bluuebunny/crossref_metadata_2025 huggingface dataset:
A Reusable Capillary Flow-Driven Microfluidic System for Abscisic Acid Detection Using a Competitive Immunoassay
Authors: Domingues Cristiana , Rodrigues Marta S. C. , Condelipes Pedro G. M. , Fortes Ana Margarida , Chu Virginia , Conde João Pedro
Published: January 2025

Point-of-care (PoC) devices offer a promising solution for fast, portable, and easy-to-use diagnostics. These characteristics are particularly relevant in agrifood fields like viticulture where the early detection of plant stresses is crucial to crop yield. Microfluidics, with its low reagent volume requirements, is well-suited for such applications. Self-driven microfluidic devices, which rely on capillary forces for fluid motion, offer an attractive alternative by eliminating the need for external pumps and complex fluid control systems. However, traditional microfluidic prototyping materials like polydimethylsiloxane (PDMS) present challenges due to their hydrophobic nature. This paper presents the development of a reusable, portable, capillary-driven microfluidic platform based on a PDMS-PEG (polyethylene glycol) copolymer designed for the rapid low-cost detection of abscisic acid (ABA), a key biomarker for the onset of ripening of non-climacteric fruits and drought stress in vines. By employing passive fluid transport mechanisms, such as capillary-driven sequential flow, this platform enables precise biological and chemical screenings while maintaining portability and ease of use. A simplified field-ready sample processing method is used to prepare the grapes for analysis.
High-Performance Optical Fiber Displacement Sensor with Extended Linear Range and Sensitivity
Authors: Zubia Gorka , Zubia Joseba , Amorebieta Josu , Aldabaldetreku Gotzon , Zubia Asier , Durana Gaizka
Published: January 2025

Optical Fiber Displacement Sensors (OFDSs) provide several advantages over conventional sensors, including their compact size, flexibility, and immunity to electromagnetic interference. These features make OFDSs ideal for use in confined spaces, such as turbines, where direct laser access is impossible. A critical aspect of OFDS performance is the geometry of the fiber bundle, which influences key parameters such as sensitivity, range, and dead zones. In this work, we present a streamlined design methodology for azimuthally symmetric OFDSs to improve the linear range of these sensors. The most effective configuration we propose is the pentafurcated bundle, which consists of a central transmitting fiber surrounded by four concentric rings of fibers with different radii. Our experimental results show that the pentafurcated designs increase both the range—up to 10.5 mm—and the sensitivity of the sensor—2mm−1—while minimizing the dead zone of the sensor (2.5 mm), allowing accurate measurements even at very short distances
Anti-Migratory Activity of Brazilin Chemodiversification on Breast Cancer Cells
Authors: Hernández-Moreno Alberto , Nava-Tapia Dania A. , Zuñiga-Eulogio Miriam D. , Bello-Martínez Jorge , Olea-Flores Monserrat , Hernández-Moreno Tadeo , Ordoñez Mario , Zacapala-Gómez Ana E. , Mendoza-Catalán Miguel A. , Navarro-Tito Napoleón
Published: January 2025

Breast cancer is the most common and the leading cause of cancer death in women worldwide; treating invasive breast carcinomas is challenging due to the side effects of chemotherapeutics. Compounds isolated from natural sources have been proposed as potential molecules for cancer therapy; for instance, the homoisoflavonoid brazilin has shown pharmacological properties, including anti-tumoral and anti-inflammatory activities. In this study, we isolated brazilin from the heartwood of Haematoxylum brasiletto; then, we performed a semi-synthesis by adding three methyl or acetyl groups to the core structure of brazilin. We confirmed the identity of brazilin and its derivatives by spectroscopic data (1H NMR and 13C NMR) and measured their purity by optical rotation. Then, we analyzed the effects of brazilin and its derivatives in three mammary gland-derived cell lines: the TNBC MDA-MB-231, the ERα(+) MCF7, and the non-tumorigenic MCF10A. We evaluated the cell viability by MTT assays, cell migration by wound-healing assays, and focal adhesion kinase (FAK) activation by Western blot. Regarding biological assays, the MTT assay showed that these compounds showed cytotoxic effects on the MCF7 and MDA-MB-231 breast cancer cells at 20 µM but was not toxic in non-tumorigenic MCF10A mammary epithelial cells. Specifically, the greatest effects found from treatment with the compounds were in the MDA-MB-231 cell line, where the IC50 of brazilin was 49.92 μM, and for MCF7, the brazilin-(OAc)3 was 49.97 μM. These effects were dose- and time-dependent, as well as being associated with a decrease in the levels of cell migration and FAK activation.
Evolving Roles for International Social Work in Addressing Climate Change
Authors: Nagoshi Julie L. , Pillai Vijayan K. , Salehin Mashooq A.
Published: January 2025

Global warming and ozone layer depletion signal the onset of climate change, a “slow-onset” disaster exacerbating poverty and social inequality. Addressing this requires global cooperation, as exemplified by the United Nations’ Sustainable Development Goals (SDGs), particularly SDG 13, which focuses on climate action. Mitigation measures include reducing greenhouse gas emissions, transitioning to clean energy, and enhancing community resilience. Social workers play a crucial role in climate change adaptation, engaging in community resilience, advocacy, and policy influence. Their work spans individual counseling, social protection, and addressing environmental refugee crises. As climate change impacts intensify, social workers must expand their roles internationally, advocating for human rights, social justice, and disaster risk reduction. Human rights frameworks guide social workers in addressing climate-related health and social inequalities, emphasizing empowerment and equity. International social workers contribute significantly to disaster response, pandemic recovery, and community resilience, advocating for vulnerable populations and promoting sustainable development. Their evolving role underscores the need for a comprehensive, transnational approach to social protection, ensuring equitable access to resources and fostering a more just and resilient global community.
Enhancing Cognitive Navigation for Sustainable Campus Environments: Insights from Path Network Evaluation Surrounding Egyptian Universities
Authors: Touliabah Eman H. E. , Mori Suguru , Nomura Rie
Published: January 2025

