bluuebunny/crossref_metadata_2025 huggingface dataset:
Inflammation and Epigenetic Aging Are Largely Independent Markers of Biological Aging and Mortality
Authors: Cribb Lachlan , Hodge Allison M , Yu Chenglong , Li Sherly X , English Dallas R , Makalic Enes , Southey Melissa C , Milne Roger L , Giles Graham G , Dugué Pierre-Antoine
Published: August 2022

Limited evidence exists on the link between inflammation and epigenetic aging. We aimed to (a) assess the cross-sectional and prospective associations of 22 inflammation-related plasma markers and a signature of inflammaging with epigenetic aging and (b) determine whether epigenetic aging and inflammaging are independently associated with mortality. Blood samples from 940 participants in the Melbourne Collaborative Cohort Study collected at baseline (1990–1994) and follow-up (2003–2007) were assayed for DNA methylation and 22 inflammation-related markers, including well-established markers (eg, interleukins and C-reactive protein) and metabolites of the tryptophan–kynurenine pathway. Four measures of epigenetic aging (PhenoAge, GrimAge, DunedinPoAm, and Zhang) and a signature of inflammaging were considered, adjusted for age, and transformed to Z scores. Associations were assessed using linear regression, and mortality hazard ratios (HR) and 95% confidence intervals (95% CI) were estimated using Cox regression. Cross-sectionally, most inflammation-related markers were associated with epigenetic aging measures, although with generally modest effect sizes (regression coefficients per SD ≤ 0.26) and explaining altogether between 1% and 11% of their variation. Prospectively, baseline inflammation-related markers were not, or only weakly, associated with epigenetic aging after 11 years of follow-up. Epigenetic aging and inflammaging were strongly and independently associated with mortality, for example, inflammaging: HR = 1.41, 95% CI = 1.27–1.56, p = 2 × 10−10, which was only slightly attenuated after adjustment for 4 epigenetic aging measures: HR = 1.35, 95% CI = 1.22–1.51, p = 7 × 10−9). Although cross-sectionally associated with epigenetic aging, inflammation-related markers accounted for a modest proportion of its variation. Inflammaging and epigenetic aging are essentially nonoverlapping markers of biological aging and may be used jointly to predict mortality.
The Effects of Repetitive Transcranial Magnetic Stimulation on Standing Balance and Walking in Older Adults with Age-related Neurological Disorders: A Systematic Review and Meta-analysis
Authors: Zhou Jun , Chen Yan , Gin Trenton , Bao Dapeng , Zhou Junhong
Published: August 2022

Background

Considerable evidence showed that repetitive transcranial magnetic stimulation (rTMS) can improve standing balance and walking performance in older adults with age-related neurological disorders. We here thus completed a systematic review and meta-analysis to quantitatively examine such benefits of rTMS.

Methods

A search strategy based on the PICOS principle was used to obtain the literature in 4 databases. The screening and assessments of quality and risk of bias in the included studies were independently completed by 2 researchers. Outcomes included scales related to standing balance, Timed Up and Go (TUG) time, and walking speed/time/distance.

Results

Twenty-three studies consisting of 532 participants were included, and the meta-analysis was completed on 21 of these studies. The study quality was good. Compared to control, rTMS induced both short-term (≤3 days after last intervention session) and long-term (≥1 month following last intervention session) significant improvements in balance scales (eg, Berg Balance Scale), TUG time, and walking speed/time/distance (short-term: standardized mean difference [SMD] = 0.26–0.34, 95% confidence interval [CI] = 0.05–0.62; long-term: SMD = 0.40–0.47, 95% CI = 0.04–0.79) for both PD and stroke cohorts. Subgroup analyses suggested that greater than 9 sessions of high-frequency rTMS targeting primary motor cortex with greater than 3 000 pulses/wk can maximize such benefits. Only a few mild-to-moderate adverse events/side effects were reported, which were similar between rTMS and control group.

Conclusion

The results suggest that rTMS holds promise to improve balance and walking performance in older adults with age-related neurological disorders. Future studies with more rigorous design are needed to confirm the observations in this work.
Automated Vehicles for People With Dementia: A “Tremendous Potential” That “Has Ways to go”―Reports of a Qualitative Study
Authors: Haghzare Shabnam , Stasiulis Elaine , Delfi Ghazaleh , Mohamud Hodan , Rapoport Mark J , Naglie Gary , Mihailidis Alex , Campos Jennifer L
Published: August 2022

Background and Objectives

The prospect of automated vehicles (AVs) has generated excitement among the public and the research community about their potential to sustain the safe driving of people with dementia. However, no study to date has assessed the views of people with dementia on whether AVs may address their driving challenges.

Research Design and Methods

This mixed-methods study included two phases, completed by nine people with dementia. Phase I included questionnaires and individual semistructured interviews on attitudes toward using different types of AVs (i.e., partially or fully automated). Interpretative phenomenological analysis was used to assess participants’ underlying reasons for and against AV use. The participants’ identified reasons against AV use informed the focus group discussions in Phase II, where participants were asked to reflect on potential means of overcoming their hesitancies regarding AV use.

Results

The results showed that people with dementia might place higher levels of trust in fully automated compared to partially automated AVs. In addition, while people with dementia expressed multiple incentives to use AVs (e.g., regaining personal freedom), they also had hesitations about AV use. These hesitancies were based on their perceptions about AVs (e.g., cost), their own abilities (i.e., potential challenges operating an AV), and driving conditions (i.e., risk of driving in adverse weather conditions).

