bluuebunny/crossref_metadata_2025 huggingface dataset:
Study on a New Transient Productivity Model of Horizontal Well Coupled with Seepage and Wellbore Flow
Authors: Liu Peng , Wang Qinghua , Luo Yanli , He Zhiguo , Luo Wei
Published: December 2021

Digital transformation has become one of the major themes of the development of the global oil industry today. With the development of digital transformation, on-site production will surely achieve further automated management, that is, on-site production data automatic collection, real-time tracking, diagnosis and optimization, and remote control of on-site automatic adjustment devices. In this process, the realization of real-time optimization work based on massive data collection needs to be carried out combined with oil and gas well transient simulation. Therefore, research of the horizontal well capacity prediction transient model is one of the important basic works in the work of oil and gas digital transformation. In this paper, the method and process of establihing the transient calculation model of single-phase flow in horizontal wells are introduced in detail from three aspects: reservoir seepage, horizontal wellbore flow (taking one kind of flow as an example), and the coupling model of two flows. The model is more reliable through the verification of pressure recovery data from multiple field logs. The transient model of single-phase seepage in horizontal wells will lay the foundation for the establishment of transient models of oil-gas two-phase seepage and oil-gas-water three-phase seepage.
A Novel Model for Landslide Displacement Prediction Based on EDR Selection and Multi-Swarm Intelligence Optimization Algorithm
Authors: Zhang Junrong , Tang Huiming , Tannant Dwayne D. , Lin Chengyuan , Xia Ding , Wang Yankun , Wang Qianyun
Published: December 2021

With the widespread application of machine learning methods, the continuous improvement of forecast accuracy has become an important task, which is especially crucial for landslide displacement predictions. This study aimed to propose a novel prediction model to improve accuracy in landslide prediction, based on the combination of multiple new algorithms. The proposed new method includes three parts: data preparation, multi-swarm intelligence (MSI) optimization, and displacement prediction. In the data preparation, the complete ensemble empirical mode decomposition (CEEMD) is adopted to separate the trend and periodic displacements from the observed cumulative landslide displacement. The frequency component and residual component of reconstructed inducing factors that related to landslide movements are also extracted by the CEEMD and t-test, and then picked out with edit distance on real sequence (EDR) as input variables for the support vector regression (SVR) model. MSI optimization algorithms are used to optimize the SVR model in the MSI optimization; thus, six predictions models can be obtained that can be used in the displacement prediction part. Finally, the trend and periodic displacements are predicted by six optimized SVR models, respectively. The trend displacement and periodic displacement with the highest prediction accuracy are added and regarded as the final prediction result. The case study of the Shiliushubao landslide shows that the prediction results match the observed data well with an improvement in the aspect of average relative error, which indicates that the proposed model can predict landslide displacements with high precision, even when the displacements are characterized by stepped curves that under the influence of multiple time-varying factors.
AttendAffectNet–Emotion Prediction of Movie Viewers Using Multimodal Fusion with Self-Attention
Authors: Thao Ha Thi Phuong , Balamurali B T , Roig Gemma , Herremans Dorien
Published: December 2021

In this paper, we tackle the problem of predicting the affective responses of movie viewers, based on the content of the movies. Current studies on this topic focus on video representation learning and fusion techniques to combine the extracted features for predicting affect. Yet, these typically, while ignoring the correlation between multiple modality inputs, ignore the correlation between temporal inputs (i.e., sequential features). To explore these correlations, a neural network architecture—namely AttendAffectNet (AAN)—uses the self-attention mechanism for predicting the emotions of movie viewers from different input modalities. Particularly, visual, audio, and text features are considered for predicting emotions (and expressed in terms of valence and arousal). We analyze three variants of our proposed AAN: Feature AAN, Temporal AAN, and Mixed AAN. The Feature AAN applies the self-attention mechanism in an innovative way on the features extracted from the different modalities (including video, audio, and movie subtitles) of a whole movie to, thereby, capture the relationships between them. The Temporal AAN takes the time domain of the movies and the sequential dependency of affective responses into account. In the Temporal AAN, self-attention is applied on the concatenated (multimodal) feature vectors representing different subsequent movie segments. In the Mixed AAN, we combine the strong points of the Feature AAN and the Temporal AAN, by applying self-attention first on vectors of features obtained from different modalities in each movie segment and then on the feature representations of all subsequent (temporal) movie segments. We extensively trained and validated our proposed AAN on both the MediaEval 2016 dataset for the Emotional Impact of Movies Task and the extended COGNIMUSE dataset. Our experiments demonstrate that audio features play a more influential role than those extracted from video and movie subtitles when predicting the emotions of movie viewers on these datasets. The models that use all visual, audio, and text features simultaneously as their inputs performed better than those using features extracted from each modality separately. In addition, the Feature AAN outperformed other AAN variants on the above-mentioned datasets, highlighting the importance of taking different features as context to one another when fusing them. The Feature AAN also performed better than the baseline models when predicting the valence dimension.
Evaluation of Antibody Response to Heterologous Prime–Boost Vaccination with ChAdOx1 nCoV-19 and BNT162b2: An Observational Study
Authors: Firinu Davide , Perra Andrea , Campagna Marcello , Littera Roberto , Meloni Federico , Sedda Francesca , Conti Maria , Costanzo Giulia , Erbi Monica , Usai Gianmario , Locci Carlotta , Carta Mauro Giovanni , Cappai Riccardo , Orrù Germano , Del Giacco Stefano , Coghe Ferdinando , Chessa Luchino
Published: December 2021

