bluuebunny/crossref_metadata_2025 huggingface dataset:
An optimized method for detection of MECP2 point mutations in Vietnamese children with rett syndrome
Authors:   Children’s Hospital II HCM, Vietnam, LÊ VÂN THỊ KHÁNH , LÊ DƯƠNG DUY THÁI ,   Ton Duc Thang University, Vietnam, ĐỖ HẰNG THỊ THU ,   School of Medicine-VNU HCM, Vietnam, HUỲNH KIỀU THỊ THÚY ,   Children’s Hospital II HCM, Vietnam, LÊ HIẾU TRUNG NGUYỄN ,   Children’s Hospital II HCM, Vietnam, BÙI DUNG THỊ THÙY ,   Nong Lam University HCM, Vietnam, NGUYỄN VŨ THANH ,   School of Medicine-VNU HCM, Vietnam, NGUYỄN DŨNG QUỐC ,   School of Medicine-VNU HCM, Vietnam, HUYNH HIEN THI DIEU ,   School of Medicine-VNU HCM, Vietnam
Published: September 2023

Background: Rett syndrome is a rare disease but affecting severe brain dysfunction. The rate of the syndrome is estimated to be 1/10,000–1/15,000 female births. This disorder is knowledge caused by de novo mutations in the MECP2 gene. More than 80% of patients with Rett syndrome have a point mutations in MECP2. The study correlation genotype-phenotype open to therapeutic opportunities for patients. In Vietnam, to validate the diagnosis, the doctors are mainly clinical diagnostic standards, not include genetics testing. Therefore, optimize the producer to determine MECP2 variations is necessary that provides evidence for clinical diagnosis, supporting the earlystage diagnosis of pediatric patients. Methods: Standardization of the MECP2 gene testing sequence used the healthy control blood samples includes PCR optimization and Sanger sequencing. Read raw sequence data by CLC workbench software. Analysis variations; evaluate the pathogenic of the variants with ACMG standard. After that, the process was applied to 4 pediatric patients with Rett syndrome treated at Children's Hospital II from 01/2019 to 12/2019. Result: We successfully optimized PCR-Sanger sequencing for the testing MECP2 variants gene, especially in exon 1 had high GC-percent (> 65%). The quality sequencing result was quite reliable. We found two pathogenic mutations (p.R294X, p.K29X); and a novel mutation (p.K29X). Conclusion: The process of the test gene MECP2 by PCR technique-Sanger sequencing was optimized completely, and add a novel mutation to the MECP2 variation database.
The total oxidant status and total antioxidant capacity of saliva in patients with chronic periodontitis before and after non – surgical periodontal treatment
Authors:   Faculty of Odonto-stomatology,University of Medicine and Pharmacy atHo Chi Minh City, Ho Chi Minh City,Vietnam, Nguyễn Linh Hà Khánh , Võ Thùy Lâm ,   University of Medicine and Pharmacy, Ho Chi Minh City, Nguyễn Thủy Thu ,   Department of Periodontology, Facultyof Odonto-stomatology, University ofMedicine and Pharmacy at Ho ChiMinh City, Ho Chi Minh City, Vietnam
Published: September 2023

Objective: The aim of this study was to measure the total oxidant status (TOS) and total antioxidant capacity (TAOC) levels in the saliva of patients with chronic periodontitis, before and after non – surgical periodontal treatment (NSPT). In addition, we aimed to investigate the correlation between salivary TOS, TAOC levels and periodontal parameters. Materials and Method: This longitudinal study included 12 patients diagnosed with chronic periodontitis. The periodontal parameters (PlI, GI, PPD, CAL, BOP) and unstimulated saliva of the patients were evaluated at baseline and eight weeks after NSPT. The salivary TAOC and TOS levels were measured using assay kits according to the manufacturer's instructions. Results: At eight weeks after NSPT, the saliva TOS levels were lower and the saliva TAOC levels were higher significantly, compared to those at baseline (p <0.05). A correlation between TAOC and PPD at eight weeks after NSPT was found (p <0.05). Conclusion: The periodontal parameters and oxidative stress biomarkers improved after NSPT when compared to baseline. However, more studies are in need to confirm the correlation between oxidative stress biomarkers and periodontal parameters.
Histopathological features of chronic periapical lesions
Authors:   Faculty of Odonto-Stomatology, University of Medicine and Pharmacy at Ho Chi Minh City, Pham Dieu Linh Thi , Vo Tuyen Dac ,   Department of Oral Pathology, Faculty of Odonto-Stomatology, University of Medicine and Pharmacy at Ho Chi Minh City, Nguyen Kim Chi Thi ,   Department of Oral Pathology, Faculty of Odonto-Stomatology, University of Medicine and Pharmacy at Ho Chi Minh City
Published: September 2023

Chronic periapical inflammation, the sequela of necrotic pulp, is one of the most common diseases in dental practice. The diagnosis of these lesions is based on clinical presentation, radiological features and histopathological examination. The aim of this study was to evaluate the clinico-pathological features of chronic inflammatory periapical lesions. 92 periapical lesions were collected at HCMC Odonto-Stomatology Hospital and HCMC National Odonto-Stomatology Hospital at HCM from June 2019 to January 2020. Male to female ratio was 1:1.6, the age range was 10-70 with average age was 35.5 years old. In terms of clinical features, 30.4% of patients were asymptomatic, 28.3% had percussion sensitivity, 27.2% had swelling, 12% had cortical expansion, 18.5% had intraoral fistula and 3.3% had tooth mobility. The most frequently- involved locations were the anteria maxilla and posterior mandible. Histopathological results confirmed 49 radicular cysts and 43 periapical granulomas. In most cases of radicular cyst (47 cases, 96%), the cyst was lined with nonkeratinized stratified squamous epithelium, with two cases containing mucous cells, 3 cases were observed with cholesterol clefts and 3 cases with Hyaline bodies. In 43 cases of periapical granulomas, the lesions included chronic inflammatory cells and 3 cases with cholesterol clefts. The collagen fibers in fibrous stroma of radicular cysts appeared to be thicker and more linearly arranged while they seemed to be thinner in scattered pattern in periapical granulomas. There was no significant difference between the prevalence of radicular cysts (53.3%) and periapical granulomas (46.7%), no case of chronic periapical abscess was recorded. The ratio of radicular cysts (67.3%) was significantly higher than periapical granulomas (41.9%) at the posterior areas (p<0.05).
Impact of Nucleic Acid Testing (NAT) on screening blood donors at a tertiary center in Vietnam
Authors:   School of Medicine, Vietnam National University, To Kha , Lâm Thị Ngọc Trâm ,   School of Medicine, Vietnam National University, Nguyễn Phương Anh ,   School of Medicine, Vietnam National University, Hồ Tấn Trung ,   School of Medicine, Vietnam National University, Lò Thị Thảo Nguyên ,   School of Medicine, Vietnam National University, Cai Thị Thu Ngân ,   Blood Transfusion Hematology Hospital, Phù Chí Dũng ,   Blood Transfusion Hematology Hospital
Published: September 2023

