bluuebunny/crossref_metadata_2025 huggingface dataset:
Variability of Ocean Features and their Impact on Cyclogenesis over Arabian Sea During Post Monsoon Season
Authors: Bhowmick suchandra Aich , Mandal Anup
Published: June 2021

Arabian Sea (AS), the western sector of North Indian Ocean (NIO) produce smaller number of tropical cyclones as compared to Bay of Bengal. Though limited in numbers, the cyclones over Arabian sea are catastrophic by character. This make west coast of Indian subcontinent vulnerable to these hazards. The post-monsoon cyclogenesis over this region is known to be modulated by both monsoon rainfall and the El-Niño accompanied with positive Indian Ocean Dipole events. No single phenomena, however, can fully explain the variability observed in AS region. In this study, it is observed that apart from several known atmospheric forcings, inter-annual variability of ocean heat content (OHC) influence the post-monsoon AS cyclogenesis. The OHC of this region is partially modulated by the changes in salinity. Heat exchanges between the South West Indian Ocean (SWIO) and AS also modulates the OHC over AS. This remote influence is facilitated largely by the variability in the equatorial currents. Further it is seen that the recent trend of increased OHC post-2011 matches with the enhanced sea surface carbon over AS.
Semiquantitative Characterizations And Controlling Factors of Microscopic Pore Characteristics of The Metamorphic Rock Reservoir In The Central Paleo-Uplift Belt, Songliao Basin
Authors: Zeng Zhouqiang , Shan Xuanlong , Hao Guoli , He Wentong , Zheng Changqing , Yi Jian , Guo Jiannan
Published: June 2021

Currently, metamorphic rock is a common target for oil and gas exploration, and reservoirs are the key factors restricting hydrocarbon exploration and development in metamorphic rocks. The deep metamorphic rock gas reservoir in the central paleo-uplift of the northern Songliao Basin has good exploration and development potential. In this study, we use a combination of qualitative descriptions and quantitative analysis to comprehensively analyze the pore characteristics of the reservoir and explore the factors controlling the pore characteristics of the metamorphic rock reservoir in the central paleo-uplift belt of the Songliao Basin. The metamorphic rock reservoir in the central paleo-uplift belt contains three types of lithologies: chlorite schist, mylonite, and mica schist, each with different protoliths and metamorphic histories. The reservoir space can be divided into 4 pore types, and the reservoir space of each lithology is quite different. The results of high-pressure mercury intrusion and nitrogen adsorption indicate that the pore size distributions of the schist and mylonite differ. Compared with the schist, the mylonite has less reservoir space, stronger homogeneity, larger pore size, smaller specific surface area, more natural gas reservoir space and stronger natural gas adsorption capacity. This paper also studies the formation process of the reservoir and divides it into four stages. Finally, this article discusses in detail the factors controlling the microscopic pore characteristics of metamorphic rock reservoirs in the central paleo-uplift belt; the metamorphic rock protolith is the most important controlling factor.
Application of Machine Learning Algorithm to Predicting Metabolic Syndrome in Adults
Authors: Mirzaei Narmin , Mostadaei Shayan , Najafi Farid , Darbandi Mitra , Pasdar Yahya
Published: June 2021

Background

The prevalence of the metabolic syndrome (MetS) is increasing worldwide. Early detection of the MetS by valid and available indicators can help prevent, control and reduce its complications. This study aims to identify of most important anthropometric, biochemical and nutritional indices for predicting MetS.
Methods

This study conducted on 9,602 participants from baseline data of the Ravansar Non-Communicable Disease (RaNCD) cohort study including of adults aged 35–65 years. The reference model for MetS was considered according to International Diabetes Federation (IDF) criteria. We used a wrapper algorithm and area under ROC curve (AUC) for selection and assessing most important predictors of MetS.
Results

The importance value (IV) for components of the models for prediction of MetS was confirmed, before implementing the models. Identified model with components of age, waist circumference (WC), body mass index (BMI), fasting blood sugar (FBS), systolic-diastolic blood pressure (SBP-DBP), triglyceride (TG), hip circumference (HC) and AUC of 0.893 (95% CI: 0.884–0.902) for men and 0.867 (95% CI: 0.853–0.881) for women was a strongest model for predictive of MetS risk. The AUC (95% CI) for non-invasive model was 0.756 (0.746–0.766) in total population has a good predictive power for MetS risk with components of age, WC, BMI, SBP, DBP.
Conclusion

This study demonstrated that in addition to aggressive models, models non-invasive (anthropometric indices, blood pressure and energy intake) can be also a good and convenience screening tool to predict the MetS. The models, in addition to the application of clinical diagnosis, can be widely used in researches on large populations.
23% power conversion efficiency light-emitting diodes using monolayer quantum dots
Authors: Fan Fengjia , Gao Yan , Liu Xiaonan , Li Bo , Shen Huaibin , Song Yang , Song Jiaojiao , Chong Yihua , Yao Ruyun , Wang Shujie , Li Lin Song , Du Zuliang
Published: June 2021

