bluuebunny/crossref_metadata_2025 huggingface dataset:
Mammary Tumor Growth and Proliferation Are Dependent on Growth Hormone in Female SV40 C3(1) T-Antigen Mice
Authors: Unterberger Christopher J , McGregor Stephanie M , Kopchick John J , Swanson Steven M , Marker Paul C
Published: October 2022

Female SV40 C3(1) T-antigen (C3(1)/TAg) transgenic mice develop mammary tumors that are molecularly similar to human basal-like breast cancers with 100% incidence at 16 weeks of age. To determine the requirement for growth hormone (GH) signaling in these tumors, genetic crosses were used to create cohorts of female mice that were homozygous for a floxed growth hormone receptor (Ghr) gene and carried one copy each of the Rosa-Cre-ERT2 transgene and the C3(1)/TAg transgene (Ghrflox/flox; Rosa-Cre-ERT2; C3(1)/TAg+/0 mice). When the largest mammary tumor reached 200 mm3, mice were treated with tamoxifen to delete Ghr or with vehicle as a control. An additional group of Ghrflox/flox; C3(1)/TAg+/0 mice were also treated with tamoxifen when the largest mammary tumor reached 200 mm3 as a control for the effects of tamoxifen. After 3 weeks, tumors in mice in which Ghr was deleted began to shrink while vehicle and tamoxifen treatment control mouse tumors continued to grow. Pathological analysis of tumors revealed similar growth patterns and varying levels of necrosis throughout all groups. A decrease in cancer cell proliferation in Ghr-/- tumors relative to controls was observed as measured by Ki67 immunohistochemistry labeling index. These data suggest that even established C3(1)/TAg mammary tumors are dependent on the GH/IGF-1 axis.
Moving Beyond the Pandemic: Insights from a Shared Experience
Authors: Nathan Naveen
Published: October 2022

For over two years the resilience of humanity was tested with the coronavirus outbreak. At its outset the scientific community rallied and did its very best to disseminate accumulating knowledge in real time to contain the outbreak. Sobering lessons were learned in managing such a global crisis. Critical care anesthesiologists in particular were instrumental as decision makers and their insight is reflected in a review of how we may be better prepared in the future should another virus spread with such scale and severity. Members of the Society of Critical Care Anesthesiologists contribute to a special article in this issue that focuses on several broad themes that emerged from managing the pandemic. These include large scale decision making in health care systems, clinical management of a new disease, resource management with conversion of operating rooms to intensive care units, and health care provider well-being. These considerations are summarized in this infographic. It is heartening to see an article and an accompanying editorial in this issue that address what we have learned from our collective experience. It is a testament to the will of the scientific community and health care providers to evolve and overcome, to move beyond discouragement and prevail.
Self-organizing in vitro mouse neural tube organoids mimic embryonic development
Authors: Park JiSoo , Hsiung Hao-An , Khven Irina , La Manno Gioele , Lutolf Matthias P.
Published: October 2022

The embryonic neural tube is the origin of the entire adult nervous system, and disturbances in its development cause life-threatening birth defects. However, the study of mammalian neural tube development is limited by the lack of physiologically realistic three-dimensional (3D) in vitro models. Here, we report a self-organizing 3D neural tube organoid model derived from single mouse embryonic stem cells that exhibits an in vivo-like tissue architecture, cell type composition and anterior-posterior (AP) patterning. Moreover, maturation of the neural tube organoids showed the emergence of multipotent neural crest cells and mature neurons. Single-cell transcriptome analyses revealed the sequence of transcriptional events in the emergence of neural crest cells and neural differentiation. Thanks to the accessibility of this model, phagocytosis of migrating neural crest cells could be observed in real time for the first time in a mammalian model. We thus introduce a tractable in vitro model to study some of the key morphogenetic and cell type derivation events during early neural development.
Endurance training does not affect maximum exertion/distance capacity in Anolis carolinensis lizards
Authors: Sorlin Mahaut V. , Marks Jamie R. , Lailvaux Simon P.
Published: October 2022

Locomotor performance abilities are key predictors of survival and reproductive success in animals and understanding how selection targets them can provide insights into how morphology and physiology relate to fitness. But despite the large body of work on performance traits, along with well-established protocols to measure them, performance can be challenging to measure. Endurance, for instance, is commonly measured by recording how long an animal can run at a set pace until exhaustion, which is time consuming and requires dedicated equipment. Consequently, exertion or distance capacity, measured as distance run until exhaustion when chased, is often used as a proxy for endurance, but the relationship between these two metrics has never been assessed even though they likely rely on different underlying physiological mechanisms. We tested experimentally for a relationship between endurance and exertion by training green anole lizards for sprinting and endurance and measuring whether exertion capacity responds to either type of training. Prior to training and across treatments, males displayed a mean (±s.d.) exertion capacity of 14.08±0.29 m and females 12.03±3.52 m; after training, this was 14.78±3.57 m and 12.19±2.21 m, respectively. We found that exertion capacity was unaffected by either type of training in green anoles. We also show that a positive relationship between endurance and exertion capacity pre-training exists only in females and that this relationship is inconsistent among studies. Exertion should be studied as a locomotor trait in its own right and not as a proxy for endurance.
The role of ecdysteroid in the regulation of ovarian growth and oocyte maturation in Rhodnius prolixus, a vector of Chagas disease
Authors: Benrabaa Samiha A. M. , Orchard Ian , Lange Angela B.
Published: October 2022

