundary varies each season. In the western season, the thermocline boundary is at a depth between 11 meters to 131 meters, in the first transitional season, it is at a depth between 22 meters to 131 meters, in the eastern season, it is at a depth between 56 meters to 156 meters, and in the second transitional season, it is at a depth between 78 meters to 131 meters. Bagian Selat Malaka adalah perairan yang strategis bagi Indonesia karena menjadi jalur pelayaran internasional yang menghubungkan Asia Timur dengan Timur Tengah dan Eropa. Selain itu, Selat Malaka juga memiliki potensi sumber daya alam yang besar, seperti minyak dan gas bumi serta ikan dan hasil laut lainnya. Penelitian ini bertujuan untuk mengidentifikasi dan menganalisis Lapisan Termoklin di Perairan Selat Malaka berdasarkan Data Marine Copernicus tahun 2020 dengan kedalaman sampai 1000 meter. Data Temperatur diolah dan dianalisis menggunakan software ODV 5.5.2. Hasil pengolahan Data Temperatur Marine Copernicus tahun 2020 di Perairan Selat Malaka dengan kedalaman mencapai 1000 meter dengan batas termoklin setiap musim dimana pada Musim barat batas termoklin berada pada kedalaman antara 11 meter sampai dengan 131 meter, Musim Peralihan I batas termoklin berada pada kedalaman antara 22 meter sampai dengan 131 meter, Musim Timur batas termoklin berada peda kedalaman antara 56 meter sampai dengan 156 meter dan Musim Peralihan II batas termoklin berada pada kedalaman antara 78 meter sampai dengan 131 meter.
Language teacher professional curiosity: Understanding the drive for professional development
Authors: Mercer Sarah , Pawlak Mirosław
Published: March 2024

Teacher professional development (PD) has been shown to have numerous benefits, such as greater self-efficacy, higher motivation, and enhanced wellbeing (e.g., Kimura, 2014; Polin, 2023; Wang & Chen, 2022), and teaching additional languages is certainly no exception. However, the extent to which teachers are willing and able to engage in PD throughout their careers depends on many factors, some of which are related to the context in which they work, while others are reflective of their individual attributes such as attitudes, motivations, and personality. This paper focuses on the latter by reporting the findings of a study that examined language teacher professional curiosity (LTPC). The data were collected through semi-structured interviews from 6 Austrian and 6 Polish language teachers at different stages of their careers. Qualitative analysis allowed valuable insights into the nature of LTPC, curiosity-driven behaviors as well as factors influencing these behaviors. It also provided the basis for a tentative cyclic process model of LTPC in which interest and curiosity interact to produce a focus of curiosity, which is impacted by motivation, agency, autonomy, and social context, generating a drive for teacher behaviors in respect to their PD.
η-Ricci--Yamabe and *-η-Ricci--Yamabe solitons in Lorentzian para-Kenmotsu manifolds
Authors: Prasad Rajendra , Haseeb Abdul , Kumar Vinay
Published: March 2024

The main purpose of this paper is to study η-Ricci–Yamabe solitons (η-RYS) and

*

{*}

-η-Ricci–Yamabe solitons (

*

{*}

-η-RYS) in Lorentzian para-Kenmotsu n-manifolds (briefly,

(
LPK
)

n

{(\mathrm{LPK})_{n}}

). We study the curvature condition

R
.

S
=
0

{R.S=0}

and the cyclic parallel Ricci tensor in

(
LPK
)

n

{(\mathrm{LPK})_{n}}

admitting η-RYS. Furthermore, we study M-projectively flat and quasi-M-projectively flat Lorentzian para-Kenmotsu manifolds admitting

*

{*}

-η-RYS. Finally, we give two examples of Lorentzian para-Kenmotsu manifolds admitting η-RYS and

*

{*}

-η-RYS to verify some of our results.
Withaferin A alters the expression of microRNAs 146a-5p and 34a-5p and associated hub genes in MDA-MB-231 cells
Authors: Shuaib Mohd , Chaudhri Smriti , Kumar Shashank
Published: March 2024

Triple-negative breast cancer (TNBC) is a highly metastatic subtype of breast cancer. Due to the absence of obvious therapeutic targets, microRNAs (miRNAs) provide possible hope to treat TNBC. Withaferin A (WA), a steroidal lactone, possesses potential anticancer activity with lesser side effects. The present study identifies hub genes (CDKN3, TRAF6, CCND1, JAK1, MET, AXIN2, JAG1, VEGFA, BRCA1, E2F3, WNT1, CDK6, KRAS, MYB, MYCN, TGFβR2, NOTCH1, SIRT1, MYCN, NOTCH2, WNT3A) from the list of predicted targets of the differentially expressed miRNAs (DEMs) in WA-treated MDA-MB-231 cells using in silico protein–protein interaction network analysis. CCND1, CDK6, and TRAF6 hub genes were predicted as targets of miR-34a-5p and miR-146a-5p, respectively. The study found the lower expression of miR-34a-5p and miR-146a-5p in MDA-MB-231 cells, and further, it was observed that WA treatment effectively restored the lost expression of miR-34a-5p and miR-146a-5p in MDA-MB-231 cells. An anti-correlation expression pattern was found among the miR-34a-5p and miR-146a-5p and the respective target hub genes in WA-treated TNBC cells. In conclusion, WA might exert anti-cancer effect in TNBC cells by inducing miR-34a-5p and miR-146a-5p expressions and decreasing CCND1, CDK6, and TARF6 target hub genes in TNBC cells.
Antibacterial and dynamical behaviour of silicon nanoparticles influenced sustainable waste flax fibre-reinforced epoxy composite for biomedical application
Authors: Natrayan L. , Ameen Fuad , Chinta Neelima Devi , Teja Nalla Bhanu , Muthu G. , Kaliappan S. , Ali Saheb , Vadiveloo Ashiwin
Published: March 2024

