bluuebunny/crossref_metadata_2025 huggingface dataset:
Implementasi Kebijakan Layanan Bimbingan Psiko-Edukatif Dalam Membantu Tugas Perkembangan Peserta Didik Sekolah Dasar Di Kota Kediri
Authors: Anti Hanti
Published: April 2020

Abstrak: Tujuan penelitian ini untuk mengetahui implementasi kebijakan layanan bimbingan psiko-edukatif dalam membantu tugas perkembangan peserta didik SD di Kota Kediri dan untuk mengetahui faktor pendukung, faktor penghambat, serta upaya yang diterapkan dalam mengatasi hambatan dalam proses implementasinya. Penelitian ini merupakan penelitian deskriptif kualitatif sekolah dasar di kota Kediri, dengan teknik pengumpulan data berupa wawancara, observasi, dan dokumentasi. Hasil penelitian ini menunjukkan bahwa implementasi kebijakan layanan bimbingan psiko-edukatif dilaksanakan oleh guru kelas sebagai tugas tambahan yang diberikan oleh kepala sekolah. Hal tersebut didukung dengan guru kelas yang dinilai mampu mengondisikan kelas yang diampunya. Beberapa kendala yang dialami antara lain tidak adanya tenaga guru BK/konselor sekolah, pemberian layanan tidak terprogram dengan baik oleh guru kelas, pemerintah tidak menempatkan guru BK pada sekolah negeri dan bila mengadakan sendiri terkendala dengan dana, dan tidak adanya ruang konseling di sekolah. Sedangkan solusi yang diterapkan yaitu menempatkan guru senior sebagai guru kelas tinggi (kelas 4,5,6), mengadakan kerja sama dengan instansi yang terkait (KPAI, BNN, Kepolisian), dan kepala sekolah juga ikut terjun langsung membantu guru kelas dalam membantu menyelesaikan permasalahn peserta didik.Kata Kunci: Kebijakan, Layanan Bimbingan Psiko-Edukatif, Tugas PerlembanganAbstract: The purpose of this study was to determine the implementation of psycho-educational guidance service policies in assisting the task of developing elementary school students in the City of Kediri and to find out supporting factors, inhibiting factors, as well as the efforts implemented in overcoming obstacles in the implementation process. This research is a qualitative descriptive study of elementary schools in the city of Kediri, with data collection techniques in the form of interviews, observation, and documentation. The results of this study indicate that the implementation of the psycho-educational guidance service policy is carried out by the class teacher as an additional task given by the principal. This is supported by the class teacher who is considered able to condition the class he is in. Some constraints experienced include the absence of BK counselors/school counselors, the provision of services not well programmed by class teachers, the government does not place BK teachers in public schools and if it is self-constrained with funds, and there is no counseling room in schools. While the solution applied in placing senior teachers as high-class teachers (grades 4,5,6), collaborating with related institutions (KPAI, BNN, Police), and school principals also directly involved in helping class teachers in helping solve problems learners.Keywords: Policy, Psycho-Educational Guidance Services, Development Tasks
Chinese Initial Teaching Scheme Designed for Indonesian Beginners
Authors: Candra Haryono , Sukma Yusup Gumilar
Published: April 2020

As a part of the primary stage of Chinese phonetic teaching, the importance of Chinese initial teaching is self-evident, as initial pronunciation errors can affect the results of communication. Therefore, when Indonesian students begin to learn Chinese phonetics, they should first master the pronunciation characteristics of Chinese initials. This study has made a deeper exploration based on previous studies. This study aims to propose an initial teaching scheme for Indonesian beginners built on sorting out. Through comparison between the consonant systems in Chinese and Indonesian languages, analysis of the difficulties of Indonesian students' acquisition of Chinese initials, and investigation of the arrangement of initials in the “Scheme of the Chinese Phonetic Alphabet”, this study has designed a Chinese initial teaching scheme for Indonesian Chinese beginners with the purpose of improving the quality of Chinese initial teaching in Indonesia. Literature integration analysis and a qualitative research method were adopted in this study. By integrating existing literature and combining them with the authors’ own research findings, the design of the initial teaching scheme is optimized. The design features of this scheme are mainly reflected in the following aspects: first, arranging Chinese initials from easy to difficult to learn; second, strengthening the teaching and practice of Chinese initials which are different from Indonesian initials and simplifying those of Chinese initials which are identical to Indonesian initials; third, using the Indonesian alphabet or syllables as a guide to bring out Chinese initials. All of these can be regarded as the main results of this study and can be used as reference for further studies.
Review on Effects of NSAID`S on Different Systems
Authors: Puppala Naresh , Reddy Gantala Alekhya
Published: April 2020

Non steroidal anti-inflammatory drugs (NSAIDs) are amongst the most commonly prescribed medication. Some are available over the counter and likely to be abused. The gastrointestinal (GI), renal and cardiovascular (CV) side effects limit NSAIDs use. These side effects occurred at a rate as low as 1%–5% for NSAID users. The gastrointestinal (GI), renal and cardiovascular (CV) side effects limit NSAIDs use. Some studies  have shown  that an extra 2to8 per 1000 people per year may have a major vascular event from using an NSAID. Several studies demonstrated that conventional NSAIDs were associated with a higher risk of AKI and GN and decreased kidney hemodynamic functions, including sodium excretion. NSAIDs have a range of adverse effects mainly affecting the GI, renal and CV systems.
Evaluation of Pharmaceutical Care Standard Implementation in Medan City Health Center, North Sumatra
Authors: H Erviana N , W Wiryanto , U Harahap
Published: April 2020