Discussion and Implications

The findings of this study can help promote the research community’s appreciation and understanding of the significant potential of AVs for people with dementia while elucidating the potential barriers of AV use by people with dementia.
10. Human Security
Authors: Persaud Randolph B.
Published: August 2022

This chapter examines the concept of human security. It does so in descriptive, analytical, and empirical terms, drawing on both the scholarly and policy-relevant literatures. The chapter describes the development of human security, with references to the academic literature where necessary. Accordingly, the emergence, contribution, and impact of the most important drivers of human security, especially in institutional terms, are examined. These include the 1994 UNDP Human Development Report (HDR), the Commission for Human Security, the International Commission on Intervention and State Sovereignty, the Millennium Development Goals, and the International Criminal Court. The chapter takes up a recurring question about the newness of human security by looking at its intellectual and institutional genealogy. The chapter provides a detailed overview of the most trenchant critiques of human security. These critiques are placed into the following categories—too broad to be useful; national interest and co-optation; reformist tool of global capitalism; and neo-colonialism.
A social scientific self-reflection of co-developing an acoustic stock sampling method in the Bay of Biscay
Authors: Köpsel Vera
Published: August 2022

This story from the frontlines reflects on the process of engaging with artisanal fishers in the Bay of Biscay (France) for co-developing a new method for acoustic fish stock sampling. The case discussed here was set in the frame of the EU H2020 project PANDORA, starting in May 2018 and ending in April 2022. From the perspective of a social scientifically trained human geographer and based on a dialogue with her colleagues in France, the author reflects on the motivations, expectations, and goals of the researchers of the engagement process and contrasts them with the actual outcomes. As the backdrop of this reflection serve theoretical considerations about the importance of researchers’ awareness of their own role and motivations in engagement processes and the (hidden) agendas that all parties bring to the table, as well as some thoughts about the relevance we attribute to scientific and experiential knowledge. In particular, this article highlights four aspects that importantly contributed to the success of the co-development activities: a joint problem definition, a certain co-dependency between researchers and stakeholders, sound project and budget planning, and the motivations and expectations of the “engagers”—those researchers who initiate and facilitate engagement processes.
Determination of 19 Fragrance Allergens in Paper Household Goods by Solid-Liquid Extraction-Dispersive Liquid-Liquid Microextraction-GC-MS
Authors: Yi Zonghui , Chen Jing , Yong Li , Zhou Chen , Yuan Yue , Li Yongxin
Published: August 2022

Background

Fragrance allergens (FAs) refer to these volatile or semi-volatile fragrance compounds that can induce sensitization, and they are widely used in household goods.

Objective

In this work, a method combining solid-liquid extraction (SLE) and dispersive liquid-liquid microextraction (DLLME) with gas chromatography-mass spectrometry (GC-MS) has been developed and applied in the analysis of 19 FAs (including hydrocarbons, alcohols, aldehydes, esters, and phenols) in paper household goods.

Method

The samples (infant or personal paper hygiene products) were cut into small pieces and underwent SLE with methanol as solvent. The supernatant was taken, and ultrapure water, sodium chloride, and trichloromethane (extractant) were added, which was mixed with vortex. After centrifugation, the bottom chloroform layer was taken for GC-MS detection.

Results

Under optimized conditions, a good linearity was achieved (r ≥ 0.9985) in the range of 0.01–128.0 mg/kg with relative standard deviations lower than 15%. The method showed limits of detection (LODs) within the range of 0.96–12.0 µg/kg and recoveries from 70.6% to 128.9%, except furfuryl alcohol with low recoveries (53.8–64.6%). Twenty kinds of paper household goods samples were analyzed by this method; nine FAs were detected. The linalool detected in one sample was more than 10 mg/kg, and the contents of other analytes in this sample and all analytes in other samples were less than 10 mg/kg.

Conclusions

The performance evaluation of the method met the requirements of the analysis of trace components. The established method was successfully applied to the detection of FAs in paper household goods samples. The proposed method could provide a basis for the establishment of relevant detection standards in the future.

Highlights

The LODs were found between 0.96 and 12.0 µg/kg. A simple, economical, and sensitive method was established for the determination of 19 FAs in paper household goods.
Development and Validation of an UHPLC–MS/MS Method for the Determination of 32 Pyrrolizidine Alkaloids in Chinese Wild Honey
Authors: Wu Haiping , Fan Dingyan , Cheng Jiangchuang
Published: August 2022

Background

Studies on pyrrolizidine alkaloid (PA) contamination in honey produced in China are scarce. Previously reported HPLC–MS/MS methods for the determination of PAs in honey often suffer from insufficient separation and uncertainties in PA isomers.

Objective

To develop and validate an Ultra-HPLC (UHPLC)–MS/MS method for baseline separation of PA isomers towards precise determination of 32 PAs in Chinese wild honey.

Methods

PAs were extracted from honey samples and separated on an ACQUITY BEH C18 (2.1 mm × 100 mm, 1.7 µm) column with (A) 0.1% formic acid aqueous solution containing 5 mM ammonium acetate and (B) methanol as mobile phase. The column temperature was maintained at 30°C, and flow rate was 0.3 mL/min. Detection was performed by tandem mass spectrometry. The total run time was reduced to 18 min.

