bluuebunny/crossref_metadata_2025 huggingface dataset:
The Histone Deacetylase Inhibitor I13 Induces Differentiation of M2, M3 and M5 Subtypes of Acute Myeloid Leukemia Cells and Leukemic Stem-Like Cells
Authors: Ma Xiangyu , Zhao Mengjie , Wu Zhuo-Xun , Yao Jingfang , Zhang Lei , Wang Jinhong , Hu Zhenbo , Wei Liuya , Chen Zhe-Sheng
Published: April 2022

Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy characterized by reduced differentiation of myeloid cells and uncontrolled cell proliferation. AML is prone to drug resistance and has a high recurrence rate during treatment with cytarabine-based chemotherapy. Our study aims to explore the cell differentiation effect of a potent histone deacetylase inhibitor (HDACi), I13, and its possible mechanism on AML cell lines (Kasumi-1, KG-1, MOLM-13 and NB4). It has been shown that I13 can significantly inhibit proliferation and colony formation of these AML cells by inducing cell differentiation coupled with cell-cycle exit at G0/G1. Mechanically, I13 presented the property of HDAC inhibition, as assessed by the acetylation of histone H3, which led to the differentiation of Kasumi-1 cells. In addition, the HDAC inhibition of I13 likely dictated the activation of the antigen processing and presentation pathway, which maybe has the potential to promote immune cells to recognize leukemic cells and respond directly against leukemic cells. These results indicated that I13 could induce differentiation of M3 and M5 subtypes of AML cells, M2 subtype AML cells with t(8;21) translocation and leukemic stem-like cells. Therefore, I13 could be an alternative compound which is able to overcome differentiation blocks in AML.
Clonal Hematopoiesis at the Crossroads of Inflammatory Bowel Diseases and Hematological Malignancies: A Biological Link?
Authors: Cumbo Cosimo , Tarantini Francesco , Zagaria Antonella , Anelli Luisa , Minervini Crescenzio Francesco , Coccaro Nicoletta , Tota Giuseppina , Impera Luciana , Parciante Elisa , Conserva Maria Rosa , Redavid Immacolata , Carluccio Paola , Delia Mario , Giordano Annamaria , Longo Maria Chiara , Perrone Tommasina , Rossi Antonella Russo , Specchia Giorgina , Musto Pellegrino , Albano Francesco
Published: April 2022

Inflammatory bowel diseases (IBDs) are a group of chronic conditions of the gastrointestinal tract in which nationwide studies have revealed a higher risk of hematological malignancies (HMs). Clonal hematopoiesis (CH) is a premalignant condition defined by the presence of an acquired somatic mutation characterized by a variant allele frequency (VAF) of ≥2%, in a gene frequently associated with HMs. A growing body of evidence suggests a correlation between inflammation and CH; its occurrence in the context of IBD has been previously demonstrated. With the aim to assess CH possible co-occurrence in patients with an IBD associated with HMs, we performed a targeted next-generation sequencing analysis in a cohort of thirteen patients who were referred to our center with IBD associated with HMs. Eleven (85%) patients showed one or more mutations in CH-associated genes; DNMT3A was the most frequently mutated gene, followed by ASXL1 and JAK2. These results may suggest that the mechanisms at the basis of the inflammatory environment could potentially select for the growth of hematopoietic clones harboring specific mutations. In this context, CH emergence may be boosted by the proinflammatory IBD environment, thus acting as a biological link between IBD and the HM onset. If these data are confirmed, IBD patients screened and positive for CH should undergo a hematologic follow-up to assess the risk of developing HM. Future study will clarify the relationship between these conditions.
Safety of Therapeutic Apheresis in Children and Adolescents
Authors: Taylan Christina , Schaaf Anne , Dorn Corina , Schmitt Claus Peter , Loos Sebastian , Kanzelmeyer Nele , Pape Lars , Müller Dominik , Weber Lutz T. , Thumfart Julia
Published: April 2022

Background

Therapeutic apheresis (TA) is based on the principles of either removing dissolved pathogenic substances (e.g., antibodies) from the blood plasma or replacing plasma factors. It expands the therapeutic scope for a variety of diseases. Safety analysis in the pediatric field are scant. The aim of this analysis was to analyze specific complications of TA modalities – plasma exchange (PE) and immunoadsorption (IA) – in children and adolescents.

Methods

Children and adolescents (n = 298) who had received TA from 2008 to 2018 in five pediatric nephrology centers were analyzed retrospectively. In total, 4.004 treatments (2.287 PE and 1.717 IA) were evaluated.

Results

Indications for TA were mainly nephrological and neurological diseases. The three main indications were antibody-mediated graft rejection (13.4%), hemolytic uremic syndrome mainly with neurological involvement (12.8%), and AB0-incompatible transplantation (11.7%). Complications developed in 440 of the 4004 sessions (11%), of which one third were non-specific (nausea, headache). IA was better tolerated than PE. Complications were reported in 9.5% (n = 163) of the IA versus 12.1% (277) of the PE sessions (p < 0.001). When considering different types of complications, significantly more non-specific/non-allergic events (p = 0.02) and allergic reactions occurred in PE sessions (p < 0.001). More complications occurred with PE, when using fresh frozen plasma (16.2%; n = 145) in comparison to human albumin (14.5%; n = 115) (p < 0.001).

