bluuebunny/crossref_metadata_2025 huggingface dataset:
Recent Trends in the Business History of Russia: The Blurry Borders of the Discipline
Authors: Fava Valentina , Kulikov Volodymyr
Published: July 2022

The article analyzes recent trends in the business history of Russia and its interrelations with mainstream business history. The authors explore the extent to which the business history of Russia can contribute to the development of the discipline. To do so, they use an “alternative business history” framework. They argue that Russian business history is a disciplinary hybrid. As such, it can reasonably be considered as an interesting testing ground for business history, which seems to be searching for a new identity among history, economics, and organizational and managerial studies. In addition, Russian business history still has considerable potential for providing new voices and stories and for contributing to international debates and a more nuanced understanding of the relationship between enterprise, state, and society.
Nicholas Wiseman, The Dublin Review, and the Oxford Movement: A Study with Reference to John Henry Newman, 1836 to 1845
Authors: Andrews Robert M.
Published: July 2022

In 1836, a new Roman Catholic periodical, The Dublin Review, was founded by Nicholas Wiseman, Michael Joseph Quin, and Daniel O'Connell. Though religion was only one aspect of its intended focus, the place and identity of Roman Catholicism in post-emancipation Britain was a major emphasis. Of particular focus was the Oxford Movement (1833–1845), otherwise known as Tractarianism. Wiseman, then rector of the English College, Rome, had paid close attention to the Oxford Movement since 1833 and, via the Dublin Review, would critically engage with Tractarian literature and ideas. This paper examines this engagement from 1836 to 1845, discussing Wiseman's polemical responses to the Oxford Movement. Paying attention to the pre-history of the Dublin Review, its importance as a periodical, and its significant influence upon a handful of the leading Tractarians, especially John Henry Newman, Wiseman emerges as an influential polemicist and apologist. Respectful of Tractarian learning and zeal, Wiseman was nonetheless unambiguous in his criticisms of Tractarian ecclesiology—relentless especially in his promotion of the view that the leaders of the Oxford Movement should convert to Roman Catholicism. By 1840, the year Wiseman arrived in England as a bishop, the Dublin Review had significantly dented Newman's confidence in the Tractarian project. Wiseman, the future Cardinal Archbishop of Westminster, had, by means of the Dublin Review, made Roman Catholic views on Tractarianism known, heard, and felt in Oxford and Britain. In the case of John Henry Newman, who became a Roman Catholic in 1845, Wiseman could claim a significant victory.
Endoparasite fauna of freshwater fish from the upper Juruá River in the Western Amazon, Brazil
Authors: Virgilio L.R. , Martins W.M.O. , Lima F.S. , Takemoto R.M. , Camargo L.M.A. , Meneguetti D.U.O
Published: July 2022

The Amazon region may present a high diversity of endoparasites with a high degree of endemism. In this sense, this study describes the endoparasite fauna in freshwater fish from the Upper Juruá, in the Western Amazon. The study was carried out around the municipalities of Cruzeiro do Sul, state of Acre, and Guajará, state of Amazonas, Brazil. Fish were caught between periods of droughts and floods, using passive and active sampling methods. In the laboratory, specimens were biometrically analysed and necropsied. As a result, a total of 23,740 endoparasites were recorded, belonging to 62 species, with 91 new host reports and 91 new occurrences for the Western Amazon. Nematoda and Digenea were the most diverse and abundant groups, and the increase in host fish richness and diversity influenced the diversity and richness of endoparasites in the environments. In this sense, the present study expands the number of new reports, and contributes data on the distribution and richness of endoparasites for South America.
A phylogenetic study of a tropical sea urchin, Echinometra sp. EZ (Echinoidea: Camarodonta: Echinometridae) from the Persian Gulf
Authors: Kalantarian Seyedeh Mojgan , Archangi Bita , Valinassab Tooraj , Rajabi-Maham Hassan , Abdi Rahim
Published: August 2022

Sea urchins have important effects on marine ecosystems such as rocky shores and coral reefs across the world. However, species diversity and molecular phylogeny of most echinoid taxa are poorly known in Iran. In this study, the phylogenetic relationships of one of the most abundant species of the genus Echinometra in the Persian Gulf were examined. Echinoids were collected from the intertidal zone of Qeshm Island and Lengeh Port on March and December 2017. Morphological criteria based on valid identification keys combined with molecular analysis of a fragment of the mitochondrial cytochrome c oxidase subunit I (COI) protein-coding gene were used to delineate Echinometra species. Our analyses showed that all specimens (N = 15) belong to Echinometra sp. EZ. Tree topologies indicated that our individuals from two sampling sites formed a distinct monophyletic clade with E. sp. EZ, demonstrating high support values. This is the first phylogenetic analysis of E. sp. EZ from Iran.
Religion/Spirituality, Mental Health, and the Lifespan: Findings from a Representative Sample of Canadian Adults
Authors: Manoiu Roxana , Hammond Nicole G. , Yamin Stephanie , Stinchcombe Arne
Published: August 2022

