bluuebunny/crossref_metadata_2025 huggingface dataset:
Disaster Preparedness in Hospitals in the Middle East: An Integrative Literature Review
Authors: Alruwaili Abdullah , Islam Shahidul , Usher Kim
Published: February 2019

Disasters occur rarely but have significant adverse consequences when they do. Recent statistics suggest that millions of lives and billions of US dollars have been lost in the last decade due to disaster events globally. It is crucial that hospitals are well prepared for disasters to minimize their effects. This integrative review study evaluates the preparedness level of hospitals in the Middle East for disasters using the Preferred Reporting Items for Systematic and Meta-Analyses (PRISMA) guidelines. The key terms include disaster preparedness OR disaster management OR emergency response AND Middle East AND hospitals. The study reviews articles published between January 2005 and December 2015, which focused on the hospitals’ preparedness for disasters in the Middle East nations. Based on their meeting 5 eligibility criteria, 19 articles were included in the review. Twelve of the articles focused on both natural and man-made disasters, whereas 6 of them were based on mass casualty events and 1 on earthquake. Thirteen of the reviewed articles ranked the level of preparedness of hospitals for disasters to be generally “very poor,” “poor,” or “moderate,” whereas 6 reported that hospitals were “well” or “very well prepared” for disasters. Factors affecting preparedness level were identified as a lack of contingency plans and insufficient availability of resources, among others. (Disaster Med Public Health Preparedness. 2019;13:806–816).
Topological and almost Borel universality for systems with the weak specification property
Authors: BURGUET DAVID
Published: February 2019

We show that systems with some specification properties are topologically or almost Borel universal, in the sense that any aperiodic subshift with lower entropy may be topologically or almost Borel embedded. This improves, with elementary tools, previous results of Quas and Soo [Ergodic universality of some topological dynamical systems. Trans. Amer. Math. Soc.368 (2016), 4137–4170].
Reduction of pressure losses and increase of mixing in laminar flows through channels with long-wavelength vibrations
Authors: Floryan J. M. , Zandi Sahab
Published: February 2019

Pressure losses and mixing in vibrating channels were analysed. The vibrations in the form of long-wavelength travelling waves were considered. Significant reduction of pressure losses can be achieved using sufficiently fast waves propagating downstream, while significant increase of such losses is generated by waves propagating upstream. The mechanisms responsible for pressure losses were identified and discussed. The interaction of the pressure field with the waves can create a force which assists the fluid movement. A similar force can be created by friction, but only under conditions leading to flow separation. An analysis of particle trajectories was carried out to determine the effect of vibrations on mixing. A significant transverse particle movement takes place, including particle trajectories with back loops. The downstream-propagating out-of-the phase waves provide a large reduction of pressure gradient and significant potential for mixing intensification. Analysis of energy requirements demonstrates that it is possible to identify waves which reduce power requirements, i.e. the cost of actuation is smaller than the energy savings associated with the reduction of pressure gradient. The fast forward moving waves provide an opportunity for the development of alternative propulsion methods which can be more efficient than methods based on the pressure difference.
Time-dependent lift and drag on a rigid body in a viscous steady linear flow
Authors: Candelier Fabien , Mehlig Bernhard , Magnaudet Jacques
Published: February 2019

We compute the leading-order inertial corrections to the instantaneous force acting on a rigid body moving with a time-dependent slip velocity in a linear flow field, assuming that the square root of the Reynolds number based on the fluid-velocity gradient is much larger than the Reynolds number based on the slip velocity between the body and the fluid. As a first step towards applications to dilute sheared suspensions and turbulent particle-laden flows, we seek a formulation allowing this force to be determined for an arbitrarily shaped body moving in a general linear flow. We express the equations governing the flow disturbance in a non-orthogonal coordinate system moving with the undisturbed flow and solve the problem using matched asymptotic expansions. The use of the co-moving coordinates enables the leading-order inertial corrections to the force to be obtained at any time in an arbitrary linear flow field. We then specialize this approach to compute the time-dependent force components for a sphere moving in three canonical flows: solid-body rotation, planar elongation, and uniform shear. We discuss the behaviour and physical origin of the different force components in the short-time and quasi-steady limits. Last, we illustrate the influence of time-dependent and quasi-steady inertial effects by examining the sedimentation of prolate and oblate spheroids in a pure shear flow.
Statistical state dynamics analysis of buoyancy layer formation via the Phillips mechanism in two-dimensional stratified turbulence
Authors: Fitzgerald Joseph G. , Farrell Brian F.
Published: February 2019

Horizontal density layers are commonly observed in stratified turbulence. Recent work (e.g. Taylor & Zhou, J. Fluid Mech., vol. 823, 2017, R5) has reinvigorated interest in the Phillips instability (PI), by which density layers form via negative diffusion if the turbulent buoyancy flux weakens as stratification increases. Theoretical understanding of PI is incomplete, in part because it remains unclear whether and by what mechanism the flux-gradient relationship for a given example of turbulence has the required negative-diffusion property. Furthermore, the difficulty of analysing the flux-gradient relation in evolving turbulence obscures the operating mechanism when layering is observed. These considerations motivate the search for an example of PI that can be analysed clearly. Here PI is shown to occur in two-dimensional Boussinesq sheared stratified turbulence maintained by stochastic excitation. PI is analysed using the second-order S3T closure of statistical state dynamics, in which the dynamics is written directly for statistical variables of the turbulence. The predictions of S3T are verified using nonlinear simulations. This analysis provides theoretical underpinning of PI based on the fundamental equations of motion that complements previous analyses based on phenomenological models of turbulence.
Do All Black Lives Matter Equally to Black People? Respectability Politics and the Limitations of Linked Fate
Authors: Lopez Bunyasi Tehama , Smith Candis Watts
Published: February 2019