Conclusions

Therapeutic apheresis in childhood and adolescence is a safe treatment procedure. IA showed a lower complication rate than PE. Therefore, IA may be preferably provided if the underlying disease pathomechanisms do not require PE.
Positional Context of Myonuclear Transcription During Injury-Induced Muscle Regeneration
Authors: Buckley Kole H. , Nestor-Kalinoski Andrea L. , Pizza Francis X.
Published: April 2022

Fundamental aspects underlying downstream processes of skeletal muscle regeneration, such as myonuclear positioning and transcription are poorly understood. This investigation begins to address deficiencies in knowledge by examining the kinetics of myonuclear accretion, positioning, and global transcription during injury-induced muscle regeneration in mice. We demonstrate that myonuclear accretion plateaus within 7 days of an injury and that the majority (∼70%) of myonuclei are centrally aligned in linear arrays (nuclear chains) throughout the course of regeneration. Relatively few myonuclei were found in a peripheral position (∼20%) or clustered (∼10%) together during regeneration. Importantly, transcriptional activity of individual myonuclei in nuclear chains was high, and greater than that of peripheral or clustered myonuclei. Transcription occurring primarily in nuclear chains elevated the collective transcriptional activity of regenerating myofibers during the later stage of regeneration. Importantly, the number of myonuclei in chains and their transcriptional activity were statistically correlated with an increase in myofiber size during regeneration. Our findings demonstrate the positional context of transcription during regeneration and highlight the importance of centralized nuclear chains in facilitating hypertrophy of regenerating myofibers after injury.
The Relationship Between Mindful Agency and Self-Leadership of Chinese Private College Undergraduates: Mediating Effect of Metacognitive Ability
Authors: Chen Zhaojun , Zhang Xingxia
Published: April 2022

As one of 21st century key skills, self-leadership is not only the internal factor of private college undergraduates’ independent development, but also related to the quality improvement of talent cultivation of private undergraduate colleges. It is proved that mindfulness or metacognition separately has the predictive effect on self-leadership, but their structural relationships has not been revealed. The present study explored the interrelations between mindful agency, metacognitive ability, and self-leadership through the mediation analysis with structural equation modeling, and bootstrapping was conducted to test the mediating effect. The sample comprised 1,244 private undergraduate sophomore (38.4% male and 61.6% female), and they completed online questionnaires of mindful agency, metacognitive ability, and self-leadership. The results revealed that mindful agency of private undergraduate students not only directly and positively predicted self-leadership, but also indirectly and positively predicted self-leadership through the mediating effect of metacognitive ability. Metacognitive ability partially mediated the relationship between mindful agency and self-leadership. The direct effect of mindful agency and the mediating effect of metacognitive ability, respectively, account for 86.9% and 13.1% of the total effect. The results suggest that the more mindful private college undergraduates are, the more willing they are to practise their metacognitive skills in their learning, and the more progress in self-leadership they make. Educational implications for mindfulness training and metacognition practice to foster their self-leadership are discussed.
The Presence of a Visual Dividing Line Increases Consumer Memory Through Attention Grabbing
Authors: Ouyang Jun , Jia Yanli
Published: April 2022

Marketers often use a visual line to divide the product information on an advertisement into left-right (or top-bottom) segments for aesthetic or categorization purposes. The present research examined the effect of the dividing line on the consumer memory. Across three studies (including an eye-tracking study and a field one), we showed that the presence of a dividing line enhances consumers’ memory about the products displayed on the left/top of an advertisement. This effect occurs because the dividing line orients participants’ first eye fixation to the left/top area of the advertisement, such that their visual attention is largely restricted to that area and they could better remember the contents displayed on that area. The theoretical contributions and implications for marketers and consumers are discussed.
The Impact of COVID-19 Pandemic on Individuals With Pre-existing Obsessive-Compulsive Disorder in the State of Qatar: An Exploratory Cross-Sectional Study
Authors: Siddiqui Maryam , Wadoo Ovais , Currie James , Alabdulla Majid , Al Siaghy Areej , AlSiddiqi Abdulkarim , Khalaf Eslam , Chandra Prem , Reagu Shuja
Published: April 2022

Background

Published evidence about the impact of the COVID-19 pandemic on Obsessive-Compulsive Disorder (OCD) is conflicting. Most studies suggest an increase in the severity of OCD in people with pre-existing OCD, whereas some do not.

Aim

Given the conflicting evidence globally and lack of data from the Arab world, we aimed to explore the impact of the pandemic on obsessive-compulsive symptoms in adults with pre-existing OCD.

Methods

A telephonic questionnaire-based cross-sectional study among adults with pre-existing OCD and specifically with fear of contamination and washing compulsions being major symptom dimensions of OCD. The severity of OCD during the pandemic was compared with their pre-pandemic scores. The severity of OCD was assessed using the Yale-Brown Obsessive-Compulsive Scale (YBOCS).

