bluuebunny/crossref_metadata_2025 huggingface dataset:
Measurement, prevalence, causes, and health outcomes of co-existing multiple high-risk factors in pregnancy: a systematic review and meta-analysis
Authors: Zhang Yue , Wu Tingting , Ding Weijie , Wang Hui , Fawad Muhammad , Adane Akilew , Dai Xiaochen , Zhu Xiaoqin , Xu Xiaolin
Published: December 2022

Background
The co-occurrence of multiple high-risk factors during pregnancy (MHFP) is becoming increasingly common in transitioning populations, and may cause higher risk of adverse pregnancy outcomes. We performed a systematic review to better understand and summarize current evidence on MHFP.
Methods
Of 10,502 studies found, 46 original research met the inclusion criteria. Existing evidence on the measurement and definition, prevalence, causes, and health outcomes of MHFP were extracted and synthesized. The prevalence of MHFP was pooled through meta-analysis with random effects model. The linear regression model was used to estimate the trends of MHFP prevalence stratified by income levels of countries.
Results
Among 46 included studies, 76% were from high-income countries (HICs). The definition and types of high-risk factors in pregnancy are complex, multidimensional, and subjective. Four dimensions of MHFP were identified, including physical conditions, mental conditions, social-behavioural problems, and pregnancy history. Co-existing multiple physical conditions were the most common MHFP patterns, and anxiety-depression was the most studied MHFP pair. The overall pooled prevalence of MHFP was 16% according to included studies, with similar prevalence in HICs and low- and middle-income countries (LMICs). However, publications from LMICs were limited. Only three studies investigated the potential causes of MHFP. MHFP would affect women and their children’s health at multiple life stages.
Conclusion
The definition, measurement, potential clustered patterns, causes, and health outcomes of MHFP are poorly reported and highly variable. Relevant studies, including prospective cohort studies and randomized control trials, are warranted to provide more evidence on MHFP, so as better design and implement prevention and intervention programmes.
Transcriptome sequencing of ceRNA network constructing in status epilepticus mice treated by low-frequency repetitive transcranial magnetic stimulation
Authors: Zhang Shaotian , Zou Huihui , Zou Xiaopei , Ke Jiaqia , Zheng Bofang , Chen Xinrun , Zhou Xianju , Wei Jiana
Published: December 2022

It is shown that much advances were made in the treatment of repetitive transcranial magnetic stimulation (rTMS) for neurological and psychiatric diseases in recent years studies. This study aimed to reveal how rTMS exerts it therapeutic effects by regulating competitive endogenous RNAs (ceRNAs) of lncRNA-miRNA-mRNA. The distinction in lncRNA, miRNA and mRNA expression between low-frequency rTMS-treated male SE mice and male SE mice treated with sham rTMS were analyzed by high-throughput sequencing. The Gene Ontology (GO) functional enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were carried out. Gene-Gene Cross Linkage Network was established, and pivotal genes were screened out. qRT-PCR was used to verify gene-gene interactions. In short, there were 1615 lncRNAs, 510 mRNAs and 17 miRNAs differentially expressed between the low-frequency rTMS group and the sham rTMS group. The expression difference of these lncRNAs, mRNAs, and miRNAs by microarray detection were consistent with the resutls by qPCR. GO functional enrichment showed that immune-associated molecular mechanisms and biological processes, GABA-A receptor activity play a role in SE mice treated with low-frequency rTMS. As revealed by KEGG pathway enrichment analysis, differentially expressed genes are correlated to T cell receptor signaling pathway, primary immune deficiency and Th17 cell differentiation signaling pathway. Gene -gene cross linkage network was established on the basis of Pearson's correlation coefficient and miRNA. In conclusion, LF-rTMS alleviates SE through regulating the GABA-A receptor activity transmission, improving immune functions and biological processes, implicating that LF-rTMS may be a viable therapeutic option for epilepsy.
Comprehensive Statistics of Test Scores Based on the Thought of Relative Criterion
Authors: Liu Jingang
Published: December 2022

The comprehensive statistical ranking of exam score is extremely important for tens of millions of Chinese students taking the national college entrance examination every year. With the gradual improvement of people's understanding of the idea of relative criterion, it is found that the traditional statistical method uses the idea of subjective and absolute standard, and there is a large error between its statistical results and the objective reality. This error leads to great problems in talent selection, which should be abandoned. This paper puts forward that the examination results should be like a timing running competition, without the limit of the maximum full score. Under the guidance of the thought of relative criterion, the objective and scientific theory of relative criterion is adopted for the comprehensive statistics of examination results. In this paper, the application of the formula of relative criterion theory to the comprehensive statistics of examination results is expounded step by step from the simple to the profound in combination with the current actual situation; The specific calculation method is given in detail with an example. A simple relative criterion value of similar exchange rate is derived from the comprehensive statistics of ten million scale examinations. And the method of regional statistics based on relative criterion theory is used to solve the problem of disunity of test papers.
Acaricidal activity of Piper nigrum fruit extracts on the cattle tick, Rhipicephalus (Boophilus) australis (syn. R. microplus)
Authors: Toussirot Marine , Coulerie Paul , Hüe Thomas , Maciuk Alexandre , Kagy Valérie
Published: December 2022

