bluuebunny/crossref_metadata_2025 huggingface dataset:
One‐Pot Synthesis of Cu2O/Cu Self‐Assembled Hollow Nanospheres with Enhanced Photocatalytic Performance
Authors: Zhou Bo , Liu Zhiguo , Zhang Haijun , Wu Yan
Published: March 2014

Cu2O/Cu hollow spheres are prepared using one‐pot template‐free solvent‐thermal synthesis route with (CH3COO)2Cu·H2O as a precursor. With the reaction time increasing gradually from 2 h to 20 h, the morphology of the Cu2O/Cu evolves from nanoparticle to hollow nanosphere. The hollow structure is obtained when the cooling rate falls down to 0.7°C/min. And the content of Cu in the hollow spheres also can be easily controlled by adjusting the solvent‐thermal synthesis time. Using photocatalytic degradation of phenol as the probe molecules under visible‐light illumination, we have investigated the influence of hollow structure on the photocatalytic activity of Cu2O/Cu. The prepared hollow sphere Cu2O/Cu particles exhibited a higher photodegradation capability than nanoparticles and solid spheres. When the content of Cu lies in the range of 11–86 wt%, the samples exhibit higher photocatalytic performance, indicating that the Cu2O/Cu particles with hollow structure are promising candidates for the processing of pollutants.
Applying UPC Scaling-Up Methodology to the LSTF-PKL Counterpart Test
Authors: Martinez-Quiroga V. , Reventos F. , Freixa J.
Published: March 2014

In the framework of the nodalization qualification process and quality guarantee procedures and following the guidelines of Kv-scaled analysis and UMAE methodology, further development has been performed by UPC team resulting in a scaling-up methodology. Such methodology has been applied in this paper for analyzing discrepancies that appear between the simulations of two counterpart tests. It allows the analysis of scaling-down criterion used for the design of an ITF and also the investigation of the differences of configuration between an ITF and a particular NPP. For analyzing both, it applies two concepts “scaled-up nodalizations” and “hybrid nodalizations.” The result of this activity is the explanation of appeared distortions and its final goal is to qualify nodalizations for their use in the analysis of equivalent scenarios at an NPP scale. In this sense, the experimental data obtained in the OECD/NEA PKL-2 and ROSA-2 projects as counterpart test are of a great value for the testing of the present methodology. The results of the posttest calculations of LSTF-PKL counterpart tests have allowed the analyst to define which phenomena could be well reproduced by their nodalizations and which not, in this way establishing the basis for a future extrapolation to an NPP scaled calculation. The application of the UPC scaling up methodology has demonstrated that selected phenomena can be scaled-up and explained between counterpart simulations by carefully considering the differences in scale and design.
Social and Ecological Drivers of the Economic Value of Pollination Services Delivered to Coffee in Central Uganda
Authors: Théodore Munyuli Bin Mushambanyi
Published: March 2014

On-farm pollination experiments were conducted in 30 different small-scale coffee fields to determine monetary value attributable to pollination services in coffee production and to identify the degree of influences of various socio-ecological drivers in Uganda. Ecological-economic approaches were applied to determine the economic value of pollinating services. Economic value of bees increased significantly with increase in coffee farm size, bee diversity, and cover of seminatural habitats. The value of bees declined sharply (P<0.05) with forest distance and cultivation intensity. Economic values of pollinating services associated with coffee fields established in regions with low intensity were found to be high. Organically managed small-scale coffee fields were 2 times more profitable than commercially managed farms. The annual value of pollinating services delivered by wild bees oscillated between US$67.18 and US$1431.36. Central Uganda produces in total 0.401 million tons of coffee beans for an approximate economic value of US$214 million from which US$149.42 million are attributable to pollination services. Policy makers should strengthen environmental/agricultural extension service systems to better serve farmers. Farmers are recommended to protect/increase the cover of natural and semi-natural habitats in the vicinity of their coffee fields to receive high economic benefits from pollinating services delivered by bees.
On the Role of Climate Forcing by Volcanic Sulphate and Volcanic Ash
Authors: Langmann Baerbel
Published: March 2014

There is overall agreement that volcanic sulphate aerosols in the stratosphere can reduce solar radiation reaching the earth’s surface for years, thereby reducing surface temperatures, affecting global circulation patterns and generally the global climate system. However, the response of the climate system after large volcanic eruptions is not fully understood and global climate models have difficulties to reproduce the observed variability of the earth system after large volcanic eruptions until now. For geological timescales, it has been suggested that, in addition to the stratospheric climate forcing by volcanic sulphate aerosols, volcanic ash affects climate by modifying the global carbon cycle through iron fertilising the surface ocean and stimulating phytoplankton growth. This process has recently also been observed after the eruption of the volcano Kasatochi on the Aleutian Islands in summer 2008. To trigger future research on the effect of volcanic ash on the climate system via ocean iron fertilisation, this review paper describes the formation processes and atmospheric life cycles of volcanic sulphate and volcanic ash, contrasts their impact on climate, and emphasises current limitations in our understanding.
Effective Design of Profiling Float Network for Oceanic Heat-Content Monitoring
Authors: Masuda Shuhei , Hosoda Shigeki
Published: March 2014

