bluuebunny/crossref_metadata_2025 huggingface dataset:
A Systematic Review on the Effect of Saffron Extract on Lipid Profile in Hyperlipidaemic Experimental Animal Models
Authors:   Institute of Pathology, Laboratory and Forensic Medicine (I-PperForM), Universiti Teknologi MARA, Selangor, Malaysia, Abd Rahim Iman Nabilah , Mohd Kasim Noor Alicezah ,   Institute of Pathology, Laboratory and Forensic Medicine (I-PperForM), Universiti Teknologi MARA, Selangor, Malaysia,   Department of Pathology, Faculty of Medicine, Universiti Teknologi MARA, Selangor, Malaysia, Isa Mohamad Rodi ,   Department of Population Health and Preventive Medicine, Faculty of Medicine, Universiti Teknologi MARA, Selangor, Malaysia, Nawawi Hapizah ,   Institute of Pathology, Laboratory and Forensic Medicine (I-PperForM), Universiti Teknologi MARA, Selangor, Malaysia,   Department of Pathology, Faculty of Medicine, Universiti Teknologi MARA, Selangor, Malaysia
Published: August 2022

Saffron is widely used in traditional medicine to treat various medical disorders, including hyperlipidaemia. This study aims to systematically review the effects of saffron extract (SE) on lipid profile in in vivo studies. A strategic literature search was done following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The Scopus, PubMed (MEDLINE) and Web of Science databases and hand-searching methods were utilised to identify studies published up to January 2020 that reported the effects of SE on lipid profile in a hyperlipidaemic experimental animal model. A total of six articles met the inclusion criteria. The methods of extraction were aqueous (n = 4), ethanolic (n = 1) and hydroalcoholic (n = 1) extracts. Five doses of SE ranging from 10 mg/kg to 100 mg/kg were administered to rats and hamsters, with a duration ranging from 10 days to 8 weeks. SE at doses of 40 mg/kg/day and 80 mg/kg/day significantly decreased the levels of total cholesterol (21.4%–35.4%), low-density lipoproteins (38.7%–50.0%) and triglycerides (TGs) (29.1%–45.0%) and markedly increased the level of high- density lipoproteins (36.6%–65%) in the treated group compared to the untreated group with a minimum 3-week intervention duration (P < 0.05). This systematic review demonstrated that SE exhibits hypolipidaemic effects compared to a placebo. SE has almost the same ability to reduce cholesterol levels as the standard therapy.
Diagnostic Accuracy of Centor Score for Diagnosis of Group A Streptococcal Pharyngitis among Adults in Primary Care Clinics in Malaysia
Authors:   Department of Medical Microbiology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia, Muthanna AbdulRahman ,   Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia, Shamsuddin Nurainul Hana ,   Department of Family Medicine, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia, Abdul Rashid Aneesa ,   Department of Family Medicine, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia, Shariff Ghazali Sazlina ,   Department of Family Medicine, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia, Hamat Rukman Awang ,   Department of Medical Microbiology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia, Mawardi Maliza ,   Department of Family Medicine, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia, Salim Hani Syahida ,   Department of Family Medicine, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia, Zakariah Siti Zulaikha ,   Department of Medical Microbiology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia
Published: August 2022

Background: Pharyngitis is a common presentation seen in general practice, but it is difficult to differentiate whether its etiology is viral or bacterial. The Centor score gives an approximation of the etiology of the pharyngitis, which informs physicians of the need to prescribe antibiotics. This study aimed to assess the validity of the Centor score in diagnosing Group A streptococcal (GAS) pharyngitis amongst adults in Malaysia. Methods: This cross-sectional study was conducted to compare the clinical criteria of the Centor score to the gold standard throat swab culture results amongst 215 adults presenting with sore throat in primary care clinics. The participants were adult patients who complained of sore throat and visited the three public primary care clinics in Sepang, Malaysia. The convenience sampling method was used. The throat swabs were analysed for β-haemolytic streptococci. Demographic and clinical data, including the Centor score, were analysed in relation to the pathogen. Results: Pharyngitis was diagnosed in 130 (60.5%) of the participants. Six isolates (2.4%) were identified as GAS pharyngitis. Both Centor scores 3 and 4 had a sensitivity of 50%, and specificities of 97.6% and 100%, respectively. Conclusion: A Centor score < 3 is favourable for excluding a diagnosis of GAS pharyngitis. Centor scores 3 and 4 require further examination to confirm a diagnosis of GAS pharyngitis.
Hole-induced anomaly in the thermodynamic behavior of a one-dimensional Bose gas
Authors: De Rosi Giulia , Rota Riccardo , Astrakharchik Gregory , Boronat Jordi
Published: August 2022