In several countries, thrombotic events after vaccination with ChAdOx1 nCoV-19 have led to heterologous messenger RNA (mRNA) boosting. We tested the antibody response to SARS-CoV-2 spike protein four weeks after heterologous priming with the ChAdOx1 (ChAd) vector vaccine followed by boosting with BNT162b2(ChAd/BNT), comparing data of homologous regimen (BNT/BNT, ChAd/ChAd) subjects positive for SARS-CoV-2 after the first dose of BNT162b2 (BNT1dose/CoV2) and convalescent COVID-19. Methods: healthy subjects naïve for SARS-CoV-2 infection were assessed for serum IgG anti-S-RBD response 21 days after priming (T1), 4 (TFULL) and 15 (T15W) weeks after booster dose. Results: The median IgG anti-S-RBD levels at TFULL of Chad/BNT group were significantly higher than the BNT/BNT group and ChAd/ChAd. Those of BNT/BNT group were significantly higher than ChAd/ChAd. IgG anti-S-RBD of BNT1dose/CoV2 group were similar to BNT/BNT, ChAd/BNT and ChAd/Chad group. The levels among COVID-19 convalescents were significantly lower than ChAd/BNT, BNT/BNT, ChAd/Chad and BNT1dose/CoV2. The proportion of subjects reaching an anti-S-RBD titer >75 AU/mL, correlated with high neutralizing titer, was 94% in ChAd/BNT and BNT/BNT, 60% in BNT1dose/CoV2, 25% in ChAd/ChAd and 4.2% in convalescents. At T15W the titer of ChAd/BNT was still significantly higher than other vaccine schedules, while the anti-S-RBD decline was reduced for ChAd/ChAd and similar for other combinations. Conclusion: Our data highlight the magnitude of IgG anti-S-RBD response in ChAd/BNT dosing, supporting the current national guidelines for heterologous boosting
Adjuvant Activity of CpG-Oligonucleotide Administered Transcutaneously in Combination with Vaccination Using a Self-Dissolving Microneedle Patch in Mice
Authors: Hirobe Sachiko , Kawakita Takuto , Yamasaki Taki , Ito Sayami , Tachibana Masashi , Okada Naoki
Published: December 2021

In this study, we investigated the mechanism of transcutaneous adjuvant activity of the CpG-oligonucleotide (K3) in mice. Transcutaneous immunization (TCI) with an ovalbumin-loaded self-dissolving microneedle patch (OVA-sdMN) and K3-loaded hydrophilic gel patch (HG) increased OVA-specific Th2- and Th1-type IgG subclass antibody titers more rapidly and strongly than those after only OVA-sdMN administration. However, the antigen-specific proliferation of OVA-specific CD4+ T cells was similar between the OVA-only and the OVA+K3 groups. Population analysis of various immune cells in draining lymph nodes (dLNs) in the primary immune response revealed that the OVA+K3 combination doubled the number of dLN cells, with the most significant increase in B cells. Phenotypic analysis by flow cytometry revealed that B-cell activation and maturation were promoted in the OVA+K3 group, suggesting that direct B-cell activation by K3 largely contributed to the rapid increase in antigen-specific antibody titer in TCI. In the secondary immune response, a significant increase in effector T cells and effector memory T cells, and an increase in memory B cells were observed in the OVA+K3 group compared with that in the OVA-only group. Thus, K3, as a transcutaneous adjuvant, can promote the memory differentiation of T and B cells.
Genetic Diversity and Population Structure for Resistance and Susceptibility to Mastitis in Braunvieh Cattle
Authors: Trujano-Chavez Mitzilin Zuleica , Sánchez-Ramos Reyna , Pérez-Rodríguez Paulino , Ruíz-Flores Agustín
Published: December 2021

Mastitis is a disease that causes significant economic losses, since resistance to mastitis is a difficult trait to be improved due to its multifactorial occurrence. Therefore, our objective was to characterize a Mexican Braunvieh cattle population for genetic resistance and susceptibility to mastitis. We used 66 SNP markers for 45 candidate genes in 150 animals. The average heterozygosity was 0.445 ± 0.076, a value higher than those reported for some European breeds. The inbreeding coefficient was slightly negative for resistance to subclinical (−0.058 ± 0.055) and clinical (−0.034 ± 0.076) mastitis, possibly due to low selection for the immunological candidate genes that influence these traits. The genotypic profiles for the candidate loci per K-means group were obtained, as well as the group distribution through the graphics of the principal component analysis. The genotypic profiles showed high genetic diversity among groups. Resistance to clinical mastitis had the lowest presence of the heterozygous genotypes. Although the percentage of highly inbred animals (>50%) is up to 13.3%, there are highly heterozygous groups in terms of the studied traits, a favorable indicator of the presence of genetic diversity. The results of this study constitute evidence of the genetic potential of the Mexican Braunvieh population to improve mastitis-related traits.
Mathematical modeling of the epidemic of influenza and acute respiratory viral infections processes (ARVI) in the Yaroslavl region
Authors: Shirina Natalia Ur'evna , Druzhinina Tatiana Aleksandrovna , Shirina Elizaveta Sergeevna
Published: December 2021