Rhodnius prolixus is a blood-gorging insect that is medically important since it transmits Chagas disease via feces and urine that contain the parasite Trypanosoma cruzi. In adult females, ecdysteroid hormone (20-hydroxyecdysone, 20E) is involved in the growth of the ovary and development of eggs post-blood meal (PBM). Halloween genes are essential for ecdysteroid synthesis since they code for cytochrome P450 enzymes in the ecdysteroidogenic pathway. The ecdysone receptor (EcR/USP) binds 20E, resulting in activation of ecdysone-responsive genes. We have identified and characterized the Halloween genes, and the non-Halloween gene, neverland, in the R. prolixus ovary using transcriptomic data. We used BLAST to compare transcriptome sequences with other arthropod sequences to identify similar transcripts. Our results indicate that the Halloween genes, neverland and ecdysone receptor transcripts are present in the ovaries of R. prolixus. We have quantified, by qPCR, Halloween gene transcript expression in the ovary following a blood meal. Most of the Halloween genes are upregulated during the first 3 days PBM. Knockdown of EcR, USP and shade transcripts, using RNA interference, results in a significant reduction in the number of eggs produced and a severe reduction in egg laying and hatching rate. Furthermore, knockdown of the EcR or shade transcripts altered the expression of the chorion gene transcripts Rp30 and Rp45 at day 3 and 6 PBM. These results indicate that ecdysteroids play critical roles in reproduction of female R. prolixus.
Plasmodium knowlesi infection in East Kalimantan, Indonesia
Authors: Gunawan Carta A. , Siagian Loly R.D. , Prasetya Edwin
Published: October 2022

Plasmodium knowlesi is the fifth species of plasmodium infecting humans and the infection was first discovered in Southeast Asia in 2004. The incidence has been increasingly reported from almost all Southeast Asian countries, including Indonesia. Although the global incidence of malaria has decreased around 50% in the last decade, the increase of knowlesi malaria infection which can cause severe malaria is of concern. During the period of 2018 to 2021, there were seven newfound cases of knowlesi malaria infection in patients treated at hospital in Samarinda, East Kalimantan, Indonesia. The clinical manifestations and laboratory examinations of these patients are described here. All patients were male and worked in mining and palm oil plantations in the forest in several districts in East, North, and South Kalimantan. The diagnosis was based on microscopic examination of Giemsa-stained thin blood smear and confirmed by polymerase chain reaction (PCR) test. Antimalarial treatment was artemisinin-based combination therapy (ACT) / dihydroartemisinin-piperaquine (DHP) fixed-dose combination via oral administration for three days with the doses were based on body weight. All knowlesi malaria patients in this report were presented as uncomplicated cases with great response to ACT after 2-3 days of administration without any adverse effects. Besides fever, gastrointestinal symptoms were major symptoms. Anemia was rare, leukocyte count was normal, however thrombocytopenia was found in all patients. P. knowlesi infection has been discovered in East Kalimantan Province and recently the incidence might be higher than the reported cases, making it resemble an iceberg phenomenon. Therefore, we should build awareness of the rapid increasing of knowlesi malaria cases and its prevention.
Monitoring an archaeological excavation using photogrammetry and digital elevation models (DEMS): the case study of Barranco León in Orce (Granada, Spain).
Authors: González-Quiñones Juan José , Reinoso-Gordo Juan Francisco , Solano-García José Antonio , Cámara-Donoso José Miguel , León-Robles Carlos Alberto , Linares-Matás Gonzalo , Jiménez-Aren Juan Manuel
Published: October 2022

In this paper, we describe and discuss emergent digital technologies employed for monitoring the excavations at the archaeological site of Barranco León (Granada, Spain) between 2017 and 2020. The method entails the following material requirements: a total station, a conventional camera, a computer and a software that integrates photogrammetry algorithms; in terms of human resources, the presence of an engineer for the first day of the excavation to set up the methodological process and trained excavation staff to perform said method on a daily basis is necessary. Here we present the daily workflow for monitoring archaeological excavations introduced at the site, followed by an estimation of the costs and a summary of the results obtained. The method introduced here is based on the height difference of Digital Elevation Models (DEMs) computed on successive days using photogrammetric techniques. It is a non-invasive method, which requires less than 8% of the economic resources of the excavation and can be carried out in less than 15 minutes. This allows the excavation director to have an accurate and visual idea of the excavation process in order to make appropriate decisions. In addition, from the results obtained in the method (differences in DEM of every two days), other derived results can be obtained such as the exact location of the archaeological remains extracted based on their size. These features highlight the relevance and applicability of this approach to a wide range of archaeological sites.
La laguna de L’Albufera y la ciudad romana de Pollentia (Alcúdia, Mallorca): una primera aproximación a su configuración y usos en la Antigüedad.
Authors: Vallori Márquez Bartomeu , Cau Ontiveros Miguel Ángel , Orfila Pons Margarita
Published: October 2022

