bluuebunny/crossref_metadata_2025 huggingface dataset:
La question de la faute inassurable dans les relations d’assurance
Authors: Serwach Małgorzata
Published: September 2021

La réponse à la question si l’assureur peut prendre en charge les conséquences du comportement fautif (non-intentionnel et intentionnel) de l’assuré varie selon ce que le contrat d’assurance relève du domaine de l’assurance de biens ou celle de personnes. Il ne pourrait pas en être autrement, étant donné les rationes legis différentes et les objectifs dissemblables que ces deux types d’assurances ont à atteindre.
La responsabilité de la société envers les actionnaires minoritaires
Authors: Lemonnier Mariola
Published: September 2021

Les actionnaires minoritaires sont considérés comme actionnaires, lesquels par le fait du faible apport dans la société ne disposent pas de beaucoup d’impact sur le fonctionnement de l’entreprise. En droit polonais, il n’y a pas de définition légale de la notion de minorités. L’art. 418 du Code des sociétés commerciales ne peut pas être la base de la définition générale car l’acquisition obligatoire des actionnaires minoritaires n’est pas le seul attribut des actions de ce type. Les actionnaires peuvent être divisés en actionnaires majoritaires, minoritaires et petits actionnaires. Le concept d’actionnaire minoritaire est particulièrement nécessaire pour savoir qui le législateur protège comme la partie la plus faible dans les relations. Selon le critère de l’impact sur les actionnaires de la société – on peut distinguer l’actionnariat plein par l’effet contraignant sur la société, ensuite la majorité, la minorité, et l’actionnariat minimal (petit). Un autre classement indique la minorité d’actions de blocage, actions de la majorité qualifiée et actions de la société dominante.
La responsabilité de l’employeur sur le fondement du Code civil en cas de licenciement abusif
Authors: Makowski Dariusz
Published: September 2021

D’après l’interprétation constante des dispositions citées ci-dessus, le Code du travail réglemente les prestations dues au salarié abusivement licencié de façon autonome et intégrale. La limitation du montant de ces prestations est le plus souvent justifiée par la spécificité de la relation d’emploi et la nécessité d’équilibrer les intérêts mutuels. On admet que la réalisation du droit de réparation du préjudice dont un salarié dispose devrait être dans ce cas relativement simple et fiable. Il en résulte que le préjudice causé par le licenciement irrégulier est réparé en dépassant parfois le montant de ce préjudice mais parfois il n’est réparé que partiellement. Dans le cas de la rémunération pour la période sans emploi, on ajoute que l’absence du montant de cette prestation pourrait affaiblir la motivation du salarié à rechercher un nouvel emploi.
Responsabilité civile complémentaire de l’employeur en cas d’accident du travail
Authors: Kurzynoga Małgorzata
Published: September 2021

L'article se résume à la question suivante : un employé peut-il engager la responsabilité de l'employeur pour obtenir des avantages supplémentaires ? Deux opinions différentes sont présentées sur cette question.
SARS-CoV-2 y cambios en la vida de los estudiantes de Economía Agrícola y Agronegocios
Authors: Naranjo Retana Amanda María , Rodríguez Rodríguez Alejandra María , González Sánchez Eylin , Redondo Angulo Fauricio Josue , Sánchez Leon Stephanie de los Ángeles , Cortés Arias Ericka María , Rivas Briceño Abril
Published: September 2021

El objetivo de este artículo es identificar y analizar los cambios en la vida cotidiana, laboral y académica que han percibido los y las estudiantes de Economía Agrícola y Agronegocios de la Universidad de Costa Rica (UCR) pertenecientes a la sede Rodrigo Facio, sede del Sur y el recinto de Guápiles, producto de la adopción de la modalidad virtual en su proceso de aprendizaje. Se seleccionó una muestra de estudiantes activos y se les aplicó una encuesta online a través de la herramienta de Google Forms. A raíz de la virtualidad los estudiantes percibieron afectación en su salud física y mental, así como se evidenció que persisten las brechas que limitan la inclusividad de los estudiantes para llevar a cabo sus estudios de manera virtual.
Valores do Trabalho para Estudantes de Stricto Sensu em Contabilidade das Gerações Y e Z
Authors: Sousa Rayane Camila da Silva , Colauto Romualdo Douglas
Published: September 2021

O estudo analisa os valores do trabalho interpretados como significativos para estudantes das gerações Y e Z do stricto sensu em contabilidade. Participaram da pesquisa 337 estudantes de pós-graduação stricto sensu da área de Contabilidade, sendo 246 da geração Y e 91 da geração Z. O estudo utiliza a Escala Revisada de Valores Relativos ao Trabalho, Análise Descritiva e Análise Fatorial Exploratória. Os valores do trabalho considerados mais importantes foram aqueles sobre estabilidade no trabalho e independência financeira que compuseram o fator Segurança; os valores menos importantes foram aqueles relacionados ao status, soberania e prestígio que compuseram o fator Poder. Os achados ajudam os gestores a conhecerem as características das novas gerações e no ambiente acadêmico possibilita repensar práticas educativas
EFFECT OF ADJUVANT PREPARATIONS ON THE EXPRESSION OF ANALGETIC ACTIVITY OF MORPHIN IN SOMATOGENIC PAIN
Authors: Semenova Yu. V , Eliseeva N. V , Spasov A. A
Published: September 2021

