bluuebunny/crossref_metadata_2025 huggingface dataset:
Hotspots and Frontiers of Host Immune Response in Idiopathic Pulmonary Fibrosis: A Bibliometric and Scientific Visual Research from 2000 to 2022
Authors: Li Shirong , Zhao Pengyue , Wang Chao , Xia Yun , Wang Haoyan , Qi Wenjie
Published: April 2023

Background. Idiopathic pulmonary fibrosis (IPF) is a disease with significant morbidity, progressive deterioration of lung function till death, and lack of effective treatment options. This study aims to explore the global research trends in IPF and immune response to predict the research hotspot in the future. Materials and methods. All related publications on IPF and immune response since the establishment of diagnostic criteria for IPF were retrieved using the Web of Science (WOS) database. VOSviewer, GraphPad Prism 6, CiteSpace version 5.6. R5 64-bit, and a bibliometrics online platform were used to extract and analyze the trends in relevant fields. Results. From March 1, 2000, to September 30, 2022, a total of 658 articles with 25,126 citations met the inclusion criteria. The United States ranked first in number of publications (n = 217), number of citations (n = 14,745), and H-index (62). China ranked second in publications (n = 124) and seventh and fifth for citation frequency and H-index, respectively. The American Journal of Respiratory and Critical Care Medicine (impact factor = 30.528) published the most articles in the field. The author Kaminski N. from the United States was the most influential author with 26 publications and an H-index of 24. Among the 52 keywords that co-occurred at least 20 times, the main keywords were concentrated in “Inflammation related” and “Biomarker related” clusters. “biomarker” (AAY 2018.64, 25 times) was a newly emerged keyword. Conclusions. The United States has an unequivocal advantage in IPF and immunization, but China shows a faster developing trend. The American Journal of Respiratory and Critical Care Medicine should be prioritized for leading articles. This study indicates that exploration of ideal immune-related biomarkers to provide evidence for the clinical work of IPF might be a hotspot in the near future.
Facile Synthesis and Application of Ag-NPs for Controlling Antibiotic-ResistantPseudomonas spp. and Bacillus spp. in a Poultry Farm Environment
Authors: Rahman Aminur , Rasid Harunur , Ali Md. Isahak , Yeachin Nymul , Alam Md. Shahin , Hossain Khandker Saadat , Kafi Md. Abdul
Published: April 2023

This study synthesized silver nanoparticles (Ag-NPs) using silver nitrate (AgNO3) as the ion source and sodium tripolyphosphate (STPP) as reducing as well as capping agents. The synthesized Ag-NPs were confirmed initially using Ag-NPs specific λmax at 410 nm with UV-Vis spectrophotometry and homogenously distributed, 100–300 nm size, and round-shaped particles were realized through atomic force microscopy (AFM) and transmission electron microscopy (TEM) image analysis. The various reaction condition-based studies revealed 0.01 M AgNO3 yields maximum particle after 4 h reduction with 1% STPP. Bacillus spp. (n = 23/90) and Pseudomonas spp. (n = 26/90) were isolated from three different poultry farms for evaluating the antibacterial activity of Ag-NPs. Among the PCR confirmed isolates, 52% (12/23) Bacillus spp. were resistant to ten antibiotics and 65% (17/26) Pseudomonas spp. were resistant to eleven antibiotics. The representative resistant isolates were subjected to antibacterial evaluation of synthesized Ag-NPs following the well diffusion method, revealing the maximum sensitive zone of inhibition 19 ± 0.2 mm against Bacillus spp. and 17 ± 0.38 mm against Pseudomonas spp. The minimum inhibitory concentration (MIC) and minimum bacterial concentration (MBC) of Ag-NPs were 2.1 μg/ml and 8.4 μg/ml, respectively, for broad-spectrum application. Finally, the biocompatibility was determined by observing the viability of Ag-NP-treated BHK-21 cell through trypan blue-based exclusion assay revealing nonsignificant decreased of cell viability ≤2MIC doses. Thus, the synthesized Ag-NPs were proven as biocompatible and sensitive to both Gram-positive and Gram-negative bacteria of the poultry farm environmental samples.
Macrophages Phenotype Regulated by IL-6 Are Associated with the Prognosis of Platinum-Resistant Serous Ovarian Cancer: Integrated Analysis of Clinical Trial and Omics
Authors: Wu Xiaoqing , Lu Wenping , Xu Chaojie , Jiang Cuihong , Zhuo Zhili , Wang Ruipeng , Zhang Dongni , Cui Yongjia , Chang Lei , Zuo Xi , Wang Ya’nan , Mei Heting , Zhang Weixuan , Zhang Mengfan , Li Chen
Published: April 2023

