bluuebunny/crossref_metadata_2025 huggingface dataset:
Brief Report: Dialister as a Microbial Marker of Disease Activity in Spondyloarthritis
Authors: Tito Raul Y. , Cypers Heleen , Joossens Marie , Varkas Gaëlle , Van Praet Liesbet , Glorieus Elien , Van den Bosch Filip , De Vos Martine , Raes Jeroen , Elewaut Dirk
Published: July 2016

Objective

Dysbiosis of the intestinal microbiota has been widely established in inflammatory bowel disease (IBD). There is significant clinical and genetic overlap between spondyloarthritis (SpA) and IBD, and up to 50% of all patients with SpA exhibit microscopic signs of bowel inflammation, often bearing particular resemblance to early Crohn's disease, a subtype of IBD. This study was undertaken to assess the relationship between intestinal microbial composition, gut histology, and disease activity markers in SpA.

Methods

Gene analysis by 16S ribosomal RNA amplicon sequencing was used to compare the microbial composition in ileal and colonic biopsy specimens from 27 patients with SpA (14 with microscopic bowel inflammation, 13 without) and 15 healthy control subjects (ileal samples from all 15 subjects and colonic samples from 6). Spearman's rank correlation tests were used to assess correlations of the microbial composition with disease activity measures.

Results

The intestinal inflammation status (histologically normal versus acute or chronic inflammation) was strongly associated with the mucosal microbiota profile of patients with SpA. In inflamed biopsy tissue, the detected bacterial community composition clustered separately from that in noninflamed biopsy tissue (P < 0.05 by permutational multivariate analysis of variance, using hierarchical clustering on Bray–Curtis distances). Interestingly, abundance of the genus Dialister was found to be positively correlated with the Ankylosing Spondylitis Disease Activity Score (Spearman's rho = 0.62, false discovery rate–corrected q < 0.01). This finding was further supported by the low frequency of Dialister observed in noninflamed ileal and colonic biopsy tissue from patients with SpA and healthy controls.

Conclusion

These findings demonstrate a significant difference in the intestinal microbial composition in patients with SpA who have microscopic gut inflammation compared to those without microscopic gut inflammation. Moreover, Dialister may represent a potential microbial marker of disease activity in SpA.
Post Hoc Analysis of the Phase II/III APRIL‐SLE Study: Association Between Response to Atacicept and Serum Biomarkers Including BLyS and APRIL
Authors: Gordon Caroline , Wofsy David , Wax Stephen , Li Yong , Pena Rossi Claudia , Isenberg David
Published: July 2016

Objective

To assess the relationship between treatment response, baseline biomarker levels, and atacicept exposure in patients with systemic lupus erythematosus (SLE) in the phase II/III APRIL‐SLE study.

Methods

We performed a post hoc analysis of patients who received placebo, atacicept 75 mg, or atacicept 150 mg in a randomized, controlled, 52‐week trial. Serum levels of BlyS and APRIL were measured at baseline, and serum levels of Ig and the numbers of naive B cells and plasma cells were measured at baseline and during treatment. Atacicept exposure was determined by assessment of the serum trough concentrations throughout the 52‐week trial period. Associations between these parameters, treatment response (reduction in British Isles Lupus Assessment Group A or B flare), and infection rates were explored.

Results

Recurrent high baseline levels of both BLyS (≥1.6 ng/ml) and APRIL (≥2.2 ng/ml) correlated with a greater treatment response (flare rate 75.7% with placebo, and 50.0% and 32.0% with atacicept 75 mg and atacicept 150 mg, respectively) compared with lower baseline levels of both. Increased atacicept exposure correlated with reduced flare rates (60.5% with placebo; 63.4%, 61.0%, 48.8%, and 29.3% in the 4 quartiles, from lowest to highest atacicept exposure). Greater pharmacodynamic responses (reduced Ig levels and naive B cell and plasma cell numbers) were associated with greater reductions in the flare rate. Infection rates were similar regardless of biomarker levels at baseline or at the time of atacicept exposure.

Conclusion

These post hoc analyses demonstrate a dose‐response relationship between atacicept concentrations, reduced Ig levels, and reduced flare rates and suggest that baseline biomarkers such as elevated serum levels of BLyS and APRIL may help to identify the patients who are most likely to benefit from atacicept treatment.
A Multifunctional Biomaterial with NIR Long Persistent Phosphorescence, Photothermal Response and Magnetism
Authors: Wu Yiling , Li Yang , Qin Xixi , Qiu Jianrong
Published: July 2016

There are many reports on long persistent phosphors (LPPs) applied in bioimaging. However, there are few reports on LPPs applied in photothermal therapy (PTT), and an integrated system with multiple functions of diagnosis and therapy. In this work, we fabricate effective multifunctional phosphors Zn3Ga2SnO8: Cr3+, Nd3+, Gd3+ with NIR persistent phosphorescence, photothermal response and magnetism. Such featured materials can act as NIR optical biolabels and magnetic resonance imaging (MRI) contrast agents for tracking the early cancer cells, but also as photothermal therapeutic agent for killing the cancer cells. This new multifunctional biomaterial is expected to open a new possibility of setting up an advanced imaging‐guided therapy system featuring a high resolution for bioimaging and low side effects for the photothermal ablation of tumors.
Maternal gene–micronutrient interactions related to one‐carbon metabolism and the risk of myelomeningocele among offspring
Authors: Nguyen Margaret P. , Lupo Philip J. , Northrup Hope , Morrison Alanna C. , Cirino Paul T. , Au Kit Sing
Published: July 2016

Background

Few studies have evaluated interactions between maternal genetic variation in 5,10‐methylenetetrahydrofolate reductase (MTHFR) and micronutrient intake on the risk of myelomeningocele (MM) in offspring. Therefore, we sought to determine if the role of maternal MTHFR C677T and A1298C on MM risk is altered by maternal intake of micronutrients related to one‐carbon metabolism.

Methods

The study consisted of 220 MM case–parent trios recruited from 1996 to 2006. A dietary questionnaire was used to obtain information on maternal dietary intake on eight micronutrients including folate and cobalamin. TaqMan assays were used to generate MTHFR C677T and A1298C genotypes. Log‐linear models were used to evaluate the joint effects of maternal genotype and micronutrient intake dichotomized as at or above versus below the United States Recommended Dietary Allowance (US RDA) on MM.

