bluuebunny/crossref_metadata_2025 huggingface dataset:
An investigation of the effects of melatonin administration on biochemical parameters in rats with experimental cartilage damage
Authors: Yıldız Kadri , Tahiroğlu Veysel , Boy Fatih , Koç Seher , Yıldız Vahit , Demirel Esra
Published: April 2021

Objective:  This study was intended to show the effects of melatonin (MEL) in the treatment of cartilage damage in a rat model as a novel field of application.

Materials and Methods: Male Sprague Dawley rats aged 3-4 months were assigned into four groups of six rats each. Group I represented the sham group. In groups 2, 3, and 4, the right knee medial meniscus was surgically destabilized. MEL was administered to groups 3 and 4 twice a week at dosages of 0.4 μg/ml and 4 μg/ml, respectively. The application continued for four weeks. Histological examinations, imaging studies [computed tomography and magnetic resonance imaging], and biochemical tests [cartilage and bone turnover markers (COMP and CTX-I)] were performed.

Results: The application of MEL initiated regeneration in the damaged areas. However, cartilage repair was not observed in areas with experimental cartilage damage without MEL application. MEL-treated rats had higher T2 scores compared to Group 1 in the median femoral condyle at the 12th week (p<0.05). Serum COMP and CTX-I levels at 12 weeks were significantly higher in Group 2 compared to Group 1 (p<0.05). Serum COMP and CTX-I levels at 12 weeks were lower in groups 3 and 4, but were also significantly higher than in Group 1 (p<0.05).

Conclusion: We recommend MEL therapy for diseases related to cartilage damage. MEL seems to exert its therapeutic effect on cartilage damage through its antioxidant properties.
Basal Cell Nevus Syndrome caused by a new splice site mutation in PTCH1
Authors: Nutsathapana Nattaya , Bunnag Thareena , Chaowalit Prapaipit , Supsrisunjai Chavalit
Published: April 2021

Basal cell nevus syndrome is a rare inherited autosomal dominant syndrome characterized by developmental defects and tumor predisposition. There are more than 400 reported PTCH1 mutations, including frameshift, nonsense, missense, deletions, duplications, and splicing mutations. We report a 68-year-old Thai female presenting with multiple basal cell carcinoma scattered on the face and upper back and palmoplantar pits. Molecular diagnosis showed a novel heterozygous mutation in the splice site region c.746+1_746+4delGTAA, localized within the splice donor after exon 5 of PTCH1. Although the clinical manifestations are characteristic, this report adds another splice site mutation to the genotypic variation of BCNS patients and also highlights the importance of a multidisciplinary approach in the management of BCNS patients.
The Fallacy of Contract in Sexual Slavery: A Response to Ramseyer's "Contracting for Sex in the Pacific War"
Authors: Lee Yong-Shik , Saito Natsu , Todres Jonathan
Published: April 2021

Over seven decades have passed since the end of the Second World War, but the trauma from the cruelest war in human history continues today, perpetuated by denial of responsibility for the war crimes committed and unjust attempts to rewrite history at the expense of dignity, life, and justice for the victims of the most serious human rights violations. The latest such attempt is a troubling recharacterization of the sexual slavery enforced by Japan during the Second World War as a legitimate contractual arrangement. A recent paper authored by J. Mark Ramseyer, entitled “Contracting for Sex in the Pacific War,” mischaracterizes forced sexual slavery as a contractual process by which the victims freely participated in prostitution in return for a substantial reward, denying the responsibility of the Japanese government and its military for the atrocious human rights violations committed. The argument of that paper is flawed and disregards a breath of evidence, including numerous testimonies of survivors, and the findings of scholars, NGOs, and intergovernmental organizations, including the United Nations Human Rights Commission, that the victims were coerced, deceived, or otherwise manipulated into sexual servitude with the direct or indirect involvement of the Japanese government or the military, as admitted by Japan in the 1993 Kono Statement. This article discusses the critical flaws in the arguments advanced by the paper, the traumatic impact of such arguments on survivors of these war crimes, and the broader implications of these (and other similar) justifications for sexual exploitation.
Al-Sajā’ir wa shabakat al-‘ulamā’ al-Miṣrīyīn fī Nusantara: Dirāsah fī makhṭūṭ “Bāb fī bayan shurb al-dukhān”
Authors: Rohmana Jajang A.
Published: April 2021

This study reveals on fatwas concerning cigarettes in the Archipelago in the 19th century. The primary source is an Arabic manuscript from Kuningan, West Java, digitized by DREAMSEA, entitled “Bāb fī Bayān Ḥukm Shurb al-Dukhān”. It does not only use arguments from sharia, the interpretation of ulama, and health reasons but also refers to myths and conspiracies. This study finds that this manuscript mentions the existence of ḥaram (prohibited) and makrūh (not legally forbidden but discouraged) on cigarettes referring to two Egyptian ulama in the 17th century. Through analyzing fiqh and social history, this philological study discloses the connection between its author with the Egyptian’s ulama networks as a new center for ideas of Islamic civilization aside from Haramayn. Hence, the arguments of the manuscript openly consider many aspects of sharia in responding to such a new tradition (cigarettes) in the Muslim community. This is different from similar manuscripts discussing this kind of fatwa in the 19th century which only judge as haram so that it is considered politically as a form of a critique against the colonial tobacco business policies.
Relationship Between Husband’s Support And Mother’s Attitude To Exclusive Breastfeeding For 6 Months
Authors: Indana Zulfa Fariza , Sutrisminah Emi , Rahmawati K. Meilia
Published: April 2021

