bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Table S6 from Fraction Dose Escalation of Hypofractionated Radiotherapy with Concurrent Chemotherapy and Subsequent Consolidation Immunotherapy in Locally Advanced Non–Small Cell Lung Cancer: A Phase I Study
Authors: Zhou Rui , Liu FangJie , Zhang HongMei , Wang DaQuan , Zhang PengXin , Zheng ShiYang , Liu YiMei , Chen Li , Guo JinYu , Zou YingYi , Rong Yu-Ming , Liu Hui , Qiu Bo
Published: July 2024

Supplementary Table S6. Clinical efficacy and survival outcomes (n=18).
Supplementary Figure S4 from Immunologic Profiling of Immune-Related Cutaneous Adverse Events with Checkpoint Inhibitors Reveals Polarized Actionable Pathways
Authors: Lacouture Mario E. , Goleva Elena , Shah Neil , Rotemberg Veronica , Kraehenbuehl Lukas , Ketosugbo Kwami F. , Merghoub Taha , Maier Tara , Bang Alexander , Gu Stephanie , Salvador Trina , Moy Andrea P. , Lyubchenko Taras , Xiao Olivia , Hall Clifton F. , Berdyshev Evgeny , Crooks James , Weight Ryan , Kern Jeffrey A. , Leung Donald Y.M.
Published: July 2024

Supplementary Figure S4. Levels of pro-inflammatory mediators, chemokines, and alarmins in the skin tape strip (STS) and plasma samples of patients with cancer experiencing checkpoint inhibitor induced immune-related cutaneous adverse events (ircAEs).
Supplementary Table S3 from Integrating Multisector Molecular Characterization into Personalized Peptide Vaccine Design for Patients with Newly Diagnosed Glioblastoma
Authors: Johanns Tanner M. , Garfinkle Elizabeth A.R. , Miller Katherine E. , Livingstone Alexandra J. , Roberts Kaleigh F. , Rao Venkata Lakshmi P. , Dowling Joshua L. , Chicoine Michael R. , Dacey Ralph G. , Zipfel Gregory J. , Kim Albert H. , Mardis Elaine R. , Dunn Gavin P.
Published: July 2024

pVAC-Seq predicted neoantigens for each subject and each tumor region from whole exome sequencing data
Supplementary Table S1 from Integrating Multisector Molecular Characterization into Personalized Peptide Vaccine Design for Patients with Newly Diagnosed Glioblastoma
Authors: Johanns Tanner M. , Garfinkle Elizabeth A.R. , Miller Katherine E. , Livingstone Alexandra J. , Roberts Kaleigh F. , Rao Venkata Lakshmi P. , Dowling Joshua L. , Chicoine Michael R. , Dacey Ralph G. , Zipfel Gregory J. , Kim Albert H. , Mardis Elaine R. , Dunn Gavin P.
Published: July 2024

Representativeness of study participants
Supplementary Table S3 from Spatial Profiling of Ovarian Carcinoma and Tumor Microenvironment Evolution under Neoadjuvant Chemotherapy
Authors: Yaniz-Galende Elisa , Zeng Qinghe , Bejar-Grau Juan F. , Klein Christophe , Blanc-Durand Felix , Le Formal Audrey , Pujade-Lauraine Eric , Chardin Laure , Edmond Elodie , Marty Virginie , Ray-Coquard Isabelle , Joly Florence , Ferron Gwenael , Pautier Patricia , Berton-Rigaud Dominique , Lortholary Alain , Dohollou Nadine , Desauw Christophe , Fabbro Michel , Malaurie Emmanuelle , Bonichon-Lamaichhane Nathalie , Bello Roufai Diana , Gantzer Justine , Rouleau Etienne , Genestie Catherine , Leary Alexandra
Published: July 2024

Patients and diseases baseline characteristics in the CHIVA neoadjuvant trial
Supplementary Figure S1 from Spatial Profiling of Ovarian Carcinoma and Tumor Microenvironment Evolution under Neoadjuvant Chemotherapy
Authors: Yaniz-Galende Elisa , Zeng Qinghe , Bejar-Grau Juan F. , Klein Christophe , Blanc-Durand Felix , Le Formal Audrey , Pujade-Lauraine Eric , Chardin Laure , Edmond Elodie , Marty Virginie , Ray-Coquard Isabelle , Joly Florence , Ferron Gwenael , Pautier Patricia , Berton-Rigaud Dominique , Lortholary Alain , Dohollou Nadine , Desauw Christophe , Fabbro Michel , Malaurie Emmanuelle , Bonichon-Lamaichhane Nathalie , Bello Roufai Diana , Gantzer Justine , Rouleau Etienne , Genestie Catherine , Leary Alexandra
Published: July 2024

Immune cells distribution in post-placebo and post-BIBF tumors
Supplementary Figure S2 from Monitoring Hepatocellular Carcinoma Using Tumor Content in Circulating Cell-Free DNA
Authors: Lian Shifeng , Lu Chenyu , Li Fugui , Yu Xia , Ai Limei , Wu Biaohua , Gong Xueyi , Zhou Wenjing , Liang Xuejun , Zhan Jiyun , Yuan Yong , Fang Fang , Liu Zhiwei , Ji Mingfang , Zheng Zongli
Published: July 2024

Supplementary Figure S2. Genome-wide copy number profile change in seven HCC patients before and after transarterial chemoembolization (TACE). The colors green, blue, dark red, and red correspond to copy number deletion, neutral, gain, and amplification, respectively
Supplementary Table S3 from Cell-Free Human Papillomavirus DNA Is a Sensitive Biomarker for Prognosis and for Early Detection of Relapse in Locally Advanced Cervical Cancer
Authors: Sivars Lars , Jylhä Cecilia , Crona Guterstam Ylva , Zupancic Mark , Lindqvist Britta , Nordenskjöld Magnus , Tham Emma , Hellman Kristina
Published: July 2024

