bluuebunny/crossref_metadata_2025 huggingface dataset:
Gaining Institutional Permission: Researching Precarious Legal Status in Canada
Authors: Bernhard Judith K. , Young Julie E. E.
Published: July 2021

There is limited research into the situations of people living with precarious status in Canada, which includes people whose legal status is in-process, undocumented, or unauthorized, many of whom entered the country with a temporary resident visa, through family sponsorship arrangements, or as refugee claimants. In 2005, a community-university alliance sought to carry out a research study of the lived experiences of people living with precarious status. In this paper, we describe our negotiation of the ethics review process at a Canadian university and the ethical, legal, and methodological issues that emerged. Although being able to guarantee our participants complete confidentiality was essential to the viability of the project due to their vulnerability to detention or deportation, we discovered that the Canadian legal framework limited us to being able to offer them confidentiality “to the fullest extent possible by law.” One way to overcome this conflict would have been through the construction of a Wigmore defence, in which we would document that the research would not be possible without assurance of our participants’ confidentiality. Such a defence would be tested in court if our research records were subpoenaed by immigration enforcement authorities. Rather than take the risk that this defence would not be successful and would result in our participants being deported, we altered the research methods from using multiple interviews to establish trust (which would have required that we store participants’ contact information) to meeting participants only once to discuss their experiences of living with precarious legal status in Canada. Our encounter with the ‘myth of confidentiality’ raised questions about the policing of knowledge production.
The trainees' perspective on developing an end-of-grant knowledge translation plan
Authors: Leung Brenda M. Y. , Catallo Cristina , Riediger Natalie D. , Cahill Naomi E. , Kastner Monika
Published: July 2021

BACKGROUND: Knowledge translation (KT) is a rapidly growing field that is becoming an integral part of research protocols.
METHODS: This meeting report describes one group's experience at the 2009 KT Canada Summer Institute in developing an end-of-grant KT plan for a randomized control trial proposal.

RESULTS: Included is a discussion of the process, challenges and recommendations from the trainee's perspective in developing an end-of-grant KT plan.

CONCLUSION: New researchers should consider developing an end-of-grant KT plan with strategies that move beyond passive dissemination to incorporate innovative means of collaboration with the end user to craft the message, package the information and share the research findings with end users.
Evaluating Web-based Static, Animated, and Interactive Maps for Injury Prevention
Authors: Cinnamon Jonathan , Rinner Claus , Cusimano Michael D. , Marshall Sean , Bekele Tsegaye , Hernandez Tony , Glazier Richard H. , Chipman Mary L.
Published: July 2021

Public health planning can benefit from visual exploration and analysis of geospatial data. Maps and geo-visualization tools must be developed with the user-group in mind. User-needs assessment and usability testing are crucial elements in the iterative process of map design and implementation. This study presents the results of a usability test of static, animated and interactive maps of injury rates and socio-demographic determinants of injury by a sample of potential end-users in Toronto, Canada. The results of the user-testing suggest that different map types are useful for different purposes and for satisfying the varying skill level of the individual user. The static maps were deemed to be easy to use and versatile, while the animated maps could be made more useful if animation controls were provided. The split-screen concepts of the interactive maps was highlighted as particularly effective for map comparison. Overall, interactive maps were identified as the preferred map type for comparing patterns of injury and related socio-demographic risk factors. Information collected from the user-tests is being used to expand and refind the injury webmaps for Toronto, and could inform other public health-related geo-visualization projects.
Investigative advising: a job for Bayes
Authors: Allen Jared C.
Published: July 2021

Background: Bayesian approaches to police decision support offer an improvement upon more commonly used statistical approaches. Common approaches to case decision support often involve using frequencies from cases similar to the case under consideration to come to an isolated likelihood that a given suspect either a) committed the crime or b) has a given characteristic or set of characteristics. The Bayesian approach, in contrast, offers formally
contextualized estimates and utilizes the formal logic desired by investigators.

Findings: Bayes’ theorem incorporates the isolated likelihood as one element of a three-part equation, the other parts being 1) what was known generally about the variables in the case prior to the case occurring (the scientific-theoretical priors) and 2) the relevant base rate information that contextualizes the evidence obtained (the event context). These elements are precisely the domain of decision support specialists (investigative advisers),
and the Bayesian paradigm is uniquely apt for combining them into contextualized estimates for decision support.

