bluuebunny/crossref_metadata_2025 huggingface dataset:
Potential predictive marker of treatment effectiveness in patients with osteopenic syndrome after surgical menopause
Authors: Zaydieva Yansiiat Z. , Kruchinina Elena V. , Gorenkova Olga S. , Polyakova Elena Yu. , Kareva Elena N. , Kurguzova Daria O. , Kochina Natalya A. , Krasnoshchok Katherine V. , Serebrova Svetlana Yu.
Published: September 2020

Introduction. Patients with surgical menopause have a risk for osteopenic syndrome (OS). Menopausal hormone therapy (MHT) in combination with calcium and vitamin D promotes increase in bone mineral density (BMD). The expression level of vitamin D receptor in mononuclear fraction cells (MNFC) of blood can be considered as a predictive marker of effectiveness of OS therapy.
Aim. To search a molecular predictive marker of the effectiveness of OS treatment.
Materials and methods. The study included 100 women aged 4055 years with a duration of surgical menopause from 12 months to 6 years. The criterion for including patients in the study was the absence of contraindications to the use of MHT. The subject of the study was the determination of BMD by dual-energy X-ray absorptiometry, polymerase chain reaction diagnostics of the level of expression of vitamin D genes, estradiol and progesterone receptors, determination of 25-OH vitamin D in the blood.
Results. Analysis of 12-month OS therapy effectiveness evaluated with a surrogate marker BMD. The increase in BMD up to 34% per year was treated as absence of negative dynamics, more than 4% per year as positive one. Significant effect of combination therapy compared with MHT on BMD in patients with surgical menopause with a low baseline level of BMD (due to hypovitaminosis D) is associated with the anti-inflammatory, bone-protective effect of vitamin D. In both groups of patients not responding; to the prescribed therapy we were able to conduct a comparative analysis of expression level of the target molecules in the MNFC before the start of treatment. The efficacy of MHT and combination therapy for BMD disorders is positively associated with the expression level of vitamin D receptors in MNFC before treatment. Therefore, the vitDR mRNA level is a potential predictive marker of the effectiveness of OS treatment. The expression levels of nuclear estradiol beta receptor and membrane receptor for progesterone in MNFC before treatment showed an upward trend in women responding to therapy.
Conclusion. The expression level of the vitamin D receptor in MNFC of blood is significantly lower in the group of women with no/insufficient effect on 12-month combined therapy. This indicator can be considered as a predictive marker of the effectiveness of OS therapy.
Recurrent cystitis and bacterial vaginosis: how to avoid polypharmacy
Authors: Kulchavenya Ekaterina V. , Breusoff Aleksandr A.
Published: September 2020

Background. The structure of lower urinary tract infections has clear sex-based differences. The vaginal microbiota is a key factor in the pathogenesis of lower urinary tract infections: aerobic vaginitis predisposes to infection and increases the incidence of cystitis by 2.9 times.
Aim. To determine the effectiveness of Nifuratel as monotherapy in patients with chronic cystitis and concomitant bacterial vaginosis (BV).
Materials and methods. Study design: an open-label, non-comparative, pilot, single-center, prospective study, which included 23 patients with recurrent cystitis and BV. All women received monotherapy with Nifuratel (Macmiror manufactured by Doppel Farmaceutici S.r.l., Italy) in tablets of 200 mg 3 times a day for 7 days. Control visits were performed in 7.90 and 180 days.
Results. BV was diagnosed in all patients; 19 (82.6%) women also had vaginal candidiasis. At the end of therapy, 17 (73.9%) patients showed an excellent outcome, 4 (17.4%) a significant improvement, 2 (8.7%) no effect. After the end of three-month therapy, 18 (81.8%) out of 22 patients who left in the study had no complaints of urinary disorders or vaginal discharge. Their urinalyses were normal. Molecular genetic analysis of the vaginal biocenosis showed moderate dysbiosis; Candida spp. was revealed only in 3 (13.6%) cases. 18 patients came for the 4th visit. Within six months after the end of monotherapy with Nifuratel, the patients had no complaints. They all achieved the recovery of vaginal normocenosis with a sufficient amount of Lactobacillus spp.
Conclusion. Monotherapy in patients with recurrent cystitis and BV is highly effective for both diseases: 73.9% of women achieved stable normalization of urine and vaginal microbiota analyzes, removal of bacteriuria. The bi-directional action of Nifuratel allows to avoid polypharmacy in this category of patients.
Possibilities of using neodymium laser (Nd:YAG) in patients with concomitant diseases which are accompanied by pathological discharge from the genital tract
Authors: Pauzina Olga A. , Apolikhina Inna A. , Malyshkina Darya A.
Published: September 2020

Background. Pathological vaginal discharge is the most common disorder in women after giving birth who have vaginal relaxation syndrome and vaginal wall prolapse, as well as in women during menopause. To date, there are no clear treatment regimens for mixed vulvovaginal infections, and the use of only drug therapy in patients with pelvic organ prolapse and genitourinary syndrome of menopause in combination with diseases which are accompanied by pathological vaginal discharge does not give a long lasting result and is characterized by frequent relapses. In this regard, the use of laser methods in combination with drug therapy may lead to the recovery of vaginal microbiocenosis and a decrease in the number of relapses of diseases which are accompanied by pathological discharge from the genital tract.

Results. Description. This article presents a clinical case and description of the experience of using a neodymium laser for the treatment of a patient with recurrent mixed vulvovaginitis, 2nd- degree vaginal wall prolapse, loss of pelvic floor muscle tone, vaginal relaxation syndrome and sexual dysfunction using neodymium laser. The woman received 3 procedures of exposure to a neodymium laser with an interval of 2830 days. After 3 procedures of exposure to a neodymium laser, the patient has a good clinical efficacy in the recovery of vaginal microbiocenosis.

