bluuebunny/crossref_metadata_2025 huggingface dataset:
Photomobile Polymer Materials with Crosslinked Liquid‐Crystalline Structures: Molecular Design, Fabrication, and Functions
Authors: Ube Toru , Ikeda Tomiki
Published: September 2014

Crosslinked liquid‐crystalline polymer materials that macroscopically deform when irradiated with light have been extensively studied in the past decade because of their potential in various applications, such as microactuators and microfluidic devices. The basic motions of these materials are contraction–expansion and bending–unbending, which are observed mainly in polysiloxanes and polyacrylates that contain photochromic moieties. Other sophisticated motions such as twisting, oscillation, rotation, and translational motion have also been achieved. In recent years, efforts have been made to improve the photoresponsive and mechanical properties of this novel class of materials through the modification of molecular structures, development of new fabrication methods, and construction of composite structures. Herein, we review structures, functions, and working mechanisms of photomobile materials and recent advances in this field.
Exploring Weak Ligand–Protein Interactions by Long‐Lived NMR States: Improved Contrast in Fragment‐Based Drug Screening
Authors: Buratto Roberto , Mammoli Daniele , Chiarparin Elisabetta , Williams Glyn , Bodenhausen Geoffrey
Published: September 2014

Ligands that have an affinity for protein targets can be screened very effectively by exploiting favorable properties of long‐lived states (LLS) in NMR spectroscopy. In this work, we describe the use of LLS for competitive binding experiments to measure accurate dissociation constants of fragments that bind weakly to the ATP binding site of the N‐terminal ATPase domain of heat shock protein 90 (Hsp90), a therapeutic target for cancer treatment. The LLS approach allows one to characterize ligands with an exceptionally wide range of affinities, since it can be used for ligand concentrations [L] that are several orders of magnitude smaller than the dissociation constantsKD. This property makes the LLS method particularly attractive for the initial steps of fragment‐based drug screening, where small molecular fragments that bind weakly to a target protein must be identified, which is a difficult task for many other biophysical methods.
Enantioselective Synthesis of Piperidines through the Formation of Chiral Mixed Phosphoric Acid Acetals: Experimental and Theoretical Studies
Authors: Sun Zhankui , Winschel Grace A. , Zimmerman Paul M. , Nagorny Pavel
Published: September 2014

An enantioselective intramolecular chiral phosphoric acid‐catalyzed cyclization of unsaturated acetals has been utilized for the synthesis of functionalized chiral piperidines. The chiral enol ether products of these cyclizations undergo subsequent in situ enantioenrichment through acetalization of the minor enantiomer. A new computational reaction exploration method was utilized to elucidate the mechanism and stereoselectivity of this transformation. Rather than confirming the originally postulated cyclization proceeding directly through a vinyl oxocarbenium ion, simulations identified an alternative two‐step mechanism involving the formation of a mixed chiral phosphate acetal, which undergoes a concerted, asynchronous SN2′‐like displacement to yield the product with stereoselectivity in agreement with experimental observations.
Organic Dicarboxylate Negative Electrode Materials with Remarkably Small Strain for High‐Voltage Bipolar Batteries
Authors: Ogihara Nobuhiro , Yasuda Tomomi , Kishida Yoshihiro , Ohsuna Tetsu , Miyamoto Kaito , Ohba Nobuko
Published: September 2014

As advanced negative electrodes for powerful and useful high‐voltage bipolar batteries, an intercalated metal–organic framework (iMOF), 2,6‐naphthalene dicarboxylate dilithium, is described which has an organic‐inorganic layered structure of π‐stacked naphthalene and tetrahedral LiO4 units. The material shows a reversible two‐electron‐transfer Li intercalation at a flat potential of 0.8 V with a small polarization. Detailed crystal structure analysis during Li intercalation shows the layered framework to be maintained and its volume change is only 0.33 %. The material possesses two‐dimensional pathways for efficient electron and Li+ transport formed by Li‐doped naphthalene packing and tetrahedral LiO3C network. A cell with a high potential operating LiNi0.5Mn1.5O4 spinel positive and the proposed negative electrodes exhibited favorable cycle performance (96 % capacity retention after 100 cycles), high specific energy (300 Wh kg−1), and high specific power (5 kW kg−1). An 8 V bipolar cell was also constructed by connecting only two cells in series.
Identification of Hypoxic Cells Using an Organotellurium Tag Compatible with Mass Cytometry
Authors: Edgar Landon J. , Vellanki Ravi N. , Halupa Adrienne , Hedley David , Wouters Bradly G. , Nitz Mark
Published: September 2014

Mass cytometry (MC) offers unparalleled potential for the development of highly parameterized assays for characterization of single cells within heterogeneous populations. Current reagents compatible with MC analysis employ antibody‐metal‐chelating polymer conjugates to report on the presence of biomarkers. Here, we expand the utility of MC by developing the first activity‐based probe designed specifically for use with the technology. A compact MC‐detectable telluroether is linked to a bioreductively sensitive 2‐nitroimidazole scaffold, thereby generating a probe sensitive to cellular hypoxia. The probe exhibits low toxicity and is able to selectively label O2‐deprived cells. A proof‐of‐concept experiment employing metal‐bound DNA intercalators demonstrates that a heterogeneous mixture of cells with differential exposure to O2 can be effectively discriminated by the quantity of tellurium‐labeling. The organotellurium reagents described herein provide a general approach to the development of a large toolkit of MC‐compatible probes for activity‐based profiling of single cells.
Palladium(0)‐Catalyzed Heck Reaction/CH Activation/Amination Sequence with Diaziridinone: A Facile Approach to Indolines
Authors: Zheng Huaiji , Zhu Yingguang , Shi Yian
Published: September 2014

Indolines are important moieties present in various biologically significant molecules and have attracted considerable attention in synthetic chemistry. This paper describes a Heck reaction/CH activation/amination sequence for forming indolines using di‐tert‐butyldiaziridinone. The reaction process likely proceeds via a pallada(II)cycle, which is converted into an indoline by oxidative addition to the diaziridinone and two subsequent CN bond formations.
Towards Chemical Communication between Gated Nanoparticles
Authors: Giménez Cristina , Climent Estela , Aznar Elena , Martínez‐Máñez Ramón , Sancenón Félix , Marcos M. Dolores , Amorós Pedro , Rurack Knut
Published: September 2014

