bluuebunny/crossref_metadata_2025 huggingface dataset:
Teaching to (un)learn: enacting social justice in the identity development of multilingual/Latinx/BIPOC teacher candidates
Authors: Morales-Alexander Yasmin
Published: May 2023

Purpose

This paper aims to describe how engaging in an inquiry-as-stance reflexive approach informed the design of a graduate-level early childhood social studies methods course to support the professional identity development of multilingual/Latinx, Black, Indigenous, people of color (ML/L/BIPOC) teacher candidates.

Design/methodology/approach

Nested within a theoretical construct that articulates “unlearning as a disruptive force” (Dunne, 2016), the author used a parallel process that modeled the teaching of social studies methods grounded in critical reflections of students’ cultural and linguistic assets. In so doing, the author shares how she models culturally and linguistically responsive-sustaining pedagogy in practice.

Findings

The findings illustrate that in this course, students begin unlearning internalized deficit narratives that they have been socialized to believe about themselves and, often, their students.

Research limitations/implications

This study is based on only four semesters of teaching one graduate-level methods course to ML/L/BIPOC early childhood educators at one institution, research results may lack generalizability. Therefore, researchers are encouraged to test the proposed propositions further.

Originality/value

Through unlearning, ML/L/BIPOC learn to recognize their assets, dispositions, skills and capacities more fully and, thus, are more able to enact culturally responsive-sustaining pedagogy once in their own classrooms. As such, this study has value for applying critical, identity-centered and asset-based pedagogies in teacher preparation programs.
Humble leadership and project success: underpinning service-oriented organizational citizenship behavior and task complexity
Authors: Naeem Mian Nisma , Malik Muhammad Imran , Hussain Saddam
Published: May 2023

Purpose

The aim of the study is to investigate the relationship between humble leadership, project success, and service-oriented organizational citizenship behavior (OCB) and how task complexity may moderate this relationship. The study aims to determine if humble leaders are more likely to promote service-oriented OCB among team members and if this behavior in turn leads to greater project success, especially in complex task environments. These relationships are examined through the lens of the conservation of resources theory.

Design/methodology/approach

The data were collected from the employees working in software companies using a closed-ended questionnaire, and a total of 214 complete questionnaires were analyzed. The research model was tested using structural equation modeling with the help of Smart PLS 3 software.

Findings

Humble leadership is positively associated with service-oriented organizational citizenship behavior (OCB), which in turn is linked to project success. Task complexity does not appear to have a significant impact on this relationship.

Practical implications

Humble leadership is positively related to IT project success through its influence on service-oriented organizational citizenship behavior and task complexity. Implications include the importance of fostering a humble leadership style to enhance IT project success, as well as the potential benefits of promoting service-oriented behavior among employees. It also highlights the need to consider task complexity when evaluating project success.

Originality/value

The research explores the relationship between “humble leadership” and project success, and how it relates to “service-oriented organizational citizenship behavior” and “task complexity”. It presents an original perspective on the role of leadership in project success and the impact of organizational culture on project outcomes through the lens of the conservation of resources theory.
Family firms, client importance, and auditor reporting behavior: evidence from China
Authors: Rahman Md Jahidur , Zhu Hongtao , Jiang Xinyi
Published: May 2023

Purpose

This study aims to investigate whether auditors compromise their independence for economically important clients in family business settings.

Design/methodology/approach

The authors empirically examine the research question based on China for the years 2011 to 2020. The dependent variable is the auditors’ propensity to issue modified audit opinions, which is a proxy for auditor independence. The authors use relative client audit fees as a proxy for client importance. To address endogeneity issues in the selection of family firms, the authors use the two-stage least squares regression model and, subsequently, the propensity score matching and Hausman firm fixed effect modeling.

Findings

This study reveals that the propensity to issue modified audit opinions is positively correlated with client importance. Big-N auditors are more likely to issue modified audit opinions for their economically important family firm clients, whereas such evidence is not found for non-Big-N auditors. Results are consistent and robust to endogeneity test and sensitivity analysis.

Originality/value

This study enriches the literature on auditor independence and the effect of family firms’ ownership structure factors on audit reporting behavior for their economically important clients. Findings may prove useful for managers and practitioners interested in family business.
Who knows it better? Reassessing human qualitative analysis with text mining
Authors: Marcolin Carla Bonato , Diniz Eduardo Henrique , Becker João Luiz , de Oliveira Henrique Pontes Gonçalves
Published: May 2023

Purpose

In a context where human–machine interaction is growing, understanding the limits between automated and human-based methods may leverage qualitative research. This paper aims to compare human and machine analyses, highlighting the challenges and opportunities of both approaches.

Design/methodology/approach

This study applied qualitative secondary analysis (QSA) with machine learning-based text mining on qualitative data from 25 interviews previously analyzed with traditional qualitative content analysis.

Findings

By analyzing both techniques' strengths and weaknesses, this study complements the results from the original research work. The previous human model failed to point to a particular aspect of the case, while the machine analysis did not recognize the sequence of time in the interviewee's discourse.

