bluuebunny/crossref_metadata_2025 huggingface dataset:
Pandemic and social protests: cities as flashpoints in the COVID-19 era
Authors:   Senior researcher, Global Cities, CIDOB, Garcia Chueca Eva , Teodoro Francesc ,   MSc candidate in Conflict Studies at London School of Economics, Foundation 'La Caixa' Fellow
Published: February 2022

Cities have been profoundly affected by the many problems caused by the COVID-19 pandemic: deteriorating public health, serious economic recession, deepening social divides, etcetera. These circumstances have become a hotbed of numerous expressions of social unrest which have crystallised in an especially significant way in urban settings. Hence, new social mobilisations have appeared, channelling the population’s criticisms of the health management of the crisis, or expressing ad hoc demands related with the social and economic problems caused by the pandemic. However, there are other demonstrations too, these being a continuation of pre-existing protests that have intensified as a result of the post-pandemic worsening of material conditions that caused them in the first place.
Evolutionary game research on the psychological choice of online shopping of fresh agricultural products based on dynamic simulation model
Authors: Li Jing
Published: February 2022

This article conducts a dynamic simulation on new agricultural product networks’ psychological selection based on the evolutionary game theory. Aiming at the characteristics of fresh agricultural products, the article analyses the dynamic evolution process of consumers’ strategic choice psychological state in the model. The research results show that the new agricultural products platform and the seller's strategic choice for the quality of the product are closely related to the output ratio of the input to the quality of the product. The users of fresh agricultural products are organically related through various network information behaviours, forming a networking group with a particular topological structure relationship.
A systematic review on Evaluation of Existing Face Eyes Detection Algorithms for Monitoring Systems
Authors: Ameen Sulaiman Maryam , Sarhan Kocher Idress
Published: February 2022

Among the many issues facing the world, the issue of traffic accidents, many security facilities have developed research on fingerprints, palmistry biometrics and other biometrics. In modern technologies, facial and eye detection algorithms have been developed and identified. This paper includes comparisons of face and eye tracking methods, which are extremely useful for identifying individuals in a variety of situations. Facial biometrics are more stable due to their distinct features, which gives them an advantage over other biometrics such as palmistry and fingerprint. This work dealt with 74 studies of face and eye detection and a comparison of algorithms that were used in previous researches, where the Viola-jones algorithm was identified as the best facial algorithm in terms of accuracy up to 98% for different types of face databases because this algorithm depends on geometry of face and also able to detect all faces in the same image, Furthermore, it has been determined that SVM is the best eye detection algorithm due to the accuracy of its characteristics and the speed of execution in real time so, the highest accuracy achieved was 98% accurate .
Shipbuilding 3D CAD Tools as an Integrated Solution from Concept to Product
Authors: Pérez-Martinez Jaime , Pérez Fernández Rodrigo
Published: February 2022

In the naval design process, there is still no consensus on the use of 3D CAD (Computer Aided Design) systems in the early stages of design. However, the integration capability of different modules is currently making their incorporation in the initial stages more appealing. The objective of this paper is to study the early stages of design as part of the whole process and to demonstrate the convenience of using a single 3D tool during the whole project.  Therefore, its impact on the whole design process will be analysed by considering the basic and early design capabilities of current CAD systems, reviewing how the main naval architecture and marine engineering demands match the features and what is the solution provided by the CAD for each case. The methodology presented offers advantages from a technical, economic and time point of view.
Estilo de pagos por servicios eco sistémicos desde la captura de carbono en la producción ganadera de Florencia, Caquetá
Authors: Balanta Martínez Víctor Julio , Varon Gonzalez Lizeth Viviana , Castro Cardona Yudis Marleydi , Lozada Anaya Yuri Ximena , Roa Duque Wilder Luvian
Published: February 2022

El presente artículo, tiene como objetivo identificar esquemas de pagos por servicios ambientales estimando la captura de carbono de la microcuenca de la quebrada la perdiz en Florencia Caquetá, para esto, se requiere la modelación de un PSA  que oferte buenos ingresos a la comunidad y la participación masiva en la ejecución de este proceso de acción tributaria. La pregunta de investigación que enmarco este trabajo se basó en: ¿Qué estilo por pago de servicios ambientales requieren materializar en las fincas ubicadas en la cuenca hidrográfica de la quebrada la Perdiz para el almacenamiento de Carbono en el Municipio de Florencia desde la función de sus agentes activos?, cuyo desarrollo se apoyó de la investigación descriptiva con enfoque cualitativo, por lo tanto, se detallaron los caracteres de la información seleccionada.  La metodología utilizada fue la revisión documental, desde estudios de proyectos, artículos, informes de revistas y demás extraídos desde la web, para posteriormente seleccionar la información, analizarla, discutirla y llegar a concluir sobre la misma. El documento se estructuro iniciando con un resumen que puntualizo todo lo contemplado en el artículo, la introducción como un preámbulo a la temática a desarrollar, para así llegar a unos resultados confrontados en la discusión y finalmente obtener unas conclusiones.
Long-term therapy of severe acne: selection of doses and administration schemes for systemic isotretinoin
Authors: Bakulev A. L. , Kravchenya S. S. , Platonova A. N. , Igonina I. A.
Published: February 2022