Cathy Cohen’s (1999) theory of secondary marginalization helps to explain why the needs of some members of Black communities are not prioritized on “the” Black political agenda; indeed, some groups are ignored altogether as mainstream Black public opinion shifts to the right (Tate 2010). However, the contemporary movement for Black Lives calls for an intersectional approach to Black politics. Its platform requires participants to take seriously the notion that since Black communities are diverse, so are the needs of its members. To what extent are Blacks likely to believe that those who face secondary marginalization should be prioritized on the Black political agenda? What is the role of linked fate in galvanizing support around these marginalized Blacks? To what extent does respectability politics serve to hinder a broader embrace of Blacks who face different sets of interlocking systems of oppression, such as Black women, formerly incarcerated Blacks, undocumented Black people, and Black members of LBGTQ communities in an era marked by Black social movements? We analyze data from the 2016 Collaborative Multi-Racial Post-Election Survey (CMPS) to assess whether all Black lives matter to Black Americans.
Effects of magnesium supplementation on carotid intima–media thickness and metabolic profiles in diabetic haemodialysis patients: a randomised, double-blind, placebo-controlled trial
Authors: Talari Hamid Reza , Zakizade Mehrafrouz , Soleimani Alireza , Bahmani Fereshteh , Ghaderi Amir , Mirhosseini Naghmeh , Eslahi Masoumeh , Babadi Mahtab , Mansournia Mohammad Ali , Asemi Zatollah
Published: February 2019

This study evaluated the effects of Mg administration on carotid intima–media thickness (CIMT), glycaemic control and markers of cardio-metabolic risk in diabetic haemodialysis (HD) patients. This randomised, double-blind, placebo-controlled clinical trial was conducted in fifty-four diabetic HD patients. Participants were randomly divided into two groups to take either 250 mg/d Mg as magnesium oxide (n27) or placebo (n27) for 24 weeks. Mg supplementation resulted in a significant reduction in mean (P<0·001) and maximum levels of left CIMT (P=0·02) and mean levels of right CIMT (P=0·004) compared with the placebo. In addition, taking Mg supplements significantly reduced serum insulin levels (β=–9·42 pmol/l; 95% CI –14·94, –3·90;P=0·001), homoeostasis model of assessment-insulin resistance (β=–0·56; 95 % CI –0·89, –0·24;P=0·001) and HbA1c (β=–0·74 %; 95 % CI –1·10, –0·39;P<0·001) and significantly increased the quantitative insulin sensitivity check index (β=0·008; 95 % CI 0·002, 0·01;P=0·002) compared with the placebo. In addition, Mg administration led to a significant reduction in serum total cholesterol (β=–0·30 mmol/l; 95% CI –0·56, –0·04;P=0·02), LDL-cholesterol (β=–0·29 mmol/l; 95% CI –0·52, –0·05;P=0·01), high-sensitivity C-reactive protein (hs-CRP) (P<0·001) and plasma malondialdehyde (MDA) (P=0·04) and a significant rise in plasma total antioxidant capacity (TAC) levels (P<0·001) compared with the placebo. Overall, we found that taking Mg for 24 weeks by diabetic HD patients significantly improved mean and maximum levels of left and mean levels of right CIMT, insulin metabolism, HbA1c, total cholesterol and LDL-cholesterol, hs-CRP, TAC and MDA levels.
Is iodine deficiency still a problem in sub-Saharan Africa?: a review
Authors: Saha Sanjoy , Abu Brenda A. Z. , Jamshidi-Naeini Yasaman , Mukherjee Upasana , Miller Makenzie , Peng Li-Ling , Oldewage-Theron Wilna
Published: February 2019

Iodine is an essential trace mineral, vital for its functions in many physiological processes in the human body. Both iodine deficiency (ID) and excess are associated with adverse health effects; ID and excess iodine intake have both been identified in sub-Saharan Africa (SSA). The review aims to (1) review the iodine status among populations in SSA until October 2018, and (2) identify populations at risk of excess or inadequate iodine intakes. A systematic search of relevant articles was carried out by a seven-member research team using PubMed, Science Direct and Scopus. A total of twenty-two articles was included for data extraction. Of the articles reviewed, the majority sought to determine the prevalence of iodine status of the study populations; others measured the impact of uncontrolled and unmonitored salt iodisation on iodine excess and tested the effectiveness of water iodisation. Although iodine status varied largely in study populations, ID and excessive iodine intake often coexisted within populations. The implementation of nutrition interventions and other strategies across SSA has resulted in the reduction of goitre prevalence. Even so, goitre prevalence remains high in many populations. Improvements in access to iodised salt and awareness of its importance are needed. The emerging problem of excess iodine intakes, however, should be taken into consideration by policy makers and programme implementers. As excessive iodine intakes may have adverse health effects greater than those induced by iodine deficient diets, more population-based studies are needed to investigate iodine intakes of the different population groups.
Pan-arctic winter drift speeds and changing patterns of sea ice motion: 1979–2015
Authors: Kaur Satwant , Ehn Jens K. , Barber David G.
Published: February 2019

