bluuebunny/crossref_metadata_2025 huggingface dataset:
Food Waste and Environmental Sustainability of the Hotel Industry in Taiwan
Authors: Lee Hsu-Hua , Huang Pao-Yuan
Published: October 2023

There is an alarming surge in food wastage stemming from culinary practices and intricate cuisines despite technological advancements. The reduction in food wastage is a pivotal sustainable development goal, yet statistics indicate high levels of wastage. Scholars have investigated food waste extensively with a focus on the hospitality sector, which accounts for nearly 12% of total waste. Factors contributing to food waste have been examined, yet findings tend to be isolated and lack a holistic approach. Existing research leans heavily toward developed countries despite the issue being more pronounced in developing economies. Investigations into hotel-related food wastage in Taiwan remain scarce. Effective waste management can curtail expenditures and enhance brand reputation and underscore a commitment to environmental sustainability for hoteliers and culinary managers. This study offers actionable insights to guide sustainable development. The current research employs qualitative interviews and structured questionnaires with culinary experts and hotel management to decode intricacies of food wastage across procurement, inventory, and preparation in Taiwanese hotels. Utilizing the Analytic Network Process methodology, the research provides insights to guide hoteliers in achieving sustainable development goals.
Idiopathic Normal Pressure Hydrocephalus: The Real Social and Economic Burden of a Possibly Enormous Underdiagnosis Problem
Authors: Petrella Gianpaolo , Ciarlo Silvia , Elia Stefania , Piaz Rita Dal , Nucera Paolo , Pompucci Angelo , Palmieri Mauro , Pesce Alessandro
Published: October 2023

Normal Pressure Hydrocephalus (iNPH) typically affects the elderly and can cause cognitive decline, resulting in its differential diagnosis with other neurodegenerative conditions. Moreover, it is probably underdiagnosed; such under- and misdiagnosis prevents the patient from receiving the right treatment and significantly affects the quality of life and life expectancy. This investigation is an in-depth analysis of the actual incidence of iNPH in the population of the province served by our hospital (circa 580,000 individuals). The first phase of this study was conducted by visualizing a total of 1232 brain CT scans performed in the Emergency Departments of the four hospitals of our network on patients who were admitted for different complaints yet screened as suspicious for iNPH. Subsequently, corresponding Emergency Department medical records were investigated to understand the medical history of each patient in search of elements attributable to an alteration of CSF dynamics. The cohort of positive CT scans, according to the radiological and clinical inclusion criteria, included 192 patients. Among the reasons to require acute medical care, “Fall” was the most common. The cumulative incidence of CT scans suggestive of iNPH among the patients undergoing CT scans was as high as 15.58%, and the period prevalence calculated for the total amount of patients accessing the Emergency Departments was 1.084%. The real incidence of iNPH in the population may be underestimated, and the social burden linked to the assistance of patients suffering from such untreated conditions could be significantly relieved.
Closed Timelike Curves Induced by a Buchdahl-Inspired Vacuum Spacetime in R2 Gravity
Authors: Nguyen Hoang Ky , Lobo Francisco S. N.
Published: October 2023

The recently obtained special Buchdahl-inspired metric Phys. Rev. D 107, 104008 (2023) describes asymptotically flat spacetimes in pure Ricci-squared gravity. The metric depends on a new (Buchdahl) parameter k˜ of higher-derivative characteristic, and reduces to the Schwarzschild metric, for k˜=0. For the case k˜∈(−1,0), it was shown that it describes a traversable Morris–Thorne–Buchdahl (MTB) wormhole Eur. Phys. J. C 83, 626 (2023), where the weak energy condition is formally violated. In this paper, we briefly review the special Buchdahl-inspired metric, with focuses on the construction of the Kruskal–Szekeres (KS) diagram and the situation for a wormhole to emerge. Interestingly, the MTB wormhole structure appears to permit the formation of closed timelike curves (CTCs). More specifically, a CTC straddles the throat, comprising of two segments positioned in opposite quadrants of the KS diagram. The closed timelike loop thus passes through the wormhole throat twice, causing two reversals in the time direction experienced by the (timelike) traveller on the CTC. The key to constructing a CTC lies in identifying any given pair of antipodal points (T,X) and (−T,−X) on the wormhole throat in the KS diagram as corresponding to the same spacetime event. It is interesting to note that the Campanelli–Lousto metric in Brans–Dicke gravity is known to support two-way traversable wormholes, and the formation of the CTCs presented herein is equally applicable to the Campanelli–Lousto solution.
Direct Dengue Virus Genome Sequencing from Antigen NS1 Rapid Diagnostic Tests: A Proof-of-Concept with the Standard Q Dengue Duo Assay
Authors: Pérez-Rodríguez Francisco-Javier , Laubscher Florian , Chudzinski Valentin , Kaiser Laurent , Cordey Samuel
Published: October 2023

With nearly half of the world’s population being at risk of infection, dengue virus represents a major global health issue. The use of dengue antigen rapid diagnostic tests (Ag-RDTs) represents an alternative to PCR methods for the diagnosis of acute infections since they display excellent sensitivities and specificities and can be performed outside the laboratory. The high genetic diversity of the dengue virus genome represents a challenge for vaccine development, and the progressive expansion of this virus into previously nonendemic regions justifies the implementation of a genomic surveillance program. In this proof-of-concept study, we show the feasibility of sequencing dengue virus genomes directly from positive Ag-RDT (Standard Q Dengue Duo Test assay, n = 7) cassettes stored up to 31 days at room temperature after testing. For 5 of the 7 samples, a high number of reads were obtained allowing phylogenetic analyses to be carried out to determine not only the serotypes (dengue 1, 2, 3 and 4 were detected) but also the genotypes. Furthermore, in one sample, our unbiased metagenomic next-generation sequencing approach made it possible to detect epizootic hemorrhagic disease virus sequences, an arthropod-transmitted virus in ruminants. To conclude, as such an approach requires no cold storage or freezing of samples, dengue Ag-RDTs represent a very pragmatic and robust alternative for the genomic surveillance of dengue virus.
Covalent Inhibitors from Saudi Medicinal Plants Target RNA-Dependent RNA Polymerase (RdRp) of SARS-CoV-2
Authors: Bakheit Ahmed H. , Saquib Quaiser , Ahmed Sarfaraz , Ansari Sabiha M. , Al-Salem Abdullah M. , Al-Khedhairy Abdulaziz A.
Published: October 2023

