bluuebunny/crossref_metadata_2025 huggingface dataset:
Different Sourcing Point of Interest Matching Method Considering Multiple Constraints
Authors: Li Chengming , Liu Li , Dai Zhaoxin , Liu Xiaoli
Published: March 2020

Point of interest (POI) matching is critical but is the most technically difficult part of multi-source POI fusion. The accurate matching of POIs from different sources is important for the effective reuse of POI data. However, the existing research on POI matching usually adopts weak constraints, which leads to a low POI matching accuracy. To address the shortcomings of previous studies, this paper proposes a POI matching method with multiple determination constraints. First, according to various attributes (name, class, and spatial location), a new calculation model considering spatial topology, name role labeling, and bottom-up class constraints is established. In addition, the optimal threshold values corresponding to the different attribute constraints are determined. Second, according to the multiattribute constraint values and optimal thresholds, a constraint model with multiple strict determination constraints is proposed. Finally, actual POI data from Baidu Map and Gaode Map in Dongying city is used to validate the method. Comparing to the existing method, the accuracy and recall of the proposed method increase 0.3% and 7.1%, respectively. The experimental results demonstrate that the proposed POI matching method attains a high matching accuracy and high feasibility.
Psychological Impact of NBS for CF
Authors: Chudleigh Jane , Chinnery Holly
Published: March 2020

Newborn screening for cystic fibrosis has resulted in diagnosis often before symptoms are recognised, leading to benefits including reduced disease severity, decreased burden of care, and lower costs. The psychological impact of this often unsought diagnosis on the parents of seemingly well children is less well understood. The time during which the screening result is communicated to families but before the confirmatory test results are available is recognised as a period of uncertainty and it is this uncertainty that can impact most on parents. Evidence suggests this may be mitigated against by ensuring the time between communication and confirmatory testing is minimized and health professionals involved in communicating positive newborn screening results and diagnostic results for cystic fibrosis to families are knowledgeable and able to provide appropriate reassurance. This is particularly important in the case of false positive results or when the child is given a Cystic Fibrosis Screen Positive, Inconclusive Diagnosis designation. However, to date, there are no formal mechanisms in place to support health professionals undertaking this challenging role, which would enable them to meet the expectations set out in specific guidance.
Dynamic Estimation of Saturation Flow Rate at Information-Rich Signalized Intersections
Authors: Wang Yi , Rong Jian , Zhou Chenjing , Gao Yacong
Published: March 2020

Intersections are the bottlenecks of the road network. The capacity of signalized intersections restricts the operation of the road network. Dynamic estimation of capacity is necessary for signalized intersections refined management. With the development of technology, more and more detectors were installed near the intersection. It had been the information-rich environment, which provided support for dynamic estimation of capacity. A dynamic estimation method for a saturation flow rate based on a neural network was developed. It would grasp the dynamic change of saturation flow rates and influencing factors. The measure data at three scenarios (through lanes, shared right-turn and through lanes, shared left-turn and through lanes) of signalized intersections in Beijing were taken as examples to validate the proposed method. Firstly, the traffic flow characteristics of the three scenarios and factors affecting the saturation flow rate were analyzed. Secondly, neural network models of the three scenarios were established. Then the hyperparameters of neural network models were determined. After training, the neural network structure and parameters were saved. Lastly, the test set data was validated by the training model. At the same time, the proposed method was compared with the Highway Capacity Manual (HCM) method and the statistical regression method. The results show that both regression models and neural network models have better accuracy than HCM models. In a simple scenario, the neural network models are not much different from the regression models. With the increase of complexity of scenarios, the advantages of neural network models are highlighted. In through-left lane and through-right lane scenarios, the estimated saturation flow rates used by the proposed method were 7.02%, 4.70%, respectively. In the complexity of traffic scenarios, the proposed method can estimate the saturation flow rate accurately and timely. The results could be used for signal control schemes optimizing and operation managing at signalized intersections subtly.
Ontology-Mediated Historical Data Modeling: Theoretical and Practical Tools for an Integrated Construction of the Past
Authors: Travé Allepuz Esther , del Fresno Bernal Pablo , Mauri Martí Alfred
Published: March 2020

Building upon the concepts of constructed past theory, this paper introduces the outcome of ontology-mediated data modeling developed by the authors within the last 15 years. Assuming that the past is something constructed through reflection of former times, one of our major concerns is guaranteeing the traceability of the construction process of an integrated historical discourse built from all available sources of information, regardless of their origin or nature. Therefore, by means of defining key concepts such as ‘unit of topography’ and ‘actor’, we created an information system for data gathering and exploitation and applied it to some experiences of construction of the past. When applied within the archaeological domain, the result is an archaeological information system interoperable with other sources of historical information. Its strength is that it ensures the traceability of the process from the beginning avoiding the introduction and repetition of errors within the system. Along with the main case example developed in this paper, we also summarize some other data modeling examples within the same conceptual framework.
An Innovative Acoustic Rain Gauge Based on Convolutional Neural Networks
Authors: Avanzato Roberta , Beritelli Francesco
Published: March 2020

