bluuebunny/crossref_metadata_2025 huggingface dataset:
Chekhov’s context in Mikhail Zoshchenko’s ‘Sentimental Tales’
Authors:   Saint Petersburg State University, Bao Tingting
Published: December 2022

Mikhail Zoshchenko’s Sentimental Tales are organized as a pyramid where each level is consistent and connected with the previous ones and with Russian classic literature. One of the writers who most influenced Zoshchenko was Anton Chekhov. Their creative similarity is manifold: the poetics of daily life, the image of the little man they wrote about, the lyrical humor, the existential problems they raised. The present study provides a comprehensive analysis and an intertextual comparison of M. Zoshchenko’s and A. Chekhov’s poetics. The paper aims to identify how Zoshchenko employs and transforms Chekhov’s principle of discovery story and to determine the meaning-forming functions performed by intertexts. The analysis revealed that M. Zoshchenko’s Sentimental Tales are to a great degree based on Chekhov’s discovery story genre. The theme of sudden insight, the it seemed versus it turned out compositional principle, existential problems, man-in-a-case complex continue the literary succession and offer new opportunities for the interpretation of Zoshchenko’s prose. Characters created by Zoshchenko represent the average intellectual type of the last century. The tragedy lies in the fact that their world no longer exists, and fate is irreversible, thus the intellectuals become senseless martyrs, victims of the change of epoch. Whether the characters are aware of this problem or not, being the subjects of orientation in reality, they inevitably plunge into a dead end of cognition of being. Consequently, fears, loneliness, lack of understanding, perplexity, disunity, communication failure acquire depth in M. Zoshchenko’s tales. The paper evidently demonstrates the authors sympathy for intellectuals he writes about. Existential pathos, eternal powerlessness of the thought and action, pathos of the impossibility of returning to the past life, and fear of the unknown future, constitute the inner issues of Sentimental Tales and raise the stories to the philosophical level.
Zen Buddhist Motifs in A. Makushinsky’s novel ‘The Stopped World’
Authors:   Shenzhen MSU-BIT University, Dubakov Leonid V.
Published: December 2022

The article aims to comprehend the impact of Zen Buddhism, its philosophical positions and practices on the problems and poetics of the novel by A. Makushinsky The Stopped World. The Buddhist influence in the novel is manifested in the literary implementation of the principles of the emptiness of reality, the illusory nature of the human ‘I’, the relativity of time and space, and also in the features of the created characters, landscapes and interiors, in the organization of the chronotope. Based on the results of the study, it can be stated that in The Stopped World A. Makushinsky not only depicts the world perceived in meditation by means of a thorough and detailed analysis of all components of reality but also literally depicts the world from meditation. The writer draws attention to the principle of universal connections of things showing the similarities of various characters in the novel. The Stopped World is looking for parallels that would most adequately explain what Zen and human consciousness are. Such parallels are sky and water, photography, architecture. Each of them expresses the dynamics that have become static, the fuss that has become peace, or the ‘stopped world’. The theoretical and methodological base of the work rests on the research conducted by V. Toporov (on the ‘Petersburg text’) and P. Alexeev (on the ‘Muslim text’): the precedent translation of the structural-semiotic approach from the urban-cultural into the religious sphere allows us to apply it also to the literary study of the presence of Buddhist ideas and motifs in the text. The relevance of the article is determined by the low level of knowledge of the presence of Buddhism in Russian literature as one of the world religions and one of the traditional religions of Russia. The article is novel in that it attempts to provide a consistent and broad study of the ‘Buddhist text’ of modern Russian literature based on thenovel The Stopped World by A. Makushinsky taking into account the writer’s poetic work.
Pozitif psikolojik sermaye ve lider-üye etkileşiminin örgütsel vatandaşlık davranışı üzerindeki etkisi: bir araştırma
Authors: ÖRÜCÜ Edip , UZUNER Maida , HASIRCI Itır
Published: December 2022

Bu araştırmanın amacı, pozitif psikolojik sermayenin ve lider-üye etkileşimin, örgütsel vatandaşlık davranışı üzerindeki etkisini belirlemektir. Araştırmanın evrenini, Balıkesir’in Bandırma ilçesinde faaliyet gösteren Eti Maden işletmelerine ait Borikasit ve Boraks fabrikalarında çalışan 258 personel oluşturmakta olup, araştırmanın örneklemini ise bu fabrikalarda çalışan 202 personel oluşturmaktadır.Elde edilen verilerle frekans analizi, güvenirlik analizi, normallik testi, korelasyon analizi ve çoklu regresyon analizi yapılmıştır. Yapılan korelasyon analizinin sonucunda lider-üye etkileşimi ile pozitif psikolojik sermaye arasında pozitif yönlü ve anlamlı bir ilişki (r(202): 0,584, p<0,05) olduğu belirlenmiştir.Ayrıca lider-üye etkileşimi ile örgütsel vatandaşlık davranışı arasında pozitif yönlü ve anlamlı bir ilişki (r(202): 0,606, p<0,05), psikolojik sermaye ile örgütsel vatandaşlık davranışı arasında da pozitif yönlü ve anlamlı bir ilişki (r(202): 0,787 p<0,05)olduğu görülmüştür. Yapılan çoklu regresyon analizinin sonucuna göre, lider-üye etkileşiminin örgütsel vatandaşlık davranışı üzerinde pozitif yönlü ve anlamlı (β = 0,222, p<0,05) bir etkisinin olduğu görülmüştür. Pozitif psikolojik sermayenin ise örgütsel vatandaşlık davranışı üzerinde pozitif yönlü ve anlamlı (β = 0,657, p<0,05) etkisinin olduğu görülmüştür.
Osmanlı toplumunda sûfîlerin Ramazan bayramı adet ve gelenekleri
Authors: IŞIK Zekeriya
Published: December 2022

