bluuebunny/crossref_metadata_2025 huggingface dataset:
Novel lβ‐Methylcarbapenems Having Cyclic Sulfonamide Moieties: Synthesis and Evaluation of in‐vitro Biological Activity – Part II
Authors: Kim Seong Jong , Cho Jung‐Hyuck , Oh Chang‐Hyun
Published: July 2009

The synthesis of a new series of 1β‐methylcarbapenems having cyclic sulfonamide moieties is described. Their in‐vitro antibacterial activities against both Gram‐positive and Gram‐negative bacteria were tested and the effect of a substituent on the pyrrolidine ring was investigated. One particular compound IIIe having a [1,2,5]thiadiazolidin 1,1‐dioxide moiety showed the most potent antibacterial activity.
3‐Imidazolyl‐Substituted Flavans as Potential Antifungal Agents: Synthesis, Stereochemical Properties, and Antifungal Activity
Authors: Emami Saeed , Foroumadi Alireza
Published: July 2009

A new series of 3‐imidazolyl‐substituted flavan derivatives being equipped with a N‐(phenethyl)‐azole scaffold as the common pharmacophore of azole antifungals, were synthesized. The stereochemical and conformational properties of compounds were also characterized by 1H‐NMR data. The results of the antifungal evaluation of trans‐3‐imidazolyl‐substituted flavan‐4‐ones and (Z)‐trans‐3‐imidazolyl‐substituted flavan‐4‐one oximes in comparison with the reference drug fluconazole indicated that most target compounds possessed significant in‐vitro antifungal activities against the tested fungi, comparable or superior to fluconazole.
Synthesis of (1R,2R)‐ and (1S,2R)‐1,2‐Epoxy‐3‐hydroxypropylphosphonates as Analogues of Fosfomycin
Authors: Wróblewski Andrzej E. , Szewczyk Eligia M. , Baôk‐Sypień Irena I.
Published: July 2009

Cyclohexylammonium (1R,2R)‐1,2‐epoxy‐3‐hydroxypropylphosphonate was conveniently synthesized from dibenzyl (1S,2R)‐2,3‐O‐cyclohexylidene‐1,2,3‐trihydroxypropylphosphonate by a reaction sequence including mesylation, hydrolysis of acetal, intramolecular Williamson reaction, and hydrogenation in the presence of cyclohexylamine. For dibenzyl (1S,2R)‐2,3‐O‐cyclohexylidene‐1,2,3‐trihydroxypropylphosphonates the same approach was not successful, since prior the epoxide‐ring closure tritylation of HO–C3 in dibenzyl (1R,2R)‐2,3‐dihydroxy‐1‐mesyloxypropylphosphonate was necessary and the hydrogenolysis of dibenzyl (1S,2R)‐1,2‐epoxy‐3‐trityloxypropylphosphonate yielded a complex reaction mixture.
6‐Substituted Indolo[1,2‐c]quinazolines as New Antimicrobial Agents
Authors: Rohini Rondla , Shanker Kanne , Reddy P. Muralidhar , Sekhar Vasam Chandra , Ravinder Vadde
Published: July 2009

A series of 2‐o‐arylidineaminophenylindoles and their cyclic derivatives (indolo[1,2‐c]quinazolines) were synthesized. The reactions occurred under relatively mild conditions and afforded the desired product in good yields. Molecular structures of the synthesized compounds were confirmed by IR, 1H‐NMR, 13C‐NMR, MS spectra, and elemental analyses. Furthermore, all the final products were screened for in‐vitro antibacterial activity against three Gram‐positive and three Gram‐negative bacteria and also tested for their inhibitory action against three strains of fungi. Compound IIc showed potent activity against all the bacterial (except S. typhimurium) and fungal strains. Especially, compounds IIi and IIj which have isoquinolyl and pyridyl substituents displayed potent antibacterial as well as antifungal activities compared to those of the respective standard drugs Ampicillin and Ketoconazole.
Exposure to high static or pulsed magnetic fields does not affect cellular processes in the yeast Saccharomyces cerevisiae
Authors: Anton‐Leberre Veronique , Haanappel Evert , Marsaud Nathalie , Trouilh Lidwine , Benbadis Laurent , Boucherie Helian , Massou Sophie , François Jean M.
Published: July 2009

