bluuebunny/crossref_metadata_2025 huggingface dataset:
The regulating effect of growth plasticity on the dynamics of structured populations
Authors: Croll Jasper C. , de Roos Andé M.
Published: March 2022

Plasticity is the extent to which life history processes such as growth and reproduction depend on the environment. Plasticity in individual growth varies widely between taxa. Nonetheless, little is known about the effect of plasticity in individual growth on the ecological dynamics of populations. In this article, we analyse a physiologically structured population model of a consumer population in which the individual growth rate can be varied between entirely plastic to entirely non-plastic. We derive this population level model from a dynamic energy budget model to ensure an accurate energetic coupling between ingestion, somatic maintenance, growth and reproduction within an individual. We show that the consumer population is either limited by adult fecundity or juvenile survival up to maturation, depending on the level of growth plasticity and the non-plastic individual growth rate. Under these two regimes, we also find two different types of population cycles which again arise due to fluctuation in, respectively, juvenile growth rate or adult fecundity. In the end, our model not only provides insight into the effects of growth plasticity on population dynamics, but also provides a link between the dynamics found in age- and size-structured models.
The gulf of cross-disciplinary research collaborations on global river basins is not narrowed
Authors: Wei Yongping , Wu Shuanglei
Published: March 2022

Using publications in the Web of Science database (WoS), this study investigates the research collaboration on the top 95 most researched global river basins since 1900. The links of both the disciplines involved and the management issues studied between the biophysical, economic, societal, climatic and governance sub-systems of these river basins were examined. We found that research collaborations were dominated within the biophysical sub-system (65.3%) since the knowledge predevelopment period (1900–1983), with continuous increases (by 18.5%) during the rapid development (1984–2000) and the stabilisation (12.9% increase) (2001–2017). However, research collaborations related to the societal sub-system remained marginalised (varied at about 1%), while those related to the governance sub-system expanded in issues studied (32.8%) but were not supported by the core governance disciplines (3.4%). The key findings explained why global river basins are degraded from the perspective of knowledge development and they can assist the strategic planning and management of scientific research for improving governance capacity in modifying the relationship between human and nature on river basins in the Anthropocene. Tackling challenges in the Anthropocene requires transformation of the current pattern of knowledge development, a revolution in the governance of science.
A pilot project for the long-term structural health monitoring of historic city gates
Authors: Zini Giacomo , Betti Michele , Bartoli Gianni
Published: March 2022

This paper reports on a pilot project for long-term structural health monitoring of historical city gates. This structural typology is what today remains of the defensive structures that characterised the medieval centres of many European cities. Even though in the last years the scientific community has paid great attention to the structural analysis and on the structural health monitoring of masonry towers, which are apparently similar to the typology of city gates, only a few studies explicitly approach such heritage buildings. In most cases, the surviving gates are immersed in the daily vehicular-traffic flows and hence continuously subjected to traffic-induced vibration. Consequently, a key point both for their conservation is the assessment of the optimal sensors position to be used for reliable structural health monitoring procedures. These issues are here discussed with reference to a specific case: the San Niccolò gate in Florence (Italy). First, an expeditious experimental campaign performed with a reduced number of accelerometers is reported. This test is aimed to identify a numerical model that is subsequently employed to design the optimal sensor position of long-term structural monitoring. This optimal sensor grid must be assessed to ensure a low-cost and sustainable dynamic monitoring system but, at the same time, to maximize the information contents.
Valorization of landscape management grass
Authors: Krenz Lina Maja Marie , Pleissner Daniel
Published: March 2022

The aim of this review was to investigate and develop possible material and energetic utilization strategies for grass from nature conservation areas, which is harvested late in the year and currently largely unused. Compared to freshly harvested grass, it contains less proteins and higher contents of fibers. Landscape management grass has therefore poor forage quality and is not suitable as animal feed. Due to its high calorific value, grass biomass can be used as a material for combustion. However, combustion technology must be adapted to the high contents of inorganics. Fresh grass is a widely used feedstock in biogas plants; late-harvested grass however shows lower biogas yields. The integrated generation of solid fuel and biogas represents a promising combination of combustion and digestion. Grass biomass can also be used in a green biorefinery (GBR) or a lignocellulose biorefinery (LCB). A GBR uses fresh green biomass, producing a protein concentrate (recovery of 30–60%, w/w) and a fiber fraction (recovery of up to 95%, w/w). It is supposed that late-harvested grass is less suitable due to low contents of exploitable components. An LCB operates on dry lignocellulosic feedstock and produces a wide range of carbohydrate products. To date, no LCB or GBR operating on late-harvested grass from semi-natural grasslands was described, and further research on the practical implementation is needed.
Antinormality and m-isometry of shift on weighted trees
Authors: Khan Mohammad Irshad , Chandra Harish
Published: March 2022

The shift operator and its various generalizations are amongst the most widely studied operators on a Hilbert space. In this paper, we characterize antinormal and m-isometric shift operator S on the Hilbert space $$L^2({\mathcal {T}},\lambda ) $$

L
2

(
T
,
λ
)

associated with a locally finite directed weighted tree $${\mathcal {T}}$$
T
. We also discuss interesting connections between antinormality and m-isometry of S.
MRI Evaluation of the Lactating Breast
Authors: Chung Maggie , Ruiz-Cordero Roberto , Lee Amie Y. , Joe Bonnie N. , Kelil Tatiana
Published: March 2022

Purpose of Review

To review the MRI appearance of physiologic lactational changes, common benign pathologies, and malignancies in the lactating breast.

