bluuebunny/crossref_metadata_2025 huggingface dataset:
Synthesis of 2,6‐Dimethyl‐9‐aryl‐9‐phosphabicyclo[3.3.1]nonanes: Their Application to Asymmetric Synthesis of Chiral Tetrahydroquinolines and Relatives.
Authors: Hara Osamu , Koshizawa Tomoaki , Makino Kazuishi , Kunimune Iyo , Namiki Atsushi , Hamada Yasumasa
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Novel Three‐Component Reaction for the Synthesis of New 4‐Azafluorenone Derivatives.
Authors: Tu Shujiang , Jiang Bo , Jiang Hong , Zhang Yan , Jia Runhong , Zhang Junyong , Shao Qingqing , Li Chunmei , Zhou Dianxiang , Cao Longji
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
1,2,3,4‐Tetrahydro‐1,5‐naphthyridines and Related Heterocyclic Scaffolds: Exploration of Suitable Chemistry for Library Development.
Authors: Woo Grace H. C. , Beeler Aaron B. , Snyder John K.
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A General Synthetic Route to Enantiopure cis‐Fused Perhydrocycloalka[c]pyridines from Phenylglycinol‐Derived Lactams.
Authors: Amat Mercedes , Perez Maria , Minaglia Annamaria T. , Peretto Bruno , Bosch Joan
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Efficient Synthesis of Pyrimidinecarbonitriles and Their Derivatives.
Authors: Dolakova Petra , Masojidkova Milena , Holy Antonio
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Microwave‐Assisted Synthesis of mGluR1 Ligands: Carbon, Nitrogen and Oxygen Linked Derivatives of Pyrido[3,4‐d]pyrimidin‐4‐ylamines.
Authors: Harbottle Gareth W. , Feeder Neil , Gibson Karl R. , Glossop Mel , Maw Graham N. , Million William A. , Morel Florence F. , Osborne Simon , Poinsard Cedric
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis and Antibacterial Activity of Some Novel Triazolothienopyrimidines.
Authors: Prasad Mailavaram Raghu , Prashanth John , Shilpa Kalghatgi , Kishore Deb Pran
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Domino Oxidation—Michael Reactions of Catechols with Barbituric Acid Derivatives in Water: An Efficient Synthesis of Polycyclic Pyrimidinones.
Authors: Alizadeh Abdolhamid , Nematollahi Davood , Hbibi Davood , Hesari Mahdi
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Preparation of a 1‐Unsubstituted‐2,3‐dihydro‐1‐benzazepine Derivative.
Authors: Nishiguchi Atsuko , Ikemoto Tomomi , Ito Tatsuya , Miura Shotaro , Tomimatsu Kiminori
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of Conformationally Constrained α‐Imino Acid Derivatives via Ring‐Closing Metathesis.
Authors: Kotha Sambasivarao , Khedkar Priti
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Novel Approach to 12‐Chloro‐3‐thio‐4H‐quino[3,2‐e][1,3]diazocines via Vilsmeier—Haack Reaction
Authors: Kumar R. Nandha , Suresh T. , Dhanabal T. , Mohan P. S.
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
General Access to a Novel Class of Silyl Heterocycles.
Authors: Degl'Innocenti A. , Capperucci A. , Malesci I. , Acciai M. , Castagnoli G.
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Organocatalytic Asymmetric Hydrophosphination of α,β‐Unsaturated Aldehydes.
Authors: Carlone Armando , Bartoli Giuseppe , Bosco Marcella , Sambri Letizia , Melchiorre Paolo
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Enantioselective Organocatalytic Hydrophosphination of α,β‐Unsaturated Aldehydes.
Authors: Ibrahem Ismail , Rios Ramon , Vesely Jan , Hammar Peter , Eriksson Lars , Himo Fahmi , Cordova Armando
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Enantioselective Synthesis of α‐Aminopropargylphosphonates.
Authors: Dodda Rajasekhar , Zhao Cong‐Gui
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
4‐Methyl‐1,2,3‐selenadiazole‐5‐carboxylic Acid Amides: Antitumor Action and Cytotoxic Effect Correlation.
Authors: Arsenyan Pavel , Rubina Kira , Shestakova Irina , Domracheva Ilona
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Guaianolide Sulfate Conjugate and Other Constituents from Taraxacum alpinum
Authors: Michalska K. , Kisiel W.
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Strobilols A—D: Four Cadinane‐Type Sesquiterpenes from the Edible Mushroom Strobilurus ohshimae.
Authors: Hiramatsu Fuminori , Murayama Tetsuya , Koseki Takuya , Shiono Yoshihito
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Unusual KMnO4 Oxidation Product of β‐Ionone.
Authors: Kamat Shrivallabh P. , D'Souza Asha M. , Paknikar Shashikumar K. , Bhadbhade Mohan M. , Gonnade Rajesh G.
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Efficient Synthesis of (.+‐.)‐N‐Boc‐pregabalin (VI) via Hetero‐Diels—Alder Addition of Methyl 3‐Nitrosoacrylate to Ethyl Vinyl Ether.
Authors: Gallos John K. , Alexandraki Elli S. , Stathakis Christos I.
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Stereoselective Syntheses and Reactions of Stannylated Peptides.
Authors: Deska Jan , Kazmaier Uli
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
De Novo Asymmetric Synthesis of the Anthrax Tetrasaccharide by a Palladium‐Catalyzed Glycosylation Reaction.
Authors: Guo Haibing , O'Doherty George A.
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Studies Directed to the Synthesis of Oligochitosans — Preparation of Building Blocks and Their Evaluation in Glycosylation Studies.
Authors: Hansen Signe Grann , Skrydstrup Troels
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Short Synthesis of (+)‐Cylindricine C and Formal Total Synthesis of (‐)‐Lepadiformine.
Authors: Mihara Hisashi , Shibuguchi Tomoyuki , Kuramochi Akiyoshi , Ohshima Takashi , Shibasaki Masakatsu
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Soraphinol A, a New Indole Alkaloid from Sorangium cellulosum.
Authors: Li XueMei , Zee Ok Pyo , Shin Hee Jae , Seo Youngwan , Ahn Jong‐Woong
