bluuebunny/crossref_metadata_2025 huggingface dataset:
The role of the genes of the enzymes of free radical and toxic compounds metabolism in aging and longevity
Authors: Эрдман В.В. , Насибуллин Т.Р. , Туктарова И.А. , Викторова Т.В. , Матуа А.З. , Мустафина О.Е.
Published: November 2020

В связи увеличением числа лиц преклонного возраста в структуре населения развитых стран особенную актуальность приобретает идентификация биологических и средовых факторов, способствующих сохранению физической и умственной активности людей данной возрастной группы. На выборке 767 башкир в возрасте от 1 до 105 лет, жителей Республики Башкортостан, методом ПЦР проведен анализ ассоциаций полиморфных локусов семи генов, кодирующих ферменты метаболизма токсичных соединений и свободных радикалов, с возрастом. В старческой группе частота аллеля MSRA*C выше относительно таковой среди лиц в возрасте 1-60 лет (p=0,036); шансы достижения старческого возраста повышаются у носителей генотипа MSRA*C/C в возрастном диапазоне 28-75 лет (OR=1,048, p=0,038). Выявлено снижение шансов обнаружения генотипа САТ*C/C в возрастном диапазоне до 70 лет (OR=0,979, p=0,028). Генотип NAT2*G/G среди долгожителей встречается с большей частотой, чем в группе лиц среднего возраста (p=0,04). Частота аллеля SOD1*А и генотипа SOD1*А/А выше среди долгожителей в сравнении с лицами старческого возраста (p=0,05). Полиморфные локусы генов SOD1, CAT, MSRA и NAT2 можно рассматривать как потенциальные фармакогенетические маркеры при выборе терапии у лиц старческого возраста.

Owing to the increase of the number of elderly people among the population of the developed countries, the identification of biological and environmental factors contributing to the preservation of their physical and mental activity is of great importance. On the sample of 767 Bashkirs aged from 1 to 105 years old, residents of the Republic of Bashkortostan, the analysis of associations between polymorphic loci of seven genes of the enzymes of free radical and toxic compounds metabolism and the age was performed using PCR method. The frequency of the MSRA*C allele is higher in the group of aging people than in the group of the people aged 1-60 years (p=0,036); the chances of reaching the senile age are increased among carriers of the MSRA*C/C genotype in the age range of 28-75 years (OR=1,048, p=0,038). A decrease of the chances of detecting the CAT*C/C genotype was revealed in the age range up to 70 years (OR=0,979, p=0,028). The NAT2*G/G genotype occurs with a higher frequency among centenarians than in the group of middle-aged people (p=0,04). The frequencies of the SOD1*A allele and the SOD1*A/A genotype are higher among centenarians compared with people of senile age (p=0,05). Polymorphic loci of the SOD1, CAT, MSRA and NAT2 genes can be considered as potential pharmacogenetic markers in the choice of therapy for elderly people.
Regular genetic counseling and DNA diagnostics of hereditary diseases of the cardiovascular system in the practice of the federal multidisciplinary surgical center (the analysis of the experience of last 10 years work experience of medical genetics laboratory of Petrovsky National Research Centre of Surgery)
Authors: Румянцева В.А. , Заклязьминская Е.В.
Published: November 2020

Анализ результатов 10-летней работы лаборатории медицинской генетики показал необходимость развития новых отраслей генетики для формирования персонализированной медицины в России. Совершенствование медико-генетической службы на базе многопрофильного хирургического центра дает большие преимущества в развитии семейных обследований.

The analysis of last 10 years work experience of medical genetics laboratory has shown the need for the development of new branches of genetics for the formation of personalized medicine in Russia. The improvement of the medical genetic services at the multidisciplinary surgical center provides great advantages in the development of family examinations.
Identification of a mutation in the polycystin 1 gene in a patient with intracranial aneurysm
Authors: Султанова Р.И. , Хуснутдинова Э.К. , Хусаинова Р.И.
Published: November 2020

Интракраниальная аневризма - заболевание соединительной ткани многофакторной природы, приводящее к спонтанным субарахноидальным кровоизлияниям. Обнаружено ранее неописанное изменение нуклеотидной последовательности гена PKD1 в гетерозиготном состоянии c.6847G>A с патогенной значимостью у пациентки с субарахноидальным кровоизлиянием.

Intracranial aneurysm is a multifactorial connective tissue disease leading to spontaneous subarachnoid hemorrhages. It was identified undescribed heterozygous nucleotide sequence change of the PKD1 gene c.6847G>A in patient with subarachnoid hemorrhage with pathogenic significance.
MicroRNA-binding site polymorphisms and risk of breast cancer
Authors: Бермишева М.А. , Гилязова И.Р. , Зиннатуллина Г.Ф. , Богданова А.А. , Хуснутдинова Э.К.
Published: November 2020

Рак молочной железы (РМЖ) - многофакторное, генетически гетерогенное заболевание. Результаты многочисленных исследований доказали важную роль микроРНК в прогрессии опухолей. Гены микроРНК являются высоко консервативными, и считается, что любые варианты в этих последовательностях, а также сайтах связывания микроРНК в генах-мишенях находятся под отрицательным селективным давлением. Предполагается, что такие изменения могут быть связаны с повышенным риском развития рака. Наше исследование направлено на выявление генетических вариантов в сайтах связывания микроРНК с мишенью, ассоциированных с риском развития РМЖ. Проведен анализ полиморфных вариантов, расположенных в 3’- нетранслируемых регионах генов BRCA1, BRCA2, BRIP1, RAD51, RAD52, MRE11A, NBN, ERBB4, PTEN у больных РМЖ и в группе контроля. Определено, что полиморфные варианты rs11895168/ERBB4 и rs7180135/RAD51 ассоциированы с риском развития РМЖ.