Results

Those with the duration of diagnosis of OCD of<10 years showed a statistically significant increase in the mean YBOCS score of 5.54 from pre-pandemic to during pandemic, which was significant at p = 0.006. This significance was maintained across the Compulsive and Obsessive subsets of the scale.

Conclusion

Adults with pre-existing OCD with fear of contamination reported a statistically significant increase in severity of obsessive-compulsive symptoms only if the duration of their OCD diagnosis was relatively shorter (<10 years). In the context of the conflicting evidence regarding the worsening of OCD symptoms due to the unique infection control measures of this pandemic, this study highlights the importance of the impact of the duration of the disorder and the subtype of the disorder. Such classification might help public health resources to be directed better at those most at risk and also help us understand the very nature of this disorder better.
It Takes Two to Tango: How the COVID-19 Vaccination Campaign in Israel Was Framed by the Health Ministry vs. the Television News
Authors: Gesser-Edelsburg Anat , Hijazi Rana , Cohen Ricky
Published: April 2022

Background

The internet has become a major resource in information transfer during COVID-19, and traditional means of communication are digitized and accessible online to the public at large.

Objectives

This study seeks to examine how Israel's two main television news channels (Channel 12 and Channel 13) covered the Covid-19 vaccination campaign, compared to how the Ministry of Health ran the campaign.

Methods

A qualitative study based on triangulation of online content analyses from three different sources: advertising campaigns, social media posts and reports on television news channels. The research sample included 252 reports from the newsrooms of Channel 13 (n = 151) and Channel N12 (n = 101), Israel's two leading news channels, all broadcast between December 1, 2020 and November 30, 2021. The sample also included posts from Israel Ministry of Health Facebook page and advertising campaigns from the Facebook page of the Israel Government Advertising Agency (LAPAM), which constructs advertising campaigns for the MOH (113 items).

Results

The research findings reveal congruence between the way the MOH framed its vaccination campaign and news coverage of the vaccination issue. The vaccination campaign used three primary framing strategies: (1) positive framing (emphasizing the vaccine's advantages and stressing that the vaccine is safe and effective based on cost-benefit calculations and public health perspectives); (2) fear appeal strategy (conveying persuasive messages that seek to arouse fear through threats of impending danger or harm); (3) attribution of responsibility strategy (blaming the unvaccinated and targeting all those who criticized Israel's generic vaccination policy).

Conclusion

As the watchdog of democracy, the news should function as a professional and objective source that criticizes government systems if necessary and strives to uncover the truth throughout the crisis. Public trust, which is so essential during such a crisis, can be achieved only if the news channels provide reports and meaningful journalistic investigations that challenge the system. By doing so, they can help fight conflicts of interest that divert management of the crisis from the professional health field to the political-economic arena.
Aligning Physical Literacy With Critical Positive Youth Development and Student-Centered Pedagogy: Implications for Today's Youth
Authors: Santos Fernando , Newman Tarkington J. , Aytur Semra , Farias Claudio
Published: April 2022

The purpose of this article is three-fold: (1) revisit the concept of life skills to position physical literacy as a social justice life skill; (2) make the argument that physical literacy is particularly relevant within a critical positive youth development perspective; and (3) propose a novel critical praxis for developing physical literacy amongst youth. When considering emergent social issues, youth programming has the potential to integrate concepts from a range of theoretical frameworks, which may help youth transform into social change activists and competent movers. Such critical perspectives may guide sport and physical education programming as contemporary society poses numerous challenges concerning youths' diverse emotional, mental, physical, and social needs. In order to advance knowledge and practice, we urge researchers and practitioners to rethink the way sport and physical education has been traditionally conceptualized. Ultimately, we propose that educating individuals to recognize and then confront neoliberal values within a post-pandemic landscape is critical. These notions may help researchers (re)frame their positionality and readiness to tackle physical literacy through broader theoretical lenses which—as alluded to in this article—may equip practitioners and researchers to meaningfully advance social justice.
Measuring and Mapping Food Security Status of Rajasthan, India: A District-Level Analysis
Authors: Jatav Surendra Singh , Nayak Sanatan , Singh Naveen Prakash , Naik Kalu
Published: April 2022

The present study tries to analyse the status of food security, along with its various components, such as food availability, accessibility, and stability with the help of a multidimensional index across districts of Rajasthan, India based on an indicator approach. The QGIS mapping computer application and quintile method were used to map districts into low, medium, high, and very high categories. Furthermore, multiple regression analysis was applied to find out the significant determinants of food security and its respective components. The results confirm that there is a wide range of inequalities in terms of food security and its components of availability, accessibility, and stability across districts. It was found that the Ganganagar district (0.407) was rated the most food-secure district due to relatively higher food stability (0.401) in the Rajasthan state. On the contrary, lower food availability (0.084) and accessibility (0.183) contributed to the lowest food security in the Dungarpur district. Moreover, districts associated with dry regions are highly vulnerable and relatively less food secure compared to districts having surface irrigation facilities. Hence, the study recommends; diversification from farm to non-farm activities; sufficient storage capacity to control price fluctuations throughout the year, formulation and dissemination of climate-resilient technologies; investment in infrastructure, promotion of water management, conservation technologies, regulation and replenishment of groundwater in rural areas for augmenting cropping intensity; district-specific policies to arrest food insecurity; and strengthening the coverage of rural employment programme, i.e. MGNREGA.
Production of Meat and Milk from Grass in the United Kingdom
Authors: Barbour Robert , Young Richard H. , Wilkinson J. Michael
Published: April 2022