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of 6β‐D‐Glucosyl and 6‐Nitroxy (‐)‐Galanthamine Derivatives as Acetylcholinesterase Inhibitors.
Authors: Perissutti E. , Fiorino F. , Severino B. , Frecentese F. , Massarelli P. , Nencini C. , Santagada V. , Caliendo G.
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Towards a Biomimetic Synthesis of Barrenazine A.
Authors: Buron Frederic , Turck Alain , Ple Nelly , Bischoff Laurent , Marsais Francis
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Novel Simple Efficient Synthetic Approach Toward 6‐Substituted‐2H‐[1,2,4]triazolo[3,4‐b][1,3,4]thiadiazole‐3‐thiones and First Synthesis and Biological Evaluation of N‐ and S‐β‐D‐Glucosides of the [1,2,4]Triazolo[3,4‐b][1,3,4]thiadiazole Ring System.
Authors: Khalil Nasser S. A. M.
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Short Synthesis and Antiviral Evaluation of C‐Fluoro‐Branched Cyclopropyl Nucleosides.
Authors: Oh Chang Hyun , Hong Joon Hee
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Delivery of Antisense Oligonucleotides to Nuclear Telomere RNA by Use of a Complex Between Polysaccharide and Polynucleotide.
Authors: Sakurai Kazuo , et al. et al.
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Sinaicinone, a Complex Adamantanyl Derivative from Hypericum sinaicum.
Authors: Rezanka Tomas , Sigler Karel
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Cyathenosin A, a Spiropyranosyl Derivative of Protocatechuic Acid from Cyathea phalerata.
Authors: Pizzolatti Moacir Geraldo , Brighente Ines Maria Costa , Bortoluzzi Adailton Joao , Schripsema Jan , Verdi Luiz Gonzaga
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
The Structure of Maitotoxin.
Authors: Nicolaou K. C. , Frederick Michael O.
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Total Synthesis of (‐)‐Ulapualide A (I): The Danger of Overdependence on NMR Spectroscopy in Assignment of Stereochemistry.
Authors: Pattenden Gerald , Ashweek Neil J. , Baker‐Glenn Charles A. G. , Walker Gary M. , Yee James G. K.
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Database of Historically‐Observed Chemical Replacements.
Authors: Haubertin David Y. , Bruneau Pierre
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Understanding False Positives in Reporter Gene Assays: In silico Chemogenomics Approaches to Prioritize Cell‐Based HTS Data.
Authors: Glick Meir , et al. et al.
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Library Fingerprints: A Novel Approach to the Screening of Virtual Libraries.
Authors: Klon Anthony E. , Diller David J.
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Exploring Peptide‐Likeness of Active Molecules Using 2D Fingerprint Methods.
Authors: Eckert Hanna , Bajorath Juergen
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Automatic Perception of Organic Molecules Based on Essential Structural Information.
Authors: Zhao Yuan , Cheng Tiejun , Wang Renxiao
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Large‐Scale Annotation of Small‐Molecule Libraries Using Public Databases.
Authors: Zhou Yingyao , Zhou Bin , Chen Kaisheng , Yan S. Frank , King Frederick J. , Jiang Shumei , Winzeler Elizabeth A.
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Pose Prediction Accuracy in Docking Studies and Enrichment of Activies in the Active Site of GSK‐3β.
Authors: Gadakar Pravin Kumar , Phukan Samiron , Dattatreya Prasanna , Balaji V. N.
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Modeling Robust QSAR 3: SOM‐4D‐QSAR with Iterative Variable Elimination IVE‐PLS: Application to Steroid, Azo Dye, and Benzoic Acid Series.
Authors: Bak Andrzej , Polanski Jaroslaw
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Lennard‐Jones Potential and Dummy Atom Settings to Overcome the AUTODOCK Limitation in Treating Flexible Ring Systems.
Authors: Forli Stefano , Botta Maurizio
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Mechanism of the Kolbe—Schmitt Reaction. Structure of the Intermediate Potassium Phenoxide—CO2 Complex.
Authors: Markovic Zoran , Markovic Svetlana , Manojlovic Nedeljko , Predojevic‐Simovic Jasmina
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Production of Fine Tantalum Powder by Preform Reduction Process Using Mg—Ag Alloy Reductant.
Authors: Yuan Boyan , Okabe Toru H.
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis and Antimicrobial Activity of Some Novel Furyl and Benzimidazole Substituted Benzyl Ethers.
Authors: Gueven Oezden Oezel , Erdogan Taner , Goeker Hakan , Yildiz Sulhiye
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis and Antimalarial Activity of 7‐Benzylamino‐1‐isoquinolinamines.
Authors: Gutteridge Clare E. , Hoffman Marshall M. , Bhattacharjee Apurba K. , Gerena Lucia
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Hydrogen Production in Solid Electrolyte Membrane Reactors (SEMRs)
Authors: Athanassiou C. , Pekridis G. , Kaklidis N. , Kalimeri K. , Vartzoka S. , Marnellos G.
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
IV‐VI Ferromagnetic Semiconductors — Recent Studies
Authors: Dobrowolski W. , Arciszewska M. , Brodowska B. , Domukhovski V. , Dugaev V. K. , Grzeda A. , Kuryliszyn‐Kudelska I. , Wojcik M. , Slynko E. I.
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Evidence of Active Species in CO Oxidation Catalyzed by Highly Dispersed Supported Gold
Authors: Fierro‐Gonzalez Juan C. , Gates Bruce C.
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
The Effect of Nonequilibrium Excitation on the Ignition of Hydrogen—Oxygen Mixtures
Authors: Popov N. A.
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Polyferrocenylsilane‐Based Polymer Systems