The article presents current data on the application of a systemic retinoid, isotretinoin, on the basis of the Lidose system for the treatment of patients with severe forms of acne. It also discusses issues of optimization of the daily dose of isotretinoin taking into consideration long-term clinical efficacy and safety of the therapy. The article presents the results of the authors’ study demonstrating the possibility to select mainly large or small doses of systemic isotretinoin depending on the treatment duration.
Development of a complex of preventive measures and their assessment to prevent the propagation of gonococcal infection in the arkhangelsk region
Authors: Kubanov A. A. , Baryshkov K. V. , Prib I. D. , Frigo N. V.
Published: February 2022

Goal of the study. To assess the efficacy of a complex of preventive measures developed in 2011-2012 for preventing the propagation of gonococcal infection in the Arkhangelsk region based on a study of the gonococcal infection morbidity dynamics in the territory of the region in 2011-2013. Study materials and methods: the authors analyzed statistics on the gonococcal infection morbidity in the territory of the Arkhangelsk region. To assess the efficacy of the complex of measures developed to prevent the propagation of gonococcal infection and other STDs in the Arkhangelsk region, the morbidity dynamics rate was calculated. Results. A complex of preventive measures for preventing the propagation of gonococcal infection in the Arkhangelsk region was developed in 2011 and was put to practical use in 2012. In 2012, the gonococcal infection morbidity rate grew in the Arkhangelsk region by 49.1% vs. 2011. Such a growth can be explained by the improved procedures for recording cases of gonococcal infection used in departmental and private medical organizations as well as optimization of the infection diagnostics methods including cultural tests and PCR, in particular, in women. In 2013, the incidence of gonococcal infection fell down as compared to 2012 (85.3 cases per 100,000 people in 2012 and 68.6 cases in 2013) including among teenagers (76.9 cases per 100,000 people in 2012 and 52.9 cases in 2013) in most municipal districts of the Arkhangelsk region (in 20 districts and towns, or 76.9% of the territory). Conclusions. Practical implementation of the complex of preventive measures developed to prevent the propagation of gonococcal infection and other STDs in the Arkhangelsk region substantially reduced the morbidity of gonococcal infection in the territory of the region. The collected data are sufficient to give a positive assessment of the developed measures and emphasize their contribution to the reduction of the morbidity of gonococcal infection.
A study of the correlation between acantholysis and apoptosis for the pathogenesis of pemphigus vulgaris
Authors: Karacheva YU. V. , Gaidash A. A. , Prokhorenkov V. I.
Published: February 2022

The goal of the study is to determine the particular features of pemphigus vulgaris (PV) morphogenesis and keratinocytes in the patients’ skin having morphological signs of acantholysis and apoptosis as well as changes in Langerhans cells. Materials and methods. Skin tissue samples taken from 46 PV patients were examined. The skin tissue samples underwent cytology, histopathology and immunohistochemistry examinations as well as transmission electronic microscopy. An increased number of CD1a+ (dendritic) cells and apoptotic Cpp3+ keratinocytes was revealed in the skin of the PV patients. According to the electronic microscopy data, keratinocytes with signs of apoptosis are present in fresh vesicles in the acantholysis area at early PV stages quite seldom; at the same time, Langerhans cells had morphologic signs of activation. As the number of keratinocytes with desmosome lysis signs grew, the number of apoptotic keratinocytes was increasing reliably. Conclusion. In case of PV, apoptosis has a secondary nature and develops as anoikis.
Combination therapy of acne in women: searching for optimum solutions
Authors: Goryachkina M. V. , Belousova T. A.
Published: February 2022

Current data on the acne pathogenesis are given. According to the authors, dermatosis is becoming more prevalent among women of mature age. Issues related to the clinical picture, effect of exogenous and endogenous factors on the course of acne, and psychosocial characteristics of delayed acne manifestations in women are described in detail. The essential role of medical and cosmetic products for the complex therapy of acne is discussed. The authors describe their own experience of treating delayed acne using the Hyseac line of medical and cosmetic products in a combination with microdermabrasion and no-needle mesotherapy using the vitaPeel/vital О2 device.
Syphilis incidence in Russian Federation in 2004-2013
Authors: Kubanova A. A. , Melekhina L. E. , Kubanov A. A. , Bogdanova E. V.
Published: February 2022

The article provides analysis of changes and structure of syphilis incidence in 2004-2013 in Russian Federation.
Molecular and genetic studies of the predisposition to the development of psoriasis among the population of the Russian Federation: a study of polymorphisms of TNFAIP3, TNIP1, TYK2 and REL genes
Authors: Kubanov A. A. , Mineyeva A. A.
Published: February 2022

Goal. To study the role of polymorphic variants of genes encoding proteins of the signaling pathway of the nuclear transcription factor kappa-B, NF-kB (TNFAIP3 (rs610604), TNIP1 (rs17728338), TYK2 (rs12720356) and REL (rs702873)) in the predisposition to psoriasis among the Caucasian population of the Russian Federation. Materials and methods. The authors studied markers of the predisposition to the development of psoriasis such as TNFAIP3 (rs610604), TNIP1 (rs17728338), TYK2 (rs12720356) and REL (rs702873) using Real-Time PCR methods and allele-specific oligonucleotide probes and PFLP (Restriction Fragment Length Polymorphism) assay in whole blood samples taken from psoriatic patients (n = 301). To compare the frequency of genotypes, the authors used data obtained as a result of the genotyping of DNAs taken from healthy volunteers (n = 109). Results. The authors analyzed particular features of the distribution of polymorphic variants of TNFAIP3 (rs610604), TNIP1 (rs17728338), TYK2 (rs1272035) и REL (rs702873) genes in a sample of 301 psoriatic patients and 109 healthy volunteers from the Russian Federation. They revealed reliable differences in the frequency of registration of genotypes of these genes. The authors also determined genotypes considered as risk factors with regard to the development of psoriasis (TNFAIP3-A/C, TNIP1-A/G, TNIP1-A/A and TYK2-T/T) as well as protector genotypes (TNFAIP3-A/Ä, REL-A/A and TYK2-T/G)
Verification of cutaneous leishmaniasis
Authors: Zaslavsky D. V. , Andriyenko YE. M. , Aleksandrova I. Y. , Matveyeva YE. L. , Semyonova S. YE. , Zuyev M. E. , Gaiduk A. A.
Published: February 2022