Results

Thirty-one of 32 PAs were baseline separated efficiently within 18 min. The LOD and LOQ were 0.06–0.25 µg/kg and 0.22–0.82 µg/kg, respectively, except for that of clivorine, for which LOD and LOQ were 2.03 and 6.78 µg/kg, respectively. The average recoveries ranged between 66.3 and 95.1% and the average RSDs were 3.2 to 8%. The established method was used to analyze PAs in 22 types of Chinese wild honey, and the predominant PAs found in these honey samples were intermedine and lycopsamine.

Conclusion

A high-throughput method for the determination of isomeric PAs in honey was developed and validated. Five of the 22 types of Chinese wild honey were contaminated with PAs concentrations of 2.2–207.0 µg/kg.

Highlights

A new method capable of monitoring more PAs and providing better separation than previously reported protocols for the determination of multiclass PAs in honey is established.
Toxicological Investigation of a Case Series Involving the Synthetic Cathinone α-Pyrrolidinohexiophenone (α-PHP) and Identification of Phase I and II Metabolites in Human Urine
Authors: Grapp Marcel , Kaufmann Christoph , Schwelm Hannes M , Neukamm Merja A
Published: August 2022

α-Pyrrolidinohexiophenone (α-PHP) is a derivative of the class of α-pyrrolidinophenones, a subgroup of synthetic cathinones. These substances are the second most abused drugs of new psychoactive substances. Here, we report the toxicological investigation of a series of 29 authentic forensic and clinical cases with analytically confirmed intake of α-PHP including two cases of drug testing in newborns using meconium. The age range of subjects where serum samples were available was 23–51 years (median 39.5), and 90% were male. Serum α-PHP concentrations, determined by a validated LC–MS-MS method, showed a high variability ranging from 1 to 83 ng/mL (mean, 40 ng/mL; median, 36 ng/mL). Comprehensive toxicological analysis revealed co-consumption of other psychotropic drugs in almost all cases with frequent occurrence of opiates (60%), benzodiazepines (35%), cannabinoids (30%), and cocaine (20%). Hence, forensic and clinical symptoms like aggressive behavior, sweating, delayed physical response, and impaired balance could not be explained by the abuse of α-PHP alone but rather by poly-intoxications. Liquid chromatography-quadrupole time-of-flight mass spectrometry and gas chromatography-mass spectrometry were used to investigate the metabolism of α-PHP in vivo using authentic human urine samples. Altogether, 11 phase I metabolites and 5 phase II glucuronides could be identified by this approach. Apart from the parent drug, most abundant findings in urine were the metabolites dihydroxy-pyrrolidinyl-α-PHP and dihydro-α-PHP and, to a lesser extent, 2ʹ-oxo-dihydro-α-PHP and 2ʹ-oxo-α-PHP. Monitoring of these metabolites along with the parent drug in forensic and clinical toxicology could unambiguously prove the abuse of the novel designer drug α-PHP.
Examples of Risk Tools for Pests in Peanut (Arachis hypogaea) Developed for Five Countries Using Microsoft Excel
Authors: Jordan David L , Buol Greg S , Brandenburg Rick L , Reisig Dominic , Nboyine Jerry , Abudulai Mumuni , Oteng-Frimpong Richard , Brandford Mochiah Moses , Asibuo James Y , Arthur Stephen , Akromah Richard , Mhango Wezi , Chintu Justus , Morichetti Sergio , Paredes Juan A , Monguillot Joaquin H , Singh Jadon Kuldeep , Shew Barbara B , Jasrotia Poonam , Thirumalaisamy P P , Harish G , Holajjer Prasanna , Maheshala Nataraja , MacDonald Greg , Hoisington David , Rhoads James
Published: August 2022

Suppressing pest populations below economically-damaging levels is an important element of sustainable peanut (Arachis hypogaea L.) production. Peanut farmers and their advisors often approach pest management with similar goals regardless of where they are located. Anticipating pest outbreaks using field history and monitoring pest populations are fundamental to protecting yield and financial investment. Microsoft Excel was used to develop individual risk indices for pests, a composite assessment of risk, and costs of risk mitigation practices for peanut in Argentina, Ghana, India, Malawi, and North Carolina (NC) in the United States (US). Depending on pests and resources available to manage pests, risk tools vary considerably, especially in the context of other crops that are grown in sequence with peanut, cultivars, and chemical inputs. In Argentina, India, and the US where more tools (e.g., mechanization and pesticides) are available, risk indices for a wide array of economically important pests were developed with the assumption that reducing risk to those pests likely will impact peanut yield in a positive manner. In Ghana and Malawi where fewer management tools are available, risks to yield and aflatoxin contamination are presented without risk indices for individual pests. The Microsoft Excel platform can be updated as new and additional information on effectiveness of management practices becomes apparent. Tools can be developed using this platform that are appropriate for their geography, environment, cropping systems, and pest complexes and management inputs that are available. In this article we present examples for the risk tool for each country.
Validity and safety of laparoscopic gastrectomy with D1+ lymphadenectomy for very elderly advanced gastric cancer patients; retrospective cohort study
Authors: Fujimoto Daisuke , Taniguchi Keizo , Takashima Junpei , Miura Fumihiko , Kobayashi Hirotoshi
Published: August 2022

Background

It remains unclear whether laparoscopic gastrectomy with optimal lymphadenectomy is appropriate for very elderly patients with advanced gastric cancer. This study aimed to assess the validity of laparoscopic gastrectomy with D1+ lymphadenectomy performed for advanced gastric cancer in patients aged 80 years or more.