Authors: Bellas Vasilios , Rehahn Matthias
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Recent Advances in the Formation of Luminescent Lanthanide Architectures and Self‐Assemblies from Structurally Defined Ligands
Authors: Gunnlaugsson Thorfinnur , Stomeo Floriana
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Silica‐Supported Pd Catalysts for Heck Coupling Reactions
Authors: Polshettiwar Vivek , Molnar Arpad
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Recent Advances in Practice and Theory of Polyfluoroarene Hydrodehalogenation
Authors: Shteingarts Vitalij D.
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Electron Transfer in Organonickel Complexes of α‐Diimines: Versatile Redox Catalysts for C—C or C—P Coupling Reactions — A Review
Authors: Klein Axel , Budnikova Yulia H. , Sinyashin Oleg G.
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Bringing Efficiency to Materials Synthesis: The Philosophy of Click Chemistry
Authors: Hawker Craig J. , Fokin Valery V. , Finn M. G. , Sharpless K. Barry
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
The Rise of Azide—Alkyne 1,3‐Dipolar “Click” Cycloaddition and Its Application to Polymer Science and Surface Modification
Authors: Evans Richard A.
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Fundamentals and Applications of Soluble Carbon Nanotubes
Authors: Nakashima Naotoshi , Fujigaya Tsuyohiko
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Hydrates and Solid‐State Reactivity: β‐Lactam Antibiotics
Authors: Hickey Magali B. , Peterson Matthew L. , Manas Eric S. , Alvarez Juan , Haeffner Fredrik , Almarsson Orn
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of Cystine‐Rich Peptides
Authors: Boulegue Cyril , Musiol Hans‐Juergen , Prasad Vidya , Moroder Luis
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
High Throughput Synthesis of Peptides and Peptidomimetics
Authors: Hruby Victor J. , Vagner Josef
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of Guanidines in Solution
Authors: Suhs T. , Koenig B.
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Chemical Synthesis and Biosynthesis of the Cyclotide Family of Circular Proteins
Authors: Gunasekera Sunithi , Daly Norelle L. , Anderson Marilyn A. , Craik David J.
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Hyperbranched Polymers as Platforms for Catalysts
Authors: Hajji Chakib , Haag Rainer
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Supramolecular Dendritic Catalysis: Noncovalent Catalyst Anchoring to Functionalized Dendrimers
Authors: Ribaudo Fabrizio , van Leeuwen Piet W. N. M. , Reek Joost N. H.
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Anthraquinone and Phenanthrenedione Imines and Diimines
Authors: Avendano C. , Menendez J. C.
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Oxygen‐ and Sulfur‐Containing Hetarene Quinones
Authors: Griesbeck A. G.
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Phenanthrene‐9,10‐diones, Stilbenequinones, Diphenoquinones, and Related Ring Assemblies
Authors: Echavarren A. M. , Porcel S.
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Naphtho‐1,2‐, Naphtho‐1,5‐, Naphtho‐1,7‐, Naphtho‐2,3‐, and Naphtho‐2,6‐quinones
Authors: Liao C.‐C. , Peddinti R. K.
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Advances in the Synthesis of Safranal
Authors: Zope Dhananjay D. , Patnekar S. G. , Kanetkar V. R.
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Recent Optimization Highlights of the Georgywood Process
Authors: Barras Jean‐Pierre , Bourdin Bernadette , Schroeder Fridtjof
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Developing the Chemistry of Monovalent Phosphorus
Authors: Mathey Francois
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Silylating Agents
Authors: Pape Peter G.
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Hydroboration
Authors: Zaidlewicz Marek
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Polyketides, Proteins and Genes in Fungi: Programmed Nano‐Machines Begin to Reveal Their Genes
Authors: Cox Russel J.
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Finding Intermediates in the O2 Activation Pathways of Non‐Heme Iron Oxygenases
Authors: Kovaleva E. G. , Neibergall M. B. , Chakrabarty S. , Lipscomb J. D.
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Non‐Heme Fe(IV)—Oxo Intermediates
Authors: Krebs Carsten , Galonic Fujimori Danica , Walsh Christopher T. , Bollinger J. Martin Jr.
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Dioxygen Activation at Non‐Heme Iron: Insights from Rapid Kinetic Studies
Authors: Korendovych Ivan V. , Kryatov Sergey V. , Rybak‐Akimova Elena V.
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
High‐Valent Iron(IV)—Oxo Complexes of Heme and Non‐Heme Ligands in Oxygenation Reactions
Authors: Nam Wonwoo
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Production of Platform Chemicals and Synthesis Gas from Biomass
Authors: Kamm B.
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Molecules that Make Decisions
Authors: Credi Alberto
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
QSRR: Quantitative Structure‐(Chromatographic) Retention Relationships
Authors: Kaliszan Roman
Published: September 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Determination of the absolute configurations of natural products via density functional theory calculations of vibrational circular dichroism, electronic circular dichroism, and optical rotation: The iso‐schizozygane alkaloids isoschizogaline and isoschizogamine
Authors: Stephens Philip J. , Pan Jian‐Jung , Devlin Frank J. , Urbanová Marie , Julínek Ondřej , Hájíček Josef
Published: September 2007