Breast cancer (BC) is a complex, genetically heterogeneous disease. The results of numerous studies have proven the important role of miRNA in tumor progression. miRNA sequences are highly conserved. Any variants in these sequences as well as the binding sites of miRNA in the target genes are supposed to be under negative selective pressure. miRNA that alter the expression of genes have been identified to play a significant role in BC regulation. The present study is aimed at investigating the involvement of SNPs in miRNA-binding sites as risk factors for the development of BC. A case - control study was performed to evaluate genetic variants of BRCA1, BRCA2, BRIP1, RAD51, RAD52, MRE11A, NBN, ERBB4, PTEN genes as BC risk factors. The results of the present study suggest that genetic variants rs11895168 / ERBB4 and rs7180135 / RAD51 are associated with breast cancer risk.
DNA methylation of the dihydropyrimidinase DPYS gene promoter in breast tumors with different response to neoadjuvant chemotherapy
Authors: Стрельников В.В. , Сигин В.О. , Калинкин А.И. , Литвяков Н.В. , Снеговой А.В. , Кононенко И.Б. , Цыганов М.М. , Ибрагимова М.К. , Залетаев Д.В. , Танас А.С.
Published: November 2020

По результатам широкогеномного исследования нами обнаружено аномальное метилирование промотора гена дигидропиримидиназы DPYS в образцах рака молочной железы (РМЖ). Поскольку дигидропиримидиназа вовлечена в катаболизм антагонистов пиримидинов, представляет интерес роль метилирования DPYS в определении чувствительности опухолей к препаратам этой группы. Детальный анализ состояния метилирования DPYS в 29 образцах биопсий РМЖ люминального В подтипа, полученных до неоадъювантной химиотерапии (НАХТ) с использованием антагонистов пиримидинов, показал, что опухоли с метилированным промотором DPYS более чувствительны к НАХТ, чем с неметилированным промотором (площадь под ROC-кривой AUC=0,87). Результаты указывают на целесообразность включения антагонистов пиримидинов в схемы НАХТ РМЖ люминального В подтипа тем пациенткам, в биопсийном материале опухолей которых, взятых до лечения, определяется гиперметилированное состояние промотора гена DPYS.

Within a genome-wide study, we have identified abnormal methylation of the dihydropyrimidinase DPYS gene promoter in breast cancer (BC). Since dihydropyrimidinase is involved in the catabolism of pyrimidine antagonists, the role of DPYS methylation in determining the sensitivity of tumors to such drugs is of interest. Detailed analysis of DPYS methylation in 29 biopsy samples of the LumB BC subtype obtained before neoadjuvant chemotherapy (NACT) with pyrimidine antagonists discovered that tumors with methylated DPYS promoter are more sensitive to NACT than tumors with unmethylated DPYS (AUC=0.87). Our results indicate the advisability of including pyrimidine antagonists in the LumB BC NACT regimens for patients whose tumor biopsy samples taken before treatment demonstrate hypermethylation of the DPYS promoter.
Frequency of pathogenic variants in BRCA1 and BRCA2 genes in a population-based sample and in patients with breast or ovarian cancer
Authors: Лимонова А.С. , Мешков А.Н. , Ершова А.И. , Киселева А.В. , Скирко О.П. , Климушина М.В. , Сотникова Е.А. , Курилова О.В. , Ефимова И.А. , Любченко Л.Н. , Филиппова М.Г. , Полозников А.А. , Куценко В.А. , Покровская М.С. , Драпкина О.М.
Published: November 2020

Развитие молекулярно-генетических исследований позволило определить мутации в генах BRCA1 и BRCA2, приводящие к возникновению наследственных форм рака молочной железы (РМЖ) и рака яичников (РЯ). Проведение генетического тестирования открывает возможности осуществления ранней диагностики и направленной профилактики. Цель: сравнить распространенность патогенных вариантов в гене BRCA1 и BRCA2 у больных с верифицированным РМЖ/РЯ и в популяционной выборке женщин без онкологических заболеваний. Было включено 156 больных с диагнозом РМЖ/РЯ и 359 женщин без онкологических заболеваний из популяционной выборки ЭССЕ-Вологда. Для генетического анализа использована диагностическая панель, разработанная в ФГБУ «НМИЦ ТПМ», позволяющая выявлять варианты генов BRCA1 и BRCA2. Среди обследованных больных выявлено 5 носителей (3,21%) мутаций в гене BRCA1 (у 4 человек - rs80357906, 2,56%; у 1 человека - rs80357711, 0,64%) и 1 носитель (0,64%) rs80359550 в гене BRCA2. В выборке женщин без онкологических заболеваний носителей не выявлено. При наличии вариантов BRCA1 (rs80357906, rs80357711) или BRCA2 (rs80359550) риск развития РМЖ/РЯ повышен как минимум в 2,63 раза (р=0,0009). Выявление патогенных вариантов генов BRCA1 и BRCA2 может способствовать ранней диагностике и своевременной профилактике РМЖ и РЯ.

Progress in genetics and molecular research enabled discovery of mutations in BRCA1 and BRCA2, leading to the development of hereditary breast (BC) and ovarian (OC) cancer. Genetic testing contributes to early diagnosis and targeted prevention of these cancers. Objective: To investigate the prevalence of pathogenic variants in BRCA1 and BRCA2 genes in patients with BC/OC and in a population-based sample without oncological diseases. Methods: 156 patients with diagnosed BC/OC were included in the study consecutively. In addition to it, 359 women from a population-based sample ESSE-Vologda were recruited in the study. Variants of BRCA1 and BRCA2 were detected using a custom panel. Results: Among cancer patients there were 5 carriers (3.21%) of mutations in BRCA1 (4 - rs80357906, 2.56%; 1 - rs80357711, 0.64%) and 1 carrier (0.64%) of rs80359550 in BRCA2. In a population-based sample no mutations were identified. The presence of BRCA1 (rs80357906, rs80357711) or BRCA2 (rs80359550) variants increases the risk of BC/OC at least 2.63 times (р=0.0009). Conclusion: Detection of pathogenic variants in BRCA1 and BRCA2 could facilitate early diagnosis and timely prevention of BC and OC.
On the hypothesis of an association between ABCC11 polymorphism and breast cancer. Ethnic aspect
Authors: Макаров С.В. , Карапетян М.К.
Published: November 2020

Для проверки гипотезы об ассоциации полиморфизма 538G>A ABCC11 и рака молочной железы (РМЖ) проведено сравнительное исследование выборок больных и контроля европеоидных женщин РФ - страны с высокой смертностью. Полученные данные не подтверждают гипотезу о повышенном риске РМЖ у носителей ABCC11*538G.

