bluuebunny/crossref_metadata_2025 huggingface dataset:
EVALUASI MUTU BETON PADA STRUKTUR SILO CEMENT GRINDING PLANT CIGADING
Authors: A. Suryadi Suhariyanto,
Published: April 2021

Untuk mengetahui mutu beton pada struktur silo Cement Grinding Plant Cigading, maka telah dilakukan pengujian Ultrasonic Pulse Velocity (UPV) pada pile cap dan dinding pada silo kapasitas 10.000 ton.Titik pengujian yang diambil sebagai sampel adalah 56 titik pada pile cap  dan 15 titik pada bagian bawah dinding silo.Berdasarkan pengujian yang dilakukan dapat disampaikan bahw untuk pile  cap, sekitar 93 % dari sampel yang diambil mempunyai kualitas kepadatan  beton yang baik sampai dengan sangat baik.  Estimasi kuat tekan beton ekivalensi kubus untuk pile cap adalah sekitar 389 kg/cm2. Untuk bagian bawah dinding silo, sekitar 87 % dari sampel yang diambil mempunyai kualitas  kepadatan beton  yang baik sampai dengan sangat baik.  Estimasi kuat tekan beton ekivalensi kubus untuk pile cap adalah sekitar  421 kg/cm2. Kata-kata kunci: mutu beton, struktur silo, ultrasonic pulse velocity
KINERJA GELAGAR FRP BERBENTUK-U DARI E-GLASS/POLYESTER TERHADAP LENTUR
Authors: Rochman Taufiq , Sugiarto Agus
Published: April 2021

Penggunaan FRP (fiber reinforced polymer) dalam bidang inovasi struktur teknik sipil telah dipelajari dan didiskusikan dan dalam waktu yang sangat singkat, FRP telah berkembang luas menjadi bahan cerdas yang siap untuk menggantikan beton dan baja. Kekurangan baja dan beton terutama dalam kasus lentur untuk bentang yang panjang berat sendirinya mendominasi dari kapasitas lentur nominal yang tersisa dan juga dominan daripada beban hidup. Banyak penelitian yang memanfaatkan FRP sebagai perkuatan jembatan lama (retrofit) yang menggunakan strip atau sistem strip prategang karbon, tapi jarang sekali yang terfokus pada aplikasi FRP secara penuh sehingga diusulkan sebuah gelagar FRP bertipe-U untuk menahan lentur. Gelagar berpenguat FRP terbuat dari serat bertipe E-glass dengan menggunakan resin polyester tak jenuh sebagai bahan matriks. Gelagar komposit dibentuk dari satu set mat uniaksial bersudut 0° dan mat biaksial yang bersudut ±45°. Penampang sayap tertarik profil-U bagian bawah mempunyai konfigurasi lay-up 17 lapis mat [±45°3/0°4/±45°3/0°4/±45°3] sedangkan bagian penampang yang lainnya mempunyai konfigurasi lay-up 9 lapis mat [±45°]9. Gelagar divariasikan pada tingginya yaitu 15 cm, 12.5 cm dan 10 cm berturut-turut untuk gelagar A, B dan C. Bentang gelagar diset sebesar 2000 mm dan beban lentur 3 titik terpusat dari 0 sampai 105kN yang diberikan secara quasi-static. Beban dan lendutan dicatat secara manual tetapi regangan dicatat secara otomatis menggunakan data aqcuisition system. Pada beban terpusat lebih dari 0 kN sampai 105 kN, diperoleh hasil dengan rerata lendutan sebesar 47 mm dan rerata regangan tarik sebesar 0.0018. Urutan lendutan dan regangan dari yang kecil sampai yang besar adalah gelagar A, B lalu C. Tetapi kerusakan geser dan tumpu lokal akibat beban terpusat dari urutan yang kerusakannya secara visual paling kecil sampai paling besar adalah gelagar C, B lalu A. Kata-kata Kunci: gelagar-U, E-glass/polyester, FRP, kinerja lentur.
PENGENDALIAN MUTU PEMBANGUNAN RUMAH SAKIT DI MOJOKERTO PROVINSI JAWA TIMUR
Authors: Yahya Romy Fansuri , , Sumardi , Novianto Dandung
Published: April 2021

The  project was undertaken by CV. Dwi Mulya Jaya with the contract price of IDR. 9,431,000,000.00 on 150 calendar days. An alternative project planning was in need to complete the project on time, cost, and qualityThe project planning included; 1) site layout; 2) traffic managemnet; 3) implementation method; 4) scheduling; 5) cost; 6) quality and 7) safety.Technical drawings, technical specifications, bill of quantity, and work unit price of Mojokerto 2016 were needed. Microsoft Exel 2013 and Microsoft Project 2007 were employed to determine the project price and scheduling.The planning results in: 1) direction kit in the front of the project, on the right side; 2) one-gate system; 3) two-zone system and cast-in-situ method; 4) on 147 calendar days; 5) at IDR 8,188,864,607.06; 6) the quality meeting the specification and Standard Operational Procedure; 7) applying safety rules on  Mondays.  Keywords: project planning, site layout, implementation method.
ANALISIS KINERJA BETON NORMAL DAN BETON DENGAN SEMEN SUBSTITUSI BLAST FURNACE SLAG
Authors: Akhmad Suryadi Tri Septa A.D., Qomariah,
Published: April 2021

