bluuebunny/crossref_metadata_2025 huggingface dataset:
HDACs/mTOR inhibitor synergizes with pyrotinib in HER2-positive pancreatic cancer through degradation of mutant P53
Authors: Mao Tiebo , Zhang Xiaofei , Xu Haiyan , Zhang Xiao , Ge Weiyu , Li Shumin , Ma Jingyu , Yue Ming , Xue Shengbai , Cui Jiujie , Wang Liwei
Published: December 2022

Background

Pancreatic ductal adenocarcinoma (PDAC), as a highly lethal malignancy with high mortality, lacks of effective treatment. Canonical therapeutic targets in PDAC demand further verification among which HER2 receptor tyrosine kinase inhibitor pyrotinib as treatment targets has not be decided.

Methods

Anti-PDAC efficacy of pyrotinib was evaluated both in vitro and in vivo using both cell lines and patient-derived xenografts. By screening a large-scale library of 1453 compounds, we identified HDACs/mTOR inhibitor 1 as a promising candidate to synergize with pyrotinib. The combination therapy was evaluated in vitro and in vivo in multiple cell lines and animal models. Furthermore, RNA-seq analysis was performed to reveal the latent molecular mechanism of combination therapy.

Results

In our study, pyrotinib monotherapy was found to be inefficient to anti-PDAC which exhibited limited anti-proliferation effect in vitro and in vivo. Through therapy combined with HDACs/mTOR inhibitor 1, pyrotinib triggered intense apoptosis in PDAC both in cell lines and animal models. Mechanistic analyses revealed that mutant P53 degradation mediated by HDAC inhibition synergized with HER2 and mTOR inhibition.

Conclusions

In conclusion, identification of HDACs/mTOR inhibitor as a synergistic inhibitor, provides a potent therapeutic strategy that targets HER2-positive pancreatic cancer.
Acquisition of antibodies to Plasmodium falciparum and Plasmodium vivax antigens in pregnant women living in a low malaria transmission area of Brazil
Authors: Kassa Meseret W. , Hasang Wina , Barateiro André , Damelang Timon , Brewster Jessica , Dombrowski Jamille G. , Longley Rhea J. , Chung Amy W. , Wunderlich Gerhard , Mueller Ivo , Aitken Elizabeth H. , Marinho Claudio R. F. , Rogerson Stephen J.
Published: December 2022

Background

Pregnant women have increased susceptibility to Plasmodium falciparum malaria and acquire protective antibodies over successive pregnancies. Most studies that investigated malaria antibody responses in pregnant women are from high transmission areas in sub-Saharan Africa, while reports from Latin America are scarce and inconsistent. The present study sought to explore the development of antibodies against P. falciparum and Plasmodium vivax antigens in pregnant women living in a low transmission area in the Brazilian Amazon.

Methods

In a prospective cohort study, plasma samples from 408 pregnant women (of whom 111 were infected with P. falciparum, 96 had infections with P. falciparum and P. vivax, and 201 had no Plasmodium infection) were used to measure antibody levels. Levels of IgG and opsonizing antibody to pregnancy-specific variant surface antigens (VSAs) on infected erythrocytes (IEs), 10 recombinant VAR2CSA Duffy binding like (DBL domains), 10 non-pregnancy-specific P. falciparum merozoite antigens, and 10 P. vivax antigens were measured by flow cytometry, ELISA, and multiplex assays. Antibody levels and seropositivity among the groups were compared.

Results

Antibodies to VSAs on P. falciparum IEs were generally low but were higher in currently infected women and women with multiple P. falciparum episodes over pregnancy. Many women (21%-69%) had antibodies against each individual VAR2CSA DBL domain, and antibodies to DBLs correlated with each other (r ≥ 0.55, p < 0.0001), but not with antibody to VSA or history of infection. Infection with either malaria species was associated with higher seropositivity rate for antibodies against P. vivax proteins, adjusted odds ratios (95% CI) ranged from 5.6 (3.2, 9.7), p < 0.0001 for PVDBPII-Sal1 to 15.7 (8.3, 29.7), p < 0.0001 for PvTRAg_2.

Conclusions

Pregnant Brazilian women had low levels of antibodies to pregnancy-specific VSAs that increased with exposure. They frequently recognized both VAR2CSA DBL domains and P. vivax antigens, but only the latter varied with infection. Apparent antibody prevalence is highly dependent on the assay platform used.
Breast metastasis of signet ring cell carcinoma from the colon: a case report
Authors: Wang Xiao , Zhang Haibo , Lu Yanwei
Published: December 2022

Background

Colon cancer is one of the most common diagnosed malignancies. Despite the use of surgery, chemotherapy, radiotherapy, targeted therapy, immunotherapy, and other comprehensive treatments, distant metastasis is still one of the main causes for dying of colon cancer. The common metastatic site of colon cancer is the liver, lung, and bone. In this article, we report a rare case of breast metastasis of signet ring cell carcinoma from the colon.

Case presentation

A 44-year-old woman was diagnosed with colon cancer and received a radical surgery of colon cancer in 2019. Combined with postoperative pathological and computed tomography (CT) images, a diagnosis of cT3N2M0 mucinous adenocarcinoma of colon (according to AJCC cancer staging manual, Version 8) was established. Adjuvant chemotherapy (XELOX: oxaliplatin 130 mg/m2 on day 1 plus capecitabine 1000 mg/m2 twice daily on days 1 to 14 every 3 weeks for 18 weeks) was performed followed by surgical resection. Fourteen months later, the patient underwent mastectomy for breast mass, which was diagnosed pathologically as metastasis of signet ring cell carcinoma from the colon. XELOX chemotherapy regimen (oxaliplatin 130 mg/m2 on day 1 plus capecitabine 1000 mg/m2 twice daily on days 1 to 14 every 3 weeks for 24 weeks) combined with bevacizumab (7.5 mg/kg on day 1) was used after the mastectomy. The patient had stable disease according to her last examination (RECIST criteria).