Originality/value

This study demonstrates that combining content analysis with text mining techniques improves the quality of the research output. Researchers may, therefore, better handle biases from humans and machines in traditional qualitative and quantitative research.
Five key areas to consider before using gamification in learning and development
Authors: Parkerson Rebecca
Published: May 2023

Purpose

The purpose of this paper is to inform readers about the use of gamification and active learning as effective learning methods, particularly in hybrid, diverse and global organisations.

Design/methodology/approach

This study takes an advisory approach based upon experienced delivery of blended learning and gamification in an human resources (HR), training and development environment.

Findings

The introduction of gamification and blended learning is like any other method of development. It is only as good as the planning. Gamification as a novel way of learning will not last the distance without setting objectives, planning how to reach them, evaluation and ongoing support for behavioural change.

Originality/value

To the best of the authors’ knowledge, this paper is the viewpoint of the author and has not been published elsewhere.
Nonword reading and other reading‐related skills in Down syndrome
Authors: Muscat Loredana , Grech Helen
Published: May 2023

The performance of children and young adults with Down syndrome (DS) on reading subskills and nonword reading was investigated. The performance of the participants with DS (N = 42) was compared to that of typically developing (N = 36) peers matched on fluid intelligence abilities. The study accounted for the different depths in orthography presented by the two languages. The independent samples t‐test, Mann–Whitney U‐test, ANCOVA and correlation analysis were used to analyse the data. This study identified that the participants with DS had several strengths, such as nonword reading, visual discrimination (VD) and phonological awareness. Verbal short‐term memory, visual perceptual processing skills other than VD and rhyming skills were identified as weaker in DS compared with the control group. Results call for educators to expose readers with DS to a phonological approach to reading while accommodating difficulties in VSTM.
United Kingdom: Political Developments and Data in 2022
Authors: MIDDLETON ALIA
Published: May 2023

Turmoil characterised politics in the United Kingdom in 2022, with the year seeing three Prime Ministers, the death of Queen Elizabeth II and a deepening economic crisis. Partygate continued to loom large over the Johnson administration, and after a tumultuous few days with mass ministerial resignations in July, Johnson resigned. His successor, Liz Truss, became the shortest‐serving Prime Minister in British history, resigning after 49 days. Rishi Sunak became the third Prime Minister since the 2019 general election. The economy was a key area of concern in 2022, with rising inflation worsening a cost of living crisis and fuelling a series of public sector strikes.
Albumin administration in septic shock—Protocol for post‐hoc analyses of data from a multicentre RCT
Authors: Meyhoff Tine Sylvest , Granholm Anders , Hjortrup Peter Buhl , Sivapalan Praleene , Lange Theis , Laake Jon Henrik , Cronhjort Maria , Jakob Stephan M. , Cecconi Maurizio , Nalos Marek , Ostermann Marlies , Malbrain Manu L. N. G. , Møller Morten Hylander , Perner Anders
Published: May 2023

Background

Intravenous (IV) albumin is suggested for patients with septic shock who have received large amounts of IV crystalloids; a conditional recommendation based on moderate certainty of evidence. Clinical variation in the administration of IV albumin in septic shock may exist according to patient characteristics and location.

Methods

This is a protocol and statistical analysis plan for a post‐hoc secondary study of the Conservative versus Liberal Approach to Fluid Therapy of Septic Shock in Intensive Care (CLASSIC) RCT of 1554 adult ICU patients with septic shock. We will assess if specific baseline characteristics or trial site are associated with the administration of IV albumin during ICU stay using Cox models with competing events. All models will be adjusted for the treatment allocation in CLASSIC (restrictive vs. standard IV fluid), and all analyses will consider competing events (death, ICU discharge and loss‐to‐follow‐up). We will present results as hazard ratios with 95% confidence intervals and p‐values for the associations of baseline characteristics or site with IV albumin administration. Between‐group differences (interactions) will be assessed using p‐values from likelihood ratio tests. All results will be considered exploratory only.

Discussion

This secondary study of the CLASSIC RCT may yield important insight into potential practice variation in the administration of albumin in septic shock.
Experiences of isolation in patients in the intensive care unit during the COVID‐19 pandemic
Authors: Køster Allan , Meyhoff Christian Sylvest , Andersen Lars Peter Kloster
Published: May 2023

Background

During the COVID‐19 pandemic, patients in the intensive care unit have been subjected to strict isolation precautions, and potentially long and complicated patient courses. The aim of the study is to provide an investigation of the experiences of isolation in COVID‐19‐positive patients in the ICU during the first phase of the COVID‐19 pandemic in Denmark.

Methods

The study was performed in a 20‐bed ICU at a university hospital in Copenhagen, Denmark. The study is based on a phenomenological framework, Phenomenologically Grounded Qualitative Research. This approach provides insights into the tacit, pre‐reflective and embodied dimensions of the specific experience under investigation. Methods included a combination of in‐depth structured interviews with ICU patients 6–12 months after ICU discharge, and observations from inside the isolated patient rooms. The descriptions of experiences gathered through the interviews were subjected to systematic thematic analysis.