An accurate estimate of rainfall levels is fundamental in numerous application scenarios: weather forecasting, climate models, design of hydraulic structures, precision agriculture, etc. An accurate estimate becomes essential to be able to warn of the imminent occurrence of a calamitous event and reduce the risk to human beings. Unfortunately, to date, traditional techniques for estimating rainfall levels present numerous critical issues. The algorithm applies the Convolution Neural Network (CNN) directly to the audio signal, using 3 s sliding windows with an offset of only 100 milliseconds. Therefore, by using low cost and low power hardware, the proposed algorithm allows implementing critical high rainfall event alerting mechanisms with short response times and low estimation errors. More specifically, this paper proposes a new approach to rainfall estimation based on the classification of different acoustic timbres that rain produces at different intensities and on CNN. The results obtained on seven classes ranging from “No rain” to “Cloudburst” indicate an average accuracy of 75%, which rises to 93% if the misclassifications of the adjacent classes are not considered. Some application contexts concern smart cities for which the integration of an audio sensor inside the luminaire of a street lamp is foreseen, precision agriculture, as well as highway safety, by minimizing the risks of aquaplaning.
Supporting Drivers of Partially Automated Cars through an Adaptive Digital In-Car Tutor
Authors: Boelhouwer Anika , van den Beukel Arie Paul , van der Voort Mascha C. , Verwey Willem B. , Martens Marieke H.
Published: March 2020

Drivers struggle to understand how, and when, to safely use their cars’ complex automated functions. Training is necessary but costly and time consuming. A Digital In-Car Tutor (DIT) is proposed to support drivers in learning about, and trying out, their car automation during regular drives. During this driving simulator study, we investigated the effects of a DIT prototype on appropriate automation use and take-over quality. The study had three sessions, each containing multiple driving scenarios. Participants needed to use the automation when they thought that it was safe, and turn it off if it was not. The control group read an information brochure before driving, while the experiment group received the DIT during the first driving session. DIT users showed more correct automation use and a better take-over quality during the first driving session. The DIT especially reduced inappropriate reliance behaviour throughout all sessions. Users of the DIT did show some under-trust during the last driving session. Overall, the concept of a DIT shows potential as a low-cost and time-saving solution for safe guided learning in partially automated cars.
Hidden Genetic Variability, Can the Olive Moth Prays oleae (Lepidoptera: Yponomeutidae or Praydidae?) be a Species’ Complex?
Authors: Pazian Marlon , Nobre Tânia , Blibech Imen , Rei Fernando T
Published: March 2020

Prays oleae is the second most important pest in Mediterranean olive groves, causing substantial damage on olive production. We used mitochondrial [cytochrome c oxidase subunit I (COI), and NADH dehydrogenase subunit 5 (nad5)] and nuclear [ribosomal protein S5 (RpS5)] amplicons to assess the population variability in five main olive producing regions from Tunisia, to support or dismiss the existence of two non-monophyletic groups within the species, as found within Portugal. Our phylogenetic analysis with cytochrome c oxidase subunit I (COI) indeed displayed two distinct and well-supported clades of P. oleae, which were corroborated by the haplotype network reconstructed with both mitochondrial and nuclear amplicons. We were also able to dismiss the hypothesis that one of the clades would not develop on olive fruits. No correlation was observed between clades differentiation and geographic distribution. The existence of cryptic species can impact on the management of agroecosystems and on the perception of how these moths responds to environmental changes.
Effect of Supplemental Protease on Growth Performance and Excreta Microbiome of Broiler Chicks
Authors: Lourenco Jeferson M. , Nunn S. Claire , Lee Eliza. J. , Dove C. Robert , Callaway Todd R. , Azain Michael J.
Published: March 2020

One-day-old chicks were assigned one of four dietary treatments in a 2 × 2 factorial design in which the main effects were diet (adequate vs. low protein) and the addition of protease (0 vs. 200 g/1000 kg of feed). Chick performance (days 0–14) was recorded and their excreta were analyzed for short chain fatty acids, ammonia, and composition of the microbiota using 16S rRNA gene sequencing. Birds fed the low protein diet had lower body weight gain and poorer overall feed conversion ratio (FCR) (p ≤ 0.04); however, these parameters were not affected by the inclusion of protease (p ≥ 0.27). Protease inclusion did not affect any particular bacterial genus in the excreta, but it increased the total number of observed OTUs (p = 0.04) and Faith’s phylogenetic diversity (p = 0.05). Abundance of Proteus and Acinetobacter were lower in the excreta of chicks fed the low protein diet (p = 0.01). Abundance of Bacteroides was associated with poorer FCR, while Proteus was associated with improved FCR (p ≤ 0.009). Although diet had a stronger impact than protease on chick performance, both diet and protease yielded some changes in the intestinal microbiotas of the birds.
The Microbiota–Gut–Brain Axis Heart Shunt Part I: The French Paradox, Heart Disease and the Microbiota
Authors: Obrenovich Mark , Siddiqui Bushra , McCloskey Benjamin , Reddy V. Prakash
Published: March 2020