Recent Findings

The prevalence of pregnancy-associated breast cancer has increased as more women delay childbirth and lactation. There is a transient increase in breast cancer risk after delivery when women may be lactating. MRI is more sensitive than mammography and ultrasound for the evaluation of the extent of disease in lactating women.

Understanding the key MRI findings of benign and malignant pathologies in the lactating breast is critical for accurate diagnosis and prompt evaluation of pregnancy-associated breast cancer.
A Linguistic Group Best–Worst Method for Measuring Good Governance in the Third Sector: A Spanish Case Study
Authors: Licerán-Gutiérrez Ana , Ortega-Rodríguez Cristina , Moreno-Albarracín Antonio Luis , Labella Álvaro , Rodríguez Rosa M. , Martínez Luis
Published: March 2022

The need of Non-profit Organizations (NPOs) of generating trust and credibility, to their stakeholders by an efficient management of their resources, lead them to openly show that they develop adequate good governance practices. But this is not a simple task and few research has been done on measuring methods of good governance in this field; without achieving an agreement about the best procedure. This paper aims at facilitating the measurement of good governance practices in NPOs by a fuzzy linguistic consensus-based group multi-criteria decision-making (MCGDM) model that will provide agreed and easy-understanding weights for a list of indicators proposed by the stakeholders and entities in such good governance practices. To do that, a linguistic 2-tuple BWM method with a consensus reaching process (CRP) will be developed and then applied to a real-world case in Spain, in which a group of experts from significant Spanish NPOs will assess the list of indicators proposed by the most representative entities (the alliance between the non-governmental organizations (NGO) Platform for Social Action, and the NGO Coordinator for Development (CONGDE) to obtain a prioritization of such indicators for measuring the good governance practices in Spanish NPOs.
MSMT-CNN for Solar Active Region Detection with Multi-Spectral Analysis
Authors: Almahasneh Majedaldein , Paiement Adeline , Xie Xianghua , Aboudarham Jean
Published: March 2022

Precisely detecting solar active regions (AR) from multi-spectral images is a challenging task yet important in understanding solar activity and its influence on space weather. A main challenge comes from each modality capturing a different location of these 3D objects, as opposed to more traditional multi-spectral imaging scenarios where all image bands observe the same scene. We present a multi-task deep learning framework that exploits the dependencies between image bands to produce 3D AR detection where different image bands (and physical locations) each have their own set of results. Different feature fusion strategies are investigated in this work, where information from different image modalities is aggregated at different semantic levels throughout the network. This allows the network to benefit from the joint analysis while preserving the band-specific information. We compare our detection method against baseline approaches for solar image analysis (multi-channel coronal hole detection, SPOCA for ARs (Verbeeck et al. Astron Astrophys 561:16, 2013)) and a state-of-the-art deep learning method (Faster RCNN) and show enhanced performances in detecting ARs jointly from multiple bands. We also evaluate our proposed approach on synthetic data of similar spatial configurations obtained from annotated multi-modal magnetic resonance images.
Spinal mobility and muscle function in middle-aged patients treated for early onset idiopathic scoliosis: compared with untreated and treated adolescent onset patients
Authors: Romberg Karin , Danielsson Aina , Olsén Monika Fagevik , Kjellby-Wendt Gunilla
Published: March 2022

Purpose

To determine long-term outcome in terms of spinal range of motion (ROM) and trunk muscle endurance (TME) patients treated for idiopathic scoliosis, diagnosed before the age of ten, were evaluated and compared with untreated or treated patients with idiopathic scoliosis with adolescent onset (AIS).

Methods

Sixty-three braced and 53 operated patients underwent examination of spinal ROM and TME. Validated questionnaires were used for evaluation of back function.

Results

A total of 116 patients were examined 26.5 years after treatment. Braced EOS patients had longer bracing time and operated EOS patients had longer fusions compared to the respective AIS groups. Braced EOS patients had similar total ROM (thoracic ROM 40°, lumbar ROM 78°) and TME (trunk flexors 140 s, trunk extensors 255 s) as untreated AIS patients (thoracic ROM 34°, lumbar ROM 88°, trunk flexor endurance 158 s, trunk extensor endurance 234 s). Braced patients also had significantly better results than braced AIS patients. Operated EOS patients were slightly but significantly stronger and more mobile compared to AIS peers. The lumbar ROM was found to affect the back function in the operated EOS group (Oswestry Questionnaire, rs = 0.49,p < 0.001).

Conclusions

The braced EOS patients had mostly similar muscle strength and mobility as the untreated but younger AIS group, while the braced AIS group showed reductions of both strength and mobility. Similar significant, but small, differences were also found between operated EOS and AIS patients. Especially for muscle strength were findings at a level that would be of significant clinical importance.

