bluuebunny/crossref_metadata_2025 huggingface dataset:
PALEOGEN DAVRI YOTQIZIQLARIDA TARQALGAN FOYDALI QAZILMA KONLARINING LITOLOGIK-FATSIAL SHAROITGA BOG‘LIQLIGI
Authors: Po‘latjon SULTONOV,  , Bahodir MELIBOYEV,  , Nilufar GAFFAROVA
Published: June 2024

Maqolada oxirgi yillar davomida to‘plangan ko‘plab burg‘i quduqlari ma’lumotlariga asoslanib, Farg‘ona botig‘i va Toshkentoldi hududlarida tarqalgan paleogen davri yotqiziqlarining o‘ziga hos litologik, petrografik, stratigrafik va fatsial  hususiyatlari hamda noruda foydali qazilmalarga istiqbolliligini o‘rganish natijalari yoritilgan.
РЕЗУЛЬТАТЫ ОПЫТНО-ПРОМЫШЛЕННОГО ИСПЫТАНИЯ НОВОГО ИНГИБИТОРА КОРРОЗИИ МАРКИ ИК-GRDC-0421 НА МЕСТОРОЖДЕНИИ СЕВЕРНЫЙ УРТАБУЛАК
Authors: Максад ТУРСУНОВ  , Акмал АБДИРАЗАКОВ  , Қуддуз КЕНЖАЕВ
Published: June 2024

В статье представлены результаты промысловых испытаний нового ингибитора коррозии разработанный для защиты оборудования и коммуникации, находящихся в средах с высокой солевой минерализацией, содержащих углекислый газ, кислород, сероводород и другие агрессивные примеси.
СИНТЕЗ И ИССЛЕДОВАНИЕ КОМПЛЕКСНЫХ СОЕДИНЕНИЙ ЦИНКА, КАДМИЯ И СВИНЦА (II) С 1-(2-ПИРИДИЛАЗО)-2-НАФТОЛОМ
Authors: Гулчехра АБДУЛЛАЕВА  , Сардор МУРОДОВ  , Шахло ДАМИНОВА
Published: June 2024

Синтезированы и исследованы комплексные соединения цинка, кадмия и свинца c 1-(2-пиридилазо)-2-нафтолом. Состав и строение полученных комплексных соединений установлены методами ICP-OES,  рентгенофлуоресцентного анализа, сканирующей электронной микроскопии с энергодисперсионным анализом, ИК-спектроскопии, дифференциально-термическим анализом, а также квантовохимическими расчетными методами. Были установлены, что в комплексах M:L вступает в реакцию в соотношениях 1:2.
OLISH SUV EMULSIYALARI STOKIYOMETRIK BO'LMAGAN INTERPOLIMERIK KOMPLEKSLAR VA KOMPOZITLARDAN VA ULARDAN FOYDALANISH
Authors: Baxtiyor YODGOROV  , Kamariddin KOMILOV,  , G'afurjon MUHAMEDOV
Published: June 2024

Ushbu maqolada karbamid-formaldegid oligomerlari (KFO) va karboksimetilselüloz natriy tuzi (Na-KMC) asosida stokiyometrik bo'lmagan interpolimer komplekslaridan (NIPK) suv emulsiyalarini olish va ularning tarkibini o'rganish tahlil qilinadi.va xususiyatlari va suvning yutuvchi elementi sifatida qo'llanilishi va tuproqning metabolik jarayonining tuzini yaxshilaydi. Tadqiqot natijalariga ko'ra, tuproq yuzasida yaratilgan NIPK filtrlashga qarshi ekran orqali paxtani sug'orishda, hisoblangan qatlam ostidagi suvning chuqur filtratsiyasi sug'orish stavkalarining 30-35% ga kamayishi aniqlandi.
ЭНЕРГОСБЕРЕГАЮЩАЯ ТЕХНОЛОГИЯ ПРОИЗВОДСТВА КОРМОВОГО МОНОКАЛЬЦИЙФОСФАТА НА ОСНОВЕ ЭКСТРАКЦИОННОЙ ФОСФОРНОЙ КИСЛОТЫ И ИЗВЕСТНЯКА
Authors: Гавхар МЕЛИКУЛОВА,  , Холтура МИРЗАКУЛОВ,  , Аъзамжон НАСРИДДИНОВ,  , Баходир САДЫКОВ,
Published: June 2024

Целью исследования является разработка энергосберегающей технологии получения кормового монокальцийфосфата путем одновременного концентрирования и глубокого обесфторивания экстракционной фосфорной кислоты в присутствии кислотнорастворимой окиси кремния и разложением известняка очищенной кислотой. Установлены оптимальные технологические параметры, способы подачи теплоносителя и виды выпарного аппарата, при которых степень обесфторивания - более 99,0%. Получен на её основе кормовой монокальцийфосфат, определены их физико-химические характеристики, разработаны технологические схемы и составлен материальный баланс.
ДОЛОМИТНИНГ СУЛФАТ КИСЛОТАДА ПАРЧАЛАНИШИДАГИ МАҲСУЛОТЛАРИНИНГ РЕОЛОГИК ХУСУСИЯТЛАРИ ВА ФИЛЬТРЛАНИШИНИ ЎРГАНИШ
Authors: Холтура МИРЗАКУЛОВ  , Ойбек МИХЛИЕВ  , Атаназар СЕЙТНАЗАРОВ
Published: June 2024

v
The results of studying the rheological properties, as well as settling and filtration of decomposition products (pulp and liquid phase) of dolomite from the Dekhkanabad deposit with sulfuric acid are presented. It has been shown that the sedimentation of large particles of undecomposed dolomite proceeds quite quickly and after 3 minutes the degree of precipitation is 100%, while the suspension settles slowly and after 120 minutes the degree of clarification reaches 86.83%. For temperatures of 20-80ºС, the density of the clarified solution varies in the range of 1,362-1.444 g/cm3, and the viscosity is 1.80-4.97 cP.
MAHALLIY XOMASHYOLAR ASOSIDAGI KARBOMID VA AMMOFOS ASOSIDAGI AK-1 MARKALI OLIGOMER ADDUKT OLISH, OLINGAN MATERIALLARNING OLOVBARDOSHLIGINI OSHIRISH
Authors: Rustam SADIKOV  , Fayzulla NURQULOV  , Abdulahad DJALILOV
Published: June 2024

