bluuebunny/crossref_metadata_2025 huggingface dataset:
Un paesaggio memoriale ricorrente nella Divina Commedia: i fiumi che decorrono dal versante destro e sinistro dell’Appennino
Authors: Tavoni Mirko
Published: November 2017

In Dantes De vulgari eloquentia wird der Kamm des Apennins mit seinen jeweils in Richtung der Adria sowie bis zum Tyrrhenischen Meer laufenden Strömen als Sprachgrenze angesehen zwischen den Mundarten der rechten und der linken Seite Italiens. Der Toskanisch-Emilianische und der Toskana- Romagna Apennin mit ihren im Nordosten in Richtung der Adria, im Südwesten in Richtung des Tyrrhenischen Meeres laufenden Flüssen kehren in Dantes Inferno und Purgatorio mehrfach als Motive wieder, die jeweils unterschiedliche Bedeutungen aufweisen. Der vorliegende Aufsatz beabsichtigt, an Hand der Analyse der einschlägigen Stellen aus der Göttlichen Komödie die folgenden Punkte zu klären: 1) Dantes biographische Erfahrungen aus den ersten zwei Jahren seines Exils in den Gebieten Casentino, Mugello und Romagna, welchen diese wiederkehrende Gedächtnislandschaft zugrunde liegt; 2) die politische Valenz des »von den Apenninen herkommenden Blicks« des exilierten Dichters, der auf der einen Seite in die toskanischen Comuni, auf der anderen in die sich entwickelnden Signorie der Romagna schaut; 3) die Idee der überquellenden Wasserfülle dieses Gebiets, welche in mehreren Stellen des Inferno und des Purgatorio auftritt.
Berg(-Landschaft) bei Dante – mit einem Ausblick auf Boccaccio
Authors: Wolfzettel Friedrich
Published: November 2017

Riassunto

Nella sua concezione del monte del Purgatorio Dante sembra voler ignorare deliberatamente la lunga tradizione di un purgatorio infernale descritta da Jacques Le Goff, per riallacciarsi invece alla tradizione del monte sacro dell’Antico e del Nuovo Testamento. Non a caso, il monte del Purgatorio è coronato dal Paradiso Terrestre. La nuova posizione del monte al confine del mondo, a differenza della tradizione medievale, sottolinea pure la novità di una concezione quasi reale della montagna sacra la cui ascensione viene descritta con un realismo dinamico inaudito fino ad allora. Ma la »montagna bruna« descritta alla fine del celebre canto XXVI dell’Inferno funge anche da simbolo della verticalità tipica della cultura medievale che il grande dantista Giovanni Boccaccio non potrà accettare. Il ripudio della montagna - a favore di un paesaggio erotico della pianura umida e soleggiata - sarà dunque una caratteristica di tutta la sua opera fino al Decameron. Però, alla fine della sua vita, l’autore riprenderà il motivo del monte sacro di Dante per farne, nella sua visione satirica intitolata Corbaccio, il simbolo di una nuova libertà intellettuale nei confronti delle tentazioni erotiche e della schiavitù della carne. Si tratta però di un tentativo di autoliberazione a spese del dinamismo e del realismo della rappresentazione dantesca: il progresso intellettuale viene contrariato dal regresso estetico.
Birgitta and Bernard: Two Saints and Five Old Swedish Fragments in the Danish National Archives
Authors: Adams Jonathan
Published: November 2017

The Danish National Archives in Copenhagen houses several thousand manuscript fragments, the remains of numerous works that were cut up and used in the bindings of later books. The majority of these fragments are written in Latin, Middle Low German, or Danish, although a few in Old Swedish also survive. Five of these Old Swedish fragments are published and discussed in this article. They contain parts of two of St Birgitta’s
The Dark Continent of Modernity: Black Lingerie in Norwegian Comedies in the 1950s
Authors: Iversen Gunnar
Published: November 2017

In Norwegian film comedies in the 1950s, clothes and underwear are used to map out different attitudes to and effects of modernity. In this essay, the film
Reflections on the ‘Administrative, Not Constitutional’ Character of EU Law in Times of Crisis
Authors: Lindseth Peter L.
Published: November 2017

As is broadly recognized, the realm of administrative power greatly expanded over the course the twentieth century (particularly after 1945). This essay argues that this expansion, along with differential conceptions of legitimacy deeply bound up with it, are crucial to understanding not just the modern administrative state but also the nature of EU governance and the law governing its operation. Despite a dominant paradigm that seeks to understand EU governance in autonomously democratic and constitutional terms, the legitimacy of integration as a whole has remained primarily ‘administrative, not constitutional’. The EU’s normative power, like all power of an ultimately administrative character, finds its legitimacy primarily in legal, technocratic and functional claims. This is not to deny that European integration involves ‘politics’ or has profound ‘constitutional’ implications for its member states or citizens. The ‘administrative, not constitutional’ paradigm is meant only to stress that the ultimate grounding of EU rulemaking, enforcement, and adjudication comes closer to the sort of administrative legitimacy that is mediated through national executives, national courts, and national parliaments to a much greater extent than the dominant paradigm supposes. This is the reality that the ‘administrative, not constitutional’ paradigm on EU law has always sought to emphasize, and it is one that is particularly pertinent to the integration process in times of crisis. It is unsurprising, in these circumstances, that the public law of European integration has continually resorted to mechanisms of nationally mediated legitimacy in order to ‘borrow’ legitimacy from the national level. Unless and until Europeans begin to experience democracy and constitutionalism in supranational terms, the ‘administrative, not constitutional’ paradigm suggests that the EU’s judicial doctrines must be adjusted. The purpose should be to address the persistent disconnect between supranational regulatory power and its robust sources of democratic and constitutional legitimacy on the national level.
The Functions of Constitutional Identity Performed in the Context of Constitutionalization of the EU Order and Europeanization of the Legal Orders of EU Member States
Authors: Belov Martin
Published: November 2017

This article provides an analysis of the functions performed by constitutional identity in constitutional discourses of both the EU and its Member States, in the context of emerging post-Westphalian and supranational constitutionalism. The analysis tries to demonstrate that constitutional identity may serve as one of the key normative ideologies, legitimation strategies and ordering schemes of EU constitutionalism. It reasserts through functional analysis the suitability of constitutional identity for organizing and explaining multiple constitutional orders in a non-hierarchical and inclusive way.