We report results of a study of the effects of strong static (up to 16 T for 8 h) and pulsed (up to 55 T single‐shot and 4 × 20 T repeated shots) magnetic fields on Saccharomyces cerevisiae cultures in the exponential phase of growth. In contrast to previous reports restricted to only a limited number of cellular parameters, we have examined a wide variety of cellular processes: genome‐scale gene expression, proteome profile, cell viability, morphology, and growth, metabolic and fermentation activity after magnetic field exposure. None of these cellular activities were impaired in response to static or pulsed magnetic field exposure. Our results confirm and extend previous reports on the absence of magnetic field effects on yeast and support the hypothesis that magnetic fields have no impact on the transcriptional machinery and on the integrity of unicellular biological systems. Bioelectromagnetics 31:28–38, 2010. © 2009 Wiley‐Liss, Inc.
Spectroscopic and molecular modeling studies on the binding of the flavonoid luteolin and human serum albumin
Authors: Jurasekova Zuzana , Marconi Giancarlo , Sanchez‐Cortes Santiago , Torreggiani Armida
Published: July 2009

Luteolin (LUT) is a polyphenolic compound, found in a variety of fruits, vegetables, and seeds, which has a variety of pharmacological properties. In the present contribution, binding of LUT to human serum albumin (HSA), the most abundant carrier protein in the blood, was investigated with the aim of describing the binding mode and parameters of the interaction. The application of circular dichroism, UV‐Vis absorption, fluorescence, Raman and surface‐enhanced Raman scattering spectroscopy combined with molecular modeling afforded a clear picture of the association mode of LUT to HSA. Specific interactions with protein amino acids were evidenced. LUT was found to be associated in subdomain IIA where an interaction with Trp‐214 is established. Hydrophobic and electrostatic interactions are the major acting forces in the binding of LUT to HSA. The HSA conformations were slightly altered by the drug complexation with reduction of α‐helix and increase of β‐turns structures, suggesting a partial protein unfolding. Also the configuration of at least two disulfide bridges were altered. Furthermore, the study of molecular modeling afforded the binding geometry. © 2009 Wiley Periodicals, Inc. Biopolymers 91: 917–927, 2009.

This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com
Refinement of the long‐range order parameter in predicting folding rates of two‐state proteins
Authors: Harihar B. , Selvaraj S.
Published: July 2009

Long‐range order (LRO) is one of the most successful descriptors in relating the three‐dimensional structures of proteins with their folding rates. LRO highlights the importance of long‐range contacts (residues that are far in sequence and closer in the 3D structure) in determining the folding rates of proteins across all structural classes of proteins. In this work, we have updated the data set of two‐state folding proteins to examine the robustness of LRO parameter and to assess whether any refinements are required in defining the computation of LRO. LRO shows a better correlation (r = −0.85) for the increased dataset with a very small difference in distance cut‐off compared to the old data set and reinforces the robustness of the parameter. When the dataset was grouped into three major structural classes, slight refinement of the parameter (distance of separation in space and sequence) gave better correlations. The corresponding correlation for the three structural classes are r = −0.92; sequence separation 23; spatial distance cut‐off 5.5 Å for all alpha structural class, r = −0.84; sequence separation 43; spatial distance cut‐off 7 Å for all beta structural class and r = −0.82; sequence separation 8; spatial distance cut‐off 8 Å for mixed class proteins. It is envisaged that during the process of protein folding, formation of long‐range contacts beyond the above sequence separation limits may play a key role in determining the folding rates of proteins, and this aspect is discussed in the light of experimental studies on the formation of interresidue contacts and end‐to‐end loops in unfolded polypeptide chains. © 2009 Wiley Periodicals, Inc. Biopolymers 91: 928–935, 2009.

