bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of Lithuania and Estonia transport management specialists competitiveness possibility
Authors: Ledauskaité Kristina
Published: May 2020

Global economical, social and cultural processes raise new challenges for management of human resources. That's way business needs is not a formal teaching, not diplomats, degrees, names, but effective education, which may secure full-rate competitiveness in modem economy's days. Competitive ability of the companies is close bound with company's management's activity's effectiveness, to have new opinions of management. If transport companies really want to form competitive companies personal, their must consequently apply all opportunities to change managers' managements' attitudes. Nowadays the main attention must be concentrate on the qualitative personal preparation, because for developing economical market nowadays it is necessary new specialists, who could to understand free-market working, to understood theory of modem economy and practice of business, also be able to communicate and collaborate with inward and other countries partners. Reaching this purpose, high schools must appreciate market's demands and regularize them with studies programs'. In other way graduates of transport management will have big problems with lack of practice and personal skills, which prevent guarantee equal conditions of employ, comparing with specialists which have experience. Evaluating possibilities transport management specialists' competitive ability it is necessary to research demands of transport market and to compare if transport management graduates equally understand situation in transport sectors as it is in reality. In this case it is important to research what are competitive abilities of transport management specialists in transport sector after graduating. Recently, very important are ability to adjust to changeable demands of market and, how transport management specialists cant apply theoretical skills in real practical work. This article shows that, there are some differences between situation in Lithuania and in Estonia transport management students' preparation, but herewith the students' opinions about their preparation are quite the same, and they agree that it is necessary to educate competitive ability. So in this article was researched evaluation of Lithuania and Estonia transport management specialists competitive ability possibility.
Rural tourism
Authors: Tomic Slavica
Published: May 2020

Global changes in the tourist market are characterized by an increasing representation of tourist forms differentiating from those for which the system 3S is valid (sun, sea, sand). The contemporary trend of moving from the concept of mass tourism to the individual forms of tourism opens to rural tourism the position in the world market of the 21th century. Rural tourism has no characteristics of massiveness and it is compatible with the aspects of sustainable tourism.
Információs rendszerek a dél-alföldi élelmiszeripari társas vállalkozásokban
Authors: Hampel György , Nagy Elemérné
Published: May 2020

Enterprise managers need reliable and processed information to make good decisions. To process the huge amount of data, computer based information systems are required. The self-made or standard information systems can be classified in many different ways: by the level of integration, level and type of decision support etc. Although computerized information systems are considered to give competitive advantage, it is not always easy to prove the return of investment when introducing such systems. According to the research conducted at bigger food industry enterprises in Hungary's Southern Great Plain region, the use of integrated information systems are widespread. On the other hand, there are a lot of enterprises, where some tasks are accomplished with different small systems that have no connection with each other. The systems are capable of analysing the current situation but are rarely used for forecasting.
Web2 environment as a platform for making natural and cultural values accessible to potential and actual clients
Authors: Timčák Gejza M. , Schleusener Heinz , Jablonská Jana
Published: May 2020

Services like tourism have to use the possibilities of modern advertising. In particular, these include the World Wide Web (WWW). This platform brings its products and services directly to the customers. To place the information about a region and its tourist offer in optimal manner requires exact definition of elements in the Web based tourist information system (WETIS) and their presentation. We discuss the elements and their integration in other services, the data structures and types, maps and their interactivity. Furthermore, we present tourism related data of selected Slovakian villages and cities. Finally, we give a report regarding our demonstration web page and future development. The usual tourist information on the web usually relates to the most interesting historical or cultural sights in the region and is marketing oriented. In this way the full image of history and beauty of the characteristic towns and villages is usually missed. Our intention was - in cooperation with the Geotourism students of the Institute if Geotourism - to map also these features of Eastern Slovakia and of the NE Carpathians. As the web is to serve mainly the tourist community, the map connects to useful information on various facilities available at the given locality. The detailed photo-documentation makes it possible e.g. also to see each traditional house. This is interesting as the number of these houses is decreasing. They are replaced by modern buildings, which lack the regional and local flavour.
Magyarország konvergencia programja és a világgazdasági válság
Authors: Gősi János
Published: May 2020

The convergence program of Hungary and the world economic crisis. The international financial and real economy crisis reached Hungary in the autumn of 2008, too. The crisis made the completion of the 2009. yearly state budget difficult very much and the continuation of the convergence program according to its plan, because the balance of the state budget is decaying because of the economical recession.
A tájhasználat változása a Hódmezővásárhelyi kistérségben a földhasználat és a felszínborítás változásának tükrében
Authors: Kis Krisztián
Published: May 2020

The proportion of the land use categories reflects the quality and intensity of the landscape use. According to the data the land use of the micro-region mostly defined by arable land, grassland (meadow/pasture), forest and uncultivated land, which are amounted to 99% of the area of the micro-region during the examined period. In spite of the short examined period it can be concluded from the examination that considerable changes took place in the landscape use of the micro-region which can be derived from the land use and land cover changes. It can be assessed as favourably change that forest areas increased but the increase of uncultivated land at the same time can be less favourable assessed. The proportion of forest and semi-natural areas, wetlands and water bodies also increased as the positive result of the land use change.
Mezőgazdasági termelékenységi vizsgálatok
Authors: Balogh Sándor
Published: May 2020

