bluuebunny/crossref_metadata_2025 huggingface dataset:
Whole-process management of complications during CAR-T therapy
Authors: Li Yingying , Mei Heng
Published: October 2022

Chimeric antigen receptor T cell (CAR-T) therapy has substantial efficacy in the treatment of relapsed and/or refractory hematological malignancies. However, despite this outstanding performance, various CAR-T complications challenge treatment success during the entire process of CAR-T therapy. Short-term (within 28 days) complications with a high incidence include cytokine release syndrome, immune effector cell-associated neurotoxicity syndrome and CAR-T associated coagulopathy. Many other complications may also occur during mid- (28–100 days) and long-term (>100 days) follow-up. Determining how to identify and standardize the management of adverse events in CAR-T therapy in an accurately and timely manner is crucial for its wide application. This review focuses on time periods after CAR-T cell therapy, and discusses the occurrence and management of adverse events, with an aim to improve the safety management of CAR-T cell therapy.
Parential Alienation in the Polish Legal System
Authors: Helios Joanna , Jedlecka Wioletta
Published: October 2022

The aim of this article is to present an issue that has recently become more and more important in the social and legal discourse, namely parental alienation. This phenomenon is generally only partially regulated in the Polish legal system, hence there are questions about penalizing behavior that manifests itself in counteracting contacts or exercising alternate custody. The aim is to explain the concepts of parental alienation syndrome and parental alienation, to analyze the legal aspects of parental alienation, and to point to the alternate seal as a possibility of preventing cases of parental alienation.
Significance of Family Law Regulations for a Criminal Law Assessment of Neglect
Authors: Sitarz Olga
Published: October 2022

The article addresses the difficult and complicated issue of a legal assessment of neglect by an adult family member of a person vulnerable due to their age or state of health. The analysis carried out in the first part showed that the provisions of the Family and Guardianship Code are indispensable for a criminal law evaluation of such behaviour. Then, the family law regulations were interpreted in terms of the principles of liability envisaged in the Criminal Code. The article pointed to legislative shortcomings of family law that have a certain impact on the application of criminal law.
Parent-Child Contacts in the Presence of Legal Court-Appointed Guardian. Practice in View of the Need for Legislative Change
Authors: Goworko-Składanek Beata , Prymak Tomasz
Published: October 2022

Contact with the child has for years been the subject of deliberations and discussions of entities interested in the welfare of the child, often caught up in the conflict between the parents. They concern, among others, the role of professional guardians/probation officers, whose presence during parent-child contact, according to the law, constitutes one of the forms of court restrictions on this form of maintenance of the parent-child relationship. The aim of the text is an attempt to identify the technical problems associated with the implementation of the court decisions in this matter, and thus to indicate the gross disproportion between the current shape of the regulations on the participation of a guardian in parent-child contact and the needs of practice. Thus, the aim of the study is to engage the community of guardians in the ongoing work on legislative changes and the potential effects of the proposed legislation, including substantive and implementing provisions of family law aimed at the guaranteed right to contact with the child.
Legal Construction of Childhood Vaccinations Against the Background of Polish Law – Remarks De Lege Lata and De Lege Ferenda
Authors: Drozdowska Urszula
Published: October 2022

The subject of the article is a reflection on the legal construction of preventive vaccination in children. Using the dogmatic-legal method and the analysis of case law, the author examines the issues related to the consent of the child’s legal representative and the question of legal sanctions applied in the event of opposition to this medical intervention. The subject of consideration are also potential possibilities of solving the conflict between the child’s legal representative and public authorities (represented by the sanitary inspection authorities). Thus, the issue is to find such a solution that would lead not only to the goal of achieving the so-called herd immunity, but also to the proper protection of the rights of persons in a potential conflict and the realization of the so-called best interests of the child.
The Right of a Child to Contact Relatives in Cross-Border Situations – Comments Based on EU Legal Regulations and the Case Law of the CJEU
Authors: Maliszewska-Nienartowicz Justyna
Published: October 2022

The article presents EU legal regulations and decisions of the Court of Justice of the European Union (CJEU) relating to one of the most important rights of children, which is their right to direct contact with their parents and other people close to them. Difficulties may be encountered in cross-border situations when the child moves to another Member State or to a third country. In the first case, EU regulations apply, in particular Art. 24 of the EU Charter of Fundamental Rights and the Council Regulation 2019/1111. They are complemented by the case law of the CJEU, which interprets the terms they contain, e.g. the right to personal contact with the child. Its decisions recognise the best interests of the child as an overriding principle. At the same time, the Court tries to adapt existing EU legal provisions to social realities related not only to increased mobility, but also to changes in the structure of the family itself (patchwork families, single-parent families, etc.).
Epigenetics, ovarian cell plasticity, and platelet-rich plasma: Mechanistic theories
Authors: Sills E Scott , Wood Samuel H
Published: October 2022