Objectives: The implementation of Pharmaceutical Care Standards policies in health centers can be seen from the extent of suitability of human resources, facilities and infrastructure, management of medicines and consumable medical materials, clinical pharmacy care and quality control of pharmaceutical care. Inadequate implementation with the Pharmaceutical Care Standards policy will have a negative impact on service quality. This study aims to evaluate the implementation of Minister of Health Regulation No. 74 of 2016 concerning Pharmaceutical Care Standards in Medan City Health Center.Methods: This research is a cross sectional descriptive survey research. Data obtained from filling out questionnaire sheets and checklist sheets based on direct observation in outpatient health centers that have pharmacists and pharmacy technical staff at the pharmacy. The data obtained were analyzed using indicators and compared with literature standards. This research was conducted in July - October 2019.Results: The results showed that the total score of implementation of Pharmaceutical Care Standards in Medan City Health Center was 73-82 included in category II / moderate. Implementation has not yet fully met the standards, this is indicated by aspects of facilities and infrastructure; clinical pharmacy care have not been carried out effectively because it is related to the ratio between the number of patients with pharmacists and pharmaceutical technical personnel in the health center that is still not rational; and management of drugs and medical consumables. Assessment of the highest level of patient satisfaction is the Satisfaction category, as many as 77.89-97.87%.Conclusions: Implementation of Minister of Health Regulation No. 74 of 2016 concerning Pharmaceutical Care Standards in Medan City Health Center is included in the Medium Category. Factors affecting implementation include human resources and infrastructure. The level of patient satisfaction is Satisfied Category.
Formulation and In-Vitro Evaluation Curcumin Ovule with Polyethylene Glycol (Peg) Base
Authors: Delarosa Dathin Aulia , S Sumaiyah , Hasibuan Poppy Anjelisa Z.
Published: April 2020

Objective: This study aims to formulate and in vitro evaluation curcumin ovule with polyethylene glycol bases 400 and 6000 concentration variation using fushion method.

Method: Curcumin ovule formulated by fushion method using the comparison of polyethylene glycol 400 and 6000 base concentration. In vitro evaluation of preparations included observation of organoleptic (odor, color, and shape), measurement of uniformity of weight, disintegration time, observation of stability of the preparation during 6 months storage at refrigerator temperature, and release test.

Results: The results showed that all preparations ovule curcumin were orange, specific odor, cone-shape, stable for 6 months storage at refrigerator. Uniformity of ovule weight and disintegration time according the standard prepaation. Ovule release test showed formula I polyethylen glycol base concentration of 400 (90%) and 6000 (10%) very fast to release of curcumin from the preparation compared to other formula is gave average release of 93,7% ± SD 0.36.

Conclusion: Curcumin can be formulated in the form of ovule using polyethylene glycol bases 400 and 6000 concentration variation.
Evaluation esthetic and functional outcomes after rhinoplasty
Authors: Hawrami Falah Abdulla Hussein , Amin Zanyar M. , Mahmood Muhammad , Hama Rebwar A.
Published: April 2020

Objective: The aim of this study was to determine patient satisfaction in regard to nose appearance and function with the use of a validated questionnaire, before and after rhinoplasty surgery.

Methods: A prospective study was conducted of all adult patients that underwent open rhinoplasty including other nasal procedures like septoplasty or turbinoplasty between September 2018 and August 2019 in both public and private hospital (Sulaimani Surgical Teaching Hospital and Faruk Medical City).The Rhinoplasty Outcome Evaluation (ROE) questionnaire was used to study the patients' view.

Results: 100 patients participated in this study by completing the questionnaires and the follow-up period. The main reasons for rhinoplasty in our patients were: aesthetic 54% (n=54), functional 2 %( n=2), and a combination of both in 44% (n=44) patients The mean ROE score of all patients pre operation was 51.8 (males: 49.04, females 54.74.) and the mean score post operation was 75.22(males 75.64, females 74.81) at six months with no statistically significant gender differences p value=0.79 However, both genders showed a statistically significant improvement between the preoperative and postoperative scores (mean difference = 23.42, P<0.017).In the pre-operative stage, patients recorded worse score for anxious and insecure (p < 0.05). There were no difference for gender, age, cause or literacy level in the mean post-operative scores (p > 0.05).