Grassland accounts for a high proportion of the agricultural area of the United Kingdom, but the significance of its contribution to the nation’s food supply has been questioned. Using representative figures for the composition of UK ruminant livestock diets, we estimated the total production of human-edible protein from grass and forage crops consumed by cattle and sheep. We found that this equates to 21.5 g of protein per person per day, of which 15.2 g comes from milk, 4.71 g from beef and 1.60 g from sheep meat. This represents 45% of the total amount of human-edible animal protein produced in the UK (46.6 g/head) and is equivalent to one-third of the recommended adult human daily protein intake of 64 g/head. Given the growing pressure to produce food in a more resource-efficient manner, grasslands have a valuable role to play in providing food alongside multiple public goods.
The Purinergic Landscape of Non-Small Cell Lung Cancer
Authors: Janho dit Hreich Serena , Benzaquen Jonathan , Hofman Paul , Vouret-Craviari Valérie
Published: April 2022

Lung cancer is the most common cancer worldwide. Despite recent therapeutic advances, including targeted therapies and immune checkpoint inhibitors, the disease progresses in almost all advanced lung cancers and in up to 50% of early-stage cancers. The purpose of this review is to discuss whether purinergic checkpoints (CD39, CD73, P2RX7, and ADORs), which shape the immune response in the tumor microenvironment, may represent novel therapeutic targets to combat progression of non-small cell lung cancer by enhancing the antitumor immune response.
Pain Relief after Stereotactic Radiotherapy of Pancreatic Adenocarcinoma: An Updated Systematic Review
Authors: Buwenge Milly , Arcelli Alessandra , Cellini Francesco , Deodato Francesco , Macchia Gabriella , Cilla Savino , Galietta Erika , Strigari Lidia , Malizia Claudio , Cammelli Silvia , Morganti Alessio G.
Published: April 2022

Severe pain is frequent in patients with locally advanced pancreatic ductal adenocarcinoma (PDCA). Stereotactic body radiotherapy (SBRT) provides high local control rates in these patients. The aim of this review was to systematically analyze the available evidence on pain relief in patients with PDCA. We updated our previous systematic review through a search on PubMed of papers published from 1 January 2018 to 30 June 2021. Studies with full available text, published in English, and reporting pain relief after SBRT on PDCA were included in this analysis. Statistical analysis was carried out using the MEDCALC statistical software. All tests were two-sided. The I2 statistic was used to quantify statistical heterogeneity (high heterogeneity level: >50%). Nineteen papers were included in this updated literature review. None of them specifically aimed at assessing pain and/or quality of life. The rate of analgesics reduction or suspension ranged between 40.0 and 100.0% (median: 60.3%) in six studies. The pooled rate was 71.5% (95% CI, 61.6–80.0%), with high heterogeneity between studies (Q2 test: p < 0.0001; I2 = 83.8%). The rate of complete response of pain after SBRT ranged between 30.0 and 81.3% (median: 48.4%) in three studies. The pooled rate was 51.9% (95% CI, 39.3–64.3%), with high heterogeneity (Q2 test: p < 0.008; I2 = 79.1%). The rate of partial plus complete pain response ranged between 44.4 and 100% (median: 78.6%) in nine studies. The pooled rate was 78.3% (95% CI, 71.0–84.5%), with high heterogeneity (Q2 test: p < 0.0001; I2 = 79.4%). A linear regression with sensitivity analysis showed significantly improved overall pain response as the EQD2α/β:10 increases (p: 0.005). Eight papers did not report any side effect during and after SBRT. In three studies only transient acute effects were recorded. The results of the included studies showed high heterogeneity. However, SBRT of PDCA resulted reasonably effective in producing pain relief in these patients. Further studies are needed to assess the impact of SBRT in this setting based on Patient-Reported Outcomes.
The Clinically Actionable Molecular Profile of Early versus Late-Stage Non-Small Cell Lung Cancer, an Individual Age and Sex Propensity-Matched Pair Analysis
Authors: McGuire Anna L. , McConechy Melissa K. , Melosky Barb L. , English John C. , Choi James J. , Peng Defen , Yee John , Furman Benjamin L. S. , Aguirre Hernandez Rosalia , Feijao Pedro , Mulder David , Hughesman Curtis , Yip Stephen
Published: April 2022

