bluuebunny/crossref_metadata_2025 huggingface dataset:
Lottery Ticket Search on Untrained Models with Applied Lottery Sample Selection
Authors: Bluteau Ryan , Gras Robin
Published: April 2023

In this paper, we present a new approach to improve tabular datasets by applying the lottery ticket hypothesis to tabular neural networks. Prior approaches were required to train the original large-sized model to find these lottery tickets. In this paper we eliminate the need to train the original model and discover lottery tickets using networks a fraction of the model’s size. Moreover, we show that we can remove up to 95% of the training dataset to discover lottery tickets, while still maintaining similar accuracy. The approach uses a genetic algorithm (GA) to train candidate pruned models by encoding the nodes of the original model for selection measured by performance and weight metrics. We found that the search process does not require a large portion of the training data, but when the final pruned model is selected it can be retrained on the full dataset, even if it is often not required. We propose a lottery sample hypothesis similar to the lottery ticket hypotheses where a subsample of lottery samples of the training set can train a model with equivalent performance to the original dataset. We show that the combination of finding lottery samples alongside lottery tickets can allow for faster searches and greater accuracy.
Effects of Diabetes and Voluntary Exercise on IgA Concentration and Polymeric Immunoglobulin Receptor Expression in the Submandibular Gland of Rats
Authors: Park Jaebum , Yamamoto Yuko , Hidaka Kouki , Wada-Takahashi Satoko , Takahashi Shun-suke , Morozumi Toshiya , Kubota Nobuhisa , Saita Makiko , Saruta Juri , Sakaguchi Wakako , To Masahiro , Shimizu Tomoko , Mikuni-Takagaki Yuko , Tsukinoki Keiichi
Published: April 2023

Background and Objectives: Patients with diabetes are more susceptible to upper respiratory tract infections (URTIs) because they are easily infected. Salivary IgA (sali-IgA) levels play a major role in transmitting URTIs. Sali-IgA levels are determined by salivary gland IgA production and polymeric immunoglobulin receptor (poly-IgR) expression. However, it is unknown whether salivary gland IgA production and poly-IgR expression are decreased in patients with diabetes. While exercise is reported to increase or decrease the sali-IgA levels, it is unclear how exercise affects the salivary glands of patients with diabetes. This study aimed to determine the effects of diabetes and voluntary exercise on IgA production and poly-IgR expression in the salivary glands of diabetic rats. Materials and Methods: Ten spontaneously diabetic Otsuka Long–Evans Tokushima Fatty (OLETF) rats (eight-week-old) were divided into two groups of five rats each: a non-exercise group (OLETF-C) and a voluntary wheel-running group (OLETF-E). Five Long–Evans Tokushima Otsuka (LETO) rats without diabetes were bred under the same conditions as the OLETF-C. Sixteen weeks after the study began, the submandibular glands (SGs) were collected and analyzed for IgA and poly-IgR expression levels. Results: IgA concentrations and poly-IgR expression levels in SGs were lower in OLETF-C and OLETF-E than in LETO (p < 0.05). These values did not differ between the OLETF-C and OLETF-E. Conclusions: Diabetes decreases IgA production and poly-IgR expression in the salivary glands of rats. Moreover, voluntary exercise increases sali-IgA levels but does not increase IgA production and poly-IgR expression in the salivary glands of diabetic rats. Increasing IgA production and poly-IgR expression in the salivary glands, which is reduced in diabetes, might require slightly higher-intensity exercise than voluntary exercise under the supervision of a doctor.
Inflammatory Myofibroblastic Tumour of the Urinary Bladder in a Middle-Aged Man—A Case Report of an Unusual Localization of a Rare Tumour
Authors: Prijovic Nebojsa , Santric Veljko , Babic Uros , Stankovic Branko , Acimovic Miodrag , Cekerevac Milica , Nikolic Gorana , Cegar Bojan
Published: April 2023

Inflammatory myofibroblastic tumour (IMT) is a rare tumour with an intermediate biological behaviour. It usually occurs in children and adolescents, primarily in the abdomen or lungs. Histopathologically, IMT consists of spindle cells, i.e., myofibroblasts, and a variable inflammatory component. Localization in the urinary bladder is rare. We are presenting a rare case of IMT in the bladder in a middle-aged man treated by partial cystectomy. A 62-year-old man consulted a urologist because of haematuria and dysuric disturbances. A tumorous mass was detected by an ultrasound in the urinary bladder. CT urography described the tumorous mass at the dome of the urinary bladder measuring 2 × 5 cm. A smooth tumorous mass was cystoscopically observed at the dome of the urinary bladder. Transurethral resection of the bladder tumour was performed. Histopathological analysis of the specimen identified spindle cells with a mixed inflammatory infiltrate; immunohistochemical findings showed positivity for anaplastic lymphoma kinase (ALK), smooth muscle actin (SMA) and vimentin. A histopathological diagnosis of IMT was established. It was decided that the patient would undergo a partial cystectomy. A complete excision of the tumour from the dome of the urinary bladder with surrounding healthy tissue was performed. Histopathological and immunohistochemical findings of the sample confirmed the diagnosis of IMT, without the presence of the tumour at the surgical margins. The postoperative course went smoothly. IMT is a rare tumour in adults, especially localised in the urinary bladder. IMT of the urinary bladder is difficult to distinguish from urinary bladder malignancy both clinically and radiologically, as well as histopathologically. If the location and size of the tumour allow it, bladder-preserving surgeries such as partial cystectomy represent a reasonable modality of operative treatment.
Phase Equilibrium Studies of the CaO-MgO-Al2O3-SiO2 System for Iron Blast Furnace Slag: A Review
Authors: Liao Jinfa , Qing Gele , Zhao Baojun
Published: April 2023

