bluuebunny/crossref_metadata_2025 huggingface dataset:
Vivencias PET a importância das visitas domiciliares
Authors: Veiga Jaqueline Fátima Previatti , Stabach Franciele Aparecida Lech , Stoeberl Juliane , Mendes Milena Souza , Campos Renata , Fonseca Juliana Huttl , Cassias Susanne
Published: December 2020

Introdução: A visita domiciliar é uma técnica que vem sendo utilizada por diferentes profissionais, consistindo no atendimento ou acompanhamento dos usuários no seu local de residência, as visitas domiciliares podem servir como uma forma de criar fortes vínculos afetivos com pacientes, especialmente os que podem estar com dificuldade de locomoção ou com depressão, no Brasil, a visita domiciliar aparece como uma atividade realizada dentro do Sistema Único de Saúde (SUS) pelos profissionais das equipes de atenção primária, chamadas de Estratégia Saúde da Família (ESF)¹. Para a realização dessa atividade, são necessários planejamento, execução, registro de dados e avaliação, o registro é considerado um critério de avaliação da assistência prestada nos serviços de saúde². Objetivo: O objetivo das visitas foi acompanhar os usuários com hipertensão e diabetes, realizar uma anamnese, verificar se os mesmos estavam indo nos grupos de Hiperdia, incentivá-los a ir e também a fazer exercícios físicos, como também possuir uma alimentação saudável. Metodologia: Baseando-se no apoio às Agentes Comunitárias de Saúde de cada ESF responsável pela sua área de cobertura dos municípios de Mafra, Papanduva e Rio Negrinho, as bolsistas puderam visitar 21 famílias, sendo 57% dos participantes do sexo feminino e 43% do sexo masculino. As visitas foram realizadas aos usuários com hipertensão e diabetes, durante a visita às bolsistas do Pet Saúde realizaram uma anamnese sobre os hábitos alimentares, prática de atividade física e se participavam dos grupos de Hiperdia das ESF. Resultados: 63% dos usuários participavam do Hiperdia mensalmente, 19 usuários tinham Hipertensão Arterial Sistêmica (HAS), 16 Diabetes Mellitus e 04 apresentavam outras comorbidades como trombose, problemas cardíacos, colesterol e triglicerídeos alto. Após as visitas foi elaborado folders auto explicativos com opções de atividades físicas como alongamentos, e dicas de como manter uma boa saúde mental, além disso também aferiram a pressão arterial dos usuários, que no momento da aferição estavam alteradas. Durante as visitas às bolsistas puderam perceber o papel de cada familiar no cuidado do usuário, incentivando os mesmos a participar dos grupos de Hiperdia, a ter uma alimentação saudável e o quanto a mesma é importante no tratamento do usuário. Considerações finais: Observou-se que a atuação interprofissional fortifica as atividades para os usuários com diabetes e hipertensão, pois as visitas realizadas pelas bolsistas permitiram um acompanhamento e um atendimento integral abordando usuários com doenças crônicas não transmissíveis sobre os grupos de Hiperdia na ESF. Concomitantemente, desenvolveram habilidades interprofissionais, essenciais no dia a dia do profissional de saúde.

Palavras-chave: Visita Domiciliar. Estratégia Saúde da Família. Profissionais de Saúde.
Im Spannungsfeld zwischen Tun und Lassen – ein medizinphilosophischer Beitrag
Authors: Gerber Beat
Published: December 2020