Osmanlı İmparatorluğu’nda sûfîlerin devlet ve toplumla ilişkileri, örgütlenme biçimleri, dini ve tasavvufi anlayışları, tekke ve zaviyelerin idari, mimari, sosyal ve ekonomik yapıları vb. konularda farklı disiplinlerden bir hayli çalışmanın yapıldığı görülmektedir. Ancak sûfîlerin gerek inanç ve zihin dünyaları gerekse sosyal çevreyle olan gündelik ilişkilerine dair son derece önemli bilgiler ihtiva ettiği anlaşılan başta Ramazan ve Ramazan bayramı olmak üzere kandil geceleri, Cuma ve aşure günleri, kurban ve cenaze merasimleri gibi hususlara dair çalışmaların daha az olduğu anlaşılmaktadır. Sûfîlerin Ramazan ayına ve oruç ibadetine büyük ehemmiyet verdikleri, derin zahiri ve tasavvufi anlamlar yükledikleri nihayet Ramazan bayramını da başta oruç olmak üzere yoğun bir şekilde ibadet ve taat ile geçirdikleri bu ayın bir hasadı olarak gördükleri anlaşılmaktadır. Tarikattan tarikata bazı usul ve kaideler değişmekle birlikte ortaya konulan uygulamaların ve geleneklerin anlam ve mahiyeti benzer olup aynı gayelere hizmet etmiştir. Bu nedenledir ki Ramazan bayramlarını, bayram gecesi, bayram namazı, bayramlaşma, türbe ziyaretleri, dergâhın bürokrasiye, halka ve ihvana açılması, ikramların yapılması, vaaz, sohbet, ibadet, ayin ve zikir gibi çok sayıda uygulamayı zamanla oluşan adet ve geleneği işe koşarak, manevi hissiyatın ve coşkunun olabildiğince yoğunlaştığı bir atmosferde ihya etmişlerdir. İşte bu çalışma tüm Müslüman toplumda olduğu gibi sûfîler arasında da büyük bir ehemmiyete haiz olduğu anlaşılan Ramazan bayramı olgusunu, gündelik yaşamlarına olan çok yönlü yansımalarını, bu zamanlarda kamusal alanla ve sosyal çevreyle geliştirdikleri ilişkilerin mahiyetini, gelenekselleşen adetlerini ortaya koymak amacıyla yapılmıştır. Konunun mahiyeti, kaynakların yetersizliği gibi etkenler çalışmanın dönemsel olarak sınırlandırılmasını zorlaştırsa da daha çok 19. yüzyıl ve sonrası esas alınmıştır.
Türkiye’de mevduat bankalarının kârlılığını, gelirlerini ve hisse değerlerini etkileyen faktörlerin oran analizi ve yapısal eşitlik modeli ile testi
Authors: ÖZÇELİK Musa
Published: December 2022

Bankacılık sektörü özellikle gelişmekte olan ülke ekonomileri için temel yapı taşlarından biri olup bu sektörün kârlılığı finansal gelişme için önem arz etmektedir. Özellikle Covid-19 pandemisi ile birlikte bankacılık sektörünün kârlılığı üzerinde etkili olan faktörlerin belirlenmesi daha fazla önem kazanmıştır. Bu çalışmanın amacı Türkiye’de faaliyet gösteren mevduat bankalarının kârlılıklarını, gelirlerini ve hisse değerlerini etkileyen unsurları tespit ederek optimum bir finansal yapı için öneriler sunmaktır. Bu doğrultuda Borsa İstanbul’da işlem gören dokuz adet bankanın 2014/03-2022/03 tarih aralığında üçer aylık dönemler halinde finansal tablolarından yararlanılarak oluşturulan oranlar çalışmanın veri setini oluşturmaktadır. Toplanan ikincil veriler SmartPLS programı aracılığıyla Kısmi En Küçük Kareler-Varyans Temelli Yapısal Eşitlik Modellemesi (PLS-SEM) analizine tabi tutulmuştur. Bulgulara göre büyüme oranlarının değerleme oranları üzerinde negatif yönde, kârlılık oranları üzerinde ise pozitif yönde etkisinin olduğu; değerleme oranlarının gelir oranları üzerinde pozitif yönde, kârlılık oranları üzerinde ise negatif yönde etkisinin olduğu; finansal yapı oranlarının değerleme oranları üzerinde pozitif, gelir oranları üzerinde ise negatif yönde etkisinin olduğu; özkaynak yeterlilik oranlarının kârlılık oranları üzerinde pozitif yönde etkisinin olduğu tespit edilmiştir.
Turizm ve rekreasyonda Richard M.Ryan ve Edward L.Deci’nin öz-belirleme teorisinin bibliyometrik analizi
Authors: ERŞAHİN Esra , GÜLCAN Bilgehan
Published: December 2022