More and larger blast furnaces have been constructed for ironmaking across the world in recent years due to the advantages of high productivity, high energy efficiency and low cost. Slag plays important role in a blast furnace to produce high-quality hot metal and maintain smooth operations. Liquidus temperatures are the essential information of the slag to avoid the formation of the solid phase during the ironmaking process and slag tapping. The principal components of the iron blast furnace slags can be described by the system CaO-MgO-Al2O3-SiO2. With the significant changes in the raw materials and different requirements of the blast furnace operations, phase equilibria in this slag system have been extensively investigated from different directions. Phase diagrams were presented in various pseudo-ternary and pseudo-binary forms to meet the requirements of wide applications. Reliable thermodynamic modelling is the target of the researchers which can predict accurate liquidus temperatures of the slag. Development of the reliable thermodynamic modelling relies on systematic and accurate experimental data including liquidus temperatures and compositions of the solid solutions. Experimental data on the phase equilibria of the system CaO-MgO-Al2O3-SiO2 are summarised and compared with the thermodynamic predictions which can provide systematic information for the researchers and blast furnace operators.
Melatonin and TGF-β-Mediated Release of Extracellular Vesicles
Authors: Piekarska Klaudia , Bonowicz Klaudia , Grzanka Alina , Jaworski Łukasz M. , Reiter Russel J. , Slominski Andrzej T. , Steinbrink Kerstin , Kleszczyński Konrad , Gagat Maciej
Published: April 2023

The immune system, unlike other systems, must be flexible and able to “adapt” to fully cope with lurking dangers. The transition from intracorporeal balance to homeostasis disruption is associated with activation of inflammatory signaling pathways, which causes modulation of the immunology response. Chemotactic cytokines, signaling molecules, and extracellular vesicles act as critical mediators of inflammation and participate in intercellular communication, conditioning the immune system’s proper response. Among the well-known cytokines allowing for the development and proper functioning of the immune system by mediating cell survival and cell-death-inducing signaling, the tumor necrosis factor α (TNF-α) and transforming growth factor β (TGF-β) are noteworthy. The high bloodstream concentration of those pleiotropic cytokines can be characterized by anti- and pro-inflammatory activity, considering the powerful anti-inflammatory and anti-oxidative stress capabilities of TGF-β known from the literature. Together with the chemokines, the immune system response is also influenced by biologically active chemicals, such as melatonin. The enhanced cellular communication shows the relationship between the TGF-β signaling pathway and the extracellular vesicles (EVs) secreted under the influence of melatonin. This review outlines the findings on melatonin activity on TGF-β-dependent inflammatory response regulation in cell-to-cell communication leading to secretion of the different EV populations.
Development of Split Ring Resonator Shaped Six Element 2 × 3 Multiple Input Multiple Output Antenna for the C/X/Ku/K Band Applications
Authors: Alsharari Meshari , Sorathiya Vishal , Armghan Ammar , Dave Kavan , Aliqab Khaled
Published: April 2023

In this manuscript, we have numerically investigated and experimentally verified the six-element split ring resonator and circular patch-shaped multiple input, multiple output antenna operating in the 1–25 GHz band. MIMO antennas are analyzed in terms of several physical parameters, such as reflectance, gain, directivity, VSWR, and electric field distribution. The parameters of the MIMO antenna, for instance, the envelope correlation coefficient (ECC), channel capacity loss (CCL), the total active reflection coefficient (TARC), directivity gain (DG), and mean effective gain (MEG), are also investigated for identification of a suitable range of these parameters for multichannel transmission capacity. Ultrawideband operation at 10.83 GHz is possible for the theoretically designed and practically executed antenna with the return loss and gain values of −19 dB and −28 dBi, respectively. Overall, the antenna offers minimum return loss values of −32.74 dB for the operating band of 1.92 to 9.81 GHz with a bandwidth of 6.89 GHz. The antennas are also investigated in terms of a continuous ground patch and a scattered rectangular patch. The proposed results are highly applicable for the ultrawideband operating MIMO antenna application in satellite communication with C/X/Ku/K bands.
Mineralogy and Mineral Chemistry of the Au-Ag-Te-(Bi-Se) San Luis Alta Deposit, Mid-South Peru
Authors: Alfonso Pura , Ccolqque Elsa , Garcia-Valles Maite , Martínez Arnau , Yubero Maria Teresa , Anticoi Hernan , Sidki-Rius Nor
Published: April 2023