The design of comparatively simple and modularly configurable artificial systems able to communicate through the exchange of chemical messengers is, to the best of our knowledge, an unexplored field. As a proof‐of‐concept, we present here a family of nanoparticles that have been designed to communicate with one another in a hierarchical manner. The concept involves the use of capped mesoporous silica supports in which the messenger delivered by a first type of gated nanoparticle is used to open a second type of nanoparticle, which delivers another messenger that opens a third group of gated nanoobjects. We believe that the conceptual idea that nanodevices can be designed to communicate with one another may result in novel applications and will boost further advances towards cooperative systems with complex behavior as a result of the communication between simple abiotic individual components.
Concise and Enantioselective Total Synthesis of (−)‐Mehranine, (−)‐Methylenebismehranine, and Related Aspidosperma Alkaloids
Authors: Mewald Marius , Medley Jonathan William , Movassaghi Mohammad
Published: September 2014

We report an efficient and highly stereoselective strategy for the synthesis of Aspidosperma alkaloids based on the transannular cyclization of a chiral lactam precursor. Three new stereocenters are formed in this key step with excellent diastereoselectivity due to the conformational bias of the cyclization precursor, leading to a versatile pentacyclic intermediate. A subsequent stereoselective epoxidation followed by a mild formamide reduction enabled the first total synthesis of the Aspidosperma alkaloids (−)‐mehranine and (+)‐(6S,7S)‐dihydroxy‐N‐methylaspidospermidine. A late‐stage dimerization of (−)‐mehranine mediated by scandium trifluoromethanesulfonate completed the first total synthesis of (−)‐methylenebismehranine.
A Straightforward Approach towards Cyclic Photoactivatable Tubulysin Derivatives
Authors: Hoffmann Judith , Kazmaier Uli
Published: September 2014

The development of a new photolabile protecting group containing an additional allyl functionality allows the synthesis of cyclic photoactivatable natural products. Cyclization occurs between the allyl moiety in the protecting group and a second double bond in the target molecule by means of ring‐closing metathesis. Cyclization should increase the metabolic stability towards proteases. On the other hand, the conformational change should cause diminished biological activity. As illustrated for tubulysin derivatives, cyclic and photoactivatable drug candidates can easily be obtained in only two steps from simple building blocks through Ugi reaction and ring‐closing metathesis. The photolabile protecting group is introduced by means of the isocyanide component during the Ugi reaction.
Selective Formation of Metastable Ferrihydrite in the Chiton Tooth
Authors: Gordon Lyle M. , Román Jessica K. , Everly R. Michael , Cohen Michael J. , Wilker Jonathan J. , Joester Derk
Published: September 2014

Metastable precursors are thought to play a major role in the ability of organisms to create mineralized tissues. Of particular interest are the hard and abrasion‐resistant teeth formed by chitons, a class of rock‐grazing mollusks. The formation of chiton teeth relies on the precipitation of metastable ferrihydrite (Fh) in an organic scaffold as a precursor to magnetite. In vitro synthesis of Fh under physiological conditions has been challenging. Using a combination of X‐ray absorption and electron paramagnetic resonance spectroscopy, we show that, prior to Fh formation in the chiton tooth, iron ions are complexed by the organic matrix. In vitro experiments demonstrate that such complexes facilitate the formation of Fh under physiological conditions. These results indicate that acidic molecules may be integral to controlling Fh formation in the chiton tooth. This biological approach to polymorph selection is not limited to specialized proteins and can be expropriated using simple chemistry.
Improving energy efficiency of distillation using heat pump assisted columns
Authors: Reddy C. C. S. , Fang Y. , Rangaiah G. P.
Published: September 2014

Distillation is a widely used separation technique in process industries, although it requires substantial energy inputs. In this study on improving the energy efficiency, both compression and absorption type heat pumps along with feed preheat are analyzed for two common distillation processes of a typical petroleum refinery, to recover waste heat at lower temperatures by upgrading it to useful temperature levels. The heat pumps are also coupled with intermediate heat exchangers (HEXs) to improve cost savings further. The case studies in this investigation are sour water stripper and the C4 separation unit consisting of a deisobutanizer and debutanizer; these include distillation with a partial condenser and separation of compounds having wide boiling points, which have not been studied earlier. Results from these case studies indicate that heat pumps can generally achieve attractive cost savings and that further addition of intermediate HEXs usually worsens the payback, mainly due to additional capital cost. However, intermediate HEXs are beneficial for cases where heat pump application between condenser and reboiler is not economical or feasible, especially in the case of distillation operations requiring very high temperature lifts. © 2014 Curtin University of Technology and John Wiley & Sons, Ltd.
Phosphorus adsorption onto an industrial acidified laterite by‐product: equilibrium and thermodynamic investigation
Authors: Glocheux Yoann , Méndez Pasarín Martin , Albadarin Ahmad B. , Mangwandi Chirangano , Chazarenc Florent , Walker Gavin M.
Published: September 2014

The present research investigates the uptake of phosphate ions from aqueous solutions using acidified laterite (ALS), a by‐product from the production of ferric aluminium sulfate using laterite. Phosphate adsorption experiments were performed in batch systems to determine the amount of phosphate adsorbed as a function of solution pH, adsorbent dosage and thermodynamic parameters per fixed P concentration. Kinetic studies were also carried out to study the effect of adsorbent particle sizes. The maximum removal capacity of ALS observed at pH 5 was 3.68 mg P g−1. It was found that as the adsorbent dosage increases, the equilibrium pH decreases, so an adsorbent dosage of 1.0 g L−1 of ALS was selected. Adsorption capacity (qm) calculated from the Langmuir isotherm was found to be 2.73 mg g−1. Kinetic experimental data were mathematically well described using the pseudo first‐order model over the full range of the adsorbent particle size. The adsorption reactions were endothermic, and the process of adsorption was favoured at high temperature; the ΔG and ΔH values implied that the main adsorption mechanism of P onto ALS is physisorption. The desorption studies indicated the need to consider a NaOH 0.1 M solution as an optimal solution for practical regeneration applications. © 2014 Curtin University of Technology and John Wiley & Sons, Ltd.
A study of the effect of injection pressure on the combustion, performance, and emission characteristics of cardanol biofuel blend fuelled compression ignition engine
Authors: Dinesha P. , Mohanan P.
Published: September 2014

