bluuebunny/crossref_metadata_2025 huggingface dataset:
Improving the Traction and Energy Characteristics of Self-Contained Locomotives Through the Use of Modular Design of the Traction System Elements
Authors: Talahadze Temur , Grebennikov Nikolay , Bol'shih Ivan
Published: December 2023

Purpose: The priority direction of strategic programs for the development of railway transport is the design and introduction into operation of new rolling stock, which is characterized by high technical and economic indicators. In this regard, the goal is to formulate scientifically based technical solutions to reduce the costs of production, maintenance and repair of traction rolling stock and improve its traction and energy characteristics. Methods: To achieve the stated goal, the following methods have been applied: structural analysis; statistical processing of large arrays of experimental data; computer simulation; theory of locomotive traction. Results: Priority directions for improving traction rolling stock have been identified. A set of scientifically based technical solutions has been developed to improve the traction and energy characteristics of selfcontained locomotives, which may allow the transition to a single platform for diesel and electric locomotives. As a result, the reduction in costs for the production, maintenance and repair of traction rolling stock and an improvement in the traction and energy characteristics of locomotives will be achieved. Practical significance: Economic effect obtained due to reducing the costs of production, maintenance and repair of traction rolling stock and the consumption of fuel and energy resources for train traction.
Mediación Sociosanitaria Intercultural
Authors: Segura Garcia Maria Teresa , Alaoui Benabderrahman Nivine , Salas Antolinez Agustín
Published: December 2023

La Comarca del Poniente es región receptora de población migrante con diversidad lingüística y sociocultural. Esta diversidad en el ámbito sanitario constituye una barrera de comunicación con los pacientes migrantes que determina peores resultados en salud y de equidad en la accesibilidad a la atención sanitaria. Proyecto de Mediación Sociosanitaria Intercultural (MSSI): Con el fin de garantizar una comunicación eficaz entre el paciente y el profesional, en el año 2020 se crea, en Hospital Universitario Poniente, el proyecto MSSI, cuyo objetivo es implantar un modelo de atención con perspectiva intercultural. Durante el periodo comprendido entre 2020 y 2022, la demanda en mediación proviene mayoritariamente del área asistencial, siendo en consultas externas donde más actuaciones se han llevado a cabo: 2020 (63%), 2021 (61,6 %), 2022 (68%); y las más demandadas son presenciales 2020 (86%), 2021 (94%), 2022 (95%). Respecto a la perspectiva de género, el sexo femenino fue el que más actuaciones necesitó: 2020 (67%), 2021 (67%), aunque en 2022 se equilibró la necesidad (54%). Los resultados confirman la necesidad y pertinencia de MSSI en el Servicio de Salud Público de Andalucía para mejorar la accesibilidad equitativa a la atención sanitaria en centros de similares características.
Természetvédelmi szabályozás révén kialakított, természetközeli állapotú élőhelyek felhagyott síkvidéki építőanyag-bányákban
Authors: Sipos Ferenc , Kovács Éva , Vajda Zoltán
Published: December 2023

Természetvédelmi szabályozással irányított rekultivációjú építőanyag-bányákban spontán kialakult, magas természeti értékű élőhelyek ökológiai állapotának felmérési eredményeit mutatjuk be. Egyik vizsgálati helyszínünk a dunai főmederhez csatlakozó, természetes mellékágat utánzó, sekély vizű felhagyott kavicsbányameder Szalkszentmártonnál, ami egyebek között a tompa folyamkagyló (Unio crassus), a szivárványos ökle (Rhodeus amarus) és az európai hód (Castor fiber) élőhelyévé vált. A másik: egy természetes szikes tavi és szikes pusztai élőhelymozaikot utánzó, felhagyott homokbánya Balástyánál, amelyben a nem egészen két évtized alatt betelepült növényfajok száma meghaladja a 200-at. Mindkét területen csak a felhagyással kialakuló környezeti körülményeket szabta meg a természetvédelmi államigazgatási beavatkozás. Célunk annak bemutatása, hogy az építőanyag-bányászat – a jelenlegi általános gyakorlattól eltérően – megfelelő helyválasztással és rekultivációs módszerrel olyan, magas természeti értékű vizes élőhelyek előállítására is képes lenne, melyek trendszerű fogyatkozása súlyos ökológiai probléma a Kárpát-medencei kultúrtájban.
Los abordajes de las adicciones como un campo de convergencia entre estudios sobre religión, espiritualidad, salud y drogas
Authors: Scuro Juan
Published: December 2023

Se muestra una revisión de investigaciones sobre adicciones. Se consideró especialmente la producción de literatura latinoamericana, donde las adicciones son abordadas desde perspectivas teórico-metodológicas que incluyen análisis provenientes de: ciencias sociales de la religión; etnografías sobre drogas; antropología médica. Particularmente, se profundiza en los modelos de tratamiento de las adicciones que denomino neopentecostal y neochamánico. Estos modelos forman parte de un sistema de cuidados entendido en sentido amplio, donde las dimensiones religioso-espirituales se hacen expresamente presentes. Se muestran sus principales características según se desprende de la bibliografía revisada y se plantea una mirada al tema desde Uruguay. El estudio de las imbricaciones y convergencias de lo religioso y la salud en el caso de las adicciones es un campo fértil para el desarrollo de perspectivas teóricas y analíticas. Los debates sobre laicidad y secularización encuentran aquí una particular base empírica para problematizar.
Hiato tecnológico entre pequenas empresas do Brasil e de países europeus
Authors: Silva Marcelo Duarte , Botelho Marisa dos Reis Azevedo
Published: December 2023