Schemes for optimizing ocean observation programs are presently the subject of increased interest since in principle they should lead to the improved understanding of the dynamical state of the ocean that is required within the present regime of climate change. Here we use an adjoint sensitivity analysis together with a four-dimensional fluctuating oceanic current system to identify key regions for intensive monitoring by drifting profiling float. In this way we aim to maximize observational efficiency. As a scientific benchmark for the validity of our approach, we have attempted to define the ambient sensitivity of the oceanic heat content to a subtle change in water temperature within the Pacific Basin. We focus on the interannual to multidecadal variations in particular. As a result, sensitivity signals reflecting changes in heat content exhibit a characteristic pattern in the three-dimensional continuum and have drastic temporal changes. This implies that the key regions will depend greatly on the operational timeframe of the observing system. We demonstrate a more effective geographic deployment strategy for the profiling floats monitoring changes in the oceanic heat content on a decadal timescale.
Antioxidant Activity of Extract and Its Major Constituents from Okra Seed on Rat Hepatocytes Injured by Carbon Tetrachloride
Authors: Hu Lianmei , Yu Wenlan , Li Ying , Prasad Nagendra , Tang Zhaoxin
Published: March 2014

The antioxidant activities and protective effects of total phenolic extracts (TPE) and their major components from okra seeds on oxidative stress induced by carbon tetrachloride (CCl4) in rat hepatocyte cell line were investigated. The major phenolic compounds were identified as quercetin 3-O-glucosyl (1→6) glucoside (QDG) and quercetin 3-O-glucoside (QG). TPE, QG, and QDG from okra seeds exhibited excellent reducing power and free radical scavenging capabilities includingα,α-diphenyl-β-picrylhydrazyl (DPPH), superoxide anions, and hydroxyl radical. Overall, DPPH radical scavenging activity and reducing power of QG and QDG were higher than those of TPE while superoxide and hydroxyl radical scavenging activities of QG and TPE were higher than those of QDG. Furthermore, TPE, QG, and QDG pretreatments significantly alleviated the cytotoxicity of CCl4on rat hepatocytes, with attenuated lipid peroxidation, increased SOD and CAT activities, and decreased GPT and GOT activities. The protective effects of TPE and QG on rat hepatocytes were stronger than those of QDG. However, the cytotoxicity of CCl4on rat hepatocytes was not affected by TPE, QG, and QDG posttreatments. It was suggested that the protective effects of TPE, QG, and QDG on rat hepatocyte against oxidative stress were related to the direct antioxidant capabilities and the induced antioxidant enzymes activities.
Wavelet Method for Numerical Solution of Parabolic Equations
Authors: Choudhury A. H.
Published: March 2014

We derive a highly accurate numerical method for the solution of parabolic partial differential equations in one space dimension using semidiscrete approximations. The space direction is discretized by wavelet-Galerkin method using some special types of basis functions obtained by integrating Daubechies functions which are compactly supported and differentiable. The time variable is discretized by using various classical finite difference schemes. Theoretical and numerical results are obtained for problems of diffusion, diffusion-reaction, convection-diffusion, and convection-diffusion-reaction with Dirichlet, mixed, and Neumann boundary conditions. The computed solutions are highly favourable as compared to the exact solutions.
Cooperative Quantum-Behaved Particle Swarm Optimization with Dynamic Varying Search Areas and Lévy Flight Disturbance
Authors: Li Desheng
Published: March 2014

This paper proposes a novel variant of cooperative quantum-behaved particle swarm optimization (CQPSO) algorithm with two mechanisms to reduce the search space and avoid the stagnation, called CQPSO-DVSA-LFD. One mechanism is called Dynamic Varying Search Area (DVSA), which takes charge of limiting the ranges of particles’ activity into a reduced area. On the other hand, in order to escape the local optima, Lévy flights are used to generate the stochastic disturbance in the movement of particles. To test the performance of CQPSO-DVSA-LFD, numerical experiments are conducted to compare the proposed algorithm with different variants of PSO. According to the experimental results, the proposed method performs better than other variants of PSO on both benchmark test functions and the combinatorial optimization issue, that is, the job-shop scheduling problem.
Multiorganelle Localization of Metallated Phthalocyanine Photosensitizer in Colorectal Cancer Cells (DLD-1 and CaCo-2) Enhances Efficacy of Photodynamic Therapy
Authors: Sekhejane Palesa Rose , Houreld Nicolette Nadene , Abrahamse Heidi
Published: March 2014

Colorectal cancer is the third most commonly diagnosed cancer. Amongst treatments that have been explored, photodynamic therapy (PDT) is a treatment that is of interest as it poses ideal advantages such as affinity for cancer cells. This study aimed to determine the correlation between the localization site of a sulfonated zinc phthalocyanine (ZnPcSmix) photosensitizer (PS) and its associated cell death pathwayin vitroin colorectal cancer cell lines (DLD-1 and CaCo-2). Visible morphological changes were observed in PDT treated cells after 24 h. Reactive oxygen species (ROS) were detected and visualized 1 h after PDT.ZnPcSmixwas predominantly localized in lysosomes and partially in the mitochondria. FITC Annexin V staining showed a significant decrease in the percentage of viable DLD-1 and CaCo-2 cells 24 h after PDT, with an increase in apoptotic cell population. Moreover, there was a significant increase in both cathepsin D and cytochrome C at 1 and 24 h. In conclusion,ZnPcSmixshowed the ability of inducing apoptotic cell death features in PDT treated cells.
VIM-Based Dynamic Sparse Grid Approach to Partial Differential Equations
Authors: Mei Shu-Li
Published: March 2014

