bluuebunny/crossref_metadata_2025 huggingface dataset:
Эффекты оригинальных соединений ГСБ-106, ГМЛ-3 и ГЗК-111 на экспериментальной модели ангедонии, индуцированной липополисахаридом
Authors: Таллерова Анна Вадимовна , Межлумян А. Г. , Яркова М. А. , Гудашева Т. А. , Середенин С. Б.
Published: March 2021

Ранее в НИИ фармакологии имени В. В. Закусована экспериментальных моделях депрессивно-подобного состояния, вызванного неустранимым стрессом, выявлены антидепрессивные свойства оригинальных соединений: ГСБ-106 (гексаметилендиамид бис(N-моносукцинил-L-серил-L-лизина)) — миметика 4-й петли мозгового нейротрофического фактора (BDNF); ГМЛ-3 (N-бутил-N-метил-1-фенилпирроло[1,2-a]пиразин-3-карбоксамид) — лиганда 18 кДа транслокаторного белка (TSPO), и ГЗК-111 (этиловый эфир N-фенилацетилглицил-L-пролина) — линейного замещённого дипептида, биотрансформирующегося в нейропептид цикло-L-пролилглицин, обладающий влиянием на AMPA-рецепторы. В настоящем исследовании антидепрессивные свойства соединений ГСБ-106, ГМЛ-3 и ГЗК-111 изучены на «воспалительной» модели депрессивного состояния, индуцированного липополисахаридом (ЛПС) у мышей-самцов линии C57Bl/6 с оценкой ангедонии по потреблению раствора сахарозы. ЛПС в однократной дозе 0,5 мг/кг внутрибрюшинно (в/б) вызывал выраженное снижение потребления 1 % раствора сахара по сравнению с контрольной группой на 39 % (p ≤ 0,01). Соединение ГСБ-106, введённое в дозе 0,5 мг/кг внутрь через 24 ч после ЛПС, увеличивало сниженное под действием ЛПС потребление сахара у мышей на 20 % (p ≤ 0,05). Соединение ГМЛ-3 в дозах 0,5 и 1,0 мг/кг однократно внутрь способствовало увеличению потребления сахара на 29 и 21 % (p ≤ 0,01), соответственно. Соединение ГЗК-111 в дозе 1,0 мг/кг однократно в/б способствовало увеличению потребления сахара на 17 % (p ≤ 0,05). Полученные данные подтверждают антидепрессивные свойства соединений ГСБ-106, ГМЛ-3 и ГЗК-111.
Синтез метаболитов бета2-агонистов 2-(4-амино-3,5-дихлорфенил)-2-(алкиламино)этанолов и их выведение с мочой в сравнении с исходными соединениями
Authors: Глушкова Мария Александровна , Попков Сергей Владимирович , Марцынкевич Андрей Михайлович , Бурдейный Максим Львович
Published: March 2021

Синтезированы метаболиты β2-агонистов 2-(4-амино-3,5-дихлорфенил)-2-(алкиламино)этанолов – производные гиппуровой и миндальной кислот. В опытах на крысах изучен профиль экскреции целевых соединений и метаболитов с мочой. После однократного перорального введения соединений в дозах 270 и 540 мкг/кг в неизменном виде удалось выделить 9,7 % 2-(4-амино-3,5-дихлорфенил)-2-(изопропиламино)этанола и 0,7 % 2-(4-амино-3,5-дихлорфенил)-2-(трет-амиламино)этанола от введенной дозы. Установлено время определения целевых компонентов и метаболитов в моче лабораторных животных при чувствительности метода 0,1 нг/мл: 2-(4-амино-3,5-дихлорфенил)-2-(изопропиламино)этанол идентифицируется более 120 ч после приема препарата, 2-(4-амино-3,5-дихлорфенил)-2-(трет-амиламино)этанол — 96 ч. Метаболит 2-(4-амино-3,5-дихлорфенил)-2-(трет-амиламино)этанола, производное гиппуровой кислоты, детектируется в моче дольше, чем исходное соединение — более 120 ч.
Фитохимическая характеристика травы Astragalus vulpinus Willd. и психомодулирующая активность экстракта на его основе
Authors: Самотруева Марина Александровна , Мажитова Марина Владимировна , Сергалиева Мариям Утежановна , Ясенявская Анна Леонидовна
Published: March 2021

Исследован качественный и количественный химический состав экстракта травы Астрагала лисьего (Astragalus vulpinus Willd.); доказано наличие сапонинов, флавоноидов и аскорбиновой кислоты. На белых беспородных крысах-самцах, подверженных информационному стрессу, было изучено психомодулирующее действие экстракта травы Астрагала лисьего на основе оценки поведения животных в тесте «Порсолт». Установлено, что в условиях информационного стресса экстракт травы Астрагала лисьего проявляет протекторное действие, восстанавливая изменения психоэмоционального статуса.
Количественное определение суммы флавоноидов в цветках бархатцев отклоненных
Authors: Куркина Анна Владимировна , Савельева Анна Евгеньевна , Куркин Владимир Александрович
Published: March 2021

Бархатцы отклонённые (Tagetes patula L.) являются ценным источником биологически активных соединений, в том числе флавоноидов. В ходе настоящих исследований разработана методика количественного определения суммы флавоноидов в цветках бархатцев отклоненных методом дифференциальной спектрофотометрии с использованием стандартного образца патулитрина (7-О-β-D-глюкопиранозид 3,5,7,3’,4’-пентагидрокси-6-метоксифлавона) при аналитической длине волны 428 нм. Ошибка единичного определения суммы флавоноидов в цветках бархатцев отклоненных с доверительной вероятностью 95 % составляет ± 3,86 %. Содержание суммы флавоноидов в цветках бархатцев отклоненных варьирует от 6,12 ± 0,07 % до 8,30 ± 0,12 %.
Зависимость кинетики высвобождения растворов химических соединений из гидрофобизированных наноструктурных соединений кремния от поверхностного натяжения жидкости
Authors: Белогорлов Антон А. , Хребтов Д. С. , Бортникова С. А. , Шимановский Н. Л.
Published: March 2021

