bluuebunny/crossref_metadata_2025 huggingface dataset:
Disaster Preparedness: Hospital Pharmacy Strategy for Prioritized Inventory Management and Drug Procurement on Vancouver Island
Authors: Chen Denise , Wanbon Richard
Published: September 2022

Disaster events can increase demand for medication supplies and interfere with supply chains, leading to compromised care in hospitals. Providing an organized response to an additional surge of disaster-related patients requires pre-planned emergency management procedures. Hospital pharmacists can address this with prioritized drug procurement and inventory management strategies which may improve the availability of key medications for a disaster response. Previous disaster events have provided insight on medications used to treat disaster-related injuries and exacerbations of medical conditions in emergency departments. This article provides a detailed description of Vancouver Island’s hospital pharmacy strategy for the procurement and minimum stock levels of high priority medications in preparation for a disaster.
Susceptibility of native and invasive submersed plants in New Zealand to florpyrauxifen-benzyl in growth chamber exposure studies
Authors: Howell Andrew W. , Hofstra Deborah E. , Heilman Mark A. , Richardson Robert J.
Published: September 2022

Invasive aquatic plants constantly threaten freshwaters and associated environs globally. Water resource managers frequently seek new control tactics to combat invasive macrophytes, especially when the availability of herbicides registered for submersed plant control is limited. The synthetic auxin herbicide, florpyrauxifen-benzyl, recently registered (2018) for aquatic site applications in the United States, has shown success in controlling several invasive aquatic weeds. Studies were conducted to evaluate responses of native and invasive submersed plants to florpyrauxifen-benzyl under growth chamber conditions to provide insight on the selectivity of varying herbicide concentrations in New Zealand. Florpyrauxifen-benzyl concentrations evaluated ranged from 0.01 to 107.86 µg ai L−1, encompassing the maximum use concentration (48 µg L−1) for submersed plant applications. Dose–response metrics indicated the New Zealand native species watermilfoil [Myriophyllum triphyllum Orchard] was highly sensitive to florpyrauxifen-benzyl following a 21-d static exposure, having a dry weight 50% effective concentration (EC50) value of 1.2 µg L−1. The invasive species oxygen-weed [Lagarosiphon major (Ridley) Moss] and Canadian waterweed (Elodea canadensis Michx.) were less sensitive, with dry weight EC50 values of 35.4 and >107.86 µg L−1, respectively. Brazilian waterweed (Egeria densa Planch.) was most tolerant to the tested concentrations, as EC50 values were not achieved. Overall, results indicate florpyrauxifen-benzyl demonstrates potential for controlling L. major, with further large-scale screening required to confirm control among field site applications. As the native species (M. triphyllum) was most sensitive to florpyrauxifen-benzyl compared with the invasive plant evaluated (I/N ratio indicated >31.3 times more sensitive), any targeted concentration used for invasive plant control for field applications would likely injure the native M. triphyllum plants. Future studies should investigate additional native and invasive species for management guidance and consider how exposure times influence plant response using similar florpyrauxifen-benzyl concentrations tested in the present study.
Furlough and its effects on employees after returning to work: the roles of psychological contract breach and violation, and perceived organizational support
Authors: Delegach Marianna , Klein Galit , Katz-Navon Tal
Published: September 2022

The COVID-19 pandemic brought about changes in the working world. One of the main strategies to cope with the economic situation during lockdowns was to furlough employees. In the current study, we propose that psychological contract breach and violation between the organization and the furloughed employee act as underlying mechanisms that explain the relationship between the employees' furlough status and the increase in their emotional exhaustion and decrease in affective commitment. Furthermore, we suggest that perceived organizational support can act as a buffer that attenuates the association between furloughed employment status and perceived contract breach. The study was conducted at two points in time: during the first lockdown and 4 months afterward (N = 336). Results supported the predicted indirect sequential associations. However, perceived organizational support served to buffer the relationship between furloughed employment status and perceived psychological contract breach only in the case of employees who continued to work.
Applications of machine learning in computer-aided drug discovery
Authors: Turzo SM Bargeen Alam , Hantz Eric R. , Lindert Steffen
Published: September 2022

Machine learning (ML) has revolutionised the field of structure-based drug design (SBDD) in recent years. During the training stage, ML techniques typically analyse large amounts of experimentally determined data to create predictive models in order to inform the drug discovery process. Deep learning (DL) is a subfield of ML, that relies on multiple layers of a neural network to extract significantly more complex patterns from experimental data, and has recently become a popular choice in SBDD. This review provides a thorough summary of the recent DL trends in SBDD with a particular focus on de novo drug design, binding site prediction, and binding affinity prediction of small molecules.
Relative to processed red meat, alternative protein sources are associated with a lower risk of hypertension and diabetes in a prospective cohort of French women
Authors: Thao Uyen , Lajous Martin , Laouali Nasser , Severi Gianluca , Boutron-Ruault Marie-Christine , MacDonald Conor James
Published: September 2022