Ever since the first proposal of using colloidal quantum dots (QDs) as the active emitting layer of light-emitting diode (LED), a monolayer of QD is considered as a better option than the multilayer ones. Owing to the slow charge transport rate among different QD layers, quantum dot light-emitting diodes (QLEDs) adopting multilayer QDs need to be driven at higher than the bandgap bias voltage to achieve practically useful brightness, resulting in increased power consumptions and heat generations, and reduced device lifetimes. Unfortunately, QLEDs using monolayer QDs always suffer from unwanted recombination in hole transport layers (HTLs) and low external quantum efficiencies (EQEs) as a result of electron overflow from QDs into HTLs. Herein, we tackle this dilemma by packing QDs with large size into monolayers, which enables us to mitigate the unwanted electron overflow and retain high EQE. More importantly, it further allows us to boost the irradiative recombination current at bandgap voltage. By virtue of simultaneously obtained high EQE and irradiative recombination rate, we can achieve brightness of 1,100 cd m-2 and 3,000 cd m-2 at 100% and 105% bandgap voltages with record high power conversion efficiencies (PCEs) of 23% and 22%, respectively. Since heat generation has been depressed and devices can be operated at reduced bias voltage, they show unprecedented T95 operation lifetimes (the time for the luminance to decrease to 95% of the initial value) of more than 4,000 h with an initial brightness of 3,000 cd m-2, and equivalent T95 lifetimes of more than 20,000 h at 1,000 cd m-2.
An Unstoppable Marathon: Community Prevention and Residents' Sense of Security in the Period of Low Transmission
Authors: Shen Xin , Feng Jing , Lei Zihui , Cao Hui , Zhao Yuxin , Gan Yong
Published: June 2021

The authors have requested that this preprint be removed from Research Square.
Metformin Attenuates Silica-induced Pulmonary Fibrosis via AMPK Signaling
Authors: Cheng Demin , Xu Qi , Wang Yue , Li Guanru , Sun Wenqing , Ma Dongyu , Zhou Siyun , Liu Yi , Lei Han , Ni Chunhui
Published: June 2021

Background: Silicosis is one of the most common occupational pulmonary fibrosis caused by respirable silica-based particle exposure, with no ideal drugs at present. Metformin, a commonly used biguanide antidiabetic agent, could activate AMP-activated protein kinase (AMPK) to exert its pharmacological action. Therefore, we sought to investigate the role of metformin in silica-induced lung fibrosis.Methods: The anti-fibrotic role of metformin was assessed in 50 mg/kg silica-induced lung fibrosis model. SiO2-stimulated lung epithelial cells/macrophages and TGF-β-induced differentiated lung fibroblasts were used for in vitro models.Results: At the concentration of 300 mg/kg in the mouse model, metformin significantly reduced lung inflammation and fibrosis in SiO2-instilled mice at the early and late fibrotic stages. Besides, metformin (range 2mM to 10mM) reversed SiO2-induced cell toxicity, oxidative stress, and epithelial-mesenchymal transition process in epithelial cells (A549 and HBE), inhibited inflammation response in macrophages (THP-1), and alleviated TGF-β1-stimulated fibroblast activation in lung fibroblasts (MRC-5) via an AMPK-dependent pathway.Conclusions: In this study, we identified that metformin might be a potential drug for silicosis treatment.
Intrauterine Device utilisation amongst short term contraceptive users in Hossana Town, Southern Ethiopia: a qualitative study
Authors: Woldeyohannes Demelash , Arega Abinet , Mwanri Lillian
Published: June 2021

BackgroundIntrauterine devices (IUDs) are one of the long-acting, safe and effective methods of contraception in women across the world. However, this method is underutilised in many countries, including Ethiopia. Several quantitative studies have been used to address this problem and generated a list of factors associated with this problem. However, this list lacks detailed and local contexts that are necessary to inform local solutions. The current study uses a qualitative method to explore determinants of IUDs underutilization among short term modern contraceptive users from the maternal health services in the study setting. The use of a qualitative study design is necessary to obtain and rich contextual details that can inform the development of locally appropriate strategies to increase the IUDs uptake in the study area and improve women’s reproductive health outcomes.MethodA qualitative study was conducted in Hossana town public health facilities, southern Ethiopia from November 1–30, 2019. A total of thirteen in-depth interviews were conducted including with: 11 short term contraceptive users, one health centre head and one health extension worker. The interview guide comprised semi-structured questions. Interviews were audio recorded, transcribed and collected data analysed thematically.ResultThe main key determinants of IUDs service underutilisation were identified from participants’ narratives, including: (i) poor knowledge about the benefits of IUDs, (ii) insufficient counselling and ineffective delivery of health information to aid women in decision making, (iii) the absence of trained health personals, and shortage of supplies.ConclusionResults indicate that the poor utilisation of IUDs services is determined by both the service provider and the consumer related factors. Poor knowledge of short term users of contraception is a critical factor because without knowledge, clients may not use the available services effectively. The shortage of necessary supplies, poor provider-client relationships, and poor counselling by service providers are also service factors that act as barriers to uptake of IUDs. Efforts should be made to increase IUDs utilization by focusing on educating women about the importance of IUDs, improving counselling of mothers and strengthening the health systems, including allocating more resources to increase access to IUDs among the service users.
Baseline Insulin Levels may Predict Response to Low Glycemic Index Complete Nutrition Formula: A Randomized Cross-Over Control Trial
Authors: Wongniyomkaset Warisara , Rungraung Numphung , Muangpracha Niramol , Winuprasith Thunnalin , Trachootham Dunyaporn
Published: June 2021

Background: Personalized intervention is crucial for effective nutritional advice to prevent diabetes. However, specific characters of the responders to low glycemic index (low GI) diet was unclear. This study was aimed to identify glycemic index and factors affecting response to the low glycemic complete nutrition formula.Method: A randomized cross-over controlled trial was conducted in 18 healthy volunteers (fasting plasma glucose < 100 mg/dL). All participants consumed complete nutrition drink with retrograded starch, glucose solution and white bread (35 g carbohydrate each) in a random sequence with 14-day wash-out intervals. The GI value of complete nutrition drink was determined from area under the curve (AUCi) of postprandial glucose, using glucose solution and white bread as references. Baseline characters of responders (with low GI of complete nutrition drink) and non-responders were compared and correlated to identify factors affecting their responses to the low GI complete nutrition drink. Results: The adjusted GIs for complete nutrition drink with retrograded starch were 48.2 ± 10.4 and 46.7 ± 12.7 when using glucose solution and white bread as the reference food, respectively. Baseline insulin level was the only parameter showing difference between responders and non-responders. The response correlated with baseline insulin (r = 0.4997, p = 0.0347), but was independent of fasting plasma glucose (r = 0.0456, p = 0.8574) and others. Conclusions: In healthy volunteers with normal blood glucose levels, adequate baseline insulin level was the only factor correlated with the response to low glycemic complete nutrition drink. Screening for fasting insulin level may be encouraged for personalized nutrition of low GI diet.Trial registration: TCTR, TCTR20210305001. Registered 4 March 2021 - Retrospectively registered, http://www.thaiclinicaltrials.org/ TCTR20210305001
Open Innovation in Healthcare Ecosystem – a systematic review
Authors: Torab-Miandoab Amir , Samad-Soltani Taha , Rezaei-hachesu Peyman
Published: June 2021