Levels of evidence

III.
The Hong Kong-China Nexus
Authors: Carroll John M
Published: March 2022

The Occupy Central/Umbrella Movement of 2014 and the anti-extradition protests of 2019 revealed how much Hong Kong's relationship with mainland China has deteriorated since the former British colony returned to Chinese sovereignty in July 1997. With mutual distrust and suspicion at an all-time high, many Hong Kong people have become increasingly hostile toward the Chinese government and the mainland in general, identifying themselves as Hongkongers rather than as Chinese. Yet, as John Carroll shows, for more than 150 years, colonial Hong Kong and China not only coexisted with but benefited each other, even during the anti-imperialist campaigns of the Republican and Communist eras. The porous boundary between Hong Kong and China enabled the two to use each other economically, politically, socially, and culturally. The Hong Kong–China nexus, although firmly embedded in global dynamics of colonialism, Cold War politics, and capitalist expansion, defies many common assumptions about nationalism, colonialism, and decolonization.
The Kingdom of Darkness
Authors: Levitin Dmitri
Published: March 2022

In 1500, speculative philosophy lay at the heart of European intellectual life; by 1700, its role was drastically diminished. The Kingdom of Darkness tells the story of this momentous transformation. Dmitri Levitin explores the structural factors behind this change: the emancipation of natural philosophy from metaphysics; theologians' growing preference for philology over philosophy; and a new conception of the limits of the human mind derived from historical and oriental scholarship, not least concerning China and Japan. In turn, he shows that the ideas of two of Europe's most famous thinkers, Pierre Bayle and Isaac Newton, were both the products of this transformation and catalysts for its success. Drawing on hundreds of sources in many languages, Levitin traces in unprecedented detail Bayle and Newton's conceptions of what Thomas Hobbes called The Kingdom of Darkness: a genealogical vision of how philosophy had corrupted the human mind. Both men sought to remedy this corruption, and their ideas helped lay the foundation for the system of knowledge that emerged in the eighteenth century.
SINR percolation for Cox point processes with random powers
Authors: Jahnel Benedikt , Tóbiás András
Published: March 2022

Signal-to-interference-plus-noise ratio (SINR) percolation is an infinite-range dependent variant of continuum percolation modeling connections in a telecommunication network. Unlike in earlier works, in the present paper the transmitted signal powers of the devices of the network are assumed random, independent and identically distributed, and possibly unbounded. Additionally, we assume that the devices form a stationary Cox point process, i.e., a Poisson point process with stationary random intensity measure, in two or more dimensions. We present the following main results. First, under suitable moment conditions on the signal powers and the intensity measure, there is percolation in the SINR graph given that the device density is high and interferences are sufficiently reduced, but not vanishing. Second, if the interference cancellation factor
$\gamma$
and the SINR threshold
$\tau$
satisfy
$\gamma \geq 1/(2\tau)$
, then there is no percolation for any intensity parameter. Third, in the case of a Poisson point process with constant powers, for any intensity parameter that is supercritical for the underlying Gilbert graph, the SINR graph also percolates with some small but positive interference cancellation factor.
Seroprevalence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) among healthcare providers prior to the vaccine era in an integrated midwestern healthcare system
Authors: Saade Elie A. , Zhang Xiaochun , Noguez Jaime H , Stempak Lisa M. , Tisch Daniel , Schmotzer Christine , Salata Robert A.
Published: March 2022

We performed severe acute respiratory coronavirus virus 2 (SARS-CoV-2) antinucleocapsid IgG testing on 5,557 healthcare providers and found a seroprevalence of 3.9%. African Americans were more likely to test positive than Whites, and HCWs with household exposure and those working on COVID-19 cohorting units were more likely to test positive than their peers.
The IRB Reliance Exchange (IREx): A national web-based platform for operationalizing single IRB review
Authors: Serdoz Emily Sheffer , Edwards Terri , Pulley Jill , Beadles Jenni , Ozier Julie , Harris Paul , Bernard Gordon R. , Rice Todd W.
Published: March 2022

For decades, the research community called for streamlined Institutional Review Board (IRB) review processes for multisite studies. Department of Health and Human Services and National Institutes of Health (NIH) recognized this need and implemented single IRB (sIRB) of record mandates. However, announcing mandates without sufficient operational guidance and tools is insufficient to foster the desired change. Nearly 4 years into implementation of the NIH’s sIRB mandate, operational challenges remain. Fortunately, NIH supports a web-based sIRB platform, the IRB Reliance Exchange (IREx), to facilitate sIRB communication and documentation. IREx has received continuous NIH funding supporting its evolution since 2011 and is now used by over 5,000 Human Research Protection Program and research personnel, 35 sIRBs, and 415 participating sites to operationalize sIRB review and approval on over 400 studies. IREx supports over 2300 reliance relationships with an average of 7 sites per study. The platform is continually used by sIRBs and relying sites, providing a valuable centralized portal for promoting a harmonized sIRB review process. IREx can promote transparency, standardize practice, minimize workflow variation, and mitigate the need for sIRBs to implement significant technical changes to their local electronic systems. IREx has proven to be nimble and adaptable with practice and policy changes over the past decade, as evidenced by continually increasing platform utilization.
Mutual Impacts of the COVID-19 Pandemic and the Recent Earthquakes: A Scoping Review of the Lessons Learned
Authors: Sayfouri Nasrin , Heidari Mohammad , Miresmaeeli Seyedeh Samaneh
Published: March 2022

Objective:

The aim of this study was to review the articles dealing with the mutual impacts of the coronavirus disease 2019 (COVID-19) pandemic and the recent earthquakes to elicit the various scopes of the lessons learned including the challenges, the successful measures, and the recommendations.

