bluuebunny/crossref_metadata_2025 huggingface dataset:
PENGARUH PENDIDIKAN, PELATIHAN, DAN PENGALAMAN TERHADAP SKEPTISISME PROFESIONAL AUDITOR
Authors: Nurkholis Nurkholis
Published: August 2020

Professional skepticism is needed by auditors to detect indications of audit fraud and risk. This study aims to examine the effect of education, training, and experience on auditor professional skepticism. This research is based on the theory of cognitive dissonance. The object of this study is the auditor who works at the Public Accounting Firm in Indonesia. Data were collected through a questionnaire and processed using multiple linear regression analysis methods. The test results show that education and experience have a significant positive effect on the level of professional skepticism of auditors. On the other hand, training does not affect the level of auditor professional skepticism. This research provides advice on the development of HR in Public Accounting Firm and curriculum development in educational institutions related to efforts to introduce and add insight to accounting students regarding the importance of applying professional skepticism.Skeptisisme profesional diperlukan oleh auditor untuk mendeteksi indikasi kecurangan dan risiko audit. Penelitian ini bertujuan untuk menguji pengaruh pendidikan, pelatihan, dan pengalaman terhadap skeptisisme profesional auditor. Penelitian ini didasarkan pada teori disonansi kognitif. Objek penelitian ini adalah auditor yang bekerja pada Kantor Akuntan Publik di Indonesia. Data dikumpulkan melalui kuesioner dan diolah menggunakan metode analisis regresi linear berganda. Hasil pengujian menunjukkan bahwa pendidikan dan pengalaman berpengaruh positif signifikan terhadap tingkat skeptisisme profesional pada auditor. Sedangkan pelatihan tidak berpengaruh terhadap tingkat skeptisisme professional auditor. Penelitian ini memberikan saran terhadap pengembangan SDM di KAP dan pengembangan kurikulum di lembaga pendidikan terkait dengan usaha memperkenalkan dan menambah wawasan kepada mahasiswa akuntansi mengenai pentingnya penerapan skeptisisme profesional.
Effectiveness of educational video in improving oral hygiene in preschool students
Authors: Adistia Rinintha , Wafa Wade'ah , Riyanti Eriska , Setiawan Arlette Suzy Puspa Pertiwi
Published: August 2020

Introduction: In recent years, attention has been drawn toward assessing the effectiveness of an oral health education program, especially for preschool students, in order to improve oral hygiene status. There is a difference in the level of ability and learning methods based on age. For early childhood, they tend to imitate the things they see, both people and multimedia images. This research was aimed to analyse the effectiveness of educational video in improving oral hygiene level in preschool students. Methods: This type of research was quasi-experimental with one group pretest-posttest design. The sampling method was the total sampling and obtained 40 subjects. The research population was all students in Al Azhar Kindergarten aged 4-6 years and met the inclusion criteria. Greene and Vermilion Plaque Index was applied to measure the oral hygiene status of each subject before and after the intervention with educational video. The intervention consisted of four meetings; each meeting consisted of before and after plaque index measurement and also after watching the educational video. Data were analysed using t-paired statistical analysis. Results: The result showed a comparison of difference of the plaque index value change on the day I with day VII, which obtained the t-value = 3.365, higher than the t-table = 2.02. Conclusion: Educational video is effective in improving oral hygiene in preschool students by reducing the plaque accumulation.
Teachers’ Strategy in Improving Students’ Learning Achievement of Al-Qur’an and Hadits at Madrasah Tsanawiyah
Authors: Mardiah Mardiah , Askar Askar , Rustina Rustina
Published: August 2020

This study aims to determine the strategies of teachers of the Qur'an and hadith subjects in improving the learning achievement of students in Madrasah Tsanawiyah (MTs) Al-Khairaat Biromaru. The method is qualitative research, with data collection techniques namely; observation, interview and documentation. By using analytical techniques; data collection, data reduction, data presentation and data verification. Data verification uses three methods namely deductive, inductive and comparative. Research results show that by using expository learning strategies with lecture, training or group work methods in teaching it can make it easier for teachers to control students to learn in accordance with the objectives to be achieved in the Al-Khairaat Biromaru Madrasah (MTs) Al-Khairaat Biromaru namely to increase learning achievement. In addition, the selection of media in teaching is also highly considered by Madrasas, especially Madrasah Tsanawiyah (MTs) Al-Khairaat Biromaru because it is one of the determinants to motivate students so that their learning achievement increases, for example in the form of cardboard paper written by the teacher containing verses of Al-qur'an or hadith, or by showing videos that match the material.
The Role of Islamic Education Teachers Competency in Improving the Quality of Education
Authors: Zuhaeriah Zuhaeriah , Ali Moh. , Yusra Yusra
Published: August 2020

This study  discusses  the urgency of the competency of teachers on the subjects of Islamic religious education. This study used descriptive qualitative method  and gather data through  observation, interview, and documentation.  Data analysis was carried out through  reduction, data presentation, and data verification that ended with checking the validity of the data. The results of this study shows that competence of teachers in junior high school is adequate. The role of teachers in improving the quality of teaching, positions which directly determine the success, considering the teacher as a figure who is directly involved in learning in the classroom. All of these roles requires more concrete effort, and directly touch to the needs of students in order to get better the quality of learning.  The efforts made by the Islamic religious education teachers in improving the quality of education including the provision of guidance to students, advice, supervision of students, providing motivation and rewards, using varied teaching methods, and personal approach to students. Supporting factors include the existence of good cooperation from principals, teachers, parents, staff, students and the local community, the infrastructure, the competent teachers, and safe and orderly environment. Inhibiting factors include the lack of instructional media; in this case the writer mean is computer and LCD, the lack of participation and support fromstudents’ parent. As for efforts to deal with is as follows: add computer and LCD and establish good coordination with parents.
Editorial Preface
Authors: Nurdin Nurdin
Published: August 2020

International Journal of Contemporary Islamic Education volume 2 issue 1 offers six   articles covering topics of Islamic education studies. Various issues relating to Islamic education interestingly presented to contribute to the body of knowledge and practices. Academia and practitioners in Islamic education studies may gain insight from reading the articles.

