bluuebunny/crossref_metadata_2025 huggingface dataset:
Sarcoidosis–lymphoma syndrome: a diagnostic dilemma
Authors: Oskuei Assad , Hicks Lisa , Ghaffar Hasan , Hoffstein Victor
Published: December 2017

Sarcoidosis and lymphoma are generally thought of as being two mutually exclusive diseases that need to be considered in the differential diagnosis of patients with hilar/mediastianal lymphadenopathy. However, there are rare patients in whom both of these diseases coexist. These patients constitute a diagnostic challenge because their presentation (ie, clinical symptoms, imaging abnormalities and even pathology) may all be atypical when each individual disease is considered separately. In this report, we describe a patient who presented with such atypical features and was eventually diagnosed as having both sarcoidosis and a B-cell lymphoma with features of splenic marginal zone lymphoma (SMZL) simultaneously. To our knowledge, this is only the second reported case of SMZL and sarcoidosis in the same patient.
Nerve terminals at the human corneoscleral limbus
Authors: Al-Aqaba Mouhamed A , Anis Fady S , Mohammed Imran , Dua Harminder S
Published: December 2017

Aims

To demonstrate and characterise distinct subepithelial compact nerve endings (CNE) at the human corneoscleral limbus.

Methods

Ten fresh human donor corneoscleral discs (mean age, 67 years) and 26 organ-cultured corneoscleral rims (mean age, 59 years) were studied. All samples were subjected to enzyme histochemical staining related to endogenous acetylcholinesterase present in nerve tissue and H&E staining. Whole-mount en face imaging with NanoZoomer digital pathology microscope and serial cross-section imaging with light microscope were undertaken.

Results

Nerves entering the corneoscleral limbus and peripheral cornea terminate under the epithelium as enlarged multiloculated and multinucleated ovoid structures within a 2 mm zone. They are closely associated with the rete pegs of the limbal palisades and the limbal epithelial crypts, often located within characteristic stromal invaginations of these structures. Their numbers ranged from 70 to 300 per corneoscleral rim. The size ranged from 20 to 100 µm. They had one or more nerve connections and were interconnected to other similar endings and to the limbal nerve plexus.

Conclusion

Human corneoscleral limbus demonstrates a population of nerve terminals resembling CNE with distinct morphological features. They are closely associated with the limbal stem cell niches, suggesting a potential contribution to the niche environment.
Protocol of a single group prospective observational study on the diagnostic value of 3T susceptibility weighted MRI of nigrosome-1 in patients with parkinsonian symptoms: the N3iPD study (nigrosomalironimagingin Parkinson’s disease)
Authors: Schwarz Stefan T , Xing Yue , Naidu Saadnah , Birchall Jim , Skelly Rob , Perkins Alan , Evans Jonathan , Sare Gill , Martin-Bastida Antonio , Bajaj Nin , Gowland Penny , Piccini Paola , Auer Dorothee P
Published: December 2017

Introduction

Parkinson’s disease (PD) is the most common movement disorder in the elderly and is characterised clinically by bradykinesia, tremor and rigidity. Diagnosing Parkinson’s can be difficult especially in the early stages. High-resolution nigrosome MRI offers promising diagnostic accuracy of patients with established clinical symptoms; however, it is unclear whether this may help to establish the diagnosis in the early stages of PD, when there is diagnostic uncertainty. In this scenario, a single photon emission CT scan using a radioactive dopamine transporter ligand can help to establish the diagnosis, or clinical follow-up may eventually clarify the diagnosis. A non-invasive, cost-effective diagnostic test that could replace this would be desirable. We therefore aim to prospectively test whether nigrosome MRI is as useful as DaTSCAN to establish the correct diagnosis in people with minor or unclear symptoms suspicious for PD.

Methods and analysis

In a prospective study we will recruit 145 patients with unclear symptoms possibly caused by Parkinson’s from three movement disorder centres in the UK to take part in the study. We will record the Movement Disorder Society - Unified Parkinson’s Disease Rating Scale, and participants will undergo DaTSCAN and high-resolution susceptibility weighted MRI at a field strength of 3T. DaTSCANs will be assessed visually and semiquantitatively; MRI scans will be visually assessed for signal loss in nigrosome-1 by blinded investigators. We will compare how the diagnosis suggested by MRI compares with the diagnosis based on DaTSCAN and will also validate the diagnosis based on the two tests with a clinical examination performed at least 1 year after the initial presentation as a surrogate gold standard diagnostic test.

Ethics and dissemination

The local ethics commission (Health Research Authority East Midlands – Derby Research Ethics Committee) has approved this study (REC ref.: 16/EM/0229). The study is being carried out under the principles of the Declaration of Helsinki (64th, 2013) and Good Clinical Practice standards. We have included a number of 15 research-funded DaTSCAN in the research protocol. This is to compensate for study site-specific National Health Service funding for this investigation in affected patients. We therefore have also obtained approval from the Administration of Radioactive Substances Administration Committee (ARSAC Ref 253/3629/35864). All findings will be presented at relevant scientific meetings and published in peer-reviewed journals, on the study website, and disseminated in lay and social media where appropriate.

Trial registration number

NCT03022357; Pre-results.
Accuracy of recall of musculoskeletal injuries in elite military personnel: a cross-sectional study
Authors: Lovalekar Mita , Abt John P , Sell Timothy C , Lephart Scott M , Pletcher Erin , Beals Kim
Published: December 2017

Background

Self-reported data are often used in research studies among military populations.

