bluuebunny/crossref_metadata_2025 huggingface dataset:
Validation of metrological traceability of the new generation of Abbott Alinity alkaline phosphatase assay
Authors: Bianchi Giorgia , Frusciante Erika , Colombo Giulia , Infusino Ilenia , Aloisio Elena , Panteghini Mauro
Published: August 2023

Objectives

Recently, Abbott Diagnostics marketed a new generation of Alinity enzyme assays, introducing a multiparametric calibrator [Consolidated Chemistry Calibrator (ConCC)] in place of or in addition to factor-based calibrations. For alkaline phosphatase (ALP), both calibration options are offered, i.e., with ConCC (ALP2) and with an experimental calibration factor (ALP2F). Both options are declared traceable to the 2011 IFCC reference measurement procedure (RMP). Before to replace the old generation (ALP1) with the new one, we decided to validate the trueness of ALP2/ALP2F.

Methods

Three approaches were employed: (a) preliminary comparison on 48 native frozen serum samples with ALP1, of which traceability to RMP was previously successfully verified; (b) examination of three banked serum pools (BSP) with values assigned by RMP; (c) direct comparison with RMP on a set of 24 fresh serum samples. Bias estimation and regression studies were performed, and the standard measurement uncertainty associated with ALP measurements on clinical samples (uresult) was estimated and compared with established analytical performance specifications (APS). ConCC commutability was also assessed.

Results

A positive proportional bias was found with both ALP2 and ALP2F when compared to ALP1 and RMP. This positive bias was confirmed on BSP: in average, +13.1 % for ALP2 and +10.0 % for ALP2F, respectively. uresult were 13.28 % for ALP2 and 10.04 % for ALP2F, both not fulfilling the minimum APS of 4.0 %. Furthermore, ConCC was not commutable with clinical samples.

Conclusions

Our results unearth problems in the correct implementation of traceability of Alinity ALP2/ALP2F, with the risk for the new assay to be unfit for clinical purposes.
Lexical borrowing in Korean: a diachronic approach based on a corpus analysis
Authors: Oh Yoonjung , Son Hyunjung
Published: August 2023

Loanwords are lexical terms borrowed from foreign languages by transliterating the original sound of the borrowed words with the recipient language’s consonants and vowels. This paper focuses on lexical borrowing in the Korean language from a diachronic perspective. Based on approximately 9,500 Korean loanwords extracted from a corpus of women’s magazine articles of residential sections (the Korean Contemporary Residential Culture Corpus), we investigated the alteration of loanword usage from 1970 to 2015. Having introduced our definition of Korean loanwords in phonological and morphological terms, we performed statistical analysis particularly with type/token frequency and cultural/core loanwords, along with semantic analysis with Period Representative Loanword (PRL). We argue that, in addition to its gradual and rapid increase over time, Korean loanword usage underwent a remarkable evolution in the 1990s.
Strichartz inequality for orthonormal functions associated with special Hermite operator
Authors: Ghosh Sunit , Mondal Shyam Swarup , Swain Jitendriya
Published: August 2023

In this article, we derive the restriction theorem for the special Hermite transform and obtain the Strichartz estimate for the system of orthonormal functions associated with the special Hermite operator. Further, we discuss the optimal behavior of the constant as a limit of a large number of functions.
High isolation frequency-reconfigurable UWB-MIMO antenna with on-demand WiMAX band elimination
Authors: Saleem Summaiyya , Bhatnagar Deepak , Kumari Sarita , Siddiqui Mohd Gulman , Yadav Dinesh
Published: August 2023

In this article, a planar dual-element frequency reconfigurable multiple-input multiple-output (MIMO) antenna for ultra-wideband (UWB) applications is studied. The frequency band can be switched between UWB operation and single band rejected UWB performance using a pair of PIN diodes in the MIMO configuration. The presented antenna is comprised of two similar slotted circular radiators, having tapered microstrip feedlines and separate partial ground planes. An RT/Duroid 5880 substrate with size 54 × 54 mm2 is used for the design purpose. Rotational symmetry between the radiators and diagonally oriented t-shaped decoupling structure behind the substrate have been utilized for high isolation purpose. The designed MIMO antenna exhibits UWB performance in mode 1. In other mode, the antenna operates in the frequency range 2.46–10.44 GHz with Worldwide Interoperability for Microwave Access (WiMAX) band rejection. Thus, the MIMO antenna exhibits on-demand single band rejection behavior depending on the switching conditions of the diodes. The measured isolation is greater than −20 dB in both the modes. The presented MIMO configuration possesses compact and planar geometry with high gain, good isolation, ultrawideband performance with reconfigurable band elimination, high efficiency and efficient diversity performance parameters. The suggested antenna is a good choice to be utilized for portable UWB MIMO applications.
Monotone operators and a class of nonlinear elliptic equations on the Sierpiński gasket
Authors: Verma Amar Pal , Kar Rasmita
Published: August 2023

We study the existence of solutions for the nonlinear elliptic problem

-

Δ
⁢
v

-

λ
⁢

g
1

⁢
v

+

h
1

⁢

(
v
)

=

f
1

\displaystyle-\Delta v-\lambda g_{1}v+h_{1}(v)=f_{1}

in 
⁢
V

∖

V
0

,

\displaystyle\phantom{}\text{in }V\setminus V_{0},

v
=
0

\displaystyle v=0

on 
⁢

V
0

,

\displaystyle\phantom{}\text{on }V_{0},

where V is the Sierpiński gasket in

ℝ

N
-
1

{\mathbb{R}^{N-1}}

(

N
≥
2

{N\geq 2}

),

V
0

{V_{0}}

is its boundary (consisting of its N corners) and

λ
∈
ℝ

{\lambda\in\mathbb{R}}

. Here

f
1

,

g
1

:

