bluuebunny/crossref_metadata_2025 huggingface dataset:
Basics and Fundamentals of Natural Product Research
Authors: Chukwuma Michael Onyegbulam , Chidinma Mba Theodora Chidinma , Chikeokwu Ikenna
Published: February 2024

Historical evidence shows that plant-derived agents have had therapeutic relevance in the lives of humans providing different classes of drugs. Many natural products and synthetically modified natural product derivatives have been successfully developed for clinical use to treat human diseases. Drug discovery from medicinal plants continues to provide new and important leads against various pathologies targets including cancer, malaria, cardiovascular diseases and neurological disorders. Proper sample preparation can increase the extraction efficiency of biologically active compounds. Extraction is the separation of the pharmacologically active, chemical distinct non-matrix components of a plant, microbial, or animal material from the matric (structural) parts. Natural extracts are often extremely complex and contain many unknown compounds. In this situation, the use of an effect-related analytical approach is a real relief. Information about biological effects of natural complex materials in humans, is a necessity for natural product research to be meaningful and useful. This brings to the fore effect-directed analysis which identifies or isolates substances of biological relevance. Data bases and books were consulted for information contained in this review. This review discusses the fundamentals of natural product research from a wide range of methods of preparing plant material, extraction, concentration, separation, isolation, pharmacological activity screening, toxicity profiling, virtual screening, and data analysis
Acute and Sub-Chronic Toxicity Profile of Aqueous Fruit Extract of Spondias Purpurea Linn (Anacardiaceae): In Wistar Rats
Authors: Abubakar Ibrahim Abdullahi , Ochuko Helen Kwanashie , Bola Sherifat Anafi , Abubakar Mohammed Mahdi , Oluwaiye Jonah Omonofa
Published: February 2024

This study aimed to investigate the toxicological profile of aqueous fruit extract of Spondias purpurea (AFES) in Wistar rats. The AFES was subjected to preliminary phytochemical screening, acute and sub-chronic toxicity studies which were conducted using standard methods. Sub-chronic (90 days) toxicity studies were carried out on four (4) groups. The first group received distilled water (1 ml/kg). Groups 2, 3 and 4 received AFES (250, 500 and 1,000 mg/kg respectively). The effect of the extract on body weight, relative organ weights, haematological and biochemical (kidney function, liver function and lipid profile) parameters as well as histopathological studies of the organs (liver, kidney, lungs, brain, heart, stomach and testes) was investigated. Preliminary phytochemical screening revealed the presence of alkaloids, cardiac glycosides, flavonoids, saponins, sterols, triterpenes, steroids and tannins. The oral median lethal dose (LD50) was greater than 5,000 mg/kg. Sub-chronic administration of AFES did not produce significant (p > 0.05) changes in body weights, relative organ weights, haematological and biochemical parameters of treated rats. However, there was a significant (p < 0.05) increase in urea at 250 mg/kg, a decrease in sodium ion at 500 and 1,000 mg/kg in a dose-dependent manner and decrease in chloride ion as well as decrease in triglycerides at 1,000 mg/kg treatment groups. Histopathology investigation revealed some levels of damage to the organs; liver, kidney, testis, lung and heart of the extract treated animals. These findings suggest that aqueous fruit extract of S. purpurea is relatively safe on acute administration. However, sub-chronic administration could result in mild toxic effects.
The Role of Preparing Teachers’ Understanding of the Co-Teaching and Collaborative Teaching Models in Developing their Teaching Experiences
Authors: Al-Amrat Mohammad Ghazi Raja
Published: February 2024

This study explored the role of preparing teachers’ understanding of the co-teaching and collaborative teaching models. This research aims to significantly advance inclusive education practices by offering novel perspectives on the functions of co-teaching models and the preparation programs for pre-service teachers. This investigation employed a descriptive research technique to understand the essential elements and strategies of effective preparation programs for pre-service teachers that promote co-teaching and inclusive education, as perceived by teachers. A total of 30 individuals participated in the research project, consisting of 20 pre-service teachers in their last year of college and 10 full-time teachers in public schools in Saudi Arabia. The survey revealed that 80% of the pre-service teachers considered that peer-to-peer learning activities, such as group discussions and collaborative projects, were the most effective means of acquiring knowledge regarding co-teaching approaches. The comprehensive findings of this study challenge conventional notions regarding the preparation of teachers and highlight the urgent necessity of formulating novel and all-encompassing approaches for pre-service teacher training.
Optimization Studies on Catalytic Pyrolysis of Empty Fruit Bunch (EFB) Using L9 Taguchi Orthogonal Array
Authors: Doraiselvan Kirenraj , Yusup Suzana , Kin Wai Cheah , Muda Nur Suriawanie , Gurdeep Singha Haswin Kaur
Published: February 2024

