bluuebunny/crossref_metadata_2025 huggingface dataset:
Olsenella intestinalis sp. nov., isolated from cow feces
Authors: Guan Yong , Li Zhun , Kim Min-Ju , Lee Jae-Young , Choe Hanna , Park Seung-Hwan , Kang Se Won , Lee Jiyoung , Lee Ju Huck , Kim Hyeun Bum , Lee Ju-Hoon , Kim Eunju , Lee Mi-Kyung
Published: April 2022

A Gram-stain-negative, anaerobic, non-motile, rod-shaped bacterium, designated as BGYT1T, was isolated from the feces of a cow in Andong, Republic of Korea. It was studied by using a polyphasic method to determine its taxonomic position. Phylogenetic analysis based on 16S rRNA gene sequences revealed that strain BGYT1T formed a lineage within the genus Olsenella and was most closely related to O. umbonate KCTC 15140T (98.24%). The complete genome sequence of strain BGYT1T was 2,476,083 bp long with a G+C content of 66.9 mol%. The values for ANI (76.8%), AAI (67.26%), and dDDH (22.2%) compared to the closest related species were all below the threshold for bacterial species delineation. The strain was able to grow at pH 6.0-8.0 (optimum, pH 7.0), in the presence of 0.5-1.5% NaCl (optimum, 0.5%, w/v) and at the temperature range of 35-40°C (optimum, 35°C). The predominant fatty acids were C16:0 DMA (20.15%), C16:0 (20.15%), C18:0 (10.54%) and C18:1 cis 9 (16.99%). The polar lipid profiles contained phospholipid, glycolipid and five unidentified glycolipids. Based on its phenotypic analyses, phylogenetic and physiological characteristics, strain BGYT1T represented a novel species within the genus Olsenella, for which the name Olsenella intestinalis sp. nov. is proposed. The type strain is BGYT1T (=KCTC 25379T=GDMCC 1.3011T).
Observation of a spin chirality driven topological transition in a van der Waals magnet
Authors: Nambu Yusuke , Aoyama Kazushi , Kawamura Hikaru , Gentile Thomas , Chen WangChun , Watson Shannon , Ye Qiang , Qiu Yiming
Published: April 2022

Low-dimensional magnetism has long been the central issue in condensed matter physics, and van der Waals materials provide an ideal platform for exploring magnetism at the two-dimensional limit. The magnetic order in two-dimensional model materials is suppressed, and arguments based upon topology are useful for describing phases of matter. An example is the Berezinskii-Kosterlitz-Thouless transition where spin correlations over long distances eventually give rise to magnetic order; thus has never been realised experimentally in magnetic materials. A similar topological transition with vortices by chirality, handedness of the electronic spin arrangements, is possible without inducing any order; however, evidence for this higher-order vortex dissociation transition remains elusive. Here, we combine polarised neutron scattering and theoretical simulations to show that the transition occurs in a van der Waals magnet. We experimentally observe in-plane and out-of-plane spin moments, and their ratio, the spin-state anisotropy, shows a tendency for reversal across an anomalous temperature. Our simulations confirm the experimental findings; the tendency cannot be reproduced when removing the chiral vortices. The chirality-driven topological transition is general but has been challenging to be detected. Our results set a new paradigm for revealing topological characteristics with a higher-order degree of freedom.
Assessment of Ground Water Quality in Woreillu town, Ethiopia
Authors: Asfaw Melese Damtew
Published: April 2022

Water Quality Index of Woreillu town ground water was determined using Weight Arithmetic WQI method to assess the suitability of the ground water for drinking purposes as per WHO prescribed guidelines. The groundwater samples were collected from selected locations within one-year-monitoring period from January to August 2019. All the laboratory measurements of the physical, chemical and heavy metal parameters were measured using the standardized method. The WQI of the study ground water was established from ten physicochemical parameters (temperature, pH, Conductivity, Turbidity, Total alkalinity, TDS, TH, Nitrate, Phosphate, and Sulphate) and five heavy metals (Fe, Cu, Pb, Mn and Zn). The result showed that all physical and chemical parameters were almost below the maximum allowable level based on the WHO standards for drinking. On the other hand, the lead (Pb) was exceeded the maximum allowable limit in all the studied locations based on the WHO standards for drinking water. The computed WQI values range from 49 to 136. Therefore, out of 5 studied locations, one location was classified in the “Excellent water” class, one location as a “Good water” class, three as a “Poor water” class. Furthermore, lead, ph and turbidty were considered the most effective parameter on the determination of WQI in this study. The study revealed that only a few of the values for the heavy metals and physico-chemical parameters of the water samples were above the tolerable limits recommended by the WHO. This calls for regular monitoring and purification of boreholes to ensure good water quality.
Topological characterization for the geometric origin of transition in electrical conductivity for hybrid nanocomposites
Authors: Lee Jungmin , Lee Sang Hyun , Hwang Jinyoung
Published: April 2022