Cognitive navigation, crucial in architectural and urban planning, involves the mental processes individuals use for navigation within spatial environments. This study investigates the relationship between a path network design and cognitive navigation experiences surrounding closed-access university campuses, focusing on design optimization’s impact on user experience and its alignment with Sustainable Development Goals (SDGs). Employing a mixed-methods approach, the research encompasses site visits, quantitative surveys of 120 randomly selected cases, and qualitative surveys of 60 cases from universities in Egypt. Findings reveal significant factors influencing path choices, such as directness and clear signage, with 77% of participants encountering navigation obstacles. Public universities prioritize clear pathways, while private institutions emphasize scenic views and landmarks. The study highlights the moderate integration of cultural and contextual elements and identifies key challenges, including traffic congestion and signage difficulties. Conclusions underscore the importance of user-centered design, infrastructure improvements, cultural sensitivity, and dynamic campus environments in optimizing path networks. This research aligns with SDGs by promoting good health and well-being (SDG 3), quality education (SDG 4), innovation and infrastructure (SDG 9), sustainable cities and communities (SDG 11), climate action (SDG 13), and life on land (SDG 15), providing valuable insights for enhancing navigable, sustainable, and intuitive educational spaces.
Can Reuse of Stormwater Detention Pond Water Meet Community Urban Agriculture Needs?
Authors: Ortiz Estenia , Mayr Mejia Adriana , Borely Emma , Schauer Liam , Young Green Lena , Trotz Maya
Published: January 2025

Urbanization and population growth in coastal communities increase demands on local food and water sectors. Due to this, urban communities are reimagining stormwater pond infrastructure, asking whether the stormwater can be used to irrigate food and grow fish for local consumption. Studies exploring this feasibility are limited in the literature. Driven by a community’s desire to co-locate community gardens with stormwater pond spaces, this research monitored the water quality of a 23.4-hectare stormwater pond located in East Tampa, Florida over one year using the grab sample technique and compared the results with U.S. Environmental Protection Agency (EPA) reuse recommendations, EPA national recommended water quality criteria for aquatic life, and human health. pH and conductivity levels were acceptable for irrigating crops. Heavy metal (arsenic, cadmium, copper, lead, and zinc) concentrations were below the maximum recommended reuse levels (100, 10, 200, 5000 and 2000 µg/L, respectively), while zinc and lead were above the criteria for aquatic life (120 and 2.5 µg/L, respectively). E. coli concentrations ranged from 310 to greater than 200,000 MPN/100 mL, above the 0 CFU/100 mL irrigation requirements for raw food consumption and 200 CFU/100 mL requirements for commercial food processing. Synthetic organic compounds also exceeded criteria for human health.
Application of Developing Artificial Intelligence (AI) Techniques to Model Pan Evaporation Trends in Slovak River Sub-Basins
Authors: Novotná Beáta , Cviklovič Vladimír , Chvíla Branislav , Minárik Martin
Published: January 2025

The modeling of pan evaporation (Ep) trends in Slovak river sub-basins was conducted using advanced artificial intelligence (AI) techniques algorithms to accurately calculate evaporation rates based on daily climate data from 2010 to 2023 across eight sub-basins in the Slovak Republic. The AI modeling results reveal that the Bodrog, Hornád, Ipeľ, Morava, Slaná, and Váh river basins are experiencing increases in evaporation, while the Dunaj and Hron rivers show declining trends. This divergence may indicate varying ecological factors influencing the evaporation dynamics of each river. A comprehensive set of 28 machine learning (ML) and deep learning (DL) models was employed, including ML techniques such as linear regression, tree-based, support vector machines (both with and without kernels), ensemble, and Gaussian process methods; as well as DL approaches like neural networks (narrow, medium, wide, bilayered, and trilayered). Among these, stepwise linear regression provided the most optimal fit. The minimum redundancy maximum relevance (mRMR) method was utilized for feature selection to balance relevance and redundancy effectively. The results suggest that emphasizing relative humidity (RH) and minimum temperature (tmin) significantly enhances accuracy, highlighting the critical roles of these factors in modeling pan evaporation trends. The results offer precise evaporation analyses to improve water management and lessen scarcity.
Alkali Pretreatment of Lignocellulose Feedstock Improves Morphological Structure and Biomethane Yield
Authors: Madyira Daniel M. , Olatunji Kehinde O.
Published: January 2025