Results

There was little evidence to suggest maternal MTHFR genotypes interacted with micronutrient intake to influence the risk of MM. For instance, the effect of MTHFR 677T was similar for mothers with cobalamin intake below US RDA (relative risk [RR] = 0.97) versus at or above US RDA cobalamin intake (RR = 0.81, interaction p = 0.87). However, some differences were noted. For example, the effect of MTHFR 1298C appeared to be different between those mothers below US RDA folate intake (RR = 0.98) versus those at or above US RDA folate intake (RR = 0.68), but the interaction was not statistically significant (interaction p = 0.27).

Conclusion

There did not appear to be strong effects of maternal micronutrient intake on the role of maternal genetic polymorphisms in MTHFR C677T and A1298C on MM risk. Birth Defects Research 109:99–105, 2017. © 2016 Wiley Periodicals, Inc.
Experimental and molecular docking investigation on DNA interaction of N‐substituted phthalimides: antibacterial, antioxidant and hemolytic activities
Authors: Nayab Pattan Sirajuddin , Irfan Mohammad , Abid Mohammad , Pulaganti Madhusudana , Nagaraju Chinthakunta , Chitta Suresh Kumar , Rahisuddin
Published: July 2016

A series of Schiff base molecules derived from a phthalimide scaffold was investigated as efficient antibacterial, antioxidant and DNA‐interacting agents. The spectroscopic characterization of these derivatives was studied in detail using elemental analysis and spectroscopic techniques. The DNA‐binding profile of title molecules against Ct‐DNA (calf thymus) was investigated by absorbance, fluorescence, hydrodynamics and thermal denaturation investigations. The bacterial inhibition potential of these molecules was investigated against Escherichia coli and Staphylococcus aureus. Molecule 3c emerged as the most active against S. aureus (IC50: 14.8 μg/mL), whereas compounds 3a and 3b displayed potential antibacterial activities against E. coli (IC50: 49.7 and 67.6 μg/mL). Molecular docking studies of these compounds against GlcN‐6‐P synthase were carried out to rationalize antibacterial efficiency of these molecules. These newly synthesized molecules were screened for their scavenging capacity against 2,2‐diphenyl‐1‐picryl‐hydrazyl (DPPH) and H2O2 free radicals and the results were compared with ascorbic acid as synthetic antioxidant. The title molecules 3a, 3b and 3e showed less than 20% hemolysis, which indicated their significant non‐toxic behavior.
Biofunctionalizing nanofibers with carbohydrate blood group antigens
Authors: Barr Katie , Kannan Bhuvaneswari , Korchagina Elena , Popova Inna , Ryzhov Ivan , Henry Stephen , Bovin Nicolai
Published: July 2016

A rapid and simple method of biofunctionalising nylon, cellulose acetate, and polyvinyl butyral electrospun nanofibers with blood group glycans was achieved by preparing function‐spacer‐lipid constructs and simply contacting them to fibers with a piezo inkjet printer. A series of water dispersible amphipathic glycan‐spacer constructs were synthesized representing a range ABO and related blood group antigens. After immediate contact of the amphipathic glycan‐spacer constructs with nanofiber surfaces they self‐assembled and were detectable by enzyme immunoassays with high sensitivity and specificity.
Leukocyte telomere length in relation to the risk of Barrett's esophagus and esophageal adenocarcinoma
Authors: Wennerström E. Christina M. , Risques Rosa A. , Prunkard Donna , Giffen Carol , Corley Douglas A. , Murray Liam J. , Whiteman David C. , Wu Anna H. , Bernstein Leslie , Ye Weimin , Chow Wong‐Ho , Vaughan Thomas L. , Liao Linda M.
Published: July 2016

Chronic inflammation and oxidative damage caused by obesity, cigarette smoking, and chronic gastroesophageal reflux disease (GERD) are major risk factors associated with Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC). EAC has been increasing the past few decades, and early discovery and treatment are crucial for survival. Telomere shortening due to cell division and oxidative damage may reflect the impact of chronic inflammation and could possibly be used as predictor for disease development. We examined the prevalence of shorter leukocyte telomere length (LTL) among individuals with GERD, BE, or EAC using a pooled analysis of studies from the Barrett's and Esophageal Adenocarcinoma Consortium (BEACON). Telomere length was measured in leukocyte DNA samples by Q‐PCR. Participants included 1173 patients (386 with GERD, 384 with EAC, 403 with BE) and 736 population‐based controls. The association of LTL (in tertiles) along the continuum of disease progression from GERD to BE to EAC was calculated using study‐specific odds ratios (ORs) and 95% confidence intervals (CIs) from logistic regression models adjusted for potential confounders. Shorter LTL were less prevalent among GERD patients (OR 0.57; 95% CI: 0.35–0.93), compared to population‐based controls. No statistically significant increased prevalence of short/long LTL among individuals with BE or EAC was observed. In contrast to some earlier reports, our findings add to the evidence that leukocyte telomere length is not a biomarker of risk related to the etiology of EAC. The findings do not suggest a relationship between LTL and BE or EAC.
Reverse Transcription of Threose Nucleic Acid by a Naturally Occurring DNA Polymerase
Authors: Dunn Matthew R. , Chaput John C.
Published: July 2016

Recent advances in polymerase engineering have enabled the replication of xenonucleic acid (XNA) polymers with backbone structures distinct from those found in nature. By introducing a selective amplification step into the replication cycle, functional XNA molecules have been isolated by in vitro selection with binding and catalytic activity. Despite these successes, coding and decoding genetic information in XNA polymers remains limited by the fidelity and catalytic efficiency of engineered XNA polymerases. In particular, the process of reverse transcribing XNA back into DNA for amplification by PCR has been problematic. Here, we show that Geobacillus stearothermophilus (Bst) DNA polymerase I functions as an efficient and faithful threose nucleic acid (TNA)‐dependent DNA polymerase. Bst DNA polymerase generates ∼twofold more cDNA with threefold fewer mutations than Superscript II (SSII), which was previously the best TNA reverse transcriptase. Notably, Bst also functions under standard magnesium‐dependent conditions, whereas SSII requires manganese ions to relax the enzyme's substrate specificity. We further demonstrate that Bst DNA polymerase can support the in vitro selection of TNA aptamers by evolving a TNA aptamer to human α‐thrombin.
Imidazolyl‐Functionalized Ordered Mesoporous Polymer from Nanocasting as an Effective Support for Highly Dispersed Palladium Nanoparticles in the Heck Reaction
Authors: Karimi Babak , Marefat Mohammad Reza , Hasannia Maliheh , Akhavan Pari Fadavi , Mansouri Fariborz , Artelli Zahra , Mohammadi Fariba , Vali Hojatollah
Published: July 2016

