bluuebunny/crossref_metadata_2025 huggingface dataset:
ChemInform Abstract: Synthesis of α‐Sulfanyl‐β‐amino Acid Derivatives by Using Nanocrystalline Magnesium Oxide.
Authors: Kantam M. Lakshmi , Mahendar Koosam , Sreedhar Bojja , Choudary Boyapati M. , Bhargava Suresh K. , Priver Steven H.
Published: October 2010

Nanocrystalline MgO is an effective catalyst for the Mannich‐type reaction of alkyl, aryl, and heterocyclic N‐sulfonyl aldimines with sulfonium salts to afford the title compounds with moderate diastereoselectivities.
ChemInform Abstract: A New Effective Synthesis of Arene Mono‐ and Disulfonyl Chlorides.
Authors: Barbero Margherita , Bazzi Stefano , Cadamuro Silvano , Dughera Stefano , Magistris Claudio , Venturello Paolo
Published: October 2010

The title compounds are prepared by a three‐step sequence.
ChemInform Abstract: Ruthenium‐Catalyzed C—H Bond Functionalizations of 1,2,3‐Triazol‐4‐yl‐Substituted Arenes: Dehydrogenative Couplings versus Direct Arylations.
Authors: Ackermann Lutz , Novak Petr , Vicente Ruben , Pirovano Valentina , Potukuchi Harish K.
Published: October 2010

Regioselective arylation of title substrates (I), (IV) and (VII) is easily achieved with aryl chlorides under conditions A).
ChemInform Abstract: Oxidation of Alkynes Using PdCl2/CuCl2 in PEG as a Recyclable Catalytic System: One‐Pot Synthesis of Quinoxalines.
Authors: Chandrasekhar S. , Reddy N. Kesava , Kumar V. Praveen
Published: October 2010

Internal alkynes are readily oxidized to the corresponding diketones under conditions A).
ChemInform Abstract: Palladium‐Catalyzed Decarboxylative Cross‐Coupling of Alkynyl Carboxylic Acids with Arylboronic Acids.
Authors: Feng Chao , Loh Teck‐Peng
Published: October 2010

A variety of unsymmetrical alkynes (III) is readily prepared by a highly efficient Pd(O‐Ac)2‐catalyzed decarboxylative cross‐coupling of boronic acids (I) with acids (II) in the presence of Ag2O as oxidant.
ChemInform Abstract: Optimization of a Pd‐Catalyzed Intramolecular α‐Arylation Synthesis of Tricyclo‐[7.3.1.02.7]‐trideca‐2,4,6‐trien‐13‐ones.
Authors: Powell Noel A. , Hagen Timothy J. , Ciske Fred L. , Cai Cuiman , Duran Joseph E. , Holsworth Daniel D. , Leonard Daniele , Kennedy Robert M. , Edmunds Jeremy J.
Published: October 2010

Optimized and scalable reaction conditions are developed for the Pd‐catalyzed cyclization of 2‐(2‐halobenzyl)cyclohexanones and related heterocyclic substrates to tricyclic ketones (II) and (IV).
ChemInform Abstract: A 1,3‐Carbonyl Shift in the Platinum‐Catalyzed Aromatization of 2‐Epoxy‐1‐(methoxyalk‐2‐ynyl)benzenes.
Authors: Chaudhuri Rupsha , Das Arindam , Liao Hsin‐Yi , Liu Rai‐Shung
Published: October 2010

The platinum‐catalyzed aromatization of epoxides (I) and (III) is accompanied by a 1,3‐carbonyl shift to afford polysubstituted naphthalenes (II) and (IV), resp., in good yields.
ChemInform Abstract: An Efficient Synthesis of Bioactive Fluorescent Benzylidine Tetralones.
Authors: Kamakshi R. , Latha S. Swarna , Reddy B. S. R.
Published: October 2010

A variety of chalcones (III) and related benzylidene tetralones (V) are synthesized and found to display significant antibacterial activities towards both gram‐positive and gram‐negative bacteria.
ChemInform Abstract: A Tandem Catalytic Approach to Methyleneindenes: Mechanistic Insights into gem‐Dibromoolefin Reactivity.
Authors: Bryan Christopher S. , Lautens Mark
Published: October 2010

The reaction proceeds via tandem intermolecular Suzuki/intramolecular Heck coupling tolerating a wide range of functional groups.
ChemInform Abstract: 1,3,6,8‐Tetrasubstituted Pyrenes: Solution‐Processable Materials for Application in Organic Electronics.
Authors: Sonar Prashant , Soh Mui Siang , Cheng Yuen Hsia , Henssler John T. , Sellinger Alan
Published: October 2010

The star‐shaped conductors are soluble in common organic solvents.The introduction of different (het)aromatic moieties is found to have a substantial influence on their optoelectronic and thermal properties.
ChemInform Abstract: Synthesis of New Heterocyclic Derivatives of 2‐Imino‐2,5‐dihydrofurans and Some of Their Chemical Transformations.
Authors: Avetisyan A. A. , Karapetyan L. V.
Published: October 2010

Title compounds (III) are synthesized by reaction of tertiary α‐keto alcohols (I) with cyanacetic amides (II) and converted to dihydrofuran‐2‐ones (IV), dihydrochlorides and dicyanomethylene derivatives (VI).
ChemInform Abstract: Synthesis of Multisubstituted Furans via Copper‐Catalyzed Intramolecular O‐Vinylation of Ketones with Vinyl Bromides.
Authors: Chen Liqun , Fang Yewen , Zhao Qiwu , Shi Min , Li Chaozhong
Published: October 2010

The title reaction can be applied to the preparation of a broad spectrum of target compounds and benzopyran (XVI).
ChemInform Abstract: Epoxides to α‐Mercapto‐γ‐lactones via Ionic Liquid Promoted Mercaptoacetylative Ring‐Opening—Ring‐Closing Cascade.
Authors: Patel Rajesh , Srivastava Vishnu P. , Yadav Lal Dhar S.
Published: October 2010

Regioselective opening of the epoxide ring in the presence of oxathiolanone (I) produces an intermediate alcohol which undergoes intramolecular translactonization at elevated temperature to yield the synthetically and pharmaceutically important target compounds.
ChemInform Abstract: Direct Catalytic Asymmetric Synthesis of Highly Functionalized Tetronic Acids/Tetrahydro‐isobenzofuran‐1,5‐diones via Combination of Cascade Three‐Component Reductive Alkylations and Michael‐Aldol Reactions.
Authors: Ramachary Dhevalapally B. , Kishor Mamillapalli
Published: October 2010

A practical two‐step synthesis of enantioenriched highly substituted perhydrobenzofuran derivatives (V) and (XI) is presented.
ChemInform Abstract: Synthesis of Dibenzothiophenes and Related Classes of Heterocycles by Using Functionalized Dithiocarbamates.
Authors: Kienle Marcel , Unsinn Andreas , Knochel Paul
Published: October 2010