Monthly mean passive microwave-derived sea-ice motion maps for 36 winters (October–April) are used to examine pan-Arctic sea-ice drift speeds and patterns. The mean Arctic Ocean sea-ice motion consists of three well-known primary circulation regimes: the Beaufort Gyre (BG), transpolar drift (TPD), and a motion system from the Kara Sea (KS). The 36-year mean winter sea-ice drift pattern is used to identify the average boundaries between the circulation regimes mentioned above. Regression analyses of the ice drift speed anomalies show statistically significant positive drift speed trends in BG, TPD and KS. Non-significant trends are associated with negative trends of generally weak drift speeds north of the Canadian Arctic and over the Chukchi/East Siberian Shelf. The first three modes of Empirical Orthogonal Functions were found to explain 30.2%, 13.5% and 8.7% of the spatial variance in the mean winter ice drift patterns and highlight the large variability in the ice drift patterns.
The structure of genetic and environmental influences on normative personality, abnormal personality traits, and personality disorder symptoms
Authors: Kendler Kenneth S. , Aggen Steven H. , Gillespie Nathan , Krueger Robert F. , Czajkowski Nikolai , Ystrom Eivind , Reichborn-Kjennerud T.
Published: February 2019

Background

Can the structure of genetic and environmental influences on normative personality traits (NPTs), abnormal personality traits (APTs), and DSM-IV criteria for personality disorders (PD) fit a high or low congruence model positing, respectively, close or more limited etiologic continuity?

Method

Exploratory factor analysis was applied to transformed correlation matrices from Cholesky twin decompositions obtained in OpenMx. In 2801 adult twins from the Norwegian Institute of Public Health Twin Panel, NPTs and APTs were assessed by self-report using the Big Five Inventory (BFI) and PID-5-Norwegian Brief Form (PID-5-NBF), respectively. PDs were assessed at interview using the Structured Interview for DSM-IV Personality (SIDP-IV).

Results

The best model yielded three genetic and three unique environmental factors. Genetic factors were dominated, respectively, by (i) high loadings on nearly all PDs and NPT/APT neuroticism and compulsivity, (ii) negative loadings on NPT agreeableness/conscientiousness and positive loadings on APT/PD measures of antisocial traits, and (iii) negative loadings on NPT extraversion and histrionic PD, and positive loadings on APT detachment and schizoid/avoidant PD. Unique environmental factors were dominated, by (i) high loadings on all PDs, (ii) high loadings on all APT dimensions and NPT neuroticism, and (iii) negative loadings on NPT extraversion and positive loadings on NPT detachment/avoidant PD.

Conclusions

Two genetic and one environmental common factor were consistent with a high congruence model while one genetic and two environmental factors were more supportive of a low congruence model. The relationship between genetic and environmental influences on personality assessed by NPTs, APTs, and PDs is complex and does not fit easily into a low or high congruence model.
The closing process of the ductus arteriosus connecting the left common carotid artery and main pulmonary artery
Authors: Matsuo Kumiyo , Aoki Hisaaki , Kayatani Futoshi
Published: February 2019

An isolated left common carotid artery is very rare, and only 13 cases have been reported thus far. All those cases were accompanied by a right aortic arch and aberrant left subclavian artery, and the connecting vessel between the pulmonary artery and left common carotid artery was thought to be ductal tissue. However, there have been no reports that have followed the natural closure of this vessel. We present a case in whom we could observe the closing process of this vessel at the connection between the left common carotid artery and main pulmonary artery in association with a tetralogy of Fallot.
An Automated Computational Approach for Complete In-Plane Compositional Interface Analysis by Atom Probe Tomography
Authors: Peng Zirong , Lu Yifeng , Hatzoglou Constantinos , Kwiatkowski da Silva Alisson , Vurpillot Francois , Ponge Dirk , Raabe Dierk , Gault Baptiste
Published: February 2019

We introduce an efficient, automated computational approach for analyzing interfaces within atom probe tomography datasets, enabling quantitative mapping of their thickness, composition, as well as the Gibbsian interfacial excess of each solute. Detailed evaluation of an experimental dataset indicates that compared with the composition map, the interfacial excess map is more robust and exhibits a relatively higher resolution to reveal compositional variations. By field evaporation simulations with a predefined emitter mimicking the experimental dataset, the impact of trajectory aberrations on the measurement of the thickness, composition, and interfacial excess of the decorated interface are systematically analyzed and discussed.
PARABOLIC KAZHDAN–LUSZTIG BASIS, SCHUBERT CLASSES, AND EQUIVARIANT ORIENTED COHOMOLOGY
Authors: Lenart Cristian , Zainoulline Kirill , Zhong Changlong
Published: February 2019