Combining the variational iteration method (VIM) with the sparse grid theory, a dynamic sparse grid approach for nonlinear PDEs is proposed in this paper. In this method, a multilevel interpolation operator is constructed based on the sparse grids theory firstly. The operator is based on the linear combination of the basic functions and independent of them. Second, by means of the precise integration method (PIM), the VIM is developed to solve the nonlinear system of ODEs which is obtained from the discretization of the PDEs. In addition, a dynamic choice scheme on both of the inner and external grid points is proposed. It is different from the traditional interval wavelet collocation method in which the choice of both of the inner and external grid points is dynamic. The numerical experiments show that our method is better than the traditional wavelet collocation method, especially in solving the PDEs with the Nuemann boundary conditions.
Inflorescences of the BromeliadVriesea friburgensisas Nest Sites and Food Resources for Ants and Other Arthropods in Brazil
Authors: Schmid Volker S. , Langner Simone , Steiner Josefina , Zillikens Anne
Published: March 2014

For the first time, the usage of bromeliad inflorescences as nesting sites for ants and other arthropods was studied. Frequencies of occurrence of nests were recorded from hollow stems of dried infructescences of the bromeliadVriesea friburgensison Santa Catarina Island, southern Brazil. Three habitat types were studied: miconietum and two types of restinga, one with low (restinga-low) and one with high vegetation cover (restinga-high). Additionally, flower visitation by ants was examined in restinga-low. Out of 619 infructescences, 33% contained nests. Ants were the most frequent occupants (82–96% of nests), followed by termites (3–18%) and bees (0–0.6%). Species accumulation curves and diversity indices indicate that the diversity of stem-occupying ant species is highest in restinga-low (eight species observed, 18 predicted) and lowest in restinga-high (four observed and predicted). Highest similarity of compositions of infructescence-inhabiting ant species was recorded between miconietum and restinga-high, lowest between restinga-low and restinga-high. Similarity between compositions of inflorescence-visiting and infructescence-inhabiting species in restinga-low was even higher (compared with the cases described in the previous sentence) although 50% of the involved species were present in only one of the samples. Altogether, our results indicate that inflorescences are important resources for ants and other nest-building insects from flowering season to past-fruiting season.
The CdS/CdSe/ZnS Photoanode Cosensitized Solar Cells Basedon Pt, CuS, Cu2S, and PbS Counter Electrodes
Authors: Ha Thanh Tung , Huynh Thanh Dat , Quang Lam Vinh
Published: March 2014

Highly ordered mesoporous TiO2 modified by CdS, CdSe, and ZnS quantum dots (QDs) was fabricated by successive ionic layer adsorption and reaction (SILAR) method. The quantity of material deposition seems to be affected not only by the employed deposition method but also and mainly by the nature of the underlying layer. The CdS, CdSe, and ZnS QDs modification expands the photoresponse range of mesoporous TiO2 from ultraviolet region to visible range, as confirmed by UV-Vis spectrum. Optimized anode electrodes led to solar cells producing high current densities. Pt, CuS, PbS, and Cu2S have been used as electrocatalysts on counter electrodes. The maximum solar conversion efficiency reached in this work was 1.52% and was obtained by using Pt electrocatalyst. CuS, PbS, and Cu2S gave high currents and this was in line with the low charge transfer resistances recorded in their case.
Diabetes and Quality of Life: A Ugandan Perspective
Authors: Nyanzi Ronald , Wamala Robert , Atuhaire Leonard K.
Published: March 2014

Quality of life of diabetic patients is not a new concept in literature. The contentious issue however is whether factors associated in literature with quality of life apply to diabetic patients in Uganda. A sample of 219 outpatients attending Mulago diabetic clinic—a national referral hospital in Uganda—is used to provide an understanding of this issue. Quality of life is assessed in the dimensions of role limitation due to physical health, emotional health, treatment satisfaction, physical endurance, and diet satisfaction based on a five-point Likert scale. The analysis is made by patients’ characteristics, medical conditions, lifestyle factors, and type of medication using frequency distributions, summary statistics, and a Poisson regression. In the results, we confirm a consensus regarding the influence of age and education level on the quality of life in the dimensions of role limitation and physical enduranceP<0.05. A similar conclusion is reached with regards to impact of diabetic foot ulcers in the dimension of physical endurance. Thus, the factors associated with quality of life are not entirely unique to diabetic patients in the country.
Magnetic Circuit Design and Multiphysics Analysis of a Novel MR Damper for Applications under High Velocity
Authors: Zheng Jiajia , Li Zhaochun , Koo JeongHoi , Wang Jiong
Published: March 2014