Many dietary guidelines recommend restricting the consumption of processed red meat (PRM) in favour of healthier foods such as fish, to reduce the risk of chronic conditions such as hypertension and diabetes. The objective of this study was to estimate the potential effect of replacing PRM for fatty fish, lean fish, red meat, eggs, pulses, or vegetables, on the risk of incident hypertension and diabetes. This was a prospective study of women in the E3N cohort study. Cases of diabetes and hypertension were based on self-report, specific questionnaires, and drug reimbursements. In the main analysis, information on regular dietary intake was assessed with a single food history questionaire, and food substitutions were modelled using cox proportional hazard models. 95 % confidence intervals were generated via bootstrapping. 71 081 women free of diabetes and 45 771 women free of hypertension were followed for an average of 18·7 and 18·3 years, respectively. 2681 incident cases of diabetes and 12 327 incident cases of hypertension were identified. Relative to PRM, fatty fish was associated with a 15 % lower risk of diabetes (HR = 0·85, 95 CI (0·73, 0·97)) and hypertension (HR = 0 85 (0·79, 0·91)). Between 3 and 10 % lower risk of hypertension or diabetes was also observed when comparing PRM with vegetables, unprocessed red meat or pulses. Relative to PRM, alternative protein sources such as fatty fish, unprocessed red meat, vegetables or pulses was associated with a lower risk of hypertension and diabetes.
J-shaped association between dietary copper intake and all-cause mortality: a prospective cohort study in Chinese adults
Authors: Gan Xiaoqin , He Panpan , Zhou Chun , Zu Cheng , Meng Qiguo , Liu Mengyi , Zhang Yuanyuan , Yang Sisi , Zhang Yanjun , Ye Ziliang , Wu Qimeng , Li Rui , Liu Chengzhang , Qin Xianhui
Published: September 2022

The association between dietary Cu intake and mortality risk remains uncertain. We aimed to investigate the relationship of dietary Cu intake with all-cause mortality among Chinese adults. A total of 17 310 participants from the China Health and Nutrition Survey, a national ongoing open cohort of Chinese participants, were included in the analysis. Dietary intake was measured by three consecutive 24-h dietary recalls in combination with a weighing inventory over the same 3 d. The average intakes of the 3-d dietary macronutrients and micronutrients were calculated. The study outcome was all-cause mortality. During a median follow-up of 9·0 years, 1324 (7·6 %) participants died. After adjusting for sex, age, BMI, ever alcohol drinking, ever smoking, education levels, occupations, urban or rural residents, systolic blood pressure, diastolic blood pressure and the intakes of fat, protein and carbohydrate, the association between dietary Cu intake and all-cause mortality followed a J-shape (Pfor nonlinearity = 0·047). When dietary Cu intake was assessed as quartiles, compared with those in the first quartile (<1·60 mg/d), the adjusted hazard ratios for all-cause mortality were 0·87 (95 % CI (0·71, 1·07)), 0·98 (95 % CI (0·79, 1·21)) and 1·49 (95 % CI (1·19, 1·86)), respectively, in participants in the second (1·60–<1·83 mg/d), third (1·83–<2·09 mg/d) and fourth (≥2·09 mg/d) quartiles. A series of subgroup analyses and sensitivity analyses showed similar results. Overall, our findings emphasised the importance of maintaining optimal dietary Cu intake levels for prevention of premature death.
Effect of taurine on glycaemic, lipid and inflammatory profile in individuals with type 2 diabetes: study protocol of a randomised trial
Authors: Caletti Greice , Cardoso Monique Vargas , Scheffel Rafael Selbach , Schaan Beatriz D. , Gomez Rosane , Bock Patrícia Martins
Published: September 2022

Type 2 diabetes mellitus (T2DM) is characterised by chronic hyperglycaemia. Despite the efficacy of conventional pharmacotherapy, some individuals do not reach glycaemic goals and require adjuvant therapies. Taurine, a semi-essential amino acid, decreases blood glucose and cholesterol levels in rodents and humans. However, glycated hemoglobin (HbA1c) has not been evaluated in randomised controlled trials after taurine treatment for more than 12 weeks. This study aims to evaluate the effect of taurine administration on glycaemic, lipid, inflammatory, anthropometric and dietary parameters in individuals with T2DM. A randomised, double-blind, placebo-controlled clinical trial will be conducted at the Clinical Research Center of a tertiary public hospital. Participants with T2DM (n 94) will be recruited and randomised to receive 3 g of taurine or placebo, twice/day, orally, for 12 weeks. Blood samples will be collected before and after 12 weeks of treatment, when HbA1c, fasting glucose, insulin, albuminuria, creatinine, total cholesterol and fractions, triglycerides, C-reactive protein, TNF-α, IL 1, 4, 5, 6, 10 and 13 will be evaluated. Anthropometric parameters and 24-hour food recall will also be evaluated. The study will evaluate the effect of taurine treatment on biochemical and anthropometric parameters in individuals with T2DM. These results will guide the decision-making to indicate taurine treatment as an adjunct in individuals with T2DM who have not reached their glycaemic goal.
l-Leucine supplementation reduces growth performance accompanied by changed profiles of plasma amino acids and expression of jejunal amino acid transporters in breast-fed intra-uterine growth-retarded piglets
Authors: Ji Yun , Sun Yuli , Liu Ning , Jia Hai , Dai Zhaolai , Yang Ying , Wu Zhenlong
Published: September 2022