This study investigates the effects of NaOH pretreatment on the microstructural distribution and biomethane released from Xyris capensis. Xyris capensis was pretreated with NaOH using 1, 2, 3, 4, and 5% w/w concentrations for 60, 45, 30, 20, and 15 min of exposure time, respectively, at a 90 °C autoclave temperature. The impacts of the pretreatment technique on microstructural arrangement, crystallinity, and functional groups were examined with a scanning electron microscope (SEM), X-ray diffraction, and Fourier transform infrared (FTIR), respectively. NaOH-pretreated and untreated feedstocks were digested at the laboratory scale at a mesophilic temperature (37 ± 2 °C) for 35 days for their biomethane potential. It was discovered from the SEM analysis that NaOH pretreatment affects the microstructural arrangement of Xyris capensis, and the sample with the longer exposure time is the most affected. The results of XRD and FTIR also indicated that NaOH pretreatment lowered the crystallinity of the feedstock and significantly influenced the functional groups at varying degrees. Biomethane yield was recorded to be 258.68, 287.80, 304.02, 328.20, 310.20, and 135.06 mL CH4/gVSadded, representing 91.53, 113.09, 125.10, 143.00, and 129.68% more increases than the untreated feedstock. It was discovered that the optimum biomethane generation was achieved when 4% w/w of NaOH concentration was utilized for 20 min. This study shows that a higher NaOH concentration with a shorter retention time is more suitable for Xyris capensis. This pretreatment method can improve the biomethane yield of Xyris capensis and can be investigated for industrial applications and its use on other lignocellulose feedstocks, especially energy grasses.
Sustainable Water Quality Evaluation Based on Cohesive Mamdani and Sugeno Fuzzy Inference System in Tivoli (Italy)
Authors: Bellini Francesco , Barzegar Yas , Barzegar Atrin , Marrone Stefano , Verde Laura , Pisani Patrizio
Published: January 2025

Clean water is vital for a sustainable environment, human wellness, and welfare, supporting life and contributing to a healthier environment. Fuzzy-logic-based techniques are quite effective at dealing with uncertainty about environmental issues. This study proposes two methodologies for assessing water quality based on Mamdani and Sugeno fuzzy systems, focusing on water’s physiochemical attributes, as these provide essential indicators of water’s chemical composition and potential health impacts. The goal is to evaluate water quality using a single numerical value which indicates total water quality at a specific location and time. This study utilizes data from the Acea Group and employs the Mamdani fuzzy inference system combined with various defuzzification techniques as well as the Sugeno fuzzy system with the weighted average defuzzification technique. The suggested model comprises three fuzzy middle models along with one ultimate fuzzy model. Each model has three input variables and 27 fuzzy rules, using a dataset of nine key factors to rate water quality for drinking purposes. This methodology is a suitable and alternative tool for effective water-management plans. Results show a final water quality score of 85.4% with Mamdani (centroid defuzzification) and 83.5% with Sugeno (weighted average defuzzification), indicating excellent drinking water quality in Tivoli, Italy. Water quality evaluation is vital for sustainability, ensuring clean resources, protecting biodiversity, and promoting long-term environmental health. Intermediate model evaluations for the Mamdani approach with centroid defuzzification showed amounts of 72.4%, 83.4%, and 92.5% for the first, second, and third fuzzy models, respectively. For the Sugeno method, the corresponding amounts were 76.2%, 83.5%, and 92.5%. These results show the precision of both fuzzy systems in capturing nuanced water quality variations. This study aims to develop fuzzy logic methodologies for evaluating drinking water quality using a single numerical index, ensuring a comprehensive and scalable tool for water management.
Assessing Pollution with Heavy Metals and Its Impact on Population Health
Authors: Saliba Youssef , Bărbulescu Alina
Published: January 2025

Pollution is one of the most important issues currently affecting the global population and environment. Therefore, determining the zones where stringent measures should be taken is necessary. In this study, Principal Component Analysis (PCA), Factor Analysis (FA), and t-distributed Stochastic Neighbor Embedding (t-SNE) were utilized for dimensionality reduction and clustering of data series containing the concentration of 10 heavy metals collected at 14 locations. The Hazard Quotient (HQ) and Hazard Index (HI) were utilized to determine the non-carcinogenic risk to the population in the studied zones. The highest concentrations of metals in the samples were those of Fe, Zn, Mn, and Cr. PCA indicated that Fe and Zn (Co and Cd) had the highest contribution on the first (second) Principal Component (PC). FA showed that the three-factor model is adequate for explaining the variability of pollutant concentrations. The factor loadings revealed the strength of association between variables and factors, e.g., 0.97 for Zn, 0.83 for Cr, and 0.99 for Co. HQ for ingestion, HQing, was the highest for Fe (between 6.10 × 10−5 and 2.57 × 10−4). HQ for inhalation, HQinh, was the biggest for Mn (from 1.41 × 10−3 to 1.95 × 10−3). HI varied in the interval [0.172, 0.573], indicating the absence of a non-carcinogenic risk. However, since values above 0.5 were determined at four sites, continuous monitoring of the pollution in the sampling locations is necessary.
The Dissemination of Rift Valley Fever Virus to the Eye and Sensory Neurons of Zebrafish Larvae Is Stat1-Dependent
Authors: ter Horst Sebastiaan , Siekierska Aleksandra , De Meulemeester Ann-Sofie , Cuvry Arno , Cools Laura , Neyts Johan , de Witte Peter , Rocha-Pereira Joana
Published: January 2025