Background: Several countries are facing significant troubles of health services, particularly rising prices. Innovative technologies and services are expected to help boost medical quality and cut costs. In this sense, there is a lack of innovative work in spite of a growing interest in open innovation and approaches that advocate for expanded cooperation among various actors in healthcare. Objective: This paper describes the findings of a study concerning the commitment of the healthcare sector to open innovation. Materials and methods: The search for literature focused on English-language papers to 12 January 2020. Based on the indicated criteria for inclusion, 29 articles were included. Results: Results show that most experiments concentrate on the areas of pharmaceutical research (drug discovery) and health informatics (health information systems and infrastructures) that were brought out as concepts or applied as pilot and prototype. Conclusions: The participation of the healthcare sector limited in open innovation, and more work is required with an emphasis how to get open innovation.
Preclinical Drug Testing of the CDK 4/6 Inhibitor Palbociclib in Combination With a PI3K or MEK Inhibitor in Colorectal Cancer Cell Lines
Authors: LEE CHA LEN , Aslam Razia , Cremona Mattia , Kennedy Sean , Madden Stephen , Carr Aoife , Farrelly Angela , Workman Julie , Toomey Sinead , Hennessy Bryan
Published: June 2021

Background: Studies have demonstrated the efficacy of Palbociclib (CDK 4/6 inhibitor), Gedatolisib (PI3K/mTOR dual inhibitor) and PD0325901 (MEK1/2 inhibitor) in colorectal cancer (CRC), however single agent therapeutics are often limited by resistance. The main purpose of this in vitro study is to comprehensively test two drug combinations [Palbociclib with Gedatolisib (P+G) and Palbociclib with PD0325901 (P+PD)] to determine the most synergistic combination for clinical development. Methods: We compared the anti-proliferative effects of both drug combinations in five CRC cell lines with various mutations (Caco-2, DLD-1, LS1034, SNUC4 and LS411N). Reverse Phase Protein Arrays was used to investigate the effects of P+G on the total and phosphoproteins of the signalling pathways. Results: Our results from toxicology experiments indicated that the P+G is a superior combination. The combination of P+G had synergistic anti-proliferative effects in all cell lines [CI range: 0.11-0.69]. The combination of P+PD is also synergistic in all cell lines [CI range: 0.06-0.44], except LS411N with BRAF V600E mutation [CI=14.7]. The combination of P+G caused significant suppression of S6rp(S240/244) in all cell lines, without AKT reactivation. This indicated efficient blockage of PI3K/AKT/mTOR pathway, even in PIK3CA mutated cell lines. The combination of P+G induced BAX and Bcl-2 levels in PIK3CA mutated cell lines. The combination of P+G caused MAPK/ERK reactivation, as seen in total EGFR increase and this was not mutationally exclusive. Conclusion : This in vitro study demonstrated that the combination of P+G has synergistic anti-proliferative effects in both wild-type and mutated CRC cell lines. This data provides good rationale for further in vivo studies for P+G novel combinative therapy in CRC. Separately, the S6rp(S240/244) may serve a promising biomarker of responsiveness.
Kinetic field theory: Non-linear cosmic power spectra in the mean-field approximation
Authors: Bartelmann Matthias , Dombrowski Johannes , Konrad Sara , Kozlikin Elena , Lilow Robert , Littek Carsten , Pixius Christophe , Fabis Felix
Published: June 2021

We use the recently developed Kinetic Field Theory (KFT) for cosmic
structure formation to show how non-linear power spectra for cosmic
density fluctuations can be calculated in a mean-field approximation to
the particle interactions. Our main result is a simple, closed and
analytic, approximate expression for this power spectrum. This
expression has two parameters characterising non-linear structure growth
which can be calibrated within KFT itself. Using this self-calibration,
the non-linear power spectrum agrees with results obtained from
numerical simulations to within typically \lesssim10\,\%≲10%
up to wave numbers k\lesssim10\,h\,\mathrm{Mpc}^{-1}k≲10hMpc−1
at redshift z = 0z=0.
Adjusting the two parameters to optimise agreement with numerical
simulations, the relative difference to numerical results shrinks to
typically \lesssim 5\,\%≲5%.
As part of the derivation of our mean-field approximation, we show that
the effective interaction potential between dark-matter particles
relative to Zel’dovich trajectories is sourced by non-linear cosmic
density fluctuations only, and is approximately of Yukawa rather than
Newtonian shape.
Los primeros comentadores protestantes de la Ética a Nicómaco (1532-1599) y el problema de la mutabilidad de la ley natural
Authors: Svensson Manfred
Published: June 2021

El artículo ofrece una introducción al conjunto de los comentarios a la Ética a Nicómaco escritos por autores protestantes durante el siglo XVI. Se corrige así la unilateral impresión que el antiaristotelismo de Lutero ha dejado sobre la historia intelectual del periodo. Exponemos el modo en que estos comentadores tratan la idea de lo justo por naturaleza en EN V, 7, y en particular la singular tesis aristotélica sobre la mutabilidad de lo justo natural.
Subjetividad y subjetivación en Marx: una lectura confrontativa a partir de Heidegger y Foucault
Authors: Ayala-Colqui Jesús
Published: June 2021