Background: Despite meticulous surgery for non-small cell lung cancer (NSCLC), relapse is as high as 70% at 5 years. Many institutions do not conduct reflexive molecular testing on early stage specimens, although targeted gene therapy may extend life by years in the event of recurrence. This ultimately delays definitive treatment with additional biopsy risking suboptimal tissue acquisition and quality for molecular testing. Objective: To compare molecular profiles of genetic alterations in early and late NSCLC to provide evidence that reflexive molecular testing provides clinically valuable information. Methods: A single-center propensity matched retrospective analysis was conducted using prospectively collected data. Adults with early and late-stage NSCLC had tissue subject to targeted panel-based NGS. Frequencies of putative drivers were compared, with 1:3 matching on the propensity score; p < 0.05 deemed statistically significant. Results: In total, 635 NSCLC patients underwent NGS (59 early, 576 late); 276 (43.5%) females; age 70.9 (±10.2) years; never smokers 140 (22.0%); 527 (83.0%) adenocarcinomas. Unadjusted frequencies of EGFR mutations were higher in the early cohort (30% vs. 18%). Following adjustment for sex and smoking status, similar frequencies for both early and late NSCLC were observed for variants in EGFR, KRAS, ALK, MET, and ROS1. Conclusion: The frequency of clinically actionable variants in early and late-stage NSCLC was found to be similar, providing evidence that molecular profiling should be performed on surgical specimens. This pre-determined profile is essential to avoid treatment delay for patients who will derive clinical benefit from targeted systemic therapy, in the high likelihood of subsequent relapse.
5-Fluorouracil/L-Leucovorin Plus Oxaliplatin (FOLFOX) Regimen as Salvage Chemotherapy for Patients with Unresectable Pancreatic Cancer Receiving Gemcitabine and Nab-Paclitaxel and 5-Fluorouracil/L-Leucovorin Plus Nanoliposomal Irinotecan: Preliminary Results from Clinical Practice
Authors: Yamai Takuo , Ikezawa Kenji , Kawamoto Yasuharu , Hirao Takeru , Higashi Sena , Daiku Kazuma , Maeda Shingo , Abe Yutaro , Urabe Makiko , Kai Yugo , Takada Ryoji , Nakabori Tasuku , Uehara Hiroyuki , Ohkawa Kazuyoshi
Published: April 2022

Salvage chemotherapy for patients with unresectable pancreatic cancer (UR-PC) who have been treated with gemcitabine and nab-paclitaxel (GnP), and 5-fluorouracil (5-FU)/l-leucovorin (LV) plus nanoliposomal irinotecan (nal-IRI), has not been fully established. We retrospectively reviewed data from 17 patients with UR-PC who initiated 5-FU/l-LV plus oxaliplatin (FOLFOX) as salvage chemotherapy at our hospital between June 2020 and August 2021, after treatment with GnP and 5-FU/LV plus nal-IRI. The primary endpoint was tumor response. The secondary endpoints were progression-free survival (PFS) and adverse events (AEs). The response and disease control rates were 5.9% (1/17) and 17.6% (3/17), respectively. The median PFS was 1.8 months (range: 0.4–5.2 months). Eight patients (47.1%) experienced grade 3 nonhematologic AEs, while none experienced grade 3 hematologic AEs. Two patients with controlled disease had homologous recombination deficiency (HRD)-associated gene mutations in cancer panel testing. The FOLFOX regimen benefit for UR-PC patients treated with GnP and 5-FU/LV plus nal-IRI may be limited to patients with HRD-associated gene mutations.
P144 a Transforming Growth Factor Beta Inhibitor Peptide, Generates Antifibrogenic Effects in a Radiotherapy Induced Fibrosis Model
Authors: Cruz-Morande Sebastián , Dotor Javier , San-Julian Mikel
Published: April 2022

Radiation-induced fibrosis (RIF) is a severe side effect related with soft tissues sarcomas (STS) radiotherapy. RIF is a multicellular process initiated primarily by TGF-β1 that is increased in irradiated tissue, whose signaling leads to intracellular Smad2/3 phosphorylation and further induction of profibrotic target genes. P144 (Disetertide©) is a peptide inhibitor of TGF-β1 and is proposed as a candidate compound for reducing RIF associated wound healing problems and muscle fibrosis in STS. Methods: A treatment and control group of WNZ rabbits were employed to implement a brachytherapy animal model, through catheter implantation at the lower limb. Two days after implantation, animals received 20 Gy isodosis, intended to induce a high RIF grade. The treatment group received intravenous P144 administration following a brachytherapy session, repeated at 24–72 h post-radiation, while the control group received placebo. Four weeks later, affected muscular tissues underwent histological processing for collagen quantification and P-Smad2/3 immunohistochemistry through image analysis. Results: High isodosis Brachytherapy produced remarkable fibrosis in this experimental model. Results showed retained macro and microscopical morphology of muscle in the P144 treated group, with reduced extracellular matrix fibrosis, with a lower area of collagen deposition measured through Masson’s trichrome staining. Intravenous P144 also induced a significant reduction in Smad2/3 phosphorylation levels compared with the placebo group. Conclusions: P144 administration clearly reduces RIF and opens a new potential co-treatment approach to reduce complications in soft tissue sarcoma (STS) radiotherapy. Further studies are required to establish whether the dosage and timing optimization of P144 administration, in different RIF phases, might entirely avoid fibrosis associated with STS brachytherapy.
Parenchymal Insults in Abuse—A Potential Key to Diagnosis
Authors: Caré Marguerite M.
Published: April 2022

