bluuebunny/crossref_metadata_2025 huggingface dataset:
Anti- helicobacter pylori effect of total alkaloids of sophora alopecuroides in vivo
Authors: Aiping Tian , Ting Xu , Kaiyun Liu , Quanming Zou , Xiang Yan
Published: January 2024

Background

Helicobacter pylori (H. pylori) infection could lead to most gastroduodenal diseases and is even identified as a carcinogen of gastric cancer. Total alkaloids of sophora alopecuroides (TASA) is widely used in herbal remedies to treat various infectious diseases, including stomach-associated diseases. This study is aimed at evaluating the antimicrobial activity of TASA on H. pylori-infected BALB/c mice mouse gastritis.

Methods

Totally 120 BALB/c mice were orally inoculated with H. pylori Bacterial liquid to construct BALB/c mice H. pylori infection gastritis animal model, after the model was successfully created. We randomly assigned 100 infected mice into 10 treatment groups, the first group (normal saline); the second group (bismuth pectin); the third group (omeprazole); the fourth group (TASA 2 mg/d); the fifth group (TASA 4 mg/d); the sixth group (TASA 5 mg/d); the seventh group (TASA + bismuth pectin); the eighth group (TASA + omeprazole); the ninth group (bismuth pectin + clarithromycin + metronidazole); the tenth group (omeprazole + clarithromycin + metronidazole), 5 other non-infected mice as negative control. Mice were orally inoculated twice a day and 7 days continuously. Then the mice were killed 4 weeks after treatment, we used real-time PCR to detect 16sDNA of H. pylori to test both the colonization and the clearance mice of bacteria of each treatment. We applied hematoxylin and eosin (HE) staining and immunostaining of mice gastric mucosa to observe the general inflammation and related factors interleukin 8 (IL-8), cyclooxygenase 2 (COX-2), and nuclear factor-kappa B (NF-κB) expression change after treatments.

Results

Firstly, we ensured that after 6-week intragastric administration, the bacteria colonization reached an exceed peak which is far higher than positive threshold (P <0.001); secondly, after treatments, it is revealed that TASA combined with omeprazole or bismuth pectin showed promising antimicrobial activity against H. pylori as well as conventional triple therapy (P <0.001); thirdly, HE staining showed that the inflammation on mice gastric mucosal membrane were also relieved obviously in TASA combined treatments and conventional triple therapy compared with normal saline treated mice, moreover, from immunohistochemistry results, H. pylori-induced IL-8, COX-2, and NF-κB were consistently suppressed in seventh, eighth, ninth, and tenth group to a certain extent.

Conclusion

These results open the possibility of taking TASA as an anti-inflammatory agent for H. pylori gastritis.
Mizoribine versus mycophenolate mofetil or intravenous cyclophosphamide for induction treatment of active lupus nephritis
Authors: Feng Xuebing , Gu Fei , Chen Weiwei , Liu Yan , Wei Hua , Liu Lin , Yin Songlou , Da Zhanyun , Sun Lingyun
Published: January 2024

Background

Lupus nephritis (LN) is one of the most serious manifestations of systemic lupus erythematosus. Although there have been substantial improvements in LN treatment over the last decade, the outcome remains unoptimistic in a considerable percentage of patients. The aim of this study was to evaluate the efficacy and safety of mizoribine (MZR), a novel selective inhibitor of inosine monophosphate dehydrogenase, as induction treatment for active LN in comparison with mycophenolate mofetil (MMF) and intravenous cyclophosphamide (CYC).

Methods

Ninety patients with active LN were observed. Thirty patients were given MZR orally at the dose of 300 mg every other day. Thirty patients took MMF at 2 g per day in two divided doses. Thirty patients received CYC intravenously 0.5 g every 2 weeks. Therapeutic effects and adverse events (AEs) were evaluated at the end of 24-week treatment. One-way analysis of variance (ANOVA) followed by Dunn's test was applied to compare the difference among the groups. For comparing categorical data between two groups, χ2 test was employed.

Results

Early responses at week 12 were achieved by 73.3%, 90.0%, and 96.7% in MZR, MMF, and CYC groups, respectively. There was no significant difference in the complete remission rates (22.7%, 24.0%, and 25.0%, respectively) or overall response rates (68.2%, 72.0%, and 75.0%, respectively) among the three groups at week 24. The most prominent drop-down of Systemic Lupus Erythematosus Disease Activity Index scores was observed in MMF or CYC group, and the decline of health assessment questionnaire scores in MZR or MMF group was more prominent than that in the CYC group at week 12. Serum complement 3 (C3) or C4 levels were elevated in all groups after the treatments. CYC was more effective in inhibiting anti-double-stranded DNA antibody, while MZR was more effective in inhibiting antinuclear antibody. The incidences of AEs in patients treated with CYC were significantly higher than those in patients treated with MZR or MMF (24.2% for CYC vs. 3.3% for MZR, and 2.6% for MMF, P=0.01).

Conclusions

MZR is well tolerated and has an effect similar to MMF in the induction therapy of active LN. MZR may serve as an alternative approach for LN patients.
Acute calculous cholecystitis associated with hepatic artery pseudoaneurysm after percutaneous transhepatic gallbladder drainage in a diabetic patient
Authors: Hu Tian , Mingfeng Xia , Shuai Zhang , Jie Li , Ju Liu
Published: January 2024

Patients with acute calculous cholecystitis are usually undertaken surgery laparoscopic cholecystectomy. However, there are controversies about the decision of operation for patients with high risk factors. Percutaneous transhepatic gallbladder drainage (PTGD) is palliative therapy to alleviate symptoms and physical signs. Since improved clinical outcome has been observed for PTGD, it was recommended as an initial therapeutic option for high risk patients who might need surgery.1 Percutaneous drainage in acute calculous cholecystitis for high risk patients is to be a safe and successful treatment option for patients less eligible for surgery.2 PTGD is relatively safe, but has certain complications. We provided a case report of acute calculous cholecystitis associated with hepatic artery pseudoaneurysm after PTGD in a diabetes mellitus patient. The liver vascular pseudoaneurysms and secondary changes of liver were documented by the imaging examination. The complex interactions among inflammation, bleeding, and diabetes mellitus were involved in this case.
Prognostic analysis of orthostatic intolerance using survival model in children
Authors: Li Yawen , Li Hongxia , Li Xueying , Li Xiaoming , Jin Hongfang
Published: January 2024

Background

Orthostatic intolerance (OI) is a common disease at pediatric period which has a serious impact on physical and mental health of children. The purpose of this study was to investigate the effect of related factors on the prognosis of children with OI.