Introduction: Breastfeeding is the responsibility of a woman who has a baby. The decision of the Indonesian Ministry of Health assign exclusive breastfeeding was given for 6 months and continues until 2 years old. Until now in Indonesia there are still many women who have not given exclusive breastfeeding to their babies. The failure to give exclusive breastfeeding is caused by several factors, one of which is the husband's support and mother's attitude. Objective: To determine the relationship between husband's support and the mother's attitude to breastfeed exclusively for 6 months in the Kudu Village, Semarang City.  Methods: This was a descriptive qualitative study with an analytical study design with Cross Sectional. The study populations was 116 pregnant womens, the research sample was 32 third trimester pregnant womens. The sampling technique in this study uses total sampling. Results: Fisher's Exact Test analysis results on the two variables of this study obtained p value = 0.018 where p value <0.05 then Ha is accepted, which means there is a relationship between the husband's support variable and the mother's attitude to breastfeed exclusively for 6 months. Conclusion: The mayority of respondents recived husband’s support and had a good attitude for exclusive breastfeeding for 6 months.
Long term Depot Medroxy Progesterone Asetate (DMPA) Injectable Increase Changes in Lipid Profiles of DMPA Injection Contraceptive Acceptors
Authors: Handayani Ririn
Published: April 2021

DMPA injectable contraceptives can cause changes in lipoprotein metabolism. Long term use of DMPA increases triglyceride levels, total cholesterol and LDL and decreases HDL levels. So, it can be concluded that DMPA can cause changes in lipid metabolism which can increase the risk of cardiovascular disease. Changes in fat metabolism occur due to the influence of the hormonal progesterone, which causes disruption of the balance of the lipid profile in the body. The purpose of this study was to determine the effect of using Depo Medroxy Progeserone Acetate injection on the lipid profile of three months injection family planning acceptors based on the duration of use.This research is an analytic observational study with a cross sectional approach, the population in this study were all DMPA family planning acceptors in the work area of ​​the Banjar Sengon Community Health Center, the sampling technique used was total sampling with a sample size of 30. Examination of the lipid profile was carried out by taking blood samples and then measuring them. lipid profile using the enzymatic colorimetric method (cholesterol oxidase method / CHOD PAP). The measurement results obtained were then analyzed using the Independent T test. The results of the T test analysis showed that the P value for cholesterol levels was 0.016 (P <0.05); The p value for triglyceride levels was 0.004 (P <0.05); The p value for HDL levels was 0.046 (P <0.05); The p value for LDL levels was 0.004 (P <0.05).From these data it can be concluded that there is a significant difference in the average levels of cholesterol, triglycerides, HDL, LDL between respondents with a duration of use <3 years and> 3 years. Respondents are expected to carry out routine lipid profile checks to detect early detection of possible abnormalities in lipid profiles that can lead to the risk of heart defects and stroke.
Effect Of Bioinsecticide Granule Mixture Of Sugar Apple Seed (Annonae Squamosa) And Betel Leaf (Piper Betle) On Morphology Of Eggs Aedes Aegypti
Authors: Novitasari Firdha , Wahyuni Dwi , Sulistyaningsih Erma
Published: April 2021

Introduction: Dengue hemorrhagic fever (DHF) is an important public health problem in Indonesia because its morbidity and mortality are quite high. Prevention by vector control methods with chemical insecticides adversely affects the environment. Research on granular bioinsectide mixture of betel leaf extract and sugar apple seeds against Aedes aegypti is expected to be used to break the chain of Aedes aegypti mosquitoes starting  from the juvenile stage  (eggs) as an effort to control the vector population naturally. Objective: This study aims to analyze the effect of granule bioinsecticide mixture of sugar apple seed extract and betel leaf on changes in the morphology of Aedes aegypti eggs. Methods: This study is a true-experimental study with a Post test Only Control Group Design design. The treatment group will be given a granular bioinsecticide, a mixture of sugar apple seed extract and betel leaf, positive control will be given abate while negative control will be given aquades. Each group uses 25 eggs with 3 repetitions. On day 3, all eggs will be observed using a stereo microscope to determine morphological changes. The data obtained will be analyzed using ordinal regression test. Results: the ordinal regression test got the value of ρ in the Wald test between (0.012 - 0.955)> α = 0.01. Conclusion: there is no effect of mixed granules of betel leaf and sugar apple seeds on the mortality of Aedes aegypti eggs. Further research is needed on new formulations using other natural ingredients to increase the effect of ovicides on Aedes aegypti.
Descriptive Study Of Factors Affecting Nurses Caring Behavior In Baladhika Husada Jember Hospital
Authors: Efrizal amrullah Akhmad , Elliya Astutik Emi , Djalil Ahbab Achmad
Published: April 2021

Introduction: Caring behavior is very important for nurses to have because it illustrates the quality of nursing care, especially for nurses who work in inpatient units. There are three factors that can influence the level of caring behavior, namely individual, psychological and organizational factors. Meanwhile, caring behavior is assessed from Knowing, Being With, Doing For, Enabling, and Maintaining Belief.  Objective: To describe the factors that influence the caring behavior of nurses in Baladhika Husada Jember Hospital.  Methods: Nonexperimental design with descriptive type, in which the approach was cross sectional, carried out for 1 month and involved 62 respondents.  Results: 47 respondents stated that the three factors above had an influence on caring behavior and 15 respondents stated that it had no effect, while the caring behavior of respondents in the good category was 58 people and 4 people were not good. Analysis of data using the One-Sample Binominal test at alpha (α) = 0.05, has the p-value = 0.000, which illustrates the difference between the factors that influence caring behavior towards nurses caring behavior.  Conclusion: The factors that influence caring behavior are directly proportional to caring behavior, meaning the better factors that influence caring behavior, the better nurses caring behavior level. Maintaining and improving caring behavior requires good effort and cooperation between the hospital manager which is the place for health services and nurses as nursing care providers.
Word frequency, Range and Lexical diversity: Picking out Changes in Lexical Proficiency among University Learners in an EFL Context
Authors: Ait Hammou Brahim , Larouz Mohammed , Fagroud Mustapha
Published: April 2021