Background. The treatment of platinum-resistant recurrent ovarian cancer (PROC) is a clinical challenge and a hot topic. Tumor microenvironment (TME) as a key factor promoting ovarian cancer progression. Macrophage is a component of TME, and it has been reported that macrophage phenotype is related to the development of PROC. However, the mechanism underlying macrophage polarization and whether macrophage phenotype can be used as a prognostic indicator of PROC remains unclear. Methods. We used ESTIMATE to calculate the number of immune and stromal components in high-grade serous ovarian cancer (HGSOC) cases from The Cancer Genome Atlas database. The differential expression genes (DEGs) were analyzed via protein–protein interaction network, Kyoto Encyclopedia of Genes and Genomes (KEGG) and gene ontology (GO) analysis to reveal major pathways of DEGs. CD80 was selected for survival analysis. IL-6 was selected for gene set enrichment analysis (GSEA). A subsequent cohort study was performed to confirm the correlation of IL-6 expression with macrophage phenotype in peripheral blood and to explore the clinical utility of macrophage phenotype for the prognosis of PROC patients. Results. A total of 993 intersecting genes were identified as candidates for further survival analysis. Further analysis revealed that CD80 expression was positively correlated with the survival of HGSOC patients. The results of GO and KEGG analysis suggested that macrophage polarization could be regulated via chemokine pathway and cytokine–cytokine receptor interaction. GSEA showed that the genes were mainly enriched in IL-6-STAT-3. Correlation analysis for the proportion of tumor infiltration macrophages revealed that M2 was correlated with IL-6. The results of a cohort study demonstrated that the regulation of macrophage phenotype by IL-6 is bidirectional. The high M1% was a protective factor for progression-free survival. Conclusion. Thus, the macrophage phenotype is a prognostic indicator in PROC patients, possibly via a hyperactive IL-6-related pathway, providing an additional clue for the therapeutic intervention of PROC.
[Retracted] The Research on Intelligent Measurement Terminal of Water‐Saving Irrigation Based on RN2026 Microcontroller
Authors: Guo Runzhou , Liu Shujie , Liu Xiaoxiao , Liu Beilei , Gu Zhanlei
Published: April 2023

Water‐saving irrigation technology has been studied for many years, but due to insufficient investment in research and development of irrigation equipment, it cannot be effectively promoted and applied. In order to improve the water use efficiency of farmland irrigation, the automatic monitoring of groundwater level change, soil moisture change, and crop seasonal growth status is realized in the ditch or pump well irrigation area. An intelligent measuring terminal for water‐saving irrigation based on RN2026 microcontroller is developed. The terminal uses the coefficient of “water conversion by electricity” to automatically convert the water consumption of farmers and uses the price mechanism of water rights to affect farmers’ water conservation. In combination with changes in groundwater level, crop evapotranspiration, and dynamic changes in soil moisture, precision irrigation strategies are automatically generated to guide farmers to use water rationally. Through the function and performance experiments, the results show that the error of the coefficient of “water conversion by electricity” is less than 1%, the error of electric energy measurement is less than 0.5%, the estimated value of average water use right per unit arable area is consistent with the actual value, and the predicted value of daily average soil moisture change is consistent with the measured value. The equipment has strong adaptability to the environment, high measurement accuracy, strong data processing ability, low cost, and other characteristics. It meets the requirements of water‐saving irrigation technology in practical applications and has good promotion and application value.
Laboratory-Scale Optimization of Hemp Seed Roasting Temperature and Time for Producing a High-Quality Pressed Oil
Authors: Mansouri Farid , Allay Aymane , Moumen Abdessamad Ben , Benkirane Chaymae , Taaifi Yassine , Belhaj Kamal , Addi Mohamed , Hano Christophe , Fauconnier Marie-Laure , Caid Hana Serghini , Elamrani Ahmed
Published: April 2023

Roasting is widely applied in oil processing to improve the extraction yield and desired sensory characteristics. The current study is aimed at optimizing roasting conditions (time and temperature) of hemp (Cannabis sativa L.) seeds prior to seed pressing to improve the oil yield and antioxidant capacity, using response surface methodology based on central composite design (CCD). Hemp seeds were roasted at five temperatures (132, 140, 160, 180, and 188°C) and for five duration times (9, 15, 30, 45, and 51 min). Mathematical models have shown that roasting conditions significantly affected response variables (

p
<
0.05

), including oil yield, total phenolic content (TPC), radical scavenging activity, and oxidative stability index (OSI). The CCD led to the following optimum roasting conditions: 163°C for 15 min, which improved the extraction yield by 45% and oxidative stability by 80%. Thus, the oil produced under these conditions showed a yield of 23.09%, TPC of 121.21 mg GAE kg-1, and OSI of 21.37 hours. In addition, roasting hemp seeds under optimal conditions did not negatively influence the oil quality. Only chlorophylls, tocopherols, and palmitic acid slightly decreased (

p
<
0.05

) after roasting (from 39.10 to 36.54 mg kg-1, 483.06 to 469.77 mg kg-1, and 7.65 to 7.29%, respectively). Furthermore, the concentrations of most volatile compounds identified in unroasted hemp seeds decreased after roasting under optimal conditions, with the formation of new compounds sought for their positive attributes, such as pyrazines and aldehydes derived from the Strecker degradation, responsible for the roasted, nutty, and almond odors. The main volatile compounds in raw and roasted hemp seeds were β-myrcene (3170.30 and 1177.69 ng g-1, respectively) and D-limonene (1347.25 and 470.35 ng g-1, respectively). The results obtained in this study could provide valuable information for the food industry to produce hemp seed oil with high nutritional quality that meets consumer demands.
Existence of Mild Solutions for Nonlocal Evolution Equations with the Hilfer Derivatives
Authors: Elbukhari Abu Bakr , Fan Zhenbin , Li Gang
Published: April 2023