The article presents a case study of cutaneous leishmaniasis in a child. The patient stayed for several months in a leishmaniasis endemic area - in Tajikistan. This case is interesting from the point of view of verification of the infection that is not endemic in Russia.
Widespread scrofuloderma: a case study
Authors: Kuzmina N. V. , Rusak YU. E. , Popik O. V. , Borkhonova L. S.
Published: February 2022

The authors present a case study of scrofuloderma in a female patient aged 55; the patient’s condition was of interest due to the prevalence of the pathology and long-term (25 years) undiagnosed skin tuberculosis as a result of problems with the diagnostics of this localization of tuberculosis.
Dynamics of the sensitivity of N. gonorrhoeae strains found in the territory of the Russian Federation in 2010-2013 to antimicrobial drugs used for the treatment of gonococcal infection
Authors: Solomka V. S.
Published: February 2022

Goal of the study. To study the sensitivity of N. gonorrhoeae strains found in the territory of the Russian Federation in 2010- 2013 to antimicrobial drugs. Materials and methods. During the monitoring of antibiotic resistance of N. gonorrhoeae in 2010-2013, phenotypic properties of N. gonorrhoeae strains to antimicrobial drugs (penicillin, tetracycline, ciprofloxacin, spectinomycin, azithromycin and ceftriaxone) were examined by the agar serial dilution technique. As many as 1,305 viable N. gonorrhoeae strains from different regions of the russian Federation were examined. The results were evaluated according to the criteria such as CLSI (Clinical and Laboratory Standards Institution) and EUCAST (European Committee for Antimicrobial Susceptibility Testing). The results were processed by using the WHONET software, version 5.4. Results. According to the results of a study of N. gonorrhoeae antibiotic resistance, N. gonorrhoeae is highly resistant to penicillin (in 2010 - 72.4%, in 2011 - 50.6%, in 2012 - 51.2%, in 2013 - 49.3%), to tetracycline (in 2010 - 68.5%, in 2011 - 55%, in 2012 - 61.9%, in 2013 - 49.3%) and ciprofloxacin (in 2010 - 56.2%, in 2011 - 37.1%, in 2012 - 35%, in 2013 - 24.6%) for the entire observation period without any substantial trend towards its reduction. During studies of the resistance of the gonococcal infection pathogen to spectinomycin, the share of non-sensitive strains to the antibiotic reduced from 16.7% in 2010 to 0.7% in 2013. A slight reduction in the share of non-sensitive N. gonorrhoeae strains to azithromycin was also observed (in 2010 - 15.3%, in 2011 - 25.3%, in 2012 - 17.5%, in 2013 - 9.9%) yet these data substantially exceed the level recommended by the WHO for prescribing an antimicrobial therapy. A high level of N. gonorrhoeae sensitivity to ceftriaxone (100%) was revealed in 2010-2013. Conclusions. According to the analysis of resistance of N. gonorrhoeae strains to antimicrobial drugs found in the territory of the russian Federation in 2010-2013, there is a trend towards the reduction in the number of non-sensitive N. gonorrhoeae strains to penicillin, tetracycline, ciprofloxacin, spectinomycin and azithromycin, which can confirm the efficacy of the Neisseria gonorrhoeae antibiotic resistance monitoring measures taken by State research Center of Dermatovenereology and Cosmetology since 2002.
Neurosyphilis in HIV-infected patients
Authors: Krasnoselskikh T. V. , Sokolovskiy E. V.
Published: February 2022

A review article is addressed the issue of the diagnosis and treatment of neurosyphilis that is developing against the background of HIV-infection. HIV-infected patients are at higher risk of neurologic, ocular and auricular manifestation of syphilis as well as treatment failures and relapses. Diagnosis of neurosyphilis in HIV-positive patients is complicated because both infections cause similar changes in the cerebrospinal fluid (CSF). The effectiveness of neurosyphilis treatment in patients with HIV co-infection is difficult to estimate, since the normalization of their CSF goes slower comparing to HIV-negatives. The increase in incidence of syphilis and HIV co-infection is anticipated in the coming years. This necessitates a comprehensive study of the problem and requires the development of new approaches to neurosyphilis diagnosis and treatment in co-infected patients.
Russian register of patients suffering from chronic skin diseases
Authors: Kubanov A. A. , Almazova A. A. , Bogdanova YE. V.
Published: February 2022

The article provides a review of regulatory documents providing for the establishment of a universal governmental healthcare information system in the Russian Federation, describes the key goals and tasks for the register of patients with chronic skin disorders and characterizes different types of registries and their use.
Using platelet-enriched autologous plasma for treatment of non-scarring alopecias (androgenetic and circumscribed alopecia)
Authors: Mareyeva A. N. , Kondrakhina I. N. , Abuladze M. G.
Published: February 2022

