bluuebunny/crossref_metadata_2025 huggingface dataset:
CRISP(R)ation musculaire
Authors: Ballouhey Océane , Bartoli Marc , Levy Nicolas
Published: May 2020

Les dystrophies musculaires sont un ensemble de pathologies musculaires rares, caractérisées par une faiblesse et une dégénérescence progressive du muscle. Ce sont des maladies d’origine génétique causées par la mutation d’un ou de plusieurs gènes impliqués dans les fonctions musculaires. Malgré des progrès significatifs réalisés dans le champ des biothérapies au cours des dernières années, il n’existe pas, à ce jour, de traitement curatif disponible pour ces pathologies. Les études menées depuis la découverte de l’outil d’édition génomique CRISPR-Cas9 ont néanmoins permis des avancées significatives et prometteuses dans le traitement des dystrophies musculaires. Le système CRISPR-Cas9 permet une édition stable et permanente du génome et doit permettre d’éviter les traitements longs et répétitifs. Dans cette revue, nous aborderons les dernières avancées thérapeutiques utilisant le système CRISPR-Cas9 dans le cadre des dystrophies musculaires d’origine génétique.
95 Jahre Universitäts-Hautklinik Jena: Geschichte und Gegenwart
Authors: Reddersen K. , Burmester A. , Dieckmeyer C. , Engelmann C. , Goetze S. , Gregersen D. , Hipler U.-C. , Ludriksone L. , Peckruhn M. , Schliemann S. , Tittelbach J. , Wiegand C. , Elsner P.
Published: May 2020

Anlässlich des 95-jährigen Jubiläums der Universitäts-Hautklinik Jena beleuchtet dieser Beitrag die historische Entwicklung des Hauses in den verschiedenen politischen Systemen des letzten Jahrhunderts sowie die aktuelle Situation der Klinik als Teil des Universitätsklinikums Jena. Verschiedene Klinikleitungen in der Vergangenheit prägten die Ausrichtung des Hauses in Bezug auf Therapie und Forschung und setzten Schwerpunkte auf Themen wie Phototherapie, Autoimmunerkrankungen, Dermatoonkologie, Andrologie und Biomaterialforschung. Die Universitäts-Hautklinik vereint neben hochqualitativer Patientenversorgung und Lehre umfangreiche Forschungsaktivitäten.
Der Einfluss von MS-spezifischen Symptomen auf die gesundheitsbezogene Lebensqualität
Authors: Sander Lydia , Kugler Joachim , Elsner Bernhard
Published: May 2020

Hintergrund Multiple Sklerose (MS) ist eine chronisch progredient verlaufende Erkrankung, welche mit einer Vielzahl von MS-spezifischen Symptomen einhergeht. Viele dieser Symptome wirken sich negativ auf die gesundheitsbezogene Lebensqualität (Health Related Quality of Life, HRQoL) der Betroffenen aus. Bisher ungeklärt ist, welche MS-spezifischen Symptome einen besonders großen Einfluss auf die HRQoL haben.

Methodik Die durchgeführte Untersuchung basiert auf den Daten einer Mitgliederbefragung der Deutschen MS Gesellschaft (DMSG) im Jahr 2015 (n = 424). Unter Berücksichtigung von soziodemographischen Variablen und allgemeinen medizinischen Variablen wurde der Einfluss der MS-spezifischen Symptome auf die HRQoL untersucht. Die HRQoL wurde mit dem Multiple Sclerosis Quality of Life-54-Instrument (MSQOL-54-Instrument) erhoben. In einem Vortest wurden alle Einflussfaktoren auf einen signifikanten Mittelwertunterschied (p = 0,05) bzw. eine mittlere Korrelation (Pearson’s r ≥ 0,3) getestet. Anschließend wurde der Einfluss der im Vortest identifizierten Variablen auf die HRQoL mithilfe der multiplen linearen Regressionsanalyse untersucht.

Ergebnisse Für die Befragten konnte ein durchschnittlicher Physical Health Composite Score (PHCS) von 48,3 (sd = 17,7) und ein durchschnittlicher Mental Health Composite Score von 56,0 (sd = 20,1) errechnet werden. Als wichtigste Einflussfaktoren auf die HRQoL ergeben sich die MS-spezifischen Symptome Depression, Schmerz und kognitive Einschränkungen. MS-bedingte Symptome mit einem Mobilitätskontext zeigen negativen Zusammenhang mit dem PHCS. Sprechstörung und Schwindel sind mit einem abnehmenden MHCS verbunden. Der Beschäftigungsstatus ist der einzige sozioökonomische Faktor, der sich in der multiplen Regression signifikant auf die HRQoL auswirkt. Die allgemeinen medizinischen Faktoren zeigen keinen signifikanten Einfluss auf die HRQoL.