V
→
ℝ

{f_{1},g_{1}:V\to\mathbb{R}}

,

h
1

:

ℝ
→
ℝ

{h_{1}:\mathbb{R}\to\mathbb{R}}

are the maps satisfying suitable hypotheses.
The Hydrogen Challenge: Requirements for Future Materials
Authors: Fechte-Heinen R. , Fuhrländer D. , Mehner A. , Decho H. , Castens M. , Burkart K. , Tinscher R. , Stührmann T.
Published: August 2023

The use of hydrogen as a climate-friendly energy source is gaining strongly in importance, as it represents the only solution for short- to medium-term decarbonization for some industrial sectors, such as the steel and basic materials industries. Increasing innovation density and scaling of electrolysis is creating a broader range of uses and applications. So-called green hydrogen can be used as a raw material (basic industry), process gas (direct steel reduction), burner gas (heat treatment) or energy carrier (e.g. transport, energy storage).

Depending on the application, hydrogen acts in a cryogenic liquid or gaseous state on the materials with which it comes into contact. This gives rise to various technical requirements that need to be controlled. For the application of hydrogen in large-scale and mass production, appropriate materials and processes will have to be developed that can be used economically and scalably.

Considerable R&D activities will be required in the future, from the processing of the starting materials, their property adjustment by heat treatment and coating, to manufacturing processes and testing. This article highlights the current status for selected areas and discusses future material requirements and development potential.
On the use of L-functionals in regression models
Authors: Hössjer Ola , Karlsson Måns
Published: August 2023

In this article, we survey and unify a large class or

L

L

-functionals of the conditional distribution of the response variable in regression models. This includes robust measures of location, scale, skewness, and heavytailedness of the response, conditionally on covariates. We generalize the concepts of

L

L

-moments (G. Sillito, Derivation of approximants to the inverse distribution function of a continuous univariate population from the order statistics of a sample, Biometrika 56 (1969), no. 3, 641–650.),

L

L

-skewness, and

L

L

-kurtosis (J. R. M. Hosking, L-moments: analysis and estimation of distributions using linear combinations or order statistics, J. R. Stat. Soc. Ser. B Stat. Methodol. 52 (1990), no. 1, 105–124.) and introduce order numbers for a large class of

L

L

-functionals through orthogonal series expansions of quantile functions. In particular, we motivate why location, scale, skewness, and heavytailedness have order numbers 1, 2, (3,2), and (4,2), respectively, and describe how a family of

L

L

-functionals, with different order numbers, is constructed from Legendre, Hermite, Laguerre, or other types of polynomials. Our framework is applied to models where the relationship between quantiles of the response and the covariates follows a transformed linear model, with a link function that determines the appropriate class of

L

L

-functionals. In this setting, the distribution of the response is treated parametrically or nonparametrically, and the response variable is either censored/truncated or not. We also provide a framework for asymptotic theory of estimates of

L

L

-functionals and illustrate our approach by analyzing the arrival time distribution of migrating birds. In this context, a novel version of the coefficient of determination is introduced, which makes use of the abovementioned orthogonal series expansion.
The function of Foxp1 represses β-adrenergic receptor transcription in the occurrence and development of bladder cancer through STAT3 activity
Authors: Ding Zhenshan , Jiao Binbin , Chen Xuelong , Chen Xing , Jiao Yangtian , Wang Jianfeng , Zhou Xiaofeng
Published: August 2023

Bladder cancer is a common malignant tumor. FOXP1 has been found to be abnormally expressed in tumors such as renal cell carcinoma and endometrial cancer. Here, this investigated the biological roles of Foxp1 in the occurrence and development of bladder cancer. Patients with bladder cancer were obtained from China-Japan Friendship Hospital. Bladder cancer cell lines (5637, UMUC3, J82, and T24 cell) were used in this experiment. Foxp1 mRNA and protein expression levels in patients with bladder cancer were increased, compared with paracancerous tissue (normal). OS and DFS of Foxp1 low expression in patients with bladder cancer were higher than those of Foxp1 high expression. Foxp1 promoted bladder cancer cell growth in vitro model. Foxp1 increased the Warburg effect of bladder cancer. Foxp1 suppressed β-adrenoceptor (β-AR) expression in vitro model. ChIP-seq showed that Foxp1 binding site (E1, TTATTTAT) was detected at −2,251 bp upstream of the β-AR promoter. β-AR Reduced the effects of Foxp1 on cell growth in vitro model. β-AR reduced the effects of Foxp1 on the Warburg effect in vitro model by STAT3 activity. Taken together, our findings reveal that Foxp1 promoted the occurrence and development of bladder cancer through the Warburg effect by the activation of STAT3 activity and repressing β-AR transcription, and which might serve as an important clue for its targeting and treatment of bladder cancer.
Effect of RUNX1/FOXP3 axis on apoptosis of T and B lymphocytes and immunosuppression in sepsis
Authors: Chao Yangfa , Huang Wenting , Xu Zhiheng , Li Ping , Gu Shaodong
Published: August 2023