Conclusions. An innovative technique of exposure to Nd:YAG neodymium laser in the practice of a gynecologist has shown high clinical efficiency in the treatment of not only pelvic floor dysfunction, but also mixed vulvovaginitis. And, despite this aspect of the use of laser technologies requires further study, we can use a neodymium laser in combination with traditional drug therapy to treat diseases which are accompanied by pathological discharge from the genital tract in cases of ineffective drug monotherapy and frequent relapses.
Use of a drug containing ornidazole-neomycin–prednisolone–econazole for the empirical treatment of vaginal infections
Authors: Volkov Valerii G. , Zakharova Tatyana V.
Published: September 2020

Relevance. Empirical treatment of vaginitis is indicated due to its polymicrobial etiology and limited microbiological analysis. The aim of the study was to study the combination of ornidazoleneomycinprednisoloneeconazole (ONPE, Elzhina) as a first-line drug for local treatment of patients with various forms of non-specific vaginitis.
Materials and methods. The study included 55 non-pregnant women aged 18 to 50 years (381.5 years) who had clinical and laboratory signs of acute vaginitis.
Results. All patients at the initial treatment complained of pathological discharge, 47 (85.5%) noted itching, burning, pain in the genital area of various degrees of severity, 17 (30.9%) discomfort when urinating, 9 (16.4%) unpleasant smell, 8 (14.5%) dyspareunia, 4 (2.2%) complained of sensations of a foreign body in the vagina. The clinical and laboratory effectiveness of treatment was 89.1% (49). In 6 (10.9%) patients, clinical improvement was noted, with the remaining laboratory signs of aerobic vaginitis.
Conclusion. The new combination of ornidazoleneomycinprednisoloneeconazole (ONPE, Elzhina ) has a good efficacy and safety profile and can be used to initiate empirical treatment of non-specific inflammatory diseases of the lower genital tract.
Experience in the treatment of chronic endometritis
Authors: Tapilskaya N. I. , Savicheva Alevtina M. , Shalepo Kira V. , Kopylova Anastasiya A.
Published: September 2020

At present, bacterial biofilms play a significant role in chronic endometritis. In our clinical case, a patient with a history of infertility has had no sex life for several years, but bacterial vaginosis recurs monthly. Ascending bacterial infection with chronic endometritis was confirmed by immunohistochemistry data (detection of CD138), as well as microbiological data (detection of anaerobic microorganisms, including Gardnerella vaginalis and Atopobium vagine, in the endometrium). To treat chronic endometritis, we used antibiotic moxifloxacin, followed by administration of bovhyaluronidase azoximer (Longidaza) in the form of rectal suppositories. As a result of complex therapy, the patients endometrium improved (CD138 and anaerobic bacteria revealed), subsequent repeated insemination with donor sperm led to the onset of progressive pregnancy.
Association between deleterious oral habits and its effect on dentition among 5-15 years children
Authors: Reshma T  , Mahesh R  , Balaji Ganesh S
Published: September 2020

Oral habits in children is considered to be one of the most common etiology for orthodontic malocclusion, the prolonged effect of these habits can result in alternation of orofacial structures. Habits are acquired by automatism, represented by an altered pattern of muscle contraction with complex characteristics. In very young children some habits are considered to be a normal process of development at least till 3yrs of age. Oral habits could be parafunctional or functional. It has been observed that there has been an ascending trend in the prevalence of oral habit in children. Thus the aim of this study is to determine the effects of oral habits on dentition. Completed case sheets were collected from a private dental college. Case sheets were taken from June 2019 to April 2020. Data was retrieved and evaluated by 2 reviewers. Once the data was collected, it was then tabulated based on the parameters which are habits, molar relation, malocclusion, age and gender. Correlations between the parameters are determined. The study showed that a total of 50 children ages from 5-15 years old had oral habits. Tongue thrusting was found to be the most common oral habit (44%) Class II Div I malocclusion was mostly seen in thumb sucking patients (31,6%). The 9 year old children were found to be the highest number of children with oral habits. In this study, we observed that children with habits may result in malocclusion if they persist with the habit.
ADMINISTRATIVE SANCTION IN ENVIRONMENTAL LAW
Authors: Bachrul Amiq H.
Published: September 2020

Enforcement of administrative sanctions is part of the enforcement of administrative environmental laws. Law enforcement of the administrative environment itself can be done in a preventive and repressive manner. Administrative law enforcement that is preventive is done through supervision, while repressive law enforcement is done through the application of administrative sanctions. Supervision and application of administrative sanctions aims to achieve the adherence of the public to the legal norms of the administrative environment. Good supervision as part of preventive environmental law enforcement will prevent the violation of administrative law norms. Thus, environmental pollution resulting from such breaches can be avoided. This is better than the enforcement of repressive administrative sanctions after the offense. However, it does not mean that the review of enforcement of administrative sanctions is unimportant.
INTRODUCTION OF AGRICULTURAL CROP RESIDUES AS SUPPLEMENT FOR GOATS FATTENING AMONG ANIMAL REARERS IN GIPALMA MUBI-SOUTH, ADAMAWA STATE
Authors: Babale  , Aliyu A. , Dazala  , Wazamda
Published: September 2020

