bluuebunny/crossref_metadata_2025 huggingface dataset:
The Xenogeneic Silencer Histone-Like Nucleoid-Structuring Protein Mediates the Temperature and Salinity-Dependent Regulation of the Type III Secretion System 2 in Vibrio parahaemolyticus
Authors: Pratama Andre , Ishii Eiji , Kodama Toshio , Iida Tetsuya , Matsuda Shigeaki
Published: December 2022

In the major seafood-borne pathogen
Vibrio parahaemolyticus
, the type III secretion system 2 (T3SS2) is a major virulence factor that is responsible for the enterotoxicity of this bacterium. The expression of T3SS2 varies according to changes in temperature and salinity, but the mechanism via which T3SS2 expression is regulated in response to such physical cues remains unknown.
Anogenital condylomata acuminata in young children: not always result of sexual transmission
Authors: Dias Joana Valente , Gomes Sónia , Afonso Helga , Teles Rita
Published: December 2022

Condylomata acuminata lesions, commonly known as anogenital warts, are caused by human papillomavirus and manifest as flesh-coloured or hyperpigmented papules or plaques in the anogenital region. We report the case of a previously healthy young child that presented with anal condyloma lesions without other accompanying symptoms. His mother had similar lesions in the genital area. After careful investigation, no evidence of sexual abuse was found. Gradual clinical improvement was observed without treatment. This case highlights a disease that, when diagnosed in children, should alert the physician to the possibility of sexual abuse. However, other transmission routes, such as vertical transmission or autoinoculation and heteroinoculation during non-sexual contact, should also be considered.
Patient outcomes in public sector hepatitis C treatment programmes: a retrospective cohort analysis across five low- and middle-income countries
Authors: Boeke Caroline E , Adesigbin Clement , Adisa Olayinka , Agwuocha Chukwuemeka , Akanmu Muhammad-Mujtaba , Anartati Atiek , Aung Khin Sanda , Azania Amy , Bello Nabe Ruth , Budiman Arief , Chan Yuhui , Chawla Umesh , Fatchanuraliyah  , Fernandes Oriel , Grover Gagandeep Singh , Naing Thandar Su , Ngo Dang , Ramers Christian B , Regan Sean , Sindhwani Siddharth , Tandy Gertrudis , Tint Khin , Nguyen Kinh Van , Witschi Magdalena , McClure Craig
Published: December 2022

Objectives

Given limited data on factors associated with hepatitis C virus (HCV) treatment discontinuation and failure in low- and middle-income countries, we aimed to describe patient populations treated for HCV in five countries and identify patient groups that may need additional support.

Design

Retrospective cohort analysis using routinely collected data.

Setting

Public sector HCV treatment programmes in India (Punjab), Indonesia, Myanmar, Nigeria (Nasarawa) and Vietnam.

Participants

104 957 patients who initiated treatment in 2016–2022 (89% from Punjab).

Primary outcomes

Treatment completion and cure.

Results

Patient characteristics and factors associated with outcomes varied across countries and facilities. Across all patients, median age was 40 years (IQR: 29–52), 30.6% were female, 7.0% reported a history of injecting drugs, 18.2% were cirrhotic and 4.9% were coinfected with HIV. 79.8% were prescribed sofosbuvir+daclastasvir. Of patients with adequate follow-up, 90.6% (89,551) completed treatment. 77.5% (69,426) of those who completed treatment also completed sustained virological testing at 12 weeks (SVR12), and of those, 92.6% (64 305) were cured. In multivariable-adjusted models, in most countries, significantly lower treatment completion was observed among patients on 24-week regimens (vs 12-week regimens) and those initiated in later years of the programme. In several countries, males, younger patients <20 years and certain groups of cirrhotic patients were less likely to complete treatment or be cured. In Punjab, treatment completion was also lower in those with a family history of HCV and people who inject drugs (PWID); in other countries, outcomes were comparable for PWID.

Conclusion

High proportions of patients completed treatment and were cured across patient groups and countries. SVR12 follow-up could be strengthened. Males, younger people and those with decompensated cirrhosis on longer regimens may require additional support to complete treatment and achieve cure. Adequate programme financing, minimal user fees and implementation of evidence-based policies will be critical to close gaps.
Protocol for an observational cohort study investigating biomarkers predicting seizure recurrence following a first unprovoked seizure in adults
Authors: Adan Guleed H , de Bézenac Christophe , Bonnett Laura , Pridgeon Michael , Biswas Shubhabrata , Das Kumar , Richardson Mark P , Laiou Petroula , Keller Simon S , Marson Tony
Published: December 2022

Introduction

A first unprovoked seizure is a common presentation, reliably identifying those that will have recurrent seizures is a challenge. This study will be the first to explore the combined utility of serum biomarkers, quantitative electroencephalogram (EEG) and quantitative MRI to predict seizure recurrence. This will inform patient stratification for counselling and the inclusion of high-risk patients in clinical trials of disease-modifying agents in early epilepsy.

Methods and analysis

100 patients with first unprovoked seizure will be recruited from a tertiary neuroscience centre and baseline assessments will include structural MRI, EEG and a blood sample. As part of a nested pilot study, a subset of 40 patients will have advanced MRI sequences performed that are usually reserved for patients with refractory chronic epilepsy. The remaining 60 patients will have standard clinical MRI sequences. Patients will be followed up every 6 months for a 24-month period to assess seizure recurrence. Connectivity and network-based analyses of EEG and MRI data will be carried out and examined in relation to seizure recurrence. Patient outcomes will also be investigated with respect to analysis of high-mobility group box-1 from blood serum samples.

