bluuebunny/crossref_metadata_2025 huggingface dataset:
A single case study of role of Shodhan and Shaman Karma in the management of Vicharchika (Eczema)
Authors: Neha A Bhangire  , Shubham M Bhagat  , Ashish C. Zanwar
Published: February 2025

In Ayurveda skin diseases are included in Kushtaroga which is divided into two types that is Mahakushta and Kshudrakushta which are again sub- classified into seven types of Mahakushta and eleven types of Kshudrakushta. Vicharchika is a form of Kshudrakushta with Lakshanas like Kandu, Pidaka, Shyava, Bahustrava can be correlated with Eczema also called as dermatitis which is clinically manifests by pruritus, erythema, oedema, papules, vesicles and oozing in acute stage where as itching, scaling, dryness and lichenification occur in chronic stage. According to Sushruta Acharya, Pitta Dosha is the predominant dosha in Vicharchika. Virechan and Raktamokshan is the most effective body purification procedure useful to regulate the function of Pittaj and Raktaj Vyadhi. A case report of 58-year-old male, who presented with complaints of swelling of right foot followed by itching, pain eventually leading to watery discharge has been treated with Ayurveda modalities Shodhan and Shaman Aushadhi for 1 month.
An In-vitro, In-vivo and Clinical Trials of Somaraji Taila in the management of Dadru Kushta
Authors: Prashanth Gadgade  , Susheel Shetty  , Babu Paul
Published: February 2025

Dermatophytosis has become a significant health problem affecting children, adolescents, and adults worldwide. In India 5 out of 1000 people suffer from Tinea infections. The present study evaluated the antifungal activity of Somaraji Taila in Tinea (Dermatophytosis) in Invitro & Invivo model. Cultures were brought from MTCC a government body and inoculated in SDA media under aseptic condition. Later it was subjected to microscopic and macroscopic examination to identify the organism. A sensitivity test was done using SDA media by well diffusion method, with 4 different concentrations of Hydro-Methanolic extraction of Somaraji Taila ingredients. After the incubation period, the zone of inhibition was checked and was measured in mm. As the next phase of the study, animal study was also conducted to check antifungal properties & anti-dermal toxicity on albino rat skin and conducted clinical study on 30 Diagnosed subject Dadru Kushta who were randomly allocated with 15 each in two groups. Somaraji Taila was taken for one group which was compared against widely used clinical formulation Chakramarda Taila taken as standard for local application in another group. The application was done for 14 days, and the data was collected from the subjects at baseline, 8th day (during treatment), 15th day (after treatment) and 21st day (follow-up). The assessment was based on the KASI method of grading. The results of the study showed that there was there was highly statistically significant difference between the effect of Somaraji Taila and Chakramarda Taila in Dadru Kushta.
Role of Nitya Virechan and Shaman Aushadhi in Dadru Kushtha w.r.t. Tinia Corporis - A Case Study
Authors: Ashish C. Zanwar  , Sanskruti P. Muley
Published: February 2025

Ayurveda have been classified all the skin diseases under the broad heading of ‘Kushta’ which were sub classified into Mahakushta and Kshudrakushta. Hetu (Causative factors) of Dadru Kushta involves Vishamashana (Incompatible food), Vegavidharana (suppression of natural urges), Diwaswapa (daytime sleeping), intake of Atilavana, Atitikshnaahar (excessive salty or spicy food), intake of contaminated food, drinking cold water just after physical work or Atapsevana (exposure to sunlight). Lakshanas of Dadru include Kandu (Itching), Utsanna (elevated circular lesions), Mandala (Circular Patches), Raaga (Erythema), and Pidakas (Papule). The Samprapti of Dadru mainly involves vitiation of Pitta-kapha Doshas and Dushti of rasa and Raktavaha Strotas. A 56 year old male patient, came to OPD with the complaints of reddish circular patch on chest and back with sever itching and burning sensation since last 3 months. After examination patient was diagnosed as case of Dadru Kushth and was treated with Ayurvedic management protocol i.e., Abyantar Snehan with Nitya Virechan, Shaman Aushdhi and Bahirparimarjan Chikitsa for 1 month and was taken follow up after 14days. Dietary restriction was advised to avoid spicy and junk food along with personal hygiene to be maintained. After complete treatment of 1 month patient was assessed with parameter like raga (redness), Kandu (itching), Daha (burning sensation), and Utsana Mandal on a grade from 0 to 3 and there was significant improvement was noted. From this case study it can be concluded that use of Nitya Virechan with Snehapan with Panchatikta Ghruta and Shaman Aushdhi along with Bahya Chikitsa can treat Dadru Kushta.
A comparative clinical study of Swarnamakshika Bhasma and Dhatri Lauha in the management of Pandu w.s.r. to Iron Deficiency Anaemia
Authors: Yogendra Kumar  , Anita Pal
Published: February 2025