The article is based on a socio-legal approach, deliberately avoiding the predominant legal realist and legal positivist discourses. This is due to the fact that a functional analysis presupposes admitting the existence of ideal, legal and socio-legal dimensions of constitutional concepts and institutions and the taking into account of social implications produced by their functioning. The article deliberately takes a constitutionalist stance on the EU and the EU integration. It is focused on the contribution of constitutional identity for the further constitutionalization of the EU from a socio-political and constitutionalist perspective.
The Theory of EU Constitutional Pluralism: A Crisis in a Crisis?
Authors: Pierdominici Leonardo
Published: November 2017

The paper deals with the validity of constitutional pluralism as a constitutional theory for the European Union and a paradigm for the understanding of EU law in the current times of crisis. It reconstructs the way in which constitutional pluralism came to the fore, the different ways in which the theory was presented, and considers historical criticism it has faced. It then looks at the anomalies that, allegedly, cannot be explained today by constitutional pluralism as a paradigm, linked to the current economic and political crises in the Union. The reconstruction of the debate is complemented with reflections on both the descriptive and normative validity of EU constitutional pluralism’s claims.
Anomaly on Superspace of Time Series Data
Authors: Capozziello Salvatore , Pincak Richard , Kanjamapornkul Kabin
Published: November 2017

We apply the G-theory and anomaly of ghost and antighost fields in the theory of supersymmetry to study a superspace over time series data for the detection of hidden general supply and demand equilibrium in the financial market. We provide proof of the existence of a general equilibrium point over 14 extradimensions of the new G-theory compared with the M-theory of the 11 dimensions model of Edward Witten. We found that the process of coupling between nonequilibrium and equilibrium spinor fields of expectation ghost fields in the superspace of time series data induces an infinitely long exact sequence of cohomology from a short exact sequence of moduli state space model. If we assume that the financial market is separated into two topological spaces of supply and demand as the D-brane and anti-D-brane model, then we can use a cohomology group to compute the stability of the market as a stable point of the general equilibrium of the interaction between D-branes of the market. We obtain the result that the general equilibrium will exist if and only if the 14thBatalin–Vilkovisky cohomology group with the negative dimensions underlying 14 major hidden factors influencing the market is zero.
Pasado, presente y futuro de las lenguas originarias de México
Authors: Flores Farfán José Antonio
Published: November 2017

This paper sketches out a number of sociolinguistic themes regarding Mexican indigenous multilingualism, exploring a global sociolinguistic framework to understand the possibilities of continuity of Mexico’s indigenous languages and their different challenges. In pursuit of an understanding of Mexican indigenous sociolinguistic complexity a series of theoretical and methodological as well as historical and empirical traits, together with our own revitalizing efforts vis-à-vis key institutional contexts, are investigated. For this purpose, case study research findings are highlighted (e.g. Nahuatl), findings which also represent different poles of the language shift-retention continuum (e.g. Kiliwa versus Yucatec Maya).
«Romanische Philologie» in Vergangenheit und Gegenwart Deutschlands: ergänzende Anmerkungen zu einem Beitrag von Wolfgang Schweickard
Authors: Kramer Johannes
Published: November 2017

This contribution offers some complements and extensions to Wolfgang Schweickard’s article Sviluppo storico e situazione attuale della «Romanische Philologie» in Germania (ZrP 132, 2016, 922–937).
CaMKIIα Mediates the Effect of IL-17 To Promote Ongoing Spontaneous and Evoked Pain in Multiple Sclerosis
Authors: Hu Xiaoyu , Huang Fang , Wang Zaijie Jim
Published: November 2017

Pain is a common and severe symptom in multiple sclerosis (MS), a chronic inflammatory and demyelinating disease of the CNS. The neurobiological mechanism underlying MS pain is poorly understood. In this study, we investigated the role of Ca2+/calmodulin-dependent protein kinase IIα (CaMKIIα) in driving chronic pain in MS using a mouse experimental autoimmune encephalomyelitis (EAE) model. We found that spinal CaMKIIα activity was enhanced in EAE, correlating with the development of ongoing spontaneous pain and evoked hypersensitivity to mechanical and thermal stimuli. Prophylactic or acute administration of KN93, a CaMKIIα inhibitor, significantly reduced the clinical scores of EAE and attenuated mechanical allodynia and thermal hyperalgesia in EAE. siRNA targeting CaMKIIα reversed established mechanical and thermal hypersensitivity in EAE mice. Furthermore, CaMKIIαT286A point mutation mice showed significantly reduced EAE clinical scores, an absence of evoked pain, and ongoing spontaneous pain when compared with littermate wild-type mice. We found that IL-17 is responsible for inducing but not maintaining mechanical and thermal hyperalgesia that is mediated by CaMKIIα signaling in EAE. Together, these data implicate a critical role of CaMKIIα as a cellular mechanism for pain and neuropathy in multiple sclerosis and IL-17 may act upstream of CaMKIIα in the generation of pain.

