bluuebunny/crossref_metadata_2025 huggingface dataset:
Participação e Confiança na Comunicação Comunitária: Os Casos do Vela Notícias e do Jornal da Aldeia
Authors: Gonçalves Adriana , Grupillo Aline , Victor Melo Paulo
Published: March 2024

Esta pesquisa tem como objetivo compreender as dinâmicas de participação presentes em veículos informativos produzidos por cidadãos não-jornalistas, no interior de Portugal. A partir de um estudo exploratório, são analisadas duas iniciativas desenvolvidas por comunidades localizadas no interior do país, o Vela Notícias, na região Centro, e o Jornal da Aldeia, na região do Alentejo. Estas são entendidas como objetos empíricos de um fenómeno que reflete o distanciamento e os constrangimentos dos média tradicionais, o desejo das populações destes territórios de partilharem conhecimento de interesse local e a necessidade de os cidadãos se sentirem representados social e culturalmente. As duas iniciativas surgiram em regiões desertificadas, com menos de 1.000 habitantes, e envelhecidas, segundo os Censos 2021 (Instituto Nacional de Estatística, 2021).A fim de compreender e discutir tais questões, além da revisão da literatura pertinente ao tema, realizaram-se entrevistas semiestruturadas, como procedimento metodológico, aos participantes envolvidos na produção informativa dos dois média comunitários. A importância do estudo consiste em compreender dinâmicas comunicacionais de proximidade que envolvem cidadãos não-jornalistas.Os cidadãos das duas freguesias participam na criação de conteúdos, na escolha dos assuntos, na edição e na distribuição dos periódicos. A produção não está submetida às lógicas de seleção, filtragem e hierarquização jornalísticas. Ainda assim, os entrevistados demonstram interesse e confiança nas informações publicadas. O interesse em participar relaciona-se com o desejo de partilha de valores comuns e vínculos culturais, que contam ainda com o sentimento de pertença e de responsabilidade social.
SPECIFICITY OF PRODUCTION AND USAGE OF BIG DATA IN PUBLIC ADMINISTRATION
Authors:   Lomonosov Moscow State University, Shevtsova Inessa , Dneprovskaya Natalia ,   National Research University Higher School of Economics; Financial University under the Government of Russian Federation
Published: March 2024

Differences in the practice of Big Data (BD) usage between the private and public sectors are causing a problem of public administration access to advanced BD technologies and methods used in business. The high potential of BD is in demand by public organizations while private businesses hold these technologies and methods. The study of barriers to the dissemination of a practice of BD usage in public administration allows identification of possibilities and directions for BD production and use by public organizations. Russian and foreign cases of production and incorporation of BD in public administration for their analysis were selected from scientific and business sources. The barriers limiting work with BD in public administration are identified: a legal regulation of BD implementation, the structure and functioning of the IT infrastructure of public administration, requirements for the quality of data as content, and the scope and scale of socio-political development problems in public administration. Analysis of BD application in public administration has shown the ways of BD production, such as signal reception and date entry, as well as the necessity of using the IT infrastructure of business. Ways of implementing BD vary due to their multitasking in the public and private sectors. Since BD accumulated by public organizations is in demand by private businesses, providing a data access mechanism can be an approach to enhancing the digital economy at the local and state levels. The study demonstrates the high importance of finding the ways to develop and disseminate BD for public authorities.
THE MANAGEMENT OF GREENING SOCIETIES USING PRACTICE THEORIES
Authors:   Tyumen State University, Zakharova Olga , Zherebyateva Natalia ,   Tyumen State University
Published: March 2024

To assess the effectiveness of managing the impact of society on the environment, politicians and researchers use modeling of socio-economic processes with regard to environmental challenges and effects. The current paper explores the “pressure-state-response” model (PSR): human activity impacts the natural environment (pressure) and affects its quality and quantity of natural resources (state); society responds to these changes through policies as well as through changes in consciousness and behavior (response). Based on the theories of practice, we considered the element of “pressure” that shows the anthropogenic impact on the natural environment as a set of social practices, by changing the elements of which we can effectively manage the current state and possible responses. As a result, we selected the ideas that may help overcome the limitations of the “pressure-state-response” model. Besides, we described social practices as an element of “pressure”, focusing on the connections of social practices with the elements of “state” and “response” to explain how social meanings, competencies, and infrastructure determine the use of natural resources and how the anthropogenic impact on the natural environment should be reduced. We also identified possible approaches to developing indicators that characterize the components of the “pressure-state-response” model. The article may be of interest to researchers studying the processes of greening, scientists using the “pressure-state-response” model, and authorities developing more effective responses to the degradation of the natural environment.
Atherosclerosis and wine
Authors: Bozidar Kocmur
Published: March 2024

One of the most important risk factors for the origin and development of atherosclerosis is certainly excessive intake of fat in everyday nutrition. This risk factor, and the way it affects the origin and development of atherosclerosis, is described in the article “Atherosclerosis and lymph/risk factors”. In this article, based on verified and proven facts, it is suggested that the primary causes and initiators of atherosclerotic changes in the arterial system of the circulatory system are chylomicrons, especially large ones, which occur under the influence of several risk factors.
Hedging policy using neural networks and its combination with heuristic algorithms case study: Dez Reservoir
Authors: Farzane Karami
Published: March 2024

In recent years, the use of various Artificial Intelligence (AI) methods, such as evolutionary computation, heuristic algorithms, artificial neural networks, and fuzzy theory calculations, has gained popularity in addressing water resources issues. These algorithms have shown great success in solving problems that traditional deterministic methods struggle with. This study focuses on optimizing Dez reservoir operation over a long-term period using a nonlinear loss function through an evolutionary artificial neural network algorithm. The outcomes of this approach are then contrasted with genetic exploration and harmony search algorithms, highlighting the strengths and weaknesses of each method. Ultimately, a combination of the evolutionary artificial neural network method and hedging models is employed for optimal reservoir management, with results compared to the previous approach. Results show the appropriate performance of combining hedging policy with artificial neural network and harmony search algorithm. This combination significantly reduces the vulnerability value with a slight decrease in reliability.
Cas9-targeted Nanopore sequencing (CANS) v1
Authors: Merkulov Pavel , Kirov Ilya
Published: March 2024