The article presents literature data on the efficacy of using platelet-enriched autologous plasma for treatment of non-scarring alopecias (androgenetic and circumscribed alopecia).
The dynamics of some human skin biophysical parameters in the process of optical clearing after hyperosmotic solutions topical application
Authors: Utz S. R. , Tuchin V. V. , Galkina E. M.
Published: February 2022

Goal of the study. To study changes of certain biophysical parameters of human skin in the process of optical (immersion) clarification under the effect of hyperosmotic agents. Materials and methods. Measurements were made on the skin (on the right and left hands) of 18 female volunteers aged 17-38. Biophysical parameters of the skin and its phototype were determined with the use of Soft Plus, a device for the diagnostics of the skin condition (Callegari, Italy), and erythema melanin meter (EMM-002E, Russia). 30%, 40% and 50% aqueous glucose solutions as well as 50% aqueous-alcoholic (30°) fructose solution were used as hyperosmotic (dehydrating) study agents. Results. It was revealed that the extent and time of skin dehydration mostly depend on the method of application of the immersion agent and its composition. Depending on the applied technology, it is possible to achieve both a decrease and an increase in the skin moisture extent, which is related to the physiological response of the skin to the occlusion and osmotic action of the agents. 50% aqueous-alcoholic fructose solution appears to be the most efficient dehydrating agent of all study agents.
Androgenic hormone profile in patients with androgenetic alopecia
Authors: Konrakhina I. N. , Mareeva A. N. , Kalinina P. A. , Abuladze M. G.
Published: February 2022

In this article, the outcomes of the range of researches are described including the data on levels of testosterone, dihydrotestosterone, dehydroepiandrosterone sulfate, sex hormone-binding globulin and other components of androgen hormone profile in issues and biological fluids of males with androgenetic alopecia. Besides, in this article we describe results of recent studies devoted to effects of androgens on hair follicles and the role of 5-alpha reductase in conversion of androgens.
Morphometric efficacy evaluation of acne treatment with systemic isotretinoin in the form of LIDOSE
Authors: Abdukhalikova M. L. , Malova I. O.
Published: February 2022

Objective. Evaluation of changes of morphometric skin indicators of patients with moderate severity of acne in the course of treatment with systemic isotretinoin in the LIDOSE form. Materials and methods. 30 patients have been under study in the course of isotretinoin therapy ( LIDOSE form) with the dosage of 0.6-0.8 mg/kg per day till the course dose was reached 100-120 mg per kg of the body mass. Control group comprised 30 apparently healthy people. Results. The research conducted has revealed a high efficacy and tolerance of the therapy, and a valid positive tendency of changes in morphometric skin indicators has also been traced in the course of treatment. Conclusion. The conducted research has indicated that isotretinoin LIDOSE form has a positive effect on pathogenic mechanisms acne.
Experience of using tacrolimus as a part of a complex therapy of atopic dermatitis
Authors: Filimonkova N. N. , Kascheeva Y. V. , Kolbina M. S.
Published: February 2022

This review presents the results of international and Russian clinical studies conducted to assess the efficacy and safety of topical calcineurin inhibitors (TCIs) for the treatment of atopic dermatitis. The main mechanisms of action of TCIs are described. The authors demonstrate the advantages of Tacrolimus belonging to the TCI group. Due to the hydrophilic drug form and pharmacoeconomic index promoting compliance with treatment, it is possible to consider the new drug Tacropic (0.1% and 0.03% Tacrolimus ointments) as the optimum topical drug for the treatment of moderate to severe and severe forms of atopic dermatitis in adults and children.
Assessing the itching intensity using visual analogue scales in atopic dermatitis patients against the background of a therapy with calcineurin inhibitors
Authors: Chikin V. V. , Smolyannikova V. A. , Proshutinskaya D. V. , Nefedova M. A.
Published: February 2022

Goal. To assess the effect of topical treatment of atopic dermatitis patients with the 0.1% tacrolimus ointment on the itching intensity and skin expression level of growth factor proteins affecting the intensity of cutaneous innervation. Materials and methods. Fifteen patients suffering from atopic dermatitis underwent treatment with the 0.1% tacrolimus ointment. The SCORAD index was calculated to assess the severity of clinical manifestations. The itching intensity was assessed using a visual analogue scale. The skin expression of nerve growth factors, amphiregulin, semaphorin 3A and PGP9.5 protein (a nerve fiber marker) was assessed by the indirect immunofluorescence method. Results. An increased expression of the nerve growth factor and reduced semaphorin 3A expression levels were noted in the patients’ epidermis; there was an increase in the quantity, mean length and fluorescence intensity of PGP9.5+ nerve fibers. As a result of the treatment, the disease severity and itching intensity were reduced, the nerve growth factor expression level was reduced while semaphorin 3A expression level increased in the epidermis, and the mean length and fluorescence intensity of PGP9.5+ nerve fibers was also reduced. A positive correlation among the itching intensity and nerve growth factor expression level, quantity and mean length of PGP9.5+ nerve fibers in the epidermis was revealed, and negative correlation between the itching intensity and semaphorin 3A expression level in the epidermis was established. Conclusion. Topical treatment with the 0.1% Tacrolimus ointment reduces the itching intensity in atopic dermatitis patients, which is related to the therapy-mediated reduction in the epidermis innervation level, decreased expression of epidermal nerve growth factor and increased semaphorin 3A expression level.
Using standard serology blood tests to diagnose latent syphilis
Authors: Katunin G. L. , Rubtsov A. B.
Published: February 2022