To test the hypothesis about an association between ABCC11 538G>A polymorphism and breast cancer we analysed the frequency of this functional SNP in case-control breast cancer study of Caucasian women from Russia (one of top-ten mortality rate countries) but found no evidence for increased breast cancer risk.
LIG1 and LIG3 repair gene polymorphisms and the risk of developing breast and ovarian cancer
Authors: Бисултанова З.И. , Джамбетова П.М.
Published: November 2020

В выборке из 409 женщин с раком молочной железы и 60 с раком яичников из Чеченской республики исследованы ассоциации четырех функционально значимых полиморфизмов генов LIG1 и LIG3 (rs156641, rs20579, rs1052536, rs4796030) с заболеваниями. Генотипирование выполнено методом ПЦР-анализа. Выявлены кандидатные генотипы, которые влияют на риск развития рака молочной железы и рака яичников.

The nature of the effect on the formation of breast cancer and the reproductive system in 409 women with breast cancer and 60 with cancer in the Chechen population of four functionally significant polymorphisms of the LIG1 and LIG3 genes (rs156641, rs20579, rs1052536, rs4796030) was studied. Genotyping was performed using PCR analysis. We identified the candidate genotypes that influence the risk of developing breast and ovarian cancer.
Expression levels of immune control points genes in renal cell carcinoma
Authors: Апанович Н.В. , Алимов А.А. , Апанович П.В. , Кузеванова А.Ю. , Мансорунов Д.Ж. , Карпухин А.В.
Published: November 2020

Внедрение в терапию рака новых препаратов на основе ингибирования иммунных контрольных точек (ИКТ) существенно улучшило прогноз для больных. Тем не менее, такая терапия не всегда эффективна. Для вскрытия возможных причин этого мы изучили уровни экспрессии PD-L1 и других генов ИКТ - IDO1, CEACAM1, PVR, TDO2, CD276, GAL9 и ADAM17 в образцах светлоклеточного почечно-клеточного рака. В результате анализа выявили наиболее часто экспрессирующиеся совместно с PD-L1 гены - IDO1, TDO2, CD276, GAL9 и ADAM17. Значимую корреляцию с экспрессией PD-L1 имела экспрессия генов ADAM17, PVR и CD276. Полученные данные могут иметь значение для дальнейшего развития терапии на основе блокирования ИКТ, включая PD-L1.

The introduction of new drugs based on the inhibition of immune control points (ICР) into cancer therapy has significantly improved the prognosis for patients. However, such therapy is not always effective. To reveal the possible reasons for this, we studied the expression levels of PD-L1 and other ICР genes - IDO1, CEACAM1, PVR, TDO2, CD276, GAL9 and ADAM17 in samples of clear cell renal cell carcinoma. The analysis revealed the genes most often expressed together with PD-L1 - IDO1, TDO2, CD276, GAL9 and ADAM17. Significant correlation with the expression of PD-L1 was found for the expression of ADAM17, PVR, and CD276 genes. The data obtained may be important for the further development of therapy based on blocking ICP, including PD-L1.
Improved Description of Charge Transfer Potential Energy Surfaces via Spin-Component Scaled CC2 and ADC(2) Methods
Authors: Tajti Attila , Kozma Balázs , Szalay Péter
Published: November 2020

The performance of spin-component scaled variants of the popular CC2 and ADC(2) methods is evaluated for CT states, following benchmark strategies of earlier studies. The results show the capability of spin-component scaled approaches to reduce the large errors of their regular counterparts to a significant extent.
Unknown Knowns: Case Studies in Uncertainties in the Computation of Thermochemical Parameters
Authors: Simmie John
Published: November 2020

Both the computation of, and the uncertainties associated, with gas-phase molar formation enthalpies are now quite well established for systems comprised of tens of ‘heavy’ atoms chosen from the commonest elements. The same cannot be said for derived thermochemical quantities such as entropy, heat capacity and an enthalpy function. Whilst the application of well known statistical thermodynamic relations is mostly understood, the determination of the uncertainty with which such values can be obtained has been little studied — apart, that is, for a general protocol devised by Goldsmith et al. [J. Phys. Chem. A, 2012, 116, 9033–9057]. Specific examples from that work are explored here and it is shown that their estimates are overly pessimistic. It is also evident that for some species the calculated thermochemical parameters show very little variation with either the level of theory, or basis set, or treatment of vibrational modes — this renders the inclusion of such species in databases designed to validate new methods of limited value.
Photoelectrocatalytic Cross-Dehydrogenative Coupling of Unactivated Aliphatic Hydrogen Donors with Benzothiazoles: Synthetic Applications and Mechanistic Insights
Authors: Capaldo Luca , Quadri Lorenzo L. , Merli Daniele , Ravelli Davide
Published: November 2020

We report herein a photoelectrocatalytic strategy for the smooth preparation of 2-alkylbenzothiazoles via the cross-dehydrogenative coupling of unactivated aliphatic hydrogen donors (e.g. alkanes) with benzothiazoles. We used tetrabutylammonium decatungstate (TBADT) as the photocatalyst to cleave the strong C(sp3)-H bonds embedded in the chosen substrates via Hydrogen Atom Transfer (HAT), while electrochemistry ensured the success of this net-oxidative transformation by scavenging the extra electrons. The reaction progress was monitored through kinetic analysis, highlighting the transient formation of the redox-neutral adduct 2-alkylbenzothiazoline. Further cyclic voltammetry and laser flash photolysis experiments unveiled the chameleonic behavior of TBADT that features a three-fold role: HAT photocatalyst to activate alkanes, photoredox catalyst to activate the 2-alkylbenzothiazoline and electrocatalyst to promote the oxidation of short-lived radical intermediates. The adopted potentiostatic mode allowed to tame the multi-faceted reactivity of TBADT and to ensure its recovery after each catalytic cycle with a very high faradaic efficiency. We proved the versatility of the proposed approach by replacing the potentiostat with a couple of cheap batteries in the preparation of the desired products.
Melt-Polymerization of Acrylamide Initiated by Nucleophiles: A Route Towards Highly Branched and Amorphous Polyamide 3
Authors: Edinger David , Weber Hansjörg , Žagar Ema , Pahovnik David , Slugovc Christian
Published: November 2020