This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com
Sequence‐dependent folding and unfolding of ligand‐bound purine riboswitches
Authors: Prychyna Oksana , Dahabieh Michael S. , Chao Jay , O'Neill Melanie A.
Published: July 2009

Riboswitch regulation of gene expression requires ligand‐mediated RNA folding. From the fluorescence lifetime distribution of bound 2‐aminopurine ligand, we resolve three RNA conformers (Co, Ci, Cc) of the liganded G‐ and A‐sensing riboswitches from Bacillus subtilis. The ligand binding affinities, and sensitivity to Mg2+, together with results from mutagenesis, suggest that Co and Ci are partially unfolded species compromised in key loop‐loop interactions present in the fully folded Cc. These data verify that the ligand‐bound riboswitches may dynamically fold and unfold in solution, and reveal differences in the distribution of folded states between two structurally homologous purine riboswitches: Ligand‐mediated folding of the G‐sensing riboswitch is more effective, less dependent on Mg2+, and less debilitated by mutation, than the A‐sensing riboswitch, which remains more unfolded in its liganded state. We propose that these sequence‐dependent RNA dynamics, which adjust the balance of ligand‐mediated folding and unfolding, enable different degrees of kinetic discrimination in ligand binding, and fine‐tuning of gene regulatory mechanisms. © 2009 Wiley Periodicals, Inc. Biopolymers 91: 953–965, 2009.

This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com
Transmural flow bioreactor for vascular tissue engineering
Authors: Bjork Jason W. , Tranquillo Robert T.
Published: July 2009

Nutrient transport limitation remains a fundamental issue for in vitro culture of engineered tissues. In this study, perfusion bioreactor configurations were investigated to provide uniform delivery of oxygen to media equivalents (MEs) being developed as the basis for tissue‐engineered arteries. Bioreactor configurations were developed to evaluate oxygen delivery associated with complete transmural flow (through the wall of the ME), complete axial flow (through the lumen), and a combination of these flows. In addition, transport models of the different flow configurations were analyzed to determine the most uniform oxygen profile throughout the tissue, incorporating direct measurements of tissue hydraulic conductivity, cellular O2 consumption kinetics, and cell density along with ME physical dimensions. Model results indicate that dissolved oxygen (DO) uniformity is improved when a combination of transmural and axial flow is implemented; however, detrimental effects could occur due to lumenal pressure exceeding the burst pressure or damaging interstitial shear stress imparted by excessive transmural flow rates or decreasing hydraulic conductivity due to ME compaction. The model was verified by comparing predicted with measured outlet DO concentrations. Based on these results, the combination of a controlled transmural flow coupled with axial flow presents an attractive means to increase the transport of nutrients to cells within the cultured tissue to improve growth (increased cell and extracellular matrix concentrations) as well as uniformity. Biotechnol. Bioeng. 2009; 104: 1197–1206. © 2009 Wiley Periodicals, Inc.
Controlled release of neurotrophin‐3 from fibrin‐based tissue engineering scaffolds enhances neural fiber sprouting following subacute spinal cord injury
Authors: Johnson Philip J. , Parker Stanley R. , Sakiyama‐Elbert Shelly E.
Published: July 2009

This study investigated whether delayed treatment of spinal cord injury with controlled release of neurotrophin‐3 (NT‐3) from fibrin scaffolds can stimulate enhanced neural fiber sprouting. Long Evans rats received a T9 dorsal hemisection spinal cord injury. Two weeks later, the injury site was re‐exposed, and either a fibrin scaffold alone, a fibrin scaffold containing a heparin‐based delivery system with different concentrations of NT‐3 (500 and 1,000 ng/mL), or a fibrin scaffold containing 1,000 ng/mL of NT‐3 (no delivery system) was implanted into the injury site. The injured spinal cords were evaluated for morphological differences using markers for neurons, astrocytes, and chondroitin sulfate proteoglycans 2 weeks after treatment. The addition of 500 ng/mL of NT‐3 with the delivery system resulted in an increase in neural fiber density compared to fibrin alone. These results demonstrate that the controlled release of NT‐3 from fibrin scaffolds can enhance neural fiber sprouting even when treatment is delayed 2 weeks following injury. Biotechnol. Bioeng. 2009; 104: 1207–1214. © 2009 Wiley Periodicals, Inc.
Ion‐Pair Binding: Is Binding Both Binding Better?
Authors: Roelens Stefano , Vacca Alberto , Francesconi Oscar , Venturi Chiara
Published: July 2009