We reveal an intriguing anomaly in the temperature dependence of the specific heat of a one-dimensional Bose gas.~The observed peak holds for arbitrary interaction and remembers a superfluid-to-normal phase transition in higher dimensions, but phase transitions are not allowed in one dimension.~The presence of the anomaly signals a region of unpopulated states which behaves as an energy gap and is located below the hole branch in the excitation spectrum.~The anomaly temperature is found to be of the same order of the energy of the maximum of the hole branch.~We rely on the Bethe Ansatz to obtain the specific heat exactly and provide interpretations of the analytically tractable limits.~The dynamic structure factor is computed with the Path Integral Monte Carlo method for the first time.~We notice that at temperatures similar to the anomaly threshold, the energy of the thermal fluctuations become comparable with the maximal hole energy, leading to a qualitative change in the structure of excitations.~This excitation pattern experiences the breakdown of the
quasiparticle description for any value of the interaction strength at the
anomaly, similarly to any superfluid phase transition at the critical
temperature.~We provide indications for future observations and how the hole anomaly can be employed for in-situ thermometry, identifying different collisional regimes and understanding other anomalies in atomic, solid-state, electronic, spin-chain and ladder systems.
Assessment of war effects on the publishing activity and scientific interests of Ukrainian scholars
Authors: Fiialka Svitlana
Published: August 2022

This paper highlights war effects on publication activities and scientific interests of Ukrainian researchers. Moreover, it presents the moods and motives of Ukrainian scientists regarding their scientific activity and the publication of their results in academic journals. The research method was a survey (Google Forms) distributed through Facebook professional groups “Ukrainian Scientists Worldwide,” “Ukrainian cuisine of scientific publications,” “Scientific Conferences and Publications,” and “Higher School and Science of Ukraine: Disintegration or Blossoming?” 690 Ukrainian scientists took part in the survey. Only 35.7% of the respondents stated that the war did not affect their research process. Results from respondents demonstrated that 27.7% of the respondents changed their scientific interests because of full-scale Russian aggression. Furthermore, scientists have psychological problems due to the loss of home, relatives, and relocation. The survey showed that motivation for publishing scientific articles varies from informing colleagues of their scientific results, scientific interest to motives distant from scientific values – “fulfillment of the requirements of the institution where I work,” “I do not want to be fired,” etc. 20.0% of the respondents noted that they had not got any motivation for scientific activity and publishing. At the same time, most scientists consider state security, debunking the propaganda of the Russian Federation, economic development, military medicine, ecology, education, social sphere, and agriculture to be the leading research areas. They also see the need to raise public awareness of the role of science and synchronize current multidisciplinary scientific research.
Simulation of diffuse source polluted water environment based on MIKE21: A case study of the urban section of the Bai river
Authors: Zhang Xianqi , Wu Xilong , Zhu Guoyu , Wang Tao , Chen Haiyang
Published: August 2022

Affected by urban construction and industrial discharge, the diffuse source pollution of river water environment in urban sections is becoming more and more serious. The use of numerical models can accurately and efficiently simulate the process of diffuse source pollution and analyze its evolution. Based on MIKE21, the urban river water environment model of the Bai river is constructed. After parameter calibration, it is proved that the model has high accuracy. Based on the discharge of this river section in 2018, the river diffuse source pollution is simulated under three hydrological conditions, and the BP neural network is used to simulate the river diffuse source pollution. Network assessment of water quality in dry years. The results showed that the four water quality indicators showed the spatial distribution characteristics of upstream>urban section>downstream, and the river water quality in the year showed the temporal distribution characteristics of flood season better than a non-flood season. The mean value of the coefficient of certainty R2 reaches 0.94 when comparing the simulated and measured values, which indicates that the model has high applicability and satisfactory fit. If the water quality of the water year does not meet the standard, the diffuse source pollution discharge should be reduced from May to October. This study can provide reference and guidance for urban river diffuse source pollution control.
Circ_0006789 Promotes the Progression of Hepatocellular Carcinoma
Cells via Modulating miR-1324 and SOX12
Authors: Cai Yu , Jia Yuanyuan , Yan Pu , Chang Xiaowei , Li Wujun , Cai Bin
Published: August 2022

Background:

Circular RNAs (circRNAs) exert an important regulatory effect on cancer
progression. Reportedly, circRNAs can modulate gene expression by working as molecular sponges
for miRNAs. Nonetheless, many functional circRNAs in hepatocellular carcinoma (HCC) remain to
be identified. This study aimed to explore the role of hsa_circ_0006789 (circ_0006789) in HCC.

Methods:

The expression profile of circRNAs in HCC tumor tissues was analyzed using circRNA
microarray data. Circ_0006789 expression in HCC tissues and cell lines was examined by qPCR.
After circ_0006789 was overexpressed or knocked down in HCC cell lines, HCC cell growth,
migration and invasion were evaluated by the CCK-8 method and Transwell experiment. RIP assay,
RNA pull-down assay, dual-luciferase reporter experiment and Western blotting were adopted to
investigate the regulatory mechanism among circ_0006789, microRNA (miR)-1324 and SRY (sex
determining region Y)-box 12 (SOX12).

Results:

Circ_0006789 was overexpressed in HCC tissues and cell lines. Circ_0006789
overexpression accelerated the growth, migration and invasion of HCC cells, while knockdown of
circ_0006789 exerted the opposite effects. miR-1324 was confirmed as a target of circ_0006789,
and miR-1324 targeted SOX12 to suppress its expression. Circ_0006789 could promote SOX12
expression by sponging miR-1324.