Goal. To conduct a comparative assessment of the results of regulated serological tests obtained as a result of blood tests in patients suffering from latent syphilis. Materials and methods. The authors examined 187 patient medical records with newly diagnosed latent syphilis in FGBU GNTsDK (State Research Center for Dermatology, Venereology and Cosmetology), Health Ministry of the Russian Federation, in 2006-2015. The results of patient blood tests were analyzed with the use of non-treponemal (microprecipitation test/RPR) and treponemal (passive hemagglutination test, immune-enzyme assay (IgA, IgM, IgG), IFabs, immunofluorescence test and Treponema pallidum immobilization test) serology tests. Results. According to the results of blood tests of latent syphilis patients, the largest number of positive results was obtained as a result of treponemal serology tests such as immune-enzyme assay (100%), passive hemagglutination test (100%) and IFabs (100%). The greatest number of negative results was observed in non-treponemal (microprecipitation test/RPR) serology tests: in 136 (72.7%) patients; evidently positive results (4+) test results were obtained in 8 (4.3%) patients only. According to the results of a comparative analysis of blood tests in patients suffering from latent syphilis obtained with the use of treponemal serology tests, the greatest number of evidently positive results (4+) was noted for the passive hemagglutination test (67.9%). Negative treponemal test results were obtained with the use of the immunofluorescence test and Treponema pallidum immobilization test (21.9% and 11.8% of cases, respectively). Moreover, weakly positive results prevailed for the immunofluorescence test: in 65 (34.7%) patients. Conclusion. These data confirm that the following treponemal tests belong to the most reliable ones for revealing patients suffering from latent syphilis: immune-enzyme assay, passive hemagglutination test and IFabs.
Squamous-cell carcinoma in a female patient suffering from recessive dystrophic epidermolysis bullosa
Authors: Karamova A. E. , Chikin V. V. , Albanova V. I. , Smolyannikova V. A. , Nefedova M. A. , Monchakovskaya E. S.
Published: February 2022

The article describes a case of squamous-cell carcinoma in a female patient aged 30 suffering from a rare inherited disease -recessive dystrophic epidermolysis bullosa (RDEB). RDEB is characterized by a high risk of squamous cell carcinoma in young patients. The most frequent form is a highly differentiated form of cancer characterized by an aggressive course with the early development of metastases and fast progression, which is the most frequent cause of death in RDEB patients. The described case of squamous cell carcinoma in a young female RDEB patient emphasizes the role of early tumor diagnostics.
Lichen planus and associated psychosomatic disorders
Authors: Dorozhenok I. Yu. , Snarskaya E. S. , Shenberg V. G.
Published: February 2022

The urgency is due to a wide range of psychosomatic comorbidity lichen planus (LP). Objective: to determine the clinical relationships of the LP with comorbid psychosomatic disorders. The present prospective clinical study 93 (58 women, 35 men; middle age. 47, 6 years) of patients with LP predominantly dermal localization clinical-dermatological (using scales: the index of clinical symptoms -ICS and questionnaire dermatology quality of life index - DIQL), psychopathological, experimental-psychological, clinical and follow-up, statistical methods. Identified and clinically verified psychogenic manifestation of skin lesions in 28 (30.1%); nosogenic reactions (F43) 56 (60,2%); recurrent depression (F33) - in 9 (9.7%) cases. Defined clinical the relationship of various forms of the LP, the nature of the flow, severity, location and extent of the severity and structure of comorbid psychosomatic disorders.
Topical formulations used in the treatment of acne
Authors: Khairutdinov V. R. , Statsenco A. V. , Samtsov A. V.
Published: February 2022

The article presents 2 clinical observations of patients with papules-pustular form of acne of moderate severity. In both cases the use of combined topical therapy - topical clindamycin and azelaic acid. The therapeutic effect of clindamycin is faster than other topical preparations. Azelaic acid strengthens the anti-bacterial action of clindamycin, prevents the development of resistance. The results indicate the feasibility of the combined use of these drugs in the treatment of acne.
The complex therapy of acne rosacea with azelaic acid preparations
Authors: Gladko V. V. , Masyukova S. A. , Ilina I. V. , Sanakoyeva E. G. , Gorbakova E. V. , Zemlyakova S. S.
Published: February 2022

The present literature data on pathogenesis and treatment of acne rosacea are reported in the article. Research results on effectiveness of therapy with azelaic acid at patients with acne rosacea are presented. The nosotropically based standard of acne rosacea therapy is accepted in virtue of the world practice data.
RESULTS OF WORK OF DERMATOVENEREOLOGIC HEALTHCARE ORGANIZATIONS IN 2016
Authors: Kubanova A. A. , Kubanov A. A. , Melekhina L. E. , Bogdanova E. V.
Published: February 2022

The paper presents the analysis of incidence of sexually transmitted infections and skin disorders in Russian Federation in 2016, the work and resources of dermatovenereologic healthcare organizations.
CONGENITAL EPIDERMOLYSIS BULLOSA: PECULIARITIES OF EPIDERMIS REGENERATION AND METHODS OF TREATMENT
Authors: Kubanov А. A. , Karamova A. EH. , Al'banova V. I. , CHikin V. V. , Monchakovskaya E. S.
Published: February 2022