В настоящей работе исследована кинетика вытекания водных растворов н-пропанола как модельных жидкостей из гидрофобизированного нанопористого материала Silicagel 60 C8. Показано влияние поверхностного натяжения раствора на гистерезис давлений заполнения — вытекания и скорость вытекания. Использование веществ, изменяющих поверхностное натяжение закачиваемого раствора, в частности, доксорубицина, позволяет контролировать процесс релаксации (высвобождения) молекул доксорубицина в очаге заболевания с оптимальной скоростью. Полученные результаты могут быть использованы при создании систем доставки лекарственных средств с помощью наночастиц кремния.
Количественное определение субстанции ангипур в плазме крови методом ВЭЖХ с флуоресцентной детекцией
Authors: Смирнова Людмила Андреевна , Рябуха Анна Федоровна , Абрамов Олег Константинович , Кучерявенко Аида Фатиховна , Спасов Александр Алексеевич , Халиуллин Феркат Адельзянович
Published: March 2021

В статье представлены результаты разработки и валидации метода количественного определения с использованием ВЭЖХ производного ксантина 3-метил-8-(пиперазин-1-ил)-7-(тиетан-3-ил)-1-этил-1H-пурин-2,6(3H,7H)-диона гидрохлорида — субстанции Ангипур в плазме крови доноров. Оптимальными условиями количественного определения субстанции Ангипур являются следующие: буферная система 50 мМ однозамещенный фосфат калия, pH 6,5; соотношение водной и органической фазы 55:45 % об., с добавлением модификатора фазы натриевой соли гептансульфоновой кислоты (0,15 %); температурный режим 40 °C; длина волны экстинкции 290 нм, длина волны эмиссии 340 нм. Чувствительность метода (предел обнаружения) для изучаемого соединения составляет 2,5 нг/мл, предел количественного определения — 5 нг/мл. Средняя ошибка измерения не превышает 15 %.
Синтез, антиагрегационная и антикоагуляционная активность новых N-моно- и N,N-диалкилированных производных имидазола
Authors: Гуревич Константин Георгиевич , Ураков Александр Ливиевич , Басанцев Антон Владимирович , Самородов Александр Владимирович , Данилин Андрей Александрович , Пурыгин Петр Петрович , Кленова Наталья Анатольевна , Баширов Ильнур Ирекович , Баширова Линара Ирековна , Голованов Александр Александрович , Корунас Владислав Игоревич , Липатов Данила Олегович
Published: March 2021

В настоящее время существует ряд эффективных синтетических методов, позволяющих получать различные N-моно- и N,N-диалкилированные производные имидазола, обладающие весьма широким спектром биологической активности, в том числе антиагрегационным и антикоагуляционным действием. В ходе данной работы было осуществлено N-моно- и N,N-диалкилирование 2-метил-, 2-этил- и 4-нитроимидазолов с использованием (адамантил-1)бромметилкетона. Идентификация вновь синтезированных веществ проводилась на основании результатов элементного анализа, ЯМР 1Н и ИК-спектроскопии. Лабораторные исследования, проведенные с изолированной кровью здоровых добровольцев, выявили 5 соединений, проявляющих антиагрегантные свойства. Эти соединения оказывали антиагрегационный эффект, сравнимый по влиянию на максимальную амплитуду агрегации с ацетилсалициловой кислотой и превосходящий его по времени ингибирования реакции высвобождения тромбоцитов.
Our pale blue dot - are there other homes for us in our galaxy?
Authors: Walker Robert
Published: March 2021

Carl Sagan proposed that aggressive galactic imperialism is intrinsically unstable to the point that civilizations disposed that way never spread far through the galaxy. He suggested that by the time civilizations advance as far as interstellar exploration they are pre-adapted to mutual respect. We introduce the idea of galaxy protection as an extension of planetary protection, that advanced civilizations need to develop ways to live sustainably on their planet, as we are doing, and that in the process they also develop an understanding of the need to protect their planets and their entire galaxy from themselves to explore it sustainably with minimal impact on other civilizations and on themselves. Development of attitudes of sustainability and planetary and galaxy protection may be part of an inevitable progression of advanced civilizations as they mature.
Sustainability and the blessing and curse of the observer
Authors: Le Tri Tam
Published: March 2021

I briefly present some points about sustainability from the perspective of epistemology.
Simple Example of a Compact NonHausdorff Space with Closed Singletons
Authors: Chou Yu-Lin
Published: March 2021

We give as a main message a simple but "finer'' example of a compact nonHausdorff space where every singleton is closed.
ERRFI1 is differentially expressed in lymph node metastasis in human breast cancer.
Authors: Mamoor Shahan
Published: March 2021

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). Between the breast and the brain reside the secondary lymphoid organ, the lymph nodes. We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with metastasis to the lymph nodes in humans with metastatic breast cancer. We found that ERBB receptor feedback inhibitor 1, ERRFI1, was among the genes whose expression was most different in the lymph node metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. Analysis of a separate microarray dataset revealed that ERRFI1 was also differentially expressed in brain metastatic tissues. ERRFI1 mRNA was present at decreased quantities in lymph node metastases as compared to primary tumors of the breast. Importantly, expression of ERRFI1 in primary tumors of the breast was correlated with patient overall survival, in lymph node negative patients but not in lymph node positive patients. Modulation of ERRFI1 expression may be relevant to the biology by which tumor cells metastasize from the breast to the lymph nodes and the brain in humans with metastatic breast cancer.
Vector space over a field
Authors: Lobo Matheus Pereira
Published: March 2021