Schlussfolgerung MS-spezifische Symptome haben einen großen Einfluss auf die HRQoL von Menschen mit MS. In der Untersuchung konnte gezeigt werden, dass besonders die sogenannten „versteckten Symptome“ einen wesentlichen Einfluss auf die HRQoL haben. Hier sind beispielsweise die Symptome Depression, Schmerz und kognitive Einschränkungen zu nennen. Diese sollten stärker in der Versorgung von Menschen mit MS berücksichtigt werden.
Factors Influencing the Choice between DOACs and LMWHs: A Survey of German Physicians on the Treatment of Cancer-Associated Venous Thromboembolism
Authors: Matzdorff Axel , Langer Florian
Published: May 2020

Recently direct-acting oral anticoagulants (DOACs) have become a new therapeutic option besides parenteral anticoagulants to treat cancer-associated venous thromboembolism (VTE). With this survey we wanted to identify factors influencing the choice between low-molecular-weight heparin and DOACs among physicians treating cancer patients. A questionnaire was presented at several medical educational activities on cancer care and VTE management between August 2018 and January 2019. One hundred fifteen physicians returned their surveys. The two most compelling arguments pro DOAC were when the patient had no chemotherapy and when he expressed unwillingness to apply injections. The two most important arguments against DOACs were if the patient had problems with taking oral medications or when he had a history of severe bleeding. This survey shows that future studies need to consider many more factors, particularly patient preferences and physician concerns on bleeding risk, to improve their applicability in daily practice.
The Epidemiology of Traumatic Brain Injury Due to Traffic Accidents in Latin America: A Narrative Review
Authors: Dunne Jack , Quiñones-Ossa Gabriel Alexander , Still Ethne Grey , Suarez María N. , González-Soto José A. , Vera David S. , Rubiano Andrés M.
Published: May 2020

Objective Traumatic brain injuries (TBIs) are devastating injuries and represent a major cause of morbidity and mortality worldwide. Traffic accidents are one of the main causes, especially in low- and middle-income countries. The epidemiology of TBI due to road traffic in Latin America is not clearly documented.

Methods A narrative review was conducted using PubMed, SCOPUS, and Google Scholar, looking for TBI studies in Latin America published between 2000 and 2018. Seventeen studies were found that met the inclusion and exclusion criteria.

Results  It was found that TBI due to road traffic accidents (RTAs) is more frequent in males between the ages of 15 and 35 years, and patients in motor vehicles accounted for most cases, followed by pedestrians, motorcyclists, and cyclists.

Conclusion Road traffic accidents is a common cause of TBI in Latin America. More studies and registries are needed to properly document the epidemiological profiles of TBI related to RTAs.
Resveratrol Relieves Hyperoxia-Induced Brain Injury in Neonatal Rats by Activating Sirt1
Authors: Kang Lan , Dong Wenbin , Li Xiaobin , Ruan Ying , Zhang Rong
Published: May 2020

Objective Neonatal rats with hyperoxia-induced brain injury were treated with resveratrol to investigate its protective effects through analyzing changes in reactive oxygen species (ROS), Sirt1, p53, and acetylated p53 levels.

Study Design Neonatal rats were randomly divided into hyperoxia and resveratrol intervened groups. Rats in both groups were placed in a hyperoxia chamber for 7 days to induce hyperoxia-induced brain injury. The rats in the resveratrol intervened group were administered resveratrol 60 μg/g body weight daily, whereas those in the hyperoxia group were administered a dimethyl sulfoxide-based solvent. Brain tissues were collected, and hematoxylin and eosin (H&E) and TUNEL staining, ROS measurements, real time-polymerase chain reaction, and western blotting were performed.

Results H&E and TUNEL staining revealed increased cell damage and apoptosis in brain tissue from hyperoxia-exposed animals compared with the findings in animals in the resveratrol intervened group. Real time-polymerase chain reaction and western blotting identified increases in Sirt1 expression and decreases in p53 expression in the resveratrol intervened group. In addition, acetylated p53 protein expression was lower in the intervened group than in the hyperoxia group.

Conclusion Resveratrol alleviated brain apoptosis induced by hyperoxia in neonatal rats by upregulating Sirt1-mediated pathways, suggesting its potentially beneficial role in the treatment of brain injury induced by hyperoxia.
Anisotropy of hydrogen plasma effects in bulk n-type β-Ga2O3
Authors: Polyakov A. Y. , Lee In-Hwan , Miakonkikh Andrew , Chernykh A. V. , Smirnov N. B. , Shchemerov I. V. , Kochkova A. I. , Vasilev A. A. , Pearton S. J.
Published: May 2020

Bulk n-type β-Ga2O3 samples with orientation (−201) and (010) were exposed to a high density hydrogen plasma at 330 °C for 0.5 h. The effects were radically different for the two orientations. For the (−201) sample, H plasma exposure increased the net surface concentration of shallow donors from 2.7 × 1017 cm−3 to 2.6 × 1018 cm−3, with the shallow donors having an ionization energy close to 20 meV as deduced from the temperature dependence of the series resistance of Ni Schottky diodes. By sharp contrast, H plasma exposure of the (010) sample led to a strong decrease in the net shallow donor density from 3.2 × 1017 cm−3 to below 1015 cm−3 in the top 0.9 μm of the sample and to 3.2 × 1016 cm−3 near the edge of the space charge region at 0 V, with the total width of the region affected by plasma treatment being close to 1.1 μm. For both orientations, we observed a major decrease in the concentration of the dominant E2 traps near Ec-0.82 eV related to Fe acceptors. The deep trap spectra in hydrogenated samples were dominated by the E2* traps commonly ascribed to native defects in β-Ga2O3. The peak of these traps with a level near Ec-0.74 eV was masked in the starting samples by the peak of the E2 Fe acceptors present in high concentration, so that E2* only broadened the Fe peak on the low temperature side, but could be revealed by the modeling of the spectra. The concentration of the E2* center was not strongly affected in the hydrogen-treated samples with orientation (010), but in the (−201) samples, the concentration of the E2* peak was greatly enhanced. The results are discussed in conjunction with previous reports on hydrogen plasma treatment of β-Ga2O3 and on obtaining p-type conductivity in the surface layers of β-Ga2O3 crystals annealed in molecular hydrogen at high temperatures [Islam et al., Sci. Rep. 10, 6134 (2020)].
A miniature thermal neutron source using high power lasers
Authors: Mirfayzi S. R. , Ahmed H. , Doria D. , Alejo A. , Ansell S. , Clarke R. J. , Gonzalez-Izquierdo B. , Hadjisolomou P. , Heathcote R. , Hodge T. , Martin P. , Raspino D. , Schooneveld E. , McKenna P. , Rhodes N. J. , Neely D. , Borghesi M. , Kar S.
Published: May 2020

