bluuebunny/crossref_metadata_2025 huggingface dataset:
Note on control for hybrid stochastic systems by intermittent feedback rooted in discrete observations of state and mode with delays
Authors: Feng Lichao , Li Dongxue , Zhang Chunyan , Yang Yanmei
Published: December 2023

For a hybrid stochastic system, most existing feedback controllers need to observe modes at continuous times, which is feasible when the system's mode is observable and does not incur any cost. However, in most cases, the mode is not readily apparent, and identifying it always incurs a certain expense. Therefore, in order to reduce control costs, when designing a feedback controller, both the state and the mode should be observed at discrete moments. This paper introduces an intermittent feedback controller for stabilizing an unstable hybrid stochastic system through discrete delayed observations of state and mode. By utilizing M-matrix theory, intermittent control approach, and the comparison principle, we propose sufficient conditions for the stabilization theory of hybrid stochastic systems. An illustrative example is taken to validate the proposed theory.
Impersonal y viviente. Dos paradigmas para pensar (con) otra racionalidad jurídica
Authors: García López Daniel J.
Published: December 2023

Este trabajo tiene un doble objetivo. En primer lugar, presentar dos paradigmas elaborados por Roberto Esposito y por Eligio Resta para pensar (con) otra racionalidad jurídica: derecho impersonal y derecho viviente. En segundo lugar, situar la genealogía de ambos paradigmas en las reflexiones suscitadas en el primer cuarto del siglo XX con Simone Weil y el debate Hans Kelsen-Eugen Ehrlich. La idea principal es plantear una singularidad jurídica en el interior de la Italian Theory.
La cuestión abierta de las tres P: polarización, populismo y posverdad en perspectiva emotivista
Authors: Rodríguez Sáez Arturo , Robles Morales José Manuel
Published: December 2023

La polarización, los populismos y la posverdad forman tres fenómenos sociopolíticos fundamentales para comprender cómo se está orientando la política en los sistemas demoliberales. La polarización política se suele entender como un proceso dinámico de activación de las divisiones entre dos o más grupos sociales en el transcurso de los debates públicos que puede terminar con una ruptura comunicativa o una comunicación fallida. Si bien los especialistas no coinciden a la hora de definir el populismo, se puede comprender como una forma concreta de construir el pueblo mediante un discurso que contrapone este al anti-pueblo. La posverdad se referiría a una tendencia cultural donde las verdades de hecho sufren una merma en favor de las verdades vivenciadas subjetivamente. Estos fenómenos tienden a ser percibidos por una buena parte de la sociedad y del mundo académico como una amenaza grave para las bases pluralistas y reflexivas de la democracia. Sin embargo, esa consideración está decantada normativamente. Este artículo trata de explorar un marco referencial diferente, el emotivismo, y cómo, desde este ángulo, toman sentido los tres conceptos clave: polarización, populismo y posverdad.
El sadomasoquismo a debate: aproximación al estado de la cuestión en las ciencias sociales y objeciones feministas a los principales argumentos de su discurso
Authors: Delicado Moratalla Lydia
Published: December 2023

Este artículo presenta una investigación conceptual que tiene dos objetivos: aportar una aproximación al estado de la cuestión del debate académico de las ciencias sociales sobre el sadomasoquismo (SM) y detectar y discutir los argumentos más estructurantes de su discurso intelectual. Se realiza una revisión de la literatura académica y se analiza desde la teoría feminista. Se problematiza la idea de que el SM es una sexualidad alternativa a la patriarcal; se estudian las fragilidades del consentimiento como su legitimador; y se objeta a la argumentación que lo sitúa en una categoría ontológica. La conclusión principal de la investigación permite dar cuenta de que el SM está constituido de un elogio a la violencia y a la dominación masculina y de que reproduce los estratos políticos de lo masculino y de lo femenino en la sexualidad.
Con manos de ángel: figuras del cuidado en la obra de Miguel de Unamuno
Authors: Fernández Guerrero Olaya , Ledesma de la Fuente Álvaro
Published: December 2023

La literatura especializada sobre Unamuno ha prestado poca atención a la dimensión del cuidado latente en la obra de este filósofo. El presente estudio ofrece una aportación en ese sentido, para ello parte de los planteamientos éticos contemporáneos relacionados con el cuidado y analiza varios textos de Unamuno a la luz de ese marco teórico. El resultado es una lectura novedosa de su obra donde se identifica la presencia de aspectos vinculados a la eticidad del ser-para-otro, se plasma el ejercicio del cuidado ejercido a través del lenguaje y del tacto, y se profundiza en el alcance ético de la actitud maternal omnipresente en los relatos del bilbaíno.
“Let’s Go,” A Mobile Learning Application for Social Studies Subjects: Prototype of Application Development
Authors: Bekti Aprilia  , Maria Paristiowati  , Muhammad Japar
Published: December 2023