The melt-polymerization of acrylamide initiated by nucleophiles allows for the preparation of polyamide 3 (PA 3) with a branching factor of about 1.5. The high share of branching units imparts a fully amorphous morphology featuring a low glass transition temperature of 67 °C and renders the polymer water soluble. The disclosed method provides an easy, resource-efficient and green access to a polymer interesting for applications in biological and biomedical systems. The obtained PA 3 was characterized by several NMR-techniques, MALDI-TOF mass spectrometry, size-exclusion chromatography, thermal analyses and powder-X-ray diffractometry. Preparation and characterization of a 15N-marked polymer complemented the elucidation of the polymers structure. Mechanistically, the polymerization can be considered as an aza-Michael polymerization of acrylamide involving zwitter-ionic species as the key intermediates being responsible for the high degree of branching.
Highly Chemoselective Synthesis of Hindered Amides via Cobalt-Catalyzed Intermolecular Oxidative Hydroamidation
Authors: Yin Yun-Nian , Ding Rui-Qi , Ouyang Dong-Chen , Zhang Qing , Zhu Rong
Published: November 2020

α-Tertiary amides are of great importance for medicinal chemistry. However, they are often challenging to access through conventional methods due to reactivity and chemoselectivity issues. Here we report a single-step approach towards such amides via cobalt-catalyzed intermolecular oxidative hydroamidation of unactivated alkenes, using nitriles of either solvent- or reagent-quantities. This protocol is orthogonal to groups that rapidly react under known carbocation amidation conditions such as tertiary alcohols, electron-rich alkenes, ketals, weak C−H bonds, and carboxylic acids. Straightforward access to a diverse array of hindered amides is demonstrated, including a rapid synthesis of an aminoadamantane-derived pharmaceutical intermediate.
Capacidad jurídica en el nuevo artículo 3 del Código Civil
Authors: Torres Vásquez Aníbal
Published: November 2020

En el presente artículo, el autor realiza un profundo análisis sobre el tratamiento jurídico que el Derecho ha otorgado al ser humano para ser titular de derechos y deberes. Sostiene que el ordenamiento jurídico al estar encargado de reconocer los derechos de las personas, puede limitar o privar determinados derechos para salvaguardar una coexistencia social civil pacífica. Asimismo, establece el autor que, al ser nuestro país parte de la Convención sobre los Derechos de la Personas con Discapacidad y en aras de construir una sociedad justa y respetuosa, es esencial que el Estado garantice las adaptaciones legales y políticas necesarias para que las personas con discapacidad puedan realizarse como personas con plenos derechos.
Antipyretic Activity of the Root Extracts of Xylocarpus
Authors: Ganesh Kumar Y  , Pranitha D  , Phaneendra D  , Madhava Reddy Ch
Published: November 2020

Various types of conditions exist in the body that causes fever and pain. Drugs that are used to treat fever are called antipyretics, and those are usually prescribed to treat elevated body temperature. But those drugs result in many other side effects like ulcers, perforations, bleedings and obstructions, which make their use questionable and limiting. Medicinal plants are used in the treatment of diseases from the starting of the human race and the process; they had been subjected to rigorous investigations and tests to establish a scientific proof and validation of the various pharmacological activities and their respective mechanisms of action in treating the herbs. Considering the anti-inflammatory properties of the plant, Xylocarpus mekongesis was investigated for its antipyretic activity in yeast method and 3doses out of which 00mg/kg body weight showed a better activity compared to the standard drug and other extracts too. The mechanism of action was similar to the paracetamol action that is inhibition of prostaglandin synthesis.
Effect of coronavirus disease in patients with kidney disease in India
Authors: Shashi Prabha Singh  , Preeti Sharma  , Durgesh singh  , Pradeep kumar  , Rakesh Sharma  , Rachana Sharma
Published: November 2020

Coronavirus disease 19 is a global pandemic which infects over millions of people worldwide in a limited time and changes the lifestyle, clinical spectrum lies from asymptomatic infection to pneumonitis with cardiorespiratory failure and finally death. Higher mortality occurs in senior and who are suffering from co-morbidities like chronic kidney disease, (HTN) hypertension, (DM TYPE II) diabetes mellitus or (CVD) cardiovascular diseases. However, rather than normal individuals, patients with chronic kidney disease (CKD) are under higher risk for infections. The chronic systemic inflammatory state is a significant cause for morbidity and mortality in CKD patients. The objective of this review is to discuss the pathogenesis of COVID-19 in CKD, changes observed in the immune system of CKD patients, COVID-19 infections risk in CKD and therapeutic approach of COVID-19 in CKD patients. From the standpoint of frequent renal co-morbidities in covid19 patients, renal complications were explored in covid19 patients received at level 2 tertiary care Santosh Hospital, Ghaziabad, U.P. Delhi-NCR India during March to August 2020 as per the protocol of Nephrology Society of India. Relevant clinical trials were reviewed in support. Meta-analysis and clinical trials are covered in this review study. Duplicate studies are not taken into account. The outcome of the studies shows that CKD patients are more prone to COVID-19. CKD patients are more likely infected with COVID-19 virus. Whereas in intensive care, CKD occurs more frequent than DM type II and CVD. So,COVID-19 pathogenesis in CKD patients, risk of COVID-19, immunologic changes and therapy COVID-19 in CKD can add support in the effective management of COVID-19.
大数据时代会计信息化风险与防范研究
Authors: 陈 羽舒
Published: November 2020

在当今的数据时代，伴随着互联网在各行各业的广泛应用以及通信技术的迅猛发展，科技已经彻底地改变了人们的生活。大数据技术的出现，既为企业的会计改革与创新带来了难得的发展机遇，同时也对企业的财务管理带来了全新的挑战。会计作为企业管理工具之一，也同样面临着信息化发展过程中的各种风险和挑战。论文以大数据时代会计信息化为研究对象,采用文献综述法、总结归纳法等方法，对大数据环境下企业的会计信息化发展中的风险进行系统研究。通过列举企业财务信息化管理中的风险并分析其成因,提出大数据时代会计信息化风险的防范对策，即健全会计行业相关的法律法规、完善会计信息化平台体系的建设、提高会计队伍的专业化水平、强化会计信息化的风险监督等。通过对大数据时代会计信息化发展中存在的风险的分析，可为企业会计信息的安全管理提供帮助；并有助于提高现代企业的整体管理水平，提高生产经营的效率，降低管理成本，从而为企业的管理决策提供有利支持。
数字经济下管理会计人才培养策略研究
Authors: 周 园 , 张 馨予 , 梁 毕明
Published: November 2020