Objective

The accuracy of self-reported musculoskeletal injury data among elite military personnel was assessed for issues with recall.

Design

Cross-sectional study.

Setting

Applied research laboratory at a military installation.

Participants

A total of 101 subjects participated (age 28.5±5.6 years). Study participants were active duty military personnel, with no conditions that precluded them from full duty.

Primary and secondary outcome measures

Self-reported and medical record reviewed injuries that occurred during a 1-year period were matched by anatomic location, injury side (for extremity injuries), and injury year and type. The accuracy of recall was estimated as the per cent of medical record reviewed injuries correctly recalled in the self-report. The effect of injury anatomic location, injury type and severity and time since injury, on recall, was also assessed. Injuries were classified as recent (≤4 years since injury) or old injuries (>4 years since injury). Recall proportions were compared using Fisher’s exact tests.

Results

A total of 374 injuries were extracted from the subjects’ medical records. Recall was generally low (12.0%) and was not different between recent and old injuries (P=0.206). Injury location did not affect recall (P=0.418). Recall was higher for traumatic fractures as compared with less severe non-fracture injuries (P values 0.001 to <0.001). Recall for non-fracture injuries was higher for recent as compared with old injuries (P=0.033). This effect of time since injury on recall was not observed for fractures (P=0.522).

Conclusions

The results of this study highlight the importance of weighing the advantages and disadvantages of self-reported injury data before their use in research studies in military populations and the need for future research to identify modifiable factors that influence recall.
Factors associated with high levels of glycated haemoglobin in patients with type 1 diabetes: a multicentre study in Brazil
Authors: Andrade Carine Sousa , Ribeiro Guilherme Sousa , Santos Carlos Antonio Souza Teles , Neves Raimundo Celestino Silva , Moreira Edson Duarte
Published: December 2017

Objective

Long-term complications of type 1 diabetes mellitus (DM1) can be prevented with adequate glycaemic control. However, high levels of glycated haemoglobin (HbA1c) occur in 60%–90% of the patients with DM1. Thus, we aimed to investigate the role of sociodemographic, behavioural and clinical factors on the HbA1c levels of patients with DM1 in Brazil.

Design, setting and participants

A cross-sectional study was conducted in ambulatory patients with DM1 aged ≥18 years from 10 Brazilian cities. Sociodemographic, behavioural and clinical data were obtained through interviews.

Main outcome measures

HbA1c level was measured by liquid chromatography. Hierarchical multiple variable linear regression models were used to identify factors correlated with high levels of HbA1c.

Results

Of 979 patients with DM1, 63.8% were women, and the mean age was 40 (SD 14.6) years. The mean HbA1c level was 9.4% (SD 2.2%), and 89.6% of the patients had HbA1c ≥7.0%. Factors independently correlated with increased HbA1c levels included: lower education, non-participation in diabetes classes/lecture during the year before, having a self-perception of poor adherence to diet and insulin, not having private medical care and not measuring the HbA1c levels in the prior year. Of note, poor adherence to diet and insulin were the independent factors most strongly associated with high levels of HbA1c (mean increment in HbA1c levels of 0.88% and 1.25%, respectively).

Conclusion

Poor glycaemic control, which is common among Brazilian patients with DM1, is associated with lower education, self-perception of insufficient adherence to diet and insulin and inadequate monitoring of HbA1c levels. Specific actions, particularly those targeting improving adherence to diet and insulin, may contribute to successful management of patients with DM1.
Cross-sectional surveys of the amount of sugar, energy and caffeine in sugar-sweetened drinks marketed and consumed as energy drinks in the UK between 2015 and 2017: monitoring reformulation progress
Authors: Hashem Kawther M , He Feng J , MacGregor Graham A
Published: December 2017

Objectives

To investigate the sugar, energy and caffeine content of sugar-sweetened drinks marketed and consumed as energy drinks available in the UK.

Study design

We carried out a cross-sectional survey in 2015 and 2017 of energy drinks available in the main UK retailers.

Methods

The sugar (sugars g/100 mL), energy (kcal/100 mL), caffeine (mg/100 mL) and serving size were collected from product packaging and nutrition information panels of energy drinks available in the nine main UK grocery retailers, three health and beauty retailers and one convenience store.

Results

The number of formulations (per 100 mL) and number of products (per serving) have fallen (from 75 to 49 and from 90 to 59) between 2015 and 2017, respectively. Energy drinks surveyed showed a 10% reduction in sugar, from 10.6 to 9.5 g/100 mL (P=0.011) and a 6% reduction in energy content (P=0.005) per 100 mL between 2015 and 2017. The average caffeine content of energy drinks, with a warning label, has remained high at 31.5±0.9 in 2015 and 31.3±1.0 mg/100 mL in 2017. Despite there being reductions, sugar, energy and caffeine content remain at concerning levels in 2017.

Conclusions

To reduce the harmful impact of energy drinks, further reduction in sugar and a reduction in caffeine by reformulation are urgently needed. Other measures such as ban on the sale of energy drinks to children and smaller product sizes should also be explored, while warning labels should be kept. A reduction in sugar, energy and caffeine content and overall energy drinks consumption could be beneficial in reducing sugar, energy and caffeine intake of consumers of energy drinks.
Systematic review of the implementation of audience response systems and their impact on participation and engagement in the education of healthcare professionals
Authors: Iskander Morkos
Published: December 2017

Background

Audience response system provides a mechanism to engage larger groups as active participants in teaching sessions. However, they are traditionally based on ‘fixed’ closed loop system, which limits their functionality to a single geographical location, thus has the effect of confining their use to universities and other larger institutions, with a primary focus on education. Conversely, in the healthcare education context, the majority of formal education is undertaken through postgraduate training programmes, largely conducted in smaller cohorts in clinical settings.

