bluuebunny/crossref_metadata_2025 huggingface dataset:
Análise crítica de três guias oficiais de validação de métodos analíticos em vigor no Brasil
Authors: Helena Vieira Debora , Cal Moreira Wildeberg , Ribeiro Seródio Lilia , França Presgrave Octávio Augusto , Dallagiovanna Bruno , Corrêa de Moura Wlamir
Published: January 2025

Introdução: a partir do século XX, com o surgimento das indústrias farmacêuticas após a descoberta da penicilina, acidentes envolvendo fármacos impulsionaram os avanços que culminaram na criação e adoção das boas práticas de fabricação nesta área e, paralelamente, dos princípios e uso mandatório das validações dos processos produtivos e métodos analíticos. Em geral, o guia de validação do ICH é o mais utilizado nesta área. No entanto, têm sido relatadas divergências nas definições dos parâmetros de validação contidos neste guia e em outros. No Brasil existem três guias oficiais em vigor (ANVISA, INMETRO e MAPA). Objetivo: analisar criticamente as definições das características de validação contidas nas normas brasileiras oficiais de validação e sua concordância com as definições padrão. Métodos: selecionar na literatura específica as definições das características de validação mais coerentes cientificamente e utilizá-las como definições padrão na avaliação das normas oficiais brasileiras. Resultados: verificou-se que a concordância das três normas oficiais brasileiras com as definições padrão foi de 37,5%, ANVISA; 50%, INMETRO e 62,5%, MAPA. Conclusões: é fundamental ter definições claras e cientificamente relevantes para as diferentes características de validação e utilizar métodos estatísticos adequados para a sua avaliação. Uma harmonização entre as diferentes normas oficias seria de grande importância para evitar discrepâncias entre os setores regulados pelos diferentes orgãos no país.
Bone therapy through drug delivery of chelated [bisphosphonate-metal ions] adsorbed on the surface of carbon nanotubes
Authors: Mollaamin Fatemeh , Monajjemi Majid
Published: January 2025

Aim: To investigate asingle-walled carbon nanotube (SWCNT) joint to bisphosphonate agents of 5AEL, 5AFX, 4QPF, 3DYG, 2F92, 2I19 chelated to metal cations of Mg2+, Ca2+, Sr2+ due to the direct electron transfer principle which has been studied by density functional theory methods. Method: It has been accomplished the B3LYP/6-311+G(d,p)/LANL2DZ to estimate the susceptibility of SWCNT for adsorbing 5AEL, 5AFX, 4QPF, 3DYG, 2F92, 2I19 chelated to metal cations of Mg2+, Ca2+, Sr2+ through nuclear magnetic resonance and thermodynamic parameters. Results: The data explained that the feasibility of using SWCNT and bisphosphonate agents becomes the norm in metal chelating of delivery system, which has been selected through several bisphosphonate agents of 5AEL, 5AFX, 4QPF, 3DYG, 2F92, and 2I19 using DFT method due to physico-chemical properties of NMR and IR methodologies.
TRAIL receptors as prognostic markers and survival predictors in ovarian cancer: A systematic review of clinical studies and meta-analysis
Authors: Silva Luciana Maria , De Sousa Gomes Kamila , Calaça Paula , Moreira Brito Julio Cesar
Published: January 2025

Introduction: TRAIL cytokine (TNF-Related Apoptosis-Inducing Ligand) interacts with five receptors, four of which are expressed at the plasma membrane (DR4, DR5, DcR1, DcR2), and the fifth is a soluble osteoprotegerin receptor (OPG). Only the death receptors DR4 and DR5 contain the cytoplasmic death domain (DD), which is involved in triggering the apoptotic cascade. These receptors are found in tumor cells of various types, including ovarian cancer cells. Purpose: The aim of this article is to describe in a systematic review the presence of death receptors in cancer cells of patients and to discuss the clinical implications of this approach on various signs and clinical mechanisms of cancer. Method: The systematic review was performed on June 1, 2022, using PubMed Central - PMC, SCOPUS (Elsevier), Web of Science, Cochrane Library, and Biblioteca Virtual em Saúde - BVS (BIREME). The data were summarized in tables and critically analyzed. After the database search, five relevant studies were identified for review. Results: Analysis of these studies revealed evidence of increased survival in patients with ovarian cancer who detected these receptors in cancer tissue. In addition, we seek to understand the biological mechanisms involved in the resistance of cancer cells to TRAIL-induced apoptosis.
Joint Occurrences of Competing Risks and Multivariate Longitudinal Data: A Prediction Investigation for the HIV. long Data
Authors: Kazempoor Jaber , Habibirad Arezou , Sinha Sanjoy
Published: January 2025

In this article, some prediction strategies are introduced for event times, where multivariate data with competing or semi-competing risks are simultaneously collected. Without loss of generality, the proposed methods can be used to analyze multivariate longitudinal data with competing or semi competing risks, often encountered in social sciences and sports activities. Regarding the situations mentioned earlier, we can provide the prediction values of: I. Time of occurrences of any cause for specific individuals II. Time of subsequent events for some cause in other individuals III. The covariate values on predicted time of I and II. Accordingly, doctor assistants or nurses can schedule good visiting times based on I and II. Item III can provide the missing values of all covariates that are utilized for better modeling.  The corresponding statistical background is extensively discussed. Finally, an actual data set has been analyzed, the prediction values are provided, and their performances are assessed.
Unit Regression Models to Explain Vote Proportions in the Brazilian Presidential Elections in 2018
Authors: Rojas Guerra Renata , Peña-Ramírez Fernando A. , Fontana Ribeiro Tatiane , Moutinho Cordeiro Gauss , Peixoto Mafalda Charles
Published: January 2025