New imidazolyl‐functionalized ordered mesoporous cross‐linked polymers were prepared by the copolymerization of the ionic liquid 3‐benzyl‐1‐vinyl‐1H‐imidazolium bromide with divinylbenzene as the cross‐linker and azobisisobutyronitrile as the radical initiator in the presence of O‐silylated SBA‐15 as the hard template. The materials were characterized by N2 adsorption–desorption analysis, TEM, thermogravimetric analysis, elemental analysis, and FTIR spectroscopy. The material, which benefits from the use of entrapped ionic liquid in the prepared polymer matrix in combination with its ordered mesoporous structure, is an excellent environment for the stabilization of highly dispersed Pd nanoparticles to result in a recyclable catalyst system with a significant activity in the Heck coupling reaction of aryl halides. The presence of well‐distributed imidazolium functionalities in the polymeric framework might be responsible for the relatively uniform and nearly atomic scale distribution of Pd nanoparticles throughout the mesoporous structure and the prevention of Pd agglomeration during the reaction, which results in high durability, high stability, and good recycling characteristics of the catalyst. Although our catalyst system operates in a homogeneous pathway, it is also very stable and recyclable.
The Role of Ate Complexes in the Copper‐Mediated Trifluoromethylation of Alkynes
Authors: Weske Sebastian , Schoop Ramona , Koszinowski Konrad
Published: July 2016

Trifluoromethylation reactions have recently received increased attention because of the beneficial effect of the trifluoromethyl group on the pharmacological properties of numerous substances. A common method to introduce the trifluoromethyl group employs the Ruppert–Prakash reagent, that is, Si(CH3)3CF3, together with a copper(I) halide. We have applied this method to the trifluoromethylation of aromatic alkynes and used electrospray‐ionization mass spectrometry to investigate the mechanism of these reactions in tetrahydrofuran, dichloromethane, and acetonitrile as well as with and without added 1,10‐phenanthroline. In the absence of the alkyne component, the homoleptic ate complexes [Cu(CF3)2]− and [Cu(CF3)4]− were observed. In the presence of the alkynes RH, the heteroleptic complexes [Cu(CF3)3R]− were detected as well. Upon gas‐phase fragmentation, these key intermediates released the cross‐coupling products R−CF3 with perfect selectivity. Apparently, the [Cu(CF3)3R]− complexes did not originate from homoleptic cuprate anions, but from unobservable neutral precursors. The present results moreover point to the involvement of oxygen as the oxidizing agent.
Windmill Co4{Co4(μ4‐O)} with 16 Divergent Branches Forming a Family of Metal–Organic Frameworks: Organic Metrics Control Topology, Gas Sorption, and Magnetism
Authors: Chen Qing , Xue Wei , Lin Jian‐Bin , Wei Yong‐Sheng , Yin Zheng , Zeng Ming‐Hua , Kurmoo Mohamedally , Chen Xiao‐Ming
Published: July 2016

A series of highly connected metal–organic frameworks (MOFs), [Co8(O)(OH)4(H2O)4(ina)8](NO3)2⋅2 C2H5OH⋅4 H2O (1), [Co8(O)(OH)4(H2O)4(pba)8](NO3)2⋅8 C2H5OH⋅28 H2O (2), and [Co8(O)(OH)4(H2O)4(pbba)8](NO3)2⋅guest (3), in which ina=isonicotinate, pba=4‐pyridylbenzoate, and pbba=4‐(pyridine‐4‐yl)phenylbenzoate, is reported. These MOFs contain a new secondary building unit (SBU), with a square Co4(μ4‐O) central unit having the rare μ4‐O2− motif, which is decorated by the other four peripheral cobalt atoms through μ3‐OH in a windmill‐like shape. This SBU holds 16 divergent connecting organic ligands, pyridyl‐carboxylates, to form three different frameworks. The high porosity of desolvated 2 is shown by the efficient gas absorption of N2, CO2, CH4, and H2. In addition, 1 and 2 exhibit unusual canted antiferromagnetic behavior with spin‐glass‐like relaxation, with blocking temperatures that are fairly high, 20 K (1) and 10 K (2), for cobalt materials. The relationship between the metal clusters and linkers has been studied, in which the size and rotational degrees of freedom of the ligands are found to control the topology, gas sorption, and magnetic properties.
Metal‐Catalyzed Cyclization Reactions of 2,3,4‐Trien‐1‐ols: A Joint Experimental–Computational Study
Authors: Alcaide Benito , Almendros Pedro , Cembellín Sara , Fernández Israel , Martínez del Campo Teresa
Published: July 2016

Controlled preparation of tri‐ and tetrasubstituted furans, as well as carbazoles has been achieved through chemo‐ and regioselective metal‐catalyzed cyclization reactions of cumulenic alcohols. The gold‐ and palladium‐catalyzed cycloisomerization reactions of cumulenols, including indole‐tethered 2,3,4‐trien‐1‐ols, to trisubstituted furans was effective, due to a 5‐endo‐dig oxycyclization by attack of the hydroxy group onto the central cumulene double bond. In contrast, palladium‐catalyzed heterocyclization/coupling reactions with 3‐bromoprop‐1‐enes furnished tetrasubstituted furans. Also studied was the palladium‐catalyzed cyclization/coupling sequence involving protected indole‐tethered 2,3,4‐trien‐1‐ols and 3‐bromoprop‐1‐enes that exclusively generated trisubstituted carbazole derivatives. These results could be explained through a selective 6‐endo‐dig cumulenic hydroarylation, followed by aromatization. DFT calculations were carried out to understand this difference in reactivity.
Light Harvesting and White‐Light Generation in a Composite of Carbon Dots and Dye‐Encapsulated BSA‐Protein‐Capped Gold Nanoclusters
Authors: Barman Monoj Kumar , Paramanik Bipattaran , Bain Dipankar , Patra Amitava
Published: July 2016

Several strategies have been adopted to design an artificial light‐harvesting system in which light energy is captured by peripheral chromophores and it is subsequently transferred to the core via energy transfer. A composite of carbon dots and dye‐encapsulated BSA‐protein‐capped gold nanoclusters (AuNCs) has been developed for efficient light harvesting and white light generation. Carbon dots (C‐dots) act as donor and AuNCs capped with BSA protein act as acceptor. Analysis reveals that energy transfer increases from 63 % to 83 % in presence of coumarin dye (C153), which enhances the cascade energy transfer from carbon dots to AuNCs. Bright white light emission with a quantum yield of 19 % under the 375 nm excitation wavelength is achieved by changing the ratio of components. Interesting findings reveal that the efficient energy transfer in carbon‐dot–metal‐cluster nanocomposites may open up new possibilities in designing artificial light harvesting systems for future applications.
ChemInform Abstract: Electronic, Crystal Chemistry, and Nonlinear Optical Property Relationships in the Dugganite A3B3CD2O14 Family.
Authors: Yu Hongwei , Young Joshua , Wu Hongping , Zhang Weiguo , Rondinelli James M. , Halasyamani P. Shiv
Published: July 2016