The use of steel smelting waste industry is used to reduce the waste overflow at the site. The waste steel smelting industry called blast furnace slag (BFS) used as a substitution for cement in a concrete mixture in a Laboratory Material Test, Civil Engineering State Polytechnic of Malang. The purpose of this analysis is to: 1) Test the workability of normal concrete and concrete with BFS; 2) Find out compressive strength of each concrete; 3) Compare the price to both concrete in the construction of building.The required data were of gradation of aggregate, water content of aggregate, density of aggregate, absorption of aggregate, bulk density of aggregate, fineness of cement, normal consistency of cement, cement setting time, compressive strength of mortar cement, and the price of building materials Surabaya 2016. SNI 03-2834-2000 method was applied with variations BFS substitute of cement are 0%, 10%, 15%, 20%, and 30% BFS and the planned compressive strength obtained at 28 days of 300 kg/cm2.The analyses result in 1) The workability of each concrete: 5.75cm of normal concrete (0%), 3.45cm, 3.15cm, 3.1cm, and 3.05cm respectively with BFS concrete; 2) The compressive strength of each concrete at 28 days: 235.56kg/cm2 of normal concrete, 105.33kg/cm2, 138.96kg/cm2, 127.26kg/cm2, and 94.52kg/cm2respectively with BFS concrete; The use of BFS cannot be applied to the concrete mixture, because of low compressive strength; 3) For the price of concrete materials per m3 are IDR 999.472,05 of normal concrete, IDR 996.926,78 for 10% with BFS, IDR 995.654,93 for 15% with BFS, IDR 994.381,50 for 20% with BFS, and IDR 991.837,80 for 30% with BFS. Keywords: BFS, workability, compressive strength
Pengaruh Penyediaan Jalur Khusus Sepeda Diatas Badan Jalan (Sky Road) Terhadap Kinerja Jalan Di Kota Malang (Studi Kasus Jalan Borobudur – Soekarno Hatta) P2M Politeknik Negeri Malang Tahun 2018
Authors: Marjono Marjono
Published: April 2021

Abstract :One of the problems felt by the people of Malang City is the problem of congestion and traffic system irregularities. Borbudur -Soekarno Hatta road, including roads that experience traffic problems, namely frequent traffic jams, especially at the time of departure or return to school, and hours of departure and return to work, this is because the road is the road access to the education area , trade and one of the access roads that lead to the center of Malang City. If this is not done immediately, the traffic problems will increase. A possible alternative to overcome this problem is to reduce motorbike users entering the road, by diverting some motorbike users to non-motorized bikes (bicycles) primarily for purposes of educational facilities, by providing special lanes for bicycles, which above the road (Sky Road). From the results of the analysis it can be seen that by providing a Bicycle Special Path above the Road Body (Sky Road), it can reduce the value of degree of saturation (DS) and can increase the level of service from C to B. Estimated cost of the main Sky road structure Rp. 9. 236,308 000 ,, - (Nine Billion Two Hundred Thirty-Six Million Three Hundred Eight Thousand Rupiahs) Keywords: special bike lanes, sky road, road performance
PEMODELAN DINDING CANTILEVER PENAHAN TANAH MENGGUNAKAN SAP 2000 DENGAN MENGANALISA KUAT TEKAN TERHADAP VARIASI BEBAN (STUDI KASUS DI RUAS JALAN BALEROJO KALEGEN)
Authors: Sihombing Jefrizal , I Yoga Satria , Putri Amelia Rosana , Utama Widya
Published: April 2021

The modeling of retaining wall is adapted to the real conditions on Balerejo Kalegen Street. This wall modeling uses a Cantilever type wall which has a height of 550 cm and a width of 385 cm which is useful for calculating the minimum strength of a cantilever wall for retaining the soil on the Balerejo Kalegen road. In addition, this wall is modeled to have a width of 55 cm, a heel width of 130 cm, a foot width of 130 cm, the width of the next leg is 100 cm, with a wall that enters it is 50 cm and using evenly distributed load variations has been adjusted where the load used is the burden amounting to 11,138, 5.5, 0.3869 tons. When inputting data into SAP 2000 beforehand, calculations must be made related to the force that will affect the wall, then modeling the walls according to the Cantilever shape. After that, Cantilever wall that has been made can be calculated compressive strength and shear strength where the compressive strength of the front wall with an average of 175,154 tons m, the back with an average of 62,666 tons m, the average front heel 866,054 tons m , and the back heel averages 910,463 tons m. Keywords: Cantilever, Retaining Walls, SAP 2000.
STUDI KELAYAKAN MATERIAL GUNUNG DAERAH ALIRAN SUNGAI ARAH MALANG-KOTA BATU DALAM PENGGUNAANNYA SEBAGAI SALAH SATU MATERIAL BETON
Authors: Naibaho Armin , Sugiarto Agus , Dewi Purnama
Published: April 2021

Abstract The use of the mountain seal used as a building block for concrete should be considered, based on current usage apart from being a light construction material for housing, mountain materials from these two places are used as the main aggregate material for building construction, water structures (dams), roads. and bridges located in the surrounding Malang-Kota Batu area To determine the size of the aggregate, the coarse aggregate is sieved using a vibrating sieve, while the fine aggregate is sieved by a hydraulic sieve. In the screening process, about 70% of the filtered must pass so that high efficiency and capacity can be achieved. The compressive strength test results obtained the average compressive strength value at 28 days of concrete for concrete with fine aggregate sand zone III and coarse aggregate (gravel) in the Batu City area is equivalent to 35.65 MPa. The results of the split tensile strength test showed that the average split strength value at the age of 28 days for concrete with fine aggregate sand zone III and coarse aggregate (gravel) in the Kota Batu area is equivalent to 2.51 MPa. The compressive strength value for normal concrete is 35.65 MPa, it should produce split tensile strength = 4.179 MPa according to the provisions of SNI T-15-1991-03 Article 3.2.5 (fr = 0.70√fc '). Even though the split tensile strength value obtained in the laboratory is only 2.51 MPa, this means that the quality of materials (sand and broken stone) from Batu City is not suitable for use as building materials. Because the number 2.51 MPa is relatively much smaller than the value of 4.179 MPa, it is only one of the factors outlined in the SNI T-15-1991-03 article 3.2.5. Keywords: Mountain Material, Concrete, Concrete Compressive Strength Test, Concrete Tensile Strength Test
PEMODELAN JEMBATAN RANGKA DENGAN KOMBINASI TIPE RANGKA DITINJAU DARI LENDUTAN DAN BERAT JEMBATAN
Authors: Al Ansyorie Mohammad Musthofa , Kirom Mustofa Mohammad Alfin , Firdaus Sabila Madih Tahtal , Putri Nadia Mulia
Published: April 2021