Our study examines the territorial productivity of agriculture and the productivity of agricultural work. The methodology of the research did not raise particular questions, whereas the collection and selection of data serving as the basis for the calculation did. After careful consideration, the Eurostat data were taken as the basis, with regard to the requirements of international comparison, too. As a result of the research it was found that the productivity of Hungarian agriculture is low concerning both indices. The figures show that it is found in the group of Member States which joined in 2004 and in 2007 in spite of the well-known fact that until 1990 Hungary was much ahead of those.
Pénzügyi lokalitás
Authors: Szabó Richárd
Published: May 2020

The subprime crises rooted by the globalised financial structure. The worldwide popular stock exhchange investment forms, the financial innovations and the support IT technolgies „help" to rise and collaps the financial markets. If we originated the quick expansion of the crises in the globalised system, then the outcome from the situation, the solution can be based by the localised financial opportunities. In this paper first I try to introduce the local forms of financial institutions. Historycall, its originated from the credit union (CU) , the save and loan association (S&L A) and the shareholders company form. Most local is the CU and the S&L A. Second I try to introduce the „financial localisation ratio" (FLR). This FLR derivated by international (US, UK and German) examples this ratio will be calculated in Hungary. Conclusion: the hungarian financial market and institution system is not enough developed to turn local.
Utazási szokások vizsgálata Hódmezővásárhelyen
Authors: Gál József , Kelemen László , Szeri István
Published: May 2020

Tisza Volán Zrt. made passenger counting and questionnaire poll collaborating with Szegedi Tudományegyetem, concerned with the service in order to obtain information on the travel habits of Hódmezővásárhely population related passenger from satisfaction. The result of the survey has an effect on the framing of the city's public transport. It passed since it under years actual results emerged.
A tanyai lakosság szerepe és helye a vidéki élet vérkeringésében
Authors: Gálné Horváth Ildikó
Published: May 2020

The Great Hungarian Plain one of the - nowadays mentioned as a 'Hungaricum' in the literature - form of settlement; the population living on the farms occupies specific place in the Hungarian society. Before years - centuries - of collectivization of the agriculture inhabitants working in agriculture, earning money from it was understand in the literature. Nowadays all this an occupational construction, all of them all changed a lot in the look of commerce. The peasantry had its share of a determining role in the Hungarian society's establishment in the course of the centuries; let it be an economy, sociology, a tradition, etc. In the past twenty years did not let the farms untouched. New inhabitants, who reveal a quite heterogeneous picture to us considering their occupation, their conduct, their social role, appeared on the farms.
Asymmetry between galaxies with different spin patterns: A comparison between COSMOS, SDSS, and Pan-STARRS
Authors: Shamir Lior
Published: May 2020

Previous observations of a large number of galaxies show differences between the photometry of spiral galaxies with clockwise spin patterns and spiral galaxies with counterclockwise spin patterns. In this study the mean magnitude of a large number of clockwise galaxies is compared to the mean magnitude of a large number of counterclockwise galaxies. The observed difference between clockwise and counterclockwise spiral galaxies imaged by the space-based COSMOS survey is compared to the differences between clockwise and counterclockwise galaxies imaged by the Earth-based SDSS and Pan-STARRS around the same field. The annotation of clockwise and counterclockwise galaxies is a fully automatic process that does not involve human intervention, and in all experiments both clockwise and counterclockwise galaxies are separated from the same fields. The comparison shows that the same asymmetry was identified by all three telescopes, providing strong evidence that the rotation direction of a spiral galaxy is linked to its luminosity as measured from Earth. Analysis of the luminosity difference using a large number of galaxies from different parts of the sky shows that the difference between clockwise and counterclockwise galaxies changes with the direction of observation, and oriented around an axis.
Two mixed-ligand coordination polymers based on 2,5-thiophenedicarboxylic
acid and flexible N-donor ligands: the protective effect on periodontitis via
reducing the release of IL-1β and TNF-α
Authors: Wu Shao-Hsuan , Huang Jun-Hui
Published: May 2020

Two novel mixed-ligand coordination polymers, {[Co(tdc)(btrp)]·0.67DMF}
n
(1) and
{[Zn2(bimb)2(tdc)2]·2H2O}
n
(2) involving 2,5-thiophenedicarboxylate (H2tdc), and bitopic
flexible N-donor ligands, 1,3-bis(1,2,4-triazol-1-yl)propane (btrp) and
1,4-bis((1H-benzo[d]imidazol-1-yl)methyl)benzene
(bimb), have been synthesized by the hydrothermal method and characterized via IR,
elemental analysis, thermal analysis, and powder X-ray diffraction. The biological
functional studies were performed; the treatment activity of the compounds on
periodontitis and the specific mechanism was explored. First, the real-time RT-PCR
was carried out to determine the inflammatory genes nf-κb and
p53 relative expression in periodontal mucosal cells after
treating with compounds 1 and 2. Then, the level of the
inflammatory cytokine in the gingival crevicular fluid after treating with compounds
was also determined by the ELISA detection kit.
On some extension of Paley Wiener theorem
Authors: N’Da Ettien Yves-Fernand , Kangni Kinvi
Published: May 2020

Paley Wiener theorem characterizes the class of functions which are Fourier transforms of ℂ∞ functions of compact support on ℝ
n
by relating decay properties of those functions or distributions at infinity with analyticity of their Fourier transform. The theorem is already proved in classical case : the real case with holomorphic Fourier transform on L
2(ℝ), the case of functions with compact support on ℝ
n
from Hörmander and the spherical transform on semi simple Lie groups with Gangolli theorem.

