bluuebunny/crossref_metadata_2025 huggingface dataset:
Risk Management Considerations and Multiple Responsibilities in Medical Pharmaceutical Practice
Authors: Emin Cadar , Laurentiu Tomescu Cazar , Maria Pesterau Ana-
Published: December 2024

In the health field, risk assessment of health damage is a basic component in the control and maintenance of human health. Risk management is defined as the technique of assessing and preventing accidental losses through insurance, and safety measures by making the right decisions and ensuring accountability. The responsibility of those in the medical-pharmaceutical field is permanent and multiple, on several levels, and named as follows: professional responsibility towards the patient, legal responsibility, administrative responsibility, economic responsibility, and social responsibility. Accountability in decisions is ongoing all the time and is a constant, daily, and multi-layered activity. The double responsibility of the doctor and the pharmacist is very important: to the patient and to the community. The society holds physicians accountable for the high cost of health care. Public health programs, warn that the rate of increase in medical costs is growing faster than national income. Still, patients, who are becoming more and more informed about medical issues - are also demanding more diagnostic procedures, more drugs, more medical care, and more hospitalizations.
On-line OCHEM Multi Task Model for Solubility and Lipophilicity Prediction of Platinum Complexes
Authors: Mousa Nesma , P. Varbanov Hristo , Kaipanchery Vidya , Gabano Elisabetta , Ravera Mauro , A. Toropov Andrey , Charochkina Larisa , Menezes Filipe , Godin Guillaume , V. Tetko Igor
Published: December 2024

Predicting the solubility of platinum(II, IV) complexes is essential to the process of prioritizing potential anticancer candidates in drug discovery. This study presents the first publicly available on-line model for predicting the solubility of platinum complexes, addressing the current scarcity of literature and absence of models in this regard. Using a time-split dataset, the consensus model that we developed had a Root Mean Squared Error (RMSE) of 0.62 through 5-cross-validation on a training set of 284 historical compounds (solubility data reported prior to 2017). However, the RMSE increased to 0.86 when applied to a prospective test set of 108 compounds measured after 2017. Further analysis of the high prediction errors revealed that these inaccuracies are primarily attributed to the underrepresentation of novel chemical scaffolds–mainly Pt(IV) derivatives, in the training sets. For instance, a series of eight phenanthroline-containing compounds, not covered by the training set’s chemical space, had an RMSE of 1.3. When the model was redeveloped using a combined dataset, the RMSE of this series significantly decreased to 0.34 under the same validation protocol. Additionally, we developed an interpretable linear model to identify structural features and functional groups that influence the solubility of platinum complexes. We further validated the correlation between solubility and lipophilicity, consistent with the Yalkowsky General Solubility Equation. Building on these insights, we developed a final multitask model that simultaneously predicts solubility and lipophilicity as two endpoints with RMSE = 0.62 and 0.44, respectively. The data and final developed model is available at https://ochem.eu/article/31.
Electric double layer structure of water-in-salt electrolyte in a porous carbon electrode elaborated with Raman spectroscopy and electrochemical methods
Authors: Islam Tauhidul , Fitzek Harald , Gollas Bernhard , Abbas Qamar
Published: December 2024

Understanding the interplay between ion association, desolvation, and electric double layer (EDL) structure is crucial for designing high-performance energy storage devices with concentrated electrolytes. However, these dynamics in water-in-salt electrolytes within the nanopores of carbon electrodes are not fully understood. This study explores the ion association in water-in-salt LiTFSI electrolyte in more detail, classifying various ion pairs as a function of concentration. Based on Raman spectroscopy data of electrolyte and electrochemical investigations on non-porous electrodes, modification in the classical Gouy-Chapman-Stern (GCS) model has been proposed by incorporating ionicity to estimate Debye length. The modified model shows a sharp Debye length decrease as the concentration rises from 1 to 10 mol∙kg⁻¹ but an increase beyond 10 mol∙kg⁻¹ due to ion pairing. The modified model accurately reflects differential and experimental EDL capacitance values obtained from cyclic voltammetry and electrochemical impedance spectroscopy. The data obtained for non-porous electrodes was adjusted by dividing it with the MacMullin number of the carbon electrode to estimate the Debye length in pores. Further, introducing the MacMullin number into the Stokes-Einstein equation enabled the estimation of ionic radii within pores, which was subsequently utilized to calculate extent of ion desolvation/dehydration in micro- and mesopores. The concentration-dependent ionic association governs the Debye length trends in pores, which correlate with confined ionic radii, ion desolvation, and resulting EDL charging dynamics. Our findings highlight 5 mol∙kg⁻¹ LiTFSI as optimal for faster charging rates and 10 mol∙kg⁻¹ for higher energy density, providing critical insights for developing efficient electrolytes and porous carbon electrodes.
Deciphering Electrocatalytic Activity in Cu Nanoclusters: Interplay between Structural Confinement and Ligands Environment
Authors: Biswas Sourav , Shingyouchi Yamato , Kamiyama Maho , Jena Milan Kumar , Ogami Masaki , Kawawaki Tokuhisa , Pathak Biswarup , Negishi Yuichi
Published: December 2024

