bluuebunny/crossref_metadata_2025 huggingface dataset:
A Feasibility Study on a Multidisciplinary Rehabilitation Program Including Whole-Body Cryostimulation in Patients With Obesity and Post-COVID Condition
Authors: Fontana Jacopo Maria , Alito Angelo , Piterà Paolo , Verme Federica , Cattaldo Stefania , Cornacchia Mauro , Mai Stefania , Brunani Amelia , Capodaglio Paolo
Published: October 2023

Background: Post-Covid condition can reduce activity and quality of life, resulting in a significant socioeconomic and health burden. Understanding its impact on patients' health is important for the development of personalized rehabilitation interventions. An independent association between obesity and post-covid condition was found because of complications and comorbidities. Methods: Sixteen patients with obesity and post-COVID symptoms (i.e., dyspnea, pain, poor sleep quality, muscle fatigue) admitted to the Istituto Auxologico Italiano, Piancavallo (VB), Italy, were recruited for a four-week rehabilitation program including conventional exercise therapy, nutritional intervention, psychological support and whole-body cryostimulation (WBC). Results: All participants attended all sessions of the program. Anthropometric data showed statistically significant changes in weight, waist circumference and body mass index. Biochemical analyses showed significant reductions in lipid and inflammatory profiles. There was a significant improvement in physical performance, reduction in pain and improvement in psychological well-being. Conclusion: A multidisciplinary rehabilitation protocol including WBC designed for patients with obesity and post-covid condition is safe and feasible. The overall improvements demonstrate that multidisciplinary rehabilitation was effective on post COVID patients and suggest that the use of WBC is safe and could play a role as a booster in rehabilitation programs.
Why Honey Bees Are Dying: A Forgotten Cause
Authors: Alphen Jacques J. M. van
Published: October 2023

This article explains how resistance alleles have become rare or have disappeared from honey bee populations in Europe (and probably also in North America). Honeybees have the highest recombination frequency of all animals, indicating that pathogenic bacteria, viruses, fungi and microsporidia are an important source of selection. To respond to new virulent strains of pathogens, honeybees need to have access to rare alleles that could foster immunity against a new pathogen. By mating in a large panmictic population, new rare alleles can be recruited, which can then be combined into new genotypes through recombination with useful alleles of other genes. Bee breeders, by selecting small samples from a large population tend to select common alleles and lose the rare ones. Rare alleles can become important when a new virulent pathogen arrives. The loss of rare alleles makes bees vulnerable to disease and parasites and explains, together with the problems caused by modern agriculture, why managed bees have high mortality rates.
Testing Various Cement Formulations under Temperature Cycles and Drying Shrinkage for Low-Temperature Geothermal Wells
Authors: Fischer Hartmut , Moghadam Al
Published: October 2023

Keywords: keyword 1; keyword 2; keyword 3 (List three to ten pertinent keywords specific to the article yet reasonably common within the subject discipline.)
Effect of modes of laser irradiation on antimicrobial photodynamic therapy (aPDT) for Streptococcus sobrinus in the crown dentin of bovine teeth: an experimental in vitro study
Authors: Yamaguchi Yohei , Yoshii Daiki , Katsuragi Hiroaki , Shinkai Koichi
Published: October 2023

This study aimed to assess the impact of different modes of laser irradiation on the bactericidal efficacy of aPDT. Dentin plates were prepared by sectioning the crown dentin of bovine teeth infected with Streptococcus sobrinus. Nine aPDTs involving the combinations of three photosensitizers (brilliant blue, BB; acid red, AR; and methylene blue, MB) and three laser irradiation modes (50 mW for 120 s, 100 mW for 60 s, and 200 mW for 30 s) were performed for each infected dentin plate, and the control group consisted of the specimens not applied with aPDT. The bactericidal effects in 10 experimental groups were evaluated (n=11) using both assays of the colony-count and adenosine triphosphate (ATP). The data obtained were analyzed using the Kruskal-Wallis test. The aPDT performed with semiconductor laser in combination with BB, AR, and MB exerted a remarkable bactericidal effect. aPDT with MB exerted a more significant bactericidal effect in the colony-count assay. The results of aPDT performed with varying irradiation times and powers but with constant irradiation energy showed no difference with AR and MB between the modes, whereas BB showed a more significant bactericidal effect when irradiated for a shorter time at a higher irradiation power.
A Steady State Preserving Numerical Scheme for One-Dimensional Blood Flow Model
Authors: Vega Carlos Arturo , Valbuena Sonia , Bojato Jesus Blanco
Published: October 2023

In this work, an entropy-stable and well-balanced numerical scheme for a one-dimensional blood flow model is presented. Such scheme is obtained from an explicit entropy conservative flux along with a second order discretization of the source term by using centered finite differences. We prove that the scheme is entropy-stable and preserves steady-states solutions. In addition, some numerical examples are included to test the performance of the proposed scheme.
Holistic View and Novel Perspective on Ruminal and Extra-gastrointestinal Methanogens in Cattle
Authors: Aryee Godson , Luecke Sarah M , Dahlen Carl R , Swanson Kendall C , Amat Samat
Published: October 2023

