bluuebunny/crossref_metadata_2025 huggingface dataset:
EDUCAÇÃO MUSICAL E FORMAÇÃO DE PROFESSORES
Authors: Santos Welington Tavares dos
Published: March 2023

Esse artigo apresenta algumas reflexões sobre a educação musical e o processo deformação de professores na Licenciatura em Música. Dialogando com pensadores do passado e dopresente buscou-se ao invés de receitas e respostas, manter uma postura, cuja maior certeza é aconsciência que o homem está em constante e permanente processo de aprendizagem.PALAVRAS-CHAVE: Educação musical, formação de professores e tecnologia.
A LUDICIDADE DO JOGO VOCAL NO DESENVOLVIMENTO DA CONSCIÊNCIA CRIATIVA
Authors: Martins Janaína TrÃ¤sel
Published: March 2023

Este artigo oferece reflexões sobre questões epistemológicas a respeito dodesenvolvimento da consciência vocal-corpórea criativa na formação do ator. Parte-se da hipótesede que através da ludicidade do jogo vocal o aluno desenvolve a consciência sonora em suaplenitude corpórea, energética, imagética, na unidade que permeia as dinâmicas da voz aomovimento do corpo em criatividade artí­stica. Com o foco nos jogos vocais, tais questões sãoestudadas desde o ponto de vista da ludicidade nas relações da técnica vocal com a improvisaçãocorpórea e com o imaginário poético. Os jogos vocais para a prática do ator estão embasados em umfazer pedagógico fundamentado no desenvolvimento da consciência criativa para a composição dadramaturgia do ator.PALAVRAS-CHAVES: jogo vocal, consciência corpóreo-vocal, composição para atores
O ESPECTADOR E A RELAÇÃO DO ENSINO DO TEATRO COM O TEATRO CONTEMPORÂNEO
Authors: Rosseto Robson
Published: March 2023

O objeto de estudo deste artigo é o espectador no âmbito escolar. A discussãopermeia o contexto da contemporaneidade diante da proliferação de propostas distintas nas artescênicas, ressaltando a diversidade das propostas de encenação hoje, que inevitavelmente são osespetáculos que chegam até os alunos. Analiso as implicações referentes a tal recepção econseqüentemente a problemática do professor ao mediar com seus alunos tais encenações.Posteriormente, a discussão aborda possibilidades para o ofí­cio do professor, com reflexõesacerca da recepção de espetáculos teatrais e das atividades em sala de aula.PALAVRAS-CHAVE: recepção, ensino do teatro, espectador.
ESTÁGIO, FORMAÇÃO E DOCÊNCIA EM ARTE: AS MARCAS PRESENTES NOS RELATOS DE UM GRUPO DE ALUNAS
Authors: Vasconcellos Sônia Tramujas
Published: March 2023

O artigo apresenta algumas considerações sobre o estágio na formação deprofessores de artes visuais, centrando a atenção nos relatos das alunas estagiárias. O campo deestudo envolveu a trajetória de um grupo de alunas do quarto ano do turno da manhã do cursode licenciatura em Artes Visuais da Faculdade de Artes do Paraná no ano de dois mil e seis, nadisciplina de prática de ensino e estágio. O intuito foi sobrepor aos choques e conflitosvivenciados no estágio, questionamentos sobre o curso, a disciplina e a escola e possibilidadesde ação. Conclui-se que o estranhamento entre formação e atuação sentido pelas alunas aorealizarem o estágio deve ser um importante elemento desencadeador de atitudes reflexivas,investigativas e processuais no curso de licenciatura em questão.PALAVRAS-CHAVE: estágio, formação inicial, ensino de arte.
O VIOLÃO FLAMENCO E AS FORMAS MUSICAIS FLAMENCAS
Authors: Zanin Fabiano Carlos
Published: March 2023

El Arte Flamenco ganha cada vez mais espaço no panorama musical mundial. Essamanifestação artí­stica espanhola que se realiza por meio do toque, do cante e do baile possui algumascaracterí­sticas de difí­cil compreensão para artistas que não estão inseridos no contexto de suaprodução, a região andaluza. Com a perspectiva de oportunizar uma melhor compreensão da músicaflamenca, este artigo procurou exemplificar e analisar seus principais elementos musicais.PALAVRAS-CHAVE: violão flamenco; análise musical; Flamenco.
UMA LEITURA LITERÁRIA E FÍLMICA DE LAVOURA ARCAICA
Authors: Sirino Salete Paulina Machado
Published: March 2023

Na perspectiva dos Estudos Culturais, promove-se uma reflexão sobre a possibilidade deleitura do discurso literário e fí­lmico de Lavoura Arcaica, respectivamente, de Raduan Nassar e LuizFernando Carvalho, a partir de estudos dos textos Marxismo e Filosofia da Linguagem (1997), deMikhail Bakhtin e a Identidade Cultural na Pós-Modernidade (2002), de Stuart Hall. Tal estudoobjetiva verificar a palavra como geradora de conflitos entre pai e filho e de como a palavra atua comoformadora e/ou transformadora da identidade de ambos.PALAVRAS-CHAVE: Lavoura Arcaica, literatura e cinema, palavra, identidade.
UMA MARCA MACHISTA: O GÊNERO DA OBRA DE POTY
Authors: Buchmann Luciano
Published: March 2023