Ligand-protected copper nanoclusters (Cu NCs) with atomic precision have emerged rapidly due to their fascinating structural architectures and versatile catalytic properties, making them ideal for investigating structure–activity relationships. Despite their potential, challenges such as stability issues and limited structural diversity have restricted deeper exploration. In this study, three distinct Cu NCs were synthesized using a one-pot reduction strategy by carefully modifying reaction conditions. Intriguingly, the same p-toluenethiol ligand produced two different geometries, while varying ligand with m-aminobenzethiol—yielded clusters with similar geometric architectures. These NCs were evaluated for electrocatalytic CO2 reduction, uncovering diverse catalytic activities and product selectivity. Experimental and theoretical analyses revealed that the interplay between the core structure confinement and surface ligand environment governs their catalytic behavior. Specifically, the Cu11 NC with p-toluenethiol ligand exhibited selectivity toward HCOOH production (FEHCOOH~45% at -1.2 V vs. RHE), whereas substituting p-toluenethiol with m-aminobenzethiol shifted the selectivity to the competitive side reaction (FEH2~82% at -1.2 V vs. RHE). Conversely, altering the geometry of Cu18 NC while retaining the p-toluenethiol ligand decreased such selectivity (FEHCOOH~35% at -1.2 V vs. RHE). These findings highlight the tunability of Cu NCs for tailored catalytic applications through precise control of their structure and surface chemistry.
Application of amber suppression to study the role of Tyr M210 in electron transfer in R. sphaeroides photosynthetic reaction centers
Authors: Tran Khoi , Faries Kaitlyn , Magdaong Nikki , Mathews Irimpan , Weaver Jared , Kirsh Jacob , Holten Dewey , Kirmaier Christine , Boxer Steven
Published: December 2024

The initial light-induced electron transfer (ET) steps in the bacterial photosynthetic reaction center (RC) have been extensively studied and provide a paradigm for connecting structure and function. Although RCs have local pseudo-C2 symmetry, ET only occurs along the A branch of chromophores. Tyrosine M210 is a key symmetry-breaking residue adjacent to bacteriochlorophyll BA that bridges primary electron donor P and bacteriopheophytin acceptor HA. We used amber suppression to incorporate phenylalanine variants with different electron-withdrawing/donating capabilities at position M210. X-ray data generally reveal no appreciable structural changes due to the mutations. P* decay and P+HA formation are multi-exponential (~2-9, ~10-60, and ~100-300 ps) and temperature dependent. The 1020 nm transient-absorption band of P+BA is barely resolved for a few variants at 295 K and for none at 77 K. The results indicate a change from two-step ET for wild-type RCs to dominance of one-step superexchange ET for the mutants. Resonance Stark spectroscopy reveals that the free energy of P+BA changes by -57 to +66 meV among the phenylalanine variants. Because P+BA apparently lies above P* in all phenylalanine variants, the perturbations primarily affect the energy denominator for superexchange mixing. The findings deepen insight into primary ET in the bacterial RC.
Energy-Activated and Diversifiable Aryne Precursors from Carboxylic Acids
Authors: Seong Chris , Kargbo Sallu , Yu Chia-Ling , Gibney Daniel , Boyn Jan-Niklas , Roberts Courtney
Published: December 2024

Densely substituted arene rings are ubiquitous in pharmaceuticals and agrochemicals which support human health and wellbeing. Arynes–a triple bond in a benzene ring–are an intriguing solution to the problem of generating decorated arenes. State-of-the-art aryne precursors are plagued by two issues: 1) the additives required for activation are incompatible with many desirable functional groups intrinsic to the aryne itself as well as the coupling partners which limits the scope, and 2) derivatization of the precursors requires lengthy linear sequences often using harsh conditions rendering them impractical for discovery chemists. Here, we show the design of an aryne precursor made in a single step from a commercially available carboxylic acid and then derivatized in a single SNAr step. Unprecedented aryne activation proceeds using blue light or mild heat, avoiding the use of additives. The model system for this precursor incorporates an ortho-amino group in the final stage because anilines are found in 40% of medicinal chemistry patents and are highly underrepresented in aryne methodology. These precursors have the potential to supersede existing precursors and enable broad access to this desirable synthon.
Day-Level Long Persistent Luminescence in Purely Organic Polymers via Cascade Hole Trap Mechanism
Authors: Chen Wei-Guang , Chen Zhi-Jian , Wang Yan , Zhuang Yan-Fang , Wang Lu-Yu , Lv Yi-Fan , Chang Jing , wang yong , Xiao Yin , Chen Yu
Published: December 2024

In recent years, organic long persistent luminescence (OLPL) materials have made significant progress in achieving hour-level OLPL through the charge-separation mechanism in host-guest composites. However, it remains a considerable challenge for OLPL materials to achieve such performance using commonly available, cost-effective optoelectronic-inert polymers as the host component. In this work, electron-deficient naphthalenediimide derivatives are utilized as guest molecules, which are dispersed into various polymers, achieving hour-level OLPL for the first time in widely used, low-cost optoelectronic-inert hosts, such as poly(methyl methacrylate) (PMMA), poly(L-lactic acid) (PLLA), poly(vinyl acetate) (PVAc), and polystyrene (PS). By combining commercially available PMMA with polycarbonate (PC), an unprecedented day-level OLPL phenomenon is observed. A cascade polymer hole trap mechanism is proposed to elucidate this exceptional OLPL performance. Additionally, these materials can be applied not only for large-area fabrication and nighttime illumination but also for stable emission in diverse extreme environments, as well as for multi-layer information encryption. This innovation opens new possibilities for OLPL materials to potentially replace conventional inorganic materials in future applications.
Hetero[3.1.1]propellanes
Authors: Revie Rebecca , Dasgupta Ayan , Biddick Yasmine , Christensen Kirsten , Smith Russell , Anderson Edward
Published: December 2024