The value of social studies learning for junior high school students in several schools still needs to be higher. One of the factors of low student scores is the need for more variety in learning methods used by teachers, low student motivation, and the use of learning media that could be more optimal. One way to do this is to develop a learning model with engaging learning media. This research aims to develop mobile understanding by integrating artificial intelligence at the evaluation stage. The methodology used in this research is the waterfall approach method with requirements analysis, design, implementation, testing, operation, and maintenance. The mobile learning prototype was tested on media experts and junior high school student respondents. The dimensions of expert assessment are reviewed from media appearance, quality and use of media, navigation, product strength, media interface, product attractiveness, and material delivery in the media. The dimensions of questions for students consist of 4 points: content, interface, feedback and assessment, and personalization. The research results show a mobile application’s results, including a brain gym menu, problem identification, materials, discussion forums, assignment results, and quizzes. The menus presented make it easier for students to learn. The questionnaire results from experts show that the highest average is 5.00, with a standard deviation of 0.00. The questionnaire results from student respondents had the highest average of 49.714, with a standard deviation of 0.169. The results of the scores obtained in the expert and student respondent questionnaires show that mobile learning is acceptable.
Developing and Delivering Staff Training in Technical Services
Authors: Linoski Alexis , Slutskaya Sofia
Published: December 2023

This paper offers two different examples of training in technical services: one in acquisitions and one in cataloging. The acquisitions training was intended to prepare staff for implementing Alma acquisitions and used LibWizard as both a training and an assessment tool. The cataloging training used a learning management system to organize existing and freely available cataloging tutorials into a cataloging curriculum suitable for basic copy cataloging training. Both approaches used a combination of existing tutorials, hands-on practice, assessment, and incorporated local practices and workflows as a part of training. The training methods and tools discussed in this paper can be implemented in different library types and different areas of technical services.
Scaling the Library Resources with Zscaler
Authors: Moorthy Anu , Dietsch Barbara
Published: December 2023

More and more institutions and universities are implementing security measures to prevent wide-spread cyberattacks. When institutions initiate new security applications, the library is often overlooked. Libraries have complex ecosystems where multiple applications and systems converge with user data and online library resources. These ecosystems have various considerations including multi-factor authentication, proxies, multiple virtual private networks (VPNs), knowledgebases, and vendor inconsistencies. Duke University Health recently launched data security software called Zscaler, which prevented on-campus users from accessing the library e-resources. This presentation describes how Duke University Medical Center Library staff discovered the access issue and tested various workarounds to allow patrons to access library e-resources. The discussion covered how staff continue to work with Duke University Health IT security staff and university administration to find resolutions for the complex integration of security software with the library’s online resources.
Making the Mission Possible - Connecting Collaborative and Mission-Driven Research and Publishing with a Wider Audience in the Face of Global Social Challenges
Authors: Bell Simon , Mortimer Julia , Kozaitis Suzanne
Published: December 2023

The social world is rapidly changing with the development of new technologies, challenges to expertise and evidence-based knowledge, the effects of climate change, continued poverty and inequality, and the recent need for COVID-19 recovery. Tackling social challenges has been at the heart of Bristol University Press (BUP) from the 1996 inception of Policy Press, its imprint, to becoming the first university press to sign on to the United Nations Sustainable Development Goals (SDGs) Publishers Compact in 2021. Additionally, a forthcoming strategy refresh at the University of Bristol will emphasize civic engagement and social responsibility using the SDGs to monitor impact across their education, research, and civic missions. This session presented the story of BUP’s strategy for cross-collaboration with the University of Bristol to address global social challenges and make meaningful and impactful contributions to real-world problems. A key initiative is the development of BUP’s new Open Access Global Social Challenges Journal, which seeks to decolonize participation in and access to truly global research in the social sciences while maintaining an ongoing commitment to promoting equality, diversity, and social justice.Copyright © 2022 Simon Bell, Julia Mortimer, and Suzanne Kozaitis. CC-BY-NC 4.0
Launch of the NASIG Model Digital Preservation Policy
Authors: Staines Heather , Tavernier Willa Liburd , Wickham Abeni , Enoch Todd
Published: December 2023

Digital preservation is a significant issue if scholarship is to remain available to future users. All organizations involved in scholarly production and dissemination have a role to play. Champions are needed to raise awareness and engage stakeholders. To help, the NASIG Digital Preservation Committee has developed a Model Digital Preservation Policy. This tool is designed to help you measure, grow, and publicize your organization’s commitment to preserving its scholarship. It includes advice on identifying and taking first steps, more advanced options and activities, and opportunities to share and refine professional experiences.
HEURISTIC-ASSISTED ADAPTIVE HYBRID DEEP LEARNING MODEL WITH FEATURE SELECTION FOR EPILEPSY DETECTION USING EEG SIGNALS
Authors: Bhanja Nilankar , Dhara Sanjib Kumar , Khampariya Prabodh
Published: December 2023