 

The first article is titled “Active Learning Strategies Implementation in Arabic Teaching at Senior High School” written by Asmawati Asmawati, Asy’ari Asy’ari, and Malkan Malkan from Postgraduate studies Institut Agama Islam Negeri Palu. This paper discusses the implementation of  active learning strategy in Arabic teaching at a senior high school in Palu city. The second article is titled “ Teachers’ Strategy in Improving Students’ Learning Achievement  of Al-Qur’an and Hadits  at Madrasah Tsanawiyah” written by Mardiah Mardiah, Askar Askar, and Rustina Rustina.   The paper discussed the strategies of teachers of the Qur'an and hadith subjects in improving the learning achievement of students in Madrasah Tsanawiyah (MTs) Al-Khairaat Biromaru.  The third article is titled “Contribution of Islamic Education Values in Marriage Tradition of Banggai Ethnic, Indonesia” written by Oyan D. Taufik, Sagaf S. Pettalongi, and Sidik Sidik. The paper discusses  the contribution of Islamic education values in marriage according to the customs of the tribe in district of Banggai Bulagi. The fourth paper is tittled “The Role of Environment in Improving Learning Quality:  A Case Study of Al-Istiqamah Modern Islamic Boarding School” written by Rara Pratiwi, Kamaruddin Kamaruddin, and Adawiyah Adawiyah. The paper discusses the role of learning environment in improving the quality of learning students in modern boarding school Al-Istiqamah Ngatabaru. The fifth article is titled “Effectiveness the Use of Audio Visual Media in Teaching Islamic Religious Education” written by Winarto Winarto, Ahmad Syahid, and Fatimah Saguni. The paper discussed  the effectiveness of using audio visual as media in improving learning achievement of a Islamic Junior high school. The last paper  is title “The Role of Islamic Education Teachers Competency in Improving the Quality of Education” written by Zuhaeriah Zuhaeriah, Moh. Ali, and Yusra Yusra. The paper  discusses  the urgency of the competency of teachers on the subjects of Islamic religious education.

 

I hope the articles presented in this issue add further empirical evidence to the growing body of research that examines various fields from Islam perspectives.  The articles could trigger other research to study other field of study with Islam perspectives Islamic institutions in Indonesia. 

 

Nurdin Nurdin

Editor-in-Chief

IJCIED:  International Journal of Contemporary Islamic Education

Volume II, Issue 1
Effectiveness of Marriage Services Through Information System Management (SIMKAH) at Palu City Religious Court
Authors: Muslih Imam , Nurdin Nurdin , Marzuki Marzuki
Published: August 2020

This paper discusses the effectiveness of marriage services through Marriage Management Information System (SIMKAH) at Palu city religious court. This study used qualitative research method. The data was collected through in-depth interview, observation, and document studies. The data was analyzed using grounded theory approach which begins with data reduction, presentation, analysis, and three level coding. The results show that the Marriage Management Information System (SIMKAH) has various purposes and functions. The marriage information system is used to anticipate data manipulation, and to facilitate a spouse in order to better understand how to register. The information system has been effectively used to serve couple who wants to marry. The system also reduce costs of marriage because it reduces time and registration cost.
The Effectiveness of the Implementation of the Principle of Simple Court Procedures, Fast and Low Cost in a Case of Divorce Lawsuit
Authors: Haekal Muhammad , Abidin Abidin , Musyahidah Siti
Published: August 2020

The purpose of this study is to investigate the effectiveness of the implementation of simple, fast and low-cost religious court procedures in the divorce case at the Religious Court, Palu. This study used qualitative research, while the data were collected through observation, interviews and document reviews. The effectiveness of the religious court procedures in regards to topic being investigated was measured through the theory of legal effectiveness. The results of the study showed that the effectiveness of simple, fast and low-cost judicial principles could be effectively achieved due to a simple trial process, continuous revision throughout the process (from registration to decision) and affordable case costs. 2) The factors that support the accountability of the Religious Court when implementing the principles are the existence of a one-stop integrated service system, Electronic Court (E-Court), free litigation, Legal Aid Post and observable court. 3) A simple, fast and low-cost judicial principles have been effective because they have fulfilled the five aspects as stated by Soerjono Soekanto.
Implementing School Policy: Teachers’ Strategies in Improving Students Speaking Ability
Authors: Zakiya Hariratuz , Santoso Riyadi , Nurkamto Joko
Published: August 2020

The problem of learning language skills especially speaking still exists in many educational
institutions in Indonesia. For schools and English teachers, overcoming this problem becomes a huge
challenge because Indonesian learners still underestimate the capability of formal educations also
English teachers to educate them in the right way. This research will investigate the school's policy
and the teachers' strategies in improving students' speaking ability in a Bilingual High School in
Indonesia. The research questions to be are what the school policy is on improving students'
speaking ability, what the teachers' strategies are in implementing the school policy to improve
students' speaking ability. A case study is employed for this research. The data of this research is
taken from an in-depth interview with English teachers and school officials, observation, and
documentation. The techniques of data verification in this research are using triangulation technique
and member check. The purposes of this research are to show the positive teachers’ strategies in
implementing school policy in improving students’ speaking ability.
The diagnostic accuracy of procalcitonin in infectious patients after cardiac surgery: a systematic review and meta-analysis
Authors: Li Qianqin , Zheng Shaoyi , Zhou Peng Yu , Xiao Zezhou , Wang Ruiling , Li Juan
Published: August 2020