In the structure of infectious diseases in the Yaroslavl region, more than 90 % are influenza and acute respiratory viral infections (ARVI). Influenza occupies a special place among human infectious diseases. This is due to its ability to epidemic and pandemic spread in a relatively short time. In this regard, scientific research on the analysis and forecasting of probable scenarios for the development of epidemic processes is of particular importance. The work used the data of the forms of the federal state statistical observation No. 2 “Information on infectious and parasitic diseases”. Fourier analysis was used to process time series. The significance of the mathematical model was checked using the Fisher test. The table of critical values of the Fisher criterion was used to assess the statistical significance, the significance level was taken equal to 0.05. Data processing was carried out using MS Excel 2013 software. During the study of the dynamics of the epidemic process, the trend of reducing the incidence of influenza and ARVI in the Yaroslavl region over the past 36 years has been determined. The dynamics of the incidence of influenza and ARVI in the Yaroslavl region over the past 36 years has a tendency to decrease. As a result of calculations, we obtained cyclical components with periods equal to 3 and 5 years. This is due to the accumulation of people who are not immune to these infections. Mathematical calculations have confirmed the values of seasonal fluctuations in 6 and 12 months. The maximum number of sick people is recorded in the winter-spring period (February — March). In accordance with the calculations, a decrease in the incidence of influenza and ARVI in the Yaroslavl region is expected in the period from 2020 to 2022: in 2020 the number of sick people (per 100 thousand population) is predicted to be 20 962.64, in 2021 — 18 138.58.
Use of the public-and-private partnership agreements in the conditions of imperfection of legal regulations in the Russian Federation
Authors: Polyakova I. S.
Published: December 2021

The objective of this research is to consider some controversial issues of the development of public-and-private partnership (and concession agreements as its most common form) in Russia. Some complaints made by Federal Antimonopoly Service of the Russian Federation to some infrastructure projects are reviewed. The author studied dynamics of private investments into infrastructure projects in the conditions of imperfect legal regulation. The assessment of the validity of the position of Federal Antimonopoly Service is given. It is predicted whether the legislative collisions will prevent the growth of private investments into infrastructure. Recommendations on the development of the mechanism of public-and-private partnership with the observance of antimonopoly regulation, as well as recommendation on the improvement of the legislation in this area are developed. The results of the research can be used by both private participants of public-and-private partnership and the federal, regional and municipal authorities, and also by legislators working on the improvement of the legislative regulation in this area.
Composición química y biotoxicidad del alga roja Kappaphycus alvarezii Doty (Solieriaceae)
Authors: Haydelba D’Armas , Marylin Neyra , Mary Isabel Segnini , Leonor Brito , Barrios Jorge
Published: December 2021

Se  realizó  un  estudio  fitoquímico  y  de  bioactividad  a  los  extractos  en cloroformo, acetato de etilo y metanol del alga Kappaphycus alvarezii Doty (recolectada en la Isla de Cubagua, Venezuela). Los valores de CL50 en el bioensayo realizado con todos  los  extractos  obtenidos,  mostraron  toxicidad  ante  larvas  del  crustáceo  Artemia salina  (CL50  <  300  μg.ml-1).  Mediante  cromatografías  en  columna  y  capa  fina preparativa, se  fraccionaron continuamente los extractos en cloroformo  y en acetato de etilo,  analizándose  algunas  subfracciones  obtenidas  mediante  CG-EM  e  identificándose algunos de sus constituyentes por sus patrones de fragmentación y comparación de sus espectros de masas con los existentes en la base de datos. Encontrándose que la fracción A2 proveniente del extracto en acetato de etilo presentó como componentes mayoritarios al ácido hexadecanoico, dibutilftalato y el compuesto esteroidal colestano; además de 2,6- diter-butilciclohexa-2,5-dieno-1,4-diona,  6,10,14-trimetil-2-pentadecanona,  ácido  2- fenilacético  y  1-(1-propoxi)  propano.  Mientras  que  la  fracción  FD  del  extracto  en cloroformo exhibió a los ácidos grasos saturados palmítico, esteárico y mirístico, como componentes abundantes; y en menor proporción a la 3-etil-4-metil-1H-pirrol-2,5-diona. En  la  fracción  EM7  proveniente  del  fraccionamiento  del  extracto  metanólico,  se  logró identificar al ácido octadecanoico a través de RMN uni y bidimensional. En la fracción FG del extracto en cloroformo, se caracterizó al 1-fenilbutan-1-ol, mediante esta misma técnica  espectroscópica. Los distintos metabolitos secundarios identificados constituyen el  primer  reporte  para  K.  alvarezii  y  posiblemente  sean  los  responsables  de  la bioactividad  in  vitro  observada.  Se  puede  inferir  que  esta  alga  roja  es  una  fuente promisoria de compuestos bioactivos.
Páginas preliminares del Vol. 2 No. 2
Authors: Editorial Equipo
Published: December 2021

Contenido, Listado de responsables de está edición.
Páginas preliminares del Vol. 2 No. 3
Authors: Editorial Equipo
Published: December 2021

Páginas preliminares del Vol. 2 No. 3

Responsables de está edición y normas generales de la revista
Editorial: Transmitiendo ciencia para el desarrollo de la acuicultura en Iberoamérica
Authors: Lodeiros César
Published: December 2021

Arribamos a este sexto número de AquaTechnica, ya con cierta holgura por recibir más manuscritos para su evaluación y publicación, producto de lo que entendemos como el comienzo del reconocimiento de nuestra revista, gracias a las evaluaciones recibidas por repositorios e índices de divulgación científica. Debido a ello, el Instituto de Posgrado de la Universidad Técnica de Manabí (Ecuador), ha seleccionado a AquaTechnica como revista indexada que cumple las condiciones para que su alumnado pueda publicar trabajos de investigación en función de cumplir con el prerrequisito de formación de cuarto nivel que, por ley, exige el postgrado a sus estudiantes para la titulación.
 
