bluuebunny/crossref_metadata_2025 huggingface dataset:
Synthesis of Fluorescent Carbon Nanoparticles by Dispersion Polymerization of Acetylene
Authors: Jayswal Vijay K. , Ritcey Anna M. , Morin Jean-Francois
Published: August 2022

Carbon nanoparticles (CNPs) have emerged as one of the most promising nanomaterials due to their distinct optoelectronic properties for a diverse range of applications in the area of electronics, energy conversion and storage, and bio-imaging. Their functions and properties can be changed by varying their shape, size and dimensionality. The synthetic methods reported until now involve high-temperature (>100 °C) processes, which often result in uncontrolled shape, size and polydispersity. In this work, we focus on the development of a low-temperature synthetic method for the preparation of fluorescent carbon nanoparticles and modulation of properties. Our method, based on the dispersion Glaser-Hay polymerization of acetylene followed by decomposition into a carbonaceous material, yields CNPs with sizes varying from 30 nm to 60 nm. The shape and size of the resulting carbon nanoparticles are influenced by changing different reaction parameters such as temperature, reaction time and pressure. The control over the different reaction parameters allows us to obtain monodisperse CNPs in spherical shapes. After isolation, CNPs were characterized by microscopy and spectroscopy techniques. The residual alkynes in the CNPs’ structure were exploited for further post-functionalization/ graphitization to yield multifunctional CNPs, which were fluorescent in the blue region.
Dual-Pathway Polyolefin Upcycling over an Unexpectedly Bifunctional Low-Loading Ru/TiO2-Anatase Catalyst
Authors: Chen Linxiao , Moreira Julia D. , Meyer Laura C. , Gutierrez Oliver Y. , Szanyi Janos
Published: August 2022

The large-scale production of non-degradable plastic waste calls for effective catalytic upcycling processes. In this work, we discovered that an anatase TiO2 synthesized by a sol-gel method (TiO2-A-SG) exhibits drastically better activity and selectivity as the support for low-loading Ru than other oxides in polypropylene (PP) upcycling under H2. Detailed analysis and control experiments with Ni and Pt revealed that this is because Ru/TiO2-A-SG also catalyzes hydrocracking besides hydrogenolysis. In addition to favoring high-valued liquid products, this increases branched alkane fraction from low-density polyethylene (LDPE), and allows efficient PP upcycling without noble metals. The unexpected Brønsted acidity of TiO2-A-SG is linked to the carboxylate layers TiO2 surfaces adsorb from air. Kinetic studies revealed that under testing conditions, the two pathways compete for dehydrogenated intermediates on metal surfaces, with low hydrogen pressure (PH2) and high branching level of the substrate favoring hydrocracking. Hydrogenolysis is the main pathway at PH2 = 30 bar for all tested substrates less branched than PP, in which the cleavage of 2C−2C bonds is strongly favored over that of 3C−xC bonds. This work reveals and compares the two co-occurring polyolefin upcycling pathways on a metal-acid bifunctional catalyst, offers insights to the complex reaction network, and how it is affected by catalysts and conditions. In addition, it uncovers a new type of Brønsted acid sites on TiO2 with deep implications in the broader scope of acid catalysis.
Molecular insights into high-altitude adaption and acclimatisation ofAporrectodea caliginosa
Authors: Perry Iain , Hernadi Szabolcs Balazs , Cunha Luis , Short Stephen , Marchbank Angela , Spurgeon David J , Orozco-terWengel Pablo , Kille Peter
Published: August 2022

Here, we explore the high-altitude adaptions and acclimatisation ofAporrectodea caliginosa. Population diversity is assessed through mitochondrial barcoding, identifying closely related populations across the island of Pico (Azores). We present the first megabase N50 assembly size (1.2 Mbp) genome forA. caliginosa. High- and low-altitude populations were exposed experimentally to a range of oxygen and temperature conditions, simulating altitudinal conditions, and the transcriptomic responses explored. SNP densities are assessed to identify signatures of selective pressure and their link to differentially expressed genes. The high-altitudeA. caliginosapopulation had lower differential expression and fewer co-expressed genes between conditions, indicating a more condition-refined epigenetic response. Genes identified as under adaptive pressure through Fstand nucleotide diversity in the high-altitude population clustered around the differentially expressed an upstream environmental response control gene, HMGB1. The high-altitude population ofA. caliginosaindicated adaption and acclimatisation to high-altitude conditions and suggested resilience to extreme weather events.This mechanisticunderstanding could help offer a strategy in further identifying other species capable of maintaining soil fertility in extreme environments.
MANAGERIAL ECONOMICS
Authors: Sudheer Dr Thummala
Published: August 2022

The basic purpose of this book is to assist readers to develop a thorough understanding of the various financial concepts, principles, techniques and important theories of Managerial Economics in a systematic way. Although there are a good number of standard books on “Managerial Economics”, there are differences in the adoption of the best methods of applying these principles
Study of the Mechanical Properties of Shell of Fuel Elements from Zr1% Nb Alloys at Radial Stresses Similar to Reactor Conditions
Authors: Savchenko V.I. , Belash N.N. , Krainyuk Yevgeniy A. , Voyevodin Viktor N.
Published: August 2022

