bluuebunny/crossref_metadata_2025 huggingface dataset:
Получение и свойства лизоцимсодержащих капель для слезозаменительной терапии
Authors: Романовская Ирина Игоревна , Декина Светлана Сергеевна , Сотникова Е. П. , Абрамова А. Б.
Published: September 2019

Показано, что включение лизоцима в растворы полимеров приводит к стабилизации фермента, обеспечивая длительное хранение в условиях низких температур (0 – 4 °C) в течение 12 мес с 96 % сохранением гидролитической активности. Изменения рН и термопрофилей активности включенного в растворы полимеров фермента способствуют активизации его действия в физиологических условиях и при ацидозе, сопровождающем появление воспалительных процессов различного генеза, а также при развитии синдрома сухого глаза. Исследование биохимических и физико-химических характеристик лизоцимсодержащего раствора показало, что разработанные глазные капли соответствуют требованиям, предъявляемым к таковым (плотность, вязкость, осмоляльность и показатель преломления, стерильность). Изучение офтальмобезвредности показало, что раствор не обладает аллергизирующим действием.
Современные регуляторные требования FDA к валидации биоаналитических методик в сравнении с требованиями ЕАЭС
Authors: Уварова Наталия Евгеньевна , Еременко Наталья Николаевна , Раменская Галина Владиславовна , Горячев Дмитрий Владимирович , Смирнов Валерий Валерьевич
Published: September 2019

Рассмотрены требования FDA к валидации биоаналитических методик, опубликованные в новом руководстве 2018 г., необходимые для подтверждения их надежности для определения концентрации анализируемого вещества. Кратко описана история регулирования валидации биоаналитических методик. Представлен обзор ключевых изменений и дополнений руководства FDA по валидации биоаналитических методик, которые включают в себя объединение требований к валидации хроматографических методик и методик связывания лиганда, указание на валидацию биомаркеров, выделение раздела, посвященного новым технологиям (например, методу сухой капли крови), введение концепции соответствия поставленным целям. Проведено сравнение требований к валидационным параметрам хроматографических методик руководства FDA и требований ЕАЭС. Несмотря на некоторые отличия, как в количестве параметров, так и в критериях их приемлемости, требования нового руководства FDA в целом согласуются с документом ЕАЭС.
Сравнительная оценка подходов определения примеси N-нитрозодиметиламина в фармацевтической субстанции валсартан методом газовой хроматографии с использованием масс-спектрометрического детектирования
Authors: Хорольский Михаил Дмитриевич , Ананьина О. В. , Чапленко А. А. , Недков И. В. , Масленникова Н. В. , Раменская Г. В.
Published: September 2019

Проведена сравнительная оценка методик определения генотоксичной примеси н-нитрозодиметиламина (НДМА) в фармацевтической субстанции валсартана методом ГХ c масс-спектрометрическим детектированием в режимах SIM и MRM с использованием прямого ввода и анализа паровой фазы. Сравнение методик показало незначительные различия в полученных показателях LOQ и LD. По итогу проведенных испытаний был сделан вывод о целесообразности использования метода, отвечающего возможностям и оснащению лаборатории.
Сравнительный анализ методик количественного определения дабигатрана в плазме крови пациентов, перенесших эндопротезирование коленного сустава
Authors: Козлов Алексей Владимирович , Смирнов Валерий Валерьевич , Сычев Дмитрий Алексеевич , Бочков Павел Олегович , Чистяков Виктор Владимирович , Степанова Елена Сергеевна , Макаренкова Любовь Михайловна
Published: September 2019

Для сравнительного анализа содержания дабигатрана в крови были взяты 2 разные методики из литературы для сопоставления результатов экспериментов по эффективности и точности. Исследование проведено на 30 пациентах, которые перенесли операцию на коленном суставе. Плазму крови отбирали у больных, которые проходят антикоагулянтную терапию и принимали препарат в дозе 220 мг. Остаточные и пиковые концентрации дабигатрана определяли методом ВЭЖХ-МС и ВЭЖХ-МС/МС.
Роль лекарственных взаимодействий в эффективности и безопасности кларитромицина при эрадикации Helicobacter pylori
Authors: Сереброва Светлана Юрьевна , Карева Елена Николаевна , Еременко Наталия Николаевна , Прокофьев Алексей Борисович , Кургузова Дарья Олеговна , Дроздов Владимир Николаевич , Лазарева Наталия Борисовна , Комиссаренко Ирина Арсеньевна , Стародубцев Алексей Константинович
Published: September 2019

В обзорной статье описаны современные риски резистентности, нежелательных лекарственных реакций и лекарственных взаимодействий кларитромицина при его применении в качестве компонента терапевтических схем эрадикации H. pylori. Кислотонеустойчивость кларитромицина в кислой среде определяет зависимость фармакологических свойств препарата от эффективности ингибиторов протонной помпы, что может быть одной из причин резистентности возбудителя к макролиду. Потенциал лекарственных взаимодействий кларитромицина связан c его способностью метаболизироваться с помощью CYP3A4 и мощно ингибировать этот фермент.
Entre holofotes e fracassos
Authors: Araújo Letícia de Sousa
Published: September 2019

Este artigo aborda o Programa Ronda do Quarteirão, segmento da polícia militar concebido e implementado em 2007 no Ceará e apresentado pelo governo estadual como uma proposta de polícia comunitária, a “Polícia da boa vizinhança”. O marketing político e estético por trás das propagandas enfatizava as possíveis mudanças que a sofisticada infraestrutura de trabalho do programa traria. A partir de 2008, no entanto, alguns episódios envolvendo ações policiais e comportamentos considerados desviantes por parte dos agentes de segurança que atuavam no Programa Ronda do Quarteirão suscitaram discussões sobre a viabilidade desta “nova polícia”. Percebeu-se, assim, que para além de uma proposta diferencial de polícia para o estado, de caráter preventivo e de proximidade, a recorrência a práticas de caráter repressivo por parte de seus agentes continuou a ser o modus operandi da segurança pública em seu conjunto.
A Unidade Integrada Pro Paz (UIPP) como novo paradigma da segurança pública no estado do Pará
Authors: Santana Alexandro Napoleão , Guimarães Jarsen Luis Castro
Published: September 2019