A novel magnetorheological (MR) damper with a multistage piston and independent input currents is designed and analyzed. The equivalent magnetic circuit model is investigated along with the relation between magnetic induction density in the working gap and input currents of the electromagnetic coils. Finite element method (FEM) is used to analyze the distribution of magnetic field through the MR fluid region. Considering the real situation, coupling equations are presented to analyze the electromagnetic-thermal-flow coupling problems. Software COMSOL is used to analyze the multiphysics, that is, electromagnetic, thermal dynamic, and fluid mechanic. A measurement index involving total damping force, dynamic range, and induction time needed for magnetic coil is put forward to evaluate the performance of the novel multistage MR damper. The simulation results show that it is promising for applications under high velocity and works better when more electromagnetic coils are applied with input currents separately. Besides, in order to reduce energy consumption, it is recommended to apply more electromagnetic coils with relative low currents based on the analysis of pressure drop along the annular gap.
Involvement of Oxidative Stress and Inflammation in Liver Injury Caused by Perfluorooctanoic Acid Exposure in Mice
Authors: Yang Bei , Zou Weiying , Hu Zhenzhen , Liu Fangming , Zhou Ling , Yang Shulong , Kuang Haibin , Wu Lei , Wei Jie , Wang Jinglei , Zou Ting , Zhang Dalei
Published: March 2014

Perfluorooctanoic acid (PFOA) is widely present in the environment and has been reported to induce hepatic toxicity in animals and humans. In this study, mice were orally administered different concentrations of PFOA (2.5, 5, or 10 mg/kg/day). Histological examination showed that the exposure to PFOA for 14 consecutive days led to serious hepatocellular injury and obvious inflammatory cell infiltration. In addition, malondialdehyde formation and hydrogen peroxide generation, indicators of oxidative stress, were significantly induced by PFOA treatment in the liver of mice. Furthermore, hepatic levels of interleukin-6, cyclooxygenase-2, and C-reactive protein, markers of inflammatory response, were markedly increased by exposure to PFOA in mice. These results demonstrated that PFOA-induced hepatic toxicity may be involved in oxidative stress and inflammatory response in mice.
Determination of Polyphenol Components of Korean Prostrate Spurge (Euphorbia supina) by Using Liquid Chromatography—Tandem Mass Spectrometry: Overall Contribution to Antioxidant Activity
Authors: Song Yi , Jeong Sung Woo , Lee Won Sup , Park Semin , Kim Yun-Hi , Kim Gon-Sup , Lee Soo Jung , Jin Jong Sung , Kim Chi-Yeon , Lee Ji Eun , Ok Se Yun , Bark Ki-Min , Shin Sung Chul
Published: March 2014

The Korean prostrate spurgeEuphorbia supinais a weed that has been used in folk medicine in Korea against a variety of diseases. Nine polyphenols were characterized for this plant by using high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) and the results were compared with the literature data. The individual components were validated using the calibration curves of structurally related external standards and quantified for the first time by using the validated method. Correlation coefficients (r2) were >0.9907. The limit of detection and limit of quantification of the method were >0.028 mg/L and 0.094 mg/L, respectively. Recoveries measured at 50 mg/L and 100 mg/L were 76.1–102.8% and 85.2–98.6%, respectively. The total amount of the identified polyphenols was 3352.9 ± 2.8 mg/kg fresh plant. Quercetin and kaempferol derivatives formed 84.8% of the total polyphenols. The antioxidant activities of the flavonoids were evaluated in terms of 1,1-diphenyl-2-picrylhydrazyl and 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) radical cation-scavenging activity, and the reducing power showed a dose-dependent increase. Cell viability was effectively suppressed at polyphenol mixture concentrations >250 mg/L.
An Optimal Control Problem of Forward-Backward Stochastic Volterra Integral Equations with State Constraints
Authors: Wei Qingmeng , Xiao Xinling
Published: March 2014

This paper is devoted to the stochastic optimal control problems for systems governed by forward-backward stochastic Volterra integral equations (FBSVIEs, for short) with state constraints. Using Ekeland's variational principle, we obtain one kind of variational inequalities. Then, by dual method, we derive a stochastic maximum principle which gives the necessary conditions for the optimal controls.
Photoprotective Effect of the PlantCollaea argentinaagainst Adverse Effects Induced by Photodynamic Therapy
Authors: Mamone Leandro , Sáenz Daniel , Vallecorsa Pablo , Batlle Alcira , Casas Adriana , Di Venosa Gabriela
Published: March 2014

Photodynamic therapy (PDT) is a treatment modality for tumours and other accessible lesions based on the combination of light and a photosensitizer (PS) accumulated in the target tissue. The main disadvantage of PDT is PS retention after treatment during long time periods that conduces to cutaneous damage. It is believed that singlet oxygen is responsible for that skin photosensitization. The aim of this work was to evaluate the photoprotective activity of the methanolic extract of the Argentinian plantCollaea argentinaagainst PDT under several treatments and employing different PSs.C. argentinaexhibited photoprotective activity against aminolevulinic acid- (ALA-) PDT in the LM2 murine adenocarcinoma cell line. The photoprotection was dependant on the extract concentration and the incubation time, being detectable from 40 μg/mL onwards and at least after 3 h exposure of the cells.C. argentinaextract protects these mammalian tumor cells against PDT effects, and it interferes with the oxygen singlet production from PSs during PDT treatment. We propose that it will be a promising agent to protect cells against PDT-induced skin sensitivity.
Discussions on Recent Results forα-ψ-Contractive Mappings
Authors: Hussain N. , Kutbi M. A. , Khaleghizadeh S. , Salimi P.
Published: March 2014