Despite the extensive research conducted on ruminal methanogens and anti-methanogenic intervention strategies over the last 50 years, most of the currently researched enteric CH4 abatement approaches have shown limited efficacy. This is largely because of the complex nature of animal production and the ruminal environment, host genetic variability of CH4 production, and an incomplete understanding of the role of the ruminal microbiome in enteric CH4 emissions. Recent sequencing-based studies suggest the presence of methanogenic archaea in extra-gastrointestinal tract tissues, including respiratory and reproductive tracts of cattle. While these sequencing data require further verification by culture-dependent methods, the consistent identification of methanogens with relatively greater frequency in the airway and urogenital tract of cattle plus increasing appreciation of the microbiome-gut-organ axis highlight the potential interactions between ruminal and extra-gastrointestinal methanogenic communities. Thus, a traditional singular focus on ruminal methanogens may not be sufficient, and a holistic approach which takes into consideration of the transfer of methanogens between ruminal, extra-gastrointestinal, and environmental microbial communities is of necessity to develop more efficient and long-term ruminal CH4 mitigation strategies. In the present review, we provide a holistic survey of the methanogenic archaea present in different anatomical sites of cattle and discuss potential seeding sources of the ruminal methanogens.
Iron-Added Aluminum Matrix Composites Prepared by Friction Stir Processing: Structure, Mechanical and Tribological Properties
Authors: Knyazhev Evgeny , Nikolaeva Aleksandra , Chumaevskii Andrey , Cheremnov Andrey , Zykova Anna , Gurianov Denis , Utyaganova Veronika , Moskvichev Evgeny , Savchenko Nickolai , Tarasov Sergei
Published: October 2023

Structural evolution, mechanical and tribological properties of Al-Mg alloy admixed with 5, 10 and 15 vol.% of iron powder using multi-pass friction stir processing (FSP) have been studied. Homogeneous distribution of intermetallic compound (IMC) particles were achieved after 4 FSP passes what resulted in increasing the stir zone hardness and ultimate tensile stress with simultaneous loss in the ductility. The reinforcement of the aluminum alloy matrix with IMCs allowed reducing wear at the same magnitude of friction. Subsurface composite tribological layer was formed on the FSPed samples as a result of rubbing against a steel counterbody.
Review and Analysis of Energy-Efficient AC Voltage Regulators
Authors: Udovichenko Aleksey Vjacheslavovich , Grishanov Evgeniy Valer'evich , Kosykh Evgeniy Andreevich , Mekhtiyev Ali Dzhavanshirovich
Published: October 2023

The formation of the required AC voltage level is currently one of the most important problems. An unstable voltage level can lead to the failure of domestic and industrial equipment, also to the appearance of a lighting equipment flicker effect, which can adversely affect the operating mode. In this regard, the development of AC voltage regulators that perform the function of stabilizers has become relevant. In turn, new topologies should be energy efficient and reliable, this can be achieved by reducing the number of semiconductor elements, which in turn will reduce losses and increase efficiency. In addition to voltage stabilization, AC voltage regulators have found application as soft-start devices for asynchronous motors, and have become competitors to frequency converters. The power level can vary from units to tens of kilowatts where such devices can be used. This paper provides a review of AC voltage regulators, which can be used both as soft starters and AC voltage stabilizers. The analysis of the circuits was carried out and the efficiency was evaluated through their total harmonic distortions (THD), power factor and efficiency coefficient. Experiments were also performed for a number of circuits, where their operating modes were evaluated. Eventually, all circuits were divided into full number of switches with two or more AC switches per phase, with a reduced number of switches, where one AC switch per phase and with low number of switches – with one complementary pair of AC switches for all three phases.
Integrated Genomic Analysis of Primary Prostate Tumor Foci and Corresponding Lymph Node Metastases Identifies Mutations and Pathways Associated with Metastasis
Authors: Moreno Carlos S. , Winham Cynthia L. , Alemozaffar Mehrdad , Klein Emma R. , Lawal Ismaheel O. , Abiodun-Ojo Olayinka A. , Patil Dattatraya , Barwick Benjamin G. , Huang Yijian , Schuster David M. , Sanda Martin G. , Adeboye Osunkoya O.
Published: October 2023

Prostate cancer is a highly heterogeneous disease, and mortality is mainly due to metastases, but the initial steps of metastasis have not been well characterized. We have performed integrative whole exome sequencing and transcriptome analysis of primary prostate tumor foci and corresponding lymph node metastases (LNM) from 43 patients enrolled in clinical trial. We present evidence that while there are some cases of clonally independent primary tumor foci, 87% of primary tumor foci and metastases are descended from a common ancestor. We demonstrate that genes related to oxidative phosphorylation are upregulated in LNM and in African-American patients relative to White patients. We further show that mutations in TP53, FLT4, EYA1, NCOR2, CSMD3, and PCDH15 are enriched in prostate cancer metastases. These findings were validated in a meta-analysis of 3,929 primary tumors and 2,721 metastases and reveal a pattern of molecular alterations underlying the pathology of metastatic prostate cancer. We show that LNM contain multiple subclones that are already present in primary tumor foci. We observed enrichment of mutations in several genes including understudied genes such as EYA1, CSMD3, FLT4, NCOR2, and PCDH15 and find that mutations in EYA1 and CSMD3 are associated with poor outcome in prostate cancer.
A Travel through Landscapes of Seed Dormancy
Authors: Gianinetti Alberto
Published: October 2023