The development of density functional theory (DFT) methods for the calculation of vibrational circular dichroism (VCD), electronic circular dichroism (ECD), and transparent spectral region optical rotation (OR) has revolutionized the determination of the absolute configurations (ACs) of chiral molecules using these chiroptical properties. We report the concerted application of DFT calculations of VCD, ECD, and OR to the determination of the ACs of the isoschizozygane alkaloid natural products, isoschizogaline, and isochizogamine, whose ACs have not previously been determined. The ACs of naturally occurring (−)‐isoschizogaline and (−)‐isoschizogamine, are both determined definitively to be 2R, 7R, 20S, 21S. Chirality, 2008. © 2007 Wiley‐Liss, Inc.
Severe enteropathy among patients with stage II/III colon cancer treated on a randomized trial of bolus 5‐fluorouracil/leucovorin plus or minus oxaliplatin
Authors: Philip Kuebler J. , Colangelo Linda , O'Connell Michael J. , Smith Roy E. , Yothers Greg , Begovic Mirsada , Robinson Bridget , Seay Thomas E. , Wolmark Norman
Published: September 2007

BACKGROUND.

Cases of severe gastrointestinal toxicity were monitored prospectively during NSABP C‐07, a randomized clinical trial of adjuvant therapy for patients with stage II/III colon cancer.