The cyclization of functionalized dithiocarbamates opens the route to various condensed S‐heterocycles.
ChemInform Abstract: Synthesis of Novel 2‐Thienylimino‐1,3‐thiazolidin‐4‐ones.
Authors: Abdillahi Ismail , Revelant Germain , Datoussaid Yazid , Kirsch Gilbert
Published: October 2010

The title compounds (VII) are prepared from 3‐aminothiophene‐2‐carboxylates using a simple four‐step procedure.
ChemInform Abstract: Access to 2,5‐Diamidopyrroles and 2,5‐Diamidofurans by Au(I)‐Catalyzed Double Hydroamination or Hydration of 1,3‐Diynes.
Authors: Kramer Soeren , Madsen Julie L. H. , Rottlaender Mario , Skrydstrup Troels
Published: October 2010

A variety of 2,5‐diamido‐pyrroles and furans is prepared starting from the bisacetylenes and anilines or water, respectively [cf.
ChemInform Abstract: Application of meso‐Hydrobenzoin‐Derived Chiral Auxiliaries for the Stereoselective Synthesis of Highly Substituted Pyrrolidines by 1,3‐Dipolar Cycloaddition of Azomethine Ylides.
Authors: Bica Katharina , Gaertner Peter
Published: October 2010

Acrylic ester derivatives (I) possessing meso‐hydrobenzoin derived chiral auxiliaries undergo cycloaddition with the azomethine (II) to give the highly substituted pyrrolidines (III) with up to 87% e.e.
ChemInform Abstract: Catalytic C—CN Activation and Asymmetric Cyanoamidation of Alkenes: Total Syntheses of (+)‐Horsfiline, (‐)‐Coerulescine, and (‐)‐Esermethole.
Authors: Reddy Venkata Jaganmohan , Douglas Christopher J.
Published: October 2010

A diversity of oxindoles bearing quaternary all‐carbon stereocenters, e.g. (II) or (V), is prepared by cyanoamidation reaction of corresponding cyanoformamides.
ChemInform Abstract: New Three‐Component Glyoxylation—Decarbonylative Stille Coupling Sequence to Acyl Heterocycles under Mild Conditions.
Authors: Tasch Boris O. A. , Merkul Eugen , Frank Walter , Mueller Thomas J. J.
Published: October 2010

A convenient one‐pot procedure is developed for the title process of indoles or pyrroles.
ChemInform Abstract: First Example of a Synthesis of the Tetracyclic 2,4‐Di(tert‐butyl)‐6,7‐dihydrofuro[2′,3′:3,4]cyclohepta[1,2‐b]indole System.
Authors: Butin A. V. , Kostyukova N. O. , Tsiunchik F. A. , Lysenko S. A. , Trushkov I. V.
Published: October 2010

Title compounds (II) are obtained by the action of POCl3 and a drop of water on bisfurylmethanes (I).
ChemInform Abstract: Exploration of the Interrupted Fischer Indolization Reaction.
Authors: Schammel Alex W. , Boal Ben W. , Zu Liansuo , Mesganaw Tehetena , Garg Neil K.
Published: October 2010

Condensation of various aromatic hydrazines with masked aldehydes, i.e.
ChemInform Abstract: Novel Antiinflammatory Agents Based on Pyrazole Based Dimeric Compounds; Design, Synthesis, Docking and in vivo Activity.
Authors: Tewari Ashish Kumar , Srivastava Priyanka , Singh Ved Prakash , Singh Amit , Goel Raj Kumar , Mohan Chethampadi Gopi
Published: October 2010

The biological in vivo evaluation of the synthesized mutual ester prodrugs such as (V) and (VI) shows the presence of antiinflammatory activity.
ChemInform Abstract: Synthesis of 3,5‐Diaryl‐4‐(1H‐imidazol‐2‐yl)‐1H‐pyrazoles from 2‐Phenacyl‐1H‐imidazole.
Authors: Dzvinchuk I. B. , Nesterenko A. M. , Lozinskii M. O.
Published: October 2010

The previously unknown title compounds (IV) are synthesized through thermal intramolecular cyclocondensation of hydrazones (III).
ChemInform Abstract: Synthesis of Benzimidazoles and Benzoxazoles Using Palladium Bis(2,2,6,6‐Tetramethyl‐3,5‐heptanedionate) as a Novel Catalyst.
Authors: Bhor Malhari D. , Bhanage Bhalchandra M.
Published: October 2010

The title catalyst (PTMHD) is efficiently used for the preparation of benzimidazoles, e.g. (III) and (VI), and benzoxazoles such as (VIII).
ChemInform Abstract: Synthesis, Characterization and in vivo Anthelmintic Activity of Some Novel N‐Mannich Bases of Benzimidazoles.
Authors: Murti Yogesh , Arora Rashmi , Pathak Devender
Published: October 2010

Most of the title compounds (I)‐(III) exhibit significant anthelmintic activities against Eudrilus species.
ChemInform Abstract: Efficient Suzuki and Stille Reactions for Regioselective Strategies of Incorporation of the 1,3‐Oxazole Heterocycle: Mild Desulfonylation for the Synthesis of C‐4 and C‐5 Monosubstituted Oxazoles.
Authors: Williams David R. , Fu Liangfeng
Published: October 2010

Various oxazole substrates can be used for successful title reactions.
ChemInform Abstract: Direct Access to Variously Substituted 2‐Imino‐4‐thiazolines.
Authors: Attanasi Orazio A. , Favi Gianfranco , Filippone Paolino , Perrulli Francesca R. , Santeusanio Stefania
Published: October 2010

Thiocyanic acid, generated in situ from KSCN and acetic acid, reacts with 1,2‐diaza‐1,3‐butadienes to afford intermediate α‐thiocyanato hydrazones.
ChemInform Abstract: Preparation and N‐Alkylation of 4‐Aryl‐1,2,4‐triazoles.
Authors: Holm Stefanie C. , Siegle Alexander F. , Loos Christian , Rominger Frank , Straub Bernd F.
Published: October 2010

A simple solvent‐free protocol allows the preparation of biologically interesting title compounds from dihydrochloride (I) and anilines via direct transamination.
ChemInform Abstract: γ‐Lactonizations of 2H‐Chromenes via Cyclopropanation.
Authors: Stokes Sean , Spears Ben , Laseter Cameron , Barker Bobby , Mead Keith T.
Published: October 2010