Lymphocyte apoptosis is a latent factor for immunosuppression in sepsis. Forkhead box protein P3 (FOXP3) can interact with RUNX family transcription factor 1 (RUNX1) in regulatory T cells. Our research was to probe whether RUNX1/FOXP3 axis affects immunosuppression in the process of sepsis by modulating T and B lymphocyte apoptosis. We constructed sepsis model in mice and mouse CD4+ T and CD19+ B lymphocytes. RUNX1 and FOXP3 expressions and apoptosis in cells were assessed by western blot, quantitative real-time PCR, and flow cytometer. Inflammation of serum and pathological damage was assessed by ELISA and H&E staining. Relationship between RUNX1 and FOXP3 was assessed by co-immunoprecipitation. The findings showed that RUNX1 ameliorated the survival rate, pathological damage, and decreased inflammation-related factors, and inhibited apoptosis of CD4+ T and CD19+ B cells in cecal ligation and puncture mice. Furthermore, RUNX1 up-regulated the viability and down-regulated apoptotic rate with the changed expressions of apoptosis-related molecules in lipopolysaccharide (LPS)-mediated CD4+ T and CD19+ B cells. Additionally, FOXP3 interacted with RUNX1, and its silencing decreased RUNX1 expression and reversed the inhibitory effect of RUNX1 on apoptosis of LPS-mediated CD4+ T and CD19+ B cells. In summary, the RUNX1/FOXP3 axis alleviated immunosuppression in sepsis progression by weakening T and B lymphocyte apoptosis.
Circular plastics technologies: depolymerization of polymers into parent monomers
Authors: Knauer Katrina , Higginson Cody , Liang Yuanzhe , Lee Minjung
Published: August 2023

While most commodity plastics were not designed to easily depolymerize, some common plastics can be broken down into their parent monomers in the presence of heat, pressure, catalysts, and/or solvent. Here, we provide a high-level overview of the depolymerization technologies that have been studied and/or scaled as promising monomer-loop recycling processes for selective plastic waste streams. Namely, commodity plastics that are considered unzippable/depolymerizable include polyethylene terephthalate, polyamides, polymethyl methacrylate, and polystyrene. Monomer-loop recycling technologies are one of several pathways toward a circular economy for plastics.
A bankjegyektől a jegybankokig
Authors: Pfeffer Zsolt
Published: August 2023

In the 17-18th century, during the process of civil transformations, starting from the economic policy based on the era of absolutism, the first central bank regulations appeared in Europe. Mainly the disorganization and crisis of public finances and the need to finance various wars led governments to establish central banks and to provide central banking functions to privately owned banks. The most important issues included the regulation of banknote issuance and legal tender, the management of state funds, the financing of the state debt, as well as the relationship with the state, in other words, the content of central bank independence. Each country followed different paths, and accordingly, the classic and the Prussian models of central bank development can be described based on the different legislative steps. The study presents the main characteristics through the English, German, French, American and Hungarian examples, primarily by characterizing the legislative peculiarities and illuminating the political historical background by applying the methods of comparative law.
Ideal distribution models and the tempo of agricultural development in a windward valley of Hawaiʻi
Authors: Quintus Seth , Rieth Timothy M. , Dye Thomas , Morrison Alexander E. , Filimoehala Christopher W. , Filimoehala Darby , Tulchin Jon , Duarte Trever
Published: August 2023

Across the Pacific, agricultural systems have used two main complementary cultivation regimes: irrigated farming of wet environments and rain-fed cropping of drylands. These strategies have different productive potential and labour needs, which has structured their temporal and spatial distributions. Although these approaches have been studied a great deal at a general level, there has been less work on the local use and significance of these strategies. Here, the authors evaluate ideal distribution models of agricultural activities in the Punalu‘u valley on O‘ahu, Hawai‘i, to assess how habitat suitability changed as a result of infrastructural investment and dynamic environmental, social and demographic change. The results are of relevance for contemporary initiatives to revive Indigenous agricultural systems in Hawai‘i and beyond.
Nicotine Decreases Nerve Regeneration and Pain Behaviors via PTEN and Downstream Inflammation-Related Pathway in Two Rat Nerve Injury Models
Authors: Fang Yehong , Zhang Tingkai , Li Ling , Chen Shanshan , Wang Liangliang , Tang Jinsong , Liao Yanhui
Published: August 2023

Neuropathic pain is stubborn and associated with the peripheral nerve regeneration process. Nicotine has been found to reduce pain, but whether it is involved in the regulation of nerve regeneration and the underlying mechanism are unknown. In this study, we examined the mechanical allodynia thermal hyperalgesia together with the peripheral nerve regeneration after nicotine exposure in two rat neuropathic pain models. In the spinal nerve ligation model, in which anatomic nerve regeneration can be easily observed, nicotine reduced anatomic measures of regeneration as well as expression of regeneration marker growth-associated protein 43 (GAP43). In the tibial nerve crush model, nicotine treatment significantly suppressed GAP43 expression and functional reinnervation as measured by myelinated action potential and electromyography of gastrocnemius. In both models, nicotine treatment reduced macrophage density in the sensory ganglia and peripheral nerve. These effects of nicotine were reversed by the selective α7 nicotinic acetylcholine receptor (nAChR) blocker methyllycaconitine. In addition, nicotine significantly elevated expression of PTEN (the phosphatase and tensin homolog deleted on chromosome 10), a key player in both regeneration and pain. Pharmacological interference of PTEN could regulate GAP43 expression, pain-related behaviors, and macrophage infiltration in a nicotine-treated nerve crush model. Our results reveal that nicotine and its α7-nAChR regulate both peripheral nerve regeneration process and pain though PTEN and the downstream inflammation-related pathway.
Dissociable Neural Mechanisms Underlie the Effects of Attention on Visual Appearance and Response Bias
Authors: Itthipuripat Sirawaj , Phangwiwat Tanagrit , Wiwatphonthana Praewpiraya , Sawetsuttipan Prapasiri , Chang Kai-Yu , Störmer Viola S. , Woodman Geoffrey F. , Serences John T.
Published: August 2023

