bluuebunny/crossref_metadata_2025 huggingface dataset:
Mathematical Modeling and Nonlinear Optimization in Determining the Minimum Risk of Legalization of Income from Criminal Activities in the Context of EU Member Countries
Authors: Vagaská Alena , Gombár Miroslav , Korauš Antonín
Published: December 2022

Legalization of the proceeds of crime represents a worldwide problem with serious economic and social consequences. Information technologies in conjunction with advanced computer techniques are important tools in the fight against money laundering (ML), financial crime (FC) and terrorism financing (TF). Nowadays, the applied literature on ML/FC/TF uses much more mathematical modelling as a solving strategy to estimate illicit money flows. However, we perceive that there is preference of linear models of economical dependences and sometimes lack of acceptance of nonlinearity of such investigated economic systems. To characterize the risk of legalization of crime proceeds in a certain country, the scientific researchers use the Basel anti-money laundering (AML) index. To better understand how the global indicators (WCI, CPI, EFI, GII, SEDA, DBI, GSCI, HDI, VATGAP, GDP per capita) affect the level of risk of ML/TF in the countries of EU, the authors use a unique data set of 24 destination countries of EU over the period 2012–2019. The article deals with two main research goals: to develop a nonlinear model and optimize the ML/TF risk by implementation of nonlinear optimization methods. The authors contribute: (i) providing the cross-country statistical analysis; (ii) creating the new nonlinear mathematical-statistical computational model (MSCM); and (iii) describing the observed dependent variable (Basel AML index). This study deepens previous knowledge in this research field and, in addition to the panel regression analysis, also applies nonlinear regression analysis to model the behavior of the investigated system (with nonlinearity). Our results point out the differences between the estimates of the investigated system behavior when using panel and nonlinear regression analysis. Based on the developed MSC model, the optimization procedure is conducted by applying an interior point method and MATLAB toolboxes and the second goal is achieved: the statement that such values of input variables at which the risk of legalization of income from criminal activity will be minimal.
Solution of Integral Equations Using Some Multiple Fixed Point Results in Special Kinds of Distance Spaces
Authors: Rashid Maliha , Saleem Naeem , Bibi Rabia , George Reny
Published: December 2022

In this paper, we explore some extensions of multiple fixed point results for various distance spaces such as s-distance space, s,q-distance space, and balanced distance space. Some examples are also discussed for the elaboration of these generalized structures. An application of our result that demonstrates the existence of a unique solution of a system of integral equations is also provided.
Analog Circuits
Authors: Fortuna Luigi , Buscarino Arturo
Published: December 2022

Analog circuits are essential in everyday life and in electrical engineering [...]
Antimicrobial Activity and Immunomodulatory Properties of Acidocin A, the Pediocin-like Bacteriocin with the Non-Canonical Structure
Authors: Antoshina Daria V. , Balandin Sergey V. , Bogdanov Ivan V. , Vershinina Maria A. , Sheremeteva Elvira V. , Toropygin Ilia Yu. , Finkina Ekaterina I. , Ovchinnikova Tatiana V.
Published: December 2022

Pediocin-like bacteriocins are among the natural antimicrobial agents attracting attention as scaffolds for the development of a new generation of antibiotics. Acidocin A has significant structural differences from most other members of this subclass. We studied its antibacterial and cytotoxic activity, as well as effects on the permeability of E. coli membranes in comparison with avicin A, the typical pediocin-like bacteriocin. Acidocin A had a more marked tendency to form an alpha-helical structure upon contact with detergent micelles, as was shown by CD spectroscopy, and demonstrated considerably less specific mode of action: it inhibited growth of Gram-positive and Gram-negative strains, which were unsusceptible to avicin A, and disrupted the integrity of outer and inner membranes of E. coli. However, the peptide retained a low toxicity towards normal and tumor human cells. The effect of mutations in the pediocin box of acidocin A (on average, a 2–4-fold decrease in activity) was less pronounced than is usually observed for such peptides. Using multiplex analysis, we showed that acidocin A and avicin A modulated the expression level of a number of cytokines and growth factors in primary human monocytes. Acidocin A induced the production of a number of inflammatory mediators (IL-6, TNFα, MIG/CXCL9, MCP-1/CCL2, MCP-3/CCL7, and MIP-1β) and inhibited the production of some anti-inflammatory factors (IL-1RA, MDC/CCL22). We assumed that the activity of acidocin A and similar peptides produced by lactic acid bacteria might affect the functional state of the human intestinal tract, not only through direct inhibition of various groups of symbiotic and pathogenic bacteria, but also via immunomodulatory effects.
Technology for Complex Processing of Electric Smelting Dusts of Ilmenite Concentrates to Produce Titanium Dioxide and Amorphous Silica
Authors: Karshyga Zaure , Ultarakova Almagul , Lokhova Nina , Yessengaziyev Azamat , Kassymzhanov Kaisar , Myrzakulov Maxat
Published: December 2022