The two‐step sequence involves cyclopropanation of 2H‐chromenes with diazo esters and Lewis acid promoted ring expansion of the resulting cyclopropanes.
ChemInform Abstract: Enantioselective Synthesis of 3,4‐Chromanediones via Asymmetric Rearrangement of 3‐Allyloxyflavones.
Authors: Marie Jean‐Charles , Xiong Yuan , Min Geanna K. , Yeager Adam R. , Taniguchi Tohru , Berova Nina , Schaus Scott E. , Porco John A. Jr.
Published: October 2010

The 3,4‐chromanediones are trapped with phenylenediamine and ethylenediamine to afford chiral pyrazine derivatives.
ChemInform Abstract: Amberlite IRA‐400 (OH‐) as a Catalyst in the Preparation of 4H‐Benzo[b]pyrans in Aqueous Media.
Authors: Khodaei Mohammad Mehdi , Bahrami Kiumars , Farrokhi Azita
Published: October 2010

Amberlite IRA‐400 (OH‐) is an effective and reusable catalyst for the synthesis of the title benzopyrans (IV) (12 examples) via one‐pot, three component condensation of dimedone, aldehydes and malononitrile.
ChemInform Abstract: Highly Enantioselective Formal aza‐Diels—Alder Reactions with Acylhydrazones and Danishefsky′s Diene Promoted by a Silicon Lewis Acid.
Authors: Lee Sharon K. , Tambar Uttam K. , Perl Nicholas R. , Leighton James L.
Published: October 2010

Lewis acidic oxazasilolane (I) is successfully applied as promoter in the formal aza‐Diels—Alder reaction of acylhydrazones (II) towards Danishefsky diene (III).
ChemInform Abstract: A Facile Synthesis and Discovery of Highly Functionalized Tetrahydropyridines and Pyridines as Antimycobacterial Agents.
Authors: Raju Suresh Kumar , Stephen Michael Rajesh , Subbu Perumal , Debjani Banerjee , Perumal Yogeeswari , Dharmarajan Sriram
Published: October 2010

A variety of novel highly functionalized tetrahydropyridine derivatives is synthesized via multicomponent reactions of arylsulfonylbutanoates (I) with aromatic aldehydes and ammonium acetate and transformed into corresponding aromatics upon dehydrogenation with DDQ.
ChemInform Abstract: A Route to Alkenyl‐Substituted 4‐Hydroxypyridine and Pyrimidine Derivatives via Three‐Component Access to β‐Alkoxy‐β‐ketoenamides.
Authors: Bera Mrinal K. , Reissig Hans‐Ulrich
Published: October 2010

The title reaction affords β‐keto enamides (IV).
ChemInform Abstract: Polycyclic N‐Heterocyclic Compounds. Part 64. Synthesis of 5‐Amino‐1,2,6,7‐tetrahydrobenzo[f]furo[2,3‐c]isoquinolines and Related Compounds. Evaluation of Their Bronchodilator Activity and Effects on Lipoprotein Lipase mRNA Expression.
Authors: Okuda Kensuke , Deguchi Hiroshi , Kashino Setsuo , Hirota Takashi , Sasaki Kenji
Published: October 2010

A method for the synthesis of benzo‐fused 5‐aminocycloalkeno[1,2‐d]furo[2,3‐b]pyridines (IV) via Truce—Smiles rearrangement is developed.
ChemInform Abstract: New Pyrrolo[1,2‐b]pyridazine Derivatives.
Authors: Dumitrascu Florea , Draghici Constantin , Caproiu Miron T. , Dumitrescu Dan G. , Popa Marcel Mirel
Published: October 2010

The title compounds (IV) (7 examples) are regioselectively obtained in a three‐component one‐pot reaction between pyridazine (I), phenacyl bromides (II), and 1‐butyn‐3‐one (III) in the presence of 1,2‐epoxybutane as reaction medium and acid scavenger.
ChemInform Abstract: A One‐Pot Sulfide to Sulfone Oxidation with m‐Chloroperoxybenzoic Acid and Sodium Permanganate.
Authors: Dishington Allan , Fillery Shaun , Finlay M. Raymond V.
Published: October 2010

The reagent combination allows a selective transformation in the presence of other oxidizable functions.
ChemInform Abstract: Synthesis of Fused Pyrimidone Derivatives of 4‐Pyrones from the Acetates of Baylis—Hillman Adducts (V).
Authors: Shahrisa A. , Ghasemi Z.
Published: October 2010

Title compounds (VII) and (IX) are synthesized starting by Baylis—Hillman reaction of formylpyrones (I) under convenient conditions.
ChemInform Abstract: Microwave‐Assisted One‐Pot Synthesis of Octahydroquinazolinone Derivatives Using Ammonium Metavanadate under Solvent‐Free Condition.
Authors: Niralwad Kirti S. , Shingate Bapurao B. , Shingare Murlidhar S.
Published: October 2010

The readily available inexpensive catalyst renders possible a rapid and efficient access to the biologically interesting skeleton.
ChemInform Abstract: Highly Efficient Synthesis of 2,3‐Dihydroquinazolin‐4(1H)‐ones Catalyzed by Heteropoly Acids in Water.
Authors: Zong YingXiao , Zhao Yan , Luo WenCai , Yu Xing Hai , Wang Jun Ke , Pan Yi
Published: October 2010

H3PW12O40 is described as highly for efficient the condensation of anthranilamides with aromatic aldehydes.
ChemInform Abstract: A Convenient Synthesis of Quinazoline Derivatives via Cascade Imino‐Diels—Alder and Oxidation Reaction.
Authors: Chen Xue Ming , Wei Hui , Yin Lu , Li Xing Shu
Published: October 2010

The reaction occurs between 2 α‐iminoesters, which can be generated in situ from anilines and ester (II) or introduced directly.
ChemInform Abstract: Heteroannulated Quinazoline and Quinazolinone Derivatives from (Z)‐2‐[1‐Benzamido‐2‐(3,4,5‐trimethoxyphenyl)] vinyl‐3,1‐benzoxazin‐4(3H)‐one.
Authors: Mahmoud Mahmoud R. , Derbala Hamed A. Y.
Published: October 2010

Benzoxazinone (I) reacts with different nitrogen nucleophiles leading to various quinazoline and quinazolinone derivatives.
ChemInform Abstract: Concise Two‐Step Solution Phase Syntheses of Four Novel Dihydroquinazoline Scaffolds.
Authors: Dietrich Justin , Kaiser Christine , Meurice Nathalie , Hulme Christopher
Published: October 2010

Ugi four‐component reaction of mono N‐Boc protected o‐aminobenzylamines such as (I) and following acid catalyzed dehydrative cyclization offers a simple route to different types of pharmaceutically important title scaffolds.
ChemInform Abstract: Diversity‐Oriented Synthesis of Dibenzoazocines and Dibenzoazepines via a Microwave‐Assisted Intramolecular A3‐Coupling Reaction.
Authors: Bariwal Jitender B. , Ermolat'ev Denis S. , Glasnov Toma N. , Van Hecke Kristof , Mehta Vaibhav P. , Van Meervelt Luc , Kappe C. Oliver , Van der Eycken Erik V.
Published: October 2010

