bluuebunny/crossref_metadata_2025 huggingface dataset:
Nanoemulsion of Lavandula angustifolia Essential Oil/Gold Nanoparticles: Antibacterial Effect against Multidrug-Resistant Wound-Causing Bacteria
Authors: Fadel Balqis A. , Elwakil Bassma H. , Fawzy Esraa E. , Shaaban Marwa M. , Olama Zakia A.
Published: October 2023

Hospitalized patients are severely impacted by delayed wound healing. Recently, there has been a growing focus on enhancing wound healing using suitable dressings. Lavandula angustifolia essential oil (LEO) showed potential antibacterial, anti-inflammatory, and wound healing properties. However, the prepared gold nanoparticles possessed multifunctional properties. Consequently, the present investigation aimed to synthesize a novel nanosystem consisting of nano-Lavandula angustifolia essential oil and gold nanoparticles prepared through ultrasonic nanoemulsifying techniques in order to promote wound healing and combat bacterial infection. LEO showed potent antibacterial activity against Klebsiella pneumoniae, MRSA and Staphylococcus aureus with minimum inhibitory concentration (MIC) values of 32, 16 and 16 µg/mL, respectively, while exhibiting low activity against Proteus mirabilis. Interestingly, the newly formulated nano-gold/nano-Lavandula angustifolia penetrated the preformed P. mirabilis biofilm with a full eradication of the microbial cells, with MIC and MBEC (minimal biofilm eradication concentration) values reaching 8 and 16 µg/mL, respectively. The cytotoxic effect of the novel nanoformula was also assessed against WI-38 fibroblasts vero (normal) cells (IC50 = 0.089 mg/mL) while nano-gold and nano-Lavandula angustifolia showed higher results (IC50 = 0.529, and 0.209 mg/mL, respectively). Nano-gold/nano-Lavandula angustifolia formula possessed a powerful wound healing efficacy with a 96.78% wound closure. These findings revealed that nano-gold/nano-Lavandula angustifolia nanoemulsion can inhibit bacterial growth and accelerate the wound healing rate.
Preparation of Cellulose-Based Activated Carbon Fibers with Improved Yield and Their Methylene Chloride Adsorption Evaluation
Authors: Jeong Jin-Soo , Kim Byung-Joo
Published: October 2023

The recent rapid growth of the battery industry has led to a rapid increase in methylene chloride emissions. Methylene chloride causes health and social problems in humans. In this study, cellulose-based activated carbon fibers (CACFs) with improved yield were prepared for the removal of methylene chloride. The concentration of ammonium phosphate in the pretreatment controlled the crosslink density of cellulose fibers and improved the yield. From the results, the specific surface area and total pore volume of cellulose-based activated carbon fibers pretreated with ammonium phosphate (AP-CACFs) were determined to be 1920–2060 m2/g and 0.83–1.02 cm3/g, respectively, and the total yield improved by 6.78–11.59% compared to that of CACFs (4.97%). In particular, a correlation between the textural properties of CACFs and methylene chloride adsorption/desorption behavior was obtained. This correlation can be used to develop efficient adsorbents for methylene chloride removal.
Bioactive Glasses Containing Strontium or Magnesium Ions to Enhance the Biological Response in Bone Regeneration
Authors: Gavinho Sílvia Rodrigues , Pádua Ana Sofia , Holz Laura Isabel Vilas , Sá-Nogueira Isabel , Silva Jorge Carvalho , Borges João Paulo , Valente Manuel Almeida , Graça Manuel Pedro Fernandes
Published: October 2023

The non-surgical treatments are being required to reconstruct damaged tissue, prioritizing our body’s natural healing process. Thus, the use of bioactive materials such as bioactive glass has been studied to support the repair and restoration of hard and soft tissue. Thus, in this work Bioglass 45S5 was developed, adding 1 and 2%mol of SrO or MgO and the physical and biological properties were evaluated. The addition of MgO and SrO at the studied concentrations promoted the slight increase in non-bridging oxygens number, observed through the temperature shift in phase transitions to lower values compared to Bioglass 45S5. The insertion of the ions also showed a positive effect on Saos-2 cell viability, decreasing the cytotoxic of Bioglass 45S5. Besides the Ca/P ratio on the pellets surface demonstrating no evidence of higher reactivity between Bioglass 45S5 and Bioglass with Sr and Mg, micrographs show that at 24 h the Ca/P rich layer is denser than in Bioglass 45S5 after the contact with simulated body fluid. The samples with Sr and Mg show a higher antibacterial effect compared to Bioglass 45S5. The addition of the studied ions may benefit the biological response of Bioglass 45S5 in dental applications as scaffolds or coatings.
Shape-Driven Response of Gold Nanoparticles to X-rays
Authors: Tarantino Simona , Capomolla Caterina , Carlà Alessandra , Giotta Livia , Cascione Mariafrancesca , Ingrosso Chiara , Scarpa Edoardo , Rizzello Loris , Caricato Anna Paola , Rinaldi Rosaria , De Matteis Valeria
Published: October 2023

