bluuebunny/crossref_metadata_2025 huggingface dataset:
Stacking Yield Prediction of Package-on-Package Assembly Using Advanced Uncertainty Propagation Analysis: Part I Stochastic Model Development
Authors: Wei Hsiu-Ping , Yang Yu-Hsiang , Han Bongtae
Published: May 2019

A comprehensive stochastic model is proposed to predict Package-on-Package (PoP) stacking yield loss. The model takes into account all pad locations at the stacking interface while considering the statistical variations of the warpages and the solder ball heights of both top and bottom packages. The goal is achieved by employing three statistical methods: (1) an advanced approximate integration-based method called eigenvector dimension reduction (EDR) method to conduct uncertainty propagation (UP) analyses, (2) the stress-strength interference (SSI) model to determine the noncontact probability at a single pad, and (3) the union of events considering the statistical dependence to calculate the final yield loss. In this first part, theoretical development of the proposed stochastic model is presented. Implementation of the proposed model is presented in a companion paper.
Progressive Failure Monitoring of Fiber-Reinforced Metal Laminate Composites Using a Nondestructive Approach
Authors: Carmi Rami , Wisner Brian , Vanniamparambil Prashanth A. , Cuadra Jefferson , Bussiba Arie , Kontsos Antonios
Published: May 2019

Fiber-reinforced metal laminate (FRML) composites are currently used as a structural material in the aerospace industry. A common FRML, glass layered aluminum reinforced epoxy (Glare), possesses a set of mechanical properties which was achieved by designing its layup structure to combine metal alloy and fiber-reinforced polymer phases. Beyond static and dynamic mechanical properties at the material characterization phase, however, the need exists to develop methods that could assess the evolving material state of Glare, especially in a progressive failure context. This paper presents a nondestructive approach to monitor the damage at the material scale and combine such information with characterization and postmortem evaluation methods, as well as data postprocessing to provide an assessment of the failure process during monotonic loading conditions. The approach is based on multiscale sensing using the acoustic emission (AE) method, which was augmented in this paper in two ways. First, by applying it to all material components separately in addition to actual Glare specimens. Second, by performing testing and evaluation at both the laboratory scale as well as at the scale defined inside the scanning electron microscopy. Such elaborate testing and nondestructive evaluation results provided the basis for the application of digital signal processing and machine learning methods which were capable to identify data trends that are shown to be correlated with the evolution of failure modes in Glare.
Acoustic testing techniques for replicating in-flight dynamic loads
Authors: Cohen Kobi J. , Raveh Daniella E.
Published: May 2019

Modern weapon systems used on combat aircraft have complex electronic assemblies that are required to operate in a challenging dynamic environment throughout their life cycle. Among the various sources of excitation, aerodynamic noise is considered most significant. The paper presents vibroacoustic measurements from a captive flight and attempts to replicate them in acoustic laboratory testing. The question of interest is which testing method, concerning configuration and control scheme, is the most adequate to accurately simulate the vibratory response of inner assemblies to flight loads. The paper examines acoustic test methods in a reverberant chamber. The tested article is a subsystem of a weapon system that includes electrical assemblies integrated inside a structural shell. Two test configurations are compared; an enclosed configuration, in which the subsystem is tested inside its structural shell, and an exposed configuration, in which the subsystem is directly exposed to acoustic excitation. Acceleration measurements show that when excited by in-flight acoustic levels, the acceleration responses of the exposed subsystem are significantly lower than those measured in flight. For the enclosed configuration, although the acoustic levels inside the envelope are attenuated by the structure, the resulting accelerations are significantly higher and closer to those of flight.
Evolutionary parallelisms of pectoral and pelvic network-anatomy from fins to limbs
Authors: Esteve-Altava Borja , Pierce Stephanie E. , Molnar Julia L. , Johnston Peter , Diogo Rui , Hutchinson John R.
Published: May 2019

Anatomical organization of pectoral and pelvic appendages evolved in parallel during the fins-to-limbs transition.
Metabolic reprogramming toward oxidative phosphorylation identifies a therapeutic target for mantle cell lymphoma
Authors: Zhang Liang , Yao Yixin , Zhang Shaojun , Liu Yang , Guo Hui , Ahmed Makhdum , Bell Taylor , Zhang Hui , Han Guangchun , Lorence Elizabeth , Badillo Maria , Zhou Shouhao , Sun Yuting , Di Francesco M. Emilia , Feng Ningping , Haun Randy , Lan Renny , Mackintosh Samuel G. , Mao Xizeng , Song Xingzhi , Zhang Jianhua , Pham Lan V. , Lorenzi Philip L. , Marszalek Joseph , Heffernan Tim , Draetta Giulio , Jones Philip , Futreal Andrew , Nomie Krystle , Wang Linghua , Wang Michael
Published: May 2019

Targeting oxidative phosphorylation overcomes ibrutinib resistance in mantle cell lymphoma.
HBEGF
+
macrophages in rheumatoid arthritis induce fibroblast invasiveness
Authors: Kuo David , Ding Jennifer , Cohn Ian S. , Zhang Fan , Wei Kevin , Rao Deepak A. , Rozo Cristina , Sokhi Upneet K. , Shanaj Sara , Oliver David J. , Echeverria Adriana P. , DiCarlo Edward F. , Brenner Michael B. , Bykerk Vivian P. , Goodman Susan M. , Raychaudhuri Soumya , Rätsch Gunnar , Ivashkiv Lionel B. , Donlin Laura T.
Published: May 2019