The use of biodiesel along with other alternative fuel sources is expected to address the twin problems of pollution and energy security. This study investigates the effect of injection pressure (IP) on the performance, combustion, and emission characteristics of a four‐stroke single cylinder direct injection diesel engine fuelled with a biofuel, namely cardanol‐methanol‐diesel blend (B20M10). The results are compared with baseline diesel operations under standard operating conditions. The biofuel blend B20M10 (20% cardanol, 10% methanol, and 70% diesel) is used as fuel, and the combustion, performance, and emission characteristics are investigated at IP levels of 180, 200, and 220 bar. The test results show that the optimum fuel IP is 220 bar with B20M10. At this optimized pressure, a reduction in CO, HC, and smoke emissions with an increase in the oxides of nitrogen (NOx) and brake thermal efficiency (BTE) are noticed compared with 180 and 200 bar B20M10 operations. When compared with diesel (180 bar IP), B20M10 blend at 220 bar IP gives marginally lower BTE and lower CO and HC emissions, but oxides of nitrogen and smoke are slightly more. © 2014 Curtin University of Technology and John Wiley & Sons, Ltd.
Effects of the film thickness on the morphology, structure, and crystal orientation behavior of poly(chloro‐p‐xylylene) films
Authors: Tan Kaiyuan , Zhang Hao , Wen Maoping , Du Ziwei
Published: September 2014

Poly(chloro‐p‐xylylene) (PPXC) films with a thickness range encompassing more than three orders of magnitude (from 102 nm to 102 μm) were prepared on Si substrates by the chemical vapor deposition method under the same conditions. The effect of the film thickness (d) on the morphology, crystal structure, and crystal orientation behavior of the PPXC films was studied. The average roughness of the root mean square (rms) of the films increased with increasing d according to a power law (rms ≈ dβ, where β is an exponent that depends on the film growth process over time and β = 0.240±0.005, as probed by atomic force microscopy), and the monomer diffusion and relaxation of polymer were suggested as the primary factors governing this morphological evolution. The X‐ray diffraction results indicate that both the crystallinity and crystal size of PPXC increased with increasing d due to the surface confinement effect between the film and the substrate, which retarded the crystallization process. The X‐ray pole figures suggested that the (020) fiber textures with the b axis parallel to the Si substrate normal existed in the PPXC films; these fiber textures, mainly composed of edge‐on crystal lamellae, were thermodynamically favored. The Herman's orientation factor of the fiber textures increased gradually as d grew; this indicated that stronger (020) fiber textures with higher concentrations of edge‐on lamellae existed in the thicker PPXC films. This thickness dependence of the crystal orientation behavior was interpreted to be caused by the strong adhesion between the polymer chains and the substrate. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 41394.
Multinuclear solid‐state NMR investigation of the moisture distribution in PEEK‐PBI and PEKK‐PBI blends
Authors: Pope Jacqueline C. , Sue Hung‐Jue , Bremner Tim , Blümel Janet
Published: September 2014

Blends of polyaryletherketones (PAEK), such as polyetheretherketones (PEEK) and polyetherketoneketones (PEKK), with polybenzimidazole (PBI) are of commercial interest due to their improved high‐temperature stability and wear properties. The changes of PBI and its PEEK‐ and PEKK‐blends (50 : 50 wt %) after immersing them in liquid H2O and D2O, and exposing them to D2O steam at elevated temperatures and pressures are investigated by multinuclear solid‐state NMR and IR spectroscopy. Macroscopic morphological and chemical changes on the molecular scale, which take place upon high‐temperature steam‐treatment and the extent and reversibility of moisture uptake have been investigated. Interactions and reactions of water, steam, and aqueous solutions of LiCl and ZnBr2 with the functional groups of the polymer components have been studied using D2O in combination with IR, 1H wideline, 2H, 7Li, and 79Br MAS, as well as 13C and 15N CP/MAS NMR spectroscopy. Different locations and types of water and protons in the blends have been described and PBI has been proven to be mainly responsible for water and salt uptake into the blends. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 41421.
DIVERSITY IN GUT MICROFLORA OF Helicoverpa armigera POPULATIONS FROM DIFFERENT REGIONS IN RELATION TO BIOLOGICAL ACTIVITY OF Bacillus thuringiensis δ‐ENDOTOXIN Cry1Ac
Authors: Paramasiva Inakarla , Shouche Yogesh , Kulkarni Girish Jayant , Krishnayya Pulipaka Venkata , Akbar Shaik Mohammed , Sharma Hari Chand
Published: September 2014

Transgenic crops expressing toxin proteins from Bacillus thuringiensis (Bt) have been deployed on a large scale for management of Helicoverpa armigera. Resistance to Bt toxins has been documented in several papers, and therefore, we examined the role of midgut microflora of H. armigera in its susceptibility to Bt toxins. The susceptibility of H. armigera to Bt toxin Cry1Ac was assessed using Log‐dose‐Probit analysis, and the microbial communities were identified by 16S rRNA sequencing. The H. armigera populations from nine locations harbored diverse microbial communities, and had some unique bacteria, suggesting a wide geographical variation in microbial community in the midgut of the pod borer larvae. Phylotypes belonging to 32 genera were identified in the H. armigera midgut in field populations from nine locations. Bacteria belonging to Enterobacteriaceae (Order Bacillales) were present in all the populations, and these may be the common members of the H. armigera larval midgut microflora. Presence and/or absence of certain species were linked to H. armigera susceptibility to Bt toxins, but there were no clear trends across locations. Variation in susceptibility of F1 neonates of H. armigera from different locations to the Bt toxin Cry1Ac was found to be 3.4‐fold. These findings support the idea that insect migut microflora may influence the biological activity of Bt toxins.
Studies on luminescence from a cerium‐doped strontium stannate phosphor
Authors: Karabulut Yüksel , Ayvacikli Mehmet , Canimoglu Adil , Garcia Guinea Javier , Can Nurdogan
Published: September 2014