In this investigation, catalytic pyrolysis of empty fruit bunch (EFB) was studied and optimized in terms of bio-oil and char yields by using Taguchi L9 Orthogonal Array method. The effects of pyrolysis temperatures, catalyst loadings and particle sizes on the product yields were investigated and discussed in this paper. The catalytic pyrolysis is performed in a semi-batch reactor which is externally heated by an electrical vertical split tube furnace. Under the nitrogen flow rates of 60 ml/min, 80 ml/min and 100ml/ min, 15g of EFB biomass with the particle sizes of 100 µm, 250 µm, 500 µm were thermally decomposed at three pyrolysis temperatures of 573K, 673K and 773K, along with Zeolite HZSM-5 catalyst loadings of 1 wt%,5 wt% and 12 wt%. From the product analysis, a maximum liquid bio-oil yield of 64.4 wt% were obtained at catalyst loading of 1.5 wt.%, reaction temperature of 773K, nitrogen flow rate of 100 mL/min, and particle size of 250 µm. Meanwhile, at catalyst loading of 3.25 wt.%, reaction temperature of 773K,, nitrogen flow rate of 60 mL/min and particle size of 250 µm, the bio char yield formed was as low as 18.6 wt.% which could be mainly attributed to secondary cracking of char residue. The predicted maximum liquid yield and minimum bio char yield is validated with an experimental run at the corresponding predicted conditions.
A Study to Evaluate the Complications of Laparoscopic Renal and Adrenal Surgeries Using Modified Clavien-Dindo Classification
Authors: Nallabothula Anil Kumar , Nalumaru Anirudh Suseel , Mudunuri Harsha Vardhana Varma , Jayant Ashish Kumar , Bhargava Anupam
Published: February 2024

Background: Laparoscopic surgery has become a widely accepted approach for the treatment of renal and adrenal diseases. However, there is a need to assess the post-operative complications associated with these procedures using standardized classification systems. The modified Clavien-Dindo classification system offers a comprehensive framework for evaluating surgical outcomes and determining the severity of complications. Methods: This prospective study involved 106 patients who underwent laparoscopic renal and adrenal resective surgeries. Post-operative complications were recorded and graded according to the modified Clavien-Dindo classification system. The data collected were analysed to assess the incidence and severity of complications in relation to patient demographics, comorbidities, and surgical procedures. Results: Among the 106 patients, 16.03% experienced post-operative complications, with 13.20% classified as minor complications and 2.83% as major complications. The most common minor complications included delayed bowel movements and wound infection, while major complications included conversion to open surgery and the need for ventilator support or haemodialysis. No deaths were reported in the study. The association between complication rates and age, gender, ASA grade, side of pathology, comorbidities, and pathology/diagnosis was not statistically significant. However, higher grade complications tended to occur more frequently in elderly patients, males, and those with comorbidities. Conclusions: This study supports the effectiveness of laparoscopic surgery for renal and adrenal diseases, as evidenced by low complication rates. The modified Clavien-Dindo classification system proved valuable in assessing and categorizing post-operative complications, enabling a comprehensive evaluation of surgical outcomes. Implementation of this standardized classification system can contribute to improving patient safety and the overall quality of surgical care. Further research with larger sample sizes and longer follow-up periods is recommended to obtain more precise and comprehensive data on long-term morbidity and mortality associated with laparoscopic renal and adrenal resective surgeries.
Isolated Polycystic Disease of the Pancreas
Authors: Patel Vaibhavi P , Vinaykumar Parikh Tirth , Parmar Siddharth S , Chavda Rajveersingh
Published: February 2024

Isolated polycystic disease of the pancreas is an extremely uncommon condition, with very few examples documented in the literature. Pancreatic cystic lesions are usually associated with other genetic disorders that involve other organs as well. However, isolated pancreatic polycystic disease is rare. We reported a symptomatic case of polycystic disease of the pancreas without evidence of cystic lesions in other organs.
ARTIFICIAL INTELLIGENCE IN EYE DISEASE: AN UPDATE SYSTEMATIC REVIEW
Authors: Firmansyah Arwan , Surya Dinajaya I Made , Arfan Muhammad , Utama Arya
Published: February 2024

Background: In recent years, AI has significantly revolutionized the healthcare industry, with deep learning applications being used to identify various illnesses, evaluate cancerous lesions, and determine stroke onset. AI-based systems also have been applied in ophthalmology to address leading eye diseases.
The aim: This study aims to determine the role of artificial intelligence (AI) in eye disease.
Methods: By comparing itself to the standards set by the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) 2020, this study was able to show that it met all of the requirements. So, the experts were able to make sure that the study was as up-to-date as it was possible to be. For this search approach, publications that came out between 2014 and 2024 were taken into account. Several different online reference sources, like Pubmed and ScienceDirect, were used to do this. It was decided not to take into account review pieces, works that had already been published, or works that were only half done.
Results: In the PubMed database, the results of our search brought up 157 articles, whereas the results of our search on ScienceDirect brought up 256 articles. The results of the search conducted by title screening yielded a total of 34 articles for PubMed and 28 articles for ScienceDirect. We compiled a total of 16 papers, 10 of which came from PubMed and 6 of which came from ScienceDirect. We excluded 4 review articles, 2 non-full text articles, 3 articles having insufficient outcomes, and 1 article having ineligible subjects. In the end, we included six research that met the criteria.  
Conclusion: Our systematic study suggests that AI has a role in the diagnosis or screening of eye disease. AI can be a valuable tool for diabetic retinopathy (DR) screening, glaucoma screening, myopia screening, and diagnosis of dry eye syndrome.
RFID BASED SMART SYSTEM FOR STORING DATA
Authors: Krishna, M. , Shivprasad Lingampally , Ravinder S. , Prathibha S.
Published: February 2024