The word epilepsy is related to a neurological disease occurred by abnormalities of brain neurons. Timely detection of epilepsy is helpful for patients to decrease the mortality rate. To detect seizures, the Encephalogram (EEG) signals are analyzed based on monitoring the conditions of patients, and seizures can be detected from the EEG signal at appropriate times. The manual detection from the EEG signal requires more time for detecting the seizures and also it needs domain knowledge. The miss detection is eliminated by improving the classification performance in automatic epilepsy detection. Nowadays, deep learning models have not been greatly harnessed in the detection of epileptic seizures due to inappropriate descriptions of time-domain signals and sub-optimal classifier design. The aforementioned issues are combated by the novel Adaptive Hybrid Deep Learning (AHDL) approaches for epilepsy detection using EEG signals. Initially, the required EEG signal is collected from benchmark datasets. The collected signals are subjected to a signal decomposition phase that is accomplished by five levels of decomposition using Dual-Tree Complex Wavelet Transform (DTCWT), where the parameters are tuned by Improved Probability-based Coyote Optimization Algorithm (IP-COA). Further, the decomposed signal is given for feature extraction, where it divides the signal into two phases. In the first phase, the first feature set is obtained by using One-Dimensional Convolutional Neural Network (1DCNN), whereas in the second phase, the proposed model utilizes Auto Encoder (AE) to provide the second feature set. These resultant features are getting fused and the optimal feature selection process is found, where the features are obtained optimally by the IP-COA. Finally, epilepsy detection is accomplished with the aid of proposed AHDL with both Radial Basis-Recurrent Neural Networks (RB-RNN), where the hyperparameters are optimized using IP-COA. Thus, the experimental results illustrate that the suggested model enhances the detection and classification rate.
Environmental Impact of Chitosan Production from Black Soldier Flies Using Life Cycle Assessment
Authors: Riofrio Ariel , Baykara Haci
Published: December 2023

The plastic market is under constant pressure to find viable options to replace petroleum-based polymers. Sustainability has become one crucial parameter when assessing new products or alternatives. Biopolymers are a potential replacement for synthetic plastics because they come from renewable resources. Chitin is the second most abundant biopolymer found in nature, and chitosan is the deacetylated product from chitin. Chitosan has many applications that make it an exciting option for the future. In this study, the environmental impact of the production of chitosan from Black Soldier Flies has been assessed considering a techno-environmental perspective. Three processes were evaluated in the production of chitosan from the insect with variations in the amount of reagent used from an optimization perspective. The optimized process, called the recycled process, showed a significant reduction of the environmental indicator across the 18 categories assessed. Using ReCiPe Midpoint H and SimaPro software, the global warming indicator for this process was calculated among other impact categories. One kilogram of chitosan from Black Soldier Flies emitted 7.69 kg CO2 eq. The higher contributor to the major categories was the use of sodium hydroxide in the deproteinization and deacetylation step. Furthermore, the raw material cost for the chitosan produced from the insects is about $10, which situates this option as equal to chitosan produced from other raw materials, shrimp, or crab shells.
The Degradation Rate of Bio Microbeads Derived from Cellulose and Impregnated with Moringa Leaf Flavonoids Extract
Authors: Silviana Silviana , Jannah Tina Raihatul
Published: December 2023

Microbeads are primary microplastics made from synthetic polymers and are widely applied in cosmetics and personal care products. This wide application led to an increase in microbead production in 2020 from 2.3 billion USD to 3.5 billion USD in the global market, and the growth is directly proportional to the waste generated. Microbeads cannot be filtered by sewage treatment because of their small size, and materials made of synthetic polymers are difficult to degrade by the environment. It is possible to use bacterial cellulose (BC) as a raw material for the production of microbeads because of its physical features and its capacity to break down in the environment. In this review, the best method used for BC synthesis is mechanical fragmentation and drying using ambient pressure drying. BC had also impregnated using Moringa leaf extract to improve its physical properties and usability. After the BC microbeads have been produced, BC degradation analysis can be solved using mechanical degradation. Furthermore, the degradation kinetics of BC microbeads can be determined using the Ekenstam equation, surface degradation kinetics, and elementary reactions (zero, first, second, and third-order equations). The kinetic model of BC microbead degradation will be obtained based on the highest linear regression equation.
Studying the Effects of Annealing on the Mechanical Properties and Microstructure of Ultrasonic Vibration Welds
Authors: Trung Pham Quang , Khanh Bui Duy , Qui Dao Duy
Published: December 2023

The impact of heat treatment on the mechanical characteristics and microstructure of an ultrasonic vibration metal inert gas (MIG) weld is examined in this study. The findings show that the heat treatment method has a significant influence on the mechanical characteristics and structure of the welding specimens. The annealing will increase the grains’ size, thereby reducing the hardness and increasing the ductility of the joint. Due to the impact of ultrasonic during welding, the microstructure in fusion zone of both annealed and non-annealed specimens showed small and fine grain structure (with the grain size being measured at less than 40µm). The result also demonstrates that during annealing, the carbon tended to diffuse from the area of high density to the region of low density, resulting in a reduction in hardness compared to the initial sample. Also, it was discovered that elements that lower weld strength (such as the irregularity of the grain structure and the dendritic structure produced by metal crystallization) significantly decreased.
Study on the Effects of Thermal Shaping for 316L Heat Exchange System of Submersible Vehicle on Fatigue Life
Authors: Hsu Ching Yu , Chiang Chia Chin , Chen Ya Hui
Published: December 2023

In this paper present the effects of 316L steel in the environment of repeated heat load, and the impact of the thermal load on fatigue life. Using thermal fatigue experiments and ABAQUS software, rain flow counting method is used to simplify the strain cycle spectrum of stress load. The Coffin-Manson nonlinear empirical equation was established based on thermal fatigue experiments, and the fatigue life estimation was completed in accordance with the Miner damage accumulation rule and FE-SAFE fatigue software. The test rods were respectively placed at room temperature and heated at 250°C for water cooling for tensile testing. Fatigue tests were performed with 5 strain parameters (0.8%, 0.7%, 0.6%, 0.5% and 0.4%). ABAQUS and FE-SAFE software used to study 316L testing rod fatigue life verification analysis. A composite heat exchange system model made of 316L was designed for the case study. It is found that the fatigue life after heating is reduced by 35% to 12% from the experimental results and numerical simulation calculation. Therefore, when the 316L steel is subjected to thermal fatigue, the fatigue life will be reduced. The research results can provide a reference for the design of heat exchangers using 316 steel in various fields.
Prediction of Tool Wear in Fine Blanking Punch with PVD Coating with TiCN for JIS.SKH51 High Speed Tool Steel Using Archard Wear Model
Authors: Phabsimma Monrudee , Panich Sansot
Published: December 2023