A discussão sobre hiato tecnológico parte da ideia de que empresas e países com diferentes níveis de desenvolvimento tecnológico atingem resultados econômicos distintos, em termos de nível de renda, ou de competitividade. O objetivo deste trabalho é investigar a existência de hiato tecnológico entre as pequenas empresas do Brasil e países Europeus selecionados, com base nas pesquisas de inovação Community Innovation Survey e Pesquisa de Inovação Tecnológica, para 2014. Por meio de metodologia baseada no conceito de “distância euclidiana”, foi desenvolvido o Índice de Inovação e Índice de Eficiência do Esforço Inovativo, ambos a partir de dados de esforço e resultado inovativo. Os principais resultados mostram que, com referência aos pares europeus, pequenas empresas brasileiras não apenas têm elevado hiato no Índice de Inovação, como também o tem no indicador de eficiência do esforço inovativo.
Digitalização, expectativas e dinamismo industrial
Authors: Coutinho Luciano Galvão
Published: December 2023

Este artigo propõe um mapa conceitual, teórico-analítico, com objetivo de compreender o processo contemporâneo de digitalização das empresas industriais nas economias em desenvolvimento. Analisa a pertinência da hipótese schumpeteriana de que o progresso técnico na era digital possa impulsionar um 4º ciclo longo de dinamismo industrial ou 4ª Revolução Industrial. Busca, também, iluminar complementaridade desta hipótese com a visão keynesiana sobre o cálculo empresarial do retorno dos investimentos em inovação, sob incerteza, expectativas e convenções mutantes, ressaltando o papel chave do impulso empreendedor (animal spirits) no desenvolvimento capitalista. Analisa os crescentes desafios que a era digital impõe aos países em desenvolvimento com base, respectivamente, nas visões estruturalista e institucionalista de Furtado e Abramovitz. Finalmente, alerta para o risco de aprofundamento das heterogeneidades, desigualdades e, no limite, exclusão desses países e suas empresas defasadas da 4ª RI.
Ecossistema de inovação e digitalização
Authors: Laplane Mariano , Borghi Roberto Alexandre Zanchetta , Torracca Julia
Published: December 2023

O artigo tem por objetivo discutir o papel do ecossistema de inovação como fator que contribui para a adoção de gerações mais avançadas de tecnologias digitais nas empresas. Com base na literatura sobre gestão estratégica de empresas e economia da inovação de inspiração neoschumpeteriana, o artigo avalia se a participação em um ecossistema de inovação intensivo em recursos para o desenvolvimento de tecnologias digitais estimula o processo de digitalização das empresas. A discussão baseia-se na análise dos resultados de um questionário aplicado em 2020 a empresas localizadas na região metropolitana de Campinas, algumas das quais vinculadas à Unicamp, e a empresas de outras regiões do Brasil. O exercício econométrico comprova que a participação das empresas em ecossistemas de inovação promove a adoção de estágios mais avançados de digitalização para setores econômicos específicos.
Hubungan antara Strategi Koping dengan Distres Psikologi pada Perawat di Masa Pandemi COVID-19
Authors: Qanita Zalfa , Cahyanti Ika Yuniar
Published: December 2023

Pandemi COVID-19 telah memberikan dampak yang signifikan pada sektor kesehatan, terutama bagi para tenaga kesehatan, seperti perawat. Banyak perawat yang mengalami distres psikologi selama pandemi. Distres psikologi itu sendiri erat kaitannya dengan bagaimana seseorang melakukan usaha koping. Oleh karena itu, penelitian ini bertujuan untuk melihat bagaimana hubungan antara strategi koping (problem-focused, emotion-focused, dan dysfunctional coping) dengan distres psikologi pada perawat di masa pandemi COVID-19. Partisipan dalam penelitian kuantitatif ini merupakan 48 perawat yang sedang atau pernah bekerja dalam menangani kasus pasien COVID-19. Alat ukur yang digunakan yaitu Brief-COPE untuk mengukur strategi koping dan General Health Questionnaire-12 untuk mengukur distres psikologi. Hasil analisis uji korelasi menunjukkan bahwa tidak terdapat hubungan yang signifikan antara strategi koping dan distres psikologi pada perawat di masa pandemi COVID-19.
Konsumsi Program Survival Show dan Pengaruhnya dalam Third Language Vocabulary Acquisition Bahasa Korea
Authors: Meidina R Irvanti Sufa , Cahyono Rudi
Published: December 2023

Penelitian ini merupakan studi pendahuluan yang bertujuan untuk melihat pengaruh konsumsi survival show terhadap third language vocabulary acquisition dalam bahasa Korea. Penelitian ini menggunakan desain penelitian one-way pre-test post-test dengan jumlah partisipan sebanyak 10 orang (N=10) dengan rentang usia 18-24 tahun yang belajar bahasa Korea sebagai bahasa ketiga secara otodidak. Episode 5 dari “Produce 101 Season 2” merupakan program survival show yang dipergunakan dalam penelitian ini dan tes perbendaharaan kata dalam bahasa Korea dipergunakan untuk mengukur tingkat third language vocabulary acquisition. Kemudian, data di analisis dengan menggunakan teknik Wilcoxon. Hasil penelitian menunjukkan bahwa program survival show dapat meningkatkan third language vocabulary acquisition bahasa Korea partisipan penelitian (memiliki pengaruh yang signifikan (Z=-4,089; p=0,001). Hasil tersebut menunjukkan bahwa acara dalam format survival show ini dapat menjadi media untuk meningkatkan third language vocabulary acquisition bahasa Korea secara otodidak yang efektif.
A conformação da medida de segurança ao sistema de saúde mental brasileiro pela reforma estrutural
Authors: Silva Nunes Leonardo , De Abreu Costa André , Nascimento Oliveira Josilene
Published: December 2023