Fattening has been defined as intensive feeding of highly nutritious feed to and promotes fast growth and fat deposition to achieve desired carcass growth and quality. The main strategy is to fatten young, lean male goat to obtain either from the farmer’s own flock or more often, purchased on the open market over a period of two to three months, with each farmer fattening between one and five animals. The goats are usually tethered or kept in a small sheltered enclosure at the homestead, and often fed and watered individually. Basal feeds used for goat fattening, such as hay and millet straw are supplemented with cowpea haulms, maize bran, rice bran and coconut flour which is derived from the crop residues. Poor nutrition is a major constraint in fattening small ruminants in Nigeria, this is because farmers often give the animals whatever is available, leading to waste when feed availability is high, and underfeeding when it is low (feed availability). Fattening of small ruminants as a business is very common in Nigeria. Small ruminants are usually reproduced on the farms or houses and are sold around festivities. (Christmas and Sallah) or when cash is required. No special efforts, other than grazing the animals, are made by many smallholder farmers and pastoralists to ‘’fatten’’ them. A similar situation exists for fattening of large ruminants (bulls) as a business. Most farmers in Nigeria sell their bulls once they have been introduced to ‘’fatten’’ these animals commercially. Goats are able to subsist and make appreciable gains in long dry season with crop residue-based diets that compare favourably with conventional concentrate rations. Some of the crop residues and by-products available are potentially good feed resources which degrade readily in the rumen, some however, have shown poor degradability and hence, require some treatments before they can contribute to animal nutrition.
AGRICULTURE: PROBLEMS AND SUGGESTIONS OF SATHANKULAM TALUK - TUTICORIN DISTRICT
Authors: Esakkiammal M.
Published: September 2020

Agriculture is one of the most important pillars of the Indian economy. The contribution of agriculture and its allied sectors to India’s GDP stood at 13.9% during 2013-14. More than half of the Indian population is dependent on agriculture for its subsistence. Since the beginning years of economic development, it has been one of the main drivers of growth of the economy as it supplies was a major source of raw materials to most of the manufacturers.  This paper focuses on exploring the socio-economic status of farmer in Tuticorin District, to draw findings, suggestion and conclusion.
DWT - SVD BASED MULTIPLE IMAGE WATERMARKING PROCESSES ON CLOUD COMPUTING
Authors: Ananth C. , Karthikeyan M. , Mohananthini N.
Published: September 2020

In the present work, the multiple watermarking techniques have been executed to present information security. DWT - SVD based multiple watermarking for color images are proposed and has been implemented in cloud computing. The multiple watermarking is used to share the copyright of multiple users improves the robustness and high security. In the proposed work, multiple watermarks are embedded into the cover image. Image quality is computed using Normalized Correlation (NC) and Peak Signal to Noise Ratio (PSNR) for color images. The proposed scheme provides a secure and well imperceptibility to different image processing attacks.
SOCIAL CAPITAL CLASSIFICATION OF SEAWEED CULTIVATORS (CASE STUDY IN LIYA MAWI VILLAGE, SOUTH WANGI-WANGI DISTRICT IN WAKATOBI REGENCY, INDONESIA)
Authors: Fausayana Ine , Nalefo La , Fika Samsul Alam , Ani Dian Aris
Published: September 2020

Social capital plays a vital role in a business as so does in seaweed cultivation. The aims of this study are to know the social capital of cultivators and to analyze the relation of social capital toward business successfulness of seaweed cultivators in Liya Mawi village. The variable of the study is social capital, such as trust, network, and norm; and business achievement based on sales volume and income. This study used the descriptive analysis and correlation test with rank spearman correlation test. The result of this study showed that the social capital of seaweed cultivators in Liya Mawi village are in the medium category to high at around 44.68% have medium level of trust and 55.32% have a high trust level and there is no respondents who have a level of low trust category; Networking category is as high as 42.55% and 57.45%, and there are no farmers are included in the category of low network; and the level of compliance with the norm being as much as 23.40% and a high level of norms compliance as much as 76.60%, while for the low category does not exist. The results of data analysis showed that social capital has a relationship with the level of success of the venture, while the views of the elements of social capital, only the network level that has a relationship with the level of business successfulness.
Period of the day and food-based enrichment affect behaviour activity of Tamandua tetradactyla in captivity?
Authors: Neto Gilson de Souza Ferreira , Barros Adamo Cardoso , Sobroza Tainara Venturini , Neves Pedro Ubatan Camargo , Phillips Matthew J. , Guimarães Elizabeth Ferreira
Published: September 2020

Animais resgatados passam um período em cativeiro antes de serem devolvidos a natureza.  Durante esse período em cativeiro é fundamental que os animais apresentem os comportamentos mais próximos dos apresentados na natureza, e enriquecimento ambiental é uma forma de assegurar o bem estar animal em cativeiro. O objetivo deste estudo foi i) descrever o repertório comportamental de indivíduos do tamanduá-mirim (Tamandua tetradactyla) (Ordem Pilosa), e determinar qual comportamento foi mais frequente; ii) avaliar o efeito do período diurno (06:00–18:00) e noturno (18:00–05:59) na frequência dos comportamentos, e iii) comparar a porcentagem de comportamentos com e sem enriquecimento ambiental. Observações foram feitas utilizando o método de animal focal. Cinco machos e uma fêmea foram observados em pares para se observar as interações entre os indivíduos. Foram registrados 30 atos comportamentais distribuídos em seis categorias: locomoção, forrageio, alimentação, inatividade, limpeza corporal e interação. Geralmente, os comportamentos mais frequentemente observados foram locomoção e alimentação, geralmente durante o dia, exceto inatividade, que foi mais comum durante a noite.  Esse resultado pode ser atribuído a maior atividade diurna do macho, enquanto as fêmeas são mais noturnas em cativeiro. Nossos resultados sugerem que o enriquecimento ambiental favorece maior bem-estar para os indivíduos em cativeiro através do aumento de comportamentos ativos como alimentação, interação e forrageio. Esse estudo provê uma lista de comportamentos que podem ser úteis em entender a etologia e aspectos relacionados à conservação, especialmente em cativeiro de T. tetradactyla.