The aim of this study is predict tool wear in the fine-blanking process using a tribometer tester with ASTM G99-17 standard. Then, the result of wear volume and tool life were confirmed with finite element simulation and experiment. The punch material used in fine blanking process was selected to be hight speed steel JIS.SKH51 with surface coating thickness 4 µm of TiCN, the work piece material was used as hot-rolled steel JIS.SPHD P/O, with a thickness of 8 mm. The experimented and simulated results were found that the pressure, and sliding velocity were increase in term of linear curve with slope K = 2.09x10-6 and K = 2.07x10-6 ,respectively, and the hardness of material was increase in term of power at 1.983 and slope of K = 2.14 x10-6. These three factors were effect to the wear volume and tool life, simultaneously, the summation of three factors will average as K = 2.10 x10-6. From comparison of the applied wear equation model with tribology tester the simulated and experimented results were similarly equal with 0.05 by significance at 95% reliability confident. The resulted were precisely confirmed according to the previous research.
Preliminary Investigation on Mechanical Properties of Hollow Glass Spheres
Authors: Sankaran Revathy , Show Pau Loke
Published: December 2023

Hollow glass microspheres (HGM) have been employed in a wide range of applications such as thermal insulating coatings for construction and transportation applications and for acoustic insulation coatings. As such, it is expected for the HGM to exhibit an extremely high pressure tolerance in order to endure the harsh environment. In this present study, an effort has been made to investigate the mechanical properties of hollow glass microsphere. The glass sphere with diameters between 5-30 µm, 50-90 µm and 90-125 µm were used for this investigation. This study's objectives are to investigate the strength of HGM and gain an in-depth understanding of the mechanical characteristics of the sintered spheres.
LVI and CAI Analysis of Woven Carbon Fiber Reinforced Composite Laminates with Different Stacking Sequence
Authors: Anuse Vaibhav Somaji , Shankar Krishnapillai , Velmurugan Ramachandran , Ha Sung Kyu
Published: December 2023

The study investigates LVI testing on woven carbon fiber-reinforced composite laminates at three different energy levels and assesses the specimens for their compressive strengths. X-ray CT scans are used to study the damaged envelopes, which allows better insights into the damage progression and failure mechanisms of the composite. The study investigates how post-impact damage propagation is influenced by alterations in impact energy and stacking orientation. The findings demonstrated that several variables, such as the characteristics of the constituent materials, the stacking order, laminate thickness, and ply orientations, had an impact on the CAI strength of the composite laminate. These findings highlight the importance of considering multiple factors when designing composite materials that can withstand impact loading and maintain their structural integrity. Even in specimens showing barely perceptible surface damage, a considerable drop in compressive strength is seen after the LVI testing. When specimens are struck with 25 J of energy, the compressive strength reduction reached a maximum value of 15.68%. In CAI testing, it is typical for sub-laminates to buckle near the impact-induced damage zone, resulting in failure. The magnitude of impact damage area can significantly affect the CAI strength, as the damaged area may create a stress concentration that can lead to buckling or other types of failure. Therefore, it is important to consider the impact energy and damage size when evaluating the CAI strength of composite materials.
Cooling Effect on Nano Eutectoid Phase Formation of Hypereutectic Zn-Al Alloy
Authors: Hu Anita , Hu Henry , Wei Xingyuan , Nie Xueyuan
Published: December 2023

To understand the nano phase formation, cooling experiments of a hypereutectic Zn-Al alloy containing 6 wt% of Al are carried out under two different cooling rates of 0.04 and 10.00 °C/s. The applied cooling rates significantly influence the phase change behavior of the investigated alloy. The liquidus temperature (TN) for the nucleation of the primary phase decreases from 390.3 to 382.9 °C, and the undercooling increases from 0.7 to 8.1 °C, as the cooling rate rises from 0.04 to 10 °C/s. The eutectic and eutectoid temperatures decrease from 381.5, 277.7 to 375.6 and 267.6 °C, respectively, when the cooling rate increases from 0.04 to 10.00 °C/s. The SEM and EDS analyses reveal that the solidified alloy contains the primary γ-ZnAl phase, the eutectic β-Zn phase, and the eutectoid α-Al and eutectoid β-Zn phases. The fast phase change and transformation caused by rapid cooling results in the formation of nano eutectoid phases and fine microstructure.
Development of a Joint Concept for Producing Dissimilar Joints Using a 3D Printing-Supported Technique
Authors: Almeida Leitão Carlos Miguel , Leal Rui M. , Pereira Miguel A. Reis , Essacalalo Luís F. , Galvão Ivan
Published: December 2023