Conclusions: By formally combining the relevant knowledge, context, and likelihood, Bayes’ theorem can improve the logic, accuracy, and relevance of decision support statements.
Lesser of Two Evils? Foraging Choices in Response to Threats of Predation and Parasitism
Authors: Koprivnikar Janet , Penalva Laura
Published: July 2021

Predators have documented post-encounter (density-mediated) effects on prey but their pre-encounter impacts, including behavioural alterations, can be substantial as well. While it is increasingly evident that this “ecology of fear” is important to understand for natural enemy-victim relationships, fear responses of hosts to the threat of infection by a parasite are relatively unknown. We examined larval amphibian (Lithobates pipiens) foraging choices by experimentally manipulating the presence of cues relating to predator (larval odonate) or parasite (the trematode Ribeiroia ondatrae) threats. Tadpoles avoided foraging where predator or parasite cues were present; however, they did not treat these as equal hazards. When both threats were simultaneously present, tadpoles strongly preferred to forage under the threat of parasitism compared to predation, likely driven by their relative lethality in our study. Our results indicate that altered spatial use is an important anti-parasite behaviour, and demonstrate that parasite avoidance can affect foraging in a manner similar to predators, warranting greater study of the pre-encounter effects of this enemy type.
Proteomic Analysis of the Secretome of Cellulomonas fimi ATCC 484 and Cellulomonas flavigena ATCC 482
Authors: Wakarchuk Warren W. , Brochu Denis , Foote Simon , Robotham Anna , Saxena Hirak , Erak Tamara , Kelly John
Published: July 2021

The bacteria in the genus Cellulomonas are known for their ability to degrade plant cell wall biomass. Cellulomonas fimi ATCC 484 and C. flavigena ATCC 482 have been the subject of much research into secreted cellulases and hemicellulases. Recently the genome sequences of both C. fimi ATCC 484 and C. flavigena ATCC 482 were published, and a genome comparison has revealed their full spectrum of possible carbohydrate-active enzymes (CAZymes). Using mass spectrometry, we have compared the proteins secreted by C. fimi and C. flavigena during growth on the soluble cellulose substrate, carboxymethylcellulose (CMC), as well as a soluble xylan fraction. Many known C. fimi CAZymes were detected, which validated our analysis, as were a number of new CAZymes and other proteins that, though identified in the genome, have not previously been observed in the secretome of either organism. Our data also shows that many of these are co-expressed on growth of either CMC or xylan. This analysis provides a new perspective on Cellulomonas enzymes and provides many new CAZyme targets for characterization.
Energy Solutions, Neo-Liberalism, and Social Diversity in Toronto, Canada
Authors: Teelucksingh Cheryl , Poland Blake
Published: July 2021

In response to the dominance of green capitalist discourses in Canada’s environmental movement, in this paper, we argue that strategies to improve energy policy must also provide mechanisms to address social conflicts and social disparities. Environmental justice is proposed as an alternative to mainstream environmentalism, one that seeks to address systemic social and spatial exclusion encountered by many racialized immigrants in Toronto as a result of neo-liberal and green capitalist municipal policy and that seeks to position marginalized communities as valued contributors to energy solutions. We examine Toronto-based municipal state initiatives aimed at reducing energy use while concurrently stimulating growth (specifically, green economy/green jobs and ‘smart growth’). By treating these as instruments of green capitalism, we illustrate the utility of environmental justice applied to energy-related problems and as a means to analyze stakeholders’ positions in the context of neo-liberalism and green capitalism, and as opening possibilities for resistance.
Spatial Patterns of Urban Wastewater Discharge and Treatment Plants Efficiency in China.
Authors: An Min , He Weijun , Degefu Dagmawi Mulugeta , Liao Zaiyi , Zhang Zhaofang , Yuan Liang
Published: July 2021

With the rapid economic development, water pollution has become a major concern in China. Understanding the spatial variation of urban wastewater discharge and measuring the efficiency of wastewater treatment plants are prerequisites for rationally designing schemes and infrastructures to control water pollution. Based on the input and output urban wastewater treatment data of the 31 provinces of mainland China for the period 2011–2015, the spatial variation of urban water pollution and the efficiency of wastewater treatment plants were measured and mapped. The exploratory spatial data analysis (ESDA) model and super-efficiency data envelopment analysis (DEA) combined Malmquist index were used to achieve this goal. The following insight was obtained from the results. (1) The intensity of urban wastewater discharge increased, and the urban wastewater discharge showed a spatial agglomeration trend for the period 2011 to 2015. (2) The average inefficiency of wastewater treatment plants (WWTPs) for the study period was 39.2%. The plants’ efficiencies worsened from the eastern to western parts of the country. (3) The main reasons for the low efficiency were the lack of technological upgrade and scale-up. The technological upgrade rate was −4.8%, while the scale efficiency increases as a result of scaling up was −0.2%. Therefore, to improve the wastewater treatment efficiency of the country, the provinces should work together to increase capital investment and technological advancement.
Impact of the H275Y and I223V Mutations in the Neuraminidase of the 2009 Pandemic Influenza Virus In Vitro and Evaluating Experimental Reproducibility
Authors: Beauchemin Catherine A. A. , Paradis Eric G. , Pinilla Lady Tatiana , Holder Benjamin P. , Abed Yacine , Boivin Guy
Published: July 2021

