bluuebunny/crossref_metadata_2025 huggingface dataset:
Kidney involvement and histological findings in two pediatric COVID-19 patients
Authors: Serafinelli Jessica , Mastrangelo Antonio , Morello William , Cerioni Valeria Fanny , Salim Adib , Nebuloni Manuela , Montini Giovanni
Published: August 2021

Background

Histological findings of kidney involvement have been rarely reported in pediatric patients with SARS-CoV-2 infection. Here, we describe clinical, laboratory, and histological findings of two pediatric cases with almost exclusive kidney involvement by SARS-CoV-2.

Results

A 10-year-old girl with IgA vasculitis nephritis underwent kidney biopsy, showing diffuse and segmental mesangial-proliferative glomerulonephritis, and steroid therapy was initiated. After the worsening of the clinical picture, including an atypical skin rash, she was diagnosed with SARS-CoV-2. The re-evaluation of initial biopsy showed cytoplasmatic blebs and virus-like particles in tubular cells at electron microscopy. Despite SARS-CoV-2 clearance and the intensification of immunosuppression, no improvement was observed. A second kidney biopsy showed a crescentic glomerulonephritis with sclerosis, while virus-like particles were no longer evident.

The second patient was a 12-year-old girl with a 3-week history of weakness and weight loss. Rhinitis was reported the month before. No medications were being taken. Blood and urine analysis revealed elevated serum creatinine, hypouricemia, low molecular weight proteinuria, and glycosuria. A high SARS-CoV-2-IgG titre was detected. Kidney biopsy showed acute tubular-interstitial nephritis. Steroid therapy was started with a complete resolution of kidney involvement.

Conclusion

We can speculate that in both cases SARS-CoV-2 played a major role as inflammatory trigger of the kidney damage. Therefore, we suggest investigating the potential kidney damage by SARS-CoV-2 in children. Moreover, SARS-CoV-2 can be included among infectious agents responsible for pediatric acute tubular interstitial nephritis.
A survey on the user acceptance of PV battery storage systems
Authors: Fett Daniel , Dehler-Holland Joris , Schmutz Markus
Published: August 2021

This study presents the results of an analysis of user acceptance of PV battery storage systems. A structural equation model is developed based on Davis’ technology acceptance model (TAM). It is expanded by integrating elements of Ajzen’s theory of planned behavior (TPB). The main factors influencing the acceptance of PV battery storage systems are evaluated and analyzed. Empirical findings indicate that survey participants’ acceptance of PV battery storage systems is mainly influenced by their behavioral beliefs, perceived knowledge about battery storage systems, perceived ease of use, and perceived usefulness of PV battery storage systems. The results indicate a high degree of acceptance for PV battery storage systems.
Adjoint Complement to the Universal Momentum Law of the Wall
Authors: Kühl Niklas , Müller Peter M. , Rung Thomas
Published: August 2021

The paper is devoted to an adjoint complement to the universal Law of the Wall (LoW) for fluid dynamic momentum boundary layers. The latter typically follows from a strongly simplified, unidirectional shear flow under a constant stress assumption. We first derive the adjoint companion of the simplified momentum equation, while distinguishing between two strategies. Using mixing-length arguments, we demonstrate that the frozen turbulence strategy and a LoW-consistent (differentiated) approach provide virtually the same adjoint momentum equations, that differ only in a single scalar coefficient controlling the inclination in the logarithmic region. Moreover, it is seen that an adjoint LoW can be derived which resembles its primal counterpart in many aspects. The strategy is also compatible with wall-function assumptions for prominent RANS-type two-equation turbulence models, which ground on the mixing-length hypothesis. As a direct consequence of the frequently employed assumption that all primal flow properties algebraically scale with the friction velocity, it is demonstrated that a simple algebraic expression provides a consistent closure of the adjoint momentum equation in the logarithmic layer. This algebraic adjoint closure might also serve as an approximation for more general adjoint flow optimization studies using standard one- or two-equation Boussinesq-viscosity models for the primal flow. Results obtained from the suggested algebraic closure are verified against the primal/adjoint LoW formulations for both, low- and high-Re settings. Applications included in this paper refer to two- and three-dimensional shape optimizations of internal and external engineering flows. Related results indicate that the proposed adjoint algebraic turbulence closure accelerates the optimization process and provides improved optima at no computational surplus in comparison to the frozen turbulence approach.
Fragility estimation for global building classes using analysis of the Cambridge earthquake damage database (CEQID)
Authors: Spence Robin , Martínez-Cuevas Sandra , Baker Hannah
Published: August 2021