The Rift Valley fever virus (RVFV) causes haemorrhagic fever, encephalitis, and permanent blindness and has been listed by the WHO as a priority pathogen. To study RVFV pathogenesis and identify small-molecule antivirals, we established a novel In Vivo model using zebrafish larvae. Pericardial injection of RVFV resulted in ~4 log10 viral RNA copies/larva, which was inhibited by the antiviral 2′-fluoro-2′-deoxycytidine. The optical transparency of the larvae allowed detection of RVFVeGFP in the liver and sensory nervous system, including the optic tectum and retina, but not the brain or spinal cord. Thus, RVFV-induced blindness likely occurs due to direct damage to the eye and peripheral neurons, rather than the brain. Treatment with the JAK-inhibitor ruxolitinib, as well as knockout of stat1a but not stat1b, enhanced RVFV replication to ~6 log10 viral RNA copies/larva and ultra-bright livers, although without dissemination to sensory neurons or the eye, thereby confirming the critical role of stat1 in RVFV pathogenesis.
Efficiency of Graphene Quantum Dots in Water Contaminant Removal: Trends and Future Research Directions
Authors: Rodríguez-Caicedo Juliana P. , Joya-Cárdenas Diego R. , Corona-Rivera Miguel A. , Saldaña-Robles Noé , Damian-Ascencio Cesar E. , Saldaña-Robles Adriana
Published: January 2025

This review explores the efficiency and mechanisms of GQDs in removing contaminants from water, emphasizing their potential for environmental applications. GQDs possess unique physicochemical properties, such as a high surface area, tunable photoluminescence, and strong adsorption capacities, which enable the effective removal of diverse contaminants, including heavy metals, organic compounds, and dyes. Their electron-hole separation efficiency and functionalizability enhance their reactivity and selectivity. Notable findings include the integration of GQDs into advanced nanocomposites and supramolecular networks, significantly improving their adsorption and catalytic performance. However, challenges such as variability in synthesis methods, stability under environmental conditions, and the environmental impact of GQDs remain. Addressing these limitations and understanding the interaction mechanisms between GQDs and contaminants are critical. Future research should prioritize scalable green synthesis techniques, long-term environmental assessments, and optimized functionalization strategies to establish GQDs as a sustainable solution in water purification technologies.
Impact of Land Use Change on Lake Pollution Dynamics: A Case Study of Sapanca Lake, Turkey
Authors: Ozdemir Serkan , Celebi Ahmet , Dede Gulgun , Maghrebi Mohsen , Danandeh Mehr Ali
Published: January 2025

Modeling non-point source pollution dynamics in inland lake basins is essential for safeguarding water quality, maintaining ecosystem integrity, protecting public health, and advancing long-term environmental sustainability. This study explores non-point pollution dynamics in the Sapanca Lake basin, Turkey, in association with the basin’s land use, land cover, hydrology, pollutant sources, and water quality parameters. The required data were gathered via a three-year monitoring program, which was carried out at 12 sampling stations around the lake, as well as using the collecting field measurements and GIS databases. Stepwise multiple regression analysis was employed to determine the best relation between non-point pollutants and land features. The results showed that urbanization and population density have significant correlations with the total nitrogen (TN) and total phosphorus (TP) in the study areas. Rivers crossing pristine areas, such as forests and uncultivated lands, demonstrated better water quality, thereby positively contributing to the lake ecosystem conservation. The highest nutrient loads were observed in streams that flow through highly urbanized sub-basins, followed by predominantly agricultural areas. This is likely due to runoff from urban environments, leaching from cultivated land, and contributions from livestock and tourism facilities. Conversely, densely forested regions exhibited the lowest levels of nutrient loads, highlighting their capacity for nutrient retention. The peak levels of non-point source pollution (TN = 5.22 mg/L and TP = 0.53 mg/L) were recorded in catchments with the highest degree of urbanization, whereas the lowest values (TN = 0.28 mg/L and TP = 0.04 mg/L) were found in the least urbanized areas. These findings emphasize that nutrients primarily impact water quality because of increasing urban and agricultural activities, while forested land plays a vital role in preserving lake water quality. To ensure sustainable water quality in lake basins, it is essential to strike a careful balance between protective measures and utilization policies, prioritizing conservation efforts.
Site-Specific Hydrogeological Characterization for Radiological Safety: Integrating Groundwater Dynamics and Transport
Authors: Kim Soo-Gin , Kwon Hong-Il , Yoon Jeoung-Seok , Kim Chan-Hong , Heo Hyo , Lee Chung-Mo
Published: January 2025

The radiological impact of radionuclide transport via groundwater pathways at the Wolsong Low- and Intermediate-Level Waste (LILW) Disposal Center was estimated by considering site-specific characteristics, including hydrogeology, geochemistry, and land use. Human intrusion scenarios, such as groundwater well development, were analyzed to evaluate potential pumping volumes and radionuclide migration pathways. Particular attention was given to the hydrological and geochemical aspects of radionuclide transport, with a focus on local aquifer heterogeneity, flow dynamics, and interactions with engineered barriers and surrounding rock formations that delay radionuclide migration through sorption and other retention mechanisms. Sorption coefficients (Kd), calibrated using site-specific geochemical data, were incorporated to ensure realistic modeling of radionuclide behavior. A hierarchical approach integrating scenario screening, particle tracking techniques, and mass transfer modeling was employed. Numerical simulations using FEFLOW ver. 7.3 and GoldSim ver. 14.0 software provided insights into near-field and far-field transport phenomena under well pumping conditions. The results revealed distinct spatial flux behaviors, where carbon-14 (14C) dominated near-field flux due to its high inventory, while technetium-99 (99Tc) emerged as the primary dose contributor in the far-field flux, owing to its anionic nature and limited sorption capacity. Additionally, under high-pH conditions near concrete barriers, cellulose degradation into isosaccharinic acid was identified, enhancing radionuclide mobility through complex formation. These findings underscore the importance of site-specific sorption and speciation parameters in safety assessment and highlight the need for accurate geochemical modeling to optimize waste placement and ensure long-term disposal safety. The outcomes provide valuable insights for optimizing waste placement and contribute to the development of evidence-based safety strategies for long-term performance assessment.
Unveiling the Multi-Dimensional Vulnerabilities of Flood-Affected Communities in Khyber Pakhtunkhwa, Pakistan
Authors: Ullah Wahid , Dong Haijun , Shah Ashfaq Ahmad , Xu Chong , Alotaibi Bader Alhafi
Published: January 2025

