bluuebunny/crossref_metadata_2025 huggingface dataset:
Acute Aortic Dissection during Pregnancy: Hideous Clinical Quandaries with Young Lives on the Line—The Role of Hereditary Genetic Syndromes
Authors: Haunschild Josephina , Wiktorowska Paulina , Eifert Sandra , Stepan Holger , Dähnert Ingo , Borger Michael A. , Etz Christian D.
Published: August 2024

Objective: Acute aortic dissection is a rare but frequently fatal aortic catastrophe with high morbidity and mortality. Especially in pregnant patients, acute dissection is often misdiagnosed putting two lives on the line. Due to its scarcity, only case reports have been reported. The aim of this study is to analyze the time of aortic dissection during the course of pregnancy and the outcome of emergency surgery in pregnant women with and without hereditary connective tissue disorder. Methods: We retrospectively reviewed all acute aortic dissections (type A and B) who underwent emergency aortic surgery at our institution between 1994 and 2022 and identified 13 patients with acute aortic dissection during pregnancy or directly postpartum. Mann–Whitney U and Fisher’s exact tests were used for statistical analysis. Results: Of the 13 included patients, 5 had a genetic syndrome. These patients were significantly younger at the time of dissection and at an earlier stage of pregnancy (second trimester). Even though operative and in-house mortality was zero, we lost one patient on postoperative day 14 due to rupture of the aortic root after transfer to another hospital. Survival of neonates was 77% including two aborted pregnancies. Conclusions: Surgical treatment of acute aortic dissection during pregnancy can be performed with excellent operative mortality for the mothers and satisfying survival of their neonates. In patients with genetic syndrome, dissection occurs during the early second trimester, whereas non-syndromic patients experience acute dissection in the late third trimester. Long-term follow-up is essential for timely re-intervention, if needed.
Differential Ophthalmological Profile in Patients with Coronary Artery Disease Coexisting with Type 2 Diabetes Mellitus: Elevated Tear Cytokine Concentrations
Authors: Jiménez-López Rafael , Romero-Trevejo José Lorenzo , Fernández-Romero Lourdes , Martín-Chaves Laura , Romero-Cuevas Miguel , Molina-Ramos Ana Isabel , Sánchez-Quintero María José , Murri Mora , Costa Francesco , Bodí Vicente , Gutiérrez-Bedmar Mario , Rodríguez-Capitán Jorge , Pavón-Morón Francisco Javier , Jiménez-Navarro Manuel
Published: August 2024

Background/Objectives: Coronary artery disease (CAD) and type-2 diabetes mellitus (T2DM) are characterized by chronic low-grade inflammation. However, measuring cytokines typically involves invasive blood sampling, which can be problematic for CAD patients. This study aimed to assess ophthalmological parameters and tear cytokines in patients with CAD, comparing those with comorbid T2DM to those without to understand their inflammatory profiles. Methods: One hundred subjects with suspected chronic or acute CAD were initially included in this single-center cross-sectional study after clinical stabilization. Seventy-two patients with confirmed CAD were divided into two groups: 32 patients with T2DM and 40 patients without T2DM. A total of 144 eyes were examined, and tear fluid samples were collected to determine cytokine concentrations. Ophthalmological parameters and tear concentrations of cytokines were analyzed, controlling for age, sex, and other cardiovascular risk factors. Results: Patients with CAD and T2DM exhibited decreased ophthalmological parameters and increased cytokine concentrations in comparison to those without T2DM. Significant inverse correlations between ophthalmological parameters and cytokine concentrations were observed. Following adjustment, a full logistic regression model for distinguishing patients with CAD and comorbid T2DM included macular cube volume, mean macular thickness, interleukin (IL)-4, IL-5, IL-6, IL-8, IL-9, IL-13, granulocyte colony-stimulating factor (G-CSF), CCL3, CCL4, and CCL11/eotaxin-1, demonstrating excellent discriminatory power (Area Under the Curve = 0.95, 95% Confidence Interval = 0.91–0.99; p < 0.001). Subsequently, IL-5 (Odds Ratio = 1.68, 95% CI = 1.26–2.24; p < 0.001), G-CSF (OR = 1.06, 95% CI = 1.02–1.11; p < 0.01), and CCL11/eotaxin-1 (OR = 1.56, 95% CI = 1.19–2.05; p = 0.001) emerged as the most distinguishing variables in a reduced model (AUC = 0.89, 95% CI = 0.84–0.95; p < 0.001). Conclusions: Differences in ophthalmological variables, mainly in cytokine concentrations, suggest distinct pathophysiological mechanisms in patients with CAD based on the presence of T2DM. These findings demonstrate that the inflammatory profile can be readily detected through tear sample cytokines, proving valuable for establishing more accurate prognoses and monitoring in cardiometabolic disorders.
Intravascular Lithotripsy: Approach to Advanced Calcified Coronary Artery Lesions, Current Understanding, and What Could Possibly Be Studied Next
Authors: Kochiashvili Giorgi , Fongrat Natalia , Baraskar Bhavana , Amare Biruk , Iantorno Micaela
Published: August 2024