El aprovechamiento en la Antigüedad de las lagunas litorales con diferentes fines, en especial para un uso portuario, es un fenómeno que ha suscitado el interés de la investigación y en el que se han producido avances notables en las últimas décadas. En este sentido, en Pollentia, claro exponente de ciudad romana abierta al comercio mediterráneo, el uso de las lagunas cercanas estaba apenas definido hasta fechas recientes. El objetivo del presente estudio es ofrecer un marco general de la evolución histórica de la laguna litoral de L’Albufera de Mallorca, situada al NE de la isla y cerca de Pollentia, haciendo especial énfasis en su configuración en época romana y su posible uso como zona portuaria. Para ello, se revisan estudios geológicos, cartografía histórica georreferenciada y hallazgos arqueológicos. La información disponible, gestionada mediante herramientas GIS, permite proponer la existencia de una laguna separada del mar por una flecha litoral, al menos navegable por pequeñas embarcaciones, que habría sido utilizada para actividades portuarias. La presencia de esta laguna fue uno de los factores que favorecieron la fundación de Pollentia en este enclave, y el devenir de ambas estuvo sin duda ligado. Palabras clave Islas Baleares, Alcúdia, puertos, lagunas litorales, cartografía, geomorfología.
Practice Prize Report: The 2020 and 2022 ISMS Gary Lilien Practice Prize Competition
Authors: Luo Lan , Pauwels Koen
Published: October 2022

This report summarizes the finalists of the ISMS Gary Lilien Marketing Science Practice Prize Competition.
From Micro to Macro Gender Differences: Evidence from Field Tournaments
Authors: De Sousa José , Hollard Guillaume
Published: October 2022

We document that women compete worse against men in field tournaments in over 150 countries and across all ages. Our field setting is the game of chess and we benefit from a large and rich data set to investigate the robustness and heterogeneity of our uncovered gender differences in competition. We find a macro gender gap in every country: there are fewer female than male players, especially at the top, and women have lower average rankings. Moreover, comparing millions of individual games, we find a small but robust micro gender gap: women’s scores are about 2% lower than expected when playing a man rather than a woman with an identical rating, age and country. Using a simple theoretical model, we show how this small micro gap may affect women’s long-run human-capital formation. By reducing effort and increasing the probability of quitting, both effects accumulate to explain a larger share of the macro gap.

This paper was accepted by Yan Chen, behavioral economics and decision analysis.

Supplemental Material: The e-companion and data are available at https://doi.org/10.1287/mnsc.2022.4541 .
Employment Flexibility and Capital Structure: Evidence from a Natural Experiment
Authors: Kuzmina Olga
Published: October 2022

Using a unique panel data set of manufacturing firms in Spain in 1994–2006, I show that the use of flexible (shorter and cheaper-to-fire) employment contracts promotes debt financing. I build the identification strategy on the intertemporal, cross-regional, and cross-gender variation in government subsidies that differentially encouraged firms to hire workers on the less flexible contracts. A thought experiment of prohibiting an average firm from hiring workers on flexible contracts suggests that such a firm should reduce its debt-to-capital ratio by 7%. These findings suggest that flexible employment contracts reduce operating leverage and the fixity of firms’ costs, increasing financial leverage. The unique institutional environment allows me to isolate this mechanism from collective bargaining and total labor cost channels. I further show that employment flexibility increases firm performance for firms that benefit most from operating leverage reductions and depend more on external financing. The results demonstrate how management can use heterogenous labor contracts to improve firm outcomes.

This paper was accepted by Gustavo Manso, finance.

Supplemental Material: The online appendix is available at https://doi.org/10.1287/mnsc.2022.4560 .
A Rising Tide Lifts All Boats: The Effects of Common Ownership on Corporate Social Responsibility
Authors: DesJardine Mark R. , Grewal Jody , Viswanathan Kala
Published: October 2022

Common owners face an incredible investment challenge: managing systematic risk. Because common owners hold shares in multiple firms across an industry, an action (or inaction) by one firm that affects industry peers is felt more severely by common owners than by non-common owners. Research has largely focused on common owners’ role in orchestrating competitive dynamics among their portfolio firms, with almost no empirical investigation of how common owners manage systematic risk. Drawing on research showing that one firm’s corporate social responsibility (CSR) can produce positive spillovers for peer firms and that its irresponsibility can harm its peers, we argue that common owners increase firms’ CSR to produce spillovers that reduce systematic risk and multiply their investment returns. Consistent with our theory, we find that common ownership is positively associated with firm CSR. Unpacking that relationship, we find that increases in CSR are driven by common owners with long-term orientations and are concentrated in stakeholder sensitive industries, in which CSR spillovers are most economically impactful. We also find that common owners focus their efforts on financially material CSR over financially immaterial CSR. We use a natural experiment with a quasi-exogenous shock to rule out alternative explanations. Our study contributes to literatures on the antecedents of CSR and outcomes of common ownership, providing a new perspective on how common owners shape corporate strategic behavior.

Supplemental Material: The online appendix is available at https://doi.org/10.1287/orsc.2022.1620 .
Simplified superoscillatory lenses for super-resolution imaging
Authors: Qi Rui , Gbur Gregory J.
Published: October 2022

In recent years, superoscillations have become a new method for
creating super-resolution imaging systems. The design of
superoscillatory wavefronts and their corresponding lenses can,
however, be a complicated process. In this study, we extend a recently
developed method for designing complex superoscillatory filters to the
creation of phase- and amplitude-only filters and compare their
performance. These three types of filters can generate nearly
identical superoscillatory fields at the image plane.
Hybrid structure polarization-maintaining hollow-core photonic bandgap fiber with anti-resonant tubes and silicon layers
Authors: Hu Kailing , Lou Shuqin , Jia Haoqiang , Wang Xin
Published: October 2022

