bluuebunny/crossref_metadata_2025 huggingface dataset:
Deformations and Homotopy Theory of Relative Rota–Baxter Lie Algebras
Authors: Lazarev Andrey , Sheng Yunhe , Tang Rong
Published: October 2020

We determine the$$L_\infty $$L∞-algebrathat controls deformations of a relative Rota–Baxter Lie algebra and show that it is an extension of the dg Lie algebra controlling deformations of the underlying$$\mathsf {Lie}\mathsf {Rep}$$LieRep pair by the dg Lie algebra controlling deformations of the relative Rota–Baxter operator. Consequently, we define thecohomologyof relative Rota–Baxter Lie algebras and relate it to their infinitesimal deformations. A large class of relative Rota–Baxter Lie algebras is obtained from triangular Lie bialgebras and we construct a map between the corresponding deformation complexes. Next, the notion of ahomotopyrelative Rota–Baxter Lie algebra is introduced. We show that a class of homotopy relative Rota–Baxter Lie algebras is intimately related topre-Lie$$_\infty $$∞-algebras.
Primary stability of calcar-guided short-stem total hip arthroplasty in the treatment of osteonecrosis of the femoral head: migration analysis using EBRA-FCA
Authors: Afghanyar Yama , Danckwardt Christoph , Schwieger Miriam , Felmeden Uwe , Drees Philipp , Dargel Jens , Rehbein Philipp , Kutzner Karl Philipp
Published: October 2020

Introduction

Osteonecrosis of the femoral head (ONFH) is a disabling condition that often results in secondary arthritis necessitating total hip arthroplasty (THA). Short-stem THA has constantly gained popularity. It remains controversial, whether ONFH represents a risk factor for failure after the implantation of short stems with pronounced metaphyseal anchorage. The potential spread of the osteonecrotic area and bone marrow edema into the metaphyseal bone might result in compromised stability. Early implant migration is considered predictive of subsequent aseptic loosening. The purpose of this study was a migration analysis of a modern, calcar-guided short-stem implant in patients with ONFH in a mid-term follow-up.

Materials and methods

This retrospective analysis investigated the migration pattern of 45 calcar-guided short stems in patients with ONFH, using Einzel-Bild-Roentgen-Analyse Femoral-Component-Analysis (EBRA-FCA). Influencing factors such as ARCO categories, age, gender, body weight and BMI were analyzed. Complications and adverse events were documented.

Results

At mid-term [48.1 months (SD 20.7 months)], mean axial migration was 1.56 mm (SD 1.77 mm). Mean migration rate stabilized after 2 years. No influence of ARCO categories, age and BMI was found. A tendency of increased axial migration was observed in male patients and in overweight patients. No revision surgeries had to be performed during follow-up.

Conclusion

The results indicate a migration pattern comparable to that of primary osteoarthritis patients with slight initial migration under full load followed by subsequent stabilization in the metaphyseal femur. The 100% survival rate at mid-term supports the usage of this short-stem design in patients with ONFH.
The effectiveness of health-oriented leadership interventions for the improvement of mental health of employees in the health care sector: a systematic review
Authors: Stuber Felicitas , Seifried-Dübon Tanja , Rieger Monika A. , Gündel Harald , Ruhle Sascha , Zipfel Stephan , Junne Florian
Published: October 2020

Purpose

An increasing prevalence of work-related stress and employees’ mental health impairments in the health care sector calls for preventive actions. A significant factor in the workplace that is thought to influence employees’ mental health is leadership behavior. Hence, effective leadership interventions to foster employees’ (leaders’ and staff members’) mental health might be an important measure to address this pressing issue.

Methods

We conducted a systematic review according to the PRISMA statement (Liberati et al. 2009) and systematically searched the following databases: PubMed (PMC), Web of Science, PsycINFO (EBSCOhost), EconLit (EBSCOhost), and Business Source Premier (EBSCOhost). In addition, we performed a hand search of the reference lists of relevant articles. We included studies investigating leadership interventions in the health care sector that aimed to maintain/foster employees’ mental health.

Results

The systematic search produced 11,221 initial search hits in relevant databases. After the screening process and additional literature search, seven studies were deemed eligible according to the inclusion criteria. All studies showed at least a moderate global validity and four of the included studies showed statistically significant improvements of mental health as a result of the leadership interventions.

Conclusions

Based on the findings, leadership interventions with reflective and interactive parts in group settings at several seminar days seem to be the most promising strategy to address mental health in health care employees. As the available evidence is limited, efforts to design and scientifically evaluate such interventions should be extended.
National oral health survey on refugees in Germany 2016/2017: caries and subsequent complications
Authors: Al-Ani A. , Takriti M. , Schmoeckel J. , Alkilzy M. , Splieth C. H.
Published: October 2020

Objectives

To assess oral health, caries prevalence, and subsequent complications among recently arrived refugees in Germany and to compare these findings with the German resident population.

Methods

This multicenter cross-sectional study recruited 544 refugees aged 3–75+ years; they were examined at ten registration institutions in four federal states in Germany by two calibrated dentists. The refugees were screened for caries (dmft/DMFT) and its complications (pufa/PUFA); this data was compared to the resident population via the representative national oral health surveys).