In this study, the analytical relationship between the electrical conductivity of hybrid nanocomposites consisting of conducting nanowires and insulating particulate fillers was investigated. We measured the performance as a function of the major factors defined by the combination of physical parameters of the constituent fillers. The major factors were identified using data mining techniques. The topological structure of the nanocomposites was described using a combination of Voronoi tessellation and the Swiss cheese model. Based on the geometrical framework, an analytical model of the electrical conductivity of the hybrid nanocomposites was built based on the Kozeny–Carman approach. The model delineates a one-dimensional characterization of the transition in electrical conductivity associated with the size ratio of the fillers and enables to visualize the quantitative relationship between the topological structure and electrical conductivity of the hybrid nanocomposites. Formalism facilitates the design of the physical properties of hybrid nanocomposites before their synthesis.
Association of physical activity on the academic performance of undergraduate physiotherapy students at Sindh Institute of Physical Medicine and Rehabilitation.
Authors: Awan Tabeer Tanwir , Awan Tamseel Tanwir , Awan Imtesaal Tanwir , Khalid Farah
Published: April 2022

Background:
Despite the health and wellness outlook of physical activity, the number of studies that associate physical activity, and academic performance has been increased. Modern research has described the involvement of physical activity on academic performance of students at primary, secondary, and university levels which may be influenced by upgrading in attention, administrative functions, and work memory because of increased blood circulation and neurogenesis by performing physical activity. This study aimed to evaluate the association of physical activity on the academic performance of undergraduate physiotherapy students at Sindh Institute of Physical Medicine and Rehabilitation.
Methods:
This was an observational, cross-sectional study conducted in June 2021 at Sindh Institute of Physical and Medicine Rehabilitation. Undergraduate DPT students from the second year till the fifth year enrolled in Sindh Institute of Physical Medicine and Rehabilitation were taken in the study. Data collection was done by using non-probability purposive sampling for the sample size of 365 DPT students. Α self-administered web-based survey questionnaire was used to collect data. Data were analysed on SPSS program Version 20. By using descriptive statistic age, gender, and study year was analysed. The mean difference of the scores derived from IPAQ with gender and study year were assessed through parametric tests. The relationship of physical activity with academic performance was investigated through the non-parametric test of Chi-square.
Results:
The mean difference of IPAQ scores did not show much difference between the two genders to have a better physical activity level than the other (p-value: 0.772). There was no significant difference between study years with total physical activity scores (p-value: 0.158). According to cross-tabulation, 50% of students who had a GPA around the 2.1-3.0 range and 51.70% who had a GPA around the 3.1-4.0 range were classified in low activity level. Therefore, we conclude that a non-significant association between physical activity and academic performance was found among undergraduate physiotherapy students in SIPMR.
Conclusion:
The deduction to our research is that there was no link between physical activity with academic performance. Along with that, there was no evidence found in the current study about either gender being more physically active than others. Students from all the years in SIPMR had the same level of activity level and there was no significant difference found.
New evidence of the emergence of East Asian monsoon in the early Palaeogene: A palynology perspective from central China
Authors: Zhang Qianqian , Su Lifei , Sun Yankun , Zhang Shaoliang , Smith Thierry , Li Chengsen
Published: April 2022

Earlier palaeoenvironmental reconstructions implied that East Asia climates were dominated by a zonal climate pattern during the Eocene, with an almost latitudinal arid/semiarid band around ~ 30° N paleolatitudes. However, this long-standing model has recently been challenged by growing multidisciplinary evidence. Some previous studies indicated that the middle part of what is now China had was characterized by climatic fluctuations between humid and relatively dry during the Early Eocene, akin to present East Asian monsoon regimes (EAM). Therefore, whether the EAM existed in the Early Eocene has been under much attention and debate in the scientific community. Using palynological assemblages in the Tantou Basin, central China, we quantitatively reconstructed climate changes from the Late Palaeocene to the Early Eocene to better understand climate change in East Asia. The palynological assemblages revealed that the coniferous and broad-leaved mixed forest in this area received no less than 800 mm of annual precipitation and experienced a climate change process from warm and wet to relitively cool and dry. According to palaeoclimate change curves, sudden climate change occurred in the Early Eocene, with mean annual temperature and MAP decreasing by 5.1 ℃ and 214.8 mm, respectively to become very similar to the present climate which controlled by monsoon climate. So, we inferred that this significant climate change during the Early Eocene may signal the emergence of the EAM in East Asia.
Central positional vertigo as first initial multiple sclerosis symptom: a case report with systematic review.
Authors: Meshref Mostafa , Shaheen Ahmed , Elmatboly Abdelmagid M. , Abdella Walid Shaban , Amro Yara , Khairat Shiamaa M. , Swed Sarya
Published: April 2022

Multiple sclerosis is a disease that affects the central nervous system, resulting in a variety of symptoms such as vision, physical activity and stability. Central positional vertigo as an initial multiple sclerosis symptoms is a rare case in the literature.
Systematic identification of cell fate regulatory programs using a single-cell atlas of mouse development
Authors: Fei Lijiang , Chen Haide , Ma Lifeng , E Weigao , Wang Renying , Fang Xing , Zhou Ziming , Sun Huiyu , Wang Jingjing , Jiang Mengmeng , Wang Xinru , Yu Chengxuan , Mei Yuqing , Jia Danmei , Zhang Tingyue , Han Xiaoping , Guo Guoji
Published: April 2022