[n.1.1]Propellanes are molecules featuring a carbon-carbon bond to which three rings are fused, two being cyclopropanes. [1.1.1] and [3.1.1]propellane are key precursors to small-ring bridged bicyclic hydrocarbons, motifs that have emerged as important building blocks in contemporary drug design. Due to their rigid frameworks and well-defined substituent vectors, these bicyclic hydrocarbons can serve as bioisosteres for disubstituted benzene rings, exhibiting improved metabolic stability compared to their aromatic parents, while also bringing benefits to solubility and other physicochemical properties. Unknown to date are [n.1.1]propellanes featuring heterocyclic rings, molecules that could enable the direct and rapid synthesis of a wide diversity of bridged bicyclic heterocycles, which should exhibit superior physicochemical profiles compared to their carbocyclic analogues while also introducing additional functionality for potential interactions with molecular targets. Here we report the unified synthesis of a family of heterocyclic [3.1.1]propellanes featuring oxygen, nitrogen and sulfur heteroatoms in the three-carbon bridge. The approaches we developed are necessarily distinct from the established route to carbocyclic propellanes, and utilise a common precursor that is conveniently assembled on multigram scale via a rhodium-catalysed cyclopropanation. We found that these hetero[3.1.1]propellanes are stable towards isolation and storage, but amenable to a range of radical ring-opening reactions, leading to bridgehead-disubstituted hetero-bicyclo[3.1.1]heptanes that cannot be accessed using alternative methods. Given the importance of heterocyclic scaffolds in pharmaceutical design, and the ever-growing popularity of rigid small ring building blocks, we expect these unprecedented hetero-propellanes will be of exceptional utility in drug discovery programmes
Physics-assisted machine learning for slurry drying simulation in manufacturing process of battery electrodes: A hybrid time-dependent VGG16-DEM model
Authors: Galvez-Aranda Diego Eduardo , Fernandez Francisco , Franco Alejandro A.
Published: December 2024

In this study, we present a hybrid Physics-Assisted Machine Learning (PAML) model that integrates Deep Learning (DL) techniques with the classical Discrete Element Method (DEM) to simulate the slurry drying during a lithium ion battery electrode manufacturing process. This model predicts the microstructure evolution leading to the formation of the electrode, as a time-series along the drying process. The hybrid approach consists in performing a certain amount of DEM simulation steps, n_DEM, after every DL prediction, mitigating the risk of unphysical predictions, like overlapping particles. Our PAML model was rigorously tested by evaluating different functional metrics of the predicted electrodes, including density, porosity, tortuosity factor, and radial distribution function. We conducted an in-depth analysis of performance versus accuracy, particularly focusing on the impact of the n_DEM hyperparameter, which represents the number of DEM steps executed between two subsequent DL predictions. Despite the model being trained on a specific formulation (96 % of Active Material, AM, and 4 % of Carbon Binder Domain, CBD), it demonstrated exceptional generalization capability when used to extrapolate to a different formulation (94 % AM and 6 % CBD). This adaptability highlights the robustness of our PAML hybrid approach. Furthermore, the integration of DL significantly reduced the computational cost versus the original DEM model simulation, decreasing the calculation time from 615 minutes to 36 min for the whole slurry drying simulation process. Our findings underscore the potential of combining ML with traditional simulation methods to enhance efficiency and accuracy in the field of electrode manufacturing.
Self-Directed Learning for the Students of the Allied Health Sciences
Authors: Archana Bhat Dr.
Published: December 2024

None
Effectiveness of a Faculty Development Programme on Essential Teaching Skills for Allied Health Sciences Educators
Authors: A R Shivashankara , Bhat Archana , K R Nagesh , D S Maitreyee , Shastry Neetha , Fernandes Hilda
Published: December 2024

Background There is a need to use innovative teaching-learning methods to promote motivation and learning among students. Students of allied health sciences AHS generally have a difficulty in understanding medical terminologies and concepts of various subjects taught to them. The faculty of AHS need to develop skills to use innovative methods to promote studentsrsquo learning. There is paucity of research on effectiveness of faculty development programs for AHS.Objectives The present study aimed to assess the effectiveness of a training program on ldquoessential teaching skillsrdquo for the AHS educators.Methods A one day training on teaching and assessment skills was conducted for twenty six faculties of AHS. Qualified faculties from medical education unit of medical college conducted the training on know the learners teaching methods assessment methods motivating students and self-directed learning. Effect of training on learning was assessed by pre-test and post-test knowledge questionnaire. The perceptions of participants were collected.Results The post-test knowledge score was significantly higher than pre-test score P.000. Interactive nature of the training time management and motivation to use learner-centric strategies were appreciated by the AHS educators. The educators expressed favourable perceptions of the training which enhanced their confidence in effective teaching skills imparted knowledge on innovative teaching and assessment methods and improved their confidence in classroom management.Conclusion The interactive training of AHS faculties significantly improved their knowledge of teaching and assessment skills and received favourable perceptions on its effectiveness. Periodic training of teachers is essential to enhance their teaching abilities and to impart quality education to students.
A Review on Immediate Implant Placement in Fresh Extraction Sockets
Authors: V Deepthi , Raveendran Amar , K Ankitha , Abdul Rahman Nadeem , EP Naveen , V Indu
Published: December 2024

Implant-retained prostheses are increasingly in demand due to the rising elderly population and the associated increase in edentulousness. Dental implants offer a number of benefits over traditional tooth-borne fixed prostheses. However patients may choose not to pursue implant-based treatment due to factors such as treatment duration the requirement for additional surgical procedures and the requirement for prolonged periods of temporization. In such cases immediate implants have proven to be a predictable therapeutic option.
Rare Gingival Manifestation of Primary Tuberculosis - A Case Report
Authors: Singh Akanksha , Singh Rika , G Shiva Manjunath R , Singh Pushpendra
Published: December 2024

Tuberculosis a granulomatous infectious disease remains a significant cause of mortality in underdeveloped regions. Primary gingival tuberculosis is an exceedingly rare and often overlooked condition. Oral lesions in such cases typically originate from tuberculosis infections elsewhere in the body and may manifest as ulcers nodules or raised fissures. This report highlights a case of primary gingival tuberculosis presenting as treatment-resistant gingivitis. The diagnosis was confirmed through histopathological examination and the gingivitis resolved following anti-tubercular therapy. The case underscores the importance of considering tuberculosis in the differential diagnosis of gingival conditions and emphasizes the role of clinicians in facilitating early detection especially given the recent rise in tuberculosis incidence.
A Prospective Cohort Study of Diagnosed Meniere’s Disease / Tinnitus Cases, Evaluated with Digital Occlusion Analyzer and Treated with Disclusion Time Reduction Therapy
Authors: Thumati Prafulla , P Thumati Roshan , P Thumati Prajwal , D Rakshita
Published: December 2024