Results

The deciduous dentition of the 3-year-old refugees had a mean dmft value of 2.62 ± 3.6 compared with 0.48 dmft in the German resident population, and caries increased to 5.22 ± 3.4 for 6–7-year-olds (Germany: 1.73 dmft). Few refugee children had naturally healthy teeth (7% in 6–7-year-olds, Germany: 56%). In the permanent dentition, the gap in caries prevalence between refugees and the German population decreased with age (35–44-year-olds: 10.55 ± 7.1 DMFT; Germany: 11.2), but refugees exhibited more caries defects (35–44-year-olds DT = 3.13 ± 3.0; Germany: 0.5). German residents had more restorations (35–44-year-olds FT = 4.21 ± 4.6). Regarding complications, the 6–7-year-olds exhibited the highest pufa index (0.86 ± 1.4) which decreased in adolescence (13–17-year-olds, 0.18 ± 0.6) and increased in adults (45–64-year-olds, 0.45 ± 0.8).

Conclusion

The refugees had high caries experience, often untreated caries teeth and more complications compared with the German resident population, especially in children. Closing this gap by extending preventive systems to the refugees would decrease future treatment needs.

Clinical relevance

European countries should be prepared for the higher dental treatment needs in recent refugees, especially in children.
Cardiovascular Biomarkers’ Inherent Timescales in Mental Workload Assessment During Simulated Air Traffic Control Tasks
Authors: Radüntz Thea , Mühlhausen Thorsten , Freyer Marion , Fürstenau Norbert , Meffert Beate
Published: October 2020

One central topic in ergonomics and human-factors research is the assessment of mental workload. Heart rate and heart rate variability are common for registering mental workload. However, a major problem of workload assessment is the dissociation among different workload measures. One potential reason could be the disregard of their inherent timescales and the interrelation between participants’ individual differences and timescales. The aim of our study was to determine if different cardiovascular biomarkers exhibit different timescales. We focused on air traffic controller and investigated biomarkers’ ability to distinguish between conditions with different load levels connected to prior work experience and different time slots. During an interactive real-time simulation, we varied the load situations with two independent variables: the traffic volume and the occurrence of a priority-flight request. Dependent variables for registering mental workload were the heart rate and heart rate variability from two time slots. Our results show that all cardiovascular biomarkers were sensitive to workload differences with different inherent timescales. The heart rate responded sooner than the heart rate variability features from the frequency domain and it was most indicative during the time slot immediately after the priority-flight request. The heart rate variability parameters from the frequency domain responded with latency and were most indicative during the subsequent time slot. Furthermore, by consideration of biomarkers’ inherent timescales, we were able to assess a significant effect of work experience on heart rate and mid/high frequency-band ratio of the heart rate variability. Results indicated that different cardiovascular biomarkers reveal different inherent timescales.
Exercise cardiovascular magnetic resonance: feasibility and development of biventricular function and great vessel flow assessment, during continuous exercise accelerated by Compressed SENSE: preliminary results in healthy volunteers
Authors: Craven Thomas P. , Jex Nicholas , Chew Pei G. , Higgins David M. , Bissell Malenka M. , Brown Louise A. E. , Saunderson Christopher E. D. , Das Arka , Chowdhary Amrit , Dall’Armellina Erica , Levelt Eylem , Swoboda Peter P. , Plein Sven , Greenwood John P.
Published: October 2020

Purpose

Exercise cardiovascular magnetic resonance (Ex-CMR) typically requires complex post-processing or transient exercise cessation, decreasing clinical utility. We aimed to demonstrate the feasibility of assessing biventricular volumes and great vessel flow during continuous in-scanner Ex-CMR, using vendor provided Compressed SENSE (C-SENSE) sequences and commercial analysis software (Cvi42).

Methods

12 healthy volunteers (8-male, age: 35 ± 9 years) underwent continuous supine cycle ergometer (Lode-BV) Ex-CMR (1.5T Philips, Ingenia). Free-breathing, respiratory navigated C-SENSE short-axis cines and aortic/pulmonary phase contrast magnetic resonance (PCMR) sequences were validated against clinical sequences at rest and used during low and moderate intensity Ex-CMR. Optimal PCMR C-SENSE acceleration, C-SENSE-3 (CS3) vs C-SENSE-6 (CS6), was further investigated by image quality scoring. Intra-and inter-operator reproducibility of biventricular and flow indices was performed.

Results

All CS3 PCMR image quality scores were superior (p < 0.05) to CS6 sequences, except pulmonary PCMR at moderate exercise. Resting stroke volumes from clinical PCMR sequences correlated stronger with CS3 than CS6 sequences. Resting biventricular volumes from CS3 and clinical sequences correlated very strongly (r > 0.93). During Ex-CMR, biventricular end-diastolic volumes (EDV) remained unchanged, except right-ventricular EDV decreasing at moderate exercise. Biventricular ejection-fractions increased at each stage. Exercise biventricular cine and PCMR stroke volumes correlated very strongly (r ≥ 0.9), demonstrating internal validity. Intra-observer reproducibility was excellent, co-efficient of variance (COV) < 10%. Inter-observer reproducibility was excellent, except for resting right-ventricular, and exercise bi-ventricular end-systolic volumes which were good (COV 10–20%).