Die Medizin ist im Wandel und ebenso unser Verständnis von Gesundheit und Krankheit. Die unaufhaltsame Technisierung unserer Lebenswelt verändert auch das Denken und Handeln in der Medizin. Immer mehr wird machbar, immer weniger scheint unmöglich. Die Medizin breitet sich aus und sie beansprucht im Leben jedes Einzelnen und in der Gesellschaft zunehmend mehr Platz. Hier gilt es, innezuhalten und sich über diese Entwicklung Gedanken zu machen. Dazu sind Klärungen zu drei wesentlichen und oft gebrauchten Begriffen der Medizin hilfreich: Es geht um das Begriffspaar Gesundheit und Krankheit, um den Begriff der Medikalisierung und um den der Macht in der Medizin. Die Geschichte der Medizin ist eine Erfolgsgeschichte – darüber besteht kein Zweifel. Stets aber regt sie zum Handeln, zum korrektiven Intervenieren an. Entsprechend ist das Tun das Übliche, das Unterlassen dagegen die Ausnahme. Dies gilt es zu beachten und zu hinterfragen – denn Unterlassen gilt in der Medizin als heikel, es ist gegebenenfalls einklagbar und entspricht so gar nicht unserem aktivistischen Denken und Handeln. Es gibt aber Situationen, in denen das Nichthandeln für den betroffenen Patienten die klar bessere Option ist. Um dieses situative Nicht(s)tun in der Medizin geht es in diesem Beitrag. Es braucht eine ausgewogene und paritätische Praxis des Handelns und des Nichthandelns, welche immer das Optimale für den Patienten im Visier hat. Keiner der beiden Optionen, weder dem Tun noch dem Nicht(s)tun, steht ein Primat zu, denn beide Handlungsweisen sind in ihrer Dignität ebenbürtig.
SPIRITUAL TEACHERS IN THAI COMMUNITY IN THAN UYEN DISTRICT, LAI CHAU PROVINCE
Authors: Tiến Đinh Đức , Minh Tô Quang
Published: December 2020

The Thai people in Than Uyen are part of the Northwest Thai people. They also share the same cultural traits, especially the spiritual culture of this land. In the spiritual life of the Thai people in Than Uyen, the spiritual teachers always hold an important position and role. On the one hand, they are "spiritual guides", responsible for taking care of the cultural and spiritual life of the whole community. On the other hand, they are also members with a lot of contributions and closely attached to society. With the study of the difficulties and contributions of Thai spiritual teachers to the community, the article contributes more voices to the preservation of Thai folk knowledge.
Experimental study ofin-situW/O emulsification during the injection of MgSO4and Na2CO3solutions in a glass micromodel
Authors: Palizdan Sepideh , Doryani Hossein , Riazi Masoud , Malayeri Mohammad Reza
Published: December 2020

In-situemulsification of injected brines of various types is gaining increased attention for the purpose of enhanced oil recovery. The present experimental study aims at evaluating the impact of injecting various solutions of Na2CO3and MgSO4 at different flow rates resembling those in the reservoir and near wellbore using a glass micromodel with different permeability regions. Emulsification process was visualized through the injection of deionized water and different brines at different flow rates. The experimental results showed that the extent of emulsions produced in the vicinity of the micromodel exit was profoundly higher than those at the entrance of the micromodel. The injection of Na2CO3brine after deionized water caused the impact of emulsification process more efficiently for attaining higher oil recovery than that for the MgSO4brine. For instance, the injection of MgSO4solution after water flooding increased oil recovery only up to 1%, while the equivalent figure for Na2CO3was 28%. It was also found that lower flow rate of injection would cause the displacement front to be broadened since the injected fluid had more time to interact with the oil phase. Finally, lower injection flow rate reduced the viscous force of the displacing fluid which led to lesser occurrence of viscous fingering phenomenon.
Novel Inhibitors of Eukaryotic Elongation Factor 2 Kinase: In Silico, Synthesis, and in Vitro Studies
Authors: CÖMERT ÖNDER Ferah , DURDAĞI Serdar , Kahraman Nermin , Uslu Tuğçe Nur , Kandemir Hakan , Atici Esen Bellur , ÖZPOLAT Bülent , AY Mehmet
Published: December 2020