We establish certain fixed point results forα-η-generalized convex contractions,α-η-weakly Zamfirescu mappings, andα-η-Ćirić strong almost contractions. As an application, we derive some Suzuki type fixed point theorems and certain new fixed point theorems in metric spaces endowed with a graph and a partial order. Moreover, we discuss some illustrative examples to highlight the realized improvements.
Stem Cell-Based Therapies for Ischemic Stroke
Authors: Hao Lei , Zou Zhongmin , Tian Hong , Zhang Yubo , Zhou Huchuan , Liu Lei
Published: March 2014

In recent years, stem cell-based approaches have attracted more attention from scientists and clinicians due to their possible therapeutical effect on stroke. Animal studies have demonstrated that the beneficial effects of stem cells including embryonic stem cells (ESCs), inducible pluripotent stem cells (iPSCs), neural stem cells (NSCs), and mesenchymal stem cell (MSCs) might be due to cell replacement, neuroprotection, endogenous neurogenesis, angiogenesis, and modulation on inflammation and immune response. Although several clinical studies have shown the high efficiency and safety of stem cell in stroke management, mainly MSCs, some issues regarding to cell homing, survival, tracking, safety, and optimal cell transplantation protocol, such as cell dose and time window, should be addressed. Undoubtably, stem cell-based gene therapy represents a novel potential therapeutic strategy for stroke in future.
Folic Acid Supplementation and Preterm Birth: Results from Observational Studies
Authors: Mantovani Elena , Filippini Francesca , Bortolus Renata , Franchi Massimo
Published: March 2014

Introduction. Folic acid (FA) supplementation is recommended worldwide in the periconceptional period for the prevention of neural tube defects. Due to its involvement in a number of cellular processes, its role in other pregnancy outcomes such as miscarriage, recurrent miscarriage, low birth weight, preterm birth (PTB), preeclampsia, abruptio placentae, and stillbirth has been investigated. PTB is a leading cause of perinatal mortality and morbidity; therefore its association with FA supplementation is of major interest. The analysis of a small number of randomized clinical trials (RCTs) has not found a beneficial role of FA in reducing the rate of PTBs.Aim of the Study. The aim of this review was to examine the results from recent observational studies about the effect of FA supplementation on PTB.Materials and Methods. We carried out a search on Medline and by manual search of the observational studies from 2009 onwards that analyzed the rate of PTB in patients who received supplementation with FA before and/or throughout pregnancy.Results. The results from recent observational studies suggest a slight reduction of PTBs that is not consistent with the results from RCTs. Further research is needed to better understand the role of FA supplementation before and during pregnancy in PTB.
Quantum Neural Network Based Machine Translator for Hindi to English
Authors: Narayan Ravi , Singh V. P. , Chakraverty S.
Published: March 2014

This paper presents the machine learning based machine translation system for Hindi to English, which learns the semantically correct corpus. The quantum neural based pattern recognizer is used to recognize and learn the pattern of corpus, using the information of part of speech of individual word in the corpus, like a human. The system performs the machine translation using its knowledge gained during the learning by inputting the pair of sentences of Devnagri-Hindi and English. To analyze the effectiveness of the proposed approach, 2600 sentences have been evaluated during simulation and evaluation. The accuracy achieved on BLEU score is 0.7502, on NIST score is 6.5773, on ROUGE-L score is 0.9233, and on METEOR score is 0.5456, which is significantly higher in comparison with Google Translation and Bing Translation for Hindi to English Machine Translation.
Expression of Mesenchymal Stem Cells-Related Genes and Plasticity of Aspirated Follicular Cells Obtained from Infertile Women
Authors: Dzafic Edo , Stimpfel Martin , Novakovic Srdjan , Cerkovnik Petra , Virant-Klun Irma
Published: March 2014

After removal of oocytes forin vitrofertilization, follicular aspirates which are rich in somatic follicular cells are discarded in daily medical practice. However, there is some evidence that less differentiated cells with stem cell characteristics are present among aspirated follicular cells (AFCs). The aim of this study was to culture AFCsin vitroand to analyze their gene expression profile. Using the RT2Profiler PCR array, we investigated the expression profile of 84 genes related to stemness, mesenchymal stem cells (MCSs), and cell differentiation in AFCs enriched by hypoosmotic protocol from follicular aspirates of infertile women involved in assisted reproduction programme in comparison with bone marrow-derived mesenchymal stem cells (BM-MSCs) and fibroblasts. Altogether the expression of 57 genes was detected in AFCs: 16 genes (OCT4,CD49f,CD106,CD146,CD45,CD54,IL10,IL1B,TNF,VEGF,VWF,HDAC1,MITF,RUNX2,PPARG, andPCAF) were upregulated and 20 genes (FGF2,CASP3,CD105,CD13,CD340,CD73,CD90,KDR,PDGFRB,BDNF,COL1A1,IL6,MMP2,NES,NUDT6,BMP6,SMURF2,BMP4,GDF5, andJAG1) were downregulated in AFCs when compared with BM-MSCs. The genes which were upregulated in AFCs were mostly related to MSCs and connected with ovarian function, and differed from those in fibroblasts. The cultured AFCs with predominating granulosa cells were successfullyin vitrodifferentiated into adipogenic-, osteogenic-, and pancreatic-like cells. The upregulation of some MSC-specific genes andin vitrodifferentiation into other types of cells indicated a subpopulation of AFCs with specific stemness, which was not similar to those of BM-MSCs or fibroblasts.
An Overview: Recent Development of Titanium Oxide Nanotubes as Photocatalyst for Dye Degradation
Authors: Lai Chin Wei , Juan Joon Ching , Ko Weon Bae , Bee Abd Hamid Sharifah
Published: March 2014