METHODS.

Patients were treated with weekly bolus 5‐fluorouracil (5‐FU) and leucovorin (FL; “Roswell Park Regimen”) or the same regimen plus oxaliplatin (FLOX).

RESULTS.

Of 1857 patients, 79 (4.3%) developed a syndrome of bowel wall injury (BWI, small or large) characterized by hospitalization for the management of severe diarrhea or dehydration and radiographic or endoscopic evidence of bowel wall thickening or ulceration. Fifty‐one (64.6%) of these adverse events occurred in patients treated with FLOX and 28 (35.4%) in those treated with FL (P < .01). Enteric sepsis (ES), characterized by grade 3 or greater diarrhea and grade 4 neutropenia with or without proven bacteremia occurred in 22 patients treated with FLOX, versus 8 in those treated with FL (P = .01). Patients >60 years were at higher risk for BWI after treatment with FLOX (6.7%) versus treatment with FL (2.9%, P < .01). Female patients had a higher incidence of BWI with FLOX (9.1%) than with FL (3.9%, P < .01). Severe gastrointestinal toxicity usually occurred during the third or fourth week on the first cycle of therapy, required hospitalization, and was managed with fluids, antidiarrheals, and antibiotics. There were 5 deaths (0.3%) due to enteropathy, 2 related to ES and 3 related to both BWI and ES. Seventy‐one percent of patients resumed treatment with FL after recovery.

CONCLUSIONS.