Objective

The purpose of this review is to evaluate audience response systems in terms of feasibility of implementation and the impact on participation within the field of education of healthcare professionals, in comparison to the non-healthcare education.

Study selection

Therefore, systematic structured searches of PubMed and Medline databases for healthcare education were conducted, and Scopus, Education Resources Information Center, British Education Index, Education Abstracts, Education Administration Abstracts and PsycINFO databases for non-healthcare education databases.

Findings and conclusions

Consistent and fundamental differences were found in the studies evaluating healthcare education compared with other fields, with more difficulties encountered in implementation and a less significant impact on engagement seen. Here we discuss the consequences of these findings on the use of audience response systems and beyond.
Interpolating spatially varying soil property values from sparse data for facilitating characteristic value selection
Authors: Zhao Tengyuan , Montoya-Noguera Silvana , Phoon Kok-Kwang , Wang Yu
Published: December 2017

Limit state design, incorporated into many recent geotechnical design codes, introduces the application of partial or resistance factors to selected characteristic values. Partial or resistance factors are usually set by national standard organizations, while characteristic values of geotechnical parameters are selected by engineers, often based on sparse measurement data combined with subjective engineering experience and judgment. Due to this subjective selection and individual judgment, the characteristic value derived by different engineers from the same dataset may vary greatly, especially when the test data contain significant variability. To address this issue, a new method based on Bayesian compressive sampling (BCS) is proposed in this study. BCS is able to reconstruct a high-resolution geotechnical property profile from sparse measurement data and quantify the uncertainty, e.g., confidence interval (CI) associated with the interpreted profile. The quantified uncertainty in the BCS has a clear statistical meaning: the corresponding confidence level for a CI from the BCS is the expected coverage proportion (i.e., fraction) of the complete profile that falls within the CI, if all data points along depth can be measured to provide the complete profile. This statistical meaning can be used to facilitate objective determination of characteristic values for geotechnical properties.
The effect of a metamaterial-based wearable microstrip patch antenna on the human body
Authors: Tetik Erkan , Tetik Gamze D.
Published: December 2017

Body-worn communication devices have attracted much attention due to their wide applications. In this regard, various wearable antennas that have lots of advantages have been designed by researchers in recent years. Metamaterials that have negative refractive index can also be used in the wearable antenna designs because they have an ability to eliminate harmful health effects. In this study, a metamaterial-based wearable microstrip patch textile antenna operating in industrial, scientific, and medical bands was designed and simulated. The radiation values of this antenna were analyzed. Then metamaterial-based electromagnetic band gap (EBG) structure and wearable antenna integration was designed. Two different integrated antenna designs (3 × 3 and 5 × 3) were proposed. We obtained the performances of these antenna designs and calculated the specific absorption rate (SAR) values. We calculated the absorbed power 48.8, 0.167, and 0.0485 W/kg for 10 g tissue of wearable microstrip patch antenna, EBG integrated wearable antenna with 3 × 3 design, and EBG integrated wearable antenna with 5 × 3 design, respectively. Because the SAR values of the EBG integrated wearable antenna designs are well below the standard values, we can say that the designs proposed in the study can be used in many areas, such as military, health monitoring, and wireless communication.
A short introduction to κ-deformation
Authors: Kowalski-Glikman J.
Published: December 2017

In this short review we describe some aspects of [Formula: see text]-deformation. After discussing the algebraic and geometric approaches to [Formula: see text]-Poincaré algebra we construct the free scalar field theory, both on noncommutative [Formula: see text]-Minkowski space and on curved momentum space. Finally, we make a few remarks concerning the interacting scalar field.
Stochastic Dynamic Analysis of an Offshore Wind Turbine Considering Frequency-Dependent Soil–Structure Interaction Parameters
Authors: Banerjee Arundhuti , Chakraborty Tanusree , Matsagar Vasant
Published: December 2017

This study investigates the dynamic response of a 5[Formula: see text]MW offshore wind turbine with monopile foundation subjected to wind and wave actions under parked condition. It includes dynamic interaction between the monopile and the underlying soil subjected to stochastic wind and wave loading. The offshore wind turbine tower has been modeled using the finite element software ANSYS 14 as a line structure and it comprises a rotor blade system, a nacelle, and a flexible tower under parked condition. The mass of the rotor, blade, and nacelle are lumped at the top of the tower for simplicity. Stochastic wind and wave loadings are simulated using the Kaimal spectrum and the Pierson–Moskowitz spectrum correlating wind and wave forces, respectively. The soil–structure interaction (SSI) effect at the foundation level is taken into consideration by including rotational as well as lateral spring constants derived from Wolf’s double cone model for embedded foundations. The results are studied in the frequency domain for both wind and wave loadings in the form of power spectral density functions, which show that the response of the structure depends not only on the external forces but also on the soil–structure interaction effect. Under very soft soil conditions, the displacement response is amplified to a very high value under wind loading when compared with that under wave loading at lower frequencies. Incorporation of soil–structure interaction also modified the peak value of displacement and its subsequent frequency when compared with that for the fixed base structure which does not consider soil–structure interaction.
A SIMPLIFIED INTRAVENOUS GLUCOSE TOLERANCE TESTING WITH MINOR MODIFICATIONS IS CLINICALLY APPLICABLE FOR CLIENT-OWNED CATS
Authors: Chen Yi-Ta , Su Bi-Ling
Published: December 2017

