bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of COVID-19 Research: A Study on Predicting Influential Scholarly Documents and Utilizing a Domain-Independent Knowledge Graph
Authors: Gollam Rabby , Jennifer D'Souza , Allard Oelen , Lucie Dvorackova , Vojtěch Svátek , Sören Auer
Published: May 2023

Multiple studies have investigated bibliometric features and uncategorized scholarly documents for the influential scholarly document prediction task. In this paper, we describe our work that attempts to go beyond bibliometric metadata to predict influential scholarly documents. Furthermore, this work also examines the influential scholarly document prediction task over categorized scholarly documents. We also introduce a new approach to enhance the document representation method with domain independent knowledge graph to find the influential scholarly document using categorized scholarly content. As the input collection, we use the WHO corpus with scholarly documents on the theme of COVID-19. This study examines different document representation methods for machine learning, including TF-IDF, BOW, and embedding-based language models (BERT). The TF-IDF document representation method works better than others. From various machine learning methods tested, logistic regression outperformed the other for scholarly document category classification, and the random forest algorithm obtained the best results for influential scholarly document prediction, with the help of a domain-independent knowledge graph, specifically DBpedia, to enhance the document representation method for predicting influential scholarly documents with categorical scholarly content. In this case, our study combines state-of-the-art machine learning methods with the BOW document representation method. We also enhance the BOW document representation with the direct type (rdf type) and unqualified relation from DBpedia. From this experiment, we did not find any impact of the enhanced document representation for the scholarly document category classification. We found an effect in the influential scholarly document prediction with categorical data.
Molecular mapping of two novel frost resistance genes in common wheat by 660k SNP array
Authors: Lei Chao , Li Mingzheng , Cheng Zhaopeng , He Wei , Liu Bin , Liu Shuqing , Li Xuejun , Xie Yanzhou
Published: May 2023

Low temperature freezing injury has always been one of the natural factors leading to serious yield reduction of wheat. How to improve the frost resistance of wheat has always been the focus of breeders and geneticists. However, the genetic improvement of wheat frost resistance has been slow, mainly due to the fact that frost resistance is a complex quantitative trait, and field phenotypic identification is relatively difficult. Therefore, the discovery of wheat frost resistance genes and the mapping and cloning of frost resistance genes not only provide a theoretical basis for the genetic improvement of wheat frost resistance, but also help to analyze the molecular mechanism of wheat frost resistance. In this study, the wheat line H261 and its EMS mutants LF2099 and XiNong 239 were used as materials. Frost-resistance / non frost-resistance trait segregation was found in the F2 generation of the mutant LF2099 and XiNong 239, and the separation ratio was 15:1. Genetic analysis showed that the frost resistance of wheat was controlled by two dominant overlapping genes, temporarily named Fr-3 and Fr-4. BSA combined with SNP array was used to locate the frost resistance gene. Fr-3 was located between SSR marker BU100519 and KASP marker AX-94843669. The genetic distance between markers was 1.32 cM, and the corresponding physical interval on Chinese Spring 2B chromosome was 5.41 Mb, including 67 genes with functional annotation. Fr-4 was located between the KASP marker AX-94657955 and the SSR marker LC-23. The genetic distance between the markers was 1.79 cM, and the corresponding physical interval on the Chinese Spring 2D chromosome was 2.35 Mb, containing 66 functional annotation genes. Compared with previous studies, Fr-3 and Fr-4 were two new frost resistance genes, which laid the foundation for the fine mapping and cloning of Fr-3 and Fr-4.
Towards smart scanning probe lithography: A framework accelerating nano-fabrication process with in-situ characterization via machine learning
Authors: Zhang Zhen , Liu Yijie , Li Xuexuan , Pei Ben , Ge Lin , Xiong Zhuo
Published: May 2023

Scanning probe lithography (SPL) is a promising technology to fabricate high-resolution, customized and cost-effective features at the nanoscale. However, the quality of nano-fabrication, particularly the critical dimension, is significantly influenced by various SPL fabrication techniques and their corresponding process parameters. Meanwhile, the identification and measurement of nano-fabrication features are very time-consuming and subjective. To tackle these challenges, we propose a novel framework for process parameter optimization and feature segmentation of SPL via machine learning (ML). Different from traditional SPL techniques that rely on manual labeling-based experimental methods, the proposed framework intelligently extracts reliable and global information for statistical analysis to fine-tune and optimize process parameters. Based on the proposed framework, we realized the processing of smaller critical dimensions through the optimization of process parameters, and performed direct-write nano-lithography on a large scale. Furthermore, data-driven feature extraction and analysis could potentially provide guidance for other characterization methods and fabrication quality optimization.
Increasing grain selenium concentration via genetic and agronomic innovations.
Authors: Daud Mohammed Feizel Bin , Bilsborrow Paul , Rempelos Leonidas , Cakmak Ismail , Leifert Carlo
Published: May 2023