Results

Twenty‐nine patients were admitted to the ICU in the period 10 March and 19 May 2020. A total of six patients was included in the study. Themes consistently reported across all patients included (1) being objectified to degrees that implied self‐alienation; (2) feeling a sense of being in captivity; (3) being in an experiential state of surrealism, and finally (4) experiencing extreme loneliness and intercorporeal deprivation.

Conclusion

This study provided further insights into the liminal patient experiences of being isolated in the ICU due to COVID‐19. Robust themes of experience were achieved through an in‐depth phenomenological approach. Although, similarities in experiences compared to other patient groups exist, the precarious situation constituted by COVID‐19 lead to significant intensifications across multiple parameters.
Hypereosinophilic syndrome with cutaneous manifestations successfully treated with Dupilumab as a sole agent: A case report
Authors: Scully Kayla , Shao Emily , Banney Leith , Weston Helen
Published: May 2023

Hypereosinophilic syndrome describes a process in which eosinophils in the peripheral blood are persistently increased, with variable clinical manifestations. Finding efficacious treatments for this disease can be challenging. This case describes a 72‐year‐old man with idiopathic hypereosinophilic syndrome with cutaneous manifestations who was successfully treated with dupilumab as a single agent therapy. There was complete clinical and biochemical resolution of disease (eosinophils levels decreased from 4.13 to 0.92) without complications.
The use of basic fibroblast growth factor to improve vocal function: A systematic review and meta‐analysis
Authors: Hamilton Nick J. I. , Saccente‐Kennedy Brian , Ambler Gareth
Published: May 2023

Objectives

This systematic review and meta‐analysis examines if intralaryngeal injection of basic fibroblast growth factor 2 (FGF2) can improve voice outcomes in those with vocal disability.

Design

A Systematic review of original human studies reporting voice outcomes following intra‐laryngeal injection of basic fibroblast growth factor 2 in those with vocal dysfunction. Databases searched were Medline (1946–July 2022), Embase (1947–July 2022), Cochrane database and Google Scholar.

Setting

Secondary or tertiary care centres that undertook the management of voice pathology Hospital.

Participants

Inclusion criteria were original human studies reporting voice outcome measurements following intralaryngeal injection of FGF2 to treat vocal fold atrophy, vocal fold scarring, vocal fold sulcus or vocal fold palsy. Articles not written in English, studies that did not include human subjects and studies where voice outcome measures were not recorded before and after FGF2 injection were excluded from the review.

Main Outcome Measures

The primary outcome measure was maximum phonation time. Secondary outcome measures included acoustic analysis, glottic closure, mucosal wave formation, voice handicap index and GRBAS scale.

Results

Fourteen articles were included out of a search of 1023 and one article was included from scanning reference lists. All studies had a single arm design without control groups. Conditions treated were vocal fold atrophy (n = 186), vocal cord paralysis (n = 74), vocal fold fibrosis (n = 74) and vocal fold sulcus (n = 56). A meta‐analysis of six articles reporting on the use of FGF2 in patients with vocal fold atrophy showed a significant increase of mean maximum phonation time of 5.2 s (95% CI: 3.4–7.0) at 3–6 months following injection. A significant improvement in maximum phonation time, voice handicap index and glottic closure was found following injection in most studies assessed. No major adverse events were reported following injection.

Conclusions

To date, intralaryngeal injection of basic FGF2 appears to be safe and it may be able to improve voice outcomes in those with vocal dysfunction, especially vocal fold atrophy. Randomised controlled trials are needed to further evaluate efficacy and support the wider use of this therapy.
Reflections on teaching and learning during the omicron wave of the COVID‐19 pandemic and economic inflation
Authors: Khareedi Rohini , Ratnaweera Priyadarshanee Manorika
Published: May 2023

The pandemic and the rising living costs have affected teaching and learning practices. These changes have impacted teaching faculty and students alike. This article is an analytical reflection of our experiences of teaching and learning during the omicron wave of the pandemic and rising economic inflation. This paper highlights some of our key observations. The reflective process has challenged some of our preconceptions. It has also helped highlight some questions and contradictions on teaching and learning in this context which may provide a reference for future research.
Effective stress and shear strength parameters of unsaturated soils as affected by compaction and subsequent shearing
Authors: Huang Xinjun , Ren Tusheng , Horn Rainer
Published: May 2023