Methods

Included in this retrospective study were 122 patients who underwent curative laparoscopic gastrectomy for advanced gastric cancer between 2013 and 2018. All patients over 80 years old underwent laparoscopic gastrectomy with D1+ lymphadenectomy. We divided patients by age between those who were very elderly (age ≥ 80 years; very elderly group [n = 57]) and those who were non-very elderly (age < 80 years; control group [n = 65]), and we compared patient and clinicopathological characteristics, intraoperative outcomes, and short- and long-term outcomes between the two groups. We also performed multivariate analyses to identify predictors of postoperative prognosis.

Results

Eastern Cooperative Oncology Group Performance Status of grade 2 or higher and mean Charlson comorbidity index score and body mass index were significantly different between the very elderly group and the control group. Adjuvant chemotherapy was used in relatively few very elderly group patients. Operation time, blood loss volume, and postoperative morbidity and mortality did not differ between the two groups. The overall survival and disease-specific survival rate of very elderly group patients with the Charlson comorbidity index score of <3 was not significantly different from that of the control group patients.

Conclusion

The treatment of advanced gastric cancer by laparoscopic gastrectomy with D1+ lymphadenectomy to be both safe and effective in the very elderly group patients with the Charlson comorbidity index score of <3.
Two New Species and New Records of Sepsidae from the Brazilian Amazon
Authors: Nascimento Raimundo F O , Esposito Maria C , Carvalho-Filho Fernando S
Published: August 2022

The dipteran fauna from the Brazilian Amazon remains poorly known, including that of forensic interest, such as the Sepsidae. The sepsid fauna of two secondary forests in the eastern Amazon was surveyed utilizing rotting bovine lung and feces (humans, bovines, and monkeys). We obtained 17 sespid species in six genera, most of them on bovine dung and rotting bovine lung. Two new species are described herein: Archisepsis bosque sp. nov. and Archisepsis verae sp. nov. The genus Palaeosepsis Duda, 1926 and the species Archisepsis polychaeta (Ozerov, 1993), Archisepsis diversiformis (Ozerov, 1993), Microsepsis mitis (Curran, 1927), Meropliosepsis sexsetosa Duda, 1926, and Palaeosepsis cf. golovastikOzerov, 2004 are newly recorded from the Brazilian Amazon.
Severity of Illness Caused by Severe Acute Respiratory Syndrome Coronavirus 2 Variants of Concern in Children: A Single-Center Retrospective Cohort Study
Authors: Edward Priya R , Lorenzo-Redondo Ramon , Reyna Megan E , Simons Lacy M , Hultquist Judd F , Patel Ami B , Ozer Egon A , Muller William J , Heald-Sargent Taylor , McHugh Matthew , Dean Taylor , Dalal Raj M , John Jordan , Manz Shannon C , Kociolek Larry K
Published: August 2022

Background

Recent COVID-19 surges are attributed to emergence of more transmissible SARS-CoV-2 variants of concern (VOCs). The relative severity of VOCs in children is unknown.

Methods

We performed a single-center retrospective cohort study of children ≤18 years old diagnosed with COVID-19 from October 2020–February 2022 and whose SARS-CoV-2 isolate underwent Illumina sequencing. We measured the frequency of five markers of COVID-19 severity. Logistic regression models were fitted to estimate the odds of each severity marker with each VOC.

Results

Among 714 children, 471 (66.0%) were infected with a VOC: 96 (13.4%) alpha, 38 (5.3%) gamma, 119 (16.7%) delta, and 215 (30.1%) omicron. High-risk medical conditions and increasing age were independently associated with COVID-19 severity. After adjusting for age, race, ethnicity, high-risk medical conditions, and COVID-19 community incidence, neither alpha, delta, nor omicron was associated with severe COVID-19. Gamma was independently associated with hospitalization (OR 6.7, 95% CI 2.0–22.1); pharmacologic treatment (OR 5.7, 95% CI 1.2–26.8); respiratory support (OR 11.9, 95% CI 2.7–62.4); and severe disease per the WHO Clinical Progression Scale (OR 11.7, 95% CI 2.1–90.5). Upon subgroup analyses, omicron was independently associated with ICU admission and severe disease per the WHO Clinical Progression Scale in children without SARS-CoV-2 immunization or prior COVID-19 infection.

Conclusions

Compared to non-VOC COVID-19, the gamma VOC was independently associated with increased COVID-19 severity, as was omicron in children without SARS-CoV-2 immunization or prior COVID-19 infection. SARS-CoV-2 vaccination and prior COVID-19 prevented severe outcomes during the omicron surge.
A solitary giant neurofibroma of the left thigh: a case report
Authors: Okamoto Maki , Ueda Takayuki , Fukui Michika , Mitsui Toshihito , Masuoka Hiromu , Hihara Masakatsu , Kakudo Natsuko
Published: August 2022

A neurofibroma not associated with neurofibromatosis type 1 is termed solitary neurofibroma. A solitary giant neurofibroma of the thigh is an extremely rare tumor. A 44-year-old woman presented to us with a well-defined swelling on her left thigh for 10 years. On the basis of magnetic resonance image finding, we diagnosed the tumor as a neurofibroma. We excised the tumor and the pathological findings established the diagnosis of neurofibroma. There was no recurrence 8-months after surgery.
A versatile Cas12k-based genetic engineering toolkit (C12KGET) for metabolic engineering in genetic manipulation-deprived strains
Authors: Cui Yali , Dong Huina , Tong Baisong , Wang Huiying , Chen Xipeng , Liu Guangqing , Zhang Dawei
Published: August 2022