Here we provide a protocol for Cas9-targeted Nanopore sequencing. We successfully applied this method for targeted sequencing and DNA methylation profiling of genes in cereal genomes, as well as for insertions of transposable elements (inherited and somatic) in Arabidopsis.
Populating NCBI template for submissions using BioNumerics v2
Authors: Timme Ruth , Balkey Maria , Haendiges Julie , Sauders Brian , Lusk Pfefer Tina
Published: March 2024

PURPOSE: to define the standard operating procedure for collecting isolate metadata using BioNumerics for submission of food/environmental isolates to NCBI. SCOPE: to provide a standardized procedure to collect isolate metadata using BioNumerics for submission of food/environmental isolates to NCBI. RESPONSIBILITIES- SOP Responsible Officials: Ruth Timme, Maria Balkey The GenomeTrakr Network Management will be responsible to monitor GenomeTrakr submissions processed through Bionumerics and ensure that all GT labs are familiar with the mandatory metadata fields required for submission of GenomeTrakr sequencing records to NCBI. V3: Dropdown menus from controlled vocabulary added to the ncbi_update submission sheet
IMMUNOFLUORESENCE ANTIBODY (IF) STAINING PROTOCOL v1
Authors: Vermilyea Scott
Published: March 2024

This is the basic protocol for antibody staining of formalin fixed paraffin embedded (FFPE) tissue.
Populating NCBI template for submissions using BioNumerics v7.6 v2
Authors: Timme Ruth , Balkey Maria , Haendiges Julie
Published: March 2024

PURPOSE: to define the standard operating procedure for collecting isolate metadata using BioNumerics for submission of food/environmental isolates to NCBI. SCOPE: to provide a standardized procedure to collect isolate metadata using BioNumerics for submission of food/environmental isolates to NCBI. RESPONSIBILITIES- SOP Responsible Officials: Ruth Timme, Maria Balkey The GenomeTrakr Network Management will be responsible to monitor GenomeTrakr submissions processed through Bionumerics and ensure that all GT labs are familiar with the mandatory metadata fields required for submission of GenomeTrakr sequencing records to NCBI. V3: Dropdown menus from controlled vocabulary added to the ncbi_update submission sheet
GENERATION OF RECOMBINANT αS AND PFF PROTOCOL v1
Authors: Vermilyea Scott
Published: March 2024

This is a collection of protocols including recombinant αS purification and αS PFF assembly.
Protein Lysate Preparation Protocol (Culture) v1
Authors: Vermilyea Scott
Published: March 2024

This protocol details about the protein lysate of the culture.
Inducing Plasmolysis in Root Hair Cell Membranes: A Sensitive Assay for Studying Cell Membrane Physiology v1
Authors: Michel Lecona Jiménez Antonino , Arthikala Manoj-Kumar , Nanjareddy Kalpana
Published: March 2024

Plasmolysis, a fundamental phenomenon in plant physiology, occurs when plant cells are exposed to a hypertonic extracellular medium, resulting in the loss of water and shrinkage of the cell contents. This process highlights the semipermeability of plant cell membranes, leading to the separation of the plasma membrane from the cell wall. The unique characteristics of plasmolysis make it a valuable tool for studying various aspects of cell membrane physiology. The protocol outlined in this article focuses on inducing plasmolysis, specifically in root hairy cell membranes. Root hairs, being highly specialized structures involved in nutrient uptake and interaction with the surrounding soil environment, provide an ideal model system for studying membrane physiology. Plasmolysis offers researchers a controlled environment to observe and analyze various molecular and phenotypic characteristics of the plasma membrane. By inducing plasmolysis, researchers can investigate changes in membrane integrity, permeability, and functionality under different experimental conditions. Additionally, plasmolysis can facilitate the study of cellular responses to osmotic stress, providing insights into plant adaptation mechanisms. This protocol provides a step-by-step guide to efficiently obtaining protoplasts from plant root cells undergoing plasmolysis. Protoplasts, or plant cells with their cell walls removed, offer a simplified system for studying membrane properties and dynamics. The simplicity and cost-effectiveness of the method make it accessible to a wide range of researchers interested in membrane physiology studies. The protocol presented here offers a valuable tool for researchers interested in investigating the intricate mechanisms underlying plant cell membrane physiology. By inducing plasmolysis in root hairy cell membranes and obtaining protoplasts, researchers can delve deeper into understanding the fundamental processes governing plant cell biology and adaptation to environmental cues.
KUR’AN’A GÖRE KÂMİL İMAN YOLUNDA AKIL VE KALP UYUMUNUN TEMEL NİTELİKLERİ
Authors: ALPTEKİN Zeynel Abidin
Published: March 2024