Previously, we provided an evidence that l-Leucine supplementation facilitates growth performance in suckling piglets with normal birth weight. However, it remains hitherto obscure weather breast-fed piglets displaying intra-uterine growth restriction (IUGR) show a similar effect in response to l-Leucine provision. In this study, 7-d-old sow-reared IUGR piglets were orally administrated with l-Leucine (0, 0·7, 1·4 or 2·1 g/kg BW) twice daily for 2 weeks. Increasing leucine levels hampered the growth performance of suckling IUGR piglets. The average daily gain of IUGR piglets was significantly reduced in 1·4 g/kg BW and 2·1 g/kg BW l-Leucine supplementation groups (P < 0·05). Except for ornithine and glutamine, the plasma concentrations of other amino acids were abated as l-Leucine levels increased (P < 0·05). Leucine supplementation led to reduction in the levels of urea, blood ammonia, blood glucose, TAG and total cholesterol, as well as an elevation in the level of LDL-cholesterol in suckling IUGR piglets (P < 0·05). In addition, 1·4 g/kg BW of l-Leucine enhanced the mRNA expression of ATB0,+, whereas decreased the mRNA abundances of CAT1, y + LAT1, ASCT2 and b0,+AT in the jejunum (P < 0·05). Concomitantly, the jejunum of IUGR piglets in l-Leucine group contains more ATB0,+ and less SNAT2 protein than in the control (P < 0·05). Collectively, l-Leucine supplementation impairs growth performance in breast-fed IUGR piglets, which may be associated with depressed nutritional conditions and alterations in the uptake of amino acids and the expression of amino acid transporters in the small intestine.
A Climate of Confessionalization: Famine and Difference in the Late Ottoman Empire
Authors: Ghazarian Matthew
Published: September 2022

After the 1877–78 Russo-Ottoman War, the Ottoman Empire saw the rise of ethnic and sectarian clashes in Anatolia, the Balkans, and elsewhere, and the task of explaining that rise remains unfinished. Many have examined the intellectual formations of ethnic and sectarian solidarities after 1878, but the availability of new ideas cannot alone account for their widespread uptake. Why after 1878 did ordinary people respond more to calls upon ethnic and sectarian solidarity? Drawing on sources surrounding the 1879 famine in the Ottoman East, this article steps away from imperial metropoles to examine overlapping environmental, financial, and technological disjunctures. Adopting the methods of political ecology, the article underscores the simultaneous effects of drought, sovereign default, and an influx of modern weapons, each of which imposed uneven hardships along ethno-religious lines. Together, they created a climate of lived confessionalization that highlighted the communal categories upon which emergent movements called.
The Digital Credit Divide: Marketplace Lending and Entrepreneurship
Authors: Cumming Douglas , Farag Hisham , Johan Sofia , McGowan Danny
Published: September 2022

We conjecture that marketplace lending provokes an increase in the quantity of entrepreneurship, particularly in more regionally disadvantaged areas, albeit at lower average quality. Using a fuzzy regression discontinuity design that exploits exogenous variation in borrowers’ access to marketplace loans along U.S. state borders, we estimate a 10% increase in marketplace lending causes a 0.44% increase in business establishments per capita. The effects are more pronounced for less experienced entrepreneurs, for small and less profitable firms, firms more dependent upon external finance, in industries with lower sunk costs of entry, and for low-income regions with inferior access to financial institutions.
A first look at the genetic diversity of Enteroctopus megalocyathus (Cephalopoda: Enteroctopodidae) captured by the king crab fishery in the south of Chile
Authors: Pliego-Cárdenas Ricardo , Schofield-Astorga Diana C. , Acuña-Gómez Eliana Paola , Barriga-Sosa Irene de los Angeles
Published: September 2022