Aims
To evaluate the potential to enhance grain Selenium (Se) concentration in wheat through agronomic innovation practices and exploitation of existing genetic variation.
Methods
Grain samples from field experiments carried out as part of the EU projects Nitrogen Use Efficiency (NUE-CROPS), Healthy Minor Cereals (HMC) and Quality Low Input Food (QLIF) were analysed to identify the effects of wheat species/variety, fertiliser type and crop protection regime on grain yield, grain protein and selenium concentrations.
Results
Fertiliser type significantly affected grain Se concentration. In the NUE-CROPS and QLIF trials the use of farm-yard manure (FYM) resulted in significantly higher grain Se concentration when compared with mineral fertiliser applied at the same N input level. Similarly, in the HMC trial, FYM and cattle slurry resulted in a significantly higher grain Se concentration compared with biogas digestate and mineral fertiliser. In the QLIF trials, organic crop protection resulted in significantly higher grain Se concentration when compared with conventional crop protection. The NUE-CROPS and HMC trials detected significant differences between varieties of both common wheat (Triticum aestivum) and spelt (T. spelta). Correlation analyses across the trials identified a negative correlation between yield and grain Se concentration for spelt and positive correlation between plant height and Se concentration for both species.
Conclusions
Higher Se concentrations in the taller spelt varieties suggest that there is considerable potential to breed/select for high grain Se by exploiting traits/genetic variation present in older, traditional wheat species (e.g. spelt).
BongHope: An Annotated Corpus for Bengali Hope Speech Detection
Authors: Nath Tanusree , Singh Vivek Kumar , Gupta Vedika
Published: May 2023

The rapid growth of social media usage has resulted in huge volume of online content, which includes instances of spread of negativity through the influence of hateful speeches as well as innumerable instances of social media providing supportive and encouraging content, which is often referred to as hope speech. Hope Speech has been recently defined in the context of online content as a textual content that promotes peace and reflects a hopeful attitude. Recently some research has been conducted on automatic detection of hope speech in different languages, including English, Tamil, Malayalam, Spanish and Kannada. However, to the best of our knowledge, there is no work on hope speech research in Bengali language text. Bengali is a language with more than 210 million speakers[2] and a lot of content in various social media platforms. Therefore, it is important to develop appropriate computational methods for automatic detection of text in Bengali as Hope and Non-Hope speech. One possible reason for lack of hope speech research in Bengali language is perhaps the non-availability of suitable dataset/ corpus for the purpose. This work, therefore, attempts to bridge this research gap by presenting a suitably curated and annotated high quality dataset comprising of tweets in Bengali language for the purpose of hope speech research. Several state-of-the-art computational models are applied on the created dataset and the results obtained confirm the suitability of the dataset for hope speech research.
[2] https://www.britannica.com/topic/Bengali-language
Effects of Osmolality of Rice Sports Drinks on Sports Performance
Authors: Peepathum Prasit , Mitranun Witid , Jirarattanarangsri Wachira , Surawang Suthat , Loakuldilok Thunnop , Koonrungsesomboon Nut , Braspaiboon Sukan , Osiriphun Sukhuntha
Published: May 2023

Sports drinks are developed to improve performance and prevent or treat dehydration, heatstroke, and muscle cramps. The osmolality and pH of sports drinks affect fluid retention and restoration of fluids lost due to dehydration. This study aimed to compare the effects of a new rice-based sports drink (hypertonic, D group) on performance and related sports physiology with that of four other drinks (control, group A; isotonic, group B; hypotonic, group C; commercial, group E), and to develop a range of rice-based sports drinks. The pH, total titratable acidity, nutritional value, and osmolality of the five drinks were measured in vitro. The association between the osmolality of sports drinks and performance was determined in 20 football players. Tests were performed using a cycle ergometer, after which the blood samples were obtained. Blood glucose levels were significantly higher in groups B, C, D, and E than in the control group (p < 0.05). Blood lactate levels were significantly lower in group D than in the other groups after exercise (p < 0.05). The osmolality of the hypertonic rice sports drink was 402.34 mOsmol/kg, indicating that this drink is expected to enhance endurance performance. Consumption of hypotonic rice drinks affects endurance performance in a similar manner to isotonic drinks and may be more beneficial to endurance performance relative to water and hypotonic drinks that lack sodium. Rice hypertonic drinks can even improve performance by drawing fluid from the circulation into the gut. Understanding osmolality and sports performance values can be useful in commercial beverage production and sports nutrition.
Identification of Quantitative Trait Loci for Drought Tolerance in Bukoba/ Kijivu Andean Mapping Population of Common Bean
Authors: Hamabwe Swivia M , Otieno Nicholas , Soler-Garzón Alvaro , Miklas Phillip , Parker Travis , Kramer David M , Chattopadhyay Abhijnan , Cheelo Pride , Kuwabo Kuwabo , kamfwa kelvin
Published: May 2023

Drought is a major production constraint of common bean (Phaseolus vulgaris L.) worldwide. The objective of this study was to identify the Quantitative Trait Loci (QTL) for drought tolerance in an Andean population of Recombinant Inbred Lines (RILs). A total of 155 F5:7 RILs derived from a cross between Kijivu (drought tolerant) and Bukoba (drought susceptible) were evaluated for drought tolerance in field and pot experiments. Four field experiments were conducted at three locations, including the University of Zambia Research Farm, Golden Valley Agricultural Research Farm, and Kabwe Zambia Agricultural Research Institute Farm, in 2021 and 2022. All field trials were conducted in the dry season under irrigation. The 155 RILs were genotyped with 11,292 SNPs, and composite interval mapping was conducted to identify QTL for drought tolerance. Seed yield for Kijivu under drought stress was consistently higher than for Bukoba across all four field trials. A total of 71 QTL were identified for morphological, agronomic, and physiological traits under drought stress and non-stress conditions. However, the majority of these QTL were specific to drought stress. QTL “hotspots” for drought tolerance were identified on chromosomes Pv06, Pv07, and Pv10. Extensive co-localizations for agronomic and morpho-physiological traits under drought stress were observed at the three drought-tolerance QTL hotspots. Additionally, these three QTL hotspots overlapped with previously identified QTL for drought tolerance, while several other identified QTL are novel. The three identified QTL hotspots could be used in future marker-assisted selection for drought tolerance in common bean.
Low ACADM expression predicts poor prognosis and suppressive tumor microenvironment in clear cell renal cell carcinoma
Authors: Zhou Libin , Yin Min , Guo Fei , Yu Zefeng , Weng Guobin , Long Huimin
Published: May 2023

