bluuebunny/crossref_metadata_2025 huggingface dataset:
Association between Diabetic Peripheral Neuropathy as Measured Using a Point-of-Care Sural Nerve Conduction Device and Urinary Albumin Excretion in Patients with Type 2 Diabetes
Authors: Fukuda Tatsuya , Fujii Akiko , Akihisa Taro , Otsubo Naoya , Murakami Masanori , Yamada Tetsuya , Maki Chisato
Published: June 2023

Background: It is not well known whether diabetic peripheral neuropathy diagnosed using a non-invasive point-of-care nerve conduction device called DPN-Check® is associated with diabetic nephropathy. Thus, we aimed to evaluate the association of diabetic peripheral neuropathy with urinary albumin excretion in patients with type 2 diabetes using DPN-Check®. Methods: This retrospective observational study included 323 Japanese patients with type 2 diabetes. The urinary albumin-to-creatinine ratio in a spot urine sample was defined as urinary albumin excretion. Multiple linear regression analysis was used to determine the association of DPN-Check®-determined diabetic peripheral neuropathy with urinary albumin excretion. Results: Patients with DPN-Check®-determined diabetic peripheral neuropathy had significantly higher urinary albumin excretion than those without, while there was no difference in urinary albumin excretion between patients with and without diabetic peripheral neuropathy determined by simplified diagnostic criteria. In the multivariate model, the DPN-Check® determined that diabetic peripheral neuropathy was significantly associated with urinary albumin excretion even after adjustment for covariates (standardized β, 0.123; p = 0.012). Conclusions: Our study found a significant association between diabetic peripheral neuropathy diagnosed using DPN-Check® and urinary albumin excretion in patients with type 2 diabetes.
Direct Vertebral Rotation (DVR) Does Not Improve Clinical and Radiological Results Compared to Differential Rod Contouring (DRC) in Patients Treated Surgically for Idiopathic Scoliosis
Authors: Urbanski Wiktor , Markowski Piotr , Zaluski Rafal , Kokaveshi Anis , Morasiewicz Piotr
Published: June 2023

Direct vertebral rotation (DVR) is the most widespread method to correct axial vertebral rotation. Differential rod contouring (DRC) also includes derotation, but not to the same extent as DVR. DVR requires additional surgical effort with potential consequences, which are absent in DRC; moreover, the data concerning the clinical benefits of apical derotation are not convincing. In the present study, clinical and radiological outcomes were compared in patients who underwent surgery for adolescent idiopathic scoliosis (AIS), having DVR and DRC vs. DRC only. In total, 73 AIS patients with curves of 40–85°, consecutively operated on by one surgeon, participated in this study and were followed up over 2 years. Scores from the SRS-22 questionnaire were analysed, the angles of trunk rotation (ATR) were measured with an inclinometer and a radiographic assessment of coronal and sagittal spinal profiles was conducted. In 38 cases, only DRC was performed, and in 35 DRC was performed and followed by DVR; the groups did not differ from an epidemiological point of view. Total SRS-22 scores after 2 years were similar in both groups (4.23 (±0.33) in DRC vs. 4.06 (±0.33) in DRC/DVR, p = 0.1). In all components of SRS-22, the differences were minor, with p being way above 0.05. The mean ATR in the DRC/DVR group was slightly smaller (8 ± 4°) than that of the DRC group (10 ± 5°), p = 0.16. Radiographic analysis did not show significant differences. The coronal curve was corrected by 66 ± 12% for DRC and 63 ± 15% for DVR, p = 0.28. Thoracic kyphosis in the DRC/DVR group increased by 1°, whereas in the DRC group the average kyphosis increased by 5° with a p value of 0.07. The complication rates were similar in both groups. This investigation did not show any advantages of the combination of DRC and DVR in scoliosis correction over DRC only, both radiologically and clinically, yet it affected intraoperative parameters, extending the operation time with only a minor increase in blood loss.
Prevalence of Migraine Disease in Electrohypersensitive Patients
Authors: Greco Frédéric , Garnier Océane , Macioce Valérie , Picot Marie Christine
Published: June 2023

Background: The vast majority of electrohypersensitive (EHS) patients present headaches on contact with an electromagnetic source. Clinical features suggest that the headaches of these patients could be a variant of the migraine disease and could be treated as such. We aimed to assess the prevalence of migraine disease in EHS patients using a validated questionnaire. Methods: Patients with EHS defined according to WHO criteria were contacted through EHS patient support associations. They were required to answer a self-questionnaire including clinical data and the extended French version of the ID Migraine questionnaire (ef-ID Migraine) to screen for the migraine disease. Migraine prevalence and its 95% confidence interval (CI) were reported. Patients’ characteristics, symptoms (rheumatology, digestive, cognitive, respiratory, cardiac, mood, cutaneous, headache, perception, genital, tinnitus and tiredness) and impact on daily life were compared between migraineur and non-migraineur patients. Results: A total of 293 patients were included (97% women, mean age 57 ± 12 years). Migraine was diagnosed in 65% (N = 191; 95% CI: 60–71%) with the ef-ID Migraine. The migraine diagnosis was accompanied by nausea/vomiting in 50% of cases, photophobia in 69% or visual disturbances in 38%. All of the 12 symptoms assessed were of higher intensity in migraineurs than in non-migraineurs. The symptoms prevented social life in 88% of migraineurs and 75% of non-migraineurs (p < 0.01). Conclusions: Our work encourages us to consider the headaches of these patients as a possible variant of the migraine disease and, possibly, to manage them according to the current recommendations.
The Impact of Preclinical High Potent P2Y12 Inhibitors on Decision Making at Discharge and Clinical Outcomes in Patients with Acute Coronary Syndrome
Authors: Hammer Andreas , Krammel Mario , Aigner Patrick , Pfenneberger Georg , Schnaubelt Sebastian , Hofer Felix , Kazem Niema , Koller Lorenz , Steinacher Eva , Baumer Ulrike , Hengstenberg Christian , Niessner Alexander , Sulzgruber Patrick
Published: June 2023