Macrophages promote fibroblast invasiveness and demonstrate variable response to anti-inflammatory medications in patients with rheumatoid arthritis.
Discovery of short-course antiwolbachial quinazolines for elimination of filarial worm infections
Authors: Bakowski Malina A. , Shiroodi Roohollah Kazem , Liu Renhe , Olejniczak Jason , Yang Baiyuan , Gagaring Kerstin , Guo Hui , White Pamela M. , Chappell Laura , Debec Alain , Landmann Frédéric , Dubben Bettina , Lenz Franziska , Struever Dominique , Ehrens Alexandra , Frohberger Stefan J. , Sjoberg Hanna , Pionnier Nicolas , Murphy Emma , Archer John , Steven Andrew , Chunda Valerine C. , Fombad Fanny F. , Chounna Patrick W. , Njouendou Abdel J. , Metuge Haelly M. , Ndzeshang Bertrand L. , Gandjui Narcisse V. , Akumtoh Desmond N. , Kwenti Tayong D. B. , Woods Ashley K. , Joseph Sean B. , Hull Mitchell V. , Xiong Wen , Kuhen Kelli L. , Taylor Mark J. , Wanji Samuel , Turner Joseph D. , Hübner Marc P. , Hoerauf Achim , Chatterjee Arnab K. , Roland Jason , Tremblay Matt S. , Schultz Peter G. , Sullivan William , Chu Xin-Jie , Petrassi H. Michael , McNamara Case W.
Published: May 2019

This study identifies oral, highly efficacious antiwolbachial compounds to cure filarial infections in mice.
Dual oncogene excision is greater than the sum of its parts
Authors: Montero Joan
Published: May 2019

Ablation of EGFR and c-RAF in combination is effective against aggressive pancreatic tumors.
Tinkering with the vasopressin pathway in autism
Authors: Forgeot d’Arc Baudouin , Mottron Laurent , Elsabbagh Mayada , Jacquemont Sébastien
Published: May 2019

Two clinical trials targeting the vasopressin pathway in autism highlight continuing challenges in outcome measures and statistical power.
A Hydrophobic Network: Intersubunit and Intercapsomer Interactions Stabilizing the Bacteriophage P22 Capsid
Authors: Asija Kunica , Teschke Carolyn M.
Published: May 2019

Similarities in assembly reactions and coat protein structures of the dsDNA tailed phages and herpesviruses make phages ideal models to understand capsid assembly and identify potential targets for antiviral drug discovery. The coat protein E-loops of these viruses are involved in both intra- and intercapsomer interactions. In phage P22, hydrophobic interactions peg the coat protein subunits together within a capsomer, where the E-loop hydrophobic residue W61 of one subunit packs into a pocket of hydrophobic residues I366 and W410 of the adjacent subunit. W61 also makes hydrophobic interactions with A91 and L401 of a subunit in an adjacent capsomer. We show these intra- and intercapsomer hydrophobic interactions form a network crucial to capsid stability and proper assembly.
Draft Genome Sequence of
Agarivorans
sp. Strain Toyoura001, Isolated from an Abalone Gut
Authors: Itoh Hideomi , Kawano Keisuke , Kihara Minoru
Published: May 2019

Agarivorans
sp. strain Toyoura001 is a bacterium isolated from the gut of a wild abalone,
Haliotis discus hannai
. Here, we report the draft genome sequence of strain Toyoura001, which consists of 60 contigs comprising 4.67 Mb and 4,257 protein-coding genes.
Complete Genome Sequence of
Agrobacterium fabrum
Strain 1D159
Authors: Huo Naxin , Gu Yong , McCue Kent F. , Alabed Diaa , Thomson James G.
Published: May 2019

This work reports the draft genome sequence of
Agrobacterium fabrum
strain 1D159 (also known as ATCC strain 27912). The assembled genome is composed of a 2,861,352-bp circular chromosome, a 2,058,040-bp linear chromosome, a 519,735-bp AT plasmid, and the 223,394-bp Ti virulence plasmid.
Draft Genome Sequence of a Rare Israeli Clinical Isolate of Burkholderia pseudomallei
Authors: Israeli Ofir , Cohen-Gihon Inbar , Brosh-Nissimov Tal , Weiss Shay , Zvi Anat , Beth-Din Adi , Shifman Ohad , Israeli Ma’ayan , Elia Uri , Lazar Shirley , Bar-Haim Erez , Cohen Ofer , Chitlaru Theodor
Published: May 2019

We report here the draft genome sequence ofBurkholderia pseudomalleiMAA2018. This highly virulent strain was isolated in 2018 from the first melioidosis case in Israel associated with recreational travel to Goa, India.
Genome Sequence of
Lecanicillium fungicola
150-1, the Causal Agent of Dry Bubble Disease
Authors: Banks Alice M. , Aminuddin Farhana , Williams Katherine , Batstone Thomas , Barker Gary L. A. , Foster Gary D. , Bailey Andy M.
Published: May 2019

The fungus
Lecanicillium fungicola
causes dry bubble disease in the white button mushroom
Agaricus bisporus
. Control strategies are limited, as both the host and pathogen are fungi, and there is limited understanding of the interactions in this pathosystem.
Draft Genome Sequences of the Type Strains of Six
Macrococcus
Species
Authors: Mazhar Shahneela , Altermann Eric , Hill Colin , McAuliffe Olivia
Published: May 2019