Cardiac surgery with cardiopulmonary bypass (CPB) induces an acute inflammatory response that may lead to a systemic inflammatory response syndrome. The interest in procalcitonin (PCT) in the diagnosis of bacterial infection in patients after cardiac surgery remains less defined. The aim of this meta-analysis is to prospectively examine the discriminatory power of PCT as markers of infection in hospitalized patients with after cardiac surgery. The bivariate generalized nonlinear mixed-effect model and the hierarchical summary receiver operating characteristic model were used to estimate the pooled sensitivity, specificity and summary receiver operating characteristic curve. The pooled sensitivity and specificity were 0.81 (95% CI 0.75–0.87) and 0.78 (95% CI 0.73–0.83), respectively. The pooled positive likelihood ratio, and negative likelihood ratio of PCT were 3.74 (95% CI 2.98–4.69) and 0.24 (95% CI 0.17–0.32), respectively. The pooled area under the summary receiver operating characteristic curve of PCT using the HSROC method was 0.87 (95% CI 0.84– 0.90). This study indicated that PCT is a promising marker for the diagnosis of sepsis for those patients who undergo cardiac surgery.
Sacubitril/valsartan use in a real-world population of patients with heart failure and reduced ejection fraction
Authors: Mapelli Massimo , Salvioni Elisabetta , de Martino Fabiana , Mattavelli Irene , Bonomi Alice , Sassi Valentina , Gugliandolo Paola , Vignati Carlo , Magini Alessandra , Rovai Sara , Paolillo Stefania , Agostoni Piergiuseppe
Published: August 2020

Aims

Practice guidelines recommend sacubitril/valsartan for heart failure with reduced ejection fraction. The aim of our study was to describe the use of sacubitril/valsartan in real-world clinical practice to help identify patients best able to tolerate titration to higher doses.

Methods

We retrospectively analyzed clinical data for 201 patients with heart failure with reduced ejection fraction prescribed sacubitril/valsartan at our heart failure clinic (Centro Cardiologico Monzino) between September 2016/December 2018. Patients had a mean age of 67.2 years, mean left ventricular ejection fraction of 30.1%, New York Heart Association class II (65%), class III (35%), and poor cardiopulmonary exercise capacity. Median 2-year risk of death/urgent cardiac transplantation was 8.9% [Metabolic Exercise Cardiac Kidney Index (MECKI) score].

Results

After a median follow-up of 230 (interquartile interval: 105–366) days, 57 patients achieved higher-dose sacubitril/valsartan, 103 tolerated medium/low doses, nine died, and 20 interrupted treatment. The highest dose of sacubitril/valsartan was reached by younger patients with better hemoglobin (Hb) levels, renal function, and blood pressure (BP). Patients continuing on sacubitril/valsartan had significantly higher serum Hb and sodium, better BP, and lower MECKI scores than patients who discontinued treatment or died during follow-up. Our patients were older and frailer than those in the pivotal PARADIGM-HF trial.

Conclusion

In our experience, more than one-third of the patients were able to tolerate the higher dose of sacubitril/valsartan, and these patients were younger, had higher Hb, and better BP and renal function. MECKI score stratification was useful to discriminate patients who continued treatment from those who did not. Future prospective studies should test if these clinical variables can guide the up-titration of sacubitril/valsartan.
Routine minimalist transcatheter aortic valve implantation with local anesthesia only
Authors: Saia Francesco , Palmerini Tullio , Marcelli Chiara , Chiarabelli Matteo , Taglieri Nevio , Ghetti Gabriele , Negrello Fabio , Moretti Carolina , Bruno Antonio Giulio , Compagnone Miriam , Corsini Anna , Castelli Andrea , Marrozzini Cinzia , Galiè Nazzareno
Published: August 2020

Aims

Conscious sedation instead of general anesthesia has been increasingly adopted in many centers for transfemoral transcatheter aortic valve replacement (TAVR). Improvement of materials and operators’ experience and reduction of periprocedural complications allowed procedural simplification and adoption of a minimalist approach. With this study, we sought to assess the feasibility and safety of transfemoral TAVR routinely performed under local anesthesia without on-site anesthesiology support.

Methods

The routine transfemoral TAVR protocol adopted at our center includes a minimalist approach, local anesthesia alone with fully awake patient, anesthesiologist available on call but not in the room, and direct transfer to the cardiology ward after the procedure. All consecutive patients undergoing transfemoral TAVR between January 2015 and July 2018 were included. We assessed the rates of actual local anesthesia-only procedures, conversion to conscious sedation or general anesthesia and 30-day clinical outcomes.

Results

Among 321 patients, 6 received general anesthesia upfront and 315 (98.1%) local anesthesia only. Mean age of the local anesthesia group was 83.2 ± 6.9 years, Society of Thoracic Surgery score 5.8 ± 4.8%. A balloon-expandable valve was used in 65.7%. Four patients (1.3%) shifted to conscious sedation because of pain or anxiety; 6 patients (1.9%) shifted to general anesthesia because of procedural complications. Hence, local anesthesia alone was possible in 305 patients (96.8% of the intended cohort, 95% of all transfemoral procedures). At 30 days, in the intended local anesthesia group, mortality was 1.6%, stroke 0.6%, major vascular complications 2.6%. Median hospital stay was 4 days (IQR 3–7).

