bluuebunny/crossref_metadata_2025 huggingface dataset:
ПЯТЬ ЭТАПОВ РАЗВИТИЯ ФУТУРОЛОГИИ КАК НАУЧНОЙ ДИСЦИПЛИНЫ: ОТ ПРЕДЫСТОРИИ К СОВРЕМЕННОСТИ
Authors: Рочняк Елена Владимировна
Published: August 2022

Футурология в целом – обобщенное название совокупности концепций о будущем планеты, человечества, процессов и явлений на основе научных знаний и прогнозов. Футурологию часто понимают как «историю будущего» или, как предлагал еще О. Флетхейм, «философию будущего», которая будет альтернативой идеологиям. Актуальность исследования заключается в комплексном рассмотрении истории развития и трансформации футурологии как научной дисциплины. Цель: раскрыть и кратко охарактеризовать ключевые идеи, концепции и события основных этапов развития футурологии. Методы: анализ и обобщение научной литературы, проблемно сфокусированное сравнение теоретических концепций. Результаты: исследование показало, что в истории футурологии можно выделить пять основных этапов: предыстория (конец XIX – начало ХХ вв.), зарождение (середина 1940-х – середина 1960-х гг.), возникновение основных концепций и институтов (вторая половина 1960-х – начало 1990-х гг.), систематизация знаний (начало 1990-х – 2010-е гг.) и современный этап (последние 10–15 лет). Выявлены специфические черты, характерные для каждого из этапов, указаны концепции и идеи основных мыслителей и ученых, которые считаются классиками футурологии. Выводы: за историю развития научных исследований будущего было выработано достаточное количество идей и концепций, которые необходимо развивать и учитывать в процессе как теоретических размышлений о перспективах человечества, так и во время разработки и воплощения различных проектов совершенствования окружающей реальности. Основными проблемами современности, требующими решения на базе футурологии, можно считать следующие: неконтролируемое развитие технологий; дегуманизация всех сфер жизни и доминирование экономических интересов; глобализация как тотальная унификация. Эти и другие проблемы максимально актуализируют общефилософский, холистический, а не узкоотраслевой подход в современной футурологии
ТЕХНИЧЕСКАЯ ЭФФЕКТИВНОСТЬ РЕГИОНОВ КАК ИНСТРУМЕНТ ПОВЫШЕНИЯ КОНКУРЕНТОСПОСОБНОСТИ ТЕРРИТОРИЙ ЗА СЧЕТ СТРАТЕГИИ ТЕХНОЛОГИЧЕСКОГО АРБИТРАЖА (ИМИТАЦИИ)
Authors: Чистякова Наталья Олеговна , Михальчук Александр Александрович , Татарникова Валерия Владимировна , Акерман Екатерина Александровна , Изотова Анастасия Сергеевна
Published: August 2022

Статья посвящена проблематике повышения конкурентоспособности регионов за счет применения стратегии технологического арбитража на макрорегиональном уровне. В работе исследуются возможности применения стратегии имитации для регионов-последователей по степени эффективности использования ресурсов. Стратегии, основанные на парадигме технологического лидерства, можно рассматривать как более эффективные комбинации ресурсов, которые явно превосходят имеющиеся альтернативы и включают: концентрацию человеческого капитала; лидерство на рынках технологий; генерацию знаний и их реализацию. Эти стратегии развития подходят для мегаполисов, поскольку требуют интенсивного взаимодействия и институционального обеспечения для взаимодействия между различными акторами, такими как фирмы, университеты, исследовательские и инновационные центры и правительства. Кроме того, они являются магнитами для привлечения качественного человеческого капитала. Периферийные регионы считаются менее инновационными и, как правило, имеют меньше патентов и инвестиций в НИОКР, что приводит к сосредоточению внимания на процессах и догоняющих инновациях и, следовательно, к необходимости собственной стратегии развития. В статье разрабатывается и иллюстрируется методология, основанная на анализе среды функционирования и других методах, которые можно использовать для прояснения региональной стратегии. Исследуются различные типы региональных инноваций на основе лонгитюдного анализа регионов СФО РФ за десятилетний период. Этот подход позволил оценить эффективность использования базовых экономических ресурсов (труд-капитал) на региональном уровне, выделил модель развития регионов за счет инноваций либо технологического арбитража. В результате применения метода DEA и MPI были определены регионы − лидеры по эффективности использования разных типов ресурсов. Это позволило кластеризовать регионы по разному типу лидерства и выделить такие, которым рекомендована имитационная стратегия в зависимости от близости к технологическому фронтиру.
Humanitarian Evidence and Discourse Summary No.29
Authors: Kelly Luke
Published: August 2022

This is the 29th monthly Knowledge, Evidence and Learning for Development (K4D) Programme’s Humanitarian Evidence Summary (HUMES), signposting to the latest relevant evidence and discourse on humanitarian action to inform and support their response. It is the result of one day of work per month and is not intended to be a comprehensive summary of available evidence on humanitarian action but aims to make original documents easily accessible to decision-makers that, if relevant to them, they could refer to before making decisions.
The Effects of Differences such as Variety, Region and Plant Density on the Relationship between Grain Quality Criteria in Faba Bean
Authors: Zulkadir Gülay , İdikut Leyla , Çapar Yunus Emre
Published: August 2022