This paper presents the results of research on the development of a technology intended to process electric smelting dusts of ilmenite concentrate with the extraction of silicon and titanium and the production of products in the form of their dioxides. Dusts were processed for silicon separation using the ammonium fluoride method. The optimum conditions for the fluorination and sublimation process of silicon compounds from the electric smelting dust of the ilmenite concentrate were determined: a temperature of 260 °С, a 6 h duration, and mass ratio of dust to ammonium bifluoride of 1:0.5 ÷ 0.9. The sublimation degree of silicon compounds was ~84–91%. The sublimation of titanium fluorides from the remaining sinter was carried out at a temperature of 600 ± 10 °C for 2 h, the mass ratio titanium-containing residue: ammonium bifluoride of 1:0.5, and the degree of sublimation of titanium fluorides was 99%. Iron, manganese, and chromium impurities in the sublimation of titanium fluorides sublimate to a rather low degree. Pyrohydrolysis of titanium fluoride sublimes at 600 °C and allows for the conversion of fluorides into titanium dioxide by 99.5% in 4–5 h. Titanium dioxide of rutile modification with 99.8% TiO2 was obtained after hydrochloric acid purification and calcination. A technological scheme for the complex processing of dust from the electric smelting of ilmenite concentrates with the production of silica and titanium dioxide is proposed.
Properties of Unburned Brick Produced by Entirely Waste-Stream Binder Activated by Desulfurization Gypsum
Authors: Zhang Lei , Guo Lijie , Zhao Yue , Li Mengyuan
Published: December 2022

The massive accumulation of industrial solid wastes such as circulating fluidized bed fly ash (CFA), silicon-calcium slag (SCS), and desulfurization gypsum (FGD) occupy land resources and bring varying degrees of pollution to soil, water, and atmosphere. Unburned brick is a new construction material prepared from industrial waste residues such as fly ash and tailings without high-temperature calcination. It has excellent potential in consuming large quantities of industrial solid waste. In this paper, 70% of CFA and 30% of SCS are used as the primary raw materials, and the FGD is used as the activator to prepare unburned bricks by static pressure forming. The mechanical properties of the specimens at different curing ages were tested by compressive strength test. The hydration mechanism and microstructure of unburned brick were investigated by X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive spectrometer (EDS), thermogravimetric (TG), Fourier transform infrared spectroscopy (FTIR), and inductively coupled plasma-optical emission spectrometry (ICP-OES). The results show that the compressive strength of the specimen increases first and then decreases with the increase of FGD content, and the compressive strength reaches the maximum when the FGD content is 5%. The microscopic test results show that the presence of FGD promoted a higher degree of CFA and SCS dissolution, increasing ettringite formation, which is responsible for strength increase, but extreme doses of FGD resulted in strength degradation. Meanwhile, the higher SiO2/Al2O3 ratio confirms the simultaneous formation of hydrated calcium silicate (C-S-H) gel and hydrated calcium aluminosilicate (C-A-S-H) gel within the hydrated product, while a low SiO2/Al2O3 ratio confirms the simultaneous formation of ettringite.
Identification of D-Limonene Metabolites by LC-HRMS: An Exploratory Metabolic Switching Approach in a Mouse Model of Diet-Induced Obesity
Authors: Rinaldi de Alvarenga José Fernando , Lei Preti Caroline , Santos Martins Lara , Noronha Hernandez Guilherme , Genaro Brunna , Lamesa Costa Bruna , Gieseler Dias Caroline , Purgatto Eduardo , Fiamoncini Jarlei
Published: December 2022

Metabolic switching has been raised as an important phenomenon to be studied in relation to xenobiotic metabolites, since the dose of the exposure determines the formation of metabolites and their bioactivity. Limonene is a monoterpene mostly found in citrus fruits with health activity, and its phase II metabolites and activity are still not clear. The aim of this work was to evaluate the effects of D-limonene in the development of diet-induced obesity in mice and to investigate metabolites that could be generated in a study assessing different doses of supplementation. Animals were induced to obesity and supplemented with 0.1% or 0.8% D-limonene added to the feed. Limonene phase I and II metabolites were identified in liver and urine by LC-ESI-qToF-MS/MS. To the best of our knowledge, in this study three new phase I metabolites and ten different phase II metabolites were first attributed to D-limonene. Supplementation with 0.1% D-limonene was associated with lower weight gain and a trend to lower accumulation of adipose tissue deposits. The metabolites limonene-8,9-diol, perillic acid and perillic acid-8,9-diol should be explored in future research as anti-obesogenic agents as they were the metabolites most abundant in the urine of mice that received 0.1% D-limonene in their feed.
Supplementation of Methyl-Donor Nutrients to a High-Fat, High-Sucrose Diet during Pregnancy and Lactation Normalizes Circulating 25-Dihydroxycholecalciferol Levels and Alleviates Inflammation in Offspring
Authors: Teoh Chin May , Cooper Analynn , Renteria Karisa M. , Lane Michelle , Zhu Jie , Koh Gar Yee
Published: December 2022

A Western-style diet that is high in fat and sucrose has been shown to alter DNA methylation and epigenetically modify genes related to health risk in offspring. Here, we investigated the effect of a methyl-donor nutrient (MS) supplemented to a high-fat, high-sucrose (HFS) diet during pregnancy and lactation on vitamin D (VD) status and inflammatory response in offspring. After mating, 10-week-old female Sprague-Dawley (SD) rats (n = 10/group) were randomly assigned to one of the four dietary groups during pregnancy and lactation: (1) control diet (CON), (2) CON with MS (CON-MS), (3) HFS, and (4) HFS with MS (HFS-MS). Weanling offspring (three weeks old) were euthanized and sacrificed (n = 8–10/sex/group). The remaining offspring (n = 10/sex/group) were randomly assigned to either a CON or an HFS diet for 12 weeks and sacrificed at 15 weeks of age. Our results indicated that prenatal MS supplementation, but not postnatal diet, restored low vitamin D status and suppressed elevation of proinflammatory cytokine induced by maternal HFS in the offspring. Furthermore, both prenatal and postnatal diets modulated the abundance of Lactobacillus spp. and Bacteroides spp. in the offspring, a shift that was independent of vitamin D status. Collectively, our data support a role for MS in restoring the perturbation of VD status and normalizing maternal HFS-induced inflammation in the offspring. Further investigation is warranted to elucidate the methylation status of VD metabolism-related pathways in the offspring, as well as the immunomodulatory role of vitamin D during the progression of obesity.
Film Thickness and Glycerol Concentration Mapping of Falling Films Based on Fluorescence and Near-Infrared Technique
Authors: Medina Isabel , Scholl Stephan , Rädle Matthias
Published: December 2022

