bluuebunny/crossref_metadata_2025 huggingface dataset:
Intentional vomiting as a rare cause of hypercalcemia and consequent acute renal failure: a case report
Authors: Santini Mihovil , Sorić Ana , Mioč Pavao , Car Siniša , Đula Kristijan , Zeljkovic Ivan
Published: June 2024

Two most common causes of elevated serum calcium levels, which together account for nearly 90% of all cases, are primary hyperparathyroidism and malignancy. Thus, it is necessary to consider other disorders in the diagnostic evaluation of patients with hypercalcemia. We report the case of a 40-year-old female patient with an intellectual disability who was admitted to the Emergency Department with severe symptomatic hypercalcemia and acute renal failure, caused by recurrent intentional vomiting. The aim of this report is to help clinicians make an accurate diagnosis by considering recurrent vomiting habits as a potential cause of hypercalcemia and acute renal failure. Our case provides a comprehensive diagnostic work-up and multidisciplinary treatment strategies for patients with symptomatic hypercalcemia.
Association of obstructive sleep apnea syndrome with polycystic ovary syndrome through bidirectional Mendelian randomization
Authors: Liu Peijun , Zhang Qin , Ding Haitao , Zou Hua
Published: June 2024

Background

Observational studies have established a link between polycystic ovary syndrome (PCOS) and obstructive sleep apnea syndrome (OSAS), with obesity being a significant confounding factor that complicates the understanding of causality. This study seeks to clarify the causal relationship by utilizing bidirectional two-sample Mendelian randomization (MR) analysis.

Methods

A bidirectional MR strategy was implemented to investigate the potential causal relationship between PCOS and OSAS. Instrumental variables (IVs) for PCOS were sourced from a dataset comprising 3,609 cases and 229,788 controls. For OSAS, statistical data were obtained from a genome-wide association study (GWAS) involving 38,998 subjects, alongside a control group of 336,659 individuals. Our MR analysis utilized several methods, including inverse variance weighted (IVW), weighted mode, weighted median, simple mode, and MR-Egger, primarily focusing on the IVW technique. Sensitivity tests were conducted to ensure the robustness of our findings.

Results

Utilizing the IVW method, we identified a notable causal association from OSAS to PCOS, with an odds ratio (OR) of 1.463 and a 95% confidence interval (CI) of 1.086–1.971 (p = 0.012). In the opposite direction, PCOS also appeared to significantly affect OSAS development, indicated by an OR of 1.041 and a 95% CI of 1.012–1.072 (p = 0.006). The MR-Egger intercept test showed no evidence of directional pleiotropy, affirming the credibility of our causal findings (p > 0.05).

Conclusion

This study suggests a bidirectional causal relationship between PCOS and an increased risk of OSAS. These insights could guide future screening and prevention strategies for both conditions.
Changes in the gut microbiota of patients with sarcopenia based on 16S rRNA gene sequencing: a systematic review and meta-analysis
Authors: Song Qi , Zhu Youkang , Liu Xiao , Liu Hai , Zhao Xinyi , Xue Liyun , Yang Shaoying , Wang Yujia , Liu Xifang
Published: June 2024

Introduction

Sarcopenia, an age-related disease, has become a major public health concern, threatening muscle health and daily functioning in older adults around the world. Changes in the gut microbiota can affect skeletal muscle metabolism, but the exact association is unclear. The richness of gut microbiota refers to the number of different species in a sample, while diversity not only considers the number of species but also the evenness of their abundances. Alpha diversity is a comprehensive metric that measures both the number of different species (richness) and the evenness of their abundances, thereby providing a thorough understanding of the species composition and structure of a community.

Methods

This meta-analysis explored the differences in intestinal microbiota diversity and richness between populations with sarcopenia and non-sarcopenia based on 16 s rRNA gene sequencing and identified new targets for the prevention and treatment of sarcopenia. PubMed, Embase, Web of Science, and Google Scholar databases were searched for cross-sectional studies on the differences in gut microbiota between sarcopenia and non-sarcopenia published from 1995 to September 2023 scale and funnel plot analysis assessed the risk of bias, and performed a meta-analysis with State v.15. 1.

Results

A total of 17 randomized controlled studies were included, involving 4,307 participants aged 43 to 87 years. The alpha diversity of intestinal flora in the sarcopenia group was significantly reduced compared to the non-sarcopenia group: At the richness level, the proportion of Actinobacteria and Fusobacteria decreased, although there was no significant change in other phyla. At the genus level, the abundance of f-Ruminococcaceae; g-Faecalibacterium, g-Prevotella, Lachnoclostridium, and other genera decreased, whereas the abundance of g-Bacteroides, Parabacteroides, and Shigella increased.

Discussion

This study showed that the richness of the gut microbiota decreased with age in patients with sarcopenia. Furthermore, the relative abundance of different microbiota changed related to age, comorbidity, participation in protein metabolism, and other factors. This study provides new ideas for targeting the gut microbiota for the prevention and treatment of sarcopenia.