Bu araştırmada Kur’an’da akıl ve kalp ilişkilerinin mahiyeti ve kâmil bir Mü’min olma yolunda bu iki kurucu unsurun kuşandıkları asli roller incelenmiş ve hayati önemi sahip bu iki kabiliyeti kâmil Mü’min olma sürecinde ilişki boyutları ve metafizik âlemle bağlantı düzeyleri incelenmiştir. Çalışma Kur’an metni merkezli nitel araştırma yöntemiyle ele alınmıştır. Araştırmada başvurulan kaynadıkları doküman analizi metoduyla sistematik bir şekilde taranmış ve elde edilen veriler alanın temel ilke ve esasları çerçevesinde değerlendirilmiştir. Akıl ve kalp ilişkileri mevzusu araştırılırken öncelikle ilk dönem İslâmî kaynaklara müracaat edilmiş, ikinci aşamada güncel çalışmalara başvurulmuştur. Bu kapsamda kadim ve güncel kaynaklardan yola çıkılarak Kur’an ayetleri merkezli inceleme yöntemi takip edilmiştir. İnsanı diğer varlıklardan üstün kılan akıl yeteneğinin kalbin uhdesinde yer alıp almadığı ve iman-küfür iradesini belirleme hususunda akıl ve kalbin rolleri çalışmanın ana temasını teşkil etmiştir. İnsanı diğer varlıklardan üstün kılan unsur, akıl sahibi oluşunda saklıdır. Beşer akıl ve irade sahibi oluşu dolayısıyla söz ve eylemlerinden sorumlu tutulacaktır. Akıl, bilme, anlama, kavrama ve muhakeme kurma aracıdır. Bu üstün kabiliyet duyular aracılığıyla elde ettiği bilgileri toplayıp sentezlemektedir. Temel bilgi edinme araçları vasıtasıyla tedarik edilen ilmi veriler, temel anlama ve muhakeme makamı kalp süzgecinden geçirilerek idrak edilmektedir. Yaygın şekilde bilinenin aksine Kur’an, kalbin asıl anlama ve kavrama mercii olduğunu belirtir. İslam ulemasının çoğunluğuna göre kalbin anlama işlevi, uhdesinde yer alan yardımcı bir kuvvet tarafından sağlanmaktadır ya da aklı bilme ve anlama fonksiyonlarını icra etmek üzere yönlendirmektedir. Akıl maddi âlemdeki bilgileri konu edinirken, kalp gaybî âleme ait unsurlarla ilgilenmektedir. İnsanın ebedi saadet ve kurtuluşu Allah’a iman etmesine bağlıdır. İman, kalpte tecelli etmektedir. Kalp, insan devletinin başkenti konumundadır. Kalp, işlenen gayr-ı ahlaki fiiller sonucu kararıp mühürlenmekte ve manen işlevsiz hale gelmektedir. Olumlu ve doğru davranışlar ise sahibinin kalbini hak ve hakikat mesajlarını işitecek donanıma sahip kılmaktadır. Aksi istikametteki tavır ve davranışlar ise sahibini inkâra yönlendirmektedir.
Comparative evaluation of the perioperative anesthesia methods for cancer patients undergoing pancreaticoduodenectomy
Authors: Zakharenkova Iuliia S. , Khoronenko Victoria E. , Trifanov Vladimir S.
Published: March 2024

BACKGROUND: Pancreatoduodenal resections are one of the most traumatic and technically complex interventions in abdominal surgery. The correct anesthetic management and pain relief allow to substantially reduce the risk of perioperative complications, which remains high even in high-volume oncology centers with extensive experience. Finding new components and methods of anesthesia combined with evaluation of their effectiveness and safety remains a pressing issue.
AIM: To evaluate the efficacy and safety of using intravenous lidocaine infusion as a component of anesthesia and postoperative analgesia in cancer patients during pancreatoduodenal resection.
MATERIALS AND METHODS: We analyzed the course of anesthesia, operation and postoperative period of 43 patients (mean age 63.2±7.1 years) undergoing pancreaticoduodenectomy. For the purposes of the study, patients were randomly divided into 2 groups, based on anesthesia method: for the first group (n=19) we used epidural analgesia as a component of perioperative anesthesia, for the second group (n=24) we used prolonged intravenous infusion of lidocaine at an average dose of 1 mg/(kg×h). We analyzed the severity of pain syndrome according to Numeric rating scale for pain in postoperative period, as well as opioid requirement, the time of gastrointestinal function recovery, and post-operative complications frequency. In order to prevent systemic toxicity, drug monitoring was carried out — the determination of the plasma concentration of lidocaine.
RESULTS: Perioperative opioid requirement was comparable between groups, with no statistically significant differences observed. The degree of pain syndrome according to the Numeric rating scale for pain did not differ statistically, except for the number of points during activation on day 3: 4.00 (95% confidence interval 3.49–4.51) for epidural analgesia group, compared to 3.12 (95% confidence interval 2.64–3.61) for lidocaine infusion group, p=0.014. There was also a statistically significant increase in infusion volume for epidural analgesia group compared to lidocaine infusion group [8.83 ml/(kg×h) (Q1=7.90; Q3=10.06) and 7.33 ml/(kg×h) (Q1=6.28–Q3=8.49) respectively, p=0.034], as well as a greater need for intraoperative vasopressor support among the patients [15 (78.9%) and 10 (43.5%) respectively, p=0.029]. In the lidocaine group, the time to onset of peristalsis was significantly shorter than in the epidural analgesia group [median 48.0 h (Q1=48.00; Q3=72.00) compared to median 60.0 h (Q1=36.00; Q3=64.50) respectively, p=0.042]. The frequency of postoperative complications did not differ between the groups.
CONCLUSION: Based on a comparative analysis of the study results, it can be concluded that prolonged intravenous infusion of lidocaine, as a component of perioperative anesthetic protection during pancreatoduodenal resections, is safe and comparable in terms of analgesic efficacy to epidural blockade.
Immunophenotype of dendritic cell differentiation markers in breast cancer in in-vitro conditions
Authors: Golderova Aytalina S. , Nikolaeva Irina E. , Troev Ivan P. , Zharnikova Tatiana N. , Nikiforov Petr V.
Published: March 2024