Basic features of seed dormancy are illustrated. The seed overall regulatory network governs seed metabolism and development, and it is coordinated by plant hormones. A functional model focused on abscisic acid (ABA), the foremost plant hormone in dormancy, is used as a framework to critically discuss the literature. Gibberellins (GAs) have a main role in germination, and the ABA – GAs balance is a typical feature of the seed state: ABA dominates during dormancy and GAs prevail through germination. Thus, the literature converges toward envisaging the development switch between dormancy and germination as represented by the ABA/GAs ratio. The ABA – GAs antagonism is based on mutual inhibition, a feature of the regulatory network architecture that characterizes development trajectories based on a regulatory circuit with a bistable switch. Properties of such kind of regulatory architecture are introduced step by step, and it is shown that seed development – towards either dormancy or germination – is more properly represented by a tristable regulatory circuit, whose intermediate metastable states ultimately take one or the other development trajectory. Although the ABA/GAs ratio can conveniently represent the state of the seed overall regulatory network along the seed development trajectory, specific (unknown) dormancy factors are required to determine the development trajectory. The development landscape is shown to provide a well-suited representation of seed states travelling along developmental trajectories, particularly when the states are envisioned as regulatory circuits. Looking at seed dormancy in terms of regulatory circuits and development landscapes offers a valuable perspective to improve our understanding of this biological phenomenon.
EVOLUTION OF UNDERSTANDING THE ROLE OF CHRONIC INFLAMMATION AS A KEY ELEMENT IN ASTHMA PATHOGENESIS
Authors:   Kazan State Medical University, KHAKIMOVA MILYAUSHA R.
Published: October 2023

ntroduction. Asthma is considered as a heterogeneous disease. Recently, the pathophysiological mechanisms of chronic airway inflammation development have been established. However, the evolution of understanding the asthma pathogenesis is a matter of great interest. Aim. Based on literature review, our aim was to provide the key milestones in the formation of modern understandings in asthma etiology and pathogenesis. Material and methods. We searched across PubMed and eLibrary.ru databases to identify articles published in 1900-2022, using the keywords ‘bronchial asthma’, ‘history’, ‘pathogenesis’, ‘eosinophilic inflammation’, ‘endotypes’, ‘biomarkers’, ‘innate lymphoid cells’ and ‘Th2 lymphocytes’. Results and discussion. Since ancient times scientists were interested in the mechanisms of asthma development. ‘Asthma’ derived from Greek word that means ‘shortness of breath’ and ‘suffocation’. In the Middle Ages, science was scholasticism oriented, so the understandings of asthma were based only on observational studies, and the works of Hippocrates and Galen were considered irrefutable. Subsequently, in Modern times observational studies were supported by experiments and that gave the opportunity to study the asthma pathogenesis. Since the 20th century studies on identifying the roles of heredity, sensitization and mechanisms of airway inflammation have flourished and that led to the identification of asthma endotypes and phenotypes. Recent trends in the understanding of pathogenesis at molecular levels provided a personalized approach to asthma treatment. Conclusion. Thus, accumulated clinical observational and experimental data gained new insights into asthma pathogenesis and led to the development of biologics for the management of asthma. This study was funded by grant from Kazan State Medical University N2/22-10 (02.08.2022).
EVALUATION OF THE INCIDENCE OF BRUCELLOSIS IN CHILDREN IN CONDITIONS OF INTENSIFICATION OF INDIVIDUAL LIVESTOCK BREEDING
Authors:   Azerbaijan Medical University, TAGHI-ZADEH TARANA GADIR
Published: October 2023