A medida de segurança no Sistema de Justiça Criminal, como regra, implica internação compulsória em manicômios judiciários, o que viola os direitos fundamentais, visto o descompasso com a Lei no 10.216/2001, que trata do modelo assistencial em saúde mental; com a Convenção das Nações Unidas sobre os Direitos das Pessoas com Deficiência e com a Lei no 13.146/2015, que institui o Estatuto da Pessoa com deficiência, portanto com a legislação brasileira no âmbito da abordagem social da deficiência. Sob a vertente metodológica jurídico-sociológica, analisa-se, com o enfoque dos direitos fundamentais, a possibilidade de conformação da medida de segurança ao sistema de saúde mental por meio da reforma estrutural e da via processual, para verificar se a promoção de uma mudança possibilita a efetivação dos direitos fundamentais desses sujeitos. Pelo método dedutivo, busca-se refletir sobre a sistemática das medidas de segurança como forma de responsabilização penal do infrator com transtorno mental.
Ficus tikoua, a new record for Thailand, with associated lectotypifications
Authors:   Thailand Natural History Museum, National Science Museum, Khlong 5, Khlong Luang, Pathum Thani, Thailand, Chantarasuwan Bhanumas , Supong Wisoot ,   Thailand Natural History Museum, National Science Museum, Khlong 5, Khlong Luang, Pathum Thani, Thailand, Duangjai Sutee ,   Department of Forest Biology, Faculty of Forestry, Kasetsart University, Bangkok 10900, Thailand
Published: December 2023

Ficus tikoua, a member of the subgenus Sycomosus, is reported for the first time in Thailand. This creeping shrub was discovered in a dwarf forest at high elevation (1,400–1,500 m asl) on the top of Phu Luang Mountain in Phu Luang Wildlife Sanctuary, Loei Province. A key to the Thailand species of Ficus subgenus Sycomorus is given. A description based on Thai collections is provided. We lectotypify the names F. tikoua and F. nigrescens.
Effect of Zinc Supplementation to Diluent Boar Semen on Sperm Characteristics and Activity of Antioxidant Enzymes
Authors: Slyvchuk Oksana , Shtapenko Oksana , Yaremchuk Iryna , Kornyat Serhiy , Dzen Yevhen
Published: December 2023

Background. Zinc is essential for male reproductive function as it is necessary for spermatozoa maturation, capacitation, acrosome reaction, and fertilization. It has been established that the use of chelates compounds of metals with amino acids, nucleotides, peptides, and carbohydrates is not only more effective but also economically justified.
Objective. The aim of this study was to evaluate and compare the effect of different concentrations of Zn glutamic amino acid chelate (ZnGlu) on boar spermatozoa motility, viability parameters, and prooxidant-antioxidant homeostasis during in vitro incubation.
Methods. Freshly ejaculated boar semen, after the addition of "Ecosperm" diluent, was divided into groups: a control group and three experimental groups. Zinc glutamate was supplemented to the experimental samples at concentrations of 1.0, 2.0, and 5.0 µg/ml, respectively. Semen samples were stored at 18 °C for 4 days. Every 24 hours, sperm motility and viability and the antioxidant status were assessed by the level of diene con­jugates (DC), concentration of malondialdehydere (MDA), and the activities of catalase and superoxide dismutase.
Results. It was observed that boar sperm motility decreased with the extension of storage time, while the addition of 2.0 and 5.0 µg ZnGlu significantly improved sperm total motility and the percentage of vitality spermatozoa during 48–96 hours of incubation. Our studies also demonstrate that ZnGlu possess a protective effect in alleviating oxidative stress in boar sperm in vitro. The addition of ZnGlu significantly reduced the content of MDA and DC in ejaculate samples in all experimental groups during incubation, compared to the control group. Moreover, the activity of superoxide dismutase and catalase increased after adding ZnGlu to the boar semen, especially at concentrations of 2.0 and 5.0 mg/ml (P < 0.05).
Conclusions. These data demonstrate that the supplementation of zinc glutamate enhances the antioxidant defence system of sperm and improves quality of boar semen in vitro.
Fin de l’élimination des poussins mâles d’un jour : le choix du sexage in ovo
Authors: REHAULT-GODBERT Sophie , BOURIN Marie , GAUTRON Joël , QUENTIN Maxime
Published: December 2023