BACKGROUND: During maturation, dendritic cells begin to synthesize peptides that include the major histocompatibility complex MHC-II molecules, costimulatory molecules CD40+, CD80+, and CD86+, as well as CD83+ proteins. In cancer patients, dendritic cells dysfunction can lead to serious consequences in the form of deficiency of antitumor immunity, tumor progression, and decreased response to immunotherapy. All this is important to take into account to rethink the tumor immunotherapy strategy. Thus, approaches aimed at enhancing the viability of dendritic cells and preventing their dysfunction and polarization should be considered as a necessary step in order to increase the effectiveness of dendritic cell vaccines.
AIM: To evaluate the expression characteristics of differentiation markers of dendritic cell maturation obtained from peripheral blood monocytes under culture conditions in patients with breast cancer.
MATERIALS AND METHODS: With informed voluntary consent, 19 patients diagnosed with breast cancer were examined. Mononuclear cells were isolated on a Ficoll density gradient. For adhesion of monocytes to the bottom of 75 cm2 culture flasks, they were pre-incubated for 1.5 hours in conditions of 5% CO2 at 37 ℃. Growth and differentiation factors — GM-CSF (40 µl) and IL-٤ (٤٠ µl) — were added to the attached monocytes on the 1st, 3rd and 5th days of cultivation. Immunophenotyping of dendritic cells was carried out on days 7 and 9 of cultivation using flow cytometry.
RESULTS: Flow cytometry data indicate that the viability of cultured dendritic cells in cancer patients is significantly reduced on day 9 compared to day 7 of cultivation. On day 9, there was a significant increase in CD80+ expression (2.40, p=0.028) and a decrease in CD83+ (1.65, p=0.036) compared to day 7.
CONCLUSION: In general, significant signs of maturation were observed: loss of the monocyte marker CD14+, increased expression of CD80+, CD83+, CD86+ — the main markers. A decrease in CD83+ can be considered as a suppression of excessive activation of immune responses. In the future, a more in-depth study of the characteristics of maturation and activation of cultured dendritic cells is necessary to understand the mechanisms and factors influencing the decrease in the effectiveness of immunotherapy with an autologous dendritic cell vaccine.
Absence Justified? On Several Themes Absent from the Exhibition Ukraine. A Different Angle on Neighbourhood
Authors: Dębicki Marcin
Published: March 2024

The aim of this article is to analyse the content of the exhibition Ukraine. A different angle on neighbourhood, presented in Cracow from September 2021 to January 2022, aimed at identifying exemplary themes that would have significantly enriched the educational and informational dimension of this exhibition, but for various reasons did not make it into it. Exemplary absences included the regional differentiation of Ukraine, the historical-independence status of Galicia, the demographic decline of Poland’s neighbours from across the river Bug, the importance of the Cossacks in the context of the 17th-century problems of the Polish-Lithuanian Commonwealth and the place of the “Vistula” action in the consciousness of Poles. A separate point is devoted to the absence of the motif of the Ukrainian Insurgent Army (UPA) and the Volhynian massacre from the exhibition, indicating – also through references to the declarations of people involved in the creation of the exhibition – why this motif was to be expected, and proposing a way in which this motif could have been creatively presented. Although the essence of the considerations is to indicate points which would enrich the school knowledge of the primarily Polish audience of the exhibition in relation to the framework of Ukrainian identity (identities) and the Polish-Ukrainian neighbourhood, in its essence the article does not prejudge the necessity to take up the aforementioned motifs, nor does it constitute a closed list of topoi which would be crucial in determining such a framework.
Management of midline diastema using the direct composite resin technique - A case report
Authors: Kishore M , Gayathri M , Bari L Md. Wasim , Yadav M Sreeja , Lakshmi K Prathibha
Published: March 2024

Diastema or space between the anterior teeth is a common aesthetic complaint of patients. Direct composite resins in midline diastema cases allow dentists to have complete control in formation of natural smiles. This case report describes midline diastema closure with esthetic composite layering technique. A 25-year-old male patient reported to the clinic, with a complaint of spacing in the upper front tooth region of the jaw. The direct aesthetic composite laminate veneer was considered as the treatment of choice for the build-up of both maxillary central incisors as a more conservative, inexpensive, aesthetic, and quicker option. A2 & A3 shades were selected; prepared tooth surface was etched for 15 seconds using 37% phosphoric acid, rinsed with water for 20 seconds, and air dried with slight air pressure. Bonding agent was applied (Adper single Bond, 3M ESPE, USA) and cured for 20 seconds using (Vivadent Blue phase) curing light. The labial surface of the restoration was flattened using red banded knife-edge tip diamond bur. The natural look of the restored teeth was achieved after finishing and polishing. At six-month and one-year recalls the general outlook of the maxillary anterior teeth was considered natural and aesthetical. Clinically, both restorations have no fractures and also the restoration margins on both maxillary central incisors demonstrated no discolorations. By taking this into consideration and according to the positive results, an experienced dentist with proper case selection, using an appropriate technique and modern materials, can perform highly aesthetic and durable direct composite resin restorations that can satisfy patients as under the conditions of the case presented.
Control of the transcription of a foreign civil status document
Authors: Domański Adam
Published: March 2024