Methods:

To detect the relevant studies published between February 1, 2020, and June 9, 2021, PubMed, Web of Science, Scopus, and Google Scholar were searched. Having considered specific inclusion/exclusion criteria, 18 studies were included.

Results:

Seven major earthquakes have occurred concurrently or before the pandemic era in Albania, Croatia, Haiti, Great East Japan, Mexico, Nepal, and Utah. Thematic analysis revealed 5 themes for the “challenges” (management inefficiency, increased life-threatening, economic, socially related, and dual psychological challenges); 4 themes for the “efficient response measures” (health-care services measures, government measures, community-based cooperative activities, and disaster management response); and 3 major themes with 7 sub-themes for the “recommendations” including “the mitigation phase” (identifying probable natural disasters), “the preparedness phase” (preparing necessary equipment), and “the response phase” (mental care response measures, health-care-related COVID-19 measures, economic improvement measures, recognizing community-based capabilities, and government-related boosting measures).

Conclusions:

It is suggested that these scopes of the mutual impacts of the COVID-19 pandemic and the earthquakes be studied in systematic reviews.
Consequences of the German Constitutional Court’s Ruling on Germany’s Foreign Intelligence Service: The Importance of Human Rights in the Cooperation of Intelligence Services
Authors: Kappler Katrin
Published: March 2022

In 2020, Germany’s Federal Constitutional Court made a groundbreaking decision on foreign surveillance by the Federal Intelligence Service, the Bundesnachrichtendienst (BND). The Court’s first central finding was that the protection of fundamental rights is not limited to German territory. In addition, the ruling declared unconstitutional the regulations governing the transfer of information to foreign intelligence services. The ruling will therefore also have consequences for the cooperation of intelligence services, making it relevant abroad as well. In the ruling, the Court focused primarily on the role of human rights and ruled that the BND must check whether its cooperation partners respect human rights. The German parliament was given the task of implementing the Court’s demands. The law adopted in response to the Court’s demands came into force at the start of 2022. This article analyzes the ruling and the new law, and addresses the question what concrete requirements must be placed on the BND’s cooperation with foreign intelligence services.
Linking Money to Values: The New Rule of Law Conditionality Regulation and Its Constitutional Challenges
Authors: Baraggia Antonia , Bonelli Matteo
Published: March 2022

In December 2020, the EU institutions finally approved the new Rule of Law Conditionality Regulation after a controversial legislative process. The new Regulation allows the Commission and the Council to suspend EU funds in case of breaches to the rule of law that have negative effects on the EU budget and financial interests. This article analyses the new Regulation against the background of the rise of conditionality as a tool of EU governance. It argues, in contrast to some of the first analyses of the new Regulation, that the amendments adopted during the legislative process cannot simply be seen as a watered-down compromise, but were crucial to ensure the legality of the new instrument. At the same time, the EU’s growing reliance on conditionality continues to raise profound constitutional questions that still needs to be adequately addressed in the institutional and academic debate.
Political Understanding
Authors: Lepoutre Maxime
Published: March 2022

Public opinion research has shown that voters accept many falsehoods about politics. This observation is widely considered troubling for democracy – and especially participatory ideals of democracy. I argue that this influential narrative is nevertheless flawed because it misunderstands the nature of political understanding. Drawing on philosophical examinations of scientific modelling, I demonstrate that accepting falsehoods within one's model of political reality is compatible with – and indeed can positively enhance – one's understanding of that reality. Thus, the observation that voters accept many political falsehoods does not necessarily establish that they lack political understanding. I then address three worries: that voters cannot generally engage in such political modelling; that political modelling obscures facts that are crucial to political understanding; and that successful political modelling would require knowing that one's model contains falsehoods. My responses reveal how, going forward, we should measure political ignorance, and they highlight the standing importance of participatory democracy.
A narrowly endemic species of Begoniaceae: rediscovery, distribution and conservation ofBegonia jocelinoi
Authors: Paglia Isis , Luber Jaquelini , Mansano Vidal de Freitas , Freitas Leandro
Published: March 2022

Begonia jocelinoiBrade (Begoniaceae) is a threatened species, endemic to a small locality in the Brazilian Atlantic Forest. The species was formerly listed as Wanted in the Red List of Endemic Flora of the state of Rio de Janeiro because it had not been recorded since 1953. After evaluating herbarium collections and conducting fieldwork during May 2019–February 2020, we report the rediscovery of a single population of 65 reproductive individuals ofB. jocelinoi, along with numerous seedlings, besides a trail in Itatiaia National Park. This Park is an IUCN category II protected area that permits some tourism activities. Some individuals ofB. jocelinoishowed signs of pruning following the maintenance of the trail. We recommend strategies for in situ and ex situ conservation of this narrowly endemic species, including provision of advice to tourists regarding the occurrence of threatened species, and diversion of the trail where the species occurs.
The Contested Right of Public Meeting in England from the Bill of Rights to the Public Order Acts
Authors: Navickas Katrina
Published: March 2022