The main functionality of this project is to access the passport details of a passport holder through RFID technology. For this purpose the authorized person is given an RFID card. This card contains an integrated circuit that is used for storing, processing information through modulating and demodulating of the radio frequency signal that is being transmitted. Thus, the data stored in this card is referred as the passport details of the person.Passport verification and checking is a very time consuming process. This proposed system simplifies the process by giving the authorized person an RFID tag containing all the passport details like name, passport number and nationality etc. Once, the person places the cardin front of the RFID card reader, it reads the data and verifies it with that data present in the system and if it matches then it displays the details of the passport holder. Here we use microcontroller from 8051 family. For display a 16X2 LCD is used. The status also can be retrieved from this system by pressing the status button interfaced to a microcontroller.

 

Further the project can be enhanced by using finger printer module. This overcomes thedrawbacks of RFID and provides high level of security in the system.
A COMPREHENSIVE STUDY OF ASSETS MANAGEMENT COMPANY , FOCUSING ON INVESTMENT STRATEGIES, PERFORMANCE, AND REGULATORY.
Authors: Chakradhar G. , Apku Malika , Anusha G. , Madhavedi Dr. Sudhakar
Published: February 2024

Major shifts in the competitive environment encouraged a recent growth in the number of academic articles devoted to strategic aspects of asset management. Organizations start to recognize that a strategic approach to asset management becomes a source of sustainable competitive advantages and long-term survival in the turbulent environment. However, existing studies are largely case-specific in interpreting strategy and draw on various theoretical grounds and approaches. This leads to little theoretical and methodological consistency in understanding current findings and how to design future studies. The key goal of this paper is to systematically review the existing research through the analysis of over 700 articles devoted to asset management with a focus on strategic aspects. Our key contributions are positioning strategic asset management within the vast field of asset management research, describing the nature of strategic asset management research, and confirming that asset management strategies align with different levels of organizational strategy. We visualize the existing research field, and indicate gaps and underdeveloped areas of research. We also shortly outline future research directions based on our findings, thus encouraging a more coherent development of research on strategic asset management.
Assessment of the Impact of PM2.5 Air Pollution on River Dynamics: A Case Study of Daqing, China.
Authors: Bian Jianmin
Published: February 2024

This study aims to explore the causal relationship between air pollution and river flow in Daqing City, specifically focusing on PM2.5 particle concentration. During comprehensive five-year research, a progressive decrease in air quality was seen, shown by a rise in the yearly average PM2.5 concentration from 13.4 µg/m³ to 18.7 µg/m³. This work utilizes hydrological modeling to reveal a strong negative association between the rise in PM2.5 concentration and the decline in river flow. The decline observed can be attributed to variations in solar radiation and surface temperature, which are clearly impacted by pollution. Ecological investigations showed that the decrease in river flow led to severe ecological impacts, including higher water temperature and alterations in nitrogen levels. This study emphasizes the crucial need to implement thorough environmental management strategies to successfully reduce the detrimental effects of air pollution on river ecosystems. This study enhances our comprehension of the intricate connection between air pollution and river dynamics, on both a regional scale and within the wider context of the southern hemisphere. It highlights the worldwide significance of safeguarding clean air and water resources.
MENGGERAKKAN LITERASI LAPORAN KEUANGAN PADA UMKM KELURAHAN TAMBAK SARI KOTA SURABAYA
Authors: Rahmawati Mia Ika , Ardini Lilis , Lestariningsih Marsudi , Shabrie Wiwiek Srikandi
Published: February 2024

Tumbuhnya UMKM dapat menambah penciptaan lapangan pekerjaan, pengurangan pengangguran dan dapat membantu dalam hal pemberantasan kemiskinan masyarakat. Namun saat ini masih banyak UMKM terutama di Kelurahan Tambaksari Kota Surabaya masih terkendala pada hal pengelolan keuangan padahal potensi untuk berkembang sangat besar. Kendala tersebut sebenarnya bisa diantisipasi dengan adanya merubah UMKM menjadi bankable dimana UMKM harus menyediakan laporan keuangan. Proses penyusunan laporan keuangan inilah yang belum dipahami oleh pelaku UMKM hal tersebut disebabkan karena kurangnya pemahaman akan pentingnya melakukan pembukuan untuk menghasilkan laporan keuangan. Oleh karena itu tim pengabdian kepada masyarakat STIESIA Surabaya melakukan kegiatan memberikan sosialisasi penyusunan laporan keuangan berbasis SAK EMKM kepada UMKM di Kelurahan Tambaksari Kota Surabaya. Hasil dari kegiataf n ini mendapat tanggapan yang positif bahwa kegiatan ini bermanfaat untuk ketertiban administrasi untuk menghasilkan laporan keuangan dari pelaku UMKM.
Adquisición de fincas virtuales en el metaverso y su problemática en el Derecho inmobiliario
Authors: Guilabert Vidal Mª Remedios
Published: February 2024