It has been well established that a vegetarian and polyphenol-rich diet, including fruits, vegetables, teas, juices, wine, indigestible fiber and whole grains, provide health-promoting phytochemicals and phytonutrients that are beneficial for the heart and brain. What is not well-characterized is the affect these foods have when co-metabolized within our dynamic gut and its colonizing flora. The concept of a heart shunt within the microbiota-gut-brain axis underscores the close association between brain and heart health and the so-called “French paradox” offers clues for understanding neurodegenerative and cerebrovascular diseases. Moreover, oxidation-redox reactions and redox properties of so-called brain and heart-protective foods are underappreciated as to their enhanced or deleterious mechanisms of action. Focusing on prodromal stages, and common mechanisms underlying heart, cerebrovascular and neurodegenerative diseases, we may unmask and understanding the means to better treat these related diseases.
The Microbiota–Gut–Brain Axis–Heart Shunt Part II: Prosaic Foods and the Brain–Heart Connection in Alzheimer Disease
Authors: Obrenovich Mark , Tabrez Shams , Siddiqui Bushra , McCloskey Benjamin , Perry George
Published: March 2020

There is a strong cerebrovascular component to brain aging, Alzheimer disease, and vascular dementia. Foods, common drugs, and the polyphenolic compounds contained in wine modulate health both directly and through the gut microbiota. This observation and novel findings centered on nutrition, biochemistry, and metabolism, as well as the newer insights we gain into the microbiota-gut-brain axis, now lead us to propose a shunt to this classic triad, which involves the heart and cerebrovascular systems. The French paradox and prosaic foods, as they relate to the microbiota-gut-brain axis and neurodegenerative diseases, are discussed in this manuscript, which is the second part of a two-part series of concept papers addressing the notion that the microbiota and host liver metabolism all play roles in brain and heart health.
Ore Geology, Fluid Inclusions, and (H-O-S-Pb) Isotope Geochemistry of the Sediment-Hosted Antimony Mineralization, Lyhamyar Sb Deposit, Southern Shan Plateau, Eastern Myanmar: Implications for Ore Genesis
Authors: Min Oo Aung , Xinbiao Lv , Zaw Khin , Htay Than , Binke Sun , Mohammed Abdalla Adam Munir
Published: March 2020

The Lyhamyar deposit is a large Sb deposit in the Southern Shan Plateau, Eastern Myanmar. The deposit is located in the Early Silurian Linwe Formation, occurring as syntectonic quartz-stibnite veins. The ore body forms an irregular staircase shape, probably related to steep faulting. Based on the mineral assemblages and cross-cutting relationships, the deposit shows two mineralization stages: (1) the pre-ore sedimentary and diagenetic stage, and (2) the main-ore hydrothermal ore-forming stage (including stages I, II, and III), i.e., (i) early-ore stage (stage I) Quartz-Stibnite, (ii) late-ore stage (stage II) Quartz-calcite-Stibnite ± Pyrite, and (iii) post-ore stage (stage III) carbonate. The ore-forming fluid homogenization temperatures from the study of primary fluid inclusions in quartz and calcite indicate that the ore-forming fluid was of a low temperature (143.8–260.4 °C) and moderate to high-salinity (2.9–20.9 wt. % NaCl equivalent). Hydrogen and oxygen isotopes suggest that the ore-forming fluids of the Lyhamyar deposit were derived from circulating meteoric water mixed with magmatic fluids that underwent isotopic exchange with the surrounding rocks. Sulfur in Lyhamyar was dominated by thermochemical sulfate reduction (TSR) with dominant magmatic source sulfur. The lead isotope compositions of the stibnite indicate that the lead from the ore-forming metals was from the upper crustal lead reservoir and orogenic lead reservoir. On the basis of the integrated geological setting, ore geology, fluid inclusions, (H-O-S-Pb) isotope data, and previous literature, we propose a new ore-deposit model for the Lyhamyar Sb deposit: It was involved in an early deposition of pyrite in sedimentary and diagenetic stages and later Sb mineralization by mixing of circulating meteoric water with ascending magmatic fluids during the hydrothermal mineralization stage.
Types of Xenogenic Olivine from Siberian Kimberlites
Authors: Tychkov Nikolay S. , Agashev Alexey M. , Pokhilenko Nikolay P. , Tsykh Vladimir A. , Sobolev Nikolay V.
Published: March 2020

This work is devoted to the systematization of the composition of xenogenic olivine from kimberlites as the main mineral composing the lithospheric mantle. Based on data on the composition of olivines from xenoliths and megacrysts from kimberlites, a general division into four types is proposed: olivines of ultrahigh-temperature (HTP-1), high-temperature (HTP-2) and low-temperature (LTP) peridotites, as well as olivines of low-chromium megacryst association (MCA). The separation scheme uses the CaO content as an indicator of the formation temperature and the Mg/(Mg + Fe) ratio as an indicator of the degree of enrichment in olivines. In contrast to Al, the Ca content in olivines from cratonic peridotites is high enough to use only EPMA when applying the proposed scheme. According to this scheme the study of more than 1500 individual olivine xenocrysts from a number of kimberlite bodies of the Siberian platform was made. It revealed three characteristic distributions of olivine types: without high-temperature differences (Obnazhennaya pipe), with significant development of HTP-2 (Olivinovaya and Vtorogodnitsa pipes), and with a significant development of HTP-1 (Dianga pipe). Only the latter type of distribution is characterized by the presence of a noticeable amount of megacryst association olivines. The study of other minor elements (TiO2 and NiO) in olivines allowed us to propose a model for the formation of high-temperature olivines of two different types due to the interaction of megacryst melt of various fractionation stages on depleted rocks of the lithospheric mantle. HTP-2 olivines arose upon exposure to a fractionated melt of the late stages of crystallization, and HTP-1 olivines appeared upon exposure to unfractionated (less enriched with incompatible components) megacryst melt at higher temperatures of the initial stage of crystallization.
Structure and Behavior of the Ni End-Member Schreibersite Ni3P under Compression to 50 GPa
Authors: Chornkrathok Sasithorn , Zhang Dongzhou , Dera Przemyslaw
Published: March 2020