Conclusion

Transfemoral TAVR can be safely performed with local anesthesia alone and without an on-site anesthesiologist in the vast majority of patients.
Impact of stent thickness on clinical outcomes in small vessel and bifurcation lesions: a RAIN-CARDIOGROUP VII sub-study
Authors: Franchin Luca , Piroli Francesco , D’Ascenzo Fabrizio , Nuñez-Gil Ivan , Wojakowski Wojciech , Imori Yoichi , Trabattoni Daniela , Huczek Zenon , Venuti Giuseppe , Muscoli Saverio , Montabone Andrea , Rognoni Andrea , Parma Radoslaw , Figini Filippo , Mitomo Satoru , Quadri Giorgio , Wańha Wojciech , Cortese Bernardo , De Filippo Ovidio , Ryan Nicola , Varbella Ferdinando , Sheiban Imad , Helft Gerard , De Ferrari Gaetano M.
Published: August 2020

Background

The clinical impact of stent strut thickness in coronary bifurcation lesions in small vessels has not been assessed in a real-world population.

Methods

All 506 patients enrolled in the RAIN study, undergoing PCI in a vessel with a diameter 2.5 mm or less were retrospectively evaluated and divided into two groups according to stent strut thickness: 74 μm (n = 206) versus 81 μm (n = 300); 87.1% of the lesions involved bifurcations. TLF [defined as a composite of myocardial infarction (MI) and target lesion revascularization (TLR)] was the primary endpoint, with MACE (a composite of death, MI and TLR), its components and stent thrombosis the secondary endpoint.

Results

After 16 (14–18) months, a lower incidence of TLF (4.3 vs. 9.8%, P = 0.026) and ST (1.0 vs. 3.0%, P = 0.042) was seen in the 74 μm group, whereas MACE occurred in 60 of 506 patients, with no statistical difference between the two groups (9.7 vs. 13.3%, P = 0.070). At multivariate analysis, chronic renal failure increased the risk of TLF while thinner strut was an independent protective factor (hazard ratio 0.51, CI 0.17–0.85, P = 0.005).

Conclusion

In this real-world population, patients being treated for small vessels lesions with thinner strut stents had lower rates of TLF, MI and ST.
Inappropriate dose of nonvitamin-K antagonist oral anticoagulants: prevalence and impact on clinical outcome in patients with nonvalvular atrial fibrillation
Authors: Godino Cosmo , Bodega Francesca , Melillo Francesco , Rubino Francesca , Parlati Antonio L.M. , Cappelletti Alberto , Mazzone Patrizio , Mattiello Paolo , Della Bella Paolo , Castiglioni Alessandro , Alfieri Ottavio , De Bonis Michele , Montorfano Matteo , Tresoldi Moreno , Filippi Massimo , Zangrillo Alberto , Salerno Anna , Cera Michela , Margonato Alberto
Published: August 2020

Background

Limited real-world data are available regarding the outcome of patients treated with inappropriate dose of nonvitamin-K antagonist oral anticoagulants (NOACs).

Objective

To assess the prevalence and factors associated with inappropriate dose prescription of NOACs and to evaluate adverse events that come from this inappropriate prescription.

Methods

Single-center multidisciplinary registry including nonvalvular atrial fibrillation patients treated with NOACs. Based on guidelines criteria for dose reduction, two subcohorts were defined as treated with appropriate or inappropriate NOACs dose. Primary efficacy endpoint was 2-year rate of thromboembolic events. Primary safety endpoint was 2-year rate of major bleeding. Event-free survival curves among groups were compared using Cox–Mantel test.

Results

A total of 760 nonvalvular atrial fibrillation patients were included; 32% patients were treated with dabigatran, 34% with apixaban, 24% with rivaroxaban and 10% with edoxaban. An inappropriate dose was prescribed in 96 patients (12.6%), and in most cases (68%) it was too low. Rivaroxaban (15%) and apixaban (18.5%) were the most frequently prescribed with an inappropriate dose. Patients treated with an inappropriate dose were elderly people, with low-creatinine clearance value, who had experienced previous bleeding and with a high CHADS2 VASc score. In 2 years, a trend for higher numbers of thromboembolic events (5.2 vs. 3.3%, P = 0.348) and less major bleeding (2.1 vs. 4.2%, P = 0.316) has been observed in patients with inappropriate NOACs prescriptions.

Conclusion

Nearly 13% of patients were treated with an inappropriate dose of NOACs, in this single-center study. A trend for higher numbers of thromboembolic events was observed in these patients. The results should be considered as hypothesis generating.
Paradoxical effect of fat diet in matrix metalloproteinases induced mitochondrial dysfunction in diabetic cardiomyopathy
Authors: Gliozzi Micaela , Scarano Federica , Musolino Vincenzo , Carresi Cristina , Scarcella Antonino , Nucera Saverio , Scicchitano Miriam , Ruga Stefano , Bosco Francesca , Maiuolo Jessica , Macrì Roberta , Zito Maria Caterina , Oppedisano Francesca , Guarnieri Lorenza , Mollace Rocco , Palma Ernesto , Muscoli Carolina , Mollace Vincenzo
Published: August 2020

Aims

Diabetic cardiomyopathy represents the main cause of death among diabetic people. Despite this evidence, the molecular mechanisms triggered by impaired glucose and lipid metabolism inducing heart damage remain unclear. The aim of our study was to investigate the effect of altered metabolism on the early stages of cardiac injury in experimental diabetes.