When determining the mechanical properties of ring specimens, a feature of a uniaxial (standard) loading scheme is that the method of applying a load to a specimen is somewhat remote from that to which the pipe walls can be subject in real operating conditions, in particular, these are tubes of fuel element shells. As an alternative loading method, the method of strain of an ring specimen on a cylindrical rod was considered and tested. By compressing the cylindrical rod from the ends, which in this case expanded and exerted pressure on the inner walls of the ring specimen in the radial direction, the specimen was deformed. The plasticity of fuel element shells made of Zr-1%Nb alloy on ring specimens under different loading methods is evaluated: uniaxial tension on half-disk supports, on a cylindrical rod, and on a tapered rod. Uniaxial tensile strain was determined in accordance with the normative documentation for the test method. When testing on a tapered rod, a specimen with a thinned working part was used. For the proposed loading method, the radial strain was measured by the change in the sample diameter. The results of testing the samples on a cylindrical rod were compared with the previously obtained results on half-disc supports and a tapered rod. The method of deformation of a ring specimen on a cylindrical rod makes it possible to obtain higher values of plasticity in comparison with uniaxial tension. In addition, the proposed method of deformation of a sample on a cylindrical rod, in contrast to uniaxial tension, in terms of the nature of the stress state, approaches to the operating reactor conditions.
Formation of Optical Images with Synchrotron Radiation Flux of Relativistic Electrons in the X-Ray Generator "Nestor"
Authors: Mazmanishvili Aleksandr , Moskalets Nataliya
Published: August 2022

When setting up physical experiments involving the use of the polarization properties of synchrotron radiation (SR) or a monoenergetic photon beam, detailed calculation of the spectral angular distribution of SR and its polarization components is of interest. Consideration of the electron beam size shows that in real conditions the radiation propagating in the plane of the equilibrium orbit will not be completely polarized, and the shape and dimensions of the angular distribution of radiation will be distorted. The motion of electrons in the uniform magnetic field and SR of the beam of relativistic particles in the storage ring of "NESTOR" are considered. The effect of the size of the electron beam with the energy of E=225 MeV in the 6-dimensional space on the formation of images of the flux of quanta of SR is analyzed. It is shown that the main contribution to the formation of images is made by the two-dimensional distribution of particles along the vertical direction axis and vertical oscillations. A software simulation code has been developed, the use of which made it possible to simulate the process of optical image formations by the flux of SR quanta (Этого предложения нет в русской аннотации). The formation of images of the radiation of electrons with an energy of E=225 MeV with change in the longitudinal distance L to the registration plane is considered. It is determined that at small longitudinal distances the main contribution to the image is made by the vertical distribution of particles in the beam. With an increase in the basic distance L, the contribution of the distribution of particles over vertical oscillations increases, which becomes decisive for large L value. Numerical simulation of image formation has been carried out. For the base distance of 300 cm and beam parameters with the vertical root mean square size of 0.2 mm and a vertical root mean square size of 0.15 mrad, the family of angular distributions is presented in the form of two-dimensional histograms for wavelengths , , , where , is the critical wavelength of SR. The dimensions of the optical window are obtained, the size of which makes it possible to reliably register the entire flux of SR quanta for the indicated registration characteristics.
Clinical and immunological efficiency of different therapy schemes in patients with infectious mononucleosis caused by Epstein-Barr virus
Authors: Pavlikova Ksenia , Liadova Tetiana , Volobuieva Olha , Hamilovska Alla , Shepileva Natalia
Published: August 2022

Abstract. The study of the role of Epstein-Barr virus infection in the development of various human pathological conditions is of great importance. This is due to the significant epidemiological role and social significance, because according to epidemiological data, more than 90 % of people are infected with VEB when they reach adulthood. The steady increase in the number of diseases caused by VEB in both adults and children is associated with its specific susceptibility to immunocompetent cells, lifelong persistence and latent course, which necessitates a comprehensive study and development of effective treatments. The aim of this study was to evaluate the effectiveness of ribonucleic acid in the correction of immune disorders in patients with infectious mononucleosis caused by Epstein-Barr virus. Materials and methods: To achieve this goal, 110 patients with IM were examined, including 58 women (52.7 %), men – 52 (47.3 %). The mean age of patients was 23.3 ± 4.2 years. The material for the study was the serum of patients obtained in the dynamics of the disease. The complex of examination of patients with IM included clinical and biochemical methods, enzyme-linked immunosorbent assay, polymerase chain reaction method, immunogram. The results of the research were processed by the method of variation and correlation statistics using the program «Statistica 10.0 for Windows». The analysis of the obtained results allowed to establish that in patients with IM changes in the system of cellular and humoral parts of the immune system and the diversity of the immune response were detected. The progressive nature of changes in immune parameters indicates the formation of secondary cellular immune imbalance, activation of the humoral link, a change in the balance of immunoregulatory mediators towards Th2 cells. In the acute period, probable disorders of the cellular immune system, characterized by an increase in the number of cells with killer activity: mature T-lymphocytes (CD3+), cytotoxic T-suppressor cells (CD8+), cells expressing the activation marker CD25+ (receptor IL2) and increase Th1/Th2. Under the influence of complex immunomodulatory and antiviral action with the appointment of ribonucleic acid, there is a more positive dynamics of immunological parameters compared with patients who received only basic therapy, which is manifested by an increase in the proliferative response. Conclusions. For the correction of immune disorders in patients with IM, associated with VEB the use of complex therapy with the drug nuclex (ribonucleic acid) (250 mg) 2 capsules 3 times a day for 14 days and valaciclovir (500 mg) at a dose of 1000 mg (2 table) 3 times a day for 14 days.
X-ray vascular technologies. analysis of errors in the diagnostic and treatment algorithm of patients with mediastinum tumors
Authors: Kravchenko Roman , Avdosiev Yuriy
Published: August 2022