Calcified and resistant narrowing of arteries poses significant difficulty in performing percutaneous coronary interventions (PCIs), as they increase the risk of subpar outcomes leading to worse clinical outcomes. Despite the existence of dedicated technologies and devices, including various balloons and atherectomy systems, they often do not ensure sufficient plaque modification and ideal vessel preparation for optimal stent deployment. Intravascular lithotripsy (IVL), a technology originally developed for urological procedures, has recently been used to safely and selectively disrupt calcified depositions in both peripheral and coronary arteries by sonic waves that seamlessly transfer to nearby tissue, enhancing vessel compliance with minimal impact on soft tissues. In the coronary arteries, the use of IVL plays a role in the process of “vessel preparation” before the placement of stents, which is crucial for restoring blood flow in patients with severe coronary artery disease (CAD), and is considered a minimally invasive technique, reducing the need for open heart surgeries and associated risks and complications. Studies have shown that IVL can lead to improved procedural success rates and favorable long-term outcomes for patients with severely calcified coronary artery disease. With the advent of IVL, the disruption of severe calcification of coronary artery and stenotic lesions before stent implantations can be performed. Despite promising data for treating calcified lesions, IVL is significantly underutilized in clinical practice, long-term clinical data and extensive research are needed to validate its further safety and efficacy. In this article, we reviewed the literature discussing the use of IVL in the coronary arteries as an approach for addressing intravascular atherosclerotic plaques, particularly focusing on heavily calcified plaques that are resistant to standard initial PCI, while also evaluating its safety in comparison to alternative methods.
Association of Malocclusion with Temporomandibular Disorders: A Cross-Sectional Study
Authors: Ângelo David Faustino , Faria-Teixeira Maria Cristina , Maffia Francesco , Sanz David , Sarkis Marcella , Marques Rute , Mota Beatriz , João Ricardo São , Cardoso Henrique José
Published: August 2024

Background/Objectives: Temporomandibular disorders (TMD) encompass a range of musculoskeletal and neuromuscular conditions affecting the temporomandibular joint (TMJ) and associated structures. This cross-sectional study, conducted in a Portuguese TMD department, aimed to assess the relationship between malocclusion and TMD severity. Methods: Data on demographic variables, TMD clinical symptoms, and malocclusion classes were collected using the EUROTMJ database. The Chi-square test (χ2) identified associations, with their intensity measured by Cramér’s V (φc). Results: The study included 1170 patients (932 females and 238 males), with a mean age of 41.73 ± 16.80 years. Most patients exhibited Angle Class I malocclusion (85.5%), followed by Angle Class II (13.5%) and Angle Class III (1.1%). Class II malocclusion was associated with increased TMD severity (p < 0.001), higher myalgia levels (p = 0.002), more frequent disc displacement without reduction (p = 0.002) and lower maximum mouth opening values (Class II: 38.13 ± 7.78 mm, Class I: 39.93 ± 8.67 mm). Significant associations were also found between malocclusion type and arthralgia (p = 0.021), mouth-opening limitation (p = 0.016), and TMJ crepitus (p = 0.017). In cases of malocclusion, the presence of oral signs of bruxism explained the degree of myalgia, disc displacement, and severity (p = 0.003; p = 0.048; p = 0.045). Conclusions: This study highlights that (1) the most common type of dental malocclusion in TMD patients was Class I; (2) Class II malocclusion was associated with increased TMD severity and oral signs of bruxism; and (3) Class III was rarely observed in TMD consultation. The findings suggest that bruxism behavior in cases of malocclusion may be significant in TMD.
Lateral Spinal Artery Aneurysm Causing Subarachnoid Hemorrhage: Literature Review and Case Report
Authors: Jeon Yoo Sung , Park Jeong Jin , Chun Young Il , Roh Hong Gee
Published: August 2024

Ruptured aneurysms of the lateral spinal artery (LSA) causing subarachnoid hemorrhage (SAH) are exceptionally rare. Unlike common aneurysms in the circle of Willis, LSA aneurysms present unique diagnostic and therapeutic challenges due to their complex anatomy. We reviewed the literature, examining case reports detailing LSA aneurysm occurrences, diagnoses, treatments, and complications, and our subsequent analysis highlights the clinical presentations, imaging findings, treatment methods, and anatomical features of the LSA. We identified 10 patients from 7 case reports of LSA aneurysm presenting with SAH, and combined with the present case, this comprised a total of 11 patients. An initial CT angiography identified LSA aneurysm in only 2 of 11 patients, while 5 cases were detected in transfemoral cerebral angiography. Seven patients had stenosis or occlusion of nearby arteries. Among the 10 patients treated, 7 underwent microsurgical clipping, and 3 had endovascular treatment; complications included PICA infarction and subdural hematoma. LSA aneurysms, though rare, should be considered in differential diagnoses of posterior fossa SAH. An accurate diagnosis often requires repeated imaging. It is proposed to individualize treatment strategies based on the unique anatomical structure and hemodynamic conditions of each patient, utilizing both endovascular and surgical approaches. Understanding the vascular anatomy and collateral pathways of the LSA is crucial for improving diagnostic accuracy and treatment outcomes.
Left Ventricular Deformation and Myocardial Work Parameters in Patients with Hereditary Transthyretin Amyloidosis Treated with Patisiran: A Single-Center Study
Authors: Di Lisi Daniela , Comparato Francesco , Ortello Antonella , Di Stefano Vincenzo , Brighina Filippo , Macaione Francesca , La Fiura Giovanni , Di Caccamo Leandro , Madaudo Cristina , Galassi Alfredo R. , Novo Giuseppina
Published: August 2024