Type 2 diabetes mellitus (DM) is the most common form of DM in cats and humans. The intravenous glucose tolerance test is the recommended method for evaluating glucose homeostasis in cats. However, the requirements for anesthesia and hospitalization have prevented the clinical application of this test. To evaluate the clinical applicability of the simplified intravenous glucose tolerance test (SIVGTT) with minor modifications for client-owned cats, 38 client-owned cats with variable body weight were collected. The cats were divided into obese and lean groups based on body weight and feline body mass index (FBMI). All the cats were fasted for 12[Formula: see text]h. The owners accompanied the cats for catheter placement and during the entire duration of the test. The cats were covered with towels, and their blood was drawn via an extension of a winged infusion set. Glucose and insulin concentrations were measured before glucose injection (1.0[Formula: see text]g/kg) and at 5, 10, 15, 30, 45, 60, 90 and 120 min after glucose administration for the modified SIVGGT. A complete evaluation was achieved in 32 of the 38 cats (84%) using the modified SIVGTT, and significant differences between obese and lean cats were detected. The results are, in similar to previous reports in which the cats were hospitalized and anesthetized. In addition, three glucose-intolerant cats were identified by the test. Taken together, the modified SIVGTT was proven to bed clinically applicable, and it could be recommended in the future for the evaluation of glucose homeostasis in cats.
Study on the Landscape Pattern of Dalian Jinshitan National Holiday Resort in the Context of Tourism Urbanization
Authors: ZHANG Ruiying , XI Jianchao , ZHANG Nan
Published: December 2017

Resort-based urbanization is an important form of tourism urbanization. The paper analyzes the basic characteristics and diversity of landscape elements under the influence of the tourist development of Jinshitan National Holiday Resort (JNHR), discusses the changes in the spatial distribution of landscapes, and reveals how landscapes have changed under the influence of the tourism development of JNHR. The study shows that the whole landscape at Jinshitan has undergone a process from fragmentation to integration in the context of manmade tourism development and interference. As more tourism projects are developed, supporting infrastructures and facilities are continuously improved. Landscapes in Jinshitan have been vigorously developed in depth and extended from coastal area to inland area. As shown by the changing spatial distribution of relocated and commercial housing estates since 1992, there have been differences in the location, living environment and available landscapes between the housing estates, indicating the heterogeneity of social space and inequality in the living environment.
Characteristics and Potential for Successful Co-Creation
Authors: Rasool Faisal , Koomsap Pisut , Costa Meghla Clara
Published: December 2017

Co-creation, an active end-users involvement in product development process, has been recognized as an effective way of minimizing risk of misinterpretation of end-user needs and achieving product success. Furthermore, high level of co-creation has seemed to create high perceived value to products. With an aim of encouraging many more firms to involve their end-users in the product development process, a quantitative tool developed to help the firms evaluate their readiness and potential for co-creation is presented in this paper. Important characteristics for co-creation have been established from the literature and have been classified with the help of expert opinion into three different levels: must-have, should-have and nice-to-have. The firms that fulfill all the must-have characteristics are ready for co-creation, and their potential is evaluated from the should-have and nice-to-have characteristics. An exploratory case study on three shoe manufacturers was conducted for illustration.
Computation of Stackelberg Equilibria of Finite Sequential Games
Authors: Bošanský Branislav , Brânzei Simina , Hansen Kristoffer Arnsfelt , Lund Troels Bjerre , Miltersen Peter Bro
Published: December 2017

The Stackelberg equilibrium is a solution concept that describes optimal strategies to commit to: Player 1 (
the leader
) first commits to a strategy that is publicly announced, then Player 2 (
the follower
) plays a best response to the leader’s choice. We study the problem of computing Stackelberg equilibria in finite sequential (i.e., extensive-form) games and provide new exact algorithms, approximation algorithms, and hardness results for finding equilibria for several classes of such two-player games.
Homologous Recombination Deficiency and Platinum-Based Therapy Outcomes in Advanced Breast Cancer
Authors: Zhao Eric Y. , Shen Yaoqing , Pleasance Erin , Kasaian Katayoon , Leelakumari Sreeja , Jones Martin , Bose Pinaki , Ch'ng Carolyn , Reisle Caralyn , Eirew Peter , Corbett Richard , Mungall Karen L. , Thiessen Nina , Ma Yussanne , Schein Jacqueline E. , Mungall Andrew J. , Zhao Yongjun , Moore Richard A. , Den Brok Wendie , Wilson Sheridan , Villa Diego , Shenkier Tamara , Lohrisch Caroline , Chia Stephen , Yip Stephen , Gelmon Karen , Lim Howard , Renouf Daniel , Sun Sophie , Schrader Kasmintan A. , Young Sean , Bosdet Ian , Karsan Aly , Laskin Janessa , Marra Marco A. , Jones Steven J.M.
Published: December 2017

Purpose: Recent studies have identified mutation signatures of homologous recombination deficiency (HRD) in over 20% of breast cancers, as well as pancreatic, ovarian, and gastric cancers. There is an urgent need to understand the clinical implications of HRD signatures. Whereas BRCA1/2 mutations confer sensitivity to platinum-based chemotherapies, it is not yet clear whether mutation signatures can independently predict platinum response.

Experimental Design: In this observational study, we sequenced tumor whole genomes (100× depth) and matched normals (60×) of 93 advanced-stage breast cancers (33 platinum-treated). We computed a published metric called HRDetect, independently trained to predict BRCA1/2 status, and assessed its capacity to predict outcomes on platinum-based chemotherapies. Clinical endpoints were overall survival (OS), total duration on platinum-based therapy (TDT), and radiographic evidence of clinical improvement (CI).