Methods

For this purpose, rats were fed a normocaloric diet (NPD) or a high fat diet (HFD) for up to 12 weeks. After the fourth week, streptozocin (35 mg/kg) was administered in a subgroup of both NPD and HFD rats to induce diabetes. Cardiac function was analysed by echocardiography. Matrix metalloproteinases (MMPs) activity and intracellular localization were assessed through zymography and immunofluorescence, whereas apoptotic and oxidative markers by immunohistochemistry and western blot.

Results

Hyperglycaemia or hyperlipidaemia reduced ejection fraction and fractional shortening as compared with control. Unexpectedly, cardiac dysfunction was less marked in diabetic rats fed a hyperlipidaemic diet, suggesting an adaptive response of the myocardium to hyperglycaemia-induced injury. This response was characterized by the inhibition of N-terminal truncated-MMP-2 translocation from endoplasmic reticulum into mitochondria and by superoxide anion overproduction observed in cardiomyocytes under hyperglycaemia.

Conclusion

Overall, these findings suggest novel therapeutic targets aimed to counteract mitochondrial dysfunction in the onset of diabetic cardiomyopathy.
The automated external defibrillator, an underused simple life-saving device: a review of the literature. A joint document from the Italian Resuscitation Council (IRC) and Associazione Italiana di Aritmologia e Cardiostimolazione (AIAC)
Authors: Savastano Simone , Baldi Enrico , Compagnoni Sara , Fracchia Rosa , Ristagno Giuseppe , Grieco Niccolò
Published: August 2020

The role of early defibrillation has been well established as a pivotal ring of the chain of survival since the nineties. In the following years, the scientific evidences about the beneficial role of early defibrillation have grown, and most of all, it has been demonstrated that the main determinant of survival is the time of defibrillation more than the type of rescuer. Early lay defibrillation was shown to be more effective than delayed defibrillation by healthcare providers. Moreover, because of the ease of use of automated external defibrillators (AEDs), it has been shown that also untrained lay rescuers can safely use an AED leading the guidelines to encourage early defibrillation by untrained lay bystanders. Although strong evidence has demonstrated that an increase in AED use leads to an increase in out-of-hospital cardiac arrest (OHCA) survival, the rate of defibrillation by laypeople is quite variable worldwide and very low in some realities. Our review of the literature about lay defibrillation highlights that the AED is a life-saving device as simple and well tolerated as underused.
Management of nonischemic-dilated cardiomyopathies in clinical practice: a position paper of the working group on myocardial and pericardial diseases of Italian Society of Cardiology
Authors: Merlo Marco , Masè Marco , Cannatà Antonio , Zaffalon Denise , Lardieri Gerardina , Limongelli Giuseppe , Imazio Massimo , Canepa Marco , Castelletti Silvia , Bauce Barbara , Biagini Elena , Livi Ugolino , Severini Giovanni M. , Dal Ferro Matteo , Marra Martina Perazzolo , Basso Cristina , Autore Camillo , Sinagra Gianfranco
Published: August 2020

Nonischemic-dilated cardiomyopathy (NIDCM) is an entity that gathers extremely heterogeneous diseases. This awareness, although leading to continuous improvement in survival, has increased the complexity of NIDCM patients’ management. Even though the endorsed ‘red-flags’ approach helps clinicians in pursuing an accurate etiological definition in clinical practice, it is not clear when and how peripheral centers should interact with referral centers with specific expertise in challenging scenarios (e.g. postmyocarditis and genetically determined dilated cardiomyopathy) and with easier access to second-line diagnostic tools and therapies. This position paper will summarize each step in NIDCM management, highlighting the multiple interactions between peripheral and referral centers, from first-line diagnostic workup and therapy to advanced heart failure management and long-term follow-up.
Rationale and design of the EPLURIBUS Study (Evidence for a comPrehensive evaLUation of left ventRicle dysfnctIon By a whole-heart coverage cardiac compUted tomography Scanner)
Authors: Andreini Daniele , Conte Edoardo , Mushtaq Saima , Pontone Gianluca , Guglielmo Marco , Baggiano Andrea , Annoni Andrea , Mancini Maria E. , Formenti Alberto , Nicoli Flavia , Tanzilli Alessandra , Muscogiuri Giuseppe , Magini Alessandra , Agostoni Piergiuseppe , Bartorelli Antonio L. , Fiorentini Cesare , Pepi Mauro
Published: August 2020

Background

Cardiac magnetic resonance (CMR) is the standard of reference for myocardial fibrosis detection by late gadolinium enhancement. Cardiac computed tomography (CCT) is emerging as a promising alternative. The Evidence for a comPrehensive evaLUation of left ventRicle dysfnctIon By a whole-heart coverage cardiac compUted tomography Scanner study will assess the feasibility and diagnostic accuracy of a comprehensive functional and anatomical cardiac evaluation with CCT as compared with CMR and invasive coronary angiography as standard of reference.

Methods

Consecutive patients with a newly diagnosed left ventricle (LV) dysfunction (left ventricular ejection fraction <50%) and a clinical indication to CMR will be screened. Exclusion criteria will be contraindications to contrast agents and impaired renal function. CCT will be performed per protocol within 10 days from CMR. A total of 100 patients will be enrolled within 24 months. We will evaluate with CCT volume and ejection fraction of the LV and right ventricle, presence, extent and pattern of delayed enhancement and cardiac venous system. Moreover, presence and degree of coronary stenoses will be evaluated among patients undergoing invasive coronary angiography in the 6 months following CCT.