The crystal structure and morphology of Ce3+‐doped SrSnO3 materials prepared using the solid‐state reaction method were extensively characterized using experimental techniques. X‐Ray diffraction results show that the cerium substitution of strontium does not change the structure of the strontium stannate. Raman spectroscopy was used to investigate the microstructures and lattice vibrations. Environmental scanning electron microscopy images showed that phosphors aggregate and their particles form irregular shapes. SrSnO3 exhibits an intense green emission with a broad band originating from the 5d1 → 4f1 transition of cerium. It was observed that, after exposure to beta‐irradiation, the glow curve of this material has two broad thermoluminescence peaks, one centered at ~ 127°C and the other at ~ 245°C for a heating rate of 5 K/s. The kinetic parameters, which include the frequency factor and the activation energy of the material, were calculated using Chen's method, after beta‐irradiation. The fading and reusability of the phosphor were also studied and it was found that the phosphor is suitable for radiation dosimetry. Copyright © 2014 John Wiley & Sons, Ltd.
Gender‐specific distribution of selenium to serum selenoproteins: Associations with total selenium levels, age, smoking, body mass index, and physical activity
Authors: Letsiou S. , Nomikos T. , Panagiotakos D.B. , Pergantis S.A. , Fragopoulou E. , Pitsavos C. , Stefanadis C. , Antonopoulou S.
Published: September 2014

The epidemiology of selenium (Se) is mainly based on the determination of total serum selenium levels (TSe) which by many aspects is an inadequate marker of Se status. In this study we applied a recently developed LC‐ICP‐MS method, for the determination of the selenium content of the three main serum selenium‐containing proteins, in a subcohort of the ATTICA study. This enables us to investigate whether the selenium distribution to selenoproteins may correlate with demographic (age, gender) and lifestyle variables (smoking, physical activity) that are crucial for the development of chronic diseases. A sub‐sample from the ATTICA Study, consisted of 236 males (40 ± 11 years) and 163 females (38 ± 12 years), was selected. The selenium content of glutathione peroxidase (GPx‐3), selenoprotein P (SelP) and selenoalbumin (SeAlb) was determined in serum by LC‐ICP/MS method. We found that 26% of TSe is found in GPx‐3, 61% in SelP and 13% in SeAlb. We have assessed the different ratios of selenoproteins' selenium content (Se‐GPX‐3/Se‐SelP, Se‐GPX‐3/Se‐SeAlb, Se‐SelP/Se‐SeAlb), showing that people with similar TSe may have different distribution of this selenium to selenoproteins. Total selenium levels and gender are the variables that mostly affect selenium distribution to selenoproteins while age, smoking, physical activity and BMI do not significantly influence selenium distribution. In conclusion, the simultaneous determination of the selenium content of serum selenium‐containing selenoproteins is necessary for a thorough estimation of selenium status. The ratio of the Se content between selenoproteins may be proven a novel, valid marker of selenium status. © 2014 BioFactors, 40(5):524–535, 2014
Significance of pharmaceutical excipients in prescribed medicines: a case report
Authors: Maharaj Sandeep , Pandey Sureshwar , Maharaj Keshwar , Sheik Meera Sharief , Dhingra Sameer
Published: September 2014

Key Clinical Message

Pharmaceutical excipients need careful observation as they play a significant role in treatment outcomes. It is imperative for a physician to collect complete patient profile before prescribing new medications for current treatment. We present a case report on the significance of pharmaceutical excipients in prescribed medicines.
Placenta percreta managed by transverse uterine fundal incision with retrograde cesarean hysterectomy: a novel surgical approach
Authors: Matsuzaki Shinya , Yoshino Kiyoshi , Kumasawa Keiichi , Satou Noriko , Mimura Kazuya , Kanagawa Takeshi , Ueda Yutaka , Kimura Tadashi
Published: September 2014

Key Clinical Message

Placenta percreta (with bladder invasion) is a rare obstetric condition with the risk of massive intraoperative hemorrhage. In these cases, the combination of a transverse uterine fundal incision and retrograde cesarean hysterectomy could be useful to minimize maternal hemorrhage and avoid severe bladder injury.
Oral infection control to assist infliximab therapy in a Behçet's disease patient with severe eye inflammation in response to dental treatment: a case report
Authors: Kudo Chieko , Wakabayashi Hiroshi , Shimoe Masayuki , Kobayashi Hiroya , Ito Takashi , Ohkawa Toshinori , Isoshima‐Nakamura Arisa , Mineshiba Junji , Yoshioka Norie , Nawachi Kumiko , Maeda Hiroshi , Matsuo Toshihiko , Makino Hirofumi , Takashiba Shogo
Published: September 2014

Key Clinical Message

We report a case of Behçet's disease which was aggravated by psychological stress and oral infection. The control of oral infection under medical and dental collaboration is important for providing Behçet's disease patients with the optimal medical care and for facilitating the relief of the primary disease.
Gingival overgrowth caused by vitamin C deficiency associated with metabolic syndrome and severe periodontal infection: a case report
Authors: Omori Kazuhiro , Hanayama Yoshihisa , Naruishi Koji , Akiyama Kentaro , Maeda Hiroshi , Otsuka Fumio , Takashiba Shogo
Published: September 2014

It has been suggested that vitamin C deficiency/scurvy is associated with gingival inflammatory changes; however, the disorder is very infrequently encountered in the modern era. Here, we report a case of extensive gingival overgrowth caused by vitamin C deficiency associated with metabolic syndrome and severe periodontal infection.
Induced negative pressure proposed as a new method for diagnosing hepatic hydrothorax involving minor leaks
Authors: Shimbo Asami , Matsuda Satoshi , Tejima Kazuaki , Yamahira Koh , Naka Kenichi , Arai Masahiro , Fujita Shuhei
Published: September 2014

Key Clinical Message

Hepatic hydrothorax is known as pleural effusion of hepatic origin, and is difficult to diagnose. We herein report the novel strategy combining radioisotope scintigraphy with chest drainage to definitively diagnose hepatic hydrothorax of an 85‐year‐old patient which would have been missed with conventional diagnostic methods.
A case of feverish neutropenia
Authors: Invernizzi Rosangela , Ambaglio Chiara , Quaglia Federica
Published: September 2014

Key Clinical Message

A case of feverish benign neutropenia occurring in a diabetic patient receiving pregabalin for peripheral neuropathy is reported. Although pregabalin‐induced neutropenia is very rare, it is important to keep in mind that this drug like other anticonvulsants used for neuropathic pain, can cause severe neutropenia.
A case of Barber‐Say syndrome in a male Japanese newborn
Authors: Suga Kenichi , Shono Miki , Goji Aya , Matsuura Sato , Inoue Miki , Kawahito Masami , Kinoshita Michiyo , Takeda Misa , Mori Kazuhiro
Published: September 2014