The continuous improvement of high power laser technologies is recasting the prospects of small-scale neutron sources to enable scientific communities and industries performing experiments that are currently offered at extensive accelerator-driven facilities. This paper reports moderation of laser-driven fast neutrons to thermal energies using a compact, modular, moderator assembly. A significant thermal (∼25 meV) flux of ∼106 n/sr/pulse was measured from water and plastic moderators in a proof-of-principle experiment employing a relatively moderate power laser delivering 200 J on the target in 10 ps. Using Monte Carlo N-Particle eXtended simulations, the experimental results are reproduced and discussed.
Janus nanoparticle synthesis: Overview, recent developments, and applications
Authors: Safaie Niloofar , Ferrier Robert C.
Published: May 2020

Janus nanoparticles (JNPs) have two faces with differing physical or chemical characteristics which endow them with unique properties. This anisotropy can lead to phenomena like self-assembly or interfacial activity, and JNPs have been under intense scientific scrutiny since the 1990s. Since then, powerful synthetic techniques have been developed which allow for JNPs with near limitless combinations of materials, properties, and morphologies. As such, JNPs have been featured in a number of applications such as drug delivery, catalysis, interfacial engineering, and optics. This perspective discusses the synthesis of these important anisotropic materials. We will focus exclusively on JNPs that involve polymers. In particular, we outline the various classes of JNP synthetic techniques including some historical context, describe recent developments in this area, and weigh the pros and cons of the different methods with an eye on future directions and applications. We hope this perspective will help acclimate those new to the field who want to make and/or use JNPs.
Influence of the phase transitions of shock-loaded tin on microjetting and ejecta production using molecular dynamics simulations
Authors: Durand O. , Soulard L. , Colombet L. , Prat R.
Published: May 2020

We perform very large scale molecular dynamics (MD) simulations to investigate the ejection process from shock-loaded tin surfaces in regimes where the metal first undergoes solid to solid phase transitions and then melts on release. In these conditions, a classical two-wave structure propagates within the metal. When it interacts with the surface, our MD simulations reveal very different behaviors. If the surface geometry is perfectly flat or contains almost flat perturbations (sinusoidal type), a solid cap made of crystallites forms at the free surface, over a thickness of a few tens of nanometers. This surface cap melts more slowly than the bulk, and as a result, the ejection process is greatly slowed down. If the surface geometry contains V-shape geometrical perturbations, the oblique interaction of the incident shock wave with the planar interface of the defect leads to a sharp increase of temperature at the defect's bottom. At this place, the metal undergoes a solid to liquid phase change over the entire length of the groove, and this promotes the ejection of matter in the form of sheets of liquid metal. However, this phase change is not spatially uniform, and the sheets keep in memory this process by exhibiting a non-uniform leading edge and large ripples. These ripples grow over time, which ends up causing the fragmentation of the sheets as they develop. In this case, the fragmentation is non-uniform, and it differs from the rather uniform fragmentation process observed when the metal directly melts upon receiving the shock.
Machine learning approach for describing vibrational solvatochromism
Authors: Kwac Kijeong , Cho Minhaeng
Published: May 2020

Machine learning is becoming a more and more versatile tool describing condensed matter systems. Here, we employ the feed-forward and the convolutional neural networks to describe the frequency shifts of the amide I mode vibration of N-methylacetamide (NMA) in water. For a given dataset of configurations of an NMA molecule solvated by water, we obtained comparable or improved results for describing vibrational solvatochromic frequency shift with the neural network approach, compared to the previously developed differential evolution algorithm approach. We compared the performance of the atom centered symmetry functions (ACSFs) and simple polynomial functions as descriptors for the solvated system and found that the polynomial function performs better than the ACSFs employed in the description of the amide I vibrational solvatochromism.
Extending the operation range of a phase-sensitive optical time-domain reflectometer by using fibre with chirped Bragg gratings
Authors: Kharasov D.R. , Bengalskii D.M. , Vyatkin M.Yu. , Nanii O.E. , Fomiryakov E.A. , Nikitin S.P. , Popov S.M. , Chamorovsky Yu.K. , Treshchikov V.N.
Published: May 2020

>A record long external-disturbance detection distance of 140 km without employing optical amplifiers in the fibre line is demonstrated by a phase-sensitive optical time-domain reflectometer (Φ-OTDR) using a fibre section with inscribed chirped fibre Bragg gratings (CFBGs). This solution provides simultaneous operation of Φ-OTDR with a standard single-mode fibre at a distance of up to 100 km and with a CFBG fibre section located from the fibre line input point by at least 140 km.
Reclassification of velvet antler portions following transcriptomic analysis
Authors: Qin Tao , Wei Guanning , Zhao Haiping , Li Yong , Ba Hengxing , Li Chunyi
Published: May 2020

Context
Commercially, velvet antlers along the longitudinal axis are divided into four portions, namely, wax-like (WL), blood-colour (BC), honeycomb-like (HL) and bone (B) slices from the top to the base. However, there is no evidence at a molecular level showing the accuracy of this classification.