Introduction. Despite not huge efforts to combat brucellosis, in a number of countries, including Azerbaijan, decisive positive results have not yet been achieved. Many households began to keep livestock, which could lead to an increased risk of brucellosis in children. Aim. Assessment the influence of individualization of livestock breeding on the incidence of brucellosis in children. Material and methods. The work was carried out in 14 settlements of the Baku urban agglomeration located on the Absheron Peninsula. An epidemiological survey was carried out on 486 individual farms, selected by a blind method, 331 of them kept livestock. Serological diagnosis was carried out using the Huddleson and Wright tests. A total of 1702 children were examined, of which 533 children lived in households that did not contain livestock, 796 children lived in farms that kept livestock, and 373 children lived in village 2-7-storey buildings. When statistically processing the results of the study, the definition of Student’s t-criterion, χ² and correlation coefficient was used. Results and discussion. Infection of children averaged 15.2±0.9%, as the age of children (≤3>15 years) increases, it increases from 6.0±1.8 to 21.1±2.8%. The infection rate of children living in households with livestock is higher than without them - 10.5±0.7 and 2.8±0.4%. As the number of livestock increases, the infection rate in children increases from 9.1±4.4 to 29.6±2.1%. The seropositivity of children living in individual households that do not keep livestock and in village 2-7-stage buildings is approximately the same and amounts to 2.8±0.4 and 1.9±0.3%, respectively (t= 1.80; P>0.05) and is much inferior to the seropositivity of children living in individual households with livestock: 10.5±0.7% (t=9.63; P<0.001). Conclusion. The epidemiological situation of brucellosis among children has deteriorated in recent years, which is associated with the individualization of livestock breeding. Therefore, the search for new approaches to the prevention of brucellosis in the population should be carried out taking into account these changes.
VITAMIN D IN VARIOUS AGE-RELATED PATHOLOGY IN CENTENARIANS AND VERY ELDERLY PATIENTS WITH CORONARY ARTERY DISEASE
Authors:   First Moscow State Medical University, TOPOLYANSKAYA SVETLANA V. , MАMCHICH DARYA S. ,   First Moscow State Medical University, ELISEEVA TATYANA A. ,   War Veterans Hospital N3, Moscow, TURNA OLGA I. ,   War Veterans Hospital N3, Moscow, ROMANOVA MARGARITA A. ,   War Veterans Hospital N3, Moscow, VAKULENKO OLGA N. ,   War Veterans Hospital N3, Moscow, BUBMAN LEONID I. ,   War Veterans Hospital N3, Moscow, KOSHURNIKOV DMITRY S. ,   War Veterans Hospital N3, Moscow, LYTKINA KARINA A. ,   War Veterans Hospital N3, Moscow, MELKONYAN GEORGYI G. ,   War Veterans Hospital N3, Moscow, VAKOLUK ROSA M. ,   First Moscow State Medical University, RATCHINA SVETLANA A. ,   First Moscow State Medical University, DVORETSKI LEONID I. ,   First Moscow State Medical University
Published: October 2023

Introduction. Vitamin D deficiency is associated with many pathological conditions. The elderly is at high risk of vitamin D deficiency due to their reduced ability to produce vitamin D precursors in the skin. Aim. To analyze 25-Hydroxycalciferol relationships with various clinical and laboratory parameters in centenarians and very elderly patients with coronary artery disease. Material and methods. This work was cross-sectional study. The study included 230 patients aged 76 to 99 years, hospitalized with the diagnosis of coronary heart disease. The concentration of 25-hydroxycalciferol was determined by immunochemiluminescent analysis. A 25-hydroxycalciferol level <10 ng/mL was considered as severe vitamin D deficiency, 10-19 as deficiency, 20-29 as insufficiency, and ≥30 ng/mL as normal. Results and discussion. The mean 25-Hydroxycalciferol concentration was 14.9+10.2 ng/mL. Only 7.5% of patients had normal 25-Hydroxycalciferol level, 12.3% - insufficiency, 43.6% - deficiency, 36.6% - severe vitamin deficiency. In centenarians the mean concentration of vitamin D was 12.9+9.9 ng/ml, in patients <90 years – 16.4+10.2 ng/ml (p=0.01). Significant positive correlations were registered between vitamin D level and hand grip strength measured by dynamometry (r=0.2; p=0.008) and the instrumental activity scale (r=0.1; p=0.03). The mean level of vitamin D in the group of patients with high risk of cognitive impairment was 11.2+5.8 ng/ml, with low risk of cognitive impairment – 20.8+18.5 ng/ml (p<0.0001). Negative correlations were registered between 25-Hydroxycalciferol level and the Morse fall scale (r=-0.2, p=0.03). Significant direct correlation between serum uric acid and vitamin D was registered (r=0.3; p=0.001). No significant relationships were found between vitamin D levels and bone mineral density in various parts of the skeleton, with the exception of the T-score in the lumbar spine in centenarians (р=0.004). Conclusion. The study results indicate presence of various relationships between 25-Hydroxycalciferol blood concentration and various clinical and laboratory parameters in centenarians and very elderly patients with coronary artery disease and, above all, with functional insufficiency, cognitive impairment and hyperuricemia.
MECHANISMS OF THROMBO-INFLAMMATION IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS
Authors:   Kazan State Medical University, ISMAGILOVA REZIDA R. , MAKSUDOVA ADELYA N. ,   Kazan State Medical University, ZUBAIROVA LYAYLI D. ,   Kazan State Medical University, NABIULLINA ROZA M. ,   Kazan State Medical University
Published: October 2023

Introduction. Systemic lupus erythematosus (SLE) is a systemic autoimmune inflammatory disease. According to different authors, the incidence of thrombotic complications in this disease is higher than the average in the population and can be up to 40%. Aim. The aim of the present review is to provide an overview of mechanisms of thrombosis in patients with systemic lupus erythematosus. Material and methods. Analytical review of foreign and native publications in PubMed and eLibrary.ru between 1985-2020. Results and discussion. SLE represents a model of inflammation-induced thrombosis. The hypercoagulability state which characterizes SLE seems to be associated with inflammation-driven alterations of the thrombotic balance. Tissue-nonspecific autoantibodies, as well as cytokines and acute phase proteins induce a proinflammatory endothelial cell phenotype. Platelets are activated following endothelial dysfunction; they participate in inflammatory and thrombotic events occurring in an injured area. One of the possible initiators of the thrombosis process is considered to be an interaction of antiphospholipid antibodies with phospholipids of platelet membranes, endothelium and phospholipid-linked plasma proteins. Local unbalanced thrombin generation leading to hypercoagulability is another source central for thrombosis. Patients with systemic lupus erythematosus show multidirectional disorders of the coagulation system, with predominance of hypercoagulation especially in patients with II-III degree of disease activity. Conclusion. The mechanism of thrombo-inflammation in systemic lupus erythematosus is multifactorial, involving all components of the hemostatic system. Chronic endothelial dysfunction, platelet activation, hypercoagulation, suppression of fibrinolysis reflects an interplay between thrombosis and inflammation. Persisting autoimmune inflammation plays a key role in these abnormalities.
Critical Incidents in Ways of Experiencing Ethical Engineering Practice