The ‘right of public meeting’ has historically been a key demand of extra-parliamentary political movements in England. This paper examines how public assembly came to be perceived as a legally protected right, and how national and local authorities debated and policed political meetings. Whereas previous histories have suggested that a ‘liberal governance’ dominated urban government during the nineteenth century, this paper offers an alternative framework for understanding the relationship between people and the state. It points to rights paradoxes, whereby the right of free passage and to ‘air and recreation’ often conflicted with the demand for the right of political meeting in challenges to use of public spaces. Local authorities sought to defend the rights of property against political movements by using the common law offences of obstruction and ‘nuisance’. By the first half of the twentieth century, new threats of militant tactics and racial harassment by political groups necessitated specific public order legislation. Though twentieth-century legislation sought to protect certain types of assembly and protest marches, the implementation and policing of public order was spatially discriminatory, and the right of public meeting was left unresolved.
A call for comparing theories of consciousness and data sharing
Authors: Eagleman Sarah L. , Eagleman David M. , Menon Vinod , Meador Kimford J.
Published: March 2022

Merker, Williford, and Rudrauf make several arguments against the integrated information theory of consciousness; whereas some have merit, their conclusion that the theory should be discarded is premature. Coming years promise advances in the empirical study of consciousness, and only after theories are independently tested with shared data can they be ruled in or out. We propose future research directions.
IIT is ideally positioned to explain perceptual phenomena
Authors: Haun Andrew M.
Published: March 2022

The target article's critique of the integrated information theory (IIT) of consciousness is misguided on several fronts, which I hope are addressed in other comments, but here I focus on the connection (or supposed lack thereof) between IIT and rigorous phenomenology, and IIT's connection to the psychophysics of perception.
To be or to know? Information in the pristine present
Authors: Albantakis Larissa
Published: March 2022

To be true of every experience, the axioms of Integrated information theory (IIT) are necessarily basic properties and should not be “over-psychologized.” Information, for example, merely asserts that experience is specific, not generic. It does not require “access.” The information a system specifies about itself in its current state is revealed by its unfolded cause–effect structure and quantified by its integrated information.
Anatomical, physiological, and psychophysical data show that the nature of conscious perception is incompatible with the integrated information theory (IIT)
Authors: Gur Moshe
Published: March 2022

The integrated information theory (IIT) equates levels of consciousness with the amount of information integrated over the elements that constitute a system. Conscious visual perception provides two observations that contradict the IIT. First, objects are accurately perceived when presented for ≪100 ms during which time no neural integration is possible. Second, an object is seen as an integrated whole and, concurrently, all constituent elements are evident. Because integration destroys information about details, IIT cannot account for perceptual detail preservation.
IIT, half masked and half disfigured
Authors: Tononi Giulio , Boly Melanie , Grasso Matteo , Hendren Jeremiah , Juel Bjorn E. , Mayner William G. P. , Marshall William , Koch Christof
Published: March 2022

The target article misrepresents the foundations of integrated information theory (IIT) and ignores many essential publications. It, thus, falls to this lead commentary to outline the axioms and postulates of IIT and correct major misconceptions. The commentary also explains why IIT starts from phenomenology and why it predicts that only select physical substrates can support consciousness. Finally, it highlights that IIT's account of experience – a cause–effect structure quantified by integrated information – has nothing to do with “information transfer.”
Microhabitats, macro-differences: a survey of temperature records in Victoria Land terrestrial and freshwater environments
Authors: Cucini Claudio , Nardi Francesco , Magnoni Letizia , Rebecchi Lorena , Guidetti Roberto , Convey Peter , Carapelli Antonio
Published: March 2022

The temperature experienced by micro-invertebrates in extreme environments (such as those of Antarctica) is a pivotal parameter regarding these animals' ecology and physiology. However, at present, detailed knowledge of microhabitat physical conditions in Antarctica is limited, as well as being biased towards sub-Antarctic and Maritime Antarctic regions. To better understand the temperature conditions experienced in the microhabitats of Continental Antarctica by the native microfauna, we recorded temperatures year round in ponds and soils in an area of the Victoria Land coast and compared these measurements with air temperature data from the closest automatic weather station. We identified an important difference in temperature dynamics between the air, soil and pond datasets. Ponds were the warmest sites overall, differing by up to 7.5°C in comparison with the air temperature due to their greater thermal capacity, which also drove their patterns of freeze-thaw cycles and mean daily thermal excursion.
Mapping the Distribution of Special Structured Pulmonary Vasculatures in the Dromedary Camel (Camelus dromedarius): Histological and Histochemical Study
Authors: Mohamedien Dalia , Mohamed Salma A. , Salem Ahmed O. , Fath El-Bab Mohamed R.
Published: March 2022