Background: In recent years, many advances have been made in the treatment of hereditary transthyretin amyloidosis (ATTRv). Patisiran is a small-interfering RNA used to treat ATTRv with only polyneuropathy or polyneuropathy and cardiomyopathy. The aim of our study was to assess the effect of patisiran on cardiac function in ATTRv patients using speckle tracking echocardiography (STE) analysis. Methods: A single-center prospective study was performed enrolling 21 patients with ATTRv (11 M—52% of the population; 10 F—48% of the population; median age 66 ± 8.4 years old). A total of 7 patients had cardiac amyloidosis and polyneuropathy, and 14 patients had only polyneuropathy without cardiac involvement. Cardiological evaluation including electrocardiograms, echocardiography with STE, and assessment of myocardial work parameters was performed in all patients before starting patisiran and after 9–18 months. Functional capacity was assessed using the 6 min walk test; quality of life was assessed using the Kansas City Cardiomyopathy Questionnaire (KCCQ). Results: We did not find a significant difference in gender prevalence of ATTR amyloidosis in all of the population (p-value 0.79), but we found that cardiac amyloidosis significantly predominated in the male sex compared to patients with only neuropathy. In all patients, we found a slight improvement in functional capacity and quality of life. We did not find significant changes in left ventricular ejection fraction (LVEF), but we found a significant improvement in left ventricular global longitudinal strain (GLS), global work waste (GWW), and global work efficiency (GWE), especially in patients with cardiac amyloidosis; E/e’ average and left atrial stiffness also improved significantly in patients with cardiac amyloidosis. Conclusions: Our study confirms a positive effect of patisiran on cardiac function, particularly the absence of signs of subclinical deterioration as detected by very sensitive STE parameters such as GLS, MW, and atrial stiffness during follow up in patients treated with patisiran.
Individual Differences in Psychological Stress Associated with Data Breach Experiences
Authors: Sears Christopher R. , Cunningham Daniel R.
Published: August 2024

Data breach incidents are now a regular occurrence, with millions of people affected worldwide. Few studies have examined the psychological aspects of data breach experiences, however, or the individual differences that influence how people react to these events. In this study, we examined the psychological stress associated with a personal experience with a data breach and several individual differences hypothesized to modulate such stress (age, gender, digital security awareness and expertise, trait anxiety, negative emotionality, and propensity to worry). A student sample (N = 166) and a community sample (N = 359) completed an online survey that asked participants to describe their most serious data breach and then complete the Impact of Events Scale—Revised (IES-R) to answer specific questions about the nature of the stress they experienced after the breach. Standard measures of trait anxiety, negative emotionality, and propensity to worry were also completed. A Data Breach Severity Index (DBSI) was created to quantify the invasiveness and consequences of each participant’s data breach. Hierarchical multiple regression analyses were used to identify demographic variables and psychological characteristics predictive of IES-R scores while controlling for DBSI scores. As expected, more invasive and consequential data breaches were associated with higher IES-R scores (greater data-breach-induced stress). Women had higher IES-R scores than men, and this difference persisted after controlling for gender differences in anxiety, negative emotionality, and propensity to worry. Greater daily social media use was associated with higher IES-R scores, whereas higher digital security expertise was associated with lower IES-R scores. The results illuminate several relationships between demographic and psychological characteristics and data-breach-induced stress that should be investigated further.
Cell Proliferation, Chondrogenic Differentiation, and Cartilaginous Tissue Formation in Recombinant Silk Fibroin with Basic Fibroblast Growth Factor Binding Peptide
Authors: Yamada Manabu , Nakajima Arata , Sakurai Kayo , Tamada Yasushi , Nakagawa Koichi
Published: August 2024

Regeneration of articular cartilage remains a challenge for patients who have undergone cartilage injury, osteochondritis dissecans and osteoarthritis. Here, we describe a new recombinant silk fibroin with basic fibroblast growth factor (bFGF) binding peptide, which has a genetically introduced sequence PLLQATLGGGS, named P7. In this study, we cultured a human mesenchymal cell line derived from bone marrow, UE6E7-16, in wild-type fibroin sponge (FS) and recombinant silk fibroin sponge with P7 peptide (P7 FS). We compared cell proliferation, chondrogenic differentiation and cartilaginous tissue formation between the two types of sponge. After stimulation with bFGF at 3 ng/mL, P7 FS showed significantly higher cell growth (1.2-fold) and higher cellular DNA content (5.6-fold) than did wild-type FS. To promote chondrogenic differentiation, cells were cultured in the presence of TGF-β at 10 ng/mL for 28 days. Immunostaining of P7 FS showed SOX9-positive cells comparable to wild-type FS. Alcian-Blue staining of P7 FS also showed cartilaginous tissue formation equivalent to wild-type FS. A significant increase in cell proliferation in P7 FS implies future clinical application of this transgenic fibroin for regeneration of articular cartilage. To produce cartilaginous tissue efficiently, transgenic fibroin sponges and culture conditions must be improved. Such changes should include the selection of growth factors involved in chondrogenic differentiation and cartilage formation.
An Evaluation of the Cytocompatibility of Endodontic Bioceramics in Human Periodontal-Ligament-Derived Cells
Authors: Aka Asuka , Matsuura Takashi , Yoshimura Atsutoshi
Published: August 2024