Conclusion

Biventricular function, aortic and pulmonary flow assessment during continuous Ex-CMR using CS3 sequences is feasible, reproducible and analysable using commercially available software.
The hemoglobin Gly16β1Asp polymorphism in turbot (Scophthalmus maximus) is differentially distributed across European populations
Authors: Andersen Øivind , Rubiolo Juan Andrés , De Rosa Maria Cristina , Martinez Paulino
Published: October 2020

Turbot is an important flatfish widely distributed along the European coasts, whose fishery is centered in the North Sea. The commercial value of the species has boosted a successful aquaculture sector in Europe and China. Body growth is the main target of turbot breeding programs and is also a key trait related to local adaptation to temperature and salinity. Differences in growth rate and optimal growth temperature in turbot have been shown to be associated with a hemoglobin polymorphism reported more than 50 years ago. Here, we identified a Gly16Asp amino acid substitution in the β1 globin subunit by searching for genetic variation in the five functional globin genes within the whole annotated turbot genome. We predicted increased stability of the turbot hemoglobin by the replacement of the conserved Gly with the negative charged Asp residue that is consistent with the higher rate of αβ dimer assembly in the human J-Baltimore Gly16β->Asp mutant than in normal HbA. The turbot Hbβ1-Gly16 variant dominated in the northern populations examined, particularly in the Baltic Sea, while the Asp allele showed elevated frequencies in southern populations and was the prevalent variant in the Adriatic Sea. Body weight did not associate with the Hbβ1 genotypes at farming conditions (i.e., high oxygen levels, feeding ad libitum) after analyzing 90 fish with high growth dispersal from nine turbot families. Nevertheless, all data at hand suggest that the turbot hemoglobin polymorphism has an adaptive significance in the variable wild conditions regarding temperature and oxygen availability.
Ex situ and in situ conservation gap analysis of crop wild relative diversity in the Fertile Crescent of the Middle East
Authors: Zair Wathek , Maxted Nigel , Brehm Joana Magos , Amri Ahmed
Published: October 2020

Crop wild relatives (CWRs) are important reservoirs of adaptive traits for crop breeding programmes. Both ex situ and in situ conservation approaches should be deployed to ensure CWR availability for use. This paper aims to (a) create a regional database of occurrence records for the 441 priority CWRs in the Fertile Crescent, (b) identify CWR-rich areas in the Fertile Crescent, (c) recommend locations to implement genetic reserves intended for CWRs active in situ conservation and (d) undertake ex situ and in situ conservation gap analyses. The study area comprises Jordan, Syria, Palestine/Israel, Lebanon, Turkey and Iraq. Occurrence records of the 441 priority CWR within the Fertile Crescent were gathered from herbaria, gene banks and online databases. Gaps in the current ex situ and in situ conservation were identified. Hotspots of CWR diversity were identified, and complementary analysis was carried out to identify areas for in situ conservation using DIVA-GIS. Then proposed genetic reserves were compared with the existing protected areas to establish genetic reserve areas whether within or outside the protected areas. A total of 23,878 occurrence records were collated for 441 CWR priorities. The first priority grid square is located in Syria near Tal Kalakh City, close to the Lebanese border from the north. The second priority site is located in Turkey’s Izmir Province near Kemal Atatürk Mahallesi. The third priority site is located in Turkey’s Sahinbey/Gaziantep Province. The ex situ gap analysis revealed that of the 441 taxa, 134 (30%) CWRs are totally absent from the current gene banks collections. Only 307 (70%) CWRs are represented in gene banks, and, of these taxa, 252 (57%) of them have less than 10 accessions in gene banks. A total of 353 taxa were categorised as a high priority for collection and conservation; 23 taxa were categorised as a medium priority and 41 taxa as a low priority. However, 24 taxa were identified that did not require urgent collection (see Supplementary Table 7). The most important areas for a further collection of ex situ conservation are located in the west and south of Turkey across the Mediterranean seashore, north of Lebanon and west of Syria (in Lattakia and Tartus Governorate), across the border between Turkey and Syria and northern Iraq. Ten genetic reserves are recommended in the Fertile Crescent for CWR conservation. The results and methods used will help meet the conservation targets of CWR in the Fertile Crescent; they will also help achieve global food security.
Genetic diversity and differentiation of Olea europaea subsp. cuspidata (Wall. & G.Don) Cif. in the Hajar Mountains of Oman
Authors: Habib Nourin Ahosan , Müller Markus , Gailing Oliver , Patzelt Annette , Al Issai Ghudaina , Krutovsky Konstantin V. , Wiehle Martin
Published: October 2020

