bluuebunny/crossref_metadata_2025 huggingface dataset:
FOXO3a/miR-4259-driven LDHA expression as a key mechanism of gemcitabine sensitivity in pancreatic ductal adenocarcinoma
Authors: Hsu Tung-Wei , Wang Wan-Yu , Chen Hsin-An , Wang Tzu-Hsuan , Su Chih-Ming , Liao Po-Hsiang , Chen Alvin , Tsai Kuei-Yen , Kokotos George , Kuo Cheng-Chin , Chiu Ching-Feng , Su Yen-Hao
Published: February 2025

Background

Lactate dehydrogenase A (LDHA) can regulate tumorigenesis and cancer progression. Nevertheless, whether the regulation of LDHA is involved in the development of gemcitabine resistance in PDAC has not yet been fully elucidated. Increasing studies have shown that cancer acquired drug resistance led to treatment failure is highly attributed to the cancer stem cell (CSC) properties. Therefore, we aim to demonstrate the functions and regulatory mechanisms of LDHA on cancer stem cell (CSC) properties and gemcitabine resistance in PDAC.

Methods

We investigate the metabolite profiles by liquid chromatography-mass spectrometry between gemcitabine–resistant PDAC and parental PDAC cells. Additionally, gain-of-function and loss-of-function experiments were conducted to examine the roles of LDHA on CSC properties and gemcitabine resistance in the gemcitabine–resistant PDAC and parental PDAC cells. To investigate regulators involved in LDHA-mediated gemcitabine resistance and CSC of pancreatic cancer cells, we further used a combination of the miRNA microarray results and software predictions and confirmed that miR-4259 is a direct target of LDHA by luciferase assay. Furthermore, we constructed serial miR-4259 promoter reporters and searched for response elements using the TESS 2.0/TFSEARCH software to find the transcription factor binding site in the promoter region of miR-4259.

Results

We observed that elevated LDHA expression significantly correlates with recurrent pancreatic cancer patients following gemcitabine treatment and with CSC properties. We further identify that FOXO3a-induced miR-4259 directly targets the 3’untranslated region of LDHA and reduced LDHA expression, leading to decreased gemcitabine resistance and a reduction in the CSC phenotypes of pancreatic cancer.

Conclusion

Our results demonstrated that LDHA plays a critical role in cancer stemness and gemcitabine resistance of pancreatic cancer, and indicate that targeting the FOXO3a/miR-4259/LDHA pathway might serve as a new treatment for pancreatic cancer patients with a poor response to gemcitabine chemotherapy.
The German version of the Bergen Yale Sex Addiction Scale (BYSAS): psychometric properties and initial steps of validation
Authors: Hiebler Michaela , Brössler Hannah , Wimmer Raphael , Zipper Zoe , Renner Elisa , Brouschek Jasmin , Fuchshuber Jürgen , Neubauer Aljoscha , Unterrainer Human-Friedrich
Published: February 2025

Objectives

This study presents the German version of the Bergen Yale Sex Addiction Scale (BYSAS). The questionnaire screens for different risk levels of problematic excessive sexual behavior (“hypersexuality”).

Methods

Based on an online sample (N = 492), a confirmatory factor analysis as well as other reliability analysis were conducted. Demographic characteristics of the sample were also assessed. The BYSAS was validated with psychiatric symptoms.

Results

Global fit statistics indicate a one-factorial structure of the BYSAS. Cronbach’s α was 0.77. 2.03% of the study participants were categorized as “high risk” regarding sex addiction.

Discussion

Initial results suggest that the German version of the BYSAS is a promising screening instrument for sex addiction. However, further validation in clinical populations is essential to ensure generalizability and clinical utility. In addition, different risk levels as well as the mechanisms underlying hypersexuality need to be examined more closely.
The challenge of the application of augmented reality in science education in China: a systematic review
Authors: Zhang Sifang , Yao Zhuangzhuang
Published: February 2025

Augmented reality (AR) technology has brought innovative changes to the field of education with its unique interactivity and immersion. In recent years, the application of AR technology in science education in China has been researched and practiced. This article reviews these studies and explores the various disciplinary areas of AR technology application in science education, the types of devices used, as well as the application advantages, challenges, and future trends of AR technology. It is found that the application of augmented reality technology in China’s science education has broad prospects and potential. However, there are still some challenges, such as equipment cost, teacher training and technology maturity. In the future, with the progress of technology and the deepening of application, AR technology in China’s science education will gain more extensive and deeper application.
Detection, isolation, characterization, analytical method development with validation and in-silico analysis of new impurity in rivaroxaban
Authors: Epuru Manohar Reddy , Saroja Jagadam , Pilli Veera Venkata Nanda Kishore , Vennapureddy Ravinder Reddy
Published: February 2025

Background

For rivaroxaban (RRBN) to be safe and effective, its quality and impurities need to be evaluated. One new impurity (IMP-20.15/2.57) was found during the analysis of intermediate stage compound of RRBN production. The isolation of IMP-20.15/2.57 was achieved by preparative HPLC, using 10 mM ammonium acetate and acetonitrile (gradient elution mode) as mobile phase. The IMP-20.15/2.57 was elucidated using mass spectrometer, FT-IR and NMR (1H and 13C) techniques. A gradient RP-HPLC method was developed for IMP-20.15/2.57 quantification in RRBN API. The chromatographic separation of IMP-20.15/2.57 was done on a Zorbax Eclipse XDB [C18 3.0 mm × 15 cm, 3.5 µm] column with UV detection programmed at 250 nm. Solution A (methanol and buffer have been blended in a 05:95 v/v ratio) and Solution B (acetonitrile) make up the gradient mobile phase. The three batches of RRBN API were analyzed with the developed gradient RP-HPLC approach for the content of IMP-20.15/2.57. Risk assessment tests for IMP-20.15/2.57 were conducted utilizing in silico programs.