Systematic Review Registration

https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=475887, CRD475887.
State of the art of cervical cancer treatment in rare histologies
Authors: Arango-Bravo Eder Alexandro , Galicia-Carmona Tatiana , Cetina-Pérez Lucely , Flores-de la Torre Celia Beatriz , Enríquez-Aceves María Isabel , García-Pacheco José Antonio , Gómez-García Eva María
Published: June 2024

The objective of this review is to summarize the current scientific evidence to formulate clinical recommendations regarding the classification, diagnostic approach, and treatment of rare histological subtypes of cervical cancer; neuroendocrine carcinoma, gastric-type mucinous adenocarcinoma, and glassy cell adenocarcinoma. These histological subtypes are generally characterized by their low frequency, aggressive biological behavior, certain chemoradioresistance, and consequently, high recurrence rates with a deleterious impact on survival. Molecular studies have identified several associated mutations in neuroendocrine carcinoma (PIK3CA, MYC, TP53, PTEN, ARID1A, KRAS, BRCA2) and gastric-type adenocarcinoma (KRAS, ARID1A, PTEN) that may serve as molecular targets. While adenocarcinomas are typically treated and classified based on squamous histology across early, locally advanced, and advanced stages, the treatment strategies for neuroendocrine carcinomas in early stages or locally advanced cases differ, particularly in the sequencing of administering chemotherapy, chemoradiotherapy, or surgery. The chemotherapy regimen is based on etoposide plus cisplatin (EP). Unlike squamous cell carcinomas, immune checkpoint inhibitors are yet to establish a standard role in the treatment of recurrent neuroendocrine carcinomas due to the absence of clinical trials. Regarding glassy cell adenocarcinomas and gastric-type adenocarcinoma, the potential use of immunotherapy in advanced stages/disease requires further evaluation through international collaborations, given the limited number of cases.
Case report: Uncommon manifestations of Rosai-Dorfman disease in the liver mimicking HCC
Authors: Ren Huipeng , Zhang Hao , Wan Qinyun , Pang Yuhui , Tian Hongzhe , Ren Zhuanqin , Cai Yuan
Published: June 2024

Rosai-Dorfman-Destombes disease (RDD) is a rare non-Langerhans cell histiocytosis (LCH) disorder characterized by systemic extranodal lesions. Common cases include skin lesions, whereas liver lesions are rare. This study presents a case of a 66-year-old woman with a solitary extranodal liver lesion who underwent successful surgical treatment followed by glucocorticoid therapy. The patient did not experience any symptoms before surgery. The liver lesion was incidentally discovered during a routine ultrasound examination. Enhanced CT scan revealed the lesion with the characteristic of washout, similar to primary hepatic cancer (HCC). CT scans of the head, neck, chest, and abdominal pelvis revealed no lymph node or other organ lesions. After surgery, the liver lesion was diagnosed as RDD, and subsequent whole-body examinations did not reveal any skin lesions. The definitive diagnosis was solid liver RDD in adults. Although there were no typical cases of bilateral cervical lymph node lesions, ultrasound and CT examinations promptly detected liver lesions, leading to the correct diagnosis through surgical resection. The findings from this case indicate that RDD can occur in rare extrasegmental areas, and the imaging characteristics of liver lesions are not specific, indicating the importance of avoiding delayed diagnosis.
Treatment of AL amyloidosis in the era of novel immune and cellular therapies
Authors: Sarubbi Caitlin , Abowali Hesham , Varga Cindy , Landau Heather
Published: June 2024

Light chain (AL) amyloidosis is a plasma cell disorder distinguished from multiple myeloma (MM) by the degree of organ involvement due to tissue deposition of misfolded proteins. Treatments for AL amyloidosis have largely been borrowed from those developed for patients with MM. High-dose chemotherapy followed by autologous stem cell transplant (ASCT) has historically been associated with the best outcomes. The recent incorporation of daratumumab into up front therapy represents a significant advance and has changed the treatment paradigm, calling into question the role of ASCT. The development of very active novel immune and cellular therapies, specifically B cell maturation antigen (BCMA)-directed therapies, has similarly been transformative for patients with MM and is now being studied in patients with AL amyloidosis. These include chimeric antigen receptor (CAR) T cells, bispecific antibodies, and antibody drug conjugates. Although limited, preliminary data in patients with relapsed and refractory AL amyloidosis are showing promising results, and it is expected that the treatment landscape for AL amyloidosis will continue to evolve. Particular attention to safety, potential for organ recovery, and quality of life will be important when evaluating new treatments and/or treatment paradigms.
Structure-based screening of FDA-approved drugs identifies potential histone deacetylase 3 repurposed inhibitor: molecular docking and molecular dynamic simulation approaches
Authors: Shamsi Anas , Khan Mohd Shahnawaz , Yadav Dharmendra Kumar , Shahwan Moyad
Published: June 2024