SIGNIFICANCE STATEMENTPain is highly prevalent in patients with multiple sclerosis (MS), significantly reducing patients' quality of life. Using the experimental autoimmune encephalomyelitis (EAE) model, we were able to study not only evoked hyperalgesia, but also for the first time to demonstrate spontaneous pain that is also experienced by patients. Our study identified a role of spinal CaMKIIα in promoting and maintaining persistent ongoing spontaneous pain and evoked hyperalgesia pain in EAE. We further demonstrated that IL-17 contributes to persistent pain in EAE and functions as an upstream regulator of CaMKIIα signaling. These data for the first time implicated CaMKIIα and IL-17 as critical regulators of persistent pain in EAE, which may ultimately offer new therapeutic targets for mitigating pain in multiple sclerosis.
Abordagens metodológicas que auxiliam na identificação química da cocaína apreendida no Brasil
Authors: Freitas Isaias da Silva , Da Silva Caroline de Noronha Marinho , Barbosa Antony de Paula
Published: November 2017

O tráfico de drogas proscritas no Brasil tem aumentado consideravelmente. Um dos reflexos desse crescimento se dá pelo quantitativo apreendido pelos órgãos de segurança pública de drogas sintéticas, canabinóides e, em sua maioria, por cocaína. O Brasil encontra-se geograficamente localizado em uma área onde o cultivo de espécies da família Erythroxylaceae é beneficiado, além disso, faz fronteiras com os principais países produtores de cocaína no mundo, o que dificulta, sobremaneira, o combate ao seu tráfico. As polícias federal e civil têm identificado, constantemente, novos fornecedores e novos locais de refino de cocaína, logo, a identificação das rotas de tráfico, origem geográfica e dos seus distribuidores torna-se cada vez mais complexa exigindo dos órgãos de segurança pública e da comunidade forense em geral um melhor aprimoramento de suas metodologias de identificação e quantificação, de forma a fornecerem informações conclusivas para o combate ao seu tráfico. Assim, nesse trabalho, foram avaliadas as principais abordagens metodológicas que contribuem para a elucidação da identificação das amostras de cocaína apreendida no país.
Human sex hormone-binding globulin does not provide metabolic protection against diet-induced obesity and dysglycemia in mice
Authors: Sofer Yael , Nevo Nava , Vechoropoulos Michal , Shefer Gabi , Osher Etty , Landis Nathan , Tordjman Karen , Hammond Geoffrey L , Stern Naftali
Published: November 2017

Background

Sex hormone-binding globulin (SHBG) is the main transporter of sex hormones in most vertebrates. Low SHBG levels have been linked to increased risk for diabetes and metabolic syndrome. Polymorphisms of the SHBG gene linked to low SHBG protein levels also strongly predicted increased risk of type 2 diabetes, thus raising the possibility that SHBG may play a role in the pathogenesis of insulin resistance and diabetes.

Aim

To examine whether expression of human SHBG in mice may ameliorate the development of diabetes and metabolic syndrome in response to a high-fat diet (HFD).

Methods

Transgene mice expressing a human SHBG transgene (SHBG+) (N = 10/11; males/females) and their wild type littermates (N = 12/8; males/females) were fed HFD for 4.5 months.

Results

HFD induced comparable obesity in control and SHBG+ mice. Male transgenes had higher muscle mass after 2–3.5 months HFD (0.43 ± 0.028 (n = 4) vs 0.38 ± 0.053 g (n = 7), P = 0.05). Fasting blood glucose, as well as insulin or HOMA-IR, was not different in transgenic vs wild-type males after 4–5 months HFD. Female transgenes had higher fasting glucose (152 ± 29 (n = 7) vs 115 ± 27 mg/dL, P = 0.01 (n = 8)), but mean insulin and HOMA-IR were not different. Likewise, insulin tolerance test and intra-peritoneal glucose tolerance test (GTT) were not different. Finally, SHBG+ mice were not different from controls in terms of liver enzymes, serum triglyceride levels and blood pressure.

Conclusion

In mice with diet-induced obesity, human SHBG did not protect against development of obesity or dysglycemia.
The next step: mechanisms driving adrenocortical carcinoma metastasis
Authors: Lalli Enzo , Luconi Michaela
Published: November 2017

Endocrine tumors have the peculiarity to become clinically evident not only due to symptoms related to space occupation by the growing lesion, similarly to most other tumors, but also, and most often, because of their specific hormonal secretion, which significantly contributes to their pathological burden. Malignant endocrine tumors, in addition, have the ability to produce distant metastases. Here, we critically review the current knowledge about mechanisms and biomarkers characterizing the metastatic process in adrenocortical carcinoma (ACC), a rare endocrine malignancy with a high risk of relapse and metastatization even when the primary tumor is diagnosed and surgically removed at an early stage. We highlight perspectives of future research in the domain and possible new therapeutic avenues based on targeting factors having an important role in the metastatic process of ACC.
Cardioprotection of dapagliflozin and vildagliptin in rats with cardiac ischemia-reperfusion injury
Authors: Tanajak Pongpan , Sa-nguanmoo Piangkwan , Sivasinprasasn Sivaporn , Thummasorn Savitree , Siri-Angkul Natthaphat , Chattipakorn Siriporn C , Chattipakorn Nipon
Published: November 2017