This article considers the unsolved problem of diagnostic and therapeutic approach to patients with mediastinal tumors. The aim of the study was to increase the efficacy of treatment of patients with mediastinal epithelial tumors by using intra-arterial chemoembolization as a neoadjuvant therapy to create ischemia and high concentrations of cytostatics in tumors over a long period of time to devitalize tumor tissue and reduce overall chemotherapy toxicity. Object of study. Epithelial tumors of the thymus gland. Research methods: Clinical, laboratory, morphological, instrumental, statistical. Laboratory tests will include general clinical blood tests, biochemical parameters (ALT, AST, bilirubin, alkaline phosphatase, gamma-glutamine transpeptidase, lactate dehydrogenase, albumin), biochemical markers of thymus tumor (AFP, HGT), acetyl. General blood test (hemoglobin, erythrocytes, leukocytes, platelets). Instrumental methods of examination will include CT (computed tomography) with intravenous contrast, MRI (magnetic resonance imaging). Conclusions can be drawn from the literature. It can be stated that there is no single point of view on the diagnosis and choice of treatment tactics for patients with epithelial tumors of the thymus. Histological heterogeneity of tumors of this anatomical region with the similarity of clinical manifestations and radiological symptoms requires the development of algorithms for their differential diagnosis and optimization of treatment. In addition, over the last decade in Ukraine there has been a significant increase in the number of mediastinal tumors, especially thymus. Given mainly the young age of patients with this disease and the high degree of aggressiveness of the disease, the problem is transformed at the social level. It is also necessary to reconsider the traditional approach to the treatment of this pathology, the first link of which is considered to be surgery.
PROMOTING STUDENTS’ SPEAKING SPONTANEOUS THROUGH ENGLISH SURVIVAL ACTIVITY: A CASE STUDY ON STUDENTS OF AGRICULTURE
Authors: Nurhidayat Eka , Syarifah Eva Fitriani
Published: August 2022

English lecturers frequently worry about encouraging students to use English in spontaneous conversation, mainly English, for specified purposes. The study details classroom activities that encourage students to talk spontaneously in Agriculture. An early stage of group preparation is required to instil confidence in students to speak English freely in class. Students are responsible for identifying themes and laying the framework for class discussions. Cultivation, food production, and cattle business are suggested materials for various class activities. The teacher's role is to enlighten students about available resources, establish ground rules, and promote free expression. These events are intended to instil students’ confidence in English speaking.
Nursing students’ innovation and creativity approaches: A descriptive study
Authors: Can Özdemir Rana , Işık Meryem Türkan
Published: August 2022

The aim of this study is to reveal the creativity and innovativeness attitudes of nursing students who receive vocational education, to determine the influencing factors and to increase their awareness of innovation and creativity in nursing. The research was conducted as a descriptive study. The sample consisted of 399 nursing students. To collect data “Personal Information Form”, “Individual Innovativeness Scale Adapted for Nursing”, “Individual Creativity Scale” were used. Descriptive values, Shapiro-Wilk, Chi-square, Student’s-t, ANOVA, Tukey, Pearson Correlation test were used in the evaluation of the data. Ethics committee and institutional permission were obtained for the study. The average age of the participants is 20.82 ±1.69. The total score average of the participants is 59.19 for the Individual Innovativeness Scale and 55.58 for the Individual Creativity Scale. A significant relationship was found between genders, the place lived in the longest, the need for innovative thinking and individual innovativeness total score average. Also, a significant relationship was found between gender, place lived in the longest, participation in scientific activities related to creativity and innovativeness and innovative thinking status and creativity scale average score. The participants were skeptical about individual innovativeness and their creativity score average was at a medium level. The creativity and innovation scale scores of the participants were affected by some sociodemographic characteristics. It is recommended to plan trainings to raise awareness about innovation and creativity.
Modelagem matemática para a infestação de mexilhões dourados no reservatório da hidroelétrica de Jupiá-SP
Authors: Barreto Barbosa Charles Henrique Xavier , Dias Claudia Mazza , Pastore Dayse Haime , Silva Jose Carlos Rubianes , Costa Anna Regina Corbo , Figueira Raquel Medeiros Andrade , Fortunato Humberto Freitas de Medeiros
Published: August 2022

A presença do invasor biológico conhecido como mexilhão dourado se apresenta como uma importante ameaça ao funcionamento de hidroelétricas por se acumular nas estruturas comprometendo seu funcionamento. Neste estudo, propomos um modelo matemático para a dinâmica de crescimento da espécie no reservatório de Jupiá-SP. Os resultados evidenciaram o processo de infestação a partir da saída do rio Tietê e avançando gradativamente pela região, atingindo áreas que merecem atenção. O estudo, portanto, tem potencial para colaborar com o planejamento de ações de controle da infestação na região.
Aplicação do método de limitadores de inclinação para leis de conservação - Equações de águas rasas
Authors: Paula Ana Caroline Da Silva , Vigo Daniel G. Alfaro
Published: August 2022