This paper describes CEQID, a database of earthquake damage and casualty data assembled since the 1980s based on post-earthquake damage surveys conducted by a range of research groups. Following 2017–2019 updates, the database contains damage data for more than five million individual buildings in over 1000 survey locations following 79 severely damaging earthquakes worldwide. The building damage data for five broadly defined masonry and reinforced concrete building classes has been assembled and a uniform set of six damage levels assigned. Using estimated peak ground acceleration (PGA) for each survey location based on USGS Shakemap data, a set of lognormal fragility curves has been developed to estimate the probability of exceedance of each damage level for each class, and separate fragility curves for each of five geographical regions are presented. A revised set of fragility curves has also been prepared in which the bias in the curve resulting from the uncertainty in the ground motion parameter has been removed. The uncertainty in the fragility curves is evaluated and discussed and the curves are compared with those from other studies. A resistance index for each class of building is developed and cross-regional comparisons using this resistance index are presented.
De novo centromere formation on chromosome fragments with an inactive centromere in maize (Zea mays)
Authors: Douglas Ryan N. , Yang Hua , Zhang Bing , Chen Chen , Han Fangpu , Cheng Jianlin , Birchler James A.
Published: August 2021

The B chromosome of maize undergoes nondisjunction at the second pollen mitosis as part of its accumulation mechanism. Previous work identified 9-Bic-1 (9-B inactivated centromere-1), which comprises an epigenetically silenced B chromosome centromere that was translocated to the short arm of chromosome 9(9S). This chromosome is stable in isolation, but when normal B chromosomes are added to the genotype, it will attempt to undergo nondisjunction during the second pollen mitosis and usually fractures the chromosome in 9S. These broken chromosomes allow a test of whether the inactive centromere is reactivated or whether a de novo centromere is formed elsewhere on the chromosome to allow recovery of fragments. Breakpoint determination on the B chromosome and chromosome 9 showed that mini chromosome B1104 has the same breakpoint as 9-Bic-1 in the B centromere region and includes a portion of 9S. CENH3 binding was found on the B centromere region and on 9S, suggesting both centromere reactivation and de novo centromere formation. Another mini chromosome, B496, showed evidence of rearrangement, but it also only showed evidence for a de novo centromere. Other mini chromosome fragments recovered were directly derived from the B chromosome with breakpoints concentrated near the centromeric knob region, which suggests that the B chromosome is broken at a low frequency due to the failure of the sister chromatids to separate at the second pollen mitosis. Our results indicate that both reactivation and de novo centromere formation could occur on fragments derived from the progenitor possessing an inactive centromere.
What do class comments tell us? An investigation of comment evolution and practices in Pharo Smalltalk
Authors: Rani Pooja , Panichella Sebastiano , Leuenberger Manuel , Ghafari Mohammad , Nierstrasz Oscar
Published: August 2021

Context

Previous studies have characterized code comments in various programming languages, showing how high quality of code comments is crucial to support program comprehension activities, and to improve the effectiveness of maintenance tasks. However, very few studies have focused on understanding developer practices to write comments. None of them has compared such developer practices to the standard comment guidelines to study the extent to which developers follow the guidelines.

Objective

Therefore, our goal is to investigate developer commenting practices and compare them to the comment guidelines.

Method

This paper reports the first empirical study investigating commenting practices in Pharo Smalltalk. First, we analyze class comment evolution over seven Pharo versions. Then, we quantitatively and qualitatively investigate the information types embedded in class comments. Finally, we study the adherence of developer commenting practices to the officialclass comment templateover Pharo versions.

Results

Our results show that there is a rapid increase in class comments in the initial three Pharo versions, while in subsequent versions developers added comments to both new and old classes, thus maintaining a similar code to comment ratio. We furthermore found three times as many information types in class comments as those suggested by the template. However, the information types suggested by the template tend to be present more often than other types of information. Additionally, we find that a substantial proportion of comments follow the writing style of the template in writing these information types, but they are written and formatted in a non-uniform way.

Conclusion

The results suggest the need to standardize the commenting guidelines for formatting the text, and to provide headers for the different information types to ensure a consistent style and to identify the information easily. Given the importance of high-quality code comments, we draw numerous implications for developers and researchers to improve the support for comment quality assessment tools.
Testing Children’s Mentalizing in Middle Childhood: Adopting the Child and Adolescent Reflective Functioning Scale with Clinical and Community Children
Authors: Bizzi Fabiola , Charpentier-Mora Simone , Cavanna Donatella , Borelli Jessica L. , Ensink Karin
Published: August 2021

Beginning with Ensink’s seminal study (2015), the field entered a new era in which we were able to measure mentalizing in school-aged children. The goal of this work is to continue developing the state of the research within this tradition by exploring the psychometric properties of the Child Reflective Functioning Scale (CRFS) - a measure applied to the Child Attachment Interview and designed to assess RF during middle childhood - within both clinical and normative groups, and to examine if it differentiates between both groups. Participants were 159 Italian children (age range 8–12 years, Mage = 10.66, SD =1.83; 57% males) divided into two groups: 71 children with emotional-behavioral problems (‘clinical group’) and 88 children without emotional-behavioral problems (‘community group’). Demographic data and Verbal Comprehension Index were collected. A two-factor model of CRFS (self- and other-focused RF) was confirmed in both groups, revealing that these intrapersonal and interpersonal indicators of children’s RF are important domains of mentalizing abilities in middle childhood. The results revealed adequate inter-rater reliability of the CRFS. Controlling for the effect of potentially confounding demographic variables, significant differences on CRFS scales between clinical and community groups were found. The clinical group showed lower levels of CRFS scores than normative group, but importantly, the self-focused RF score uniquely predicted clinical/community status. Taken together, the findings showed that the CRFS is a reliable and validity measure for assessing RF in middle childhood with clinical and normative groups, contributing important information to the scientific literature on mentalizing in middle childhood.
Influence of bovine serum albumin on corrosion behaviour of pure Zn in phosphate buffered saline
Authors: Liu Lijun , Lu Lili , Zhang Hai-Jun , Wang Lu-Ning
Published: August 2021