Objective Menierersquos Disease MD and tinnitus are challenging to diagnose and treat. This study aimed to evaluate the effect of Disclusion Reduction Therapy DTR on Menierersquos disease patients testing the null hypothesis that occlusal corrections will not significantly improve tinnitus symptoms.Methods Fifty patients with tinnitus diagnosed by ENT specialists were referred for dental evaluation. Health histories and clinical examinations were conducted and patients completed Physical Health Questionnaire PHQ-15 questionnaires repeated at one and three months post-DTR therapy. Disclusion Times DT sEMG levels of masseter and temporalis muscles and symptom scores were recorded before and after the treatment. Data were analyzed using repeated measures ANOVA and Post hoc LSD tests.Results DTR treatment led to a reduction in the duration intensity and frequency of Menierersquos symptoms vertigo ear fullness and tinnitus evidenced by reduced group means P lt 0.00001. Improvements in disclu-sion times and electromyographic EMG values post-DTR therapy P lt0.0001 correlated with symptom relief at both one month and three months P lt0.0001 significantly.Conclusion Occlusal forces and timing were primary contributors to tinnitus and Menierersquos disease in these patients. Post-DTR therapy all subjects showed reductions in symptom intensity frequency and duration. Prolonged disclusion time may be an overlooked occlusal factor in Menierersquos disease suggesting that calibrated DTR therapy should be considered as a treatment option for MD.
Assessment of Parenting Stress and its Relationship with Oral Health Status of Children Aged 6-12 Years in Davangere City - A Cross-sectional Survey
Authors: Sulthana D S Gazala , B Sapna , M Bilal
Published: December 2024

Background and Objective Bounteous studies provide evidence of various parental factors influencing a childrsquos oral health. Only handful of studies have elucidated the relationship between parenting stress and oral health status of children in the Indian context. Hence the present study was planned to assess parenting stress and its relationship with the oral health status of children aged 6 to 12 years.Methods A survey was conducted among 420 parent-child dyads with children aged 6-12 years. A self-designed proforma was used for recording the sociodemographic details with a pre-validated Kannada version of Parenting stress scale PSS to assess the parenting stress followed by assessment of childrenrsquos oral health status. The Chi-square test Spearman correlation test and binary logistic regression analysis were applied by considering statistical significance at P lt0.05.Results Majority of parents reported experiencing moderate levels of parenting stress 91. When childrenrsquos oral health status was assessed more than half of children showed low caries experience 62.5 a milder form of gingivitis 96.2 and good oral hygiene status 57.4. No statistically significant association was found between parenting stress and the childrenrsquos oral health status.Conclusion In the present study the level of parenting stress did not have an impact on the childrenrsquos oral health status.
Effect of harvest time of day on the isoflavone synthesis pathway in immature
soybeans
Authors: Ismayawati A.D. , Yokoyama D. , Nishiguchi Y. , Saeki Y. , Sakakibara H.
Published: December 2024

Isoflavones, such as daidzein and genistein, are abundant in soybeans. As isoflavones
have many beneficial health effects, the development of methods to increase the amounts
of these compounds is important. In this study, the effect of harvest timing on expression
patterns of isoflavone synthase (IFS) and cinnamate 4-hydroxylase (C4H), two major
genes in the isoflavone synthesis pathway, in the pulp of immature soybeans from an open-air field were evaluated. The immature soybeans were collected at five different time
points over a 24-hour period, and the gene expressions and isoflavone amounts were
analyzed using reverse transcription-PCR and HPLC-diode array detector, respectively.
The results showed that C4H expression increased during the day and decreased at night,
although IFS expression tended to decrease during the middle of the night, but not
significantly. Whereas isoflavone content was decreased during the day. These results
suggested the possibility that the harvest of immature soybeans immediately after sunset is
desirable for increasing isoflavone amounts.
Exploration of Multi-Dimensional Collaborative Practice and Education Path for Electrical Engineering and Automation Major under the Background of “Dual Carbon”
Authors: Li Guangming , Zhang Qilong , Li Aijing , Zhang Yegui , Ji Chang , Zhu Kun , Feng Junjie
Published: December 2024

Driven by the strategic goal of “dual carbon,” the electric power industry is entering a critical period of transformation and upgrading, and there is a growing demand for composite and applied talents who are both proficient in professional technology and good at management. Taking the electrical engineering and automation major of Liupanshui Normal University as an example, this study addresses existing challenges in current talent cultivation practices. By emphasizing the deep integration of theory and practice and aligning closely with industry needs, the study aims to ensure that the talent cultivation system is both forward-looking and practical. Focusing on key aspects such as the practical teaching system, practice platforms, teaching content, instructional methods, assessment and evaluation strategies, and resource optimization, a series of targeted measures are proposed. These measures aim to construct a comprehensive, multi-dimensional practice education system that enhances students’ practical innovation abilities and overall competencies. This approach not only improves the quality of talent cultivation but also serves as a valuable reference for the development of electrical engineering education in similar local colleges and universities.
HOW PHASEOLUS VULGARIS L (CHEAKPEA) CAN REDUCE OF BLOOD SUGAR PRESURE IN TYPE 2 DIABETES MELLITUS
Authors: Marta Arnia Sactya , Hikmawati Isna , Isnaini Nur , Ramdani Meida Laely
Published: December 2024