Results

The primary study endpoints will be: first, to assess the diagnostic performance of CCT vs. CMR to detect the delayed enhancement in a territory-based and patient-based analysis; second, to assess the agreement between CCT and CMR in the discrimination between ischemic vs. nonischemic delayed enhancement patters in a territory-based analysis; third, to assess the correlation between CCT and CMR for LV and right ventricle end-diastolic and end-systolic volumes and ejection fraction measurements.

Conclusion

The Evidence for a comPrehensive evaLUation of left ventRicle dysfnctIon By a whole-heart coverage cardiac compUted tomography Scanner study will assess the diagnostic performance of CCT using the latest scanner generation for a comprehensive evaluation of patients with new-onset LV dysfunction.
A very long-term observation of a family with dilated cardiomyopathy and overlapping phenotype from lamin A/C mutation
Authors: Porcu Maurizio , Corda Marco , Pasqualucci Daniele , Binaghi Giulio , Sanna Nadia , Matta Gildo , Cossa Stefano , Scalone Antonio , Tola Gianfranco
Published: August 2020

Aims

We aim to describe one of the longest longitudinal follow-ups reported so far (>22 years), concerning a whole family affected by a missense lamin A/C mutation (Arg60Gly), which manifested as an overlapping phenotype with cardiac and extracardiac involvement over time.

Methods

Starting from the family history, two generations of that family were prospectively observed, from 1997 until 2020. At baseline, four individuals with dilated cardiomyopathy and cardiac conduction defects showed the same mutation. This was also found in three young individuals, phenotypically unaffected at baseline assessment.

Results

The prolonged clinical and laboratory evaluation has shown the evolution of an overlapping phenotype in which cardiac alterations have been associated with lipodystrophy and neurological manifestations. In the first observed generation, the prognosis was negatively affected by the progression of heart failure and lipodystrophy, whereas in the second generation the first phenotypic manifestations became evident after the 2nd decade. Cardiac magnetic resonance played a relevant role in the early detection of cardiac alteration. Right bundle branch block was another sign of initial phenotypical expression.

Conclusion

In lamin A/C gene mutation carriers, a strict, multidisciplinary follow-up allows the opportunity to monitor the progress of the disease and to intervene precociously with the best available treatments.
Incidence and mortality risk in coronavirus disease 2019 patients complicated by acute cardiac injury: systematic review and meta-analysis
Authors: Zuin Marco , Rigatelli Gianluca , Zuliani Giovanni , Bilato Claudio , Zonzin Pietro , Roncon Loris
Published: August 2020

Background

The prevalence and prognostic implications of acute cardiac injury (ACI), as a complication of coronavirus disease 2019 (COVID-19), remain unclear.

Objectives

We conducted a systematic review and meta-analysis to investigate the relationship between ACI and mortality risk in COVID-19 patients.

Methods

Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed in abstracting data and assessing validity. We searched MEDLINE, Scopus and Web of Science to locate all articles published up to 10 April 2020 reporting data of COVID-19 survivors and nonsurvivors developing ACI as a complication of the infection. Quality assessment was performed using the Newcastle–Ottawa quality assessment scale. Data were pooled using the Mantel–Haenszel random effects models with odds ratio as the effect measure with the related 95% confidence interval. Statistical heterogeneity between groups was measured using the Higgins I
2 statistic.

Results

Eight studies, enrolling 1686 patients (mean age 59.5 years), met the inclusion criteria and were included in the final analysis. Data regarding the outcome of patients complicated with ACI were available for 1615 patients. Of these, 387 (23.9%) experienced ACIs as COVID-19 complications during the hospitalization. The incidence of ACI was significantly higher among non survivors when compared with survivors (61.6 vs. 6.7%, P < 0.0001). The pooled analysis confirmed a significantly increased risk of death in COVID-19 patients complicated with ACI during the disease (odds ratio: 21.6, 95% confidence interval: 8.6–54.4, P < 0.0001, I
2 = 82%).

Conclusion

Development of ACI during COVID-19 significantly increases the risk of death during the infection.
Clinical characteristics and treatment of Spontaneous Coronary Artery Dissection in Young Women Undergoing Percutaneous Coronary Intervention
Authors: Inoue Yosuke , Tanaka Akihito , Asano Hiroshi , Uemura Yusuke , Takagi Kensuke , Ohashi Taiki , Tanaka Miho , Umemoto Norio , Ajioka Masayoshi , Tashiro Hiroshi , Watarai Masato , Morishima Itsuro , Tatami Yosuke , Takada Yasunobu , Shimizu Kiyokazu , Ishii Hideki , Murohara Toyoaki
Published: August 2020

Background

Spontaneous coronary artery dissection (SCAD) has recently been recognized as a cause of acute coronary syndrome (ACS), especially in young women. However, the characteristics, optimal treatment, and prognosis of patients who experience SCAD have not been fully described.

Methods

Data were retrospectively collected from a multicenter registry. Among 187 young women less than 60 years of age who underwent percutaneous coronary intervention, 19 (10.2%) with SCAD were identified through coronary angiography. Clinical characteristics and outcomes were investigated.

Results

Those with SCAD less frequently exhibited coronary risk factors, such as diabetes, dyslipidemia, and smoking, than those without SCAD. Intense emotional and/or physical stress was more frequently observed as a prominent precipitating factor in cases of SCAD. All 19 SCAD patients presented with ACS, 7 of whom were treated using stents, and the other 12 treated without stents. During a median follow-up of 960 days (interquartile range, 686–1504 days), two recurrent coronary artery dissections occurred within 7 days, both of which occurred in a vessel other than that in which primary dissection occurred. There were no deaths or recurrent dissection after 1 week.