Aims
The aim of the present study was to take transcriptional approach to assess the accuracy of the traditional classification for these four portions of velvet antler, and to link the expressed mRNAs of each portion with possible functions by using bioinformatics analysis.

Methods
Three sticks of three-branched velvet antlers of sika deer were harvested from three anaesthetised 4-year-old sika deer. On the basis of the traditional methods used commercially, the velvet antler sticks were divided into the four portions of WL, BC, HL and B. Transcriptome sequencing was performed using Illumina HiSeq × Ten at BGI (Shenzheng, China).

Key results
In total, 5647 genes were obtained from the four portions. Spearman correlation analysis grouped these four portions into three clusters (WL, BC, HL+B). C-means analysis further confirmed a similar trend, indicating the accuracy of the new classification based on transcriptome analysis. Further functional analysis showed that highly expressed genes in WL, BC and HL+B were mainly related to cell cycle, cartilage development, and bone development respectively.

Conclusions
Four-portion classification based on traditional methods should be replaced by three-portion classification based on the mRNA expression levels.

Implications
We believe that this new classification can contribute to velvet antler industry, providing more accuracy in the use of velvet antlers as pharmaceuticals.
Allosteric conformational change of a cyclic nucleotide-gated ion channel revealed by DEER spectroscopy
Authors: Evans Eric G. B. , Morgan Jacob L. W. , DiMaio Frank , Zagotta William N. , Stoll Stefan
Published: May 2020

Significance

Cyclic nucleotide-gated (CNG) and hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channels generate the primary electrical signals underlying mammalian phototransduction, olfaction, and cardiac pacemaking. These channels activate upon binding of cyclic nucleotide ligands (cAMP and/or cGMP), but the allosteric mechanism that couples ligand binding to gating is not well understood. Using double electron-electron resonance (DEER) spectroscopy, we reveal an allosteric conformational transition in the bacterial CNG channel SthK upon cAMP binding that involves outward movement of the C-linker domain in relation to the pore axis. Computational models constrained by DEER data also predict an upward movement of the cytoplasmic domain toward the membrane and suggest key interactions that may stabilize the agonist-induced conformational change.
Facultative protein selenation regulates redox sensitivity, adipose tissue thermogenesis, and obesity
Authors: Jedrychowski Mark P. , Lu Gina Z. , Szpyt John , Mariotti Marco , Garrity Ryan , Paulo Joao A. , Schweppe Devin K. , Laznik-Bogoslavski Dina , Kazak Lawrence , Murphy Michael P. , Gladyshev Vadim N. , Gygi Steven P. , Chouchani Edward T. , Spiegelman Bruce M.
Published: May 2020

Oxidation of cysteine thiols by physiological reactive oxygen species (ROS) initiates thermogenesis in brown and beige adipose tissues. Cellular selenocysteines, where sulfur is replaced with selenium, exhibit enhanced reactivity with ROS. Despite their critical roles in physiology, methods for broad and direct detection of proteogenic selenocysteines are limited. Here we developed a mass spectrometric method to interrogate incorporation of selenium into proteins. Unexpectedly, this approach revealed facultative incorporation of selenium as selenocysteine or selenomethionine into proteins that lack canonical encoding for selenocysteine. Selenium was selectively incorporated into regulatory sites on key metabolic proteins, including as selenocysteine-replacing cysteine at position 253 in uncoupling protein 1 (UCP1). This facultative utilization of selenium was initiated by increasing cellular levels of organic, but not inorganic, forms of selenium. Remarkably, dietary selenium supplementation elevated facultative incorporation into UCP1, elevated energy expenditure through thermogenic adipose tissue, and protected against obesity. Together, these findings reveal the existence of facultative protein selenation, which correlates with impacts on thermogenic adipocyte function and presumably other biological processes as well.
Autophagosome biogenesis: From membrane growth to closure
Authors: Melia Thomas J. , Lystad Alf H. , Simonsen Anne
Published: May 2020

Autophagosome biogenesis involves de novo formation of a membrane that elongates to sequester cytoplasmic cargo and closes to form a double-membrane vesicle (an autophagosome). This process has remained enigmatic since its initial discovery >50 yr ago, but our understanding of the mechanisms involved in autophagosome biogenesis has increased substantially during the last 20 yr. Several key questions do remain open, however, including, What determines the site of autophagosome nucleation? What is the origin and lipid composition of the autophagosome membrane? How is cargo sequestration regulated under nonselective and selective types of autophagy? This review provides key insight into the core molecular mechanisms underlying autophagosome biogenesis, with a specific emphasis on membrane modeling events, and highlights recent conceptual advances in the field.
Wide range of droplet jetting angles by thin-film based surface acoustic waves
Authors: Li Jie , Biroun Mehdi H , Tao Ran , Wang Yong , Torun Hamdi , Xu Na , Rahmati Mohammad , Li Yifan , Gibson Desmond , Fu Chen , Luo Jingting , Dong Linxi , Xie Jin , Fu Yongqing
Published: May 2020