Conclusion

It is rare to find a report of a patient of colon cancer that metastasizes to breast. We hope to increase treatment experience for patients with this rare metastasis.
Low diffusion capacity of the lung predicts pneumothorax and chest drainage after CT-guided lung biopsy
Authors: Ruud Espen Asak , Heck Sigurd , Stavem Knut , Søyseth Vidar , Geitung Jon Terje , Ashraf Haseem
Published: December 2022

Objectives

Complications after CT-guided lung biopsy is a burden both for the individual patient and for the overall healthcare. Pneumothorax is the most common complication. This study determined the association between lung function tests and pneumothorax and chest drainage following CT-guided lung biopsy in consecutive patients in a large university hospital.

Results

We prospectively registered 875 biopsy procedures from 786 patients in one institution from January 27th 2012 to March 1st 2017 and recorded complications including pneumothorax with or without chest drainage. Lung function data from 637 patients undergoing 710 of the procedures were available. The association of lung function measures with pneumothorax with or without chest drainage was assessed using multivariable logistic regression analyses. Diffusion capacity for carbon monoxide (DLCO) below 4.70 mmol/min/kPa was associated with increased occurrence of pneumothorax and chest drainage after CT guided lung biopsy. We found no association between FEV1, RV and occurrence of pneumothorax and chest drainage. We found low DLCO to be a risk factor of pneumothorax and chest drainage after CT-guided lung biopsy. This should be taken into account in planning and performing the procedure.
Effect of Inactivated and mRNA COVID-19 Vaccination on Thyroid Function Among Patients Treated for Hyperthyroidism
Authors: Wong Chun Ho , Leung Eunice Ka Hong , Tang Lawrence Chi Kin , Lee Chi Ho , Fong Carol Ho Yi , Lee Alan Chun Hong , Woo Yu Cho , Tan Kathryn Choon Beng , Lui David Tak Wai
Published: December 2022

Context

Reports of thyroid dysfunction following COVID-19 vaccination included cases of relapse of Graves' disease and worsening of pre-existing Graves' disease. Little is known about the thyroid-specific outcomes among patients treated for hyperthyroidism who have received COVID-19 vaccination.

Objective

Among patients treated for hyperthyroidism, we evaluated factors associated with not receiving the COVID-19 vaccination and whether COVID-19 vaccination was associated with thyroid function instability.

Methods

We included consecutive patients treated for hyperthyroidism attending the thyroid clinic at a teaching hospital between January and September 2021. They were categorized into vaccinated and unvaccinated groups. The index date was the date of first-dose vaccination for the vaccinated group, and the first date of attendance in the inclusion period for the unvaccinated group. They were followed up until March 2022 or occurrence of thyroid function instability (worsening of thyroid function/increase in antithyroid drug dosage), whichever was earlier.

Results

A total of 910 patients were included (mean age 51.6 years; 82.1% female). Of these, 86.2% had Graves disease and 67.3% were vaccinated (67.3% BNT162b2; 30.6% CoronaVac; 2.1% heterologous). Abnormal thyroid function and cardiovascular comorbidities were independently associated with unvaccinated status. Upon median follow-up of 5.3 months, thyroid function instability occurred in 15.9% of patients. COVID-19 vaccination did not increase risks of thyroid function instability (hazard ratio 0.78, 95% CI 0.56-1.09, P = .151); this was consistent in Graves disease, both types of vaccines, and regardless of whether baseline thyroid function was normal. Twenty-seven patients overtly thyrotoxic at the time of vaccination received COVID-19 vaccines without triggering a thyroid storm or difficulty in subsequent thyroid function control.

Conclusion

Among patients treated for hyperthyroidism, abnormal thyroid function was a factor predicting unvaccinated status. Our results should encourage patients treated for hyperthyroidism to receive COVID-19 vaccination to protect themselves from adverse outcomes and potential long-term sequelae of COVID-19.
Dynamic Testing for Differential Diagnosis of ACTH-Dependent Cushing Syndrome: A Systematic Review and Meta-analysis
Authors: Ceccato Filippo , Barbot Mattia , Mondin Alessandro , Boscaro Marco , Fleseriu Maria , Scaroni Carla
Published: December 2022

Context

Diagnostic accuracy of testing currently used for the differential diagnosis of Cushing disease (CD) vs ectopic adrenocorticotropic hormone secretion (EAS) is difficult to interpret.

Objective

The present study aimed to identify and evaluate the diagnostic accuracy of the corticotropin-releasing hormone (CRH) test, the desmopressin test, and the high-dose dexamethasone suppression test (HDDST) when used to establish a CD or EAS diagnosis.

Methods

This study is a systematic review of the literature and meta-analysis. MEDLINE, OVID, and Web of Science databases were searched for articles published between 1990 and 2021. Articles included described at least 1 test(s) (CRH, desmopressin, or HDDST) and the diagnostic reference standard(s) (histopathology, petrosal sinus sampling, surgical remission, imaging, and long-term follow-up) used to establish a CD or EAS diagnosis.

Results

Sixty-two studies were included: 43 reported the use of the HDDST; 32, the CRH test; and the 21, the desmopressin test. The CRH test was found to have the highest sensitivity in detecting CD (ACTH 86.9%, 95% CI 82.1-90.6, cortisol 86.2%, 95% CI 78.3-91.5) and the highest specificity in detecting EAS (ACTH 93.9%, 95% CI 87-98.3, cortisol 89.4%, 95% CI 82.8-93.7). This resulted in a high diagnostic odds ratio (58, 95% CI 43.25-77.47), large area under the curve, and a receiver operating characteristic of 0.934. The diagnostic accuracy of the HDDST and desmopressin test was lower than that of the CRH test.

