bluuebunny/crossref_metadata_2025 huggingface dataset:
KIỂM TRA VÀ GIÁM SÁT MỘT SỐ VI SINH VẬT GÂY BỆNH TRÊN ĐỘNG VẬT THÍ NGHIỆM BẰNG PHƯƠNG PHÁP NUÔI CẤY
Authors: Hưng Hoàng Trung , Hiếu Nguyễn Chí , Hồng Trần Thị , Thảo Quách Thu , Thơm Trần Thị Hương , Thành Mẫn Thị
Published: May 2022

Việc kiểm tra và giám sát một số vi khuẩn gây bệnh trên chuột lang và chuột nhắt thí nghiệm tại Viện Kiểm định Quốc gia Vắc xin và Sinh phẩm y tế (NICVB) rất quan trọng trong việc đánh giá sức khỏe động vật, từ đó ảnh hưởng tới tính chính xác khi dùng động vật thí nghiệm trong các thử nghiệm kiểm định chất lượng vắc xin và sinh phẩm y tế. Nhằm mục đích xây dựng quy trình thường quy và giám sát chất lượng động vật thí nghiệm tại NICVB, việc kiểm tra và giám sát một số tác nhân vi khuẩn theo khuyến cáo của đoàn đánh giá thuộc Tổ chức Y tế Thế giới (WHO) sử dụng tài liệu hướng dẫn của Liên đoàn các hiệp hội động vật thí nghiệm châu Âu (FELASA), được thực hiện bằng phương pháp nuôi cấy và định danh bằng máy định danh vi sinh vật BD Phoenix M50. Kết quả kiểm tra và giám sát một số tác nhân vi khuẩn gây bệnh trên 100 chuột lang trước thử nghiệm và 100 chuột nhắt trước thử nghiệm từ tháng 3/2021 đến tháng 12/2021 cho thấy, chỉ phát hiện vi khuẩn Staphylococcus aureus với tỷ lệ nhiễm 26% đối với chuột nhắt ICR và 24% đối với chuột lang. Như vậy, chất lượng động vật thí nghiệm nuôi tại NICVB đảm bảo tiêu chuẩn để cung cấp cho các thử nghiệm kiểm định vắc xin và sinh phẩm y tế.
ĐÁNH GIÁ TÍNH ỔN ĐỊNH NHIỆT VẮC XIN MẪU CHUẨN QUỐC GIA HEAMOPHILUS INFLUENZAE TUÝP B LẦN THỨ NHẤT
Authors: Kiều Nguyễn Thị , Thiển Đoàn Hữu , Lệ Đường Thị Cẩm , Trang Cảnh Huyền , Liễu Đàm Thị
Published: May 2022

Viện Kiểm định Quốc gia Vắc xin và Sinh phẩm Y tế đã thiết lập loạt vắc xin mẫu chuẩn quốc gia Heamophilus influenzae type b với mã số MCQG.Hib.01 nhưng chưa đưa ra hạn sử dụng cho loạt mẫu chuẩn. Với mục tiêu đưa ra được hạn sử dụng dự kiến, chúng tôi đã thực hiện nghiên cứu “đánh giá tính ổn định nhiệt vắc xin mẫu chuẩn quốc gia heamophilus influenzae type b lần thứ nhất” bằng phương pháp thúc đẩy nhiệt. Kết quả, sau 40 năm, loạt mẫu chuẩn MCQG.Hib.01 vẫn đạt yêu cầu với hàm lượng 5,181063 mg/lọ mg Polyribosyl Ribitol Phosphat trong 1 lọ.
KIỂM TRA CÔNG HIỆU IN VITRO VẮC XIN VIÊM NÃO NHẬT BẢN BẤT HOẠT BẰNG PHƯƠNG PHÁP ELISA
Authors: Lý Nguyễn Thị , Bách Nguyễn Kim , Anh Nguyễn Việt , Yến Lê Thị Hải , Thủy Đào Thị , Ánh Đỗ Thị Hồng
Published: May 2022

ELISA là một trong những phương pháp định lượng kháng nguyên có nhiều ưu điểm: nhanh chóng, đơn giản, chính xác, phù hợp với các mẫu có hàm lượng protein và độ tinh khiết cao. Nhằm đánh giá sự phù hợp của phương pháp ELISA trong kiểm tra công hiệu in vitro vắc xin Viêm não Nhật Bản bất hoạt, từ tháng 2 đến tháng 8 năm 2020, tại Khoa kiểm định vắc xin vi rút – Viện Kiểm định Quốc gia Vắc xin và Sinh phẩm y tế, chúng tôi đã tiến hành nghiên cứu thực nghiệm trong phòng thí nghiệm để đánh giá độ đúng, độ chính xác, độ mạnh, độ đặc hiệu, tính tuyến tính của quy trình này. Quy trình làm theo bộ kit ELISA thương phẩm của Hàn Quốc. Kết quả các tiêu chí đều đạt yêu cầu của ISO/IEC 17025:2017 và WHO/VSQ/97.02 về độ đúng, độ chính xác, độ mạnh, độ đặc hiệu, tính tuyến tính của quy trình với khoảng tuyến tính (phát hiện) từ 42-663 ng/ml.
Research on Product Elements’ Safety-Critical Degree
Authors: Qiong Wu , Mingrui Lyu
Published: May 2022

According to system safety practice, the safety of a system is a designed characteristic. Therefore, the role of safety in the lifecycle of the system is important to consider during the design phase. There are many factors affecting product safety, and each of them plays a part in determining a product’s overall safety. It’s important to locate isolate key elements that influence a product’s overall safety, and design with those factors in mind, as well as the time, cost and effectiveness of their influence on the design phase.