Ovarian platelet-rich plasma (PRP) is claimed to restore the fertility potential by improving reserve, an effect perhaps mediated epigenetically by platelet-discharged regulatory elements rather than gonadotropin-activated G-protein coupled receptors, as with stimulated in vitro fertilization (IVF). The finding that fresh activated platelet releasate includes factors able to promote developmental signaling networks necessary to enable cell pluripotency tends to support this theory. The mechanistic uncertainty of intraovarian PRP notwithstanding, at least two other major challenges confront this controversial intervention. The first challenge is to clarify how perimenopausal ovarian function is reset to levels consistent with ovulation. Perhaps a less obvious secondary problem is to confine this renewal such that any induced recalibration of cellular plasticity is kept within acceptable physiologic bounds. Thus, any ‘drive’ to ovarian rejuvenation must incorporate both accelerator and brake. Ovarian aging may be best viewed as a safeguard against pathologic overgrowth, where senescence operates as an evolved tumor-suppression response. While most ovary cells reach the close of their metabolic life span with low risk for hypertrophy, enhanced lysosomal activity and the proinflammatory ‘senescence-associated secretory phenotype’ usually offsets this advantage over time. But is recovery of ovarian fitness possible, even if only briefly prior to IVF? Alterations in gap junctions, bio-conductive features, and modulation of gene regulatory networks after PRP use in other tissues are discussed here alongside early data reported from reproductive medicine.
Quality of life, distress, anxiety and depression of ambulatory cancer patients receiving chemotherapy
Authors: Papadopoulou Aggeliki , Govina Ourania , Tsatsou Ioanna , Mantzorou Marianna , Mantoudi Alexandra , Tsiou Chrysoula , Adamakidou Theodoula
Published: October 2022

Objective and aim. Cancer and its treatment have substantial physical and psychological consequences that severely affect the patients’ quality of life (QoL) and emotional status. This study aimed to investigate the relationship between distress, anxiety, depression, and QoL of ambulatory cancer patients undergoing chemotherapy.

Methods. A descriptive, cross-sectional study of 150 cancer patients who were receiving chemotherapy in the outpatient unit of a central anticancer hospital in Athens. The data were collected through convenience sampling between November 2017 and January 2018, using a demographic and clinical characteristics questionnaire, the Distress Thermometer (DT) and Problem List (PL), the Hospital Anxiety and Depression Scale (HADS) and the European Organization for Research and Treatment for Cancer QoL assessment Questionnaire (EORTC QLQ-C30).

Results. Variability characterized the sample’s demographic and clinical characteristics. The majority of patients were women (64%), married (66%), high school graduates (43%), had breast cancer (35%), with a mean age of 60.07 ± 11.42. 83% reported anxiety, 75% reported fear, 51% nervousness and sadness, 34% depression and 84.7% fatigue. The DT was positively correlated with HADS (p<0.001) and with almost all EORTC QLQ-C30 functional subscales and symptoms (p<0.001). The HADS-Anxiety was significantly correlated with overall QoL and with almost all the EORTC QLQ-C30 functional scales and symptoms (p<0.001). HADS-Depression was significantly correlated with overall QoL and all the EORTC QLQ-C30 functional scales and symptoms (p<0.001). Women tended to have higher level of distress (p=0.003). There was a statistically significant relationship between educational level, the cognitive functioning scale (p=0.017) and financial difficulties (p=0.026).

Conclusions. Ambulatory cancer patients undergoing chemotherapy are at risk of facing distress in all aspects of daily living, along with anxiety and depression, which decreases their QoL. Oncology nurses as members of multidisciplinary teams should assess the affected aspects of patients’ QoL and appropriate interventions should be implemented at community level.
Oral health, the patient's perspective during the COVID 19 pandemic
Authors: Paun Ariadna Georgiana Eugenia , Chifor Radu , Radu Constantin , Strilciuc Ștefan , Badea Iulia Clara , Borzan Cristina Maria
Published: October 2022

Background and aims. On March 16, 2020, the state of emergency was established with drastic measures of isolation and quarantine. Among the measures taken in the context of the state of emergency was the closure of dental offices throughout the country. The aim of our questionnaire-based cross-sectional study was to identify the psycho-affective implications of the Romanian citizens induced by the COVID-19 pandemic period as well as their opinion related to the self-perceived oral health status during this period.

Methods. An original questionnaire was designed consisting of 41 questions, which were distributed to the general population via the Internet. The first part of the questionnaire investigated the respondents’ opinion regarding the impact of this COVID-19 pandemic period of isolation on their oral health and the attention paid by the subjects to oral hygiene during restrictions. The second part refers to their addressability to the dental services during this pandemic and the third part interrogates different characteristics, namely the presence of comorbidities, possible anxiety, and stress.

Results. A total of 769 participants answered the questionnaire online.

Conclusion. According to their responses most of the respondents were not afraid of the possibility of contracting Sars-Cov-2 during dental treatments, but were in certain periods deprived of accessing dental services due to lockdown restrictions. They are aware of their oral health problems and pay more attention to oral hygiene so that they do not get worse during restrictions.
Design and development of a mixed alcoholic beverage kinetics using asaí (Euterpe precatoria) and copoazú (Theobroma grandiflorum)
Authors: Quintero Mendoza Willian , Díaz-Salcedo Raquel Oriana , Hernández-Gómez María Soledad
Published: October 2022