The genetic modification of microorganisms is conducive to the selection of high-yield producers of high-value-added chemicals, but a lack of genetic tools hinders the industrialization of most wild species. Therefore, it is crucial to develop host-independent gene editing tools that can be used for genetic manipulation-deprived strains. The Tn7-like transposon from Scytonema hofmanni has been shown to mediate homologous recombination-independent genomic integration after heterologous expression in Escherichia coli, but the integration efficiency of heterologous sequences larger than 5 kb remains suboptimal. Here, we constructed a versatile Cas12k-based genetic engineering toolkit (C12KGET) that can achieve genomic integration of fragments up to 10 kb in size with up to 100% efficiency in challenging strains. Using C12KGET, we achieved the first example of highly efficient genome editing in Sinorhizobium meliloti, which successfully solved the problem that industrial strains are difficult to genetically modify, and increased vitamin B12 production by 25%. In addition, Cas12k can be directly used for transcriptional regulation of genes with up to 92% efficiency due to its naturally inactivated nuclease domain. The C12KGET established in this study is a versatile and efficient marker-free tool for gene integration as well as transcriptional regulation that can be used for challenging strains with underdeveloped genetic toolkits.
Results of NC-6300 (Nanoparticle Epirubicin) in an Expansion Cohort of Patients with Angiosarcoma
Authors: Riedel Richard F , Chua Victoria , Moradkhani Ania , Krkyan Natalie , Ahari Amir , Osada Atsushi , Chawla Sant P
Published: August 2022

Background

NC-6300 is a novel epirubicin (EPI) drug conjugated polymeric micelle developed using cutting-edge micellar nanoparticle technology. The nanoparticle epirubicin conjugates EPI to a polymer via a pH-sensitive linker which enables the selective EPI release into tumor. Tumor activity was observed in a monotherapy phase Ib trial, where two of two patients with angiosarcoma achieved a partial response. To further explore the activity of NC-6300 in angiosarcoma, an expansion cohort was undertaken.

Methods

Ten patients with angiosarcoma were enrolled in the expansion cohort. Patients were dosed using the recommended dose of 150 mg/m2 intravenously (IV) once every 3 weeks. The primary endpoint was progression-free survival.

Results

The most common adverse events (AEs) of any grade, regardless of the causal relationship with NC-6300, were neutropenia (90%), fatigue, and thrombocytopenia (60% each) and nausea (50%). The most common grades 3 and 4 AEs were neutropenia (80%), thrombocytopenia (40%), and anemia and leukopenia (20% each). The median progression-free survival (mPFS) for all subjects was 5.4 months. The mPFS was 3.8 months in subjects with prior anthracycline treatment and 8.2 months in subjects without prior anthracycline treatment.

Conclusion

NC-6300 was well tolerated, showing promising activity in angiosarcoma patients without prior anthracycline treatment. NC-6300 warrants further investigation (ClinicalTrials.gov Identifier: NCT03168061).
Arc–Backarc Exchange Along the Tonga–Lau System: Constraints From Volatile Elements
Authors: Cooper Lauren , Plank Terry , Arculus Richard , Hauri Erik , Kelley Katherine A
Published: August 2022

Analyses of olivine-, pyroxene- and plagioclase-hosted melt (now preserved as glass) inclusions (MI) in submarine glasses and subaerial scoria from seven volcanoes along the volcanic front of the Tonga arc provide the first comprehensive dataset including volatile contents (H2O, CO2, S, Cl and F) for this arc. Maximum water contents at each volcano are typical (3–5 wt %) of other arc volcanoes worldwide, and within each volcano, water generally correlates with sulfur, consistent with degassing but not diffusive re-equilibration. The Tonga arc is notable for the eruption of magmas sourced from strongly depleted upper mantle, including boninites in the northern half of the active arc. A key question has been whether such boninites are derived from high degrees of melting actively occurring under the arc, driven by high mantle temperatures and water contents, or from high integrated degrees of melting including melting of depleted mantle in the backarc. This study supports the latter view, based on sub-arc mantle melt fractions of 17–23%, calculated from primary melt water contents and mantle-melt thermobarometry. Such fractions are not high enough to generate boninites from a typical, fertile mantle source in a single melting stage, and melt fractions do not increase north of 22°S, where the boninitic magmas appear. Instead, the northern Tonga arc boninites reflect high cumulative degrees of melting (>30%, with respect to fertile mantle) and occur along the volcanic front where adjacent backarc spreading is fast, proximal and mature. Slab tracers such as the Ba/La ratio peak at around 20–21°S, in the central part of the Tonga arc. A Ba/La peak also appears at about the same latitude in the Lau backarc basin. This peak is consistent with the coolest slab temperatures beneath the arc and backarc at this latitude, as the slab warms to the north due to an increase in mantle potential temperature, and to the south due to less heat extraction from melting. A new concept developed here is cooling of the mantle wedge by melting, due to the supply of the heat of fusion and melt removal. Such a process can cool the mantle by more than 100 degrees, and thus affect slab heating as well. We find a critical distance of slab influence in the Lau spreading centers; back-arc magmas erupted >70 km from the arc are >210 km above the slab, beyond the point of slab dehydration, and show no enrichment in Ba/La. The coupled dynamics of the Tonga arc-Lau basin are rich in their connections, and demonstrate how melting processes beneath the back-arc and arc can affect slab processes, which in turn can affect the composition of fluids that feed the arc and backarc.
Petrology and P-T-t Path of Huangyuan Group and Maxianshan Group in the Central Qilian Block, NW China: Implications for Tectonic Evolution of the Proto-Tethys Ocean
Authors: Li Yilong , Xiang Hua , Zheng Jianping , Qiu Huaning , Bai Xiujuan , Brouwer Fraukje M.
Published: August 2022

