bluuebunny/crossref_metadata_2025 huggingface dataset:
Study protocol: A systematic review and meta-analysis regarding the influence of coagulopathy and immune activation on new onset atrial fibrillation in patients with sepsis
Authors: Downes Michael , Welters Ingeborg D. , Johnston Brian W.
Published: September 2023

Background

New onset atrial fibrillation (NOAF) is the most common arrhythmia affecting critically ill patients with sepsis. NOAF is associated with increased intensive care unit mortality, increased hospital mortality, development of heart failure and increased risk of permanent atrial fibrillation and thromboembolic events such as stroke. The pathophysiology of NOAF has been outlined, however, a knowledge gap exists regarding the association between abnormalities in coagulation and immune biomarkers, and the risk of developing NOAF in patients with sepsis.

Methods and analysis

This protocol describes a systematic review and meta-analysis following the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols guideline (PRISMA-P) and the Meta-Analyses and Systematic Reviews of Observational Studies guideline (MOOSE). We will conduct the literature search in Medline, Scopus and Cochrane Library. We will include studies that report data in adult patients (>18 years) with sepsis that develop NOAF. We will extract data from studies that report at least one coagulation or immune biomarker. Risk of bias will be assessed by using the Newcastle Ottawa Scale (NOS) and Risk of Bias 2 tool (RoB2) for non-randomized and randomized trials respectively. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach will be utilized in assessing the quality of evidence.

Discussion

This systematic review and meta-analysis will explore the scientific literature regarding the association between coagulation and immune activation in critically ill patients with sepsis, who develop NOAF. The findings will add to the existing knowledge base of NOAF in sepsis, highlight areas of uncertainty and identify future areas of interest to guide and improve management strategies for NOAF.

Trial registration

Registration details. CRD42022385225 (PROSPERO).
The relationship between age and sex partner counts during the mpox outbreak in the UK, 2022
Authors: Brainard Julii , Smith Louise E. , Potts Henry W. W. , Rubin G. James
Published: September 2023

Background

Understanding the dynamics of an infectious disease outbreak linked to sexual activity requires valid expectations of likely counts of unique sex partners during the infectious period. Typically, age is the key demographic trait linked to expected partner count, with many transmission models removing adults from the sexually active pool abruptly at a pre-specified age threshold. Modelling the rate of decline in partner counts with age would benefit from a better description of empirical evidence.

Methods

During the 2022 mpox epidemic in the UK, we asked individuals about their partner counts in the preceding three weeks, which is about the same as usual infectious period for persons with active mpox. We used negative binomial regression (all responses) and Weibull regression (non-zero responses) to analyse the relationship between age and partner counts, adjusted for other demographic data (such as education level and occupation), sub-dividing by three types of respondent: men who have sex with men (MSM), men who have sex with women, and women who have sex with men.

Results

Most respondents had zero or one recent partner, all distributions were skewed. There was a relatively linear declining relationship between age and partner counts for heterosexual partnership groups, but a peak in partner counts and concurrency for MSMs in middle age years (age 35–54), especially for MSM who seemed to be in a highly sexually active subgroup.

Conclusion

Useful data were collected that can be used to describe sex partner counts during the British mpox epidemic and that show distinctive partner count relationships with age, dependent on partnership type.
Alterations of the bacterial ocular surface microbiome are found in both eyes of horses with unilateral ulcerative keratitis
Authors: Julien Martha E. , Shih Johnathan B. , Correa Lopes Bruna , Vallone Lucien V. , Suchodolski Jan S. , Pilla Rachel , Scott Erin M.
Published: September 2023

Next generation sequencing (NGS) studies in healthy equine eyes have shown a more diverse ocular surface microbiota compared to culture-based techniques. This study aimed to compare the bacterial ocular surface microbiota in both eyes of horses with unilateral ulcerative keratitis (UK) with controls free of ocular disease. Conjunctival swabs were obtained from both ulcerated eyes and unaffected eyes of 15 client-owned horses with unilateral UK following informed consent, as well as from one eye of 15 healthy horses. Genomic DNA was extracted from the swabs and sequenced on an Illumina platform using primers that target the V4 region of bacterial 16S rRNA. Data were analyzed using Quantitative Insights Into Molecular Ecology (QIIME2). The ocular surface of ulcerated eyes had significantly decreased species richness compared with unaffected fellow eyes (Chao1 q = 0.045, Observed ASVs p = 0.045) with no differences in evenness of species (Shannon q = 0.135). Bacterial community structure was significantly different between either eye of horses with UK and controls (unweighted UniFrac: control vs. unaffected, p = 0.03; control vs. ulcerated, p = 0.003; unaffected vs. ulcerated, p = 0.016). Relative abundance of the gram-positive taxonomic class, Bacilli, was significantly increased in ulcerated eyes compared with controls (q = 0.004). Relative abundance of the taxonomic family Staphylococcaceae was significantly increased in ulcerated and unaffected eyes compared with controls (q = 0.030). The results suggest the occurrence of dysbiosis in infected eyes and reveal alterations in beta diversity and taxa of unaffected fellow eyes. Further investigations are necessary to better understand the role of the microbiome in the pathophysiology of ocular surface disease.
Effects of aerobic exercise on body self-esteem among Chinese college students: A meta-analysis
Authors: Shu Junwen , Lu Tianci , Tao Baole , Chen Hanwen , Sui Haoran , Wang Lingzhi , Zhang Ye , Yan Jun
Published: September 2023

Objective

To investigate the effect of aerobic exercise on five dimensions of physical self-worth, exercise capacity, physical condition, physical attractiveness, and physical quality in body self-esteem of Chinese college students.