Clear cell renal cell carcinoma (ccRCC) represents a highly frequent renal cancer subtype. However, medium-chain acyl-CoA dehydrogenase (ACADM) encodes an important enzyme responsible for fatty acid β-oxidation (FAO) and its association with prognosis and immunity in cancers has rarely been reported. Therefore, the present work focused on exploring ACADM’s expression and role among ccRCC cases. We used multiple public databases and showed the hypo levels of ACADM protein and mRNA within ccRCC, which was attributed to the hypermethylation of the ACADM promoter region. Additionally, we found that ACADM down-regulation showed remarkable relation to advanced stage, high histological grade, as well as dismal prognostic outcome. As suggested by Kaplan-Meier curve analysis, cases showing low ACADM levels displayed shorter overall survival (OS) as well as disease-free survival (DFS). Moreover, according to univariate/multivariate Cox regression, ACADM-mRNA independently predicted prognosis of ccRCC. In addition, this work conducted immunohistochemistry for validating ACADM protein expression and its prognostic role in ccRCC samples. KEGG and GO analyses revealed significantly enriched genes related to ACADM expression during fatty acid metabolism. We also found that the low ACADM expression was closely related to immunosuppressive cells and, ultimately, poor response to immunotherapies. In conclusion, our results confirmed that downregulated ACADM predicted a poor prognosis for ccRCC and a poor response to immunotherapy. Our results provide important data for developing immunotherapy for ccRCC.
A Novel Strategy for Preparation of Solvent-Free High-Solid Content Water-Based Polyurethane
Authors: Fan Haojun , Yao Aisong , Li Heng , Luo Haihang , Zhao Jianming , Xiang Jun , Chen Yi
Published: May 2023

Eethylenediamine (EDA), isophorone diamine (IPDA), diethylenetriamine (DETA), N- β- (aminoethyl)- γ- aminopropylmethyl dimethoxysilane (KH602) and polyether amine (D-230) were used as post chain extenders, a series of solvent-free high-solid content water-based polyurethanes (WPU) were prepared. The reactivity of different post chain extenders and the effects of different R values (mole ratio of –NCO/-OH) on solid content as well as the effects of chain extension degree on properties of WPU were investigated in detail. Among of water, small molecule diamine and diol, diamine with higher activity is preferred to water to complete the post chain extension reaction and improves the mechanical properties of WPU. When the R value is higher than 1.7 and the post chain extension degree is controlled at 70%, the viscosity of the solvent-free prepolymer is small enough to be emulsified, and the as-prepared WPUs show more excellent thermodynamic properties. In comparison, the cyclic chain extender such as IPDA can improve the mechanical properties and heat resistance of WPU, crosslinking type chain extenders involving DETA and KH602 can improve the heat resistance and anti-sticking of WPU coating. Whilst the WPU prepared by the chain extender containing flexible space, such as D-230, has a very low modulus and is suitable for preparing soft–type WPU.
Electromagnetic field-assisted low-temperature ammonia synthesis
Authors: Zhang Bin , Zhang Bao Shun , Wang Yuting , Zhang Na , Zhu Jiewei , Ji Wangyang , Chen Fanpeng , Chen Xing , Yu Yifu
Published: May 2023

Conventional ammonia synthesis (Haber-Bosch method) requires high temperature and high pressure, leading to extensive energy consumption and carbon emissions. Herein, an electromagnetic field (EMF)-assisted technique is developed for ammonia synthesis under mild conditions. With the assistance of EMF, commercial Fe-based catalysts exhibit obvious enhancement in ammonia yield (5 times) and energy efficiency (2.7 times) at 200°C and 1 MPa, originating from the effective activation of the N≡N bond.
Synthesis of allylamines from Baylis-Hillman acetates using DBU under solvent free condition
Authors: Khom Sonam Tashi , Saikia Pranjit , Muzaddadi Ijaz Ullah , Murugan Arumugam , Yadav Nagendra Nath Nath
Published: May 2023

A simple, new and solvent free route to the regioselective and stereoselective synthesis of (E)- and (Z)- allylamines has been achieved by the reaction of Baylis-Hillman acetates with various nitrogen nucleophiles in the presence of 1,8-diazabicyclo(5.4.0)undec-7-ene (DBU). This method requires very short reaction time and accomplished by SN2ʹ nucleophilic substitution pathway.
Orthodontic Patients and the Information Found on the Web: A Cross-sectional Study
Authors: Crispino Roberta , Mannocci Alice , Dilena Irene Alfonsa , Sides Jackson , Forchini Federico , Alherawi Wael Mohammad Asif , Frazier-Bowers Sylvia A. , Grippaudo Cristina
Published: May 2023