Subdural hemorrhage is a key imaging finding in cases of abusive head trauma and one that many radiologists and radiology trainees become familiar with during their years of training. Although it may prove to be a marker of trauma in a young child or infant that presents without a history of injury, the parenchymal insults in these young patients more often lead to the debilitating and sometimes devastating outcomes observed in this young population. It is important to recognize these patterns of parenchymal injuries and how they may differ from the imaging findings in other cases of traumatic injury in young children. In addition, these parenchymal insults may serve as another significant, distinguishing feature when making the medical diagnosis of abusive head injury while still considering alternative diagnoses, including accidental injury. Therefore, as radiologists, we must strive to look beyond the potential cranial injury or subdural hemorrhage for the sometimes more subtle but significant parenchymal insults in abuse.
Structural Optimization of Heat Sink for Thermoelectric Conversion Unit in Personal Comfort System
Authors: Xue Wenping , Cao Xiao , Zhang Guangfa , Tan Gang , Liu Zilong , Li Kangji
Published: April 2022

Based on the research background of improving personal thermal comfort and promoting building energy efficiency, personal comfort systems (PCSs) have recently received considerable attention. The thermoelectric conversion unit (TECU) has great potential in PCSs as it is compact in size, environmentally friendly and highly reliable. Aiming to improve heat exchange efficiency, this paper investigates the structural optimization of heat sink for the TECU used in PCSs. Firstly, the heat exchange mechanism of the thermoelectric module is analyzed. The structural design of the cold-side heat sink in the TECU is summarized as a multiobjective optimization problem in which four structural parameters (number of fin rows, fin thickness, fin height and thickness of base) of the heat sink are selected as the adjusting variables. Then, based on the establishment of the cold-side computational fluid dynamics simulation model, a multiobjective genetic algorithm is utilized for the optimization task. Sensitivity analysis demonstrates that the number of rows and the fin thickness have significant influence on the optimization objectives. Taking both the outlet airflow temperature and the velocity into consideration, five representative heat sinks involving two different materials are customized. A testing platform is built for performance comparison. Results show that the proposed optimization method can effectively improve the heat exchange efficiency of a TECU, which provides a reference for the TECU-based PCS design.
Sustainable Development Perspectives of Solar Energy Technologies with Focus on Solar Photovoltaic—A Review
Authors: Izam Najwa Syahirah Mohamed Nor , Itam Zarina , Sing Wong Leong , Syamsir Agusril
Published: April 2022

This study examines the sources of energy related carbon dioxide (CO2) emissions, the hazards of climate change and greenhouse gas (GHG) emissions, the global solar energy potential, renewable energy sustainability indicators, impediments, and the environmental implications of fossil fuels. The purpose of this study is to investigate viewpoints on solar energy technologies for sustainable development, with a particular emphasis on photovoltaic (PV), as well as the literature on solar energy technology performance, in order to ascertain worldwide solar energy adoption trends. The discussions address the solar industry’s fundamental ideas, the global energy scenario, the highlights of research conducted to improve the solar industry, prospective applications and future challenges for a more efficient solar industry that may help alleviate the energy crisis. A review of the framework and development of Renewable Energy Sources (RES) and Renewable Energy Laws (REL) on a global scale was conducted.
Exploring Quantum Machine Learning and Feature Reduction Techniques for Wind Turbine Pitch Fault Detection
Authors: Correa-Jullian Camila , Cofre-Martel Sergio , San Martin Gabriel , Lopez Droguett Enrique , de Novaes Pires Leite Gustavo , Costa Alexandre
Published: April 2022

Driven by the development of machine learning (ML) and deep learning techniques, prognostics and health management (PHM) has become a key aspect of reliability engineering research. With the recent rise in popularity of quantum computing algorithms and public availability of first-generation quantum hardware, it is of interest to assess their potential for efficiently handling large quantities of operational data for PHM purposes. This paper addresses the application of quantum kernel classification models for fault detection in wind turbine systems (WTSs). The analyzed data correspond to low-frequency SCADA sensor measurements and recorded SCADA alarm logs, focused on the early detection of pitch fault failures. This work aims to explore potential advantages of quantum kernel methods, such as quantum support vector machines (Q-SVMs), over traditional ML approaches and compare principal component analysis (PCA) and autoencoders (AE) as feature reduction tools. Results show that the proposed quantum approach is comparable to conventional ML models in terms of performance and can outperform traditional models (random forest, k-nearest neighbors) for the selected reduced dimensionality of 19 features for both PCA and AE. The overall highest mean accuracies obtained are 0.945 for Gaussian SVM and 0.925 for Q-SVM models.
The Role of Local Aggregator in Delivering Energy Savings to Household Consumers
Authors: Luttenberger Marić Leila , Keko Hrvoje , Delimar Marko
Published: April 2022