Background: Diabetes over the past 10 decades has increased from 4.7% to 8.5% of the world population, Diabetes Mellitus Type 2 can be controlled by physical activity, diet, consumption of fruits and vegetables. The aim is to determine the effectiveness of chickpea juice on lowering blood sugar in patients with Type 2 Diabetes Mellitus. Methods: Research with quasy experiment design. This sample uses a categorical descriptive formula obtained 22 respondents who are categorized into 22 intervention groups and 22 control groups. Sampling using purposive sampling with inclusion criteria in diabetes millitus patients aged 53 - 77 years. The instrument used in this study used a questionnaire sheet, chickpea juice, and a blood sugar level checker using a blood sugar meter. Data analysis using wilcoxon test with α = 5%. Results: The study showed that most of the elderly were 54.55%, the most gender was female as much as 65.91%. In this study obtained results as many as 5 respondents (11.4%) with normal blood sugar and 17 respondents (38.6%) with hyperglycemia. There is a relationship between blood sugar levels in the intervention group given chickpea juice with a value (ρ value = 0.001, α = <0.005) and a decrease in SD of 94.5 mg/dL. Conclusion: There is a relationship between chickpea juice to reduce blood sugar levels in patients with Type 2 Diabetes Mellitus.
MEDIA FILM PENDEK BERHASIL MENINGKATKAN PENGETAHUAN REMAJA DALAM MENCEGAH PENGGUNAAN NAPZA
Authors: Aryandi Syahrul , Milkhatun Milkhatun , Widyastuti Dwi
Published: December 2024

Penyalahgunaan NAPZA sangat banyak terjadi pada kalangan remaja disebabkan berbagai faktor salah satunya karena kurangnya pengetahuan mengenai dampak negatif NAPZA mulai dari dampak terhadap fisik, sosial, ekonomi, psikologis bahkan dapat mengancam nyawa. Penelitian ini bertujuan untuk meningkatkan pemahaman remaja tentang NAPZA, melalui media edukasi kesehatan berupa film pendek Desain penelitian ini akan menggunakan kuantitatif dengan pendekatan pra experiment yaitu pre test dan post test pada kelompok intervensi yaitu kelompok intervensi edukasi kesehatan melalui media film pendek tentang NAPZA. Populasi pada penelitian adalah Siswa SMPN Samarinda kelas 8 sebanyak 227 dan sampel yang digunakan dengan menggunakan teori Borg & Gall sebanyak 15-30 tiap kelompok intervensi. Instrumen penelitian ini adalah kuesioner dan analisa data yang digunakan adalah uji Wilcoxon. Hasil uji wilcoxon didapatkan nilai p value 0,000 < α = 0,05. Kesimpulannya adalah terdapat pengaruh edukasi kesehatan dengan media film pendek terhadap pengetahuan dalam mencegah penggunaan NAPZA pada remaja SMP Negeri 9 Samarinda.
ANALISIS PROSEDUR PERAWATAN CYLINDER COMP DIES UNTUK MENURUNKAN DOWNTIME DIES FLASH DI PT XYZ
Authors: Kaswadi Agung , Wibowo Eko Ari , Triantoro Viko Wahyu
Published: December 2024

PT XYZ merupakan salah satu perusahaan manufaktur yang bergerak di bidang otomotif yang memproduksi sepeda motor dengan jumlah produksi terbesar di Indonesia. Secara garis besar, PT XYZ melakukan beberapa tahapan dalam proses pembuatan sepeda motor. Salah satu proses yang digunakan adalah High Pressure Die Casting untuk membuat komponen engine pada sepeda motor seperti Cylinder Comp, Left Crank Case dan Right Crank Case. High Pressure Die Casting Maintenance (HPDCM) merupakan salah satu bagian yang bertugas menyediakan dies siap produksi dengan kualitas yang baik. Pada area HPDCM, ditemukan masalah tingginya breakdown time pada Cylinder Comp A #4-0 akibat lamanya proses perbaikan masalah dies flash. Untuk itu, penelitian ini berfokus pada lamanya proses perbaikan dies flash pada Cylinder Comp A #4-0 dengan tujuan untuk menurunkan waktu perbaikan dies flash. Penelitian ini menggunakan metode eight steps dan seven tools sebagai alat bantu dalam penelitian. Setelah dilakukan analisis menggunakan fishbone diagram, penyebab lamanya perbaikan dies flash pada Cylinder Comp A adalah karena sering terjadi ulir slack pada saat proses perbaikan sehingga harus dilakukan perbaikan pada ulir yang memerlukan waktu yang lama. Perbaikan dilakukan dengan memodifikasi ulir menjadi insert pada dies Cylinder Comp A #4-0. Setelah silakukan perbaikan, rata-rata waktu perbaikan dies flash pada Cylinder Comp A #4-0 turun dari 60 menit/kasus menjadi 31 menit/kasus atau turun sebesar 48,3%.
David Barzanaya’nın Yalancı İsa Şiirinin İçerik Çözümü ve Mor Baselius’un Lawij’iyle Mukayesesi
Authors: Başçı Veysel
Published: December 2024