Copoazú (Theobroma grandiflorum), a fruit from the same genus as cacao, and asaí (Euterpe precatoria) a palm fruit, both of Amazonian origin, could promote local economic growth through fruit processing to increase the added value. This study aimed to identify the kinetics of alcoholic fruit beverages made from copoazú and asaí pulp or seeds, i.e., the fermentation kinetics in the case of copoazú drinks and the diffusion kinetics in the case of asaí drinks. Additionally, the feasibility of generating a milky mixture with the liquor obtained from the copoazú fruit processing was evaluated. Statistical analysis was performed by ANOVA tests and modeling of kinetics parameters with an evolutionary algorithm and optimization. Copoazú pulp was fermented with 15% Prestige Turbo Yeast®. Fermentation was separated into two stages: controlled fermentation during the first 5 d and a maturation process in the following 25 d. According to the modeling, the greatest efficiency was observed with 600 g L-1 pulp concentration and soluble solids adjusted at 35°Brix, with alcohol contents of up to 20% (w/v) after 30 d of processing and evidence that there may be inhibition of fermentation due to glycerol. The whole fruit and pulp of asaí were extracted with ethanol to obtain a liquor with the micronutrients and flavors of the fruit, and the anthocyanin content was used as a degradation process marker. Modelling showed that the optimum point that yielded maximum anthocyanin concentration was achieved at 60 d of maturation by extracting pulp in a 45% (w/v) ethanol solution resulting in a maximum anthocyanin content of 94.2 ± 15.3 mg of cyanidin-3-glucoside kg-1 of liquor. After that, a degradation process was observed as anthocyanin content diminished.
Control of N-NH4+ and K+ leaching in potato using a carrageenan hydrogel
Authors: Puentes Montealegre Nicolás , Santamaría Vanegas Johanna , Ñústez-López Carlos Eduardo , Rozo Gladys
Published: October 2022

Potato cultivation requires fertilizers to sustain crop yields, but a significant percentage of added nutrients is lost by leaching. The use of coating materials for fertilizers is currently being considered to reduce these losses. The objective of this study was to determine if a carrageenin based hydrogel (CBH), used to coat fertilizer, decreases NH4+ and K+ leaching from a potato crop without affecting growth, specific gravity, and tuber yield. The CBH was tested in a diploid potato crop, cultivar Criolla Colombia (Solanum tuberosum L., Phureja Group) using a randomized full block design including the treatments noncoated fertilizer (T1), CBH coated fertilizer (T2), and no fertilizer (T3). Mineral nutrients in soil leachates together with dry biomass, foliar area, chlorophyll, tuber specific gravity, and yield were quantified. The nutrient content in leachates from T2 were below those from T1. No significant differences between treatments were observed for growth factors, yield, and tuber specific gravity. This study confirms the controlling effect of the CBH, ensuring the retention of the nutrients added in the fertilizer and preventing them from easily leaching. Future field studies are worthwhile to establish the amount of fertilizer this coating could save.
Basal rot in carnation (Dianthus caryophyllus L.) is caused by Fusarium verticillioides (Sacc.) Nirenberg
Authors: Filgueira Duarte Juan José , Rincón-Sandoval Cindy Melissa , Quinche Carol Yineth , Soto Johana Carolina , Monroy Ingrid Elizabeth
Published: October 2022

The carnation is one of the most important products for export in the floriculture industry of Colombia. Fusariosis (a disease resulting from presence of Fusarium) appears on the crops in two forms: vascular wilt and basal rot. The first is caused by Fusarium oxysporum f. sp. dianthi, which is a well-characterized disease. The second, caused by Fusarium verticillioides (previously Fusarium roseum), is a non-characterized disease and its development in the plant has not been described in detail. The symptoms of basal rot were differentiated from vascular wilt, through infection of plants in the greenhouse, with isolates of F. verticillioides and F. oxysporum obtained from lesions of symptomatic plants. The fungi morphological characterization allowed differentiation of the isolates of these two species and their growth habits on different media. The sequencing of 8 different genes with more than 13 amplicons in the 2 species showed genetic differences that grouped the isolates into different taxa. Multilocus sequence typing analysis using DNA sequences of 8 different genetic regions confirmed the presence of F. verticillioides. In this study, the role of F. verticillioides was demonstrated in the stems of carnation in commercial crops that presented pathogenic lesions. According to the results of the study, F. verticillioides is the etiological agent that produces the basal rotting in carnation plants, alone or in association with F. oxysporum.
Quality of Butia capitata fruits harvested at different maturity stages
Authors: Martineli Maristella , Castricini Ariane , Oliveira Santos Julia Lavínia , Pereira Loranny Danielle , Maida de Albuquerque Maranhão Camila
Published: October 2022

Butia capitata (Mart.) Becc. or “coquinho azedo” is a native palm species of the Brazilian savannah, bears fruits which are sold fresh or as frozen pulp. This study examined postharvest changes in “coquinho azedo” harvested at a commercially immature stage and later evaluated the quality of these fruits by comparing them with those harvested fully ripe. Fruit purchased in the 2020 harvest in Santo Antônio do Retiro, MG (Brazil), were harvested at different degrees of maturity, namely, commercially immature and ripe, according to the point of harvest adopted in the region. For 7 d, weight loss, skin color and respiratory activity were evaluated in the commercially immature-harvested fruits. At 7 d postharvest, physical and chemical evaluations of the pulp were performed. The ripe-harvested fruits were subjected to the same evaluations, but only at 1 d postharvest. The skin color of commercially immature-harvested fruits tended to yellow over the days. Respiration postharvest increased in the immature-harvested fruits. Fresh weight loss exceeded 10% but without compromising appearance. The commercially immature-harvested fruits had 55% more total phenols, whereas the ripe-harvested fruits had higher soluble solids and ascorbic acid contents. Pulp color, soluble solids/titratable acidity ratio and total carotenoid contents were similar regardless of the degree of maturity at harvest. During the days after the harvest of the commercially immature “coquinho azedo”, changes take place which cause them to resemble the fruit harvested ripe. Based on the evaluated traits, the early harvest did not compromise the ripening of the fruits.
Genetic variability of yam (Dioscorea trifida) genotypes in the Ucayali region, Peru
Authors: Tuisima-Coral Lady Laura , Guillén Huachua Wilfredo Felipe
Published: October 2022

