bluuebunny/crossref_metadata_2025 huggingface dataset:
Simple HPLC-UV Method for Therapeutic Drug Monitoring of 12 Antiepileptic Drugs and Their Main Metabolites in Human Plasma
Authors: Milosheska Daniela , Roškar Robert
Published: November 2023

The objective of the present report was to develop and validate a simple, selective, and reproducible high-performance liquid chromatography method with UV detection suitable for routine therapeutic drug monitoring of the most commonly used antiepileptic drugs and some of their metabolites. Simple precipitation of plasma proteins with acetonitrile was used for sample preparation. 10,11-dihydrocarbamazepine was used as an internal standard. Chromatographic separation of the analytes was achieved by gradient elution on a Phenyl–Hexyl column at 40 °C, using methanol and potassium phosphate buffer (25 mM; pH 5.1) as a mobile phase. The method was validated according to the FDA guidelines for bioanalytical method validation. It showed to be selective, accurate, precise, and linear over the concentration ranges of 1–50 mg/L for phenobarbital, phenytoin, levetiracetam, rufinamide, zonisamide, and lacosamide; 0.5–50 mg/L for lamotrigine, primidone, carbamazepine and 10-monohydroxycarbazepine; 0.2–10 mg/L for carbamazepine metabolites: 10,11-trans-dihydroxy-10,11-dihydrocarbamazepine and carbamazepine-10,11-epoxide; 0.1–10 mg/L for oxcarbazepine; 2–100 mg/L for felbamate and 3–150 mg/L for ethosuximide. The suitability of the validated method for routine therapeutic drug monitoring was confirmed by quantification of the analytes in plasma samples from patients with epilepsy on combination antiepileptic therapy.
(−)-Epigallocatechin-3-Gallate Reduces Perfluorodecanoic Acid-Exacerbated Adiposity and Hepatic Lipid Accumulation in High-Fat Diet-Fed Male C57BL/6J Mice
Authors: Xu Hong , Zhong Xu , Wang Taotao , Wu Shanshan , Guan Huanan , Wang Dongxu
Published: November 2023

Perfluorodecanoic acid (PFDA), an enduring and harmful organic pollutant, is widely employed in diverse food-related sectors. Our previous studies have provided evidence that PFDA has the potential to facilitate obesity and hepatic fat accumulation induced by high-fat diet (HFD) intake. Epigallocatechin-3-gallate (EGCG), a polyphenol found in green tea, has been suggested to possess potential preventive effects against metabolic abnormalities and fatty liver. The purpose of this research was to investigate the effects of EGCG on PFDA-exacerbated adiposity and hepatic lipid accumulation in HFD-fed mice. The results showed that EGCG reduced body weight gain; tissue and organ weights; blood glucose, serum insulin, HOMA-IR, leptin, and lipid parameters; serum inflammatory cytokines (IL−1β, IL−18, IL−6, and TNF−α); and hepatic lipid accumulation in PFDA-exposed mice fed an HFD. Further work showed that EGCG improved liver function and glucose homeostasis in mice fed an HFD and co-exposed to PFDA. The elevated hepatic mRNA levels of SREBP-1 and associated lipogenic genes, NLRP3, and caspase−1 in PFDA-exposed mice fed an HFD were significantly decreased by EGCG. Our work provides evidence for the potential anti-obesity effect of EGCG on co-exposure to HFD and PFDA and may call for further research on the bioactivity of EGCG to attenuate the endocrine disruption effects of long-term exposure to pollutants.
Positive and Negative Contribution from Lead–Oxygen Groups and Halogen Atoms to Birefringence: A First Principles Investigation
Authors: Deng Can , Wang Jialong , Hu Mei , Cui Xiuhua , Duan Haiming , Li Peng , Lee Ming-Hsien
Published: November 2023

Oxyhalides, containing oxygen and halogen atoms and combining the advantages of oxides and halides in geometry and optical response, have great potential in optical materials. In this study, the electronic structures and the optical properties of the Pb3O2X2 (X = Cl, Br, I) compounds have been investigated using the first principles method. The results show that these compounds have birefringence at 0.076, 0.078, and 0.059 @ 1064 nm, respectively. And, the asymmetric stereochemical active lone pair electrons were found around lead atoms, which were confirmed by the projected density of states, the electronic localization functions, and the crystal orbitals. The contribution of atoms and polyhedra to birefringence was further evaluated using the Born effective charge. The results show that halogen atoms give negative contribution, and lead—oxygen polyhedra give positive contribution. The spin—orbit coupling effect is also investigated, and the downshift of the conduction band and variation in the valence band are found after relevant spin—orbit coupling (SOC), which leads to a reduction in the band gap and birefringence.
Diagnosis in Scrapie: Conventional Methods and New Biomarkers
Authors: Sola Diego , Betancor Marina , Marco Lorente Paula A. , Pérez Lázaro Sonia , Barrio Tomás , Sevilla Eloisa , Marín Belén , Moreno Bernardino , Monzón Marta , Acín Cristina , Bolea Rosa , Badiola Juan J. , Otero Alicia
Published: November 2023

Scrapie, a naturally occurring prion disease affecting goats and sheep, comprises classical and atypical forms, with classical scrapie being the archetype of transmissible spongiform encephalopathies. This review explores the challenges of scrapie diagnosis and the utility of various biomarkers and their potential implications for human prion diseases. Understanding these biomarkers in the context of scrapie may enable earlier prion disease diagnosis in humans, which is crucial for effective intervention. Research on scrapie biomarkers bridges the gap between veterinary and human medicine, offering hope for the early detection and improved management of prion diseases.
Effects of Lactate Transport Inhibition by AZD3965 in Muscle-Invasive Urothelial Bladder Cancer
Authors: Silva Ana , Félix Ana , Cerqueira Mónica , Gonçalves Céline S. , Sampaio-Marques Belém , Longatto-Filho Adhemar , Baltazar Fátima , Afonso Julieta
Published: November 2023