Conclusions: We found that patients who consider themselves anxious before surgery were less satisfied with the result of the procedure. Additionally Rhinoplasty surgery significantly improved patient quality of life regarding nose shape and function.
Ensaio da Vida e Morte de um Porco Caipira: Abate e Manipulação
Authors: Trivilin Pereira Maria Isabel
Published: April 2020

Resumo: O presente ensaio fotográfico acontece no processo de manipulação de um porco de trezentos quilos, após o abate. Os procedimentos que envolvem desde o corte à extração da banha, do couro e à fabricação da linguiça, do chouriço e do codeguim são realizados por uma família de agricultores e trabalhadores do campo, junto a amigos e vizinhos e servem de sustento para cerca de dez pessoas deste círculo, além dos outros participantes do sistema de troca de alimentos. O cenário é de uma comunidade rural no município de Ubiratã, região centro ocidental paranaense, de aproximadamente cento e trinta famílias, chamada São João, em que os moradores ainda possuem criações domésticas para o próprio consumo. A autora, membro da família, os acompanhou durante os quase três dias na intenção de ilustrar, para além das palavras, um momento bastante importante no ciclo do ano para os moradores do local na obtenção e manipulação de alimento.Palavras-chave: Abate. Manipulação. Animal. Alimento   ESSAY OF THE LIFE AND DEATH OF A COUNTRY PIG: SLAUGHTER AND HANDLING  Abstract: This photographic essay takes place in the process of handling a three-hundred-pound pig after slaughter. Procedures that range from cutting to lard, leather and sausage, chorizo and cod-nut production are carried out by a family of farmers and field workers, along with friends and neighbors, and support about ten people. people in this circle, as well as other participants in the food exchange system. The scenario is of a rural community in the municipality of Ubiratã, central western region of Paraná, of approximately one hundred and thirty families, called São João, where residents still have domestic livestock for their own consumption. The author, a member of the family, accompanied them for almost three days in order to illustrate, in addition to the words, a very important moment in the cycle of the year for local residents in obtaining and handling food.Keywords: Slaughter. Handling. Animal. Food
Could PES Change the Agrarian Structure? a Lesson Learned of Citaman Village, Banten
Authors: Sarifuddin Andri , Adiwibowo Suryo , Mardiana Rina
Published: April 2020

This study aimed to analyze changes in the agrarian structure in Citaman Village, whether or not capitalists enters the formation of community land, after payment for Environmental Services (PES) mechanism is effective. This research relies on the constructivism paradigm, using qualitative method. The primary data was collected through in-depth interviews and focus groups discussion, with farmer groups, community leaders and related parties. Relevant secondary data was also collected. The results show that: First the PES program which has been running for more than 15 years, has not changed the agrarian structure significantly in Citaman Village. The agricultural land is still dominantly controlled and owned by Citaman Village residents. Second the changes that occurred as a PES program were found in the patterns of agricultural land use. Agricultural land that was originally used for upland rice cultivation or huma is now turned into an agroforestry area.
Analysis of the main parameters of crude oil pipeline transport
Authors: Tolmac Jasna , Prvulovic Slavica , Nedic Marija , Tolmac Dragisa
Published: April 2020

The paper presents results of experimental research and simulation of the main parameters of crude oil pipeline transport. In Serbia, 70 % of the produced oil belongs to a paraffin type, of which over 25 % has a high content of paraffin. High-content paraffin oil usually has a high pour point. The paraffin content in crude oil from Vojvodina, Serbia, is in the range 7.5 to 26 %, and the oil pour temperature varies from 18 to 36?C. The imported crude oil has a flow point max. 8?C. Homogenization, i.e. mixing of domestic and imported crude oil, improves the transport properties and decreases the pour point. After homogenization, the crude oil is pre-heated, and then transported by a pipeline to the refinery for further processing. Heating induces modification of crude oil physical properties, especially flow properties so to prevent wax formation within the oil pipeline. The aim of this paper was to determine operating parameters and flow characteristics for a particular oil pipeline (428 mm inner diameter, 91,000 m length) under real operating conditions. By heating in the range of 20 - 50?C, the viscosity of crude oil was reduced, approaching the viscosity of water. The pipeline is isolated (100 mm thick isolation) and buried into in the ground (1 m depth). It is found that the heat transfer coefficient has a dominant influence on the cooling rate of the oil in the pipeline. The heat transfer coefficient is mainly determined by the isolation thickness so that it was determined as 0.60 W m-2 K-1 for + 100 mm thickness, while it was 2.20 W m-2 K-1 for the non-isolated pipeline. Heat losses through the main pipeline ranged from 36 - 110 kJ m-1 h-1 (10 - 30 W m-1). The difference between the starting and the ending temperature of crude oil ranged from 10 to 12?C. Such a decrease of ?t = 10 oC and, consequently, the increase in viscosity induced a noti-ceable increase in the pressure drop and pump power by 3 to 4 %, at the maximum flowrate of 0.194 m3 s-1 (700 m3 h-1). The cooling rate during transportation under stationary thermal and hydraulic conditions is in the range 0.52 ? 0.5 oC h-1. In the case of domestic oil (Vojvodina, Serbia) transport, the downtime should not exceed 24 h, since stopping and cooling of the oil would result in formation of solid paraffin particles followed by oil gelation.
Metabolic Responses to 24-Hour Fasting and Mild Cold Exposure in Overweight Individuals Are Correlated and Accompanied by Changes in FGF21 Concentration
Authors: Hollstein Tim , Heinitz Sascha , Ando Takafumi , Rodzevik Theresa L. , Basolo Alessio , Walter Mary , Chang Douglas C. , Krakoff Jonathan , Piaggi Paolo
Published: April 2020