A prominent theoretical framework spanning philosophy, psychology, and neuroscience holds that selective attention penetrates early stages of perceptual processing to alter the subjective visual experience of behaviorally relevant stimuli. For example, searching for a red apple at the grocery store might make the relevant color appear brighter and more saturated compared with seeing the exact same red apple while searching for a yellow banana. In contrast, recent proposals argue that data supporting attention-related changes in appearance reflect decision- and motor-level response biases without concurrent changes in perceptual experience. Here, we tested these accounts by evaluating attentional modulations of EEG responses recorded from male and female human subjects while they compared the perceived contrast of attended and unattended visual stimuli rendered at different levels of physical contrast. We found that attention enhanced the amplitude of the P1 component, an early evoked potential measured over visual cortex. A linking model based on signal detection theory suggests that response gain modulations of the P1 component track attention-induced changes in perceived contrast as measured with behavior. In contrast, attentional cues induced changes in the baseline amplitude of posterior alpha band oscillations (∼9-12 Hz), an effect that best accounts for cue-induced response biases, particularly when no stimuli are presented or when competing stimuli are similar and decisional uncertainty is high. The observation of dissociable neural markers that are linked to changes in subjective appearance and response bias supports a more unified theoretical account and demonstrates an approach to isolate subjective aspects of selective information processing.

SIGNIFICANCE STATEMENTDoes attention alter visual appearance, or does it simply induce response bias? In the present study, we examined these competing accounts using EEG and linking models based on signal detection theory. We found that response gain modulations of the visually evoked P1 component best accounted for attention-induced changes in visual appearance. In contrast, cue-induced baseline shifts in alpha band activity better explained response biases. Together, these results suggest that attention concurrently impacts visual appearance and response bias, and that these processes can be experimentally isolated.
EVALUATION OF THE QUALITY OF CELLULOSE SEMI-FINISHED PRODUCTS FROM TECHNICAL HEMP AND THE POSSIBILITY OF THEIR FURTHER USE
Authors: Lialina Natalia , Yudicheva Olha , Samoilenko Antonina , Berezovskyi Yurii , Moroz Oleg , Bondar-Pidhurska Oksana , Glebova Alla , Khliebnikova Nataliia , Novikova Vira
Published: August 2023

The article discusses the issues of processing industrial hemp into goods for various functional purposes. Particular attention is paid to the processing of hemp trusts into cellulose-containing semi-finished products, as well as to the analysis of the properties of cellulose-containing fibrous materials obtained from industrial hemp. Based on the results of the study of physical, mechanical and organoleptic characteristics of the obtained cellulose-containing semi-finished products, their suitability for the pulp and paper industry and other sectors of the national economy has been established. The presented research is relevant for the purpose of creating an own raw material base for pulp and paper enterprises and light industry enterprises.
Wicked Heritage Problems: Rethinking Critical Heritage Theory with Contemporary Liminality
Authors: Stevens Alicia V.
Published: August 2023

Since the turn of the twenty-first century, an anxious presentism has taken hold of our social and political reality. This condition rejects the lessons of the past, fears the future, and amplifies crises in the present moment, suspending whole societies in uncertainty. These extraordinary times demand innovation of heritage critique, which lacks a core framework for understanding how heritage interacts with the uncertainty of transition. This paper offers an innovative approach to the problem, arguing for transferring the paradigm of contemporary liminality from political anthropology into heritage studies. Contemporary political anthropologists have adapted liminality’s ritual structure to large-scale phenomena like war, revolution, and extreme transition to understand these experiences at the level of the communities living through them. With an epistemology free from the constraints of secular rationalism, contemporary liminality provides a framework for understanding heritage amid transition that sheds new light on core investigations into the politics of memory and identity. It also leads to the concept of a liminal heritage, heritage that takes on characteristics of its liminal context such as ambivalence, ambiguity, imitation, danger, deception, violence, and creativity.
Effect of zirconia addition on thermal and mechanical properties of poly-methyl methacrylate composites
Authors: Neamah Z. J. , Mahdi S. H.
Published: August 2023

The goal of this study was to improve the mechanical and thermal properties of PolyMethyl Meth Acrylate (PMMA) by adding Zirconia nanoparticles in various weight fraction percentages (0, 1, 1.5, 2, 2.5, 3)%. The cast technique was utilized of to prepare the (PMMA/zirconia) nanocomposites. The thermal and mechanical characterized of (PMMA/zirconia) nanocomposites were studied. Increased zirconia percentages in (PMMA/zirconia) nanocomposites lead to increase thermal conductivity (K), glass transition temperature, specific heat capacity (Cp), effusivity, impact strength, hardness, flexural strength, compressive strength and reduced wear rate, enhancing the thermal and mechanical properties of Poly-Methyl Meth Acrylate (PMMA).
Determination of vitamin D status in singleton and twin gestations using CLIA and LC-MS/MS
Authors: Zgliczyńska Magdalena , Ostrowska Magdalena , Żebrowska Kinga , Szymusik Iwona , Kowalski Konrad , Leszczyńska Dorota , Kosińska-Kaczyńska Katarzyna
Published: August 2023

Objective

Vitamin D plays an important role during pregnancy. The aim was to compare vitamin D status in a group of singleton (SP) and twin pregnancies (TP) using two diagnostic methods: chemiluminescence immunoassay (CLIA) and liquid chromatography with tandem mass spectrometry (LC-MS/MS).