We report here the draft genome sequences of
Macrococcus bovicus
ATCC 51825
T
,
Macrococcus carouselicus
ATCC 51828
T
,
Macrococcus equipercicus
ATCC 51831
T
,
Macrococcus brunensis
CCM4811
T
,
Macrococcus hajekii
CCM4809
T
, and
Macrococcus lamae
CCM4815
T
. The availability of the genome sequences of these species will enable cross-species comparison, which could lead to a more comprehensive understanding of organisms of the
Macrococcus
genus.
Complete Genome Sequence of Serratia marcescens Siphophage Scapp
Authors: Koehler Brian T. , Hopson Helena , Kongari Rohit , Bonasera Rachele , Hernandez-Morales Adriana C. , Liu Mei
Published: May 2019

Serratia marcescensis an opportunistic pathogen that typically infects the respiratory and urinary tract, with the majority of cases being hospital acquired. The study ofS. marcescensphages may help control drug-resistantS. marcescensstrains.
Complete Genome Sequence of Serratia marcescens Siphophage Serbin
Authors: Williams Eric A. , Hopson Helena , Rodriguez Andrea , Kongari Rohit , Bonasera Rachele , Hernandez-Morales Adriana C. , Liu Mei
Published: May 2019

Serratia marcescensis an opportunistic human pathogen that is known to cause hospital-acquired respiratory and urinary tract infections. Here, we announce the complete genome sequence and the features ofS. marcescensphage Serbin.
Draft Genome Sequence of Clinical Isolate
Alcaligenaceae
sp. Strain 429
Authors: Zilliox Michael J. , Schreckenberger Paul C. , Putonti Catherine
Published: May 2019

Here, we present the 3.53-Mb genome for
Alcaligenaceae
sp. strain 429, isolated from a patient with unknown etiology. While the 16S rRNA gene most closely resembles
Paenalcaligenes
species, average amino acid identity (AAI) analysis did not meet the threshold to classify our strain as a species of this family.
Endobronchial, laryngeal and mediastinal melanoma: a rare constellation of metastatic disease
Authors: Martinez Pena Grace Nabila , Jiang Chuan
Published: May 2019

A 45-year-old man presents with acute respiratory failure. Imaging revealed a left mainstem endobronchial mass with subcarinal lymphadenopathy, but no other evidence of a primary tumour. An incidental laryngeal nodule was found during bronchoscopy. Biopsies of this lesion by nasopharyngoscopy and subcarinal lymph nodes via mediastinoscopy were performed. Histopathological and immunohistochemical examination showed evidence of melanoma in both samples. Mutational analysis identified the presence of a BRAFV600Emutation. The patient underwent bronchoscopic ablation of the left mainstem endobronchial tumour with laser therapy followed by initiation of encorafenib and binimetinib combination therapy. The patient remains alive at 4 months after initial presentation of disease. This case adds to the body of literature highlighting the clinical heterogeneity and challenges of the management of metastatic pulmonary melanoma. To the best of our knowledge, this simultaneous constellation of metastasis has not been described before.
Non-traumatic ruptured splenic abscess presenting with pneumoperitoneum in an immunocompetent patient: a diagnostic dilemma
Authors: Agarwal Nitin , Sharma Ashish , Garg Gaurav
Published: May 2019

Splenic abscess is a rare life-threatening clinical entity. There are only a handful of reported cases of spontaneous splenic abscess rupture with pneumoperitoneum. Rupture of splenic abscess associated with gas-producing pathogens may lead to pneumoperitoneum. We hereby report the case of a ruptured splenic abscess with pneumoperitoneum in a young immunocompetent woman masquerading as hollow viscus perforation peritonitis. Ruptured splenic abscess should be kept in mind for treating surgeons as a differential diagnosis of pneumoperitoneum or peritonitis, particularly for immunocompromised patients.
Post-traumatic wind swept deformity: five volar carpometacarpal dislocations
Authors: Mane Prajwal P , Bhat Anil K , Acharya Ashwath
Published: May 2019

Carpometacarpal (CMC) joint dislocation other than thumb are rare injuries and can be easily missed. These injuries account for <1% of all hand injuries and are frequently overlooked or missed. CMC dislocations can occur either in dorsal or volar direction and be associated with fractures. However, dorsal dislocation is more commonly encountered than volar dislocation. Volar CMC joint dislocations are rare and need a high level of suspicion for diagnosing and prevention of complications. We present a 36-year-old woman with post-traumatic neglected volar dislocation of all the five CMC joints leading to a windswept deformity of the hand.
Aortoenteric fistula: a rare but critical cause of small bowel bleeding discovered on capsule endoscopy
Authors: Davie Matt , Yung Diana E , Plevris John N , Koulaouzidis Anastasios
Published: May 2019

A 78-year-old man attended for outpatient capsule endoscopy, to investigate a recent history of unexplained small bowel bleeding. His previous medical history included an abdominal aortic aneurysm repair 6 years ago. Soon after capsule ingestion, he experienced sudden onset abdominal pain and collapsed on hospital grounds. He was rapidly transferred to the emergency department as he was haemodynamically unstable, and a significant per rectum (PR) bleed was found on examination. The patient was quickly stabilised following fluid resuscitation. CT angiography was performed which did not show active bleeding. However, use of the real-time capsule viewer indicated a profuse active jejunal bleed originating from the aortic graft, suggestive of an aortoenteric fistula. The patient underwent emergency endovascular cuff placement, and subsequent endovascular abdominal aortic stent grafting, to good effect.
Anti-HMGCR myopathy presenting with acute systolic heart failure
Authors: Pitlick Mitchell , Ernste Floranne
Published: May 2019