The 2009 pandemic H1N1 (H1N1pdm09) influenza virus is naturally susceptible to neuraminidase (NA) inhibitors, but mutations in the NA protein can cause oseltamivir resistance. The H275Y and I223V amino acid substitutions in the NA of the H1N1pdm09 influenza strain have been separately observed in patients exhibiting oseltamivir-resistance. Here, we apply mathematical modelling techniques to compare the fitness of the wild-type H1N1pdm09 strain relative to each of these two mutants. We find that both the H275Y and I223V mutations in the H1N1pdm09 background significantly lengthen the duration of the eclipse phase (by 2.5 h and 3.6 h, respectively), consistent with these NA mutations delaying the release of viral progeny from newly infected cells. Cells infected by H1N1pdm09 virus carrying the I223V mutation display a disadvantageous, shorter infectious lifespan (17 h shorter) than those infected with the wild-type or MUT-H275Y strains. In terms of compensating traits, the H275Y mutation in the H1N1pdm09 background results in increased virus infectiousness, as we reported previously, whereas the I223V exhibits none, leaving it overall less fit than both its wild-type counterpart and the MUT-H275Y strain. Using computer simulated competition experiments, we determine that in the presence of oseltamivir at doses even below standard therapy, both the MUT-H275Y and MUT-I223V dominate their wild-type counterpart in all aspects, and the MUT-H275Y outcompetes the MUT-I223V. The H275Y mutation should therefore be more commonly observed than the I223V mutation in circulating H1N1pdm09 strains, assuming both mutations have a similar impact or no significant impact on between-host transmission. We also show that mathematical modelling offers a relatively inexpensive and reliable means to quantify inter-experimental variability and assess the reproducibility of results.
Evaluation of the acceptability of a CD-ROM as a health promotion tool for Inuit in Ottawa
Authors: McShane Kelly , Smylie Janet K. , Hastings Paul D. , Prince Conrad , Siedule Connie
Published: July 2021

Background

There are few health promotion tools for urban Inuit, and there is a specific dearth of evaluations on such tools.

Objective

The current study used a community-specific approach in the evaluation of a health promotion tool, based on an urban Inuit community’s preferences of health knowledge sources and distribution strategies. In partnership with the Tungasuvvingat Inuit Family Health Team in Ottawa, a CD-ROM was developed featuring an Inuk Elder presenting prenatal health messages in both Inuktitut and English. Also, relevant evaluation materials were developed.

Design

Using a mixed methods approach, 40 participants completed interviews prior to viewing the CD-ROM and participated in a focus group at follow-up. Questionnaires were also completed pre- and post-viewing to assess changes between expectations and reactions in order to document acceptability.

Results

Significant increases were found on satisfaction, acceptability of medium and relevance of content ratings. Qualitative findings also included (a) interest, uncertainty and conditional interest prior to viewing; and (b) positive evaluations of the CD-ROM.

Conclusions

This suggests that CD-ROM technology has the potential for health promotion for urban Inuit, and the community-specific evaluation approach yielded useful information.
A finite element formulation for bending-torsion coupled vibration analysis of delaminated beams under combined axial load and end moment
Authors: Kashani Mir Tahmaseb , Hashemi Seyed Mohammad
Published: July 2021

Free vibration analysis of beams with single delamination undergoing bending-torsion coupling is made, using traditional finite element technique. The Galerkin weighted residual method is applied to convert the coupled differential equations of motion into to a discrete problem, where, in addition to the conventional mass and stiffness matrices, a delamination stiffness matrix, representing the extra stiffening effects at the delamination tips, is introduced. The linear eigenvalue problem resulting from the discretization along the length of the beam is solved to determine the frequencies and modes of free vibration. Both “free mode” and “constrained mode” delamination models are considered in formulation, and it is shown that the continuity (both kinematic and force) conditions at the beam span-wise locations corresponding to the extremities of the delaminated region, in particular, play a great role in “free mode” model formulation. Current trends in the literature are examined, and insight into different types of modeling techniques and constraint types are introduced. In addition, the data previously available in the literature and those obtained from a finite element-based commercial software are utilized to validate the presented modeling scheme and to verify the correctness of natural frequencies of the systems analyzed here. The paper ends with general discussions and conclusions on the presented theories and modeling approaches.
Childhood and family influences on body mass index in early adulthood: findings from the Ontario Child Health Study
Authors: Gonzalez Andrea , Boyle Michael H. , Georgiades Katholiki , Duncan Laura , Atkinson Leslie , MacMillan Harriet L.
Published: July 2021

Background
Overweight and obesity are steadily increasing worldwide with the greatest prevalence occurring in high-income countries. Many factors influence body mass index (BMI); however multiple influences assessed in families and individuals are rarely studied together in a prospective design. Our objective was to model the impact of multiple influences at the child (low birth weight, history of maltreatment, a history of childhood mental and physical conditions, and school difficulties) and family level (parental income and education, parental mental and physical health, and family functioning) on BMI in early adulthood.

Methods
We used data from the Ontario Child Health Study, a prospective, population-based study of 3,294 children (ages 4–16 years) enrolled in 1983 and followed up in 2001 (N = 1,928; ages 21–35 years). Using multilevel models, we tested the association between family and child-level variables and adult BMI after controlling for sociodemographic variables and health status in early adulthood.

Results
At the child level, presence of psychiatric disorder and school difficulties were related to higher BMI in early adulthood. At the family level, receipt of social assistance was associated with higher BMI, whereas family functioning, having immigrant parents and higher levels of parental education were associated with lower BMI. We found that gender moderated the effect of two risk factors on BMI: receipt of social assistance and presence of a medical condition in childhood. In females, but not in males, the presence of these risk factors was associated with higher BMI in early adulthood.