Design

This is a cross-sectional study.

Methods

The study was conducted in the population of SP and TP at the gestational age above 20 + 0 at the Bielanski Hospital in Warsaw, Poland, between October 2020 and January 2023. All patients had their venous blood samples collected and were given an original survey containing questions on demography and vitamin D supplementation.

Results

The study group included 53 Caucasian women with SP and 78 with TP aged from 21 to 47. Considering LC-MS/MS, patients with TP had lower concentrations of 25-hydroxyvitamin D (25(OH)D) than patients with SP. However, no significant difference was observed in the frequency of the occurrence of vitamin D deficiency (25(OH)D < 30 ng/mL). In both groups, the levels obtained with CLIA were significantly lower than in case of LC-MS/MS, however, strongly correlated. The intermethod agreement accounted for 52.4% and the Cohen’s kappa coefficient was 0.142.

Conclusions

The concentration of 25(OH)D in pregnant women depends on the type of gestation (SP/TP) and on the diagnostic methods used (CLIA/LC-MS/MS). Based on LC-MS/MS, the incidence of vitamin D deficiency was low in our group and no differences occurred in its frequency between SP and TP. The intermethod agreement between CLIA and LC-MS/MS on the detection of vitamin D deficiency was low.

Significance statement

This is the first study to compare the concentration of 25(OH)D levels between SP and TP using two methods: CLIA and the gold standard – LC-MS/MS. Based on LC-MS/MS, a low incidence of vitamin D deficiency was observed in our group, in which the vast majority of patients took cholecalciferol supplements. Moreover, there were no differences in its frequency between SP and TP. However, the 25(OH)D level was significantly lower in TP. The intermethod agreement between CLIA and LC-MS/MS on the detection of vitamin D deficiency was low, which is associated with substantial clinical implications.
Virtuoso of Pathophysiological Experiment: to the 100th Anniversary of Academician V. K. Kulagin
Authors: Tsygan V. N. , Mamaeva S. A.
Published: August 2023

Aim. To analyze the contribution of V. K. Kulagin, Doctor of Medical Sciences, Professor of the Department of Pathological Physiology of the Military Medical Academy into development of scientific perspectives concerning the etiology, pathogenesis and therapy of traumatic shock, following thorough analysis of 1950–1980s series of featured publications. We analyzed the general theoretical views of the scientist, his methodological preferences in organizing laboratory experiments, the methodology for developing standard models for conducting experiments, choosing indicators and evaluation criteria. We brought to recollection the proposed by V. K. Kulagin approach to traumatic shock staging and phases relative to the leading pathogenetic factor; highlighted some of the key topics and results of his experimental research related to individual resistance to shock, prerequisites of shock irreversibility and factors complicating the course of traumatic shock.

Conclusion. Theoretical and experimental inventions of V. K. Kulagin are relevant to the present day and are of great importance for further progress of medical science.
Postoperative Neurocognitive Disorders: the Legacy of Almost 400 Years of History (Review)
Authors: Berikashvili L. B. , Kadantseva K. K. , Ermokhina N. V. , Yadgarov M. Ya. , Makarevich D. G. , Smirnova A.  V. , Likhvantsev V. V.
Published: August 2023

The history of the study of postoperative neurocognitive disorders (PND) looks as a long and thorny path of more than 400 years. Despite all accumulated data on PND risk factors and outcomes, there’s still no complete understanding of the etiology and pathogenesis of this complication. Moreover, current anesthesiologyresuscitation practice still faces challenges and has pending questions in diagnosis and classification of postoperative neurocognitive disorders.

The purpose of the review. To contemplate the evolution in the perceptions of the international medical community (IMC) regarding diagnostic approaches and algorithms in PND management. The review covers the history of development of such PND concepts as postoperative delirium, postoperative cognitive dysfunction, emergence agitation and emergence delirium. Also, the pre-existing and current international classifications of postoperative neurocognitive disorders are discussed in chronological order, supplemented by the analysis of their strengths and weaknesses. The paper also delves into current viewpoints concerning the etiology of particular postoperative neurocognitive disorders, and PND potential relevance for postoperative outcomes.

Conclusion. Current algorithms and modalities used for PND diagnosis, are novel but yet not ultimate for IMC in the context of continuous progress in medical practice. Early postoperative neurocognitive disorders remain the most poorly studied phenomena with no approved definitions and diagnostic modalities to identify. It is probably the time for IMC to undertake a joint effort to find answers to current unresolved questions regarding postoperative neurocognitive disorders.
Self-government of medical professions in Ukraine. Current state and legal perspective
Authors:   Taras Shevchenko Kyiv National University, Ukraine, Knyazevych N.V.
Published: August 2023

Purpose - to study the current state and legal prospects of self-government of medical professions in Ukraine. Materials and methods. During the research, a number of scientific methods were applied, including general scientific methods, abstraction method, etc. Results and conclusions. The article considers attempts to introduce self-government of medical professions in Ukraine and their shortcomings. The assessment is given to organizations that Unite representatives of medical professions in Ukraine now. Their legal status and role in the functioning of the modern healthcare system are determined. the latest draft law that was considered in the context of introducing self-government of medical professions in Ukraine is analyzed and evaluated. Similar organizations abroad are considered, and their advantages are determined. Measures to solve the problems that exist at the time of writing are proposed. No conflict of interests was declared by the author.
Antiviral therapy for patients with decompensated cirrhosis due to chronic hepatitis C: pros and cons
Authors:   Bogomolets National Medical University, Kyiv, Ukraine, Zaitsev I.A.
Published: August 2023