David Barzanaya 19. yy’da yaşamış bir Süryani/Keldani şairidir. Şiirleri arasında iki uzun Kürtçe şiir(i) de vardır. Bu şiirler Doğu Süryani hattıyla (Madnḥāyā) Kürtçenin Kurmancî diyalektiğinde yazılmış gerşunilerdir. Bunlardan Yalancı İsa-Deccal başlığını taşıyan ve toplam 26 dörtlükten oluşan şiiri, eskatoloji temelli bir şekvâiyye türüdür. Çünkü şair bu şiirinde, bireysel ve toplumsal diskurda karşılaştığı umutsuzluğu ve yaşadığı felaketleri Deccal, umudu ve kurtuluşu da İsa Mesih ile sembolize etmiş, şiirinde bu imgeleri, eskatolojik ve milenyumcu inanç çerçevesinde, düalistik bir mantıkla kullanmıştır. Şiirin duygu çağrışımında ise gelecek zaman ile hâl birlikte işlenmiş, devrin sosyal ve siyasal eleştirilerine de sahip olduğundan, bizzat şairi tarafından “efkâr-ı umumîyenin dikkatine” sunulmuştur. Bu çalışmada, kavramsal çerçeve ve semantik yönleriyle birlikte incelenen şekvâiyye’nin, 18. yy’da yaşamış Turabdin-Gozarto (Midyat-Cizre) Baş Metropolti Mor Baselius Şem’un’un Kürtçe Lawij’iyle içerik açısından benzerlikler taşıdığı, her iki eserinde eskatolojiye dayalı bir şekvâiyye türü olduğu dolaysıyla mezkûr Lawij’in Kürtçe konuşan Süryani/Keldani edipleri arasında, “edebî bir üslup ve gelenek” olarak kullanıldığı da saptanmıştır.
NİETZSCHE BAĞLAMINDA FOUCAULT’DA HAKİKATİN KÖKENİNE DAİR SOYBİLİMSEL BİR ANALİZ
Authors: Şengül Yüksel
Published: December 2024

Batı felsefesinde, etkisi Platon’a kadar uzanan kökene dayalı bir hakikat anlayışı, sorgulanmaya değer önemli bir konudur. Ancak kökene dayandırılarak bir hakikatin inşası, temel evrensel değerlerin ve sorgulanamayan kutsal bir alanın oluşturulmak istenmesi açısından oldukça dikkat çekicidir. Peki, genellikle yadsınamayan ve pek tartışılmayan bir gerçeklik olarak kabul edilen hakikat, bir kökene sahip midir ya da hakikatin bir tarihinden söz edilebilir mi? Bu sorular, siyasi ve çağdaş felsefi tartışmalarda hala merkezi bir yer tutmaktadır. Bu soruya genellikle olumlu cevap verenler olsa da olumsuz cevap verenler de olmuştur. Olumsuz cevap verenler arasında birçok kişi sayılabilir ve onlardan ikisi de Nietzsche ve Foucault’dur. Her iki düşünür, hakikatin göreceliğinin başlıca savunucularından biri olarak görülür. Foucault, Nietzsche’nin de etkisinde kalarak, hakikatin yayılma tarzı ve bağlantıları hakkında spesifik bazı tarihsel, kültürel ve yönetimsel etkiler olduğunu öne sürmektedir. Ne Nietzsche’nin ne de Foucault’nun çalışmalarında hakikatin reddi söz konusu değildir. Ancak Foucault, hakikati tarihsel bir kategoride görerek hakikatin tarihini yapma denemesine girişir. O, bu hakikat tarihini, kökenin insan için anlamını ve tarihsel süreç içerisindeki etkilerini ve hakikate dönüşme şeklini Nietzsche’den devşirdiği soybilim ile tarihsel bir değerlendirmeye tabi tutarak analiz eder. Foucault’ya göre tarihsel her bir dönemin hakikati de o dönemin koşullarınca ve bilhassa o dönemin epistemesinden hareketle belirlenir. Hem Nietzsche hem de Foucault’da hakikat, nesnellikten ve evrensellikten yoksunken Foucault, hakikatin iktidar etkileriyle şekillenen bir tarihsellik içerdiğini düşünmektedir.
SAHÂBENİN ADALETİ BAĞLAMINDA İBN HAZM’IN EBÜ’T-TUFEYL’E YAKLAŞIMI
Authors: Kaya Hüsamettin
Published: December 2024

Hadislerin sıhhatini tespit etmede isnat kontrol mekanizmasi olarak geliştirilen cerh ve ta’dil ilmi, ravileri adalet ve zabt yönüyle değerlendirmeye tabi tutmaktadır. İsnadın ilk halkası olan sahâbe nesli, ehl-i sünnet âlimleri tarafından adil kabul edilmelerinden dolayı erken dönemde her ne kadar adalet yönüyle cerhe konu olmadığı söylenilse de vakıa böyle olmamıştır. Nitekim icmâ olmasa da sahâbî olduğu hussusunda cumhur ittifakı bulunan Ebü’t-Tufeyl (ö. 100/718-19), Muhtâr es-Sekâfî’nin (ö. 67/687) görüşleri savunmakla tenkit edilmiştir. Bu cerh, sahâbenin adaleti bağlamında düşünüldüğünde Ebü’t-Tufeyl’in naklettiği rivayetlerin sıhhatine halel getirmemesi gerekmektedir. Ricâl âlimlerinin cumhuru da bu görüşte olacak ki Ebü’t-Tufeyl’i cerhte bulunurken rivayetlerinde sika olduğunun altını çizmişlerdir. Onların bu yaklaşımı hadis mecmualarına da yansıdığının kanaatindeyiz. Zira başta kütüb-i sitte olmak üzere birçok hadis eserinde Ebü’t-Tufeyl’in rivayetlerini görmek mümkündür. Ancak bu durum İbn Hazm için geçerli olmamıştır. Zira Ebü’t-Tufeyl’in birden fazla rivayetini konu edinen ve onlarla görüşlerini destekleyen İbn Hazm, yeri geldğinde söz konusu kişinin rivayetini cerhinden bağımsız değerlendirirken yeri geldiğinde aynı cerh nedeniyle rivayetlerini reddettiği görülmektedir.
STABILITAS WARNA DAN PERUBAHAN pH WEDANG UWUH SIAP MINUM SELAMA PENYIMPANAN
Authors: Septiyani Retnosyari , Rahayu Wahidah Mahanani , Permadi Adi
Published: December 2024