Methods

The subjects were 170 children with OI, including 71 males (41.8%) and 99 females (58.2%) with age from 6 to 17 (12.0±2.6) years. The effect of related factors on the prognosis of children was studied by using univariate analysis. Then, the impact of children's age, symptom score, duration, disease subtype, and treatment on patient's prognosis was studied via analysis of COX proportional conversion model.

Results

Among 170 cases, 48 were diagnosed with vasovagal syncope, including 28 cases of vasoinhibitory type, 16 cases of mixed type, and 4 cases of cardioinhibitory type; 115 cases were diagnosed with postural tachycardia syndrome and 7 cases with orthostatic hypotension. By using univariate analysis of Cox regression, the results showed that symptom score had a marked impact on the time of symptoms improvement of children after taking medication (P<0.05), while other univariates had no impact (P>0.05). Multivariate analysis using Cox proportional hazards regression model showed that the symptom score at diagnosis had a significant effect on holding time of symptoms improvement of children after taking medication (P<0.05). Kaplan-Meier curve showed that symptom-free survival was higher in children with symptom score equal to 1 than children with symptom score equal to or greater than 2 during follow-up (P<0.05).

Conclusion

Symptom score is an important factor affecting the time of symptom improvement after treatment for children with OI.
Prognosis of R1-resection at the bronchial stump in patients with non-small cell lung cancer
Authors: Jima Lyu , Xuezhi Hao , Zhouguang Hui , Jun Liang , Zongmei Zhou , Qinfu Feng , Zefen Xiao , Dongfu Chen , Hongxing Zhang , Lyuhua Wang
Published: January 2024

Background

The prognosis of R1-resection at the bronchial stump in patients with non-small cell lung cancer (NSCLC) remains unclear. This study intends to identify the prognostic factors and to optimize treatments for these patients under update conditions.

Methods

The data of 124 NSCLC patients who underwent R1-resection at the bronchial stump was reviewed. There were 41 patients in the surgery group (S), 21 in the postoperative radiotherapy (PORT) group (S+R), 30 in the postoperative chemotherapy (POCT) group (S+C), and 32 in the PORT plus POCT group (S+R+C). The constitute proportion in different groups was tested using the χ2 method, univariate analysis was performed using the Kaplan-Meier and log-rank method, and multivariate analysis was done using the Cox hazard regression with entry factors including age, sex, pathological type and stage, classification of the residual disease, and treatment procedure. The process was performed stepwise backward with a maximum iteration of 20 and an entry possibility of 0.05 as well as an excluded possibility of 0.10 at each step.

Results

In univariate analysis, survival was more favorable for patients with squamous cell carcinoma, early pathological T or N stage, and chemotherapy or radiotherapy. There was no significant difference in the survival for patients with different types of the residual disease, except for the difference between patients with carcinoma in situ and lymphangiosis carcinomatosa (P=0.030). The survival for patients receiving chemoradiotherapy was superior to that for those undergoing surgery alone (P=0.016). In multivariate analysis, the pathological type (HR 2.51, 95% CI 1.59 to 3.96, P=0.000), pathological T (HR 1.29, 95% CI 1.04 to 1.60, P=0.021) or N stage (HR 2.04, 95% CI 1.40 to 2.98, P=0.000), and chemotherapy (HR 0.24, 95% CI 0.13 to 0.43, P=0.000) were independent prognostic factors.

Conclusion

Patients with squamous cell carcinoma, early pathological T or N stage, or receiving chemotherapy had a more favorable prognosis.
Over-expression of small ubiquitin-like modifier proteases 1 predicts chemo-sensitivity and poor survival in non-small cell lung cancer
Authors: Mu Juwei , Zuo Yong , Yang Wenjing , Chen Zhaoli , Liu Ziyuan , Tu Jun , Li Yan , Yuan Zuyang , Cheng Jinke , He Jie
Published: January 2024

Background

Non-small cell lung cancer (NSCLC) is one of the most common malignant tumors. Despite the advances in therapy over the years, its mortality remains high. The aim of this study was to evaluate the expression of small ubiquitin-like modifier (SUMO) proteases 1 (SENP1) in NSCLC tissues and its role in the regulation of vascular endothelial growth factor (VEGF) expression. We also investigated the association between the expression level of SENP1 and the clinicopathological features and survival of the patients.

Methods

A SENP1 small interfering RNA (siRNA) was constructed and transfected into the NSCLC cells.VEGFgene expression was analyzed by real-time polymerase chain reaction (RT-PCR). Immunohistochemistry staining was used to assess the expression of SENP1 in 100 NSCLC patients and its association with the clinicopathological features and survival was analyzed.

Results

VEGF expression was significantly higher in NSCLC tissues than in normal lung tissues. Inhibition of SENP1 by siRNA was associated with decreased VEGF expression. SENP1 was over-expressed in 55 of the 100 NSCLC samples (55%) and was associated with a moderate and low histological tumor grade (3.6%, 38.2%, and 58.2% in high, moderate and low differentiated tumors, respectively,P=0.046), higher T stage (10.9% in T1, and 89.1% in T2 and T3 tumor samples,P<0.001) and TNM stage (10.9% in stage I, and 89.1% in stages II and III tumor samples,P<0.001). The rate of lymph node metastasis was significantly higher in the SENP1 over-expression group (76.4%) than that in the SENP1 low expression group (33.3%,P<0.001). Sixty three patients received postoperative chemotherapy, including 34 with SENP1 over-expression and 29 with SENP1 low expression. Among the 34 patients with SENP1 over-expression, 22 (64.7%) patients developed recurrence or metastasis, significantly higher than those in the low expression group 27.6% (8/29) (P=0.005). Multivariate Cox regression analysis showed that lymph node metastasis (P=0.015), TNM stage (P=0.001), and SENP1 expression level (P=0.002) were independent prognostic factors for the survival of NSCLC patients.