A greater decrease in 24-h energy expenditure (24 EE) during 24-h fasting defines a “thriftier” metabolic phenotype prone to weight gain during overfeeding and resistant to weight loss during caloric restriction. As the thermogenic response to mild cold exposure (COLD) may similarly characterize this human phenotype identified by acute fasting conditions, we analyzed changes in 24 EE and sleeping metabolic rate (SLEEP) in a whole-room indirect calorimeter during 24-h fasting at thermoneutrality (24°C) and during energy balance both at thermoneutrality (24°C) and mild cold (19°C) in 20 healthy volunteers (80% male; aged 36.6 ± 11.4 years; percentage body fat 34.8 ± 10.5%). Greater decrease in 24 EE during fasting (thriftier phenotype) was associated with less increase in 24 EE during COLD (i.e., less cold-induced thermogenesis). Greater decreases in plasma fibroblast growth factor 21 (FGF21) after 24-h fasting and after COLD were highly correlated and associated with greater decreases in SLEEP in both conditions. We conclude that the metabolic responses to short-term fasting and COLD are associated with and mediated by the liver-derived hormone FGF21. Thus, the 24 EE response to COLD further identifies the “thrifty” versus “spendthrift” phenotype, providing an additional setting to investigate the physiological mechanisms underlying the human metabolic phenotype and characterizing the individual susceptibility to weight change.
Иммуно-гистохимический анализ содержания коллагена-I и коллагена-III в тканях клапанов сердца при различных формах инфекционного эндокардита: роль фонового состояния или влияние инфекции?
Authors: Griaznov D.V. , Kovalev S.A. , ZHdanov A.I. , Voroncova Z.A. , Lavrenov A.L. , Pershin E.V. , Zolotareva S.N. , Kinshov A.N. , Nekrasova N.V.
Published: April 2020

Введение.Коллагеновые волокна I и III типов являются основным компонентом внеклеточного матрикса клапанного аппарата сердца. Цель исследования изучение влияния различных форм инфекционного эндокардита (ИЭ) на экспрессию этих белков в тканях сердечных клапанов человека. Материал и методы.Данные 60 хирургических пациентов с ИЭ сравнены с показателями 28 хирургических пациентов с неинфекционным поражением клапанов. Иммуногистохимическое исследованиетканей клапанов сердца проводили с использованием сывороток, содержащих антитела к коллагену-I (K-I) и коллагену-III (K-III). Содержание белка оценивали посредством обработки показателей оптической плотности окраски. Результаты.При сравнении общей группы с ИЭ и контрольной группы различий в содержании K-I не обнаружено, в то же время при ИЭ получен существенно более низкий уровень K-III. В подгруппе с острым ИЭ выявлено значимое снижение экспрессии как K-I, так и K-III. При подостром эндокардите отмечено повышение уровня K-I и снижение уровня K-III в сравнении с контрольной группой (p0,0001 во всех вышеуказанных сравнениях). Наименьший уровень как K-I, так и K-III отмечен в двух подгруппах контрольной группы: в препаратах с кальцинированным аортальным стенозом (КАС) (pK-I0,003 pK-III0,019), а также образцах трехстворчатых клапанов (ТК) (pK-I0,0001 pK-III0,0001). Низкий уровень содержания обоих белков имел место также при вторичном эндокардите на фоне КАС (pK-I0,0001 pK-III0,0001), уменьшение экспрессии K-III обнаружено в инфекционном поражении ТК (p0,0001). При пролапсе митрального клапана (ПМК) и при ИЭ на фоне ПМК имело место снижение уровня K-III (p0,04 и 0,024 соответственно). Выводы.Основным отличительным признаком ИЭ явилось снижение уровня K-III. На распределение K-I и K-III при ИЭ оказывают влияние: локализация клапанного поражения, фоновая патология сердца, форма, активность и стадия инфекционного процесса.
Technological Pedagogical Content Knowledge (TPACK) in Teaching 21st Century Skills in the 21st Century Classroom
Authors: Shafie Hidayu , Abd Majid Faizah , Ismail Izaham Shah
Published: April 2020

This conceptual paper explores the concept of technological pedagogical content knowledge (TPACK) in relation to the teaching of 21st-century skills with the purpose of establishing a relationship between them. Due to the advancement and development of industrial revolution and technology, the education scenario also changes towards 21st-century education, whereby more focus is given on the use of technology and 21st-century skills. The teachers’ roles change, and they are required to not only teach the core subject matters, but they also have to teach and train the students with 21st-century skills. However, not all teachers are well-trained on how to teach those skills to the students, especially when they also have to integrate technology in their teaching as well. Therefore, it is crucial to investigate whether the teachers understand and know how to teach 21st-century skills while integrating technology at the same time. Based on this needs, this paper will discuss the teachers’ knowledge, understanding and application of the TPACK framework by Koehler et al. (2006) and how will this framework affect their teaching of 21st-century skills in the classroom. The 21st-century skills framework suggested by the Malaysian Ministry of Education called the 4C1V (communication, collaboration, critical thinking, creative thinking and values and ethics) which is based on the P21 framework is included in the conceptual framework of this study, along with the TPACK framework. This study will attempt to establish a relationship between these two frameworks through a quantitative study, and the findings from this study would contribute to the knowledge on what aspects or skills that teachers will need to improve in order to teach the 21st-century skills to the students.