Falling film evaporation processes involve high fluid velocities with continuous variations in local film thickness, fluid composition, and viscosity. This contribution presents a parallel and complementary film thickness and concentration mapping distribution in falling films using a non-invasive fluorescence and near-infrared imaging technique. The experiments were performed with a mixture of glycerol/water with a mass fraction from 0 to 0.65 gglycgtotal−1 and operating ranges similar to evaporation processes. The measurement system was designed by integrating two optical measurement methods for experimental image analysis. The film thickness was evaluated using a VIS camera and high-power LEDs at 470 nm. The local glycerol concentration gglycgtotal−1 was determined using a NIR camera and high-power LEDs at 1050, 1300, 1450 and 1550 nm. A multiwavelength analysis with all NIR wavelengths was implemented with a better correlation for falling films at low flow velocity. The results show an improvement in the analysis of falling films with high flow velocities up to almost 500 mm/s by using only the 1450 nm wavelength and the fluorescence measurement. Simultaneous imaging analysis of film thickness and concentration in falling films provides further insight into understanding mass and heat transport and thus supports the optimization of falling film evaporators.
Investigation of Material Removal Distributions and Surface Morphology Evolution in Non-Contact Ultrasonic Abrasive Machining (NUAM) of BK7 Optical Glasses
Authors: Guo Zongfu , Luo Xichun , Hu Xiaoping , Jin Tan
Published: December 2022

A non-contact ultrasonic abrasive machining approach provides a potential solution to overcome the challenges of machining efficiency in the high-precision polishing of optical components. Accurately modeling the material removal distribution (removal function (RF)) and surface morphology is very important in establishing this new computer-controlled deterministic polishing technique. However, it is a challenging task due to the absence of an in-depth understanding of the evolution mechanism of the material removal distribution and the knowledge of the evolution law of the microscopic surface morphology under the complex action of ultrasonic polishing while submerged in liquid. In this study, the formation of the RF and the surface morphology were modeled by investigating the cavitation density distribution and conducting experiments. The research results showed that the material removal caused by cavitation bubble explosions was uniformly distributed across the entire working surface and had a 0.25 mm edge influence range. The flow scour removal was mainly concentrated in the high-velocity flow zone around the machining area. The roughness of the machined surface increased linearly with an increase in the amplitude and gap. Increasing the particle concentration significantly improved the material removal rate, and the generated surface exhibited better removal uniformity and lower surface roughness.
Real-Time Detection of Drones Using Channel and Layer Pruning, Based on the YOLOv3-SPP3 Deep Learning Algorithm
Authors: Zhang Xuetao , Fan Kuangang , Hou Haonan , Liu Chuankai
Published: December 2022

Achieving a real-time and accurate detection of drones in natural environments is essential for the interception of drones intruding into high-security areas. However, a rapid and accurate detection of drones is difficult because of their small size and fast speed. In this paper a drone detection method as proposed by pruning the convolutional channel and residual structures of YOLOv3-SPP3. First, the k-means algorithm was used to cluster label the boxes. Second, the channel and shortcut layer pruning algorithm was used to prune the model. Third, the model was fine tuned to achieve a real-time detection of drones. The experimental results obtained by using the Ubuntu server under the Python 3.6 environment show that the YOLOv3-SPP3 algorithm is better than YOLOV3, Tiny-YOLOv3, CenterNet, SSD300, and faster R-CNN. There is significant compression in the size, the maximum compression factor is 20.1 times, the maximum detection speed is increased by 10.2 times, the maximum map value is increased by 15.2%, and the maximum precision is increased by 16.54%. The proposed algorithm achieves the mAP score of 95.15% and the detection speed of 112 f/s, which can meet the requirements of the real-time detection of UAVs.
Low Salt Influences Archaellum-Based Motility, Glycerol Metabolism, and Gas Vesicles Biogenesis in Halobacterium salinarum
Authors: Onga Evelyn Ayumi , Vêncio Ricardo Z. N. , Koide Tie
Published: December 2022

Halobacterium salinarum NRC-1 is an extremophile that grows optimally at 4.3 M NaCl concentration. In spite of being an established model microorganism for the archaea domain, direct comparisons between its proteome and transcriptome during osmotic stress are still not available. Through RNA-seq-based transcriptomics, we compared a low salt (2.6 M NaCl) stress condition with 4.3 M of NaCl and found 283 differentially expressed loci. The more commonly found classes of genes were: ABC-type transporters and transcription factors. Similarities, and most importantly, differences between our findings and previously published datasets in similar experimental conditions are discussed. We validated three important biological processes differentially expressed: gas vesicles production (due to down-regulation of gvpA1b, gvpC1b, gvpN1b, and gvpO1b); archaellum formation (due to down-regulation of arlI, arlB1, arlB2, and arlB3); and glycerol metabolism (due to up-regulation of glpA1, glpB, and glpC). Direct comparison between transcriptomics and proteomics showed 58% agreement between mRNA and protein level changes, pointing to post-transcriptional regulation candidates. From those genes, we highlight rpl15e, encoding for the 50S ribosomal protein L15e, for which we hypothesize an ionic strength-dependent conformational change that guides post-transcriptional processing of its mRNA and, thus, possible salt-dependent regulation of the translation machinery.
Towards Green Strategies of Food Security: Antibacterial Synergy of Essential Oils from Thymus vulgaris and Syzygium aromaticum to Inhibit Escherichia coli and Staphylococcus aureus Pathogenic Food Isolates
Authors: Sateriale Daniela , Forgione Giuseppina , De Cristofaro Giuseppa Anna , Facchiano Serena , Boscaino Floriana , Pagliuca Chiara , Colicchio Roberta , Salvatore Paola , Paolucci Marina , Pagliarulo Caterina
Published: December 2022