El Metaverso, actualmente en desarrollo embrionario, ha comenzado a posibilitar la adquisición de parcelas virtuales sobre la base de la tecnología blockchain con el objeto de realizar innumerables actividades en las mismas, existiendo en este ámbito un mercado extraordinariamente floreciente. La falta de regulación imperante en este sector suscita una variada problemática, la cual abarca desde la naturaleza jurídica de los tokens emitidos en estas operaciones, la traditio de estos activos, el contenido exacto de los derechos ofertados o la adecuada protección jurídica de los eventuales adquirentes, etc. Ante esta disruptiva tecnología, deviene necesario establecer las bases jurídicas que garanticen los derechos de los titulares de estos activos virtuales.
Prognostic significance of tumor suppressor protein p53 in prostate cancer
Authors: Ben Rejeb Sarra , Kouki Nadia , Elfekih Sirine , Cherif Ines , Khouni Hassen
Published: February 2024

Backround: The p53 gene mutation is one of the most common genetic alterations in many cancers. In prostate cancer (PCa), it has been associated with a poor prognosis, tumor progression and aggressiveness. P53 mutation induces an abnormal protein expression in related tissues.
Aim: This study aimed to assess p53 expression using immunohistochemistry in PCa and to discuss its prognostic value.
Methods: We have retrospectively collected all cases of PCa diagnosed in our pathology department between 2012 and 2022. An automatized immunohistochemical analysis was performed using monoclonal p53 antibody. For each case, we assessed the proportion of positive cells and the intensity of staining. P53 expression was considered abnormal when it was totally negative or overexpressed (>=50% of positive cells).
Results: Twenty-four cases have been selected. Abnormal p53 expression was found in 42% of cases (P53 was overexpressed in 6cases and totally negative in 4 cases). Mean age of patients with p53 abnormal expression was 70years old. Patients with p53 abnormal expression had Gleason score >7 in 5 cases, ISUP grade >2 in 3 cases, peri-neural invasion in 8cases, capsule invasion in 9cases. All patients with p53 overexpression developed androgen resistance (p<0.01).
Conclusion: An aberrant expression profile of the p53 protein was observed in 42% of cases, and a statistically significant association was found with androgen resistance. Our results suggest a potential prognostic role of p53 in PCa.
Designing a study on footballers’ injuries in the 2024 African cup of nations competition (Ivory Coast)
Authors: Chaabeni Amr , Kalai Amine , Dhouibi Jaouher , Ben Saad Helmi , Jellad Anis
Published: February 2024

Introduction: To enhance players' performance and implement effective injury prevention protocols and surveillance programs in football, it is essential to conduct epidemiological studies. Since significant disparities in injury rates across various football competitions were reported, it is important to characterize injuries in the context of the African cup of nation (AFCON) competition.
Aim: To determine the incidence and factors associated with injuries among African footballers during the 2024 AFCON competition, which will be held in Ivory Coast from January 13 to February 11, 2024.
Methods: Two expert physician in sports medicine will perform an analytical study (i.e.; a video-based analysis) of the 52 matches that will be played during the 2024 AFCON. The following parameters will be noted: i) Injury incidence, ii) Characteristics of injured players such as age, on-field position, and player league continent, iii) Characteristics ofinjuries such as mechanism, body location, moment of injury in terms of the minute of play and the round of the match, place of the injury in term of stadium zone, replacement consequent to the injury, absence next match, re-injury, recurrence of the injury with the same location during the competition, referee decision, and stoppage time for on-field injury, and iv) Characteristics of matches such as the match’ schedule, ambient temperature, humidity, and wind speed.
Conclusion: This study will allow enriching the existing literature with additional data regarding the injuries and the players’ characteristics in the African context.
Consideraciones sobre la educación inclusiva
Authors: Alejandro Contento Karen Jessenia , Erraéz Alvardo Jhonny Leonardo , Vargas Gaona María del Cisne , Espinoza Freire Enrique Eudaldo
Published: February 2024

The present study responds to a descriptive investigation of bibliographic review type with the objective of unveiling knowledge and considerations on educational inclusion of children and adolescents with special educational needs (SEN). The methodological strategy passed through the methods of documentary and hermeneutic review, through which 137 documentary materials dedicated to the subject were consulted and collated. Among the main findings are the limitations for inclusive educational practice: subjective sociocultural obstacles, curricula and teacher training, as well as the need to establish strategies to alleviate the school failure of these students.
PENGEMBANGAN KOMPETENSI PROFESIONAL GURU PRODUKTIF SMK
Authors: Nurjanah Iis
Published: February 2024

This research is based on the importance of improving the professionalism of teachers, especially private vocational teachers in KORWIL III District Bandung in developing competence through the existing activities in Korwil. This research uses qualitative method with "phenomological naturalistic" approach adopted from Bogdan and and Biklen (I982). This approach puts researchers as the main instrument to directly visit the data source. Document were collected through observation, interview and documentation. Document are expressed in terms of words and analyzed by inductive analysis by expressing the meaning of the observed state. The results of this study reveal: (1) Planning of Professional Teacher Competency Development Activity of SMK begins with a policy undertaken with a) Conducting Activities (KKG) b) obliging (KKG) in each region c) Implementation (KKG) supervised, monitored and evaluated (2) Implementation through KKG work program, namely : general program, core / core, and supporting (3) Evaluation of teacher performance is done by each principal who later reported to the supervisor, by: 1) Observing class activities 2) Review of notes 3) involving various parties as evaluators, (4) Supporting factors a) idealism and work motivation of teachers, educational qualifications, coordination and cooperation among teachers, with Principals and coaches and roles as well as the community. The inhibiting factors are the condition of schools that have not been fully conducive, the lack of balanced rewards, the low welfare received by teachers, and the limited infrastructure. (5) Teachers' participation in productive SMK KKG activity in KORWIL III Bandung regency present well enough with adequate participation and creativity. (6) The advantage of obtaining new information, increasing insight, knowledge and skills, getting a charter.
Pemberdayaan Orangtua Berbasis Kegiatan Parenting untuk Menanamkan Karakter Akhlak Mulia Peserta Didik
Authors: Napisah Cucu
Published: February 2024