Abstract The frame bridge structure has several types of frames, each of which has advantages in accordance with its application. Several studies have shown that the comparison between one frame type and another has the advantage of different strengths. In this study an analysis will be carried out by modeling the modified bridge structure truss type and combined with other types to obtain a structure that has the best strengths. The method used in this study is to model the bridge structure with the help of SAP2000 v20 software. The analysis process in this modeling refers to SNI 1725: 2016 concerning load on bridges, BMS (Bridge Management System) in 1992, and several related regulations. The results of modeling analysis show that the K-truss frame is the best frame by looking at the aspect ratio of the bridge, namely the ratio between deflection and weight of each type. The combination of the K-truss frame type and the warren frame type is the best combination of frame types based on the best deflection and weight values. The deflection value for this type of frame combination is -0.416 mm and the ratio value is 6.017. Keywords: modeling, truss bridge, k-truss, combine
INFLUENCE OF INTERNAL LABOR FACTORS ON WORK ACCIDENTS OF XX TOLL ROAD CONSTRUCTION PROJECT
Authors: Riskijah Sitti Safiatus
Published: April 2021

Abstrak The XX Toll Road Construction Project is a national project with high risk and high complexity, given the nature of the work that requires clearing new land on hills and valley areas which requires retaining wall works. During its implementation, work accident occurence can be caused by many factors, including labor factors. This study aims to determine the effect of internal labor factors on work accidents occurred at XX Toll Road Construction Project. The data required in the form of primary data obtained from questionnaires about occupational safety and health, and fitness measurements using the Balke method. The data analysis used Multiple Regression analysis with SPSS. The results showed that the internal factors of the workforce, namely the factors of work safety, occupational health, and workforce fitness simultaneously have strong and significant effect on the occurrence of work accidents in the project. Hence, these internal factors partially bring significant effect. Keywords: labor, safety, health, fitness, accidents
Eksperimen Gabungan Uji Lentur dan Implementasi Teori Wheatstone Bridge untuk Mengetahui Kekuatan Lentur dan Modulus Elastisitas Material Reng Baja Ringan
Authors: Ardika I Nyoman , Suardika I Nyoman
Published: April 2021

Abstract Lightweight steel battens are one of the elements roof frame structure buildings. The material that is widely used today is mild steel. To get optimal results use be lightweight steel battens can be done through a structural analysis. In the analysis structure of light steel battens, required the actual dimensions of the cross-section and strength the light steel battens. The actual dimensions of the cross sections are obtained by direct measurement, and strength is obtained through a laboratory testing process either tensile testing or bending testing. This research was conducted by combining the application of Wheatstone Bride theory and bending testing in determining the strength and modulus of elasticity of mild steel battens on eleven test samples of mild steel battens with a length of 600 mm each. The test result data is in the form of load relationship with voltage changes generated from the Wheatstone Bridge network on a multimeter reading connected to the Wheatstone Bridge network. The data processing of the result of the change in voltage test will produce strain, so that the load and strain relationship is obtained. Data analysis of load relationship with stretching and the load-stress relationship will describe the strain-stress relationship. From the results of data processing, the results of the research conducted were obtained yield stress (fy) 407.8739 MPa at 0.2% strain; allowable stress (fa) 271,916 MPa at 0.1333% strain; ultimate stress (fu) 616,094 MPa at a strain of 0.3021%; and Modulus of elasticity (Es) 203921 MPa. Keywords:Mild Steel, Strain, Wheatstonebridge, Stress
IMPLEMENTASI FUZZY AHP DAN TOPSIS PADA PEMILIHAN METODE PEKERJAAN PERKERASAN KAKU
Authors: Broto Agung Budi , Maharani Ester
Published: April 2021

Abstract Rigid Pavement is the main work in toll road construction. In the implementation of rigid pavement, there are several alternatives, namely mechanical and conventional, where each alternative has advantages and disadvantages. This study aims to determine the selection of appropriate work methods on the Kunciran - Cengkareng Toll Road Project. Many multi-criteria must be considered, the consideration of decision making can be done by using the Technique For Others Preference By Similarity To Ideal Solution (TOPSIS) method and Fuzzy Analytical Hierarchy Process (FAHP) which can give weight to the specified criteria. The objectives of this study are: (1) to find out the most influential criteria as a basis for considering the selection of methods for implementing rigid pavement works. (2) to determine the method of implementing rigid pavement work that is appropriate by the existing criteria. This study uses a questionnaire survey. The results of this study indicate that the criteria for quality of work are the most influential criteria with a value of 0.351, then the implementation time criteria (0.201), the criteria for work costs (0.150), work safety criteria (0.133), work volume criteria (0.084), implementation process criteria (0.049), and the last is the implementation preparation criteria (0.032). The appropriate alternative used for the rigid pavement method is the mechanical method with a value of 0.621, while the mechanical method only reaches the values of 0.379.. Keywords: Fuzzy AHP; Perkerasan Kaku; TOPSIS.
Perilaku Retak Pelat Beton Bertulang Akibat Beban Statik
Authors: Agoes Soehardjono, Achfas Zacoeb Fitrayuddin,
Published: April 2021