The present study evaluated the cytocompatibility of three endodontic bioceramics in human periodontal-ligament-derived cells (hPDLCs): MTA Repair HP (HP), MTA Flow White (F), and Nishika Canal Sealer BG multi (BG). In addition, we also evaluated the effect of the powder–liquid (paste) ratio of F and BG on cytocompatibility. Discs of endodontic bioceramics (diameter = 8 mm, thickness = 1 mm) were prepared with HP, F, and BG. hPDLCs obtained from extracted teeth and cultured for three to five passages were used in the experiment. The prepared discs were placed at the bottom of a 48-well plate, seeded with hPDLCs at 100,000 cells/well, cultured for 7 or 28 days, and subjected to a 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide assay. hPDLCs cultured without any discs were used as a negative control (NC) group. Discs made of F or BG mixed in three different consistencies were also used in this experiment. The absorbance values at days 7 and 28 were high in the order of HP > NC > BG > F. Furthermore, F or BG with higher consistency showed higher absorbance values. MTA Repair HP had the highest cytocompatibility among the three materials. Furthermore, it also showed that higher consistency improved cytocompatibility.
Biomaterial Scaffolds for Periodontal Tissue Engineering
Authors: Chen Huanhuan , Song Guangying , Xu Tianmin , Meng Chenda , Zhang Yunfan , Xin Tianyi , Yu Tingting , Lin Yifan , Han Bing
Published: August 2024

Advanced periodontitis poses a significant threat to oral health, causing extensive damage and loss of both hard and soft periodontal tissues. While traditional therapies such as scaling and root planing can effectively halt the disease’s progression, they often fail to fully restore the original architecture and function of periodontal tissues due to the limited capacity for spontaneous regeneration. To address this challenge, periodontal tissue engineering has emerged as a promising approach. This technology centers on the utilization of biomaterial scaffolds, which function as three-dimensional (3D) templates or frameworks, supporting and guiding the regeneration of periodontal tissues, including the periodontal ligament, cementum, alveolar bone, and gingival tissue. These scaffolds mimic the extracellular matrix (ECM) of native periodontal tissues, aiming to foster cell attachment, proliferation, differentiation, and, ultimately, the formation of new, functional periodontal structures. Despite the inherent challenges associated with preclinical testing, the intensification of research on biomaterial scaffolds, coupled with the continuous advancement of fabrication technology, leads us to anticipate a significant expansion in their application for periodontal tissue regeneration. This review comprehensively covers the recent advancements in biomaterial scaffolds engineered specifically for periodontal tissue regeneration, aiming to provide insights into the current state of the field and potential directions for future research.
Effects of Oral Lactate Supplementation on Acid–Base Balance and Prolonged High-Intensity Interval Cycling Performance
Authors: Bordoli Claire , Varley Ian , Sharpe Graham R. , Johnson Michael A. , Hennis Philip J.
Published: August 2024

Lactate is an important energy intermediate and metabolic buffer, and may be ergogenic. We investigated if lactate supplementation is an effective approach to enhance the exercise performance and acid–base balance of trained cyclists during exercise devised to simulate the demands of endurance road race cycling. Sixteen endurance-trained male cyclists (V·O2max 59 ± 7 mL·kg−1·min−1) consumed 120 mg·kg−1 body mass of lactate or a placebo 70 min prior to performing an exercise performance test, comprising five repeated blocks consisting of 1 km and 4 km time trials interspersed with 10 min of moderate-intensity exercise. Blood acid–base balance (including [H+] and [HCO3−]), heart rate, perceived exertion, and gastro-intestinal tolerance were assessed. There was no effect of lactate supplementation on exercise performance (p = 0.320), despite a reduction in RPE (p = 0.012) and increases in [SID] (p = 0.026) and [HCO3−] (p = 0.041). In addition, gastro-intestinal side effects were observed, but there was no effect on heart rate. Lactate supplementation did not improve exercise performance, despite positive changes in acid–base balance and RPE. This suggests that the alkalising effects of the supplement can reduce perceived effort, but these benefits do not translate into performance improvements.
Spatial Patterns and Evolution Features of Marine Cold Spells in the Arabian Sea during the Past Three Decades
Authors: Wang Qianqian , Zhang Zhihua , Crabbe M. James C.
Published: August 2024

Marine Cold Spell (MCS) events are cold sea states with potentially devastating impacts on marine environments and ecosystems. In this study, we analyzed different MCS types with various severe categories in the Arabian Sea during 1994–2023. We found that all four types of MCS events shared a similar spatial pattern in terms of frequency, mean duration, mean intensity, and total days, but the frequency of 1-MCS events had a sharply decreasing trend compared with any other type of MCS events, indicating that ocean warming mainly led to the significant disappearance of short-period MCS events. Moreover, the MCS events in offshore Somalia had the highest occurring frequency, longest duration, largest intensity, and maximal total days, and were significantly different from those in other regions of the Arabian Sea. This is originated from that the cold–warm changes of the Somali current make larger fluctuations in the sea surface temperatures of the waters off Somalia, enhancing the occurring probability of MCS events, especially during the summers.
The Effects of Assumed AI vs. Human Authorship on the Perception of a GPT-Generated Text
Authors: Lermann Henestrosa Angelica , Kimmerle Joachim
Published: August 2024

Artificial Intelligence (AI) has demonstrated its ability to undertake writing tasks, including automated journalism. Prior studies suggest no differences between human and AI authors regarding perceived message credibility. However, research on people’s perceptions of AI authorship on complex topics is lacking. In a between-groups experiment (N = 734), we examined the effect of labeled authorship on credibility perceptions of a GPT-written science journalism article. The results of an equivalence test showed that labeling a text as AI-written vs. human-written reduced perceived message credibility (d = 0.36). Moreover, AI authorship decreased perceived source credibility (d = 0.24), anthropomorphism (d = 0.67), and intelligence (d = 0.41). The findings are discussed against the backdrop of a growing availability of AI-generated content and a greater awareness of AI authorship.
Spatiotemporal Variations in Fingerprinting Sediment Sources in a Watershed Disturbed by Construction
Authors: Zhu Baicheng , Cao Longxi , Yang Sen , Pan Heping , Liu Fei , Kong Yaping
Published: August 2024