The existence of mild solutions for Hilfer fractional evolution equations with nonlocal conditions in a Banach space is investigated in this manuscript. No assumptions about the compactness of a function or the Lipschitz continuity of a nonlinear function are imposed on the nonlocal item and the nonlinear function, respectively. However, we assumed that the nonlocal item is continuous, the nonlinear term is continuous and satisfies some specified assumptions, and the associated semigroup is compact. Our theorems are proved by means of approximate techniques, semigroup methods, and fixed point theorem. These methods are useful for fixing the noncompactness of operators caused by some specified given assumptions on this paper. The results obtained here improve some known results. Finlay, two examples are presented for illustration of our main results.
Theoretical Study of a Design Method for Underexcavation in Building Rectification
Authors: Xiao Jun-Hua , Sun Jian-Ping , Zhang Xin , Jiang Zong-Bao , Guo Dao-Tong
Published: April 2023

For buildings with shallow foundations embedded in natural soil sediments, the underexcavation method is often used to correct building inclination. Relying on engineering experience and close field monitoring, rectification has been conducted successfully. However, theoretical studies are relatively scarce, resulting in an inadequately informed rectification design and procedure. Assuming the soil is an ideal elastic-plastic body, a simplified analysis was adopted to study the issue theoretically. First, the redistribution of the base contact pressure after building inclination was deduced. Second, according to the force balance between the total contact pressure of the base and the total stress on the horizontal plane at the excavation hole, the limit hole spacing at the critical state of building back tilt was obtained, which was also the preferable hole spacing for soil strip collapse. Third, because the amount of anticipated forced settlement at a certain section of soil excavation is equal to the volume of soil hole collapse, an accurate formula for the hole diameter was obtained. Combined with engineering experience, suggestions for the design procedure were proposed. Finally, two case histories were introduced to verify the correctness and practicability of the theoretical formula for hole spacing and diameter. These two key parameters provide a strong theoretical basis for building rectification in future engineering practice.
Reinforcement of Nanocellulose as Green Agent in the Electronic Applications Associated with the Composites of Polymer Matrix
Authors: Alagarsamy Manjunathan , Barkunan S. R. , Jayapal N. , Murugan A. , Muralikrishnan P. , Ramulu Perumalla Janaki
Published: April 2023

Due to their profusion, high durability, and rigidity, lesser weight and biodegradable nature nanocellulose (NC) is observed as the challenging tasks for the aspirants in making of the green composites. The continuous network of the cellulose nanoparticle connected through hydrogen bonding is happened mainly due to the reinforcing effect allocated to the mechanical reoccurrence phenomenon of the NC. When comparing with the nanocrystalline cellulose, the NC has significant convincing progress in the durability and rigidity, and the aspect ratio of the NC is higher than that of the NC crystal. The reinforcement effect of NC is the characteristic of the NC polymer interaction as well as the reinforcement effect eventualizing through stress transfer at the NC–polymer interface. Thus, the concentration of the reinforcement particle rises to the saturation level due to the frailty of the NC reinforcement constituent and due to surface compliance between the matrix and the filler. Due to its structural firmness and mechanical behaviors, the NC compounds are used in many industrial applications like tissue engineering, food packaging, and electronic applications. The stretchable electronic systems and instruments are awaiting the maximal attention due to its essential applications in certain domains, such as robotics artificial intelligence, brain control and machine interface, clinical devices, and health care electronic monitoring devices. In addition to that, when realizing the operational performance of electronic devices, the electronic instruments and systems must be physically expandable and flexible. The proposed study deems the technique of reinforcing the NC compounds as green agent in electronic applications, which has been associated with the composites of polymer matrix. The elongation could be achieved through the formulation of composition via elastomers. In addition, it is being focused on the illustration of functional soft development of materials that is inclusive of the conductive intrinsic polymers for the elongated electrodes and electrothermal conversion and vice versa, occupying the maximal area along with tactile sensing elements.
ZDHHC2-Mediated AGK Palmitoylation Activates AKT–mTOR Signaling to Reduce Sunitinib Sensitivity in Renal Cell Carcinoma
Authors: Sun Yan , Zhu Liang , Liu Pian , Zhang Huan , Guo Feng , Jin Xin
Published: April 2023

Tyrosine kinase inhibitors (TKI) that can suppress the VEGF signaling pathway and angiogenesis have been developed to impede the progression of malignant tumors and have been approved as first-line targeted agents for clear cell renal cell carcinoma (ccRCC). Dysregulation of lipid metabolism is a major driver of TKI resistance in renal cancer. In this study, we showed that the palmitoyl acyltransferase ZDHHC2 is abnormally upregulated in tissues and cell lines resistant to TKIs, such as sunitinib. Upregulation of ZDHHC2 contributed to sunitinib resistance in cells and mice, and ZDHHC2 regulated angiogenesis and cell proliferation in ccRCC. Mechanistically, ZDHHC2 mediated AGK S-palmitoylation to promote translocation of AGK into the plasma membrane and activation of the PI3K–AKT–mTOR signaling pathway in ccRCC, which modulated sunitinib sensitivity. In conclusion, these results identify a ZDHHC2–AGK signaling axis and suggest that ZDHHC2 is a targetable candidate for improving the antitumor efficacy of sunitinib in ccRCC.