Patients treated with adjuvant FL should be closely monitored for diarrhea and aggressively managed, especially if oxaliplatin has been added to the regimen. Cancer 2007. © 2007 American Cancer Society.
Characterization of the melanin‐concentrating hormone neurons activated during paradoxical sleep hypersomnia in rats
Authors: Hanriot Lucie , Camargo Nutabi , Courau Anne Claire , Leger Lucienne , Luppi Pierre Hervé , Peyron Christelle
Published: September 2007

Although the main nodes of the neuronal network that regulate paradoxical sleep (PS), also called rapid eye movement sleep, have been identified in rodents, it still needs to be more thoroughly described. We have recently shown that 58% of a hypothalamic neuronal population, the melanin‐concentrating hormone (MCH) neurons, are activated after a PS hypersomnia and that MCH, when injected intracerebroventricularly, induces a dose‐dependent increase in PS. This suggests that MCH plays a role in PS regulation. Two subpopulations of MCH neurons have been distinguished neurochemically, one that coexpresses cocaine and amphetamine‐regulated transcript (CART) and sends ascending projections to the septum and the hippocampus, the other, the non‐CART MCH neurons, send descending projections to the lower brainstem and the spinal cord. In order to better characterize the PS‐activated MCH neurons it is interesting to determine whether they belong to the first, the second, or both subgroups. We therefore undertook an MCH, CART, and Fos triple immunolabeling study in PS hypersomniac rats. We showed that the MCH neurons activated during PS are part of both subpopulations since we found CART and non‐CART MCH‐activated neurons. Based on these results and the literature, we propose that MCH could be involved in memory processes and in the inhibition of muscle tone during PS. J. Comp. Neurol. 505:147–157, 2007. © 2007 Wiley‐Liss, Inc.
Developmental mechanisms for retinal degeneration in the blind cavefish Astyanax mexicanus
Authors: Alunni Alessandro , Menuet Arnaud , Candal Eva , Pénigault Jean‐Baptiste , Jeffery William R. , Rétaux Sylvie
Published: September 2007

The sighted surface‐dwelling (surface fish, SF) and the blind cave‐living (cavefish, CF) forms of Astyanax mexicanus offer a unique opportunity to study the evolutionary changes in developmental mechanisms that lead to retinal degeneration. Previous data have shown the role of increased midline Sonic Hedgehog (Shh) signalling in cavefish eye degeneration (Yamamoto et al. [2004] Nature 431:844–847). Here, we have compared the major steps of eye development in SF and CF between 14 hours and 5 days of development. We have analyzed cell proliferation through PCNA and phospho‐histone H3 staining and apoptosis through TUNEL and live LysoTracker analysis. We have assessed the expression of the major eye development signalling factors Shh and Fgf8, and the eye patterning genes Pax6, Lhx2, Lhx9, and Vax1, together with the differentiation marker GAD65. We show that eye development is retarded in CF and that cell proliferation in CF retina is proportionately similar to SF during early development, yet the retina degenerates after massive apoptosis in the lens and widespread cell death throughout the neuroretina. Moreover, and surprisingly, the signalling, patterning, and differentiation processes leading to the establishment of retinal layers and cell types happen almost normally in CF, although some signs of disorganization, slight heterochronies, and a lack of expression gradients are observable. Our data demonstrate that the evolutionary process of eye degeneration in the blind CF does not occur because of patterning defects of the retina and are consistent with the proposed scenario in which the trigger for eye degeneration in CF is lens apoptosis. J. Comp. Neurol. 505:221–233, 2007. © 2007 Wiley‐Liss, Inc.
Novel distribution of junctional adhesion molecule‐C in the neural retina and retinal pigment epithelium
Authors: Daniele Lauren L. , Adams Ralf H. , Durante Diane E. , Pugh Edward N. , Philp Nancy J.
Published: September 2007