Engineering construction disturbs the Earth’s surface and exacerbates soil erosion, resulting in sediment contributions at the watershed scale, the spatiotemporal variation of which remains to be clarified. Based on a typically disturbed catchment, soil samples were collected from sources such as forests, grasslands, spoil heaps, and exposed slopes. Sediment deposition was sampled in 2022 and 2023 along the main channel and fingerprinting technology was employed to calculate the relative contributions of different sources. The results indicated that the optimal composite fingerprints comprising Na₂O, Li, Sr, and Ce could effectively resolve the contributions of different sources. Natural sources were the main sediment contributors, but the average contribution decreased from 72.96% to 58.73% over two periods. In contrast, the contribution of spoil heaps and exposed slopes increased from 27.04% to 41.27% and the area percentage increased from 0.18% to 0.30%. The spoil heap represents the relatively large area of disturbance and its contact length with the river determines the sediment contribution rates, which varied spatially in a quadratic trend along the channel. Meanwhile, the sediment contribution of relatively small and dispersed exposed slopes could be quantified using a linear equation of the disturbance weighting indicator (DWI) composed of disturbed area and flow distance. These results would be helpful in assessing the environmental impact of engineering disturbances and optimizing mitigation measures.
Improving Urban Ecological Welfare Performance: An ST-LMDI Approach to the Yangtze River Economic Belt
Authors: Yang Jie , Li Zhigang
Published: August 2024

Enhancing urban ecological welfare performance is essential for achieving sustainable urban development and fostering a comprehensive regional green transformation. This study develops a quantitative assessment framework for urban ecological welfare performance, grounded in both the welfare of urban residents and their consumption of ecological resources. Employing the spatio-temporal Logarithmic Mean Divisia Index model to dissect the ecological welfare performance across 108 key prefecture-level cities within China’s Yangtze River Economic Belt, considering both temporal and spatial dimensions, the analysis reveals a “W”-shaped trajectory in the ecological welfare performance from 2006 to 2022, characterized by pronounced spatial disparities. Particularly in the downstream coastal regions and notably the Yangtze River Delta, advantages in social and economic structures, along with public fiscal outlays, contribute to a superior ecological welfare performance, exhibiting a notable spatial spillover effect. The study introduces six key factors—social benefit, economic benefit, population dispersion, population density in urban areas, urbanization scale, and ecological sustainability—to examine their influence on ecological welfare performance, uncovering substantial differences in the outcomes of temporal and spatial decomposition. Temporal decomposition indicates that economic benefit and urbanization scale are the primary drivers enhancing ecological welfare performance, whereas population dispersion is identified as the primary inhibitor. Spatial decomposition reveals that the determinants of above-average urban ecological welfare vary regionally and undergo dynamic shifts over time. Overall, a holistic understanding of the interplay among economic growth, ecological preservation, and the enhancement of residents’ welfare can inform the development and execution of tailored policies by local governments.
Patterns and Emerging Trends in Acute Poisoning with Substances of Abuse Used for Recreational Purposes in Adolescents: A Six-Year Multicentre Study
Authors: Turcu Teodora-Adela , Lescaie Andreea , Grama Andreea Rodica , Strătulă Andreea-Cătălina , Vincene Andreea-Iasmina , Grigoraș Laura-Maria , Jităreanu Cristina , Babeu Alina Maria , Gafencu Mihai , Crăciun Maria-Dorina , Chivu Carmen-Daniela , Baconi Daniela Luiza , Mihai Cristina Maria , Ulmeanu Coriolan Emil , Nițescu Gabriela Viorela
Published: August 2024

This six-year multicentre study investigated acute intentional poisoning with substances of abuse in adolescents to identify changes and patterns in substance use. Data from 562 adolescents were collected from three paediatric poison centres in Romania between January 2017 and December 2022. This study analysed the epidemiological and sociodemographic characteristics of the adolescents, including age, gender, place of residence, history of substance abuse, psychiatric history, and history of institutionalised care. The findings revealed that cannabis and new psychoactive substances (NPSs) are the most commonly implicated substances, each with distinct profiles among adolescents. Cannabis was involved in 46.1% of cases, with a significant association with urban residency. NPSs were identified as the second most prevalent substance, accounting for 39.3% of cases. These were more prevalent in rural areas and among patients with psychiatric disorders. Cannabis and NPSs were also the most commonly implicated substances in acute intentional poisoning cases with substances of abuse. These substances have distinct profiles among adolescents, including age, gender, residency area, history of substance abuse, psychiatric history, and institutional care. These findings underscore the necessity of targeted public health interventions and integrated care approaches to address substance use and related mental health issues in adolescents.
Assessing Patients beyond the Simple Optics of BMI: The Concomitant Role of Sarcopenia and BMI in Predicting Kidney Transplant Outcomes
Authors: Seet Christopher , Clementoni Laura , Akhtar Mohammed Rashid , Chandak Pankaj , Saoud Mohammed , Elsaadany Amr , Yaqoob Muhammad Magdi , Mohamed Ismail Heyder , Khurram Muhammad Arslan
Published: August 2024