Edward Deci ve Richard Ryan tarafından geliştirilen bireyin eylemlerini veya durumlarını herhangi bir dış baskı olmaksızın kendi başına belirlemesi olarak ifade edilebilen öz belirleme teorisinden, ağırlıklı olarak psikoloji ve eğitim alanında yararlanılmaktadır. Bunun yanı sıra, yeni bir teori olmasına rağmen, rekreasyon tercihlerinin anlaşılması ve açıklanması bakımından önemli bir rol üstlenmektedir. Çalışmanın amacı, Ryan ve Deci’nin öz belirleme teorisinden yararlanan çalışmaların bibliyometrik analizini yaparak, teoriye yönelik turizm ve rekreasyon alanında yapılan akademik çalışmaların sistematik bir biçimde değerlendirilmesi, teorinin kullanım sıklığını ortaya koyarak rekreasyon olguları ile ilişkisini ve yeterliliğinin açıklanması hedeflenmekte ve gelecek çalışmalar için yönlendirici katkılar sunmaktır. Çalışmanın örneklemini; Scopus veri tabanında, teorinin ortaya atıldığı 1980 yılı ile günümüz 2022 yılı arasında, “Öz belirleme Teorisi-Self determination Theory” ve “Ryan, Deci” anahtar kelimelerini “başlık” ve “anahtar kelime” olarak kullanan 8.849 adet çalışma oluşturmaktadır. Çalışma verilerinin analizinde, frekans analizinden ve VOSviewer istatistik programından yararlanılmıştır. Veriler farklı başlıklar altında sınıflandırılarak yorumlanmıştır. Çalışmada elde edilen bulgulara göre 1980-2022 yılları arasında, “Rekreasyon-Recreation” ve “Öz belirleme Teorisi-Self determination Theory” anahtar kelimelerinin kullanıldığı 514, “Turizm-Tourism” ve “Öz belirleme Teorisi-Self determination Theory” anahtar kelimelerinin kullanıldığı 438 çalışma tespit edilmiştir.
Citizen control monitor program and its contribution to the government control of public works
Authors: Valera Muñoz Francisco Javier
Published: December 2022

The Citizen Control Monitors Program is a citizen participation mechanism created by the Comptroller General of the Republic in 2018, based on Directive No. 004-2018-CG/DPROCAL, with the aim of establishing a mechanism for citizen oversight, mainly in the control of the execution of public works, within the framework of the Comprehensive Plan for Reconstruction with Changes, as a result of the devastating consequences of the phenomenon "El Niño Costero" of the year 2017. The objective of this article is to determine the Contribution of the Program to Government Control of Works in La Libertad. A systematic review and analysis of Control Services Reports issued as a result of visits made by monitors with Comptroller's staff was carried out. The results showed that 151 works were visited in La Libertad, from October 2018 to June 2022, the main adverse situations identified being the absence of the Supervisor in 21% of works, non-compliance with safety regulations with 28% and non-existence of the Work Book with 30%. Concluding that the Program does contribute to government control by detecting correctable adverse situations in time, in order to guarantee the achievement of the objectives of the Work.
Пожилой человек как субъект изучения, поддержки и общения
Authors: Подольский Андрей Ильич , Ермолаева Марина Валерьевна , Шоркина Надежда Андреевна
Published: December 2022

В книге раскрыта психологическая сущность старения, освещены современные отечественные и зарубежные исследования закономерных изменений личности, познавательных процессов, психических состояний, а также особенностей межличностных отношений пожилых людей. Она знакомит читателей с условиями высокой творческой продуктивности в старости, механизмами компенсации психических процессов в целях поддержания творческого потенциала и возможностями активной жизни после выхода на пенсию. В монографии подробно изложены основные методы и средства психологической поддержки пожилых: психосоциальной поддержки, психологического консультирования и психотерапии. В этом смысле книга представляет собой справочное издание по самому широкому кругу проблем практической психологии старения. Издание адресовано научным работникам и студентам, изучающим психологию развития человека в пожилом возрасте, практическим психологам, занимающимся психопрофилактикой старения и психологической помощью пожилым, а также врачам и социальным работникам.
Transglutaminase-induced corneal collagen cross-linking on the central cornea thickness and intraocular pressure in vivo v1
Authors: Hapsari Sitorasmi Puspita
Published: December 2022

Background: Corneal collagen crosslinking (CXL) is a procedure for making bonds that connect polymer chains to one another. Corneal CXL aims to slow or stop the progression of keratoconus by using photooxidative therapy so as to increase stromal rigidity. Transglutaminase enzymes are currently widely used in the food industry. Recent studies have shown that mRNA, fibronectin, and transglutaminase were found to be more abundant in human corneal keratocytes treated with UVA and riboflavin. Transglutaminase is considered to reduce discomfort caused by UVA irradiation. Methods: A total of 21 white New Zealand rabbits were divided into three groups, namely, transglutaminase-induced CXL group, epithelial-off CXL group, and transepithelial CXL group. The ocular surface was treated with a 1 U/mL microbial transglutaminase solution, and both the epithelial-off and transepithelial groups were exposed to clinical ultraviolet A-riboflavin (UVA/RF). The efficacy of each group was evaluated on the 14th day after the procedures. The central corneal thickness (CCT) and intraocular pressure (IOP) were evaluated using Corneal Visualization Scheimpflug Technology (Corvis ST). Results: The transglutaminase-induced CXL group exhibited the highest mean CCT (370.14 ± 38.85) in comparison with the UVA/RF epithelial-off group (368.00 ± 25.48) and the UVA/RF transepithelial group (369.86 ± 23.43). The transglutaminase-induced CXL group had the highest IOP mean (8.50 ± 3.02) compared with the UVA/RF epithelial-off (6.50 ± 3.07) and UVA/RF transepithelial groups (7.00 ± 1.90). There were no significant differences in CCT (p = 0.990) or IOP (p = 0.563) between the groups. Conclusions: The findings of this study suggest that there are no significant differences between the transglutaminase-induced CXL group and the UVA/RF CXL group. The safety of transglutaminase-induced CXL could be comparable to that of UVA/RF CXL in terms of altering CCT and IOP, which are two factors contributing to corneal rigidity
Processing Stack-of-Stars DCE Data v1
Authors: Zhou Rong
Published: December 2022

Step-wise protocol for reconstruction of Stack-of-stars acquired DCE series, T1 and B1 maps and PK (pharmacokinetic) modeling of DCE data using a reference region model is provided.
Total particulate carbohydrate from microalgae v1
Authors: Hu Ying-Yu
Published: December 2022