Methods

By searching PubMed, Web of Science, Cochrane Library, CNIK database, VIP database, WANFANG database platform, we searched for the subject terms or keywords "body self-esteem", "Chinese college students", "Systematic evaluation", "Aerobic exercise", "Exercise intervention", “Meta-Analysis”. The search method was a combination of subject terms and keywords and title, and the search period was from database creation to The search was conducted from database creation to May 2022. A total of 3221 articles were searched, and 9 articles were included in the study through repeated screening. Risk of bias was assessed with Cochrane and the quality of studies in the literature was assessed using Grade pro software. The outcome indicators of the included literature were analysed using review manager 5.4 software and StataMP 17.0 software.

Results

Nine papers including 1613 subjects were included. results of Meta-analysis showed that aerobic exercise was effective in improving physical self-worth (WMD = 1.46, 95% CI: 1.08–1.83, p<0.001), improving exercise capacity (WMD = 1.62, 95% CI: 1.23–2.01, p<0.001), improving physical attractiveness (WMD = 1.32, 95% CI: 0.98–1.67, p<0.001), improved physical condition (WMD = 1.32, 95% CI: 0.98–1.67, P<0.001), improved physical fitness (WMD = 1.51, 95% CI: 1.07–1.95, P<0.001). The differences were all statistically significant.

Conclusion

Aerobic exercise can effectively improve the body self-esteem of Chinese college students. In exercise, male students pursue is athletic ability and physical fitness, and female students pursue is the sense of physical self-worth and physical attractiveness. Aerobic exercise has a greater increase in body self-esteem for obese or Obese college students. Aerobics and physical dance are the most cost-effective for improving body self-esteem. Medium-intensity relative to low-intensity exercise was effective for body self-esteem intervention. A single exercise session of 90 minutes was more effective than a single 30-minute session in boosting body self-esteem, and the overall intervention duration of 16 weeks was more effective than 10 weeks.
Heat, hurricanes, and health: Effects of natural disturbances on angling effort
Authors: Midway Stephen R. , Miller Paul W.
Published: September 2023

Recreational angling is a very popular outdoor activity that is weather-dependent, although investigations of this relationship are rare. This study used weekly fishing effort (2015–2021) estimates throughout coastal Louisiana to understand how effort changed in response to weather conditions. Although we found evidence for some effect of all the weather variables, temperature reported the greatest number of monthly effects, along with an overall declining effect throughout the year. We also examined how tropical storms and hurricanes reduce fishing effort, but that effort recovers rapidly after the storm. Finally, we examined fishing effort during the first year of the pandemic (2020) compared to previous years and found some monthly increases exceeding 100% of normal effort. Understanding angler motivations remains an important part of fishery management, and in a future with changes to weather, hurricanes, and global health crises, we can now know more about how environmental factors change angling effort.
Identification of the needs of children with neurodisability and their families at different stages of development: A qualitative study protocol
Authors: Roldán-Pérez Patricia , San Miguel-Pagola Marta , Doménech-García Víctor , Bellosta-López Pablo , Buesa-Estéllez Almudena
Published: September 2023

Background

Within the field of childhood neurodisability, the tendency in the study of needs has been to categorize them based on ability (motor, verbal, cognitive). However, current perspectives such as F-words, family-centered practices, or the principles of family empowerment, lead the researcher to ask: What are these needs according to the stage of development?

Methods and analysis

A descriptive qualitative study will be carried out. Several methods will be followed to ensure the reliability and validity of the results, and the Standards for Reporting Qualitative Research and the Consolidated criteria for reporting qualitative research checklists will also be used to guide the project. Data collection is sought from three main sources: Focus groups (detection of needs), a survey to collect sociodemographic and clinical data necessary to obtain an overview of the context of the participants, and a survey to find out the level of satisfaction with this initiative.

Discussion

The results expected to be obtained after this study will respond to the main needs of families with childhood neurodisability, based on age groups and covering the whole territory of the Spanish population. Thanks to these detected needs, it will be possible to design future lines of work to improve the design of family-centered practices and increase the empowerment of families. The intention is to detect needs by stage of development, which can be categorized within the F-words framework, showing families and professionals a clear picture of the needs of this population.
Exploring the interplay of new energy vehicle enterprises, consumers, and government in the context of the "dual carbon" target: An evolutionary game and simulation analysis
Authors: Song Rui , Shi Wen , Qin Wanyi , Xue Xingjian
Published: September 2023