Ethics and dissemination

This study was approved by North East—Tyne & Wear South Research Ethics Committee (20/NE/0078) and funded by an Association of British Neurologists and Guarantors of Brain clinical research training fellowship. Findings will be presented at national and international meetings published in peer-reviewed journals.

Trial registration number

NIHR Clinical Research Network's (CRN) Central Portfolio Management System (CPMS)—44976.
Developing and testing unconditional cash transfer strategies among young adults with first-episode psychosis in South Africa: a study protocol for a pilot randomised control trial (PRS-FEP trial)
Authors: Mlay Joyce Protas , Jamieson Lise , Ntlantsana Vuyokazi , Naidu Thirusha , Bhengu Busisiwe Siphumelele , Paruk Saeeda , Burns Jonathan K , Chiliza Bonginkosi , Lessells Richard , Tomita Andrew
Published: December 2022

Introduction

Access to mental health services is a challenge, especially for young people who are over-represented in the unemployment and poverty index in South Africa. Therefore, continuing care is a problem after hospital discharge for young people with first-episode psychosis (FEP) due to a lack of clinical engagement and follow-up, for which they need support, including financial, to improve their outcomes. This pilot randomised control trial (RCT) aims to assess the feasibility and acceptability of financial support, in the form of an unconditional cash transfer (UCT), among young patients with FEP to prevent relapse.

Methods and analysis

This study will use a 1:1 ratio two-arm open-label pilot RCT of 60 young participants (18–29 years) with FEP in remission, who will be recruited from specialised psychiatric facilities in KwaZulu-Natal Province, South Africa. This study will implement an UCT and assess its feasibility, acceptability and preliminary clinical outcomes (ie, medication adherence, relapse, quality of life, personal and social function). The follow-up time will be 3 months, the outcomes being measured at baseline, months 1 and 3. Descriptive and conventional content analysis will be done for quantitative and qualitative data, respectively.

Ethics and dissemination

The study obtained provisional approval from the Biomedical Research Ethics Committee at the University of KwaZulu-Natal(#BREC/00004117/2022). Also is registered on the South African National clinical trial registry (#DOH-27-092022-5894) and approved by the KwaZulu-Natal department of health (#NHRD Ref: KZ_2002209_033). The results from this investigation will be actively disseminated through peer-reviewed journal publications, conference presentations and stakeholder engagement.

Trial registration number

DOH-27-092022-5894.
Evaluating a novel, integrative dashboard for health professionals’ performance in managing deteriorating patients:a quality improvement project
Authors: Alhmoud Baneen , Melley Daniel , Khan Nadeem , Bonicci Timothy , Patel Riyaz , Banerjee Amitava
Published: December 2022

Background

The quality of recording and documentation of deteriorating patient management by health professionals has been challenged during the COVID-19 pandemic. Non-adherence to escalation and documentation guidelines increases risk of serious adverse events. Electronic health record (EHR)-integrated dashboards are auditing tools of patients’ status and clinicians’ performance, but neither the views nor the performance of health professionals have been assessed, relating to management of deteriorating patients.

Objective

To develop and evaluate a real-time dashboard of deteriorating patients’ assessment, referral and therapy.

Settings

Five academic hospitals in the largest National Health Service (NHS) trust in the UK (Barts Health NHS Trust).

Intervention

The dashboard was developed from EHR data to investigate patients with National Early Warning Score (NEWS2)>5, assessment, and escalation of deteriorating patients. We adopted the Plan, Do, Study, Act model and Standards for Quality Improvement Reporting Excellence framework to evaluate the dashboard.

Design

Mixed methods: (1) virtual, face-to-face, interviews and (2) retrospective descriptive EHR data analysis.

Results

We interviewed three nurses (two quality and safety and one informatics specialists). Participants perceived the dashboard as a facilitator for auditing NEWS2 recording and escalation of care to improve practice; (2) there is a need for guiding clinicians and adjusting data sources and metrics to enhance the functionality and usability. Data analysis (2019–2022) showed: (1) NEWS2 recording has gradually improved (May 2021–April 2022) from 64% to 83%;(2) referral and assessment completion increased (n: 170–6800 and 23–540, respectively).

Conclusion

The dashboard is an effective real-time data-driven method for improving the quality of managing deteriorating patients. Integrating health systems, a wider analysis NEWS2 and escalation of care metrics, and clinicians’ learning digital solutions will enhance functionality and experience to boost its value. There is a need to examine the generalisability of the dashboard through further validation and quality improvement studies.
Prognostic value and tumour microenvironment characteristics of the Glasgow Microenvironment Score in primary triple-negative breast cancer
Authors: Lu Xunxi , Wang Yue , He Mengting , Gou Zongchao
Published: December 2022

Aims

The Glasgow Microenvironment Score (GMS) reflects the tumour microenvironment (TME) status by combining inflammatory cell infiltration and the tumour-stroma percentage. This study aimed to investigate the prognostic value and TME characteristics of the GMS for patients with triple-negative breast cancer (TNBC).

Methods

A total of 123 patients with stage I-III TNBC were enrolled in this study. The association between GMS and clinicopathological characteristics was examined using the Pearson’s χ2test or Fisher’s exact test. Kaplan-Meier plots were used to compare survival among the three GMS groups. Cox regression analyses were conducted to test the HR. Microenvironment Cell Populations-counter algorithm was used to estimate the TME components of each case.