Background: Body composition is associated with prognosis in many clinical settings, and patients undergoing kidney transplantation are often high risk with multiple comorbidities. We aimed to assess the effect of sarcopenia and body composition on transplant outcomes. Methods: We performed a retrospective analysis of 274 kidney transplants with CT scans within 3 years of transplantation. The skeletal muscle index (SMI) at the L3 vertebrae was used to evaluate sarcopenia (SMI < 40.31 cm2/m2 in males, <30.88 cm2/m2 in females). Sarcopenia, body mass index (BMI), and the visceral-to-subcutaneous-fat ratio (VSR) were assessed separately. We also used a composite BMI/sarcopenia measurement in four patient groups: BMI < 25/Non-Sarcopenic, BMI < 25/Sarcopenic, BMI > 25/Non-Sarcopenic, and BMI > 25/Sarcopenic. The outcomes measured were eGFR (1 and 3 months; and 1, 3, and 5 years), delayed graft function (DGF), rejection, major adverse cardiovascular events (MACE), and post-operative complications. Results: Sarcopenia was associated with an increased 1-year risk of MACE (OR 3.41, p = 0.036). BMI alone had no effect on function, DGF, MACE, or on other complications. High VSR was associated with a lower risk of DGF (OR 0.473, p = 0.016). When sarcopenia and BMI were assessed together, the BMI > 25/sarcopenic patients had the poorest outcomes, with increased risk of MACE (OR 26.06, p = 0.001); poorer eGFR at 1, 3, 12, and 36 months; (p < 0.05 at all timepoints), and poorer graft survival (p = 0.002). Conclusions: Sarcopenia alone is associated with an increased risk of MACE. Overweight sarcopenic patients are additionally at increased risk of graft loss and have poorer graft function for up to three years.
Evaluation of the Interaction between Carvacrol and Thymol, Major Compounds of Ptychotis verticillata Essential Oil: Antioxidant, Anti-Inflammatory and Anticancer Activities against Breast Cancer Lines
Authors: Taibi Mohamed , Elbouzidi Amine , Haddou Mounir , Baraich Abdellah , Ou-Yahia Douaae , Bellaouchi Reda , Mothana Ramzi A. , Al-Yousef Hanan M. , Asehraou Abdeslam , Addi Mohamed , Guerrouj Bouchra El , Chaabane Khalid
Published: August 2024

The objective of this study was to evaluate the antioxidant, anti-inflammatory, and anticancer properties of thymol, carvacrol, and their equimolar mixture. Antioxidant activities were assessed using the DPPH, ABTS, and ORAC methods. The thymol/carvacrol mixture exhibited significant synergism, surpassing the individual compounds and ascorbic acid in DPPH (IC50 = 43.82 ± 2.41 µg/mL) and ABTS (IC50 = 23.29 ± 0.71 µg/mL) assays. Anti-inflammatory activity was evaluated by inhibiting the 5-LOX, COX-1, and COX-2 enzymes. The equimolar mixture showed the strongest inhibition of 5-LOX (IC50 = 8.46 ± 0.92 µg/mL) and substantial inhibition of COX-1 (IC50 = 15.23 ± 2.34 µg/mL) and COX-2 (IC50 = 14.53 ± 2.42 µg/mL), indicating a synergistic effect. Anticancer activity was tested on MCF-7, MDA-MB-231, and MDA-MB-436 breast cancer cell lines using the MTT assay. The thymol/carvacrol mixture demonstrated superior cytotoxicity (IC50 = 0.92–1.70 µg/mL) and increased selectivity compared to cisplatin, with high selectivity indices (144.88–267.71). These results underscore the promising therapeutic potential of the thymol/carvacrol combination, particularly for its synergistic antioxidant, anti-inflammatory, and anticancer properties against breast cancer. This study paves the way for developing natural therapies against breast cancer and other conditions associated with oxidative stress and inflammation, leveraging the synergistic effects of natural compounds like thymol and carvacrol.
The Improvement of CrN Coatings Wear Resistance by Adjusting the Cycle Number of Electrochemical
Authors: Wang Xin , Wang Qianzhi , Zhou Fei , Kong Jizhou , Zhou Zhifeng
Published: August 2024

To further improve the sealing effect of electrochemical polarization (EP) on the CrN coatings, the EP treatment at different cycle numbers was conducted. The microstructure, mechanical, and tribological properties of CrN coatings were investigated. Findings indicated an elevation in oxygen content from 6.32% to 12.35% with increasing cycle number from 10 to 60 times, yet the crystal structure of CrN (111) and CrN (200) persisted. The X-ray photoelectron spectrum (XPS) and transmission electron microscope (TEM) revealed that a minimal quantity of oxides was produced. This led to a decrease in the coatings porosity from 16.79% to 5.83%. For this reason, the hardness of CrN coatings increased with a maximum degree of 18.3%, whilst the wear rate decreased with a maximum degree of 37.5% at the cycle number of 20 times.
Synthesis and Antimicrobial Evaluation of 2-[2-(9H-Fluoren-9-ylidene)hydrazin-1-yl]-1,3-thiazole Derivatives
Authors: Anusevičius Kazimieras , Stebrytė Ignė , Kavaliauskas Povilas
Published: August 2024

Fluorenyl-hydrazonothiazole derivatives 2–7 were synthesized by the Hantzsch reaction from 2-(9H-fluoren-9-ylidene)hydrazine-1-carbothioamide (1) and the corresponding α-halocarbonyl compounds in THF or 1,4-dioxane solvent. A base catalyst is not necessary for synthesising thiazoles, but it can shorten the reaction time. The antimicrobial properties of all synthesized compounds were screened for multidrug-resistant microorganism strains. The minimum inhibitory concentration of the tested compounds against Gram-positive bacteria and fungi was higher than 256 μg/mL, but several compounds had activity against Gram-positive strains.
3-Ethoxycarbonyl-1,4-benzodioxin-2-carboxylic Acid
Authors: Armano Edoardo , Giraudo Alessandro , Morano Camillo , Pallavicini Marco , Bolchi Cristiano
Published: August 2024