Waddington’s epigenetic landscape is an abstract metaphor frequently used to explain cell fate decisions. Recent advances in single-cell genomics are altering our understanding of the Waddington landscape. Yet, the molecular regulations behind remain poorly understood. We construct a dynamic cell landscape of mouse lineage differentiation at the single-cell level and thereby reveal both lineage-common and lineage-specific regulatoryprograms during cell type maturation. We verify lineage-common regulatory programs that are universal during the development of invertebrates and vertebrates. In particular, we identify Xbp1 as an evolutionarily conserved regulator of cell fate determinations across different species. We demonstrate that Xbp1 transcriptional regulation is important for the stabilization of the genetic network for a wide range of cell types. Our results offer genetic and molecular insights into the gene regulatory programs systematically and provide resources to advance the understanding of the cell fate decisions.
Proposal for realizing anomalous Floquet insulators via Chern band annihilation
Authors: Zhang Carolyn , Holder Tobias , Lindner Netanel , Rudner Mark Spencer , Berg Erez
Published: April 2022

Two-dimensional periodically driven systems can host an unconventional topological phase unattainable for equilibrium systems, termed the Anomalous Floquet-Anderson insulator (AFAI). The AFAI features a quasi-energy spectrum with chiral edge modes and a fully localized bulk, leading to non-adiabatic but quantized charge pumping.
Here, we show how such a Floquet phase can be realized in a driven, disordered Quantum Anomalous Hall insulator, which is assumed to have two critical energies where the localization length diverges, carrying states with opposite Chern numbers. Driving the system at a frequency close to resonance between these two energies localizes the critical states and annihilates the Chern bands, giving rise to an AFAI phase.
We exemplify this principle by studying a model for a driven, magnetically doped topological insulator film, where the annihilation of the Chern bands and the formation of the AFAI phase is demonstrated using the rotating wave approximation.
This is complemented by a scaling analysis of the localization length for two copies of a quantum Hall network model with a tunable coupling between them.
We find that by tuning the frequency of the driving close to resonance, the driving strength required to stabilize the AFAI phase can be made arbitrarily small.
CLINICAL PROFILE AND SURGICAL MANAGEMENT OF ABDOMINAL HYDATID DISEASE IN ADULTS
Authors:   Professor, Department of Surgery, GMC Srinagar., Mushtaq Ahmad Shah Syed , Manzoor Khan Ahlam ,   Postgraduate, Department of Surgery, GMC Srinagar., Ahmad Aijaz ,   Postgraduate, Department of Surgery, GMC Srinagar., Mohammad Khandwaw Haseeb ,   Senior-Resident, Department of Surgery, GMC Srinagar.
Published: April 2022

Introduction: Hydatid disease is a disease that has been known since antiquity and was described by Hippocrates with the particular term Liver filled with water followed by famous Arabian physician Al-rhazes who wrote on hydatid cyst of liver about 1000 years ago. Hydatid disease commonly known as Cystic Echinococcosis (CE) is a parasitic infestation caused by flatworm Echinococcus granulosus. Hydatid disease is characterized by cystic lesions occurring in different parts of body most commonly liver (65%), lungs (15%). Unusual sites of involvement include muscles (5%), bones (5%),kidney (3%), spleen (2%), diaphragm (1%), ovary (0.2%).The peritoneal cavity, thyroid, breast, gall bladder, omentum are rarely involved. Methods: Our study was a prospective observational study conducted in Postgraduate Department of General Surgery, Government Medical College, Srinagar, J&K for a period of 2 years. This study included 30 patients after fulfilment of inclusion and exclusion criteria. Ethical clearance was obtained from institutional Ethical Committee. Results: In this study 30 cases of hydatid disease were studied, the most common age group involved in this disease was 21-30 years. . Most of our patients were females 18 cases (60%) and males 12 cases (40%). Male: Female ratio of our study is 1:1.5. Majority of patients presented with abdominal pain 24 cases (80%) followed by vomiting in 5 cases (16.7%), palpable mass was found in 1 case (3.3%) and Jaundice in 1 case (3.3%). Laparoscopic hydatid cystectomy for hydatid liver was done in 10 cases (33.3%). Open hydatid cystectomy was done in 17 cases (56.7%). Conclusion: Hydatid disease can occur in any age group but is seen most commonly in middle age , females, patients belonging to low socioeconomic status and involved in farming. Low socioeconomic status, agricultural activities and association with dogs or cattle were risk factors for the disease. Absence of history of contact with cattle or dogs doesnt rule out the possibility of disease.
ENGLISH LANGUAGE AS A NEED OF PRESENT EDUCATION SYSTEM AND BUSINESS
Authors:   Assistant Professor of English Government Post Graduate Lead College Sheopur, Madhya Pradesh., Khan Javed
Published: April 2022