Results

We found that higher GMS score tended to exhibit the lower nuclear grade (p=0.016), more positive lymph nodes (p=0.014) and later tumour, node, metastases stage (p=0.012). GMS was an independent prognostic factor for disease-free survival in TNBC, and GMS 2 showed the worst prognosis (HR=6.42, p=0.028). GMS 0 was more infiltrated with cytotoxic lymphocytes, including CD8+ T cells (p=0.037) and natural killer cells (p=0.005), while GMS 2 was enriched in more endothelial cells (p=0.014) and fibroblasts (p=0.008).

Conclusion

Our study suggested that the GMS is a prognostic indicator for patients with TNBC. As an accessible and effective index, the GMS may be a promising tool to help clinicians assess prognostic risk and TME for patients with TNBC.
GTF2Imutation in micronodular thymoma with lymphoid stroma
Authors: Bille Andrea , Fryer Katherine , Wallace Andrew , Nonaka Daisuke
Published: December 2022

Aims

Micronodular thymoma with lymphoid stroma is a rare subtype of thymoma with characteristic clinical and pathological features. Some of the features, such as indolent nature, principally spindle morphology and no significant association to myasthenia gravis, are shared with type A and AB thymoma, which is closely linked toGTF2Imutation. However, not much is known regarding the molecular genetics of this thymoma subtype. In this study, theGTF2Imutation status was investigated in 16 cases of micronodular thymoma.

Methods

16 micronodular thymomas were retrieved and the GTF2I mutation was tested by Sanger sequencing. The clinicopathological findings were documented.

Results

GTF2I c.1271T>A p.(Leu424His) mutation within exon 15 was detected in 14 out of 16 tumours (87.5%). Two patients died of other causes while all others remained alive with no evidence of recurrence during the follow-up period ranging from 19 to 188 months (median: 100 months).

Conclusions

GTF2I mutation status and presence of spindle cell morphology may indicate that type A and AB thymoma, and micronodular thymoma represent a group biologically distinct from type B thymomas, which generally lack this mutation.
Vagus nerve stimulation paired with rehabilitation for motor function, mental health and activities of daily living after stroke: a systematic review and meta-analysis
Authors: Gao Yong , Zhu Yi , Lu Xiao , Wang Nannan , Zhu Shizhe , Gong Jianqiu , Wang Tong , Tang Shao-Wen
Published: December 2022

Objective

Vagus nerve stimulation (VNS) plus rehabilitation (Rehab) has shown a potential effect on recovery with a stroke. We systematically synthesised studies examining VNS+Rehab for improving motor function, mental health and activities of daily living (ADL) postintervention and at the end of follow-up in patients with a stroke.

Methods

The search was performed in electronic databases EMBASE, Medline, EBSCO, Cochrane Library, PubMed, PsycINFO, CINAHL, CNKI, and WANFANG and three clinical trial registries from inception to February 2022. Randomised controlled trials (RCTs) applied VNS+Rehab in stroke were included.

Results

Seven RCTs involving 263 (analysed) participants was included. The effect size of VNS+Rehab over Rehab for motor function was medium postintervention (g=0.432; 95% CI 0.186 to 0.678) and large at the end of follow-up (g=0.840; 95% CI 0.288 to 1.392). No difference was found in the effect of VNS+Rehab over traditional rehabilitation for ADL, mental health or safety outcomes. Subgroup analyses revealed larger effects for patients received taVNS (transcutaneous auricular VNS) devices (at acute/subacute phase of stroke, with lower VNS stimulation frequency or pluses per session, greater VNS on-off time or sessions, higher VNS intervention weekly frequency).

Conclusion

The results suggest VNS+Rehab showed better motor function outcomes in patients after stroke, while no better than Rehab on mental health or ADL. Combinations of phase of stroke, specific parameters of VNS and VNS intervention frequency are key modulators of VNS effects.

Trial registration number

CRD42022310194
Evaluating the impact of cannabinoids on sleep health and pain in patients with chronic neuropathic pain: a systematic review and meta-analysis of randomized controlled trials
Authors: McParland Aidan Leonard , Bhatia Anuj , Matelski John , Tian Chenchen , Diep Calvin , Clarke Hance , Kapustin Daniel , Triveda Aditya , Brull Richard , Singh Mandeep
Published: December 2022

Background

Chronic neuropathic pain is often debilitating and can have a significant impact on sleep health and quality of life. There is limited information on the impact of cannabinoids on sleep health when treating neuropathic pain.

Objective

The objectives of this systematic review and meta-analysis were to determine the effect of cannabinoids on sleep quality, pain intensity, and patient impression of treatment efficacy in patients with neuropathic pain.

Evidence review

Nine available medical literature databases were searched for randomized controlled trials comparing synthetic and natural cannabinoids to placebo in patients with neuropathic pain syndromes. Data on validated tools for sleep quality, pain intensity, patients’ global impression of change (PGIC), and incidence of adverse effects of cannabinoids were extracted and synthesized.