The Warburg Effect is characterized by high rates of glucose uptake and lactate production. Monocarboxylate transporters (MCTs) are crucial to avoid cellular acidosis by internal lactate accumulation, being largely overexpressed by cancer cells and associated with cancer aggressiveness. The MCT1-specific inhibitor AZD3965 has shown encouraging results in different cancer models. However, it has not been tested in urothelial bladder cancer (UBC), a neoplasm where rates of recurrence, progression and platinum-based resistance are generally elevated. We used two muscle-invasive UBC cell lines to study AZD3965 activity regarding lactate production, UBC cells’ viability and proliferation, cell cycle profile, and migration and invasion properties. An “in vivo” assay with the chick chorioallantoic membrane model was additionally performed, as well as the combination of the compound with cisplatin. AZD3965 demonstrated anticancer activity upon low levels of MCT4, while a general lack of sensitivity was observed under MCT4 high expression. Cell viability, proliferation and migration were reduced, cell cycle was arrested, and tumor growth “in vivo” was inhibited. The compound sensitized these MCT4-low-expressing cells to cisplatin. Thus, AZD3965 seems to display anticancer properties in UBC under a low MCT4-expression setting, but additional studies are necessary to confirm AZD3965 activity in this cancer model.
Assembly of Tomato Rhizobacteria from Different Functional Groups Improves Seedling Photosynthesis and Growth
Authors: Zhao Yi , Hong Yingqi , Wang Peng , Gou Yirong , Zeng Rensen , Zhang Qianrong , Chen Dongmei , Song Yuanyuan
Published: November 2023

The rhizosphere harbors abundant plant growth-promoting rhizobacteria (PGPR) that are vital for plant health. In this study, we screened growth-promoting bacteria from tomato rhizosphere soil, verified their functions, and constructed the optimal combination of growth-promoting bacteria for promoting tomato growth. Furthermore, the effects of these bacteria on various physiological and biochemical parameters of tomato plants were evaluated. A total of 36 strains of rhizobacteria were isolated from tomato rhizosphere soil and their abilities to produce indole-3-acetic acid (IAA), solubilize phosphate and iron carriers were assessed. The bacterial strains with the highest capacities for IAA production (R62, R317), phosphate solubilization (R41, R219), and siderophore production (R25, R325) were selected to form three bacterial combinations: R62 + R219 + R317 + R325 (T1), R62 + R325 (T5), and R317 + R325 (T8). Fifteen days after inoculation, all three combinations showed a stimulatory effect on seedling growth compared to the un-inoculated control. Inoculation with T1, T5 and T8 increased the seedling vigor index by 173.7%, 204.1%, and 168.7%, respectively. Compared to the un-inoculated control, the T1 combination increased the activities of polyphenol oxidase, peroxidase, and the net photosynthetic rate by 132.7%, 18.7%, 58.5%, and upregulated the relative expression levels of the photosynthetic assimilation-related genes RbcL, RbcS, FBPase and FDA by 22.2-, 6.6-, 1.95-, and 2.0-fold, respectively. Our findings provide a potential for constructing rhizobacterial combinations of different functional groups for improving crop growth.
Novel Pathogen–Plant Host Interaction: Colletotrichum jiangxiense and Fraxinus americana L. (White Ash) in a Sentinel Garden in China
Authors: Chang Lin , Li Yilin , Gao Ziwen , Bonello Pierluigi (Enrico) , Cleary Michelle , Munck Isabel A. , Santini Alberto , Sun Hui
Published: November 2023

Fraxinus americana L. (white ash), a native North American tree commonly cultivated for its ornamental qualities, displayed symptoms of leaf spot disease in a sentinel garden located in Nanjing, Jiangsu, China, in 2022. This disease led to premature leaf shedding, adversely affecting the plant’s growth and substantially diminishing its ornamental value. Potential fungal pathogens were isolated from the diseased leaves and the subsequent application of Koch’s postulates confirmed the pathogenicity of the fungal isolates (BL-1, BL-2). Through a combination of multi-locus phylogenetic analysis, including ITS, ACT, ApMat, CAL, CHS-1, GAPDH, and TUB2, alongside morphological assessments, the fungus was conclusively identified as Colletotrichum jiangxiense. This represents the first record of C. jiangxiense affecting white ash, highlighting the important role of sentinel gardens in uncovering novel pathogen–plant host interactions.
Experimental Progress in the Development of a Metal Foil Pump for DEMO
Authors: Kathage Yannick , Vazquez Cortes Alejandro , Merli Stefan , Day Christian , Giegerich Thomas , Hanke Stefan , Igitkhanov Juri , Schulz Andreas , Walker Matthias
Published: November 2023

Experimental findings to contribute to the preliminary design of a metal foil pump for fuel separation in the Direct Internal Recycling loop of the DEMO fusion device are presented. In parametric studies on a small-scale superpermeation experiment with a microwave plasma source and two different metal foil materials, niobium Nb and vanadium V, a substantial increase in permeation with plasma power and with a decrease in pressure was observed. To ease operation in the typical fusion environment, in-situ heating procedures were developed to recover from impurity contamination. The temperature independence of plasma-driven permeation from 600 to 900 °C metal foil temperature was demonstrated. No proof of an isotopic effect for plasma-driven permeation of protium and deuterium could be found. The highest repeatable permeation flux achieved was 6.7 Pa∙m3/(m2∙s) or ~5.5 × 10−3 mol H/(m2∙s). The found compression ratios do safely allow the operation of the metal foil pump using ejector pumps as backing stages for the permeate. In a dedicated experimental setup, the operation of the plasma source in a strong magnetic field was tested. Parametric studies of pressure, power input, magnetic flux density, field gradient and field angle are presented.
A Study of the Relationship between Polymer Solution Entanglement and Electrospun PCL Fiber Mechanics
Authors: Rajeev Manasa , Helms Christine C.
Published: November 2023

