bluuebunny/crossref_metadata_2025 huggingface dataset:
The Opioid Analgesic Reduction Study (OARS): A Comparison of Opioid vs. Non-Opioid Combination Analgesics for Management of Post-Surgical Pain Study Protocol for a Double-Blind Randomized Multi-Center Clinical Trial
Authors: Feldman Cecile A. , Fredericks-Younger Janine , Lu Shou-En , Desjardins Paul J. , Malmstrom Hans , Miloro Michael , Warburton Gary , Ward Brent , Ziccardi Vincent , Fine Daniel
Published: December 2021

Background: Everyday people die unnecessarily from opioid overdose-related addiction. Dentists are among the leading prescribers of opioid analgesics. Opioid seeking behaviors have been linked to receipt of initial opioid prescriptions following the common dental procedure of third molar extraction. With each opioid prescription a patient’s risk for opioid misuse or abuse increases. With an estimated 56 million tablets of 5 mg hydrocodone annually prescribed after third molar extractions in the United States, 3.5 million young adults may be unnecessarily exposed to opioids by dentists who are inadvertently increasing their patient’s risk for addiction.Methods: A double blind, stratified randomized, multi-center clinical trial has been designed to evaluate whether a combination of over-the-counter non-opioid containing analgesics is not inferior to the most prescribed opioid analgesic. The impacted 3rd molar extraction model is being used due to the predictable severity of the post-operative pain and generalizability of results. Within each site/clinic and gender type (male/female), patients are randomized to receive either OPIOID (hydrocodone/acetaminophen 5/300 mg) or NON-OPIOID (ibuprofen/acetaminophen 400/500 mg). Outcome data include pain levels, adverse events, overall patient satisfaction, ability to sleep, and ability to perform daily functions. To develop clinical guidelines and a clinical decision making tool, pain management, extraction difficulty and number of tablets taken is being collected enabling an experimental decision making tool to be developed. Discussion: The proposed methods address the short comings of other analgesic studies. Although prior studies have tested short-term effects of single doses of pain medications, patients and their dentists are interested in managing pain for the entire post-operative period, not just the first 12 hours. After surgery, patients expect to be able to perform normal daily functions without feeling nauseous or dizzy and they desire a restful sleep at night. Parents of young people are concerned with the risks of opioid use and misuse, either related to treatments received or to subsequent use of leftover pills. Upon successful completion of this clinical trial, dentists, patients, and their families will be better able to make informed decisions regarding post-operative pain management.Trial registration: ClinicalTrials.gov NCT04452344. Registered on June 20, 2020
Suğla Gölü Çevresi Prehistorik Dönem Yüzey Araştırması 2020 Yılı Çalışmaları
Authors: GÜNDÜZ Ramazan
Published: December 2021

Bu çalışma Suğla Gölü Çevresi Prehistorik Dönem Yüzey Araştırması kapsamında
2020 yılında çalışmaları yapılan alanların ve bu alanlarda ele geçen arkeolojik eserlerin bir
ön değerlendirmesi niteliğindedir. 2020 yılı çalışmalarının öncelikli amacı bölgenin
Prehistorik Dönemdeki durumunun anlaşılmasına katkı sağlamaktır. İlk aşamada bölgedeki
yerleşmelerin tanımlanması, arkeolojik envanterinin çıkarılması ve güncel durumlarının
tespit edilmesi planlanmıştır. Çalışmalardan elde edilen sonuçlar bölgenin Prehistorik
Dönemleri hakkında yeni bilgiler edinmemize olanak sağlamıştır. Bu güne kadar Suğla Gölü
çevresinde Neolitik ve/veya Kalkolitik Dönemde yalnız Suberde ve Gökhöyük Bağları
Höyükte yerleşim olduğu biliniyorken 2020 yılı çalışmaları sonunda bölgede 6 yeni
yerleşmede daha Geç Neolitik ve/veya Kalkolitik Dönem kültür kalıntıları tespit edilmiştir.
Söz konusu yerleşmelerin en erken MÖ 7. binin sonu ve/veya 6.binyılın başına
tarihlenebileceği öngörülmüştür. Bu yerleşmelerde tespit edilen buluntuların ortak özellikler
göstermesinden bölge içerisinde homojen bir kültürün var olduğu anlaşılmıştır.
Ratio of spleen height to left kidney height in children and adolescents according to intravital imaging data
Authors: Chemezov Sergey V. , Lozinskiy Andrey S.
Published: December 2021

Objective: to establish age and gender patterns of changes in the ratio of spleen height to left kidney height in children and adolescents of Orenburg region according to the data of intravital imaging. Materials and methods. Abdominal CT scans of 75 children without visible pathology were examined. The surveyed were divided into 4 age groups: early childhood, first childhood, second childhood, adolescence. The study was performed on 16-slice computed tomographs with the determination of the height of the spleen and the left kidney and calculation of the ratio of these parameters. The obtained data were subjected to variation-statistical processing with the determination of the mean value (M), standard error (m) and the reliability of differences according to the Student's t-test. Results. It was found that the indicator of the height of the spleen among all the examined changed from 7.1±0.3 cm in the 1st group to 10.2±0.3 cm in the 4th group (p=0.001). The height of the left kidney in the 1st group was 7.6±0.1 cm and increased by the 4th group to 10.2±0.1 cm (p=0.001). The smallest value of the ratio of the height of the spleen to the height of the left kidney among girls and boys was found in children of early childhood and was 0.90±0.10 and 0.93±0.04. The maximum value of the indicator among girls was 1.05±0.08 in children of the second childhood, and among boys, 1.05±0.07 in children of first childhood. Conclusion. There are no significant differences between the indicators of the ratio of spleen height to left kidney height, depending on age, and there are no gender differences within the group.
O trabalho de visibilização dos indígenas nos estudos sobre Minas Gerais
Authors: Uchoas Guimarães Gustavo
Published: December 2021