Results

The IMP-20.15/2.57 was elucidated as 4-(4-(2-hydroxy-3-(2-hydroxy-3-(4-(3-oxomorpholino) phenyl amino) propyl amino) propyl amino) phenyl) morpholin-3-one using mass spectrometer, FT-IR and NMR (1H and 13C) techniques. The novel approach was evaluated in accordance with ICH requirements for linearity (0.2495–1.4971 µg/mL; R2-0.99958), accuracy (109.97–117.71% recovery), precision (0.6015–0.9211%RSD), specificity (996.5 peak purity), robustness (no significant variation in retention time and resolution), and quantification limitations (0.2495 µg/mL). The results were deemed appropriate. It became apparent that the IMP-20.15/2.57 content in three batches of RRBN API were below the quantification limits. The in-silico program suggested that there was certainly no possibility of mutagenicity with IMP-20.15/2.57.

Conclusion

The present gradient RP-HPLC approach suits best for the IMP-20.15/2.57 quantification in RRBN API and offers more effective ways to guarantee the safety of patients and the quality of RRBN.
Incidence of complications and outcome in live kidney transplant recipients at 1 year—a single center experience
Authors: Khan Imran , Wani Muzamil Ahmad , Wani Imtiyaz Ahmad , Rather Jawad Iqbal , Bhat Mohammad Ashraf , Wani Muzafar Maqsood , Sheikh Rayees Yousuf , Parry Manzoor Ahmad
Published: February 2025

Introduction

Patients with end-stage kidney disease (ESKD) need ongoing dialysis treatments or a kidney transplant to survive. Kidney transplantation is the optimal treatment for patients with ESKD. Advances in surgical, immunosuppressive, and monitoring protocols have led to a significant improvement in short-term kidney allograft survival. However, in order to avoid rejection, kidney transplant patients have to be on immunosuppression which increases the risk of infections, malignancies, cardiovascular diseases, and many other complications. So a balance has to be struck to prevent under or over-immunosuppression.

In this study, we present our experience and follow-up data of kidney transplantations done at our center with special emphasis on the incidence of complications and outcomes in recipients at 1 year.

Aims and objectives

1. To estimate the incidence of post-transplant complications in live kidney transplant recipients at 1 year.

2. To assess the patient and graft survival at 1 year in live kidney transplant recipients.

Materials and methods

This observational study was done in the Department of Nephrology, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, J&K. Patients who underwent transplant at our center from April 2022 to April 2023 were included and each patient was followed up for 1 year in this study. All the consenting kidney transplant recipients undergoing kidney transplantation at our center during the study period were included.

Results

A total of 45 kidney transplants were included in the study. The mean age of our study population was 31.2 years (SD 10.5). 77.5% of our recipient population comprised of men and 22.5% were women. The mean dialysis vintage was 15.1 months (SD 9.4). The incidence of biopsy-proven acute rejection was 15% while 1 year patient and graft survival were 100% and 95%, respectively. The incidence of BK virus-associated nephropathy was 10%. The overall incidence of other infections was 37.5%. The incidence of hypertension and post-transplant diabetes was 65% and 15%, respectively. The incidence of anemia and erythrocytosis was 12.5% and 22.5%, respectively.

Conclusion

Kidney transplant is the treatment of choice for ESKD. However, these patients are at risk of infectious, malignant, cardiometabolic, and other complications. Heightened awareness and surveillance is of utmost importance in these patients.
Flashbacks uniquely characterise post-traumatic stress disorder: distinguishing flashbacks from other psychological processes and phenomena
Authors: Siddaway Andy P.
Published: February 2025

The post-traumatic stress disorder (PTSD) diagnosis encompasses heterogeneous presentations, many of the diagnostic criteria are not trauma-related and almost all PTSD symptoms are common to several psychiatric diagnoses. Flashbacks are the only symptom unique to PSTD. However, the absence of a consensus definition of flashbacks means that this term means different things to different people, causing misunderstanding and miscommunication, and presumably affecting treatment. This Refreshment discusses how flashbacks are defined in DSM-5-TR and ICD-11 (essentially, as reliving/re-experiencing when awake) and briefly describes the dual representation theory's account of flashbacks. In discussing what flashbacks are and are not, it aims to promote improved understanding, assessment and diagnosis of PTSDs.
The epidemiology and phenomenology of non-antipsychotic-induced dystonia: a hybrid systematic-narrative review
Authors: Catthoor Kirsten , Detraux Johan , De Hert Marc
Published: February 2025

Background

Medication-induced dystonia (MID) is a movement disorder (MD), characterized by involuntary sustained or intermittent muscle contractions, causing abnormal, often repetitive, movements, postures, or both. Although MID is commonly associated with the use of antipsychotics, it also occurs with many other medications widely used in clinical practice.

Methods

A systematic literature search (from inception to November 2023), using the PubMed and Embase databases, was conducted without language restriction for articles reporting on MID in people without pre-existing MDs, and this for all potentially relevant non-antipsychotic medications. A narrative synthesis of the available evidence was undertaken.