Palavras chave: Enriquecimento ambiental, tamanduá-mirim, repertório comportamental, animal focal.
Actinomyces in Tonsillectomy Materials
Authors: GÜNİZİ Özlem Ceren , GÜNİZİ Hüseyin
Published: September 2020

Aim: Tonsillectomy is one of the most common surgeries in the pediatric age group. Actinomyces species are Gram-positive, non-spore-forming facultative anaerobic bacteria. Actinomycosis is a disease characterized by abscess formation, ranging from subacute to chronic infection.
Materials and methods: We studied with the tonsillectomy materials of 185 patients who underwent tonsillectomy in our clinic between January 2016 and January 2019.
Results: A total of 185 patients, 98 (53%) males and 87 (47%) females, who underwent tonsillectomy were included in the study. The mean age was 12.6 (range, 3-56) years. A total of 64 patients showed the presence of Actinomyces.
Conclusion: Actinomyces species are bacteria found in the tonsil tissue flora that cause opportunistic infection. Tonsillar Actinomyces colonization is more common in adults and in older children.
Pemanfaatan Handle Grinder Sebagai Mesin Pencacah Pakan Ternak Multi Fungsi
Authors: Basuki Bambang Minto , Robbi Nur
Published: September 2020

Masyarakat Desa babadan yang berada di Kecamatan Ngrambe Kab, Ngawi memiliki warga yang 90 % bermatapencaharian petani dan pekebun. Selain itu mereka juga memiliki usaha tambaan berupa beternak sapi, kambing, kelinci, entok dan bebek. Dalam penyediaan pakan ternak, mereka menggunakan bahan tambahan berupa ubi jalar, batang pisang dan aneka bahan lain yang harus dicacah halus. Hal ini membutuhkan waktu yang lama berkisar 1-1,5 jam tiap harinya. Untuk itu perlu dibantu dengan pemanfaatan mesin cacah pakan ternak yang berkemampuan tinggi dan berdaya listrik rendah. Dengan memanfaatkan handle grinder sebagai penggerak mesin pencacah maka dperoleh hasil yang diharapkan berupa mesin pencacah pakan ternak dengan hasil cacahan yang halus dan membutuhkan waktu kerja yang singkat berkisar 5-10 menit per hari.
Pendampingan Jama’ah Yasinta dan Pengajian Nurul Hidayah melalui Mauidloh Hasanah untuk Mengubah Mindset Konservatif Warga Desa Jegulo Kecamatan Soko Kabupaten Tuban
Authors: Rinwanto Rinwanto , Fransisca Malia
Published: September 2020

YASINTA dan Pengajian Nurul Hidayah merupakan organisasi keagamaan yang rutin dilakukan oleh warga Desa Jegulo Kecamatan Soko Kabupaten Tuban tiap satu minggu sekali. Mayoritas jama’ah YASINTA dan Pengajian Nurul Hidayah adalah warga Desa Jegulo RT. 14 yang sudah berusia di atas 45 tahun. Hal ini berdampak pada pelaksanaan kegiatan rutin tersebut hanya sebatas melanjutkan aktifitas warisan warga terdahulu, tanpa adanya pemikiran-pemikiran untuk mengadakan kegiatan baru yang inovatif dan inspiratif. Oleh karena itu, peneliti menganggap perlu adanya pendampingan supaya kegiatan rutinan tersebut lebih bermakna. Penelitian pengabdian ini menggunakan metode PRA (Participatory Rural Appraisal) dengan pendekatan mauidloh hasanah. Dalam hal ini, peneliti bekerja sama dengan beberapa pengurus YASINTA dan Pengajian Nurul Hidayah untuk mengagendakan kegiatan yang mampu menambah wawasan keagamaan warga Desa Jegulo dengan mengundang orang yang ahli dalam bidangnya yaitu kyai atau ustadh untuk memberikan taushiyah setiap satu minggu sekali. Hasil dari penelitian pengabdian ini adalah setelah adanya stimulus keagamaan melalui mauidloh hasanah, 75% warga Desa Jegulo mengubah mindsetnya menjadi lebih baik. Warga Desa Jegulo RT. 14 berlomba-lomba dalam kebaikan seperti semangat bergotong royong, bersikap lebih terbuka dan memiliki wawasan yang luas juga modern.
Peningkatan Kemampuan Membuat Kuis Online Guru Madrasah Ibtidaiyah (MI) Nurul Islam Wonokalang Wonoayu Sidoarjo melalui Pelatihan Aplikasi Kuis Interaktif Berbasis Quizizz
Authors: Murni Arie Widya , Noviyanti Masyitah , Utami Athika Dwi Wiji
Published: September 2020