 

KEYWORDS: Pedagogical Content Knowledge (PCK), Technological Pedagogical Content Knowledge (TPACK), 21st Century Education, 21st Century Skills
Creating Short-term Classes on Unification in South Korean Universities
Authors: Lee Andrea Rakushin , Yoo Hak Soo , Bailey Daniel R
Published: April 2020

Young adults will be the next generation of leaders, and it is critical for them to be cognizant of major issues that impact society. Unification is a significant issue in South Korea, especially in light of the recent summits between South and North Korea. This study is rooted in principles of peace education to promote peaceful discourse related to unification issues. Unification education plays an important role in K-12 education in South Korea; however, it is not prioritized at the university level. This case study, which included open-ended surveys, interviews, and focus groups, explored South Korean university students’ (n=33) views of creating short-term classes on unification and the types of topics that they think should be taught in these classes. Primary results indicate that most participants expressed interest in taking short-term classes on unification issues. The paper also includes practical implications that can be considered when developing short-term classes on unification in South Korean universities.
Unfolding of Filipino School Leadership Experiences in Doha, Qatar
Authors: Del Rosario Kris Anne , Ancho Inero
Published: April 2020

Due to internationalization, Qatar is hiring foreign educators and leaders to share expertise in their country. Filipinos are mostly hired as domestic helpers, yet there are also Filipino leaders in educational institutions that exist, particularly in the capital city Doha. The researchers find it significant to examine the experiences of Filipino teachers abroad, due to the rising number of educators and school leaders in Qatar. Romanowski et al. (2018) cited that there is a very few studies regarding principalship and diversity of educators notwithstanding the enormous knowledge of research that emphasize leadership in school and diversity of students. The study attempts to unfold the lived experiences of Filipino school managers in international schools in Doha, Qatar specifically with:  1) the experiences of Filipino school managers in terms of:  (a) Planning; (b) Organizing; (c) Leading and (d) Controlling.   2) The challenges of being a school leader in international schools in Doha. Four (4) themes emerged from the study with subthemes that depicted the experiences and challenges of Filipino school leaders.  Theme 1 explains the Filipino school leaders in complying with mandates and policies.  Theme 2 discusses the Filipino school leaders in adapting with culture.  Theme 3 defines the Filipino school leaders conforming with programs.  Theme 4 depicts the Filipino school leaders in conforming with resources. The study is beneficial to the aspiring and current school leaders not only to Filipinos, but also to other nationalities interested in or are presently managing international schools in Doha.

KEYWORDS: school leadership, school management, Filipino principals, experiences, culture
CLINIC AND PSYCHOANALYTIC PRACTICE WITH PUBESCENTS AND ADOLESCENTS
Authors: ARYAN Asbed
Published: April 2020

This is the last article written during the authaor's lifetime. In this article the author is discussing the problems of clinic and psychoanalytic practice.
ROLE AND VALUE OF COMMUNICATIVE COMPETENCE OF FUTURE MILITARY PSYCHOLOGIST DURING PROFESSIONAL DEVELOPMENT
Authors: PETROSYAN Ruzanna , MAKICHYAN Sona , ARAMYAN Lida
Published: April 2020

The psychological problem of the formation of communication competence of a military psychologist is conditioned by the unity of the problems faced by our army and the educational programs. It focuses on the process of formation and development of communication skills of the future military psychologist in the field of professional communication, in which the emphasis is on the direction of the future specialist in communication. Based on the results of the research, it is proposed to ensure the principle of uniformity of joint activities in the curricula and the introduction of training and innovation methods for communicative competence formation.
„Najnowsze osiągnięcia w okulistyce” – nowy podręcznik na rynku wydawniczym
Authors: Rejdak Robert
Published: April 2020

Recenzja książki: Grzybowski A (ed). Current Concepts in Ophthalmology. Springer International Publishing, 2020: 302. ISBN 978-3-030-25388-2.
Radiographic localization of the attachments of soft tissue structures in the tarsal region of horses
Authors: Casillas Jose M. , Jacobs Carrie C. , Manfredi Jane M.
Published: April 2020

OBJECTIVE

To identify radiographic locations of soft tissue attachments in the tarsal region of horses and describe any variability in the gross anatomy of those attachments.

SAMPLE

15 cadaveric limbs from 8 adult horses.

PROCEDURES

8 limbs were used for dissection and radiography of soft tissue structures, with metallic markers used to identify radiographic locations of soft tissue attachments. The remaining 7 limbs were used to evaluate anatomic variations in the insertion of the tendon of the fibularis tertius muscle. A consensus list of preferred radiographic views for evaluating each soft tissue attachment was created.

RESULTS

The dorsoplantar, dorsoproximolateral-plantarodistomedial oblique (35° proximal and 45° lateral), dorsoproximomedial-plantarodistolateral oblique (10° proximal and 15° medial), and plantaroproximal-plantarodistal oblique (70° proximal; flexed) views were preferred for evaluating the collateral ligaments. The standard oblique views and plantaroproximal-plantarodistal oblique (70° proximal; flexed) view were preferred for evaluating the tendinous attachments of the gastrocnemius and superficial digital flexor muscles. All 4 standard views were necessary for evaluating the tendinous attachments of the cranial tibial and fibularis tertius muscles, the dorsal tarsal ligament, and the origin of the suspensory ligament. Three configurations of the insertion of the fibularis tertius tendon were identified grossly. In limbs with osteoarthritis of the distal tarsal joints, the dorsal tarsal ligament firmly adhered to the centrodistal tarsal joint.