Background We sought to understand the relevance of online information for prospective orthodontic patients and to investigate the effects of digital research on patients’ decision-making process. We speculate that generational differences exist between digital natives and digital immigrants.Materials and methods An anonymous questionnaire was developed to investigate patients’ orthodontic-themed Web searches as well as the effects digital material had on their decision-making process. Before submitting the newly designed survey to patients, it was validated in a pilot study. Univariate analysis was applied to analyze the relationship between the demographic characteristics of respondents and their answers on the use of digital research for the decision-making process.Results 64.6% of the study population searched the Web for orthodontic information prior to their visit. Google was the most used platform regardless of patients’ age. The perceived reliability of online sources varied significantly with age. Men displayed more trusting behavior towards their doctor than women. Prospective patients’ satisfaction with affected patients’ decision-making processes, and the perceived reliability of online sources of information had repercussions on the doctor-patient relationship.Conclusions Orthodontists should be aware that the majority of patients use the Internet as a source for orthodontic information, and that patients who are digital immigrants are more prone to trust the information found online. Patients who perceive the information found on the Web as either useful or reliable don’t easily discard it, even if it is inconsistent with the orthodontist’s opinion.
Temperature extremes of 2022 reduced carbon uptake by forests in Europe
Authors: Peters Wouter , Woude Auke van der , Luijkx Ingrid , Joetzjer Emilie , Lafont Sébastien , Loubet Benjamin , Herig-Coimbra Pedro-Henrique , Loustau Denis , Koren Gerbrand , Ciais Philippe , Ramonet Michel , Xu Yidi , Bastos Ana , Sitch Stephen , Kneuer Tobias , Kubistin Dagmar , De Kok Remco , Botía Santiago
Published: May 2023

The year 2022 saw record breaking temperatures in Europe during both summer and fall. Close to 30% of the European continent was under severe summer drought with a similarly large area affected (3.0 million km2) as during the recent 2018 drought, but now located in central and southeastern Europe. Multiple sets of observations suggest a reduction of net ecosystem carbon exchange in summer (57-62 TgC) over this area, and specific sites in France even showed a widespread summertime carbon release by forests, as well as wildfires. A warm fall with prolonged carbon uptake offered only partial compensation (up to 32%) for the carbon uptake lost due to drought. This severity of this second drought event in 5 years suggests these impacts to no longer be exceptional, and important to factor into Europe's developing plans for net-zero greenhouse gas emissions that rely on carbon sequestration by forests.
In vitro evaluation and characterization of cisplatin loaded nanofibers for local chemotherapy
Authors: Mendoza Carlos Miguel López , Figueroa Yolanda Terán , Sánchez Mariana Gutiérrez , Ortega María Mónica Castillo , Fuentes Nayeli Rodríguez , Alcántara Luz Eugenia
Published: May 2023

Cancer is a disease that affects the quality of life of the patients that are treated with Cisplatin (CDDP), which is needed for adjuvant therapy, however it leads to many secondary and adverse effects. In this study, we manufactured and characterized poly- (lactic acid) (PLA) non-woven fibers charged with Cisplatin (CDDP) by electrospinning technique to evaluate their cytotoxicity in in vitro assays on HeLa cells (Cervical Carcinoma Cell Line). PLA – CDDP solutions with increasing concentrations of CDDP (0.5, 1 and 2 % w/w) were used in a TL-01 electrospinning equipment with the same system parameters. We analyzed the chemical, thermal and morphological characteristics of PLA and PLA – CDDP fiber mats. Furthermore, hydrolytic degradation, haemolysis and toxicity in HeLa cells were evaluated. By adding the CDDP to the fibers, the degradation, glass transition and melting temperatures were modified; the 3 µm fiber diameter of pristine PLA fibers was decreased in half the size and the degradation time was extended over 5 months. However, the hemocompatibility of the material with and without CDDP was mantained, while cytotoxicity in HeLa cells increased in the three concentrations of fiber mats of PLA – CDDP compared to the intravenous drug at 24 h (P = ). We concluded that the fiber mats PLA – CDDP could be used for localized treatment in the adjuvant treatment when resection panels are expose after a surgical extirpation of solid tumors
Glutamate production from aerial nitrogen using nitrogen-fixing bacterium Klebsiella oxytoca
Authors: Nishiyama Makoto , Yoshidome Daisuke , Hidaka Makoto , Miyanaga Toka , Ito Yusuke , Kosono Saori
Published: May 2023

Glutamate is an essential biological compound produced for various practical uses. However, the current glutamate production process requires a large amount of ammonium produced through the most energy-consuming and CO2-emitting Haber–Bosch process; hence, the development of bioeconomical glutamate-producing processes has long been awaited. This study demonstrates a novel strategy for glutamate production from aerial nitrogen using the nitrogen-fixing bacterium Klebsiella oxytoca. Carbon sources were first investigated to enhance the nitrogenase activity of K. oxytoca, and it was found that the simultaneous supply of glucose and citrate was effective. K. oxytoca was genetically engineered to increase citrate uptake under glucose-citrate-coexisting conditions and the supply of 2-oxoglutarate, a direct precursor of glutamate synthesis. As a result, extracellular production of glutamate over 1 g L-1 of culture from aerial nitrogen was achieved. This strategy offers a sustainable and eco-friendly manufacturing process to produce various nitrogen-containing compounds using aerial nitrogen.
LncRNA THUMPD3-AS1 promotes invasion and EMT in gastric cancer by regulating the miR-1297/BCAT1 pathway
Authors: Zhang Zaibo , Li Yong , Fan Liqiao , Wang Bingyu , Liu Wenbo , Cui Jiaxiang , Tan Bibo
Published: May 2023