Energy communities, also known as renewable or citizen energy communities, can be a source of innovative aggregation solutions at the local level. The unleashed flexibility potential of households could provide self-balancing services for local energy communities or create new revenue streams for local flexibility aggregators. This paper proposes a methodology for the assessment of the energy savings potential of residential customers, factoring in local climatological conditions, energy consumption patterns, and building energy performance when the available input data are scarce. For baseline consumption modelling, the correlation between historical energy consumption data collected from a survey, building energy performance parameters, and the availability of flexibility assets was determined, taking into account the inconsistency between the quantity and quality of collected data from various consumers. For this purpose, a modelling approach using calculations for “Agent” buildings was used. In this way, each building user was assigned to a specific “Agent” with dedicated consumption characteristics for a flexibility asset. The capacities engaged in a flexibility programme were modelled according to the available flexibility assets, whilst the duration of a flexibility demand response (DR) event was considered a function of building energy performance characteristics, and consequently, activation strategies were applied. Additionally, several energy savings activation scenarios were modelled to interlink technical and behavioural constraints of household consumers. These constraints restrict the available flexibility, thus influencing the possibility of daily repetitions of a DR event and increasing savings with flexibility event activation. This model is intended to optimise flexibility assets provided by the end-users and, in this manner, deliver permanent energy savings, offering new business opportunities for aggregators or local energy communities. The novelty of this research is the recognition of an aggregator as a permanent energy savings provider, even if the obtained savings are very conservative per individual flexibility asset. Nevertheless, if properly aggregated and identified, the obtained savings could create novel business opportunities for a local aggregator.
Fault Diagnosis Method of Waterproof Valves in Engineering Mixing Machinery Based on a New Adaptive Feature Extraction Model
Authors: Zhang Rui , Yi Jiyan , Tang Hesheng , Xiang Jiawei , Ren Yan
Published: April 2022

Due to the complex working medium of oil in construction engineering, the waterproof valve in mixing machinery can easily cause different degrees of failure. Moreover, under adverse working conditions and complicated noise backgrounds, it is very difficult to detect the fault of waterproof valves. Thus, a fault diagnosis method is proposed, especially for the fault detection of waterproof valves as a key component in the construction of mixing machinery. This fault diagnosis method is based on a new adaptive feature extraction model, with multi-path signals to the improved deep residual shrinkage network–stacked denoising convolutional autoencoder (named DRSN–SDCAE). Firstly, the noisy vibration signals collected by the two vibration sensors are preprocessed, and then transmitted to the parallel structure improved DRSN–SDCAE for adaptive denoising and feature extraction. Finally, these results are fused through the feature fusion strategy to realize the effective fault diagnosis of the waterproof valve. The effectiveness of this method was verified through theory and experiments. The experimental results show that the proposed fault diagnosis method based on the improved DRSN–SDCAE model can automatically and effectively extract fault features from noise for fault diagnosis without relying on signal processing technology and diagnosis experiences. When compared with other intelligent fault diagnosis methods, the features extracted from multi-path inputs were more comprehensive than those extracted from single-path inputs, and contained more complete features of hidden data, which significantly improved fault diagnosis accuracy based on these fault features. The contribution of this paper is to learn fault features autonomously in signals with strong and complex noise through a deep network structure, which extends the fault diagnosis method to the field of construction machinery to improve the safe operation and maintainability of engineering machinery.
Correcting for Random Budgets in Revealed Preference Experiments
Authors: Mahmood Mir Adnan , Rehbeck John
Published: April 2022

Experiments on revealed preference often use budget sets that are randomly and independently drawn according to some criteria for each participant. However, this means that the budget sets faced by different individuals are not the same. This paper proposes a method to control for these differences. In particular, we control for the “power” of different budget sets by examining the consistency of an individual’s choices relative to some simulated baseline behavior conditional on budgets faced by the individual. We apply this methodology to two existing experimental datasets. Our results show that failure to account for this variation results in a bias when looking directly at measures of choice consistency and the sign of this bias depends on the measure being used. However, controlling for this variation does not change the correlation between measures of choice consistency and observable demographic characteristics like income and education.
Comparative Proteomic Analysis of Two Contrasting Maize Hybrids’ Responses to Low Nitrogen Stress at the Twelve Leaf Stage and Function Verification of ZmTGA Gene
Authors: Wang Yafei , Wang Nan , Liu Songtao , Dong Anyi , Zenda Tinashe , Liu Xinyue , Li Jiao , Duan Huijun
Published: April 2022