We study the equivariant oriented cohomology ring$\mathtt{h}_{T}(G/P)$of partial flag varieties using the moment map approach. We define the right Hecke action on this cohomology ring, and then prove that the respective Bott–Samelson classes in$\mathtt{h}_{T}(G/P)$can be obtained by applying this action to the fundamental class of the identity point, hence generalizing previously known results of Chow groups by Brion, Knutson, Peterson, Tymoczko and others. Our main result concerns the equivariant oriented cohomology theory$\mathfrak{h}$corresponding to the 2-parameter Todd genus. We give a new interpretation of Deodhar’s parabolic Kazhdan–Lusztig basis, i.e., we realize it as some cohomology classes (the parabolic Kazhdan–Lusztig (KL) Schubert classes) in$\mathfrak{h}_{T}(G/P)$. We make a positivity conjecture, and a conjecture about the relationship of such classes with smoothness of Schubert varieties. We also prove the latter in several special cases.
Paternal height has an impact on birth weight of their offspring in a Japanese population: the Japan Environment and Children’s Study
Authors: Takagi K. , Iwama N. , Metoki H. , Uchikura Y. , Matsubara Y. , Matsubara K. , Nishigori H. , Saito M. , Fujiwara I. , Sakurai K. , Kuriyama S. , Arima T. , Nakai K. , Yaegashi N. , Sugiyama T. ,   the Japan Environment and Children’s Study Group
Published: February 2019

This study examines the relationship between paternal height or body mass index (BMI) and birth weight of their offspring in a Japanese general population. The sample included 33,448 pregnant Japanese women and used fixed data, including maternal, paternal and infant characteristics, from the Japan Environment and Children’s Study (JECS), an ongoing nationwide birth cohort study. Relationships between paternal height or BMI and infant birth weight [i.e., small for gestational age (SGA) and large for gestational age (LGA)] were examined using a multinomial logistic regression model. Since fetal programming may be a sex-specific process, male and female infants were analyzed separately. Multivariate analysis showed that the higher the paternal height, the higher the odds of LGA and the lower the odds of SGA in both male and female infants. The effects of paternal BMI on the odds of both SGA and LGA in male infants were similar to those of paternal height; however, paternal height had a stronger impact than BMI on the odds of male LGA. In addition, paternal BMI showed no association with the odds of SGA and only a weak association with the odds of LGA in female infants. This cohort study showed that paternal height was associated with birth weight of their offspring and had stronger effects than paternal BMI, suggesting that the impact of paternal height on infant birth weight could be explained by genetic factors. The sex-dependent effect of paternal BMI on infant birth weight may be due to epigenetic effects.
The contribution of space for a more sustainable earth: leveraging space to achieve the sustainable development goals
Authors: Di Pippo Simonetta
Published: February 2019

Non-technical summary

This article raises awareness of how countries can leverage space and space technologies to achieve the Sustainable Development Goals (SDGs) through concrete examples. Space science, technology and applications can support a range of pro-developmental activities, such as agricultural planning, biodiversity protection, tele-health and disaster management. United Nations Office for Outer Space Affairs (UNOOSA) helps countries to use space technology in all of these areas, through capacity building and partnerships with government and private sector entities to expand access to space, especially for developing countries. This article also outlines the work of UNOOSA in promoting increased participation of women in the space sector and in STEM careers.
Skilful Seasonal Prediction of Ocean Surface Waves in the Atlantic Ocean
Authors: Dobrynin Mikhail , Kleine Tobias , Düsterhus André , Baehr Johanna
Published: February 2019

Ocean surface wave height in the Atlantic Ocean is strongly influenced by the North Atlantic Oscillation (NAO). Here we demonstrate for the first time a skilful seasonal forecast for wave height in the Atlantic Ocean, produced by a seasonal prediction system with an enhanced prediction skill of winter NAO. The improved seasonal prediction skill of the wave height reaches 0.8 in major parts of the North Atlantic. Prediction skill in the Central and South Atlantic is significantly improved due to swell propagation from better represented active wave generation regions in the North Atlantic. By subsampling, the modeling of climatological anomalies of seasonal wave height for strongly positive and negative NAO phases is considerably improved. We demonstrate the potential of an improved, subsampling‐based approach for the dynamical seasonal prediction of waves, specifically for extreme seasons during strong NAO phases, which can be implemented for operational purposes.
Four Major Holocene Earthquakes on the Reelfoot Fault Recorded by Sackungen in the New Madrid Seismic Zone, USA
Authors: Gold Ryan D. , DuRoss Christopher B. , Delano Jaime E. , Jibson Randall W. , Briggs Richard W. , Mahan Shannon A. , Williams Robert A. , Corbett D. Reide
Published: February 2019

Three sequences of well‐documented, major ~M7+ earthquakes (1811–1812, ~1450, and ~900 CE) in the New Madrid seismic zone, USA, contribute significantly to seismic hazard in the region. However, it is unknown whether this <550‐year recurrence interval has been constant throughout the Holocene given limited geomorphic evidence of prior earthquakes. We extend the record of paleoearthquakes along the Reelfoot fault via investigation of ridgetop gravitational failure features, interpreted as sackungen. The sackungen occur in bluffs along the eastern margin of the Mississippi River floodplain and are concentrated near (<15 km) the southwest dipping Reelfoot reverse fault. A paleoseismic trench excavated across sackungen at the Paw Paw site exposed four packages of colluvial sediment that postdate 30‐ to 11‐ka Peoria Loess. We interpret the colluvial packages to have been deposited following episodic failure of the sackungen as a result of strong ground motions from the following sequence of earthquakes: event 4, 1640 ± 1730 BCE; event 3, 270 ± 670 CE; event 2, 1430 ± 380 CE; and event 1, 1810 ± 50 CE (2 sigma). Event timing corresponds to previously documented earthquakes and represents the longest archive of paleoearthquakes on the Reelfoot fault. If the trenched sackungen record all major Reelfoot fault earthquakes, our observations in combination with prior investigations indicate a period of quiescence from at least 11 to 4.4 ka, followed by four major seismic events culminating in the 1811–1812 CE sequence. This clustered earthquake recurrence pattern helps place bounds on seismic hazard and geodynamic models in the New Madrid seismic zone.
On the Morphodynamic Equilibrium of a Short Tidal Channel
Authors: Xu Fan , Coco Giovanni , Tao Jianfeng , Zhou Zeng , Zhang Changkuan , Lanzoni Stefano , D'Alpaos Andrea
Published: February 2019