Conclusion
Overall, these findings indicate that childhood risk factors associated with higher BMI in early adulthood are multi-faceted and long-lasting. These findings highlight the need for preventive interventions to be implemented at the family level in childhood.
Musings on Collection Analysis and Its Utility in Modern Collection Development
Authors: Schmidt Jane
Published: July 2021

A commentary on moving views of collection analysis forward to focus more on access rather than ownership, and services rather than physical resources to measure the ability of a library to support academic programs of study.
Process evaluation of appreciative inquiry to translate pain management evidence into pediatric nursing practice
Authors: Kavanagh Tricia , Stevens Bonniue , Seers Kate , Sidani Souraya , Watt-Watson Judy
Published: July 2021

Background
Appreciative inquiry (AI) is an innovative knowledge translation (KT) intervention that is compatible with the Promoting Action on Research in Health Services (PARiHS) framework. This study explored the innovative use of AI as a theoretically based KT intervention applied to a clinical issue in an inpatient pediatric care setting. The implementation of AI was explored in terms of its acceptability, fidelity, and feasibility as a KT intervention in pain management.

Methods
A mixed-methods case study design was used. The case was a surgical unit in a pediatric academic-affiliated hospital. The sample consisted of nurses in leadership positions and staff nurses interested in the study. Data on the AI intervention implementation were collected by digitally recording the AI sessions, maintaining logs, and conducting individual semistructured interviews. Data were analysed using qualitative and quantitative content analyses and descriptive statistics. Findings were triangulated in the discussion.

Results
Three nurse leaders and nine staff members participated in the study. Participants were generally satisfied with the intervention, which consisted of four 3-hour, interactive AI sessions delivered over two weeks to promote change based on positive examples of pain management in the unit and staff implementation of an action plan. The AI sessions were delivered with high fidelity and 11 of 12 participants attended all four sessions, where they developed an action plan to enhance evidence-based pain assessment documentation. Participants labeled AI a 'refreshing approach to change' because it was positive, democratic, and built on existing practices. Several barriers affected their implementation of the action plan, including a context of change overload, logistics, busyness, and a lack of organised follow-up.

Conclusions
Results of this case study supported the acceptability, fidelity, and feasibility of AI as a KT intervention in pain management. The AI intervention requires minor refinements (e.g., incorporating continued follow-up meetings) to enhance its clinical utility and sustainability. The implementation process and effectiveness of the modified AI intervention require evaluation in a larger multisite study.
Cognitive Spectrum Sensing with Multiple Primary Users in Rayleigh Fading Channels
Authors: Al-Juboori Salam , Hussain Sattar J. , Fernando Xavier
Published: July 2021

Accurate detection of white spaces is crucial in cognitive radio networks. Initial investigations show that the accurate detection in a multiple primary users environment is challenging, especially under severe multipath conditions. Among many techniques, recently proposed eigenvalue-based detectors that use random matrix theories to eliminate the need of prior knowledge of the signals proved to be a solid approach. In this work, we study the effect of Rayleigh multipath fading channels on spectrum sensing in a multiple primary user environment for a pre-proposed detector called the spherical detector using the eigenvalue approach. Simulation results show interesting outcomes.
Color star tracking II: matching
Authors: McVittie Geoffrey R. , Enright John
Published: July 2021

A novel matching algorithm is presented that can identify stars using raw images of the sky obtained from a CMOS color filter array detector. The algorithm combines geometric information with amplitude ratios calculated from the red, green, and blue color color channels. Conventional algorithms that match stars based solely on inter-star geometry (and sometimes relative brightness), typically require three or more stars for a confident star match. In contrast, the presented algorithms are able to find matches with only two imaged stars in most regions of the sky. The necessary catalog preparation and a simple star-pair matching algorithm based on combined color intensity ratios and the angular spacing are discussed. Results from a large set of simulation trials and initial results from sensor field testing are presented.
Copyright 2013 Society of Photo‑Optical Instrumentation Engineers (SPIE). One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this publication for a fee or for commercial purposes, and modification of the contents of the publication are prohibited.
Re-Configurable Parallel Stream Processor with Self-Assembling and Self-Restorable Micro-Architecture
Authors: Kirischian Lev , Terterian Irina , Chun Pil Woo , Geurkov Vadim
Published: July 2021

In this paper we present a concept of the self-assembling micro-architectures of Application Specific Virtual Processors for data-stream processing. The procedure for micro-architecture assembling is developed for Xilinx "Virtex" FPGA devices. It is shown that proposed approach allows a minimization of system resources for multi-task data-stream workload and gives ability for self-restoration of processing micro-architectures when hardware fault occurs. This Paper presents a description of system level architecture of run-time re-configurable multi-stream parallel processor for video applications and results gained on the prototype.
Massive MIMO wireless networks: an overview
Authors: Hassan Noha , Fernando Xavier
Published: July 2021