In this study, two varieties of faba beans were grown in two different locations at three different plant densities and their grain quality criteria were examined. As a result, the ash, oil, moisture, protein, starch and hundred grain weight (HGW) values of the faba beans varied between 3.44-3.76%, 1.16-1.70%, 10.63-11.58%, 25.71-31.15%, 37.86-44.75% and 97.53-157.50 g respectively. In correlation analysis, the highest interaction between moisture and oil; between protein and ash, oil and moisture; and between HGW and oil, moisture. In addition, it was determined that the significance level of the interaction among properties varies in terms of factors. PCA results, it was noted that each location formed separate groups. In general, all the features in Sanli-Urfa location were high and positive. In terms of varieties, the data of all properties except HGW were statistically the same, while the HGW value was high in Salkim variety. The distance row spacings significantly affected the starch and HGW properties, the highest values in terms of starch and HGW were obtained between the 60 cm and 50 cm row spacings respectively. According to these results, it was understood that the varieties and plant densities used significantly affected the quality criteria according to the locations.
Yeni CDK2 İnhibitörlerinin Keşfedilmesi İçin Bazı Piridazin Türevi Bileşiklerin SAR Analizi ve Kenetlenme Çalışması
Authors: Enisoğlu Atalay Vildan , Ayık Yeşim
Published: August 2022

Doğada nadir olarak bulunan ve çoğu canlının yaşamı için elzem olan makro moleküllerin yapı taşları arasında yer alan piridazinler pek çok farklı biyolojik aktiviteye sahip olan bir heterosiklik bileşik ailesidir. Bu çalışmada Ünal ve grubu tarafından sentezlenen yeni 8 farklı piridazin türevi bileşiğin DNA replikasyonu gibi önemli hücresel süreçlerde rol alan ve bu nedenle aktivitesinde gözlenen anormalliklerin kanser patolojisi ile ilişkili olduğu belirlenen siklin bağımlı kinaz 2 (CDK2) inhibitörü olabilme potansiyellerinin incelenmesi amaçlanmıştır. Bu amaç doğrultusunda bileşiklerin konformer taramaları SPARTAN’14 programı üzerinde yarı deneysel PM6 yöntemi ile, geometri optimizasyonları ve Yapı-Aktivite İlişkileri (SAR) analizleri ise HF/6-31G(d) yöntemi kullanılarak gerçekleştirilmiştir. Her bir bileşiğin çalışmanın amacı doğrultusunda seçilen aktif bölgelere moleküler kenetlenme işlemleri ise Autodock Tools-1.5.6 ve Autodock Vina programları kullanılarak gerçekleştirilmiştir. Bu çalışma sonucunda; incelenen bileşikler arasından en iyi afinite değerlerine sahip olan 1a2b (-10,8 kkal.mol-1) ve 1b2b (-10,5 kkal.mol-1) bileşiklerinin CDK2 inhibitörü olabilme potansiyellerinin yüksek olduğu belirlenmiş ve yeni antikanser ajanı ligandların tasarımında bu bileşiklerin öne çıkan özelliklerinin dikkate alınmasıyla birlikte ilgili ileri düzey çalışmaların yapılması gerektiği açığa çıkmıştır.
Relationship of photocatalysis with flavonoids in silver nanowire synthesis with herbal extract (Lavandula officinalis L.)
Authors: Kaya Havva , Kılıç Semra
Published: August 2022

Nanoparticles with unique physiochemical properties can be produced using non-toxic precursors with phyto-nano synthesis. In this study, Nanowire (AgNW) was produced from silver nanoparticles (AgNP) reduced with Lavandula officinalis L. flower extract using the phyto-nano synthesis method. The length of the produced AgNW is 1-20 µm and its diameter is approximately 40-100 nm. Although the reduction of silver was quite fast in the light environment, it was found to be slow in the dark environment. However, the effect of darkness on AgNP stabilization and AgNW formation was quite important. In addition, it was revealed that the main physical factor that enables AgNW to elongate is the mechanics of the environment provided by the centrifuge. Optical and morphological characterization of nanoparticles was done with UV-visible spectrometry and SEM. The crystal structure of the particles was determined by XRD. Energy dispersion spectrums of nanoparticles were determined by EDS. Character and size analysis was performed by TEM. FTIR determination was performed on the extracts to guide the determination of the reduction factors in light and dark. The extracts were also determined by HPLC to give an idea about the role of flavonoid content in the Ag reduction due to light. Accordingly, it was found that aromatic ring compounds with alcoholic groups effectively reduce silver in the dark and promote AgNW formation.
CuCoO2 Parçacıkları ile Yeni Metal Oksit Kompozitlerin Üretimi ve Kirleticilerin Uzaklaştırılmasında Kullanılması
Authors: Dursun Sami
Published: August 2022

Elektro-eğirme metodu ile sentezlenen metal oksit nanofiberleri üzerine hidrotermal yöntem ile sentezlenen delafosit parçacıkları ağırlıkça farklı oranlarda dekore edilerek heteroyapılı fotokatalizörler elde edilmiştir. Kalay kaynaklı metal oksitin, bakır kaynaklı delafositin ve oluşturdukları heteroyapılı malzemelerin mikroyapısal, morfolojik, optik ve elektrokimyasal özellikleri karakterize edilmiş ve bu malzemelerin başarılı bir şekilde üretildiği tespit edilmiştir. Ayrıca farklı ağırlık yüzdelerinde delafosit dekore edilen heteroyapıların aktiviteler sistematik olarak incelenmiş, en iyi sonucu veren numunenin Ağ.%0,40 delafosit içeren metal oksit nanofiberi olduğu görülmüştür. Bu fotokatalizör kullanılarak görünür ışık ışıması altında 90 dk’da metilen mavisi (MM) boyasının neredeyse tamamına yakınının (%95,8) bozunduğu tespit edilmiştir. Metal oksit nanofiber fotokatalizörüne kıyasla delafosit dekore edilmiş metal oksit fotokatalizörü MM boyasının bozunma hızında %58,5’lik bir artış sağlamıştır. Fotokatalitik aktivitedeki bu gelişme; metal oksit nanofiberinin dar bant aralığına sahip delafosit parçacıkları ile oluşturduğu heteroyapının daha fazla ışığı soğurumu sayesinde daha fazla e--h+ çifti oluşturması ile ilişkilendirilebilir.
Pengaruh Higienitas terhadap Kepuasan Pelanggan: Studi Kasus Rm. Sate Rembiga Ibu Sinaseh
Authors: Susandini Dita Yusfia , Suharti
Published: August 2022