数字经济的飞速发展给管理会计人才培养带来了契机和挑战。在此背景下，论文对管理会计人才培养的具体路径进行了分析，对数字经济下管理会计的内涵进行了界定，在此基础上，对数字经济下高校管理会计人才培养的目标、知识体系及课程体系、人才培养模式和教学资源开发等方面进行了探讨，以期培养出具备数字经济下企业管理信息识别、分析、处理和报告能力的、能促进企业价值创造的管理会计高端人才。
新发展理念下推进“旅游兴疆”发展战略
Authors: 古拉依夏 哈孜哈克
Published: November 2020

新发展理念就是坚持一种创新、协调、绿色、发展和共享的发展方式。深刻认识及把握新发展理念，对中国新疆旅游业的可持续发展具有战略意义。
浅析突发公共事件下的家庭理财
Authors: 邓 芳艳 , 康 海燕
Published: November 2020

随着家庭收入和财富的增长以及中世界经济环境的不稳定，家庭理财的行为受到了极大影响，如何管理好家庭经济，关系到家庭能否过好日子。然而，突发公共事件背景下，家庭理财该如何调整、应对。论文较为深入地分析了突发公共事件对居民家庭支出结构的影响，并结合当前经济形势，提出了家庭理财的对策建议。
浅议新常态下的卷烟市场营销策略调整
Authors: 邵 向前
Published: November 2020

随着中国经济逐渐步入新常态，烟草行业市场格局也已经基本形成。在新常态下，卷烟如何调整市场营销策略，获得更高的市场份额是当前卷烟企业需要重点关注的内容。论文针对新常态下卷烟市场营销所面临的问题以及挑战进行探究，指出卷烟市场营销策略调整的相关方法，希望能为卷烟市场营销活动的顺利稳定开展提供一定的参考。
分析商誉减值测试方法及会计处理的理性思考
Authors: 刁 莉
Published: November 2020

随着近几年中国市场经济体系不断进步，中国各企业的发展也呈现出了向好向上的发展趋势，但是在企业发展过程中商誉问题却成为社会各界高度重视的一个问题。因为商誉问题涉及很多层面，并且商誉所涉及的资金量也十分庞大，所以各企业在发展过程中就要重视商誉计量方式。中国有关部门为了解决这一问题，在社会发展过程中就颁布了新会计准则来规范商誉计量方式。论文针对当前形势下的商誉减值测试方法与会计处理问题进行论述，希望企业发展带来帮助。
大数据视域下管理会计在企业中的实践探究
Authors: 陈 连杰
Published: November 2020

在当前的时代背景下，社会生活诸多方面已经融入了大数据，大数据技术也成为推动时代向前进步以及发展的重要力量。大数据为管理会计发展提供了源源不断的动力，也促使管理会计在工作成效方面得到进一步提高。论文主要针对大数据视域之下管理会计在企业中的实践进行探讨，以供相关专业人士进行参考和借鉴。
医疗器械上市许可持有人不良事件监测和再评价合规管理
Authors: 许 慧 , 康 瑞
Published: November 2020

目前，作为核心安全主体责任人的医疗器械上市许可持有人并未能重视依规履职，对不良事件监测缺乏必要的重视。业界尚存在对不良事件监测的认识误区，存在对不良事件范围的误判。随着上市许可持有人全生命周期责任体系的不断完善和相关监管政策导向，许可持有人对不良事件监测合规必须引起重视，否则将出现无法应对的监管风险。2020年7月28日，中华人民共和国国家药品监督管理局出台了《关于进一步加强药品不良反应监测评价体系和能力建设的意见》（国药监药管〔2020〕20号），对进一步加强药品不良反应监测评价体系和能力建设提出系统化的意见，强调指导和督促持有人落实药品安全主体责任。按照《医疗器械监督管理条例》和《医疗器械不良事件监测和再评价管理办法》（以下简称《办法》）的要求，医疗器械上市许可持有人(以下简称持有人)应当具有保证医疗器械安全有效的质量管理能力和相应责任能力，建立医疗器械不良事件监测体系，向医疗器械不良事件监测技术机构(以下简称监测机构)直接报告医疗器械不良事件。由持有人授权销售的经营企业、医疗器械使用单位应当向持有人和监测机构报告医疗器械不良事件。
超级连接的博物馆——网站建设、APP 系统设计解析
Authors: 陈 睿
Published: November 2020

随着现代科技的日新月异，信息时代给博物馆带来新的机遇。对于实体博物馆来说，数字博物馆是利用信息时代的诸多优势作为博物馆有益的、必要的补充。数字博物馆是建立在网络上的虚拟博物馆，数字博物馆与博物馆的网络化、信息化有着密切联系。数字博物馆既是传统博物馆面向新世纪、适应信息时代发展要求的产物，也是现代博物馆发展的必然。
信息化环境下中职院校信息化教学综合探索
Authors: 焦 海丰 , 关 伟伟
Published: November 2020

随着中国经济的快速发展，国家越来越重视信息化环境下中职院校的信息教学工作。为了进一步提高计算机的应用范围，必须使中职院校信息化教学社会市场接轨，增强职业教育与经济发展的匹配度和适应性，实现因材施教的培养目标。因此，论文主要针对信息化环境下中职院校信息化教学综合探索进行简要分析，并提出合理化的建议。
课程思政教育理念下艺术类课程网络教学的思考——以疫情下电影课网络教学为例
Authors: 毛 美娜
Published: November 2020

自中国高校思想政治工作会议召开以来，学校党委紧紧围绕“培养什么样的人、如何培养人以及为谁培养人”这个根本问题，把课程思政作为落实立德树人根本任务的根本举措。2020年，新冠病毒疫情仍然在蔓延，学校积极落实中国北京市“停课不停学”工作部署，在教育教学上开启网络教学。疫情改变了我们的工作、生活、和学习方式，本着“停课不停学”的原则，各高校在疫情期间进行网络教学。针对实践性较强的艺术类课程，在面对网络教学该如何有效、有序、保质、保量地开展教学工作呢？论文结合所授电影课程的教育教学活动，对疫情下网络教学展开思考。
AGRICLUSTER AS THE MECHANISM OF A SUSTAINABLE DEVELOPMENT OF RURAL TERRITORIES OF THE ANDIJAN AREA OF REPUBLIC UZBEKISTAN
Authors:   Andijan Branch of Tashkent state agrarian university of the Republic of Uzbekistan, Yakubov Takhirjan
Published: November 2020