Histone deacetylase 3 (HDAC3) is a member of the histone deacetylase family that has emerged as a crucial target in the quest for novel therapeutic interventions against various complex diseases, including cancer. The repositioning of FDA-approved drugs presents a promising avenue for the rapid discovery of potential HDAC3 inhibitors. In this study, we performed a structure-based virtual screening of FDA-approved drugs obtained from DrugBank. Candidate hits were selected based on their binding affinities and interactions with HDAC3. These promising hits were then subjected to a comprehensive assessment of their biological properties and drug profiles. Our investigation identified two FDA-approved drugs, Imatinib and Carpipramine, characterized by their exceptional affinity and specificity for the binding pocket of HDAC3. These molecules demonstrated a strong preference for HDAC3 binding site and formed interactions with functionally significant residues within the active site pocket. To gain deeper insights into the binding dynamics, structural stability, and interaction mechanisms, we performed molecular dynamics (MD) simulations spanning 300 nanoseconds (ns). The results of MD simulations indicated that Imatinib and Carpipramine stabilized the structure of HDAC3 and induced fewer conformational changes. Taken together, the findings from this study suggest that Imatinib and Carpipramine may offer significant therapeutic potential for treating complex diseases, especially cancer.
The proteomic landscape of sperm surface deciphers its maturational and functional aspects in buffalo
Authors: Batra Vipul , Dagar Komal , Diwakar Maharana Pratap , Kumaresan Arumugam , Kumar Rakesh , Datta Tirtha Kumar
Published: June 2024

Buffalo is a dominant dairy animal in many agriculture-based economies. However, the poor reproductive efficiency (low conception rate) of the buffalo bulls constrains the realization of its full production potential. This in turn leads to economic and welfare issues, especially for the marginal farmers in such economies. The mammalian sperm surface proteins have been implicated in the regulation of survival and function of the spermatozoa in the female reproductive tract (FRT). Nonetheless, the lack of specific studies on buffalo sperm surface makes it difficult for researchers to explore and investigate the role of these proteins in the regulation of mechanisms associated with sperm protection, survival, and function. This study aimed to generate a buffalo sperm surface-specific proteomic fingerprint (LC-MS/MS) and to predict the functional roles of the identified proteins. The three treatments used to remove sperm surface protein viz. Elevated salt, phosphoinositide phospholipase C (PI-PLC) and in vitro capacitation led to the identification of N = 1,695 proteins (≥1 high-quality peptide-spectrum matches (PSMs), p < 0.05, and FDR<0.01). Almost half of these proteins (N = 873) were found to be involved in crucial processes relevant in the context of male fertility, e.g., spermatogenesis, sperm maturation and protection in the FRT, and gamete interaction or fertilization, amongst others. The extensive sperm-surface proteomic repertoire discovered in this study is unparalleled vis-à-vis the depth of identification of reproduction-specific cell-surface proteins and can provide a potential framework for further studies on the functional aspects of buffalo spermatozoa.
Evolution of Whirly1 in the angiosperms: sequence, splicing, and expression in a clade of early transitional mycoheterotrophic orchids
Authors: Muti Rachel M. , Barrett Craig F. , Sinn Brandon T.
Published: June 2024

The plastid-targeted transcription factor Whirly1 (WHY1) has been implicated in chloroplast biogenesis, plastid genome stability, and fungal defense response, which together represent characteristics of interest for the study of autotrophic losses across the angiosperms. While gene loss in the plastid and nuclear genomes has been well studied in mycoheterotrophic plants, the evolution of the molecular mechanisms impacting genome stability is completely unknown. Here, we characterize the evolution of WHY1 in four early transitional mycoheterotrophic orchid species in the genus Corallorhiza by synthesizing the results of phylogenetic, transcriptomic, and comparative genomic analyses with WHY1 genomic sequences sampled from 21 orders of angiosperms. We found an increased number of non-canonical WHY1 isoforms assembled from all but the greenest Corallorhiza species, including intron retention in some isoforms. Within Corallorhiza, phylotranscriptomic analyses revealed the presence of tissue-specific differential expression of WHY1 in only the most photosynthetically capable species and a coincident increase in the number of non-canonical WHY1 isoforms assembled from fully mycoheterotrophic species. Gene- and codon-level tests of WHY1 selective regimes did not infer significant signal of either relaxed selection or episodic diversifying selection in Corallorhiza but did so for relaxed selection in the late-stage full mycoheterotrophic orchids Epipogium aphyllum and Gastrodia elata. Additionally, nucleotide substitutions that most likely impact the function of WHY1, such as nonsense mutations, were only observed in late-stage mycoheterotrophs. We propose that our findings suggest that splicing and expression changes may precede the selective shifts we inferred for late-stage mycoheterotrophic species, which therefore does not support a primary role for WHY1 in the transition to mycoheterotrophy in the Orchidaceae. Taken together, this study provides the most comprehensive view of WHY1 evolution across the angiosperms to date.
Artemisia smithii patches form fertile islands and lead to heterogeneity of soil bacteria and fungi within and around the patches in alpine meadows of the Qinghai-Tibetan Plateau
Authors: Yang Hang , Yu Xiaojun , Song Jianchao , Wu Jianshuang
Published: June 2024