Theories of adult development and aging suggest that older adults turn towards religion and spirituality (R/S) to increase meaning and purpose in life, and to assist in coping with adverse experience. We sought to examine the relationship between R/S and positive mental health and mental illness (i.e., psychological distress) in adulthood, and to determine the potential moderating role of age. Data from the 2012 Canadian Community Health Survey – Mental Health (CCHS-MH), a national population health study, were used. A multivariable linear regression model revealed a significant R/S by age interaction for positive mental health (p = 0.001). Although R/S was associated with positive mental health among all participants, there was a stronger relationship between R/S and positive mental health for older adults. No statistically significant relationship between R/S and psychological distress was observed. Findings highlight the importance of R/S to positive mental health across the adult lifespan. The differential relationships among R/S, positive mental health, and mental illness underscore the utility of using the dual-continua of mental health and mental illness in order to understand their respective determinants.
Bonus-Malus Scale models: creating artificial past claims history
Authors: Boucher Jean-Philippe
Published: July 2022

In recent papers, Bonus-Malus Scales (BMS) estimated using data have been considered as an alternative to longitudinal data and hierarchical data approaches to model the dependence between different contracts for the same insured. Those papers, however, did not discuss in detail how to construct and understand BMS models, and many of the BMS’s basic properties were not discussed. The first objective of this paper is to correct this situation by explaining the logic behind BMS models and by describing those properties. More particularly, we will explain how BMS models are linked with simple count regression models that have covariates associated with the past claims experience. This study could help actuaries to understand how and why they should use BMS models for experience rating. The second objective of this paper is to create artificial past claims history for each insured. This is done by combining recent panel data theory with BMS models. We show that this addition significantly improves the prediction capacity of the BMS and provides a temporary solution for insurers who do not have enough historical data. We apply the BMS model to real data from a major Canadian insurance company. Results are analysed deeply to identify specific aspects of the BMS model.
Evaluation of H19, Mest, Meg3, and Peg3 genes affecting growth and metabolism in umbilical cord blood cells of infants born to mothers with gestational diabetes and healthy mothers in Rafsanjan City, Iran
Authors: Abad Fatemeh Rahimi Mehdi , Hajizadeh Mohammad Reza , Mahmoodi Mehdi , Jalali Zahra , Kazeruni Fatemeh Nazem , Swann Jennifer , Hosseiniara Reza , Karimabad Mojgan Noroozi
Published: July 2022

Hyperglycemia during the first trimester leads to an increased risk of innate malformations as well as death at times close to delivery dates. The methylated genes include those from paternal H19 and PEG3 and those from maternal MEST and MEG3 that are necessary for the growth and regulation of the human fetus and its placenta. The aim of this study was to evaluate and compare the expression of these genes in the cord blood of healthy infants born to mothers with gestational diabetes mellitus (GDM) and healthy mothers.

This case-control study was conducted on the cord blood of 40 infants born to mothers with GDM and 35 infants born to healthy mothers. Mothers were identified by measuring oral glucose tolerance in the 24th–26th week of pregnancy. Cord blood was obtained post-delivery, and cord blood mononuclear cells were immediately extracted, using Ficoll solution. Then, RNA extraction and cDNA synthesis were performed, and gene expression of MEG3, PEG3, H19, and MEST was assessed through quantitative real-time PCR.

Findings show that the expression levels of MEG3, PEG3, H19, and MEST genes were significantly decreased in mononuclear cord blood cells of infants born to mothers with GDM when compared to those of the healthy control group.

These findings reveal that the reduction of imprinted genes in mothers with GDM is most likely due to changes in their methylation by an epigenetic process. Considering the importance of GDM due to its high prevalence and its side effects both for mother and fetus, recognizing their exact mechanisms is of high importance. This has to be studied more widely.
Acousto-optic modulators integrated on-chip
Authors: Beller Jared , Shao Linbo
Published: July 2022

Acousto-optic devices that use radio frequency mechanical waves to manipulate light are critical components in many optical systems. Here, the researchers bring acousto-optic devices on-chip and make them more efficient for integrated photonic circuits.
Progress on deuterated potassium dihydrogen phosphate (DKDP) crystals for high power laser system application
Authors: Xu Mingxia , Liu Baoan , Zhang Lisong , Ren Hongkai , Gu Qingtian , Sun Xun , Wang Shenglai , Xu Xinguang
Published: July 2022

In this review, we introduce the progress in the growth of large-aperture DKDP crystals and some aspects of crystal quality including determination of deuterium content, homogeneity of deuterium distribution, residual strains, nonlinear absorption, and laser-induced damage resistance for its application in high power laser system. Large-aperture high-quality DKDP crystal with deuteration level of 70% has been successfully grown by the traditional method, which can fabricate the large single-crystal optics with the size exceeding 400 mm. Neutron diffraction technique is an efficient method to research the deuterium content and 3D residual strains in single crystals. More efforts have been paid in the processes of purity of raw materials, continuous filtration technology, thermal annealing and laser conditioning for increasing the laser-induced damage threshold (LIDT) and these processes enable the currently grown crystals to meet the specifications of the laser system for inertial confinement fusion (ICF), although the laser damage mechanism and laser conditioning mechanism are still not well understood. The advancements on growth of large-aperture high-quality DKDP crystal would support the development of ICF in China.
Microbiome of the freshwater sponge Ephydatia muelleri shares compositional and functional similarities with those of marine sponges
Authors: Sugden Scott , Holert Johannes , Cardenas Erick , Mohn William W , Stein Lisa Y
Published: July 2022