In article the actual problems connected with influence regional on improvement of social and economic indexes in villages of the Andijan area of Republic Uzbekistan are investigated. Theoretical approaches of formation are studied.The description, structure and features agricluster are given the Andijan area. In the conclusion recommendations about its development, directed on achievement of a sustainable development of rural territories are offered
IMPORTANT ISSUES IMPROVEMENT OF LIVING STANDARDS OF POPULATION AND SECURING POPULATION WITH FOOD
Authors:   INSTITUTE FOR TRAINING AND TRAINING OF MOTOR VEHICLES OF THE REPUBLIC OF UZBEKISTAN, Shodiyeva G.M. , Kalanova Mohigul ,   Samarkand economy and service institute of the Republic of Uzbekistan
Published: November 2020

The food industry is one of the important tasks of creating an effective system in this article. At the same time, it is stated that improving nutrition, optimizing nutritional standards is one of the main tasks of today
Justification of the design parameters of the grass forage dispenser
Authors: Eliseev Mikhail Semenovih , Rybalkin Dmitriy Alekseevich , Sitkaliev Azamat Sattarovich
Published: November 2020

The article proposes a design of a grass forage dispenser, which provides the necessary accuracy of product dispensing, which meets the zootechnical and technical and economic requirements for it. Calculations and results of experimental studies are presented.
Justification for the development of resource-saving technology and the production of the combined unit for strip tillage
Authors: Lukonin Nikita Andreevich , Vorotnikov Igor  Leonidovich , Bogatyrev Sergey Arkadyevich
Published: November 2020

The article presents material on an objective   feasibility of using the technology and production of  a unit for strip tillage at the preliminary stage of development and implementation of the Strip-Till system in the presence of a limited set of available parameters.
Effect of the combined use of phytohormone-producing bacteria and Chistalan herbicide on the physiological and morphological parameters of wheat plants
Authors: Feoktistova Arina Vladimirovna , Timergalin Maxim Danilovich , Rameev Timur Vilevich , Chetverikov Sergei Pavlovich
Published: November 2020

Results of the treatment with bacteria producing phytohormones, and herbicide-tolerant on physiological and morphological parameters of wheat plants with simultaneous exposure to Chistalan herbicide are presented. Strains of Pseudomonas sp. DA1.2 and P. koraiensis IB-4 prevented the suppression of plant growth, caused the redistribution of auxins between in favor of escape and a decrease in the content of ABA in the roots of wheat plants against the action of the herbicide Chistalan. The bacteria had a positive effect on the photosynthetic apparatus and reduced the development of oxidative stress caused by the herbicide. It is shown that herbicide stress is reduced under the influence of bacteria.
Pathoanatomic picture of the “section” of the mink hair
Authors: Mantatova Natalia Viktorovna , Kladova Daria Valerievna , Sanzhieva Svetlana Yegorovna
Published: November 2020

The article presents a pathoanatomic picture of Minks in the “section” of the hairline. One of these pathologies is the "section" of the hairline. In animal farms, animals with shorn hair are often found. The few studies we have found that clinically "section" hairline outwardly was a rough cut fur with small scissors; defeat the guard and guide of hair led to exposure down in the future – to the disappearance of the guard hairs. Outwardly, the hair became dull, lost its luster, and in places-stained with litter. During the pathoanatomic study of mink carcasses, it was found that in 55% of cases, no pathoanatomic changes in internal organs were observed during the "section" of the hairline. In 10% of cases, against the background of the “section”, mink had enterocolitis. The most incident was liver pathology, in 35% of cases mink had fatty hepatosis.
EFFECTS OF EXPLOSIVE STRENGTH AND STRENGTH ENDURANCE BASED CIRCUIT TRAINING ON SPEED PERFORMANCE
Authors: Maniazhagu D. , Kannadasan  , Malar S.
Published: November 2020

The purpose of the study was to find out the effects of explosive strength and strength endurance based circuit training on speed performance. To achieve the purpose of the study, thirty boys’ student in the age group 13 to 14 were selected as subjects at random. The selected subjects were from RCM High School, Natarajapuram, Sivagangai(DT), Tamilnadu. The study was formulated as pre and post-test random group design, in which thirty students were divided into three equal groups. The experimental group-1 (n=10, ESbCT) underwent explosive strength based circuit training, the experimental group-2 (n=10, SEbCT) underwent strength endurance based circuit training and group 3 served as control group (n=10, CG) did not undergo any specific training. In this study, two training programme were adopted as independent variables, i.e., explosive strength based circuit training and strength endurance based circuit training. The speed was selected as dependent variables. The speed was tested by 50 meters run recoded in seconds. The selected two treatment group namely explosive strength based circuit training and strength endurance based circuit training were performed five days in week for the period of six weeks, as per the stipulated training programme. The speed performance was collected before and after the training period. The collected pre and post test data was critically analyzed with apt statistical tool of one way analysis of co variance, for observed the significant adjusted post-test mean difference of three groups. The Scheffe’s post hoc test was used to find out pair-wise comparisons between groups. To test the hypothesis 0.05 level of significant was fixed in this study. The nature of speed highly improved in explosive strength based circuit training than the strength endurance based circuit training.
Ultrasonik Sprey Piroliz Yöntemi ile Üretilen Güneş Soğurucu CH3NH3PbI3-xClx Perovskit Yapısının Optik, Morfolojik ve Yapısal Özelliklerinin İncelenmesi
Authors: AKYÜREKLİ Salih , KALELİ Murat , KOÇ Murat , ALDEMİR Durmuş Ali
Published: November 2020