Con el presente número, AquaTechnica ha publicado ya 31 artículos científicos (22 artículos originales, 4 comunicaciones cortas, 3 ensayos y 2 revisiones) con una tasa de rechazo de un 25% de los manuscritos recibidos, tras la evaluación de al menos 2 especialistas pares, gestionando así un aporte al conocimiento científico y al desarrollo de la acuicultura que, esperamos, siga creciendo. Por otra parte, AquaTechnica también ha sido para muchos autores escuela para publicar, ya que nuestros revisores, editores y comité editorial, son conscientes de que tienen la tarea de evaluar no solo la validez e impacto del manuscrito, sino de mejorarlo para que el conocimiento aportado se exprese de la forma más adecuada posible por los canales de divulgación científica.
Actividad antagónica de bacterias aisladas de ecosistemas marinos frente a vibrio parahaemolyticusAHPND como patógeno de camarón en cultivos
Authors: Molina Garza Zinnia Judith , Cázares Jaramillo Gabriel Enrique , Ibarra Gámez José Cuauhtémoc , Galaviz Silva Lucio
Published: December 2021

Referente al sector acuícola, uno de los mayores sectores de producción de alimentos es el cultivo de camarón, sin embargo, se ha visto afectado por enfermedades, entre ellas la Enfermedad de la Necrosis Aguda del Hepatopáncreas (AHPND, por sus siglas en inglés) la cual es causada por Vibrio parahaemolyticus que hospeda un plásmido productor de tóxinas PirA y Pir B. Un método alternativo para controlar el agente causal es la aplicación de probióticos, los cuales, al ser consumidos por el camarón, le confieren un mecanismo de defensa frente a patógenos. En esta investigación se evaluaron bacterias de ecosistemas marinos y se aislaron con la prueba de difusión en pozo, al mostrar un efecto antagónico en contra de la cepa patógena de camarón, produciendo halos de inhibición desde uno a casi cuatro centímetros de diámetro; además, se caracterizaron estas bacterias por un perfil bioquímico con el sistema API BioMérieux y por secuenciación del gen 16S rADN identificándose en los géneros Shewanella sp., Vibrio sp. y Bacillus sp. Es de suma importancia la capacidad que presentan estas bacterias para ser potencialmente utilizadas como una medida profiláctica y/o terapéutica en granjas camaronícolas evitándose el uso de antibióticos.
Páginas preliminares del Vol. 3 No. 2
Authors: Editorial Equipo
Published: December 2021

Portada Vol. 3 No. 2 

Créditos, Normas 

Lista de contenido
Crecimiento y supervivencia de juveniles de chame Dormitator latifrons (Richardson 1844) alimentados con dietas a base de sacha inchi (Plukenetia volubilis L. 1753, Plantae: Euphorbiaceae)
Authors: Zambrano-Andrade Víctor Hugo , Panta-Vélez Rodolfo Patricio , Isea-León Fernando Ramón
Published: December 2021

Se realizó un trabajo experimental con juveniles de chame Dormitator latifrons con el objeto de evaluar la sustitución de harina de pescado en un alimento balanceado por harina de torta de sacha inchi (Plukenetia volubilis) y su efecto en el crecimiento y la supervivencia en cultivo intensivo. Un total de 360 organismos con peso promedio de 49,7 ± 4,42 g, fueron distribuidos al azar en doce tanques de geomembrana de 2 m de diámetro con 2000 L de agua/tanque, con una densidad de siembra de 15 chames/m3, durante 100 días. Se utilizaron cuatro dietas experimentales con 35% de proteína cruda: D1 (50% harina de sacha inchi-HSI y 50% harina de pescado-HP), D2 (75% HSI y 25% HP), D3 (100% HSI) y DC (100% HP), cada una con tres réplicas. Al final del estudio no hubo diferencias significativas tanto en las supervivencias (> 98,89%), como en incremento de peso de los peces entre los tratamientos dietéticos, pero con una elevada variabilidad de respuestas (6,9 - 14,2 g). Adicionalmente, las relaciones longitud total-peso total de las diferentes dietas no mostraron variaciones significativas, sugiriendo condiciones fisiológicas similares. Las tasas de crecimiento en el presente estudio son menores a las reportadas en investigaciones previas con piensos comerciales, dónde la densidad de siembra fue menor (hasta la mitad de la utilizada en el presente estudio).  Los resultados muestran que, el uso de harina de sacha inchi es equiparable al uso de harina de pescado, lo cual sugiere la factibilidad del uso de sacha inchi como sustituto de harina de pescado en dietas balanceadas, aun en altas proporciones.
Juveniles de jurel de Castilla, Seriola dorsalis alimentados con dietas con sustitución parcial a total del aceite y harina de pescado
Authors: Manriquez-Patiño Andrea , Paredes-Gutierrez Guillermo , Skrzynska Arleta Krystyna , Tinajero Aurora , Mata-Sotres José Antonio , Cavalheiro Araújo Bruno , Viana María Teresa
Published: December 2021