Conclusion:

Circ_0006789 modulates the growth, migration and invasion of HCC cells by
regulating miR-1324/SOX12 axis.
Physiological Properties, Functions, and Trends in the Matrix Metalloproteinase
Inhibitors in Inflammation-Mediated Human Diseases
Authors: Kim Il-Sup , Yang Woong-Suk , Kim Cheorl-Ho
Published: August 2022

Introduction:

Zn2+-containing endo-type peptidases directly degrade and remodel the ECM region in the progression of various diseases. MMPs are frequently found in abnormal disease status of inflammatory responses, periodontal lesion, inflammatory pulmonary lesion, arteriosclerotic smooth muscles, arthritis, and tumor metastasis and invasion. They are also known to participate in aging processes—such as wrinkle formation—by destroying collagen in the dermis. In particular, the onset of diseases via the MMP-dependent inflammatory response is caused by the breakdown of proteins in the ECM and the basement membranous region, which are the supporting structures of cells.

Methods:

This review describes the developments in the research examining the general and selective inhibitors for MMP associated with various human diseases over the past 20 years in terms of structure remodeling, substrate-recognizing specificities, and pharmacological applicability.

Results:

Among two similar types of MMPs, MMP-2 is known as gelatinase-A with a 72 kDa, while MMP-9 is termed as gelatinase-B with a 92 kDa. Both of these play a key role in this action. Therefore, both enzymatic expression levels coincide during the onset and progression of diseases. Endogenous tissue inhibitors of matrix metalloproteinases (TIMPs) are highly specific for each MMP inhibitor type. The intrinsic factors regulate various MMP types by inhibiting the onset of various diseases mediated by MMP-dependent or independent inflammatory responses. The MMP-9 and MMP-2 enzyme activity related to the prognosis of diseases associated with the inflammatory response are selectively inhibited by TIMP1 and TIMP2, respectively. The major pathogenesis of MMP-mediated diseases is related to the proliferation of inflammatory cells in various human tissues, which indicates their potential to diagnose or treat these diseases. The discovery of a substance that inhibits MMPs would be very important for preventing and treating various MMP-dependent diseases.

Conclusion:

Considerable research has examined MMP inhibitors, but most of these have been synthetic compounds. Research using natural products as MMP inhibitors has only recently become a subject of interest. This review intends to discuss recent research trends regarding the physiological properties, functions, and therapeutic agents related to MMPs.
Detection of Acute Optic Neuritis using Contrast-Enhanced 3-Dimensional
Cube T1-Weighted Imaging: A Preliminary Study
Authors: Yang Renjie , Qu Bing , Liu Weiyin Vivian , Liu Changsheng , Chen Ting , Li Liang , Zha Yunfei
Published: August 2022

Objective:

We aimed to assess whole-brain imaging with contrast-enhanced (CE) 3-
dimensional (3D) Cube T1WI in improving the diagnostic accuracy of acute optic neuritis (ON)
compared to conventional CE 2-dimensional (2D) T1WI.

Methods:

At a field strength of 3 T, CE 3D Cube T1-weighted and conventional CE 2D T1-
weighted MR images were retrospectively analyzed for 32 patients (64 optic nerves) with clinically
confirmed acute ON. The study cohort included 36 pathological nerves. Image assessments including
the overall image quality, clarity of the optic nerve, and visual contrast enhancement were performed
by two blinded neuroradiologists using a 4-point scale. The sensitivity, specificity, and
accuracy of the conventional 2D T1WI and 3D Cube T1WI were calculated according to the clinical
diagnosis.

Results:

The application of 3D Cube T1WI improved the overall image quality compared to 2D
Ax T1WI and 2D Cor T1WI (P < 0.05). The clarity of the optic nerve and the visual contrast enhancement
were higher for the 3D Cube T1WI compared to the 2D Ax T1WI and 2D Cor T1WI
for at least one reader. The sensitivity, specificity, and accuracy were 89%, 86%, 88% for the 3D
Cube T1WI respectively, and 75%, 79%, 77% for the conventional 2D T1WI respectively. The
lesions detected by the conventional 2D T1WI were all detected by the 3D Cube T1WI.

Conclusion:

Our data show that whole-brain imaging with CE 3D Cube T1WI is a viable alternative
for the detection of acute ON without sacrificing scanning efficiency.
Integrative Multi-Omics Analysis of Identified Ferroptosis-Marker RPL8
as a Candidate Oncogene Correlates with Poor Prognosis and Immune
Infiltration in Liver Cancer
Authors: Fan Shunli , Zhang Sai , Kong Dejun , Wang Hao , Shi Yuan , Wang Zhenglu , Zheng Hong
Published: August 2022

Background:

Liver Hepatocellular Carcinoma (LIHC) is characterized by high malignancy,
poor prognosis, and high recurrence rate worldwide. The role of ferroptosis in tumorigenesis
and progression has been confirmed in previous studies. However, the multi-omics analysis in liver
cancer of ferroptosis-markers RPL8 remains to be elucidated.

Methods:

In this analysis, the RPL8 mRNA expression was analyzed via the GEPIA, TIMER and
UALCAN databases. In addition, we verified the mRNA expression of RPL8 by qRT-PCR experiment.
The Kaplan-Meier plotter, UALCAN, TCGAportal and HPA databases were applied to evaluate
RPL8 on prognosis and clinicopathological parameters. Moreover, we used TIMER and
Kaplan-Meier plotter to analyze the correlation of RPL8 to immune cell infiltration and immune cell
type markers to prognosis. In addition, networks and function enrichment between RPL8 coexpression
genes were analyzed by GeneMANIA, cBioportal and Metascape databases. What’s
more, we used FerrDb and GEPIA databases to analyze the correlation of 23 Ferroptosis-related
genes with RPL8.