The aim of this research was to assess genetic variability of yam Dioscorea trifida genotypes using morphological descriptors for the germplasm collection conserved in the Agricultural Experiment Station in Ucayali, Peru. Thirty-eight morphological traits were evaluated for 30 D. trifida genotypes over ten years; from the data we estimated the Shannon-Weaver diversity index (H’) and the coefficient of variation and performed principal component analysis and cluster analysis. Qualitative traits with high phenotypic diversity index were: petiole anthocyanin (0.86), internal tuber color (0.86), petiole color (0.81) and stem color (0.80). The quantitative traits with the highest coefficient of variation were: tuber weight per plant (33.01) and tuber yield (32.99). Seventy-six percent of the morphological variability is explained by four principal components, the first component is constituted by the characters tuber width, tuber weight per plant, and tuber yield (29%). Five groups of genotypes were also identified with statistically significant differences, where group B stands out for its higher yield in fewer days to harvest. This research reveals wide morphological diversity in genotypes of D. trifida; these results can be used to strengthen the conservation, management, and genetic improvement initiatives of this important species in the Peruvian Amazon.
Combining ability and selection of wheat populations for a tropical environment
Authors: Caletti Mezzomo Henrique , Casagrande Cleiton Renato , Machado e Silva Caique , Lima Gabriel Wolter , Borém Aluízio , Nardino Maicon
Published: October 2022

The selection of segregating populations with the potential for derived lines is essential for breeding programs. The present work analyzes the potential of tropical F2 wheat (Triticum aestivum L.) populations originated from complete diallel cross combinations. For this purpose, eight tropical wheat cultivars were combined in a complete diallel design in 2019 after F1 seeds were multiplied in a greenhouse and the seeds of 56 F2 populations, plus the eight parents, were evaluated in the field in Viçosa, MG, Brazil in the winter harvest of 2020 using a simple lattice design (8×8). The trait scores of (1) severity of tan spot (Pyrenophora tritici-repentis), (2) severity of wheat head blast (WHB) (Magnaporthe oryzae pathotype Triticum), (3) days to heading, (4) spike height, (5) and total grain weight of the plot were evaluated. We performed a diallel analysis using mixed models to obtain the effects of general combining ability (GCA), specific combining ability (SCA), and estimation of population genotypic values. The additive effect predominated for the control of all traits, except for spike height. There were greater GCA effects for the set of parental maternal plants. Heritability, in the narrow sense, ranged from 0.20 (blast) to 0.66 (heading). There was an effect of maternal GCA for all variables, while for paternal GCA the effect was only for days passed for head and total grain weight. Populations derived from the cultivars TBIO Aton, TBIO Ponteiro, and TBIO Sossego had lower disease severity, while the combinations from BRS 254, BRS 264, and BRS 394 had earlier maturation time. The most promising combinations to derive lines for the set of traits were BRS 254 × CD 1303, BRS 394 × TBIO Aton, TBIO Aton × BRS 254, CD 1303 × BRS 254, and CD 1303 × BRS 264.
Aproximaciones al ensamblaje del agua desde el manejo de la alta montaña, caso de un sector del sistema Chingaza en Colombia
Authors: Méndez Olga Lucia
Published: October 2022

El manejo del territorio que surte de agua al sistema Chingaza, que abastece a Bogotá, es descifrado en este artículo, como un ensamblaje del gobierno de la alta montaña a partir del proyecto de adaptación al cambio climático inap y el proyecto del Corredor de Conservación de Páramos (cpp) implementados en un sector del sistema Chingaza: la cuenca alta del río Blanco. El ensamblaje devela las distintas funciones que se asignan al agua y los roles estipulados a la población campesina, lo cual va constituyendo determinadas gubernamentalidades en el territorio. Así, a pesar de que los proyectos recientemente implementados hicieron un importante esfuerzo por desmarcarse de estas prácticas, persisten conocimientos, narrativas y prácticas, propias, inclusive, de otros tiempos y lugares, lo cual permite que los patrones fragmentadores y jerárquicos del ensamblaje sean perpetuados.
Uso do teatro e ambiente virtual Google Classroom como instrumentos de mediação da aprendizagem no ensino de Química
Authors: Costa Francisco José da Costa , Magalhães Antonio Carlos
Published: October 2022

Este estudo apresenta uma pesquisa que utiliza o teatro e o ambiente virtual de aprendizagem Google Classroom para produzir um ensino de Química mais lúdico, dinâmico, contextualizado e consequentemente tornando mais efetiva a aprendizagem dos conteúdos deste componente curricular no ensino médio. A metodologia apresenta uma sequência de ações, tais como: aplicação de questionário de percepção dos estudantes sobre o ensino de Química, preparação e apresentação das peças teatrais pelos alunos, discussão sobre os conceitos abordados nas peças na sala de aula virtual Google Classroom, aplicação de questionário final sobre o impacto da metodologia na aprendizagem. Os resultados mostraram que o uso do teatro e de ambiente virtual pode promover um ensino de Química mais colaborativo, contextualizado e criativo, no qual os estudantes tornaram-se protagonistas no processo de aprendizagem. Também se evidenciou aceitação do uso do teatro como instrumento pedagógico de aprendizagem dos conteúdos de Química de uma forma mais crítica, reflexiva, tornando esses conteúdos mais contextualizados com o dia a dia dos estudantes.
Palavras-chave: Teatro; mediação da aprendizagem; ensino de Química.
Punitive damages under Chinese patent law
Authors:   The Institute of Legal Studies, Kyunghee University, JIN XIANGQI , PARK Soo-Gon
Published: October 2022