Masalah lebar retak merupakan hal yang masih memerlukan penelitian lebih lanjut, kajian riset tentang lebar retak, baik dari teori klasik sampai sekarang masih dibahas dalam sejumlah artikel jurnal. Adapun maksud penelitian ini adalah membuktikan lebar retak komposit pelat dengan variasi tulangan akibat beban statik. Pengujian ini menggunakan pelat dengan ukuran 170x60x20 cm diletakkan diatas tumpuan sederhana. Beban diberikan secara bertahap sampai mencapai retak yang diijinkan (ACI committee 224) sebesar 0,4 mm, benda uji dibuat sebanyak 6 benda uji masing-masing 3D13, 4D13, 5D13, 6D13, 5D16, 6D16. Dari 6 benda uji yang diteliti dapat diuraikan bahwa setelah mencapai retak awal, penambahan beban dilakukan tiap 1 kN agar data yang diperoleh lebih akurat. Kaitannya dengan spasi tulangan, perambatan retak lebih lambat sesuai dengan spasi tulangan pada masing-masing benda uji. Dengan kata lain dapat disimpulkan bahwa semakin banyak tulangan yang dipasang (ρ semakin besar) maka lebar retak maksimum semakin kecil. Berdasarkan grafik hubungan antara tegangan baja dan lebar retak antara eksperimen, peraturan dan peneliti ternyata bahwa pengaruh angka tulangan ρ pada beban statik adalah: 1.Hasil peraturan dan peneliti relatif lebih linier dibandingkan dengan eksperimen. 2. Hasil eksperimen lebih besar dibandingkan dengan hasil peraturan dan peneliti, hasil peraturan lebih kecil dari hasil peneliti. 3. Retak awal pada peraturan dan peneliti lebih cepat dibandingkan dengan hasil eksperimen tetapi perambatan retak eksperimen lebih cepat dari hasil peneliti dan peraturan. Kata-kata kunci:  lebar retak, beban statik, tegangan baja.
Pengaruh Implementasi Rencana Tata Ruang Wilayah Terhadap Konservasi Sumber Daya Air Pada Wilayah Studi Kota Batu Jawa Timur
Authors: M.Bisri, Agus Suharyanto Puspa Permanasari,
Published: April 2021

Penelitian ini bertujuan untuk mengevaluasi penggunaan lahan kondisi eksisting tahun 2010 dengan rencana dalam implementasinya pada Rencana Tata Ruang Wilayah Kota Batu tahun 2003 – 2013 dan menentukan pengaruh penggunaan lahan terhadap konservasi sumber daya air di kota Batu. Metode yang digunakan dalam penelitian ini adalah analisis regresi dan Analisis Proses Heirarki (AHP). Penelitian ini menunjukkan terdapat pengaruh dominan pada penggunaan lahan terhadap konservasi sumber daya air dan mempunyai hasil analis berbeda tiap kecamatan, penurunan nilai infiltrasi terjadi di kecamatan Junrejo sebesar 3 % dan kecamatan Batu sebesar 6%, hal berbeda terjadi di kecamatan Bumiaji, dengan peningkatan nilai infiltrasi sebesar 9%. Secara keseluruhan, besaran daya resap air hujan Kota Batu mengalami peningkatan sebesar 34.587.662 m³/tahun atau 15,9%, disebabkan peningkatan besaran curah hujan dan berhasilnya  program penghijauan. Peningkatan infiltrasi di Kota Batu merupakan pengaruh dari peningkatan daya resap air hujan di kecamatan Bumiaji yang meningkat sebesar 46.065.437 m³/tahun atau 31,7%, dengan kontribusi sebesar 76% terhadap total infiltrasi di Kota Batu. Kata-kata kunci:  konservasi, penggunaan lahan, infiltrasi
Pengaruh Penggunaan Alat Bantu Pasang Spesi (ALPI) Pada Pemasangan Dinding Bata Merah Sistem ½ Batu
Authors: Trijanto Djoko
Published: April 2021

Makalah ini menyajikan hasil penelitian yang bertujuan untuk meningkatkan kecepatan dan efisiensi  volume pemakaian adukan spesi/mortar pada pemasangan dinding bata merah sistem ½ batu. Jumlah sampel diambilkan dari hasil praktek mahasiswa jurusan Teknik Sipil Politeknik Negeri Malang sebanyak 20 mahasiswa yang terbagi 10 orang memakai ALPI dan 10 orang tanpa menggunakan ALPI. Hasil penelitian menunjukkan adanya peningkatan kecepatan 1,45 kali dan efisiensi volume spesi sebesar 29,9 %. Hasil ini menunjukkan bahwa dengan penggunaan ALPI berpengaruh besar terhadap kecepatan dan efisiensi volume pemakaian adukan spesi pada  pemasangan dinding bata merah sistem ½ batu. Kata-kata kunci:  spesi,kecepatan, efisiensi, ALPI
PENYUSUNAN PROJECT PLANNING PERBAIKAN TANAH LUNAK DENGAN PREFABRICATED VERTICAL DRAIN (STUDI KASUS PADA AREA LONG BEACH PAKUWON CITY-SURABAYA)
Authors: Amin Fahmi Muhammad
Published: April 2021