Este estudio tuvo como objetivo evaluar el efecto de la sustitución parcial a total de la harina de pescado (FM) y el aceite de pescado (FO) de las dietas formuladas para el jurel de Castilla (Seriola dorsalis), utilizando harina de subproductos avícolas (PBM) como la principal fuente de proteína, y sebo de res como principal fuente de grasa suplementado con aceite de microalgas de Schizochytrium sp. Se formularon cuatro dietas experimentales isoproteicas (45.0% de proteína cruda) e isolipídicas (12.0% de grasa cruda), con base en los requerimientos nutricionales del jurel de Castilla. Se añadió colesterol para compensar su contenido en el FO. También se agregaron lisina y metionina para compensar su falta en el PBM. Se incorporó adicionalmente la harina de microalgas para alcanzar niveles similares de DHA que los presentes en FM y FO. Los juveniles de S. dorsalis se distribuyeron aleatoriamente (180 con 14.54 g ± 0.19 g, media ± SE) en 12 tanques de 500 L cada uno. Los cuales estaban conectados a un sistema de recirculación. Después de 48 días de experimentación, no se observaron diferencias significativas en el rendimiento. Se concluye que el PBM puede reemplazar eficientemente a FM y FO en dietas para S. dorsalis sin ningún impacto negativo, donde la combinación de ácidos grasos contenida en el reemplazo total favoreció el uso de grasas como fuente de energía si se enriquece con DHA. Sin embargo, será interesante estudiar la expresión génica dentro del eje de crecimiento para comprender mejor el papel del crecimiento en peso en comparación al crecimiento en longitud.
3D Printing in Veterinary Medicine
Authors: YILGÖR HURİ Pınar , OTO Çağdaş
Published: December 2021

The use of 3D printing technology in the field of medicine, which started with the millennium, continues to increase today. Depending on the technological developments in this field, the use of rapid prototyping technology in the field of veterinary medicine is becoming widespread with the development of 3D printers, increasing material variety, cheaper printing costs and being more accessible. Additive manufacturing is used in veterinary education and training, experimental research and clinical studies, and its area of use is expanding day by day. In this review, both the current usage potential will be evaluated and the expected developments in the near future will be revealed.
Justification of the choice of indicators for assessing load hypoxia in humans and laboratory animals
Authors: Kim A.E. , Shustov E.B. , Lemeshchenko A.V.
Published: December 2021

In a study on healthy athletes of the track and field profile, it was shown that the hypoxia of physical activity is most fully reflected by the indicator of specific oxygen debt (maximum oxygen debt divided by 1000 J of work performed). When simulating load hypoxia in laboratory animals, direct registration of the arising oxygen debt is technically difficult to implement, and its indirect signs may be a decrease in peripheral blood saturation, excessive tachycardia, and hyperlactatemia of the post-load period.

Key words: hypoxia of physical activity, oxygen debt, athletes, laboratory animals, blood lactate, physical activity.
Development of an original method for the repair of paracolostomy hernias
Authors: Kiselev V.E.
Published: December 2021

The proposed surgical procedure was studied on six unfixed male human cadavers. The removal of the end colostomy and paracolostomy hernia with subsequent intra-abdominal implantation of a previously prepared hernioprosthesis from the xenopericardium were modeled on the corpses. The use of the proposed method for the repair of paracolostomy hernias, including the use of a xenopericardial plate as an endoprosthesis according to an original technique, has shown its consistency and prospects for use on clinical material. Further studies associated with the use of the proposed technique of paracolostomy hernia repair in clinical practice seem promising.

Key words: Colostomy, paracolostomy hernia, implantation, hernioprosthesis, xenopericardium.
Role of ACE gene polymorphism (RS4646994) in the pathogenesis of arterial hypertension formation in person performing task in the Arctic region
Authors: Lemeshchenko A.V. , Kim A.E.
Published: December 2021

The results of content analysis of the role of polymorphism of the ACE gene genotype (RS4646994) in persons employed in the Arctic region are presented. It has been shown that it can be recommended as a universal marker in the diagnosis of not only essential hypertension, but other diseases of the cardiovascular system. In order to reduce the risk of developing pathological conditions, when planning official activities in the Arctic region, it is advisable to build professional selection, taking into account not only their genetic predisposition, but also the body's ability to maintain homeostasis.

Key words: Arctic, polymorphism, ACE gene (RS4646994), arterial hypertension, homeostasis.
Morphofunctional features of proliferating cells exposed to PSMA peptide
Authors: Mikheeva N.A. , Drozhdina E.P. , Kurnosova N.A.
Published: December 2021

The effect of the synthetic PSMA peptide on dividing cells of laboratory animals was studied. The experiment was carried out on male white laboratory mice of the BALB/c-line. The toxic effect of PSMA peptidi was evaluated at therapeutic (1.4 μg / kg of animal weight or 0.04 μg / animal) and subtoxic (140 μg / kg of animal weight or 4.0 μg / animal) doses. The cytotoxic effect of PSMA peptide on red bone marrow cells and cambial intestinal cells of the of laboratory mice was determined. A decrease in the proliferative activity of the colon crypt cells was revealed upon administration of a subtoxic dose of the PSMA peptide and there were no signs of toxic damage to the red bone marrow cells of animals.

Key words: toxicity, proliferation, synthetic peptides, mitotic index, micronucleus test.
Preparation of copper pectate preparation for use in medical practice
Authors: Mikheeva L.A. , Shchelkaev S.A. , Mikheeva A.V.
Published: December 2021

Currently, the processes of complexation of various ligands, including biopolymers with metals, attract the attention of scientists from different countries not only in order to obtain new data on the methods of synthesis and properties of metal complexes, but also in connection with the search for ways to obtain new effective biologically active drugs among them.