While frequency of occurrence and lexical diversity are common measures of lexical proficiency, very few studies have examined range along with these two other lexical indices, especially in EFL contexts. Using a sample of 529 undergraduate EFL learners’ essays, the present study examined the development of three indices of lexical proficiency (word frequency, range and lexical diversity) across 3 different proficiency levels. No similar study has been conducted so far in the Moroccan context, which makes this study a valuable contribution to a better understanding of university learners’ productive lexical knowledge. Unexpectedly, although frequency is an established measure which can successfully show differences in learners’ proficiency, the results of this study indicate that at the productive level, the range of content words and lexical diversity might better reflect differences among learners of different proficiency levels. While word frequency was stable among the three groups, indices of range and lexical diversity reflected better lexical knowledge in higher proficiency levels. We concluded that in EFL contexts, range and diversity might be better measures of proficiency. This suggests that there should be more focus on developing these two aspects in EFL classes.
Impact of Integrating Task-Based Learning and Functional Approach to Empower Learners’ Communicative Competence
Authors: Nguyen Tri , Dao Trang Xuan Phuong
Published: April 2021

Enhancing EFL learners’ communicative competence is a time-taking process to reach certain levels of interacting with different communication participants. However, in the tertiary education in Vietnam, traditional teaching approach with the task-based learning does not thoroughly focus on the language use but on the strategies to perform the tasks. Hence, the functional approach has been applied to boost learners’ awareness of their language delivery thanks to communicative functions and notions. The new mode of teaching concentrates on what communication participants desire to convey and why they make use of those speech acts. This paper aimed to explore the impact of the integration of task-based learning and the functional approach, and learners’ perspective towards the implementation of such approach combination. With the application of the mixed method of qualitative and quantitative approaches, the data were collected via a pre-test and a post-test, survey, and 32 interviews with the participation of 100 students whose major is Business Administration at a university. The findings reveal that adding the functional approach to the existing teaching method could enhance students’ overall speaking competence, especially their fluency and discourse management. Additionally, the application of the functional approach received positive feedback from the learners.
Evolution: A Theory in Crisis Revisited (Part One of Three)
Authors: Denton Michael
Published: April 2021

Despite massive discoveries in many areas of biology, orthodox evolutionary theory is no better able to explain the origins of key taxa-defining innovations than it was 30 years ago. Biochemist Michael Denton reappraises his 1985 book Evolution: A Theory in Crisis in light of these discoveries.
The Beginning of the Universe
Authors: Vilenkin Alexander
Published: April 2021

Despite the perplexing questions associated with the universe having a beginning, the BGV theorem shows it must have had one. Alexander Vilenkin describes the theory of quantum creation, and why it means that the universe both could have a beginning and be uncaused.
The Genus Homo
Authors: Tattersall Ian
Published: April 2021

The history of the hominid family, like that of other mammals, means diversification, competition, and, sometimes, extinction. Paleoanthropologist Ian Tattersall explains why we need a phylogeny-based definition of the genus Homo that includes our species Homo sapiens, and why we don’t have one.
The Difference It Makes
Authors: Scialabba George
Published: April 2021

Agency, autonomy, and artificial intelligence. George Scialabba reviews The Restless Clock: A History of the Centuries-Long Argument over What Makes Living Things Tick by Jessica Riskin.
The Obstetrical Dilemma
Authors: Nelson Chase
Published: April 2021

An evolutionary tradeoff: bipedalism requires a narrow pelvis, but larger brains require wider birth canals. Hence early birth. Chase Nelson analyzes a new theory in the debate over human neonate helplessness. Helplessness itself exerts a selective force; it requires intelligent parents.
Who Is It Meant For?
Authors: Salaburu Pello , Uriagereka Juan , Berlinski David
Published: April 2021

Who is the intended audience of David Berlinski and Juan Uriagereka’s essay “Recovery of Case”?
Categories: From Zero to Infinity
Authors: Schapira Pierre
Published: April 2021

Set theory, category theory, and topology. Pierre Schapira explores the concept of identity within category theory, and what it means for the properties to be satisfied only up to homotopy.
Pengaruh Penggunaan Metode Ceramah dan Media Slide Presentasi terhadap Motivasi Belajar Mahasiswa
Authors: Saputra Yudha Nata , Mendrofa Yuspita Sari Dewi
Published: April 2021

Tujuan penelitian yaitu untuk menganalisa pengaruh variabel penggunaan metode ceramah dan media slide presentasi terhadap motivasi belajar mahasiswa baik sendiri-sendiri maupun bersama-sama. Metode penelitian yang digunakan dalam penelitian ini adalah pendekatan kuantitatif, dengan menggunakan analisa regresi linier sederhana dan analisa regresi linier ganda. Hasil penelitian menemukan bahwa terdapat pengaruh yang signifikan variabel penggunaan metode ceramah (X1) terhadap variabel motivasi belajar mahasiswa (Y) sebesar 21.25% dengan koefisien korelasi sebesar 0.46 yang menunjukkan adanya hubungan positif yang cukup, artinya dengan semakin baik penggunaan metode ceramah maka motivasi belajar siswa akan semakin tinggi. Terdapat pengaruh variabel penggunaan media slide presentasi (X2) terhadap motivasi belajar mahasiswa (Y) sebesar 17.72% dengan koefisien korelasi sebesar 0.42 yang menunjukkan adanya hubungan positif yang cukup, artinya dengan semakin baik penggunaan media slide presentasi maka motivasi belajar siswa akan semakin tinggi. Terdapat pengaruh simultan yang signifikan variabel penggunaan metode ceramah (X1), penggunaan media slide presentasi (X2) terhadap variabel motivasi belajar mahasiswa (Y) sebesar 27.82% artinya dengan semakin baiknya penggunaan metode ceramah, media slide presentasi maka motivasi belajar mahasiswa akan semakin tinggi.
Resolusi Konflik Pembangunan Gereja Baptis Indonesia di Tlogosari Semarang
Authors: Wijayanto Wahyudi Sri
Published: April 2021