Sponges are known for hosting diverse communities of microbial symbionts, but despite persistent interest in the sponge microbiome, most research has targeted marine sponges; freshwater sponges have been the focus of less than a dozen studies. Here, we used 16 S rRNA gene amplicon sequencing and shotgun metagenomics to characterize the microbiome of the freshwater sponge Ephydatia muelleri and identify potential indicators of sponge-microbe mutualism. Using samples collected from the Sooke, Nanaimo, and Cowichan Rivers on Vancouver Island, British Columbia, we show that the E. muelleri microbiome is distinct from the ambient water and adjacent biofilms and is dominated by Sediminibacterium, Comamonas, and unclassified Rhodospirillales. We also observed phylotype-level differences in sponge microbiome taxonomic composition among different rivers. These differences were not reflected in the ambient water, suggesting that other environmental or host-specific factors may drive the observed geographic variation. Shotgun metagenomes and metagenome-assembled genomes further revealed that freshwater sponge-associated bacteria share many genomic similarities with marine sponge microbiota, including an abundance of defense-related proteins (CRISPR, restriction-modification systems, and transposases) and genes for vitamin B12 production. Overall, our results provide foundational information on the composition and function of freshwater sponge-associated microbes, which represent an important yet underappreciated component of the global sponge microbiome.
Spatial evaluation of animal health care accessibility and veterinary shortage in France
Authors: Berrada Mehdi , Ndiaye Youba , Raboisson Didier , Lhermie Guillaume
Published: July 2022

The decrease in the supply of veterinary healthcare in France adversely affects health of food-producing animals. In a One Health perspective, the health of people, animals and their shared environment are interconnected, and adequate supply of veterinary healthcare is required to ensure public health. Prevention of outbreaks and zoonotic diseases that may impact public health mobilizes a set of public policies, including strengthening veterinary workforce. These policies should be informed by quantification of animal health care accessibility, yet this has not been well characterized. The objective was to quantify the accessibility to veterinary healthcare for cattle, swine, and poultry sectors in France. A Two-Step Floating Catchment Area (2SFCA) approach was used to measure the level of accessibility to veterinary clinics. In the cattle sector, the 2SFCA score indicated relatively high accessibility in the north and south of France, but insufficient accessibility elsewhere. In the swine sector, there was high accessibility in the north east and in north of France, medium accessibility in the south west, and insufficient accessibility elsewhere. Finally, in the poultry sector, all regions had insufficient accessibility. Sensitivity analysis examining the effects of a change in spatial accessibility according to various travel time showed that the optimal threshold to compute 2SFCA score in cattle, swine and poultry sectors were respectively, 45, 60 and 60 min. According to a definition of “underserved area” derived from an official decree and the optimal thresholds to compute 2SFCA, the cattle, swine and poultry sector have on average 75.3, 89.9 and 98.3% underserved area, respectively. We provided evidence that the supply of animal health care was not sufficient and we proposed recommendations on how to assess animal health care accessibility, enabling modelling and visualization of the effects of potential public policies aimed at reducing veterinary shortages.
Genomic analysis of a novel Neanderthal from Mezmaiskaya Cave provides insights into the genetic relationships of Middle Palaeolithic populations
Authors: Andreeva Tatiana V. , Manakhov Andrey D. , Gusev Fedor E. , Patrikeev Anton D. , Golovanova Lyubov V. , Doronichev Vladimir B. , Shirobokov Ivan G. , Rogaev Evgeny I.
Published: July 2022

The Mezmaiskaya cave is located on the North Caucasus near the border that divides Europe and Asia. Previously, fossil remains for two Neanderthals were reported from Mezmaiskaya Cave. A tooth from the third archaic hominin specimen (Mezmaiskaya 3) was retrieved from layer 3 in Mezmaiskaya Cave. We performed genome sequencing of Mezmaiskaya 3. Analysis of partial nuclear genome sequence revealed that it belongs to a Homo sapiens neanderthalensis female. Based on a high-coverage mitochondrial genome sequence, we demonstrated that the relationships of Mezmaiskaya 3 to Mezmaiskaya 1 and Stajnia S5000 individuals were closer than those to other Neanderthals. Our data demonstrate the close genetic connections between the early Middle Palaeolithic Neanderthals that were replaced by genetically distant later group in the same geographic areas. Based on mitochondrial DNA (mtDNA) data, we suggest that Mezmaiskaya 3 was the latest Neanderthal individual from the early Neanderthal’s branches. We proposed a hierarchical nomenclature for the mtDNA haplogroups of Neanderthals. In addition, we retrieved ancestral mtDNA mutations in presumably functional sites fixed in the Neanderthal clades, and also provided the first data showing mtDNA heteroplasmy in Neanderthal specimen.
Automated sleep stage scoring employing a reasoning mechanism and evaluation of its explainability
Authors: Horie Kazumasa , Ota Leo , Miyamoto Ryusuke , Abe Takashi , Suzuki Yoko , Kawana Fusae , Kokubo Toshio , Yanagisawa Masashi , Kitagawa Hiroyuki
Published: July 2022

Scoring sleep stages from biological signals is an essential but labor-intensive inspection for sleep diagnosis. The existing automated scoring methods have achieved high accuracy but are not widely applied in clinical practice. In our understanding, the existing methods have failed to establish the trust of sleep experts (e.g., physicians and clinical technologists) due to a lack of ability to explain the evidences/clues for scoring. In this study, we developed a deep-learning-based scoring model with a reasoning mechanism called class activation mapping (CAM) to solve this problem. This mechanism explicitly shows which portions of the signals support our model’s sleep stage decision, and we verified that these portions overlap with the “characteristic waves,” which are evidences/clues used in the manual scoring process. In exchange for the acquisition of explainability, employing CAM makes it difficult to follow some scoring rules. Although we concerned the negative effect of CAM on the scoring accuracy, we have found that the impact is limited. The evaluation experiment shows that the proposed model achieved a scoring accuracy of $$86.9\%$$