Here we describe a protocol to estimate the total particulate carbohydrate from microalgae. Carbohydrate samples are initially vortexed in 9 M H2SO4 for 15 s. The solution is diluted for a final H2SO4 molarity of 1.6 M and hydrolyzed for 3 hours at 90 °C. The hydrolysate is alkalinized by adding 12 M NaOH to the hydrolysate, the ratio of [H+] from the hydrolysate to [OH-] from NaOH is 0.82. The alkalinized hydrolysate is oxidized by ferricyanide solution. The absorbance of TPTZ-Fe2+ complex is measured in microtiter plate at 595 nm. Our method has shown high reproducibility in aldohexoses, ketohexoses, deoxysugars, aldopentoses, uronic acid and amino sugars. The linear range of response is between 0.18 to 10 µg C/mL.
Including the Experiences of Children and Youth in Media Education
Authors: Supa Markéta , Römer Lucie , Hodboď Vojtěch
Published: December 2022

This article explores how the concepts of inclusion and experience can be approached and applied in educating children and youth about the media. Using a multiple-case study approach, we present three cases where media education programs were delivered to students in the Czech Republic. The first case is a three-month-long program aimed at nurturing students’ media literacy and encouraging their civic participation. It involved 17 vocational school students (ages 17–19) at risk of social exclusion. The second case is a three-hour workshop promoting children’s cooperation with their peers and civic engagement with media in a diverse society tested with 60 children (ages 10–11) in three classrooms in two public elementary schools. The third is a year-long media education program based on students’ guided self-reflection on their media experiences, attended by eight students (ages 15–17) at a private high school. Despite numerous differences in the programs (goals, activities, duration, context, student demographics, etc.) and their varied approaches to promoting inclusivity and the whole student experience, we argue that each one has the potential to contribute to creating a more inclusive society that respects diversity. We also believe that longer programs would be more successful in supporting children and youths’ immediate and future well-being.
Sustentabilidade Ambiental em Unidades de Alimentação e Nutrição de um hospital do Rio de Janeiro
Authors: Chagas Regina Moura , Falcão Roberto Pessoa de Queiroz
Published: December 2022

O objetivo principal do estudo foi o de acompanhar a implementação da certificação Green Kitchen em uma unidade de alimentação e nutrição (UAN) hospitalar, visando observar as facilidades e as dificuldades de sua implantação, sabendo-se que ela está inserida em um hospital geral que passou por um processo de terceirização durante a pesquisa. Já os objetivos específicos do trabalho foram dois: (i) acompanhar a UAN de acordo com a implementação dos indicadores de desperdício de alimentos e recursos da empresa Green Kitchen; (ii) conhecer as expectativas e os objetivos futuros do gestor de hotelaria sobre sustentabilidade ambiental, identificando o conhecimento dos funcionários também em relação à sustentabilidade ambiental. Foi adotada a metodologia de estudo de caso da UAN, incluindo o levantamento de dados quantitativos e qualitativos durante a certificação, complementado pela observação direta, entrevista realizada com gestor de hotelaria e um questionário semiestruturado realizado com os funcionários. Dado que a unidade iniciou o processo e obteve a certificação pela Green Kitchen, percebeu-se que a gestão ambiental já estava presente no ambiente do hospital, sendo que os funcionários se encontravam incomodados com práticas que pudessem gerar a degradação do meio ambiente, embora possuíssem pouco conhecimento sobre a temática. Contudo, percebeu-se uma necessidade de reforçar os treinamentos sobre o tema. A entrevista com o gestor de hotelaria, indicou também que haveria uma preocupação maior com a captação de água da chuva e a produção de resíduos oriundos da alimentação na UAN hospitalar.
Relações de hospitalidade entre anfitriões e viajantes em busca de tratamento de saúde: o papel das casas de apoio
Authors: Sousa Eriberto Do Nascimento , Ribeiro Ruan Tavares , Alves Cristianelia Costa
Published: December 2022

Casas de apoio são unidades residenciais que acolhem viajantes em busca de tratamento de saúde, sobretudo em cidades referências em bens e serviços de saúde. O público-alvo desses espaços de acolhimento costuma ser pessoas que não dispõem de meios para se manter fora de seu entorno habitual. Apesar de os estudos da hospitalidade potencialmente contribuírem com a gestão desses espaços com vistas a um acolhimento humanizado aos hóspedes, pesquisadores do turismo e da hospitalidade pouco têm explorado esse objeto de estudo. Outras áreas do saber, por sua vez, têm se dedicado mais ao estudo das casas de apoio com ênfase na qualidade de vida e experiência dos pacientes e acompanhantes. Neste artigo, analisam-se as contribuições teóricas da hospitalidade sobre as relações entre anfitriões de casas de apoio e seus hóspedes por meio das práticas culturais de recepcionar, hospedar, alimentar e entreter. Por meio de uma pesquisa qualitativa em casas de apoio, em São Luís, Maranhão, constatou-se que as casas de apoio são espaços formados por anfitriões que demonstram a virtude da hospitabilidade em todos os tempos da hospitalidade. Isto é, reconhecem que o bem-estar de seus hóspedes também pode estar associado a todos os momentos da estada na casa de apoio. Outra constatação relevante, que fica como reflexão para formadores de políticas públicas, é percepção dos anfitriões sobre a relevância do entretenimento para os hóspedes; até mesmo quem ainda não oferece esse serviço reconhece sua importância, por isso articulam-se em busca de parceiros para tal.
Entrevista com Wallace Soares
Authors: Soares Wallace
Published: December 2022