Necrotising autoimmune myopathy (NAM) is an immune-mediated myopathy that may be associated with statin use, malignancy or an autoimmune connective tissue disease, but it can also be idiopathic. Anti-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) myopathy is an extremely rare side effect of statin use, occurring in approximately 2–3 out of every 100 000 patients who use statins. Patients typically present with subacute proximal muscle weakness and creatine kinase levels >10 times the upper limit of normal. The diagnosis is suggested by muscle biopsy showing necrotic fibres with minimal inflammation along with positive anti-HMGCR antibodies. Treatment nearly always requires multiple immunosuppressive agents, the earlier use of which is associated with improved outcomes. Reports of statin-induced NAM leading to heart failure are limited. We present the case of a 69-year-old woman with statin-induced NAM who presented with acute systolic heart failure. Early initiation of high-dose corticosteroids and IVIG resulted in significant improvement in her symptoms.
Diagnosis and management of sensory polyneuropathy
Authors: Gwathmey Kelly Graham , Pearson Kathleen T
Published: May 2019

Sensory polyneuropathies, which are caused by dysfunction of peripheral sensory nerve fibers, are a heterogeneous group of disorders that range from the common diabetic neuropathy to the rare sensory neuronopathies. The presenting symptoms, acuity, time course, severity, and subsequent morbidity vary and depend on the type of fiber that is affected and the underlying cause. Damage to small thinly myelinated and unmyelinated nerve fibers results in neuropathic pain, whereas damage to large myelinated sensory afferents results in proprioceptive deficits and ataxia. The causes of these disorders are diverse and include metabolic, toxic, infectious, inflammatory, autoimmune, and genetic conditions. Idiopathic sensory polyneuropathies are common although they should be considered a diagnosis of exclusion. The diagnostic evaluation involves electrophysiologic testing including nerve conduction studies, histopathologic analysis of nerve tissue, serum studies, and sometimes autonomic testing and cerebrospinal fluid analysis. The treatment of these diseases depends on the underlying cause and may include immunotherapy, mitigation of risk factors, symptomatic treatment, and gene therapy, such as the recently developed RNA interference and antisense oligonucleotide therapies for transthyretin familial amyloid polyneuropathy. Many of these disorders have no directed treatment, in which case management remains symptomatic and supportive. More research is needed into the underlying pathophysiology of nerve damage in these polyneuropathies to guide advances in treatment.
Association between Apgar scores of 7 to 9 and neonatal mortality and morbidity: population based cohort study of term infants in Sweden
Authors: Razaz Neda , Cnattingius Sven , Joseph KS
Published: May 2019

Objective

To investigate associations between Apgar scores of 7, 8, and 9 (versus 10) at 1, 5, and 10 minutes, and neonatal mortality and morbidity.

Design

Population based cohort study.

Setting

Sweden.

Participants

1 551 436 non-malformed live singleton infants, born at term (≥37 weeks’ gestation) between 1999 and 2016, with Apgar scores of ≥7 at 1, 5, and 10 minutes.

Exposures

Infants with Apgar scores of 7, 8, and 9 at 1, 5, and 10 minutes were compared with those with an Apgar score of 10 at 1, 5, and 10 minutes, respectively.

Main outcome measures

Neonatal mortality and morbidity, including neonatal infections, asphyxia related complications, respiratory distress, and neonatal hypoglycaemia. Adjusted odds ratios (aOR), adjusted rate differences (aRD), and 95% confidence intervals were estimated.

Results

Compared with infants with an Apgar score of 10, aORs for neonatal mortality, neonatal infections, asphyxia related complications, respiratory distress, and neonatal hypoglycaemia were higher among infants with lower Apgar scores, especially at 5 and 10 minutes. For example, the aORs for respiratory distress for an Apgar score of 9 versus 10 were 2.0 (95% confidence interval 1.9 to 2.1) at 1 minute, 5.2 (5.1 to 5.4) at 5 minutes, and 12.4 (12.0 to 12.9) at 10 minutes. Compared with an Apgar score of 10 at 10 minutes, the aRD for respiratory distress was 9.5% (95% confidence interval 9.2% to 9.9%) for an Apgar score of 9 at 10 minutes, and 41.9% (37.7% to 46.4%) for an Apgar score of 7 at 10 minutes. A reduction in Apgar score from 10 at 5 minutes to 9 at 10 minutes was also associated with higher odds of neonatal morbidity, compared with a stable Apgar score of 10 at 5 and 10 minutes.

Conclusions

In term non-malformed infants with Apgar scores within the normal range (7 to 10), risks of neonatal mortality and morbidity are higher among infants with lower Apgar score values, and also among those experiencing a reduction in score from 5 minutes to 10 minutes (compared with infants with stable Apgar scores of 10).
Phase 0–1 early palliative home care cancer treatment intervention study
Authors: Dhollander Naomi , Smets Tinne , De Vleminck Aline , Van Belle Simon , Deliens Luc , Pardon Koen
Published: May 2019

Objectives

Recent studies have shown that the early provision of palliative care (PC) integrated into oncology in the hospital has beneficial effects on the quality of life of people who are dying and their family caregivers. However, a model to integrate palliative home care (PHC) early in oncology care is lacking. Therefore, our aim is to develop the Early Palliative Home care Embedded in Cancer Treatment (EPHECT) intervention.

Methods

We conducted a phase 0–1 study according to the Medical Research Council framework. Phase 0 consisted of a literature search on existing models for early integrated PC, and focus groups with PHC teams to investigate experiences with being introduced earlier. In phase 1, we developed a complex intervention to support the early integration of PHC in oncology care, based on the results of phase 0. The intervention components were reviewed and refined by professional caregivers and stakeholders.