Radiotherapy (RT) involves delivering X-ray beams to the tumor site to trigger DNA damage. In this approach, it is fundamental to preserve healthy cells and to confine the X-ray beam only to the malignant cells. The integration of gold nanoparticles (AuNPs) in the X-ray methodology could be considered a powerful tool to improve the efficacy of RT. Indeed, AuNPs have proven to be excellent allies in contrasting tumor pathology upon RT due to their high photoelectric absorption coefficient and unique physiochemical properties. However, an analysis of their physical and morphological reaction to X-ray exposure is necessary to fully understand the AuNPs’ behavior upon irradiation before treating the cells, since there are currently no studies on the evaluation of potential NP morphological changes upon specific irradiations. In this work, we synthesized two differently shaped AuNPs adopting two different techniques to achieve either spherical or star-shaped AuNPs. The spherical AuNPs were obtained with the Turkevich–Frens method, while the star-shaped AuNPs (AuNSs) involved a seed-mediated approach. We then characterized all AuNPs with Transmission Electron Microscopy (TEM), Uv-Vis spectroscopy, Dynamic Light Scattering (DLS), zeta potential and Fourier Transform Infrared (FTIR) spectroscopy. The next step involved the treatment of AuNPs with two different doses of X-radiation commonly used in RT, namely 1.8 Gy and 2 Gy, respectively. Following the X-rays’ exposure, the AuNPs were further characterized to investigate their possible physicochemical and morphological alterations induced with the X-rays. We found that AuNPs do not undergo any alteration, concluding that they can be safely used in RT treatments. Lastly, the actin rearrangements of THP-1 monocytes treated with AuNPs were also assessed in terms of coherency. This is a key proof to evaluate the possible activation of an immune response, which still represents a big limitation for the clinical translation of NPs.
A Review of Fluid Energy Converters Based on Triboelectric Nanogenerators: Performance Analysis from Energy Conversion
Authors: Li Qianying , Xi Yi
Published: October 2023

In recent years, the development of the Internet of Things has challenged traditional energy supply methods. Suddenly rising maintenance costs and serious environmental pollution have led to great concern over energy supply methods such as wired transmission and batteries. Fluid energy is a kind of clean energy widely existing in nature, which can effectively reduce costs and environmental pollution. In the field of collecting fluid energy, fluid energy converters based on triboelectric nanogenerators (FEC-TENGs) have always been a research hotspot. This paper reviews the latest research progress of FEC-TENGs. Firstly, the basic working principle and working mode of FEC-TENGs are introduced. Then, the theoretical process and application examples of converting fluid energy into electrical energy or electrical signals are analyzed in detail. According to the calculation process of energy conversion efficiency and the performance evaluation parameters, the structural design, performance output, and application fields of FEC-TENGs are summarized. Finally, this paper points out the challenges and shortcomings of the current FEC-TENGs and provides our views on the future development of this field.
Altered Expression of Vitamin D Metabolism Genes and Circulating MicroRNAs in PBMCs of Patients with Type 1 Diabetes: Their Association with Vitamin D Status and Ongoing Islet Autoimmunity
Authors: Al-Nakhle Hakeemah , Mohsen Ihsan , Elnaem Bashir , Alharbi Abdullah , Alnakhli Ibtisam , Almoarfi Shareefa , Fallatah Jameela
Published: October 2023

Background: The immunomodulatory role of 1,25-Dihydroxy vitamin D3 (1,25(OH)2D3) is exerted through its interaction with the vitamin D receptor (VDR) present on pancreatic and immune cells. While a deficiency in vitamin D has been linked to Type 1 Diabetes Mellitus (T1DM), the exact molecular mechanism driving this down-regulation in T1DM is yet to be fully understood. This study aimed to decipher differences in the expression of genes associated with vitamin D metabolism in T1DM patients and to ascertain if there is a correlation between serum 1,25(OH)2D3 levels and the expression of these genes. We also sought to understand the influence of specific microRNAs (miRNAs) on the expression of vitamin D metabolism genes in peripheral blood mononuclear cells (PBMCs) of T1DM patients. Furthermore, the study delved into the potential implications of altered vitamin D metabolism genes and miRNAs on autoimmune processes. Methods: Utilizing real-time PCR, we assessed the expression profiles of genes encoding for 1-hydroxylases (CYP27B1) and 24-hydroxylases (CYP24A1), as well as related miRNAs, in PBMCs from 30 T1DM patients and 23 healthy controls. ELISA tests facilitated the measurement of 1,25(OH)2D3, GAD65, and IA-2 levels. Results: Our findings showcased downregulated CYP27B1 mRNA levels, while CYP24A1 expression remained stable compared to healthy subjects (CYP27B1, p = 0.0005; CYP24A1, p = 0.205, respectively). In T1DM patients, the levels of has-miR-216b-5p were found to be increased, while the levels of has-miR-21-5p were decreased in comparison to the control group. Notably, no correlation was identified between the expression of CYP27B1 in T1DM patients and the levels of has-miR-216b-5p, has-miR-21-5p, and 1,25(OH)2D3. A significant negative correlation was identified between CYP27B1 mRNA levels in PBMCs of T1DM and IA2, but not with GAD65. Conclusions: The study highlights there were reduced levels of both CYP27B1 mRNA and has-miR-21-5p, along with elevated levels of has-miR-216b-5p in the PBMCs of T1DM. However, the absence of a correlation between the expression of CYP27B1, levels of has-miR-216b-5p, and the status of 1,25(OH)2D3 suggests the possible existence of other regulatory mechanisms. Additionally, the inverse relationship between IA2 autoantibodies and CYP27B1 expression in T1DM patients indicates a potential connection between this gene and the autoimmune processes inherent in T1DM.
Dietary Inflammatory Potential and Bone Outcomes in Midwestern Post-Menopausal Women
Authors: Jackson Mariah Kay , Bilek Laura D. , Waltman Nancy L. , Ma Jihyun , Hébert James R. , Price Sherry , Graeff-Armas Laura , Poole Jill A. , Mack Lynn R. , Hans Didier , Lyden Elizabeth R. , Hanson Corrine
Published: October 2023