Nozzleless jetting of droplets with different jetting angles is a crucial requirement for 2D and 3D printing/bioprinting applications, and Rayleigh mode surface acoustic waves (SAWs) could be a potential technique for achieving this purpose. Currently, it is critical to vary the jetting angles of liquid droplets induced by SAWs and control the liquid jet directions. Generally, the direction of the liquid jet induced by SAWs generated from a bulk piezoelectric substrate such as LiNbO3 is along the theoretical Rayleigh angle of ∼22°. In this study, we designed and manufactured thin-film SAW devices by depositing ZnO films on different substrates (including silicon and aluminium) to realize a wide range of jetting angles from ∼16° to 55° using propagating waves generated from one interdigital transducer. We then systematically investigated different factors affecting the jetting angles, including liquid properties, applied SAW power and SAW device resonant frequency. Finally, we proposed various methods using thin-film SAW devices together with different transducer designs for realizing a wide range of jetting angles within the 3D domain. A nozzleless jetting method is proposed using thin-film based surface acoustic wave devices to achieve a wide range of jetting angles for droplets.
Flow pressure evaluation on generic surfaces by robotic volumetric PTV
Authors: Jux C , Sciacchitano A , Scarano F
Published: May 2020

An experimental approach for the measurement of the time-average fluid flow pressure over the surface of generic three-dimensional objects is presented. The method is based on robotic volumetric PTV measurements followed by the integration of the pressure gradient. The domain for pressure evaluation is subdivided in two parts: in the irrotational region the static pressure is obtained following Bernoulli relation; in the turbulent wake and close to the object the pressure gradient is integrated. An approach based on the total pressure distribution is proposed to estimate the boundary between these two regions. The method is first assessed with experiments around a sphere equipped with pressure taps. A criterion for minimum spatial resolution is formulated in terms of maximum ratio between bin size and local radius of curvature of the object. An experimental database from a three-dimensional problem of higher geometrical complexity is considered: the time-averaged flow field around a full-scale cyclist. The surface pressure distribution is discussed in connection to the topological features of near-surface streamlines and streamwise vortices.
Comparative characteristics of the fuel and energy balances of Algeria and Russia and directions for improving their structure
Authors: Pulyaeva V N , Kharitonova N A , Messaoudene A
Published: May 2020

This study discovers the problem of stable and reliable functioning of the Algerian and Russian energy and fuel complexes. The analysis of structural changing in the composition of the energy and fuel balances of the countries under consideration allowed the authors of the article to conclude that there is a need for a wider use of secondary energy resources, which requires government support measures aimed at attracting investments and switching to providing own secondary energy resources. The possibilities of Algeria in the development of solar and wind energy are shown. For Russia, the relevance of the wider use of biomass, in particular, wood processing waste, was noted. At the end of the work, the conditions are defined, compliance with which will allow the governments of both countries to carry out the necessary transformation of national fuel and energy complexes.
Potential Scenarios and Hazards in the Work of the Future: A Systematic Review of the Peer-Reviewed and Gray Literatures
Authors: Schulte Paul A , Streit Jessica M K , Sheriff Fatima , Delclos George , Felknor Sarah A , Tamers Sara L , Fendinger Sherry , Grosch James , Sala Robert
Published: May 2020

It would be useful for researchers, practitioners, and decision-makers to anticipate the hazards that workers will face in the future. The focus of this study is a systematic review of published information to identify and characterize scenarios and hazards in the future of work. Eleven bibliographic databases were systematically searched for papers and reports published from 1999 to 2019 that described future of work scenarios or identified future work-related hazards. To compile a comprehensive collection of views of the future, supplemental and ad hoc searches were also performed. After screening all search records against a set of predetermined criteria, the review yielded 36 references (17 peer-reviewed, 4 gray, and 15 supplemental) containing scenarios. In these, the future of work was described along multiple conceptual axes (e.g. labor market changes, societal values, and manual versus cognitive work). Technology was identified as the primary driver of the future of work in most scenarios, and there were divergent views in the literature as to whether technology will create more or fewer jobs than it displaces. Workforce demographics, globalization, climate change, economic conditions, and urbanization were also mentioned as influential factors. Other important themes included human enhancement, social isolation, loneliness, worker monitoring, advanced manufacturing, hazardous exposures, sustainability, biotechnology, and synthetic biology. Pandemics have not been widely considered in the future of work literature, but the recent COVID-19 pandemic illustrates that was short-sighted. Pandemics may accelerate future of work trends and merit critical consideration in scenario development. Many scenarios described ‘new’ or ‘exacerbated’ psychosocial hazards of work, whereas comparatively fewer discussed physical, chemical, or biological hazards. Various preventive recommendations were identified. In particular, reducing stress associated with precarious work and its requirements of continual skill preparation and training was acknowledged as critical for protecting and promoting the health and well-being of the future workforce. In conclusion, the future of work will be comprised of diverse complex scenarios and a mosaic of old and new hazards. These findings may serve as the basis for considering how to shape the future of work.
Tacit knowledge, cultural values and agential possibility in rural Haiti
Authors: Stephenson Max , Zanotti Laura
Published: May 2020