COVID-19, a disease caused by SARS-CoV-2, has caused a huge loss of human life, and the number of deaths is still continuing. Despite the lack of repurposed drugs and vaccines, the search for potential small molecules to inhibit SARS-CoV-2 is in demand. Hence, we relied on the drug-like characters of ten phytochemicals (compounds 1–10) that were previously isolated and purified by our research team from Saudi medicinal plants. We computationally evaluated the inhibition of RNA-dependent RNA polymerase (RdRp) by compounds 1–10. Non-covalent (reversible) docking of compounds 1–10 with RdRp led to the formation of a hydrogen bond with template primer nucleotides (A and U) and key amino acid residues (ASP623, LYS545, ARG555, ASN691, SER682, and ARG553) in its active pocket. Covalent (irreversible) docking revealed that compounds 7, 8, and 9 exhibited their irreversible nature of binding with CYS813, a crucial amino acid in the palm domain of RdRP. Molecular dynamic (MD) simulation analysis by RMSD, RMSF, and Rg parameters affirmed that RdRP complexes with compounds 7, 8, and 9 were stable and showed less deviation. Our data provide novel information on compounds 7, 8, and 9 that demonstrated their non-nucleoside and irreversible interaction capabilities to inhibit RdRp and shed new scaffolds as antivirals against SARS-CoV-2.
Virus-like Particle Vaccines of Infectious Bursal Disease Virus Expressed in Escherichia coli Are Highly Immunogenic and Protect against Virulent Strain
Authors: Ji Pengchao , Li Tiantian , Wu Yanan , Zhao Qi , Li Lu , Shi Xuejian , Jiang Wenting , Wang Jiabin , Wang Panpan , Wang Tingting , Jiang Dawei
Published: October 2023

Objectives: Infectious bursal disease virus (IBDV) is a highly contagious, acutely infectious agent that causes immunosuppression in chickens. We expressed IBDV VP2 proteins in Escherichia coli (E. coli) to develop an effective virus-like-particles (VLPs) vaccine and evaluated its immunogenicity. Methods: The VLPs produced in E. coli were used as an immunogen mixed with a water-in-mineral-oil adjuvant (MontanideTM ISA 71 VG, ISA 71 RVG) or a white oil (7#) adjuvant. VLPs without an adjuvant, commercial subunit vaccine, inactivated vaccine, and attenuated vaccine were used as controls. These test vaccines were intramuscularly injected into 19-day-old SPF chickens, which were challenged with the IBDV virulent strain at 30 days after vaccination. Results: The adjuvants boosted antibody production, and the adjuvant groups (except white oil) produced higher antibody levels than the non-adjuvanted controls and the commercial vaccine groups. In terms of cellular immunity, the VLPs plus adjuvant combinations produced higher levels of cytokines, IL-2, IL-4, and IFN-γ than the controls. Conclusion: IBDV VLPs plus the ISA 71 RVG adjuvant can be used as an optimal vaccine combination for improving the immune efficacy of IBD subunit vaccines, which can protect against the virulent strain.
Vaccination and Antiviral Treatment Reduce the Time to Negative SARS-CoV-2 Swab: A Real-Life Study
Authors: De Vito Andrea , Moi Giulia , Saderi Laura , Puci Mariangela V. , Colpani Agnese , Firino Laura , Puggioni Anna , Uzzau Sergio , Babudieri Sergio , Sotgiu Giovanni , Madeddu Giordano
Published: October 2023

Clinical trials demonstrated the role of vaccines and antiviral treatments against SARS-CoV-2 in reducing the likelihood of disease progression and death. However, there are limited data available regarding the time to negativity of people who received these treatments. Further, several comorbidities and risk factors might affect the impact of vaccines and antiviral treatments. To this end, we aimed to evaluate and disentangle the impact of anti-SARS-CoV-2 treatments and that of underlying clinical factors associated with a shortened length of SARS-CoV-2 infection. Hence, we recorded the timeframe of positive nasopharyngeal swab in people infected while being hospitalized for reasons other than SARS-CoV-2 infection. All patients who died or were discharged with a positive swab were excluded from the study. A total of 175 patients were included in this study. Clinical conditions encompass malignancies, immunological disorders, cardiovascular, metabolic, neurodegenerative, and chronic kidney disease. Most of the participants (91.4%) were vaccinated before admission to the hospital, and 65.1% received antiviral treatment within three days after the symptom’s onset. Unvaccinated patients had a longer median time to negativity than people who received at least two doses of vaccine (18 vs. 10 days). Concerning the clinical conditions of all patients, multivariate analysis highlighted a lower probability of 14-day conversion of antigenic test positivity in patients with hematological malignancy, including those vaccinated and those exposed to antiviral therapies. In conclusion, our data showed that prompt administration of antiviral treatments accelerates the clearance of SARS-CoV-2. Further, in the elderly patients under study, previous vaccination and antiviral treatment synergize to reduce time to negativity. This translates into a shorter hospitalization time and a lower risk of transmission through patients and connected healthcare workers in a hospital ward setting, with considerable improvement in cost-effective care management.
Modified Lignocellulosic Waste for the Amelioration of Water Quality: Adsorptive Removal of Congo Red and Nitrate Using Modified Poplar Sawdust
Authors: Velić Natalija , Stjepanović Marija , Pavlović Stefan , Bagherifam Saeed , Banković Predrag , Jović-Jovičić Nataša
Published: October 2023