The concept of “safety-critical” has long been a part of the system safety field, and scholars from different countries have studied safety-critical items in a system; unfortunately, the concept can be somewhat subjective and, often, disagreement occurs. These judgments can be affected by many factors and can cause inaccurate assumptions about which parts are critical, as well as encourages deviation in product development and maintenance that can cause serious consequences to product safety.
From the Editor's Desk
Authors: Ericson Clif
Published: May 2022

Is social media changing the way we interact and learn in our profession? Back in the day, when I was a new engineer in the system safety profession, it was difficult to find experts in the field to help explain basic concepts and processes. Typically, we had to join an engineering society, such as the International System Safety Society, and attend a technical conference to interact with knowledgeable and experienced individuals in the system safety discipline. Today, it seems we are trending toward obtaining information from social media groups, such as LinkedIn. It’s obviously cheaper than joining a professional society or going to a conference. But there are also some downsides. For example, many times I have witnessed answers given to questions, and the answers were misleading and/or totally wrong. The old adage that “you get what you pay for” really is applicable to the Internet.

In Memoriam: Rene Fitzpatrick and Don Ammerman
Unintended Consequences
Authors: Hardy Terry
Published: May 2022

On October 21, 2008, Reactor Unit 2 at the Diablo Canyon Power Plant in San Luis Obispo County, California was manually scrammed when operators detected inadequate flow of cooling water to the circulating water system. The power plant obtained cooling water from the Pacific Ocean. The water entered an intake structure by passing through bar racks, and then flowed through traveling screen assemblies. The bar racks and screens prevented debris and sea life from entering the circulating water pumps.
An Innovative Method to Hypothesis Testing for System Safety Assessment
Authors: Thomas Robert , Eichelberger Marilyn , Lee Missey , Haan Joel
Published: May 2022

The way forward in system safety engineering will be quantitative, and this paper proposes an innovative method for generating a uniform way to understand the composite of testing and experience. In recent years, new approaches to exact hypothesis testing have been developed without a Gaussian probability distribution for success or failure rates. These techniques eliminate errors introduced by the Gaussian assumption, which is important for the small failure rates that are common in modern systems development, and offer considerable promise as a basis for the new direction.

This paper presents a theory for exact hypothesis testing and combines two 18th-century theorems to derive an equation for the probability distribution of failure rate employing only the number of tests and the observed count of failures. The concept is expanded to demonstrate the combination of operational experience and expert opinion to update test results. The objective in this work is to derive the general likelihood distribution of failure rate given any set of test results, and then to examine the implications regarding testing requirements, design and interpretation. The particular application considered here is safety assessment for a military weapons system. While the theory developed is for deriving the exact failure rate distribution for system safety applications, it is equally valid for investigating success rates and/or for interpreting performance evaluation tests.
Management of Risks and Benefits for Medical Devices
Authors: Elahi Bijan
Published: May 2022

Medical device safety is of paramount importance. Application of the international standard ISO 14971 is mandatory for obtaining approval for commercialization of medical devices. One of the requirements of ISO 14971 is demonstration that the residual risk of the medical device is outweighed by the benefits that it offers to the patients. This poses a difficult challenge for the medical device manufacturers, as risk and benefit are not easily comparable. This comparison must be done on each hazard and also on the overall system. Some of the challenges that device manufacturers face are: How do you determine the overall residual risk of the system? And, if you do determine the overall residual risk, how do you know if it is acceptable? How do you compare the residual risk against the benefit of the device? For example, if the benefit is improved quality of life, but at a 0.1 percent increased risk of death, which is greater — the benefit or the risk? This paper offers techniques and methodologies to provide objective evidence that the device design has met the risk benefit requirements of ISO 14971.
TBD
Authors: Hoes Charles
Published: May 2022

The discussion concerning possible future directions for the ISSS have continued since the 2015 Conference in San Diego, California. This discussion centers around the question of whether, in this time of dwindling membership and financial resources, the ISSS should continue to operate as it has during the past three or four decades, or try something new and bold for the future.

It is my opinion that now is a great time to strive for something new and bold. Since I joined the Society in the 1980s, it has always been my contention that this organization promotes the most important approach to ensuring the safety of systems and products, large and small. The founders and members of the Society have crafted a spectacularly successful approach for the identification and mitigation of potential hazards and risks early during the design and development process where appropriate and cost-effective solutions can be integrated into the overall design under consideration. As I have mentioned on numerous occasions, it is my observation that there is a tendency for industries and organizations to begin to implement system safety principles in standards, requirements and processes — only to eventually change direction back toward their old ways of depending upon compliance to detailed design-based standards. This is done, rather than trusting the analysis-based approach that we have proven effective on literally trillions of dollars of programs spanning from small and relatively simple systems, to the most complex and innovative projects in the world.
Sex Offspring Ratio and Radiofrequency Radiation Exposure
Authors: Boulais Denis
Published: May 2022

Radiofrequency (RF) radiation is a silent and invisible hazard for both high-access window cleaners and telecommunications riggers that can heat body tissue, resulting in injury. In this study, a total of 68 high-access window cleaners were interviewed to establish their sex offspring ratio. Results indicated that there was no significant variance to that of the general Australian population.