Herbivore-avoided plant patches are one of the initial characteristics of natural grassland degradation. These vegetation patches can intensify the spatial heterogeneity of soil nutrients within these grasslands. However, the effects of non-edible plant patches patches on the spatial heterogeneity of microorganisms have not been sufficiently studied in alpine meadows of the Qinghai-Tibetan Plateau, especially patches formed by herbaceous plants. To answer this question, soil nutrients, plant assembly, and microbial communities were measured inside, around, and outside of Artemisia smithii patches. These were 0 m (within the patch), 0–1 m (one meter from the edge of the patch), 1–2 m (two meters from the edge of the patch), 2–3 m (three meters from the edge of the patch), and >30 m (non-patch grassland more than thirty meters from the edge of the patch). Our results showed that A. smithii patches accumulated more aboveground biomass (AGB) within the patches (0 m), and formed fertile islands with the soil around the patches. Additionally, A. smithii patches increased soil bacterial diversity within (0 m) and around (0–1 m) the patches by primarily enriching copiotrophic bacteria (Actinobacteria), while the diversity of fungal communities increased mainly in the 0–1 m area but not within the patches. Bacterial community diversity was driven by pH, urease, nitrate nitrogen (NO3−-N), and microbial biomass carbon (MBC). The contents of soil water (SWC), soil organic matter (SOM), urease, NO3−-N, and MBC were the main factors influencing the diversity of the fungal community. This study elucidates the vegetation, nutrients, and microbial heterogeneity and their interrelationships, which are observed in fertile islands of herbivore-avoided plant patches in alpine meadows, and provides further insights into the spatial pattern of nutrients in patchy degraded grasslands.
Statelessness of an ethnic minority: the case of Rohingya
Authors: Bhattacharjee Mowsume
Published: June 2024

This paper examines why and how Myanmar makes Rohingyas a stateless community in Southeast Asia, known as one of the most vulnerable human groups in the contemporary world. Based on the secondary evidence, the paper argues that Rohingyas are stateless because they are the victim of four discourses: former Bangladeshi people who illegally entered Myanmar; collaborators to British armies while Myanmar was fighting for its independence from British rule; attachment to Islamic terrorism; and foreign interests in the Rakhine state. The paper draws on a wide range of local and global literature to support its arguments. The paper uses extant sociological approaches to understand why a minority community becomes stateless and experiences genocide in their own country. The researcher developed an analytical framework to answer the research questions. This analytical framework draws on existing literature, recent strategies, theoretical understandings, contemporary data, and government responses to understand the process of Rohingya statelessness. This paper finds that Myanmar not only expelled Rohingyas from their homeland by imposing the blame on them but is also unwilling to return over a million Rohingyas from Bangladesh—a host country for them. The paper also finds that the international community is least concerned about the genocide and expulsion of the Rohingyas because of Myanmar’s communal agenda and foreign countries’ economic interests in the Rakhine state. The paper offers some recommendations to address this unique inhuman condition in its concluding part.
Alone but not isolated: social presence and cognitive load in learning with 360 virtual reality videos
Authors: Ki Suhyun , Park Sanghoon , Ryu Jeeheon , Kim Jongho , Kim Inki
Published: June 2024

Introduction

This study aimed to identify any differences in social presence and cognitive load among three types of 360 virtual reality (VR)-based videos lectures. We hypothesized that social presence would be higher when interactions among peers are visible in a 360 VR video lectures while the cognitive load would be also increased.

Methods

A total of 48 college students were randomly assigned to one of the three study groups to view an assigned 360 VR video lecture. The three groups were: (1) an instructor-only video viewing group, (2) a classroom lecture video viewing group, and (3) a classroom lecture and activity video viewing group. The video lectures were differently designed depending on the levels of peer visibility and the interactions between the instructor and peers. The participants watched one of the three types of assigned video lecture and subsequently completed two sets of questionnaires regarding social presence and cognitive load. A multivariate analysis of variance (MANOVA) was conducted with a planned contrast analysis for the type of video lectures.

Results

We found that, contrary to the hypotheses, students in the group 1 (instructor-only video) showed higher social presence scores than students in the groups 2 and 3. However, no significant differences were found in the cognitive load scores.