Une problématique majeure de la filière avicole est l’absence de valorisation des frères des poules pondeuses, du fait de leur faible rendement en viande. Ce constat, qui questionne l’éthique de la production, concerne 50 millions de poussins mâles en France et 7,5 milliards dans le monde, ces animaux étant jusqu’à récemment, éliminés après sexage et tri à l’éclosion. Cette prise de conscience, largement médiatisée ces dernières années, a conduit à la publication d’un décret, le 5 février 2022, interdisant la mise à mort des mâles des lignées de l’espèce Gallus gallus destinées à la production des œufs de consommation. Trois alternatives ont été proposées depuis les premières réflexions sur le sujet : 1) élever les frères de pondeuses et identifier des marchés de valorisation, 2) créer de nouveaux croisements génétiques entre souches « Chair » et souches « Ponte » où les descendantes femelles seraient valorisées pour les œufs et les descendants mâles pour leur viande (souches « mixtes »), et 3) développer des outils de sexage in ovo (ou ovosexage) pour détecter puis éliminer les œufs contenant un embryon mâle avant éclosion. Cette dernière approche est la seule viable techniquement et économiquement parlant, et utilisable par la filière actuellement. Elle réunit de nombreux atouts, en termes de faisabilité pour la mise en œuvre dans les couvoirs, et d’acceptabilité à la fois par le consommateur, le citoyen et les professionnels. Cette revue fait le point sur le contexte socio-économique et les techniques d’ovosexage actuellement disponibles, tout en introduisant quelques repères physiologiques d’embryologie aviaire qui permettent de mieux comprendre les contraintes associées au développement de techniques à des stades précoces de développement.
Classification des carcasses de porc dans l’Union européenne : aperçu historique et défis d’harmonisation
Authors: DAUMAS Gérard
Published: December 2023

La filière porcine a pour finalité essentielle de produire de la viande commercialisable. Depuis un demi-siècle, l’exigence majeure en termes de composition des carcasses concerne la teneur en viande maigre. Cette teneur est prédite dans les abattoirs par des méthodes de classement autorisées au niveau européen. La définition de cette teneur a changé en 2018 et les États membres l’adoptent progressivement. De nouveaux modèles d’appareils, utilisant les ultrasons, la visionique ou l’induction magnétique, sont apparus sur le marché, permettant pour certains d’accéder à de nouvelles mesures. Le développement de la production de mâles entiers a modifié la composition du cheptel dans beaucoup de pays. Les objectifs de cette synthèse sont de faciliter la compréhension des modalités de classement dans l’UE, de faire le point sur les méthodes autorisées et leur précision, d’anticiper les prochains changements et d’émettre quelques recommandations pour une bonne utilisation des résultats individuels de classement. Au 1er janvier 2023, 126 méthodes de classement, utilisant une vingtaine d’appareils, relevant de quatre technologies, étaient autorisées dans l’UE. Seuls huit pays avaient des méthodes prédisant le nouveau critère de référence. Les technologies à induction magnétique et ultrasons sont en moyenne plus précises que celles utilisant la réflectance et la visionique. Les méthodes automatiques sont également plus précises. Néanmoins, une très grande variabilité existe selon les méthodes, l’erreur de prédiction étant comprise entre 1,1 et 2,5 points de pourcentage de muscle. Bien que la règlementation européenne ait permis d’atteindre un certain degré d’harmonisation du classement entre États membres, des biais entachent la comparabilité des résultats.
Search for Novel Phases in Y-Ba-Cu-O Family
Authors: Djurek Danijel
Published: December 2023

In order to search possible residual minor phases in Y-Ba-Cu-O family, powdered mixtures of Y2O3 + BaCO3 + CuO and, independently, superconducting compound YBa2Cu3O7-x have been treated in evacuated cells and elevated temperatures.YBa2Cu3O7-x was reduced to YBa2Cu3O5 by use of the special home designed Taconis-Knudsen vacuum device. A subsequent doping by oxygen converts produced insulator YBa2Cu3O5 to semiconductor or metal YBa2Cu3O5+x (0<x<0.3). In addition to YBa2Cu3O5, 0.05 volume percent of the minor delafossite phase Y2Cu2O4 was being spotted in the powder mixture 1/2 Y2O3 + 2BaCO3+6Cu2O, heated up to 818 °C in an inert gas atmosphere. An attempt to prepare the insulating bulk delafossite samples was successful, and subsequent doping by oxygen produces novel metallic phases.
Cascaded Three-Phase Multilevel Inverter with Minimal Components for Power System Applications
Authors: Tackie Samuel Nii , Ozerdem Ozgur Cemal , Mohammed Salim Tsowa , Hesri Ali Sidi Abubaker
Published: December 2023

This paper proposes a new cascaded three-phase multilevel inverter based on a cascaded submultilevel and single-phase H-bridge structure. The voltage source of the traditional single-phase H-bridge is replaced with the proposed cascaded submultilevel. Cascading two basic units forms the submultilevel unit. The basic and submultilevel units generate positive voltage only hence the need for an H-bridge to generate both polarities of load voltage. Five algorithms of source voltage are proposed and the optimal algorithm selected to generate the peak load voltage and output levels. The proposed three-phase cascaded multilevel inverter generates 31-level of load voltage. The per-phase component distribution of the proffered inverter are twelve power switches, four dc sources and twelve driver circuits accordingly. Principal merits of the proposed 31-level inverter are high quality load waveforms, production of high levels of load voltage utilizing reduced component quantity, simple cascaded layout, decreased inverter area, minimal inverter cost, minimum inverter losses and utilizing lower rated switches. Also, the proposed topology is highly suited for employment in PV-DVR and other power systems. To validate these advantages of the proposed multilevel inverter, contrastive analysis of the proposed inverter and existing topologies are studied. Finally, the functionality of the proposed inverter is substantiated by simulation in PSCAD/ EMTDC software.
Pioneering the Future of Industrial Development: Harnessing Membrane Separation Breakthroughs to Propel CO2 Extraction from Natural Gas into a Sustainable Era
Authors: JOHNSON NNADIKWE , DOZIE EWELIKE ASTERIUS , Momoh Abdulazeez Adeyemi, , Azunna Onuabuchi
Published: December 2023