Climate-induced migration is increasingly affecting communities, disrupting livelihoods, and intensifying socio-economic inequalities, particularly in disaster-prone regions. Despite the prevalence of recurring flood hazards, there remains limited research on the multi-dimensional impacts of migration particularly in socio-culturally sensitive and resource-constrained settings like Khyber Pakhtunkhwa (KPK), Pakistan. This study seeks to bridge this gap by exploring the post-migration challenges of flood-affected communities in District Nowshera. Using a qualitative methodology, we conducted in-depth interviews with 25 diverse key informants. The study results revealed profound socioeconomic instability, inadequate access to essential services, and cultural disruptions. Key findings include significant challenges such as inadequate housing, the loss of traditional livelihoods, persistent financial hardships, health issues, and the breakdown of social support networks. Moreover, displaced families face marginalization and language barriers, which hinder integration into host communities, amplifying feelings of isolation and identity loss. Environmental degradation in resettlement areas further intensifies these challenges, prolonging poor living conditions and heightened vulnerability. To address these issues, the study recommends community-based interventions such as developing resilient, culturally appropriate housing, implementing targeted skills training programs to restore livelihoods, promoting climate-smart agricultural practices, and enacting inclusive social policies to promote integration and cohesion to address climate-induced migration in disaster-prone regions.
Traditional ethnic imperatives in a cultural frontier
Authors:   Department of Foreign Languages, V.Ya. Kikot' Moscow University of the Ministry of Internal Affairs of the Russian Federation, Artabaeva Anzhelika Eduardovna
Published: January 2025

The article analyzes ethnic and cultural issues in modern conditions. Didactic models
focused on educating a special type of personality, designed to protect the state system
either from external enemies or from internal ones, have not lost their relevance
throughout the history of humankind and were the basis of the pedagogical complexes
of the USSR, both in the paramilitary part of Soviet society and in the civilian sector. In
the latter, however, there was no concept of compulsory discipline and order, which
were replaced in everyday life by the concepts of collective interest, duty, and moral
obligation. However, one thing seems obvious: those strata of the population, as well
as the structures of a certain state, which, due to their functional load, play the role of a
stabilizer of social relationships in frontier zones, are formed under the mandatory correcting
and decisive impact of traditional ethnic norms and standards of education. As
the experience of oppositional interactions between military and security forces of various
societies, and, moreover, those of a diff erent confessional and ethnic nature, shows, it
is the complexes of didactics, related to the customs of protection and forceful influence
on the opponent, that lead to the formation of similar moral and ethical imperatives and
to the creation of ways to possible dialogue and mutual understanding.
Characteristics of septoplasty in patients following unilateral cleft lip and palate repair
Authors: Gabuev I. K. , Vissarionov V. A. , Mustafaev M. S. , Mustafaeva S. M. , Tarchokova E. M.
Published: January 2025

Relevance. Postoperative scarring from primary and secondary cheilorhinoplasty procedures often results in impaired nasal breathing and aesthetic deformities. Objective: To enhance regeneration of damaged nasal mucosa and prevent recurrent nasal breathing dysfunction caused by secondary scarring and septal displacement during septoplasty, through the use of protective concealment.

Description of clinical case. This article presents a clinical case of surgical treatment in a patient diagnosed with "Congenital complete left-sided cleft of the upper lip, alveolar process, hard and soft palate; status post cheilorhinoplasty and uranostaphyloplasty; deviated nasal septum; and cicatricial deformity of the skin-cartilaginous portion of the nose on the left." After undergoing multiple surgical interventions, the patient displayed a flattened left nasal wing, functional impairments in nasal breathing, and dissatisfaction with the aesthetic appearance of the nose.

Conclusion. Using a platelet-rich plasma membrane during septoplasty can help prevent nasal cicatricial deformities, significantly reducing the risk of postoperative nasal deviations and breathing impairments, ultimately benefiting patient outcomes.
DEVELOPMENT REVIEW OF THE BIDAR BOAT FESTIVAL AS AN EFFORT TO PRESERVE CULTURAL HERITAGE THROUGH THE PENTA-HELIX CONCEPT IN PALEMBANG CITY
Authors: Karo Karo Pelliyezer , Aziz Abdul
Published: January 2025

Sustainable tourism development hinges on robust collaboration among various stakeholders, and the Penta-Helix model—comprising government, business, academics, media, and community—serves as a comprehensive framework to facilitate this cooperation. This research seeks to evaluate the effectiveness of the Penta-Helix concept in the development and sustainability of the Bidar Boat Festival in Palembang City, an annual event that preserves and promotes the cultural heritage of traditional bidar boats. Initiated by the Palembang City Government, the festival not only celebrates regional heritage but also bolsters cultural tourism. Employing a literature study-based approach, this research reviews existing journals and publications to examine the extent of Penta-Helix integration within the festival's organizational framework. Findings indicate that while the application of the Penta-Helix concept has enhanced cooperation across stakeholders, further strengthening and more active participation from each element could amplify the festival’s reach and impact. Future recommendations suggest enhancing collaboration between the involved elements to foster long-term cultural preservation and ensure the festival's continued success as a hallmark of Palembang's cultural identity. By leveraging the Penta-Helix approach, this study contributes to the broader discourse on sustainable tourism and cultural heritage preservation through multi-stakeholder engagement.
Dancing for a Cause: Examining the Role of K-Pop in Mobilizing Youth for Charitable Giving during Ramadan
Authors: Agoes Adrian , Khansa Diva
Published: January 2025