VECTOR SPACE OVER A FIELD and its underlying definitions are presented in this white paper (knowledge base).
Asuhan Keperawatan Jiwa Dengan Masalah Gangguan Sensori Persepsi : Halusinasi Pada Tn. L Di Jalan Amal Luhur Gang Semar
Authors: Situmeang Kristin
Published: March 2021

Skizofrenia merupakan gangguan jiwa berat yang bersifat kronis, gangguan realitas, gangguan fungsi kognitif serta kesulitan dalam melakukan aktivitas
Language contact within the speaker: Phonetic variation and crosslinguistic influence
Authors: Johnson Khia A. , Babel Molly
Published: March 2021

A recent model of sound change posits that the direction of change is determined, at least in part, by the distribution of variation within speech communities (Harrington, Kleber, Reubold, Schiel, & Stevens, 2018; Harrington & Schiel, 2017). We explore this model in the context of bilingual speech, asking whether the less variable language constrains phonetic variation in the more variable language, using a corpus of spontaneous speech from early Cantonese-English bilinguals (Johnson, Babel, Fong, & Yiu, 2020). As predicted, given the phonetic distributions of stop obstruents in Cantonese compared to English, intervocalic English /b d g/ were produced with less voicing for Cantonese-English bilinguals and word-final English /t k/ were more likely to be unreleased compared to spontaneous speech from two monolingual English control corpora (Pitt, Johnson, Hume, Kiesling, & Raymond, 2005; Swan, 2016). Cantonese phonology is more gradient in terms of voicing initial obstruents (Clumeck, Barton, Macken, & Huntington, 1981; W. Y. P. Wong, 2006) than permitting releases of final obstruents, which is categorically prohibited Bauer & Benedict (2011); Khouw & Ciocca (2006). Neither Cantonese-English bilingual initial voicing nor word-final stop release patterns were significantly impacted by language mode. These results provide evidence that the phonetic variation in crosslinguistically linked categories in bilingual speech is shaped by the distribution of phonetic variation within each language, thus suggesting a mechanistic account for why some segments are more susceptible to cross-language influence than others in studies of mutual influence.
MFAP2 is differentially expressed in lymph node metastasis in human breast cancer.
Authors: Mamoor Shahan
Published: March 2021

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). Between the breast and the brain reside the secondary lymphoid organ, the lymph nodes. We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with metastasis to the lymph nodes in humans with metastatic breast cancer. We found that microfibrillar associated protein 2, MFAP2, was among the genes whose expression was most different in the lymph node metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. MFAP2 mRNA was present at decreased quantities in lymph node metastases as compared to primary tumors of the breast. Modulation of MFAP2 expression may be relevant to the biology by which tumor cells metastasize from the breast to the lymph nodes and the brain in humans with metastatic breast cancer.
Book Chapter 1. Pendahuluan
Authors: UNISI Fakultas Pertanian , Apriyanto Mulono
Published: March 2021

Indonesia kaya akan kearifan lokal bidang pertanian dan pengolahan bahan makanan. Kearifan lokal perlu digali kembali dan disesuaikan dengan kondisi saat ini, karena merupakan bagian dari sistem adaptasi masyarakat yang mengenal lingkungannya sendiri. Penganekaragaman pangan sangat penting untuk menghindari ketergantungan pada suatu jenis bahan makanan, seperti tepung terigu. Dalam rangka pengembangan produk pangan dengan memanfaatkan komoditas lokal bahan segar dapat diproses menjadi berbagai macam olahan, salah satunya pembuatan tepung hingga mendapatkan masa simpan yang lebih lama dibanding bahan segar dari tanaman (Apriyanto et al., 2017; Muharun & Apriyanto, 2014).
Thiên nhiên phía sau những suy nghĩ về môi sinh
Authors: Vuong Quan-Hoang
Published: March 2021

Đây là bản ghi đầu tiên nhằm lưu lại một số hình ảnh đẹp đối với người viết bài về môi trường sống quanh ta. Bất kỳ khi nào có thể, ảnh sẽ được bổ sung thêm ghi chú, ngoài thời gian chụp ảnh. Khi gom được một số lượng ảnh thì lại làm tiếp bản thứ hai. Cứ thế cho tới khi nào hết số lượng ảnh đang được lưu trong máy tính.
LOX is differentially expressed in lymph node metastasis in human breast cancer.
Authors: Mamoor Shahan
Published: March 2021

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). Between the breast and the brain reside the secondary lymphoid organ, the lymph nodes. We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with metastasis to the lymph nodes in humans with metastatic breast cancer. We found that lysyl oxidase, LOX, was among the genes whose expression was most different in the lymph node metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. LOX mRNA was present at decreased quantities in lymph node metastases as compared to primary tumors of the breast. Importantly, expression of LOX in primary tumors of the breast was correlated with patient distant metastasis-free survival, in lymph node positive patients but not in lymph node negative patients. Modulation of LOX expression may be relevant to the biology by which tumor cells metastasize from the breast to the lymph nodes and the brain in humans with metastatic breast cancer.
Effect of the third invariant on the formation of necking instabilities in ductile plates subjected to plane strain tension
Authors: Rodriguez-Martinez Jose , Cazacu Oana , Chandola Nitin , N'souglo Komi Espoir
Published: March 2021