Celem artykułu jest wyjaśnienie problematyki kontroli transkrypcji zagranicznego dokumentu stanu cywilnego dokonywanej w formie czynności materialno-technicznej. W związku z tym autor postawił pytanie, czy dokonana transkrypcja zagranicznego dokumentu stanu cywilnego może podlegać kontroli w trybie skargi do sądu administracyjnego, określonej w art. 3 § 2 pkt 4 ustawy z dnia 30 sierpnia 2002 roku Prawo o postępowaniu przed sądami administracyjnymi (Dz.U. z 2022 r., poz. 329, 655, 1457, 1855), dalej: p.p.s.a. Odpowiadając na tak postawione pytanie, należało stwierdzić, że kontrola dokonanej transkrypcji nie następuje przez złożenie skargi do wojewódzkiego sądu administracyjnego określonej w art. 3 § 2 pkt 4 p.p.s.a., lecz ma charakter pośredni i jest dokonywana ze względu na rodzaj uchybień w postępowaniu w przedmiocie sprostowania, uzupełnienia, unieważnienia aktu stanu cywilnego, ewentualnie w sądowym postępowaniu nieprocesowym o ustalenie jego treści. Ze względu na mnogość i skomplikowanie sposobów tej kontroli warte rozważenia są zmiany legislacyjne, polegające na wprowadzeniu instytucji unieważnienia czynności materialno-technicznej z zakresu rejestracji stanu cywilnego decyzją kierownika USC. Autor przed omówieniem sposobów weryfikacji dokonanej transkrypcji, stanowiących główny temat rozważań, pochylił się także nad podmiotem uprawnionym do zainicjowania tejże kontroli. Ze względu na to, że w postępowaniu w przedmiocie transkrypcji zagranicznego dokumentu stanu cywilnego będzie nim zasadniczo podmiot wnoszący o umiejscowienie, szczegółowej stanu cywilnego (Dz.U. z 2022 r., poz. 1681), dalej: p.a.s.c., stanowiący, że wniosek do wybranego kierownika urzędu stanu cywilnego o dokonanie transkrypcji może złożyć osoba, której dotyczy zdarzenie podlegające transkrypcji, lub inna osoba wykazująca interes prawny w transkrypcji lub interes faktyczny w transkrypcji dokumentu potwierdzającego zgon. Pojęcie interesu prawnego i interesu faktycznego nie zostało zdefiniowane przez ustawodawcę, dlatego aby dokonać wykładni tych pojęć, autor sięgnął po dorobek przedstawicieli doktryny prawa administracyjnego, odwołujących się do koncepcji E. Bernatzika. W artykule główną metodą badawczą była metoda analityczno-prawna.
Advertising of Medicinal Products and Protection of Consumer Interest
Authors: Woźna-Burdziak Weronika
Published: March 2024

W niniejszym artykule poruszono problematykę reklamy produktów leczniczych w perspektywie ochrony interesu konsumenta. Jako problem badawczy artykułu obrano zrekonstruowanie normatywnego wzorca pośredniej ochrony konsumenta przed niezgodną z przepisami ustawy Prawo farmaceutyczne reklamą produktów leczniczych kierowaną do publicznej wiadomości. W pracy posłużono się metodą dogmatycznoprawną. Do rozwiązania postawionego problemu badawczego konieczne było przeprowadzenie analizy obowiązującego stanu prawnego z odwołaniem do doktryny i orzecznictwa. Wybrana metoda badawcza pozwoliła na udzielenie odpowiedzi na postawione w opracowaniu pytania dotyczące między innymi tego, czy obecna forma nadzoru nad reklamą produktów leczniczych (a ściślej: nadzoru nad legalnością reklamy produktów leczniczych) jest wystarczająca oraz czy pacjent/konsument jest w sposób efektywny chroniony przed niezgodną z ustawą Prawo Farmaceutyczne reklamą produktów leczniczych kierowaną do publicznej wiadomości. W wyniku przeprowadzonych badań stwierdzono, że obecnie obowiązujące regulacje dotyczące nadzoru nad reklamą produktów leczniczych kierowaną do publicznej wiadomości nie są wystarczająco skuteczne, bowiem nie chronią w sposób dostateczny interesu konsumenta. Powyższe pozwoliło na zaproponowanie zmian w obowiązujących w przepisach w postaci wprowadzenia kontroli ex ante reklam produktów leczniczych kierowanych do publicznej wiadomości.
Pathogenesis of EMA negative PR negative Microcystic Meningioma: A Case Report
Authors:   Pathologist, Department of Pathology, RML Mehrotra Pathology Pvt. Ltd, Nirala Nagar, Lucknow, Uttar Pradesh, India, Mehrotra Supriya
Published: March 2024

A patient, aged 35 years female complained of headache. CT examination revealed a non-succable tumor at anterolateral aspect of dura. Tumor extended from the right cervicomedullary junction upto C7 level. Tumor was excised and multiple soft tissue pieces, together measuring 1.5×1×1 cm were cellected. All the pieces were sectioned. Tumor had a sieve-like and cyst-like appearance. Section showed a circumscribed globular tumor which consisted of proliferated bland spindle cells. Tumor had an edematous stroma and presented a microcystic appearance. The cells had elongated ovoid nuclei and mild eosinophilic cytoplasm. Several thin-walled vascular spaces were also seen in the tumor. Strong positive reaction was obtained with an anti-S100 antibody, suggesting a neural origin of tumor cells. Further, anti-Ki 67 antibody gave mild reaction (Ki67 index was 12%) suggesting benign neoplasm. Anti-CD 34 and anti-D2.40antibodies gave positive reactions (2+) with small blood vessels of the tumor. Keywords: Benign cystic neoplasm with similar behavior among various subtypes.
Evolution of Radiotherapy- A Brief Review
Authors:   Department of Radiation Oncology, All India Institute of Medical Sciences Guwahati, Changsari, Assam-781101, India, Lahkar Dhanjit
Published: March 2024