The high-access window cleaning industry has a lower awareness of this hazard than the telecommunications industry. This study compares and contrasts its outcomes against a similar study within the telecommunications industry (n = 68), which also identified no significant variance.

As mobile telecommunication networks expand, the risk for high-access window cleaners will increase. Therefore, the study recommended that high-access window cleaning companies should revise their safety systems to ensure this hazard is addressed. A further recommendation was that this study should be repeated in the future to determine if expanding telecommunications networks and increased potential exposure has affected sex offspring ratios.
Some Legal Considerations of System Safety
Authors: Muniak Charles
Published: May 2022

Our work in system safety requires some knowledge of the legal system and liability concepts. The first two technical papers in this issue of Journal of System Safety address some emerging aspects of this topic. Of course, we should always confer with our corporate legal authorities for any specific legal issues with our work.
From the Editor's Desk
Authors: Muniak Charles
Published: May 2022

System safety professionals must not only keep an eye on the here and now — determining where hazards exist and ways to eliminate or avoid them — but also must be aware of the future. New technologies may help lead to safer outcomes, but in many cases, these breakthroughs bring with them their own issues. The field of system safety must keep up and adapt to the ever-evolving world.
Role of Regulators in Safeguarding the Interface Between Autonomous Systems and the General Public
Authors: Johnson Chris
Published: May 2022

Regulators play a critical role in the commercial exploitation of new technologies. They protect the public when market competition might persuade companies to take undue risks. At the same time, it is essential that regulatory authorities do not kill innovation by imposing inappropriate rules or by retaining previous requirements that make little sense in the light of technical innovations. These tensions are apparent in the introduction of autonomous and semi-autonomous systems, across a range of industries. “Regulatory lag” has starved companies of the strategic guidance that is necessary to make informed decisions about acceptable levels of safety and security for the integration of these technologies. This paper argues that existing product-based, process-based and performance-based approaches to regulation threaten the safe and secure exploitation of new markets. In contrast, we advocate a competent, anticipatory, self-reflective approach, which places performance requirements on the regulator rather than on the markets they protect.
Klausurtraining Besonderes Verwaltungsrecht
Authors: Winkler Markus
Published: May 2022

Das Besondere Verwaltungsrecht versammelt zunächst eine Vielzahl von unterschiedlichen Teilbereichen des öffentlichen Rechts. Neben der „Verklammerung“ durch das allgemeine Verwaltungsrecht gibt es aber auch in den Teilbereichen des besonderen Verwaltungsrechts gemeinsame Grundstrukturen und typische Problemkonstellationen, die immer wieder kehren, und deren Einübung und Beherrschung bei der Lösung verwaltungsrechtlicher Klausuren essentiell sind. Das Klausurtraining hilft dabei, den berühmten „roten Faden“ in der Fallbearbeitung verwaltungsrechtlicher Klausuren zu erkennen. Mit ihm erlernen Sie das notwendige Rüstzeug, um auch Fälle aus vermeintlich exotischen Teilbereichen des besonderen Verwaltungsrechts sicher und mit einer gut vertretbaren Argumentation bearbeiten zu können.
Sex differences in the cognitive performance in adults: role of impaired sleep
Authors: Medeiros Luciane de Souza , Santos Flavia H. , Almeida Alana Peixoto , Alves Davyd M.O. , Rocca Renan Remaeh , Tufik Sergio , Ximenes-da-Silva Adriana
Published: May 2022

Objectives: Poor sleep quality negatively affects cognitive performance. However, there are limited data on sex differences in functional outcomes of impaired sleep on cognition. Therefore, the aim of this study was to evaluate the association between sleep quality and performance of men and women in cognitive tests.

Material and Methods: After screening, 97 individuals with and without insomnia complaints participated of this study. Behavioral scales were evaluated using a number of instruments and the sleep pattern was recorded by actigraph. Subsequently, the participants were submitted to visuospatial/verbal working memory (WM), visual attention, and psychomotor vigilance tests (PVT).

Results: The actigraphic recordings indicated that men sleep later (d=-0.56, p<0.05), fall asleep faster (d=0.42, p<0.05), showed shorter sleep duration (d=0.53, p<0.05), and more sleep fragmentation than women (d=-0.41, p<0.05). The performance in the cognitive tasks also showed sex differences: the men showed better performance in the visuospatial short-term memory (d=-0.78, p<0.05); verbal (d=-0.61, p<0.05), and visuospatial-WM tests (d=-0.84, p<0.05); they also responded faster in the PVT (d=0.69, p<0.05), although made more mistakes (d=-0.85, p<0.01). Longer sleep latency was associated with poor performance in visual attention (r=0.52, p<0.05) and verbal memory tasks (r=-0.30, p<0.05) in men.

Conclusion: Our results suggest that difficulty in falling asleep was associated with cognitive impairment, especially in men. Sex differences in sleep quality and cognitive skills should be taken into account in future research in this field.
Social outbreak and its association with insomnia and daytime sleepiness in Chile
Authors: Pizarro-Mena Rafael Andrés , Duran-Aguero Samuel , Silva Andrés
Published: May 2022

Objectives: To associate the effects of the social outbreak with insomnia and daytime sleepiness according to the distance from the riots.