Conclusion

The meta-analysis indicates that a patient with a positive ACTH response after a CRH test is highly likely to have CD. Further studies analyzing role of dynamic testing in addition to imaging are needed.
GABA Signaling in the Posterodorsal Medial Amygdala Mediates Stress-induced Suppression of LH Pulsatility in Female Mice
Authors: McIntyre Caitlin , Li Xiao Feng , de Burgh Ross , Ivanova Deyana , Lass Geffen , O’Byrne Kevin T
Published: December 2022

Psychological stress is linked to infertility by suppressing the hypothalamic GnRH pulse generator. The posterodorsal subnucleus of the medial amygdala (MePD) is an upstream regulator of GnRH pulse generator activity and displays increased neuronal activation during psychological stress. The MePD is primarily a GABAergic nucleus with a strong GABAergic projection to hypothalamic reproductive centers; however, their functional significance has not been determined. We hypothesize that MePD GABAergic signalling mediates psychological stress–induced suppression of pulsatile LH secretion. We selectively inhibited MePD GABA neurons during psychological stress in ovariectomized (OVX) Vgat-cre-tdTomato mice to determine the effect on stress-induced suppression of pulsatile LH secretion. MePD GABA neurons were virally infected with inhibitory hM4DGi-designer receptor exclusively activated by designer drugs (DREADDs) to selectively inhibit MePD GABA neurons. Furthermore, we optogenetically stimulated potential MePD GABAergic projection terminals in the hypothalamic arcuate nucleus (ARC) and determined the effect on pulsatile LH secretion. MePD GABA neurons in OVX female Vgat-cre-tdTomato mice were virally infected to express channelrhodopsin-2 and MePD GABAergic terminals in the ARC were selectively stimulated by blue light via an optic fiber implanted in the ARC. DREADD-mediated inhibition of MePD GABA neurons blocked predator odor and restraint stress-induced suppression of LH pulse frequency. Furthermore, sustained optogenetic stimulation at 10 and 20 Hz of MePD GABAergic terminals in the ARC suppressed pulsatile LH secretion. These results show for the first time that GABAergic signalling in the MePD mediates psychological stress–induced suppression of pulsatile LH secretion and suggest a functionally significant MePD GABAergic projection to the hypothalamic GnRH pulse generator.
Modulation of RNA-binding properties of the RNA helicase UPF1 by its activator UPF2
Authors: Xue Guangpu , Maciej Vincent D. , Machado de Amorim Alexandrina , Pak Melis , Jayachandran Uma , Chakrabarti Sutapa
Published: December 2022

The NMD helicase UPF1 is a prototype of the superfamily 1 (SF1) of RNA helicases that bind RNA with high affinity and translocate on it in an ATP-dependent manner. Previous studies showed that UPF1 has a low basal catalytic activity that is greatly enhanced upon binding of its interaction partner, UPF2. Activation of UPF1 by UPF2 entails a large conformational change that switches the helicase from an RNA-clamping mode to an RNA-unwinding mode. The ability of UPF1 to bind RNA was expected to be unaffected by this activation mechanism. Here we show, using a combination of biochemical and biophysical methods, that binding of UPF2 to UPF1 drastically reduces the affinity of UPF1 for RNA, leading to a release of the bound RNA. Although UPF2 is capable of binding RNA in vitro, our results suggest that dissociation of the UPF1–RNA complex is not a consequence of direct competition in RNA binding but rather an allosteric effect that is likely mediated by the conformational change in UPF1 that is induced upon binding its activator. We discuss these results in light of transient interactions forged during mRNP assembly, particularly in the UPF1-dependent mRNA decay pathways.
Effects of continuous renal replacement therapy on Apache-II score, creatinine, and urea nitrogen levels in patients with acute kidney injury
Authors: Hou Huihui , Li Lingzhi
Published: December 2022

Objective: To analyze the effects of continuous renal replacement therapy (CRRT) on acute physiology and chronic health scoring system II (APACHE-II) score, creatinine, and urea nitrogen levels in patients with acute kidney injury (AKI).

Methods: Medical records of 79 patients with AKI treated in Shandong Provincial Third Hospital from January 2019 to January 2021 were retrospectively divided into two groups based on the received treatment. Of them 37 patients received intermittent hemodialysis (IHD) treatment (control group) and 42 patients received CRRT (observation group). Clinical efficacy, survival rate, severity of disease, renal function and serum electrolytels and fluid balance were analyzed.

Results: After the treatment, the total efficacy of the observation group was 95.24%, and the 6-month survival rate was 97.62%, which was higher than 81.08% and 83.78% in the control group, respectively (P<0.05). The Apache-II score of the observation group was (15.76±4.29), which was lower than that of the control group (23.62±5.37). Levels of creatinine, urea nitrogen, and serum levels of potassium (K+), chlorine (Cl-) and sodium (Na+) in the observation group were lower than those in the control group (P<0.05).

