bluuebunny/crossref_metadata_2025 huggingface dataset:
Advancing autism spectrum disorder diagnosis through ensemble learning
Authors: Nishat Tanveen , Juvvaladinne Trisha , Ambatipudi Durga Sravani
Published: May 2024

Autism Spectrum Disorder (ASD) diagnostics requires specialized clinical expertise, posing accessibility and affordability barriers for many. To widen the availability of precise screening, this paper examines ensemble machine learning models that combine multiple algorithms for improved accuracy and generalizability. Specifically, this paper compares the performance of K-Nearest Neighbor (KNN), Support Vector Machine (SVM), Naive Bayes, and a Voting Classifier that integrates Logistic Regression, Decision Trees, and KNN. The comparison was conducted on separate datasets of pediatric and adult ASD questionnaire responses. The ensemble model significantly outperforms individual techniques, achieving higher accuracy for both pediatrics and adults with balanced sensitivity and specificity maintained across groups, indicating the viability of accessible community-available screening to alleviate diagnostic bottlenecks. Before scale-up, further model optimization for interpretability and testing on more diverse multi-site data are warranted. Overall, findings demonstrate the feasibility of mobile distributed pre-screening systems leveraging optimized ensembles to predict ASD with high precision across ages, opening possibilities for explainable AI to lower costs and widen access compared to in-person evaluation.
Management of Patients with Heart Failure and Type 2 Diabetes Mellitus
Authors: De Luca Mariarosaria , Botta Amodio , Carbone Vincenzo , Carella Giovanni , Guardasole Vincenzo , Guarnaccia Franco , Maffettone Ada , Masi Stefano , Romano Geremia , Santoro Giosuè , Oliviero Ugo
Published: May 2024

The management of patients with cardiometabolic diseases is particularly complex and involves professionals from various disciplines. Cardiologists and diabetologists, the coordinators of this process, should cooperate in the implementation of a joint treatment and care plan. Based on these premises, a group formed by cardiologists from the Regional Association of Ambulatory Cardiologists (ARCA) and diabetologists from the Association of Diabetologists (AMD), operating in Campania, was set up to define the critical points and create shared diagnostic and therapeutic processes. We review the current evidence and gather the opinions of the group concerning the identification of patients at higher risk of diabetes and/or heart failure and the management of patients with known diagnosis of diabetes mellitus and heart failure.
Analysis of Programmed Nursing Cooperation During Gastrointestinal Endoscopic Mucosal Dissection
Authors: Shen Zhiping
Published: May 2024

Objective: To analyze the application value of programmed nursing combined with digestive endoscopic mucosal dissection. Methods: A total of 200 patients undergoing endoscopic mucosal dissection from February 2021 to February 2023 were included as samples. Randomized grouping was conducted, with Group A receiving programmed nursing cooperation and Group B receiving routine nursing. Nursing values were then compared. Result: Group A exhibited shorter operation and hospitalization times compared to Group B, with less intraoperative blood loss (P < 0.05). The SF-36 score for Group A was higher than that for Group B, and the postoperative complication rate in Group A was lower than in Group B (P < 0.05). Conclusion: The implementation of a programmed nursing coordination plan in gastrointestinal endoscopic submucosal dissection nursing proved effective in reducing endoscopic surgery bleeding volume, shortening the patient’s disease course, and enhancing the patient’s quality of life. This approach is efficient and feasible.
Comprehensive Analysis of the Correlation between Estrogen Levels, Homocysteine, and Lipid Profiles in Postmenopausal Women with Coronary Heart Disease
Authors: Dong Ying , Zhu Xiumei
Published: May 2024

Objective: To investigate the correlation between estrogen levels, blood homocysteine, and blood lipids in postmenopausal female patients with coronary heart disease. Methods: This study selected 50 postmenopausal female patients with coronary heart disease from Northeast Normal University Hospital (observation group). The data collection period extended from June 2021 to June 2023. Simultaneously, 50 healthy patients with no history of coronary heart disease were selected during the same period as the control group. Physical examinations were conducted for all participants. Estrogen levels, blood homocysteine, and blood lipid levels were tested in both groups. Results: Compared to the control group, the observation group exhibited higher levels of follicle-stimulating hormone (FSH), total cholesterol (TC), and homocysteine (Hcy), and lower levels of high-density lipoprotein cholesterol (HDL-C; P < 0.05). Pearson correlation analysis revealed a negative correlation between estradiol (E2) levels and changes in Hcy, TC, and low density lipoprotein cholesterol (LDL-C) levels (P < 0.01). Multivariate analysis indicated that E2 serves as a protective factor against coronary heart disease in postmenopausal women. Decreased E2 levels, LDL-C, and Hcy were identified as independent risk factors for coronary heart disease in women (P < 0.05). Conclusion: A declining trend in estrogen levels among postmenopausal women has implications for their blood lipid levels and is closely associated with the development of chronic complications of menopause.
Determining entrepreneurial knowledge and intentions of international students studying in Turkey
Authors: Karakaş A. , Ali M.A. , Çetin S.
Published: May 2024