Results:

The mRNA expression of RPL8 was over-expressed in multiple cancers. In addition, transcription
and translation levels of RPL8 in LIHC were significantly higher than normal tissues. Furthermore,
higher expression of RPL8 was closely related to shorter OS in LIHC patients. The analysis
of Kaplan-Meier plotter proved that RPL8 expression was related to stage, Sorafenib treatment,
alcohol consumption and hepatitis virus. Moreover, the results showed that the methylation expression
level of RPL8 was significantly associated with age, gender, grade, stage and TP53 mutation of
LIHC. RPL8 and its co-expression genes were primarily involved in liver regeneration and immune
system process. Immune infiltration analysis showed the RPL8 expression had positively correlated
with immune cells and immune subtypes in LIHC. Furthermore, qRT-PCR experiment validated the
expression difference of RPL8 in liver cancer.

Conclusion:

Our findings elucidated that ferroptosis-markers RPL8 may play an important role in
prognosis, and significantly correlate with ferroptosis-related genes, it also revealed the potential of
RPL8 as a novel therapeutic target for LIHC treatment and prognosis assessment.
Pharmacokinetic Study of Vadadustat and High-Resolution Mass Spectrometric
Characterization of its Novel Metabolites in Equines for the Purpose of Doping
Control
Authors: Ishii Hideaki , Shibuya Mariko , Kusano Kanichi , Sone Yu , Kamiya Takahiro , Wakuno Ai , Ito Hideki , Miyata Kenji , Sato Fumio , Kuroda Taisuke , Yamada Masayuki , Leung Gary Ngai-Wa
Published: August 2022

Background:

Vadadustat, a hypoxia-inducible factor prolyl hydroxylase (HIF-PHD) inhibitor, is a substance
which carries a lifetime ban in both horse racing and equestrian competition. A comprehensive metabolic
study of vadadustat in horses has not been previously reported.

Objective:

Metabolism and elimination profiles of vadadustat in equine plasma and urine were studied for the purpose
of doping control.

Methods:

A nasoesophageal administration of vadadustat (3 g/day for 3 days) was conducted on three thoroughbred
mares. Potential metabolites were comprehensively detected by differential analysis of full-scan mass spectral data
obtained from both in vitro studies with liver homogenates and post-administration samples using liquid chromatography
high-resolution mass spectrometry. The identities of metabolites were further substantiated by product ion
scans. Quantification methods were developed and validated for the establishment of the excretion profiles of the
total vadadustat (free and conjugates) in plasma and urine.

Results:

A total of 23 in vivo and 14 in vitro metabolites (12 in common) were identified after comprehensive analysis.
We found that vadadustat was mainly excreted into urine as the parent drug together with some minor conjugated
metabolites. The elimination profiles of total vadadustat in post-administration plasma and urine were successfully
established by using quantification methods equipped with alkaline hydrolysis for cleavage of conjugates such as
methylated vadadustat, vadadustat glucuronide, and vadadustat glucoside.

Conclusion:

Based on our study, for effective control of the misuse or abuse of vadadustat in horses, total vadadustat
could successfully be detected for up to two weeks after administration in plasma and urine.
HIV and COVID-19: A Tale of Two Pandemics
Authors: Kurdekar Aditya , Verma Shruti , Venkataramaniah Kamisetti
Published: August 2022

In the last 5 decades, we have witnessed two major pandemics, AIDS caused by the Human
Immunodeficiency Virus (HIV) and the CoronaVirus Disease-19 (COVID-19) caused by the
Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2). The emergence of COVID-19
has raised many concerns for researchers, doctors, patients, and other institutions associated with
HIV. A lot of debate has persisted on clinical outcomes, the use of antiretrovirals, and vaccines on
HIV patients infected with COVID-19. This note attempts to present different aspects of HIV and
SARS-CoV-2 across themes like SARS-CoV-2 coinfections in people living with HIV, the psychological
impact, treatments, vaccination, etc. We highlight how learnings from the COVID-19 pandemic
can help us in tackling the HIV pandemic.
Myositis Associated with the Anti-COVID-19 Covishield Vaccine
Authors: Miqdadi Amal , Benmansour Nouhad , Herrag Mohammed
Published: August 2022

Introduction:

The SARS-CoV-2 made the world stop its activities, and the only chance
of returning to normal life is the vaccine. But like any vaccination, some complications have been
reported. We report the case of a patient who presented a myositis following the administration of
the Covishield* (AZD1222, ChAdOx1 nCoV-19, AstraZeneca) Covid-19 vaccine.

Case Report:

12 hours after his first dose, an 84-year-old patient presented to us reporting a decreased muscle strength: the patient can move against gravity but not against resistance. The biological
assessment showed that CK was at 4,250 IU/L, myoglobin was at 144 microgram/L and aldolases at
16.9 U/L. The patient received high doses of corticosteroids.

Discussion:

The development of vaccines and immunization programs reduced the morbidity and
mortality of several diseases. Other case reports suggested the possible association between myopathies and the administration of the hepatitis B vaccine and H1N1 plus the seasonal trivalent influenza and other vaccines. The exact mechanism is still unknown, but a presumable autoimmune phenomenon is incriminated.