The joining of metals and polymer-based materials has a very high interest for many industrial sectors, as it allows to achieve components combining the specific characteristics of each material class. Additive manufacturing technologies could boost the production of these joints, allowing the controlled deposition of a polymeric material over the metal substrate. The present research is aimed to study the feasibility of a joint concept that can be used to produce aluminium/polymer-based material joints through a 3D printing-supported technique. The innovative joint concept, which is based on an interlocking mechanism promoted by a deposited pin, was compared to two conventional concepts. The innovative joint concept allows the production of samples with good mechanical behaviour, in which the failure occurs outside the material overlapping zone. This design is very suitable to be tested for the production of dissimilar material joints.
Comparison of Strength Properties of Common Powder Bed Fusion and Stereolithography Materials
Authors: Decker Thierry , Kedziora Slawomir , Museyibov Elvin
Published: December 2023

This paper serves as basis for subsequent studies investigating a potential material and manufacturing method selection for producing lattice structures to be used as energy absorption device, such as in novel wearable protective gear. Four additively manufactured plastics from two additive manufacturing methods are examined in detail. Polyamide 12 specimens produced on two Powder Bed Fusion (PBF) machines are compared against specimens produced on a stereolithography (SLA) printer using a standard and an engineering-grade resin. A comprehensive analysis of their mechanical properties is presented by measuring their densities as well as tensile, fatigue, and impact properties. In addition, Poisson’s ratio of the resin materials is estimated using Digital Image Correlation (DIC).
Fracture Prediction of Aluminum Alloy Sheet AA2024-T3 Using Analytical Stress and Experimental Strain Based Failure Criteria
Authors: Sawangpan Jurarat , Panich Sansot , Wiratchakul Kotchakorn
Published: December 2023

In this work, the fracture prediction of aluminium alloy sheet, grade AA2024-T3 was investigated using the Fracture Forming Limit Curve (FFLC) and Analytical Fracture Forming Limit Stress Curve (FFLSC) as failure criteria. Initially, the FFLC was experimentally achieved by means of the Nakajima Stretch forming test coupled with GOM strain measurement system, providing the Digital Image Correlation (DIC) technique. Subsequently, the analytical FFLSC was plastically computed using experimental FFLC data combination with Swift hardening model and anisotropic Hill’48 yield model for representing anisotropic plastic deformation behaviour on examined sheet. Finally, Fukui stretch drawing and Three point bending tests were conducted both experiment and numerical simulation to evaluate the fracture state and verifying an applicability of obtained FFLC and FFLSC. In the simulation, the ABAQUS 2017 element deletion function was employed for directly implementing the fracture criteria regarding the FFLC and FFLSC. It was concluded that the analytical FFLSC could more realistically predict fracture behaviour better than the FFLC based on strain. In term of percentage error, the analytical FFLSC generated an error less than the FFLC.
Finite Element Analysis on Comparative Hyperelastic Material for CTSIB Foam
Authors: Toobunterng Thaman , Suvanjumrat Chakrit , Prinyakupt Jaroonrut
Published: December 2023

The objective of this research is to investigate the properties of standardized foam materials in clinical balance testing, assuming that the behavior of the foam material is hyperelastic. To simulate the deformation behavior, the finite element method was used in conjunction with the behavior of hyperelastic materials. We perform a value of the properties of materials without the use of destructive compression testing samples. Compression tests were performed on real materials according to standardized test methods that did not cause the destruction of the actual material. The collected data were then used to generate stress-strain relationship curves and compare them with different behavior models of hyperelastic materials using the finite element method. The behavior model of Ogden hyperelastic materials showed the highest similarity to the behavior of foam materials.
Impaired local Vitamin D3 metabolism contributes to IL-36g overproduction in epithelial cells in chronic rhinosinusitis with nasal polyps
Authors: Xiao Q , Wang H , Song J , Qin Z-Y , Pan L , Liao B , Deng Y-K , Ma J , Liu J-X , Hu J , Gao P , Schleimer R P , Liu Z
Published: December 2023

BACKGROUND: Vitamin D (VD) possesses immunomodulatory properties, but its role in chronic rhinosinusitis with nasal polyps (CRSwNP) remains poorly studied. Herein, we aim to explore the regulation and function of VD3 in CRSwNP. METHODS: 25-hydroxyvitamin D3 (25VD3) levels in serum and tissue lysates were detected by ELISA. The expression of VD receptor (VDR) and cytochrome P450 family 27 subfamily B member 1 (CYP27B1), the enzyme that converts 25VD3 to the active 1,25-hydroxyvitamin D3 (1,25VD3), and their expression regulation in human nasal epithelial cells (HNECs) were studied by RT-PCR, western blotting, immunofluorescence, and flow cytometry. RNA sequencing was performed to identify genes regulated by 1,25VD3 in HNECs. HNECs and polyp tissue explants were treated with 1,25VD3, 25VD3, and dexamethasone. RESULTS: 25VD3 levels in serum and nasal tissue lysates were decreased in patients with eosinophilic and noneosinophilic CRSwNP than control subjects. The expression of VDR and CYP27B1 were reduced in eosinophilic and noneosinophilic CRSwNP, particularly in nasal epithelial cells. VDR and CYP27B1 expression in HNECs were downregulated by interferon γ and poly (I:C). Polyp-derived epithelial cells demonstrated an impaired ability to convert 25VD3 to 1,25VD3 than control tissues. 1,25VD3 and 25VD3 suppressed IL-36γ production in HNECs and polyp tissues, and the effect of 25VD3 was abolished by siCYP27B1 treatment. Tissue 25VD3 levels negatively correlated with IL-36γ expression and neutrophilic inflammation in CRSwNP. CONCLUSION: Reduced systemic 25VD3 level, local 1,25VD3 generation and VDR expression result in impaired VD3 signaling activation in nasal epithelial cells, thereby exaggerating IL-36γ production and neutrophilic inflammation in CRSwNP.
Effectiveness of an amino acid beverage formulation in diarrhea-predominant irritable bowel syndrome: A pragmatic real-world study
Authors: Niles Samantha E , Blazy Phil , Cheuvront Samuel N , Kenefick Robert W , Vidyasagar Sadasivan , Smith Adam B , Fawkes Neil , Denman William
Published: December 2023