Let G be a locally compact unimodular group, K a compact subgroup of G, and δ an element of unitary dual ̑K of K. In this work, we’ll give an extension of Paley-Wiener theorem with respect to δ, a class of unitary irreducible representation of K, where G is either a semi-simple Lie group or a reductive Lie group with nonempty discrete series after introducing a notion of δ-orbital integral. If δ is trivial and one dimensional, we obtain the classical Paley-Wiener theorem.
From ℋ∞ to 𝒩. Pointwise properties and algebraic structure in the Nevanlinna class
Authors: Massaneda Xavier , Thomas Pascal J.
Published: May 2020

This survey shows how, for the Nevanlinna class 𝒩 of the unit disc, one can define and often characterize the analogues of well-known objects and properties related to the algebra of bounded analytic functions ℋ∞: interpolating sequences, Corona theorem, sets of determination, stable rank, as well as the more recent notions of Weak Embedding Property and threshold of invertibility for quotient algebras. The general rule we observe is that a given result for ℋ∞ can be transposed to 𝒩 by replacing uniform bounds by a suitable control by positive harmonic functions. We show several instances where this rule applies, as well as some exceptions. We also briefly discuss the situation for the related Smirnov class.
A classification method for binary predictors
combining similarity measures and mixture
models
Authors: Sylla Seydou N. , Girard Stéphane , Diongue Abdou Ka , Diallo Aldiouma , Sokhna Cheikh
Published: May 2020

In this paper, a new supervised classification method dedicated to binary predictors is proposed. Its
originality is to combine a model-based classification rule with similarity measures thanks to the introduction
of new family of exponential kernels. Some links are established between existing similarity measures
when applied to binary predictors. A new family of measures is also introduced to unify some of the existing
literature. The performance of the new classification method is illustrated on two real datasets (verbal
autopsy data and handwritten digit data) using 76 similarity measures.
Circolazione e vendita della Syngraphe di Anassagora (Plat. Apol. 26d-e)
Authors: Caroli Menico
Published: May 2020

The price ("a drachma at most'') at which a copy of Anaxagoras' Σνγγραφή is sold, in Plat. Apol. 26d-e, is problematic in its real meaning. The difficulty of fixing an overall picture is determined by the fragmentation of the arguments in dozens of commentaries ad loc. First of all, it is necessary to take into account variables (essential for a correct interpretation of this price), such as the cost of the papyrus, especially in epigraphical evidence relating to different moments of Greek economy, and alternative forms of κτῆσις βιβλίων.
Una nuova testimonianza su Senocrate
Authors: Verde Francesco
Published: May 2020

The present short note focuses on Cicero’s De finibus IV 18, 51, a passage which preserves a testimony on Xenocrates (quoted here as magister of Polemon), neglected by the editors of the fragments of Academy’s second scholarch
Esencia, definición y la tesis de identidad en Aristóteles, Metaphysica Z 4-6
Authors: Mié Fabián
Published: May 2020

To clarify Aristotle’s “Identity Thesis” in Metaphysics Z 6, according to which each strictly definable item must be identical to its own essence (1031a15-16, 1032a4- 6), I show that it is a simple corollary of some “logical” theorems drawn from the Organon, which have a direct impact on Z 4’s explanation that identity is based on the possession of essence. As I claim, Z 6’s innovation consists of a clarification about substance as that which - because of having essence - can fulfill the identity- condition. Therefore, Z 6’s argument targets principally “non-Identity” as a consequence of Platonic separation. Further, I argue against the commonly held view that the Identity Thesis stands on the hylomorphism of Z’s later chapters.
Multi-agent grid system Agent-GRID with dynamic load balancing of cluster nodes
Authors: Satymbekov M.N. , Pak I.T. , Naizabayeva L. , Nurzhanov Ch.A.
Published: May 2020

In this study the work presents the system designed for automated load balancing of the contributor by analysing the load of compute nodes and the subsequent migration of virtual machines from loaded nodes to less loaded ones. This system increases the performance of cluster nodes and helps in the timely processing of data. A grid system balances the work of cluster nodes the relevance of the system is the award of multi-agent balancing for the solution of such problems.
On-line moisture content estimation of saw dust via machine vision
Authors: Valta Art , Ruusunen Mika , Leiviskä Kauko
Published: May 2020

The effect of moisture content and feasibility of its estimation in granular material was investigated via machine vision. The test scheme consisted of saw dust samples derived from Norway spruce with moisture content adjusted to three distinct levels. The effect of moisture when present as ice or liquid water was compared. The experimental procedure consisted of pouring the saw dust under video camera recording. The equipment setup consisted of a vibrator feeder and custom-built pouring frame. Still images were extracted with fixed sample time from the recording done during the pouring procedure. From the extracted frames the dynamic behavior of cone profile was investigated via statistical means. It was observed that 2nd standardized moment correlated with moisture content, phase of water and their interaction. Furthermore, 4th standardized moment correlated with moisture content and phase. The 3rd moment was inspected qualitatively from which it was observed that wet samples exhibited tendency to build mass accumulation sites with increasing moisture content. Samples where water was present as ice this was observed in a very small scale with all moisture content values. Corroborated by optical microscopy, these correlations were deduced to be due to liquid bridging in the bulk. Moisture content when present as ice was, however, observed to have a drastic effect on the overall cone shape. Based on these findings, a machine vision application could be feasible way to estimate moisture content on-line in thawed saw dust by using statistical parameters in classification decision making. This would enable cost-effective on-line monitoring of moisture content and a control circuit to be designed.
5G Based Machine Remote Operation Development Utilizing Digital Twin
Authors: Isto Pekka , Heikkilä Tapio , Mämmelä Aarne , Uitto Mikko , Seppälä Tuomas , Ahola Jari M.
Published: May 2020