Combination of traditional opioid with coanalgesics is recommended to reduce the dose of analgesics and the side effects as well as the relief of different pain severity. In this study was evaluated the effectiveness of different adjuvant drugs: haloperidol (0,45 mg/kg), metoclopramide (5 mg/kg), gabapentin (90 mg/kg), diazepam (1 mg/kg), midazolam (0,3 mg/kg), clonidine (1 mg/kg), atropine (2,7 mg/kg) with subanalgesic dose of morphine (1 mg/kg) in the somatogenic pain test (somatogenic pain was modelled with tail-flick). It was shown that the severity of the antinociceptive effect of morphine was significantly increased when combined with haloperidol, clonidine, gabapentin and metoclopramide; did not change when co-administered with midazolam and atropine; decreased when combined with diazepam.
INFLUENCE OF IRON DEFICIENCY ON THE CLINICAL STATE AND PARAMETERS OF CENTRAL HEMODYNAMICS IN PATIENTS WITH CHRONIC HEART FAILURE WITH PRESERVED EJECTION FRACTION
Authors: Smirnova M. P , Chizhov P. A , Baranov A. A , Ivanova Y. L
Published: September 2021

The clinical significance of iron deficiency in heart failure patients with preserved ejection fraction is not well understood. 158 patients with chronic heart failure with preserved ejection fraction were examined. The clinical manifestations of heart failure, the level of NT-proBNP, iron, ferritin, transferrin, were studied in all patients, echocardiography was performed in one-dimensional, two-dimensional, and Doppler modes (pulse-wave, constant-wave, and tissue) in standard positions according to the generally accepted technique. It has been established that iron deficiency in patients with heart failure with preserved ejection fraction worsens the indices of central hemodynamics and promotes an increase in the clinical manifestations of heart failure, especially in the development of anemia.
PRELIMINARY CLINICAL AND FUNCTIONAL RESULTS OF ASTIGMATISM CORRECTION AFTER PENETRATING KERATOPLASTY BY THE METHOD OF THE INTRASTROMAL CORNEAL SEGMENTS IMPLANTATION WITH THE APPLICATION OF A FEMTOSECOND LASER
Authors: Pozdeeva N. A , Kulikova I. L , Terentyev A. E , Sinitsyn M. V
Published: September 2021

The article presents an analysis of the clinical and functional results of astigmatism correction in 12 patients after penetrating keratoplasty by implantation of intrastromal corneal segments using a femtosecond laser. High refractive efficiency (increased visual acuity, flattening and increased regularity of the corneal graft) and safety in the correction of induced postkeratoplastic astigmatism were noted six months after the operation.
COMPARATIVE STUDY OF INDIVIDUAL AMINO ACIDS IN OVERGROUND PART OF GLYCYRRHIZA GLABRA L. AND GLYCYRRHIZA ECHINATA L
Authors: Yanitskaya A. V , Nedilko O. V , Ovsyankina O. V , Strakhov V. V
Published: September 2021

This article presents the results of a comparative analysis of the content of individual amino acids in the overground part of Glycyrrhiza glabra L. and Glycyrrhiza echinata L., growing in the Volgograd region. By the HPLC study, 16 amino acids (Ala, Gly, Tyr, Ser, Asp, Glu, Arg, His, Pro) were identified in the plant raw materials, among which 9 are replaceable amino acids and 7 are irreplaceable amino acids (Thr, Val, Met, Ile, Leu, Phen, Lys). At the same time, of the total content, the share of replaceable amino acids in Glycyrrhiza glabra L. is 10,09 %, and irreplaceable ones - 5,84 %. In the overground part of Glycyrrhiza echinata L., these indicators are slightly higher - 11,47 % of replaceable amino acids and 6,80 % of irreplaceable amino acids.
CUMULATIVE PROPERTIES OF THE NEW ANTI-MIGENOUS COMPOUND IN THE TABLET MEDICAL FORM
Authors: Kornilov V. I , Yakovlev D. S , Bagmetova V. V , Bugaeva L. I , Spasov A. A , Getmamenko A. Yu
Published: September 2021

Cumulative properties of 2-metoxifenil-imidazobenzimidazole derivative (RU-31) in tablet medical form (8 mg) were studied for development of new drug for migraine treatment. Four-week experiments were carried out on white rats of both sex, with intragastral administration of RU-31 water solution in the doses of 10 mg/kg and 100 mg/kg. On the 29th day the dose of tested compound equal to LD50 was administered to the animals. Due to the calculation of accumulation coefficient (more than 20 units) the tablet form of RU-31 shows the lack of cumulative properties.
THE NEAREST RESULTS OF LAPOROSCOPIC SURGERY FOR CARDIOSPASM (ACCORDING TO THE MATERIALS OF THE CLINIC)
Authors: Polyantsev A. A , Kotrunov V. V , Polyantsev A. A.(jr. , Zimin A. G , Glezer K. M
Published: September 2021

Aim of the research. To provide retrospective analysis of nearest results of laparoscopic surgery for cardiospasm (according to the materials of the department of thoracic surgery of the «Volgograd Regional clinical Hospital № 1» for 2018-2020). Materials and methods. The research include 32 laparoscopic surgical treatment cases of cardiospasm II-III stage. Results. Analysis of the nearest results of laparoscopic surgery for cardiospasm rated the advantages of the laparoscopic method in perfoming exstramucosal esophagocardiomyotomy are assessed. Conclusion. Marked decrease traumatism and time of the operation. Redused the patients hospital stay and postoperation rehabilitation was also redused in patients with II-III stage of the disease.
Mundo de formas
Authors: Maciel Lucas da Costa
Published: September 2021

Apresentação do dossiê “A estética e os ameríndios, ou Strathern nas Américas”.
Nutrition for Pre-school Children in Africa and Asia: A Review Analysis on the Economic Impact of Children’s Malnutrition
Authors: OKOLO Chukwuemeka Valentine , OKOLO Bartholomew Onyekachi , ANIKA Nneka Nancy
Published: September 2021