Little is known about the inflammatory potential of diet and its relation to bone health. This cross-sectional study examined the association between the inflammatory potential of diet and bone-related outcomes in midwestern, post-menopausal women enrolled in the Heartland Osteoporosis Prevention Study (HOPS) randomized controlled trial. Dietary intake from the HOPS cohort was used to calculate Dietary Inflammatory Index (DII®) scores, which were energy-adjusted (E-DIITM) and analyzed by quartile. The association between E-DII and lumbar and hip bone mineral density (BMD) and lumbar trabecular bone scores (TBS; bone structure) was assessed using ANCOVA, with pairwise comparison to adjust for relevant confounders (age, education, race/ethnicity, smoking history, family history of osteoporosis/osteopenia, BMI, physical activity, and calcium intake). The cohort included 272 women, who were predominately white (89%), educated (78% with college degree or higher), with a mean BMI of 27 kg/m2, age of 55 years, and E-DII score of −2.0 ± 1.9 (more anti-inflammatory). After adjustment, E-DII score was not significantly associated with lumbar spine BMD (p = 0.53), hip BMD (p = 0.29), or TBS at any lumbar location (p > 0.05). Future studies should examine the longitudinal impact of E-DII scores and bone health in larger, more diverse cohorts.
Determinants of Z-Score of Bone Mineral Density among Premenopausal Saudi Females in Different Age Groups: A Cross Sectional Study
Authors: Sultan Intessar , Taha Inass , El Tarhouny Shereen , Mohammed Rehab A. , Allah Azza M. Abdu , Al Nozha Omar , Desouky Maha , Ghonimy Abdelrahman , Elmehallawy Yara , Aldeeb Nawaf , Iskandarani Yara Ayman
Published: October 2023

This is a comparative multicenter cross-sectional study that evaluated the potential determinants of Z-scores among premenopausal Saudi women before and after the age of peak bone density. The Study concluded that for better BMD among premenopausal women, attention should be paid to early physical activity and healthy nutrition, especially vitamin D, during the childbearing period. Objective: To explore the potential determinants of Z-scores among premenopausal Saudi females in different age groups before and after the expected age of peak bone density (PBD). Methods: This multicenter comparative cross-sectional study was conducted in Madinah and Jeddah, Saudi Arabia, between August 2021 and March 2022. We recruited 886 premenopausal females (605 (68.3%) below and 281 (31.7%) at or above the age of 30). The structured pre-coded Arabic questionnaire included sociodemographic data, a BMD questionnaire, menstrual history, an Arab Teen Lifestyle Study questionnaire, and food frequency data. Metabolic Equivalents (METs) were calculated from physical activity. Analysis of serum PTH, 25(OH) vitamin D (VD) was performed with chemiluminescent immunoassay. BMD was measured with a calcaneal qualitative ultrasound. Results: Most women had age-matched Z-scores, with very few (24 (2.7%)) being non-age-matched with no identified secondary causes. Significant Z-score determinants before PBD were BMI (OR: 0.167, p = 0.003) and total METs (OR: 0.160, p < 0.005). After the age of PBD, significant predictors were parity (OR: 0.340, p = 0.042), history of vitamin D deficiency (OR: 0.352, p = 0.048), and BMI (OR: 0.497, p = 0.019). Conclusions: Early determinants of Z-scores among premenopausal women were the nutritional status and physical activity. After the age of PBD, parity and vitamin D status offer additional determinants. For better BMD, attention should be paid to early physical activity and healthy nutrition, especially for vitamin D, with intensification of efforts during the childbearing period.
A Novel Albumin-Related Nutrition Biomarker Predicts Breast Cancer Prognosis in Neoadjuvant Chemotherapy: A Two-Center Cohort Study
Authors: Wang Meng-Di , Duan Fang-Fang , Hua Xin , Cao Lu , Xia Wen , Chen Jia-Yi
Published: October 2023

Background: Recently, there has been a growing focus on the prognostic significance of nutrition-related biomarkers. We attempted to explore the association between a novel albumin-related nutrition marker called “lymphocyte × albumin (LA)” and disease-free survival (DFS) in breast cancer patients undergoing neoadjuvant chemotherapy (NAC). Methods: In total, 711 non-metastatic breast cancer patients who underwent NAC at two medical centers were retrospectively analyzed. We performed least absolute shrinkage and selection operator (LASSO) Cox regression analysis as well as multivariate Cox regression analyses to identify the variables associated with DFS and to establish a predictive nomogram. Results: The nomogram incorporated four variables based on the multivariate analysis of DFS in the training cohort: LA, ypN stage, ypT stage, and hormone receptor status. In comparison with the traditional TNM staging system, the nomogram demonstrated superior discrimination, calibration ability, and clinical usefulness in both the training set and internal and external validation sets. Furthermore, patients stratified into different risk groups resulted in significant differences in DFS. Conclusions: LA is an independent prognostic biomarker, and LA-based prognostic nomogram offers a more precise assessment of DFS for breast cancer patients treated with NAC, potentially serving as a valuable tool for personalized prognostic predictions.
The Role of Healthy Diet and Lifestyle in Centenarians
Authors: Simoes Eduardo J. , Ramos Luiz R.
Published: October 2023