Nitrogen is one of the essential nutrients for plant growth and development. However, large amounts of nitrogen fertilizer not only increase the production costs, but also lead to serious environmental problems. Therefore, it is particularly important to reduce the application of nitrogen fertilizer and develop maize varieties with low nitrogen tolerance. The aim of this study was to determine the phenotypic and proteomic alterations of maize affected by nitrogen deficiency and to elucidate the molecular and physiological mechanisms underpinning maize tolerance to low nitrogen. Two maize hybrids with contrasting low nitrogen tolerance were used as the experimental materials. Maize plants were grown under different nitrogen application levels (N0 and N240) and proteomic analysis performed to analyze leaf differentially abundant proteins (DAPs) under different nitrogen conditions. The results showed that under the nitrogen deficiency condition, the nitrogen content, leaf dry weight, leaf area, and leaf area index of XY335 decreased by 15.58%, 8.83%, 3.44%, and 3.44%, respectively. However, in the variety HN138, the same parameters decreased by 56.94%, 11.97%, 8.79%, and 8.79%, respectively. Through proteomic analysis, we found that the low nitrogen tolerance variety responded to low nitrogen stress through lignin biosynthesis, ubiquitin-mediated proteolysis, and stress defense proteins. Transmembrane transporters were differentially expressed in both hybrids after low nitrogen treatment, suggesting that this was a common response to low nitrogen stress. Using bioinformatics analysis, we selected the key candidate gene (ZmTGA) that was assumed to respond to low nitrogen stress, and its function was characterized by maize mutants. The results showed that when compared with normal nitrogen treatment, the root length of the mutants under low nitrogen treatment increased by 10.1%, while that of the wild-type increased by 14.8%; the root surface area of the wild type under low nitrogen treatment increased by 9.6%, while that of the mutants decreased by 5.2%; the root surface area of the wild type was higher than that of the mutant at both nitrogen levels; and the activities of glutathione and guaiacol peroxidase enzymes in the mutant were lower than those in the wild-type under low nitrogen treatment. In summary, the mutant was less adaptable to a low nitrogen environment than the wild type. Our results provide maize genetic resources and a new direction for a further understanding of maize response to low nitrogen stress.
hMSH5 Regulates NHEJ and Averts Excessive Nucleotide Alterations at Repair Joints
Authors: Al-Soodani Aneesa T. , Wu Xiling , Kelp Nicole C. , Brown Alexander J. , Roberts Steven A. , Her Chengtao
Published: April 2022

Inappropriate repair of DNA double-strand breaks (DSBs) leads to genomic instability, cell death, or malignant transformation. Cells minimize these detrimental effects by selectively activating suitable DSB repair pathways in accordance with their underlying cellular context. Here, we report that hMSH5 down-regulates NHEJ and restricts the extent of DSB end processing before rejoining, thereby reducing “excessive” deletions and insertions at repair joints. RNAi-mediated knockdown of hMSH5 led to large nucleotide deletions and longer insertions at the repair joints, while at the same time reducing the average length of microhomology (MH) at repair joints. Conversely, hMSH5 overexpression reduced end-joining activity and increased RPA foci formation (i.e., more stable ssDNA at DSB ends). Furthermore, silencing of hMSH5 delayed 53BP1 chromatin spreading, leading to increased end resection at DSB ends.
Determinants of Late HIV Presentation at Ndlavela Health Center in Mozambique
Authors: Chone Jeremias Salomão , Abecasis Ana Barroso , Varandas Luís
Published: April 2022

Background: There has been tremendous progress in the fight against HIV worldwide; however, challenges persist in the control of HIV infection. These challenges include the high prevalence of late presenters. There are many disadvantages of late presentation—from reduced survival of the infected person to the risk of transmitting the infection. This research aims to analyze the factors that influence the late presentation in patients attending Ndlavela Health Center in Mozambique. Methodology: A retrospective cross-sectional study was carried out at Ndlavela Health Center including patients diagnosed with HIV between 2015 and 2020. The European Late Presenter Consensus working group definitions were used, and univariate and multivariate logistic regression were used to identify factors associated with late presentation. Results: In total, 519 participants were included in the study, of which nearly 47% were classified as late presenters. The male gender (AOR = 2.41), clinical suspicious test (AOR = 4.03), initiated by the health professional (AOR = 2.1,9), and fear of stigma (AOR = 2.80) were the main risk factors for late HIV presentation. Conclusion: Factors that are potentially determinant for late HIV presentation were identified. Actions are needed to focus on risk factors that are most likely to delay presentation.
Comparing the Effect of Methylphenidate and Anodal tDCS on Inhibitory Control and Working-Memory in Children and Adolescents with Attention Deficit/Hyperactivity Disorder: A Study Protocol for a Randomized, within-Subject Trial
Authors: D’Aiello Barbara , Battisti Andrea , Lazzaro Giulia , Pani Pierpaolo , De Rossi Pietro , Di Vara Silvia , Pretelli Italo , Costanzo Floriana , Vicari Stefano , Menghini Deny
Published: April 2022

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by inappropriate levels of attention, hyperactivity, and impulsivity that interfere with individual functioning. The international guidelines recommend targeting ADHD-related neurochemical brain abnormalities by intervening via drug treatment, such as methylphenidate (MPH), as first choice. Drug treatments are usually associated with a huge amount of cost for families and the healthcare system, suspension for low compliance, poor long-term efficacy, and side effects. Transcranial direct current stimulation (tDCS) has been suggested as a possible noninvasive means to safely manipulate brain activity and, in turn, improve behavior and cognition in developmental ages. Several studies have shown that tDCS has the potential to improve ADHD-related cognitive deficits, but the effect of tDCS compared with MPH has never been evaluated. The aim of the present within-subject, sham-controlled, randomized proof-of-concept study is to demonstrate the positive effect of one-session anodal tDCS analogous to the MPH drug on inhibitory control and working memory in children and adolescents with ADHD. We strongly believe that this study protocol will serve to accelerate research into low-cost, drug-free, feasible interventions for ADHD.