Results

Phase 0 resulted in components underpinning existing interventions. Based on this information, we developed an intervention in phase 1 consisting of: (1) information sessions for involved professionals, (2) general practitioner as coordinator of care, (3) regular and tailored home consultations by the PHC team, (4) a semistructured conversation guide to facilitate consultations, and (5) interprofessional and transmural collaboration.

Conclusion

Taking into account the experiences of the PHC teams with being involved earlier and the components underpinning successful interventions, the EPHECT intervention for the home setting was developed. The feasibility and acceptability of the intervention will be tested in a phase II study.
Link speed estimation using GPS data: an empirical investigation of some issues
Authors: El Esawey Mohamed , Nasr Khaled
Published: May 2019

Probe vehicles equipped with tracking devices such as global positioning system receivers (GPS) can be utilized for real-time link speed estimation. In this empirical research, the impact of the data collection resolution, also known as the polling interval, on the network coverage and link speed estimation accuracy was explored. Furthermore, a comparison was made between different methods that currently exist for average link speed estimation using GPS data. The study made use of a 1 s resolution GPS dataset that covered 100 trips in Vancouver, BC. The dataset was sub-sampled 36 times to simulate cases of 5–180 s sampling intervals. An existing map-matching algorithm was used to match the GPS points to the correct travel links for the 36 datasets. Consequently, average link speed was calculated for each link in the dataset using the time stamp difference method and the average instantaneous speed method. A slight variation of the average instantaneous speed method was also tested where instantaneous speeds were computed from position information only. An improvement was further applied to the latter method by using a path inference technique to compensate for the lack of GPS points on some links. The speed estimation methods were compared at different polling intervals and the results were discussed. In general, it was shown that the average instantaneous speed method provides the highest estimation accuracy while the path inference method provides the highest coverage compared to all other methods.
New Constraint Qualifications for S-Stationarity for MPEC with Nonsmooth Objective
Authors: Zhang Peng , Zhang Jin , Lin Gui-Hua , Yang Xinmin
Published: May 2019

This paper considers a mathematical problem with equilibrium constraints (MPEC) in which the objective is locally Lipschitz continuous but not continuously differentiable everywhere. Our focus is on constraint qualifications for the nonsmooth S-stationarity in the sense of the limiting subdifferentials. First, although the MPEC-LICQ is not a constraint qualification for the nonsmooth S-stationarity, we show that the MPEC-LICQ can serve as a constraint qualification for the nonsmooth S-stationarity under some kind of regularity. Then, we extend some new constraint qualifications for nonlinear programs to the considered nonsmooth MPEC and show that all of them can serve as constraint qualifications for the nonsmooth S-stationarity. We further extend these results to the multiobjective case.
Preparation and properties of solid electrolyte CaxBi1.7−xW0.3O3.45−0.5x electrolyte material by sol–gel combution method
Authors: Yang Jie , Tian Changan , Wang Yu , Meng Junjie , Ji Dongdong , Chen Jihai , Yin Qiyi , Zhang Xia , Sun Qinying , Xiao Sa
Published: May 2019

CaxBi[Formula: see text]W[Formula: see text]O[Formula: see text] (CBW) ([Formula: see text], 0.05, 0.10, 0.15, 0.20, 0.30) electrolyte material were synthesized by sol–gel self-combustion method. The samples were characterized by thermogravimetric-differential thermogravimetric analysis(TG-DSC), X-ray diffraction, scanning electron microscopy (SEM), porosity and electrochemical impedance spectroscopy (EIS). The results show the powders CaxBi[Formula: see text]W[Formula: see text]O[Formula: see text] (CBW) with fluorite crystal structure can be obtained after the precursor was calcined at 760∘C. When sintered at 780∘C for 2[Formula: see text]h, the compact ceramic sintered with relative density higher than 97% can be obtained. The electrochemical studies showed that CaxBi[Formula: see text]W[Formula: see text]O[Formula: see text] (CBW) have high ionic conductivity after 780∘C sintering. The sample Ca[Formula: see text]Bi[Formula: see text]W[Formula: see text]O[Formula: see text] exhibits a conductivity of 0.07978 S[Formula: see text][Formula: see text][Formula: see text]cm[Formula: see text] at 750∘C, and the activation energy is 0.845[Formula: see text]eV, which is expected to be applied to the electrolyte materials for intermediate temperature solid oxide fuel cells (SOFC).
A Dynamic Data-throttling Approach to Minimize Workflow Imbalance
Authors: Rodríguez Ricardo J. , Tolosana-calasanz Rafael , Rana Omer F.
Published: May 2019

Scientific workflows enable scientists to undertake analysis on large datasets and perform complex scientific simulations. These workflows are often mapped onto distributed and parallel computational infrastructures to speed up their executions. Prior to its execution, a workflow structure may suffer transformations to accommodate the computing infrastructures, normally involving task clustering and partitioning. However, these transformations may cause workflow imbalance because of the difference between execution task times (runtime imbalance) or because of unconsidered data dependencies that lead to data locality issues (data imbalance). In this article, to mitigate these imbalances, we enhance the workflow lifecycle process in use by introducing a workflow imbalance phase that quantifies workflow imbalance after the transformations. Our technique is based on structural analysis of Petri nets, obtained by model transformation of a data-intensive workflow, and Linear Programming techniques. Our analysis can be used to assist workflow practitioners in finding more efficient ways of transforming and scheduling their workflows. Moreover, based on our analysis, we also propose a technique to mitigate workflow imbalance by data throttling. Our approach is based on autonomic computing principles that determine how data transmission must be throttled throughout workflow jobs. Our autonomic data-throttling approach mainly monitors the execution of the workflow and recompute data-throttling values when certain watchpoints are reached and time derivation is observed. We validate our approach by a formal proof and by simulations along with the Montage workflow. Our findings show that a dynamic data-throttling approach is feasible, does not introduce a significant overhead, and minimizes the usage of input buffers and network bandwidth.
Discovering Patterns for Fact Checking in Knowledge Graphs
Authors: Lin Peng , Song Qi , Wu Yinghui , Pi Jiaxing
Published: May 2019