Supplementary Table S3. ctHPV DNA copies in pretreatment plasma in correlation to tumor size and age at diagnosis.
Supplementary Table S2 from A Cohort Study of CNS Tumors in Multiple Endocrine Neoplasia Type 1
Authors: Graillon Thomas , Romanet Pauline , Camilla Clara , Gélin Camille , Appay Romain , Roche Catherine , Lagarde Arnaud , Mougel Grégory , Farah Kaissar , Le Bras Maëlle , Engelhardt Julien , Kalamarides Michel , Peyre Matthieu , Amelot Aymeric , Emery Evelyne , Magro Elsa , Cebula Hélène , Aboukais Rabih , Bauters Catherine , Jouanneau Emmanuel , Berhouma Moncef , Cuny Thomas , Dufour Henry , Loiseau Hugues , Figarella-Branger Dominique , Bauchet Luc , Binquet Christine , Barlier Anne , Goudet Pierre
Published: July 2024

Sporadic non-meningothelial meningiomas characteristics
Supplementary Table S10 from Integrating Multisector Molecular Characterization into Personalized Peptide Vaccine Design for Patients with Newly Diagnosed Glioblastoma
Authors: Johanns Tanner M. , Garfinkle Elizabeth A.R. , Miller Katherine E. , Livingstone Alexandra J. , Roberts Kaleigh F. , Rao Venkata Lakshmi P. , Dowling Joshua L. , Chicoine Michael R. , Dacey Ralph G. , Zipfel Gregory J. , Kim Albert H. , Mardis Elaine R. , Dunn Gavin P.
Published: July 2024

Differential expression analysis of nCounter CAR-T characterization panel gene expression analyzed via ROSALIND software
Supplementary Table S5 from Integrating Multisector Molecular Characterization into Personalized Peptide Vaccine Design for Patients with Newly Diagnosed Glioblastoma
Authors: Johanns Tanner M. , Garfinkle Elizabeth A.R. , Miller Katherine E. , Livingstone Alexandra J. , Roberts Kaleigh F. , Rao Venkata Lakshmi P. , Dowling Joshua L. , Chicoine Michael R. , Dacey Ralph G. , Zipfel Gregory J. , Kim Albert H. , Mardis Elaine R. , Dunn Gavin P.
Published: July 2024

immunoSEQ resolved TCR sequences for each subject PBMCs pre- and post-NeoVax
Supplementary Table S9 from Integrating Multisector Molecular Characterization into Personalized Peptide Vaccine Design for Patients with Newly Diagnosed Glioblastoma
Authors: Johanns Tanner M. , Garfinkle Elizabeth A.R. , Miller Katherine E. , Livingstone Alexandra J. , Roberts Kaleigh F. , Rao Venkata Lakshmi P. , Dowling Joshua L. , Chicoine Michael R. , Dacey Ralph G. , Zipfel Gregory J. , Kim Albert H. , Mardis Elaine R. , Dunn Gavin P.
Published: July 2024

Immunohistochemistry (IHC) quantification of CD3+ and CD8+ T cells from tumor blocks
Supplementary Table S6 from Integrating Multisector Molecular Characterization into Personalized Peptide Vaccine Design for Patients with Newly Diagnosed Glioblastoma
Authors: Johanns Tanner M. , Garfinkle Elizabeth A.R. , Miller Katherine E. , Livingstone Alexandra J. , Roberts Kaleigh F. , Rao Venkata Lakshmi P. , Dowling Joshua L. , Chicoine Michael R. , Dacey Ralph G. , Zipfel Gregory J. , Kim Albert H. , Mardis Elaine R. , Dunn Gavin P.
Published: July 2024

TCR clonal analysis via immunoSEQ ANALYZER software and The Immune Epitope Database (IEDB) TCRMatch results
Data from Diffuse Pleural Mesotheliomas with Genomic Near-Haploidization: A Newly Recognized Subset with Distinct Clinical, Histologic, and Molecular Features
Authors: Yang Soo-Ryum , Jayakumaran Gowtham , Benhamida Jamal , Febres-Aldana Christopher A. , Fanaroff Rachel , Chang Jason , Gedvilaite Erika , Villafania Liliana B. , Sauter Jennifer L. , Offin Michael , Zauderer Marjorie G. , Ladanyi Marc
Published: July 2024

AbstractPurpose:
Diffuse pleural mesotheliomas (DPM) with genomic near-haploidization (GNH) represent a novel subtype first recognized by The Cancer Genome Atlas project; however, its clinicopathologic and molecular features remain poorly defined.
Experimental Design:
We analyzed clinical genomic profiling data from 290 patients with DPM using the Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT) assay. Allele-specific copy number analysis was performed using the Fraction and Allele-Specific Copy Number Estimates from Tumor Sequencing (FACETS) algorithm.
Results:
A total of 210 patients were evaluable for loss of heterozygosity (LOH) analysis using FACETS from MSK-IMPACT tumor:normal sequencing data. In this cohort, GNH, defined as LOH across >80% of the genome, was detected in 10 cases (4.8%). Compared with non-GNH tumors, GNH DPMs were associated with younger age and less frequent self-reported history of occupational asbestos exposure. Histologically, GNH DPMs were enriched in biphasic subtype (80% vs. 14.5%) and showed abundant tumor-infiltrating lymphocytes (TILs). Genomic analysis revealed a higher frequency of TP53 alterations, whereas SETDB1 mutations were present in nearly all and only in this subset. The clinicopathologic and molecular findings were further validated in a separate cohort. Despite the younger age, patients with GNH DPMs had a shorter overall survival (10.9 vs. 25.4 months, P = 0.004); the poor prognostic impact of GNH remained significant after controlling for biphasic histology. Of three patients with GNH DPMs who received immune checkpoint blockade, two achieved a clinician-assessed partial response.
Conclusions:
GNH defines an aggressive subtype of mainly biphasic DPMs in younger patients with recurrent alterations in SETDB1 and TP53. The enrichment in biphasic histology and TILs, together with our preliminary immune checkpoint blockade response data and anecdotal clinical trial data, suggests that further evaluation of immunotherapy may be warranted in this subset.
Data from Clinical and Biomarker Analysis of a Phase I/II Study of PDR001 Plus Imatinib for Advanced Treatment-Refractory Gastrointestinal Stromal Tumors
Authors: Kim Hyung-Don , Ryu Min-Hee , Park Young Soo , Yoo Changhoon , Kim Sung-Joo , Kang Yoon-Koo
Published: July 2024