Many parents do not understand parenting skills. The aim of this research is to obtain an overview and information about (1) planning for parent empowerment based on parenting activities (2) organizing parent empowerment based on parenting activities (3) Implementation of parent empowerment based on parenting activities (4) evaluation of parent empowerment based on parenting activities (5) obstacles and solutions for empowering parents based on parenting activities. This research uses a qualitative approach and study methods in kindergarten. IPIMAC and TK. Bina Muda Cicalengka District. Bandung. The research results illustrate that (1) in planning, goals have been determined, identified existing problems, identified situations and developed plans (2) In organizing, committees have been formed, infrastructure, time allocation, place of activity implementation, search for reliable resources in parenting, looking for material (3) implementation of parenting activities by holding foundation classes, counseling and parent’s day (4) evaluation carried out after the activity is completed to determine the level of success of the activity (5) obstacles and solutions that occur in parenting activities to achieve the goals that have been set plans must be resolved immediately by finding a solution and implementing the solution. The general conclusion from this research is that parental empowerment based on parenting activities that have been carried out with the guidance of a psychologist can make a positive contribution to the development of students’ noble moral character. The development of students’ character shows positive changes in both behavior and speech
MANAJEMEN USAHA KESEHATAN SEKOLAH DALAM MENINGKATKAN PERILAKU SEHAT SISWA
Authors: Saadudin Idad
Published: February 2024

The non-optimal healthy behavior of junior high school (SMP) students in West Bandung Regency reflects the limited knowledge and weak attitudes of students in School Health Business Activities (UKS) through the implementation of health education, health services and the implementation of healthy education. The school environment is called TRIAS UKS. This research aims to determine and analyze the application of UKS in improving students’ healthy behavior so that middle school students’ learning effectiveness can be realized. UKS management that is not yet optimal and weak student healthy behavior has an impact on student achievement that is less effective. This research uses a qualitative approach with a case study method. The research results show that the planning of UKS activities in three junior high schools has not been based on the results of analysis of the school environment, both internal and external, as mandated in the central UKS guidelines, so that the planning results do not reflect the picture needed by the school. In organizing UKS coaching, schools try as much as possible to involve all school members, but the implementation is not yet supported by description and task mechanisms and does not refer to management indicators, resulting in overlapping activities. UKS mobilization has not been integrated with other programs so that the implementation of health education, health services and a healthy school environment is still partial. UKS control and supervision has been attempted by each school, but it is still not optimal due to weak control and supervision carried out by the District UKS Advisory Team and in accordance with UKS guidelines. The conclusion of the research generally shows that junior high schools in West Bandung Regency are still in Complete Stratification according to the TRIAS UKS indicator which describes the weak health behavior of junior high school students.
Research on integrating university-industry cooperation project cases into curriculum ideological and political construction
Authors: DU Hemin
Published: February 2024

The design major should integrate the advantages of school enterprise cooperation and curriculum ideological and political education, advocate for moral education in education, and enable students to meet the requirements of social development. In application, it is necessary to avoid blurring educational goals, consider the particularity of project-based classrooms, reflect on the complexity of educational environments, innovate curriculum education, improve teacher ideological level, strengthen student curriculum identification, optimize educational evaluation system, and continuously introduce high-quality practical reference paths.
Academician Alexander Konstantinovich Krylov as a teacher and educator
Authors: Mel'nikov Vladimir Leonidovich
Published: February 2024

The subject of this article is the activities of Academician Alexander Konstantinovich Krylov - Academician of the Russian Academy of Arts, Honored Artist of the Russian Federation, painter, laureate of the International Prize named after N.K. Roerich, as a teacher and educator. This is a study of the contribution of Academician Alexander Konstantinovich Krylov to the development of education and science, his teaching methods, pedagogical and educational principles. The author examines in detail the scientific, teaching, social, and creative activities of A.K. Krylova and pays special attention to the educational activities of the academician. The author also presents a complete list of institutions that, according to the State Catalog of the Museum Fund of the Russian Federation and data provided by the artist himself, store his works. The research methodology is presented by the historical method, biographical method, and comparative method. Also, during the preparation of the article, a study was conducted on the basis of archival documents, publications, and pedagogical works of A.K. Krylov and his students. The main conclusions of the study are the creative portrait of the artist presented in this message, which has independent cultural and historical significance and expresses the deeply personal attitude of the author, who hopes that the information and characteristics he collected will be useful to future biographers of the outstanding Russian artist, academician of painting A. K. Krylov. The novelty of the research lies in the generalization of the creative materials of Academician A.K. Krylov, which can be in demand by aspiring artists, art historians, cultural experts, historians and everyone who cherishes the tragic and happy milestones of the steady spiritual growth of Russia - in the past, present and future.
Como nos tornamos os professores que somos: uma problematização da herança estruturalista nas práticas de ensinar e aprender filosofia
Authors: Rodrigues Augusto
Published: February 2024