Discussion

The results show that 360 VR video lectures with an instructor-only are more effective at enhancing users’ social presence than 360 VR video lectures with both the instructor and class-peers. We suggest creating 360 VR video lectures with the presence of the course instructor to offer learners the sense of actually participating in a lecture.
Busting MisconSEXions: evaluation of a social media knowledge translation initiative addressing myths about sex
Authors: O’Kane Kiarah M. K. , Goldberg Simone Y. , Bouchard Katrina N. , Dawson Samantha J.
Published: June 2024

There is a critical gap in sex education such that many people lack access to evidence-based and accessible information about sexuality, putting them at risk for endorsing myths about sex and in turn having poorer sexual wellbeing. To address this gap, we developed a novel social media knowledge translation initiative—MisconSEXions—to debunk common myths about sexuality. The goal of this study was twofold. First, to examine whether exposure to MisconSEXions is effective for reducing sexuality myth endorsement. Second, to evaluate the acceptability (participants’ satisfaction with the content), appropriateness (the perceived fit of the content with participants), adoption (participants’ intention to engage with the initiative), and penetration (participants’ perception of the content’s impact on their lives) of MisconSEXions among study participants. We also examined possible group differences in our observed effects by assigned sex, gender modality, and sexual orientation. A large and diverse sample (N = 2,356) of adults completed an online survey and reported on their demographics, sexuality myth endorsement before and after exposure to MisconSEXions content, and the acceptability, appropriateness, adoption, and penetration of the MisconSEXions content. We found that participants’ sexuality myth endorsement was significantly lower following exposure to MisconSEXions content, and this effect held across assigned sex, gender modality, and sexual orientation groups. Regardless of participants’ assigned sex, gender modality, or sexual orientation, MisconSEXions content was reported to be both acceptable and appropriate to people’s lives. Participants reported relatively low levels of adoption, such that they reported reluctance to engage with the content on social media. Additionally, participants reported mixed feelings regarding the impact of the content on their lives (i.e., penetration). Overall, the findings have implications for how sexuality social media knowledge translation initiatives can fill important gaps in providing inclusive and accessible sex education.
Social accessibility in queering code/space: Blued-based visibility and social practices of local gay people in mainland China
Authors: Xu Tongwen , Zhang Yansong
Published: June 2024

As a locative media, Blued articulates physical and digital space in the form of localization, giving a mediated visibility to its users who are not visible in physical space, thus making the city a queering code/space. This can transform social accessibility and the ways that gays come together and interact in local spaces. Taking mainland China, dominated by heteronomativity, as a field, this paper focuses on the visibility negotiation and social accessibility practices in Blued-based queering code/space. Using the digital anthropology method, this study found that Blued-based visibility is essential for non-closeted gay men to gain a sense of local belonging and community inclusion. Offline accessibility is a crucial demand for Blued users, but until then they have negotiated visibility through selective disclosure of social cues. At the same time, Blued users face visibility asymmetries and risks in the pursuit of accessibility. This study then argues that in the Blued-based queering code/space, the gay men constantly reconcile accessibility with others by managing visibility in a heteronormative urban space. In addition, this paper highlights the value of the hybrid of new media and physical space for the public interaction of marginalized groups in the city.
Higher homocysteine and fibrinogen are associated with early-onset post-stroke depression in patients with acute ischemic stroke
Authors: Deng Mingzhu , Zhou Nina , Song Kangping , Wang Zhen , Zhao Wei , Guo Jiayu , Chen Sufen , Tong Yangping , Xu Wei , Li Fangyi
Published: June 2024

Background

Post-stroke depression (PSD) is a well-established psychiatric complication following stroke. Nevertheless, the relationship between early-onset PSD and homocysteine (Hcy) or fibrinogen remains uncertain.

Methods

Acute ischemic stroke (AIS) patients who met the established criteria were enrolled in this study. Early-onset PSD was diagnosed two weeks after the stroke. The severity of depressive symptoms was assessed by the Hamilton Depression Scale-17 items (HAMD-17), with patients scored ≥7 assigned to the early-onset PSD group. Spearman rank correlation analysis was employed to evaluate the associations between Hcy, fibrinogen, and HAMD scores across all patients. Logistic regression analysis was conducted to investigate the relationship between Hcy, fibrinogen, and early-onset PSD. Receiver operating characteristic curve (ROC) analysis was ASSDalso performed to detect the predictive ability of Hcy and fibrinogen for early-onset PSD.

Results

Among the 380 recruited patients, a total of 106 (27.89%) patients were diagnosed with early-onset PSD. The univariate analysis suggested that patients in the PSD group had a higher admission National Institutes of Health Stroke Scale (NIHSS) score, modified Rankin Scale score (mRS), Hcy, and fibrinogen levels than patients in the non-PSD group (P<0.05). The logistic regression model indicated that Hcy (odds ratio [OR], 1.344; 95% confidence interval [CI] 1.209–1.494, P<0.001) and fibrinogen (OR, 1.57 6; 95% CI 1.302–1.985, P<0.001) were independently related to early-onset PSD. Area under curve (AUC) of Hcy, fibrinogen, and Hcy combined fibrinogen to predict early-onset PSD was 0.754, 0.698, and 0.803, respectively.