Authors: Hess Justin L. , Kim Dayoung , Fila Nicholas D.
Published: October 2023

Background: Ethics is a required outcome for engineering education programs, but few studies focus on how workforce experiences lead to changes in how engineers experience ethics in practice. By identifying what incidents influence the ways that engineers come to experience ethical engineering practice, we can more effectively design post-secondary pedagogy based on these experiences.
Purpose: We address the research question, “What types of critical incidents influence engineers’ ways of experiencing ethical engineering practice?” By identifying and categorizing critical incidents, we aim to provide the engineering education community with strategies and stories that they can embed in post-secondary engineering ethics curriculums.
Design/Method: We employed a semi-structured interview protocol to solicit experiences with ethical engineering practice among 43 engineers from a variety of engineering disciplines and who were all currently working in the health products industry. While the interviews focused on ways of experiencing ethical engineering practice, many participants discussed critical change-inducing incidents therein. Thus, we used critical incident technique to identify and synthesize influential workforce experiences in their ethical practice.
Results We identified 106 critical incidents, or workforce experiences that led to a change in how engineers viewed or practiced ethical engineering. We grouped incidents into 17 critical incident types, which represent patterns of events or behaviors that led to a change or reinforcement in ethical practice. We grouped incident types into five categories: (1) Cultural Immersions, (2) Interpersonal Encounters; (3) Ethical Actions, (4) Ethical Failures, and (5) Mentorship Events.
Conclusion: This study can inform educational change efforts by ensuring that such efforts are grounded in and based on the lived experiences of practicing engineers. We found that Cultural Immersions was the most prominent type of critical incident among participants, and thus we emphasize the import of supporting student awareness of organizational culture, including how it informs one’s ethical views and practices. Based on the range of incident types, we also emphasize how instructors might consider and build the multitude of incident types and categories to implement pedagogy aligned with workforce experiences.
Corporate entrepreneurial orientation and absorptive capacity as determinant of firm performance
Authors: Bernardus Denny
Published: October 2023

This study examines the complicated relationship between company performance, absorptive ability, and corporate entrepreneurial orientation, taking institutional age into account. This research employs data analysis approaches utilizing variance-based structural equation modeling techniques (PLS-SEM). When absorptive capacity and corporate entrepreneurial orientation are high, firms under 10 years of age are anticipated to outperform older ones. Effective information absorption and entrepreneurial orientation help emerging institutions capitalize on external knowledge and sustain their entrepreneurial spirit. This study underlines the need for empirical research to support theoretical ideas by addressing industry dynamics, organizational culture, and leadership styles. Such a study would inform strategic decision making and organizational practices, helping institutions operate better in dynamic commercial situations.
Cumhuriyet Dönemi Alışveriş Kültüründe Alışveriş Merkezlerinin Hakimiyeti: Birinci Yüzyılın Meşruiyet Kaynakları, İkinci Yüzyılın Başında Olası Değişimler
Authors: KARAPOLATGİL Ahmet Anıl , ŞENER İrge
Published: October 2023

Tarih boyunca Anadolu coğrafyası alışveriş kültürünün gelişmesinde belirleyici rol oynamıştır. Farklı medeniyetler alışveriş faaliyetleri için özel alanlar inşa etmişler ve Anadolu'nun bir sonraki hakimine zengin bir alışveriş kültürünü miras bırakmışlardır. Türkiye Cumhuriyeti’nin ilk 100 yılında bu miras farklı öğeler ile devam ettirilmiş fakat ilk temsilcisi 1988'de açılan AVM’ler kısa sürede yaygınlaşmış ve Anadolu'da alışveriş kültürünün lider öğesi olmuşlardır. Bu çalışmada AVM’lerin lider konumlarının ardındaki nedenlerin incelenmesi hedeflenmiş ve ikincil veriler temelinde eşbiçimlilik kavramı çerçevesinde değerlendirmeler yapılmıştır. Bu bağlamda, AVM’lerin Anadolu'nun alışveriş kültürünün başarılı tarihi temsilcilerinin özellikleri ile global kabul görmüş standartları bir araya getirerek meşruiyetlerini korudukları ve eşbiçimlilik özelliklerini geliştirdikleri tespit edilmiştir. Ayrıca, glokal özelliğe sahip AVM’lerin yeni taleplere daha kolay uyum göstereceği ve Anadolu alışveriş kültürünün gelecekteki lider unsuru olacağı çıkarımı yapılmıştır.
Da’wah al-Ṣūfiyyah wa Taṭawwur al-Islām fī Indonesia: Dirāsah Ḥaula Ta’tsīr wa Musāhamah ‘Ulamā’ al-Ṣūfiyyah fī Ta’zīz al-Qiyam al-Islāmiyyah wa Nashrihā
Authors: Saleh Malikus , Ichsan Muhammad , Izzatullah Hujjatul Islam Musthafa Abdurrahman Faiz
Published: October 2023