Entrepreneurial knowledge and intention focus on understanding an individual’s interest in and abilities towards entrepreneurial activities. Another issue is the impact of cultural differences on entrepreneurial intention. The purpose of the study is to reveal the impact of entrepreneurship knowledge on entrepreneurial intention of international students receiving higher education in Turkey. We also examine whether there are differences in entrepreneurial knowledge and entrepreneurial intention according to gender, department, having an entrepreneurial business idea, receiving entrepreneurship education or not and monthly expenditure amount. The methodological basis of the study resides in the concept of entrepreneurial knowledge and planned behaviour theory. Among the research methods are frequency and regression analyses, parametric tests, convenience sampling method. A total of 380 students enrolled in 20 public and 5 private universities in Turkey in the 2021–2022 academic year participated in the survey and completed the questionnaire. Participants were reached through electronic and social media environments or face-to-face communication. The research results reveal that there are statistically significant differences between entrepreneurial knowledge and intention with educational status, entrepreneurial idea, department of study and the amount of monthly expenses. Furthermore, regression analysis showed that entrepreneurial knowledge and entrepreneurship education have a significant positive effect on students’ entrepreneurial intentions. The findings of this study provide valuable guidance for policymakers and curriculum preparers to understand international students’ entrepreneurial intentions and promote entrepreneurial intentions in universities.
Gender impact on consumer perception of packaging colour based on neuromarketing algorithms
Authors: Kalkova Natalia
Published: May 2024

The introduction of neuromarketing tools has created additional opportunities for deciphering consumer behaviour through studying neurophysiological responses to marketing incentives. The article aims to examine the effect of packaging colour on consumer behaviour when choosing cheese products. The principles of sensory marketing constitute the methodological framework of the study. It applies neurophysiological methods to investigate consumer reactions during visual examination of the packaging colour. Electroencephalogram (EEG) recordings and emotional responses identified by the Facial Action Coding System are used as empirical evidence. Vectors of emotional response were assessed using EmoDetect software. The research results show that the cheese packaging colour affects consumer choice, and its perception varies by gender and product group. According to EEG data analysis, the most intense emotional response in women was triggered by red cheese packaging, while blue packaging produced the least intense reaction. In men, it was black and white colours of boxes that induced the strongest and the weakest reaction, respectively. In women, a positive emotional response was recorded during visual examination of white and red cheese packaging, in men – of black ones. The most intense negative reactions were associated with blue and white packaging in women and men, respectively. Our study confirms that there are differences in emotional perception of the packaging colour between women and men, which should be considered by manufacturers to capture and keep consumer attention when marketing their products.
Gambaran Ekspresi Cluster of Differentiation 44 (CD44) Pada Meningothelial Meningioma di RSUD Provinsi Nusa Tenggara Barat
Authors: Santosa Hilda , Nini Cheryl , Sabariah Sabariah , Perdana Muhammad Astro
Published: May 2024

Meningiomas are mostly benign tumors that grow slowly and are very common compared to other intracranial tumors with the most frequent subtype being meningothelial meningioma. Cluster of differentiation 44 is a cell surface glycoprotein that has an important role in cellular adhesion, migration, angiogenesis, proliferation and inflammation. This study aims to examine the description of CD44 expression in meningothelial meningioma at West Nusa Tenggara Provincial Hospital. This study is a quantitative descriptive analysis research, sample 27 cases of meningothelial meningioma CD44 expression was evaluated by immunohistochemistry. Quantitative descriptive analysis to determine the percentage of the study sample. The results obtained were 19 (70.40%) age range 41-50 years. CD44 expression in meningothelial meningioma was found to be mild in 3 (11.10%), moderate expression in 5 (18.50%) and strong in 19 (70.40%). In conclusion, most of the percentages of tumor cells that were smeared were in the severe category (percentage value of more than 50 percent).
La poesía modernista de Valparaíso: Sobre las reuinas de Luis Hurtado López y el poeta como ángel de la historia
Authors: González Alfonso Felipe
Published: May 2024

Este artículo revalora una obra olvidada de la literatura de Valparaíso, destacando su singularidad e importancia: el libro Sobre las ruinas (1907) del poeta Luis Hurtado López (1877-1954). Para esto, se reconstruye su contexto social y cultural, vinculando el proceso de modernización de la ciudad con la orientación modernista-mundonovista de la obra y su temática del terremoto de 1906; a continuación, se ofrece una interpretación histórica y espacialmente situada. A través de cinco “entradas” el artículo describe y problematiza: 1) la inscripción del poeta en el modernismo chileno, 2) el campo cultural porteño de la obra, 3) sus particularidades estéticas e ideológicas, 4) la función del poeta que lleva implícita y, por último, 5) el cruce que efectúa entre la cuestión social y la catástrofe. Recurriendo a Walter Benjamin, se propone al respecto que la voz poética escenifica los desiguales efectos del terremoto para recomponer simbólicamente la comunidad de Valparaíso con un excedente crítico de sentido en torno al imaginario de progreso dominante.
Interacciones en la clase de literatura. ¿Construcciones dialógicas? Estudio de caso en establecimientos secundarios chilenos
Authors: Yuivar Carneiro Ana , Medina Morales Lorena Pía
Published: May 2024

Esta investigación tuvo como principales objetivos describir la naturaleza de las interacciones orales ocurridas en la clase de literatura en tres establecimientos educacionales chilenos de Tercero Medio (11vo grado) y, especialmente, describir las interacciones propiamente dialógicas, es decir, aquellas que propician la tensión entre diferentes voces o tomas de posición frente a las interpretaciones literarias abordadas en clase. Por lo anterior, se escogieron tres establecimientos de dependencia particular subvencionada que declararon promover el pensamiento crítico y el fomento lector en sus proyectos educativos. Los participantes del estudio fueron 3 docentes y 83 estudiantes. Se realizaron análisis estadísticos descriptivos y análisis dialógico del discurso sobre una muestra de 20 clases de literatura. Los resultados muestran que las interacciones ocurridas en estas aulas confirman el diagnóstico internacional y local, pues en ellas es el profesor quien domina la interacción y los aportes de los estudiantes son restringidos. Sin embargo, en uno de los casos, sí se ofrecieron oportunidades dialógicas en la fase de contextualización de la obra literaria, que implicaba abordar temas identitarios, no así en otros aspectos de la interpretación.
La vanguardia paradójica de Juan José Saer: señuelos y escamoteos
Authors: Longoni Torti Bruno
Published: May 2024