To achieve low-carbon and green mobility, the government needs to encourage people to buy and use new energy vehicles. This study proposes a tripartite evolutionary game model among new energy vehicle manufacturers, consumers, and government agencies. The game strategy combinations of each party and the stability conditions of the equilibrium point in the evolutionary game system are analyzed, and the validity of the conclusions is verified by simulation results. Compared with traditional studies that suggest the government should adopt the direct subsidy policy, this study shows that in the early stage of new energy vehicle development, government subsidies are still important for the rapid growth of new energy vehicle production and sales, but indirect policies can play a key role as the new energy vehicle industry matures. In addition to the price, the attractiveness of vehicle brands, the perceived utility of the products among consumers, and the coverage of charging infrastructure in cities also determine whether consumers decide to purchase and use new energy vehicles. The findings could provide useful recommendations for governments and manufacturers of new energy vehicles to meet their "dual carbon" targets.
Increasing phosphorus rate alters microbial dynamics and soil available P in a Lixisol of Zimbabwe
Authors: Tauro Tonny P. , Nezomba Hatirarami , Mtambanengwe Florence , Mapfumo Paul
Published: September 2023

Soil phosphorus (P) deficiency is a major challenge to food security in most parts of sub-Saharan Africa, including Zimbabwe, where farmers largely depend on local organic nutrient resources as fertilizer in the production of crops. Soil microorganisms can contribute to synchronous availability of soil P to plants through regulating immobilization and mineralization cycles of soil P pools but their activity may be influenced by antecedent soil P, P fertilizer application regimes and P uptake by plants. Using soils collected from plots where Crotalaria juncea (high quality), Calliandra calothyrsus (medium quality), cattle manure (variable quality), maize stover and Pinus patula sawdust (both low quality) were applied at the rate of 4 t C ha-1 with 16 kg P ha-1 at the start of every season over 16 seasons. A pot study was conducted to evaluate the influence of increasing inorganic P fertilizer rates (26 and 36 kg P ha-1) on soil microbial dynamics, soil P pools, and maize P uptake. Results indicated that nineteen (19) fungal and forty-two (42) bacterial colonies were identified over the study period. Fungi dominated bacteria on day one, with Aspergillus niger showing a 30–98% abundance that depends on organic resource quality. Overall, microbial diversity peaked activity characterized succession on day 29, which coincided with a significant (P<0.05) increase in P availability. Increasing P rate to 26 kg P ha-1 amplified the microbial diverse peak activity under medium-high quality resources while under the control the peak emerged earlier on day 15. Mucor and Bacillus had peak abundances on day 43 and 57, respectively, across treatments regardless of P rates. Treatment and P rate had a significant (P<0.01) effect on microbial P. Bacteria were more responsive to added P than fungi. Increasing P to 36 kg P ha-1 also stimulated an earlier microbial diverse peak activity under maize stover on day 15. Addition of P alone, without supplying complementary nutrients such as N, did not have a positive effect on maize P uptake. Farmers need to co-apply medium-high quality organic resources with high fertilizer P rates to increase microbial diversity, plant available P and maize growth on sandy soils (Lixisols). Our results suggest that there is a need to reconsider existing P fertilizer recommendations, currently pegged at between 26 and 30 kg P ha-1, for maize production on sandy soils as well as develop new fertilizer formulations to intensify crop production in Zimbabwe.
Spatiotemporal dynamics reveals forest rejuvenation, fragmentation, and edge effects in an Atlantic Forest hotspot, the Pernambuco Endemism Center, northeastern Brazil
Authors: Dias Thiago da Costa , Silveira Luís Fábio , Francisco Mercival Roberto
Published: September 2023

Large forested tracts are increasingly rare in the tropics, where conservation managers are often presented with the challenge of preserving biodiversity in small and isolated fragments. The Atlantic Forest is one of the world’s most important biodiversity hotspots, jeopardized by habitat loss and fragmentation. The Pernambuco Endemism Center (PEC) is the most degraded of the Atlantic Forest regions and because of the dramatic levels of deforestation, fragmentation, and ongoing species losses, studies on the distribution and configuration of the PEC’s forest cover are necessary. However, across dynamic tropical landscapes, investigating changes over time is essential because it may reveal trends in forest quality attributes. Here, we used Google Earth Engine to assess land use and land cover data from MapBiomas ranging from 1985 to 2020 to calculate current landscape metrics and to reveal for the first time the spatiotemporal dynamics of the PEC’s forests. We identified a forest cover area that ranged from 571,661 ha in 1985 to 539,877 ha in 2020, and about 90% of the fragments were smaller than 10 ha. The average fragment size was about 11 ha, and only four fragments had more than 5,000 ha. Deforestation was mostly concentrated in northern Alagoas, southern Pernambuco, and non-coastal Paraíba and Rio Grande do Norte. On average, borders represented 53.6% of the forests from 1985 to 2020, and younger forests covered 52.3% of the area in 2017, revealing a vegetation rejuvenation process 2.5 times higher than in total Atlantic Forest. In 2017, older forest cores in fragments larger than 1000 ha (i.e., higher-quality habitats) represented only 12% of the remaining forests. We recommend that the amount of forest cover alone may poorly assist conservation managers, and our results indicate that ensuring legal protection and increasing surveillance of the PEC’s few last higher-quality habitats is urgently needed.
A natural experiment study: Low-profile double plating versus single plating techniques in midshaft clavicle fractures—Study protocol
Authors: Lecoultre Yannic , van de Wall Bryan J. M. , Diwersi Nadine , Pfarr Steffen W. , Galliker Beat , Babst Reto , Link Björn-Christian , Beeres Frank J. P.
Published: September 2023

Background

Single plate osteosynthesis is commonly employed when performing surgical stabilization of midshaft clavicle fractures. In recent years, a smaller structural low-profile double plating technique has been described as a possible solution for the high removal rates associated with single plating. A previous meta-analysis has demonstrated that low-profile double plating attains the same healing rates as single plating without a higher chance of fracture-related infections. This meta-analysis, however, was based on relatively small studies. Therefore, a multicentre prospective natural experiment was designed using natural variation in treatment regimens and geographical location of the trauma as treatment allocation mechanism to compare both treatments on a larger scale. This manuscript describes its protocol.