It is often tempting to explain chemical phenomena on the basis of intuitive principles, but this practice can frequently lead to biased analysis of data and incorrect conclusions. One such intuitive principle is brought into play in the binding of salts by synthetic receptors. Following the heuristic concept that “binding both is binding better”, it is widely believed that ditopic receptors capable of binding both ionic partners of a salt are more effective than monotopic receptors because of a cooperative effect. Using a newly designed ditopic receptor and a generalized binding descriptor, we show here that, when the problem is correctly formulated and the appropriate algorithm is derived, the cooperativity principle is neither general nor predictable, and that competition between ion binding and ion pairing may even lead to inhibition rather than enhancement of the binding of an ion to a ditopic receptor.
Photoinduced Formation and Characterization of Electron–Hole Pairs in Azaxanthylium‐Derivatized Short Single‐Walled Carbon Nanotubes
Authors: Martín Roberto , Jiménez Liliana B. , Álvaro Mercedes , Scaiano J. C. , García Hermenegildo
Published: July 2009

2‐Azaxanthone, a nitrogenated derivative of the well‐studied organic chromophore xanthone, has been covalently bound through 2‐(ethylthio)ethylamido linkers to the carboxylic acid groups of short, soluble single‐walled carbon nanotubes (CNTs) of 450 nm average length, and the resulting azaxanthylium‐functionalized CNTs (AZX‐CNT, 8.5 wt % AZX content) characterized by solution 1H NMR, Raman and IR spectroscopy and thermogravimetric analysis. Comparison of the quenching of the triplet excited state of AZX (steady‐state and time‐resolved) and of the transient optical spectra of CNTs and AZX‐CNT shows that the covalent linkage boosts the interaction between the azaxanthylium moiety and the short CNT units. The triplet excited state of the azaxanthylium derivative is quenched by CNT with and without covalent bonding, but when it is covalently bonded, the singular transient spectrum is compatible with the photogeneration of electron holes through electron transfer from CNT to excited azaxanthylium units.
Systematic Investigation of Molecular Arrangements and Solid‐State Fluorescence Properties on Salts of Anthracene‐2,6‐disulfonic Acid with Aliphatic Primary Amines
Authors: Mizobe Yuji , Hinoue Tomoaki , Yamamoto Atsushi , Hisaki Ichiro , Miyata Mikiji , Hasegawa Yasuchika , Tohnai Norimitsu
Published: July 2009