Significance:

ZDHHC2 confers sunitinib resistance to clear cell renal cell carcinoma by catalyzing AGK palmitoylation to activate the AKT–mTOR pathway.
Selective Inhibition of ATM-dependent Double-strand Break Repair and Checkpoint Control Synergistically Enhances the Efficacy of ATR Inhibitors
Authors: Turchick Audrey , Zimmermann Astrid , Chiu Li-Ya , Dahmen Heike , Elenbaas Brian , Zenke Frank T. , Blaukat Andree , Vassilev Lyubomir T.
Published: April 2023

Ataxia telangiectasia and Rad3-related protein (ATR) kinase regulate a key cell regulatory node for maintaining genomic integrity by preventing replication fork collapse. ATR inhibition has been shown to increase replication stress resulting in DNA double-strand breaks (DSBs) and cancer cell death, and several inhibitors are under clinical investigation for cancer therapy. However, activation of cell-cycle checkpoints controlled by ataxia telangiectasia–mutated (ATM) kinase could minimize the lethal consequences of ATR inhibition and protect cancer cells. Here, we investigate ATR-ATM functional relationship and potential therapeutic implications. In cancer cells with functional ATM and p53 signaling, selective suppression of ATR catalytic activity by M6620 induced G1-phase arrest to prevent S-phase entry with unrepaired DSBs. The selective ATM inhibitors, M3541 and M4076, suppressed both ATM-dependent cell-cycle checkpoints, and DSB repair lowered the p53 protective barrier and extended the life of ATR inhibitor–induced DSBs. Combination treatment amplified the fraction of cells with structural chromosomal defects and enhanced cancer cell death. ATM inhibitor synergistically potentiated the ATR inhibitor efficacy in cancer cells in vitro and increased ATR inhibitor efficacy in vivo at doses that did not show overt toxicities. Furthermore, a combination study in 26 patient-derived xenograft models of triple-negative breast cancer with the newer generation ATR inhibitor M4344 and ATM inhibitor M4076 demonstrated substantial improvement in efficacy and survival compared with single-agent M4344, suggesting a novel and potentially broad combination approach to cancer therapy.
Risk Factors for Early-onset Sporadic Colorectal Cancer in Male Veterans
Authors: Imperiale Thomas F. , Myers Laura J. , Barker Barry C. , Larson Jason , Stump Timothy E. , Daggy Joanne K.
Published: April 2023

Identifying risk factors for early-onset colorectal cancer (EOCRC) could help reverse its rising incidence through risk factor reduction and/or early screening. We sought to identify EOCRC risk factors that could be used for decisions about early screening. Using electronic databases and medical record review, we compared male veterans ages 35 to 49 years diagnosed with sporadic EOCRC (2008–2015) matched 1:4 to clinic and colonoscopy controls without colorectal cancer, excluding those with established inflammatory bowel disease, high-risk polyposis, and nonpolyposis syndromes, prior bowel resection, and high-risk family history. We ascertained sociodemographic and lifestyle factors, family and personal medical history, physical measures, vital signs, medications, and laboratory values 6 to 18 months prior to case diagnosis. In the derivation cohort (75% of the total sample), univariate and multivariate logistic regression models were used to derive a full model and a more parsimonious model. Both models were tested using a validation cohort. Among 600 cases of sporadic EOCRC [mean (SD) age 45.2 (3.5) years; 66% White], 1,200 primary care clinic controls [43.4 (4.2) years; 68% White], and 1,200 colonoscopy controls [44.7 (3.8) years; 63% White], independent risk factors included age, cohabitation and employment status, body mass index (BMI), comorbidity, colorectal cancer, or other visceral cancer in a first- or second-degree relative (FDR or SDR), alcohol use, exercise, hyperlipidemia, use of statins, NSAIDs, and multivitamins. Validation c-statistics were 0.75–0.76 for the full model and 0.74–0.75 for the parsimonious model, respectively. These independent risk factors for EOCRC may identify veterans for whom colorectal cancer screening prior to age 45 or 50 years should be considered.

Prevention Relevance:

Screening 45- to 49-year-olds for colorectal cancer is relatively new with uncertain uptake thus far. Furthermore, half of EOCRC occurs in persons < 45 years old. Using risk factors may help 45- to 49-year-olds accept screening and may identify younger persons for whom earlier screening should be considered.

See related Spotlight, p. 479
A Review of the Scoring and Assessment of Keratosis Pilaris
Authors: Wang Madeline Anne , Wilson Anna , Murrell Dedee Frances
Published: April 2023

Disease severity assessment tools play a large part in evaluating skin conditions in dermatology. Currently, there is no existing validated assessment tool for keratosis pilaris (KP), a benign yet highly prevalent follicular disorder. A range of proposed scoring tools have been used in different clinical trials for the assessment of potential treatments for KP. A literature review of the current scoring systems used for KP shows that there is a lack of consistency with most studies using varying versions of unvalidated investigator global assessment (IGA) scores and quartile grading systems. A review of these studies shows that current methods of evaluating KP in clinical trials are subjective, unreliable, and inconsistent. A standardised and validated scoring system would be significant as it could be used in clinical trials to advance the current knowledge of KP.
Erosive Potential of Various Beverages in the United Arab Emirates: pH Assessment
Authors: Nassar Mohannad , Islam Md Sofiqul , Hasan Noor , Al-Khazraji Ahmed , Maki Husain
Published: April 2023