The effectiveness of hepatitis C treatment in patients with decompensated cirrhosis is about 90%. Further prognosis of the disease depends on liver cirrhosis. Since in Ukraine liver transplantation is not available to most patients, the question of the economic feasibility of treating such patients remains open. According to the literature data, the survival rate in patients with cirrhosis and baseline MELD 10-15 is 96.0%, 93.6%, 89.7% within, respectively, 1, 2, 3 years after PPD treatment, and in patients with MELD 16 - 85.9%, 82.4%, 71.7%, respectively. The overall mean short-term change in MELD was less than one point, and a clinically significant improvement of 3 MELD points occurred in only 24% of patients. According to other studies, an improvement within 2 points of MELD occurs in 40% of patients with decompensated cirrhosis with SVR. In the remaining 60%, the condition does not change or worsens, i.e. antiviral therapy acquires the features of a palliative therapy that improves the quality of life of patients, but does not affect the outcome of the disease. The feasibility of prescribing antiviral therapy in patients with decompensated liver cirrhosis can be determined using the calculator, which assesses the likelihood of reaching CPT-A and the risk of death during the first year of follow-up. No conflict of interests was declared by the authors.
Peculiarities of nursing care for palliative patients
Authors:   Separate subdivision Rivne regional organization of the PO Ukrainian League for the Development of Palliative and Hospice Care, Ukraine, Vengryn N.A.
Published: August 2023

In the article the peculiarities of nurses’ activities while palliative care are presented, and the essential components of their professionalism are highlighted. No conflict of interests was declared by the author.
Current issues of nurses training in palliative care
Authors:   Cherkasy Medical Academy, Ukraine, Gubenko I.Ya. , Chernyshenko T.I. ,   Cherkasy Medical Academy, Ukraine, Brazaliy L.P. ,   Cherkasy Medical Academy, Ukraine
Published: August 2023

Purpose - to improve the quality of nurses training at the undergraduate and postgraduate levels by developing students' motivation, creating and improving curricula and introducing new methods of teaching palliative and hospice care. Materials and methods. Development of the teaching methodology for the palliative care nurses training; organization of the corresponding nurses training at the undergraduate and postgraduate levels; organization of the student volunteer movement to develop work motivation in the field of palliative medicine. Results. Every effort should be made to help and ensure a decent quality of life, to alleviate pain and suffering for terminally ill patients and their loved ones. Therefore, qualified nurses education is one of the priorities for successful development of palliative care. Conclusions. Thus, it is necessary: to shape students’ motivation through better awareness of future professional activity in the field of palliative care; to improve the quality of palliative care and motivate health professionals to study and work, there should be an introduction to the nomenclature of specialties of nurses specialization and specialization «Palliative Medicine»; to introduce the obligatory cycle on palliative care in the list of students’ practices at health facilities for terminally ill patients; to increase the number of hours devoted to studying this discipline and introduce the topic of palliative and hospice care for children. No conflict of interests was declared by the authors.
Medical and social consequences of the safety problems of oncological radiology
Authors:   Kharkiv National Medical University, Ukraine, Pylypenko M.I. , Stadnyk L.L. ,   Grigoriev Institute for medical Radiology of the NAMS of Ukraine, Rygan M.M. ,   Medical Center Clinic of modern orthopedics, Kyiv, Ukraine, Skaleckyj Ju.M. ,   National Commission for Radiation Protection of Ukraine, Kyiv, Shalyopa O.Ju. ,   Grigoriev Institute for medical Radiology of the NAMS of Ukraine
Published: August 2023

The relevance of the problem of patient safety in oncoradiology in Ukraine and other countries has been substantiated. The purpose - is to assess the safety of patients receiving radiation therapy and the magnitude of the health and social consequences of human error in this area. Materials and methods. The material of the study was the results of international TLD audit (IAEA/WHO) of the dosimetry quality during procedures on cobalt telegram devices in Ukraine as well as the international and domestic regulatory framework on safety of the radiotherapy care, and scientific publications of domestic and foreign specialists on patient safety. The methods of the research: statistical, analytical, bibliographic, systems approach. Results. By the example of radiotherapy using the results of the international IAEA/WHO program on the TLD audit of the quality of the dosimetric calibration of the remote gamma-therapy units in Ukraine in 1998-2014, an attempt has been made to estimate the scale of medico-social consequences of the underestimation of medical errors in oncoradiology. The problems of regulatory nature of medical errors in oncoradiology had been tentatively identified. Conclusions. The problem of medical errors in the treatment of cancer patients with radiation oncology in Ukraine is extremely topical. Usually the problems of errors in oncoradiology are considered in the organizational, methodological, personnel and technical aspects, while the medico-social consequences of the problem are not covered. In the optimistic scenario, about 10,000 cancer patients for a year may suffer from dose-related errors alone, while in the pessimistic scenario the number may be as high as 15,000 over the same period. There are legal issues to be clarified in oncoradiology for patient safety reasons. The first priority for improving patient safety in oncoradiology is to record and analyze defects in radiotherapy and their consequences. No conflict of interests was declared by the authors.
The geriatric component of palliative care and the state of medical and social care to elderly people temporarily displaced from the occupied territories
Authors:   D.F. Chebotaryov Institute of Gerontology of the NAMS of Ukraine, Kyiv, Vyalykh T.I. , Chaikovska V.V. ,   D.F. Chebotaryov Institute of Gerontology of the NAMS of Ukraine, Kyiv,   Shupyk National University of Healthcare of Ukraine, Kyiv, Velichko N.M. ,   D.F. Chebotaryov Institute of Gerontology of the NAMS of Ukraine, Kyiv, Tolstykh V.A. ,   D.F. Chebotaryov Institute of Gerontology of the NAMS of Ukraine, Kyiv, Moskalyuk S.V. ,   D.F. Chebotaryov Institute of Gerontology of the NAMS of Ukraine, Kyiv
Published: August 2023