To better understand the potential presence of light element alloys of Fe and Ni in the Earth’s interior, the crystal structure and compressional behavior of the Ni-P binary compound, schreibersite (Ni3P), have been investigated using synchrotron X-ray diffraction experiments. Both powder and two single-crystal samples of synthetic Ni3P (in different orientations with respect to the loading axis of the diamond anvil cell) were compressed up to approximately 50 GPa at ambient temperature. The compressional data obtained for Ni3P were fitted with a 3rd order Birch–Murnaghan equation of state. All data indicated that the c/a ratio of unit cell parameters remained approximately constant up to about 30 GPa but then increased progressively with pressure, exhibiting a second slight discontinuity at approximately 40 GPa. The changes in unit cell parameters at ~30 GPa and ~40 GPa suggested discontinuous changes in magnetic ordering. Moreover, the threshold of these subtle discontinuities is sensitive to the stress state and orientation of the crystal in the diamond anvil cell. This study is the first report on the compressional behavior of both powder and single-crystal schreibersite at high-pressure (up to 50 GPa). It offers insights into the effects of Ni3P components on the compressional behavior of the Earth’s core.
Distribution of Uranium and Rare Elements in Radioactive Phosphate-Bearing Anomalies in Southeast Mongolia
Authors: Vakanjac Boris , Rutherford Neil , Ristić Vakanjac Vesna , Đumić Tanita , Đorđević Milošević Suzana
Published: March 2020

Soviet and Mongolian geologists initiated geological exploration of Mongolia for minerals after World War II (1945). These activities lasted until the breakup of the USSR in 1991. As part of this exploration systematic uranium and rare element exploration was undertaken across Mongolia. New exploration resumed in Mongolia at the beginning of the 21st century for a range of ore and mineral deposit styles including uranium, coal, base and precious metals and Fe-ore. This was generally undertaken by Western-based companies. This paper presents the results from regional reassessment by company exploration in 2011 for uranium radiometric anomalism found during the early Soviet investigations located north of Sainshand Provincial City and the results of preliminary prospecting studies near the town of Mandakh, both in southeastern Mongolia. These radioactive sites are characterized by elevated phosphate–uranium-rare element abundance. The primary company exploration objective of the new study was to confirm and characterize the anomalies and investigate in more detail the concentration of uranium and rare elements at these sites and assess the economic potential for their exploitation. A secondary objective based on the results from radiochemistry and rare element content was to highlight the potential environmental impact on livestock pastoral activities and wellbeing of nomadic families who graze their stock over the anomalous zones in the region. The source of most of the anomalism is considered derived from erosion and subsequent transport in solution or in heavy minerals from extensively eroded granites and mafic magmas of various ages into graben basins and drainage depressions in the windswept arid terrain. The economic potential of the sites explored was considered too low to be of exploration interest. The anomalism does require characterization for environmental health and safety purposes, given sheep, goats, camels and other livestock traditionally bred in Mongolia are grazing on the enriched pasture and nomadic people reside on, or in their vicinity of elevated zones of radiometric anomalism from anomalous uranium, radon and radium held in phosphorus enriched soils.
Structure and Phase Changes of Nickel Slag in Oxidation Treatment
Authors: Li Xiaoming , Zhang Xinyi , Zang Xuyuan , Xing Xiangdong
Published: March 2020

To overcome the difficulty in the direct reduction of Fe2SiO4 in nickel slag, the isothermal oxidation of the nickel slag was conducted between 300 and 1000 °C. Its morphology and phase composition after oxidation at 300–1000 °C for 5–30 min are analyzed by means of Scanning electron microscopy, X-ray diffraction, and thermodynamic calculation. The results show that oxidation can effectively promote the transformation of Fe2+ into Fe3+ in nickel slag. At 900 °C, the oxidation rate of element Fe reaches 95%. Fe2+ in Fe2SiO4 is oxidized to generate Fe2O3, and the unit cell volume decreases from 301.75 Å3 to 297.72 Å3 with the increase in temperature. At the same time, a large number of pores appear in the particle, which reduces the mass transfer resistance of gas in the particle during the reduction process, accelerates the reduction speed, and is conducive to strengthening the reduction. Therefore, the oxidation treatment of nickel slag can improve its phase composition, thus benefiting the subsequent reduction.
Titania Nanofluids Based on Natural Ester: Cooling and Insulation Properties Assessment
Authors: Olmo Cristian , Méndez Cristina , Ortiz Félix , Delgado Fernando , Ortiz Alfredo
Published: March 2020