Life expectancy at birth (hereafter, life expectancy) and longevity are established indicators of population health [...]
Seroepidemiological Survey of Chronic Chagas Disease in a Rural Community in Southern Bahia, Brazil, Using Recombinant Chimeric Antigens
Authors: Soares Neci Matos , Barreto Nilo Manoel Pereira Vieira , Farias Marina Morena Brito , de Lima Oliveira Cíntia , Araújo Weslei Almeida Costa , de Souza Joelma Nascimento , Teixeira Márcia Cristina Aquino , Gonçalves Noilson Lázaro Sousa , Sampaio Daniel Dias , Pavan Tycha Bianca Sabaini , Celedon Paola Alejandra Fiorani , Zanchin Nilson Ivo Tonin , Santos Fred Luciano Neves
Published: October 2023

Chagas disease (CD), caused by the parasite Trypanosoma cruzi, is a neglected tropical disease with life-threatening implications. In this study, we conducted a seroepidemiological survey to determine the prevalence and clinical profiles of CD in 217 individuals from an impoverished rural community in Southern Bahia, Brazil. The overall prevalence of CD in the studied community was 0.92%, detected through latent class analysis (LCA). Two individuals tested positive for anti-T. cruzi IgG, both being male farmers. One case was a 22-year-old man born in Camamu, with no evidence of congenital transmission, suggesting other routes of transmission such as vector-borne transmission due to migratory activities. The other case was a 69-year-old man born in São Felipe, who had lived in an adobe/brick house and had a pacemaker due to cardiac involvement caused by CD. The prevalence in this community was lower than expected, given the socioeconomic conditions and environmental factors that contribute to T. cruzi transmission. This could be attributed to the implementation of preventive measures and vector control programs by the Brazilian Government. However, continuous monitoring and surveillance are essential to sustain control efforts and detect any potential re-emergence of the disease. While the overall prevalence was low, the detection of positive cases underscores the need for continued surveillance and control measures in vulnerable populations, such as rural communities. Active surveillance, early diagnosis, and timely treatment are crucial in preventing disease progression and complications, thereby enhancing the effectiveness of screening and treatment programs.
Evaluating Sex Differences in Efficacy, Safety and Pharmacokinetics in Patients Treated with Cannabis by a Metered-Dose Inhaler
Authors: Aviram Joshua , Glezerman Marek , Hayam Eytan , Belobrov Rostislav , Procaccia Shiri , Meiri David , Eisenberg Elon
Published: October 2023

Background: Clinical studies on medical cannabis (MC) treatment have shown sex-related differences, including higher susceptibility to adverse events among women and greater analgesia among men. Here, we used the Syqe metered-dose inhaler (MDI) and a single chemovar to analyze sex differences. Methods: A total of 1249 Israeli chronic pain patients were assessed for pain intensity, sleep and adverse events (AEs) over 240 days. Results: Following the first two weeks, no significant sex differences were found in the effectiveness or safety of MC treatment (p > 0.05). Inhaled Δ9-THC doses did not vary significantly between sexes (p > 0.05) except in the first month of treatment. Pain reduction and sleep improvement were similar for both sexes (p > 0.05). The overall rate of AEs was equal and relatively low at 10% (n = 65, 10% of women and n = 60, 10% of men; χ2 (1) = 0.05, p = 0.820). A secondary analysis of pharmacokinetic data showed no significant differences between sexes in Δ9-THC and its metabolite pharmacokinetics, cardiovascular measures, or AE severity (p > 0.05). Conclusions: Uniform MC treatment via the Syqe MDI showed no sex differences in short-term effectiveness, safety and pharmacokinetics, nor in long-term effects, under “real-life” conditions. These findings provide insights into MC treatment which may inform clinical practice and policy-making in the field.
Modulation of Neuron and Astrocyte Dopamine Receptors via Receptor–Receptor Interactions
Authors: Guidolin Diego , Tortorella Cinzia , Marcoli Manuela , Cervetto Chiara , De Caro Raffaele , Maura Guido , Agnati Luigi F.
Published: October 2023

Dopamine neurotransmission plays critical roles in regulating complex cognitive and behavioral processes including reward, motivation, reinforcement learning, and movement. Dopamine receptors are classified into five subtypes, widely distributed across the brain, including regions responsible for motor functions and specific areas related to cognitive and emotional functions. Dopamine also acts on astrocytes, which express dopamine receptors as well. The discovery of direct receptor–receptor interactions, leading to the formation of multimeric receptor complexes at the cell membrane and providing the cell decoding apparatus with flexible dynamics in terms of recognition and signal transduction, has expanded the knowledge of the G-protein-coupled receptor-mediated signaling processes. The purpose of this review article is to provide an overview of currently identified receptor complexes containing dopamine receptors and of their modulatory action on dopamine-mediated signaling between neurons and between neurons and astrocytes. Pharmacological possibilities offered by targeting receptor complexes in terms of addressing neuropsychiatric disorders associated with altered dopamine signaling will also be briefly discussed.
Treatments for Ocular Diseases in Pregnancy and Breastfeeding: A Narrative Review
Authors: Demarinis Giuseppe , Tatti Filippo , Taloni Andrea , Giugliano Antonio Valentino , Panthagani Jesse , Myerscough James , Peiretti Enrico , Giannaccare Giuseppe
Published: October 2023