Findings

Of the 3491 studies screened, eight randomized controlled trials satisfied the inclusion criteria for this review. Analyses were performed using R -4.1.2. using themetaforpackage and are interpreted using alpha=0.05 as the threshold for statistical significance. Validated measures for sleep health were not used in most studies. Meta-analysis of data from six studies showed that cannabinoids were associated with a significant improvement in sleep quality (standardized mean difference (SMD): 0.40; 95% CI: 0.19 to −0.61, 95% prediction interval (PI): −0.12 to 0.88, p-value=0.002, I2=55.26, τ2=0.05, Q-statistic=16.72, GRADE: moderate certainty). Meta-analysis of data from eight studies showed a significant reduction in daily pain scores in the cannabinoid (CB) group (SMD: −0.55, 95% CI:−0.69 to −0.19, 95% PI: −1.51 to 0.39, p=0.003, I2=82.49, τ2=0.20, Q-statistic=47.69, GRADE: moderate certainty). However, sleep health and analgesic benefits were associated with a higher likelihood of experiencing daytime somnolence, nausea, and dizziness.

Conclusions

Cannabinoids have a role in treating chronic neuropathic pain as evidenced by significant improvements in sleep quality, pain intensity, and PGIC. More research is needed to comprehensively evaluate the impact of cannabinoids on sleep health and analgesic efficacy.

PROSPERO registration number

CRD42017074255.
Anyonic topological order in twisted equivariant differential (TED) K-theory
Authors: Sati Hisham , Schreiber Urs
Published: December 2022

While the classification of noninteracting crystalline topological insulator phases by equivariant K-theory has become widely accepted, its generalization to anyonic interacting phases — hence to phases with topologically ordered ground states supporting topological braid quantum gates — has remained wide open.

On the contrary, the success of K-theory with classifying noninteracting phases seems to have tacitly been perceived as precluding a K-theoretic classification of interacting topological order; and instead a mix of other proposals has been explored. However, only K-theory connects closely to the actual physics of valence electrons; and self-consistency demands that any other proposal must connect to K-theory.

Here, we provide a detailed argument for the classification of symmetry protected/enhanced [Formula: see text]-anyonic topological order, specifically in interacting 2d semi-metals, by the twisted equivariant differential (TED) K-theory of configuration spaces of points in the complement of nodal points inside the crystal’s Brillouin torus orbi-orientifold.

We argue, in particular, that : (1) topological 2d semi-metal phases modulo global mass terms are classified by the flat differential twisted equivariant K-theory of the complement of the nodal points; (2) [Formula: see text]-electron interacting phases are classified by the K-theory of configuration spaces of [Formula: see text] points in the Brillouin torus; (3) the somewhat neglected twisting of equivariant K-theory by “inner local systems” reflects the effective “fictitious” gauge interaction of Chen, Wilczeck, Witten and Halperin (1989), which turns fermions into anyonic quanta; (4) the induced [Formula: see text]-anyonic topological order is reflected in the twisted Chern classes of the interacting valence bundle over configuration space, constituting the hypergeometric integral construction of monodromy braid representations.

A tight dictionary relates these arguments to those for classifying defect brane charges in string theory [H. Sati and U. Schreiber, Anyonic defect branes in TED-K-theory, arXiv:2203.11838], which we expect to be the images of momentum-space [Formula: see text]-anyons under a nonperturbative version of the AdS/CMT correspondence.
C∗-extreme points of entanglement breaking maps
Authors: Rajarama Bhat B. V. , Devendra Repana , Mallick Nirupama , Sumesh K.
Published: December 2022

In this paper, we study the [Formula: see text]-convex set of unital entanglement breaking (EB-)maps on matrix algebras. General properties and an abstract characterization of [Formula: see text]-extreme points are discussed. By establishing a Radon–Nikodym-type theorem for a class of EB-maps we give a complete description of the [Formula: see text]-extreme points. It is shown that a unital EB-map [Formula: see text] is [Formula: see text]-extreme if and only if it has Choi-rank equal to [Formula: see text]. Finally, as a direct consequence of the Holevo form of EB-maps, we derive a non-commutative analog of the Krein–Milman theorem for [Formula: see text]-convexity of the set of unital EB-maps.
Driver Drowsiness EEG Detection Based on Tree Federated Learning and Interpretable Network
Authors: Qin Xue , Niu Yi , Zhou Huiyu , Li Xiaojie , Jia Weikuan , Zheng Yuanjie
Published: December 2022

Accurate identification of driver’s drowsiness state through Electroencephalogram (EEG) signals can effectively reduce traffic accidents, but EEG signals are usually stored in various clients in the form of small samples. This study attempts to construct an efficient and accurate privacy-preserving drowsiness monitoring system, and proposes a fusion model based on tree Federated Learning (FL) and Convolutional Neural Network (CNN), which can not only identify and explain the driver’s drowsiness state, but also integrate the information of different clients under the premise of privacy protection. Each client uses CNN with the Global Average Pooling (GAP) layer and shares model parameters. The tree FL transforms communication relationships into a graph structure, and model parameters are transmitted in parallel along connected branches of the graph. Moreover, the Class Activation Mapping (CAM) is used to find distinctive EEG features for representing specific classes. On EEG data of 11 subjects, it is found that this method has higher average accuracy, F1-score and AUC than the traditional classification method, reaching 73.56%, 73.26% and 78.23%, respectively. Compared with the traditional FL algorithm, this method better protects the driver’s privacy and improves communication efficiency.
Clay-based cementitious nanofluid flow subjected to Newtonian heating
Authors: Anwar M. S. , Hussain M. , Hussain Z. , Puneeth V. , Irfan M.
Published: December 2022