Conclusion: CRRT can achieve significant results in the treatment of patients with AKI, help to improve the curative effect, survival rate, alleviate the severity of the disease, recovery of renal functions, the recovery of serum electrolytels and fluid balance.

doi: https://doi.org/10.12669/pjms.39.1.6591

How to cite this: Hou H, Li L. Effects of continuous renal replacement therapy on Apache-II score, creatinine, and urea nitrogen levels in patients with acute kidney injury . Pak J Med Sci. 2023;39(1):50-54. doi: https://doi.org/10.12669/pjms.39.1.6591

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
A comparison of functional and radiological outcome of combine compression antegrade intertrochanteric nail (InterTan) and proximal femoral nail anti-rotation II (PFNA-II) in elderly patients with intertrochanteric fractures
Authors: Zhu Zhonglian , Zhao Zhi , Wang Xuyi , Wang Zhaodong , Guan Jianzhong
Published: December 2022

Objective: To compare the functional and radiological outcome of combine compression interlocking intramedullary nail (InterTan) and proximal femoral nail anti-rotation II (PFNA-II) in the treatment of elderly patients with intertrochanteric fractures.

Methods: As a retrospective cohort study, records of 88 patients with intertrochanteric fractures treated in our hospital from January 1st, 2019 to July 31st, 2021 were retrospectively reviewed. According to treatment records, it included 45 patients treated with InterTan (Group-A) and 43 patients treated with PFNA-II (Group-B). The operation safety and functional rehabilitation of the two groups were compared and analyzed.

Results: This study included 88 patients with intertrochanteric fractures (mean [SD] age, 68.72 [0.10] years at baseline), of whom 52 (59.09%) were males and 36 (40.91%) were females. Operation time and intraoperative blood loss in Group-B were less than Group-A, while fracture healing time was shorter in Group-A. The fracture separation distance was measured four weeks after the operation. The widening rate of the fracture line in Group-A was lower than Group-B (4.4% vs.18.6%; P<0.05). The incidence of complications in Group-A was lower than Group-B (4.4% vs.18.6%; P<0.05). At three, six and twelve months after the operation, the Harris hip score of the two groups was higher than at discharge (P<0.05), with no significant difference between groups (P>0.05).

Conclusions: We found no significant difference in the functional outcome in elderly patients with intertrochanteric fractures treated with InterTan and PFNA-II. Early fracture healing and reduced complication rate however has been noted with InterTan.

doi: https://doi.org/10.12669/pjms.39.1.6946

How to cite this: Zhu Z, Zhao Z, Wang X, Wang Z, Guan J. A comparison of functional and radiological outcome of combine compression antegrade intertrochanteric nail (InterTan) and proximal femoral nail anti-rotation II (PFNA-II) in elderly patients with intertrochanteric fractures. Pak J Med Sci. 2023;39(1):96-100. doi: https://doi.org/10.12669/pjms.39.1.6946

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Αγροδασολιβαδικά οικοσυστήματα
Authors: Πλατής Δημήτριος
Published: December 2022

Οι ενεργειακές ροές στα πολυετή αγροτικά και φυσικά οικοσυστήματα, αποτελούν κρίσιμο παράγοντα και σχετίζονται με εκπομπές αερίων του θερμοκηπίου, καθώς και αυξανόμενες ανάγκες σε νερό. Οι δείκτες ενεργειακής ανάλυσης και τα αποτυπώματα άνθρακα και νερού, είναι χρήσιμα εργαλεία αξιολόγησης των παραγωγικών οικοσυστημάτων, ενώ ταυτόχρονα συμβάλλουν στην ανάδειξη των υπηρεσιών οικοσυστήματος. Οι στόχοι της μελέτης ήταν να προσδιοριστούν και εν συνεχεία να συγκριθούν οι δείκτες ενέργειας και τα αποτυπώματα άνθρακα και νερού γεωργικών καλλιεργειών και λιβαδιών που βρίσκονται σε περιοχή Natura 2000 (Αμβρακικός Κόλπος) για δύο έτη (2018 και 2019). Με τη χρήση της προσαρμοσμένης μεθόδου Αποτίμησης του Κύκλου Ζωής (LCA), οι δείκτες αναδείχθηκαν ως εργαλεία διατήρησης των ανάλογων υπηρεσιών οικοσυστήματος. Με τη μέθοδο της στρωματοποιημένης τυχαίας δειγματοληψίας, επελέγησαν 36 τύποι αγροοικοσυστημάτων (12 ελαιώνες, 12 πορτοκαλεώνες και 12 οπωρώνες ακτινιδίων) και 12 λιβαδικά οικοσυστήματα από τον Δήμο Αμφιλοχίας, Δυτική Ελλάδα. Για την ανάλυση των δεδομένων χρησιμοποιήθηκαν: δείκτες περιγραφικής στατιστικής, η ανάλυση συσχετίσεων, η ANOVA και η ιεραρχική ανάλυση σε συστάδες (ΙΑΣ). Οι κύριες εισροές ενέργειας για τους τρεις τύπους αγροοικοσυστημάτων ήταν τα λιπάσματα και η κατανάλωση καυσίμων. Η μόνη εισροή για τα λιβάδια ήταν η κοπριά. Επιπλέον, η αποτελεσματικότητα χρήσης ενέργειας ήταν υψηλότερη στην ελιά, ενώ ακολούθησαν κατά φθίνουσα σειρά το ακτινίδιο, το λιβάδι και το πορτοκάλι. Το αποτύπωμα άνθρακα ήταν υψηλότερο στο πορτοκάλι και ακολούθησαν κατά φθίνουσα σειρά το ακτινίδιο, η ελιά και το λιβάδι. Το πράσινο νερό ήταν υψηλότερο για το λιβάδι και χαμηλότερο για την ελιά, ενώ το μπλε νερό ήταν μηδενικό για το λιβάδι και υψηλότερο για το πορτοκάλι και το ακτινίδιο. Στην ΙΑΣ, κάθε συστάδα αποτελούνταν από τα ίδια οικοσυστήματα. Τα οικοσυστήματα ελαιώνων και λιβαδιών αποδείχθηκαν φιλικότερα προς το περιβάλλον και μπορούν να συμβάλλουν στην περιβαλλοντική προστασία του Αμβρακικού Κόλπου. Η καλλιέργεια ακτινιδίου, φαίνεται να είναι πιο φιλική προς το περιβάλλον συγκριτικά με αυτήν την πορτοκαλιάς και συνιστάται η καλλιέργειά της στην περιοχή έρευνας. Συμπεραίνεται πως οι δείκτες ενέργειας και τα αποτυπώματα άνθρακα και νερού, είναι χρήσιμα προκειμένου να αναδειχθούν οι ανάλογες υπηρεσίες οικοσυστήματος και οι επιπτώσεις στα οικοσυστήματα
La voz de la mujer literata en el siglo XIX y su metamorfosis en la actualidad.
Authors: Perdomo de León Kimberly
Published: December 2022