AbstractPurpose:
In this phase Ib/II study, we aimed to evaluate the safety and efficacy of PDR001, an anti-PD1 antibody, in combination with imatinib in patients with treatment-refractory gastrointestinal stromal tumor (GIST).
Patients and Methods:
Patients with advanced GIST whose disease had progressed on imatinib, sunitinib, and regorafenib were enrolled. In phase Ib, the standard 3 + 3 dose escalation scheme was applied. Intravenous administration of PDR001 at 400 mg for every 4 weeks plus imatinib (300 and 400 mg daily for dose levels I and II, respectively) was given. The primary outcome for phase II was the disease control rate at 12 weeks. Exploratory biomarker analysis was performed based on PDL1 IHC, next-generation sequencing, and multiplexed IHC.
Results:
No dose-limiting toxicity was observed in the phase Ib part (n = 10), and dose level II was selected as the recommended phase II dose. In the phase II part (n = 29), there was no objective response, and the disease control rate at 12 weeks was 37.9%, not meeting the primary efficacy endpoint. For patients in phase Ib–dose level II and phase II (n = 36), the median progression-free survival (PFS) and overall survival were 2.3 and 9.5 months, respectively. The most common grade 3 to 4 adverse event was anemia. Exploratory biomarker analysis indicated that a higher CD8+ T-cell density was associated with a favorable PFS but to a limited degree. Tumor mutational burden and PDL1 were not associated with better PFS.
Conclusions:
In patients with treatment-refractory GIST, PDR001 in combination with imatinib was generally tolerable, but it was not effective.
Data from Spatial Profiling of Ovarian Carcinoma and Tumor Microenvironment Evolution under Neoadjuvant Chemotherapy
Authors: Yaniz-Galende Elisa , Zeng Qinghe , Bejar-Grau Juan F. , Klein Christophe , Blanc-Durand Felix , Le Formal Audrey , Pujade-Lauraine Eric , Chardin Laure , Edmond Elodie , Marty Virginie , Ray-Coquard Isabelle , Joly Florence , Ferron Gwenael , Pautier Patricia , Berton-Rigaud Dominique , Lortholary Alain , Dohollou Nadine , Desauw Christophe , Fabbro Michel , Malaurie Emmanuelle , Bonichon-Lamaichhane Nathalie , Bello Roufai Diana , Gantzer Justine , Rouleau Etienne , Genestie Catherine , Leary Alexandra
Published: July 2024

AbstractPurpose:
This study investigates changes in CD8+ cells, CD8+/Foxp3 ratio, HLA I expression, and immune coregulator density at diagnosis and upon neoadjuvant chemotherapy (NACT), correlating changes with clinical outcomes.
Experimental Design:
Multiplexed immune profiling and cell clustering analysis were performed on paired matched ovarian cancer samples to characterize the immune tumor microenvironment (iTME) at diagnosis and under NACT in patients enrolled in the CHIVA trial (NCT01583322).
Results:
Several immune cell (IC) subsets and immune coregulators were quantified pre/post-NACT. At diagnosis, patients with higher CD8+ T cells and HLA I+-enriched tumors were associated with a better outcome. The CD8+/Foxp3+ ratio increased significantly post-NACT in favor of increased immune surveillance, and the influx of CD8+ T cells predicted better outcomes. Clustering analysis stratified pre-NACT tumors into four subsets: high Binf, enriched in B clusters; high Tinf and low Tinf, according to their CD8+ density; and desert clusters. At baseline, these clusters were not correlated with patient outcomes. Under NACT, tumors were segregated into three clusters: high BinfTinf, low Tinf, and desert. The high BinfTinf, more diverse in IC composition encompassing T, B, and NK cells, correlated with improved survival. PDL1 was rarely expressed, whereas TIM3, LAG3, and IDO1 were more prevalent.
Conclusions:
Several iTMEs exist during tumor evolution, and the NACT impact on iTME is heterogeneous. Clustering analysis of patients unravels several IC subsets within ovarian cancer and can guide future personalized approaches. Targeting different checkpoints such as TIM3, LAG3, and IDO1, more prevalent than PDL1, could more effectively harness antitumor immunity in this anti-PDL1–resistant malignancy.
Supplementary Figure 4 from CD8-Targeted IL2 Unleashes Tumor-Specific Immunity in Human Cancer Tissue by Reviving the Dysfunctional T-cell Pool
Authors: Kaptein Paulien , Slingerland Nadine , Metoikidou Christina , Prinz Felix , Brokamp Simone , Machuca-Ostos Mercedes , de Roo Guido , Schumacher Ton N.M. , Yeung Yik A. , Moynihan Kelly D. , Djuretic Ivana M. , Thommen Daniela S.
Published: July 2024