Zinc (Zn) and its alloys have received increasing attention as new alternative biodegradable metals. However, consensus has not been reached on the corrosion behaviour of Zn. As cardiovascular artery stent material, Zn is supposed to contact with plasma that contains inorganic salts and organic components. Protein is one of the most important constitute in the plasma and could adsorb on the material surface. In this paper, bovine serum albumin (BSA) was used as a typical protein. Influences of BSA on pure Zn corrosion in phosphate buffered saline is investigated as a function of BSA concentrations and immersion durations by electrochemical techniques and surface analysis. Results showed that pure Zn corrosion was progressively accelerated with BSA concentrations (ranging from 0.05 to 5 g L−1) at 0.5 h. With time evolves, formation of phosphates as corrosion product was delayed by BSA adsorption, especially at concentration of 2 g L−1. Within 48 h, the corrosion of pure Zn was alleviated by BSA at concentration of 0.1 g L−1, whereas the corrosion was enhanced after 168 h. Addition of 2 g L−1 BSA has opposite influence on the pure Zn corrosion. Furthermore, schematic corrosion behaviour at protein/Zn interfaces was proposed. This work encourages us to think more about the influence of protein on the material corrosion and helps us to better understand the corrosion behaviour of pure Zn.
Improved cytocompatibility and antibacterial properties of zinc-substituted brushite bone cement based on β-tricalcium phosphate
Authors: Fadeeva Inna V. , Goldberg Margarita A. , Preobrazhensky Ilya I. , Mamin Georgy V. , Davidova Galina A. , Agafonova Nadezhda V. , Fosca Marco , Russo Fabrizio , Barinov Sergey M. , Cavalu Simona , Rau Julietta V.
Published: August 2021

For bone replacement materials, osteoconductive, osteoinductive, and osteogenic properties are desired. The bacterial resistance and the need for new antibacterial strategies stand among the most challenging tasks of the modern medicine. In this work, brushite cements based on powders of Zinc (Zn) (1.4 wt%) substituted tricalcium phosphate (β-TCP) and non-substituted β-TCP were prepared and investigated. Their initial and final phase composition, time of setting, morphology, pH evolution, and compressive strength are reported. After soaking for 60 days in physiological solution, the cements transformed into a mixture of brushite and hydroxyapatite. Antibacterial activity of the cements against Enterococcus faecium, Escherichia coli, and Pseudomonas aeruginosa bacteria strains was attested. The absence of cytotoxicity of cements was proved for murine fibroblast NCTC L929 cells. Moreover, the cell viability on the β-TCP cement containing Zn2+ ions was 10% higher compared to the β-TCP cement without zinc. The developed cements are perspective for applications in orthopedics and traumatology.
Fabrication and characterization of microstructure-controllable COL-HA-PVA hydrogels for cartilage repair
Authors: Xie Jie , Wang Wu , Zhao Ruibo , Lu Wei , chen Liang , Su Weiping , Zeng Min , Hu Yihe
Published: August 2021

Polyvinyl alcohol (PVA) hydrogel has gained interest in cartilage repair because of its highly swollen, porosity, and viscoelastic properties. However, PVA has some deficiencies, such as its poor biocompatibility and microstructure. This research aimed to design novel hydroxyapatite (HA)-collagen (COL)-PVA hydrogels. COL was added to improve cell biocompatibility, and the microstructure of the hydrogels was controlled by fused deposition modeling (FDM). The feasibility of the COL-HA-PVA hydrogels in cartilage repair was evaluated by in vitro and in vivo experiments. The scanning electron microscopy results showed that the hybrid hydrogels had interconnected macropore structures that contained a COL reticular scaffold. The diameter of the macropore was 1.08–1.85 mm, which corresponds to the diameter of the denatured PVA column. The chondrocytes were then seeded in hydrogels to assess the cell viability and formation of the cartilage matrix. The in vitro results revealed excellent cellular biocompatibility. Osteochondral defects (8 mm in diameter and 8 mm in depth) were created in the femoral trochlear of goats, and the defects were implanted with cell-seeded hydrogels, cell-free hydrogels, or a blank control. The in vivo results showed that the COL-HA-PVA hydrogels effectively repaired cartilage defects, especially the conditions inoculated with chondrocyte in advance. This research suggests that the COL-HA-PVA hydrogels have promising application in cartilage repair.
Biosafety of mesoporous silica nanoparticles: a combined experimental and literature study
Authors: Sun Lue , Sogo Yu , Wang Xiupeng , Ito Atsuo
Published: August 2021