Wheeling induced compression and shearing forces are main stresses accounting for soil deformation and changes of hydraulic, gaseous and thermal properties. There are reports about the combined effects of compaction and subsequent shearing on soil hydraulic properties, but their consequences on soil strength properties (i.e., effective stress and shear strength) need to be further analysed. This study investigated the dynamics of soil mechanical properties as affected by pore water pressure () during compaction and shearing. Soil samples from an A‐horizon of Gleysols derived from glacial sediment and a Stagnic Luvisol from loess were analysed. The repacked and structured samples were compressed under static and cyclic loading and then sheared at two speeds (0.3 and 2.0 mm min−1) with three loading levels (50, 100, and 200 kPa). During each stress application, the , chi factor (χ) and effective stress () were measured and calculated. The shear strength (), angle of internal friction () and cohesion (), were determined and fitted by the Mohr–Coulomb failure criterion. The results showed that compaction and shearing increased and χ in all homogenized soils while on structured soils this phenomenon only occurred when the applied loading stress exceeded the soil precompression stress. The increased resulted in soil hydraulic and mechanical stresses, which ultimately reduced the , especially at −6 kPa initial matric potential. Soils with finer texture, higher loading stresses and faster shear speed normally exhibited more reduced values. The structured soil had higher values with higher and compared to the homogenized soils. The changes of at high loading stress (i.e., 200 kPa) may overlap the normal pattern of the Mohr–Coulomb failure line that results from the theoretical Mohr envelope. Thus, to minimize the destruction of soil structure and stability induced by wheeling, it is important to consider field water content, traffic loading and wheeling speed.
Long‐term fertilization and plastic film mulching modify temporal incorporation of 13C/15N‐labelled particulate organic matter
Authors: Jin Xinxin , Bol Roland , An Tingting , Zheng Lihong , Li Shuangyi , Pei Jiubo , Wang Jingkuan
Published: May 2023

Plastic film mulching (PFM) is critical for agricultural planting and maximizing production in semiarid and arid areas. Particulate organic matter (POM) is assumed to be a sensitive indicator for evaluating the effects of different agricultural practices on soil fertility and the soil organic carbon (SOC) pool. Soil aggregates have the function of ‘wrap’ and protect the POM stored in them. However, there is limited information regarding how PFM and fertilization jointly influence the dynamic changes of newly added stalk‐derived POM in brown earth. Consequently, an in‐depth study of the fate of carbon (C) and nitrogen (N) derived from maize stalk residues within the particulate organic carbon (POC) and particulate organic nitrogen (PON) fractions in soil aggregates was undertaken. Its outcome would contribute to better predictions on the active organic matter components sequestered in the soil. The dynamics and accumulation of newly added maize stalk C and N as POC and PON in different soil aggregates (using the dry sieving method divided into >2, 1–2, 0.25–1 and <0.25 mm) were analysed by an in situ 13C/15N‐tracing technique under PFM and different fertilization treatments. Over 360 days of cultivation, the POC and PON contents were significantly (p < 0.05) larger in the nitrogen (N) and organic manure (M) treatments than in the MN (manure combined with nitrogen) and Control treatments. The PFM treatment accelerated the decomposition of maize stalk C in the N fertilizer treatment, with an increase of 64% in stalk‐derived POC after the 1‐day cultivation period. Stalk‐derived POM tended to accumulate in <0.25 mm microaggregates in the early cultivation period and then decreased rapidly with the extension of the cultivation period affected by PFM coupled with fertilization. However, stalk‐derived POM accumulation in macroaggregates (>0.25 mm) fluctuated over the 360‐day cultivation period. Accordingly, PFM application and fertilization practices had important effects on the accumulation of newly added stalk‐derived POM in soil aggregates. We conclude that the accumulation of maize residue POM was primarily affected by soil fertilization type, rather than by the presence or absence of PFM. These results provide new insights into agricultural management strategies for improving soil carbon sequestration capacity.
Cognitive function in primary and secondary progressive multiple sclerosis: A multiparametric magnetic resonance imaging study
Authors: Mistri Damiano , Cacciaguerra Laura , Valsasina Paola , Pagani Elisabetta , Filippi Massimo , Rocca Maria A.
Published: May 2023

Background and purpose

The differences in cognitive function between primary progressive and secondary progressive multiple sclerosis (MS) remain unclear. We compared cognitive performance between primary progressive multiple sclerosis (PPMS) and secondary progressive multiple sclerosis (SPMS), and explored the structural and functional magnetic resonance imaging (MRI) correlates of their cognitive functions.

Methods

Seventy‐five healthy controls and 183 MS patients (60 PPMS and 123 SPMS) underwent 3.0‐T MRI. MS patients were administered the Brief Repeatable Battery of Neuropsychological Tests; cognitive domain z‐scores were calculated and then averaged to obtain a measure of global cognition. Using hierarchical linear regression analysis, the contribution of lesion volumes, normalized brain volumes, white matter (WM) fractional anisotropy (FA) and mean diffusivity abnormalities, and resting state (RS) functional connectivity (FC) alterations to global cognition in PPMS and SPMS was investigated.

Results

PPMS and SPMS had similar z‐scores in all investigated cognitive domains. Poor global cognitive function was associated with decreased FA of the medial lemniscus (ΔR
2 = 0.11, p = 0.011) and lower normalized gray matter volume (ΔR
2 = 0.29, p < 0.001) in PPMS, and with decreased FA of the fornix (ΔR
2 = 0.35, p < 0.001) and lower normalized WM volume (ΔR
2 = 0.05; p = 0.034) in SPMS.