Desde la iconoclastia lectora de Sor Teresita y su pulsión iterativa disolvente del sentido textual a la combinación de lo invariante y lo fluido que Verde y Verdecito retoman del haikú japonés, Las nubes (1997) invierte el signo de la parodia aristofánica: si la comedia teatral griega se burla de las veleidades socráticas de los diletantes, Saer emprende una sutil exaltación de esos descartes del modelo civilizatorio occidental, expatriados de la República platónica. Esa caravana de autorretratos apócrifos vinculados a la vanguardia halla su mito de origen en esa curiosa mezcla de Juan L. Ortiz y Macedonio Fernández que encarna Washington Noriega en Glosa (1986), quintaesencia del escritor inorgánico y fragmentario, cuya inteligencia superior lo exime de los transitados caminos de la publicación y el reconocimiento. La narrativa de Juan José Saer se emplaza sobre esa paradoja: la del escritor al margen de las tendencias y el mercado que persigue, no obstante, la visibilidad.
Género, raza y clase en La sangre, el polvo, la nieve de Karina Pacheco Medrano
Authors: Susti Gonzales Alejandro
Published: May 2024

El artículo examina La sangre, el polvo, la nieve (2021), una novela de Karina Pacheco Medrano (Cusco, 1969), desde una perspectiva de género en el marco de la sociedad cusqueña de fines del siglo xix y la primera mitad del xx. En particular, se presta atención “al ejercicio del poder privado basado en la naturalización de la jerarquía de género y en la inferiorización de lo femenino por su identificación con lo doméstico” (Mannarelli 57), así como a los diversos roles que cumple la mujer en la sociedad (la “madresposa”, la maternidad, la conyugalidad y el erotismo). Para estudiar la estructura familiar del espacio doméstico se utiliza el concepto de la “gran casa” de Ariès y también se analiza de qué manera en esta se reproduce la herencia colonial de la sociedad peruana de la época (Quijano, Flores Galindo) y los roles que juegan la autoridad patriarcal y los personajes femeninos —madre e hija—, así como la reproducción de las jerarquías sociales y raciales en contraste al proyecto del indigenismo (De la Cadena), con el cual se identifican la protagonista Giralda Loayza y su esposo. Asimismo, se traza un paralelismo entre la novela y Aves sin nido (1889) de Clorinda Matto, reconociendo las diferencias en los proyectos de nación que ambas novelas proponen, así como el papel que juegan los núcleos familiares en ellas (Cornejo Polar). Finalmente, en términos de estrategias narrativas, se examinan las polarizaciones semánticas que propone la novela y la acercan a las novelas decimonónicas y al melodrama (Brooks).
Entre poesía y ciencia: Las colaboraciones de Josefina Dey en revista Zig-Zag (1908-1909)
Authors: Ramírez Errázuriz Verónica
Published: May 2024

Este trabajo se enmarca en el proceso de incorporación de las mujeres al campo profesional en Chile a inicios del siglo xx y, en específico, aborda el caso de la pedagoga Josefina Dey y su rol como colaboradora de revista Zig-Zag entre los años 1908 y 1909. Analizar su experiencia como poeta y su formación científica en función de su participación en el magazín chileno más relevante de la primera mitad del siglo xx, permite comprender, por una parte, la estrecha relación entre literatura y ciencia en la prensa del periodo y, por otra, la relevancia del talento literario como puerta de acceso para que las mujeres pudieran pronunciarse sobre temas científicos públicamente.
Humor en interacción: Apuntes para su estudio sociopragmático y geolectal
Authors: Cestero Mancera Ana M. , Moreno Martín de Nicolás Nicolás
Published: May 2024

El estudio del humor verbal lleva recorrido ya un largo camino, lo que ha propiciado que, en el siglo xxi, sea atendido, con perspectivas multidisciplinares, como un fenómeno pragmático de gran interés. Hace ya más de una década que se extendió la investigación sobre el humor a contextos y géneros no puramente humorísticos, desarrollándose el acercamiento que se conoce como humor interactivo (Chovanec y Tsakona, 2018). El grupo GRIALE ha sido pionero en analizar el humor conversacional en español en este marco y ha ofrecido un modelo analítico que permite acercarse a diversas dimensiones de la estrategia pragmático-discursiva, partiendo del proceso de producción, pero sin olvidar el de recepción (Ruiz Gurillo, 2012, 2014, 2019, 2021, 2022a, 2022b; Alvarado Ortega, 2012, 2014, 2017, 2022). Tomando los hallazgos y las propuestas de GRIALE como base, se ha iniciado una investigación con el objetivo de conocer el uso y funcionamiento del humor en interacciones en registro medio de lengua, así como de documentar patrones sociopragmáticos y geolectales en su empleo. En este artículo, se presentan los planteamientos teóricos y metodológicos básicos para abordar el estudio coordinado del humor en conversaciones semidirigidas, interacciones en registro semiformal, y se adelantan resultados de los primeros análisis realizados. Los datos revelan que quienes más recurren a esta estrategia son las mujeres y que el mecanismo más rentable en el tipo de actividad es la incongruencia, así como que el marcador de humor habitual es la risa y el indicador más frecuente, el empleo de unidades fraseológicas.
Radioterapia Intraoperatória: um relato do processo de comissionamento e análise de risco
Authors: Aparecida Forner Lais , Reis dos Santos de Jesus Gabriela , Piai Groppo Daniela , Henrique Bonfim Cardoso Pedro
Published: May 2024