Bu çalışmada ultrasonik sprey piroliz yöntemi ile cam alttaşlar üzerine CH3NH3PbI3-xClx perovskit ince filmler kaplanmıştır. Alttaş sıcaklığının perovskit filmlerin yapısal, morfolojik ve optik özellikleri üzerine etkisi, X-ışını kırınım (XRD) cihazı, taramalı elektron mikroskobu (SEM), atomik kuvvet mikroskobu (AFM) ve Uv-Vis spektrofotometresi kullanılarak araştırılmıştır. XRD spektrumları incelendiğinde, tüm filmlerin tetragonal perovskit örgü yapısında olduğu ancak 75 °C ve 100 °C alttaş sıcaklığı uygulanan ince filmlerde farklı kristal yapılara ait fazladan piklerinde olduğu görülmüştür. Filmlere sonradan herhangi bir tavlama işlemi uygulanmadığı halde, 125 °C alttaş sıcaklığında kaplanan filmlerin literatür ile birebir uyumlu saf perovskit kristali formunda olduğu tespit edilmiştir. XRD spektrum verileri ve Debye-Scherrer formülü kullanılarak ince filmlerin kristal boyutları belirlenmiştir. En yüksek kristal boyutu 743 Å ile 125 °C alttaş sıcaklığında kaplanan filmlerde elde edilmiştir. SEM görüntüleri incelendiğinde film yüzeylerinin sadece 125 °C alttaş sıcaklığında homojen kaplandığı ve kristal tanecikler arasında boşlukların oluşmadığı saptanmıştır. Filmlerin yüzey pürüzlülüğü atomik kuvvet mikroskobu ile incelenmiş, en düşük yüzey pürüzlülüğü 41.32 nm ile 125 °C alttaş sıcaklığına sahip olan ince filmde elde edilmiştir. Optik soğurma ölçümleri, oda sıcaklığında çalıştırılan Uv-Vis spektrofotometre kullanılarak gerçekleştirilmiştir. Filmler kaplanırken uygulanan alttaş sıcaklığı artıkça filme ait yasak bant aralığının 1.20’ eV tan teorik analizler ile de uyuşan 1.56 eV’ a çıktığı görülmüştür.
131Cs Radyoizotopunun Üretildiği Bazı Nükleer Reaksiyonların Uyarılma Fonksiyonları
Authors: ZENGİN Sedat , ÖZKAN BİLİCİ Vildan , SARPÜN İsmail Hakkı
Published: November 2020

Nükleer fizikteki sürekli devam eden gelişmeler nükleer teknolojiye önemli katkılar sağlamakta ve bağlantılı olan birçok alanda da önemli gelişmeler olmasını sağlamaktadır. Bunun başlıca sebepleri çekirdeğin yapısı ve özelliklerinin anlaşılması ile nükleer reaksiyonların fiziksel teorilerinin geliştirilmesidir. Özellikle sağlık ve teknoloji alanında kullanılan nükleer reaksiyonların tesir kesitlerinin bilinmesi, reaksiyonun olası sonuçlarının kullanılması hakkında fikir vermektedir. Bazı durumlarda nükleer reaksiyonların tesir kesitlerini deneysel olarak bulmak hem maliyet hem koşullar bakımından mümkün olmaz. Reaksiyon tesir kesitleri, teorik olarak çeşitli nükleer reaksiyon kodlarıyla hesaplanmaktadır. Kanser tedavisinde kullanılan diğer radyoizotoplara göre 131Cs, daha kısa yarı ömre ve daha yüksek enerjiye sahip olmasından dolayı son yıllarda kanser tedavilerinde kullanılmaya başlanılmıştır. Bu çalışmada 131Cs radyoizotopunun elde edilmesinde kullanılan, deneysel verileri EXFOR kütüphanesinde mevcut olan 133Cs(γ,2n), 133Cs(p,x), 127I(α,γ) ve 131Xe(p,n) reaksiyonlarının uyarılma fonksiyonları incelenmiştir. TALYS 1.95 nükleer kod programı ile elde edilen teorik sonuçlar ile EXFOR veri kütüphanesinden alınan veriler karşılaştırılmıştır.
Peningkatan Penguasaan Kosakata Noun melalui Model See, Talk, Write dan Media Gambar Pada Peserta Didik Kelas 7D SMPN 2 Pasuruan
Authors: Rochmah Nur
Published: November 2020

Menurut kurikulum 13 pada mata pelajaran Bahasa Inggris, menulis dan membaca merupakan keterampilan yang harus dikuasai oleh peserta didik selain mendengarkan dan berbicara. Bagi peserta didik di tingkat SMP kelas VII mengenal Kosakata adalah  sangat penting karena dengan mengenal banyak kosakata maka belajar Bahasa Inggris menjadi sangat mudah dan menyenangkan. Untuk mempermudah menguasai kosakata Bahasa Inggris terutaman bentuk noun, penulis menggunakan model pembelajaran STW (See, Talk, and Write). Penelitian model pembelajaran STW ini diterapkan pada peserta didik kelas 7D SMPN 2 Pasuruan dan dilaksanakan dalam dua siklus. Masing-masing siklus terdiri dari Perencanaan, Pelaksanaan, Pengamatan dan Refleksi. Hasil penilaian menggunakan model pembelajaran STW menunjukkan bahwa pada siklus pertama, banyak siswa yang memiliki nilai di atas KKM adalah 17 dari 34 peserta didik (50%). Sedangkan pada siklus kedua, siswa yang memiliki nilai di atas KKM sebanyak 28 dari 34 Peserta didik (82%). Hal ini menunjukkan peningkatan secara signifikan sebesar 32%. Dengan demikian dapat disimpulkan bahwa Model Pembelajaran STW (See, Talk, and Write) dapat meningkatkan penguasaan kosakata bentuk noun pada peserta didik kelas 7D SMPN2 Pasuruan.
MEDICAL REFORM UNDER DECENTRALIZATION: CONTEMPORARY PROBLEMS AND PROSPECTS FOR RESOLUTION
Authors: Oharenko Viktor , Kozachenko Iuliana
Published: November 2020