Massive multiple-input-multiple-output (MIMO) systems use few hundred antennas to simultaneously serve large number of wireless broadband terminals. It has been incorporated into standards like long term evolution (LTE) and IEEE802.11 (Wi-Fi). Basically, the more the antennas, the better shall be the performance. Massive MIMO systems envision accurate beamforming and decoding with simpler and possibly linear algorithms. However, efficient signal processing techniques have to be used at both ends to overcome the signaling overhead complexity. There are few fundamental issues about massive MIMO networks that need to be better understood before their successful deployment. In this paper, we present a detailed review of massive MIMO homogeneous, and heterogeneous systems, highlighting key system components, pros, cons, and research directions. In addition, we emphasize the advantage of employing millimeter wave (mmWave) frequency in the beamforming, and precoding operations in single, and multi-tier massive MIMO systems.

Keywords: 5G wireless networks; massive MIMO; linear precoding; encoding; channel estimation; pilot contamination; beamforming; HetNets
Foucault's "fearless speech" and the transformation and mentoring of medical students
Authors: Papadimos Thomas J , Murray Stuart J
Published: July 2021

In his six 1983 lectures published under the title, Fearless Speech (2001), Michel Foucault developed the theme of free speech and its relation to frankness, truth-telling, criticism, and duty. Derived from the ancient Greek word parrhesia, Foucault's analysis of free speech is relevant to the mentoring of medical students. This is especially true given the educational and social need to
transform future physicians into able citizens who practice a fearless freedom of expression on
behalf of their patients, the public, the medical profession, and themselves in the public and political arena. In this paper, we argue that Foucault's understanding of free speech, or parrhesia, should be read as an ethical response to the American Medical Association's recent educational effort, Initiative to Transform Medical Education (ITME): Recommendations for change in the system of medical education (2007). In this document, the American Medical Association identifies gaps in medical education, emphasizing the need to enhance health system safety and quality, to improve education in training institutions, and to address the inadequacy of physician preparedness in new content areas. These gaps, and their relationship to the ITME goal of promoting excellence in patient care by implementing reform in the US system of medical education, call for a serious consideration and use of Foucault's parrhesia in the way that medical students are trained and mentored.
Re-imagining child and youth care practice with African Canadian youth
Authors: Daniel Beverly-Jean , Jean-Pierre Johanne
Published: July 2021

This article is based on a plenary held during the Child & Youth Care in Action VI Conference: Moving Through Trails and Trials Toward Community Wellness, held in Victoria, British Columbia in April 2019. It explores how we can re-imagine child and youth care practice with African Canadian youth. This emerging paradigm aligns with child and youth care politicized praxis as well as trauma-informed and strengths-based approaches in the field’s literature. We highlight the importance of mobilizing critical and transformative theoretical frameworks along with an Africentric worldview to substantially support youth of African descent with a strengths-based approach. Moreover, the protective role of Black-affirming spaces is developed and articulated.

Keywords: child and youth care (CYC), youth work, Black-affirming space, African Canadian, youth
Exploring the effect of biological delays in kinetic models of influenza within a host or cell culture
Authors: Holder Benjamin P , Beauchemin Catherine A. A.
Published: July 2021

Background
For a typical influenza infection in vivo, viral titers over time are characterized by 1–2 days of exponential growth followed by an exponential decay. This simple dynamic can be reproduced by a broad range of mathematical models which makes model selection and the extraction of biologically-relevant infection parameters from experimental data difficult.

Results
We analyze in vitro experimental data from the literature, specifically that of single-cycle viral yield experiments, to narrow the range of realistic models of infection. In particular, we demonstrate the viability of using a normal or lognormal distribution for the time a cell spends in a given infection state (e.g., the time spent by a newly infected cell in the latent state before it begins to produce virus), while exposing the shortcomings of ordinary differential equation models which implicitly utilize exponential distributions and delay-differential equation models with fixed-length delays.

Conclusions
By fitting published viral titer data from challenge experiments in human volunteers, we show that alternative models can lead to different estimates of the key infection parameters.
Optical coherence elastography: current status and future applications
Authors: Sun Cuiru , Standish Beau , Yang Victor X. D.
Published: July 2021

Optical coherence tomography (OCT) has several advantages over other imaging modalities, such as angiography and ultrasound, due to its inherently high in vivoresolution, which allows for the identification of morphological tissue structures. Optical coherence elastography (OCE) benefits from the superior spatial resolution of OCT and has promising applications, including cancer diagnosis and the detailed characterization of arterial wall biomechanics, both of which are based on the elastic properties of the tissue under investigation. We present OCE principles based on techniques associated with static and dynamic tissue excitation, and their corresponding elastogram image-reconstruction algorithms are reviewed. OCE techniques, including the development of intravascular- or catheter-based OCE, are in their early stages of development but show great promise for surgical oncology or intravascular cardiology applications.
Depression and anxiety during the perinatal period
Authors: Fairbrother Nichole , Young Allan H. , Janssen Patricia , Antony Martin M. , Tucker Emma
Published: July 2021

Background
Mood and anxiety and related disorders (AD) account for a significant proportion of mental health conditions, with close to 30 % of the population (28.8 %) suffering from an AD at some time in their life, and over fifteen percent (16.2 %) suffering from a mood disorder. The existing empirical literature leaves a number of important gaps with respect to our understanding of mood, anxiety and stress related difficulties among pregnant and postpartum women. The objective of this research is to address these.