BACKGROUND

Amino-acid based medical foods have shown promise in alleviating symptoms of drug induced gastrointestinal side effects; particularly, diarrhea-predominant symptoms. Irritable bowel syndrome (IBS) is a gastrointestinal disorder that affects up to 9% of people globally, with diarrhea predominant IBS (IBS-D) being the most prevalent subtype. Further trials are needed to explore potential added benefits when integrated into standard care for IBS-D.

AIM

To assess the effectiveness of an amino acid-based medical food as an adjunct to standard of care for adults with IBS-D.

METHODS

This is a pragmatic, real world, open label, single arm study comparing a 2-week baseline assessment to a 2-week intervention period. One hundred adults, aged 18 to 65 years, with IBS-D, according to Rome IV criteria, were enrolled after completing a 2-week baseline assessment period and received a 2-week supply of an amino acid based medical food which was consumed at home twice daily on top of their standard of care. The primary outcome was an assessment of tolerability after 2-weeks of consumption, while secondary outcomes included changes in stool consistency (Bristol Stool Form Scale), severity of abdominal pain & discomfort, symptoms of urgency, Global Improvement Survey (GIS), and the IBS severity scoring system (IBS-SSS).

RESULTS

The test product was well-tolerated as each participant successfully completed the full 14-day trial, and there were no instances of dropouts or discontinuation of the study product reported. Forty percent of participants achieved a 50% or more reduction in the number of days with type 6-7 bowel movements (IBS-D stool consistency responders). Fifty-three percent of participants achieved a clinically meaningful reduction of 30% in mean weekly pain scores, and 55% experienced the same for mean weekly discomfort scores (IBS-D pain and discomfort responders). Participants experienced a mean -109.4 (95% confidence interval: -130.1, -88.8) point reduction on the IBS-SSS and 52% experienced a minimally clinically important difference of > 95 points. An IBS-SSS category shift from severe to moderate or mild occurred in 69% of participants. For functional symptoms, 76% of participants reported symptom relief on the GIS.

CONCLUSION

The amino acid-based medical food was well-tolerated, when added to the standard of care, and demonstrated improvements in both overall IBS symptom severity and IBS-D symptoms within just 2 wk.
Das Politische in Sama Maanis Roman Žižek in Teheran
Authors: Šetinc Matej
Published: December 2023

In the article “The Political in Sam Maani’s Novel Žižek in Tehran” we examine how the political enters into the poetics of Maani’s novel. We are particularly interested in the roles played by the satire, subversiveness and form of this postmodern-modern text. Can the political within such a literary work turn back to the recipient and reach back to the extra-literary reality without turning literature into agitprop? Our aim is to observe whether the essential elements that establish a human as a political being, the field of “being-with” (Mit-sein) or of action in the space of “being-with” (Mit-sein), or, according to Bakhtin, the event of co-being (sobytie), are present in the novel. 
Our study shows that all the protagonists as subjects are reduced, or split, there are no clear identities, and the narrative is fragmented. Many metatexts in the form of parentheses or additions further disrupt the unity of time and space. The video clips mentioned in the novel should also be considered as an integral part of the text. Furthermore, Tehran, which is the name given to the country in the novel, should not be understood as simply referring to Iran. In the novel Teheran bears the characteristics of other countries and the historical traits of their dictatorships. It is precisely the deconstruction of reality and the departure from realism that make it possible to literarize the political without fearing that the novel can be read as a univocal allegorical description of reality in Iran. The narrator turns to the reader and establishes a dialogue with him. In this way the recipient, i.e. the real reader, becomes the other and the field of dialogue between them becomes politically functional, since by establishing meaning and by logically constructing the narrative the reader enters as the addressed in the field of “being with” and participates by taking positions. Reading becomes an act of the political from the space of the aesthetic. However, since the novel is about one of the greatest possible traumas of humanity and is also written as a kind of poetic psychoanalysis, the process of reception and the construction of meaning of this text is at the same time a kind of healing, as is also implied in the novel’s conclusion.
Implementation of a Croatian Teaching Abroad Programme in the Republic of Serbia
Authors: Ordulj Antonia , Bušljeta Kardum Rona , Uršal Margareta , Andreis Lea
Published: December 2023