Background
The cattle farming parasite Rhipicephalus (Boophilus) australis is the main tick and one of the most important in the world from an economic point of view. Various studies have been developed in order to find plant extracts with effective acaricidal properties and environmentally friendly. Studies involving plant extracts for parasite control on commercial animal herds is a developing area in New Caledonia. Bioactive natural products play an important role as lead compounds in the development of new pesticides.
Results
We screened 200 extracts obtained from 70 plant species against R. (B.) australis (Canestrini 1887 ; syn. R. (B.) microplus) (Acari, Ixodidae) larvae, the cattle tick, an haematophagous parasite The most active extracts were obtained from Piper nigrum L. and especially the ethanolic extract of dried fruits as well as the ethyl acetate extract and the methanolic extract of stems which all exhibited 100% larvicidal activity. Bio-guided fractionation of the ethanolic extract of dried mature fruits using the same assay led to the isolation of five compounds belonging to piperamide family. The structures of isolated compounds were elucidated using spectroscopic methods: ESI-HRMS, 1H- and 13C-NMR spectral data, including DEPT and 2D-NMR experiments (COSY, HSQC, HMBC, and NOESY). These include 1 compound described for the fisrt time in P. nigrum, homopellitorine (2) and 4 known compounds, namely pellitorine (1), pipyaqubine (3), 2-methylpropylamide (4) and N-isobutyl-2,4-eicosadienamide (5).
Conclusion
This first report on the larvicidal activity of P. nigrum extract and pure compounds on this tick species suggests that P. nigrum could be a natural biosourced alternative for the control of the larval stage of R. australis (syn. R. microplus).
Negative phototaxis of jumping cocooned parasitoid wasp larvae against short wavelengths and physicochemical properties of the cocoon shell
Authors: Iwase Shun-ichiro , Sugawara Yuma , Fukuda Katsuto , Tuda Midori
Published: December 2022

A parasitoid wasp, Bathyplectes anurus, is a successful biocontrol agent against the alfalfa weevil, a pest of beneficial fabaceous plants such as alfalfa and chinese milk vetch. One of the possible reasons for the success in hot climates may be the ability of the cocooned larvae of this wasp to repeatedly jump and roll until they relocate themselves away from detrimental sunlight and heat. It is not yet known which wavelengths of light trigger the larval avoidance behavior, and microstructure of the cocoon shell that should allow light transmission. Here, the response of the cocooned larvae to different wavelengths, and the microstructure, hardness and elemental components of the cocoon shell were studied. A population of cocooned larvae were introduced on the boundary line between illuminated and shaded areas with blue, green, red, or near-infrared light-emitting diodes. The cocoons moved away from the blue and green light. The distance from the boundary to the cocoons in the shaded area was longer under these long wavelengths, followed by the red light and shortest under the near-infrared light and nil under darkness. No difference was found in mortality between different wavelengths after three days of illumination. Scanning electron microscope observations of the surface of the cocoon shell revealed that the belt-like middle ridge was porous with fibers, which likely allows ventilation and light transmission. The ridge and main body showed similar elemental composition, except that the ridge contained higher proportions of sulfur and calcium and was 1.9 times harder than the main body.
Analytical methodology for novel film forming mafenide spray: Assay and Drug excipient compatibility study by HPLC-PDA
Authors: Mahajan Rupali , Chandragiri Saiteja , Gananadhamu Samanthula , Borse Vivek , Asthana Amit
Published: December 2022

This paper describes the short, precise, and accurate reverse-phase HPLC method for quantifying mafenide in the final product of a film-forming spray formulation. Further, the method is validated per the International Council for Harmonization (ICH) guidelines. The chromatographic separation of the formulation was achieved using mobile phase A as 10 mM potassium dihydrogen phosphate (KH2PO4) and mobile phase B as methanol (HPLC grade) in the ratio of 85:15 V/V. Several columns were screened, and finally, InertSustain C8 (4.6 x 250 mm), spherical 5µm particle size, was chosen for the final method. The chromatography was carried at ambient room temperature with a flow rate of 0.8 mL/min. For the detection of the analyte, 222 nm (λmax) was selected after scanning the sample in the PDA detector. The developed method was linear in the range of 5 ppm to 25 ppm of mafenide. The method proposed here has an excellent regression coefficient (R2) of 0.9995 with a precision of results less than 2% RSD. The percentage recovery values and assay readings of 98–102% were achieved. The LOD of the method developed was found to be 19 ng/mL, and the LOQ determined was 58 ng/mL. The study was further extended to know any Drug-Excipient interaction to prove that there is no interference between the excipients and Mafenide hydrochloride in a spray formulation.
LncRNA MEG3 regulates ASK1/JNK axis-mediated apoptosis and autophagy via sponging miR-23a in yak granulosa cells
Authors: Han Xiao-Hong , Pan Yang-Yang , Fan Jiang-Feng , Wang Meng , Wang Li-Bin , Wang Jing-Lei , Afedo Seth Yaw , Wang Ya-Ying , Zhao Ling , Zhao Tian , Zhang Tong-Xiang , Zhang Rui , Cui Yan , Yu Si-Jiu
Published: December 2022

