bluuebunny/crossref_metadata_2025 huggingface dataset:
Silver Nanoparticle as a Modern Era in Antimicrobial Activity
Authors: I Shaikh Imran , Shafi Dr Sameer , Kazi Anis , Sante Rohini , Jadhav Avinash , Mohini Gurav , Ritthe Punam
Published: November 2024

In the modern era of antimicrobial research, silver nanoparticles (AgNPs) have emerged as promising agents with unprecedented potential. This abstract encapsulates the multifaceted role of silver nanoparticles in combating microbial threats. AgNPs exhibit unique physicochemical properties that contribute to their antimicrobial efficacy, including a high surface area-to-volume ratio and distinct electronic and optical behaviours. These characteristics enable diverse antimicrobial mechanisms, such as disrupting cell membranes, interfering with cellular processes, and inducing oxidative stress. Moreover, the size-dependent activities of AgNPs enhance their specificity against a broad spectrum of microorganisms, including bacteria, fungi, and viruses. The abstract delves into the diverse applications of silver nanoparticles in various fields, from healthcare to environmental protection. AgNPs have found utility in medical devices, wound dressings, and pharmaceutical formulations, showcasing their versatility in preventing and treating infections. Additionally, the abstract emphasizes the role of silver nanoparticles in water treatment and disinfection, underscoring their potential impact on public health. However, challenges such as cytotoxicity and environmental concerns warrant meticulous investigation and optimization in the design and application of AgNPs. The abstract concludes by acknowledging the imperative nature of ongoing research in unraveling the full potential of silver nanoparticles as a modern-era antimicrobial strategy, offering unprecedented solutions to combat the evolving challenges posed by microbial resistance in the contemporary world.
Ethnomedicinal and Cytotoxic Activities of Calotropis Procera-A Review
Authors: MA Brunda , MA Bindhu , Kumar BS Ashok , A Mouna , B Subhashini
Published: November 2024

Plants are major sources of drugs that we use today. One such plant is Calotropis procerawhich can be consider as a home for many phytochemicals. Each part of this plant is enriched with various phytochemicals having its own significance for human life. The phytochemistry of this plant reveals presence of triterpenoids, anthocyanins, flavonoids, cardiac glycosides, cardenolides, α– amyrin, β-myrin, lupeol, β-sitosterol, flavanols, mudarin, resin, a powerful bacteriolytic enzyme calactin, a non-toxic proteolytic enzyme calotropin. The plant exhibits antimicrobial, anthelmintic, anti-inflammatory, analgesic, antipyretic, anticancer, antiangiogenic, immunological, antidiabetic, cardio vascular, hypolipidemic, gastro protective, hepatoprotective, renal protective, antidiarrheal, anti-oxidant, anti-convulsant and wound healing effect. This review is an attempt to stack the phytochemical and pharmacological activities of Calotropis procera shrubs.
Review on Advancement in Cosmetic Science For Melasma
Authors: Adalinge Shravani Arvind , Adalinge Dr. Shruti.A. , Naikawadi Nishigandha. D. , Redasani Dr. V.K.
Published: November 2024

Melasma, a common hyperpigmentation disorder, poses a significant challenge in the field of dermatology and cosmetic science. Characterized by symmetrical, brownish facial pigmentation, melasma primarily affects women of reproductive age, with a notable impact on quality of life. Despite its prevalence, effective and long-lasting treatments remain elusive. This review explores the latest developments in cosmetic science aimed at addressing melasma, focusing on innovative formulations, ingredients, and technologies.Traditional and contemporary cosmetic approaches to melasma, including the use of topical agents such as hydroquinone, retinoids, and corticosteroids. Additionally, the review discusses emerging ingredients like tranexamic acid, niacinamide, kojic acid, and botanical extracts known for their skin-lightening properties.
The review concludes by emphasizing the need for a multifaceted approach in cosmetic science to effectively manage melasma. By combining traditional and novel ingredients, optimizing delivery systems, and integrating advanced technologies, cosmetic formulations can offer improved efficacy and patient satisfaction in the management of melasma. Future directions for research and development are also discussed, with an emphasis on personalized skincare regimens tailored to individual patient characteristics.
The Latest Advancements: A Comprehensive Review of Microballoons for Enhanced Gastroretention
Authors: Chavan Payal B. , Malpure Prashant S. , Talele Gokul S. , Kadam Abhishek R.
Published: November 2024

Because of their potential to remain in the gastric region for extended periods of time, gastro-retentive drug delivery methods hold great promise in oral treatment. This improves medication solubility, resulting in increased bioavailability and decreased drug waste. To achieve gastro-retentive qualities, various ways have been proposed, with microballoons in the form of hollow microspheres being a commonly investigated possibility. These microballoons, which are hollow spherical particles with no central core and have a size of less than 200 micrometers, provide an excellent method of managing medication release with site-specific absorption. Floating microballoons release via gastro-retentive mechanisms, effectively increasing bioavailability and providing a viable remedy for stomach retention. Hollow microspheres with optimized properties have the potential to revolutionize new drug delivery, particularly for secure, targeted, and efficient in vivo delivery. They represent a promising approach to gastric retention, reducing variability in plasma drug concentrations. This review provides insights into recent advances in formulation methods, evaluation techniques, the use of polymers in microballoons, and their applications as gastro-retentive drug delivery systems with controlled release capabilities.
Formulation and Evaluation of Delayed Release Coated Tablet of Dalfampridine for the Treatment of Multiple Sclerosis
Authors: Mhaskey Yukta K. , P. Wankhade Dr. Vikrant , Tikait Aditi V. , C. Atram Dr. Sandeep , Bobade Nishant N. , Pande Dr. S. D.
Published: November 2024