Objective Long noncoding RNAs (lncRNAs) are significant regulators in gastric cancer（GC）; However, studies of their mechanisms of action are needed to determine their clinical value. In this study, we investigated the effects and mechanism of action of THUMPD3-AS1 in GC.
Methods Candidate lncRNAs and mRNAs were getted from The Cancer Genome Atlas, revealing the differential expression and prognostic significance of THUMPD3-AS1-BCAT1 in GC. qRT-PCR was performed to detect THUMPD3-AS1 levels in GC samples and cell lines. CCK8, scratch wound healing, and Transwell assays as well as experiments in vivo were conducted to evaluate the function of THUMPD3-AS1 in GC. Related genes were analysed to detect interactions between THUMPD3-AS1, BCAT1, and miR-1297.
Results THUMPD3-AS1 levels were significantly elevated in GC and were positively correlated with poor prognosis. Functionally, THUMPD3-AS1 promoted GC cell proliferation, migration, invasion, and epithelial–mesenchymal transition (EMT) and induced tumour growth in vivo. THUMPD3-AS1 regulated BCAT1 by competitively binding to miR-1297; further analyses revealed that both THUMPD3-AS1 and miR-1297 can interact with BCAT1.
Conclusions These findings demonstrate that THUMPD3-AS1 promotes GC cell invasion and EMT via the miR-1297/BCAT1 pathway, suggesting that THUMPD3-AS1 is a novel biomarker and therapeutic target for GC.
Yielding and post-yielding behavior of FDM parts under compression stress
Authors: Scipioni Silvia Ilaria , Lambiase Francesco
Published: May 2023

The present study investigates the compression behavior of components made by material extrusion, also known as fused filament fabrication (FFF) or fused deposition modeling (FDM). An experimental plan was conducted by adopting a high-density fulfillment and varying the material flow. Additional tests were performed by thermomechanical compaction to produce full-density samples. Compression tests were performed at various strain rates ranging between 5 10− 4 to 5 10− 1 s− 1. Yielding and post-yielding behaviors were analyzed. Morphological analysis was carried out to determine the mesostructural features (interlayer neck and void sizes) and how they behave during the compression test. The results indicated that the principal dimension of the voids ranged between 65 µm and 170 µm depending on the adopted value of the extrusion multiplier. On the other hand, thermomechanical compaction enabled the restriction of the voids of printed samples to 10 µm. The cross-sectioning of samples at different strains indicated the formation of shear banding strain localization. In addition, printed samples behaved like porous media during the compression tests and showed different characteristic regions with different voids dimensions. The samples printed at the higher material extrusion showed similar behavior to compacted samples. Post-yielding analysis indicated that strain softening observed on compacted samples was more severe as compared to that observed on printed samples. this behavior is dramatically reduced by decreasing the extrusion multiplier.
AI based Recommendation System for smart investment decisions to maximize Fuzzy ROI
Authors: D Maria Manuel Vianny , Vaddadi Srinivas Aditya , C Karthikeyan , Shahid Mohammad , Dhanapal R. , M Ravichand
Published: May 2023

In the current training, Artificial Neural Network (ANN) is utilized, which tuned by Particle Swarm Optimization (PSO) to the challenge of predicting for finance applications. Several researches have shown that ANN-based strategies are trustworthy ways to estimate LSM. Most ANN training methods, however, struggle with serious issues including poor learning rates and getting stuck in indigenous smallest amount. Optimization algorithms (OA) like PSO container increase ANN presentation. PSO prototypical applications to ANN exercise not engaged in success planning to determine network design or relevant elements. Thus, the current work concentrated scheduled the request of a mixture ANN prototypical to the forecast based on fuzzy. For the ANN and PSO-ANN network models, a huge amount of statistics (a record with 168970 preparation records and 42243 challenging records) was collected after the Finance application. This data was used to make exercise and challenging datasets. All of the PSO algorithm variables (including the system limitation and system loads) remained tuned to provide maximized ROI. The projected outcomes (e.g., from ANN, PSO-ANN) aimed at together records (e.g., training and testing) of the models were calculated by one numerical catalogs, namely, Root-Mean-Squared Error (RMSE). As a consequence, together replicas displayed worthy presentation; nevertheless, the hybrid ANN model might outperform ANN in terms of performance, as determined by the ranking mechanism that was created. For the ANN and hybrid ANN replicas, it container be derived that the PSO-ANN prototypical demonstrated more dependability in predicting compared to the ANN.
Haploidentical transplant with posttransplant cyclophosphamide vs matched related and unrelated donor transplant in acute myeloid leukemia and myelodysplastic neoplasm
Authors: Rieger Max , Stolz Sebastian , Müller Antonia , schwotzer rahel , Nair Gayathri , Schneidawind Dominik , Manz Markus , Schanz Urs
Published: May 2023