Remote operations of mobile machinery require reliable and flexible wireless communication. 5G networks will provide ultra-reliable and low latency wireless communications upon whichremote operations, real-time control and data acquisition can be implemented. In this paper we present a demonstration system and first experiments for remote mobile machinery control system utilizing 5G radio and a digital twin with a hardware-in-the-loop development system. Our experimental results indicate that with a suitable edge computing architecture an order of magnitude improvement in delay and jitter over exiting LTE infrastructure can be expected from future 5G networks.
Multi-temporal analysis of an agricultural landscapetransformation and abandonment (Lubietová, Central Slovakia)
Authors: Masný Matej , Zaušková Lubica
Published: May 2020

Socio-political changes in the countries of Easternand Central Europe in the era of socialism had significant effects on agricultural landscape. Collectivisation(1950 - 1970) lost almost all of traditional agricultural landscapes.On the other hand, the phenomenon of agriculturalabandonment started to be significant after 1989. Inthe model area (part of The Polana Biosphere Reserve)these two processes that formed the agricultural landscapestructure were analysed. The analyses were carriedout using orthophotos that represented the landscapestructure in 1949, 1986 and 2006. It was found that almostcomplete extinction of the traditional agricultural landscaperepresented by a mosaic of narrow fields and permanentgrasslands occurred during the period. At the sametime, increasing trend of abandonment processes was observed.In 2006, non-forestwoody vegetation covered 48%of agricultural land.Natural reforestation as the final stageof agricultural abandonment extended to 46% on the formeragricultural land in 2006. Abandonment processeswere the most significant already in the period of socialistagriculture. To describe the changes, landscape metricssuch as Number of patches (NP), Mean patch size (MPS),Patch size standard deviation (PSSD) and Mean shape index(MSI) were used.
A new statistical approach to the geochemical systematics of Italian alkaline igneous rocks
Authors: Ambrosio Francesco Antonio
Published: May 2020

The ultra-alkaline rocks have exotic features that frustrated many attempts to group them in a single classification diagram. A consistent classification would be very useful to define a possible consanguinity, an argument that feed a living debate. This paper investigates the petrologic characteristics of the Cenozoic Italian ultra-alkaline rock-suite using -Rank Entropy Anentropy (RHA) and Principal Component Analysis (PCA)-. The RHA formula is the succession of component’s symbols arranged according to the diminishing of their elemental content in the analysis (whole rock composition). Other two parameters considered are an expression of the anentropy and entropy of the system. The PCA allows the definition of new latent variables based on geochemical compositions through linear combinations of the major oxides. Using both statistical methods was possible to create discrete groups of rock-types, associated by genetic relationship. The groups plotted in the Mg-Ca-Al ternary diagram depicts two main evolutionary arrays. We interpret the chemical variance in term of a general magmatic processes based on immiscibility and crystal fractionation. A comparison with similar association worldwide give a more general prospective to the magmato-tectonic assignment of these rocks, which is highly controversial in Italy.
Bitcoin’s Identity Crisis and the Prospect of Trustless Money
Authors: Zamaria Alain
Published: May 2020

Whether it is legally treated as a digital property, a commodity or a security, bitcoin’s identity crisis is mainly caused by its contradictions as a trustless monetary project. The paper argues that bitcoin’s trustlessness is a confusing concept that accounts for its legal and monetary troubles. As explicated by monetary sociologists and economists, money is based on a complex trust architecture. By questioning the interplay between code, trust and law in the monetary realm, the paper aims to enlighten the philosophy of bitcoin’s monetary project, the current trends, and some potential developments for bitcoin and distributed ledger technologies.
Coumarin sulfonamide derivatives: An emerging class of therapeutic agents
Authors: Irfan Ali , Rubab Laila , Rehman Mishbah Ur , Anjum Rukhsana , Ullah Sami , Marjana Mahwish , Qadeer Saba , Sana Sadia
Published: May 2020

Coumarin sulfonamide is a heterocyclic pharmacophore and an important structural motif which is a core and integral part of different therapeutic scaffolds and analogues. Coumarin sulfonamides are privileged and pivotal templates which have a broad spectrum of applications in the fields of medicine, pharmacology and pharmaceutics. Coumarin sulfonamide exhibited versatile and myriad biomedical activities such as anti-bacterial, antiviral, antifungal, anti-inflammatory and anti-cancer. This review article focuses on the structural features of coumarin sulfonamide derivatives in the treatment of different lethal diseases on the basis of structure-activity relationships (SAR). The plethora of research cited in this review article summarizes and discusses the various substitutions around the coumarin sulfonamide nucleus which have provided a wide spectrum of biological activities and therapeutic potential that has proved attractive to many researchers looking to exploit the coumarin sulfonamide skeleton for drug discovery and the development of novel therapeutic agents.
Synthesis and characterization of novel biological tetracoumarin derivatives bearing ether moieties
Authors: Behzadi Soheila Asadpour , Sheikhhosseini Enayatollah , Ahmadi Sayed Ali , Ghazanfari Dadkhoda , Akhgar Mohammadreza
Published: May 2020