Since the synthetic dye Congo red and nitrate are notorious contributors to water pollution due to their persistent and potentially toxic nature, it is necessary to develop new efficient methods to remove them from water bodies. Native lignocellulosic materials as biosorbents are mostly inferior, i.e., the adsorption capacities of native materials are lower. Therefore, attempts have been made to improve the adsorption capacities of such materials by physical and/or chemical methods, including the production of biochar. In this study, adsorptive removal was investigated using a novel biosorbent (mPWS) obtained by modifying poplar (waste) sawdust through quaternisation. The characterisation of mPWS included SEM/EDX, FTIR, and MIP analysis. The adsorption of CR and nitrate onto mPWS was studied in a batch system, as a function of contact time (1–240 min), biosorbent concentration (1–8 g·dm−3), and initial adsorbate concentration (25–200 mg·dm−3). In all experiments, a high removal of both adsorbates, from 60 to over 90%, was achieved. Langmuir and Freundlich adsorption isotherm models were used in order to describe equilibrium adsorption data, while pseudo-first-order and pseudo-second-order kinetic models, and the intraparticle diffusion model, were used to describe possible adsorption mechanisms. The Langmuir model fit the adsorption data of CR well, while the nitrate adsorption process was better interpreted with the Freundlich isotherm model. The kinetics data for both CR and nitrate agreed with the pseudo-second-order kinetics model, while analysis using the intraparticle diffusion model indicated two rate-limiting steps during the adsorption process. Based on the results, it can be concluded that the tested novel biosorbent can be effectively used for the removal of CR and nitrate from water (with its adsorption capacities being 70.3 mg·g−1 and 43.6 mg·g−1, respectively).
Hydrochemical Characterization and Quality Assessment of Groundwater in the Southern Plain of Hebei Province, China
Authors: Zhang Longqiang , Dong Donglin , Lv Situ , Zhang Jialun , Yan Maohua , Han Guilei , Li Huizhe
Published: October 2023

The purpose of this research was to understand the hydrogeochemical characteristics and assess the quality of phreatic and confined groundwater in southern Hebei Province. A total of 107 groundwater samples were collected, representing different aquifer conditions over the study area. Multivariate statistical analysis, hydrochemical maps, ionic ratio coefficients, geographic information system (GIS) and geochemical simulation were comprehensively and systematically used to reveal the hydrochemical characteristics of groundwater and its controlling mechanism. The results revealed that both phreatic (pH = 7.02–9.08) and confined groundwater (pH = 7.00–10.60) were slightly alkaline. The hydrochemical types were mainly present as the HCO3-Ca-Mg type in the western premontane area and mixed Ca-Mg-SO4-Cl and Na-Cl-SO4 types in the eastern plains. The hydrochemical composition was dominated by water–rock interactions of natural processes, including silicate weathering, dissolution of sulfate minerals (gypsum, anhydrite), and cation-exchange adsorption. Anthropogenic activities were the main factor causing NO3− content in some groundwater samples to exceed the geochemical baseline. The hydrogeochemistry of groundwater in different aquifers was significantly varied. The average contents of TH, TDS, Na+, Ca2+, Mg2+, Cl− and SO42− in phreatic aquifers were significantly higher than those in confined aquifers. The Entropy Weighted Water Quality Index (EWQI) results revealed that 17.78% of phreatic and 50% of confined water samples were meeting the purpose of drinking water. The groundwater samples with EWQI values exceeding 100 were mainly situated in the Handan urban area and the eastern region of Xingtai City, which should be avoided for direct utilization and needs to be improved through protection and management measures, to enhance the quality of groundwater. Correlation analysis showed that groundwater quality was significantly dominated by TH, TDS, Na+, Mg2+, Cl− and SO42− concentrations.
The Impact of Environmental Factors on the Spatiotemporal Heterogeneity of Phytoplankton Community Structure and Biodiversity in the Qiongzhou Strait
Authors: Xu Chunling , Ma Yu , Zhang Hao , Li Xiaoming , Chen Qi
Published: October 2023

The distribution and variation in environmental factors and the phytoplankton community in the Qiongzhou Strait were investigated in autumn 2015 and spring 2016. The environmental factors were different in the two seasons, as seen when using one-way ANOVA testing, principal component analysis, and cluster analysis. The temperature and levels of dissolved oxygen and soluble solids were higher in autumn, and the ammonia (NH4-N) level was much higher in spring (4.66 ± 0.97 µmol/L), which led to a higher concentration of dissolved inorganic nitrogen in the northeast area. A total of 118 species of phytoplankton were found, with 47 common species in both seasons and more species in spring. Bacillariophyta (diatom) contributed to over 80% of the relative abundance in both seasons. The species of Chrysophyta and Xanthophyta were endemic species in autumn and spring, respectively. Skeletonema costatum and Chaetoceros curvisetus were the common dominant species, with nine dominant species in both seasons. Higher abundance and biodiversity of phytoplankton appeared in spring, and their differences were mostly determined by NH4-N level, hydrodynamic conditions and artificial activities in the coastal area in the Qiongzhou Strait.
Long-Time Water Quality Variations in the Yangtze River from Landsat-8 and Sentinel-2 Images Based on Neural Networks
Authors: Yang Yuanyuan , Jin Shuanggen
Published: October 2023