Natural Gas (NG) processing is a prominent industrial separation process. Among the available techniques, the innovative membrane process shows potential for efficient removal of impurities, including carbon dioxide (CO2). This study focuses on utilizing breakthroughs in membrane separation to drive sustainable CO2 extraction from natural gas. Through comprehensive research and analysis, we explore the effectiveness and feasibility of membrane-based systems in removing CO2 impurities from NG, thus promoting greener and more sustainable industrial practices. Our findings underscore the transformative nature of membrane separation technology, presenting new possibilities for a more environmentally-friendly and sustainable approach to CO2 extraction from natural gas.Natural Gas (NG) processing utilizes various techniques for impurity removal, with the membrane process emerging as a promising option for efficient carbon dioxide (CO2) extraction. This research proposes the integration of a simple mathematical model into ASPEN HYSYS to design a membrane system for CO2/CH4 separation. The study also investigates parameter sensitivities by altering operating conditions, such as feed composition and pressure, as well as membrane properties, including selectivity. By analyzing these variables, we aim to optimize the performance and efficiency of the membrane system, facilitating the sustainable extraction of CO2 from NG. The findings contribute to advancing the design and operation of membrane-based processes for CO2 separation, paving the way for greener and more sustainable industrial practices. In addition, this study explores various configurations for optimizing the design of the membrane system, including single-stage with and without recycling as well as double-stage configurations. The investigation demonstrates that methane recovery can be enhanced through the recycling of the permeate stream and by implementing a double stage membrane system. These findings highlight the potential for improving the efficiency and performance of the membrane system, enabling higher methane recovery rates. By considering different configurations, this research contributes to the development of more effective and sustainable CO2 extraction processes from natural gas.
Recent Light on the Developmental Perspectives of Regeneration in Annelids
Authors: Bandyopadhyay Srinwanti , Munshi Chayan
Published: December 2023

Annelids are well-known for their ability to regenerate. The morphological development in terms of regeneration physiology, involves several cellular factors which play crucial roles in the developmental phenomena. The physiological process of regeneration involves critical biomechanical processes which is effectively regulated by the cellular factors. In today’s biological research, the fundamental analysis of regeneration is necessary for the scientific assessment of cellular-biomechanical advancements, which eventually helps to develop adequate insight in the biomedical research in regenerative sciences. In this review we have elucidated the recent research on explaining the developmental physiology of regeneration in annelids.
Hydrogen and Vitamin C Combination Therapy: A Novel Method of Radioprotection
Authors: Miyakawa Michiko , Zhang Songbai. , Behnan Jinan , Morganti Claudia , Ito Keisuke , Isaksn Pauline , Miyakawa Ayako , Uhlen Per
Published: December 2023

Radiation therapy is employed in treating various cancer types. However, depending on the type and stage of cancer, its benefits can be limited, and it may cause serious side effects that detrimentally affect the quality of life (QOL) for the patient. Preventing the side effects of radiation therapy can enhance the response to cancer treatment and improve the patient’s QOL. Independently, vitamin C and hydrogen have demonstrated potential in reducing the side effects of anticancer drugs and radiation therapy. Furthermore, both have been postulated to possess direct anticancer properties. However, the effects of their combined therapy remain underexplored. This study investigates the hypothesis that combining vitamin C and hydrogen efficiently prevents radiation-induced injuries.

Survival rates were investigated in cancer cell lines (MDA-MB231 and GL261) and normal cells (HUVEC) treated with hydrogen, vitamin C and irradiation. Apoptosis was assessed using the FLICA test, and EMT gene expression was elucidated via the qPCR technique.

In the normal cell line, the introduction of vitamin C and hydrogen to the culture medium boosted survival rates, exhibiting a radioprotective effect upon irradiation. In contrast, cancer cells showed a decreased survival rate with the introduction of vitamin C and hydrogen, which was further diminished with irradiation. Treated cancer cells showed signs of apoptosis. Caspase activity in viable cells was reduced by the combination treatment with vitamin C and hydrogen. Additionally, glioblastoma cells treated with this combination showed reduced EMT gene expression.

This study reveals that a combined therapy of hydrogen and vitamin C offers radioprotective effects on normal cells and exerts direct anticancer effects on cancer cells, while also amplifying the anticancer effects of radiation. Importantly, this combined therapy attenuated the radiation-induced EMT signature in the GL261 murine glioma cell line, suggesting potential in diminishing treatment resistance and tumor invasion.
FOSL1’s Diverse Roles in Glioma/Glioma Stem Cells and Tu-morigenesis: A Comprehensive Review
Authors: Khedri Azam , Guo Shanchun , Ramar Vanajothi , Hudson BreAnna , Liu Mingli
Published: December 2023