To ensure safe blood transfusion, since June 2015, Nucleic Acid Testing (NAT) technique has been applied in blood screening process in some areas in Vietnam. The objective of our project is to examine the effectiveness of this technique, to provide specific, updated evidence, as the fundamental for promoting the application of NAT technology in screening blood donors. The study describes a series of cases, performed on 412,705 blood donated samples meeting inclusion criteria at Blood Transfusion Hematology Hospital from January 1, 2017 to January 1, 2019. All collected blood samples were screened for HBV, HCV, and HIV by serology technique, then samples with negative results will continue to be screened by NAT technique. Test results and donor information will be stored on the the hospital’s database. As a result, thanks to NAT screening, our study found 369 more positive blood samples with viral genetic material that serology did not detect, of which: 352 samples reacted with HBV-DNA (0.0871%), 10 samples responded to HCV-RNA (0.0025%) and 6 samples responded to HIV-RNA (0.0017%). Therefore, the application of NAT to the blood screening process is necessary to improve the safety of blood transfusion. Regarding the characteristics of positive cases with infectious agents, we recorded a higher rate of positive for HBV, HIV than men, even when tested by serology or by NAT technique (statistically significant, P <0.05); The positive rate for these 3 agents was higher for first-time blood donors than for repeat blood donors, statistically significant with serological screening (P <, 001) and not statistically significant when screening NAT (P> 0.05). In conclusion, The application of NAT technology in blood screening is essential and effective, improving blood transfusion safety.
Effect of Platelet-Rich Fibrin (PRF) on pain and swelling after surgical removal of impacted lower third molars
Authors:   Odonto-Stomatology department, University of Medicine and Pharmacy, Ho Chi Minh city, Lam Phong Cu , Nguyen Thi Bich Ly ,   Faculty of Odonto-Stomatology, University of Medicine and Pharmacy at Ho Chi Minh City, Nguyen Thi Bao Ngoc ,   Faculty of Odonto-Stomatology, University of Medicine and Pharmacy at Ho Chi Minh City
Published: September 2023

Objectives: The aim of this study is to evaluate the effect of PRF on reducing pain, swelling after surgical removal of impacted lower third molars. Methods: A Randomized, controlled clinical trial and split-mouth design was performed on 26 healthy patients who had indication of impacted lower third molars extrraction on both sides with symmetrically orientation and same difficult index. All patients will have same extraction protocol on both side at department of Oral surgery, Falcuty of Odonto-stomatology, University of medicine and pharmacy. PRF was applied on one side, whereas the other was left empty as the control group. Assessing the pain and swelling level between the experimental and control groups after surgery. Data obtained were statistically analyzed. Results: There is a statistically significant difference in the pain level (p<0.05) on 1st , 3rd and 7th postoperative day between 2 group. Horizontal measurement showed more swelling at the control side (without PRF) on 3rd postoperative day (p<0.05). Conclusion: Using PRF can help reduce pain level after after surgical extraction of impacted lower third molars. PRF seems to be effective on postoperative horizontal swelling and could be used on rountine basic after third molar sugery extraction
Updating recommendations for prescribing antibiotics in dental practice
Authors:   Department of Oral Pathology, Tokyo Medical and Dental University, Japan, Nguyen Phan The Huy , Tran Ngoc Lien ,   Department of Oral Pathology, Faculty of Odonto-Stomatology, University of Medicine and Pharmacy at Ho Chi Minh City, Vietnam
Published: September 2023

According to World Health Organization, antibiotic resistance is one of the alarming global issues requiring the collaboration of different human resources, including clinicians. Based on some countries' recent survey results, there is an increased rate of prescribing antibiotics in dental practice (20%), and most of them are often unnecessary (80%). Some reasons could be cited here are (1) the appearance of some new dental treatments having prophylactic antibiotics, (2) an increase of the aging population, and (3) dentists may be more likely to prescribe an antibiotic while patients wait for the main intervention, etc. Due to this situation, many international and national dental organizations have developed specific recommendations related to the indication and utilization of antibiotics in dental practice. In Vietnam, although there were several alerts and studies concerning antibiotic resistance in dentistry, official and national recommendation has not presented yet. This review aims to synthesize and compare the recommendations of antibiotics prescription in the dental practice of credible professional organizations in certain developed countries in the period of ten years (2011-2020). Besides, we suggest several research directions to provide further scientific evidence to establish specific guidelines for Vietnam's circumstances and improve antibiotic resistance and the community's oral health.
Education Learning Strategies for Combating Stunting in Serdang Village, South Bangka Regency
Authors: Herdiyanti Herdiyanti
Published: September 2023