In this paper, we aim to identify the covariates associated with the proportion of votes of candidates elected in Brazilian municipalities with a population of more than 300,000 inhabitants. We analyzed the vote proportions from the 2018 presidential runoff election using distributions within the Generalized Additive Models for Location, Scale, and Shape (GAMLSS) class. Unit distributions are quite useful for modeling vote proportions due to their flexibility to accommodate asymmetry and heavy tails. Furthermore, they provide adequate representations of the physiological properties and the empirical distribution of the data. We _t the beta, simplex, unit gamma, and unit Lindley regression models, considering random and fixed effects components to verify spatial correlation among the municipalities. The beta regression with fixed components regarding Brazilian regions is superior. The covariates with significant effects are the proportion of evangelicals, monthly household income per capita, the political spectrum of the governors' party elected in 2014 and 2018, and if the municipality is the capital of the state. We note that some Brazilian regions impact the vote proportions' mean and dispersion.
Data-Driven Modeling of Impact of Differential Efficacy of COVID-19 Vaccines in Two Socio-Economically Contrasting Cities: New York, USA and Bogotá, Colombia
Authors: Martinez-Salinas Erika Johanna , Arunachalam Viswanathan , Seibel Caitlin , Huang Yutian , Reisman Jackson , Kgosimore Moatlhodi , Mubayi Anuj , Seshaiyer Padmanabhan
Published: January 2025

In an effort to curb the spread of COVID-19, various types of vaccines, including mRNA, viral vectors, and traditional ones, were globally approved and implemented. However, the distribution of vaccines in each country became a critical and determining factor in the disease's evolution. The present study aims to understand the differential impact of the different available vaccine types on disease burden. A proposed mathematical model considers multiple vaccines in a community to analyze the dynamics of COVID-19 transmission in two socioeconomically diverse regions. Secondary incidence data for the cities of Bogotá, Colombia, and New York, USA, from March 2020 to December 2021 were used to estimate vaccine-related parameters and actual transmission rates. The results suggest that although New York has more effective vaccines, higher vaccination rates, and lower poverty rates compared to Bogotá, its disease burden was significantly higher due to higher population density and, consequently, a greater number of contacts. This indicates that while more effective vaccines are crucial to flattening the curve, social distancing measures are equally important for quickly controlling the disease if the vaccination rate is not sufficiently high. Additionally, the model successfully captures the epidemiological behaviour of transmission through the use of vaccines, calculating the basic reproductive number in different scenarios and estimating the parameters of the proposed model.
Small Samples, New Viruses, Inputs for Decision-Making and Methodology: Bootstrap and Smote
Authors: Rodríguez Gómez Wilson Fernando , Misas-Arango Martha , Pereira-Villa Catherine , Gomez-Gonzalez José E.
Published: January 2025

This study presents a comprehensive methodology that combines resampling and oversampling techniques to address the challenges of limited and balanced data, specifically in the context of viral emergencies such as the COVID-19 pandemic. Utilizing advanced statistical techniques like Bootstrap and SMOTE, the study conducts a retrospective analysis of COVID-19 patients, identifying those at higher risk of mortality. The proposed methodology not only enhances the accuracy of predictions in scenarios with limited data but also facilitates better decision-making in clinical triage systems. By applying these methods, the study achieves early and accurate identification of high-risk individuals, optimizing resource allocation and timely medical interventions. The results demonstrate that this combination of statistical techniques effectively improves health systems and responses to new viral threats, providing a robust foundation for informed decision-making in medical emergencies.
“Ver a cidade”: o Porto artístico de Mário Cláudio*
Authors: Caser da Costa Mariana
Published: January 2025

em Meu Porto (2001), o escritor português Mário Cláudio apresenta sua cidade natal não apenas sob os vieses turístico e literário, que, inevitavelmente, a leitura traz à tona, mas opta por inscrever o Porto em uma profícua recolha afetiva. Assim, ruas, construções, monumentos, pinturas, narrativas, receitas culinárias e filmes, além de efabulações, anedotas e memórias, tripeiras e pessoais, constituem o Porto artístico de Mário Cláudio. Para “ver a cidade” sob o óculo marioclaudiano, a presente leitura baseia-se nas ideias teórico-críticas de, entre outros, Georges Didi-Huberman, Maria Theresa Abelha Alves e Dalva Calvão, além de na produção do próprio escritor, bem como na de outros artistas portuenses, como Helder Pacheco e Manoel de Oliveira – respectivamente, cronista e realizador, que contribuem, na obra, com a elaboração dessa espécie de mapa afetivo-estético da cidade Invicta. Com este texto, pretende-se demonstrar que Mário Cláudio, escritor da contemporaneidade, cria visualidades complementares ao texto literário, que dialoga intensamente com outras formas de expressão artística, quer pelo destaque dado ao caráter autorreflexivo de sua literatura, quer pelos recortes artísticos da cidade e sobre ela, que a referida obra dá a ler/ver.
El claustro de San Agustín de Tunja (Colombia): un museo de sitio
Authors: Martínez-Martín Abel , Otálora-Cascante Andrés , Burgos-Bernal Alejandro
Published: January 2025

este artículo reúne una investigación histórica y una reflexión museológica sobre el claustro de San Agustín de Tunja (Colombia), en proceso de restauración. A partir de fuentes primarias y secundarias se reconstruyeron los usos y funciones que tuvo este espacio, construido en el siglo XVII sobre el cercado del zaque muisca, por la orden agustina, cuyos integrantes decoraron el interior del conjunto con pintura mural sobre San Agustín y dotaron la iglesia con altares y retablos relacionados con la orden. Con la Independencia y la instauración de la república en el siglo XIX, el claustro fue convertido en convento-hospital de la orden hospitalaria de San Juan de Dios, quienes incorporaron sus bienes muebles. Posteriormente, el claustro fue usado como cuartel y penitenciaría, siguiendo el modelo panóptico, uso que mantuvo hasta el siglo XX, cuando fue abandonado y se convirtió en ruinas. Tras una primera restauración, funcionó como centro cultural del Banco de la República en la ciudad. En el marco de la actual restauración, estos elementos sirvieron para reflexionar sobre la importancia del lugar y realizar una propuesta para la creación de un museo de sitio, que integre los múltiples encierros del que ha sido testigo este espacio.
The Principal Symbol Map for Lagrangian Distributions with Complex Phase
Authors: Mattar Marriaga Gisel
Published: January 2025