Conclusions

SENP1 may be a promising predictor of survival, a predictive factor of chemo-sensitivity for NSCLC patients, and potentially a desirable drug target for lung carcinoma target therapy.
Ability of lower teardrop edge to restore anatomical hip center height in total hip arthroplasty
Authors: Lu Yufeng , Cheng Liming , Guo Wanshou , Yu Qingsheng , Gao Fuqiang , Zhang Qidong , Liu Zhaohui , Sun Wei , Shi Zhencai
Published: January 2024

Background

The acetabular teardrop is often used to guide acetabular component placement in total hip arthroplasty (THA). Placing the lower acetabular component aspect at the same level as the lower teardrop edge was assumed to restore the hip center of rotation. Here we radiographically analyzed the relationship between cup center and normal contralateral acetabulum center height on unilateral THA using this placement method.

Methods

A total of 106 unilateral THA cases with normal contralateral acetabula were reviewed and the vertical and horizontal distances in relation to the lower acetabular teardrop edge from both hip joint centers, cup inclination, and anteversion were measured radiographically. The paired t-test was used to compare left and right hip center heights. Scatter plots and Pearson's correlation coefficients were used to evaluate differences in hip center heights, cup anteversion, inclination angles, and medialized cup center distance compared to the contralateral hip joint.

Results

Cup center height was significantly greater (P <0.01) than contralateral hip joint center height (93.4% in the 0–5 mm range, 6.6% >5 mm). There was a weak correlation between hip center height difference and inclination (r=0.376, P <0.01) and between difference and anteversion (r=0.310, P <0.01) but no correlation between difference and outer cup diameter (r=0.184, P=0.058) or difference and medialized cup center distance (r=-0.098, P=0.318).

Conclusions

Although this method did not exactly replicate anatomic hip center height, the clinical significance of cup center height and anatomic hip center height differences is negligible. This acetabular component placement method has high simplicity, reliability, and stability.
New disease severity classification of patients with stable chronic obstructive pulmonary disease in Shanghai
Authors: Guogang Xie , Yingying Zhang , Xin Zhou
Published: January 2024

Background

The Global Initiative for Chronic Obstructive Lung Disease (GOLD) presented a new ABCD group classification of chronic obstructive pulmonary disease (COPD). We aimed to examine the association of spirometric classification and the new GOLD classification with exacerbations, and to compare symptoms in different ways.

Methods

We investigated 848 patients with stable COPD from 24 hospitals. The annual frequencies of acute exacerbation and hospitalization were compared between the old and new classification. The symptom level was assessed using COPD assessment test (CAT) and modified British Medical Research Council (mMRC) questionnaire.

Results

A total of 848 patients were included in this study. According to spirometric classification, there were 32 patients of grade I (3.8%), 315 of grade II (37.1%), 366 of grade III (43.2%), and 135 of grade IV (15.9%). According to GOLD 2011 classification, there were 59 patients of group A (7.0%), 172 of group B (20.3%), 55 of group C (6.5%), and 562 of group D (66.3%). In spirometric classification, the annual frequencies of acute exacerbation and associated hospitalization were respectively 1 (0–3) and 0 (0–2) for grade I; 1 (0–5) and 0 (0–2) for grade II; 2 (0–6) and 1 (0–3) for grade III, and 3 (0–6) and 2 (0–3) for grade IV. In GOLD 2011, respectively 0 (0–3) and 0 (0–1) (group A), 1 (0–4) and 0 (0–3) (group B), 1 (0–5) and 0 (0–3) (group C), and 3 (0–6) and 1 (0–3) (group D). There were no significant difference between group B and C (Z= -1.347, P=0.178; Z= -0.772, P=0.440, respectively). The coincidence rate using mMRC=1 and CAT=10 as cutoff points was 86.6% (734/848, κ=0.706), compared with 77.9% (661/848, κ=0.60) using mMRC=2 and CAT=10.

Conclusions

Lung function test may be a better predictor of acute exacerbation and associated hospitalization of COPD. It is more appropriate to use mMRC=1 as cutoff point for assessing COPD symptoms.
Overexpression of glucosylceramide synthase and its significance in the clinical outcome of non-small cell lung cancer
Authors: Caiqing Zhang , Xiaoyan Lin , Yinghua Song , Xiaofang Zhang , Hongjia Li , Qiangxiu Wang
Published: January 2024

Background

Glucosylceramide synthase (GCS), an enzyme responsible for ceramide glycosylation, plays an important role in multidrug resistance (MDR) in some tumorsin vitro; however, its expression and clinicopathological significance in non-small cell lung cancer (NSCLC) remains unclear.

Methods

We evaluated GCS expression in 116 paired tumor and adjacent non-cancerous tissues and 50 frozen tissues from patients with NSCLC using immunohistochemistry and western blotting, and explored the correlation between GCS and NSCLC clinicopathological characteristics and prognosis. We observed the association between GCS and the MDR proteins P-glycoprotein (P-gp) and lung resistance-related protein (LRP) to determine the link between GCS and MDR at the histological level.

Results

GCS expression was significantly upregulated in NSCLC tumors compared with non-cancerous tissue. There was high GCS expression in 75/116 tumor specimens (64.7%) and 16/116 non-cancerous specimens (13.8%). High GCS expression was significantly associated with poor differentiation (P=0.01), lymph node metastasis (P=0.004), recurrence/ distant metastasis (P=0.006), and chemotherapy resistance (P=0.025). Multivariate analysis demonstrated that GCS immunopositivity was an independent risk factor for survival (P=0.018). P-gp was expressed in 80/116 tumors (69.0%) and in 12/116 non-cancerous tissue specimens (10.3%;P=0.001); LRP was expressed in 85/116 tumors (73.3%) and 19/116 non-cancerous tissue specimens (16.4%;P=0.001). Importantly, the results demonstrated that increased GCS expression in NSCLC cancer specimens correlated with increased expression of P-gp and LRP, molecules known to stimulate cancer cell MDR (r=0.612 and 0.503,P=0.01 and 0.035, respectively).