The nonlinear optical (NLO) materials Sr3Zn3TeP2O14, Ba3Zn3TeP2O14, Pb3Mg3TeP2O14, Pb3Zn3TeP2O14, Pb3Zn3WP2O14, and Pb3Zn3VP2O14 are prepared by solid state reactions of stoichiometric mixtures of alkaline earth carbonates, metal oxides, H2TeO4, and NH4H2PO4 (Pt crucible, 1.
ChemInform Abstract: Stabilization of HfB12 in Y1‐xHfxB12 under Ambient Pressure.
Authors: Akopov Georgiy , Yeung Michael T. , Turner Christopher L. , Li Rebecca L. , Kaner Richard B.
Published: July 2016

The high‐pressure HfB12 phase is stabilized in the Y1‐xHfxB12 (x = 0.00, 0.05, 0.25, 0.50, 0.75, 0.95) system (obtained by arc‐melting of the elements) under ambient pressure.
ChemInform Abstract: Tuning Complexity by Lithiation: A Family of Intergrowth Structures Using Condensed hypho‐Icosahedra in the Li‐Doped Ca—Zn System.
Authors: Lin Qisheng , Zhu Ran , Miller Gordon J.
Published: July 2016

The new intermetallic structures Ca12LixZn59‐x (x = 5.65—14.95) and Ca15Li19.07Zn55.93 are found to exist in the Ca—Li—Zn system.
ChemInform Abstract: Mixed‐Valent NaCu4Se3: A Two‐Dimensional Metal.
Authors: Sturza Mihai , Bugaris Daniel E. , Malliakas Christos D. , Han Fei , Chung Duck Young , Kanatzidis Mercouri G.
Published: July 2016

The new title compound is synthesized in quantitative yield by solid state reaction of a stoichiometric mixture of CuSe, Cu2Se, and Na (alumina crucible, 800 °C, 24 h, followed by annealing at 600 °C for 3 d).
ChemInform Abstract: One Pot Synthesis of Substituted Imidazopyridines and Thiazoles from Styrenes in Water Assisted by NBS.
Authors: Shinde Mahesh H. , Kshirsagar Umesh A.
Published: July 2016

A facile one pot procedure for the synthesis of substituted imidazopyridines and highly substituted thiazoles starting from styrenes is reported.
ChemInform Abstract: Oxidative Cleavage of C2—C3 Bond in Isatin Using (Diacetoxyiodo)benzene: A Facile Synthesis of Carbamates of Alkyl Anthranilates.
Authors: Kalbandhe Amit H. , Kavale Ashish C. , Thorat Prerana B. , Karade Nandkishor N.
Published: July 2016

In addition to the title transformation, the mild, metal‐free protocol is applied to the transformation of N‐acetyl isatins into 2‐acetamidobenzoates.
ChemInform Abstract: Enantioselective Hydrogenation of β,β‐Disubstituted Unsaturated Carboxylic Acids under Base‐Free Conditions.
Authors: Yan Qiaozhi , Kong Duanyang , Zhao Wei , Zi Guofu , Hou Guohua
Published: July 2016

The additive‐free protocol works also for β,β‐disubstituted unsaturated aldehydes and γ,γ‐disubstituted alcohols.
ChemInform Abstract: Regioselective Bromination of 1,4‐Dimethoxy‐2,3‐dimethylbenzene and Conversion into Sulfur‐Functionalized Benzoquinones.
Authors: Aitken R. Alan , Jethwa Siddharth J. , Richardson Neville V. , Slawin Alexandra M.Z.
Published: July 2016

Four different bromination products can be prepared from the starting material (I) including the novel compound (VIII).
ChemInform Abstract: Selective Heterogeneous C—H Activation/Halogenation Reactions Catalyzed by Pd@MOF Nanocomposites.
Authors: Pascanu Vlad , Carson Fabian , Solano Marta Vico , Su Jie , Zou Xiaodong , Johansson Magnus J. , Martin‐Matute Belen
Published: July 2016

The preparation of a Pd‐functionalized Fe‐based MOF is described together with its application in the title reaction and its recyclability.
ChemInform Abstract: Design and Synthesis of 2‐Methyl‐7‐aminobenzoxazole as Auxiliary in the Palladium(II)‐Catalyzed Arylation of a β‐Positioned C(sp3)—H Bond.
Authors: Luo Feihua , Yang Jun , Li Zhengkai , Xiang Haifeng , Zhou Xiangge
Published: July 2016

The direct Pd‐catalyzed site‐selective arylation of methylene C(sp3)—H bonds in aliphatic carboxylic amides is developed using 2‐methyl‐7‐aminobenzoxazole (Oxa) as an effective auxiliary.
ChemInform Abstract: A Facile Synthesis of 6‐Amino‐2H, 4H‐Pyrano[2,3‐c]pyrazole‐5‐carbonitriles in Deep Eutectic Solvent.
Authors: Bhosle Manisha R. , Khillare Lalit D. , Dhumal Sambhaji T. , Mane Ramrao A.
Published: July 2016

A one‐pot four‐component cyclocondensation of aromatic aldehydes, malononitrile, ethyl acetoacetate, and hydrazine hydrate affords the title products in high yields within 20 minutes.
ChemInform Abstract: Highly Stereoselective Synthesis of Fluoroalkene Dipeptides via the Novel Chromium(II)‐Mediated Carbon—Fluorine Bond Cleavage/New Carbon—Carbon Bond Formation.
Authors: Nihei Takashi , Nishi Yuji , Ikeda Natsumi , Yokotani Saya , Ishihara Takashi , Arimitsu Satoru , Konno Tsutomu
Published: July 2016

Substrates with Lewis basic groups (e.
ChemInform Abstract: Bio‐Renewable Enantioselective Aldol Reaction in Natural Deep Eutectic Solvents.
Authors: Martinez Regina , Berbegal Lucia , Guillena Gabriela , Ramon Diego J.
Published: July 2016