Electrospun fibers range in size from nanometers to micrometers and have a multitude of potential applications that depend upon their morphology and mechanics. In this paper, we investigate the effect of polymer solution entanglement on the mechanical properties of individual electrospun polycaprolactone (PCL) fibers. Multiple concentrations of PCL, a biocompatible polymer, were dissolved in a minimum toxicity solvent composed of acetic acid and formic acid. The number of entanglements per polymer (ne) in solution was calculated using the polymer volume fraction, and the resultant electrospun fiber morphology and mechanics were measured. Consistent electrospinning of smooth fibers was achieved for solutions with ne ranging from 3.8 to 4.9, and the corresponding concentration of 13 g/dL to 17 g/dL PCL. The initial modulus of the resultant fibers did not depend upon polymer entanglement. However, the examination of fiber mechanics at higher strains, performed via lateral force atomic force microscopy (AFM), revealed differences among the fibers formed at various concentrations. Average fiber extensibility increased by 35% as the polymer entanglement number increased from a 3.8 ne solution to a 4.9 ne solution. All PCL fibers displayed strain-hardening behavior. On average, the stress increased with strain to the second power. Therefore, the larger extensibilities at higher ne also led to a more than double increase in fiber strength. Our results support the role of polymer entanglement in the mechanical properties of electrospun fiber at large strains.
Simultaneous Enhancement of the Mechanical Properties, Performance and Insensitivity of an Energetic Elastomeric Polyurethane Binder by Kinetically Grafting Reactive Spiranes
Authors: Ma Mingyang , Kwon Younghwan
Published: November 2023

A series of robust energetic polyurethane binders was developed by in situ grafting reactive spiranes to achieve the migration-resistant processing aid and compensate for the energy output. The reactive grafting spiranes (RGSs), bearing two highly ring-strained spiranes, were synthesized sequentially to provide a promising ring strain energy up to a maximum value of 290 kJ mol−1. The thermodynamic compatibility of the RGS with uncured glycidyl azido polymer (GAP) was studied quantitatively by analyzing the glass transition temperature of their blendings. The reactivity study of the catalyst-free click reaction with respect to spacer-dependent species was amplified by tracing the extent of the reaction and measuring the activation energy. The faster reactivity of propargyl species was evident from two experimental approaches, which were verified further by theoretical predictions. Interestingly, the energy gap difference in the frontier molecular orbitals agreed well with the difference in activation energy between the two types of spacer-dependent species. The mechanical and thermochemical enhancements of GAP-based polyurethane with RGS were basically gained from those highly ring-strained moieties.
Myo Transformer Signal Classification for an Anthropomorphic Robotic Hand
Authors: Núñez Montoya Bolivar , Valarezo Añazco Edwin , Guerrero Sara , Valarezo-Añazco Mauricio , Espin-Ramos Daniela , Jiménez Farfán Carlos
Published: November 2023

The evolution of anthropomorphic robotic hands (ARH) in recent years has been sizable, employing control techniques based on machine learning classifiers for myoelectric signal processing. This work introduces an innovative multi-channel bio-signal transformer (MuCBiT) for surface electromyography (EMG) signal recognition and classification. The proposed MuCBiT is an artificial neural network based on fully connected layers and transformer architecture. The MuCBiT recognizes and classifies EMG signals sensed from electrodes patched over the arm’s surface. The MuCBiT classifier was trained and validated using a collected dataset of four hand gestures across ten users. Despite the smaller size of the dataset, the MuCBiT achieved a prediction accuracy of 86.25%, outperforming traditional machine learning models and other transformer-based classifiers for EMG signal classification. This integrative transformer-based gesture recognition promises notable advancements for ARH development, underscoring prospective improvements in prosthetics and human–robot interaction.
On the Relation of Public Opinion and Religion: Theoretical Considerations
Authors: Hidas Zoltán
Published: November 2023

Facing the modern expectations about publicity and the high esteem of public opinion, it can be challenging to disclose the sources of these expectations. After sketching the origin of the idea and reality of publicity from the 18th century onward, practical and theoretical concerns about public opinion are discussed alongside the criticism of Walter Lippmann, evoking seminal conceptions of collectivity and of the crowd. It was the German philosopher Ferdinand Tönnies who, from a sociologically informed perspective, systematically analyzed the idea of public opinion. As a stakeholder of religious demands, public opinion is a metaphysical instance. Publicity seems to be socially centered around public intellectuals peculiarly legitimized by scientific knowledge, who have an immense influence on the shape of public opinion through social imagineries (Charles Taylor). The challenge of having a religious relationship with the world has changed due to the public, but self-transcendent need specific responsibilities even in modern circumstances.
Disentangling Trend Risk and Basis Risk with Functional Time Series
Authors: Liu Yanxin , Li Johnny Siu-Hang
Published: November 2023