Apoptosis and autophagy in granulosa cells (GCs) are highly related to follicular development and atresia. LncRNA MEG3, miR-23a, and apoptosis signal-regulating kinase 1 (ASK-1) have also been reported to be associated with apoptosis and autophagy. However, their relationship to follicular development and the extent to which follicle stimulating hormone (FSH) or luteinizing hormone (LH) can regulate this process remains unknown in yak GCs. Here, the effect of LncRNA MEG3 / miR-23a on apoptosis and autophagy via ASK1 (Apoptosis signal-regulating kinase 1) / JNK (c-Jun N-terminal kinase) in yak GCs were studied. Overexpressing LncRNA MEG3 reduced miR-23a levels and p-967 protein expression, but enhanced ASK1 and JNK mRNA levels as well as t-ASK1, p-845, t-JNK, and p-JNK proteins levels, and promoted apoptosis while attenuating autophagy. Then, the interaction between LncRNA MEG and miR-23a and both miR-23a and ASK1 via dual-luciferase reporter assay was also confirmed. The relationship between LncRNA MEG3 and miR-23a was observed as a negative feedback regulation for ASK1/JNK axis via pcDNA3.1-MEG3 or miR-23a transfection which mimicked alone or in co-transfection. In addition, FSH (10 μg/mL) or LH (100 μg/mL) ability to reverse the effects of LncRNA MEG3 on miR-23a levels and ASK1/JNK axis-mediated apoptosis and autophagy was verified in yak GCs. This is significantly beneficial for decreasing abnormal follicular atresia.
Facile hydrothermal synthesis of N-doped commercial activated carbon for zinc ion hybrid supercapacitor
Authors: Zhao Qian , Wang Yang , Xie Xingchen , Yu Chongyan , Gong Xinyu , Wang Ni
Published: December 2022

A one-step hydrothermal method was employed to treat commercial activated carbon (AC) with sodium azide as the nitrogen source. The characterizations confirmed the successful incorporation of N dopant into the surface of commercial activated carbon (NAC) and the increase in specific surface area, which indicates that nitrogen-doped activated carbon has excellent properties in ion adsorption and electron transfer. An NTC-based aqueous zinc ion hybrid supercapacitor (ZHS) is fabricated and shows an energy density of 232.4 Wh kg-1 at 0.1 A g-1 with a voltage window of 2.0 V and long-term GCD stability up to 10000 cycles. Considering the low-cost raw materials and surface modification at a relatively low temperature, the proposed technical route can be viewed as a promising method for the modification of carbon-based materials and application in next-generation energy storage devices.
Survival benefit with re-resection and optimal time to re-resection in gallbladder cancer: a national cancer database study
Authors: Shah Shivani , Sweeney Ryan , Wegner Rodney E
Published: December 2022

Purpose: Gallbladder cancer is often diagnosed incidentally after cholecystectomy. Most patients will then undergo re-resection for potential residual disease, however overall survival (OS) benefit data in this scenario is variable. In this National Cancer Database analysis (NCDB) we compare OS in patients diagnosed with T1b – T3 gallbladder cancer who underwent re-resection and evaluate if time to resection impacts OS.
Methods: We reviewed the NCDB for patients who had received initial cholecystectomy for gallbladder cancer and were subsequently eligible for re-resection based on tumor stage (T1b-T3 disease). Patients with re-resection were subdivided into four cohorts based on time to re-resection: 0-4 weeks, 5-8 weeks, 9-12 weeks and >12 weeks. We used a Cox proportional hazards ratio to identify factors associated with worse survival and logistic regression to evaluate characteristics associated with re-resection. OS was calculated using Kaplan Meier curves.
Results: 791 (5.82%) patients received re-resection. Cox proportional hazards analysis showed a Comorbidity Score of 1 was associated with worse survival. Patients with higher Comorbidity Scores and treatment at comprehensive community, integrated or academic cancer programs were less likely to undergo re-resection. Re-resection showed significantly improved OS [HR 0.87; 95 CI 0.77-0.98; p=0.0203]. Significantly improved OS was noted when re-resection was completed at 5-8 weeks, 9-12 weeks, or >12 weeks.
Conclusion: Optimal timing to re-resection in gallbladder cancer supports previous data showing benefit at >4 weeks. However, there was no significant survival difference as to whether re-resection was completed at 5-8 weeks, 9-12 weeks, or > 12 weeks post initial cholecystectomy.
Forest landscape dynamics after large-scale fires in western Patagonia: evidencing surprising temperate forest recovery trends
Authors: Hernández-Moreno Ángela , Soto Daniel P. , Miranda Alejandro , Holz Andrés , Armenteras-Pascual Dolors
Published: December 2022

Context
Western Chilean Patagonia is an isolated temperate region with a proportion of IFL that was subjected to large-scale fires over 60 years ago. However, there is no empirical evaluation of the land cover dynamics to establish the forest loss and recovery rate and the effect on the landscape structure and function, and remanent IFL following the fires.
Objectives
The present study addressed the following questions: (1) What have been the main trends of the land cover dynamics between 1984–2018 after earlier fires, and how have these trends shaped the spatial patterns and potential carbon stock of forests in the western Patagonia landscape? (2) What proportion of forest landscape remains intact following fires in this region?
Methods
We selected the Coyhaique Province (1,231,910 ha) in western Chilean Patagonia as the study area. Land cover maps for three dates (1984, 2000, 2018) were used to evaluate the landscape dynamics after fires. A map of persistence and change occurrence was made to estimate the IFL area over the 1984–2018 period. Landscape metrics were used to assess landscape structure change, and potential carbon stock was based on a literature review.
Results
Following fires, the main land cover changes between 1984–2018 were loss of ~ 32,600 ha of old-growth forest and a recovery of ~ 69,000 ha of second-growth forest. The increase in second-growth forest area mainly resulted from trajectories originating from agricultural cover, which lost ~ 41% of the area. Despite these changes, ~ 61% of the area could potentially remain as IFL after fires. Over the 1984–2018 period, a slight increase in fragmentation of old-growth forest, and a decline in second-growth forest were found. Coyhaique Province, experienced a slight increase (3.6%) in overall potential carbon stock maybe as a result of second-growth forest recovery.
Conclusions
Our study provides key evidence for understanding spatial patterns of forest recovery following chronic fires, which is crucial for predicting forest landscape resistance to anthropogenic disturbances in one of the few temperate regions with forest recovery in the southern hemisphere.
Based on the seismic records of different sensors, the relationship between pressure, acceleration and, velocity in shallow water is studied through waveform similarity
Authors: Zhen JIN , HuiTeng CAI , LanJie ZHOU , ShanHu LIU , GuoPing ZHANG
Published: December 2022