86.9
%

. It is superior to those of some existing methods and the inter-rater reliability among the sleep experts. These results suggest that Sleep-CAM achieved both explainability and required scoring accuracy for practical usage.
KOPI: Kinase inhibitOr Proteome Impact analysis
Authors: Li Ginny Xiaohe , Zhao Tianyun , Wang Loo Chien , Choi Hyungwon , Lim Yan Ting , Sobota Radoslaw M.
Published: July 2022

Kinase inhibitors often exert on/off-target effects, and efficient data analysis is essential for assessing these effects on the proteome. We developed a workflow for rapidly performing such a proteomic assessment, termed as kinase inhibitor proteome impact analysis (KOPI). We demonstrate KOPI’s utility with staurosporine (STS) on the leukemic K562 cell proteome. We identified systematically staurosporine’s non-kinome interactors, and showed for the first time that it caused paradoxical hyper- and biphasic phosphorylation.
Childhood deprivations predict late-life cognitive impairment among older adults in India
Authors: Muhammad T. , Debnath Paramita , Srivastava Shobhit , Sekher T. V.
Published: July 2022

Large population-based studies on the associations of childhood factors with late-life cognition are lacking in many low and middle income countries including India. In this study, we assessed the prevalence of late-life cognitive impairment and examined the associations of childhood socioeconomic status (SES) and health conditions with cognitive impairment among older adults in India. Data for this study were derived from the Longitudinal Ageing Study in India conducted in 2017–18. The effective sample size was 31,464 older adults aged 60 years and above. Cognitive functioning was measured through five global domains (memory, orientation, arithmetic function, executive function, and object naming). The overall score ranged between 0 and 43, and the score was reversed indicating cognitive impairment. Descriptive statistics along with mean scores of cognitive impairment were presented. Additionally, moderated multivariable linear regression models were employed to examine the association between explanatory variables, including childhood SES and health conditions and late-life cognitive impairment. The mean score of cognitive functioning among the study participants was 21.72 (CI 2.64–21.80). About 15% of older adults had poor health conditions, and 44% had lower financial status during their childhood. Older adults who had a fair health during their childhood were more likely to suffer from cognitive impairment in comparison to older adults who had good health during their childhood (Coef: 0.60; CI 0.39, 0.81). In comparison to older adults who had good childhood financial status, those who had poor childhood financial status were more likely to suffer from cognitive impairment (Coef: 0.81; CI 0.56, 1.07). Older adults who had fair childhood health status and poor childhood financial status were more likely to suffer from cognitive impairment in comparison to older adults who had good childhood health and good financial status (Coef: 1.26; CI 0.86, 1.66). Social policies such as improving educational and financial resources in disadvantaged communities and socioeconomically poor children and their families, would help to enhance a better cognitive ageing and a healthy and dignified life in old age.
Genome-wide association study of Senegalese sorghum seedlings responding to a Texas isolate of Colletotrichum sublineola
Authors: Ahn Ezekiel , Fall Coumba , Prom Louis K. , Magill Clint
Published: July 2022

Colletotrichum sublineola is a destructive fungal pathogen that causes anthracnose in sorghum. Senegalese sorghum germplasm is currently being considered as an option of sources for genetic resistance. In a recent study, Senegalese sorghum accessions were evaluated for response to a mixture of Texas isolates of C. sublineola at the 8-leaf stage in the greenhouse. As a comparison, 159 Senegalese sorghum accessions at the 1-leaf developmental stage were evaluated against a single Texas isolate of C. sublineola (FSP53) using an excised-leaf assay. A genome-wide association study (GWAS) was conducted based on the phenotypic data acquired to discover genetic variation associated with response to C. sublineola using 193,727 single nucleotide polymorphisms (SNPs) throughout the genome. Sorghum seedlings tended to be more resistant when compared with sorghum plants inoculated at the 8-leaf stage in the greenhouse in previous experiments. Based on the highest score evaluated in the 1-leaf developmental stage excised leaf assay for each accession, 16 accessions were labeled as susceptible. GWAS identified the SNP locus S01_72868925 that is associated with protein kinase domain // Leucine rich repeat N-terminal domain at a level of confidence that surpassed Bonferroni correction. Along with the SNP locus S01_72868925, other top SNP loci were also associated with genes that are known to play critical roles in plant defense or plant stress responses.
Automated histological classification for digital pathology images of colonoscopy specimen via deep learning
Authors: Byeon Sun-ju , Park Jungkap , Cho Yoon Ah , Cho Bum-Joo
Published: July 2022