This article recounts the efforts of a group of subsistence farmers (earning approximately $1.00 per day in income) in a mountainous rural part of Haiti who, working with a young social entrepreneur from their community, have self-organized to develop more economic opportunities by improving their farming practices communally. We posit that they have done so on the basis of the Haitian value of konbit, a form of social sharing and solidarity, and thus, on a foundation of what Michael Polanyi has termed tacit knowledge of their situational context. We suggest that efforts to secure development be rooted in initiatives aimed at catalyzing residents’ self-mobilization capacities and tacit communal knowledge and values, even if, or when, such an approach requires more time or resources to obtain desired outcomes. We also highlight critical perspectives of the now ubiquitous concept of resilience to explore the possibilities and limitations of agency that emerge from tacit knowledge in the context of continuing neoliberalism and its accompanying structural violence. We conclude that Polanyi’s ideas of freedom and agency provide a much more robust foundation on which to build a conceptualization of development and political–economic change than is offered by today’s prevailing neoliberal ‘resilience’ imaginary.
Brain Wiring and Supragranular-Enriched Genes Linked to Protracted Human Frontal Cortex Development
Authors: Hendy Jasmine P , Takahashi Emi , van der Kouwe Andre J , Charvet Christine J
Published: May 2020

The human frontal cortex is unusually large compared with many other species. The expansion of the human frontal cortex is accompanied by both connectivity and transcriptional changes. Yet, the developmental origins generating variation in frontal cortex circuitry across species remain unresolved. Nineteen genes that encode filaments, synapse, and voltage-gated channels are especially enriched in the supragranular layers of the human cerebral cortex, which suggests enhanced corticocortical projections emerging from layer III. We identify species differences in connections with the use of diffusion MR tractography as well as gene expression in adulthood and in development to identify developmental mechanisms generating variation in frontal cortical circuitry. We demonstrate that increased expression of supragranular-enriched genes in frontal cortex layer III is concomitant with an expansion in corticocortical pathways projecting within the frontal cortex in humans relative to mice. We also demonstrate that the growth of the frontal cortex white matter and transcriptional profiles of supragranular-enriched genes are protracted in humans relative to mice. The expansion of projections emerging from the human frontal cortex arises by extending frontal cortical circuitry development. Integrating gene expression with neuroimaging level phenotypes is an effective strategy to assess deviations in developmental programs leading to species differences in connections.
Risk Factors Associated With Clinical Outcomes in 323 Coronavirus Disease 2019 (COVID-19) Hospitalized Patients in Wuhan, China
Authors: Hu Ling , Chen Shaoqiu , Fu Yuanyuan , Gao Zitong , Long Hui , Ren Hong-wei , Zuo Yi , Wang Jie , Li Huan , Xu Qing-bang , Yu Wen-xiong , Liu Jia , Shao Chen , Hao Jun-jie , Wang Chuan-zhen , Ma Yao , Wang Zhanwei , Yanagihara Richard , Deng Youping
Published: May 2020

Background

With evidence of sustained transmission in more than 190 countries, coronavirus disease 2019 (COVID-19) has been declared a global pandemic. Data are urgently needed about risk factors associated with clinical outcomes.

Methods

A retrospective review of 323 hospitalized patients with COVID-19 in Wuhan was conducted. Patients were classified into 3 disease severity groups (nonsevere, severe, and critical), based on initial clinical presentation. Clinical outcomes were designated as favorable and unfavorable, based on disease progression and response to treatments. Logistic regression models were performed to identify risk factors associated with clinical outcomes, and log-rank test was conducted for the association with clinical progression.

Results

Current standard treatments did not show significant improvement in patient outcomes. By univariate logistic regression analysis, 27 risk factors were significantly associated with clinical outcomes. Multivariate regression indicated age >65 years (P < .001), smoking (P = .001), critical disease status (P = .002), diabetes (P = .025), high hypersensitive troponin I (>0.04 pg/mL, P = .02), leukocytosis (>10 × 109/L, P < .001), and neutrophilia (>75 × 109/L, P < .001) predicted unfavorable clinical outcomes. In contrast, the administration of hypnotics was significantly associated with favorable outcomes (P < .001), which was confirmed by survival analysis.

Conclusions

Hypnotics may be an effective ancillary treatment for COVID-19. We also found novel risk factors, such as higher hypersensitive troponin I, predicted poor clinical outcomes. Overall, our study provides useful data to guide early clinical decision making to reduce mortality and improve clinical outcomes of COVID-19.
Use of the Endoscopic Healing Index for Monitoring of Disease Activity in Patients With Crohn’s Disease in the COVID Era
Authors: Abreu Maria T , Okada Lauren , Dervieux Thierry , Luo Allison , Jain Anjali , Ritter Timothy , Hanauer Stephen B
Published: May 2020

Lay Summary

Management of Crohn’s disease (CD) during COVID-19 is challenging when colonoscopy is not feasible. This study describes a blood-based test that has been validated against colonoscopy in patients with CD as an alternative even in patients with high inflammation from infections.
The Days of Wine and Roses
Authors: Klabbers Jan
Published: May 2020

This review essay takes an in-depth look at the most recent addition to the Oppenheim family, a two-volume work on the law and practice of the United Nations, prepared by Rosalyn Higgins and a dream team composed of some of her former students. The essay not only zooms in on the merits of the work but also aims to place it in context in a changing world, wistfully noting a little nostalgia (on the side of the reviewer as well as that of the authors perhaps) for, well, the days of wine and roses.
Plastid Genome Evolution in the Subtribe Calypsoinae (Epidendroideae, Orchidaceae)
Authors: Li Zhang-Hai , Jiang Yan , Ma Xiao , Li Jian-Wu , Yang Jun-Bo , Wu Jian-Yong , Jin Xiao-Hua
Published: May 2020