This research investigates the success of the "K-POP Dance Cover Showcase & Charity Event (SxS Ngabuburit Vol. 2)" as a case study within event tourism, focusing on its utilization of Ramadan as a catalyst for charitable giving. Grounded in a participatory approach, the researcher, actively involved in event planning and execution, augmented findings with interviews of the organizing leader. The event, held within a local community, attracted 20 dance groups and 300 spectators, raising Rp. 2.6 million for charity, solely from local participants. K-Pop's global influence transcends entertainment, extending to philanthropic endeavors. The integration of K-Pop with charitable initiatives, especially within a local context, remains underexplored. A participatory approach intertwined with semi-structured interviews was adopted. The researcher's involvement from planning to execution provided first-hand insights, while interviews with the organizing leader unveiled motivations and operational intricacies. Ramadan served as a pivotal driver, harnessing spiritual values to mobilize youth towards charitable acts. The event exemplified communal solidarity and social consciousness, transcending cultural boundaries. Operational insights highlighted strategic alignment with Ramadan's temporal significance, guiding decision-making processes. This study elucidates the success of the "SxS Ngabuburit Vol. 2" event, showcasing how the integration of K-Pop with Ramadan charity initiatives fosters community engagement and philanthropy. Recommendations include leveraging cultural and temporal contexts to maximize impact in future event planning.
Analisis Tingkat Kepuasan Keamanan Penonton Terhadap Crowd Control pada Konser Musik
Authors: Purwantari Niar Vini Annisa
Published: January 2025

Penelitian ini bertujuan untuk mengetahui bagaimana tingkat kepuasan keamanan antara kinerja dan harapan dari pengendalian kerumunan menurut penonton konser musik dengan menggunakan metode CSI (Customer Satisfaction Index). Penelitian ini dilakukan pada konser musik 2023 WOODZ WORLD TOUR [OO-LI] IN JAKARTA dengan sampel sebanyak 340 responden. Teknik pengambilan sampel ini adalah probability sampling, dan teknik pengumpulan data menggunakan kuesioner dan wawancara. Hasil penelitian menunjukkan bahwa (1) strategi pengendalian kerumunan Mecimapro berdasarkan dari empat dimensi pengendalian kerumunan (waktu, ruang, informasi, dan energi), (2) tingkat kepuasan yang menunjukkan konsistensi rasa kepuasan yang dirasakan oleh penonton terhadap kinerja pengendalian kerumunan yang dilakukan oleh promotor.
Evaluation Study of the Joint Movement Strategy “Geber” in Improving the Preservation of Pananjung Pangandaran
Authors: Rizky Fahmi Muhamad , Maryani Enok
Published: January 2025

Cagar Alam Pananjung, located in West Java, is a nature reserve rich in biodiversity and a popular tourist destination. This study evaluates the Joint Movement Strategy (Geber) in conserving this nature reserve through collaboration between the government and the community. A qualitative research method with a descriptive analytical approach was used, relying on literature review from various relevant sources. The study results indicate that the implementation of the Geber strategy faces various challenges and opportunities. The role of the government in coordinating and implementing environmental policies and managing the nature reserve is crucial. However, there is a need to strengthen monitoring mechanisms and law enforcement. Active participation of the local community is also significant in managing the nature reserve through education, training, and empowerment. The study's recommendations include improving coordination between government agencies and monitoring mechanisms, as well as increasing community participation through education and training. The government is also advised to facilitate partnerships with the private sector and non-governmental organisations to support conservation efforts. In conclusion, collaboration between the government and the community is essential to enhance the conservation of Pananjung Pangandaran nature reserve. Effective implementation of the Geber strategy is expected to preserve this nature reserve for the well-being of future generations.
The Level of Interest of Pangkalpinang Residents in The Bukit Pagoda Nusantara Tourist Destination in Sungailiat District, Bangka Regency
Authors: Cahya Jodi , Daffa Muhammad Rifqy , Syawana Dhiyaa , Syahrani Rizkita
Published: January 2025