A mineralogical and mineral chemistry study was carried out in the San Luis Alta telluride-rich gold deposit, mid-south Peru, to contribute towards determining its formation and improving the ore processing. The San Luis mineralization is considered an intrusion-related gold deposit located in the Arequipa segment of the Coastal Batholith. The mineralization occurs in quartz veins hosted in diorites and granodiorites from the Tiabaya Super-Unit. These veins are sulfide-rich in the deep areas and contain abundant iron oxides. Sulfides are mainly pyrite with minor chalcopyrite and galena. Native gold and telluride minerals are abundant. Mineral chemistry was determined using an electron microprobe. The mineralogy of veins was classified into four stages. Gold occurs in the three last stages either in large grains, visible to the naked eye, or, more frequently, in grains of less than 10 µm. Gold appears as grains encapsulated in pyrite, Fe oxides, quartz and filling fractures. The first stage is characterized by the deposition of quartz and massive pyrite, which does not contain gold. During the second stage, hessite, calaverite, petzite and altaite are formed. Additionally, Bi-tellurides, mainly volynskite, rucklidgeite, kochkarite and tellurobusmuthine, are formed. Some of these minerals occur as blebs encapsulated in pyrite, suggesting that a Bi-Te-rich melt was formed from the ore-forming hydrothermal fluid and transported the Au and Ag elements. This stage was followed by a fracturing event and tellurobismuthite, tetradymite and montbrayite precipitated. In the last stage, a supergene replacement formed covellite, bornite and goethite. Te-Bi minerals do not appear in this stage, but selenium minerals occur in minor amounts. Chlorargyrite and iodargyrite occur and are associated with gold.
Research on Engineering Practice and Effect Evaluation Method of Pressure Relief in Deep Rock Burst Danger Area of Coal Mine
Authors: Li Jiazhuo , Liu Shun , Ren Wentao , Liu Hui , Li Songyue , Yan Kangxing
Published: April 2023

With a gradual increase in coal mining depth, the underground geological situation is more complex and the threat of rock bursts is more prominent due to the cross influence of multiple factors, such as faults, thick hard roofs, coal pillars, and high in situ stress areas. Additionally, it is difficult to test the effectiveness of multiple pressure relief measures after implementation in mining areas with rock burst dangers. By evaluating the geology and mining conditions of panel 5308 of the Tangkou coal mine, pressure relief prevention and control technology, combining pre-pressure relief and a danger relief measure, was proposed. An evaluation method for pressure relief implementation in deep mine rock burst danger areas was proposed, with changing rates of event frequency in microseismic high-energy intervals, changing rates of the mean values of hydraulic-powered support stress, and changing rates of bursting strain energy as evaluation indicators. The weight of each indicator was determined based on an analytic hierarchy process. The degree of pressure relief was measured by the pressure relief interval index. The comprehensive pressure relief effect index was calculated by an interval index and by a weight vector. Additionally, the classification standard of the pressure relief effect was proposed. The results show that the frequency of microseismic high-energy interval events decreased by 34.9%, the mean value of hydraulic-powered support stress decreased by 12.7%, and the bursting strain energy decreased by 14.7% after pressure relief was applied at panel 5308. Additionally, the interval indexes corresponding to each indicator were 3, 2, and 2 and the pressure relief effect index was 2.55, so the destress effect was good. The drilling method monitoring data show that the average value of the drilling powder decreased by 18% after pressure relief compared with before and the overall effect was good, which is consistent with the evaluation results of the multi-dimensional pressure relief implementation effect evaluation system, indicating that the evaluation system can accurately test the effectiveness of the multi-dimensional pressure relief implementation effect in deep mine rock burst danger areas. The results of the study provide methodological support and reference for the monitoring and prevention of rock bursts in mines with similar geological conditions.
Value-Added Products from Coffee Waste: A Review
Authors: Lee Yoon-Gyo , Cho Eun-Jin , Maskey Shila , Nguyen Dinh-Truong , Bae Hyeun-Jong
Published: April 2023

Coffee waste is often viewed as a problem, but it can be converted into value-added products if managed with clean technologies and long-term waste management strategies. Several compounds, including lipids, lignin, cellulose and hemicelluloses, tannins, antioxidants, caffeine, polyphenols, carotenoids, flavonoids, and biofuel can be extracted or produced through recycling, recovery, or energy valorization. In this review, we will discuss the potential uses of by-products generated from the waste derived from coffee production, including coffee leaves and flowers from cultivation; coffee pulps, husks, and silverskin from coffee processing; and spent coffee grounds (SCGs) from post-consumption. The full utilization of these coffee by-products can be achieved by establishing suitable infrastructure and building networks between scientists, business organizations, and policymakers, thus reducing the economic and environmental burdens of coffee processing in a sustainable manner.
Hypolipidemic and Anti-Atherogenic Effects of Sesamol and Possible Mechanisms of Action: A Comprehensive Review
Authors: Majdalawieh Amin F. , Eltayeb Aaram E. , Abu-Yousef Imad A. , Yousef Sarah M.
Published: April 2023

Sesamol is a phenolic lignan isolated from Sesamum indicum seeds and sesame oil. Numerous studies have reported that sesamol exhibits lipid-lowering and anti-atherogenic properties. The lipid-lowering effects of sesamol are evidenced by its effects on serum lipid levels, which have been attributed to its potential for significantly influencing molecular processes involved in fatty acid synthesis and oxidation as well as cholesterol metabolism. In this review, we present a comprehensive summary of the reported hypolipidemic effects of sesamol, observed in several in vivo and in vitro studies. The effects of sesamol on serum lipid profiles are thoroughly addressed and evaluated. Studies highlighting the ability of sesamol to inhibit fatty acid synthesis, stimulate fatty acid oxidation, enhance cholesterol metabolism, and modulate macrophage cholesterol efflux are outlined. Additionally, the possible molecular pathways underlying the cholesterol-lowering effects of sesamol are presented. Findings reveal that the anti-hyperlipidemic effects of sesamol are achieved, at least in part, by targeting liver X receptor α (LXRα), sterol regulatory element binding protein-1 (SREBP-1), and fatty acid synthase (FAS) expression, as well as peroxisome proliferator-activated receptor α (PPARα) and AMP activated protein kinase (AMPK) signaling pathways. A detailed understanding of the molecular mechanisms underlying the anti-hyperlipidemic potential of sesamol is necessary to assess the possibility of utilizing sesamol as an alternative natural therapeutic agent with potent hypolipidemic and anti-atherogenic properties. Research into the optimal sesamol dosage that may bring about such favorable hypolipidemic effects should be further investigated, most importantly in humans, to ensure maximal therapeutic benefit.
Heat Shock Proteins: Important Helpers for the Development, Maintenance and Regeneration of Skeletal Muscles
Authors: Pomella Silvia , Cassandri Matteo , Antoniani Francesco , Crotti Samuele , Mediani Laura , Silvestri Beatrice , Medici Margherita , Rota Rossella , Rosa Alessandro , Carra Serena
Published: April 2023