In this paper, we have investigated the effect of the third invariant of the stress deviator on the formation of necking instabilities in isotropic metallic plates subjected to plane strain tension. For that purpose, we have performed finite element calculations and linear stability analysis for initial equivalent strain rates ranging from 10^−4 s−1 to 8 · 10^4 s−1. The plastic behavior of the material has been escribed with the isotropic Drucker yield criterion [11], which depends on both the second and third invariant of the stress deviator, and a parameter c which determines the ratio between the yield stresses in uniaxial tension and in pure shear \sigma_T /\tau_Y . For c = 0, Drucker yield criterion [11] reduces to the von Mises yield criterion [32] while for c = 81/66, the Hershey-Hosford (m = 6) yield criterion [19, 22] is recovered. The results obtained with both finite element calculations and linear stability analysis show the same overall trends and there is also quantitative agreement for most of the loading rates considered. In the quasi-static regime, while the specimen elongation when necking occurs is virtually insensitive to the value of the parameter c, both finite element results and analytical calculations using Considère criterion [10] show that the necking strain increases as the parameter c decreases, bringing out the effect of the third invariant of the stress deviator on the formation of quasi-static necks. In contrast, at high initial equivalent strain rates, when the influence of inertia on the necking process becomes important, both finite element simulations and linear stability analysis show that the effect of the third invariant is reversed, notably for long necking wavelengths, with the specimen elongation when necking occurs increasing as the parameter c increases, and the necking strain decreasing as the parameter c decreases.
The Effectiveness of Locomotion Interfaces Depends on Self-Motion Cues, Environmental Cues, and the Individual
Authors: Kelly Jonathan , Gilbert Stephen B.
Published: March 2021

The proliferation of locomotion interfaces for virtual reality necessitates a framework for predicting and evaluating navigational success. Spatial updating---the process of mentally updating one's self-location during locomotion---is a core component of navigation, is easy to measure, and is sensitive to common elements of locomotion interfaces. This paper highlights three factors that influence spatial updating: body-based self-motion cues, environmental cues, and characteristics of the individual. The concordance framework, which characterizes locomotion interfaces based on agreement between body movement and movement through the environment, serves as a useful starting point for understanding the effectiveness of locomotion interfaces for enabling accurate navigation.
A 21st century cognitive portrait of the Himba, a remote people of Namibia
Authors: Trémolière Bastien , Caparos Serge , Davidoff Jules
Published: March 2021

The present research sketches the cognitive portrait of the Himba, a remote population from Northern Namibia living in a non-industrial society almost completely devoid of modern artifacts. We compared the Himba sample to a French sample, exploring cognitive reflection, moral judgment, cooperative behavior, paranormal beliefs, and happiness. We looked for both differences and similarities across cultures, and for the way cognitive functioning is associated with a range of demographic variables. Results showed some important group differences, with the Himba being more intuitive, more religious, happier, and less utilitarian than the French participants. Further, the predictors of these beliefs and behaviors differed between the two groups. The present results provide additional support to the recent line of research targeting cultural variations and similarities, and call for the need to expand psychology research beyond the Western world.
Evolution of Syntax and Semantics From Psycholinguistic and Neurolinguistic Perspectives
Authors: Gabrić Petar
Published: March 2021

In the present paper, I shall provide a narrative review of selected scientific studies and discussions dealing with the evolution of semantics and syntax. The aim of the present paper is not to provide a complete review. The number of studies and discussions on language evolution has exploded recently and the studies stem from various scientific disciplines, impeding my ability to review and understand the entire literature. The focus of this paper will be on psycholinguistic and neurolinguistic literature which has, however, only sporadically tested hypotheses on language evolution. Independently of this obstacle, I shall search in these studies for potential implications for the evolution of semantics and syntax. The aim of this paper is to acquaint Croatian scientists with the topics of the evolution of semantics and syntax and offer them an interdisciplinary view of different approaches and problems which will provide basic information on the topic to the interested reader.In the second chapter, I shall briefly describe language evolution in the context of contemporary evolutionary sciences and address some studies which putatively show that animals may display both semantic and syntactic behaviors in their communication. In the third chapter, I shall introduce psycholinguistic and neurolinguistic studies which suggest that semantics and syntax are embodied in perceptuo-motor system. In the fourth chapter, I shall portray the protolanguage model of language evolution and the accompanying theory of language fossils.
One dad’s COVID-19 diary 1 year later
Authors: Stoeckel Luke E
Published: March 2021

A dad sat down in March 2020 and started a Google doc to keep a record of resources for friends and family, track the progress of life and the response to the COVID-19 pandemic, and tried to stay sane. This continued for a year.
Mice (Mus musculus) do not perceive emergent Gestalt
Authors: Goto Kazuhiro , Watanabe Hikari
Published: March 2021

We have previously demonstrated that chimpanzees, similar to humans, can discriminate the orientations of a diagonal line better when lines are presented in redundant contexts than alone. In the present study, we examined whether the same redundant context facilitated diagonal-orientation discrimination in mice. Mice were presented one of three simultaneous, diagonal-orientation discrimination tasks: (a) presented alone, (b) presented with the context that resulted in emergent configurations in chimpanzees and humans, and (c) presented with the context not resulting in emergent configurations in chimpanzees or humans. In contrast to the facilitative effect of congruent context in chimpanzees and humans, the identical context did not facilitate the discrimination of the diagonal orientation in mice. This finding suggests that mice, unlike chimpanzees and humans, do not perceive emergent Gestalts.
Absolute vs. relative success: Why overconfidence is an inefficient equilibrium
Authors: Solda Alice , Ke Changxia , von Hippel Bill , Page Lionel
Published: March 2021