The octopus fishery in the southern tip of South America is based on Enteroctopus megalocyathus. It is fished on both the Atlantic and Pacific coasts, but no study has yet investigated the genetic variability of this octopus, which is frequently collected as bycatch. The genetic identity and diversity of E. megalocyathus from specimens caught by the king crab fishery along the Beagle Channel in southern Chile was investigated using sequences of three mitochondrial (16S rRNA, COI and COIII) and one nuclear (rhodopsin) markers. Homologous sequences from other Enteroctopodidae were included to determine the genetic variability of E. megalocyathus. In addition to E. megalocyathus, genetic data allowed us to identify Muusoctopus eureka, a species also collected by the king crab fishery. Enteroctopus megalocyathus was found to be genetically similar to E. zealandicus; the genetic distances between these two species were low, 0% (16S rRNA), 0.2% (COI) and 0.6% (COIII), which was also confirmed by the phylogenetic topologies, as both species are in the same clade. Enteroctopus megalocyathus has low levels of genetic diversity, as shown by haplotype and nucleotide diversity values for the mitochondrial markers (Hd = 0.06–0.32; π = 0.0001–0.003), and null diversity for the nuclear marker. All the haplotypic networks resolved with the mtDNA markers showed shared haplotypes among E. megalocyathus, E. magnificus and E. zealandicus. The low genetic diversity of E. megalocyathus can be attributed to both the geological history of South America and the life history of the species, rather than to the king crab fishery.
Physical and feasible: Climate change adaptation in Longyearbyen, Svalbard
Authors: Meyer Alexandra
Published: September 2022

Longyearbyen, Svalbard, has become showcase of Arctic climate change. However, we know little about how these changes are dealt with locally. This article aims to fill this gap by examining climate change impacts and adaptation in a non-Indigenous “community of experts” and sets out to 1) describe observed changes and perceived societal impacts of climate change and 2) discuss adaptation measures and related understandings of adaptation. The research consists of ethnographic fieldwork and interviews with planners, engineers, architects, scientists, construction workers and local politicians. The research finds that climate change impacts the built environment in Longyearbyen, and that there is vast awareness of and concern related to these impacts. There is a substantial knowledge base for adaptation, and a special trust in scientific knowledge, skills and experts. The interview partners consider adaptation as necessary and feasible. Adaptation is understood and implemented as technical responses to physical problems, rooted in a modernist understanding of the environment as separated from humans, who can control it through technical means. This suggests a narrow understanding of adaptation that might fail to address more socially transformative processes.
Can speakers of different languages be saying the same thing? Influences of non-native language exposure and explicit comparison on children’s language awareness
Authors: Rojo Dolly P. , Echols Catharine H. , Griffin Zenzi M.
Published: September 2022

Language awareness (LA)—an understanding of the communicative functions and conventions of language—could benefit monolingual children as they navigate their increasingly multilingual world. To evaluate how non-native language exposure influences English-speaking children’s understanding that different languages can convey equivalent information, 63 5–7-year-olds compared utterances in English and Lithuanian (unfamiliar to all participants). Half of the children also compared English utterances to Spanish (a widely spoken language in their community—94% of children had some past exposure), whereas the other half compared English utterances to Tagalog (unfamiliar to all participants). Children in the Spanish condition were significantly more likely than those in the Tagalog condition to agree that a Lithuanian and an English speaker could be saying the same thing. We argue that children’s experience with Spanish as a community language, coupled with explicit questioning about commonalities between languages, served to scaffold an understanding of LA.
The home environment: influences on the health of young-old and old-old adults in Australia
Authors: Aplin Tammy , Lowies Braam , McGreal Stanley
Published: September 2022

The physical and societal characteristics of home have been established as important in influencing the health and wellbeing of older adults, yet these have rarely been explored together. There is also limited research into variation across age groups, with older adults often examined as a homogenous group of those 65 years and over. This study advances the knowledge base by using the concept of person–environment (P-E) fit to analyse differences in personal and home environment (physical and societal) characteristics between young-old (65–74 years) and old-old (75 and above) age groups, and to assess how these characteristics influence their self-perceived health. This cross-sectional study draws upon survey data from 1,999 older adult participants from the Australian Housing Conditions Dataset. Descriptive statistics and inferential analysis were used to assess for significant differences between age groups and a binomial logistic regression was utilised to examine influences on health. The analysis found that the factors which influence health varies appreciably between age groups. For the young-old financial strain, being on the fixed-income pension and hypertension were important contributing factors, in contrast for the old-old gender (being male), having depression and the home being modified for disability were key influences. For both age groups heart disease was a contributing factor to perceived health. The results indicate the important contribution to knowledge of incorporating a wide range of person and environment characteristics when exploring P-E fit for older adults. The inclusion of societal aspects, such as financial strain, fixed-income pension, tenure and access to community aged care services when exploring influences on health, arises as a key conclusion of the study. In terms of impact, this research is significant given rising inequalities globally and specifically in the Australian context, the need for policy measures to address income inequality, and its health and social implications for older households.
Reconfigurable fully constrained cable-driven parallel mechanism for avoiding collision between cables with human
Authors: Khoshbin Elham , Youssef Khaled , Meziane Ramy , Otis Martin J.-D.
Published: September 2022