This social study examines strategies for addressing stunting in Serdang Village, South Bangka Regency. The research employs a descriptive qualitative research method. Serdang Village has experienced a high prevalence of stunting in the past two years, with a slight decrease in recent years. The research findings indicate that the Serdang Village community has actively participated in various awareness-raising activities related to stunting, especially among pregnant and breastfeeding mothers. These activities are conducted by various stakeholders involved in addressing this social issue
First Report of Variable Number of Tandem Repeat Alleles in Phenylalanine Hydroxylase Gene in Patients With Phenylketonuria From Guilan Province, Iran
Authors:   Department of Genetics, Faculty of Biological Sciences, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran., Vakilpour Maryam , Khazaei-Koohpar Zeinab ,   Department of Cellular and Molecular Biology, Faculty of Biological Sciences, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran.
Published: September 2023

Aims Mutations in the phenylalanine hydroxylase (PAH) gene are the main reason for phenylketonuria (PKU). The multiplicity of mutations in the PAH gene, which leads to PKU, makes the diagnosis of pathogenic mutations impossible in many cases. In these cases, polymorphic markers in the PAH gene, such as the variable number of tandem repeats (VNTR) are used to determine the carriers in PKU families. This study aims to investigate the allele frequency of this marker in the PKU population of Guilan Province, Iran. Methods & Materials During one year, 25 unrelated PKU patients were identified from different areas of Guilan Province. After extracting DNA from patients’ blood, VNTR containing fragments of the PAH gene were assessed using the polymerase chain reaction (PCR)-sequencing method. Findings PCR products related to PAH VNTR alleles produced 380, 500, and 530 base pairs fragments. They were related to 3, 7, and 8 copies of the repeat units, respectively. In addition, these repetitions had a frequency of 6(12%), 6(12%), and 33(66%), respectively. Also, this study demonstrated that PKU patients in Guilan Province, Iran had VNTR3/VNTR3, VNTR3/VNTR8, ND/VNTR8, VNTR7/VNTR7, VNTR8/VNTR8, and ND/ND genotypes in the PAH gene. Conclusion This study is the first report on the genetic structure of the PKU population using PAH VNTR alleles in Guilan Province, Iran. Given the population diversity in Iran, it is necessary to study the frequency and distribution of VNTR alleles in different parts of the country.
Investigating the Effect of Vitamin D and Calcium Supplementation Along With High-intensity Circuit Training on Lipid Profile and Body Fat in Overweight Elderly
Authors:   Department of Exercise Physiology, Faculty of Sport Science, University of Tehran, Tehran, Iran., Dalirani Maryam , Gaeini Abbas Ali ,   Department of Exercise Physiology, Faculty of Sport Science, University of Tehran, Tehran, Iran., Kordi Mohammadreza ,   Department of Exercise Physiology, Faculty of Sport Science, University of Tehran, Tehran, Iran.
Published: September 2023

Aims Lifestyle changes, such as dietary modifications and exercise, are highly recommended for managing dyslipidemia. This study aims to investigate the combined effects of high-intensity circuit training along with vitamin D and calcium supplementation on body fat and plasma lipid profiles in overweight elderly. Methods & Materials A total of 47 elderly subjects were randomly divided into 4 groups based on their body mass index as follows: Vitamin D and calcium supplementation+high-intensity circuit training group (D+Ca+T: n=12); high-intensity circuit training+placebo (T+P: n=13); vitamin D and calcium supplementation (D+Ca: n=12); and control group (CON: n=10). The subjects in the D+Ca group respectively received vitamin D and Ca supplements at 50 000 IU per week and 1000 mg per day for 8 weeks. Meanwhile, the subjects in training groups exercised 3 times per week for 8 weeks. The subjects in the D+Ca+T group participated in both treatments. The control group was instructed to maintain their regular daily routine throughout the study period. Body fat and blood lipid levels were assessed at the beginning of the study and after the 8-week intervention. Findings The D+Ca+T, T+P, and D+Ca groups exhibited significant reductions in body fat percentage (P≤0.05), while no significant changes were observed in the control group. Additionally, total cholesterol, triglycerides, High-density lipoprotein cholesterol, and low-density lipoprotein cholesterol significantly improved in the D+Ca+T, T+P, and D+Ca groups (P≤0.05), with no significant changes observed in these variables in the control group. Conclusion The results showed that high-intensity circuit training, vitamin D, and calcium supplementation would positively affect body fat and blood lipid profiles in overweight elderly. Moreover, vitamin D and calcium supplementation were especially effective when combined with exercise training.
Investigating the Effectiveness of Dialectical Behavior Therapy on Resilience, Psychological Flexibility, and Glycemic Control of Diabetic Patients
Authors:   Department of Psychology, Payam Noor University, Tehran, Iran., Aghili Seyed Mojtaba , Farhang Ali ,   Department of Psychology, Faculty of Humanities, Payam Noor University, Gorgan, Iran.
Published: September 2023

Aims Diabetes is a widespread chronic disease that, in addition to affecting the individual’s clinical condition, imposes high costs on societies worldwide. This study aims to investigate the effectiveness of dialectical behavior therapy on the resilience, psychological flexibility, and glycemic control of diabetic patients. Methods & Materials This research was practical in purpose and semi-experimental in method with a pre-test/post-test design with a control group. The statistical population comprised all people with diabetes who were referred to Sayad Hospital in Gorgan City, Iran, in 2022. From this statistical population, 30 patients were selected via the available sampling method and randomly divided into an experimental (n=15) and a control group (n=15). The experimental group was trained in dialectical behavior therapy, while the control group did not receive any psychological intervention during the implementation of the research. The research tool was the Connor and Davidson resilience questionnaire (2003) and the Dennis psychological flexibility questionnaire (2010). Research data were analyzed by multivariate covariance analysis using the SPSS software, version 24. Findings The Mean±SD of the post-test total score of resilience, psychological flexibility, and glycemic control in the experimental group were respectively 80.60±20.62, 91.00±25.64, and 198.10±26.52. These numbers were respectively 77.20±22.86, 75.60±22.29, and 204.30±30.18 for the control group. Dialectical behavior therapy had a significant effect on the resilience, flexibility, and glycemic control of diabetic patients (P<0.05). Conclusion By performing mindfulness exercises and emotional experience modulation, dialectical behavioral therapy training has led to the promotion of mental health, improvement of resilience skills, and flexibility of diabetic patients. Therefore, this method can be used as a new approach to increase the self-care skills of patients with diabetes in health-related centers.
Synthesis and Characterization of Ciprofloxacin-loaded Chitosan Nanoparticles for Eradication of Pseudomonas aeroginosa Biofilm
Authors:   Department of Microbiology, Faculty of Science, Agriculture and New Technologies, Shiraz Branch, Islamic Azad University, Shiraz, Iran., Faridi Foroogh , Bahador Nima ,   Department of Microbiology, Faculty of Science, Agriculture and New Technologies, Shiraz Branch, Islamic Azad University, Shiraz, Iran., Shoja Saeed ,   Infectious and Tropical Diseases Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran., Abbasi Sahar ,   Department of Pharmaceutics, Faculty of Pharmacy, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
Published: September 2023