Este artigo considera o trabalho monumental de Poty Lazzaroto na cidade de Curitiba,produzido ao longo dos 39 anos de sua carreira. A partir de uma perspectiva de gênero, o textoquestiona a manutenção das imagens da mulher e do homem e seus papéis sociais, retratados em seuspainéis como representações do imaginário social moderno caracterí­stico do seu perí­odo de formação.Faz referência a autores da sociologia, pedagogia crí­tica, filosofia polí­tica e estudos culturais.PALAVRAS-CHAVE: Poty Lazzarotto, modernidade, gênero, arte e cultura
COMUNIDADE DE PRÁTICA MUSICAL: UM ESTUDO À LUZ DA TEORIA DE ETIENNE WENGER
Authors: Torres Grace Filipak , Araújo Rosane Cardoso de
Published: March 2023

Em nossa pesquisa, associamos o conceito de "comunidade de prática" deEtienne Wenger com um contexto musical especí­fico: o evento Canja de Viola, realizadohá mais de 20 anos na cidade de Curitiba. A nossa opção metodológica foi realizar umestudo de caso no ambiente da Canja de Viola por meio da utilização de dois instrumentosde coleta de dados em campo: entrevistas e observação participante. Como resultado, foipossí­vel verificar que as relações do conceito de comunidade de prática musical com ocampo em estudo puderam ser observadas, especialmente a partir da análise dos aspectosidentitários e dos dados sobre a prática musical dos participantes do evento.PALAVRAS-CHAVE: comunidade de prática, Canja de Viola, comunidade de práticamusical.
DISPOSITIVOS DA COMUNICAÇÃO: AS IMAGENS COMO PROPOSIÇÕES DO CORPO
Authors: Bittencourt Adriana
Published: March 2023

Este artigo aborda a imagem nos processos de comunicação do corpo, a imagemtratada como um tipo especí­fico de informação. Investiguei as condições para que acomunicação do corpo com o ambiente seja não apenas possí­vel, mas, sobretudo, eficiente.Na pesquisa, tornou-se indispensável tratar corpo e ambiente como fenômenos imersos emprocessos co-evolutivos. Corpo é imagem em fluxo no tempo. Todavia, o corpo não é apenasimagem em movimento. A imagem é um dos modos possí­veis de sua comunicação e a dança,que é tecida pelo movimento, enuncia que corpo e imagem não se descolam.PALAVRAS-CHAVE: imagem; corpo; proposição; movimento.
A presença das imagens nas revistas curitibanas entre 1900-1920
Authors: Kaminski Rosane
Published: March 2023

A expansão das revistas ilustradas que marcou o século XIX europeu logo se espalhou internacionalmente, como parte da modernização que se irradiava para diversos paí­ses. Curitiba também participou desse fenômeno, e no iní­cio do século XX foram editadas mais de sessenta revistas na cidade, muitas delas ilustradas. Neste texto, apresenta-se uma tipologia das funções associadas às imagens publicadas nas revistas curitibanas entre 1900-1920, organizada a partir da observação dos seus perfis editoriais, dos conteúdos veiculados e das especificidades das imagens.Palavras-chave: imagem, revistas ilustradas, Curitiba.
Relações entre literatura e artes gráficas na revista Joaquim: ensaios de análise
Authors: Nunes Fabrício Vaz
Published: March 2023

O presente artigo trata das relações entre artes gráficas e literatura na revista Joaquim, publicada em Curitiba entre os anos de 1946 e 1948, abordando os problemas teóricos pertinentes ao tópico e analisando a articulação entre as diferentes formas artí­sticas em algumas páginas da revista.Palavras-chave: Joaquim, Dalton Trevisan (1925-), Poty Lazarotto (1924-1998), literatura paranaense, arte paranaense
Mosaico do lugar: produçao coletiva na arte pública
Authors: Barboza Leila Maria  da Silva
Published: March 2023

O objeto da pesquisa é a intervenção artí­stica "Mosaico do Lugar", realizada coletivamente para a escada da Rua Oscar Pereira em Chari tas, Niterói, RJ. A ini ciativa partiu da estratégia da autora, artista plástica e coordenado ra do projeto Leila B., para conseguir junto à Prefeitura a urbanização da rua, oferecendo como contrapartida a ação artí­stica coletiva. O presente est udo procura investigar o processo de produção desse mosaico de mosaicos, suas implicaç ões n o plano da urbanidade e as segregações espaciais e socioeconômi cas, utilizando como recorte a cidade de Niterói e os novos planos urbaní­sticos. No plano da produção de arte na esfera pública, propõe uma reflexão entre efemeridade, perenidade e a questão da autoria nas relações que se estabelecem entre art e, art ista e comunidade, enfatizando o quanto essas práticas parecem colocar sob escrutí­nio assunções há muito aceitas e arraigadas no processo de criação artí­stica.Palavras-chave: Arte Pública - Urbanismo - Urbanidade
A criança e o contato com a arte: a experiência da Escola Moderna Dario Vellozo
Authors: Silva Rossano
Published: March 2023

O presente artigo é parte dos estudos que investiga o papel da Arte na concepção pedagógica de Erasmo Pilotto (1910-1992) - intele ctual paranaense responsável por articular as ideias do Movimento pela Escola Nova no Paraná. O recorte do artigo analisa a prática pedagógica de Pilotto e a valorização dada ao contato da criança com o objeto artí­stico na Escola Moderna Dario Vellozo - instituição de caráter experimental que serviu de laboratório ao intelectual.Palavras-chaves: ensino de arte; história intelectual; escolas experimentais.
O diretor-pedagogo
Authors: Haderchpek Robson Carlos
Published: March 2023