The Qilian orogen marks the northern boundary of the Proto-Tethys Ocean and consists of the North Qilian belt, the Central Qilian block and the South Qilian belt. The metamorphic P–T–t path of the Central Qilian block and the tectonothermal processes that affected it are crucial to understanding the closure of the ocean. This paper presents a systematic investigation of the metamorphic P–T–t path of amphibolites from the Precambrian Huangyuan Group and Maxianshan Group in the Central Qilian block. An amphibole 40Ar/39Ar age of 456.7 ± 5.2 Ma from a garnet amphibolite and a 427.8 ± 3.8 Ma muscovite 40Ar/39Ar age from an orthogneiss in the Huangyuan Group, and amphibole and biotite 40Ar/39Ar ages of 408.7 ± 2.2 Ma and 349.9 ± 2.0 Ma from an amphibolite and a 361.4 ± 2.0 Ma biotite 40Ar/39Ar age from an orthogneiss in the Maxianshan Group record cooling stages after peak metamorphism. Phase equilibrium modeling of all amphibolite samples indicates clockwise P–T paths. A garnet amphibolite from the sillimanite zone in the Huangyuan Group recorded peak metamorphic conditions of 5.6–6.6 kbar and 730–770°C, reflecting granulite-facies metamorphism. Peak P–T conditions for a garnet amphibolite from the garnet zone are constrained to 580–600°C and 6–7 kbar. The amphibolite sample from the Maxianshan Group indicates peak P–T conditions of ~5.2 kbar and ~630°C. The Central Qilian block was affected by both southward subduction of the North Qilian Ocean and northward subduction of the South Qilian Ocean, which resulted in paired metamorphic belts along the northern margin of the Central Qilian block and accretion of the Hualong block to its southern margin. The subducted North Qilian oceanic slab detached and the remainder was exhumed at 453–445 Ma, accompanied by the extension and retrograde metamorphism of the overlying crust of Huangyuan Group at 457–428 Ma. Subsequent cooling of the Maxianshan Group indicates that the thermal regime relaxed during post-collisional extension at c. 409–350 Ma between the Hualong block and the Central Qilian block.
Physical Therapy and Mental Health: A Scoping Review
Authors: Heywood Sophie E , Connaughton Joanne , Kinsella Rita , Black Susie , Bicchi Nadia , Setchell Jenny
Published: August 2022

Objectives

Coexistence of mental and physical health conditions is prevalent. To achieve optimal physical therapy outcomes, neither should be treated in isolation. This review aimed to map intersections between physical therapy and mental health.

Methods

This was a scoping review searching MEDLINE, CINAHL, PsycInfo, Cochrane, and PEDro databases. Two independent researchers screened studies of physical therapy practice with adolescents/adults with mental health disorders or research using primary mental health outcomes in physical health conditions or clinicians’ perspective. Data were extracted on study type, participants, topics, publication year, and country.

Results

The search yielded 3633 studies with 135 included. Five studies included adolescents. More than one-half were published since 2015. Studies specific to participants with mental health diagnoses included schizophrenia (n = 12), depressive disorders (n = 8), eating disorders (n = 6), anxiety disorders (n = 4), bipolar disorders (n = 1), somatic disorders (n = 5), and trauma and stressor-related disorders (n = 8) or varied mental health diagnoses (n = 14). Forty-one studies had primary mental health outcomes or clinical practice approaches with a mental health emphasis with participants with physical health conditions (musculoskeletal [n = 13], neurological [n = 7], other [n = 21]). Systematic reviews or randomized controlled trials predominantly involved exercise therapy and/or physical activity. Descriptions of physical therapists as participants (n = 35) included 4 main topics: (1) mental health screening; (2) knowledge, attitudes, and experiences; (3) key practice components; and (4) research priorities.

Conclusion

Physical therapy intersects with people experiencing mental health disorders across a broad spectrum of diagnoses, covering a range of interventions with a small but growing evidence base.

Impact

Exercise and physical activity studies dominated the highest levels of evidence and future focus, although economic evaluations and consumer-driven or patient experience studies are needed. There is a contrast between the confidence and knowledge of specialized physical therapists working within mental health settings and those in general practice settings. Inspiring, integrated education is required to further improve health care outcomes following physical therapy for people with mental health disorders or symptoms.
There is high, and there is low: a qualitative examination of framings of inequality that Chinese people apply
Authors: Østerby-Jørgensen Andreas Michael
Published: August 2022

Economic inequality in China has increased significantly over the past four decades, and I examined the cultural resources that Chinese people have deployed to frame this new inequality. Based on 75 interviews with Chinese people, I identified three framings of inequality: The meritocratic framing views inequality as the result of differences in effort, ability or contribution; the developmental framing emphasizes that because everyone is doing materially better than four decades ago, it does not matter that economic inequality has increased; and what I call the difference-order framing, which emphasizes that individuals are born into different families with different levels of resources; therefore, they cannot be equal, which is not unfair. As such, even though China was a much more economically equal society just a few decades ago, available cultural resources enable Chinese people to frame inequality in ways that justify, rather than problematize, the phenomenon.
Effects of adding potassium bicarbonate to diets with high or low crystalline lysine to influence dietary cation–anion difference on finishing pig growth performance
Authors: Royall Rafe Q , Goodband Robert D , Tokach Mike D , DeRouchey Joel M , Woodworth Jason C , Gebhardt Jordan T
Published: August 2022