Wedang uwuh is a traditional drink from Yogyakarta with various product forms. Ready-to-drink wedang uwuh is a more practical and economical alternative for consumption, but with limited color stability around 1 day. This research aims to examine the color stability of ready-to-drink wedang uwuh at varying temperatures and brewing times, at room and cool temperature, and with sugar or Na-benzoate addition. The experiment was carried out in a Completely Randomized Design with a variety of brewing conditions of temperature (75°C, 85°C, and 95°C) and time (10, 15, and 20 minutes) at material and water ratio of 1:1 (wv), followed by filtration and storage. The filtrate was then observed for changes in color for 7 days. Brewing condition with best color stability at 85oC for 20 minutes were then treated with the addition of sugar or sodium benzoate and then tested for pH and color for 9 days storage in cool and room temperature. The research results showed that all samples (original, sugar added, and Na-benzoate added) had pH color change during storage, but original and Na-benzoate added had the best stability. Ready-to-drink wedang uwuh stored in cold temperature had better red color stability than room storage.
PENILAIAN INDEKS KERENTANAN BENCANA BANJIR BANDANG BERBASIS SIG DI SUB DAS AIR BETUNG KOTA PAGAR ALAM
Authors: Azizah Barrorotul
Published: December 2024

Kota Pagar Alam merupakan salah satu daerah di Indonesia yang termasuk ke dalam daerah yang rawan terjadi bencana. Kota Pagar Alam sangat rentan terhadap bencana banjir bandang, berdasarkan DIBI (Data Informasi Bencana Indonesia) dalam kurun waktu 10 tahun terakhir telah terjadi bencana banjir bandang sebanyak 7 kali dengan korban jiwa sebanyak 2 orang, kerusakan rumah 3 unit, dan 15 Ha sawah yang terendam.Berdasarkan hal tersebut maka diperlukan suatu kajian mitigasi terhadap bencana banjir bandang di Kota Pagar alam. Aspek terpenting dalam mitigasi bencana adalah penilaian terhadap kerentanan wilayah berpotensi rawan bencana. Dan metode yang dapat digunakan dalam pengkajiannya adalah kombinasi dari metode Pengindraan Jauh dan Sistem Informasi Geografis (SIG). Acuan yang digunakan dalam penilaian dan pembobotannya adalah Peraturan Kepala Badan Nasional Penanggulangan Bencana Nomor 2 Tahun 2012 Tentang Pedoman Umum Pengkajian Risiko. Terdapat empat parameter penilaian yaitu, parameter kerentanan sosial, kerentanan ekonomi, kerentanan fisik dan kerentanan lingkungan. Hasil penelitian menunjukkan bahwa kota Pagar Alam memiliki indeks kerentanan banjir bandang dengan kategori “kerentanan sedang”, dengan rata-rata nilai indeks kerentanan (0,59). Peta Indeks Kerentanan memberikan informasi berupa tingkat kerentanan masing-masing kecamatan yang tersebar di Daerah Aliran Sungai Air Betung Kota Pagar Alam parameter kerentanan sosial, kerentanan ekonomi, kerentanan fisik dan kerentanan lingkungan.
Global perspective on bovine abortion - current prevalences, normal rates, diagnoses and aetiologies: a mini-review
Authors: Mee John F.
Published: December 2024

The case definition of bovine abortion varies with the purpose of use from legislative and research to field definitions; it generally encompasses days 42–260 of gestation. This variation can affect comparisons between prevalence rates. Animal-level prevalence estimates vary between 5 and 20% (mean ~10%) while herd-levels vary between 0 and 30% in published studies. Intervention thresholds (‘normal herd-level abortion rate’) also vary widely from 1 to 10% depending on the case definition and the underlying region-specific abortion rate. The infectious abortion diagnosis rate globally is ~45% with Neospora caninum being the most commonly detected abortifacient. Thus, the majority of abortions, in particular, sporadic (not outbreak) cases, have no diagnosed cause. However, current advances in the routine application of molecular diagnostics both for pathogens and for lethal alleles is steadily reducing this diagnosis-not-reached rate.
Evaluation of β-hydroxybutyrate, calcium, and non-esterified fatty acids at day one postpartum in predicting the risk of diseases in dairy cows
Authors: Safak Tarik , Durukan Efe , Yilmaz-Koc Oznur , Risvanli Ali , Soyturk Berrak Isik , Bayraktar Metin
Published: December 2024

In this study, the usability of calving type, non-esterified fatty acids (NEFA), β-hydroxybutyrate (BHB), and calcium (Ca) concentrations in predicting postpartum diseases was examined. For this purpose, 120 Holstein cows were used in the study. These cows were divided into two subgroups according to the calving type: unassisted parturition (eutocic, n = 58) and assisted parturition (dystocia, n = 62). Cows were followed for 15 days postpartum. Diseases of retained foetal membranes (RFM), metritis, and clinical mastitis that developed in the postpartum period were recorded. Then, NEFA, BHB, and Ca concentrations were measured in blood samples collected at parturition from cows with RFM (n = 19), metritis (n = 34), clinical mastitis (n = 20) and cows that did not develop the disease (n = 47). Our results show the decreased Ca concentration to be positively associated with the risk of mastitis (P < 0.001, odds ratio [OR] 4.599), metritis (P = 0.008, OR 4.286), and RFM (P < 0.001, OR 5.016); and increased BHB concentration to be positively associated with the risk of metritis (P = 0.002, OR 4.069) and RFM (P < 0.001, OR 9.498). The results of the study indicated that low Ca and high BHB concentration at parturition could negatively affect the productive efficiency of dairy cows.
THE AUSTIN HEALTHCARE PROJECT: A PROJECT MANAGER’S ETHICAL DILEMMA
Authors: D Berthot Bryan
Published: December 2024