Pregnancy is a medical condition in which the physiological changes in the maternal body and the potential impact on the developing fetus require a cautious approach in terms of drug administration. Individual treatment, a thorough assessment of the extent of the disease, and a broad knowledge of the therapeutic options and different routes of administration of ophthalmic drugs are essential to ensure the best possible results while minimizing risks. Although there are currently several routes of administration of drugs for the treatment of eye diseases, even with topical administration, there is a certain amount of systemic absorption that must be taken into account. Despite continuous developments and advances in ophthalmic drugs, no updated data are available on their safety profile in these contexts. The purpose of this review is both to summarize the current information on the safety of ophthalmic treatments during pregnancy and lactation and to provide a practical guide to the ophthalmologist for the treatment of eye diseases while minimizing harm to the developing fetus and addressing maternal health needs.
Topical Application of Siberian Pine Essential Oil Formulations Enhance Diabetic Wound Healing
Authors: Nikolic Milica , Andjic Marijana , Bradic Jovana , Kocovic Aleksandar , Tomovic Marina , Samanovic Andjela Milojevic , Jakovljevic Vladimir , Veselinovic Mirjana , Capo Ivan , Krstonosic Veljko , Kladar Nebojsa , Petrovic Anica
Published: October 2023

This study aimed to develop novel topical formulations based on a natural component (0.5% of Siberian pine essential oil) and to assess its wound-healing capacity through macroscopic, histopathological, and biochemical examination. The phytochemical profile of Pinus sibirica essential oil (PSEO) and rheological analysis and safety potential of formulations were determined. The wound-healing effect was evaluated on an excision wound model in diabetic Wistar albino rats randomly divided into the following groups topically treated with (1) untreated, (2) 1% silver sulfadiazine, (3) ointment base, (4) gel base, (5) PSEO ointment, and (6) PSEO gel. Formulations containing PSEO were stable and safe for skin application. Three weeks of treatment with both PSEO formulations (ointment and gel) led to a significant reduction in wound size (98.14% and 96.28%, respectively) and a remarkably higher level of total hydroxyproline content (9.69 µg/mg and 7.26 µg/mg dry tissue, respectively) relative to the control group (65.97%; 1.81 µg/mg dry tissue). These findings were in correlation with histopathological results. Topically applied PSEO formulations were associated with a significant reduction in most of the measured pro-oxidants and enhanced activity of the antioxidant defense system enzymes (p < 0.05). Our findings showed that gel and ointment with PSEO demonstrated significant wound-repairing capabilities in the excision wound model.
Integrative Literature Analysis of Holopelagic Sargassum (Sargasso) in the Western Atlantic (2011–2022): Status, Trends, and Gaps
Authors: Arita Julianna T. , Iporac Lowell Andrew R. , Bally Natalie K. , Fujii Mutue T. , Collado-Vides Ligia
Published: October 2023

Since 2011, the Caribbean and Gulf of Mexico coasts have been receiving massive influxes of holopelagic sargasso algae composed of Sargassum natans and Sargassum fluitans. This phenomenon has been causing several negative local impacts, such as ecological disturbances and socioeconomic and health concerns of communities in impacted areas. This work aimed to assess the status of scientific knowledge related to pelagic sargasso, including trends, emphases, and gaps. A literature review was conducted on publications and reports from 2011 to 2022, of which 251 articles were collected based on an inclusion–exclusion criteria. Aspects of each article were quantified, including location, description of sargasso, the type of study, and research theme. A region-wide research emphasis on ecology, remote sensing, and valorization was observed. Areas first affected by the inundations composed a higher percentage of sargasso studies than other locations, and the distribution of studies varied among subregions. Topics requiring further investigation include sargasso’s growth and mortality rates and drivers, taxonomic and physiologic differences among morphotypes, and real-time forecasting resolution at local scales both on and offshore. This research emphasized efforts from the scientific community on research and mitigation initiatives.
Migration Studies and Endocrine Disrupting Activities: Chemical Safety of Cosmetic Plastic Packaging
Authors: Bou-Maroun Elias , Dahbi Laurence , Dujourdy Laurence , Ferret Pierre-Jacques , Chagnon Marie-Christine
Published: October 2023