Junction adhesion molecules‐A, ‐B, and ‐C (Jams) are cell surface glycoproteins that have been shown to play an important role in the assembly and maintenance of tight junctions and in the establishment of epithelial cell polarity. Recent studies reported that Jam‐C mRNA was increased threefold in the all‐cone retina of the Nrl−/− mouse, suggesting that Jam‐C is required for maturation and polarization of cone photoreceptors cells. We examined the expression of Jams in the mouse retina by using confocal immunofluorescence localization. Jam‐C was detected in tight junctions of retinal pigment epithelium (RPE) and at the outer limiting membrane (OLM) in the specialized adherens junctions between Müller and photoreceptor cells. Additionally, Jam‐C labeling was observed in the long apical processes of Müller and RPE cells that extend between the inner segments and outer segments of photoreceptors, respectively. Jam‐B was also detected at the OLM. In the developing retina, Jam‐B and ‐C were detected at the apical junctions of embryonic retinal neuroepithelia, suggesting a role for Jams in retinogenesis. In eyes from Jam‐C−/− mice, retinal lamination, polarity, and photoreceptor morphology appeared normal. Although Jam‐A was not detected at the OLM in wild‐type retinas, it was present at the OLM in retinas of Jam‐C−/− mice. These findings indicate that up‐regulation of Jam‐A in the retina compensates for the loss of Jam‐C. The nonclassical distribution of Jam‐C in the apical membranes of Müller cells and RPE suggests that Jam‐C has a novel function in the retina. J. Comp. Neurol. 505:166–176, 2007. © 2007 Wiley‐Liss, Inc.
Numerical solution of a mathematical model for capillary formation in tumor angiogenesis via the tau method
Authors: Saadatmandi Abbas , Dehghan Mehdi
Published: September 2007

A numerical procedure is developed to obtain the solution of a mathematical model for capillary formation in tumor angiogenesis. The proposed method is based on the shifted Legendre tau technique. Our approach consists of reducing the problem to a set of algebraic equations by expanding the approximate solution as a shifted Legendre polynomial with unknown coefficients. The operational matrices of integral and derivative together with the tau method are then utilized to evaluate the unknown coefficients of shifted Legendre polynomials. Illustrative example is included to demonstrate the validity and applicability of the presented technique. Copyright © 2007 John Wiley & Sons, Ltd.
Flow cytometric lymphocyte subset enumeration: 10 years of external quality assessment in the Benelux countries
Authors: Levering Wilfried H. B. M. , van Wieringen Wessel N. , Kraan Jaco , van Beers Wil A. M. , Sintnicolaas Kees , van Rhenen Dick J. , Gratama Jan W.
Published: September 2007

A biannual external quality assessment (EQA) scheme for flow cytometric lymphocyte immunophenotyping is operational in the Benelux countries since 1996. We studied the effects of the methods used on assay outcome, and whether or not this EQA exercise was effective in reducing between‐laboratory variation. Eighty test samples were distributed in 20 biannual send‐outs. Per send‐out, 50–71 participants were requested to enumerate CD3+, CD4+, and CD8+T cells, B cells, and NK cells, and to provide methodological details. Participants received written debriefings with personalized recommendations after each send‐out. For this report, data were analyzed using robust multivariate regression. Five variables were associated with significant positive or negative bias of absolute lymphocyte subset counts: (i) platform methodology (i.e., single‐platform assays yielded lower CD4+and CD8+T‐cell counts than did dual‐platform assays); (ii) sample preparation technique (i.e., assays based on mononuclear cells isolation yielded lower T‐cell counts than those based on red cell lysis); (iii) gating strategies based on CD45 and sideward scatter gating of lymphocytes yielded higher CD4+T‐cell counts than those based on “backgating” of lymphocytes guided by CD45 and CD14); (iv) stabilized samples were generally associated with higher lymphocyte subset counts than nonstabilized samples; and (v) laboratory. Platform methodology, sample stabilization, and laboratory also affected assay variability. With time, assay variability tended to decline; this trend was significant for B‐cell counts only. In addition, significant bias and variability of results, independent of the variables tested for in this analysis, were also associated with individual laboratories. In spite of our recommendations, participants tended to standardize their techniques mainly with respect to sample preparation and gating strategies, but less with absolute counting techniques. Failure to fully standardize protocols may have led to only modest reductions in variability of results between laboratories. © 2007 Clinical Cytometry Society.
TLR agonists induce the differentiation of human bone marrow CD34+ progenitors into CD11c+ CD80/86+ DC capable of inducing a Th1‐type response
Authors: Sioud Mouldy , Fløisand Yngvar
Published: September 2007