Conclusion

This study indicates that Hcy and fibrinogen may be independent risk factors for early-onset PSD and can be used as predictive indicators for early-onset PSD.
Improvements in the quality of the parent-child relationship following treatment with an integrated family approach
Authors: Stolper Hanna , Imandt Lieke , van Doesum Karin , Steketee Majone
Published: June 2024

Objective

This study investigated changes in the emotional availability of the parent and the child in the dyadic relationship, parental reflective functioning, and parental perception of the relationship with their child following treatment with an integrated family approach in adult and child mental health care services. The aim of the study was to investigate if an integrated family approach in treatment contributes to good practice in mental health care.

Background

Children of parents with a mental disorder are at increased risk for developing mental health problems themselves during lifetime. Infants are extremely vulnerable for environmental influences. Parents with mental disorders are at risk for mis-attuned behavior and non-optimal emotional availability. This increases the risk of adverse cascading effects on the parent-child relationship and child development. A secure parent-child relationship is an important protective factor against the intergenerational transmission of mental disorders. Although treatment of the parental mental disorder is important, it does not automatically change undesirable patterns in the parent-child relationship. Therefore, an integrated family approach to mental health treatment is recommended.

Methods

This study involved a mixed methods design using questionnaires, an observation instrument and semi-structured interviews. The variables examined were the quality of the parent-child interaction, the parental perspective on their relationship with the child, their problems with child upbringing, and on their parental reflective functioning. The clinical sample consisted of 50 patients with a variety of mental disorders and their young children.

Results

After finishing the integrated treatment the quality of the parent-child interaction had improved significantly. Likewise, we found a significant improvement in parental perception regarding the relationship with the child and the parental role. The majority of the parents interviewed showed that they were better able to mentalize about themselves, their child and their relationship with the child, but the data from the questionnaire showed mixed results regarding parents’ reflective functioning.

Conclusion

Treatment with an integrated family approach to mental health care in which the parental role of the patient, the young child, and the parent-child relationship are integrated in treatment, can be a valuable addition to the current practice of mental health care in which patients are commonly perceived as individuals.
Multi-modal deep learning from imaging genomic data for schizophrenia classification
Authors: Kanyal Ayush , Mazumder Badhan , Calhoun Vince D. , Preda Adrian , Turner Jessica , Ford Judith , Ye Dong Hye
Published: June 2024

Background

Schizophrenia (SZ) is a psychiatric condition that adversely affects an individual’s cognitive, emotional, and behavioral aspects. The etiology of SZ, although extensively studied, remains unclear, as multiple factors come together to contribute toward its development. There is a consistent body of evidence documenting the presence of structural and functional deviations in the brains of individuals with SZ. Moreover, the hereditary aspect of SZ is supported by the significant involvement of genomics markers. Therefore, the need to investigate SZ from a multi-modal perspective and develop approaches for improved detection arises.

Methods

Our proposed method employed a deep learning framework combining features from structural magnetic resonance imaging (sMRI), functional magnetic resonance imaging (fMRI), and genetic markers such as single nucleotide polymorphism (SNP). For sMRI, we used a pre-trained DenseNet to extract the morphological features. To identify the most relevant functional connections in fMRI and SNPs linked to SZ, we applied a 1-dimensional convolutional neural network (CNN) followed by layerwise relevance propagation (LRP). Finally, we concatenated these obtained features across modalities and fed them to the extreme gradient boosting (XGBoost) tree-based classifier to classify SZ from healthy control (HC).

Results

Experimental evaluation on clinical dataset demonstrated that, compared to the outcomes obtained from each modality individually, our proposed multi-modal approach performed classification of SZ individuals from HC with an improved accuracy of 79.01%.

Conclusion

We proposed a deep learning based framework that selects multi-modal (sMRI, fMRI and genetic) features efficiently and fuse them to obtain improved classification scores. Additionally, by using Explainable AI (XAI), we were able to pinpoint and validate significant functional network connections and SNPs that contributed the most toward SZ classification, providing necessary interpretation behind our findings.
Identifying factors influencing local governments’ adoption of comprehensive smoke-free policies: an event history analysis based on panel data from 36 key cities in China (2013–2021)
Authors: Feng Wenting , Qin Binbin , Jin Xuezheng , Li Shengyu
Published: June 2024

Introduction

The issue of tobacco control remains a significant concern for public health worldwide. In recent years, remarkable progress has been made toward adopting smoke-free measures in indoor public places. Although China has yet to introduce a national regulation, specifically for smoke-free public places, more than a dozen cities have successively approved and implemented comprehensive smoke-free regulations. Different cities in China have diverse attitudes and behaviors toward smoke-free policies; however, the reasons for these policy differences and the influencing factors have not received sufficient attention and research.

Methods

On the basis of the multiple streams framework, this study selects 36 key Chinese cities as research samples and uses a directed dyad-year event history analysis method to analyze the factors influencing the implementation of comprehensive smoke-free policies in cities.

Results

Results show that the adoption of such policies is positively influenced by scientific evidence, focal events, media coverage, institutional foundations, economic comparisons, and the influence of health departments and of tobacco control groups. By contrast, policy adoption is negatively affected by the differences in administrative levels, central policy signals, and the influence of the tobacco industry.