Methods
Participants were 660 English-speaking pregnant women. Participants for the portion of the research estimating the prevalence/incidence of perinatal mood disorders and AD (N = 347) were recruited proportionally from a geographically defined area. All participants were recruited via prenatal clinic visits at hospitals, physician offices and midwifery clinics, and via community outreach at events and through word of mouth. Recruitment took place between November 9, 2007 and November 12, 2010. Participants were administered questionnaires prenatally at two time points (approximately 24 and 33 weeks gestation) and again at 4–6 weeks’ postpartum and 6-months postpartum. Prevalence/incidence study participants who screened above cut-off on one or more of the 4–6 week mood and anxiety questionnaires were also administered a diagnostic interview for mood disorders and AD at approximately 8–12 weeks postpartum.

Discussion
This research addresses a number of gaps in our understanding of mood, anxiety and stress among pregnant and postpartum women. Specifically, gaps in our knowledge regarding the prevalence and incidence of (a) AD and mood disorders, and (b) anxiety and stress among women experiencing a medically high-risk pregnancy, interest in stress management training in pregnancy, mental health treatment barriers and access and screening for anxiety among pregnant and postpartum women are addressed. The findings from this series of studies have the potential to improve screening, assessment and treatment of mood and anxiety problems suffered by pregnant and postpartum women.
Predicting the consumption speed of a premixed flame subjected to unsteady stretch rates
Authors: Sahafzadeh Meysam , Dworkin Seth , Kostiuk Larry W.
Published: July 2021

The stretched laminar flame model provides a convenient approach to embed realistic chemical kinetics when simulating turbulent premixed flames. When positive-only periodic strain rates are applied to a laminar flame there is a notable phase lag and diminished amplitude in heat release rate. Similar results have being observed with respect to the other component of stretch rate, namely the unsteady motion of a curved flame when the stretch rates are periodic about zero. Both cases showed that the heat release rate or consumption speed of these laminar-premixed flames vary significantly from the quasi-steady flamelet model. Deviation from quasi-steady behaviour increases as the unsteady flow time scale approaches the chemical time scale that is set by the stoichiometry. A challenge remains in how to use such results predictively for local and instantaneous consumption speed for small segments of turbulent flames where their unsteady stretch history is not periodic.
This paper uses a frequency response analysis as a characterization tool to simplify the complex non-linear behaviour of premixed methane air flames for equivalence ratios from 1.0 down to 0.7, and frequencies from quasi-steady up to 2000 Hz using flame transfer functions. Various linear and nonlinear models were used to identify appropriate flame transfer functions for low and higher frequency regimes, as well as extend the predictive capabilities of these models. Linear models were only able to accurately predict the flame behaviour below a threshold of when the fluid and chemistry time scales are the same order of magnitude. Other proposed transfer functions were tested against arbitrary multi-frequency stretch inputs and were shown to be effective over the full range of frequencies.
Flat-Cladding Fiber Bragg Grating Sensors for Large Strain Amplitude Fatigue Tests
Authors: Feng Aihen , Chen Daolun , Li Cheng , Gu Xijia
Published: July 2021

We have successfully developed a flat-cladding fiber Bragg grating sensor for large cyclic strain amplitude tests of up to ±8,000 με. The increased contact area between the flat-cladding fiber and substrate, together with the application of a new bonding process, has significantly increased the bonding strength. In the push-pull fatigue tests of an aluminum alloy, the plastic strain amplitudes measured by three optical fiber sensors differ only by 0.43% at a cyclic strain amplitude of ±7,000 με and 1.9% at a cyclic strain amplitude of ±8,000 με. We also applied the sensor on an extruded magnesium alloy for evaluating the peculiar asymmetric hysteresis loops. The results obtained were in good agreement with those measured from the extensometer, a further validation of the sensor.
Micro/Nano Scale Amorphization of Silicon by Femtosecond Laser Irradiation
Authors: Kiani Amirkianoosh , Venkatakrishnan Krishnan , Tan Bo
Published: July 2021

This research aimed to investigate the feasibility of using direct amorphization of silicon induced by femtosecond laser irradiation for maskless lithography. A thin layer of amorphous silicon of predetermined pattern was first generated by irradiation by a femtosecond laser of Mega Hertz pulse frequency. The following KOH etching revealed that the amorphous silicon layer acted as an etch stop. Line width less than 1/67 the focused spot size was demonstrated and hence the proposed maskless lithography process has the potential of producing submicron and nanoscale features by employing a laser beam of shorter wavelength and a high NA focusing lens. Scanning Electron Microscope (SEM), a Micro-Raman and Energy Dispersive X-ray (EDX) spectroscopy analyses were used to evaluate the quality of amorphous layer and the etching process.  
Mobile Laser Scanned Point-Clouds for Road Object Detection and Extraction: A Review
Authors: Ma Lingfei , Li Ying , Li Jonathan , Wang Cheng , Wang Ruisheng , Chapman Michael A.
Published: July 2021