Conclusion

GCS upregulation might contribute to the development of NSCLC and could be a useful prognostic indicator and chemoresistance predictor for NSCLC patients.
Interaction of sleep quality and sleep duration on glycemic control in patients with type 2 diabetes mellitus
Authors: Yunzhao Tang , lingling Meng , Daiqing Li , Min Yang , Yanjuan Zhu , Chenguang Li , Zhenhuan Jiang , Ping Yu , Zhu Li , Hongna Song , Changlin Ni
Published: January 2024

Background

Copious evidence from epidemiological and laboratory studies has revealed that sleep status is associated with glucose intolerance, insulin resistance, thus increasing the risk of developing type 2 diabetes. The aim of this study was to reveal the interaction of sleep quality and sleep quantity on glycemic control in patients with type 2 diabetes mellitus.

Methods

From May 2013 to May 2014, a total of 551 type 2 diabetes patients in Tianjin Metabolic Diseases Hospital were enrolled. Blood samples were taken to measure glycosylated hemoglobin (HbA1c), and all the patients completed the Chinese version of the Pittsburgh Sleep Quality Index (PSQI) questionnaire to evaluate their sleep status. “Good sleep quality” was defined as PQSI <5, “average sleep quality” was defined as PQSI 6–8, and “poor sleep quality” was defined as PQSI >8. Poor glycemic control was defined as HbA1c ≥7%. Sleep quantity was categorized as <6, 6–8, and >8 hours/night. Short sleep time was defined as sleep duration <6 hours/night.

Results

In the poor glycemic control group, the rate of patients who had insufficient sleep was much higher than that in the other group (χ2=11.16, P=0.037). The rate of poor sleep quality in poor glycemic control group was much greater than that in the average control group (χ2=9.79, P=0.007). After adjusted by gender, age, body mass index, and disease duration, the adjusted PSQI score's OR was 1.048 (95% CI 1.007–1.092, P=0.023) for HbA1c level. The sleep duration's OR was 0.464 (95% CI 0.236–0.912, P=0.026) for HbA1c level. One-way analysis of variance showed that the poor sleep quality group had the highest homeostasis model assessment-insulin resistance (P <0.01).

Conclusions

Inadequate sleep, in both quality and quantity, should be regarded as a plausible risk factor for glycemic control in type 2 diabetes. Poor sleep might bring much more serious insulin resistance and could be the reason for bad glycemic control. A good night's sleep should be seen as a critical health component tool in the prevention and treatment of type 2 diabetes. It is important for clinicians to target the root causes of short sleep duration and/or poor sleep quality.
Virus profile in children with acute respiratory infections with various severities in Beijing, China
Authors: Zhu Runan , Song Qinwei , Qian Yuan , Zhao Linqing , Deng Jie , Wang Fang , Sun Yu
Published: January 2024

Background

Acute respiratory infection (ARI) is one of the most common infectious diseases in infants and young children globally. This study aimed to determine the virus profile in children with ARI presenting with different severities.

Methods

Clinical specimens collected from children with ARI in Beijing from September 2010 to March 2011 were investigated for 18 respiratory viruses using an xTAG Respiratory Viral Panel Fast (RVP Fast) assay. The Pearson chi-square analysis was used to identify statistical significance.

Results

Of 270 cases from three groups of ARI patients, including Out-patients, In-patients and patients in the intensive care unit (ICU), viruses were detected in 176 (65.2%) specimens with the RVP Fast assay. The viral detection rate from the Out-patients group (50.0%) was significantly lower than that from the In-patients (71.1%) and ICU-patients (74.4%) groups. The virus distribution was different between the Out-patients group and the other hospitalized groups, while the virus detection rate and distribution characteristics were similar between the In-patients and ICU-patients groups. The co-infection rates of the Out-patients group, the In-patients group, and the ICU-patients group were 15.6%, 50.0% and 35.8%, respectively. In addition to respiratory syncytial virus (RSV) and adenovirus (ADV), human rhinovirus (HRV) was frequently detected from children with serious illnesses, followed by human metapneumovirus (hMPV), human bocavirus (HBoV) and coronaviruses. Parainfluenza virus 3 (PIV3) was detected in children with lower respiratory illness, but rarely from those with serious illnesses in the ICU-patient group.

Conclusion

In addition to so-called common respiratory viruses, virus detection in children with ARI should include those thought to be uncommon respiratory viruses, especially when there are severe ARI-related clinical illnesses.
Proximal gastric cancer: lymph node metastatic patterns according to different T stages dictate surgical approach
Authors: Song Wu , Liu Yuyi , Ye Jinning , Peng Jianjun , He Weiling , Chen Jianhui , Chen Chuangqi , He Yulong
Published: January 2024

Background

As a common form of gastric cancer migration, lymph node metastasis largely affects the surgical treatment and prognosis of gastric cancer. Surgery is the fundamental curative option for gastric cancer that varies depending on different stages. The study aimed to compare the clinicopathological characteristics and lymph node metastatic patterns in patients of proximal gastric cancer with different T stages and investigate a reasonable radical gastrectomy approach in terms of the range of lymphadenectomy for proximal gastric cancer.

Methods

In our retrospective study, the data of 328 patients of proximal gastric cancer with different T stages were analyzed. By comparing the differences of lymph node metastatic rate and ratio, we investigated the clinicopathological characteristics and metastatic patterns of lymph nodes. Also, we were especially interested in the differences in survival rates between patients with and without No. 5 and 6 group metastasis with the same TNM stage.

Results

The overall lymph node metastatic rate and ratio of advanced proximal gastric cancer were 73.4% and 23.3%, respectively. The tumors of different T stages were statistically significant in size and differentiation degree (P <0.05), multivariate analysis showed that the depth of tumor invasion was an independent risk factor for lymph node metastasis in proximal gastric cancer (RR, 12.025; 95% CI, 2.326 to 62.157; P=0.003). The overall survival rate of patients with No. 5, 6 group lymph node metastasis and those without was significantly different, but the differences in survival rates between patients with and without No. 5 and 6 group metastasis with the same TNM stage were not statistically significant.