Baseline characteristics of CD8-IL2-R and -NR tumors.
Table S3 from Paradoxical Activation of Oncogenic Signaling as a Cancer Treatment Strategy
Authors: Dias Matheus Henrique , Friskes Anoek , Wang Siying , Fernandes Neto Joao M. , van Gemert Frank , Mourragui Soufiane , Papagianni Chrysa , Kuiken Hendrik J. , Mainardi Sara , Alvarez-Villanueva Daniel , Lieftink Cor , Morris Ben , Dekker Anna , van Dijk Emma , Wilms Lieke H.S. , da Silva Marcelo S. , Jansen Robin A. , Mulero-Sánchez Antonio , Malzer Elke , Vidal August , Santos Cristina , Salazar Ramón , Wailemann Rosangela A.M. , Torres Thompson E.P. , De Conti Giulia , Raaijmakers Jonne A. , Snaebjornsson Petur , Yuan Shengxian , Qin Wenxin , Kovach John S. , Armelin Hugo A. , te Riele Hein , van Oudenaarden Alexander , Jin Haojie , Beijersbergen Roderick L. , Villanueva Alberto , Medema Rene H. , Bernards Rene
Published: July 2024

Supplementary table 3: Full list of genes whose knockout attenuated LB-100 toxicity in SW-480 cells in the CRISPR-KO screen FDR smaller or equal to 0.25 and log2 fold change greater or equal to 1 in treated/untreated comparison were criteria for hit selection.
The History of Chromosomal Instability in Genome-Doubled Tumors
Authors: Baker Toby M. , Lai Siqi , Lynch Andrew R. , Lesluyes Tom , Yan Haixi , Ogilvie Huw A. , Verfaillie Annelien , Dentro Stefan , Bowes Amy L. , Pillay Nischalan , Flanagan Adrienne M. , Swanton Charles , Spellman Paul T. , Tarabichi Maxime , Van Loo Peter
Published: June 2024

Tumors frequently display high chromosomal instability and contain multiple copies of genomic regions. Here, we describe Gain Route Identification and Timing In Cancer (GRITIC), a generic method for timing genomic gains leading to complex copy number states, using single-sample bulk whole-genome sequencing data. By applying GRITIC to 6,091 tumors, we found that non-parsimonious evolution is frequent in the formation of complex copy number states in genome-doubled tumors. We measured chromosomal instability before and after genome duplication in human tumors and found that late genome doubling was followed by an increase in the rate of copy number gain. Copy number gains often accumulate as punctuated bursts, commonly after genome doubling. We infer that genome duplications typically affect the landscape of copy number losses, while only minimally impacting copy number gains. In summary, GRITIC is a novel copy number gain timing framework that permits the analysis of copy number evolution in chromosomally unstable tumors.

Significance: Complex genomic gains are associated with whole-genome duplications, which are frequent across tumors, span a large fraction of their genomes, and are linked to poorer outcomes. GRITIC infers when these gains occur during tumor development, which will help to identify the genetic events that drive tumor evolution.

See related commentary by Taylor, p. 1766
The Influence of Cash Ratio, Net Profit Margin, and Company Size on Dividend Policy
Authors: Dea Anggraini  , Utami Ranti , Afriyadi  , Novica Indriaty  , Tommy Munaf
Published: July 2024

The purpose of this study was to determine the effect of cash ratio, net profit margin and company size on dividend policy in consumer non-cyclicals companies listed on the Indonesia Stock Exchange in 2018-2022. The research method used in this research is quantitative. The population in this study were 58 main board consumer non-cyclicals companies listed on the Indonesia Stock Exchange for the period 2018-2022. The sampling technique used in this study was purposive sampling. So that the sample obtained was 21 consumer non-cyclicals companies listed on the IDX for the 2018-2022 period. The results showed that partially cash ratio and net profit margin had no effect on dividend policy. Meanwhile, company size partially has a significant effect on dividend policy.  It can be concluded that cash ratio, net profit margin and company size have an effect on dividend policy. And the Adjusted R-Squared value is 0.736174, which means that the dividend policy is influenced by the Cash Ratio, Net Profit Margin and Company Size by 73.62% and 26.38% is influenced by other variables not examined in this study.
Analysis of How Obesity Affects the Severity of Covid-19 Second Wave on Hospitalized Patients at RSUD Dr. Saiful Anwar Malang
Authors: Cendani Wulan , Djajalakasana Susanthy , Santosa I
Published: July 2024

Background : Based on WHO data, Covid-19 has officially been declared a pandemic because its spread has reached more than 100 infected countries. Several risk factors can affect the severity of Covid-19 patients, one of which is comorbid obesity. The Covid-19 pandemic occurred when the prevalence of overweight/obesity was increasing in almost every country in the world. Chronic inflammation associated with obesity, impaired immune function, and increased expression of ACE 2 contribute to disease severity and worsen clinical outcomes in obese patients with Covid-19 infection.
Aim : This study aims to analyse the effect of obesity on the severity of the second wave of Covid-19 patients who were hospitalized at RSUD dr. Saiful Anwar Malang.
Methods : This research is an analytic observational study with cross sectional approach. The sample consisted of 46 Covid-19 patients with obesity who were hospitalized at RSUD dr. Saiful Anwar Malng. The data acquired will be analysed using Mann Whitney non-parametric analysis test.
Results : In the obese and non-pbese groups, the p-value was 0,042 and the odds ratio was 1,23. In the distribution of age and sex groups, each group obtained a p-value of 0,363 and 0,592.
Conclusion : There is a significant difference in obesity among patients, with a 1,23-fold increased risk of experiencing severity compared to those who are not obese. Meanwhile, for the distribution based on age and sex, there was no significant difference, but it tended to have a more critical degree of severity towards men and older age.
Risk Factor Analysis of Elevated Transaminase Serum in Patients with Dengue Fever at Ngudi Waluyo Wlingi General Hospital in 2023-2024
Authors: Wijayanto Fajar , Insanitaqwa Aleyda
Published: July 2024