Overconfidence is one of the most ubiquitous biases in the social sciences, but the evidenceregarding its overall costs and benefits is mixed. To test the possibility that overconfidence mightyield important relative benefits that offset its absolute costs, we conducted an experiment (N=298university students) in which pairs of participants bargain over the unequal allocation of a prizethat was earned via a joint effort. We manipulated confidence using a binary noisy signal toinvestigate the causal effect of negotiators’ beliefs about their relative contribution on the outcomeof the negotiation. Our results provide evidence that high levels of confidence lead to relativebenefits (how much one earns compared to one’s partner) but absolute costs (how much moneyone receives overall). These results suggest that overconfidence creates an inefficient equilibriumwhereby overconfident negotiators benefit over their partners even as they bring about joint losses.
Archaeometric Analysis on Dūmat al-Jandal Pottery Assemblages - A Focus on the Islamic Corpus
Authors: berardino simona , Loreto Romolo , Tarquini Ombretta , Colapietro Marcello , Macchia Andrea
Published: March 2021

In the framework of the Italian Archaeological Mission in the Kingdom of Saudi Arabia, working atDūmat al-Jandal, a first focus on the Islamic Pottery collected in the excavation of the Islamic corecan be introduced, mainly from the area outside the so-called ‘Umar ibn al-Khattab mosque. In thisexcavation area, a stratigraphic sequence (comprised to between 8 th BC to 19 th AD cent.) wasdefined. We collected several Islamic ware in their own stratigraphic context in one of the mainoases of northern Arabia. One of our intent is to distinguish local production from the importedones and we have identify groups by considering fabric features. In this work we reports theresults of the analysis of XRF and macro-photographs of thick sections of several samplesrepresentative each group.
Penggunaan Metode Techique for Order Preference by Similarity to Ideal Solution (TOPSIS) untuk Evaluasi Kinerja Dosen oleh Mahasiswa (Studi Kasus: STMIK Lombok)
Authors: Fadli Sofiansyah , Zaen Mohammad Taufan Asri
Published: March 2021

In general the lecturers performance evaluation is a routinity of a College institute for improving internal quality on an ongoing basis as well as the improvement of the status of accreditation. Performance evaluation activities specifically lecturer at STMIK Lombok funded on each period, that is the end of each semester, the lecturers assessment process performed by the students. The results of this performance assessment will be use to improve the performance of evaluation material and any lecturer who was elected as a lecturer with the best performance will be given the award. To assist in the assessment process, a system that capable to support the decision of the performance assessment of lecturers needed. The purpose of this research is to evaluate the performance of Lecturers by students at STMIK Lombok. The decision-making process aided by a computerized decision support system in expectation that subjectivity in decision-making can be minimised. Decision support systems can be used as a tool for evaluating the performance of the lecturers, so hopefully it can help the policy makers in decision-making, to get objective information about the performance of lecturers based on specified criteria.
PROTOTIPE SISTEM INFORMASI TUNTUNAN PERJALANAN WISATA DI PROVINSI BALI
Authors: Suputra Putu Gede Hendra
Published: March 2021

E-Tourism is a digital platform that connects all tourism stakeholders, and integrates all tourism activities and makes it easy for all travelers to explore tourism charms by accessing applications without being tied to places and times. In Indonesia especially in Bali the development of E-Tourism can be very good. Many sites are available on the internet to be a medium of information and tourist accommodations booking media. In addition, many government and private sites also play a role in the process of providing tourist information, but these sites can be said to be static and simple. These providers only provide text information without prioritizing responsiveness and interactivity to the users.Responsiveness and interactivity are two issues in today's tourism sites. The existing tourism sites in Indonesia are still lacking in responding to the needs or questions of the users and also the interactive functions on the site are felt to be less than satisfactory. Users are only provided an information in the form of photographs and writings about a tourist attraction. Users never know where places can be visited with approximate time, location recommendations, routes and schedules that adjust to user needs. Refers to the problems,we develop an application that able to give recommendation and guidance of tour in Bali area.The system is made on the main needs that have been defined that the system is able to provide travel recommendations. After testing with black box model, the result of the system has been able to meet the needs of the user and provide travel recommendations in accordance with the needs of the user where the travel time-limited, category of place, place of the beginning of the journey and the final place has been fulfilled. The system has given the suitable recommendations based on the criteria that the user wants.
Analisis Kinerja Protokol Routing AODV Single Path dan Multipath Pada Jaringan IEEE 802.15.4/ ZIGBEE
Authors: Hamidi Muhammad , Ashari Ahmad
Published: March 2021

Routing protocol is used to keep the stabilization of connection. Its connected with the performance was caused good communication when the communication from the source node to the destination node. The main factor of success in routing protocol techniques was quality of service to provide the difference level of service in arraging and giving the traffic service prority in the the network like constant bit rate (CBR) and file transfer protocol (FTP) using wireless network sensor network (WSN).This research will analyse the achivement quality of service in IEEE 802.15.4/Zigbee network used routing protocol techniques ad hoc on demand distance vector (AODV) single path and multipath based on distance and number of nodes simulated used Cygwin software. Based on the results of tests performed using the technique of routing protocol Ad Hoc On Demand Distance Vector single path and multipath for service traffic with constant bit rate and file transfer protocol, the result packet delivery ratio and goodput better on the distance between nodes 10m than the distance between node 15m to 25m, thus indicating that the goodput affect the traffic services are used. And the average delay results using the technique of multipath routing protocol AODV lower, thus indicating that the alternative pathway suppress buffer traffic delay on the service used.
Analisa dan Perbandingan Kinerja Routing Protocol OSPF dan EIGRP dalam Simulasi GNS3
Authors: Loka Gede Andika , Permana Silvester Dian Handy , Bintoro Ketut Bayu Yogha
Published: March 2021