In today's society, when the perpetrator's malicious and intentional rights are violated, effective discipline is difficult with only compensatory damages. With the development of China's economy and high-tech technologies (artificial intelligence, 5G, etc.), the importance of protecting intellectual property rights is increasing day by day. Accordingly, China introduced punitive damages in which intellectual property rights are mixed with civil tort liability and a fine of a punitive nature. Punitive Damages are damages imposed for the purpose of punishing the infringer in a civil trial when the act of an intellectual property infringer intentionally or maliciously commits an illegal act such as implementation or use. It is a system that imposes a large amount of compensation.
China implemented punitive damages for patent infringement from June 2021 through the revision of the “Patent Law” in October 2020. This amendment significantly strengthened sanctions against patent infringement in order to prevent patent infringement and protect patent holders. The contents of the amendment stand out, including punitive damages up to five times in case of intentional infringement, an order to submit documents, and an increase of 500 yuan in legal damages. In this paper, we mainly look at the legal application of the punitive damages system in case of infringement of patent rights.
El Logos y la Creación. La referencia al Logos en el «principio» de Gén 1,1, según Filón de Alejandría
Authors: Moreno Martínez José Luis
Published: October 2022

1. El Logos como «lugar» del mundo inteligible: a) El Logos, Entendimiento divino planificador; b) El Logos, como seno materno. 2. El Logos como «principio»: a) Significado de la denominaci6n «principio» aplicada al Logos; b) Conexión6n de la denominación «principio» con Gén 1,1. 3. El Logos como «arquetipo»: a) La función del Logos como «arquetipo»; b) Conexión de la denominación «arquetipo » con Gén 1,1. 4. Conclusiones: Relación de Gén 1,1 con Prov 8,22-30.
La Imagen de Lutero en España: su evolución histórica
Authors: Goñi Gaztambide José
Published: October 2022

Introducción.-Las primeras reacciones españolas.-Los teólogos españoles y Lutero.-Los espirituales y Lutero.-Lutero en la historiografía moderna. Antítesis barrocas.-Lutero en la Edad Contemporánea.-Lutero en obras generales del siglo XIX.-Lutero en los Manuales de Historia eclesiástica.-Lutero en diccionarios y enciclopedias españoles.-Lutero en la historiografía profana.-Biografías de Lutero.-Trabajos varios.-Conclusiones.
L'indissolubilité du mariage et le monde féminin d'après la doctrine évangélique et quelques autres données bibliques parallèles
Authors: Feuillet André
Published: October 2022

SOMMAIRE: Introduction: Objet et méthode de notre recherche. I. L'ENSEIGNEMENT DU CHRIST SUR LE MARIAGE D'APRÉS L'ÉVANGILE DE SAINT MARC ET QUELQUES AUTRES DONNÉES PARALLÈLES OU COMPLÉMENTAIRES DU NOEVAU TESTAMENT. 1. La controverse sur le mariage de Mc 10, 1-12. 2. Comparaison avec quelques données de Luc (16,18), de Paul (1 Co 7, 10-16 et Rm 7, 1-6) et de Jean (7,53 - 8,11). II. LES TEXTES DU PREMIER ÉVANGILE SUR L'INDISSOLUBILITÉ DU LIEN CONJUGAL. REFLEXIONS SUR LA DOCTRINE ÉVANGÉLIQUE RELATIVE AU MARIAGE ET AU MONDE FÉMININ. 1. Le récit matthéen de la controverse sur le mariage (19, 3-12); les clausules d'exception de Mt 19, 9 et 5,32. 2. L'historicité et la grandeur de la doctrine évangélique sur le marriage. 3. Le message évangélique et le monde féminin. 4. Comparaison entre les deux récits de Mc 10, 1-12 et de Mt 19, 3-12; la forme la plus archaïque de l'enseignement évangélique sur le mariage. Conclusion Génerales: De l'institution du mariage chrétien dans les Évangiles á son examples suprème: l'union nuptiales du Christ et de son Èglise. Observations sur l'allégorie nuptiale dans l'Ancieu Testament.
Origen de la expresión «res et sacramentum»
Authors: López-González Pedro
Published: October 2022

SUMARIO: 1. San Agustín.-2. El misterio eucarístico en el siglo IX: Pascasio Radberto y Ratramno de Corbie.-3. Siglo XI: Berengario de Tours y Lanfraco de Bec.-4. Ivo de Chartres.-5. Aparición de la expresión res et sacramentun en la Teología sacramentaria: a) Escuela de Laon; b) Hugo de San Víctor; c) Summa Sententiarum.
El valor de la tradición en el judaísmo medieval
Authors: García-Jalón Santiago
Published: October 2022

I. LA HEREJÍA KARAÍTA: 1. Origen y evolución histórica; a) Los principios karaítas; b) La argumentación. II. LA REACIÓN RABANITA: 1. El Sefer ha-Qabbalah de Abraham ben Daud; 2) La «Qabbalah».
El erasmismo en España
Authors: Goñi Gaztambide José
Published: October 2022

Introducción. I. Nacimiento (1516-1524). II. Apogeo (1525-1530). III. Declive, persecución y vida subterránea (1530-1615). IV. Frutos. V. Bibliografía sobre el erasmismo en España.
Laicado y secularidad en la doctrina de fundador del Opus Dei
Authors: De Diego-Lora Carmelo
Published: October 2022