Background: Pseudomonas aeruginosa biofilm is one of the problems in antibiotic treatment of infections. Nanomedicines, such as chitosan (CS) can carry multiple drugs and improve the therapeutic effects of antibiotics. Objectives: This study aimed at the synthesis and characterization of ciprofloxacin-loaded chitosan nanoparticles for eradication of P. aeroginosa biofilm. Methods: Cipro-CS microparticles were prepared by ionic gelation method and their size, zeta potential, and drug release pattern were determined. MBEC and MBIC of different groups of antibiotics (ciprofloxacin, ciprofloxacin-PAβN, CS ciprofloxacin, and CS ciprofloxacin-PAβN) were performed on biofilm samples of P. aeroginosa. Results: Ciprofloxacin loading efficiency was 35.51%, and encapsulation efficiency was 55.06%. Released ciprofloxacin from CS nanoparticles was 80% after 24 hours. Biofilm production was positive in 96.7% of the isolates while 30.1% of the samples had strong biofilm. The best result for MBIC was CS ciprofloxacin, CS ciprofloxacin-PAβN, ciprofloxacin- PAβN, and ciprofloxacin, respectively. For MBEC the result was slightly different and from the best to better CS Ciprofloxacin-PAβN, CS Ciprofloxacin, Ciprofloxacin-PAβN, and ciprofloxacin. Conclusion: Today, with increasing antibiotic resistance, there are many challenges in treating infections. Due to the role of biofilm in antibiotic resistance, researchers are looking for new antibiotics to treat infections.
Minocycline Prevents Depression-like Behavior After Co-administration With Dexamethasone or Cyclosporine-A in Mice
Authors:   Department of Pharmacology and Toxicology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran., Mesripour Azadeh , Pezeshki Sara ,   Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
Published: September 2023

Background: In animal studies, minocycline (Mcy) has been proven to have antidepressant effects. In addition to modulating peripheral and central pro-inflammatory pathways, Mcy may regulate the hypothalamic-pituitary-adrenal (HPA) axis and the mechanistic target of rapamycin (mTOR) signaling pathway. This study aims to evaluate the antidepressant-like effect of Mcy in mice following injection of dexamethasone (Dex) or cyclosporine-A (CsA). Methods: Male NMRI mice were randomly divided into eight groups of 6, including control, Dex 0.25 mg/kg, CsA 20 mg/kg, Mcy 40 mg/kg, Dex+Mcy, Dex+fluoxetine 20 mg/kg, CsA+Mcy, and CsA+fluoxetine. All drugs were injected intraperitoneally (except for Dex, which was subcutaneous injection) once daily for 3 days. The locomotor activity, forced swimming test (FST), and sucrose preference (SP) test were performed on day 4. Results: Mcy alone reduced immobility time in the FST (27.0±6.4 s) compared to the control group (104±3.9 s) (P<0.001). After the co-administration of Mcy and Dex, the immobility time significantly decreased (79.5±6.5 s) compared to the Dex group (P<0.001). It also decreased following the co-administration of Mcy and CsA (67.5±20.8 s) compared to the CsA group (P<0.001). Results were similar in the groups treated with fluoxetine plus Dex or CsA. Significant differences were not observed in the locomotor activity test. Conclusion: Mcy prevents depression-like behavior in mice during the FST when it is co-administrated with CsA or Dex. The possibility of the positive effect of Mcy on the HPA axis and the mTOR signaling pathway should be examined in further studies.
Factors related to Helping Behavior in Guilan Welfare Organization
Authors:   Ph.D in Medical Sociology, Department of Social Sciences, Faculty of Literature and Humanities, Gilan University, Rasht, Iran., Masoudnia Ebrahim
Published: September 2023

Introduction: The aim of this study was to identify the factors affecting the reduction of citizens' helping behavior with the welfare organization. Method: This study was conducted by descriptive method and ex-post facto design. Data were collected from 408 citizens whose age was 20 years and older, and they all were from Guilan province. Samples were selected using multistage cluster sampling method. Measurement tools were: Adult Trust Scale; Multidimensional Perceived Social Support Scale; Norm of Reciprocity Scale; Social Network Index; Social Responsibility Questionnaire; Sense of Empathy Questionnaire; Revised Citizen Participation in Decision Making Questionnaire; Organizational Transparency Questionnaire; Awareness of Cooperation Methods and Level of Cooperation Questionnaire. Findings: Significant differences between individuals with poor, moderate, and high helping in terms of social trust; social support; social networks and ties; norm of reciprocity; norm of social responsibility; sense of empathy; belief in not involving citizens in the decisions of the welfare organization; citizens' awareness of cooperation methods; belief in the lack of transparency in the performance of the welfare organization; and altruistic behavior was observed. Discussion: Inadequacies in social variables act as risk factors for reducing cooperation with the welfare organization. Therefore, it is necessary to take intervention measures to strengthen psychosocial variables in order to improve the level of cooperation of citizens.
Designing the Pathology Model of Public Welfare Governance in Iran
Authors:   Ph.D. in Health Economics, Health Management and Economics Research Center, Iran University of Medical Sciences, Tehran, Iran, Ghorbani Salar , Olfatpour Nadali ,   Ph.D. student in Public Administration, Faculty of Management and Economics, Islamic Azad University, Tehran Science and Research Unit, Tehran, Iran., Mousakhani Morteza ,   Ph.D. in Public Administration, Faculty of Management and Economics, Islamic Azad University, Tehran Science and Research Unit, Tehran, Iran., Olfatpour Mohammadamin ,   Bachelor of Laws, Islamshahr Islamic Azad University, Tehran, Iran
Published: September 2023