Mesoporous silica (MS) particles have been explored for various healthcare applications, but universal data about their safety and/or toxicity are yet to be well-established for clinical purposes. Information about general toxicity of hollow MS (HMS) particles and about immunotoxicity of MS particles are significantly lacked. Therefore, acute toxicity and immunotoxicity of HMS particles were experimentally evaluated. A systematic and objective literature study was parallelly performed to analyze the published in vivo toxicity of MS particles. Lethal acute toxicity of MS particles is likely to arise from their physical action after intravenous and intraperitoneal administrations, and only rarely observed after subcutaneous administration. No clear relationship was identified between physicochemical properties of MS particles and lethality as well as maximum tolerated dose with some exceptions. At sub-lethal doses, MS particles tend to accumulate mainly in lung, liver, and spleen. The HMS particles showed lower inflammation-inducing ability than polyinosinic-polycytidylic acid and almost the same allergy-inducing ability as Alum. Finally, the universal lowest observed adverse effect levels were determined as 0.45, 0.81, and 4.1 mg/kg (human equivalent dose) for intravenous, intraperitoneal, and subcutaneous administration of MS particles, respectively. These results could be helpful for determining an appropriate MS particle dose in clinical study.
Effects of actuation of nanoporous gold on cell orientation in a fibroblast sheet
Authors: Wu Peizheng , Sawaki Shogo , Hakamada Masataka , Mabuchi Mamoru
Published: August 2021

Mechanical stimulation such as flood flow often plays a vital role in the growth and maintenance of a living body, and it is important to investigate cell responses to mechanical stimulation. To date, cell responses to mechanical stimulation have been investigated in detail. However, the cell responses have been little known in a cell sheet. In the present study, a small cyclic strain (CS) of ~0.5% generated by a nanoporous gold actuator was loaded on a cell sheet of fibroblasts, and the effects of the CS on cell orientation were investigated. Individual cells were randomly distributed after the CS application, whereas cells were oriented in a specific direction after the CS application for the cell sheet. Thus, the CS had a different effect on the cell sheet from that on the individual cells. It is suggested that the cadherin/p-120 catenin complex played an important role in the cell response to mechanical stimulation in a cell sheet.
Divergent Molecular and Physiological Response of Two Maize Breeding Lines Under Phosphate Deficiency
Authors: Sun Yanling , Zheng Hongxia
Published: August 2021

Inorganic phosphate (Pi) deficiency is a main limiting factor on crops growth and to select low-Pi tolerant breeding lines is very significant for crop breeding. Here, two contrasting maize (Zea maysL.) breeding lines showed different physiological response to Pi deficiency. The low-Pi tolerant QXN233 maintained normal growth, including high fresh weight, green leaves, strong shoots, and numerous roots relative to that of the sensitive MH05-4, mainly due to QXN233’ high Pi content in shoots under Pi deficiency. Importantly, some Pi-responsive genes were detected, and among them, Pi transportersZmPHT1;1andZmPHT1;9as well as phytase geneZmphytase 2were expressed increasingly in QXN233 compared to MH05-4 under Pi deprivation or Pi resupply. Moreover, QXN233 had higher proline content, soluble sugar content, and SOD activity than MH05-4, related with its tolerance. Taken together, this study enriches the understanding of the mechanism of maize responding to Pi deficiency.
Clinical trial registries as Scientometric data: A novel solution for linking and deduplicating clinical trials from multiple registries
Authors: Thiele Christian , Hirschfeld Gerrit , von Brachel Ruth
Published: August 2021

Registries of clinical trials are a potential source for scientometric analysis of medical research and serve important functions for the research community and the public at large. Clinical trials that recruit patients in Germany are usually registered in the German Clinical Trials Register (DRKS) or in international registries such as ClinicalTrials.gov. Furthermore, the International Clinical Trials Registry Platform (ICTRP) aggregates trials from multiple primary registries. We queried the DRKS, ClinicalTrials.gov, and the ICTRP for trials with a recruiting location in Germany. Trials that were registered in multiple registries were linked using the primary and secondary identifiers and a Random Forest model based on various similarity metrics. We identified 35,912 trials that were conducted in Germany. The majority of the trials was registered in multiple databases. 32,106 trials were linked using primary IDs, 26 were linked using a Random Forest model, and 10,537 internal duplicates on ICTRP were identified using the Random Forest model after finding pairs with matching primary or secondary IDs. In cross-validation, the Random Forest increased the F1-score from 96.4% to 97.1% compared to a linkage based solely on secondary IDs on a manually labelled data set. 28% of all trials were registered in the German DRKS. 54% of the trials on ClinicalTrials.gov, 43% of the trials on the DRKS and 56% of the trials on the ICTRP were pre-registered. The ratio of pre-registered studies and the ratio of studies that are registered in the DRKS increased over time.
Leveraging full-text article exploration for citation analysis
Authors: La Quatra Moreno , Cagliero Luca , Baralis Elena
Published: August 2021