The purpose of this study is to investigate the impact of restaurant hygiene on visitor satisfaction at the Rembiga Ibu Sinnaseh satay restaurant. This study employs one independent variable, hygienic, and one dependent variable, visitor satisfaction. The data in this study were collected by distributing questionnaires to 100 people who had visited the Rembiga Ibu Sinnaseh satay restaurant as the research sample after reviewing the literature and the field and formulating hypotheses. The sampling method used is non-probability sampling, also known as incidental sampling. The quantitative data analysis method is used, with validity tests, reliability tests, classical assumption tests, simple regression analysis, T tests, and coefficient of determination tests. The results of the analysis show that the indicators in this study are valid and reliable. The data in the classical assumption test is normally distributed, with no heteroscedasticity. The hygienic hypothesis test has a positive and statistically significant impact on visitor satisfaction. The study's findings are as follows: first, hygiene has a positive and significant effect on visitor satisfaction. This is evidenced by the hygienic significance of 0.000 0.05 and a tcount value of 7,771 that is greater than the ttable value of 1,984. Second, hygiene influences visitor satisfaction by 38.3 percent, while the rest is influenced by other factors not included in the study by 61.7 percent.
Peran Usahawan Perempuan terhadap Pengembangan Usaha Kuliner dalam Meningkatkan Kunjungan Wisatawan Pantai Loang Baloq Kota Mataram
Authors: Anwar Havivah , Muh. Baihaqi  , Atmayanti Tati , Susianti Nurul
Published: August 2022

Peran perempuan terhadap Pengembangan usaha pedagang kuliner di kawasan wisata Pantai Loang Baloq memang tidak dapat dikesampingkan lagi. Berkembangnya industri pariwisata tidak hanya didukung oleh sumber daya alam yang dimiliki akan tetapi juga karena sumber daya manusia yang memadai. Dilihat dari dukungan usaha-usaha kuliner yang disajikan oleh para pedagang ikan bakar di kawasan ini yang menjadi kuliner lokal dan mendorong pengembangan wisata kuliner secara luas. Dengan adanya kuliner ikan bakar ini maka kawasan wisata Pantai Loang Baloq dapat dikatakan kawasan yang terkenal dengan kulinernya. Selain itu juga dapat mendorong kunjungan dari para wisatawan. Penelitian ini bertujuan untuk mengetahui strategi pengembangan usha pedagang kuliner dan juga faktor-faktor yang mempengaruhi. Jenis penelitian yang digunakan untuk menganalisis data adalah metode studi kasus dengan teknik pengumpulan data berupa observasi, wawancara dan dokumentasi. Hasil penelitian menunjukan bahwa peran pedagang atau usahawan perempuan terhadap pengembangan usaha pedagang kuliner ikan bakar sudah ada sejak lama. Sebagian besar pelaku wisata kuliner ini adalah perempuan yang sangat hebat dan tangguh yang tidak hanya berperan sebagai ibu rumah tangga akan tetapi sebagai pencari nafkah dan juga berperan dalam kegiatan masyarakat. Ada beberapa faktor yang mempengaruhi strategi pengembangan usaha pedagang kuliner diantaranya adalah kebutuhan ekonomi dan ingin eksis di dunia pariwisata khususnya usaha kuliner.
Prospek Pengembangan Objek Wisata Taman Raya Lemor dalam Meningkatkan Pendapatan Masyarakat Desa Suela Kecamatan Suela Kabupaten Lombok Timur
Authors: Wirakalam Lalu , Syukriati  , Muh. Baihaqi
Published: August 2022

Pengembangan objek wisata sering dianggap sering dianggap sebagai salah satu cara untuk menghadapi berbagai masalah perekonomian di Indonesia. Pertumbuhan dan pengembangan ekonomi yang rendah dan timpang dapat diatasi dengan industri pariwisata, karena dengan adanya industri pariwisata dapan menciptakan lapangan pekerjaan yang baru dan memberikan banyak peluang ekonomi. Mengingat bahwa sebagian besar masyarakat Desa Suela sangat bergantung dari hasil hasil pertanian, maka jika terjadi kegagalan panen akan menjadi masalah ekonomi bagi masyarakat. Disamping itu dengan adanya industry wisata  memberikan peluang bagi masyarakat  sekitar untuk membuka berbagai macam usaha kecil yang mampu meningkatkan perekonomian, sebagaimana salah satu objek wisata yang menajdi objek penelitian, yaitu wisata Taman Raya Lemor. Jenis penelitian yang digunakan dalam penelitian ini, yaitu penelitian kualitatif yang bersifat deskriftif, dengan menggunakan sumber data primer dan skunder. Metode yang digunakan dalam dalam mengumpulkan data adalah observasi, wawancara dan dokumentasi. Dari hasil penelitian dapat dilihat bahwa wisata Taman Raya Lemor ini sangat berperan dalam  memperbaiki dan meningkatkan perekonomian masyarakat, memberikan peluang pekerjaan yang baru sehingga bisa mengurangi angka pengangguran. Pembangunan di sekitar sektor pariwisata ini melibatkan peran pemerintah dan masyarakat setempat. Dengan adanya pengembangan wisata yang lebih kreatif, hal tersebut mampu untuk menarik banyak wisatawan untuk berkunjung ke Taman Raya Lemor ini. Dengan  banyaknya wisatawan yang datang berkunjung akan membrikan pengaruh terhadap  peningkatan pendapatan masyarakat khususnya masyarakat di Desa Suela Kecamatan Suela Kabupaten Lombok timur.
Studies on human gut microbiota and methods of its modification in historical perspective
Authors: Szewc Monika
Published: August 2022