O presente trabalho apresenta um estudo aplicado a problemas modelados por leis de conserva\-ção, com condições iniciais e de contorno apropriadas. Em particular, abordaremos a aplicação de métodos limitadores com ênfase no método limitador de inclinação na solução das equações de águas rasas no caso linear e não linear. Apresentamos através de exemplos numéricos um estudo comparativo do comportamento de diferentes funções limitadoras.
Distribución natural de Taxodium huegelii C. Lawson en el estado de Hidalgo
Authors: Canales-Perez Rafael , Hernández-León Sergio , Palacios-Romero Abraham , Hernández Lazcano Adriana , Rodríguez-Laguna Rodrigo , Suárez-Islas Alfonso , González-Ávalos José , Arce-Cervantes Oscar
Published: August 2022

Taxodium huegelii (sinónimo: Taxodium mucronatum) es un árbol que habita en bosques de galería; sus nombres comunes son ahuehuete, árbol de Tule, ciprés de Montezuma o sabino. El objetivo de esta investigación fue generar mapas de distribución actual y potencial para la especie en el estado de Hidalgo. Para elaborarlos se emplearon 56 registros, obtenidos de colectas en campo y una búsqueda en bases de datos. Los registros se analizaron previamente para evitar errores de procedencia y datos repetidos. El mapa de distribución documentada se generó con ArcGIS® versión 10.3 y el mapa de distribución potencial mediante Maxent versión 3.4.1. Las provincias biogeográficas Altiplano Sur (Zacatecano-Potosino), Sierra Madre Oriental y el Golfo de México fueron las únicas que tuvieron registros de presencia, los cuales se localizaron en 23 de los 84 municipios de Hidalgo; sin embargo, de acuerdo con los resultados, existe 46 % de idoneidad para que la especie se distribuya en 63 municipios del estado. El modelo de distribución potencial es satisfactorio, ya que tiene una predicción de 92 %. La distribución de T. huegelii se favorece en zonas donde la temperatura mínima del mes más frío no es menor a 3 °C, y en lugares con un intervalo de precipitación de 100 a 500 mm. Los mapas de distribución real y potencial generados constituyen la base para futuras investigaciones sobre este taxon emblemático de México.
Study On Online Platform For Personal Exhibition In Metaverse Emvironment
Authors:   Korean Institute of Smart Media, Park Yu Mi , Shin Choon Sung
Published: August 2022

This proposes a direction to build and provide an exhibition space based on the metaverse platform so that artists can independently open their own exhibitions in an online environment. Although many artists are produced every year, offline exhibitions are becoming difficult due to not many art galleries, and offline exhibitions are becoming impossible due to Corona, which began at the end of 2019, and online exhibitions are emerging as an alternative. We analyze cases of existing online exhibition methods and visit online exhibition methods such as web, video, and virtual reality and metaverse environment then present a plan for individual exhibitions in consideration of the recent metaverse environment. The proposed metaverse-based personal exhibition method is structured so that artists can construct a space on the metaverse and place their works, and then viewers can freely take a look on it from a remote location. Based on the proposed exhibition direction, the representative metaverse platform was applied to confirm the characteristics and possibilities of exhibition space and composition of works and users' exhibition experience. In the face of the rise of online exhibitions, space can be constructed in the direction the artist pursues in online exhibitions as well as offline exhibitions, but also online exhibitions, and hopes that online exhibitions will become another genre of exhibitions rather than incidental after the end of Covid-19.
ADAPTATION OF PERSONAL REPUTATION SCALE INTO TURKISH: THE VALIDITY AND RELIABILITY STUDY
Authors: GÖK Benan
Published: August 2022

Bu araştırmanın amacı, Hochwarter, Ferris, James, Zinko ve Arnell (2007) tarafından geliştirilmiş olan kişisel itibar ölçeğini Türk dil ve kültürüne uyarlayarak geçerlik ve güvenirliğini incelemektir. Böylelikle kişisel itibar ölçeğinin ulusal literatüre kazandırılması amaçlanmaktadır. Bu ölçek, izleyicilerin birey hakkındaki bütünsel değerlendirmelerini ortaya koyan bir ölçüm aracıdır. Araştırmaya katılan 945 Fenerbahçe Spor Kulübü taraftarının yönetim kurulu başkanının itibarını değerlendirmeleri için anket uygulaması yapılmıştır. Kişisel itibar ölçeğinin Türkçe’ye çevrilmesi aşamasında çeviri-tekrar-çeviri tekniği uygulanmıştır. Elde edilen veriler ışığında ölçeğin yapı geçerliği, yakınsak geçerliliği ve güvenilirliği test edilmiştir. Yapılan analiz sonuçlarına göre, yönetim alanındaki araştırmalar için kişisel itibar ölçeği geçerli ve güvenilir bir ölçme aracı olduğu ve ulusal literatüründe kullanılabileceği görülmüştür.
EXAMINING THE ENVIRONMENTAL COMMITMENT OF EMPLOYEES: COMPARISON OF PUBLIC AND PRIVATE SECTOR
Authors: DEĞİRMENCİ Bekir
Published: August 2022