Background: Purinergic signaling receptor Y12 (P2Y12) inhibitors are a fundamental part of pharmacological therapy in acute coronary syndrome (ACS) for preventing recurrent ischemic events. Current guidelines support the use of prasugrel over ticagrelor—however, ticagrelor is widely used for preclinical loading during ACS due to its ease of administration. In this regard, it remains unknown whether the preclinical loading with P2Y12 inhibitors impacts decision-making for the long-term dual antiplatelet strategy, as well as cardiovascular outcomes, including re-percutaneous coronary intervention in real-world settings. Methods: Within this population-based prospective observational study, all patients with ACS who received medical care via the Emergency Medical Service (EMS) in the city of Vienna between January 2018 and October 2020 were enrolled. Patients were stratified according to their P2Y12 inhibitor loading regimen. Subsequently, the association of P2Y12 inhibitor loading on long-term prescription at discharge and outcome was assessed. Results: The entire study cohort consisted of 1176 individuals with ST-elevation myocardial infarction (STEMI), of whom 47.5% received prasugrel and 52.5% ticagrelor. The likelihood of adhering to the initial P2Y12 inhibitor strategy during the clinical stay was high for both ticagrelor (84%; OR: 10.00; p < 0.001) and prasugrel (77%; OR: 21.26; p < 0.001). During patient follow-up (median follow-up time three years), 84 (7.1%) patients died due to cardiovascular causes, and 82 (7.0%) patients required re-PCI. Notably, there was no difference in cardiovascular mortality (6.6% ticagrelor vs. 7.7% prasugrel) or re-PCI rates (6.6% ticagrelor vs. 7.3% prasugrel) addressing the P2Y12 inhibition strategy. Conclusion: We observed that, regardless of the initial antiplatelet inhibitor strategy, the in-hospital P2Y12 adherence was exceedingly high, and there was a minimal occurrence of switching to another P2Y12 inhibitor. Most importantly, no significant difference in cardiovascular death/re-PCI between ticagrelor and prasugrel-based preclinical loading has been observed. Consequently, the choice of high potent P2Y12 did not influence the cardiac outcome from a long-term perspective.
The Lost and Found: Unraveling the Functions of Orphan Genes
Authors: Fakhar Ali Zeeshan , Liu Jinbao , Pajerowska-Mukhtar Karolina M. , Mukhtar M. Shahid
Published: June 2023

Orphan Genes (OGs) are a mysterious class of genes that have recently gained significant attention. Despite lacking a clear evolutionary history, they are found in nearly all living organisms, from bacteria to humans, and they play important roles in diverse biological processes. The discovery of OGs was first made through comparative genomics followed by the identification of unique genes across different species. OGs tend to be more prevalent in species with larger genomes, such as plants and animals, and their evolutionary origins remain unclear but potentially arise from gene duplication, horizontal gene transfer (HGT), or de novo origination. Although their precise function is not well understood, OGs have been implicated in crucial biological processes such as development, metabolism, and stress responses. To better understand their significance, researchers are using a variety of approaches, including transcriptomics, functional genomics, and molecular biology. This review offers a comprehensive overview of the current knowledge of OGs in all domains of life, highlighting the possible role of dark transcriptomics in their evolution. More research is needed to fully comprehend the role of OGs in biology and their impact on various biological processes.
Regionalized Protein Localization Domains in the Zebrafish Hair Cell Kinocilium
Authors: Erickson Timothy , Biggers William Paul , Williams Kevin , Butland Shyanne E. , Venuto Alexandra
Published: June 2023

Sensory hair cells are the receptors for auditory, vestibular, and lateral line sensory organs in vertebrates. These cells are distinguished by “hair”-like projections from their apical surface collectively known as the hair bundle. Along with the staircase arrangement of the actin-filled stereocilia, the hair bundle features a single, non-motile, true cilium called the kinocilium. The kinocilium plays an important role in bundle development and the mechanics of sensory detection. To understand more about kinocilial development and structure, we performed a transcriptomic analysis of zebrafish hair cells to identify cilia-associated genes that have yet to be characterized in hair cells. In this study, we focused on three such genes—ankef1a, odf3l2a, and saxo2—because human or mouse orthologs are either associated with sensorineural hearing loss or are located near uncharacterized deafness loci. We made transgenic fish that express fluorescently tagged versions of their proteins, demonstrating their localization to the kinocilia of zebrafish hair cells. Furthermore, we found that Ankef1a, Odf3l2a, and Saxo2 exhibit distinct localization patterns along the length of the kinocilium and within the cell body. Lastly, we have reported a novel overexpression phenotype of Saxo2. Overall, these results suggest that the hair cell kinocilium in zebrafish is regionalized along its proximal-distal axis and set the groundwork to understand more about the roles of these kinocilial proteins in hair cells.
Influence of Guide Vane Opening on the Runaway Stability of a Pump-Turbine Used for Hydropower and Ocean Power
Authors: Zhu Di , Yan Wei , Guang Weilong , Wang Zhengwei , Tao Ran
Published: June 2023