Dietary cation–anion difference (DCAD), calculated as Na+ + K+ – Cl− in mEq/kg of the diet, represents the influence that monovalent cations and anions from these minerals have on the acid–base status of the animal. However, the recommended range of DCAD for optimal grow-finish swine performance is variable, which may indicate an interaction between DCAD and other ingredients. The hypothesis for this study was that the addition of potassium bicarbonate (KHCO3) to increase diet DCAD when high levels of l-Lys HCl (>0.35% diet) are used may potentially improve growth performance. A total of 1,944 pigs (PIC L337 × 1050, initially 35.2 ± 0.85 kg) were used in a 120-d study. Pens of pigs were blocked by BW and randomly allotted to 1 of 4 dietary treatments in a randomized complete block design. Treatments were arranged in a 2 × 2 factorial with main effects of KHCO3 (0% or 0.4%), and l-Lys HCl level (low or high). l-Lys HCl was included between 0.13% and 0.21% in low diets, and between 0.36% and 0.43% in high diets. There were 27 pigs per pen and 18 replicates per treatment. Treatment diets were corn-soybean meal-based and formulated in four dietary phases (35–60 kg, 60–85 kg, 85–105 kg, and 105–130 kg). Dietary treatments were formulated such that in each phase the diet containing a low level of l-Lys HCl without KHCO3 and the diet containing a high level of l-Lys HCl with KHCO3 had similar calculated DCAD values (169–232 mEq/kg). Additionally, the diet with a low level of l-Lys HCl with KHCO3 was formulated to have the highest DCAD in each phase (220–281 mEq/kg), while the diet with a high level of l-Lys HCl without KHCO3 was formulated to have the lowest DCAD (118–182 mEq/kg). Overall, there was no evidence (P > 0.10) for a KHCO3 × l-Lys HCl interaction or main effect for final BW or any observed growth response or carcass characteristics. The results of this study suggest that supplementing KHCO3 to finishing pig diets with either high or low levels of l-Lys HCl and the corresponding changes in DCAD values did not impact growth performance or carcass characteristics.
Prefrontal cortical connectivity and coupling of infraslow oscillation in the resting human brain: a 2-channel broadband NIRS study
Authors: Shahdadian Sadra , Wang Xinlong , Kang Shu , Carter Caroline , Chaudhari Akhil , Liu Hanli
Published: August 2022

The resting-state infraslow oscillation (ISO) of the cerebral cortex reflects the neurophysiological state of the human brain. ISO results from distinct vasomotion with endogenic (E), neurogenic (N), and myogenic (M) frequency bands. Quantification of prefrontal ISO in cortical hemodynamics and metabolism in the resting human brain may facilitate the identification of objective features that are characteristic of certain brain disorders. The goal of this study was to explore and quantify the prefrontal ISO of the cortical concentration changes of oxygenated hemoglobin (Δ[HbO]) and redox-state cytochrome c oxidase (Δ[CCO]) as hemodynamic and metabolic activity metrics in all 3 E/N/M bands. Two-channel broadband near-infrared spectroscopy (2-bbNIRS) enabled measurements of the forehead of 26 healthy young participants in a resting state once a week for 5 weeks. After quantifying the ISO spectral amplitude (SA) and coherence at each E/N/M band, several key and statistically reliable metrics were obtained as features: (i) SA of Δ[HbO] at all E/N/M bands, (ii) SA of Δ[CCO] in the M band, (iii) bilateral connectivity of hemodynamics and metabolism across the E and N bands, and (iv) unilateral hemodynamic–metabolic coupling in each of the E and M bands. These features have promising potential to be developed as objective biomarkers for clinical applications in the future.
Brain Complexities and Anesthesia: Their Meaning and Measurement
Authors: Li Duan , Fabus Marco S. , Sleigh Jamie W.
Published: August 2022

A complex system is often associated with emergence of new phenomena from the interactions between the system’s components. General anesthesia reduces brain complexity and so inhibits the emergence of consciousness. An understanding of complexity is necessary for the interpretation of brain monitoring algorithms. Complexity indices capture the “difficulty” of understanding brain activity over time and/or space. Complexity–entropy plots reveal the types of complexity indices and their balance of randomness and structure. Lempel–Ziv complexity is a common index of temporal complexity for single-channel electroencephalogram containing both power spectral and nonlinear effects, revealed by phase-randomized surrogate data. Computing spatial complexities involves forming a connectivity matrix and calculating the complexity of connectivity patterns. Spatiotemporal complexity can be estimated in multiple ways including temporal or spatial concatenation, estimation of state switching, or integrated information. This article illustrates the concept and application of various complexities by providing working examples; a website with interactive demonstrations has also been created.
Addition of External Beam Radiation Therapy to Adjuvant Chemotherapy for Patients With Stage IIIC Uterine Endometrioid Carcinoma: Utilization and Outcomes
Authors: Nasioudis Dimitrios , Taunk Neil K. , Ko Emily M. , Haggerty Ashley F. , Cory Lori , Giuntoli Robert L. , Kim Sarah H. , Latif Nawar A.
Published: August 2022

Objectives:

Evaluate whether the addition of external beam radiation (EBRT) to adjuvant chemotherapy with or without vaginal brachytherapy is associated with better survival for patients with stage IIIC endometrioid endometrial carcinoma.