The study aimed to develop delayed release coated tablets of Dalfampridine for treating multiple sclerosis. Dalfampridine core tablets were prepared using wet granulation method with various excipients. Pre-compression parameters and flow characteristics were evaluated to ensure smooth tablet production. Post-compression studies included weight variation, thickness, hardness, friability, drug content, and In-vitro drug release. Coating was applied to the core table formulation using a 5% coating solution consisting of Eudragit L100-55, PEG-600, talc, color concentrate, IPA, and acetone. Coating parameters such as inlet temperature, spraying rate, and pan rotation were optimized using a 23 factorial design. The stability study confirmed the formulation's stability at room temperature and 40°C/75% RH for one month. The coated tablets showed no drug release in acidic environments (pH 1.2) but released the drug in intestinal environments (pH 6.8). Formulation E2, coated under specific conditions i.e. inlet temperature of 500c, spay rate of 2ml/min and pan rotation of 15 rpm was identified as the best formulation based on % weight gain, coating process efficiency, and release time in the intestine.
Environmental Toxins and Microplastics: An In-Depth Comparative Analysis of Subtle Health Hazards"
Authors: Ameya Lanjewar
Published: November 2024

This study aims to comprehensively investigate the combined toxicity of microplastics and heavy metals, with a focus on their impact on human health and the ecosystem. The research specifically explores the risks associated with ingesting microplastics containing elevated levels of heavy metals, examining their potential contribution to diseases such as cancer, reproductive disorders, neurological diseases, cardiovascular conditions, respiratory ailments, and diabetes.
An exhaustive literature review synthesizes existing evidence on the individual and synergistic effects of microplastics and heavy metals. This review includes studies on the absorption of heavy metals by microplastics and their influence on human health, particularly role in diseases such as cancer, reproductive disorders, neurological diseases, cardiovascular conditions, respiratory ailments, and diabetes.  Microplastics may exacerbate heavy metal absorption into the bloodstream through damage to the gut lining.
Current research findings underscore the escalating concern for public health due to the combined toxicity of microplastics and heavy metals. Microplastics have been found to absorb heavy metals, potentially leading to elevated concentrations when ingested. Damage inflicted by microplastics on the gut lining may contribute to an increased risk of diseases, including cancer, reproductive disorders, neurological diseases, cardiovascular conditions, respiratory ailments, and diabetes.
 
The observed combined toxicity poses a serious and multifaceted threat to both human health and the ecosystem. Urgent action is imperative to mitigate exposure and implement sustainable practices. The existing evidence highlights the critical need for further research to comprehend the intricate risks associated with the interaction between microplastics and heavy metals, emphasizing the urgency of addressing this emerging public health concern, including its link to diabetes.
Preparation and Evaluation of In-Situ Gel from the Root Extract of Boerhaavia Diffusa in the Treatment of Cataract
Authors: Lanjewar Kalyani , Telgote Sachi , Shirpurkar Avantika
Published: November 2024

Cataract remains a significant global health issue, necessitating innovative treatment approaches. This study explores the formulation of an in-situ gel derived from the roots of Boerhaavia diffusa for potential cataract therapy. Boerhaavia diffusa, renowned for its pharmacological properties, offers a promising natural source for ocular drug delivery. The gel formulation is designed to provide sustained drug release and enhanced bioavailability, addressing the limitations of conventional treatments. The preparation method involves extraction of bioactive compounds from Boerhaavia diffusa roots, followed by formulation into a thermo-sensitive in-situ gel using suitable polymers.The roots of Boerhaavia diffusa were collected, washed, and dried before extraction using a suitable solvent system. The obtained extract was then evaluated for its phytochemical composition, including alkaloids, Glycosides, tannin, terpenoid and Saponins, through standard qualitative and quantitative methods.The in-situ gel formulation was prepared using the obtained extract and suitable gelling agents. Various physicochemical parameters of the gel, such as pH, viscosity, Spreadability, and washability, were optimized to ensure stability and efficacy... The findings of this research hold promise for the development of a novel, natural-based therapeutic approach for cataract management, potentially offering improved patient outcomes and quality of life.
Physicochemical Characterisation And Dissolution Properties Of Spironolactone Solid Binary Systems
Authors: Arali Bharati , Devaraj Pruthvi , A Patil Uma , Madhu A
Published: November 2024

Objective: To study the physicochemical characterisation and dissolution properties of Spironolactone complexing it with β-Cyclodextrin and Hydroxypropyl-β-Cyclodextrin in different molar ratios (1:1 M and 1:2 M).
Design Interventions: Spironolactone belonging to BCS class II, exhibits low and variable oral bioavailability due to its poor aqueous solubility. Enhancement in solubility and dissolution rate leads to an increase in its oral bioavailability. Solid binary systems were prepared by Physical mixture, Kneading method, Microwave irradiation and Freeze-drying method. They were evaluated by in vitro dissolution studies and characterised using different analytical techniques. 
Main Outcome Measures: The host guest interactions studied by different techniques confirmed true inclusion of Spironolactone with β-Cyclodextrin and Hydroxypropyl-β-Cyclodextrin at 1:1 M and 1:2 M.
Results: Overall, the rank order of improvement in dissolution properties of Spironolactone with ratios is 1:2 M > 1:1 M, methods Freeze-drying > Microwave irradiation > Kneading method > Physical mixture and complexing agent Hydroxypropyl-β-Cyclodextrin > β-Cyclodextrin.
Conclusion: Among the developed Spironolactone SBSs, the SBS prepared with HP- βCD of 1:2 M ratio by Freeze drying method showed good result in dissolution study which shows the maximum release of drug in the range of 95.6%.
A Review on Impurity Profiling In Pharmaceutical Substances
Authors: Shounak R. Mande  , Shankar S. Yelmame  , Laxmikant B. Borse Laxmikant B. Borse
Published: November 2024