The present paper focus on Lagrangian distributions with complex phase. We provide an alternative construction of their principal symbol map, which allows us to compute the principal symbol after clean composition of Fourier integral operators with complex phase.
Normality of k-Matching Polytopes of Bipartite Graphs
Authors: Torres Juan Camilo
Published: January 2025

The k-matching polytope of a graph is the convex hull of all its matchings of a given size k when they are considered as indicator vectors. In this paper, we prove that the k-matching polytope of a bipartite graph is normal, that is, every integer point in its t-dilate is the sum of t integers points of the original polytope. This generalizes the known fact that Birkhoff polytopes are normal. As a preliminary result, we prove that for bipartite graphs the k-matching polytope is equal to the fractional k-matching polytope, having thus the H-representation of the polytope. This generalizes the Birkhoff-Von Neumann Theorem which establish that every doubly stochastic matrix can be written as a convex combination of permutation matrices.
Eventos adversos de vacunas contra la COVID-19 en un servicio médico universitario de Bogotá, Colombia
Authors: Vaca-González Claudia , Vahos Juanita , Páez Sergio , Páez Mariana , López José Julián
Published: January 2025

Introducción. Los ensayos clínicos no proporcionaron evidencia suficiente sobre el efecto a largo plazo, ni sobre los posibles eventos adversos de las vacunas contra la COVID-19, en especial en los países del sur global. La farmacovigilancia activa permite realizar una adecuada evaluación de la relación riesgo-beneficio de estas vacunas en contextos no controlados.
Objetivos. Determinar la frecuencia de eventos supuestamente atribuibles a la vacunación o inmunización (ESAVI) de las vacunas contra la COVID-19 en personas afiliadas a una unidad de servicios de salud universitaria de Bogotá, Colombia, y evaluar los factores de riesgo asociados a una mayor probabilidad de presentar ESAVI.
Materiales y métodos. Estudio transversal analítico realizado en 4 078 personas afiliadas a la Unidad de Servicios de Salud de la Universidad Nacional de Colombia (UNISALUD), sede Bogotá, que habían recibido al menos una dosis de vacunas contra la COVID-19 entre marzo de 2021 y abril de 2022. Los datos fueron recolectados a través de una encuesta telefónica e información clínica provista por UNISALUD. Se desarrolló un modelo de regresión logística para evaluar la asociación entre presentar ESAVI y sexo, edad, vacuna recibida, presencia o antecedente de alergias, uso de medicamentos concomitantes, existencia de comorbilidades y consumo de medicamentos y sustancias para prevenir la COVID-19.
Resultados. La edad promedio de los participantes fue 69.3 años, 57.14% (n=2 330) eran mujeres y 36.6% (n=1 495) indicaron haber presentado al menos un ESAVI (2 477 ESAVI en total), principalmente dolor en el lugar de la inyección (n=754), dolor no especificado (n=321), cefalea (n=301) y fatiga (n=272); además, Moderna fue la vacuna con la mayor proporción de participantes que sufrió ESAVI (77.42%; 24/31), seguida de Janssen (59.60%; 59/99) y Pfizer (49.43%; 783/1 584). Los factores de riesgo para presentar ESAVI fueron: sexo (femenino), edad (<65 años), presencia o antecedente de alergias, uso de terapia hormonal, uso de azitromicina, padecimiento de enfermedad cardiovascular y la vacuna recibida (Moderna o Pfizer comparadas con AstraZeneca).
Conclusiones. Un poco más de un tercio de los participantes reportaron al menos un ESAVI luego de la administración de las vacunas contra la COVID-19, siendo Moderna la vacuna con la que hubo una mayor proporción de pacientes que presentaron ESAVI. La edad, el género, el uso de terapia hormonal, el uso de azitromicina, las comorbilidades cardiovasculares y la vacuna recibida se asociaron como factores de riesgo para la aparición de ESAVI.
Diseño y validación del material educativo incluido en una estrategia de educación en salud dirigida a personas con enfermedades cardiovasculares e impartida vía WhatsApp
Authors: Jácome-Hortúa Adriana Marcela , Pinto-Prada Adriana , Quintero-Tibaduiza Natalia , Luna Paula Alejandra , Olaya-Grass Tania Lucia , Daza-Acosta Liz Patricia , Anaya-Ocampo Katherine , Rincón-Rueda Zully Rocío
Published: January 2025