Router is the network equipment for route the packet from one network segment to another in a bigscale network. Router can route packet because there is a routing table in router configuration. Routing table is anaddress list of source and destination address where the packet will be routed. There are two methods of routing tableconfiguration, static routing and dynamic routing. Static routing is a routing table configuration method where all ofrouting table content is configured manually, usually for a small scale of network. Dynamic network is a routing tableconfiguration method by the router automatically, usually for a big scale of network. A dynamic routing is built fromthe routing information collected by the routing algorithm. There are two routing algorithm, link-state and distancevector algorithm. This simulation will be built in GNS3 simulation software. Goal of this research is to compare theperformance between that two algorithm from two routing protocol that using each of those two algorithm. Thecomparison will be running between OSPF routing protocol on the link state routing protocol and EIGRP on thedistance vector routing protocol side. The result of this analysis and comparison of those two routing protocol isexpected to be a reference of choosing better routing protocol in building a network.
Proses Clipping pada Map Game Online RPG menggunakan Algoritma Cohen-Sutherland
Authors: permana silvester dian handy
Published: March 2021

Nowadays, online games is the media for interaction with another people in the world. In this game, players are presented in the virtual world. This virtual world displayed on a graph of realism that have various shapes fact as houses, roads, walls, fences, etc. Players in this online game will also be given an avatar of the identity and the realization of the players in the virtual world. Virtual world in the online RPG game certainly require a lot of graphics realism in the viewport windows virtual but certainly not to display the virtual world as a whole. This is because the views of the players who became avatar certainly made equal to the real-world view of the player. In presenting part of the virtual world certainly requires clipping of the map which is a manifestation of the virtual world. Clipping technique used to use Cohen-Sutherland algorithm. This algorithm makes clipping as nine areas where the viewport window will be the main focus in the map and displayed on the screen viewport. This would blur the eight other areas that cannot be seen directly in the viewport. This study provides a view of the same players as in the real world that is played online games can provide a real experience to his players.
Simulasi Perangkat Lunak Alat Pengeruk Sampah Otomatis Menggunakan Logika Fuzzy Mamdani
Authors: Saputra Gusti
Published: March 2021

The garbage crusher is one of the tools that is considered to have a high level of effectiveness in overcoming the problem of garbage in the river around DKI Jakarta. However, the dredging tool that is currently available is still moving manually in operation, which results in scheduling human resources that are less than optimal in every operation. This requires a garbage dredger whose operation can work automatically so that the scheduling of human resources in the operation of the garbage crusher is optimal. In this research, automatic garbage scrapers will be simulated using a Fuzzy Inference System. Simulation in the form of knowledge making on decisions that will later be on automatic garbage scrapers using a fuzzy inference system.
Monitoring Cairan Infus Secara Realtime
Authors: Hidayati Kurnia , Barwaqah Rico Basyar
Published: March 2021

At present, many are found in a hospital, the number of inpatients is not balanced with the number of medical staff, especially in the nursing service on duty 24 hours to monitor the patient's condition one by one. As a result of these limitations, the possibility of negligence of the guard officer is very possible, especially in monitoring the condition of infusion fluids in patients. In the task of monitoring the condition of the patient's intravenous fluids, nurses usually have to go back and forth and check the condition of the infusion manually at any time that has been previously estimated. On the basis of this reality, in this final assignment a monitoring system for intravenous fluids was made in real time and centrally that can control the infusion fluid volume of patients based on ATMEGA32 microcontroller with proportional-derivative control method and can provide information about the condition of the patient's actual infusion fluid to medical personnel or guard officers centrally using cables that reconnected and function as a means of communication between the microcontroller and the computer. This tool uses a light sensor to detect the height of the infusion fluid and convert it to liquid volume at ATMEGA 32. If the liquid reaches the minimum volume, then the information from the sensor running or detecting infusion fluid will be processed through a microcontroller and sent to a computer that functions as a monitor or LCD.
Identifikasi Kondisi Pohon Peneduh Terhadap Keselamatan Manusia Menggunakan Logika Fuzzy Mamdani
Authors: Fadhilah Indra Malik Akbar
Published: March 2021

The condition of shade trees is very important for the safety of road users. It often happens in shade trees because of the factors of temperature, climate, air damage, and lack of oxygen in the tree. The purpose of this study is to study the health conditions in shady trees against human safety. So to overcome the problem in this study, a selective felling program in shady trees will bemade using the fuzzy logic method to solve the problem of existing factors by creating variables that will be used in processing on fuzzy logic. The results of this study are to identify which health conditions of trees that are feasible to be cut according to the results of fuzzy logic.
LIDERANÇA E INTELIGÊNCIA CULTURAL: UMA ANÁLISE DA PRODUÇÃO CIENTÍFICA INTERNACIONAL DE 2003 A 2020
Authors: Souza Ana Carolina Martini Braz de Mello e
Published: March 2021