Eukaryotic elongation factor 2 kinase (eEF2K) is an unusual alpha kinase whose expression is highly upregulated in various cancers and contributes to tumor growth, metastasis, and progression. More importantly, expression of eEF2K is associated with poor clinical outcome and shorter patient survival triple negative breast cancer (TNBC). Therefore, eEF2K is an emerging molecular target for development of novel targeted therapeutics and precision medicine in solid cancers. However, currently potent, and specific inhibitors of eEF2K are not available for clinical translation. In the current study, we investigated the effects of various newly designed and synthesized a series of compounds with coumarin scaffold substitutions in inhibiting eEF2K activity using in silico approaches and in vitro studies in TNBC cells. We utilized an amide substitution at 3-position on the coumarin ring with their pharmacologically active groups containing pyrrolidine, piperidine, morpholine and piperazine groups with –(CH2)2– bridged for aliphatic amides. To evaluate substituent effects on coumarin scaffold, boronic acid pinacol ester and boronic acids on phenyl rings were investigated using in silico and in vitro analyses. Due to their ability to form covalent binding to the target enzyme, we investigated the effects of boron containing groups on functionalized coumarin ring (3 compounds) and designed novel aliphatic and aromatic derivatives of coumarin scaffolds (10 compounds) and phenyl ring with boron groups (4 compounds). In silico analysis and molecular docking studies were performed using the Glide/SP module of Maestro molecular modeling package. According to obtained results, structure activity relationship (SAR) was carried out. Among the newly designed, synthesized, and tested compounds, our in vitro findings revealed that several compounds displayed a highly effective eEF2K inhibition at submicromolar concentration in in vitro breast cancer cells. In conclusion, we identified novel eEF2K inhibitors as promising anticancer drug substance candidates which should be further evaluated by in vivo studies, preclinical and clinical studies.
Isomerization and Fragmentation Reactions on the [C2SH4] Potential Energy Surface. The Metastable Thione-S-Methylide Isomer
Authors: Salta Zoi , Segovia Marc E. , Katz Aline , Tasinato Nicola , Barone Vincenzo , Ventura Oscar
Published: December 2020

Thione S-methylide (TSM), the parent species of the thiocarbonyl ylide family, is a 1,3-dipolar, planar species on the [C2SH4] potential energy surface (PES), which has not shared the richness of studies dedicated to its isomers, the cyclic thiirane (THI), and the keto-enol pair vinyl thiol (VTH)/thioacetaldehyde (THA). While the conrotatory ring closure reaction toward THI was studied in the ‘90s, no complete analysis of the PES is available in the literature. In the present paper, we report a computational study of the reaction scheme linking all species on that PES. We employ several levels of calculation, ranging from density functional theory (DFT), through CCSD(T) based composite schemes, to CASSCF/CASPT2 multi-reference procedures, to find the best description of TSM, its isomers, and the transition states (TSs) ruling their interconversion. Fragmentation of TSM, THA and THI were investigated and compared to the available experimental information. We found that the B2PLYP-D3 functional, contrary to M06-2XD3 or B97X-D, describes well the geometry of both TSM and the transition state connecting it to THI. The reverse barrier, from THI to TSM, amounts to 52.2 kcal mol-1 (to be compared to 17.6 kcal mol-1 for the direct one), thus explaining why, in general, thiocarbonyl ylides cannot be prepared from thiiranes. Conversion of THI to VTH implies also a large barrier, explaining why the reaction has been observed only at high temperatures. The fragmentation of THI to S(3P) or S(1D) and ethylene was also explored, together with the decomposition to H2S plus acetylene. Open species, both in triplet and singlet states, were identified as intermediates in the fragmentations, and their energies were found to be lower than the transition state for the isomerization of THI to VTH, thus explaining the preference for fragmentation over isomerization at relatively low temperatures.
Unraveling the Growth Mechanism of Magic-Sized Semiconductor Nanocrystals
Authors: Mule Aniket S. , Mazzotti Sergio , Rossinelli Aurelio A. , Aellen Marianne , Prins P. Tim , van der Bok Johanna C. , Solari Simon F. , Glauser Yannik M. , Kumar Priyank V. , Riedinger Andreas , Norris David J.
Published: December 2020