Introducción. Las enfermedades cardiovasculares (ECV) son la principal causa de muerte en el mundo. Se ha comprobado que la rehabilitación cardiaca ofrece beneficios a los pacientes con ECV; sin embargo, pocos perduran en el tiempo debido a la pobre adherencia, lo cual podría estar influenciado por la falta de programas de educación estructurados.
Objetivos. Diseñar y validar el material educativo incluido en una estrategia de educación en salud impartida vía WhatsApp dirigida a personas con ECV usuarios de un programa de rehabilitación cardiaca (PRC).
Materiales y métodos. Estudio de métodos mixtos basado en el proceso de investigación-creación y desarrollado en dos etapas: etapa de diseño y elaboración de la estrategia educativa y etapa de validación del material educativo, la cual incluyó una validación técnica (participación de 8 profesionales de la salud) y una validación por público objetivo (participación de 6 pacientes con ECV usuarios de un PCR-fase 2). Se siguieron los lineamientos de la Organización Panamericana de la Salud para la elaboración y validación de material educativo en salud.
Resultados. La versión 1 de la estrategia tenía 26 piezas educativas (17 imágenes, 5 audios y 4 videos), de las cuales 96.3% se calificaron en “dejar como está”. Teniendo en cuenta las sugerencias en contenido y forma hechas por los expertos, en la versión 2 se incluyeron 31 piezas educativas (22 imágenes, 5 audios y 4 videos). Posterior a la validación de público objetivo, la versión final del material consistió de 30 ítems (21 imágenes, 4 audios y 5 videos).
Conclusión. En el presente estudio fue posible diseñar y validar material educativo dirigido a usuarios de un PRC que, al estar centrado en el paciente y ser de fácil difusión vía una red social ampliamente utilizada, se convierte en una herramienta que puede ayudar a mejorar la adherencia a estos programas.
Este ensayo clínico fue registrado en el Australian New Zealand Clinical Trials Registry bajo el código ACTRN12622001446752.
Resultados funcionales y cosméticos en pacientes peruanos con luxación acromioclavicular: comparación entre tres técnicas quirúrgicas
Authors: Vargas-Morales Renán Estuardo , Puga-Alvarez Karla Sophía
Published: January 2025

Introducción. La luxación acromioclavicular (LA) es una lesión frecuente e incapacitante. Dependiendo de su tipo según la clasificación de Rockwood, el tratamiento puede ser conservador (I-II) o quirúrgico (III-VI); sin embargo, aún no hay un estándar de oro en términos de la técnica quirúrgica.
Objetivos. Comparar los resultados funcionales y el nivel de satisfacción de los pacientes con los resultados cosméticos de tres técnicas quirúrgicas para el tratamiento de la LA.
Materiales y métodos. Estudio observacional comparativo retrospectivo realizado en 90 pacientes adultos con LA (tipo III y V) en los que se realizó manejo quirúrgico entre enero de 2013 y agosto de 2023 en cuatro hospitales de Trujillo (Perú) con una de las siguientes técnicas: dos suturas con incisión en correa de sujetador (DS; n=30), placa en gancho (PG; n=30) y Phemister modificada (PM; n=30). Los cuestionarios usados para obtener información sobre los resultados funcionales y el nivel de satisfacción con los resultados cosméticos se administraron a partir del tercer mes posoperatorio. Se realizaron análisis bivariados para realizar comparaciones entre grupos (pruebas de KrusKall-Wallis y Chi Cuadrado), con un nivel de significancia de p<0.05.
Resultados. La edad promedio de los pacientes fue 42.41 años y 74.44% (n=67) eran hombres. El puntaje en el cuestionario Quick DASH fue más bajo en el grupo DS (15.23±8.5) que en las otras 2 técnicas (PG=17.64±10.4 y PM=25.96±6.7) (p=0.0002). Asimismo, el tiempo de discapacidad (meses) fue más corto en el grupo DS (2.1±0.23) que en los otros dos grupos (PG=4.66±1.22 y PM=2.93±1.18) (p=0.019). Finalmente, 61.11% de los pacientes refirieron estar satisfechos y totalmente satisfechos con los resultados cosméticos, siendo esta proporción más alta en la técnica DS (76.67%), seguida de PM (60.00%) y PG (46.67%) (p<0.005).
Conclusión. De las tres técnicas evaluadas, la técnica DS mostró mejores resultados funcionales. Además, la proporción más alta de pacientes satisfechos con los resultados cosméticos se observó en el grupo DS.
Colgajos perforantes de las arterias geniculares lateral y medial superior como alternativas para la reconstrucción de defectos alrededor de la rodilla: reporte de tres casos
Authors: Torres-Fuentes Carlos Eduardo , Barrera-Pinzón Lorena , Ruiz-Abuanza Daniel Andrés , Padilla-Rojas Julián Esteban
Published: January 2025

Introducción. Los colgajos perforantes de la arteria genicular lateral superior (AGLS) y la arteria genicular medial superior (AGMS) se han propuesto como alternativa para la reconstrucción de defectos alrededor de la rodilla en lugar del uso de colgajos musculares, los cuales tienen varias desventajas como alteración de la funcionalidad de la extremidad, mayor morbilidad del sitio donante y pobres resultados cosméticos.
Presentación de casos. Se presentan tres casos clínicos de pacientes con defectos de tejidos blandos alrededor de la rodilla (los primeros dos en el aspecto lateral y el tercero en la porción medial) en los que se usaron colgajos perforantes de las arterias geniculares para la reconstrucción de los defectos (AGLS en los casos 1 y 2, y AGMS en el caso 3). En los tres casos se obtuvieron resultados funcionales y cosméticos satisfactorios al mes de seguimiento; además, solo un paciente presentó una complicación (hematoma posoperatorio en el sitio del colgajo), la cual fue resuelta sin problemas. Los tres pacientes eran hombres de 57, 41 y 18 años admitidos a una institución de salud de cuarto nivel de atención de Bogotá (Colombia). La causa del defecto fue un accidente de tránsito en los tres casos.
Conclusión. Los colgajos perforantes de la AGMS y de la AGLS demostraron ser una opción segura y efectiva para cubrir defectos de tejidos blandos alrededor de la rodilla, lográndose resultados funcionales y estéticos satisfactorios en los tres casos reportados.
Effects of self-management interventions in adults with acute coronary syndrome: A systematic review and meta-analysis of randomized controlled trials
Authors: De las Salas Roxana , Velasco Banquet Lorena Isabel , Villarreal Cantillo Elizabeth , Palmet Jimenez Marta
Published: January 2025