Colonoscopy is an effective tool to detect colorectal lesions and needs the support of pathological diagnosis. This study aimed to develop and validate deep learning models that automatically classify digital pathology images of colon lesions obtained from colonoscopy-related specimen. Histopathological slides of colonoscopic biopsy or resection specimens were collected and grouped into six classes by disease category: adenocarcinoma, tubular adenoma (TA), traditional serrated adenoma (TSA), sessile serrated adenoma (SSA), hyperplastic polyp (HP), and non-specific lesions. Digital photographs were taken of each pathological slide to fine-tune two pre-trained convolutional neural networks, and the model performances were evaluated. A total of 1865 images were included from 703 patients, of which 10% were used as a test dataset. For six-class classification, the mean diagnostic accuracy was 97.3% (95% confidence interval [CI], 96.0–98.6%) by DenseNet-161 and 95.9% (95% CI 94.1–97.7%) by EfficientNet-B7. The per-class area under the receiver operating characteristic curve (AUC) was highest for adenocarcinoma (1.000; 95% CI 0.999–1.000) by DenseNet-161 and TSA (1.000; 95% CI 1.000–1.000) by EfficientNet-B7. The lowest per-class AUCs were still excellent: 0.991 (95% CI 0.983–0.999) for HP by DenseNet-161 and 0.995 for SSA (95% CI 0.992–0.998) by EfficientNet-B7. Deep learning models achieved excellent performances for discriminating adenocarcinoma from non-adenocarcinoma lesions with an AUC of 0.995 or 0.998. The pathognomonic area for each class was appropriately highlighted in digital images by saliency map, particularly focusing epithelial lesions. Deep learning models might be a useful tool to help the diagnosis for pathologic slides of colonoscopy-related specimens.
Systemic long-term metabolic effects of acute non-severe paediatric burn injury
Authors: Begum Sofina , Johnson Blair Z. , Morillon Aude-Claire , Yang Rongchang , Bong Sze How , Whiley Luke , Gray Nicola , Fear Vanessa S. , Cuttle Leila , Holland Andrew J. A. , Nicholson Jeremy K. , Wood Fiona M. , Fear Mark W. , Holmes Elaine
Published: July 2022

A growing body of evidence supports the concept of a systemic response to non-severe thermal trauma. This provokes an immunosuppressed state that predisposes paediatric patients to poor recovery and increased risk of secondary morbidity. In this study, to understand the long-term systemic effects of non-severe burns in children, targeted mass spectrometry assays for biogenic amines and tryptophan metabolites were performed on plasma collected from child burn patients at least three years post injury and compared to age and sex matched non-burn (healthy) controls. A panel of 12 metabolites, including urea cycle intermediates, aromatic amino acids and quinolinic acid were present in significantly higher concentrations in children with previous burn injury. Correlation analysis of metabolite levels to previously measured cytokine levels indicated the presence of multiple cytokine-metabolite associations in the burn injury participants that were absent from the healthy controls. These data suggest that there is a sustained immunometabolic imprint of non-severe burn trauma, potentially linked to long-term immune changes that may contribute to the poor long-term health outcomes observed in children after burn injury.
CombPDX: a unified statistical framework for evaluating drug synergism in patient-derived xenografts
Authors: Huang Licai , Wang Jing , Fang Bingliang , Meric-Bernstam Funda , Roth Jack A. , Ha Min Jin
Published: July 2022

Anticancer combination therapy has been developed to increase efficacy by enhancing synergy. Patient-derived xenografts (PDXs) have emerged as reliable preclinical models to develop effective treatments in translational cancer research. However, most PDX combination study designs focus on single dose levels, and dose–response surface models are not appropriate for testing synergism. We propose a comprehensive statistical framework to assess joint action of drug combinations from PDX tumor growth curve data. We provide various metrics and robust statistical inference procedures that locally (at a fixed time) and globally (across time) access combination effects under classical drug interaction models. Integrating genomic and pharmacological profiles in non-small-cell lung cancer (NSCLC), we have shown the utilities of combPDX in discovering effective therapeutic combinations and relevant biological mechanisms. We provide an interactive web server, combPDX (https://licaih.shinyapps.io/CombPDX/), to analyze PDX tumor growth curve data and perform power analyses.
Two-step movement of tsunami boulders unveiled by modified viscous remanent magnetization and radiocarbon dating
Authors: Sato Tetsuro , Sato Masahiko , Yamada Masaki , Saito Hirotake , Satake Kenji , Nakamura Norihiro , Goto Kazuhisa , Miyairi Yosuke , Yokoyama Yusuke
Published: July 2022

Massive boulders in landslide and tsunami deposits are prominent geomorphic features in various landscapes. Tracking their movement history is important for reconstructing past geologic dynamics; however, the reworking movements of massive boulders remain unresolved. The boulder field on the Ishigaki Island was formed by repeated tsunamis. Although the individual movement histories of boulders contribute to retrodict the history of different magnitude tsunamis, their radiocarbon ages only correspond to the tsunamis that detached boulders from the reef. Viscous remanent magnetization dating methods have been applied in reworking movements. These methods reveal signals associated with remanent magnetization that gradually grew since the reworking event, which helps to determine the passage of time. The methods were verified by comparison to the radiocarbon ages of un-reworked boulders detached by the recent Meiwa tsunami, while the estimated ages of such two boulders based on the classical relaxation theory contradicted the radiocarbon ages. Here, we show that a method based on the stretched exponential function addressed this contradiction. The reworking movement was estimated using an additional boulder, whose, using our method, radiocarbon age indicated that an older tsunami moved it, whereas the remanent magnetization age unveiled a reworking of the boulder attributed to the Meiwa tsunami.
A population-based retrospective study of the modifying effect of urban blue space on the impact of socioeconomic deprivation on mental health, 2009–2018
Authors: Georgiou Michail , Tieges Zoë , Morison Gordon , Smith Niamh , Chastin Sebastien
Published: July 2022