Today, organic dyes are one of the largest groups of pollutants release into environment especially from textile industry. It is highly toxic and hazardous to the living organism; thus, the removal of these dyes prior to discharge into the environment is essential. Varieties of techniques have been employed to degrade organic dyes and heterogeneous photocatalysis involving titanium dioxide (TiO2) appears to be the most promising technology. In recent years, TiO2nanotubes have attracted much attention due to their high surface area and extraordinary characteristics. This paper presents a critical review of recent achievements in the modification of TiO2nanotubes for dye degradation. The photocatalytic activity on dye degradation can be further enhanced by doping with cationic or anionic dopant.
Acute Exacerbation of Chronic Obstructive Pulmonary Disease: Cardiovascular Links
Authors: Laratta Cheryl R. , van Eeden Stephan
Published: March 2014

Chronic obstructive pulmonary disease (COPD) is a chronic, progressive lung disease resulting from exposure to cigarette smoke, noxious gases, particulate matter, and air pollutants. COPD is exacerbated by acute inflammatory insults such as lung infections (viral and bacterial) and air pollutants which further accelerate the steady decline in lung function. The chronic inflammatory process in the lung contributes to the extrapulmonary manifestations of COPD which are predominantly cardiovascular in nature. Here we review the significant burden of cardiovascular disease in COPD and discuss the clinical and pathological links between acute exacerbations of COPD and cardiovascular disease.
Marginal and Internal Fit of Cobalt-Chromium Fixed Dental Prostheses Generated from Digital and Conventional Impressions
Authors: Svanborg Per , Skjerven Henrik , Carlsson Pablo , Eliasson Alf , Karlsson Stig , Örtorp Anders
Published: March 2014

Objectives. Digital impressions are increasingly used and have the potential to avoid the problem of inaccurate impressions. Only a few studies to verify the accuracy of digital impressions have been performed. The purpose of this study was to compare the marginal and internal fit of 3-unit tooth supported fixed dental prostheses (FDPs) fabricated from digital and conventional impressions.Methods. Ten FDPs were produced from digital impressions using the iTero system and 10 FDPs were produced using vinyl polysiloxane (VPS) impression material. A triple-scan protocol and CAD software were used for measuring and calculating discrepancies of the FDPs at 3 standard areas: mean internal discrepancy, absolute marginal gap, and cervical area discrepancy. The Mann-Whitney U test was used for analyzing the results.Results. For conventional and digital impressions, respectively, FDPs had an absolute marginal gap of 147 μm and 142 μm, cervical area discrepancy of 69 μm and 44 μm, and mean internal discrepancy of 117 μm and 93 μm. The differences were statistically significant in the cervical and internal areas (P<0.001).Significance. The results indicated that the digital impression technique is more exact and can generate 3-unit FDPs with a significantly closer fit compared to the VPS technique.
Bifurcation Analysis of a Delayed Predator-Prey Model with Holling Type III Functional Response and Predator Harvesting
Authors: Das Uttam , Kar T. K.
Published: March 2014

This paper tries to highlight a delayed prey-predator model with Holling type III functional response and harvesting to predator species. In this context, we have discussed local stability of the equilibria, and the occurrence of Hopf bifurcation of the system is examined by considering the harvesting effort as bifurcation parameter along with the influences of harvesting effort of the system when time delay is zero. Direction of Hopf bifurcation and the stability of bifurcating periodic solutions are also studied by applying the normal form theory and the center manifold theorem. Lastly some numerical simulations are carried out to draw for the validity of the theoretical results.
Development of a Promising Fish Model (Oryzias melastigma) for Assessing Multiple Responses to Stresses in the Marine Environment
Authors: Dong Sijun , Kang Mei , Wu Xinlong , Ye Ting
Published: March 2014

With the increasing number of contaminants in the marine environment, various experimental organisms have been “taken into labs” by investigators to find the most suitable environmentally relevant models for toxicity testing. The marine medaka,Oryzias melastigma, has a number of advantages that make it a prime candidate for these tests. Recently, many studies have been conducted on marine medaka, especially in terms of their physiological, biochemical, and molecular responses after exposure to contaminants and other environmental stressors. This review provides a literature survey highlighting the steady increase of ecotoxicological research on marine medaka, summarizes the advantages of usingO. melastigmaas a tool for toxicological research, and promotes the utilization of this organism in future studies.
Effects of Probiotics, Prebiotics, and Synbiotics on Hypercholesterolemia: A Review
Authors: Anandharaj Marimuthu , Sivasankari Balayogan , Parveen Rani Rizwana
Published: March 2014