Foodborne diseases continue to represent an important public health issue. The control of food spoilage and pathogenic microorganisms is achieved mainly by synthetic chemicals, unfortunately associated to several undesirable aspects. The growing requirement for new and safe alternative strategies has resulted in the research of agents from natural sources with antimicrobial properties, such as essential oils (EOs). This study’s purpose was to define the antibacterial profile of thyme (Thymus vulgaris) and cloves (Syzygium aromaticum) essential oils against both Gram-positive and Gram-negative important foodborne pathogenic bacteria. Gas chromatography mass spectrometry analysis was performed for EOs’ chemical composition. Qualitative in vitro antimicrobial assays (i.e., agar well diffusion method and disk-volatilization method) allowed for verification of the efficacy of EOs, used individually and in binary combination and both in liquid and vapor phase, against Staphylococcus aureus and Escherichia coli food isolates. Minimal inhibitory concentrations and minimal bactericidal concentration values have been used to quantitatively measure the antibacterial activity of EOs, while the fractional inhibitory concentration index has been considered as a predictor of in vitro antibacterial synergistic effects. The microbiological tests suggest that thyme and cloves EOs, rich in bioactive compounds, are able to inhibit the growth of tested foodborne bacteria, especially in vapor phase, also with synergistic effects. Results provide evidence to consider the tested essential oils as promising sources for development of new, broad-spectrum, green food preservatives.
Serological and Molecular Survey of Leishmania infantum in a Population of Iberian Lynxes (Lynx pardinus)
Authors: Lima Clara M. , Santarém Nuno , Neves Nuno Costa , Sarmento Pedro , Carrapato Carlos , de Sousa Rita , Cardoso Luís , Cordeiro-da-Silva Anabela
Published: December 2022

Leishmania infantum, the sand fly-transmitted protozoan parasite responsible for leishmaniasis in humans, dogs, and cats, is endemic in the Iberian Peninsula. However, the impact of L. infantum infection on the conservation of the endangered Iberian lynx (Lynx pardinus) is unknown. Herein, we describe for the first time the occurrence of L. infantum infection among a population of reintroduced and wild-born L. pardinus living in the Portuguese Guadiana Valley Park. The presence of infection was addressed by molecular detection of Leishmania kinetoplast DNA (kDNA) in 35 lynxes, with further confirmation of L. infantum species performed by an internally transcribed spacer (ITS)-1 sequencing. Eight blood samples were positive for kDNA, and ITS-1 sequencing confirmed the presence of L. infantum in two of those samples. Exposure to Leishmania was screened in a group of 36 lynxes using an immunofluorescence antibody test (IFAT) and a multi-antigen enzyme-linked immunosorbent assay (ELISA), using SPLA, rK39, and CPX as Leishmania-specific antigens. Four animals presented a positive IFAT at a dilution of 1:40. Eight samples were considered seropositive to all ELISA Leishmania-specific antigens. Agreement between PCR, IFAT, and all ELISA antigens was found for 1 in 27 samples. These results highlight the susceptibility of autochthonous L. pardinus to L. infantum infection. Further investigation is required to assess the impact of L. infantum infection on this wild species conservation.
Hydrothermal Alteration Zones’ Magnetic Susceptibility Footprints and 3D Model of Iron Oxide-Copper-Gold (IOCG) Mineralization, Carajás Mineral Province, Brazil
Authors: Leão-Santos Marcelo , Moraes Roberto , Li Yaoguo , Raposo Maria Irene , Zuo Boxin
Published: December 2022

Brownfield areas are important targets of exploration; however, the extensive drilling present in these areas has not fully exploited their prospective potential. The appropriate use of drill hole cores in these areas can play an important role in deep exploration. We present a case study of iron oxide-copper-gold (IOCG) Furnas Southeast deposit, located in the Carajás Mineral Province, Brazil. This deposit has disseminated chalcopyrite, bornite and gold mineralization associated with a silicic (Si), potassic (K), calcic (Na), sodic-calcic (Na-Ca) hydrothermal alteration, and intense iron metasomatism with massive magnetite (Fe) alteration. Petrophysical hand-held equipment measurements were carried out on drill core samples with the purpose of studying the potential roles that magnetic susceptibility properties can play in high-grade mineralization. The results indicate that the geological complexity of the IOCG deposit is readily reflected in the extensive variation of the measurements. The statistical analysis shows how the detailed characterization of this physical property carried out for this mineral association could effectively define and describe ore, and the magnetic susceptibility footprints of hydrothermal alteration zones. Furthermore, we were able to perform a magnetic susceptibility 3D modeling of diamagnetic, paramagnetic, and ferrimagnetic responses strictly correlated with known orebody. Thus, petrophysical analyses can form a quantitative geological criterion for ore delineation.
Automatic Cutting Speed Control System of Boom-Type Roadheader Based on Geological Strength Index
Authors: Dong Zheng , Zhang Xuhui , Yang Wenjuan , Lei Mengyu , Zhang Chao , Wan Jicheng , Han Lei
Published: December 2022