Scientific articles often include in-text citations quoting from external sources. When the cited source is an article, the citation context can be analyzed by exploring the article full-text. To quickly access the key information, researchers are often interested in identifying the sections of the cited article that are most pertinent to the text surrounding the citation in the citing article. This paper first performs a data-driven analysis of the correlation between the textual content of the sections of the cited article and the text snippet where the citation is placed. The results of the correlation analysis show that the title and abstract of the cited article are likely to include content highly similar to the citing snippet. However, the subsequent sections of the paper often include cited text snippets as well. Hence, there is a need to understand the extent to which an exploration of the full-text of the cited article would be beneficial to gain insights into the citing snippet, considering also the fact that the full-text access could be restricted. To this end, we then propose a classification approach to automatically predicting whether the cited snippets in the full-text of the paper contain a significant amount of new content beyond abstract and title. The proposed approach could support researchers in leveraging full-text article exploration for citation analysis. The experiments conducted on real scientific articles show promising results: the classifier has a 90% chance to correctly distinguish between the full-text exploration and only title and abstract cases.
Analysis of scientific collaboration network of Italian Institute of Technology
Authors: di Bella Enrico , Gandullia Luca , Preti Sara
Published: August 2021

It has been proven that collaboration between authors leads to a positive influence on research. This paper aims to analyse the complex structure of the co-authorship network among researchers of the Italian Institute of Technology. In this paper, we examine two different co-authorship networks created starting from the data of the papers published by the Italian Institute of Technology during the period 2006–2019. We apply the main Social Network Analysis techniques to describe the relational structure of the group of researchers and its evolution over time. The structure and characteristics of the networks are analysed both at macro and micro levels, and an attempt is made to identify a possible relationship between the position of researchers in the graphs and their scientific productivity and quality.
A big picture: bibliometric study of academic publications from post-Soviet countries
Authors: Chankseliani Maia , Lovakov Andrey , Pislyakov Vladimir
Published: August 2021

The world’s largest community of scientists disintegrated following the dissolution of the Soviet Union. With extremely scarce resources and limited academic freedom as starting points, researchers in this region have been creating new knowledge; they have been building on rich scientific traditions in selected disciplines and, at times, paving new paths in non-traditional disciplines. At present, the cumulative contribution of post-Soviet countries to global research output is only three percent, indicating that these countries are not key players on the global research scene. This study uses bibliometric methods to offer novel empirical insight into the quantity and impact of academic publications; it also looks at the quality of journals in which the output is published. The findings reveal that fifteen post-Soviet countries differ considerably in terms of how much they have prioritised research, as well as the quantity, quality, and impact of their publications. The research productivity across the region has not been high and, taken together, these countries have produced publications of considerably lower quality and lower impact when viewed in the context of global research output. At the same time, researchers from post-Soviet countries tap into international collaborative networks actively, resulting in an exceptionally large proportion of publications from this region being internationally co-authored. In the historical context of Soviet research being known as one of the least collaborative globally, this finding indicates that researchers in the region are attractive to international collaborators and may be seeking such partnerships due to relatively modest research capacity at home.
Scaling Features of Diurnal Variation of Galactic Cosmic Rays
Authors: Modzelewska Renata , Krasińska Agata , Wawrzaszek Anna , Gil Agnieszka
Published: August 2021

We analyze the scaling properties of the diurnal variation of galactic cosmic rays (GCRs) in Solar Cycle 24 and the solar minima between Solar Cycles 23/24 and 24/25 for 2007 – 2019 based on the count rates of the Oulu, Newark, Hermanus, and Potchefstroom neutron monitors. The scaling features of the GCR diurnal variation are studied by evaluating the Hurst exponent, a quantitative parameter used as an indicator of the state of the randomness of a time series. We estimate the Hurst exponents for GCR diurnal-variation parameters amplitude and phase using structure-function and detrended-fluctuation-analysis methods. Results show that the Hurst exponents for the GCR diurnal variation vary in the range from $\approx0.3$
≈
0.3
to $\approx0.9$
≈
0.9
, with a general tendency of being systematically above 0.5. It suggests that the GCR diurnal variation reveals a more persistent structure than Brownian motion. However, the time series of GCR diurnal-variation amplitude and phase evolve from a more persistent structure in the solar minimum between Solar Cycles 23/24 in 2007 – 2009 to a more random character in and near the solar maximum 2012 – 2014. This observation seems to be in agreement with the general configuration of the heliosphere through the 11-year solar-activity cycle. Moreover, the temporal profile of the Hurst exponent for GCR diurnal amplitude and phase around the beginning of the solar minimum between Solar Cycles 24/25 (2018 – 2019) differs from the solar minimum between Solar Cycles 23/24 in 2007 – 2009, suggesting a dependence on solar-magnetic polarity. These findings could shed more light on GCR particle transport in the turbulent heliosphere over the solar cycle.
Decayless Kink Oscillations Excited by Random Driving: Motion in Transitional Layer
Authors: Ruderman M. S. , Petrukhin N. S. , Pelinovsky E.
Published: August 2021