Runaway is a common phenomenon in pump-turbines for hydropower and ocean power, accompanied by strong instability, which can easily lead to accidents. This study reveals the stability during the runaway process of a pump-turbine, mainly exploring the phenomenon of guide vane rejection happening in transition conditions when dealing with hydropower or ocean power. Through model experiments and computational fluid dynamics numerical simulations, the pressure pulsation when reaching runaway was compared under different guide vane opening angles. The amplitude of pressure pulsation measured in the experiment increases with the increase in guide vane opening, but there are also local changes in size and peak. The simulation results show that when the guide vane opening angle is 12 degrees, the vortex flow in the area between the guide vane and the runner of the unit increases, leading to instability. When the opening angle of the guide vane is between 12 and 20 degrees, the vortex flow intensity does not change much and the distribution becomes uniform, resulting in a decrease in the amplitude of pressure fluctuations. The pulsation of the flow field causes a dissipation of flow energy. Relationships can be found among velocity field, vortex intensity, and entropy production. This study is of great significance for ensuring the stable operation of pump-turbines.
PIV Snapshot Clustering Reveals the Dual Deterministic and Chaotic Nature of Propeller Wakes at Macro- and Micro-Scales
Authors: D’Agostino Danny , Diez Matteo , Felli Mario , Serani Andrea
Published: June 2023

This study investigates the underlying mechanisms governing the evolution of tip vortices in the far field of a naval propeller wake. To achieve this, a novel approach utilizing data clustering applied to particle image velocimetry snapshots is employed. The clustering of data is carried out using the k-means algorithm, with the optimal number of clusters determined by evaluating two metrics: the within-cluster sum of squares and the average silhouette. The clustering of phase-locked propeller wake data is focused on the vorticity associated with the regions containing tip vortices. Additionally, techniques such as proper orthogonal decomposition, t-distributed stochastic neighbor embedding, and kernel density estimation are employed to visually represent the data clusters in a two-dimensional space, facilitating their assessment and subsequent discussion. This paper shows how the application of data clustering enables a comprehensive understanding of the complex mechanisms driving the dynamics of propeller wake vortices in both the transitional and far fields. Specifically, it reveals the dual nature of the propeller wake flow, characterized by deterministic and chaotic behavior at macro- and micro-scales.
TCRN: A Two-Step Underwater Image Enhancement Network Based on Triple-Color Space Feature Reconstruction
Authors: Lin Sen , Zhang Ruihang , Ning Zemeng , Luo Jie
Published: June 2023

The underwater images acquired by marine detectors inevitably suffer from quality degradation due to color distortion and the haze effect. Traditional methods are ineffective in removing haze, resulting in the residual haze being intensified during color correction and contrast enhancement operations. Recently, deep-learning-based approaches have achieved greatly improved performance. However, most existing networks focus on the characteristics of the RGB color space, while ignoring factors such as saturation and hue, which are more important to the human visual system. Considering the above research, we propose a two-step triple-color space feature fusion and reconstruction network (TCRN) for underwater image enhancement. Briefly, in the first step, we extract LAB, HSV, and RGB feature maps of the image via a parallel U-net-like network and introduce a dense pixel attention module (DPM) to filter the haze noise of the feature maps. In the second step, we first propose the utilization of fully connected layers to enhance the long-term dependence between high-dimensional features of different color spaces; then, a group structure is used to reconstruct specific spacial features. When applied to the UFO dataset, our method improved PSNR by 0.21% and SSIM by 0.1%, compared with the second-best method. Numerous experiments have shown that our TCRN brings competitive results compared with state-of-the-art methods in both qualitative and quantitative analyses.
Global Changes Alter the Successions of Early Colonizers of Benthic Surfaces
Authors: Somma Emanuele , Terlizzi Antonio , Costantini Maria , Madeira Madalena , Zupo Valerio
Published: June 2023

The successions of benthic communities over time are strongly influenced by the first colonizers, because surface associations are facilitated by modifications to the adhesive properties promoted by primary colonizers, such as bacteria, protozoans, diatoms, algal propagules, spores, and invertebrate larvae. Bacteria are often the first colonizers on marine submerged surfaces, both organic (e.g., algae, seagrasses and invertebrates) and inorganic. However, they are promptly followed by diatoms and other microorganisms. Consequently, diatoms may represent key elements in the determination of the colonization patterns, although the development of epiphytic communities is a dynamic process influenced by several factors, including nutrient availability, the ability to synthesize and secrete extracellular material, the competition among species and the influence of grazers on individual colonizers. The process may be drastically impacted by global warming and ocean acidification due to the increasing atmospheric levels of CO2. The impact of such global stressors on benthic ecosystems, especially on the primary microphytobenthic assemblages, is still poorly investigated, and may have deleterious consequences for the benthic successions. In this review, we analyze the adhesion patterns of marine microorganisms according to their surface features and the effects of global changes on critical pioneer colonizers, such as the benthic diatoms. The results are remarkable, as they highlight emergent concerns in ecosystem conservation and the prediction of benthic communities.
Etiology, Predisposing Factors, Clinical Features and Diagnostic Procedure of Otomycosis: A Literature Review
Authors: Bojanović Mila , Stalević Marko , Arsić-Arsenijević Valentina , Ignjatović Aleksandra , Ranđelović Marina , Golubović Milan , Živković-Marinkov Emilija , Koraćević Goran , Stamenković Bojana , Otašević Suzana
Published: June 2023