Tlogosari Kulon adalah salah satu kelurahan yang berada di Kecamatan Pedurungan Kota Semarang, mayoritas penduduknya adalah beragama Islam. Pada tanggal 1 Agustus 2019 terjadi konflik penghentian pembangunan Gereja Baptis Indonesia di Tlogosari Semarang. Tujuan dari penelitian yaitu untuk mencari penyebab konflik pembangunan Gereja Baptis Indonesia Tlogosari di Semarang dan bagaimana resolusi konflik pembangunan Gereja Baptis Indonesia Tlogosari Semarang. Metode penelitian yang dipakai adalah kualitatif lapangan (fieldresearch). Hasil penelitian yang di dapat yaitu pertama, penyebab konflik Pembangunan Gereja Baptis Indonesia di Tlogosari adalah warga Malangsari RT 06/RW 07 merasa kecewa karena dalam memperoleh Izin Mendirikan Bangunan (IMB) pihak Gereja memakai cara curang yaitu dengan penipuan tanda tangan warga. Selain itu juga warga khawatir jika ada Gereja Baptis Indonesia di tempat itu keimanan mereka menjadi terganggu. Kedua, resolusi konflik yang dilakukan oleh pemerintah kota adalah melalui mediasi yang kemudian dipimpin oleh Komnas HAM (Komisi Nasional Hak Asasi Manusia) sehingga Gereja diizinkan kembali membangun. Terlihat secara hukum pihak Gereja sudah dapat membangun Gereja tetapi secara sosial kemasyarakatan belum terlihat suatu damai positif.
NEW GENERALIZATIONS OF HESITANT AND INTERVAL-VALUED FUZZY IDEALS OF SEMIGROUPS
Authors: Jittburus U. , Julatha P.
Published: April 2021

In this paper, we introduce the notion of $\sup$-hesitant fuzzy ideals of semigroups, which is the general notion of hesitant fuzzy ideals and interval-valued fuzzy ideals. In addition, $\sup$-hesitant fuzzy ideals are characterized in terms of sets, fuzzy sets, hesitant fuzzy sets and interval-valued fuzzy sets. Finally, $\sup$-hesitant fuzzy translations and $\sup$-hesitant fuzzy extensions of $\sup$-hesitant fuzzy ideals of semigoups are discussed, and their relations are investigated.
The impact of molecular tumor profiling on the design strategies for targeting myeloid leukemia and EGFR/CD44-positive solid tumors
Authors: Geskovski Nikola , Matevska-Geshkovska Nadica , Dimchevska Sazdovska Simona , Glavas Dodov Marija , Mladenovska Kristina , Goracinova Katerina
Published: April 2021

Nanomedicine has emerged as a novel cancer treatment and diagnostic modality, whose design constantly evolves towards increasing the safety and efficacy of the chemotherapeutic and diagnostic protocols. Molecular diagnostics, which create a great amount of data related to the unique molecular signatures of each tumor subtype, have emerged as an important tool for detailed profiling of tumors. They provide an opportunity to develop targeting agents for early detection and diagnosis, and to select the most effective combinatorial treatment options. Alongside, the design of the nanoscale carriers needs to cope with novel trends of molecular screening. Also, multiple targeting ligands needed for robust and specific interactions with the targeted cell populations have to be introduced, which should result in substantial improvements in safety and efficacy of the cancer treatment. This article will focus on novel design strategies for nanoscale drug delivery systems, based on the unique molecular signatures of myeloid leukemia and EGFR/CD44-positive solid tumors, and the impact of novel discoveries in molecular tumor profiles on future chemotherapeutic protocols.
THE EFFECT OF ENTREPRENEURSHIP ORIENTATION AND MARKET ORIENTATION ON MARKETING PERFORMANCE OF FURNITURE HOME INDUSTRY IN SAWAHAN DISTRICT
Authors: Sudarmadji Chatarina Felisia , Sidharta Helena , Wiryakusuma I Gusti Bagus Yosia
Published: April 2021

This study analyzes the effect of entrepreneurial orientation and market orientation on the marketing performance of furniture home industry in Sawahan District. The objectives of this research are to: (1) determine the effect of entrepreneurial orientation on marketing performance (2) determine the effect of market orientation on marketing performance. The population in this study were 158 furniture home industry businesses in Sawahan District, Surabaya. The number of samples taken is 113 respondents which was determined using the Slovin formula. By using a quantitative research approach, the sampling technique used in this study used a random sampling method. Source of data obtained in this study is through the process of distributing questionnaires to 113 respondents in the home furniture industry in the District of Sawahan. The analytical tool used was SPSS 22. The results of the research obtained are that (1) entrepreneurial orientation do not significantly influence the marketing performance of furniture home industry in Sawahan District (2) Market orientation do not significantly influence the marketing performance of furniture home industry in Sawahan District. From the results of the research, business actors can begin to implement entrepreneurial orientation and market orientation through real practice. External encouragement is needed by businesses through extension activities and intensive training given by the government to mentally equip and provide knowledge so the furniture home industry business owners in Sawahan District can maintain the sustainability of their businesses.
Building Canvas Strategy for Integrated Tourism Area and Benchmark: Blue Ocean Strategy Approach
Authors: Utami Christina Whidya , Susanto Hendro , Septina Fanny , Pujirahayu Yoseva Maria , Razak Muhammad Nurdin
Published: April 2021