The assessment of a TiO2 vegetal-based dielectric nanofluid has been carried out, and its characteristics and behavior have been tested and compared with a previously tested maghemite nanofluid. The results obtained reflect a similar affectation of the main properties, with a maximal improvement of the breakdown voltage of 33% at 0.5 kg/m3, keeping the thermal conductivity and the viscosity almost constant, especially the first one. This thermal characterization agrees with the results obtained when applying the TiO2 optimal nanofluid in the cooling of an experimental setup, with a slightly worse performance than the base fluid. Nevertheless, this performance is the opposite to that noticed with the ferrofluid, which was capable of improving the cooling of the transformer and decreasing its temperature. The similarities between the characterizations of both nanofluids, the differences in their cooling performances and their different magnetic natures seem to point out the presence of additional thermomagnetic buoyancy forces to support the improvement of the cooling.
Dry Generation of CeO2 Nanoparticles and Deposition onto a Co-Culture of A549 and THP-1 Cells in Air-Liquid Interface—Dosimetry Considerations and Comparison to Submerged Exposure
Authors: Cappellini Francesca , Di Bucchianico Sebastiano , Karri Venkatanaidu , Latvala Siiri , Malmlöf Maria , Kippler Maria , Elihn Karine , Hedberg Jonas , Odnevall Wallinder Inger , Gerde Per , Karlsson Hanna L.
Published: March 2020

Relevant in vitro assays that can simulate exposure to nanoparticles (NPs) via inhalation are urgently needed. Presently, the most common method employed is to expose lung cells under submerged conditions, but the cellular responses to NPs under such conditions might differ from those observed at the more physiological air-liquid interface (ALI). The aim of this study was to investigate the cytotoxic and inflammatory potential of CeO2 NPs (NM-212) in a co-culture of A549 lung epithelial cells and differentiated THP-1 cells in both ALI and submerged conditions. Cellular dose was examined quantitatively using inductively coupled plasma mass spectrometry (ICP-MS). The role of serum and LPS-priming for IL-1β release was further tested in THP-1 cells in submerged exposure. An aerosol of CeO2 NPs was generated by using the PreciseInhale® system, and NPs were deposited on the co-culture using XposeALI®. No or minor cytotoxicity and no increased release of inflammatory cytokines (IL-1β, IL-6, TNFα, MCP-1) were observed after exposure of the co-culture in ALI (max 5 µg/cm2) or submerged (max 22 µg/cm2) conditions. In contrast, CeO2 NPs cause clear IL-1β release in monocultures of macrophage-like THP-1, independent of the presence of serum and LPS-priming. This study demonstrates a useful approach for comparing effects at various in-vitro conditions.
Design of Experiments-Assisted Development of Clotrimazole-Loaded Ionic Polymeric Micelles Based on Hyaluronic Acid
Authors: Catenacci Laura , Marrubini Giorgio , Sorrenti Milena , Rossi Silvia , Sandri Giuseppina , Ferrari Franca , Fagnani Valentina , Valentino Caterina , Bonferoni Maria Cristina
Published: March 2020

Polymeric micelles based on amphiphilic polysaccharides have some advantages as a carrier of poorly soluble lipophilic drugs thanks to their characteristic "core–shell" structure. Previously, ionic polymeric micelles based on chitosan and fatty acids have been developed. The aim of the present study was the preparation and characterization of hyaluronic acid (HA) derivatives by direct ionic interaction between the HA carboxylic groups and the amine groups of dodecyl amine (DDA) and hexadecyl amine (HDA). The HA–HDA polymeric micelles were loaded with a poorly soluble hydrophobic antifungal drug, clotrimazole (CLO). A 23 full factorial experimental design was used to evaluate the effect of the following factors: HA/HDA ratio from 1:0.25 to 1:0.75, cholesterol (CHOL%) as percentage of HA from 10% to 30%, and preparation temperature from 20 to 40 °C. As dependent variables (responses), nanoparticle dimensions and clotrimazole concentration in the final colloidal dispersion were considered. To optimize the drug final concentration, the design was therefore expanded into a rotatable central composite design (CCD). The effects of the formulation variables and the composition of the optimized formulation were confirmed by a mixture design. Physicochemical characterization of the optimized formulation was performed, confirming the ionic interaction between the polysaccharide and the HDA.
Nanoarchitectonics of Nanoporous Carbon Materials in Supercapacitors Applications
Authors: Shrestha Rekha Goswami , Maji Subrata , Shrestha Lok Kumar , Ariga Katsuhiko
Published: March 2020

High surface area and large pore volume carbon materials having hierarchical nanoporous structure are required in high performance supercapacitors. Such nanoporous carbon materials can be fabricated from organic precursors with high carbon content, such as synthetic biomass or agricultural wastes containing cellulose, hemicellulose, and lignin. Using recently developed unique concept of materials nanoarchitectonics, high performance porous carbons with controllable surface area, pore size distribution, and hierarchy in nanoporous structure can be fabricated. In this review, we will overview the recent trends and advancements on the synthetic methods for the production of hierarchical porous carbons with one- to three-dimensional network structure with superior performance in supercapacitors applications. We highlight the promising scope of accessing nanoporous graphitic carbon materials from: (i) direct conversion of single crystalline self-assembled fullerene nanomaterials and metal organic frameworks, (ii) hard- and soft-templating routes, and (iii) the direct carbonization and/or activation of biomass or agricultural wastes as non-templating routes. We discuss the appealing points of the different synthetic carbon sources and natural precursor raw−materials derived nanoporous carbon materials in supercapacitors applications.
Efficiency of Differently Processed Membranes Based on Cellulose as Cationic Dye Adsorbents
Authors: Maleš Laura , Fakin Darinka , Bračič Matej , Gorgieva Selestina
Published: March 2020