A series of novel tetracoumarin derivatives (3a-f) were prepared using the reaction of ether functionalized dibenzaldehyde with 4-hydroxycoumarin in the presence of sodium acetate. The structure of compounds was validated by IR, NMR, and CHN analyzes. Antimicrobial (antibacterial and antifungal) activity was studied on the basis of the minimum bactericidal concentration, minimum inhibitory concentration and inhibitory zone diameter. Favorable biological activity was found in compound3f.
Core 1 O-N-acetylgalactosamine (O-GalNAc) glycosylation in the human cell nucleus
Authors: Cejas Romina B. , Garay Yohana C. , de la Fuente Sofia , Lardone Ricardo D. , Irazoqui Fernando J.
Published: May 2020

Glycosylation is a very frequent post-translational modification in proteins, and the initiation of O-N-acetylgalactosamine (O-GalNAc) glycosylation has been recently described on relevant nuclear proteins. Here we evaluated the nuclear incorporation of a second sugar residue in the biosynthesis pathway of O-GalNAc glycans to yield the terminal core 1 glycan (C1G, Galβ3GalNAcαSer/Thr). Using confocal microscopy, enzymatic assay, affinity chromatography, and mass spectrometry, we analyzed intact cells, purified nuclei and soluble nucleoplasms to identify the essential factors for C1G biosynthesis in the cell nucleus. The enzyme C1GalT1 responsible for C1G synthesis was detected inside the nucleus, while catalytic activity of C1Gal-transferase was present in nucleoplasm and purified nuclei. In addition, C1G were detected in the nucleus inside of intact cells, and nuclear proteins exposing C1G were also identified. These evidences represent the first demonstration of core 1 O-GalNAc glycosylation of proteins in the human cell nucleus. These findings reveal a novel post-translational modification on nuclear proteins, with relevant repercussion in epigenetic and chemical biology areas.
Tragedies of the Capitalocene
Authors: Arons Wendy
Published: May 2020

The idea of the “Anthropocene” is rapidly gaining currency as an ecocritical lens through which to view theater and performance. But as a lens for critical analysis, the concept of the “Anthropocene” is problematic, primarily because it fails to differentiate among humans, many of whom are in conflict precisely because the benefits and costs of the “Age of Man” have been distributed unevenly. Neo-Marxist critics take such conflicts into fuller account in their argument that a better nomenclature and concept for our epoch is the “Capitalocene,” a term that captures the fact that our ecological crises have been precipitated not by humans in some undifferentiated and generalized way, but more specifically by the global spread of capitalism and its socio-economic-ecological injustices. These are also conflicts at the heart of many plays, both historical and recent. This essay offers an overview of a number of works that might productively be categorized as “Tragedies of the Capitalocene,” insofar as they dramatize stories that trace the dynamics of “Capitalocene” exploitation of both human and nonhuman resources. Plays considered include Cherríe Moraga’s Heroes and Saints (1992), Rahul Varma’s Bhopal (2001), Kia Corthron’s A Cool Dip in the Barren Saharan Crick (2010), Annabel Soutar’s Seeds (2012), Robert Schenkkan’s The Kentucky Cycle (1991), and Colleen Murphy’s The Breathing Hole (2017).
Bis-γ-carbolines as new potential multitarget agents for Alzheimer’s disease
Authors: Makhaeva Galina F. , Shevtsova Elena F. , Aksinenko Alexey Y. , Kovaleva Nadezhda V. , Boltneva Natalia P. , Lushchekina Sofya V. , Rudakova Еlena V. , Pushkareva Elena A. , Serkova Tatyana P. , Dubova Lyudmila G. , Shevtsov Pavel N. , Sokolov Vladimir B. , Radchenko Eugene V. , Palyulin Vladimir A. , Bachurin Sergey O. , Richardson Rudy J.
Published: May 2020

A new series of homobivalent Dimebon analogs, bis-γ-carbolines with alkylene, phenylenedialkylene, and triazole-containing spacers, was synthesized. Doubling the γ-carboline pharmacophore increased inhibitory potency against acetylcholinesterase (AChE) compared with Dimebon, while keeping Dimebon’s anti-butyrylcholinesterase activity; therefore, leading to inversion of selectivity. Molecular docking revealed the reasons for the increased anti-AChE activity and ability to block AChE-induced aggregation of β-amyloid for bis-γ-carbolines, which became double-site inhibitors of AChE. Conjugates with ditriazole-containing spacers were the most active antioxidants in both the ABTS-test and prevention of lipid peroxidation in brain homogenates without inhibiting the mitochondrial permeability transition (MPT). Conjugates with alkylene (4a–d), phenylenedialkylene (4e), and monotriazole (8) spacers were less active as antioxidants but prevented induction of the MPT and increased the calcium retention capacity of mitochondria. Lead compound 4e showed neuroprotective potential in a cellular calcium overload model of neurodegeneration. Computational studies showed that all the bis-γ-carbolines were expected to have high values for intestinal absorption and very good blood-brain barrier permeability along with good drug-likeness. Overall, the results showed that new homobivalent Dimebon analogs exhibit an expanded spectrum of biological activity and improved pharmacological properties, making them promising candidates for further research and optimization as multitarget agents for Alzheimer’s disease treatment.
TouchYou: A wearable touch sensor and stimulator for using our own body as a remote sex interface
Authors: Gomes Leonardo Mariano , Wu Rita
Published: May 2020