Material & methods

Patients (≥16 years) with primary midshaft clavicle fractures that are eligible for operative treatment will be included. Treatment allocation will be determined by the geographical location of the accident and local hospital providing treatment. In two centres, single plating is the treatment of choice for these patients. In two others, low-profile double plating has become the standard treatment. For the low-profile double plating group, one superiorly positioned VariAx 2.0mm and one anterior VariAx 2.4mm or 2.7mm plate will be used. For the single plating group, the standard locally available implant will be used. A total of 336 patients will be included. The primary outcome of interest is re-intervention. Secondary outcomes include complications, operative time, length of incision, functional scores (DASH, EQ-5D-DL, VAS-Pain/Satisfaction) and cost-effectiveness.

Discussion

This study will determine whether low-profile double plating has significant clinical and cost-effective benefits over single plating techniques in midshaft clavicle fractures. The study will also give insight in the performance of a natural experiment study design for orthopedic trauma research.

Trial registration

This study has been registered on ClincialTrials.gov, identifier NCT 05579873.
Engagement in types of activities and frequency of alcohol use in a national sample of United States adolescents
Authors: Sutton Cassandra A. , Grandfield Elizabeth , Yi Richard , Fazzino Tera L.
Published: September 2023

Objective

Adolescents with fewer sources of environmental reinforcement may be at risk for alcohol use. Behavioral economic theories posit that engagement in some activities may facilitate alcohol use, whereas other activities may be incompatible with use and reduce likelihood of alcohol use. It is unclear which types of activities may facilitate or may be incompatible with alcohol use in adolescence. Using a national sample of adolescents, the current study examined differences in engagement with types of activities that may be incompatible with alcohol use, compared among adolescents who endorsed alcohol use, and adolescents who did not.

Method

Data from the 2019 Monitoring the Future (MTF) study (N = 4626) were analyzed. Potentially incompatible and facilitating activities, and alcohol-involved activities were identified from pre-existing survey measures. Confirmatory factor analysis, measurement invariance, and structural equation modeling were used to examine patterns in activity engagement among those who endorsed alcohol use and those who did not.

Results

Participants who did not endorse alcohol use reported higher engagement in activities that may be incompatible with alcohol use, including enjoyment from school and going to the mall (p < .001). Participants who endorsed alcohol use reported higher engagement in activities that may facilitate alcohol use (p < .001), such as spending time with friends and attending parties. Facilitating activities (β = 0.15, p < .001) and alcohol-involved activities (β = 0.70, p < .001) were positively associated with alcohol use frequency. Observed effect sizes were small in magnitude for all findings.

Conclusions

The findings support the premise of behavioral economic theory, suggesting some activities may serve as protective factors against alcohol use frequency while other activities may facilitate alcohol use among adolescents. National surveys may consider adding specific measure of activity engagement to identify activities that may be incompatible with alcohol use among adolescents.
Trends in all causes and cause specific mortality attributable to ambient particulate matter pollution in China from 1990 to 2019: A secondary data analysis study
Authors: Liu Yingying , Yan Mengmeng
Published: September 2023

Background

Particularly fine particulate matter (PM2.5) has become a significant public health concern in China due to its harmful effects on human health. This study aimed to examine the trends in all causes and cause specific morality burden attributable to PM2.5 pollution in China.

Methods

We extracted data on all causes and cause specific mortality data attributable to PM2.5 exposure for the period 1990–2019 in China from the Global Burden of Disease 2019. The average annual percent change (AAPC) in age-standardized mortality rates (ASMR) and years of life lost (YLLs) due to PM2.5 exposure were calculated using the Joinpoint Regression Program. Using Pearson’s correlation, we estimated association between burden trends, urban green space area, and higher education proportions.

Results

During the period 1990–1999, there were increases in mortality rates for All causes (1.6%, 95% CI: 1.5% to 1.8%), Diabetes mellitus (5.2%, 95% CI: 4.9% to 5.5%), Encephalitis (3.1%, 95% CI: 2.6% to 3.5%), Ischemic heart disease (3.3%, 95% CI: 3% to 3.6%), and Tracheal, bronchus and lung cancer (5%, 95% CI: 4.7% to 5.2%). In the period 2010–2019, Diabetes mellitus still showed an increase in mortality rates, but at a lower rate with an AAPC of 1.2% (95% CI: 1% to 1.4%). Tracheal bronchus and lung cancer showed a smaller increase in this period, with an AAPC of 0.5% (95% CI: 0.3% to 0.6%). In terms of YLLs, the trends appear to be similar.