Conclusions

PPMS and SPMS had similar neuropsychological performance. Cognitive dysfunction in PPMS and SPMS was related to distinct patterns of structural MRI abnormalities and involvement of different WM tracts, whereas RS FC alterations did not contribute to explaining their global cognitive functioning.
Regulation of PARP1 and its apoptotic variant activity by single‐stranded DNA
Authors: Deeksha Waghela , Abhishek Suman , Giri Jyotsnendu , Rajakumara Eerappa
Published: May 2023

PARP1 is a nuclear protein involved in the maintenance of genomic stability. It catalyses the formation of poly(ADP‐ribose) (PAR) to recruit repair proteins at the site of DNA lesions, such as double‐strand and single‐strand breaks. In the process of DNA replication or repair, there could occur stretch of ssDNA, usually protected by ssDNA binding proteins, but when present in abundance can turn into DNA beaks and cause cell death. PARP1 is an extremely sensitive sensor of DNA breaks; however, the interaction of PARP1 with single‐stranded DNA (ssDNA) remains unexplored. Here, we report that the two Zn‐fingers, ZnF1 and ZnF2, of PARP1, mediate high‐affinity recognition of ssDNA. Our studies suggest that although PAR and ssDNA are chemical analogues, they are recognized by a distinct set of domains of PARP1, yet PAR not only induces dislodging of ssDNA from PARP1 but also hampers the ssDNA‐dependent PARP1 activity. It is noteworthy that PAR carrier apoptotic fragment PARP1ΔZnF1–2 gets cleaved from PARP1 to facilitate apoptosis, leaving behind the DNA‐bound ZnF1‐ZnF2PARP1. Our studies demonstrate that the PARP1ΔZnF1–2 is competent for ssDNA‐dependent stimulation only in the presence of another apoptotic fragment ZnF1‐ZnF2PARP1, suggesting the indispensability of DNA‐bound ZnF1‐ZnF2PARP1 dual domains for the same.
Metabolism‐related biomarkers, molecular classification, and immune infiltration in diabetic ulcers with validation
Authors: Ma Xiao‐Xuan , Zhang Ying , Jiang Jing‐Si , Ru Yi , Luo Ying , Luo Yue , Fei Xiao‐Ya , Song Jian‐Kun , Ma Xin , Li Bin , Tan Yi‐Mei , Kuai Le
Published: May 2023

Diabetes mellitus (DM) can lead to diabetic ulcers (DUs), which are the most severe complications. Due to the need for more accurate patient classifications and diagnostic models, treatment and management strategies for DU patients still need improvement. The difficulty of diabetic wound healing is caused closely related to biological metabolism and immune chemotaxis reaction dysfunction. Therefore, the purpose of our study is to identify metabolic biomarkers in patients with DU and construct a molecular subtype‐specific prognostic model that is highly accurate and robust. RNA‐sequencing data for DU samples were obtained from the Gene Expression Omnibus (GEO) database. DU patients and normal individuals were compared regarding the expression of metabolism‐related genes (MRGs). Then, a novel diagnostic model based on MRGs was constructed with the random forest algorithm, and classification performance was evaluated utilizing receiver operating characteristic (ROC) analysis. The biological functions of MRGs‐based subtypes were investigated using consensus clustering analysis. A principal component analysis (PCA) was conducted to determine whether MRGs could distinguish between subtypes. We also examined the correlation between MRGs and immune infiltration. Lastly, qRT‐PCR was utilized to validate the expression of the hub MRGs with clinical validations and animal experimentations. Firstly, 8 metabolism‐related hub genes were obtained by random forest algorithm, which could distinguish the DUs from normal samples validated by the ROC curves. Secondly, DU samples could be consensus clustered into three molecular classifications by MRGs, verified by PCA analysis. Thirdly, associations between MRGs and immune infiltration were confirmed, with LYN and Type 1 helper cell significantly positively correlated; RHOH and TGF‐β family remarkably negatively correlated. Finally, clinical validations and animal experiments of DU skin tissue samples showed that the expressions of metabolic hub genes in the DU groups were considerably upregulated, including GLDC, GALNT6, RHOH, XDH, MMP12, KLK6, LYN, and CFB. The current study proposed an auxiliary MRGs‐based DUs model while proposing MRGs‐based molecular clustering and confirmed the association with immune infiltration, facilitating the diagnosis and management of DU patients and designing individualized treatment plans.
Long non‐coding RNA as a novel biomarker and therapeutic target in aggressive B‐cell non‐Hodgkin lymphoma: A systematic review
Authors: Khanmohammadi Shaghayegh , Fallahtafti Parisa
Published: May 2023