All ocean countries in the world attach great importance to research in the field of ocean observation. In the past 60 years, the United States and Japan have continued to promote the development of ocean seismic observation. In addition to 51 offshore island and reef stations, marine seismic observation stations in China are almost blank. As the first undersea earthquake station in China, the Wuyu Island submarine seismic station has recorded more than 100 earthquakes after a year of operation. It is found that the hydrophone signal recorded by Wuyu Island submarine seismic station OBS05 is very similar to the broadband velocity seismometer signal. We selected 10 typical events with a magnitude greater than three and the analysis shows that the hydrophone signal recorded by OBS05 is a strong correlation to the signal of the broadband velometer Z component. In view of the similarity of signals from different sensors, we first conducted correlation analysis in the time and frequency domain for the same ground-based velocity sensor and acceleration sensor on land and summarized the steps, methods, and influencing factors of correlation analysis. Finally, the waveform similarity among hydrophones, velocity, and acceleration sensors recorded by background noise and natural seismic data is comprehensively analyzed and further discussed when it is applied to a submarine seismic station.
Investigate the constituents of commercially available toothpastes
Authors: Ucuncu Musa Kazim , Guven Kerem , Yazicioglu Oktay
Published: December 2022

Toothpaste is one of the most significant tools and contains a great number of ingredients for eliminating dental plaque, which triggers periodontal disease and dental caries, from the hard tissues of the teeth, and is an essential component of oral and dental hygiene practices. With these ingredients, which are composed of several active or inactive components, issues such as cavities, tartar, and malodor can be addressed. In addition, the building blocks in their structures, the majority of which are considered inactive agents, can boost the efficacy of the therapeutic drug in the paste or protect it from external causes. However, some of these substances pose a threat not only to oral health, but also to the health of the entire body, causing tissue damage. In this study, the components of toothpastes in market aisles were analyzed, and their frequency of occurrence among pastes was found.
Modelling monthly patterns in regional rainfall for the United Kingdom: a time series analysis of the Rainfall Rescue data
Authors: Mills Terence C
Published: December 2022

In March 2020 the Rainfall Rescue project was launched on the Zooniverse platform with the aim of transcribing 66,000 sheets of rainfall observations into digital form. The associated website, RainfallRescue.org, received widespread media interest and, within 16 days, the complete set of sheets had been digitised by over 16,000 volunteer ‘citizen scientists’. The project has led to new monthly rainfall estimates for the U.K. and its ten regions being made available to download and time series analyses of these new rainfall data are reported in this paper. Using a seasonal linear trends model fitted to power transformed rainfall data, it is found that over the period 1836 to 2021 winters have become progressively wetter and fluctuations in monthly rainfall more pronounced the further west and north you move in the U.K., with little or no change in summer rainfall.
New chemical tools to study RNA distribution in neuronal cells
Authors:   , Klimek Robin
Published: December 2022

The most versatile tool for visualizing endogenous RNA is molecular beacons (MBs). MBs are modified oligonucleotides that consist of a stem-loop structure equipped with a fluorophore and a quencher at the opposite ends. They only give a fluorescent signal when hybridized to the target RNA. Here we present our recent efforts to enhance the spatiotemporal resolution of RNA visualization by refining MBs. We first asked if we could refine MBs to visualize defined subcellular populations of RNA in living neurons. To achieve this, we utilize visible light-activatable Q-dye MBs to allow only a subcellular fraction to be activated. Here, the fluorophore at the 5’-end was linked to a second quencher via a photolabile coumarin protecting group. Therefore, the MB only gives a fluorescent signal, when activated with visible light and hybridized to the target. This architecture allowed local activation of a hybridized subpopulation in a defined area of the cell. Knowing the exact origin of the activated RNA, we were able to increase the available monitoring time for neuronal mRNA from several minutes (literature known MBs) to more than 14 hours. We next asked if it would be possible to gain spatiotemporal control over where the MB hybridization events occur. Therefore, we developed photo-tethered MBs where two phosphates in the loop backbone are covalently linked to each other via two photocages. This prevents the MB from hybridization to the target RNA. Only when light is applied, the photo-tethers are cleaved, and the inherent hybridization function of the MB is activated. This architecture allowed us to control the hybridization of photo-tethered MBs in primary cultured neurons.
Differences in Nutrient Uptake Can Influence the Performance of Citrus Rootstocks under Huanglongbing Conditions
Authors: Ghimire Lushan , Grosser Jude , Vashisth Tripti
Published: December 2022