The method allows the introduction of five different points of diversity in the products.
ChemInform Abstract: Ethynyl MIDA Boronate: A Readily Accessible and Highly Versatile Building Block for Small Molecule Synthesis.
Authors: Struble Justin R. , Lee Suk Joong , Burke Martin D.
Published: October 2010

Ethynyl N‐methyliminodiacetic acid boronate (I) is successfully applied in the regioselective iterative synthesis of arylethyne (III) and tolan derivatives, e.g. (IV).
ChemInform Abstract: Diversity‐Oriented Synthesis of Disubstituted Alkenes Using Masked Silanols.
Authors: Sore Hannah F. , Blackwell David T. , MacDonald Simon J. F. , Spring David R.
Published: October 2010

The preparation methods for the (E)‐ and α‐disubstituted alkenes are developed using the reaction of pentafluorodimethylsilane (I) and alkynes (II) with the proper choice of a catalyst, yielding the corresponding pentafluorodimethylvinylsilanes, and the following cross‐coupling reaction with the aryl iodides [cf.
ChemInform Abstract: Synthesis of β‐Aminovinylphosphonates by Organocatalytic Nucleophilic Displacement of Acetate with Amines.
Authors: Garzon Cecile , Attolini Mireille , Mafei Michel
Published: October 2010

A broad spectrum of structurally diverse amines reacts with vinyl phosphonate (I) to give important building blocks.
ChemInform Abstract: Catalytic Enantioselective Total Syntheses of Bakkenolides I, J, and S: Application of a Carbene‐Catalyzed Desymmetrization.
Authors: Phillips Eric M. , Roberts John M. , Scheidt Karl A.
Published: October 2010

The key step of the synthesis of bakkenolides S (III), I (IVa) and J (IVb) is a tandem homoenolate protonation, intramolecular aldol addition and acylation of (I), catalyzed by an N‐heterocyclic carbene (MTC).
ChemInform Abstract: α‐Glucosidase Inhibition Properties of Cucurbitane‐Type Triterpene Glycosides from the Fruits of Momordica charantia
Authors: Kim Young Ho , et al. et al.
Published: October 2010

isolation, structure elucidation and biological activities of fourteen cucurbitane‐type triterpene glycosides, including three new compounds named charantosides A—C (I)—(III)
ChemInform Abstract: Five New Triterpene Bisglycosides with Acyclic Side Chains from the Rhizomes of Cimicifuga foetida L.
Authors: Lu Lu , Chen Jian‐Chao , Song He‐Jiao , Li Yan , Nian Yin , Qiu Ming‐Hua
Published: October 2010

isolation, structure and cytotoxicity of one lanostane bisglycoside, foetidinoside A (I), one seco‐cycloartane type bisglycoside, foetidinoside B (II), and three new cycloartane‐type bisglycosides, foetidinoside C (III), D and E
ChemInform Abstract: Transformation of 5,8‐Dimethyl‐1‐tetralone: Synthesis of Ar‐occidol.
Authors: Banerjee Ajoy K. , Vera Willam J. , Cabrera Elvia V. , Sanchez Jennifer L.
Published: October 2010

A new approach for the synthesis of ar‐occidol (VI), the aromatic analogue of naturally occurring sesquiterpene occidol is developed.
ChemInform Abstract: Trigochinins D—I: Six New Daphnane‐Type Diterpenoids from Trigonostemon chinensis.
Authors: Chen Hua‐Dong , Yang Sheng‐Ping , He Xiu‐Feng , Liu Hong‐Bing , Ding Jian , Yue Jian‐Min
Published: October 2010

Trigochinins E (Ib) and F (Ic) exhibit a strong inhibiting activity against the HL‐60 tumor cell line.
ChemInform Abstract: First Total Synthesis of 11‐Tellura Steroids
Authors: Ibrahim‐Ouali Malika
Published: October 2010

which may have biological significance
ChemInform Abstract: Cytotoxic Cardenolides from the Leaves of Calotropis gigantea.
Authors: Seeka Chonticha , Sutthivaiyakit Somyote
Published: October 2010

15‐β‐Hydroxycardenolides (Ia), (Ib) and 16‐α‐hydroxycalactinic acid methyl ester (Ic) are isolated from the leaves of Calotropis gigantea along with eleven known compounds.
ChemInform Abstract: Glycine Amides as PPARα Agonists.
Authors: Urbahns Klaus , Woltering Michael , Nikolic Susanne , Pernerstorfer Josef , Bischoff Hilmar , Dittrich‐Wengenroth Elke , Lustig Klemens
Published: October 2010

Among a variety of glycine amides, prepared as shown in the scheme, the derivative (VI) is a potent and specific glycine amide with oral bioavailability in rodents.
ChemInform Abstract: A General Approach to the Synthesis of β2‐Amino Acid Derivatives via Highly Efficient Catalytic Asymmetric Hydrogenation of α‐Aminomethylacrylates.
Authors: Guo Yujuan , Shao Guang , Li Lanning , Wu Wenhao , Li Ruihong , Li Jingjing , Song Jian , Qiu Liqin , Prashad Mahavir , Kwong Fuk Yee
Published: October 2010

The asymmetric hydrogenations of α‐(aminomethyl)acrylates using rhodium(Et‐DuPHOS) catalysts give the corresponding β2‐amino acids with up to <99.5% e.e.
ChemInform Abstract: Phenylethanoid and Iridoid Glycosides in the New Zealand Snow Hebes (Veronica, Plantaginaceae)
Authors: Taskova Rilka M. , Kokubun Tetsuo , Ryan Ken G. , Garnock‐Jones Phil John , Jensen Soren Rosendal
Published: October 2010

isolation and structure determination of 33 compounds including 14 previously unknown esters of phenylethanoid glycosides named chionosides, e.g. (I), and isochionosides, e.g. (II)
ChemInform Abstract: Glycosylation from Non‐Reducing End Using a Combination of Thioglycoside and Glycosyl Sulfoxide as the Glycosyl Donor and the Acceptor.
Authors: Kajimoto Tetsuya , Arimitsu Kenji , Ozeki Minoru , Node Manabu
Published: October 2010

A novel strategy for the synthesis of oligosaccharides is presented.
ChemInform Abstract: Synthesis of (‐)‐Paroxetine via Enantioselective Phase‐Transfer Catalytic Monoalkylation of Malonamide Ester.
Authors: Kim Mi‐hyun , Park Yohan , Jeong Byeong‐Seon , Park Hyeung‐geun , Jew Sang‐sup
Published: October 2010