Background: Dengue fever has become a global and national health concern due to its increasing incidence rate over the past six years. Dengue infection may present with variable sign and symptoms. Major organ involvement may occur, including liver, which is characterized by an elevated transaminase serum level.
Aim: This study aims to identify factors contributing to increased transaminase serum levels in patients with dengue fever at Ngudi Waluyo Wlingi General Hospital between 2023-2024.
Methods: One hundred and sixty-nine patients with positive dengue serology admitted to Ngudi Waluyo Wlingi General Hospital from January 1st, 2023 to May 19th, 2024, were reviewed retrospectively. Only patients aged 15 years and over with complete laboratory data were included in this retrospective cross-sectional study, using total sampling approach. We collected demographic and laboratory data from electronic medical records, then analyzed and correlated the data with liver function values.
Results: Increased AST levels was observed in 70 patients (41.4%), while ALT values was elevated in 32 patients (24.9%). This increase was significantly linked to decreased platelet counts (p=0). Additionally, age was statistically associated with ALT levels (p=0.022), while gender was significantly related to AST levels (p=0.04). However, leukocyte levels and dengue serology showed no significant correlation with serum transaminase levels (p>0.05). Together, dengue serology, platelet counts, leukocyte levels, gender, and age collectively have a significant effect on AST (14.3%) and ALT (13.6%) values. Among these factors, platelet counts exerted the greatest influence on AST and ALT levels.
Conclusion: Elevated transaminase serum levels may occur in patients with dengue fever. This is associated with platelet counts, age, and gender. Therefore, diagnosing dengue infection should prompt measurement of liver function to ensure appropriate management according to each patient’s condition.
Peripartum Cardiomyopathy Management Strategies: An Evolving Challenge in Maternal Health
Authors: Setyowati Danti Utami , Mayangsari Veny , Tjahjono Cholid
Published: July 2024

Cardiomyopathies are uncommon, although they are significant contributors to serious cardiovascular problems during pregnancy. Prior to pregnancy, it is crucial to have a thorough understanding of the potential dangers linked to cardiomyopathies and how to effectively treat them in pregnant women with significant pre-existing diseases. This knowledge is essential for providing appropriate guidance to patients. Given that all interventions relate to both the mother and the fetus, it is crucial to focus on providing the most efficient care for both. Maternal illness complicates pregnancy in approximately 1-4% of instances. There is a lack of comprehensive data on the frequency and occurrence of heart disease connected to pregnancy in most regions of the world including peripartum cardiomyopathy (PPCM) which was the predominant causes of maternal mortality in the UK in the mid of 2000’s. PPCM may result in persistent systolic dysfunction over an extended period of time. Although heart disease is a prominent, if not the primary, cause of death among pregnant or postpartum women across the country. PPCM is frequently misdiagnosed as a result of insufficient awareness among both medical professionals and the general public. The absence of an early and precise diagnosis of this ailment can have life-threatening implications for women affected by PPCM. Patients who had an early diagnosis saw a more expedited recovery compared to patients who received a late diagnosis. Improving the early monitoring, detection and diagnosis is linked to better recovery.
Nutritional Practices, Quality of Life and, Health Status of Elderly in Rural Communities in Owo Local Government Area, Ondo State, Nigeria
Authors: Daniel Ebenezer , Olanrewaju Omoniyi , Olawale Oluseyi , Bello Ahmed , Tomori Michael , Avwerhota Michael , Popoola Israel , Ogun Adebanke , Salami Aisha , Alewi Olukayode , Popoola Taiwo , Ekwuluo Celestine
Published: June 2024

The study investigates the nutrition practices, health status, and quality of life of elderly individuals in Owo, Ondo State, Nigeria. It involves a descriptive cross-sectional design with 346 elderly participants aged 60-90, systematically sampled from six rural communities. Data were collected via structured, interviewer-administered questionnaires on demographics, medical and lifestyle histories, daily activities, health-seeking behaviors, food consumption, and nutritional care practices. Nutritional status and high blood pressure were assessed using anthropometric indices and a digital sphygmomanometer. Key findings indicate that 37.6% of participants were aged 60-64. Significant differences were noted between sexes in socio-demographic variables. Alcohol consumption, tobacco sniffing, and cigarette smoking were reported by 15.3%, 11.0%, and 4.6% respectively. Additionally, 23.1% were on hypertensive drugs and 20.1% were confirmed diabetics. Meal frequency varied, with 16.5% eating less than three times daily and 59.2% eating three times daily. Lunch (58.0%) and breakfast (36.6%) were the most skipped meals, and 15% ate outside the home. Dietary diversity scores revealed 66.5% with medium and 27.5% with good diversity. Significant gender differences were observed in dietary diversity and consumption patterns of cereals, roots, tubers, and fruits. Nutritional care practices and daily living activities scores showed 90.2% and 80.6% with fair practices and good activity scores, respectively, while 46.2% demonstrated good health-seeking behavior. Common health complaints included body and joint pain. Central obesity rates were 33.8% (WC), 30.3% (WHtR), and 30.6% (WHR). Elevated systolic and diastolic blood pressure were found in 36.7% and 23% of participants, respectively. Only 31.2% reported a good quality of life. Significant positive correlations were found between nutritional status, quality of life, nutritional care practices, and functionality. Malnutrition, poor quality of life, and inadequate care practices among the elderly in rural areas highlight a public health challenge requiring targeted interventions.
Enhanced wound healing potential of arabincoside B isolated from Caralluma Arabica in rat model; a possible dressing in veterinary practice
Authors: Ali Mawada Mohamed , Al-Mokaddem Asmaa Khairy , Abdel-Sattar Essam , El-Shiekh Riham A. , Farag Michael M. , Aljuaydi Samira H. , Shaheed Iman B.
Published: July 2024

Background

Wound management is a critical procedure in veterinary practice. A wound is an injury that requires the body’s cells’ alignment to break down due to external assault, such as trauma, burns, accidents, and diseases. Re-epithelization, extracellular matrix deposition, especially collagen, inflammatory cell infiltration, and development of new blood capillaries are the four features that are used to evaluate the healing process. Using a natural extract for wound management is preferred to avoid the side effects of synthetic drugs. The current study aimed to assess the effect of major pregnane glycoside arabincoside B (AR-B) isolated from Caralluma arabica (C. arabica) for the wound healing process.