Objectives: The United Arab Emirates (UAE) is one of the top 5 countries in the world in terms of juice consumption per capita. The rising consumption of beverages is a major contributor to a plethora of diseases, including heightened risks of developing obesity, diabetes, and osteoporosis. Beverages with low pH also tend to magnify the risk of long-term dental erosion. This paper evaluated the pH of various beverages in the UAE to help determine their erosive potential. Materials and Methods: 306 beverages were collected from different stores in the UAE. Drinks were categorized into 8 categories: carbonated drinks, energy drinks, sparkling water, iced teas, juices, malt beverages, coconut water, and sports drinks. Three readings were taken for each drink using a pH meter at room temperature. Results: 88% of all beverages had a pH of less than 4.0, and the remaining 12% had a pH of 4.0 or more. 37% of the beverages tested were extremely erosive (pH < 3.0), 51% were erosive (pH 3.0–3.99), and 12% were mildly erosive (pH ≥ 4.0). Bickford’s Classic Cola and Tesco Lemon Juice were the most acidic beverages (pH < 2.4). The most identified acids in the tested beverages were citric, phosphoric, ascorbic, and malic acids. Conclusions: The majority of beverages in the UAE are erosive to dentition as the pH is below 4. Future studies to raise public awareness on the effect of acidic drinks on tooth structure are needed.
Knowledge and Attitudes towards Dementia among the General Public in Singapore: A Comparative Analysis
Authors: Hansra Gurpreet Kaur , Lim Hazel , Cheong Chin Yee , Yap Philip
Published: April 2023

Introduction: This paper provides a summary of findings on the public’s knowledge and attitudes towards dementia. We aim to investigate if the attitudes of Singaporeans towards dementia have changed over the years by adopting a questionnaire used in a similar study in 2012. Methods: A cross-sectional, descriptive study was conducted through the dissemination of an existing, online questionnaire to participants above 16 years of age. Out of 1,500 subjects, results from 1,373 participants were analysed. Descriptive statistics were used to analyse and compare results from the 2012 study while a latent class analysis was performed to understand the categories of study participants based on varying levels of attitudes, knowledge and stigma. Results: The mean age of study participants was 43.8 (SD = 15.7). Majority of the participants were females (76.5%), between 51 and 60 years of age (29.6%) and belonged to the Chinese ethnic group (77.8%). Results demonstrated that there were significant differences in attitudes towards dementia between 2012 and 2021. There was a 70.2% improvement in stigma-associated attitudes and an increase in correct responses to 4 out of 5 questions in the knowledge section. Conclusion: Findings of this study suggest that the general public has a better knowledge and more positive attitude towards dementia. This could have been attributed to higher literacy levels of the current study population and effectiveness of established outreach initiatives in Singapore. However, further research with a more balanced representation of ethnic and cultural groups would offer more comprehensive insights into dementia health literacy.
A morte de Edward Gordon Craig: visualidades místicas de um pensamento Über
Authors: Silva Filho Almir Ribeiro da
Published: April 2023

O apelo à plasticidade é um dos fundamentos da proposta visual da nova arte da encenação inaugurada por Edward Gordon Craig no início do século XX. Esse apelo possui um eixo central inusitado, baseado em uma visão de mundo particular de seu autor: o misticismo. Ao desenvolver sua obra multifacetada, Craig criou um universo místico em que refletia sobre os limites da linguagem teatral, mas também sobre as frestas entre a vida, a não vida e a morte. Duas de suas realizações mais importantes – a montagem de Hamlet e a criação do Übermarionette – oferecem argumentos definitivos em relação ao papel da Morte na obra de Gordon Craig.
BCL6B Contributes to Ocular Vascular Diseases via Notch Signal Silencing
Authors: Tanaka Miruto , Nakamura Shinsuke , Sakaue Tomohisa , Yamamoto Takumi , Maekawa Masashi , Nishinaka Anri , Yasuda Hiroto , Yunoki Kaori , Sato Yuji , Sawa Masaaki , Yoshino Kohichiro , Shimazawa Masamitsu , Hatano Masahiko , Tokuhisa Takeshi , Higashiyama Shigeki , Hara Hideaki
Published: April 2023

Background:

Endothelial cell activation is tightly controlled by the balance between VEGF (vascular endothelial cell growth factor) and Notch signaling pathway. VEGF destabilizes blood vessels and promotes neovascularization, which are common features of sight-threatening ocular vascular disorders. Here, we show that BCL6B (B-cell CLL/lymphoma 6 member B protein), also known as BAZF, ZBTB28, and ZNF62, plays a pivotal role in the development of retinal edema and neovascularization.

Methods:

The pathophysiological physiological role of BCL6B was investigated in cellular and animal models mimicking 2 pathological conditions: retinal vein occlusion and choroidal neovascularization. An in vitro experimental system was used in which human retinal microvascular endothelial cells were supplemented with VEGF. Choroidal neovascularization cynomolgus monkey model was generated to investigate the involvement of BCL6B in the pathogenesis. Mice lacking BCL6B or treated with BCL6B-targeting small-interfering ribose nucleic acid were examined for histological and molecular phenotypes.

Results:

In retinal endothelial cells, the BCL6B expression level was increased by VEGF. BCL6B-deficient endothelial cells showed Notch signal activation and attenuated cord formation via blockage of the VEGF-VEGFR2 signaling pathway. Optical coherence tomography images showed that choroidal neovascularization lesions were decreased by BCL6B-targeting small-interfering ribose nucleic acid. Although BCL6B mRNA expression was significantly increased in the retina, BCL6B-targeting small-interfering ribose nucleic acid suppressed ocular edema in the neuroretina. The increase in proangiogenic cytokines and breakdown of the inner blood-retinal barrier were abrogated in BCL6B knockout (KO) mice via Notch transcriptional activation by CBF1 (C promotor-binding factor 1) and its activator, the NICD (notch intracellular domain). Immunostaining showed that Müller cell activation, a source of VEGF, was diminished in BCL6B-KO retinas.