Sodium-glucose cotransporter 2 inhibitor (SGLT2-i) effects on cardiac ischemia/reperfusion (I/R) injury are unclear. Unlike SGLT2-i, dipeptidyl peptidase 4 inhibitors (DPP4-i) have shown effective cardioprotection in cardiac I/R injury. We aimed to investigate whether SGLT2-i reduces myocardial dysfunction and myocardial injury to a greater extent than DPP4-i in obese insulin-resistant rats with/without cardiac I/R injury. The high-fat (HF) diet-induced obese insulin-resistant rats were divided into 4 groups and received the following treatments for 28 days: vehicle (HFV); vildagliptin at a dosage of 3 mg/kg/day (HFVil); dapagliflozin at a dosage of 1 mg/kg/day (HFDa) and combination drugs (HFDaVil). At the end, I/R injury was induced by a 30-min left anterior descending coronary occlusion and 120-min reperfusion. Dapagliflozin showed a greater efficacy than vildagliptin in improving the metabolic impairments, low frequency/high frequency (LF/HF) ratio, systolic blood pressure and left ventricular (LV) function in comparison to HFV rats. In cardiac I/R injury, dapagliflozin had a greater efficacy than vildagiptin in decreasing mitochondrial DRP1, cleaved caspase 3, LV dysfunction and infarct size in comparison to HFV rats. However, the combined therapy showed the greatest efficacy in attenuating LV dysfunction, mitochondrial DRP1 and infarct size in comparison to HFV rats. In conclusion, dapagliflozin has a more pronounced effect than vildagliptin in obese insulin-resistant rats for the improvement of LV function. In rats with cardiac I/R injury, although dapagliflozin had a greater efficacy on cardioprotection than vildagliptin, the combined therapy exerted the highest cardioprotective effects potentially by reducing mitochondrial fission.
Effect of FDA Investigation on Opioid Prescribing to Children After Tonsillectomy/Adenoidectomy
Authors: Chua Kao-Ping , Shrime Mark G. , Conti Rena M.
Published: November 2017

BACKGROUND:

In August 2012, the Food and Drug Administration investigated the safety of codeine use by children after tonsillectomy and/or adenoidectomy, culminating in a black box warning in February 2013. The objective of this study was to evaluate the association between the investigation and opioid prescribing to children undergoing these surgeries.

METHODS:

We identified 362 992 privately insured children in the 2010–2015 Truven MarketScan Commercial Claims and Encounters database who underwent tonsillectomy and/or adenoidectomy. Using an interrupted time series design, we estimated level and slope changes in the proportion of children with ≥1 prescription fills for codeine and ≥1 fills for an alternative opioid, such as hydrocodone, within 7 days of surgery.

RESULTS:

The investigation was associated with a significant −13.3 (95% confidence interval: −14.5 to −12.1) percentage point level change in the proportion of children with ≥1 prescription fills for codeine after tonsillectomy and/or adenoidectomy. Despite this drop, 5.1% of children had ≥1 prescription fills for codeine in December 2015. The investigation was not associated with significant level changes in alternative opioid prescribing, although the proportion of children receiving alternative opioids increased during the study period because of other factors.

CONCLUSIONS:

The Food and Drug Administration investigation substantially decreased codeine prescribing to children after tonsillectomy and/or adenoidectomy. However, 1 in 20 children undergoing these surgeries were still prescribed codeine in December 2015 despite its well-documented safety and efficacy issues.
IDENTIFICANDO FRAGILIDADES E POTENCIALIDADES: UM BREVE PANORAMA DA DISCIPLINA “GEOGRAFIA APLICADA AO TURISMO” NA EAD/IFRN
Authors: Nascimento Gracileide Ferreira , Oliveira Elizângela Justino
Published: November 2017

Este artigo tem como objetivo identificar as principais dificuldades do cursista na disciplina “Geografia Aplicada ao Turismo”, na Educação a Distância - EAD/IFRN, no semestre 2013.2. As inquietações surgiram ao longo da disciplina quando percebemos o número considerável de estudantes que não realizavam as atividades. Para a produção do estudo, fizemos uma breve consideração sobre a educação profissional e o conceito de educação a distância a partir de teóricos. Utilizamos um formulário enviado na plataforma moodle para ser respondido pelos estudantes. Dos 43 matriculados na disciplina em foco,27atenderam ao preenchimento do formulário. Destes, 74,07% eram do sexo feminino e 25,93% do sexo masculino. Quanto à profissão/ocupação, foi comprovado que a maioria - 48% - era de estudantes, 8%, de donas de casa e funcionários públicos, e 36% tinham outras ocupações. Apesar de se declarar estudante, a maioria - 67% - afirmou trabalhar enquanto estudava e 37% somente estudavam. No relato sobre as suas dificuldades durante o curso, foi detectado o fator “tempo”, por terem outros afazeres e por desempenharem outras funções. Pensamos que é preciso ser realizado com os estudantes um trabalho de conscientização e educação tanto de otimização do tempo, quanto do compromisso e da importância da qualificação profissional no mercado de trabalho, já que estes não relataram dificuldades nem quanto ao feedback ou ao manuseio no moodle e nem tampouco falta de motivação nas atividades propostas.
PRODUÇÃO CIENTÍFICA SOBRE ANÁLISE DO DISCURSO NA ENFERMAGEM E REFERENCIAIS TEÓRICOS MAIS UTILIZADOS
Authors: Adão Isabel Cristina , Oliveira Ernani Coimbra , Andrade Stela Cabral , Gonçalves José Carlos
Published: November 2017

O objeto deste estudo se constituiu nas evidências científicas sobre a produção científica nacional e internacional da Enfermagem sobre a análise do discurso e os referenciais teóricos mais utilizados. Considerando a natureza do objeto e a problemática apresentada, teve-se como questão norteadora desta pesquisa: Quais as contribuições da análise do discurso para a Enfermagem e quais os autores mais utilizados ao se abordar a análise do discurso na Enfermagem? Ante o exposto, nosso objetivo foi identificar e analisar por meio da literatura científica nacional e internacional, as contribuições científicas da análise do discurso para a Enfermagem e os autores mais utilizados para essa finalidade. Trata-se de um estudo descritivo e exploratório. A apresentação dos resultados e a discussão dos dados obtidos foram feitas de forma descritiva e foram construídas as categorias de análise relacionadas aos referenciais teóricos mais utilizados, as quais apontaram a Análise do Discurso Francesa como a mais prevalente, sendo Michel Foucault o autor mais citado
CONSTRUÇÃO DE UM CALORÍMETRO PARA MEDIÇÃO DE EFICIÊNCIA TÉRMICA NA SOLDAGEM
Authors: Ziegler Cristiano , Sinigaglia Tiago , Patias Alessandro José
Published: November 2017