The study examined whether the environmental engagement of public and private sector employees differs according to demographic characteristics. The study, which used the quantitative research method, collected data from 386 employees. "t-test, anova test and correlation tests" were applied to the data set. As a result of the analysis, it was found that environmental commitment does not differ by gender. It was found that the environmental commitment of private sector employees is higher than that of public sector employees. It was found that the environmental commitment of the participants differs according to their marital status. When analyzing environmental commitment by education level, it was found that environmental commitment is highest among graduates of higher education and lowest among high school graduates. In addition, environmental commitment was found to be higher among public sector employees. It is strongly recommended that the study be applied to different cultures and different occupational groups with more sample groups to determine if environmental commitment differs by type of institution.
Considerations for Permitted Daily Exposure Calculation for Contaminants in Medicinal Products Manufactured in Shared Facilities
Authors: Solodovnikov A. G. , Morkovin E. I. , Kurkin D. V. , Sorokina E. Yu. , Peretolchina T. F.
Published: August 2022

The manufacture of different medicinal products in shared facilities creates a risk of cross-contamination. One of the approaches to select the limits for possible contaminants is based on calculating the permitted daily exposure (PDE), i.e. the dose of an active pharmaceutical ingredient or any other substance contaminating a medicinal product that will not be associated with any adverse events in a human in the case of lifetime exposure. The aim of this study was to provide practical guidance on selecting adjustment factors for calculating PDEs to establish limits for potential contaminants in multi-purpose pharmaceutical facilities. The authors analysed the regulatory requirements and literature needed to establish critical effects of contaminants, outlined possible assumptions in the use of quantitative indicators for measuring toxicity, and described the relationship between the PDE and other indicators of the safety of chemical compounds for human health. The article presents an example of PDE calculation for an investigational hypoglycemic medicinal product using a limited amount of open-source literature data. Thus, the article demonstrates the role of information on the primary pharmacodynamic effects of medicinal products in the assessment of their critical effects, which is necessary to implement the most conservative approaches to PDE calculation. The example of PDE calculation presented in the article may be used to assess cross-contamination risks associated with non-dedicated manufacturing facilities.
Experimental Investigation of the Effect of Nitromethane Addition to Gasoline Fuel on A Single-Cylinder Spark-Ignition Engine Performance and Emissions
Authors: ÇELEBİ Samet , DEMİR Üsame , ERGEN Gökhan
Published: August 2022

In this study, the effect of nitromethane addition to gasoline fuel on engine perfor-mance and emissions in a single-cylinder spark-ignition engine was experimentally inves-tigated. By adding 5% and 10% nitromethane to gasoline, experiments were carried out at full load at six different cycles. Engine load, fuel consumption, exhaust gas tempera-ture, and emissions were measured during the experiments. According to the measured experimental data, engine power, torque, specific fuel consumption, exhaust gas tem-perature, average effective pressure, thermal efficiency, CO, CO2, HC, and NOx values were compared with each other. According to these results, nitromethane's addition im-proved engine power, torque, specific fuel consumption, and thermal efficiency. It is un-derstood that the addition of nitromethane to gasoline improves combustion efficiency and increases thermal efficiency. With the addition of nitromethane, an increase in CO2 emission, which is a product of complete combustion, and a decrease in CO emission occurred. This supports the increase in combustion efficiency. HC emissions have de-creased. There has been an increase in NOx emissionsIn addition, since the addition of more than 10% nitromethane causes engine instability, it has created difficulties in using it without modification in the engine.
Persepsi Pendidik PAUD Terhadap Aplikasi EduGame MARU sebagai Alternatif Media Pembelajaran Jarak Jauh
Authors: Safitri Desi , Suzanti Lizza , Widjayatri Rr. Deni
Published: August 2022

Kendala dalam pembelajaran jarak jauh terkait ketersediaan media pembelajaran berbasis teknologi bagi anak usia dini dapat disiasati dengan membuat sebuah aplikasi pembelajaran sesuai dengan kebutuhan. Tujuan penelitian ini yaitu mengetahui persepsi pendidik anak usia dini terhadap Aplikasi EduGame MARU sebagai alternatif media pembelajaran jarak jauh. Pendekatan kuantitatif dengan metode survey digunakan dalam studi ini. Teknik pengumpulan data dengan penyebaran kuesioner melalui google form diisi oleh 35 pendidik anak usia dini dengan teknik purposive sampling. Hasil studi menunjukkan responden memiliki persepsi positif terhadap Aplikasi EduGame MARU karena menumbuhkan semangat saat belajar serta menyenangkan bagi anak dalam mengenal matematika permulaan. Aplikasi EduGame MARU pun efektif digunakan selama pembelajaran jarak jauh dan dapat memberikan umpan balik kepada pendidik untuk menyebarluaskan Aplikasi EduGame MARU kepada pendidik anak usia dini lainnya. Rekomendasi dalam penelitian ini adalah Aplikasi EduGame MARU hadir sebagai alternatif media penunjang dalam pembelajaran jarak jauh sehingga kendala yang dihadapi oleh pendidik dapat diatasi dengan optimal.
Application of multiple strategies to efficiently break seed dormancy of permanently odd pentaploid rose hip (Rosa canina l.) under in vitro conditions
Authors: HAJYZADEH Mortaza
Published: August 2022