Mahalliy xomashyolar asosidagi karbomid va ammofos asosida addukt olindi, uning fizik-kimyoviy xususiyatlarini о‘rganildi.Olingan tatqiqotlar natijasida AK-1 oligomerning oquvchanligi aniqlandi.
ASOSIDA POLIETILEN BO‘LGAN METALL TO‘LDIRUVCHILI NANOKOMPOZIT POLIMERLARNING TUZILISHINI O‘RGANISH
Authors: Xaqberdi XAMZAYEV
Published: June 2024

Ushbu maqolada nanokompozitlarning kadmiy zarralari hajm bo‘yicha metallpolimer tarkibida deyarli teng ravishda  taqsimlanishi tajribada aniqlandi.
ИЗУЧЕНИЕ ФИЗИКО-ХИМИЧЕСКИХ СВОЙСТВ СУСПЕНЗИИ, ОБРАЗУЮЩЕЙСЯ ПРИ БЕСФТОРИРОВАНИИ ЭКСТРАКЦИОННОЙ ФОСФОРНОЙ КИСЛОТЫ И РАЗЛИЧНЫХ КОЭФФИЦИЕНТЫ ПАРАМЕТРАХ ПРОЦЕССА ФИЛЬТРАЦИИ
Authors: Сахомиддин ХОДЖАМКУЛОВ  , Холтура МИРЗАКУЛОВ  , Сирожиддин ЗОИРОВ  , Мохичехра ШАЙМАРДАНОВА,
Published: June 2024

В статье приведены данные по разработке технологии обесфторивания и обессульфачивания экстракционной фосфорной кислоты из фосфоритов Центральных Кызылкумов солями натрия. Изучены реологические свойства суспензии, фильтруемость пульпы. Установлены оптимальные нормы технологического режима, при которых массовое соотношение Ж:Т в суспензии не выше 7:1, перепад давлений ∆Р-70-80 кПа, концентрация полиакриламида в суспензии 2,0-3,5 мг/л, высота слоя осадка на фильтре – 0,01 м.
GIBRID DIATSETATSELLYULOZA-KREMNEZEM BIONANOKOMPOZITSIYASIGA N-GEPTAN MOLEKULASINING ADSORBSIYALANISHI
Authors: Axror YARKULOV
Published: June 2024

Gibrid DAS-kremnezem bionanokompozitsiyasiaga 303 К temperaturada n-geptan molekulasini adsorbsiyalanish izotermasi boshlangʻich qismdan to toʻyinishgacha mikrogʻovaklarning hajmiy toʻyinish nazariyasining (MHTN) uch hadli tenglamasi bilan tavsiflandi. Gibrid DAS-kremnezem bionanokompozitsiyasiaga n-geptan molekulasini adsorbsiyalanishining differensial issiqligi pogʻonasimon koʻrinishda hamda issiqlik miqdori 94 kJ/mol ga teng boʻlgan adsorbent-adsorbat, adsorbat miqdori 0,5 mmol/g dan soʻng adsorbat-adsorbat ta’sirlashish sodir boʻlib, polimolekulyar adsorbsiyalanish sodir boʻlayotganligi aniqlandi. Differensial molyar entropiya egrisi n-geptan bugʻi molekulalarining adsorbentdagi holati 0,55 mmol/g gacha mustahkam holatda joylashganligini koʻrsatdi.
STRATEGI PEMASARAN DAN PENGEMBANGAN PRODUK UMKM ULOS DI UD. STEVEN PARDEDE
Authors: Dian G Purba  , Angelina Simbolon  , Yusy Prita Hizkia Purba
Published: June 2024

The development of Micro, Small and Medium Enterprises (MSMEs) is an important effort to support the local economy and strengthen the sustainability of local culture. This study explores the marketing strategy and product development of Ulos MSMEs at UD. Steven Pardede, located in jl.Musyawarah No.9 the North Sumatra region, Indonesia. This research uses a qualitative approach by conducting in-depth interviews and direct observations of business owners and related staff. The research results show that UD. Steven Pardede implements a marketing strategy that focuses on strengthening the brand image, increasing product visibility through exhibitions and social media, as well as utilizing partnerships with shops and other companies in distributing their Ulos Batak products. Apart from that, the company also invests in product development through design innovation and product diversification according to market demand. This research provides valuable insight into best practices in marketing and developing Ulos MSME products, as well as highlighting the importance of adapting to market and technological changes in strengthening the competitiveness of MSMEs in the era of globalization. The practical implications of these findings include recommendations for implementing more effective digital marketing strategies and strengthening industry partnerships to support the growth of Ulos MSMEs in local and international markets.
KONSEP HOTEL SYARIAH DALAM PERSPEKTIF FIQH ISLAM KONTEMPORER
Authors: Asyifa Alibia  , Hadiat
Published: June 2024

The concept of a sharia hotel has developed into a trend in the hospitality business today, in big cities there have been many sharia hotels. The purpose of this research is to analyze the concept of sharia hotel in contemporary fiqh perspective. The research method used is library research. Data were collected through observation and documentation, then analyzed by qualitative analysis. The results of the study show that the criteria for the sharia hotel concept that are suitable for use are in accordance with the rules, namely: Syiar and Appearance, Facilities, Worship and Da'wah, Managerial and Finance. The concept of a shari'ah hotel is in line with the times or contemporary, adapting to the rules based on the Qur'an. adapted to current conditions.
ANALISIS PENEGAKAN HUKUM EKONOMI SYARIAH TERHADAP JUAL BELI MINYAK GORENG SEMAKIN MEROKET DI MASA PANDEMI COVID-19
Authors: Muslih  , Andre Pebrian Perdana
Published: June 2024