In this article, we present TouchYou, a pair of wearable interfaces that enable
affective touch interactions with people at long-distance. Through a touch-sensitive
interface, which works by touch, pressure and capacitance, the body becomes the own
input for stimulating the other body, which has a stimulation interface that enables
the feeling of being touched. The person receives an electrical muscle stimulation,
thermal and mechanical stimulation that react depending on the touch sensed by the
first interface. By using the TouchYou, people can stimulate each other, using their
own body, not only for sexual relations at a distance but for the production of
affection and another way of feeling. We discuss the importance of the touch for
human relationships, the current state of the art in haptic interfaces and how the
technology can be used for the affection remote transmission. We present the design
process of the TouchYou sensitive and stimulation interfaces, with a contribution of
a method for developing custom touch sensors, we explore usage scenarios for the
technology, including sex toys and sex robots and we present the concept of using the
body as a remote sex interface.
Why Digital-Era Political Marketing is Not the Death Knell for Democracy: On the Importance of Placing Political Microtargeting in the Context of Party Competition
Authors: König Pascal D.
Published: May 2020

Political microtargeting has been depicted as a severe danger for democratic representation. It is said to fragment the electorate, help manipulate voters, and make politics overall less responsive and inclusive. However, the present paper aims to show why these are not general consequences to be expected from political microtargeting. It argues that a greater consideration needs to be given to context for a more differentiated understanding of microtargeting. The paper adds to existing research by situating political microtargeting within research on party politics. First, it shows that based on core assumptions about party competition and the strategic incentives it involves, one would not expect that microtargeting practices undermine democratic representation. Major constraints resulting from party competition hardly allow parties to be less responsive and inclusive when employing microtargeting. Second, the presence of such constraints furthermore depends on the larger political and institutional context that shapes the intensity of competition.
Rurality and Party System Fragmentation in the Nigerian Presidential Elections of the Fourth Republic
Authors: Nwankwo Cletus Famous
Published: May 2020

This paper examines the effect of rurality on party system fragmentation in the Nigerian presidential elections of the fourth republic. The findings show that party system fragmentation (PSF) has been characteristically low in the Nigerian presidential elections and rurality does not significantly predict party system fragmentation. Rurality has a negative effect on PSF in all the elections studied except the 2003 election but only significant in the 2011 poll. Thus, the paper cast doubt on previous studies that indicate that striking rural-urban differences manifest in party system fragmentation in African elections and attribute it to previous studies’ measure of rurality. The paper argues that the use of a composite measure of rurality instead of singular measures of rurality might provide better analysis that helps us understand the effect of rurality on party systems. Also, it argues that in the study of the rural-urban difference in voting behaviour or political behaviours more broadly, data should be aggregated based on cities and non-city areas because cities have distinctive urban characters compared with non-city places. Analyses done on states or constituencies level may not reveal the rural-urban difference because states and constituencies usually have a mix of rural and urban population and other characteristics.
On the uniformity of distribution of Farey fractions
Authors: Stakėnas Vilius
Published: May 2020

Let F x be the set of nonnegative rationals m\n with 0 < n < x and (m, n) = 1. For some fixed interval I ⊂ (0;+∞), I = (λ1;λ2) let F (u|x, I) = #(Fx ∩ (λ1;λ1 + u(λ2 - λ1))/#(Fx ∩ I). The paper deals with the estimation of discrepancy |F (u|x, I) - u|, 0 < u < 1.
Analysis of asymptotics for a model of nonlinear oscillations of the absolute elastic weightless string
Authors: Lavcel Olga , Krylovas Aleksandras
Published: May 2020

The mathematical model of string nonlinear oscillations is presented. To found the asymptotic solution of the problem an averaging scheme was constructed in cited latest work of the second author. In this paper a methodology for construction special form soliutions of the system is proposed.
A course of calculus at technical university
Authors: Banys Rimas
Published: May 2020

A few remarks concerningteaching calculus at technicaluniversity are stated.Some examples are provided.
Composite indicators – methodology and practical aspects
Authors: Rukšėnaitė Jurga
Published: May 2020

In this paper methodology of construction Composite Indicators is described. Data standardisation and ranking procedures are proposed. Results of modelling irregular component using different ARIMA models are described.
Elimination of loop-check for logic of idealized knowledge
Authors: Pliuškevičienė Aida
Published: May 2020

In the paper loop-check-free sequent calculus for logic of idealized knowledge is presented. To obtain termination of derivation indices and marks are used instead of history.
Termination of derivations for minimal tense logic
Authors: Pliuškevičius Regimantas
Published: May 2020

It is known that loop checking and backtracking are extensively used in various non-classical logics. An efficient loop checking is obtained using a technique based on histories. In the paper a method for elimination of loop checking in backward proof search for minimal tense logic Kt is proposed. To obtain termination of derivation indices and marks are used instead of history.
On a parameter adaptive self-organizing system in the presence of large outliers in observations
Authors: Pupeikis Rimantas
Published: May 2020