Hematopoietic cell transplantation from haploidentical donors (haploHCT) has facilitated treatment of AML and MDS by increasing donor availability and became more feasible since the introduction of post-transplant cyclophosphamide (ptCY). In our single-center retrospective analysis including 213 patients with AML or MDS, we compare the outcome of haploHCT (n=40) with ptCY with HCT from HLA-identical MRD (n=105) and MUD (n=68). At 2 years after transplantation, overall survival (OS) after haploHCT was not significantly different (0.59; 95% confidence interval 0.44 - 0.79) compared to MRD (0.77; 0.67 - 0.88) and MUD transplantation (0.72; 0.64 - 0.82, p = 0.51). While progression-free survival (PFS) was also not significantly different (haploHCT: 0.60; 0.46 - 0.78, MRD: 0.55; 0.44 - 0.69, MUD: 0.64; 0.55 - 0.74, p = 0.64), non-relapse mortality (NRM) was significantly higher after haploHCT (0.18; 0.08 - 0.33) vs. MRD (0.029; 0.005 - 0.09) and MUD (0.06; 0.02 - 0.12, p<0.05). Higher NRM was mainly caused by a higher rate of fatal infections, while deaths related to GvHD or other non-relapse reasons were rare in all groups. As most fatal infections occurred early and were bacterial related, one potential risk factor among many was identified in the significantly longer time to neutrophil engraftment after haploHCT with a median of 16 days (interquartile range; 14.8 - 20.0) vs. 12 days (10.0 - 13.0) for MRD and 11 days (10.0 - 13.0) for MUD (p=0.01).
Solid-To-Solid Polymorphic Phase Transitions in Two Isostructural Bi(III) Complexes With 1-Phenylethyl-N-Ethylthiosemicarbazide and Halogens
Authors: Grześkiewicz Anita M. , Dutkiewicz Grzegorz , Aygun Ozlem , Ozturk Ibrahim I. , Kubicki Maciej
Published: May 2023

Two isostructural (in room temperature) complexes of Bi(III) with halogens and sulfur ligands have been investigated in terms of the solid-to-solid phase transitions indicated by temperature. Both chloride and bromide (X) complexes of the general formula (µ2-X)-(BiX2L2)2 exhibit some phase transitions between 100 and 333 K, which, apart from the numerous similarities, show significant differences, which have been noted and analyzed in detail in this paper by using different techniques, i.a., powder and single crystal diffraction or DSC. The obtained results have also been collated with those obtained for solid solutions of both complexes.
Three-dimensional CT imaging in extensor tendons using deep learning reconstruction: Optimal dose and reconstruction parameters
Authors: Tsuboi Kunihito , Kanbe Takamasa , Matsushima Hiroshi , Ohtani Yuki , Tanikawa Ken , Kaneko Masanori
Published: May 2023

The purpose of this study was to evaluate the optimal tube current and reconstruction parameters in extensor tendons 3-dimensional computed tomography (3D CT) using deep learning reconstruction, using iterative reconstruction as a reference. In phantom study, a cylindrical phantom with a 3 mm rod simulated an extensor tendon was used. The phantom images were scanned at tube current of 50, 100, 150, 200, and 250 mA. In the clinical study, nine hands in eight patients underwent CT of hand tendons. All images were reconstructed using advanced intelligent clear-IQ engine (AiCE) parameters (body, body sharp, brain CTA, and brain LCD) and adaptive iterative dose reduction three dimensional (AIDR 3D). Objective image quality for detectability of tendons was evaluated by calculated the low-contrast object specific contrast-to-noise ratio (CNRLO) in our phantom study and CNR and coefficient of variation (CV) in the clinical study, respectively. In phantom study, CNRLO (200 mA) of AiCE parameters (body, body sharp, brain CTA, and brain LCD) and AIDR 3D were 5.2, 5.3, 5.3, 5.8, and 5.0, respectively. In the clinical study, AiCE brain CTA was higher CNR and lower CV values than other reconstruction parameters. AiCE without dose reduction may be a useful strategy to further improve image quality of extensor tendons 3D CT. Our study suggests that the AiCE brain CTA is more suitable for extensor tendons 3D CT than other AiCE parameters.
Experimental study of in-medium spectral change of vector mesons at J-PARC
Authors: Aoki Kazuya , Arimizu Daichi , Ashikaga Sakiko , Chang Wen-Chen , Chujo Tatsuya , Ebata Kengo , En'yo Hideto , Esumi Shinichi , Hamagaki Hideki , Honda Ryotaro , Ichikawa Masaya , Kajikawa Shunsuke , Kanno Koki , Kimura Yuta , Kiyomichi Akio , Kondo Takehito , Kyan Shono , Lin Che-Sheng , Lin Chih-Hsun , Morino Yuhei , Murakami Hikari , Murakami Tomoki , Muto Ryotaro , Nagafusa Shunnosuke , Nakai Wataru , Nakasuga Satomi , Naruki Megumi , Nonaka Toshihiro , Noumi Hiroyuki , Ochiai Shuta , Ozawa Kyoichiro , Sakaguchi Takao , Sako Hiroyuki , Sakuma Fuminori , Sato Susumu , Sawada Shinya , Sekimoto Michiko , Shigaki Kenta , Shirotori Kotaro , Sugimura Hitoshi , Takahashi Tomonori , Takaura Yudai , Tatsumi Ryohei , Tsukui Kosuke , Wang Po-Hung , Yahiro Kanta , Yamaguchi Kanako , Yokkaichi Satoshi
Published: May 2023

Chiral symmetry and its spontaneous breaking is an essential property of the QCD vacuum and is closely related to the generation of hadron mass. J-PARC E16 experiment measures dielectron spectra in p+A collisions at 30~GeV to study the in-medium spectral change of vector mesons that signals the partial restoration of the broken symmetry. The experiment uses the primary proton beam available at the high-momentum beam line of the J-PARC hadron experimental facility.We performed three proton-beam runs intended for beamline and detector commissioning. We are preparing for the next commissioning run in 2023 and the first physics run. We present the experimental setup, some of the expected results, preparation status, and some findings in the commissioning runs.
Lie symmetry analysis, exact solutions and conservation laws to multi-component nonlinear Schrodinger equations
Authors: Bai Yushan , Liu Ya-Na , Ma Wen-Xiu
Published: May 2023