Este artigo discute o modelo de segurança pública adotado pelo estado do Pará desde 2011 e seu potencial para a não judicialização desnecessária de conflitos. Por meio de uma pesquisa bibliográfica e documental, além da aplicação de entrevistas semiestruturadas, foram analisados os aspectos relacionados à gestão pública estratégica do estado ao longo de um processo histórico de integração entre instituições públicas policiais e a Fundação Pro Paz, bem como a utilização da mediação extrajudicial de conflitos, que representa uma alternativa aos mecanismos repressivos. Neste contexto, foram contabilizadas as demandas e os resultados alcançados por um Núcleo de Mediação de Conflitos (NUMEC) instalado em uma Unidade Integrada Pro Paz (UIPP), na cidade de Santarém. Entre todas as demandas adequadamente registradas, mais da metade foi resolvida com sucesso. Portanto, mostrou-se relevante promover a investigação dessa política pública estadual, que tem por objetivo o estabelecimento de um novo paradigma de prevenção e enfrentamento da violência por meio da mediação e da aproximação estrategicamente planejada entre diversos órgãos públicos e a sociedade em um inovador padrão de unidade policial.
THE INVESTIGATION OF NANOMATERIALS IN TERM OF HUMAN HEALTH
Authors: KAYA Lezgin , KARA Memduh , SAYINCI Bahadır
Published: September 2019

Nanotechnology is one of today's most popular research areas. The reason for this is that, thanks to this technology, production can be much better and much smaller. Investments in this technology increase each year and it is predicted that the increase will continue. The fact that more nanomaterials are in our lives has become a necessity for further research into this technology. Many studies have been done on nanomaterials for a long time, but most of them are those that highlight the positive aspects of nanomaterials on humans. Until a few years ago, studies on the negative effects of nanomaterials on living things, especially humans, are insufficient. In recent years, increasing use of nanomaterials necessitated the examination of the effect on human health. As a result of research, some nanomaterials have been determined to have negative effects on human health. These materials are especially risky for workers during production. People and institutions working with nanomaterials need to take some security measures. These measures should be determined according to the properties of nanomaterials. Taking the necessary precautions reduces the possibility of exposure. The negative effects of nanomaterials on human health are still being investigated. However, thanks to its superior features, its popularity is rapidly increasing and it is expected to continue to increase.
INVESTIGATION OF THE MOMENT–CURVATURE RELATIONSHIP FOR REINFORCED CONCRETE SQUARE COLUMNS
Authors: FOROUGHİ Saeid , YÜKSEL Süleyman Bahadır
Published: September 2019

In this study; the effect of the material model, axial load, longitudinal reinforcement ratio, transverse reinforcement ratio and transverse reinforcement spacing on the behavior of reinforced concrete cross-sections were investigated. Squared cross-section column models have been designed. The effect of axial load, transverse reinforcement diameter and transverse reinforcement spacing on the behavior of reinforced concrete column models have been analytically investigated. The behavior of the columns was evaluated from the moment-curvature relation by taking the nonlinear behavior of the materials into account. The moment-curvature relationships for different axial load level, transverse reinforcement diameter and transverse reinforcement spacing of the reinforced concrete column cross-sections were obtained considering Mander confined model. Moment-curvature relationships were obtained by SAP2000 Software which takes the nonlinear behavior of materials into consideration. The examined effects of the parameters on the column behavior were evaluated in terms of ductility and the strength of the cross-section. In the designed cross-sections, the effect of transverse reinforcement diameter and transverse reinforcement variation on the confined concrete strength and the moment-curvature relationship was calculated and compared for constant longitudinal reinforcement ratio. The examined behavioral effects of the parameters were evaluated by comparing the curvature ductility and the cross-section strength. It has been found that transverse reinforcement diameters and transverse reinforcement spacing are effective parameters on the ductility capacities of the column sections. Axial load is a very important parameter affecting the ductility of the section. It has been observed that the cross-sectional ductility of the column sections increases with the decrease in axial load.
UTILIZING A GEOMECHANICAL CLASSIFICATION TO PRELIMINARY ANALYSIS OF ROCK SLOPE STABILITY ALONG ROADWAY D340- 41.42, SOUTHWEST OF TURKEY: A CASE STUDY
Authors: MOHAMED Ahmed , BAYRAM Ali Ferat
Published: September 2019

Road construction is mostly passed through mountainous regions or hilly terrains in Turkey like in all world. In hence, roadway construction and widening are being constructed through blasting and excavation, leading to rock slope instabilities and failures then poses threats to life and property. The reasons for failure sometime after construction are likely due to the deterioration of rock masses in cut slopes. However, slope instability and failures mainly occur due to adverse slope geomorphological complexities, joint discontinuities, weathering, man-made activities, unloading; and several induced factors such as seasonal heavy rainfall events, snow coverage, etc. The objectives of this paper are therefore to identify the most significant parameters influencing the behavior of cut slope rock masses with employing SMR ,and to perform a preliminary slope instability assessment along roadway D340- 41.42, southwest of Turkey, where slopes located in a region of Taurus’s rugged terrains with known complex geometry, then propose a suitable control measures to mitigate potential failures of rock slope stability. In this study, 19 rock cuts are selected based on the observed failure mechanisms, slope geometry and materials. A systematic site investigation incorporating relevant engineering geological and geotechnical parameters were carried out in detail. Based on slope instability observations and SMR results rating, concluded that these slopes were widely controlled by discontinuities (structurally controlled failures). As well, SMR classification scheme was successfully used for failure classification in Taurus’s terrains. Finally, slope flattening with various angles method, wire mesh, toe support by detached rock blocks and drainage ditches redesign are proposed as a remedial measurement to protect road slope stability from failure.
OPTIMAL DESIGN OF POWER TRANSFORMER TANK USING ANT/FIREFLY HYBRID HEURISTIC ALGORITHM
Authors: ZİLE Mehmet
Published: September 2019