CONCLUSIONS AND CLINICAL RELEVANCE

Results indicated that attachments of soft tissue structures in the tarsal region of horses were in distinct radiographically identifiable locations and that visualization of individual soft tissue attachments could be optimized with certain radiographic views, including some nonstandard views.
Effectiveness of MB-102, a novel fluorescent tracer agent, for conducting ocular angiography in dogs
Authors: Pirie Christopher G. , Rogers Thomas E. , Dorshow Richard B.
Published: April 2020

OBJECTIVE

To evaluate the effectiveness of a novel fluorescence tracer agent, MB-102, for conducting ocular angiography in dogs.

ANIMALS

10 ophthalmologically normal dogs (2 to 4 years old) and 10 dogs with retinal degeneration or primary open-angle glaucoma (< 6 years old).

PROCEDURES

While anesthetized, all dogs received sodium fluorescein (20 mg/kg, IV) or MB-102 (20 or 40 mg/kg, IV) first and then the other dye in a second treatment session 2 days later in a randomized crossover design. Anterior fluorescence angiography was performed on one eye and posterior fluorescence angiography on the other. Imaging was performed with a full-spectrum camera and camera adaptor system. Filter sets that were tailored to match the excitation and emission characteristics of each angiographic fluorescent agent were used.

RESULTS

All phases and phase intervals during anterior and posterior segment angiography were identified, regardless of the dye used. However, agent fluorescence and visualization of the iridal blood vessels were hindered in some dogs, irrespective of agent, owing to the degree of iridal pigmentation present. No significant difference was noted between the 2 dyes in any phase or phase interval, and slight improvement in image contrast was observed with MB-102 during the venous phases owing to a reduction of vessel wall staining in both normal and diseased eyes.

CONCLUSIONS AND CLINICAL RELEVANCE

Results suggested that MB-102 would be useful for conducting ocular angiography in dogs.
Randomized controlled trial to evaluate a novel two-catheter technique for urethral catheterization in anesthetized healthy female cats and small dogs
Authors: Abrams Brittany E. , Selmic Laura E. , Howard James , Horvath Stephen J. , Bednarski Linda , McLoughlin Mary A. , Wavreille Vincent A.
Published: April 2020

OBJECTIVE

To evaluate a novel 2-catheter technique for urethral catheterization in female cats and small dogs and compare the time required for and success rates achieved by use of the novel technique versus traditional methods (blind technique in cats and digital palpation in dogs) as performed by personnel (catheter placers [CPs]) with different levels of experience in urinary catheter placement.

ANIMALS

39 healthy sexually intact female animals (24 cats and 15 dogs weighing < 10 kg).

PROCEDURES

2 CPs were board certified in veterinary surgery, 1 of whom had experience with the novel technique, and the other did not. The third CP was a veterinary surgical intern who was unfamiliar with the novel technique. For each animal enrolled in the study, 1 CP performed catheterization with the novel technique and traditional methods. Data recorded included the time required for successful catheterization and whether a successful catheterization was achieved within a 3-minute time limit.

RESULTS

The overall success rates were 79.5% (31/39 animals) with the novel technique and 43.6% (17/39 animals) with traditional methods. Median times for successful catheter placement were 48 seconds for the novel technique and 41 seconds for traditional methods. Among CPs, success rates or times to successful catheter placement did not differ significantly.

CONCLUSIONS AND CLINICAL RELEVANCE

Study results suggested that the novel 2-catheter technique for urethral catheterization may be a more efficient option than traditional methods for gaining access to the urinary bladder in cats and small dogs, particularly when patient size limits use of instrumentation or digital palpation.
The effect of Calcitriol 1,25 (OH)2 - D3 on osteoblast-like cell proliferation during in vitro cultivation
Authors: KATİCA Muhamed , TEPEKOY Filiz
Published: April 2020

Derived from mesenchymal stem cells (MSCs) under the influence of various local factors and growth hormones, osteoblasts are one of the leading components of the bone tissue. 1,25-dihydroxyvitamin D3 (calcitriol), an active form of vitamin D, plays an important role in retaining calcium and phosphate homeostasis within the body. Since vitamin D is also known to have effects on cell proliferation, our study aimed to investigate the effects of different concentrations of calcitriol on the proliferation of in vitro cultured osteoblast-like cells from the bone marrow of 90-95 days old young adult rats of both sexes. Calcitriol was applied at six (6) different concentrations (nM): 0.1, 1, 10, 20, 40 i 60. Each concentration was tested four times, counting the cells after 24 and 48 hours. After 24 and 48 hours treatment, the most effective dose of calcitriol for cell proliferation was 0.1 nM for both males and females. The greatest reduction in the frequency of OB-like cells from both sexes after treatment of 24 and 48 hours, was a 60 nM calcitriol concentration. Higher proliferative values of osteoblast-like cells were obtained in males compared to those obtained in females. Thus, the results of the current study reveal that calcitriol treatment induces the proliferation of osteoblast-like cells in a dose-dependent manner and this effect shows difference in cells from different genders.
On the sensibility of the Pairs Trading strategy: the case of the FTS stock market index
Authors: Fernández-Pérez Ainhoa , López-García María de las Nieves , Ramos Requena José Pedro
Published: April 2020