Conclusions

Different T stages in proximal gastric cancer showed different patterns and characteristics of lymph node metastasis. D2 lymphadenectomy in patients with early gastric cancer had little survival benefit because metastasis to level 2 nodes was rare. Therefore the range of the lymph node dissection in radical gastrectomy for early gastric cancer was considered reasonable. Moreover, to meet the requirements of the lymph node dissection, total gastrectomy plus D2 lymphadenectomy or more are supposed to be applied for the advanced proximal gastric cancer patients. Precise T staging largely determines the range of gastrectomy and lymphadenectomy.
Incidence and risk factors analysis of heterotopic ossification after cervical disc replacement
Authors: Qi Min , Chen Huajiang , Cao Peng , Tian Ye , Yuan Wen
Published: January 2024

Background

Cervical disc replacement (CDR) as a substitute for traditional fusion surgery has been widely used in treating degenerative cervical disc diseases. The objectives of this study were to assess the clinical and radiological findings for patients with heterotopic ossification (HO) following CDR and to detect the risk factors of HO after CDR.

Methods

A total of 125 patients with symptomatic cervical single- or double-level disc diseases, who underwent CDR procedure with Discover prosthesis in Department of Spine Surgery, Changzheng Orthopedics Hospital from March 2009 to March 2011, were enrolled in this retrospective study. Occurrence of HO was defined by the McAfee classification on cervical lateral X-rays in this study. Prosthesis vertebral ratio (PVR) was used to determine the matching degree between the cervical disc prosthesis and cervical vertebra. Logistic regression analyses were performed to determine the risk factors of HO. Variables evaluated for their association with HO occurrence included age, gender, high-intensity signal in spinal cord, preoperative range of motion (ROM), postoperative ROM, operation level number, and PVR.

Results

Mean follow-up time was (26.4±5.8) months. All the patients had significant symptoms and neurological function improvements during the follow-up period. The ROM of the operated segment from the preoperative period to the last follow-up was relatively well maintained. The rate of HO in this cohort of patients, who underwent Discover disc, was 27.92% per surgical level and 24.8% per patient by the last follow-up. There were 19 patients (19.79%) with HO in the single-level group while 12 patients (41.38%) in the double-level group.

Conclusions

We identified preoperative high-intensity signal in spinal cord, postoperative ROM of surgical level, number of operation level, and PVR as significant risk factors for postoperative HO occurrence.
Pelatihan Perancangan Dekorasi Motif Kerudung Dengan Aplikasi Surface Design Mix Material Embellishment
Authors: Siagian Marissa Cory , Sekar Fardhani Ahda Yunia , Takao Gina Shobiro
Published: January 2024

Berkembangnya industri Muslim Indonesia hal tersebut terlihat dari berkembangnya trend fashion dan industry khususnya busana Muslim lahir dari local brand Indonesia. Perkembangan ini tidak terlepas dari sumber daya manusia yang terlibat, maka diperlukan upaya pengembangan wawasan dan kemampuan ketrampilan sumber daya manusianya sehingga meningkatkan kompetensi yang dimiliki, khususnya membangun potensi anak muda Indonesia.

Dalam kegiatan pengabdian masyarakat ini kami melihat adanya potensi pengembangan keahlian kepada beberapa anak muda khususnya para santri dan masyarakat Pesantren Sirojul Huda Parung- Serab, Soreang, Jawa Barat. Dengan berbekal kemampuan menjahit dasar, fasilitas mesin jahit, perlu pengembangan keterampilan dalam menciptakan produk yang berkaitan dengan kebutuhan berbusana Muslim berupa pengembangan kerudung yang sesuai dengan trend fashion busana Muslim saat ini. Pelatihan yang diharapkan kedepannya para santri dan masyarakat sekitarnya dapat ikut menjadi pelaku industri Busana Muslim Indonesia. Pelatihan ini berupa pendampingan transfer ilmu dengan memberikan pengetahuan, keterampilan berupa wawasan teknik elemen dan material dekorasi Teknik kriya desain kerudung sesuai dengan trend saat ini. Besar harapan dengan kegiatan ini potensi, keterampilan dan pengetahuan masyarakat sasar sekitar berkembang dan dapat diimplementasikan dalam indutri Muslim sehingga   kedepannya mendapat pekerjaan layak serta peningkatan ekonomi baik bekerja berkemlompok maupun individual baik indutri kecil maupun garmen.

 

Kata kunci: Busana Muslim, Kerudung, Trend.
Comparación de los Factores de Riesgo para Complicaciones por Covid en Personal de la Unidad de Medicina Familiar No. 73
Authors: León Cardona Esteban , Rodríguez Campos Pedro Alberto , Delgado Hernández Massiel Alejandra
Published: January 2024

Antecedentes: El COVID 19 es una enfermedad que afecta las vías respiratorias generando patrones restrictivos en la ventilación los cuales se agravan ante la presencia de determinados factores de riesgo relacionados con el mal pronóstico de la infección tales como obesidad y sobre peso, edad mayor a 60 años, diabetes e hipertensión en descontrol, enfermedades que generan inmunocompromiso, embarazo o lactancia. Objetivo: Analizar la diferencia en los factores de riesgo para complicaciones por COVID presentes en el personal de la Unidad de Medicina Familiar No. 73 en el 2021 con respecto a 2020. Material y métodos: Se realizó un estudio observacional, comparativo y longitudinal en trabajadores de la Unidad de Medicina Familiar No. 73 del IMSS, delegación Coahuila, 291 sujetos contestaron la encuesta EPICAVT; se realizó estadística descriptiva y comparativa con Chi2 con nivel de confianza al 95% y valor de p≤0.05. Resultados y conclusiones: Se formaron 2 grupos de estudio según el año de aplicación de la encuesta, se encontró diferencia estadística entre ambos grupos en variables como: sexo, escolaridad y presencia de antecedentes patológicos; además esta diferencia entre grupos también se observó en los valores de edad, IMC, presión arterial, glucosa, triglicéridos y colesterol (p≤0.05). La diferencia de los factores de riesgo para complicaciones por COVID en los grupos de estudio fue diferente, el grupo encuestado en 2021 presentó menos factores de riesgo como patologías diagnosticadas y valores más bajos en los exámenes de laboratorio con respecto al grupo de 2020.
Fortalecimiento del Pensamiento Matemático y la Lectura Crítica para la Resolución de Problemas Multiplicativos a Través de Estrategias Didácticas en Estudiantes de Quinto Grado
Authors: Alvarado Guerra Pedro Harly
Published: January 2024