In this paper, the Lie symmetry group method is used to study the multi-component nonlinear Schr\"{o}dinger (MNLS) equations in nonlinear mathematical physics. The Lie point symmetries of MNLS equations are obtained. By applying the obtained symmetries, the symmetry reductions and some explicit solutions to the MNLS equations are constructed. In addition, we also find the conservation laws of the MNLS equations using Ibragimov's method.
Identification of m6A- and ferroptosis-related lncRNA signature for predicting immune efficacy in thymoma
Authors: Fang Hao , Li Runze , Sun Xinti
Published: May 2023

BACKGROUND: N6-methyladenosine (m6A) methylation and ferroptosis assist long non-coding RNAs (lncRNAs) to promote immune escape in thymoma (THYM). However, the predictive power of m6A and ferroptosis-associated lncRNAs in immune potency remains unknown.
METHODS: A total of 120 THYM samples with complete data were obtained from The Cancer Genome Atlas (TCGA) database as the training cohort, and half of them were randomly composed as the validation cohort, and various methods such as regression analysis and enrichment analysis were applied to screen, evaluate, etc.
RESULTS: We constructed prognosis-associated mfrlncRNA pairs after screening for lncRNAs associated with m6A regulators and ferroptosis-associated genes. According to this, the mfrlncRNA signature was founded utilizing least absolute shrinkage and selection operator (LASSO) analysis and Cox regression. We found that patients' risk score was an independent risk factor and was much better than clinical stage as an indicator. In addition, patients in the high-risk group had a poorer prognosis with higher B cells naive and Macrophages M0/M1/M2 infiltration, lower Plasma cells and T cells CD4 naive infiltration, higher immune escape potential (higher TIDE score) and higher IC50. Finally, mfrlncRNA signature contributes to risk prediction in THYM patients and prognostic improvement.
CONCLUSIONS: The mfrlncRNA signature has great prognostic value and may help to explore the relevant immune mechanisms in depth, with key implications for individualized treatment to improve the prognosis of THYM patients.
The effects of clear aligner to move mandibular first molar distally using finite element method.
Authors: Kang Fujia , Zhang Xiya , Zhang Han , Wu Yumiao , Wang Songqing , Yuan Jiamin , Hu Zhiqiang , Zhu Xianchun
Published: May 2023

Objectives To analyze the features of tooth movement with clear aligner(CA) under different starting point and attachment settings.Materials and methods A 3D finite element(FE) model was established including mandible, dentition, periodontal ligaments(PDLs), CA and horizontal rectangular attachment. The second molar was previously positioned 3.2mm distally. Three groups were created according to attachment setting: (1)no attachment, (2)attachment on the second molar, (3) attachment on the first molar. In each group, the starting point of the first molar was 0mm(SET1), 1mm(SET2), 2mm(SET3) and 3mm(SET4) to the premolar in turn. A distal moving distance of 0.2 mm was applied to the first molar.Results As the first molar got closer to the second molar, distal displacement of the first molar, mesial displacement of premolar and labial displacement of anterior teeth increased, while the mesial displacement of the second molar decreased. When the attachment was applied on the buccal surface of the first molar, the average displacement value reached the top for the first molar(6.79e− 2mm), premolar(2.72e− 2mm) and anterior teeth(2.59e− 2mm) in SET 4. The average displacement of the second molar reached the top(3.07e− 2mm) in SET1 when attachment was placed on the second molar.Conclusions The distal displacement of the first molar resulted in an opposite movement of other teeth in dentition without additional anchorage. The effect of mesial and labial movement increased except for the second molar when the first molar moved distally. The horizontal rectangular attachment placed on the first molar produced more distal movement of the first molar crown.
Not easy-peasy to diagnose: familial Mediterranean fever unaccompanied by fever as neither always Mediterranean
Authors: Arık Selen Duygu , Kayaalp Gülşah Kavrul , Guliyeva Vafa , Demirkan Fatma Gül , Tanatar Ayşe , Akgün Özlem , Çağlayan Şengül , Ulu Kadir , Coşkuner Taner , Karadağ Şerife Gül , Sözeri Betül , Ayaz Nuray Aktay
Published: May 2023

Purpose Classical attacks of familial Mediterranean fever (FMF) are often accompanied by fever, but some of the patients have attacks without fever. This study aimed to compare the characteristics of FMF patients with and without fever during their attacks and draw attention to the different clinical presentations of FMF in children.Methods Medical files of patients aged 0–18 years who were followed up with the diagnosis of FMF in two reference pediatric rheumatology centers were reviewed retrospectively. The patients were divided into two groups: Children who had had no fever in any of their attacks were assigned as group 1, and those who had fever during their attacks were classified as group 2.Results Out of 2003 patients evaluated, 191 (9.53%) patients had attacks not accompanied by fever and their median age at onset of symptoms (7.0 vs. 4.0 years, p < 0.001) and the median age at diagnosis (8.6 vs. 6.0 years, p < 0.001) were significantly higher, however group 2 had delay in diagnosis. The annual number of attacks and abdominal attacks were more common in group 2, arthritis, arthralgia, erysipelas-like rash, exercise-induced leg pain, and myalgia were more common in group 1.Conclusion The data from the assessment of children with FMF attacks not accompanied with fever were presented for the first time. Children with late age onset of FMF and dominance of musculoskeletal features may display attacks not accompanied with fever.
Validity of low-magnification narrow-band imaging in annual endoscopy screening for gastric neoplasms: A case-control study
Authors: Nagashima Ryuichi
Published: May 2023