The deep eutectic solvent formed from D‐glucose and racemic malic acid is a suitable solvent for L‐proline‐catalyzed enantioselective aldol reactions, creating simultaneously a C—C bond and a new stereocenter.
ChemInform Abstract: Transition‐Metal‐Free Cyclopropanation of 2‐Aminoacrylates with N‐Tosylhydrazones: A General Route to Cyclopropane α‐Amino Acid with Contiguous Quaternary Carbon Centers.
Authors: Zhu Chuanle , Li Jiawei , Chen Pengquan , Wu Wanqing , Ren Yanwei , Jiang Huanfeng
Published: July 2016

The title reaction produces a broad spectrum of the desired cyclopropane structures which represent significant motifs in medicinal chemistry.
ChemInform Abstract: Unique Steric Effect of Geminal Bis(silane) to Control the High exo‐Selectivity in Intermolecular Diels—Alder Reaction.
Authors: Liu Zengjin , Lin Xinglong , Yang Na , Su Zhishan , Hu Changwei , Xiao Peihong , He Yanyang , Song Zhenlei
Published: July 2016

Due to the unique steric effect of di(silyl)methyl (DSM) groups, an exo‐selective intermolecular Diels—Alder reaction of geminal bis(silyl) dienes with α,β‐unsaturated carbonyl compounds is achieved.
ChemInform Abstract: Pd(II)‐Catalyzed ortho‐C—H Olefination/Dearomatization of N‐Aryl Ureas: An Approach to Imine Derivatives.
Authors: Jiang Pingping , Xu Yongbao , Sun Fuxing , Liu Xufei , Li Feng , Yu Renfu , Li Yang , Wang Qifeng
Published: July 2016

The reaction of the starting ureas with symmetrical arylalkynes under conditions A) or B) affords spirocyclic imine derivatives.
ChemInform Abstract: An Expedient Approach to Synthesize Aryl‐α‐ketoamides from Acetophenones and N,N‐Dimethylformamide.
Authors: Liu Weibing , Xu Songsen , Chen Cui , Zhu Zhibo
Published: July 2016

The effective oxidative conversion of acetophenones with DMF, serving as dimethylamine surrogate and solvent, furnishes aryl‐α‐ketoamides in presence of copper oxide and iodine.
ChemInform Abstract: Cp*Rh(III)‐Catalyzed Cross‐Coupling of Alkyltrifluoroborate with α‐Diazomalonates for C(sp3)—C(sp3) Bond Formation.
Authors: Lu Yin‐Suo , Yu Wing‐Yiu
Published: July 2016

The trifluoroborate (I) is found to be optimal for the title reaction with diazomalonates (II) and related compounds, where a lot of functional groups are tolerated.
ChemInform Abstract: PdII/CuBr2 Catalyzed Keto α‐C(sp3)—H Benzoxylation of N,N‐Dialkylamides Directed by o‐Hydroxy Groups.
Authors: Santra Sourav Kumar , Banerjee Arghya , Rajamanickam Suresh , Khatun Nilufa , Patel Bhisma K.
Published: July 2016

The Pd‐catalyzed reaction of salicylaldehydes with acetamides and CuBr2 leads to brominated esters such as (III), (V), and (X).
ChemInform Abstract: Oxidation of Thiols to Sulfonic Acids with Oxone®/NaHCO3 and KBrO3.
Authors: Parida Keshaba Nanda , Chandra Ajeet , Moorthy Jarugu Narasimha
Published: July 2016

Good to excellent yields are obtained for the direct conversion of aromatic and aliphatic thiols to sulfonic acids by oxidation with Oxone/NaHCO3.
ChemInform Abstract: Simple and Efficient Methodology to Prepare Guanidines from 1,3‐Disubstituted Thioureas.
Authors: Costa Marcio V. , Cruz de Sequeira Aguiar Lucia , Malta Luiz Fernando B. , Viana Gil M. , Costa Bruno B. S.
Published: July 2016

Desulfurization reactions of thioureas using KICl2 in the presence of amines result in the formation of acyclic and cyclic guanidine salts.
ChemInform Abstract: Benzylic Phosphates in Friedel—Crafts Reactions with Activated and Unactivated Arenes: Access to Polyarylated Alkanes.
Authors: Pallikonda Gangaram , Chakravarty Manab
Published: July 2016

Primary and secondary benzylic phosphates are suitable substrates for the Friedel—Crafts benzylation of arenes giving access to otherwise hardly accessible di‐ and triaryl alkanes.
ChemInform Abstract: An Efficient Synthesis of Bis(indolyl) Methanes and N,N′‐Alkylidene Bis‐amides by Silzic under Solvent Free Conditions.
Authors: Soliman Hanan A. , Mubarak Ahmed Y. , Elmorsy Saad S.
Published: July 2016

Bis(indolyl)methanes are synthesized from indoles and aldehydes or ketones, while bis‐amides are from acetamide and aldehydes.
ChemInform Abstract: Radical Pentafluorosulfanylphenylation of Styrenes by Photoredox Catalysis.
Authors: Li Yanjie , Koike Takashi , Akita Munetaka
Published: July 2016

A broad range of functionalized terminal as well as internal styrene derivatives are efficiently SF5‐phenylated using bench‐stable SF5‐phenyliodonium salts.
ChemInform Abstract: Metal‐Free Radical Oxidative Annulation of Ynones with Alkanes to Access Indenones.
Authors: Pan Changduo , Huang Bifan , Hu Weiming , Feng Xiaomei , Yu Jin‐Tao
Published: July 2016

A benzoyl peroxide promoted direct functionalization of arene C(sp2)—H and alkane C(sp3)—H bonds provides access to indenones.
ChemInform Abstract: Metal‐Free Asymmetric Synthesis of Indanes Through Chiral Hypervalent Iodine(III)‐Mediated Ring Contraction.
Authors: Ahmad Anees , Silva Luiz F. Jr.
Published: July 2016

An iodine(III)‐mediated asymmetric oxidative rearrangement of 1,2‐dihydronaphthalenes gives optically active 1‐substituted indanes.
ChemInform Abstract: Quest for Efficient Catalysts Based on Zinc tert‐Butyl Peroxides for Asymmetric Epoxidation of Enones: C2‐ vs. C1‐Symmetric Auxiliaries.
Authors: Raheem Keeri Abdul , Justyniak Iwona , Jurczak Janusz , Lewinski Janusz
Published: July 2016

Excellent performance is obtained with the C1‐symmetric catalyst (ZNL).
ChemInform Abstract: A Convenient Method for the Synthesis of α‐Carboxylate Ester Bromolactones via Bromolactonization of Alkenoic Diesters.
Authors: Wong Ying‐Chieh , Yeung Ying‐Yeung
Published: July 2016