The incidence of mental health disorders in urban areas is increasing and there is a growing interest in using urban blue spaces (urban waterways, canals, lakes, ponds, coasts, etc.) as a tool to manage and mitigate mental health inequalities in the population. However, there is a dearth of longitudinal evidence of the mechanisms and impact of blue spaces on clinical markers of mental health to support and inform such interventions. We conducted a 10-year retrospective study, following STROBE guidelines, using routinely collected population primary care health data within the National Health Service (NHS) administrative area of Greater Glasgow and Clyde for the North of Glasgow city area. We explored whether living near blue space modifies the negative effect of socio-economic deprivation on mental health during the regeneration of an urban blue space (canal) from complete dereliction and closure. A total of 132,788 people (65,351 female) fulfilling the inclusion criteria were entered in the analysis. We established a base model estimating the effect of deprivation on the risk of mental health disorders using a Cox proportional hazards model, adjusted for age, sex and pre-existing comorbidities. We then investigated the modifying effect of living near blue space by computing a second model which included distance to blue space as an additional predicting variable and compared the results to the base model. Living near blue space modified the risk of mental health disorders deriving from socio-economic deprivation by 6% (hazard ratio 2.48, 95% confidence interval 2.39–2.57) for those living in the most deprived tertile (T1) and by 4% (hazard ratio 1.66, 95% confidence interval 1.60–1.72) for those in the medium deprivation tertile (T2). Our findings support the notion that living near blue space could play an important role in reducing the burden of mental health inequalities in urban populations.
Multiparametric cloth-based wearable, SimpleSense, estimates blood pressure
Authors: Kumar Prashanth Shyam , Rai Pratyush , Ramasamy Mouli , Varadan Venkatesh K. , Varadan Vijay K.
Published: July 2022

Targeted maintenance of blood pressure for hypertensive patients requires accurate monitoring of blood pressure at home. Use of multiparametric vital signs ECG, heart sounds, and thoracic impedance for blood pressure estimation at home has not been reported previously. In an observational multi-site study, 120 subjects (female (N = 61, 52%)) between 18 and 83 years of age were recruited with the following stratification (Normal (20%), prehypertensive (37%), stage 1(26%), and stage 2 (18%). From these subjects, 1686 measurements of blood pressure from a sphygmomanometer were associated with simultaneously acquired signals from the SimpleSense device. An ensemble of tree-based models was trained with inputs as metrics derived from the multiparametric and patient demographics data. A test Mean Absolute Difference (MAD) of ± 6.38 mm of Hg and ± 5.10 mm of Hg were obtained for systolic and diastolic blood pressures (SBP; DBP), respectively. Comparatively, the MAD for wrist-worn blood pressure cuff OMRON BP6350 (GUDID—10073796266353) was ± 8.92 mm of Hg and ± 6.86 mm of Hg, respectively. Machine learning models trained to use multiparametric data can monitor SBP and DBP without the need for calibration, and with accuracy levels comparable to at-home cuff-based blood pressure monitors.
Unlocking the access to oxidized coenzyme A via a single-step green membrane-based purification
Authors: Mouterde Louis M. M. , Willig Gaëlle , Langlait Maxime M. J. , Brunois Fanny , Chadni Morad , Allais Florent
Published: July 2022

A new membrane-based strategy to purify oxidized coenzyme A ((CoAS)2) from adenosine triphosphate (ATP), adenosine diphosphate (ADP) and adenosine monophosphate (AMP) has been developed. Commercially available membranes were screened and studied (permeate flux and overall compounds retention) which allowed the identification of one efficient membrane (GK from Suez Water Technologies & Solutions). Different total compounds concentrations solutions were used in the system in order to find the following working conditions: 4 bars with a total compounds solution of 5.19 g L−1. Applying these conditions to a dia-filtration set-up allowed us to reach 68% pure (CoAS)2 in 4.8 diafiltration volumes (DV) and a 95% (CoAS)2 purity can be predicted in 8.5 DV. A comparative study of green metrics—i.e. process mass index (PMI)—of the classic chromatography vs the membrane-based one demonstrated the great advantages of the latter in terms of sustainability. This strategy unlocks the access to the essential and central cofactor that is coenzyme A.
Association between a dietary pattern high in saturated fatty acids, dietary energy density, and sodium with coronary heart disease
Authors: Abu Bakar Nur Ain Fatinah , Ahmad Aryati , Wan Musa Wan Zulaika , Shahril Mohd Razif , Wan-Arfah Nadiah , Abdul Majid Hazreen , Piernas Carmen , Ramli Ahmad Wazi , Naing Nyi Nyi
Published: July 2022