Total phosphorus (TP) and total nitrogen (TN) represent the primary water quality parameters indicative of the eutrophication status in the mainstream of the Yangtze River. Nowadays, satellite remote sensing offers an economical and efficient method for monitoring the water environment with a broad geographical scope, while single satellite and traditional methods are still limited. In this paper, inversion models of TN and TP are constructed and evaluated based on the neural networks (NNs) algorithm and random forest (RF) algorithm in the upper, middle, and lower reaches of the Yangtze River, respectively. Subsequently, the monthly variations of TN and TP concentrations are estimated and analyzed in the mainstream of the Yangtze River using Landsat-8 and Sentinel-2 satellites images from January 2016 to December 2022. The results show that the NNs model exhibits better estimation performance than the RF model within the study area. The accuracy of the TN model varies across different sections, with R2 values of 0.70 in the upstream, 0.67 in the midstream, and 0.74 in the downstream, accompanied by respective RMSE values of 0.21 mg/L, 0.21 mg/L, and 0.23 mg/L. Similarly, the TP model exhibits varying accuracy in different sections, with R2 values of 0.71 in the upstream, 0.69 in the midstream, and 0.78 in the downstream, along with corresponding RMSE values of 0.008 mg/L, 0.012 mg/L, and 0.008 mg/L. From 2016 to 2022, the concentrations of TN and TP in the mainstream of the Yangtze River exhibited an overall downward trend, with TN decreasing by 13.7% and TP decreasing by 46.2%. Furthermore, this study also gives the possible causes of water quality changes in the mainstream of the Yangtze River with a specific focus on hydrometeorological factors.
ECONOMIC SECURITY OF THE EU AND UKRAINE: NEW CHALLENGES AND THREATS
Authors: Lyzun M. , Ozarko K. ,   West Ukrainian National University,   State University of Intellectual Technologies and Communications
Published: October 2023

The paper examines the issues of economic security of the EU and Ukraine, new challenges and threats that arise as a result of negative processes in the world. The main postulates of the concept of economic security, which is based on counteraction to various threats and has the mandatory condition of protecting the economic interests of the state, are substantiated. It was determined that economic security is an undeniably important component of the country's national security, which includes a set of mechanisms and measures aimed at ensuring the stability of the state's economic system, economic development, and countering internal and external threats. It is noted that the European Union needs a comprehensive strategic approach to economic security, which will make it possible to reduce existing risks, ensure and promote technological advantages in critical sectors. The priorities within which the EU policy in the field of economic security will be implemented are presented: ensuring the competitiveness of EU countries, protection against economic security risks, partnership with the widest possible range of countries. New directions for the implementation of the EU economic security strategy are outlined, which should mitigate risks and eliminate new threats. New risks and threats were identified, as well as destructive processes that had a negative impact on the economic security of Ukraine (destruction of infrastructure and production facilities, halting the implementation of investment projects, inflation, growing negative trade balance, environmental catastrophe, etc.). The need for constant monitoring of risks and threats to economic security in order to form a mechanism and measures aimed at restoring and functioning of Ukraine's economy in the conditions of war is substantiated. The competitive advantages of the Ukrainian economy are determined. The importance of cooperation in the field of economic security of the EU and Ukraine for the successful integration of the Ukrainian and European economies has been proven. Keywords: economic security of the state, national security, risks, geopolitical threats, strategic interests, investment activity, economic development, innovative development, global economy, supply chains, competitiveness, competitive advantages.
CURRENT TRENDS IN THE DEVELOPMENT OF THE WORLD LABOR MARKET
Authors: Lanska S. , Podunai V. ,   Mariupol State University,   Mariupol State University
Published: October 2023

The article is devoted to the definition of modern trends in the development of the world labor market. Restrictions on the functioning of the labor market, which existed in previous periods, as well as modern rules of interaction between employees and organizations are analyzed. It is concluded that most national and global labor markets are showing signs of instability and tension to a greater extent than it was before COVID-19. In addition, post- pandemic transformations caused significant changes in the behavior of employees. Peculiarities of the current state of the countries’ labor markets have been studied. It was studied that the recovery of employment remains at an insufficiently high level. An assessment of the reasons for this development of events is provided. The following were highlighted: the dynamics of labor supply; demographic changes; structure of labor markets; creation and elimination of jobs. It has been established that these determinants differ in different countries. It was concluded that low-income and middle-income countries achieved the worst results. It was highlighted the processes that determinate the impact of globalization on the development of the world labor market. It is emphasized that technologies have led to replacement of labor force, creation of new jobs and fundamentally restructured labor markets. It has been established that transformations in the global labor market are closely related to digitalization processes. The trends regarding changes in the professional and qualification structure of the workforce in modern conditions have been determined. It is concluded that the global labor market has not yet fully recovered from the COVID- 19 crisis and this recovery is very uneven around the world. New global solutions are needed, including with the participation of the ILO, aimed at strengthening and improving policy coherence in order to create conditions for decent work and stabilize the labor market. Key words: labor market, employment, unemployment, workers, employment, instability.
Projektiranje kolekcije odječe, obuće i modnih dodataka inspirirane engleskom gotičkom sakralnom arhitekturom
Authors: Šestan Monica , Šabarić Irena , Doležal Ksenija
Published: October 2023

U ovom se radu istražuje veličanstvenost engleske sakralne gotičke arhitekture, otkrivajući njezino podrijetlo, ključne karakteristike i njen kasniji utjecaj na modni dizajn. Krajnji cilj jest kreirati kolekciju odjeće, obuće i modnih dodataka koja odražava harmonični spoj elemenata engleske sakralne arhitekture i inovativnih modnih formi, dok se inspiracija crpi iz detalja pojedinih arhitektonskih elemenata. S obzirom na bogatstvo unutar opusa povijesti umjetnosti koja se bavi gotičkom arhitekturom, fokus se u ovome radu zadržao na gotičkoj sakralnoj arhitekturi Engleske. Ukupni izgled kolekcije odaje eleganciju i luksuz, s naklonom prošlosti, s ciljem stvaranja odjeće koja obuhvaća bit engleske gotičke sakralne arhitekture, a pritom ostaje nosiva i moderna.
Analisis Faktor – Faktor yang Mempengaruhi Minat Penggunaan Uang Elektronik (LinkAja)
Authors: Dianti Muthia Rahma , Dwi Zulstra Jumadil , Rahim Hamidah
Published: October 2023