This research aims to identify tourism factors that should be eliminate, reduce, raise, and create (ERRC) to indicate the characteristics of Blue Ocean Strategy (BOS) in order to revitalize the development of Kenjeran tourism area, Surabaya by taking into account aspects of education, local economic improvement, and environmental conservation. The research methodology is based on descriptive approach through analyzing the strength, weakness, opportunities, and threats (SWOT) to find the key success factor, the industry benchmarks, and the tourism market agents in order to understand the ERRC and to set a canvas strategy. The result shows that Revitalization is done by; Eliminating Aspect of Sustainable Environment including environmental pollution, abrasion, and unregulated zone. Reducing Aspect of Attractions, including: a shift in local culture and focus on shopping area. Factors that should be raise is Aspect of Accessibility and Empowerment, including: tourism facilities, and community capacity development. whereasWhereas elements that should be created are included in Aspect of Tourism Industry, including pattern of partnership and community development. The novelties of this research is using Blue Ocean Strategy via a 4-step approach: Eliminate, Reduce, Raise, and Create (ERRC) to revitalize an integrated tourist area.

Keywords: Eliminate; Reduce; Raise and Create (ERRC); canvas strategy; Blue Ocean Strategy.
Application of an Analytic Hierarchy Process to Select the Level of a Cyber Resilient Capability Maturity Model in Digital Supply Chain Systems
Authors: Uraipan Naris , Praneetpolgrang Prasong , Manisri Tharini
Published: April 2021

Cyber resilient is the ability to prepare for, respond to and recover from cyber attacks. Cyber resilient has emerged over the past few years because traditional cybersecurity measures are no longer enough to protect organizations from the spate of persistent attacks. It helps an organization protect against cyber risks, defend against and limit the severity of attacks, and ensure its continued survival despite an attack.The cyber resilient capability maturity model is a very important element within an effective in digital supply chain. The maturity model has 6 components: identify, protect, detect, respond, recover and continuity which affect the cybersecurity of the organization. To measure the maturity level needs a holistic approach. Therefore, the analytic hierarchy process (AHP) approach which allows both multi-criteria and simultaneous evaluation. Generally, the factors affecting cyber resilient in digital supply chain have non-physical structures. Therefore, the real problem can be represented in a better way by using fuzzy numbers instead of numbers to evaluate these factors. In this study, a fuzzy AHP approach is proposed to determine the cyber resilient capability maturity level in digital supply chain. The proposed method is applied in a real SMEs company. In the application, factors causing are weighted with triangular fuzzy numbers in pairwise comparisons. The result indicate that the weight factors from comparing the relationship of all factors put the importance of identify factors first, followed by protect, detect, respond, recover and continuity respectively.
Posterior Superior Alveoler Arter Konumunun Cinsiyet ile İlişkisi: Retrospektif Analiz
Authors: ÖZER Ahmet Murat , BULUT Ayşe
Published: April 2021

Amaç: Maksiller sinüs anatomisi hakkında yeterli bilgi, perioperatif veya postoperatif komplikasyonlardan kaçınmak için gereklidir. Bu çalışmanın amacı, konik ışınlı bilgisayarlı tomografi (KIBT) ile posterior superior alveolar arterin (PSAA) prevalansını, çapını, yerini ve maksiller sinüs tabanı ve alveolar kret ile ilişkisini belirlemektir.Yöntem: Konik Işınlı Bilgisayarlı Tomografi görüntülemesi yapılmış 50 hastanın (100 maksiller sinüs) maksiller sinüsteki PSAA konumu ve çapları ile PSAA’nın lateral duvardaki alt noktası ile sinüs tabanı ve kret tepesi arasındaki mesafelerin cinsiyet ile ilişkisi retrospektif olarak değerlendirilmiştir. Tüm veriler SPSS versiyon 22.0 programı kullanılarak analiz edilmiştir. Sonuçlar p<0,05 için istatistiksel olarak anlamlı kabul edilmiştir.Bulgular: PSAA, KIBT taramalarının %100'ünde tespit edilmiştir. Arterin yerleşim yeri ile cinsiyet arasında istatistiksel olarak anlamlı fark bulunmuştur (p=0,005). PSAA'nın kadınlarda %56, erkeklerde ise %34 oranında sinüs membranının altında yerleştiği saptanmıştır. PSAA'nın lateral sinüs duvarının dış korteksinde yerleşimi ise erkeklerde kadınlara oranla 10 kat daha fazla bulunmuştur. Ortalama PSAA çapı 1,07 mm olarak ölçülmüştür. PSAA’nın alt sınırı ile sinüs tabanı arasında dik olarak ölçülen ortalama mesafe 8,30±4,17 mm, oblik olarak ölçülen ortalama mesafe 9,26±4,34 mm idi. PSAA’nın alt sınırı ile kret tepesi arasında dik olarak yapılan ölçümlerdeki ortalama mesafe 16,66±5,17 mm, oblik olarak ölçülen ortalama mesafe ise 18,36±4,84 mm olarak bulunmuştur.Sonuç: Bu çalışmadan elde edilen bulgular, PSAA konumu ve PSAA ile maksiller sinüs tabanı arasındaki mesafenin cinsiyete göre farklılık gösterebileceğini düşündürmüştür. Bu yönlerden KIBT'lerin preoperatif değerlendirilmesi tedavi planı ve başarısı açısından oldukça önemlidir.
Broken into Pieces: ATLAS and Aliqa Uma as One Single Stream
Authors: Li Ting S. , Koposov Sergey E. , Erkal Denis , Ji Alexander P. , Shipp Nora , Pace Andrew B. , Hilmi Tariq , Kuehn Kyler , Lewis Geraint F. , Mackey Dougal , Simpson Jeffrey D. , Wan Zhen , Zucker Daniel B. , Bland-Hawthorn Joss , Cullinane Lara R. , Da Costa Gary S. , Drlica-Wagner Alex , Hattori Kohei , Martell Sarah L. , Sharma Sanjib ,   (S5 Collaboration)
Published: April 2021