A novel-hybrid structure polarization-maintaining 19-cell hollow-core photonic bandgap fiber (HC-PBGF) is proposed. Robust single-mode characteristic is achieved by introducing six anti-resonant tubes into the core of 19-cell HC-PBGF. A high birefringence at the level of 10−3 is achieved by adding silicon layers into the y-direction tubes. The higher-order mode extinction ratio (HOMER) is greater than 4.71 × 107, and the high birefringence can be improved to 5 × 10−3. In the waveband from 1530 nm to 1595 nm, the single-mode, high birefringence performance can be effectively maintained even under a tight bending radius of 5 mm.
Synergistically designed antireflective cover for improving wide-angle photovoltaic efficiencies
Authors: Kim Jae-Hyun , Cho Jin-Woo , Jeon Injun , Jeong Kyung Taek , Kang Hyuk-Jun , Choi Dae-Geun , Kim Jae Hyun , Kim Sun-Kyung
Published: October 2022

We demonstrated that a well-designed nanopatterned cover improves photovoltaic efficiency across a wide range of incident angles (θ). A nanopatterned cover was created using an integrated ray-wave optics simulation to maximize the light absorption of the surface-textured Si photovoltaic device. A hexagonally arranged nanocone array with a 300 nm pitch was formed into a polymer using nanoimprinting, and the nanostructured polymer was then attached to a glass cover with an index-matching adhesive. Angle-resolved current density-voltage measurements on Si photovoltaic devices showed that the nanopatterned glass cover yielded a 2–13% enhancement in power conversion efficiency at θ = 0–60°, which accounted for its broadband antireflective feature. We performed all-season-perspective simulations based on the results of the integrated ray-wave optics simulations and solar altitude database of South Korea, which validated the sustainability of the developed nanopatterned cover during significant seasonal fluctuations.
COVID-19 self-testing, a way to “live side by side with the coronavirus”: Results from a qualitative study in Indonesia
Authors: Thomas Catherine , Shilton Sonjelle , Thomas Caroline , Iye Claudius Mone , Martínez-Pérez Guillermo Z.
Published: October 2022

Alongside mass vaccination for COVID-19, sustainable diagnostic strategies for SARS-CoV-2 are needed to empower local communities and help them complement health authorities’ efforts to end the pandemic in low- and middle-income countries. Indonesia is among the nations with an overstretched health system that may benefit from technological innovations, such as rapid SARS-CoV-2 antigen-detection tests for self-testing, to detect asymptomatic cases and interrupt the transmission of the virus to healthy individuals. In mid-2021, we conducted a qualitative research study with the aim of understanding key decision-makers’ values and preferences regarding the implementation of COVID-19 self-testing in Indonesia. This research received ethics approval from the Universitas Katolik Indonesia Atma Jaya and used a thematic analysis approach to explore the insights expressed by healthcare workers, representatives of civil society, and potential self-testing implementers in three geographies: Jakarta, Banten, and North Sulawesi. Thirty semi-structured interviews and six focus group discussions were carried out. As per the informants’ narratives, the Indonesian public might accept rapid SARS-CoV-2 antigen-detection self-testing as a tool that will enable them to test for COVID-19 at their own convenience. Concerns were expressed that the public might doubt the reliability of self-testing kits if these were not properly regulated and if counterfeit kits were known to be on the market. Fear of stigma, isolation, and clinical care costs were perceived to be among the drivers for self-test users to not report a reactive result. These fears might be mitigated, as per the informants’ opinions, by awareness raising, passing of regulations, and participatory engagement of a range of community actors, such as village officers. Decision-makers consider rapid SARS-CoV-2 antigen-detection self-testing to be a welcomed screening tool that could contribute to ensuring earlier access to treatment and decrease transmission of SARS-CoV-2 in Indonesia.
A capability perspective on sustainable employability: A Dutch focus group study on organizational, work and personal conversion factors
Authors: Meerman Jan , van Casteren Patricia A. J. , Brouwers Evelien P. M. , van Dam Arno , van der Klink Jac J. L.
Published: October 2022

Objective

In the field of work, there is a shift towards more value-based approaches to study the sustainable employability of the present-day worker. The capability approach offers a value based and innovative conceptualisation and framework of sustainable employability characterized by contextuality, normativity and diversity. The capabilities of Dutch employees have been established and validated, yet it is not known which conversion factors on a personal, work and organizational level enable employees to achieve value in work in different Dutch occupational sectors.

Methods

Our qualitative approach included seven focus groups in different occupational sectors including elderly care, higher education, insurance work, facility management and the oil-, car- and chemical industry. Each focus group included 5–11 participants and took approximately one and a half hour. A qualitative content analysis was used to analyse the data, by combining deductive and inductive coding respectively. Deductive coding involved assigning themes to the conversion of resources into capabilities at the organizational, work and personal level.

Results

On the organizational conversion level, important themes were cultural aspects, power relations, shortage of personnel and policies for self-management. On the work conversion level, social contacts, communication and workload, tasks and schedules were identified. Social contacts were described as a work value in itself, but also conditional for achieving other work values. On the personal conversion level, experienced work stress, motivation and the ability to achieve values informally within the company.