Key Clinical Message

We reported a case of Barber‐Say syndrome (BSS) in a Japanese newborn. Distinctive features of BSS were found; macrostomia, gingival dysplasia, cup‐shaped low‐set ears, wrinkling redundant skin, and hypertrichosis. Fundus showed subretinal drusenoid deposits, a novel finding of BSS. Genetic analysis is underway using next‐generation genome sequencing and microarray analysis.
First case of pulmonary tuberculosis and visceral leishmaniasis coinfection successfully treated with antituberculosis drug and liposomal amphotericin B
Authors: Hasnain Md. Golam , Ghosh Prakash , Sharafat Sonin Md. Shadab Ibn , Baker James , Mondal Dinesh
Published: September 2014

Key Clinical Message

Successful management of cases with visceral leishmaniasis (VL) and tuberculosis is a challenge for clinicians, because a guideline for that is currently unavailable. We report the first case in Bangladesh who developed VL during her treatment for pulmonary tuberculosis and was treated successfully with multidose liposomal amhptericin B for VL.
Base‐Free Non‐Noble‐Metal‐Catalyzed Hydrogen Generation from Formic Acid: Scope and Mechanistic Insights
Authors: Mellmann Dörthe , Barsch Enrico , Bauer Matthias , Grabow Kathleen , Boddien Albert , Kammer Anja , Sponholz Peter , Bentrup Ursula , Jackstell Ralf , Junge Henrik , Laurenczy Gábor , Ludwig Ralf , Beller Matthias
Published: September 2014

The iron‐catalyzed dehydrogenation of formic acid has been studied both experimentally and mechanistically. The most active catalysts were generated in situ from cationic FeII/FeIII precursors and tris[2‐(diphenylphosphino)ethyl]phosphine (1, PP3). In contrast to most known noble‐metal catalysts used for this transformation, no additional base was necessary. The activity of the iron catalyst depended highly on the solvent used, the presence of halide ions, the water content, and the ligand‐to‐metal ratio. The optimal catalytic performance was achieved by using [FeH(PP3)]BF4/PP3 in propylene carbonate in the presence of traces of water. With the exception of fluoride, the presence of halide ions in solution inhibited the catalytic activity. IR, Raman, UV/Vis, and EXAFS/XANES analyses gave detailed insights into the mechanism of hydrogen generation from formic acid at low temperature, supported by DFT calculations. In situ transmission FTIR measurements revealed the formation of an active iron formate species by the band observed at 1543 cm−1, which could be correlated with the evolution of gas. This active species was deactivated in the presence of chloride ions due to the formation of a chloro species (UV/Vis, Raman, IR, and XAS). In addition, XAS measurements demonstrated the importance of the solvent for the coordination of the PP3 ligand.
Synthesis and Properties of the Weakly Coordinating Anion [Me3NB12Cl11]−
Authors: Bolli Christoph , Derendorf Janis , Jenne Carsten , Scherer Harald , Sindlinger Christian P. , Wegener Bianca
Published: September 2014

The weakly coordinating anion [Me3NB12Cl11]− has been prepared by a simple two‐step procedure. The anion [Me3NB12Cl11]− is easily obtained in batches of up to 20 g by chlorination of the known [H3NB12H11]− anion with SbCl5 at about 190 °C and subsequent N‐methylation with methyl iodide. Starting from Na[Me3NB12Cl11], several synthetically useful salts with reactive cations ([NO]+, [Ph3C]+, and [(Et3Si)2H]+) were prepared. Full spectroscopic (NMR, IR, Raman, TGA, MS) characterization and single‐crystal X‐ray diffraction studies confirmed the identity and purity of the products. The thermal, chemical, and electrochemical stability as well as the basicity of the [Me3NB12Cl11]− anion is similar to that of the structurally related weakly coordinating 1‐carba‐closo‐dodecaborate and closo‐dodecaborate anions. The facile preparation of the [Me3NB12Cl11]− anion and its ideal chemical and physical properties make it a cheap alternative to other classes of weakly coordinating anions.
Activation of SO2 with [(η5‐C5Me5)2Ln(THF)2] (Ln=Eu, Yb) Leading to Dithionite and Sulfinate Complexes
Authors: Klementyeva Svetlana V. , Gamer Michael T. , Schmidt Anna‐Corina , Meyer Karsten , Konchenko Sergey N. , Roesky Peter W.
Published: September 2014

The reaction of decamethylytterbocene [(η5‐C5Me5)2Yb(THF)2] with SO2 at low temperature gave two new compounds, namely, the YbIII dithionite/sulfinate complex [{(η5‐C5Me5)2Yb(μ3,1κ2O1,3,2κ3O2,2′,4‐S2O4)}2{(η5‐C5Me5)Yb(μ,1κO,2κO′‐C5Me5SO2)}2] (1) and the YbIII dithionite complex [{(η5‐C5Me5)2Yb}2(μ,1κ2O1,3,2κ2O2,4‐S2O4)] (2). After extraction of 1, the mixture was heated to give the dinuclear tetrasulfinate complex [{(η5‐C5Me5)Yb}2(μ,κO,κO’‐C5Me5SO2)4] (3 a). In contrast, from the reaction of [(η5‐C5Me5)2Eu(THF)2] with SO2 only the tetrasulfinate complex [{(η5‐C5Me5)Eu}2(μ,κO,κO’‐C5Me5SO2)4] (3 b) was isolated. Two major reaction pathways were observed: 1) reductive coupling of two SO2 molecules to form the dithionite anion S2O42−; and 2) nucleophilic attack of one metallocene C5Me5 ligand on the sulfur atom of SO2. The compounds presented are the first dithionite and sulfinate complexes of the f‐elements.
ChemInform Abstract: Bonding in the Extended Metal Chain Compound La4Cl5C2.
Authors: Kang Dae‐Bok
Published: September 2014

Molecular orbital energy levels, density of states, and crystal orbital overlap population curves of the title compound are analyzed by means of extended Hueckel tight‐binding computations.
ChemInform Abstract: Dimethylammonium Tetraaqua(hydrogensulfato)sulfatocuprate(II).
Authors: Held Peter
Published: September 2014