Method

AR-B was loaded on a gel for wound application. Rats were randomly distributed into six groups: normal, positive control (PC), MEBO®, AR-B 0.5%, AR-B 1%, and AR-B 1.5%, to be 6 animals in each group. Wounds were initiated under anesthesia with a 1 cm diameter tissue needle, and treatments were applied daily for 14 days. The collected samples were tested for SOD, NO, and MDA. Gene expression of VEGF and Caspase-3. Histopathological evaluation was performed at two-time intervals (7 and 14 days), and immunohistochemistry was done to evaluate α -SMA, TGF-β, and TNF-α.

Result

It was found that AR-B treatment enhanced the wound healing process. AR-B treated groups showed reduced MDA and NO in tissue, and SOD activity was increased. Re-epithelization and extracellular matrix deposition were significantly improved, which was confirmed by the increase in TGF-β and α -SMA as well as increased collagen deposition. TNF-α was reduced, which indicated the subsiding of inflammation. VEGF and Caspase-3 expression were reduced.

Conclusion

Our findings confirmed the efficiency of AR-B in enhancing the process of wound healing and its potential use as a topical wound dressing in veterinary practice.
A Phase I/II Trial of Sapanisertib in Advanced Anaplastic and Radioiodine Refractory Differentiated Thyroid Carcinoma
Authors: Sehgal Kartik , Serritella Anthony , Liu Mofei , ONeill Anne , Nangia Chaitali , Pappa Theodora , Demeure Michael J , Worden Francis P , Haddad Robert I , Lorch Jochen
Published: June 2024

Background

There are limited therapeutic options for patients with recurrent/metastatic anaplastic thyroid carcinoma (ATC) and radioiodine refractory (RAIR) differentiated thyroid carcinoma (DTC) refractory to multikinase inhibitors. This multicenter trial evaluated sapanisertib, a next-generation oral kinase inhibitor of mTOR complexes 1/2, in ATC and RAIR DTC.

Methods

A safety run-in phase I was followed by nonrandomized phase II trial in ATC, with an exploratory cohort in RAIR DTC. The primary endpoint was the proportion of patients with ATC who were without disease progression at 4 months. Safety and survival outcomes were key secondary endpoints.

Results

Forty-six patients (20 ATC, 26 DTC) were enrolled including 40 (18 ATC, 22 DTC) who received recommended phase II dose of 5 mg daily. Eleven percent [2/18, 95% confidence interval (CI): 1.4-34.7%] of patients with ATC were progression-free at 4 months; 22.2% (4/18) had stable disease as best response. Enrollment in the ATC cohort stopped early with 18 patients out of the proposed 23 due to overall futility. One confirmed partial response (4.5%, 1/22) occurred in RAIR DTC, with stable disease in 63.6% (14/22) patients. Median progression-free survival was 1.6 (95% CI: 0.9-2.8) months and 7.8 (2.0–not reached) months in ATC and DTC, respectively. Grade 3 treatment-related adverse events occurred in 30% of patients who received the phase II dose, with the most common being anorexia, nausea, diarrhea, fatigue, skin rash, and hyperglycemia. Genomic alterations in the PI3K/AKT/mTOR pathway were not associated with response or progression-free survival.

Conclusion

Sapanisertib monotherapy did not meet the primary endpoint of this trial (proportion progression-free at 4 months) in ATC and did not show clinically meaningful activity. Clinical trials with alternative therapeutic strategies are needed.
Omega-3 Polyunsaturated Fatty Acids And Adipose Tissue Inflammation: Longitudinal Analysis in the PROMISE Cohort
Authors: Chon Ji-Eun , Semnani-Azad Zhila , Lai Kira Zhi Hua , Connelly Phillip W , Retnakaran Ravi , Harris Stewart B , Metherel Adam H , Jenkins David J A , Bazinet Richard P , Hanley Anthony J
Published: June 2024

Objectives

Although preclinical studies have shown a beneficial impact of omega-3 (n-3) polyunsaturated fatty acids (PUFAs) on adipose tissue (AT) inflammation, the current literature from human studies is limited. Therefore, we aimed to evaluate the longitudinal associations of circulating levels of n-3 PUFAs with biomarkers of AT inflammation.

Methods

Longitudinal data from participants in the PROMISE cohort (n = 474) were used. AT inflammation was measured using circulating biomarkers at baseline and up to 2 follow-up visits. n-3 PUFAs were measured at baseline in 4 serum lipid fractions. Generalized estimating equations analyses evaluated longitudinal associations between n-3 PUFAs and AT inflammation, adjusting for covariates.

Results

Fully adjusted generalized estimating equation models indicated that higher baseline proportions of eicosapentaenoic acid, n-3 docosapentaenoic acid, and docosahexaenoic acid in total serum were significantly inversely associated with longitudinal change in soluble CD163 (all P < .05). A significant positive association of n-3 docosapentaenoic acid and docosahexaenoic acid with longitudinal change in adiponectin (P < .05) was also observed. Generally consistent associations were observed between n-3 PUFAs and soluble CD163 and adiponectin in the four lipid fractions.