Since the life around us is oversaturated with various artificially produced drugs that have a negative effect on the human body, today, more than ever before, the question arises of using natural, environmentally friendly ingredients instead of synthetic ones, for example, such as pectin. The study of the structural parameters and physico-chemical properties of complexes of pectin substances with metals will significantly expand the scope of their practical use.

Key words: metal complexes, pectin, copper pectate, complex formation.
Assessment of the adaptive state of students based on the analysis of heart rate variability indicators
Authors: Mishchenko N.V. , Lyalyakin S.V. , Shirkin L.A. , Knyazeva E.S. , Trifonova T.A.
Published: December 2021

In the course of the study, the adaptive state of VlSU students was assessed by temporal, spectral, cardiointervalographic and integral indicators of heart rate variability. The characteristic of the state of the regulatory systems of students is given. The obtained results can serve as a certain addition to the understanding of the peculiarities of the process of adaptation of young students in the conditions of studying at higher school.

Key words: heart rate variability (HRV), students, adaptation, regulatory systems, sympathetic and parasympathetic influence.
Ecomonitoring of water protected natural areas of the Ulyanovsk region on the example of the Yulovsky pond
Authors: Rassadina E.V. , Viderker M.A.
Published: December 2021

The Ulyanovsk region is rich in water natural monuments, and the Yulovsky pond is one of the oldest. At the same time, there is no generally accepted methodology for conducting environmental monitoring for protected water bodies. We propose one of the options for the methodology for assessing the anthropogenic load on protected water bodies in order to optimize the protection regime of these territories.

Key words: Yulovsky pond, ecological monitoring, specially protected natural area, chemical analysis of water, analysis of vegetation.
The pathomorphology of the renal cortex depending of arterial hypertension duration course
Authors: Slesareva E.V. , Ureneva R.V. , Slesarev S.M. , Lyapeykova O.V.
Published: December 2021

The kidneys autopsy material of persons with arterial hypertension in different duration was examined. Morphometry of the renal corpuscle area and cortical and juxtamedullary nephrons vascular glomeruli was performed. There were 4 groups - a control group (with a normal blood pressure level), and groups with arterial hypertension - the initial stage (group 2), arterial hypertension for 5-10 years (group 3), long-term arterial hypertension - more than 10 years (group 4). It was found that cortical nephrons are distinguished by earlier and more pronounced hyperplasia of the vascular glomerulus, they are more rapidly exposed to sclerosis, which appears in the 5-10th year of the course of the disease. The hyperplasia of the vascular glomerulus components is progressively increasing in juxtaglomerular nephrons, they are less susceptible to sclerosis processes. Key words: arterial hypertension, juxtaglomerular apparatus, juxtamedullary nephrons, vascular glomerulus.
Influence of water concentration on the content of protein and nucleic acids in organs of chick embryos of different ages
Authors: Turganbaeva A.S.
Published: December 2021

The study was carried out in 10-, 14-15-, 18-20-day-old embryos and 1-2-day-old chickens of the Hy-Line breed. In chickens during embryogenesis, the peculiarities of the relationship between the main indicator of the ontogenetic growth of organs and tissues - the content of intracellular water by previously measured values: with the concentration of protein and nucleic acids in the organs of chicken embryos of different ages - were assessed.

It was found that in the period of 10-19 days of embryogenesis, the growth of organs is accompanied by a significant decrease in water content to varying degrees: noticeably higher in the liver and in the cerebral hemispheres - up to 14 days; from the 19th day, these changes are less pronounced. The results of the studied indicator in the muscles indicate advanced embryonic development with a more pronounced decrease in the water content in the red oxidative muscles in comparison with white muscles, where the decrease in the indicator is less pronounced.

Key words: chicken embryos, protein, nucleic acid, water content, pectoralis alba and gastrocnemius muscle.
The effect of temperature on the activity of the trigeminal nerve in the rat meningeal sheath
Authors: Fedorina A.I. , Gafurov O.Sh.
Published: December 2021

Migraine is a debilitating neurological disorder that affects approximately 1 billion people worldwide. It is known that migraine is associated with the activity of the trigeminal nerve, therefore, many studies are aimed at studying changes in the activity of the meningeal nerve fibers. It is known that inflammatory processes accompanied by temperature rise are often accompanied by headaches. Therefore, we investigated the effect of temperature increase on trigeminal nerve activity. It turned out that temperature increase leads to a significant increase in the frequency of action potentials in the trigeminal nerve.

Key words: migraine, trigeminal nerve, cluster analysis, action potential.
Effect of combined action of arsenic and antimony compounds on renal function in the subchronic test
Authors: Shestakov N.A. , Aizman R.I. , Ogudov A.S. , Chuenko N.F.
Published: December 2021

The study was conducted on male Wistar rats. We used 4 mathematically related series of doses prepared by sequential dilution of water from a man-made lake according to the scheme: arsenic: 0.15 - 0.05 - 0.016 - 0.0055, antimony: 0.68 - 0.227 - 0.075 - 0.025 mg/l. The animals were examined before inoculation (background), on days 40 and 90 of the experiment, taking into account the processes of cumulation of chemical elements in the kidneys. New data on the nature of nephrotoxic effects of arsenic and antimony in the long-term combined intake into the body of laboratory animals have been obtained.