The boom-type roadheader is the foremost mining equipment in coal mines. At present, the automatic cutting technology is still immature for adjusting cutting speed automatically in accordance with rock strength, resulting in energy dissipation. In this study, we put forward a method with respect to detecting the geological strength index of coal seam profile through visual inspection, as well as characterize the geological strength index and control the cutting head for adjusting speed automatically based on inspecting fracture features on coal rock’s surface, aiming at achieving energy conservation control of boom-type roadheader. The image processing algorithm is adopted for detecting joint characteristics of palisades fracture, and a quantitative model of the geological strength index is established. The fractal dimension is used to obtain the distribution of geological strength indicators of a coal seam, and the heading machine’s cutting head is controlled for adjusting speed automatically. A vision control platform of boom-type roadheader is built in the laboratory to perform ground simulation experiments. According to experimental results, the difference between the geological strength index of the coal seam detected through visual inspection and the set value in the geological strength index chart is up to 3.5%, and the results are basically consistent, so the quantification of geological strength index can be performed rapidly and effectively. The average energy consumption of boom-type roadheader decreases by 5.4% after adopting self-adaptation control, realizing energy conservation and consumption reduction as well as intelligent control of coal mine machinery.
Distributed Polarizability Model for Covalently Bonded Fullerene Nanoaggregates: Origins of Polarizability Exaltation
Authors: Sabirov Denis Sh. , Tukhbatullina Alina A.
Published: December 2022

Polarizability exaltation is typical for (C60)n nanostructures. It relates to the ratio between the mean polarizabilities of (C60)n and C60: the first one is higher than the n-fold mean polarizability of the original fullerene. This phenomenon is used in the design of novel fullerene compounds and the understanding of its properties but still has no chemical rationalization. In the present work, we studied the distributed polarizability of (C60)2 and isomeric (C60)3 nanoaggregates with the density functional theory method. We found that polarizability exaltation increases with the size of the nanostructure and originates from the response of the sp2-hybridized carbon atoms to the external electric field. The highest contributions to the dipole polarizability of (C60)2 and (C60)3 come from the most remote atoms of the marginal fullerene cores. The sp3-hybridized carbon atoms of cyclobutane bridges negligibly contribute to the molecular property. A similar major contribution to the molecular polarizability from the marginal atoms is observed for related carbon nanostructures isomeric to (C60)2 (tubular fullerene and nanopeanut). Additionally, we discuss the analogy between the polarizability exaltation of covalently bonded (C60)n and the increase in the polarizability found in experiments on fullerene nanoclusters/films as compared with the isolated molecules.
Machine Learning-Based Characterization of the Nanostructure in a Combinatorial Co-Cr-Fe-Ni Compositionally Complex Alloy Film
Authors: Nagy Péter , Kaszás Bálint , Csabai István , Hegedűs Zoltán , Michler Johann , Pethö László , Gubicza Jenő
Published: December 2022

A novel artificial intelligence-assisted evaluation of the X-ray diffraction (XRD) peak profiles was elaborated for the characterization of the nanocrystallite microstructure in a combinatorial Co-Cr-Fe-Ni compositionally complex alloy (CCA) film. The layer was produced by a multiple beam sputtering physical vapor deposition (PVD) technique on a Si single crystal substrate with the diameter of about 10 cm. This new processing technique is able to produce combinatorial CCA films where the elemental concentrations vary in a wide range on the disk surface. The most important benefit of the combinatorial sample is that it can be used for the study of the correlation between the chemical composition and the microstructure on a single specimen. The microstructure can be characterized quickly in many points on the disk surface using synchrotron XRD. However, the evaluation of the diffraction patterns for the crystallite size and the density of lattice defects (e.g., dislocations and twin faults) using X-ray line profile analysis (XLPA) is not possible in a reasonable amount of time due to the large number (hundreds) of XRD patterns. In the present study, a machine learning-based X-ray line profile analysis (ML-XLPA) was developed and tested on the combinatorial Co-Cr-Fe-Ni film. The new method is able to produce maps of the characteristic parameters of the nanostructure (crystallite size, defect densities) on the disk surface very quickly. Since the novel technique was developed and tested only for face-centered cubic (FCC) structures, additional work is required for the extension of its applicability to other materials. Nevertheless, to the knowledge of the authors, this is the first ML-XLPA evaluation method in the literature, which can pave the way for further development of this methodology.
Low Solar Absorptance, High Emittance Performance Thermochromic VO2-Based Smart Radiator Device
Authors: Hendaoui Ali
Published: December 2022

Thermochromic vanadium dioxide (VO2)-based smart radiator devices (SRDs) display emittance variation with changes in temperature, making them very promising for energy-efficient thermal control of spacecrafts in general, and nanosatellites in particular. However, the high solar absorptance of the VO2-based SRDs remains too high for their intended application. Based on an approach combining optical simulation and experimental work, I demonstrate that an additional top stack layer alternating between high and low refractive indices made of a-Si(25 nm)/SiO2(67 nm) reduces the solar absorptance of a VO2-based SRD by 35% (from 0.43 to 0.28) while keeping the emittance performance of the SRD within the requirements for the intended application (low-temperature emittance εL = 0.35, high-temperature emittance εH = 0.81 and emittance tuneability with temperature Δε = 0.46). I also discuss factors to consider while designing additional top stack layers alternating between high and low refractive indices to further decrease the SRD’s solar absorptance without affecting its emittance performance.
Safety of Deep Repetitive Transcranial Magnetic Stimulation (drTMS) against Medical Refractory Symptoms in Parkinson Syndromes: First German Real-World Data with a Specific H5 Coil
Authors: Cont Celine , Lehto Annaliis , Stute Nathalie , Galli Anastasia , Schulte Christina , Deer Veronika , Wessler Michaela , Wojtecki Lars
Published: December 2022