Anaemia, a silent condition without symptoms, can lead to chronic health issues such as impaired fatal development, delayed cognitive development, increased risk of infection in young children, and reduced physical capacity. Women of childbearing age need to absorb 2-3 times the amount of iron required by men or older women. In Ayurveda, Pandu is a specific disease with its own pathogenesis and treatment. In India, Anemia affects 50% of the population, with 20 - 40% of maternal deaths due to anemia. Allopathic treatment for mild to moderate anemia involves supplementation of ferrous sulfate, fumarate, or gluconate. Ayurveda can provide better management in this area. The objective of the study is to know the efficacy of Swarnamakshika Bhasma and Dhatriloha in Pandu. 40 patients of Pandu (iron deficiency anemia) were taken who fulfilled the inclusion criteria and divided into two groups randomly. Group A - 20 patients of Pandu (IDA) were given Swarnamakshika Bhasma. Group B - 20 patients of Pandu (IDA) were given Dhatri Loha for 45 days. Both the groups are having similar effect on reducing the symptoms statistically. Among the subjective and objective parameters, the B group showed better results than Group A.
The clinical study to evaluate the Rasayana effect of Bharangi Guda in Post-Covid Subjects - Research Article
Authors: Roopa N  , SN Belavadi
Published: February 2025

In COVID-19, long term intake of Antivirals, Antibiotics, Antimicrobials, Corticosteroids and ventilator exposure leads to ill effect in individual. Such as Fatigue, Weight loss, Weakness, Intermittent raise in Temperature, Headaches, Myalgias etc. are signs and symptoms noted in after effect of COVID-19. It is necessary to combat Post-covid signs and symptoms in patients and restore the normalcy of body functions or to build their immune system. Rasayana an Ayurvedic rejuvenation therapy which helps in maintenance and promotion of health. It means nutrition at all levels from macro to micro cellular levels. Replenishes from the vital fluids of body; boost the Ojas (immune system), thus keeping away from diseases. In the study; Naimittika Rasayana (consequent to diseases), Bharangi Guda which is indicated in Pranavaha Sroto Vikara like Swasa (asthma), Kasa (cough), Jwara (fever) etc. Ingredients like Bharangi, Dashamoola, Harithaki, Guda, Trikatu, Trijatha, Yava. Actions like Antispasmodic, Anti-asthmatic, Carminative, Antihistaminic principle, Tonic and refrigerant. Active principles like Saponin, D-mannitol, Tanin etc. Study design is Simple Randomized Clinical Study. Total 30 post-COVID patients shows highly significant in subjective parameters and significant and not-significant in objective parameters.
A randomized controlled clinical study to evaluate the efficacy of Karanja Patra Arka in the management of Dusta Vrana vis-à-vis Chronic Non-Healing Ulcer
Authors: Ravindra M Joshi  , Gururaja D
Published: February 2025

Background: Dusta Vrana is a prevalent surgical issue that delays healing due to infection, slough, poor hygiene, and foreign bodies. A holistic approach is essential for chronic leg ulcer care, addressing underlying causes, accurate diagnosis, and peculiar treatment. Karanja patra is indicated for wound management in Arka Prakasha. Therefore, this study seeks to assess this aspect. Objectives: To evaluate the efficacy of Karanja Patra Arka in the management of Dushta Vrana and to compare the efficacy of Karanjapatra Arka and Gomutra Arka. Methodology: A single-blind study with a total number of 40 patients with selection criteria of Dushta Vrana were included in this study. In Group A Karanja Patra Arka wound dressing. In Control: Gomutra Arka dressing. Daily wound care for 30 days or granulation tissue formation. Weekly follow-ups and statistical analyses were done. Result: A significant improvement was noted in both subjective (Pain, Itching, and smell) and objective (Bates Jenson criteria) outcomes. Conclusion: Both Arkas shows improvement in subjective symptoms (smell, itching, pain), but differ in their objective outcomes. Karanjapatra Arka excelled in wound healing (Vrana Ropana), while Gomutra Arka showed stronger wound cleansing (Vrana Shodhana).
The Transformative Power of NIH Funding: Advancing Careers, Science, and Public Health
Authors:   Neuromodulation Center and Center for Clinical Research Learning, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard Medical School, Boston, USA, Almarie Bassel , Fregni Felipe ,   Neuromodulation Center and Center for Clinical Research Learning, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard Medical School, Boston, USA
Published: February 2025

NA
Impacto económico de las importaciones chinas en Colombia y su influencia en el desarrollo local
Authors:   Bustamante Matoma, Bustamante Matoma Harold
Published: February 2025

Introducción: China se ha convertido en unos de los principales socios comerciales de Colombia, convirtiéndose en uno de los principales proveedores de las importaciones para el país, es por ello por lo que los principales bienes y servicios importados han presentado un impacto significativo en la economía y desarrollo local. Objetivo: el análisis de las importaciones de China en el contexto colombiano y su incidencia en el desarrollo económico local. Metodologia: correspondió de carácter cuantitativo, de alcance explicativo mediante una exhaustiva revisión de literatura y diseño de un instrumento tipo encuesta cerrada, valorada en la escala Likert. Los datos fueron procesados por el Software Statistical Package for the Social Sciences, versión 29.0. En la que participaron (154) empresarios locales seleccionados por medio de un muestreo no probabilístico por conveniencia. Resultados: revelaron escenarios de mejora en términos de competitividad con los productos locales articulando las regulaciones y políticas comerciales frente a la competencia extranjera fortaleciendo la cooperación tanto del sector público- privado para el desarrollo del mercado local. Conclusión: las importaciones de china han generado beneficios y desafíos para los empresarios colombianos. Finalmente, se concluye con la implementación de estrategias que promuevan la innovación y diversificación de los productos locales para competir de manera más efectiva en el mercado global.
“RUMAHKU LABORATORIUM KIMIAKU”, BUKU EKSPERIMEN KIMIA DI KEHIDUPAN SEHARI-HARI SEBAGAI PENERAPAN KONSEP MATERI KIMIA DI SMA
Authors: Kurniawan Yohanes Dedi , Budimarwanti Cornelia
Published: February 2025