The aim of the given paper is development of a minimum variance control (MVC) approach for a closed-loopdiscrete-time linear time-invariant (LTI) system when the parameters of a dynamic system as well as that of a controller are not known and ought to be estimated by processing observations in the case of additive Gaussian noise on the output with contaminating outliers uniformly spread in it. Afterwards, the current value of the control signal is found in each operation, and it is used to generate the output of the system. The results of numerical simulation by computer are presented and discussed here, too.
Asymptotic distributions of the number of restricted cycles in a random permutation
Authors: Kargina Tatjana
Published: May 2020

The value distribution of additive functions defined on the symmetric group with respect to the Ewens probability is examined. For the number of cycles with restricted lengths, we establish necessary and sufficient conditions under which the distributions converge weakly to a limit law.
Awareness and Usage of Reference Management Software: Perspectives of Faculty Members of University of Ilorin Nigeria
Authors: Adeyemi Ismail Olatunji , Sulaiman Kabir Alabi , Akanbi Lawal Mohammed
Published: May 2020

This study examined the awareness and usage of reference management software by faculty members of the University of Ilorin. Descriptive survey method was adopted for the study. The Web-based questionnaire was used to collect data for the study. The total population of the study is 1,496 people. From which the sample size of 306 was selected using Raosoft sample size calculator and total responses of 98 was returned, which represents the unit of analysis. Hence, the response rate for the study is 32%. The findings of the study revealed that EndNote and Mendeley are the most used reference management software by faculty members of the University of Ilorin (UNILORIN). Results show that faculty members were aware of EndNote and Mendeley to great extent. It was found that there is low usage of reference management software among faculty of the University of Ilorin; and that most of the faculty members have never used ProCites, Bookends, Papers and Qiqqa. It was concluded that there is a positive significant relationship between awareness and usage of reference management software by faculty members. It was recommended that faculty members should be trained on how to make use of the most used reference management software.
The Manifestation of Monster and the Emotional Repression in Jennifer Kent’s The Babadook (2013)
Authors: Chusna Inayatul , Ansyahputri Anggita Rizkiarachma , Fikri Avi Ainul , Rafli Muhammad
Published: May 2020

The purpose of this research is to explore the emotional state of the main character, Amelia, in The Babadook film. The film portrays how Amelia deals with her loss and how the monster Babadook represents the repressed feeling of loss. This research analyses the emergence of the Babadook, how it affects her, and how her behaviors are considered as melancholia by using qualitative method and the theory of psychoanalysis, Mourning and Melancholia by Sigmund Freud (1917). The research finds that the eerie monster haunts Amelia whenever she is confronted to her repressed emotion: grief and self- loathing. The Babadook monster is the manifestation of grief and loss. As the monster getting stronger, the sinister presence of the Babadook starts to affect Amelia’s psyche as she is getting more paranoid and more aggressive. She is also unable to show affection toward her son. Moreover, Amelia shows an act of self-destruct by keeping herself from the outside world and unconsciously blaming herself for the death of the husband. Those behaviors indicate that Amelia comes into the state of melancholia. Finally, she manages to overcome the state by accepting the feeling of loss and let herself mourn. The study of this film suggests a way of dealing with trauma and loss by accepting their permanent presence in life.
MASYARAKAT INDONESIA DALAM MENGHADAPI PANDEMI VIRUS CORONA (COVID-19) DAN PERATURAN PEMERINTAH
Authors: Asri Muhammad
Published: May 2020

Covid-19 merupakan penyakit menular yang berpotensi menimbulkan kedaruratan kesehatan masyarakat.Untuk di Indonesia sendiri pemerintah telah memberikan himbauan-himbauan kepada masyarakat dalam mengatasi wabah ini agar berjalan efektif dan efisien. Tetapi pada kenyataannya masih banyak masyarakat Indonesia yang tidak mengindahkan himbauan ini dan pemerintah juga membuat berbagai peraturan terkait dengan pencegahan Covid-19 ini wajib dibentuk dalam Peraturan Pemerintah dan Peraturan Menteri Kesehatan karena kedua peraturan tersebut merupakan peraturan pelaksanaan daripada Undang-Undang Nomor 6 Tahun 2018 tentang Kekarantinaan Kesehatan. Berdasarkan analisis penulis, ada 5 Peraturan Pemerintah yang wajib dibentuk dalam rangka melakukan tindakan penanggulangan dan pencegahan ancaman penyakit yang mudah menular seperti Covid-19 dan ada 11 Peraturan Menteri Kesehatan terkait yang wajib dibentuk dalam rangka mengantisipasi ancaman Covid-19 Oleh karena itu penelitian mengambil dua jenis peraturan tersebut sangat berguna dalam hal mengantisipasi kedaruratan kesehatan yang pada akhirnya menjurus pada kekarantinaan kesehatan masyarakat Indonesia. Kiranya kedua jenis peraturan ini segera dibuat dalam rangka memberi kepastian hukum dalam mencegah menularnya Covid-19 secara meluas.
COVID-19: TINJAUAN MAQASID AL-SHARIAH TERHADAP PENANGGUHAN PELAKSANAAN IBADAH SHALAT DI TEMPAT IBADAH (Hifdz al-Nafs Lebih Utama Dari Hifdz al-Din?)
Authors: Qotadah Hudzaifah Achmad
Published: May 2020