Payment systems have been evolving along with technological developments, from the barter system in ancient times to today’s non-cash payment instruments. Electronic money is the newest non-cash payment instrument. The purpose of this paper is to explore the factors that influence postgraduate students’ intention to use LinkAja Application. This research was done in Padang, West Sumatra. A questionnaire was developed from the 160 postgraduate students from three universities in Padang who have LinkAja accounts yet or experience before. The model used here had been developed from the Technology Acceptance Model integrated with the perceived risk theory, five specific risk–performances, financial, security/privacy, social, and time risk was tested on a sample of postgraduate students to explain postgraduate student’s behavioral intention to use LinkAja. A quantitative research method was employed utilizing the survey method. Data were analyzed using the Structural Equation Model technique. The results reveal that perceived usefulness and perceived ease of use consistently have significant and positive impacts on behavioral intention to use LinkAja. However, perceived risk has no significant impact on behavioral intention to use LinkAja. This study confirmed the TAM model is important factor for predicting postgraduate students’ behavioral intention to use LinkAja in Padang Universities.
Naringenin Nedir?
Authors: DEMİRTAŞ Emel
Published: October 2023

Flavonoidler, sebze ve bitkilerin çoğunda yaygın olarak gözlenen geniş bir kapsamı olan bitki besinleri sınıfıdır. Flavonoidler, çeşitli biyolojik aktiviteleri olan önemli doğal bileşiklerdir. Narenciye flavonoidleri önemli bir flavonoid serisini oluşturur. Narenciye flavonoidleri, greyfurt, limon, mandalina, misket limonu, portakal gibi turunçgillerde bulunmaktadır ve terapötik açıdan önemli bir flavanoid sınıfıdır. Narenciye besin bileşenleri, yaygın olarak Vitamin P olarak adlandırılan bir grup biyoaktif flavonoiddir ve naringenin, naringin, quercetin, diosmetin, narirutin, diosmin, nobiletin, neohesperidin, rutin, hesperidin, tangeritin vb. içerir. Naringenin (5,7,4'-trihidroksiflavanon) flavanonlar adı verilen flavonoidler sınıfına aittir. Naringenin, osteoporoz, kanser ve kardiyovasküler hastalıklarda faydalı etkilerle ilişkilidir. Naringenin'in başlıca etkileri arasında ksantin oksidaz, nikotinamid adenin dinükleotid fosfat oksidaz, lipoksijenaz ve siklooksijenaz gibi pro-oksidan enzimlerin inhibisyonu; metal iyon şelasyonu ve en önemlisi serbest radikallerin temizlenmesi yer alır.
The Dialogue Between Faith and Reason According to John Paul II and Thomas Aquinas
Authors: Setiawan Charles Virgenius
Published: October 2023

Some individuals opt for unquestioning their faith, while others lean more toward reason and distance themselves from faith. The former extreme can lead to anarchic and uncontrolled religious militancy within society, whereas the latter extreme can result in the waning of faith. This study aims to address the placement of the dialogue between faith and reason. The qualitative method, utilizing in-depth literature, is employed for this investigation. The Encyclical Letter Fides et Ratio and the writings of Thomas Aquinas were selected as key sources to delve into this topic. The results of this study indicate that discourses about the interaction between faith and reason do not always coexist, there are times when reason is sidelined and there are times when reason is upheld as the main truth. Being a good Christian requires constant effort to have a dialogue between faith and reason. Through this process, faith is enriched by reason, while reason is enlightened by the illuminating light of faith.
Pengharapan dalam Terang Ajaran Iman Katolik
Authors: Situmorang Markus
Published: October 2023

In the Catholic faith, hope is specifically defined as theological virtue. Hope is not just a psychological impulse or temporary emotion but the fruit of faith in Jesus. The finality of hope does not stop at earthly things. However, this does not mean that we should not hope for good things while in this world. The purpose of this study is to answer the difficulties of Christians in understanding and living the meaning of hope in the midst of a world full of challenges. The method used in this research is a qualitative method using literature study. Scripture texts, Church documents and the thoughts of theologians that discuss hope will be studied using descriptive analysis. The results of this study show that in facing of bitter and dark experiences in life, the followers of Christ must remain steadfast in hope. The correct understanding of hope makes believers strong in facing challenges and problems. A follower of Christ needs to direct every hope to heaven as the finality of life on earth.
Ensiklik Fratelli Tutti Sebagai Kunci Pemikiran Dari Evangelii Gaudium Mengenai Paroki Sebagai Pusat Misi
Authors: Wuriningsih Fransisca Romana , Setiyaningtiyas Nerita
Published: October 2023

Paus Fransiskus menetapkan bahwa bulan Oktober 2019 menjadi Bulan Misi Luarbiasa. Salah satu bentuk kegiatan tersebut adalah memberi perhatian kepada paroki. Sampai saat ini, paroki adalah bentuk kehidupan Katolik dalam wilayah tertentu dengan seorang atau beberapa imam yang masih tetap sebagai rujukan utama bagi hidup orang-orang Katolik. Karena itu perlu ada sebuah klarifikasi mengenai model “paroki” yang seperti apa yang diamanatkan oleh Paus Fransiskus agar rumusan mengenai “paroki sebagai pusat misi” ditemukan. Metode yang digunakan dalam penelitian ini adalah metode penelitian kualitatif berupa penelusuran, observasi, dan dokumentasi atas teks-teks Magisterium dan artikel yang relevan dengan fokus penelitian. Temuan penelitian menunjukkan bahwa terdapat empat tema yang perlu dibahas untuk menunjukkan keberadaan paroki sebagai pusat misi, yaitu: 1) identitas paroki, 2) parish ministry, 3) pastoral planning, dan 4) kelompok kategorial di tengah aktivitas misioner paroki. Kesimpulan yang didapatkan dari pembahasan adalah bahwa sifat perutusan paroki bersumber dari keberadaan Jemaat paroki sebagai Tubuh Mistik Kristus, Sang Misionaris.
The Impact of Volunteerism on Community Resilience in Disaster Management
Authors: Ganoe Marti , Roslida Joyner , Sihotang Togarman
Published: October 2023