Telah dilakukan kegiatan pengabdian kepada masyarakat dengan judul pelatihan penggunaan aplikasi quizizz bagi guru MI Nurul Islam Wonokalang Wonoayu Sidoarjo. Kegiatan ini berlangsung selama dua hari bertempat di ruang aula MI MI Nurul Islam Wonokalang Wonoayu. Tujuan dari kegiatan ini adalah memberikan wawasan pengetahuan dan keterampilan terkait dengan pembuatan kuis menggunakan aplikasi quizizz. Sasaran kegiatan ini adalah semua guru kelas I s.d VI MI Nurul Islam Wonokalang Wonoayu Sidoarjo sejumlah 12 orang peserta. Metode yang digunakan dalam kegiatan pengabdian ini adalah metode pengarahan, diskusi, tanya jawab, praktik secara langsung di lapangan, dan pendampingan. Para peserta sangat antusias mengikuti kegiatan ini karena sebagian besar guru belum pernah membuat kuis menggunakan aplikasi quizizz. Setelah mengikuti kegiatan ini para peserta diharapkan dapat membuat kuis sesuai dengan materi yang diajarkan pada peserta didik.
Проблеми стандартизації аеродромно- технічного забезпечення державної авіації України та шляхи їх вирішення в умовах взаємодії з НАТО та міжнародної інтеграції
Authors: Новічонок С.М. , Бабіч О.В. , Терентьєва І.В.
Published: September 2020

В статті проведений аналіз законодавчих документів України та іноземних держав, щодо аеродромно-технічного забезпечення (АТЗ) літальних апаратів та аеродромів. Наведені організаційні заходи за допомогою яких, можна мінімізувати брак транспортної авіації під час перевезень габаритних та негабаритних вантажів. В статті наведені дані, щодо інцидентів пов’язаних з наземним обслуговуванням повітряних суден (ПС), вказані причини подій під час АТЗ та наведена схема розташування спеціальних транспортних засобів наземного обслуговування, їх під’їзд та від’їзд від літака, щоб наглядно проілюструвати складність обслуговування ПС. На основі проведеного аналізу визначені основні шляхи усунення проблем стандартизації АТЗ в умовах взаємодії з НАТО та в процесі міжнародної інтеграції. Запропоновано використання методів системного аналізу та моделювання для обґрунтування конкретних заходів по удосконаленню процесів наземного обслуговування.
Обґрунтування показників якості прийнятих рішень на основі оцінки вихідних даних
Authors: Орлов С.В. , Авілов А.І.
Published: September 2020

У статті розглядаються підходи до обґрунтування показників якості прийнятих рішень на основі оцінки вихідних даних. Процес прийняття рішень з управління військами і зброєю ґрунтується на обробці інформації, що надходить від різних джерел за видами забезпечення. У процесі обробки інформації розробляються цілком певні документи за відповідними напрямами діяльності військ. Інформація від кожного джерела із заданою періодичністю оновлюється. Повнота і обґрунтованість прийнятих рішень безпосередньо залежать від якості інформації, що надходить. Пропонується оцінювати якість інформації, на основі якої приймаються рішення з управління військами і зброєю, через невизначеність повноти поновлення інформації, що надходить від відповідних джерел. З урахуванням нечутливості ентропії до випадків, коли використовується явно застаріла інформація, або ж навпаки, практично своєчасно оновлена, вводиться показник який враховує своєчасність оновлення інформації і реальний час вироблення рішень бойовим розрахунком пункту управління. Введений показник дозволяє оцінити використовувані інформаційні ресурси в даному процесі, їх повноту і своєчасність подання на пункт управління.
Визначення критеріїв оцінювання стану метрологічного забезпечення зразків озброєння та військової техніки за військову частину
Authors: Бурцева В.В.
Published: September 2020

Розглядаються питання оцінювання метрологічного забезпечення у процесі перевірки стану озброєння та військової техніки (далі – ОВТ) за військову частину, під час контролю боєздатності та мобілізаційної готовності й визначення спроможності виконання завдань за призначенням. Досліджується діючий порядок оцінювання стану метрологічного забезпечення зразків ОВТ за військову частину, що здійснюється у процесі перевірки їх стану, та визначаються некоректності, що призводить до неоднозначності під час визначення оцінок. Обґрунтовуються кількісні значення показників (критерії) оцінювання стану метрологічного забезпечення зразків ОВТ за військову частину, які дозволяють: усунути неоднозначність під час визначення оцінки за метрологічне забезпечення зразків ОВТ за військову частину; кількісно оцінювати ефективність заходів метрологічного забезпечення зразків ОВТ під час оцінювання стану озброєння та військової техніки військових частин та встановити порівняльну ранговість повноти виконання заходів з метрологічного забезпечення військовим частинами.
Методика визначення оптимального розміщення виїзних метрологічних підрозділів на прикладі проведення операції Об’єднаних сил
Authors: Войтенко С.С. , Бабич О.О. , Мошаренков В.В.
Published: September 2020

При проведенні операції Об’єднаних сил (задіяні різні силові структури) однією з проблем є оптимізація системи метрологічного забезпечення силових структур. Актуальним науковим завданням цієї складної проблеми є оптимізація розміщення виїзних метрологічних підрозділів для метрологічного обслуговування ОВТ цих силових структур. Метою статті є розробка методики визначення оптимального територіального розміщення метрологічних підрозділів для відновлення засобів вимірювальної техніки, зі складу ОВТ силових структур, задіяних в проведенні операції об’єднаних сил. Розроблена методика визначення оптимального розміщення виїзних метрологічних підрозділів. На базі методу неявного перебору. Запропонована методика дозволяє скоротити кількість можливих варіантів розміщення без втрати оптимального рішення та надає можливість економити час при плануванні діяльності цих груп.
Обґрунтування вибору матеріалів п’єзодатчиків для виконання завдання захисту території охороняємих об’єктів
Authors: Нікіфоров М.М. , Пампуха І.В. , Ільченко В.В. , Кульський О.Л.
Published: September 2020