The mobile laser scanning (MLS) technique has attracted considerable attention for providing high-density, high-accuracy, unstructured, three-dimensional (3D) geo-referenced point-cloud coverage of the road environment. Recently, there has been an increasing number of applications of MLS in the detection and extraction of urban objects. This paper presents a systematic review of existing MLS related literature. This paper consists of three parts. Part 1 presents a brief overview of the state-of-the-art commercial MLS systems. Part 2 provides a detailed analysis of on-road and off-road information inventory methods, including the detection and extraction of on-road objects (e.g., road surface, road markings, driving lines, and road crack) and off-road objects (e.g., pole-like objects and power lines). Part 3 presents a refined integrated analysis of challenges and future trends. Our review shows that MLS technology is well proven in urban object detection and extraction, since the improvement of hardware and software accelerate the efficiency and accuracy of data collection and processing. When compared to other review papers focusing on MLS applications, we review the state-of-the-art road object detection and extraction methods using MLS data and discuss their performance and applicability. The main contribution of this review demonstrates that the MLS systems are suitable for supporting road asset inventory, ITS-related applications, high-definition maps, and other highly accurate localization services.
Quantification system for the viral dynamics of a highly pathogenic simian/human immunodeficiency virus based on an in vitro experiment and a mathematical model
Authors: Iwami Shingo , Holder Benjamin P , Beauchemin Catherine A. A. , Morita Satoru , Tada Tetsuko , Sato Kei , Igarashi Tatsuhiko , Miura Tomoyuki
Published: July 2021

Background
Developing a quantitative understanding of viral kinetics is useful for determining the pathogenesis and transmissibility of the virus, predicting the course of disease, and evaluating the effects of antiviral therapy. The availability of data in clinical, animal, and cell culture studies, however, has been quite limited. Many studies of virus infection kinetics have been based solely on measures of total or infectious virus count. Here, we introduce a new mathematical model which tracks both infectious and total viral load, as well as the fraction of infected and uninfected cells within a cell culture, and apply it to analyze time-course data of an SHIV infection in vitro.

Results
We infected HSC-F cells with SHIV-KS661 and measured the concentration of Nef-negative (target) and Nef-positive (infected) HSC-F cells, the total viral load, and the infectious viral load daily for nine days. The experiments were repeated at four different MOIs, and the model was fitted to the full dataset simultaneously. Our analysis allowed us to extract an infected cell half-life of 14.1 h, a half-life of SHIV-KS661 infectiousness of 17.9 h, a virus burst size of 22.1 thousand RNA copies or 0.19 TCID50, and a basic reproductive number of 62.8. Furthermore, we calculated that SHIV-KS661 virus-infected cells produce at least 1 infectious virion for every 350 virions produced.

Conclusions
Our method, combining in vitro experiments and a mathematical model, provides detailed quantitative insights into the kinetics of the SHIV infection which could be used to significantly improve the understanding of SHIV and HIV-1 pathogenesis. The method could also be applied to other viral infections and used to improve the in vitro determination of the effect and efficacy of antiviral compounds.
Cumulative Risk, Cumulative Outcome: A 20-Year Longitudinal Study
Authors: Atkinson Leslie , Beitchman Joseph , Gonzalez Andrea , Young Arlene , Wilson Beth , Escobar Michael , Chisholm Vivienne , Brownlie Elizabeth , Khoury Jennifer E. , Ludmer Jaclyn , Villani Vanessa
Published: July 2021

Cumulative risk (CR) models provide some of the most robust findings in the developmental literature, predicting numerous and varied outcomes. Typically, however, these outcomes are predicted one at a time, across different samples, using concurrent designs, longitudinal designs of short duration, or retrospective designs. We predicted that a single CR index, applied within a single sample, would prospectively predict diverse outcomes, i.e., depression, intelligence, school dropout, arrest, smoking, and physical disease from childhood to adulthood. Further, we predicted that number of risk factors would predict number of adverse outcomes (cumulative outcome; CO). We also predicted that early CR (assessed at age 5/6) explains variance in CO above and beyond that explained by subsequent risk (assessed at ages 12/13 and 19/20). The sample consisted of 284 individuals, 48% of whom were diagnosed with a speech/language disorder. Cumulative risk, assessed at 5/6-, 12/13-, and 19/20-years-old, predicted aforementioned outcomes at age 25/26 in every instance. Furthermore, number of risk factors was positively associated with number of negative outcomes. Finally, early risk accounted for variance beyond that explained by later risk in the prediction of CO. We discuss these findings in terms of five criteria posed by these data, positing a “mediated net of adversity” model, suggesting that CR may increase some central integrative factor, simultaneously augmenting risk across cognitive, quality of life, psychiatric and physical health outcomes.
On the Free Vibration Modeling of Spindle Systems: A Calibrated Dynamic Stiffness Matrix
Authors: Gaber Omar , Hashemi Seyed Mohammad
Published: July 2021