Além dos artigos, a edição de dezembro da RAOIT conta com uma entrevista sobre saúde mental e turismo com o turismólogo Wallace Soares, fundador do Projeto Desbravando as Américas e, palestrante e membro associado do Copenhagen Institute For Futures Studies LATAM - CIFS LATAM. Wallace Soares é escritor, com dois livros publicados, palestrante, pesquisador e membro associado do Copenhagen Institute For Futures Studies. Ele possui formação acadêmica em Turismo e Hotelaria pela Universidade Estácio de Sá e Pós-Graduação em Diversidades e Inclusão Social em Direitos Humanos pela USP. O Desbravando as Américas trata-se de um projeto de viagem, idealizado pelo turismólogo carioca, Wallace Soares, morador da Comunidade do Turano, no bairro da Tijuca, que teve início no ano de 2014, com a missão de realizar uma road trip, de ônibus, por todos os países do Continente Americano. O Projeto tem como objetivo conhecer as riquezas culturais, históricas, gastronômicas e naturais presentes no Continente Americano através do ponto de vista dos moradores locais e de forma econômica. Através das suas experiências vivenciadas, Wallace consegue provar que com o planejamento correto as pessoas conseguem realizar grandes viagens durante o período de férias do emprego, fortalecendo o Turismo Inclusivo Socioeconômico, através da quebra de tabus historicamente enraizados na sociedade, além de chamar a atenção para o importante papel das viagens para o equilíbrio da Saúde Mental.
YOUTH SLANG AS A LINGUISTIC AND TRANSLATION PHENOMENON (on the material of modern Spanish)
Authors:   Kyiv National Linguistic University, Bokova Polina
Published: December 2022

The article deals with the youth jargon and sets out a few ways in its extensional usage is assimilated by the youth slang. The article tells about certain aspects of historical development of social dialect. An interrogation helps to understand the place of slang in the life of young people. The main source of the youth slang and certain particularities of its development are given. The mass use of slang vocabulary in all segments of the population is described - regardless of social or professional affiliation, age, communicative characteristics of use – whether public speaking, business communication or informal environment. Slang is such a common phenomenon, a linguistic phenomenon, that the phrase "modern jargon" is associated with speakers with it. Jargon is understood as a social kind of speech, which is characterized, in contrast to the vernacular, by specific expressively reinterpreted vocabulary and phraseology, as well as the special use of word-formation tools. Jargon belongs to relatively open social and professional groups of people united by common interests and functions as a nominative-expressive unit of speech, sometimes with a vulgar-familiar color. Quite often jargons are created on the basis of borrowings from different languages, polysemy, derivation, suffixes, etc. In addition, the article also states that the main supplier and language center of slang are elements of territorial dialects.
On Hyperideals of Multiplicative Hyperrings
Authors: COŞGUN Betül , ACAR Ummahan Merdinaz
Published: December 2022

Let R be a commutative multiplicative hyperring. In this paper, we introduce and study the concepts of n-hyperideal and δ-n-hyperideal of R which are generalization of n-ideals and δ-n-ideals of the in a commutative ring. An element a is called a nilpotent element of R if there exists a positive integer n such that 0∈a^n. A hyperideal I (I ≠R) of R is called an n- hyperideal of R if for all a,b∈R, a*b⊆I and a is non-nilpotent element implies that b∈I [15]. Also, I is called a δ-n-hyperideal if for all a,b∈R, a*b⊆I then either a is nilpotent or b∈δ(I) , where δ is an expansion function over the set of all hyperideals of a multiplicative hyperring. In addition, we give the definition of zd-hyperideal. Some properties of n-hyperideals, δ-n-hyperideals and zd-hyperideals of the hyperring R are presented. Finally, the relations between these notions are investigated.
Some Identities with Special Numbers
Authors: ÖMÜR Neşe , SÜDEMEN Kübra Nur , KOPARAL Sibel
Published: December 2022

In this paper, we derive new identities which are related to some special numbers and generalized harmonic numbers H_n (α) by using the argument of the generating function given in [3] and comparing the coefficients of the generating functions. Also considering q -numbers involving q -Changhee numbers Chnq and q-Daehee numbers Dnq, some sums are given. For example, for any positive integer n and any positive real number q > 1, whenα= q/(q-1), we have the relationship between generalized harmonic numbers and q -Daehee numbers
Production cross-section and reaction yield of 82Sr for 82Sr/82Rb generator
Authors: ŞENTÜRK Şevki , BAYRAM Tuncay , AKKOYUN Serkan
Published: December 2022

There are many radioisotopes used for diagnostic and therapeutic purposes in nuclear medicine. One of the radioisotopes used for diagnostic purposes is 82Rb. It is used in positron emission tomography (PET) as to be positron emitter and commonly obtained from 82Sr/82Rb generator. In this study, we have investigated some possible production mechanisms of 82Sr by regarding 82Sr/82Rb generator. 85,87Rb(p,xn)82Sr and 80,82,83,84,86Kr(3He,xn)82Sr reaction channels have been investigated using the CTFGM, BSFGM, and GSM models within the framework of TALYS nuclear reaction code. It has been seen that the production cross-sections, reaction yields and total activation values calculated up to 60 MeV beam energy value are in agreement with the available data in the literature.
Fixed Point Theorems In 2-Banach Spaces For Non-expansive Type Conditions
Authors: PAUL Mithun , SARKAR Krishnadhan , TİWARY Kalishankar
Published: December 2022

Fixed point theorems had been established and developed under various non-expansive type conditions on different metric spaces. In this paper, we have generalized (ψ,φ) - weak contractions, which is the generalizations of F-contraction, (ϕ,F)-contraction as well as (ψ,φ)-contractions. Then we have established some unique common fixed point results for a sequence of mappings for (ψ,φ)- weak contractions in 2-Banach spaces. Some basic definitions, properties and examples are given in the introduction and preliminaries part. Some corollaries are also given on the basis on the results.
Decolourization of Methylene Blue in Aqueous Solution by Photocatalytic Oxidation, Fenton Oxidation and Biosorption
Authors: KARTAL TEMEL Nuket , BAĞDA Esra
Published: December 2022