Penelitian ini adalah penelitian pengembangan dalam bidang pendidikan kimia. Tujuan dari penelitian ini adalah mengembangkan buku pedoman guru yang berisikan eksperimen kimia di kehidupan sehari-hari dan mengetahui kelayakan media pembelajaran berdasarkan penilaian 5 guru SMA. Dalam pengembangan buku eksperimen kimia peneliti menggunakan metode ADDIE yang terdiri dari 4 tahap, yaitu analisis, perencanaan, pengembangan dan implementasi. Buku eksperimen kimia yang telah dibuat kemudian divalidasi oleh dosen pembimbing, ahli media, ahli materi dan pembelajaran kimia. Kemudian produk dinilai oleh 5 guru kimia SMA sebagai reviewerKualitas buku eksperimen kimia dapat diketahui melalui penilaian lima guru kimia SMA yang ditinjau dari aspek isi, aspek kebahasaan, aspek penyajian, efek media terhadap strategi pembelajaran dan tampilan. Buku eksperimen kimia yang dikembangkan mendapat skor rata-rata 4,14 dari skor maksimal ideal 5 dengan kategori baik (B).
Colorectal Cancer Racial Equity Post Volume, Content, and Exposure: Observational Study Using Twitter Data
Authors: Tong Chau , Margolin Drew , Niederdeppe Jeff , Chunara Rumi , Liu Jiawei , Jih-Vieira Lea , King Andy J
Published: February 2025

Background

Racial inequity in health outcomes, particularly in colorectal cancer (CRC), remains one of the most pressing issues in cancer communication and public health. Social media platforms like Twitter (now X) provide opportunities to disseminate health equity information widely, yet little is known about the availability, content, and reach of racial health equity information related to CRC on these platforms. Addressing this gap is essential to leveraging social media for equitable health communication.

Objective

This study aims to analyze the volume, content, and exposure of CRC racial health equity tweets from identified CRC equity disseminator accounts on Twitter. These accounts were defined as those actively sharing information related to racial equity in CRC outcomes. By examining the behavior and impact of these disseminators, this study provides insights into how health equity content is shared and received on social media.

Methods

We identified accounts that posted CRC-related content on Twitter between 2019 and 2021. Accounts were classified as CRC equity disseminators (n=798) if they followed at least 2 CRC racial equity organization accounts. We analyzed the volume and content of racial equity–related CRC tweets (n=1134) from these accounts and categorized them by account type (experts vs nonexperts). Additionally, we evaluated exposure by analyzing follower reach (n=6,266,269) and the role of broker accounts—accounts serving as unique sources of CRC racial equity information to their followers.

Results

Among 19,559 tweets posted by 798 CRC equity disseminators, only 5.8% (n=1134) mentioned racially and ethnically minoritized groups. Most of these tweets (641/1134, 57%) addressed disparities in outcomes, while fewer emphasized actionable content, such as symptoms (11/1134, 1%) or screening procedures (159/1134, 14%). Expert accounts (n=479; 716 tweets) were more likely to post CRC equity tweets compared with nonexpert accounts (n=319; 418 tweets). Broker accounts (n=500), or those with a substantial portion of followers relying on them for equity-related information, demonstrated the highest capacity for exposing followers to CRC equity content, thereby extending the reach of these critical messages to underserved communities.

Conclusions

This study emphasizes the critical roles played by expert and broker accounts in disseminating CRC racial equity information on social media. Despite the limited volume of equity-focused content, broker accounts were crucial in reaching otherwise unexposed audiences. Public health practitioners should focus on encouraging equity disseminators to share more actionable information, such as symptoms and screening benefits, and implement measures to amplify the reach of such content on social media. Strengthening these efforts could help bridge disparities in cancer outcomes among racially minoritized groups.
Colorectal Cancer Racial Equity Post Volume, Content, and Exposure: Observational Study Using Twitter Data (Preprint)
Authors: Tong Chau , Margolin Drew , Niederdeppe Jeff , Chunara Rumi , Liu Jiawei , Jih-Vieira Lea , King Andy J
Published: February 2025

BACKGROUND

Racial inequity in health outcomes, particularly in colorectal cancer (CRC), remains one of the most pressing issues in cancer communication and public health. Social media platforms like Twitter (now X) provide opportunities to disseminate health equity information widely, yet little is known about the availability, content, and reach of racial health equity information related to CRC on these platforms. Addressing this gap is essential to leveraging social media for equitable health communication.

OBJECTIVE

This study aims to analyze the volume, content, and exposure of CRC racial health equity tweets from identified CRC equity disseminator accounts on Twitter. These accounts were defined as those actively sharing information related to racial equity in CRC outcomes. By examining the behavior and impact of these disseminators, this study provides insights into how health equity content is shared and received on social media.

METHODS

We identified accounts that posted CRC-related content on Twitter between 2019 and 2021. Accounts were classified as CRC equity disseminators (n=798) if they followed at least 2 CRC racial equity organization accounts. We analyzed the volume and content of racial equity–related CRC tweets (n=1134) from these accounts and categorized them by account type (experts vs nonexperts). Additionally, we evaluated exposure by analyzing follower reach (n=6,266,269) and the role of broker accounts—accounts serving as unique sources of CRC racial equity information to their followers.