Olea europaea subsp. cuspidata (Wall. & G. Don) Cif. is one of the six subspecies important for domestication of olive described as having valuable breeding traits. It is distributed from South Africa to the Middle East and the Mediterranean region to China mainly at mid to high altitudes with adequate precipitation. The currently rather fragmented Olea europaea subsp. cuspidata populations likely represent outposts of a formerly larger and more connected area and are hence vulnerable to additional stresses such as erratic weather extremes and anthropogenic influences. This may result in further fragmentation of stands, shifts in demography, increased clonal growth, lower genetic diversity, and higher differentiation between olive stands. In this study, we present data on Olea europaea subsp. cuspidata growing in the Hajar Mountains, Sultanate of Oman, a large area subjected to many anthropogenic disturbances. We used dendrological traits and genetic parameters to infer its stand and population genetic structure, levels of genetic diversity, and differentiation. To accomplish this, 366 individual trees in total were inventoried and 188 of them genotyped using 12 microsatellite markers. Dendrological measures indicated disturbances mainly due to human activities. Height and crown area of individuals averaged 3.7 m (ranging from 0.2 to 12 m) and 14 m (ranging from 1 to 18 m), respectively. The stand conditional index was mainly 50%. The identified genetic variation within the sampled areas was relatively moderate. The expected and observed heterozygosity equalled 0.55–0.58 and 0.62–0.64, respectively. All individual genotypes were unique indicating the absence of clones. Though significant genetic differentiation was found, there was no evidence of population substructure suggesting effective pollen and long-distance seed dispersal in the past. However, changes in gene flow patterns may be reflected in the next (sibling) generation. Further studies are necessary to detect any changes in the future and to develop sustainable conservation strategies for this species.
The Expression of Success: Are Thin-Slices of Pre-performance Nonverbal Behavior Prior to Throwing Darts Predictive of Performance in Professional Darts?
Authors: Furley Philip , Memmert Daniel
Published: October 2020

The present research attempted to test how skilled people are at predicting perceptual-motor performance of professional darts players based on short observations of pre-performance nonverbal behavior. In four thin-slices experiments (totalN = 490) we randomly sampled stimulus material from the 2017 World Championships of Darts showing short video recordings of the players immediately before throwing darts. Participants were asked to estimate the points scored for the respective throws. Results across four experiments, all of which were successfully replicated in direct replication attempts, supported the hypothesis that pre-performance nonverbal behavior of professional darts players gives valid information to observers about subsequent performance tendencies. The present research is the first to show that highly skilled individuals seem to display nonverbal cues that observers can pick up to draw inferences about how these individuals are likely to perform.
Balancing International Police Cooperation: INTERPOL and the Undesirable Trade-off Between Rights of Individuals and Global Security
Authors: Calcara Giulio
Published: October 2020

With 194 members, INTERPOL is the most influential actor in matters of transnational policing. Regrettably, the organisation is vulnerable against cases of misuse. Certain states manage to exploit the tools of the organisation, to persecute and track political dissidents or non-aligned members of the media outside their borders. As such, INTERPOL has become a prime example on how non-democratic countries can exert their influence and expand their reach well beyond their domestic jurisdictions via their participation in international organisations. Not wanting to allow the proliferation of criminal havens in certain regions, the organisation has opted to connect with and bring together as many police forces of different states as possible. Evidently, such connections are created with little or no consideration of the state of criminal justice systems and forms of government of the countries involved, as well as any subsequent risks. Such a complex state of affairs demands a thorough reflection on whether it is acceptable to compromise between the need for security and the rights of individuals and procedural justice. The issue has vast legal and practical ramifications, and it is ultimately a question pertaining to the realm of global constitutionalism. Does INTERPOL have the legal authority to be in charge of finding a balance between security and procedural justice? If so, on what legal basis, and to what extent?
Leading digital transformation through an Agile Marketing Capability: the case of Spotahome
Authors: Moi Ludovica , Cabiddu Francesca
Published: October 2020

Scholars and practitioners both acknowledge that agility is crucial in leading a digital transformation effort. However, empirical and theoretical research on agile capabilities in an international digital marketing setting is severely lacking. Drawing on qualitative research design methods, this exploratory single-case study involving the international digital firm Spotahome provides an empirical and theoretical investigation of a new marketing capability we define as anAgile Marketing Capability. We identify its key theoretical dimensions and provide empirical guidelines to facilitate its implementation. This study has important implications for international marketing managers, suggesting what strategic actions are needed to deploy agile practices in their marketing strategies and processes from a practical perspective, in the context of an Agile Marketing Capability.
An operational construction of the sum of two non-commuting observables in quantum theory and related constructions
Authors: Drago Nicolò , Mazzucchi Sonia , Moretti Valter
Published: October 2020