Due to the current COVID-19 pandemic, there have been many increases in the prices of basic goods such as cooking oil. Indeed, Islam has provided a solution in overcoming the price increase. If the soaring price of basic necessities is caused by natural factors that cause a scarcity of an item, besides this, people are required to be patient. And in Islam it also obliges the state to overcome this scarcity by seeking supplies from other regions, even Islam forbids people who do not understand fiqh law (related to business) from doing business. In this study, the author uses a normative legal research method that relies on literature studies and the focus is on analyzing primary and secondary legal materials. Where primary legal materials are applicable legal regulations and legal cases, while secondary legal materials include legal opinions contained in legal books and journals.
MEMBANGUN LITERASI KEUANGAN DAN INVESTASI SYARI'AH
Authors: Muna Rifatul
Published: June 2024

Investment in general is to invest or place assets, both in the form of assets and funds, in something that is expected to provide income or will increase its value in the future. investing is investing or placing assets, either in the form of assets or funds, in something that is expected to generate income or increase its value in the future. The formulation of the problem of this research is what is the role of sharia investment in driving economic growth in the non-real sector. The aim of this research is to find out the potential of Islamic investment in encouraging economic growth in the non-real sector. This study uses qualitative research with descriptive research types, then for the subject in this study is Islamic investment, in collecting data using methods, observation, and documentation. The results of this study indicate that the development of Islamic investment has increased the demand for Islamic investment. the large number of requests from foreign trade has had the effect of strengthening the rupiah exchange rate against the US dollar, by strengthening the value of coal, gold, silver and other new mines.
Bentuk dan Makna Tuturan Upacara Pelulukng Suku Dayak Benuaq di Kalimantan Timur
Authors: Sulityowati Endang Dwi , Mulawarman Widyatmike Gede , Rokhmansyah Alfian , Sari Amalia
Published: June 2024

This study aims to understand the form and meaning of speech in the Dayak Benuaq tribe's Pelulukng (Traditional Marriage) ceremony. The method used in this research is the semiotic method which is used to understand the form and meaning of speech, especially icons, symbols, and indexes. Data collection methods used include observation and interviews, as well as using tapping techniques. From the research results, it was found that eleven utterances in the form of icons, twelve in the form of an index, and twelve words in the speech in the form of symbols. First, the speech in the form of an icon is a form of action from the Pemeliant because it has similarities or similarities between the speech and the actions taken. Second, speech in the form of an index shows that the utterances spoken by Pemeliant have a cause-effect relationship or contain a causal relationship with the signified. Third, the words in the speech in the form of symbols are the result of the agreement or convention of the Dayak Benuaq community.
The role of local government in the empowerment of MSME actors in Palopo City
Authors: Rahmayanti Alvira
Published: June 2024

The micro, small, and medium enterprise (MSME) activities cover almost all business fields, and the existence of MSMEs is crucial, especially for increasing income for low-income groups. This study aims to find out how the government carries out its role as a facilitator, as a regulator, and as a catalyst on the eight indicators based on the Regional Regulations of Palopo City, especially in the development of MSMEs in Palopo City. The research type is qualitative research, which explains events that actually occurred in the field during the study. Informants were heads of cooperatives and MSMEs, heads of the UMKM sector, staff of the cooperatives and MSMEs office of Palopo City, and several MSME business actors. Data collection was carried out through direct field observations, interviews, and documentation with informants. The findings indicate that the government's role in empowering MSMEs was carried out by the Office of Cooperatives and MSMEs, and the government carried out its role as a facilitator, a regulator, and a catalyst. The government has a major influence in carrying out the empowerment, and it can help MSME actors maintain and improve their business by providing access to financing and capital, promotion, coaching, mentoring training, and growing the business climate. Finally, we will look at the condition of MSMEs, especially micro-type businesses that have grown densely in various areas in Palopo City.
Analysis of local government supervision in surface mining: The case of Bulukumba Regency
Authors: Sam Aldiani Fitriayu , Arifin Indar , Syamsu Suhardiman
Published: June 2024

Supervision is the prevention or correction of errors, irregularities, discrepancies, and misappropriations that are not in accordance with the objectives of the predetermined authority. This study aims to determine how the form of local government supervision in supervising rock quarry mines in Bontotiro District, Bukukumba Regency. This study used a qualitative descriptive approach, and the data collection used observation, interviews, and documentation. Data was analyzed through the stages of data collection, data reduction, data presentation, and conclusions. This study shows how local government supervision of rock quarry mines in the study area is seen from two forms of supervision. First, preventive supervision was carried out before the implementation of mining activities through the supervision of exploration Mining Business Permits (IUP) for exploration implementation and Mining Business Permits (IUP) for production operations. Second, repressive supervision carried out during the implementation of mining activities refers to the supervision of Rock Excavation Production Operation Activities.
From Nazi Concentration Camp to Detention in Sweden 1945
Authors: Zetterström-Geschwind Britta
Published: June 2024

N/A
“Once Upon a Time”
Authors: Resløkken Åmund Norum , Henrichsen Gina Fraas , Ødemark John
Published: June 2024

N/A
“This is Home”
Authors: Hammarlin Mia-Marie
Published: June 2024

N/A
Biographical Notes
Authors: Ågotnes Hans Jakob , Arvidsson Alf , Fjell Tove Ingebjørg , Svensson Birgitta
Published: June 2024

Simon Ekström, Professor in Stockholm
Lotten Gustafsson Reinius, Professor in Stockholm
Markus Idvall, Professor in Stockholm
Ingun Grimstad Klepp, Professor at OsloMet
Proud Pictures
Authors: Liliequist Evelina
Published: June 2024

N/A
New Dissertations
Authors: Baklid Herleik , Idvall Markus , Rastas Anna , Blaakilde Anne Leonora , Stark Laura , Steel Tytti , Eade John , Schriewer Klaus , Tolgensbakk Ida
Published: June 2024