Abstrak            Penyebaran virus berbahaya bernama Covid-19 yang tengah terjadi saat ini telah menciptakan berbagai polemik dan persoalan di tengah kehidupan masyarakat baik persoalan ekonomi, sosial, politik maupun agama khususnya. Misalnya saja, polemik mengenai penangguhan atau larangan mengenai ibadah shalat juma’at ataupun berjamaah di masjid yang mana persoalan tersebut melahirkan berbagai reaksi pro-kontra dari kalangan masyarakat. Masyarakat yang pro menganggap bahwa hal tersebut sebagai bentuk pencegahan dan antisipasi penyebaran virus korona atau Covid-19 yang tengah mewabah. Adapun masyarakat yang kontra terhadap penangguhan tersebut memandang bahwa hifdz al-din (memelihara agama seperti ibadah shalat) lebih utama dari hifdz al-nafs (memelihara jiwa atau nyawa). Oleh sebab itu, tujuan utama penelitian ini ialah untuk menjelaskan tinjauan Maqasid al-Shariah terhadap pembatasan, penangguhan, serta larangan pelaksanaan ibadah shalat Jum’at maupun lainnya semasa terjadi sebuah wabah. Metode yang digunakan penulis dalam penelitian ini ialah dengan menggunakan metode kualitatif penuh serta data dokumentasi yang terkait dengan topik kajian penelitian ini, kemudian dianalisis secara deskriptif.Kata-kata kunci: COVID-19, Maqasid al-Shariah, Shalat, Hifdz al-Din, Hifdz al-Nafs. AbstractThe spread of a deadly epidemic known as Covid-19 has indeed caused several polemics such as economic, social, political and religious issues in particular. For instance, the conflicts regarding ban congregational prayers and also mass gatherings amid coronavirus or Covid-19 pandemic have led to various responses pros and cons amongst the society. The pro assumes that it is indeed a way of preventing as well as anticipate the transmission of Covid-19. Unlike those who disagree with that kind of postponement, they presume that hifdz al-Din (protection of religion) is much more important than hifdz  al-Nafs (protection of life). Furthermore, the key main objective of this research is to describe the postponement or cancelation of Friday prayers and mass gatherings due to coronavirus pandemic based on comprehensive study of maqasid al-shariah. In this research, the researcher uses full qualitative method and documentation related to the topic of this research, which then will be analyze descriptively.Keywords: COVID-19, Maqasid al-Shariah, Salat, Hifdz al-Din, Hifdz al-Nafs.
Peran Keluarga Dalam Mencegah Coronavirus Disease 2019
Authors: Ashidiqie Mughni Labib Ilhamuddin Is
Published: May 2020

AbstrakWabah Covid-19 yang terjadi di Cina telah menjadi pandemi baru karena telah menyebar keberbagai negara, tak terkecuali Indonesia. Karenanya, pemerintah terus berupaya guna memutus mata rantai dari wabah covid-19 ini. Salah satu upayanya ialah dengan menerapkan kebijakan Work from Home (WFH) dengan maksud untuk belajar, bekerja dan beribadah di rumah. Penerapan kebijakan tersebut mengindikasikan bahwa keluarga dapat menjadi garda terdepan untuk mencegah persebaran Covid-19. Disisi lain, keluarga juga memiliki peran dan fungsi yang bisa dilakukan sebagai upaya melawan dan mencegah persebaran wabah Covid-19. Dengan menjalankan peran dan fungsi keluarga tersebut, merupakan suatu gerakan gotong royong nasional antara masyarakat dan pemerintah untuk membasmi, melawan dan memutus persebaran Covid-19, sehingga bangsa Indonesia dapat mengalahkan wabah tersebut dan kembali seperti sediakala.Kata Kunci: Covid-19, Keluarga, Peran, Fungsi
Persepsi Mahasiswa Terhadap Kuliah Daring dimasa Pandemi Corona Virus Disease (COVID-19)
Authors: Aswasulasikin Aswasulasikin
Published: May 2020

Pemerintah Indonesia berusaha terus memutus rantai persebaran Corona Virus Disease (COVID-19) dengan membuat berbagai kebijakan, diantaranya pembatasan sosial berskala besar (PSBB), social distancing, physical distancing, layanan perkantoran dan aktifitas pendidikan dilakukan dari rumah dengan pemberlakuan work from home (WFH). Oleh karena itu aktifitas pembelajaran dilaksanakan melalui pola daring dengan memanfaatkan berbagai platform yang disediakan oleh dalam jaringan internet. Penelitian ini bertujuan untuk menggali informasi terkait respons mahasiswa terkait dengan aktifitas pembelajaran daring yang sudah dilaksanakan selama kurang lebih 3 bulan dengan menggunakan angket respons yang disebar kemahasiswa secara acak. Data yang diperoleh menunjukan bahwa aktivitas daring yang dilaksanakan menjenuhkan dan membosankan, sehingga dihapkan para dosen lebih kreatif dan inovatif dalam memanfaatkan media yang digunakan agar proses pembelajaran lebih menyenangkan. Daring dengan menggunakan berbagai fitur canggih tidak bisa menggantikan peran dosen melalui perkulaiahan tatap muka, karena lebih memberikan motivasi dan semangat kepada mahasiswa untuk belajar dari pada mengikuti kuliah melalui pola daring (online).