I have previously reported the efficacy of whole stomach observation using magnifying narrow-band imaging at low magnification (LM-NBI) after routine white light imaging (WLI). LM-NBI detects lesions missed on WLI. However, the validity of annual examinations are yet to be elucidated. This historical case-control study was conducted on patients with chronic gastritis at a single institution. The patients were divided into two groups: the LM-NBI group, which include patients who underwent whole stomach observations with LM-NBI, defined as the minimal magnification required to reveal the microsurface pattern of the gastric mucosa after WLI; and the conventional endoscopy (CE) group as the control. Investigations included an index endoscopy followed by approximately five annual endoscopes. A total of 388 patients were assigned to the LM-NBI group, whereas 381 were to the CE group. Fifteen cases of gastric neoplasia were identified in the LM-NBI group, and five cases in the CE group. A hazard ratio of 2.78 (95% CE, 1.01 to 7.64) was determined using a Cox proportional-hazards model, and using Kaplan–Meier analysis (p = 0.039, by log-rank test), annual LM-NBI was superior to CE in detecting gastric neoplasia. This is the first study to report the efficacy of annual endoscopies using LM-NBI.
A Monte Carlo model of the Dingo thermal neutron imaging beamline
Authors: Jakubowski Klaudiusz , Chacon Andrew , Tran Linh T. , Garbe Ulf , Bevitt Joseph , Olsen Scott , Franklin Daniel R. , Rosenfeld Anatoly , Guatelli Susanna , Safavi-Naeini Mitra
Published: May 2023

In this study, we present a validated Geant4 Monte Carlo simulation model of the Dingo thermal neutron imaging beamline at the Australian Centre for Neutron Scattering. The model, constructed using CAD drawings of the entire beam transport path and shielding structures, is designed to precisely predict the in-beam neutron field at the position at the sample irradiation stage. The model’s performance was assessed by comparing simulation results to various experimental measurements, including planar spatial thermal neutron distribution obtained in-beam using gold foil activation and 10B4C-coated microdosimeters and the out-of-beam neutron spectra measured with Bonner spheres. The simulation results demonstrated that the predicted neutron fluence at the field’s centre is within 8.1% and 2.1% of the gold foil and 10B4C-coated microdosimeter measurements, respectively. The logarithms of the ratios of average simulated to experimental fluences in the thermal (Eth < 0.414 eV), epithermal (0.414 eV < Eepi < 11.7 keV) and fast (Efast > 11.7 keV) spectral regions were approximately -0.03 to +0.1, -0.2 to +0.15, and -0.4 to +0.2, respectively. Furthermore, the predicted thermal, epithermal and fast neutron components in-beam at the sample stage position constituted approximately 18%, 64% and 18% of the total neutron fluence.
Revisiting the influence of emulsion droplets on the distribution of the active material inside spray dried microparticles
Authors: Fleury Fernanda Esteves , Kurozawa Louise , Prata Ana Silvia
Published: May 2023

The aim of this study was to investigate how an emulsifying agent behaves during the spray drying process. For this, the evolution of droplet size during the emulsion and redispersion in matrix phases were monitored as a function of the process conditions and formulations. The emulsions were prepared using maltodextrin and modified starch (Capsul) as wall materials, and d-limonene as the active compound. The increase in surfactant concentration favored the reduction in size of the oil droplets during the emulsification, atomization, drying and redispersion of the powder processes. A correlation was observed between the size of the oil droplets in the initial and reconstituted emulsion, with the encapsulation efficiency. Reconstituted emulsions with oil droplet sizes below 1 µm, led to encapsulation efficiency above 81.53%. The results confirm that the size of oil droplets in the emulsion and the surfactant concentration directly influences the process and the stability of the microparticles.
Malnutrition- Inflammation- Atherosclerosis (MIA) syndrome associates with periodontitis in end-stage renal disease patients undergoing hemodialysis: A cross-sectional study
Authors: Mikami Risako , Mizutani Koji , Gohda Tomohito , Matsuyama Yusuke , Gotoh Hiromichi , Nakagawa Keita , Takemura Shu , Aoyama Norio , Matsuura Takanori , Kido Daisuke , Takeda Kohei , Saito Natsumi , Izumi Yuichi , Iwata Takanori
Published: May 2023

Aim Malnutrition-inflammation-atherosclerosis (MIA) syndrome is a significant risk factor for mortality in patients undergoing hemodialysis. This study aimed to investigate the association between MIA syndrome and oral health status in hemodialysis patients.Material and methods A cross-sectional study was conducted on 254 hemodialysis patients. Comprehensive medical and dental examinations were performed. Three components were included to define MIA syndrome: albumin levels, serum high-sensitivity C-reactive protein, and history of cardiovascular events as indicators of malnutrition, inflammation, and atherosclerosis, respectively. The association of MIA syndrome components with periodontitis and occlusal support was examined by multiple-ordered logistic regression analysis.Results Of 254 participants, 170 (66.9%) had at least one component of MIA syndrome. After adjusting for possible confounding factors, severe periodontitis was significantly associated with presence of more components of MIA syndrome (odds ratio [OR]: 2.40, 95% confidence interval [CI], 1.33–4.34, p = 0.004) and inflammation and malnutrition components (OR: 2.21 and 3.31, 95% CI: 1.10–4.43 and 1.64–6.65, p = 0.030 and 0.001). On the other hand, occlusal support was not significantly associated with MIA syndrome or any of its components.Conclusion Periodontitis is associated with MIA syndrome, particularly with inflammation and malnutrition in hemodialysis patients, independent of occlusal support.