O estudo da História Indígena em Minas, hoje, tem vigor dentro da academia, podendo destacar, por exemplo, os estudos de Maria Leônia Chaves de Resende. Mas, há ainda grande lacuna em relação ao sul de Minas, que, no período colonial, foi dos principais pontos de circulação entre Rio/São Paulo e a região das minas de ouro, o que afetou as dinâmicas dos povos indígenas que viviam ou passavam ali. Este estudo propõe uma breve recapitulação do que vem sendo estudado sobre a História Indígena sul-mineira, com foco na Serra da Mantiqueira e no rio Verde, a partir do município de Virgínia, mostrando o que foi feito até agora e o que se pretende fazer para aprofundar as pesquisas e contribuir para o resgate e valorização dos elementos indígenas na sociedade sul-mineira.
História e Grafismos
Authors: Alves de Mendonça Vinícius
Published: December 2021

Este trabalho possui o objetivo de realizar um estudo historiográfico sobre os usos da pintura corporal entre os indígenas Jiripankó, habitantes no alto sertão do estado de Alagoas. Assim, historicizamos a presença do grafismo corporal ao longo da formação do grupo e sua contribuição enquanto representação da memória e identidade da etnia; o descrevendo, portanto, enquanto parte importante da história dos referidos indígenas. Metodologicamente, realizamos estudos a partir de fontes documentais referentes ao processo de reconhecimento da etnia, essas sendo seguidas pela pesquisa empírica caracterizada pela produção de fotografias, anotações em diários de campo e realização de entrevistas, proporcionando uma análise da história e memória envoltas na pintura corporal daquela sociedade.
ALIMENTAÇÃO ESCOLAR: EM BUSCA DA QUALIDADE
Authors: Pinheiro Liana Galvão Bacurau , Cardonha Ângela Maria Soares , Bezerra Ingrid Wilza Leal , Rocha Neide Maria Ferreira da , Holland Nély , Silva Michelle Cristine Medeiros da , Alves Jussara Cristina , Silva Gidyenne Christine Bandeira da , Damasceno Karla Suzanne Florentino da Silva Chaves
Published: December 2021

O Projeto de Extensão Alimentação escolar: em busca da qualidade, realizado em uma parceria entre a Secretaria de Estado da Educação e da Cultura (SEEC/RN) e a Universidade Federal do Rio Grande do Norte (UFRN), executado pelo Departamento de Nutrição (DNUT), por meio da Fundação de Pesquisa do Rio Grande do Norte (FUNPEC), foi resultado de uma licitação pública. O projeto teve a vigência de 04 (quatro) anos (2011 a 2015) e o objetivo principal de contribuir para o fortalecimento das ações relacionadas à execução do Programa Nacional de Alimentação Escolar (PNAE) nas escolas da rede pública estadual de ensino do RN. O desenvolvimento das ações propostas nesse projeto visou atender a necessidade de realizar ações de planejamento, orientação e monitoramento das atividades na execução do PNAE. Com isso, fortalece-se a segurança alimentar e nutricional da refeição oferecida aos usuários do programa. Dessa forma, contribuindo no atendimento às recomendações da Portaria Interministerial nº 1010, que institui as normas para a promoção da alimentação saudável nas escolas em concordância com a legislação (Resolução nº 26/2013 FNDE e a Lei 11.947 de 16 de junho de 2009) e ao Marco de Referência em Educação Alimentar e Nutricional (2012). A consecução das metas propostas contribuiu para o melhoramento e fortalecimento do PNAE nas escolas da rede estadual de ensino do RN.
INTERAÇÃO UNIVERSIDADE-ESCOLA: USO DE JOGOS DIDÁTICOS PARA CONHECER E PREVENIR O Aedes aegypti
Authors: Santos Déborah Cristina Miranda dos , Silva Anayza Priscila Lourenço da , Costa Ivaneide Alves Soares da , Andrade Souza Giulianna Paiva Viana de
Published: December 2021

Com o objetivo de sensibilizar e alertar a comunidade escolar acerca da prevenção e malefícios causados pelo Aedes aegypti, agente transmissor do Zyka vírus, Dengue e Chikungunya, realizou-se uma ação conjunta com Secretaria de Educação de Natal, Pró Reitoria de Extensão da UFRN, Universidade Federal Rural do Semiárido (UFERSA) e o Instituto Federal de Educação Tecnológica (IFRN), na Escola Estadual Peregrino Júnior, no município de Natal. Assim, uma sequência de jogos educativos retirados do site do Ministério da Saúde foi aplicada. Os jogos utilizados foram “Verdade ou mito”, “Caça-Palavras”, “Onde está o Aedes?” e o “Jogo dos 7 erros” executados exatamente nessa sequência. A ação atingiu um público estimado de quase 260 alunos, contemplando nove turmas incluindo nível fundamental e médio.  Percebeu-se grande interesse dos participantes em conhecer a biologia do Aedes aegypti, doenças que esse vetor pode transmitir, e desenvolver ações de combate ao mosquito. Essa ação se mostrou relevante por contribuir para o empoderamento da população quanto à problemática atual do Aedes tornando-os ativos na prevenção dessas doenças
ATIVIDADE EXPERIMENTAL COMO ESTRATÉGIA DE ENSINO PARA SISTEMATIZAÇÃO DO CONTEÚDO DE CÁLCULOS QUÌMICOS: UM RELATO DO PIBID-QUÍMICA DA UFRN
Authors: De Souza Fernanda Justino , Da Silva Jonathan Atkinson Freire , Mazze Fernanda Marur
Published: December 2021