The paper presents the state of provision and needs for medical and social care and psychological support to elderly people temporarily displaced from the conflict zone in the East of the country. A survey of 300 elderly people, medical and social specialists and statistical processing of these data was conducted. It is shown that the socio-psychological characteristics of temporarily displaced elderly people, the peculiarities of their social adaptation, insufficient funding and low level of medical and social care cause inadequate living conditions and require the establishment of a system of care and training of care staff. Curricula for training of medical, social specialists and volunteers on acquisition of theoretical knowledge and practical skills on care of elderly people are developed and implemented. No conflict of interests was declared by the authors.
HUBUNGAN PANJANG-PANJANG, POLA PERTUMBUHAN DAN KONDISI IKAN NYALIAN, Barbodes binotatus (VALENCIENNES, 1842) DI EMPAT DANAU DI PULAU BALI
Authors: Parawangsa I Nyoman Yoga , Tampubolon Prawira Atmaja , Pertami Nyoman Dati
Published: August 2023

The relationship between length type, length-weight relationship and condition factors is an initial approach to fisheries management. Research related to that issue on spotted barb (Barbodes binotatus) in four lake ecosystems in Bali has never been published. This study aims to reveals information related to the relationship of length character, growth patterns and conditions of B. binotatus in four lake ecosystems in Bali. Fish sampling was carried out from August 2017 to July 2018 at Tamblingan Lake, Buyan Lake, Beratan Lake and Batur Lake which were carried out alternately. The results of this study revealed that the total length (TL), fork length (FL) and standard length (SL), each type of measurement can be used to estimate the weight of B. binotatus, but standard length was the most suitable type of measurement in estimating weights. This fish species has a positive allometric growth pattern (b>3) with an estimated condition that is in good condition.
POTENSI INVASIF IKAN ZEBRA CICHLID (Amatitlania nigrofasciata Günther, 1867)DI DANAU BERATAN, BALI DITINJAU DARI ASPEK BIOLOGINYA
Authors: Sentosa Agus Arifin , Wijaya Danu
Published: August 2023

Danau Beratan yang terletak di kawasan Bedugul, Bali telah terintroduksiikan zebra cichlid (Amatitlania nigrofasciata Günther, 1867) secara tidak sengaja. Tujuan penelitian adalah untuk mengetahui potensi ikan zebra sebagai ikan asing invasif di Danau Beratan berdasarkan kajian pada beberapa aspek biologinya. Penelitian dilakukan dengan metode survei lapang di Danau Beratan, Bali pada bulan Mei, Juli dan Oktober 2011. Contoh ikan diperoleh menggunakan jaring insang percobaan dan jaring tarik. Analisis data meliputi hubungan panjang berat, faktor kondisi, parameter pertumbuhan, kebiasaan makanan dan aspek reproduksi ikan. Hasil penelitian menunjukkan ikan zebra mendominasi hasil penangkapan. Ikan tersebut memiliki faktor kondisi yang baik dengan nilai laju pertumbuhan tahunan (K) yang tinggi, bersifat generalis dalam memanfaatkan sumber daya makanan dan matang gonad pada ukuran panjang yang kecil. Karakteristik biologi inimengindikasikan ikan tersebut memiliki potensi invasif yang cukup tinggi. Lake Beratanislocated inBedugul, Balihas been an unintentional introduction ofzebracichlid(Amatitlania nigrofasciataGünther, 1867). The aim of this research was to determine thepotential ofzebra cichlid becomeinvasivealienfish speciesinLake Beratanbasedonseveralbiological aspects.The study was carried outby field surveymethods in Lake Beratan, Bali on May, JulyandOctober 2011. Fish samples was obtained usingexperimentalgillnetsandmodification ofseine nets. Data analysis included the lengthweightrelationship, conditionfactor, growth parameters, foodhabitsand its reproduction aspects. The results showedthat zebracichliddominatethe experimental catchin LakeBeratan. Analysis showedthese fishhavea goodconditionwith ahigh growth rate, have a generalist characteristic in exploitingthe natural food resourcesandmatureat small length size. A reviewforseveral biological aspects ofthe zebra cichlidshowedthatfishhavea highinvasivepotentialinLake Beratan.
Bird surveys at windfarms in the Eastern Cape, South Africa
Authors: Parker Vincent
Published: August 2023

Bird surveys were conducted at four windfarm sites and four control sites in the Eastern Cape, South Africa. Numbers of the Blue Crane Grus paradisea decreased at three out of four windfarm sites after commencement of windfarm activities and did not decrease at any of the control sites. Numbers for several bird species of the fynbos and grassland tended to increase at windfarm sites after commencement of windfarm activities, and did not increase at the control sites.
Ujaran Kebencian Anggota DPRD Kabupaten Bantul Periode 2019-2024
Authors: Ardiansyah Pribadi Denny , Qodir Zuly
Published: August 2023