Rosehip (Rosa canina L.) is an important medicinal, and ornamental plant species with high commercial value. Its sugars, phenolics, organic acids, water-soluble vitamins, and mineral contents composition varies depending on environmental conditions and genetics. The plant is also used as a perfect rootstock for many rose cultivars. Seed proliferation is extremely difficult because of multiple endogenous and exogenous dormancy factors. There is a need to breed standard rosehip cultivars rootstock developments with desired characteristics and outperforming yields in fields. The study aimed to break the seed dormancy of rosehip under in vitro conditions by application of multiple strategies in an efficient manner. The seeds were treated with different doses of GA₃, scarified mechanically, stratified on agar solidified MS medium containing GA₃ singly or in combinations of the two each or three treatments, and subjecting them to the regulated physiological treatment of alternating warm/chilling and cold/dark treatments in parallel for 21 d ensued by 18 d warm/light treatments. It was noted that the rosehip seeds could be germinated variably if the scarified seeds were stratified on agar solidified MS medium with or without GA3. Optimum seed germination (80.00- 85.00%) was noted when the three treatments were combined and the seeds were subjected to regulated and alternating warm and chilling treatments for 21 d leaving them for 18 d in warm/light. These results are very important and could be utilized in breeding and multiplication programs to develop new rosehip fruit and rootstock cultivars.
A Collection of Numerical Recipes Useful for Building Scalable Psychometric Applications
Authors: Doran Harold
Published: August 2022

This article is concerned with a subset of numerically stable and scalable algorithms useful to support computationally complex psychometric models in the era of machine learning and massive data. The subset selected here is a core set of numerical methods that should be familiar to computational psychometricians and considers whitening transforms for dealing with correlated data, computational concepts for linear models, multivariable integration, and optimization techniques.
SCIENTIFIC ACTIVITY OF TROTSKYI PETRO ANATOLIYOVYCH – THE MASTER OF AGRICULTURE (to the 55th anniversary of the birth)
Authors: Shcherbak O. V. , Kovtun S. I.
Published: August 2022

The purpose of the article is to highlight the scientific achievements of P. A. Trotskyi, the Master of Agriculture, the biotechnologist in the field of animal husbandry, and his contribution to the development of research in biotechnology, the preservation of the gene pool of agricultural animals. Research methods are general scientific (analysis, bibliographic), retrospective and source studies.

The scientific novelty of the article lies in the presentation of the results of P. A. Trotskyi's scientific works, which contribute to solving the problem of preserving animal husbandry resources and improving methods of long-term preservation of genetic material. Among them: the development of new biotechnological methods of cryopreservation of gametes of farm animals to implement the objectives of the methodology of the Bank of Animal Genetic Resources at the cellular level using embryological genetics methods; the use of deconserved oocytes for the rational use of the genetic potential of highly productive and breeding females and obtaining more offspring from them.

The researcher was directly involved in the development of methodological aspects of the preservation of the gene pool of farm animals, which include a description of the main stages of obtaining embryos of farm animals in vivo and in vitro, their quality assessment and cryopreservation procedures. One of the main ways of implementing industry-wide programs to preserve and maintain the diversity and specificity of gene pool objects is the functioning of the Bank of Animal Genetic Resources. Together with his colleagues, the scientist defined its role in programs of cryopreservation of genetic resources, described the main requirements for the physical structure of the bank, its tasks and functions in the system of preservation, reproduction and selection of agricultural animals.

The results of P. A. Trotskyi's scientific developments were taken into account in the preparation of "Methods of scientific research on breeding, genetics and biotechnology in animal husbandry" (2005) and "Program for the preservation of the gene pool of the main species of agricultural animals in Ukraine for the period until 2015" (2009). With the participation of the scientist, a cryocollection of 44 eggs of the Myrhorod breed was created in the Bank of Animal Genetic Resources, which is necessary for the accelerated recovery and preservation of local pig breeds of Ukraine. Based on the functioning of the Bank, the methodology of cryopreservation of genetic resources of agricultural animals will be implemented, including as "virtual gene pool cryoherds".
Genome Editing in Translational Medicine: An Inventory
Authors: Dobner Jochen , Ramachandran Haribaskar , Rossi Andrea
Published: August 2022

Genomic mutations are the driving force of biological diversity but they are also the cause of a plethora of human diseases ranging from heritable disorders to neurological pathologies and cancer. For most genetic disorders, there is no curative treatment available to date. The demand for precise, preferably patient-specific, treatment regimen offering cure is naturally high. Genome editing by Zinc Finger Nucleases (ZFNs), Transcription Activator-Like Effector Nucleases (TALENs), and Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas enables targeted manipulation of genomes, thereby offering the opportunity to treat such diseases. While ethical and regulatory guidelines need to be developed and considered, the prospect of genome editing for curative treatment is certainly exciting. Here, we review the current state of therapeutics based on genome editing techniques. We highlight recent breakthroughs, describe clinical trials employing genome editing-based medicine, discuss the benefits and pitfalls, and take a look into the future of genome editing.
Antioxidants Rich Herbal Formula Ger-Gen-Chyn-Lian-Tang Protects Lipotoxicity and Ameliorates Inflammation Signaling through Regulation of Mitochondrial Biogenesis and Mitophagy in Nonalcoholic Fatty Liver Disease Mice
Authors: Wang Cheng-Hui , Liu Hsuan-Miao , Chang Zi-Yu , Lee Ming‑Chung , Hsu Chung-Hua , Lee Tzung-Yan
Published: August 2022