In this article we study the plasma motion in the transitional layer of a coronal loop randomly driven at one of its footpoints in the thin-tube and thin-boundary-layer (TTTB) approximation. We introduce the average of the square of a random function with respect to time. This average can be considered as the square of the oscillation amplitude of this quantity. Then we calculate the oscillation amplitudes of the radial and azimuthal plasma displacement as well as the perturbation of the magnetic pressure. We find that the amplitudes of the plasma radial displacement and the magnetic-pressure perturbation do not change across the transitional layer. The amplitude of the plasma radial displacement is of the same order as the driver amplitude. The amplitude of the magnetic-pressure perturbation is of the order of the driver amplitude times the ratio of the loop radius to the loop length squared. The amplitude of the plasma azimuthal displacement is of the order of the driver amplitude times $\text{Re}^{1/6}$

Re

1
/
6

, where Re is the Reynolds number. It has a peak at the position in the transitional layer where the local Alfvén frequency coincides with the fundamental frequency of the loop kink oscillation. The ratio of the amplitude near this position and far from it is of the order of $\ell$
ℓ
, where $\ell$
ℓ
is the ratio of thickness of the transitional layer to the loop radius. We calculate the dependence of the plasma azimuthal displacement on the radial distance in the transitional layer in a particular case where the density profile in this layer is linear.
Commitment engineering: conceptual engineering without representations
Authors: Löhr Guido
Published: August 2021

It is largely assumed that conceptual engineering is essentially about revising, introducing, or eliminating representational devices, in particular the intension and extension of words and concepts. However, tying conceptual engineering too closely to representations is risky. Not everyone endorses the notion of representation as theoretically helpful or even real. Not everyone thinks that concepts or meanings should be understood in terms of the notion of representation. Does this mean that conceptual engineering is not interesting or relevant for these skeptics? In this paper, I motivate and propose a non-representationalist construal of conceptual engineering. I argue that conceptual engineers can be understood as primarily engineering linguistic entitlements and commitments rather than representational devices. Note that this account is non-representationalist, but explicitly not anti-representationalist. Representations may play a significant role when it comes to justifying and completing commitment engineering projects.
Brentano and the Medieval Distinction Between First and Second Intentions
Authors: Taieb Hamid
Published: August 2021

Brentano’s account of intentionality has often been traced back to its scholastic sources. This is justified by his claim that objects of thought have a specific mode of being—namely, “intentional inexistence” (intentionale Inexistenz)—and that mental acts have an “intentional relation” (intentionale Beziehung) to these objects. These technical terms in Brentano do indeed recall the medieval notions ofesse intentionale, which is a mode of being, and ofintentio, which is a “tending towards” (tendere in) of mental acts. However, within the lexical family ofintentiothere is another distinction that plays an important role in medieval philosophy—namely, the distinction between first and second intentions (intentio primaandintentio secunda), which are, roughly speaking, concepts of things and concepts of concepts respectively. What is less well-known is that Brentano explicitly borrowed this distinction as well, and used it in his account of intentionality. This paper explores this little-known chapter in the scholastic-Austrian history of intentionality by evaluating both the historical accuracy and the philosophical significance of Brentano’s borrowing of the scholastic distinction between first and second intentions.
Recommendations for marathon runners: on the application of recommender systems and machine learning to support recreational marathon runners
Authors: Smyth Barry , Lawlor Aonghus , Berndsen Jakim , Feely Ciara
Published: August 2021

Every year millions of people, from all walks of life, spend months training to run a traditional marathon. For some it is about becoming fit enough to complete the gruelling 26.2 mile (42.2 km) distance. For others, it is about improving their fitness, to achieve a new personal-best finish-time. In this paper, we argue that the complexities of training for a marathon, combined with the availability of real-time activity data, provide a unique and worthwhile opportunity for machine learning and for recommender systems techniques to support runners as they train, race, and recover. We present a number of case studies—a mix of original research plus some recent results—to highlight what can be achieved using the type of activity data that is routinely collected by the current generation of mobile fitness apps, smart watches, and wearable sensors.
Formalin-casein enhances water absorbency of calcium alginate beads and activity of encapsulated Metarhizium brunneum and Saccharomyces cerevisiae
Authors: Hermann Katharina M. , Grünberger Alexander , Patel Anant V.
Published: August 2021

The control of root-feeding wireworms has become more challenging as synthetic soil insecticides have been progressively phased out due to environmental risk concerns. Innovative microbial control alternatives such as the so-called attract-and-kill strategy depend on the rapid and successful development of dried encapsulated microorganisms, which is initiated by rehydration. Casein is a functional additive that is already used in food or pharmaceutical industry due to its water binding capacity. Cross-linked forms such as formalin-casein (FC), exhibit altered network structures. To determine whether FC influences the rehydration of alginate beads in order to increase the efficacy of an attract-and-kill formulation for wireworm pest control, we incorporated either casein or FC in different alginate/starch formulations. We investigated the porous properties of alginate/starch beads and subsequently evaluated the activities of the encapsulated entomopathogenic fungus Metarhizium brunneum and the CO2 producing yeast Saccharomyces cerevisiae. Adding caseins altered the porous structure of beads. FC decreased the bead density from (1.0197 ± 0.0008) g/mL to (1.0144 ± 0.0008) g/mL and the pore diameter by 31%. In contrast to casein, FC enhanced the water absorbency of alginate/starch beads by 40%. Furthermore, incorporating FC quadrupled the spore density on beads containing M. brunneum and S. cerevisiae, and simultaneous venting increased the spore density even by a factor of 18. Moreover, FC increased the total CO2 produced by M. brunneum and S. cerevisiae by 29%. Thus, our findings suggest that rehydration is enhanced by larger capillaries, resulting in an increased water absorption capacity. Our data further suggest that gas exchange is improved by FC. Therefore, our results indicate that FC enhances the fungal activity of both fungi M. brunneum and S. cerevisiae, presumably leading to an enhanced attract-and-kill efficacy for pest control.