Otomycosis (OM) is a superficial fungal infection of the external auditory canal (EAC) with a worldwide prevalence ranging from 9% to 30%. Commonly, otomycoses are caused by Aspergillus (A.) niger complex and Candida spp. Other causative agents are yeasts of the genera Cryptococcus spp., Rhodotorula spp., Geotrichum candidum, dermatophytes (Trichophyton mentagrophytes), and non-dermatophytes molds (Fusarium spp., Penicillium spp., Mucorales fungi). The widest range of different species causing OM are found in the territories of Iran, India, China, Egypt, Mexico, and Brazil. Fungal infection of the EAC varies from mild to severe forms. It can be acute, subacute, or chronic, and is often unilateral, while the bilateral form is more common in immunocompromised patients. From an epidemiological point of view, tropical and subtropical climates are the most significant risk factor for the development of otomycosis. Other predisposing conditions include clothing habits, EAC hygiene practices, long-term antibiotic therapy, diabetes, and immunodeficiency. Since it is often difficult to distinguish otomycosis from an infection of a different origin, laboratory-based evidence, including standard procedures (microscopy and cultivation), is essential for diagnosis. For the treatment of this superficial fungal infection, there are no official therapeutic guidelines and protocols. However, many antifungals for local application, such as polyene, imidazoles, and allylamines, can be applied, as well as systemic antimycotics (triazoles) in severe forms of infection.
Clorgyline Analogs Synergize with Azoles against Drug Efflux in Candida auris
Authors: Toepfer Stephanie , Lackner Michaela , Keniya Mikhail V. , Zenz Lisa-Maria , Friemert Marianne , Bracher Franz , Monk Brian C.
Published: June 2023

Concern about the global emergence of multidrug-resistant fungal pathogens led us to explore the use of combination therapy to combat azole resistance in Candida auris. Clorgyline had previously been shown to be a multi-target inhibitor of Cdr1 and Mdr1 efflux pumps of Candida albicans and Candida glabrata. A screen for antifungal sensitizers among synthetic analogs of Clorgyline detected interactions with the C. auris efflux pump azole substrates Posaconazole and Voriconazole. Of six Clorgyline analogs, M19 and M25 were identified as potential sensitizers of azole resistance. M19 and M25 were found to act synergistically with azoles against resistant C. auris clade I isolates and recombinant Saccharomyces cerevisiae strains overexpressing C. auris efflux pumps. Nile Red assays with the recombinant strains showed M19 and M25 inhibited the activity of Cdr1 and Mdr1 efflux pumps that are known to play key roles in azole resistance in C. auris clades I, III, and IV. While Clorgyline, M19 and M25 uncoupled the Oligomycin-sensitive ATPase activity of Cdr1 from C. albicans and C. auris, their mode of action is yet to be fully elucidated. The experimental combinations described herein provides a starting point to combat azole resistance dominated by overexpression of CauCdr1 in C. auris clades I and IV and CauMdr1 in C. auris clade III.
Synergistic Reduction of Arsenic Uptake and Alleviation of Leaf Arsenic Toxicity in Maize (Zea mays L.) by Arbuscular Mycorrhizal Fungi (AMF) and Exogenous Iron through Antioxidant Activity
Authors: Zhou Hong-Yin , Nian Fu-Zhao , Chen Bao-Dong , Zhu Yong-Guan , Yue Xian-Rong , Zhang Nai-Ming , Xia Yun-Sheng
Published: June 2023

Arbuscular mycorrhizal fungi (AMF) play key roles in enhancing plant tolerance to heavy metals, and iron (Fe) compounds can reduce the bioavailability of arsenic (As) in soil, thereby alleviating As toxicity. However, there have been limited studies of the synergistic antioxidant mechanisms of AMF (Funneliformis mosseae) and Fe compounds in the alleviation of As toxicity on leaves of maize (Zea mays L.) with low and moderate As contamination. In this study, a pot experiment was conducted with different concentrations of As (0, 25, 50 mgꞏkg−1) and Fe (0, 50 mgꞏkg−1) and AMF treatments. Results showed that under low and moderate As concentrations (As25 and As50), the co-inoculation of AMF and Fe compound significantly increased the biomass of maize stems and roots, phosphorus (P) concentration, and P-to-As uptake ratio. Moreover, the co-inoculation of AMF and Fe compound addition significantly reduced the As concentration in stem and root, malondialdehyde (MDA) content in leaf, and soluble protein and non-protein thiol (NPT) contents in leaf of maize under As25 and As50 treatments. In addition, co-inoculation with AMF and Fe compound addition significantly increased the activities of catalase (CAT), peroxidase (POD), and superoxide dismutase (SOD) in the leaves of maize under As25 treatment. Correlation analysis showed that stem biomass and leaf MDA content were very significantly negatively correlated with stem As content, respectively. In conclusion, the results indicated that the co-inoculation of AMF and Fe compound addition can inhibit As uptake and promote P uptake by maize under low and moderate As contamination, thereby mitigating the lipid peroxidation on maize leaves and reducing As toxicity by enhancing the activities of antioxidant enzymes under low As contamination. These findings provide a theoretical basis for the application of AMF and Fe compounds in the restoration of cropland soil contaminated with low and moderate As.
Development of a Dynamic Network Model to Identify Temporal Patterns of Structural Malformations in Zebrafish Embryos Exposed to a Model Toxicant, Tris(4-chlorophenyl)methanol
Authors: Schwartz Ashley V. , Sant Karilyn E. , George Uduak Z.
Published: June 2023