Background: Non-alcoholic fatty liver disease (NAFLD) has become a prevalent issue and a consequence of metabolic syndrome impact on human health. Both of anti-atherosclerosis and anti-hepatic fibrosis capabilities of herbal medicine Ger-Gen-Chyn-Lian-Tang (GGCLT) has attracted attention, but their molecular regulatory mechanisms in a NAFLD model have not been elucidated. The aim of the present study was to explore the bioactivity of db/db mice following treatment with GGCLT. Methods: NAFLD phenotype of db/db mice were treated with GGCLT and lipogenesis, mitochondria dysfunction, mitophagy, macrophage polarization and adipose tissue browning were then evaluated using qRT-PCR and/or Western blot analysis, immunofluorescence, and immunohistochemistry assays, respectively. Results: GGCLT not only decreased serum levels of TG and free fatty acids, but glucose and insulin tolerance test in db/db mice. In parallel, GGCLT reduced lipogenesis and hypoxia-inflammation cascades in NAFLD progression. GGCLT reduced lipid accumulation and was accompanied by the enhanced mitochondria biogenesis, M2 macrophage, and decreased M1 macrophage. The latter two events contributing to the anti-inflammation are resulting from mitochondria dynamics, and the lipotoxicity lowering effect of GGCLT of NAFLD mice is mediated by promoting mitophagy in Parkin-dependent and -independent pathways, by mitochondrial fusion over fission manner. GGCLT also inactivated lipogenesis and decreased lipid accumulation in epididymal white adipose tissue with a higher M2/M1 macrophage ratio. Conclusions: Besides in the liver, modulating of mitochondrial biogenesis and adipose tissue browning were characterized by increased Tmem26, Tfam, and Prdm16 expression by GGCLT in EWAT also contributes to the beneficial action in NAFLD.
BDNF Alterations in Brain Areas and the Neurocircuitry Involved in the Antidepressant Effects of Ketamine in Animal Models, Suggest the Existence of a Primary Circuit of Depression
Authors: Carboni Ezio , Carta Anna R.
Published: August 2022

Major depressive disorder is one of the primary causes of disability and disease worldwide. The therapy of depression is prevalently based on monoamine reuptake blockers; consequently, investigations aimed to clarify the aetiology of depression have mostly looked at brain areas innervated by monamines and brain circuitry involved in inputs and outputs of these areas. The recent approval of esketamine as a rapid-acting antidepressant drug in treatment-resistant depression, has definitively projected glutamatergic transmission as a key constituent in the use of new drugs in antidepressant therapy. In this review we have examined the role of several brain areas: namely, the hippocampus, the medial Prefrontal Cortex (mPFC), the nucleus accumbens (NAc), the Lateral Habenula (LHb), the amygdala and the Bed Nucleus of Stria Terminalis (BNST). The reason for undertaking an in-depth review is due to their significant role in animal models of depression, which highlight their inter-connections as well as their inputs and outputs. In particular, we examined the modification of the expression and release of the brain derived neurotrophic factor (BDNF) and associated changes in dendritic density induced by chronic stress in the above areas of animal models of depression (AnMD). We also examined the effectiveness of ketamine and standard antidepressants in reversing these alterations, with the aim of identifying a brain circuit where pathological alteration might trigger the appearance of depression symptoms. Based on the role that these brain areas play in the generation of the symptoms of depression, we assumed that the mPFC, the NAc/Ventral Tegmental Area (VTA) and the hippocampus form a primary circuit of depression, where regular performance can endure resilience to stress. We have also examined how this circuit is affected by environmental challenges and how the activation of one or more areas, including amygdala, LHb or BNST can produce local detrimental effects that spread over specific circuits and generate depression symptoms. Furthermore, we also examined how, through their outputs, these three areas can negatively influence the NAc/VTA-PFC circuit directly or through the BNST, to generate anhedonia, one of the most devastating symptoms of depression.
The Challenges of Diagnosis and Treatment of Arrhythmogenic Cardiomyopathy: Are We there yet?
Authors: Spadotto Alberto , Morabito Domenico , Carecci Alessandro , Massaro Giulia , Statuto Giovanni , Angeletti Andrea , Graziosi Maddalena , Biagini Elena , Martignani Cristian , Ziacchi Matteo , Diemberger Igor , Biffi Mauro
Published: August 2022

Background: we sought to review the evolution in the diagnosis and treatment of Arrhythmogenic Cardiomyopathy (ACM), a clinically multifaceted entity beyond the observation of ventricular arrhythmias, and the outcome of therapies aiming at sudden death prevention in a single center experience. Methods: retrospective analysis of the data of consecutive patients with an implanted cardioverter-defibrillator (ICD) and a confirmed diagnosis of ACM according to the proposed Padua Criteria, who were referred to our center from January 1992 to October 2021. Results: we enrolled 72 patients (66% males, mean age at implant 46 ± 16 years), 63.9% implanted for primary prevention. At the time of ICD implant, 29 (40.3%) patients had a right ventricular involvement, 24 (33.3%) had a dominant LV involvement and 19 (26.4%) had a biventricular involvement. After a median follow-up of 6,1 years [IQR: 2.5–9.9], 34 patients (47.2%) had 919 sustained episodes of ventricular arrhythmias (VA). 27 patients (37.5%) had 314 episodes of life-threatening arrhythmias (LT-VA), defined as sustained ventricular tachycardia ≥200 beats/min. Considering only the patients with an ICD capable of delivering ATP, 80.4% of VA and 65% of LT-VA were successfully terminated with ATP. 16 (22.2%) patients had an inappropriate ICD activation, mostly caused by atrial fibrillation, while in 9 patients (12.5%) there was a complication needing reintervention (in 3 cases there was a loss of ventricular sensing dictating lead revision). During the follow-up 11 (15.3%) patients died, most of them due to heart failure, and 8 (11.1%) underwent heart transplantation. Conclusions: ACM is increasingly diagnosed owing to heightened suspicion at ECG examination and to improved imaging technology and availability, though the diagnostic workflow is particularly challenging in the earliest disease stages. ICD therapy is the cornerstone of sudden death prevention, albeit its efficacy is not based on controlled studies, and VT ablation/medical therapy are complementary to this strategy. The high burden of ATP-terminated VA makes shock-only devices debatable. The progressive nature of ACM leads to severe biventricular enlargement and refractory heart failure, which pose significant treatment issues when a predominant RV dysfunction occurs owing to the reduced possibility for mechanical circulatory assistance.
The Remaining Conundrum of the Role of the Na+/H+ Exchanger Isoform 1 (NHE1) in Cardiac Physiology and Pathology: Can It Be Rectified?
Authors: Karmazyn Morris , Pierce Grant N. , Fliegel Larry
Published: August 2022