The propagation of Islamic faith, or da’wah, in Indonesian archipelago had gone through a lengthy historical process. Various methods and approaches were taken to consolidate its place among the Indonesian people who were long-time believers of animism, dynamism,Hinduism, and Buddhism among others. One of such methods is the Sufi-based da’wah, which played a vital role in dissemination of Islamic faith through acculturation of its valuesinto the older beliefs. The purpose of this research is to study the Indonesian sufi community’s da’wah endeavor and the religio-cultural challenges they had faced. With the descriptive analytic and historical methods approaches, this research identifies and analyzes the works of prominent Indonesian sufi scholars which had contributed to the widespread acceptance of Islamic faith and its values. The conclusion of this research has found that there is indeed a significant influence coming from Indonesian sufi scholars toward the propagation of Islamic faith and its values, along with its consolidation and preservation therein. Thus, the result can be regarded as an effort to better understand the role of tasawuf in propagating the Islamic faith in Indonesia. Hopefully the result of this research shall deepen the understanding of the role of tasawuf in encouraging the dissemination of Islamic faith in Indonesia.
Development and optimization of PCR assay to identify fish fraud
Authors: Silva J.J. , Iamanaka B.T.
Published: October 2023

Fish fraud, characterized by intentional mislabeling or substitution of fish species for economic gain, poses significant risks to public health, food safety, and the integrity of the seafood industry. Effective detection methods are crucial to combat this fraudulent activity. This protocol outlines the development of a novel PCR assay, utilizing a new set of primers optimized for the precise identification of species frequently involved in frauds within the Brazilian fisheries sector, namely salmon, tilapia, and cod. The primer sets were designed based on a comprehensive dataset of mitochondrial DNA sequences, specifically the locus COX1 (cytochrome c oxidase subunit I). By implementing this robust PCR-based approach, the Brazilian fisheries sector can significantly enhance traceability and authenticity verification in their supply chain. Consumers' confidence will be safeguarded, and fair business practices can be promoted, ultimately fostering sustainability in the industry. This assay offers a practical and effective tool to tackle fish fraud and support efforts to maintain the integrity of the fisheries sector in Brazil.
Impact of Artificial Intelligence assisted Drug Therapy Optimization on Drug related problems Amongst Elderly Patients: A Systematic Review
Authors: Syed Jehath , Thomas Christy , Kaur Bavneet , Undela Krishna , Chalasani Sri Harsha , Madhan Ramesh , M Pramod Kumar T , Patil Vikram , Pereira Prathibha , J Tejeswini C , Avarebeel Shilpa , Ramesh Kshama
Published: October 2023

DRPs are associated with higher healthcare costs and hospital admissions, longer hospital stays, lower quality of life and higher mortality. Therefore, special considerations must be made when prescribing and using medicines in older patients, such as avoiding inappropriate medicines, monitoring side effects, avoiding drug-drug interactions, and assessing adherence and patient participation.
In recent years, there has been increasing interest in the use of clinical decision support systems to support prescribing. Computerised interventions have been reported to be more effective than traditional educational interventions delivered by prescribers or those where a pharmacist reviewed the medication. This review critically appraises studies looking at artificial intelligence-assisted optimisation of drug therapy in hospitalized elderly patients.
Following the PRISMA guidelines, we will conduct a systematic review that includes three databases: PubMed, Google Scholar and Scopus. The proposed review will include randomized, non-randomized, and cohort studies. Study types such as literature reviews, letters to the editor, pilot studies and short communications will be excluded from the review. We will summarise the available evidence on the effectiveness of computer-assisted interventions in identifying DRPs in hospitalised older patients, and the frequency, nature, and acceptance rate of computer-assisted recommendations.
Experiences of rural clinicians accessing specialist support via telehealth for trauma and emergency care in Queensland, Australia
Authors: Santomauro Chiara , McLanders Mia , Rae Andrew
Published: October 2023

Objective: Trauma and emergency patients presenting to rural facilities require time-critical treatment and management that is sometimes beyond the scope of clinicians in the facility. In Queensland, Australia’s second largest state, telehealth infrastructure facilitates 24/7 communication between rural clinicians and tertiary-based critical care specialists. We sought to understand the current state of Queensland’s emergency telehealth system from the perspective of direct end-users to inform future improvement efforts and resource allocation.
Methods: Semi-structured interviews were conducted with 11 rural Queensland clinicians who use telehealth to access specialist support during critical presentations. Qualitative data were analysed in three inductive phases: immersion; a combination of process coding and in vivo coding; and focused coding.
Results: The findings highlight that emergency telehealth support provides benefits beyond better patient care, as it fosters collegiality and alleviates professional isolation. Four key themes were identified: (1) Challenges of trauma and emergency care in rural Queensland; (2) Strategies for trauma and emergency care in rural Queensland; (3) Factors that affect perceptions of telehealth effectiveness; and (4) How support for rural trauma and emergency care can be improved.
Conclusions: There are both benefits and frustrations for rural clinicians accessing telehealth specialist support for critical care. Although telehealth is seen as a vital service that supports rural clinicians and benefits patient care, the findings suggest that tools, systems, and processes surrounding rural trauma and emergency care could benefit from streamlining, integration, and the introduction of fit-for-purpose technologies. Addressing limitations of efficiencies would improve support for rural clinicians and likely improve patient outcomes for rural communities.
Prevalence and factors associated with Enuresis among children with Sickle Cell Anaemia attending Sickle Cell Clinic at Mulago National Referral Hospital; A Cross sectional study.
Authors: Kuteesa Mary Goretty , Abbo Catherine , Kasirye Philip , Kaudha Gloria , Wachepa Stella , Owomugisha Gloria , Nabitaka Irene , Rujumba Joseph
Published: October 2023