Results

MID is common (1 to 10%) with certain antiemetics. Selective serotonin reuptake inhibitors and the antiepileptics valproate, carbamazepine, and lamotrigine are rarely (0.01 to 0.1%) or very rarely (<0.01%) associated with MID. All other medications are very rarely (<0.01%) associated with MID or have a risk that cannot be precisely estimated. The actual rate of dystonic reactions with most non-antipsychotic agents remains unknown, owing to misdiagnosis and underreporting in the scientific literature. In general, MID seems to occur more often in children and adolescents, even with a single low dose, and with polymedication. In most cases, MID is acute in onset (occurring within hours to days) and involves the head and neck.

Conclusions

Although MID is most common with dopamine receptor-blocking antiemetics, many other medications may also produce dystonic reactions, particularly in children and adolescents. Although such incidents remain rare, there are indications that MID is underreported for many classes of medications.
The non-canonical Smoothened-AMPK axis regulates Smaug1 biomolecular condensates
Authors: Thomas María Gabriela , Fernández-Alvarez Ana Julia , Giménez Macarena , Aristarain Francisco Corvetto , Cozza Lucas Helio , Pimentel Jerónimo , Pessoa João , Pascual Malena Lucía , Boscaglia Lara , Habif Martín , Corbat Agustín , La Spina Pablo Ezequiel , Peters Tomás , Bustos Diego Martín , Carmo-Fonseca Maria , Grecco Hernán Edgardo , Boccaccio Graciela Lidia
Published: February 2025

Biomolecular condensates (BMCs) emerge as important players in RNA regulation. The RNA binding protein Smaug forms cytosolic BMCs in mammals, insects and yeasts and affects mitochondrial function and/or responses to nutrient deprivation. Here we found that the non-canonical activation of the SMO-AMPK pathway known to affect energy metabolism triggers the immediate disassembly of BMCs formed by a number of human and rodent Smaug orthologs, whereas processing bodies remained rather unaltered. A non-phosphorylatable SMO mutant abrogated the effect, involving SMO phosphorylation in hSmaug1 BMCs regulation. Three mechanistically different SMO ligands, namely SAG; GSA-10 and cyclopamine elicited a similar response, which was blocked upon AMPK pharmacological inhibition. Polysome disassembly by puromycin halted Smaug1 BMC dissolution, thus suggesting that unbound transcripts became translationally active. Single-molecule fluorescent in situ hybridization illustrated the release of UQCRC1 mRNA. Finally, Smaug1 is a phosphoprotein bound by 14-3-3 proteins and the competitive inhibitor difopein blocked the response to non-canonical SMO stimulation. We propose that the regulated condensation and dispersion of Smaug1 BMCs generate translational changes that contribute to metabolic regulation downstream of the non-canonical SMO-AMPK axis.
Actin from within – how nuclear myosins and actin regulate nuclear architecture and mechanics
Authors: Gawor Marta , Lehka Lilya , Lambert Danielle , Toseland Christopher P.
Published: February 2025

Over the past two decades, significant progress has been made in understanding mechanotransduction to the nucleus. Nevertheless, most research has focused on outside-in signalling orchestrated by external mechanical stimuli. Emerging evidence highlights the importance of intrinsic nuclear mechanisms in the mechanoresponse. The discovery of actin and associated motor proteins, such as myosins, in the nucleus, along with advances in chromatin organisation research, has raised new questions about the contribution of intranuclear architecture and mechanics. Nuclear actin and myosins are present in various compartments of the nucleus, particularly at sites of DNA processing and modification. These proteins can function as hubs and scaffolds, cross-linking distant chromatin regions and thereby impacting local and global nuclear membrane shape. Importantly, nuclear myosins are force-sensitive and nuclear actin cooperates with mechanosensors, suggesting a multi-level contribution to nuclear mechanics. The crosstalk between nuclear myosins and actin has significant implications for cell mechanical plasticity and the prevention of pathological conditions. Here, we review the recent impactful findings that highlight the roles of nuclear actin and myosins in nuclear organisation. Additionally, we discuss potential links between these proteins and emphasize the importance of using new methodologies to unravel nuclear-derived regulatory mechanisms distinct from the cytoskeleton.
Μελέτη ποιότητας και αυθεντικότητας Ελληνικών μελιών προερχόμενα από διαφορετικά φυτά και φυλές μελισσών βάσει του φαινολικού τους περιεχομένου
Authors: Ντάκουλας Δημήτριος
Published: February 2025