A proposta deste livro é reconstruir as heranças formativas que, hegemonicamente, modelam a formação do professor de filosofia e sustentam as diretrizes da disciplina no ensino médio brasileiro. Para demonstrar os pressupostos e as práticas que marcam essa herança, o autor nos conduz à tradição de pesquisa e ensino do curso de Filosofia da Universidade de São Paulo, enunciando a figura do professor-explicador: professor formado para explicar os textos clássicos da filosofia à luz da metodologia estruturalista, cujo rigor interpretativo se consolidou a partir da distância entre a explicação e a discussão, debate e avaliação do texto. Problematiza, assim, as condições desse professor para ministrar na educação básica e, mais especificamente, para operar com a filosofia na construção de um pensamento do contemporâneo junto com os estudantes.
Riboflavin Increases Serum Glutamine Levels in Rats with Streptozotocin-induced Diabetes
Authors: Hristov Milen , Sabit Zafer , Kirilov Tsvetomir , Tzoneva Rumiana , Apostolova Sonia , Georgieva Irina , Andreeva-Gateva Pavlina
Published: February 2024

Diabetes mellitus is one of the most common chronic diseases in the world. Metabolomic studies have demonstrated altered blood levels of glutamate and glutamine during type 1 diabetes and type 2 diabetes. Riboflavin is a precursor of flavin adenine dinucleotide and flavin mononucleotide, which are coenzymes necessary for the function of enzymes involved in various biochemical reactions, including those affecting amino acid metabolism. In this study, we investigated the effects of riboflavin on serum glutamate and glutamine levels in rats with streptozotocin-induced type 1 diabetes. Diabetic rats received riboflavin (25 mg, 50 mg, or 100 mg) dissolved in the drinking water daily for 2 weeks. Our results showed that riboflavin supplementation did not affect serum glutamate levels but increased serum glutamine levels in diabetic rats. We speculate that increased serum glutamine levels resulting from riboflavin supplementation may have beneficial effects during diabetes.
Daily natural gas load prediction method based on APSO optimization and Attention-BiLSTM
Authors: Qi Xinjing , Wang Huan , Ji Yubo , Li Yuan , Luo Xuguang , Nie Rongshan , Liang Xiaoyu
Published: February 2024

As the economy continues to develop and technology advances, there is an increasing societal need for an environmentally friendly ecosystem. Consequently, natural gas, known for its minimal greenhouse gas emissions, has been widely adopted as a clean energy alternative. The accurate prediction of short-term natural gas demand poses a significant challenge within this context, as precise forecasts have important implications for gas dispatch and pipeline safety. The incorporation of intelligent algorithms into prediction methodologies has resulted in notable progress in recent times. Nevertheless, certain limitations persist. However, there exist certain limitations, including the tendency to easily fall into local optimization and inadequate search capability. To address the challenge of accurately predicting daily natural gas loads, we propose a novel methodology that integrates the adaptive particle swarm optimization algorithm, attention mechanism, and bidirectional long short-term memory (BiLSTM) neural networks. The initial step involves utilizing the BiLSTM network to conduct bidirectional data learning. Following this, the attention mechanism is employed to calculate the weights of the hidden layer in the BiLSTM, with a specific focus on weight distribution. Lastly, the adaptive particle swarm optimization algorithm is utilized to comprehensively optimize and design the network structure, initial learning rate, and learning rounds of the BiLSTM network model, thereby enhancing the accuracy of the model. The findings revealed that the combined model achieved a mean absolute percentage error (MAPE) of 0.90% and a coefficient of determination (R2) of 0.99. These results surpassed those of the other comparative models, demonstrating superior prediction accuracy, as well as exhibiting favorable generalization and prediction stability.
Multi-grained alignment method based on stable topics in cross-social networks
Authors: Lu Jing , Gai Qikai
Published: February 2024

The user alignment of cross-social networks is divided into user and group alignments, respectively. Obtaining users’ full features is difficult due to social network privacy protection policies in user alignment mode. In contrast, the alignment accuracy is low due to the large number of edge users in the group alignment mode. To resolve this issue, First, stable topics are obtained from user-generated content (UGC) based on embedded topic jitter time, and the weight of user edges is updated by using vector distances. An improved Louvain algorithm, called Stable Topic-Louvain (ST-L), is designed to accomplish multi-level community detection without predetermined tags. It aims to obtain fuzzy topic features of the community and finalize the community alignment across social networks. Furthermore, iterative alignment is executed from coarse-grained communities to fine-grained sub-communities until user-level alignment occurs. The process can be terminated at any layer to achieve multi-granularity alignment, which resolves the low accuracy issue of edge user alignment at a single granularity and improves the accuracy of user alignment. The effectiveness of the proposed method is shown by implementing real datasets.
Telomere length and dynamics in Astyanax mexicanus cave and surface morphs
Authors: Lunghi Enrico , Bilandžija Helena
Published: February 2024

Background

Telomeres are non-coding DNA repeats at the chromosome ends and their shortening is considered one of the major causes of aging. However, they also serve as a biomarker of environmental exposures and their length and attrition is affected by various stressors. In this study, we examined the average telomere length in Astyanax mexicanus, a species that has both surface-dwelling and cave-adapted populations. The cave morph descended from surface ancestors and adapted to a markedly different environment characterized by specific biotic and abiotic stressors, many of which are known to affect telomere length. Our objective was to explore whether telomere length differs between the two morphs and whether it serves as a biological marker of aging or correlates with the diverse environments the morphs are exposed to.