Stave Churches in the History of Knowledge, Sine Halkjelsvik Bjordal
Dis/ability in the Changing Welfare State, Christine Bylund
On the Challenges of Decoloniality in the Swedish Museum of Ethnography, Charlotte Engman
Listening to the Radio in Sweden, Elin Franzén
Women in Icelandic Folk Legends, Dagrún Ósk Jónsdóttir
Phenomenological Reflections on Seafarers’ Experiences from the Era of Steamships, Ulla Kallberg
Pilgrimage in Norway, Hannah Kristine Bjørke Lunde
Life-Modes in a Changing World Order, Niels Jul Nielsen
Affect in Online Hate Speech, Karin Sandell
The local and ethnic specifics of Yunnan in the work of modern Chinese artists: an "inside" and "outside" view
Authors: LAI FEI , Fedorovskaya Natal'ya Aleksandrovna
Published: June 2024

The article is devoted to the reflection of local and ethnic specifics (mainly Yunnan Province and the Tibetan borderland) in the works of Chinese artists of the Reform and Opening Up period – Jin Shangyi, Wang Yidong, Zhang Jian Jun, Yuan Yunsheng, Ai Xuan, Zeng Xiaofeng, Ma Yun, Mao Xuhui, Zhang Xiaogang, Liao Xinxue and Liu Ziming. Various cultural codes within which ethnic and local culture is interpreted in the paintings of visiting and local artists are identified. These differences in the perception and display of ethno-local specifics are especially evident when artists paint the same ethno-local object – for example, the life of Tibetan ethnic minorities. The glamorous characters of the Tibetan cycle of Zhang Jian Jun and Ai Xuan are strikingly different from the stern Tibetan women in the paintings of Zhang Xiaogang. The main conclusion of the study is that artists of various trends have their own ideological and aesthetic intentions, so they select individual figurative dominants from the whole variety of phenomena of tradition and everyday life of the ethnic group and build them into a new cultural code. It can be argued that the exotic cultural code (the view from the outside, characteristic mainly of visiting artists) presupposes “estrangement” and the dominance of aesthetic form to the detriment of ethno-cultural specifics, while the archaic code (the view from the inside) complements modern ethno-local elements with historical-cultural (folklore) examples. Artists of the esoteric type of coding possess “double vision”: they accurately reproduce the cultural landscape of Yunnan and the “life world” of ethnic minorities, but interpret it through individual optics, using world artistic experience.
Shared structure facilitates working memory of multiple sequences
Authors: Huang Qiaoli , Luo Huan
Published: June 2024

Daily experiences often involve the processing of multiple sequences, yet storing them challenges the limited capacity of working memory (WM). To achieve efficient memory storage, relational structures shared by sequences would be leveraged to reorganize and compress information. Here, participants memorized a sequence of items with different colors and spatial locations and later reproduced the full color and location sequences one after another. Crucially, we manipulated the consistency between location and color sequence trajectories. First, sequences with consistent trajectories demonstrate improved memory performance and a trajectory correlation between reproduced color and location sequences. Second, sequences with consistent trajectories show neural reactivation of common trajectories, and display spontaneous replay of color sequences when recalling locations. Finally, neural reactivation correlates with WM behavior. Our findings suggest that shared common structure is leveraged for storage of multiple sequences through compressed encoding and neural replay, together facilitating efficient information organization in WM.
Optogenetic silencing hippocampal inputs to the retrosplenial cortex causes a prolonged disruption of spatial working memory
Authors: Pinto-Correia Bárbara , Caldeira-Bernardo Patricia , Remondes Miguel
Published: June 2024

Working memory allows us to keep information in memory for the time needed to perform a given task. Such fundamental cognitive ability relies on a neural circuit including the retrosplenial cortex (RSC), connected to several cortical areas, functionally and anatomically, namely primary visual areas, and higher cognitive areas such as the cingulate, midcingulate, and subicular cortices. RSC bears intimate anatomical and functional connections with the hippocampus, and has been implicated in integrating and translating spatial-temporal contextual information between ego- and allocentric reference frames, to compute predictions about goals in goal-directed behaviors. The relative contribution of the hippocampus and retrosplenial cortex in working memory-guided behaviors remains unclear due to the lack of studies reversibly interfering with synapses connecting the two regions during such behaviors. We here used eArch3.0, a hyperpolarizing proton pump, to silence hippocampal axon terminals in RSC while animals perform a standard delayed non-match to place task. We found that such manipulation impairs memory retrieval, significantly decreasing performance and hastening decision-making. Furthermore, we found that such impairment outlasts light-activation of the opsin, its effects being noticed up to 3 subsequent trials.
Cytosolic S100A8/A9 promotes Ca2+ supply at LFA-1 adhesion clusters during neutrophil recruitment
Authors: Napoli Matteo , Immler Roland , Rohwedder Ina , Lupperger Valerio , Pfabe Johannes , Gonzalez Pisfil Mariano , Yevtushenko Anna , Vogl Thomas , Roth Johannes , Salvermoser Melanie , Dietzel Steffen , Slak Rupnik Marjan , Marr Carsten , Walzog Barbara , Sperandio Markus , Pruenster Monika
Published: June 2024

S100A8/A9 is an endogenous alarmin secreted by myeloid cells during many acute and chronic inflammatory disorders. Despite increasing evidence of the proinflammatory effects of extracellular S100A8/A9, little is known about its intracellular function. Here, we show that cytosolic S100A8/A9 is indispensable for neutrophil post-arrest modifications during outside-in signaling under flow conditions in vitro and neutrophil recruitment in vivo, independent of its extracellular functions. Mechanistically, genetic deletion of S100A9 in mice (

Mrp14
-/-

, functional

S100A8/A9
-/-

) caused dysregulated Ca
2+
signatures in activated neutrophils resulting in reduced Ca
2+
availability at the formed LFA-1/F-actin clusters with defective β
2
integrin outside-in signaling during post-arrest modifications. Consequently, we observed impaired cytoskeletal rearrangement, cell polarization and spreading, as well as cell protrusion formation in