En el presente artículo de investigación científica, cuyo objetivo general consiste en el desarrollo de una propuesta pedagógica encaminada a fortalecer el pensamiento matemático y la lectura crítica para la solución de problemas multiplicativos, a través de la implementación de estrategias didácticas en estudiantes del grado 5° de la escuela primaria El centro Educativo Rural Santa Rita, en el municipio de Sopetrán, se basó en el uso de Recursos Educativos Digitales Abiertos (REDA), tomando en cuenta contextos internacionales, nacionales y locales. Este proyecto es correlacional, enmarcado en el enfoque cuantitativo, con un diseño preexperimental, con un grupo control, estudiando una población de 30 estudiantes, utilizando instrumentos como la ficha de inscripción, el pretest y el postest, análisis estadístico del pretest resultando en las deficiencias de los estudiantes en el nivel de comprensión lectora crítica. Lo anterior permitió estructurar una propuesta pedagógica basada en Tecnologías de la Información y las Comunicaciones (TIC), para mejorar estos niveles de desempeño, dado que los resultados estadísticos de la prueba muestran mejores promedios por parte de los estudiantes donde se implementaron las estrategias pedagógicas. Además, la verificación de la hipótesis mediante la prueba de rangos de Wilcoxon, una estadística no paramétrica, confirma la importancia del uso de recursos educativos digitales en los procesos de enseñanza y aprendizaje. Lo anterior demuestra que la integración de las Tecnologías de la Información y las Comunicaciones (TIC) en el área de las matemáticas representa una estrategia pedagógica efectiva para potenciar el rendimiento académico de los estudiantes. Por lo tanto, el proyecto cumplió satisfactoriamente con su objetivo general.
La Inactividad Física como Predictor de Obesidad Abdominal en la Población Adulta
Authors: Fernández Viviana Cristina , Valdéz Nathalia , González de Lamas Alma , De Sousa Filho Girnaldo Leónidas , Armando Meza Gustavo , Chaux Alcides
Published: January 2024

Este estudio investiga la relación entre la actividad física y la obesidad abdominal en adultos de 30 a 60 años en Ciudad del Este. Adoptando un enfoque cuantitativo, observacional y descriptivo, se analizaron datos de 84 participantes, con un predominio femenino del 80%. La investigación reveló una alarmante prevalencia de baja actividad física, con más del 90% de los participantes reportando niveles bajos. Además, la mayoría presentó valores altos de circunferencia abdominal, indicativos de obesidad abdominal, especialmente en mujeres. Estos hallazgos resaltan una correlación significativa entre la inactividad física y la obesidad abdominal, un problema que se refleja en diversas poblaciones. La comparación con estudios similares subraya la universalidad de este desafío de salud pública. La prevalencia de inactividad física y su asociación con la obesidad abdominal enfatizan la necesidad de intervenciones para mejorar los niveles de actividad física. En conclusión, este estudio aporta evidencia crucial para la planificación de políticas de salud y programas de intervención enfocados en promover estilos de vida activos y saludables. Destaca la importancia de desarrollar estrategias que fomenten la actividad física y aborden barreras culturales y sociales, especialmente entre los hombres, para combatir la obesidad abdominal y prevenir enfermedades crónicas relacionadas.
Küçük Kaynarca Sonrası Osmanlı-Rus Müzakerelerinden Bir Kesit: 1776 Tarihli Mükâleme Belgesi
Authors: Ünlü Ertan
Published: January 2024

1768-1774 Osmanlı Rus Savaşı, sonuçları açısından Osmanlı İmparatorluğu için bir dönüm noktasıdır. Çünkü 21 Temmuz 1774’te imzalanan Küçük Kaynarca Antlaşması, Kırım’ın bağımsızlığı ve Osmanlı İmparatorluğu’nun savaş tazminatı ödemesi gibi ağır şartlar barındırmaktadır. Bu bağlamda Küçük Kaynarca Antlaşması, her ne kadar iki devlet arasındaki savaşı bitirmiş olsa da içerdiği belirsizliklerle yeni sorunların çıkmasına temel teşkil etmiştir. Zira Rusya, antlaşmayı gerekçe göstererek, İstanbul dışında konsolosluk açma, Karadeniz’de Osmanlı aleyhine ticari faaliyet yürütme, Kırım’ı ilhaka yönelme gibi çeşitli girişimlerde bulunmuştur. Bu nedenle iki devlet beynindeki sular, Küçük Kaynarca sonrasında bir türlü durulmamıştır. Bu da Osmanlı İmparatorluğu ile Rusya arasında Aynalıkavak Tenkihnamesi’ne kadar devam eden yoğun bir müzakere sürecine yol açmıştır.

Burada neşrettiğimiz ve Osmanlı Arşivi’nde Yıldız Esas Evrakı tasnifi içinde 91/44 numara ile kayıtlı olan mükâleme belgesi de bu sürecin bir ürünüdür. Bu belge, Küçük Kaynarca Antlaşması sonrasında Osmanlı İmparatorluğu ile Rusya arasındaki ilişkiler açısından önem arz etmektedir. İlgili belge, Reisülküttap Raif İsmail Efendi’nin Rusya orta elçisi Aleksandr Stachieviç Stachiev’le Kuzguncuk’taki yalısında 7 Mayıs 1776’daki görüşmesinde yönelttiği on iki maddelik sorular temelinde şekillenmiştir. Bu sorular, reayanın durumu, kiliseler, tazminat ödemeleri, Tatarların durumu gibi konular hakkındadır. Fakat Stachiev devletine danışması gerektiğinden, Raif İsmail Efendi’ye hemen cevap verememiştir. Dolayısıyla Rusya’dan beklenen yanıt ancak 15 Eylül 1776’da gelmiştir.
Çukurova Âyânları IV: Hasanpaşazâde Ahmet Bey II
Authors: Kurt Yılmaz
Published: January 2024