Congenital epidermolysis bullosa is a group of hereditary skin diseases caused by mutations in the genes of structural proteins of the dermoepidermal junction of the skin, characterized by formation of blisters and erosions at the smallest mechanical trauma. In patients with severe subtypes of borderline and dystrophic epidermolysis bullosa there are long-term erosive and ulcerative defects with disruption of the healing process. Factors that impede healing include: malnutrition, anemia, pain, inactivity, local factors (presence of infection, prolonged inflammation, extensive nature of the lesion, absence of skin appendages in the affected area, deficiency or lack of formation of type VII collagen). Elimination of healing impeding factors is the main challenge in treatment of severe subtypes of bullous epidermolysis. Modern promising treatment techniques are at the stage of development and have not yet been introduced into clinical practice, and, as of today, skin care and optimal topical treatment with modern non-adhesive dressings remain the most widespread treatment methods that facilitate accelerated healing.
BREACH OF SKIN BARRIER AS A LEADING FACTOR IN THE FORMATION OF LOCAL INFLAMMATORY PROCESS IN ATOPIC DERMATITIS.
Authors: Kudryavtseva A. V.
Published: February 2022

Atopic dermatitis (also known as infantile eczema, atopic eczema) is a chronic inflammatory skin disease, accompanied by intense itching and continuously relapsing eczematous lesions. Despite the fact that the disease most often begins in early childhood, it is also quite widespread among adults. The disease is often accompanied by a fairly severe psychoemotional stress in both patients and their families, increases the risk of seasonal allergic rhinitis and asthma. Pathogenesis of atopic dermatitis is based on an imbalance in the proliferation of T lymphocytes towards the proliferation of Type 2 T helper cells with a high IgE response to allergens penetrating into the deep layers of the skin. A significant role is attributed to the colonization of the affected skin with Staphylococcus aureus. At present time, the disease is deemed to be an incurable condition, in which the failure of the epidermal barrier is considered to be the leading cause of onset of the disease. Prevention of breaches of the skin barrier, treatment of exacerbations of immuno-mediated inflammation of the skin with corticosteroids along with calcineurin inhibitors in the second line of therapy, as well as control of Staphylococcus skin infections retain their relevance.
Analysis of the neurosyphilis incidence rate and quality oflaboratory diagnostics in the russian federation
Authors: Katunin G L , Frigo N V , Rotanov S V , Melekhina L E , Kitaeva N V , Lesnaya I N , Katunin G L , Frigo N V , Rotanov S V , Melekhina L Ye , Kitayeva N V , Lesnaya I N
Published: February 2022

According to the analysis of the state statistical reporting, the rate of new neurosyphilis cases was growing in the
Russian Federation in 1999-2009. Substantial differences in the number of detected neurosyphilis cases by different
federal districts were established. Low-quality laboratory diagnostics was proved to be one of the factors promoting the
neurosyphilis incidence rate. The quality of the neurosyphilis laboratory diagnostics was studied by means of
questionnaires distributed among dedicated dermatovenerological medical institutions. Substantial shortcomings in the
neurosyphilis laboratory diagnostics were established including absence of spinal fluid diagnostics in 17%-33% of the
institutions and inadequate compliance with the regulatory study methods (immunofluorescence test with whole spinal
fluid, microprecipitation test, cytosis and protein determination in the spinal fluid). For the purposes of optimizing the
neurosyphilis diagnostics in the Russian Federation, we suggest to provide for all-round and complex examination of
patients with suspected neurosyphilis based on the regulatory laboratory and functional diagnostics methods; it is also
required to make the spinal fluid examination based on the passive hemagglutination test being highly sensitive and
specific as well as having a high diagnostic efficacy for neurosyphilis a part of the standards aimed at rendering medical
aid to neurosyphilis patients.
Skin photoaging: current aspects
Authors: SNARSKAYA YE S
Published: February 2022

The author provides current data about mechanisms of the damaging effect of ultraviolet rays on our skin as well as describes constitutional skin phototypes (based on the Fitzpatrick scale) and clinical stages of skin photoaging (based on the Glogau classification system). The author assessed the extent of changes in the cell structure at different epithelial tumors of skin developing against the background of progressing skin photoaging. The study used molecular markers showing the extent of proliferative activity and differentiation of keratinocytes (anti-Ki67 antibodies, PCNA, P53, Bcl-2, matrix metalloproteinases MMP-1, -9 and their endogenous inhibitors Т1МР-1 ,-2) as their interpretation helps understand the processes of induction and promotion of oncogenesis induced by ultraviolet rays. The author also describes methods of photoaging prevention and treatment.
Genetic profile of psoriasis patients
Authors: Khayrutdinov V R , Khairutdinov V R
Published: February 2022

The article systematizes information about genetic polymorphisms associated with the risk of psoriasis and psoriatic
arthritis development. Gene variants that are potentially essential for their inclusion in genetic tests were sampled taking
into consideration polymorphism localization. The presented data are sufficient to prepare the genetic profile of psoriatic
patients, forecast the clinical course of the disease and potential efficacy of treatment, and calculate the risk of the
disease development in the patients relatives.
Etiology and clinical and epidemiological profile of erosive and ulcerative affections of genitals
Authors: Vasil'ev M M , Denisova V M , Vasiliyev M M , Denisova V M
Published: February 2022

The authors present data on clinical characteristics of the course of erosive and ulcerative affections on the skin of
genitals in patients who consulted a dermatovenerologist. The authors analyzed factors contributing to the onset of this
pathology and having an effect on the severity of its course. They also studied the composition of microbial associations
present in the discharge from lesion foci. The authors demonstrated the prevalence of a mixed infection as well as
opportunistic microflora in most patients suffering from erosive and ulcerative affections on the skin of genitals.
An investigation of the pharmacokinetics of topical Lamisil® 1% cream
Authors: Hill S , Thomas R , Smith S , Finlay A , Hill S , Thomas R , Smith S , Finlay A
Published: February 2022