Conclusion

From our findings it follows that focus groups are sensitive to identify conversion factors on all three levels of conversion. In addition, companies and their employees might effectively increase work capabilities by being sensitive to all three conversion levels simultaneously. Further research is necessary to study the effect of a capability-based intervention at the work floor.
Telemedicine may increase visit completion rates in postpartum patients with preeclampsia
Authors: Sanghavi Monika , Packard Elizabeth , Sperling Santina , Eberly Lauren A. , Ambrose Marietta , Julien Howard M. , Hirshberg Adi , Adusumalli Sri , Lewey Jennifer
Published: October 2022

Postpartum cardiovascular (CV) evaluation of women with preeclampsia is recommended to screen for and treat modifiable risk factors to reduce lifetime CV risk. However, attendance at in-person postpartum obstetric and cardiology clinic visits is low. The aim of this study was to compare the completion rate of new patient telemedicine visits to in-person office visits for patients with preeclampsia referred for postpartum hypertension management and CV risk assessment at a single center. There were 236 unique new patient visits scheduled during the study period. The average age was 30.3 years, 73.7% patients were Black, and 56.7% had Medicaid insurance. The completion rate was 32% for in-person clinic visits and 70% for telemedicine visits. Women who did not complete an office visit were more likely to be Black (87% vs. 56%, p < 0.01) and younger (29.1 vs. 31.4 years, p = 0.04) compared to those who completed a visit. Notably, this difference was not seen with telemedicine visits. Telemedicine may provide a novel opportunity to improve the care for blood pressure management and CV risk reduction in a vulnerable population at risk of premature CV disease.
Fractional lower order linear chirplet transform and its application to bearing fault analysis
Authors: Long Junbo , Wang Haibin , Fan Hongshe , Lao Zefeng
Published: October 2022

The amplitude and frequency of the mechanical bearing fault vibration signals vary with time, and which are non-stationary and non-Gaussian process. The fault signals belong toαstable distribution, and the characteristic index 1 <α< 2, even the noises areαstable distribution in extreme cases. The existing linear chirplet transform (LCT) degenerates, even fails underαstable distribution environment. A fractional low order linear chirplet transform (FLOLCT) which takes advantage of fractionalporder moment is presented forαstable distribution noise environment, and the corresponding FLOLCT time-frequency representation (FLOLCTTFR) is developed in this paper. By employing a series of polynomial chirp rate parameters instead of a single chirp rate of the FLOLCT method, a fractional low order polynomial linear chirplet transform (FLOPLCT) is developed to improve time frequency concentration of the signals. The improved FLOLCT and FLOPLCT methods are used to compare with the existing LCT and PLCT methods based on second order statistics, the results reveal performance advantages of the proposed methods. Finally, the FLOLCT and FLOPLCT methods are applied to analyze the fault signature of the bearing ball fault data in the position of DE (Drive end accelerometer) and extract their fault signature, the result illustrates their performances.
We know but we hope: A qualitative study of the opinions and experiences on the inclusion of management, health economics and research in the medical curriculum
Authors: Turner Astrid , Ryan Mandy , Wolvaardt Jacqueline
Published: October 2022

The achievement of global and national health goals requires a health workforce that is sufficient and trained. Despite considerable steps in medical education, the teaching of management, health economics and research skills for medical doctors are often neglected in medical curricula. This study explored the opinions and experiences of medical doctors and academic educationalists on the inclusion of management, health economics and research in the medical curriculum. A qualitative study was undertaken at four medical schools in Southern Africa (February to April 2021). The study population was medical doctors and academic educationalists. Semi-structured interviews with purposively sampled participants were conducted. All interviews were recorded and professionally transcribed. Constructivist grounded theory guided the analysis with the use of ATLAS.ti version 9.1.7.0 software. In total, 21 academic educationalists and 28 medical doctors were interviewed. In the first theme We know, participants acknowledged the constraints of medical schools but were adamant that management needed to be taught intentionally and explicitly. The teaching and assessment of management and health economics was generally reported to be ad hoc and unstructured. There was a desire that graduates are able to use, but not necessarily do research. In comparison to management and research, support for the inclusion of health economics in the curriculum was insignificant. Under We hope, educationalists hoped that the formal clinical teaching will somehow instil values and best practices of management and that medical doctors would become health advocates. Most participants wished that research training could be optimised, especially in relation to the duration of allocated time; the timing in the curriculum and the learning outcomes. Despite acknowledgement that management and research are topics that need to be taught, educationalists appeared to rely on chance to teach and assess management in particular. These qualitative study findings will be used to develop a discrete choice experiment to inform optimal curricula design.
Seeking dramatic reality in the digital world
Authors: Schubert Maria
Published: October 2022

More than two years after the beginning of the COVID-19 pandemic, online drama therapy seems to be viewed both by therapists and clients in an extreme way: either as a means of salvation in the limitations of distance and quarantine restrictions or as a discount to in-person therapy. In this conceptual article, the author explores the ways in which online drama therapy utilizes aesthetic distance and dramatic reality. The author theorizes how these concepts translate into an online space without breaking the relationship between therapist and client/group that is already being hindered by the literal distance, the lack of body involvement and the mediation of technology and the screen. Through discussion of the existing literature on aesthetic distance and fantastic/dramatic reality, the author examines these concepts through the lens of the online setting, providing some thoughts that might be of use when planning an online session.
Connections between therapeutic circus arts and drama therapy: A qualitative content analysis of core processes
Authors: Elowe Rebecca , Schorr Siggi , Faith Emily , Alters Brett , Wood Laura L.
Published: October 2022