Magic-sized clusters (MSCs) of semiconductor are typically defined as specific molecular-scale arrangements of atoms that exhibit enhanced stability. They often grow in discrete jumps, creating a series of crystallites, without the appearance of intermediate sizes. However, despite their long history, the mechanism behind their special stability and growth remains poorly understood. This is particularly true considering experiments that have shown discrete evolution of MSCs to sizes well beyond the “cluster” regime and into the size range of colloidal quantum dots. Here, we study the growth of these larger magic-sized CdSe nanocrystals to unravel the underlying growth mechanism. We first introduce a synthetic protocol that yields a series of nine magic-sized nanocrystals of increasing size. By investigating these crystallites, we obtain important clues about the mechanism. We then develop a microscopic model that uses classical nucleation theory to determine kinetic barriers and simulate the growth. We show that magic-sized nanocrystals are consistent with a series of zinc-blende crystallites that grow layer by layer under surface-reaction-limited conditions. They have a tetrahedral shape, which is preserved when a monolayer is added to any of its four identical facets, leading to a series of discrete nanocrystals with special stability. Our analysis also identifies strong similarities with the growth of semiconductor nanoplatelets, which we then exploit to increase further the size range of our magic-sized nanocrystals. Although we focus here on CdSe, these results reveal a fundamental growth mechanism that can provide a different approach to nearly monodisperse nanocrystals.
Effect of Organisational Development and Career Paths on Organisational Commitment and Civil Servant Performance at Hasanuddin University
Authors: Sarivina Nusu Nur Ina , Yusuf Ria Mardiana , Maming Jumidah
Published: December 2020

Human resource management is a strategic and decisive part. The organization and employees are one unit that has a relationship and must be balanced. To be able to support the achievement of organizational goals requires effort and hard work of all aspects of organizational resources to achieve organizational goals and objectives. The purpose of this study was to determine the effect of organizational development and career paths on organizational commitment and employee performance, organizational development, and career paths have an effect on employee performance through organizational commitment as an intervening variable. This research is a quantitative descriptive study. The sample used is civil servants (PNS), data collection techniques through questionnaires, while the techniques used are path analysis and Sobel test. The results showed that the organization and career path had a positive and significant effect on organizational commitment and employee performance. Organizational commitment has an effect on performance, then organizational development and career path have a positive and significant indirect effect on employee performance through organizational commitment in the Rector of Hasanuddin University.
ANALISIS LETAK SUMBER AIR RUMAH TANGGA DI WILAYAH KERJA PUSKESMAS MIJEN, SEMARANG TERHADAP BAKTERI ESCHERICHIA COLI
Authors: Ratnaningrum Kanti , Anggraini Merry Tiyas , Dahlan Pujangga P.Y.
Published: December 2020

Latar belakang: Angka temuan kasus diare di wilayah kerja Puskesmas Mijen, Semarang masih relatif tinggi. Salah satupenyebab penyakit diare adalah kondisi air yang tercemar sumber pengotoran seperti dekatnya jarak sumber air denganseptic tank. Escherichia coli merupakan bakteri yang mungkin ditemukan pada air yang tercemar sumber pengotoran.Cakupan bidang kesehatan lingkungan dalam hal pengawasan dan pengendalian kualitas air di wilayah kerja PuskesmasMijen secara kseluruhan masih jauh dari capaian target, berdasarkan data tersebut maka perlu dilakukan penelitianmengenai analisis jarak septic tank dengan sumber air rumah tangga terhadap adanya bakteri Escherichia coli.Metode: Penelitian ini merupakan studi crossectional yang dilakukan di wilayah kerja Puskesmas Mijen. Pengambilansampel menggunakan metode systematic random sampling pada 10 kelurahan yang masuk dalam wilayah kerja denganpenentuan besaran sampel menggunakan rumus estimasi proporsi. Uji laboratorium kadar bakteri Escherichia colidalam air dilakukan di laboratorium Fakultas Kedokteran Universitas Muhammadiyah Semarang. Data dianalisismenggunakan uji chi square.Hasil: Dari 36 sampel air di dapatkan hasil tidak terdapat hubungan yang signifikan antara jarak septic tank dengansumber air rumah tangga terhadap adanya bakteri Escherichia coli (P-value = 0,2).Kesimpulan: Jarak septic tank dengan sumber air rumah tangga tidak berhubungan dengan temuan bakteri Escherichiacoli pada air rumah tangga di wilayah kerja Puskesmas Mijen.Kata kunci: air rumah tangga, septic tank, Escherichia coli
Kajian Tentang Efek Pemberian Nutrisi Kedelai (Glicine max) Terhadap Penurunan Kadar Kolesterol Total Pada Menopause
Authors: Setyawan Febri Endra Budi
Published: December 2020