In recent multi-population stochastic mortality models, one critical scientific issue is the vague distinction between trend risk and population basis risk. In particular, the cross- and auto-correlations between the innovations of the latent factors representing the common trend and the population-specific trends are often assumed to be non-existent, although they are possibly statistically significant. While it is theoretically possible to capture such correlations by treating the latent factors as a vector time series, the resulting model would contain a large number of parameters, which may in turn lead to robustness problems. In this paper, we address these issues by the use of the product–ratio model. Contrary to the prevalent assumption of non-existent correlations, the latent factors under the product–ratio model are approximately uncorrelated. This permits us to disentangle trend risk and population basis risk, thereby sparing us from the need to use a heavily parameterized vector time-series process. Compared to the augmented common factor model, our approach demonstrates improved robustness in terms of correlation structures and hedging performance, offering a new perspective on treating cross- and auto-correlations between latent factors in mortality modeling.
The Association of Perfluoroalkyl Substance Exposure and a Serum Liver Function Marker in Korean Adults
Authors: Yun Jisuk , Kwon Soon-Chan
Published: November 2023

Perfluoroalkyl substances (PFAS), widely used throughout industry and daily life, are currently one of the environmental pollutants garnering the most attention worldwide. Recently, environmental pollutants have had a high profile as one of the main causes of chronic liver disease, such as non-alcoholic fatty liver disease. Research on PFAS is actively underway. Although Korea has a remarkably high prevalence of chronic liver disease, and it continues to increase, only a few studies have revealed the relationship between PFAS and liver disease. In addition, regulations on PFAS in Korea are delayed compared to developed countries, such as Europe and the United States, and public interest is insufficient compared to others. Therefore, we would like to investigate the exposure of Koreans to PFAS in the blood and examine the relationship between these substances and markers of liver function (AST, ALT, and GGT). This study was based on the results of the Korean National Environmental Health Survey (KoNEHS) 2015–2017 (Cycle 3), and a total of 2961 subjects were selected. The concentration of PFAS in the blood of Korean adults was measured to be significantly higher based on the geometric mean compared to the results of recently investigated American adults based on the National Health and Nutrition Examination Survey (NHANES, 2017–2018). A multivariable linear regression analysis adjusted for age, sex, body mass index (BMI), smoking status, alcohol intake, and regular exercise was performed to examine changes in three liver function markers as the serum PFAS concentration increased. We found that some of the five PFAS (PFOA, PFOS, PFHxS, PFNA, and PFDeA) were significantly associated with increased liver enzymes. It is necessary to recognize the threat of PFAS to the human body and to discuss regulations and alternatives in earnest. Continuous follow-up studies are required through a well-designed cohort.
Pre-Clinical Safety and Immunogenicity Study of a Coronavirus Protein-Based Subunit Vaccine for COVID-19
Authors: Shorayeva Kamshat , Nakhanov Aziz , Nurpeisova Ainur , Chervyakova Olga , Jekebekov Kuanysh , Abay Zhandos , Assanzhanova Nurika , Sadikaliyeva Sandugash , Kalimolda Elina , Terebay Aibol , Moldagulova Sabina , Absatova Zharkinay , Tulendibayev Ali , Kopeyev Syrym , Nakhanova Gulnur , Issabek Aisha , Nurabayev Sergazy , Kerimbayev Aslan , Kutumbetov Lespek , Abduraimov Yergali , Kassenov Markhabat , Orynbayev Mukhit , Zakarya Kunsulu
Published: November 2023

Creating an effective and safe vaccine is critical to fighting the coronavirus infection successfully. Several types of COVID-19 vaccines exist, including inactivated, live attenuated, recombinant, synthetic peptide, virus-like particle-based, DNA and mRNA-based, and sub-unit vaccines containing purified immunogenic viral proteins. However, the scale and speed at which COVID-19 is spreading demonstrate a global public demand for an effective prophylaxis that must be supplied more. The developed products promise a bright future for SARS-CoV-2 prevention; however, evidence of safety and immunogenicity is mandatory before any vaccine can be produced. In this paper, we report on the results of our work examining the safety, toxicity, immunizing dose choice, and immunogenicity of QazCoVac-P, a Kazakhstan-made sub-unit vaccine for COVID-19. First, we looked into the product’s safety profile by assessing its pyrogenicity in vaccinated rabbit models and using the LAL (limulus amebocyte lysate) test. We examined the vaccine’s acute and sub-chronic toxicity on BALB/c mice and rats. The vaccine did not cause clinically significant toxicity-related changes or symptoms in our toxicity experiments. Finally, we performed a double immunization of mice, ferrets, Syrian hamsters, and rhesus macaques (Macaca mulatta). We used ELISA to measure antibody titers with the maximum mean geometric titer of antibodies in the animals’ blood sera totaling approximately 8 log2. The results of this and other studies warrant recommending the QazCoVac-P vaccine for clinical trials.
Recombinant Salmonella gallinarum (S. gallinarum) Vaccine Candidate Expressing Avian Pathogenic Escherichia coli Type I Fimbriae Provides Protections against APEC O78 and O161 Serogroups and S. gallinarum Infection
Authors: Dai Peng , Wu Hucong , Ding Guowei , Fan Juan , Li Yuhe , Li Shoujun , Bao Endong , Li Yajie , Gao Xiaolei , Li Huifang , Zhu Chunhong , Zhu Guoqiang
Published: November 2023