A radioterapia intraoperatória é uma modalidade na qual entrega-se uma alta dose em uma única fração ao leito tumoral. Este trabalho teve como objetivo a implementação dessa técnica por meio de aquisição e análise de parâmetros físicos e dosimétricos e análise de risco, utilizando a ferramenta FMEA. Os parâmetros analisados foram: PDP, fator rendimento, dose na superfície externa do aplicador, perfil do feixe, transmissão e fator backscatter dos protetores. O fator rendimento apresentou um aumento com o aumento da energia e do diâmetro do aplicador. A dose na superfície externa do aplicador se torna mais significativa com aumento da energia. A caracterização dos fatores de transmissão e backscatter dos discos protetores evidenciaram suas adequações. Quanto à ferramenta de análise de risco FMEA, obteve-se o valor máximo de NPR de 180, com os processos de maior prioridade ocorrendo durante o procedimento cirúrgico. A modalidade de radioterapia intraoperatória foi implementada com êxito, e o FMEA mostrou-se uma ferramenta útil para auxiliar na criação de um programa de garantia da qualidade afim de evitar falhas.
The Mystical Form: Spirituality, Materialities, and Affectivity in Colombian Popular Politics = La Forma Mística : Espiritualidad, Materialidades y Afectividad en La política Popular Colombiana
Authors: Garzón Maite Yie
Published: May 2024

Abstract: This article studies the role of spiritual ceremonies known as "mystics" in the popular politics of grassroots organizations in Colombia. Based on an ethnographic approach to the Popular and Spiritual Inauguration of Gustavo Petro and Francia Márquez, I argue that the mystic constitutes an experimental and popular form of political (re)composition that involves the institution, activation, and/or reorientation of affective ties between bodies. I also propose that this ceremony constitutes a form of political articulation that works with and produces difference without the promise of a synthesis, the success of which depends on being flexible enough to allow the entry within popular and institutional politics of historically marginalized aesthetic, spiritual, and political sensibilities linked to different horizons of struggle. In the end, the article reflects on the place of bodies, materiality, and aesthetics in the processes of political (re)composition. Resumen: El artículo aborda el papel de las ceremonias espirituales conocidas como "místicas" en la política popular de organizaciones de base en Colombia. A partir de una aproximación etnográfica a la Posesión Popular y Espiritual de Gustavo Petro y Francia Márquez, sostengo que la mística constituye una forma experimental y popular de (re)composición política que pasa por la institución, activación y/o reorientación de vínculos afectivos entre los cuerpos. Planteo, así mismo, que la mística constituye una forma de articulación política que trabaja con y produce la diferencia sin la promesa de una síntesis, cuyo éxito depende de ser lo suficientemente flexible para permitir la entrada en la política popular e institucional de sensibilidades estéticas, espirituales y políticas históricamente marginadas, ligadas a diferentes horizontes de lucha. Al final, el artículo reflexiona sobre el lugar de los cuerpos, la materialidad y la estética en los procesos de (re)composición política.
THE EFFECT OF (DMAA), DIMETHYLACETAMIDE ON THE BLOOD OF THE COWS IN VITRO
Authors: H. AL-Attia H. , M. Jasim Y.
Published: May 2024

Dimethylacetamide (DMMA) is used as a solvent for drug preparations, DMAA and its metabolites
Monome thy lacetamide (MMAA) and acetamide (AA) cause hemolysis in concentrations above 100
(DMAA), 44 (MMAA) and 40 (AA) mg/ml blood respectively. The effects are double to three times
stronger than after distilled water.
Dimethylation in the animal body after treatment is followed by an increase of the hemolytic activity.
Concentrations after therapeutic use in vivo are as high as the concentration in vitro in hemolysis activity.
RSCHERICHIA COLI IN BROILER CHICKENS ‎ I- SEROLOGY AND ANTIBIOTIC SENSITIVITY
Authors: Hyder Al-Safi Hazim , G. Abdul Ghani Zeki , A. Al-Attar Majed
Published: May 2024

A study was dane on 300 cases of Colibacillosis in broiler chickens collected from poultry farms in Baghdad. Escherichia coli was isolated from all cases from heart blood. The highest incidence (45%) of the disease was noticed among the 3-4 weeks old chickens. The antibiotic sensitivity test revealed that all isolates were resistant to  Chloramphenical, Tetracycline,Lincomycin and Erythromycin. Ninty five percent of the isolates were resistant to Sulfa Trimethoprim mixture and 40% to Ampicillin. Serotyping of some of the isolates  showed that the serotypes 01, 02 and 078 were the most prevalent types; other serotypes were also identified especially 035, 036, 088 and 018.
EFFECT OF MIXING COLIGEN AND HEMORRHAGIC SEPTICARMIA VACCINES ON THE IMMUNE RESPONSE IN ANIMALS
Authors: A. Khalifa Khalifa , J. Fiall Tarik , A. Al-Jubouri Kifah
Published: May 2024