Objective The aim of this study is to determine the effects of self-management interventions in adults with Acute Coronary Syndrome.
Methods Systematic review and meta-analysis. The Prisma checklist was used. Embase via Ovid, Lilacs, Medline via PubMed and Central were searched for randomized controlled trials. The Cochrane collaboration guidelines were followed and reported using the Preferred Reporting Items for Systematic Reviews and MetaAnalyses (Prisma) statement. The Revman program was used to consolidate the data. A sensiti- vity analysis was carried out.
Results A total of 17 randomized controlled trials met eligibility criteria. The results showed that self-management interventions did not significantly enhance patients’ com- pliance with medication OR=1.32 (95% CI 0.66-2.64), lifestyle changes OR=1.08 (95% CI 0.55-2.15) and modification of clinical variables MD=-1.77 (95% CI -2.96 6.50).
Conclusion This review suggests that there are no statistically significant differences between self-management interventions and the usual care given to patients with Acute Coronary Syndrome Compliance with Pharmacological Treatment, lifestyle changes and Changes in Clinical Variables.
Espaço público digital e ativismo dos coletivos
Authors: Lima Neto Fernando
Published: January 2025

Este artigo analisa a relação dialógica entre os constrangimentos estruturais referentes ao uso crescente de ferramentas digitais de comunicação e as ações de ativistas de coletivos que recorrem a essas ferramentas para imputar novos sentidos sobre participação e política. O recurso a ferramentas digitais de comunicação, a ênfase na biografia pessoal como motivação para o engajamento político, o adensamento das relações de amizade na luta política e o discurso da horizontalidade são algumas dimensões do novo ativismo político dos coletivos que indicam a redefinição de padrões estruturantes da cultura política no Brasil, como a própria separação entre público e privado. Em linhas gerais, o artigo se debruça sobre pesquisa empírica para argumentar que o ativismo dos coletivos e o debate teórico sobre espaço público no século 21 constituem um jogo de espelhos, a transformação de um está refletida no outro.
LA MUERTE DIGNA EN EL ESTADO DE DERECHO COSTARRICENSE
Authors: Sánchez Astúa Karine
Published: January 2025

El presente artículo de investigación aborda el concepto de muerte digna en el derecho costarricense, por medio de votos jurisprudenciales que han establecido la muerte digna como corolario de la dignidad humana, abriendo paso a una breve discusión por medio del derecho comparado de sí nuestra interpretación actual se encuentra acorde con el principio de dignidad. Lo anterior partiendo de la premisa de que en un Estado Social de Derecho el acceso a la salud debe prestarse respetando la autodeterminación de sus administrados y la vida de manera integral, pudiendo con esto decidir cada persona no sólo sobre su proyecto de vida, sino también, sobre cómo llevar su muerte, sin que se dé un rebasamiento de la voluntad de un paciente terminal.
Māori data sovereignty and privacy
Authors: Kukutai Tahu , Cassim Shemana , Clark Vanessa , Jones Nicholas , Mika Jason , Morar Rhianna , Muru-Lanning Marama , Pouwhare Robert , Teague Vanessa , Tuffery Huria Lynell , Watts David , Sterling Rogena
Published: January 2025

Privacy is a fundamental human right. One of its most important aspects is information privacy –
providing individuals with control over the way in which their personal data is collected, used,
disclosed and otherwise handled. Existing information privacy regulation neither recognises nor
protects the collective privacy rights of Indigenous peoples. This paper explores Indigenous data
privacy, and the challenges and opportunities, in the context of Aotearoa. It has two aims: to identify
gaps in existing data privacy approaches with regards to Indigenous data, and to provide a foundation
for progressing alternative privacy paradigms. We argue that while personal data protection is
necessary, it is insufficient to meet the needs of Māori and Aotearoa more broadly. In so doing, we
draw on three areas of research: Indigenous and Māori data sovereignty; data and information privacy,
including collective privacy; and Māori and Indigenous privacy perspectives. We examine key
features of the Aotearoa privacy context – including the Privacy Act 2020 (NZ) – and consider the
implications of te Tiriti o Waitangi and tikanga Māori for alternative privacy approaches. Future
options, including legal and extra-legal measures, are proposed.
What is a State of the Art (SotA) review?
Authors: Rodionova Yu. V. , Kim O. T.
Published: January 2025

State of the Art (SotA) literature reviews are chronological overviews of the current status of knowledge about a phenomenon and suggest directions for future research. The publication discusses the methodological principles of writing this type of review.
Long-term knowledge retention in medical genetic disciplines: relationship with teaching format and learning styles
Authors: Rozenfeld S. V. , Vatskel E. A. , Vanchakova N. P. , Korzhenevskaya M. A.
Published: January 2025

Aim. To study the long-term knowledge retention in medical genetic disciplines and its reference to teaching format and learning styles.

Material and methods. Knowledge retention was assessed in General Medicine students (n=63; men, 16%; women, 84%). The data was obtained in the 4th year full-time students and 1st year mixed (in-person and distance) students (retrospectively). Knowledge retention was assessed by analyzing academic performance tests. Learning styles were studied using the Learning Styles Questionnaire (LSQ).

Results. When comparing the knowledge retention in medical and biological disciplines studied in person (Genetics in year 1) and online (Parasitology in year 1), no significant difference was found. At the same time, after updating the genetics knowledge obtained in year 1 in the 4th year, students showed better results in the Medical and Biological Consulting course than in "factual" reproduction of knowledge. Reflective and theoretician learning styles dominated in 4th year students.