Ο σκοπός της παρούσας διατριβής ήταν η μελέτη της ποιότητας και της αυθεντικότητας των Ελληνικών μελιών με βάση το φαινολικό τους περιεχόμενο. Αρχικά συλλέχθηκαν 132 δείγματα μελιού από την Ελλάδα και άλλες χώρες. Στη συνέχεια πραγματοποιήθηκε γυρεοσκοπική ανάλυση για την ταξινόμηση των μελιών στα επιμέρους είδη, προσδιορίστηκαν οι τιμές HMF, διαστάσης, ηλεκτρικής αγωγιμότητας, το ολικό φαινολικό περιεχόμενο και 23 επιμέρους φαινολικές ενώσεις. Πραγματοποιήθηκε σύγκριση ως προς τα φυσικοχημικά χαρακτηριστικά, το ολικό φαινολικό περιεχόμενο και την περιεκτικότητα στις επιμέρους φαινολικές ενώσεις μεταξύ των διαφόρων ειδών Ελληνικού μελιού, μεταξύ Ελληνικών μελιών και μελιών προερχόμενα από άλλες χώρες καθώς και μεταξύ μελιών μελιτώματος και μελιών ανθέων. Πραγματοποιήθηκε μελέτη αυθεντικότητας με χρήση διαφόρων στατιστικών δοκιμών και μεθόδων και διαπιστώθηκε ότι η φαινολική ένωση χλωρογενικό οξύ μπορεί να χρησιμοποιηθεί ως δείκτης για το Ελληνικό μέλι καστανιάς, το ομογεντισικό οξύ και το 2-cis,4-trans-αµπσισικό οξύ ως δείκτες για το Ελληνικό μέλι κουμαριάς, η εσπεριδίνη για το μέλι πορτοκαλιάς και η ταξιφολίνη για τα Κυπριακά μέλια θυμαριού. Επίσης με εφαρμογή γραμμικής διαχωριστικής ανάλυσης (LDA) επιτεύχθηκε 90% ορθός διαχωρισμός για τα ελληνικά δείγματα βελανιδιάς χρησιμοποιώντας ως ανεξάρτητες μεταβλητές το πρωτοκατεχικό οξύ και το γαλλικό οξύ. Σε μέρος των δειγμάτων από αυτά που συγκεντρώθηκαν, τα οποία αποτελούνταν από 7 είδη μελιού, πραγματοποιήθηκε επιπλέον φασματοσκοπικός προσδιορισμός μέσω φασματοσκοπίας υπέρυθρου μετασχηματισμού Fourier (FTIR), προσδιορισμός της περιεκτικότητας των κυρίων σακχάρων καθώς επίσης και μελέτη της βιοενεργότητας μέσω του προσδιορισμού της ενεργότητας της ακετυλοχολινεστεράσης και της παγκρεατικής λιπάσης.
Recent Advances in Biopesticide Research and Development with a Focus on Microbials
Authors: Tadesse Mawcha Kahsay , Malinga Lawrence , Muir Debbie , Ge Jing , Ndolo Dennis
Published: February 2025

Biopesticides are pest control products derived from natural sources such as microbes, macro-organisms (insects and pathogens), plant extracts, and certain minerals. Many biopesticides are considered environmentally safe and can complement or substitute conventional chemical pesticides. They can also be highly specific or broad spectrum with a unique mode of action controlling a wide range of pest species. Due to their target-specificity and low to no environmental residuality, biopesticides conform to the 3 pillars of Climate-Smart Agriculture, the Sustainable Development Goals, and, ultimately, the Paris Agreement. This review focuses largely on microbial biopesticides derived from fungi, bacteria, viruses, and nematodes. It discusses (i) the various microbial biopesticide formulations, (ii) the mode of microbial biopesticide action, (iii) the factors that affect the potential efficacy of biopesticides, (iv) challenges to the adoption of microbial biopesticides, and (v) the role of microbial biopesticides in Integrated Pest Management programs. Finally, advancements in application techniques, as well as future research directions and gaps, are highlighted.
The genome sequence of the muscid fly Eudasyphora cyanicolor (Zetterstedt, 1845)
Authors: Falk Steven , Crowley Liam M. , Akinmusola Ruth Y. ,   University of Oxford and Wytham Woods Genome Acquisition Lab,   Darwin Tree of Life Barcoding collective,   Wellcome Sanger Institute Tree of Life Management, Samples and Laboratory team,   Wellcome Sanger Institute Scientific Operations: Sequencing Operations,   Wellcome Sanger Institute Tree of Life Core Informatics team,   Tree of Life Core Informatics collective,   Darwin Tree of Life Consortium
Published: February 2025

We present a genome assembly from an individual female specimen of Eudasyphora cyanicolor (Arthropoda; Insecta; Diptera; Muscidae). The genome sequence has a total length of 1,450.40 megabases. Most of the assembly (99.68%) is scaffolded into 5 chromosomal pseudomolecules. The mitochondrial genome has also been assembled and is 19.34 kilobases in length.
The genome sequence of the acute-angled fungus beetle, Cryptophagus acutangulus Gyllenhal, 1827
Authors: Barclay Maxwell V. L. , Telnov Dmitry ,   Natural History Museum Genome Acquisition Lab,   Darwin Tree of Life Barcoding collective,   Wellcome Sanger Institute Tree of Life Management, Samples and Laboratory team,   Wellcome Sanger Institute Scientific Operations: Sequencing Operations,   Wellcome Sanger Institute Tree of Life Core Informatics team,   Tree of Life Core Informatics collective,   Darwin Tree of Life Consortium
Published: February 2025

We present a genome assembly from an individual male specimen of Cryptophagus acutangulus (acute-angled fungus beetle; Arthropoda; Insecta; Coleoptera; Cryptophagidae). The genome sequence has a total length of 177.30 megabases. Most of the assembly (83.62%) is scaffolded into 18 chromosomal pseudomolecules, including the X1, X2 and Y sex chromosomes. The mitochondrial genome has also been assembled and is 20.2 kilobases in length.
GenoCare Prognosticator Model: Host Genetics Predict Severity of Infectious Disease
Authors: Dubey Shivendra , Singh Shweta , Verma Dinesh Kumar , Lodhi Sudheer Kumar , Dubey Sakshi
Published: February 2025