So far, deep repetitive transcranial magnetic stimulation (drTMS) has shown promising results as an add-on treatment for Parkinson’s disease (PD) but not for non-idiopathic Parkinson Syndromes (PS). We aimed to investigate the safety and feasibility of drTMS application in patients with different Parkinson Syndromes and medical refractory symptoms. Multifaceted real-world data (n = 21) were retrospectively analyzed regarding adverse effects as well as short-term effects of the drTMS treatment on patients’ self-rated symptom severity and motor, cognitive, and emotional functions. The drTMS treatment with H5 coil included a sequential 1 Hz primary motor cortex stimulation contralateral to the more-affected body side and a bilateral 10 Hz stimulation of the prefrontal cortex. Overall, drTMS could be safely administered to patients with different PSs and medical refractory symptoms, but large variation was apparent in the rate and severity ratings of the reported adverse event/adverse device effect. The treatment significantly decreased the subjective main symptom severity. This effect was more pronounced in older patients with PD. Furthermore, analysis showed an improvement in depression, but no effect could be established in terms of cognitive performance. drTMS can be safely administered to patients with PS and medical refractory symptoms and can decrease the subjective motor symptom severity and depression.
Hypomagnesemia and the Metabolic Syndrome among Apparently Healthy Kuwaiti Adults: A Cross-Sectional Study
Authors: Alkazemi Dalal , Alsouri Noora , Zafar Tasleem , Kubow Stan
Published: December 2022

Magnesium plays a key role in metabolic disorder development, and hypomagnesemia may be implicated in the pathogenesis of metabolic syndrome (MetS) and its components. In this cross-sectional study, we investigated the associations between hypomagnesemia, MetS, and MetS components among 231 adults (193 women and 38 men) living in Kuwait who were apparently healthy without chronic diseases. We used the International Diabetes Federation (IDF) and the United States National Cholesterol Education Program Adult Treatment Panel III (ATP III) criteria to define participants with MetS. The Ministry of Health cutoff for hypomagnesemia (<0.74 mmol/L) was employed. IDF- and ATP III-defined MetS prevalence was 22.1% and 15.2%, respectively. Hypomagnesemia occurred in 33.3% of all participants and 53.2% of participants with MetS (p < 0.001). Magnesemia correlated negatively with body mass index, waist circumference, systolic blood pressure [SBP], diastolic blood pressure (DBP), fasting blood glucose (FBG), low-density lipoprotein cholesterol level, and triglyceride level; magnesemia correlated positively with high-density lipoprotein cholesterol (HDL-C) levels (p < 0.001). Multivariate logistic regression, adjusting for BMI, age, and sex, showed that hypomagnesemia was associated with a 12- and 5-fold greater odds of getting IDF-defined (adjusted odds ratio [aOR] 11.70; 95% confidence interval [CI] 4.87–28.14) and ATP-defined (aOR 5.44; 95% CI 2.10–14.10) MetS, respectively, in the study population. Hypomagnesemia was significantly associated with a 3.62, 9.29, 7.01, 2.88, 3.64, and 3.27 higher odds of an increased waist circumference (95% CI 1.48–8.85), elevated serum triglyceride level (95% CI 3.97–21.73), elevated FBG (95% CI 3.25–15.11), elevated SBP (95% CI 1.16–7.11), elevated DBP (95% CI: 1.22–10.89), and lowered HDL-C level (95% CI 1.69–6.32), respectively. Hypomagnesemia could be a consequence of the pathophysiology of MetS and its individual components among adults in Kuwait.
Association between Metabolic Phenotypes of Body Fatness and Incident Stroke: A Prospective Cohort Study of Chinese Community Residents
Authors: Tang Minhua , Zhao Qi , Yi Kangqi , Wu Yiling , Xiang Yu , Zaid Maryam , Cui Shuheng , Su Xuyan , Yu Yuting , Zhao Genming , Jiang Yonggen
Published: December 2022

This study aimed to assess the association of body mass index (BMI)-based and waist circumference (WC)-based metabolic phenotypes with the risk of stroke among Chinese community residents. A total of 34,294 participants (mean ± standard deviation age: 56.05 ± 11.26 years) with no previous stroke diagnosis history were included in this cohort study. BMI-based metabolic phenotypes were classified into eight groups: metabolically healthy and normal weight (MHNW), metabolically healthy and underweight (MHUW), metabolically healthy and overweight (MHOW), metabolically healthy and obese (MHO), metabolically unhealthy and normal weight (MUNW), metabolically unhealthy and underweight (MUUW), metabolically unhealthy and overweight (MUOW), and metabolically unhealthy and obese (MUO). WC-based metabolic phenotypes were classified into four groups: metabolically healthy and normal WC (MHNWC), metabolically healthy and oversized WC (MHOWC), metabolically unhealthy and normal WC (MUNWC), and metabolically unhealthy and oversized WC (MUOWC). The association of these phenotypes with developing stroke events was examined using proportional hazards models. A total of 546 cases of first-stroke onset were recorded over a median follow-up time of 4.97 years. Compared with the reference group, the obesity phenotypes showed higher risks for stroke. The adjusted HRs (95% CIs) of MHUW, MHOW, MHO, MUNW, MUUW, MUOW, and MUO phenotypes were 1.01 (0.41, 2.49), 1.47 (1.09, 2.00), 1.33 (0.80, 2.22), 2.49 (1.87, 3.30), 3.92 (1.44, 10.72), 2.14 (1.64, 2.79), and 2.60 (1.91, 3.55), respectively. The adjusted HRs (95% CIs) of MHOWC, MUNWC, and MUOWC were 1.41 (1.02, 1.94), 2.25 (1.76, 2.87), and 2.16 (1.63, 2.87), respectively. The metabolic phenotypes defined by an alternative definition all showed significant positive associations (except for MHUW), with the adjusted HR ranging from 1.51 to 3.08 based on BMI and from 1.68 to 2.24 based on WC. The risk of stroke increased with the increase in metabolic abnormality numbers in different BMI and WC groups (all p trend < 0.001). The present study suggests that maintaining normal body weight or WC and improving metabolic health are of great significance in preventing cerebrovascular diseases.
Waist Circumference Trajectories in Relation to Blood Pressure and the Risk of Hypertension in Chinese Adults
Authors: Wang Qi , Song Xiaoyun , Du Shufa , Du Wenwen , Su Chang , Zhang Jiguo , Zhang Xiaofan , Zhang Bing , Wang Huijun
Published: December 2022