Este artigo é resultado da pesquisa de doutorado intitulada: A Poética da Direção Teatral: O diretor-pedagogo e a arte de conduzir processos, desenvolvida no Programa de Pós-Graduação do Instituto de Artes da Unicamp sob a orientação do Prof. Dr. Mareio Aurélio Pires de Almeida. O principal objetivo deste este artigo é realizar uma breve contextualização histórica e trazer à tona uma reflexão acerca da figura do diretor-pedagogo e da constituição de sua poética.Palavras-chave: Teatro; Poética da Direção Teatral; Pedagogia Teatral; Diretor­ Pedagogo.
Arte e espaço público: tensões de uma convivência difí­cil
Authors: Da Rolt Clóvis
Published: March 2023

Este trabalho propõe uma abordagem acerca do teor depreciativo dos argumentos apresentados pelo historiador Voltaire Schilling no artigo "A capital das monstruosidades" , publicado no Jornal Zero Hora de Porto Alegre-RS, no dia 25/10/2009. O referido artigo caiu como uma bomba no meio artí­stico porto-alegrense ao referendar seu desprezo por algumas obras de arte e monumentos instalados em áreas públicas da cidade de Porto Alegre, considerados "monstruosidades" pelo historiador, além de questionar a qualidade estética da arte contemporânea.A reflexão que proponho com este trabalho tenta localizar a ancoragem dos argumentos de Schilling, no sentido de colocar em relevo algumas ideias que sustentam seu ataque às obras de arte e aos monumentos depreciados, bem como analisar o teor das reações que surgiram contra o artigo. Para tanto, num primeiro momento, concentro-me na narratividade midiática do episódio em questão e na forma como o envolvimento da mí­dia jornalí­stica gerou conteúdos discursivos que criaram uma verdadeira disputa estética em torno do tema da "arte pública" . Do ponto de vista metodológico, localizo aspectos discursivos que sustentam o artigo "A capital das monstruosidades" , bem como seleciono e cotejo outros artigos publicados em resposta ao texto do historiador no próprio Jornal Zero Hora. Em seguida, mediante diálogo com autores selecionados, abordo ligeiramente alguns aspectos que podem ser pertinentes ao debate sobre a arte e sua dimensão pública.Palavras-chave: arte; espaço público; juí­zo de valor
Em um Relato do Corpo
Authors: Gomes Eleonora de Araujo
Published: March 2023

Neste artigo reflito a partir da minha pratica artí­stica sobre o processo da pintura: do fazer, dos embates com o suporte, os entornos, as bordas, os vazios, a tinta, a cor, o espaço e sua relação com o mundo comum e o espectador. Através das imagens dos trabalhos afirmo minha trajetória e meus pensamentos no mundo da arte. Palavras chaves: corpo, pintura, fazer
Древний человек из Дманиси 3444. Краниология, реконструкция облика /
ANCIENT MAN FROM DMANISI 3444. CRANIAL STUDY, CRANIOFACIAL RECONSTRUCTION
Authors: Vasilyev S. V. , Veselovskaya E. V. , Grigorieva O. M.
Published: March 2023

Настоящая работа посвящена изучению черепа из Дманиси (Dmanisi D3444/ D3900 (Skull 4)), Грузия. Находка представлена полным черепом с нижней челюстью. Характерной особенностью индивида является практически полное отсутствие зубов на обеих челюстях и значительная атрофия альвеолярных отростков. Краниологические особенности черепа были исследованы по программе угловой морфометрии на широком сравнительном поле ранних гоминид, включая австралопитековых и ранних Homo и молодого представителя того же местонахождения Дманиси (D2700). Черты внешнего облика индивида оценивали по выполненным на краниологической основе графическим и скульптурной реконструкциям. Череп характеризуется значительным развитием рельефа, достаточно большим скуловым диаметром и сильным заорбитным сужением. Многомерный анализ по ряду краниотригонометрических параметров показал, что черепа молодого и старого индивидов из Дманиси довольно сильно различаются и, скорее всего, они не относились к единой популяции. По ряду характеристик Дманисцы похожи на эректоидные формы из Африки и находку Хоббита с острова Флорес. Внешний облик на представленных реконструкциях отличается покатым узким лбом, сильно выступающими скулами, длинной уплощенной верхней губой, заметно выступающим носом с легкой горбинкой.

This work is devoted to the study of a skull from Dmanisi locality (Dmanisi D3444/ D3900 (Skull 4)), Georgia. The find is represented by a complete skull with a lower jaw. A distinctive feature of the individual is the almost complete absence of teeth in both jaws and significant atrophy of the alveolar processes. The skull was studied using the program of angular morphometry against a wide comparative background of early hominids, including Australopithecus and early Homo and a young individual from the same Dmanisi locality (D2700). The appearance of the individual was evaluated according to the graphic and sculptural facial reconstructions from skulls. The skull has strong well‑developed muscular relief, a rather large bizygomatic width and a marked narrowing behind the orbit. Multivariate analysis of a number of craniotrigonometric parameters showed that the skulls of young and old individuals from Dmanisi are quite different and, most likely, they did not belong to a single population. In a number of features, the Dmanisi hominins are similar to the erectoid forms from Africa and to the “Hobbit” from the Flores Island. The appearance on the facial reconstructions is distinguished by a sloping narrow forehead, strongly protruding cheekbones, a long flattened upper lip, and a noticeably protruding nose with a slight hump.
Differential effects of a reading strategy intervention program for migrant children in migrant schools in China
Authors: Guo Qian , Kim Young-Suk , Liu Yan , Peng Yan , Sun Wenkai , Yan Jin , Yang Li
Published: March 2023

Background

There are over 14 million migrant children in the compulsory education system in China and the number has been increasing rapidly. However, the quality of education in schools for migrant children is often poor. Meanwhile, numerous studies indicated the importance of reading skills developed by the end of third grade. Few studies, however, have investigated the early reading development of migrant children in migrant schools in China. In the current study, we examined, with a randomized control trial design, the effects of reading strategy instruction via teacher professional development for migrant children in migrant schools.