Conclusion. It is necessary to develop professional thinking associated with the logic of professional activity and allowing one to quickly update what has been studied and supply the deficient knowledge. The assumption about the favorable influence of the theoretician and reflective learning styles needs verification in further studies.
Simulation training technology as a new paradigm of modern medical education
Authors: Orlov Yu. V. , Mutigullina A. A.
Published: January 2025

The article discusses the use of simulation training technologies within professional medical education of residents and practitioners, including in the field of Obstetrics and Gynecology. The authors describe the advantages of simulation training technologies and basic principles of educational process. The article provides examples of the most successful forms of classes using simulators of varying levels of realism. Solutions of main organizational and methodological problems of using simulation training technologies and the prospects for the development of presented methods are determined.
Social demographic patterns and participation in the Gariep Dam fishery, South Africa, during the Covid-19 pandemic
Authors: PJ Swanepoel  , LM Barkhuizen  , BR Ellender  , LL van As  , OLF Weyl
Published: January 2025

The global Covid-19 pandemic resulted in an economic downturn that influenced behavioural and participation patterns of fishing sectors around the world. Monitoring changes in fisheries is essential for understanding their human dimension and informing decision-making for development, conservation and management of fish resources. This study documented and described fishery patterns and participation during the Covid-19 pandemic through roving creel surveys. In addition, due to historic surveys of the recreational and subsistence fishery, it was possible to compare the current patterns to previous results and to show the potential Covid-19 related impacts. Subsistence fishing dominated the fishery, with 94% of 431 regular fishers utilising the resources for home consumption or sale. Compared to historic surveys, a marked decline in estimated recreational fishing was observed, but no significant change was identified in participation patterns of subsistence fishers. This downturn in recreational fishing affected the socio-demographic characteristics of the fishery, where changes in ethnic participation were noted; there was also an increase in the number of unemployed fishers during the pandemic. Utilisation of the fish resources was dominated by subsistence users and 97% of fish caught was for self-consumption or sale. This underlines the importance of fish for subsistence users, who rely on the resource for food or income and could not avoid fishing during the pandemic, as they had no alternative. This study highlights the importance of socio-demographic and participation data on fisheries, to provide scientific advice to policymakers on ideal responses to events such as a pandemic. This evidence of temporal changes in hook-and-line fisheries provides inland fishery authorities the opportunity to develop mitigation measures with greater resilience to cope with future global crises. Lastly, the study emphasises the importance of access to fisheries, especially during times of high regional economic and societal stress.
Dependence of long-term annual rainfall trends in South Africa on analysis period: 1921–2022
Authors: Andries C Kruger
Published: January 2025

The focus of the paper is to address the temporal discrepancies in long-term rainfall trend results in South Africa, by evaluating a systematic range of observation periods over the century-long analysis period of 1921–2022. Available long-term climate projections show that significant parts of South Africa are expected to experience progressively drier conditions, mainly in the west. To assess long-term rainfall trends over the country, historical trends should be determined – the results of published studies for which are not consistent. Arguably the most significant reason for these inconsistencies is the length of analysis period. This study investigates this effect on the magnitude and statistical significance of historical annual rainfall trends over hydrological years, with the data of 94 homogeneous rainfall districts. Trends of annual rainfall were determined for all periods up to 2022, from the 1921–2022 period up to the last 30 years, i.e. 1993–2022. The annual rainfall trends over the longest analysis period show significantly positive trends over most of the central and western parts and significant drying over extensive parts of mainly the far north-east. However, the most recent period (1993–2022) shows significantly drying trends over extensive parts of the west, south and east. Among the main findings is that the change in trends shows a consistent spatial pattern of significant negative change over most of the south-western half, and mostly significantly positive trends over the north-eastern sector. These results are in large agreement with future rainfall projections, particularly for the western half. Ultimately, the study emphasizes the wide range of long-term trends in South Africa, both spatially and temporally, and the importance of considering a range of historical analysis periods in the detection of long-term rainfall changes. In effect, the eventual results provide increased confidence to predicted future rainfall scenarios.
Occurrence of volatile organic contaminants in tap water due to the use of plastic plumbing pipes
Authors: Awadh O AlSuhaimi  , Ahad A Fantoukh  , Eman A AlHarbi  , Mohammed M Shaikh  , Mohammed M Shaikh  , Imran Ali
Published: January 2025

In the present era, polymeric pipes have emerged as the replacement for metallic alternatives in constructing water distribution networks within cities or homes, due to their notable flexibility and durability. Nevertheless, there have been increased concerns over the safety of consuming water that has come into contact with polymeric materials. This issue arises from the possible leaching of organic contaminants, either due to plastic deterioration or from biofilms that typically develop within polymeric pipes. These biofilms may act as a source of disinfection byproducts during water and/or system disinfection. The objective of the study was to investigate the presence of volatile organic compounds (VOCs) that could migrate from plastic plumbing pipes into tap water. For this purpose, 50 tap water samples from different houses within the Al-Madinah Al-Munawwarah residential area (Saudi Arabia) were collected and analysed for the occurrence of VOCs; trichloromethane (1,1,1-TCA), dichloropropane (1,2-DCP), 1,2,3-trichloropropane (1,2,3-TCP) benzyl chloride (BC) 2-nitropropane (2-NP) 2,4-dichlorophenol (2,4-DCP), 4-ethylphenol (4-EP), benzene and 2-butanone using CG-MS. The most prevalent compounds were benzene, 2-butanone, 1,1,1-TCA, 1,2-DCP, BC, and 1,2,3-TCP. These were identified in 78%, 76%, 68%, 58%, 50%, and 42% of the samples assessed, respectively. The levels of 1,2,3-TCP, benzene, 2,4-DCP and BC exceeded the allowable limit in 43%, 10%, 8% and 6% of the samples, respectively. The remaining VOCs were within the WHO standards. The analysis of water source samples revealed the presence of BC, 1,2-DCP, and 4-EP in 40%, 40%, and 30% of samples, respectively, with no other VOCs detected. This suggests that these contaminants primarily originate from polymeric pipes used in household plumbing systems.
RELATÓRIOS DE SUSTENTABILIDADE EM CONSTRUTORAS NO ESTADO DE MATO GROSSO: UM OLHAR PARA A MATERIALIDADE
Authors: Ferreira Luciana Maria de Almeida Silva , Durante Luciane Cleonice , Carvalho Ana Vitória Silva de , Callejas Ivan Julio Apolonio , Silva Benedito Albuquerque da , Souza Paulo Augusto Ramalho de , Alcântara Liliane Cristine Schlemer , Silva Joaquim Manoel da , Blumenschein Raquel Naves , Bacarji Alencar Garcia
Published: January 2025