It has a great influence over every organization that without English language, no any business organization can work globally and the managers of the organization can not represent their work at the global platform. As English is also the part of business communication and it can be said undoubtedly that if any owner of any business organization cannot communicate in English language, so his /her business will not get global exposure. The reasons of the failure of his/her will be not to have a good command over English language like the business man does not know how to write an email, writing business letter, preparing a business report and giving presentation for the promotion of the business. Many organizations train their employees for the effective working of the organization like they are imparted the training of soft skills, personality development and communication skills. Effective communication skills are a daily part of business communication because conducting meeting and solving problems related to any issue of the organization is the daily responsibility of every employees that if they wish to increase the productivity of their company. They need to solve the problems and represent their views with effective manner. It has been observed that in the corporate world those who have a good command over English language are given importance and their thoughts and views have a power of persuasion Even if we talk about the clerical staff of the organization, employee who have a good command over English language their views and thoughts are given importance and they are listened carefully and when they participate in any meeting they are considered as an effective employee of the organization and they get salary hike and promotions early in their career and because of their English language skills they get better career opportunity comparatively other employees in the same and in different organizations. In the present scenario of business world no any organization considers the candidate if he does not have a working knowledge of English language even if he has a good marks in his/her academics. the reason is that good marks and degree is like a key to unlock the door of business world but the candidates will have to work for the organization and most of the time candidate has a good academic career but fails to work effectively thats the reason getting the knowledge of business in college and in any academic organization its difficult but by doing it practically. So if we believe in the concept English language and the power of soft skills that candidate has no any Masters degree in business even then he can work with the help of his/her skills.
IMPACT OF URBAN DISCHARGES FROM THE TOWN OF ADZOPE ON THE MASSAN RIVER WATER RESERVOIR USED FOR THE PRODUCTION OF WATER FOR HUMAN CONSUMPTION (SOUTH-EAST OF COTE DIVOIRE)
Authors:   Laboratory of Soil, Water and Geomaterials Sciences (LSSEG), University Felix Houphouet-Boigny, Training and Research Unit for Earth Sciences and Mineral Resources -Abidjan (Cote dIvoire)., Noel Keumean Keiba , Soro Gbombele ,   Laboratory of Soil, Water and Geomaterials Sciences (LSSEG), University Felix Houphouet-Boigny, Training and Research Unit for Earth Sciences and Mineral Resources -Abidjan (Cote dIvoire)., Yolande Esther Body Apo ,   Laboratory of Soil, Water and Geomaterials Sciences (LSSEG), University Felix Houphouet-Boigny, Training and Research Unit for Earth Sciences and Mineral Resources -Abidjan (Cote dIvoire)., Soro Nagnin ,   Laboratory of Soil, Water and Geomaterials Sciences (LSSEG), University Felix Houphouet-Boigny, Training and Research Unit for Earth Sciences and Mineral Resources -Abidjan (Cote dIvoire).
Published: April 2022

The town of Adzope, in the southeast of Cote dIvoire is faced with a sanitation problem, the direct consequence of which is the untreated discharge of wastewater into the Massan River reservoir. The objective of this work is to carry out a physico-chemical characterization of urban wastewater in the town of Adzope. This characterization of urban wastewater is a good indicator of the quality of discharges and their impact on the receiving environment. The pH, temperature, electrical conductivity (EC) and dissolved oxygen (O2) were measured in situ using a multi-parameter HANNA HI 9829. In the laboratory, the various physico-chemical parameters were analysed according to the analysis methods recommended by the French Association for Standardization. The results obtained show that the parameters studied (T, pH, EC, DO, COD, DOB5, TSS, NH4, NO3, PO4 and Cl) have variable contents from one site to another. Most of the parameters studied comply with the discharge standards established by Ivorian legislation, except suspended particles and phosphate ions. These two parameters have values that exceed the established standards. Thus, the discharge of this wastewater into the Massan River reservoir can lead to eutrophication.
AN ADAPTED UNMANNED AERIAL VEHICLE FOR ENVIRONMENTAL WATER SAMPLING
Authors: Neto José , Resque Ian , Avelino Rodrigo , dos Santos Vagner , Leite Lucas , Cesar Lucas , da Silva Belo Paulo , Albuquerque Jones , de Lima Filho José
Published: April 2022

In this work an unmanned aerial vehicle (UAV) was adapted to be used as an environmental tool to collect water samples of sea, estuary, and mangrove for further analysis by gas chromatography with a mass detector (GC-MS). The sampling automated system was based on a microcontroller, a solenoid valve, and a peristaltic mini-pump that was coupled to a quadcopter UAV. The apparatus was properly calibrated to acquire 100 mL of environmental water at 4.6 min. After, the concentration of BTEX (benzene, toluene, ethylbenzene, and o, m, p-xylenes) was analyzed in laboratory using GC-MS and the BTEX concentration ranged from 0.3 to 5.0 µg L-1 with a recovery from 83.9 to 118% with a relative standard deviation lower than 7.0%. Tests of cross-contamination were performed by simultaneous sampling and laboratory blank was carried out and no contamination was found for BTEX analysis. Based on the results, the adapted UAV presented a very useful ability to collect samples in difficult access areas such as mangroves, points between rocks, corals reefs, without health risk and without impacting the fragile ecosystem being an interesting tool for environmental purposes.
Prospective Goals and Objectives of the Kuzbass Chemical Industry Development Strategy
Authors: Tkachenko Sergey , Tkachenko Il'ya , Kalmykov Stepan , Egorova Angelina
Published: April 2022

The article features various strategizing issues of chemical industry. The authors summarize prospective strategic goals and objectives of the chemical industry in the Kemerovo Region (Kuzbass). They believe that proper strategic objectives in the chemical industry development can help the region to overcome the current economic recession. The paper contains some recommendations on how to implement Industry 4.0 in the chemical industry and develop the local chemical industry by creating large, medium, and low-tonnage chemical enterprises.
Business Transition to ESG-Strategies: Innovative Approaches in Russian and International Experience
Authors: Nikonorov Sergey , Papenov Konstantin , Talavrinov Vladimir
Published: April 2022