The synthesis is achieved with the enantioselective phase‐transfer catalytic alkylation to yield (III) and the diastereoselective Michael addition affording (VI) with 96% d.e.
ChemInform Abstract: Epoxide Opening‐Induced Tandem 8‐Azabicyclo[3.2.1]octane to 6‐Azabicyclo[3.2.1]octane Rearrangement—Iminium Allylation: Synthesis of (.+‐.)‐Peduncularine.
Authors: Hodgson David M. , Shelton Ruth E. , Moss Thomas A. , Dekhane Mouloud
Published: October 2010

The rearrangement of (I) is promoted by TmsOTf and affords (III) in high yield.
ChemInform Abstract: Cyclic Spermidine Alkaloids and Flavone Glycosides from Meehania fargesii.
Authors: Murata Toshihiro , Miyase Toshio , Yoshizaki Fumihiko
Published: October 2010

Two new spermidine alkaloids, meefarnines A and B and four new flavone glycosides, fargenins A‐D (II) are isolated from the whole plant of Meehania fargesii along with ten known compounds.
ChemInform Abstract: Novoamauromine (I) and ent‐Cycloechinulin (II): Two New Diketopiperazine Derivatives from Aspergillus novofumigatus
Authors: Ishikawa Kazuki , Hosoe Tomoo , Itabashi Takeshi , Wakana Daigo , Takizawa Kayoko , Yaguchi Takashi , Kawai Ken‐ichi
Published: October 2010

isolation, structure, antifungal and cytotoxic activities
ChemInform Abstract: One‐Pot Synthesis of the Naturally Occurring Dimeric Carbazole Alkaloid Murranimbine and Its Analogue.
Authors: Chakraborty Mumu , Mukhopadhyay Sibabrata
Published: October 2010

BF3·OEt2‐catalyzed dimerization of girinimbine (Ia) provides title compound murranimbine (IIa) in one step.
ChemInform Abstract: New Phenylpropanoid Glycosides from Juniperus communis var. depressa.
Authors: Iida Naoki , Inatomi Yuka , Murata Hiroko , Murata Jin , Lang Frank A. , Tanaka Toshiyuki , Nakanishi Tsutomu , Inada Akira
Published: October 2010

Two new phenylpropanoid glycosides (I) and (II) are isolated along with several known substances from leaves and stems of the North American title plant.
ChemInform Abstract: Enantioselective Synthesis of (+)‐Patulolide C (VIIb) via Proline‐Catalyzed Sequential α‐Aminooxylation and Horner—Wadsworth—Emmons Olefination.
Authors: Sabitha Gowravaram , Chandrashekhar G. , Yadagiri K. , Yadav J. S.
Published: October 2010

The sequence starts with Jacobsen′s kinetic resolution.
ChemInform Abstract: Chemoenzymatic Synthesis and Cannabinoid Activity of a New Diazabicyclic Amide of Phenylacetylricinoleic Acid.
Authors: Lopez‐Ortiz Manuel , Herrera‐Solis Andrea , Luviano‐Jardon Axel , Reyes‐Prieto Nidia , Castillo Ivan , Monsalvo Ivan , Demare Patricia , Mendez‐Diaz Monica , Regla Ignacio , Prospero‐Garcia Oscar
Published: October 2010

A chemoenzymatic synthesis of a new diazabicyclic amide (IV) of phenylacetylricinoleic acid is presented.
ChemInform Abstract: Papuabalanols A and B, New Tannins from Balanophora papuana.
Authors: Hosoya Takahiro , Nakata Asami , Zaima Kazumasa , Latip Jalifah , Din Laily Bin , Muslim Noramly , Morita Hiroshi
Published: October 2010

Papuabalanol A (Ib) shows moderate vasodilator effect on rat aorta while papuabalanol B (Ia) shows potent inhibition of mushroom tyrosinase and anti‐melanogenesis in B16 mouse melanoma cells.
ChemInform Abstract: Total Synthesis and Stereochemical Reassignment of Bisebromoamide.
Authors: Gao Xuguang , Liu Yuqing , Kwong Shuqin , Xu Zhengshuang , Ye Tao
Published: October 2010

The total synthesis of (I) reveals a reassignment of the stereogenic center at the thiazoline ring.
ChemInform Abstract: Discovery of 4‐{1‐[({1‐ [4‐(Trifluoromethyl)benzyl]‐1H‐indol‐7‐yl}carbonyl)amino] cyclopropyl}benzoic Acid (MF‐766), a Highly Potent and Selective EP4 Antagonist for Treating Inflammatory Pain.
Authors: Han Yongxin , et al. et al.
Published: October 2010

The synthesis of the second generation EP4 antagonist MF‐766 (I) is accomplished in four steps from an easily accessible methyl indolecarboxylate.
ChemInform Abstract: Element Specific Versus Integral Structural and Magnetic Properties of Co:ZnO and Gd:GaN Probed with Hard X‐Ray Absorption Spectroscopy
Authors: Ney Andreas
Published: October 2010

Review: 157 refs.
ChemInform Abstract: Single‐Electron‐Spin Measurements in Si‐Based Semiconductor Nanostructures
Authors: Jiang H. W. , Yablonovitch E. , Xiao M. , Sakr M. , Scott G. , Croke E. T.
Published: October 2010

Review: 33 refs.
ChemInform Abstract: Cathode Processes and Materials for Solid Oxide Fuel Cells with Proton Conductors as Electrolytes
Authors: Peng Ranran , Wu Tianzhi , Liu Wei , Liu Xingqin , Meng Guangyao
Published: October 2010

Review: 63 refs.
ChemInform Abstract: Graphene and Graphene Oxide: Synthesis, Properties, and Applications
Authors: Zhu Yanwu , Murali Shanthi , Cai Weiwei , Li Xuesong , Suk Ji Won , Potts Jeffrey R. , Ruoff Rodney S.
Published: October 2010

Review: 260 refs.
ChemInform Abstract: Controlled Synthesis of One‐Dimensional Inorganic Nanostructures Using Pre‐Existing One‐Dimensional Nanostructures as Templates
Authors: Liang Hai‐Wei , Liu Shuo , Yu Shu‐Hong
Published: October 2010

Review: 162 refs.
ChemInform Abstract: Phosphorescent Chemosensors Based on Heavy‐Metal Complexes
Authors: Zhao Qiang , Li Fuyou , Huang Chunhui
Published: October 2010

Review: 217 refs.
ChemInform Abstract: Metal‐Catalyzed Direct Alkylations of (Hetero)arenes via C—H Bond Cleavages with Unactivated Alkyl Halides
Authors: Ackermann Lutz
Published: October 2010

Review: 115 refs.
ChemInform Abstract: Stimulation on the Addition Reactivity of Fluorinated Vinyl Monomers — Facile Carbon—Carbon Bond Formation by the Aid of Fluorine Substituents
Authors: Narita Tadashi
Published: October 2010