The term "impurity profiling" describes a group of analytical techniques aimed at detecting, identifying, and quantifying residual solvents and organic and inorganic impurities in bulk medications and pharmaceutical formulations. This is the main objective of contemporary drug analysis since it is the most effective method of characterizing the stability and quality of pharmaceutical formulations and bulk drugs. To monitor them, certain analytical methods have to be developed. Even in cases where synthesis, formulation, or production procedures are improved, new purities may emerge from changes made to them. The International Conference on Harmonization (ICH), the US Food and Drug Administration (FDA), and other regulatory organizations are closely monitoring the identification of contaminants in Active Pharmaceutical Ingredients (APIs) and the requirements for their purity. In addition to degraded end products obtained during manufacture, pharmaceutical goods may contain impurities from a range of sources, such as ligands, heavy metals (HMs), catalysts, reagents, and other components like filter aids and similar compounds. The permissible quantities of pollutants found in APIs or formulations are progressively being limited by a number of pharmacopoeias, including the American, British, and Indian pharmacopoeias. Pharmaceutical contaminants are separated and analyzedby employingvarious techniques, that includes infrared spectroscopy, nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry, ultracold extraction column chromatography, and ultraviolet spectrometry. For impurity profiling, this is the hyphenated method that is most frequently employed.
NSAID Carprofen Structure-based Derivatives as potential antibacterial agents
Authors: Nitin Kumar  , Pallavi Manish Lavhale
Published: November 2024

Drug repurposing (DR) is the use of existing drug in new alternative therapeutic role. Antibacterial perspective of non-antibiotic drugs includes NSAIDS are very useful to combat in a variety of infections in clinical practice. Carprofen (2-(6-chloro-9H-carbazol-2-yl)propanoic acid), is a NSAIDS category drug based on potential pharmacophore tricyclic carbazole nucleus, now commonly used in veterinary medicine. This carprofen drug is used in osteoarthritis and postoperative pain in dogs. Around the worldwide, researchers’ significantly revealed drug repurposing role of carprofen structure-based derivatives as antibacterial agents. These carprofen structure-based compounds displayed excellent antibacterial activities against gram positive as well as gram-negative bacterial strains in review literature. Some carprofen derivatives also displayed potential antibiofilm activity. Multi-target direct ligand (MTDLs) strategy also used to design novel carprofen integrated molecules tethered with potential bioactive pharmacophore like coumarin, 1,3,4-oxadiazole, hydrazide etc. also showed significant in vitro antibacterial activities. Articles related to carprofen as antibacterial agents collected on PubMed, Science direct and Google scholar mainly. However, less research works done on this topic. This review highlighted antibacterial potential of new carprofen derivatives based on carbazole structure tested against bacterial strains with their target mechanism based on literature.
AUXÍLIO DO ENFERMEIRO NA HUMANIZAÇÃO NO PARTO NORMAL
Authors: Oliveira e Silva Mayara Bárbara de , Sousa Luiza Araújo Amâncio
Published: November 2024

This study addresses the cruciality of the humanization of normal childbirth, focusing on women and their essential needs during childbirth. By valuing the choices, values, and desires of pregnant women, the aim is to offer comprehensive emotional and physical support, minimizing unnecessary interventions and promoting practices that respect the natural rhythm of labor. The research aims to demonstrate that humanization is not just a theoretical concept but a practical approach essential to ensuring dignity, respect, and individualized care during childbirth, transforming it into a meaningful and healthy experience. With the goal of exploring the benefits of this approach and the role of the nurse in its implementation, the study conducted a narrative literature review. The analysis focused on articles discussing natural and humanized childbirth from the nursing perspective, aiming to characterize the differences between cesarean and normal childbirth, the negative aspects of non-humanized birth experiences, and the importance of nursing in promoting a welcoming and empathetic environment. It is concluded that the humanization of childbirth, both normal and cesarean, is essential to ensuring a safe and respectful experience. The lack of humanization can lead to complications and negative impacts. The nurse plays a central role in implementing these practices, ensuring respect for the woman's autonomy and fostering a welcoming environment for childbirth.
COLETA DE CITOPATOLÓGICO: A importância do conhecimento e da assistência de enfermagem na prevenção do câncer do colo uterino em mulheres com mais 64 anos
Authors: Pereira Candida dos Reis , Bicalho Elizaine Aparecida Guimarães
Published: November 2024