Conclusion

These findings will add to the limited evidence on the potential role n-3 PUFAs have in the prevention and management of AT inflammation in humans and may help inform future interventions targeting chronic inflammation at the level of AT.
Establishment of Internal Control and Audit in Insurance Organizations
Authors: Glazkova G.
Published: June 2024

In the context of technological and social changes, business is faced with a more complex business environment. New business models, improved management efficiency, development of internal control and audit in insurance organizations are required. The article suggests approaches to the formulation of internal audit, the development of a methodology for its implementation. The methodological basis of the research is a systematic approach, a method of analyzing the current processes in the financial market, collecting facts, and structural and functional modeling.
Modern Aspects of Accounting for Intangible Assets: Analysis of Key Risks
Authors: Rozhnova Olga , Safonova Irina
Published: June 2024

The article highlights the issues of presenting information to various groups of stakeholders about the company’s potential risks associated with the reflection of already recognized and created intangible assets that are characteristic of an economy in the stage of innovative and digital changes. An analysis was carried out on the most significant aspects of accounting for intangible assets and disclosure in reporting regarding the risks inherent in intangible assets compared to tangible ones. The characteristic types of risks of various types of intangible assets have been identified; risks of intangible assets, the most significant in terms of possible impact on profit/loss indicators. Modern types of potential intangible assets and their inherent risks have been identified. Proposals how to improve the reliability of reporting information on intangible assets have been formulated.
Methodology for the formation of elementary quantitative concepts in preschoolers with intellectual disabilities
Authors: Chumakova I.
Published: June 2024

The article discusses the importance of the formation of elementary quantitative concepts in preschoolers with intellectual disabilities, since this has a corrective effect on their mental processes and cognitive activity. A method for forming quantitative ideas in children of the studied category is presented.
Evaluation of the effectiveness of the health-saving approach in the implementation of the practical discipline of physical education in a medical university
Authors: Skiba Igor , Ibragimov Ildar , Hamidullina Guzel
Published: June 2024

This article discusses the effectiveness of the health-saving approach in the implementation of the practical discipline of physical culture in a medical university. The study was conducted on the basis of the Kazan State Medical University, which was attended by 40 female students studying at the Faculty of Medicine and having a basic health group. The classes of the control group during the academic year were conducted according to the health-saving RPD, which includes four modules of a one-year training cycle, in each of which certain tasks are solved. To assess the effectiveness of the approach, at the beginning and at the end of the experiment (academic year), students passed the TRP standards of the 7th stage. Taking into account the data obtained as a result of the experiment, it can be stated that the RPD developed according to the health-saving approach allows developing the physical qualities of medical students by an average of 3.8%.
Development of creative imagination in preschoolers by means of play
Authors: Ovchinnikova A. , Rada V.
Published: June 2024

The article describes the trends in the development of creative imagination in children of middle preschool age; the author's definition of this phenomenon is given; criteria, indicators, methods and levels of development of creative imagination in preschoolers are determined; the methods of developing creative imagination in preschoolers used in the game are proposed; comparative results of empirical research are given.
The Evolution of the Principle of Shared Responsibility in the Area of European Integrated Border Management
Authors: Parol Agnieszka
Published: July 2024

The article includes a legal analysis of the principle of shared responsibility, which is the current basis for implementing European Integrated Border Management (EUIBM). In particular, the article analyzes the main instruments strengthening the institutional position of the European Union in border management, that is, the Frontex standing service and its powers to apply coercive measures and the obligation of Member States to cooperate with the agency. There are three stages in the evolution of the principle of shared responsibility. The first stage begins with the reform of the EUIBM system resulting from the then migration pressure, initiated by the European Commission’s communication of December 2015 and the European Border and Coast Guard (ESGiP) Regulation of 2016, replacing the original Frontex Regulation. The reform allowed for the adoption of the first binding definition of European integrated border management and introduced the principle of shared responsibility. The second stage is marked by the ESGiP reform of 2019, which significantly expanded Frontex’s competences by establishing the agency’s force corps. The third stage, carried out during the period of intensifying geopolitical changes in Europe and the world, begins with the adoption in 2023 of the first multi-annual program implementing and aimed at the effective implementation of EUIBM, the so-called “strategic policy.” The article puts forward the thesis that geopolitical conditions favoring the tendency to tighten operational cooperation have enabled the Union to build an EUIBM based on the principle of shared responsibility and a significant evolution of the principle itself. It seems that EUIBM in its current formula has exhausted the treaty possibilities and further expansion of the system should be preceded by a treaty reform.
Endodontic irrigants from a comprehensive perspective
Authors: Khoury Rayana Duarte , de Carvalho Lara Steffany , do Nascimento Mauro Felipe Rios , Alhussain Fadi , Abu Hasna Amjad
Published: June 2024

This review article explores the fundamental principles of modern endodontics with a focus on root canal cleaning and shaping. It reviews commonly used endodontic irrigant, namely sodium hypochlorite (NaOCl), herbal extracts, chlorhexidine (CHX), and chelating agents, highlighting their properties, applications, and potential drawbacks. NaOCl, a key antimicrobial agent, demonstrates effectiveness against various microorganisms but poses challenges such as high cytotoxicity. Herbal extracts, gaining recognition in endodontics, present an alternative with potential advantages in preserving dentin integrity. CHX, known for its broad-spectrum antimicrobial activity, is discussed in both liquid and gel formulations, emphasizing its role in reducing smear layer formation and preserving hybrid layer durability. Chelating agents, specifically ethylenediaminetetraacetic acid and citric acid, play a vital role in removing the smear layer, enhancing dentin permeability, and facilitating the penetration of antimicrobial agents. The review article underscores the importance of careful application and consideration of each irrigant's properties to ensure safe and effective endodontic procedures. It serves as a valuable guide for clinicians in selecting appropriate irrigants based on specific treatment requirements.
Functional assessment and influencing factors after staged functional training in patients with ankle fractures
Authors: Fang Min-Qiong
Published: June 2024

BACKGROUND

The recovery of limb function after ankle fracture surgery is a gradual process. The main purpose of implementing early functional exercise, joint mobility, muscle contraction function, passive ankle flexion and extension exercises, or physical factor therapy techniques is to achieve the rapid recovery of normal physiological limb function. However, currently the most effective rehabilitation training method is staged limb functional exercise, which promotes rapid recovery of limb function while preventing adverse consequences caused by overwork or insufficient training. Staged limb functional exercise divides the rehabilitation process into multiple stages, each of which has specific training objectives and contents. This method helps patients gradually restore limb function. Nevertheless, some patients still exhibit poor limb function after standardized exercise. Therefore, a functional evaluation should be performed to analyze the impact of staged functional training after ankle fracture surgery.