Embryogenesis is a well-coordinated process relying on precise cues and environmental signals that direct spatiotemporal embryonic patterning. Quite often, when one error in this process occurs, others tend to co-occur. We posit that investigating the co-occurrence of these abnormalities over time would yield additional information about the mode of toxicity for chemicals. Here, we use the environmental contaminant tris(4-chlorophenyl)methanol (TCPMOH) as a model toxicant to assess the relationship between exposures and co-occurrence of developmental abnormalities in zebrafish embryos. We propose a dynamic network modeling approach to study the co-occurrence of abnormalities, including pericardial edema, yolk sac edema, cranial malformation, spinal deformity, delayed/failed swim bladder inflation, and mortality induced by TCPMOH exposure. TCPMOH-exposed samples revealed increased abnormality co-occurrence when compared to controls. The abnormalities were represented as nodes in the dynamic network model. Abnormalities with high co-occurrence over time were identified using network centrality scores. We found that the temporal patterns of abnormality co-occurrence varied between exposure groups. In particular, the high TCPMOH exposure group experienced abnormality co-occurrence earlier than the low exposure group. The network model also revealed that pericardial and yolk sac edema are the most common critical nodes among all TCPMOH exposure levels, preceding further abnormalities. Overall, this study introduces a dynamic network model as a tool for assessing developmental toxicology, integrating structural and temporal features with a concentration response.
Provenance Data Management in Health Information Systems: A Systematic Literature Review
Authors: Sembay Márcio José , de Macedo Douglas Dyllon Jeronimo , Júnior Laércio Pioli , Braga Regina Maria Maciel , Sarasa-Cabezuelo Antonio
Published: June 2023

Aims: This article aims to perform a Systematic Literature Review (SLR) to better understand the structures of different methods, techniques, models, methodologies, and technologies related to provenance data management in health information systems (HISs). The SLR developed here seeks to answer the questions that contribute to describing the results. Method: An SLR was performed on six databases using a search string. The backward and forward snowballing technique was also used. Eligible studies were all articles in English that presented on the use of different methods, techniques, models, methodologies, and technologies related to provenance data management in HISs. The quality of the included articles was assessed to obtain a better connection to the topic studied. Results: Of the 239 studies retrieved, 14 met the inclusion criteria described in this SLR. In order to complement the retrieved studies, 3 studies were included using the backward and forward snowballing technique, totaling 17 studies dedicated to the construction of this research. Most of the selected studies were published as conference papers, which is common when involving computer science in HISs. There was a more frequent use of data provenance models from the PROV family in different HISs combined with different technologies, among which blockchain and middleware stand out. Despite the advantages found, the lack of technological structure, data interoperability problems, and the technical unpreparedness of working professionals are still challenges encountered in the management of provenance data in HISs. Conclusion: It was possible to conclude the existence of different methods, techniques, models, and combined technologies, which are presented in the proposal of a taxonomy that provides researchers with a new understanding about the management of provenance data in HISs.
Diffuse Idiopathic Skeletal Hyperostosis (DISH): Role of Logopedic Rehabilitation in Dysphagia
Authors: Mesolella Massimo , Buono Sarah , D’Aniello Roberto , Ascione Annarita , Motta Gaetano , Allosso Salvatore
Published: June 2023

Forestier’s disease is a systemic, degenerative metabolic condition, which is still insufficiently investigated and understood, characterized by the progressive ossification of the ligaments and entheses. This case describes a 63-year-old man admitted to our department after several years of failed attempts to obtain a definitive diagnosis presenting with a painless mass in the pre-auricular region, gradually worsening dysphonia, severe dysphagia relating to solids, stiffness, and mild pain at the back of the neck. After performing further diagnostic tests, in addition to a pleomorphic adenoma, the simultaneous presence of diffuse spondylarthrosis on the cervical spine was highlighted, with beak-like osteophytes at C2–C5 resulting in esophageal compression. Given the absence of upper digestive endoscopy abnormalities, we initiated an intense logopedic and postural rehabilitative treatment, which led to a significant improvement in the patient’s dysphagia symptoms. In addition, we limited the use of medical therapy to solely indomethacin in order to control the osteophytic process.
The Effects of Vitamin D Supplementation before 20 Weeks of Gestation on Preeclampsia: A Systematic Review
Authors: Dahma George , Reddy Gowry , Craina Marius , Dumitru Catalin , Popescu Alin , Stelea Lavinia , Neamtu Radu , Gluhovschi Adrian , Nitu Razvan , Maghiari Anca Laura , Tapalaga Gianina , Arnautu Diana Aurora , Nelluri Aditya , Maganti Ram Kiran , Bernad Elena
Published: June 2023