Nutrition is known to be the key driver in well-being and fitness generally, and as a driving force behind the growth of capital and child food, it is a source and a product of greater health problems, family income and living conditions. The first 1,000 days of maternal and child care concentrate on healthy physical exercise and cognitive improvement, with long-term health and economic consequences for people and economies. The research reviewed Nutrition for Preschool Children in Africa and Asia and illustrated the economic effect of malnutrition in infants. The review indicated that nutrition for pre-school children in Africa and Asia remains insufficient to ensure enhanced economic and human growth and that each nation needs to consider how money is to be invested through the assistance resources that help the least per cent of the population to fix this gap for children and make it the most efficient investment in society. Citizenship and collective efforts, particularly the voice of youth, are important forces of transformation, which must be encouraged to meet SDGs. Democracy campaigns can play a crucial role in the struggle for justice for children and the family.
Bűn – tudat : A magyarok büntetőjogi ismeretei és véleményei
Authors: Hollán Miklós , Venczel Tímea
Published: September 2021

A felnőtt magyar lakosság országos reprezentatív mintáján kérdőíves felmérés készült a büntetőjogi ismeretekről, amelynek összesített adatait elemezzük ebben a cikkben. A felmérés a „Büntetőjogunk szabályozási újdonságai – a jogtudatban” című hároméves kutatás része, melynek középpontjában az a kérdés áll, hogy a büntetőjogi újdonságok tükröződnek-e a jogtudatban. Igazolódott az a hipotézisünk, miszerint az átlagember sematikus ismeretekkel rendelkezik a büntetőjogról. Nem igazolódott azonban az a feltevésünk, hogy a jogismeretre hatással lennének a társadalmi-gazdasági tényezők, illetve a médiafogyasztás. A válaszadók (többnyire büntető) attitűdje viszont alapvetően befolyásolja a jogtudatot.
Femvertising : A nők társadalmi szerepének megerősödése és a reklámokkal való kapcsolata
Authors: Török Anna , Malota Erzsébet
Published: September 2021

A nők társadalmi szerepének megerősödése (female empowerment) egyre hangsúlyosabb szerepet kap a reklámokban. Az ilyen típusú, a nemi sztereotípiákat megkérdőjelző reklámozást femvertising-nek (female empowerment advertising) hívjuk. Tanulmányunk a nőkkel kapcsolatos társadalmi elvárásokat, a reklámokban megjelenő női sztereotípiákkal és a femvertisinggel kapcsolatos attitűdöket vizsgálja magyar nők körében, 10 félig strukturált mélyinterjú elemzésével. Vajon a nőknek jelenleg milyen társadalmi elvárásoknak kell megfelelniük Magyarországon? Milyen sztereotípiákat látnak mintaként a reklámokban és ez milyen hatással van rájuk? Hogyan valósulhat meg mindezek ellenére a nők társadalmi szerepének megerősödése? Eredményeink azt mutatják, hogy a családalapítás, a karrier és a gyönyörű külső együttes megvalósítása nyomásként nehezedik a nőkre.
Intraperszonális önszabályozás a biotechnológia korában : Aktuális médiatudományi és szociokulturális reflexiók Ted Chiang Szépségvakság című áldokumentum novellájára
Authors: Beke Ottó , Szűts Zoltán
Published: September 2021

Tanulmányunk középpontjában Ted Chiang Szépségvakság című novellája áll, mely forgatókönyv formátumával egy televíziós, illetve online formában sugárzott dokumentumműsor felépítését, dramaturgiáját követi. A történet középpontját egy, a szép észlelését megakadályozó fiktív állapot, az úgynevezett kalliagnózia képezi. A novella szereplői egy forgatókönyv – vagy inkább online fórum? – keretei között arról vitáznak, hogy ki kell-e terjeszteni ezt a mesterségesen kiváltható állapotot a társadalom nagyobb csoportjaira, az ötletet támogatók szerint ily módon véve elejét a lookizmusnak, vagyis a külső alapján történő megkülönböztetésnek, egyúttal hozzájárulva ezzel a társadalmi igazságosság előmozdításához, és az erkölcsi fejlődéshez. A novella olyan kérdéseket vet fel, amelyek vizsgálata elengedhetetlenül fontos és aktuális napjaink társadalmi, kulturális és médiakommunikációs környezetében, amikor a telekommunikációs folyamatokban és azokon túl is egyre inkább lehetővé válik az észlelés tárgyát képező kép- és hanganyag technikai befolyásolása.
Az idősek iránti attitűd és az idős fogyasztók ábrázolása a tv reklámokban Magyarországon
Authors: Hofmeister-Tóth Ágnes , Neulinger Ágnes
Published: September 2021

Az idősek reklámokban való alulreprezentáltságát számos nemzetközi kutatás vizsgálta, valamint korábbi hazai vizsgálatok is megállapították az idősek társadalmi jelentőségéhez képest kisebb mértékű megjelenését. Az alulreprezentáltság mellett további probléma, hogy a reklámok gyakran negatív sztereotípiák mentén mutatják be az időseket, amely kedvezőtlenül befolyásolhatja az idős generáció társadalmi megítélését. Kutatásunkban arra kerestük a választ, hogy milyen az idősekről kialakult vélemény, milyen asszociációk kötődnek az idősekhez és az időskorhoz, valamint milyen a lakosság észlelése az idősek reklámokban való megjelenéséről. Eredményeinkben részletesen bemutatjuk az időskép pozitív, semleges és negatív vonásait, az időskornak tulajdonított értékeket, valamint a médiában megjelenő idősképet és ennek észlelését.
Feasibility Design of an Optimized Desalinator Assisted Only by Solar Energy. Case: Saudi Arabia
Authors: Biain Jesús
Published: September 2021