[Me2NH2] [Cu(HSO4)(SO4)(H2O)4] crystallizes from an aqueous solution of CuSO4, Me2NH, and H2SO4 in a stoichiometric ratio at 25 °C.
ChemInform Abstract: α‐NH4Fe(HAsO4)2.
Authors: Ouerfelli Najoua , Souilem Amira , Zid Mohamed Faouzi , Driss Ahmed
Published: September 2014

The title compound is prepared by hydrothermal processing of an aqueous solution of NaBO3, (NH4)3(C2O4)3, and As2O5 (pH 1, autoclave, 453 K, 21 d).
ChemInform Abstract: Tetraamminepalladium(II) Dichloride Ammonia Tetrasolvate.
Authors: Grassl Tobias , Korber Nikolaus
Published: September 2014

Single crystals of [Pd(NH3)4]Cl2·4NH3 are grown from a mixture of Pd(en)Cl2 and D‐(+)‐glucono‐1,5‐lactone in liquid NH3 (1.
ChemInform Abstract: Mediator Enhanced Water Oxidation Using Rb4[RuII(bipy)3]5 [{RuIII4O4(OH)2 (H2O)4} (γ‐SiW10O36)2] Film Modified Electrodes.
Authors: Guo Si‐Xuan , Lee Chong‐Yong , Zhang Jie , Bond Alan M. , Geletii Yurii V. , Hill Craig L.
Published: September 2014

The H2O insoluble complex of title ([RuIIbipy]5[RuIII4POM]) is prepared by reduction of Rb8K2 [{RuIV4O4(OH)2 (H2O)4} (γ‐SiW10O36)2] with NaBH4 followed by precipitation with [Ru(bipy)3]Cl2.
ChemInform Abstract: High‐Pressure Synthesis and Structural Characterization of the Type II Clathrate Compound Na30.5Si136 Encapsulating Two Sodium Atoms in the Same Silicon Polyhedral Cages.
Authors: Yamanaka Shoji , Komatsu Masaya , Tanaka Masashi , Sawa Hiroshi , Inumaru Kei
Published: September 2014

Single crystals of clathrate compounds Na8Si46 (type I) and Na30.5Si136 (type II) are prepared from mixtures of NaSi and Si in a molar ratio of 1:4 under 5 GPa at 1000 and 800 °C, respectively.
ChemInform Abstract: Magnetocaloric Effect and Slow Magnetic Relaxation in Two Dense (3,12)‐Connected Lanthanide Complexes.
Authors: Han Song‐De , Miao Xiao‐Hong , Liu Sui‐Jun , Bu Xian‐He
Published: September 2014

Two (3,12)‐connected complexes with distorted cubic [Ln4O4] building units are synthesized.
ChemInform Abstract: Synergistic Combination of Multi‐ZrIV Cations and Lacunary Keggin Germanotungstates Leading to a Gigantic Zr24‐Cluster‐Substituted Polyoxometalate.
Authors: Huang Ling , Wang Sa‐Sa , Zhao Jun‐Wei , Cheng Lin , Yang Guo‐Yu
Published: September 2014

Colorless Na10K22 [Zr24O22(OH)10(H2O)2 (W2O10H)2 (GeW9O34)4(GeW8 O31)2]·85H2O crystals are hydrothermally synthesized from a mixture of ZrOCl2, K8Na2[A‐α‐GeW9O34], and Na2CO3 in a sodium acetate buffer (pH 4.8, autoclave, 200 °C, 3 d; 45% yield).
ChemInform Abstract: Enantioselective 1,4‐Addition of Kojic Acid Derivatives to β‐Nitroolefins Catalyzed by a Cinchonine Derived Sugar Thiourea.
Authors: Reddy B. V. Subba , Reddy S. Madhusudana , Swain Manisha , Dudem Srikanth , Kalivendi Shasi V. , Reddy C. Suresh
Published: September 2014

A novel bifunctional chinchona‐sugar based thiourea appears to be a highly efficient organocatalyst for the title reaction.
ChemInform Abstract: Asymmetric Construction of Substituted Pyrrolidines via 1,3‐Dipolar Cycloaddition of Azomethine Ylides and Chiral Acrylates Derived from Biomass.
Authors: Llompart David F. , Sarotti Ariel M. , Corne Valeria , Suarez Alejandra G. , Spanevello Rolando A. , Echeverria Gustavo A. , Piro Oscar E. , Castellano Eduardo E.
Published: September 2014

The first application of levoglucosenone‐derived chiral auxiliaries in asymmetric 1,3‐dipolar cycloaddition reactions of azomethine ylides is given.
ChemInform Abstract: Synthesis of Methyl (E)‐2‐[(3S,4S)‐4‐Hydroxy‐3‐(pent‐3‐yloxy)pyrrolidin‐2‐ylidene] propanoate and Its Unusual Recyclization.
Authors: Gimalova F. A. , Khalikova G. M. , Egorov V. A. , Mustafin A. G. , Miftakhov M. S.
Published: September 2014

Some reactions related to the synthesis of Tamiflu are reported.
ChemInform Abstract: Selective and Efficient Oxidation of Benzylic Alcohols to Benzaldehydes and Methyl Benzoates by Dibromo‐5,5‐dimethylhydantoin
Authors: Li Zhongzhou , Zhu Wei , Bao Jinlong , Zou Xinzhuo
Published: September 2014

without any catalyst
ChemInform Abstract: Silica‐Coated Magnetite Nanoparticles Stabilized Simple Mn‐Tetraphenylporphyrin for Aqueous Phase Catalytic Oxidations with tert‐Butyl Hydroperoxide.
Authors: Rezaeifard Abdolreza , Farshid Parisa , Jafarpour Maasoumeh , Moghaddam Gholamreza Kardan
Published: September 2014

A robust, magnetically recoverable, biomimetic nanocatalyst is designed for the oxidation of olefins, saturated hydrocarbons, alcohols and sulfides in aqueous solution.
ChemInform Abstract: Copper(II)‐Catalyzed Silylation of Activated Alkynes in Water: Diastereodivergent Access to E‐ or Z‐β‐Silyl‐α,β‐Unsaturated Carbonyl and Carboxyl Compounds.
Authors: Calderone Joseph A. , Santos Webster L.
Published: September 2014