The first comprehensive programme in the Croatian language in the Republic of Serbia started in 2002, and the status of the Croatian community as a national minority was recognized, but teaching took place in very challenging circumstances, considering the numerous obstacles in hiring teachers, difficulties with textbooks, the decreasing number of Croats and the perception of the typologically related Serbian language as the mother tongue among Croats. The aim of this research is to get an insight into the experiences of teachers who work within the Croatian Teaching Abroad (CTA) programme in the Republic of Serbia. Only teachers from the Republic of Croatia selected by the Ministry of Science and Education participated in the research. The research was conducted through an anonymous survey that examined: 1) teacher education for work through the analysis of specific and general competencies and the suitability of available textbooks in the Croatian language, 2) the teachers’ ability to deliver content related to the cultural and historical heritage of Croatia and 3) the teachers’ qualifications for teaching Croatian as a heritage language. The results show that: 1) the teachers need additional intercultural competencies that they did not acquire during formal education, 2) the existing textbooks are not fully suitable for teaching language and literature, 3) the teachers need further training and practice in teaching the Croatian language before teaching Croatian abroad, especially in the area of acquiring Croatian as a heritage language, which is primarily due to the lack of programmes for the education of teachers of Croatian as a foreign or heritage language at the formal level. Moreover, the teachers note the problem of students’ prior knowledge and motivation, as well as that of differentiating between the Croatian and Serbian languages, as great challenges.
SOCIEDADE DIGITAL E CIDADANIA
Authors: Vilela Márcia Alves Medeiros , Silva Ana Walquíria Souza da , Ribeiro Priscilla Eustáquio de Oliveira , Oliveira Ricardo Furtado de , Santos Sonia Araújo dos
Published: December 2023

O uso das Tecnologias de Informação e Comunicação (TICs) nas atividades educacionais tornou-se uma poderosa ferramenta pedagógica para as instituições de ensino, e os professores têm à sua disposição diversos recursos digitais capazes de transformar e reconfigurar suas metodologias de ensino, tendo agora, além da sala de aula presencial, a internet como novo espaço educacional, frequentado por usuários do mundo inteiro, e onde direitos precisam ser respeitados, assim como deveres precisam ser cumpridos.  É mediante este novo contexto que o presente estudo, desenvolvido por meio de pesquisa bibliográfica, discutiu sobre a temática tecnologia, educação, cidadania e os riscos aos quais professores e alunos estão expostos neste espaço online, com o objetivo de identificar quais práticas digitais a escola adota para garantir a segurança digital da sua comunidade acadêmica. A pesquisa revelou que os riscos cibernéticos são numerosos e podem ser evitados, mas não eliminados, devido ao constante avanço tecnológico. Porém, se as instituições de ensino trabalhar em parceria com profissionais especializados na área de Tecnologias de Informação e Comunicação, acerca de práticas digitais que minimizem as armadilhas cibernéticas, que acontecem de forma generalizada, a tríade professor, aluno e família pode se tornar multiplicadora do uso seguro e consciente das redes digitais, uma vez que o conhecimento daí advindo pode ser compartilhado com aqueles usuários que, ainda, estão excluídos da cidadania e sociedade digitais.
A APRENDIZAGEM COLABORATIVA E A TAXONOMIA DE BLOOM
Authors: Silva Eliane Rozario da , Vilalva Ester Aparecida de Mei Mello , Rodrigues Fábio Feitosa , Pereira João Alves , Castro Vander Aparecido de
Published: December 2023

Este paper teve como metodologia a revisão bibliográfica realizada a partir do referencial teórico abordado na disciplina e realizado a partir de um esboço de um Projeto para alunos do Ensino Médio.  O projeto proposto associa a Aprendizagem Colaborativa e a Taxonomia de Bloom com escopo de enfatizar a melhoria do ensino de adolescente no Ensino Médio que queira se aprofundar no tema da Segunda Guerra Mundial e se preparar para a realização do ENEM. Além de demonstrar que a aprendizagem colaborativa é reflexo do que ocorre atualmente na sociedade globalizada, onde verifica-se a interligação entre os métodos de comunicação, também ressalta a importância de conectar os conhecimentos através de vivências formando uma aprendizagem em colaboração. Adicionalmente, mostra a relevância dos verbos da Taxonomia de Bloom que tem como finalidade avaliar se foram atingidos os objetivos da aprendizagem. A utilização de alguns verbos determina o teor da aprendizagem, e constata-se que muitas vezes não é necessário a implantação de todos os verbos, a depender do objetivo que se busca.
Un plan articulador para eventos adversos. Neutralizando los efectos psicológicos para mejorar el desempeño de equipos asistenciales
Authors: Vega Gomez Katherine Piedad , García Cabrera Hernan Efilio , Luján Johnson Gladys Lola
Published: December 2023

La COVID-19 ha expuesto la precariedad de los sistemas de salud para enfrentar crisis sanitarias globales. Además de los efectos físicos, la pandemia ha tenido un impacto psicológico significativo tanto en la población en general como en el personal médico, lo que podría comprometer la respuesta y la recuperación posterior. Para reducir los riesgos psicosociales, es fundamental implementar un plan que contemple una comunicación efectiva, la formación adecuada en la gestión de crisis, así como un sólido apoyo social y psicológico. Solo un enfoque integral permitirá enfrentar adecuadamente los desafíos actuales y futuros en el ámbito de la salud. Es por eso que este libro presenta una propuesta de gestión operativa de riesgos ante efectos psicológicos por COVID-19 e incluso para escenarios más adversos, que permita mejorar el desempeño del personal de primera línea.
Fomentando la conciencia legal: socialización del Código de la Niñez y Adolescencia en la Unidad Educativa Nueva Concordia, Ecuador
Authors: Moreira Obando Michael Alexander , Torres Basurto Junior Alejandro , Montaño Hurtado Juan Eliecer , López Martha Cecilia
Published: December 2023