According to the Ministry of Health, it is estimated that in Brazil, cervical cancer is the third most common malignancy, surpassed only by non-melanoma skin cancer and breast cancer. It is the fourth cause of death from cancer in the female population. The aging of the population has accelerated rapidly due to the decrease in fertility and mortality, which generates greater life expectancy, a factor that is accompanied by chronic non-communicable diseases, such as neoplasms. Women over 65 years of age are more resistant to undergoing cytopathological examination, a condition that raises public health concerns due to the complications of uterine cancer for these women, which can even lead to the loss of their lives. The role of nurses in preventing cervical cancer is fundamental, as they play the role of educator and can use innovative methods that arouse women's interest in seeking health services to undergo the examination. The main objective of this research was to find out the contribution of nurses' knowledge in collecting cytopathology in women over 65 years of age. The specific objectives described were: to understand the factors that lead to the occurrence of cervical cancer in women over 65 years of age; identify the role of nurses in welcoming and carrying out preventive examinations in women over 65 years of age; strengthen the importance of diagnosis and promote early diagnosis. The research consisted of a narrative review of the literature about cytopathology collection in women over 65 years of age and the importance of nurses' knowledge and assistance. Searches were carried out on articles published between 2013 and 2023 in articles indexed in the VHL and SCIELO databases that discussed the topic. After the research, it was concluded that nurses have a fundamental role in preventing cervical cancer in women over 65 years of age, both in assisting and welcoming patients in health units, encouraging these women to carry out the test collection cytopathology and to take care of themselves, aiming to prevent cervical cancer.
Guia Tecnológico do Sistema INDL: o passo a passo para a instalação, configuração e manutenção
Authors: Paiva Gustavo Cardoso , Costa Mirele Carolina Souza Ferreira
Published: November 2024

Guia Tecnológico do Sistema INDL : O passo a passo para a instalação, configuração e manutenção
ESBOÇOS DE UMA CORPOREIDADE DECOLONIAL NA DANÇA MODERNA AFRICANA DE GERMAINE ACOGNY
Authors: Éden Peretta  , Thaís Lopes Santos de Azevedo
Published: November 2024

O presente artigo tem como objetivo central percorrer fragmentos da história de vida da dançarina e coreógrafa senegalesa Germaine Acogny, bem como alguns dos princípios de sua dança moderna africana, para problematizar a sua arte colocando-a em diálogo com dimensões do pensamento crítico e decolonial contemporâneo. Neste cruzamento teórico, emergem significativas questões (micro)políticas com as quais torna-se possível delinearmos esboços de uma corporeidade decolonial.
TEATRO E RELIGIÃO
Authors: Jean Carlos Gonçalves  , Cláudio Eduardo Andrade
Published: November 2024

O artigo tem como objetivo compreender o discurso de estudantes evangélicos sobre as práticas teatrais no contexto universitário, especialmente no que se refere à relação entre fé e liberdade artística. A pesquisa foi realizada no âmbito de um curso de graduação na área de Artes Cênicas sediado em uma universidade pública do Brasil. O quadro teórico-metodológico está ancorado na Análise Dialógica do Discurso, que tem nos estudos de Bakhtin e o Círculo sua principal referência. A pesquisa contribui para os campos da educação, da linguagem e das artes, apontando resultados que indicam limites e possibilidades da relação entre teatro e religião, considerando as peculiaridades que constituem a identidade e a alteridade dos sujeitos envolvidos e a defesa de um fazer teatral universitário que consiga preservar, mesmo em meio a processos fundamentalistas e exclusivistas, a autonomia, a laicidade e a democracia.
UM INVENTÁRIO DE ESCRITAS DE SI NA FORMAÇÃO ARTISTA DOCENTE DE DANÇA
Authors: Santos Oneide dos
Published: November 2024

Este ensaio apresenta-se como um inventário de escritas de si entrecruzado com conceitos filosóficos. É parte de uma pesquisa de conclusão de graduação no curso de Dança licenciatura, na Universidade Federal de Santa Maria. A contribuição do ensaio versa sobre reconhecer o inventário, a escrita de si e a dança a partir de diferentes modos, agitando e contrariando as políticas do mover/escrever até então hegemônicas.
A Dialogue of Music between East and West: New Interpretations of 20th-Century Art Songs Based on Ancient Chinese Poems
Authors: Zijing Meng
Published: November 2024

This research aims to combine my two artistic identities as a Chinese zither (古筝) player and as a classical singer. After researching, interpreting and analyzing two art song cycles from the 20th century, 5 Poems of Ancient China and Japan by Charles Griffes and Songs of Autumn (秋之歌) by Zhongrong Luo (罗忠镕), I integrate Chinese traditional music forms, ornamentation and instrumentation into my vocal performance. The methodology includes literature review, expert interview, internet media review, score analysis, language analysis and experimental music practice. The outcomes highlight my approach of incorporating inspiration from zither music and folk singing styles into the art song cycles, while also addressing the ethical considerations encountered throughout the research process.
Analisis Kesalahan Berbahasa pada Teks Eksplanasi Karangan Siswa Kelas VIII MTs Plus Al Bukhori Kabupaten Brebes
Authors: Khalim Khalimatussa'diyah , Indrya Mulyaningsih  , Itaristanti
Published: November 2024

The purpose of this study was to describe language errors at the level of spelling, morphology, and sentences in explanatory texts written by class VIII students of MTs Plus Al Bukhori. This type of research is qualitative with a descriptive design. The data collection method used documentation, data validity used theoretical triangulation, and data analysis used the distribution method. The results showed that in the explanatory text there were 152 spelling errors, 5 morphological levels, and 11 syntactical levels. This research is oriented towards the background of language errors, so that it can be used as a reference material for not making similar mistakes and is able to provide linguistic insight.
Keywords: explanatory text, morphology, spelling, syntax
 