Results: HRDetect predicted BRCA1/2 status with an area under the curve (AUC) of 0.94 and optimal threshold of 0.7. Elevated HRDetect was also significantly associated with CI on platinum-based therapy (AUC = 0.89; P = 0.006) with the same optimal threshold, even after adjusting for BRCA1/2 mutation status and treatment timing. HRDetect scores over 0.7 were associated with a 3-month extended median TDT (P = 0.0003) and 1.3-year extended median OS (P = 0.04).

Conclusions: Our findings not only independently validate HRDetect, but also provide the first evidence of its association with platinum response in advanced breast cancer. We demonstrate that HRD mutation signatures may offer clinically relevant information independently of BRCA1/2 mutation status and hope this work will guide the development of clinical trials. Clin Cancer Res; 23(24); 7521–30. ©2017 AACR.
The Home Literacy Environment of Preschool-Age Children with Autism or Down Syndrome
Authors: Westerveld Marleen , van Bysterveldt Anne K.
Published: December 2017

Aims: This exploratory study investigated if there were differences in the home literacy environment of preschool children on the autism spectrum and preschool children with Down syndrome to determine if the home literacy environment may potentially be associated with strengths or weaknesses in children’s social communication skills. Methods: A total of 111 parents of preschoolers with identified disabilities completed a home literacy questionnaire. Results: Results indicated that both groups of parents started reading to their children at an early age and owned at least 25 children’s books. However, parents of children with Down syndrome read to their child more often, reported higher child interest in reading, and more frequently played rhyming games with their child. No group differences were found in teaching of letter names, although parents of children with autism reported a higher frequency of pointing out signs/words in the environment and reported their children knew more letter names. Group differences were also found in the relationship between parent behaviours, child interest, and children’s print-related skills. Conclusion: This study highlights the influence both parent behaviours and child interest may have on shared book reading practices of parents with their preschool children with disabilities.
Portal Vein Embolization: State-of-the-Art Technique and Options to Improve Liver Hypertrophy
Authors: Huang Steven Y. , Aloia Thomas A.
Published: December 2017

Portal vein embolization (PVE) is associated with a high technical and clinical success rate for induction of future liver remnant hypertrophy prior to surgical resection. The degree of hypertrophy is variable and depends on multiple factors, including technical aspects of the procedure and underlying chronic liver disease. For patients with insufficient liver volume following PVE, adjunctive techniques, such as intra-portal administration of stem cells, dietary supplementation, transarterial embolization, and hepatic vein embolization, are available. Our purpose is to review the state-of-the-art technique associated with high-quality PVE and to discuss options to improve hypertrophy of the future liver remnant.
The Role of Vascular Calcification in Heart Failure and Cognitive Decline
Authors: Cheng Hao-Min , Wang Jiun-Jr , Chen Chen-Huan
Published: December 2017

Vascular calcification is heterogeneous and triggered by multiple mechanisms. It has been implicated in the development of heart failure with preserved ejection fraction (HFpEF) and cognitive function impairment. Understanding the pathophysiology of vascular calcification may help us improve the management of HFpEF, atherosclerosis, accelerated arterial stiffness, hypertension, and cognitive dysfunction. Currently, there are no effective strategies for treating accelerated arterial stiffness. This may indicate that once arterial stiffness or vascular calcification has developed, it may be less likely to stop the ongoing pathophysiology. Therefore, earlier intervention targeting the probable pathways of vascular calcification may benefit the patients with vascular calcification and related pathological conditions. In this review, we briefly discuss the proposed pathophysiological roles of vascular calcification in the development of heart failure and cognitive decline, the animal models used to study the link between vascular calcification and cardiovascular diseases, and the possible corresponding management strategies.
Intraductal Papillary Mucinous Neoplasms of the Pancreas: Strategic Considerations
Authors: Morales-Oyarvide Vicente , Fong Zhi Ven , Fernández-del Castillo Carlos , Warshaw Andrew L.
Published: December 2017

Intraductal papillary mucinous neoplasms (IPMN) are cystic neoplasms with the potential for progression to pancreatic cancer. Recognized by the global medical community just over two decades ago, IPMN have gained great epidemiological and clinical relevance thanks to the widespread use of cross-sectional abdominal imaging, which has led to a surge in the number of incidental pancreatic cysts being diagnosed. As our understanding of this disease has improved, we now know that some IPMN have a very elevated risk of cancer and require surgical resection, while others are low-risk lesions and can be followed. The approach to IPMN must therefore strike a balance between preventing the over-utilization of surgery and the timely recognition and treatment of patients with high-risk lesions. Several clinical, radiographic, and laboratory parameters have been proposed to risk-stratify IPMN, leading to the publication of management guidelines that do not always converge in their recommendations. The goal of this clinical therapeutic review is to describe the strategic approach to IPMN at the Massachusetts General Hospital, and how our current understanding, management algorithm, and future directions have been informed by research efforts at our institution and other centers.
Screening for Fabry Disease in Kidney Disease: a Cross-Sectional Study in Males and Females
Authors: Sodré Luciana Senra de Souza , Huaira Rosália Maria Nunes Henriques , Bastos Marcus Gomes , Colugnati Fernando Antônio Basile , Coutinho Marcelo Paula , Fernandes Natália Maria da Silva
Published: December 2017