Calypsoinae is a small subtribe in Orchidaceae (Epidendroideae) characterized by diverse trophic strategies and morphological characters. Calypsoinae includes 13 genera, four of which are leafless and mycoheterotrophic. Mycoheterotrophic species in the leafless genus Corallorhiza are well suited to studies of plastome evolution. However, the lack of plastome sequences for other genera in Calypsoinae limits the scope of comparative and phylogenetic analyses, in particular our understanding of plastome evolution. To understand plastid genome evolution in Calypsoinae, we newly sequenced the plastomes of 12 species in the subtribe, including representatives of three mycoheterotrophic genera as well as five autotrophic genera. We detected two parallel photosynthetic losses in Corallorhiza. Evolutionary analyses indicated that the transition to obligate mycoheterotrophy leads to the relaxation of selection in a highly gene-specific pattern.
A Local Limit Theorem and Delocalization of Eigenvectors for Polynomials in Two Matrices
Authors: Ho Ching-Wei
Published: May 2020

We propose a boundary regularity condition for the $M_n({\mathbb{C}})$-valued subordination functions in free probability to prove a local limit theorem and delocalization of eigenvectors for self-adjoint polynomials in two random matrices. We prove this through estimating the pair of $M_n({\mathbb{C}})$-valued approximate subordination functions for the sum of two $M_n({\mathbb{C}})$-valued random matrices $\gamma _1\otimes C_N+\gamma _2\otimes U_N^*D_NU_N$, where $C_N$, $D_N$ are deterministic diagonal matrices, and $U_N$ is Haar unitary.
In vitro dynamics and mechanisms of resistance development to imipenem and imipenem/relebactam in Pseudomonas aeruginosa
Authors: Gomis-Font María A , Cabot Gabriel , Sánchez-Diener Irina , Fraile-Ribot Pablo A , Juan Carlos , Moya Bartolome , Zamorano Laura , Oliver Antonio
Published: May 2020

Objectives

We analysed the dynamics and mechanisms of resistance development to imipenem alone or combined with relebactam in Pseudomonas aeruginosa WT (PAO1) and mutator (PAOMS; ΔmutS) strains.

Methods

PAO1 or PAOMS strains were incubated for 24 h in Mueller–Hinton Broth with 0.125–64 mg/L of imipenem ± relebactam 4 mg/L. Tubes from the highest antibiotic concentration showing growth were reinoculated in fresh medium containing concentrations up to 64 mg/L of imipenem ± relebactam for 7 days. Two colonies per strain, replicate experiment and antibiotic from early (Day 1) and late (Day 7) cultures were characterized by determining the susceptibility profiles, WGS and determination of the expression of ampC and efflux-pump-coding genes. Virulence was studied in a Caenorhabditis elegans infection model.

Results

Relebactam reduced imipenem resistance development for both strains, although resistance emerged much faster for PAOMS. WGS indicated that imipenem resistance was associated with mutations in the porin OprD and regulators of ampC, while the mutations in imipenem/relebactam-resistant mutants were located in oprD and regulatoras of MexAB-OprM. High-level imipenem/relebactam resistance was only documented in the PAOMS strain and was associated with an additional specific (T680A) mutation located in the catalytic pocket of ponA (PBP1a) and with reduced virulence in the C. elegans model.

Conclusions

Imipenem/relebactam could be a useful alternative for the treatment of MDR P. aeruginosa infections, potentially reducing resistance development during treatment. Moreover, this work deciphers the potential resistance mechanisms that may emerge upon the introduction of this novel combination into clinical practice.
Reconstruction of Severe Burns to the Breast in Pediatric Patients: A 10-Year Experience
Authors: Sadeq Farzin , Cauley Ryan , Depamphilis Matthew A , Driscoll Daniel N , Ehrlichman Richard
Published: May 2020

The breast and anterior chest are the most commonly burned part of the trunk. Burn injuries to the breast can be associated with pain, asymmetries, and significant social stigma. Burns to the breast bud in the young female may inhibit normal breast development and result in either significant asymmetries or amastia, making the treatment of breast burn injuries challenging. A retrospective chart review was conducted on all female patients under the age of 21 years admitted to our institution for breast burn injuries from January 1, 2008 to December 30, 2018. Patients were included if they had follow-up reconstructive procedures for breast burn injuries many days after their acute-phase treatment. Ninety-six patients aged 1 to 20 years have been admitted to our institution with burned breast injuries. The mean age of this cohort (n = 96) was 6.4 ± 4.8 years with a mean percent TBSA of 36.3 ± 21.4 and a mean time since injury from admission of 2279.1 ± 2284.1 days. Flame burns (66.8 percent) were the most common etiology for breast burn injuries, followed by scald burns (22.8 percent), in this cohort. The mean body mass index was 22.7 ± 6.3 kg/m2. Follow-up for reconstructive procedures was 7.2 ± 5.6 years after injury date. Our institution’s 10-year experience of 96 female patients with severe burn injuries has enhanced our understanding of reconstructive techniques. The location, size, anatomic extent, type of deformity, and symmetry must all be assessed before any treatment plans, which may need to include a combination of modalities.
Interdependence of Narrative Characters: Implications for Media Theories
Authors: Grizzard Matthew , Francemone C Joseph , Fitzgerald Kaitlin , Huang Jialing , Ahn Changhyun
Published: May 2020