Dromedary camel (Camelus dromedarius) is adapted to survive the harsh environments. It has some key adaptation peculiarities in various organs. In this study, we aimed to map the distribution pattern of unique regulatory devices along the course of the pulmonary vessels using histological and histochemical analyses. Arteries with variable wall thickness and spirally oriented course were recorded within the adventitia of the main pulmonary artery. Throttle arteries and glomus bolsters were found within the wall of the lobar pulmonary artery. The bronchial artery was located within the wall of all bronchi reaching the subsegmental branches and it had elastic longitudinal muscular intima bolsters. Arteries with double muscular media were demonstrated in the pulmonary pleura. These bolsters are suggested to play a complicated role that allows for hemodynamic, humeral, and thermoregulatory activities. The lumen of some subsegmental pulmonary veins revealed occasional constrictions arising from the corresponding muscular pad-like protrusions of the tunica media. These veins may possess occlusive or constrictive mechanisms and their obstruction induces engorgement of the associated capillary bed in addition to restricting venous outflow. Collectively, these data strongly recommend a crucial role for the special regulatory devices in preserving the camel pulmonary function in the harsh desert environment.
Improved feeds for log-periodic microstrip antenna arrays
Authors: Muduli Arjuna , Mishra Rabindra K.
Published: March 2022

This note proposes a log-periodic microstrip antenna (LPMA), particularly after developing possible feed structures. The process develops an appropriate feed such that the LPMA can exhibit almost end-fire characteristics such as a log-periodic dipole antenna. The study simulated two LPMAs, one with five elements and the other with seven elements, followed by measurements on a five-element prototype. The five-element prototype LPMA with such a feed exhibits a bandwidth of 2.2–3 GHz. Over this band, radiation patterns remain consistent with a gain of 9.8 dBi. Simulated results follow the measured ones closely.
Where did the Arizona‐Plano Go? Protracted Thinning Via Upper‐ to Lower‐Crustal Processes
Authors: Jepson Gilby , Carrapa Barbara , George Sarah W. M. , Reeher Lauren J. , Kapp Paul A. , Davis George H. , Thomson Stuart N. , Amadori Chiara , Clinkscales Christopher , Jones Sean , Gleadow Andrew J. W. , Kohn Barry P.
Published: March 2022

Mesozoic‐Cenozoic subduction of the Farallon slab beneath North America generated a regionally extensive orogenic plateau in the southwestern US during the latest Cretaceous, similar to the modern Central Andean Plateau. In Nevada and southern Arizona, estimates from whole‐rock geochemistry suggest crustal thicknesses reached ∼60–55 km by the Late Cretaceous. Modern crustal thicknesses are ∼28 km, requiring significant Cenozoic crustal thinning. Here, we compare detailed low‐temperature thermochronology from the Catalina metamorphic core complex (MCC) to whole rock Sr/Y crustal thickness estimates across southern Arizona. We identify three periods of cooling. A minor cooling phase occurred prior to ∼40 Ma with limited evidence of denudation and ∼10 km of crustal thinning. Major cooling occurred during detachment faulting and MCC formation at 26–19 Ma, corresponding to ∼8 km of denudation and ∼8 km of crustal thinning. Finally, we document a cooling phase at 17–11 Ma related to Basin and Range extension that corresponds with ∼5 km of denudation and ∼9 km of crustal thinning. During the MCC and Basin and Range extension events, the amount of denudation recorded by low‐temperature thermochronology can be explained by corresponding decreases in the crustal thickness. However, the relatively limited exhumation prior to detachment faulting at ∼26 Ma recorded by thermochronology is insufficient to explain the magnitude of crustal thinning (∼10 km) observed in the whole rock crustal thickness record. Therefore, we suggest that crustal thinning of the Arizona‐plano was facilitated via ductile mid‐ to lower‐crustal ﬂow, and limited upper‐crustal extension at 50–30 Ma prior to detachment faulting and Basin and Range extension.
Simulation of Geomagnetically Induced Currents in a Low‐Latitude 500 kV Power Network During a Solar Superstorm
Authors: Zhang J. J. , Yu Y. Q. , Chen W. Q. , Wang C. , Liu Y. D. , Liu C. M. , Liu L. G.
Published: March 2022

Geomagnetically induced currents (GICs) are one of the main manifestations through which space weather affects human technical facilities, and GICs constitute the final link in the solar wind‐magnetosphere‐ionosphere‐ground interaction chain. Therefore, understanding the responses of power grids to solar superstorms is crucial for space weather research and emergency preparedness purposes. In this work, we combine the Space Weather Modeling Framework with a ground conductivity model and a model of the Chinese Guangdong 500 kV power grid to investigate the response of the whole power grid if the 23 July 2012 solar superstorm had struck the Earth. The maximum |GICs| produced in the power grid by this event reach approximately 400 A, which is more than thrice those measured during a strong magnetic storm with Kp = 8. Based on statistical analyses of the strength and duration of large GICs at 54 substations and a comparison with the GICs responsible for the Hydro‐Québec power outage on 13 March 1989, we stipulate that the risk of GICs in the Guangdong 500 kV power grid is very high. The simulation results also reveal that field‐aligned currents can play an important role in producing GICs in middle‐ and low‐latitude power grids during solar superstorms. This finding provides crucial insight for understanding the factors that generate strong GICs at middle and low latitudes.
Satellites’ Lasers Reveal Changes in Earth’s Water Movement
Authors: Wendel JoAnna
Published: March 2022