The improvement project was carried out within 30 work days with the project price of IDR 551.439.500,-. In the project management a project planning is in need a carry out the project on time at precise cost and quality. The data needed in this arrangement of project planning were contract documents, list of work force cost, equipment and materials used. Work scheduling and cost arrangement for the project was done with benefit of Microsoft Project Program. The writer discusses the determination of project site layout, traffic management, implementation method, project time schedule, project cost planning, project quality management planning as well as K3 program planning. From the calculating result, the writer summed that the total cost was Rp. 270.950.000.-. When this sum compared to the previous project cost planning was Rp. 551.439.500,- we can difference as much as Rp. 280.489.500.-. In order to assure the working quality, material testing was conducted in laboratory so that the material mounted matched the technical qualifications as well as the use if correct implementation method. To avoid work accident, every worker must use the Self Protection Device and work carefully by the correct working procedures. Keywords:  Vertical Drain, Soft Clay, Project Planning
ANALISA FINANSIAL PROYEK PEMBANGUNAN JALAN TOL AA DI JAWA TIMUR
Authors: Kusuma, Marjono, Fauziah S.C.S Maisarah Adham Indra
Published: April 2021

One attempt to create a good transport system is the construction of new roads toll roads. A toll road construction soon to be implemented is AA segment a which is of  investment oriented and expected to give profits to the investors. According to the plan, the toll road is 40.5 km long development is divided into 4 sections. Data required to perform financial analysis is the cost of investment, operation and maintenance cost, traffic volume, and the toll rate plans. These data to find the values of the parameters used to calculate the financial analysis include the Net Present Value (NPV), Internal Rate of Return (IRR), Benefit Cost Ratio (BCR), and Payback Period (PP). The financial analysis will use two funding alternatives, alternative I using 100% equity, alternative II using 30% equity and 70%  loan. The purpose of this study is to determine the results of the financial analysis of the parameter values of highway construction project feasibility and determine the most influential factors after a sensitivity analysis has been made. Based on the financial analysis the investment cost results in IDR 3,827,698,222,645. The financial analysis NPV parameters alternative I results in IDR 661,439,934,962 and alternative II in IDR 230,334,925,350 which means they are feasible because both NPVs are greater than 0; both the IRR of 14.18% for alternative I and 13.02% for alternative II are greater than Minimum Attractive Rate Of Return (MARR) value of 12.42%; so, they are feasible; the value of BCR of alternative I is of 1.13 and alternative II is of 1.04; so, they are feasible because the value of BCR is greater than 1. While the PP of alternative I in the period of 12.1 years and alternative II in the period of 13.5 years. The sensitivity analysis of alternatives I and II result in  the most influential alternative—when construction period experiences ≥ 3 years backwards.Keywords: investment cost, financial analysis, sensitivity analysis.
PENGARUH KEMACETAN DI SIMPANG SABILILLAH TERHADAP IMPLEMENTASI CITRA LALU LINTAS DI SIMPANG PROGRESIF
Authors: Dwi Ratnaningsih, Rudy Ariyanto Supiyono,
Published: April 2021

Progress of a country in line with the progress of traffic (transport). Fluency in traffic is determined by the smoothness of traffic on the road. Problems often arise on the highway is congestion at the intersection. Neither was signalized intersections and signalized intersections. Problems at the intersection is less accuracy green flame at the intersection with the number of vehicles in a segment. A road with high traffic volume vehicle green flame low while other road traffic volume small green flame length. So in a long queue roads, while other roads are deserted while still green flame.     This study aims to minimize the occurrence of conflic at the intersection of green flame. Research will make iterations in the intersection, where a road section which will be nominated densely green flame, the flame of the green according to the volume of traffic on these roads. Each road will be a green flame in accordance with the volume of traffic, without having to change any program there is a change in traffic volume.The degree of saturation of the calculation obtained by ....Keywords: roads, hight traffic, progressive intersection, degree saturation
PHOTOSYNTHETIC ACTIVITY OF MIXED SEEDING OF GRASSES, THEIR PRODUCTIVITY AND INFLUENCE ON FERTILITY OF SODDY-PODZOLYC SOIL IN THE CONDITIONS OF THE UPPER VOLGA
Authors: Esedullaev Sabir
Published: April 2021

The results of long-term research on the photosynthetic activity of mixed crops of perennial grasses are presented, their productivity and the effect on the fertility of potentially poor soddy-podzolic soils are studied. It was found that in herbage based on clover, the maximum area (68.8 thousand m2/ha) and the photosynthetic potential of leaves (718 thousand m2/ha × day) on the control were formed by mixed crops of clover and festulolium, and against the background of mineral nutrition – mixtures clover with timothy (68.4 thousand m2/ha and 718) and festulolium (66.6 thousand m2/ha and 704 thousand m2/ha × day). In mixed crops with alfalfa mixtures with timothy and ryegrass, they had the highest leaf area – 57.9 and 57.5 thousand m2/ha and FP of 620 and 611 thousand m2/ha × day, respectively. A high leaf surface index was found in clover herbage with festulolium in control (6.88), timothy (6.84) and festulolium (6.66) against the background of mineral nutrition. Grass mixtures of alfalfa in productivity exceeded clover ones, the most productive on both backgrounds in terms of the yield of fodder units and protein collection turned out to be a grass mixture of alfalfa with festulolium – 7.19 in the control and 8.53 thousand / ha of fodder units when applying mineral fertilizers, 1069 and 1194 kg/ha of protein, respectively, sugar – festulolium on the control and festulolium and ryegrass on the background of mineral nutrition. The smallest amount of stubble-root residues (SRR) – 7.99, 8.32 in the control and 11.9, 14.5 t/ha against the background of mineral nutrition, respectively, accumulated grass stands of meadow clover with ryegrass and fescue due to a weak root system. The application of mineral fertilizers increased the amount of SRR in clover mixtures more strongly (by 55% on average) than in alfalfa (only by 26%), although in terms of the total amount of accumulated bio-residues, mixed crops of alfalfa exceeded clover crops – their maximum amount is 13.7 and 12.6 t/hectares on the control and 17.2, and 15.8 t/ha against the background of mineral nutrition accumulated mixtures of alfalfa with timothy and festulolium. Herbal mixtures with alfalfa accumulated more symbiotic nitrogen – from 54 to 58 kg/ha on the control and 56–74 kg/ha on the background of mineral nutrition. Mineral fertilizers significantly affected the symbiotic activity of only clover grass stands, increasing the amount of nitrogen fixed by them by 56%, and their effect on alfalfa mixtures was insignificant.
COLZA SEEDS IN THE FEEDING OF BROILER CHICKENS
Authors: Gaganov Anatoly , Zverkova Zinaida , Ishmuratov Halyaf , Osipyan Bella
Published: April 2021