This article presents a new framework that incorporates graph patterns to support fact checking in knowledge graphs. Our method discovers discriminant graph patterns to construct classifiers for fact prediction. First, we propose a class of
graph fact checking rules
(GFCs). A GFC incorporates graph patterns that best distinguish true and false facts of generalized fact statements. We provide statistical measures to characterize useful patterns that are both discriminant and diversified. Second, we show that it is feasible to discover GFCs in large graphs with optimality guarantees. We develop an algorithm that performs localized search to generate a stream of graph patterns, and dynamically assemble the best GFCs from multiple GFC sets, where each set ensures quality scores within certain ranges. The algorithm guarantees a (1/2−ϵ) approximation when it (early) terminates. We also develop a space-efficient alternative that dynamically spawns prioritized patterns with best marginal gains to the verified GFCs. It guarantees a (1−1/
e
) approximation. Both strategies guarantee a bounded time cost independent of the size of the underlying graph. Third, to support fact checking, we develop two classifiers, which make use of top-ranked GFCs as predictive rules or instance-level features of the pattern matches induced by GFCs, respectively. Using real-world data, we experimentally verify the efficiency and the effectiveness of GFC-based techniques for fact checking in knowledge graphs and verify its application in knowledge exploration and news prediction.
Handwritten Manipuri Meetei-Mayek Classification Using Convolutional Neural Network
Authors: Nongmeikapam Kishorjit , Wahengbam Kanan , Meetei Oinam Nickson , Tuithung Themrichon
Published: May 2019

A new technique for classifying all 56 different characters of the Manipuri Meetei-Mayek (MMM) is proposed herein. The characters are grouped under five categories, which are Eeyek Eepee (original alphabets), Lom Eeyek (additional letters), Cheising Eeyek (digits), Lonsum Eeyek (letters with short endings), and Cheitap Eeyek (vowel signs. Two related works proposed by previous researchers are studied for understanding the benefits claimed by the proposed deep learning approach in handwritten Manipuri Meetei-Mayek. (1) Histogram of Oriented (HOG) with SVM classifier is implemented for thoroughly understanding how HOG features can influence accuracy. (2) The handwritten samples are trained using simple Convolutional Neural Network (CNN) and compared with the proposed CNN-based architecture. Significant progress has been made in the field of Optical Character Recognition (OCR) for well-known Indian languages as well as globally popular languages. Our work is novel in the sense that there is no record of work available to date that is able to classify all 56 classes of the MMM. It will also serve as a pre-cursor for developing end-to-end OCR software for translating old manuscripts, newspaper archives, books, and so on.
A Survey on Modality Characteristics, Performance Evaluation Metrics, and Security for Traditional and Wearable Biometric Systems
Authors: Sundararajan Aditya , Sarwat Arif I. , Pons Alexander
Published: May 2019

Biometric research is directed increasingly toward Wearable Biometric Systems (WBS) for user authentication and identification. However, prior to engaging in WBS research, how their operational dynamics and design considerations differ from those of Traditional Biometric Systems (TBS) must be understood. While the current literature is cognizant of those differences, there is no effective work that summarizes the factors where TBS and WBS differ, namely, their modality characteristics, performance, security, and privacy. To bridge the gap, this article accordingly reviews and compares the key characteristics of modalities, contrasts the metrics used to evaluate system performance, and highlights the divergence in critical vulnerabilities, attacks, and defenses for TBS and WBS. It further discusses how these factors affect the design considerations for WBS, the open challenges, and future directions of research in these areas. In doing so, the article provides a big-picture overview of the important avenues of challenges and potential solutions that researchers entering the field should be aware of. Hence, this survey aims to be a starting point for researchers in comprehending the fundamental differences between TBS and WBS before understanding the core challenges associated with WBS and its design.
SIGecom job market candidate profiles 2019
Authors: Gkatzelis Vasilis , Hartline Jason
Published: May 2019

This is the fourth annual collection of profiles of the junior faculty job market candidates of the SIGecom community. The twenty five candidates for 2019 are listed alphabetically and indexed by research areas that define the interests of the community. The candidates can be contacted individually or via the moderated mailing list ecom-candidates2019@acm.org.
Strategyproof linear regression in high dimensions
Authors: Chen Yiling , Podimata Chara , Procaccia Ariel D. , Shah Nisarg
Published: May 2019

In this letter, we outline some of the results from our recent work, which is part of an emerging line of research at the intersection of machine learning and mechanism design aiming to avoid noise in training data by correctly aligning the incentives of data sources. Specifically, we focus on the ubiquitous problem of
linear regression,
where
strategyproof
mechanisms have previously been identified in two dimensions. In our setting, agents have single-peaked preferences and can manipulate only their response variables. Our main contribution is the discovery of a family of
group strategyproof
linear regression mechanisms in any number of dimensions, which we call
generalized resistant hyperplane
mechanisms. The game-theoretic properties of these mechanisms --- and, in fact, their very existence --- are established through a connection to a discrete version of the Ham Sandwich Theorem.
An improved welfare guarantee for first-price auctions
Authors: Hoy Darrell , Taggart Sam , Wang Zihe
Published: May 2019