Avian pathogenic Escherichia coli (APEC) is one of the leading pathogens that cause devastating economic losses to the poultry industry. Type I fimbriae are essential adhesion factors of APEC, which can be targeted and developed as a vaccine candidate against multiple APEC serogroups due to their excellent immunogenicity and high homology. In this study, the recombinant strain SG102 was developed by expressing the APEC type I fimbriae gene cluster (fim) on the cell surface of an avirulent Salmonella gallinarum (S. gallinarum) vector strain using a chromosome-plasmid-balanced lethal system. The expression of APEC type I fimbriae was verified by erythrocyte hemagglutination assays and antigen-antibody agglutination tests. In vitro, the level of the SG102 strain adhering to leghorn male hepatoma (LMH) cells was significantly higher than that of the empty plasmid control strain, SG101. At two weeks after oral immunization, the SG102 strain remained detectable in the livers, spleens, and ceca of SG102-immunized chickens, while the SG101 strain was eliminated in SG101-immunized chickens. At 14 days after the secondary immunization with 5 × 109 CFU of the SG102 strain orally, highly antigen-specific humoral and mucosal immune responses against APEC type I fimbriae protein were detected in SG102-immunized chickens, with IgG and secretory IgA (sIgA) concentrations of 221.50 μg/mL and 1.68 μg/mL, respectively. The survival rates of SG102-immunized chickens were 65% (13/20) and 60% (12/20) after challenge with 50 LD50 doses of APEC virulent strains O78 and O161 serogroups, respectively. By contrast, 95% (19/20) and 100% (20/20) of SG101-immunized chickens died in challenge studies involving APEC O78 and O161 infections, respectively. In addition, the SG102 strain effectively provided protection against lethal challenges from the virulent S. gallinarum strain. These results demonstrate that the SG102 strain, which expresses APEC type I fimbriae, is a promising vaccine candidate against APEC O78 and O161 serogroups as well as S. gallinarum infections.
Assessing Impacts of Flood Diversion on the Ecosystem of Brackish-Water Lakes through Simulation-Optimization Model
Authors: Sedighkia Mahdi , Linhoss Anna , Mickle Paul
Published: November 2023

This study develops and evaluates a simulation-optimization approach to mitigate the environmental impacts of freshwater pulses in brackish-water lakes whilst maximizing flood diversion benefits. Lake Pontchartrain, located downstream of the Mississippi River, Mississippi, United States, is a brackish-water ecosystem threatened by reducing salinity concentrations due to freshwater pulses from the flood diversion project on the Mississippi River. An adaptive neuro-fuzzy-inference-system-based model was developed as a data-driven model for simulating salinity distribution at a representative station of Lake Pontchartrain. Then, the data-driven model was used as the simulator in the optimization system. Both single-objective and multi-objective particle swarm optimizations were used to find the optimal solutions. Results show that the data-driven model is robust at simulating the salinity time series in the brackish-water ecosystem of Lake Pontchartrain. The Nash–Sutcliffe efficiency index of the data-driven model between measured and modelled salinity is 0.85, which means the model is reliable for applying in further simulations. The proposed optimal solutions for the environmental management of the lake indicate that because of the magnitude of the volume of freshwater released, environmental impacts at this location cannot be optimized through varying the timing and volume of the releases. This work presents a novel contribution to science through developing an optimization framework for mitigating the impacts of flood management on changes in salinity in brackish-water systems.
Cultura visual, educação e identidade: o documentário como ferramenta didática
Authors: Rodrigues Vanessa Ionara , De Souza Jorge Andrade , Ramos Valéria Oliveira Borges
Published: November 2023

O presente trabalho está inserido na área de Educação e tem no cerne do seu objeto uma análise voltada para a relevância e contribuições da Cultura Visual, considerando que vivemos em sociedades da Informação e do Consumo onde, cada vez mais, os avanços tecnológicos demandam que as práticas educativas e didáticas se reinventem, de modo a viabilizar aprendizagens significativas. O intuito é o de traçar um debate apontando possibilidades, fragilidades e potencialidades do uso de feramentas audiovisuais em espaços escolares  e não escolares de aprendizagem/formação, pensando em aspectos como as construções identitárias de estudantes do ensino regular e de pessoas organizadas em grupos sociais em geral, visando expandir reflexões e iniciativas que reafirmem o caráter crítico, multiplicador e transformador que deve ser característico de todo e qualquer processo formativo.
Classic Kaposi Sarcoma: An Unusual Presentation in an HIV-Negative Man
Authors: Eslami Mahsa , Alizadeh Sanaz , Alavi Faezeh , Safari Sina
Published: November 2023

Kaposi sarcoma (KS) is a type of cancer that develops in blood vessels of the mouth, lymph nodes, and lungs. Our case report is about a 66-year-old man with purple patches and plaques, as well as nodules distributed in the legs and arms. Biopsy of the skin lesions showed angiomatous proliferation of small vessels with mild perivascular lymphocytic infiltration with plasma cells. We started chemotherapy for this disseminated form of Kaposi sarcoma.
Ischemic stroke following COVID-19 vaccination
Authors: Masoudian Nooshin , Kakovan Maryam , Ghorbani Shirkouhi Samaneh , Ehsani Fatemeh , Andalib Sasan
Published: November 2023

Following the coronavirus disease 2019 (COVID-19) vaccination, complications are expected. In this regard, coagulopathy after COVID-19 vaccination has been reported. Here, we report a rare case of ischemic stroke subsequent to receiving the Beijing Bio-Institute of Biological Products - Coronavirus (BBIBP-CorV) vaccine (Sinopharm). Ten days after receiving the first dose of the BBIBP-CorV vaccine, a 76-year-old woman showed right central hemifacial weakness, balance disorder, and right hemisensory involvement with normal muscle force. Although the magnetic resonance imaging assessment revealed an acute lacunar stroke in her left thalamus, laboratory findings were normal. Based on our report, ischemic stroke may be a post-complication of BBIBP- CorV vaccination. However, further studies are needed to confirm this finding.
EXAME PAPANICOLAU COMO FERRAMENTA DE PREVENÇÃO DO CÂNCER CÉRVICO UTERINO NO BRASIL: REVISÃO DE LITERATURA
Authors: EDUARDA SILVA ASSUNÇÃO MARIA , AMABILLE FERREIRA CHAGAS LAILA , BERNARDO DOS SANTOS VICTOR , VIEIRA QUEIROZ LABRE LUCIANA
Published: November 2023