The endocrine activity and endocrine disruptor (ED) chemical profiles of eleven plastic packaging materials covering five major polymer types (3PET, 1HDPE, 4LDPE, 2 PP, and 1SAN) were investigated using in vitro cell-based reporter-gene assays and a non-targeted chemical analysis using gas chromatography coupled to mass spectrometry (GC-MS). To mimic cosmetic contact, six simulants (acidic, alkaline, neutral water, ethanol 30%, glycerin, and paraffin) were used in migration assays performed by filling the packaging with simulant. After 1 month at 50 °C, simulants were concentrated by Solid Phase Extraction (SPE) or Liquid-Liquid Extraction (LLE). The migration profiles of seven major endocrine disrupting chemicals detected from GC-MS in the different materials and simulants were compared with Estrogen Receptor (ER) and Androgen Receptor (AR) activities. With low extraction of ED chemicals in aqueous simulants, no endocrine activities were recorded in the leachates. Paraffin was shown to be the most extracting simulant of antiandrogenic chemicals, while glycerin has estrogenic activities. Overall, ED chemical migration in paraffin was correlated with hormonal activity. The NIAS 2,4-di-tert-butyl phenol and 7,9-di-tert-butyl1-oxaspiro (4,5) deca-6,9-diene-2,8-dione were two major ED chemicals present in all polymers (principally in PP and PE) and in the highest quantity in paraffin simulant. The use of glycerin and liquid paraffin as cosmetic product simulants was demonstrated to be relevant and complementary for the safety assessment of released compounds with endocrine activities in this integrated strategy combining bioassays and analytical chemistry approaches.
Effect of Salt Concentration on Oil Recovery during Polymer Flooding: Simulation Studies on Xanthan Gum and Gum Arabic
Authors: Olabode Oluwasanmi , Akinsanya Oluwatimilehin , Daramola Olakunle , Sowunmi Akinleye , Osakwe Charles , Benjamin Sarah , Samuel Ifeanyi
Published: October 2023

Oil recoveries from medium and heavy oil reservoirs under natural recovery production are small because of the high viscosity of the oil. Normal water flooding procedures are usually ineffective, as the injected water bypasses much of the oil because of its high mobility. Thermal flooding processes are desirable but have many disadvantages from costs, effects on the environment, and loss of lighter hydrocarbons. Chemical flooding options, such as bio-polymer flooding options, are attractive, as they are environmentally friendly and relatively cheap to deploy and help to increase the viscosity of the injecting fluid, thereby reducing its mobility and increasing its oil recovery. The downside to polymer flooding includes reservoir temperature, salinity, molecular weight, and composition. Six weight percentages of two polymers (xanthan gum, XG, and gum arabic, GA) are dissolved in water, and their viscosity is measured in the laboratory. These viscosities are incorporated with correlations in the Eclipse software to create models with different polymer concentrations of (0.1% wt., 0.2% wt., 0.3% wt., 0.4% wt., 0.5% wt., and 1% wt.). A base case of natural recovery and water injection was simulated to produce an oil recovery of 5.9% and 30.8%, respectively, while at 0.1% wt. and 1% wt., respectively, oil recoveries of 38.8% and 45.7% (for GA) and 48.1% and 49.8% (for XG) are estimated. At 5% and 10% saline conditions, a drop in oil recovery of (4.6% and 5.3%) is estimated during GA flooding and (1.2% and 1.7%) for XG flooding at 1% wt., respectively. XG exhibits higher oil recoveries compared to GA at the same % wt., while oil recoveries during GA floodings are more negatively affected by higher saline concentrations.
Eco Polymeric Materials and Natural Polymer
Authors: Li Jingpeng , Lu Yun , Wang Huiqing
Published: October 2023

With the increasing concern regarding the undesirable environmental and socioeconomic consequences of petrochemicals and limited fossil resources, biomass, bio-based polymers, and other renewable natural resources have increasingly become alternatives for the production of functional materials [...]
Experimental and Analytical Studies on Low-Cost Glass-Fiber-Reinforced-Polymer-Composite-Strengthened Reinforced Concrete Beams: A Comparison with Carbon/Sisal Fiber-Reinforced Polymers
Authors: Rodsin Kittipoom , Ejaz Ali , Hussain Qudeer , Parichatprecha Rattapoohm
Published: October 2023

This study presents an experimental framework with seventeen beams to investigate the impact of loading type, configuration, and through-bolt anchorage on LC-GFRP (Low-Cost Glass-Fiber-Reinforced Polymer) confinement performance. Beams underwent three-point and four-point bending, with LC-GFRP applied in various ways, including U-shaped, side-bonded, and fully wrapped, with and without anchors. The performance of LC-GFRP was compared to CFRP (Carbon-Fiber-Reinforced Polymer) and sisal wraps. LC-GFRP in side-bonded and U-shaped configurations without anchors under three-point bending showed no shear failure, while those under four-point bending without anchors experienced shear failure. With anchors, U-shaped configurations successfully prevented shear failure. The side-bonded, U-shaped, and U-shaped configurations along the full span with anchors demonstrated peak capacity enhancements of 72.11%, 43.66%, and 68.39% higher improvements than the corresponding configurations without anchors, respectively. Wrapping all sides of the beam with LC-GFRP or CFRP prevented shear failure without additional anchors, with complete wrapping being the most efficient method. When anchors were used, significant capacity enhancements were observed. Existing shear strength prediction models were evaluated, highlighting the need for more tailored expressions for LC-GFRP confinement, especially for non-U-shaped configurations.
Real Estate: Discovering the Developments in the Real Estate Sector Using the Current Research Challenges
Authors: De Paola Pierfrancesco
Published: October 2023