This review centers on the pivotal role of the oncoprotein FOSL1, within the dimeric AP-1 transcription factor consisting of FOS-related elements. FOSL1 emerges as a key regulator governing invasion and metastatic dissemination, therefore making it a promising target for therapeutic intervention in cancer patients. The review provides a comprehensive survey of the regulatory mechanisms that exert influence over FOSL1. These encompass a spectrum of transcriptional and post-translational modifications. Notably, we unveiled the intricate involvement of diverse non-coding RNAs, specifically microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), in the modulation of FOSL1 expression through targeted interactions with its mRNA transcripts. Furthermore, an exploration into the functional dimensions of FOSL1 unfolds, encompassing apoptosis, proliferation, and migration. This investigation is accompanied by a thorough examination of the elaborate signaling pathways that underpin these multifaced roles. Additionally, emphasis is placed on the role of FOSL1 in orchestrating the stimulation of various cytokines, including TGF-beta, and the initiation of IL-6 and VEGF production in tumor-associated macrophages (TAMs) that transverse into the tumor microenvironment. A distinct focus is dedicated to appraising the prognostic implications associated with FOSL1. Finally, insights emerge into the evolving roles of FOSL1 in the context of mechanisms governing resistance and dependency on targeted therapeutic modalities.
Understanding the Bactericidal and Virucidal Capacity of Potassium Peroxymonosulfate in Varied Environments and Its Utilization in Eradicating Germs on Diverse Surfaces and Clothing
Authors: Punyadarsaniya Darsaniya , Kunanusont Nutnaree , Takehara Kazuaki , Ruenphet And Sakchai
Published: December 2023

The study evaluated potassium peroxymonosulfate (PPMS) efficacy against rifampicin-resistant Salmonella Infantis (rif-SI), Escherichia coli (E. coli), Salmonella Infantis (SI), Newcastle disease virus (NDV) and avian influenza virus (AIV). The assessment encompassed varied concentrations, organic material conditions, and exposure durations to comprehensively evaluate PPMS efficacy. Moreover, PPMS’s efficacy was tested on diverse carrier surfaces and clothing to evaluate its bactericidal and virucidal potential. At the recommended concentrations (1X), PPMS effectively inactivated all pathogens within 5 sec, except for NDV, which required 30 sec in the presence of organic materials. At 0.5X, PPMS successfully inactivated E. coli, AIV and NDV within 5 sec in the absence of organic material. However, rif-SI and SI necessitated 30 sec for inactivation. Most pathogens were inactivated within 30 sec, with the exception for AIV, which was inactivated within 5 sec. PPMS effectively eliminated rif-SI on all carriers within 30 sec. Moreover, at both concentrations, PPMS successfully inactivated AIV on all carriers within 30 sec, except on stainless steel at 0.5X. Furthermore, PPMS at both concentrations required 5 and 30 sec, respectively, to inactivate AIV on the rayon sheet. Therefore, due to its demonstrated efficacy against a wide range of pathogens across diverse surfaces, PPMS emerges as a crucial alternative disinfectant significantly enhancing biosecurity on and around chicken farms. found in and around animal farms, slaughterhouses, and hospitals.
C-S and Strongly C-S Orthogonal Matrices
Authors: Liu Xiaoji , Liu Ying , Jin Hongwei
Published: December 2023

In this paper, we present a new concept of the generalized core orthogonality (called the C-S orthogonality) for two generalized core invertible matrices $A$ and $B$. $A$ is said to be C-S orthogonal to $B$ if $A^{\tiny\textcircled{S}}B=0$ and $BA^{\tiny\textcircled{S}}=0$, where $A^{\tiny\textcircled{S}}$ is the generalized core inverse of $A$. The characterizations of C-S orthogonal matries and the C-S additivity are also provided. And the connection between the C-S orthogonality and C-S partial order has been given using their canonical form. Moreover, the concept of the strongly C-S orthogonality is defined and characterized.
The Importance of Complement-Mediated Immune Signaling in Alzheimer’s Disease Pathogenesis
Authors: Batista André Felipe , Khan Khyrul Anam , Papavergi Maria-Tzousi , Lemere Cynthia Ann
Published: December 2023

As an essential component of our innate immune system, the complement system is responsible for our defense against pathogens. The complement cascade has complex roles in the central nervous system (CNS), most of what we know about it stems from its role in brain development. However, in recent years, numerous reports have implicated the classical complement cascade in both brain development and decline. More specifically, complement dysfunction has been implicated in neurodegenerative disorders, such as Alzheimer’s disease (AD), which is the most common form of dementia. Synapse loss is one of the main pathological hallmarks of AD and correlates with memory impairment. Throughout the course of AD progression, synapses are tagged with complement proteins and are consequently removed by microglia which express complement receptors. Notably, astrocytes are also capable of secreting signals that induce the expression of complement proteins in the CNS. Both astrocytes and microglia are implicated in neuroinflammation, another hallmark of AD pathogenesis. In this review, we provide an overview of previously known and newly established roles for the complement cascade in the CNS and we explore how complement interactions with microglia, astrocytes, and other risk factors such as TREM2 and ApoE4, modulate the processes of neurodegeneration in both amyloid and tau models of AD.
Historical Perspectives in the Pedagogy of Anatomy Instruction in Medical and Graduate Education: From Salerno to Montserrat
Authors: Tulp Orien , Sainvil Frantz , Branly Rolando , Wu Hailin , Einstein George
Published: December 2023