A atividade experimental é uma importante ferramenta para auxiliar no processo de ensino-aprendizagem. Seu objetivo é fazer com que a teoria se adapte à realidade, havendo uma correlação entre os dois tipos de atividades, ou seja, teórica e prática. O artigo em questão aborda uma sequência didática sobre cálculos químicos envolvendo aulas: expositivas-dialogadas, experimentais e de verificação de aprendizagem. A abordagem realizada proporcionou aos discentes uma aproximação entre conteúdos teóricos e procedimentais.
A INTERIORIZAÇÃO DA SÍFILIS
Authors: César Vieira de Araújo Túlio , Fernandes Tritany Elaine , Barros de Souza Marize
Published: December 2021

Objetivo: Descrever o perfil epidemiológico dos casos de sífilis em um município do Rio Grande do Norte. Métodos: Estudo descritivo documental com os casos notificados entre 2013 e 2017. Resultados: Os achados foram analisados de acordo com quatro grupos, sendo eles; Completude e consistência: 59,6% das notificações estavam com o item “bairro” em branco, em 21% a variável “gestante” estava inconsistente; Sífilis adquirida, gestacional e congênita: 91% das notificações foram oriundas das Unidades Básicas de Saúde, 59,6% ocorreram na zona urbana; Sífilis adquirida e gestacional: idade entre 13 e 82 anos, 27,4% dos casos tinha o item escolaridade como “ignorado”; Sífilis gestacional: 40% dos diagnósticos ocorreram no 1º trimestre, 13,3% dos parceiros foram tratados. Conclusão: A incidência apresentou valores crescentes nos anos de estudo seguindo o panorama nacional.
New Insights into the Biosensing of Parkinson's Disease Biomarkers:
A Concise Review
Authors: Hosseini Elaheh Sadat , Mohammadi Soheila , Khodarahmi Reza , Fouani Mohamad Hassan , Tavallaei Omid , Jaberi Khojaste Rahimi , Shabaninejad Zahra , Janfaza Sajjad , Yazdian-Robati Rezvan , Sajadimajd Soraya
Published: December 2021

Background:

Parkinson’s disease (PD) is a long-term, degenerative, and neurological
disease in which a person loses control of certain body functions. The formulation
of novel effective therapeutics for PD as a neurodegenerative disease requires accurate
and efficient diagnosis at the early stages.

Objective:

Analyzing data gathered by measurable signals converted from biological reactions
allows for qualitative and quantitative evaluations. Among various approaches reported
so far, biosensors are powerful analytical tools that have been used in detecting the
biomarkers of PD.

Methods:

Biosensor’s biological recognition components include antibodies, receptors,
microorganisms, nucleic acids, enzymes, cells and tissues, and biomimetic structures.
This review introduces electrochemical, optical, and optochemical detection of PD biomarkers
based on recent advances in nanotechnology and material science, which resulted
in the development of high-performance biosensors in this field.

Results:

PD biomarkers such as α-synuclein protein, dopamine (DA), urate, ascorbic acid,
miRNAs, and their biological roles are summarized. Additionally, the advantages and disadvantages
of the usual standard methods are reviewed. We compared electrochemical,
optical, and optochemical biosensors' properties and novel strategies for higher sensitivity
and selectivity.

Conclusion:

The development of novel biosensors is required for the early diagnosis of
PD as sensitive, rapid, reliable, and cost-effective systems.
Transfer Learning of the ResNet-18 and DenseNet-121 Model Used to Diagnose
Intracranial Hemorrhage in CT Scanning
Authors: Zhou Qi , Zhu Wenjie , Li Fuchen , Yuan Mingqing , Zheng Linfeng , Liu Xu
Published: December 2021

Objective:

To verify the ability of the deep learning model in identifying five subtypes and normal images in noncontrast enhancement CT of intracranial hemorrhage.

Method:

A total of 351 patients (39 patients in the normal group, 312 patients in the intracranial hemorrhage group) performed with intracranial hemorrhage noncontrast enhanced CT were selected, with 2768 images in total (514 images for the normal group, 398 images for the epidural hemorrhage group, 501 images for the subdural hemorrhage group, 497 images for the intraventricular hemorrhage group, 415 images for the cerebral parenchymal hemorrhage group, and 443 images for the subarachnoid hemorrhage group). Based on the diagnostic reports of two radiologists with more than 10 years of experience, the ResNet-18 and DenseNet-121 deep learning models were selected. Transfer learning was used. 80% of the data was used for training models, 10% was used for validating model performance against overfitting, and the last 10% was used for the final evaluation of the model. Assessment indicators included accuracy, sensitivity, specificity, and AUC values.

Results:

The overall accuracy of ResNet-18 and DenseNet-121 models were 89.64% and 82.5%, respectively. The sensitivity and specificity of identifying five subtypes and normal images were above 0.80. The sensitivity of DenseNet-121 model to recognize intraventricular hemorrhage and cerebral parenchymal hemorrhage was lower than 0.80, 0.73, and 0.76 respectively. The AUC values of the two deep learning models were above 0.9.