Calorímetro é um sistema utilizado para a medição de transferência de calor. O objetivo do presente trabalho consiste na construção de um calorímetro para medir a eficiência térmica na soldagem que foi desenvolvido nos laboratórios da Faculdade Horizontina-FAHOR. O calorímetro consiste em duas caixas isoladas termicamente sendo que em uma delas está acondicionada uma tubulação aletada, que tem a função de coletar o calor do experimento. Após a construção do calorímetro foram realizados testes experimentais para validação dos mesmos. Dois testes foram realizados primeiramente com peças aquecidas para verificação da eficiência térmica do calorímetro. Posteriormente, foi realizado um teste com soldagem MAG para definição do rendimento térmico do calorímetro. No primeiro experimento com peças aquecidas foi determinada que a eficiência térmica do calorímetro foi de 92,8%, no segundo teste, a eficiência térmica do calorímetro foi de 91,72%. No experimento de soldagem foi encontrado um rendimento térmico de 88,73%. Por este motivo, pode-se afirmar que o objetivo ao qual o trabalho se propôs foi atingido, pois o calorímetro mostrou-se capaz, inclusive, de medir a eficiência térmica de soldagem.
PERCEPÇÃO DOS USUÁRIOS DE BOMBA DE INFUSÃO DE INSULINA NO SUDESTE GOIANO
Authors: Silva André Carlos , SILVA Aline Mirian da , BARROS Mariana Rezende de , SILVEIRA Amanda Oliveira Soares Monteiro , SOUZA Séfara , Leal Geraldo Sadoyama
Published: November 2017

A partir do final do século XX, surgiram grandes avanços tecnológicos no tratamento do diabetes, entre eles destaca-se a Bomba de Infusão de Insulina (BII).  Diante da busca de tratamentos que alcancem um controle glicêmico adequado passível de prevenir as complicações crônicas e com melhor qualidade de vida, percebeu-se a necessidade de avaliar a satisfação com o tratamento (ST) BII. A amostra selecionada foi composta por 10 indivíduos de um total de 12 usuários de BII que responderam um questionário sobre ST. A maioria dos pacientes entrevistados apresentou alto percentual em relação ao grau de satisfação com a BII. Por outro lado, os altos custos e a distorção da imagem corporal destacaram-se como fatores negativos em relação a BII. Apesar da BII ser uma inovação tecnológica no tratamento de pacientes diabéticos, ainda é subutilizada principalmente pelos custos elevados. Dessa forma é fundamental a realização de mais pesquisas na área, para que seja possível demonstrar custo-benefício do tratamento com a BII, possibilitando maior abrangência dessa terapia para a população diabética, assim como disponibilização de dispositivos mais confortáveis.
IMPACTO DE FATORES METEOROLÓGICOS SOBRE AS CONCENTRAÇÕES DE OZÔNIO MODELADOS POR ANÁLISE DE SÉRIES TEMPORAIS E MÉTODOS ESTATÍSTICOS MULTIVARIADOS
Authors: Souza Amaury de , Santos Debora A.S. , Aristone Flavio , Kova?-Andri? Elvira , Markovi? Berislav , Matasovi? Brunislav , Pavao Hamilton G. , Pires Jose C M , Ikefuti Priscilla V
Published: November 2017

O objetivo desta pesquisa foi de desenvolver um modelo para prever as concentrações de ozônio em função das variáveis climáticas. As medidas de concentração do ozônio foram realizadas na Universidade Federal de Mato Grosso do Sul, utilizando dados do período de janeiro a dezembro de 2014. As variáveis preditoras referentes ao clima (umidade relativa, velocidade do vento, chuva, aeerossóis, índice de claridade, radiação solar global e temperatura) foram cedidas pela CEMTEC-Campo Grande-MS. Foram realizadas análise de componentes principais (PCA) e análise de regressão linear múltipla (MLR) aplicadas a estas séries temporais. As principais relações observadas nestas análises foram então usadas para obter uma equação de regressão que liga as concentrações de ozônio diurnas com parâmetros climáticos. O modelo desenvolvido é capaz de explicar 99% da variabilidade nas concentrações de ozônio de superfície com um erro de 0,2%?
SÍNTESE DE NANOPARTÍCULAS DE SnO2 DOPADAS COM NÍQUEL PELO MÉTODO HIDROTERMAL ASSISTIDO POR MICRO-ONDAS E SUA UTILIZAÇÃO COMO CATALIZADORES NA OBTENÇÃO DE BIODIESEL
Authors: Oliveira Marcelo Moizinho , Rangel José Hilton Gomes , Vasconcelos Jomar Sales , Longo Elson
Published: November 2017

Devido sua alta estabilidade química, além de seu baixo custo, o dióxido de estanho vem sendo bastante reportado na literatura, bem como sua síntese hidrotérmica associada a micro-ondas. A utilização de catalizadores heterogêneos, na síntese de biodiesel, vem se mostrando bastante promissor, com taxas de conversão acima de 80 %. Este trabalho teve o objetivo de sintetizar o SnO2 dopado com níquel visando sua aplicação como catalisador heterogêneo na transesterificação de óleos vegetais. Os pós obtidos foram caracterizados por difração de raios X, espectroscopia Raman, microscopia eletrônica de varredura e adsorção/dissorção de N2(g) utilizando o método de Brunauer-Emmet-Teller (BET). Os resultados mostraram pós com aglomerados nanométricos e alta área superficial.  Os testes catalíticos mostraram um fator de retenção de 80 % e redução da viscosidade do óleo babaçu de 30,27 mm2s-1 para 6,91 mm2s-1, indicando que o catalizador sintetizado pode ser utilizador na transesterificação de óleos vegetais.
THE CHINESE FOOTBALL DEVELOPMENT PLAN: SOFT POWER AND NATIONAL IDENTITY
Authors: Leite Júnior Emanuel Ferreira , Rodrigues Carlos
Published: November 2017