Discussion

This study contributes to understanding the internal logic behind local governments’ adoption of comprehensive smoke-free policies, offering insights for further advocacy at the city and national levels in China and providing experiences that can promote the global tobacco control movement.
Strengthening collaboration within Dutch municipalities for a healthier living environment: experiences and possible improvements according to civil servants
Authors: Mourits Kristine , Spitters Hilde , van der Velden Koos , Bekker Marleen , Molleman Gerard
Published: June 2024

Background

Health is partly determined by the physical environment in which people live. It is therefore crucial to consider health when designing the physical living space. This requires collaboration between the social and physical domains within municipalities. Collaboration is not self-evident, however, and it is difficult to achieve due to barriers relating to culture, language and work processes. Additionally, improvements in collaboration are desperately needed to address complex health issues, and working according to the new Environment and Planning Act in the Netherlands requires more collaboration. One relevant question concerns how civil servants describe the current collaboration between the social and physical domain and the concrete improvements they propose to improve such collaboration to build a healthier living environment.

Methods

In this qualitative study, the Collaborative Governance framework was used to present data from semi-structured interviews with 21 civil servants in five Dutch municipalities. Respondents were asked to reflect on their current experiences with collaboration and suggest concrete opportunities for improving collaboration.

Results

The results indicate that enhancing collaboration between the social and physical domains can be achieved by proceeding from the inhabitants’ perspective, as well as by encouraging aldermen and managerial personnel to take a more active and committed role in collaboration. This involves formulating and communicating a joint vision, in addition to guiding and facilitating collaboration through integrated assignments, forming multidisciplinary teams and appointing boundary-spanners. Civil servants see a clear role for themselves in the collaborative process. They recognize their own contributions to and obligations in enhancing collaboration by actively seeking contact, absorbing each other’s perspectives and pursuing common ground, starting today.

Conclusion

There are many concrete opportunities to improve collaboration between the social and physical domains. This could be initiated immediately if civil servants, managers and aldermen approach collaboration as an essential part of their jobs and acknowledge the interdependency that exits.
A scoping review of olfactory interventions for fatigue relief: addressing occupational health hazards
Authors: Jiang Xinyue , Muthusamy Kanesan , Fang Xueliang
Published: June 2024

Background

Fatigue poses risks to occupational health and safety, affecting individuals' work efficiency, physical health, and social security, as well as human wellbeing and quality of life. Olfactory interventions, due to their low interference, are considered promising strategies for mitigating fatigue and reducing occupational health hazards.

Objective

The objective of this review is to bridge the current gaps in the literature by conducting a scoping review of olfactory interventions on human alertness. It aims to explore their application in various occupational settings and to provide comprehensive and practical guidance for the practical application of olfactory interventions in mitigating fatigue and reducing occupational risks.

Methods

The literature research was conducted in English using electronic databases such as Web of Science. Keywords related to scent and fatigue and the review followed PRISMA Extension for Scoping Reviews and PICO framework.

Results

28 studies were included in this work. Participant characteristics, fatigue measurement methods, and scent intervention methods, such as types of scents, intervention strategies, and scent presentation systems, are thoroughly investigated and discussed. Additionally, the study places a specific emphasis on the applications and research within the field of scent interventions for fatigue driving. Olfactory interventions have been applied to populations in various occupational fields, demonstrating beneficial effects on both physiological and psychological fatigue.

Conclusions

Olfactory intervention is effective and promising for enhancing alertness and improving the occupational environment. To provide detailed and practical guidance for the actual application of olfactory intervention in fatigue relief and reducing occupational health and safety hazards, further research into the potential mechanisms, applications, and efficacy assessment systems of fatigue-related olfactory interventions is necessary.
Molecular characterization and phylogenetic analyses of MetAP2 gene and protein of Nosema bombycis isolated from Guangdong, China
Authors: Qazi Izhar Hyder , Yuan Ting , Yang Sijia , Angel Christiana , Liu Jiping
Published: June 2024

Background

Pebrine, caused by microsporidium Nosema bombycis, is a devastating disease that causes serious economic damages to the sericulture industry. Studies on development of therapeutic and diagnostic options for managing pebrine in silkworms are very limited. Methionine aminopeptidase type 2 (MetAP2) of microsporidia is an essential gene for their survival and has been exploited as the cellular target of drugs such as fumagillin and its analogues in several microsporidia spp., including Nosema of honeybees.

Methods

In the present study, using molecular and bioinformatics tools, we performed in-depth characterization and phylogenetic analyses of MetAP2 of Nosema bombycis isolated from Guangdong province of China.