In recent years, a novel technique for producing robust cementitious materials, called nanocomposites, has emerged. These materials are comprised of clay minerals and polymers. As a result, a vertical flat plate has been used to evaluate a clay-based cementitious nanofluid in this research. The impacts of first-order chemical reactions, heat generation/heat absorption, and the Jeffrey fluid model are taken into account for the study of flow. Newtonian heating and the conditions for slippage velocity have also been considered. The mathematical problem for the flow analysis has been established in relations of partially coupled partial differential equations and the model has been generalized using constant proportional Caputo (CPC) fractional derivative. The problem is solved using the Laplace transform technique to provide precise analytical solutions. On the concentration, temperature, and velocity fields, the physics of a number of crucial flow parameters have been examined graphically. The acquired results have been condensed to a very well-known published work to verify the validity of the current work. It is important to note here that the rate of heat transfer in the fluid decreases by 10.17% by adding clay nanoparticles, while the rate of mass transfer decrease by 1.31% when the value of [Formula: see text] reaches 0.04.
The generalized higher-order nonlinear Schrödinger equation: Optical solitons and other solutions in fiber optics
Authors: Younas Usman , Baber M. Z. , Yasin M. W. , Sulaiman T. A. , Ren Jingli
Published: December 2022

In this study, generalized higher-order nonlinear Schrödinger equation is under consideration analytically. This equation is used in the field of slowly varying envelope of the electric field in the optical fiber with self-phase modulation, third-order dispersion, self-steepening and stimulated Raman scattering. For the sake of optical solitons and other solutions, we use two methods such as generalized exponential rational function (GERFM) and Sardar subequation method (SSEM). The solutions are gained in different forms such as bright, dark, singular, combo solitons, as well as hyperbolic, trigonometric and rational solutions. Some of the acquired wave solutions are characterized graphically in 3D, contour forms and 2D shapes to illustrate the dynamical behavior. A comparable analysis of this study with the available consequences in literature confirms the innovation and assortment of present accomplished wave solutions and hence enhances the great performance of the employed techniques. The offered method can be utilized to assist complicated models applicable to a wide variety of physical situations. We hope that a wide spectrum of engineering model professionals will find this study to be beneficial.
Quantum signature based on multi-arbitrators and product states
Authors: Xin Xiangjun , Zhang Tianyuan , Yang Qinglan , Li Chaoyang
Published: December 2022

In this paper, based on multi-arbitrators and the product states, a new quantum signature scheme (QSS) is proposed. In our scheme, two arbitrators are used to share private keys with the signer. The signer encodes the bit message into orthogonal product states, which are locally indistinguishable. Then, to produce the signature, the signer signs the product states with the key-controlled Hadamard operator and Y operator. Our scheme has the good virtues as follows. First, our signature not only has the security property of unforgeability, but also has the property of strong non-repudiation. Second, when signing a message and verifying a signature, the partners do not need to prepare or transmit any entangled particle. Third, the partners do not need to perform the state comparison algorithm. Fourth, the signer does not need to share any private key with the signature verifier. For our scheme, the signer only shares two private keys with the arbitrators. At last, in our scheme, the repudiation can be flexibly solved. Compared with the other schemes with semi-trusted arbitrator, ours has better performances in security, practicability and efficiency.
Synthesis and physico-chemical studies of alloys of the As2Se3–CuCr2Te4 system and properties of the obtained composite materials
Authors: Aliyev I. I. , Ismailova S. Sh. , Rzayev R. M. , Mamedov A. N. , Gashimov Kh. M. , Karimova N. K.
Published: December 2022

Alloys of the As2Se3–CuCr2Te4 system were synthesized in a wide range of concentrations, and their physico-chemical properties were studied by differential thermal analysis (DTA), X-ray diffraction (XRD), microstructural (MSA) analysis, as well as by determining the microhardness and density, and its [Formula: see text]–[Formula: see text] phase diagram was constructed. It has been established that the phase diagram of the As2Se3–CuCr2Te4 system is quasi-binary of the eutectic type. The system has small single-phase fields based on the original components. In the As2Se3–CuCr2Te4 system, the area of the solid solution based on the As2Se3 compound at room-temperature is 2 mol%, and the area of the solid solution based on the CuCr2Te4 compound is 6 mol%. Joint crystallization of As2Se3 and CuCr2Te4 ends at the double eutectic point with a composition of 15 mol% CuCr2Te4. With slow cooling in the As2Se3–CuCr2Te4 system based on As2Se3, the glass formation region reaches 10 mol% CuCr2Te4. The magnetic properties of the obtained solid solutions (CuCr2Te[Formula: see text](As2Se[Formula: see text] ([Formula: see text]–0.03; 0.05) were studied.
An Integrated XI-UNet for Accurate Retinal Vessel Segmentation
Authors: Aruna Vinodhini C. , Sabena S.
Published: December 2022

Segmentation of blood vessels captured using a fundus camera is the cornerstone for the medical examination of several retinal vascular disorders. In recent research studies, vessel segmentation models focus on deep neural learning. To overlook the segmentation of the toughest retinal vessels like thin vessels, a new neural network architecture is developed based on U-Net integrated with the idea of depth-wise separable convolution and the Inception network incorporated with the sparsity of information. The developed XI-UNet network is trained and tested on DRIVE, STARE and CHASE_DB1 public datasets. The performance and the achievements of the XI-UNet network are greater compared to the prevalent methods.
ASYMPTOTIC ANALYSIS ABOUT THE PERIODOGRAM OF A GENERAL CLASS OF TIME SERIES MODELS WITH SPECTRAL SUPPORTSON LINES NOT PARALLEL TO THE MAIN DIAGONAL
Authors: SHI LEI , JAIN SHILPI , AGARWAL PRAVEEN , ALTAYED YOUSIF , MOMANI SHAHER
Published: December 2022