Cancer initiation and progression have been associated with dysregulated long non‐coding RNA (lncRNA) expression. However, the lncRNA expression profile in aggressive B‐cell non‐Hodgkin lymphoma (NHL) has not been comprehensively characterized. This systematic review aims to evaluate the role of lncRNAs as a biomarker to investigate their future potential in the diagnosis, real‐time measurement of response to therapy and prognosis in aggressive B‐cell NHL. We searched PubMed, Web of Science, Embase and Scopus databases using the keywords “long non‐coding RNA”, “Diffuse large B‐cell lymphoma”, “Burkitt's lymphoma” and “Mantle cell lymphoma”. We included studies on human subjects that measured the level of lncRNAs in samples from patients with aggressive B‐cell NHL. We screened 608 papers, and 51 papers were included. The most studied aggressive B‐cell NHL was diffuse large B‐cell lymphoma (DLBCL). At least 79 lncRNAs were involved in the pathogenesis of aggressive B‐cell NHL. Targeting lncRNAs could affect cell proliferation, viability, apoptosis, migration and invasion in aggressive B‐cell NHL cell lines. Dysregulation of lncRNAs had prognostic (e.g. overall survival) and diagnostic values in patients with DLBCL, Burkitt's lymphoma (BL), or mantle cell lymphoma (MCL). Furthermore, dysregulation of lncRNAs was associated with response to treatments, such as CHOP‐like chemotherapy regimens, in these patients. LncRNAs could be promising biomarkers for the diagnosis, prognosis and response to therapy in patients with aggressive B‐cell NHL. Additionally, lncRNAs could be potential therapeutic targets for patients with aggressive B‐cell NHL like DLBCL, MCL or BL.
Behavioral health integration in the Program of All‐Inclusive Care for the Elderly (PACE): A scoping review
Authors: Fleet Alexa , Shalev Daniel , Spaeth‐Rublee Brigitta , Patterson Taryn , Wardlow Liane , Simoun Alya , Tomy Meril , Pincus Harold Alan
Published: May 2023

Background

The Program of All‐inclusive Care for the Elderly (PACE) is a community‐based care model that delivers collaborative care via an interdisciplinary team to meet the medical and social needs of older adults eligible for nursing home placement. Fifty‐nine percent of PACE participants are reported to have at least one psychiatric disorder. PACE organizations (POs) function through an interdisciplinary model of care, but a behavioral health (BH) provider is not a mandated role on the interdisciplinary team. Published literature regarding how POs integrate and provide BH services is limited; however, the National PACE Association (NPA) and select POs have made significant contributions to behavioral health integration (BHI) efforts in PACE.

Methods

PubMED, EMBASE, and PsycINFO were searched for articles published between January 2000 and June 2022; hand‐searching was also conducted. Research articles and items involving BH components or programming in POs were included. Evidence of BH programming and initiatives at the organization and national level was summarized.

Results

This review reported on nine primary items addressing BH in POs from 2004 to 2022. It found evidence of successful BH initiatives in PACE and identified a gap of published information given an evident need for BH services in the PACE participant population. Findings also indicate the NPA works to advance BH integration in POs with a dedicated workgroup that has produced the NPA BH Toolkit, BH training webinar series, and a site coaching program.

Conclusions

In the absence of PACE‐specific BH delivery guidelines and guidance from the federal or state level for PACE programs, BH service inclusion has been developed unevenly across POs. Assessing the landscape of BH inclusion across POs is a step toward evidence‐based and standardized inclusion of BH within the all‐inclusive care model.
Caspr1 antibodies autoimmune paranodopathy with severe tetraparesis: Potential relevance of antibody titers in monitoring treatment response
Authors: Bresciani Lorenzo , Salvalaggio Alessandro , Vegezzi Elisa , Visentin Andrea , Fortuna Andrea , Anglani Mariagiulia , Cacciavillani Mario , Masciocchi Stefano , Scaranzin Silvia , Carecchio Miryam , Martinuzzi Andrea , Gastaldi Matteo , Briani Chiara
Published: May 2023

Aim

Nodopathies and paranodopathies are autoimmune neuropathies associated with antibodies to nodal–paranodal antigens (neurofascin 140/186 and 155, contactin‐1, contactin‐associated protein 1 [Caspr1]) characterized by peculiar clinical features, poor response to standard immunotherapies (e.g., intravenous immunoglobulins, IVIg). Improvement after anti‐CD20 monoclonal antibody therapy has been reported. Data on Caspr1 antibodies pathogenicity are still preliminary, and longitudinal titers have been poorly described.

Methods

We report on a young woman who developed a disabling neuropathy with antibodies to the Caspr1/contactin‐1 complex showing a dramatic improvement after rituximab therapy, mirrored by the decrease of antibody titers.

Results

A 26‐year‐old woman presented with ataxic‐stepping gait, severe motor weakness at four limbs, and low frequency postural tremor. For neurophysiological evidence of demyelinating neuropathy, she was diagnosed with chronic inflammatory demyelinating polyradiculoneuropathy and treated with IVIg without benefit. MRI showed symmetrical hypertrophy and marked signal hyperintensity of brachial and lumbosacral plexi. Cerebrospinal fluid showed 710 mg/dL protein. Despite intravenous methylprednisolone, the patient progressively worsened, and became wheelchair‐bound. Antibodies to nodal–paranodal antigens were searched for by ELISA and cell‐based assay. Anticontactin/Caspr1 IgG4 antibodies resulted positive. The patient underwent rituximab therapy with slow progressive improvement that mirrored the antibodies titer, measured throughout the disease course.