Method

A total of 1,679 students from 47 third-grade classes in 13 migrant schools for migrant children in Beijing, China, participated in the study. The intervention was composed of teacher professional development on reading strategy. Students in both treatment and control conditions received books for independent reading.

Results

The program resulted in a higher overall reading performance for students in the treatment classes than those in the control classes, with the difference larger in inferential comprehension and for students who did not live in Beijing before starting elementary school (which we speculate captures the degree of family mobility and the rural–urban gap in the access to educational resources).

Conclusion

The results suggest that a reading strategy instruction via teacher professional development may promote the reading development of migrant children in migrant schools in China.
Computational analysis of the flexibility in the disordered linker region connecting LIM domains in cysteine–glycine-rich protein
Authors: Chauhan Pankaj Kumar , Sowdhamini R.
Published: March 2023

One of the key proteins that are present in the Z-disc of cardiac tissues, CSRP3, has been implicated in dilated and hypertrophic cardiomyopathy leading to heart failure. Although multiple cardiomyopathy-related mutations have been reported to reside on the two LIM domains and the disordered regions connecting the domains in this protein, the exact role of the disordered linker region is not clear. The linker harbors a few post-translational modification sites and is expected to be a regulatory site. We have carried out evolutionary studies on 5614 homologs spanning across taxa. We also performed molecular dynamics simulations of full-length CSRP3 to show that the length variations and conformational flexibility of the disordered linker could provide additional levels of functional modulation. Finally, we show that the CSRP3 homologs with widely different lengths of the linker regions could display diversity in their functional specifications. The present study provides a useful perspective to our understanding of the evolution of the disordered region between CSRP3 LIM domains.
The potential value of Notch1 and DLL1 in the diagnosis and prognosis of patients with active TB
Authors: Xie Jinling , Chen Yinzhong , Chen Shihao , Long Huaquan , Zhang Weijian , Liu Guoan
Published: March 2023

Objectives

The Notch signaling pathway has been implicated in the pathogenesis of active tuberculosis (TB), and Th1-type cell-mediated immunity is essential for effective control of mycobacterial infection. However, it remains unclear whether Notch signaling molecules (Notch1, DLL1, and Hes1) and Th1-type factors (T-bet and IFN-γ) can serve as biomarkers for tracking the progression of active TB at different stages along with peripheral blood white blood cell (WBC) parameters.

Methods

A total of 60 participants were enrolled in the study, including 37 confirmed TB patients (mild (n=17), moderate/severe (n=20)) and 23 healthy controls. The mRNA expression of Notch1, DLL1, Hes1, T-bet and IFN-γ in the peripheral blood mononuclear cells (PBMCs) of the subjects was measured by RT-qPCR, then analyzed for differences. Receiver Operating Characteristic curve (ROC) was used to assess the effectiveness of each factor as a biomarker in identifying lung injury.

Results

We found that mRNA expression levels of Notch1, DLL1, and Hes1 were upregulated in active TB patients, with higher levels observed in those with moderate/severe TB than those with mild TB or without TB. In contrast, mRNA levels of T-bet and IFN-γ were downregulated and significantly lower in mild and moderate/severe cases. Furthermore, the combiROC analysis of IFN-γ and the percentage of lymphocytes (L%) among WBC parameters showed superior discriminatory ability compared to other factors for identifying individuals with active TB versus healthy individuals. Notably, Notch pathway molecules were more effective than Th1-type factors and WBC parameters in differentiating mild and moderate/severe cases of active TB, particularly in the combiROC model that included Notch1 and Hes1.

Conclusions

Our study demonstrated that Notch1, Hes1, IFN-γ, and L% can be used as biomarkers to identify different stages of active TB patients and to monitor the effectiveness of treatment.
Non-coding RNAs derived from the foot-and-mouth disease virus genome trigger broad antiviral activity against coronaviruses
Authors: Rodríguez-Pulido Miguel , Calvo-Pinilla Eva , Polo Miryam , Saiz Juan-Carlos , Fernández-González Raúl , Pericuesta Eva , Gutiérrez-Adán Alfonso , Sobrino Francisco , Martín-Acebes Miguel A. , Sáiz Margarita
Published: March 2023