The aim of the study was to investigate decolourization of Methylene Blue (MB) in aqueous solution using advanced oxidation processes (AOPs) and biosorption comparatively. Photocatalytic decolourization of MB was studied using TiO2 as catalyst. The photocatalytic decolourization of MB by direct UV irradiation alone, only TiO2 and TiO2/UV processes was investigated. It was found that decolourization by photocatalytic process of MB increased with decreasing pH, and decolourization rate also increased in the presence of TiO2/UV when compared to UV irradiation alone. Decolourization of MB was also studied with using the Fenton process (Fe(II)/H2O2). Concentrations of Fe(II) and H2O2 on decolourization ratio were investigated. The optimum catalyst to H2O2 ratio was found 1:3 at pH 4.0. In the second part of the study, the biosorption process was conducted with using plant gall immobilised alumina. The removal percentages were calculated with both plant gall immobilised alumina and alumina alone. The immobilisation of plant gall increased the removal percentages from 60-70% to 90-95%. The proposed methods (AOPs and biosorption) have both advantages and disadvantages compared to each other.
Exactness of Proximal Group Homomorphisms
Authors: ÖZTÜRK Mehmet Ali
Published: December 2022

This research introduces groups in proximity spaces which endowed with a proximity relation. Two penultimate choices for such relations are the Efremovic (EF) proximity relation and its extension, namely, the descriptive EF-proximity relation. There is a strong relationship between sets (groups) and set (group) descriptions. Therefore, in this paper we consider this relationship via exactness of descriptive homomorphisms between ordinary descriptive groups and meta-descriptive groups. The definition of a short exact sequence of descriptive homomorphisms is given. Then, results were obtained giving the relationships between the two short exact sequences.
Acetylcholinesterase Inhibitor Activity of Some 5-Nitrothiophene-Thiazole Derivatives
Authors: NUHA Demokrat , EVREN Asaf Evrim , ÇİYANCI Zennure Şevval , TEMEL Halide Edip , AKALIN ÇİFTÇİ Gülşen , YURTTAŞ Leyla
Published: December 2022

The potential anticholinesterase characteristics of some thiazole derivatives (2a–2j), including the 5-nitrothiophene moiety, were examined in this work. 1H-NMR, 13C-NMR, and HRMS spectral data were used to determine the structure of the compounds. Using a modified Ellman's spectrophotometric approach, each compound was tested for its ability to inhibit acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) enzymes. It was determined that the compounds exhibited inhibition of between 33.66–47.96 % against AChE and 13.03–63.29 % against BuChE at 80 µg/mL concentration.
Design and Synthesis of Imidazole Derivatives as Anticancer Agents and Potential Aromatase Inhibitors
Authors: BOSTANCI Hayrani Eren , ACAR ÇEVİK Ulviye
Published: December 2022

In this study, imidazole derivative compounds were synthesized using the Debus-Radziszewski method. The chemical structures of the compounds were characterized by spectroscopic methods. The effects of target compounds on MCF7 (CRL-3435) were examined and their IC50 values and percent viability were calculated. In addition, the cytotoxic effects on the L929 (CCL-1) normal cell line were evaluated in order to determine the selectivities of the compounds. Then, the inhibition values of aromatase enzyme of the compounds were calculated and compared to the reference compound. When the results were examined, it was observed that Compound la caused the death of breast cancer cells, although not as much as cisplatin, but did not harm healthy cells. In this respect, it was determined that compound Ia has a promising anticancer effect as an aromatase inhibitor.
The Effects of Lapatinib and Trastuzumab in a Rat Model of Endometriosis
Authors: YILDIZ Çağlar , ÖZSOY Zeki , KACAN Turgut , ÖZER Hatice
Published: December 2022

Trastuzumab and lapatinib are drugs belonging to tyrosine kinase inhibitors family that are used in cancer treatment to prevent cell proliferation. Trastuzumab is an inhibitor of human epidermal growth factor receptor–2 (HER2) tyrosine kinase, and lapatinib is an inhibitor of epidermal growth factor receptor (EGFR). Tyrosine kinase inhibitors have also been investigated for treatment of endometriosis. In the present study, we aimed to investigate the effects of lapatinib and trastuzumab on rat endometriosis model. Endometriosis was surgically induced by the autologous transplantation of endometrial tissue and formation of endometriosis was confirmed via secondary laparotomy in 32 rats. Initially, 4 mg/kg dose of trastuzumab was applied intraperitoneally, and two additional doses of 2 mg/kg were applied 7 days and 14 days after the initial dose. Lapatinib was administered as 100 mg/kg daily doses for 14 days. Rats were randomly divided into four groups and were subjected to lapatinib, trastuzumab, anastrozole (0.004 mg/day, p.o.) and normal saline (0.1 ml, i.p.) treatments for 14 days. Then, endometriosis foci were excised, and endometriosis scores were calculated in a semi-quantitative manner. Immunohistochemical (IHC) examinations were also performed using VEGF, CD117 and Bax antibodies. Both anastrozole and tyrosine kinase inhibitors lowered endometriosis scores. Significant decreases in ovarian follicle numbers were observed in lapatinib and anastrozole groups but not trastuzumab group. Lapatinib and trastuzumab decreased endometriotic foci through suppressing cell proliferation and promoting programmed cell death.
Synthesis and Characterization of Novel Calix[4]arene Schiff Base Derivatives and Cytotoxicity Effect Evaluation on Cancer Cell Lines
Authors: IŞIK Ayşen , UÇAR ÇİFÇİ Kezban , BOSTANCI Hayrani Eren , TUTAR Yusuf , KOÇAK Ahmet , YILMAZ Mustafa
Published: December 2022