Results

The full length of MetAP2 gene sequence of Nosema bombycis (Guangdong isolate) was found to be 1278 base pairs (bp), including an open reading frame of 1,077 bp, encoding a total of 358 amino acids. The bioinformatics analyses predicted the presence of typical alpha-helix structural elements, and absence of transmembrane domains and signal peptides. Additionally, other characteristics of a stable protein were also predicted. The homology-based 3D models of MetAP2 of Nosema bombycis (Guangdong isolate) with high accuracy and reliability were developed. The MetAP2 protein was expressed and purified. The observed molecular weight of MetAP2 protein was found to be ~43–45 kDa. The phylogenetic analyses showed that MetAP2 gene and amino acids sequences of Nosema bombycis (Guangdong isolate) shared a close evolutionary relationship with Nosema spp. of wild silkworms, but it was divergent from microsporidian spp. of other insects, Aspergillus spp., Saccharomyces cerevisiae, and higher animals including humans. These analyses indicated that the conservation and evolutionary relationships of MetAP2 are closely linked to the species relationships.

Conclusion

This study provides solid foundational information that could be helpful in optimization and development of diagnostic and treatment options for managing the threat of Nosema bombycis infection in sericulture industry of China.
Cooperative Integrated Guidance and Control for Active Target Protection in Three-Player Conflict
Authors: Gong Xiaopeng , Chen Wanchun , Chen Zhongyuan
Published: June 2024

This paper addresses the active target protection problem in a three-player (Target–Attacker–Defender, TAD) conflict by proposing a cooperative integrated guidance and control (IGC) strategy. Unlike previous studies that have designed guidance and control loops separately, this work establishes an IGC model by linearizing both the translational motion and the rotational motion of the vehicles, thereby generating actuator commands directly. This model integrates the kinematics and short-period dynamics, providing a more comprehensive and accurate representation of the vehicles’ characteristics. Based on the linearization and order reduction, differential game theory and the sweep method are employed to derive and analytically solve the Riccati differential equation, yielding an optimal control strategy with an explicit expression. The theoretical rigor of the proposed approach is ensured through a proof of optimality sufficiency. Furthermore, factors influencing the computational accuracy of the Riccati equation solution, including the singular values of the control matrix and condition numbers of the solution matrix, are analyzed. Taking into account the dynamic response and limitations of the actuators, numerical simulations demonstrate the effectiveness and superiority of the proposed IGC strategy in intercepting the attacker and protecting the target compared to traditional separated guidance and control designs.
Interplay of Influencing Factors Shaping Entrepreneurial Intention: Evidence from Bangladesh
Authors: Talukder Saurav Chandra , Lakner Zoltan , Temesi Ágoston
Published: June 2024

This study examines the relationships between risk-taking propensity (RTP), entrepreneurship education support (EES), need for achievement (NFA), and entrepreneurial intentions (EI) of Bangladeshi university students, as well as the mediating roles of attitude toward entrepreneurship (ATE), subjective norms (SN), and perceived behavioral control (PBC). Using partial least squares structural equation modeling (PLS-SEM), the study was conducted with a sample of 381 respondents. Results show that attitudes play a mediating role in the relationship between RTP and EI, and RTP has a direct positive effect on attitudes toward entrepreneurship and EI. Although EES does not have a direct effect on EI, it does have a positive effect on all other components of the theory of planned behavior (TPB), which in turn influences EI. Perceived behavioral control and attitudes toward entrepreneurship serve as full mediators of the EES-EI connection. Subjective norms, on the other hand, have no relationship with EI and do not serve as a mediator between the EES and EI relationship. However, NFA and EI do not have a direct relationship; NFA influences EI indirectly via perceived behavioral control, which in turn influences EI directly. This research contributes to the existing literature by offering significant theoretical and practical insights into the factors that influence entrepreneurial intentions among university students in developing economies.
Precise Modeling and Analysis of Aviation Power System Reliability via the Aviation Power System Reliability Probability Network Model
Authors: Wang Yao , Wang Fengtao , Li Shujuan , Zhang Yongjie
Published: June 2024

This study addresses the challenges of accurately analyzing the reliability of aviation power systems (APS) using traditional models by introducing the Aviation Power System Reliability Probability Network Model (APS-RPNM). The model directly transforms the system architecture into an equivalent probability network, aiming to develop a precise reliability model that captures system functions and fault logic. By classifying APS components into five distinct structural patterns and mapping them to corresponding nodes in the APS-RPNM, the model is successfully constructed. Specifically, None-Input-to-Multiple-Output components are transformed into two-state nodes, while Multiple-Input-to-None-Output, Single-Input-to-Multiple-Output, and Multiple-Input-to-Single-Output components are mapped to three-state nodes. For Multiple-Input-to-Multiple-Output components, a novel approach employing multiple two-state sub-nodes is adopted to capture their complex functional logic. A case study comparing the performance of the APS-RPNM with the traditional minimal path set method in reliability analysis was conducted. The results demonstrate that the APS-RPNM not only simplifies the model construction process and eliminates errors stemming from subjective engineering judgments but also enables the efficient computation of power supply reliability for all load points in a single inference by integrating all of the components. This significantly improves computational efficiency and system dependency analysis capabilities, highlighting the APS-RPNM’s tremendous potential in optimizing the reliability design of APS.