В роботі проведено аналіз оптимального вибору сейсмодатчиків, призначених для охорони території військових об’єктів та здатних працювати в складних природних умовах. Встановлено, що для виконання задач охорони периметру військових об’єктів за своїми характеристиками найбільш підходять сейсмоакустичні засоби виявлення, принцип дії яких заснований на п’єзоефектах, або їх гнучка конфігурація з іншими засобами охорони. Досліджені основні параметри п’єзоелементів загальноприйнятих в п’єзотехніці та визначені оптимальні співвідношення констант п’єзокерамічного матеріалу, з якого виготовлено п’єзоелемент, що впливає на основні електрофізичні властивості п’єзодатчика. Надано висновок, що при проектуванні п’єзодатчиків на п’єзокерамічних матеріалах правильний вибір матеріалу є визначальним фактором щодо визначення оптимальних властивостей сейсмоприймачів з найкращими характеристиками (підвищений точності, стабільності, чутливості, розширення робочого діапазону частот та ін.).
Сутність, зміст та оцінка ефективності управління підрозділом протиповітряної оборони Сухопутних військ та вогнем в бою
Authors: Лезік О.В. , Волков А.Ф. , Токар О.А. , Стадніченко В.Г.
Published: September 2020

Розглядаються основні питання стосовно сутності та змісту управління, основ оцінки ефективності управління з метою вирішення певних  завдань, а також можливості системи управління та визначаються  основні фактори, від яких залежать можливості системи управління. Також визначений критерій ефективності та розроблені пропозиції  щодо підвищення ефективності управління підрозділом ППО СВ та вогнем в бою в різних умовах обстановки. Дані положення можуть бути використані для підвищення ефективності навчання курсантів факультету та тих, що навчаються на курсах підвищення кваліфікації, вдосконалення навчального процесу підготовки спеціалістів факультету, а також якості підготовки спеціалістів за фахом.
In Vivo Curative and Antacid Effects of Cameroonian Clay (MY41g) on Chronic and “Unhealed" Gastric Ulcers in Rats
Authors: Emakoua Joseph Fleurie , Siwe Tchokomeni Gael , Tan Paul Vernyuy , Amang Andre Perfusion , Banenzoue Charle , Mezui Christophe , Enow-Orock George Enonchong
Published: September 2020

This study evaluated the in vivo curative and antacid effects of MY41g clay on chronic and “unhealed" gastric ulcers in rats. Chronic gastric ulcers were induced by injecting 0.05 mL of acetic acid (30%) into the stomach wall. From day 5-14 after induction of ulcers, rats were treated daily with MY41g clay (125 and 250 mg/kg). For “Unhealed" gastric ulcers, from day 5-18 rats received MY41g clay orally concomitantly with indomethacin (1 mg/kg/day) subcutaneously. The ulcer index, percentage of healing, mucus secretion, histological parameters, oxidative stress parameters and gastric acidity were assessed. Treatment with clay solution for 10 days resulted in accelerated spontaneous healing of chronic gastric ulcers (83.69-90.2%). However, indomethacin administration did not induce significant variations in the percentage of healing (89.23-91.66%) in rats. For both ulcer models performed, ulcer healing was accompanied by a significant increase (p<0.001) of mucus secretion at the highest dose. Clay increased concentrations of antioxidant enzymes and decreased gastric acidity and lipid peroxidation. Administration of clay accelerated the spontaneous healing of both induction models. The mode of action of the clay could involve increased gastric mucus production, gastric mucosal re-epithelialization, improved antioxidant status and gastric acid neutralization. MY41g clay can be used as antacids in the ulcer treatment regime.
First Record of Gracixalus quangi Rowley, Dau, Nguyen, Cao et Nguyen, 2011 (Anura, Rhacophoridae) from China
Authors: Liu Shuo , Rao Dingqi , Li Song
Published: September 2020

We record Gracixalus quangi Rowley, Dau, Nguyen, Cao et Nguyen, 2011 for the first time from China based on fourteen specimens collected from southern Yunnan. Morphologically the newly collected specimens from China mostly agree with the type series from Vietnam. Phylogenetically these individuals were placed in a clade with G. quangi from Vietnam and pairwise genetic distances in DNA sequences of the mitochondrial 16S rRNA gene between these individuals and G. quangi from Vietnam is 0.6%. Our finding brings the species number of the genus Gracixalus to 9 in China.
Weight-gaining medications used by patients followed up at the bariatric and metabolic surgery service of a university hospital
Authors: SOUZA Layse A. , ARAÚJO Allan C. , SILVA Ligiane L. , MENOLLI Poliana S.
Published: September 2020

Objective: To verify an association between weight and use of medications that lead to weight gain (MLGP) in a population of obese patients monitored in the Unified Health System. Methods: This is a retrospective descriptive sectional study with data from medical records of all patients. patients treated by the University Hospital Multiprofessional Service for obese patients who are candidates for bariatric surgery. The collection took place from January 2014 to March 2016. A weight-dependent variable, used in the body mass index (BMI) and degree of obesity and as independent variables of sex, age, education, income, number of diseases, number of drugs and number of MLGP. The association was calculated using the Ro Spearman correlation and the chi-square test. Results: 102 patients were studied, mostly women (87%), with a mean BMI of 45.9 kg / m2 (min 32.56 - maximum 70.98 kg / m2 SD = 6.43). The main comorbidities were systemic arterial hypertension (65.7%) and osteoarticular disorders (39.2%). The average number of drugs per patient was 4.3 and the most used class was for the renin-angiotensin system (67.3%). MLGP corresponds to 10.4% of the drugs used and 27.4% of the patients use them. MLGP patients used an average of 5.8 medications and the most prevalent classes were betablocking agents (60.6%), followed by medications used in diabetes (24.2%). Atenolol and a glibenclamide were the most used MLGP. The mean BMI of patients who used more than one MLGP was 51 kg / m2. Conclusion: There was no correlation between weight and the use of MLGP in this population. However, patients who used the MLGP combination had a higher BMI.
Administration of inhaled medications during noninvasive ventilation and/or tracheostomy
Authors: ASTURIAN Kathleen , FERREIRA Maria A.
Published: September 2020