Scientific community understanding of the variance in severity of infectious disease like COVID-19 across patients is an important area of focus. The article presents an innovative voting ensemble GenoCare Prognosticator (GCP) model that incorporates XGBoost and Random Forest classifiers, two cutting-edge machine learning approaches. A large dataset that incorporates medical covariates like gender and age along with biological WES (Whole Exome Sequencing) data was used to train these models. Five-fold stratified cross-validation was used to process the dataset in order to improve model stability and avoid overfitting. Two medical covariates and sixteen recognized candidate gene variants were among the eighteen major features on which our GCP model had been verified using data from earlier studies. Specific post-hoc clarification of the model’s predictions was provided by ExplainerDashboard, a Python open-source library, to improve interpretability. Furthermore, we utilized OpenTarget and Enrichr, two bioinformatic resources, to establish connections between the discovered variations in genetics and pertinent ontologies, biological pathways, and possible drug/disease relationships. Unsupervised clustering of SHAP key feature values was included in the analysis, which revealed intricate genetic interactions that affect the severity of the disease. Our results show that although gender and age are the main factors influencing the severity of COVID-19, complex genetic interactions cause severe symptoms in a specific subset of patients. This work contributes to our comprehension of the biological variables influencing the severity of COVID-19 and offers a reliable, comprehensible model that can help recognize patients at high risk and guide individualized treatment plans.
Design of Security and Privacy Models for Optimizing the Selection of Cloud Service Providers in Cloud Computing Environments
Authors: Yang Fan , Tian Fuqiang , Wu Hongyu , Mou Jun , Dong Shilei , Lin Maonan
Published: February 2025

In order to solve the problem of difficult access to personalized and high-quality services for cloud users, the author proposes a security and privacy model for optimizing the selection of cloud service providers in the cloud computing environment. This model first divides user nodes into three types based on historical transactions between nodes: familial nodes, unfamiliar nodes, and ordinary nodes; Secondly, in order to protect the privacy information feedback from nodes, a trust evaluation agent is introduced as the subject of trust evaluation, and a trust value evaluation method based on user type is designed; Finally, considering the dynamic nature of trust, a new trust update mechanism based on service quality is proposed by combining transaction time and transaction amount. The experimental results show that compared with the AARep model and PeerTrust model, this model not only has advantages in scenarios with a lower proportion of malicious nodes, but also improves interaction success rates by 12% and 18%, respectively, in harsh scenarios where the proportion of malicious nodes exceeds 72%. This model overcomes the low success rate of interaction between user nodes and service nodes in cloud environments and has strong resistance to malicious behavior.
Sensory Styling Design of Physiotherapy Beds based on BP Neural Network
Authors: Su Chen , Li Changjun , Jiang Yupeng , Li Xincan
Published: February 2025

There is a significant gap between the form of current physiotherapy beds and users' perceptual images. By employing techniques such as computer graphic design and logical operations, analyzing the mathematical relationship between user needs and design elements contributes to enhancing the scientific nature of product design and making the design process more rigorous. This paper, based on an analysis of the product image and design process, employs a comprehensive fuzzy evaluation method to identify representative perceptual vocabulary for physiotherapy beds. The KJ method and Delphi method are utilized to select necessary samples. A morphological analysis matrix is established using the morphological analysis method, and a comprehensive decision-making model for product design is constructed using a BP neural network on the MATLAB platform. Through training the BP neural network on physiotherapy bed products, it becomes possible to predict the perceptual evaluation of product design, achieving a quantification of the design. This provides valuable support for the appearance design of physiotherapy bed products and significantly enhances the efficiency of designers' work.
Enhancing Cloud Data Security Through an Encrypted and Efficient Connection Model based on Blockchain Technology
Authors: Sharma Sonali , Sharma Shilpi , Choudhury Tanupriya
Published: February 2025

Centralized file storage systems are widely used for sharing data and services, offering oversight capabilities to governing bodies. Despite their prevalence, these systems raise significant concerns about potential data misuse by authorities and control over internet information dissemination. The vulnerability of centralized systems has been highlighted by security breaches that exposed user data. To counteract these issues, researchers have proposed blockchain-based solutions for enhanced data protection. This research work highlights an innovative approach utilizing the services of Interplanetary File System (IPFS), a secure and encrypted connection framework accessible via web browsers that supports global data storage and distribution on a decentralized peer-to-peer network. This model ensures privacy, accuracy of information, and eliminates additional service fees or software requirements. However, even decentralized networks like IPFS have faced cyber threats compromising user data. In response to this challenge, the presented research outlines a model incorporating AES-256 encryption to protect files before uploading them onto IPFS nodes. Secure transmission is achieved through WebRTC technology which facilitates the exchange of encrypted file hashes and keys with recipients. The key takeaways from this study include an optimized method for file storage and distribution designed to thwart cyber-attacks targeting stored or shared files while also providing economic benefits by removing extra storage costs associated with large files in centralized systems. Overall, the research offers a robust solution aimed at safeguarding user privacy without sacrificing functionality or incurring high costs.
Quality Analysis and Prediction Method of Smart Energy Meter based on Data Fusion
Authors: Wang Siwei , Xiao Ji , Cheng Yingying , Su Yu , Chen Wenli
Published: February 2025

In order to study the quality analysis method of key links in smart energy meters, the author proposes a data fusion based quality analysis and prediction method for smart energy meters. This method is based on the relevant data of key links in the electric energy meter, and selects the data of the electric energy meter in research and development design, material procurement, production and manufacturing, acceptance testing, installation and operation, dismantling and scrapping as the sample data for model construction. The XGBoost algorithm classification method is used to establish an intelligent electric energy meter quality analysis model. Taking the dismantled electricity meter data of a certain power company as an example, this paper conducts modeling analysis and prediction of various quality issues of smart electricity meters, and conducts on-site verification. Based on the verification results, the model is continuously optimized. The results indicate that: The model was optimized using cross validation and grid search methods, and the final model achieved an accuracy rate of 0.74 and a recall rate of 0.82 on the validation set. This method can meet the actual needs of power grid business and objectively reflect the quality situation of key links in smart energy meters.
Research and Implementation of Campus Network Intrusion Detection System based on Data Mining and Image Processing
Authors: Zhang Zhe
Published: February 2025