Long-term organizational success, particularly in business service industries such as information technology (IT) and software development, has been shown to be linked to ethical behavior by company employees. A project manager (PM) is the “face of the project” for internal and external customers and ideally is an organizational leader in ethical decision-making. This case illustrates what happens when a project manager is faced with multiple ethical quandaries and explains what options the PM has in responding to such situations.
Scott Fink: Steering Business and Philanthropy in Tampa Bay
Authors: Crabtree Dalton , Giuliani Erica , Shiflet Donald
Published: December 2024

This study presents an in-depth analysis of the entrepreneurial journey of an individual, Scott Fink, within the auto sales industry, through a series of interviews. With data collected and analyzed through the grounded-theory approach to industry interviews, explores the multifaceted nature of entrepreneurship, emphasizing the critical roles of relationships, financial freedom, opportunism, persistence, survival, and leadership in achieving business success. Drawing upon Stevenson's Opportunity-Based Theory of Entrepreneurship, the research underscores the significance of pursuing opportunities irrespective of current resources and the importance of value creation through customer relationships and community engagement. The findings highlight the complex interplay between personal experiences, industry dynamics, and entrepreneurial success, offering a nuanced understanding of the pathways to achieving financial independence and making a societal impact. This study contributes to the entrepreneurship literature by providing empirical insights into the application of theoretical frameworks in a real-world context and suggesting directions for future research on the evolving landscape of entrepreneurial opportunities.
Doing business and economic growth in Latin America, 2010-2020
Authors: Naranjo Navas Bryan Josué , Naranjo Navas Christian Paúl
Published: December 2024

The article analyzes the ease of opening businesses in Latin America, and its relationship with economic growth during the decade 2010-2020. The objective of the study was the evaluation of the correlation between these two variables. It started with the idea that the ease and policies that benefit business opening are highly correlated with economic growth. The results show that our hypothesis is true, namely: as the ease of opening new businesses increases, while bureaucratic obstacles are reduced, economic growth increases, which contributes to a decrease in unemployment.
Análisis del clima de negocios en Ecuador desde la perspectiva de los inversores nacionales y extranjeros
Authors: Guerrero Patricia , Proaño Bladimir , Sancho David
Published: December 2024

Tanto los inversores nacionales como extranjeros aportan capital, tecnología y abren oportunidades de inversión en los mercados internacionales. Sin embargo, su comportamiento es sensible a la incertidumbre, los cambios políticos, las fluctuaciones económicas y otros eventos imprevistos, lo que hace necesario un análisis detallado para su correcta dirección y control. Se llevó a cabo un estudio cuantitativo utilizando cuestionarios (basados en un barómetro del clima de negocios) que fueron dirigidos a los altos directivos de las empresas. El objetivo fue recopilar su opinión sobre la valoración e importancia que otorgan a diversos aspectos de sus empresas. Se definieron cinco categorías y 21 ítems con una escala de Likert, los cuales fueron probados en 50 empresarios. A partir del análisis factorial, el número de categorías se incrementó a siete. Los resultados revelaron que la baja estabilidad macroeconómica, la corrupción y otros factores políticos fueron identificados como problemáticos, subrayando la complejidad del entorno empresarial. En cambio, los factores tecnológicos fueron evaluados como los menos problemáticos. Así, este análisis permitió obtener una comprensión más detallada de los factores que conforman el clima de negocios en Ecuador. Esto es fundamental para proponer estrategias y políticas efectivas, además de proporcionar una visión clara que facilite la implementación de mejoras y fomente la resiliencia empresarial en el contexto actual del país.
50 ÉVES A DEBRECENI UROLÓGIAI KLINIKA
Authors: Tóth Csaba
Published: December 2024

A significant milestone in the history of the Urology Clinic in Debrecen was celebrated with a jubilee lecture series held on May 10, 2024. Urological patients were initially treated from 1921 at the Faculty of Medicine of the István Tisza University of Debrecen, within the Surgical Clinic led by Tivadar Hüttl. In 1958, an independent urology department and outpatient clinic began operations within the Surgical Clinic, and in 1972, the urology care system was relocated to the II. Surgical Clinic at its current location. The independent Urology Clinic was officially established on July 1, 1974, under the leadership of Márton Kelenhegyi. In 1979, József Pintér became the clinic’s director, followed by Csaba Tóth in 1995. Professor Tóth introduced numerous open and endoscopic urological surgical procedures, was a founding figure in the field, mentored many renowned urologists both nationally and internationally, and placed strong emphasis on scientific rigor. Since 2006, the clinic has been led by Associate Professor Tibor Flaskó, who has further developed laparoscopic procedures. In 2022, the former Urology Department of Kenézy Gyula Hospital was integrated into the structure of the Urology Clinic
REFLEXIÓK A MELBOURN-I EGYETEM JOGI KARÁNAK MEGALAKULÁSÁRÓL
Authors: Haitas Daniel
Published: December 2024

This study attempts to survey certain aspects of the founding of the University of Melbourne and its law school in the British Crown Colony of Victoria (the present-day Australian State of Victoria). This includes looking at the historical background and impetus behind the establishment of these institutions. Furthermore, the paper has a certain migration studies aspect, specifically discussing the important role of certain Irish Protestants in the early history of Victoria’s legal profession, the University of Melbourne and its law school.
MUCHALINDA: THE SERPENT KING IN BUDDHIST MYTHOLOGY
Authors: Bhoi Kamala Kant , Bhoi Chandrika , Barik Alfa Anupama Priyadarshini , Barik Shreekant
Published: December 2024

Muchalinda, the serpent king, is a significant figure in Buddhist mythology, known for protecting Gautama Buddha from the evils after his enlightenment. This article explores the development of Muchalinda's character, his artistic representations, and the archaeological significance of the Muchalinda image discovered in Ganiapali, Odisha. The article highlights the importance of Muchalinda in Buddhist art and culture, and sheds light on the history and cultural heritage of Odisha.