La idea primordial del presente escrito es la de dar a conocer los procesos que vivieron las mujeres en el siglo XIX respecto a la discriminación, egocentrismo y sumisión al que fueron sometidas y de cómo la literatura fue predominando para dar valor a estos personajes valientes y esforzados llamados ¨Mujeres literatas¨ que con sus escritos rompieron los moldes, estereotipos y mentes cuadradas que predominaban gracias a las culturas anteriores, con el fin de dar a conocer por medio de la historia , hechos, acontecimientos y fechas importantes que fueron marcando la transición del alza de la voz femenina de un siglo a otro. Como objetivo del escrito también es indagar acerca de las diferentes áreas en las que la mujer fue silenciada pero también la repercusión positiva que se ha logrado gracias al legado de algunas mujeres que a través de la literatura abrieron ese camino que aunque angosto ha ido formándose para que las mujeres expresen ese cumulo de conocimientos que cada una posee y de esta manera motivar las nuevas generaciones a empoderarse y ser mujeres de cambio; empezando en nuestro entorno, para después derribar barreras y llevar ese cambio fuera de nuestra zona de confort, porque no decirlo a otros países , con otras mujeres en el mundo
Zurcir el cuerpo: feminidad, deshilado y costura en Ramona Montiel, de Antonio Berni.
Authors: Vega Ramírez Carolina
Published: December 2022

Este artículo explora el vínculo entre cuerpo y costura en Ramona Montiel, personaje desarrollado por el artista argentino Antonio Berni desde los ’60. Mediante la incorporación de telas, encajes o pasamanerías en los tacos matriceros, sus xilocollages narran la historia de una costurera que –pese a sus esfuerzos y ante la miseria del oficio- incurre en la prostitución para sobrevivir. La particularidad reside en que -como parte de un ejercicio plástico inherente a la vanguardia- dichos restos corresponderían a producciones textiles realizadas por mujeres anónimas; silenciadas por el discurso hegemónico, gracias a la decodificación de patrones difundidos para la modelización del rol femenino en tanto ángel del hogar, reproductor o guardián de ciertos valores tradicionales. Sin embargo, al ser situados en la obra, aquellos retazos y tejidos des/visten el cuerpo de la prostituta, generando una dislocación entre el espacio privado del bordado y el espacio público de la deshonra; mediante la erotización de Montiel y la invisibilización de la mujer real: aquella que borda. En ese sentido, la pose, la cortina, los edredones nos situarían ante ciertas posibilidades de ser/ hacer femenino condicionadas histórica y socialmente; considerando la incursión del propio Berni como fotógrafo clandestino en los prostíbulos de Pichincha, Rosario; a partir de 1932.
Frida Kahlo. Biografie illustrate di un’icona.
Authors: Valecchi Valentina
Published: December 2022

L’immagine di Frida Kahlo è ormai da tempo un’icona universale. Nondimeno la biografia dell’artista, altrettanto nota, sembra capace di toccare le corde più intime dell’animo umano ed è tanto ricca da generare continue riscritture e reinterpretazioni. In particolare, rileviamo la persistenza del personaggio e della sua inconfondibile immagine negli albi illustrati, nei quali, oltre alla passione dell’arte, attraverso la storia e le storie di Frida, emergono i temi dell’identità, della malattia, della disabilità, dell’amore, della fragilità, del genere. Il presente contributo si propone di osservare alcune tra le più significative pubblicazioni dedicate alla pittrice che hanno fatto la loro comparsa nel panorama editoriale destinato ai ragazzi negli ultimi venti anni in Italia e di evidenziare le scelte tematiche e stilistiche operate da autori e illustratori impegnati nel racconto della vita di un simbolo della cultura latinoamericana, espressione di resilienza, anticonformismo e emancipazione.
Clémence Zamora Cruz, o París para seguir viva: entre esperanzas y desilusiones.
Authors: Brouardelle Nadia
Published: December 2022

Nacida en 1975 en Puebla, en México, la vida de Clémence Zamora Cruz se truncó cuando, con tan sólo 6 años, anunció a sus padres que se quería casar con su profesor de inglés. Una confesión que trastornó su devenir, ya que tuvo que abandonar el domicilio familiar, un domicilio teñido de transfobia. El ambiente exterior, más cruel aún que el hogar familiar, le hizo darse cuenta de la vulnerabilidad de las personas de su condición. El acoso verbal y físico sufrido se hizo efectivo tanto en la escuela como en la calle con la represión policial. Con 15 años decidió abandonar su casa; pasó un año en la calle y fue rescatada por su abuela que, sin entenderla realmente, le enseñó algunos mecanismos de supervivencia para hacer frente a la homo-transfobia reinante en la calle. Finalmente, dio el paso transatlántico para exiliarse en París con la ayuda de un novio francés que tenía en aquel entonces. Una experiencia personal que refleja la vida de miles de transgénero en América Latina que nos gustaría exponer a lo largo de este artículo, gracias también al testimonio vivo de Clémence Zamora Cruz que se ha prestado amablemente a una entrevista virtual. Sus palabras nos testimonian que la situación de los personas transgénero está todavía muy lejos de su deseable inclusión en la sociedad mejicana del siglo XXI.
Ser mujer mayor y habitar la ciudad en América Latina. Una revisión situada y crítica.
Authors: Brito Pacheco Jennifer Diana , Mansilla Sepúlveda Juan
Published: December 2022