The aim of this paper is to make inference about a general class of time series models including fractional Brownian motion. The spectral of these processes is supported on lines not parallel to the diagonal [Formula: see text], [Formula: see text], [Formula: see text], in spectral square [Formula: see text], and this class includes stationary, cyclostationary, almost cyclostationary time series and specially fractional Brownian motions. First, the periodogram of these processes is defined and auxiliary operator is applied to explore the distribution of the periodogram. Then the asymptotical estimation for the spectral density function is proposed and asymptotical Wishart function is found. Finally, the validity of the theoretical results is studied using simulated data sets.
SCALING DETECTION IN EXTRACHROMOSOMAL DNA
Authors: JAROSZEWICZ SEBASTIAN , MARIANI MARIA C. , TWENEBOAH OSEI K. , BECCAR-VARELA MARIA P.
Published: December 2022

In this work, we study the statistical correlations in mitochondrial and chloroplastid genomes using the diffusion entropy analysis method and estimate the value of the Hurst exponent using the detrended fluctuation analysis. We compare the scaling exponents of both methods for three sets of genomes: mitochondrial DNA from organisms belonging to the plantae and animalia kingdoms and chloroplast DNA. We find that a wide variety of behaviors depart from the Lévy statistics previously proposed for DNA sequences.
ZAGREB ECCENTRICITY INDICES OF VICSEK NETWORKS
Authors: ZENG QINGCHENG , XI LIFENG
Published: December 2022

For a connected graph, the first Zagreb eccentricity index is defined as the sum of squares of the eccentricities of the vertices, and the second Zagreb eccentricity index is defined as the sum of the products of the eccentricities of pairs of adjacent vertices. In this paper, by using the self-similarity, we compute the first and second Zagreb eccentricity indices of Vicsek network.
COMPLEXITY-BASED ANALYSIS OF HEART RATE VARIABILITY DURING AGING
Authors: DAWI NORAZRYANA MAT , MARESOVA PETRA , NAMAZI HAMIDREZA
Published: December 2022

One of the important areas of heart research is investigating how heart activity changes during aging. In this research, we employed complexity-based techniques to analyze how heart activity varies based on the age of subjects. For this purpose, the heart rate variability (HRV) of 54 healthy subjects (30 M, 24 F, 28.5–76 years old) in three different age groups was analyzed using fractal theory, sample entropy, and approximate entropy. We showed that the fractal dimension, sample entropy, and approximate entropy of the RR interval time series (as HRV) are related to the age of the subjects. In other words, as subjects get older, the complexity of their RR interval time series decreases. Therefore, we decoded the variations in HRV during aging. The method of analysis that was employed in this research can be used to analyze the variations of other physiological signals (e.g. Electroencephalogram (EEG) signals) during aging.
Vibration Control of Irregular Bridges Using Spatially Distributed TMD-Type Counterweights
Authors: Li Zhenchuan , Xu Kun , Ma Ruisheng , Fang Genshen , Han Qiang
Published: December 2022

This paper proposes using spatially distributed TMD-type counterweights for the multiple-mode vibration control of irregular bridges subjected to wind loads. In particular, the governing equations of the bridge with TMD-type counterweights that are spatially distributed at any transverse and/or longitudinal positions of the bridge girder are established. Four objective functions are formulated and compared, and an optimum design method is developed to obtain the optimal design parameters of the TMD-type counterweights for each objective. Subsequently, an irregular cable-stayed bridge equipped with counterweight blocks is chosen as the prototype to demonstrate the control effectiveness of TMD-type counterweights. The results show that the proposed method is feasible for the multiple-mode vibration control of irregular bridges, and TMD-type counterweights show good control efficiency and robustness performance, providing an attractive alternative to traditional counterweights in the vibration control, especially multiple-mode vibration control, of irregular bridges.
A Simple Non-Conforming Isogeometric Formulation with Superior Accuracy for Free Vibration Analysis of Thin Beams and Plates
Authors: Lin Zhiwei , Wang Dongdong , Wu Zhenyu , Yu Jiakang
Published: December 2022

A set of non-conforming quadratic basis functions is introduced to formulate the mass and stiffness matrices that enable a superior frequency accuracy for isogeometric free vibration analysis of thin beams and plates. The non-conforming basis functions are expressed as a simple combination of the original basis functions and their second-order derivatives with an adjustable parameter. By construction, these quadratic non-conforming basis functions only affect the mass matrices and do not alter the stiffness matrices. The adjustable parameter arising from the non-conforming basis functions are determined through optimizing the frequency accuracy. In the case of thin beams, the proposed non-conforming isogeometric formulation leads to an increase of frequency accuracy order or superconvergence. For thin plates, the frequency error of the proposed method is guaranteed to be no larger than that of the standard isogeometric approach. Numerical results for thin beams and plates consistently verify that the proposed formulation with non-conforming basis functions is quite robust and produces very favorable frequency accuracy for both uniform and non-uniform meshes.
The Hochschild Cohomology of the Chinese Monoid Algebra
Authors: Alhussein Hassan
Published: December 2022