El artículo dilucida el concepto de “subjetividad” en Karl Marx y lo analiza, de manera sucesiva, desde una perspectiva heideggeriana y foucaultiana. Más precisamente, determina críticamente la pertinencia de las categorías elaboradas por Heidegger y Foucault en el análisis del concepto marxiano señalado. Para ello, el trabajo se divide en tres apartados. Primero, se indaga por el concepto de “subjetividad” en la obra de Marx. Segundo, se reconstruye una lectura heideggeriana de tal concepto a partir de elementos del “primer” y “segundo” Heidegger. Tercero, se ensaya una lectura foucaultiana de dicho concepto a partir de las coordenadas de las nociones de “gubernamentalidad”, “veridicción” y “subjetivación”. Se concluye que la lectura de Heidegger resulta insuficiente y la de Foucault parcialmente suficiente, lo que no excluye, sin embargo, la posibilidad de matizarlas a fin de desarrollar, con los aportes de los tres filósofos, una suerte de “marxismo postheideggeriano y post-foucaultiano”.
Silver and zinc oxide nanoparticle disinfection in water treatment applications: synergy and water quality influences
Authors: Venis Robbie A. , Basu Onita D.
Published: June 2021

The synergistic potential of silver and zinc oxide nanoparticles for water disinfection was investigated herein. By causing cell death through membrane interactions, oxidative killing, and DNA deactivation, metallic nanoparticles may be integrated with point-of-use water treatment systems for applications in rural and remote geographies. Disinfection efficacy was evaluated in batch-phase experiments under both synthetic and real water conditions, where synthetic water was varied by pH and dissolved oxygen levels. Ceramic pot filters with comparative nanoparticle concentrations were also investigated. In all cases, combinations of silver and zinc nanoparticles resulted in improved disinfection in comparison to either metal in isolation. In batch experiments, dissolved oxygen proved to be particularly impactful, with kinetic rates reducing approximately 45% when in low oxygen environment (<3 mg/L) versus high oxygen (>8 mg/L). Log removal values (LRVs) were further, on average, 31% lower in real water than synthetic water after 300 min, though silver–zinc combinations were still superior to either metal alone. In filters, those impregnated with 67% silver and 33% zinc achieved average LRVs of 2.7 and 2.9 after 60 min of filtration and 24 h of storage, respectively, while those with only silver achieved average LRVs of 2.0 and 3.1 at those same times.
Spatio-temporal change in rainfall over five different climatic regions of India
Authors: Ray Litan Kumar , Goel Narendra Kumar
Published: June 2021

The present study deals with the estimation of dependences, spatio-temporal trends, change points, and stationarity in rainfall and rainy day series (1901–2013) for five (out of six) different climatic regions of India. Only one-fourth of the station rainfall and rainy day datasets exhibits long-term dependence on an annual and seasonal basis. The presence of lag-one serial correlation is prominent for almost all the climatic regions of India. The significant decreasing trend is found mainly for the stations of semi-arid and humid sub-tropical regions. The magnitude of rainfall is decreasing for most parts of the study area by 10% for annual and monsoon seasons. The change point is presented in a smaller number of stations. Non-stationary behaviour is observed for the rainy day series of semi-arid and humid sub-tropical regions, which may increase the temporal variability of rainfall over the same regions. The findings of this study could be very useful for the planning and management of water resources of different climatic regions of India.
A LUDICIDADE COMO ESTRATÉGIA DE EDUCAÇÃO EM SAÚDE BUCAL NO CENTRO DE ATENÇÃO PSICOSSOCIAL ÁLCOOL E DROGAS: RELATO DE EXPERIÊNCIA
Authors: Vieira Alves Caroline , Alves da Silva Tatiane , Euler de Sousa Lucena Eudes
Published: June 2021

Introdução: A educação em saúde bucal tem um papel importante na conscientização dos usuários do CAPS AD. A natureza das substâncias de abuso, lícitas ou ilícitas causam um efeito devastador para os tecidos bucais e prejuízo à qualidade de vida. Objetivo: O objetivo deste trabalho é descrever uma oficina de construção de jogos para promover o cuidado em saúde bucal no CAPS AD da cidade de Caicó/RN. Metodologia: A oficina de construção de jogos ocorreu durante o mês de maio de 2019 na vivência dos residentes, do Programa de Residência Multiprofissional em Atenção Básica da EMCM/UFRN no CAPS AD. A atividade foi conduzida pela dentista residente e utilizou-se o espaço das oficinas de artesanato, que faziam parte da rotina do serviço. Resultados: Foram produzidos quatro jogos educativos e um quadro com orientações de higiene bucal, que ficaram disponíveis para os usuários do serviço. Conclusões: Essa atividade além de ser uma oportunidade de ócio criativo pode facilitar a fixação dos conteúdos da educação em saúde bucal que são abordados dentro do jogo, incentiva a discussão sobre o tema e estimula o autocuidado, reforçando e orientando as boas práticas de higiene.
A EDUCAÇÃO EM SAÚDE NO PROCESSO DE TRABALHO DOS PROFISSIONAIS DA ESTRATÉGIA SAÚDE DA FAMÍLIA: UM RELATO DE EXPERIÊNCIA
Authors: Sousa de Brito Antônia Fernanda , Macena Sousa Ciliane
Published: June 2021