Termin mikrobiota (mikrobiom) wprowadził Joshua Lederberg, by nazwać nim ogół mikroorganizmów występujących w i na wszystkich organizmach wielokomórkowych. Obecnie mikrobiota jelitowa człowieka jest intensywnie badanym ekosystemem, a początki jej poznania dostrzega się w badaniach prowadzonych w XVII wieku. Prekursorem tych badań stał się Antoni van Leeuwenhoek. Rozwój metod hodowlanych, jak również biologii molekularnej umożliwił szczegółowe poznanie struktury i funkcji ludzkiego mikrobiomu, a także jego udziału w stanie zdrowia i choroby człowieka. W związku z pojawiającymi się zaburzeniami w profilu mikrobioty jelitowej człowieka i współistniejącymi z tym stanem chorobami już w starożytności stosowano fermentowane produkty mleczne jako leki w dolegliwościach żołądkowo-jelitowych. Nieco później do metod leczenia tych dolegliwości dołączyła procedura przeszczepu kału. Świadomość znaczenia tych środków przez lata ewoluowała i dziś wielu już wiadomo na temat tej metody wspomagania zdrowia. Obecnie procedura transferu mikrobioty jelitowej jest rekomendowaną metodą leczniczą zakażenia Clostridium difficile.
150 lat działalności polskich lekarzy we Lwowie
Authors: Magowska Anita
Published: August 2022

Sprawozdanie
Zbigniew Kopociński, Krzysztof Kopociński, Czesław Jeśman, Lekarze szpitala wojskowego w Żarach, Uniwersytet Medyczny w Łodzi, Żary 2014, s. 482, ilustr., ISBN 978-83-939877-0-2.
Authors: Skalski Piotr
Published: August 2022

Recenzja
Adam Wrzosek’s philosophy of medicine
Authors: Konstańczak Stefan , Oksiak-Podborączyńska Anna
Published: August 2022

Autorzy tego artykułu chcieli zrekonstruować koncepcję Adama Wrzoska filozofii medycyny. Adam Wrzosek był wybitnym polskim lekarzem, naturalistą i historykiem medycyny. Punktem wyjścia rozważań była próba określenia i zdefiniowania przedmiotu zainteresowań filozofii medycyny. Ponadto autorzy rozważali najważniejsze osiągnięcia tzw. polskiej szkoły filozofii medycyny. Filozofia medycyny uprawiana przez Adama Wrzoska, zdaniem autorów, jest adaptacją arystotelesowskiego podziału filozofii na praktyczną i teoretyczną. We wnioskach wykazano stanowisko Adama Wrzoska w kwestii potrzeby edukacji filozoficznej i zasadności odrębnego traktowania etyki dla zawodów medycznych.
Factors that Influence of Behavior to Contribution in Islamic Peer-to-Peer Lending with PLS-SEM Approach: Empirical Studies in Indonesia
Authors: Rofiqo Azidni , Suminto Ahmad , Sukoco Daud , Ramadhan M. Ali , Novita Sari Diyan
Published: August 2022

This study aims to develop a Theory of Planned Behavior by analyzing the factors that influence customers to contribute to Islamic P2P lending customers. This study uses a partial least squares structural equation model (PLS-SEM) analysis with 120 respondents. The number of respondents is determined by the five rules of thumb approach, while data collection is done by purposive sampling. This research was conducted for one year, namely in 2021-2022 with the provision that the sample was customers of Islamic P2P lending in Indonesia. The results of the study revealed that attitude, subjective norm and perceived behavior control had a significant positive effect on the intention to contribute to Islamic P2P lending. While piety and intention have a significant positive effect on behavior to contribute to Islamic P2P lending in Indonesia. The results of this study contribute to the development of the theory of planned behavior (TPB), more extensive research is needed such as research in countries that are members of the OIC to validate these results.
Keywords: Muslim Behavior, Islamic Peer-to-Peer Landing, Financial Technology
Real-Time and Historical Viral Variant Tracking
Authors: Labadorf James
Published: August 2022

Viral variant analysis is a bedrock of the disease surveillance. When combined with temporospatial analysis variant analysis can further the knowledge of disease spread in a study area. This paper suggests a method to perform the analysis in an operational setting which will allow for real-time surveillance of viral variants and allow local public health professionals to rapidly respond to changes in the evolution of the disease. This method includes three main subprocesses: preprocessing, analysis, and rendering. This method can be performed across multiple software platforms. A use case is given in which it was found that this method helped a hospital system understand the spread of SARS-CoV-2 in Northeast, Ohio.
Turbulent Eddy Generation for the CFD Analysis of Hydrokinetic Turbines
Authors: Gregori Matteo , Salvatore Francesco , Camussi Roberto
Published: August 2022

This paper presents a novel theoretical and computational methodology for the generation of an onset turbulent field with prescribed properties in the numerical simulation of an arbitrary viscous flow. The methodology is based on the definition of a suitable distribution of volume force terms in the right–hand side of the Navier–Stokes equations. The distribution is represented by harmonic functions that are randomly variable in time and space. The intensity of the distribution is controlled by a simple PID strategy in order to obtain that the generated turbulent flow matches a prescribed turbulence intensity. A further condition is that a homogeneous isotropic flow is es- tablished downstream of the region where volume force terms are imposed. Although it is general, the proposed methodology is primarily intended for the computational modelling of hydrokinetic turbines in turbulent flows representative of tidal or riverine installations. A first numerical applica- tion is presented by considering the injection of homogeneous and isotropic turbulence with 16% intensity into a uniform unbounded flow. The analysis of statistical properties as auto-correlation, power spectral density, probability density functions, demonstrates that the generated flow tends to achieve satisfactory levels of stationarity and isotropy, whereas the simple control strategy used determines overestimated turbulent intensity levels.
Agroclimatic Zone-Based Analysis of Long-Term Rainfall Trends and Variability in the Wabi Shebele River Basin, Ethiopia.
Authors: Toni Abebe Teklu , Malcherek Andreas , Kassa Asfaw Kebede
Published: August 2022