In order to save soybean meal, sunflower oil and reduce the cost of rations, new sources of raw materials can be used. In modern conditions, attention is drawn to the spring colza, the seeds of which can be used as a fat and protein supplement. A limiting factor in the use in poultry nutrition is the presence of glucosinolates in the seeds and erucic acid in the oil, which negatively affect the growth and development, especially of young animals. Breeding work aimed at improving the feed qualities of spring colza seeds contributes to a wider use in the composition of diets for poultry. In growth experiments on broiler chickens the rate of introduction of seeds of spring colza of the 'Nadezhda' variety selected by the Federal Williams Research Center of Forage Production and Agroecology. It has been established that this variety belongs to the "canola" varieties, and its seeds can be included up to 7% (by weight) in the feed composition without adversely affecting the state of the body and the rate of growth of live weight of chickens. The use of colza seeds reduces the use of soybean meal to 4.7% and sunflower oil to 2.3 % (relative). Increases the efficiency of feed in the control up to 61.93% and in the experimental groups (I, II, III, IV) – 62.18, 62.51, 63.62, 62.78%, respectively. The seeds of the spring colza variety 'Nadezhda' satisfy the bird's need for nutrients and ensure equal productivity with the control
Introduction preservatives in silage feed with air
Authors: Otroshko Sergey , Marchuk Andrzej , Shevtsov Alexey , Sharikov Nikolay , Bakulin Andrey
Published: April 2021

available in liquid, viscous, and powdered form on the market of the Russian Federation, there are certain difficulties with their dosage and uniform distribution in silage feeds. This is especially important for preservatives, which are used in small doses. Abroad, this issue is solved by using applicators which allow to make low doses of preservatives in the range of 125-250 ml/t uniformly [1]. In our country, to increase uniformity of preservatives distribution, water is usually added to a small amount of preservatives and they are applied by column centrifugal or diaphragm pumps at the rate of 3–5 l/t of silage raw material. It is not possible to apply preservatives in pure form with available metering pumps, as they cannot ensure uniformity and small doses of their application. In this regard, the installation for forage harvester for fine-dispersed application of preservatives by compressed air was developed in the Federal Williams Research Center of Forage Production & Agroecology. The results of laboratory studies are presented.
Investigating Molecular Determinants of Cancer Cell Resistance to Ionizing Radiation Through an Integrative Bioinformatics Approach
Authors: Toy Halil Ibrahim , Karakülah Gökhan , Kontou Panagiota I. , Alotaibi Hani , Georgakilas Alexandros G. , Pavlopoulou Athanasia
Published: April 2021

Eradication of cancer cells through exposure to high doses of ionizing radiation (IR) is a widely used therapeutic strategy in the clinical setting. However, in many cases, cancer cells can develop remarkable resistance to radiation. Radioresistance represents a prominent obstacle in the effective treatment of cancer. Therefore, elucidation of the molecular mechanisms and pathways related to radioresistance in cancer cells is of paramount importance. In the present study, an integrative bioinformatics approach was applied to three publicly available RNA sequencing and microarray transcriptome datasets of human cancer cells of different tissue origins treated with ionizing radiation. These data were investigated in order to identify genes with a significantly altered expression between radioresistant and corresponding radiosensitive cancer cells. Through rigorous statistical and biological analyses, 36 genes were identified as potential biomarkers of radioresistance. These genes, which are primarily implicated in DNA damage repair, oxidative stress, cell pro-survival, and apoptotic pathways, could serve as potential diagnostic/prognostic markers cancer cell resistance to radiation treatment, as well as for therapy outcome and cancer patient survival. In addition, our findings could be potentially utilized in the laboratory and clinical setting for enhancing cancer cell susceptibility to radiation therapy protocols.
Topic Evolution Analysis for Omics Data Integration in Cancers
Authors: Ning Li , Huixin He
Published: April 2021

One of the vital challenges for cancer diseases is efficient biomarkers monitoring formation and development are limited. Omics data integration plays a crucial role in the mining of biomarkers in the human condition. As the link between omics study on biomarkers discovery and cancer diseases is deepened, defining the principal technologies applied in the field is a must not only for the current period but also for the future. We utilize topic modeling to extract topics (or themes) as a probabilistic distribution of latent topics from the dataset. To predict the future trend of related cases, we utilize the Prophet neural network to perform a prediction correction model for existing topics. A total of 2,318 pieces of literature (from 2006 to 2020) were retrieved from MEDLINE with the query on “omics” and “cancer.” Our study found 20 topics covering current research types. The topic extraction results indicate that, with the rapid development of omics data integration research, multi-omics analysis (Topic 11) and genomics of colorectal cancer (Topic 10) have more studies reported last 15 years. From the topic prediction view, research findings in multi-omics data processing and novel biomarker discovery for cancer prediction (Topic 2, 3, 10, 11) will be heavily focused in the future. From the topic visuallization and evolution trends, metabolomics of breast cancer (Topic 9), pharmacogenomics (Topic 15), genome-guided therapy regimens (Topic 16), and microRNAs target genes (Topic 17) could have more rapidly developed in the study of cancer treatment effect and recurrence prediction.
Regulation of Formation, Stemness and Therapeutic Resistance of Cancer Stem Cells
Authors: Jing Nan , Gao Wei-Qiang , Fang Yu-Xiang
Published: April 2021