Twenty volunteers were entered into a study to investigate the pharmacokinetics of Lamisil® 1% cream. The subjects were
randomized to receive Lamisil® 1% cream applied to the skin on the back on 1 day, or on 3, 5 or 7 consecutive days.
Up to five biopsies were taken at a site on the upper back at various time-points both during treatment and after
treatment. Lamisil® levels in the biopsies were analyzed using HPLC.
The study showed that increasing the number of applications from one to seven did not significantly increase the peak
concentration (Cmax) in the stratum corneum.
However, there was an increase in the total amount of Lamisil® found in the stratum corneum resulting in Lamisil® being
detected for longer periods after cessation of therapy.
Treatment for 7 days resulted in Lamisil® still being detectable 7 days after cessation of therapy, and the drug
concentration was significantly higher than the concentration killing the common causative organisms of superficial
dermatomycoses.
This study indicates a significant potential for short-term treatment with Lamisil® 1% cream in superficial
dermatomycoses.
Skin condition control in patients with chronic skin diseasesusing dermatic products
Authors: Sokolovskiy E V , Monakhov K N , Dombrovskaya D K , Sokolovsky Ye V , Monakhov K N , Dombrovskaya D K
Published: February 2022

Chronic skin diseases degrade the patients life quality. Presently, topical steroids are the most efficient drugs for the
treatment of inflammatory skin diseases. However, there is a risk involved in their application: the patient can develop
both systemic and topical adverse effects. As many as 37 patients with atopic dermatitis (including 16 pregnant women)
applied an advanced corticosteroid drug topically for two months (uniderm according to an intermittent regimen: for
two consecutive days with a time window of five days (twice a week) against the background of daily administration
of Emolium, a basic care product. The uniderm administration regimen made it possible to considerably improve the
patients skin condition in most of the cases and improve the life quality in patients with atopic dermatitis.
The roots of international dermatology
Authors: Kubanova A A , Samtsov A V , Zaslavskiy D V , Kubanova A A , Samtsov A V , Zaslavsky D V
Published: February 2022

This article gives historical overview of the development of international and European dermatovenereological societies.
The first European Dermatological Society and the first world Venereological Society open in Russia. Taking into
consideration the fact that it was the first officially registered national dermatological society whereas Municipal Society
of New York and American National Society were not registered by state authorities, the Russian Society is regarded
here as the first world official dermatological society. This article reviews the proffesional development of Prof Benjamin
Mikhialovitch Tarnowsky (1837-1906) the most significant dermatovenerologist, influenced the development of world
and Russian dermatovenerology, worked in the first world hospital specifically devoted to venereology, Kalinkinskaya
Hospital ( founded in 1750, Saint Petersburg).
Depicts XII International Congress, held in Moscow in August 7-14th, 1897, where the dermotology section was
represented by internationally recognized scientists. Among speakers Kaposi (Wien), Hallopeau (Paris), Gaucher (Paris),
Barthelemy(Paris), Wolf (Strassburg), Rosenthal (Berlin), Nikolsky (Kiev), Lindstrem (Kiev), Jullien (Paris), Poper-
Mor (Budapest), Schwimmer (Budapest), Pospelov (Moscow), Tarnowsky( Saint Petersburg); such sientists as Unna,
Campana, Lassar, Soffiantini, van Hoorn, Vatrashevsky, Yakovlev, Sack participated in the discussion.
Mixed urogenital infections: clinical and therapeutic approaches
Authors: Kondrat'eva Yu S , Neymark A I , Kondratiyeva Yu S , Neimark A I
Published: February 2022

The authors present the results of a study involving 80 patients suffering from inflammatory diseases of the urogenital
system caused by mixed pathogenic and opportunistic urinogenital infection. The patients underwent clinical and laboratory
examination; clinical characteristics of the course of the disease were recorded. The study results demonstrated clinical and
microbiological efficacy of Safocid, a combined drug used for treatment of this group of patients.
Up-to-date non-invasive visualization technologies in dermatology
Authors: Shtirshnayder Yu Yu , Michenko A V , Katunina O R , Zubarev A R , SHTIRSHNEIDER YU YU , MICHENKO A V , KATUNINA O R , ZUBAREV A R
Published: February 2022

The authors present a review of up-to-date non-invasive visualization methods used in diagnostics of diseases of skin and its appendages. They describe physical principles forming the basis for non-invasive visualization methods such as dermatoscopy, confocal laser scanning microscopy, optical video monitoring, optical topometry, optical coherent tomography, ultrasound scanning, 3D-modeling. They also describe the potential of practical application of these diagnostics methods at the current stage of their development. The authors have demonstrated that it is possible to reduce the clinicians need in biopsy diagnostics due to the high information value of non-invasive visual diagnostics methods.
Modern approaches and prospects of development of laboratory diagnostics for sexuallytransmitted infections
Authors: Kubanova A A , Frigo N V , Rotanov S V , Solomka V S , Plakhova K I , Rakhmatulina M R , Manuk'yan T E , KUBANOVA A A , FRIGO N V , ROTANOV S V , SOLOMKA V S , PLAKHOVA K I , RAKHMATULLINA M R , MANUKIAN T YE
Published: February 2022