Power transformers are one of the most important and expensive components of power transmission lines. Reducing costs in the manufacture of power transformers has always been the subject of science. In this study, an ant/firefly hybrid heuristic algorithm has been developed to optimize the materials used in power transformer tanks and therefore to reduce tank costs. Based on this algorithm, an interface program has been created in Visual Studio Program. Using this power transformer tank design computer program, the materials used in the tanks have been optimized. As a result of the optimization, the materials used in the transformer tank, which is designed as a result, are saved between 5% and 15%. By this study, it has become possible to reduce the manufacturing costs of power transformers.
FABRICATION OF TiO2 BASED COMPOSITE MATERIALS BY HYDROTHERMAL METHOD
Authors: CANBAY Canan Aksu , ÖZBEY Furkan
Published: September 2019

Composite nanoparticles (nano powders) are nano-sized and can be synthesized with a wide range of organic, inorganic materials and production techniques. Titanium dioxide is one of the most commonly used materials in the production of composite materials. The reason why titanium dioxide is more preferred is that it has a minimum of any reactive step, it does not interfere with the human body and is an organic material that does not contain by-products. The photocatalytic properties of titanium dioxide can be improved by various methods. TiO2 is the most widely used photocatalyst in air purification. In this study, titanium dioxide based composite material was fabricated by hydrothermal method. The electrical, optical and structural properties of the material were investigated with the contribution of three different compositions of cadmium oxide (CdO) for produced in the experiments. For this purpose, SEM, U-V (Vis), I-V and FTIR techniques were used for the characterization and obtained results evaluated.
「復元論」と「分化発生論」について ― 宇野弘蔵と山口重克の方法論をめぐって―
Authors: Horiuchi Daiki
Published: September 2019

【構成】序言第１節　 宇野弘蔵の「復元論」について１　 宇野弘蔵のマルクス上向法批判２　 「歴史＝論理説」批判と「永久循環」３　 弁証法的展開方法と「復元力」４　 宇野弘蔵における弁証法理解５　 小括第2節　 山口重克の「分化発生論」について１　 山口重克の宇野方法論批判２　 山口重克における当事者行動論と分化発生論３　 分化論的観点、発生論的観点、競争論的観点、当事者行動論的観点、機構論的観点４　 当事者行動論的観点における方法論的「個体」主義の多義性５　 機構論的観点における静態論と動態論６　 分化発生論から発生進化論へ補説 小幡道昭の開口部論について７　 小括結語
Note to Prove the Quranic Correctness XI
Authors: Horiuchi Daiki , ibn Afaq Uthman
Published: September 2019

Maybe a beautiful equality about Riemann's zeta function has some relations with Tahara's I function, maybe not.
Restriction of non-coding elements in the thymus by Aire
Authors: Mamoor Shahan
Published: September 2019

Aire is a unique transcriptional molecule that functions in immunological tolerance by promoting promiscuous expression of tissue-restricted genes. The expression of these otherwise tissue-restricted genes in the medullary epithelial cells of the thymus (mTECs) allows the presentation of self antigens to “teach” cells of the immune system what it means to be “self”. To understand the role of Aire in shaping the mTEC transcriptome, I performed global differential gene expression analysis of wild-type mTECs and mTECs deficient in Aire. I identified nineteen non-coding molecules whose expression were significantly modulated by the absence of Aire. These included pseudogenes, antisense RNA, small nucleolar and small nuclear RNA, and long non-coding RNA. This finding reveals that Aire controls the expression of both coding and non-coding genes, and further suggests that non-coding RNA might play a role in Aire’s instruction of immunological tolerance.
Note to Prove the Quranic Correctness XII
Authors: Horiuchi Daiki , ibn Afaq Uthman
Published: September 2019

Maybe a beautiful equality about the results of Riemann's zeta function ζ(-2n) has some relations with Tahara's I function, maybe not.
研究不正から読み解くもの—ゴムひもで長さを測る世界からイノベーションへ
Authors: Horiuchi Daiki
Published: September 2019

研究不正は「ゴムひもで長さを測る世界」すなわち検証の難しい分野で起こりやすい。不正研究者個人の資質に加えて、激烈な科学界の競争環境が背景にある。❷不正は不正、厳正に淡々と処置すべきだ。ただし、メディアスクラムで周辺を巻き込んでの大騒ぎは異様である。マスコミの加熱は劇場型で面白いが、本来追及すべき他の重大不正から目をそらせる。❸研究論文は個人研究者の産物であり、組織が有償販売することを前提とした製品ではない。無償で公開され世界中の研究者が無償で自由に使える点で、組織の「製造物責任」にはなじまない。❹予防、早期発見、合理的な対応のシンプルなシステム化が重要である。ただし不正をゼロにすることには限界があり、まれな個人の研究不正のために過剰に科学を管理することはイノベーションを阻害する恐れがある。
Note to Prove the Quranic Correctness X
Authors: Horiuchi Daiki , ibn Afaq Uthman
Published: September 2019

Maybe a beautiful equality about Riemann's zeta function hassome relations with Tahara's I function, maybe not.
境界を越えた「モノのもつ意味」の変化について：オリエンタリズム的思考に対する気づき
Authors: Tahara Hiroki
Published: September 2019

本稿は、京都大学総合人間学部の文化環境学系入門講義の一環として04/12に行われた「オセアニアにおける環境と人間」で課された課題『授業でとりあげた事例を参考にしながら、境界を越えた「モノのもつ意味」の変化について考察しなさい。字数は、400～600字程度。参照文献がある場合には、必ず明記すること。締切は、2021年4月19日午前8時とする。』に対する提出レポートである。時間がめちゃくちゃやばい。本来であれば明確に主張すべき命題を提示するべきであるのだろうが、自らの知見不足のせいでまったくと言ってまとまった成果と呼べるような産物は出なかったので、徒然草方式で書くことにした。
月語掌篇文芸試論=Getugo Syôhen Bungei Siron (Attempts of Uzbek Very Short Short Stories)　定価759,800円
Authors: Tahara Hiroki
Published: September 2019