This study aimed to determine the association between dietary pattern (DP) and coronary heart disease (CHD) among high-risk adults as determined by metabolic syndrome (MetS) criteria in Malaysia. This cross-sectional study involved 365 participants with (CHD = 178; non-CHD = 187) who were recruited from selected health clinics. Dietary intake was measured using a 189-item semi-quantitative foods frequency questionnaire (FFQ) whilst anthropometry and clinical data were measured by trained researcher and biochemical data were obtained from medical records. The reduced rank regression (RRR) method was used to derive DPs scores and binary logistic regression was used to assess the associations between identified DPs and CHD. The main DP found in this study was characterised by “high saturated fatty acid (SFA), high dietary energy density (DED), high sodium”. This DP, which is attributed to high consumption of coconut-based dishes, fast foods and snacks, rice dishes, fat spread, seasoning sauces, salted and processed foods, and low intake of fruits, green leafy vegetables, white rice and other vegetables were associated with CHD (OR:1.32, 95% CI:1.03, 1.69) p value = 0.026 when, adjusted for age, sex, race, education level, household income, family history of CHD, marital status, smoking status, physical activity, stress level and BMI. This study suggests that individuals with a DP of high SFA, high DED, and high sodium have a significantly increased likelihood of having CHD compared to those who do not practice this DP.
Spatiotemporal changes in influenza A virus prevalence among wild waterfowl inhabiting the continental United States throughout the annual cycle
Authors: Kent Cody M. , Ramey Andrew M. , Ackerman Joshua T. , Bahl Justin , Bevins Sarah N. , Bowman Andrew S. , Boyce Walter M. , Cardona Carol J. , Casazza Michael L. , Cline Troy D. , E. De La Cruz Susan , Hall Jeffrey S. , Hill Nichola J. , Ip Hon S. , Krauss Scott , Mullinax Jennifer M. , Nolting Jacqueline M. , Plancarte Magdalena , Poulson Rebecca L. , Runstadler Jonathan A. , Slemons Richard D. , Stallknecht David E. , Sullivan Jeffery D. , Takekawa John Y. , Webby Richard J. , Webster Robert G. , Prosser Diann J.
Published: July 2022

Avian influenza viruses can pose serious risks to agricultural production, human health, and wildlife. An understanding of viruses in wild reservoir species across time and space is important to informing surveillance programs, risk models, and potential population impacts for vulnerable species. Although it is recognized that influenza A virus prevalence peaks in reservoir waterfowl in late summer through autumn, temporal and spatial variation across species has not been fully characterized. We combined two large influenza databases for North America and applied spatiotemporal models to explore patterns in prevalence throughout the annual cycle and across the continental United States for 30 waterfowl species. Peaks in prevalence in late summer through autumn were pronounced for dabbling ducks in the generaAnasandSpatula, but notMareca. Spatially, areas of high prevalence appeared to be related to regional duck density, with highest predicted prevalence found across the upper Midwest during early fall, though further study is needed. We documented elevated prevalence in late winter and early spring, particularly in the Mississippi Alluvial Valley. Our results suggest that spatiotemporal variation in prevalence outside autumn staging areas may also represent a dynamic parameter to be considered in IAV ecology and associated risks.
Association between amorphous calcium-phosphate ratios in circulating calciprotein particles and prognostic biomarkers in hemodialysis patients
Authors: Nakamura Kimihiko , Isoyama Naohito , Nakayama Yuki , Hiroyoshi Toshiya , Fujikawa Koki , Miura Yutaka , Kurosu Hiroshi , Matsuyama Hideyasu , Kuro-o Makoto
Published: July 2022

Calciprotein particles (CPPs) are circulating colloidal mineral-protein complexes containing crystalline and/or non-crystalline (amorphous) calcium-phosphate (CaPi). Serum CPP levels correlate with vascular stiffness and calcification in patients with chronic kidney disease (CKD). In vitro studies showed that CPPs containing crystalline CaPi were more arteriosclerogenic and inflammogenic than CPPs without containing crystalline CaPi. Thus, we hypothesized that not only the quantity but also the quality of CPPs (the phase of CaPi) might affect clinical outcomes. To test this hypothesis, we quantified amorphous CaPi ratio defined as the ratio of the amorphous CaPi amount to the total CaPi amount in serum CPPs from 183 hemodialysis patients and explored its possible correlation with serum parameters associated with prognosis of hemodialysis patients. Multivariate analysis revealed that the amorphous CaPi ratio correlated positively with hemoglobin and negatively with fibroblast growth factor-21 (FGF21), which remained significant after adjusting for the total CaPi amount. Because low hemoglobin and high FGF21 are associated with increased mortality, the present study warrants further studies to determine whether low amorphous CaPi ratio in circulating CPPs may be associated with poor prognosis in hemodialysis patients.
Diurnal changes of noninvasive parameters of ocular surface in healthy subjects before and after continuous face mask wearing during the COVID-19 pandemic
Authors: Giannaccare Giuseppe , Pellegrini Marco , Borselli Massimiliano , Senni Carlotta , Bruno Angela , Scorcia Vincenzo
Published: July 2022

To investigate whether diurnal changes in noninvasive ocular surface parameters and subjective symptoms occur in healthy subjects wearing face mask who were analyzed before and after 8 h of continuous use. In this prospective cross-sectional study, healthy volunteers attending the same workplace environment underwent a noninvasive ocular surface workup by means of Keratograph 5 M (Oculus, Wetzlar, Germany) in the same day at 2 different time points: (i) in the early morning before wearing face mask (T0); (ii) after 8 h of continuous face mask use (T1). Noninvasive break-up time (NIBUT), tear meniscus height (TMH), ocular redness and meibomian gland dropout were measured. All subjects were asked to complete the Ocular Surface Disease Index (OSDI) questionnaire before and after 8 h of face mask wearing. Data from 20 healthy subjects (10 males and 10 females, mean age 25.1 ± 3.9 years) were included. Mean value of TMH decreased significantly from 0.29 ± 0.07 at T0 to 0.23 ± 0.07 mm at T1 (P < 0.001); conversely, mean values of NIBUT, redness score and meibomian gland dropout did not change significantly after continuous face mask wearing (alwaysP > 0.532). Concerning ocular discomfort symptoms, mean value of OSDI score worsened significantly at T1 compared to T0 (from 12.9 ± 12.6 to 19.4 ± 12.0;P = 0.017). Continuous face mask wearing for 8 h led to decreased TMH associated with the onset of ocular discomfort symptoms in young healthy subjects.
Paradoxical effects of altruism on efforts to mitigate climate change
Authors: Fossas-Tenas A. , Ibelings B. W. , Kasparian J. , Krishnakumar J. , Laurent-Lucchetti J.
Published: July 2022