Conclusion:

The main purpose of this case report is to raise awareness about the possible link between the Covid-19 vaccination and polymyositis and the urge to take charge to avoid further complications.
Oral Squamous Cell Carcinoma Following Acute Methotrexate Toxicity in
a Psoriasis Patient: A Causal Association or Mere Co-Incidence
Authors: Choudhary Ritul , Singh Ajeet , Chhabra Namrata , Gupta Ashish Kumar
Published: August 2022

Background:

Methotrexate is an antimetabolite anticancer drug frequently used in the
treatment of extensive chronic plaque psoriasis. Psoriasis patients on treatment with immunosuppressants
have an increased risk of developing malignancies.

Objective:

To present a rare case of Oral Squamous Cell Carcinoma (OSCC) in a psoriasis patient
postacute methotrexate toxicity.

Case Report:

A 47-year-old female, a known case of chronic plaque psoriasis for which she was on
15 mg/ week methotrexate therapy and accidentally consumed 15 mg for 7 consecutive days. She
was successfully treated for methotrexate toxicity and 45 days later she presented with exophytic
growth on the tongue. Histopathology confirmed the diagnosis of squamous cell carcinoma and the
patient underwent surgical resection.

Conclusion:

There could be a causal association between psoriasis and OSCC in the setting of acute
methotrexate toxicity, as in the present case.
Study of the Antihypertensive and Vasorelaxant Activities of Haloxylon
scoparium in Rats
Authors: Eddouks Mohamed , Amtaghri Smail
Published: August 2022

Aims:

The work aimed to study the antihypertensive ability of Haloxylon Scoparium.

Background:

Haloxylon Scoparium Pomel is used to treat various diseases including hypertension.

Objective:

This study aimed to evaluate the antihypertensive effect of Haloxylon scoparium (H. scoparium) in hypertensive rats, and to evaluate its probable vasorelaxant activity.

Material and Methods:

The aqueous extract of Haloxylon scoparium (AEHS) was prepared and used to investigate its antihypertensive ability in L-NAME(Nω-L-arginine methyl ester)-induced hypertensive rats, and its vasorelaxant activity was studied on the isolated thoracic aorta of rats. The acute and subchronic effects of (AEHS) on blood pressure parameters were evaluated after oral administration of AEHS (60 and 100 mg/kg body weight) for 6 h for the acute experiment and for 7 days for the subchronic test.

Results:

The results indicated that AEHS decreased blood pressure parameters (systolic, mean, and diastolic blood pressure) after repeated oral administration in hypertensive rats without affecting normal rats. In addition, AEHS (375-1250 μg/mL) revealed a vasorelaxant effect in thoracic aortic rings precontracted with norepinephrine (NE) (10 µM) or KCl (80 mM). This effect was partially decreased in the presence of nifedipine, by inhibition of the vascular calcium channel pathway in isolated rat thoracic aorta.

Conclusion:

The study demonstrates the beneficial effect of Haloxylon scoparium as an antihypertensive agent. Moreover, this plant exerts vasorelaxant activity via blockade of Ca2+ channels.
Novel Applications of Graphene and its Derivatives: A Short Review
Authors: Jose Jephin K. , Jose Amal , Job Akhila , Balachandran Manoj
Published: August 2022

Graphene, a layered allotropic form of graphitic carbon, has fascinated the scientific world
since its discovery. Its unique structural, physical, chemical, mechanical, and electrical properties find
application in many areas. Because of its large surface area and its apt electrical property, it is used in
electromagnetic interference shielding. With excellent carrier mobility, it is used for sensing purposes.
Mechanical strength and elastic properties coupled with its lightweight make graphene a promising
material as a supercapacitor. The 2-dimensional structural properties of the graphene layers can be
used for the purification treatment of water and gas. The number of research in graphene applications
is increasing every day, showing the importance and excellency of graphene properties. This short review
provides a comprehensive understanding of graphene's properties and progress in electromagnetic
interference shielding, sensors, water treatment, energy production, storage, and conversion applications
such as supercapacitors, fuel cells, solar cells and electrocatalysts.
Association Between COVID-19 Pandemic and Serious Mental Illness: Systematic Review within Salutogenesis Model for Public Health Management
Authors: Kaman Sweta , Sharma Ankita , Banerjee Romi
Published: August 2022

Background:

The outbreak of the COVID-19 pandemic, the constant transformation of the SARS-COV-2 virus form, exposure to substantial psychosocial stress, environmental change, and isolation have led to the inference that the overall population's mental health could be affected, resulting in an increase in cases of psychosis.

Objective:

We initiated a systematic review to determine the impact of the SARS-COV-2 virus and its long-term effects - in both symptomatic and asymptomatic cases - on people with or without psychosis. We envisioned that this would give us an insight into effective clinical intervention methods for patients with psychosis during and after the pandemic.

Method:

We selected fifteen papers that met our inclusion criteria, i.e., those that considered participants with or without psychiatric illness and exposed to SARS-COV-2 infection, for this review and were retrieved via Google, Google Scholar, MEDLINE, PubMed, and PsychINFO Database.

Key Gap:

There is a dearth of research in understanding how COVID-19 affects people with or without a prior personal history of psychosis.