Introdução: A Estratégia Saúde da Família é constituída de equipes multiprofissionais que devem atuar numa perspectiva interdisciplinar, articulando suas práticas e saberes no enfrentamento de cada situação identificada para propor soluções, e intervir de maneira apropriada a cada realidade. Desse modo, emergem as ações educativas como ferramenta indispensável para estimular o autocuidado nos usuários. Objetivo: Relatar a experiência de acadêmicas do curso de enfermagem a partir da construção de espaços de Educação em Saúde, abordando a temática: o contexto das hepatites virais. Metodologia: Estudo descritivo, tipo relato de experiência. As atividades foram desenvolvidas em uma Unidade de Atenção Primária à Saúde, localizado no município de Quixeré/CE. Resultados: Percebeu-se que a partir da intervenção foi possível despertar momento de reflexão a cerca da assistência em saúde, inclusive em relação às percepções da biossegurança, favorecendo assim a troca e compartilhamento de saberes. Tal atividade contribuiu, ainda, para a construção e o aprimoramento do saber-fazer no tocante a um dos seus processos de trabalho, o ensinar-aprender. Conclusões: A Educação em Saúde propõe-se a contemplar os princípios do Sistema Único de Saúde por intermédio da promoção da saúde e da conscientização do indivíduo e da comunidade a fim de garantir a autonomia dos sujeitos.
ESTRATÉGIAS DE HUMANIZAÇÃO DA ASSISTÊNCIA NO AMBIENTE HOSPITALAR: REVISÃO INTEGRATIVA
Authors: Dayse de Oliveira Ferreira Julyenne , Neri Correia Campos Taynah , Erivelton Medeiros Dias Danilo , Luna da Silva Ivanaldo , Hamana de Macedo Dantas Thaissa , De Sousa Dantas Diego
Published: June 2021

Introdução: Este artigo apresenta uma revisão sistemática da literatura referente às estratégias de humanização no ambiente hospitalar. Objetivo: identificar e analisar a produção de conhecimento acerca das estratégias que as instituições e profissionais de saúde têm implementado para humanizar a assistência nesse ambiente. Metodologia: O levantamento de artigos foi realizado Literatura Latino Americana e do Caribe (Lilacs), Medical Literature Analysis and Retrieval System Online (MedLine), Portal de Periódicos da Capes, Scientific Eletronic Library Online (SciELO) orientado pela questão norteadora: quais as estratégias de humanização da assistência que têm sido implementadas no ambiente hospitalar? Foram incluídos artigos originais de pesquisa observacional; publicados em português, inglês ou espanhol; sem limites quanto ao ano de publicação. Resultados: No total, 20 artigos compuseram o corpo de análise da revisão e sintetiza exemplos de estratégias implementadas em diversos serviços hospitalares. Conclusões: as estratégias encontradas oferecem subsídios para que os profissionais e gestores possam multiplicá-las, ampliando e melhorando a sua realidade. Porém, cabe observar que ao criar essas ambiências deve-se conhecer e respeitar a particularidade das instituições em que está se operando, para que seja possível comparar e avaliar se a utilização da estratégia resultará em benefícios e eficácia.
O IMPACTO DO USO DE SUBSTÂNCIAS PSICOATIVAS E SUAS REPERCUSSÕES NA CAVIDADE BUCAL: REVISÃO INTEGRATIVA
Authors: Lira Farias Teotônio Maria Helena , Da Silva Lima Vitória , Da Silva Andrade Kauana , Maria de Melo Costa Bianca , Cristina Tavares de Medeiros Honorato Maria
Published: June 2021

RESUMO

Introdução: O consumo de drogas pode promover consequências para o organismo, sobretudo a cavidade bucal.  Objetivo: Verificar quais são as substâncias psicoativas mais utilizadas e suas repercussões na cavidade bucal.  Metodologia: Foi realizada uma revisão de literatura na base de dados Medical Publications (PubMed) com os descritores “Transtornos Relacionados ao Uso de Substâncias (Substance-Related Disorders)” e “Odontologia (Dentistry)” com o operador booleano “And”. Resultados: A amostra foi composta por 5 artigos selecionados, onde a maconha, cocaína e o crack foram as substâncias psicoativas mais utilizadas pelos usuários de drogas, sendo a perda dentária, presença de cárie dentária e doença periodontal as principais repercussões bucais. Conclusões: O consumo de substâncias psicoativas aumenta o limiar de dor, podendo mascarar a sintomatologia dolorosa das manifestações bucais e postergar a busca por tratamento odontológico, agravando, por vezes, a condição bucal do indíviduo. Sendo portanto, de extrema importância o conhecimento e atuação do cirurgião dentista frente ao usuário de drogas, desde a prevenção, diagnóstico e tratamento do caso.

Palavras-Chave: Transtornos relacionados ao uso de substâncias; Odontologia, Manifestações bucais.
EDUCAÇÃO EM SAÚDE PARA SENSIBILIZAR ADOLESCENTES ESCOLARES PARA A VACINAÇÃO CONTRA O PAPILOMA VÍRUS HUMANOS
Authors: Machado Flávia Christiane de Azevedo , da Silva Moura Adriely Fernanda , Cabral Teixeira Ylari , Dantas Campelo Maria Carolina , Medeiros da Rocha Neto Agenor , Freire Oliveira Kedma Valnice , Macedo e Medeiros Ysla Kallena
Published: June 2021