This study was done to evaluste the possible effect of mixing coligen vaccine prepared from E£. coli with hemorrhagic septicaemia vaccine prepared from P. multocida on the development of immmity. Awwasi sheep were used as experimental animals. A slight increase in the mean antibody titers in the animal group vaccinated with the mixed vaccine compared to the groups received each vaccine separately was noticed. Challenge experiment showed that protection against heterologous organiams by using homologous vaccine was low (12.5%) in comparison with the group received homologous vaccine (protection 87.5%). No detectable reaction tms noticed with the antisera and heterologous antigens.
ECONOMIC NUTRITIONAL REQUIREMENTS FOR IRAQI AWASSI SHEEP
Authors: S.A. Al-Tekrity S. , K. Al-Murani‎ W.
Published: May 2024

This study was performed to define the best nutritional level expressed according to Morrison feeding standard 80%, 100% and 120% of these standards were given to three groups of awassi lumbs. Results indicated the superiority of the 120% level in reaching the slaagter weight (45 Kg).The experiment also reflected that digestibility in goats is better than that in sheep.
MORPHOLOGICAL HI8STOPATHOLOGICAL CHANGES IN SOME LIVER DISEASES IN CATTLE
Authors: G. Habasha F. , Al- Jeddah M. , M. Al-Darraji‎ A.
Published: May 2024

Liver biopsies were taken from (89) cattle slaughtered at modern Baghdad abattoir. Macroscopic examination of livers showed that (28.11%) of cases were infected with chronic fascioliasis, while (1.12%) of livers showed acute fascioliasis and (2.24%) of livers showed chronic fascioliasis with hydatidosis. Hydatid cysts were present in (6.74%) of inspected livers, telangiectasis of the livers found in (3.37%) of cases, focal hepatic necrosis (Saw dust) was observed in (19.1%), liver abscesses constituted (1.12%) and (38.2%) of livers had no significant gross lesions. The diagnosis of liver diseases in cattle using liver biopsy technique was more successful when the lesion was extensively diffuse in the liver.
THE PREVALENCE AND RELATION OF OVINE PROGRESSIVE PNEUMONIA TO PASTEURELLA HAEMOLYTICA IN TWO FLOCKS OF SHEEP
Authors: Badri Abboud Hayder
Published: May 2024

The incidence of ovine progressive pneumonia (OPP), and its relation to Pasteurella haemolytica in two naturally infected flocks of sheep of different ages was studied. The Ager Gel Immunodiffusion test was used for testing for OPP. Nasal Swabs were taken for the isolation of P. haemolytica. Four ewes were necropsied, anu both gross and histopathological examinations were done. A few seronegative sheep sero-converted and the seropositive sheep remained positive. Seropositive sheep did not develop clinical illness or lesions of the disease at Lambing (stress factor) necropsy. to predisposes infection with OPP. Infection with OPP predisposes sheep for secondary bacterial infection with P. haemolytica.
EFFECT OF THREE ANTIBIOTICS ON BYPERIMENTAL INFECTION OF BROILERS WITH MYCOPLASMA GALLISEPTICUM
Authors: Abed AH. , A. Alkhayyat A. , N. Al-‎ Shammary A.
Published: May 2024

Four groups of 36 days old chicks were infected experimentally with mycoplasma ‎gallisepticun suspension while a control group was injected with nutrient broth and ‎another control group was left uninfected  Thtee of the infected groups were treated with ‎either Tylosin Spiramycin or  lincomycin.‎Parameters of airsacculitis score, and weight gain food conversion were used to evaluate ‎the treatment.‎Also, the residues of tylosin in blood plasm nd muscles and the level of spiramycin in blood ‎plasma was estimated by a microbiological assay.‎    The results showed significant differences between infected and non-infected ‎groups with all parameters used Treatment with tylosin and apramycin improved weight ‎gain and increased food consumption but did not reduce airsacculitis score. Tylosin level in ‎plasma was 75 μg/ml at termination of treatment and 0.16 μg/ml ‎ after 3 days, While ‎measurable level was seen after 7 days. With spiramycin the corresponding levele were ‎‎0.43, 0.20, and 0.18 μg/ml ‎ respectively. The level of tylosin in guacles was 0.14 μg/mg ‎
Falls prevention and frailty management in community-living older adults: Current challenges in community practices
Authors: Xu TianMa
Published: May 2024

This paper addresses the current challenges associated with implementing falls prevention and frailty management programs for older adults in the community setting. Falls and frailty are closely linked to various ageing-related health issues. While extensive research has been conducted on falls and frailty in older adults, these areas have often been studied in isolation from each other over the past few decades. Although evidence-based fall prevention and frailty management programs have been well-established in well-developed countries, barriers to implementing condition-specific interventions, such as manpower shortages, space constraints, and lack of public awareness and funding, still exist. Additionally, some evidence-based programs have shown limited clinical effectiveness when implemented in overseas contexts. Effective programs that target both fall prevention and frailty management remain limited. Currently, there’s a growing trend of adopting a combined approach in designing and implementing programs that address both falls and frailty in the older adult population. Encouraging future research studies in this area is crucial to support the translation of evidence into practice for fall prevention and frailty management.
Bioinformatics analysis of clinical isolates of Escherichia coli from Nigeria and other countries for quinolone and fluoroquinolone resistance
Authors: Udochi A. Ugo  , Ebele Onuigbo  , Iniekong Philip Udoh  , Miriam Goodness Udochukwu Nwaneri  , Mohamed Alawami  , Gonesh Chandra Saha  , Chukwunonso Mabel Eduzor  , Samson O. Aisida  , Lilian Ngozi Chukwuma  , Nosa Aima Airenobuwa
Published: May 2024