Results:

The systematic review summary provides insight into the state of knowledge. Insights from the systematic review have also been reviewed from the salutogenesis model's perspective. There is moderate evidence of new-onset psychosis during the COVID-19 pandemic in which some antipsychotics treated the psychotic symptoms of patients while treating for COVID-19. Suggestions and recommendations are made for preventive and promotive public health strategies.

Conclusion:

The Salutogenesis model and Positive Psychology Interventions (PPI) provide another preventive and promotive public health management approach.
Literature Review on Development of Feature Selection and Learning
Mechanism for Fuzzy Rule-Based System
Authors: Kumar Ankur , Kaur Avinash
Published: August 2022

This research is being conducted to study fuzzy system with improved rule base. Rule base is an important part of any fuzzy inference system designed. Rules of a fuzzy system depend on the number of features selected. Selecting an optimized number of features is called feature selection. All features (parameters) play an important role in the input to the system, but they have a different impact on the system performance. Some features do not even have a positive impact of classifier on multiple classes. Reduced features, depending on the objective to be achieved require fewer training rules, Thereby, improving the accuracy of the system. Learning is an important mechanism to automate fuzzy systems. The overall purpose of the research is to design a general fuzzy expert system with improvements in the relationship between interpretability and accuracy by improving the feature selection and learning mechanism processes through nature-inspired techniques or innovating new methodologies for the same.
Social Media Impact of Articles Published by Dermatology Residents During Medical School: Cross-sectional Study
Authors: Huang Austin , Zhu Harrison , Zhou Kelvin , Kirby R Parker , Dasari Nina , Calderara Gianmarco A , Cordova Kathryn , Sorensen Ryan , Bhatnagar Anshul , Kim Soo Jung
Published: August 2022

Background

The Altmetric score (AS) is a novel measure of publication impact that is calculated by the number of mentions across various social media websites. This method may have advantages over traditional bibliometrics in the context of research by medical students.

Objective

This study aimed to determine whether dermatology matriculants who graduated from higher-ranked medical schools published more articles with greater impact (ie, a higher AS) than those from lower-ranked institutions.

Methods

A PubMed search for articles published by dermatology residents who started medical school in 2020 was conducted. Demographic information and Altmetric data were collected, and medical schools were sorted according to US News’ top-25 and non–top-25 categories.

Results

Residents who completed their medical training at a top-25 institution published more papers (mean 4.93, SD 4.18 vs mean 3.11, SD 3.32; P<.001) and accrued a significantly higher total AS (mean 67.9, SD 160 vs mean 22.9, SD 75.9; P<.001) and average AS (mean 13.1, SD 23.7 vs mean 6.71, SD 32.3; P<.001) per article than those who graduated from non–top-25 schools.

Conclusions

Our results indicate that students in top-25 schools may have greater access to research resources and opportunities. With a pass/fail United States Medical Licensing Examination Step 1 exam that may increasingly shift focus toward scholarly output from medical students, further discussion on how to create a more equitable dermatology match is essential.
An Evaluation of Primary Studies Published in Predatory Journals Included in Systematic Reviews From High-Impact Dermatology Journals: Cross-sectional Study
Authors: Ottwell Ryan , Hightower Brooke , Failla Olivia , Snider Kelsey , Corcoran Adam , Hartwell Micah , Vassar Matt
Published: August 2022

Background

Predatory publishing is a deceptive form of publishing that uses unethical business practices, minimal to no peer review processes, or limited editorial oversight to publish articles. It may be problematic to our highest standard of scientific evidence—systematic reviews—through the inclusion of poor-quality and unusable data, which could mislead results, challenge outcomes, and undermine confidence. Thus, there is a growing concern surrounding the effects predatory publishing may have on scientific research and clinical decision-making.

Objective

The objective of this study was to evaluate whether systematic reviews published in top dermatology journals contain primary studies published in suspected predatory journals (SPJs).

Methods

We searched PubMed for systematic reviews published in the top five dermatology journals (determined by 5-year h-indices) between January 1, 2019, and May 24, 2021. Primary studies were extracted from each systematic review, and the publishing journal of these primary studies was cross-referenced using Beall’s List and the Directory of Open Access Journals. Screening and data extraction were performed in a masked, duplicate fashion. We performed chi-square tests to determine possible associations between a systematic review’s inclusion of a primary study published in a SPJ and particular study characteristics.

Results

Our randomized sample included 100 systematic reviews, of which 31 (31%) were found to contain a primary study published in a SPJ. Of the top five dermatology journals, the Journal of the American Academy of Dermatology had the most systematic reviews containing a primary study published in an SPJ. Systematic reviews containing a meta-analysis or registered protocol were significantly less likely to contain a primary study published in a SPJ. No statistically significant associations were found between other study characteristics.