El manuscrito estudia las categorías de género y edad en las ciudades latinoamericanas a partir perspectivas teóricas provenientes de la gerontología, geografía y urbanismo feminista. Así, presenta las implicancias de habitar la ciudad desde el ser mujer, la feminización del envejecimiento y la etapa de la vejez, temática relevante y contingente asociada al incremento de las tasas de longevidad. Sin embargo, vivir más revela las diferencias ineludibles de dicho proceso entre hombres y mujeres, junto a las desigualdades acumuladas en los cursos de vida de estas últimas. Estos se presentan en un espectro entre las oportunidades o barreras a la participación y desarrollo de sus vejeces. El método corresponde a una revisión de literatura y tiene como propósito conocer cómo las categorías de género y edad se presentan en los espacios urbanos de las sociedades latinoamericanas. Los principales hallazgos encontrados versan sobre las implicancias socioculturales del género y la edad, las múltiples desigualdades que viven muchas mujeres en las ciudades a lo largo de su vida y que se incrementan en la vejez, el impacto del Covid-19 en sus espacios cotidianos e intenta aportar con miradas reflexivas compartidas desde el feminismo y la interseccionalidad.
La reflexión del teatro sobre la obra Molière realizada por MaZhenghong.
Authors: Luo Wanruo
Published: December 2022

Este artículo pretende abordar la interpretación que la directora china Ma Zhenghong realizó en 2008, en Pekín, de la obra de la autora mexicana Sabina Berman Molière, texto que plantea la relación conflictiva entre las dos máscaras del teatro, la comedia y la tragedia, encarnadas en las figuras de dos dramaturgos del teatro clásico francés, Molière, que da título a la obra, y Racine, el máximo exponente del estilo trágico en la Francia del siglo XVII. Mi propósito es establecer una reflexión sobre la mirada que una creadora teatral china tiene de un tema occidental, que, sin embargo, se suele contemplar como universal y, paralelamente estudiar el modelo tan particular de su puesta en escena, así como su posible repercusión en el contexto teatral pequinés de la época.
Pamięć i dziedzictwo kulturowe: Studia i szkice in memoriam profesor Andrzej Pankowicz (1950-2011)
Authors: Plichta Paweł
Published: December 2022

Zakres semantyczny terminu „dziedzictwo” (heritage) zarówno w języku potocznym, jak i w dyskursie naukowym jest współcześnie wciąż poszerzany. To pojęcie staje się kategorią opisu rzeczywistości przy zastosowaniu metod różnych dyscyplin. Studia nad dziedzictwem (heritology) integrują badaczy zabytków i dóbr kultury, języka, społeczeństwa, tradycji, historii, religii, pamięci społecznej, miejsc zarówno pamięci, jak i niepamięci. Jako ideę wiążącą wiele perspektyw nauk humanistycznych i społecznych zaproponowano różne wymiary pamięci i dziedzictwa kulturowego – tak, by bezpośrednio lub pośrednio stanowiły przykład obecności „przeszłości w teraźniejszości”. Przedstawione ujęcie stanowi nawiązanie do jednego z ostatnich dużych interdyscyplinarnych przedsięwzięć naukowo- -badawczych zainicjowanych przez Profesora Andrzeja Pankowicza, które nosiło tytuł „Przeszłość we współczesnej narracji kulturowej” – i jego poszerzenie. W niniejszym tomie znalazły się studia i szkice, które stanowią rozwinięcie badań o różnym zakresie: lokalnym, narodowym, regionalnym i globalnym, pogłębienie inspiracji powstałych do pewnego stopnia dzięki różnego rodzaju kontaktom z Profesorem: dyskusjom, seminariom, wykładom i współpracy z Nim zarówno w salach wykładowych Uniwersytetu Jagiellońskiego, jak i w ramach Związku Harcerstwa Polskiego czy Polskiego Czerwonego Krzyża.
Prekursorzy historiografii harcerskiej: Wacław Błażejewski, Ewa Grodecka i Władysław Nekrasz
Authors: Massalski Adam
Published: December 2022

The article is an attempt to answer the question on the authors who could be considered precursors of scout historiography. It was assumed that these should be people presenting the history of the organization in a broader than local territorial dimension, as well as showing a relatively analytically and comprehensively important period in its history. These criteria are met by three people whose biographies and achievements have been characterized in the article: Wacław Błażejewski, Ewa Grodecka and Władysław Nekrasz.
Współczesna interpretacja definicji dobra kulturalnego w międzynarodowym prawie humanitarnym
Authors: Marcinko Marcin
Published: December 2022