Graphic abstract
Analysis of oxidative stress indicators in Polish patients with prostate cancer
Authors: Drozdz-Afelt Joanna Maria , Koim-Puchowska Beata Barbara , Kaminski Piotr
Published: August 2021

The aim of the study was to analyze the activity of antioxidant enzymes (glutathione S-transferase, catalase, superoxide dismutase) and the concentration of malondialdehyde in order to determine the role of detoxification mechanisms in prostate cancer. The activities of superoxide dismutase (SOD), catalase (CAT), and glutathione S-transferase (GST) were measured using ready-made kits; lipid peroxidation intensity was determined by the thiobarbituric acid method. Superoxide dismutase was the only enzyme among antioxidant and detoxification enzymes for which a statistically significant difference in activity was found between the studied groups (1.4 U·ml−1 in patients vs. 1.6 U·ml−1 in control). No statistically significant differences were found for GST, CAT or the concentration of MDA between the group of men with prostate cancer and the control group. The lower SOD activity in men with prostate cancer may be due to a deficiency in their antioxidant defense system.
A Scoping Review of Professional Identity Formation in Undergraduate Medical Education
Authors: Sarraf-Yazdi Shiva , Teo Yao Neng , How Ashley Ern Hui , Teo Yao Hao , Goh Sherill , Kow Cheryl Shumin , Lam Wei Yi , Wong Ruth Si Man , Ghazali Haziratul Zakirah Binte , Lauw Sarah-Kei , Tan Javier Rui Ming , Lee Ryan Bing Qian , Ong Yun Ting , Chan Natalie Pei Xin , Cheong Clarissa Wei Shuen , Kamal Nur Haidah Ahmad , Lee Alexia Sze Inn , Tan Lorraine Hui En , Chin Annelissa Mien Chew , Chiam Min , Krishna Lalit Kumar Radha
Published: August 2021

Background

Professional identity formation (PIF) in medical students is a multifactorial phenomenon, shaped by ways that clinical and non-clinical experiences, expectations and environmental factors merge with individual values, beliefs and obligations. The relationship between students’ evolving professional identity and self-identity or personhood remains ill-defined, making it challenging for medical schools to support PIF systematically and strategically. Primarily, to capture prevailing literature on PIF in medical school education, and secondarily, to ascertain how PIF influences on medical students may be viewed through the lens of the ring theory of personhood (RToP) and to identify ways that medical schools support PIF.

Methods

A systematic scoping review was conducted using the systematic evidence-based approach. Articles published between 1 January 2000 and 1 July 2020 related to PIF in medical students were searched using PubMed, Embase, PsycINFO, ERIC and Scopus. Articles of all study designs (quantitative and qualitative), published or translated into English, were included. Concurrent thematic and directed content analyses were used to evaluate the data.

Results

A total of 10443 abstracts were identified, 272 full-text articles evaluated, and 76 articles included. Thematic and directed content analyses revealed similar themes and categories as follows: characteristics of PIF in relation to professionalism, role of socialization in PIF, PIF enablers and barriers, and medical school approaches to supporting PIF.

Discussion

PIF involves iterative construction, deconstruction and inculcation of professional beliefs, values and behaviours into a pre-existent identity. Through the lens of RToP, factors were elucidated that promote or hinder students’ identity development on individual, relational or societal levels. If inadequately or inappropriately supported, enabling factors become barriers to PIF. Medical schools employ an all-encompassing approach to support PIF, illuminating the need for distinct and deliberate longitudinal monitoring and mentoring to foster students’ balanced integration of personal and professional identities over time.
Photocatalytic Activity Enhancement of Low-pressure Cold-Sprayed TiO2 Coatings Induced by Long-term Water Vapor Exposure
Authors: Seremak Wioletta , Baszczuk Agnieszka , Jasiorski Marek , Gibas Anna , Winnicki Marcin
Published: August 2021