The laser-based instruments aboard the GRACE-FO satellites may be extended to other geophysical applications to collect data on other submonthly mass changes in Earth’s system.
Comparison of ultrashort pulse ablation of gold in air and water by time-resolved experiments
Authors: Spellauge Maximilian , Doñate-Buendía Carlos , Barcikowski Stephan , Gökce Bilal , Huber Heinz P.
Published: March 2022

Laser ablation in liquids is a highly interdisciplinary method at the intersection of physics and chemistry that offers the unique opportunity to generate surfactant-free and stable nanoparticles from virtually any material. Over the last decades, numerous experimental and computational studies aimed to reveal the transient processes governing laser ablation in liquids. Most experimental studies investigated the involved processes on timescales ranging from nanoseconds to microseconds. However, the ablation dynamics occurring on a sub-nanosecond timescale are of fundamental importance, as the conditions under which nanoparticles are generated are established within this timeframe. Furthermore, experimental investigations of the early timescales are required to test computational predictions. We visualize the complete spatiotemporal picosecond laser-induced ablation dynamics of gold immersed in air and water using ultrafast pump-probe microscopy. Transient reflectivity measurements reveal that the water confinement layer significantly influences the ablation dynamics on the entire investigated timescale from picoseconds to microseconds. The influence of the water confinement layer includes the electron injection and subsequent formation of a dense plasma on a picosecond timescale, the confinement of ablation products within hundreds of picoseconds, and the generation of a cavitation bubble on a nanosecond timescale. Moreover, we are able to locate the temporal appearance of secondary nanoparticles at about 600 ps after pulse impact. The results support computational predictions and provide valuable insight into the early-stage ablation dynamics governing laser ablation in liquids.
GNG2 acts as a tumor suppressor in breast cancer through stimulating MRAS signaling
Authors: Zhao Anjiang , Li Dan , Mao Xiongmin , Yang Mengliu , Deng Wuquan , Hu Wenjing , Chen Chen , Yang Gangyi , Li Ling
Published: March 2022

G-protein gamma subunit 2 (GNG2) is involved in several cell signaling pathways, and is essential for cell proliferation and angiogenesis. However, the role of GNG2 in tumorigenesis and development remains unclear. In this study, 1321 differentially expressed genes (DEGs) in breast cancer (BC) tissues were screened using the GEO and TCGA databases. KEGG enrichment analysis showed that most of the enriched genes were part of the PI3K-Akt signaling pathway. We identified GNG2 from the first five DEGs, its expression was markedly reduced in all BC subtype tissues. Cox regression analysis showed that GNG2 was independently associated with overall survival in patients with luminal A and triple-negative breast cancers (TNBC). GNG2 over-expression could significantly block the cell cycle, inhibit proliferation, and promote apoptosis in BC cells in vitro. In animal studies, GNG2 over-expression inhibited the growth of BC cells. Further, we found that GNG2 significantly inhibited the activity of ERK and Akt in an MRAS-dependent manner. Importantly, GNG2 and muscle RAS oncogene homolog (MRAS) were co-localized in the cell membrane, and the fluorescence resonance energy transfer (FRET) experiment revealed that they had direct interaction. In conclusion, the interaction between GNG2 and MRAS likely inhibits Akt and ERK activity, promoting apoptosis and suppressing proliferation in BC cells. Increasing GNG2 expression or disrupting the GNG2–MRAS interaction in vivo could therefore be a potential therapeutic strategy to treat BC.
Ferroptosis in oligodendrocyte progenitor cells mediates white matter injury after hemorrhagic stroke
Authors: Shen Danmin , Wu Weihua , Liu Jing , Lan Ting , Xiao Zhongnan , Gai Kaiyuan , Hu Liye , Luo Zhaoli , Wei Chao , Wang Xiaotong , Lu Yabin , Wang Yamei , Zhang Chenguang , Wang Peipei , Zuo Zhentao , Yang Fei , Li Qian
Published: March 2022

Oligodendrocyte progenitor cells (OPCs) differentiate to myelin-producing mature oligodendrocytes and enwrap growing or demyelinated axons during development and post central nervous diseases. Failure of remyelination owing to cell death or undifferentiation of OPCs contributes to severe neurologic deficits and motor dysfunction. However, how to prevent the cell death of OPCs is still poorly understood, especially in hemorrhagic diseases. In the current study, we injected autologous blood into the mouse lateral ventricular to study the hemorrhage-induced OPC cell death in vivo. The integrity of the myelin sheath of the corpus callosum was disrupted post intraventricular hemorrhage (IVH) assessed by using magnetic resonance imaging, immunostaining, and transmission electron microscopy. Consistent with the severe demethylation, we observed massive cell death of oligodendrocyte lineages in the periventricular area. In addition, we found that ferroptosis is the major cell death form in Hemin-induced OPC death by using RNA-seq analysis, and the mechanism was glutathione peroxidase 4 activity reduction-resulted lipid peroxide accumulation. Furthermore, inhibition of ferroptosis rescued OPC cell death in vitro, and in vivo attenuated IVH-induced white matter injury and promoted recovery of neurological function. These data demonstrate that ferroptosis is an essential form of OPC cell death in hemorrhagic stroke, and rescuing ferroptotic OPCs could serve as a therapeutic target for stroke and related diseases.
Binary dopant segregation enables hematite-based heterostructures for highly efficient solar H2O2 synthesis
Authors: Zhang Zhujun , Tsuchimochi Takashi , Ina Toshiaki , Kumabe Yoshitaka , Muto Shunsuke , Ohara Koji , Yamada Hiroki , Ten-no Seiichiro L. , Tachikawa Takashi
Published: March 2022