Desalinators are traditionally driven by fossil-fuels but in order to avoid greenhouse emissions, renewable energy must be used. In this paper, a coupling between multi-stage flash distillation apparatus and a parabolic trough solar collector is analyzed. The purpose of this study is to determine the economic feasibility of the system, considering four cities of Saudi Arabia and three different potable water productions. To avoid solar energy intermittency and unavailability at night, thermal storage is implemented. Whereas other researchers made parametric analyses, in this paper, the authors developed a mathematical program which was optimized with the help of GAMS software, where the capital cost of the plant was the objective function. After that, a life cycle cost analysis was carried out for each scenario. Depending on the region and water production, the costs of drinking water vary from 2.26 to 3.93 US$/m3, and from 7440 to 23825 tons of carbon dioxide emissions are avoided. As a consequence of the approach used, low costs are obtained; even though no auxiliary heater is implemented and the lowest irradiance conditions are considered. The results of this study reflect that the proposed process is competitive with respect to the traditional one.
Performance testing and modeling of a transpired ventilation preheat solar wall : performance evaluation of facilities at Fort Drum, NY, and Kansas Air National Guard, Topeka, KS
Authors: Wallace Sean , Lux Scott , Mitsingas Constandinos , Andsager Irene , Patel Tapan
Published: September 2021

This work performed measurement and verification of installed, operational solar wall systems at Fort Drum, NY, and Forbes Field, Air National Guard, Topeka, KS. Actual annual savings were compared estimated savings generated by a solar wall modeling tool (RETScreen). A comparison with the RETScreen modeling tool shows that the measured actively heated air provided by the solar wall provides 57% more heat than the RETScreen tool predicted, after accounting for boiler efficiency. The solar wall at Fort Drum yields a net savings of $851/yr, for a simple payback of 146 years and a SIR of 0.16. RETScreen models indicate that the solar wall system at Forbes Field, Kansas Air National Guard, Topeka, KS saves $9,350/yr, for a simple payback of 58.8 years and a SIR of 0.34. Although results showed that, due to low natural gas prices, the Fort Drum system was not economically viable, it was recommended that the system still be used to meet renewable energy and fossil fuel reduction goals. The current system becomes economical (SIR 1.00) at a natural gas rate of $16.00/MMBTU or $1.60 /therm.
Autonomous navigation and mapping in a simulated environment
Authors: Christie Benjamin , Ennasr Osama , Glaspell Garry
Published: September 2021

Unknown Environment Exploration (UEE) with an Unmanned Ground Vehicle (UGV) is extremely challenging. This report investigates a frontier exploration approach, in simulation, that leverages Simultaneous Localization And Mapping (SLAM) to efficiently explore unknown areas by finding navigable routes. The solution utilizes a diverse sensor payload that includes wheel encoders, three-dimensional (3-D) LIDAR, and Red, Green, Blue and Depth (RGBD) cameras. The main goal of this effort is to leverage frontier-based exploration with a UGV to produce a 3-D map (up to 10 cm resolution). The solution provided leverages the Robot Operating System (ROS).
The Cut-off Values of Triglycerides - Glucose Index for Metabolic Syndrome Associated with Type 2 Diabetes Mellitus
Authors: Hameed Ekhlas K. , Al-Ameri Laith T. , Hasan Hayder S. , Abdulqahar Zina H.
Published: September 2021

The co-occurrence of metabolic syndrome with type 2 diabetes mellitus (T2DM) will potentiate the morbidity and mortality that may be associated with each case. Fasting triglycerides-glucose index (TyG index) has been recommended as a useful marker to predict metabolic syndrome. Our study aimed to introduce gender-specific cut-off values of triglycerides- glucose index   for diagnosing metabolic syndrome associated with type 2 diabetes mellitus. The data were collected from Baghdad hospitals between May - December 2019. The number of eligible participants was 424. National cholesterol education program, Adult Treatment Panel III criteria were used to define metabolic syndrome. Measurement of fasting blood glucose, lipid profile, HbA1c level, blood pressure, and anthropometric were done and the triglyceride-glucose index was calculated. Ethical approval and informed consent were obtained .SPSS was used to analyze the data. Diabetic patients with metabolic syndrome showed an increased level of TyG Index. The prevalence of metabolic syndrome increased with increased TyG index quartiles. The TyG-Index showed significant correlations with all components of metabolic syndrome. The optimal cut-off value revealed 9.14, 9.28 for males and females respectively. In conclusion, TyG index is a good predictor of the presence of MetS in T2DM the TyG index, just measured in one laboratory test, is simple, informative and more suitable for the detection of metabolic syndrome in Iraqi type 2 diabetes mellitus.
Iron (II) Determination in Lipstick Samples using Spectrophotometric and Microfluidic Paper-based Analytical Device (µPADs) Platform via Complexation Reaction with Iron Chelator 1, 10-phenanthroline: A Comparative Study
Authors: Abdulkareem Ekhlas A. , Abdulsattar Jwan O. , Abdulsattar Ban O.
Published: September 2021