Central obesity is associated with a higher risk of hypertension. This study aimed to analyze waist circumference (WC) trajectories and discover their association with blood pressure and the risk of hypertension. The data were obtained from the China Health and Nutrition Survey (CHNS), with a sample of 11,885 adults aged 18 or older. Trajectory groups of WC were identified by group-based trajectory modeling. Three trajectory groups were identified in males: “normal-stable group” (group 1), “normal-increase to central obesity group” (group 2), and “central obesity-slight decrease group” (group 3). There were also three identified in females: “normal-increase to central obesity group” (group 1), “normal-stable group” (group 2), and “central obesity-increase group” (group 3). For males, compared with group 1, systolic blood pressure (SBP) and diastolic blood pressure (DBP) increased by 2.47 mmHg and 2.13 mmHg, respectively, in group 2, and by 3.07 mmHg and 2.54 mmHg, respectively, in group 3. The adjusted hazard ratios (HR) and 95% confidence interval (95% CI) of hypertension in groups 2 and 3 were 1.16 (1.06–1.28) and 1.29 (1.10–1.50), respectively. For females, compared with group 2, SBP and DBP increased by 1.69 mmHg and 1.68 mmHg, respectively, in group 1, and by 4.96 mmHg and 2.77 mmHg, respectively, in group 3. The HR and 95% CI of hypertension in groups 2 and 3 were 1.21 (1.07–1.36) and 1.52(1.17–1.99), respectively. We found that the WC trajectory was a risk factor for hypertension and elevated blood pressure independent of basal WC. Increased risk of hypertension was nonlinearly associated with annual WC increase.
Review of the Role of Ferroptosis in Testicular Function
Authors: Yang Xu , Chen Yunhe , Song Wenxi , Huang Tingyu , Wang Youshuang , Chen Zhong , Chen Fengjuan , Liu Yu , Wang Xuebing , Jiang Yibao , Zhang Cong
Published: December 2022

Iron is an important metal element involved in the regulation of male reproductive functions and has dual effects on testicular tissue. A moderate iron content is necessary to maintain testosterone synthesis and spermatogenesis. Iron overload can lead to male reproductive dysfunction by triggering testicular oxidative stress, lipid peroxidation, and even testicular ferroptosis. Ferroptosis is an iron-dependent form of cell death that is characterized by iron overload, lipid peroxidation, mitochondrial damage, and glutathione peroxidase depletion. This review summarizes the regulatory mechanism of ferroptosis and the research progress on testicular ferroptosis caused by endogenous and exogenous toxicants. The purpose of the present review is to provide a theoretical basis for the relationship between ferroptosis and male reproductive function. Some toxic substances or danger signals can cause male reproductive dysfunction by inducing testicular ferroptosis. It is crucial to deeply explore the testicular ferroptosis mechanism, which will help further elucidate the molecular mechanism of male reproductive dysfunction. It is worth noting that ferroptosis does not exist alone but rather coexists with other forms of cell death (such as apoptosis, necrosis, and autophagic death). Alleviating ferroptosis alone may not completely reverse male reproductive dysfunction caused by various risk factors.
Can Lactoferrin, a Natural Mammalian Milk Protein, Assist in the Battle against COVID-19?
Authors: Einerhand Alexandra Wilhelmina Carla , van Loo-Bouwman Carolien Annika , Weiss Gisela Adrienne , Wang Caiyun , Ba Genna , Fan Qicheng , He Baoping , Smit Gerrit
Published: December 2022

Notwithstanding mass vaccination against specific SARS-CoV-2 variants, there is still a demand for complementary nutritional intervention strategies to fight COVID-19. The bovine milk protein lactoferrin (LF) has attracted interest of nutraceutical, food and dairy industries for its numerous properties—ranging from anti-viral and anti-microbial to immunological—making it a potential functional ingredient in a wide variety of food applications to maintain health. Importantly, bovine LF was found to exert anti-viral activities against several types of viruses, including certain SARS-CoV-2 variants. LF’s potential effect on COVID-19 patients has seen a rapid increase of in vitro and in vivo studies published, resulting in a model on how LF might play a role during different phases of SARS-CoV-2 infection. Aim of this narrative review is two-fold: (1) to highlight the most relevant findings concerning LF’s anti-viral, anti-microbial, iron-binding, immunomodulatory, microbiota-modulatory and intestinal barrier properties that support health of the two most affected organs in COVID-19 patients (lungs and gut), and (2) to explore the possible underlying mechanisms governing its mode of action. Thanks to its potential effects on health, bovine LF can be considered a good candidate for nutritional interventions counteracting SARS-CoV-2 infection and related COVID-19 pathogenesis.
Association between the Preoperative C-Reactive Protein-to-Albumin Ratio and the Risk for Postoperative Pancreatic Fistula following Distal Pancreatectomy for Pancreatic Cancer
Authors: Funamizu Naotake , Sogabe Kyosei , Shine Mikiya , Honjo Masahiko , Sakamoto Akimasa , Nishi Yusuke , Matsui Takashi , Uraoka Mio , Nagaoka Tomoyuki , Iwata Miku , Ito Chihiro , Tamura Kei , Sakamoto Katsunori , Ogawa Kohei , Takada Yasutsugu
Published: December 2022