Over the past 20 years cancer stem cells (CSCs) have been proposed as key players in the tumorigenesis and progression, which are closely related to the initiation, metastasis and therapeutic resistance of cancer. Evidences have been provided that both genetic and epigenetic factors contribute to the regulation of the formation and stemness maintenance as well as the therapeutic resistance of CSCs via affecting various signal pathways. In addition, the interaction between CSCs and tumor microenvironment has also been revealed to be involved in the above-described processes. With the aim of targeting CSCs to improve treatment outcome, we herein discuss the mechanisms that orchestrate the characteristic of CSCs by the three elements and potential therapeutic strategies. We also summarize how several key regulatory factors function in the regulation of not only the formation and stemness maintenance, but also the therapeutic resistance of CSCs. Thus, future studies focusing on these key factors would be helpful for the development of novel drugs targeting CSCs.
Mitochondria Donation by Mesenchymal Stem Cells: Current Understanding and Mitochondria Transplantation Strategies
Authors: Gomzikova Marina O. , James Victoria , Rizvanov Albert A.
Published: April 2021

The phenomenon of mitochondria donation is found in various tissues of humans and animals and is attracting increasing attention. To date, numerous studies have described the transfer of mitochondria from stem cells to injured cells, leading to increased ATP production, restoration of mitochondria function, and rescue of recipient cells from apoptosis. Mitochondria transplantation is considered as a novel therapeutic approach for the treatment of mitochondrial diseases and mitochondrial function deficiency. Mitochondrial dysfunction affects cells with high energy needs such as neural, skeletal muscle, heart, and liver cells and plays a crucial role in type 2 diabetes, as well as Parkinson’s, Alzheimer’s diseases, ischemia, stroke, cancer, and age-related disorders. In this review, we summarize recent findings in the field of mitochondria donation and mechanism of mitochondria transfer between cells. We review the existing clinical trials and discuss advantages and disadvantages of mitochondrial transplantation strategies based on the injection of stem cells, isolated functional mitochondria, or EVs containing mitochondria.
The Transcription Regulator Patz1 Is Essential for Neural Stem Cell Maintenance and Proliferation
Authors: Mancinelli Sara , Vitiello Michela , Donnini Maria , Mantile Francesca , Palma Giuseppe , Luciano Antonio , Arra Claudio , Cerchia Laura , Liguori Giovanna Lucia , Fedele Monica
Published: April 2021

Proper regulation of neurogenesis, the process by which new neurons are generated from neural stem and progenitor cells (NS/PCs), is essential for embryonic brain development and adult brain function. The transcription regulator Patz1 is ubiquitously expressed in early mouse embryos and has a key role in embryonic stem cell maintenance. At later stages, the detection of Patz1 expression mainly in the developing brain suggests a specific involvement of Patz1 in neurogenesis. To address this point, we first got insights in Patz1 expression profile in different brain territories at both embryonic and postnatal stages, evidencing a general decreasing trend with respect to time. Then, we performed in vivo and ex vivo analysis of Patz1-knockout mice, focusing on the ventricular and subventricular zone, where we confirmed Patz1 enrichment through the analysis of public RNA-seq datasets. Both embryos and adults showed a significant reduction in the number of Patz1-null NS/PCs, as well as of their self-renewal capability, compared to controls. Consistently, molecular analysis revealed the downregulation of stemness markers in NS/PCs derived from Patz1-null mice. Overall, these data demonstrate the requirement of Patz1 for NS/PC maintenance and proliferation, suggesting new roles for this key transcription factor specifically in brain development and plasticity, with possible implications for neurodegenerative disorders and glial brain tumors.
Carbon Purchase Agreements, Dactories, and Supply-Chain Innovation: What Will It Take to Scale-Up Modular Direct Air Capture Technology to a Gigatonne Scale
Authors: Izikowitz David
Published: April 2021

Natural and engineered carbon dioxide removal have become regular features of climate models which limit warming to 1.5°C or even 2°C above pre-industrial levels. This gives rise to an assumption that solutions, for example direct air capture (DAC)—involving the direct removal of carbon dioxide from ambient air—can be commercialised and deployed at the necessary speed and scale to have a material impact, in the order of gigatonnes, by mid-century. Modular, solid-sorbent DAC on a gigatonne scale will require the mass mobilisation of supply chains to manufacture millions of modular DAC units−20 million of the present state of the art 50 tonne/year modules to deliver 1 gigatonne per year, as well as the large-scale production of novel chemical sorbents. To achieve a climate relevant DAC industry will demand innovative procurement models, for example carbon purchase agreements (CPAs), and dedicated DAC manufacturing facilities or dactories. In addition, insight is offered through the work of DAC start-up Carbon Infinity into the industry supply-chain position, adopting lessons from computing, and energy technologies. In particular, we look at approaches to drive demand and scale-up DAC module production, and opportunities presented in the development of an integrated DAC manufacturing industry.
Wearable, Environmental, and Smartphone-Based Passive Sensing for Mental Health Monitoring
Authors: Sheikh Mahsa , Qassem M. , Kyriacou Panicos A.
Published: April 2021