The authors provide a comparison of modern approaches to the use of well-known laboratory methods for diagnostics of
syphilis, gonorrhea, trichomoniasis and urogenital clamidiosis, which are approved in the world science and practice.
They also examine promising directions in the development of up-to-date laboratory technologies (biomicrochips,
multiprimer PCR, mass spectrometry, PLEX-ID technology, immunoblotting, chemiluminescence immunoassay (CLIA),
xMAP, pyrosequencing) for detecting STD pathogens, which is necessary to make an etiological diagnosis and determine
efficient methods of treatment minimizing the period of time required for examination of patients.
Immunohistochemical analysis of molecular cell structures of genetic and adaptive immunityin patients suffering from psoriasis in the course of biological therapy
Authors: Katunina O R , KATUNINA O R
Published: February 2022

The author used the immunohistochemical method to study an effect of the biological modifier of immune reactions of
Infliximab on immunopathogenetic mechanisms directly in the affected skin of patients suffering from psoriasis.
The role of T-regulatory cells in the pathogenesis of psoriasis
Authors: Khayrutdinov V R , Mikhaylichenko A F , Mukhina M S , Samtsov A V , Imyanitov E N , Ivanov A M , KHAIRUTDINOV V R , MICHAILICHENCO A F , MUKHINA M A , SAMTSOV A V , IMYANITOV E N , IVANOV A M
Published: February 2022

T-regulatory cells control the strength and duration of immune response and play an important role in the pathogenesis of
psoriasis. The goal of the study was to examine the content of T-regulatory cells in peripheral blood and affected skin of
psoriasis patients, the level of FOXP3 mRNA expression in psoriatic skin. Determination of subpopulations of T-regulatory
lymphocytes in peripheral blood was performed using flow cytometry. The median level of FOXP3 mRNA expression was
determined in biopsies of the skin by PCR in real time. Immunohistochemistry was performed with monoclonal anti-
FOXP3 antibodies. Revealed an increase in the relative content of T-regulatory cells in the peripheral blood of patients with
psoriasis in the progressive period, compared with healthy people. The level of FOXP3 mRNA expression in psoriatic foci
was 3.1 times higher than in healthy individuals. Was noted a 10-fold increase in the number of T-regulatory lymphocytes
in the skin of psoriasis patients in the progressive period, compared with skin from healthy donors.
Assessment of the BRAF status in patients with skin melanoma
Authors: Gyrylova S N , Ruksha T G , Zobova S N , Komina A V , Aksenenko M B , GYRYLOVA S N , RUKSHA T G , ZOBOVA S N , KOMINA A V , AKSENENKO M B
Published: February 2022

Skin melanoma is an aggressive malignant neoplasm. Mutation of the BRAF gene, BRAF V600E, is observed in more than
70% of melanoma cases. Assessment of the BRAF status in patients suffering from skin melanoma is an important stage
in patient screening for selection of further therapy.
To reveal the mutation of BRAF V600E, 27 histology samples taken from patients with skin melanoma residing in the
Krasnodar territory were examined by means of defining the Restriction Fragment Length Polymorphism (PFLP assay).
Our studies revealed the BRAF V600E mutation in 26 of 27 histology samples of skin melanoma. It was shown that the
mutation is not associated with any sex-related, age-related, clinical and pathological features of the tumor.
Lechenie «dermatita otmeny» posleprimeneniya topicheskikh glyukokortikosteroidovs ispol'zovaniem aktivirovannogo tsinkapiritiona
Authors: Perlamutrov Yu N , Ol'khovskaya K B , PERLAMUTROV YU N , OLKHOVSKAYA K B
Published: February 2022

The authors present the results of a study of efficiency of Skin-Cap in treatment of withdrawal dermatitis after application
of topical glucocorticosteroids.
The study involved 46 patients who had topical corticosteroids applied on their face skin in the anamnesis, who were
divided into two groups depending on the therapy. The efficiency of treatment was assessed based on the dynamics of the
Dermatological Index of Symptom Scale (DISS).
A comparative assessment of the efficiency of treatment with the use of the Skin-Cup cream and non-specific antiinflammatory
drugs showed the highest efficiency of application of activated zinc pyrithione, which was became apparent in
reliably more intensive reduction of the DISS and certain subjective and objective symptoms of the inflammatory reaction.
Good results of the study substantiate the expediency of administration of Skin-Cap in treatment of patients with
symptoms of withdrawal dermatitis as this drug facilitates the course of the disease and results in faster elimination of
the inflammation. Application of the cream containing activated zinc pyrithione makes it possible to avoid administration
of system drugs.
Clinical efficiency of the Demoten gel for complex treatment and prevention of demodectic mangeand rosacea
Authors: Sirmays N S , Ustinov M V , SIRMAIS N S , USTINOV M V
Published: February 2022

The assessment of the efficiency of different treatment methods and effect of the Demoten gel on the monotherapy and
complex treatment of rosacea and demodectic mange was conducted based on the dynamics of indices for both clinical
picture and subjective sensations. The study involved 57 patients. It was shown that the Demoten gel used in a complex
therapy of demodectic mange and papulopustular rosacea can reduce the drug treatment period, prolong the positive
effect of treatment and extend the remission period when the gel is used for prevention purposes.
Skin melanoma: from systematic biology to the personalized therapy
Authors: Ruksha T G , Aksenenko M B , Sergeyeva Ye Yu , Fefelova Yu A
Published: February 2022

Systematic biology is a new field of biomedicine based on the integrative approach to molecular mechanisms of the operation of living systems including in case of the development of pathological processes. In this connection, up-to-date therapeutic approaches to skin melanoma treatment can be considered on the basis of key changes in intermolecular interactions taking place during tumor development.