“Agenda 2030” is a wide-reaching plan established by the United Nations, in which 17 Sustainable Development Goals (SDGs) with 232 related indicators highlight the most important economic, social, environmental and governance challenges of our time [...]
Different Routes the Same Destination: “Oneness with Dao through Skill” in the Zhuangzi
Authors: Gai Fei
Published: October 2023

In “The Great and Venerable Teacher”, the Woman Crookback points out the path from words and language to behavior and practice, to enlightenment, and lastly, to obtaining the Dao, which is congruent with the “oneness with Dao through skill” route implicitly described in the Zhuangzi. The essential difference between “Zhuangzi’s skill”, which is capable of reaching the realm of Dao, and ordinary skills and arts is not found in the kind or level of abilities, nor in the tools required to do the skills, but rather in the self-knowledge of the “skill”. In order to clarify the natural patterns of things and one’s spiritual nature, as well as to reach the realm of “losing and again losing” and to remove all influences on the mind, one can use “Zhuangzi’s skill”, which can help the practitioner focus on one thing. Ultimately, the spiritual nature and the natural patterns will be in harmony with one another, matching up “Heaven” with “Heaven”, and becoming one with Dao.
Microinsurance and Economic Growth in Africa
Authors: Karagyozova Tsvetanka
Published: October 2023

The reach and scope of microinsurance have expanded considerably over the last couple of decades. The literature on microinsurance focuses predominantly on its microeconomic impact. In contrast, I examine the contemporaneous and intertemporal effect of microinsurance on economic development using rich census data of microinsurance coverage in African economies. Estimates suggest that microinsurance affects economic growth both on impact and over time, with the magnitude of the intertemporal effect exceeding that of the contemporaneous effect. Evidence also suggests nonlinearities in the microinsurance–growth nexus. The marginal effect of microinsurance is a negative function of the starting level of development. For low-income countries, microinsurance has a robust positive effect on economic growth, both in terms of impact and over time. However, microinsurance may fail to leave a lasting trace on the aggregate economy in “richer” developing countries.
Improved Drought Characteristics in the Pearl River Basin Based on Reconstructed GRACE Solution with Enhanced Temporal Resolution
Authors: Wang Linju , Zhang Menglin , Yin Wenjie , Li Yi , Hu Litang , Fan Linlin
Published: October 2023

As global warming intensifies, the damage caused by drought cannot be disregarded. Traditional drought monitoring is often carried out with monthly resolution, which fails to monitor the sub-monthly climatic event. The GRACE-based drought severity index (DSI) is a drought index based on terrestrial water storage anomalies (TWSA) observed by the gravity recovery and climate experiment (GRACE) satellite. DSI has the ability to monitor drought effectively, and it is in good consistency with other drought monitoring methods. However, the temporal resolution of DSI is limited by that of GRACE observations, so it is necessary to obtain TWSA with a higher temporal resolution to calculate DSI. We use a statistical method to reconstruct the TWSA, which adopts precipitation and temperature to obtain TWSA on a daily resolution. This statistical method needs to be combined with the time series decomposition method, and then the parameters are simulated by the Markov chain Monte Carlo (MCMC) procedure. In this study, we use this TWSA reconstruction method to obtain high-quality TWSA at daily time resolution. The correlation coefficient between CSR–TWSA and the reconstructed TWSA is 0.97, the Nash–Sutcliffe efficiency is 0.93, and the root mean square error is 16.57. The quality of the reconstructed daily TWSA is evaluated, and the DSI on a daily resolution is calculated to analyze the drought phenomenon in the Pearl River basin (PRB). The results show that the TWSA reconstructed by this method has high consistency with other daily publicly available TWSA products and TWSA provided by the Center for Space Research (CSR), which proves the feasibility of this method. The correlation between DSI based on reconstructed daily TWSA, SPI, and SPEI is greater than 0.65, which is feasible for drought monitoring. From 2003 to 2021, the DSI recorded six drought events in the PRB, and the recorded drought is more consistent with SPI-6 and SPEI-6. There was a drought event from 27 May 2011 to 12 October 2011, and this drought event had the lowest DSI minimum (minimum DSI = −1.76) recorded among the six drought events. The drought monitored by the DSI is in line with government announcements. This study provides a method to analyze drought events at a higher temporal resolution, and this method is also applicable in other areas.
LOS Deformation Correction Method for DInSAR in Mining Areas by Fusing Ground Data without Control Points
Authors: Li Jingyu , Yan Yueguan , Cai Jinchi
Published: October 2023