Cervical cancer is caused by a persistent infection with oncogenic subtypes of the human papillomavirus (HPV) and is one of the most common types of cancer among women in Brazil. The disease has the characteristic of progressing slowly, with no symptoms in the primary phase. The disease is diagnosed through the Pap smear, where cells are collected from the cervix to detect abnormalities. This article aims to identify and recognize the importance of the Pap smear as a tool for preventing cervical cancer in Brazil in the different female age groups, taking into account social, regional, cultural and economic factors. An exploratory literature study was carried out in the category of a bibliographic review, using the databases of the National Cancer Institute (INCA), Scientific Electronic Library Online (Scielo), Latin American and Caribbean Literature in Health Sciences (Lilacs), Google Scholar and USP's VHL Portal. The majority of the studies showed that there is low adherence among women to the Pap smear as a preventive tool. The discomfort, lack of information about the test, periodicity and its importance, low schooling, low income and religion are the main factors related to not having the test. The Pap smear is an important tool for the prevention of cervical cancer, because when it is carried out periodically it is able to detect lesions early, and consequently start treatment and cure the disease.
ANÁLISE DA SEGURANÇA NA TRANSMISSÃO DE DADOS/SEGURANÇA DA INFORMAÇÃO
Authors: HENRIQUE PIZZAIA FABIO , MIRELLA FARINA RENATA , FLORIAN FABIANA
Published: November 2023

This article aims to carry out an analysis about information security, areas that specifically deal with the protection of one or more sets of data, in the sense of preserving information and its respective values within a company, or for an individual in particular. Within this context, it is important to remember that the concept of data security or information security is inserted within a larger context, which is computer security, that is, the security of the systems themselves. Ensuring information security in a company, for example, is extremely necessary within a highly competitive market. It is worth emphasizing that information security works based on three tangents, which are confidentiality (where access to data is limited by permissions); integrity (the guarantee of the veracity of information); availability (access to information easily)
PENDIDIKAN MASYARAKAT BERBASIS WAWASAN KEBANGSAAN: UPAYA PENANAMAN NILAI-NILAI EDUCATION FOR SUSTAINABLE DEVELOPMENT DI KAMPUNG PANCASILA
Authors: Hastangka Hastangka , Rochwidowati Novia Sinta , Sa’adah Annas Fitria
Published: November 2023

Masyarakat menjadi bagian penting dalam proses pembentukan karakter dan nilai nilai pembangunan yang berkelanjutan. Masyarakat menjadi pusat dinamika kehidupan. Berbagai persoalan yang terjadi mulai dari masalah lingkungan, masalah lunturnya budaya dan kearifan bangsa, dan persoalan kesenjangan ekonomi terjadi pada level masyarakat. Persoalan yang mendasar yang dihadapi masyarakat saat ini ialah persoalan yang secara umum menyangkut kehidupan sosial, ekonomi, dan lingkungan. Ketiga persoalan ini menjadi perhatian dari seluruh Negara untuk dapat dicarikan solusi yang memadai bagaimana masyarakat dapat berdaya dan memiliki kemampuan untuk menjawab persoalan pembangunan sosial tersebut. Kajian ini memfokuskan pada kampung Pancasila karena kampung ini memiliki persoalan identitas, jati diri, dan pembangunan yang berkelanjutan. Tujuan dari kajian ini ialah untuk mendeskripsikan tentang bagaimana pola pendidikan masyarakat dalam menanamkan nilai nilai education for sustainable Development dan bagaimana profil modal sosial yang dimiliki masyarakat terkait wawasan kebangsaan. Studi ini merupakan bagian dari kegiatan pengabdian kepada masyarakat yang dilakukan di Kampung Pancasila, Gowongan Kidul, Kota Yogyakarta pada tahun 2021. Metode yang digunakan dalam kajian ini menggunakan pendekatan mix methods, kerangka konseptual yang digunakan menggunakan kerangka konseptual filsafat pendidikan kemasyarakatan. Data diperoleh melalui observasi, survei, kajian teoritis atas sumber bacaan dari jurnal, buku, wawancara, dan FGD. Analisis yang digunakan menggunakan pendekatan analisis interpretasi dan fenomenologi. Hasil kajian ini menunjukkan bahwa pendidikan masyarakat menjadi upaya penting untuk membangun kesadaran masyarakat akan pentingnya pembangunan yang berkelanjutan. Keberhasilan program pembangunan yang berkelanjutan juga perlu didukung modal sosial yang memadai dan peran tokoh masyarakat sebagai penggerak anggota yang lain.
PENERAPAN TEKNOLOGI PENGERING UBI KAYU UNTUK PAKAN TERNAK PADA KELOMPOK TANI BERINGIN MAKMUR KOTA PEKANBARU
Authors: Novchi Raja Widya , Hanafi Khusnul , Haris Aidil , Amalia Asrinda , . Hardin
Published: November 2023