In order to minimize the pollution caused by the reuse of textile dyes, technologies and materials have been developed that purify waste water in an efficient and cost-effective manner before it is discharged into a water body. In this context, the presented research investigates the potential of two types of fully cellulose-based membranes as adsorbents for cationic dyes used in the textile industry. The first type combines cellulose nanofibrils (CNFs) and carboxymethylated cellulose (CMC) using the solvent casting process and an esterification coupling reaction, while the second type uses commercial bacterial cellulose (BC) in a native and sodium periodate-treated form (BCox). The corresponding membranes were comprehensively evaluated by means of Fourier Transform Infrared (FTIR) Spectroscopy. Results confirm the esterification process within the CNF/CMC membranes, as well as BC oxidation after periodate treatment, as shown by bands at 1726.2 cm−1 and 895 cm−1, respectively. The Potentiometric Titration shows the highest total negative charge of 1.07 mmol/g for 4CNF/4CMC, which is assigned to the presence of COO− within CMC polymers, and lowest (0.21 mmol/g) for BCox. The Contact Angle Goniometry data confirm the hydrophilicity of all membranes, and the angle increased from 0 ° (in pure BC) to 34.5 ° in CMC-rich and to 31.4 ° in BCox membranes due to the presence of CH2COO− and CHO groups, respectively. Confocal Fluorescent Microscopy (CFM) demonstrated the highest µ-roughness in 4CNF/4CMC, while Scanning Electron Microscopy (SEM) depicted diverse morphological features between the membranes, from ultrafine nanofiber networks (in BC and BCox) to larger fiber bundles connected within the polymer phase in CNF/CMC membranes. The adsorption experiment followed by UV–VIS spectroscopy, showed ~100% dye removal efficiency in both CNF/CMC-based membranes, while BC and BCox adsorbed only 24.3% and 23.6%, respectively, when anthraquinone dye was used. Azo dye was only adsorbed with an efficiency of 7–9% on CMC/CNF-based membranes, compared with 5.57% on BC and 7.33% on BCox membranes. The adsorption efficiency at equilibrium was highest for BC (1228 mg/g) and lowest for 7CNF/1CMC (419.24 mg/g) during anthraquinone dye adsorption. In the case of azo dye, the BCox was most effective, with 445.7 mg/g. Applicability of a pseudo second-order model was confirmed for both dyes and all membranes, except for BCox in combination with azo dye, showing the fastest adsorption rate in the case of the 7CNF/1CMC membrane.
Light-Activated Heterostructured Nanomaterials for Antibacterial Applications
Authors: Mutalik Chinmaya , Wang Di-Yan , Krisnawati Dyah Ika , Jazidie Achmad , Yougbare Sibidou , Kuo Tsung-Rong
Published: March 2020

An outbreak of a bacterial contagion is a critical threat for human health worldwide. Recently, light-activated heterostructured nanomaterials (LAHNs) have shown potential as antibacterial agents, owing to their unique structural and optical properties. Many investigations have revealed that heterostructured nanomaterials are potential antibacterial agents under light irradiation. In this review, we summarize recent developments of light-activated antibacterial agents using heterostructured nanomaterials and specifically categorized those agents based on their various light harvesters. The detailed antibacterial mechanisms are also addressed. With the achievements of LAHNs as antibacterial agents, we further discuss the challenges and opportunities for their future clinical applications.
Environmental Influences on Dietary Intake of Children and Adolescents
Authors: Gubbels Jessica S.
Published: March 2020

Childhood is a crucial period for establishing lifelong healthy nutritional habits [...]
MK-7 and Its Effects on Bone Quality and Strength
Authors: Sato Toshiro , Inaba Naoko , Yamashita Takatoshi
Published: March 2020

Vitamin K acts as a cofactor and is required for post-translational γ-carboxylation of vitamin K-dependent proteins (VKDP). The current recommended daily intake (RDI) of vitamin K in most countries has been established based on normal coagulation requirements. Vitamin K1 and menaquinone (MK)-4 has been shown to decrease osteocalcin (OC) γ-carboxylation at RDI levels. Among the several vitamin K homologs, only MK-7 (vitamin K2) can promote γ-carboxylation of extrahepatic VKDPs, OC, and the matrix Gla protein at a nutritional dose around RDI. MK-7 has higher efficacy due to its higher bioavailability and longer half-life than other vitamin K homologs. As vitamin K1, MK-4, and MK-7 have distinct bioactivities, their RDIs should be established based on their relative activities. MK-7 increases bone mineral density and promotes bone quality and strength. Collagen production, and thus, bone quality may be affected by MK-7 or MK-4 converted from MK-7. In this review, we comprehensively discuss the various properties of MK-7.
Non-Human Primate Models of Dengue Virus Infection: A Comparison of Viremia Levels and Antibody Responses during Primary and Secondary Infection among Old World and New World Monkeys
Authors: Muhammad Azami Nor Azila , Takasaki Tomohiko , Kurane Ichiro , Moi Meng Ling
Published: March 2020