この度、自らの文芸作品として『月語掌篇文芸試論』を刊行させていただくことになった。月語とはウズベク語の略であり、掌篇とは短篇よりも短いほどの長さの小説のことである。つまりこれはウズベク語で書かれたごくごく短い文芸の作品集である。自分は完全に理系の脳みそをしているが、様々な要因より芸術表現の可能性、特に文芸について従来より大きな興味を持っていた。また、これとは別に、これまた様々な要因よりウズベク文化に大きな魅力を感じてきた。2月半ばに合格発表があり（ありがたいことに世界有数の大学に特色で拾っていただけた）、研究や恋愛を含め自分のしたいことを自由にできる時間ができたため、このような作品を作ってやろうじゃないかという意気込みが生まれ、結果このように作品を刊行することができた。勿論、試論とあるようにこれらは試し書きであり、1か月弱で書き上げたものであるため文法内容ともにかなりおかしな部分があると思うが、本を一冊作れるほどの情熱が自分にあったという事実に、自己満足的に感動を覚えている。刊行にあたって数人の仲間たち（関西外語文芸研究同志とでも名付けよう）の協力を得ることができた。彼らには強く感謝している。彼らとは現在、ウズベク語並びに他の外国言語を用いた文芸の雑誌を企画している最中である。大学に入ったのち、それらを実行に移せることが待ち遠しい限りである。
時間に関してオズマ問題は存在しないか
Authors: ibn Afaq Uthman
Published: September 2019

ようこそトルコヘ! アンタルヤとその周辺地域」は、美しい街アンタルヤ、トルコの観光中心地ブルドゥル、美しい湖とカーペットや絨毯の魅力で知られるメルスィン、自然の美しさと歴史的・文化的な豊かさに囲まれたビーチのある太陽ふりそそぐ街アダナ、そして自然、文化、グルメなどに関する情報を盛り込んだパンフレットです。本誌『アンタルヤとその周辺地域』をぜひお楽しみください。トルコでお会いしましょう！
Note to Prove the Quranic Correctness XIV
Authors: Horiuchi Daiki , ibn Afaq Uthman
Published: September 2019

Maybe a beautiful equality about Riemann's zeta function and Mobius' mu function has some relations with Tahara's I function, maybe not.
米国銀行における中小企業金融の実態
Authors: Horiuchi Daiki
Published: September 2019

従業員数 20 万人以上の超巨大銀行がある一方で, 地域密着型小銀行が多数を占めるなど, 米国には, 多彩な銀行群が存在する. そうした米国銀行の中小企業向け金融は, そもそも, どのような貸付商品で構成され, 実際にどのように運用されているのか.
Ethics of Information in the Digital Age
Authors: PALETTA FRANCISCO CARLOS , da Silva Armando Manuel Barreiros
Published: September 2019

This study aims to present partial results on the research project Tecnologia da Informação em Biblioteca Digital e Sistemas Abertos – Estudos de Usuário da Informação na Web de Dados (Information Technology in Digital Library and Open Systems – Studies on Users of Information on Data Web), conducted by the School of Communications and Arts from University of São Paulo in cooperation with the Faculty of Letters of the University of Porto. The study presents reflections on ethical dimensions that accompany the current digital era. It discusses the importance of understanding the demands of the information user in the Data Web, with a view to teach a course named Ethics of Information at undergraduate programs in ibrarianship, Archivology, Museology, and Information Science, which condenses these reflections and problems, Developing skills for an ethical action in the formation of the information professional in the network society.
Note to Prove the Quranic Correctness III
Authors: Horiuchi Daiki , ibn Afaq Uthman
Published: September 2019

Maybe a beautiful equality about Riemann's zeta function has some relations with Tahara's I function, maybe not.
Hanoi’s early 20th century: “On the second floor - Phố Phái”
Authors: Ho Toan Manh , Hoang Hanh Phuong , Vuong Thu-Trang
Published: September 2019

And not just look; one needs to know where to look as well. In this case: look upwards, on the second floor of the old townhouses, which has not been replaced by showcasing pavilions or modern glass doors. Some houses have been repainted, but the architecture – the form of the story, the shapes, and construction of the balconies, the decorating sculptures – still exudes a century-old familiarity. So it turns out that Phố Phái, though no longer intact, is still present here.
When culture and mathematics meet: A reflection on a study of Hanoi ancient houses
Authors: Anh Tran Ha
Published: September 2019

In the age of rapid urbanization and digitization, it is astounding that we can still find in Vietnam, especially around its capital city Hanoi, remnants of the thousand years of Chinese influence, a century of French colonialism, and over two decades of war against the Americans.
Note to Prove the Quranic Correctness VIII
Authors: Horiuchi Daiki , ibn Afaq Uthman
Published: September 2019

Maybe a beautiful equality about Riemann's zeta function has some relations with Tahara's I function, maybe not.
事例でわかる 職場のリスクアセスメント
Authors: Horiuchi Daiki
Published: September 2019

リスクアセスメントは、職場の潜在的な危険性又は有害性を見つけ出し、これを除去、低減するための手法です。労働安全衛生マネジメントシステムに関する指針では、「危険性又は有害性等の調査及びその結果に基づき講ずる措置」の実施、いわゆるリスクアセスメント等の実施が明記されていますが、平成18年4月1日以降、その実施が労働安全衛生法第28条の2により努力義務化されました。また、その具体的な進め方については、同条第2項に基づき、「危険性又は有害性等の調査等に関する指針」が示されています。
Note to Prove the Quranic Correctness IX
Authors: Horiuchi Daiki , ibn Afaq Uthman
Published: September 2019

Maybe a beautiful equality about Riemann's zeta function has some relations with Tahara's I function, maybe not.
Note to Prove the Quranic Correctness XVII
Authors: Horiuchi Daiki , ibn Afaq Uthman
Published: September 2019