Organic salts of anthracene‐2,6‐disulfonic acid (ADS) with a wide variety of primary amines have been fabricated, and their arrangements of anthracene molecules and solid‐state fluorescence properties investigated. Single‐crystal X‐ray studies reveal that the salts show seven types of crystal forms and corresponding molecular arrangements of anthracene moieties depending on the amine, while anthracene shows only one form and arrangement in the solid state. Depending on the molecular arrangements, the ADS salts exhibit various solid‐state fluorescence properties: spectral shift (30 nm) and suppression and enhancement of the fluorescence intensity. Especially the ADS salt with n‐heptylamine (nHepA), which shows discrete anthracene moieties in the crystal, exhibits the highest quantum yield (ΦF=46.1±0.2 %) in the series of ADS salts, which exceeds that of anthracene crystal (ΦF=42.9±0.2 %). From these systematic investigations on the arrangements and the solid‐state properties, the following factors are essential for high fluorescence quantum yield in the solid state: prevention of contact between π planes of anthracene moieties and immobilization of anthracene rings. In addition, such organic salts have potential as a system for modulating the molecular arrangements of fluorophores and the concomitant solid‐state properties. Thus, systematic investigation of this system constructs a library of arrangements and properties, and the library leads to remarkable strategies for the development of organic solid materials.
ChemInform Abstract: Crystal Structure of Thallium(I) Trithiocarbonate, Tl2CS3.
Authors: Beck Johannes , Benz Sebastian
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Structural and Magnetic Properties of Ba0.7Sr0.3Ru1‐xMnxO3 Hexagonal Perovskites.
Authors: Yin Congling , Li Guobao , Lin Jianhua , Attfield J. P.
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Experimental Study of the Ternary Ag—Cu—In Phase Diagram
Authors: Bahari Zahra , Elgadi Mohamed , Rivet Jacques , Dugue Jerome
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Green Procedure for the Synthesis of β‐Nitro Sulfides by Michael Addition of Thiols to Nitroolefins.
Authors: Hui Xin‐Pin , Yin Chao , Ma Jun , Xu Peng‐Fei
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Heterocycles from Aroylacetic Aldehydes and SH‐Containing Hydrazides.
Authors: Pakal'nis V. V. , Zerova I. V. , Yakimovich S. I. , Ershov A. Yu. , Lagoda I. V.
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Lewis Acid‐Promoted Electron Transfer Deoxygenation of Epoxides, Sulfoxides, and Amine N‐Oxides: The Role of Low‐Valent Niobium Complexes from NbCl5 and Zn.
Authors: Oh Kyungsoo , Knabe William Eric
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Practical, Two‐Step Synthesis of 2‐Substituted 1,3‐Butadienes.
Authors: Sen Sushmita , Singh Swapnil , Sieburth Scott McN.
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Asymmetric Synthesis of Chiral Roche Ester and Its Derivatives via Rh‐Catalyzed Enantioselective Hydrogenation with Chiral Phosphine‐Phosphoramidite Ligands.
Authors: Qiu Min , Wang Dao‐Yong , Hu Xiang‐Ping , Huang Jia‐Di , Yu Sai‐Bo , Deng Jun , Duan Zheng‐Chao , Zheng Zhuo
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Rhodium(I)‐Catalyzed Cycloisomerization of 1,3‐Dienes with Alkenes in a Tether.
Authors: Oonishi Yoshihiro , Saito Akira , Mori Miwako , Sato Yoshihiro
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: O‐Aryloxime Ethers from the Copper(II)‐Mediated Cross‐Coupling of Oximes and Phenylboronic Acids.
Authors: Ali Abdelselam , Meyer Adam G. , Tuck Kellie L.
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Poly(N,N′‐dichloro‐N‐ethylbenzene‐1,3‐disulfonamide) and N,N,N′,N′‐Tetrachlorobenzene‐1,3‐disulfonamide as Novel Reagents for the Synthesis of N‐Chloroamines, Nitriles and Aldehydes.
Authors: Ghorbani‐Vaghei Ramin , Veisi Hojat
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Propargylamines by a Copper‐Catalyzed Tandem anti‐Markovnikov Hydroamination and Alkyne Addition.
Authors: Zhou Lei , Bohle D. Scott , Jiang Huan‐Feng , Li Chao‐Jun
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Meta‐Selective Copper‐Catalyzed C—H Bond Arylation.
Authors: Phipps Robert J. , Gaunt Matthew J.
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Tetrasubstituted Furans via Sequential Pd(OAc)2/Zn(OTf)2‐Catalyzed Oxidation and Cyclization of Aromatic Alkynes with Molecular Oxygen.
Authors: Wang Azhong , Jiang Huanfeng , Xu Qiuxiang
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Diastereoselective Domino Heck—‐Suzuki Reaction: Synthesis of Substituted Methylenetetrahydrofurans.
Authors: Braun Manfred , Richrath Brigitte
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Novel Route to 2‐Trifluoromethylated Benzofurans.
Authors: Zhou Hua , Niu Jia‐Jia , Xu Jing‐Wei , Hu Shao‐Jing
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Regioselective Sonogashira Reactions of N‐Methyltetrabromopyrrole: First Synthesis of Tri‐ and Tetra(1‐alkynyl)pyrroles.
Authors: Ullah Farman , Dang Tung T. , Heinicke Joachim , Villinger Alexander , Langer Peter
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Approach to the Synthesis of 1H‐2‐Azaphenalene Derivatives.
Authors: Shklyaev Yu. V. , Feshin V. P. , Nifontov Yu. V.