The existence of a real linear space structure on the set of observables of a quantum system—i.e., the requirement that the linear combination of two generally non-commuting observables A, B is an observable as well—is a fundamental postulate of the quantum theory yet before introducing any structure of algebra. However, it is by no means clear how to choose the measuring instrument of a general observable of the form $$aA+bB$$

a
A
+
b
B

($$a,b\in {{\mathbb {R}}}$$

a
,
b
∈
R

) if such measuring instruments are given for the addends observables A and B when they are incompatible observables. A mathematical version of this dilemma is how to construct the spectral measure of $$f(aA+bB)$$

f
(
a
A
+
b
B
)

out of the spectral measures of A and B. We present such a construction with a formula which is valid for general unbounded self-adjoint operators A and B, whose spectral measures may not commute, and a wide class of functions $$f: {{\mathbb {R}}}\rightarrow {{\mathbb {C}}}$$

f
:
R
→
C

. In the bounded case, we prove that the Jordan product of A and B (and suitably symmetrized polynomials of A and B) can be constructed with the same procedure out of the spectral measures of A and B. The formula turns out to have an interesting operational interpretation and, in particular cases, a nice interplay with the theory of Feynman path integration and the Feynman–Kac formula.
Healthcare utilization and costs among prolactinoma patients: a cross-sectional study and analysis of determinants
Authors: van der Meulen Merel , Zamanipoor Najafabadi Amir H. , Lobatto Daniel J. , van den Hout Wilbert B. , Andela Cornelie D. , Zandbergen Ingrid M. , Pereira Alberto M. , van Furth Wouter R. , Vliet Vlieland Thea P. M. , Biermasz Nienke R.
Published: October 2020

Purpose

Prolactinomas are the most prevalent functioning pituitary adenomas. They affect gonadal function as well as health-related quality of life (HRQoL). This study aimed to report healthcare utilization and costs, including their determinants, for prolactinoma patients.

Methods

Cross-sectional study of 116 adult prolactinoma patients in chronic care in a Dutch tertiary referral center. Patients completed four validated questionnaires, assessing healthcare utilization and costs over the previous 12 months (Medical Consumption Questionnaire), disease bother and needs (Leiden Bother and Needs Questionnaire Pituitary), HRQoL (Short Form-36), and self-reported health status (EuroQol 5D). Regression analyses were used to assess associations between disease-related characteristics and healthcare utilization and costs.

Results

Mean age was 52.0 years (SD 13.7) and median follow-up was 15.0 years (IQR 7.6–26.1). Patients visited the endocrinologist (86.2%), general practitioner (37.9%), and ophthalmologist (25.0%) most frequently. Psychological care was used by 12.9% of patients and 5% were admitted to hospital. Mean annual healthcare costs were €1928 (SD 3319), mainly for pituitary-specific medication (37.6% of total costs), hospitalization (19.4%) and specialist care (16.1%). Determinants for higher healthcare utilization and costs were greater disease bother and needs for support, lower HRQoL, elevated prolactin, and longer disease duration, while tumor size, hypopituitarism and adrenal insufficiency were not significantly associated with healthcare utilization and costs.

Conclusion

Healthcare utilization and costs of prolactinoma patients are related to patient-reported HRQoL, bother by disease and needs for support. Therefore, addressing patients’ HRQoL and needs is a way forward to improve efficiency of care and patients’ health status.
Glucocorticoid excess and COVID-19 disease
Authors: Guarnotta Valentina , Ferrigno Rosario , Martino Marianna , Barbot Mattia , Isidori Andrea M. , Scaroni Carla , Ferrante Angelo , Arnaldi Giorgio , Pivonello Rosario , Giordano Carla
Published: October 2020

The pandemic of coronavirus disease (COVID-19), a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is causing high and rapid morbidity and mortality. Immune system response plays a crucial role in controlling and resolving the viral infection. Exogenous or endogenous glucocorticoid excess is characterized by increased susceptibility to infections, due to impairment of the innate and adaptive immune system. In addition, diabetes, hypertension, obesity and thromboembolism are conditions overrepresented in patients with hypercortisolism. Thus patients with chronic glucocorticoid (GC) excess may be at high risk of developing COVID-19 infection with a severe clinical course. Care and control of all comorbidities should be one of the primary goals in patients with hypercortisolism requiring immediate and aggressive treatment. The European Society of Endocrinology (ESE), has recently commissioned an urgent clinical guidance document on management of Cushing’s syndrome in a COVID-19 period. In this review, we aim to discuss and expand some clinical points related to GC excess that may have an impact on COVID-19 infection, in terms of both contagion risk and clinical outcome. This document is addressed to all specialists who approach patients with endogenous or exogenous GC excess and COVID-19 infection.
Is the All-Subjected Principle Extensionally Adequate?
Authors: Andrić Vuko
Published: October 2020

This paper critiques the All-Subjected Principle. The All-Subjected Principle is one of the most prominent answers to the Boundary Problem, which consists in determining who should be entitled to participate in which democratic decision. The All-Subjected Principle comes in many versions, but the general idea is that all people who are subjected in a relevant sense with regard to a democratic decision should be entitled to participate in that decision. One respect in which versions of the All-Subjected Principle differ concerns how to best understand ‘subjectedness’. One view spells out ‘subjectedness’ in terms of legal bindingness. Another view understands ‘subjectedness’ in terms of coercion. I argue that the All-Subjected Principle is extensionally inadequate on both views in that it yields verdicts that are at odds with our considered judgements about certain cases. These cases involve legal norms of referral or international administrative assistance.
The experience of Hamad General Hospital collaborative anticoagulation clinic in Qatar during the COVID-19 pandemic
Authors: Abdallah Ibtihal , Eltahir Asma , Fernyhough Liam , El-Bardissy Ahmed , Ahmed Rana , Abdulgelil Mohammed , Elgaily Dina , Mohammed AbdulMoqeeth , Jassim Ameena , Barakat Loluwa , Al-Ansari Mazen , Javed Mehak , Alkhawaja Raja , Elzouki Abdel-nasser
Published: October 2020