Beginning with the discovery of X-rays by Wilhelm Conrad Röntgen in 1895 and the subsequent application of X-rays for cancer treatment in 1896, the narrative unfolds through the advancements in radiation therapy modalities. The discussion covers External Beam Radiotherapy (EBRT), including various techniques like 3D-CRT, IMRT, IGRT, stereotactic radiotherapy, and proton therapy. Emerging technologies such as Tomotherapy, Stereotactic Radiosurgery (SRS), Boron Neutron Capture Therapy (BNCT), Carbon Ion Therapy, and Brachytherapy are explored, offering tailored approaches for different cancer types. The article delves into the history and advancements of brachytherapy, highlighting its techniques like intracavitary, interstitial, and HDR surface mould brachytherapy. The continuous pursuit of precision, efficacy, and reduced side effects in cancer treatment is evident throughout the narrative. The article emphasizes the crucial role of radiation therapy, employing various ionizing radiation types, in targeting and eradicating cancer cells while minimizing harm to normal cells. The ongoing quest for advancements in technology and techniques reflects the commitment to improving cancer treatment outcomes. This article provides a comprehensive overview of radiation therapy's historical evolution and current state in cancer treatment Keywords: Radiotherapy, EBRT, Brachytherapy, IMRT, SRS, IGRT, Proton therapy
MICROBIOTA INTESTINAL E ESQUIZOFRENIA: ALTERAÇÕES, TRATAMENTO E INTERFERÊNCIAS ALIMENTARES.
Authors: Damázio Louyse Sulzbach , Ioppi Zugno Alexandra
Published: March 2024

A esquizofrenia é uma doença neuropsiquiátrica crônica e severa. A microbiota intestinal é essencial para o desenvolvimento e amadurecimento de sistemas cerebrais associados à respostas ao estresse e parece estar alterada nesta condição psiquiátrica.  Este trabalho se trata de uma revisão de literatura que foca na influência da alteração da microbiota em esquizofrênicos, bem como no tratamento com probióticos e sensibilidades alimentares que alteram a flora intestinal. Pacientes com esquizofrenia possuem diversidade dos filos e gêneros de bactérias quando comparado a indivíduos controles. Também apresentam um aumento da translocação bacteriana e anticorpos anti-gliadina e anti-caseína. Sugere-se melhora dos sintomas e de marcadores bioquímicos após o tratamento com probióticos. Na sua fisiopatologia, a esquizofrenia apresenta reações auto-imunes, de sensibilidades alimentares e inflamatória, podendo alterar as composições microbianas no intestino.
A influência da alimentação na prevenção do câncer colorretal: uma revisão bibliográfica.
Authors: Zanette Netto Maiara , De Oliveira Marques Schérolin
Published: March 2024

O câncer colorretal representa a neoplasia mais comum do trato gastrointestinal. É um dos cânceres mais comumente diagnosticados e a terceira causa de morte relacionada ao câncer no mundo. O CCR é caracterizado por fatores hereditários e esporádicos (consumo de álcool, alta ingestão de gordura, alimentos ricos em calorias, alimentos processados e ultraprocessados, obesidade, tabagismo e sedentarismo). Vários fatores de risco podem colaborar para o aparecimento dessa neoplasia, entretanto a alimentação parece ser o fator que contribui mais para o desenvolvimento do CCR e é capaz de alterar a microbiota intestinal. Assim, o objetivo desse estudo foi realizar uma revisão bibliográfica com a finalidade de analisar a influência da alimentação na prevenção do câncer colorretal. Para tal, buscou-se artigos originais e de revisão de diversos autores. O consumo de carne vermelha, alimentos processados e ultraprocessados, ingestão de alimentos gordurosos e ricos em calorias auxiliam no desenvolvimento do CCR. No entanto, o alto consumo de alimentos funcionais como frutas, vegetais, fibras, gorduras boas, probióticos e prebióticos ajudam na prevenção da neoplasia. Por fim, buscar uma alimentação saudável poderá modular a microbiota intestinal e prevenir o surgimento do câncer colorretal.              

                                                   

Palavras-chave: Alimentação; Câncer Colorretal; Dieta; Nutrição.
Síndrome de Franceschetti-Klein: Achados de imagem
Authors: De Aguiar da Costa Maiara , Brunel Alves Anita , Burato Wessler Leticia , Lin Jaime , Ludvig Gonçalves Cinara
Published: March 2024

A síndrome de Franceschetti-Klein (SFK) teve somente em 1900 as suas principais características descritas por E. Treacher-Collins. E uma doença autossômica dominante rara que compromete o desenvolvimento craniofacial e apresenta uma incidência de cerca de 1 caso para cada 50.000 nascidos vivos. São consideradas características obrigatórias: fissuras palpebrais oblíquas em posição antimongolóide; anomalias da pálpebra inferior com a presença de colobomas ou alterações nos cílios; hipoplasia da maxila e mandíbula. Este estudo teve como objetivo descrever todas as características clínicas da SFK através de imagens para facilitar o pronto reconhecimento da síndrome. Apresentamos um relato de caso de um paciente de seis anos com todas as características clínicas da síndrome de Franceschetti-Klein. Ainda que as manifestações clínicas sejam típicas, a presença de todos os achados não é rara e a descrição escrita e ilustrativa favorece o pronto reconhecimento da síndrome.

Palavras-chave: Ossos da face, Coloboma, Disostose Mandibulofacial, Doenças Otorrinolaringológicas.
Gerenciamento de Projetos na gestão em saúde
Authors: Da Silva Pinto Jonata , Tessmann Mágada , Lux Eduardo , Gonçalves Zilli Marlon
Published: March 2024

À proporção que as empresas se tornam mais dependentes da tecnologia, o gerenciamento de projetos efetivo se torna mais relevante. O objetivo deste trabalho foi identificar as práticas da metodologia de gerenciamento de projetos Kanban em serviços de saúde. Foi utilizada a pesquisa qualitativa, descritiva, do tipo revisão integrativa, seguindo os passos propostos por Vargas Delgado et al (2020), na base de dados acadêmica Scopus, devido ao seu caráter multidisciplinar. Como resultados, identificou-se que os trabalhos abordam dois principais benefícios: melhora na rotatividade de leitos e melhora na gestão de cadeia de suprimentos de serviços de saúde. O primeiro ocorre porque há um maior controle e visualização da ocupação de leitos e, portanto, isso permite maior disponibilidade; redução do tempo de permanência nas internações; maiores índices de alta hospitalar; redução de custos; menor quantidade de óbitos e de transferências para outro setor. O segundo implica a otimização do trabalho de enfermagem, o armazenamento mais organizado, menos espaço necessário para armazenamento, menos itens vencidos, aumento da satisfação do cliente interno e incorporação da maioria dos produtos no sistema.
Designing a Framework for Assessing Agripreneurship Action for the Green Scheme Irrigation Projects, Namibia
Authors: Neema Michael
Published: March 2024