A construção civil é considerada uma atividade poluidora e de elevado impacto ambiental negativo, apesar de gerar muitos empregos e movimentar grande monta de investimentos e recursos. Por isso, apresenta elevado potencial de se posicionar de forma alinhada aos pilares Environmental, Social and Governance – ESG. O objetivo deste artigo é analisar como as empresas construtoras do estado de Mato Grosso-Brasil operam a agenda ESG em sua estratégia de negócio, identificando os indicadores mais recorrentes nos Relatórios de Sustentabilidade. A metodologia baseou-se nos aportes metodológicos da pesquisa qualitativa, aplicada e exploratória, com amostragem em conglomerado de duas etapas para selecionar os Relatórios de Sustentabilidade analisados. Os resultados evidenciaram a existência de cinco empresas atuantes no Estado e que reportam seus resultados à luz da metodologia Global Reporting Initiative (GRI). Essas empresas relatam de forma comum 11 indicadores, enquanto 24 não são abordados por nenhuma delas e quatro não se aplicam ao setor. Conclui-se que, embora haja uma movimentação em prol das práticas ESG, muitos dos indicadores relatados se limitam ao cumprimento de demandas normativas, sem efetivos avanços para as premissas ESG.
SISTEMAS ADAPTATIVOS COMPLEXOS E DESINFORMAÇÃO: AS DINÂMICAS DA DESINFORMAÇÃO SOBRE AS UNIVERSIDADES NA PERSPECTIVA DA COMPLEXIDADE
Authors: Santos Carlos Maycon Almeida , Araújo Júnior João da Silva , Santos Lívia Karoline Pinheiro Mendonça dos , Barbosa Gustavo Nascimento , Alencar Waldérick de Oliveira Mendes , Aragão Ana Sara Sousa , Menezes Vera Lúcia Moraes Araujo , Soares Geovanna Ghabrielly Humphreys , Pereira Kathianne Maria de Macêdo Silva , Pereira Talliandra Aparecida Fonseca
Published: January 2025

Este artigo tem como objetivo analisar as dinâmicas da desinformação que circula nas redes sociais sobre as universidades a fim de identificar os métodos utilizados (Melquiades da Silva; Valadares Cendón, 2022). Para tal, partimos da seguinte questão: quais métodos são empregados nas dinâmicas da desinformação relacionadas às universidades? Nesse sentido, delimitamos nosso corpus para as desinformações checadas por duas agências de fact-checking – Lupa e Boatos.org – no período de janeiro de 2018 a novembro de 2023. Assim, para este estudo, selecionou-se 4 notícias falsas para análise. A pesquisa fundamenta-se nas discussões de Santaella (2019, 2023) e Magaly Prado (2022), que definem a desinformação como a disseminação intencional de informações falsas com o objetivo de enganar. Também nos apoiamos nas contribuições de Larsen-Freeman e Cameron (2008) sobre sistemas adaptativos complexos, compreendidos como sistemas compostos por diferentes tipos de agentes e elementos que interagem de diversas formas. Além disso, utilizamos o trabalho de Melquiades da Silva e Valadares Cendón (2022), que discutem os métodos empregados nas dinâmicas de desinformação, definidos como meios estruturados para atingir o público-alvo. A análise dos dados revelou que as dinâmicas da desinformação direcionadas às universidades exploram pautas morais e recorrem a apelos emocionais, assim, recorrem a diversos métodos, como o uso do hoaxes.
Evaluation the Effects of Different Silica Coating Methods and Silane Types on the Bond Strength Between Polyamide and Polymethylmethacrylate
Authors: İşisağ Özer , Evcin Atilla
Published: January 2025

Objectives: The aim of this study is to evaluate the effect of different silica coating methods and silane applications on the bond strength between polyamide and polymethylmethacrylate (PMMA).
Methods: Forty-five polyamide specimens were divided into two main groups based on the coating method applied: sol-gel silica coating (S) and tribochemical silica coating (T). Each main group was further divided into two subgroups based on the type of silane used: Bisco Porcelain Primer (BPP) and Clearfil Primer Plus (CPP) (n=9). The control group (C) received no silica coating or silane application. PMMA was then bonded to all specimens, and shear bond strength was evaluated.
Results: The highest shear bond strength was observed in group T with BPP application, while the lowest value was recorded in group C. Statistically significant differences were found between S-T and T-C groups (P<.05). Although BPP application in group T resulted in higher bond strength than CPP, the opposite trend was observed in group S.
Conclusion: The shear bond strength between polyamide and PMMA can be enhanced by applying silane after silica coating using either the tribochemical or sol-gel method.
Keywords: Polyamide, Polymethylmethacrylate, Silica
Influence of Preheating Procedure and Polymerization Modes on Degree of Conversion of Contemporary Resin Composites
Authors: Yenidünya Özge Gizem , Erdem Ahmet , Akgül Nilgün , Yazkan Başak , Özcan Mutlu
Published: January 2025