Background/Aims: Evaluate the prevalence of Fabry disease in men and women with kidney disease; and observe the presence and importance of the main signs and symptoms in patients with kidney disease. Methods: A cross-sectional analysis of secondary data from a multicenter project of Clinical and Epidemiological Analysis of Fabry Disease in 854 Dialysis Centers. A total of 36,442 patients underwent the questionnaire and algorithm; of them, 28,284 were discarded for not presenting signs and symptoms of Fabry disease, while the other 8,087 submitted to blood collection and analysis. All participants signed a Free and Informed Consent Form and a questionnaire was applied. The questionnaire data were analyzed using a computerized algorithm. This program/algorithm analyzes and separates patients into: discarded, patients unlikely to have Fabry disease; suspect, patients who submitted to blood collection. The blood of suspect patients was collected on filter paper for enzyme measurement and genetic testing. A descriptive data analysis was performed and the likelihood ratio was determined. Results: The general prevalence was 0.19% and after use of algorithm was 0.87%. Although more men were screened (59.3%), the prevalence was higher in women (65.1%). The most prevalent signs and symptoms were: heart disease (60.6%), decreased or lack of sweating (42.3%), heat and cold intolerance (28.2%), and pain crises spreading throughout the body (26.8%). Conclusion: The prevalence was higher in women, and the most prevalent symptom was heart diseases.
Leibniz x Arnauld: A quarrel around the divine freedom
Authors: Silva Antonio Felipe Araújo
Published: December 2017

Os conceitos de vontade e entendimento em Deus, da forma como trata Leibniz na correspondência com Arnauld de 14 de julho de 1686, nos ajuda a visualizar, numa certa perspectiva, a forma como Leibniz preserva a possibilidade de ações contingentes num mundo regido pelo princípio de razão. Nesta correspondência, o foco de Leibniz está na diferenciação conceitual entre noções substanciais e noções específi cas. Por trás dessa diferenciação está exatamente a consideração dos conceitos de vontade e entendimento em Deus, os quais serão abordados neste trabalho
Bergson’s Role in the Deleuzian conception of Being as alteration
Authors: Corbanezi Eder Ricardo
Published: December 2017

Neste artigo, procuramos apresentar como a filosofia de Bergson fornece a Deleuze elementos para a constituição de uma ontologia complexa, fundamentada em uma noção de Ser como multiplicidade, alteração, diferença
Interiority, Exteriority and Language in Saint Augustine
Authors: Forattini Fernando Miramontes
Published: December 2017

Com este trabalho, pretendo abordar a relação entre exterioridade, interioridade e linguagem em Santo Agostinho. Para isso, pretendo abordar o que é o conceito de signo e outras relações, a saber, o signo com a exterioridade e o signo com a linguagem. Também pretendo demonstrar como a divisão proposta por John F. Crosson, muda completamente o que creio ser a visão de Santo Agostinho sobre o que é e como ocorre o ensinamento de Cristo. Tomarei como base as obras De Magistro, Confissões e A Trindade, embora haja análises sobre a linguagem e os signos em outras obras de Santo Agostinho, como por exemplo, em De Dialectica
Verbal signals of the Verb: A Study on Language and Interiority in Augustine
Authors: Pinheiro Flávio Macedo
Published: December 2017

A meditação proposta por Agostinho no diálogo De Magistro aponta para as limitações da linguagem. A partir desse apontamento, Agostinho passa a interiorizar o papel da linguagem, percebendo que apenas os verbos exteriores não conseguem alcançar o que o homem mais carece: a Verdade. Porém, essa falha não impossibilita o homem de buscar a Verdade, e sim serve de exercício para que ele perceba que toda a verdade provém do verbo interior, que aponta para Cristo, a própria Verdade divina encarnada, o Verbo de Deus
Essays on Education, Free Time and Work
Authors: Cohon José Calixto Kahil
Published: December 2017

Trata-se de refletir sobre as relações entre educação, tempo livre e trabalho no interior da sociedade contemporânea. A educação hoje em dia é pensada diretamente para o mercado de trabalho, neste sentido é preciso denunciar a industrialização da educação e analisá-la criticamente. Com a educação voltada ao trabalho, sua relação com seu oposto, o tempo livre, tornase imanente. Reivindicar criticamente a educação em todos os âmbitos da vida é o objetivo deste texto
Anselm’s unique argument
Authors: Costa Lessandro Regiani
Published: December 2017

O objetivo deste trabalho é, por meio da leitura do capítulo II do Proslogion, compreender alguns movimentos do texto, tais como a relação com a fé, o nome de Deus e a superioridade da coisa
Heidegger: Technique and World Picture
Authors: Silva Pedro Ivo Ferraz da
Published: December 2017

O artigo apresenta alguns aspectos da investigação de Heidegger sobre a técnica, introduzindo e aproximando, para tanto, dois textos do autor: “O tempo da imagem de mundo” e “A Pergunta pela Técnica”. Trata-se de confrontar a definição que o filósofo deu à essência da técnica moderna com a metafísica da “imagem de mundo” que atribuiu à modernidade. Neste empenho, é ainda destacado o caráter inovador com que Heidegger abordou o assunto, afastando-se dos debates correntes que se limitavam a questionar a neutralidade e os aspectos culturais da técnica
Jürgen Habermas and the equiprimordial relationship between human rights and popular sovereignty
Authors: Santos Caio Felix dos
Published: December 2017