Methods

We compared telomere length and shortening between laboratory-reared Pachón cavefish and Rio Choy surface fish of A. mexicanus across different tissues and ages.

Results

Astyanax mexicanus surface fish exhibited longer average telomere length compared to cavefish. In addition, we did not observe telomere attrition in either cave or surface form as a result of aging in adults up to 9 years old, suggesting that efficient mechanisms prevent telomere-mediated senescence in laboratory stocks of this species, at least within this time frame. Our results suggest that telomere length in Astyanax may be considered a biomarker of environmental exposures. Cavefish may have evolved shorter and energetically less costly telomeres due to the absence of potential stressors known to affect surface species, such as predator pressure and ultra-violet radiation. This study provides the first insights into telomere dynamics in Astyanax morphs and suggests that shorter telomeres may have evolved as an adaptation to caves.
Cyy-287, a novel pyrimidine-2,4-diamine derivative, efficiently mitigates inflammatory responses, fibrosis, and lipid synthesis in obesity-induced cardiac and hepatic dysfunction
Authors: Ni Jinhuan , Zhang Xiaodan , Huang Huijing , Ni Zefeng , Luo Jianchao , Zhong Yunshan , Hui Min , Liu Zhiguo , Qian Jianchang , Zhang Qianwen
Published: February 2024

Background

Inflammation and metabolic disorders are important factors in the occurrence and development of obesity complications. In this study, we investigated the protective effect and underlying mechanism of a novel pyrimidine-2,4-diamine derivative, Cyy-287, on mice fed a high-fat diet (HFD).

Methods

The mice were randomly separated into four groups (n ≥ 7): control (regular diet), HFD, HFD with Cyy-287 (5 mg/kg), and HFD with Cyy-287 (20 mg/kg) following HFD feeding for 10 weeks. After a 10-week administration, ALT and AST enzymes, echocardiography, immunohistochemical (IHC), Western blot (WB), Masson and Sirius Red staining were used to evaluate functional and morphological changes to the heart and liver. Microsomes from the mouse liver were extracted to quantify the total amount of CYP450 enzymes after drug treatment.

Results

Cyy-287 decreased the levels of serum glucose, LDL, TC, ALT, and AST activities in HFD-treated mice. However, Cyy-287 administration increased ejection fraction (EF) and fractional shortening (FS) index of the heart. Cyy-287 inhibited histopathological changes in the heart and liver; decreased inflammatory activity; significantly diminished p38 mitogen-activated protein kinase (MAPK), the nuclear factor-kappa B (NF-κB) axis, and sterol regulatory element-binding protein-1c (SREBP-1c); and upregulated the AMP-activated protein kinase (AMPK) pathway in HFD-treated mice. Cyy-287 restored the content of hepatic CYP450 enzymes.

Conclusion

These findings demonstrated that Cyy-287 protected heart and liver cells from obesity-induced damage by inhibiting inflammation, fibrosis, and lipid synthesis.
Raised water temperature enhances benthopelagic links via intensified bioturbation and benthos-mediated nutrient cycling
Authors: Farrell Eilish M. , Neumann Andreas , Beermann Jan , Wrede Alexa
Published: February 2024

Sediment reworking by benthic infauna, namely bioturbation, is of pivotal importance in expansive soft-sediment environments such as the Wadden Sea. Bioturbating fauna facilitate ecosystem functions such as bentho-pelagic coupling and sediment nutrient remineralization capacities. Yet, these benthic fauna are expected to be profoundly affected by current observed rising sea temperatures. In order to predict future changes in ecosystem functioning in soft-sediment environments like the Wadden Sea, knowledge on the underlying processes such as sediment reworking, is crucial. Here, we tested how temperature affects bioturbation and its associated ecosystem processes, such as benthic nutrient fluxes and sediment oxygen consumption, using luminophore tracers and sediment incubation cores. We used a controlled mesocosm experiment set-up with key Wadden Sea benthos species: the burrowing polychaetes Arenicola marina and Hediste diversicolor, the bivalve Cerastoderma edule, and the tube-building polychaete Lanice conchilega. The highest bioturbation rates were observed from A. marina, reaching up to 375 cm2yr−1; followed by H. diversicolor, with 124 cm2yr−1 being the peak bioturbation rate for the ragworm. Additionally, the sediment reworking activity of A. marina facilitated nearly double the amount of silicate efflux compared to any other species. Arenicola marina and H. diversicolor accordingly facilitated stronger nutrient effluxes under a warmer temperature than L. conchilega and C. edule. The oxygen uptake of A. marina and H. diversicolor within the sediment incubation cores was correspondingly enhanced with a higher temperature. Thus, increases in sea temperatures may initially be beneficial to ecosystem functioning in the Wadden Sea as faunal bioturbation is definitely expedited, leading to a tighter coupling between the sediment and overlying water column. The enhanced bioturbation activity, oxygen consumption, and facilitated nutrient effluxes from these invertebrates themselves, will aid in the ongoing high levels of primary productivity and organic matter production.
Gestão administrativa no poder judiciário sob a visão do juiz-gestor
Authors: Cavalcanti Andréia Luiza Batista Braga , Pederneiras Marcleide Maria Macêdo , De Menezes Paula Dutra Leão , De Oliveira Domingos Gualberto , Cardoso Silvia Karina Alves Barros
Published: February 2024