RESULTS

Among 19,559 tweets posted by 798 CRC equity disseminators, only 5.8% (n=1134) mentioned racially and ethnically minoritized groups. Most of these tweets (641/1134, 57%) addressed disparities in outcomes, while fewer emphasized actionable content, such as symptoms (11/1134, 1%) or screening procedures (159/1134, 14%). Expert accounts (n=479; 716 tweets) were more likely to post CRC equity tweets compared with nonexpert accounts (n=319; 418 tweets). Broker accounts (n=500), or those with a substantial portion of followers relying on them for equity-related information, demonstrated the highest capacity for exposing followers to CRC equity content, thereby extending the reach of these critical messages to underserved communities.

CONCLUSIONS

This study emphasizes the critical roles played by expert and broker accounts in disseminating CRC racial equity information on social media. Despite the limited volume of equity-focused content, broker accounts were crucial in reaching otherwise unexposed audiences. Public health practitioners should focus on encouraging equity disseminators to share more actionable information, such as symptoms and screening benefits, and implement measures to amplify the reach of such content on social media. Strengthening these efforts could help bridge disparities in cancer outcomes among racially minoritized groups.
Discreet initial trust construction in Internet healthcare services: the dual role of organizational and role signals (Preprint)
Authors: Zhang Zehong , Lai Lingqi , xu wanyu , Zhao Zhangzhang , Wang Pei
Published: February 2025

BACKGROUND

The deepening development of Internet healthcare from empowering “non-core healthcare” to empowering “core healthcare” has brought about a “double-addition” paradox, which increases both value and risk, thus making the role of patient trust, especially initial trust, in Internet healthcare services more prominent. This makes the role of patient trust, especially initial trust, in Internet healthcare services more prominent.However, it is unclear what “observable” trust signals contribute to the generation of initial trust in Internet healthcare services.

OBJECTIVE

This study aims to explore the “observable” trust signals that drive the generation of prudent initial trust in Internet healthcare services and their roles by constructing and testing a trust signaling framework of prudent initial trust based on initial trust theory and signaling theory.

METHODS

A national online cross-sectional questionnaire was administered to those with experience in online medical care (N=2027), and the results were analyzed using descriptive statistics with optimal scale regression statistics.

RESULTS

Organizational competence (β= 0.43, p < .001) and role competence (β= 0.41, p < .001) had the greatest impact on cautious initial trust in Internet healthcare services; organizational goodwill (β= 0.30, p < .001) and role goodwill (β= 0.31, p < .001) had a greater impact on cautious initial trust in Internet healthcare services.Competence signaling had a greater impact on initial trust than goodwill signaling. Trust propensity played a moderating role in organizational signaling (β= -0.06, p < .01) versus role signaling (β= -0.08, p < .001) on cautious initial trust in Internet healthcare services.

CONCLUSIONS

Initial trust in Internet healthcare services is mainly driven by “observable” trust signals, i.e., both organizational and role signals.Organizational signals consisting of organizational competence and organizational goodwill played a transmission effect in the generation of cautious initial trust in Internet healthcare services, and role signals consisting of role competence and role goodwill played a competence effect.In the future, the design of competitive mechanisms, user thinking, value incentives and authenticity audits should be used to promote platforms and online doctors to consistently send trust signals of their competence and goodwill.These results clarify the directions that Internet healthcare services should focus on from the perspective of prudent trust, while proposing a trust signaling impact theory for initial trust.
Evaluating AI-Driven Mobile Applications and Open-Source Software for Assessing Facial Growth and Development: A Retrospective Observational Study (Preprint)
Authors: Bustamante Araya Maria Ignacia , Muradas Odriozola Gonzalo , Coudyzer Walter , Jacobs Reinhilde
Published: February 2025

BACKGROUND

Facial growth and development are dynamic processes influenced by intrinsic and extrinsic factors. Predicting these changes is essential in forensic science and clinical dentistry. While AI-driven age progression tools like Remini AI (a mobile application) and SAM (open-source software) may offer innovative solutions, their clinical applicability remains underexplored.

OBJECTIVE

To evaluate the accuracy and clinical feasibility of AI-driven age progression tools: using a mobile application (Remini AI) and an open-source software (SAM).

METHODS

This retrospective observational study used the FG-NET aging database and additional personal images. Remini AI and SAM processed 18 images each, generating 180 age-progressed images in total for predefined age groups (5, 11, 15, 18, and 26 years). Subjective assessments involved dental experts performing reordering, categorization, and accuracy tasks, while objective assessments used an age estimation model (MiVolo) to estimate the age of the AI-generated images. Statistical analyses included t-tests and chi-square tests with a significance level of 5%.

RESULTS

Remini AI achieved higher results for the categorization task (55%, P < .001), whereas SAM demonstrated superior accuracy in generating realistic age progressions between 11 and 18 years old, with a lower mean absolute error (2.7 years vs. 3.7 years, P < .001). Neither tool performed effectively for younger (age 5) or older (age 26) age groups. SAM outperformed Remini AI in processing speed, generating images in an average of 9 seconds versus 5 minutes per image (P < .001).