An operationally simple and mild protocol is developed for the hydrosilylation of α,β‐alkynyl carbonyl compounds.
ChemInform Abstract: Iron‐Catalyzed C(sp3)—H Functionalization of Methyl Azaarenes with α‐Oxoesters: A Facile Approach to Lactic Acid Derivatives.
Authors: Jiang Kun , Pi Danwei , Zhou Haifeng , Liu Sensheng , Zou Kun
Published: September 2014

Fe(OAc)2 was used as catalyst for the reaction of ethyl glyoxylate or pyruvates with 2‐methylquinolines, 2‐methylpyridines, 2‐methylquinoxaline and 1‐methylisoquinoline to achieve the corresponding azaarene‐derived lactic acid derivatives.
ChemInform Abstract: Regioselective Preparation of Functional Aryl Ethers and Esters by Stepwise Nucleophilic Aromatic Substitution Reaction.
Authors: Krishnan Ranganathan , Parthiban Anbanandam
Published: September 2014

A wide variety of fluorinated aryl ethers and esters is prepared by nucleophilic aromatic substitution reaction of fluorinated benzonitriles with phenols or benzoic acid whereas, etherification can be performed stepwise or in an one‐step procedure.
ChemInform Abstract: A Simple and Efficient Approach to the Synthesis of β‐N‐Methylamino‐L‐alanine (BMAA).
Authors: Arevalo‐Garcia Enzo B. , Colmenares Q. Juan Carlos
Published: September 2014

Serine benzyl ester (I) is transformed into the title compound (IV) using a convenient two‐step protocol.
ChemInform Abstract: Domino 1,3‐Dipolar Cycloadditions of N‐Alkyl‐α‐Amino Esters with Paraformaldehyde: A Direct Access to α‐Hydroxymethyl α‐Amino Acids.
Authors: Castello Luis M. , Najera Carmen , Sansano Jose M.
Published: September 2014

The reaction of the aminoesters with paraformaldehyde can proceed under conventional heating or microwave‐assisted conditions.
ChemInform Abstract: Preparation of a Microsized Cerium Chloride‐Based Catalyst and Its Application in the Michael Addition of β‐Diketones to Vinyl Ketones.
Authors: Terent'ev Alexander O. , Vil' Vera A. , Yaremenko Ivan A. , Bityukov Oleg V. , Levitsky Dmitri O. , Chernyshev Vladimir V. , Nikishin Gennady I. , Fleury Fabrice
Published: September 2014

The title catalyst is prepared by heating the commercially available CeCl3·(H2O)7.
ChemInform Abstract: Synthesis of on Resin Poly(propylene Imine) Dendrimer and Its Use as Organocatalyst.
Authors: Gopalakrishna Panicker Rajesh Krishnan , Krishnapillai Sreekumar
Published: September 2014

A polystyrene supported dendrimeric amine catalyst is successfully applied to Knoevenagel condensations of aromatic aldehydes with malononitrile and ethyl cyanoacetate.
ChemInform Abstract: Synthesis of Aliphatic and α‐Halogenated Ketone Cyanohydrins with the Hydroxynitrile Lyase from Manihot esculenta.
Authors: Diebler Johannes , von Langermann Jan , Mell Annett , Hein Martin , Langer Peter , Kragl Udo
Published: September 2014

The reaction systems require careful adjustment since changes of e.g. the pH‐value and reaction time lead to a significant decrease of the conversions and enantioselectivities.
ChemInform Abstract: Chemoselective One‐Pot Synthesis of β‐Keto Sulfones from Ketones.
Authors: Rawat Vikas S. , Reddy Perla L. M. , Sreedhar Bojja
Published: September 2014

Nucleophilic addition of base generated enolates to in situ prepared sulfonyl iodides provides β‐keto sulfones.
ChemInform Abstract: A Molybdenum Based Metallomicellar Catalyst for Controlled and Selective Sulfoxidation Reactions in Aqueous Medium.
Authors: Chakravarthy Rajan Deepan , Ramkumar Venkatachalam , Chand Dillip Kumar
Published: September 2014

The applied catalytic system can be recycled at least four times and reused without significant loss of activity.
ChemInform Abstract: A General Suzuki Cross‐Coupling Reaction of Heteroaromatics Catalyzed by Nanopalladium on Amino‐Functionalized Siliceous Mesocellular Foam.
Authors: Bratt Emma , Verho Oscar , Johansson Magnus J. , Baeckvall Jan‐Erling
Published: September 2014

Nanopalladium on the title foam is found to be an efficient catalyst in Suzuki reaction.
ChemInform Abstract: Ultrasound Promoted One Pot Synthesis of Novel Fluorescent Triazolyl Spirocyclic Oxindoles Using DBU Based Task Specific Ionic Liquids and Their Antimicrobial Activity.
Authors: Singh Harjinder , Sindhu Jayant , Khurana Jitender M. , Sharma Chetan , Aneja K. R.
Published: September 2014

All new compounds (V), (VII), and (IX) show good antimicrobial activities and strong fluorescence in methanol with large stoke shift.
ChemInform Abstract: Convenient Synthesis of Enantiopure (R‐) and (S‐)‐3‐Fluoro‐3‐aminomethylpyrrolidines
Authors: Yarmolchuk Vladimir S. , Mykhalchuk Vladimir L. , Mykhailiuk Pavel K.
Published: September 2014

using α‐phenylethylamine as chiral auxiliary
ChemInform Abstract: New Synthesis of Unsymmetrically‐Substituted 2,5‐Diarylpyrroles from Homopropargyl Sulfonamides.
Authors: Van Rossom Wim , Matsushita Yoshitaka , Ariga Katsuhiko , Hill Jonathan P.
Published: September 2014

A novel approach to unsymmetrically 2,5‐diarylpyrroles by 5‐endo‐dig cyclization and simultaneous N‐detosylation is described.
ChemInform Abstract: Highly Diastereoselective and Regioselective Copper‐Catalyzed Nitrosoformate Dearomatization Reaction under Aerobic‐Oxidation Conditions.
Authors: Yang Weibo , Huang Long , Yu Yang , Pflaesterer Daniel , Rominger Frank , Hashmi A. Stephen K.
Published: September 2014