This research investigates the indispensable role of volunteers in disaster management and their profound impact on communities grappling with the aftermath of natural disasters. The study comprehensively explores the motivations that propel volunteers into action, their effectiveness in disaster response, and the far-reaching consequences of their involvement. The primary motivation of volunteers is revealed to be altruism, accompanied by a strong sense of duty and personal experience with disasters. Their effectiveness in disaster management is evident in their rapid response times and versatile contributions, complementing formal emergency services. Importantly, the impact of volunteers extends beyond immediate relief efforts, fostering heightened community resilience, accelerated economic recovery, improved psychological well-being among survivors, and community empowerment. The research also highlights the need for nuanced investigations into the psychological well-being of volunteers, the influence of cultural contexts on volunteer motivations, and ethical considerations within the framework of disaster volunteering. This study underscores the transformative potential of volunteers in disaster management and calls for policies and practices that recognize, empower, and support these altruistic individuals. By fostering a culture of volunteerism and enhancing disaster preparedness, response, and recovery efforts, communities can become more resilient and better equipped to navigate the challenges posed by natural disasters.
Microwave Energy Harvesting With No Extra Receiving Antenna
Authors: YAŞLI Ahmet , ÜLKER Sadık
Published: October 2023

This paper addresses different cases of radio frequency harvesting using different antenna types as

transmitting antenna but using just the lead of the capacitor as the wire antenna at the receiving end

with a voltage rectifier circuit. Different antennas were used in the input and with two different

rectification circuits the conversion efficiencies were studied accordingly. For a source of log periodic

antenna, without any antenna, 27.31% RF-DC power conversion efficiency value was obtained at the

far-field. For a source of half wavelength dipole antenna, at the near-field, 50.53% RF-DC power

conversion efficiency value was obtained. For a source of helical antenna, up to 5 cm distance about

14.78% RF-DC power conversion efficiency was observed. For the Yagi-Uda antenna used as a source,

RF-DC power conversion efficiency that was obtained at the far was 28.89% without any receiving

antenna..
Jenerik Katı Bir Füze Kanat Geometrisinin Doğal Frekans Değerlerinin Çok Amaçlı Geometrik Optimizasyonu
Authors: TOLA Ceyhun , AKSEN Ukte
Published: October 2023

Havadan karaya füze sistemlerini uzak mesafeden hedefe göndermek, taarruz eden hava platformunun

düşman unsurlarına mümkün olduğunca daha uzak kalmasını sağlamak açısından kritik öneme sahiptir.

Bu bağlamda, hâlihazırda kullanımda olan kanatsız mühimmatlar için kanat kitlerinin geliştirilmesi önem

kazanmıştır. Geliştirilen kanat kitleri, aerodinamik performans bakımından tatmin edici sonuçlar

sunmalı, uçuş sırasında karşılaşılabilecek en kritik yüklere dayanmalı ve kanadın en düşük doğal frekans

değeri kuyruk kontrolcüsünün manevra ve denge sağlama amacıyla uyguladığı müdahale frekansından

daha yüksek olmalıdır. Çalışma kapsamında, içi dolu metalik bir jenerik füze kanadının çok amaçlı

geometrik optimizasyonu parçacık sürü optimizasyonu yöntemi kullanılarak gerçekleştirilmiştir. Sonlu

elemanlar analizleri, Abaqus yazılımında parametrik model oluşturmak ve çözüm gerçekleştirmek

amacıyla hazırlanan Python kodu yardımıyla gerçekleştirilmiş; optimizasyon akışı ve çözümleri ise

ModeFrontier yazılımında yürütülmüştür. Kanat açıklığı boyunca kanadın kök, ara ve uç kesitinde

kullanılan kanat profilleri, kanat profil değişiminin gerçekleştiği ara kesitin köke olan mesafesi, uç ve ara

kesitteki veter uzunlukları, kökten ara kesite ve ara kesitten kanat ucuna olan ok açıları optimizasyon

değişkenleri olarak belirlenmiştir. Optimizasyon kapsamında, kanat alanının ve doğal titreşim analizleri

sonucunda elde edilen birinci moda ait doğal frekans değerinin maksimize edilmesi, kanat kütlesinin ise

minimize edilmesi hedeflenmiştir. Kanadın yeterli taşıma kuvvetini oluşturabilmesi için gerekli

minimum kanat alanı kısıt olarak tanımlanmıştır. Ayrıca kökten uca doğru kanat profillerinin sabit

kalması ya da doğrusal olarak incelmesi ve sivrilmesini sağlayacak kısıtlar tanımlanmıştır. Optimizasyon

sonucunda 1897 adet uygulanabilir, 1107 adet kısıtları ihlal eden ve dolayısıyla uygulanamayan çözüm

elde edilmiştir. Son olarak, girdi parametrelerinin kanadın birinci titreşim modunun doğal frekans değeri

üzerindeki etkileri hassasiyet analizi sonucunda belirlenmiştir.
Grafen Oksit/Altın/Polianilin Nanokompozitlerinin Eş Zamanlı Çöktürme/Polimerizasyon Yöntemleriyle Sentezi ve Fototermal Performansı
Authors: SOYSAL Furkan , ÇIPLAK Zafer
Published: October 2023