Due to the global burden of dengue disease, a vaccine is urgently needed. One of the key points in vaccine development is the development of a robust and reliable animal model of dengue virus infection. Characteristics including the ability to sustain viral replication, demonstration of clinical signs, and immune response that resemble those of human dengue virus infection are vital in animal models. Preclinical studies in vaccine development usually include parameters such as safety evaluation, induction of viremia and antigenemia, immunogenicity, and vaccine effectiveness. Although mice have been used as a model, non-human primates have an advantage over mice because of their relative similarity to humans in their genetic composition and immune responses. This review compares the viremia kinetics and antibody responses of cynomolgus macaques (Macaca fasicularis), common marmosets (Callithrix jacchus), and tamarins (Saguinus midas and Saguinus labitus) and summarize the perspectives and the usefulness along with challenges in dengue vaccine development.
Histochemical and Microscopic Studies Predict that Grapevine Genotype “Ju mei gui” is Highly Resistant against Botrytis cinerea
Authors: Rahman Mati Ur , Ma Qingqing , Ahmad Bilal , Hanif Muhammad , Zhang Youlin
Published: March 2020

The necrotrophic fungus Botrytis cinerea causes devastating pre- and post-harvest yield losses in grapevine (Vitis vinifera L.). Although B. cinerea has been well-studied in different plant species, there is limited information related to the resistance and susceptibility mechanisms of Vitis genotypes against B. cinerea infection. In the present study, leaves and berries of twenty four grape genotypes were evaluated against B. cinerea infection. According to the results, one genotype (Ju mei gui) was highly resistant (HR), one genotype (Kyoho) was resistant (R), eight genotypes were susceptible (S), and fourteen genotypes were highly susceptible (HS) against infection of B. cinerea in leaves. Whereas in the case of B. cinerea infection in grape berry, three genotypes were found to be highly resistant, three resistant, eleven genotypes susceptible, and seven were highly susceptible. To further explore the mechanism of disease resistance in grapevine, we evaluated “Ju mei gui” and “Summer black” in terms of B. cinerea progression, reactive oxygen species reactions, jasmonic acid contents, and the activities of antioxidant enzymes in leaf and fruit. We surmise that the resistance of “Ju mei gui” is due to seized fungal growth, minor reactive oxygen species (ROS) production, elevated antioxidant enzyme activity, and more jasmonic acid (JA) contents. This study provides insights into the resistance and susceptibility mechanism of Vitis genotypes against B. cinerea. This will help for the selection of appropriate germplasm to explore the molecular basis of disease resistance mechanisms in grapevine.
T.E.A.M.S.Work: Leveraging Technicians to Enhance ABM Med Sync in Community Pharmacies
Authors: Hughes Tamera D. , Minshew Lana M. , Cutrell Stacey , Ferreri Stefanie P.
Published: March 2020

The expansion of pharmacy technicians’ roles in community pharmacies allows pharmacists the opportunity to focus on providing clinical services to patients. This study explores the tasks pharmacy technicians’ perform to support Med Sync programs in community pharmacies. Pharmacy staff members at North Carolina pharmacies with more than fifty percent of their prescription volume being dispensed as part of a Med Sync program were recruited to participate in semi-structured interviews. Inductive coding and summary analysis were used to analyze the interview data. Study participants described pharmacy technicians’ roles in identifying patients for marketing and enrollment, reviewing patients’ medications list, choosing alignment dates based on patient preference, contacting patients in preparation for dispensing and, lastly, engaging in pickup or delivery of medications. This study highlights technicians’ vital role in completing tasks that support Med Sync programs in community pharmacies.
A Comprehensive Evaluation of Studies on the Adverse Effects of Medications in Australian Aged care Facilities: A Scoping Review
Authors: Qasim Haider , Simpson Maree , Guisard Yann , de Courten Barbora
Published: March 2020

Aim: this scoping review was designed to identify studies that assess adverse drug reactions (ADRs) for older people in Australian aged care facilities. This review critically evaluates each published study to identify the risk of, or actual, adverse drug events in older people. Inclusion criteria: this review considered any clinical studies that examined the adverse effects of medications in older people who were living in aged care facilities. This review considered qualitative studies, analytical studies, randomized controlled trials (RCTs), descriptive cross-sectional studies, and analytic observational studies that explored the use of medications and their adverse effects on older people in clinical settings (including aged care facilities). Methods: an initial search of the PubMed (United State National Library of Medicine), OvidSP, EBSCOHost, ScienceDirect, Wiley Online, SAGE, and SCOPUS databases, with full text was performed, followed by an analysis of the article’s title and abstract. Additionally, MeSH (Medical Subject Headings) was used to describe the article. The initial round of the database search was based on inclusion criteria from studies that assessed tools or protocols aiming to identify the adverse effects of medications on the elderly population suffering chronic conditions or multiple co-morbidities. Two reviewers screened the retrieved papers for inclusion. The data presented in this review are in tabular forms and accompanied by a narrative summary which aligns with the review’s objectives. Results: seven studies were identified, and the extracted data from these studies were grouped according their characteristics and the auditing results of each study. Conclusion: it would be beneficial to design a comprehensive or broadly adverse drug reaction assessment tool derived from Australian data that has been used on the elderly in an Australian healthcare setting.
Vesiculation of Red Blood Cells in the Blood Bank: A Multi-Omics Approach towards Identification of Causes and Consequences
Authors: Freitas Leal Joames K. , Lasonder Edwin , Sharma Vikram , Schiller Jürgen , Fanelli Giuseppina , Rinalducci Sara , Brock Roland , Bosman Giel
Published: March 2020