Any change in the amount and annual distribution of rainfall causes a major socioeconomic and environmental problem where rainfed agriculture is predominant. For that reason, the objective of this study was to determine the long-term variability and trends of precipitation in the Wabi Shebele River Basin (WSRB), Ethiopia. The basin was discretized into 7 local agroclimatic zones (ACZ) based on annual rainfall and elevation. In this study, the coefficient of variation (CV) was used to check the variability of rainfall and modified Mann-Kendall (MK) and Innovative Trend Analysis (ITA) methods were used to detect rainfall trends. For each ACZ, stations with long-term records and less than 10 % missing data were selected for further analysis. The mean annual rainfall in the basin ranges from 227.2 mm to 1047.4 mm. The study revealed most of the ACZs showed a very high variation in Belg/Spring season rainfall (CV % > 30) than Kiremt/Summer and annual rainfall. Trend analysis revealed that no uniform trend was detected among ACZs at each temporal scale. But, most ACZ in the arid and semi-arid areas showed a non-significant decreasing trend. In comparison, a similar result was observed using MK and ITA methods.
Hourly Wages and Turnover of Community Health Workers According to US State Certification Policy and Medicaid Reimbursement, 2010–2021
Authors: Jones Tammie M. , Jeung Chanup , Schulte Alex , Lewis Charlotte M. , Maddox Peggy J.
Published: August 2022

Objectives. To evaluate the effects of state community health worker (CHW) certification programs and Medicaid reimbursement for CHW services on wages and turnover.

Methods. A staggered difference-in-differences design was used to compare CHWs in states with and without CHW certification or CHW Medicaid reimbursement policies. Data were derived from the 2010 to 2021 Current Population Survey in the United States.

Results. CHW wages increased by $2.42 more per hour in states with certification programs than in states without programs (P = .04). Also, hourly wages increased more among White workers, men, and part-time workers (P = .04). Wages increased by $14.46 in the state with the earliest CHW certification program adoption (P < .01). Neither of the policies assessed had an effect on occupational turnover.

Conclusions. CHW wages are higher in states with certification programs. However, wage gaps exist between Whites and non-Whites and between men and women.

Public Health Implications. Federal, state, and employer-based strategies are needed to establish and sustain effective CHW programs to meet the needs of communities experiencing health and access disparities. (Am J Public Health. 2022;112(10):1480–1488. https://doi.org/10.2105/AJPH.2022.306965 )
STRATEGI PENERAPAN METODE KISAH DALAM MEMBINA AKHLAK ANAK DI TPA MASJID AN-NUR KERTOSARI BABADAN PONOROGO
Authors: Marwan Marwan , Rahmawati Fadhilah
Published: August 2022

Pembinaan akhlak merupakan pembentukan perilaku anak melalui pembiasaan yang terwujud dalam keadaan sehari-hari, hal tersebut untuk mempersiapkan sedini mungkin dalam mengembangkan sikap dan perilaku. Pada anak-anak, nilai moral akan terlihat dari mampu tidaknya seorang anak membedakan antara yang baik dan buruk. Untuk membina akhlak tersebut dibuatlah wadah berupa TPA Masjid An-Nur dimana dalam penerapan pembinaannya menggunakan metode kisah. Penelitian ini bertujuan untuk, (1). Untuk mendeskripsikan penerapan metode kisah dalam membina akhlak anak di TPA Masjid An-Nur Kertosari Babadan Ponorogo. (2). Mendeskripsikan strategi penerapan metode kisah dalam membina akhlak anak di TPA Masjid An-Nur Kertosari Babadan Ponorogo. (3). Untuk mengetahui hambatan dari strategi penerapan metode kisah dalam membina akhlak anak di TPA Masjid An-Nur Kertosari Babadan Ponorogo. Penelitian ini menggunakan metode penelitian kualitatif dengan jenis penelitian deskriptif menggunakan pendekatan studi kasus.Penelitian yang diarahkan untuk menghimpun data, mengambil makna, dan memperoleh pemahaman dari kasus tersebut.Studi kasus dapat terdiri atas satu unit atau lebih dari satu unit, tapi merupakan kesatuan.Dalam studi kasus digunakan teknik pengumpulan data seperti wawancara, observasi, studi documenter semuanya difokuskan untuk mendapatkan kesatuan data dan kesimpulan. Dari penelitian ini dapat disimpulkan bahwa penerapan metode kisah dapat memberikan pembelajaran yang menyenangkan sehingga materi mudah untuk difahami oleh anak dan dalam penerapannya metode kisah dapat memberikan pengaruh terhadap anak dalam kehidupannya sehari-hari.Guru/ustadz berperan penting dari strategi penerapan metode kisah di TPA Masjid An-Nur Kertosari Babadan Ponorogo. Hambatan dari strategi penerapan metode kisahyaitu hambatan waktu, hambatan pengelolaan kelas dan hambatan alat untuk berkisah.
KONSTRUKSI MAKKIYAH MADANIAH PADA PENAFSIRAN AYAT-AYAT KHAMR
Authors: Mahmudah Mar'atul , Munir Ahmad
Published: August 2022