Huanglongbing {HLB [Candidatus Liberibacter asiaticus (C Las)]} has been one of the biggest challenges in citrus (Citrus sp.) production in Florida and wherever it is present. HLB-affected trees show significant shoot and root dieback, fruit drop, and reduction in yield. Currently, there is no cure for HLB, and there is no commercial HLB-resistant germplasm. Nonetheless, intensive nutrient management has been promising for citrus growers. The nutrient requirement of HLB-affected trees seems to be greater than that of healthy citrus trees. By understanding the nutrient uptake potential of rootstocks, fertilizer programs can be customized accordingly to enhance the performance of a rootstock in existing groves. Moreover, a reduction in the application of nutrients is possible by planting rootstocks with a high nutrient absorption capacity. Use of rootstocks with good nutrient uptake efficiency can take some burden off the growers who are intensively managing HLB-affected citrus groves. Therefore, the objective of this study was to evaluate and understand the nutrient uptake potential of the citrus rootstocks. To achieve this objective, a 100% hydroponic greenhouse study was conducted with six rootstocks with a range of tolerance to HLB. Several physiological and molecular tools were applied to evaluate the rootstocks for their nutrient uptake potential. A+Volk × O-19 (HLB-tolerant) rootstock had greater nutrient uptake efficiency, whereas US-896 (HLB-susceptible) had lesser nutrient uptake efficiency. Swingle, one of the most popular pre-HLB rootstocks, had poor zinc uptake and the least expression of ZINC TRANSPORTER, suggesting that zinc applications should be emphasized in Swingle plantings. US-896 rootstock expressed the least level of nutrient transporter genes, such as IRON TRANSPORTER. UFR-4 (a good performer under HLB conditions) had a large root biomass, but the uptake efficiency for nutrients was poor, suggesting that the nutrient uptake potential is a complex process that is not solely dependent on root biomass. This study is unique because it is one of the first citrus studies to report nutrient uptake efficiency and the potential of rootstocks. The information presented can be used to improve performance or select better-performing rootstocks under HLB conditions.
Effect of Pectin Coatings Containing Trans-cinnamaldehyde on the Postharvest Quality of Rambutan
Authors: Sun Xiuxiu , Wall Marisa , Follett Peter , Liang Peishih , Xu Sai , Zhong Tian
Published: December 2022

Rambutan (Nephelium lappaceum L.) (Sapinadeae) fruit, a nutritional staple in Hawaii, exhibits desiccation and physiological browning soon after harvest, and methods to prolong shelf life may be commercially advantageous. In this study, freshly harvested fruit were treated with pectin coatings with or without trans-cinnamaldehyde (TCIN) and stored at 10 °C or 20 °C (room temperature) to evaluate postharvest quality attributes. Control fruit were treated with deionized water only. To find the best formulation of the coatings, three concentrations of TCIN were incorporated into a pectin solution to get 0.05% TCIN, 0.1% TCIN, and 0.2% TCIN coatings. At 0, 2, 4, and 6 days postharvest, fruit stored at 20 °C were evaluated for weight loss, firmness, pericarp browning, sugar, acid, and taste. The results showed that the 0.1% TCIN coating exhibited significantly lower weight loss than both control and the 0.2% TCIN coating through the entire storage time at 20 °C. The 0.1% TCIN coating–treated fruit were significantly firmer than control after 4 days of storage at 20 °C. The 0.1% TCIN coating also significantly reduced the pericarp browning over the control. Therefore, we selected 0.1% TCIN coating for fruit storage at 10 °C for up to 15 days. At 10 °C, the control fruit showed significantly higher pericarp browning than all TCIN-containing coated fruit. The 0.1% TCIN-treated fruit showed a significantly higher overall quality value than control fruit. The results indicate that the 0.1% TCIN coating may extend the commercial shelf life of rambutans and other perishable fruits. By extending shelf life, this coating can reduce postharvest losses and facilitate expanded fruit exports in Hawaii.
THE IMPLICATION: IMPLEMENTATION PSAK 72 ON CORPORATE TAX 2019-2020
Authors: Solekha Yasmin Afnan
Published: December 2022

Tujuan penelitian untuk mengetahui dampak penerapan PSAK 72 pada implikasi pajak perusahaan 2019-2020. Metode penelitian menggunakan pendekatan kuantitatif melalui jenis korelasional. Populasi berjumlah 89, sampel diambil dengan teknik purposive sampling, didapatkan 32 sampel. Instrumen penelitian berupa dokumen, dianalisis menggunakan metode statistika inferensial, dengan uji normlitas dan uji wilcoxon. PSAK 72 mengatur pengakuan pendapatan dari kontrak dengan pelanggan. Menghapus konsep income accrual dan basic cash. Pendapatan diakui jika kewajiban telah terpenuhi. Mengakibatkan entitas mengalami penurunan pendapatan sebab banyak kontrak jangka panjang yang masih terjalin namun pada waktu yang akan datang pendapatan akan melonjak tinggi. Hasil penelitian, penerapan PSAK 72 berdampak pada implikasi pajak, berpengaruh pada pengakuan dan pembayaran pajak penghasilan badan. Terdapat disparitas pajak fiskal dengan pajak akuntansi, sebab konsep perolahan pada pajak fiskal sudah ditinggalkan dalam PSAK 72. Adanya disparitas ini tidak menutup entitas untuk tidak mematuhi pajak, sehingga konsekuensi yang harus dihadapi yakni adanya akselerasi pengakuan pajak. Pajak penghasilan badan diakui dan dibayarkan lebih cepat dibanding pendapatan yang belum diterima. SPT yang dilaporkan tetap berpedoman pada aturan fiskal. Jika tidak, kemungkinan entitas akan menerima denda dan sanksi atas ketidakpatuhan dalam pembayaran pajak
Tuberculosis situation in children in 2021 and the prospects of its change in 2022
Authors: Aksenova V. A. , Sterlikov S. A. , Kucheryavaya D. A. , Gordina A. V. , Pankova Ya. Yu. , Vasilyeva I. A.
Published: December 2022

The article analyzes changes in the epidemic tuberculosis situation in children and factors inﬂuencing it. Data from tuberculosis statistical surveillance forms and on-line monitoring data for the biggest available period were studied. It was found that in 2021, tuberculosis incidence increased in children of 0-14 years old, and this increase was statistically signiﬁcant (p < 0.05) in the group of children of 7-14years old (from 5.6 to 6.3 per 100,000 children of 7-14 years old), which may be related to the COVID-19 pandemic: increased epidemic risk of tuberculosis infection sources and increased exposure of children primarily of school age, who were switched to distant learning.