Because the including of human anatomy forms the foundation for clinical medicine, it has contributed a pivotal role in medical education for many centuries. Thus with advancements in the science of modern, current day medicine, its continued place in the medical school curriculum deserves careful attention. In an attempt to provide guidance to decision-makers involved in clinical anatomy curriculum development at the medical school level, the Educational Affairs Committee of the American Association of Clinical Anatomists (AACA) developed this document, which defines the contours of a gross anatomy curriculum leading to the M.D. or D.O. degree. The main body of the document sets forth the anatomical concepts as well as the subject matter a student should master prior to graduation from medical school. Gross anatomy dissection is still a crucial topic in graduate and medical school. The nature and content of gross anatomy, which was historically regarded as a core course in the first year of medical education in MBBS, MD, DO, and some PhD and Graduate curricula as well as in other disciplines of selective graduate education and non-allopathic medical programs, have been significantly impacted by emerging challenges in the pedagogy of delivering medical education in the past ten years. A seemingly ever-increasing emphasis on additional modules in molecular biology, emerging pharmacotherapeutics and pathophysiology content have resulted in a condensation and apparent erosion of previously allotted classroom and laboratory hours in the gross anatomy curriculum. In addition, an imposition of financial constraints and a decreasing availability of sufficient cadaver donations to support gross anatomy dissection labs has also occurred in some locations. An innovative clinically focused cadaveric anatomy program is described which has improved the delivery and content retention of medical and graduate students and has become one of the most sought-after modules in the revised clinically oriented curriculum and has been deemed highly relevant to current medical education and graduate studies.
Bridging Gaps in the Standard Model
Authors: Khan Kamil , Ali Haseeb , Nabi Sardar
Published: December 2023

Topological defects such as magnetic monopoles that may have formed during cosmological phase transitions in the early universe. The Kibble mechanisms govern the formation of this defects and their abundance is influenced by the correlation length and the temperature-dependent Higgs mass. The Magnetic monopoles are particularly interested but their excessive production poses the monopole problem which is challenge to the standard model. Many solutions including symmetry breaking patterns and thermal pair production have been proposed to mitigate the monopole problem. Detecting monopoles would offer valuable insights into high-energy physics and the early universe. Detection of (even) a single monopole could revolutionize our current knowledge of the universe.
Infrasonic Sound-Based Obstacle Detection System for the Visually Impaired
Authors: khan kamil , Nabi Sardar
Published: December 2023

Millions of people worldwide experience visual problems nowadays. According to the recent WHO survey, approximately…… million people are blind. They become reliant on others because of this issue. According to recent studies, 108 various techniques are utilized to help the moment of people who are visually impaired. In this research we will employ infrasonic sound to improve the ability of blind persons to identify obstacles that comes in its way at the distance ranging from 2 to 3.5 maters. The concept was created by drawing inspiration from a mammal termed certain animals inherent navigational system. The infrasonic detection for the visually impaired people is a complicated procedures ,now we will simply discuss the obstacle finding mechanism in this article. The project uses an Arduino UNO microcontroller, infrasonic sensors, a buzzer powered by 5 volts , a vibrator, burning Arduino cable and a few connecting wires. On a cap that the blind people will wear all of this arrangement will be placed. High frequency sound is emitted by the infrasonic emitter picked up by the infrasonic receiver after reflecting off of the obstruction and then transmitted to the processor for additional required activity in the form of sound and vibration.
Pengukuran Indeks Pembangunan Literasi Masyarakat (IPLM) Kota Salatiga sebagai Dasar Penyusunan Program Pengembangan dan Pembinaan Perpustakaan
Authors: Warsito Budi , Rachman Hakim Arief , Fatmawati Endang
Published: December 2023

The development of public literacy in Indonesia is very dependent on several aspects of people’s reading skills. In determining program development policies and indicators of success, periodic reviews and benchmarks are required. The formulation of the Community Literacy Development Index measurement needs to be done in Salatiga City. The CLDI research aims to determine the value of CLDI in Salatiga City, such as the condition of all types of libraries, both from the aspect of library distribution, collections, library staff, to users in Salatiga City. CLDI measurements were carried out using a census approach. From the results of the research, the score for the Salatiga City CLDI in 2023 was 81.21%. It can be concluded that the score of 81.21% is in the interval between 80 and 90 so the CLDI of Salatiga City in 2023 is included in the high level.
Preservasi Digital Warisan Budaya: Sebuah Ulasan
Authors: Dwi Putra Dedy , Sahrul Bahtiar Firma , Nizam Rifqi Ach. , Mardiyanto Verry
Published: December 2023

Digital preservation plays an important role in safeguarding cultural heritage. Along with the development of the times, cultural heritage as a valuableassetcannot be separated from potential threats in the form of damage and loss. Digital preservation is an aspect of opportunity in maintaining the sustainability of cultural heritage values. Through a qualitative approach with the literature study method, this research seeks to provide an overview of aspects of digital preservation in relation to efforts to protect cultural heritage. The results of the study illustrate that digital preservation has strong relevance in terms of protecting cultural heritage values from damage and loss. The involvement of technology in digital preservation results in convenience in efforts to save cultural heritage by representing cultural material in digital formats. Digital preservation has various challenges including technological obsolescence, loss or damage to data, intellectual property rights, preservation costs, metadata and contextual information, skills and expertise, social and ethical considerations, utilization, and various other things according to the context of implementation. A digital preservation strategy that includes aspects of technological environmental conservation for future use and handling of technical limitations is an integral part of overcoming existing challenges. By implementing various strategies and actively participating in the realm of digital preservation activities, the existence of cultural heritage with its noble values can be maintained and gain long-term accessibility for the sustainability of future generations.
CODE SWITCHING IN LONDON LOVE STORY FILM
Authors: Meliani Ni Luh Desi
Published: December 2023