Os direitos humanos e a soberania popular – respectivamente, autonomia privada e a autonomia pública, em uma outra terminologia – formam a base normativa da compreensão moderna de democracia. Na obra Direito e Democracia, Habermas busca fundamentar um sistema de direitos capaz de abarcar as categorias referentes aos direitos fundamentais que comporiam uma constituição democrática. Trata-se do conjunto de direitos que os cidadãos devem atribuir-se mutuamente com vistas à auto-organização jurídica de sua própria comunidade política. Neste empreendimento, Habermas buscará demonstrar que a aparente tensão entre os direitos humanos, garantidores de liberdades subjetivas, e a soberania popular, entendida como a autolegislação coletiva de uma comunidade política, é desfeita quando se busca compreender a democracia a partir de uma teoria discursiva da formação da opinião e da vontade políticas
Experimental analysis of popular ceramics: Conceição das Creoulas - Salgueiro - PE
Authors: Alves Cláudia , Borges Lucila Ester Prado , Leo Hugo S. Villarroel , Vanderlei Kalina
Published: December 2017

O artigo apresenta um estudo da tecnologia cerâmica utilizada por ceramistas atuais do Distrito de Conceição das Creoulas localizado no município de Salgueiro, Estado de Pernambuco. Foram registrados todos os procedimentos técnicos desde a coleta da argila à produção dos vasilhames cerâmicos. Na caracterização do tipo de pasta dos vasilhames cerâmicos e do tipo de barro empregado por essas ceramistas, aplicamos técnicas como a difratometria de Raios X, análise química, análise petrográfica, análise granulométrica, índice de consistência dos solos e ensaio de limite de contração. Essas análises permitiram identificar dois tipos de materiais que possuem origens diferentes, as técnicas de produção e temperatura de queima da cerâmica.
Ports of Ribeira Valley, São Paulo: an archaeological approach
Authors: Camargo Paulo Fernando Bava de
Published: December 2017

apesar do transporte marítimo de cargas e passageiros ter se extinguido no Vale do Ribeira paulista há vários anos e de a região hoje ser considerada economicamente decadente, os portos da região continuam bastante ativos em razão da pesca comercial e do turismo náutico. Como a arqueologia marítima pode ajudar na resolução desse aparente paradoxo? Observando as estruturas portuárias atuais e analisando criteriosamente aquelas que aparentemente apresentam maior antiguidade, levando à compreensão da transformação dos modos de produção ocorrida entre o século XIX e o XX
Study of lithic industry of Água Limpa Site, from Monte Alto, São Paulo State: 1995, 1996 and 2000 Campaigns
Authors: Belo Tais Pagoto
Published: December 2017

Este artigo é sobre a indústria lítica do Sítio Água Limpa, localizado em Monte Alto, São Paulo. O objetivo principal deste artigo é a análise da tecnologia através do estudo dos gestos técnicos associados às matérias-primas. Utilizou-se uma ficha tecnotipológica que possibilitou a compreensão dos processos que envolvem as cadeias operatórias e, por fim, a caracterização da cultura material lítica
The lithic industry of the small shell mounds of southern Brazilian coast, Santa Catarina: preliminary results
Authors: Belem Fabiana Rodrigues
Published: December 2017

Este artigo tem por objetivo apresentar os resultados preliminares obtidos com o sítio Lagoa dos Bichos II, situado no litoral sul catarinense. Trata-se de um sambaqui pequeno e não-funerário, com grande quantidade de artefatos líticos sobre sua superfície e periferia. Sua coleção encontra-se atualmente em estudo através do mestrado da própria autora. Procuramos desta forma, contribuir para enriquecer o entendimento do sistema de assentamento dos grupos construtores de sambaquis dessa região
Program for Archaeological Heritage Management in São Sebastião
Authors: Galdino Clayton
Published: December 2017

Sob orientação da professora Maria Cristina M. Scatamacchia, o presente trabalho tem com o objetivo oferecer bases para a consolidação de políticas públicas para o patrimônio arqueológico no município de São Sebastião, SE Para tal, preconiza as ações de reconhecimento e gestão da arqueoinformação, a aplicação e proposição de diplomas legais, a curadoria do acervo e a co-gestão do patrimônio arqueológico pela com unidade. Tal iniciativa já obteve resultados parciais que delineiam seus objetivos finais
Šaqiqan
Authors: Zaatari Akram , Nogueira Cléris
Published: December 2017

Tradução de Cléris Nogueira.HATOUM, Milton. Šaqiqan. Trad. S. A.-C. Jubran. Beirute: Dar Alfarabi, 2002, 255 p.
Epístola de Alfarabi intitulada “Respostas a questões sobre as quais foi questionado”
Authors: Iskandar Jamil Ibrahim
Published: December 2017

Reprodução do texto árabe e tradução portuguesa anotada da epístola de Alfarabi฀intitulada “Respostas a questões sobre as quais foi questionado”.
A arte sagrada no Oriente e no Ocidente – princípios e métodos
Authors: Napolitano Samuel
Published: December 2017

Burckhardt, Titus., 2004. A arte sagrada no Oriente e no Ocidente – princípios e métodos. Trad. E. C. Alves e S. Rizek. São Paulo: Attar Editorial, 267 pp.
Árabe e Português: Fonologia contrastiva com aplicação de tecnologias in
Authors: Zapparoli Zilda Maria
Published: December 2017

Jubran, Safa A. C., 2004. Árabe e Português: Fonologia contrastiva com aplicação de tecnologias in
O Livro das mil e uma noites de Cabral
Authors: Kossovitch Leon , Muhana Adma Fabul
Published: December 2017