Conclusions

Our patient had a severe progressive course with early disability and axonal damage, and slow recovery starting only a few months after antibody‐depleting therapy. The close correlation between titer, disability, and treatment, supports the pathogenicity of Caspr1 antibodies, and suggest that their longitudinal evaluation might provide a potential biomarker to evaluate treatment response.
Incidence of and risk factors for local complications of peripheral venous catheters in patients older than 70 years: Empirical research quantitative
Authors: Gras Emmanuelle , Jean Alexia , Rocher Vincent , Tran Yohann , Katsahian Sandrine , Jouclas Diane , Dano Catherine , Cedile Johane , Manar Dalinda , Kassis Chikhani Najiby , Le Guen Julien , Patas D’illiers Clémence , Lebeaux David
Published: May 2023

Aims

To assess the incidence density of local complications of peripheral venous catheters in patients aged 70 years and older, to identify risk factors for local complications of peripheral venous catheters, to describe microbiological epidemiology and to assess the impact of complications on patient outcomes.

Design

Prospective, observational, single‐centre study.

Methods

Patients 70 years and older admitted to the geriatric department of a teaching hospital in France between December 2019 and May 2020 were considered for inclusion if they had a peripheral venous catheter during their stay. Nurses checked the catheter insertion site three times a day for local complications; physicians ensured the follow‐up of complications. The STROBE checklist was used in this prospective observational study.

Results

A total of 322 patients were included, with 849 peripheral venous catheters; the median age was 88 years and 182 (56.5%) were women. The incidence density of local complications was 50.5/1000 peripheral venous catheter‐days. Risk factors for local complications on multivariate analysis were dressing replacement (OR 1.18), furosemide (OR 1.11) and vancomycin (OR 1.60) infusion, urinary continence (OR 1.09) and hematoma at the catheter insertion site (OR 1.15). Thirteen cellulitis and three abscesses were diagnosed. Occurrence of a local complication was associated with a 3‐day increased duration of hospital stay (17 vs. 14 days).

Conclusion

Risk factors for peripheral venous catheter local complications include urinary continence, furosemide or vancomycin infusion, hematoma at the peripheral venous catheter insertion site or dressing replacement.

Implication for the Patient Care

Closer clinical monitoring may help reduce the occurrence of local peripheral venous catheters complication in patients 70 years and older.

Relevance to Clinical Practice

Patients at greater risk of peripheral venous catheter local complications deserve closer clinical monitoring or improved preventive measures, which may be beneficial to reduce the length of hospital stay.

No Patient or Public Contribution

The study was designed to describe risk factors for local complications of peripheral venous catheters in order to reinforce surveillance in this specific population by nurses and medical staffs. Patients had their peripheral venous catheter insertion site checked thrice a day by the nurse in charge as part of usual care. They, as service users, caregivers or members of the public, were not solicited for data collection, analysis, interpretation or preparation of the manuscript.
Fifty years of development of neuroscientific insights into oro‐facial pain and its control
Authors: Sessle Barry J.
Published: May 2023

When the Journal of Oral Rehabilitation was established in 1973, there was very limited understanding of the mechanisms underlying neurally based functions, including those unique to the face, mouth and jaws (e.g. dental pain, taste, chewing, swallowing and salivation). Since that time, technological and other advances have led to new insights into the structure, connectivity and function of cranial nerves and areas of the central nervous system (CNS) involved in oro‐facial functions and disorders or related functions (e.g. cognition, emotion, stress, consciousness, sleep, learning and memory). This review focuses on the advances in understanding of the neural basis of oro‐facial pain and its control over the past five decades. The review first briefly considers how oro‐facial pain conditions are now classified, diagnosed and managed. It then outlines novel insights that have been gained over this period through neuroscience research into the neural basis of these oro‐facial pain conditions and the clinical relevance to these insights to the diagnosis and management of these conditions. The review also identifies promising research directions and gaps in knowledge that still need to be addressed to improve the understanding, diagnosis and management of oro‐facial pain conditions.
Predicting oral cancer survival—Development and validation of an Asia‐Pacific nomogram
Authors: Wang Weilan , Zhang Qingpeng , Thomson Peter , Sharma Dileep , Ramamurthy Poornima , Choi Siu‐Wai
Published: May 2023

Background

Nomograms are graphical calculating devices that predict response to treatment during cancer management. Oral squamous cell carcinoma (OSCC) is a lethal and deforming disease of rising incidence and global significance. The aim of this study was to develop a nomogram to predict individualized OSCC survival using a population‐based dataset obtained from Queensland, Australia and externally validated using a cohort of OSCC patients treated in Hong Kong.

Methods

Clinico‐pathological data for newly diagnosed OSCC patients, including age, sex, tumour site and grading, were accessed retrospectively from the Queensland Cancer Registry (QCR) in Australia and the Clinical Data Analysis and Reporting System (CDARS) in Hong Kong. Multivariate Cox proportional hazard regression was used to construct overall survival (OS) and cancer‐specific survival (CSS) prediction models. Nomograms were internally validated using 10‐fold cross validation, and externally validated against the Hong Kong dataset.

Results

Data from 9885 OSCC patients in Queensland and 465 patients from Hong Kong were analysed. All clinico‐pathological variables significantly influenced survival outcomes. Nomogram calibration curves demonstrated excellent agreement between predicted and actual probability for Queensland patients. External validation in the Hong Kong population demonstrated slightly poorer nomogram performance, but predictive power remained strong.