Material and Methods: Cross-sectional analytical study; a non-probabilistic sampling was carried out at a national level. The Google Forms tool was used; a document was submitted using a national database. The instrument consisted of four sections: socio-demographic data, biopsychosocial symptoms, insomnia severity index (ISI), and the Epworth sleepiness scale (ESS). The data were analyzed using descriptive statistics and the zero-inflated negative binomial model.

Results: Of a total of 2,532 surveyed people, 29% were male; 43% was younger than 30 years old. The 50% of the sample suffers from sleepiness and 71% shows some type of insomnia. The marginal effects of the zero-inflated negative binomial model show that women, people aged 51 or older, who are neither studying a healthcare degree nor working in the healthcare sector, that are exposed to 4 or more hours per day to the news and that live in areas near or very near the riots, have significantly higher ISI (marginal effect 1.356, SE 0.381, p-value 0.000) and ESS scores (marginal effect 0.693, SE 0.320, p-value 0.030). To live/work in rioting areas has the greater marginal effect compared to other determinants. Finally, neither employment status nor educational level are associated with significant effects in the aforementioned scales.

Conclusion: The riots occurred during the social outbreak of October 2019 in Chile had an effect on insomnia and daytime sleepiness. Particularly, to live/work in rioting areas has the greater marginal effect compared to other determinants.
Investigating the sleep habits in individual and team-sport athletes using the Athlete Sleep Behavior Questionnaire and the Pittsburgh Sleep Quality Index
Authors: Driller Matthew W. , Suppiah Haresh , Rogerson David , Ruddock Alan , James Lachlan , Virgile Adam
Published: May 2022

Objectives: There is limited large-scale data on maladaptive sleep practices in elite adult athletes and their influence on sleep characteristics. This study aimed to identify differences in sleep behaviours between individual and team-sport athletes using two sleep questionnaires.

Material and Methods: 407 (237 male, 170 female) elite adult athletes across sixteen sports (9 individual-sports, 7 team-sports) completed the Athlete Sleep Behavior Questionnaire (ASBQ) and the Pittsburgh Sleep Quality Index (PSQI).

Results: Individual-sport athletes reported greater total sleep time and higher sleep efficiency than team-sport athletes (p<0.05, d=0.28-0.29). There were no differences between global scores for the PSQI, however, there was a difference between global scores for the ASBQ as well as multiple individual items from both questionnaires (p<0.05), indicating poorer behaviours in team-sport athletes.

Discussion: Team-sport athletes displayed more maladaptive pre-sleep behaviours and poorer sleep characteristics than individual-sport athletes.
Sleep quality impairments in schizophrenia and bipolar affective disorder patients continue during periods of remission: a case-controlled study
Authors: Hacimusalar Yunus , Karaaslan Ozgul , Misir Emre , Amuk Ozge Ceren , Hacimusalar Goknur
Published: May 2022

Objective: Bipolar disorder (BD) and schizophrenia are chronic psychiatric disorders in which sleep disorders are commonly seen. In mental disorders, residual symptoms may persist even if symptoms are greatly reduced overall. The aim of this study was to compare the sleep quality of schizophrenia and BD patients in remission with that of healthy controls.

Methods: Forty-three patients with schizophrenia, 46 BD patients in remission for at least 3 months, and 51 healthy controls were included the study. The Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI), Young Mania Rating Scale (YMRS) and Pittsburgh Sleep Quality Index (PSQI) were administered to all participants and the Positive and Negative Syndrome Scale (PANSS) was administered to patients with schizophrenia.

Results: Poor sleep quality was more frequent in the patient groups than the control group (p=0.009). PSQI score was positively correlated with duration of disease (r=0.236; p=0.026), number of cigarettes smoked per day (r=0.430; p<0.001), body mass index (r=0.189; p=0.025), and negatively correlated with duration of remission (r=-0.224; p=0.0359).

Conclusion: Schizophrenia and BD patients in remission had worse sleep quality than a control group. Sleep quality was worst in the patients with schizophrenia. The severity of sleep disorder symptoms was positively associated with disease duration and negatively associated with duration of remission. Schizophrenia and BD patients should be carefully evaluated for symptoms of sleep disorders even when they are in clinical remission and should be offered additional treatment for sleep disorder symptoms when necessary.
O exercício de Albers como propulsor da experiência de Dewey
Authors:   Udesc, Mello Adriane Cristine Kirst Andere de
Published: May 2022

O exercício de Albers como propulsor da experiência de Dewey
Experiência, percepção e pedagogia da cor
Authors:   UEL/UDESC, Siqueira Juliano
Published: May 2022

Experiência, percepção e pedagogia da cor
Análisis estadístico de los homicidios dolosos y asesinatos juzgados por la Audiencia Provincial de Murcia desde 2007 hasta 2017
Authors: Pérez Bastida José Antonio
Published: May 2022

En el presente trabajo se analizan estadísticamente las sentencias de homicidios dolosos y asesinatos juzgados por la Audiencia Provincial de Murcia desde el año 2007 hasta el 2017. El estudio permite conocer con exactitud, para el periodo donde tuvieron lugar los hechos juzgados (1998-2017), el número de asesinatos y homicidios dolosos, su grado de consumación, el municipio donde sucedieron los hechos, el tiempo promedio de resolución de un caso para cada año y para todo el periodo, el sexo del autor, el sexo de la víctima, la nacionalidad del autor, la edad del autor, las penas de prisión impuestas, la existencia o inexistencia de relación previa entre autor y víctima, el detonante principal de los delitos, las armas empleadas, y los meses, días, horas y lugares de comisión más frecuentes.
Transmisión de las participaciones en la empresa familiar a la luz del Impuesto sobre Sociedades
Authors: Martínez Jiménez Francisco Jesús
Published: May 2022