In April 2016, the People's Republic of China (PRC) launched the "football development plan in the medium and long term (2016-2050)." The Chinese Government's goal is clear: making the Asian country a worldwide football superpower. This article will showhow the Chinese strategy is organized in its three stages, with commitments and goals to be reached at the end of each one of them. Including the President Xi Jinping "three dreams of World Cup" audacious plans: return to dispute the FIFA World Cup, host a World Cup edition and, finally, win a World Cup to thus consolidate the country 's football power in the most popular sport on the planet. The article also intents to demonstrates how the Chinese state induces private investment in football and sports industry. Showing that the large Chinese conglomerates have beeing collaborated in a crucial manner so that the government achieves the objectives outlined in its plan. And while China is moving towards the development of the most popular sport on the planet, the article brings to the theoretical discussion issues such as soft power and sport's influence, especially football, in the identity and national pride. Brought to a conclusion that the Chinese state has taken advantage of the football popularity to exercise 'soft power', strengthening diplomatic ties and placing the country in the Asian and worldwide context, but also to reinforce their people sense of national identity. For this, the article resorts to the bibliographic review, comparative study, in addition to analyzing the football development plan.
POLÍTICA DE FORMAÇÃO DE PROFESSORES: A INGERÊNCIA DOS ORGANISMOS INTERNACIONAIS NO BRASIL A PARTIR DA DÉCADA DE 1990
Authors: Florencio Lourdes Rafaella Santos , Fialho Lia Machado Fiuza , Almeida Nadja Rinelle Oliveira de
Published: November 2017

O trabalho tem como objetivo analisar as atuais concepções sobre a formação docente brasileira, tendo como mote as reformas educacionais empreendidas a partir da década de 1990, as quais se acredita que foram abalizadas por organismos internacionais. Para tanto, exploraram-se as orientações contidas em documentos publicados pelos organismos multilaterais, em particular os que se dedicam à Educação, e também a legislação educacional vigente. O ensaio ampara-se teoricamente em autores como Cury (1996), Evangelista (2014), Freitas (2011, 2013), Frigotto (2013), Leher (1998), Libâneo, Oliveira e Toschi (2012), Shiroma, Moraes e Evagelista (2004),Torres (2001), dentre outros. Como resultado da investigação, pode-se intuir que as atuais políticas educacionais voltadas para a formação de professores no Brasil atendem em muito às recomendações constatadas nas orientações dos organismos internacionais. Compreende-se que as muitas ações e normatizações do sistema educacional brasileiro, incluindo a formação dos profissionais da educação, notadamente a partir do governo de Fernando Henrique Cardoso (1995-2002) e, em certa medida, de seus sucessores presidenciais, Luiz Inácio Lula da Silva (2003-2010) e Dilma Rousseff (2011-2016), tratam de uma continuidade no alinhamento ao projeto neoliberal de construção de um molde genérico e abstrato de Educação para os países periféricos.
MÁS ALLÁ DE LOS DESAFÍOS DEL DECENIO DE LA EDUCACIÓN PARA EL DESARROLLO SOSTENIBLE: UNA REFLEXIÓN NECESARIA
Authors: De Sousa Alexsandra Carvalho , Uceda i Maza Francesc Xavier
Published: November 2017

La temática central del artículo se vincula a las discusiones llevadas a cabo por el Decenio de la Educación para el Desarrollo Sostenible (2005-2014) y tiene el objetivo de presentar las contribuciones del Decenio como herramienta de convergencia internacional que impulsó y fortaleció la comprensión de la educación como herramienta esencial para el desarrollo Sostenible y contribuyó a una percepción holística del estado mundial con la finalidad de generar actitudes y responsabilidades en la dirección del desarrollo sostenible, un modelo de desarrollo que satisface las necesidades del presente sin comprometer las necesidades de las futuras generaciones. Para ello, se discute y problematiza sobre los procedimientos y conceptos que antecedieron el Decenio, sus finalidades y objetivos inspiradores, además de discutir sobre las configuraciones actuales y perspectivas futuras más allá del Decenio de la Educación para el Desarrollo Sostenible.
SHUFFLED FROG LEAPING ALGORITHM AND FEATURE SELECTION FOR IMPROVING RECOGNITION RATE OF PERSIAN HANDWRITTEN DIGITS CLASSIFIER
Authors: Ghanbari Najme , Heidari Mahdi
Published: November 2017

In this paper, Shuffled Frog Leaping Algorithm is used to improve the recognition rate of Persian handwritten digits. In proposed approach, the effective features in increasing the recognition rate are selected using the Binary Shuffled Frog Leaping Algorithm (BSFLA). By selecting the most suitable features from among all extracted features, the recognition rate is improved and computational costs are also decreased. The fitness function in BSFLA is the number of errors in the Fuzzy classifier which its minimum value is desired. The results indicate that Shuffled Frog Leaping algorithm (SFLA) is more efficient
Around the Idea of Compromise. The activity of the Polish Peasant Party „New Liberation” on the forum of the State National Council and Parliament (with a particular emphasis on education)
Authors: Skrzyński Tomasz
Published: November 2017