This article explores the impact of nano-silica on the properties of woven flax fibre/epoxy composites. Using compression moulding, epoxy/flax/silica hybrid nanocomposites were produced. The nano-silica was dispersed in the epoxy matrix via ultrasonication at various weight ratios. A series of tests, including crack durability, dynamic mechanical analysis, and scanning electron microscopy, were conducted to evaluate the modified materials. Notably, a 3% nano-silica filler load resulted in a 54% and 57% improvement in initiation and transmission interfacial fracture toughness, respectively. Scanning electron microscope imaging confirmed that fibres pull out at the crack tip during initial debonding, accounting for the increased toughness. Dynamic mechanical analysis further revealed enhancements in mechanical properties. Moreover, the 3% nano-silica content led to less fibre pull-out, suggesting higher heat resistance than standard flax/epoxy composites. The material also demonstrated promising antimicrobial efficacy against gram-positive and gram-negative bacteria, offering a potential alternative to conventional antibiotics.
Eine kontrastive Untersuchung über das Raumerleben anhand von Berichten im chinesischen und deutschen Reisemagazin
Authors: Liang Shanshan , Zou Ziyuan
Published: March 2024

In der Humangeografie beschreiben das Ortsgefühl sowie das Raumgefühl die vergesellschafteten Beziehungen zwischen Menschen und Raum. Die beiden Gefühle können zusammen als Raumerleben bezeichnet werden. Wie das Raumerleben in konkreten Fällen zum Ausdruck kommt und inwiefern es mit bestimmten kulturellen Einflüssen präsentiert wird, sind für die interkulturelle Forschung interessante Fragestellungen. Das Raumerleben ist nämlich als kulturelles Erleben zu interpretieren. Somit zielt die vorliegende Untersuchung darauf ab, in Reiseberichten des deutschen Reisemagazins GEO SAISON und des chinesischen Reisemagazins TRENDS TRAVELER in Bezug auf die repräsentative Landschaft als „Ort“, räumliche Wahrnehmung und räumliche Wertvorstellung das jeweilige Raumerleben als kulturelles Erleben miteinander zu vergleichen und zu erforschen.
“I’ve just lived inside a tumble dryer”: a narrative of emotion labour, (de)motivation, and agency in the life of a language teacher
Authors: Banegas Darío Luis
Published: March 2024

Tensions between external sources of power and internal feeling rules in the workplace, i.e., emotion labour, can have a profound effect on professional dimensions. The purpose of this article is to report on a study that explored a secondary language teacher’s emotion labour and its influence on her professional (de)motivation and agency. Framed in narrative inquiry, this longitudinal study collected data through narrative interviews and drawings between February 2020 and March 2022. The participant was an EFL (English as foreign language) teacher who held teaching posts at three different state secondary schools and a private language centre in Argentina. During this period, the teacher grappled with emergency online teaching due to the Covid-19 pandemic and lengthy teacher strikes. Drawing on analysis of the short stories constructed from the narrative interviews, the tensions between external and internal feeling rules and their interplay with (de)motivation and agency are chronologically mapped out.
Realtime assessment of vascular occlusion and reperfusion in animal models of intraoperative imaging – a pilot study
Authors: Kandukuri Jayanth , Jain Aseem , Karmarkar Parag , Gadagkar Hrishikesh , Aberman Harold , Wang Qihong , Rege Abhishek
Published: March 2024

Objectives

Intraoperative monitoring of blood flow (BF) remains vital to guiding surgical decisions. Here, we report the use of SurgeON™ Blood Flow Monitor (BFM), a prototype system that attaches to surgical microscopes and implements laser speckle contrast imaging (LSCI) to noninvasively obtain and present vascular BF information in real-time within the microscope’s eyepiece.

Methods

The ability of SurgeON BFM to monitor BF status during reversible vascular occlusion procedures was investigated in two large animal models: occlusion of saphenous veins in six NZW rabbit hindlimbs and clipping of middle cerebral artery (MCA) branches in four Dorset sheep brain hemispheres. SurgeON BFM acquired, presented, and stored LSCI-based blood flow velocity index (BFVi) data and performed indocyanine green video angiography (ICG-VA) for corroboration.