Herramienta de investigación, con la cual se pretende indagar sobre el cumplimiento de los deberes y obligaciones de las niños y niñas; análisis que se lo realizó mediante la implementación de encuestas en donde se dieron observaciones, para este estudio se ha tomado en cuenta a los estudiantes de decimo de educación básica de la unidad Educativa Nueva Concordia, mediante la información que se recopiló se aportará para cumplir con los objetivos de estudio. El desarrollo del siguiente análisis de caso, se lo estructuró por fundamentación teórica; en la cual se va a implementar representaciones generales, que sustentan el proyecto, la metodología describe cómo se va realizar el estudio de la propuesta de análisis, una vez realizado se alcanzara una interpretación de resultados; con los datos recopilados se recurre analizarlos e interpretarlos mediante tablas y gráficos estadísticos. Se planteará a las autoridades de la institución algunas recomendaciones, con la finalidad de contribuir al mejoramiento de las relaciones y conocimientos del código de la niñez y adolescencia con los estudiantes, para que exista un ambiente de respeto, paz y armonía esperando pueda servir como referente para otras instituciones que buscan la misma finalidad con los estudiantes.
PENERAPAN BAGI HASIL DALAM PEMBIAYAAN MUDHARABAH DI BANK MUAMALAT TULUNGAGUNG
Authors: Bagus Ahmadi  , Arif Nur'aini
Published: December 2023

The banking system has a strategic position as a support for the national economy. In Indonesia there are two banking systems, namely conventional banking systems and Islamic banking. In general, saving in conventional and sharia banking is no different, because both banks are required to follow general banking techniques. However, if analyzed more deeply, there are fundamental differences between the two. The first difference lies in the contract and the second difference in the reward. In banking products for profit-sharing contracts there are two, namely the Mudhorobah contract and the Musyarakah contract. However, mudhorobah contracts are rarely used for transactions in all Islamic banks.
Of the products available at Islamic banks, one of them is mudhorobah contract financing in Islamic banking. This study has two problem formulations, namely how the terms and mechanisms of mudharabah financing at Bank Muamalat and how the implementation of mudharabah financing at Bank Muamalat. The purpose of this study is the first, to find out the mechanism and mudharabah transactions at Bank Muamalat Tulungagung, second to find out the implementation of mudharabah financing at Bank Muamalat Tulungagung. By using qualitative research methods, the first type of research, location, second source of data, third data analysis and data collection procedures, fourth technique, fifth data validation, and the sixth research stage.
Keywords: application and mudharabah contract
La relación sobre la importancia de incorporar la sostenibilidad y la responsabilidad social en el desarrollo de competencias docentes
Authors: Litardo John Tobar , Ruiz Sandra Martinez , Martínez Laura Sudario , Wong Cristian Rodríguez
Published: December 2023

La investigación abordó varias cuestiones críticas relacionadas con la integración de la sostenibilidad y la responsabilidad social en el desarrollo de competencias docentes en el contexto de la educación superior. Mediante un enfoque cuantitativo y correlacional, se encuestó a 148 profesores universitarios de Guayaquil y para el análisis de los datos se utilizó el software SPSS V21. Los resultados mostraron correlaciones significativas y positivas entre las habilidades docentes y las dimensiones identificadas: formación de habilidades sostenibles, enfoque multidisciplinario, Desarrollar el Pensamiento Crítico y las Habilidades de Resolución de Problemas, y compromiso con la comunidad y el medio ambiente. Aunque se encontró una relación inversa para la integración del programa ODS, este resultado resalta la necesidad de realizar un análisis más detallado. El modelo resultante destacó el papel esencial del desarrollo del pensamiento crítico y las habilidades de resolución de problemas para mejorar las habilidades de enseñanza. Estos hallazgos resaltan la importancia de integrar la sostenibilidad y la responsabilidad social en la formación docente, lo que puede informar el diseño de programas de desarrollo profesional destinados a promover una enseñanza más eficaz y sostenible.
MENGEJAR PEMULIHAN: SEBUAH UPAYA MENCAPAI PENYEMBUHAN DALAM KELUARGA BATAK KRISTEN
Authors: Purba Hans Hennery
Published: December 2023

antaranya mengarah pada konflik dan hubungan yang kompleks sehingga memengaruhi banyak pihak secara negatif. Dalam tulisan ini, penulis mengamati budaya dalam konteks suku Batak yang menjadi salah satu akar permasalahan dalam konflik keluarga. Tulisan ini mencoba untuk melihat pengaruh dari budaya yang dirasa selama ini memiliki peran signifikan dalam memunculkan konflik antar pihak dan menjadi rintangan untuk mencapai pemulihan hubungan. Metode yang digunakan adalah studi kasus dalam proses konseling pastoral. Hasil penelitian menunjukkan bahwa konflik dalam keluarga suku Batak dapat ditengahi dengan pemahaman yang komprehensif terhadap suku Batak. Dengan pemahaman yang khas, maka konflik dapat diselesaikan dengan baik.