PSL „New Liberation” tried to win the villages. It highlighted its association with one of the major pre­‑war left­‑wing peasant parties: PSL „Liberation”. Before the war it had gathered many village teachers, focusing its attention on the modernization and development of education. The „New Liberation” declared great concern for the state (including education); it emphasized the importance of religion; it ensured that in the new political realities, an educated peasant „should not be a laughing stock, as it used to be previously, but a citizen enjoying full rights”. The party emphasized the role of peasant educational organizations: „the tremendous importance of this work, which seeks to abolish the eternal harm suffered by the neglected peasant child.” „New Liberation” persuaded the peasants that they should abandon their rivalry with the Communists and Socialists. The aim was to cooperate on equal terms. But, the idea of „New Liberation” to partially represent the interests of the village in the parliament was unreal. The „liberators” failed to notice the insincerity in PPR policy. The aim of this article is to recall the main activities of the Polish Peasant Party “New Liberation” on the forum of the State National Council and Parliament.
Muzyka liturgiczna a nowoczesność
Authors: Botor Henryk Jan
Published: November 2017

W każdej muzycznej epoce pojawiał się pewien rodzaj nowoczesności, który powodował rozwój muzycznego języka. Jednak nowoczesność pojmowana współcześnie rozpoczęła się mniej więcej na początku wieku XX w., szczególnie w malarstwie. Zapoczątkował ją kierunek malarski zwany dadaizmem. Artyści, którzy go tworzyli, nierzadko kierowali się nihilizmem. Dadaizm przerodził się w nowy kierunek, zwany surrealizmem. Jego przedstawicielami byli m.in. Salvador Dali, Giorgio de Chirico, Max Ernst, Marcel Duchamp. Kierunek ten cechował się też buntem artystów przeciwko tradycyjnemu pojęciu piękna i sztuki.Podobny bunt w muzyce nastąpił dopiero na przełomie lat pięćdziesiątych i sześćdziesiątych XX w., w postaci tendencji awangardowych, co spowodowało rozpad tradycyjnego podejścia do tworzenia muzyki. Muzyka liturgiczna w tym czasie zachowała swój tradycyjny język muzyczny, a to zaowocowało większym rozdźwiękiem między Kościołem a kulturą. Kardynał Joseph Ratzinger w swojej książce Nowa pieśń dla Pana porusza i analizuje te zjawiska, przez co książka ta jest znakomitą pozycją pomocną w rozwiązywaniu tych problemów.Znakomitym drogowskazem dla twórców nie tylko muzyki liturgicznej jest List do artystów św. Jana Pawła II, w którym autor porusza sens twórczości. List ten jest też pewnym pomostem między twórcą sztuki współczesnej a Kościołem.Można również próbować stosować pewne współczesne techniki kompozytorskie w liturgii, ze szczególnym uwzględnieniem tych, które dotyczą harmonii i skal muzycznych (np. skale Messiaenowskie). Jednakże należy czynić to z rozwagą, aby nie zakłócić przeżywania liturgii przez wiernych.
Pieśni mszalne ks. Franciszka Walczyńskiego
Authors: Garnczarski Stanisław
Published: November 2017

Pieśni mszalne ks. Franciszka Walczyńskiego są kontynuacją tego gatunku istniejącego od drugiej połowy XVIII w. Kompozytor przejął wybrane teksty z pieśni już istniejących i opatrzył je nowymi melodiami. Pieśni mszalne w twórczości Walczyńskiego to cykle liczące przeważnie od dziewięciu do sześciu części. Warianty tekstowe są nieliczne. Struktura tekstów oparta wyłącznie na budowie stroficznej wykorzystuje zwrotki od ośmio-, siedmio-, sześcio- i w jednej pieśni czterowersowe. Są one w przewadze hetrosylabiczne, wiązane rymami żeńskimi dokładnymi, układającymi się naprzemiennie oraz rzadziej – przylegająco.Pod względem muzycznym pieśni mszalne zawarte w badanym zbiorze ks. Walczyńskiego prezentują układy dwu- i trzyczęściowe, oparte o harmonikę dur­‑moll, formę melodyczną cechującą się szerokim zakresem ambitusu, kierunkiem łukowym i falistym, interwałami sekundowymi. Wszystkie te cechy ukazują wartość artystyczną twórczości muzycznej ks. Walczyńskiego, będącej świadectwem religijnej kultury muzycznej Kościoła katolickiego w Polsce w XIX i w początkach XX w.
„Litania do Marii Panny” Jerzego Lieberta w kantacie Karola Szymanowskiego
Authors: Szczurko Elżbieta
Published: November 2017

Przedmiotem artykułu jest Litania do Marii Panny op. 59 Karola Szymanowskiego, napisana do fragmentów wiersza Jerzego Lieberta. Autorka koncentruje się najpierw na cechach twórczości Lieberta, jako czołowego przedstawiciela poezji religijno­‑filozoficznej dwudziestolecia międzywojennego, wskazując także na ewolucję poglądów filozoficzno­‑religijnych poety, determinujących jego aktywność literacką. Analizie poddany jest najpierw pełen prostoty, nacechowany symbolicznie liryk Lieberta Litania do Marii Panny, stanowiący przykład poezji, w której podmiot „staje się locus transcendentiae”. Kontekst dla wiersza stanowi zarówno litania liturgiczna, jak i litania poetycka, z przykładami wierszy napisanych przed Litanią Lieberta. W dalszej części artykułu autorka skupia się na walorach kantaty Karola Szymanowskiego, uznanej przez samego kompozytora za „może najlepszy utwór, jaki napisał”. Wskazując najpierw na przyczyny inspiracji wierszem Lieberta oraz okoliczności powstania dzieła, autorka przechodzi do charakterystyki cech konstytutywnych kantaty, odnajdując je na poziomie stylu i estetyki, w relacji słowa i muzyki oraz symbolice figur obrazowych i wyrazowych. W interpretacji dzieła pojawiają się odniesienia do analiz innych autorów, m.in. koncepcji Mieczysława Tomaszewskiego, przedstawiającego Litanię jako wcielenie idiomu „franciszkańskiego”.
Ideologia euroregionalizmu
Authors: Muś Anna
Published: November 2017