We present the first spectroscopic measurements of the ATLAS and Aliqa Uma streams from the Southern Stellar Stream Spectroscopic Survey (S
5), in combination with the photometric data from the Dark Energy Survey and astrometric data from Gaia. From the coherence of spectroscopic members in radial velocity and proper motion, we find that these two systems are extremely likely to be one stream with discontinuity in morphology and density on the sky (the “kink” feature). We refer to this entire stream as the ATLAS-Aliqa Uma stream, or the AAU stream. We perform a comprehensive exploration of the effect of baryonic substructures and find that only an encounter with the Sagittarius dwarf ∼0.5 Gyr ago can create a feature similar to the observed “kink.” In addition, we also identify two gaps in the ATLAS component associated with the broadening in the stream width (the “broadening” feature). These gaps have likely been created by small mass perturbers, such as dark matter halos, as the AAU stream is the most distant cold stream known with severe variations in both the stream surface density and the stream track on the sky. With the stream track, stream distance, and kinematic information, we determine the orbit of the AAU stream and find that it has been affected by the Large Magellanic Cloud, resulting in a misalignment between the proper motion and stream track. Together with the Orphan-Chenab Stream, AAU is the second stream pair that has been found to be a single stream separated into two segments by external perturbation.
Revealing Gravitational Collapse in the Serpens G3–G6 Molecular Cloud Using Velocity Gradients
Authors: Hu Yue , Lazarian A. , Stanimirović Snežana
Published: April 2021

The relative role of turbulence, magnetic fields, and self-gravity in star formation is a subject of intensive debate. We present IRAM 30 m telescope observations of the 13CO (1–0) emission in the Serpens G3–G6 molecular cloud and apply to the data a set of statistical methods. These include the probability density functions of column density and the velocity gradients technique. We combine our data with the Planck 353 GHz polarized dust emission observations and Hershel H2 column density. We suggest that the Serpens G3–G6 south clump is undergoing a gravitational collapse. Our analysis reveals that the gravitational collapse happens at volume density n ≥ 103 cm−3. We estimate the plane-of-the-sky magnetic field strength to be approximately 120 μG using the traditional Davis–Chandrasekhar–Fermi method and 100 μG using a new technique proposed in Lazarian et al (2020). We find that the Serpens G3–G6 south clump’s total magnetic field energy significantly surpasses kinetic energy and gravitational energy. We conclude that the gravitational collapse could be successfully triggered in a supersonic and sub-Alfvénic cloud.
Primary gastric melanoma of unknown origin: a case report and short literature review
Authors: Myrou Athena , Aslanidis Theodoros , Protopapas Andreas , Psoma Elisavet , Kontosis Andreas , Koletsa Triantafyllia
Published: April 2021

Though being usually a cutaneous tumor, melanomas can occur in several extracutaneous sites. Primary mucosal melanomas are rare, and primary gastric mucosal melanomas are considered extremely rare. Compared with cutaneous and ocular melanoma, mucosal melanomas have the lowest five-year survival. High level of suspicion of such rare condition may be the only way for early detection, diagnosis and chance for successful management of similar cases. In the present report, a case of a primary gastric melanoma in a 73-year-old man is described, along with a short review of the literature
Tinea barbae profunda caused by Trichophyton rubrum – an autoinoculation from a primary Tinea pedis
Authors: Vazheva Gergana , Zisova Liliya
Published: April 2021

Tinea barbae profunda is a rare mycotic infection of the beard, caused by dermatophytic fungi. Patients with suppressed immune systems and severe comorbidities, such as diabetes mellitus, are more prone to this disease, but it could also be seen in agricultural workers and stockbreeders. The most frequent etiological agents of this infection are the zoophilic dermatophytes. But in rare cases, an infection with anthropophilic dermatophytes as Trichophyton rubrum can be observed.

We present a case of a 55-year-old patient with insulin-dependent diabetes mellitus and tinea barbae profunda, caused by Trichophyton rubrum, as a consequence of autoinoculation from concomitant Tinea pedis. The patient was treated with oral antibiotics before admission to the clinic, but with no effect due to incorrect diagnosis and lack of mycological laboratory investigations. A satisfactory therapeutic outcome was achieved after a two-month course with antimycotic medications.
Cladistic analysis of Zethus Fabricius, 1804 (Hymenoptera, Vespidae): a new subgeneric classification
Authors: Lopes Rogério Botion , Carpenter James M. , Noll Fernando Barbosa
Published: April 2021

Zethusis the largest genus in Vespidae with over 270 species. It is currently divided into four subgenera: Z. (Zethus), Z. (Zethoides), Z. (Zethusculus) and Z. (Madecazethus). While the last three are restricted to certain biogeographic areas, the first is spread through western and eastern hemispheres. Studies have shown possible phylogenetic incongruence regarding this current division and even raised the possibility of paraphyly in the genus. To evaluate this classification, morphological pasimony analyses under implied weights was carried out, examining external morphology and male genitalia. Analyses showed paraphyly of the genus under various “k” values and paraphyly of two subgenera.IschnocoeliaandCtenochilusare lowered to subgenera ofZethus. Zethus (Madecazethus) is no longer restricted to Malagasy species and now includes those of the African continent as well. Zethus (Zethastrum)subg. nov.is defined for Oriental representatives. Z. (Zethus) is subdivided into three subgenera: Z. (Zethus), Z. (Didymogastra) and Z. (Wettsteinia). Zethus (Zethusculus) and Z. (Zethoides) are monophyletic and hold their status as subgenera. Three species-groups areIncertae sedis:Z. albopictus,Z. pallidusandZ. spinosus.
Le burnout chez les gastroentérologues : résultats d’une enquête
Authors: Travers Vincent , Bonnaud Guillaume , Higuero Thierry
Published: April 2021