In this study, four stages were used to create brand-new p-tert-butyl-calix [4] arene Schiff base derivatives. First, p-tert-butyl-phenol and formaldehyde are reacted to create p-tert-butyl-calix [4] arene (1). In the following step, methyl bromoacetate and p-ter-butyl-calix [4] arene (1) were combined with acetone and reflux to create the p-tert-butyl-calix [4] arene diester complex (2). The third step involves reacting the diester compound (2) and hydrazine hydrate to create the p-tert-butyl-calix [4] arene hydrazinamide molecule (3). In the final stage, calix [4] arene Schiff base derivatives (4a-d) were produced in good yields by combining compound (3), p-tert-butyl-calix [4] arene hydrazinamide, and various aldehyde derivatives with reflux in EtOH. Through the use of 1H-NMR, 13C-NMR, infrared spectroscopy, and elemental analysis, the structures of produced compounds were verified. Four distinct cancer lines are linked to the antitumor activity of synthetic chemicals. (HT-29, a human colon cancer cell line, PC-3, a human prostate cancer cell line, C6, a rat glioma cell line and MCF-7, a human breast cancer cell line). Weak antitumor activity was seen in synthetic substances. However, only compound 4b was found to have potential efficacy against C6 and HT-29. It is clear that compound 4b, which has a nitro substitute on the phenyl ring, draws attention due to its increased activity.
History of the Kazan School of Dermatovenereology
Authors: Faizullina Elena V. , Fedorova Nataliya A. , Khismatulina Irina M. , Shamov Bulat  A. , Gusarova Ekaterina  S.
Published: December 2022

The Department of Skin and Venereal Diseases is one of the oldest departments of Kazan State Medical University. It originates in the bowels of the medical faculty of the Kazan Imperial University. The founder and first head of the Department of Skin and Syphilitic Diseases was Professor A.G. Ge. There are three periods in the development of the scientific school, which differ in research issues and teaching methods. The first period from the birth of the school of A.G. Ge until the end of the 1920s, it is characterized by the fight against syphilis, which is reflected in the name of the department of skin and syphilitic diseases. The starting point of the second period in the history of the Kazan school of Dermatovenereology can be considered 1930, when the medical faculty of the university formed an independent institute the Kazan State Medical Institute. At this stage, it is difficult to identify the main scientific direction, the research was carried out based on the urgent tasks of the time. The third stage (from the 1970s to the present) is characterized by research into issues of allergy and its skin manifestations. Employees of the Department of Dermatovenerology of the Kazan State Medical University are currently continuing the main traditions of the Kazan dermatovenerological school.
Comparative analysis of the associations between solar activity and trends in the incidence of haemoblastoses in Russia, the USA and Canada
Authors: Pinaev Sergey K. , Chizhov Alexey Ya. , Grjibovski Andrej M. , Pinaeva Olga G.
Published: December 2022

Background. Identification of the links between hemoblastoses and environmental factors is necessary for the development of preventive measures.
Aim. Comparative analysis of the link between hemoblastosis trends in Russia, the USA and Canada and solar activity.
Material and methods. The open data on the incidence of hemoblastoses in Canada (19832012), the USA (19982012) and Russia (19932018) was used. To estimate solar activity, the average annual number of sunspots (Wolff numbers) was taken. The relationship between the frequency of hemoblastoses and solar activity was studied using the Pearson correlation analysis in 11 iterations (lag 010 years). The results obtained are compared with the data of an earlier study on Russia.
Results. In Canada, an association with Wolf numbers was found in the frequency of Hodgkin's lymphoma in men (r=0.431, p=0.017, lag 2 years), multiple myeloma in women (r=0.542, p=0.037, lag 1 year), non-Hodgkin's lymphomas in men (r =0.538, p=0.038, lag 5 years) and women (r=0.750, p=0.001, lag 5 years), leukemia in men (r=0.707, p=0022, lag 7 years) and women (r=0.817, p=0.004, lag 7 years). In the United States, a relationship with solar activity was established for fluctuations in the incidence of Hodgkin's lymphoma in men (r=0.577, p=0.050, lag 5 years) and women (r=0.641, p=0.025, lag 5 years), non-Hodgkin's lymphomas in men (r=0.809, p 0.001, lag 3 years) and women (r=0.844, p 0.001, lag 2 years), leukemia in men (r=0.619, p=0.032, lag 1 year). In the Russian population, a relationship between solar activity and the frequency of all forms of hemoblastoses, was previously revealed. Fluctuations in the frequency of leukemia and non-Hodgkin's lymphomas in the populations of Russia, the USA and Canada have a strong positive relationship with solar activity. The strength of this association in Hodgkin's lymphoma and multiple myeloma ranges from moderate to significant. In all the countries studied, an increase in the incidence of multiple myeloma and leukemia was found, and an increase in the incidence of non-Hodgkin's lymphomas was found in Russia and Canada. The trend in the incidence of Hodgkin's lymphoma in Russia and Canada has a significant downward trend.
Conclusion. Trends in hemoblastoses in Russia, the USA and Canada are strongly related to solar activity.
The content of cytokines in the blood of patients with various stages of breast cancer
Authors: Saptarova Liliyana M. , Imelbaeva Elvira A. , Tukhbatova Aliya V. , Galimov Shamil N. , Mufazalova Natalia A.
Published: December 2022