Hamad General Hospital Anticoagulation Clinic is one of the largest collaborative-practice clinics of its type in Qatar. The patients being followed at this clinic are typically complex and vulnerable. During the coronavirus disease 2019 pandemic, measures were implemented at the clinic to minimize the exposure of patients and healthcare providers to the acute respiratory syndrome coronavirus-2 and to promote social distancing. These measures included extending INR-recall period, transitioning to direct oral anticoagulant drugs whenever feasible, home visits to elderly and immunocompromised patients for INR testing, establishing an anticoagulation hotline, and relocation of warfarin dispensing from the main pharmacy to the anticoagulation clinic. In addition, the clinic shifted its multidisciplinary team meetings onto an online platform using Microsoft Teams. Telehealth consultations were extensively utilized to closely follow up with the patients and ensure that anticoagulation efficacy and safety remained optimal. The aim of this paper is to share our experience and describe the measures adopted by the clinic as part of the Hamad Medical Corporation response to the emerging situation.
Petrophysical Correlations for the Permeability of Coquinas (Carbonate Rocks)
Authors: Lima M. C. O. , Pontedeiro E. M. , Ramirez M. , Boyd A. , van Genuchten M. Th. , Borghi L. , Couto P. , Raoof A.
Published: October 2020

The pore structure of many carbonate formations is known to be very complex and heterogeneous. Heterogeneity is manifested by the presence of different types, sizes, and shapes of pores resulting from sedimentation and diagenetic actions. These complexities greatly increase uncertainties in estimated rock hydraulic properties in that different permeability values may occur for samples having similar porosities. In order to understand the effects of pore structure and heterogeneity, petrophysical analyses were performed on coquina samples from the Morro do Chaves Formation (Barremian, Sergipe-Alagoas Basin), which is an analogue of Brazilian Pre-salt oil reservoirs of Itapema Formation in the Santos Basin. Routine core analyses, and NMR and MICP measurements were carried out to obtain pore body and pore throat distributions. Obtained T2 relaxation times were converted to pore size radii by matching the NMR and MICP curves. Pore-scale imaging and pore network modelling were performed using microCT scans and the PoreFlow software, respectively. Calculated permeabilities using PoreFlow showed excellent agreement with the routine laboratory measurements. Samples having pore bodies with a higher coordination number showed much larger permeabilities at similar porosities. This study includes a statistical analysis of various features that caused the observed differences in permeability of the coquinas, including the role of connectivity of the entire porous system. Limitations and challenges of the various techniques, and the imaging and pore-scale flow simulations, are discussed.
P2X7 is a cytotoxic receptor….maybe not: implications for cancer
Authors: Di Virgilio Francesco
Published: October 2020

The tumor microenvironment is rich in extracellular ATP. This nucleotide affects both cancer and infiltrating immune cell responses by acting at P2 receptors, chiefly P2X7. ATP is then degraded to generate adenosine, a very powerful immunosuppressant. The purinergic hypothesis put forward by Geoff Burnstock prompted innovative investigation in this field and provided the intellectual framework to interpret a myriad of experimental findings. This is a short appraisal of how Geoff’s inspiration influenced cancer studies and my own investigation highlighting the key role of the P2X7 receptor.
A swing and a child: how scientific phenomena can come to matter for preschool children’s emergent science identities
Authors: Günther-Hanssen Anna
Published: October 2020

The focus of this study is the co-actings of a 5-year-old girl, a swing, and physical phenomena. The study explores how the swing and physical phenomena worked as co-creators of the girl’s scientific explorations as well as her bodily capacities and identity construction. Empirically, the study makes use of a video sequence generated during a field study in a Swedish preschool with 5-year-old children. The field study focused on the children’s play and explorations together with the preschool environment, during activities not specifically guided by teachers. To conceptualize children’s emergent scientific learning as mutual with their identity construction and as being co-created together with nonhuman agents, the study combines perspectives from new materialism, emergent science, physics, and gender theory. As a theoretical and methodological foundation, a new materialist perspective drawing on Karen Barad’s (Meeting the universe halfway. Quantum physics of the entanglement of matter and meaning, Duke University Press, London, 2007) theory of agential realism and diffractive methodology were used, as well as Elizabeth de Freitas and Anna Palmer’s (Cult Stud Sci Educ 11(4):1201–1222, 2016.10.1007/s11422-014-9652-6) notion concerning how scientific concepts can work as creative playmates in children’s explorations. The findings show how the girl, together with the swing, could experience and explore various physical phenomena as well as, extend her bodily capacities and become brave and strong. As such, new materialism shows how scientific phenomena can create affordances for an individual’s becomings as scientific as well as how “becoming scientific” can be understood. At the same time, the findings also indicate the importance of teachers not assuming that scientific phenomena are automatically part of children’s play or can be experienced by all children all the time. The explored situation was rare. On most occasions, the girl did not get the same kind of experiences with the swing because of gender norms. I argue that norms and discourses connected to science and gender are not things that “come with” older children or are only introduced by adults. These are instead already in the making and re-making within children’s co-actings with the material-discursive environment in preschool. It is therefore important that teachers engage in children’s embodied play with scientific phenomena, with the aim to empower the children, their bodies, capacities and (science) identities.
Computational design of heterogeneous catalysts and gas separation materials for advanced chemical processing
Authors: Shi Huaiwei , Zhou Teng
Published: October 2020