Objectives: To describe the clinical and demographic profile of hospitalized patients undergoing noinvasive ventilation (NIV) and/or tracheostomy (TQT) with prescription of the pressurized inhaler (pMDI) and the difficulties and interventions performed to adapt the inhalation technique. Methods: This is an observational, retrospective and descriptive study of a series of cases, carried out in three clinical units of a university hospital in the years 2017 and 2018. Results: We analyzed data from 25 patients who received NIV and/or TQT for whom guidance has been requested from the Inhalation Techniques Guidance and Training Group (GOTTI). Of these, 15 patients (60%) were using NIV, 5 (20%) were tracheostomized and 5 (20%) were tracheostomized with NIV. The difficulties identified in these patients were insecurity in removing the support, preference for nebulization, adaptation of the pMDI to the cannula and asynchrony between the jet firing and the beginning of inspiration. Conclusions: The use of aero-chamber coupled to the pMDI and tidal volume were the mostly made interventions. Masks and guidelines on the access route to the ventilation system were adapted in most cases This group of patients has particularities and difficulties in the inhalation technique that justify a specific educational intervention by professionals with more in-depth knowledge in the area.
Factors associated with falls in elderly people with osteopenia or osteoporosis counter-referred from secondary care
Authors: PINHEIRO Fernanda C. , REIS Edna A. , RUAS Cristina M.
Published: September 2020

Objective: Analyze the factors associated with the occurrence of falls in the elderly with low bone mineral density. Methods: Study performed between July 2014 and January 2016. Involved a cross sectional secondary data collection and telephone survey to counterreferred elderly patients from a secondary care service for primary care service in Belo Horizonte, Minas Gerais. Results: Were analyzed data from 2.020 patients and, among them, 1.120 were selected to participation in telephone survey phase. Respondents were predominantly female, aged 70-79 years, with normal or overweight body mass index, diagnosed with osteoporosis and family history of fractures. Regarding habits, the greater proportion did not practice physical activities, did not drink and smoke, did not sunbathe and had low intake of dark green vegetables. In addition, most of them had a fixed income, had been contacted by primary care after counterreferral and depended exclusively on the National Unified Health System. Higher proportion of falls was observed among women, in patients diagnosed with osteoporosis, with advanced age, who did not receive contact to return to the health center and in those with individual and family history of fractures. Statistical analysis demonstrate female gender, advanced age, individual or family history of fractures and low or no intake of dark green vegetables were factors that increased the risk of falls. Conclusion: Recommendations for improving health habits are simple actions and should be encouraged because they contribute to reducing the occurrence of falls and, consequently, it may lead to decrease morbidity and mortality of elderly patients.
Quality of life evaluation of coinfected patients with HIV/tuberculosis in a hospital in northeast Brazil
Authors: SILVA Amanda D. , AMORIM Thaylany C. , ARAGÃO Ádeny M. , IBAÑEZ Maria J. , FILHO José A. , SILVA Rosali M.
Published: September 2020

Objectives: To evaluate the quality of life of patients coinfected with HIV/tuberculosis and to understand their perception of their health. Methods: A cross-sectional study was carried out in a hospital in the state of Pernambuco, Brazil. Data were collected between November 2017 and April 2018 through interviews. The WHOQOL-HIV Bref instrument was used, obtaining the total score and performance in the domains: physical, psychological, level of independence, social relationships, environment, spirituality. Sociodemographic and clinical data from the Logistic Control System of Medicines (SICLOM®) were also collected through a questionnaire. Results: Twenty-six patients were interviewed, 76.9% were male, mostly heterosexual, single, 43.1% presented an advanced state of immune system compromise. 73.1% considered their health "good" or "very good" and 69.2% did not consider themselves sick. The general quality of life, score from zero (worst quality of life) to one hundred (best quality of life) obtained an average of 69.6 ± 9.1. In the domains, the worst average was obtained at the independence level (11.1 ± 2.6) and the highest scores were in the spirituality (15.5 ± 3.8) and psychological (15.3 ± 2.2) domains. Conclusions: The low level of independence and the unfavorable socioeconomic conditions were important aspects influencing in the quality of life of the studied population. Knowledge about the most affected domains in the quality of life allows the elaboration of clinical guidelines and public assistance policies that contribute to the well-being of these patients.
Identification of anticholinergic activity of drugs of the Brazilian National List of Essential Drugs
Authors: LIMA Mariana S. , REIS Adriano M.
Published: September 2020