Introdução: Educação em saúde visa sensibilizar a consciência cidadã a partir do conhecimento do sujeito e de estratégias pedagógicas dialógicas. Tal atividade pode envolver os diferentes ciclos de vida, como crianças e adolescentes. Objetivo: relatar a experiência de um grupo tutorial da disciplina SACI II da UFRN na produção e realização de ações de educação em saúde voltadas a sensibilização para adesão a vacinação contra o HPV no território adscrito a uma USF de Natal/RN no primeiro semestre do ano de 2018. Metodologia: A seleção das temáticas-alvo se deu a partir das percepções dos discentes acerca do contexto epidemiológico do bairro e, sobretudo, dos processos contínuos de escuta ativa, em que profissionais de saúde da USF e lideranças do território expuseram as demandas locais. Utilizou-se a ferramenta CANVAS para estruturação do planejamento estratégico das intervenções. Exposições dialogadas, com uso de multimídia, cartazes, jogos educativos e paródias foram empregados na interação com o público da escola do bairro. Resultados: As percepções do grupo discente foram positivas e satisfatórias ao final das intervenções, em meio à ativa participação dos escolares e interesse nas temáticas abordadas, evidenciando adequação das estratégias realizadas. Conclusões: as intervenções buscaram responder a uma demanda de educação em saúde relativa ao adolescente.  Ademais, contribuíram para o crescimento acadêmico e pessoal dos discentes ao trabalhar competências do saber, do ser, conviver, essenciais a efetivação do modelo da vigilância à saúde, bem como houve um balanço positivo, uma vez que os resultados esperados no planejamento foram alcançados. Desta forma, concretizou-se o princípio da integração ensino-serviço-comunidade.

 

Palavras-Chave: Serviços de Integração Docente-assistencial, Educação em Saúde, Comunicação, Atenção Primária à Saúde, Sistema Único de Saúde.
SEGURANÇA DO AMBIENTE DOMICILIAR E OCORRÊNCIA DE QUEDAS EM PESSOAS IDOSAS
Authors: Dantas do Vale Tavares Zuleika , Dantas Araújo Mayara Priscilla , Medeiros de Araújo Nunes Vilani
Published: June 2021

Introdução: A ocorrência de quedas em pessoas idosas é considerada um problema de saúde pública, acarretando em prejuízos para a saúde, mas que pode ser prevenida a partir da manutenção de um ambiente seguro. Objetivo: Identificar condições relacionadas a ocorrência de quedas e segurança do ambiente domiciliar de pessoas idosas residentes na zona rural de um município do interior do Estado do RN. Metodologia: Foi realizada uma pesquisa-ação com uma das etapas de diagnóstico feito a partir de um estudo analítico e observacional. O estudo foi realizado com agentes comunitários de saúde (ACS) e idosos. Foram realizadas capacitações com os ACS para reconhecimento e identificação dos riscos ambientais de quedas nos domicílios dos idosos. Para coleta de dados, utilizou-se o questionário de avaliação ambiental e quedas da Caderneta de Saúde da Pessoa Idosa. Resultados: Participaram do estudo 288 idosos, dos quais 24,7% relataram ter sofrido queda e desses, 23,9% tiveram fratura óssea. 47,9% das quedas ocorreram dentro de casa, destas 42,2% ocorreram no banheiro. A maioria dos itens de segurança não estava adequado. 53,5% relataram impedimento nas áreas de locomoção, 55,6% não tinham pisos uniformes e tapetes fixos, apenas 27,1% tinham tapete antiderrapante na área do chuveiro, 14,6% afirmaram possuir escada no domicílio, porém, nenhuma apresentava corrimão dos dois lados e firmes e/ou piso antiderrapante. Foram encontradas diferenças significativas entre a ocorrência de queda e a ausência de pisos uniformes e tapetes bem fixos (p<0,001), interruptores acessíveis nas entradas de cômodos (p<0,001), área do chuveiro com antiderrapante (p=0,026) e armários baixos sem necessidade do uso de escadas (p<0,001). Conclusões: A maioria das pessoas idosas vive em um ambiente que favorece a ocorrência de quedas. Enfatiza-se a necessidade de ações de prevenção de quedas e segurança domiciliar tendo em vista suas implicações na qualidade de vida dessas pessoas.
Recent Progress of Machine Learning in Gene Therapy
Authors: Hunt Cassandra , Montgomery Sandra , Berkenpas Joshua William , Sigafoos Noel , Oakley John Christian , Espinosa Jacob , Justice Nicola , Kishaba Kiyomi , Hippe Kyle , Si Dong , Hou Jie , Ding Hui , Cao Renzhi
Published: June 2021

:

With new developments in biomedical technology, it is now a viable therapeutic treatment
to alter genes with techniques like CRISPR. At the same time, it is increasingly cheaper to
perform whole genome sequencing, resulting in rapid advancement in gene therapy and editing in
precision medicine. Understanding the current industry and academic applications of gene therapy
provides an important backdrop to future scientific developments. Additionally, machine learning
and artificial intelligence techniques allow for the reduction of time and money spent in the development
of new gene therapy products and techniques. In this paper, we survey the current progress
of gene therapy treatments for several diseases and explore machine learning applications in gene
therapy. We also discuss the ethical implications of gene therapy and the use of machine learning
in precision medicine. Machine learning and gene therapy are both topics gaining popularity in various
publications, and we conclude that there is still room for continued research and application of
machine learning techniques in the gene therapy field.
Inhibiting TLR9 Signaling Stimulates Apoptosis and Cell Cycle Arrest,
and Alleviates Angiogenic Property in Human Cervical Cancer Cells
Authors: Wang Liehong , Zhang Shengkun , Cai Hua , Qi Qingling , Zhang Chunhua , Qi Ziyi , Huang CuiPing
Published: June 2021

Aims:

The aim of the study was to assess the effect of blocking TLR9 signaling on the proliferation
of cervical cancer cells and its angiogenic property.

Background:

Toll-Like Receptors (TLRs) have been implicated for their crucial role in not only cervical
cancer but also in other malignancies. TLR9 is expressed on an array of cells such as macrophages,
dendritic cells, melanocytes, and keratinocytes and is reported to modulate oncogenesis along with
tumorigenesis by augmenting NF-κB mediated inflammation within the tumor environment. TLR9 has
also been reported to positively regulate oncogenesis within the cervix and as a marker to evaluate
malignant remodeling of cervical squamous cells. Therefore, this study was designed to explore the
functional relevance of blocking the TLR9signaling pathway in cervical cancer cells.