CONCLUSIONS

Remini AI excels in categorization tasks, while SAM demonstrates greater accuracy and efficiency for realistic age progressions, particularly in mid-childhood and young adulthood. Both tools require refinement for younger and older populations. These findings emphasize the potential of AI-driven tools in forensic investigations and clinical dentistry, including orthodontic planning and reconstructive procedures.

CLINICALTRIAL

This study is retrospective and observational, and no trial registration is applicable.
Prenatal, childhood and adolescent exposure to Volatile Organic Compounds and Health Outcomes: A Scoping Review protocol to Map the Level of Evidence (Preprint)
Authors: Bah Homègnon Antonin Ferréol , Leydet Emily , Connell Mackenzie L. , Cassidy-Bushrow Andrea E. , Straughen Jennifer K.
Published: February 2025

BACKGROUND

VOCs are a diverse group of organic chemicals with widespread presence in daily life. VOCs may have detrimental health effects on humans, particularly during critical periods such as pregnancy, childhood, and adolescence.

OBJECTIVE

This ongoing scoping review aims to map the current evidence concerning exposure to volatile organic compounds (VOCs) and associations with pregnancy outcomes and health during pregnancy, childhood, and adolescence.

METHODS

This review will consider studies investigating potential health effects related to exposures to either total VOCs or any of the following six specific VOCs: Benzene, Toluene, Ethylbenzene, Xylene, Trichloroethylene (TCE), and Tetrachloroethylene/perchloroethylene (PCE) during critical windows from pregnancy through adolescence. Original articles published in English from January 1, 2000, through the end of the scoping review period, will be included. This review will follow the JBI methodology for scoping reviews, and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR). The literature search will use Ovid Medline, Embase, and Web of Science databases. Two reviewers will screen and extract the information separately; in case of discrepancy, both will discuss to reach a consensus, and a third reviewer may intervene if needed. Reviewers will provide commentaries of their findings from the included studies and suggest areas of interest for future studies.

RESULTS

The literature search yielded 7332 citations with screening underway. After data extraction and a complementary literature search, the results will be submitted for publication in a peer-reviewed journal.

CONCLUSIONS

The results are expected to summarize the current state of knowledge on the association of VOCs with health at critical life stages (pregnancy, childhood, and adolescence). We anticipate identifying gaps in the literature as well that could guide future research priorities.

CLINICALTRIAL

Protocol registration (Open Science Framework): https://osf.io/ep73g
From Classroom to Operating Room: Addressing Shortcomings in Gender Affirmation Surgical Education (Preprint)
Authors: Robinson Samuel G , Hamidian Jahromi Alireza
Published: February 2025

UNSTRUCTURED

The prevalence of American youth identifying as transgender has doubled in the past five years, emphasizing the crucial role of gender affirmation surgery (GAS) in treating gender dysphoria. However, the current healthcare infrastructure faces challenges in meeting the escalating demand for GAS interventions. Transgender and gender diverse (TGGD) patients encounter barriers, including travel and extended waitlists for specialized surgeons. This article highlights the insufficient exposure to GAS in medical education, spanning from medical students to attending surgeons, and examines the uneven distribution of GAS providers across specialties. The absence of formal training and board certification compounds the issue, urging a comprehensive reevaluation of medical education to ensure quality care for the expanding TGGD population.
“Will It Be Used for Me or Against Me?”: A Qualitative Study on the Use of Mobile Health Interventions Among Adolescents and Parents Living in Palestine. (Preprint)
Authors: Hamideh Dina , Al Zabadi Hamzeh , Mahmoud Lamees , Bridi Lana
Published: February 2025

BACKGROUND

The political determinants of health in Palestine are pronounced, impacting care for chronic disease. Mobile health (mHealth) is increasingly used for self-management of chronic conditions as cardiovascular disease or diabetes among adolescents and adults in other populations, but perceived acceptability among Palestinians remains unknown.

OBJECTIVE

To qualitatively assess the acceptability of potential mHealth interventions addressing pertinent health concerns among Palestinian adult and adolescent refugee and non-refugee populations residing in Palestine.

METHODS

The Technology Acceptance Model was used to examine determinants that influence mHealth user acceptance. Twelve dyadic or focus group semi-structured interviews (n=32) were conducted among Palestinian adolescents and parents recruited through stratified cluster sampling from 4 refugee camps, villages, and cities in Palestine. Interviews were transcribed, translated, and analyzed using inductive thematic analysis.

RESULTS

Participants included 13 families [i.e., n=32) parents, grandparents, and children] from refugee camps (n=14), villages (n=10), and cities (n=8) across the region from diverse professional backgrounds. The following themes were identified: Benefits include improved 1) access to care living under military occupation, 2) real-time health monitoring during stressful encounters due to military occupation, 3) remote health monitoring of self and family members, and 4) health promotion and disease prevention. Barriers include: 1) mHealth weaponization by the Israeli government, 2) lack of resources needed to utilize mHealth, 3) concerns for mHealth validity, and 4) lack of adoption and parameterization by local health professionals. Considerations for a successful mHealth intervention include: 1) mHealth personalization by health outcome, 2) transdisciplinary collaboration and adoption, 3) affordability and validity of tools, and 4) user-education and friendliness.

CONCLUSIONS

Adolescents and parents recognize the potential benefits of mHealth for self-management and are open to engaging in such interventions. However, it's essential to adapt these interventions to cultural, historical, and geopolitical contexts to avoid potential risks based on their living circumstances.