Latar belakang: Kadar kolesterol darah yang meningkat merupakan resiko terjadinya arterosklerosis pada penyakit pada jantung koroner. Wanita menopause mempunyai kadar estrogen yang sangat rendah, sehingga menyebabkan peningkatan faktor resiko profil lipid. Kedelai memiliki kadar protein yang tinggi, yaitu rata-rata 35%, bahkan pada varietas unggul dapat mencapai 40-44%. Protein kedelai memiliki susunan asam amino esensial lengkap, serta daya cerna yang sangat baik. Kandungan asam amino pada kedelai terutama adalah metionin dan sistein, sedangkan kandungan lisin dan treonin sangat tinggi.Lemak kedelai mengandung asam lemak esensial yang cukup, yaitu asam linoleat (omega-6) serta asam linolenat (omega-3) sehingga memberikan pengaruh yang sangat berarti bagi kesehatan, khususnya dalam kaitannya dengan pengendalian kolesterol dan penyakit kolesterol dan penyakit kardiovaskuler.Mekanisme penurunan kolesterol oleh kedelai disebabkan oleh isoflavon yang mempunyai sifat estrogenik, sehingga terjadi penurunan LDL, TG dan kenaikan dari HDL dan akhirnnya terjadi penurunan kadar kolesterol total dalam darah. Ada berbagai macam faktor yang mempengaruhi asupan kedelai terhadap penurunan kolesterol total. Faktor-faktor yang mempengaruhi asupan kedelai dalam penurunan kolesterol total adalah bentuk dan jenis isoflavon, kadar asupan isoflavon, waktu penelitian,gender dari subjek, kadar lipid serta status dari menopause.Kata kunci: Kadar kolesterol, kedelai, menopouse
PENGARUH KONSUMSI KOPI TERHADAP PENINGKATAN TEKANAN DARAH
Authors: Amaluddin Nurlatifah Almaida , Malik Ummu Kalzum
Published: December 2020

Kopi merupakan minuman yang sejak lama digemari masyarakat Indonesia. Kopi dapat mempengaruhi tekanan darah karena kandungan polifenol, kalium dan kafein. Polifenol dan kalium bersifat menurunkantekanan darah, sedangkan kafein bersifat meningkatkan tekanan darah. Penelitian ini bertujuan untuk mengetahui adakah perubahan status tekanan darah setelah diintervensi yang diberikan dalam penelitianini yaitu  kopi. Desain penelitian merupakan penelitian observasional analitik dengan metode cross sectional study. Besar sampel yang digunakan sebanyak 96 laki-laki, dengan usia 20-40 tahun melalui tehnik purposive sampling. Hasil uji statistik dengan menggunakan uji Kolmogorov Smirnov, untuk pengaruh jenis kopi terhadap peningkatan tekanan darah  didapatkan nilai p = 1.000, pengaruh jumlah kopi terhadap peningkatan tekanan darah  didapatkan nilai p = 1.000 dan pengaruh frekuensi kopi terhadap peningkatan tekanan darah nilai p = 1.000, didapatkan secara statistik dapat disimpulkan bahwa tidak terdapat pengaruh konsumsi kopi terhadap peningkatan tekanan darah.Kata Kunci : Konsumsi Kopi, Peningkatan Tekanan Darah
PERKEMBANGAN SEL LIMFOSIT B DAN PENANDANYA UNTUK FLOWCYTOMETRY
Authors: Levani Yelvi
Published: December 2020