We highlight recent progress in worst-case analysis of welfare in first price auctions. It was shown in [Syrgkanis and Tardos 2013] that in any Bayes-Nash equilibrium of a first-price auction, the expected social welfare is at least a (1 - 1/e) ≈ .63-fraction of optimal. This result uses
smoothness,
the standard technique for worst-case welfare analysis of games, and is tight if bidders' value distributions are permitted to be correlated. With independent distributions, however, the worst-known example, due to [Hartline et al. 2014], exhibits welfare that is a ≈ .89-fraction of optimal. This gap has persisted in spite of the canonical nature of the first-price auction and the prevalence of the independence assumption. In [Hoy et al. 2018], we improve the worst-case lower bound on first-price auction welfare assuming independently distributed values from (1 - 1/e) to ≈ .743. Notably, the proof of this result eschews smoothness in favor of techniques which exploit independence. This note overviews the new approach, and discusses research directions opened up by the result.
The Utility of Event-Related Potentials in Clinical Psychology
Authors: Hajcak Greg , Klawohn Julia , Meyer Alexandria
Published: May 2019

Event-related potentials (ERPs) are direct measures of brain activity that can be leveraged for clinically meaningful research. They can relate robustly both to continuous measures of individual difference and to categorical diagnoses in ways that clarify similarities and distinctions between apparently related disorders and traits. ERPs can be linked to genetic risk, can act as moderators of developmental trajectories and responses to stress, and can be leveraged to identify those at greater risk for psychopathology, especially when used in combination with other neural and self-report measures. ERPs can inform models of the development of, and risk for, psychopathology. Finally, ERPs can be used as targets for existing and novel interventions and prevention efforts. We provide concrete examples for each of these possibilities by focusing on programmatic research on the error-related negativity and anxiety, and thus show that ERPs are poised to make greater contributions toward the identification, prediction, treatment, and prevention of mental disorders.
Glutamine synthetase in avian muscle contributes to a positive myogenic response to ammonia compared with mammalian muscle
Authors: Stern Rachel Allysa , Mozdziak Paul E.
Published: May 2019

In mammalian models of cirrhosis, plasma ammonia concentration increases, having numerous adverse effects, including sarcopenia. The objective of this study was to identify differences between avian and mammalian myogenic response to applied ammonia and glutamine. Primary chicken breast and thigh, primary rat, and C2C12myotubes were treated with ammonium acetate (AA, 10 mM) or glutamine (10 mM) for 24 h and compared with sodium acetate (10 mM) and untreated controls. Myostatin mRNA was significantly higher in C2C12and rat myotubes treated with AA compared with glutamine and controls ( P < 0.01), whereas myostatin was unchanged in chicken myotubes. AA-treated C2C12myotubes had significantly higher glutamine synthetase (GS) mRNA expression compared with controls, but GS protein expression was unchanged. In contrast, GS mRNA expression was unchanged in thigh myotubes, but GS protein expression was significantly higher in AA-treated thigh myotubes ( P < 0.05). In both breast and thigh myotubes, intracellular glutamine concentration was significantly increased in AA- and glutamine-treated myotubes compared with controls but was only increased in glutamine-treated C2C12and rat myotubes ( P < 0.05). Glutamine concentration was significantly higher in all treatment media collected from avian myotube cultures compared with both C2C12and rat media ( P < 0.01). Myotube diameter was significantly larger in avian myotubes after treatment with both AA and glutamine ( P < 0.05). C2C12and rat myotubes had a significantly smaller myotube diameter after AA treatment ( P < 0.001). Altogether, these data support species differences in skeletal muscle ammonia metabolism and suggest that glutamine synthesis is a mechanism of ammonia utilization in avian muscle.
Strain-dependent effects on lung structure, matrix remodeling, and Stat3/Smad2 signaling in C57BL/6N and C57BL/6J mice after neonatal hyperoxia
Authors: Will Johannes P. , Hirani Dharmesh , Thielen Florian , Klein Fabian , Vohlen Christina , Dinger Katharina , Dötsch Jörg , Alejandre Alcázar Miguel A.
Published: May 2019

Bronchopulmonary dysplasia (BPD) is a chronic lung disease of preterm infants, characterized by lung growth arrest and matrix remodeling. Various animal models provide mechanistic insights in the pathogenesis of BPD. Since there is increasing evidence that genetic susceptibility modifies the response to lung injury, we investigated strain-dependent effects in hyperoxia (HYX)-induced lung injury of newborn mice. To this end, we exposed newborn C57BL/6N and C57BL/6J mice to 85% O2 (HYX) or normoxia (NOX; 21% O2) for 28 days, followed by lung excision for histological and molecular measurements. BL/6J-NOX mice exhibited a lower body and lung weight than BL/6N-NOX mice; hyperoxia reduced body weight in both strains and increased lung weight only in BL/6J-HYX mice. Quantitative histomorphometric analyses revealed reduced alveolar formation in lungs of both strains after HYX, but the effect was greater in BL/6J-HYX mice than BL/6N-HYX mice. Septal thickness was lower in BL/6J-NOX mice than BL/6N-NOX mice but increased in both strains after HYX. Elastic fiber density was significantly greater in BL/6J-HYX mice than BL/6N-HYX mice. Lungs of BL/6J-HYX mice were protected from changes in gene expression of fibrillin-1, fibrillin-2, fibulin-4, fibulin-5, and surfactant proteins seen in BL/6N-HYX mice. Finally, Stat3 was activated by HYX in both strains; in contrast, activation of Smad2 was markedly greater in lungs of BL/6N mice than BL/6J mice after HYX. In summary, we demonstrate strain-dependent differences in lung structure and matrix, alveolar epithelial cell markers, and Smad2 (transforming growth factor β) signaling in neonatal HYX-induced lung injury. Strain-dependent effects and genetic susceptibility need be taken into consideration for reproducibility and reliability of results in animal models.
Age-Dependent Oxidative Stress Elevates Arginase 1 and Uncoupled Nitric Oxide Synthesis in Skeletal Muscle of Aged Mice
Authors: Pandya Chirayu D. , Lee Byung , Toque Haroldo A. , Mendhe Bharati , Bragg Robert T. , Pandya Bhaumik , Atawia Reem T. , Isales Carlos , Hamrick Mark , Caldwell R. William , Fulzele Sadanand
Published: May 2019