Conclusions

Studies published in SPJs are commonly included as primary studies in systematic reviews published in high-impact dermatology journals. Future research is needed to investigate the effects of including suspected predatory publications in scientific research.
Associations Between Depression Symptom Severity and Daily-Life Gait Characteristics Derived From Long-Term Acceleration Signals in Real-World Settings: Retrospective Analysis
Authors: Zhang Yuezhou , Folarin Amos A , Sun Shaoxiong , Cummins Nicholas , Vairavan Srinivasan , Qian Linglong , Ranjan Yatharth , Rashid Zulqarnain , Conde Pauline , Stewart Callum , Laiou Petroula , Sankesara Heet , Matcham Faith , White Katie M , Oetzmann Carolin , Ivan Alina , Lamers Femke , Siddi Sara , Simblett Sara , Rintala Aki , Mohr David C , Myin-Germeys Inez , Wykes Til , Haro Josep Maria , Penninx Brenda W J H , Narayan Vaibhav A , Annas Peter , Hotopf Matthew , Dobson Richard J B ,   RADAR-CNS Consortium
Published: August 2022

Background

Gait is an essential manifestation of depression. However, the gait characteristics of daily walking and their relationships with depression have yet to be fully explored.

Objective

The aim of this study was to explore associations between depression symptom severity and daily-life gait characteristics derived from acceleration signals in real-world settings.

Methods

We used two ambulatory data sets (N=71 and N=215) with acceleration signals collected by wearable devices and mobile phones, respectively. We extracted 12 daily-life gait features to describe the distribution and variance of gait cadence and force over a long-term period. Spearman coefficients and linear mixed-effects models were used to explore the associations between daily-life gait features and depression symptom severity measured by the 15-item Geriatric Depression Scale (GDS-15) and 8-item Patient Health Questionnaire (PHQ-8) self-reported questionnaires. The likelihood-ratio (LR) test was used to test whether daily-life gait features could provide additional information relative to the laboratory gait features.

Results

Higher depression symptom severity was significantly associated with lower gait cadence of high-performance walking (segments with faster walking speed) over a long-term period in both data sets. The linear regression model with long-term daily-life gait features (R2=0.30) fitted depression scores significantly better (LR test P=.001) than the model with only laboratory gait features (R2=0.06).

Conclusions

This study indicated that the significant links between daily-life walking characteristics and depression symptom severity could be captured by both wearable devices and mobile phones. The daily-life gait patterns could provide additional information for predicting depression symptom severity relative to laboratory walking. These findings may contribute to developing clinical tools to remotely monitor mental health in real-world settings.
An Exploratory Study into the Accessibility of Telementalhealth: A Qualitative Study from Australia. (Preprint)
Authors: Surjatin Faisha , Robinson Nicole , McIntosh Jennifer Gaye
Published: August 2022

BACKGROUND

In March 2020, the World Health Organisation (WHO) declared the COVID-19 virus to be a pandemic. This led to a rapid shift to remote mental health care services using information and communication technologies to help control the spread of the virus. From the beginning of the pandemic up until February 2021, 49.5 million telehealth consultations were made in Australia - an increase from 6.1% in March 2020 to 20% in February 2021.

OBJECTIVE

The objective of this study was to evaluate the accessibility of telementalhealth and identify unique challenges and facilitators to using telehealth for mental health consultations during the COVID-19 pandemic from the clinician and clinic staff’s point-of-view. This will inform research to improve accessibility of telementalhealth.

METHODS

All staff at a busy suite of mental health clinics The Turner Clinics, Monash University Melbourne Australia, were invited to be interviewed about their experience of delivering mental health services using telehealth during the pandemic including perceptions of patients’ experience of using telementalhealth. A thematic analysis was conducted on transcripts of semi-structured interviews to explore their experiences including what they felt were barriers and facilitators to accessibility to telementalhealth consultations.

RESULTS

Interviews were conducted with a range of health care providers (neuropsychologists, clinical and provisional psychologists, and administrative staff) who had been directed involved in telehealth consultations at the Turner Clinics as the primary option for conducting appointments. The inductive analysis of the interview transcripts identified five themes: 1) physical and psychiatric morbidity, 2) client setting and privacy, 3) distance and time, 4) technology, and 5) policies, processes and procedures. Numerous barriers and facilitators to telementalhealth accessibility were identified within these themes.

CONCLUSIONS

The delivery of mental health care services is likely to adopt a hybrid model even after the end of the COVID-19 pandemic. In order to improve the accessibility of telementalhealth, infrastructure should support this to facilitate accessibility for people who are unable to attend mental health consultations physically, but also enable access for those who benefit from face-to-face consultations. These should be addressed with the creation of telehealth-centred procedures at clinics, clinical and public policy changes, and technological solutions.

CLINICALTRIAL

Not a trial.
Applicable Smart City Strategies for a Smart Sustainable City to Ensure Energy Efficiency and Renewable Energy Integration: Casablanca Case Study
Authors: ROCHDANE Hanane , ECHATIBI Salma
Published: August 2022

A Smart city is essentially expected to diminish the utilization of assets and upgrade efficiencies. In practically any region, effectiveness brings about energy saving, diminished energy force, supportable monetary turn of events, upgraded usefulness, a safeguarded climate, and in particular, participation with the environmental change fight. In spite of the fact that financial plan, innovation, and the necessary framework are significant imperatives for helpless urban areas to accomplish shrewd and economical city objectives, the advantages of brilliant urban areas are numerous for helpless urban areas contrasted with creating and created urban areas. Helpless urban areas accomplish worked on living conditions, security, wellbeing, financial turn of events, administration, and personal satisfaction as well as accomplishing supportable energy objectives, and this study tries to distinguish those shrewd sustainable power and energy production systems that are monetarily achievable and in fact relevant in helpless urban communities. Renewable energies are a sustainable, unlimited, and decarbonized solution to address future energy challenges. In this context, Morocco has considerable lead vantage to position itself on this promising market. Furthermore, renewable energies have been highlighted as a key strategic source for the country’s green growth. Morocco has adopted the renewable energy path through a strategy targeted at the development of solar, wind, and hydroelectric power to boost its energy policy by adapting it to the challenges posed by today’s world. Nowadays, Morocco is facing a challenge to reach 52% by 2030 of its total renewable energy capacity, which will exceed 42% by the end of 20221
Sports Law, Its Various Issue in Iran and the World
Authors: Kiani Mohammad Saeid , Nazari Leila , Shahbazpour Leila
Published: August 2022