Conclusions:

These data indicate that BCL6B may be a novel therapeutic target for ocular vascular diseases characterized by ocular neovascularization and edema.
Singular Reference
Authors: Hildebrandt Frauke , Glauer Ramiro
Published: April 2023

The ability to refer to objects – singular reference – is arguably the decisive innovation on the way to human propositional cognition. This article argues that object individuation requires singular reference because basic singular terms, namely spatial indexicals, provide a symbolic frame of reference for object individuation. The authors suggest that singular reference is intrinsically connected to essential characteristics of propositionality: among other things, it guarantees the situation-independence of meaning, allows for the distinction between truth and falsehood, and enables us to think about possibilities. The authors sketch how singular reference gives rise to the development of predication, the powerful logical tool of quantification, and forms the basis for differentiating between belief and desire.
Religious Family Agreements
Authors: Bix Brian H.
Published: April 2023

The article offers an overview of recent United States court cases on the topic of religious family agreements, focusing in particular on cases seeking to enforce mahr provisions, provisions of ketubahs, and religious upbringing agreements. Overall, the recent cases display the tensions created by an intersection of separate concerns: interpretive, doctrinal, and constitutional. The cases ultimately display a cautious approach, including a general reluctance to enforce provisions where doing so might interfere with religious freedom or override the financial rights of vulnerable parties.
A new species of the genus Eterusia Hope from western China (Lepidoptera, Zygaenidae, Chalcosiinae)
Authors: HUANG SI-YAO , ZHANG YU-LONG , HORIE KIYOSHI , ESPELAND MARIANNE
Published: April 2023

A new species Eterusia sinoraja Huang & Horie sp. n. is described from western Sichuan Province, western China. The comparison is made with the reminiscent E. raja Moore, 1859 from northeastern India. The adult and genitalia of both sexes of the aforementioned taxa are illustrated.
Bias and Uncertainty of the Relationship between AO and Winter Synoptic Temperature Variability over the Northern Hemisphere under Present and Future Climate
Authors: Jian Yuntao , Leung Marco Y. T. , Zhang Ruhua , Zhou Wen , Jian Maoqiu , Yang Song , Feng Yerong , Zhang Banglin
Published: April 2023

In this study, the relationship between AO and winter synoptic temperature variability (STV) over the Northern Hemisphere is examined in 34 CMIP5/CMIP6 model outputs. With significant model bias around the North Pacific and North Atlantic, most models fail to capture the correct AO–STV pattern in historical simulations compared to observations. To investigate the bias of AO–STV relationship simulations, AO-related processes for the connection between AO and winter STV are examined in high pattern score (HPS) models and low pattern score (LPS) models, respectively. Furthermore, the bias of AO impact can be traced back to AO pattern simulations. On the one hand, compared to observations, HPS models can overall capture the intensity in the North Pacific and North Atlantic center of AO. On the other hand, LPS models tend to overestimate the North Pacific center and underestimate the North Atlantic center. In addition, similar to historical simulations, a robust AO–STV relationship can still be found over the Northern Hemisphere in future projections based on HPS models. Meanwhile, the uncertainty of the projected AO–STV relationship in the multimodel ensemble is confined mainly to the North Pacific, consistent with the large diversity of intensity over the North Pacific center of AO, which is related to the uncertainty of the relationship between AO and regional mode variability.
Tail Dependence as a Measure of Teleconnected Warm and Cold Extremes of North American Wintertime Temperatures
Authors: Krock Mitchell L. , Monahan Adam H. , Stein Michael L.
Published: April 2023

Current models for spatial extremes are concerned with the joint upper (or lower) tail of the distribution at two or more locations. Such models cannot account for teleconnection patterns of 2-m surface air temperature (T2m) in North America, where very low temperatures in the contiguous United States may coincide with very high temperatures in Alaska in the wintertime. This dependence between warm and cold extremes motivates the need for a model with opposite-tail dependence in spatial extremes. This work develops a statistical modeling framework that has flexible behavior in all four pairings of high and low extremes at pairs of locations. In particular, we use a mixture of rotations of common Archimedean copulas to capture various combinations of four-corner tail dependence. We study teleconnected T2m extremes using ERA5 of daily average 2-m temperature during the boreal winter. The estimated mixture model quantifies the strength of opposite-tail dependence between warm temperatures in Alaska and cold temperatures in the midlatitudes of North America, as well as the reverse pattern. These dependence patterns are shown to correspond to blocked and zonal patterns of midtropospheric flow. This analysis extends the classical notion of correlation-based teleconnections to considering dependence in higher quantiles.
Challenges in the Description of Sea Ice for a Kilometer-Scale Weather Forecasting System
Authors: Müller Malte , Batrak Yurii , Dinessen Frode , Grote Rafael , Wang Keguang
Published: April 2023