Review: 23 refs.
ChemInform Abstract: Organic Hypervalent Iodine Chemistry Spanning Three Centuries — A Historical Overview
Authors: Varvoglis Anastasios
Published: October 2010

Review: 24 refs.
ChemInform Abstract: “Aromatic Ring Umpolung”, a Rapid Access to the Main Core of Several Natural Products.
Authors: Guerard Kimiaka C. , Sabot Cyrille , Beaulieu Marc‐Andre , Giroux Marc‐Andre , Canesi Sylvain
Published: October 2010

Review: 105 refs.
ChemInform Abstract: Rolf Huisgen′s Profound Adventures in Chemistry
Authors: Houk Kendall N.
Published: October 2010

Review: 20 refs.
ChemInform Abstract: Recent Progress in the Chemistry of Supercarboranes
Authors: Zhang Jian , Xie Zuowei
Published: October 2010

Review: about 50 refs.
ChemInform Abstract: Difluoromethylenephosphonates: Synthesis and Transformations
Authors: Chunikhin K. S. , Kadyrov A. A. , Pasternak P. V. , Chkanikov N. D.
Published: October 2010

Review: 153 refs.
ChemInform Abstract: Recent Advances in Endomorphin Engineering
Authors: Keresztes Attila , Borics Attila , Toth Geza
Published: October 2010

Review: 171 refs.
ChemInform Abstract: Orexin Receptor Antagonists: A New Concept in CNS Disorders?
Authors: Gatfield John , Brisbare‐Roch Catherine , Jenck Francois , Boss Christoph
Published: October 2010

Review: 145 refs.
ChemInform Abstract: Asymmetric Organocatalysis in Total Synthesis — A Trial by Fire
Authors: Marques‐Lopez Eugenia , Herrera Raquel P. , Christmann Mathias
Published: October 2010

Review: about 200 refs.
ChemInform Abstract: Ciguatoxin: Developing the Methodoloy for Total Synthesis
Authors: Isobe Minoru , Hamajima Akinari
Published: October 2010

Review: 111 refs.
ChemInform Abstract: Synthesis, Reactivity and Biological Activity of Quinoxalinone Derivatives
Authors: Ramli Y. , Benzeid H. , Bouhfid R. , Rodi Y. Kandri , Ferfra S. , Essassi E. M.
Published: October 2010

Review: 100 refs.
ChemInform Abstract: Chemistry of Nitroquinolones and Synthetic Application to Unnatural 1‐Methyl‐2‐quinolone Derivatives
Authors: Nishiwaki Nagatoshi
Published: October 2010

Review: 52 refs.
ChemInform Abstract: Azaphthalocyanines Containing Pyrazine Rings with Focus on the Alkylheteroatom, Aryl and Heteroaryl Substitution and Properties Important in Photodynamic Therapy
Authors: Zimcik Petr , Novakova Veronika , Miletin Miroslav , Kopecky Kamil
Published: October 2010

Review: 69 refs.
ChemInform Abstract: Sonochemistry of Homogeneous Ionic Reactions
Authors: Tuulmets A. , Cravotto G. , Salmar S. , Jarv J.
Published: October 2010

Review: 58 refs.
ChemInform Abstract: Dynamics in Organic Inclusion Crystals of Steroids and Primary Ammonium Salts
Authors: Miyata Mikiji , Tohnai Norimitsu , Hisaki Ichiro
Published: October 2010

Review: 42 refs.
ChemInform Abstract: Carbohydrate Functionalized Carbon Nanotubes and Their Applications
Authors: Gorityala Bala Kishan , Ma Jimei , Wang Xin , Chen Peng , Liu Xue‐Wei
Published: October 2010

Review: 60 refs.
ChemInform Abstract: Proton‐Conducting Membranes Based on Benzimidazole Polymers for High‐Temperature PEM Fuel Cells. A Chemical Quest
Authors: Asensio Juan Antonio , Sanchez Eduardo M. , Gomez‐Romero Pedro
Published: October 2010

Review: 317 refs.
ChemInform Abstract: Functional Hybrid Materials with Polymer Nanoparticles as Templates
Authors: Ethirajan Anitha , Landfester Katharina
Published: October 2010

Review: 104 refs.
ChemInform Abstract: Amyloidogenic Protein—Membrane Interactions: Mechanistic Insight from Model Systems
Authors: Butterfield Sara M. , Lashuel Hilal A.
Published: October 2010

Review: ca. 200 refs.
ChemInform Abstract: NMR Spectroscopy in Ionic Liquids
Authors: Giernoth Ralf
Published: October 2010

Review: 81 refs.
ChemInform Abstract: NMR Studies for Mapping Structure and Dynamics of Nucleosides in Water
Authors: Ancian Bernard
Published: October 2010

Review: 710 refs.
ChemInform Abstract: Green Analytical Chemistry —Theory and Practice
Authors: Tobiszewski Marek , Mechlinska Agata , Namiesnik Jacek
Published: October 2010

Review: 49 refs.
Neutrophil phagocytosis by tumor cells—A cytological study
Authors: Singhal Niti , Handa Uma , Bansal Cherry , Mohan Harsh
Published: October 2010

Cell cannibalism is defined as the ability of a cell to phagocytose another cell. Malignant tumor cells may develop phagocytic property and demonstrate phagocytosis of own cells or cells of other series like neutrophils and lymphocytes. We report 11 cases in which the tumor cells showed evidence of neutrophil phagocytosis/emperipolesis on FNAC smears.

Cases of malignancies diagnosed on FNA over a period of 1 year were retrieved, and smears were examined for neutrophil phagocytosis by tumor cells. These cases were classified according to type and differentiation of malignancy. The cytomorphological features and background inflammation were also studied at both primary and metastatic site.

Of 362 malignant cases diagnosed on FNA smears, in 11 cases (3.09%), tumor cells showed neutrophil phagocytosis. The background showed increase in polymorphs in all cases. All the cases were associated with metastasis at presentation and were high‐grade tumors cytologically. There were three cases of anaplastic carcinoma, two cases of adenocarcinoma, two cases of carcinoma breast, two cases of anaplastic non‐Hodgkins lymphoma, one case each of squamous cell carcinoma and small cell carcinoma from larynx and lung, respectively.