Functional materials are widely used in chemical industry in order to reduce the process cost while simultaneously increase the product quality. Considering their significant effects, systematic methods for the optimal selection and design of materials are essential. The conventional synthesis-and-test method for materials development is inefficient and costly. Additionally, the performance of the resulting materials is usually limited by the designer’s expertise. During the past few decades, computational methods have been significantly developed and they now become a very important tool for the optimal design of functional materials for various chemical processes. This article selectively focuses on two important process functional materials, namely heterogeneous catalyst and gas separation agent. Theoretical methods and representative works for computational screening and design of these materials are reviewed.
A computer-aided strategy for preoperative simulation of autologous ear reconstruction procedure
Authors: Mussi Elisa , Servi Michaela , Facchini Flavio , Carfagni Monica , Volpe Yary
Published: October 2020

Autologous ear reconstruction is the preferred treatment in case of partial or total absence of the external ear. The surgery can be very challenging to perform and the aesthetic result highly dependent on the surgeon’s “artistic skills”. In this context a preoperative planning and simulation phase based on the patient’s specific anatomy may result crucial for the surgical outcome. In this work, starting from a case study, the elements necessary for an effective simulation are identified and a strategy for their interactive design and customization is devised with a perspective of a semi-automatization of the procedure.
Menschenrechte: ein kontroverses Diskursfeld
Authors: Scherr Albert
Published: October 2020

Der Beitrag setzt sich kritisch mit der einflussreichen Charakterisierung Sozialer Arbeit als Menschenrechtsprofession auseinander. Aufgezeigt wird insbesondere, dass dies wiederkehrend mit einem unklaren Verständnis der Menschenrechte als Werte und als kodifiziertes Recht einhergeht sowie das Verhältnis von Menschenrechten und sozialstaatlichen Standards vernachlässigt. Deshalb bietet die Idee der Menschenrechtsprofession kein sicheres Fundament für die Klärung der Frage, was in der Sozialen Arbeit getan und unterlassen werden. Problematisiert wird auch die Vorstellung, Soziale Arbeit könne sich selbst ein Mandat erteilen und zudem die Position einer moralisch überlegenen Autorität bei der Interpretation von Menschenrechten beanspruchen.
Update on Cerebellar Ataxia with Neuropathy and Bilateral Vestibular Areflexia Syndrome (CANVAS)
Authors: Dupré Mathieu , Hermann Ruben , Froment Tilikete Caroline
Published: October 2020

The syndrome of cerebellar ataxia with neuropathy and bilateral vestibular areflexia (CANVAS) has emerged progressively during the last 30 years. It was first outlined by the neurootology/neurophysiology community in the vestibular areflexic patients, through the description of patients slowly developing late-onset cerebellar ataxia and bilateral vestibulopathy. The characteristic deficit of visuo-vestibulo-ocular reflex (VVOR) due to the impaired slow stabilizing eye movements was put forward and a specific disease subtending this syndrome was suggested. The association to a peripheral sensory axonal neuropathy was described later on, with neuropathological studies demonstrating that both sensory neuropathy and vestibular areflexia were diffuse ganglionopathy. Clinical and electrophysiological criteria of CANVAS were then proposed in 2016. Besides the classical triad, frequent chronic cough, signs of dysautonomia and neurogenic pains were frequently observed. From the beginning of published cohorts, sporadic as well as familial cases were reported, the last suggestive of an autosomal recessive mode of transmission. The genetic disorder was discovered in 2019, under the form of abnormal biallelic expansion in the replication factor C subunit 1 (RFC1) in a population of late-onset ataxia. This pathological expansion was found in 100% of the familial form and 92% of sporadic ones when the triad was complete. But using the genetic criteria, the phenotype of CANVAS seems to expand, for exemple including patients with isolated neuronopathy. We propose here to review the clinical, electrophysiological, anatomical, genetic aspect of CANVAS in light of the recent discovery of the genetic aetiology, and discuss differential diagnosis, neuropathology and physiopathology.
Modeling and Predicting Trust Dynamics in Human–Robot Teaming: A Bayesian Inference Approach
Authors: Guo Yaohui , Yang X. Jessie
Published: October 2020