Sustainable development is one of the priority areas of business development strategies in Russia and abroad. Sustainable development is focused on environmental protection but takes into account certain social aspects. If a company wishes to implement a more environmentally friendly, social, and economically sustainable structure, it needs a complete set of required documentation and instructions. This documentation is based on environmental, social, and governance criteria, which together form the ESG-strategy.
Adsorption of levofloxacin on natural zeolite: effects of ammonia nitrogen and humic acid
Authors: Chi Xiaoying , Zeng Lixuan , Du Yuejin , Huang Jiaquan , Kang Yuan , Luo Jiwen , Zhang Qiuyun
Published: April 2022

The persistence of antibiotics in sewage treatment plants in recent years has become a serious problem. Meanwhile, humic acid and ammonia nitrogen are widely distributed in natural reservoirs and might influence the sorption, migration and transformation of antibiotics. In this study, natural zeolite (NZ) was evaluated as an adsorbent for the removal of levofloxacin (LEV). The physical and chemical properties of NZ before and after adsorption were characterized by various analytical techniques to develop the mechanism. The effects of ammonia nitrogen and humic acid (HA) on the interfacial behavior of LEV on NZ were explored. Comparative experiments revealed that LEV adsorption on NZ involved electrostatic interactions and ion exchange, and the adsorption processes were well fitted by the Langmuir isotherm model and pseudosecond-order kinetic model. The maximum experimental adsorption capacity of LEV was 22.17 mg·g−1 at pH 6.5. The presence of ammonia nitrogen and HA significantly suppressed the adsorption of LEV due to competitive adsorption, and the adsorption capacity decreased 58 and 46%, respectively. It is obvious that low concentrations of ammonia nitrogen and HA are conducive to improving the treatment effect of sewage. This study demonstrates that NZ is a promising and efficient material for LEV adsorption.
Identification of Immune Infiltration and Prognostic Biomarkers in Small
Cell Lung Cancer Based on Bioinformatic Methods from 3 Studies
Authors: Yu Changhua , Cao Jiaoyan
Published: April 2022

Aims:

This study aimed to investigate the correlation between gene expression and immune
cell infiltration and the overall survival rate in tumor tissues, which may contribute to the
therapy and prognosis of small cell lung cancer (SCLC) patients.

Background:

SCLC is the most aggressive type of lung neoplasm. There is no proper marker for
the treatment and prediction of prognosis in SCLC.

Objectives:

Three gene expression profiles of SCLC patients were obtained from the Gene Expression
Omnibus (GEO) database. Differentially expressed genes (DEGs) were identified between
normal lung samples and SCLC lung samples.

Methods:

Functional enrichment analysis of all DEGs was performed to explore the linkage among
DEGs, the tumor immune microenvironment, and SCLC tumorigenesis. The common genes among
the 3 groups in the Venn diagram and hub genes in protein-protein interaction (PPI) networks were
considered potential key genes in SCLC patients. The TIMER (tumor immune estimation resource)
database calculation and Kaplan–Meier survival curves were used to investigate the association between
potential key genes and immune infiltrate prognosis of SCLC patients.

Results:

A total of 750 (top 250 from each study) differentially expressed genes (DEGs) were
identified. CLDN18 and BRIP1 were significantly related to immune infiltration in the tumor microenvironment.
SHCBP1 and KIF23 were related mostly to prognosis in SCLC patients.

Conclusion:

The present study may provide some potential biomarkers for the therapy and prognosis
of SCLC.
Synthesis, Antimicrobial Activity, and Molecular Modeling Studies of
Some Benzoxazole Derivatives
Authors: Muhammed Muhammed Tilahun , Kuyucuklu Gulcan , Kaynak-Onurdag Fatma , Aki-Yalcin Esin
Published: April 2022

Background:

The need to develop novel antimicrobial agents is apparent as infectious diseases
are increasing and resistance is rapidly developing against the drugs used in the treatment.

Objective:

This study aimed at the synthesis, antimicrobial susceptibility testing, and computational elucidation
of the mechanism of action of benzoxazole derivatives. It also aimed to compare the results obtained
in this study with the previous studies by our group. This would pave the way for designing novel
molecules with better antimicrobial activity. The other goal was pharmacophore analysis and in silico
ADMET analysis of them.

Methods:

In this study, synthesis, antimicrobial susceptibility testing, molecular docking, pharmacophore
analysis, and ADMET prediction were carried out.

Results:

The antimicrobial activity studies demonstrated that the synthesized compounds were active
against standard strains and clinical isolates at high concentrations. Then, the antimicrobial testing results
were compared to similar benzoxazoles tested by our group previously. Benzoxazole derivatives without
a methylene bridge between oxazole and phenyl ring were found to be more active than those with the
methylene bridge. This was also confirmed by molecular modeling undertaken in this study. The computational
results indicated that the antibacterial activity could be achieved by DNA gyrase inhibition.
Pharmacophore analysis showed that hydrogen bond acceptor (HBA), hydrogen bond donor (HBD), and
hydrophobicity features would contribute to the inhibition. In addition, in silico ADMET property investigation
of the compounds exhibited that they had the desired pharmacokinetics.