The skeletal muscle is a highly plastic tissue that shows a remarkable adaptive capacity in response to acute and resistance exercise, and modifies its composition to adapt to use and disuse, a process referred to as muscle plasticity. Heat shock proteins (HSPs), a class of evolutionarily conserved molecular chaperones, have been implicated in the regulation of skeletal muscle plasticity. Here, we summarize key findings supporting the notion that HSPs are important components required to maintain skeletal muscle integrity and functionality. HSPs participate in the transcriptional program required for myogenesis and are activated following muscle exercise and injury. Their dysfunction, either as a consequence of improper expression or genetic mutations, contributes to muscle atrophy and leads to the development of myopathies and peripheral motor neuropathies. Denervation/reinnervation and repeated rounds of nerve degeneration/regeneration have been observed in motor neuropathies, suggesting that an imbalance in HSP expression and function may impair the repair of the neuromuscular junctions. Boosting HSP activity may help preventing muscle atrophy by promoting muscle differentiation and helping the repair of NMJs. Boosting HSP function may also help to combat the development of rhabdomyosarcoma (RMS), a highly aggressive type of pediatric soft tissue sarcoma whose cells have skeletal muscle features but are unable to fully differentiate into skeletal muscle cells.
A Review on Recent Progress in Preparation of Medium-Temperature Solar-Thermal Nanofluids with Stable Dispersion
Authors: Hu Ting , Zhang Jingyi , Xia Ji , Li Xiaoxiang , Tao Peng , Deng Tao
Published: April 2023

Direct absorption of sunlight and conversion into heat by uniformly dispersed photothermal nanofluids has emerged as a facile way to efficiently harness abundant renewable solar-thermal energy for a variety of heating-related applications. As the key component of the direct absorption solar collectors, solar-thermal nanofluids, however, generally suffer from poor dispersion and tend to aggregate, and the aggregation and precipitation tendency becomes even stronger at elevated temperatures. In this review, we overview recent research efforts and progresses in preparing solar-thermal nanofluids that can be stably and homogeneously dispersed under medium temperatures. We provide detailed description on the dispersion challenges and the governing dispersion mechanisms, and introduce representative dispersion strategies that are applicable to ethylene glycol, oil, ionic liquid, and molten salt-based medium-temperature solar-thermal nanofluids. The applicability and advantages of four categories of stabilization strategies including hydrogen bonding, electrostatic stabilization, steric stabilization, and self-dispersion stabilization in improving the dispersion stability of different type of thermal storage fluids are discussed. Among them, recently emerged self-dispersible nanofluids hold the potential for practical medium-temperature direct absorption solar-thermal energy harvesting. In the end, the exciting research opportunities, on-going research need and possible future research directions are also discussed. It is anticipated that the overview of recent progress in improving dispersion stability of medium-temperature solar-thermal nanofluids can not only stimulate exploration of direct absorption solar-thermal energy harvesting applications, but also provide a promising means to solve the fundamental limiting issue for general nanofluid technologies.
Aqueous Pb(II) Removal Using ZIF-60: Adsorption Studies, Response Surface Methodology and Machine Learning Predictions
Authors: Ismail Usman M. , Onaizi Sagheer A. , Vohra Muhammad S.
Published: April 2023

Zeolitic imidazolate frameworks (ZIFs) are increasingly gaining attention in many application fields due to their outstanding porosity and thermal stability, among other exceptional characteristics. However, in the domain of water purification via adsorption, scientists have mainly focused on ZIF-8 and, to a lesser extent, ZIF-67. The performance of other ZIFs as water decontaminants is yet to be explored. Hence, this study applied ZIF-60 for the removal of lead from aqueous solutions; this is the first time ZIF-60 has been used in any water treatment adsorption study. The synthesized ZIF-60 was subjected to characterization using FTIR, XRD and TGA. A multivariate approach was used to investigate the effect of adsorption parameters on lead removal and the findings revealed that ZIF-60 dose and lead concentration are the most significant factors affecting the response (i.e., lead removal efficiency). Further, response surface methodology-based regression models were generated. To further explore the adsorption performance of ZIF-60 in removing lead from contaminated water samples, adsorption kinetics, isotherm and thermodynamic investigations were conducted. The findings revealed that the obtained data were well-fitted by the Avrami and pseudo-first-order kinetic models, suggesting that the process is complex. The maximum adsorption capacity (qmax) was predicted to be 1905 mg/g. Thermodynamic studies revealed an endothermic and spontaneous adsorption process. Finally, the experimental data were aggregated and used for machine learning predictions using several algorithms. The model generated by the random forest algorithm proved to be the most effective on the basis of its significant correlation coefficient and minimal root mean square error (RMSE).
Corrosion Resistance of Nanostructured Cemented Carbides with Alternative FeNi and FeNiCo Binders
Authors: Aleksandrov Fabijanić Tamara , Šnajdar Mateja , Kurtela Marin , Šimunović Vedran , Marciuš Marijan , Klaić Miho
Published: April 2023