Conclusion:

The deep learning model can accurately identify the five subtypes of intracranial hemorrhage and normal images, and it can be used as a new tool for clinical diagnosis in the future.
Measurement of High Protein Concentrations by Optical Rotation: A Case
Study for Monitoring of Monoclonal Antibody Drug Downstream Processes
Authors: Inaba Hidenori , Wakabayashi Kosuke , Tsujimoto Ikuo , Yoshimoto Noriko , Yamamoto Shuichi
Published: December 2021

Background:

Recent advancements in cell engineering and bioreactor engineering have enabled
high monoclonal antibody (mAb) concentrations in harvested solutions for the downstream process
(DSP).

Methods:

As many unit operations such as capture chromatography, polish chromatography, membrane
filtration, virus inactivation, virus filtration, and concentration by ultrafiltration are involved in DSP, it
is crucial to monitor the process carefully in order to perform reliable and stable DSP operations. One of
the most important signals (process parameter) to be monitored is the protein concentration CP. Although
various methods are available, most of them are not suited for measuring high CP. In this paper,
we have developed a method for measuring very high CP by optical rotation (OR).

Result:

Linear correlations were confirmed between OR and CP in the range CP = 0 to 80 g/L for mAbs
with high repeatability and small variation coefficients. This method was applied to the monitoring of CP
in the opaque (colored) solution during the cell culture. The CP by OR was in good agreement with those
by the standard Protein A HPLC method.

Conclusion:

Monitoring of high CP by OR is expected to be an efficient process analytical tool (PAT)
for DSP.
Recent Approaches and Success of Liposome-Based Nano Drug Carriers
for the Treatment of Brain Tumor
Authors: Shaw Tapan Kumar , Paul Paramita
Published: December 2021

:

Brain tumors are nothing but a collection of neoplasms that originate either from areas
within the brain or from systemic metastasized tumors of other organs spread to the brain. It is a
leading cause of death worldwide. The presence of the blood-brain barrier (BBB), blood-brain tumor
barrier (BBTB), and some other factors may limit the entry of many potential therapeutics into
the brain tissues in the tumor area at the therapeutic concentration required for satisfying effectiveness.
Liposomes play an active role in delivering many drugs through BBB into the tumor due to
their nanosize and physiological compatibility. The surface of the liposomes can be modified with
various ligands that are very specific to the numerous receptors overexpressed onto the BBB as
well as onto the diseased tumor surface site (i.e., BBTB) to deliver selective drugs into the tumor
site. Further, this colloidal carrier can encapsulate both lipophilic and hydrophilic drugs due to its
unique structure. Moreover, the enhanced permeability and retention (EPR) effect can be an added
advantage for nanosize liposomes to concentrate into the tumor microenvironment through relatively
leaky vasculature of solid tumor in the brain where no penetration restriction applies compared
to normal BBB. Here in this review, we have tried to compile the recent advancement along with
the associated challenges of liposomes containing different anti-cancer chemotherapeutics across
the BBB/BBTB for the treatment of gliomas that will be very helpful for the readers for better understanding
of different trends of brain tumor targeted liposomes-based drug delivery and for pursuing
fruitful research on the similar research domain.
Extended Application of Digital Clock Drawing Test in the Evaluation of
Alzheimer’s Disease Based on Artificial Intelligence and the Neural Basis
Authors: Zheng Xiaoran , Zhang Wei , Wang Xing , Li Renren , Liu Meng , Xu Feiyang , Li Yunxia , Zheng Jialin , Nie Zhiyu
Published: December 2021

Introduction:

This study aimed to build the supervised learning model to predict the state of cognitive impairment, Alzheimer’s Disease (AD) and cognitive domains including memory, language, action, and visuospatial based on Digital Clock Drawing Test (dCDT) precisely.

Methods:

207 normal controls, 242 Mild Cognitive Impairment (MCI) patients, 87 dementia patients, including 53 AD patients, were selected from Shanghai Tongji Hospital. The electromagnetic tablets were used to collect the trajectory points of dCDT. By combining dynamic process and static results, different types of features were extracted, and the prediction models were built based on the feature selection approaches and machine learning methods.

Results:

The optimal AUC of cognitive impairment’s screening, AD’s screening and differentiation are 0.782, 0.919 and 0.818, respectively. In addition, the cognitive state of the domains with the best prediction result based on the features of dCDT is action with the optimal AUC 0.794, while the other three cognitive domains got the prediction results between 0.744-0.755.

Discussion:

By extracting dCDT features, cognitive impairment and AD patients can be identified early. Through dCDT feature extraction, a prediction model of single cognitive domain damage can be established.
Hydroxychloroquine (HCQ) Exhibits Better Binding to the Main Protease (Mpro) Compared to Spike Protein (S protein) of SARS-CoV-2: An In-silico Analysis
Authors: Bandi Deepa R. , Tulimilli SubbaRao V. , Kumar T. Durai Ananda , Chitturi Chandi Kumari , Bettadapura Anjalidevi S. , Natraj Suma M. , Madhunapantula SubbaRao V.
Published: December 2021

Background:

Despite various efforts in preventing and treating SARS-CoV-2 infections;
transmission and mortality have been increasing at alarming rates globally. Since its first occurrence
in Wuhan, China, in December 2019, the number of cases and deaths due to SARS-CoV-
-2 infection continues to increase across 220 countries. Currently, there are about 228 million cases
and 4.6 million deaths recorded globally. Although several vaccines/drugs have been reported to
prevent or treat SARS-CoV-2, their efficacy to protect against emerging variants and duration of
protection are not fully known. Hence, more emphasis is given to repurpose the existing pharmacological
agents to manage the infected individuals. One such agent is hydroxychloroquine (HCQ),
which is a more soluble derivative of antimalarial drug chloroquine. HCQ has been tested in clinical
trials to mitigate SARS-CoV-2 infection-induced complications while reducing the time to clinical
recovery (TTCR). However, several concerns and questions about the utility and efficacy of
HCQ for treating SARS-CoV-2 infected individuals still persist. Identifying key proteins regulated
by HCQ is likely to provide vital clues required to address these concerns.