Introduction : Le burnout a été chiffré chez les chirurgiens en général, mais jamais chez les hépato-gastroentérologues (HGE). Notre enquête a évalué le risque de burnout et le vécu professionnel auprès d’HGE libéraux. Matériel et méthodes : Les membres du Club de Réflexion des Cabinets et Groupes d’Hépato-Gastroentérologie (CREGG) ont été invités à compléter un questionnaire sur leur vécu professionnel et un test d’inventaire de burnout de Maslach (MBI). Pour chacune des trois composantes du MBI, le burnout a été classé en faible, moyen ou élevé. Ainsi, la population était considérée en danger de burnout, à surveiller ou sans surrisque. Une analyse a tenté d’identifier des facteurs engendrant un stress élevé, et prédictifs de burnout. Résultats : Globalement, 123 HGE ont complété le MBI et 70 le questionnaire. Pour le MBI, l’épuisement émotionnel était élevé pour 25,2 %, moyen pour 22 % et faible pour 52,8 % des HGE ; la dépersonnalisation était élevée pour 26 %, moyenne pour 28,5 % et faible pour 45,5 % ; la perte d’accomplissement personnel était élevée pour 48 %, moyenne pour 28,5 % et faible pour 23,5 %. Dès lors, 40 (32,5 %) HGE étaient en danger de burnout, 49 (39,8 %) à surveiller et 34 (27,6 %) sans surrisque. Les facteurs les plus prédictifs de burnout étaient ceux vécus avant et après le travail. Les praticiens de moins de 50 ans étaient plus sujets au burnout. Le volume d’activité professionnelle n’était pas corrélé à un stress élevé. Conclusion : Seul un quart des HGE vit son exercice sereinement et près d’un tiers est en burnout. Les facteurs prédictifs de vécu avant et après le travail doivent être corrigés précocement.
Médecine intégrative et covid-19. Quel support l’homéopathie peut-elle proposer? Éléments de réponse fondés sur le témoignage d’un médecin praticien intégrant l’homéopathie à sa prescription
Authors: Payrau Bernard
Published: April 2021

Ancré dans une pratique médicale « de ville », un médecin praticien rapporte son expérience de la covid-19 et sa pratique de médecine intégrative associant la prescription de l’homéopathie en complément des options thérapeutiques classiques. L’homéopathie propose parfois des réponses plus adéquates à l’épidémie d’une maladie infectieuse inédite. Fruit d’une démarche raisonnée au sein d’une pratique médicale moderne, l’homéopathie peut offrir des options judicieuses. Et si, pour le moment, elle ne peut fournir de preuves irréfutables de son activité intrinsèque, nombreux sont les travaux y compris universitaires qui mentionnent son existence. Dans le domaine des infections des voies aériennes, un nombre non négligeable de publications relatant des travaux peut être consulté. C’est en se fondant sur ces derniers qu’ont été prescrits un certain nombre de médicaments homéopathiques pour le traitement ambulatoire précoce de la covid-19. Un choix de médicaments homéopathiques est proposé pour le traitement de la phase d’invasion virale et pour celui de l’hyperréactivité bronchique caractéristique de cette maladie. La stratégie à établir face à une épidémie telle que celle de la covid-19 doit prendre en compte de nombreux paramètres individuels, collectifs et environnementaux complexes, vis-à-vis desquels la diversité des propositions qu’offre une pratique intégrative de la médecine semble très adéquate.
L’inflammation chronique perturbe la mobilisation et la migration des cellules souches, altérant le fonctionnement de notre système naturel de réparation et de renouvellement : nouvelle approche thérapeutique complémentaire et combinée dans la prise en charge de maladies chroniques inflammatoires ?
Authors: Traynard Véronique
Published: April 2021

Comme le système respiratoire, circulatoire ou digestif, les cellules souches représentent notre système naturel de réparation et de renouvellement, contribuant à l’homéostasie des tissus. Augmenter le nombre de cellules souches disponibles pour la réparation et le renouvellementtissulaire a démontré de nombreux bénéfices cliniques notamment pour les maladies cardiovasculaires, le diabète, les maladies hépatiques, intestinales et neuro-dégénératives. Bien que l’inflammation aiguë soit indispensable comme mécanisme de défense de l’organisme avec une mobilisation du système immunitaire pour protéger l’organisme d’infection, conduisant à la résolution de l’inflammation, la cicatrisation et la régénération des tissus, l’inflammation chronique qui s’installe sur le long temps est associée à des perturbations métaboliques importante. Certains mécanismes cellulaires discutés dans cette revue ont été clairement identifiés, illustrant le dysfonctionnement des cellules souches en cas d’inflammation chronique. Un défaut de réparation et de régénération cellulaire pourrait être ainsi présent en cas de pathologies chroniques inflammatoires, à travers un nombre insuffisant de cellules souches mobilisées ou étant en moindre capacité de migrer vers les tissus, pouvant aggraver ou entretenir la physiopathologie de la maladie. De nombreuses maladies chroniques inflammatoires sont notamment caractérisées par un nombre plus faible de cellules souches en circulation suggérant une capacité régénératrice et réparatrice réduite. Par conséquent, en associant des mobilisateurs naturels de cellules permettant d’augmenter le nombre de cellules souches en circulation disponibles pour la réparation, associés à des composés anti-inflammatoires issus d’extraits de plantes avec un profil de sécurité satisfaisant à long-terme permettrait de diminuer l’inflammation chronique et d’augmenter la capacité naturelle de l’organisme à se réparer et se régénérer, pouvant avoir des bénéfices cliniques sur la prise en charge des symptômes et sur la qualité de vie des patients de certaines pathologies chroniques inflammatoires.
Écritures de soi, Écritures des limites
Authors: Tellier Arnaud
Published: April 2021