CLINICALTRIAL

Not applicable. Not a clinical trial
Virtual Reality (VR) Game Design for Children with Type 1 Diabetes: Clinical Expert Qualitative Study (Preprint)
Authors: Quinones Jessica , Nally Laura M , Hieftje Kimberly , Marks Asher , Turek Carolyn , Ash Garrett I
Published: February 2025

BACKGROUND

Type 1 Diabetes (T1D) is one of the most common chronic conditions diagnosed during childhood. When a child is first diagnosed with T1D the parent is the primary manager of the condition, the responsibility begins to switch over to the child during adolescence. Resources to help children with T1D begin to learn about managing during pre-adolescence (8-12 years) will allow them to practice diabetes management skills. By applying serious game mechanisms to virtual reality (VR), it creates an opportunity for pre-adolescents with T1D to practice managing diabetes in a safe and virtual environment.

OBJECTIVE

The goal of this paper was to interview clinical staff to identify themes of T1D management skills for pre-adolescents and to utilize their expertise for designing a skill building VR game.

METHODS

We conducted 30-minute interviews with 9 clinical staff who manage pediatric patients with T1D to better understand their perspectives about the transition process and their experiences with engaging with diabetes technology. To identify common themes and ideas, the interview data was transcribed, and a pattern coding technique and thematic analysis were applied.

RESULTS

Three common themes emerged from the data. The first theme was that peers can influence medical adherence. Secondly, youth naturally seek autonomy and independence during the pre-adolescence years. Lastly, parental interactions impact transition style. Clinical staff suggested personalized gaming options, multi-functionality of avatars, skills, scenarios, and data sharing.

CONCLUSIONS

Serious games for VR during the pre-adolescent years may allow youths to build a skill set and open conversations on how virtual reality technology can promote adherence to personalized treatment plans in pre-adolescent youth with T1D. Our results lend support that games should include a first-person avatar interacting with other characters, which would contribute components of autonomy and relatedness to the skill-building competency featured in existing T1D serious games.
Synthesis of CuO Nanoparticles from Copper(II) Schiff Base Complex: Evaluation via Thermal Decomposition
Authors: Al-Khazraji Ali Mudher Abdulkareem , Waheed Enass Jasim , Ahmed Awf Abdul Rahman
Published: February 2025

Copper oxide (CuO) nanoparticles were synthesized through the thermal decomposition of a copper(II) Schiff-base complex. The complex was formed by reacting cupric acetate with a Schiff base in a 2:1 metal-to-ligand ratio. The Schiff base itself was synthesized via the condensation of benzidine and 2-hydroxybenzaldehyde in the presence of glacial acetic acid. This newly synthesized symmetric Schiff base served as the ligand for the Cu(II) metal ion complex. The ligand and its complex were characterized using several spectroscopic methods, including FTIR, UV-vis, 1H-NMR, 13C-NMR, CHNS, and AAS, along with TGA, molar conductivity and magnetic susceptibility measurements. The CuO nanoparticles were produced by thermally decomposing the complex at 800 °C. These nanoparticles and other metal oxides are highly valued in various industries for their optical, magnetic, and electrical properties. The experiment highlighted the synthesis of CuO nanoparticles through the thermal breakdown of copper(II) ions, starting with copper acetate, which reacted with the ligand to form the complex. The characterization results of CuO nanoparticles reveal a highly pure crystalline structure with an average size of 70–90 nm.
Gendered Spaces: A Critical Exploration of Transgender Identity and Gender Discrimination in Arundhati Roy's “The Ministry of Utmost Happiness”
Authors: Gopaladhas Shimna
Published: February 2025

This paper explores the concept of gendered spaces in Arundhati Roy’s “The Ministry of Utmost Happiness”, focusing on the experiences of transgender individuals and the systemic gender discrimination prevalent in contemporary Indian society. Roy’s depiction of spaces—both physical and metaphorical—reveals how gender constructs marginalise and alienate individuals, particularly those who exist outside traditional gender binaries. This article examines the intricate relationships between gender, space, and identity as reflected in Roy’s narrative, offering critical insights into the struggles and resilience of marginalised communities.
intensity of using TikTok social media as a mediator of self-esteem and body image in adolescents
Authors: Rahmalia Marsa Nabila , Laili Latifatul
Published: February 2025

In the rapidly developing digital era, social media such as TikTok have become a part of adolescents' lives and have the potential to influence perceptions of body image. The intensity of TikTok use in adolescents has the potential to mediate the relationship between self-esteem and body image, as this platform is often a space for self-exploration and social comparison. This study aimed to determine the intensity of TikTok's social media use in mediating self-esteem and body image in adolescents. This study used a quantitative approach with a purposive sampling technique. The participants comprised 202 male and female adolescents aged 13 to 18 who completed the Multidimensional Body-Self Relations Questionnaire (MBSRQ-AS), the Rosenberg Self-esteem Scale (RSES), and the intensity of the TikTok social media use scale. Furthermore, a mediation analysis was conducted using Hayes' PROCESS 4 model. The results showed that self-esteem directly impacted adolescents' body image (β = 1.1324; p = 0.0000; and CI = 0.9414 - 1.3233). This finding emphasizes the role of self-esteem in adolescents' body image.
Enhancing academic engagement: Growth mindset and academic buoyancy in emerging adulthood
Authors: Fatimah Siti , Suharsono Yudi
Published: February 2025