Nowadays, we are in an environment where most of the companies, situated in Spain and Europe, are small and medium enterprises, which are family owned. Therefore, motivates to analyze all those operations that involve a transfer of the ownership of the family business, based on the Merger Tax Directive and the Spanish tax regulations. This situation has to be treated from this analysis and the point of view of the tax regulation system as well as every corporate restructuring opportunities or right to inheritance. Nevertheless, it is important to underline that this approach has as purpose to establish and optimize the limits of any tax charge arising due to any transaction. Regarding to that, it is necessary to use a correct analysis of the European Union law and of the ECJ case law.

Nos encontramos ante una situación donde la mayoría de las empresas que existen, tanto en España como en Europa, son empresas PYMES y con un marcado carácter familiar. Esta circunstancia, motiva a analizar todas aquellas operaciones que supongan una transmisión de la titularidad de la empresa familiar, en base a la Directiva fiscal de fusiones y la normativa fiscal española. Debiéndose plantear, en ese análisis y desde la perspectiva tributaria, la posibilidad de que se generen oportunidades fiscales en las operaciones de reestructuración o sucesión empresarial. Dicho planteamiento tiene como finalidad establecer los límites a las operaciones de optimización de la carga fiscal. Por ello, además, no se puede olvidar que se debe realizar un correcto análisis del Derecho de la UE y de la jurisprudencia del TJUE sobre el asunto.
Ayudas previas a la jubilación ordinaria. El caso de Navantia. Propuesta de aplicación al sector financiero
Authors: Flores Alcázar José
Published: May 2022

Undoubtedly the financial sector is the sector paradigm that systematically resorts to the pre-retirement of its older workers, particularly since the economic and financial crisis of 2007 until now. This is a sector in continuous conversion through an incessant merger process. Due to Covid-19 pandemic and the economic crisis caused by it, the sector faces a dizzying new process of concentration, in which thousands of jobs will again be lost. Pre-retirement needs to be incorporated into the labour system as one more Social Security benefit, legislating on the figure of the ERE and supplemented by recourse to RD 3/2014 of 10th January. Once the access of the undertakings to this resource has been regulated, the necessary maintenance of employment will be achieved, as the re-release contract would be an essential requirement for each early-retired worker to obtain this benefit.

El sector financiero constituye, sin duda, el paradigma de sector que, sistemáticamente recurre a la prejubilación de sus trabajadores de mayor edad, lo que viene haciendo especialmente desde la crisis económica y financiera de 2007 hasta ahora. Se trata de un sector en continua reconversión mediante un incesante proceso de fusiones. Con motivo de la pandemia de la Covid-19 y, la crisis económica provocada por esta, el sector afronta un nuevo y vertiginoso proceso de concentración, en el que nuevamente se perderán miles de puestos de trabajo. Es necesario que, la prejubilación, se incorpore al ordenamiento laboral como una prestación más de Seguridad Social, legislando sobre la figura del ERE, complementada con el recurso a lo dispuesto en el RD 3/2014, de 10 de enero. Una vez regulado el acceso de las empresas a este recurso, se conseguirá el necesario mantenimiento del empleo, pues el contrato de relevo seria requisito imprescindible para cada trabajador que se prejubile acogido a la prestación.
A case of maturity-onset diabetes of the young type 4 in Korea
Authors: Park Geu-Meum , Lee Soojung , Seo Ja Young , Lim Kyung In
Published: May 2022

Maturity-onset diabetes of the young (MODY) is a rare, autosomal dominant disease characterized by non-ketogenic diabetes mellitus (DM). MODY type 4, caused by PDX1 mutation, is a very rare subtype of MODY, especially in Korea. We report a case of a 10-year-old, nonobese girl with a family history of type 2 DM. After diagnosis, the patient’s serum glucose level was well controlled using metformin monotherapy; however, the glycated hemoglobin level increased to 9.0% approximately 2 years after treatment. No obesity or lifestyle problems were observed, and serum fasting C-peptide level was within the normal range. Furthermore, no islet-related autoantibodies were detected. A genetic screening for MODY using a next-generation sequencing panel was performed, and a likely heterozygous pathogenic PDX1 mutation (p.Gly246ArgfsTer21) was identified. The PDX1 variant was not detected in her mother, implying that the mutation had arisen de novo in the proband. She was prescribed insulin degludec in addition to metformin therapy, which improved her hyperglycemia. This report presents a novel MODY type 4 phenotype and highlights the importance of genetic screening in patients with MODY characteristics.
Research on the construction of characteristic industrial colleges in Application-oriented Colleges Based on the integration of industry and education
Authors:   Shenyang Urban Construction College,Shenyang,110167, GUO Chunlei , ZHAO Zhonghua ,   Shenyang Urban Construction College,Shenyang,110167, QI Qinghui ,   Shenyang Urban Construction College,Shenyang,110167, WANG Gang ,   Guangzhou Nanfang surveying and Mapping Technology Company,Shenyang,110061
Published: May 2022