Maybe a beautiful equality about Riemann's zeta function and Euler's phi function has some relations with Tahara's I function, maybe not.
｢附中タイム｣の取り組み
Authors: Horiuchi Daiki
Published: September 2019

Maybe a beautiful equality(∫(0~∞)(sin(x)/x)dx)^2=Σ(k=0~∞)((2k)!/((2^(2k))((k!)^2)(2k+1)))=Π(k=1~∞)(4(k^2)/((4(k)^2)-1))=(π/2) has somerelations with Tahara's I function, maybe not.
Note to Prove the Quranic Correctness XIII
Authors: Horiuchi Daiki , ibn Afaq Uthman
Published: September 2019

Maybe a beautiful equality about Riemann's zeta function has some relations with Tahara's I function, maybe not.
Kepemimpinan dan Manajemen Pendidikan Kepala Sekolah Teladan Sumiati
Authors: Badriyah  , Mubarak Muhammad Zaidan
Published: September 2019

Pendidikan merupakan syarat mutlak untuk dapat mencapai suatu kemajuan, dengan pendidikan kita dapat mengimbangi roda perkembangan kemajuan dunia yang akan meninggalkan orang-orang yang tidak berkompeten untuk mengikutinya. Pendidikan berkaitan erat dengan icon-icon pelaku, pendukung dan proses dari pendidikan tersebut. Bila mutu pendidikan hendak diperbaiki, mutu sumber daya manusia (SDM) pendidikan harus diperbaiki terlebih dahulu. Singkatnya, mutu pendidikan amat bergantung pada SDM pendidikan dan proses dari pendidikan tersebut. Mutu SDM pendidikan amat besar pengaruhnya terhadap mutu dari pendidikan itu sendiri.Berdasarkan pemikiran di atas, pendidikan sebagai ujung tombak “penghasil SDM” mengemban tugas yang penting dan sangat strategis. Sehubungan dengan itu, keberadaan seorang pemimpin pendidikan adalah sebagai orang yang memegang peranan kunci (key position) dalam rangka mencapai tujuan di atas. Keberadaan seorang pemimpin dalam dunia pendidikan sangat diperlukan walaupun seringkali sulit untuk memilih dan mendapatkannya.
Strategi dan Analisis MSDM
Authors: Wati Enny
Published: September 2019

Proses perencanaanan manajerial dasar melibatkan penetapan tujuan, membuat ramalan perencanaan dasar, meninjau rangkaian tindakan alternative, mengevaluasi opsi mana yang terbaik, dan memilih serta melaksanakan rencana (Dessler; 2016) Rencana strategis adalah rencana keseluruhan perusahaan mengenai bagaimana mereka akan menyesuaikan kekuatan dan kelemahan internal dengan kesempatan dan ancaman eksternal yang bertujuan untuk mempertahankan keunggulan kompetitif.
The Effects of Wastewater from Shrimp Farm in South Qeshm
Authors: Karimi Mehdi , Darabinia Farhad
Published: September 2019

Released effluents containing high levels of pathogenic and non-pathogenic microorganism enhanced coastal aquatic mortality. A shrimp farm is going to be constructed in the southern coast of Qeshm Island. The reviews represent that the initial design of inlet and outlet does not meet minimum requirements for coastal water quality parameters. In this study, we defined three options, one initial design and two newly proposed, in order to investigate the concentration of pollution in coastal area using numerical models. Two new breakwaters constructed in the area decreased coastal current significantly, therefore, the initial design failed to meet water quality standards and need to be modified. The third proposed scenario was selected as the best option for intake and outtake locations.
Human life histories as dynamic networks: using Network Analysis to conceptualize and analyze life history data
Authors: Međedović Janko Mileta
Published: September 2019

The examination of multiple life history indicators is essential to evolutionary sciences. However, the statistical analysis of life history parameters' covariation is not apparently clear, due to the statistical limitations of “classic” procedures like Factor Analysis and conceptual problems in interpreting covariation between life-history indicators as latent factors. Here we propose that Network Analysis represents a promising framework for the exploration of life history parameters. First, we briefly describe the basic metric of Network Analysis: nodes, edges, proximities, clustering, centrality indices and small-world estimations. Next, we show the implementation of Network Analysis using the empirical set of life history variables as an example (N=460). We showed that Network Analysis provided: 1) optimal level of information - higher than factor analysis and lower than correlation analysis; 2) findings which are in accordance with the existing life history data; 3) the estimation of age at first birth as a central node in the network; 4) dynamic view of life history events which can represent a solid basis for causal life history models. In sum, Network Analysis shows high potential both for conceptualizing life history pathways as dynamic networks and for statistical analysis of the covariation between the life history indicators.
The structure of psychopathology and association with poor sleep, self-harm, suicidality, risky sexual behaviour, and low self-esteem in a population sample of adolescents
Authors: Sunderland Matthew , Forbes Miriam K. , Mewton Louise , Baillie Andrew James , Carragher Natacha , Lynch Samantha J , Batterham Philip , Calear Alison , Chapman Cath , Newton Nicola , Teesson Maree , Slade Tim
Published: September 2019

There is a growing body of evidence highlighting the presence of a single general dimension of psychopathology that can account for multiple associations across mental and substance use disorders. However, relatively little evidence has emerged regarding the validity and utility of this model with respect to a range of factors that have been previously implicated across multiple disorders. The current study utilised a cross-sectional population survey of adolescents (n=2003) to examine the extent that broad psychopathology factors account for specific associations between psychopathology and poor sleep, self-harm, suicidality, risky sexual behaviour, and low self-esteem. Confirmatory factor models, latent class models, and factor mixture models were estimated to identify the best structure of psychopathology. Structural equation models were then estimated to examine the broad and specific associations between each psychopathology indicator and the validity indicators. A confirmatory factor model with three lower order factors, representing internalizing, externalizing, and thought disorder, and a single higher order factor evidenced the best fit. The associations between manifest indicators of psychopathology and validity indicators were largely non-specific. However, significant direct effects were found between several important pairwise associations. These findings have implications for the identification of potential targets for intervention and/or tailoring of prevention programs.
Disentangling the Effects of Processing Speed on the Association between Age Differences and Fluid Intelligence
Authors: Schubert Anna-Lena , Hagemann Dirk , Löffler Christoph , Frischkorn Gidon T.
Published: September 2019