Preeclampsia is a leading cause of maternal and fetal morbidity and mortality worldwide. The role of vitamin D supplementation during early pregnancy in the prevention of preeclampsia remains unclear. Our objective was to synthesize and critically appraise the available evidence from observational and interventional studies to determine the effects of early pregnancy vitamin D supplementation on the risk of preeclampsia. A systematic review was conducted in March 2023 using PubMed, Web of Science, Cochrane, and Scopus databases, including literature published up to February 2023. In adherence to PRISMA guidelines, a structured and systematic search strategy was employed. A total of five studies were included in the review, encompassing 1474 patients. Overall, vitamin D supplementation during early pregnancy was associated with a reduced incidence of preeclampsia in all studies (ORs ranging from 0.26 to 0.31), while others showed an increased risk of preeclampsia with low vitamin D levels during the first trimester (ORs of 4.60, 1.94, and 2.52). However, other studies found no significant protective effect but good overall safety for various vitamin D dosages administered during the first trimester. Nevertheless, variations in vitamin D dosage, the timing of supplementation, and definitions of vitamin D insufficiency may have contributed to the inconsistencies in the observed outcomes. Some studies reported significant secondary outcomes, such as a reduction in blood pressure, preterm labor, and improved neonatal outcomes, such as birth weight. The evidence from this systematic review suggests that early pregnancy vitamin D supplementation may have a role in reducing the risk of preeclampsia. However, inconsistencies in the timing of supplementation, dosages, and methodological differences between studies highlight the need for further research to determine the optimal supplementation strategy and to clarify the relationship between vitamin D and preeclampsia risk.
Cost-Effectiveness Analysis of Personalized Hypertension Prevention
Authors: Wang Sen-Te , Lin Ting-Yu , Chen Tony Hsiu-Hsi , Chen Sam Li-Sheng , Fann Jean Ching-Yuan
Published: June 2023

Background: While a population-wide strategy involving lifestyle changes and a high-risk strategy involving pharmacological interventions have been described, the recently proposed personalized medicine approach combining both strategies for the prevention of hypertension has increasingly gained attention. However, a cost-effectiveness analysis has been hardly addressed. This study was set out to build a Markov analytical decision model with a variety of prevention strategies in order to conduct an economic analysis for tailored preventative methods. Methods: The Markov decision model was used to perform an economic analysis of four preventative strategies: usual care, a population-based universal approach, a population-based high-risk approach, and a personalized strategy. In all decisions, the cohort in each prevention method was tracked throughout time to clarify the four-state model-based natural history of hypertension. Utilizing the Monte Carlo simulation, a probabilistic cost-effectiveness analysis was carried out. The incremental cost-effectiveness ratio was calculated to estimate the additional cost to save an additional life year. Results: The incremental cost-effectiveness ratios (ICER) for the personalized preventive strategy versus those for standard care were -USD 3317 per QALY gained, whereas they were, respectively, USD 120,781 and USD 53,223 per Quality-Adjusted Life Year (QALY) gained for the population-wide universal approach and the population-based high-risk approach. When the ceiling ratio of willingness to pay was USD 300,000, the probability of being cost-effective reached 74% for the universal approach and was almost certain for the personalized preventive strategy. The equivalent analysis for the personalized strategy against a general plan showed that the former was still cost-effective. Conclusions: To support a health economic decision model for the financial evaluation of hypertension preventative measures, a personalized four-state natural history of hypertension model was created. The personalized preventive treatment appeared more cost-effective than population-based conventional care. These findings are extremely valuable for making hypertension-based health decisions based on precise preventive medication.
Effects of Adenotonsillectomy on Vocal Function
Authors: Mesolella Massimo , Motta Giovanni , Allosso Salvatore , Motta Gaetano
Published: June 2023

Introduction: Correct breathing is a fundamental condition for adequate vocal production. Respiratory dynamics are able to modify the growth of facial mass and lingual posture, i.e., of the skull, the mandibular one. For this reason, infant mouth breathing can cause hoarseness. Materials and methods: We evaluated the actual changes in the characteristics of the voice and articulation of language in a group of subjects affected by adenotonsillar hypertrophy (grade 3–4), with frequent episodes of pharyngo-tonsillitis who underwent adenotonsillectomy. Our study included 20 children—10 boys and 10 girls—aged 4 to 11 years who had adenotonsillar hypertrophy and pharyngotonsillitis episodes exceeding 5–6 per year in the previous 2 years. The control group (Group B) included 20 children—10 boys and 10 girls—aged 4 to 11 years (average age of 6.4 years) who had not undergone surgery and shared the same degree of adenotonsillar hypertrophy as those in Group A but who did not experience recurrent pharyngotonsillitis episodes. Discussion: The hypertrophy of adenoids and tonsils significantly impacted breathing, vocal function, and speech articulation. All this is responsible for a state of tension in the neck muscles, which at the level of the vocal tract causes hoarseness. The changes objectively observed in our study in the pre- and post-operative phase demonstrate how adenotonsillar hypertrophy is responsible for an increase in resistance to the passage of air at the glottic level. Conclusions: For this reason, adenotonsillectomy has an impact on recurrent infections and can also lead to an improvement in speech, breathing, and posture.
Characteristic-Mode-Analysis-Based Compact Vase-Shaped Two-Element UWB MIMO Antenna Using a Unique DGS for Wireless Communication
Authors: Kempanna Subhash Bodaguru , Biradar Rajashekhar C. , Kumar Praveen , Kumar Pradeep , Pathan Sameena , Ali Tanweer
Published: June 2023