In order to solve the problem of traditional intrusion detection system programs usually being manually written, with a large workload and certain limitations, the author proposes the research and implementation of a campus network intrusion detection system based on data mining and image processing. Its hardware components include a data warehouse, sensors, checkers, generators, etc. The software design includes a packet capture module, a data preprocessing module, and an event analyzer module. Experimental comparison with traditional methods. The experimental results show that the campus network intrusion detection system designed by the author is far superior to traditional system design in detecting intrusion behavior, approaching 100% infinitely, and has high effectiveness. The system has a certain degree of adaptive ability and can effectively detect external intrusions.
Research on Data Fusion Method of Mathematical Creativity Education based on AHP Hierarchical Analysis
Authors: Wang Pingping
Published: February 2025

Dempster-Shafer (DS) evidence theory is widely employed in the real world as a primary instrument for modeling uncertainty. However, when applying Dempster's combination rule, seemingly conflicting pieces of data could be merged to yield surprising results. There are a number of proposed scales for measuring the level of discrepancy between pieces of evidence. However, the presented methods only use a single metric to analyze the conflicting results. However, it is usually unwise to rely on a single criterion to measure the extent to which the facts conflict with one another. For the reason that flaws, differences, differences, and ambiguity all contribute to a higher level of conflict between the evidence. The objective of this study is to propose a novel data fusion method based on AHP for enhancing mathematical creativity education. This work stands out by effectively integrating multiple criteria to improve decision-making processes in educational settings. Given the efficacy of the approach proposed in this study in bringing together seemingly disparate data, we want to eventually extend its application to other forms of uncertainty theory, such as fuzzy set theory and imprecise probabilities. The concept of direct inquiry into the total ambiguity of evidence within the context of discernment will also be explored. Several criteria factors are used to determine the level of disagreement between the information presented here. A proposed analytic hierarchy technique uses multiple criteria to properly weight each piece of data. The initial stage is to assign a numerical value to each piece of evidence based on how well it satisfies each of the criteria. The criterion layer's covariance matrix can be derived by examining the relationship between the criteria's numerical values. After collecting data on each criterion's quantitative change, a fuzzy preference relation matrix can be built. The scheme layer makes use of a fuzzy preference relation matrix in place of a traditional pairwise comparison matrix. Each piece of evidence is given an overall weight based on its combined scheme weight and criteria weight. Two numerical experiments are offered to illustrate the effectiveness of the proposed method after the final weights have been applied to the primary evidence and the evidence has been combined using Dempster's rule. Results show that the proposed methodology outperforms alternative approaches to dealing with contradictory evidence discussed in the literature.
The Casting Process Optimization and Melt Flow Simulation based on Computer Simulation and Data Mining
Authors: Ding Yi , Song Xingang , Zhang Dongming
Published: February 2025

The flow state and velocity of magnesium alloy melt at different temperatures were studied by a contact test method. Using the SOLA-VOF finite difference method, the mathematical model of the three-dimensional flow field and temperature field in the flow field of magnesium alloy twin-roll casting-rolling molding stand plate was established. The liquid magnesium alloy melt takes the form of a convex arc and advances successively on the liquid metal surface. This is mainly due to the mass accumulation of the pyrolytic products in the liquid magnesium alloy melt. The filling time is shortened with the increase of pouring temperature and vacuum degree. In the filling stage, the filling rate showed periodic alternating changes.
Análisis y propuestas de mejora en la formación en higiene industrial en los másteres oficiales de prevención de riesgos laborales
Authors: Verdu-Andres Jorge
Published: February 2025

Introducción: Se cuantifica y analiza la carga lectiva global y en Higiene Industrial de los másteres universitarios oficiales en prevención de riesgos laborales ofertados en 2023/2024 en España.
Métodos: Se han consultado las webs del Ministerio de Universidades QEDU y RUCT, y las propias de los másteres oficiales. Se ha obtenido la titularidad pública o privada de la universidad, presencialidad o no de la docencia, créditos necesarios para obtener una o las tres especialidades, créditos cursados en higiene industrial.
Resultados: Se identificaron 53 titulaciones, de las que 29 acreditan las tres especialidades (higiene, seguridad y ergonomía/psicosociología), con menos de 80 créditos. Otras 6 no llegan a ese mínimo, por lo que dos tercios de las titulaciones no cumplen con los requisitos de duración del Real Decreto 39/1997 para certificar las tres especialidades. Para la formación en Higiene Industrial, 11 titulaciones (un quinto) imparten, al menos, 17 créditos entre la parte común y la especialidad, y cumplen con cursar un mínimo de 80 créditos para las tres especialidades.
Conclusiones: La mayoría de titulaciones no imparten las horas de formación requeridas para poder actuar como técnicos superiores en prevención de riesgos laborales en higiene industrial, de acuerdo a la legislación. Se propone una titulación de grado habilitante, actualizar los contenidos y recuperar la autorización de la autoridad laboral, que asegure el cumplimiento de la duración y contenidos del Real Decreto 39/1997, junto al de la ANECA en la verificación y reacreditación de la calidad de las titulaciones.
La distonía. Contingencia profesional en músicos. A propósito de un caso
Authors: Vicente Herrero María Teófila
Published: February 2025