3-Ethoxycarbonyl-1,4-benzodioxin-2-carboxylic acid, a novel 2,3-disubstituted benzodioxin, was prepared from readily available 1,4-benzodioxin-2-carboxylic acid by lithiation at C(3) and a reaction with the electrophile ethyl chloroformate. The analytical characterization of the product was performed via IR, 1H-NMR, 13C-NMR, HRMS, and HPLC-UV. Due to the unsymmetrically disubstituted unsaturation, the obtained monoester of 1,4-benzodioxin-2,3-dicarboxylic acid is a building block of great potential in the synthesis of a variety of compounds containing the benzodioxin or benzodioxane scaffold.
Study on the Properties of TiC Coating Deposited by Spark Discharge on the Surface of AlFeCoCrNiCu High-Entropy Alloy
Authors: Wang Ying , Nie Cheng , Wang Shengding , Gong Pan , Zhang Mao , Hu Zhigang , Li Bin
Published: August 2024

Titanium carbide (TiC) coatings were prepared on the surface of AlFeCoCrNiCu high-entropy alloy blocks using electro-spark deposition (ESD). The microhardness and corrosion resistance of the TiC coatings prepared under different voltage and capacitance process parameters were studied. The research shows that the maximum microhardness of the TiC coating on sample 4 (working voltage of 20 V, working capacitance of 1000 μF) is 844.98 HV, which is 81.5% higher than the microhardness of the substrate. This is because the deposition energy increases with the increase in voltage, and the adhesion and aggregation between the coating and the substrate are enhanced, increasing the hardness of the coating. It is worth noting that excessive deposition energy can increase surface defects and reduce the microhardness of the coating surface. Electrochemical testing analysis shows that the corrosion current density of the TiC coating is the lowest (9.475 × 10−7 ± 0.06 × 10−7), and the coating impedance is the highest (2.502 × 103 Ω·com2). The absolute phase angle value is the highest (about 72°). The above indicates that the TiC coating prepared with a working voltage of 20 V and a working capacitance of 1000 μF has better microhardness and corrosion resistance.
The Influence of Pore-Forming Diluents on Porous Structure, Thermal and Sorption Properties of the Divinylbenzene and Glycidyl Methacrylate Copolymers
Authors: Sobiesiak Magdalena , Parcheta Monika
Published: August 2024

The aim of this work was the characterization of polymer microspheres obtained by the suspension polymerization of divinylbenzene (DVB) and glycidyl methacrylate (GMA), depending on the pore-forming diluents and molar ratio of monomers. The assessed properties included the chemical and porous structure, thermal stability, and sorption capacity of the obtained polymers towards methylene blue. The abovementioned characteristic was carried out for two series of copolymers with molar ratios of monomers of 1:2, 1:1 and 2:1, synthetized with toluene and a mixture of decanol and benzyl alcohol. The structure of the polymers was confirmed by FTIR and elemental analysis. The results of TGA demonstrated the main influence on thermal stability was the composition of polymers, whereas the impact of porogens was negligible. The SBET varied in the range of 12–534 m2g−1 for polymers obtained with toluene and 0–396 m2g−1 with the mixture of alcohols. Toluene enhanced the formation of micro- and mesopores, while the mixture of alcohols enhanced the creation of meso- and macropores. For the polymers prepared with toluene, their effectiveness in water purification decreases in the following order: DVB-GMA 2:1 > DVB-GMA 1:1 > DVB-GMA 1:2, according to the decreasing values of porous structure parameters. In the case of a series obtained with a mixture of alcohols, such correlation was not observed.
Chloride Penetration of Surface-Coated Concrete: Review and Outlook
Authors: Liao Jing , Wang Yuchi , Sun Xiping , Wang Yuanzhan
Published: August 2024

Concrete coatings show significant promise in shielding concrete substrates from corrosion by effectively resisting harmful ions and moisture. Thanks to their practicality, high efficiency, and cost-effectiveness, coatings are considered a potent technique for enhancing the chloride resistance of reinforced concrete structures. Over recent decades, extensive research has concentrated on employing coatings to bolster concrete’s ability to withstand chloride penetration. This paper provides a holistic review of the current studies on chloride infiltration in concrete surfaces treated with coating materials, primarily focused on chloride resistance improvement efficiency and chloride transport modeling. Firstly, by comparing the functions of assorted coatings, four inherent protection mechanisms are summarized and elaborated thoroughly. Afterwards, the chloride resistance improvement efficiency of assorted coatings reported in current studies are reviewed and compared in great detail, with a specific focus on inorganic, organic, and organic–inorganic composite coatings. Furthermore, the theoretical research about methodologies for chloride transport behavior prediction is summarized. Finally, this paper outlines the potential research directions in this field and the theoretical, technical, and practical application challenges. This review not only identifies critical areas necessitating further investigation and problem-solving in this domain but also aids in selecting appropriate coating materials and refining corrosion management strategies.
Design and Prototyping of a Collaborative Station for Machine Parts Assembly
Authors: Emiliani Federico , Bajrami Albin , Costa Daniele , Palmieri Giacomo , Polucci Daniele , Leoni Chiara , Callegari Massimo
Published: August 2024