The increase in tuberculosis incidence among children exposed to tuberculosis patients from 143.8 to 183.0 per 100,000 exposed children may be further attributed to decreased dissociating of contacts by hospitalizing children to tuberculosis sanatoria. Theepidemic tuberculosis situation in children is expected to deteriorate due to increased migration from the country with an unfavorable tuberculosis situation, i.e. Ukraine. Tuberculosis mortality in children continued to decline; there were no signs that it would increase in 2022.
Groups at high risk of developing respiratory tuberculosis among adult population of Kaluga Oblast
Authors: Lapshina I. S. , Tsybikova E. B. , Kotlovskiy M. Yu.
Published: December 2022

The objective: to determine groups at high risk of developing tuberculosis (TB) among adult population of Kaluga Oblast.

Subjects and Methods: data from Federal Statistical Surveillance Forms no. 8, 33, 12, 36, and 37 for 2015-2021, Rosstat data on the population of Kaluga Oblast. Pearson's chi-square test (χ2) was used for data analysis.

Results. Among adult population, 8 groups facing the high risk of developing tuberculosis have been identiﬁed: HIV-positive individuals, people exposes to tuberculosis patients with a positive result of sputum testing, drug users, inmates staying in institutions of the Federal Penitentiary Service, individuals not screened for ≥ 2 years, homeless, migrants, and persons with alcohol addiction.

According to results of analysis of factors that had a negative impact on the course of respiratory tuberculosis, the highest risk of developing a severe course was registered only in groups at advanced risk of tuberculosis: HIV-positive individuals, drug users, persons with alcohol addiction, homeless, individuals not screened for ≥ 2 years, and people exposes to tuberculosis patients with a positive result of sputum testing.
Screening for tuberculosis infection in children and adolescents by two intracutaneous tests: with tuberculin and tuberculosis recombinant allergen (ESAT-6/CFP-10) in Moscow in 2021
Authors: Bogorodskaya E. M. , Slogotskaya L. V. , Shamuratova L. F. , Sevostyanova T. A.
Published: December 2022

The objective: to evaluate eﬀectiveness of mass screening for tuberculosis infection in children and adolescents in Moscow using two diﬀerent options according to age; to determine impact of the COVID-19 pandemic on eﬀectiveness of screening campaign judging by incidence rates in children and adolescents.

Subjects and Methods. In 2021, 758,634 children aged 0-7 years, or 99.2% of those to be screened, were screened using the Mantoux test. Should the reaction increase compared to the previous year, an additional test with the tuberculosis recombinant allergen (TRA) was performed. Children of 8-17 years old were screened only with TRA test. 1,070,961 people were examined, or 97.9% of those to be examined.

Results. It has been demonstrated that the test with TRA can be used as a screening tool and eﬀectively identify patients with a high risk of tuberculosis development. The preventive therapy received by those positively responding to TRA test resulted in almost no disease in them. The predominance of new cases with post-tuberculosis changes over new cases of active tuberculosis while the number of both is decreasing indicates the ability of the methods (TRA together with computed tomography) to detect minor forms of the active disease and post-tuberculous changes. In 2021 versus 2020, the number of children diagnosed with tuberculosis did not statistically signiﬁcantly increase because of those who failed to be detected in 2020 due to incomplete coverage with screening related to spread of COVID-19. However, in 2021 the rates were lower than in 2019 which conﬁrmed their positive change.

Conclusion: Screening with TRA test is eﬀective, easy to perform and can be used in primary health care.
PEMBENTUKAN PENYULUH SEBAYA GUNA PENINGKATAN PENGETAHUAN PELAJAR SMA TERKAIT PENCEGAHAN COVID-19 DI KOTA YOGYAKARTA
Authors: Sira Amaze Grace , Periska Septian Dewi , Andrea Patricia Dissy
Published: December 2022

Covid-19 telah menyebar ke berbagai negara di dunia, termasuk Indonesia. Pemerintah banyak menerapkan peraturan terkait penyegahan Covid-19, dengan 5M yaitu memakai masker, mencuci tangan pakai sabun dan air mengalir, menjaga jarak, menjauhi kerumunan, serta membatasi mobilisasi dan interaksi serta diupayakannya percepatan Vaksinasi Covid-19. Dengan adanya kelompok remaja yang sadar akan pentingnya vaksin Covid-19 maka para remaja tersebut dapat menjadi role model dalam memberikan informasi kepada teman sebayanya. Tujuan dari Program Pengabdian Masyarakat ini bertujuan membentuk penyuluh sebaya guna menjadi role model bagi remaja untuk meningkatkan pengetahuan remaja terkait 5 M dan Vaksinasi Covid-19. Tema yang diusung adalah Prajurit X Korona “Pelajar maju rintangi korona”. Metode yang dipakai adalah dengan melakukan observasi lapangan dilakukan di empat SMA di Yogyakarta dan melakukan komunikasi dengan sekolah untuk memilih 4 siswanya yang akan dibina sebagai penyuluh sebaya. Dilakukan pelatihan kepada para penyuluh sebaya dengan materi Covid-19, 5M dan Vaksinasi Covid-19 serta Public Speaking. Setelah dilakukan kegitan disampaikan bahwa pelajar merasa terbantu dengan adanya pelatihan ini.
Copper(II) hydroxide/oxide-coated granular activated carbon forE. coliremoval in water
Authors: Li Yali , Deletic Ana , Henry Rebekah , Zhang Tong H. , McCarthy David T.
Published: December 2022