Conclusion

Our findings highlight increasing trends in disease burden attributable to PM2.5 in China, particularly for diabetes mellitus, tracheal, bronchus, and lung cancer.
Antimicrobial, antioxidant, anti-inflammatory, and cytotoxic activities of Cordyceps militaris spent substrate
Authors: Zhang Danyu , Tang Qingjiu , He Xianzhe , Wang Yipeng , Zhu Guangyong , Yu Ling
Published: September 2023

Cordyceps militaris is a medicinal mushroom and has been extensively used as a traditional medicine in East Asia. After the chrysalis seeds are matured and harvested, the spent substrate of C. militaris still contains active ingredients but is usually discarded as waste. This study aimed to determine the antioxidant and anti-inflammatory activities of C. militaris spent substrate extract and its inhibitory activity on the Malassezia commensal yeasts that can cause dandruff and seborrheic dermatitis. Active substances in the spent substrate of C. militaris were extracted using a hot water extraction method and were used for the determination of antioxidant activity by measuring their ability to scavenge 2,2-diphenyl-1-picrylhydrazyl (DPPH), hydroxyl radicals, hydrogen peroxide, and superoxide anions. The ability to inhibit Malassezia was analyzed using the broth microdilution method, and the reparative effect on oxidative damage in HaCaT cells was measured using in vitro cell analysis. Respiratory burst evaluation was used to determine the anti-inflammatory capacity of extracts. Analysis of the Malassezia-inhibiting activity of the extracts showed that the minimum inhibitory concentration was 6.25 mg/mL. The half maximal inhibitory concentration (IC50) values of DPPH, O2-, H2O2 and OH- were 3.845 mg/mL, 2.673 mg/mL, 0.037 mg/mL and 0.046 mg/mL, respectively. In the concentration range of 2 to 50%, the extract was non-toxic to cells and was able to protect HaCaT cells from H2O2 damage. When the volume fraction of the extract was 20.96%, its anti-inflammatory ability reached 50%. These results demonstrated that the extract may be a safe and efficacious source for pharmaceutical or cosmetic applications, with Malassezia-inhibiting, antioxidant and anti-inflammatory activities.
Global algebraic Poincaré–Bendixson annulus for the Rayleigh equation
Authors: Grin Alexander , Schneider Klaus
Published: September 2023

We consider the Rayleigh equation

x
¨

+
λ
(

x
˙

2

/

3
−
1
)

x
˙

+
x
=
0
depending on the real parameter
λ
and construct a Poincaré–Bendixson annulus

A

λ

in the phase plane containing the unique limit cycle

Γ
λ

of the Rayleigh equation for all
λ
>
0
. The novelty of this annulus consists in the fact that its boundaries are algebraic curves depending on
λ
. The polynomial defining the interior boundary represents a special Dulac–Cherkas function for the Rayleigh equation which immediately implies that the Rayleigh equation has at most one limit cycle. The outer boundary is the diffeomorphic image of the corresponding boundary for the van der Pol equation. Additionally we present some equations which are linearly topologically equivalent to the Rayleigh equation and provide also for these equations global algebraic Poincaré–Bendixson annuli.
Ground state solution for fractional problem with critical combined nonlinearities
Authors: Xu Er-Wei , Sun Hong-Rui
Published: September 2023

This paper is concerned with the following nonlocal problem with combined critical nonlinearities

(
−
Δ

)

s

u
=
−
α

|

u

|

q
−
2

u
+
β

u

+
γ

|

u

|

2

s

∗

−
2

u

in
 
Ω
,

u
=
0

in
 

R

N

∖
Ω
,
where
s
∈
(
0
,
1
)
,
N
>
2
s
,
Ω
⊂

R

N

is a bounded

C

1
,
1

domain with Lipschitz boundary,
α
is a positive parameter,
q
∈
(
1
,
2
)
,
β
and
γ
are positive constants, and

2

s

∗

=
2
N

/

(
N
−
2
s
)
is the fractional critical exponent. For
γ
>
0
, if
N
⩾
4
s
and
0
<
β
<

λ

1
,
s

, or
N
>
2
s
and
β
⩾

λ

1
,
s

, we show that the problem possesses a ground state solution when
α
is sufficiently small.
Addendum to ``Ulam–Hyers stability and exponentially dichotomic equations in Banach spaces'' [Electron. J. Qual. Theory Differ. Equ. 2023, No. 8, 1–10]
Authors: Buică Adriana
Published: September 2023

We add relevant references about which we learned after the completion of the initial work. We mainly show how the concept of exponential trichotomy can successfully replace the one of exponential dichotomy in some results from the paper in the title.
Lecture de l'entretien de Véronique Girod-Roux
Authors: Lambotte François , Lépine Valérie
Published: September 2023

Dans un contexte social post #MeToo et de mouvement de libération de la parole des femmes sur les agressions qu’elles subissent dans l’espace public et professionnel, l’actualité médiatique met régulièrement en avant des initiatives pour dénoncer les discriminations et aller vers plus d’égalité. Pourtant en France, à l’échelle d’une association de communication locale, les enjeux liés au genre demeurent tabous et sont difficilement mis à l’agenda des priorités. Ce constat est dressé par une communicante expérimentée qui a animé pendant dix ans une association professionnelle de la communication lors d’un entretien accordé le 14 avril 2021 à Valérie Lépine, enseignante-chercheuse en SIC, pour la revue Communication & professionnalisation.
Strategy for Reducing Regional Economic Disparities in Gerbangkertosusila: A Cluster Regional Approach Based on Leading Sectors
Authors: Fransiska Belia , Setiawan Edi
Published: September 2023