In this work we find the groups of Hochschild cohomologies for the Chinese monoid algebra and derive its Hilbert and Poincaré series. In order to obtain this result we construct the Anick resolution via the algebraic discrete Morse theory and Gröbner–Shirshov basis for the Chinese monoid.
Preparation and structural characterization of 4-pyridylboron-capped iron(II) clathrochelates and their chemical transformations into hybrid metallo(IV)-phthalocyaninatoclathrochelate derivatives
Authors: Dudkin Semyon V. , Chuprin Alexander S. , Belova Svetlana A. , Zelinskii Genrikh E. , Vologzhanina Anna V. , Voloshin Yan Z.
Published: December 2022

Mixed boron,antimony-capped iron(II) tris-dioximate monoclathrochelates and their hybrid phthalocyaninatoclathrochelate derivatives, the molecules of which are decorated with the single N-donor 4-pyridyl group, were obtained using two different approaches, such as (i) a transmetallation (a capping group exchange) reaction of their antimony-capped macrobicyclic precursors, and (ii) the direct template condensation of the [Formula: see text] ion as a matrix. The obtained complexes were characterized using elemental analysis, 1H and [Formula: see text]C{1H} NMR, MALDI-TOF MS, and UV–vis spectra, and by the single-crystal X-ray diffraction experiments. Solution UV-vis spectra of 4-pyridyl-terminated iron(II) phthalocyaninatoclathrochelates can be described as a superposition of the spectrum of its metallocomplex precursor MIVPc and that of the iron(II)-encapsulating semiclathrochelate fragment. As follows from the X-ray diffraction data for the hybrid hafnium(IV)-capped tris-dimethylglyoximate pthalocyaninatoclathrochelate and its macrobicyclic boron,antimony-capped precursor, their [Formula: see text]-coordination polyhedra possess the geometry close to intermediate between a trigonal prism (TP) and a trigonal antiprism with the distortion angles [Formula: see text] of 20–30∘. Due to a non-equivalence of their capping fragments, it can be also described as a distorted truncated trigonal pyramid. [Formula: see text]-coordination polyhedron in the hybrid complex possesses the geometry of a capped TP. 4-Pyridylboron-capped pthalocyaninatoclathrochelates are proposed as prospective monodentate N-donor 3D-ligands for the design of various clathrochelate-based coordination assemblies, polytopic and polynuclear systems.
Ion-pairing assemblies comprising porphyrin–AuIII complexes and helical π-system–anion complexes
Authors: Tanaka Hiroki , Haketa Yohei , Maeda Hiromitsu
Published: December 2022

Ion pairs of tetraphenylporphyrin–Au[Formula: see text] complex as a [Formula: see text]-electronic cation with helical [Formula: see text]-electronic receptor–anion complexes were prepared. In the crystalline-state ion-pairing assemblies, the receptor–anion complexes exhibited single-helical structures based on the [1+1]-type Cl[Formula: see text]complexes. [Formula: see text]–[Formula: see text] Interactions, mainly consisting of electrostatic and dispersion forces, effectively induced the ordered arrangement of [Formula: see text]-electronic cation and helical pseudo-[Formula: see text]-electronic anions.
Synthesis and coordination of a dipyrrin appended N-confused porphyrin
Authors: Yang Zhen , Baryshnikov Glib , Sha Feng , Li Chengjie , Wu Xinyan , Ågren Hans , Xie Yongshu , Li Qizhao
Published: December 2022

A hexapyrrane P6 with a terminal N-confused pyrrole was synthesized by acid-catalyzed [3+3] condensation followed by oxidation with DDQ, which did not afford the expected N-confused hexaphyrin. In stead, a rearranged product, i.e., [Formula: see text]-dipyrrin appended N-confused porphyrin 1 was obtained in a yield of 46%. Chelation of 1 with Pt(II) afforded the peripheral complex 1-Pt, which was further coordinated with Rh(I) in the cavity to afford the corresponding bimetallic complex 1-Pt-Rh. Both 1-Pt and 1-Pt-Rh exhibit split Soret-like bands and noticeable Q-like bands tailing to the NIR region up to ca. 1200 nm. Single crystal X-ray diffraction analyses of 1 and 1-Pt revealed that the peripheral coordination of Pt(II) slightly modifies the interplanar angle between the porphyrin macrocycle and the dipyrrin unit, which may modulate the absorption spectra. The results of this work compose an interesting example of synthesizing porphyrinoids appended with conjugated peripheral chains by the oxidative ring closure reaction of an oligopyrrane containing a terminal N-confused pyrrole, and such compounds may be used for both inner and peripheral coordination to afford complexes with tunable NIR absorption.
Light field microscopy in biological imaging
Authors: Yi Chengqiang , Zhu Lanxin , Li Dongyu , Fei Peng
Published: December 2022

Light field microscopy (LFM), featured for high three-dimensional imaging speed and low phototoxicity, has emerged as a technique of choice for instantaneous volumetric imaging. In contrast with other scanning-based three-dimensional (3D) imaging approaches, LFM enables to encode 3D spatial information in a snapshot manner, permitting high-speed 3D imaging that is only limited by the frame rate of the camera. In this review, we first introduce the fundamental theory of LFM and current corresponding advanced approaches. Then, we summarize various applications of LFM in biological imaging.
Heisenberg-type uncertainty principles for the Dunkl–Weinstein transform
Authors: Soltani Fethi , Maktouf Ibrahim , Nefzi Walid
Published: December 2022