Productivity can be increased by manipulators tracking the desired trajectory with some constraints. Humans as moving obstacles in a shared workspace are one of the most challenging problems for cable-driven parallel mechanisms (CDPMs) that are considered in this research. One of the essential primary issues in CDPM is collision avoidance among cables and humans in the shared workspace. This paper presents a model and simulation of a reconfigurable, fully constrained CDPM enabling detection and avoidance of cable–human collision. In this method, unlike conventional CDPMs where the attachment points are fixed, the attachment points on the rails can be moved (up and down on their rails), and then the geometric configuration is adapted. Karush–Kuhn–Tucker method is proposed, which focuses on estimating the shortest distance among moving obstacles (human limbs) and all cables. When cable and limbs are close to colliding, the new idea of reconfiguration is presented by moving the cable’s attachment point on the rail to increase the distance between the cables and human limbs while they are both moving. Also, the trajectory of the end effector remains unchanged. Some simulation results of reconfiguration theory as a new approach are shown for the eight-cable-driven parallel manipulator, including the workspace boundary variation. The proposed method could find a collision-free predefined path, according to the simulation results.
Making Policies: The History of the Danish Child Welfare System at the Local Level
Authors: BJERRE CECILIE
Published: September 2022

This article examines out-of-home placements in Denmark over a seven-decade period from 1905 to 1975. The Danish state delegated this responsibility to a, using the words of Kimberly J. Morgan and Ann Shola Orloff, “difficult-to-classify public-private hybrid,” the Children’s Welfare Boards (CWBs). These CWBs comprised private citizens selected by the municipality. The article shows how the CWBs acted as interpreters, mediators, and implementers of state policy at the street level while also functioning as the direct link between government and citizens. The findings reveal an inherent conflict between center and periphery in that the state’s nationwide regulations and bureaucratic practices, intended to apply to all citizens uniformly, were to be implemented by local units within municipalities that operated according to logics other than those of the state. The vase of variations in child out-placement practices shows the importance of examining local variations in studying the history of policy implementation.
The persistent workforce: female day labour on capitalist farms in eighteenth-century Flanders
Authors: Helsen Lore
Published: September 2022

Female day labourers regularly appear in the accounts of capitalist Flemish farmers throughout the eighteenth century. Their persistent employment challenges the dominant view that female day labour was marginalised in areas of agrarian capitalism across the eighteenth and nineteenth centuries. The hitherto unexplored accounts of nine capitalist farms reveal the seasonal employment patterns, sexual division of labour and wages of those female day labourers in Flanders. While spring weeding was an important source of employment, women also continued to be hired during the harvest and for the cultivation of labour-intensive crops. Throughout the century, female day wages amounted to 0.4–0.73 of male wages. Women were excluded from well-paid tasks, but equal rates for equal work do not suggest wage discrimination in the strictest sense. The Flemish accounts thus reinforce the idea that female day labour persisted in areas with labour-intensive agriculture and alternative employment opportunities.
Transcatheter retrieval of embolised fractured peripherally inserted central catheter: a nightmare in very low birth weight preterm neonate
Authors: Bishnoi Suresh , Banerji Nayan , Champaneri Bhavik , Deodhar Shilpa
Published: September 2022

Peripherally inserted central catheters are commonly used for intravascular access in low birth weight neonates. Here, we describe a case of transcatheter retrieval of an embolised peripherally inserted central catheter line in the right ventricle extending to the left pulmonary artery in a preterm very low birth weight baby. To the best of our knowledge, this is the first case where transcatheter retrieval of embolised peripherally inserted central catheter line has been done from the left pulmonary artery in such a very low birth weight preterm neonate. Although retrieval of foreign body is common in adults and older children, very few case reports have documented successful retrieval of embolised peripherally inserted central catheter line in very low birth weight neonates using interventional techniques. Most of the cases in literature reported retrieval of an indwelling umbilical venous catheter rather than a peripherally inserted central catheter line as in our case. Also, none of these cases had the embolised fragment retrieved from the left pulmonary artery. This approach was technically very challenging as we were taking care of a 5-day old preterm neonate born at 32 weeks of gestation having very low birth weight (1100 g) with features of clinical sepsis, coagulopathy, and embolised catheter fragment extending from right ventricle to left pulmonary artery. The procedure was uneventful without any complication and the catheter was retrieved successfully.
Dietary intake and educational outcomes among Australian university students: cross-sectional and longitudinal associations
Authors: Babaeer Lena , Stylianou Michalis , Walker Jacqueline L , Gomersall Sjaan R
Published: September 2022

Objective:

This study aimed to examine cross-sectional and longitudinal associations between dietary intake and educational outcomes (EO) in Australian first-year university students.

Design:

This cross-sectional and longitudinal study measured outcomes of interest at three points over 1 year. Measures included self-reported dietary patterns and dietary intake via a three-day estimated food record. Objective EO (corresponding semester grade point average (GPA), overall GPA and graduation status) variables were extracted from academic records. Cross-sectional and longitudinal associations were examined using regression models and generalised estimating equations, respectively.

Setting:

A large university in Queensland, Australia.

Participants:

Participants (n 80) were first-year students who had completed high school in the previous year.

Results:

Some significant associations were found with semester GPA, including: (a) moderate positive associations between serves of vegetables and semester GPA at time point 2 and over time; and (b) a weak negative association between Na intake and semester GPA at time point 2. Although insignificant, meaningful negative associations were found between alcohol consumption and semester GPA at time point 1 and over time. Some significant associations were also found with graduation status, including: (a) a positive association between meeting Australian carbohydrate recommendations and graduation status; and (b) a negative association between Fe intake and graduation status, both at time point 1.