Objective:

The objective of the current study was to investigate the effect of human TLR9 antagonist,
ODN INH-18, on apoptosis and cell cycle regulation, and angiogenic property of human cervical cancer
Caski cells.

Method:

MTT assay was performed to measure cell viability and flow cytometry analysis was performed
to assess cell cycle arrest. Quantitative Real-Time PCR (qRT-PCR) analysis was performed to
measure fold change in the gene expression of various markers of apoptosis, cell cycle regulation, and
angiogenesis.

Result:

The qRT-PCR results showed a higher expression level of TLR9 mRNA in Caski cervical
cancer cells as compared to normal cervical keratinocytes. The apoptotic, angiogenic, and cell cycle
regulatory factors were also deregulated in Caski cells in comparison to normal keratinocytes. The
MTT assay demonstrated that treatment of TLR9 antagonist, ODN INH18, significantly reduced the
proliferation of Caski cells in a dose-dependent manner. Treatment of ODN INH18 led to substantial
cell cycle arrest in Caski cells at G0/G1 phase. Moreover, the qRT-PCR results demonstrated that ODN
INH18 treatment led to suppressed mRNA expression of Bcl-2 and enhanced expression of Bax, signifying
the induction of apoptosis in Caski cells. Moreover, the expression of cyclin D1, Cdk4, and
Cdc25A was found to be reduced whereas expression of p27 was increased in ODN INH18-treated
Caski cells; indicating G0/G1 phase arrest. Interestingly, expression of VEGF and VCAM-1 was found
to be significantly inhibited in ODN INH18-treated Caski cells, substantiating alleviation of angiogenic
property of cervical cancer cells.

Conclusion:

The results of our study suggest that inhibiting TLR9 signaling might be an interesting
therapeutic intervention for the treatment of cervical cancer.
Grave goods from Sveta Lucija (Slovenia) in Groningen (the Netherlands). Contextualising old study collections
Authors: Nijboer Albert J.
Published: June 2021

This paper discusses six tombs from Sveta Lucija (Slovenia) that were bought in 1923 from Prof. Rudolf Much (Vienna) by Prof. Albert Egges van Giffen (Rijksuniversiteit Groningen) for the collection of what is now the Groningen Institute of Archaeology. These tombs, excavated in 1890, form part of one of the largest Hallstatt cemeteries known archaeologically, consisting of thousands of tombs. Walking 40 km north from Sveta Lucija, one can reach the Triglav, at 2864 m the highest mountain of the Julian Alps. The site itself is located in a valley, in a strategic location at the confluence of two rivers emerging in these Alps. During the Iron Age, Sveta Lucija functioned as a transitional site between Italy, the Balkans and Austria. This frontier character is reflected in its entire history, starting in the 8th century BC, when it emerged as a settlement centre. The article provides a biography of old study collections since c. 1850 and discusses the role of some influential archaeologists in the history of the excavations at Sveta Lucija since the 1880s. The article then contextualizes the artefacts held at Groningen, concentrating on the 7th to early 5th century BC. The numerous excavations in the burial grounds and settlement for more than a century, make Sveta Lucija one of the more thoroughly investigated European Iron Age settlement centres with a couple of hundred inhabitants. Finally, the article introduces the still-enigmatic development of the site from an Iron Age centre to a Roman village, addressing the decline of its archaeological visibility during the intervening centuries and its correlation with Celtic groups.
Radiocarbon-based investigations into the authenticity of Mesoamerican artefacts in museum contexts
Authors: Erdil P. , Kuitems M. , Berger M. , Dee M.W.
Published: June 2021

In this article, radiocarbon dating has been used as a tool for investigating the authenticity of two Mesoamerican artefacts from the collection of the National Museum of World Cultures (Museum Volkenkunde), Leiden, the Netherlands. The first artefact is a ceremonial Aztec, possibly a tecpatl, knife, and it is presumed to date to 1300–1500 CE. The second object is a decorated Mixtec skull, presumed to date to 1400–1520 CE. The efficacy of radiocarbon dating was thoroughly tested in this study, especially in regard to the tiny quantities that could be sampled from the skull. However, with the newly revamped radiocarbon facility at the University of Groningen, this was an opportune moment to attempt such research.  Ultimately, a credible result could not be obtained on the skull; however, the ceremonial knife was dated reliably to the Aztec period. The article also discusses the broader issue of whether radiocarbon results can be used as a definitive proof of authenticity and examines the risk-reward nature of radiocarbon testing.
Extended study of biological networks using graph theory
Authors: Vetrík Tomáš
Published: June 2021

We represent biological networks by a function that maps the structure of a network to a number called topological index. Topological indices have been studied for biological networks in which a person transmits a virus to two other people, and a person having the virus is in contact with exactly one other person who got the virus from someone else. We extend research in this area by studying biological networks in which a person transmits a virus to n other people, where n ≥ 2, and a person having the virus is in contact with p other people (0 ≤ p ≤ n-2) who got the virus from some other person.
Implementasi Program “We Love Bali” Berbasis CHSE (Clean, Health, Safety, Environment) dalam Pemulihan Pariwisata Bali
Authors: Candranegara I Made Wimas , Mirta I Wayan , Putra Kadek Agus Febriana
Published: June 2021