We recently reported that human bone marrow hematopoietic CD34+ progenitors express functional Toll‐like receptors (TLR) and can differentiate into myeloid cells just by stimulation with resiquimod (R848), a specific agonist for TLR7/8. However, the mechanisms by which R848 induces cell differentiation, the effects of other TLR agonists and the functionality of the differentiated cells are not known. Comparable to R848, loxoribine (a TLR7 agonist) and Pam3CSK4 (a TLR2 agonist) induced cytokine production and cell differentiation along the myeloid lineage. R848 and loxoribine were more effective than Pam3CSK4 at inducing the lineage‐negative (CD11c+ CD14–) dendritic cells (DC), whereas Pam3CSK4 was more effective at inducing CD11c+ CD14+ monocytes. Both cell subsets expressed CD80/CD86 and HLA‐DR molecules; however, they showed differential expression of CD1a, CD1b, CD1c, CD11b, CD206 and CD207 markers when compared with each other. Cell differentiation into DC was significantly inhibited by an anti‐TNF‐α nonoclonal antibody. The CD11c+ CD14– subset was isolated and shown to be more potent in stimulating an alloreaction than the CD11c+ CD14+ subset. Collectively, these data highlight the differential effects of TLR agonists on human bone marow CD34+ progenitor cells and provide a new opportunity for generating functional DC that would be useful in cancer vaccination.
Up‐regulation of leukocyte CXCR4 expression by sulfatide: An L‐selectin‐dependent pathway on CD4+ T cells
Authors: Duchesneau Pascal , Gallagher Erin , Walcheck Bruce , Waddell Thomas K.
Published: September 2007

CXCR4 plays significant roles in immune and inflammatory responses and is important for selective recruitment of leukocytes. We previously showed that CXCR4 surface expression of human lymphocytes was affected by sulfatide, an in vivo ligand for L‐selectin. Increased CXCR4 expression was shown to promote biologically relevant functions such as integrin‐dependent adhesion and transmigration. Here, we show that sulfatide‐induced CXCR4 up‐regulation also occurs on other leukocyte subsets in humans and mice. B cells and CD4+CD25+ T cells had the highest CXCR4 up‐regulation after sulfatide stimulation. Transfection of L‐selectin was sufficient for K562 cells to acquire sulfatide‐induced CXCR4 up‐regulation, while analysis of L‐selectin knockout mice revealed that this response was critically L‐selectin dependent only for CD4+ T cells, suggesting an alternative pathway in CD8+ T cells and B cells. Sulfatide triggered several intracellular signaling events in CD4+ T cells, but only tyrosine kinase activation, including members of the Src family, were essential for L‐selectin to CXCR4 signaling. CXCR4 up‐regulation was rapid, enhanced CXCL12‐induced signaling and increased chemotaxis toward CXCL12, and therefore has potentially important roles in vivo. Thus, the response to CXCL12 depends in part on tissue expression of sulfatide and, specifically in CD4+ T cells, also depends on the surface level of L‐selectin.
MyD88‐dependent autoimmune disease in Lyn‐deficient mice
Authors: Silver Karlee L. , Crockford Tanya L. , Bouriez‐Jones Tiphaine , Milling Simon , Lambe Teresa , Cornall Richard J.
Published: September 2007

Recent evidence suggests that systemic autoimmune disease depends on signals from TLR ligands, but little is known about how TLR‐dependent pathways lead to the loss of self tolerance in vivo. To address this, we have examined the role of TLR signaling in Lyn‐deficient mice, which develop an autoimmune disease similar to SLE. We found that absence of the TLR signaling adaptor molecule MyD88 suppresses plasma cell differentiation of switched and unswitched B cells, and prevents the generation of antinuclear IgG antibodies and glomerulonephritis. In mixed chimeras the increased IgM and IgG antibody secretion in Lyn‐deficient mice is at least partially due to B cell‐independent effects of Lyn. We now show that MyD88 deficiency blocks the expansion and activation of DC in which Lyn is also normally expressed, and prevents the hypersecretion of proinflammatory cytokines IL‐6 and IL‐12 by Lyn‐deficient DC. These findings further highlight the important role of TLR‐dependent signals in both lymphocyte activation and autoimmune pathogenesis.