Conclusions:

Both cross-sectional and longitudinal findings highlight positive associations between vegetable intake and EO and negative associations between alcohol consumption and EO. Further relevant work is needed with larger, more variable samples in demographic, dietary and EO characteristics.
VARIANTS OF A MULTIPLIER THEOREM OF KISLYAKOV
Authors: Defant Andreas , Mastyło Mieczysław , Pérez-Hernández Antonio
Published: September 2022

We prove stronger variants of a multiplier theorem of Kislyakov. The key ingredients are based on ideas of Kislyakov and the Kahane–Salem–Zygmund inequality. As a by-product, we show various multiplier theorems for spaces of trigonometric polynomials on the n-dimensional torus
$\mathbb {T}^n$
or Boolean cubes
$\{-1,1\}^N$
. Our more abstract approach based on local Banach space theory has the advantage that it allows to consider more general compact abelian groups instead of only the multidimensional torus. As an application, we show that various recent
$\ell _1$
-multiplier theorems for trigonometric polynomials in several variables or ordinary Dirichlet series may be proved without the Kahane–Salem–Zygmund inequality.
Thinking EU Militant Democracy beyond the Challenge of Backsliding Member States
Authors: Feisel Franca Maria
Published: September 2022

EU militant democracy – an approach beyond member states’ democratic backsliding – the EU as a first case of transnational democratic self-defence – the EU’s democratic legitimacy – national and supranational threats to EU democracy – instruments and enforcement of EU militant democracy – comparison to national militant democracy – problems of effectiveness
Trade‐Offs for Climate‐Smart Forestry in Europe Under Uncertain Future Climate
Authors: Gregor Konstantin , Knoke Thomas , Krause Andreas , Reyer Christopher P. O. , Lindeskog Mats , Papastefanou Phillip , Smith Benjamin , Lansø Anne‐Sofie , Rammig Anja
Published: September 2022

Forests mitigate climate change by storing carbon and reducing emissions via substitution effects of wood products. Additionally, they provide many other important ecosystem services (ESs), but are vulnerable to climate change; therefore, adaptation is necessary. Climate‐smart forestry combines mitigation with adaptation, whilst facilitating the provision of many ESs. This is particularly challenging due to large uncertainties about future climate. Here, we combined ecosystem modeling with robust multi‐criteria optimization to assess how the provision of various ESs (climate change mitigation, timber provision, local cooling, water availability, and biodiversity habitat) can be guaranteed under a broad range of climate futures across Europe. Our optimized portfolios contain 29% unmanaged forests, and implicate a successive conversion of 34% of coniferous to broad‐leaved forests (11% vice versa). Coppices practically vanish from Southern Europe, mainly due to their high water requirement. We find the high shares of unmanaged forests necessary to keep European forests a carbon sink while broad‐leaved and unmanaged forests contribute to local cooling through biogeophysical effects. Unmanaged forests also pose the largest benefit for biodiversity habitat. However, the increased shares of unmanaged and broad‐leaved forests lead to reductions in harvests. This raises the question of how to meet increasing wood demands without transferring ecological impacts elsewhere or enhancing the dependence on more carbon‐intensive industries. Furthermore, the mitigation potential of forests depends on assumptions about the decarbonization of other industries and is consequently crucially dependent on the emission scenario. Our findings highlight that trade‐offs must be assessed when developing concrete strategies for climate‐smart forestry.
Systematic Climate Model Biases in the Large‐Scale Patterns of Recent Sea‐Surface Temperature and Sea‐Level Pressure Change
Authors: Wills Robert C. J. , Dong Yue , Proistosecu Cristian , Armour Kyle C. , Battisti David S.
Published: September 2022

Observed surface temperature trends over recent decades are characterized by (a) intensified warming in the Indo‐Pacific Warm Pool and slight cooling in the eastern equatorial Pacific, consistent with Walker circulation strengthening, and (b) Southern Ocean cooling. In contrast, state‐of‐the‐art coupled climate models generally project enhanced warming in the eastern equatorial Pacific, Walker circulation weakening, and Southern Ocean warming. Here we investigate the ability of 16 climate model large ensembles to reproduce observed sea‐surface temperature and sea‐level pressure trends over 1979–2020 through a combination of externally forced climate change and internal variability. We find large‐scale differences between observed and modeled trends that are very unlikely (<5% probability) to occur due to internal variability as represented in models. Disparate trends in the ratio of Indo‐Pacific Warm Pool to tropical‐mean warming, which shows little multi‐decadal variability in models, hint that model biases in the response to historical forcing constitute part of the discrepancy.
Simultaneous Inversion for Surface Wave Phase Velocity and Earthquake Centroid Parameters: Methodology and Application
Authors: Xiao Xiao , Sun Li , Wang Xiaoxin , Wen Lianxing
Published: September 2022