This NBS‐mediated bromolactonization proceeds well when the diester also bears an alkyl substituent at C1‐position and high diastereoselectivities are obtained when the alkyl substituent is benzyl.
ChemInform Abstract: Intermolecular Radical Carboaminoxylation of Aryl Amines.
Authors: Hartmann Marcel , Gerleve Carolin , Studer Armido
Published: July 2016

The metal‐free, experimentally simple method delivers cyclized alkoxyamines in moderate to high yields.
ChemInform Abstract: Cationic Cobalt(III) Catalyzed Indole Synthesis: The Regioselective Intermolecular Cyclization of N‐Nitrosoanilines and Alkynes.
Authors: Liang Yujie , Jiao Ning
Published: July 2016

A variety of indoles (III), (V), and (VII) is prepared by cyclization of N‐nitrosoanilines with alkynes.
ChemInform Abstract: Highly Efficient Regio and Diastereoselective Synthesis of Functionalized Bis‐Spirooxindoles and Their Antibacterial Properties.
Authors: Ramesh Pambala , Rao Kadiyala Srinivasa , Trivedi Rajiv , Kumar B. Sudheer , Prakasham R. S. , Sridhar B.
Published: July 2016

In this simple method for the preparation of the title compounds, only a small amount of CAN as catalyst is required.
ChemInform Abstract: Mg(ClO4)2‐Promoted [4 + 3] Cycloaddition of Oxindole Derivatives with Conjugated Dienes: Concise Synthesis of Spirocycloheptane Oxindole Derivatives.
Authors: Liu Yun , Sun Zhou , Li Song , Xiang Kuirong , Zhang Yuan , Li Ying
Published: July 2016

The novel cycloaddition route proceeds highly stereoselective affording single diastereomers though in modest yields only.
ChemInform Abstract: Intermolecular Photocatalytic C—H Functionalization of Electron‐Rich Heterocycles with Tertiary Alkyl Halides.
Authors: Swift Elizabeth C. , Williams Theresa M. , Stephenson Corey R. J.
Published: July 2016

The utility of the method is demonstrated by its application in a flow reactor and by the preparation of a biologically active molecule [c.f.
ChemInform Abstract: A Novel and Green Synthesis of Indolone‐N‐Amino Acid Derivatives via the Passerini Three‐Component Reactions in Water.
Authors: Li Rong‐Kun , Yang Quan‐Li , Liu Yi , Li Dong‐Wei , Huang Nian‐Yu , Liu Ming‐Guo
Published: July 2016

The title synthesis is achieved via the reaction of indolyl acetic acid, isocyanides, and aldehydes under mild reaction conditions.
ChemInform Abstract: Substrate‐Controlled Product Divergence: Conversion of CO2 into Heterocyclic Products.
Authors: Rintjema Jeroen , Epping Roel , Fiorani Giulia , Martin Eddy , Escudero‐Adan Eduardo C. , Kleij Arjan W.
Published: July 2016

Optimal reaction conditions are established for the selective conversion of epoxy amines (I) and CO2 into carbamates (III) or carbonates (IV).
ChemInform Abstract: New Efficient Synthetic Routes to Trifluoromethyl Substituted Pyrazoles and Corresponding β‐Diketones.
Authors: Gruenebaum Mariano , Buchheit Annika , Guenther Christina , Wiemhoefer Hans‐D.
Published: July 2016

A simple protocol is presented for the preparation of the title pyrazoles from β‐diketones.
ChemInform Abstract: PEG‐400 as an Efficient and Recyclable Reaction Medium for the Synthesis of 2‐Aryl‐2‐methyl‐4,5‐diphenyl‐2,3‐dihydro‐2H‐imidazoles.
Authors: Penumati Nageshwar Rao , Rajaka Lingayya , Kommu Nagaiah
Published: July 2016

14 Title compounds are prepared in PEG‐400 as solvent without using a catalyst.
ChemInform Abstract: Visible‐Light‐Activated Enantioselective Perfluoroalkylation with a Chiral Iridium Photoredox Catalyst.
Authors: Huo Haohua , Huang Xiaoqiang , Shen Xiaodong , Harms Klaus , Meggers Eric
Published: July 2016

A highly enantioselective perfluoroalkylation of 2‐acyl imidazoles with perfluoroalkyl or perfluorobenzyliodides is described.
ChemInform Abstract: Water‐Assisted Nitrile Oxide Cycloadditions: Synthesis of Isoxazoles and Stereoselective Syntheses of Isoxazolines and 1,2,4‐Oxadiazoles.
Authors: Kesornpun Chatchai , Aree Thammarat , Mahidol Chulabhorn , Ruchirawat Somsak , Kittakoop Prasat
Published: July 2016

Water assisted cycloaddition of nitrile oxides with alkenes and alkynes furnish isoxazoline or isoxazole derivatives, resp, in the absence of any catalyst.
ChemInform Abstract: Synthesis of 2‐Aryl‐2H‐tetrazoles via a Regioselective [3 + 2] Cycloaddition Reaction.
Authors: Patouret Remi , Kamenecka Theodore M.
Published: July 2016

Cycloaddition reaction of diazonium salts (I) with trimethylsilyl diazomethane in the presence of CsF provides desilylated 2‐aryl‐2H‐tetrazoles.
ChemInform Abstract: One‐Pot Synthesis of Ethyl‐3‐aryl‐2‐(1H‐tetrazol‐5‐yl)acrylates and 3‐(1H‐Tetrazol‐5‐yl)coumarins via Tandem [2 + 3] Dipolar Cycloaddition Reaction‐Knoevenagel Condensation.
Authors: Chermahini Zahra Jafari , Chermahini Alireza Najafi , Dabbagh Hossein A. , Teimouri Abbas
Published: July 2016

A one‐pot, three‐component, two‐step, and tandem method is described for the synthesis of tetrazolyl acrylates from aromatic aldehydes.
ChemInform Abstract: Scope and Mechanism of the Highly Stereoselective Metal‐Mediated Domino Aldol Reactions of Enolates with Aldehydes.
Authors: Cinar M Emin , Engelen Bernward , Panthoefer Martin , Deiseroth Hans‐Joerg , Schlirf Jens , Schmittel Michael
Published: July 2016

The one‐pot transformation of ketones (I) and (IV) with aldehydes (II) in the presence of metal halide to furnish tetrahydro‐2H‐pyran‐2,4‐diols (III) and (V), resp., is investigated by experimental and computational studies.
ChemInform Abstract: Enantioselective Synthesis of Dihydrospiro[indoline‐3,4′‐pyrano[2,3‐c]pyrazole] Derivatives via Michael/Hemiketalization Reaction.
Authors: Kumarswamyreddy Nandarapu , Kesavan Venkitasamy
Published: July 2016