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: An Efficient Biginelli One‐Pot Synthesis of New Benzoxazole‐Substituted Dihydropyrimidinones and Thiones Catalyzed by Alumina‐Supported Trifluoromethane Sulfonic Acid under Solvent‐Free Conditions.
Authors: Arjun M. , Sridhar D. , Chari M. Adharvana , Sarangapani M.
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of New Derivatives of 6‐(1‐Adamantylmethyl)‐4(3H)‐pyrimidinone
Authors: Novakov I. A. , Orlinson B. S. , Navrotskii M. B.
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Derivatives of Pyrazolo[1,5‐a]pyrimidines and Imidazo[1,5‐a]pyrimidines Proceeding from Alkyl 2‐Benzylidene‐3‐oxo‐3‐fluoroalkylpropionates.
Authors: Pryadeina M. V. , Burgart Ya. V. , Saloutin V. I. , Slepukhin P. A. , Sadchikova E. V. , Ulomskii E. N.
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Convenient Synthesis of Indolo‐ and Pyrrolobenzazepines via a Threefold Norbornene‐Mediated Domino Reaction.
Authors: Aureggi Valentina , Davoust Marion , Gericke Kersten M. , Lautens Mark
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Molecular Structure of Substituted 2‐Hydroxyperhydro[1,3,2]dioxaborinino[5,4‐c]pyridines, Perhydro[1,3]dioxano[5,4‐c]pyridine, and Their Precursor — 4‐Hydroxy‐3‐(α‐hydroxybenzyl)‐1‐methyl‐4‐phenylpiperidine.
Authors: Anh Le Tuan , Soldatenkov A. T. , Mamyrbekova Zh. A. , Soldatova S. A. , Polyanskiy K. B. , Tung Tran Thanh , Khrustalev V. N.
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A N,N′‐Dioxide—Copper(II) Complex as an Efficient Catalyst for the Enantioselective and Diastereoselective Mannich‐Type Reaction of Glycine Schiff Bases with Aldimines.
Authors: Shang Deju , Liu Yanling , Zhou Xin , Liu Xiaohua , Feng Xiaoming
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Stereoselective Transformation of Phytosphinosine to Safingol.
Authors: Kim Nari , Lee Sun Hee , Namgoong Sung Keon
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Solution‐Phase Synthesis of Well‐Defined Indium Sulfide Nanorods.
Authors: Franzman Matthew A. , Brutchey Richard L.
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Bright and Dark Excitons in Semiconductor Carbon Nanotubes: Insights from Electronic Structure Calculations
Authors: Kilina Svetlana , Badaeva Ekaterina , Piryatinski Andrei , Tretiak Sergei , Saxena Avadh , Bishop Alan R.
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Self‐Ordering Electrochemistry: A Review on Growth and Functionality of TiO2 Nanotubes and Other Self‐Aligned MOx Structures
Authors: Ghicov Andrei , Schmuki Patrik
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Zinc, Cadmium and Mercury
Authors: West Andrew J.
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Nickel, Palladium and Platinum
Authors: Fletcher Nicholas C.
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Ru(II) Catalysts Supported by Hydridotris(pyrazolyl)borate for the Hydroarylation of Olefins: Reaction Scope, Mechanistic Studies, and Guides for the Development of Improved Catalysts
Authors: Foley Nicholas A. , Lee John P. , Ke Zhuofeng , Gunnoe T. Brent , Cundari Thomas R.
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Creative Approaches Towards the Synthesis of 2,5‐Dihydrofurans, Thiophenes, and Pyrroles. One Method Does Not Fit All!
Authors: Brichacek Matthew , Njardarson Jon T.
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Chiral Recognition in Biomembrane Models: What is Behind a “Simple Model”
Authors: Borocci Stefano , Ceccacci Francesca , Cruciani Oscar , Mancini Giovanna , Sorrenti Alessandro
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Radicals by Design
Authors: Croft Anna K. , Lindsay Karl B. , Renaud Philippe , Skrydstrup Troels
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Ionic and Radical Fragmentations of Alkoxyhalocarbenes
Authors: Moss Robert A.
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Catalytic Carbonylations in Ionic Liquids
Authors: Consorti Crestina S. , Dupont Jairton
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Inverse Solid‐Phase Synthesis of Oligonucleotides
Authors: Morvan Francois , Vasseur Jean‐Jacques
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Catalytic Tandem Organic Sequences Through Selective Boron Addition Chemistry
Authors: Ramirez Jesus , Lillo Vanesa , Segarra Anna M. , Fernandez Elena
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Heat Conduction in Low‐dimensional Quantum Magnets
Authors: Hess Christian
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Modeling Kinetics of Subcellular Disposition of Chemicals
Authors: Balaz Stefan
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Conjugated Polyelectrolytes: Synthesis, Photophysics, and Applications
Authors: Jiang Hui , Taranekar Prasad , Reynolds John R. , Schanze Kirk S.
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Drugs of Abuse That Mediate Advanced Glycation End Product Formation: A Chemical Link to Disease Pathology
Authors: Treweek Jennifer B. , Dickerson Tobin J. , Janda Kim D.
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Adjunctive Low Molecular Weight Heparin During Fibrinolytic Therapy in Acute ST‐Segment Elevation Myocardial Infarction: A Meta‐Analysis Of Randomized Control Trials
Authors: Singh Sarabjeet , Bahekar Amol , Molnar Janos , Khosla Sandeep , Arora Rohit
Published: July 2009