Let [Formula: see text], and let [Formula: see text], [Formula: see text], the Lebesgue spaces associated with the Dunkl–Weinstein operator [Formula: see text]. In this paper, we prove Heisenberg-type uncertainty inequalities for the Dunkl–Weinstein transform [Formula: see text] on [Formula: see text]; specifically, we establish a local-type uncertainty inequality for the Dunkl–Weinstein transform [Formula: see text], and we deduce Heisenberg-Pauli-Weyl-type inequality for this transform on [Formula: see text]. Next, we prove Clarkson-type and Nash-type inequalities for the Dunkl–Weinstein transform [Formula: see text] on [Formula: see text]. Finally, by combining these inequalities, we show Laeng–Morpurgo-type uncertainty inequalities for [Formula: see text] on [Formula: see text].
On behaviors of porous shape memory polymer under different loading conditions
Authors: Zhou Rui , Li Biao , Zhang Fangfang , Yang Li
Published: December 2022

Shape memory polymer (SMP) has drawn much attention in the fields of aerospace, microsystems and biomedicine as a typical smart material with unique shape memory properties. The porous SMPs (P-SMPs) have been manufactured for the applications of reduce noise and insulate thermal. A constitutive model of P-SMPs that proposed based on phase transition theory has been investigated in this work. First, combining Mori–Tanaka method and phase transition theory, a modified micromechanics constitutive model of P-SMPs has been presented to describe the thermal-mechanical behavior of P-SMPs. Then, a series of experiments including uniaxial tension, stress relaxation and thermal cycling test have been conducted to determine the parameters of the modified constitutive model. Finally, the correctness of the proposed constitutive model has been verified by comparing the results of the thermodynamic cycle process including heating recovery and cooling loading stages obtained by the numerical simulation results and thermodynamic cycle experiment. The results show that with a porosity f = 0.1, the strain and stress mean square errors of the constitutive model based on the phase transition theory are 0.22 and 0.0102, respectively, which means that the constitutive model proposed based on phase transition theory can reflect the shape memory properties of P-SMP materials.
On study of the coupled system of nonlocal fractional q-integro-differential equations
Authors: Ibrahim Amira Abd-Elall , Zaghrout Afaf A. S. , Raslan K. R. , Ali Khalid K.
Published: December 2022

In this paper, we introduce a coupled system of nonlocal fractional q-integro-differential equations. Under certain assumptions, we prove the existence and uniqueness of solutions for a coupled system of fractional q-integro-differential equations. We also study continuous dependence. We solve this system numerically using the finite–Simpson’s and cubic spline–Simpson’s methods. Finally, three examples are provided to demonstrate the efficacy of the methods employed.
Techno-economic analysis of coupling wind-powered green hydrogen production with geological storage
Authors: Schwartz Brandon A. , Menefee Anne H.
Published: December 2022

The intermittent nature of wind power creates mismatches between electricity supply and demand, limiting its penetration in modern electricity grids. In this study, we explore the techno-economic potential to balance grid loads by coupling wind power generation with hydrogen (H
2
) production and underground storage. For a hypothetical 1 GW electricity market, we compare costs and logistics of wind power with and without coupled H
2
storage in three leading underground storage options: salt caverns, lined rock caverns, and depleted oil and gas reservoirs. We calculate rates of return (ROR) for a 30-year facility lifetime based on 12 320 scenarios that span the full range of project variables, including cavern size, cavern installation costs, cost of hydrolysis, transmission costs, production tax credit, and compression costs. The model is built from the perspective of a hypothetical wind power producer that owns and operates the storage facility and is large enough to sell directly to end users, such that electricity sale prices can be assumed to be in the retail range. The model does not include infrastructure and maintenance costs for a hydrogen transmission network. Therefore, the model is not an optimization of an entire energy system, but rather is optimized for a large entity (a utility) within an energy system under the assumption of constant parameters. The results suggest that coupled H
2
production and storage can increase wind power capacity factors from an average of 0.38 to 0.62 without any loss of wind power generation, or a 40% increase relative to typical capacity factors without H
2
storage. Coupled H
2
storage can also increase a wind farm's ROR from
c.
8% to over 15% over a 30-year project lifetime, where underground storage in salt caverns provides the greatest potential ROR increase. We also consider different project financing scenarios and find that subsidizing H
2
storage is more effective in improving wind power economics than existing production tax credits, which suggests that understanding and reducing underground storage costs has greater potential to expand wind power penetration than measures focused explicitly on incentivizing wind power production itself.
Numerical assessments of the effects of injected air temperature and well configuration on the cycle performance in compressed air energy storage in aquifers
Authors: Yang Lichao , Cai Zuansi , Li Cai , Guo Chaobin , He Qingcheng
Published: December 2022

Aquifers have advantages over salt caverns as the vessels for compressed air energy storage due to their wider availability for suitable sites and lower one-off capital investment for construction. We conducted numerical simulations for compressed air energy storage in aquifers (CAESA) to investigate the effects of injected air temperature, the number of injection/production wells and their configurations on cycle performance, based on the data from the Pittsfield CAESA test. The results show that injected air temperature has a negligible effect on the overall energy recovery efficiency, but a higher injected air temperature leads to a higher energy storage capacity. A multiple-injection/production-well arrangement can achieve a larger storage capacity than single-well systems. The distance between the injection/withdrawal wells will affect the storage capacity. This suggests that for a multiple-well CAESA system, a comprehensive modelling study should be used for the optimal system design to achieve the most desirable storage capacity.