Conclusion:

Although antibacterial activity by inhibiting DNA gyrase is selective, the synthesized compounds
were active at much higher concentrations than the standards. Therefore, in prospective antimicrobial
studies, it is better to focus on benzoxazole derivatives without the methylene bridge. Since the
compounds had suitable in silico ADMET properties, screening them against the other pharmacologic
activities should be carried out. It is recommended to support the molecular modeling results with in vitro
or in vivo studies.
Evaluation of Prescribing Pattern, Therapeutic Adherence and Occurrence
of Adverse Drug Reactions in Patients with Type 2 Diabetes Mellitus
Authors: Akhtar Md. Sayeed , Sharma Manju , Sani Sanusi , Kapur Prem , Sharma Gunjan , Tabassum Fauzia , Khan Mohd Faiyaz
Published: April 2022

Background:

Persistent hyperglycemia in diabetes mellitus (DM) is considered the leading
cause of morbidity and mortality associated with both microvascular and macrovascular complications,
having a greater economic impact. This study aimed to assess the impact of socioeconomic status,
prescribing patterns, and patient compliance in type 2 diabetes mellitus patients.

Method:

This study was carried out at the Department of Medicine and Diabetic Clinic of Hakeem
Abdul Hameed (HAH) Centenary Hospital at Hamdard University, New Delhi, India. We conducted a
prospective observational study on prescribing patterns and monitoring adverse drug reactions (ADRs)
in patients with type 2 DM (T2DM) under standard care. We enrolled 150 confirmed cases, and data
was obtained from pre-validated questionnaires and then coded and analyzed to observe the association
between variables.

Results:

The glycosylated haemoglobin level in 56% of the cases was between 6.4 to 8.0, and cardiovascular
complications were observed as the major comorbidities. 45.33 % of the cases were on mono
drug therapy, and metformin (23. 52 %) was the drug of choice, followed by glimepiride (23.52 %).
Among the dual drug therapies, sitagliptin with metformin and triple-drug therapy, glimepiride concurrent
with metformin and voglibose was the most preferred drug in the treatment of T2DM.
Sitagliptin was observed to be a major patient burden (46.213 USD). In only 7.33 % of the cases, we
observed definite ADR in T2DM patients. Underprivileged awareness, mainly due to low literacy, was
a major concern in the development of new cases of T2DM.

Conclusion:

We observed better patient compliance; however, a disease awareness program must be implemented.
The use of oral hypoglycaemic drugs is still dominant in clinical practice and cardiovascular
disorders as comorbidities emerge as a greater challenge in terms of patient outcome and cost burden.
In regards to applicability of civil rights protection in medicinal trade on IT-platforms
Authors:   A.Y. Rozhkova Pskov State University, Rozhkova A.Y.
Published: April 2022

The article substantiates to break the dominance of administrative legal forms of protection by introducing platform tools in the applicability of civil legal forms of consumer protection. The key problems of the pandemic relate to the production of new vaccines as socially important commodities, where their quality and safety as guarantor of public health are regulated by a set of legal norms. Asked about useful public effect of public defense to restitute of civil rights to the medicines available, about the law risks of the dominance of restrictions and fiscal penalties, where public consumer defense dominates in the Coved crisis; the predictability of the limits and consequences of public law restrictions. The judicial analysis proves that there is no legislative mechanism of the civil-law property on the sale of drugs as "consumption of goods". By interpreting the features, identified, that the civil-law mechanism is applicable to contractual legal relations on the provision of information services on the use of medicines and consumer protection representation services; the administrative-law mechanism is applicable to the " the consumption" of drugs. Analysis the judicial practice reveals an administrative application measures to restitute legality, where is a dominance of fiscal function, which creates a risk to defending rights and failing, so balance private and public law. Conclusions have relevance to develop of civil legal relations based on technological digital tools of online and web-based e-commerce of medicines to applicant the alternative forms of defense and remedy for consumers' civil rights.
Játékosjog vásárlások hatása a vállalatértékelésre a labdarúgás világában
Authors: Bács Bence András
Published: April 2022

A futball világában az egyik legkiemeltebb figyelem kétséget kizáróan az átigazolási piacot övezi. A játékjogok piacán a legeredményesebb labdarúgók szerződtetése érdekében a hatalmas költségvetésekkel rendelkező legnagyobb európai klubok versengenek. Nem ritka, hogy egy-egy játékos szerződtetése több tízmillió eurós kiadással terheli a gazdálkodó klubokat, ezzel komolyan befolyásolva az üzleti eredményüket. Az igazolások kiadás jellege ellenére azonban nem ritka, hogy adott sportszervezet értéke megemelkedik, melyre a legjobb értékmérő a tőzsdén jegyzett futball vállalatok értékelése. Kutatásomban ezen futball vállalatok átigazolások hatására bekövetkező piaci értékváltozása kerül bemutatásra a Juventus ès a BVB Dortmund példáján keresztül. Eredményeim alapján megállapítható, hogy az átigazolási időszakok következtében, amennyiben a klubok a piac által sikeresnek ítélt átigazolási politikát folytatnak, az a transzfer egyenleg eredményétől függetlenül pozitívan hat a vállalat piaci értékére, tehát tőzsdei árfolyamára. Mindkét vizsgált vállalat esetében érezhető volt továbbá a koronavírus hatása 2020 nyári átigazolási időszakában, ahol mindkét klub értékelése jelentősen csökkent valószínűsíthetően, a pandémia okozta bevételkieséseknek köszönhetően. Megállapítható továbbá, hogy a pandémia utáni időszakban a klubok kevésbé aktív átigazolási tevékenységet végeztek.
Sportfogyasztás, rajongói elköteleződés, sportstatisztika – Posztspecifikus passzolási jellemzők a labdarúgásban
Authors: Ráthonyi Gergely , Marton Szabolcs
Published: April 2022