Microvesicle generation is an integral part of the aging process of red blood cells in vivo and in vitro. Extensive vesiculation impairs function and survival of red blood cells after transfusion, and microvesicles contribute to transfusion reactions. The triggers and mechanisms of microvesicle generation are largely unknown. In this study, we combined morphological, immunochemical, proteomic, lipidomic, and metabolomic analyses to obtain an integrated understanding of the mechanisms underlying microvesicle generation during the storage of red blood cell concentrates. Our data indicate that changes in membrane organization, triggered by altered protein conformation, constitute the main mechanism of vesiculation, and precede changes in lipid organization. The resulting selective accumulation of membrane components in microvesicles is accompanied by the recruitment of plasma proteins involved in inflammation and coagulation. Our data may serve as a basis for further dissection of the fundamental mechanisms of red blood cell aging and vesiculation, for identifying the cause-effect relationship between blood bank storage and transfusion complications, and for assessing the role of microvesicles in pathologies affecting red blood cells.
The Relationship between the Economic Strand of Contemporary Pentecostalism and Neo-Liberalism in Post-1994 South Africa
Authors: Kgatle Mookgo Solomon
Published: March 2020

South Africa endured racial segregation under the national party for many years until 1994, with the attainment of democracy. In the process of negotiating a democracy like the CODESA negotiations, the ANC-led government found itself adopting economic policies that embraced neo-liberalism, which later became unfavorable to the black majority in South Africa. Consequently, although these economic policies of the post-colonial South Africa have made a few black people rich, many still live under the triple socio-economic challenges like unemployment, poverty, and inequality. In addition to the triple challenges, many people still lack basic needs like water, sanitation, food, clothing, and shelter. This paper is a discourse on the relationship between contemporary Pentecostalism and neo-liberalism in South Africa. Given their economic standing, the paper seeks to demonstrate that contemporary South African Pentecostalism has potential to become an alternative economic reform.
Identity Encounters in Public Spaces—Military Service as a Legally Binding Public Space. The Case of Women’s Singing in the Israel Defense Forces
Authors: Umiel-Feldman Shani
Published: March 2020

The term ‘Public Sphere’ is used to distinguish it from the private. Here, we will use the term ‘Public Spaces’ to distinguish between various types of public spheres, differing from one another not only in their controlling identity, but also in the level of obligation to be in them and the extent in which they demand obedience from their participants. The new typology proposed in this paper conceptualizes the Israel Defense Forces [IDF] as a legally binding Public Space, using the case study of the Jewish religious law prohibiting Orthodox men to listen to a woman’s singing voice. This prohibition has sparked a strong public controversy and ongoing clashes between the army and religion. The case study illustrates a wide range of confrontations over the identity of the IDF’s space. While examining similar cases in other armies around the world, the paper presents a model explaining the terms and conditions for disputes on the nature of Public Spaces around the world, and when to expect confrontations between identities in different Public Spaces. Finally, the paper attempts to predict the extent and scope of such confrontations, on four dimensions: (a) The level of obligation to be in the Public Space; (b) the level of greediness of the Public Space; (c) the level of heterogeneity of identities within the Public Space; and (d) the level of personal identity greediness of persons and groups whose identity differs from the hegemonic identity in the public space.
Painting Practical Support: A Study about the Usage of Painting Materials in Children’s Painting Works
Authors: Yu Lan , Nagai Yukari
Published: March 2020

Painting materials are one of the mediums that help painters to show the effects of paintings. The use of different painting materials can help the painter to display different painting styles and artistic conception. Six hundred sixty-seven children aged 7 to 13 participated in the study. This study is mainly about the impact of the use of different painting materials on children’s painting creation. The questionnaire survey was conducted based on primary school fine arts education to study the influence of painting materials on children’s painting ability. The content of the questionnaire survey was to investigate children’s usage of different painting materials in painting works and the grasp of painting materials knowledge. This research also provided some painting materials training methods for primary school fine arts teachers to guide children to use different painting materials for painting creation based on the study results.
Daily School Physical Activity from before to after Puberty Improves Bone Mass and a Musculoskeletal Composite Risk Score for Fracture
Authors: Cronholm Felix , Lindgren Erik , Rosengren Björn E. , Dencker Magnus , Karlsson Caroline , Karlsson Magnus K.
Published: March 2020

This 7.5-year prospective controlled exercise intervention study assessed if daily school physical activity (PA), from before to after puberty, improved musculoskeletal traits. There were 63 boys and 34 girls in the intervention group (40 min PA/day), and 26 boys and 17 girls in the control group (60 min PA/week). We measured musculoskeletal traits at the start and end of the study. The overall musculoskeletal effect of PA was also estimated by a composite score (mean Z-score of the lumbar spine bone mineral content (BMC), bone area (BA), total body lean mass (TBLM), calcaneal ultrasound (speed of sound (SOS)), and muscle strength (knee flexion peak torque)). We used analyses of covariance (ANCOVA) for group comparisons. Compared to the gender-matched control group, intervention boys reached higher gains in BMC, BA, muscle strength, as well as in the composite score, and intervention girls higher gains in BMC, BA, SOS, as well as in the composite score (all p < 0.05, respectively). Our small sample study indicates that a daily school-based PA intervention program from Tanner stage 1 to 5 in both sexes is associated with greater bone mineral accrual, greater gain in bone size, and a greater gain in a musculoskeletal composite score for fractures.