Therapeutic circus arts (TCA) present a new arena for drama therapy, capitalizing on the historical connection between circus and theatre arts. To evaluate whether drama therapy core processes also present in TCA, we conduct a qualitative content analysis of research articles centred on TCA (N= 40). Selected articles were thematically coded, showing that all of drama therapy’s core processes also appear in the TCA literature. Of those processes, ‘empathy and distancing’, ‘play’, ‘life-drama connection’ and ‘transformation’ were especially prominent. Implications include the potential for knowledge sharing and future collaboration between the TCA and drama therapy fields.
Examining drama therapy practices through the lens of dis/abled-clinicians-in-training
Authors: Cook Angelle , Young Kelly , McFann Caitlin , Angier Marie
Published: October 2022

This clinical commentary discusses the experiences of three dis/abled drama-therapy-clinicians-in-training. Through three vignettes, each written by one of the students, reflections and observations are offered on how drama therapy programs may inadvertently support ableist practices and how these can and are being shifted to create more inclusive spaces. Recommendations are offered for drama therapy trainers and students alike, both in the classroom and in the field.
Ethnodramatherapy: Integrating Research, Therapy, Theatre and Social Activism into One Method, Stephen Snow (2022)
Authors: Bailey Sally
Published: October 2022

Review of: Ethnodramatherapy: Integrating Research, Therapy, Theatre and Social Activism into One Method, Stephen Snow (2022)

London: Routledge and Taylor & Francis, 304 pp.,

ISBN 978-0-36753-947-4, p/bk, $39.95
Creative Arts Therapy Careers: Succeeding as a Creative Professional, Sally Bailey (ed.) (2022)
Authors: Lukic Venus
Published: October 2022

Review of: Creative Arts Therapy Careers: Succeeding as a Creative Professional, Sally Bailey (ed.) (2022)

New York: Routledge, 258 pp.,

ISBN 978-0-36747-652-6, h/bk, $128

ISBN 978-0-36747-653-3, p/bk, $27.96

ISBN 978-1-00303-566-4, e/bk, $27.96
Comparison of MANTA vs ProGlide Vascular Closure Device and 30-Day Outcomes in Transfemoral Transcatheter Aortic Valve Implantation
Authors: Eftychiou Christos , Eteocleous Nicolaos , Mitsis Andreas , Zittis Ioannis , Papadopoulos Kyriacos , Petrou Andria , Adamou Maria , Kounnos Christos , Bekos Christos , Avraamides Panayiotis
Published: October 2022

Background

Vascular complications (VCs) after transfemoral transcatheter aortic valve implantation (TAVI) have an increased mortality risk, and vascular closure device (VCD) use is mandatory. The percutaneous MANTA VCD (Teleflex) is a novel collagen-based technology for closure of large-bore arteriotomies. We compared the MANTA VCD with the suture-based ProGlide VCD (Abbott Vascular).

Methods

A retrospective review was performed on all consecutive patients who underwent transfemoral TAVI in our center from January 1, 2015, to February 28, 2021, and 30-day outcomes were recorded. Major adverse cardiovascular events (MACE) were cardiac death, disabling stroke, and/or major VCs. Access site–related VCs were VCs related to the access site vessel from which the transcatheter valve was introduced and advanced.

Results

The MANTA VCD was used in 99 patients and the ProGlide in 224. There was 4.0% MACE in the MANTA group and 4.9% in the ProGlide group (P = .999). Overall VCs were 10.1% vs 7.6%, major VCs were 3.0% vs 2.2%, and minor VCs 7.1% vs 5.4%(P = .753). Access site–related VCs were 5.1% vs 5.8% in the (P = .999), and periprocedural vascular surgical intervention was needed in 6.1% of the MANTA group vs 2.2% of the ProGlide group (P = .099).

Conclusion

There was no significant difference in MACE, mortality, cardiovascular mortality, VCs, access site–related VCs, periprocedural vascular surgical interventions, bleeding, or transfusion rate between the 2 groups. The MANTA VCD group had more periprocedural vascular surgical interventions which did not reach statistical significance.
MACROSCOPICS AND MICROSCOPICS FEATURE OF WITAR RATS LIVER AFTER IMMERSION IN GRADUAL CONCENTRATION OF RANDU HONEY
Authors: Kusuma Putri Ariani , Dhanardhono Tuntas , Saebani Saebani , Purnawati Ratna Damma , Istiadi Hermawan
Published: October 2022

Background Formaldeyde is main substance used for organ embalming and even for foods preservations. However, long and high exposure of formaldeyhde lead to various organs irritations. Honey is well-known for its natural preservative activity expected to be the soultion for the problem so there is safe alternative for organ preservations.Aim Observation and examintaion the difference of macroscopic and microscopics feature of Wistar rats liver after immersion of formaldehyde and randu honey.Methods Experimental with post-test only control group design using 24 male Wistar rats as sample, randomly divided into 4 groups consist of: Group C (preserved with 10% formaldehyde solutions), P1 (preserved with 10% randu honey solutions), P2 (preserved with 20% randu honey solutions) and P3 (preserved with 30% randu honey solutions). The sampels were preserved for 24 hours then macroscopic (smell,color and size) and microscopic study with Hematoxylin-Eosin (HE) stain  using 400x observation performed. Manja Roenigk score were used to accessed the degree of live microsopic damage.Results There are normal cells, mild damage, moderate damage and severe damage respectively in the group C: 36%,47%,17%,0% ; P1: 0%,27%,46%,27% ; P2: 0%,77%,17%,6% ; P3: 47%,33%,17%,3%. Kruskal-Wallis test showed significant results with p=0.000. With Mann-Whitney test, significant results were found between group C with P1 (0.000), C with P2 (0.006), P1 with P2 (0.000), P1 with P3 (0.000) and P2 with P3 (0.003). However, test result were not significant berween group C with P3 (0.684).Conclusions There were differences in macroscopics and microscopic features between Wistar rats liver after immersion in formaldehyde and randu honey. The best features showed in samples preserved in 30% Randu Honey solutions.
A REVIEW OF THE MONKEYPOX OUTBREAK IN INDONESIA IN 2022
Authors: Sari Meiriani , Hairunisa Nany
Published: October 2022