Pagoda Nusantara Hill is one of the mainstay tourist destinations on Bangka Island. With its theme centered around Chinese culture, Pagoda Nusantara exudes its own unique charm. It can also attract local and foreign tourists. Pagoda Nusantara Hill also carries a religious theme. In addition to its status as a tourist destination, Pagoda Nusantara Hill also serves as a Buddhist place of worship. The natural beauty in the form of hills makes this tourist destination have its own tourist attraction. This study aims to analyze the level of interest that Pangkalpinang residents have in the Bukit Pagoda Nusantara tourist attraction, located in Sungailiat District, Bangka Regency. This research employs a quantitative and descriptive approach to assess the level of tourist interest in Bukit Pagoda Nusantara tourist destinations. The data is obtained based on the results of filling out a questionnaire using Google Forms.  The link from the Google form is distributed to Pangkalpinang residents who have visited the Bukit Pagoda Nusantara tourist destination via WhatsApp. The validity of the data obtained in the form of the author writing a caption on the Google form link in the form of “Only for Pangkalpinang residents who have visited Bukit Pagoda Nusantara.”.  Based on the results of the Google form, 37 respondents were obtained who filled in several questions that had been prepared by the author. The results obtained from this study state that the level of interest of Pangkalpinang residents in the Bukit Pagoda Nusantara tourist destination is 47% (low level).  Critics and suggestions for Bukit Pagoda Nusantara are that the most important thing is improving road access for visitors to make it easier to access the tourist attractions. In addition, it is hoped that the staff can maintain and repair facilities that are damaged or that are no longer suitable for use by visiting tourists. This will enhance the interest of tourists in visiting the area.
The Strategy for Developing Siguntang Hill as A Pilgrimage Tourist Attraction in Palembang City
Authors: Mulyani Irma , Nurbaeti  , Ingkadijaya Rahmat , Permatasari Mustika , Aldora Mega
Published: January 2025

Siguntang Hill is a small hill or the highest point in Palembang City with an altitude of 26 meters above sea level. It has historical significance from the royal period found in Palembang City and has various potential as a pilgrimage tour because there are 7 tombs located there. However, the condition of the tombs has deteriorated, and many buildings are not suitable for visiting. The purpose of this research is to review and analyze the management and development strategies of tourist attractions in Siguntang Hill as pilgrimage tourism. The research method used is a qualitative method with a descriptive approach, with data collection techniques in the form of documentation studies, observations, and interviews. The results of the study explain that the strengths of Bukit Siguntang include its central location in the city, accessibility via various transportation fleets, beautiful and cool panorama, and the presence of a King's Tomb which is an icon on Siguntang Hill. The weaknesses include the poor condition of the tombs, lack of human resources in the field of tourism, and limited physical resources for the development and management of facilities at Siguntang Hill. The opportunities include the support of the central government to make Siguntang Hill more attractive, hosting the Siguntang festival activities held regularly every year, and renovations to change the image of Siguntang Hill into a pleasant place to visit. The threats include the lack of dominance of pilgrimage tourism activities at Siguntang Hill, the emergence of competitors as tourist destinations in Palembang City, and the condition of the tombs eroded by time. Bukit Siguntang has significant potential as seen from the SWOT (IFAS and EFAS) analysis, with an IFAS matrix value of 1.7 and an EFAS matrix value of 1.3.
Numerical analysis of flexural behavior of sandwich beams using the FGM approach
Authors: Hichem Belaid , Mohammed Himeur , Hassina Ziou
Published: January 2025

Analytical modeling to predict the flexural behavior of sandwich beams using a triangular finite element model, the Triangular Plate Finite Element with Airy Function (TPAF).  The originality of this model lies in the use of the deformation approach, which comprises three nodes and three degrees of freedom per node (one translation Wi and two rotations θxi and θyi). The main aim of this work is to validate the model by comparison with other solutions, in particular by means of an analytical prediction based on layer theory and the results obtained using CSB software. The originality of this study lies in the fact that the mechanical properties vary according to an exponential function along the height of the FGM section and remain constant in the other parts of the different composite sections. Tabular and graphical results are presented to illustrate the impact of deffrents, such as geometric factors (thickness configurations and length/thickness ratios), as well as boundary conditions and loads, on the static behavior of the beam.
Periodontite e Doença de Alzheimer: uma revisão da literatura
Authors: Tostes Tiago Souza Pinto , Villela Erika Veríssimo , Mitidieri Fernanda
Published: January 2025

A Doença de Alzheimer é uma doença multifatorial e vários mecanismos envolvidos já foram descritos. Agentes microbianos, incluindo patógenos periodontais, surgiram recentemente com importante papel no desenvolvimento de demências e uma série de estudos estabelece uma relação entre a resposta do organismo à periodontite crônica com o desenvolvimento da Doença de Alzheimer e a perda cognitiva. Considerando que disfunções e acúmulo de proteínas tau e a ativação de células da micróglia, essenciais para a neuroinflamação, ocorrem quase que simultaneamente à colonização de patógenos periodontais no encéfalo, o presente estudo teve como objetivo, por meio de revisão integrativa da literatura, relacionar a má higiene oral e a periodontite com o risco de desenvolvimento e progressão de demências, com enfoque na Doença de Alzheimer. Para tanto, foi realizada uma revisão da literatura na base de dados Medline por meio da Biblioteca Virtual de Saúde. A princípio, foram encontrados 864 artigos, dos quais foram selecionados 11 após o processo de seleção. Os resultados mostraram uma forte correlação entre a periodontite e o surgimento ou o agravamento da Doença de Alzheimer, com a principal bactéria relacionada à periodontite, seu lipopolissacarídeo e a gingipaína sendo encontrados no cérebro da maioria dos pacientes com Doença de Alzheimer. Reforça-se então a importância dos cuidados que levam a uma boa saúde bucal, evitando a doença periodontal, sobretudo na população idosa, como forma de minimizar possíveis danos neurológicos.
Córtex órbito-frontal e alterações do comportamento: uma revisão integrativa da literatura
Authors: Silva Ayalle Thamara da , Irineu Aline Keuly , Santana Artur Negromonte , Moreira Filho Claudio Ramos , Ricardo Davi Guedes , Duarte Everaldo , Oliveira Gabriel Varjal Correa de , Siqueira José Arthur Guedes , Santos Lucas Daniel dos , Marques Matheus Laurindo , Menezes Wellington Freitas de , Barros André Luiz de Souza , Beltrão Raphaelle Lima de Almeida
Published: January 2025