We set up a two‐dimensional modeling framework to explore the development and the equilibrium configuration of a tidal channel. We consider two types of morphodynamic modeling systems coupling different flow and sedimentation models, to study the feedback mechanisms controlling the morphodynamics of tidal channels. The simulations indicate that the tidal channel first experiences a pseudo equilibrium state, then diverges from it, and finally approaches a dynamic equilibrium. The reason for this behavior is demonstrated analytically using linear perturbation analysis. We identify distinct positive and negative feedbacks that lead the tidal system to a dynamic equilibrium. One of the feedback mechanisms is controlled by the flow momentum balance, while the other one depends on the overall sediment balance. The dynamic equilibrium configurations obtained in the numerical simulations compare favorably with the theoretical equilibrium. Deviations from theory can be explained analyzing the assumptions in the flow and sedimentation models. Moreover, the minimum width‐to‐depth relationship of a tidal channel cross section is derived and is found to be in agreement with field measurements.
Comparisons of High‐Linear Energy Transfer Spectra on the ISS and in Deep Space
Authors: Zeitlin C. , Narici L. , Rios R. R. , Rizzo A. , Stoffle N. , Hassler D. M. , Ehresmann B. , Wimmer‐Schweingruber R. F. , Guo J. , Schwadron N. A. , Spence H. E.
Published: February 2019

In deep space, personnel and equipment are exposed to the space radiation environment in the form of energetic particles, specifically galactic cosmic rays and sporadic solar energetic particle events. Radiation fields resulting from these particles are modified by shielding, but most radiation measurements in deep space have been made with detectors that were unshielded or very lightly shielded. In contrast, the space radiation environment on the International Space Station (ISS) is more complicated, with time‐dependent modification of the incident flux by the geomagnetic field and complex bulk shielding distributions; measured particle spectra inside the ISS are affected by both types of shielding. The geomagnetic field is also responsible for the existence of the South Atlantic Anomaly, a region of trapped energetic protons and electrons, and hence enhanced radiation dose, through which the ISS travels several times per day on average. Here our primary aim is to compare charged‐particle spectra at high linear energy transfer obtained by the Anomalous Long‐Term Effects in Astronauts instrument on ISS during high‐latitude portions of the orbit to data acquired at the same time by the Cosmic Ray Telescope for the Effects of Radiation and Radiation Assessment Detector instruments, both in deep space. The hypothesis being tested is that these spectra are the same, modulo shielding differences, since the effects of the geomagnetic field are expected to be minimal at high latitudes.
Testing Different Tectonic Models for the Source of the Mw 6.5, 30 October 2016, Norcia Earthquake (Central Italy): A Youthful Normal Fault, or Negative Inversion of an Old Thrust?
Authors: Bonini L. , Basili R. , Burrato P. , Cannelli V. , Fracassi U. , Maesano F. E. , Melini D. , Tarabusi G. , Tiberti M. M. , Vannoli P. , Valensise G.
Published: February 2019

We adopted a multidisciplinary approach to investigate the seismotectonic scenario of the 30 October 2016, Mw 6.5, Norcia earthquake, the largest shock of the 2016–2017 central Italy earthquake sequence. First, we used seismological and geodetic data to infer the dip of the main slip patch of the seismogenic fault that turned out to be rather low‐angle (~37°). To evaluate whether this is an acceptable dip for the main seismogenic source, we modeled earthquake deformation using single‐ and multiple‐fault models deduced from aftershock pattern analyses. These models show that the coseismic deformation generated by the Norcia earthquake is coherent with slip along a rather shallow‐dipping plane. To understand the geological significance of this solution, we reconstructed the subsurface architecture of the epicentral area. As the available data are not robust enough to converge on a single fault model, we built three different models encompassing all major geological evidence and the associated uncertainties, including the tectonic style and the location of major décollement levels. In all models the structures derived from the contractional phase play a significant role: from controlling segmentation to partially reusing inherited faults, to fully reactivating in extension a regional thrust, geometrically compatible with the source of the Norcia earthquake. Based on our conclusions, some additional seismogenic sources falling in the eastern, external portions of the Apennines may coincide with inherited structures. This may be a common occurrence in this region of the chain, where the inception of extension is as recent as Middle‐Upper Pleistocene.
A New Model for Esker Formation Sheds Light on the Processes Within Subglacial Tunnels
Authors: Arnold Neil
Published: February 2019