Nanostructured cemented carbides with Co binders have shown excellent mechanical properties in various applications. Nevertheless, their corrosion resistance has shown to be insufficient in different corrosive environments, leading to premature tool failure. In this study, WC-based cemented carbide samples with different binders were produced using 9 wt% of FeNi or FeNiCo with the addition of Cr3C2 and NbC as the grain growth inhibitors. The samples were investigated using electrochemical corrosion techniques: the open circuit potential Ecorr, the linear polarization resistance (LPR), the Tafel extrapolation method, and the electrochemical impedance spectroscopy (EIS) at room temperature in the solution of 3.5% NaCl. Microstructure characterization, surface texture analysis, and instrumented indentation were conducted to investigate the influence of corrosion on the micro-mechanical properties and the surface characteristics of the samples before and after corrosion. The obtained results indicate a strong binder chemical composition’s effect on the consolidated materials’ corrosive behavior. Compared to the conventional WC-Co systems, a significantly improved corrosion resistance was observed for both alternative binder systems. The study shows that the samples with the FeNi binder are superior to those with the FeNiCo binder since they were almost unaffected when exposed to the acidic medium.
Bifunctional Bicarbazole-Benzophenone-Based Twisted Donor–Acceptor–Donor Derivatives for Deep-Blue and Green OLEDs
Authors: Gautam Prakalp , Shahnawaz  , Siddiqui Iram , Blazevicius Dovydas , Krucaite Gintare , Tavgeniene Daiva , Jou Jwo-Huei , Grigalevicius Saulius
Published: April 2023

Organic light-emitting diodes (OLEDs) have played a vital role in showing tremendous technological advancements for a better lifestyle, due to their display and lighting technologies in smartphones, tablets, television, and automotive industries. Undoubtedly, OLED is a mainstream technology and, inspired by its advancements, we have designed and synthesized the bicarbazole-benzophenone-based twisted donor–acceptor–donor (D-A-D) derivatives, namely DB13, DB24, DB34, and DB43, as bi-functional materials. These materials possess high decomposition temperatures (>360 °C) and glass transition temperatures (~125 °C), a high photoluminescence quantum yield (>60%), wide bandgap (>3.2 eV), and short decay time. Owing to their properties, the materials were utilized as blue emitters as well as host materials for deep-blue and green OLEDs, respectively. In terms of the blue OLEDs, the emitter DB13-based device outperformed others by showing a maximum EQE of 4.0%, which is close to the theoretical limit of fluorescent materials for a deep-blue emission (CIEy = 0.09). The same material also displayed a maximum power efficacy of 45 lm/W as a host material doped with a phosphorescent emitter Ir(ppy)3. Furthermore, the materials were also utilized as hosts with a TADF green emitter (4CzIPN) and the device based on DB34 displayed a maximum EQE of 11%, which may be attributed to the high quantum yield (69%) of the host DB34. Therefore, the bi-functional materials that are easily synthesized, economical, and possess excellent characteristics are expected to be useful in various cost-effective and high-performance OLED applications, especially in displays.
Structures, Sources, Identification/Quantification Methods, Health Benefits, Bioaccessibility, and Products of Isorhamnetin Glycosides as Phytonutrients
Authors: Wang Hong , Chen Lijia , Yang Binrui , Du Jun , Chen Liang , Li Yiming , Guo Fujiang
Published: April 2023

In recent years, people have tended to consume phytonutrients and nutrients in their daily diets. Isorhamnetin glycosides (IGs) are an essential class of flavonoids derived from dietary and medicinal plants such as Opuntia ficus-indica, Hippophae rhamnoides, and Ginkgo biloba. This review summarizes the structures, sources, quantitative and qualitative analysis technologies, health benefits, bioaccessibility, and marketed products of IGs. Routine and innovative assay methods, such as IR, TLC, NMR, UV, MS, HPLC, UPLC, and HSCCC, have been widely used for the characterization and quantification of IGs. All of the therapeutic effects of IGs discovered to date are collected and discussed in this study, with an emphasis on the relevant mechanisms of their health-promoting effects. IGs exhibit diverse biological activities against cancer, diabetes, hepatic diseases, obesity, and thrombosis. They exert therapeutic effects through multiple networks of underlying molecular signaling pathways. Owing to these benefits, IGs could be utilized to make foods and functional foods. IGs exhibit higher bioaccessibility and plasma concentrations and longer average residence time in blood than aglycones. Overall, IGs as phytonutrients are very promising and have excellent application potential.
Short-Term L-Citrulline Supplementation Does Not Affect Inspiratory Muscle Oxygenation and Respiratory Performance in Older Adults
Authors: Theodorou Anastasios A. , Chatzinikolaou Panagiotis N. , Margaritelis Nikos V. , Christodoulou Filippos , Tsatalas Themistoklis , Paschalis Vassilis
Published: April 2023