Abstrak
Tujuan penelitian ini adalah untuk mendeskripsikan kesalahan berbahasa pada tataran ejaan, morfologi, dan kalimat dalam teks eksplanasi yang ditulis oleh siswa kelas VIII MTs Plus Al Bukhori. Jenis penelitian ini adalah kualitatif dengan desain deskriptif. Teknik pengumpulan data menggunakan dokumentasi, validitas data menggunakan triangulasi teori, dan analisis data menggunakan metode agih. Hasil penelitian menunjukkan bahwa dalam teks eksplanasi terdapat 152 kesalahan ejaan, 5 tingkat morfologis, dan 11 tingkat sintaksis. Penelitian ini berorientasi pada latar belakang kesalahan berbahasa, sehingga dapat dijadikan bahan rujukan untuk tidak melakukan kesalahan sejenis dan mampu memberikan wawasan linguistik.
Kata kunci: ejaan, morfologi, sintaksis, teks eksplanasi
Perspektif Mata Najwa dalam Episode “Kenapa Kita Butuh Komika”: Kajian Linguistik Kritis
Authors: Zuhriyah Sitiaminataz
Published: November 2024

Youtube content with the title “Why We Need Komika” is Narasi's weekly content containing satirical reflections, criticism and various informative matters. This study aims to look at the perspective of comics in assessing social phenomena, especially on issues of government policy systems with critical linguistic studies. The data source in this study is a video from a YouTube content called Narasi TV owned by Najwa Shihab. The results of the study show that the comic perspective in doing stand-up comedy is the result of reflection as well as satire aimed at elite government officials who often enjoy luxury state facilities but are not swift in dealing with various problems that exist in society. In addition, the results of the study show that comics want to show the condition of Indonesia which is not doing well through images of official imagery from the humor presented by comics.
 
Konten Youtube yang mengangkat judul “Mengapa Kita Butuh Komika” merupakan konten mingguan Narasi yang mengandung refleksi sindiran, kritikan dan berbagai hal yang bersifat informatif. Penelitian ini bertujuan untuk melihat perspektif komika dalam menilai fenomena sosial khususnya pada masalah sistem kebijakan di pemerintahan dengan kajian linguistik kritis. Sumber data dalam penelitian ini adalah video dari konten Youtube bernama Narasi TV milik Najwa Shihab. Hasil penelitian menunjukkan bahwa perspektif komika dalam melakukan stand up komedi merupakan hasil refleksi juga sindiran yang ditujukan kepada pejabat elit pemerintahan yang kerap kali menikmati fasilitas mewah negara namun tidak sigap dalam menangani berbagai masalah yang ada di masyarakat. Selain itu, hasil penelitian menunjukkan bahwa komika ingin memperlihatkan kondisi Indonesia yang sedang tidak baik-baik saja lewat gambaran pencitraan pejabat dari humor yang dibawakan komika.
The Book of Phenomenological Velocity reduced size
Authors: Emmerson Parker
Published: November 2024

This book is dedicated to Yahowah the living one Allaha, who is Yeshua ben Joseph ben David. Thank you for letting me write this book.
Compulsion derived from incentive cocaine-seeking habits is associated with a downregulation of the dopamine transporter in striatal astrocytes
Authors: Fouyssac Maxime , Hynes Tristan , Belin-Rauscent Aude , Joshi Dhaval , Belin David
Published: November 2024

The development of compulsive cue-controlled-incentive-drug-seeking
habits, a hallmark of substance use disorder, is predicated on an
intrastriatal shift in the locus of control over behaviour from a
nucleus accumbens (Nac) core - dorsomedial striatum network to a Nac
core - anterior dorsolateral striatum (aDLS) network. Such shift
parallels striatal adaptations to chronic drug, including cocaine
self-administration, marked by dopamine transporter (DAT) alterations
originating in the ventral striatum that spread eventually to encompass
the aDLS. Having recently shown that heroin self-administration results
in a pan-striatal reduction in astrocytic DAT that precedes the
development of aDLS dopamine-dependent incentive heroin-seeking habits
we tested the hypothesis that similar adaptations occur following
cocaine exposure. We compared DAT protein levels in whole tissue
homogenates and astrocytes cultured from ventral and dorsal striatal
territories of drug naïve male Sprague Dawley rats to those of rats with
a history of cocaine-taking or an aDLS dopamine-dependent incentive
cocaine-seeking habit. Cocaine exposure resulted in a decrease in whole
tissue and astrocytic DAT across all territories of the striatum. We
further demonstrated that compulsive (i.e., punishment-resistant)
incentive cocaine-seeking habits were associated with a reduction in DAT
mRNA levels in the Nac shell, but not the Nac core-aDLS incentive habit
system. Together with the recent evidence of heroin-induced
downregulation of striatal astrocytic DAT, these findings suggest that
alterations in astrocytic DAT may represent a common mechanism
underlying the development of compulsive incentive drug-seeking habits
across drug classes.
Dynamic simulation and life cycle analysis of a 784m2 solar thermal plant with evacuated flat plate collectors coupled to a district heating network
Authors: Duret Alexis , Jobard Xavier , Pauletta Stefano , Lasvaux Sebastien , Frossard Mija , Demonchy Gauthier
Published: November 2024

One of the first solar plants in Switzerland to be integrated to a large
urban district heating network has been monitored since its commissioning
in 2021. Located in Geneva, this 784 m? solar field, equipped with
innovative evacuated flat plate collectors, has confirmed the potential of
vacuum solar collectors for industrial and district heating network
applications. In 2022, the plant achieved a specific annual production of
684 kWh per m?, corresponding to a 45% yearly average efficiency. A dynamic
numerical model, developed under TRNSYS and validated against measurement
data, allowed investigating the impact of several optimization strategies
together with their economic viability. Additionally, a life cycle
assessment and a life cycle cost analysis were conducted, confirming that
incorporating solar heat into district heating network significantly reduces
GHG emissions and non-renewable energy consumption at an energy production
cost which is competitive with that of current district heating networks.
These findings underscore the potential of solar thermal technology in
decarbonating the thermal energy sector, notwithstanding its limited role
in the current energy production arena.
Improving the accuracy of heat pump feasibility assessment
Authors: Kossi Pihla , Rama Miika
Published: November 2024