AIM

To perform a functional evaluation and determine the influencing factors of staged functional training in patients with ankle fracture.

METHODS

A retrospective study enrolled 150 patients who underwent surgical treatment for ankle fracture from May 2020 to May 2022 at our hospital. Univariate and multivariate linear regression analyses were performed on general data, functional exercise compliance scale for orthopedic patients, Social Support Rating Scale (SSRS), American Orthopedic Foot and Ankle Score (AOFAS) Ankle-Hindfoot Score, and pain factors [serum bradykinin (BK), prostaglandin E2 (PGE2), 5-hydroxytryptamine (5-HT)].

RESULTS

Based on the AOFAS Ankle-Hindfoot Scale, the cases were divided into the excellent function (n = 111) and ordinary function (n = 39) groups. Univariate analysis revealed that monthly family income, education level, diabetes mellitus, functional exercise compliance scale of orthopedic patients score, SSRS, BK, PGE2, and 5-HT significantly influenced limb function after ankle fracture (P < 0.05); Multiple linear regression analysis showed that the functional exercise compliance scale score, SSRS, BK, PGE2, and 5-HT were independent risk factors affecting functional performance after staged functional exercise (P < 0.05).

CONCLUSION

Exercise compliance, SSRS, and pain level are the independent risk factors affecting functional performance after staged functional training following ankle surgery. Clinical nursing care after ankle surgery should include analgesic and health education measures to ensure optimal recovery of limb function.
Effect of psychological nursing intervention combined with acupressure on postoperative recovery of women after cesarean section
Authors: Liu Xing-Ying , Chen Xiao-Bo , Wen You-Liang , Guo Xiao-Ping , Zhou Xiao-Bin
Published: June 2024

BACKGROUND

Psychological intervention nursing (PIN) has been considered to have a curative effect on cesarean section (CS) postoperative recovery. However, the therapeutic mechanisms remain obscure.

AIM

To explore the effects of PIN combined with acupressure massage on CS postoperative recovery.

METHODS

A retrospective study was conducted on 150 pregnant women admitted to an obstetrics department between January 2020 and January 2023. The control group (CG) received acupressure therapy (n = 73), and the intervention group (IG) received acupressure therapy and PIN therapy (n = 77). Postoperative recovery time was assessed by anal-exhausting, defecation, bed activity, breastfeeding, and hospital stay times. Adverse effects, including infection, bleeding, limb numbness, intrauterine hematoma, urinary retention, and venous thromboembolism, were recorded. the pain visual analogue scale (VAS) was used to evaluate the degree of pain. Anxiety and depression status were qualitatively assessed using the self-rating anxiety scale (SAS), self-rating depression scale (SDS), and Edinburgh postpartum depression scale (EPDS). The Pittsburgh sleep quality index (PSQI) was used to compare sleep quality between the groups.

RESULTS

The baseline data and SAS, SDS, EPDS, and PSQI scores did not significantly differ before CS (P > 0.05) and neither did complication rates between the two groups after CS (P > 0.05). However, anal-exhausting, defecation, waking up, breastfeeding, and hospitalization times were significantly shorter for participants in the IG than those for participants in the CG (P < 0.05). The VAS, SAS, SDS, EPDS, and PSQI scores of the IG were significantly lower than those of the CG (P < 0.05).

CONCLUSION

PIN, combined with acupressure massage, effectively promotes maternal recovery, reduces post-CS pain, and improves postoperative negative emotions and sleeping quality.
Effect of electroacupuncture combined with rehabilitation techniques on shoulder function in patients with rotator cuff injuries
Authors: Chen Zhi-Ying , Wang Meng-Hua , Ye Zhong
Published: June 2024

BACKGROUND

The rotator cuff is located below the acromion and deltoid muscles and comprises multiple tendons that wrap around the humeral head, maintaining shoulder joint stability.

AIM

To explore the effect of electroacupuncture combined with rehabilitation techniques on shoulder function in patients with rotator cuff injuries.

METHODS

We selected 97 patients with rotator cuff injuries treated in the People's Hospital of Yuhuan from February 2020 to May 2023. Patients were grouped using the envelope method.

RESULTS

After treatment, the study group’s treatment effective rate was 94.90% (46/49 patients), significantly higher than that in the control group (79.17%, 38/48 cases; P < 0.05). Before treatment, there was no difference in Constant Murley Score (CMS) scores, shoulder mobility, or 36-Item Short Form Health Survey (SF-36) scale scores (P > 0.05). Compared with those before treatment, the CMS scores (including pain, daily living ability, shoulder mobility, and muscle strength), all aspects of shoulder mobility (forward flexion, posterior extension, external rotation, internal rotation), and SF-36 scale scores (including physiological, psychological, emotional, physical, vitality, and health status) were higher in both groups after treatment and significantly higher in the study group (P < 0.05). There was no difference in the occurrence of complications between the two treatment groups (P > 0.05).

CONCLUSION

Electroacupuncture combined with rehabilitation techniques has a good treatment effect on patients with rotator cuff injuries, helps accelerate the recovery of shoulder function, improves the quality of life, and is highly safe.