Cholesterol plays a major role in human health. High cholesterol is a leading risk factor for human cardiovascular disease such as atherosclerosis, coronary heart disease, and stroke. Excess cholesterol in the bloodstream can form plaque in the artery walls. Hypercholesterolemia is a major risk factor for the development of atherosclerosis. A number of pharmacological and non-pharmacological (including dietary) approaches being employed to reduce the cholesterol level. Numerous drugs that lower serum cholesterol have been developed to treat hypercholesterolemic patients, the best example being the statins drugs (Atorvastatin, Simvastatin, Rosuvastatin, and Lovastatin). However, the undesirable side effects of these compounds were observed and have caused concern about their long term therapeutic use. Several studies have been reported that the consumption of fermented dairy products decreases serum cholesterol. Probiotics are live microorganisms that promote health benefits upon consumption, while prebiotics are nondigestible food ingredients that selectively stimulate the growth of beneficial microorganisms in the gastrointestinal tract. Probiotics and prebiotics have been suggested to reduce cholesterol via various mechanisms without any deleterious effect to the human health. This paper may throw some light to prove the ability of these synbiotics as a novel alternative or adjuvant to chemical drugs to help fight the hypercholesterolemic problem.
Intelligent Integration between Human Simulated Intelligence and Expert Control Technology for the Combustion Process of Gas Heating Furnace
Authors: Liu Yucheng , Liu Yubin
Published: March 2014

Due to being poor in control quality of the combustion process of gas heating furnace, this paper explored a sort of strong robust control algorithm in order to improve the control quality of the combustion process of gas heating furnace. The paper analyzed the control puzzle in the complex combustion process of gas heating furnace, summarized the cybernetics characteristic of the complex combustion process, researched into control strategy of the uncertainty complex control process, discussed the control model of the complex process, presented a sort of intelligent integration between human‐simulated intelligence and expert control technology, and constructed the control algorithm for the combustion process controlling of gas heating furnace. The simulation results showed that the control algorithm proposed in the paper is not only better in dynamic and steady quality of the combustion process, but also obvious in energy saving effect, feasible, and effective in control strategy.
Thioredoxin System Regulation in the Central Nervous System: Experimental Models and Clinical Evidence
Authors: Silva-Adaya Daniela , Gonsebatt María E. , Guevara Jorge
Published: March 2014

The reactive oxygen species produced continuously during oxidative metabolism are generated at very high rates in the brain. Therefore, defending against oxidative stress is an essential task within the brain. An important cellular system against oxidative stress is the thioredoxin system (TS). TS is composed of thioredoxin, thioredoxin reductase, and NADPH. This review focuses on the evidence gathered in recent investigations into the central nervous system, specifically the different brain regions in which the TS is expressed. Furthermore, we address the conditions that modulate the thioredoxin system in both, animal models and the postmortem brains of human patients associated with the most common neurodegenerative disorders, in which the thioredoxin system could play an important part.
NovelSMAD3Mutation in a Patient with Hypoplastic Left Heart Syndrome with Significant Aortic Aneurysm
Authors: Fitzgerald Kristi K. , Bhat Abdul Majeed , Conard Katrina , Hyland James , Pizarro Christian
Published: March 2014

Aneurysms-osteoarthritis syndrome (AOS) caused by haploinsufficiency ofSMAD3is a recently described cause of syndromic familial thoracic aortic aneurysm and dissection (TAAD). We identified a novelSMAD3mutation in a patient with hypoplastic left heart syndrome (HLHS) who developed progressive aortic aneurysm requiring surgical replacement of the neoaortic root, ascending aorta, and proximal aortic arch. Family screening for the mutation revealed that his father, who has vascular and skeletal features of AOS, and his brother, who is asymptomatic, also have the pathogenic mutation. This is the first case report of aSMAD3mutation in a patient with hypoplastic left heart syndrome. This case highlights the importance of genetic testing for known causes of aneurysm in patients with congenital heart disease who develop aneurysmal disease as it may significantly impact the management of those patients and their family members.
Optimization Problems of Costs in a MultiState System with Imperfect Maintenance
Authors: Gasmi Soufiane , Mannai Nizar
Published: March 2014

We consider optimal replacement policies with periodic imperfect maintenance actions and minimal repairs. The multistate system is minimally repaired at failure and imperfect maintenance actions are regularly carried out for preventive maintenance. The discrete modified Weibull distribution is introduced and some cost functions applied to this distribution are defined in order to be minimized. Moreover, we assume that the costs of preventive maintenance depend on the degree of repair via a Kijima type 2 model. For illustrative purpose, the obtained results are applied on sets of simulated data.
Clinical Characteristics and Surgical Prognosis of Hepatocellular Carcinoma with Bile Duct Invasion
Authors: Meng Ke-Wei , Dong Mei , Zhang Wei-Guo , Huang Qing-Xian
Published: March 2014