1. Introducción. 2. La concepción vocacional de laico en la Iglesia: a) la vocación específica del laico a la santidad y el apostolado en medio del mundo; b) modo de vivir su vocación laical el bautizado; c) la vocación laical bien vivida hace patente que el mundo pertenece a Dios; d) la misión santificadora de las realidades terrenas por el fiel laico. 3. La autonomía de la actividad secular: a) la misión del laico se cumple en coherencia con la vida cristiana; b) la dimensión civil de la vocación laical; c) la autonomía del obrar humano conlleva responsabilidad. 4. La operatividad eclesial del laico en el mundo: a) su servicio a la Iglesia en medio de las realidades temporales; b) la santificación del trabajo; c) la santificación de la vida familiar; d) el apostolado de los laicos. 5. Hacia una pastoral más orientada a iluminar la condición del laico en la Iglesia.
«Hominibus bonae voluntatis». Análisis filosófico-teológico y traducción
Authors: Guerra Gómez Manuel
Published: October 2022

SUMARIO.- I. El paralelismo antitético, quiasmático, del original griego, acentuado en la traducción latina. II. La traducción del original, inalterada desde la Vetus latina (s.II) hasta nuestros días. III. Bonae voluntatis, un genitivo de cualidad, referido a hominibus, no a Deo. IV. Bonae voluntatis, traducción del griego al latín en sintonía con la idiosincrasia de los latinos, romanos. V. Traducción castellana de Lc 2,14.
Autenticidad e historicidad del IV Evangelio
Authors: García-Moreno Antonio
Published: October 2022

1. Un Evangelio singular.- 2. Una importante clave de lectura.- 3. Sobre las anomalías en el texto.- 4. Aceptación del texto actual.- 5. Una antigua cuestión.- 6. A partir del modernismo.- 7. Acerca del origen del IV Evangelio.- 8. Ensayos sobre la composición del IV Evangelio.- 9. Otras hipótesis sobre la composición.- 10. Presencia de S. Juan en los orígenes.- 11. Sobre el modo de escribir en la antigüedad.- 12. Testimonios de la Tradición.- 13. Testimonio interno del libro.- 14. El Discípulo amado.- 15. Proclamación oral previa del Evangelio.- 16. Historicidad del relato joanneo.- 17. Historia y fe.- 18. El materialismo joanneo.- 19. El profundo sentido de la realidad.- 20. A modo de conclusión.
Notas introductorias al estudio de la Cristología
Authors: Mateo-Seco Lucas F.
Published: October 2022

SUMARIO: 1. Cristo, objeto de la cristología.- 2. La investigación histórica sobre Jesús de Nazaret.- 3. Creemos en un solo Señor Jesucristo.- 4. El Jesús de la historia y el Cristo de la fe.- 5. Cristología «desde abajo» y cristología «desde arriba».- 6. Cristología y jesuología.- 7. La Iglesia, lugar de la fe en Cristo.- 8. La fe cristológica de los primeros Concilios. a) La pretendida helenización del cristianismo. b) El sentido de las enseñanzas conciliares. c) Las «cristologías «calcedonianas» y «no calcedonianas».- 9. La cristología y el misterio de Dios. a) La pre-existencia del Logos. b) El Hijo es Yahvé que salva. c) El Hijo revela el misterio íntimo de Dios.- 10. Cristología y soteriología.- 11. El nuevo Adán.
Las propuestas de Karl Rahner para una teología trinitaria sistemática
Authors: Aranda Antonio
Published: October 2022

I. ALGUNOS PRESUPUESTOS DEL PENSAMIENTO Y DEL MÉTODO TEOLÓGICO GENERAL DE KARL RAHNER. 1. Sobre su fundamento intelectual y espiritual.- 2. Una teología con intención pastoral.- 3. El método antropológico trascendental.- 4. El 'existencial' sobrenatural. II. EXPOSICIÓN DE LAS LINEAS DE FONDO DE LA SISTEMATIZACIÓN TRINITARIA RAHNERIANA. 1. Planteamiento de la cuestión: críticas a la teología anterior.- 2. El Grundaxiom de la teología trinitaria.- 3. Esbozo de una nueva sistematización.- 4. Sobre el concepto rahneriano de Persona divina. III. REFLEXIONES CRÍTICAS SOBRE LA SISTEMATIZACIÓN TRINITARIA EXPUESTA. 1. Sobre el concepto de autocomunicación de Dios.- 2. Sobre la cuestión de la encarnación de Dios.- 3. Sobre el Grundaxiom: a) Las críticas de Congar y de Kasper; b) Reflexión crítica personal.
La economía de mercado, a la luz de la doctrina social de la Iglesia
Authors: Argandoña Antonio
Published: October 2022

La Encílica Rerum novarum dio en su momento un fuerte varapalo a la economía liberal dominante a finales del siglo pasado. Desde entonces, moralistas, filósofos y economistas andan divididos acerca de la moralidad del sistema económico llamado economía de mercado.

Sería presuntuoso por mi parte intentar dar aquí una respuesta definitiva a esa cuestión. Mi objetivo es mucho más modesto: como economista, me propongo identificar los rasgos característicos de la economía de mercado, para contrastarlos con lo que el Magisterio de la Iglesia ha dicho sobre ellos a lo largo del siglo transcurrido desde la publicación de la Rerum novarum. Espero con ello identificar, primero, las razones de fondo que apoyan el rechazo o la aceptación de la economía de mercado; analizar, después, cómo afectan esas razones a los elementos esenciales del sistema económico, para precisar los requisitos que la Doctrina Social cristiana exige a la economía de mercado, a fin de que resulte un sistema moralmente aceptable, e identificar las causas últimas de la reticencia con que la Iglesia ha mirado tradicionalmente a nuestro sistema económico. Deseo con ello responder a la petición del Cardenal Lustiger de que los economistas salgamos de nuestras sacristías para escuchar el lenguaje de la Iglesia.
El hecho religioso y su valoración
Authors: Morales José
Published: October 2022