This study was undertaken to introduce a fast, accurate, selective, simple and environment-friendly colorimetric method to determine iron (II) concentration in different lipstick brands imported or manufactured locally in Baghdad, Iraq. The samples were collected from 500-Iraqi dinars stores to establish routine tests using the spectrophotometric method and compared with a new microfluidic paper-based analytical device (µPAD) platform as an alternative to cost-effective conventional instrumentation such as Atomic Absorption Spectroscopy (AAS). This method depends on the reaction between iron (II) with iron(II) selective chelator 1, 10-phenanthroline(phen) in the presence of reducing agent hydroxylamine (HOA) and sodium acetate (NaOAc) buffer to yield a reddish/orange colour change proportional to the iron(II) concentration measured at λmax = 510 nm. Under optimum conditions, the calibration curve was linear in the range between (0.5-150) mg L-1 with a limit of detection of 0.09 mg L-1. Compared to a spectrophotometric detection method, µPAD measured colour intensity using captured images using Samsung mobile phone and image J program to give proof of concept that µPAD platform fulfils the purpose of accuracy and at the same time remaining cost-effective and simplistic to be used in both developing and developed countries gave same linear calibration curve with a limit of detection 0.12 mg L-1. ANOVA test was used to compare the proposed method results with conventional method results showing the method was accepted. The antimicrobial activity showed no significant effect from lipstick samples on tested microbes.
Synthesis and Characterization of New Benzothiazole-derived Schiff Bases Metal Complexes
Authors: Mahmood Wasan Abdul Razzaq , Aldabbagh Areej Kamal Assim , Mahmoud Muhanned A.
Published: September 2021

Nitrogen-comprising heterocyclic compounds and their derivatives have empirically been invaluable as therapeutic agents. Fundamentally, 4-chloro-6-nitro-2-amino-1,3-benzothiazole 1 was synthesized via bromination of 2-chloro-4-nitro aniline with ammonium thiocyanate. This new heterocyclic haloorganoamino-1,3-benzothiazole derivative, was a starting material, which condensed and tethered with three different aromatic aldehyde pendant arm in presence of ethanol and glacial acetic acid isolating an interesting sequence of tridentate Schiff bases 2-4. These compounds were used for complexation reactions in 1:1 (metal: ligand) stoichiometry to obtain heteroleptic Al(III), Ni (II) and K(I) benzothiazole chelates 5-7(a-c) of the type [Al(L)Cl2, Ni(L)Cl, K(L) {L = Schiff base derivatives}]. The newly synthesized complexes were characterized by the melting points, IR and some of them by 1H-NMR spectroscopy and only one by X-ray techniques. The structures of complexes were anticipated from the spectroscopic studies.
Chloride Accumulation in Aboveground Biomass of Three Macrophytes (Phragmites Australis, Juncus Maritimus, and Typha Latifolia) Depending on Their Growth Stages and Salinity Exposure. Application for Cl- Removal and Phytodesalinization.
Authors: Delattre Emmanuel , TECHER Isabelle , Reneaud Benjamin , Verdoux Patrick , Laffont-Schwob Isabelle , Prohin Philippe
Published: September 2021

Anthropogenic activities can be the source of saline solid wastes that need to be treated to reduce their salt load to meet the purposes of reuse, valorization or storage. In this context, chloride remediation can be achieved using high-salt accumulating plants. However, there is very limited information on the comparative potential of different species in the same environment, and only scarce data concerning their efficiency as a function of growth stage. In order to rationalize these selection criteria, three macrophytes i.e. common reed (Phragmites australis), sea rush (Juncus maritimus) and cattail (Typha latifolia) were cultivated at two growth stages (6-months old and 1-year old) for 65 days in Cl- spiked substrates (from 0 up to 24 ‰ NaCl). The plants’ survival and potential capacity for removal of Cl- from substrates and accumulation in shoots were investigated. For the three studied species, mature and juvenile plants display a high tolerance to salinity. However, mature specimens with higher shoot biomass and Cl- contents are capable of greater chloride removal than juvenile plants. The sole exception is P. australis which displays just the same phytoremediation potential for both mature and juvenile specimens. Moreover, P. australis has the lowest potential when compared with other species, being 1.5 and 3 times lower than for J. maritimus and T. latifolia. When considering the plant growth and the shoot biomass production, chloride removal rates from the substrate point that mature J. maritimus should preferentially be used to design an operational chloride remediation system. The results highlight the relevance of considering the growth stage of plants used for Cl- removal.
Natural geometric unit system and electron magnetic moment anomaly
Authors: Kowalski Janusz "Jani"
Published: September 2021

Consequences of implementation of the natural geometric unit system (the SG) based on the pre-2019 SI system, in which four fundamental physical constants undergo joint numerical and dimensional normalization to unity c = G= k = h = 1, with only one base geometric unit u equal to √|h · G/c 3 | m, where the Newtonian gravitational constant G ≈ 6.673 655 205 · 10 -11 m3/(kg · s 2 ), are further explored. In addition to the earlier hypothesized simple electron mass to charge ratio formula me = e/(2 9πα), and formulas for stable quarks rest masses: quark u mu = √(⅔) / (2 7π √(πα)) u, equivalent of 2.360 MeV/c 2 and quark d md = √(⅓) -1 / (2 7π √(πα)) u, equivalent of 5.007 MeV/c 2 , a simple formula for electron magnetic moment anomaly is proposed α/2π - (α/2π) 2 - 2 8 (α/2π) 3 - 2 12 (α/2π) 4 - 2 16 (α/2π) 5 - 2 24 (α/2π) 6 ≈ 0.001 159 652 180. The finding supports the research area of purely geometric modelling of the fundamental physical forces and their unification. It seems plausible, that in the SG, with use of half integer powers of 2, 3, π and α only,all the fundamental properties of stable matter and electromagnetic radiation could be described
Dental pulp stem cells as a therapy for congenital entero-neuropathy
Authors: Yoshimaru Koichiro , Yamaza Takayoshi , Kajioka Shunichi , Sonoda Soichiro , Yanagi Yusuke , Matsuura Toshiharu , Yoshizumi Junko , Oda Yoshinao , Iwata Naoko , Takai Chiho , Nakayama Shinsuke , Taguchi Tomoaki
Published: September 2021