Mrp14
-/-

compared to WT neutrophils, making

Mrp14
-/-

cells more susceptible to detach under flow, thereby preventing efficient neutrophil recruitment and extravasation into inflamed tissue.
One-sentence summary:
intracellular S100A8/A9 is indispensable for firm leukocyte adhesion under flow
The fascinating role of neuropeptide Bursicon and its receptor in shaping insect seasonal polyphenism
Authors: Zhang Zhixian , Li Jianying , Wang Yilin , Li Zhen , Liu Xiaoxia , Zhang Songdou
Published: June 2024

Seasonal polyphenism enables organisms to adapt to environmental challenges by increasing phenotypic diversity.
Cacopsylla chinensis
exhibits remarkable seasonal polyphenism, specifically in the form of summer-form and winter-form, which have distinct morphological phenotypes. Previous research has shown that low temperature and the temperature receptor
CcTRPM
regulate the transition from summer-form to winter-form in
C. chinensis
by impacting cuticle content and thickness. However, the underling neuroendocrine regulatory mechanism remains largely unknown. Bursicon, also known as the tanning hormone, is responsible for the hardening and darkening of the insect cuticle. In this study, we report for the first time on the novel function of Bursicon and its receptor in the transition from summer-form to winter-form in
C. chinensis
. Firstly, we identified
CcBurs-α
and
CcBurs-β
as two typical subunits of Bursicon in
C. chinensis
, which were regulated by low temperature (10°C) and
CcTRPM
. Subsequently,
CcBurs-α
and
CcBurs-β
formed a heterodimer that mediated the transition from summer-form to winter-form by influencing the cuticle chitin contents and cuticle thickness. Furthermore, we demonstrated that
CcBurs-R
acts as the Bursicon receptor and plays a critical role in the up-stream signaling of the chitin biosyntheis pathway, regulating the transition from summer-form to winter-form. Finally, we discovered that miR-6012 directly targets
CcBurs-R
, contributing to the regulation of Bursicon signaling in the seasonal polyphenism of
C. chinensis
. In summary, these findings reveal the novel function of neuroendocrine regulatory mechanism underlying seasonal polyphenism and provide critical insights into insect Bursicon and its receptor.
Contributions of mirror-image hair cell orientation to mouse otolith organ and zebrafish neuromast function
Authors: Ono Kazuya , Jarysta Amandine , Hughes Natasha , Jukic Alma , Chang Vanessa , Deans Michael R. , Eatock Ruth Anne , Cullen Kathleen , Kindt Katie , Tarchini Basile
Published: June 2024

Otolith organs in the inner ear and neuromasts in the fish lateral-line harbor two populations of hair cells oriented to detect stimuli in opposing directions. The underlying mechanism is highly conserved: the transcription factor EMX2 is regionally expressed in just one hair cell population and acts through the receptor GPR156 to reverse cell orientation relative to the other population. In mouse and zebrafish, loss of Emx2 results in sensory organs that harbor only one hair cell orientation and are not innervated properly. In zebrafish, Emx2 also confers hair cells with reduced mechanosensory properties. Here, we leverage mouse and zebrafish models lacking GPR156 to determine how detecting stimuli of opposing directions serves vestibular function, and whether GPR156 has other roles besides orienting hair cells. We find that otolith organs in
Gpr156
mouse mutants have normal zonal organization and normal type I-II hair cell distribution and mechano-electrical transduction properties. In contrast,
gpr156
zebrafish mutants lack the smaller mechanically-evoked signals that characterize Emx2-positive hair cells. Loss of GPR156 does not affect orientation-selectivity of afferents in mouse utricle or zebrafish neuromasts. Consistent with normal otolith organ anatomy and afferent selectivity,
Gpr156
mutant mice do not show overt vestibular dysfunction. Instead, performance on two tests that engage otolith organs is significantly altered – swimming and off-vertical-axis rotation. We conclude that GPR156 relays hair cell orientation and transduction information downstream of EMX2, but not selectivity for direction-specific afferents. These results clarify how molecular mechanisms that confer bi-directionality to sensory organs contribute to function, from single hair cell physiology to animal behavior.
Syngeneic natural killer cell therapy activates dendritic and T cells in metastatic lungs and effectively treat low-burden metastases
Authors: Huang Shih-Wen , Lai Yein-Gei , Liao Hao-Ting , Chang Chin-Ling , Ma Ruo-Yu , Chen Yung-Hsiang , Liou Yae-Huei , Wu Zhen-Qi , Wu Yu-Chen , Liu Ko-Jiunn , Huang Yen-Tsung , Yang Jen-Lung , Dai Ming-Shen , Liao Nan-Shih
Published: June 2024

Natural killer (NK) cells can control metastasis through cytotoxicity and IFN-γ production independently of T cells in experimental metastasis mouse models. The inverse correlation between NK activity and metastasis incidence supports a critical role for NK cells in human metastatic surveillance. However, autologous NK cell therapy has shown limited benefit in treating patients with metastatic solid tumors. Using a spontaneous metastasis mouse model of MHC-I
+
breast cancer, we found that transfer of IL-15/IL-12-conditioned syngeneic NK cells after primary tumor resection promoted long-term survival of mice with low metastatic burden and induced a tumor-specific protective T cell response that is essential for the therapeutic effect. Furthermore, NK cell transfer augments activation of conventional dendritic cells (cDCs), Foxp3
-
CD4
+
T cells and stem cell-like CD8
+
T cells in metastatic lungs, which requires IFN-γ of the transferred NK cells. These results imply direct interactions between transferred NK cells and endogenous cDCs to enhance T cell activation. We conducted an investigator-initiated clinical trial of autologous NK cell therapy in six patients with advanced cancer and observed that the NK cell therapy was safe and showed signs of effectiveness. These findings indicate that autologous NK cell therapy is effective in treating established low burden metastases of MHC-I
+
tumor cells by activating the cDC-T cell axis at metastatic sites.
A construção da concepção contemporânea de autor
Authors: Gomes Hamurabi Siqueira , Silva Gabriel Francisco da
Published: June 2024