Deepening the integration of industry and education, school enterprise cooperation and building a community of school enterprise destiny is the only way for application-oriented colleges to achieve high-quality development. As a new organizational form of industry and education integration, industrial college can effectively promote the organic connection of education chain, talent chain, industrial chain and innovation chain. It is a booster, converter and incubator for building a community of school enterprise destiny. Colleges and universities can realize the cultivation of high-quality applied talents by innovating the collaborative education mode of industry education integration.
Developing agricultural and forestry college students’ capacity for innovation, practice, and comprehensive quality in off-campus class-industry-practice
Authors:   China Agricultural University, Beijing, 100083, China, MA Shaochun , Bai Jing , Xing Haonan , Hu Jiwei , Li Weijing , Qian Jun , Xin Yujian
Published: May 2022

In terms of the engineering students in agricultural and forestry colleges, the off-campus class-industry-practice were discussed in this paper based on the existing problems in higher education innovation. It is meaningful to develop students’ capacity for innovation, practice, and comprehensive quality.
Development and Evaluation of Hybrid FBG Sensors and WDM-PON Fiber Optical Systems
Authors: Seņkāns Uģis
Published: May 2022

With the development of fiber optical data transmission technologies and infrastructure on a global scale, the use of fiber optical sensors to perform sensing functions is becoming increasingly important mainly due to their advantages, such as small size, light weight, multiplexing capabilities and others. Therefore, in order to ensure more efficient use of optical sensor technologies, it is necessary to research and search for new solutions for the integration and use of fiber optical sensors in existing and future fiber optical communication system architecture. The main goal of the Doctoral Thesis is to study and evaluate the interaction of FBG fiber optical sensor networks and WDM-PON metro-access transmission systems implemented in a single system with theoretical and experimental research. In order to evaluate their performance in a unified system, a detailed study of the interaction between the FBG optical sensor network and the fiber optic data transmission system has been performed by implementing mathematical modeling and experimental development of such systems.
Selected Topics in Digital Business Systems Research: Editorial Introduction to Issue 30 of CSIMQ
Authors: Lupeikiene Audrone , Saddiqa Mubashrah
Published: May 2022

The 30th issue of CSIMQ includes four articles that cover research problems in the field of digital business systems. Two of the selected articles are systematic literature reviews, while the other two provide methodological additions to the theory. Systematic literature reviews focus on conceptual modeling for the digital business ecosystems development life cycle and on deep learning methods for retail sales forecasting. The other two articles discuss the methodological and technological aspects of the developing digital models of cyber-physical systems and of the solving heat loss calculation problem.
On the organization of sound space in "The Tidings brought by Mary" by Paul Claudel, 1912 edition
Authors: Azarova Valentina Vladimirovna
Published: May 2022

The article examines the words and the meaning, as well as the dramaturgy of sound in the first edition of the mystery "The Tidings brought by Mary" by Paul Claudel. Understanding the synthesis of verbal and vocal intonation leads the author of the article to discover new ways of solving the problem of stage music in mystery drama by Claudel. The discrete nature of the design of the sound space of the mystery in the first edition represents the concept of separately performed fragments, in which the episodes integrated into the action in liturgical Latin are united by a common spiritual meaning. At the same time, the design of the sound space in the 2nd scene of Act III (the dramatic climax, the sacred space of the mystery) is characterized by novelty. Based on the interaction of theatrical-dramatic and musical structural elements, the composition of the scene is subordinated to the principle of end-to-end, continuous vocal-dramatic development of the action. Conclusions are drawn: during the 1910s, Claudel's idea of music in mystery drama was transformed - instead of musical fragments of an "applied" nature, a new compositional idea of stage music arose. The lyrical intonation of the author's voice is found in the sound space of the work. The mirror of Claudel's mystery reflects the principles of sound design of dramatic productions of traditional Japanese theater (Bunraku, Kabuki, Noh), as well as images of poetry of China and Japan. In the sound of the "The Tidings brought to Mary", the semantic and dramatic functions are performed by the verses of the songs "Oriole sings" and "Margarita, clear May!" performed by children's voices. Claudel's mystery drama formed a new understanding of the universal meaning of the mystery in the twentieth century.
Early learning of English in a Kazakh school (results of a sociolinguistic study)
Authors: Sulkarnayeva Assiya
Published: May 2022

The paper analyzes the situation of early learning of English in a Kazakh school. The author describes the results of the conducted sociolinguistic research in the capital gymnasium; analyzes the advantages and disadvantages of the introduced system of early English language teaching; justifies the need for a large-scale statistical study of the current situation. The author introduces the term "kazinglish" by analogy with the already established term "runglish" and justifies its relevance for further research in a comparative aspect. The object of the study is teaching English in Kazakhstan primary and secondary schools. The subject of the study is the data obtained from the survey of informants (anonymous cluster survey). В В В  Main conclusions: 1) change of one of the main mental and cultural paradigms in the field of foreign language education: focus on intercultural communication in action. 2) Primary and secondary level students identify motivation, professional competence of the teacher, accessibility, visibility as the main criteria for easy mastering of a foreign language. We conclude that there is a positive methodology for teaching a foreign language in relation to academic results and the predominant role of the interactive learning format.3) It is not necessary to talk about the presence of a certain talent for languages.4) It is necessary to form specialized training of students in the profile: humanitarian or natural-mathematical. 5) The problem of substitution of concepts and the resulting problem of colloquial foreign language. The so-called "easy and fast" method of language acquisition is becoming increasingly popular. As a result, side effects are unacceptable phonetic, grammatical, lexical and stylistic errors. 6) A pseudo-dialect of the English language is actively being formed in Kazakhstan, let's call it "Kazinglish" by analogy with "Runglish". "Kazinglish" has already become a reality. It is necessary to conduct a large-scale (republican) study on the mastery of foreign languages by the population. The results will allow analyzing the paradigms and trends that have occurred in the study of foreign languages in the country, and outline plans for the development of foreign language education in Kazakhstan.
Features of the translation of modal verbs based on the novel "Little Women" by Louise May Olcott
Authors: Bednova Yulia Aleksandrovna
Published: May 2022