This research provides techno-economic assessment of three different heat
pump systems within the transition in energy markets. The assessment is
carried out using a generic Microsoft EXCEL tool, which is widely
applicable for cases with different scale, heat sources and output
temperatures. The tool includes profitability and performance calculation
for selected refrigerant conditions and components. The main objective of
the tool is to calculate COP accurately from enthalpies for given demand
and temperatures instead of using Carnot?s efficiency. In the tool, the
price of the electricity is evaluated based on few different scenarios
reflecting the development of electricity prices to comprehensively assess
the long-term profitability of the selected three heat pump systems. The
performance and flexibility of the ground source heat pump in the same
building is evaluated using the tool within three different cases: ground
source heat pump, ground source heat pump and thermal energy storage, and
hybrid operation combining ground source heat pump and district heating. As
a conclusion thermal energy storage along with ground source heat pump
improves the flexibility of the system the most and reduce the dependency
between electricity prices and system profitability. Thermal energy storage
along with heat pump decreased the annual heating cost up to 28% compared to
using solely heat pump.
Mechanical vapor compression and renewable energy source integration into desalination process LIFE-Desirows case example
Authors: Calleja-Cayon Pablo , Molina-Garcia Angel , Vera-Garcia Francisco
Published: November 2024

This paper shows the adequacy of the parameters for correct modelling of a
mechanical vapor compression desalination plant, explores the influences of
parameters considering an energy efficiency vision of the model, indicating
which components affect the most to its final performance and energy
consumption. The present work also offers the preliminary results extracted
from a real experimental facility powered by RES. The case study, in
Cartagena, Spain, as part of the LIFE-Desirows project, aims to address
brine disposal, salt crystallization, nitrate elimination, water resource
recovery, and carbon neutrality. After providing an overview of the current
state of desalination, the focus shifts to brine removal technologies, with
a specific emphasis on mechanical vapor compression. The technical aspects
of coupling such technologies for enhanced energy efficiency in
desalination processes are discussed, along with associated challenges and
limitations, as well as the inputs and outputs considered for the analysis.
The paper reinforces the importance of improving energy efficiency in
thermal desalination processes with its results, fostering a discussion on
potential avenues for further research and development in concentrate
valorization, as well as its positive effects on the environment and
economy.
Numerical study on oxy-biomass co-firing in a cement rotary kiln
Authors: Shu Yixiang , Zhang Hanlin , Zhang Jiaye , Xu Wei , Cheng Yanlong , Zhang Su , Mikulcic Hrvoje , Liao Yuhan , Shi Zhaochen , Guo Yang , Wang Xuebin
Published: November 2024

Cement manufacturing is among the industries with the highest energy
consumption and pollution emissions. Combining oxy-fuel combustion with the
technology of co-firing biomass with coal is a promising way to reduce
pollutant and carbon emissions. Based on a 6000 t per day cement rotary
kiln, the performance of oxy-biomass co-firing technology is investigated by
CFD modeling. Cases under different biomass ratios (0%-30%) and O2
concentrations are simulated. Combustion characteristics including
temperature field, wall heat flux distribution, NOx emissions, etc. are
widely assessed. It is found that biomass co-firing can significantly
reduce ignition delay caused by high CO2 concentration during oxy-fuel
combustion. A flame distribution similar to the conventional air-fired
condition is obtained under conditions of 33% O2 concentration and 10%
biomass co-firing ratio. The wall heat transfer is enhanced in oxy-fuel
cases. With the increase of biomass co-firing ratio, the wall heat flux
tends to be more uniform. Oxy-fuel combustion can effectively reduce NOx
emissions and the fuel-N conversion ratio. Biomass co-firing under oxy-fuel
conditions can reduce the fuel-N conversion ratio from 10.9% to 8%, but it
will lead to a slight increase in NOx emissions from 848 ppm to 899 ppm. It
is necessary to control the co-firing amount of biomass to achieve effective
combustion and pollutant emission control.
Corporate ESG Disclosures and Regulatory Mandates: The Role of Investors’ Perceptions of Greenwashing
Authors: Fanning Kirsten , Hatfield Richard C. , Sealy Chezham L.
Published: November 2024

Given historically lax ESG regulation, management has substantial discretion over whether/how to disclose ESG goals or commitments. As stakeholders question the reliability of corporate ESG disclosures, regulators have proposed and begun to implement ESG reporting mandates. Using an experiment, we examine how investors’ perceptions of greenwashing change when an ESG outcome is disclosed after different types of ESG goals were issued in both voluntary and mandatory regulatory reporting regimes. Although challenging quantitative ESG goals are encouraged to incent more ESG activity, we first document that investors’ perceptions of greenwashing increase when a company misses a quantitative goal, but they decrease when a company beats a quantitative goal or issues a qualitative goal, even when corporate ESG outcomes are identical in all cases. Mandates further exacerbate changes in investors’ greenwashing perceptions by magnifying the positive and negative effects of quantitative ESG goals, which in turn, drives changes in investment willingness.