Key words: water from a man-made lake, arsenic and antimony compounds, Wistar rats, nephrotoxicity.
Analysis of the content of nitric oxide (II) metabolites rats of different ages
Authors: Belova Y.I. , Yakovleva O.V.
Published: December 2021

Nitrogen monoxide is a gas transmitter that is an important intermediary in many organ systems, especially in the central nervous system. Nitrogen monoxide is involved in the relaxation of smooth vascular muscles, activation of neurons and responsible for the cytotoxicity of macrophages. The study of change nitrogen oxide metabolite concentration helps to determine its effects on human and animal organs. The study was carried out on laboratory animals of different ages. We used a spectrophotometric method to determine the level of metabolites based on the reaction of nitrites to the Griss reagent. We noted that the maximum level of metabolites NO was observed in newborn animals at the age of 4 days. In addition, metabolite concentrations decreased gradually by 14-15 days of life, reaching a minimum of 30 days

Key words: nitrogen monoxide, rats, age, metabolites of nitrogen monoxide, spectrophotometry.
The relationship between the component composition of the body and the rate of aging of student youth
Authors: Bragina A.M.
Published: December 2021

Were examined 120 young men and young women. The analysis of the component composition was carried out using bioimpedance analysis by the MEDASS device. The coefficient of the aging rate was calculated according to the formula of A.G. Gorelkina. A correlation was established between the components of body composition and the rate of aging. The probability of accelerated aging of the body increases in the presence of excess fat mass. 25% of young men and 18.3% of young women belong to the risk group with an increased content of adipose tissue and a reduced content of skeletal muscles.

Key words: aging, biological age, body component composition, students.
The role of K-channels in the formation of a nociceptive signal in the rat trigeminal nerve
Authors: Buglinina A.D. , Verkhoturova T.M. , Gafurov O.Sh. , Koroleva K.S. , Sitdikova G.F.
Published: December 2021

The central problem of this work is to elucidate the mechanisms of pain in migraine and to establish the role of Kv channels in regulating the excitability of meningeal afferents of the trigeminal nerve that form a pain signal in migraine. The study was conducted on a preparation of an isolated rat skull. It was found that Kv-channel inhibitors 4-aminopyridine (100 microns and 1 mM) and tetraethylammonium (5mm) lead to an increase in the excitability of trigeminal nerve afferents, at the same time, this effect was partially removed by a nonsteroidal anti–inflammatory agent - naproxen, and was not sensitive to sumatriptan, a classic anti-migraine drug.

Key words: migraine, K-channels, trigeminal nerve, 4-aminopyridine, tetraethylammonium, naproxen, sumatriptan.
Prospects for digitalization of the environmental monitoring system
Authors: Viderker M.A. , Rassadina E.V.
Published: December 2021

Currently, digitalization affects various sectors of the economy. The state plays a significant role in regulating digitalization. Digital transformation opens up great prospects for the ecology and nature management industry. The main advanced technologies that will allow the industry to reach a qualitatively new level are big data, the Internet of Things and artificial intelligence. The introduction of digital technologies and platform solutions into an integrated environmental monitoring system will allow to quickly carry out integrated collection, processing and analysis of data, forecasting and management decisions on environmental protection issues, and ensure the openness of data and decisions made.

Key words: digital technologies, digitalization, digital economy, ecology, nature management, environmental monitoring.
Personalized approach in optimizing the treatment of acute pancreatitis
Authors: Vlasov A.P. , Trofimov V.A. , Al-Kubaysi S.S. , Myshkina N.A. , Muratova T.A. , Umnov L.N. , Khachaturov M.Yu .
Published: December 2021

In order to determine the effectiveness of the use of remaxol based on a personalized approach in patients with acute pancreatitis, based on the establishment of gene polymorphism of integrin beta-3 (T1565C, ITGB3), integrin alpha-2 (C807T, ITGA2), fibrinogen (G(-455)A, FGB) and plasminogen activator inhibitor (5G(-675)4G, SERPINE1), a study of 84 patients with acute pancreatitis of varying severity was conducted. As a result of the study, it was proved that in order to increase the effectiveness of treatment of patients with severe acute pancreatitis upon admission, in addition to clinical, laboratory and instrumental studies, it is necessary to conduct genetic testing of the genotypes of the polymorphism of the GPIIa gene (T1565C), ITGA2 (C807T), FGB (G(-455)A) and SERPINE1 (5G(-675)4G) to develop a personalized approach in the treatment of this severe category of patients.

Key words: acute pancreatitis, genotype, DNA diagnostics, genetic testing of genotypes, personalized medicine.
The effect of mixed rot from the present tinder (Fomes fomentarius (L.:Fr.) Gill.) on the accumulation of heavy metals in the hanging birch (Betula pendula Roth.)
Authors: Gnusarev S.S. , Mitrofanova N.A. , Churakov B.P.
Published: December 2021

A study was conducted on the effect of mixed rot from the present tinder on the accumulation of heavy metals (copper, zinc, nickel, cadmium, lead, cobalt, iron) by hanging birch

Keywords: real tinder, mixed rot, heavy metals, hanging birch.
Morphofunctional assessment of platelet activity correction in hyperbaric blood oxygenation
Authors: Goriachaia M.N. , Altynbaeva E.N. , Ruzov V.I. , Slobodnyuk Н.А.
Published: December 2021

100 patients with functional class II-III exertional angina were examined. The subjects underwent a 10-day course of hyperbaric oxygenation (HBO) in the 1.2 ATA mode for 40 minutes, against the background of standard therapy for coronary heart disease (IHD). Before and after HBO, the platelet link of hemostasis and the elastic properties of the platelet membrane were assessed. Assessment of the effect of the HBO course on the functional state of platelets, depending on their aggregation activity, showed that in patients with initially normal platelet aggregation, there is a tendency to a decrease in spontaneous aggregation, in contrast to patients with initial hypoaggregation, HBO promoted a significant increase in spontaneous aggregation. The use of a 10-day course of HBO was accompanied by a reaction of reducing the elasticity of the platelet biomembrane.