1. Crisis y retorno de la religión en nuestros días.- 2. Hacia una concepción teológica y sustantiva de la religión.- 3. Religión y Revelación.- 4. La acción transformadora de la Religión Revelada.
En torno al derásh en el IV Evangelio
Authors: García-Moreno A.
Published: October 2022

This work begins with a reasonable evaluation of the Midrashic methods, presenting them as basic tools for understanding the New Testament writings, though advening that such methods constitute a means and not an end. The work passes on to expound the significance of derash and its diverse forms, and arrives at the condusion that the idea of fulfillment is fundamental in the New Testament derash. This is what makes the New Testament derash different from the Jewish derash; whereas the latter offers a commentary on the books of the Old Testament, the New Testament writings sustain that whatever was said in the Law and in the Prophets is realized and fulfilled in Jesus Christ. It is also possible to speak of a derash that is confirmatory and besides, selective, insofar as the hagiographers of the New Testament select diverse passages from the Old, and confirm that what is there announced is realized and fulfilled in Jesus Christ. As an example, the anide surveys the first section of the Book of Signs in Sto John.
Iglesia Católica y confesiones cristianas frente a las sectas en América Latina
Authors: Aranda Antonio
Published: October 2022

I. SITUACIÓN DE LA CUESTIÓN.- Bibliografía general reciente. II. SECTAS y NUEVOS MOVIMIENTOS RELIGIOSOS EN AMÉRICA LATINA: CARACTERÍSTICAS MORFOLÓGICAS, TIPOLOGÍA, EXTENSIÓN.- Bibliografía general reciente. III. ACTITUD PASTORAL DE LA IGLESIA CATÓLICA ANTE EL DESAFÍO DE LAS SECTAS EN LATINOAMÉRICA.- Bibliografía reciente. a) Iglesia Católica. b) Consejo Ecuménico de las Iglesias. IV. ELEMENTOS DE REFLEXIÓN TEOLÓGICA.-
Trabajo, Caridad, Justicia
Authors: Illanes José Luis
Published: October 2022

1. El trabajo, elemento nuclear de la doctrina espiritual del beato ]osemaría Escrivá. 2. Trabajo profesional y vivencia cristiana. 3. En la cumbre de todas las actividades humanas. 4. En torno a los desarrollos de la teología del trabajo. 5. Responsabilidad social, caridad, justicia.
La intención y el género literario de «Camino» del Beato Josemaría Escrivá de Balaguer
Authors: Gondrand François
Published: October 2022

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La fe y la lógica del testimonio
Authors: Conesa Francisco
Published: October 2022

1. La fe como aceptación del mensaje de salvación. 2. Epistemología del saber por testimonio. 3. La revelación como testimonio. 4. Creer en Dios es razonable. 5. La fe como modo peculiar de saber.
A research on demonstrating contribution of variables in neural network analysis on korean export gravity model
Authors:   Korea Association for International Commerce and Information, Roh Jaewhak
Published: October 2022

The artificial neural network analysis has the advantage of being able to identify non-linear relationships between variables that is hard to be found in parametric research methods. On the other hands, this non-parametric black box methods have limitations to show the contribution of variables due to complexity of relations.
In this study, a dummy artificial neural network analysis is attempted on the gravity model of panel data for Korea's exports, and the contribution of the variables are presented by Partial Dependence Plots methods.
This results also show that the existence of a non-linear relationship that was hard to be captured by the previous parametric researches. Especially, the non-linearity contribution were found in GDP, per capita GDP and remoteness variables.
Association between the compulsory notification of violence and the municipal human development index
Authors: Bandeira Ângela Grubel , Martínez-Mesa Jeovany
Published: October 2022

Objetivando conhecer se o índice de desenvolvimento humano dos municípios brasileiros (IDHM) está associado com a notificação compulsória de violência nos serviços de saúde realizou-se o presente estudo. Trata-se de um estudo observacional, com delineamento ecológico, utilizando dados dos 5565 municípios brasileiros, tanto da notificação de violência, extraídos do DATASUS como do IDHM, extraídos do Programa das Nações Unidas para o Desenvolvimento (PNUD). Os resultados demonstram que existe correlação positiva entre a notificação compulsória de violência em geral e o IDHM. A exceção foi a macrorregião Sudeste onde o coeficiente foi negativo. Na notificação compulsória de violência contra as mulheres existe correlação positiva com IDHM para a maioria das violências, exceto a macrorregião Sudeste, que se mantém negativa. Os resultados sobre a notificação compulsória contra homens, da mesma forma, indicam correlação positiva com o IDHM para a maioria das violências, com exceção da macrorregião Sudeste, que também foi negativa. O quesito tipo de violência financeira apresentou coeficiente negativo tanto no Brasil, como em todas as macrorregiões, seja para violência contra homens, seja contra mulheres. A violência psicológica apresentou-se negativa quando analisada na notificação compulsória de violência contra homens. O estudo concluiu que a notificação compulsória de violência está presente em municípios que possuem melhores índices de desenvolvimento humano. A violência financeira ainda se mostra desconhecida e pouco abordada nos serviços de atenção primária à saúde, como, também, a violência psicológica sofrida por homens não é reconhecida, demonstrando uma cultura de tolerância a esse tipo de violência.
Sponsors
Authors: Horswill Ian
Published: October 2022