Objectives: Identify drugs from the National List of Essential Medicines-Rename 2018 that have anticholinergic activity and scales of anticholinergic activity available for use in clinical practice. Methods: Drug utilization study, emphasizing the analysis of supply. The drugs included in Brazilian National List of Essential Drugs (BNLED) 2018 were classified according to level 3 of the chemical therapeutic anatomical classification. A literature review was performed to identify anticholinergic activity measurement scales. Anticholinergic activity of BNLED 2018 drugs was determined using the Composite anticholinergic scale. Results: It was identified two systematic reviews, among the 13 identified scales, Duran's Scale and Composite Anticholinergic Scale. Composite Anticholinergic Scale is the most comprehensive with 197 drugs. It was found that 14.6% of the drugs have anticholinergic activity and 69.1% are included in the basic component of the national list. Drugs with central nervous system activity constitute about 50% of the substances with anticholinergic activity, mainly comprised of antipsychotics, followed by cardiovascular system drugs, mostly represented by betablockers. The cumulative effect of anticholinergic activities, from several drugs prescribed concomitantly, reflects the importance of verifying prescriptions and aware health professionals of strategies to reduce this impact. Conclusions: To measure anticholinergic load in clinical practice, 13 scales are available. The most comprehensive scale is the Composite Anticholinergic Scale. Although medicines with anticholinergic activity are uncommon among medicines included in BNLED 2018, it is needed to provide information to prescribers due to the negative clinical outcomes attributed to cumulative anticholinergic burden.
Potential drug interactions and inappropriate medications prescribed for primary health care users
Authors: ROCHA Rafaela S. , SILVA Luanna G. , FERNANDES Máyra R. , FIGUEIREDO Roberta C. , BALDONI André O.
Published: September 2020

Objectives: To analyze potential pharmacological interactions and drugs potentially inappropriate for the elderly in users of primary care of the Unified Health System. Methods: This is a cross-sectional study with individuals aged 18 years or over, who were approached at the health facilities of the city of Divinópolis, MG, at which time a home visit was scheduled. A structured questionnaire on drug use was applied and drug interactions were analyzed in Drugs.com® sources, Micromedex®, bulletin of the Brazilian Health Regulatory Agency (ANVISA). Only the frequencies of serious interactions were analyzed. Potentially inappropriate drugs for elderly people (MPI) were identified by the Beers Criterion (2015) and the Brazilian Consensus on Potentially Inappropriate Medications for the Elderly (2016). The Mann-Whitney test was performed to compare the medians of the analyzed variables. Results: Among the study participants, 55% were elderly. Comparing them with the adult population, it was observed that the number of medications and potential drug interactions were significantly higher (p <0.05) among patients 60 years of age or older. Considering only the elderly, 77.3% used at least one MPI, according to the Beers Criterion. Conclusion: It was found that the vast majority of primary care users use at least one inappropriate drug and, when compared to adults, are more exposed to polypharmacy and potential drug interactions.
Microbiological profile of isolated specimens in patients admitted to a university hospital from Fortaleza, Brazil
Authors: FREIRE Thalita M. , CHAVES Elana F. , ALCÂNTARA-NETO José M. , SOUSA Paulo P. , RODRIGUES Jorge N. , REIS Henry C.
Published: September 2020

Objective: To assess the microbiological profile of culture results of patients admitted in a public university hospital from Fortaleza, Brazil. Methods: This is a descriptive and prospective study with patients being followed up in an antimicrobial stewardship program and in use of reserve or strategic antimicrobial agents, which had cultures requested between May and November 2017. Data was obtained from the patient’s records, registered and analyzed using Excel spreadsheets and Graph Pad Prism statistical software. Results: Male patients (60.2%), non-elderly (63.6%), with hospital discharge clinical outcome (84.7%) and kidney transplant specialty (35.6%) prevailed. We analyzed the result of 490 cultures, with a higher frequency of urine cultures (35.3%) and blood cultures (34.7%) than others cultures. The specialty with most requests was kidney and liver transplant. 19.8% of the cultures were positive, predominantly gram-negative bacilli (72.2%), especially in the urine cultures of transplant patients. Microbiological analysis showed that Klebsiella pneumoniae (49.1%) and Escherichia coli (39.6%) were the bacteria most frequently found. Regarding the microbial resistance profile, we identified carbapenemase producing bacteria (16.7%), Extended spectrum beta-lactamases (ESBL; 33.3%) within the group of gramnegative bacilli and Vancomycin-resistence enterococcus (VRE; 13.5%) within the group of gram-positive cocci. Conclusions: The study enabled the knowledge of the profile of microorganisms isolated in the wards under study, which is of fundamental importance for local epidemiological studies and for the control of microbial resistance.
Description of a Comprehensive Medication Management service in an adult intensive care unit
Authors: SOUZA Igor G. , NASCIMENTO Mariana G. , RAMALHO DE OLIVEIRA Djenane , ARCHONDO Marcia E.
Published: September 2020

Objective: To describe the results of a Comprehensive Medication Management (CMM) service offered to patients of an adult intensive care unit. Methods: A descriptive cross-sectional study of the results of the CMM service (April 2017 to November 2018). All the patients followed up in the CMM service were included in the sample of this study. The service was integrally based on the Pharmaceutical Care Practice and, therefore, used the Pharmacotherapy Workup (PW) method. the drug therapy Problems (DTP) were quantified and classified according to the PW method. The main medications involved in the DTP were also described, as well as the acceptance of the interventions by the multidisciplinary care team members and patients. Results: 146 patients were followed up during the study period, and 512 DTP were identified. Of these DTP, most were related to medication safety (37.7%) and to indication (37.5%). The main causes were high dose (23.0%, with emphasis on dose adjustments in cases of kidney injury), need for additional medication (18.9%, inclusion of medication for electrolytic, glycemic, and prophylactic control), and unnecessary medication (18.6%, emphasis on de-prescription of antibiotics that were not indicated). Most of the problems (23.6%) were related to the therapeutic class of systemic anti-infective agent. Of the total DTP detected, 81.6% were resolved. A total of 451 interventions were implemented, of which 92.9% (n=419) were with physicians. The majority of the interventions with physicians were accepted (n=344, 82.1%). Conclusion: A high number of drug therapy problems have been detected and resolved by the CMM pharmacist, with emphasis on safety problems. The high acceptability of the interventions reinforces the need for the service applied to the critical patient.