Objective:

The objective of this study is to identify the ability of HCQ for binding to the most widely
studied molecular targets of SARS-CoV-2 viz., spike glycoprotein (S protein), and main protease
(Mpro, also referred as chymotrypsin like protease) using molecular docking approaches and
correlate the results with reported mechanisms of actions of HCQ.

Methods:

X-ray crystallographic structures of spike glycoprotein and main protease of SARSCoV-
2 were retrieved from Research Collaboratory for Structural Bioinformatics (RCSB) Protein
Data Bank (PDB). The structure of Hydroxychloroquine was retrieved from the PubChem compound
database. The binding interactions of the HCQ with target proteins were predicted using CDocker
algorithm, and visualized using Discovery studio visualizer.

Results:

Data from molecular docking studies showed very strong binding of HCQ to the main protease
compared to spike glycoprotein.

Conclusion:

The antiviral activity of HCQ is attributed to its ability to bind to the main protease
compared to surface glycoprotein. Therefore, future studies should focus more on developing a
combination agent/strategy for targeting surface glycoprotein and main protease together.
One-Pot Access to 2-oxazolines via a Castro-Stephens Coupling and Intramolecular
Cyclization
Authors: Nighot Dnyaneshwar , Rawat Varun , Jain Arvind K. , Ali Imran
Published: December 2021

Aim:

Here, we have reported easy one-pot access to a series of oxazolines using a modified
Castro-Stephens coupling protocol.

Background:

2-oxazolines have been shown to have significant biological activity and wide-ranging
applications in organic chemistry. These properties make oxazolines as heterocyclic compounds
of immense importance.

Objective:

The objective of this study is to synthesize oxazoline derivatives via an economical and
one-pot protocol.

Method:

2-oxazoline has been synthesized through Cu-powder mediated Castro-Stephens coupling
and intramolecular cyclization route. The mechanism involves a rearrangement in which one
of the oxygen from the N-acylamino alcohol group is liberated as water and then transferred to
alkyne functionality to form 2-oxazoline derivatives. The oxazolines were characterized by NMR,
mass, and XRD studies.

Result:

The protocol is economically viable and uses readily available Cu-powder along with
DMF for cross-coupling and cyclization steps.

Conclusion:

We have reported a one-pot protocol to prepare 2-oxazolines using a Castro-Stephens
coupling and intramolecular cyclization.
The Experience of Depression Relapse among Adult Thai Patients
with Depressive Disorder: A Qualitative Study
Authors: Muijeen Kasorn , Soonthornchaiya Rangsiman , Butcher Howard K.
Published: December 2021

Background:

Depression is an illness with widespread incidence and
has shown an annual increase, while depression relapse is also rising continually
due to multiple causes. In Thailand, although many studies have been conducted
to prevent depression incidence and relapse, there is little known about the meaning
of depression relapse in adult Thai patients. An exploration of the direct experiences
of adult Thai patients seems a suitable way to gather data for a care system
development.

Objectives:

The purpose of this study is to describe the perceptions of adult Thai
patients concerning their experience of depression relapse and its management
among adult patients with depressive disorder in the Thai context.

Methods:

This research is a qualitative study using the directed content analysis
approach. In-depth interviews with 20 adult Thai patients with depression that
had direct experience with depression relapse were the participants used in this
study. The interviews allowed the participants to talk about their experiences
with depression relapse and how they managed depressive symptoms; the interviews
lasted approximately 60 minutes.

Results:

Two themes emerged from the study. First, the experience of depression
relapse is the feeling pulled away from happiness. Second, managing depression
relapse.

Conclusion:

Depression relapse among adult Thai patients with depressive disorder
is an experience causing patients to feel that they are losing their happiness
again. Care and management of depression relapse by each patient differ, despite
being in the same social contexts. Therefore, depression relapse risk assessment
is important in the care of each patient in order to design more effective care.
Quality of Life in Family Caregivers of Patients with Schizophrenia:
A Narrative Review
Authors: Völker Jes Sebastian , Micluția Ioana Valentina
Published: December 2021

Care for schizophrenia patients over the past few decades has shifted
from inpatient treatment in mental institutions towards outpatient treatment options.
While this has the potential to allow patients a more regular life with the
ability to work and socialize, it has increased the burden on family caregivers.
This state-of-the-art narrative review summarizes the most important factors, besides
the clinical symptoms of schizophrenia, that impact the quality of life of
caregivers negatively. These factors include the impact of the disease on household
income and socioeconomic status, anxiety, stigma, negative changes in family
dynamics as well as an overall reduction of social and family contacts.
Improving speaking skill for technical students at IUH through experiential activities
Authors: Minh Nhat Truong Tran , Kim Oanh Duong Thi
Published: December 2021