Background. Cytokine homeostasis is an important factor characterizing the general condition and adaptive capabilities of the body of patients with malignant neoplasms. However, the role of various growth factors and their significance in the development and enhancement of malignant growth in breast cancer remain poorly understood.
Aim. To evaluate the levels of cytokines - tumor necrosis factor , interleukins-4, -6, -8 and -10 in the blood serum of patients with different stages of breast cancer in comparison with healthy volunteers.
Material and methods. The study was conducted in 65 patients aged 25 to 67 years (mean age 44.5 [40.056.5] years). Two groups were distinguished: the first with stage 12, the second with stage 34 of breast cancer. The comparison group consisted of 15 apparently healthy women without cancer, aged 29 to 66 years (mean age 51.0 [39.061.0] years). Blood levels of tumor necrosis factor , interleukins-4, -6, -8 and -10 were studied by enzyme immunoassay. The obtained data were processed using the methods of variation statistics, the Statistica 10.0 software package. The significance of differences was assessed by calculating the median and interquartile interval, analysis of variance was performed using the KruskalWallis H-test, and Dan's Q-test was used for multiple comparisons. The critical significance level p for statistical tests was taken equal to 0.05.
Results. In the group of patients with stage 12 breast cancer, an increase in the blood levels of all studied cytokines was revealed in comparison with the group of healthy women: interleukin-6 (p=0.00719), interleukin-8 (p=0.00259), tumor necrosis factor (p=0.00014), interleukin-4 (p1=0.0133), interleukin-10 (p1 0.00001). In the group of patients with stage 34 breast cancer, an increase in blood levels was characteristic of all studied cytokines: interleukin-8 (p=0.00009), tumor necrosis factor (p=0.000004), interleukin-4 (p 0.00001), interleukin-10 (p 0.00001), except for interleukin-6 (p=0.15608). The established patterns in changes in the content of cytokines in the blood of patients with breast cancer at different stages of development can serve as the basis for developing approaches to the diagnosis and treatment of the disease.
Conclusion. In patients with breast cancer, the levels of tumor necrosis factor , interleukins-4, -6, -8, -10 (p 0.05) are higher than in healthy women.
Comparative assessment of the quality of life and the effectiveness of treatment in patients after early and delayed anterior cruciate ligament reconstruction
Authors: Radysh Ivan I.
Published: December 2022

Background. In modern medical practice, a significant interest in the study of quality of life is manifested in the biopsychosocial approach, which indicates the concept of a holistic view of the course of the disease and the effectiveness of treatment.
Aim. To give a comparative assessment of the quality of life and the effectiveness of treatment of patients after early and delayed reconstruction of an isolated injury of the anterior cruciate ligament.
Material and methods. The results of a survey of 782 patients aged 1854 years according to the international standardized questionnaire of the quality of life (SF-36 Short Form-36 Health Survey Questionnaire) before and after arthroscopic reconstruction of an isolated injury of the anterior cruciate ligament using a free autograft from the tendons of the semitendinosus and tender muscles are presented. All patients were divided into two groups. The first group included 403 patients (232 males and 171 females), anterior cruciate ligament plasty was performed at an early stage, from the 1st to the 6th week after the injury. The second group included 379 patients (211 males and 168 females) who were operated on late, from the 7th week to 1 year after the injury. Statistical analysis was performed using the Statistica 12.0 program (Stat Soft, Inc.). The significance of differences between independent samples was determined using nonparametric tests: the MannWhitney U test and the Wilcoxon T test.
Results. It was found that 1 year after the operation, in patients of the first group, the values of the treatment effectiveness indicator in terms of the total indicator of physical and mental components of health are significantly higher compared to the second group (p 0.0001, MannWhitney U-test). A high correlation between the indicators of treatment effectiveness according to the assessment scales of the physical component of health and the mental component of health in groups depending on the timing of the reconstruction of the anterior cruciate ligament was found. Thus, the Spearman's rank correlation coefficient in the first group between the indicators of treatment effectiveness in terms of the total indicator of the physical and mental components of health was r=0.79 (p=0.001), and in the second group r=0.71 (p=0.001).
Conclusion. The long-term results of assessing the quality of life of patients indicate the predominant effectiveness of the treatment of patients operated on in the early stages after injury, compared with delayed surgery.
Possibilities of the Health Utilities Index questionnaire in assessing the quality of life of children with disabilities
Authors: Vinyarskaya Irina V. , Terletskaya Rimma N. , Chernikov Vladislav V. , Antonova Elena V , Fisenko Andrey P.
Published: December 2022

Background. Currently, in the Russian Federation, the criteria for establishing disability do not take into account the assessment of the quality of life, while in developed countries this indicator is a mandatory component of examination programs and evaluation of the effectiveness of treatment and rehabilitation. In Russian pediatrics, research on the development of indicators of the quality of life in children with chronic disabling diseases has begun, this work is a continuation of this direction.
Aim. To assess the quality of life of disabled children with various somatic diseases using all the possibilities of the Health Utilities Index questionnaire.
Material and methods. A survey of 213 patients aged 5 to 18 years with chronic diseases with the status of a disabled child and their legal representatives was conducted using the Russian version of the international general questionnaire Health Utilities Index. Statistical analysis was performed using the SPSS software package version 26.0. The KruskalWallis test and Dunn's posterior test were used.
Results. During the study, multi-attribute utilitarian indices were developed for each group of children, which ranged from 0.670.3 (95% confidence interval 0.550.78) in patients with rheumatological diseases to 0.850.21 (95% confidence interval 0.790.91) in children with heart disease and statistically significantly (p 0.001) were lower than in healthy children (0.90.17; 95% confidence interval 0.870.92). The features of one-attribute utilitarian indices depending on the class of the disease have been established. An analysis of the level and degree of functioning disorders showed that the most common and frequent for children with disabilities in the studied groups were emotional disorders; problems associated with the presence of pain; disability caused by a sense of cognitive deficit. For the first time, to determine the categories of the severity of violations an approach according to a multi-attribute utilitarian index was used.
Conclusion. The quality of life in children with disabilities, reduced compared to healthy peers, has nosological features; the most pronounced decrease in the quality of life was noted in children with skin diseases and rheumatological diseases.