Hirschsprung’s disease (HSCR) and its allied disorders are congenital entero-neuropathies with life-long implications in many cases. Here we report the effects of intravenous transplantation of cultured dental pulp stem cells derived from deciduous teeth (dDPSCs) into ‘Japanese fancy-1’ (JF1) mice with entero-neuropathy caused by Ednrb mutation. Intravenously injected dDPSCs (multipotent neural crest cells with low immunogenicity) migrated to affected regions of the intestine through interactions between stromal cell-derived factor-1α and C-X-C chemokine receptor type-4. Notably, transplanted dDPSCs differentiated into both enteric neurons and pacemaker interstitial cells to correct abnormalities in the electrical and mechanical activities of the proximal colon. dDPSC transplantation also led to repair of the small intestinal mucosa, changes in the gastrointestinal microbiota, improvements in nutritional status and prolongation of survival. We anticipate that dDPSC transplantation could be developed into a novel cell-based therapy for HSCR and its allied disorders.
Ultra-High Nonlinear Lead Silicate Photonic Crystal Fiber with Two Zero Dispersion for Supercontinuum Generation Applications
Authors: Gupta Pradeep Kumar , Akhouri Binay Prakash , Kumar Abhishek , Mishra Manoj , Singh Brajraj , Sharma Mohit
Published: September 2021

This paper presents a unique type of Lead silicate (SF57) photonic crystal fiber (PCF) with eleven rings of air holes. The PCF promises to yield very large nonlinearity ~13169 W −1 km −1 at 0.75 𝜇𝑚, ~8607 W^(-1) km^(-1) at 1.064 μm and ~4640 W^(-1) km^(-1) at 1.55 μm. The PCF has two zero dispersion at wavelength 0.3 μm and 1.50 μm . The value of nonlinearities is highest reported till now. The PCF contains very low optical mode field, causes large nonlinearity which makes it best suitable PCF for generating supercontinuum.
Ambulatory Blood Pressure Control Pattern in Hypertensive Patients at Tikur Anbesa Specialized Hospital: A Cross Sectional Study
Authors: ALEMAYEHU MULUALEM , Abebe Sintayehu , Yadeta Dejuma , Alemayehu Bekele
Published: September 2021

Background: Hypertension is the most common cardiovascular problem globally with a particularly increasing burden in developing countries like Ethiopia. Ambulatory blood pressure (ABPM) is superior to office blood pressure (OBP) measurement for diagnosing, prognosticating and following treatment efficacy for hypertension. There is no available data on ABPM control pattern in Ethiopians. This study will determine the ABPM control patterns in Ethiopian hypertensive patients on treatment. Material and Methods: This was a cross sectional study in hypertensive patients at Tikur Anbessa Specialized Hospitals outpatient departments carried out during January to May 2021. ABPM values of 244 consecutively sampled patients were analyzed. All patients had their BP monitored over 24 h with a Tonoport V (GE CS V6 71), and the data was interpreted using GE CardiosoftTM ABPM software in accordance with European Society of hypertension guidelines. Ethical clearance was given by Addis Ababa University Institutional Review Board and the study was conducted in compliance to standard ethical guidelines.Results: The study involved 244 adult hypertensive patients; mean age of the patients was 59.4years and, 54% were females. 58.6% of patients had controlled OBP, while only 45.1% had controlled ABPM. The mean OBP was 137 (19)/81 (10) mmHg and mean 24-hr ABP was 137 (16)/81 (10) mmHg; mean daytime BP was 136/79 ± 17/11 mmHg; mean night‑time BP, 138/84 ± 16/11 mmHg. Mean ABPM values were not significantly different between men and women. Comparison of ABPM values with OBP revealed high prevalence of the white coat effect (32%) and masked uncontrolled hypertension (46%). Presence of comorbidities particularly diabetes predicted poor ABPM control.Conclusion: More than half of patients had uncontrolled BP as per ABPM criteria and significant discrepancy exists between ABPM and OBP in assessing adequacy of BP control. Guiding management decisions using ABPM can improve BP control rates.
Genetic Evaluation and Screening of Diverse Wheat Genotypes for Spot Blotch Resistance
Authors: Roy Pritam , Gorai Shouvik , Bhattacharya Sudip , Murmu Mousumi , Hazra Soham , Mukherjee Subhra , Mukherjee Dhiman , Maji Anirban
Published: September 2021

Production of wheat (Triticum aestivum L.) the main food source of South Asian countries including India faces several constraints including spot blotch caused by Bipolaris sorokiniana resulting in yield loss of 25–43 % depending upon the stage of infection. Fifty genotypes were evaluated for nine quantitative characters and area under disease progress curve (AUDPC) to identify superior genotype with spot blotch resistance. High heritability coupled with moderate to high genetic advance as percent of mean was registered for grains per spike, tillers per square meter, days to 50% heading and days to 50% flowering indicating the characters to be governed by additive genes. Correlation and path coefficient analysis favored days to 50% heading, days to 50% flowering and grains per spike since they had significant positive correlation with yield and simultaneous negative correlation with AUDPC and also conferring highest positive direct effect towards yield. Multiple linear regression (MLR) analysis indicated days to 50% heading to be most sensitive with negative influence on AUDPC. D2 analysis grouped the 50 genotypes into 10 clusters suggesting presence of diversity among the genotypes. Frequency distribution of AUDPC among the genotypes showed more or less normal distribution of the character. Low AUDPC score with acceptable level of yield performance were recorded for the genotypes 29882, 29610, 29473, 29940, 29477, 29748 and 30081. Identification of high yielding and less susceptible genotypes for spot blotch disease in the present investigation offered an opportunity for wheat improvement through selective breeding.
Khat Chewing and Relapse in Peoples With Serious Mental Illness At Amanuel Mental Specialized Hospital: Comparative Study
Authors: Habte Fikreselam , Kassaw Chalelgn , Gedamu Melak , Asfaw Getachew , Abebaw Dessie , Haile Kibrom , Tulu Mikiyas
Published: September 2021