Data Availability: Data are available from the authors upon request.
Association of Insulin Resistance With Radiographic Lung Abnormalities and Incident Lung Disease: The Framingham Offspring Study
Authors: Raju Sarath , Sierra Paula , Tejwani Vickram , Staggers Kristen A. , McCormack Meredith , Villareal Dennis T. , Rosas Ivan O. , Hanania Nicola A. , Wu Tianshi David
Published: November 2024

OBJECTIVE

Insulin resistance (IR) may be a risk factor for lung disease, but objective evidence is limited. We sought to define the relationship of longitudinal IR with radiographic imaging outcomes and examiner-identified incident lung disease in the Framingham Offspring Study.

RESEARCH DESIGN AND METHODS

Participants without baseline lung disease underwent repeated measurements of fasting insulin and glucose levels over an average period of 13.6 years, from which time-weighted average HOMA-IR was calculated. Each participant then underwent a cardiac gated whole-lung computed tomography scan, which was analyzed for the presence of emphysema, interstitial lung abnormalities (ILAs), and quantitative airway features. Incident lung disease was determined by a study examiner. The relationship of HOMA-IR to these outcomes was estimated in models adjusted for demographics, BMI, and lifetime smoking.

RESULTS

A total of 875 participants with longitudinal IR data and outcomes were identified. Their mean age was 51.5 years, and BMI was 26.7 kg/m2. HOMA-IR was temporally unstable, with a within-person SD approximately two-thirds of the between-person SD. In adjusted models, a 1 SD increase in log(HOMA-IR) z score was associated with higher odds of qualitative emphysema (odds ratio [OR] 1.33; 95% CI 1.04–1.70), ILAs (OR 1.35; 95% CI 1.05–1.74), and modest increases in airway wall thickness and wall area percentage. These radiographic findings were corroborated by a positive association of HOMA-IR with incident lung disease.

CONCLUSIONS

IR is associated with radiographic lung abnormalities and incident lung disease. Deeper phenotyping is necessary to define mechanisms of IR-associated lung injury.
Tracking insulin- and glucagon-expressing cells in vitro and in vivo using a double reporter human embryonic stem cell lineUntitled Item
Authors: Mar Samantha , Filatov Ekaterina , Sasaki Shugo , Mojibian Majid , Zhang Dahai , Yang Angela , Nian Cuilan , C. Lynn Francis
Published: November 2024

Human embryonic stem cell (hESC)-derived pancreatic alpha and beta cells can be used to develop cell replacement therapies to treat diabetes. However, recent published differentiation protocols yield varying amounts of alpha and beta cells amidst heterogeneous cell populations. To visualize and isolate hESC-derived alpha and beta cells, we generated a GLUCAGON-2A-mScarlet and INSULIN-2A-EGFP dual fluorescent reporter (INSEGFPGCGmScarlet) hESC line using CRISPR/Cas9. We established robust expression of EGFP and mScarlet fluorescent proteins in insulin- and glucagon-expressing cells respectively without compromising the differentiation or function of these cells. We also showed the insulin- and glucagon-expressing bihormonal population at the maturing endocrine cell stage (Stage 6) of our pancreatic islet differentiation lose insulin expression over time, while maintaining an alpha-like expression profile, suggesting these bihormonal cells are cell autonomously fated to become alpha-like cells. We also demonstrated this cell line can be used to monitor hESC-derived insulin- and glucagon-expressing cells, and hESC-derived islet morphology in vivo by transplanting them into the anterior chamber of the eye in mice. Together, the INSEGFPGCGmScarlet hESC line provides an efficient strategy for tracking populations of hESC-derived beta- and alpha-like cells.
The peer review process: Growing problem in recruiting qualified reviewers
Authors: Holmstrup Palle
Published: November 2024

N/A
Efficacy of Entomopathogenic Nematode, Steinernema abbasi PN-1 against Helicoverpa armigera Hubner
Authors: Vireesha P. , Pandey R. , Shashikala M. , Mehra N. , Kumar S.
Published: November 2024

The experiment was conducted during May 2022 at College of Agriculture, G. B. Pant University of Agriculture & Technology, U. S. Nagar, Pantnagar, Uttarakhand, India. The Steinernema abbasi PN-1 is a local isolate of entomopathogenic nematode isolated from the soil collected from Uttarakhand, India. Under the present study, virulenceof Steinernema abbasi PN-1 against different stages of Helicoverpa armigera Hubner were tested. Virulence studies of S. abbasi PN-1 against H. armigera proved that all larval stages and pupae of H. armigera were found susceptible to the IJs of S. abbasi PN-1. There was a positive correlation between insect mortality and the nematode concentration. The S. abbasi PN-1 caused 100% larval mortality at 48–60 h of post treatment in all tested doses in laboratory. Among the larval instars, 4th instar larvae of H. armigera were more susceptible with a median lethal concentration (LC50) value of 24.37 IJs larva-1 and the median lethal time (LT50) values of 25.63 hours. The 2nd instar larvae was least susceptible with an LC50 value of 78.96 IJs larva-1 and LT50 values of 41.33 hours. The pupal stage was less susceptible than the larval stage with the LC50 value of 98.3 IJs larva-1. Our results showed that S. abbasi PN-1 can be used as efficient biological control agents against H. armigera with further field studies.
Conhecimento de residentes da atenção primária à saúde sobre as políticas públicas brasileiras relacionadas à amamentação
Authors: Feitosa Antonio Lucas Ferreira , Depolli Gabriel Trevizani , Tavares Josivânia Santos , Silva Maria Gabriella Pacheco da
Published: November 2024