Phagocytic activity by tumor cells is uncommon and usually seen in high‐grade/poorly differentiated malignancies. It is frequently associated with metastatic disease. On cytology smears, true phagocytosis of neutrophils by tumor cells has to be distinguished from superimposed inflammatory cells from the background. The tumor cells also need to be distinguished from histiocytes displaying phagocytosis. Diagn. Cytopathol. 2011. © 2010 Wiley‐Liss, Inc.
Fascin stain as a potential marker of invasiveness in carcinomas of the urinary bladder: A retrospective study with biopsy and cytology correlation
Authors: McKnight Ryan , Cohen Cynthia , Siddiqui Momin T.
Published: October 2010

The evaluation of invasion in urothelial carcinomas of the urinary bladder cannot be determined on cytology and can be particularly challenging in biopsy cases with limited sampling. Recent studies of bladder resection specimens suggest that fascin overexpression may be a marker of aggressive urothelial carcinomas and can help facilitate the assessment of invasion. In this study, we evaluated urine cytology and corresponding biopsy specimens with proven invasive urothelial carcinoma for fascin expression by immunohistochemistry. Thirty‐five patients diagnosed with positive urine cytology and biopsy‐proven invasive urothelial carcinoma between January 2003 and February 2009 were identified. We found increased fascin expression in 100% (35/35) of SurePathTM&!trade; urine cytology preparations as well as 100% (35/35) of corresponding biopsy cases with invasive urothelial carcinoma. On urine cytology, cytoplasmic fascin staining was moderate to intense in malignant tumor cell clusters and single cells and not observed in benign urothelial cells. Staining in biopsy cases was generally intense and cytoplasmic and present in both the invasive (100%) and noninvasive (31%) components of the lesion. These findings uphold the association of increased fascin expression in invasive urothelial carcinomas of the urinary bladder. We furthermore demonstrate that fascin staining can be performed successfully on SurePathTM&!trade; urine cytology preparations in which increased fascin expression correlates with invasion on biopsy. While not a definitive marker of invasion, as it is observed in in situ carcinoma, we conclude that the utilization of fascin immunohistochemistry on urine cytology might serve as a useful adjunct in predicting invasiveness in subsequent biopsies. Diagn. Cytopathol. 2010. © 2010 Wiley‐Liss, Inc.
Core needle biopsy versus fine needle aspiration biopsy in breast—A historical perspective and opportunities in the modern era
Authors: Nassar Aziza
Published: October 2010

Breast fine‐needle aspiration biopsy (FNAB) by palpation is on the decline, due to its limitations in diagnostic accuracy, decreased sensitivity, and its replacement with core needle biopsy (CNB). Despite its decreasing utility, superficial fine‐needle aspiration (FNA) in breast is still the main modality for evaluating metastatic lesions, recurrence, and axillary lymph node metastasis. New modalities including proteomic pattern expression and methylation profiling of breast lesions are other promising techniques that can be used as ancillary tests for refining the diagnosis of breast lesions using FNAB. Image‐guided breast FNA proves to be a successful alternative with high sensitivity and specificity. In this review, the advantages, disadvantages, and inherent limitations of breast FNA and CNB, and new advanced techniques are discussed. Diagn. Cytopathol. 2011. © 2010 Wiley‐Liss, Inc.
Extramedullary hematopoiesis presented as solitary renal mass: A case report with review of literature
Authors: Ahuja Shweta , Grover Geetanjali , Jha Ajay Kumar , Sodhi Kushaljit , Bansal Deepak , Dey Pranab
Published: October 2010

In this article, we described a case of extramedullary hematopoiesis (EMH) in a 12‐year‐old boy with the clinical and hematological features of hemolytic anemia of unknown cause. The patient presented with a solitary well circumscribed mass in right kidney. Ultrasound guided fine‐needle aspiration cytology showed myelocytes, metamyelocytes, megakaryocytes, and immature erythroid cells. A cytological diagnosis of EMH was made. Diagn. Cytopathol. 2011. © 2010 Wiley‐Liss, Inc.
Unusual clinical presentation of cutaneous malignant melanoma metastatic to the parotid gland; Initially discovered by fine needle aspiration: Case report and review of literature
Authors: Elshenawy Yasmin , Youngberg George , Al‐Abbadi Mousa A.
Published: October 2010

We report a case of malignant melanoma (MM) metastatic to the parotid gland, initially discovered on fine needle aspiration (FNA). The patient presented with a mass in the parotid gland area with previous history only significant for prostatic carcinoma. The initial FNA impression was melanoma. The smears were hypercellular with bloody necrotic background. The cells were epithelioid with mild nuclear atypia. Discrete cytoplasmic pigmentation was seen. No lymphoglandular bodies were noticed. Fragments of benign salivary gland were also identified. The cytological diagnosis of MM triggered onsite thorough physical examination for potential primary, where a scalp pigmented lesion was discovered hidden by overlying covering hair. Our differential diagnosis included melanoma, metastatic carcinoma, and lymphoma. Further work up for melanoma with S100, HMB45, and Mart 1 confirmed our top differential diagnosis. We emphasize thorough physical examination in such circumstances, and the importance of onsite evaluation guiding clinicians looking for primary. Diagn. Cytopathol. 2011. © 2010 Wiley‐Liss, Inc.
Minimizing the diagnosis of “follicular lesion of undetermined significance” and identifying predictive features for neoplasia
Authors: Jing Xin , Roh Michael H. , Knoepp Stewart M. , Zhao Lili , Michael Claire W.
Published: October 2010

We used proposed standard morphologic criteria as a guideline to conduct a 10‐year retrospective review of thyroid fine‐needle aspiration specimens that were originally interpreted as “follicular lesion of undetermined significance” and followed by surgical intervention. We sought to investigate whether the indeterminate diagnosis could be minimized by assessing various cytomorphologic features and identifying the features predictive of neoplasia. Using the standard morphologic criteria, we semi‐quantitatively assessed a total of 24 cytomorphologic features in 123 aspirates and recorded an overall interpretation on completion of the review. Cyto‐histologic correlation was evaluated and logistic regression model was performed to identify cytomorphologic features predictive of neoplasia. Although 32 of 123 aspirates remained in the indeterminate category, the retrospective review reclassified 64 aspirates as non‐neoplasia and 27 aspirates as neoplasia. Histologic confirmation was achieved in 47 (73.4%) non‐neoplastic and 15 (55.6%) neoplastic aspirates with a diagnostic accuracy of 68.1%. Furthermore, our analysis demonstrated that neoplasia is positively associated with the presence of syncytial tissue fragments, isolated microfollicles, follicles with scalloped borders, scant cytoplasm, irregular nuclear membranes, nuclear overlapping, coarse chromatin, and increased cellularity. On the contrary, the presence of honeycombing tissue fragments, background colloid, and histiocytes inversely correlated with neoplasia.