Bu çalışmada, grafen oksit (GO) üzerinde tek basamakta altın tuzunun (HAuCl4) indirgenmesi ve anilin

monomerinin polimerize edilmesiyle GO/Au/Polianilin (PANI) nanokompozitleri faklı bileşimlerde

sentezlenmiş, karakterize edilmiş ve 808 nm dalgaboyuna sahip bir lazer ile fototermal özellikleri

incelenmiştir. 1.5 W/cm2 lazer güç yoğunluğunda 0.1 mg/mL derişime sahip nanokompozit

dispersiyonları arasında 10 dakikalık ısıtma işlemi sonucunda ulaşılan en yüksek sıcaklık GO1-Au-PANI4

nanokompozitinde 62.6 °C, en yüksek fototermal dönüşüm verimi ise 0.384 olmuştur. Bu nanokompozit

üzerinde tekrarlı ısıtma soğutma deneyleri gerçekleştirilmiş ve ulaşılan en yüksek sıcaklıkta kayda değer

bir değişiklik gözlenmemiştir. GO/Au/PANI nanokompozitinin tek basamaklı kolay sentez yöntemi ve

yüksek fototermal performansı ile umut verici bir fotoajan olduğu tespit edilmiştir.
Chaotic Snake Optimizer
Authors: YILDIZDAN Gülnur
Published: October 2023

Metaheuristic algorithms provide approximate or optimal solutions for optimization problems in a

reasonable time. With this feature, metaheuristic algorithms have become an impressive research area

for solving difficult optimization problems. Snake Optimizer is a population-based metaheuristic

algorithm inspired by the mating behavior of snakes. In this study, different chaotic maps were

integrated into the parameters of the algorithm instead of random number sequences to improve the

performance of Snake Optimizer, and Snake Optimizer variants using four different chaotic mappings

were proposed. The performances of these proposed variants for eight different chaotic maps were

examined on classical and CEC2019 test functions. The results revealed that the proposed algorithms

contribute to the improvement of Snake Optimizer performance. In the comparison with the literature,

the proposed Chaotic Snake Optimizer algorithm found the best mean values in many functions and

took second place among the algorithms. As a result of the tests, Chaotic Snake Optimizer has been

shown to be a promising, successful, and preferable algorithm.
Molten Salt Approach for Co3O4 Synthesis as a Charge Storage Electrode
Authors: KURTAN Ümran
Published: October 2023

A versatile molten salt method was targeted to fabricate the cobalt oxide (Co3O4) nanospheres as

charge storage electrodes. The Co3O4 nanospheres were prepared in KNO3 molten salt in only one step

within 5 minutes. The nanospheres were with an average size distribution of almost 80-130 nm. The

specific capacitance of cobalt oxide was found to be 285 F/g at 10 mV/s and 171 F/g at 0.5 A /g in 6 M

KOH and the Trasatti method was used to understand the outer and inner surface capacitive

contributions. The material possessed a moderate rate capability (63.1% at 5 A/g) and had good cyclic

stability (90.5% after 1200 cycles). This experimental study does not require any solvent usage and thus

can provide a green and continuous approach for the preparation of various transition metal oxides

with good electrochemical properties in the energy storage field.
Mask R-CNN ile Mikroskobik İdrar Görüntüsü İçeriklerinin Tespiti
Authors: YÖRÜK Yunus Emre , SARAOĞLU Hamdi Melih , ÖZER Ömer Faruk
Published: October 2023

Mikroskobik idrar içerikleri doğru ve dikkatli bir şekilde analiz edildiğinde vücut hakkında önemli bilgiler

verir. İdrar tahlilinin insan sağlığı için önemi nedeniyle mikroskobik idrar içeriklerinin tespit edilmesi

amacıyla derin öğrenme görüntü işleme tekniği kullanılarak yapay zeka uygulamaları yapılmıştır.

Literatürde yer alan çalışmaların çoğunda genel olarak semantik segmentasyon üzerine yoğunlaşılmıştır.

Bu çalışmada ise piksel düzeyinde segmentasyon yapabilen Mask R-CNN modeli ile mikroskobik idrar

görüntülerindeki alyuvar, akyuvar, epitel, kristal, bakteri ve mantar içerikleri konum ve nesne türü

bilgisiyle birlikte tespit edilmiştir. Mask R-CNN ile tespit edilen nesnelere maske ve çerçeve olmak üzere

iki tip sınır çizilmektedir. Sistemin performansı her iki sınır tipi için ayrı ayrı incelenmiştir. Test için

kullanılan 100 görüntüdeki toplam 1154 örüntüden maskelere göre 808 ve çerçevelere göre 843 nesne

doğru şekilde tespit edilmiştir (IoU=0,5). En iyi tespit oranı akyuvarlar ve alyuvarlar için gerçekleşmiştir.

Epiteller çerçevelere göre hesaplamada başarılı bir şekilde tespit edilmiştir fakat düzgün maske

oluşturulamamıştır. Bakteriler diğerlerine göre çok küçük olduğu için doğru tespit oranı düşük kalmıştır.