Introdução: O envolvimento dos residentes da atenção primária à saúde na promoção, apoio e proteção da amamentação depende diretamente de seu conhecimento e entendimento das políticas públicas relacionadas a essa questão. Objetivo: Analisar o nível de conhecimento dos residentes da atenção primária à saúde sobre as políticas públicas brasileiras relacionadas à amamentação. Métodos: Estudo transversal. Participaram residentes ativos em programas Multiprofissional e Médica da Atenção Primária à Saúde de diversas instituições e localidades, com inclusão daqueles que ofereciam assistência direta a mães lactantes e seus bebês. Os dados foram coletados online por um questionário estruturado. Resultados: Participaram 129 residentes, com faixa etária entre 22 e 29 anos (75,2%), predominantemente mulheres (85,3%) e predominância da Enfermagem (n= 30;23,3%), Medicina (n=26;20,2%), Odontologia (n=16;12,4%), Nutrição (n=12;9,3%) e Fisioterapia (n=10;7,8%). Apenas 15,5% realizaram curso de amamentação, e 94,6% estava ciente da exclusividade até seis meses. 34,9% afirmaram ter conhecimento sobre a existência da Norma Brasileira de Comercialização de Alimentos para Lactentes e Crianças de Primeira Infância, 38,8% (n=50) conheciam a Estratégia Amamenta e Alimenta Brasil, e apenas 36,4% (n=47) conheciam a estratégia de apoio à mulher trabalhadora que amamenta. Conclusão: Residentes apresentaram baixo conhecimento sobre as políticas públicas de amamentação, destacando lacunas na identificação dos principais objetivos e estratégias das políticas, evidenciando lacunas educacionais que variam conforme a formação profissional.
Vocabulário expressivo em crianças nascidas a termo e pequenas para a idade gestacional
Authors: Rios Noemi Vieira de Freitas , Fernandes Luciene da Cruz , Andrade Caio Leônidas Oliviera de , Ferreira Emily de Jesus , Santiago Ana Cecília , Alves Crésio de Aragão Dantas
Published: November 2024

Introdução: O peso ao nascer e a idade gestacional influenciam a qualidade de vida das crianças e devem ser levados em consideração na avaliação de aspectos do desenvolvimento. Objetivo: verificar o desempenho em avaliação do vocabulário expressivo de crianças nascidas a termo e pequenas para a idade gestacional e compará-lo com crianças nascidas a termo e com peso adequado para a idade gestacional. Método: estudo transversal, do tipo analítico, com amostras por conveniência, não-pareada, aninhada a uma coorte. Avaliaram-se 36 crianças, entre quatro e sete anos, sendo 24 (66,7%) classificadas como pequenas para a idade gestacional e 12 (33%) adequadas para a idade gestacional. O vocabulário expressivo foi avaliado pelo teste de linguagem infantil ABFW. Os resultados foram avaliados por análise descritiva e analítica, utilizando o teste t não pareado, o teste qui-quadrado de Pearson e o teste exato de Fisher, com nível de significância p<0,05. Resultados: a média de designação do vocábulo usual foi inferior em todos os campos semânticos, exceto no campo conceitual vestuário. Identificaram-se, ainda, diferenças para meio de transporte (p=0,002) e formas/cores (p=0,011). A média de não designação foi acima ou igual em todos os campos conceituais, observando-se diferença significativa para alimentos (p= 0,019), móveis/ utensílios (p=0,020) e locais (p= 0,049). As médias do processo de substituição foram mais elevadas, na maioria dos campos semânticos, com diferença apenas para meio de transporte (p= 0,002).Conclusão: crianças pequenas para a idade gestacional nascidas a termo apresentaram desempenho abaixo do esperado nas provas de vocabulário expressivo quando comparadas com as crianças adequadas para a idade gestacional a termo.
Ekstrakurikuler Karawitan: Media Pembelajaran dan Pelestarian Budaya di SMA 1 Padang Panjang
Authors:   Program Studi Seni Karawitan, Institut Seni Indonesia Padangpanjang, Firdaus Firdaus , Firman Afif Rahman ,   Program Studi Seni Karawitan, Institut Seni Indonesia Padangpanjang, Admiral Admiral ,   Program Studi Seni Karawitan, Institut Seni Indonesia Padangpanjang, Arnailis Arnailis ,   Program Studi Seni Karawitan, Institut Seni Indonesia Padangpanjang, Elizar Elizar ,   Program Studi Seni Karawitan, Institut Seni Indonesia Padangpanjang
Published: November 2024

The aim of this study is to explore efforts to preserve the art of karawitan through extracurricular programs at SMA 1 Padang Panjang, with a specific focus on the use of the traditional musical instrument Pupuik Batang Padi. Karawitan, which includes traditional music and other traditional instruments, holds significant philosophical, aesthetic, and spiritual values within Indonesian culture. However, the influence of globalization and popular culture poses a threat to the existence of this art form among younger generations. This research adopts a descriptive qualitative approach, utilizing techniques such as observation, in-depth interviews, and documentation of extracurricular activities. The results indicate that teaching karawitan through the making and playing of Pupuik Batang Padi not only enhances students' technical skills but also fosters a sense of pride and responsibility towards their cultural heritage. The program has proven effective in strengthening students' cultural identity, instilling values of mutual cooperation, discipline, and respect for nature. Moreover, the program contributes to the preservation of Minangkabau traditional arts, with students actively bringing their skills into the public sphere by participating in local cultural events. These findings underscore the importance of integrating traditional arts into education as a medium for cultural preservation and character development in the face of globalization challenges.

Keywords: Extracurricular, Karawitan, Cultural Preservation, Pupuik Batang Padi