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of a potentially severe respiratory disease, the coronavirus disease 2019 (COVID-19), an ongoing pandemic with limited therapeutic options. Here, we assessed the anti-coronavirus activity of synthetic RNAs mimicking specific domains in the non-coding regions of the foot-and-mouth disease virus (FMDV) genome (ncRNAs). These molecules are known to exert broad-spectrum antiviral activity in cell culture, mice and pigs effectively triggering the host innate immune response. The ncRNAs showed potent antiviral activity against SARS-CoV-2 after transfection in human intestinal Caco-2 and lung epithelium Calu-3 2B4 cells. When the in vivo efficacy of the FMDV ncRNAs was assessed in K18-hACE2 mice, administration of naked ncRNA before intranasal SARS-CoV-2 infection significantly decreased the viral load and the levels of pro-inflammatory cytokines in the lungs compared with untreated infected mice. The ncRNAs were also highly efficacious when assayed against common human HCoV-229E and porcine transmissible gastroenteritis virus (TGEV) in hepatocyte-derived Huh-7 and swine testis ST cells, respectively. These results are a proof of concept of the pan-coronavirus antiviral activity of the FMDV ncRNAs including human and animal divergent coronaviruses and potentially enhance our ability to fight future emerging variants.
Ghana’s progress towards measles elimination: Surveillance data analysis, Greater Accra Region, 2015 – 2019
Authors: Sheriff Amara Alhaji , Zakariah Adam , Dapaa Samuel , Odikro Magdalene A. , Issahaku Razak G. , Bandoh Delia , Noora Charles L. , Gebru Gebrekrstos N. , Kenu Ernest
Published: March 2023

Introduction

Although measles is targeted for global elimination by 2020, an estimated 869,770 measles cases and 207,500 deaths occurred in 2019. Ghana adopted the World Health Organization measles elimination strategies, however, evidence of a systematic, comprehensive analysis of data tracking progress towards elimination is sparse. We analyzed measles data to describe its epidemiology, surveillance, and vaccination coverage performances in the Greater Accra Region.

Methods

We reviewed and conducted a descriptive analysis of measles surveillance, laboratory, and vaccination data for 2015 to 2019 obtained from the regional health directorate and National public health reference laboratory. Case patients’ demographic and clinical variables were analyzed into frequencies, proportions, and rates. We used WHO measles elimination performance targets; at least one suspected measles case reported per 100,000 population, 80% of suspected measles cases investigated with adequate blood samples, measles incidence <1/1,000,000 population, 95% routine vaccination coverage and during SIAs as benchmarks.

Results

Of 930 suspected measles cases reported, 605(65.1%) were tested. Males accounted for 356(58.8%); 141(23.3%), 342(56.5%), and 122(20.2%), were children <1, 1–4, and ≥5 years old respectively. Of those tested, 10(1.65%) were measles IgM confirmed, of which 7(70.0%) had received at least one dose of measles vaccine. Annualized measles reporting rate ranged from 1.8 to 6.4 per 100,000 population from 2015 to 2019. District specimen collection rate was 100%, and measles incidence was between 0 – 0.6 per million population in the period 2015–2019. Measles vaccination coverage increased from 73.5% in 2016 to 102% in 2019 with 75% of districts achieving 95% coverage in 2019.

Conclusion

The measles case-based surveillance system and vaccination program in the Greater Accra region showed an increasing level of performance towards Ghana’s elimination status. However, performance in laboratory testing of blood specimens was suboptimal. Authorities of Ghana’s health system should strengthen laboratory capacity for prompt diagnosis of measles.
Primary intestinal type mucinous adenocarcinoma of the ovary diagnosed during pregnancy – Maternal and neonatal treatment and outcomes: A case report
Authors: Hase Eliane Azeka , Shinohara Henrique Norio , Alves Filho João Alberto Garcia , Sadalla José Carlos , Ab́saber Alexandre Muxfeldt , Francisco Rossana Pulcineli Vieira
Published: March 2023

The incidence of ovarian cancer during pregnancy is low. Most adnexal tumors removed during pregnancy are benign, with ovarian carcinomas found in approximately 1: 10,000–1: 50,000 pregnancies. Literature on this disease is scarce and consists mostly of retrospective studies and case reports. We report the case of a pregnant patient who presented with a primary intestinal-type mucinous adenocarcinoma of the ovary and underwent unilateral salpingo-oophorectomy, with no additional surgical or chemotherapy treatment after the histological diagnosis, despite an infiltrative stromal invasion pattern. To the best of our knowledge, no such case has been previously reported. Conservative treatment in this case of early ovarian carcinoma is possible during pregnancy and should be performed in the Department of Gynecological Oncology and Obstetrics of a tertiary referral hospital. Given the possibility of disease recurrence, such patients require strict clinical oncological surveillance, specialized prenatal care, and assistance from a multidisciplinary team to improve the maternal and perinatal outcomes.
Mapping topography and network of brain injury in patients with disorders of consciousness
Authors: Liyana Arachige Manoj , Seneviratne Udaya , John Nevin , Ma Henry , Phan Thanh G.
Published: March 2023

Background

There is a growing interest in the topography of brain regions associated with disorders of consciousness. This has caused increased research output, yielding many publications investigating the topic with varying methodologies. The objective of this study was to ascertain the topographical regions of the brain most frequently associated with disorders of consciousness.

Methods

We performed a cross-sectional text-mining analysis of disorders of consciousness studies. A text mining algorithm built in the Python programming language searched documents for anatomical brain terminology. We reviewed primary PubMed studies between January 1st 2000 to 8th February 2023 for the search query “Disorders of Consciousness.” The frequency of brain regions mentioned in these articles was recorded, ranked, then built into a graphical network. Subgroup analysis was performed by evaluating the impact on our results if analyses were based on abstracts, full-texts, or topic-modeled groups (non-negative matrix factorization was used to create subgroups of each collection based on their key topics). Brain terms were ranked by their frequency and concordance was measured between subgroups. Graphical analysis was performed to explore relationships between the anatomical regions mentioned. The PageRank algorithm (used by Google to list search results in order of relevance) was used to determine global importance of the regions.