Quinolones were the drugs of choice for the treatment of bacterial infections, especially, infections caused by Gram negative bacteria. Unfortunately, these drugs have been resisted by the microbial agents including Escherichia coli, known to be the leading cause of Urinary Tract Infection (UTI) globally. This study therefore was aimed at detecting all the genes involved in Quinolone resistance by the E. coli pathogen isolated from Nigeria and from other geographical regions, using robust techniques. Twenty-three sequence data files of Escherichia coli from various countries of the world were retrieved from the National Centre for biotechnology Information (NCBI) database and sent for genome assembly for processing of the short reads into long reads. The outcome was config. fasta files which were comprehensively annotated and characterized for genetic functions and mechanisms. A total of 208 antibiotic resistance genes were detected, out of which 27(13.0%) were linked to quinolone resistance and 14(6.7%) to multi- drug resistance. The result of this study significantly implicated many genes in quinolone resistance; notably were the efflux pump genes and their high percentage abundance. We recommend in-depth study of the genes for their expression capabilities, also the structure and features of the efflux pump genes to enable proper redesigning of drugs by integrating anti efflux pump substances that will selectively prevent the expression of the genes for antibiotic resistance, without any harm to the host, or that can destabilize the positive regulation of the operon for antibiotic resistance.
Risk Assessment Grid, Priority Gaps and Action Plans of Infection Prevention and Control at Benghazi Medical Center.
Authors: Abdelmetalab Fergani Tarhuni  , Wafaa Idris Labaidi  , Nour-alhouda Mohammad Labaidi  , Isra Adam Alagori  , Hebatullah Elzawaam Ibrahim  , Ali Ateia Elmabsout
Published: May 2024

Identifying what could cause injury or illness and taking actions to eliminate the hazard and if it’s possible to control the risk is the main job of infection prevention and control team. This research attempts to investigate the risk and the priority gaps and control at Benghazi Medical Center. The methodology used here is using a check list from WHO organization and go through each point in the list while visiting different department at Benghazi Medical Center, aiming to evaluate and assist each department gaps in infection prevention and control (IPC) for different aspects like the infection prevention program, guidelines, education and training, surveillance, monitoring/ audit of IPC practices and feedback, workload staffing and bed occupancy, built environment, material and equipment for IPC at the facility level. Each of the previous points will be dealt with to highlight its results. After going through the research and the checklist the results found that the overall median score of IPC level is 225 which makes the hospital fall under the category of basic. To conclude, this research, has found gaps in monitoring hand hygiene, intravascular catheter insertion and/or care, wound dressing change, transmission-based precautions and isolation to prevent the spread of multidrug resistant organisms, consumption and usage of alcoholic-based handrub or soap. Consumption and usage of antimicrobial agents. significant of the study. There are more than 100 million patients every year around the world infected with health care associated infection which is due to their long stay in health care facilities that leads to a high morbidity and mortality rate.
Efficacy of antioxidants in the management of psoriasis: A case control study
Authors: Mohammod Abu Hena Chowdhury  , Afroza Jesmin  , Samiul Huq  , Abdul Latif Khan  , Anzirun Nahar Asma  , Touhida Noor
Published: May 2024

Introduction: Psoriasis is a chronic, immune-mediated inflammatory dermatosis. The pathophysiology of the disease is still incompletely elucidated and multiple factors are said to be involved in its initiation and perpetuation, e.g., stressors, genetic factors, environmental factors. In the last decade, a new theory is trying to explain the pathophysiology of this disease by looking at the role played by oxidative stress and chronic inflammation in the initiation of keratinocyte proliferation and differentiation. Keeping in consideration the increased oxidative stress in the patients of psoriasis, the anti-oxidant drugs can form an important part of the therapeutic ladder of psoriasis. Materials and Methods: The aim of this study was to measure the possible role of oxidative stress in psoriasis patient by measuring SOD level and comparing it with normal individuals and administer antioxidants supplements to the patients group to see the efficacy. It was a Case- Control study (1st part) and Clinical Trial without control group (2nd part). The study was carried out in Psoriasis awareness Club from June 2023 to December 2023. Purposive sampling done who fulfill the inclusion & exclusion criteria. 23 patients with psoriasis and 23 age and sex matched control subjects were recruited for this study. Clinical severity of the disease was determined by PASI score. All patients and control subjects were examined for plasma SOD level. 23 psoriatic patients were given antioxidant therapy in the form of once daily tablet for 30 days. PASI score, DLQI and SOD (Superoxide dismutase) level were measured before therapy (day 0) and after therapy (day 30) in patients group. Statistical analysis and Results: Data were expressed as mean ± standard deviation (SD) for quantitative variables and numbers. For comparison of two means (t test) and (ANOVA "F") test were used for several means. Chi-square (χ2 ) or fisher exact test were used when appropriate, (P<0.05) was considered statistically significant. The mean age of the patients and control subjects were 37.64 (±5.89) and 33.6 (11.02) years, respectively. The mean duration of the disease was 12.43 (±8) years. No significant difference was observed between SOD level of psoriatic patients & controls. No significant correlations of SOD level with severity of psoriasis and duration of disease were found. We observed no statistically significant difference in PASI and DLQI scores before and after antioxidant therapy but there was significant increase in the level of SOD after treatment. Conclusion: It is indisputable that antioxidant supplementation can reduce the overall morbidity, enhance the prognosis of psoriasis. Notably, in most cases, antioxidants alone are not able to induce significant clinical changes in the aspect and/or course of the disease, except perhaps in mild forms. They must be used in conjunction with standard pharmacological treatments to achieve measurable results.
Advanced risk management models for supply chain finance
Authors: Uzoma Okwudili Nnaji  , Lucky Bamidele Benjamin  , Nsisong Louis Eyo-Udo  , Emmanuel Augustine Etukudoh
Published: May 2024