Several studies have demonstrated that individual differences in processing speed fully mediate the association between age and intelligence, whereas the association between processing speed and intelligence cannot be explained by age differences. Because measures of processing speed reflect a plethora of cognitive and motivational processes, it cannot be determined which specific processes give rise to this mediation effect. This makes it hard to decide whether these processes should be conceived of as a cause or an indicator of cognitive aging. In the present study, we addressed this question by using a neurocognitive psychometrics approach to decompose the association between age differences and fluid intelligence. Reanalyzing data from two previously published datasets containing 223 participants between 18 and 61 years, we investigated whether individual differences in diffusion model parameters and in ERP latencies associated with higher-order attentional processing explained the association between age differences and fluid intelligence. We demonstrate that individual differences in the speed of non-decisional processes such as encoding, response preparation, and response execution, and individual differences in latencies of ERP components associated with higher-order cognitive processes explained the negative association between age differences and fluid intelligence. Because both parameters jointly accounted for the association between age differences and fluid intelligence, age-related differences in both parameters may reflect age-related differences in anterior brain regions associated with response planning that are prone to be affected by age-related changes. Conversely, age differences did not account for the association between processing speed and fluid intelligence. Our results suggest that the relationship between age differences and fluid intelligence is multifactorially determined. Data and analysis code are available at https://osf.io/hy5fw/.
Finding the P3 in the P600: Decoding shared neural mechanisms of responses to syntactic violations and oddball targets
Authors: Sassenhagen Jona , Fiebach Christian
Published: September 2019

The P600 Event-Related Brain Potential, elicited by syntactic violations in sentences, is generally interpreted as indicating language-specific structural/combinatorial processing, with far-reaching implications for models of language. P600 effects are also often taken as evidence for language-like grammars in non-linguistic domains like music or arithmetic. An alternative account, however, interprets the P600 as a P3, a domain-general brain response to salience. Using time-generalized multivariate pattern analysis, we demonstrate that P3 EEG patterns, elicited in a visual Oddball experiment, account for the P600 effect elicited in a syntactic violation experiment: P3 pattern-trained MVPA can classify P600 trials just as well as P600-trained ones. A second study replicates and generalizes this finding, and demonstrates its specificity by comparing it to face- and semantic mismatch-associated EEG responses. These results indicate that P3 and P600 share neural patterns to a substantial degree, calling into question the interpretation of P600 as a language-specific brain response and instead strengthening its association with the P3. More generally, our data indicate that observing P600-like brain responses provides no direct evidence for the presence of language-like grammars, in language or elsewhere.
Working memory as persistent neural activity
Authors: Foster Joshua J. , Vogel Edward K. , Awh Ed
Published: September 2019

Working memory (WM) is an online memory system that allows us to hold information “in mind” in service of ongoing cognitive processing. Here, we emphasize that short-term retention of information typically involves an interplay between WM and long-term memory (LTM), especially when task demands or interruptions divert our focus from remembered items. We suggest that active neural representation may distinguish between “online” representations in WM and “offline” representations in LTM. This perspective is at odds with “activity-silent” models of WM, which hold that WM representations can be sustained without persistent neural activity. We suggest that activity-silent representations might be more productively conceptualized as offline representations in LTM because accessing these representations shows multiple signatures of retrieval from LTM. Moreover, active neural traces track WM load, predict individual differences in performance, and respect sharp item limits in WM storage. Thus, we argue that using neural activity as an operational definition of WM may provide strong traction for studying the dynamic collaboration between WM and LTM that is critical for intelligent behavior.
Lexical-semantic and executive deficits revealed by computational modelling: a drift diffusion model perspective
Authors: Todorova Lara , Neville David , Piai Vitória
Published: September 2019

Flexible language use requires coordinated functioning of two systems: conceptual representations and control. The interaction between two systems can be observed when people are asked to match a word to a picture. Participants are slower and less accurate for related word-picture pairs (word: banana, picture: apple) relative to unrelated pairs (word: banjo, picture: apple). The mechanism underlying interference however is still unclear. We analyzed word-picture verification (WPM) performance of patients with stroke-induced lesions to the left-temporal (N = 5) or left-frontal cortex (N = 5) and matched controls (N = 12) using the drift diffusion model (DDM). In DDM the process of making a decision is described as the stochastic accumulation of evidence towards a response. The parameters of the DDM model that characterize this process are decision threshold, drift rate, starting point and non-decision time. Each of them bears cognitive interpretability and we compared the estimated model parameters from controls and patients to investigate the mechanisms of WPM interference. WPM performance in controls was explained by the amount of information needed to make a decision (decision threshold): a higher threshold was associated with related word-picture pairs relative to unrelated ones. No difference was found in the quality of the evidence (drift rate). This suggests an executive rather than semantic mechanism underlying WPM interference. Both patients with temporal and frontal lesions exhibited both increased drift rate and decision threshold for unrelated pairs relative to related ones. Left-frontal and temporal damage affected the computations required by WPM similarly, resulting in systematic deficits across lexical-semantic memory and executive functions. These results support a diverse but interactive role of lexical-semantic memory and semantic control mechanisms.
Inactivated Peripheral Fusiform Face Area
Authors: Yousef Ahmad
Published: September 2019

We tried to entirely inactivate the peripheral fusiform face area, see description of the aforementioned brain area in reference 1. We were able to achieve great inactivation to the aforementioned area by using red background for the rabbit-duck rivalrous stimulus. We think that this inactivation had occurred for two reasons; first, because red color is very silent, and therefore greater request of oxygenated hemoglobin by V4 area. Second, the low contrast of the stimulus (black drawing on red background) constricts the pupil size, therefore, lesser light rays will reach to retinal peripheries, and its corresponding neurons in the FFA.
Utterance Chunking in Instant Messaging: A Resource for Interaction Management
Authors: Markman Kris M
Published: September 2019