Code switching is one of the topics that go into sociolinguistics study. This term refers to the phenomenon of language switching, either spoken or written, done by bilingual or multilingual people. In its development, code switching often appears in many literary works, one of them is in London Love Story film. London Love Story is an Indonesian movie released in 2016 by Screenplay Films house production. This movie contains code switching of two languages, Indonesian language and English. This research focused on analyzing the types of code switching which appears in this film which performed by the characters. The result in this research shows there are three types of code switching performed in London Love Story film, namely inter-sentential code switching, tag switching, and intra-sentential code switching refers to types of code switching proposed by Poplack (1980). Eleven utterances categorized into inter-sentential code switching, five utterances categorized into tag switching, and eight utterances categorized into intra-sentential code switching types. This phenomenon is influence by the reasons and social factors of code switching.
SEMIOTIC ANALYSIS FOUND ON SELECTED SCENE IN ASUS VIDEO ADVERTISEMENT
Authors: Diantari Ni Putu Ayu , Putri I Gusti Ayu Vina Widiadnya
Published: December 2023

This study aimed to find out the verbal and visual signs used in the ASUS video advertisement and the meaning of those signs. The data source is from ASUS's YouTube in the name of the Asus Vivobook S 14X/16X OLED product. Analysis of verbal and visual signs is part of the semiotic study. The process of collecting data was conducted by observation method, and there were some steps in collecting the data. The collected data were analyzed by the descriptive qualitative method. The data was analyzed verbal and visual signs based on the theory of semiotics by Saussure, cited in Chandler's book (2007). This study analyzes the meaning of signs using the denotative and connotative meaning theory by Barthes (1967), and supported theory of color by Wierzbicka (1996). This study presented the data by using the formal and the informal method, which described the meaning of the verbal and visual signs found in the ASUS advertisement. The more discovered signs are verbal signs than visual signs. This study also found both types of meaning which are, denotative meaning and connotative meanings, were used in all of the data that is in order to convey messages regarding promoting the commercial product, which is ASUS.
SOCIAL DISCRIMINATION: A CASE STUDY OF SOCIAL SUBORDINATION TO BAHASA INDONESIA OF VERNACULAR EASTERN INDONESIAN
Authors: Wijaya Ayudhia Ratna , Rizal Cesar Abdul
Published: December 2023

This research aims to explain the correlation between Bahasa Indonesia’s vernacular variation and the social discrimination experienced by Eastern Indonesian. The researchers apply qualitative-quantitative method. The data were collected from the distributed online questionnaires which were filled by 41 respondents from Eastern Indonesia (East Nusa Tenggara, Sulawesi, Maluku, Papua). The findings show that there is a diglossic phenomenon between standard Bahasa Indonesia (High variety) and Bahasa Indonesia of Vernacular Eastern Indonesia (Low variety). The unique dialectal characteristics of Eastern Indonesian in Bahasa (phonological, lexical, and morphological) raised the issue of linguistic racism and linguistic privilege. Eastern Indonesian speakers of Bahasa are considered as minority speech community who suffered racism and discrimination. They experienced intimidation from people’s undermining impersonation, underestimation, and exclusion from the dominant speech community. They felt ashamed of their vernacular language identity and tend to imitate dominant accents, such as Javanese or Jakartan Indonesian. This is a serious issue that can increase social disparities and conflict among Indonesians. To solve the problem, the researchers suggest that Indonesian government must introduce Bahasa Indonesia’s variation (including morphological, lexical, and phonological variation from all Indonesian region) in the formal education as the best solution to give societies understanding of linguistic tolerance. 
MOOD ANALYSIS OF UTTERANCES IN INDONESIA’S COVID-19 VACCINE ARTICLE IN ONLINE NEWSPAPER
Authors: Putri Rahma Yunita , Laila Malikatul
Published: December 2023

This study examines the MOOD analysis of interpersonal meaning in articles in online newspapers about the covid-19 vaccine in Indonesia. The purpose of this study is to explain the formula of MOOD analysis realized in grammar and to describe the speakers' mood in the application of the MOOD analysis in Indonesia's covid-19 vaccine article from online newspaper. The main focus of this research is on descriptive text articles and MOOD structure. This type of research is descriptive qualitative, the author uses observation documentation as a technique to obtain and measure data. The data were obtained by applying the theory of Gerot and Wignell (1994). The researcher found 259 clauses from six texts which became data taken from various online news sources. In the formula, there are various types such as Subject + Finite (Tense), Subject + Finite (Do), Subject + Finite (Modal), Subject + Finite (Have) and Subject + Finite (To be). The most commonly found category is the use of Finite (Tense). In the mood of the speaker, it is found that the speaker expresses certainty, possibility, uncertainty, obligation and advice. What most of the speakers said was certainty. In the analysis also found several categories of modalities, which after that can be included in the degree of modality, namely high, medium, and low. Because the limitations of this study are in a declarative, all clauses are statements that function to convey information from the author to the reader.
CODE-MIXING FOUND IN SCARLETT WHITENING INSTAGRAM POSTS
Authors: Sagitarini Ni Made Mutiara Deca , Putra I Gde Agoes Caskara Surya
Published: December 2023

This study focused on the code-mixing phenomenon discovered in an Instagram post by Scarlett White. The Instagram post of Scarlett Whitening was recently featured as one of the most popular beauty products in Indonesia. This research seeks to determine the various types of code-mixing in Scarlett Whitening's Instagram posts, as well as the most prevalent types and the reasons why they are used. For the purpose of data analysis, a qualitative descriptive method was employed in this study. Analysis of the data revealed three types of Code-mixing: intrasentential mixing, intra-lexical mixing, and changes in pronunciation. Moreover, code-mixing occurs for three reasons: discussion of a particular subject, interjection, and the desire to clarify the speech content for the interlocutor.