Monkeypox disease (monkey smallpox) is a disease that has never been found in Indonesia since it was first discovered in humans in the Congo in 1970. So if there is one positive confirmed event, then the disease is an Extraordinary Event (KLB). This disease has become a global concern because since May 13, 2022, WHO has received reports of Monkeypox cases from non-endemic countries. It has expanded to 4 WHO regions: Europe, America, Eastern Mediterranean, and Western Pacific. Until now, further investigations and studies are still being carried out to understand more about the epidemiology, sources of infection, and transmission patterns in non-endemic countries that have reported new cases, such as Indonesia. Until now, no specific treatment has been proven to treat Monkeypox infection. Currently, the therapy used is symptomatic support. The antiviral tecovirimat, or TPOXX, developed by the European Medicines Agency (EMA) as a Monkeypox therapy in 2022 based on research, has not been marketed freely. In addition, antivirals such as cidofovir and brincidofovir have been shown to be effective against orthopox virus in vitro and in animal studies. However, the effectiveness of this drug against monkeypox in humans is not yet known. However, this disease can be prevented by vaccination. In Indonesia, the Modified Vaccinia Ankara-Bavarian Nordic (MVA-BN) vaccine is recommended to prevent Monkeypox disease. The existence of the outbreak report is important to discuss, explore, and understand more about the disease and its management and prevention.
EVALUASI USER EXPERIENCE SSO UNDIP MENU SIAP BERDASARKAN PERSEPSI MAHASISWA TEKNIK INDUSTRI MENGGUNAKAN USER EXPERIENCE QUESTIONNAIRE (UEQ)
Authors: Susanto Novie
Published: October 2022

Penggunaan media online terus berkembang pesat seiring berjalannya waktu. Salah satunya adalah penggunaan SSO pada berbagai lembaga, termasuk Universitas Diponegoro. web SSO ini bermanfaat untuk aktivitas seperti mengakses email, e – journal, dan kegiatan administrasi seperti pengisian KRS dan her – registrasi. Berdasarkan studi pendahuluan yang telah dilakukan diketahui bahwa mahasiswa memiliki keluhan mengenai fitur website dan tampilannya terutama pada menu SIAP. Beberapa diantaranya mengenai website yang kurang rapi, beberapa fitur tidak terintegrasi langsung dengan aplikasi, sistem input nilai yang tidak teratur, kurang transparan dalam nilai dan nama pengambil mata kuliah (rawan kecurangan). Oleh karena itu dibutuhkan perbaikan terhadap website SSO pada menu SIAP agar dapat meningkatkan kepuasan pengguna. Penelitian ini dilakukan dengan mengidenifikasi kekurangan menu SIAP dengan menggunakan kuisioner User Experience Questionnaire (UEQ). Setelah itu dilakukan perancangan perbaikan dengan menggunakan aplikasi axure, yang kemudian dilakukan pengujian kembali pada desain rancangan perbaikan dengan menggunakan meiode yang sama untuk mengetahui apakah rancangan perbaikan lebih baik daripada SIAP existingnya.
IMPLEMENTATION OF THE DMAIC APPROACH FOR QUALITY IMPROVEMENT AT THE ELASTIC TAPE INDUSTRY
Authors: Kurnia Hibarkah , Jaqin Choesnul , Manurung Hasiholan
Published: October 2022

The scope of this research is in one of the textile industries with elastic tape produced on the weaving machine, which has decreased production due to production defects that do not meet the target. This research aims to determine the leading causes of dominant defects, increase the sigma level with Six Sigma methods, and propose improvements to be included in the Key Performance Indicators (KPI) method. The results of this study that the dominant factor causing the defect is the curved elastic tape defect, which consists of the machine factor, and the method. Factors driving the machine include the hook like a side thread lock that is often bent and the difference in the thickness of the tape between the left, middle and right. The causative factor of this method is checking the thickness of the elastic band only in the center position. The results of corrective actions impact increasing the sigma level by 10% from 3.3339 to 3.6832. In contrast, repair defects can reduce defects before repair by 18.92% and after repair by 9.23%. It is proposed to be included in the KPI so that the weaving department can control and be enthusiastic about continuous improvement.
SPATIAL ANALYSIS OF REGIONAL POVERTY IN CENTRAL JAVA INDONESIA
Authors: Anwar Aminuddin
Published: October 2022