Both the regional earthquake surface wave and seismic ambient noise provide important constraints on the Earth's structure, and yet no study satisfactorily combined them for the best imaging of subsurface seismic structure. In this study, we address this issue by developing a new method to simultaneously determine surface wave phase velocity and earthquake centroid parameters in three steps: (a) preliminary phase velocity inversion based on seismic ambient noise, (b) preliminary earthquake relocation based on earthquake surface wave data, and (c) simultaneous inversion for phase velocity and earthquake centroid parameters with constraints of interstation phase velocity measurements based on seismic ambient noise and event‐station phase velocity measurements based on earthquake surface wave data. Application of the method in the North South Seismic Belt region in China results in high‐resolution Rayleigh wave phase velocity maps and accurate earthquake centroid parameters. The additional earthquake data notably improve resolution of the inverted phase velocity model in west Yunnan and central Tibetan blocks, the regions with sparse seismic station coverage. The inverted phase velocity model exhibits high‐velocity anomalies in cratonic regions and the Emeishan Large Igneous Province, and low‐velocity anomalies in the interior and surrounding regions of the Tibetan Plateau. Relocation places earthquakes in shallow depths with geotherm above the crustal rock's brittle‐ductile transition temperature of , revealing thermal control on thickness of the seismogenic zone. With earthquake centroid parameters constrained, earthquake data are expected to provide further constraints on the deep seismic structure that is beyond the sampling limit of seismic ambient noise.
Tracing the Formation of Secondary Aerosols Influenced by Solar Radiation and Relative Humidity in Suburban Environment
Authors: Wu Yangzhou , Liu Dantong , Tian Ping , Sheng Jiujiang , Liu Quan , Li Ruijie , Hu Kang , Jiang Xiaotong , Li Siyuan , Bi Kai , Zhao Delong , Huang Mengyu , Ding Deping , Wang Junfeng
Published: September 2022

Secondary particulate matter exerts adverse effects on air quality and human health. The production or reaction rate of secondary aerosols in polluted environments remains uncertain and is complicated by diverse emissions and meteorological conditions. By concurrently measuring the mass spectra of compounds in both particulate (using an aerosol mass spectrometer) and gas phases (using proton‐transfer‐reaction mass spectrometry) in suburban Beijing, we linked the secondary organic aerosol (OA) and volatile organic compounds (VOCs) to photochemical age (tage) and obtained their reaction or production rates. Factorization analysis of the mass spectra of OA and the 108 VOC species resolved three oxygenated OAs (OOA) and three secondary VOC factors at different oxidation levels. Primary organic aerosols and VOCs from traffic sources were determined to be important sources for secondary aerosol formation. At high pollution levels under the conditions of weaker solar radiation and higher relative humidity, moderately oxygenated OA (O/C = 0.61) and secondary inorganics were coproduced in combination with rapid consumption of all VOCs. At lower pollution levels, the intense solar radiation caused substantial and rapid production of OOA (O/C = 0.81) and intermediate VOCs (both in a high oxidation state) at a rate of 15.0% h−1 and 14.0% h−1, respectively. These results highlight the feedback effects between radiation and moisture in terms of altering the formation mechanism of secondary aerosols. In particular, highly oxygenated secondary airborne products under strong radiation should be considered in regard to their environmental impact.
Water‐Soluble Organic Matter From Soils at the Terrestrial‐Aquatic Interface in Wetland‐Dominated Landscapes
Authors: Wardinski Katherine M. , Hotchkiss Erin R. , Jones C. Nathan , McLaughlin Daniel L. , Strahm Brian D. , Scott Durelle T.
Published: September 2022

Hydrologic controls on carbon processing and export are a critical feature of wetland ecosystems. Hydrologic response to climate variability has important implications for carbon‐climate feedbacks, aquatic metabolism, and water quality. Little is known about how hydrologic processes along the terrestrial‐aquatic interface in low‐relief, depressional wetland catchments influence carbon dynamics, particularly regarding soil‐derived dissolved organic matter (DOM) transport and transformation. To understand the role of different soil horizons as potential sources of DOM to wetland systems, we measured water‐soluble organic matter (WSOM) concentration and composition in soils collected from upland to wetland transects at four Delmarva Bay wetlands in the eastern United States. Spectral metrics indicated that WSOM in shallow organic horizons had increased aromaticity, higher molecular weight, and plant‐like signatures. In contrast, WSOM from deeper, mineral horizons had lower aromaticity, lower molecular weights, and microbial‐like signatures. Organic soil horizons had the highest concentrations of WSOM, and WSOM decreased with increasing soil depth. WSOM concentrations also decreased from the upland to the wetland, suggesting that continuous soil saturation reduces WSOM concentrations. Despite wetland soils having lower WSOM, these horizons are thicker and continuously hydrologically connected to wetland surface and groundwater, leading to wetland soils representing the largest potential source of soil‐derived DOM to the Delmarva Bay wetland system. Knowledge of which soil horizons are most biogeochemically significant for DOM transport in wetland ecosystems will become increasingly important as climate change is expected to alter hydrologic regimes of wetland soils and their resulting carbon contributions from the landscape.
Estimation Model of Global Ionospheric Irregularities: An Artificial Intelligence Approach
Authors: Tian Penghao , Yu Bingkun , Ye Hailun , Xue Xianghui , Wu Jianfei , Chen Tingdi
Published: September 2022