Os sistemas de inteligência artificial (IA) têm se destacado no campo da produção artística, científica e literária, através da criação de imagens, músicas, roteiros de filmes, obras literárias e científicas etc. A esses sistemas tem-se denominado de inteligências artificiais generativas (IAG’s). Contudo, muito se tem discutido sobre a autoria das obras produzidas pelas IAG’s. Especula-se o alcance do conceito de autor e se tal definição pode ser estendida aos sistemas de IAG’s. Diante dessa problemática, o presente estudo tem como objetivo identificar os influxos que delimitaram a concepção contemporânea de autor e, a partir disso, verificar a sua possibilidade de transcendência para os sistemas de IAG’s. O trabalho foi desenvolvido através de um estudo exploratório e com abordagem qualitiva, mediante técnicas de pesquisa bibliográfica e documental com a análise das obras de Bittar (2019), Ascensão (2007), Barbosa (2010), Gonçalves (2019), Ferro (2019), Shcirru (2020), Linhares (2021), Faccenda (2021), Lins (2021), Moraes, (2022), Pires (2023) e da legislação aplicada ao tema. Foi analisada a evolução histórica do conceito de autor, bem como, seus elementos finalísticos de proteção. Percebeu-se que, durante os vários séculos de construção do conceito de autor, a proteção despendida pelas legislações mundo afora, ocupou-se de tratar o autor como figura humana, via de regra, e que essa concepção permanece, na contemporaneidade, fundamentando a legislação autoral pátria.
Comparison of LDL Levels Obtained by Martin-Hopkins Formula and Friedewald’s Formula with Directly Measured LDL: A Cross-sectional Study
Authors: Swapna GN , Indhumathi T
Published: June 2024

Introduction: Low Density Lipoprotein (LDL) is one of the major modifiable risk factor of atherosclerotic diseases and so a potential therapeutic target. So, Low Density Lipoprotein Cholesterol (LDL-C) is of primary importance to assess cardiac risk. Many formulae are used to calculate LDL-C. Friedewald’s formula, despite its limitations, has been widely used due to its simplicity and convenience. The present research was aimed to compare the accuracy of Friedewald’s formula with the Martin-Hopkins formula, providing valuable insights for clinical practice. Aim: To compare LDL levels obtained by the Martin-Hopkins and Friedewald’s formula with LDL levels obtained by directly measuring LDL in the southern India. Materials and Methods: The present hospital-based cross-sectional study was conducted in the Department of Biochemistry, Hassan Institute of Medical Sciences (HIMS), Hassan, Karnataka, India, from March 2023 to June 2023. Total participants were assessed for their serum lipid profile using standard methods. LDL-C was calculated using the Friedewald and Martin formulae, and these calculated values were then correlated with the directly measured LDL-C. Based on Triglyceride (TG) levels, subjects were divided into five groups to ensure a comprehensive analysis (Group-1: TG <100 mg/dL, Group-2: TG=101-150 mg/dL, Group-3: TG=151-200 mg/dL, Group-4: TG=201-400 mg/dL, Group-5: TG >400 mg/ dL). Groups were compared using a correlation analysis using Pearson’s correlation and paired t-test. Results: The study findings are significant. At TG levels <100 mg/dL, the Martin formula demonstrated a superior correlation (r=0.964, p-value≤0.001). At TG 101-150 mg/dL, 151-200 mg/ dL, and 201-400 mg/dL, Friedewald’s formula showed a slightly better correlation. However, at TG >400 mg/dL, Friedewald’s formula had a higher mean difference. ROC curves further confirmed the superiority of Martin’s formula (AUC=0.948, p-value≤0.001), demonstrating better diagnostic performance than Friedewald’s formula (AUC=0.947, p-value≤0.001) at all TG levels. Conclusion: The Martin-Hopkins formula showed better diagnostic performance among the two equations than the Friedewald’s formula. The mean difference was lesser for Martin’s formula than Friedewald’s formula at all TG levels except at levels <100 mg/dL. Considering the mean difference, Martin’s formula provided better LDL-C values than Friedewald’s formula for estimating LDL-C in the present study’s demographic population.
Influence of Simulated Erosion on Soil Properties and Maize Yield in the Southern Guinea Savanah Zone of Nigeria II
Authors: B.I. Agada , P.I. Agber , S. Idoga , F.D. Ugese
Published: June 2024

Aims: Long-term studies have been launched to assess the influence of artificial topsoil loss and its effects on soil properties and grain yield of cultivated maize.
Place and Duration of Study: The study was conducted during the 2016 to 2019 agricultural seasons at the Federal University of Agriculture in Makurdi, Nigeria.
Methodology: Three geo- referenced sites within the Federal University of Agriculture Makurdi, Nigeria namely: Site 1, Site_2 and Site_3 was used for the experiment. Erosion levels were established in June 2016 only by the incremental removal of topsoil at various depths.  The study of crop productivity using simulated erosion was carried out using Randomized Complete Block Design (RCBD) with desurfaced soil depths of 0cm (control), 5cm, 10cm, 15cm and 20cm as treatments. One profile pit was also dug in each of the three sites for soil characterization and soil type establishment. Data collected on soil physical and chemical properties as well as crop growth parameters and grain yield was subjected to Analysis of Variance (ANOVA) using R core Statistical Software.
Results: The study revealed that the soils of the three sites were classified as Kandic Paleustepts for Site_1, Typic Plinthustalfs for Site_2 and Typic Hapluderts for Site_3. These has brrn reported in drtail in paper I.  In comparison with the 0cm (control), maize grain yield was reduced by 7%, 89%, 100% and 100% at Site_1, 5%, 64%, 82% and 85% at Site_2 and 6%, 71%, 82% and 92% at Site_3 for the 5cm, 10cm, 15cm and 20cm topsoil depth removal respectively. The topsoil loss greatly lowered the grain yield of maize. We report the effects of topsoil loss on crop productivity for two years.
Investigating the Cardio-protective Activity of Agaricus bisporus in Wistar Rats Induced with Myocardial Infarction
Authors: Oladejo A.A. , Onwubuya E.I. , Kalu O. A. , Okeke C.B. , Okeke C.M. , Ikemefuna P.N.
Published: June 2024