The main aim of this paper is to develop a framework aimed at assessing the agricultural entrepreneurship action for the Namibian Green Scheme Irrigation Projects (GSIP). The paper examine the factors affecting the entrepreneurship action of small-scale irrigation farmers (SSIF) at the Etunda GSIP. The paper used a quantitative research approach to yield descriptive and inferential statistics of the agricultural entrepreneurs’ perspective concerning their operations experiences at the GSIP. The study used Microsoft Office Excel 2019 analytical tool pack to analyse the data. The key findings revealed that all the SSIF operating at the Etunda GSIP are not only affected by individual factors but also by policy environment, finance, business support services, market environment, infrastructure as well as ecological factors. This paper addresses specifically one of the Namibian GSIP whereby it only adopted the perspective of SSIF. The study presents a framework that praises sectoral stakeholder connections that would help improve not only the GSIP performance but also the overall performance of the Namibian agricultural sector. The paper offers policymakers and practitioners a blueprint for developing entrepreneurship in an agricultural sector, especially around the Namibian GSIP.
Kajian Efektifitas Bacillus Sp dengan Penambahan Pupuk Kompos dalam Mengendalikan Busuk Hitam (Xanthomonas Campestris) pada Tanaman Kubis Bunga
Authors: Muslimah Syafira Ayu , Masnilah Rachmi
Published: March 2024

Produksi kubis bunga di Kabupaten Lumajang, Provinsi Jawa Timur pada tahun 2016 ke 2017 terjadi penurunan, hal ini disebabkan adanya beberapa faktor yang mempengaruhi produksi kubis bunga dari kualitas maupun kuantitas. Salah satu faktor yang menentukan keberhasilan produksi kubis bunga adalah serangan penyakit pada tanaman. Penyakit yang menyerang tanaman kubis bunga yaitu busuk hitam (Xanthomonas campestris) yang merusak sayuran terutama famili Brassicaceae. Pengendalian penyakit menggunakan pestisida kimia dapat menimbulkan dampak negatif bagi ekosistem dan kehidupan manusia. Cara efektif pengendalian serangan penyakit dapat melalui pemanfaatan agen hayati. Strategi pengendalian yang banyak dikembangkan yaitu pengendalian yang mengarah pada pemanfaatan potensi mikroorganisme. Salah satu agen pengendali hayati yang berguna bagi tanaman yaitu Bacillus sp. pengendalian penyakit dengan menambahakan pupuk kompos sebagai bahan pembawa dan menguntungkan antara tanaman dengan mikroorganisme. Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) dengan 5 perlakuan, yaitu P0: kontrol, P1: Bacillus sp., P2: Bacillus sp. + Pupuk kompos, P3: Bacillus sp + Pupuk vermikompos, P4: Bacillus sp. + Pupuk Bokashi. Setiap perlakuan diulang sebanyak 3 kali serta uji lanjut Duncan Multiple Range Test (DMRT). Variabel pengamatan meliputi masa inkubasi, keparahan penyakit, laju infeksi, populasi Bacillus sp. Hasil penelitian menunjukkan bahwa perlakuan Bacillus sp. dengan penambahan pupuk vermikompos merupakan perlakuan terbaik dalam menekan perkembangan penyakit, meningkatkan populasi Bacillus sp. dan jumlah daun tanaman dengan masa inkubasi 12 HSI, keparahan penyakit 23,44%, laju infeksi 0,067 unit/hari, efektifitas 72,30%, populasi Bacillus sp. 1,92x109 cfu/ml, dan jumlah daun tanaman 23 daun.
Pengaruh Penyemprotan Monokalium Fosfat dan Pemangkasan Pucuk terhadap Pertumbuhan dan Hasil Produksi Tanaman Cabai Rawit (Capsicum frustescens L.) pada Hidroponik Sistem Dutch Bucket
Authors: Setyadi Farhad Dwi , Fanata Wahyu Indra Duwi
Published: March 2024

Cayenne pepper plant (Capsicum frustences L.) is a plant that is synonymous with its spicy taste, so consumption needs are increasing. However, production of cayenne pepper plants has decreased due to a decrease in land conversion and climate influences. Application of hydroponic dutch bucket system and monopotassium phosphate (MKP) spraying as well as shoot pruning techniques at certain times to increase production. This research aims to determine the effect of MKP spraying and shoot pruning on the growth and production of cayenne pepper plants using the dutch bucket hydroponic system. The experimental design used two factorsthree test. The first factor is variation in concentration of MKP administration, with 3 levels. The second factor is the pruning time with 3 levels so that there are 27 experimental units. The data is then analyzed and evaluated using analysis of Variance (ANOVA). Each observed variable is analyzed separately and significant differences between average values are based on tests Duncan Multiple Range Test (DMRT) with a confidence level of 95%. The results show for the stem diameter variable, the monopotassium phosphate spraying treatment gave very significantly different results and shoot pruning gave significantly different results.The combination of monopotassium phosphate spraying treatment with a dose of 4 g/liter and a shoot pruning time of 21 days after planting (M3N2) gave the highest results for the variables of stem diameter, number of flowers to fruit, number of fruit, and fruit weight.
Organising Integration Support for Recent Immigrants in Sweden as a Spectacle: Practices and Consequences
Authors: Diedrich Andreas
Published: March 2024