Results

The PubMed search yielded 24,944 abstracts and 3,780 full texts. The topic-modeled subgroups contained 2015 abstracts and 283 full texts. Text Mining across all document groups concordantly ranked the thalamus the highest (Savage score = 11.716), followed by the precuneus (Savage score = 4.983), hippocampus (Savage score = 4.483). Graphical analysis had 5 clusters with the thalamus once again having the highest PageRank score (PageRank = 0.0344).

Conclusion

The thalamus, precuneus and cingulate cortex are strongly associated with disorders of consciousness, likely due to the roles they play in maintaining awareness and involvement in the default mode network, respectively. The findings also suggest that other areas of the brain like the cerebellum, cuneus, amygdala and hippocampus also share connections to consciousness should be further investigated.
Proposal for a Two-Tier Re-classification of Stage IV/M1 domain of Renal Cell Carcinoma into M1 (“Oligometastatic”) and M2 (“Polymetastatic”) subdomains: Analysis of the Registry for Metastatic Renal Cell Carcinoma (REMARCC)
Authors: Meagher Margaret F. , Mir Maria C. , Minervini Andrea , Kriegmair Maximilian , Heck Matthias , Porpiglia Francesco , Van Bruwaene Siska , Linares Estefania , Hevia Vital , D’Anna Maurizio , Veccia Alessandro , Roussel Eduard , Claps Francesco , Palumbo Carlotta , Marchioni Michele , Afari Jonathan , Saitta Cesare , Liu Franklin , Rubio Jose , Campi Riccardo , Mari Andrea , Amiel Thomas , Checcucci Enrico , Musquera Mireia , Guruli Georgi , Pavan Nicola , Albersen Maarten , Antonelli Alessandro , Klatte Tobias , Autorino Riccardo , McKay Rana R. , Derweesh Ithaar H.
Published: March 2023

Purpose

We hypothesized that two-tier re-classification of the “M” (metastasis) domain of the Tumor-Node-Metastasis (TNM) staging of Renal Cell Carcinoma (RCC) may improve staging accuracy than the current monolithic classification, as advancements in the understanding of tumor biology have led to increased recognition of the heterogeneous potential of metastatic RCC (mRCC).

Methods

Multicenter retrospective analysis of patients from the REMARCC (REgistry of MetAstatic RCC) database. Patients were stratified by number of metastases into two groups, M1 (≤3, “Oligometastatic”) and M2 (>3, “Polymetastatic”). Primary outcome was overall survival (OS). Secondary outcomes were cancer-specific survival (CSS). Cox-regression and Kaplan-Meier (KMA) analysis were utilized for outcomes, and receiver operating characteristic analysis (ROC) was utilized to assess diagnostic accuracy compared to current “M” staging.

Results

429 patients were stratified into proposed M1 and M2 groups (M1 = 286/M2 = 143; median follow-up 19.2 months). Cox-regression revealed M2 classification as an independent risk factor for worsened all-cause mortality (HR=1.67, p=0.001) and cancer-specific mortality (HR=1.74, p<0.001). Comparing M1-oligometastatic vs. M2-polymetastatic groups, KMA revealed significantly higher 5-year OS (36% vs. 21%, p<0.001) and 5-year CSS (39% vs. 17%, p<0.001). ROC analyses comparing OS and CSS, for M1/M2 reclassification versus unitary M designation currently in use demonstrated improved c-index for OS (M1/M2 0.635 vs. unitary M 0.500) and CSS (M1/M2 0.627 vs. unitary M 0.500).

Conclusion

Subclassification of Stage “M” domain of mRCC into two clinical substage categories based on metastatic burden corresponds to distinctive tumor groups whose oncological potential varies significantly and result in improved predictive capability compared to current staging.
Case report: Identification of atypical mantle cell lymphoma with CCND3 rearrangement by next-generation sequencing
Authors: Dai Luomengjia , Zhang Han , Chen Wen , Xia Yi , Qin Shuchao , Shao Yang , Li Jianyong , Miao Yi , Li Bingzong , Zhu Huayuan
Published: March 2023

The t(11;14) (q13;q32) translocation resulting in overexpression of cyclin D1 is the major oncogenic mechanism in mantle cell lymphoma (MCL). Most MCLs can be diagnosed based on morphological features, cyclin D1 expression, and IGH/CCND1 rearrangement. However, in some atypical cases where conventional FISH studies fail to detect IGH/CCND1 rearrangement or immunohistochemistry for cyclin D1 is negative, the diagnosis of the disease can be difficult. Hence, next-generation sequencing (NGS) may allow the identification of molecular alterations and assist in the diagnosis of atypical MCL. In this study, we reported a case of a patient diagnosed as asymptomatic MCL who presented with lymphadenopathy during the initial assessment. A lymph node biopsy was performed and the results revealed a high Ki67 index. However, initial diagnosis of aggressive MCL was difficult since the IGH/CCND1 rearrangement result was negative. Ultimately, by the aid of NGS we identified a rare CCND3 rearrangement in the patient, which lead to overexpression of cyclin D3, thereby facilitating the diagnosis of MCL.
How do serum lipid levels change and influence progression-free survival in epithelial ovarian cancer patients receiving bevacizumab treatment?
Authors: Huang Xiaoyu , Huang Yong , Li Ping
Published: March 2023

Background

This study aimed to investigate how serum lipid levels affect epithelial ovarian cancer (EOC) patients receiving bevacizumab treatment and to develop a model for predicting the patients’ prognosis.