The mammalian Na+/H+ exchanger (NHE) is a family of ubiquitous membrane proteins present in humans. Isoform one (NHE1) is present on the plasma membrane and regulates intracellular pH by removal of one intracellular proton in exchange for one extracellular sodium thus functioning as an electroneutral process. Human NHE1 has a 500 amino acid membrane domain plus a C-terminal 315 amino acid, regulatory cytosolic tail. It is regulated through a cytosolic regulatory C-terminal tail which is subject to phosphorylation and is modulated by proteins and lipids. Substantial evidence has implicated NHE1 activity in both myocardial ischemia and reperfusion damage and myocardial remodeling resulting in heart failure. Experimental data show excellent cardioprotection with NHE1 inhibitors although results from clinical results have been mixed. In cardiac surgery patients receiving the NHE1 inhibitor cariporide, subgroups showed beneficial effects of treatment. However, in one trial this was associated with a significantly increased incidence of ischemic strokes. This likely reflected both inappropriate dosing regimens as well as overly high drug doses. We suggest that further progress towards NHE1 inhibition as a treatment for cardiovascular disease is warranted through the development of novel compounds to inhibit NHE1 that are structurally different than those previously used in compromised clinical trials. Some novel pyrazinoyl guanidine inhibitors of NHE1 are already in development and the recent elucidation of the three-dimensional structure of the NHE1 protein and identity of the inhibitor binding site may facilitate development. An alternative approach may also be to control the endogenous regulation of activity of NHE1, which is activated in disease.
Manejo de dermatitis de contacto por cosméticos desde la Medicina Biorreguladora de Sistemas. Reporte de caso clínico.
Authors: Upegui Nora Alvarez , Laasch Sergio
Published: August 2022

Este caso clínico se refiere a una mujer de 65 años de edad quien al tener contacto con crema anti edad contorno de ojos que contiene Talkyl Bezoate y Prpyylene Glycol; presenta dermatitis de contacto por cosméticos tipo alérgica aguda de gran severidad.Presentando gran edema, dolor muy fuerte, prurito fuerte, eritema y vesículas en parpados y zona periocular. Clasificación en Escala Visual del Eritema EVE:3 (Ver Figura1. Escala Visual del Eritema EVE). (1) Clasificación en Escala del Dolor EVA: 9 y de Prurito: 6. (Ver Figura 2. Escala del Dolor EVA y de Prurito). (2)Es tratada con Medicina Biorreguladora de Sistemas: Adrisin como inmunomodulador, Traumeel modulador del dolor e inflamación, Lymphomyosot modulador del edema e inflamación y Atopeel que modula la inflamación y alivia el prurito. Se inicia el tratamiento con terapia de choque el primer día: Traumeel crema, Adrisin 1 tab y Traumeel 1 tab, Lymphomyosot 10 gotas; cada 15 minutos durante 2 hrs y luego cada 2 hrs por 10 hrs.La prevalencia de la dermatitis de contacto por cosméticos es del 2-4% de las consultas dermatológicas, con mayor frecuencia en mujeres y el 60% de causa alérgica. (3) El tratamiento convencional es: esteroides, antihistamínicos, anestésicos, compresas frías, antibióticos y emolientes. (4) El diagnóstico es clínico y prueba de parches cutánea.La paciente mejoro 100% con Medicina Biorreguladora de Sistemas de acuerdo a la Clasificación en Escala Visual del Eritema EVE: 0; (1) Clasificación en Escala del Dolor EVA: 0 y de Prurito: 0. (2) La importancia de este caso clínico es la respuesta terapéutica y la recuperación de los síntomas en un tiempo corto de cuatro días iniciando con terapia de choque; una recuperación eficaz en comparación con la medicina convencional que la mejoría mínima tarda tres semanas.(5)
Using the Free PERTS Growth Mindset for College Students Program with First-Year Students at a Small Liberal Arts College
Authors: Smith Tamarah
Published: August 2022

Many colleges and universities face decreasing enrollment and are therefore limited in funding to support the increasing number of students entering college underprepared. Without adequate supports, retention rates for these students decrease. This study examines a free resource that can help to support first-year students’ success and persistence in college. The Growth Mindset for College Students intervention, provided by Project for Education Research that Scales, was implemented at a small liberal arts school. Results showed that completing the intervention was related to increases in GPA and reductions in the number of students on academic probation. Implications are discussed.