Objectives.Bile duct invasion (BDI) is a rare event in hepatocellular carcinoma (HCC). The present study aimed at investigating clinical characteristics and surgical outcome of HCC patients with bile duct invasion.Methods.413 patients with HCC undergoing curative surgery were divided into two groups with (B+) and without BDI (B−). BDI was further classified as central type (B1) and peripheral type (B2). Survival was compared, and risk factors affecting prognosis were identified.Results.35 (8.5%) patients were diagnosed BDI. Total bilirubin was significantly higher in B+group than in B−group (P<0.001). Multiple lesions and large nodules (>5 cm) were predominantly identified in B+group (P<0.01, resp.). Portal vein invasion was more frequently observed in B+than in B−group (P=0.003). Univariate and multivariate analyses identified central BDI as a significant factor affecting prognosis of HCC patients (risk 1.3, 95% CI 1.1–2.2,P=0.015). The gross overall survival of patients in B+was significantly worse than in B−(P=0.001), which, however, was not different between B2 and B−(P>0.05).Conclusions.Central but not peripheral BDI was associated with poorer prognosis of HCC patients. Curative surgical resection of tumors and invaded bile duct supplies the only hope for long-term survival of patients.
Nanocrystalline Al Composites from Powder Milled under Ammonia Gas Flow
Authors: Cintas J. , Caballero E. S. , Montes J. M. , Cuevas F. G. , Arevalo C.
Published: March 2014

The production of high hardness and thermally stable nanocrystalline aluminium composites is described. Al powder was milled at room temperature in an ammonia flow for a period of less than 5 h. NH3dissociation during milling provokes the absorption, at a high rate, of nitrogen into aluminium, hardening it by forming a solid solution. Controlled amounts of AlN and Al5O6N are formed during the subsequent sintering of milled powders for consolidation. The pinning action of these abundant dispersoids highly restrains aluminium grain growth during heating. The mean size of the Al grains remains below 45 nm and even after the milled powder is sintered at 650°C for 1 h.
The Dynamic of the Apical Ectoplasmic Specialization between Spermatids and Sertoli Cells: The Case of the Small GTPase Rap1
Authors: Berruti Giovanna , Paiardi Chiara
Published: March 2014

Despite advances in assisted reproductive technologies, infertility remains a consistent health problem worldwide. Spermiation is the process through which mature spermatids detach from the supporting Sertoli cells and are released into the tubule lumen. Spermiation failure leads to lack of mature spermatozoa and, if not occasional, could result into azoospermia, major cause of male infertility in human population. Spermatids are led through their differentiation into spermatozoa by the apical ectoplasmic specialization (aES), a testis-specific, actin-based anchoring junction restricted to the Sertoli-spermatid interface. The aES helps spermatid movement across the seminiferous epithelium, promotes spermatid positioning, and prevents the release of immature spermatozoa. To accomplish its functions, aES needs to undergo tightly and timely regulated restructuring. Even if components of aES are partly known, the mechanism/s through which aES is regulated remains still elusive. In this review, we propose a model by which the small GTPase Rap1 could regulate aES assembly/remodelling. The characterization of key players in the dynamic of aES, such as Rap1, could open new possibility to develop prognostic, diagnostic, and therapeutic approaches for male patients under treatment for infertility as well as it could lead to the identification of new target for male contraception.
Portland Cement Use in Dental Root Perforations: A Long Term Followup
Authors: Borges Álvaro Henrique , Bandeca Matheus Coelho , Tonetto Mateus Rodrigues , Faitaroni Luis Augusto , Carvalho Elibel Reginna de Siqueira , Guerreiro-Tanomaru Juliane Maria , Tanomaru Filho Mário
Published: March 2014

Root canal and furcal perforations are causes of endodontic therapy failure and different materials that stimulate tissue mineralization have been proposed for perforation treatment. In the first case, a patient presented tooth 46 with unsatisfactory endodontic treatment and a periapical radiographic lesion. A radiolucent area compatible with a perforating internal resorption cavity was found in the mesial root. The granulation tissue was removed, and root canals were prepared. The intracanal medication was composed of calcium hydroxide and the perforation cavity was filled with Portland cement. The 11-year followup showed radiographic repair of the tissue adjacent to the perforation and absence of clinical signs and symptoms or periapical lesion. In the second case, a patient presented with edema on the buccal surface of tooth 46. The examination showed a radiolucent area in the furcation region compatible with an iatrogenic perforation cavity. The mesial root canals were calcified, and only the distal root canal was prepared. The cavity was filled with a calcium hydroxide-based paste and the distal root canal was obturated. In sequence, the perforation cavity was filled with Portland cement. The 9-year followup showed the tooth in masticatory function with radiographic and clinical aspects compatible with normality.
Trends of Convective and Stratiform Precipitation in the Czech Republic, 1982–2010
Authors: Rulfová Zuzana , Kyselý Jan
Published: March 2014

The study examines trends in characteristics of convective and stratiform precipitation in the Czech Republic over 1982–2010. The spatially averaged trends in convective precipitation are rising for indices of mean precipitation, and the increases are significant in all seasons except for winter. For extremes, the trends are spatially much more variable and insignificant, but increases tend to prevail as well. The trends in convective precipitation are larger in the western part of the country where Atlantic influences are stronger. For characteristics of stratiform precipitation, the trends are usually smaller compared to those of convective precipitation, but increases prevail too. They are significant in autumn, especially for extremes, and larger in the eastern part of the country where Mediterranean cyclones play more important role. The trends in convective precipitation tend to be more pronounced at lowland than higher-elevated stations while an opposite pattern prevails for stratiform precipitation. The results suggest that in spring and summer, when convective precipitation represents an important fraction of the total amounts in central Europe (around 30% and 50%, respectively), the observed increases in total precipitation are mainly due to increases in convective precipitation. In autumn, increases in both convective and stratiform precipitation are important, and the trends are weakest and least pronounced in winter.