Nowadays, English is one of the most important languages in Vietnam, so students at all levels in Vietnam have been studying English as a compulsory subject with special attention to speaking skills to communicate and work in the integration world. However, speaking skill is still strongly not successful with students, especially technical students at universities. Therefore, this small-scale research aims to investigate the difficulties which technical students at IUH usually faced when practicing the skill, and the efficiency of experiential activities in improving learners' speaking skills. This research used quasi-experimental method. The sample of the research is 120 technical students in 4 English classes in the second semester of the school year. After distributing a questionnaire to 120 technical students at IUH, the findings indicated that speaking skill is essentially evaluated by most of the students, although they still have some difficulties when practicing. It was also evident that students were interested in experiential activities which were applied to improve students' skills, such as watching films and telling opinions, role play, communicate in group work, and so on. These activities not only enhance students' positive motivation in studying English and speaking skills but also improve their communicative skills.
Indonesian language teaching in elementary school
Authors: Khair Ummul , Rihan K Eka , Misnawati Misnawati
Published: December 2021

In learning activities, there is often a learning saturation that arises from students. This can be triggered by various things. Therefore, as a researcher, he took the initiative to apply modeling in learning, especially in language learning. Thus, the purpose of this research is the application of an explicit type of cooperative learning model instructions chronological technique of events in writing narratives from interview texts. This research is applied or piloted to students consisting of several schools in Indonesia as well as the object of research. The research instrument is the researcher himself as the key/main instrument. In addition, the researcher was also assisted by several other teams of research students and teachers from local schools. Based on the results of research through testing the model, it is categorized that there is a significant increase in learning. It can be seen that the average score of students reaches 85% of the maximum threshold of 90%. Thus, it can be concluded that the application of the model is considered successful and can be applied in various schools in the world.
Exclusive breastfeeding practice and sources of support during COVID-19 pandemic in Indonesia
Authors: Agustin Cahya Ayu , Februhartanty Judhiastuty , Bardosono Saptawati
Published: December 2021

In 2018, the national coverage of exclusive breastfeeding among infants aged 0-5 months in Indonesia was still low. The COVID-19 pandemic can be a challenge to increase the coverage of exclusive breastfeeding. This study investigated the association between sources of breastfeeding supports and exclusive breastfeeding practices among mothers with infants aged under 6 months during the COVID-19 pandemic in Indonesia. This study used a cross-sectional study design through an online survey from November 2, 2020, to February 8, 2021. A total of 248 subjects were obtained through convenience sampling. Data analysis was done by bivariate analysis using Chi-square or Fisherâ€™s exact test. Most of the subjects were aged 18-34 years old (90.7%), had higher education level (86.7%), had household income range Rp.3,000,000 â€“ Rp.7,199,999 (39.2%), lived in Java Island (83.1%), had an infant aged â‰¤ 4 months (76.2%), and had a baby boy (51.2%). The proportion of exclusive breastfeeding was 79.0%. The most common sources of breastfeeding support were obtained from husband (91.1%) and health workers (65.7%), followed by family (62.9%). No significant association was found among all support sources on breastfeeding with exclusive breastfeeding. However, the proportion of exclusive breastfeeding among mothers who received husband support (80.1%) was higher than those who did not (68.2%). The most convenient and feasible breastfeeding supports that mother could obtain during pandemics were home-based supports. Mothers, their husbands, and families should be the priority target for health professionals to provide preventive and promotive breastfeeding intervention.
Maternal Attributes and Child Minimum Acceptable Diet during COVID-19 Pandemic in Indonesia
Authors: Fadlina Athiya , Februhartanty Judhiastuty , Bardosono Saptawati
Published: December 2021

Appropriate complementary feeding practices must be sustained during the COVID-19 pandemic for optimal growth and development of a child. However, the studies assessing factors associated with complementary feeding practices during COVID-19 are still limited. The objective of this study was to evaluate maternal attributes and minimum acceptable diet (MAD) of 6-11-month-old children during the COVID-19 pandemic in Indonesia. This study was part of the â€œCOVID-19 Mom-Infant Studyâ€ and was conducted in all regions of Indonesia using an online survey. Chi-square or Fisher's exact test was performed to examine the relationship between MAD and maternal attributes, with a significant level at p-value <0.05. From a total of 262 data collected, 74%, 77.1%, 94.3% of the children aged 6-11 months have met MAD, MDD (minimum dietary diversity), and MMF (minimum meal frequency), respectively. Motherâ€™s education level (OR= 3.625; 95%CI [1.805 â€“ 7.280]) and working status (OR= 2.197; 95%CI [1.291 â€“ 3.895] were found associated with childâ€™s MAD. One-third of children did not receive the recommended infant and young children feeding practices. Conducting nutrition interventions to mothers with lower education and not working should be a priority under these circumstances.
Kepatuhan Diet Berbasis Beras Coklat terhadap Glukosa Darah dan Lemak Tubuh Pasien Diabetes Mellitus
Authors: Kusumastuty Inggita , Handayani Dian , Affandy Yeni Intan Kusuma Dewi , Attamimi Nora , Innayah Alma Maghfirotun , Puspitasari Diah Ayu
Published: December 2021