Methods

A total of 139 EOC patients receiving bevacizumab treatment were involved in this study. Statistical analysis was used to compare the median and average values of serum lipid level variables between the baseline and final follow-up. Additionally, a method based on machine learning was proposed to identify independent risk factors for estimating progression-free survival (PFS) in EOC patients receiving bevacizumab treatment. A PFS nomogram dividing the patients into low- and high-risk categories was created based on these independent prognostic variables. Finally, Kaplan–Meier curves and log-rank tests were utilized to perform survival analysis.

Results

Among EOC patients involved in this study, statistical analysis of serum lipid level variables revealed a substantial increase in total cholesterol, triglycerides, apolipoprotein A1, and free fatty acids, and a significant decrease in apolipoprotein B from baseline to final follow-up. Our method identified FIGO stage, combined chemotherapy regimen, activated partial thromboplastin time, globulin, direct bilirubin, free fatty acids, blood urea nitrogen, high-density lipoprotein cholesterol, and triglycerides as risk factors. These risk factors were then included in our nomogram as independent predictors for EOC patients. PFS was substantially different between the low-risk group (total score < 298) and the high-risk group (total score ≥ 298) according to Kaplan–Meier curves (P < 0.05).

Conclusion

Serum lipid levels changed variously in EOC patients receiving bevacizumab treatment. A prediction model for PFS of EOC patients receiving bevacizumab treatment was constructed, and it can be beneficial in determining the prognosis, selecting a treatment plan, and monitoring these patients’ long-term care.
Nutritional impact of CFTR modulators in children with cystic fibrosis
Authors: Gaschignard Margaux , Beaufils Fabien , Lussac-Sorton Florian , Gallet Pauline , Clouzeau Haude , Menard Joris , Costanzo Aurélie , Nouard Lucie , Delhaes Laurence , Tetard Candice , Lamireau Thierry , Fayon Michael , Bui Stéphanie , Enaud Raphaël
Published: March 2023

Background

Nutritional status is a major prognostic factor for breathing and the survival of patients with cystic fibrosis (CF). Since 2012, the development of CFTR modulators has considerably transformed the outcome of this disease. Indeed, both lung function and body mass index are improved by CFTR modulators, such as Lumacaftor/Ivacaftor. However, few data exist regarding the outcome of nutritional intakes under Lumacaftor/Ivacaftor.

Methods

We conducted a prospective single-center study in children with CF treated with Lumacaftor/Ivacaftor to evaluate their nutritional intake before and after treatment

Results

Thirty-four children were included in this study, with a median age of 12.4 years [11.9; 14.7]. There was no significant improvement in weight, height or BMI. Patients' total energy intake was not significantly changed with Lumacaftor/Ivacaftor, while carbohydrate intakes decreased significantly. We found that blood levels of vitamin E and Selenium were significantly increased under Lumacaftor/Ivacaftor, without a significant increase in supplementation. In patients with a BMI Z-score < 0 at treatment initiation, there was a significant improvement in weight and BMI Z-score, while TEI and carbohydrate intakes were significantly lower.

Conclusion

We showed that treatment with Lumacaftor/Ivacaftor improved the nutritional status of patients without necessarily being associated with an increase in nutritional intake. Although these data need to be confirmed in larger cohorts, they support the hypothesis that weight gain under modulators is multifactorial, and may be related to a decrease in energy expenditure or an improvement in absorption.
Identification of QTL controlling volatile terpene contents in tea plant (Camellia sinensis) using a high-aroma ‘Huangdan’ x ‘Jinxuan’ F1 population
Authors: Chen Si , Li Xuanye , Liu Yujie , Chen Jiedan , Ma Jianqiang , Chen Liang
Published: March 2023

Aroma is an important factor affecting the character and quality of tea. The improvement of aroma trait is a crucial research direction of tea plant breeding. Volatile terpenes, as the major contributors to the floral odors of tea products, also play critical roles in the defense responses of plants to multiple stresses. However, previous studies have largely focused on the aroma formation during the manufacture of tea or the comparison of raw tea samples. The mechanisms causing different aroma profiles between tea cultivars have remained underexplored. In the current study, a high-density genetic linkage map of tea plant was constructed based on an F1 population of ‘Huangdan’ × ‘Jinxuan’ using genotyping by sequencing. This linkage map covered 1754.57 cM and contained 15 linkage groups with a low inter-marker distance of 0.47 cM. A total of 42 QTLs associated with eight monoterpene contents and 12 QTLs associated with four sesquiterpenes contents were identified with the average PVE of 12.6% and 11.7% respectively. Furthermore, six candidate genes related to volatile terpene contents were found in QTL cluster on chromosome 5 by RNA-seq analysis. This work will enrich our understanding of the molecular mechanism of volatile terpene biosynthesis and provide a theoretical basis for tea plant breeding programs for aroma quality improvement.
Relationship of epilepsy on the linguistic-cognitive profile of children with ASD: A systematic review of the literature
Authors: Cano-Villagrasa Alejandro , Moya-Faz Francisco José , López-Zamora Miguel
Published: March 2023

Introduction

The prevalence of comorbidity between epilepsy and Autism Spectrum Disorder (ASD) in the pediatric age increased significantly in recent years. The onset of epilepsy negatively influences the abilities of the user with ASD. Thus, epilepsy will be a disabling factor that will reduce the cognitive-linguistic skills of users with ASD. The main objective of this work is to review the current scientific literature and to compare the relationship of epilepsy on the development of cognitive and linguistic skills of children with ASD.