Key words: aggregation; atomic force microscopy; platelet membrane; hyperbaric oxygenation.
Sexual dimorphism in the physical development of boys and girls of the northern region with an established dysplastic phenotype
Authors: Ilyushenko N.A. , Gainutdinova Yu.O. , Eskindyrova Z.B. , Ragozina O.V. , Shevnin I.A. , Jafarova B.Z.
Published: December 2021

The article analyzes the data of an anthropometric and somatotypological study of 164 boys and 93 girls of the northern region, different sexual somatotypes with different severity of signs-phenes of undifferentiated connective tissue dysplasia. It was found that 44% of boys and 22% of girls with d, according to sexual somatic differentiation, correspond to the biological sex, 34% of boys and 53% of girls have mild gender dysplasia in the form of mesomorphy, and 19% of boys and 21% of girls have signs of sex inversion. Undifferentiated connective tissue dysplasia affects the severity of morphotypological differences between sexual somatotypes and the appearance of signs of gracialization within them.

Key words: northern region, adolescence, sexual dimorphism, undifferentiated connective tissue dysplasia.
Spirituality among Health Professionals: An Exploratory Factor Analysis and a Moral Reflection
Authors: Alves Cristiane Paiva , Teztlaff de Gerone Lucas Guilherme , Macuchen Nogas Paulo Sergio
Published: December 2021

Even nowadays, there are few studies about the use of quantitative methods about the practice of caring among healthcare professionals.
Objectives: T o present a statistical analysis about spirituality, religiosity and health on the practice of caring between healthcare professionals. With the results found on the statistical analysis called exploratory factorial, there is a new reflection about spirituality and moral on the practice of caring that shows up, such as spirituality/religiosity on the life of healthcare professionals. The approach of spirituality/religiosity in the care of the sick person and in the training of healthcare professionals; the positive impact of spirituality/ religiosity on the treatment of the sick person and spirituality/religiosity on the practice of caring between pastoralist/ chaplains.
Methods: Quantitative survey-type research, classified and described as descriptive, applied to 89 (eighty nine) health professionals.
Fluid Gauge Theory
Authors: Kambe Tsutomu
Published: December 2021

According to the general gauge principle, Fluid Gauge Theory is presented to cover a wider class of flow fields of a perfect fluid without internal energy dissipation under anisotropic stress field. Thus, the theory of fluid mechanics is extended to cover time dependent rotational flows under anisotropic stress field of a compressible perfect fluid, including turbulent flows. Eulerian fluid mechanics is characterized with isotropic pressure stress fields. The study is motivated from three observations. First one is experimental observations reporting large-scale structures coexisting with turbulent flow fields. This encourages a study of how such structures observed experimentally are possible in turbulent shear flows, Second one is a theoretical and mathematical observation: the ”General solution to Euler’s equation of motion” (found by Kambe in 2013) predicts a new set of four background-fields, existing in the linked 4d-spacetime. Third one is a physical query, ”what symmetry implies the current conservation law ?”. The latter two observations encourage a gauge-theoretic formulation by defining a differential one-form representing the interaction between the fluid-current field jμand a background field aμ.
COMPUTER TECHNOLOGIES FOR DETERMINING INDEX ASSESSMENT OF THE DESTRUCTION OF DENTAL HARD TISSUES
Authors: Yanishen I.V. , German S.A. , Al-Saedi Z.A.
Published: December 2021

The aim of the study was to compare the obtained data of hard dental tissues destruction indices with the corresponding indications for the choice of the method of treatment by means of mathematical analysis.

Materials & methods. 120 patients aged 20 to 55 were examined and 358 teeth hard tissue defects were identified in them. The data of indices was obtained and compared with the indications for orthopedic treatment according two indices in the same clinical situation.

Results. The study showed that the indices had different meanings and different indications for treatment in the same situations. Such discrepancies in indications for treatment indicate the subjective data of one of the indices, which does not take into account the depth of destruction and the volume of the remaining natural tissue of the teeth. Comparison of these indices showed different figures in the same clinical situation, identifying corresponding incorrect indications for the choice of the design of the first investigated index, as well as more accurate data of the proposed index.

Conclusion. The index assessment of hard dental tissues destruction serves as the main guideline for the dentist when choosing a method for tooth restoration, and can be calculated using photographs, scans and computer software.
Sustainable and low-cost automated greenhouse prototype with a social focus for integral formation
Authors: ÁLVAREZ-TORRES Norma Angélica , VELARDE-ANAYA Omar , RODRÍGUEZ-ARENAS Mario Balvanedo , TORRES-ÁLVAREZ Sara
Published: December 2021

A low-cost automated greenhouse prototype was developed, which can be installed on rooftops, gardens, and even commercial greenhouses. This work was carried out through the use of an electronic control system, and a user interface, which allows it to be used by children, young people or adults of the Private Assistance Institution (IAP) "Manitas que hablan", contributing to the cultivation of flowers, herbs, fruits and vegetables. Surveys, experimental and observation was applied wish methodology of during the development of this project, to know the needs of the agricultural sector and to integrate the components of the systems for the automated greenhouse. The study demonstrates the feasibility of collaborative work in the development of a prototype that allows the germination of seeds and harvest of crops, and the importance of providing support to the social sector, promoting urban gardens for the integration of children and young people in this activity, achieving better health and food safety for the future.