Academic engagement is key for students' academic success, life satisfaction, and overall student well-being. Emerging adult students often face various pressures that significantly influence their AE. This study aims to explore the mediating role of AB in the influence of a GM on AE among emerging adults. The study engaged with 314 students selected through convenience sampling. The instruments used were the GM Inventory, AB Scale, and Ultra-Short Utrecht Work Engagement Scale for data collection. The data were analyzed through Structural Equation Modeling using AMOS software. The findings demonstrated a positive and significant correlation between a GM and both AB and engagement. Notably, AB was found to significantly influence AE and played a substantial mediating role in the relationship between a GM and AE. The implications of these findings indicate that institutions should implement support programs aimed to enhancing AB and fostering a GM among students, thereby improving their AE, considering the complexity of interactions among these factors.
The Fundamental Policy of the Allied Powers on the Postwar Disposition of Japanese Territories and the Status of Dokdo: Based on the Views of the Korean and Japanese Governments in the 1950s-60s
Authors:   Wonkwang University Legal Research Institute has, Hong Seong Keun
Published: February 2025

This paper examines the fundamental policy of the Allied Powers regarding the postwar disposition of Japanese territories and evaluates how the status of Dokdo should be interpreted in this context. The postwar territorial settlement of Japan by the Allied Powers was ultimately finalized through the San Francisco Peace Treaty, but Dokdo was not explicitly mentioned in Article 2 of the territorial provisions. In this regard, South Korea and Japan have taken opposing positions on the interpretation of key documents, including the Cairo Declaration, SCAPIN-677, and Article 2 in the San Francisco Peace Treaty.
From 1953 to 1965, the Korean and Japanese governments exchanged diplomatic documents concerning Dokdo. The Japanese government issued four statements on Dokdo beginning on July 13, 1953, and the Korean government responded with four rebuttal documents. These exchanges clarified the arguments and issues surrounding the claims to Dokdo, particularly the question of how Dokdo was addressed in the process of the Allied Powers' postwar disposition of Japanese territories. This question emerged as one of the main points of contention. Subsequently, there were no further detailed discussions between the two governments regarding the fundamental policy of the Allied Powers on Japanese territories and Dokdo's status. The positions of both governments on this issue remain largely unchanged from the debates of the 1950s and 1960s.
This study aims to analyze the arguments and rebuttals exchanged between the Korean and Japanese governments during the 1950s and 1960s, focusing on one key issue: “What was the fundamental policy of the Allied Powers on the postwar disposition of Japanese territories, and how should Dokdo's status be interpreted accordingly?” Based on this analysis, the study examines a series of documents, from the Cairo Declaration, which marked the Allied Powers' initial resolution on the postwar disposition of Japanese territories, to the San Francisco Peace Treaty, considering their interrelations. It seeks to interpret these documents in a coherent and integrated manner within the overarching context of the Allied Powers' postwar territorial policy. Through this approach, it aims to confirm that Dokdo was separated from Japanese territory in 1945.
Import substitution in potato production – ways to solve the problem in the Far East
Authors:   Far Eastern State Agrarian University, Shchegorets Olga V. , Volkov Denis I. ,   Federal Scientific Center for Agricultural Biotechnology of the Far East named after A. K. Chaika, Gisyuk Alexander A. ,   Federal Scientific Center for Agricultural Biotechnology of the Far East named after A. K. Chaika, Sokolovsky Evgeniy V. ,   Peasant Farm "SEV"
Published: February 2025

The self-sufficiency of the Far East with potatoes has significantly
decreased. Foreign varieties account for more than 60%. In this regard, the authors
consider the problem of import substitution in potato farming in the Far East. The
solution to the problem is presented in the development of potato varieties breeding.
It is noted that in the Amur region, new breeding and retro varieties of Primorsky
selection have been agroecologically evaluated. High productivity was noted in the
varieties Poseidon, Moryak, Orion, which are offered for seed production and commercial production.
Innovative methods of teaching at universities in the study of management and economic disciplines
Authors:   Far Eastern State Agrarian University, Malkhasyan Zarui P. , Gorlov Alexander V. ,   Far Eastern State Agrarian University
Published: February 2025

The article examines the importance of innovative teaching methods and their impact on the development of managerial and economic disciplines by students. The competencies of the future, which are necessary for students in their professional activities, are revealed. The main active learning methods used by teachers in their disciplines are reflected.
Atf4 protects islet β-cell identity and function under acute glucose-induced stress but promotes β-cell failure in the presence of free fatty acid
Authors: Yagan Mahircan , Najam Sadia , Hu Ruiying , Wang Yu , Dickerson Mathew , Dadi Prasanna , Xu Yanwen , Simmons Alan J. , Stein Roland , Adams Christopher M. , Jacobson David A. , Lau Ken S. , Liu Qi , Gu Guoqiang
Published: February 2025