It is common wisdom that altruism is a crucial element in addressing climate change and other public good issues. If individuals care about the welfare of others (including future generations) they can be expected to unilaterally adapt their behaviour to preserve the common good thus enhancing the wellbeing of all. We introduce a network game model featuring both altruism and a public good (e.g. climate) whose degradation affects all players. As expected, in an idealistic fully connected society where all players care about each other, increasing altruism results in a better protection of the public good. However, in more realistic networks where people are not all related to each other, we highlight an intrinsic trade-off between the effects of altruism on reducing inequality and the preservation of a global public good: the consumption redistribution generated by a higher altruism is partly achieved by lowering income transfers towards protection of the public good. Therefore, it increases overall consumption and is thereby detrimental to the public good. These results suggest that altruism, although good from a welfarist point of view, is not in itself sufficient to simultaneously solve public good and inequality issues.
Applying the concept of liquid biopsy to monitor the microbial biodiversity of marine coastal ecosystems
Authors: Ferchiou Sophia , Caza France , de Boissel Philippine Granger Joly , Villemur Richard , St-Pierre Yves
Published: July 2022

Liquid biopsy (LB) is a concept that is rapidly gaining ground in the biomedical field. Its concept is largely based on the detection of circulating cell-free DNA (ccfDNA) fragments that are mostly released as small fragments following cell death in various tissues. A small percentage of these fragments are from foreign (nonself) tissues or organisms. In the present work, we applied this concept to mussels, a sentinel species known for its high filtration capacity of seawater. We exploited the capacity of mussels to be used as natural filters to capture environmental DNA fragments of different origins to provide information on the biodiversity of marine coastal ecosystems. Our results showed that hemolymph of mussels contains DNA fragments that varied considerably in size, ranging from 1 to 5 kb. Shotgun sequencing revealed that a significant amount of DNA fragments had a nonself microbial origin. Among these, we found DNA fragments derived from bacteria, archaea, and viruses, including viruses known to infect a variety of hosts that commonly populate coastal marine ecosystems. Taken together, our study shows that the concept of LB applied to mussels provides a rich and yet unexplored source of knowledge regarding the microbial biodiversity of a marine coastal ecosystem.
Refined high-pressure tube design for improved resolution in high-pressure NMR spectroscopy
Authors: Duchowny Anton , Ortiz Restrepo Sergio Alejandro , Adams Michael , Thelen Ralf , Adams Alina
Published: July 2022

A simple, low-cost, and easy-to-replicate high-pressure sapphire tube for NMR spectroscopy experiments is introduced. The significant improvement in spectral resolution enables, e.g., in situ quantification of the H2 ingress in green solvents.
Dynamicin vitrohemocompatibility of oligoproline self-assembled monolayer surfaces
Authors: Mzyk Aldona , Imbir Gabriela , Noguchi Yuri , Sanak Marek , Major Roman , Wiecek Justyna , Kurtyka Przemyslaw , Plutecka Hanna , Trembecka-Wójciga Klaudia , Iwasaki Yasuhiko , Ueda Masato , Kakinoki Sachiro
Published: July 2022

The blood compatibility of self-assembled monolayers (SAMs) of oligoproline, a nonionic antifouling peptide, was investigated using the cone-and-plate assay imitating arterial blood flow conditions.
NOAH-(15N/13C)-CEST NMR supersequence for dynamics studies of biomolecules
Authors: Cabrera Allpas Rodrigo , Hansen Alexandar L. , Brüschweiler Rafael
Published: July 2022

A NOAH-CEST NMR supersequence is introduced allowing the simultaneous acquisition of 15N and 13C-CEST experiments of proteins, resulting in the characterization of backbone and methyl side-chain dynamics from a single measurement.
Plasma-induced defect engineering of porous metal–organic framework nanosheet arrays for efficient water splitting
Authors: Song Junnan , Zhao Sheng , Liu Di , Xiong Yixing , Hu Feng , Li Linlin , Li Lei , Pan Hui , Peng Shengjie
Published: July 2022

A simple, green, and rapid plasma treatment was introduced to etch MOF nanosheet arrays, which present superior difunctional electrocatalytic activity and stability towards both the OER and HER, due to abundant active sites and fast reaction kinetics.
The destructive mechanism of Aβ1–42 protofibrils by norepinephrine revealed via molecular dynamics simulations
Authors: Gao Duo , Wan Jiaqian , Zou Yu , Gong Yehong , Dong Xuewei , Xu Zhengdong , Tang Jiaxing , Wei Guanghong , Zhang Qingwen
Published: July 2022

The destructive mechanism of Aβ1–42 protofibrils by protonated and deprotonated norepinephrine revealed via molecular dynamics simulations.
Simulation of the photodetachment spectra of the nitrate anion (NO3−) in the B̃ 2E′ energy range and non-adiabatic electronic population dynamics of NO3
Authors: Williams David M. G. , Eisfeld Wolfgang , Viel Alexandra
Published: July 2022

Quantum dynamics simulations demonstrate the presence of ultra-fast non-statistical and slow statistical non-radiative decay and the presence of active and inactive conical intersections in NO3.