A presente pesquisa abordou a temática da gestão administrativa no poder judiciário sob a visão do juiz-gestor, apresentando uma análise da gestão realizada nos cartórios das unidades dos juizados especiais do tribunal de justiça de Pernambuco. O estudo objetivou evidenciar a percepção do juiz-gestor acerca da gestão administrativa no poder judiciário e seu impacto na organização cartorária e celeridade da tramitação dos processos nos Juizados Especiais de Pernambuco. Para alcançar esse objetivo, adotou-se uma abordagem qualitativa de natureza exploratória, utilizando uma pesquisa de campo. A coleta de dados ocorreu por meio de um questionário semiestruturado online, aplicado aos Juízes de Direito dos Juizados Especiais do Tribunal de Justiça do Estado de Pernambuco, por meio do qual constatou-se que a implementação de um modelo de gestão inovadora, no qual se promova uma prestação jurisdicional com eficiência, celeridade e razoabilidade diante da superveniência de mais uma função que a figura do Juiz de Direito adquiriu, impôs desafios à administração de suas atividades fins. Concluiu-se que ao melhorar a gestão administrativa, será possível enfrentar os desafios do sistema judicial brasileiro e promover um acesso mais rápido e justo à justiça.
Proposta de uma correção de Hermite em modelos de mistura: uma abordagem comparativa ao modelo de Scheffé no estudo de caso de avaliação sensorial de blends de café
Authors: Mafra Daniela Aparecida , Manoel Iuri dos Santos , Cirillo Marcelo Ângelo , Borém Flávio Meira
Published: February 2024

Em experimentos de misturas é comum adotarmos os modelos de Scheffé ou de Kronecker na modelagem estatística. Em relação às técnicas gráficas, utiliza-se o gráfico trace-plot com o propósito de inferir o efeito direcional nos componentes em relação à variável resposta. Em experimentos que envolvem blends de cafés, é notável que fatores externos, como a altitude, o tipo de processamento e o grau de torrefação, podem influenciar diretamente a relação funcional dos dados com a variável resposta, causando oscilações aleatórias. Ao realizarmos um estudo dos efeitos direcionais por meio do gráfico trace-plot, adotando-se o modelo linear de Scheffé ou o quadrático de Kronecker, as oscilações aleatórias são desconsideradas. O objetivo deste estudo é propor um aprimoramento do procedimento utilizado na construção do gráfico de trace-plot, utilizando polinômios de Hermite, no estudo de caso de avaliação sensorial de blends de cafés. Este procedimento se baseia em uma nova parametrização denominada "modelo de Hermite" e inclui correções na matriz de delineamento associada a esse modelo. Salientamos que ao ajustar-se o modelo de Hermite, a matriz de delineamento perde a propriedade de que a soma das linhas seja igual a um, justificando assim a necessidade de correção. Concluiu-se que o gráfico trace-plot gerado pelo modelo de Hermite proporcionou uma interpretação mais precisa dos efeitos direcionais nos componentes em comparação ao modelo de Scheffé. Além disso, as correções foram capazes de preservar o modelo linear de Scheffé, sem comprometer as informações adicionais presentes no modelo de Hermite.
Orthodontic Treatment and Mini Wing Osteotomy: A Case Report of Changes in Facial Aesthetic
Authors: Faria Fernanda Ramos de , Mota-JÃºnior Sergio Luiz , Moreira Leonardo Metropolo , Ungierowicz Aluan Costa , Gravina Marco Abdo
Published: February 2024

For correction of dentofacial deformities, orthosurgical treatment is recommended and often involves bi-maxillary orthognathic surgery. The chin area is an important key for a harmonious facial profile and plays an important role. The present case (of a 38- year-old female) describes one successful surgical-orthodontic treatment. The treatment consisted of the use of an Edgewise fixed appliance (0.022”×0.028”), mini Wing osteotomy (mWo), correction of the deviated nasal septum, and rhinoplasty. The treatment resulted in a better facial harmony and aesthetic with greater definition and lengthening of the submental region, adipose tissue elimination, and an upturned nose due to the correction of the deviated nasal septum associated with rhinoplasty. The Class I canine and molar relationship, the upper and lower midlines coincident with the facial midline, and the compensatory projection of the lower incisors were maintained. A satisfactory overbite and overjet, and leveled curve of Spee were obtained. In conclusion, the orthodontic treatment associated with mWo, correction of the deviated nasal septum, and rhinoplasty surgery provided satisfactory functional and aesthetic results.