Beras coklat memiliki kandungan magnesium, serat lebih tinggi dan indeks glikemik lebih rendah dari beras putih, diduga dapat mencegah kenaikan glukosa darah dan menurunkan lemak tubuh. Tujuan penelitian ini untuk mengetahui hubungan antara kepatuhan diet berbasis beras coklat dengan kadar glukosa darah puasa dan komposisi lemak tubuh pada pasien Diabetes Mellitus (DM) Tipe 2. Penelitian ini merupakan penelitian quasi experimental dengan rancangan one group pre test and post test design pada 18 pasien DM Tipe 2 yang memenuhi kriteria inklusi. Responden penelitian diberikan intervensi selama 3 bulan berturut. Pemeriksaan glukosa darah puasa dan komposisi lemak tubuh dilakukan sebelum dan setelah intervensi diberikan. Selama pemberian intervensi diet, 94.4% responden patuh diet. Setelah intervensi diberikan terjadi penurunan kontrol glukosa darah dari kategori buruk sebesar 27.7%, persentase lemak tubuh kategori tinggi sebesar 22.2% dan indeks lemak viseral kategori tinggi sebesar 22.2%, namun tidak terdapat hubungan antara kepatuhan diet dengan glukosa darah puasa, total lemak tubuh dan lemak visceral (p=0.339, p= 0.496, p=0.551, spearman). Kesimpulan dari penelitian ini bahwa pemberian diet berbasis beras coklat pada pasien DM Tipe 2 dapat menurunkan kadar glukosa darah puasa dan komposisi lemak tubuh namun tidak terdapat hubungan antara kepatuhan diet dengan ketiga parameter tersebut.
A Systematic Literature Review: Fuel subsidy and consumer environmental awareness in urban road transport
Authors: Mhd Noh Nor Aziedah , Mohd Abdul Kadir Juliana , Ramli Ahmad Razi , Hamdan Rosita
Published: December 2021

Using a systematic literature review, we explore fuel subsidies and consumer environmental awareness among users in urban road transport. Fuel subsidies given by the government to the public have to some extent brought them to more using own transport as the fuel cost is now cheaper. A growing number of vehicles and usage in the urban road transport sector worldwide has increased CO2 emissions and impact on environment. The misalignment of benefits from the implementation of fossil fuel subsidies and high emissions has grown attention to limit global warming since the Paris Agreement 2015 was signed. Nonetheless, consumer environmental awareness is interesting to bring forward for future research.
Keywords: Fuel Subsidy, Consumer Environmental Awareness, Urban Road Transport, Systematic Literature Review
eISSN: 2398-4287© 2021. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians/Africans/Arabians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v6i18.3097
Impact of a Personal Health Record Intervention upon Surveillance Among Colorectal Cancer Survivors: Feasibility Study (Preprint)
Authors: Vachon Eric , Robb Bruce W. , Haggstrom David A.
Published: December 2021

BACKGROUND

There are currently an estimated 1.5 million individuals living in the United States (US) with colorectal cancer (CRC), and although the five-year survival rate has increased, survivors are at risk for recurrence, particularly within the first 2-3 post-treatment. National guidelines recommend continued surveillance post-resection, in order to identify recurrence early on. Adherence among survivors ranges from 49%-94%. Novel interventions are needed to increase CRC survivors’ knowledge and confidence in managing their cancer and thus increase adherence to follow-up surveillance.

OBJECTIVE

The objective of this study was to develop and test the feasibility and efficacy of a web-based personal health record (PHR) to increase surveillance adherence among CRC survivors, with patient beliefs about surveillance as secondary outcomes.

METHODS

A pre- and post-intervention feasibility trial was conducted testing the efficacy of the Colorectal Cancer Survivor (CRCS)-PHR, which had been previously developed using an iterative, user-centered design approach. The CRCS-PHR includes surveillance guidelines, treatment tracking, potential treatment toxicities, as well as a journaling tab and communities to interact with other CRC survivors. A total of 28 stage I-III CRC survivors (9 colon, 18 rectal, 1 unknown) were recruited from an academic medical center in the Midwest US. At enrollment, patient demographics and cancer characteristics were gathered via medical record audit. Following enrollment, patients completed surveys at baseline and 6 months post-intervention asking about adherence to colonoscopy, computed tomography (CT) scan, and carcinoembryonic antigen (CEA) and beliefs about surveillance (barriers, benefits, self-efficacy, and knowledge). Paired t-test analyses were used to compare pre- and post-intervention ratings for each of the four patient beliefs categories and surveillance adherence.

RESULTS

The average age of the sample was 58 years old, with 57% males and the majority being married and employed full time. We observed a significant increase in adherence to colonoscopy (pre: 52% vs. post: 86%, p<.01) and CEA (67% vs. 95%, p=.01), as well as a slight increase in CT scans (67% vs. 84%, p=.1). The only significant impact on secondary outcome (patient beliefs) was benefits of CEA test (p=.04), as most of the beliefs were high at baseline.

CONCLUSIONS

This feasibility study lays the groundwork for continued development of the CRCS-PHR to increase CRC surveillance. Patient-centered technologies, such as the CRCS-PHR, represent an important potential approach to improving the receipt of guideline-concordant care and follow-up surveillance, not just for CRC survivors. Researchers should continue to develop patient-centered health technologies with clinician implementation in mind to increase patient self-efficacy and surveillance adherence.
Assessing a Digital Medicine System in Veterans with Severe Mental Illness: A provider-randomized clinical trial (Preprint)
Authors: Gonzales Sarah , Okusaga Olaoluwa O. , Reuteman-Fowler J. Corey , Oakes Megan M. , Brown Jamie N. , Moore Scott , Lewinski Allison A. , Rodriguez Cristin , Moncayo Norma , Smith Valerie A. , Malone Shauna , List Justine , Cho Raymond Y. , Jeffreys Amy S. , Bosworth Hayden B.
Published: December 2021

BACKGROUND

Suboptimal medication adherence is a significant problem for patients with serious mental illness (SMI). Measuring medication adherence through subjective and objective measures can be challenging, time consuming and inaccurate.