Background

Recent data suggests that low molecular weight heparins (LMWHs) may be superior to unfractionated heparin (UFH) as an adjunct to fibrinolytic therapy in patients with acute ST‐segment elevation myocardial infarction (STEMI).

Hypothesis

We evaluated cardiac outcomes and the risk of major bleeding with LMWHs vs UFH in the management of STEMI.

Methods

Seven randomized trials of patients with acute STEMI treated with fibrinolytic therapy and adjunctive LMWHs through the index hospitalization or weight‐based UFH for at least 48 hours were identified. We analyzed both primary endpoints (death and nonfatal recurrent myocardial infarction through 30 days), and secondary endpoints (death, recurrent myocardial infarction, and major bleeding during index hospitalization at 7 days). Outcomes were computed using the Mantel‐Haenszel fixed‐effect model. A 2‐sided alpha error of < 0.05 was considered significant.

Results

Compared to UFH, LMWH significantly reduced reinfarction (p < 0.001) during hospitalization at 7 days and the effect remained consistent at 30 d (p < 0.001). When analyzed for mortality at 7 days and 30 days follow‐up, there were no statistically significant differences observed between the 2 groups. Additionally the LMWH group had higher risk of major bleeding (p < 0.001).

Conclusions

The present meta‐analysis suggests in patients receiving fibrinolytic therapy for STEMI, LMWHs as an adjunctive therapy is superior to UFH in reducing reinfarction during hospitalization at 7 days and at 30 days. The mortality was not significant between the 2 groups during hospitalization at 7 days and at 30 days. However, UFH is superior to LMWHs in the reduction of major bleeding at 7 days index hospitalization. Copyright © 2009 Wiley Periodicals, Inc.
Effect of slice angle on inhomogeneity artifact and its correction in slice‐selective MR imaging
Authors: Jung Kwan‐Jin , Moon Chan‐Hong
Published: July 2009

The inhomogeneity of a local magnetic field causes an image artifact of geometric distortion and intensity abnormality because of the slice offset and readout shift in slice‐selective MR imaging. It has been found that this artifact can be corrected by the projection of the slice offset onto the readout axis at a certain oblique slice angle. The slice angle for the artifact correction is determined by the amplitude of slice selection and readout gradients, and is independent of the magnetic field inhomogeneity and the main magnetic field direction. In addition, the existing view‐angle tilting technique is found to be valid only for the slice orientation orthogonal to the object axis. The slice angle effect on the inhomogeneity artifact was confirmed experimentally through phantom and volunteer's head imaging for both regular and view‐angle tilted spin echo sequences at 3 T. © 2009 Wiley Periodicals, Inc.Concepts Magn Reson Part A 34A: 238–248, 2009.
Loss‐of‐function analyses of the fragile X‐related and dopamine receptor genes by RNA interference in the cricket Gryllus bimaculatus
Authors: Hamada Aska , Miyawaki Katsuyuki , Honda‐Sumi Eri , Tomioka Kenji , Mito Taro , Ohuchi Hideyo , Noji Sumihare
Published: July 2009

In order to explore a possibility that the cricket Gryllus bimaculatus would be a useful model to unveil molecular mechanisms of human diseases, we performed loss‐of‐function analyses of Gryllus genes homologous to human genes that are responsible for human disorders, fragile X mental retardation 1 (fmr1) and Dopamine receptor (DopR). We cloned cDNAs of their Gryllus homologues, Gb'fmr1, Gb'DopRI, and Gb'DopRII, and analyzed their functions with use of nymphal RNA interference (RNAi). For Gb'fmr1, three major phenotypes were observed: (1) abnormal wing postures, (2) abnormal calling song, and (3) loss of the circadian locomotor rhythm, while for Gb'DopRI, defects of wing posture and morphology were found. These results indicate that the cricket has the potential to become a novel model system to explore human neuronal pathogenic mechanisms and to screen therapeutic drugs by RNAi. Developmental Dynamics 238:2025–2033, 2009. © 2009 Wiley‐Liss, Inc.
A Cre/LoxP conditional luciferase reporter transgenic mouse for bioluminescence monitoring of tumorigenesis
Authors: Woolfenden Steve , Zhu Haihao , Charest Al
Published: July 2009