In this paper we present a non-conventional statistical arbitrage technique based in varying the number of standard deviations used to carry the trading strategy. We will show how values of 1 and 1,2 in the standard deviation provide better results that the classic strategy of Gatev et al (2006). An empirical application is performance using data of the FST100 index during the period 2010 to June 2019.
Institutionalization of statistical science in universities of the Russian Empire (late XVIII – early XIX centuries)
Authors: Skrydlov Andrei
Published: April 2020

The object of this research is the process of institutionalization of statistical science in Russia in the early XIX century. The article examines the history of emergence within the structure of Russian universities of the corresponding departments and inclusion of statistical knowledge into lectures. The author analyzes the peculiarities of teaching statistical science in the Moscow, Kharkov, Kazan, and Saint Petersburg universities. Special attention is given to the activity of M. l. Magnitsky and D. P. Runich, which led to termination of the reputable scholars-statisticians from Kazan and Saint Petersburg universities. The research leans on the basic methods of historical science – problem-chronological for studying the time sequence of events; historical-genetic and historical comparative that allow studying the genesis and key stages of development of statistical education in the Russian universities. It is established that teaching statistics in form of political science initially appeared in the last third of the XVIII century in the Moscow University. Statistical courses were read upon personal initiative of the professors and were not established by the provisional “Project” of 1755. In their lectures, the first educators were guided by the experience of Göttingen University, which in the mid XVIII century became the center of the German school of political science. The university reform of 1802-1804 in Russia led to the creation of new system of higher education. In accordance with the norms of the Decrees of 1804, statistics was introduced into the curriculum of Russian universities for the first time. The article explores the key stages of organization of teaching statistics, such as unification of the content of lectures, publishing of course books, establishment of scientific schools.
The image of Greenland in Icelandic Saga tradition: to the question on formation of binary image of Home and Anti-Home
Authors: Nosova Ekaterina Sergeevna
Published: April 2020

Currently, the national humanities science shows particular interest in the phenomena that have been previously outside its area of expertise. These phenomena include materialistic objects, which in the context of cultural-semiotic approach turn into meaningful constants. One of such materialistic-spiritual phenomena is the concept of “home”. For Icelanders, during the period of civil war marked in history as the Age of the Sturlungs, the phenomenon of “home” undergoes substantial transformation. Forced exile from the country, loss of relationship with family, and building a new life contribute to conception and formation of the new semantic space structured on the binary image: Home – Anti-Home. Within the Icelandic Saga tradition, the image of negative home belongs of the island of Greenland, which provided an temporary shelter and reflected the overall atmosphere of forced migrants. The article is dedicated to the examination of the image of Greenland in Icelandic Saga tradition. The author reveals the key parameters of formation of the image of Greenland as an “alien” space, formed among the Icelanders who were forced to leave their country. This leads to the emergence of antithesis in Saga literature: home and homelessness. The concept of “home” is associate with Iceland and saturated with additional shades of meaning, turning into and object of reminiscence and becoming the embodiment of spiritual substance. Greenland, on the contrary, was endowed with the traits of hostile space with regards to a person.
Pre- and post-treatment levels of serum high-sensitivity C-reactive protein in patients with lesions of endodontic origin: A clinical pilot study
Authors: Bains Rhythm , Tikku Aseem P. , Ali Wahid , Verma Promila , Pandey Pragya
Published: April 2020

Objective:

The objective of the study was to evaluate the impact of lesions of endodontic origin (LEO) and their treatment on the patients’ serum high-sensitivity C-reactive protein (hs-CRP) levels.

Materials and Methods:

A total of 20 healthy patients with radiographic evidence of LEO in at least one tooth were recruited for the study, of which 11 were finally evaluated. Before initiating the endodontic treatment, 10 ml of patient’s venous was taken from the antecubital vein to assess the pre-operative serum hs-CRP levels (T0). Canals were prepared with K-files till a suitable size and irrigated with 2.5% sodium hypochlorite. At the subsequent appointment after 1 week, teeth were obturated. The patients were then recalled 30 days after the completion of endodontic therapy. Again blood samples will be taken at time-frame T1 to assess the serum hs- CRP levels. The change in pre- and post-treatment values for T0 and T1 was statistically evaluated to assess the effect of treatment on serum hs-CRP levels.

Results:

The mean CRP (mg/L) at T0 ± SD (Range) at baseline was 6.18 ± 3.72 (0.96–11.02) and the mean CRP at T1 ± SD (Range) was 3.92 ± 3.59 (1.108–11.04) and mean change in CRP ± SD (Range) after 30 days follow-up was −2.26 ± 3.04 (−8.26–1.16). Significance of change in CRP levels (Paired t-test) was t = 2.458; P = 0.034.