Salah satu permasalahan yang direspons secara berbeda antara periode Makkah dan periode Madinah adalah masalah khamr. Hal ini terlihat pada perbedaan konstruksi ayat-ayat khamr Makkiyah dan Madaniah. Ayat-ayat khamr Makkiyah mengakui eksistensi khamr sebagai minuman yang diistimewakan masyarakat Arab Jahiliah, sedangkan ayat khamr Madaniah memandang khamr dalam bingkai sebuah permasalahan dan secara tegas serta bertahap menetapkan status hukum syariat khamr. Penelitian ini bertujuan untuk menganalisis ayat-ayat khamr dari perspektif konsep Makkiyah Madaniah. Fokus penelitian ini membahas 3 hal, pertama konstruksi ayat-ayat khamr periode Makkah dan Madinah. Kedua, penerapan konsep Makkiyah Madaniah pada penafsiran ayat-ayat khamr. Ketiga, relevansi ayat-ayat khamr dengan penanggulangan narkoba. Hasil penelitian ini menunjukkan bahwa pertama, ayat-ayat khamr Makkiyah dibangun dalam konstruksi wacana penyadaran dengan struktur ayatnya yang pendek dan sarat majas secara persuasif berusaha menggerakkan kesadaran masyarakat akan keburukan khamr. Sedangkan ayat-ayat khamr Madaniah dibangun dalam konstruksi wacana transformasi dan implementasi nilai-nilai baru untuk membentuk tatanan masyarakat baru yang ideal, dengan struktur ayatnya yang lugas, ayat khamr Madaniah secara bertahap melarang dengan tegas penggunaan khamr. Kedua, dengan penerapan konsep Makkiyah Madaniah dalam penafsiran ayat-ayat khamr diketahui bahwa penetapan hukum khamr dilakukan secara bertahap (tadarruj). Ketiga, relevansi ayat-ayat khamr dengan permasalahan narkoba di masa kini terletak pada prinsip-prinsip dasar ideal moral dan nilai universal yang terkandung dalam ayat-ayat khamr yang dapat dijadikan acuan dalam menyelesaikan masalah narkoba.
Comparison of the effects of Bosentan and Sildenafil in treatment of Patent ductus arteriosus and pulmonary arterial hypertension in preterm infants : A randomized clinical trial.
Authors: Radgoudarzi Mohammad , Mazouri Ali , Taherifard Pegah , Javid Asma , Fathi Elaheh
Published: August 2022

Background: Pulmonary arterial hypertension (PAH) is a common disorder in preterm neonates caused by patent ductus arteriosus (PDA). Although both sildenafil and bosentan have been shown to improve PAH, there is no study to compare the effect of these drugs in improving preterm infants with hemodynamically significant PDA and PAH. This study aimed to compare the therapeutic efficacy, safety, and possible side effects of combined therapies with Apotel + Bosentan, Apotel + Sildenafil, and Apotel alone in treating PDA and PAH in preterm infants. Methods: This clinical trial was conducted on 150 preterm neonates with PDA and PAH. Neonates were then divided into three groups and orally administrated with Apotel alone (10 mg/kg), Apotel (10 mg/kg) + Sildenafil (1 mg/kg), and Apotel (10 mg/kg) + Bosentan (1 mg/kg). Echocardiographic examination was performed before and 72h after the intervention. Results: Treatments with Apotel, Apotel + sildenafil, and Apotel + bosentan significantly decreased the mean of RV1, RV2, RV3, RVEDA, RVESA, RV/LV, TR intensity, TR PG, PI PG, and MPA diameter compared to before intervention (p<0.01). The mean of TAPSE after Apotel, Apotel + sildenafil, and Apotel + Bosentan administrations was significantly increased compared to before the study, indicating improvement in RV performance (p<0.01). The frequency of BPD and ROP in Apotel group (7.7% and 19.2%, respectively) was significantly lower than that in Apotel + sildenafil group (30% and 45%, respectively) and Apotel + bosentan (25% and 40%, respectively) groups (p<0.05). Conclusion: Oral administration of sildenafil and bosentan improved cardiac index beside its side effects in preterm infants PAH and PDA. Future clinical trial studies with larger sample sizes and long-term follow-up on term or near term neonates are recommended. Trial registration: IR.IUMS.FMD.REC.1399.430
Cellcano: supervised cell type identification for single cell ATAC-seq data
Authors: Ma Wenjing , Lu Jiaying , Wu Hao
Published: August 2022

Computational cell type identification (celltyping) is a fundamental step in single-cell omics data analysis. Supervised celltyping methods have gained increasing popularity in single-cell RNA-seq data because of the superior performance and the availability of high-quality reference datasets. Recent technological advances in profiling chromatin accessibility at single-cell resolution (scATAC-seq) have brought new insights to the understanding of epigenetic heterogeneity. With continuous accumulation of scATAC-seq datasets, supervised celltyping method specifically designed for scATAC-seq is in urgent need. In this work, we develop Cellcano, a novel computational method based on a two-round supervised learning algorithm to identify cell types from scATAC-seq data. The method alleviates the distributional shift between reference and target data and improves the prediction performance. We systematically benchmark Cellcano on 50 well-designed experiments from various datasets and show that Cellcano is accurate, robust, and computational efficient. Cellcano is well-documented and freely available at https://marvinquiet.github.io/Cellcano/.
Programming in The Context of Civil Engineering Education
Authors: Talaat Abdalla , Kohail Mohamed , Ahmed Sayed M.
Published: August 2022

The potential of computing in education can be easily visualized by comparing manual calculations to using spreadsheets. The various benefits range from easing repetitive tasks to visualizing data. It also grants the ability to explore without being hindered by heavy computational burdens. Programming is one computing tool that is mostly neglected in civil engineering education, where to the modern civil engineer computing may be viewed as only using commercially available software. But how can programming be used in a civil engineering class? This paper aims to answer this question by illustrating three different examples of programs written using python programming language to create impactful visualizations and engaging projects. Programming can be used in-class by educators to create visualizations and interactive sessions, or by students to train their algorithmic-thinking problem-solving skills. Though there are many barriers that obstruct implementing computing into civil engineering classes, they can be mitigated by using python.
Formulation of Biogreases derived from Mahua and Karanja Oil
Authors: Agrawal Amit , Karadbhajne Vijay , Agrawal Pratibha , Bawa Sakshi , Tiwari Richa , Mur S Srinivasan
Published: August 2022