The modern electronic device antenna poses challenges regarding broader bandwidth and isolation due to its multiple features and seamless user experience. A compact vase-shaped two-port ultrawideband (UWB) antenna is presented in this work. A circular monopole antenna is modified by embedding the multiple curved segments onto the radiator and rectangular slotted ground plane to develop impedance matching in the broader bandwidth from 4 to 12.1 GHz. The UWB monopole antenna is recreated horizontally with a separation of less than a quarter wavelength of 0.13 λ (λ computed at 4 GHz) to create a UWB multiple input and multiple output (MIMO) antenna with a geometry of 20 × 29 × 1.6 mm3. The isolation in the UWB MIMO antenna is enhanced by inserting an inverted pendulum-shaped parasitic element on the ground plane. This modified ground plane acts as a decoupling structure and provides isolation below 21 dB across the 5–13.5 GHz operating frequency. The proposed UWB MIMO antenna’s significant modes and their contribution to antenna radiation are analyzed by characteristic mode analysis. Further, the proposed antenna is investigated for MIMO diversity features, and its values are found to be ECC < 0.002, DG ≈ 10 dB, TARC < −10 dB, CCL < 0.3 bps/Hz, and MEG < −3 dB. The proposed antenna’s time domain characteristics in different antenna orientations show a group delay of less than 1 ns and a fidelity factor larger than 0.9.
Correction: Balgah et al. Impacts of Floods on Agriculture-Dependent Livelihoods in Sub-Saharan Africa: An Assessment from Multiple Geo-Ecological Zones. Land 2022, 12, 334
Authors: Balgah Roland Azibo , Ngwa Kester Azibo , Buchenrieder Gertrud Rosa , Kimengsi Jude Ndzifon
Published: June 2023

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A Mixed Lubrication Deterministic Model of an Elastic Support Water-Lubricated Tilting Pad Thrust Bearing
Authors: Liang Xingxin , Han Muyu , He Tao , Cui Lijun , Yang Zhiyong , Ouyang Wu
Published: June 2023

In order to study the effect of surface roughness on lubrication performance of an elastic support water-lubricated tilting pad thrust bearing, a mixed lubrication (ML) deterministic model is hereby presented based on a unified Reynolds equation model. This very model incorporates the elastic–plastic deformation of asperities and polymer matrix of the thrust pad, as well as the elastic deformation of the rubber support. The randomly distributed surface roughness of the thrust pad is generated by a mathematical model and shares the same distribution characteristics as the measured surface roughness. The Greenwood and Williamson asperity contact model and thin plate deformation model are combined to solve the asperities contact stress and deformation. Meanwhile, the bearing ML performance is compared with the results calculated by a thermohydrodynamic (THD) lubrication model and a thermo-elasto-hydrodynamic (TEHD) lubrication model, while the film thickness is also compared with measurements. The results show that the water film thickness calculated by the ML model is smaller than that by the THD model and the TEHD model, but the water film temperature is higher. The roughness has a great influence on the contact area ratio and the lubrication state, but little effect on the average film thickness. A higher roughness indicates a higher rotational speed required for the bearing to achieve full hydrodynamic lubrication. The film thickness calculated by the mixed lubrication model is closer to the measured results. Overall, it is proved that the mixed lubrication model can more accurately predict the lubrication performance of bearings. Compared to the thin plate deformation model, the elastic deformation simulation based on the half-infinite space model severely overestimates the elastic deformation of the pad surface, making it unsuitable for calculating the elastic deformation of the polymer matrix of the thrust pad under contact force or water film pressure. This ML deterministic model provides an effective means for high-precision prediction of the lubrication performance of the elastic supported water-lubricated thrust bearings coupled with multi-layer soft materials.
(trans-Dihydroxo)Sn(IV)-[5,10,15,20-tetrakis(2-pyridyl)porphyrin]
Authors: Shee Nirmal Kumar , Kim Hee-Joon
Published: June 2023

Sn(IV)-porphyrin complex with trans-dihydroxo axial-ligands and 2-pyridyl peripheral substituents, namely (trans-dihydroxo)[5,10,15,20-tetrakis(2-pyridyl)porphyrinato]tin(IV) was synthesized and fully characterized by various techniques such as elemental analysis, 1H NMR spectroscopy, ESI-MS spectrometry, UV-visible spectroscopy, and fluorescence spectroscopy.
Effects of Multiple Reflow on the Formation of Primary Crystals in Sn-3.5Ag and Solder Joint Strength: Experimental and Finite Element Analysis
Authors: Amli Siti Farahnabilah Muhd , Salleh Mohd Arif Anuar Mohd , Aziz Mohd Sharizal Abdul , Yasuda Hideyuki , Nogita Kazuhiro , Abdullah Mohd Mustafa Al Bakri , Nemes Ovidiu , Sandu Andrei Victor , Vizureanu Petrica
Published: June 2023