The new proline‐derived squaramide organocatalyst is shown to exhibit higher efficiency than known thiourea and squaramide ligands.
ChemInform Abstract: Iron‐Mediated One‐Pot Synthesis of 3,5‐Diarylpyridines from β‐Nitrostyrenes.
Authors: Sathish Manda , Chetna Jadala , Hari Krishna Namballa , Shankaraiah Nagula , Alarifi Abdullah , Kamal Ahmed
Published: July 2016

A convenient one‐pot approach to both symmetrical and unsymmetrical 3,5‐diarylpyridines is reported.
ChemInform Abstract: Copper(II) Triflate‐Catalyzed Aerobic Oxidative C—H Functionalization of Glycine Derivatives with Olefins and Organoboranes.
Authors: Xie Zhiyu , Jia Jiong , Liu Xigong , Liu Lei
Published: July 2016

The Cu‐catalyzed aerobic oxidative C—H functionalization of N‐substituted glycine esters with olefins or potassium organotrifluoroborates is developed to give various quinolines or α‐substituted glycine derivatives, respectively.
ChemInform Abstract: Rh(III)‐Catalyzed Redox‐Neutral Annulation of Primary Benzamides with Diazo Compounds: Approach to Isoquinolinones.
Authors: Wu Youzhi , Sun Peng , Zhang Kaifan , Yang Tie , Yao Hequan , Lin Aijun
Published: July 2016

A novel and efficient route to isoquinolinones via redox‐neutral annulation of primary benzamides with diazo compounds is developed.
ChemInform Abstract: Synthesis of Dimethyl 2‐{1‐[(1‐Methylimidazol‐2‐yl)sulfanyl] ‐1H‐isoquinolin‐2‐yl}but‐2‐enedioate and Related Compounds.
Authors: Kadkhodazadeh Nasrin , Hassanabadi Alireza
Published: July 2016

The title compounds are prepared under mild reaction conditions by simple one‐pot three‐component reaction of acetylenic esters, isoquinoline, and methylimidazolethiol or methyltetrazolethiol as S—H acids.
ChemInform Abstract: BF3·OEt2 Mediated Metal‐Free One‐Pot Sequential Multiple Annulation Cascade (SMAC) Synthesis of Complex and Diverse Tetrahydroisoquinoline Fused Hybrid Molecules.
Authors: Shinde Anand H. , Vidyacharan Shinde , Sharada Duddu S.
Published: July 2016

5‐Bromo‐N3‐Boc‐pyridine‐2,3‐diamine as well as 2‐(N‐Boc‐aminomethyl)aniline as diamino substrates do not give the desired products.
ChemInform Abstract: Formation of C(sp2)—N Bond under Metal‐Catalyst‐Free Conditions for the Synthesis of Pyridopyrazoloquinazoline Derivatives.
Authors: Li Chao , Lu Wen‐Qiang , Zhang Mei‐Mei , Wang Xiang‐Shan
Published: July 2016

The title compounds are prepared by reaction of aminobenzohydrazides with chloropyridinecarbaldehyde involving a subsequent condensation, cyclization, and nucleophilic substitution reaction of the pyridine ring.
ChemInform Abstract: The First Catalytic Application of Oxidized Carbon Nanotubes in a Four‐Component Synthesis of Fused Heterocycles.
Authors: Khodabakhshi Saeed , Rashidi Alimorad , Tavakoli Ziba , Baghernejad Mojtaba , Yadegari Amir
Published: July 2016

Multiwalled carbon nanotubes are oxidized and used as new heterogeneous nanocatalyst in the efficient one‐pot, four‐component synthesis of pyrazolopyranopyrimidinones.
ChemInform Abstract: One‐Pot Regiospecific Synthesis of Quinoxalines via a CH2‐Extrusion Reaction.
Authors: Shen Jinhai , Wang Xiangdong , Lin Xing , Yang Zhenhui , Cheng Guolin , Cui Xiuling
Published: July 2016

Various o‐phenylenediamines and ynones (or diketones) react under metal‐free conditions via formation of intermediate benzodiazepines followed by base‐promoted C‐α‐CH2‐extrusion to produce the desired N‐heterocyclic system.
ChemInform Abstract: Regiospecific Synthesis of Benzoxepines Through Pd‐Catalyzed Carbene Migratory Insertion and C—C Bond Cleavage.
Authors: Xie Yang , Zhang Ping , Zhou Lei
Published: July 2016

A novel method for the synthesis of benzoxepines via regioselective ring expansion is described.
ChemInform Abstract: Tautomerization of 2,6‐Lutidines in the Presence of B(C6F5)3 Using Catecholborane as a Precatalyst.
Authors: Zheng Junhao , Fan Xiaoting , Zhou Benyu , Li Zhen Hua , Wang Huadong
Published: July 2016

The reaction of 2‐methylpyridines (I) with B(C6F5)3 leads to borylated pyridinium derivatives (III), which are used for the Suzuki—Miyaura coupling to afford 2‐benzylpyridines (V).
ChemInform Abstract: Catalytic Selenium‐Promoted Intermolecular Friedel—Crafts Alkylation with Simple Alkenes.
Authors: Tang E. , Zhao Yinjiao , Li Wen , Wang Weilin , Zhang Meng , Dai Xin
Published: July 2016

The title reaction uses TMSOTf as the catalyst and N‐phenylselenophthalimide as the selenium source to afford the selenenylated products in good yields with high regio‐ and diastereoselectivity.
ChemInform Abstract: A Highly Efficient Copper‐Catalyzed Synthesis of Unsymmetrical Diaryl‐ and Aryl Alkyl Chalcogenides from Aryl Iodides and Diorganyl Disulfides and Diselenides.
Authors: Movassagh Barahman , Hosseinzadeh Zhila
Published: July 2016

The reaction has a broad substrate scope.
ChemInform Abstract: Synthesis of (+)‐trans‐Dihydrolycoricidine by an Organocatalytic Enantioselective Friedel—Crafts Reaction
Authors: Kato Masaru , Yasui Koji , Yamanaka Masahiro , Nagasawa Kazuo
Published: July 2016

as a key step
ChemInform Abstract: Quinolizidine‐Based Alkaloids: A General Catalytic, Highly Enantio‐ and Diastereoselective Synthetic Approach.
Authors: Lindemann Chris , Schneider Christoph
Published: July 2016