The present study reports the parametric investigation conducted on the formulation of biofuels, biolubricant/ biogrease from Mahua (Madhuca Indica) oil and Karanja (Pongamia Pinnata) oil. Biogrease complex has been formulated in 90:10, 80:20 and 70:30 oil/soap ratios for thickness from the oils, their methyl esters and the tri-esters. The experimental results show that the biogrease prepared from Karanja TMP triester showed a drop point of 176 ℃ which was higher as compared to biogrease prepared from Mahua TMP triester which showed a drop point of 172 ℃. The water wash out resistance for both the biogreases was found to be 7%, which is comparable with conventional greases. Based on the cone penetration index, both the biogrease samples were found to fall in NLGI Grade 2 of greases, which is the most common grade of conventionally used greases. Such Biogreases can be effectively used in applications where these greases are directly released into the open atmosphere after their use like agriculture or marine machines and vehicles.
Effective factors of improved helmet use in motorcyclists: a systematic review
Authors: Sharif Pouya Mahdavi , Pazooki Sara Najafi , Ghodsi Zahra , Nouri Ahmad , Ghoroghchi Hamed Abbasizade , Tabrizi Reza , Shafieian Mehdi , Heydari Seyed Taghi , Atlasi Rasha , Sharif-Alhoseini Mahdi , Ansari-Moghaddam Alireza , O'Reilly Gerard , Rahimi-Movaghar Vafa
Published: August 2022

Background: Road traffic injuries (RTI) are one of the most prominent causes of morbidity and mortality, especially among children and young adults. Motorcycle crashes constitute a significant part of RTIs. Policymakers believe that safety helmets are the single most important protection against motorcycle-related injuries. However, motorcyclists are not wearing helmets at desirable rates. This study systematically investigated factors that are positively associated with helmet usage among the two-wheeled motorcycle riders.Methods: We performed a systematic search on PubMed, Scopus, Web of Science, Embase, and Cochrane library with relevant keywords. No language, date of publication, or methodological restrictions were applied. All the articles that had evaluated the factors associated with helmet-wearing behavior and were published before December 31, 2021, were included in our study, and underwent data extraction. To assess the quality of the included articles, we adopted the Newcastle-Ottawa Scale checklist.Results: A total of 50 articles were included. Most evidence suggests that helmet usage is more common among drivers (compared to passengers), women, middle-aged adults, those with higher educations, married individuals, license holders, and helmet owners. Moreover, the helmet usage rate is higher on highways and central city roads and during mornings and weekdays. Travelers of longer distances, more frequent users, and riders of motorcycles with larger engines use safety helmets more commonly. Non-helmet-using drivers seem to have acceptable awareness of mandatory helmet laws and knowledge about their protective role against head injuries. Importantly, the complaint about helmet discomfort is somehow common among helmet-using drivers.Conclusions: To enhance helmet usage, policymakers should emphasize the vulnerability of passengers and children to RTIs, and that fatal crashes occur on low-capacity roads and during cruising at low speeds. Monitoring by police should expand to late hours of days, weekends, and lower capacity and less-trafficked roads. Aiming to enhance the acceptance of other law-abiding behaviors (e.g., wearing seat belts, riding within the speed limits, etc.), especially among youth and young adults, will enhance the prevalence of helmet-wearing behavior among motorcycle riders. Interventions should put their focus on improving the attitudes of riders regarding safety helmets, as there is acceptable knowledge of their benefits.
On Transportation, Economic Agglomeration and CO2 Emission in China, 2003-17
Authors: yao shujie , Zhang Xiaoqian , zheng weiwei
Published: August 2022

This paper studies how transportation infrastructure affects carbon emission from the urban economic agglomeration perspective. Using 281 Chinese cities in 2003-17, a Moran’s I index is used to test the spatial distribution characteristics of transportation infrastructure and carbon emission. A spatial Durbin model is also employed to explore the spatial spillover effect of transportation infrastructure on carbon emission. In addition, economic agglomeration is used as a transmission mechanism between the two variables. The empirical results show that: ① There is a significant spatial autocorrelation between transportation infrastructure and carbon emission, which is not only affected by the relevant factors of the region under concern, but also by the similar factors of the surrounding regions; ②Transportation infrastructure significantly aggravates carbon emission, whose “neighboring effect” is surprisingly more potent than the “local effect”; ③Economic agglomeration is a valid transmission channel through which transportation infrastructure affects carbon emission, whose intensity, however, varies with the level of economic agglomeration. Cities with low economic agglomeration have a greater impact on carbon emission than those with high economic agglomeration.
Recent changes in the mutational dynamics of the SARS-CoV-2 main-protease substantiate the danger of emerging resistance to antiviral drugs.
Authors: Gruber Christian , Parigger Lena , Krassnigg Andreas , Schopper Tobias , Singh Amit , Tappler Katharina , Köchl Katharina , Hetmann Michael , Gruber Karl , Steinkellner Georg
Published: August 2022