La distonía es un trastorno motor que provoca contracciones involuntarias de los músculos por movimientos repetidos. Los músicos de viento y cuerda son especialmente vulnerables a esta enfermedad con afectación orofacial y del miembro superior dominante. Su origen es multifactorial, destacando como riesgos laborales los ergonómicos, psicosociales y organizacionales. La Legislación Española no contempla en el listado de enfermedades profesionales la distonía del músico. La determinación de contingencia resulta compleja para establecer los principios de causalidad y temporalidad exigidos por las Mutuas Colaboradoras con la Seguridad Social y por el Instituto Nacional de la Seguridad Social. El proceso acaba frecuentemente en los Tribunales de Justicia. La evidencia científica y la doctrina jurisprudencial aportan sustento documental que facilita la toma de decisiones y abre la puerta a una futura incorporación de la distonía de los músicos dentro del listado de enfermedades profesionales en nuestro país.
El entrenamiento funcional de alta intensidad HIFT una alternativa de intervención en ambientes laborales
Authors: Zapata-Valencia Cristhian Mauricio , García Yerena Carlos Enrique , Bustos-Viviescas Brian Johan
Published: February 2025

La versatilidad y la mínima necesidad de equipamiento del HIFT lo hacen ideal para entornos laborales en los que puede implementarse sin interrupciones significativas en la rutina diaria. Por lo tanto, se concluye que, hasta la fecha, no se han realizado estudios para evaluar los efectos del HIFT sobre los marcadores de salud o la aptitud física en la población laboral administrativa, lo que representa una importante oportunidad para la investigación y la acción preventiva en este ámbito.
Evaluación de la exposición inhalatoria a agentes químicos en un laboratorio de física mediante el método Coshh Essentials
Authors: Cañón Lara Paola Astrid , Lozano Piedrahita Carlos Julio
Published: February 2025

La evaluación de riesgos químicos es crucial para establecer acciones que eliminen, reduzcan o controlen el riesgo de enfermedades laborales. Tradicionalmente, se realiza mediante métodos higiénicos cuantitativos y costos elevados para las organizaciones. La metodología COSHH Essentials es una buena alternativa, sencilla y económica, que se utilizó en un laboratorio de física en Colombia con el objetivo de evaluar del riesgo inhalatorio a sustancias químicas. Se revisó la peligrosidad específica de una serie de agentes químicos y el análisis de la exposición potencial, volatilidad o pulverulencia y la cantidad utilizada, como una primera aproximación para la evaluación del riesgo químico. Se establecieron cuatro niveles de riesgo permitiendo definir las acciones para mantener la exposición en niveles adecuados para evitar el riesgo de enfermedades laborales por inhalación. La metodología permite su aplicación en otros laboratorios, su enfoque cualitativo generó una valoración rápida y sistemática del riesgo potencial, y a coste reducido.
Riesgo durante la Lactancia Natural en Trabajadoras Sanitarias … ¿conceden los Tribunales la prestación?
Authors: González Cáceres Ana María , Rosas Molina María José , Mateo García Marco Antonio , Lang-Lenton Ramírez Luis , Suárez Melián Iván , González Cáceres Elda María
Published: February 2025

La OMS y la Asociación Española de Pediatría (AEP) recomiendan un inicio precoz de la lactancia materna y su mantenimiento el mayor tiempo posible. La prestación por riesgo durante la lactancia natural se introduce en la legislación española con la Ley Orgánica 3/2007 de 22 de marzo y consigue el desarrollo reglamentario en el Real Decreto 295/2009, de 6 de marzo.
Se utiliza el buscador del Centro de Documentación Judicial CENDOJ con las palabras claves: Riesgo durante la lactancia natural y Sanidad.
Se obtienen 10 resultados de los que se excluyen 5 por no corresponder con los criterios de búsqueda.
Se observa que la mayoría de las sentencias estiman las demandas de las trabajadoras. Influye la existencia de una evaluación de riesgos del puesto de trabajo específica para la lactancia. Existe discrepancia entre lo que promulga la OMS y la AEP y los derechos reconocidos en la legislación laboral española.
Relación entre las condiciones laborales, trastornos musculoesqueléticos, y riesgos psicosociales: El papel mediador de la actividad física en los trabajadores
Authors: Bustos-Viviescas Brian Johan , García Yerena Carlos Enrique , Villamizar Navarro Amalia
Published: February 2025

La revisión de los estudios presentados subraya la importancia de abordar no solo los aspectos físicos de la carga laboral, sino también los factores psicosociales y el papel de la actividad física en la prevención y mitigación de los trastornos musculoesqueléticos. De esta manera, es crucial que las organizaciones y autoridades competentes prioricen la implementación de políticas integrales y enfoques preventivos que consideren la ergonomía, la gestión del estrés y la promoción de un estilo de vida saludable en el lugar de trabajo. Hacerlo contribuirá no solo a mejorar el bienestar de los trabajadores, sino también a reducir la incidencia de trastornos relacionados con el trabajo, y, así fortalecer el compromiso laboral.
Riesgo al levantar cargas: mucho más que biomecánica. Investigación con metodología mixta en una pequeña empresa constructora de Colombia
Authors: Gómez salazar Lessby , Sibaja Terán Beatriz , Ordóñez Hernndez Cecilia Andrea , Martinez älvarez Luz América
Published: February 2025