The existence of regional clusters has a favourable influence on the prosperity and development of a region. Regional clusters have the potential to create a conducive environment that encourages businesses to develop. In addition, they promote regional growth and development; therefore, those regions provide trickle-down effects to the surrounding. Gerbangkertosusila (GKS), as a metropolitan area, has an important role in the economic development of East Java Province because had several economic activities. However, in fact, the economic development in the GKS area is uneven and results in inequality. Furthermore, the changes in the aspect of regional economic development had also not balanced with the formulation of appropriate policies. Therefore, this paper aims to propose strategies to reduce the regional economic disparities in the GKS area. The analysis will use Williamson Index to determine regional inequality and LQ (Location Quotient) to determine the performance of each sector. From the analysis results, we offer some strategies based on the leading sectors and regional competitiveness there that was: 1. Strategies based on natural resource management and local economic development in cluster A (Lamongan and Bangkalan Districts) that have advantages in resource endowment; 2. Strategies to strengthen the productive business environment and environmentally friendly industries that are interrelated in cluster B (Sidoarjo, Gresik, and Mojokerto districts); 3. Strategy based on optimization of urban roles and functions supported by the development of human resources and the development of the creative economy in cluster C (Mojokerto City and Surabaya City).
Transformation in substation automation: Cyber-Resilient Digital Substations (CyReDS) in power grids
Authors: Rösch Dennis , Bauer Thomas , Kummerow André , Kühne Marcel , Nicolai Steffen , Bretschneider Peter
Published: September 2023

The digitalization of substations leads to a high degree of automation, which is referred to as Digital Substations with the use of the IEC 61850. An increase in cybersecurity is necessary, and technically enabled by detection and incident response systems – security-by-design is currently often secondary. The next transformation step of substations is introduced and outlined in this paper as a cyber-resilient digital substation. Based on a state-of-the-art description, this paper presents a definition of cyber resilience for digital substations as a basis for the introduced cyber resilience monitor. The monitor acts as a central instance for recording, assessing and responding to security threats and incidents. Furthermore, the requirements for the system structure of the cyber-resilient digital substation are shown and underpinned with current research approaches.
A new hybrid risk assessment process for cyber security design of smart grids using fuzzy analytic hierarchy processes
Authors: Canbolat Sine , Elbez Ghada , Hagenmeyer Veit
Published: September 2023

IT vulnerabilities, cyber threats, and resulting risks significantly impact the stability of current and future power grids. The results of a Risk Assessment process contribute to a better understanding of the causes and nature of the associated risks. The risks assessed by experts are available in both numerical and linguistic representations – this makes it beneficial to include a combination of linguistic and numerical analyses. In this paper, we propose a new Hybrid Risk Assessment method based on fuzzy logic, leading to more precise results. The presented approach specifies the variables and membership functions of fuzzy logic with reference to Smart Grids. For this propose, a case study with five risk events in a small-scale Smart Grid is carried out as an example. The results can then support decision-makers in ensuring grid stability.
Loss of ACOX1 in clear cell renal cell carcinoma and its correlation with clinical features
Authors: Mo Yingxi , Zhao Jun , Zhao Ran , Huang Yiying , Liang Ziyuan , Zhou Xiaoying , Chu Jiemei , Pan Xinli , Duan Siyu , Chen Shiman , Mo Liufang , Huang Bizhou , Huang Zhaozhang , Wei Jiale , Zheng Qian , Luo Wenqi
Published: September 2023

Clear cell renal cell carcinoma (ccRCC) is a major pathological type of kidney cancer with a poor prognosis due to a lack of biomarkers for early diagnosis and prognosis prediction of ccRCC. In this study, we investigated the aberrant expression of Acyl-coenzyme A oxidase 1 (ACOX1) in ccRCC and evaluated its potential in diagnosis and prognosis. ACOX1 is the first rate-limiting enzyme in the peroxidation β-oxidation pathway and is involved in the regulation of fatty acid oxidative catabolism. The mRNA and protein levels of ACOX1 were significantly downregulated in ccRCC, and its downregulation was closely associated with the tumor-node-metastasis stage of patients. The ROC curves showed that ACOX1 possesses a high diagnostic value for ccRCC. The OS analysis suggested that lower expression of ACOX1 was closely related to the worse outcome of patients. In addition, gene set enrichment analysis suggested that expression of ACOX1 was positively correlated with CDH1, CDH2, CDKL2, and EPCAM, while negatively correlated with MMP9 and VIM, which strongly indicated that ACOX1 may inhibit the invasion and migration of ccRCC by reversing epithelial-mesenchymal transition. Furthermore, we screened out that miR-16-5p is upregulated at the mRNA transcript level in ccRCC and negatively correlated with ACOX1. In conclusion, our results showed that ACOX1 is abnormally low expressed in ccRCC, suggesting that it could serve as a diagnostic and prognostic biomarker for ccRCC. Overexpression of miR-16-5p may be responsible for the inactivation of ACOX1.
Pineapple fruit residue-based nanofibre composites: Preparation and characterizations
Authors: Jayaprakash Sajithkumar K. , Chellappan Suchith , Prasannan Sruthi A. , Padil Vinod V. T.
Published: September 2023