Background

people with serious mental illness using illicit drug exhibit poorer outcomes. But until now little is known about the impact of khat in thiss patient group. This study tried to assess the effect of khat chewing on relapse in people with serious mental illness.
Method

This is cross sectional comparative study involving 405 khat chewers and 400 non chewer people with serious mental illness. The study took three month involving interview (patient and care giver) and chart review. The study used Oslo Social Support Scale; Alcohol, Smoking, Substance Involvement Screening Test and questionnaire which include sociodemographic characteristics, illness related factors and relapse history.
Result

The study found that prevalence of relapse was higher in khat chewes than in non chewers (22% Vs 13%, p = 0.001) in people with serious mental illness. Additionally, the prevalence of relapse was also increased as the risk from use of khat was increased. In the khat chewer group previous hospitalization histories and presence of stressful life situation were the factor associated with relapse. On the otherhand treatment interruption, sleep disorder and previous hospitalization were the factors associated with relapse in non khat chewer people with serious mental illness.
Conclusion

Khat chewing poses additional burden for the already debilitating disease. Patient care should consider khat chewing as one of the components for intervention.
A Comprehensive Physiologically Based Pharmacokinetic (PBPK) Model for Nicotine in Humans Including Deposition and Diffusion in the Buccal and Respiratory Tissues from Using Different Nicotine-Containing Products with Different Routes of Exposure
Authors: Rostami Ali , Campbell Jerry , Pithawalla Yezdi , Pourhashem Hamideh , Muhammad-Kah Raheema , Sarkar Mohamadi , Liu Jianmin , McKinney Willie , Gentry Robinan , Gogova Maria
Published: September 2021

Physiologically based pharmacokinetic (PBPK) modeling can be a useful tool for characterizing nicotine pharmacokinetics (PK) from use of tobacco products. We expand a previously published PBPK model to simulate a nicotine PK profile, following single or multiple use of various tobacco products (cigarettes, smokeless tobacco, and electronic nicotine delivery systems, or a nicotine inhaler (Nicotrol®). The uptake route in the model was designed to allow for three uptake compartments: buccal cavity (BC), upper respiratory tract (URT) (conducting and transitional airways) and lower respiratory tract (alveolar region). Within each region, the model includes product-specific descriptions of the flux of nicotine into plasma, as well as the flux of nicotine from the BC and URT to the gastrointestinal tract. These descriptions are based on regional deposition and diffusion models of nicotine into plasma, which depends on the product type. Regional deposition flux combined with regional differences in physiological parameters (e.g., blood perfusion ratio and tissue thickness) play a key role in the product-specific PK profile of nicotine. The current model describes the slower flux of nicotine into plasma across the BC and URT, as well as the rapid flux known to occur in the alveolar region. Overall, the addition of the BC and respiratory tract compartments to the nicotine model provided simulation results that are comparable to the nicotine time-course plasma concentrations reported from clinical studies for the four product categories simulated.
Holmium laser-assisted laparoscopic partial cystectomy for bladder cancer: technical feasibility and outcome
Authors: Kim Kang Sup , Kim Sang Hoon , Cho Hyuk Jin , Sur Hong Jin , Choi Yong Sun
Published: September 2021

BackgroundIn selected patients with bladder cancer, partial cystectomy is an alternative treatment for bladder preservation with fair oncologic result. During partial cystectomy, tumor margin demarcation is difficult. Various methods were introduced, however, there is no standard for tumor margin demarcation. We aimed to introduce and provide our experience with holmium laser-assisted method with ten patients.MethodsFrom March 2016 and February 2019, patients who want partial cystectomy for bladder cancer were enrolled in this study. Inclusion criteria were stage T2 or T3 disease and tumor location restricted within the dome, and lateral, posterior side of the bladder were included. Transurethral holmium laser-assisted mucosal incision was made and deepened until perivesical fat. Minimal Safety margin for 5–10 mm were spared, and tumor removal was done laparoscopically.ResultsTen patients underwent holmium laser-assisted laparoscopic partial cystectomy. All procedures were done without complication. The tumor locations were laterally in seven patients, dome in two patients, and posterior wall in one patient. Pathologic examination of surgical margin showed no cancer cell involvement in all cases. There were no recurrences or metastases for 12 months follow up.ConclusionsHolmium laser-assisted laparoscopic partial cystectomy is effective and safe technique. To achieve precise and appropriate surgical margin during the laparoscopic partial cystectomy, holmium laser resection provides feasible and safe method that assists in bladder incision with minimal ureteral orifice involvement.Trial registrationRetrospectively registered.
Significance of TP53 Mutational Status-Associated Signature in the Progression and Prognosis of Endometrial Carcinoma
Authors: Zhao Wancheng , Bi Fangfang , Pan Xue
Published: September 2021