Penelitian ini memiliki tiga tujuan, yaitu mengidentifikasi bentuk ujaran kebencian yang dilontarkan salah satu anggota DPRD Kabupaten Bantul, peran Badan Kehormatan DPRD Kabupaten Bantul dalam menangani permasalahan serta sanksi yang diberikan pada anggota DPRD tersebut. Pene­­liti menggu­nakan metode kualitatif deskriptif dengan data sekunder yang terbagi atas literatur, media online dan internet, serta dokumen dari DPRD Kabupaten Bantul. Hasil penelitian menunjukkan bahwa anggota DPRD Kabupaten Bantul telah melakukan ujaran kebencian, dengan bentuk pencemaran nama baik sukarelawan covid-19 di Kabupaten Bantul. Untuk memper­tang­gungjawabkan tindakan­nya, anggota DPRD Kabupaten Bantul tersebut telah dipanggil oleh Badan Kehormatan DPRD Kabupaten Bantul. Akhirnya, untuk menyelesaikan perkara anggota DPRD Kabu­paten Bantul dengan pertimbangan Badan Kehormatan DPRD Kabupaten Bantul meminta maaf secara terbuka kepada selu­ruh sukarelawan covid-19 di Kabupaten Bantul.
The Strategy of Tuan Guru In The Election of The West Lombok Legislative
Authors: Solihan Solihan , Hafis Bin Amat Simin Mohamad , Sukri Muhammad
Published: August 2023

The purpose of this research is to describe the strategy of Tuan Guru in the election of the West Lombok legislature. The research question is: What are the factors behind Tuan Guru’s entry into the world of practical politics? What is the Tuan Guru strategy in politics? What was the significant impact on the development of West Lombok in the Tuan Guru era following politics? This research uses qualitative methods based on phenomena. The finding in this research is the purpose of Tuan Guru’s involvement in politics are power and sources of power, positional power, and personal power. As for the strategy of Tuan Guru to garner support as a candidate for the legislature or executive, it is utilizing a network of students and alumni, a family network, fellow Tuan Guru, majlis ta'lim to conduct political socialization. And the last, the significant impact on the development of  West Lombok in the Tuan Guru era following politics, bringing economic growth, politics, and democracy.
Studi Komparasi Prosedur Pencatatan Perkawinan di Indonesia dan Malaysia
Authors: Cahyani Safira Putri , Siti Winariyah Siti , Andriyani Wiwik , Pangestu Drajat Samudra , Ulya Zakiyatul
Published: August 2023

Mengingat begitu banyaknya hal yang akan berpengaruh dari dicatatkannya suatu perkawinan, maka tak heran jika pencatatan perkawinan menjadi perhatian bagi masyarakat hingga pemerintah. Pemerintah yang memiliki wewenang dalam membuat suatu peraturan juga turut ikut andil dalam mengefektivitaskan suatu pencatatan perkawinan dalam masyarakat, salah satunya adalah di Indonesia. Di Indonesia sendiri telah diatur tentang bagaimana prosedur pencatatan perkawinan yang telah termuat dalam Peraturan Menteri Agama Nomor 20 Tahun 2019 tentang Pencatatan Pernikahan. Hal ini menjadi bukti bahwa pemerintah Indonesia berusaha untuk menjaga hak-hak konstitusional rakyatnya. Hal serupa juga diterapkan oleh negara tetangganya, yakni Malaysia. Di Malaysia terdapat suatu peraturan yang mengatur tentang prosedur pencatatan perkawinan, yakni dalam Akta Undang-Undang Keluarga Islam (Wilayah-Wilayah Persekutuan) 1984. Hal ini membuktikan bahwa kedua negara tersebut turut memberikan perhatiannya terhadap pentingnya pencatatan sebuah perkawinan. Tujuan dari penelitian ini untuk membandingkan seperti apa prosedur pencatatan perkawinan dari kedua negara tersebut. Metode penelitian yang digunakan oleh peneliti yaitu Library Research atau studi pustaka. Salah satu persamaan dari kedua peraturan tersebut adalah sama-sama menyatakan bahwa pencatatan perkawinan bukan merupakan syarat sah suatu perkawinan, akan tetapi merupakan bentuk legalisasi hukum bagi perkawinan itu sendiri. Selain itu, keduanya juga memiliki perbedaan dalam mendaftarkan kehendak nikah, yang mana di Indonesia dilakukan selambatnya 10 hari sebelum pernikahan, sedangkan di Malaysia 7 hari sebelum pernikahan.
Caracterización de las prácticas laborales en el turismo de naturaleza en el Distrito de Buenaventura 2022, aportes desde el turismo comunitario
Authors: Paredes Prieto Jakeline , Reyna López Yuli Carolina , Castillo Cuero Jeferson Alexander
Published: August 2023

La actual investigación hace parte del macro proyecto denominado: “Apropiación del conocimiento en seguridad y salud en el trabajo en el sector del turismo de naturaleza, Distrito de Buenaventura”, el apartado que se abordará en este espacio tiene como objetivo caracterizar el estado del arte de las condiciones de vida y trabajo de los actores informales vinculados al turismo de naturaleza en el contexto del turismo comunitario y el trabajo informal, haciendo énfasis en la gestión de la seguridad y salud laboral, así como sus principales desafíos. Buenaventura representa el territorio de estudio desde el cual se plantea el panorama de análisis, este Distrito se ha posicionado como un destino turístico pionero en las prácticas de turismo de naturaleza las cuales se desarrollan principalmente desde la informalidad o la organización comunitaria.
Donde las actividades se ejecutan sin tener en cuenta ninguna estrategia de prevención de riesgos. Para el progreso de esta investigación se empleó una metodología cualitativa de corte exploratoria, la cual estará enfocada en la revisión documental que permita identificar las circunstancias de vida y trabajo de las comunidades que practican dentro de sus territorios el turismo de naturaleza, así como las principales características del Distrito de Buenaventura respecto a su gestión de la seguridad y salud laboral en el sector turístico.