Myocardial infarction is now recognized as one of the chronic diseases and the leading cause of death across the globe. The use of plants abundant in our environment, especially Agaricus bisporusprovides a cheap alternative to combat this common foe of mankind. Hence, this study was carried out to evaluate the cardio-protective effect of the leaf extract of Agaricus bisporus in isoproterenol-induced myocardial infarction. Fresh sample of Agaricus bisporus were purchased from a market at Asaba, Delta State, Nigeria. The samples were thereafter shredded with a knife and oven-dried at 40oC and pulverized and extracted, using Solvent-solvent (ethanol and water) (7:3) via maceration for 72 hr. The filtrate was evaporated to dryness to obtain the ethanol extract which was used for further bioassay study. The animals were administered with the extract of A. bisporus orally for fourteen consecutive days at a divided dose of 100 mg/kg, 200 mg/kg and 400 mg/kg body weights and thereafter 0.2 ml isoproterenol (ISO) at 150 mg/kg was injected intraperitoneally at an interval of 24 h on the 15th and 16th day. Subsequently, the blood pressures were monitored and blood collected for bioassay studies. Assay of High density lipoprotein cholesterol (HDL-c), low density lipoprotein cholesterol (LDL-c), triglyceride (TG) and total cholesterol (TC) levels as well as activities of lactate dehydrogenase (LDH), were carried out with standard assay kit sourced from Randox laboratories Ltd, United Kingdom with maximum adherence to the manufacturer’s instruction. Results showed a significant increase (P<0.05) in high density lipoproteins (HDL) levels and lactate dehydrogenase (LDH) activities with a significant decrease (P>0.05) in low density lipoproteins (LDL) and triglyceride  levels in a dose-dependent manner (100<200<400 mg/kg body weight) among the extract treated groups when compared to the untreated control group. Conversely, total  cholesterol levels of extract treated groups showed no significant difference when compared with the untreated control group.The findings of this work have shown that extract of Agaricus bisporus could help to mitigate cardiovascular diseases and could be used to produce plant based products to combat myocardial infarction, thereby improving general wellbeing.
Spray Drying of Fruits Juice Formulations of Ananas cosmosus L. and Balanites aegyptiaca: Antihyperglycemic Activity
Authors: Tsatsop Roli Karole Tsague , Tchienou Gertrude Djiobie , Talla Ernest Rodrigue , Chendjou Stive Martial Sikandi , Nguimbou Richard Marcel , Ngassoum Martin Benoît
Published: June 2024

Background: Balanites aegyptiaca is commonly used in folk medicine as antihyperglycemic agent.
Objective: Fruit juices from pineapple (Ananas cosmosus L), Balanites aegyptiaca and a blend after being encapsulated by spray dried with 10% maltodextrin, were examined for their physicochemical and antihyperglycemic properties.
Methods: Three different juice powders had been produced using spray dryer. The antihyperglycemic activity in glucose overloaded hyperglycemic rats has been evaluated.
Results: The juice powders had moisture contents ranging from 2.96 to 3.73% (dry basis). The fruit juice powders hygroscopicity varied between 14.44 and 15.38 g/100 g of juice powder samples. There were notable differences in the antihyperglycemic effects of the spray-dried juice samples on Wistar rats.  Blood sugar levels were significantly (P<0.05) lower in the Wistar rats batch administered with reconstituted Balanites juice and glibenclamide at T90min compared to the Normal control batch (4.77% and 29.44% respectively). Comparing the blood sugar levels of positive control (CP), Balanites, and Pineapple + Balanites animals to those of negative control (Cneg) animals and animals given pineapple juice, a substantial (P<0.05) decrease was noted.
Conclusion: The findings indicate that encapsulation by spray drying of pineapple juice with Balanites aegyptiaca fruits can be encouraged to be processed by fruit processing industries because the resulting juice powders have good antihyperglycemic properties.
Nipping and Foliar Spray for Enhanced Seed Yield in Horsegram var. Paiyur 2
Authors: Menaka C. , Prasath S. , Yuvaraja A. , Vanitha C. , Dharan T.
Published: June 2024

Horsegram (Macrotyloma uniflorum) is an underutilized food legume crop in the peninsular region and it belongs to the family Leguminaceae. The lower production and productivity of horsegram is due to its cultivation in rainfed areas of marginal and sub-marginal lands with poor management practices. Nutrients given as foliar spray is a unique technique to enhance plant growth by extending the availability of nutrients at all growth stages.  Exogenous application of PGR enhance the crop production by altering plant stand and quality. Hence, experiments were conducted by combining foliar nutrition with nipping to improve the seed yield and quality. Nipping in the company of foliar spray of brassinolide @1 ppm registered increased plant height, branches per plant, number of pods plant-1 and seed  yield plant-1 over control. The yield increases due to nipping on 40th DAS was 7% over control whereas foliar spray of brassinolide @ 1.0 ppm during flowering phase enhanced the yield upto 10% when compared to control. The plants subjected to nipping at 40 DAS combined with foliar spray of brassinolide @1.0 PPM increased the  seed yield up to 11% (779 kg/ha) over control (698kg/ha).
Enhancing Various Variety of Strawberry (Fragaria X ananassa) Yield with Seaweed Extract and Biochar under Prayagraj Agro Climatic Conditions
Authors: Kushwaha Akhilesh , Mishra Saket , Bahadur Vijay
Published: June 2024