List of sponsors of Tenth AAAI Conference on Artificial Intelligence and Interactive Digital Entertainment.
Invited Talks
Authors: Carr Peter , Eiserloh Squirrel , Ingebretson Peter
Published: October 2022

Biographical statements about the AIIDE-14 speakers Peter Carr, Squirrel (Brian) Eiserloh, and Peter Ingebretson.
Walling in Strategy Games via Constraint Optimization
Authors: Richoux Florian , Uriarte Alberto , Ontañón Santiago
Published: October 2022

This paper presents a constraint optimization approach to walling in real-time strategy (RTS) games. Walling is a specific type of spatial reasoning, typically employed by human expert players and not currently fully exploited in RTS game AI, consisting on finding configurations of buildings to completely or partially block paths. Our approach is based on local search, and is specifically designed for the real-time nature of RTS games. We present experiments in the context of the RTS game StarCraft showing promising results.
An AI System for Large Open Virtual World
Authors: Plch Tomas , Marko Matej , Ondracek Petr , Cerny Martin , Gemrot Jakub , Brom Cyril
Published: October 2022

In recent years, computer games have reached unprecedented level of graphical fidelity to the real world. As the non-player characters (NPCs) in the game world look more and more realistic, players expect them to manifest believable behavior as well. This is accented especially in games that feature large open worlds, which players may explore freely and it is thus not possible to explicitly account for all possible player interactions. In this paper we focus mainly on ambient AI - the logic behind day to day behaviors of NPCs as they sleep, work and entertain themselves in the virtual world. In this context, it is of great importance to build a system that handles many NPCs (up to several hundreds) quickly. In this paper we report on an implementation of a particular AI system that was approved for deployment in an upcoming high-budget game. The system features a hierarchy of control similar to the subsumption architecture and a visual agent-based language inspired by behavior trees. We describe the challenges involved in building such a system and specific design decisions we have made that let us achieve a level of behavioral fidelity unmatched by existing games. Finally we evaluate the performance of the system in a realistic setting.
Towards Personalised Gaming via Facial Expression Recognition
Authors: Mavromoustakos Blom Paris , Bakkes Sander , Tan Chek , Whiteson Shimon , Roijers Diederik , Valenti Roberto , Gevers Theo
Published: October 2022

In this paper we propose an approach for personalising the space in which a game is played (i.e., levels) dependent on classifications of the user's facial expression  — to the end of tailoring the affective game experience to the individual user. Our approach is aimed at online game personalisation, i.e., the game experience is personalised during actual play of the game. A key insight of this paper is that game personalisation techniques can leverage novel computer vision-based techniques to unobtrusively infer player experiences automatically based on facial expression analysis. Specifically, to the end of tailoring the affective game experience to the individual user, in this paper we (1) leverage the proven InSight facial expression recognition SDK as a model of the user's affective state InSight, and (2) employ this model for guiding the online game personalisation process. User studies that validate the game personalisation approach in the actual video game Infinite Mario Bros. reveal that it provides an effective basis for converging to an appropriate affective state for the individual human player.
Using Cyclic Scheduling to Generate Believable Behavior in Games
Authors: Zhao Richard , Szafron Duane
Published: October 2022

Video game virtual characters should interact with the player, each other, and the environment. However, the cost of scripting complex behaviors becomes a bottleneck in content creation. Our goal is to help game designers to more easily populate their open world with background characters that exhibit more believable behaviors. We use a cyclic scheduling model that generates dynamic schedules for the daily lives of virtual characters. The scheduler employs a tiered behavior architecture where behavior components are modular and reusable. This research validates the designer usability of an implementation of this model. We present the results of a user study that evaluates the scheduling system versus manual scripting based on three metrics of behavior creation: behavior completeness, behavior correctness and behavior implementation time. The results indicate that the behavior architecture produces more reliable behaviors and improves designer efficiency which will reduce the cost of generating more believable character behaviors.
Foreseeing Meaningful Choices
Authors: Cardona-Rivera Rogelio , Robertson Justus , Ware Stephen , Harrison Brent , Roberts David , Young R.
Published: October 2022

A choice positively contributes to a player's sense of agency when it leads to meaningfully different content. We shed light on what a player may consider meaningfully different by developing a formalism for interactive stories in terms of the change in situational content across choices. We hypothesized that a player will feel a higher sense of agency when making a choice if they foresee the available actions lead to meaningfully different states. We experimentally tested our formalism's ability to characterize choices that elicit a higher sense of agency and present evidence that supports our claim. Study participants (n=88) played a choose-your-own-adventure game and reported a higher sense of agency when faced with choices that differed in situational content over choices that didn't, despite these choices differing in non-situational ways. We contend our findings are a step toward principled approaches to the design of interactive stories that target specific cognitive and affective states.
Deep Learning-Based Goal Recognition in Open-Ended Digital Games
Authors: Min Wookhee , Ha Eun , Rowe Jonathan , Mott Bradford , Lester James
Published: October 2022

While many open-ended digital games feature non-linear storylines and multiple solution paths, it is challenging for game developers to create effective game experiences in these settings due to the freedom given to the player. To address these challenges, goal recognition, a computational player-modeling task, has been investigated to enable digital games to dynamically predict players’ goals. This paper presents a goal recognition framework based on stacked denoising autoencoders, a variant of deep learning. The learned goal recognition models, which are trained from a corpus of player interactions, not only offer improved performance, but also offer the substantial advantage of eliminating the need for labor-intensive feature engineering. An evaluation demonstrates that the deep learning-based goal recognition framework significantly outperforms the previous state-of-the-art goal recognition approach based on Markov logic networks.