Low-cost granular filter media with hybrid bacterial adsorption and survival inhibition capability is highly desired for the development of a low-impact water filtration system. In addition to overall removal, a deeper understanding of the fate and transport behaviour of bacteria in such systems should also be obtained to guide system operation. In this study, copper(II) hydroxide nanoparticles-modified granular activated carbon via a single-step in situ coating was prepared and denoted as CuH-G. Copper release behaviour and Escherichia coli removal efficiency of CuH-G were studied in saturated columns as a function of salinity, flow rate, and hydraulic loading. Copper release decreased exponentially on increasing salinity in test water, which potentiates controlled copper release for desired bacteria inhibition efficiency. With an effective contact time of 3.7 min, CuH-G provided 3.0 and 1.6 log E. coli removal in test water of salinity 237 and 680 μS/cm, respectively. Copper leaching at these two salinities were 1.7 and 0.74 mg/l, respectively below the Australian Guidelines for Water Recycling: Augmentation of Drinking Water Supplies. Further study of E. coli transport and deposition behaviour in heat-treated CuH-G at 160 °C revealed that the observed removal was largely attributed to enhanced attachment during filtration and survival inhibition post filtration.
Energy cost optimization of groundwater treatment using biochar adsorption process: An experimental approach
Authors: Yapıcıoğlu Pelin , Yeşilnacar Mehmet İrfan
Published: December 2022

This study has aimed to reduce the energy costs using agricultural waste derived (pistachio shells) biochar application for groundwater treatment. An energy cost indicator has been figured out applying a new quantitative approximation. Data envelopment analysis (DEA) has been applied to optimize the energy costs of groundwater treatment. Energy costs assessment of groundwater treatment has been carried out with regards to nitrate (NO3−), fluoride (F−), boron (B), iron (Fe (II)) and lead (Pb) removal for March (before irrigation) and October (post irrigation) related to 10 observation points in an arid and semi-arid area. When lead removal leads to the highest energy costs in the plant, nitrate removal has the lowest energy costs. The total energy costs would be reduced averagely at 44.5 and 52.5% in March and October, respectively when biochar adsorption was applied in the plant. According to the DEA model, the optimum energy consumption belongs to biochar adsorption in terms of fluorite removal with the value of 434.95 kWh/d. According to DEA analysis, NO3− is a low energy-intensive parameter and Pb is a high energy-intensive parameter. The results of the DEA model have been overlapping with the energy cost indicator.
Antifouling and antibacterial performance evaluation of polyethersulfone membranes modified with AZ63 alloy
Authors: Ozay Yasin , Alterkaoui Aya , Kahya Kürsat , Özdemir Sadin , Gonca Serpil , Dizge Nadir , Ocakoglu Kasım , Kulekci Mustafa Kemal
Published: December 2022

Antibacterial membranes have attracted researchers’ interest in recent years as a possible approach for dealing with biofouling on the membrane surface. This research aims to see if blending AZ63 Mg alloy into a polyethersulphone (PES) membrane can improve antifouling and separation properties. The composite membranes’ pure water flux continued to increase from pristine PES to PES/AZ63 2.00 wt%. The results showed that PES/AZ63 2.00 wt% membrane supplied the highest permeate flux of E. coli. The steady-state fluxes of AZ63 composite membranes were 113.24, 104.38 and 44.79 L/m2h for PES/AZ63 2.00 wt%, 1.00 wt%, and 0.50 wt%, respectively. The enhanced biological activity of AZ63 was studied based on antioxidant activity, DNA cleavage, antimicrobial, anti-biofilm, bacterial viability inhibition and photodynamic antimicrobial therapy studies. The maximum DPPH scavenging activity was determined as 81.25% with AZ63. AZ63 indicated good chemical nuclease activity and also showed moderate antimicrobial activity against studied strains. The highest biofilm inhibition of AZ63 was 83.25% and 71.63% towards P. aeruginosa and S. aureus, respectively. The cell viability inhibition activity of AZ63 was found as 96.34% against E. coli. The photodynamic antimicrobial therapy results displayed that AZ63 demonstrated 100% bacterial inhibition when using E. coli.
Therapeutic efficacy of marbofloxacin and ceftiofur in feedlot steers with bovine respiratory disease complex
Authors: Lapczak Jéssica Cristina de Oliveira , Rossi Patricia Santos , Thomaz Gabriela Rodrigues , Garbossa Gabriela , Neumann Mikael , Bertagnon Heloisa Godoi
Published: December 2022