In sports nutrition, nitric oxide (NO•) precursors such as L-citrulline are widely used to enhance NO• bioavailability, which is considered an ergogenic aid. Our study aimed to examine the effect of short-term L-citrulline supplementation on respiratory muscles’ performance, fatigue, and oxygenation in older adults. Fourteen healthy older males took 6 g of L-citrulline or a placebo for seven days in a double-blind crossover design. Pulmonary function via spirometry (i.e., forced expired volume in 1 s (FEV1), forced vital capacity (FVC), and their ratio)), fractional exhaled nitric oxide (NO•), maximal inspiratory pressure (MIP), rate of perceived exertion, and sternocleidomastoid muscle oxygenation (i.e., oxyhemoglobin (Δ[O2Hb]) and de-oxyhemoglobin (Δ[HHb]), total hemoglobin concentration (Δ[tHb]), and tissue saturation index (TSI%)) were evaluated at baseline, after seven days of L-citrulline supplementation, and after incremental resistive breathing to task failure of the respiratory muscles. The exhaled NO• value was only significantly increased after the supplementation (26% p < 0.001) in the L-citrulline condition. Pulmonary function, MIP, rate of perceived exertion, and sternocleidomastoid muscle oxygenation were not affected by the L-citrulline supplementation. In the present study, although short-term L-citrulline supplementation increased exhaled NO•, no ergogenic aids were found on the examined parameters at rest and after resistive breathing to task failure in older adults.
Emerging Dietary Bioactives in Health and Disease
Authors: Tako Elad
Published: April 2023

This monograph, based on a Special Issue of Nutrients, contains 16 manuscripts—2 review manuscripts and 14 original research manuscripts—that reflect the wide spectrum of currently conducted research in the field of Emerging Dietary Bioactives in Health and Disease [...]
Outcomes of a Caregiver-Focused Short Message Service (SMS) Intervention to Reduce Intake of Sugar-Sweetened Beverages in Rural Caregivers and Adolescents
Authors: Brock Donna-Jean P. , Yuhas Maryam , Porter Kathleen J. , Chow Philip I. , Ritterband Lee M. , Tate Deborah F. , Zoellner Jamie M.
Published: April 2023

This study examined enrollment, retention, engagement, and behavior changes from a caregiver short message service (SMS) component of a larger school-based sugar-sweetened beverage (SSB) reduction intervention. Over 22 weeks, caregivers of seventh graders in 10 Appalachian middle schools received a two-way SMS Baseline Assessment and four monthly follow-up assessments to report their and their child’s SSB intake and select a personalized strategy topic. Between assessments, caregivers received two weekly one-way messages: one information or infographic message and one strategy message. Of 1873 caregivers, 542 (29%) enrolled by completing the SMS Baseline Assessment. Three-quarters completed Assessments 2–5, with 84% retained at Assessment 5. Reminders, used to encourage adherence, improved completion by 19–40%, with 18–33% completing after the first two reminders. Most caregivers (72–93%) selected a personalized strategy and an average of 28% viewed infographic messages. Between Baseline and Assessment 5, daily SSB intake frequency significantly (p < 0.01) declined for caregivers (−0.32 (0.03), effect size (ES) = 0.51) and children (−0.26 (0.01), ES = 0.53). Effect sizes increased when limited to participants who consumed SSB twice or more per week (caregivers ES = 0.65, children ES = 0.67). Findings indicate that an SMS-delivered intervention is promising for engaging rural caregivers of middle school students and improving SSB behaviors.
Anti-Steatotic Effects of Chlorella vulgaris, Nannochloropsis gaditana and Gracilaria vermiculophylla Algae Extracts in AML-12 Hepatocytes
Authors: González-Arceo Maitane , Trepiana Jenifer , Aguirre Leixuri , Ibarruri Jone , Martínez-Sanz Marta , Cebrián Marta , Recio Isidra , Portillo María P. , Gómez-Zorita Saioa
Published: April 2023

Non-alcoholic fatty liver disease (NAFLD) is considered the most common chronic liver alteration whose prevalence is increasing in Western countries. Microalgae and macroalgae have attracted great interest due to the high content in bioactive compounds with beneficial effects on health. The aim of the present study is to assess the potential interest of extracts rich in proteins obtained from the microalgae Chlorella vulgaris and Nannochloropsis gaditana and the macroalga Gracilaria vermiculophylla in the prevention of lipid accumulation in AML-12 hepatocytes. Toxicity was not observed at any of the tested doses. Both microalgae and the macroalga were effective in preventing triglyceride accumulation, with Nannochloropsis gaditana being the most effective one. Although the three algae extracts were able to increase different catabolic pathways involved in triglyceride metabolism, the mechanisms underlying the anti-steatotic effect were different in each algae extract. In conclusion, the present study demonstrates that Chlorella vulgaris, Nannochloropsis gaditana and Gracilaria vermiculophylla extracts are able to partially prevent the accumulation of triglycerides induced by palmitic acid in cultured hepatocytes, a model used to mimic the steatosis induced in liver by dietary patterns rich in saturated fat.
Tsunami-Driven Spread of Toxoplasma gondii and Other Microbial Pathogens: Implications for Cetacean Health and Conservation
Authors: Di Guardo Giovanni
Published: April 2023

Six years have now gone by since Dr James T [...]
Preparation and Bioevaluation of a Novel 99mTc-Labeled Glucose Derivative Containing Cyclohexane as a Promising Tumor Imaging Agent
Authors: Feng Junhong , Zhang Xuran , Jiang Yuhao , Ruan Qing , Wang Qianna , Zhang Junbo
Published: April 2023