Materials and Methods:

Patients diagnosed between 2010 and 2015 with apparent early-stage endometrioid adenocarcinoma, without a history of another tumor, who underwent hysterectomy with lymphadenectomy and had positive lymph nodes were identified in the National Cancer Database. Those who received adjuvant chemotherapy (defined as receipt of treatment within 6 mo from surgery) and had at least 1 month of follow-up were selected for further analysis. Overall survival was compared between patients who did and did not receive EBRT within 6 months from surgery with the log-rank test. A Cox model was also constructed to control for confounders.

Results:

A total of 3116 patients were identified; 1458 (46.8%) received chemotherapy without and 1658 (53.2%) with EBRT. Pathologic characteristics (tumor grade, size, endocervical, and lymph-vascular invasion) were comparable between the two groups. Patients who received external beam radiation had better survival compared with those who did not, P=0.001; 5-year overall survival rates were 83.1% and 77.9%, respectively. After controlling for patient age, race, presence of comorbidities, insurance status, tumor size, grade and endocervical invasion, and the presence of lymph-vascular invasion, the addition of EBRT was associated with a survival benefit (HR: 0.75, 95% CI: 0.62, 0.91).

Conclusions:

For patients with endometrioid adenocarcinoma metastatic to the lymph nodes, addition of external beam radiation to adjuvant chemotherapy may be associated with a survival benefit.
Allogenic Umbilical Cord Tissue for Treatment of Knee Osteoarthritis
Authors: Gupta Ashim , Maffulli Nicola
Published: August 2022

Interest in use of perinatal allogenic tissues including clinical-grade minimally manipulated umbilical cord tissue-derived allograft formulations to treat knee osteoarthritis (OA) patients is increasing. Limited studies have characterized these formulations and evaluated their safety and efficacy in knee OA patients. We developed such formulation and reported the presence of growth factors, cytokines, hyaluronic acid, and exosomes. We reported that its administration is safe, and resulted in 50% pain reduction and improvement in knee injury and osteoarthritis outcome score (over 10%) and 36-item short form survey (25%). Another study reported no adverse events post injection of similar formulation and statistically significant (P<0.001) improvement in visual analog scale and Western Ontario and McMaster Universities Osteoarthritis Index scores and reduction in medication usage in patients (77.8%). We also summarized the clinical trials registered on ClinicalTrials.gov utilizing umbilical cord tissue for knee OA treatment. In conclusion, available studies are preliminary but pave the way to higher level appropriately powered investigations, and these formulations should be considered as nonoperative alternative to manage knee OA.
Osteoarthritis Risks and Sports: An Evidence-based Systematic Review
Authors: Migliorini Filippo , Maffulli Nicola , Pintore Andrea , Ernst Jeff , Eschweiler Joerg , Hildebrand Frank , Betsch Marcel
Published: August 2022

Purpose:

Regular sports activities are associated with multiple physical and psychological health benefits. However, sports also may lead to injuries and the development of osteoarthritis (OA). This systematic review investigated the association between sports activity, sports type, and the risk of developing OA.

Methods:

A systematic review was performed by assessing studies that have investigated the risk of OA development in sports. Data extracted included general information, study design, number of participants, related body mass index, sports type, and assessment of OA. The methodological quality of the studies was assessed using the Newcastle-Ottawa Scale.

Results:

A total of 63 studies were included in this systematic review. The overall Newcastle-Ottawa Scale score was 6.46±1.44 demonstrating a good methodological quality of the articles included in the present study. A total of 628,036 participants were included, with a mean follow-up of 8.0±8.4 years. The mean age of the included athletes was 45.6±15.8, with a mean body mass index of 24.9±2.3 kg/m2.

Conclusion:

Football and soccer players seem to be at higher risk for the development of OA, although the injury status of the joint should be considered when assessing the risk of OA. High equipment weight and increased injury risk also put military personnel at a higher risk of OA, although elite dancing leads to more hip labral tears. Femoroacetabular impingement was also often diagnosed in ice-hockey players and ballet dancers.
Physiopathology of nonalcoholic fatty liver disease: from diet to nutrigenomics
Authors: Meneghel Paola , Pinto Elisa , Russo Francesco Paolo
Published: August 2022

Purpose of review

Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide and is strongly associated with metabolic disorders, such as obesity, type 2 diabetes mellitus, and metabolic syndrome, to the extent that a new definition of metabolic associated fatty liver disease has been proposed.

Recent findings

Insulin resistance, worsened by a high-fat and high-carbohydrate diet, is the key to the physiopathology of hepatic steatosis. This is driven by several mechanisms that are mostly activated at a genetic level, such as de-novo lipogenesis and triglyceride synthesis. Therefore, many diet regimens have been studied, although significant controversies remain regarding their metabolic effects and long-term sustainability.

In this review, we summarized the role and effects of the main macronutrients on the development of NAFLD and discussed the molecular mechanisms involved. We also discussed the importance of genetic polymorphisms, epigenetic alterations, and dysbiosis to determine if lifestyle modification and a specific dietary regimen could be an essential part of NAFLD treatment.