O córtex cerebral, especialmente o córtex órbito-frontal (COF), é essencial para o processamento sensorial, controle motor e funções psíquicas superiores, como integração sensorial, avaliação de riscos/recompensas e regulação do comportamento social e emocional. Alterações estruturais e funcionais no COF estão associadas a transtornos psiquiátricos, como ansiedade, bipolaridade e psicopatia. A redução volumétrica do COF em indivíduos com dificuldades de regulação emocional evidencia sua relevância no equilíbrio comportamental e emocional. Analisar as bases neuroanatômicas e funcionais do COF, identificando suas funções e correlações clínicas, além de compreender o impacto de alterações estruturais e funcionais no comportamento humano e nos transtornos psiquiátricos. Foi realizada uma revisão de literatura em novembro de 2024, na base MEDLINE, com os descritores “orbitofrontal cortex", “behavior” e “changes”, associados pelo operador booleano “AND.” Dos 2824 artigos encontrados, foram incluídas publicações entre 2012 e 2024, com texto completo em inglês, abordando ‘‘córtex pré-frontal’’, ‘‘depressão’’, ‘‘ansiedade’’, ‘‘tomada de decisão’’, ‘‘comportamento social’’ e ‘‘cognição’’ no campo prognóstico. Após exclusões, 21 estudos foram analisados. O COF, composto pelas regiões dorsolateral e orbitofrontal, é crucial para funções executivas, avaliação de riscos/recompensas e regulação emocional. Lesões nessa área causam impulsividade, agressividade e dificuldades de adaptação. Sua redução volumétrica está ligada a transtornos emocionais e maior predisposição psiquiátrica. O COF é vital para a regulação emocional e social. Alterações estruturais e funcionais estão associadas a transtornos psiquiátricos, destacando a importância de terapias personalizadas e pesquisas sobre neuroplasticidade e intervenções.
Resistência à leptina pela obesidade: efeitos na produção de testosterona e saúde metabólica masculina
Authors: Brito Alex Oliveira , Lemos Arthur de Melo , Melo Diogo Nunes , Teixeira Gabriel Maia , Torres Iasmin Ketlin Brandão e , Souza Leon Pereira de , Soáres Nathalia Oliveira , Rodrigues Júnior Valdir Antônio
Published: January 2025

A leptina, hormônio responsável pelo controle do apetite e metabolismo energético, apresenta uma sinalização prejudicada em indivíduos obesos, o que leva à resistência à leptina. Esse fenômeno impacta negativamente a produção de testosterona e a saúde metabólica masculina, favorecendo o desenvolvimento de disfunções endócrinas e metabólicas. Para tanto, procede-se a uma revisão de literatura de artigos selecionados nas bases PubMed, Scopus e Web of Science, com foco nos efeitos da resistência à leptina sobre a produção de testosterona e a saúde metabólica masculina. O estudo analisou 23 artigos relevantes com critérios específicos de inclusão e exclusão. Desse modo, observa-se que a obesidade induz resistência à leptina, o que resulta em disfunções no controle do apetite, metabolismo energético e aumento da inflamação sistêmica. Esse processo compromete a produção de testosterona, afetando a função testicular e desencadeando problemas como diminuição da libido, massa muscular e saúde metabólica. O que permite concluir que a resistência à leptina, característica da obesidade, tem impacto negativo na produção de testosterona e saúde metabólica. Estratégias terapêuticas, como a perda de peso e exercícios físicos, são eficazes para restaurar a sensibilidade à leptina e melhorar a função hormonal, prevenindo doenças metabólicas associadas.
Análise in silico das proteínas e genes com potencial envolvimento nos transtornos depressivos e ansiosos nas condições pós-COVID
Authors: Alvarenga Flávio dos Santos , Zetum Aléxia Stefani Siqueira , Casotti Matheus Correia , Barbosa Karen Ruth Michio , Guaitolini Yasmin Moreto , Louro Iúri Drumond , Meira Débora Dummer
Published: January 2025

Após o período de infecção pelo SARS-CoV-2, constatou-se o aumento de indivíduos com diversos sintomas multissistêmicos persistentes por semanas ou meses. Entre as sequelas, destacam-se os impactos neurológicos, em especial a depressão e ansiedade. Assim, torna-se necessário investigar os componentes genéticos que contribuem nos transtornos depressivos e ansiosos pós-covid. Para tanto, foi realizada uma curadoria manual com critérios pré-estabelecidos, seguida da coleta de códigos no UNIPROT e construção das redes proteicas pelo Cytoscape. A partir da análise holística dos dados, foram identificados parâmetros topológicos e funcionais relevantes. Como resultado, constatou-se o papel da inflamação sistêmica no sistema nervoso central, a relação bidirecional da inflamação e estresse oxidativo, e a influência das proteínas na inflamação crônica. Sugere-se que os transtornos de humor que são desencadeados pela inflamação, possam interferir na biossíntese de serotonina, neurodegeneração e neurotoxicidade com eventuais alterações cerebrais, em áreas relacionadas ao controle emocional. Dessa forma, este estudo apresentou potenciais biomarcadores que visam auxiliar futuras pesquisas in vivo e in vitro na prospecção de alvos terapêuticos, porém é preciso aprofundar na relação depressão e ansiedade e condições pós- COVID.