The present investigation was carried out during 2021-22 and 2022-23 at Central Research Farm, Department of Horticulture, NAI, Sam Higginbottom University of Agriculture Technology and Sciences, Naini, Prayagraj was carried out with two factors having four of each in FRBD. The factors are Varieties (V1 - Winter Dawn, V2 - winter star, V3 - Sweet Charlie, V4 – Chandler) Organic Manures (M0 - No manures, M1 - Biochar 100 %, M2 - Seaweed extract 100%, M3 - Biochar + seaweed extract 50:50 %) which in combination makes 16 treatments. Among the treatments applied the combination of V1M3 (Winter Dawn + Biochar + Sea weed extract 50:50) was found to be best during 2021-22, 2022-23 and pooled data in terms of fruit set % with (8.17, 66.46 and 67.32 %), Number of fruit/plant (35.33, 32.40 and 33.87), Weight of fruit (36.36, 34.90 and 35.63 kg, Yield/plant (812.49, 791.14 and 801.81kg, Yield/plot (9.75, 9.49 and 9.62) kg, and yield/hectare (22.13, 21.51 and 21.82) ton.
Nutritional Advantages and Opportunities for Its Processing of Finger Millet (Eleusine coracana L.): A Comprehensive Review
Authors: Simran  , Chaudhary Sahil , Avinashe Harshal , Dubey Nidhi
Published: June 2024

Finger millet (Eleusine coracana L.) stands out as a highly nutritious yet underutilized grain among the millets. Despite its substantial health benefits, finger millet remains one of the least consumed foods globally. With the world's population growing at an unprecedented rate, addressing food security and malnutrition is a critical challenge. UNICEF reports indicate that nearly 2 billion people suffer from hidden hunger, and one in five children under five years old experience stunted growth due to malnutrition. Finger millet offers a promising solution to these issues due to its rich nutritional profile, which surpasses that of many common cereals. This review comprehensively examines the nutritional advantages of finger millet, highlighting its high content of calcium, iron, dietary fiber, and essential amino acids. Additionally, finger millet is a rich source of antioxidants and has a low glycemic index, making it beneficial for managing diabetes and other metabolic disorders. The review also explores various opportunities for processing finger millet to enhance its appeal and consumption. Processing techniques such as malting, fermentation, and extrusion can improve the bioavailability of nutrients and create diverse, palatable food products. By leveraging modern processing technologies, finger millet can be transformed into a staple food that addresses nutritional deficiencies and contributes to global food security. This review aims to underscore the importance of finger millet in combating malnutrition and promoting sustainable food systems. Increased awareness and research into finger millet's nutritional benefits and processing opportunities can pave the way for its broader adoption and integration into daily diets, ultimately contributing to better health outcomes worldwide.
Efficacy of Fungicides against Pathogenic Mycoflora of Soybean Seeds
Authors: Dhawan S. S. , Kadam A. M. , Kumbhar A.S.
Published: June 2024

Soybean (Glycine max L. Merrill.) crop is affected by number of pathogenic fungi, which are mostly seed borne, causing significant qualitative and quantitative losses. Therefore, present In vitro study was conducted to asses efficacy of fungicides against three major pathogenic seed borne fungi viz., Fusarium verticillioides, Macrophomina phaseolina and Alternaria alternata, by applying Poisoned Food Technique. Three separate experiments were planned and conducted with Completely Randomized Design (CRD) and all the treatments replicated thrice. The results revealed that all the seven seed dressing fungicides significantly inhibited mycelial growth of Fusarium verticillioides, Macrophomina phaseolina and Alternaria alternata, over untreated control. However, the fungicides viz., tebuconazole 25% WG and carbendazim 12% + mancozeb 63% 75 WP were found most effective with 100 per cent mycelial growth inhibition of Fusarium verticillioides and rest of the fungicides tested were comparatively less effective. However, mancozeb 75% WP, carboxin 37.5% + thiram 37.5% 75 WP and carbendazim 12% + mancozeb 63% 75 WP were found most effective with 100 per cent mycelial growth inhibition of Macrophomina phaseolina and rest of the fungicides tested were comparatively less effective. However, tebuconazole 25% WG and carboxin 37.5% + thiram 37.5% 75 WP were found most effective with 38.52 and 85.93%, respectively mycelial growth inhibition of Alternaria alternata and rest of the fungicides tested were comparatively less effective.
The Anatomical School of Padua
Authors: Porzionato Andrea , Macchi Veronica , Stecco Carla , Parenti Anna , De Caro Raffaele
Published: May 2012

The University of Padua is one of the most ancient in the world, being founded in 1222, and the most important anatomists of the XVI, XVII, and XVIII centuries studied and taught here. Probably, the first professor of anatomy and surgery was Bruno da Longobucco (c. 1200–c. 1286), who had previously studied at the Salerno School of Medicine. While professor in Padua, Andreas Vesalius (1514–1564) published De Humani Corporis Fabrica (1543), which is considered as the birth of the modern anatomy. Following professors were Realdo Colombo (c. 1516–1559), Gabriel Fallopius (1523–1562), Hieronymus Fabricius ab Aquapendente (1533–1619), Iulius Casserius (1552–1616), Johann Wesling (1598–1649), and Johann Georg Wirsung (1589–1643). Many other foreign scholars studied in the University of Padua, such as Thomas Linacre (c. 1460–1524), the founder of the Royal College of Physicians, Werner Rolfinck (1599–1673), and Olof Rudbeck (1630–1702), who created anatomical theatres in Germany and Sweden, respectively, on the basis of the Paduan model. The anatomy of the XVII century characteristically widened the scope of its enquiry to function, as in the Exercitatio Anatomica De Motu Cordis et Sanguinis in Animalibus (1628) by William Harvey (1578–1657). Further evolution was then given by the anatomy in the XVIII century, which tried to correlate alterations of structure with clinical symptoms. The most important anatomist of this century is Giovanni Battista Morgagni (1682–1771), whose masterpiece De Sedibus et Causis Morborum per Anatomen Indagatis (1761) is a landmark contribution that is viewed as the beginning of modern pathologic anatomy. This year falls the 300th anniversary of Morgagni's inaugural lecture on medical education, Nova Institutionum Medicarum Idea (1712), which is still relevant in its effort to stress the importance of a deep knowledge of all the preclinical and clinical aspects of medical science.