This work shows that the titanium dioxide coatings obtained by low-pressure cold gas spraying with the use of the sol–gel amorphous TiO2 powder are characterized by photocatalytic activity despite their partial amorphous content. Moreover, the research outcome suggests that the decomposition rate of organic pollutants is enhanced after long-term exposure to moisture. The condensation humidity test is not detrimental to the continuity and integrity of the coating, but the phase composition of coatings changes—with the exposure to water vapor, the portion of the amorphous phase crystallizes into brookite. The mechanism responsible for the conversion of amorphous TiO2 into brookite is attributed to the water-driven dissolution and reprecipitation of TiO6 octahedra. It has been shown that an additional parameter necessary for the stabilization of the brookite is the oxygen depletion of the amorphous structure of titanium dioxide. Considering the results presented in this paper and the advantages of a portable, low-pressure cold spray system for industrial applications, it is expected that TiO2 coatings produced from a sol–gel feedstock powder can be further developed and tested as efficient photocatalysts.
Evaluation of geohazards in the Cape Girardeau area using LiDAR and GIS, Southeast Missouri, USA
Authors: Ilesanmi Olufeyisayo B. , Rogers J. David , Oboh-Ikuenobe Francisca E.
Published: August 2021

The New Madrid Seismic Zone (NMSZ) has historically recorded some of the largest intensity earthquakes in North America, including significant earth movements that resulted in about 2000 felt earthquakes during 1811–1812. The region continues to experience mass wasting due to earth movements. The aim of this study is to understand the influence of geologic variables on mass wasting processes in the greater Cape Girardeau area, which forms the commercial center of Missouri's fertile "Bootheel" region. Earth movement susceptibility was evaluated in Cape Girardeau and Bollinger counties and portions of Stoddard and Scott counties by mapping potential landslide features on topographic maps, field verification of such features, and geospatial analysis of recent LiDAR imagery. In order to evaluate the changes in surface morphology, slope inclination, hillshade aspect, hydrology, lithology, faults, precipitation, seismicity, sinkholes, and geohydrology were considered. Geographically weighted analysis of the geomorphologic variables identified zones of relative risk. In addition, data were evaluated for oil and gas pipelines, bridges, utilities, and open pit mines associated with mass wasting on public and economic infrastructure. The results suggest that anthropogenic changes commonly associated with urban development impact land use, runoff, infiltration, and slope failures, while sustained precipitation and seismic ground shaking tend to trigger landslides. The scale of mass wasting in the study area was robust, varying from as small as one-half hectare to as much as 67 km2. The vulnerability of the population in susceptible areas tends to increase at the lower elevations and on alluvial flood plains. Thus, hazard susceptibility evaluation can be useful in both community planning as well as emergency preparedness.
Classification of advanced methods for evaluating neurotoxicity
Authors: Han Kyung-Seok , Woo Dong Ho
Published: August 2021

Purpose of review

As fields such as neurotoxicity evaluation and neuro-related drug research are increasing in popularity, there is a demand for the expansion of neurotoxicity research. Currently, neurotoxicity is assessed by measuring changes in weight and behavior. However, measurement of such changes does not allow the detection of subtle and inconspicuous neurotoxicity. In this review, methods for advancing neurotoxicity research are divided into molecule-, cell-, circuit-, and animal model-based methods, and the results of previous studies assessing neurotoxicity are provided and discussed.

Recent findings

In coming decades, cooperation between universities, national research institutes, industrial research institutes, governments, and the private sector will become necessary when identifying alternative methods for neurotoxicity evaluation, which is a current goal related to improving neurotoxicity assessment and an appropriate approach to neurotoxicity prediction. Many methods for measuring neurotoxicity in the field of neuroscience have recently been reported. This paper classifies the supplementary and complementary experimental measures for evaluating neurotoxicity.
Pooled retrospective analysis of 70 mg erenumab in episodic and chronic migraine: a two tertiary headache centers experience during clinical practice
Authors: Storch P. , Burow P. , Möller B. , Kraya T. , Heintz S. , Politz N. , Naegel S.
Published: August 2021

Erenumab is a monoclonal antibody, targeted against the calcitonin gene-related peptide (CGRP) receptor. Clinical studies have demonstrated prophylactic efficacy in both episodic (EM) and chronic migraine (CM). The aim of the present study is to evaluate the efficacy of treatment in tertiary headache centers under real-life conditions. In a retrospective analysis, the period of 3 months before and after initiation of erenumab therapy was compared. Relevant parameters (headache days, headache intensity, headache duration, acute medication, previous prophylaxis treatments) were collected from medical charts of all migraine patients (N = 82) who started treatment with erenumab between November 1st 2018 and May 1st 2019 at two tertiary headache centers in Germany. The sample included 68 female (82.9%) and 14 male patients aged between 22 and 78 years (mean 51.1 years, SD 10.5 years). Of these patients, 57.3% met the criteria for CM and 56.9% overused acute medication. Under therapy with erenumab, a significant reduction of headache days was observed from the first month on. The effect was most pronounced in the third month with a decrease in monthly headache days from 16.6 to 11.6 days (p < 0.001). There was also a significant reduction in reported headache intensity (p = 0.004) and average duration of headache attacks (p = 0.016). The 50% responder rate in patients with CM was lower in the first month compared to EM but then increased similarly to EM. Patients with medication overuse (MO) also responded to the therapy. There was a reduction in medication overuse from 57% at baseline to 29% after therapy (p = 0.011). Overall, a positive result of treatment with erenumab can be shown in a highly selected sample with severely affected migraine patients and a refractory course prior to treatment. This re-confirms the clinical trial data also for this highly selected group.