Trust in automation, or more recently trust in autonomy, has received extensive research attention in the past three decades. The majority of prior literature adopted a “snapshot” view of trust and typically evaluated trust through questionnaires administered at the end of an experiment. This “snapshot” view, however, does not acknowledge that trust is a dynamic variable that can strengthen or decay over time. To fill the research gap, the present study aims to model trust dynamics when a human interacts with a robotic agent over time. The underlying premise of the study is that by interacting with a robotic agent and observing its performance over time, a rational human agent will update his/her trust in the robotic agent accordingly. Based on this premise, we develop a personalized trust prediction model and learn its parameters using Bayesian inference. Our proposed model adheres to three properties of trust dynamics characterizing human agents’ trust development process de facto and thus guarantees high model explicability and generalizability. We tested the proposed method using an existing dataset involving 39 human participants interacting with four drones in a simulated surveillance mission. The proposed method obtained a root mean square error of 0.072, significantly outperforming existing prediction methods. Moreover, we identified three distinct types of trust dynamics, the Bayesian decision maker, the oscillator, and the disbeliever, respectively. This prediction model can be used for the design of individualized and adaptive technologies.
Religion and Academic Achievement: A Research Review Spanning Secondary School and Higher Education
Authors: Horwitz Ilana M.
Published: October 2020

Profound socio-economic disparities that exist among American religious groups are largely driven by the quantity and quality of education they receive. Furthermore, given the U.S. schooling system is rooted in Protestant ideals, it is possible that students with Protestant commitments have an academic advantage. This article synthesizes literature on how adolescents’ religious commitment and background are associated with their short- and long-term academic outcomes. A literature search identified 42 relevant studies published in 1990-present. These studies were reviewed to identify: (1) the mechanisms through which religion affects educational outcomes—moral, social, and cultural; (2) the main operationalized measures of religion— religious tradition and individual religiosity; and (3) the most frequent academic outcomes studied—secondary school grades, truancy, test scores, educational aspirations, and educational attainment. Of the 42 studies, 95% were based exclusively on quantitative survey data, 95% examined only religiosity or religious tradition, and 66% focused on educational attainment. There were three major findings. First, research has advanced from correlational studies to methodologically rigorous designs suggesting religion can play a causal role in academic success. Second, research reveals a religiosity-religious tradition paradox: Adolescents with stronger religiosity earn better grades, are less truant in secondary school, and complete more years of higher education. A large proportion of highly religious adolescents are likely to be conservative Protestants, but the research on religious tradition suggests that conservative Protestants are among the least educated religious groups. Third, it is unclear if religious adolescents only fare better on academic outcomes that reward their personality, such as grades, or whether they also perform better on more objective measures, such as standardized tests. This systematic review reveals a paradoxical “effect” of academic achievement and religiosity versus-religious tradition. The overall results indicate the need to: (a) identify the interaction between religious tradition and religiosity, (b) distinguish between subjective versus objective academic outcomes; (c) examine heterogeneity among non-religious adolescents; (d) study the interplay between institutional schooling and institutional religion; (e) investigate the religion/cultural match between teachers and students; (f) pursue qualitative research to better understand mechanisms; and (g) expand research about non-Christians.
A Systemic Review on Topical Marketed Formulations, Natural Products, and Oral Supplements to Prevent Androgenic Alopecia: A Review
Authors: Ashique Sumel , Sandhu Navjot Kaur , Haque Sk. Niyamul , Koley Kartick
Published: October 2020

Androgens have an intense consequence on the human scalp and body hair. Scalp hair sprouts fundamentally in awol of androgens whereas the body hair hike is vulnerable to the activity of androgens. Androgenetic alopecia (AGA) invoked as males emulate Alopecia due to the cause of the dynamic reduction of scalp hair. Androgens are medium of terminus growth of hair although the body. Local and system androgens convert the extensive terminal follicles into lesser vellus like structure. The out start of this type of alopecia is intensely irregular and the reason behind this existence of enough circulating steroidal hormones androgens and due to genetic predisposition. Effective treatments are available in the market as well as under clinical and preclinical testing. Many herbal formulations are also available but not FDA approved. Different conventional and NDDS formulations are already available in the market. To avoid various systemic side effects of both Finasteride and Minoxidil, topical formulations and natural products (nutrients, minerals, vitamins) now a days are being widely used to treat Androgenic alopecia. CAM (complementary and alternative medicine) provides the option to elect favorable, low-risk, adjuvant and alternative therapies. Herein, we offer a widespread review of topical marketed formulations, natural products, and CAM treatment options for AGA.

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Recent Endeavors on Molecular Imaging for Mapping Metals in Biology
Authors: Gao Jing , Chen Yuncong , Guo Zijian , He Weijiang
Published: October 2020

Transition metals such as zinc, copper and iron play vital roles in maintaining physiological functions and homeostasis of living systems. Molecular imaging, including two-photon imaging (TPI), bioluminescence imaging (BLI) and photoacoustic imaging (PAI), could act as non-invasive toolkits for capturing dynamic events in living cells, tissues and whole animals. Herein, we review the recent progress in the development of molecular probes for essential transition metals and their biological applications. We emphasize the contributions of metallostasis to health and disease, and discuss the future research directions about how to harness the great potential of metal sensors.

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