The effect of bearings on the vibrational behavior of machine tool spindles is investigated. This is done through the development of a calibrated dynamic stiffness matrix (CDSM) method, where the bearings flexibility is represented by mass less linear spring elements with tuneable stiffness. A dedicated MAT LAB code is written to develop and to assemble the element stiffness matrices for the system’s multiple components and to apply the boundary conditions.The developed method is applied to an illustrative example of spindle system.When the spindle bearings are modeled as simply supported boundary conditions, the DSM model results in a fundamental frequency much higher than the system’s nominal value.The simply supported boundary conditions are then replaced by linear spring elements, and the spring constants are adjusted such that the resulting calibrated CDSM model leads to the nominal
fundamental frequency of the spindle system.The spindle frequency results are also validated against the experimental data.The proposed method can be effectively applied to predict the vibration characteristics of spindle systems supported by bearings.
Acoustic Intervention in a Cultural Heritage: The Chapel of the Royal Palace in Caserta, Italy
Authors: Berardi Umberto , Iannace Gino , Ianniello Carmine
Published: July 2021

The modern use of ancient heritage sites can be, to say the least, challenging from an acoustical perspective. In fact, modern needs may require acoustical interventions in contrast with the preservation issues of the cultural heritage. This paper deals with this topic in an UNESCO designated world heritage site, the Palatine Chapel of the Royal Palace in Caserta, Italy. Since this chapel is currently being used for meetings and music chamber concerts, the acoustical characteristics of the chapel, originally used for religious purposes, are investigated. Field measurements were undertaken to evaluate the acoustical performance of the empty chapel. The measurements were then used to calibrate and validate a computer simulation model. Different acoustical treatments are then considered and simulations are used to determine the related acoustical improvements. Finally, the benefits of different acoustical treatments which are respectful of the aesthetic and historical value of this cultural heritage are discussed.
Online Map Design for Public Health Decision-Makers
Authors: Cinnamon Jonathan , Rinner Claus , Cusimano Michael D. , Marshall Sean , Bekele Tsegaye , Hernandez Tony , Glazier Richard H. , Chipman Mary L.
Published: July 2021

Injury places a heavy burden on public-health resources that is not distributed evenly in space, making the mapping of injury and its socio-demographic risk factors an effective tool for prevention planning. In a survey of health-related interactive Web mapping applications we found great variation with respect to content, cartography, and technical aspects. Based on teh survey results, input from a group of potential end users, cartographic design principles, and data-set requirements, we created a Web site with static, animated, and interactive injury maps. We mapped injury rates and possible socio-deomgraphic risk factors for the City of Toronto. Through the three functionally different types of maps, a variety of ways to explore the same public-health data sets could be demostrated. The results highlight the practical options available to public-health analysts and decision makers who wish to expand their data-exploration and decision-support tools with a spatial component.
Freeze-dried plasma proteins are stable at room temperature for at least 1 year
Authors: Dufresne Jaimie , Hoang Trung , Ajambo Juliet , Florentinus-Mefailoski Angelique , Bowden Peter , Marshall John
Published: July 2021

Thirty human EDTA plasma samples from male and female subjects ranging in age from 24 to 74 years were collected on ice, processed ice cold and stored frozen at −80 °C, in liquid nitrogen (LN2), or freeze dried and stored at room temperature in a desiccator (FDRT) or freeze dried and stored at −20 °C for 1 year (FD-20). In a separate experiment, EDTA plasma samples were collected onto ice, processed ice cold and maintained on ice ± protease inhibitors versus incubated at room temperature for up to 96 h. Random and independent sampling by liquid chromatography and tandem mass spectrometry (LC–ESI–MS/MS), as correlated by the MASCOT, OMSSA, X!TANDEM and SEQUEST algorithms, showed that tryptic peptides from complement component 4B (C4B) were rapidly released in plasma at room temperature. Random sampling by LC–ESI–MS/MS showed that peptides from C4B were undetectable on ice, but peptides were cleaved from the mature C4B protein including NGFKSHALQLNNR within as little as 1 h at room temperature. The frequency and intensity of precursors within ± 3 m/z of the C4B peptide NGFKSHALQLNNR was confirmed by automated targeted analysis where the precursors from MS/MS spectra that correlated to the target sequence were analyzed in SQL/R. The C4B preproprotein was processed at the N terminus to release the mature chain that was cleaved on the carboxyl side of the isoprene C2 domain within a polar C terminal sequence of the mature C4B protein, to reveal the thioester reaction site, consistent with LC–ESI–MS/MS and Western blot. Random sampling showed that proteolytic peptides from complement component C4B were rarely observed with long term storage at − 80 °C in a freezer or in liquid nitrogen (LN2), freeze drying with storage at − 20 °C (FD-20 °C) or freeze drying and storage at room temperature (FDRT). Plasma samples maintained at room temperature (RT) showed at least 10-fold to 100-fold greater frequency of peptide correlation to C4B and measured peptide intensity compared to samples on ice for up to 72 h or stored at − 80 °C, LN2, FDRT or FD-20 °C for up to a year.