Natural fibre composites are widespread for being eco-friendly and having unique properties. This study prepared nanocomposites by water evaporation using cellulose nanofibres (CNFs) as fillers and natural rubber (NR) latex as the matrix. Here, CNFs were extracted from the “pineapple fruit residue,” a waste material in juice industries. These fibre-reinforced nanocomposites were prepared under three different weight/volume percentages (5%, 10%, and 15%) and analysed for their mechanical and thermal properties. Furthermore, the morphology and distribution of CNFs in the NR matrix were examined by scanning electron microscopy and Fourier transform-infrared (FT-IR) analysis. The study found that CNFs were randomly oriented and evenly distributed in the nanocomposite. CNFs were detected by FT-IR spectroscopy in the NR matrix, as indicated by absorption peaks at 1,033 and 1,057 cm−1. Thermogravimetric analysis reveals increased thermal stability with more CNFs. Tensile strength and elastic modulus also increase. Pineapple fruit residue-based CNFs enhance mechanical and thermal properties of NR composites and can be considered an ideal natural reinforcing material.
Numerical analysis of various shapes of lozenge pin-fins in microchannel heat sink
Authors: Haque Injamamul , Alam Tabish , Yadav Jagmohan , Gupta Naveen Kumar , Haque Siddiqui Md Irfanul , Siddiqui Tauseef Uddin , Ali Naushad , Srivastava Shivam , Yadav Anil Singh , Sharma Abhishek , Khargotra Rohit , Thakur Amit Kumar
Published: September 2023

Higher density heat flux is the major cause of damage to the electronic component; therefore, cooling such components are of the utmost importance to operate in a safe zone and to increase their life. For this purpose, Microchannel heat sinks (MHSs) are among the most practical methods for dissipating unwanted heat. In this regard, the novel lozenge-shaped pin-fins in the flow passage of the microchannel heat sink (MHS) have been designed and proposed to achieve higher cooling performance. Aspect ratios (λ = 0.30, 0.39, 0.52, 0.69, 1.00) of several lozenge-shaped pin-fins have been used into the design of MHS to investigate their impact on heat transmission and fluid flow characteristics. A three-dimensional model of MHS with a lozenge-shaped has been generated and simulated numerically in the following range of Reynolds numbers, starting from 100 to 900. Heat transmission and flow characteristics have been presented and discussed in detail. It has been found that introducing lozenge-shaped pin-fins in MHS has greatly improved cooling performance. The highest improvement in Nusselt number has been observed when aspect ratio (λ) of lozenge-shaped pin-fins was 1.00. The Nusselt number have been varied in the following ranges of 6.96–12.34, 6.97–12.72, 7.01–13.62, 7.09–14.43, and 7.12–15.26 at λ = 0.30, λ = 0.39, λ = 0.52, λ = 0.69, and λ = 1.0, respectively. In addition, a study of the thermohydraulic performance of the proposed lozenge-shaped pin-fins in the MHS found that this design is an effective means of lowering operating temperature.
A comparative analysis of two cases of language death and maintenance in post-Islam Egypt and Great Khorāsān: reasons and motives
Authors: Dehghan Farzaneh , Dehghan Masoumeh , Farkhondehzadeh Mahboobeh
Published: September 2023

This paper compares two areas of Egypt and Khorāsān in post-Islamic era regarding the loss and maintenance of their mother tongues. While in Egypt, Coptic was gradually removed from both formal and colloquial usages, in Khorāsān, Persian (Farsi or Parsi Dari), though was out of official and governmental services for more than two centuries, was able to finally maintain its status. The most important reason found behind this difference can be attributed to the independence seeking movements in Khorāsān (e.g. Sho’ūbieh), leading to the establishment of the first post-Islamic independent Iranian governments who supported the revival of Iranian culture and the maintenance of Persian language. Secondly, the migration of Arab tribes and the Arabization of the conquered societies were more successful in Egypt compared to Eastern Iran, which changed the demographic composition of Egypt. Moreover, the role of Persian-speaking epic poets, the social class of dihgāns in Iranian society and the fact that Coptic was not as old a language as Persian are other important reasons. It is argued that language maintenance can happen better in cases where top–down governmental and institutional support exists.
Stem cell therapy in sports medicine: current applications, challenges and future perspectives
Authors: Palermi Stefano , Gnasso Rossana , Belviso Immacolata , Iommazzo Irene , Vecchiato Marco , Marchini Andrea , Corsini Alessandro , Vittadini Filippo , Demeco Andrea , De Luca Mariarosaria , Tarantino Domiziano , Romano Veronica , Sacco Annamaria , Sirico Felice
Published: September 2023

Stem cells have demonstrated significant potential for tissue repair and regeneration, making them a promising therapeutic avenue in sports medicine. This review aims to provide a comprehensive overview of the current state of research on the application of stem cells in sports medicine. We will discuss the types of stem cells used, their mechanisms of action, and the clinical outcomes of stem cell therapy in different sports-related injuries. Furthermore, we will delve into the challenges and ethical considerations associated with stem cell therapy, as well as future directions and potential applications of stem cells in sports medicine.
The Systematic Unity of Reason and Empirical Truth in Kant’s