To develop novel tumor imaging agents with high tumor uptake and excellent tumor/non-target ratios, a glucose derivative containing cyclohexane (CNMCHDG) was synthesized and labeled with Tc-99m. [99mTc]Tc-CNMCHDG was prepared by a kit formulation that was straightforward to operate and fast. Without purification, [99mTc]Tc-CNMCHDG had a high radiochemical purity of over 95% and great in vitro stability and hydrophilicity (log P = −3.65 ± 0.10). In vitro cellular uptake studies showed that the uptake of [99mTc]Tc-CNMCHDG was significantly inhibited by pre-treatment with D-glucose and increased by pre-treatment with insulin. Preliminary cellular studies have demonstrated that the mechanism by which the complex enters into cells may be related to GLUTs. The results of biodistribution and SPECT imaging studies displayed high tumor uptake and good retention of [99mTc]Tc-CNMCHDG in A549 tumor-bearing mice (4.42 ± 0.36%ID/g at 120 min post-injection). Moreover, [99mTc]Tc-CNMCHDG exhibited excellent tumor-to-non-target ratios and a clean imaging background and is a potential candidate for clinical transformation.
High-Throughput/High Content Imaging Screen Identifies Novel Small Molecule Inhibitors and Immunoproteasomes as Therapeutic Targets for Chordoma
Authors: Ajay Amrendra K. , Chu Philip , Patel Poojan , Deban Christa , Roychowdhury Chitran , Heda Radhika , Halawi Ahmad , Saad Anis , Younis Nour , Zhang Hao , Jiang Xiuju , Nasr Mahmoud , Hsiao Li-Li , Lin Gang , Azzi Jamil R.
Published: April 2023

Chordomas account for approximately 1–4% of all malignant bone tumors and 20% of primary tumors of the spinal column. It is a rare disease, with an incidence estimated to be approximately 1 per 1,000,000 people. The underlying causative mechanism of chordoma is unknown, which makes it challenging to treat. Chordomas have been linked to the T-box transcription factor T (TBXT) gene located on chromosome 6. The TBXT gene encodes a protein transcription factor TBXT, or brachyury homolog. Currently, there is no approved targeted therapy for chordoma. Here, we performed a small molecule screening to identify small chemical molecules and therapeutic targets for treating chordoma. We screened 3730 unique compounds and selected 50 potential hits. The top three hits were Ribociclib, Ingenol-3-angelate, and Duvelisib. Among the top 10 hits, we found a novel class of small molecules, including proteasomal inhibitors, as promising molecules that reduce the proliferation of human chordoma cells. Furthermore, we discovered that proteasomal subunits PSMB5 and PSMB8 are increased in human chordoma cell lines U-CH1 and U-CH2, confirming that the proteasome may serve as a molecular target whose specific inhibition may lead to better therapeutic strategies for chordoma.
All-Glass Single-Mode Leakage Channel Microstructured Optical Fibers with Large Mode Area and Low Bending Loss
Authors: Denisov Alexander , Dvoyrin Vladislav , Kosolapov Alexey , Likhachev Mikhail , Velmiskin Vladimir , Zhuravlev Sergey , Semjonov Sergey
Published: April 2023

The paper presents the results of theoretical and experimental studies of all-glass leakage channel microstructured optical fibers (MOFs) with a large mode area and low bending losses. These MOFs contain two layers of fluorine-doped silica glass elements with a reduced refractive index, different diameters, and different distances between them. A numerical analysis of the properties of these MOFs was performed using the finite element method. The leakage losses for the fundamental and higher-order modes were calculated in the spectral range from 0.65 μm to 1.65 μm. Simulation results show that the proposed MOF design allows for single-mode guidance in the spectral range from 0.92 μm to 1.21 μm with a bending radius of down to 0.08 m. The measured losses of the fabricated MOF with a core diameter of 22.5 μm and a bending radius of 0.1 m were less than 0.1 dB/m in the spectral range from 0.9 μm to 1.5 μm. It is demonstrated that the segments of this MOF longer than 5 m are single-mode.
An Introduction to Noncommutative Physics
Authors: Liang Shi-Dong , Lake Matthew J.
Published: April 2023

Noncommutativity in physics has a long history, tracing back to classical mechanics. In recent years, many new developments in theoretical physics, and in practical applications rely on different techniques of noncommutative algebras. In this review, we introduce the basic concepts and techniques of noncommutative physics in a range of areas, including classical physics, condensed matter systems, statistical mechanics, and quantum mechanics, and we present some important examples of noncommutative algebras, including the classical Poisson brackets, the Heisenberg algebra, Lie and Clifford algebras, the Dirac algebra, and the Snyder and Nambu algebras. Potential applications of noncommutative structures in high-energy physics and gravitational theory are also discussed. In particular, we review the formalism of noncommutative quantum mechanics based on the Seiberg–Witten map and propose a parameterization scheme to associate the noncommutative parameters with the Planck length and the cosmological constant. We show that noncommutativity gives rise to an effective gauge field, in the Schrödinger and Pauli equations. This term breaks translation and rotational symmetries in the noncommutative phase space, generating intrinsic quantum fluctuations of the velocity and acceleration, even for free particles. This review is intended as an introduction to noncommutative phenomenology for physicists, as well as a basic introduction to the mathematical formalisms underlying these effects.
p-Mode Oscillations in Highly Gravitationally Stratified Magnetic Solar Atmospheres
Authors: Griffiths Michael , Gyenge Norbert , Zheng Ruisheng , Korsós Marianna , Erdélyi Robertus
Published: April 2023