Conclusion

SCAD was not uncommon among young Japanese women requiring percutaneous coronary intervention. Patients with SCAD exhibited fewer coronary risk factors and more precipitating factors than those without SCAD, and long-term clinical outcomes after an early period appeared to be favorable.
Clinical performance of a novel sirolimus-coated balloon in coronary artery disease: EASTBOURNE registry
Authors: Cortese Bernardo , Testa Luca , Di Palma Gaetano , Heang Tay M. , Bossi Irene , Nuruddin Amin A. , Ielasi Alfonso , Tespili Maurizio , Perez Ignacio S. , Milazzo Diego , Benincasa Susanna , Latib Azeem , Cacucci Michele , Caiazzo Gianluca , Seresini Giuseppe , Tomai Fabrizio , Ocaranza Raymundo , Torres Alfonso , Perotto Anna , Bedogni Francesco , Colombo Antonio
Published: August 2020

Aims

The purpose of the EASTBOURNE registry is to evaluate the immediate and long-term clinical performance of a novel sirolimus-coated balloon (SCB) in a real-world population of patients with coronary artery disease. We here present the prespecified interim analysis after the enrollment of the first 642 patients who obtained 1-year clinical follow-up.

Methods

EASTBOURNE is a prospective, international, multicenter, all-comer investigator-driven clinical registry, which is enrolling consecutive patients treated with SCB at 42 European and Asiatic centers. Primary study endpoint is target-lesion revascularization (TLR) at 12 months. Secondary endpoints are procedural success and major adverse cardiac events through 36 months.

Results

Diabetes mellitus was present in 41% of patients. Acute coronary syndrome was present in 45% of patients and de novo lesions were 55%; 83% of the in-stent restenosis (ISR) patients had drug-eluting stents restenosis. Lesion predilatation was performed in 95% of the cases and bailout stenting occurred in 7.5%. So far, 642 patients have a complete 12-month follow-up. TLR occurred in 2.5%, myocardial infarction in 2.3%, total death in 1% and major adverse cardiac events in 5.8% of patients. A prespecified analysis of comparison between ISR and de-novo lesions showed a significantly higher occurrence of TLR in the ISR population (5.4 vs. 0.2%, P = 0.0008).

Conclusion

The current interim analysis of 12-month follow-up of the EASTBOURNE registry shows good immediate performance and an adequate and encouraging safety profile through 12 months for this novel SCB.
Comparison of interpolation methods based on Geographic Information System (GIS) in the spatial distribution of seawater intrusion
Authors: TANJUNG MAULINA , SYAHREZA SAUMI , RUSDI MUHAMMAD
Published: August 2020

The study of monitoring seawater intrusion and groundwater quality in a coastal area needs to be done regularly to prevent the clean water crisis problems in the future. Accurate and reliable interpolation of seawater intrusion over a region is the requirement of an efficient monitoring. In this study, different interpolation methods were investigated and compared to determine the best interpolation method for predicting the spatial distribution of seawater intrusion in the coastal area of Banda Aceh. Groundwater electrical conductivity (EC) was analyzed to identify the contamination of seawater intrusion into the coastal aquifers. Four interpolation methods such as Empirical Bayesian Kriging (EBK), Global Polynomial Interpolation (GPI), Inverse Distance Weighting (IDW), and Local Polynomial Interpolation (LPI), were used to create the spatial distribution of the groundwater electrical conductivity. The accuracy of interpolation methods was evaluated by using a cross-validation technique through the coefficient of determination (R2) and the Root Mean Square Error (RMSE). The results showed that IDW performed the most accurate prediction values and the best surface which were indicated by the least RMSE and the highest R2 value. It can be concluded that IDW interpolation method is the best method for interpolating the groundwater electrical conductivity associated with seawater intrusion in the coastal area of Banda Aceh.
Application of magnetic method for mapping buried structures around archaeological site of Masjid Tuha Indrapuri
Authors: KEUMALA CUT INTAN , AFRIZAL TOMI , SURBAKTI MUHAMMAD SYUKRI , ISMAIL NAZLI
Published: August 2020

Magnetic gradiometer survey has been conducted on the yard of the archaeological site of Masjid Tuha Indrapuri, Aceh Besar Regency, Aceh Province. The site is one of the oldest mosques erected during the Aceh Sultanate period. Magnetic method was applied for mapping archaeological structures buried beneath the surface. Total magnetic field data were measured using Proton Precession Magnetometer with grid spacing of 2 meters between stations covering the entire area of the site. Diurnal and international geomagnetic reference field data were corrected to the measured data in order to calculate total magnetic field anomalies that were influenced by the buried magnetic objects. The total magnetic field anomalies distribution shows two elongated structures with U-shaped patterns surrounding the mosque. The patterns are also revealed in reduction to the pole and derivative vertical filters of the total field anomaly data. The anomaly patterns are considered a response from the rest of the buried fences that were built around the mosque in the past.
Coupling Compost from Chicken Manure and Inorganic Fertilizer to Improve Cassava (Manihot esculenta Crantz) Growth and Yield on a Ferralitic Soil in Côte d‘Ivoire
Authors: Konan Kouakou Marius , Coulibaly Sifolo Seydou , Kouassi Kouadio Ignace , Zoro Bi Irié Arsène , Dogbo Dénezon Odette
Published: August 2020