Eskers are long sedimentary ridges that are widespread in current and previously glaciated landscapes. Eskers are believed to form when sediment carried by glacial meltwater gets deposited in subglacial tunnels, which given the importance of subglacial water for ice dynamics means that eskers can provide important information about the shape and dynamics of ice sheets and glaciers. To date, however, no physical model for their formation has been developed. Beaud et al. (2018, https://doi.org/10.1029/2018JF004779) present the first such model; they have linked an existing model for subglacial water flow with one for sediment transport, erosion, and deposition in mixed sediment/bedrock streams. The results of the model add new insights into the conditions which promote esker formation, the rate of supply of sediment to proglacial environments, and also suggest possible links between the water flow regime and the likely esker morphology.
Characterization of a family mutation in the 5’ untranslated region of the endoglin gene causative of hereditary hemorrhagic telangiectasia
Authors: Ruiz-Llorente Lidia , McDonald Jamie , Wooderchak-Donahue Whitney , Briggs Eric , Chesnutt Mark , Bayrak-Toydemir Pinar , Bernabeu Carmelo
Published: February 2019

Hereditary hemorrhagic telangiectasia (HHT) is a vascular disease characterized by nose and gastrointestinal bleeding, telangiectases in skin and mucosa, and arteriovenous malformations in major internal organs. Most patients carry a mutation in the coding region of the endoglin (ENG) or activin A receptor type II-1 (ACVRL1) gene. Nonetheless, in around 15% of patients, sequencing analysis and duplication/deletion tests fail to pinpoint mutations in the coding regions of these genes. In these cases, it has been shown that sequencing of the 5’-untranslated region (5’UTR) of ENG may be useful to identify novel mutations in the ENG non-coding region. Here we report the genetic characterization and functional analysis of the heterozygous mutation c.-142A>T in the 5’UTR region of ENG found in a family with several members affected by HHT. This variant gives rise to a new initiation codon of the protein that involves the change in its open reading frame. Transfection studies in monkey cells using endoglin expression vectors demonstrated that c-142A>T mutation results in a clear reduction in the levels of the endoglin protein. These results support the inclusion of the 5’UTR of ENG in the standard genetic testing for HHT to increase its sensitivity.
In-plane coherent control of plasmon resonances for plasmonic switching and encoding
Authors: Jiang Liyong , Yin Tingting , Dubrovkin Alexander M. , Dong Zhaogang , Chen Yuntian , Chen Weijin , Yang Joel K. W. , Shen Zexiang
Published: February 2019

Absract

Considerable attention has been paid recently to coherent control of plasmon resonances in metadevices for potential applications in all-optical light-with-light signal modulation and image processing. Previous reports based on out-of-plane coherent control of plasmon resonances were established by modulating the position of a metadevice in standing waves. Here we show that destructive and constructive absorption can be realized in metallic nano-antennas through in-plane coherent control of plasmon resonances, which is determined by the distribution rule of electrical-field components of nano-antennas. We provide proof-of-principle demonstrations of plasmonic switching effects in a gold nanodisk monomer and dimer, and propose a plasmonic encoding strategy in a gold nanodisk chain. In-plane coherent control of plasmon resonances may open a new avenue toward promising applications in optical spectral enhancement, imaging, nanolasing, and optical communication in nanocircuits.
Microfluidic reactors for advancing the MS analysis of fast biological responses
Authors: Lazar Iulia M. , Deng Jingren , Stremler Mark A. , Ahuja Shreya
Published: February 2019

The response of cells to physical or chemical stimuli is complex, unfolding on time-scales from seconds to days, with or without de novo protein synthesis, and involving signaling processes that are transient or sustained. By combining the technology of microfluidics that supports fast and precise execution of a variety of cell handling operations, with that of mass spectrometry detection that facilitates an accurate and complex characterization of the protein complement of cells, in this work, we developed a platform that supports (near) real-time sampling and proteome-level capturing of cellular responses to a perturbation such as treatment with mitogens. The geometric design of the chip supports three critical features: (a) capture of a sufficient number of cells to meet the detection limit requirements of mass spectrometry instrumentation, (b) fluid delivery for uniform stimulation of the resident cells, and (c) fast cell recovery, lysis and processing for accurate sampling of time-sensitive cellular responses to a stimulus. COMSOL simulations and microscopy were used to predict and evaluate the flow behavior inside the microfluidic device. Proteomic analysis of the cellular extracts generated by the chip experiments revealed that the identified proteins were representative of all cellular locations, exosomes, and major biological processes related to proliferation and signaling, demonstrating that the device holds promising potential for integration into complex lab-on-chip work-flows that address systems biology questions. The applicability of the chips to study time-sensitive cellular responses is discussed in terms of technological challenges and biological relevance.
Intestinal electrical stimulation attenuates hyperglycemia and prevents loss of pancreatic β cells in type 2 diabetic Goto–Kakizaki rats
Authors: Ouyang Xiaojun , Li Shiying , Tan Yan , Lin Lin , Yin Jieyun , Chen Jiande D. Z.
Published: February 2019

Background/Objective

Recently, intestinal electrical stimulation (IES) has been reported to result in weight loss; however, it is unclear whether it has a therapeutic potential for diabetes. The aim of the present study was to explore the potential hypoglycemic effects of IES and its possible mechanisms involving β cells in diabetic rats.