Objective: To evaluate the effects of preheating procedure and polymerization modes on degree of conversion (DC) of resin composites.
Methods: Three different types of composites - a conventional (GrandioSO - [GSO]), a bulkfill (GrandioSO x-tra - [GSX]), and a thermoviscous bulkfill (VisCalor bulk - [VCB]) - were investigated. Three specimens were prepared for each combination of the variables (composite type*preheating procedure*polymerization mode). Photo-polymerization was performed using an LED operated in standard (SM), high power plus (HM), and x-tra power (XM) modes. DC was measured with Fourier Transform Infrared Spectroscopy after 5 min and 24 h post-irradiation. Furthermore, three-way analysis of variance followed by a Tukey test at a significance level of P <.05 were performed to compare the DC values.
Results: Considering the DC values at two post-irradiation time, preheated VCB group polymerized with HM gave the highest DC value, while GSX cured with XM, regardless of the preheating exhibited the lowest one. Preheating application caused a statistically significant increase in the DC values of the VCB*SM, VCB*HM, and GSO*HM groups at both evaluation periods, and the GSX*SM group at 24h post-irradiation. Regarding the polymerization mode, the ranking depending on the significant differences among all preheated composites tested at both time intervals was HM > SM > XM.
Conclusion: Preheating generally exhibited favorable effects on the DC of all tested composites, with the most significant impact observed in VCB. Additionally, polymerization with x-tra power mode is not recommended to achieve a sufficient DC required for clinically acceptable restorations.
Keywords: bulk fill composite; degree of conversion; FTIR; polymerization mode; preheating; thermoviscousity
Control Techniques for MPPT of Grid Connected Photovoltaic Systems
Authors: Ahmad Khan Shamim
Published: January 2025

A grid-connected PV system is analyzed in this paper using MPPT techniques. A major goal of research has been finding methods that extract solar energy more efficiently, which has attracted numerous researchers towards photovoltaics (PVs). The nonlinear behavior of the device determines its output based on a variety of factors, including solar temperature and ambient irradiance. Using MPPT techniques, PV cells can achieve their maximum output. P&O and incremental conductance are two MPPT techniques that are most commonly used in this paper. As well as PWM techniques, three grid-connected inverters operating at 240 kV are compared. Solar energy systems must use Maximum Power Point Tracking (MPPT) to maximize power output under variable irradiation and climate conditions. This research deals with two MPPT algorithms for PV arrays connected to the grid: Perturb and Observe (P&O), and Fuzzy Logic Control (FLC). Analyzing and comparing the results of both algorithms is performed using MATLAB/Simulink.
Features of the clinical course of endometriosis in papillomavirus infection
Authors: Khanova Aigul M. , Khachaturian Armine R. , Khusnutdinova Tatiana A. , Savicheva Alevtina M. , Yarmolinskaya Maria I.
Published: January 2025

Background: To date, the etiology and pathogenesis of endometriosis are still unclear and are determined by a number of factors (genetic, immunological and endocrine), including microbiological ones.
Aim: The aim of this study was to characterize the clinical course of endometriosis in papillomavirus infection.
Materials and methods: This retrospective analysis included 185 outpatient records of patients with genital endometriosis and comprised complaints, anamnesis data, objective examination, cytological and molecular biological examination results. All patients were divided into two study groups. Group 1 (main) consisted of patients with endometriosis and human papillomavirus (n = 56), and group 2 (comparison) included patients with endometriosis and no human papillomavirus (n = 129).
Results: The frequency of human papillomavirus detection among patients with endometriosis was 30.3 (95% confidence interval 24–38)%. The most frequent types detected were 31 (20%), 16 (18%), 18 (18%), 56 (16%), and 53 (13%). The conclusion of cervical cytological examination: in group 1 was the following 54/56 patients had negative for intraepithelial lesion or malignancy (NILM) and 2/56 patients had low grade squamous intraepithelial lesion (LSIL), all patients in group 2 had NILM. The average duration of endometriosis was 8.2 ± 5.0 years for patients in group 1 and 9.4 ± 5.9 years for patients in group 2 (p = 0.15). We found differences between the study groups with respect to the following parameters: the average age of sexual debut was 17.82 ± 1.47 years and 18.53 ± 1.43 years for groups 1 and 2, respectively. Dyspareunia occurred in 77 (95% confidence interval 63–87)% of women in Groups 1 and in 42 (95% confidence interval 33–51)% in groups 2 (p 0.001). The average pain severity score according to the visual analogue scale was 6.7 ± 2.4 and 5.9 ± 2.8 points, respectively (p = 0.039). In group 1, impaired vaginal microbiocenosis was more common.
Conclusions: Human papillomavirus was detected in every third woman with endometriosis, most often in genotypes of high carcinogenic risk. Among the features of the clinical course of endometriosis in the presence of human papillomavirus, more pronounced pain syndrome and symptoms of dyspareunia were noted. In the group of women with human papillomavirus, impaired vaginal microbiocenosis was more often observed.
Pliegos de cordel y relaciones de sucesos. La ingente aportación de María Cruz García de Enterría al estudio de la literatura popular áurea
Authors: Pena Sueiro Nieves
Published: January 2025

Remembranza de la aportación de la profesora María Cruz García de Enterría (1934-2021) al estudio de la Literatura popular española de los siglos XVI y XVII, especialmente la que se imprimía en pliegos sueltos poéticos.