The current COVID-19 pandemic poses a challenge to medical professionals and the general public alike. In addition to vaccination programs and nontherapeutic measures being employed worldwide to encounter SARS-CoV-2, great efforts have been made towards drug development and evaluation. In particular, the main protease (Mpro) makes an attractive drug target due to its high level characterization and relatively little similarity to host proteases. Essentially, antiviral strategies are vulnerable to the effects of viral mutation and an early detection of arising resistances supports a timely counteraction in drug development and deployment. Here we show a significant recent event of mutational dynamics in Mpro. Although the protease hasa prioribeen expected to be relatively conserved, we report a remarkable increase in mutational variability in an eight-residue long consecutive region near the active site since December 2021. The location of this event in close proximity to an antiviral-drug binding site may suggest the onset of the development of antiviral resistance. Our findings emphasize the importance of monitoring the mutational dynamics of Mprotogether with possible consequences arising from amino-acid exchanges emerging in regions critical with regard to the susceptibility of the virus to antivirals targeting the protease.
Biodegradable Products from renewable sources: Impact on Replacing Single Use Plastic for Protecting the Environment
Authors: kothakota Anjineyulu , Raghunathan Rakesh , Nelluri Puja , Rajendran Dileepmon , Pandiselvam Ravi , Thulasiraman Venkatesh , Sahoo Sushanta Kumar , Pillai Saju , Jerome Rifna Elnjikkal
Published: August 2022

Plastics are ubiquitous in many sectors including, but not limited to, construction, textiles, electronics and transportation. The immoderate use of single-use plastics has wreaked havoc on society. The intensifying environmental pollution and waste accumulation have driven the scientific communities and industries to shift their focus on biodegradable materials. An ecofriendly and sustainable economic system demands proper usage of raw materials and substitution of fossil fuel-based resources with renewable materials. Of late, bio-based constituents have attracted considerable attention from the public in view of ecological safety and economic interests. Bio-based sources are cost-effective, reusable, sustainable, clean and reduce the ecological footprint. Biopolymers can be derived from biomass (polysaccharides, proteins, lipids), bio-derived substances (polylactate) or from microorganisms (PHB, PHA, Xanthum gum). The commonly used polysaccharides include starch, cellulose, gums and chitosan. However, the hydrophilic nature of most of the polysaccharides affects the physical and mechanical properties and is not on par with the synthetic plastics that are generally used. In order to expand the applications of biodegradable polymers in various sectors, it is imperative to address the challenges associated with gas permeability, processing method, thermal stability etc. Various physical and chemical modification methods are employed to overcome these limitations. Creating awareness among the public and encouraging them to use renewable sources is important. There is a strong need to develop innovative biodegradable products and promote them by fostering collaboration among entrepreneurs, researchers and the government. This paper provides an overview of the biodegradable materials that can be produced from different sources such as vegetable and fruit waste, cereals and pulses waste, seaweeds, animal waste, wood waste, traditional sources and aims to address the current limitations and indicate the future directions.
Evaluation of immunological characteristics and prognosis in melanoma patients using an endoplasmic reticulum stress-associated signature based on bioinformatic analysis
Authors: Hounye Alphonse Houssou , Hu Bingqian , Wang Zheng , Wang Jiaoju , Cao Cong , Zhang Jianglin , Hou Muzhou , Qi Min
Published: August 2022

Purpose: We aimed to develop endoplasmic reticulum (ER) stress-related risk signature to predict the prognosis of melanoma and elucidate the immune characteristics and benefit of immunotherapy in ER-related risk score-defined subgroups of melanoma based on a machine learning algorithm.Methods: Based on The Cancer Genome Atlas (TCGA) melanoma dataset (n = 471) and GTEx database (n=813), 365 differentially expressed ER-associated genes were selected using the univariate Cox model and Lasso penalty Cox model. Ten genes impacting OS were identified to construct an ER-related signature by using the multivariate Cox regression method and validated with the Gene Expression Omnibus (GEO) dataset. Thereafter, the immune features and the clinical benefit of anticancer immune checkpoint inhibitor (ICI) therapy in risk score subgroups were analysed.Results: The ER-related risk score was constructed based on the ARNTL, AGO1, TXN, SORL1, CHD7, EGFR, KIT, HLA-DRB1 KCNA2, and EDNRB genes. The high ER stress-related risk score group patients had a poorer overall survival (OS) than the low-risk score group patients, consistent with the results in the GEO cohort. The combined results suggested that a high ER stress-related risk score was associated with cell adhesion, gamma phagocytosis, cation transport, cell surface cell adhesion, KRAS signalling, CD4 T cells, M1 macrophages, naive B cells, natural killer (NK) cells, and eosinophils and less benefitted from ICI therapy.Conclusion: Based on the expression patterns of ER stress-related genes, we created an appropriate predictive model, which can also help distinguish the immune characteristics and the clinical benefit of ICI therapy.
Vitis vinefera L. DNA preparation for third-generation sequencing
Authors: Bibi Androniki C , Kollias Anastasios , Astrinaki Maria , Vassou Despoina , Kafetzopoulos Dimitris , Kalantidis Kriton , Moschou Panagiotis N.
Published: August 2022

Several approaches have been proposed to sequence the genome of Vitis vinifera L. (grapevine), utilizing low-resolution second-generation platforms that lead to partial coverage and low-quality reads. Nevertheless, the characterization of the grapevine genetic resources could be better addressed through extensive and high-resolution genome sequencing. MinION is a third-generation sequencer preferred by many laboratories due to its relatively low cost, ease of use, and small size. To exploit MinION at its full potential, it requires high-quality DNA which is difficult to obtain in grapevine. Here we establish a workflow for DNA for MinION sequencing long reads from grapevine. This protocol was tested with undeveloped leaves, apex, helices, petioles, and 4th leaves samples. In addition, a circulomic size selection approach was tested to provide an unparalleled size of DNA reads. Our results suggest that longer reads of grapevine DNA associate with the use of fresh undeveloped tissue and adjusted conditions for the purification of cell nuclei. Short read elimination protocol increased N50 read length with a reasonable compromise for overall data yield. Our workflow presents a significant advancement for long-read quality DNA isolation for grapevine, providing also technical considerations for high-quality DNA preparation compatible with MinION from plants.