Collecting and analyzing data from sensors embedded in the context of daily life has been widely employed for the monitoring of mental health. Variations in parameters such as movement, sleep duration, heart rate, electrocardiogram, skin temperature, etc., are often associated with psychiatric disorders. Namely, accelerometer data, microphone, and call logs can be utilized to identify voice features and social activities indicative of depressive symptoms, and physiological factors such as heart rate and skin conductance can be used to detect stress and anxiety disorders. Therefore, a wide range of devices comprising a variety of sensors have been developed to capture these physiological and behavioral data and translate them into phenotypes and states related to mental health. Such systems aim to identify behaviors that are the consequence of an underlying physiological alteration, and hence, the raw sensor data are captured and converted into features that are used to define behavioral markers, often through machine learning. However, due to the complexity of passive data, these relationships are not simple and need to be well-established. Furthermore, parameters such as intrapersonal and interpersonal differences need to be considered when interpreting the data. Altogether, combining practical mobile and wearable systems with the right data analysis algorithms can provide a useful tool for the monitoring and management of mental disorders. The current review aims to comprehensively present and critically discuss all available smartphone-based, wearable, and environmental sensors for detecting such parameters in relation to the treatment and/or management of the most common mental health conditions.
Levoketoconazole in the Treatment of Patients With Cushing’s Syndrome and Diabetes Mellitus: Results From the SONICS Phase 3 Study
Authors: Pivonello Rosario , Elenkova Atanaska , Fleseriu Maria , Feelders Richard A. , Witek Przemyslaw , Greenman Yona , Geer Eliza B. , Perotti Paola , Saiegh Leonard , Cohen Fredric , Arnaldi Giorgio
Published: April 2021

Background

Cushing’s syndrome (CS) is associated with numerous comorbidities, including diabetes mellitus (DM). Levoketoconazole, an orally administered ketoconazole stereoisomer, is in clinical trials for the treatment of CS.

Methods

SONICS, a prospective, open-label, phase 3 study in adults with confirmed CS and mean 24-h urinary free cortisol (mUFC) ≥1.5× ULN, included dose-titration, 6-month maintenance, and 6-month extension phases. This subanalysis evaluated the efficacy of levoketoconazole in patients with DM (n = 28) or without DM (n = 49) who entered the maintenance phase. Safety was evaluated in the overall population (N = 94) during the dose-titration and maintenance phases.

Results

Normalization of mUFC at the end of maintenance phase (EoM), without a dose increase during maintenance (SONICS primary endpoint) was observed in 46% of patients with DM (95% CI, 28 to 66%; P = 0.0006 vs null hypothesis of ≤20%) and 33% of patients without DM (95% CI, 20 to 48%; P = 0.0209). At EoM, mean HbA1c decreased from 6.9% at baseline to 6.2% in patients with DM and from 5.5 to 5.3% in patients without DM. Mean fasting blood glucose decreased from 6.85 mmol/L (123.4 mg/dl) to 5.82 mmol/L (104.9 mg/dl) and from 5.11 mmol/L (92.1 mg/dl) to 4.66 mmol/L (84.0 mg/dl) in patients with and without DM, respectively. Adverse events that were more common in patients with DM included nausea (58.3%), vomiting (19.4%), and urinary tract infection (16.7%); none prompted study drug withdrawal.

Conclusions

Treatment with levoketoconazole led to sustained normalization of mUFC and improvement in glycemic control that was more pronounced in patients with DM.

Clinical Trial Registration

(ClinicalTrials.gov), NCT01838551.
Improved Intrinsic Activity of Ce0.5Pr0.5O2 for Soot Combustion by Vacuum/Freeze-Drying
Authors: Li Qian , Su Yimin , Liu Xuesong , Lv Yanan , Zhang Nana , Xin Ying , Zhang Zhaoliang
Published: April 2021

Vacuum-drying and freeze-drying were adopted to improve the catalytic activity of Ce0.5Pr0.5O2 for soot combustion. The specific surface area and pore volume of the as-prepared Ce0.5Pr0.5O2 were greatly increased compared to the counterpart using the common drying method. Furthermore, the redox performance and the oxidation ability for soot were enhanced, as demonstrated by H2-TPR and soot-TPR. Thus, lower combustion temperatures and higher intrinsic activity were obtained. This work demonstrated that simply changing the drying process of precipitates can be served as a paradigm to improve the structure and catalytic performance.
Identification of Growth-Associated Genes by Genome-Wide Association Study and Their Potential Application in the Breeding of Pacific White Shrimp (Litopenaeus vannamei)
Authors: Lyu Ding , Yu Yang , Wang Quanchao , Luo Zheng , Zhang Qian , Zhang Xiaojun , Xiang Jianhai , Li Fuhua
Published: April 2021

The Pacific white shrimp (Litopenaeus vannamei) is the most widely cultured shrimp in the world. A great attention has been paid to improve its body weight (BW) at harvest through genetic selection for decades. Genome-wide association study (GWAS) is a tool to dissect the genetic basis of the traits. In this study, a GWAS approach was conducted to find genes related to BW through genotyping 94,113 single nucleotide polymorphisms (SNPs) in 200 individuals from a breeding population. Four BW-related SNPs located in LG19 and LG39 were identified. Through further candidate gene association analysis, the SNPs in two candidate genes, deoxycytidylate deaminase and non-receptor protein tyrosine kinase, were found to be related with the body weight of the shrimp. Marker-assisted best linear unbiased prediction (MA-BLUP) based on the SNPs in these two genes was used to estimate the breeding values, and the result showed that the highest prediction accuracy of MA-BLUP was increased by 9.4% than traditional BLUP. These results will provide useful information for the marker-assisted breeding in L. vannamei.