The article is devoted to the analysis of the translation of modal verbs in the novel "Little Women" by Louise May Alcott. The object of this research is the categories of modality in a work of art. The subject of the study is the ways of transferring modality from English to Russian when translating the novel "Little Women" by Louise May Alcott. The relevance of this work is due to the fact that the transfer of modality from English to Russian and vice versa presents certain difficulties for the majority of Russian-speaking students. The author considers the classification of modal verbs, as well as the meanings they acquire in the process of translating this literary text. В  The scientific novelty of the article is due to the need to study such a universal concept as modality, which in each case, depending on the communicative situation, conveys not only facts, but also evaluates what is happening. The article solves the following main tasks: to analyze the meanings of modal verbs and the frequency of their use in this work, as well as to present possible translation options. As a result, we found that modality presents difficulties in translation due to the fact that in various communicative situations it can acquire an additional emotional load, which, if misinterpreted, can distort the essence of the utterance.
Deconstructive repair of a traumatic vertebrovertebral arteriovenous fistula via a contralateral endovascular approach
Authors: Nageshwaran Sathiji K. , Deng Francis , Regenhardt Robert W. , Das Alvin S. , Alotaibi Naif M. , Patel Aman B. , Stapleton Christopher J.
Published: May 2022

Vertebrovertebral arteriovenous fistulas (VVAVFs) are rare entities that lack consensus guidelines for their management. Our case describes the successful treatment of a traumatic VVAVF via a contralateral deconstructive endovascular approach. A 64-year-old female presented following a traumatic fall. Computed tomography angiogram highlighted a 2 cm pseudoaneurysm of the right vertebral artery (VA) with epidural contrast enhancement and a hematoma with flow voids within the epidural space. Digital subtraction angiography showed a VVAVF at C2-3 with retrograde filling of the distal right VA. Having undergone several unsuccessful passes of the proximal dissection flap in the right VA, the patient underwent a contralateral deconstructive approach with correction of the VVAVF without complication. The remaining feeding branches had occluded after 1 week. The patient made a complete recovery without neurological sequelae at 3-month follow-up.
Quantum nonlocal test of “X” state based on geometric interpretation of CHSH inequality
Authors: Zeng Bai-Yun , Gu Peng-Yu , Hu Qiang , Jia Xin-Yan , Fan Dai-He ,   School of Physical Science and Technology, Southwest Jiaotong University, Chengdu 610031, China
Published: May 2022

Quantum nonlocal correlation is one of the important features that distinguish the quantum theory from classical theory. As a typical quantum mixed state, the study of quantum nonlocal correlation based on the “X” state is of great importance for the verification of the correctness of quantum theory and the application of quantum information theory. In this work, with the traditional Clauser-Horne-Shimony-Holt (CHSH) inequality testing for quantum nonlocal correlations, we propose a strategy for testing the quantum nonlocal correlations based on the geometric interpretation of the “X” state. By using the geometric interpretation of the “X” state, which is described by the transform of Bloch sphere, it is possible to investigate the optimal selection of measurement settings. The maximum value of CHSH inequalities can also obtained from the physical images. Finally, the range of parameters for a successful quantum nonlocal correlation testing based on the CHSH inequality for the “X” state is studied. The results show that when \begin{document}$f = 1$\end{document}, the “X” state will be reduced to a normal pure entangled state, and the quantum nonlocal correlation testing results are in full agreement with the traditional ones. This result proves the correctness of the geometric interpretation strategy proposed in this work. When\begin{document}$f \lt 1$\end{document}, only some of the “X” states can be used for e successfully testing the quantum nonlocal correlations. It is also found that the range of fidelity values that can successfully test the quantum nonlocal correlations will be further increased by increasing the values of r. In particular, when r = 1, the range of fidelity value will reach a largest one (e.g. \begin{document}$f \gt 0.781$\end{document}). The results in this work can provide the reference for experimentally testing the quantum nonlocal correlation by using the “X” state.
Development of three-port fiber-coupled vapor cell probe and its application in microwave digital communication
Authors: Lin Yi , Wu Feng-Chuan , Mao Rui-Qi , Yao Jia-Wei , Liu Yi , An Qiang , Fu Yun-Qi ,   College of Electronic Science, National University of Defense Technology, Changsha 410073, China
Published: May 2022