The purpose of the paper is to identify the main prerequisites and ways of the medical reform in Ukraine under decentralization, and the emergency of fee-for-service medicine in particular. Methodology. The survey is based on the study of legally enforceable enactments which regulate medical sphere and the process of decentralization of power. Results. The article outlines the main prerequisites and ways to solve the issue of the implementation of medical reform in Ukraine under decentralization, including the emergence of fee-for-service-medicine. The problem related to health care reform in general in order to improve the availability and quality of health care have been identified. Statistical data on the main healthcare indicators in Ukraine have been presented. National healthcare accounts of Ukraine have been presented and healthcare expenditures per capita in other countries of the world has been demonstrated. Practical implications. The main steps that are necessary to undertake for implementing changes in the medical field have been determined in the article. They are the following: involvement of communities, development of social infrastructure, transportation of patients and women in labor to hospitals, involvement of social workers, support of medical institutions, and assistance by the communities in public control. It is determined that the biggest challenge for the medical sector is the reorientation to a new level of medical services. The main directions in medicine under decentralization on the implementation of material, organizational and financial conditions to provide local authorities with own and delegated powers have been emphasized. Value/originality. An approach to implementing medical reform that meets the needs of the community is developed and its essence has been explained. The complex of actions on introduction of medical reform under decentralization of the power, which has been explained as an increase in powers and financial possibilities of territorial communities has been generalized.
THE APEC INTEGRATED COMPETITIVE FORCE INDEX
Authors: Palinchak Mykola , Zayats Olena , Bokoch Viktoria
Published: November 2020

The number of actors that affect the distribution of the competitive force in the global economy is growing, and the spheres of economic competition or cooperation are expanding to build up the competitive force. The article emphasizes the significant impact of international economic integration on the sustainable economic development of the world economy. It also shows that the study of the competitive force of interstate integration groupings is highly relevant today, as international economic integration plays a fundamental role in the development of trade and competitive relations between countries. The paper offers the methodology for competitiveness grouping of Member States of the international integration groupings in order to assess the global competitive force of trade and economic groupings in the world economy. The purpose is to investigate the Integrated Competitive Force Index of Asia-Pacific Economic Cooperation (APEC) 2019 in order to analyze the attractiveness of APEC in terms of the global competitive force. It is also important to determine the attractiveness of APEC competitive environment according to 12 criteria on the basis of the research, which, in turn, allows for a better understanding and ranking of interstate integration groupings according to their competitive forces. Result. Based on the data of the Global Competitiveness Report 2019 on the competitiveness of Asia-Pacific Economic Cooperation Member States (APEC), the Integrated Competitive Force Index of APEC as an interstate integration grouping has been calculated. The Index will help to assess economic integration or disintegration processes in the global economy. The article proves the necessity of the annual integrated competitive force ranking of international integration groupings. Practical implications. The introduction of the new Integrated Competitive Force Index of interstate integration groupings will help competition policymakers to decide which processes of economic integration or disintegration should be preferred in order to build up their competitive force in the global economy.
WORLD EXPERIENCE OF PROCESS QUALITY MANAGEMENT OF TEACHER TRAINING IN HEI
Authors: Kravchenko Tetyana , Saienko Iryna
Published: November 2020

The quality of higher education is the main feature of HEI. There are several approaches to assessing the performance of educational institutions. One of the leading process approaches is based on the principles of TQM (Total Quality Management) and the requirements for quality management systems of the International Organization for Standardization ISO. The basis for assessing the quality of higher education and training, as well as the quality of HEI’s activities are educational standards. The Ukrainian standards include: state standard, industry standards, HEI’s standards. The international standards of ENQA education quality guarantees include: standards for internal quality assurance of HEI, standards for external quality assurance of HEI, the European standards for external agencies of quality assurance. There are several models of education quality management systems: model of quality management system according to the international standard ISO 9001:2000 (DSTU ISO 9001:2001); the model of the European Foundation for Quality Management (EFQM) and its modifications for HE; the model of the Center for Higher Education Policy Studies (CHEPS) of the University of Twente (Netherlands); model of the Association of Universities in the Netherlands (VSNU); Belgian-Dutch model (Expertgroep HBO); Malcolm Baldrige National Quality Award in the field of education; benchmarking model for Australian universities and others. According to most researchers, there are some advantages in creating a quality management system of higher education institution in the context of the TQM ideology, which involves the application of process and systemic principles. The comparative characterization of factors influencing the quality of education in comparison with the principles of TQM, EFQM’s criteria and the requirements of the international standard ISO 9001:2000 and interdependent business processes. In the universities of the USA, France, Great Britain and other developed countries, the problems of general process quality management are considered in three planes. The study of the positive experience of developed countries, HEIs of which are included in the world rankings, and graduates are in demand in the labor market, allows to form a mechanism for implementing the TQM principles both at the state and regional levels.
Performance Analysis of Wind Power Generation Models Using Oscillating Water Column
Authors: Susastro Susastro , Noerpamoengkas Ardi , Ulum Miftahul , Setyono Gatot
Published: November 2020

In this global era there are many resources that can be used one of them is, renewable resources such as sea waves. waves can be used as a generated of electrical energy. electrical energy that utilizes the occurrence of sea waves now can be applied in developed and developing countries. One method of conversion that can be done to convert wave energy into electrical energy is by using an oscillating water column. In this research, the turbine of oscillating water column was made using turbine wells with variations in rotation at 40, 50 and 58.3 rpm. the results it’s power of turbine, power of generator and efficiency system. The method used is the experimental method by testing the prototype using a low water wave on a laboratory scale. The results obtained from the experiment are that the electric power at the maximum load generated by the generator is 0.002875 Watt at a rotation of 50 rpm. While the lowest electric power at maximum load is 0.0004 W with a rotation of 40 rpm. The maximum efficiency of the system at load is 4.691% which occurs at a rotation of 50 rpm
Natureza e características das comissões econômicas das Nações Unidas: a especificidade da CEPAL
Authors: Almeida Filho Niemeyer
Published: November 2020

O artigo discute as circunstâncias de criação das cinco comissões econômicas da ONU, procurando apreender tanto o contexto histórico quanto as características de cada uma delas. A hipótese é que as condições históricas de criação da CEPAL abriram a possibilidade de especificidades muito relevantes ao debate sobre desenvolvimento econômico nos anos 1950 na América Latina, e na Europa e América do Norte. A CEPAL tem contribuições inscritas como heterodoxas no âmbito das teorias de desenvolvimento, engendrando uma característica de Escola de Pensamento que está ausente nas demais comissões.