The growth and formation of primary intermetallics formed in Sn-3.5Ag soldered on copper organic solderability preservative (Cu-OSP) and electroless nickel immersion gold (ENIG) surface finish after multiple reflows were systematically investigated. Real-time synchrotron imaging was used to investigate the microstructure, focusing on the in situ growth behavior of primary intermetallics during the solid–liquid–solid interactions. The high-speed shear test was conducted to observe the correlation of microstructure formation to the solder joint strength. Subsequently, the experimental results were correlated with the numerical Finite Element (FE) modeling using ANSYS software to investigate the effects of primary intermetallics on the reliability of solder joints. In the Sn-3.5Ag/Cu-OSP solder joint, the well-known Cu6Sn5 interfacial intermetallic compounds (IMCs) layer was observed in each reflow, where the thickness of the IMC layer increases with an increasing number of reflows due to the Cu diffusion from the substrate. Meanwhile, for the Sn-3.5Ag/ENIG solder joints, the Ni3Sn4 interfacial IMC layer was formed first, followed by the (Cu, Ni)6Sn5 IMC layer, where the formation was detected after five cycles of reflow. The results obtained from real-time imaging prove that the Ni layer from the ENIG surface finish possessed an effective barrier to suppress and control the Cu dissolution from the substrates, as there is no sizeable primary phase observed up to four cycles of reflow. Thus, this resulted in a thinner IMC layer and smaller primary intermetallics, producing a stronger solder joint for Sn-3.5Ag/ENIG even after the repeated reflow process relative to the Sn-3.5Ag/Cu-OSP joints.
Bioactive Glass-Enhanced Resins: A New Denture Base Material
Authors: Raszewski Zbigniew , Chojnacka Katarzyna , Mikulewicz Marcin , Alhotan Abdulaziz
Published: June 2023

Background: The creation of the denture base material with bioactive properties that releases ions and produces hydroxyapatite. Methods: Acrylic resins were modified by the addition of 20% of four types of bioactive glasses by mixing with powders. Samples were subjected to flexural strength (1, 60 days), sorption and solubility (7 days), and ion release at pH 4 and pH 7 for 42 days. Hydroxyapatite layer formation was measured using infrared. Results: Biomin F glass-containing samples release fluoride ions for a period of 42 days (pH = 4; Ca = 0.62 ± 0.09; P = 30.47 ± 4.35; Si = 22.9 ± 3.44; F = 3.1 ± 0.47 [mg/L]). The Biomin C (contained in the acrylic resin releases (pH = 4; Ca = 41.23 ± 6.19; P = 26.43 ± 3.96; Si = 33.63 ± 5.04 [mg/L]) ions for the same period of time. All samples have a flexural strength greater than 65 MPa after 60 days. Conclusion: The addition of partially silanized bioactive glasses allows for obtaining a material that releases ions over a longer period of time. Clinical significance: This type of material could be used as a denture base material, helping to preserve oral health by preventing the demineralization of the residual dentition through the release of appropriate ions that serve as substrates for hydroxyapatite formation.
On Boussinesq’s Problem for a Power-Law Graded Elastic Half-Space on Elliptical and General Contact Domains
Authors: Willert Emanuel
Published: June 2023

The indentation of a power-law graded elastic half-space by a rigid counter body is considered in the framework of linear elasticity. Poisson’s ratio is assumed to be constant over the half-space. For indenters with an ellipsoidal power-law shape, an exact contact solution is derived, based on the generalizations of Galin’s theorem and Barber’s extremal principle for the inhomogeneous half-space. As a special case, the elliptical Hertzian contact is revisited. Generally, elastic grading with a positive grading exponent reduces the contact eccentricity. Fabrikant’s approximation for the pressure distribution under a flat punch of arbitrary planform is generalized for power-law graded elastic media and compared with rigorous numerical calculations based on the boundary element method (BEM). Very good agreement between the analytical asymptotic solution and the numerical simulation is obtained for the contact stiffness and the contact pressure distribution. A recently published approximate analytic solution for the indentation of a homogeneous half-space by a counter body, whose shape slightly deviates from axial symmetry but is otherwise arbitrary, is generalized for the power-law graded half-space. The approximate procedure for the elliptical Hertzian contact exhibits the same asymptotic behavior as the exact solution. The approximate analytic solution for the indentation by a pyramid with square planform is in very good agreement with a BEM-based numerical solution of the same problem.
Natural Plant-Derived Compounds in Food and Cosmetics: A Paradigm of Shikonin and Its Derivatives
Authors: Malik Sonia , Brudzyńska Patrycja , Khan Muhammad Rehan , Sytar Oksana , Makhzoum Abdullah , Sionkowska Alina
Published: June 2023

Shikonin and its derivatives are the natural naphthoquinone compounds produced in the roots of the Boraginaceae family. These red pigments have been used for a long time in coloring silk, as food colorants, and in the Chinese traditional system of medicines The resurgence of public interest in natural and plant-based products has led to this category of compounds being in high demand due to their wide range of biological activities including antioxidant, antitumor, antifungal, anti-inflammatory ones. Different researchers worldwide have reported various applications of shikonin derivatives in the area of pharmacology. Nevertheless, the use of these compounds in the food and cosmetics fields needs to be explored more in order to make them available for commercial utilization in various food industries as a packaging material and to enhance their shelf life without any side effects. Similarly, the antioxidant properties and skin whitening effects of these bioactive molecules may be used successfully in various cosmetic formulations. The present review delves into the updated knowledge on the various properties of shikonin derivatives in relation to food and cosmetics. The pharmacological effects of these bioactive compounds are also highlighted. Based on various studies, it can be concluded that these natural bioactive molecules have potential to be used in different sectors, including functional food, food additives, skin, health care, and to cure various diseases. Further research is required for the sustainable production of these compounds with minimum disturbances to the environment and in order to make them available in the market at an economic price. Simultaneous studies utilizing recent techniques in computational biology, bioinformatics, molecular docking, and artificial intelligence in laboratory and clinical trials would further help in making these potential candidates promising alternative natural bioactive therapeutics with multiple uses.