Background:Sickle cell anaemia (SCA) can lead to complications in almost all body organs and the kidneys are frequently affected due to medullary infarction that occurs as a result of sickling events thus leading to hyposthenuria as well as renal tubular acidosis that in turn lead to enuresis. Globally the prevalence of enuresis in SCA ranges from 25% to 50.9% but the burden is not known in Uganda. We set out to determine the prevalence and factors associated with enuresis in SCA.
Methods: A cross-sectional study was conducted at the Mulago sickle cell clinic between December 2020 and January 2021. Consecutive enrolment of children aged 5-17 years confirmed to have SCA by hemoglobin electrophoresis was done. Information on prevalence and factors associated with enuresis was collected using structured questionnaires. Urinalysis and RFTs were done in those found with enuresis. Qualitative data regarding responses to enuresis was collected using in depth interviews with caregivers and children. Bivariate and Multivariate analysis using logistic regression models were utilized to determine the factors associated with enuresis. Qualitative data was analysed using content thematic approach.
Results: We enrolled 404 children aged 5- 17, half of whom (52.5%) were male. Median age (IQR) was 8(7-11). One in four children had enuresis (26.2%) (95%CI: 22.2-30.8). All had primary enuresis and 90% had monosymptomatic enuresis.
Age 5-7years aOR:2.03(95%CI:1.11-3.72) P value=0.022 and sibling history of bedwetting aOR:1.87(95%CI:1.08-3.24) P value=0.026 were significantly associated with enuresis while female gender aOR:0.58(95%CI:0.36-0.98) p value = 0.025 and fourth or higher birth order aOR:0.41(95%CI:0.22-0.78) P value= 0.007 were protective factors. Most caretakers had done nothing regarding bedwetting while others had used cultural practices and behavioral interventions but none had talked to a health worker about bedwetting and none had used enuresis alarms or medications.
Conclusion: The prevalence of enuresis in children with SCA was 26.2% which is high.
Enuresis was associated with family history of bedwetting and younger age of 5-7 years while female gender and fourth or higher birth order were protective factors. Few caregivers employed strategies that included cultural and behavioral interventions.
Geometric nonlinear effect on isolation performance for a scissor-like magnetorheological seat suspension
Authors: Li Xuan , Dong Xiaomin
Published: October 2023

Scissor-like seat suspensions (SL-SSs) with magnetorheological damper (MRD) has been commonly studied and applied successfully in vehicle vibration isolation. However, in most cases, modeling for scissor-like isolation structure is still inaccurate because of overlook on MRD’s layout. In this paper, effect of geometric nonlinearity by MRD’s installation position on the vibration isolation performance of a SL-SS is investigated. A dynamic parametric model of the SL-SS with six assembly types is derived considering geometric nonlinearity based on Lagrange equation. Then, the parameter analysis is performed to estimate magnetorheological damping function in SL-SS. The displacement transmissibility is solved via harmonic balance method, and its effectiveness is validated with numerical results. Finally, comparative study on displacement transmissibility for six assemble types is carried out, and metrics are introduced to access the isolation capabilities of the SL-SS. The results show that the system in type 3 has wider isolation band than other types. And the results also reveal that for type 1, 3 and 6, a minimum isolation frequency may realize, meanwhile, the maximum peak transmissibility also inevitably occurs; for type 5, increasing horizontal distance between installation points of MRD broadens isolation band, but leads to increment of peak transmissibility.
A novel method for random sequential high-capacity data hiding based on PVD and LSB
Authors: Wu Wanqing , Li Huili
Published: October 2023

In image information hiding, steganography capacity and image quality are the key indicators. Keeping the image intact with high embedding capacity is a major challenge in information hiding technology. This paper presents an adaptive block image steganography scheme based on pixel value difference (PVD) and least significant bit (LSB). The scheme achieves high capacity embedding while maintaining visually acceptable image quality, and the scheme is also resistant to regular and singular (RS) analysis and pixel difference histogram (PDH) analysis. The details are as follows: Firstly, the image is divided into 2$\times$2 non-overlapping blocks, and a random sequence of integers 1-4 is generated by chaotic mapping as the embedding order. The first pixel in the embedding order is selected as the reference pixel for LSB embedding. Secondly, the difference between the remaining pixels in the block and the reference pixel is calculated, and the embedded bit is determined according to the range where the difference is located. The mixed method of PVD and LSB is utilized to embed the remaining pixels. Finally, the embedded pixels are adjusted to ensure that the differences before and after embedding are in the same range. Experimental results show that the scheme can achieve an average embedding capacity of 930,312 bits, with an average embedding bits per pixel of 3.55 and a peak signal to noise ratio (PSNR) of 35.51 dB. The comparison with other hiding schemes shows that it has a larger hiding capacity than other schemes while maintaining good visual quality.
Certified coordinate selection for high-dimensional Bayesian inversion with Laplace prior
Authors: Flock Rafael , Dong Yiqiu , Uribe Felipe , Zahm Olivier
Published: October 2023