Introduction: Policymakers' inability to identify and analyze public issues to formulate necessary policies, the weaknesses of agents and executives in implementing the procedures, and the lack of optimal use of existing resources are among the most prominent disadvantages of public welfare governance in various societies. The purpose of this research is to provide a model to understand the inefficiency of public welfare governance in Iran. Method: The present research is a mixed-method type (quantitative-qualitative) of research. In order to identify the concepts, dimensions and indicators of the model, theme analysis (qualitative) was used, and structural equation modeling (quantitative) was employed to fit the conceptual model of the research. 26 experts, professors and experts in the field of policy and public welfare have been selected for the socio-statistics of the qualitative part. The statistical population of the quantitative part consists of 240 experts, managers and senior managers in the field of policy and social welfare. 148 people participated considering Cochran's formula. Findings: In the qualitative part; 50 initial indicators were identified and after coding, 45 indicators were confirmed by theme analysis. Six dimensions (management and decision-making; public finance of the government; planning; internal environment; external environment and sectoral governance), and four components of causal, contextual, strategy, and consequence factors were confirmed. In the quantitative part, the dimensions of management and decision-making and public finance of the government were found to have an effect on the dimensions of the internal and external environment as well as on the dimension of planning, and the dimension of planning also affects the governance of a sector. The dimension of management and decision-making was ranked first with an average of 6.54, and the dimension of governance was ranked last with an average of 5.14. Discussion: A comprehensive model for identifying public issues enables the country to determine and implement priorities and strategies. The design requirements for the pattern of public welfare pathology in Iran will be six dimensions and 45 indicators extracted in this model.
Qualitative and quantitative analysis of porphyrin films surface morphology
Authors:   Peter the Great St. Petersburg Polytechnic University, Bekov D. U. , Zakharova I. B. ,   Peter the Great St. Petersburg Polytechnic University, Romanov N. M. ,   JSC Svetlana-Semiconductors,   LUT University, Elistratova M. A. ,   Ioffe Institute
Published: September 2023

The surface morphology of tetraphenylporphyrin thin polycrystalline films – H2TPP and ZnTPP obtained by vacuum condensation under quasi-equilibrium conditions is analyzed by sc. The use of analytical methods for processing images of the organic films surface obtained by standard methods, allows to identify not only qualitative, but also quantitative characteristics of the polycrystalline films structure: the average grain size, grain size distribution, the presence of texture and characteristic of crystallites orientations. It is shown that free based H2TPP tetraphenylporphyrin films have a more pronounced texture and a larger crystallite size than ZnTPP, which is due to the peculiarities of self-organization of molecules, if condensation occurs under the same conditions. The applicability of this method of image analysis for obtaining information about the structure and morphology of the surface of thin organic films during vacuum condensation is shown.
Environmental Factors Associated with Incidence of Stunting in Toddlers: Literature Review
Authors: Nur Amalia Ilmy , Setiani Onny , Hanani Darundati Yusniar
Published: September 2023

Stunting is a public health problem that receives special attention because it is related to human resources in the future. Many studies state that stunting is related to nutritional problems in toddlers, only a few studies show that environmental factors are an indirect cause of stunting in toddlers. The purpose of this systematic study was to describe the relationship between environmental factors and the incidence of stunting in toddlers.  This literature study used a scoping review method by searching through several search engines such as Scopus and nature and science direct databases supported by Diponegoro University.  The articles selected for review are articles that contain the results of observational studies (cross-sectional, cohort and case control) that analyze environmental factors with the incidence of stunting in toddlers. From 7 articles, only 1 study stated that environmental factors did not affect the incidence of stunting, 6 other articles stated that environmental factors were an indirect cause of stunting in toddlers. Environmental factors related to stunting are the source of drinking water, the practice of haphazard defecation, the presence of animal waste in the living environment, environmental enteric dysfunction, the availability of proper toilet, the practice of washing hands with soap when feeding children, exposure to cigarette smoke, exposure to PM 2.5, household waste and clean and healthy living behavior.
Analisis Kualitas Air Minum dan Risiko Kesehatan Lingkungan Pencemaran Besi (Fe) Sumur Gali di Perumahan Dosen Kecamatan Kambu, Kendari
Authors: Nurmayang Sari Sitti , Juhanda S Wa Ode Risna , Juraiti Warti , Oktaviani Salydin Oky , Nurwiwin Nurwiwin , Yasin Asramid , Tosepu Ramadhan , Muhammad Erif La Ode
Published: September 2023