Modern organizations have an array of communication tools available for interacting with both internal and external audiences. While email continues to dominate much workplace interaction, the use of instant messaging (IM) continues to grow (Garrett & Danziger, 2007), prompting scholars to look at how it is used in a variety of organizational contexts. In this chapter, I first give a background on the research into IM use in organizations. I will then look at IM as a form of conversation, and discuss why adopting a language-based approach to the study of IM is useful for communication professionals. I illustrate this discussion with an examination of one particular phenomenon, utterance chunking, in task-based IM interactions. Finally I will conclude by discussing the implications of this research for business discourse and make some suggestions for future research in this area.
Neuromuscular function and fatigability in people diagnosed with head and neck cancer before versus after treatment
Authors: Lavigne Colin , Lau Harold , Francis George , Culos-Reed S. Nicole , Millet Guillaume Y. , Twomey Rosemary
Published: September 2019

Purpose: Treatment for head and neck cancer is associated with multiple side-effects, including loss of body mass, impaired physical function, and reduced health-related quality of life. This study aimed to investigate the impact of treatment (radiation therapy ± concurrent chemotherapy) on (i) muscle strength, muscle cross-sectional area and patient-reported outcomes, and (ii) central and peripheral alterations during a whole-body exercise task.Methods: Ten people with head and neck cancer (4 female; 50±9 years) completed a lab visit before and after (56±30 days) completion of treatment. Participants performed a neuromuscular assessment (involving maximal isometric voluntary contractions in the knee extensors and electrical stimulation of the femoral nerve) before and during intermittent cycling to volitional exhaustion. Anthropometrics and patient-reported outcomes were also assessed.Results: From before to after treatment, maximal isometric muscle strength was reduced (P=0.002, d=0.73), as was potentiated twitch force (P<0.001, d=0.62), and muscle cross-sectional area (e.g. vastus lateralis: P=0.010, d=0.64). Exercise time was reduced (P = 0.008, d = 0.62) and peripheral processes contributed to a reduction in maximal force due to cycling. After treatment, the severity of self-reported fatigue increased (P=0.041, r=-0.65) and health-related quality of life decreased (P=0.012, r=-0.79).Conclusion: Neuromuscular function was impaired in patients with head and neck cancer after treatment. Whole-body exercise tolerance was reduced and resulted in predominantly peripheral, rather than central, disturbances to the neuromuscular system. Future research should evaluate strength training after treatment for head and neck cancer, with the overall aim of reducing fatigue and improving health-related quality of life.
Kondisi Alam pada Awal Waktu Ṣholāt Maktūbah di Daerah Tropis
Authors: Mughni Nur Tsalits Fahman , Setiawan Adib Rifqi
Published: September 2019

Pada dasarnya awal waktu ṣholāt maktūbah ditentukan oleh posisi Matahari di langit. Karena itu, waktu ṣholāt maktūbah bervariasi di berbagai lokasi di Bumi. Penelitian ini meneliti kondisi alam pada awal waktu ṣholāt maktūbah di daerah tropis berdasarkan perhitungan dan pengamatan.
Topik Matematika dalam Taqrīb
Authors: Mughni Nur Tsalits Fahman , Setiawan Adib Rifqi
Published: September 2019

Penelitian ini membahas tentang topik Matematika yang terdapat dalam Taqrīb, yang merupakan salah satu buku Fiqih.
Perbandingan Penafsiran antara Imām Jalāl al-Dīn al-Maḥallī dan Imām Jalāl al-Dīn al-Suyūṭī dalam Tafsīr al-Jalālayn
Authors: Mughni Nur Tsalits Fahman , Setiawan Adib Rifqi
Published: September 2019

Tafsīr al-Jalālayn adalah tafsir klasik al-Qur'ān, yang disusun kali pertama oleh Imam Jalāl al-Dīn al-Maḥallī pada tahun 1459 dan kemudian diselesaikan setelah wafatnya oleh muridnya Imām Jalāl al-Dīn al-Suyūṭī pada tahun 1505. Ia diakui sebagai salah satu tafsīr al-Qur'ān paling populer saat ini, karena gayanya yang sederhana dan keringkasannya, seiring hanya terdiri dari satu volume. Penelitian ini membahas perbandingan corak penafsiran antara Imām Jalāl al-Dīn al-Maḥallī dan Imām Jalāl al-Dīn al-Suyūṭī dalam Tafsīr al-Jalālayn.
Perbandingan Corak Penafsiran antara Imām Jalāl al-Dīn al-Maḥallī dan Imām Jalāl al-Dīn al-Suyūṭī dalam Tafsīr al-Jalālayn
Authors: Mughni Nur Tsalits Fahman , Setiawan Adib Rifqi
Published: September 2019

Penelitian ini membahas perbandingan corak penafsiran antara Imām Jalāl al-Dīn al-Maḥallī dan Imām Jalāl al-Dīn al-Suyūṭī dalam Tafsīr al-Jalālayn.
The Historical Trajectory of the Madrasah Banat Nahdlatul Ulama Kudus
Authors: Si'ayah Syarofis , Setiawan Adib Rifqi
Published: September 2019