18. Yüzyıl Çukurova’da âyânlığın en güçlü olduğu yıllardır. Adana valilerinin Rumeli’de bulunan kale ve şehirlerin korunması için görevlendirilmiş olması, şehirlerin mütesellimler eliyle yönetilmesi sonucunu doğurdu. İşte bölgenin güçlü âyân ailesi Karslızâdeler veya daha sonraki adıyla Hasanpaşazâdeler 1750 yılından sonra böyle bir tablo içerisinde ortaya çıkmış ve bölgenin yönetiminde etkili olmuştu. 1770 yılında Karslızâde Hasan Paşa’nın Üzeyir sancakbeyi olarak atanmasından sonra aile, Hasanpaşazâdeler olarak anılmaya başlamıştır. Hasanpaşazadeler, Adana Müftüsü İshak Efendi üzerinden Ramazanoğulları kimliği ile Cumhuriyete intikal etmiş köklü bir âyân ailesidir.

Hasanpaşazâdeler âyân ailesi ve bu ailenin en güçlü ismi Ahmet Bey hakkında bugüne kadar bazı akademik yayınlar yapılmıştır. 1793-1811 yılları arasında birçok defa Adana mütesellimliği yapan Ahmet Bey hakkında, gerek Adana Şer’iye Sicillerinde ve gerekse diğer Osmanlı Arşiv kaynaklarında yüzlerce belge bulunmaktadır. 57 numaralı Adana Şer’iye Sicili neredeyse tamamen Ahmet Bey ile ilgilidir. Bu belgeler sadece Çukurova bölge tarihi ve âyânlık mücadeleleri ile ilgili olmayıp Nizâm-ı Cedîd uygulamaları ve mâlikâne-mukataa işletmelerinin nasıl yürütüldüğü konusunda da değerli bilgiler sunmaktadır. Bundan önceki makalemizde Ahmet Bey’in mütesellimliğe atanması konusunda gerekli bilgiler verilmiş olduğundan biz burada yayınlamış olduğumuz belgelerin değerlendirilmesine ağırlık vermek istiyoruz.

Buraya aldığımız 71 belge Hasanpaşazâde Ahmet Bey’in 1798 yılından1802 yılına kadar olan mütesellimlik dönemlerine ilişkin belgelerdir. Bu dönem, Napolyon’un Mısır saldırısı yılları olduğundan yayınlanan belgeler bu savaşın arka planı konusunda çok kıymetli bilgiler sunmaktadır. Adana’da âyân ailelerinin mukataa ve malikâneleri nasıl ele geçirdiğini ve bu yolla bölgedeki hakimiyetlerini nasıl güçlendirdiklerini gösteren birçok belge araştırmacılara ulaştırılmış olmaktadır[1] .
İstanbul ve Çevresinde Veba-yı Bakari (1886-1891)
Authors: Tan Seda
Published: January 2024

Sığır vebası, en eski hayvan hastalıklarındandır. En çok, hassas türler olan sığır ve mandalara etki ettiği bilinir. Bulaşıcılığı ve ölüm oranı çok yüksek olan hastalık Anadolu coğrafyasında çağlar boyunca çok sayıda kırıma neden olduktan sonra ancak Cumhuriyet devrinde etkeni ile birlikte ortadan kaldırılabilmiştir. Anadolu tarihinin en uzun ve önemli kesitlerinden birisini temsil eden Osmanlılar devri boyunca ise hayvan varlığıyla sağlığını tehdit eden hastalıkların başında yer almıştır. Buna karşılık akademik literatürde diğer hayvan hastalıklarıyla birlikte insan hastalıklarının gölgesindedir. Hâlbuki hane ekonomisinin çift hayvanlarına dayandığı tarım odaklı ekonomilerde başta sığır vebası olmak üzere salgın hayvan hastalıkları, yalnız hayvan varlığı ve gönenciyle değil, sosyoekonomik hayatın bütünüyle ilgili deneyimlerdir. İnsan refahı ile şehirlerin huzur ve güvenliği bu travmatik deneyimden bağımsız düşünülemez.

Ele alınan çalışma hayvan mobilitesinin görece arttığı bir dönemde, Osmanlı sosyoekonomik hayatının istikrarı bakımından belirgin bir tehdit oluşturan ve Osmanlı İmparatorluğunun kalbi niteliğindeki başkentinde meydana gelen büyük bir sığır vebası salgınına odaklanmaktadır. 1886-1890, 1891 yıllarında en büyük tahribatını gerçekleştiren söz konusu salgın çalışmada yayılım coğrafyası, kronolojisi ve mücadele uygulamaları bağlamında değerlendirilmeye çalışılmıştır. Bu çerçevede kaynak, intikal, korunma/önleme gibi başlıklar çalışmanın odak noktalarını oluşturmuşlardır. Çalışmanın ana kaynağı ise birinci el kaynak niteliğindeki Osmanlı arşiv vesikalarıdır. Makale, dönemi ve hastalığın tarihçesini konu edinen doğrudan ve dolaylı diğer literatürle de desteklenmiştir.
Rumeli Vilayetlerinde Mülkiye Müfettişliği (1896-1902)
Authors: Sarı Mustafa , Yavuz Fikrettin
Published: January 2024