Objetivo: Evaluar integralmente el riesgo de trastornos musculoesqueléticos asociado al levantamiento de cargas relacionado con los factores biomecánicos en el trabajo en la construcción, y analizar las percepciones y estrategias de afrontamiento de los/as trabajadores/as expuestos. 
Métodos: Estudio transversal con un enfoque mixto, cuantitativo y cualitativo. La fase cuantitativa consistió en una evaluación de 8 tareas comunes en la construcción mediante los métodos NIOSH y OWAS. La fase cualitativa incluyó entrevistas en profundidad sobre la percepción del riesgo y formas de afrontamiento, y se analizó el contenido temático. 
Resultados: El 62,5% de las tareas evaluadas presentaron niveles de riesgo alto a moderado de lesión musculoesquelética, siendo el paleo y levantamiento de bultos de cemento las de mayor riesgo. Las entrevistas revelaron normalización del riesgo, influencia de factores socioculturales y económicos (precariedad laboral) en la percepción y manejo del riesgo. Se identificaron factores concomitantes para el análisis, como la baja experiencia laboral, el rol de la mujer en el sector, y el estatus migratorio de los trabajadores. Se generó un modelo integrador para el análisis del riesgo.
Conclusiones: El riesgo asociado al levantamiento de cargas en construcción trasciende los aspectos biomecánicos. Factores socioeconómicos, psicosociales, de género y culturales afectan la forma de afrontar el riesgo. Sin mejoras en estos aspectos, los ajustes en los puestos de trabajo no serán suficientes para mitigar el impacto sobre la salud de los/as trabajadores/as y las empresas.
AI – Here, There and Everywhere
Authors: Tyler Neil
Published: February 2025

CES 2025 didn’t disappoint with plenty of innovation and announcements, but artificial intelligence continued to make the news.
View from The Top
Authors: Fanning Paul
Published: February 2025

With all the obstacles facing UK manufacturing at the moment, nothing is dimming Stephen Phipson’s belief in the ability and resilience of the sector.
Navigating Cobot Safety
Authors: Androsiuk Matt
Published: February 2025

The BSI has recently reviewed the changes to the standards ahead of them being released later this year. What will this change mean for cobot users and integrators?
Strengthening Supplier Relationships
Authors: Francis TY
Published: February 2025

Managing risks, especially within third-party and supplier relationships, is a vital component of a strong supply chain strategy.
Finite groups with consecutive character codegrees
Authors: Song Xueling , Shang Tiantian
Published: February 2025

Let $G$ be a finite group and $\mathrm{Irr}(G)$ be the set of irreducible characters of $G$. The codegree of an irreducible character $\chi$ of the group $G$ is defined as $\mathrm{cod}(\chi)=|G:\mathrm{ker}(\chi)|/\chi(1)$. In this paper, we consider the finite group $G$ whose all irreducible character codegrees are consecutive integers $1,2,3,...,k-1,k$. We prove that $k\leq 3$ and $G$ is an elementary abelian group or a Frobenius group.
Prevalence of calcaneal spur among foot and ankle patients at the Cape Coast Teaching Hospital, Ghana
Authors: Fiagbedzi Emmanuel , Ofori Nana , Amlalo Jeffrey Gameli
Published: February 2025

BACKGROUND A calcaneal spur is a bony protrusion that grows from the calcaneus. This study aimed to estimate the prevalence of calcaneal spurs and associated risk variables (age, gender, and type) in patients undergoing foot and ankle X-ray examinations at the Cape Coast Teaching Hospital.
METHODS A retrospective cross-sectional approach and non-probability purposive sampling were used to analyze radiographic reports. A total of 323 radiographic reports from patients undergoing ankle and foot X-ray examinations between July 2020 and July 2023 were selected from 1,690 radiographs and analyzed using Microsoft Excel 2019 and SPSS software version 26.0.
RESULTS The overall prevalence was 34.7% (112/323), with 112 cases indicating calcaneal spurs. Of the patients, 72 (64.3%) were females. Among the cases, 53 (47.3%) were plantar spurs, 40 (35.7%) were dorsal spurs, and 19 (17.0%) exhibited both types. The highest prevalence was found in the 51–60 age group, representing 30 (26.8%) cases. Age was found to have a significant association with calcaneal spur development (p = 0.044).
CONCLUSIONS Both plantar and dorsal calcaneal spurs were significantly associated with age, with the 51–60 age group at higher risk.
Natural remedies in burn care: a systematic review and network meta-analysis
Authors: Ismail Muhammad Azri , Tanjaya Krisanto , Wruhastanti Gisella Sekar , Siswanto Yudi
Published: February 2025

BACKGROUND Burn injuries are a global public health issue that impact healing time and cause complications. While silver sulfadiazine (SSD) cream is commonly used for treatment, research indicates that SSD can hinder the wound healing process. Natural alternatives like Aloe vera, honey, and amniotic membranes have shown promise in promoting wound healing. This study aimed to evaluate their efficacy by their wound healing time and infection rate.
METHODS 3 independent reviewers conducted a literature search across 6 databases (Cochrane Central Register of Controlled Trials, PubMed, ScienceDirect, Taylor & Francis, Wiley, and ProQuest). Quality assessment was conducted using the Cochrane Risk of Bias 2 tool, while network meta-analysis was performed using the netmeta package in R. The variable in this study is the average time to burn wound healing and infection occurrence by analyzing MD data or OR of each intervention, with 95% CI to calculate the efficacy.
RESULTS A total of 3,434 patients from 37 studies were included. In the analysis of 26 studies comparing the healing time to SSD, A. vera has the best efficacy (MD: −4.75; 95% CI: −8.67 to −0.86), followed by amniotic membrane (MD: −4.71; 95% CI: −7.45 to −1.97), and honey (MD: −4.25; 95% CI: −6.76 to −1.73). Meanwhile, the occurrence of infection analysis in burn wounds across 24 studies highlighted that honey has the lowest infection rate (OR: 0.09; 95% CI: 0.04 to 0.23) and was the only statistically significant finding when compared to SSD.
CONCLUSIONS Aloe vera and amniotic membrane are effective for wound healing, while honey is particularly effective in preventing wound infection in patients with burn injuries.