Simulation of atmosphere–ocean–ice interactions in coupled Earth modeling systems with kilometer-scale resolution is a new challenge in operational numerical weather prediction. This study presents an assessment of sensitivity experiments performed with different sea ice products in a convective-scale weather forecasting system for the European Arctic. On kilometer-scale resolution sea ice products are challenged by the large footprint of passive microwave satellite observations and issues with spurious sea ice detection of the higher-resolution retrievals based on synthetic aperture radar instruments. We perform sensitivity experiments with sea ice concentration fields of 1) the global ECMWF-IFS forecast system, 2) a newly developed multisensor product processed through a coupled sea ice–ocean forecasting system, and 3) the AMSR2 product based on passive microwave observations. There are significant differences between the products on O(100) km scales in the northern Barents Sea and along the Marginal Ice Zone north of the Svalbard archipelago and toward the Fram Strait. These differences have a direct impact on the modeled surface skin temperature over ocean and sea ice, the turbulent heat flux, and 2-m air temperature (T2M). An assessment of Arctic weather stations shows a significant improvement of forecasted T2M in the north and east of Svalbard when using the new multisensor product; however, south of Svalbard this product has a negative impact. The different sea ice products are resulting in changes of the surface turbulent heat flux of up to 400 W m−2, which in turn results in T2M variations of up to 5°C. Over a 2-day forecast lead time this can lead to uncertainties in weather forecasts of about 1°C even hundreds of kilometers away from the sea ice.

Significance Statement

Weather forecasting in polar regions requires an accurate description of sea ice properties due to the very important atmosphere–ocean–ice interactions. With the increasing resolution of weather forecasting systems, there is also a need to advance the resolution of the sea ice characteristics in the models. This is, however, not straightforward due to various issues in the sea ice satellite products. This study explores new products and approaches to integrate high-resolution sea ice in a weather prediction system. We find that the model is sensitive to the choice of the sea ice product and that it is still challenging to provide an accurate sea ice field on a kilometer-scale resolution.
A novel magnetic circuit and structure for magnetic levitation ruler
Authors: Sun Jiyuan , Li Pin , Zheng Yan , Tian Chunlin , Zhou Zhenxiong
Published: April 2023

The single axis linear displacement measurement system of CMM is composed of grating ruler, servo motor and linear motion mechanism. Although the measuring accuracy of grating ruler is high, the accuracy of servo motor and linear motion mechanism is low. Therefore, the complex structure limits the measurement accuracy of the linear displacement measurement system. This paper introduces a novel linear displacement measurement system named magnetic levitation ruler. According to the working principle of grating ruler and the characteristics of magnetic levitation technology, the magnetic circuit design and structural design of magnetic levitation ruler are completed in this paper. The mover core of the magnetic levitation ruler is in the stable working magnetic field provided by the stator yoke. The horizontal control coil wound on the mover core can obtain more stable ampere force to improve the control accuracy of the mover core displacement. Therefore, the mover core can be moved in step mode, and the length of each step is fixed. Each step is the minimum scale of the magnetic levitation ruler. Therefore, the mover core can implement displacement measurement while moving in a linear motion. This paper analyzes the working principle of levitation, horizontal motion, and displacement measurement of magnetic levitation ruler, and determines the structural materials and parameters of magnetic levitation ruler with the help of finite element analysis software. The simulation results show that the levitation force of the magnetic levitation ruler is proportional to the current passing through the levitation coils, and the thrust of the horizontal control coil is less disturbed by the magnetic field. Compared with the linear displacement measurement system with rotational servo motor or permanent magnet synchronous linear motor as the core, the magnetic levitation ruler has stable magnetic field, strong controllability, high integration, and is easier to achieve high-precision control.
Joseph E. Maddy’s Instrumental Music Lessons via Radio
Authors: Hash Phillip M.
Published: April 2023

The purpose of this study was to examine instrumental music lessons taught for schoolchildren over the radio by Joseph Maddy in the 1930s and early 1950s. Research questions addressed (a) conditions, circumstances, and details surrounding the lessons and (b) pedagogical principles, strategies, methods, and didactic materials utilized in these broadcasts. Maddy, a pioneer in music education and a professor at the University of Michigan, taught band instruments over WJR in Detroit beginning in February 1931. He added lessons for strings in January 1933 and continued both series for the next four years. After a successful trial over WMAQ in Chicago during the 1935–1936 school year, the National Broadcasting Company (NBC) scheduled Maddy’s band lessons nationwide starting with the 1936–1937 season. Maddy expanded the program beginning fall 1937 to include winds, percussion, orchestral strings, piano, accordion, and fretted instruments. The broadcasts ended in spring 1939 due to lackluster sales of instructional materials and other factors. String lessons returned in February 1950 and continued locally through the fall of 1951 over WUOM at the University of Michigan. These programs contributed to the development of school bands and orchestras in North America and hold implications for distance learning in music today.
Grief Instruments in Children and Adolescents: A Systematic Review
Authors: Zhang Toni , Krysinska Karolina , Alisic Eva , Andriessen Karl
Published: April 2023

Many children and adolescents experience the death of a close person, such as a family member or a friend. However, there is a scarcity of literature on the assessment of grief in bereaved youth. The use of validated instruments is essential to advance our knowledge of grief in children and adolescents. We conducted a systematic review, adhering to PRISMA guidelines, to identify instruments that measure grief in this population and explore their characteristics. Searches in six databases (Medline, PsycINFO, Embase, Emcare, Scopus, and Web of Science) identified 24 instruments, encompassing three categories: general-purpose grief scales, maladaptive grief scales, and specialized grief scales. We extracted data using a predetermined list of descriptive and psychometric properties. Findings indicate a need to direct research towards more stringent validation of existing instruments and the design of new instruments in line with developments in the understanding of grief in this population.
Brief Online Intervention Model Promotes Sustained Helping Behavior Across 6 Months Following a Population-Wide Traumatic Event
Authors: Balderas Jessica , Bistricky Steven L. , Gimenez-Zapiola Malena , Pascuzzi Bailey , Millmann Megan , Short Mary B.
Published: April 2023