The quantum microwave measurement technology based on Rydberg atoms has developed rapidly and received widespread attention. It has shown significant advantages such as probe size independent of wavelength and broad spectrum measurement. Fiber-coupled vapor cell probe is one of the key technologies for portable quantum microwave measurement systems. The existing two-port fiber-coupled probe shares the graded index (GRIN) lens and optical fibers for outputting detection light with inputting coupling light, which limits light transmission efficiency of the detection light to 17%. Under these conditions, the power of the inputting detection light must be increased to ensure sufficient power to output the detection light, causing the electromagnetically-induced transparency (EIT) spectrum to broaden to 11 MHz, ultimately resulting in reduced measurement sensitivity. In this work, we propose a three-port fiber-coupled atomic gas chamber probe with an integrated dichroic mirror. On condition that the detection light and coupling light are transmitted in opposite directions and overlap in the vapor cell, the outgoing detection light is separated into two beams; one goes to an individual GRIN lens and the other to the output fiber, and the detection light transmission efficiency is 40.4%, and the half-height width of the EIT spectrum is reduced to 6 MHz. The probe is used to measure the microwave electric field intensity and phase; its effectiveness is verified by its ability to receive QPSK, 16QAM digitally modulated signals.
Photoacoustic simultaneous detection of multiple trace gases for industrial park application
Authors: Liu Li-Xian , Chen Bai-Song , Zhang Le , Zhang Xue-Shi , Huan Hui-Ting , Yin Xu-Kun , Shao Xiao-Peng , Ma Yu-Fei , Mandelis Andreas ,   School of Optoelectronic Engineering, Xidian University, Xi’an 710071, China,   Department of Mechanical and Industrial Engineering, University of Toronto, Toronto M5S 3G8, Canada,   National Key Laboratory of Science and Technology on Tunable Laser, Harbin Institute of Technology, Harbin 150001, China
Published: May 2022

The determination of toxic or harmful gases in industrial parks is a challenge to monitoring exhaust contaminants due to the features of complex compositions and ubiquity. Blackbody sources play an important role in simultaneously detecting the multiple gas species in the presence of cross-interfering absorption lines due to their effective ultra-wide wavelength range. Nevertheless, the problem of lower intensity per wavelength and less stability persists as an obstacle for highly sensitive trace gas detection. In this study, a dual optical path (DOP) enhanced differential photoacoustic and spectral detection mode is developed for simultaneously detecting the multiple toxic or harmful gas through augmenting the weak effective absorption signals and suppressing the spurious coherent background noise. Two identical T-type photoacoustic resonators are introduced to enable the differential mode. Neverthelss, the pure optical approach cannot distinguish the absorption characteristics of acetylene (C2H2) with volume fraction 5 × 10–5 even with the DOP enhancement, whereas emerging peaks in the differential photoacoustic (PA) mode reveal the capability of PA spectroscopy to suppress coherent noise. The results demonstrate that the differential PA signal is improved by 1.91 times that obtained by the DOP design. Methane (NH3), acetylene (C2H2) and carbon dioxide (CO2) are used to verify the performance of this DOP enhanced differential PA gas sensor, and the volume fraction of the sensitivity is found to be 7.25 × 10–7 for CO2, 1.84 × 10–6 for C2H2, and 1.43 × 10–6 for NH3 at standard temperature and pressure, which is an order of magnitude higher than the original single mode PA value. Linear PA amplitude responses ranging from 0 to 3 × 10–3 in volume fraction with respect to the three target gases are observed, and the correction coefficients are all greater than 0.995. The DOP enhanced differential PA detection mode compensates for the weakness of the limited sensitivity associated with broadband spectroscopic methods based on blackbody radiator. Thus, the broadband DOP enhanced differential photoacoustic modality is demonstrated to be an effective approach to simultaneous, highly sensitive and selective detection of multiple trace gases.
Transcription elongation is finely tuned by dozens of regulatory factors
Authors: Couvillion Mary , Harlen Kevin M , Lachance Kate C , Trotta Kristine L , Smith Erin , Brion Christian , Smalec Brendan M , Churchman L Stirling
Published: May 2022

Understanding the complex network that regulates transcription elongation requires the quantitative analysis of RNA polymerase II (Pol II) activity in a wide variety of regulatory environments. We performed native elongating transcript sequencing (NET-seq) in 41 strains of Saccharomyces cerevisiae lacking known elongation regulators, including RNA processing factors, transcription elongation factors, chromatin modifiers, and remodelers. We found that the opposing effects of these factors balance transcription elongation and antisense transcription. Different sets of factors tightly regulate Pol II progression across gene bodies so that Pol II density peaks at key points of RNA processing. These regulators control where Pol II pauses with each obscuring large numbers of potential pause sites that are primarily determined by DNA sequence and shape. Antisense transcription varies highly across the regulatory landscapes analyzed, but antisense transcription in itself does not affect sense transcription at the same locus. Our findings collectively show that a diverse array of factors regulate transcription elongation by precisely balancing Pol II activity.
Malformations in Late Devonian brachiopods from the western Junggar, NW China and their potential causes
Authors: Zong Ruiwen , Gong Yiming
Published: May 2022

Although malformations are found in both extant organisms and the fossil record, they are more rarely reported in the fossil record than in living organisms, and the environmental factors causing the malformations are much more difficult to identify for the fossil record. Two athyrid brachiopod taxa from the Upper Devonian Hongguleleng Formation in western Junggar (Xinjiang, NW China) show distinctive shell malformation. Of 198 Cleiothyridina and 405 Crinisarina specimens, 18 and 39 individuals were malformed, respectively; an abnormality ratio of nearly 10%. Considering the preservation status and buried environment of the abnormal specimens, and analysis of trace elements and rare earth elements from whole-rock and brachiopod shells, we conclude that the appearance of malformed athyrids is likely related to epi/endoparasites, or less likely the slightly higher content of heavy metal in the sea.