Collaboration between humans and machines is the core of the Industry 5.0 paradigm, and collaborative robotics is one the most impactful enabling technologies for small and medium Enterprises (SMEs). In fact, small batch production and high levels of product customization make parts assembly one of the most challenging operations to be automated, and it often still depends on the versatility of human labor. Collaborative robots, for their part, can be easily integrated in this productive paradigm, as they have been specifically developed for coexistence with human beings. This work investigates the performance of collaborative robots in machine parts assembly. Design and research activities were carried out as a case study of industrial relevance at the i-Labs industry laboratory, a pole of innovation that is briefly introduced at the beginning of the paper. A fully-functional prototype of the cobotized station was realized at the end of the project, and several experimental tests were performed to validate the robustness of the assembly process as well as the collaborative nature of the application.
Fault Detection of Rotating Machines Using poly-Coherent Composite Spectrum of Measured Vibration Responses with Machine Learning
Authors: Almutairi Khalid , Sinha Jyoti K. , Wen Haobin
Published: August 2024

This study presents an efficient vibration-based fault detection method for rotating machines utilising the poly-coherent composite spectrum (pCCS) and machine learning techniques. pCCS combines vibration measurements from multiple bearing locations into a single spectrum, retaining amplitude and phase information while reducing background noise. The use of pCCS significantly reduces the number of extracted parameters in the frequency domain compared to using individual spectra at each measurement location. This reduction in parameters is crucial, especially for large industrial rotating machines, as processing and analysing extensive datasets demand significant computational resources, increasing the time and cost of fault detection. An artificial neural network (ANN)-based machine learning model is then employed for fault detection using these reduced extracted parameters. The methodology is developed and validated on an experimental rotating machine at three different speeds: below the first critical speed, between the first and second critical speeds, and above the second critical speed. This range of speeds represents the diverse dynamic conditions commonly encountered in industrial settings. This study examines both healthy machine conditions and various simulated fault conditions, including misalignment, rotor-to-stator rub, shaft cracks, and bearing faults. By combining the pCCS technique with machine learning, this study enhances the reliability, efficiency, and practical applicability of fault detection in rotating machines under varying dynamic conditions and different machine conditions.
A Hybrid Intelligent Optimization Algorithm Based on a Learning Strategy
Authors: Deng Wanyi , Ma Xiaoxue , Qiao Weiliang
Published: August 2024

To overcome the limitations of single-type intelligent optimization algorithms prone to becoming stuck in local optima for complex problems, a hybrid intelligent optimization algorithm named SDIQ is proposed. This algorithm combines simulated annealing (SA), differential evolution (DE), quantum-behaved particle swarm optimization (QPSO), and improved particle swarm optimization (IPSO) into a unified framework. Initially, SA is used to explore the solution space and guide individuals toward preliminary optimization. The individuals are then ranked by fitness and divided into three subpopulations, each optimized by DE, QPSO, and IPSO, respectively. After each iteration, probabilistic learning based on fitness logarithms facilitates mutual learning among subpopulations, enabling global information sharing and improvement. The experimental results demonstrate that SDIQ exhibits strong global search capability and stability in solving both standard test functions and real-world engineering problems. Compared to traditional algorithms, SDIQ enhances global convergence and solution efficiency by integrating multiple optimization strategies and leveraging inter-individual learning, providing an effective solution for complex optimization problems.
Intelligent Retrieval and Secure Acquisition of Embedded Data
Authors: Chen Shuzhen , Shi Kaiquan
Published: August 2024

Data has attributes, and synchronous changes between data and attributes are the basic characteristics of a type of data: under the condition of supplementing (deleting) some attributes, some data elements are deleted (supplemented) from data. The attributes of data elements follow the conjunctive normal form. Based on the dynamic mathematical model P-sets, firstly, the conception and generation criteria of embedded data are proposed, and the inference theory of embedded data are studied. Secondly, intelligent retrieval and retrieval theorems for embedded data are proposed. Then, intelligent retrieval and secure acquisition algorithms for embedded data are designed. Finally, an application example is presented.
Co-Evolutionary Algorithm for Two-Stage Hybrid Flow Shop Scheduling Problem with Suspension Shifts
Authors: Huang Zhijie , Huang Lin , Li Debiao
Published: August 2024

Demand fluctuates in actual production. When manufacturers face demand under their maximum capacity, suspension shifts are crucial for cost reduction and on-time delivery. In this case, suspension shifts are needed to minimize idle time and prevent inventory buildup. Thus, it is essential to integrate suspension shifts with scheduling under an uncertain production environment. This paper addresses the two-stage hybrid flow shop scheduling problem (THFSP) with suspension shifts under uncertain processing times, aiming to minimize the weighted sum of earliness and tardiness. We develop a stochastic integer programming model and validate it using the Gurobi solver. Additionally, we propose a dual-space co-evolutionary biased random key genetic algorithm (DCE-BRKGA) with parallel evolution of solutions and scenarios. Considering decision-makers’ risk preferences, we use both average and pessimistic criteria for fitness evaluation, generating two types of solutions and scenario populations. Testing with 28 datasets, we use the value of the stochastic solution (VSS) and the expected value of perfect information (EVPI) to quantify benefits. Compared to the average scenario, the VSS shows that the proposed algorithm achieves additional value gains of 0.9% to 69.9%. Furthermore, the EVPI indicates that after eliminating uncertainty, the algorithm yields potential improvements of 2.4% to 20.3%. These findings indicate that DCE-BRKGA effectively supports varying decision-making risk preferences, providing robust solutions even without known processing time distributions.