Salah satu sumber penyediaan air yaitu dari sumur gali yang dimanfaatkan masyarakat sebagai air bersih maupun air minum, namun seringkali memiliki kandungan Fe. Permenkes No. 32 (PMK) Tahun 2017 mengatur tentang batas maksimal kandungan Fe untuk air minum dan dan air bersih yaitu 1 mg/L. Penelitian ini bertujuan untuk mengetahui tingkat konsentrasi Fe pada sumur Gali Perumahan Dosen Kecamatan Kambu Kota Kendari, disesuaikan dengan ketentuan batas maksimal pada PMK No.32 Tahun 2017 yaitu 1 mg/L. Penelitian ini juga bertujuan melihat dampak lingkungan pencemaran Fe pada air sumur gali di Perumahan Dosen. Penelitian ini menggunakan metode kuantitatif berbasis analisis spektrofotometri. Pengukuran kandungan Fe yang terdapat pada 3 sampel air kemudian dibandingkan dengan standar standar maksimal Fe pada air minum mengacu pada PMK No.32 Tahun 2017 dan desain studi (ARKL). Populasi penelitian yaitu seluruh penduduk yang memanfaatkan sumur gali berdasarkan teknik purposive sampling yaitu masyarakat yang telah menetap selama 3 tahun. Teknik pengambilan data menggunakan kuesioner dan wawancara. Hasil penelitian konsentrasi Fe dari 3 titik lokasi menunjukkan bahwa konsentrasi Fe masih berada dibawah nilai maksimal 1 mg/L. Dampak kesehatan non-karsinogenik paparan Fe menunjukkan bahwa karakteristik dampak (RQ) dari keseluruhan sampel uji adalah 1, dimana sumur tersebut masih aman untuk dikonsumsi oleh masyarakat.
Prediksi Kecepatan Angin Jangka Menengah dengan Artificial Neural Network untuk Estimasi Daya Listrik Tenaga Angin (Studi Kasus: Kota Sabang)
Authors: Malek Abdul , Suriadi Suriadi , Saddami Khairun
Published: September 2023

Indonesia, as a country at the equator, has a very large renewable energy potential that can be used as a source of electrical energy. Electricity consumption in Indonesia, especially in Aceh, continues to increase annually because of population growth and increasing economic needs. Recently, the construction of power plants has been considered to be environmentally friendly and economical. One of the efforts that can be made is the development of wind-power plants. The availability of certain wind speeds was expected. Therefore, accurate prediction data must be used as the basis for building wind power plants. To increase the accuracy of wind speed prediction by looking at the error rate in predicting the amount of wind speed generated using an Artificial Neural Network with feed-forward and feed-backward functions from the back propagation algorithm (BPNN). The results of the application using the Neural Network algorithm with a back propagation Neural Network (BPNN) to predict wind speed show that the Neural Network algorithm can predict wind speed with an error of 0.0036. In July 2021, the estimated energy demand is 81.5 KWH.
Analisis Kuat Tekan Beton Menggunakan Bahan Substitusi Serat Roving dan Cangkang Tiram
Authors: Bunyamin Bunyamin , Hady Munirul , Hendrifa Nesri , Syakir Ahmad
Published: September 2023

Para peneliti telah melakukan percobaan terhadap bahan-bahan lain yang sifatnya sama seperti semen, seperti limbah cangkang tiram. Hasil penelitian terdahulu menunjukkan bahwa penggantian semen 10% dan FAS (Faktor Air Semen) 0,50 mampu meningkatkan kuat tekan beton. Pada penelitian ini, akan ditambahkan material lain ke dalam semen tersebut yaitu serat roving (serat gypsum), bertujuan mengurangi retak yang terjadi. Tujuan penelitian ini adalah untuk memanfaatkan limbah cangkang tiram sebesar 10% dan penambahan serat roving sebesar 5%, 10%, dan 15% ke dalam semen terhadap kuat tekan beton. Benda uji berupa silinder (15 cm x 30 cm) berjumlah 20 unit. Limbah cangkang tiram berasal dari Krueng Neng, Aceh Besar. Serat roving didapatkan dari toko bahan bangunan di Banda Aceh. Penelitian ini dilaksanakan berdasarkan metode ACI 211.1-91 (American Concrete Institute) dan ASTM (American Society for Testing and Material). Hasil penelitian menunjukkan bahwa kuat tekan beton normal sebesar 22,05 MPa. Sedangkan kuat tekan beton dengan substitusi serat roving dan cangkang tiram adalah 25,16 MPa, 30,59 MPa, dan 30,70 MPa. Kuat tekan beton yang dikombinasikan meningkat dibandingkan dengan kuat tekan beton normal.
Review : Sintesis Zeolit dari Bahan Alam dan Limbah Buangan
Authors: Fitriyah Fitriyah , Krisnandi Yuni Krisyuningsih
Published: September 2023

Penggunaan zeolit memerlukan biaya yang relatif tinggi untuk sintesis pembuatan zeolitnya. Oleh karena itu perlu adanya alternatif bahan dasar pembuatan zeolit, yang dapat mengurangi biaya preparasi dan sintesis zeolit. Salah satu alternatif sintesis zeolit berasal dari limbah buangan dan bahan alam. Keuntungan lainnya menggunakan bahan alam dan limbah buangan yaitu sebagai salah satu usaha untuk menyelesaikan permasalahan lingkungan. Â Berdasarkan jurnal tersebut beberapa bahan menggunakan bahan yang berbeda serta metode dan parameter yang berbeda juga namun menunjukkan hasil sintesis yang signifikan dalam pembuatan zeolit sintesis yang dapat diaplikasikan terhadap lingkungan sebagai adsorben
Performance Assessment of Single Flash PLTP LMB 1 After First Year Inspection Using ASME PTC 46:1996 Method
Authors: Simatupang Joni Welman , Solihat Asep Mamat Rahmat
Published: September 2023

PLTP LMB 1 performs a First-Year Inspection after operating for one year to inspect and repair equipment after the operation. After these activities, a performance test needs to be carried out to determine the effectiveness and success of these activities. ASME PTC 46: 1996 is a widely-used standard for analyzing the performance test of thermal power plant systems, which includes plant heat rate, power output, specific mass consumption, and more. The purpose of the testing is to evaluate the results of system improvements. Calculation and comparative analysis are performed to determine the system's condition during warranty, commissioning, and testing, as well as after one year of operation and post-first year inspection. After testing, the thermal performance of PLTP LMB 1 was obtained as follows: The corrected net plant heat rate (NPRH) was 18923 kJ/kWh, the corrected net power output was 56,417 MW, and the net specific mass consumption (NSMC) was 6,881 tons/MW. Based on the data guarantee, the thermal performance value of PLTP LMB1 is still below the required value, so it can be concluded that the thermal performance value of PLTP LMB1 is in good condition. The isentropic turbine efficiency value decreased by 2.1% from its design value of 85% to 82.9%, which was caused by suboptimal heat energy absorption by the turbine above the design pressure of 5 bar.
Evaluasi Perbandingan Gas Buang Hasil Pengolahan Sampah Domestik Menggunakan Teknologi Termal
Authors: Putra Rizki Kurnia , Hendrasarie Novirina
Published: September 2023