This study aimed to evaluate the effect of compost from chicken manure, NPK fertilizer and the mixture of both fertilizers on agronomic parameters of four varieties of cassava (Yacé, Bonoua, Six mois and Alleda agba) in Côte d‘Ivoire. The field experiment was carried out under a randomized complete block design with three replicates on a ferralitic soil during two season-cycles. The results showed that the different fertilizers stimulated plants growth and tuberous roots production. The highest number of stems (3) and leaves (66) was obtained with the mixture of NPK and compost applied on the variety “Bonoua”. All varieties that received the compost mixed with NPK produced more leaves with a dominance of the Bonoua variety (65.57). The highest number of tuberous roots (5.58), the heaviest weight per root (6.13 kg) and the highest yield (61.37 t/ha) were obtained while using the mixture of compost and NPK as fertilizer and “Bonoua” as variety. Thus, mixing compost from chicken manure and NPK can be recommended to improve cassava productivity in Côte d'Ivoire on a ferralitic soil.
Orman Alanlarında Kabuk Böceklerinin (Coleoptera: Curculionidae, Scolytinae) Mücadelesinde Monoterpenlerin Kullanımı
Authors: Tiring Gülsevim , Satar Serdar , Özkaya Okan
Published: August 2020

Kabuk böcekleri (Coleoptera: Curculionidae) dünyada ve Türkiye‘de ormanların önemli zararlıları arasındadır. Kabuk böcekleri, monoterpenlerle davranışsal, fizyolojik ve biyokimyasal etki yolu oluşturarak konukçu ağaçlarla kimyasal olarak etkileşime girmektedir. Ormanlarda bulunan çam, ladin ve köknar gibi ağaçlar tarafından üretilen oleoresinin yaklaşık yarısı monoterpenlerdir. Monoterpenler, çam kabuğu böcekleri ve avcıları için davranışsal olarak aktif kairomonlar olarak işlev görmekte ve tritrofik kimyasal iletişimin klasik bir örneğini sunmaktadır. Monoterpenler, kabuk böceklerinin toplanma feromonlarıdır. Kabuk böcekleriyle mücadelede monoterpenler, tuzaklar içerisinde kullanılmaktadır. Myrcene tuzaklarda, sinejist bir etki göstermektedir. Monoterpenler, böcekler için toksik olabilmektedir. Kabuk böceklerine en toksik monoterpenler arasında, limonene bulunmaktadır. Ayrıca monoterpenler ve kabuk böceklerinin avcıları arasında bir ilişki vardır. Monoterpenler, kabuk böceklerinin feromonlarına predatörlerin tepkisini arttırmaktadır.
The Effect of Different Agricultural Wastes on Aroma Composition of Shiitake (Lentinula edodes (Berk.) Pegler) Mushroom
Authors: Baktemur Gökhan , Çelik Zeynep Dilan , Kara Ecem , Taşkın Hatıra
Published: August 2020

Shiitake mushroom (Lentinula edodes (Berk.) Pegler) popular as both edible and medicinal, is one of the most cultivated and consumed mushroom species in the world. Cultivation of this mushroom on different agricultural wastes has been experimented in many studies until today. Nevertheless, agricultural waste trials are going on as agricultural production patterns of the countries are different. In this study, volatile aroma composition of shiitake mushroom produced on different agricultural wastes (wheat stalk, wheat bran, peanut shell, corn cob and vine pruning waste) was compared. Oak sawdust was selected as control because of its common use in literature and substrate materials were mixed at different ratios. In addition, some substrate mixtures were prepared with poplar sawdust. Volatile compounds of the shiitake mushroom were determined by using headspace-solid phase microextraction (HS-SPME) technique combined with Gas Chromatography-Mass Spectrometer (GC-MS). At the end of study, 41 volatile compounds were detected and dimethyl trisulfide, benzaldehyde, dimethyl disulfide, 1-octen-3-ol and 3-octanone were found to be dominant volatile components. Flavour and fragrance of mushrooms are dependent on many volatile aroma compounds and their proportions. While the concentration of eight-carbon components and hydrocarbons was found the highest by using wood straw, amount of sulphur containing compounds and alcohols increased by agricultural wastes in this study. In addition, corn waste positively affected aldehyde compounds.
Comparison of Orchard-grass and Sweet Maize for Doubled Haploid Plant Production via Wide Hybridization in Bread Wheat
Authors: Avcı Süleyman , Kutlu İmren
Published: August 2020

In this study, the potential of haploid regeneration was investigated in hybridization of six bread wheat F1 hybrids known response to another culture with orchard-grass (Dactylis glomerata L.) and sweet maize varieties (Baron, Challenger and Merit). A total of 150 wheat spikes were pollinated with orchard grass and sweet maize and 2730 pseudo-seeds were produced. Although the high rate of developed pseudo-seeds was developed from bread wheat F1 hybrids × orchard-grass, no embryos were produced. Developed pseudo-seeds (2057 number) of bread wheat × sweet maize produced 53 haploid embryos and only 8 of them were regenerated. Developed green plantlets were vernalized and applied colchicine and only four of them produced fertile seeds. The highest rate (5.9) of haploid embryo formation within wheat genotypes was determined in DH20 × Kate A-1. Although the highest haploid embryo formation was observed in Challenger with 3.5% among sweet maize genotypes, it had no effect on plant regeneration. Also, the mixture of pollen of sweet maize varieties increased haploid plant regeneration. It has been observed that some F1 hybrids such as DH20 × Kate A-1 and DH6 × Altay 2000 with low anther response gave better results in terms of haploid embryo formation and regeneration. The means of fertile spike percentages and number of seeds per fertile spike were 26.75% and 9.83, respectively in developed green plants. As a result, bread wheat × sweet maize hybridization will be a good alternative to obtain a homozygous line in a short time in bread wheat genotypes with low anther response.