Methods

In this regard, a systematic search was carried out in the main sources (Medline, PubMed, WOS, ResearchGate and Google Scholar). 481 articles were identified, from which, after meeting the different inclusion and exclusion criteria, a total of 18 studies of relevance to the objectives of this work were selected.

Results

The results reflect that, at a global level, epilepsy significantly influences the performance of cognitive- linguistic skills in people with ASD.

Discussion

In conclusion, epilepsy in the ASD population leads to a reduction in cognitive and linguistic abilities, which respond to the different types of epilepsy and their location, significantly impacting the quality of life and basic activities of daily living of the user with ASD.
The role of system justification theory in support of the government under long-term conservative party dominance in Japan
Authors: Nakagoshi Mizuki , Inamasu Kazunori
Published: March 2023

The applicability of system justification theory (SJT) in Japan, where political contexts differ from those in Western countries, was evaluated in this study. SJT explains the psychological mechanisms underlying conservatism. Japan, which has a relatively long history as a democracy among East Asian countries, has a special political context. For instance, (1) it has had almost uninterrupted conservative governance since the end of World War II; and (2) unlike Western countries, opinions on economic issues are not clearly linked to conservative attitudes. A web survey of Japanese voters (n = 1,428) revealed that high general system justification (GSJ) and economic system justification (ESJ) were correlated with conservatism. Further, path analysis results showed that GSJ and ESJ predicted conservative attitudes. Additional analysis suggested that the status-legitimacy hypothesis, in which lower status groups have higher system justification motives, is not supported.
A conceptual model for building program sustainability in public health settings: Learning from the implementation of the program sustainability action planning model and training curricula
Authors: Moreland-Russell Sarah , Jost Eliot , Gannon Jessica
Published: March 2023

Background

The emergence of implementation science has driven an increase in research examining the implementation of evidence-based programs and policies. However, there has been less attention through program sustainability. To achieve the full benefit of investment in program development and implementation, there must be an understanding of the factors that relate to sustainability; additionally, there is a need for a robust set of tools and trainings to support strategic long-term program sustainability. This paper presents results of our sustainability training intervention and a new conceptual model of sustainability. The proposed conceptual model builds upon the intervention design, further specifying the implementation strategy, strategy-mechanism linkages, and effect modifiers.

Methods

This research is part of the larger randomized control trial evaluating the effectiveness of the Program Sustainability Action Planning Model and Training Curricula. Specifically, this multimethod study establishes a conceptual model for program sustainability and related capacity-building interventions. The training intervention was delivered through workshops and technical assistance to 11 state tobacco control programs, principally entailing the development and implementation of a sustainability action plan. We utilize descriptive statistics and participant perspectives to evaluate the training intervention and propose an empirically-grounded conceptual model for sustainability capacity-building interventions in public health settings.

Results

Participants found intervention components (workshop, workbook, instructor and resources) to be effective. Overall, participants found the intervention improved their ability to develop sustainability action plans and assess their program and partners. Throughout the study, program managers emphasized the importance of the workshop in providing direction for their sustainability work and the value of robust, ongoing technical assistance. Program managers identified several factors that interfered with intervention reception including staff turnover, competing priorities, partnership challenges, and the COVID-19 pandemic.

Conclusion

The present study documents the development and implementation of a novel Program Sustainability Action Planning Model and Training Curricula, one of the first interventions designed to improve program sustainability. In addition, we present an empirically-grounded conceptual model for program sustainability. Considering the paucity of research in this understudied and undefined topic area, this is an important contribution that can serve as a framework for similar intervention designs and implementation efforts.

Clinical Trail Registration: ClinicalTrails.gov identification number is NCT03598114.
Collaborative survival in the city: Envisioning alternative urban futures through Black agrarian praxis
Authors: Lindemann Justine
Published: March 2023

Urban inhabitants exist within hybrid spaces of continual transformation and metabolism where human labor is woven into the work of the trees, the grass, the water cycle. The built environment – concrete, houses, skyscrapers – butts up against urban riparian zones and wetlands. The postindustrial landscape exposes both the possibilities and the limits of building resilience in the context of constant metabolism and change. This article asks about the potential for collaborative survival in these spaces of deindustrialization, where the abundance of so-called vacant parcels represent a pathway toward more self-determined food systems and the potential for reimagined urban futures. I play with the concept of collaborative survival to consider a plurality of epistemologies, knowledge systems, and traditions, as well as histories and geographies of exclusion that contribute to this reimagining. I examine the work of Black gardeners and farmers in Cleveland, OH as an example of collaborative survival: their work within a changing environment to grow food for themselves and their community, producing the city around them as a socio-ecological hybrid. Urban food production, in this case, serves as a praxis and a knowledge frame for liberation and emancipation. This paper explores urban agrarianism among Black residents in light of two historical moments that have deeply impacted Cleveland, and that I argue have shaped and informed Black agrarian praxis and growers' urban imaginaries. Collaborative survival recognizes that processes of urban development are ongoing and immanent and contests developmentalist narratives that marginalize epistemologies embracing alternative urban futures. Examining Black growers' experiences with attention to a framing around survival and resilience highlights the continuity of structural and systemic racism and violence against Black and brown bodies, as well as the innovations that individuals and groups deploy to contest that violence.