Em 2004, Hélio Cabral fez uma série de ilustrações para a edição do Livro das mil e uma noites, que Mamede Jarouche traduziu diretamente do árabe, da qual uma pequena série é aqui publicada e analisada em suas relações entre pintura e texto, como inversão dos papéis, conjugação excludente dos caracteres e das ações e deslocamento por excesso da narrativa.
Influências orientais na língua portuguesa
Authors: Vargens João Baptista Medeiros
Published: December 2017

NIMER, Miguel. Influências orientais na língua portuguesa. 2ª. ed., São Paulo: Edusp, 2005.
Em Presença das Noites: O prólogo-moldura e “Os Quatro Talismãs” de Charles Nodier
Authors: Damien Christiane
Published: December 2017

Este trabalho apresenta uma análise comparada do prólogo-moldura de “Os Quatro Talismãs”, de Charles Nodier, relativamente aos prólogos-moldura de Les mille et une nuits – tradução do orientalista francês Antoine Galland – e das Noites árabes. Tal análise, baseada no teórico Gérard Genette, visa não somente situar as apropriações de Nodier a partir de Les mille et une nuits, mas também evidenciar os traços individuais do autor, que transforma o modelo provindo das Noites, imprimindo em “Os Quatro Talismãs” suas particularidades como também a perspectiva da tradição literária do Romantismo, a qual à qual ele pertence
O Ensino-Aprendizagem de Língua Árabe sob a Ótica da Teoria da Atividade
Authors: Hawi Mona Mohamad
Published: December 2017

Este artigo discute o ensino atual de língua árabe como língua estrangeira na Universidade de São Paulo e propõe uma reflexão quanto a uma aprendizagem que priorize maneiras de compreender e trabalhar o uso da língua, considerando conceitos advindos de uma base Só- cio-histórico-Cultural. Enxerga-se, nessa perspectiva, uma melhor forma de participação e envolvimento dos alunos ao considerar o contexto de produção que inclui contexto – organização – materialização da ação verbal. Essa questão não é claramente desenvolvida nos livros didáticos de ensino de língua árabe, motivo que levou a pesquisadora a elaborar unidades didáticas segundo a perspectiva de atividades sociais, ou seja, entender que a opção de ensinar-aprender deve considerar o contexto de vida atual, ou, conforme Marx e Engels (2006; 26), pensar e trazer à tona “a vida que se vive”. Assim, o foco recai sobre formas de ensinar, pautadas por uma reflexão sobre a vida (Liberali, 2009)
At the other side of the mirror
Authors: Vasconcelos Sandra G. T.
Published: December 2017

Poe e Machado problematizam a noção de real, ao transformá-lo num espaço de paradoxo e contradição. Através da figura do duplo, ambos os contistas criam narradores enigmáticos, colocando em questão as relações entre esses narradores e o público leitor
A "nova" literatura feminina alemã através de sucessos
Authors: Brink-Friederici Christl M. K.
Published: December 2017

A "nova " literatura alemã escrita por mulheres após a revolta estudantil de 1968 distingue-se por uma serie de sucessos tanto de público leitor quanto de crítica literária. As razões para esses acontecimentos são várias , como a novidade de mulheres escreverem sobre si mesmas ou os temas por elas escolhidos que tratam da sexualidade, homossexualidade feminina, troca de papéis e agressão contra o status quo de um a sociedade patriarcal. Examinaremos nesse artigo dez desses sucessos da "nova” literatura feminina alemã, começando com o romance “ Amo r de classes, de Karin Struck, de 1973, e concluindo com o de Elfried e Jelinek , chamado O desejo, de 1989
Leitura - construção de sentido
Authors: Langer Eliana Rosa
Published: December 2017

Este trabalho pretende ser uma reflexão sobre leitura como um processo de interação entre escritor/texto/leitor, do qual resultará a construção do sentido do texto pelo leitor.
Léxico, leitura e construção do sentido em língua estrangeira
Authors: Pietraróia Cristina Casadei
Published: December 2017

Esse artigo questiona o ensino da leitura em língua estrangeira, apontando algumas referências conceituais para a revalorização do léxico na apropriação dessa competência
Procedimentos de construção do texto falado: aspectualização
Authors: Barros Diana Luz Pessoa de
Published: December 2017

Neste trabalho examinam-se algumas questões sobre a aspectualização discursiva e lingüístico-textual em geral e dos textos conversacionais em particular, na perspectiva teórica da semiótica narrativa e discursiva. A aspectualização é estudada como um procedimento de construção do texto falado com diferentes manifestações correção, paráfrase, inserção, repetição, etc. A perspectiva adotada leva-nos, em primeiro lugar, a observar que tais procedimentos assumem ao menos dois papéis na construção do discurso: produzem efeitos de sentido ditos “patêmicos” e cumprem funções persuasivo-argumentativas; em segundo lugar, a descrever as relações de homologação e de isomorfismo que se estabelecem entre o plano da expressão e o do conteúdo dos textos conversacionais. Finalmente, o trabalho procura apontar as aproximações possíveis entre texto falado e texto poético, com base nos sistemas semi-simbólicos de correla­ ção entre expressão e conteúd
A exatidão imprecisa: Um ensaio sobre interdisciplinaridade, discurso e texto
Authors: Gamica Antonio Vicente Marafioti
Published: December 2017

Neste ensaio discutimos aspectos do trabalho com o texto de matemá­ tica, focando, a partir disso, temas como interdisciplinaridade, discurso e possibilidades de leituras/traduções do texto formalizado pelo imbricamento das linguagens fonnal e natural