This paper explores organising outside organisations in the context of the labour market integration of recent immigrants in Sweden. More specifically, it examines integration support events organised as a means of facilitating the efficient employment integration of recent immigrants. It draws on Guy Debord’s ideas of the spectacle in modern society and practice-based approaches to organising to explore how these events function as part of an integration spectacle as they produce and reproduce images of change and renewal where immigrants become employed and employers hire them, obscuring an otherwise sombre reality of inequalities. I use this lens to critically engage with field material collected as part of an ethnographically inspired field study of two annually held integration support events in Sweden, the Your Day! event and the Finally a Job! recruitment day, aimed at facilitating recent immigrants’ employment integration.
Time continuity and discontinuity in organizations. A reflexive case on Lecoquian pedagogy
Authors: Lasala Vito , Ripetta Silvio , Napolitano Domenico
Published: March 2024

For organization literature, time is a key concept in distinguishing improvisation from composition as organizational practices. In improvisation, generation and execution response(s) converge in time. In composition, these are disconnected and there’s a clear temporal separation between the creative process and its outcomes. From the emphasis on the time variable, this paper develops a study around continuity and discontinuity as a point of view onto organizational practices. First, it compares organization literature and performing arts literature, detecting in time continuity and discontinuity the constructs around which improvisation and composition can be defined. The paper then questions traditional assumptions of neatly separating improvisation and composition, exploring the issue of time continuity and discontinuity at the Ecole Lecoq, Paris for theatre. Drawing from empirical materials gathered through observational participation by one of the authors in this school’s activity, the article shows how improvisation and composition are intertwined, while continuity and temporal discontinuity continuously overlap. In light of this consideration, the paper argues that time management in organizations is affected by theoretical and practical understandings of time within artistic practices. Those practices, in fact, should not be considered as mere tools or metaphors for management, but as sources of organizational knowledge.
Gıda Atığı ve Şeker Fabrikası Atığı Kompostlarının Toprak Özellikleri ve Mısır (Zea mays L.) Bitkisinin Gelişimine Etkisi
Authors: Gürel Serhat
Published: March 2024

Bu çalışmada, gıda atığı kompostu (GAK), şeker fabrikası atığı kompostu (pancar tohumu atığı kompostu=PAK), çiftlik gübresi (ÇG) ve kimyasal gübrenin (NP) mısır bitkisinin büyümesi üzerindeki etkilerinin değerlendirilmesi amaçlanmıştır. Deneme, tesadüf parselleri deneme desenine göre sera koşullarında yürütülmüştür. Deneme; altı uygulama (gıda atığı kompostu, pancar tohumu atığı kompostu, ½ gıda atığı kompostu + ½ pancar tohumu atığı kompostu, çiftlik gübresi, 20 kg N da-1 için inorganik 20-20-0 NP gübresi ve kontrolü), üç farklı doz (1, 2, 4 ton da-1) ve üç tekrarlı olarak yürütülmüştür. Uygulamalar, kontrole göre tüm verim parametrelerini önemli ölçüde iyileştirmiştir. Toprak özellikleri ve besin elementleri konsantrasyonları 4 ton da-1 oranında kompost uygulaması ile diğer uygulamalara göre daha yüksek olmuştur. Genel olarak, ÇG ve NP uygulamaları bitki gelişim parametelerinde daha iyi sonuçlar vermiştir. ÇG ve NP, bitki besin elementi artışı sağlanması konusunda PAK uygulamaları ve GAK+PAK karışımlarından daha uygun materyaller oldukları belirlenmiştir. Fakat tüm parametreler birlikte değerlendiğildiğinde; GAK uygulaması ile toprak elektriksel iletkenliği (EC) ve topraktaki Na içeriğinin yükselmediği belirlenmiştir. Bununla birlikte bitkilerin hem makro hem de mikro element alımında dengeli bir materyal olduğu belirlenmiştir.
Rhynchosporium commune’ye Karşı Konukçu Dayanıklılığı
Authors: Yıldırım Şükriye , Çelik Oğuz Arzu
Published: March 2024

Rhynchosporium commune, arpa (Hordeum vulgare), diğer Hordeum türlerinde ve Bromus diandrus üzerinde yaprak lekesi hastalığına neden olan haploid bir fungustur. Dünya çapında tüm ılıman yetiştirme bölgelerinde bulunmakta ve ekonomik açıdan en önemli arpa patojenlerinden biri olarak kabul edilmektedir. Hastalığın kontrolünde en etkili ve sürdürülebilir yöntem dayanıklı çeşit kullanımıdır. Patojen ticari çeşitlerde kullanılan dayanıklılık genlerine karşı yeni virülent genotiplerini geliştirme yeteneğine sahiptir. Bu nedenle, markör destekli seleksiyon yolu ile farklı lokusların (niteliksel veya niceliksel) tanılanması ve piramitlenmesi dayanıklılık ıslahı açısından oldukça önemlidir. Bu derleme ile patojenin genetik varyasyonu, konukçu-patojen etkileşimi, dayanıklılıkta rol oynayan genler, yerel ve yabani çeşitlerde R. commune dayanıklılığı ve ülkemizde R.commune konukçu dayanıklılığı üzerine geçmişten günümüze yapılan çalışmalar özetlenmiştir.
Exploring inconsistencies in environmental impact assessments of organic farming
Authors: Komatsu Hikaru , Rappleye Jeremy
Published: March 2024

Despite the growing popularity of organic farming, persistent questions surround its environmental effects. A 2017 meta-analysis suggested elevated acidification and eutrophication potentials per unit of agricultural production for organic farming relative to conventional farming. However, a recent 2023 meta-analysis contradicted these findings. This brief communication article reveals that the disparities between these meta-analyses stem from differences in averaging methods and sample sizes. The 2023 meta-analysis, employing a more robust averaging method and a larger sample size, suggests that researchers should incorporate the 2023 findings into their investigations, potentially necessitating a reconsideration of agricultural policies and dietary choices to align with updated environmental impact assessments.