We Love Bali is a program created by the Ministry of Tourism and Creative Economy aiming to help tourism businesses in Bali to grow in the midst of new normal era while still paying attention to health protocols. This activity is supported by programs that can make tourists interested with the situation of tourist destinations in Bali. It is hoped that this program will be able to make tourism in Bali recover and the economy will rebound and people are able to return to their normal activities in the midst of the Covid 19 pandemic. This paper employs literature studies and interview to examine the implementation of the program. The descriptive result that emphasizes interviews with tourism actors are supported by data from tourists visiting Bali. The results of this study indicate that We Love Bali program is able to restore the economic condition of the Balinese people to a better condition. And also We Love Bali program is one of the programs implemented to help tourism businesses and the creative economy including hotels, travel businesses, transport businesses, tour guides, restaurants, tourist destinations, MSMEs, and others.
HALAL CHARACTERISTICS OF MICRO, SMALL, AND MEDIUM ENTERPRISES (MSMES) PRODUCTS IN PATEMON VILLAGE, KREJENGAN DISTRICT, PROBOLINGGO REGENCY
Authors: Susanti Dyah Ochtorina
Published: June 2021

This research is motivated by the fact that there are still products of Micro, Small and Medium Enterprises (MSMEs) in Patemon Village, Krejengan District, Probolinggo Regency, which do not yet have a halal certificate, because the product does not meet the halal criteria and the public does not understand about the characteristics of halal. This study aims to analyze and provide an understanding about the characteristics of halal, especially on MSME products in Patemon Village, Krejengan District, Probolinggo Regency. The method used in this research is normative legal research with the statute approach, conceptual approach, and comparative approach. The result of this research showed that halal characteristics of MSME products in Patemon Village can be seen from 2 (two) aspects, namely the material and the process of making it or the event to get it. Therefore, it is suggested that the MSME product producers in Patemon Village to immediately take care of their halal product certification and to the government to disseminate information to the public regarding about characteristics of halal on MSME products.
Biological Parameters of the Bark Beetle, Xylosandrus crassiusculus (Motschulsky) Under Controlled Laboratory Conditions
Authors:   Department of Plant Protection, Sindh Agriculture University, Tandojam-Pakistan, Quresh Khalid Hussain , Solang Abdul Waheed ,   Department of Plant Protection, Sindh Agriculture University, Tandojam-Pakistan, Lanjar Abdul Ghani ,   Department of Plant Protection, Sindh Agriculture University, Tandojam-Pakistan, Marri Jan Muhammad ,   Department of Agriculture, Mir Chakar Khan Rind University, Sibi, Balochistan-Pakistan, Khuhro Sajjad Ali ,   Department of Agriculture, Mir Chakar Khan Rind University, Sibi, Balochistan-Pakistan, Bukero Aslam ,   Department of Entomology, Sindh Agriculture University, Tandojam-Pakistan.
Published: June 2021

Biological parameters of the bark beetle, Xylosandrus crassiusculus (Motschulsky) (Coleoptera: Curculionidae: Scolytinae) was investigated under different temperature regimes (27, 29, 31 and 35ºC). The females reared at 29°C, lived 30.93±2.36 days for oviposition. The female laid a maximum of 6.71±1.89 eggs per day and a maximum of 6.99±1.33 batches per female. Each batch had an average of 13.78±2.01 eggs. The mean total fecundity recorded was 67.8±4.25 eggs, with a shortest egg incubation period. At 29°C, the duration of the larval stage was 20.17±2.89 days, the pupal stage 5.03±1.11 days, and the life span of the adult insect was 29.44±3.19 days. Significant differences (P<0.05) were noted when the duration of the different life stages under 29 and 35ºC were compared, with longer duration at 29°C. Insects reared at 35°C had narrower bodies and smaller sizes. Furthermore, the developmental stages period, including the ovipositional period (days) were negatively correlated with temperature. Keywords: Xylosandrus crassiusculus, bark beetle, biological parameters, temperature regimes.
Device Substantiation for Generating Artificial Rain Drops by Pneumohydraulic Liquid Spraying
Authors: Gorobey V. P. , Moskalevich V. Y. , Godzhaev Z. A.
Published: June 2021

The authors studied the pneumohydraulic device indicators for spraying liquids for irrigation, nutrition and protection of agricultural plants, taking into account the principles of water and energy conservation, based on preliminary gas saturation of sprayed water and the use of a cavitation effect in the design of the aerator unit during ejection and supply of air under pressure. (Research purpose) To determine the technological parameters of a pneumohydraulic device for spraying liquids to obtain controlled dispersive artificial rain and substantiate the choice of its optimal technical parameters depending on the operating modes. (Materials and methods) The authors used an algorithm for calculating parameters in EXCEL or WPS spreadsheet processor and mathematical expressions. (Results and discussion) The authors theoretically determined the minimum and maximum calculated parameters of the constructive solution geometry for spraying the liquid phase: water nozzle, air nozzle channel, mixing cell, middle annular gap, outlet nozzle. They changed indicators of operating water pressure – 0.20; 0.25; 0.30 and 0.35 megapascals; air – 0.25 and 0.30 megapascals, provided the water flow rate from 0.002 to 0.010 liter per second and air – from 0.0005 to 0.0090 kilogram per second. With an increase in the water flow rate within the specified limits and the ejection coefficient from 0.5 to 0.9, a linear increase in the average annular gap diameter from 2 to 15 millimetres was revealed, as well as a nonlinear dependence of the increase in the sprayer mixing cell diameter from 5 to 20 millimetres. The authors showed the possibility of reducing the mixing cell diameter if the water pressure was increased from 0.25 to 0.35 megapascal's and the air pressure was from 0.20 to 0.30 megapascals. They obtained the parameters values for the designed and experimental samples development, which turned out to be significantly less than when operating in the air ejection mode: the outlet nozzle and the middle annular gap – by 16 percent, the air nozzle – by 23, the diameter of the mixing cell – by 50 percent or more. (Conclusions) The authors obtained calculated data to optimize technological parameters and design solutions, which would speed up the manufacture of designed and model samples of the device and its experimental testing for the generation of dispersive artificial rain drops.