Europe of the Regions is a political doctrine popular especially in Europe up to this day. Its foundations are created by the ideology, which consists of the faith in European integration and stressing the need for representation of interests of every region, called in the paper Euro‑­regionalism ideology. The paper presents the ideas of Leopold Kohr, Yann Fouéré and Denis de Rougemont. Moreover the paper consists of analysis of their influence on the doctrine, called Europe of Regions, presented among others, by the European Free Alliance.
Cure in Advanced Renal Cell Cancer: Is It an Achievable Goal?
Authors: Sabanathan Dhanusha , Park John J. , Marquez Manuel , Francisco Louise , Byrne Natalie , Gurney Howard
Published: November 2017

Background

Immunotherapy has historically been of interest in the management of metastatic renal cell cancer (mRCC) because of its relative chemoresistance and the reproducible but low incidence of spontaneous remission in metastatic disease. Recently, targeted immunotherapies in the form of checkpoint inhibitors have shown durable responses in approximately 20%–30% of patients with solid tumors, with a much more acceptable side-effect profile. Anti-programmed death receptor 1 (PD-1)/programmed death receptor ligand 1 antibodies rely on the presence of host T cells in the tumor microenvironment to be stimulated in order to activate an antitumor response. The presence of tumor antigens augments this stimulation. This has led to further research into combination therapy with anti-PD-1 inhibitors and radiotherapy, chemotherapy, or targeted therapy with the aim of increasing the response rate to these agents.

Materials and Methods

We describe three cases of patients with mRCC treated with anti-PD-1 antibody therapy in combination with targeted therapy (bevacizumab), anti-cytotoxic T lymphocyte antigen 4 therapy (ipilimumab), or radiotherapy. We perform a comprehensive literature review on combination immunotherapy and the scope for the future.

Results

Two patients had a complete clinical response within 3 months of commencing treatment. The third patient had a further significant response to radiotherapy outside the field of treatment after initial response to anti-PD-1 therapy, which lasted for over 12 months.

Conclusion

We are now in the era of immunotherapy with promising results in select patients. However, the number of complete remissions with single agents are low. This report demonstrates the potential for combination therapy in mRCC to produce complete responses and improved survival rates. Whether these results equate to cure in a subset of patients requires longer follow-up. Further evaluation of dosing regimens, sequencing methods, and biomarkers to select patient population is required to advance this treatment strategy.
Effect of different lengths and dosages of recycled glass fibres on the fresh and hardened properties of SCC
Authors: Mastali Mohammad , Dalvand Ahmad , Sattarifard Alireza R. , Abdollahnejad Zahra
Published: November 2017

An experimental and analytical investigation was carried out to examine the feasibility of using recycled glass fibres in self-compacting concrete (SCC). Different fibre volume fractions (0·5, 1, 1·5 and 2%) and different fibre lengths (10, 20 and 30 mm) were used to assess both the fresh and hardened properties of fibre-reinforced SCCs. The fresh properties were assessed in terms of flowability and viscosity, while the hardened properties of 130 specimens were characterised in terms of ultrasonic pulse velocity, compressive strength, flexural strength and impact resistance. The specimens were thus tested experimentally to characterise their mechanical properties and impact resistance. Backscattered electron images and elemental maps were used to identify the crystalline structure of the cementitious matrix, and energy-dispersive X-ray spectroscopy was employed to determine the qualitative or semi-quantitative chemical compositions of the cementitious mix composition. The surface topography and morphology of the embedded glass fibres in the matrix were also evaluated. The results showed that increasing the volume fraction and length of the recycled glass fibres improved both mechanical properties and impact resistance. Moreover, it was found that the mechanical properties and impact resistance could be linearly correlated to the recycled glass fibre volume fraction.
A Study of the Relationship Between Stock Prices for Tourism Business-Related Companies and Macroeconomic Variables
Authors:   The Tourism Sciences Society Of Korea, Shin Yong-Jae , Hong Mi-Young
Published: November 2017

We examined the relationship between stock prices for tourism business-related companies and macro-economic variables in Korea. We used stock prices of 12 tourism business-related companies listed on the Korean Stock Exchange. The focus was specifically macro-economic variables such as the industrial production index, the exchange rate, and interest rates of CD throughout the period of January 2003 to December 2016 and these factors were used for the empirical analysis. We employed a panel unit root test and a panel co-integration test. The panel Granger causality test based on a panel VAR (vector autoregressive) model because panel data estimation procedures offer more robust estimates by utilizing variations between individual stocks as well as demonstrating variations over time. We also employed an estimate panel regression model with a fixed effect. The results prove that all macro-economic variables including exchange rates, the industrial production index and CD interest rates all influence stock prices of tourism business-related companies. This is proven according to both a panel Granger causality test and a panel regression analysis used throughout this research. The results are evidence that macroeconomic variables contain significant information that can help forecast stock prices of tourism business-related companies. To our knowledge, this study is one of the first to examine the relationship between stock prices of tourism business-related companies and macro-economic variables throughout Korea that employed panel VAR model and panel regression model.
El papel de la participación ciudadana en las políticas públicas urbanas, bajo el actual escenario de la gobernanza
Authors: Castillo Cubillos Monica
Published: November 2017

The transformation of the state is imminent, this is because other factors, that under the current situation of governance there is not an strategic actor in the new global order, that can manage the monopoly of knowledge, experience and resources needed to solve the problems and get new  efficiently, opportunities. Therefore, must devise and reinvent new forms of governance in the company of other strategic actors, one of these actors is citizenship. In this regard, we must ask, what is the role of citizen participation?It is necessary to involve thinking about public policy, as one of the roles in which citizens may or may not make such effective participation. Taking into account, that public policy instruments can encourage and strengthen governance, in scenarios where there is a real participation of citizens. Let us see how true this is.