OBJECTIVE

We evaluated a digital medicine system (DMS) compared to treatment as usual (TAU) on adherence to oral aripiprazole and patient and provider perspectives on the feasibility and acceptability of a DMS.

METHODS

This open-label, 2-site, provider-randomized trial assessed aripiprazole refill adherence in Veterans with schizophrenia, schizoaffective disorder, bipolar disorder, or major depressive disorder. We randomized 26 providers such that their patients either received TAU or DMS for a period of 90 days. Semi-structured interviews with patients and providers were used to examine feasibility and acceptability of using the DMS.

RESULTS

We enrolled 46 patients across 2 Veterans Affairs (VA) sites: (21 in DMS and 25 in TAU). There was no difference in medication refill over 3 and 6 months, respectively (82% and 75% DMS vs. 86% and 82% TAU). The DMS arm had 85% days covered during the period they were engaged with the DMS (144 days on average). Interviews with patients (n=14) and providers (n=5) elicited themes salient to using the DMS. Patient themes included: pre-enrollment adherence strategies and interest in the DMS, positive impact on medication adherence, system usability challenges, support needs, and suggested design/functionality improvements. Provider themes included: concerns for patient medication adherence and interest in the DMS, concerns with the DMS, DMS dashboard usability, challenges of the DMS, and suggestions to increase provider use.

CONCLUSIONS

There was no observed difference in refill rates. Among those who engaged in the DMS arm, refill rates were relatively high (85%). The qualitative analyses highlighted areas for further refinement of the DMS.

CLINICALTRIAL

NCT03881449
Preparation of Biodegradable and Low-Cost Lignin-Based PVOH Carbon Fibers Prepared by Electrospinning
Authors: Siregar Amir Hamzah , Warman Aditia , Harahap Mahyuni , Nainggolan Grace , Dellyansyah Dellyansyah , Gea Saharman
Published: December 2021

A polyvinyl alcohol (PVOH)/lignin nanofiber was prepared by the electrospinning method as a precursor for biodegradable and low-cost carbon fibers. PVOH 15% was dissolved in water, and various concentration of lignin (5, 10, 15, 20, and 25%) was added. The presence of lignin in PVOH solution increased the viscosity and conductivity. From SEM analysis, PVOH solution produced smooth fiber, whereas the addition of lignin produced fibers in bead forms. The presence of lignin above 20% in PVOH did not produce spun-fiber. FTIR analysis confirmed that lignin was able to form hydrogen bonds with PVOH. TGA analysis showed that PVOH/lignin nanofibers had the highest residual mass, i.e., 40% at 600 °C. The morphology of the carbon fibers showed flake forms with many pores and had 58.07% carbon content.
A Comparison of the Effectiveness of the RRT, PRM, and Novel Hybrid RRT-PRM Path Planners
Authors: Jermyn Jacqueline
Published: December 2021

Abstract: Sampling-based path planners develop paths for robots to journey to their destinations. The two main types of sampling-based techniques are the probabilistic roadmap (PRM) and the Rapidly Exploring Random Tree (RRT). PRMs are multi-query methods that construct roadmaps to find routes, while RRTs are single-query techniques that grow search trees to find paths. This investigation evaluated the effectiveness of the PRM, the RRT, and the novel Hybrid RRT-PRM methods. This novel path planner was developed to improve the performance of the RRT and PRM techniques. It is a fusion of the RRT and PRM methods, and its goal is to reduce the path length. Experiments were conducted to evaluate the effectiveness of these path planners. The performance metrics included the path length, runtime, number of nodes in the path, number of nodes in the search tree or roadmap, and the number of iterations required to obtain the path. Results showed that the Hybrid RRT-PRM method was more effective than the PRM and RRT techniques because of the shorter path length. This new technique searched for a path in the convex hull region, which is a subset of the search area near to the start and end locations. The roadmap for the Hybrid RRT-PRM could also be re-used to find pathways for other sets of initial and final positions. Keywords: Path Planning, Sampling-based algorithms, search tree, roadmap, single-query planners, multi-query planners, Rapidly Exploring Random Tree (RRT), Probabilistic Roadmap (PRM), Hybrid RRT-PRM
Zomato Data Analysis
Authors: Saxena Arpit
Published: December 2021

Abstract: Whenever we would like to visit a brand new place in delhi -NCR, we often search for the most effective restaurant or the most cost effective restaurant, but of decent quality. For looking of our greatest restaurants we frequently goes for various websites and apps to induce an overall idea of restaurants service. the foremost important criteria for all this is often rating and reviews of the those that have already got experience in these restaurants. People see for rating and compare these restaurants with one another and choose for his or her best. We restrict our data only to Delhi-NCR. This Zomato dataset provides us with enough information in order that one can decide which restaurants is suitable at which place and what kind of food they must serve so as get maximum profit. it's 9552 rows and 22 columns during this dataset. We'd wish to find the most affordable restaurant in Delhi-NCR.We can discuss various relationships between various columns of information sets like between rating and cuisine type , locality and cuisine etc. Since it's a true time data we might start first with data cleaning like cleaning spaces , garbage texts etc , then data exploratory like handling the None values, null values, dropping duplicates and other Transformations then randomization of dataset so analysis. Our target variable is that the "Aggregate Rating" column. We explore the link of the opposite features within the dataset with relevancy Rates. we'll the visualize the relation of all the opposite depend features with relevance our target variable, and hence find the foremost correlated features which effects our target variable. Keywords: Online food delivery, Marketing mix strategies, Competitive analysis, Pre-processing, Data Cleaning, Data Mining, Exploratory data analysis , Classification , Pandas , MatPlotLib.