Subjects/Methods

Diabetic Goto–Kakizaki (GK) rats were chronically implanted with one pair of electrodes in the duodenum. The oral glucose tolerance test (OGTT) and insulin tolerance test (ITT) were performed with or without IES, and plasma glucagon-like peptide-1 (GLP-1) and insulin level were measured. In the other two OGTT sessions, rats were treated with either Exendin (9–39) (GLP-1 antagonist) or Exendin (9–39) plus IES to investigate the underlying mechanism involving GLP-1. Gastric emptying and small intestinal transit were also measured with or without IES. In a chronic study, GK rats were treated with IES or Sham-IES for 8 weeks. Blood glucose, plasma GLP-1 and insulin level, body weight, and food intake were measured. Pancreas weight, islet β-cell apoptosis, and proliferation were also analyzed.

Results

Acute IES reduced blood glucose level from 60 to 120 min during OGTT by 16–20% (all p < 0.05, vs. Sham-IES). GLP-1 antagonist significantly blocked the inhibitory effect of IES on hyperglycemia from 15 to 120 min (all p < 0.05). IES accelerated the small intestinal transit by 15% (p = 0.004). After 8 weeks of chronic stimulation, IES significantly reduced blood glucose (p < 0.05) and body weight (p = 0.02) and increased the plasma GLP-1 concentration (p < 0.05). Furthermore, we observed that chronic IES reduced pancreatic β-cell apoptosis (p = 0.045), but showed no effects on β-cell proliferation.

Conclusions

Our study firstly proved the hypoglycemic effect of IES in a rodent model of type 2 diabetes, possibly attributed to the increasing GLP-1 secretion and improvement in β-cell functions.
Defining the role of Parasutterella, a previously uncharacterized member of the core gut microbiota
Authors: Ju Tingting , Kong Ji Yoon , Stothard Paul , Willing Benjamin P
Published: February 2019

The genus of Parasutterella has been defined as a core component of the human and mouse gut microbiota, and has been correlated with various health outcomes. However, like most core microbes in the gastrointestinal tract (GIT), very little is known about the biology of Parasutterella and its role in intestinal ecology. In this study, Parasutterella was isolated from the mouse GIT and characterized in vitro and in vivo. Mouse, rat, and human Parasutterella isolates were all asaccharolytic and producers of succinate. The murine isolate stably colonized the mouse GIT without shifting bacterial composition. Notable changes in microbial-derived metabolites were aromatic amino acid, bilirubin, purine, and bile acid derivatives. The impacted bile acid profile was consistent with altered expression of ileal bile acid transporter genes and hepatic bile acid synthesis genes, supporting the potential role of Parasutterella in bile acid maintenance and cholesterol metabolism. The successful colonization of Parasutterella with a single environmental exposure to conventional adult mice demonstrates that it fills the ecological niche in the GIT and contributes to metabolic functionalities. This experiment provides the first indication of the role of Parasutterella in the GIT, beyond correlation, and provides insight into how it may contribute to host health.
Neurodevelopmental and behavioral consequences of perinatal exposure to the HIV drug efavirenz in a rodent model
Authors: van de Wijer Lisa , Garcia Lidiane P. , Hanswijk Sabrina I. , Rando Juliette , Middelman Anthonieke , ter Heine Rob , Mast Quirijn de , Martens Gerard J. M. , van der Ven André J. A. M. , Kolk Sharon M. , Schellekens Arnt F. A. , Homberg Judith R.
Published: February 2019

Efavirenz is recommended as a preferred first-line drug for women of childbearing potential living with human immunodeficiency virus. Efavirenz is known for its central nervous system side effects, which are partly mediated by serotonergic actions. The neurotransmitter serotonin exerts neurotrophic effects during neurodevelopment and antenatal exposure to serotonergic agents has been linked to developmental delay. Although the teratogenic risks of efavirenz appear to be minimal, data on long-term developmental effects remain scarce. Here, we aimed to investigate the short- and long-term behavioral and neurodevelopmental effects of perinatal efavirenz exposure. We treated pregnant rats from gestation day 1 until postnatal day 7 with efavirenz (100 mg/kg) or vehicle. We measured behavioral outcomes in male offspring during the first 3 postnatal weeks, adolescence and adulthood, and conducted brain immunohistochemistry analyses after sacrifice. Perinatal efavirenz exposure resulted in reduced body weight and delayed reflex and motor development. During adulthood, we observed a decrease in the total number of cells and mature neurons in the motor cortex, as well as an increase in the number of Caspase-3-positive cells and serotonergic fibers. Together, our data show a developmental delay and persistent changes in the brain motor cortex of rats exposed to efavirenz perinatally. Because over 1 million children born annually are exposed to antiretroviral therapy, our findings underline the need for clinical studies on long-term neurodevelopmental outcomes of perinatal exposure to efavirenz.
p53 induces senescence through Lamin A/C stabilization-mediated nuclear deformation
Authors: Yoon Min-Ho , Kang So-mi , Lee Su-Jin , Woo Tae-Gyun , Oh Ah-Young , Park Soyoung , Ha Nam-Chul , Park Bum-Joon
Published: February 2019

p53-mediated cellular senescence has been intensively investigated, because it is important for tumor suppressive function. In addition, p16/INK4A is well known to be critical for cellular senescence. However, detailed molecular mechanism or relevance between p53 and p16-mediated senescence has not been demonstrated yet. Here we show that p53 induces p16 through Lamin A/C stabilization via direct interaction. Stabilized Lamin A/C promotes degradation of BMI-1 and MEL-18 (Polycomb repressor complex 1, PRC1), which sequesters p16 promotor. Increased p53 can reduce BMI-1/MEL-18 and induce p16 expression via Lamin A/C. Elimination of Lamin A/C can abolish p53-induced p16 expression and BMI-1/MEL-18 reduction. As Lamin A/C expression is increased during cell differentiation, this mechanism seems to be very useful for selective induction of senescence in non-stem cells. Our results suggest that Lamin A/C-p53 network is important for p16/INK4A-mediated cellular senescence.
Necroptosis in primate luteolysis: a role for ceramide
Authors: Bagnjuk Konstantin , Stöckl Jan Bernd , Fröhlich Thomas , Arnold Georg Josef , Behr Rüdiger , Berg Ulrike , Berg Dieter , Kunz Lars , Bishop Cecily , Xu Jing , Mayerhofer Artur
Published: February 2019