Glucolipotoxicity, caused by combined hyperglycemia and hyperlipidemia, results in β-cell failure and type 2 diabetes via cellular stress-related mechanisms. Activating transcription factor 4 (Atf4) is an essential effector of stress response. We show here that Atf4 expression in β-cells is minimally required for glucose homeostasis in juvenile and adolescent mice but it is needed for β-cell function during aging and under obesity-related metabolic stress. Henceforth, Atf4-deficient β-cells older than 2 months after birth display compromised secretory function under acute hyperglycemia. In contrast, they are resistant to acute free fatty acid-induced dysfunction and reduced production of several factors essential for β-cell identity. Atf4-deficient β-cells down-regulate genes involved in protein translation. They also upregulate several lipid metabolism or signaling genes, likely contributing to their resistance to free fatty acid-induced dysfunction. These results suggest that Atf4 activation is required for β-cell identity and function under high glucose. But Atf4 activation paradoxically induces β-cell failure in high levels of free fatty acids. Different transcriptional targets of Atf4 could be manipulated to protect β-cells from metabolic stress-induced failure.
Application of a physics-informed hybrid model with additional output constraints for the prediction of the threshold of deep-penetration laser welding
Authors: Jarwitz Michael , Michalowski Andreas
Published: February 2025

The quantitative prediction of process constraints, such as the threshold of deep-penetration laser welding, plays a crucial role for the fast and reliable development of robust process windows for laser manufacturing processes. A physics-informed hybrid model with additional output constraints for the prediction of the threshold of deep-penetration laser welding is presented. A “residual model” approach is used, where a machine learning model, employing Gaussian processes, is used to model and compensate for the deviations between experiments and a physical model, and output warping is used to incorporate additional output constraints into the model. The main benefits that result from applying such a model are found to be (1) an increased prediction accuracy compared to only using the physical model, leading to a reduction of the mean relative error of about 76%; (2) a reduction of the number of required training data compared to only using a black-box machine learning model; (3) an increased prediction accuracy compared to only using a black-box machine learning model; (4) and an increased compliance with physical boundary conditions by applying the additional output constraints.
Pengembangan Skrining dan Deteksi Dini Kanker Kolorektal Secara Non-Invasif
Authors: Yusra Yusra
Published: February 2025

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Percepções dos profissionais da coordenação dos cursos de formação de Oficiais do Corpo de Bombeiros e da Polícia Militar do Maranhão em relação à inclusão de pessoas com deficiência
Authors: Costa Chahini Thelma Helena , Costa Chahini Priscila Milena , Bottentuit Junior João Batista
Published: February 2025

Abordam-se as percepções de profissionais da coordenação dos Cursos de Formação de Oficiais do Corpo de Bombeiros e da Policia Militar do Maranhão em relação à inclusão de pessoas com deficiência. Os achados deste estudo revelam que os cursos de formação de oficiais BM e PM estão se ajustando às questões que envolvem as aptidões físicas das pessoas com deficiência, suas necessidades de atendimento educacional especializado e/ou de adequações, seus potenciais e vulnerabilidades. Ainda há uma forte cultura capacitista de que pessoas com deficiência não estão aptas para desempenhar as funções militares, em específico, a de bombeiro e policial militar. Apesar do entendimento de que nem todas as deficiências se encontram aptas ao referido contexto, se faz necessário romper com a cultura do assistencialismo e com o estigma da incapacidade em relação às pessoas com deficiência, principalmente no meio militar.
Racionalismo iluminista e ethos jornalístico
Authors: Palácio de Azevedo Fábio , Capovilla Cristiano , De Castro Sena Patrícia Rakel
Published: February 2025

Este trabalho apresenta as formas como a ética iluminista influenciou a constituição do ethos jornalístico. Traçou-se, pois, um quadro da filosofia moral do Iluminismo a partir dos trabalhos de Immanuel Kant, destacando sua obra Fundamentação da Metafísica dos Costumes. Em segundo momento, mostrou-se como Jürgen Habermas desenvolveu a formulação kantiana, superando seus limites ao propor um paradigma fundado no agir comunicativo. Em seguida acessaram-se os modos pelos quais o racionalismo iluminista contribuiu para a conformação do moderno ethos da imprensa. À guisa de conclusão, pontuamos o contexto dos debates contemporâneos sobre a ética jornalística e alinhavamos observações sobre a importância dessas elaborações éticas no momento em que a imprensa sofre com o vilipêndio das tendências relativistas da chamada pós-verdade.
Geodiversidade à luz da fenomenologia:
Authors: De Assis Araújo Alves Danielle , Cordeiro Feitosa Antonio , Fernandes Silva Renan Augusto
Published: February 2025

A paisagem é dotada dos elementos naturais impregnados de relações e impressões da sociedade, no tempo-espaço do homem com as marcas da cultura e da identidade. A paisagem do Quilombo de Itamatatiua, situado no município de Alcântara, é marcada por elementos da geodiversidade e da biodiversidade em relação intrínseca com as atividades humanas manifestadas através da cultura tradicional e das práticas religiosas, artísticas e de lazer, como a festa de Santa Tereza d’Ávila. Com o objetivo de compreender a importância dos elementos da geodiversidade para a comunidade, oestudo foi baseado no método fenomenológico, abordando a compreensão da importância dos elementos abióticos utilizados para a produção ceramista e sua relação com as artesãs e os demais moradores da comunidade. Os elementos da natureza, apropriados pelas artesãs e utilizados na produção de cerâmica, com destaque para a argila, integram o conjunto da geodiversidade. Com o aporte teórico da fenomenológica, compreende-se que os elementos da natureza, moldados pelas gerações, dotados de história, tradição, cultura, experiência, entre outros atributos, ganham significados para atividades produtivas econômicas, de uso cotidiano, integrando a formação da identidade e fortalecendo a resistência do quilombo.