A digitalizáció és technológia robbanásszerű fejlődése jelentős változásokat eredményezett a labdarúgásban. A különféle szenzorok és egyéb adatgyűjtések révén rendelkezésre álló növekvő adatmennyiség következtében, adatcentrikus, analitikus és statisztika orientált gondolkodás térnyerését figyelhetjük meg a labdarúgásban, melyek a rajongók, szurkolók számára is érdekességként szolgálnak. A digitalizáció szoros kapcsolatban van a sportfogyasztással is, ezért az elmúlt években jelentős változást figyelhettünk meg ezen a területen. A pandémia időszaka a digitális transzformáció sebességét a sportiparban még inkább felerősítette. A sportszervezetek és rajongóik számára az egyik legfontosabb tartalom, mely a fogyasztói élményt fokozza a mélyreható sportstatisztika és –elemzések. Tanulmányunkban a labdarúgásban leggyakrabban előforduló teljesítmény indikátort, a passzolást vizsgáltuk. Célunk volt, hogy részletesen vizsgáljuk a pozícióspecifikus passzolási jellemzőket ezért az általánostól eltérő passzolási tulajdonságokat is vizsgáltunk a kutatásunk során. Az elemzésünk mintájául a legnívósabb európai bajnokságot választottuk a Premier League-et, mely bajnokság a legmagasabb UEFA koefficienssel rendelkezik. A bajnokság 2019/2020-as szezonjának három forduló (30-32. forduló) számunkra elérhető mérkőzéseit rögzítettük és elemeztük ki a passzok szempontjából. szignifikáns különbség mutatkozott a védekező és a támadást építő játékosok átlagos mérkőzésenkénti passz számai között (t=7,988, p<0,05). A mérkőzésenként megkísérelt átadás számában és a passz pontosságában is egy fokozatos csökkenés tapasztalható a középső posztok vizsgálatában, amennyiben a pálya mélységében vizsgáljuk a posztokat. Mind a passz pontosság, mind az átlagos passz szám esetében a csökkenő rangsor megfelel a pozíciók elhelyezkedésének a pályán (a sorrend: 1, középső védő 2, védekező középpályás 3, belső középpályás 4, támadó középpályás 5, csatár). A passzok számára vetített helyzet érték mutatóban a támadó pozíciók eredményesebben teljesítettek, mint a védekező posztok. A támadó pozíciók közül is kiemelkednek a szélső posztok, ahol a passz számra vetített kialakított helyzet érték esetében a teljes vizsgálat 23,3%-át teljesítette és a kialakított helyzet érték mutatók összegének a 14%-át ezen posztok szolgáltatták. Összeségében tanulmányunk rámutat a posztspecifikus passzolási jellemzőkre és ezek tudatában kijelenthetjük, hogy a játékosok passzolási teljesítményének összehasonlítás akkor releváns, ha a játékosok azonos vagy rokon pozíciókban szerepelnek.
Amatőr és hobbi e-sportolók fizikai aktivitásának vizsgálata
Authors: Sánta János
Published: April 2022

A számítógépek és az internet elterjedésével az e-sport egy jelentős piaccal és gazdasági potenciállal bíró, rendkívül gyorsan és dinamikus fejlődő ágazat lett. A jelentőségét jelzi, hogy mára a növekedése egyes hagyományos sportokat vagy más iparágakat is megelőz. Az e-sportolók versenyzés és edzés közben is ülő tevékenységet végeznek a számítógép előtt, így az egészségüket meghatározza, hogy mellette mennyi fizikai aktivitást végeznek. Jelen kutatás elsődleges célja a különböző szintet képviselő e-sportolók fizikai aktivitásának vizsgálata. E mellett fontosnak tartottam megvizsgálni, hogy a megkérdezett játékosok milyen játékokkal versenyeznek, mennyi időt fordítanak játékra és milyen módon fejlesztik magukat. Online kérdőíves felmérést végeztem a Debreceni Egyetem által szervezett University Electronic Games (UEG) online bajnokságokban. A vizsgálatban résztvevők teljes mértékben megfeleltek a szempontjaimnak, hiszen a többségük amatőr vagy hobbi e-sportoló, így válaszaikból releváns adatokat kaptam. A résztvevők válaszai alapján általánosságban elmondható, hogy egészségjavító fizikai aktivitást végeznek. Azonban nem szabad elfelejteni, hogy nem csak az e-sport népszerűségének növekedése, de a társadalom fokozódó digitalizációja is hozzájárul a mozgásszegény életmód növekedéséhez. A jövőben fontos lenne a játékosok edzés formájának megváltoztatása, amely eddig túlnyomórészt digitális videojáték képességeik fejlesztése volt. A fizikai aktivitás és más egészséggel kapcsolatos viselkedésmódokat kell integrálni a játékosok – e-sportolók edzési rutinjaiba, hogy az e-sportolás mellett a sportolás is természetes időtöltés legyen.
A duális képzés bevezetésének nemzetközi tapasztalatai néhány ország példáján keresztül
Authors: Toth Katalin
Published: April 2022