This work examines the historical trajectory of the Madrasah Banat Nahdlatul Ulama Kudus by collecting informations based on retrospective interview and naturalistic observation. Madrasah Banat Nahdlatul Ulama Kudus, known mononymously as MANUBAKU, is one of the educational institutions in which of all students are female. The presence of MANUBAKU as an effort to realize the ideals of its founders who want to raise the degree of women through education to produce forces women educators who have an intellectual and akhlaqul karimah accordance with the teachings of Islam Ahlussunnah Waljama'ah. In history, MANUBAKU was established in 1940, a young man named Kiai Mas Da’in Amin Said (the little brother to 2 of 12 brothers Kiai Arwani Amin Sheikh KH) as a chairman assisted by Kiai Ahdlori Uthman (vice chairman), Noor Zainuri Rohmad (secretary), Noor Dahlan (treasurer) and Rodli Millah (member) who are members of the board initiated the establishment of kindergartens as the embryo of MANUBAKU. Twelve years later, in 1952 MI Banat NU kudus was born, that is followed by the establishment of MTs Banat NU Kudus in 1957. In January 1st, 1971, Madrasah Aliyah Banat NU Kudus was realized. After a long periods, MANUBAKU realized SMK NU Banat on 13 Juni 2007. Exactly two years later, MANUBAKU has started the Best Quality Class. This class opened by 31 students who all became students of PPYUR (Pondok Pesantren Yanaabi'ul Ulum Warrahmah). The student to special class were taken from the selection acceptance of new students that year.
Ḥisāb dan Ru’yat Waktu Ṣholāt Maktūbah di Daerah Tropis
Authors: Mughni Nur Tsalits Fahman , Setiawan Adib Rifqi
Published: September 2019

Penelitian ini mengamati panjang bayangan benda di Bumi dan pemandangan Langit pada awal waktu ṣholāt maktūbah di daerah tropis. Waktu pengamatan ditentukan menggunakan perhitungan astronomi, sementara kriteria panjang bayangan benda di Bumi dan pemandangan Langit didasarkan terhadap uraian awal waktu ṣholāt maktūbah dalam Taqrīb.
Perbandingan Matan al-Ājrūmiyyah Ibn Ājurrūm dan Naḍhom al-Khulāṣhoh al-Alfiyyah Ibn Mālik
Authors: Mughni Nur Tsalits Fahman , Setiawan Adib Rifqi
Published: September 2019

Penelitian ini membandingkan uraian Naḥwu dalam Matan al-Ājrūmiyyah karya Ibn Ājurrūm dan Naḍhom al-Khulāṣhoh al-Alfiyyah karya Ibn Mālik.
Perbedaan Uraian Naḥwu dalam Matan al-Ājrūmiyyah Ibn Ājurrūm dan Naḍhom al-Khulāṣhoh al-Alfiyyah Ibn Mālik
Authors: Mughni Nur Tsalits Fahman , Setiawan Adib Rifqi
Published: September 2019

Penelitian ini membahas perbedaan uraian Naḥwu dalam Matan al-Ājrūmiyyah karya Ibn Ājurrūm dan Naḍhom al-Khulāṣhoh al-Alfiyyah karya Ibn Mālik.
IMPLEMENTASI KEBIJAKAN EARMARKING TAX ATAS PEMUNGUTAN PAJAK KENDARAAN BERMOTOR DI KOTA BEKASI PROVINSI JAWA BARAT
Authors: Agustianto Jiwa Pribadi , Hidajat Krisna , Andarani Ayu Fitria
Published: September 2019

The phenomenon in the research is that there are still many congestion points due to the lack of road construction, lack of infrastructure related to road maintenance, and inadequate transportation modes. This study aims to analyze the Implementation of Earmarking Tax Policy on Vehicle Tax Collection in Bekasi City West Java Province along with the constraints and efforts in implementation. The research method used a qualitative approach with descriptive specificity. The result of the research is the implementation of the Earmarking Tax Policy on the Collection of Motor Vehicle Tax in Bekasi City, West Java Province for the compliance of the implementor in the matter of levying already in accordance with the regulation, but the allocation has not been maximal yet. Functional routine implementers are not yet maximal because there are still few technical issues and separation of funding post / account in the allocation, and no further regulations regarding technical and standard operating procedure (SOP) for earmarking tax funds can not be seen and controlled. The realization of the performance and the desired impact is also not optimal because there are still many congestion points and road structures that are still not good and adequate public transportation for the entire reach of the City of Bekasi.
FUTURISM IN METAPOETRY CONCEPT BY V. BRUSOV
Authors: STEIN KLARA
Published: September 2019

The paper deals with V. Brusov’s research on meta poetry. The author considers the influence of philosophy of Baruch Spinoza, Immanuel Kant, and Gottfried Leibniz’s theory of knowledge on meta poetry concept by V. Brusov. V. Brusov’s research on avant-garde art, pri-marily, on futurism, is also considered in the paper. The author con-cludes that V. Brusov is even-handed: he slams futurism, nevertheless, he does not impose his mindset and recognizes the resulting entitle-ment to its progress.
SCIENCE AND IMAGE OF A SCHOLAR IN WORKS BY V. BRUSOV
Authors: KARABEGOVA YELENA
Published: September 2019

The paper deals with «science poetry» concept developed in the late XIX-early XX century by René Gillet and Valery Brusov. The concept was disclosed in V. Brusov’s lectures, his works on literary theory and two collection of verses: «Mea» and «Distant Territories» («Дали»), which are replete with the scientific terms. The paper considers two scholars depicted in «The Fiery Angel», a novel by V. Brusov, Agrip-pa von Nettesheim and Faust, as well as in his other works, primarily, «A Night Trip», etc. The paper concludes that V. Brusov’s creativity pre-empted science fiction.
FOLKLORE IN V. BRUSOV`S AESTHETIC CONCEPT
Authors: AYVAZYAN MARIAM
Published: September 2019

The paper considers V. Brusov’s works on the theory of folklore, his reviews of collection of verses influenced by folklore motives, and his research on peculiarities of the Russian epic verses. The paper also deals with archaic folklore motives in the poet’s works. The author concludes that folklore is an essential component of the poet’s aesthet-ic world view.
V. BRUSOV IN 1916: THE RENOWNED AND THE UNKNOWN
Authors: DANIELYAN ELMIRA
Published: September 2019

The paper considers V. Brusov’s creativity in 1915-1916, the period that stayed out of the critics’ spotlight. In particular, the matter concerns «Collection of Latvian Literature», «Collection of Finnish Literature », «Jewish Anthology», translations from Percy Bysshe Shelly, William Shakespeare, Horace, etc. In 1916 V. Brusov’s translations from Emil Verhaeren were also published. The writer penned over fifty articles and theatre reviews. Another relevant aspect was the research on Alexander Pushkin’s creative heritage.