The aim of the study reported in this paper is to gain understanding of solar global oscillations and the propagation characteristics of p-mode oscillations in the highly gravitationally stratified magnetic solar atmosphere. The paper presents the results of 3D (3-dimensional) numerical magnetohydrodynamic (MHD) simulations of a model solar atmosphere with a uniform, vertical and cylindrically symmetric magnetic field. We use simulation drivers which result in oscillations mimicking the behaviour of p-mode oscillations. The paper reports the variation of the energy flux and oscillation frequency of the magnetosonic modes and examines their dependence on the magnetic field strength. We report results for the temporal analysis of observational data for the quiet Sun and for a region containing a small sunspot (solar pore). We compare the temporal analysis of results from observations of these ubiquitous intensity oscillations with numerical simulations of potential signatures of global oscillations of the solar atmosphere. We conclude that magnetic regions of the solar atmosphere are favourable regions for the propagation of a small leakage of energy by slow magnetosonic modes. The results also exhibit a variation in the frequency of the oscillations at different heights in the low-to-mid solar atmosphere and for different values of the magnetic field. The numerically obtained periodic behaviour and variation in frequency, even in this simplified model atmosphere, is consistent with the observational data. We find frequencies and frequency variations that are similar to measurements obtained from the intensity time series of images taken by the Solar Dynamics Observatory.
Engineering Cell Microenvironment Using Nanopattern-Derived Multicellular Spheroids and Photo-Crosslinked Gelatin/Hyaluronan Hydrogels
Authors: Zhang Zhen , Liu Yi , Tao Xuelian , Du Ping , Enkhbat Myagmartsend , Lim Khoon S. , Wang Huaiyu , Wang Peng-Yuan
Published: April 2023

Cell cultures of dispersed cells within hydrogels depict the interaction of the cell–extracellular matrix (ECM) in 3D, while the coculture of different cells within spheroids combines both the effects of cell–cell and cell–ECM interactions. In this study, the cell co-spheroids of human bone mesenchymal stem cells/human umbilical vein endothelial cells (HBMSC/HUVECs) are prepared with the assistance of a nanopattern, named colloidal self-assembled patterns (cSAPs), which is superior to low-adhesion surfaces. A phenol-modified gelatin/hyaluronan (Gel-Ph/HA-Ph) hydrogel is used to encapsulate the multicellular spheroids and the constructs are photo-crosslinked using blue light. The results show that Gel-Ph/HA-Ph hydrogels with a 5%-to-0.3% ratio have the best properties. Cells in HBMSC/HUVEC co-spheroids are more favorable for osteogenic differentiation (Runx2, ALP, Col1a1 and OPN) and vascular network formation (CD31+ cells) compared to HBMSC spheroids. In a subcutaneous nude mouse model, the HBMSC/HUVEC co-spheroids showed better performance than HBMSC spheroids in angiogenesis and the development of blood vessels. Overall, this study paves a new way for using nanopatterns, cell coculturing and hydrogel technology for the generation and application of multicellular spheroids.
Investigation of Polymer Aging Mechanisms Using Molecular Simulations: A Review
Authors: Zhang Fan , Yang Rui , Lu Diannan
Published: April 2023

Aging has a serious impact on the properties of functional polymers. Therefore, it is necessary to study the aging mechanism to prolong the service and storage life of polymer-based devices and materials. Due to the limitations of traditional experimental methods, more and more studies have adopted molecular simulations to analyze the intrinsic mechanisms of aging. In this paper, recent advances in molecular simulations of the aging of polymers and their composites are reviewed. The characteristics and applications of commonly used simulation methods in the study of the aging mechanisms (traditional molecular dynamics simulation, quantum mechanics, and reactive molecular dynamics simulation) are outlined. The current simulation research progress of physical aging, aging under mechanical stress, thermal aging, hydrothermal aging, thermo-oxidative aging, electric aging, aging under high-energy particle impact, and radiation aging is introduced in detail. Finally, the current research status of the aging simulations of polymers and their composites is summarized, and the future development trend has been prospected.
Substance Use and Its Association with Risky Sexual Behaviour among Indian Men: A Relative Risk Analysis from Socio-Demographic and Economic Groups
Authors: Das Partha , Das Tanu , Roy Tamal Basu
Published: April 2023

Engagement in risky sexual behaviour after consuming different substances is more prevalent among Indian men. Sometimes, practicing risky sexual behaviour increases the risk of sexually transmitted diseases (STDs), including HIV, among individuals. Around 6 percent of the adult Indian population are diagnosed with STDs every year. Thus, the chief purpose of this study was to investigate the association between the use of substances and engagement in risky sexual behaviour. Descriptive statistics, Pearson’s chi-square test of association, and multivariate binary logistic regression models were performed in this present study by using the data obtained from the NFHS-5 (2019–2021). The results showed that respondents who consumed alcohol were more likely to engage in extramarital sexual affairs (AOR: 1.94; 95% CI: 1.79–2.09; p < 0.001) and sexual intercourse without any precautions (AOR: 1.23; 95% CI: 1.17–1.29; p < 0.001). Poor socio-economic conditions and low levels of educational attainment were found as crucial factors for involvement in risky sexual behaviour. Increasing awareness among individuals through mass media may be considered an effective way to prevent risky sexual behaviour.