Aging is associated with reduced muscle mass (sarcopenia) and poor bone quality (osteoporosis), which together increase the incidence of falls and bone fractures. It is widely appreciated that aging triggers systemic oxidative stress, which can impair myoblast cell survival and differentiation. We previously reported that arginase plays an important role in oxidative stress-dependent bone loss. We hypothesized that arginase activity is dysregulated with aging in muscles and may be involved in muscle pathophysiology. To investigate this, we analyzed arginase activity and its expression in skeletal muscles of young and aged mice. We found that arginase activity and arginase 1 expression were significantly elevated in aged muscles. We also demonstrated that SOD2, GPx1, and NOX2 increased with age in skeletal muscle. Most importantly, we also demonstrated elevated levels of peroxynitrite formation and uncoupling of eNOS in aged muscles. Our in vitro studies using C2C12 myoblasts showed that the oxidative stress treatment increased arginase activity, decreased cell survival, and increased apoptotic markers. These effects were reversed by treatment with an arginase inhibitor, 2(S)-amino-6-boronohexanoic acid (ABH). Our study provides strong evidence that L-arginine metabolism is altered in aged muscle and that arginase inhibition could be used as a novel therapeutic target for age-related muscle complications.
Electromagnetic Characteristics Measurement Setup at Variable Temperatures Using a Coaxial Cell
Authors: Letertre Thibaut , Pouliguen Philippe , Sabouroux Pierre
Published: May 2019

This article presents an easy way to measure frequency dependence of the complex permittivity and complex permeability for any kind of material from 10 MHz to 6 GHz, with temperature variation between the ambient temperature and 85°C. This work is based on a well-known transmission/reflection technique using a coaxial line equipped with a thermoregulation system to manage temperature variations in the sample confinement area. The paper underlines some effects which have to be taken into account with temperature variation. APU10 and cyclohexanol are presented as examples of solid and liquid reference materials.
The Role of the Microbiota in the Diabetic Peripheral Artery Disease
Authors: Biscetti Federico , Nardella Elisabetta , Cecchini Andrea Leonardo , Landolfi Raffaele , Flex Andrea
Published: May 2019

Vascular complications of diabetes mellitus represent a major public health problem. Although many steps forward have been made to define the causes and to find the best possible therapies, the problem remains crucial. In recent years, more and more evidences have defined a link between microbiota and the initiation, promotion, and evolution of atherosclerotic disease, even in the diabetic scenario. There is an urgency to develop the knowledge of modern medicine about the link between gut microbiota and its host’s metabolic pathways, and it would be useful to understand and justify the interindividual diversity of clinical disease presentation of diabetic vascular complication even if an optimization of pharmacological treatment has been made or in the case of young patients where hypertension, dyslipidemia, and diabetes are not able to justify a very quick progress of atherosclerotic process. The aim of the present review is to gather all the best available evidence in this regard and to define a new role of the microbiota in this field, from biomarker to possible therapeutic target.
Current Cigarette Smoking and Its Predictors among School-Going Adolescents in East Africa: A Systematic Review and Meta-Analysis
Authors: Tezera Nega , Endalamaw Aklilu
Published: May 2019

Background. In developing countries, tobacco smoking has its own contribution to the burden of noncommunicable causes of morbidity and mortality. Studies estimated the burden of cigarette smoking among school-going adolescents in different geographical areas of East Africa. However, due to discrepancies found among those different findings, there is no representative data about the burden of smoking in the continent. Objectives. This systematic review and meta-analysis aimed to assess the pooled prevalence of current cigarette smoking and its associated factors among school-going adolescents in East Africa. Methods. PubMed, Google Scholar, and the Web of Science Library were searched to access included articles. A weighted inverse-variance random-effects model was used to estimate the prevalence of current cigarette smoking. Variations in the pooled estimates of the prevalence were adjusted through subgroup analysis according to the specific country, where the study was conducted. Funnel plot and Egger’s regression test were used to check publication bias. STATA version 14 statistical software was used for meta-analysis. Results. A total of 26,875 school-going adolescents were included. The pooled prevalence of current cigarette smoking among school-going adolescents in East Africa was found to be 9.02% (95%CI: 6.34-11.70). Based on the subgroup analysis, current cigarette smoking among school-going adolescents was estimated at 9.8% in Kenya, 7.72% in Ethiopia, 10.83% in Uganda, 13.6% in Sudan, and 4% in Tanzania. Conclusions. This meta-analysis revealed that the prevalence of current cigarette smoking is increasing among school-going adolescents in East Africa. Therefore, countries have to realize sale prevention policies, establishing and/or strengthening antismoking campaigners designed for school-going adolescents, and providing training for teachers to be antismoking campaigners.