Results

Stored BFVi data were analyzed for each phase: pre-occlusion (baseline), with the vessel occluded (occlusion), and after reversal of occlusion (re-perfusion). In saphenous veins, BFVi relative to baseline reduced to 5.2±3.7 % during occlusion and returned to 102.9±14.9 % during re-perfusion. Unlike ICG-VA, SurgeON BFM was able to monitor reduced BFVi and characterize re-perfusion robustly during five serial occlusion procedures conducted 2–5 min apart on the same vessel. Across four sheep MCA vessels, BFVi reduced to 18.6±7.7 % and returned to 120.1±27.8 % of baseline during occlusion and re-perfusion phases, respectively.

Conclusions

SurgeON BFM can noninvasively monitor vascular occlusion status and provide intuitive visualization of BF information in real-time to an operating surgeon. This technology may find application in vascular, plastic, and neurovascular surgery.
Boundary controllability for variable coefficients one-dimensional wave equation with interior degeneracy
Authors: Azzaoui Mohamed , Salhi Jawad , Tilioua Mouhcine
Published: March 2024

In this paper, we study boundary controllability for the linear extension problem of a wave equation with space-dependent coefficients and having an internal degeneracy. For this purpose, we mainly focus on the well-posedness and the boundary null controllability of a relaxed version of the original problem, namely, to some degenerate transmission problem. The key ingredient is to derive direct and inverse inequalities for the associated homogeneous degenerate adjoint problem. By these inequalities, we deduce that the transmission problem has a unique solution by transposition and this solution is null controllable. Moreover, we give an explicit formula of the controllability time.
Amitsur's theorem, semicentral idempotents, and additively idempotent semirings
Authors: Rachev Martin , Trendafilov Ivan
Published: March 2024

The article explores research findings akin to Amitsur’s theorem, asserting that any derivation within a matrix ring can be expressed as the sum of an inner derivation and a hereditary derivation. In most results related to rings and semirings, Birkenmeier’s semicentral idempotents play a crucial role. This article is intended for PhD students, postdocs, and researchers.
Perceived worsening of obsessive-compulsive disorder symptoms after childbirth in women and men: An understudied phenomenon
Authors: Ramirez Jennifer C. , Buissonnière-Ariza Valérie La , McIngvale Elizabeth , Rufino Katrina A. , Puryear Lucy J. , Treece Christina Annette , Schneider Sophie C. , Cepeda Sandra L. , Goodman Wayne K. , Storch Eric A.
Published: March 2024

The aim of this study was to examine worsening of OCD symptoms after childbirth in individuals seeking assessment or treatment of OCD. The postpartum period may make parents biologically and psychologically vulnerable to OCD symptoms. Participants included 222 parents with OCD who completed surveys through a self-help website. Most women and almost half of men with self-reported OCD reported an increase in OCD symptoms following childbirth. Retrospective report of perceived worsening of OCD symptoms after childbirth was associated with more aggressive obsessions for both men and women, in comparison to individuals whose OCD symptoms did not worsen around childbirth. Women whose OCD symptoms worsened after childbirth reported more impairment in social functioning than individuals whose symptoms did not worsen. These results highlight the need to develop a better understanding of aggressive obsessions in parents, and improve education about prevalence, content, assessment, and intervention for aggression-focused intrusive thoughts.
On the Trait Like Nature of Emotion Regulation Dynamics: Limited Evidence
Authors: Shryock Ian , Condon David M. , Weston Sara J.
Published: March 2024

Measuring the variable and flexible use of emotion regulation (ER) has been increasingly viewed as a more nuanced approach to understanding ER than only assessing mean-level strategy use. However, it is unclear to what extent ER variability and flexibility are trait-like individual differences that show longitudinal consistency and validity across time. In the current study, we use data from an experience sampling study that uses a burst design, wherein the same participants were tested twice across an interval of one year (NW1 = 396, NW2 = 175). We test the extent to which ER tendency, variability, flexibility, and responsivity are stable across time and show consistent relationships with outcome measures. Tendency and, to some extent, responsivity showed consistency across time; variability and flexibility did not. Further, the associations with outcomes were inconsistent across time for tendency and few consistent patterns of associations emerged for variability, flexibility, or responsivity. These findings suggest that these dynamic measures of emotion regulation may not be best conceptualized as stable within-person traits.
Eklezjologia Aleksego Chomiakowa
Authors: Paprocki Henryk
Published: March 2024

Alexei Khomiakov (1804–1860), poet, playwright, publicist, philosopher, inventor and a cavalry officer, played a decisive role in the development of European theology, overcoming scholastic categories. a special contribution in this process had his work „The Church is one” that – with its catechist character – departs from the understanding of the Church as an institution. It was written during the peak development of scholasticism in russia and marked the end of that method. It also influenced significantly the development of theology of other Christian Churches. The article is accompanied by a translation of Khomiakov’s work „The Church is one”.