The ionospheric sporadic E layer, the ionospheric irregularities of enhanced electron density, appears in the Earth's ionosphere at altitudes between 90 and 120 km, which supports the real‐world radio communication needs of many sectors reliant on ionosphere‐dependent decision‐making. The prediction of the occurrence of sporadic E layers has been extremely difficult due to the highly complex behavior. Conventional numerical methods are limited because of the inability to extract high‐level information from data. Deep learning is a powerful tool for mining latent features from data, which can theoretically avoid assumptions constraining physical methods. Inspired by feature extraction, we applied deep learning to explore latent relationships between mapping observable lower atmospheric data and ionospheric data from limited observations. The proposed model was trained with high‐resolution ERA5 data during 1 January 2007–30 August 2018 as input and corresponding ionospheric sporadic E data collected from COSMIC RO measurements as output. The results show that the model can learn complex relevance as bridges connecting the input and the desired output and obtain excellent performance and generalization capability by applying multiple evaluation criteria. Additionally, we established several model architecture training methods to explore the performance of the model with different input data. The statistic results show that model inference performance is proportional to the abundance of input information and is impacted by intraseasonal variability. The inference capability of the model achieves the best performance in the June–August (JJA) and December–February (DJF) seasons, which is the exact period of sporadic E layer significant occurrence, although different models are evaluated.
Fast frequency relocking for synchronization enhanced resonant accelerometer
Authors: Xu Liu , Qi Yonghong , Jiang Zhuangde , Wei Xueyong
Published: September 2022

Synchronization, as a unique phenomenon, has been extensively studied in biology, chaotic systems, nonlinear dynamics, quantum information, and other fields. Benefiting from the characteristics of frequency amplification, noise suppression, and stability improvement, synchronization has been gradually applied in sensing, communication, time keeping, and other applications. In the sensing field, synchronization provides a new strategy to improve the performance of sensors. However, the performance improvement is only effective within the synchronization range, and the narrow synchronization range has become a great challenge for the wide application of synchronization-enhanced sensing mechanism. Here, we propose a frequency automatic tracking system (FATS) to widen the synchronization range and track the periodic acceleration signals by adjusting the frequency of the readout oscillator in real time. In addition, a high-precision frequency measurement system and fast response control system based on FPGA (Field Programmable Gate Array) are built, and the tracking performance of the FATS for static and dynamic external signals is analyzed to obtain the optimal control parameters. Experimental results show that the proposed automatic tracking system is capable of static acceleration measurement, the synchronization range can be expanded to 975 Hz, and the relocking time is shortened to 93.4 ms at best. By selecting the optimal PID parameters, we achieve a faster relocking time to meet the requirements of low-frequency vibration measurements, such as seismic detection and tidal monitoring.
Exercise training maintains cardiovascular health: signaling pathways involved and potential therapeutics
Authors: Chen Huihua , Chen Chen , Spanos Michail , Li Guoping , Lu Rong , Bei Yihua , Xiao Junjie
Published: September 2022

Exercise training has been widely recognized as a healthy lifestyle as well as an effective non-drug therapeutic strategy for cardiovascular diseases (CVD). Functional and mechanistic studies that employ animal exercise models as well as observational and interventional cohort studies with human participants, have contributed considerably in delineating the essential signaling pathways by which exercise promotes cardiovascular fitness and health. First, this review summarizes the beneficial impact of exercise on multiple aspects of cardiovascular health. We then discuss in detail the signaling pathways mediating exercise’s benefits for cardiovascular health. The exercise-regulated signaling cascades have been shown to confer myocardial protection and drive systemic adaptations. The signaling molecules that are necessary for exercise-induced physiological cardiac hypertrophy have the potential to attenuate myocardial injury and reverse cardiac remodeling. Exercise-regulated noncoding RNAs and their associated signaling pathways are also discussed in detail for their roles and mechanisms in exercise-induced cardioprotective effects. Moreover, we address the exercise-mediated signaling pathways and molecules that can serve as potential therapeutic targets ranging from pharmacological approaches to gene therapies in CVD. We also discuss multiple factors that influence exercise’s effect and highlight the importance and need for further investigations regarding the exercise-regulated molecules as therapeutic targets and biomarkers for CVD as well as the cross talk between the heart and other tissues or organs during exercise. We conclude that a deep understanding of the signaling pathways involved in exercise’s benefits for cardiovascular health will undoubtedly contribute to the identification and development of novel therapeutic targets and strategies for CVD.