This review paper delves into the transformative potential of advanced risk management models in enhancing the resilience and efficiency of supply chain finance (SCF). By examining the application and development of Artificial Intelligence (AI), Machine Learning (ML), Big Data analytics, and blockchain technology, the paper highlights their role in transitioning from traditional reactive strategies to proactive and predictive risk management approaches. Despite the promising advantages, the paper also addresses the significant implementation challenges, model limitations, and regulatory and ethical considerations accompanying these technological advancements. Recommendations for effective deployment and areas for future research, particularly in overcoming existing hurdles and exploring emerging technologies, are also discussed. This comprehensive analysis aims to guide academics, industry professionals, and policymakers in harnessing advanced risk management models for a more robust SCF ecosystem.
Pelatihan Investasi Saham Bagi Generasi Millenial Di Pasar Kerkap Bengkulu Utara
Authors: Indah Oktari Wijayanti  , Halimatusyadiah Halimatusyadiah  , Nikmah Nikmah
Published: May 2024

This investment in real wealth must be invested in the long term to make a profit. However, investments in the capital market that are invested in the short term will provide benefits. This phenomenon is an opportunity to provide education to the public in increasing knowledge about investing in the capital market, especially stocks. Shares are certificates that show proof of ownership of a company (Tandelilin; 2010). This is very important because basic investment knowledge will be able to prevent people from entering into irrational investment practices and illegal investments. Therefore, an educational program on capital market investment, especially stocks, is needed. One of the educational programs is capital market training targeting the public as potential investors. This program is in collaboration with the Indonesian Stock Exchange Investment Gallery (GI-BEI) Faculty of Economics and Business, University of Bengkulu. The community in Pasar Kerkap Bengkulu Utara is one of the people who are interested in deepening their knowledge of investing in the capital market, especially stock products. With this capital market training, it is hoped that the community will become active investors in the capital market using technical analysis, so as to improve the welfare of the community.
ARTROSCOPIA ANTERIOR E POSTERIOR DO TORNOZELO EM DECÚBITO VENTRAL: DESCRIÇÃO DE TÉCNICA CIRÚRGICA.
Authors: Ambrosio Gustavo Henrique Carillo , Lemos André Vitor Kerber Cavalcante , Pereira Vinicius Felipe , Nery Caio Augusto Souza , Mansur Nacime Salomão Barbachan
Published: May 2024

A utilização da artroscopia na cirurgia de tornozelo apresenta uma série de vantagens em comparação a cirurgia aberta e pode ser realizada por via anterior ou posterior. As doenças localizadas na região anterior e posterior do tornozelo podem coexistir e demandar a combinação das técnicas artroscópicas citadas. O objetivo deste estudo é descrever a técnica artroscópica para acesso anterior e posterior do tornozelo para o tratamento da instabilidade lateral e impacto posterior do tornozelo, mantendo o paciente em decúbito ventral.
Avaliação clínico-imaginológica dos pacientes submetidos a osteossíntese de fraturas do tornozelo com haste de fíbula
Authors: Gomes Rogerio de Andrade , Gomes Anderson Humberto , Magalhães João Murilo Brandão , Vieira Wagner da Fonseca , Pádua Bruno Jannotti , Fortes Gustavo Heringer Cezar , Milhomem Paulo Arthur Mendes , Dias Paulo Feliciano Sarquis
Published: May 2024

Objetivo: Realizar uma avaliação clínica e imaginológica de pacientes com fraturas do tornozelo submetidos a osteossíntese com haste bloqueada, analisando o encurtamento da fíbula e redução tíbio-talar através de parâmetros de imagem bem estabelecidos na literatura.
Métodos: Foram selecionados 25 pacientes operados pela técnica de haste intramedular bloqueada de fíbula, submetidos a cirurgia entre abril de 2018 e dezembro de 2022. Os pacientes tinham idade acima de 55 anos, com risco aumentado para complicações de cicatrização. Para avaliação clínica foram usados: escore AOFAS e escala visual analógica. Os parâmetros de imagem utilizados foram o ângulo talocrural, o espaço claro medial e a linha tibiofibular.
Resultados: Foi avaliado escore AOFAS com média de 83,48 (± 15,34), com mínimo de 40 e máximo de 98 pontos. Na escala visual analógica de dor, a média foi 2,56 pontos (± 2,50), com mínimo de 0 e máximo de 8. Na linha anterior tibiofibular, a diferença entre a média e o valor de referência (2 mm) foi de 0,38 mm. Sobre o espaço claro medial, 100% apresentou valores dentro da referência (até 4 mm). Na análise do ângulo talocrural, a média das diferenças obtidas entre os valores de cada paciente e a referência se situaram dentro dos valores normais.
Conclusão: A osteossíntese de fraturas do tornozelo com haste intramedular bloqueada é uma excelente alternativa nos pacientes idosos e com risco aumentado para complicações, conduzindo a bons resultados funcionais em seguimento de médio prazo, apesar de não mostrar uma redução satisfatória de redução da sindesmose na maioria dos casos
Use of Figueiredo’s technique for treating extensive infected skin lesions – a case report
Authors: Gomes André Cipriano Saraiva , Mesquita Isanio Vasconcelos , Leitão Júnior Péricles Saraiva , Oliveira Lucas Kaled Milhomem Malaquias de , Dias Neto Vicente de Sousa , Silva Filipe Henrique Soares Silva
Published: May 2024