Background:TP53 mutations are associated with poor outcome for patients with endometrial carcinoma (EC). However, to date, there have been no studies focused on the construction of TP53 mutational status-associated signature in EC. In this study, we aim to conduct a TP53 mutation associated prognostic genes signature for EC.Methods: Hence, we explored the mutational landscape of TP53 in patients with EC based on the simple nucleotide variation data downloaded from The Cancer Genome Atlas (TCGA) database. Differential expression analysis and least absolute shrinkage and selection operator (LASSO)–Cox analysis was used to establish TP53 mutation associated prognostic genes signature. The overall survival rate between the high-risk and low-risk groups was compared by Kaplan-Meier (K-M) method. Results: We found that the TP53 mutation was associated with poor outcome, older age, lower BMI, and higher grade and stage of EC in patients. A TP53 mutational status-associated signature was established based on transcriptome profiling data. Moreover, the patients in TCGA database were categorized into high- and low-risk groups. Kaplan–Meier (K-M) analysis indicated that the patients in the high-risk group have poor survival outcome. Furthermore, receiver operating characteristic (ROC) curves confirmed the robust prognostic prediction efficiency of the TP53 mutational status-associated signature. Finally, the prognostic ability was successfully verified in the other two datasets from cBioPortal database as well as in 60 clinical specimens.Conclusion: In summary, our research constructed a powerful TP53 mutational status-associated signature that could be a potential novel prognostic biomarker and therapeutic target for EC.
Research on Carbon Productivity and It's Spatial Convergence of Steel Industry in China
Authors: Wang Xiping , Tang Rong
Published: September 2021

The Global-Malmquist-Luenberger (GML) index was applied to analyse the carbon productivity in steel industry (SICP) of 29 provinces in China from 2006 to 2017, and then the SICP was decomposed into technical efficiency change index (TC) and technical progress index (EC). On this basis, the spatial effect is introduced into the traditional convergence model to investigate the spatial convergence of SICP. The empirical results show that: (1) The overall carbon productivity of China's steel industry is at a relatively low level, showing a slow growth trend. (2) The average value of the GML index of SICP is higher than 1, showing obvious inter-provincial and regional heterogeneity. Compared with EC, TC is the leading factor that promotes the increase of SICP. (3) The spatial absolute and condition β convergence of SICP exist in the whole country and the three major regions, but the σ convergence feature is not significant. The addition of spatial factors speeds up the convergence trend, and the speed of spatial absolute β convergence is about 3 times that of the classical convergence model. At the same time, the conditional convergence rate is significantly faster than the absolute convergence, which is closely related to the differences in influencing factors such as the industrial structure, economic development level, human capital, energy consumption intensity, and R&D investment among regions. There is still much room for improvement in carbon productivity in China's steel industry, and investment in scientific research must be increased in order to achieve the upgrading of the industrial structure and technological innovation. The existence of spatial convergence requires strengthening the joint reorganization of steel enterprises between provinces and regions, making full use of the spatial spillover effects of production technology, and realizing regional green and coordinated development.
Indoor, outdoor and ICU Environment monitoring of COVID-19
Authors: Santos Nathalia Villa , Waked Dunia , Wicik Zofia , Gomes-Gouvêa Michele Soares , Pinho João Renato Rebello , Levin Anna Sara Shefferman , Ho Yeh-Li , Veras Mariana Matera
Published: September 2021

The disease caused by the SARS-CoV-2 virus, which originated in Wuhan, Hubei Province, China, in December 2019 spread rapidly, causing a high number of deaths worldwide. The difficult ability to contain the transmission of the disease raised doubts about the possible forms of contamination. Studies have shown an increase in new cases of the disease on days when the level of pollution was high, raising questions that pollutants may be carriers of the virus. In this study, we investigated the involvement of fine particulate matter (PM2.5) in virus loading in common circulation (indoor and outdoor) environments and in the intensive care unit (ICU) of a hospital. PM2.5 was collected from May to November 2020, and the collection time per day was 48 to 72 h. After collection, the material was stored at a temperature of -80°C until the moment of analysis. Our results demonstrated that SARS-CoV-2 can be found in fine particulate material (PM2.5), but there is an essential interference of temperature, humidity and UV rays in the preservation of viral RNA.
Modelling the Prevalence of Hepatitis B Towards Eliminating It as a Major Public Health Threat in China
Authors: Liu Wenjun , Zhuang Tianyi , Xia Ruyi , Zou Zhuoru , Zhang Lei , Shen Mingwang , Zhuang Guihua
Published: September 2021

Background: The World Health Organization (WHO) requires a reduction in the prevalence of hepatitis B virus (HBV) surface antigen (HBsAg) in children to 0.1% by 2030, a key indicator for eliminating viral hepatitis as a major public health threat. Whether and how China can achieve this target remains unknown, although great achievements have been made. We aimed to predict the decline of HBsAg prevalence in China and identify key developments needed to achieve the target.Methods: An age- and time-dependent dynamic compartmental model was constructed based on the natural history of HBV infection and the national history and current status of hepatitis B control. The model was run from 2006 to 2040 to predict the decline of HBsAg prevalence under three scenarios including maintaining current interventions (status quo), status quo + peripartum antiviral prophylaxis (recommended by WHO in 2020), and scaling up available interventions.Results: Under the status quo, HBsAg prevalence would decrease steadily in all age groups, but the WHO’s target of 0.1% prevalence in children aged < 5 years would not be achieved until 2037. The results are robust according to sensitivity analyses. Under the status quo + antiviral prophylaxis, the HBsAg prevalence of children aged < 5 years would significantly decrease with the introduction of peripartum antiviral prophylaxis, and the higher the successful interruption coverage is achieved, the more significant the decline. However, even if the successful interruption coverage reaches 90% by 2030, the 0.1% prevalence target would not be met until 2031. Under the scaling up available interventions, combined with scale-up of current interventions, the WHO’s 0.1% target would be achieved on time or one year in advance if peripartum antiviral prophylaxis is introduced and the successful interruption coverage is scaled up to 80% or 90% by 2030, respectively.Conclusions: It is difficult for China to achieve the WHO’s target of 0.1% HBsAg prevalence in children by 2030 by maintaining current interventions. Peripartum antiviral prophylaxis may play an important role to shorten the time to achieve the target. A comprehensive scale-up of available interventions including peripartum antiviral prophylaxis will ensure that China achieves the target on schedule.