Kuantitas limbah padat domestik berbanding lurus dengan kenaikan jumlah penduduk. Pengumpulan dan pembuangan limbah memerlukan sistem pengelolaan limbah padat yang bersih dan efektif. Sistem pengelolaan limbah padat yang efisien biasanya akan tumbuh sebanding dengan ukuran pemukiman dan pendapatan per kapita penduduk. Teknologi pembakaran limbah kota memegang peranan penting dalam mengolah dan juga memampatkan produksi limbah pemukiman/perkotaan. Hal tersebut dikarenakan selain berperan dalam proses penyusutan volume limbah padat, teknologi pembakaran yang sesuai adalah insinerasi dan gasifikasi. Penelitian ini bertujuan untuk melakukan evaluasiÂ  perbandingan gas buang hasil pengolahan sampah domestik menggunakan teknologi termal insinerasi dan gasifikasi. Metode penelitian yang dilakukan adalah dengan melakukan uji emisi pada insinerasi dan gasifikasi dengan variasi sampah biodegradable, non-biodegradable, dan campuran. Hasil yang didapatkan adalah Kadar CO terendah adalah variabel biodegradable 100 Kg pada insenerasi dengan nilai 31,86 mg/Nm3. NOx terendah adalah variabel biodegradable 100 Kg pada Insinerasi dengan nilai 63,22 mg/Nm3. HCl terendah adalah variabel biodegradable 100 Kg pada Insinerasi dengan nilai 12,53 mg/Nm3. SO2 terendah adalah variabel biodegradable 100 Kg pada Insenerasi dengan nilai 40,63 mg/Nm3.
Perancangan Ulang Tata Letak Pabrik Industri Olahan Rotan PT XYZ di Kabupaten Cirebon Menggunakan Metode Systematic Layout Planning
Authors: Adib Jachsyun , Subagyo Ade Momon , Sari Rianita Puspa
Published: September 2023

Pabrik industri olahan rotan PT XYZ merupakan salah satu pabrik industri rotan yang berdiri sejak tahun 2000, dengan fokus pada salah satu rangkaian produksi produk rotan yaitu finishing. Tata letak pabrik saat ini belum terorganisir dengan sistematik dan belum ada perancangan khusus didalamnya. Hal ini tergambar pada terdapatnya cross movement, laju backtracking, tingginya ongkos material handling,dan juga terlalu jauh jarak antar departemen yang berkaitan langsung secara aliran proses produksi. Penelitian ini bermaksud untuk melakukan perancangan ulang terhadap tata letak pabrik untuk mendapatkan ongkos material handling dan jarak perpindahan material yang lebih minimum, pada penelitian ini menggunakan metode Systematic Layout Planning (SLP). Akan diusulkan tata letak yang dapat memangkas ongkos material handling lebih minim dan jarak perpindahan barang lebih dekat dengan tidak adanya masalah dalam aliran proses. Hasil penelitian ini didapat layout usulan baru yang memiliki ongkos material handling Rp1.183.614 per minggu dengan pengurangan nilai sebesar Rp476.906 atau 28,72% dan tidak terdapat masalah.
Perancangan Chasis Prototype Mobil Listrik Jenis Pick Up untuk Kebutuhan Kendaraan di Pedesaan
Authors: Ramadhani Hendi , Marno Marno , Oleh Oleh
Published: September 2023

Mobil listrik saat ini berkembang sangat pesat dengan berbagai inovasi yang terus dilakukan. Hal ini dinilai untuk menggantikan bahan bakar fosil untuk kendaraan manusia. Salah satu komponen penting yang perlu diperhatikan dalam rancangan mobil listrik adalah rangka atau chasis. Penelitian ini ditujukan untuk merancang chasis prototype untuk mobil listrik berjenis pick up untuk kebutuhan di pedesaan. Rancangan ini menggunakan pendekatan statistik dan menggunakan bantuan simulasi pada software solidworks. Berdasarkan hasil analisis simulasi didapatkan material AISI 1020 yang dinilai paling tepat untuk rangka yang dirancang. Didapatkan nilai stress sebesar , displacement sebesar , dan safety factor sebesar 2,5. Pemilihan AISI 1020 sebagai material chassis prototype kendaraan listrik berjenis pick up untuk keperluan kendaraan di perdesaan karena material ini merupakan baja karbon rendah dengan kekuatan sedang yang umumnya digunakan dalam konstruksi mekanis dan kemampuan pengelasan yang baik. Material AISI 1020 sering digunakan dalam pembuatan chassis mobil karena biayanya yang lebih rendah, kemudahan pengolahan yang baik, memiliki kekuatan dan daktilitas tinggi.
Adsorpsi Zat Pewarna Metilen Biru Menggunakan Karbon Berpori Teraktivasi NaOH
Authors: Mistar Eka Marya , Amni Chairul , Zein Ikramullah , Maulinda Maulinda , Zulfikar Teuku Muhammad , Hasmita Ida
Published: September 2023