Magyarországon 2015-ben bevezetésre került a duális képzés.  A duális képzés a munkaerőpiac igényeire adott válasz, mely bevezetése óta egyre népszerűbb. A duális képzés nemzetközi szinten is egyre jelentősebb szerepet tölt be a felsőoktatásban, segítve az oktatás, az átadott tudásanyag modernizálását és előmozdítva a vállalatok és az egyetemek kapcsolatának erősödését. A cikk célja, hogy bemutassa a duális képzés rendszerét és az eltelt időszakban összegyűjtött nemzetközi tapasztalatokat. a témában fellelhető szakirodalomra támaszkodva.
Turisztikai ellátási láncok összehasonlítása belföldi és külföldi utazások esetében
Authors: Hadházi Viktória
Published: April 2022

Az utazni vágyók minden igényét a lehető legmagasabb színvonalon kívánja kiszolgálni az utazásszervező tevékenység. Az utazások tervezéséhez és szervezéséhez kapcsolódó élmények szinte ugyanolyan fontosak, mint maga a nyaralás vagy kirándulás. Tanulmányomban összehasonlítom a belföldi és a külföldi utazások jellemzőit a fogyasztók válaszai alapján. A következő szempontok szerint történt az elemzés: utazások szervezése, az előkészületekre szánt idő, a foglalás menete, a kijelölt úticélba való eljutás, a szálláshely kiválasztása vagy az időtartama. Ugyanakkor a turisztikai szolgáltatókkal válik teljessé a lánc, akiknek együttműködése kulcsfontosságú az utazók igényeinek kielégítése tekintetében, mindannyiuk közös érdeke, hogy elégedett legyen a vendég amikor hazatér utazásáról.
Detecting Anomalies in Daily Activity Routines of Older Persons in Single Resident Smart Homes: Proof-of-Concept Study
Authors: Shahid Zahraa Khais , Saguna Saguna , Åhlund Christer
Published: April 2022

Background

One of the main challenges of health monitoring systems is the support of older persons in living independently in their homes and with relatives. Smart homes equipped with internet of things devices can allow older persons to live longer in their homes. Previous surveys used to identify sensor-based data sets in human activity recognition systems have been limited by the use of public data set characteristics, data collected in a controlled environment, and a limited number of older participants.

Objective

The objective of our study is to build a model that can learn the daily routines of older persons, detect deviations in daily living behavior, and notify these anomalies in near real-time to relatives.

Methods

We extracted features from large-scale sensor data by calculating the time duration and frequency of visits. Anomalies were detected using a parametric statistical approach, unusually short or long durations being detected by estimating the mean (μ) and standard deviation (σ) over hourly time windows (80 to 355 days) for different apartments. The confidence level is at least 75% of the tested values within two (σ) from the mean. An anomaly was triggered where the actual duration was outside the limits of 2 standard deviations (μ−2σ, μ+2σ), activity nonoccurrence, or absence of activity.

Results

The patterns detected from sensor data matched the routines self-reported by users. Our system observed approximately 1000 meals and bathroom activities and notifications sent to 9 apartments between July and August 2020. A service evaluation of received notifications showed a positive user experience, an average score of 4 being received on a 1 to 5 Likert-like scale. One was poor, two fair, three good, four very good, and five excellent. Our approach considered more than 75% of the observed meal activities were normal. This figure, in reality, was 93%, normal observed meal activities of all participants falling within 2 standard deviations of the mean.

Conclusions

In this research, we developed, implemented, and evaluated a real-time monitoring system of older participants in an uncontrolled environment, with off-the-shelf sensors and internet of things devices being used in the homes of older persons. We also developed an SMS-based notification service and conducted user evaluations. This service acts as an extension of the health/social care services operated by the municipality of Skellefteå provided to older persons and relatives.
Helping Children to Participate in Human Papillomavirus–Related Discussions: Mixed Methods Study of Multimedia Messages
Authors: Occa Aurora , Stahl Hayley M , Julien-Bell Sarah
Published: April 2022

Background

Human papillomavirus (HPV) can cause several types of cancers and genital warts. A vaccine is available to prevent HPV infections, and several efforts have been made to increase HPV education and, eventually, vaccination. Although previous studies have focused on the development of messages to educate children about HPV and the existence of the HPV vaccine, limited research is available on how to help children better communicate with their parents and health care professionals about the HPV vaccination. In addition, limited research is available on the target audience of this study (Italian children).

Objective

This manuscript describes a study assessing the feasibility of using an evidence-based animated video and a web-based game to help children (aged 11-12 years) participate in discussions about their health—in particular when such conversations center around the HPV vaccination—and improve several HPV-related outcomes. The study also compares the effects of these 2 educational multimedia materials on children’s knowledge and perceptions of HPV prevention.

Methods

A mixed methods approach consisting of focus group discussions and an experiment with children (N=35) was used to understand children’s experiences with, and perceptions of, the animated video and the game and to measure possible improvements resulting from their interaction with these materials.

Results

Both the animated video and a web-based game increased children’s knowledge and positive perceptions about HPV and HPV vaccination. Any single message was not more effective than the others. The children discussed aspects of the features and characters they liked and those that need improvements.

Conclusions

This study shows that both materials were effective for improving children’s education about the HPV vaccine and for helping them to feel more comfortable and willing to communicate with their parents and health care professionals about their health. Several elements emerged that will allow further improvements in the design and development of the messages used in this study as well as the creation of future campaigns.