We consider high-dimensional Bayesian inverse problems with arbitrary likelihood and product-form Laplace prior for which we provide a certified approximation of the posterior density in the Hellinger distance. The approximate posterior density differs from the prior density only in a small number of relevant coordinates that contribute the most to the update from the prior to the posterior. We propose and analyze a gradient-based diagnostic to identify these relevant coordinates.

Although this diagnostic requires computing an expectation with respect to the posterior, we propose tractable methods for the classical case of a linear forward model with Gaussian likelihood. Our methods can be employed to estimate the diagnostic before solving the Bayesian inverse problem via, e.g., Markov chain Monte Carlo (MCMC) methods. After selecting the coordinates, the approximate posterior density can be efficiently inferred since most of its coordinates are only informed by the prior. Moreover, specialized MCMC methods, such as the pseudo-marginal MCMC algorithm, can be used to obtain less correlated samples when sampling the exact posterior density.

We show the applicability of our method using a 1D signal deblurring problem and a high-dimensional 2D super-resolution problem.
Hybrid polypropylene biocomposites reinforced with short man-made cellulose fibres and softwood flour - optimisation of properties using Response Surface Methodology
Authors: Franciszczak Piotr , Kovalovs Andrejs
Published: October 2023

Wood-plastic composites and composites reinforced with natural and man-made cellulose fibres are being extensively used in automotive and building industries. The main shortcoming of the former is their low impact resistance and brittleness. The relatively high cost of natural and cellulose fibres is the limitation of the latter. This research uses a hybrid combination of wood flour and short man-made cellulose fibres to develop PP composites for injection moulding that excel in mechanical characteristics and have low material cost. Both reinforcements are of wood origin. The synergistic hybrid effect of this combination of reinforcements helps to achieve their mechanical performance superior to that of WPCs at preserved low cost. The proposed Response Surface Methodology enables to calculate necessary weight fractions of two reinforcements to achieve desired mechanical properties like strength, Young’s modulus and impact resistance at adopted material cost.
Permutation invariant matrix statistics and computational language tasks
Authors: Accettulli Manuel Huber , Correia Adriana , Ramgoolam Sanjaye , Sadrzadeh Mehrnoosh
Published: October 2023

The Linguistic Matrix Theory (LMT) programme introduced by Kartsaklis, Ramgoolam and Sadrzadeh is an approach to the statistics of matrices generated and used in the fields of Computational Linguistics and Natural Language Processing. These matrices provide semantic representations for words and phrases of natural language. LMT is based on permutation invariant polynomial functions of matrices, which are regarded as the key observables encoding the significant statistics. In this paper, we generalize the previous results on the approximate Gaussianity of matrix distributions arising from a compositional distributional approach to natural language semantics. We also introduce two geometries of observable vectors for words, defined by exploiting the graph-theoretic basis for the permutation invariants and the statistical characteristics of the ensemble of matrices associated with the words. We describe successful applications of this unified framework to four tasks in semantic relation identification: synonym versus antonym distinction, a three-way classification of synonym pairs, antonym pairs and no-relation pairs, distinction between hypernym/hyponym pairs and co-hyponym pairs, and the distinction between a hypernym and co-hyponym within a pair.
Early Sertoli cell gene expression regulates pathogenesis in response to Ebola virus
Authors: Webb Andrew L. , Schindell Brayden G. , Soule Geoff , Siddik Abu B. , Abrenica Bernard , Memon Harram , Su Ruey-Chyi , Safronetz David , Kindrachuk Jason
Published: October 2023

Ebola virus (EBOV) persists and actively replicates in the reproductive tract of up to 50% of male disease survivors six month after infection1. Persistent EBOV infections are usually asymptomatic and can be transmitted sexually, but the host and viral factors that mediate these infections have not been characterized2,3. We assessed viral replication kinetics and host responses of mouse testicular Leydig and Sertoli cells infected with wild-type EBOV Makona (wtEBOV) and collected samples up to 28 days post-infection. While maximum EBOV viral load was similar in both cell types, viral transcription and replication was delayed in Sertoli cells compared to Leydig cells. Using RNAseq analysis, we found that Sertoli cells responded to wtEBOV infection more rapidly and robustly than did Leydig cells, and that early differential gene expression was primarily associated with membrane function and cell cycle activity. Experiments conducted with an EBOV virus-like particle model (vlpEBOV) indicated that differences in Leydig and Sertoli cell response occurred less than one-hour post-treatment, and evidence indicated that Sertoli cells limit early EBOV entry and/or transcription. Based on our analysis, we discuss how the roles played by Sertoli cells in immune privilege and spermatogenesis may affect their initial and continued response to EBOV infection and facilitate asymptomatic persistence.