Osmanlı Devleti’nde teftiş uygulaması modern anlamda Tanzimat Dönemi ile başlamıştır. Mülkiye müfettişliği ise 1877-1878 Osmanlı-Rus Savaşı’ndan sonra imzalanan Berlin Antlaşması’nın hükümlerinin yerine getirilmesi için yapılan Rumeli Islahatları çerçevesinde 1896 yılında oluşturulmuştur. Mülkiye müfettişlerinin vazifeleri ile görev tanımını belirlemek için aynı yıl bir talimatname yayınlanmıştır. Bu talimatnameye göre mülkiye müfettişleri en geniş anlamıyla mülkiye memurlarının kanun ve yasalara uygun hareket edip etmediklerini teftiş edeceklerdi. Mülkiye müfettişliğinin bu ilk uygulamasında Anadolu dışarıda kalmış ve sadece altı Rumeli vilayeti kapsam dâhiline alınmıştır. Bunun önemli sebeplerinden biri Osmanlı’nın son döneminde krizin eksik olmadığı Rumeli’de asayiş ve güvenliğin sağlanması hedefiydi. Bu doğrultuda 1896 yılından 1902 yılına kadar altı yıl boyunca mülkiye müfettişleri Rumeli vilayetlerinde görevleri icabı teftişlerde bulunmuşlardır. Merkezi yönetim ve bilhassa II. Abdülhamid mülkiye müfettişlerine büyük önem verse de başta valiler olmak üzere yerel makamlar ile mülkiye müfettişleri arasında başlangıcından itibaren bazen birbirlerini merkeze şikâyet edecek boyutlara ulaşan problemler ve anlaşmazlıklar meydana gelince nihayet 1902 yılında bu uygulamadan vazgeçilmiştir. Bu çalışmada öncelikle Cumhurbaşkanlığı Osmanlı Arşiv belgeleri kullanılarak 1896-1902 yılları arasında mülkiye müfettişliği teşkilatının kurulması, müfettişlik talimatnamesinin değerlendirilmesi, müfettişlerin atanma süreçleri ile görev yerlerinde karşılaştıkları sorunların ele alınması hedeflenmiştir. Çalışmanın temel gayesi Osmanlı Devleti’ndeki bu ilk mülkiye müfettişliği tecrübesinin analiz edilmesidir.
Xueyantuoların Kökenleri ve Tarihlerindeki Boşluklar
Authors: Yavrucuk Gökay
Published: January 2024

Friedrich Hirth’in Çin kaynaklarındaki Xueyanuo’nun Sir Tarduş olduğu fikri kısa süre için genel kabul gördüyse de sonraki araştırmalar başka sonuçlar ortaya çıkarmıştır. Hirth, Xue’nin Tonyukuk Yazıtı’ndaki Sir olduğundan emin olmakla birlikte, Yantuo’nun Tarduş olduğunu kanıtlayamamıştır. Tongdian’ın Yantuoları Helanlarla özdeşleştirmesi yeni araştırmalara yön vermiştir. Araştırmacılar Helan ve Yantuo kelimelerinin Türkçe karşılıklarına odaklanmış ve Yantuo’nun Tarduş olmadığı kanıtlanmıştır. Fakat Yantuoların tarihleri devamlılık içinde aydınlatılamamış, büyük boşluklar kalmıştır. Diğer Yandan Xue’nin anlamı ve Xuelerin tarihi üzerinde durulmamıştır. Bu çalışmada Tongdian’ın kurduğu Hela-Helan-Yantuo özdeşliği sorgulanmıştır. Yantuo ismi kaynaklarda ortaya çıkıncaya kadar Helanların vaziyetine dair kayıtlar araştırılmak suretiyle Yantuo tarihinin boşluklarının doldurulması için çalışılmış, Xuelerin kökenine ve Xueyantuo adının kaynaklarda belirmesine kadarki tarihlerine dair kayıtlar incelenerek Xuelerin Yantuoları ele geçirdiği tarihin tespit edilmesi hedeflenmiştir. Xueyantuo Kağanlığı’nın yıkılışından sonra Xueyantuo boyunun akıbeti sorgulanırken nihayet Tonyukuk Yazıtı’nda görülen Sir’in bir boy adı olarak Çin kaynaklarınca zikredilen Xue Boyu olup olmadığı incelenmiştir.
Osmanlı Devleti’nde Mahkûmların İmar ve İnşa Faaliyetlerinde İstihdamı (1840-1920)
Authors: Göktepe Kaya
Published: January 2024

Osmanlı Devleti’nde yenileşme süreci çeşitli alanlarda değişim ve dönüşüme sahne olmuş ve bu alanlardan birisini de sosyoekonomik hayat oluşturmuştur. Osmanlı sosyoekonomik hayatında yaşanan değişim ve dönüşüm süreciyle birlikte modern fiziki mekânlara ihtiyaç artmış ve bu durum, devletin alt ve üst yapı yatırımlarına daha fazla önem vermesini sağlamıştır. Tanzimat ve sonrasında ülkenin imar ve inşası bu gelişmelerle önem kazanmış olsa da ihtiyaca cevap verebilecek düzeyde iş gücü temininde zorluklar yaşanmıştır. Bunun sonucunda ihtiyaç duyuldukça geçmişten beri başvurulan alternatif iş gücü kaynakları önemli hâle gelmiş ve mahkûmlar da bu kaynaklar içerisinde yer almıştır. Osmanlı Devleti’nde mahkûm emeğine ilk olarak, XVI. yüzyılın ortalarında donanmada kürekçi adı altında başvurulmuş, ancak zamanla gemi teknolojisinin değişimi mahkûm emeği ihtiyacını azalttığı için mahkûmların iş gücü piyasasındaki rolü giderek düşmüştür. Osmanlı iş gücü piyasasında mahkûmların tekrar önem kazanması Tanzimat Dönemi’yle gerçekleşmiş ve bunun arka planında da özellikle hukuki ve iktisadi faktörler belirleyici olmuştur. Bu kapsamda dönem içerisinde yeni ceza kanunlarında kürek ve pranga cezasının ayrıntılı şekilde yer bulması, kürek ve pranga cezasına hükmedilenlerin sayısını arttırmıştır. Diğer taraftan bu dönemde devletin içinde bulunduğu olumsuz mali koşullar ve acil iş gücü ihtiyacı ise kürek ve pranga mahkûmlarının niteliksiz iş gücü ihtiyacının en fazla hissedildiği alanlardan birisi olan imar ve inşa faaliyetlerinde istihdam edilmesini olanaklı hâle getirmiştir. İhtiyaç hasıl oldukça başvurulan bu uygulama, daha sonra II. Meşrutiyet Dönemi’nde “serseri” olarak ifade edilen mahkûmları da içine alacak şekilde genişlemiştir. Nihayetinde bu tür gelişmeler ise imar ve inşa faaliyetlerinde mahkûm emeğinin daha da yaygınlaşmasını sağlamıştır.