A series of quinolizidine‐based alkaloids, e.
ChemInform Abstract: Genetic Engineering of Inorganic Functional Modular Materials
Authors: Li Yi , Yu Jihong
Published: July 2016

Review: 95 refs.
ChemInform Abstract: Metal‐Free Carbonaceous Electrocatalysts and Photocatalysts for Water Splitting
Authors: Xu You , Kraft Markus , Xu Rong
Published: July 2016

Review: tutorial review; 52 refs.
ChemInform Abstract: Synthesis and Application of Monolayer Semiconductors (June 2015)
Authors: Chiu Kuan‐Chang , Zhang Xin‐Quan , Liu Xiaoze , Menon Vinod M. , Chen Yung‐Fu , Wu Jenn‐Ming , Lee Yi‐Hsien
Published: July 2016

Review: e.g. MoS2 and WS2; 95 refs.
ChemInform Abstract: Magnetism in Cubic Manganese‐Rich Heusler Compounds
Authors: Wollmann Lukas , Chadov Stanislav , Kuebler Juergen , Felser Claudia
Published: July 2016

Review: 61 refs.
ChemInform Abstract: Hierarchy Concepts: Classification and Preparation Strategies for Zeolite Containing Materials with Hierarchical Porosity
Authors: Schwieger Wilhelm , Machoke Albert Gonche , Weissenberger Tobias , Inayat Amer , Selvam Thangaraj , Klumpp Michael , Inayat Alexandra
Published: July 2016

Review: 204 refs.
ChemInform Abstract: Chiral Chemistry of Metal—Camphorate Frameworks
Authors: Gu Zhi‐Gang , Zhan Caihong , Zhang Jian , Bu Xianhui
Published: July 2016

Review: synthetic approaches and chiral chemistry of metal‐camphorate frameworks; 142 refs.
ChemInform Abstract: Solid State Physicochemical Properties and Applications of Organic and Metallo‐ Organic Fullerene Derivatives
Authors: Mitsari Efstratia , Romanini Michela , Zachariah Manesh , Macovez Roberto
Published: July 2016

Review: 240 refs.
ChemInform Abstract: Recent Advances in Iron‐Catalyzed Cross Coupling Reactions and Their Mechanistic Underpinning
Authors: Mako T. L. , Byers J. A.
Published: July 2016

Review: 106 refs.
ChemInform Abstract: Reactivity of Indolizines in Organic Synthesis
Authors: Elattar Khaled M. , Youssef Ibrahim , Fadda Ahmed A.
Published: July 2016

Review: 104 refs.
ChemInform Abstract: Fe3O4 (Iron Oxide)‐Supported Nanocatalysts: Synthesis, Characterization and Applications in Coupling Reactions
Authors: Sharma Rakesh K. , Dutta Sriparna , Sharma Shivani , Zboril Radek , Varma Rajender S. , Gawande Manoj B.
Published: July 2016

Review: 292 refs.
ChemInform Abstract: Coupling Carbon Dioxide Reduction with Water Oxidation in Nanoscale Photocatalytic Assemblies
Authors: Kim Wooyul , McClure Beth Anne , Edri Eran , Frei Heinz
Published: July 2016

Review: 206 refs.
ChemInform Abstract: Organizing Multivalency in Carbohydrate Recognition
Authors: Mueller Christian , Despras Guillaume , Lindhorst Thisbe K.
Published: July 2016

Review: [98 refs.
ChemInform Abstract: Asymmetric Copper‐Catalyzed Azide‐Alkyne Cycloadditions
Authors: Brittain William D. G. , Buckley Benjamin R. , Fossey John S.
Published: July 2016

Review: 70 refs.
ChemInform Abstract: Manganese‐Catalyzed C—H Activation
Authors: Liu Weiping , Ackermann Lutz
Published: July 2016

Review: use of manganese complexes in substitution and annulation reactions of arenes nvolving directed C‐H activation; 167 refs.
ChemInform Abstract: Metal and Metal Oxide Nanoparticles: A Lever for C—H Functionalization
Authors: Pla Daniel , Gomez Montserrat
Published: July 2016

Review: 119 refs.
ChemInform Abstract: Overview of the Characteristic Features of the Magnetic Phase Transition with Regards to the Magnetocaloric Effect: The Hidden Relationship Between Hysteresis and Latent Heat
Authors: Morrison Kelly , Cohen Lesley F.
Published: July 2016

Review: 36 refs.
ChemInform Abstract: Surface Magnetism of NiO Investigated by Magnetic Spectromicroscopies
Authors: Mandal Suman , Das Jayanta , Menon Krishnakumar S. R.
Published: July 2016

Review: 64 refs.
ChemInform Abstract: How Much Successful Are the Medicinal Chemists in Modulation of SIRT1: A Critical Review
Authors: Kumar Ashwani , Chauhan Shilpi
Published: July 2016

Review: 203 refs.
ChemInform Abstract: Molecular and Digital Biomarker Supported Decision Making in Clinical Studies in Cardiovascular Indications
Authors: Kramer Frank , Dinh Wilfried
Published: July 2016

Review: 65 refs.
ChemInform Abstract: A Toolbox of Building Blocks, Linkers and Crystallization Methods Used to Generate Single‐Chain Magnets
Authors: Dhers Sebastien , Feltham Humphrey L. C. , Brooker Sally
Published: July 2016

Review: 155 refs.
Kinetic behaviours of carbon dioxide and carbon monoxide on carbon molecular sieve
Authors: Shirani Babak , Eic Mladen
Published: July 2016

A carbon molecular sieve (CMS) is a carbonaceous material with a narrow pore size distribution, which can separate molecules based on their size, shape, and adsorption kinetic rate. In this study, a commercial CMS was used to measure the adsorption kinetics of carbon dioxide and carbon monoxide. The rate of adsorption was investigated by considering two main resistances, surface barrier and diffusion. The results showed that molecular parameters, such as difference in shape, size, and interactions of molecules, lead to different adsorption kinetics mechanisms. In the system investigated in this study, the adsorption kinetics of both CO2 and CO sorbates were controlled by combined diffusion and surface barrier mechanisms, in which the surface barrier was found to be the main resistance to gas molecule uptake. Even though this study confirmed surface resistance as a dominant transfer mechanism, the systematic use of the combined model in the analysis provided further insights in the mass transfer due to adsorption of CO2 and CO molecules in the CMS adsorbent.

The rate constants were found to follow the Darken equation for both sorbates. The kinetic selectivity of CO2 over CO was calculated from the combined surface barrier/diffusion model parametric analysis. The results generally showed a greater selectivity to carbon dioxide over carbon monoxide, i.e. higher mass transfer rates.