The definition of cultural property, contained in the Hague Convention for the Protection of Cultural Property in the Event of Armed Conflict of 1954, has been subjected to various interpretations many times since the entry into force of this Convention. Attempts were made to explain and specify such words and phrases as “spiritual heritage”, “cultural heritage” (both tangible and intangible) and “great importance to the cultural heritage”. The solutions developed in this interpretative process helped to solve many problems that had an impact on the respect and protection of cultural property in various regions of the world. These solutions are also of significant importance in contemporary armed conflicts, where attacks on cultural property are often deliberate actions aimed at blurring the cultural identity and cultural heritage of entire communities. Therefore, in order to preserve the cultural heritage of all mankind, which is made up of the heritage of individual nations, the concept of “cultural property” should be interpreted as broadly as possible, taking into account the importance of a given property not only for the culture of particular States, but also globally.
Jak uczyć dziś prawa konstytucyjnego? Refleksje dydaktyczne
Authors: Czarny Piotr , Naleziński Bogumił
Published: December 2022

Teaching constitutional law in times of a serious state system crisis poses particular challenges to lecturers and raises additional problems. This applies to both to courses offered in university law programmes and training courses taught as part of attorney-at-law apprenticeship. The source of difficulties is the controversy related to the composition and functioning of the Constitutional Tribunal and the consequences of its rulings, the complicated relationship between Polish law and European Union law, or the manner in which the Polish authorities have acted during the state of pandemic, and in the context of the crisis on the Polish eastern border. The situation calls for a discussion of the manner in which the above-mentioned issues are to be presented in class, or the extent to which the causes of the crisis or the lecturer’s own assessment of them are to be discussed.
Egzekucja sądowa z tzw. corpora mechanica
Authors: Jasińska Katarzyna
Published: December 2022

The current copyright regulations do not refer to the problem of the judicial enforcement of the so-called corpora mechanica, i.e. objects in which a work has been preserved and which are used to multiply the work, such as a matrix or a negative. In particular, Article 18 of the Copyright Law, which introduces significant limitations on execution against economic rights, does not exclude execution against these objects. However, the lack of regulations does not mean that the issue does not raise any concerns and may be completely detached from copyright issues. The aim of the article is to analyse the relation between the provisions of the Copyright Law and the provisions of the Code of Civil Procedure regarding execution against movable property, with particular emphasis on the following issues: • execution against so-called corpora mechanica and the right to decide on the first release to the public; • execution against copies of the work and the exhaustion of the law; • execution against the original work of art and the entitlement to the droit de suite.
Godność urzędu sędziego z perspektywy instytucjonalnej ochrony dóbr osobistych
Authors: Krok Michał
Published: December 2022

The article describes the issue of protecting the dignity of the judicial office. The dignity of the judicial office can be seen and analysed as a personal interest protected by civil law. In Polish jurisprudence, there is a discussion about two different notions of the protection of personal interests. One is defined as the “concept of subjective personal rights”, and the other as the “concept of institutional protection of personal interests”. According to the former, personal interests are comparable to property rights (erga omnes). Institutional protection of personal interests, on the other hand, refers to the idea of social institutions as structures of rules and norms devised by humans that shape and constrain individual behaviour. Personal interests are protected as an attribute of the human being by legal norms and social patterns of behaviour. The protection of the dignity of the judicial office by legal norms and social patterns of behaviour that take into account the status of judges in society allows the judge’s dignity to be recognized as a personal interest.
Pełnomocnik procesowy powoda – dyrektora Miejskiego Ośrodka Pomocy Społecznej w Krakowie, w sprawach z art. 38 Ustawy o wspieraniu rodziny i pieczy zastępczej oraz konsekwencje braku jego należytego umocowania
Authors: Malczyk Małgorzata
Published: December 2022

The article concerns legal representation of the head of a district family support centre (Powiatowe Centrum Pomocy Rodzinie, PCPR) or the head of a municipal social welfare centre (Miejski Ośrodek Pomocy Społecznej, MOPS) obliged to finance the stay of a child in foster care, in a lawsuit over alimony recovery for a child placed in foster care. The focus is on problems concerning entities entitled to be a legal representative of the head of a PCPR or a MOPS in civil court proceedings, in cases of alimony recovery, and the consequences of insufficient authorization of the representative in such cases.
Roszczenia wynikające z przestępstw przeciwko wolności seksualnej
Authors: Mróz-Krysta Dominika
Published: December 2022

The sexual freedom of the human being deserves exceptional statutory protection. A crime against sexual freedom should not only guarantee that a penal action is undertaken, but also that the injured party receives sufficient compensation for the loss and damage suffered. The interpretation of law concerning the extent of damage, the compensation claim, as well as the limitation applicable to compensation claims for damage suffered as a result of a crime should take into consideration the importance of the violated good and the necessity to protect the injured party.
Dodatkowy objaw nieostrości systemu prawa w koncepcji Jerzego Wróblewskiego
Authors: Pogorzelski Oskar
Published: December 2022

An additional symptom of the fuzziness of the legal system in Jerzy Wróblewski’s concept. The article presents the main assumptions behind the concept of fuzziness of the legal system proposed by Jerzy Wróblewski. Then, an additional symptom of the fuzziness of the legal system will be reconstructed which the author of the idea omitted. Bearing in mind that some of its norms are principles, the legal system is beginning to face problems. Norms that conflict with each other cause the system to “burst”. When writing about the legal system, Wróblewski consistently used the term “legal rule” instead of “legal norm”. The distinction between rules and principles of law reveals itself in conflict-of-law situations, emphasizes the fuzziness of the legal system, and also introduces a kind of uncertainty in the application of law caused by the need to weigh the principles in conflict, taking into account a given a factual state.
Opodatkowanie restrukturyzacji podmiotów gospodarczych – walka ze zjawiskiem unikania opodatkowania czy ze zjawiskiem restrukturyzacji spółek?
Authors: Pustuł Jowita
Published: December 2022