Background: Following natural disasters, early helping behavior often dissipates despite remaining disaster-related suffering and affective vulnerability in the community. Interventions that have successfully increased helping behaviors have included components of motivational interviewing (MI) and mindful compassion; however, this research is limited by laboratory-based settings and lengthy training sessions. Brief, portable, and efficient intervention is needed to increase accessibility to large groups simultaneously. Method: The current study piloted a brief, online, self-administered MI and mindful compassion intervention administered 4–10 weeks post-Hurricane Harvey examining if it would sustain helping behaviors over the ensuing year. The study also examined potential moderators of the relationship between compassion for others and internalizing symptoms, and whether helping behaviors predicted post-traumatic stress symptoms. Results: The intervention group sustained the use of helping behaviors more than an active control group after 9–12 months. Also, compassion satisfaction and burnout moderated the relationship between compassion for others and post-traumatic stress and depressive symptoms at follow-up. Conclusions: Results suggest a potentially useful model of how an efficiently distributed intervention might sustain helping behaviors after a natural disaster and provide insight into possible longitudinal risk and protective factors for post-traumatic stress and depressive symptoms among helping volunteers.
Maternal Knowledge of Anemia and Adherence to its Prevention Strategies: A Health Facility-Based Cross-Sectional Study Design
Authors: Balcha Wondu Feyisa , Eteffa Tola , Arega Tesfu Azimeraw , Abeje Alemayehu Bezawit
Published: April 2023

Anemia is a largely preventable and curable medical disease if detected intime. This study aimed to assess maternal knowledge of anemia and its prevention strategies in the public health facilities of Pawi district, Northwest, Ethiopia. A health facility-based cross-sectional study was conducted from February 1/2020 to March 2/2020, among 410 antenatal care attendees in the public health facilities of the Pawi district. The data was collected by systematic random sampling technique and analyzed using SPSS 25.0 version. Logistic regression analyses were done to estimate the crude and adjusted odds ratio with a CI of 95% and a P-value of less than .05 considered statistically significant. Less than half, 184 (44.9%) [95% CI = 40.0-49.8] and almost half, 216 (52.7%) [95% CI = 47.8-57.5] of the pregnant women had good knowledge of anemia and good adherence to its prevention strategies respectively. Women who are found in the age group of 15 to 19, 20 to 24, and 25 to 29 years, rural residency, secondary, and above educational level, vaginal bleeding, third trimester of pregnancy, and medium and high minimum dietary diversification score were significantly associated with knowledge of anemia. On the other hand: women who are found in the age group of 15 to 19 years, secondary above educational level, primigravida women, having ≤2 and 3 to 4 family sizes, second and third trimester of pregnancy, high minimum dietary diversification score, and good knowledge of anemia were significantly associated with adherence to anemia prevention strategies. Maternal knowledge of anemia and adherence to its prevention strategies were low. Nutritional counseling on the consumption of iron-rich foods and awareness creation on the effects of anemia in pregnant women must be strengthened to increase the knowledge of anemia and adherence to its prevention strategies.
Preference Shifts During Health Shocks: Foreign Tourists’ Expenditure–Price Elasticity Throughout the Pandemic
Authors: Boto-García David , Baños Pino José Francisco
Published: April 2023

This study evaluates the changes in the expenditure–price elasticities of foreign tourists in the summer periods of 2019, 2020, and 2021. We first develop a theoretical characterization that combines microeconomic, loss aversion, price inequality and precautionary savings theories. Next, exploiting microdata for more than 34,000 foreign tourists visiting Spain, we estimate OLS and quantile regressions to empirically examine the expenditure elasticities with respect to the prices of transport services, leisure activities and bars and restaurants at the destination (17 regions). We find that (i) the expenditure–price elasticity of transportation (leisure activities) increases (decreases) during the pandemic, whereas that of bars and restaurants remains unchanged, (ii) foreign tourists are comparatively less expenditure–price elastic at high expenditure levels in transportation and bars and restaurants, and (iii) expenditure–price elasticities are highly heterogeneous depending on the origin country. Managerial and theoretical implications of the findings for firms’ pricing strategies are discussed.
Assessment of Strengths in Criminal Justice System-Impacted Youth: A Retrospective Validation Study of the SAPROF-YV
Authors: Finseth Sonia , Peterson-badali Michele , Brown Shelley L. , Skilling Tracey A.
Published: April 2023

The Structured Assessment of Protective Factors for Violence Risk-Youth Version (SAPROF-YV; de Vries Robbé et al., 2015) was designed specifically to assess strengths as a complement to risk assessment tools. We retrospectively examined its reliability and validity in 305 Canadian community-sentenced youth, both in the overall sample and in male and female, and Black and White, subgroups. In all groups, the total score had strong internal consistency, inter-rater reliability, and convergent validity, and significantly predicted general recidivism at 3-year fixed follow-up. The SAPROF-YV showed incremental validity over the YLS/CMI only in Black youth. In the total sample, a moderation effect was identified whereby strengths were protective at lower levels of risk but not for moderate or high risk youth. The SAPROF-YV shows promising reliability and validity; however, more research is needed before clear guidance can be provided regarding the use of this measure in clinical practice.