Metilen biru (MB) merupakan suatu zat pewarna yang sering digunakan pada proses pewarnaan kapas, kayu dan sutra. Tetapi pembuangan air limbah berwarna tanpa pengolahan yang tepat dapat mengakibatkan berbagai masalah lingkungan. Penggunaan biosorben yang berbeda sebagai adsorben berbiaya rendah alternatif dalam menghilangkan MB telah dipelajari dan dikaji secara luas, termasuk kapasitas adsorpsi dan kondisi eksperimentalnya. Penelitian ini bertujuan untuk mengetahui adsorpsi methylene blue pada karbon aktif. Dalam penelitian ini, karbon aktif yang diproduksi dari bambu kuning teraktivasi NaOH digunakan sebagai biosorben untuk menyerap MB dari media berair. Karbon aktif dimasukkan ke dalam kolom unggun tetap dengan variasi laju alir larutan MB yaiut 5 mL/menit dan 10 mL/menit. Hasil adsorpsi mengindikasikan bahwa daya serap MB tertinggi yaitu 8.23 mg/L pada laju alir 5 mL/menit pada waktu adsorpsi menit ke 100.
Analisis Safety stock dan Reorder point Persediaan Bahan Baku Produk Barside K-59 di PT. XYZ
Authors: Bawono Nangkulo Ika , Erik Asep
Published: September 2023

PT. XYZ merupakan perusahaan engineering yang bergerak di bidang fabrication, machining, dan part stamping. Beberapa jenis material diperlukan untuk mempertahankan kelangsungan fungsi pabrik atau fasilitas lainnya. Untuk mencapai keuntungan maksimum, perusahaan harus memperhatikan persediaan yang dipelihara untuk mengurangi risiko tidak dapat memenuhi kebutuhan pelanggan dan potensi bahaya lainnya, seperti ketidakpuasan pelanggan terhadap kemampuan dan layanan perusahaan. Karena mengelola inventaris perusahaan memiliki dampak yang signifikan terhadap sejumlah biaya inventaris, seperti biaya pembelian, biaya pemesanan, biaya penyimpanan, dan biaya kekurangan, perusahaan harus menjaga tingkat inventaris yang tepat di gudang mereka dalam bentuk bahan baku untuk aktivitas produksi yang tepat. Berbagai metode yang digunakan dalam upaya pengendalian persediaan memiliki tujuan agar meminimalkan kemungkinan-kemungkinan buruk yang akan datang dan tidak diinginkan oleh perusahaan, oleh karena itu metode safety stock dan reorder point, dirasa tepat untuk menjawab permasalahan yang ada pada perusahaan. Nilai safety stock yang dibutuhkan oleh perusahaan sebelum dilakukannya reorder point berkisar antara 0 âˆ’ 139 unit sedangkan Nilai reorder point yang dibutuhkan sebelum mengalami kehabisan bahan baku berkisar antara 1606 âˆ’ 1745 unit.
Studi Literatur Keanekaragaman Hayati Tumbuhan Asli Rawa Tripa yang Berpotensi Sebagai Tumbuhan Obat
Authors: Yulisma Ardhana , Fathiya Nir
Published: September 2023

Indonesia merupakan negara dengan tingkat keanekaragaman flora dan fauna tertinggi di dunia nomor dua setelah Brasil. Dalam dunia flora, diperkirakan terdapat ± 40.000 spesies tumbuhan dan 40% diantaranya bersifat endemik. Sementara itu, diperkirakan terdapat 2500-3000 tumbuhan yang memiliki potensi sebagai tumbuhan obat. Rawa Tripa merupakan salah satu hutan gambut terbesar yang berada di Aceh. Diperkirakan terdapat banyak jenis tumbuhan di Rawa Tripa yang berpotensi sebagai tumbuhan obat. Penulisan artikel ini bertujuan untuk mengetahui keanekaragaman hayati tumbuhan asli Rawa Tripa yang berpotensi sebagai tumbuhan obat berdasarkan studi kepustakaan. Artikel ini merupakan studi literatur dengan menggunakan data sekunder yang bersumber pada karya ilmiah dan literatur-literatur terkini. Hasil diskusi menjelaskan bahwa terdapat 31 spesies tumbuhan asli Rawa Tripa yang memiliki potensi sebagai tumbuhan obat tradisional menurut laporan literatur terkini. Sementara itu, tumbuhan Chilocarpus suaveolens, Palaquium ridleyi, Brackenridgea palustris, Gynotroches axillaris, Gardenia tubifera, dan Knema intermedia belum ada literatur yang melaporkan tentang potensi tumbuhan tersebut sebagai tumbuhan obat. Sejalan dengan Cyrtostachys lakka Becc. yang merupakan Non Tumbuhan Obat (Non TO), dimana tumbuhan ini dipercaya oleh sebagian masyarakat Indonesia dapat menangkal malapetaka.
Penilaian Teknis Tempat Pengelolaan Sampah di TPST Taman Kabupaten Sidoarjo Jawa Timur
Authors: Karami Abdillah Akmal , Auvaria Shinfi Wazna
Published: September 2023

Tempat Pengolahan Sampah Terpadu (TPST) adalah fasilitas pengolahan sampah yang dirancang untuk menerima, memproses, dan mengelola sampah yang berasal dari berbagai sumber. Tujuan fasilitas ini adalah untuk mengurangi dampak buruk sampah terhadap lingkungan dan kesehatan manusia. Jumlah sampah yang masuk ke TPST Taman terus meningkat, yang mengakibatkan penurunan beberapa fasilitas dan teknik pengelolaan sampah. Tujuan dari penelitian ini adalah untuk menghitung jumlah timbulan, densitas, volume, dan komposisi sampah. Selain itu, untuk menilai kesesuaian TPST Taman dengan Permen PU No.03 Tahun 2013. Menurut SNI 19-3964-1994, metode penghitungan volume digunakan untuk menghitung laju timbulan sampah. Hasil penelitian menunjukkan timbulan sampah rumah tangga sebesar 0,068 kg/hari, dengan sampah yang dapat dikomposkan, plastik, dan kertas yang paling banyak. Sampah memiliki densitas 395,67 kg/m3. Hasil penilaian aspek teknis pengelolaan sampah di TPST Taman Sidoarjo, yang dilakukan berdasarkan Permen PU No.03 Tahun 2013, menunjukkan bahwa hanya satu aspek yang memenuhi kriteria penempatan TPST berada didalam kota.