The corpus luteum (CL) is a transient endocrine organ, yet molecular mechanisms resulting in its demise are not well known. The presence of phosphorylated mixed lineage kinase domain-like pseudokinase pMLKL(T357/S358) in human and nonhuman primate CL samples (Macaca mulatta and Callithrix jacchus) implied that necroptosis of luteal cells may be involved. In M. mulatta CL, pMLKL positive staining became detectable only from the mid-late luteal phase onwards, pointing to necroptosis during regression of the CL. Cell death, including necroptosis, was previously observed in cultures of human luteal granulosa cells (GCs), an apt model for the study of the human CL. To explore mechanisms of necroptotic cell death in GCs during culture, we performed a proteomic analysis. The levels of 50 proteins were significantly altered after 5 days of culture. Interconnectivity analysis and immunocytochemistry implicated specifically the ceramide salvage pathway to be enhanced. M. mulatta CL transcriptome analysis indicated in vivo relevance. Perturbing endogenous ceramide generation by fumonisin B1 (FB1) and addition of soluble ceramide (C2-CER) yielded opposite actions on viability of GCs and therefore supported the significance of the ceramide pathway. Morphological changes indicated necrotic cell death in the C2-CER treated group. Studies with the pan caspase blocker zVAD-fmk or the necroptosis blocker necrosulfonamid (NSA) further supported that C2-CER induced necroptosis. Our data pinpoint necroptosis in a physiological process, namely CL regression. This raises the possibility that the primate CL could be rescued by pharmacological inhibition of necroptosis or by interaction with ceramide metabolism.
MEK5/ERK5 activation regulates colon cancer stem-like cell properties
Authors: Pereira Diane M. , Gomes Sofia. E. , Borralho Pedro M. , Rodrigues Cecília M. P.
Published: February 2019

Colon cancer has been proposed to be sustained by a small subpopulation of stem-like cells with unique properties allowing them to survive conventional therapies and drive tumor recurrence. Identification of targetable signaling pathways contributing to malignant stem-like cell maintenance may therefore translate into new therapeutic strategies to overcome drug resistance. Here we demonstrated that MEK5/ERK5 signaling activation is associated with stem-like malignant phenotypes. Conversely, using a panel of cell line-derived three-dimensional models, we showed that ERK5 inhibition markedly suppresses the molecular and functional features of colon cancer stem-like cells. Particularly, pharmacological inhibition of ERK5 using XMD8-92 reduced the rate of primary and secondary sphere formation, the expression of pluripotency transcription factors SOX2, NANOG, and OCT4, and the proportion of tumor cells with increased ALDH activity. Notably, this was further associated with increased sensitivity to 5-fluorouracil-based chemotherapy. Mechanistically, ERK5 inhibition resulted in decreased IL-8 expression and NF-κB transcriptional activity, suggesting a possible ERK5/NF-κB/IL-8 signaling axis regulating stem-like cell malignancy. Taken together, our results provide proof of principle that ERK5-targeted inhibition may be a promising therapeutic approach to eliminate drug-resistant cancer stem-like cells and improve colon cancer treatment.
Significant contribution of subseafloor microparticles to the global manganese budget
Authors: Uramoto Go-Ichiro , Morono Yuki , Tomioka Naotaka , Wakaki Shigeyuki , Nakada Ryoichi , Wagai Rota , Uesugi Kentaro , Takeuchi Akihisa , Hoshino Masato , Suzuki Yoshio , Shiraishi Fumito , Mitsunobu Satoshi , Suga Hiroki , Takeichi Yasuo , Takahashi Yoshio , Inagaki Fumio
Published: February 2019

Ferromanganese minerals are widely distributed in subseafloor sediments and on the seafloor in oceanic abyssal plains. Assessing their input, formation and preservation is important for understanding the global marine manganese cycle and associated trace elements. However, the extent of ferromanganese minerals buried in subseafloor sediments remains unclear. Here we show that abundant (108–109 particles cm−3) micrometer-scale ferromanganese mineral particles (Mn-microparticles) are found in the oxic pelagic clays of the South Pacific Gyre (SPG) from the seafloor to the ~100 million-year-old sediments above the basement. Three-dimensional micro-texture, and major and trace element compositional analyses revealed that these Mn-microparticles consist of poorly crystalline ferromanganese oxides precipitating from bottom water. Based on our findings, we extrapolate that 1.5–8.8 × 1028 Mn-microparticles, accounting for 1.28–7.62 Tt of manganese, are globally present in oxic subseafloor sediments. This estimate is at least two orders of magnitude larger than the manganese budget for nodules and crusts on the seafloor. Subseafloor Mn-microparticles thus contribute significantly to the global manganese budget.