Companies undertaking corporate restructuring transactions should be guaranteed tax neutrality if their actions are justified from the business point of view. Until recently, tax neutrality for most mergers, demergers, transfers of assets and exchanges of shares was almost certain if there were business reasons for it. The conditions for recognizing these operations as tax neutral have changed. As part of the Polish Deal, a new law came into force on 1 January 2022, amending the CIT and PIT Acts. Consequently, only the first exchange of shares can be treated as tax neutral, whereas the neutrality of mergers and demergers is to depend on whether the shares in the acquired or divided entity were acquired as a result of an exchange of shares or another merger or demerger, etc. The purpose of this article is to discuss the latest changes in taxation of company restructurization, including mergers, demergers, transfers of assets and exchanges of shares.
Wrogie przejęcie w warunkach polskiego rynku kapitałowego – ujęcie empiryczne. Wstępne wyniki analiz (lata 2008-2015)
Authors: Regucki Tomasz
Published: December 2022

The paper presents the results of a comprehensive examination of hostile takeovers in Poland, including a legal analysis, a case study and statistical research. It is shown that while they are less common than friendly transactions, hostile takeovers do take place, with their proportion estimated at above 7%. Moreover, even though concentrated ownership structures are dominant in Poland, there is a significant number of companies which, due to their shareholding composition, could hypothetically be a target. The study also indicates that the target companies were characterized by sound financial condition and that the reasons for takeover attempts were the attractiveness of the target, synergy, or empire building, with no evidence for the disciplining corporate governance mechanism. Lastly, it is argued that, due to certain features of Polish company law, the possibility to apply some of the recognized defence strategies against takeovers is limited, which is further reflected in the case study.
Konsument na internetowej platformie handlowej
Authors: Rogoń Dominika
Published: December 2022

The aim of the article is to discuss the key regulations applicable to the sale of goods and services to consumers on online trading platforms, in the light of changes in Polish law resulting from the implementation of Directive 2019/2161 (the Omnibus Directive), Directive 2019/770 (the Digital Content Directive) and Directive 2019/771 (the Sale of Goods Directive). The new regulations are first of all aimed at eliminating the risk factors to which the consumer is exposed as a buyer on the online marketplace, in particular by being misled about the contracting party or by manipulation of offers or prices. Once the changes come into force, entrepreneurs will be obliged, inter alia, to inform the consumer: on the main parameters determining the ranking of products on the platform, about the status of the seller, where applicable – how the obligations related to the contract are shared between the seller and the provider of the online marketplace, where applicable – about personalised pricing based on automated decision-making, and about the actual price reduction in the case of goods on special offer. The new regulations, including the provisions of Regulation 2019/1150 (P2B – platform to business), will create a coherent system to protect the transparency and fairness of the operation of online trading platforms.
Konstytucyjne prawo własności w postępowaniu administracyjnym – art. 155 KPA w praktyce
Authors: Romanowska Magdalena
Published: December 2022

There is often a need to amend final administrative decisions of expropriation due to their irregularities noticed only by legal successors. As a rule, the owner (inheritor) should benefit from protection of property guaranteed by the Constitution of the Republic of Poland. What is more, the Basic Law of the state, defines this protection very broadly, indicating only one source of law which may limit it, and it is only the statute. Meanwhile, the inheritor is not in a position to effectively apply for an amendment under Article 155 of the Code of Administrative Procedure of a final decision of expropriation addressed to the testator. This is due to the nonstatutory obligation formulated by public administration bodies, as well as administrative courts, to maintain the subject and object identity of both expropriation proceedings and those instituted under Article 155 of the Code of Administrative Procedure. In addition, the application of this extraordinary procedure is being limited only to non-discretionary decisions, which is not justified by the content of this provision.
Uczyć się, aby być. W środowisku VUCA. Rozważania o doskonaleniu zawodowym radców prawnych
Authors: Sala-Szczypiński Marcin
Published: December 2022

The author deals with the issue of the implementation of the obligation of professional learning of attorneys-at-law, which is a juridically complicated issue and important from the point of view of practicing the profession of a attorney-at-law and its image. The author undertakes the task of proving that, under the applicable law, there is no possibility of disciplinary punishment of attorneys-at-law for failure to comply with the learning obligation in the manner specified in the Regulations. Disciplinary liability in this respect is excluded, on the one hand, due to the lack of a statutory provision introducing a learning obligation, which would be supplemented by the Improvement Regulations, and on the other, due to the impossibility of recognizing Art. 14 sec. 2 of the Code of Ethics of the Attorney-at-Law (Attorneys-at-law is obliged to participate in professional training on the terms specified by the competent self-government body). The lack of a statutory provision introducing the learning obligation is a consequence of the oversight of the legislator, who officially amended the Act on Legal Advisers for this very purpose, listing the possibility of adopting regulations for professional learning in order to sanction the implementation of this obligation within the scope of activities of the National Council of Legal Advisers.
Juryści rzymscy. Niedościgniony wzór współczesnych prawników?
Authors: Szeląg Tomasz
Published: December 2022

This outline tries to bring the reader closer to the figures of Roman jurists – people who created and perfected the system of Roman law. Who exactly were they? Are they an unattainable ideal for today’s lawyers, or a kind of cliché that should definitely be avoided? Is it possible to compare Roman jurists with modern lawyers at all? And if so, what about the Roman advocati or pragmatici? Therefore, this article aims to present the history of the jurist’s “profession”, its role in the process of shaping and explaining the law, and examples of conduct worthy of following, but also to indicate the basic differences which make it impossible to equate today’s lawyers with Roman jurists without reflection also because of the complicated and very unique system of legal professions in Rome. Roman jurists (i.e. lawyers, experts in law) undoubtedly originated the science of law by taking it over from priests who had had a full monopoly on explaining and interpreting the law. The method developed by jurists has become a canon of legal reasoning that is largely used today.