Treatment of the bovine respiratory disease complex (BRDC) can elicit high bacterial resistance and stress to steers in a feedlot. Therefore, the present study aimed to evaluate three therapeutic protocols with long-acting antibiotics against BRDC naturally acquired in steers finished in feedlot. In a total of 80 animals finished in a feedlot, 18 steers showed clinical signs compatible with BRDC (mucopurulent nasal secretion, lung auscultation alteration, leukocytosis, and decrease of dry matter intake). These animals were randomly treated: marbofloxacin in a single dose (M1), marbofloxacin in two doses (M2), or ceftiofur in a single dose (C1) on Day 0. The clinical score of pneumonia, hemogram, daily food intake, and body weight were analyzed during 7 days. On slaughter day (Day 100), the body weight and frequency of lungs with pneumonia was evaluated. On Day 7, M2 showed absence of pneumonia, and M1 and C1 still showed a clinical score of mild pneumonia (P = 0.01). On day 2 and day 3 M2 showed a higher dry matter intake than others treatments (P = 0.05). C1 showed a lower body weight than others group on day 1 and 2 (P = 0.05). The C1 and M1 showed a higher pneumonia frequency than M2 (P = 0.02). The M2 slaughter weight was numerically higher than the other treatments. We conclude the marbofloxacin in two doses eliminated the pneumonia ́s clinical symptoms and allowed the animals to return the productivity earlier than other protocols.
Serological detection of Brazilian Spotted-Fever Group Rickettsiae in horses in Brasília, Federal District, Brazil
Authors: Martins Gustavo Pereira , Silva Alice Martins da , Vieira Yara Cavalcante , Rocha Gino Chaves da , Gazêta Gilberto Salles , Perecmanis Simone
Published: December 2022

Brazilian spotted fever (BSF) is a zoonosis caused by spotted-fever group Rickettsiae that is transmitted to humans through tick bites. Dogs and horses are considered to be sentinel animals for this disease. In this study, a serological survey was carried out among horses apprehended by the governmental animal control service of the Federal District, Brazil. Serum samples were obtained from 122 horses over a one-year period. Through the indirect immunofluorescence antibody assay (IFA) for Rickettsia rickettsii anti-IgG antibodies, 21 samples were found to be positive, with titers ranging from 1:64 to 1:512. This demonstrates that the agent presents silent circulation in the Federal District.
The Correlation between Adiponectin and Endothelin-1 Systemic levels with Normal-Tension Glaucoma in Metabolic Syndrome Patients
Authors: Seskoati Prayitnaningsih , Virna Oktariana , Synthia Nusanti , Budi Siswanto Bambang , Anwar Santoso
Published: December 2022

Background:

The pathomechanism in Normo-tension glaucoma (NTG) is a dysregulation in the optic nerve head, which also occurs in Metabolic syndrome (MetS). Current therapies such as lowering intraocular pressure (IOP) have failed to inhibit the progression of NTG. This encourages various studies to evaluate the role of MetS.

Objective:

This study aims to evaluate the possible role of ET-1, TBARS, FRAP, hsCRP, Adiponectin, and Leptin systemic levels in the pathogenesis of NTG in MetS patients.

Methods:

This is a cross-sectional study conducted at the National Cardiac Center, Harapan Kita Hospital, Indonesia, with 29 patients divided into two groups, namely, with NTG (n=15) and without NTG (n=14). MetS was diagnosed based on the 2006 IDF criteria, while NTG was determined based on the presence of IOP, MD of the visual field, RNFL, and cupping of the disc as assessed by OCT. Furthermore, plasma ET-1, hsCRP, Leptin, and Adiponectin were assayed by ELISA, FRAP and TBARS were measured by colorimetric assay, while comparative and correlative tests were also performed.

Results:

There was a positive significant correlation between ET-1 and MD in NTG group (p = 0.025 ; r = 0.416 ; CI 95%= 1.85±0.89) as well as adiponectin and RNFL thickness (p = 0.035 ; r = 0.392 ; CI 95% = 2.71±8.27), however, a negative correlation was found between Adiponectin and MD (p = 0.012 ; r = -0.459 ; CI 95% = 5.53±18.68). Furthermore, there were no statistical differences in TBARS, FRAP, hsCRP, and leptin levels between the 2 groups.

Conclusion:

Based on the results, Adiponectin and ET-1 have potential involvement in the pathogenesis of NTG in MetS patients.
Temporal Variation in Abundance and Distribution of Butterflies in a Southern Nigerian National Park
Authors: Ojianwuna Chioma C. , Umoru Polycarp A.
Published: December 2022

Aims:

The aim of this study was to determine the butterfly diversity in Okomu National Park, Nigeria in order to make available information on butterfly species in this protected areas.

Background:

Butterflies are a taxonomically important group for predicting the health of the environment.

Objective:

In order to establish butterfly abundance and distribution in Okomu National Park, a temporal variation study was conducted for a period of twenty-four months (July 2012 to June 2014).

Methods:

Eight transects (Disturbed habitat (DIS), Forest Edge/Plantation (FE/P), Moderately Open Forest (MOF), Forest Along Road/Moist Patches (FAR/MP), Riparian Habitat (RIP), Closed Canopy (CC), Shrub (SHR) and Grassland (GRA) were mapped out from the four ranges (Igwonwan, Arakhuan, Julius Creek and Babui) from visual level of disturbance and degree of canopy closure for transect walk, butterfly net and baited trap methods of butterfly sampling. Environmental variables (temperature, relative humidity, and rainfall) were concurrently sampled with butterflies.

Results:

A total of 143 species and 6,310 individuals of butterflies were obtained from the families; Nymphalidae, Papilionidae, Pieridae, Lycaenidae, and Hesperiidae. Nymphalid (3103: 49.2%) and Pieridae (2269: 36.0%) predominated and Hesperiidae was recorded low (8: 0.1%). Significant differences were observed in the abundance of butterflies in the transects (p< 0.05). Rainfall was positively correlated with butterfly abundance. Butterfly abundance was higher in rainy season compared to dry season except in RIP where a reverse trend was observed. Abundance was higher in FAR/MP (1633: 25.9%) and MOF (1251: 19.8%) compared to other transects, and was lowest in SHR (295: 4.7%).

Conclusion:

It can be concluded that butterfly in Okomu forest is abundant and stable, and as such continuous effort is required to conserve butterfly flora and fauna in this park.