Genetically engineered, Cre/LoxP‐conditional mouse models of cancer are designed to investigate the genetic contributors of tumorigenesis and are well suited to assess therapeutic treatment responses. The capacity to serially visualize tumor burden in a noninvasive fashion would greatly strengthen their applications. We report the generation of a bioluminescent reporter strain that allows monitoring of tumor development in preexisting conditional mouse tumor models. We demonstrate that, in a Cre‐dependent glioblastoma multiforme model, tumor initiation and progression is readily monitored over time and that luminescent output is related to tumor volume. Our results show that this reporter strain may be combined with various Cre/loxP mouse tumor models to allow for noninvasive longitudinal monitoring of tumor growth and therapeutic response in vivo. genesis 47:659–666, 2009. © 2009 Wiley‐Liss, Inc.
Mild Hydrothermal Synthesis and Structural Determination of Two Layered, Structurally Related Inorganic–Organic Hybrid Vanadates with Nickel(II) and Tris(2‐aminoethyl)amine
Authors: Larrea Edurne S. , Mesa José L. , Pizarro José L. , Rodríguez‐Fernández Jesús , Arriortua María I. , Rojo Teófilo
Published: July 2009

2D Ni2(C6H19N4)2(V6O18)·2H2O (1) and Ni2(C6H19N4)2(V6O18)·H2O (2) are inorganic–organic hybrid compounds that have been synthesised under hydrothermal conditions. Crystalline aggregates composed of both compounds were obtained and structural characterisation was subsequently carried out using single crystalline fragments of these aggregates. Optimisation of the synthetic conditions allowed us to obtain 1 as a polycrystalline powder. The crystal structures of 1 and 2 were solved using single‐crystal X‐ray diffraction data. Both compounds are structurally related, as the layers from which they are built have the same composition and connectivity in both structures. The main differences between them are the layer stacking and water contents. UV/Vis spectroscopy of 1 shows the characteristic features of the NiII d8 cation in slightly distorted octahedral symmetry. From the temperature‐dependent magnetic susceptibility measurements the parameter D/hc = –3.75 cm–1 was obtained. Phase 1 undergoes a reversible structural transformation at approximately 60 °C as a result of the dehydration process. This dehydration gives rise to a decrease in the unit cell volume.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Synthesis of SnO2, Fe2O3, and BiOCl Fibers from Inorganic Salts by a Templating Route
Authors: Yuan Rusheng , Lin Chen , Wu Baochao , Fu Xianzhi
Published: July 2009

SnO2, Fe2O3, and BiOCl fibers were synthesized from the corresponding chloride salts through a combination of templating and solvothermal processes. All the fibers possess distinct surface morphologies and lengths up to tens or hundreds of micrometers. Significantly, the BiOCl fibers with a novel heterogeneous structure were first prepared. The as‐prepared BiOCl fibers exhibit good photocatalytic activity for the degradation of methyl orange in aqueous medium under UV irradiation.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
An Unusual Anion–π Interaction in an ;rido Organometallic Assembly: Synthesis, First Crystal Structure, and Computational Study
Authors: Moussa Jamal , Gandon Vincent , Rager Marie Noelle , Malacria Max , Chamoreau Lise‐Marie , Amouri Hani
Published: July 2009

The organometallic assembly [Cp*Ir(η6‐C6H2O4)(BF2)2(CF3SO3)][Cp*Ir(μ‐Cl)3IrCp*] (3) was prepared from [Cp*Ir(solvent)3][OTf]2 (2) and 1,2,4,5 tetrahydroxybenzene (THB, 1) in acetone, in the presence of an excess amount of BF3·2H2O. Assembly 3 was fully characterized by multinuclear NMR spectroscopy. Remarkably, the X‐ray molecular structure of 3 shows that an anion–π interaction occurs between the neutral component Cp*Ir(η6‐C6H2O4)(BF2)2 of the assembly and the CF3SO3 anion of the cationic species [Cp*Ir(μ‐Cl)3IrCp*]. Computational analysis was carried out on 3 to unravel the nature of this noncovalent interaction. Such an example could serve as a model to explain the important role of anions in organometallic chemistry and asymmetric catalysis. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)