Dopant segregation, frequently observed in ionic oxides, is useful for engineering materials and devices. However, due to the poor driving force for ion migration and/or the presence of substantial grain boundaries, dopants are mostly confined within a nanoscale region. Herein, we demonstrate that core–shell heterostructures are formed by oriented self-segregation using one-step thermal annealing of metal-doped hematite mesocrystals at relatively low temperatures in air. The sintering of highly ordered interfaces between the nanocrystal subunits inside the mesocrystal eliminates grain boundaries, leaving numerous oxygen vacancies in the bulk. This results in the efficient segregation of dopants (~90%) on the external surface, which forms their oxide overlayers. The optimized photoanode based on hematite mesocrystals with oxide overlayers containing Sn and Ti dopants realises high activity (~0.8 μmol min−1 cm−2) and selectivity (~90%) for photoelectrochemical H2O2 production, which provides a wide range of application for the proposed concept.
The Chengjiang Biota inhabited a deltaic environment
Authors: Saleh Farid , Qi Changshi , Buatois Luis A. , Mángano M. Gabriela , Paz Maximiliano , Vaucher Romain , Zheng Quanfeng , Hou Xian-Guang , Gabbott Sarah E. , Ma Xiaoya
Published: March 2022

The Chengjiang Biota is the earliest Phanerozoic soft-bodied fossil assemblage offering the most complete snapshot of Earth’s initial diversification, the Cambrian Explosion. Although palaeobiologic aspects of this biota are well understood, the precise sedimentary environment inhabited by this biota remains debated. Herein, we examine a non-weathered core from the Yu’anshan Formation including the interval preserving the Chengjiang Biota. Our data indicate that the succession was deposited as part of a delta influenced by storm floods (i.e., produced by upstream river floods resulting from ocean storms). Most Chengjiang animals lived in an oxygen and nutrient-rich delta front environment in which unstable salinity and high sedimentation rates were the main stressors. This unexpected finding allows for sophisticated ecological comparisons with other Burgess Shale-type deposits and emphasizes that the long-held view of Burgess Shale-type faunas as snapshots of stable distal shelf and slope communities needs to be revised based on recent sedimentologic advances.
PCBP2 maintains antiviral signaling homeostasis by regulating cGAS enzymatic activity via antagonizing its condensation
Authors: Gu Haiyan , Yang Jing , Zhang Jiayu , Song Ying , Zhang Yao , Xu Pengfei , Zhu Yuanxiang , Wang Liangliang , Zhang Pengfei , Li Lin , Chen Dahua , Sun Qinmiao
Published: March 2022

Cyclic GMP-AMP synthase (cGAS) plays a major role in detecting pathogenic DNA. It produces cyclic dinucleotide cGAMP, which subsequently binds to the adaptor protein STING and further triggers antiviral innate immune responses. However, the molecular mechanisms regulating cGAS enzyme activity remain largely unknown. Here, we characterize the cGAS-interacting protein Poly(rC)-binding protein 2 (PCBP2), which plays an important role in controlling cGAS enzyme activity, thereby mediating appropriate cGAS-STING signaling transduction. We find that PCBP2 overexpression reduces cGAS-STING antiviral signaling, whereas loss of PCBP2 significantly increases cGAS activity. Mechanistically, we show that PCBP2 negatively regulates anti-DNA viral signaling by specifically interacting with cGAS but not other components. Moreover, PCBP2 decreases cGAS enzyme activity by antagonizing cGAS condensation, thus ensuring the appropriate production of cGAMP and balancing cGAS-STING signal transduction. Collectively, our findings provide insight into how the cGAS-mediated antiviral signaling is regulated.
Assessment of global health risk of antibiotic resistance genes
Authors: Zhang Zhenyan , Zhang Qi , Wang Tingzhang , Xu Nuohan , Lu Tao , Hong Wenjie , Penuelas Josep , Gillings Michael , Wang Meixia , Gao Wenwen , Qian Haifeng
Published: March 2022

Antibiotic resistance genes (ARGs) have accelerated microbial threats to human health in the last decade. Many genes can confer resistance, but evaluating the relative health risks of ARGs is complex. Factors such as the abundance, propensity for lateral transmission and ability of ARGs to be expressed in pathogens are all important. Here, an analysis at the metagenomic level from various habitats (6 types of habitats, 4572 samples) detects 2561 ARGs that collectively conferred resistance to 24 classes of antibiotics. We quantitatively evaluate the health risk to humans, defined as the risk that ARGs will confound the clinical treatment for pathogens, of these 2561 ARGs by integrating human accessibility, mobility, pathogenicity and clinical availability. Our results demonstrate that 23.78% of the ARGs pose a health risk, especially those which confer multidrug resistance. We also calculate the antibiotic resistance risks of all samples in four main habitats, and with machine learning, successfully map the antibiotic resistance threats in global marine habitats with over 75% accuracy. Our novel method for quantitatively surveilling the health risk of ARGs will help to manage one of the most important threats to human and animal health.