Affective disposition theory suggests that viewers of narratives develop dispositions toward characters through various cues, including appearance and behavior. Despite its predictive utility, the theory has yet to account for an essential component of narratives: character interdependence. Extant models treat disposition formation toward individual characters as an independent process. In the current paper, we posit that affective dispositions formed toward one character (e.g., a protagonist) are interdependent with affective dispositions formed toward others (e.g., an antagonist). We present two experimental studies that provide evidence of character interdependence. We show that dispositions toward a single character account for unique variance in dispositions toward another, and that the same character can be perceived as highly moral or immoral, depending on a comparison character. In the discussion section, we integrate our character interdependence model with extant theories to generate novel predictions for affective disposition theory and other areas of research relevant to communication.
Role of magnetically dominated disc-outflow symbiosis on bright hard-state black hole sources: ultra-luminous X-ray sources to quasars
Authors: Mondal Tushar , Mukhopadhyay Banibrata
Published: May 2020

We present optically thin solutions for magnetized, advective disc-outflow symbiosis around black holes (BHs). The main objective is to explain the bright, hard-state observations of accreting systems with stellar mass-to-supermassive BHs. We include the effects of magnetic fields and radiation counterpart in entropy gradient based on the first law of thermodynamics to represent energy advection. The cooling process includes bremsstrahlung, synchrotron radiation, and inverse Comptonization process. One of our main ventures is to explain some long-standing issues of ultra-luminous X-ray sources (ULXs). The existing physical scenarios to explain their unusual high luminosity are either the existence of the missing class of intermediate-mass BH (IMBH) or super-Eddington accretion around a stellar-mass BH. However, most ULXs with steep power-law spectrum can be well explained through super-Eddington accretion, while the existence of IMBH is indeed disputed extensively. Nevertheless, the interpretation of ULXs with a hard power-law-dominated state remains mysterious. Here we show that our magnetically dominated disc-outflow symbiosis around rapidly spinning stellar-mass BHs can achieve such large luminosity even for sub-Eddington accretion rate. The magnetic field at the outer zone of the advective flow is more than the corresponding Eddington limit. Such a field becomes dynamically dominant near the BH through continuous accretion process due to flux freezing, but maintaining its Eddington limit. This unique field configuration enhances the synchrotron and synchrotron self-Comptonization process to achieve very large luminosity. Through the same mechanism, our solutions for supermassive BHs can explain the unusual large luminosity of ultra-luminous quasars.
Improving galaxy clustering measurements with deep learning: analysis of the DECaLS DR7 data
Authors: Rezaie Mehdi , Seo Hee-Jong , Ross Ashley J , Bunescu Razvan C
Published: May 2020

Robust measurements of cosmological parameters from galaxy surveys rely on our understanding of systematic effects that impact the observed galaxy density field. In this paper, we present, validate, and implement the idea of adopting the systematics mitigation method of artificial neural networks for modelling the relationship between the target galaxy density field and various observational realities including but not limited to Galactic extinction, seeing, and stellar density. Our method by construction allows a wide class of models and alleviates overtraining by performing k-fold cross-validation and dimensionality reduction via backward feature elimination. By permuting the choice of the training, validation, and test sets, we construct a selection mask for the entire footprint. We apply our method on the extended Baryon Oscillation Spectroscopic Survey (eBOSS) Emission Line Galaxies (ELGs) selection from the Dark Energy Camera Legacy Survey (DECaLS) Data Release 7 and show that the spurious large-scale contamination due to imaging systematics can be significantly reduced by up-weighting the observed galaxy density using the selection mask from the neural network and that our method is more effective than the conventional linear and quadratic polynomial functions. We perform extensive analyses on simulated mock data sets with and without systematic effects. Our analyses indicate that our methodology is more robust to overfitting compared to the conventional methods. This method can be utilized in the catalogue generation of future spectroscopic galaxy surveys such as eBOSS and Dark Energy Spectroscopic Instrument (DESI) to better mitigate observational systematics.
Ancient Hybridization with an Unknown Population Facilitated High-Altitude Adaptation of Canids
Authors: Wang Ming-Shan , Wang Sheng , Li Yan , Jhala Yadvendradev , Thakur Mukesh , Otecko Newton O , Si Jing-Fang , Chen Hong-Man , Shapiro Beth , Nielsen Rasmus , Zhang Ya-Ping , Wu Dong-Dong
Published: May 2020

Genetic introgression not only provides material for adaptive evolution but also confounds our understanding of evolutionary history. This is particularly true for canids, a species complex in which genome sequencing and analysis has revealed a complex history of admixture and introgression. Here, we sequence 19 new whole genomes from high-altitude Tibetan and Himalayan wolves and dogs and combine these into a larger data set of 166 whole canid genomes. Using these data, we explore the evolutionary history and adaptation of these and other canid lineages. We find that Tibetan and Himalayan wolves are closely related to each other, and that ∼39% of their nuclear genome is derived from an as-yet-unrecognized wolf-like lineage that is deeply diverged from living Holarctic wolves and dogs. The EPAS1 haplotype, which is present at high frequencies in Tibetan dog breeds and wolves and confers an adaptive advantage to animals living at high altitudes, was probably derived from this ancient lineage. Our study underscores the complexity of canid evolution and demonstrates how admixture and introgression can shape the evolutionary trajectories of species.