O presente trabalho buscou realizar uma investigação da produção científica internacional sobre os temas liderança e inteligência cultural a partir de um levantamento bibliográfico, filtragem e análise dos resultados apresentados pela base de dados Scopus para as áreas de Administração e Psicologia. A pesquisa se baseou no período de 2003 a 2020 e foram pesquisados artigos publicados em inglês, utilizando-se os termos “cultural intelligence” e “leader*” como parâmetros de busca em “título, resumo e palavras-chave”. Os resultados foram tratados utilizando-se a ferramenta disponibilizada pelo próprio SCOPUS (Analyze Search Results) para conhecimento do panorâma geral do campo científico. Posteriormente foi realizada a leitura analítica para filtragem e limpeza dos dados, o que resultou em uma amostra final de 36 artigos, sobre a qual foi proposta uma categorização das temáticas mais recorrentes identificadas. Com base na delimitação inicial, identificação das categorias e contabilização dos artigos, foi proposta uma agenda de pesquisa futura, que, acredita-se, ter contribuido para a compreensão do tema, reforçando a sua relevância nos estudos organizacionais, apresentando tendências para futuros trabalhos acadêmicos no âmbito dos estudos em Administração e Psicologia Organizacional.
EMPREENDEDORISMO FEMININO: UMA ANÁLISE DESCRITIVA E COMPARATIVA ENTRE ORGANIZAÇÕES ADMINISTRADAS POR MULHERES E POR HOMENS
Authors: Pessotto Ana Paula , Rosa Neimar Ferreira da , Rebonatto Cintia Sonale , Costa Carlos
Published: March 2021

Dado os indicadores socioeconômicos e demográficos da região do Médio Alto Uruguai e a reconhecida contribuição econômica do empreendedorismo feminino para os países em desenvolvimento, este estudo pretende realizar uma análise comparativa dos empreendimentos administrados por mulheres com os administrados por homens na região. Para coleta de dados utilizou-se de dados secundários, onde foram selecionadas aleatóriamente 400 dessas empresas. Os resultados deste estudo permitiram identificar que as mulheres da região são maioria na gestão das empresas e atuam principalmente no segmento comercial, mas ainda empregam menos que as empresas administradas por homens. O estudo contribui com outros focados no empreendedorismo da mulher, com implicações teóricas e práticas, no intuito de estimular a qualificações desses negócios e a garantir a sua sobrevivência.
The Effect of The Blended Learning Model on The Improvement of Student Learning Outcomes
Authors: Badrus Badrus , Arifin Zaenal
Published: March 2021

The purpose of the study was to analyze the effect of the blended learning model towards learning outcomes of the comprehension concepts and economic problems solving of Private Islamic High School students in Nganjuk Regency. The study used an experimental method, with a quasi-nonequivalent control group design. The research was conducted at Private Islamic High School Al Manar Prambon Nganjuk. The samples were conducted based on students' characteristics and similarities in economic topics. The experimental class was assigned to XI Social 1 and the control class was XI Social 2. The analysis technique used was descriptive statistical technique and two-ways MANAVA. Descriptive statistics were seen from the mean, standard deviation, variance, and presentation. The results of the MANAVA test analysis when viewed from the centroid pillar's trace, Wilks' lambda, hotelling's trace, and Roy's lambda root in the experimental class had a significance value of 0.000. The value was transformed to the Fisher distribution or F test, then it is smaller than α ˂ 0.050. The study shows that the blended learning model has an effect on the learning outcomes of comprehension concepts and economic problems solving of Private Islamic High School students.
KAJIAN PENGEMBANGAN KAWASAN CAMPURAN (MIXED USE) DI PERKOTAAN
Authors: MEDTRY Medtry
Published: March 2021

Abstrak

 

Kawasan mixed use pada dasarnya adalah suatu kawasan urban yang dirancang secara terintegrasi (integrated development), dengan kepadatan bangunan yang cukup tinggi dan merupakan kombinasi fungsi lahan yang bersifat campuran (mixed used), dimana kunci terpenting dalam keberhasilannya adalah berjalannya fungsi mekanisme kontrol yang merupakan implementasi dari regulasi-regulasi pengembangan kawasan superblok itu sendiri (Wikipedia, 2018). Pengertian lain berdasarkan arsitag.com   menyebutkan bahwa Mixed use merupakan penggunaan sebuah bangunan, satu kompleks bangunan, atau lingkungan untuk lebih dari satu kegunaan. Konsep ini telah diadopsi oleh beberapa negara di dunia sejak tahun 1920. Idenya adalah untuk menggabungkan kantor, tempat tinggal, dan pusat aktifitas lainnya di area yang berdekatan atau bahkan di gedung yang sama.

Di Indonesia kawasan campuran diperbolehkan dan diatur dalam Peraturan Pemerintah Nomor 15 tahun 2010 tentang Penyelenggaraan Penataan Ruang yang mengamanatkan bahwa untuk meningkatkan kualitas struktur ruang dan pola ruang. Selain itu dalam Peraturan Menteri ATR/BPN Nomor 16 Tahun 2017 tentang Pedoman Pengembangan Kawasan Berorientasi Transit, Peraturan Menteri ATR/BPN Nomor 1 Tahun 2018  tentang Penyusunan Rencanan Tata Ruang Wilayah (RTRW), dan Peraturan Menteri ATR/BPN Nomor 16 Tahun 2018  tentang Penyusunan Rencanan Detail Tata Ruang (RDTR) dan Peraturan Zonasi (PZ.

Dalam peraturan penataan ruang, kawasan campuran diatur dalam zona campuran (C), yang meliputi; perumahan dan perdagangan/jasa, perumahan dan perkantoran, perdagangan/jasa dan perkantoran. Untuk penggunaan kategori zona campuran harus didukung oleh adanya batas zona yang jelas yang dapat membatasi perluasan fungsi campuran lebih lanjut dan harus ada upaya untuk mendorong perkembangan fungsi campuran menuju ke satu zona peruntukan tertentu. Oleh karena itulah perlu dilakukan penelitian ini untuk memberikan masukan dan usulan bagi pihak terkait antara lain tipologi kawasan campuran, prasyarat kawasan campuran, prinsip kawasan campuran, kriteria dan standar kawasan campuran.