This study analyzes the effect of the spatial interaction of poverty in districts/cities in Central Java for three periods, 2010, 2015, and 2019. The method used in this research is a spatial analysis using Global Moran's I Statistics, Local Indicator of Spatial Association (LISA), and spatial regression with Spatial Autoregressive Model (SAR). Spatial distribution analysis concluded that the high concentration of poverty for three periods occurred in the southern part of Central Java, accompanied by a high concentration of unemployment and population. The results of non-spatial regression analysis concluded that there was a negative effect of economic growth on poverty, a positive influence of population on poverty in Central Java for the three study periods, and a negative effect of education on poverty only in 2019. The estimation model uses SAR as the best model chosen to explain poverty conditions in Central Java, and it shows that poverty in neighboring areas has a positive value, so it can be concluded that there is a spatial effect of poverty in Central Java. The spatial influence of poverty implies that the government carries out an integrated poverty alleviation program to produce policies that have local impacts in one area but must have a spatial impact, which means reducing poverty between regions.
PENGARUH PENGELUARAN PEMERINTAH, INVESTASI, JUMLAH PENDUDUK, KEMISKINAN TERHADAP PERTUMBUHAN EKONOMI DAN INDEKS PEMBANGUNAN MANUSIA: Analisa Two Stage Least Square untuk Kasus Indonesia
Authors: Simarmata Yuli Wantri , Iskandar Deden Dinar
Published: October 2022

Indeks pembangunan manusia merupakan suatu indeks komposit untuk mengukur capaian pembangunan manusia berbasis sejumlah komponen dasar kualitas hidup. Pertumbuhan ekonomi merupakan kunci dari penurunan kemiskinan disuatu wilayah, dengan adanya pertumbuhan ekonomi berarti terdapat peningkatan produksi sehingga menambah lapangan pekerjaan yang pada akhirnya akan mengurangi kemiskinan maka indeks pembangunan manusia akan dapat dinilai meningkat. Penelitian ini bertujuan untuk mengetahui bagaimana pengaruh pertumbuhan ekonomi terhadap indeks pembangunan manusia serta melihat faktor-faktor yang mempengaruhi pertumbuhan ekonomi dan indeks pembangunan manusia di Indonesia.  Analisis data dalam penelitian menggunakan data panel 34 provinsi di Indonesia Tahun 2013-2018. Dalam mengestimasi structure equation model (SEM) dalam penelitian ini menggunakan metode Two Stage Least Square (TSLS). Hasil penelitian ini menunjukan bahwa variabel pertumbuhan ekonomi berpengaruh signifikan terhadap indeks pembangunan manusia.
Analisis Kekuatan Massa Batuan dan Stabilitas Lereng Intake Bendungan Bener Berdasarkan Metode Empiris, Analitis, dan Numerik
Authors: Danuartha Muhammad Satya Himawan , Widianto Hendratama
Published: October 2022

Berdasarkan hasil redesain terowong pengelak Bendungan Bener memiliki panjang trase ±853 m, dengan tinggi lereng intake dan inlet sebesar 130 m. Fungsi bendungan ini selama konstruksi berlangsung digunakan untuk mengalihkan aliran Sungai Bogowonto, tetapi ketika operasional berfungsi sebagai bangunan pengambilan untuk air baku dan PLTA. Penelitian ini menyajikan hasil investigasi geologi teknik galian intake dan portal inlet terowong pengelak Bendungan Bener. Karakteristik massa batuan diperoleh dari pemetaan geologi teknik (scanline). Sifat indeks dan keteknikan batuan diperoleh dari hasil laboratorium sampel batuan. Analisis stabilitas lereng pada intake dengan metode empiris dilakukan berdasarkan klasifikasi massa batuan, metode analitis berdasarkan metode ambang batas kesetimbangan, metode numerik berdasarkan  metode elemen hingga. Investigasi geologi menunjukkan lokasi terowongan tersusun oleh breksi andesit, yang merupakan bagian dari Formasi Kebo Butak. Massa batuan pada area studi galian intake dominan segar dan lapuk ringan berdasarkan Rock Mass Rating, RMR juga diklasifikasikan sebagai massa batuan kelas I (massa batuan sangat bagus) dan kelas II (massa batuan bagus). Berdasarkan  Slope Mass Rating, desain lereng inlet berada pada kelas II (stabil). Hasil analisis stabilitas sumbu utama lereng intake alami dan setelah penggalian menggunakan metode ambang batas kesetimbangan dan metode elemen hingga berada pada kondisi aman (Faktor keamanan >1,5).
Estimasi Cadangan Batugamping di Lapangan Bukit Tajarang PT Semen Padang sebagai Bahan Baku Pembuatan Semen
Authors: Ali Rinal Khaidar , Fadhli Kurnia , Widiarso Dian Agus
Published: October 2022

Bukit Tajarang merupakan lapangan tambang baru yang diharapkan mampu memenuhi kebutuhan semen yang dibutuhkan PT Semen Padang. Perhitungan cadangan dilakukan untuk mengetahui jumlah cadangan batugamping pada lokasi tambang tersebut, sehingga dapat disesuaikan dengan target produksi dan umur tambang. Tujuan penelitian adalah mengetahui jumlah cadangan batugamping pada lokasi penelitian dan menentukan umur tambang. Metode yang digunakan adalah metode penaksiran cadangan dalam bentuk permodelan block model dengan menggunakan software Surpac 6.3.2, dan metode estimasi berupa Inverse Distance Weighting. Data berupa 27 titik bor, kemudian data bor tersebut diklasifikasikan menjadi data collar, data survey, data litologi, dan data asssay, kemudian menggunakan data topografi daerah penelitian. Berdasarkan pada perhitungan yang dilakukan, estimasi jumlah cadangan pada daerah penelitian adalah 144.368.325 ton. Berdasarkan pada target produksi PT Semen Padang yaitu 9,.362.746 ton/tahun dan jumlah estimasi cadangan yang telah didapatkan sebelumnya, maka estimasi umur tambang pada daerah penelitian adalah 15 tahun 3 bulan.