Overall, using proposed standard morphological criteria can minimize the diagnosis of “follicular lesion of undetermined significance,” and allow for more accurate cyto‐histologic correlation, and thereby playing a substantial role in reducing unnecessary surgical intervention. Diagn. Cytopathol. 2010. © 2010 Wiley‐Liss, Inc.
A comparative study of 200 head and neck FNAs performed by a cytopathologist with versus without ultrasound guidance: Evidence for improved diagnostic value with ultrasound guidance
Authors: Wu Maoxin
Published: October 2010

Our previous study showed that the sensitivity of head and neck fine‐needle aspiration (FNA) procedures was significantly better in the cytopathologist‐performed group than in the noncytopathologist‐performed group (96 versus 67%). Recently, cytopathologists have learned to use ultrasound machines to assist them in performing FNA procedures. This study was designed to assess whether cytopathologist‐performed FNAs with ultrasound guidance can improve diagnostic value in comparison to those done without ultrasound guidance. Two hundred consecutive head and neck FNA cases performed by the same cytopathologist with and without ultrasound guidance were reviewed. Cases consisted of 100 ultrasound‐guided FNAs (USGFNAs) performed between July 2008 and March 2009 and 100 palpation‐guided FNAs (PGFNAs) performed before July 2008. These cases were correlated with follow‐up surgical diagnosis. The diagnostic, suspicious/atypical/suggestive, and nondiagnostic rates (%) for the head and neck FNAs were 83 versus 86, 10 versus 13, and 7 versus 1 in PGFNA group versus USGFNA group, respectively. Surgical follow‐up specimens were found in 50 PGFNAs versus 35 USGFNAs. The true‐positive, true‐negative, false‐positive, and false‐negative rates (%) were 92, 2, 2, and 4 versus 80, 17, 3, and 0 in PGFNAs versus USGFNAs, respectively. The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy were 96, 50, 98, 33, and 94% in PGFNAs versus 100, 86, 97, 100, and 97% in the USGFNA group, respectively. This study also shows increased FNAs of thyroid and salivary glands and other smaller nonpalpable lesions with ultrasound guidance. USGFNAs performed by a cytopathologist could significantly improve the specificity and NPV (P = 0.04) while preserving virtually the same excellent sensitivity and PPV as those of PGFNAs. With ultrasound guidance, a cytopathologist will be able to perform FNAs in smaller, nonpalpable lesions and target complex lesions with confidence and accuracy, thus achieving a better outcome. Diagn. Cytopathol. 2010. © 2010 Wiley‐Liss, Inc.
Added value, decreased cost: The evolving role of the cytotechnologist for preliminary screening and triage of thyroid aspirates
Authors: Wotruba Angelean L. , Stewart Jimmie , Scheberl Thomas , Selvaggi Suzanne M.
Published: October 2010

Immediate adequacy assessment for thyroid fine‐needle aspirations (FNAs) is standard practice in many cytopathology laboratories. A pathologist is usually present for these time consuming assessments. The purpose of this 5 month study (January 2008–May 2008) was to show that cytotechnologists can accurately provide the majority of immediate adequacy assessments for thyroid FNAs, saving both time and money for pathologists, clinicians, and patients. The study consisted of 167 thyroid nodule FNAs performed in twice weekly thyroid FNA clinics. A comparison was made of the immediate assessments by five participating cytotechnologists and the preliminary and final diagnoses by three pathologists. The cytotechnologist prepared the slides, assessed the air‐dried Hema‐Diff™ stained slides for adequacy, and the pathologist viewed the slides remotely via real‐time video streaming. Results were recorded in an Excel spreadsheet. There was a discordance rate of 1.2% when comparing the cytotechnologist's adequacy interpretation and the pathologist's preliminary diagnosis; both clinically insignificant. By cytotechnologist assessment, 79.0% of the cases were benign and 6.6% were nondiagnostic. 14.4% of the cases were assessed as cellular nodule or neoplastic lesion; all requiring pathologist's preliminary diagnosis. Utilizing a cytotechnologist to provide adequacy, instead of a pathologist, saved $464.10/case (2.38 passes/case) based on current gross technical and professional charges. On the basis of our findings, cytotechnologists can accurately provide immediate onsite adequacy assessments for thyroid nodule FNAs. Affording cytotechnologists the opportunity to preliminarily assess FNAs for adequacy also creates a new role in the laboratory. Furthermore, cost‐savings are realized for patients and the health care system. Diagn. Cytopathol. 2011. © 2010 Wiley Periodicals, Inc.
Clinicopathological study of Papanicolaou (Pap) smears for diagnosing of cervical infections
Authors: Bukhari Mulazim Hussain , Majeed Mudassar , Qamar Samina , Niazi Shahida , Syed Sadaf Zahra , Yusuf Ahmed Wasim , Yusuf Noshin Wasim
Published: October 2010

Cervical infections are not uncommon in our population especially in young and sexually active women. One thousand samples of married women, aged between 20 and 70 years, were studied by conventional Papanicolaou smears. These samples were examined in the Department of Pathology, King Edward Medical University, Lahore from January 2007 to June 2009. Only cases without (pre)neoplastic cytology were included. Six types of infections were diagnosed cytologically. The overall frequency of normal, inadequate, neoplastic, and infective smears was 50%, 1.8%, 10.2%, and 38.3%, respectively. Most of the patients (67%) were in the reproductive age group with mean age 34.7 ± 2.6 years. The commonest clinical sign seen in 354/383 (92%) cases and symptom in (349/383; 91%) cases were vaginal discharge and pruritis vulvae. Among the infective smears, 290 cases (75.7%), the cytologic diagnosis was nonspecific inflammation. Most of these 290 smears contained clue cells (indicating Gardnerella infection) and a lack of lactobacilli. Such smears are predominant in patients suffering from bacterial vaginosis (BV). Twenty‐eight smears (7.3%) were positive for Trichomonas vaginalis, 27 cases (7%) were smears with koilocytic change pathognomonic of human papilloma virus infection. Twenty‐five smears (6.5%) were positive for fungal infection. Seven cases (1.8%) were diagnosed as herpes simplex virus infection. Finally, there were six cases (1.5%) with atrophic vaginitis. We conclude that the cervical smear is well suited for diagnosing cervical infections. It is clear that Gardnerella, known to be associated with bacterial vaginosis, is a major problem in our Pakistani population. Diagn. Cytopathol. 2012. © 2010 Wiley Periodicals, Inc.
Cytology of a giant adult‐type rhabdomyoma of the tongue
Authors: Etit Demet , Bayol Umit , Cumurcu Suheyla , Erdogan Isin , Tan Ayca
Published: October 2010

Adult rhabdomyoma is a rare primary benign tumour of striated muscle origin that almost exclusively presents in the head and neck region with predilection for male. We herein report a case of an adult rhabdomyoma in a 67‐year‐old male with cytologic features. The lesions was located in the tongue extended to the left parapharyngeal region. We discuss the cytological findings with a brief review of the literature on this entity. Diagn. Cytopathol. 2010. © 2010 Wiley‐Liss, Inc.