Demonstrate that a low-complexity surgical technique can effectively solve problems of extensive skin lesions in cities where microsurgical techniques are not available. We present a 59-year-old male patient with diabetes mellitus and an extensive and infected lesion in his right ankle region, suggestive of a diabetic foot. Urgent surgical treatment was performed with debridement of the devitalized tissues, drainage of a large amount of purulent secretion, and exhaustive washing with 0.9% saline solution. After a new debridement, abundant washing with 0.9% saline solution and coverage of the extensive bloody area with a polypropylene prosthesis were performed. He remained under outpatient follow-up, and subsequently, twice, new cleanings were performed, and a small diameter mesh was applied due to the good evolution of healing. A good range of motion was maintained in the right ankle and foot, with the medial wound completely healed, leaving only a small area of the lateral wound to complete the healing process. Figueiredo’s technique, described in 2017 for fingertip lesions, uses a flexible thermoplastic polymer, which can be obtained from a small portion of silicone from a saline bag, to form a semi-occlusive dressing that allows the drainage of secretions and provides a favorable environment and temperature for healing. The exact limits of this technique are not yet well established, but the practice has shown excellent results in larger lesions. Figueiredo’s technique is a simple, low-cost, and effective option for treating extensive infected skin lesions. Level of Evidence IV; Therapeutic studies; Case Report.
CONFIABILIDADE INTER E INTRAROBSERVADOR DAS MEDIDAS DO ALINHAMENTO SAGITAL DO PRIMEIRO METATARSO.
Authors: Romanholi Pedro Bragato , Gobbo Daiana Kerry Picanço , Said Thaís Buchaim , Silva Daniel Araújo , Rosemberg Dov Lagus , Mann Tânia Szejnfeld , Freitas Cláudia Diniz , Rosa Felipe Daniel Plata , Nishikawa Danilo Ryuko Cândido
Published: May 2024

Introdução: as medidas radiográficas são utilizadas para indicar e programar procedimentos ortopédicos no antepé, bem como para seguimento pós-operatório. Com isso, muitas vezes é necessário avaliar se houve alteração no alinhamento sagital do primeiro metatarso (1M). O objetivo desse estudo foi analisar a confiabilidade inter e intraobservador das medidas angulares utilizadas para avaliação do alinhamento sagital do 1M. Secundariamente, avaliar se o tipo anatômico do pé interfere na confiabilidade das medições.
Métodos: as medidas angulares utilizadas foram todas aquelas encontradas na literatura, tais como: ângulo de declinação do 1M (AD1M), ângulo plantar distal do 1M (APD1M), ângulo dorsal proximal do 1M (ADP1M), ângulo intermetatarsal lateral (AIML), e o ângulo descrito por Day. Para avaliação da confiabilidade interobservador foi utilizado o Coeficiente de Correlação Intraclasse (CCI) e para avaliação da confiabilidade intraobservador, o Coeficiente de Correlação de Concordância de Lin (CCCL).
Resultados: dentre todas as medidas obtidas, AD1M foi o que apresentou os maiores valores de CCI e CCCL nas 40 radiografias avaliadas, independentemente do tipo anatômico do pé.
Conclusão: com os resultados observados, podemos estimar que o AD1M parece representar uma ferramenta radiográfica adequada para mensuração do alinhamento sagital do 1M, quando avaliada pelo CCI e CCCL.
Tratamento não cirúrgico da entorse de tornozelo: pesquisa das condutas dos ortopedistas de Minas Gerais
Authors: Baumfeld Tiago Soares , Lopes Tainne Gomes , Souza Gustavo Henrique Dornela de , Temponi Eduardo Frois , Santos Lucas do Amaral , Nunes Gustavo Araujo , Aquino Cecília Ferreira , Campos Túlio
Published: May 2024

Introdução: A entorse de tornozelo é uma lesão comum na população geral e, principalmente, em atletas. O diagnóstico e tratamento adequados permitem o retorno precoce às atividades habituais, evitando recorrência, instabilidade crônica e artrose pós-traumática. O objetivo deste trabalho é avaliar a abordagem diagnóstica e terapêutica desta lesão por ortopedistas do estado de Minas Gerais. Métodos: Esse trabalho foi conduzido pela Comissão Científica da Sociedade Brasileira de Ortopedia e Traumatologia-SBOT/MG em 2023. Foi criado um questionário na plataforma Google Forms com perguntas sobre a abordagem não cirúrgica da entorse de tornozelo. Esse questionário foi distribuído por e-mail e WhatsApp aos membros titulares da SBOT de Minas Gerais. Resultados: 116 ortopedistas responderam ao questionário, sendo 27,6% especialistas em pé e tornozelo. A maioria trabalha em Belo Horizonte e realiza entre 10 e 30 atendimentos relacionados à entorse de tornozelo por mês. A maior parte dos profissionais solicita radiografias e prescreve anti-inflamatórios. A maior divergência de respostas ocorreu quanto ao uso de imobilização. O encaminhamento para tratamento fisioterapêutico variou com o grau da lesão. Discussão: Os dados coletados apontam que a abordagem inicial nas entorses de tornozelo é heterogênea, porém a maioria utiliza protocolos de reabilitação convencionais, apesar da abordagem funcional ser preconizada pela literatura científica. Conclusão: Em Minas Gerais, o protocolo convencional de imobilização e reabilitação é utilizado com maior frequência.