Postoperative pancreatic fistula (POPF) are major postoperative complications (POCs) following distal pancreatectomy (DP). Notably, POPF may worsen the prognosis of patients with pancreatic cancer. Previously reported risks for POCs include body mass index, pancreatic texture, and albumin levels. Moreover, the C-reactive protein-to-albumin ratio (CAR) is a valuable parameter for prognostication. On the other hand, POCs sometimes lead to a worse prognosis in several cancer types. Thus, we assumed that CAR could be a risk factor for POPFs. This study investigated whether CAR can predict POPF risk in patients with pancreatic cancer following DP. This retrospective study included 72 patients who underwent DP for pancreatic cancer at Ehime University between January 2009 and August 2022. All patients underwent preoperative CAR screening. Risk factors for POPF were analyzed. POPF were observed in 17 of 72 (23.6%) patients. POPF were significantly associated with a higher CAR (p = 0.001). The receiver operating characteristic curve analysis determined the cutoff value for CAR to be 0.05 (sensitivity: 76.5%, specificity: 88.9%, likelihood ratio: 6.88), indicating an increased POPF risk. Univariate and multivariate analysis revealed that CAR ≥ 0.05 was a statistically independent factor for POPF (p < 0.001, p = 0.013). Therefore, CAR has the potential to predict POPF following DP.
Association between Adherence to the Healthy Food Pyramid and Breast Milk Fatty Acids in the First Month of Lactation
Authors: Ramiro-Cortijo David , Herranz Carrillo Gloria , Gila-Diaz Andrea , Ruvira Santiago , Singh Pratibha , Braojos Cheyenne , Martin Camilia R. , Arribas Silvia M.
Published: December 2022

In lactating women, breast milk (BM) fatty acids may come from the diet or stored adipose tissue. Our objective was to evaluate the influence of the adherence to the healthy food pyramid (HFP), the dietary pattern in the Mediterranean region, and the maternal body composition on the BM fatty acids pattern. Fifty breastfeeding women answered a socioeconomic survey and the adherence to the HFP questionnaire (AP-Q). In addition, they provided a BM sample at 7 ± 1, 14 ± 1, and 28 ± 1 days postpartum. The body’s composition was analyzed at days 7 and 28 by bioimpedance. The BM fatty acids were analyzed by gas chromatography–mass spectroscopy. We found a negative association between the consumption of olive oil and the BM palmitic acid levels (β = −3.19 ± 1.40; p = 0.030), and the intake of cereals and legumes was positively associated with the BM saturated fatty acids (β = 11.48 ± 3.87; p = 0.005). The intake of proteins and vegetables was positively associated with the omega-3 fatty acids and negatively with the omega-6:omega-3 ratio in BM. A negative association between the maternal age (β = −0.43 ± 0.11; p = 0.001) and the α-linolenic acid (ALA) levels was observed, being overall AP-Q positively associated with the ALA levels (β = 0.39 ± 0.15; p = 0.016). Physical activity reduced both the omega-3 and omega-6 fatty acids in BM. Diet had a larger influence than the maternal body’s composition on BM fatty acids during the first month of lactation, demonstrating a better adherence to the HFP and positively impacting on the omega-3 content in BM, a fact that is modulated by one’s maternal age.
Hesperidin Reversed Long-Term N-methyl-N-nitro-N-Nitroguanidine Exposure Induced EMT and Cell Proliferation by Activating Autophagy in Gastric Tissues of Rats
Authors: Liang Zhaofeng , Song Jiajia , Xu Yumeng , Zhang Xinyi , Zhang Yue , Qian Hui
Published: December 2022

Gastric cancer is a common malignant tumor worldwide. N-methyl-N-nitro-N-nitroguanidine (MNNG) is one of the most important inducing factors of gastric cancer. Autophagy can affect the occurrence and development of gastric cancer, but the mechanism is not clear. Chemoprevention has been shown to be a rational and very promising approach to the prevention of gastric cancer. Hesperidin is a citrus flavone, an abundant polyphenol in citrus fruits and traditional Chinese medicine. It has an excellent phytochemistry that plays an intervention role in gastric cancer. However, it is unclear whether long-term exposure to MNNG will affect the occurrence of gastric cancer by regulating autophagy and whether hesperidin can play an intervention role in this process. In the present study, we demonstrated that long-term MNNG exposure inhibits autophagy in stomach tissues of rats, promotes the epithelial–mesenchymal transition (EMT) process and cell proliferation and suppresses the activity of the PI3K/AKT pathway. We further found that after rapamycin-activated autophagy, long-term MNNG exposure promoted cell proliferation and EMT were inhibited. In addition, hesperidin promotes autophagy and the activity of the PI3K/AKT pathway, as well as the suppression of proliferation and EMT in the stomach tissues of rats. Our findings indicate that hesperidin reverses MNNG-induced gastric cancer by activating autophagy and the PI3K/AKT pathway, which may provide a new basis for the early prevention and treatment of MNNG-induced gastric cancer.