Conclusion:

The results of the present study indicate that root canal treatment reduced the levels of hs-CRP in the serum of the patients having LEO. Timely diagnosis and treatment of these lesions may have some contribution in reducing systemic inflammatory burden.
Analisis Tingkat Implementasi Good Corporate Governance Pada Usaha Kecil Dan Menengah (UKM) di Kota Padang
Authors: Aisyah Hesty
Published: April 2020

Nowadays economic independence is one indicator in measuring the welfare of a country. Economic independence is made from the current country's economic system. An economic system is a systematic way in which a country distributes its resources. The better the system is implemented, the better the economic growth rate of the country will be. One things that mostly affect the rate of economic growth is the increasing number of Small and Medium Enterprises (SMEs). Therefore, the government has designed the program for SMEs which is not supported by Good Corporate Governance (GCG), which results in lack of integrations between the government program and the SME management system. The purpose of this study is to investigate aspects of the management arrangements of 150 SMEs in Padang, and also to identified all aspects which is need to be modified so that the Good Corporate Governance (GCG) system can be implemented on these SMEs. The survey results in this study found that the implementation of Good Corporate Governance in Padang City SMEs is still very limited, so this research still needs to be explored further to find the right Good Corporate Governance (GCG) patterns implemented for Padang’s SMEs.
Not One, But Five: Virtual Screening-Driven Drug Discovery of SARS-CoV2 Enzyme Inhibitors Targeting Viral Attachment, Replication and Post-Translational Infection Mechanisms
Authors: Quimque Mark Tristan J. , Notarte Kin Israel , Fernandez Rey Arturo T. , Mendoza Mark Andrew O. , Liman Rhenz Alfred D. , Lim Justin Allen K. , Pilapil Luis Agustin E. , Ong Jehiel Karsten H. , Pastrana Adriel M. , Macabeo Allan Patrick
Published: April 2020

The novel coronavirus SARS-CoV2, the causative agent of the worldwide pandemic disease COVID-19, emerged in December 2019 forcing lockdown of communities in many countries. The absence of specific drugs and vaccines, the rapid transmission of the virus, and the increasing number of deaths worldwide have necessitated the need to discover substances that can be tapped for drug development. With the aid of bioinformatics and computational modelling, ninety seven secondary metabolites from fungi previously reported to exhibit antiviral properties were docked onto SARS-CoV2 enzymes involved in viral attachment, replication and post-translational mechanisms followed by in silico ADMET prediction (absorption, distribution, metabolism, excretion and toxicity) of the hit compounds. Thus, two fumiquinazoline alkaloids quinadoline B (19), scedapin C (15), and the polyketide isochaetochromin D1 (8) exhibited high binding affinities depending on the target protein. The compounds were active against the cysteine proteases, papain-like protease (PLpro) and chymotrypsin-like protease (3CLpro) which are involved in post-translational modifications, RNA-directed RNA polymerase (RdRp) which is essential in viral replication, non-structural protein 15 (nsp15) which is involved in evasion of host immunity, and the spike protein which is responsible for binding to GRP78. Quinadoline B (19) was predicted to confer favorable ADMET values, high gastrointestinal absorptive probability and poor blood-brain barrier crossing capacities.
Enantiomeric Excess Dependent Splitting of NMR Signal Through Co-Ligand Dynamic Exchange in a Coordination Complex
Authors: Takimoto Kazuyoshi , Ishihara Shinsuke , Labuta Jan , Březina Václav , Payne Daniel , Ariga Katsuhiko , Hill Jonathan P. , Sumita Masato , Mori Shigeki , Sato Hisako
Published: April 2020

A coordination complex (L·2Zn·3C), where L is a prochiral ligand and C is an exchangeable acetate co-ligand, exhibits symmetrical splitting of 1H-NMR resonances due to L, which is proportional to the enantiomeric excess (ee) of a chiral guest co-ligand, 2-phenoxypropionic acid (PPA). The NMR resonances remain split even in dilute solution due to the high stability of complex with chiral guest.
In Silico Identification of a Potent Arsenic Based Approved Drug Darinaparsin against SARS-CoV-2: Inhibitor of RNA dependent RNA polymerase (RdRp) and Necessary Proteases
Authors: Chowdhury Trinath , Roymahapatra Gourisankar , Mandal Santi M
Published: April 2020

The work demonstrate screening of several arsenical compounds against RdRp of coronavirus. The study implies out of all arsenical compounds, darinaparsin shows its most effective results based on in silico docking analysis. This study also confirmed the significant interaction between the active site of viral replicase protein, endoribonuclease protein and different proteases with darinaparsin.
Effects of Single α-to-β Residue Replacements on Recognition of an Extended Segment in a Viral Fusion Protein
Authors: Outlaw Victor , Kreitler Dale F. , Stelitano Debora , Porotto Matteo , Moscona Anne , Gellman Samuel H.
Published: April 2020

Partial replacement of α-amino acid residues with β-amino acid residues has been established as a strategy for preserving target-engagement by helix-forming polypeptides while suppressing susceptibility to proteolysis. The impact of β-residue incorporation within polypeptides that adopt less regular conformations, however, has received less attention. The HRC domains of fusion glycoproteins from pathogenic paramyxoviruses contain a segment that must adopt an extended conformation in order to engage the HRN domain in the post-fusion state and drive merger of the viral envelope with a target cell membrane. Here we examine the impact of single α-to-β substi-tutions within this extended N-terminal segment of the engineered HRC peptide VIQKI. Stabilities of helix-bundles formed with a native viral HRN have been evaluated, the structures of five helix-bundles have been determined, and antiviral efficacies have been measured. Many sites within the extended segment show functional tolerance of α-to-β substitution. These results offer a basis for future develop-ment of protease-resistant inhibitors of paramyxovirus infection.