Conclusion

Based upon readily available data documenting patient demographic and clinico‐pathological variables, predictive nomograms offer pragmatic aid to clinicians in individualized treatment planning and prognosis assessment in contemporary OSCC management.
Dimensions of Identity Development Scale: Confirmatory factor analysis, gender invariance, and external validity of the Persian version
Authors: Salehi Yegaei Pardis , Achenbach Thomas M. , Trejos‐Castillo Elizabeth , Mastrotheodoros Stefanos , Izanloo Balal , Habibi Asgarabad Mojtaba
Published: May 2023

The present study was conducted to examine the psychometric properties and gender invariance of the Iranian version of the Dimensions of Identity Development Scale (DIDS). A total of 1453 adolescents (50.8% female; 14–18 years old, mean = 15.48) participated in a cross‐sectional study and completed the DIDS and the Youth Self‐Report of behavior problems. The Confirmatory Factor Analysis supported the six‐factor model of the DIDS, echoing past studies showing the original 5th factor (Exploration in Depth) being divided into Exploration in Depth and Reconsidering the Commitment. The invariance testing showed comparable measurement properties of the DIDS across males and females (strict measurement invariance). Further, behavior problems were associated positively with Ruminative Exploration and negatively with Commitment Making, Identification with Commitments, Exploration in Depth, and Reconsideration of Commitments, whereas the opposite was true for academic performance. A six‐factor DIDS was shown to be a valid and reliable measure for the assessment of identity development dimensions among Iranian adolescents. Future studies in the Iranian context evaluating the identity clusters derived from identity dimensions and their gender differences are warranted.
Loss of body weight and lean mass in long‐stay, hospitalized canine patients
Authors: Leung Y. Becca , Cave Nick , Wester Timothy J.
Published: May 2023

A high prevalence of malnutrition occurs in human hospitals and has been associated with detrimental consequences. By comparison, much less is known in hospitalized veterinary patients. The aims of this study were to evaluate the prevalence of malnutrition and body composition changes in long‐stay hospitalised patients using an isotopic dilution technique. An additional objective was to compare the changes in composition with commonly used methods measuring body fat and lean mass. The dogs consumed on average 77.5% of their estimated resting energy requirements during their stay. The majority (78.3%) of dogs lost body weight, of which a greater proportion was lean mass (61.8%) than fat mass (FM) (38.2%). There was a moderate correlation between body condition score and percentage FM measured at admission (Kendall'sτ = 0.51;p = 0.002), and at discharge (Kendall'sτ = 0.55;p = 0.001). However, there was no correlation between muscle condition score and fat‐free mass at either admission or discharge (p > 0.1). Duration of stay was positively associated with loss of body weight (p < 0.001), but was not associated with changes in either lean or FM expressed as a percentage of body weight or in absolute terms (p > 0.1), which was presumed to be explained by small sample size and variation. Food intake was not found to a significant factor for lean or FM loss (p > 0.1). These findings indicate that weight loss is common in hospitalized canine patients, which is not explained by simple under‐eating. Other factors such as inflammation and inactivity should be evaluated in future studies to determine their role in influencing muscle and FM changes in hospitalized canine patients.
What Is Haydn Doing in a John Field Nocturne?
Authors: SUTCLIFFE W. DEAN
Published: May 2023

The middle section of John Field's Nocturne No. 13 in D minor, published in 1834, towards the end of the composer's life, begins with what appears to be a quotation from the start of the finale of Haydn's Quartet in E♭ major Op. 76 No. 6. Apart from the transposition of Haydn's theme to D major and the use of a different medium, the respective passages are all but identical. This unlikely correspondence is all but unknown and has never been critically discussed. I show that the quotation is no isolated event; indeed, it turns out to be integral to Field's conception of the entire nocturne. The first section, at least in retrospect, can be heard to work with the same shapes, though in the minor mode, before they are transformed by their major‐mode guise in the followingpiù motosection. I consider the affective implications of the quotation in the context of the whole work as well as its possible significance for Field himself and his milieu. Beyond those considerations, the quotation is significant for what it tells us about the reception of Haydn in a supposedly hostile or indifferent nineteenth century.
A false dichotomy in denying explanatoriness any role in confirmation
Authors: Lange Marc
Published: May 2023

Roche and Sober (2013; 2014; 2017; 2019) have offered an important new argument that explanatoriness lacks confirmatory significance. My aim in this paper is not only to contend that their argument fails to show that in confirmation ‘there is nothing special about explanatoriness’ (Roche & Sober, 2017: 589), but also to reveal what is special confirmationwise about explanatoriness. I will argue that much of the heavy work in Roche and Sober's argument is done by the dichotomy into which they carve up the philosophical options: either explanatory considerations per se are confirmatorily relevant or they acquire whatever confirmatory significance they may possess only by way of background beliefs and so no differently from non‐explanatory considerations. I will argue that this is a false dichotomy: Explanatoriness per se can have confirmatory relevance even while explanatory considerations acquire their confirmatory relevance only through background opinions. Furthermore, there is ‘something special’ about the background opinions concerning explanations that allow explanatoriness in itself to have confirmatory impact. Unlike other sorts of background, having some background opinions expressly about explanations is indispensable to being an observer at all.