The traditional leveling, total station, and global navigation satellite system (GNSS) and the new differential interferometric synthetic aperture radar (DInSAR) and terrestrial laser scanning (TLS) systems have their own advantages and limitations in the deformation monitoring of mining areas. It is difficult to obtain accurate deformation information only using single-source measurement data. In this study, we propose an LOS deformation correction method for DInSAR in mining areas by fusing ground data without control points. Based on free space data, small deformations at the edges of mining influence areas accurately obtained using DInSAR. By combining leveling/GNSS and TLS methods, it was possible to obtain large deformations in central areas without the need for control points located outside the mining influence range. For overcoming the non-uniform coordinates of the “space–ground” data and the limited overlap of the effective measurement ranges, the subsidence prediction model was employed to assist in its fusion. In addition, in LOS deformation correction, we retained the non-full cycle phase of DInSAR and replaced the full cycle phase with the one from the data fusion. Engineering experiments have shown that the correction results preserve the differences in the LOS deformations at the edge areas of the mine influence range, and they recover the lost LOS deformations at the center areas. Using the difference in the LOS deformation before and after correction as the verification indicator, the maximum absolute value of the errors after correction was 143 mm, which was approximately 6.4% of the maximum LOS deformation. In addition, there were still two errors that were large (−112 mm and −89 mm, respectively), and the absolute values of errors were not more than 75 mm. For all errors, the mean absolute value was 36 mm. Compared with 399 mm before correction, the error was reduced by 91%. This study provides technical support and theoretical reference for deformation monitoring and control in mining areas.
Analysis of Ionospheric Anomalies before the Tonga Volcanic Eruption on 15 January 2022
Authors: Feng Jiandi , Yuan Yunbin , Zhang Ting , Zhang Zhihao , Meng Di
Published: October 2023

In this paper, GNSS stations’ observational data, global ionospheric maps (GIM) and the electron density of FORMOSAT-7/COSMIC-2 occultation are used to study ionospheric anomalies before the submarine volcanic eruption of Hunga Tonga–Hunga Ha’apai on 15 January 2022. (i) We detect the negative total electron content (TEC) anomalies by three GNSS stations on 5 January before the volcanic eruption after excluding the influence of solar and geomagnetic disturbances and lower atmospheric forcing. The GIMs also detect the negative anomaly in the global ionospheric TEC only near the epicenter of the eruption on 5 January, with a maximum outlier exceeding 6 TECU. (ii) From 1 to 3 January (local time), the equatorial ionization anomaly (EIA) peak shifts significantly towards the Antarctic from afternoon to night. The equatorial ionization anomaly double peak decreases from 4 January, and the EIA double peak disappears and merges into a single peak on 7 January. Meanwhile, the diurnal maxima of TEC at TONG station decrease by nearly 10 TECU and only one diurnal maximum occurred on 4 January (i.e., 5 January of UT), but the significant ionospheric diurnal double-maxima (DDM) are observed on other dates. (iii) We find a maximum value exceeding NmF2 at an altitude of 100~130 km above the volcanic eruption on 5 January (i.e., a sporadic E layer), with an electron density of 7.5 × 105 el/cm3.
Drone Photogrammetry for Accurate and Efficient Rock Joint Roughness Assessment on Steep and Inaccessible Slopes
Authors: Song Jiamin , Du Shigui , Yong Rui , Wang Changshuo , An Pengju
Published: October 2023

The roughness of rock joints exerts a substantial influence on the mechanical behavior of rock masses. In order to identify potential failure mechanisms and to design effective protection measures, the accurate measurement of joint roughness is essential. Traditional methods, such as contact profilometry, laser scanning, and close-range photogrammetry, encounter difficulties when assessing steep and inaccessible slopes, thus hindering the safety and precision of data collection. This study aims to assess the feasibility of utilizing drone photogrammetry to quantify the roughness of rock joints on steep and inaccessible slopes. Field experiments were conducted, and the results were compared to those of 3D laser scanning in order to validate the approach’s procedural details, applicability, and measurement accuracy. Under a 3 m image capture distance using drone photogrammetry, the root mean square error of the multiscale model-to-model cloud comparison (M3C2) distance and the average roughness measurement error were less than 0.5 mm and 10%, respectively. The results demonstrate the feasibility and potential of drone photogrammetry for joint roughness measurement challenges, providing a useful tool for practitioners and researchers pursuing innovative solutions for assessing rock joint roughness on precipitous and hazardous slopes.
Novel Compact Polarized Martian Wind Imaging Interferometer
Authors: Zhang Chunmin , Wang Yanqiang , Zhang Biyun , Yan Tingyu , Chen Zeyu , Chen Zhengyi
Published: October 2023

The Mars Atmospheric Wind Imaging Interferometer offers several advantages, notably its high throughput, enabling the acquisition of precise and high vertical resolution data on the temperature and wind fields in the Martian atmosphere. Considering the current absence of such an Interferometer, this paper introduces a novel Mars wind field imaging interferometer. In analyzing the photochemical model of O2 (a1Δg) 1.27 μm molecular airglow radiation in the Martian atmosphere and considering the impact of instrument signal-to-noise ratio (SNR), we have chosen an optical path difference (OPD) of 8.6 cm for the interferometer. The all-solid-state polarized wind imaging interferometer is miniaturized by incorporating two arm glasses as the compensation medium in its construction, achieving the effects of field-widening and temperature compensation. Additionally, an F-P Etalon is designed to selectively filter the desired three spectral lines of O2 dayglow, and its effect is evaluated through simulations. The accuracy of the proposed compact Mars polarized wind imaging interferometer for detecting Mars’ wind field and temperature field has been validated through rigorous theoretical derivation and comprehensive computer simulations. The interferometer boasts several advantages, including its compact and small size, static stability, minimal stray light, and absence of moving parts. It establishes the theoretical, technological, and instrumental engineering foundations for future simultaneous static measurement of Martian global atmospheric wind fields, temperature fields, and ozone concentrations from spacecraft, thereby significantly contributing to the dataset for investigating Martian atmospheric dynamics.