 

Kata Kunci: kawasan campuran, tipologi, prasyarat, prinsip, kriteria
Analisis Kelayakan Rencana Pengembangan IKM Kerupuk Jengkol di Sentra IKM Kerupuk, Kecamatan Jayanti, Kabupaten Tangerang
Authors: Mohamad Haifan Haifan
Published: March 2021

Buah jengkol (Archidendron pauciflorum B) adalah salah satu buah yang cukup diminati masyarakat, selain dapat mengundang selera makan, buah jengkol juga memiliki banyak manfaat bagi kesehatan. Salah satu pemanfaatan buah jengkol digunakan sebagai bahan baku pembuatan kerupuk. Permintaan kerupuk jengkol terus meningkat setiap tahunnya, sehingga prospek peluang usahanya cukup bagus. Melihat peluang tersebut, perlu peningkatan kapasitas produksi industri/ Industri Kecil dan Menengah (IKM) kerupuk jengkol untuk memenuhi permintaan masyarakat. Penelitian ini bertujuan melakukan analisis kelayakan rencana pengembangan industri/ IKM kerupuk jengkol di wilayah sentra IKM kerupuk di Kecamatan Jayanti, Kabupaten Tangerang. Metode yang digunakan dalam penelitian ini bersifat diskriptif-kuantitatif. Analisis kelayakan rencana pengembangan IKM kerupuk jengkol meliputi aspek bahan baku, aspek teknologi dan aspek finansial. Dari hasil penelitian didapatkan bahwa ketersediaan bahan baku jengkol untuk mendukung industri/ IKM sangat memadai yang berasal dari wilayah Provinsi Banten, teknologi proses serta mesin dan peralatan sudah tersedia dan dikuasai. Analisis aspek finansial dengan asumsi umur ekonomi usaha selama lima tahun menggunakan suku bunga 9,75 persen memberikan nilai Net Present Value (NPV) positif sebesar Rp 857.492.977; Internal Rate of Return (IRR) sebesar 28,64 persen, Benefit/ Cost (B/C Ratio) sebesar 1,10; Payback Period (PP) selama 2 tahun 6 bulan dan Break Event Point (BEP) sebanyak 154.104 kemasan per tahun. Sementara itu, analisis senstivitas yang dilakukan terjadi kenaikan biaya produksi sebesar lima persen dan penurunan jumlah produksi sebesar lima persen didapat perhitungan usaha yang masih layak untuk dikembangkan.
Aplikasi Lean Manufacturing Pada Proses Produksi Produk Sanitary untuk Peningkatan Efisiensi (Studi Kasus Perusahaan Keramik)
Authors: Sudri Ni Made , Hardiyanto Mohammad , Pratiwi Octasylva Annuridya Rosyidta , Salsabila Kintan
Published: March 2021

Peningkatan efisiensi produk closet pada perusahaan keramik sanitary dengan penerapan lean manufacturing untuk peningkatan persaingan perusahaan. Identifikasi permasalahan ditemukan pemborosan pada proses pembuatan closet yaitu jenis pemborosan dominan inventory (21,81%), overproduction (20,21%) dan motion (18,87%). Penyelesaian jenis pemborosan agar efisiensi proses meningkat dilakukan proses mapping tools untuk penentuan jenis tools yang sesuai dengan masalah dominan, diperoleh adalah process activity mapping (PAM) dan supply chain response matrix (SCRM). Usulan perbaikan yang dapat dilakukan agar efisiensi proses meningkat adalah penambahan alat bantu operator untuk pengurangan waste motion, efisiensi waktu pengeringan dengan penambahan alat pengering bagian bawah storage. Pemborosan inventory dapat diminimalisir dengan penerapan sistem gudang metoda FIFO serta peramalan target produksi untuk atasai overproduction. Peningkatan process cycle efficiency (PCE) diperoleh sebesar 3,15%.
Overview on the Production and Commercialization of “Barreado” in Paraná Coast, Brazil
Authors: Anacleto Adilson , Magno Antonia Oliveira Martins , Oliveira Eduarda Vitória Santos de , Trancoso Gustavo Borba de Souza , Calado Marcos Aurélio Costa
Published: March 2021

Barreado is a typical dish from Paraná, made with beef and some specific spices and cooked for a long time in a clay pot sealed by a mixture of ashes similar to the clay, being this dish produced with greater relevance in the coastal region of the state, where there is the largest productive arrangement of this dish in Brazil and where has a strong gastronomic touristic appeal. Despite the historical, cultural and economic relevance of gastronomic tourism in Paraná, few and sparse studies use the issue, thus, this study aimed to elaborate and show an overview of the current scenario of production and trade of the dish, highlighting the implications and potential of Barreado in Paraná Coast. The survey methodology was based on quantitative and qualitative descriptive exploratory research, the data collection was accomplished between May and June 2020, with 151 consumers.The study revealed that among Barreado consumers there was a predominance of women (n=61.5%). The average age was 40.9 years old, and the majority of the respondents (46.4%) preferred to consume Barreado when it is done by the traditional way of cooking, in a clay pot and on a wood stove for 24 hours. The greatest potential described was the fact that the Barreado is a typical and original product of Paraná and has great acceptance in gastronomic tourism, which reveals its capacity to be a source that drives regional development, however the price considered high and the distribution network in the retail market was classified as deficient, they were identified as limiting factors to the development of the Barreado production and commercialization. In this context, still on the issue of price and its relationship with the consumption, given that it was one of the main factors identified as limiting and the lack of studies on the subject, for further studies on the cost and quality relationship should be considered by researchers in new future studies.