Cette contribution a pour objet l’expérience du paysage et ses relations à l’écriture de soi. Qu’est-ce qui à l’intérieur de soi répond au paysage, à sa contemplation ? Qu’est-ce qui depuis le paysage, c’est-à-dire d’un certain point de vue , se trouve appelé de soi ? Comment s’opère cette correspondance ? Le propos se règle d’abord sur Jean-Jacques Rousseau et ses Rêveries d’un promeneur solitaire . Dans une seconde partie, les relations entre paysage et intériorité, leur superposition mémorielle, les mouvements psychiques causés par la flânerie dans le paysage et ses arrière-pays seront informés à partir de l’ouvrage de Georges-Arthur Goldschmidt, La forêt interrompue .
Écritures de soi, Écritures des limites
Authors: Waintrater Régine
Published: April 2021

Dans ce chapitre, on examinera le processus de mélancolisation tel qu’il se manifeste dans l’œuvre de l’écrivain-survivant de la Shoah, Jean Améry. La mélancolisation de la pensée provient de l’impossibilité de faire le deuil et de composer avec la perte. Chez Jean Améry, le refus de faire la paix avec les événements qui ont infléchi sa vie, se double d’un refus du temps qui passe. L’écriture, au lieu de lui fournir un étayage, devient l’instrument même de sa destruction, car toute entière dominée par la pulsion de mort, qu’aucun lien ne parvient à tempérer, jusqu’à son suicide.
Les élèves à besoins éducatifs particuliers à l’épreuve de l’égalité des chances au sein des EPLE
Authors: Jellab Aziz
Published: April 2021

Le propos de cet article vise à apporter une nouvelle contribution sociologique à l’appréhension de l’inclusion sous l’angle de l’autonomie des établissements scolaires, appelés à devenir davantage « autonomes » en renforçant le rôle pédagogique du chef d’établissement et des collectifs professionnels. Prenant acte du fait que l’égalité des chances procède partiellement des choix organisationnels et pédagogiques engagés par les établissements scolaires, nous postulons que l’inclusion des élèves en situation de handicap agit comme une injonction institutionnelle venant déstabiliser la norme scolaire. Parce que les vulnérabilités interrogent les pratiques pédagogiques ordinaires, elles sont de nature à opérer comme une variable, elles apparaissent comme une « marge » interpellant la norme. C’est à une « inclusion réciproque » qu’invite in fine l’analyse sociologique
La proximité du dirigeant et des administrateurs renforce-t-elle la position concurrentielle de la firme ?
Authors: Van Appelghem Cédric , Nguyen Pascal , Ben Zaied Younes
Published: April 2021

La France se distingue par un petit nombre d’écoles prestigieuses dont sont issues la plupart des élites économiques. Il en résulte une forte proximité entre dirigeants et administrateurs du point de vue de leur parcours éducatif. Cette proximité empêche le conseil d’administration d’exercer pleinement sa fonction disciplinaire, ce qui n’encourage pas le dirigeant à développer les actifs spécifiques nécessaires au renforcement de la position concurrentielle de la firme. Il en découle un risque systématique plus important, surtout lorsque la firme dispose de peu d’opportunités de croissance et qu’elle est de surcroit peu endettée. Toutefois, la présence d’un actionnaire de contrôle ou un suivi plus étroit par les analystes financiers contribue efficacement à atténuer l’effet de la proximité. Dans l’ensemble, nos résultats soulignent les problèmes liés à l’existence de relations sociales entre le dirigeant et les administrateurs et impliquent que les codes de gouvernance devraient en tenir compte. Classification JEL : G31, G34, D21
Manipulabilité coalitionnelle du vote par note à trois niveaux : quantification et comparaison à trois autres règles de vote
Authors: El Ouafdi Abdelhalim , Lepelley Dominique , Serais Jérôme , Smaoui Hatem
Published: April 2021

Toutes les règles de vote non dictatoriales sont manipulables par une coalition d’agents ; cependant, toutes ne présentent pas le même degré de manipulabilité. La vulnérabilité à la manipulation peut être évaluée par la fréquence des situations de vote – dites instables – où la manipulation est possible sous la règle considérée. Nous nous proposons dans cet article de mesurer la vulnérabilité de la règle de vote par note à trois niveaux (EV) à la manipulation stratégique par une coalition de votants lorsque les préférences sont trichotomiques et le nombre de candidats limité à trois. Pour pouvoir comparer les performances de EV à celles des règles de la pluralité, de l’antipluralité et de Borda, nous calculons aussi les fréquences théoriques des situations de vote instables sous chacune des extensions de ces trois règles au cadre des préférences trichotomiques. Classification JEL : D71, D72
Un modèle de comportement rationnel vis-à-vis de la pollution intérieure
Authors: Blanc Aurélien
Published: April 2021

La problématique de la pollution de l’air intérieur gagne en intérêt puisque les individus passent la majeure partie de leur temps à l’intérieur (90 % de leur temps aux États-Unis (Wei, Ramalho et Mandin [2015])), ce qui génère de nombreux troubles sanitaires (des cancers, des allergies par exemple (OMS [2010])). Nous modélisons la manière dont un individu optimise ses choix au cours de sa vie pour maximiser son utilité à travers un modèle de contrôle optimal. Nous montrons ainsi l’importance de la perception de la santé sur les actions de mitigation de la pollution. En se servant de simulations numériques, nous soulignons l’importance du revenu et de l’information sur la pollution de l’air intérieur pour la combattre.