Critique of Pure Reason
Authors: Spagnesi Lorenzo
Published: September 2023

This paper attempts a reconstruction of reason’s contribution to empirical truth in connection with Kant’s definition of truth as the agreement of cognition with its object. I argue that Kant’s treatment of truth in the Transcendental Analytic is completed in the Appendix to the Transcendental Dialectic with an often neglected but compelling argument (what I shall call the Variety Argument). This argument postulates such a variety among appearances as to undermine any attempt to formulate empirical truths. Crucially, I argue that this variety does not depict an extreme scenario, but rather our own epistemic situation in the absence of reason. Reason completes Kant’s theory of truth by allowing the understanding (i) to form empirical concepts and (ii) to approximate empirical truth.
Opening graves and turtles. The pond turtle (Emys orbicularis L.) from the cemetery of the Wielbark Culture in Czarnówko and the question of post-funeral interferences in the past
Authors: Skóra Kalina
Published: September 2023

In 2010, the remains of a pond turtle were discovered at the bottom of a secondary pit (“robbery” trench) in one of the graves (feature 963) in the Wielbark Culture cemetery at Czarnówko (PL). This paper attempts to characterise the find from Czarnówko in the context of two important questions: the opening of graves and the presence of turtle remains in the grave against the background of similar finds from the Central and East European Barbaricum. The problem of post-burial manipulation affects about 90 % of the graves in the cemetery at Czarnówko. The situation from grave 963 finds analogies in the burial grounds of the Masłomęcz Group, the Chernyakhiv culture and the Sarmatian and Longobard sites. The problem of the presence of these reptiles in the graves is related as it turns out to the phenomenon of grave opening, a phenomenon of great territorial and chronological extent observed in the areas where inhumation was practised during the Roman Period and the Migration Period.
Cova Dones: a major Palaeolithic cave art site in eastern Iberia
Authors: Ruiz-Redondo Aitor , Barciela Virginia , Martorell Ximo
Published: September 2023

This article presents details of the recent discovery of Palaeolithic cave art in Cova Dones, Valencia. The preliminary results reveal a rich graphic assemblage with features that are unusual for Mediterranean Upper Palaeolithic art and were previously unknown for the Pleistocene in the eastern Iberian coast.
Time-Saving Versus Time-Efficient Training Terminology, Methods, and Prescription
Authors: Bonder Ian J. , Waller Michael , Shim Andrew L. , Tangeman Marc A.
Published: September 2023

A common obstacle to achieving recommended physical activity and desired training goals is time. This is true for recreationally trained adults and athletes, particularly at the collegiate level, where greater restrictions on practice time and training are in place. One possible solution is to implement time-saving and time-efficient training routines and methods that may limit the amount of time needed to attain desired physiological adaptations—by decreasing the time needed to train and/or by increasing the frequency with which brief workouts are completed throughout the week (e.g., “microdosing”). To provide the most optimal training stimulus, the correct method must be used. Unfortunately, numerous terms describe routines and methods discussed in the current body of available literature, many of which may seem similar and lead to confusion. The purpose of this article is to outline the similarities and differences of the numerous time-saving and time-efficient training routines and methods. Ultimately, this article synthesizes the current research into practical recommendations as programming options for strength and conditioning coaches and personal trainers. The information provided may also serve as a foundation for future research opportunities in time-saving and time-efficient training.
A Novel Needle Mouse Model of Vascular Cognitive Impairment and Dementia
Authors: Weng Zhongfang , Cao Catherine , Stepicheva Nadezda A. , Chen Fenghua , Foley Lesley M. , Cao Sarah , Bhuiyan Mohammad Iqbal H. , Wang Qingde , Wang Yuan , Hitchens T. Kevin , Sun Dandan , Cao Guodong
Published: September 2023

Bilateral common carotid artery (CCA) stenosis (BCAS) is a useful model to mimic vascular cognitive impairment and dementia (VCID). However, current BCAS models have the disadvantages of high cost and incompatibility with magnetic resonance imaging (MRI) scanning because of metal implantation. We have established a new low-cost VCID model that better mimics human VCID and is compatible with live-animal MRI. The right and the left CCAs were temporarily ligated to 32- and 34-gauge needles with three ligations, respectively. After needle removal, CCA blood flow, cerebral blood flow, white matter injury (WMI) and cognitive function were measured. In male mice, needle removal led to ∼49.8% and ∼28.2% blood flow recovery in the right and left CCA, respectively. This model caused persistent and long-term cerebral hypoperfusion in both hemispheres (more severe in the left hemisphere), and WMI and cognitive dysfunction in ∼90% of mice, which is more reliable compared with other models. Importantly, these pathologic changes and cognitive impairments lasted for up to 24 weeks after surgery. The survival rate over 24 weeks was 81.6%. Female mice showed similar cognitive dysfunction, but a higher survival rate (91.6%) and relatively milder white matter injury. A novel, low-cost VCID model compatible with live-animal MRI with long-term outcomes was established.

SIGNIFICANCE STATEMENTBilateral common carotid artery (CCA) stenosis (BCAS) is an animal model mimicking carotid artery stenosis to study vascular cognitive impairment and dementia (VCID). However, current BCAS models have the disadvantages of high cost and incompatibility with magnetic resonance imaging (MRI) scanning due to metal implantation. We established a new asymmetric BCAS model by ligating the CCA to various needle gauges followed by an immediate needle removal. Needle removal led to moderate stenosis in the right CCA and severe stenosis in the left CCA. This needle model replicates the hallmarks of VCID well in ∼90% of mice, which is more reliable compared with other models, has ultra-low cost, and is compatible with MRI scanning in live animals. It will provide a new valuable tool and offer new insights for VCID research.