This is the first O‐selective nitrosoformate dearomatization under aerobic conditions.
ChemInform Abstract: Synthesis of 3‐Trifluoromethylpyrazoles via Trifluoromethylation/Cyclization of α,β‐Alkynic Hydrazones Using a Hypervalent Iodine Reagent.
Authors: Ji Guojing , Wang Xi , Zhang Songnan , Xu Yan , Ye Yuxuan , Li Ming , Zhang Yan , Wang Jianbo
Published: September 2014

A mild synthesis of trifluoromethyl‐substituted pyrazoles from propargyl hydrazones in the absence of a transition metal catalyst is described.
ChemInform Abstract: Mild Method for the Synthesis of 1H‐Indazoles Through Oxime‐Phosphonium Ion Intermediate.
Authors: Paul Saurav , Panda Subhankar , Manna Debasis
Published: September 2014

An intermolecular reaction with the optimized conditions is also presented to yield the corresponding hydrazone derivative (VII).
ChemInform Abstract: Rhodium‐Catalyzed Synthesis of Unsymmetrical Di(aryl/heteroaryl)methanes Using Aryl/heteroarylmethyl Ketones via CO—C Bond Cleavage.
Authors: Li Guangzhe , Arisawa Mieko , Yamaguchi Masahiko
Published: September 2014

Unsymmetrical diarylmethanes are prepared in the absence of alkali metal bases in moderate to good yields.
ChemInform Abstract: Zebrafish Based Strategy for the Identification of a Potential Pharmacophore for Apoptosis: A Greener CuAAC Approach for Novel 1,2,3‐Triazoles Derived from Mefenamic Acid.
Authors: Babu P. Vijaya , Mukherjee Soumita , Gorja Dhilli Rao , Yellanki Swapna , Medisetti Raghavender , Kulkarni Pushkar , Mukkanti K. , Pal Manojit
Published: September 2014

A wide range of 1,2,3‐triazoles derived from benzylic azide (I) are synthesized and tested in a new zebrafish based assay for the identification of a new pharmacophore for apoptosis.
ChemInform Abstract: Enantioselective Preparation of δ‐Valerolactones with Horse Liver Alcohol Dehydrogenase.
Authors: Diaz‐Rodriguez Alba , Iglesias‐Fernandez Javier , Rovira Carme , Gotor‐Fernandez Vicente
Published: September 2014

The enantioselectivity of product (II) is influenced by the presence of a substituent as well as its position.
ChemInform Abstract: Synthesis, Characterization, and Antibacterial Activity of Novel Pyridones.
Authors: Gezegen Hayreddin , Ceylan Mustafa , Karaman Isa , Sahin Ertan
Published: September 2014

Novel pyridone derivatives (IV) and (V) are synthesized by cyclization of adducts of diethylmalonate to chalcone with ammonium acetate in two different solvent systems.
ChemInform Abstract: Palladium‐Catalyzed Synthesis of Polysubstituted Quinolines from 2‐Amino Aromatic Ketones and Alkynes.
Authors: Zhou Wang , Lei Jianhua
Published: September 2014

PdBr2‐catalyzed one‐pot method for the synthesis of quinolines from 2‐amino aromatic ketones and alkynes is firstly reported.
ChemInform Abstract: Palladium‐Catalyzed Synthesis of Quino[2,3‐a]carbazoles and Indolo[2,3‐a]carbazoles via Intramolecular ortho‐Arylation.
Authors: Viji Mayavan , Ghosh Suman Kr , Nagarajan Rajagopal
Published: September 2014

The presence of electron‐withdrawing groups on the chloroquinoline‐3‐carbaldehyde moiety provides inseparable mixtures of the corresponding products in low yields.
ChemInform Abstract: Palladium‐Catalyzed Direct Arylation of 5‐Halouracils and 5‐Halouracil Nucleosides with Arenes and Heteroarenes Promoted by TBAF.
Authors: Liang Yong , Gloudeman Jennifer , Wnuk Stanislaw F.
Published: September 2014

The presented method may be useful for the synthesis of fluorescent 5‐heteroaryl substituted nucleosides.
ChemInform Abstract: A Direct Access to Bioactive Fused N‐Heterocyclic Acetic Acid Derivatives.
Authors: Adepu Raju , Rajitha A. , Ahuja Dipali , Sharma Atul Kumar , Ramudu B. , Kapavarapu Ravikumar , Parsa Kishore V. L. , Pal Manojit
Published: September 2014

A rapid access to novel, fused N‐heterocyclic acetic acid derivatives via a ligand‐ and additive‐free Cu‐mediated domino reaction of amides (I) with nitriles (II) is developed.
ChemInform Abstract: Synthesis of Quinazolinones from Anthranilamides and Aldehydes via Metal‐Free Aerobic Oxidation in DMSO.
Authors: Kim Na Yeun , Cheon Cheol‐Hong
Published: September 2014

The operationally simple method renders possible the synthesis of a wide range of substituted quinazolinones.
ChemInform Abstract: Emergence of Pyrido Quinoxalines as New Family of Antimalarial Agents.
Authors: Chandra Shekhar A. , Shanthan Rao P. , Narsaiah B. , Allanki Aparna Devi , Sijwali Puran Singh
Published: September 2014

A series of pyridoquinoxaline derivatives (24 examples) are synthesized and evaluated for their antimalarial activities against chloroquine sensitive (3D7) and drug resistant (Dd2) strains of Plasmodium falciparum.
ChemInform Abstract: An Extended Scope Synthesis of an Artificial Safranine Cofactor.
Authors: Raju Gheevarghese , Singh Sunaina , Mutter Andrew C. , Everson Bernard H. , Cerda Jose F. , Koder Ronald L.
Published: September 2014

Electron‐poor 15N‐safranine analogues are prepared via Ullmann coupling.
ChemInform Abstract: Rhodium(II)‐Catalyzed Intramolecular Annulation of 1‐Sulfonyl‐1,2,3‐triazoles with Pyrrole and Indole Rings: Facile Synthesis of N‐Bridgehead Azepine Skeletons.
Authors: Yang Jin‐Ming , Zhu Cheng‐Zhi , Tang Xiang‐Ying , Shi Min
Published: September 2014

A wide range of substituted pharmaceutically and biologically relevant azepine products is constructed.