Kelurahan Sungaisibam terletak di Kota Pekanbaru Provinsi Riau, merupakan salah satukelurahan yang mengandalkan hasil pertanian berupa ubi kayu. Kawasan ini terkenal denganhasil ubi kayu dan terdapat beberapa kelompok tani didalamnya, salah satunya adalahkelompok tani beringin makmur. Tujuan dibuatnya pengabdian berawal dari pelaksanaanKuliah Kerja Nyata (KKN) Universitas Muhammadiyah. Ketua kelompok tani beringinmakmur meminta bantuan menyelesaikan persoalan terkait dengan banyaknya bahan bakuubi kayu namun terkendala dari segi pengolahan, proses pengeringan dan pemasaran hinggapada akhirnya pengabdi melahirkan sebuah ide untuk membuat sebuah teknologi yangdiperuntukkan bagi petani ubi kayu. Permasalahan terbesarnya yaitu kelompok tani BeringinMakmur masih mengandalkan cahaya matahari untuk proses pengeringan ubi yang sudah dicincang. Tentunya ini memerlukan waktu yang cukup lama apalagi jika cuaca kurangmendukung dalam proses pengeringan maka dapat menimbulkan kerugian yang besar sepertimunculnya jamur pada permukaan ubi kayu. Maka dari itu tim pengabdi memberikan 1 unitteknologi tepat guna berupa alat pengering ubi kayu yang diperuntukkan untuk membuatgaplek/pakan ternak. Hal tersebut sangat membantu kelompok tani karena dari hasilobservasi dan wawancara tim pengabdi sebelumnya, kelompok tani mengaku hanyamengandalkan terik matahari dan proses pengeringan bisa memakan waktu 3-7 hari. Pihakyang terlibat dalam pengabdian ini yaitu mitra, ketua pengabdian, anggota pengabdian,dosen teknik mesin, dosen komunikasi digital dan empat orang mahasiswa. Kegiatanpengabdian telah dilakukan dari bulan Mei-Desember 2021 meliputi survey lokasi,kerjasama dengan mitra, workshop digital marketing, pengenalan, pendampingan danpemberian 1 unit teknologi dehidrator, publikasi kegiatan pengabdian di media online sertamengunggah video kegiatan pengabdian pada channel youtube.
HUBUNGAN ANTARA SENSE OF HUMOR GURU DAN MINAT BELAJAR MATEMATIKA SISWA DENGAN KEMAMPUAN PEMAHAMAN MATEMATIS
Authors: Oktaviani Fara Nenti , Firmansyah Dani
Published: November 2023

Tujuan dari penelitian ini yaitu untuk mengetahui hubungan antara sense of humor guru dan minat belajar matematika siswa dengan kemampuan pemahaman matematis siswa. Penelitian ini merupakan penelitian kuantitatif dengan metode expost facto. Populasi sekaligus sampel pada penelitian ini yaitu seluruh siswa kelas VIII MTs. Al-Muhajirin Bantargebang sebanyak 23 orang dengan teknik pengambilan sampel adalah sampel jenuh. Teknik pengumpulan data dilakukan dengan angket dan tes. Berdasarkan hasil analisis data dengan menggunakan korelasi kendall tau, dapat diambil kesimpulan bahwa terdapat hubungan yang signifikan antara sense of humor guru dengan kemampuan pemahaman matematis siswa dengan  dan kekuatan hubungan antar variabel yang ditunjukkan oleh koefisien determinasi sebesar 30%. Kemudian terdapat hubungan yang signifikan antara minat belajar matematika siswa dengan kemampuan pemahaman matematis siswa dengan  dan kekuatan hubungan antar variabel yang ditunjukkan oleh koefisien determinasi sebesar 34%. Kemudian terdapat hubungan yang signifikan antara sense of humor guru dan minat belajar matematika siswa dengan kemampuan pemahaman matematis siswa dengan  dan kekuatan hubungan antar variabel yang ditunjukkan oleh koefisien determinasi sebesar 56%. Sedangkan sumbangan sisa persentase lainnya diperoleh dari faktor lain yang belum diketahui.
MINAT BELAJAR MATEMATIKA PADA SISWA SEKOLAH MENENGAH PERTAMA DI KARAWANG
Authors: Widiyanti Winda , Haerudin Haerudin
Published: November 2023

Penelitian ini bertujuan untuk menganalisis minat belajar matematika siswa Sekolah Menengah Pertama (SMP) di Kabupaten Karawang. Subjek penelitian ini yaitu sebanyak 37 siswa. Metode yang digunakan adalah metode deskriptif. Instrumen dalam penelitian ini ialah instrumen non-tes yang berupa angket dengan 34 pernyataan yang didalamnya memuat pernyataan positif dan pernyataan negatif. Instrumen angket yang digunakan berdasarkan 4 indikator minat belajar siswa yaitu perasaan senang, perhatian, ketertarikan, dan ketertiban sistem. Hasil penelitian menyatakan bahwa hampir seluruhnya siswa memiliki perasaan senang dalam pembelajaran matematika dan juga hampir seluruhnya siswa menunjukkan perhatian saat belajar matematika. Rata-rata persentase data angket secara keseluruhan didapatkan sebesar 40% yang berarti bahwa hampir setengahnya siswa SMP pada salah satu sekolah di Kabupaten Karawang memiliki minat belajar matematika.
CÓMO SELECCIONAR OBRAS PARA PRIMEROS LECTORES (0-3) DESDE LA VISIÓN DE MAESTRAS MEDIADORAS
Authors: Rivera Jurado Paula , Bericua Gordillo Ana , Sánchez Rodríguez Susana
Published: November 2023