Kristallerin ve mantarların çoğu doğru şekilde tespit edilmiştir. Ayrıca, nesne tespitinde sıklıkla kullanılan

değerlendirme metriği mAP de hesaplanmıştır. Sistem için hesaplanan mAP değerleri maskelere göre

0,7842 ve çerçevelere göre 0,8343 olmuştur. Mask R-CNN sistemi iyi bir şekilde optimize edilip daha

fazla idrar içeriğine ait görüntülerle eğitilmesi durumunda idrar analiz sistemlerinde kullanılabilir.
El neumotórax espontáneo tuberculoso
Authors:   , Grave Eduardo
Published: October 2023

El neumotórax espontáneo tuberculoso: historia, tipos etiológicos, evolución, diagnóstico, pronóstico, diagnóstico, tratamiento.
Enfermedad celíaca
Authors:   , Forziano José Alberto
Published: October 2023

Emplearemos el término enfermedad celíaca aplicado a "aquellos pacientes que tienen diarreas crónicas y recurrentes, algunas veces entre los 6 meses y los 6 años, sin demostrable base anatómica y bacteriológica, que tienen intolerancia a una dieta normal para su edad; responden a un tratamiento dietético, al mismo tiempo en su curso tienen un abdomen abombado y una curva baja de su peso.- Esta es la definición semilógica dada por Doroty Andersen, ante la imposibilidad de dar una definición etiológica, cumpliendo las exigencias del apotema de Koch: o una base anátomo patológica como en las nefropatías. El haber observado durante varios años la evolución clínica de una enfermita que nos ha tocado atender nos ha animado a la presentación de este caso, enfermedad celíaca, al mismo tiempo que nos servirá para señalar algunas de las últimas adquisiciones de esta enfermedad. Como ya dijéramos ante la ausencia de lesión anatómica característica, de anomalías en la flora intestinal o de insuficiencias comprobables de los procesos enzimáticos digestivos que expliquen la incorrecta absorción intestinal plantea un problema respecto a etiopatogenia de la enfermedad celíaca que durante mucho tiempo no tuvo respuesta satisfactoria. Pasemos revistas a las distintas teorías que han tratado y tratan de resolver el problema etiopatogénico de esta enfermedad.
Risk Analysis and Tsunami Disaster Mapping in Mamuju, West Sulawesi Using TUNAMI-N2
Authors: Bandangan Theresya Maharani , Pasau Guntur , Tamuntuan Gerald Hendrik
Published: October 2023

Kota Mamuju merupakan kawasan pulau Sulawesi yang memiliki keindahan alam yang luar biasa hal ini menyebabkan kota Mamuju sering dijadikan salah satu tempat untuk berwisata khususnya wisata bahari sehingga berpotensi terdampak oleh bencana karena berada dipesisir selat makassar yang merupakan lokasi pusat gempa bumi besar pemicu tsunami. Penelitian ini bertujuan untuk menentukan run-up maksimum gelombang tsunami dan waktu tiba gelombang tsunami yang dapat menerjang Kota Mamuju, Sulawesi Barat serta menganalisis resiko yang terjadi akibat gelombang tsunami tersebut. Metode yang digunakan dalam penelitian ini adalah pemodelan menggunakan perangkat lunak TUNAMI-N2. Hasil dari penelitian ini menunjukkan bahwa tsunami dengan kekuatan gempa 7,3 Mw memiliki ketinggian gelombang maksimum 804 cm ataun 8,04 m pada menit ke-18 dengan resiko yang sangat tinggi.
Calcium channel blockers for hypertension: old, but still useful
Authors: Lee Eun Mi
Published: October 2023

Calcium channel blockers (CCBs) constitute a heterogeneous class of drugs that can be divided into dihydropyridines (DHPs) and non-DHPs. DHP-CCBs are subcategorized into four generations based on the duration of activity and pharmacokinetics, while non-DHP-CCBs are subcategorized into phenylethylamine and benzodiazepine derivatives. DHP-CCBs are vascular-selective and function as potent vasodilators, whereas non-DHP-CCBs are cardiac-selective and are useful for treating tachyarrhythmia, but reduce cardiac contractility and heart rate. Traditional DHP-CCBs (nifedipine) mainly block L-type calcium channels, whereas novel CCBs block N-type (amlodipine) and/or T-type channels (efonidipine) in addition to L-type channels, leading to organ-protective effects. DHP-CCBs have a potent blood pressure–lowering effect and suppress atherosclerosis and coronary vasospasm. Diltiazem, a non-DHP-CCB, is highly effective for vasospasm control. CCBs reduce left ventricular hypertrophy and arterial stiffness. Amlodipine, a DHP-CCB, reduces blood pressure variability. L/N- and L/T-type CCBs combined with renin-angiotensin system blockers reduce proteinuria and improve kidney function compared with L-type CCBs. According to large-scale trials, DHP-CCBs reduce cardiovascular events in patients with isolated systolic hypertension, as well as in elderly and high-risk patients. Accordingly, CCBs are indicated for hypertension in elderly patients, isolated systolic hypertension, angina pectoris, and coronary vasospasm. Non-DHP-CCBs are contraindicated in high-grade heart block, bradycardia (<60 beats per minute [bpm]), and heart failure with reduced ejection fraction (HFrEF). DHP-CCBs should be used with caution in patients with tachyarrhythmia, HFrEF, and severe leg edema, and non-DHP-CCBs should be used carefully in those with constipation. Each CCB has distinct pharmacokinetics and side effects, underscoring the need for meticulous consideration in clinical practice.
HIV Risk-Taking Behaviours as Consequences of HIV Knowledge and Perceived Risk of HIV among University Undergraduates
Authors: Olapegba Peter O. , Ladeinde Victor Seun
Published: October 2023

This study examined knowledge and perceived risk of HIV infection as factors likely to affect HIV risk-taking behaviours. Two hundred and sixty nine undergraduates of the University of Ibadan participated in this cross-sectional survey (154 male and 115 female). Data were collected using three structured and validated scales. Results indicated that HIV knowledge has a significant effect on HIV ,risk-taking behaviours. Perceived risk of HIV also has a significant effect on risk-taking behaviours. It was concluded that inadequate/inappropriate knowledge of HIV, increases HIV risk-taking behaviours. Attitudes that personal efforts do not affect health outcomes also increases HIV risk-taking behaviours. It is thus recommended that HIV awareness campaigns be intensified, while attitudinal change initiatives I should be embarked upon to discourage HIV risk-taking behaviour.