Background and Aim: The purpose of this study is to study the rights of sports in Iran and the world, its history in Iran. The study of the factors of sports rights in the Constitution of the Islamic Republic of Iran and the world.Methodology: The methodology of this paper is a review study and studying the conditions governing the community as well as reviewing the constitution of Iran and referring to legal texts and sports rights. The scholar has found findings from the 19th century onwards through the review of the fatwa of the Shiite authorities and the examination of the past history of sport and the consideration of the rights of sport in Iran and the world since the 19th century.Findings: Sports rights are one of the branches of law science that examines events in sports. In general, it is possible to say that the purpose of the sporting events is all the crimes committed by athletes, teachers, trainers, spectators and sports event managers, and even sports equipment manufacturers and manufacturers, and the subject matter These incidents can be health and life and property, dignity and dignity and other legal rights of individuals who are in the same range of sports, the quantitative and qualitative scope of the above issues clearly reveals the importance of this field. Conclusion: Today, sport and education with multiple goals of physical and mental self-improvement are considered as integral parts of societies. The need for professional sport is a complex and sometimes risky engagement in sporting activities associated with adverse events and consequences. Meanwhile, the criminal liability of sports events is one of the important issues that are considered during the exercise of sports law.
Asimilando la tradición: Miguel Fisac y la ermita de San Pedro
Authors: Díaz del Campo Martín-Mantero Ramón V.
Published: August 2022

Miguel Fisac Serna (Daimiel 1913-Madrid 2006) fue una de las figuras más relevantes del panorama artístico español del siglo XX. Su trayectoria ha sido ampliamente estudiada como corresponde a una figura tan relevante, pero algunos aspectos de su obra han despertado más interés que otros. En el presente texto se tiene como objetivo poner en valor uno de sus proyectos más desconocidos, pero a la vez más sugerentes: una pequeña ermita construida en Almagro (Ciudad Real), edificio realizado en la década de los ochenta donde un arquitecto de renombre internacional construyó una antigua ermita con un marcado carácter popular. Los lenguajes vernáculos se mezclan con soluciones modernas en una ermita levantada casi sin medios económicos y con una fuerte involucración de la comunidad vecinal.
El arte sacro y su comunicación objetual
Authors: Camacho Cardona Mario
Published: August 2022

En el objeto de arte se plasman los rasgos que evocan las esencias de los modos de ser de los individuos socializados en un momento sociocultural determinado; dichas esencias son captadas por el artista de manera intuitiva-perceptiva y las plasma en la obra de arte, estableciendo una comunicación con base en un lenguaje objetual-artístico por medio de perceptos —emociones, afectos y conocimientos— que serán comprendidos por los espectadores de manera intuitiva y mental a posteriori, generándose así lenguajes de comunicación artística. En la religión católica, el padre dominico Couturier entre otros miembros del clero lucharon para conciliar las ideas del arte religioso con las corrientes artísticas del siglo XX, actualizando la expresión religiosa-artística como también el nuevo carácter arquitectónico, respetando las esencias religiosas católicas.
“Si sonríes a un edificio, el edificio te sonreirá de vuelta”: Prólogo a una historia de las emociones desde la arquitectura modernista
Authors: Lozoya Johanna
Published: August 2022

Desde la teoría de los afectos, del nuevo materialismo y de la antropología simétrica, se propone una historia de las emociones de y desde la arquitectura racionalista (modernista), en términos de una historia de la experiencia subjetiva espacial imaginada por tribus de arquitectos, en cuanto tribus de modernos. Para ello se han seleccionado los relatos con dimensión histórica de los sociólogos Richard Sennet y Nigel Thrift, de la historiadora Barbara H. Rosenwein y de la antropóloga Albena Yaneva. Se plantea en términos metodológicos la liberación de una lógica binaria (cuerpo/mente, humano/no-humano, natural/social) en la interpretación afectivo-emocional del espacio y la espacialidad arquitectónica, y se reflexiona sobre los conceptos “representación” y “más-allá de la representación” en modelos construccionistas que asocian arquitectura, emociones y espacio. Se introducen las categorías “híbridos” y “emotiotopias” y se reflexiona brevemente sobre los retos metodológicos que conlleva la necesidad de liberar a categorías como cuerpo, espacio y edificio, de ontologías antropológicas y sociológicas asimétricas que son comunes, cuando de espacialidad arquitectónica se trata, en las actuales historias de las emociones (y/o perspectiva histórico-afectiva). Por tal motivo, se propone una historia de las emociones desde la arquitectura contemporánea —en términos de una aproximación histórico-antropológica de creencias y prácticas del mundo arquitectónico— como una historia de/sobre híbridos y emotiotopias.