Este trabajo explora y describe criterios de selección de obras para una educación literaria en el ciclo 0-3 de Educación Infantil. Se han analizado los testimonios de cuatro maestras que cuentan con más de 10 años de experiencia en escuelas infantiles (0-3) para quienes es central la labor de mediación en la educación literaria de las primeras edades. Los datos han sido recogidos mediante entrevistas semiestructuradas y analizados con el software QDAMiner. El análisis se orientó al significado dando lugar a siete subcategorías en torno a cómo seleccionar obras para una educación literaria temprana. Los resultados indican que los criterios de selección de las maestras ponen de relieve las propiedades físicas y visuales del libro infantil, las cualidades del texto, los temas e intereses del niño, la experiencia docente y la práctica en el aula. Estos datos pueden ayudar a sistematizar criterios de selección útil para mediadores y también a fortalecer la formación inicial del profesorado de Educación Infantil desde el conocimiento que docentes con experiencia atesoran sobre el libro para estas edades.
Strategi Coping Stress dalam Menangani Stres Kerja Geriatric Nursing di PPSLU Mappakasunggu Kota Parepare
Authors: Saleh Adnan Achiruddin , Amelia Nur Resky
Published: November 2023

This study aims to determine the effect of dialog reading methods and improve language skills of early childhood. This study used a single subject research with A-B design. The research subjects were students of Kindergarten A PAUD Anak Ceria Surabaya with information about the development of language skills which were known based on observations, interviews, language proficiency checklists, and formal tests regarding language development of children aged 4 years. Data obtained through analysis of the subject's language skills in baseline (A) with intervention conditions (B) and analysis between baseline (A) and intervention (B). The results showed an increase in children's language skills from 34.3% in baseline to 65.7% in the intervention. The conclusion from this age study shows that the dialogue reading method can improve children's language skills. The implication of this research is that the dialogue reading method can stimulate the improvement of children's language skills as early as possible and for children who have developed language development, especially expressive language. The dilaog reading method can be applied at home and at school.
WHEN SHE GOT WEAKER BY THE WEEK: AN INTERESTING CASE OF IMMUNE MEDIATED MYOPATHY
Authors: S Srividhya. , Nandakumar V. , Jawahar M.
Published: November 2023

Immune mediated necrotizing myositis (IMNM) is classied under the umbrella of immune mediated myopathies. It is an important subgroup
because of the specic antibodies associated with it, and the clinical signicance in terms of disease progression and treatment response which is
unique for each antibody. Here, we report a case of a 50 years old female who presented with severe proximal weakness of lower limbs, myalgia and
hyporeexia. Examination also revealed ail symmetrical weakness, with generalised muscle wasting and scapular winging. Muscle tenderness
was present on palpation. Her creatine kinase levels were over the roof, nearly more than 20-fold elevated. Electromyography showed myopathic
changes and hence she was tested for myositis, and found to be positive for anti-SRP antibodies. She required adjuvant immunosuppression in
addition to steroids and nally improved with Rituximab. The importance of a timely diagnosis of IMNM cannot be more emphasized as it bears
major consequences for treatment response and progression.
A PROSPECTIVE STUDY ON EFFECT OF VITAMIN D3 LEVEL ON BENIGN PROSTATIC HYPERPLASIA: OUR INSTITUTION EXPERIENCE
Authors: Saraswathi S. , Mohamad Ali Sayyad , Kirane Kshitij , Kireeti Gollamandala , Sabrena M.
Published: November 2023

Aim &Objectives: To study the effect of vitamin d3 level on benign prostatic hyperplasia patients in our institution. We also did the following
parameters work up in the study population .Vitamin d3 level, prostate volume by TRUS,S.PSA, uroowmetry and IPSS SCORE. Materials and
Methods: We conducted prospective observational case study from October 2022 to August 2023 in 150 BPH cases in Department of Urology,
Government Stanley medical college. Study population > 50 YEARS with LUTS divided into two groups with normal vitamin d3 and vitamin d3
decient . Routine clinical examination ,prostate USG, TRUS, labaratory tests were performed. Inclusion criteria: age > 50 years; LUTS symptoms
Exclusion criteria: Nodular prostate, Elevated BPH,other malignancies,other causes for LUTS. Results: The mean age of the participiants was 63
(50-77) years . GROUPI: 47 (31.4)% GROUPII: 103 ( 68.6%). The mean prostate volume was higher in group II:44.7cc(31-65cc), the mean S PSA
was higher in group II: 3.28ng/ml.,IPSS score was higher in group II :18 . Conclusion: The results of our study support the effect of vitamin d3 in
reducing prostate volume , S PSAlevel,and BPH symptom improvement.
Inovasi Manajemen Kinerja Guru dalam Meningkatkan Mutu Pendidikan di MI. Kahasri Kota Probolinggo
Authors: Priyanto Suef , Hidayah Nurul
Published: November 2023

Education is one of the pillars of a country's development. Teachers as central figures in the education system have a very important role in improving the quality of education. Innovation in teacher performance management is the key to improving the quality of education. This research examines effective innovations in teacher performance management to improve the quality of education. This research uses a qualitative research method with a case study approach at Madrasah Ibtidaiya Kahasiri, Probolinggo City. Data was collected through interviews with teachers, classroom observations, and analysis of documents related to teacher performance management. This study shows that effective innovation in teacher performance management includes several main aspects. First, inclusive and collaborative leadership development helps create a positive work environment. Leadership that understands and supports teachers' needs and supports their professional development plays a key role in increasing teacher morale and motivation. Second, teacher empowerment through training and skills development aims to improve pedagogical competence and classroom management skills. Third, the use of information and communication technology (ICT) in education and teacher performance management can increase the efficiency and effectiveness of the learning process. The results of this research indicate that effective innovation in teacher performance management requires collaboration between school principals, teachers and other stakeholders. Creating a positive work environment, empowering teachers, and using technology wisely can significantly improve the quality of education. Therefore, education stakeholders are expected to adopt these innovations to improve the quality of education and provide a better future for future generations.