Sel limfosit B merupakan bagian dari respon imunitas adaptif yang berperan penting untuk pertahanan tubuh melawan patogen. Perkembangan sel limfosit B dimulai dari sel punca hematopoietik di sumsum tulang belakang dan organ limfoid sekunder dengan melalui berbagai tahapan proses maturasi dan seleksi. Sel limfosit B matur dapat menghasilkan berbagai macam antibodi yang spesifik untuk patogen. Di tiap perkembangannya, sel limfosit B memiliki ekspresi molekul yang berbeda pada permukaannya dan dapat diketahui dengan pemeriksaan flowcytometry. Pemeriksaan sel limfosit B yang sesuai dengan tahapan perkembangannya dapat digunakan untuk membantu diagnosis penyakit defisiensi imun kongenital, leukemia,limfoma dan penyakit autoimun. Kata kunci: Limfosit B, perkembangan, penanda, flowcytometry
Mekanisme Regenerasi Hati secara Endogen pada Fibrosis Hati
Authors: Safithri Fathiyah
Published: December 2020

Hati merupakan organ unik yang mempunyai kemampuan regenerasi yang luar biasa. Kemampuan regenerasi ini terjadi sepanjang usia manusia. Terapi fibrosis hati  yang berkembang saat ini lebih banyak terfokus pada bagaimana mengobati sel/ jaringan yang sakit berdasarkan patogenesis dan melupakan potensi sel-sel sehat. Sel sehat ini masih mempunyai potensi untuk regenerasi dan memperbaiki daerah yang sakit. Bila kedua hal ini dapat dilakukan bersama-sama maka akan mempercepat proses regenerasihati. Artikel ini akan mengeksplorasi kontribusi hepatosit, sel stelata, sel punca endogen, sel Kupfer, dan enzim proteolitik pada proses homeostasis dan perbaikan hati khususnya pada kondisi fibrosis.
DAFTAR ISI
Authors: DAFTAR ISI DAFTAR ISI
Published: December 2020

DAFTAR ISI
John Rawls’s Concept of Justice as Fairness
Authors: Edor Edor J.
Published: December 2020

John Rawls's theory of Justice is one of the most influential conceptions of justice. Scholars have continued to study it to understand the principles in the formation and to further frame it in the context of contemporary situations. This paper contributes to the ongoing discussion by presenting Rawls’ concept of “justice as fairness” as it evolved from the traditional conception of justice to the modern-shift in the concept. The paper also examines Rawls’s concept of justice as fairness, and it focuses on analyzing or studying the concept of justice as fairness in terms of the principles used in its formulations. Several criticisms developed by political philosophers to critique the idea were examined. In conclusion, it was argued that Rawls's invention of the veil-of-ignorance for the original position has affected the theory negatively.
The stylistic and poetical-compositional system of a fairy tale. Volume 2 : Poetic-compositional and stylistic system of a fairy tale in comprehensive
Authors: Adleyba Dzhulyetta
Published: December 2020

In the present edition “The stylistic and poetical-compositional system of a fairy tale” in 2 volumes, the author's works in the field of the study of the stylistic system of a fairy tale, carried out within the framework of an experimental direction in folklore studies, are combined. The study of the problem in this direction was undertaken by the author on the initiative of the outstanding scientist V.M. Gatsak, Doctor of Philology, Corresponding Member RAS, and was conducted over a number of years. In the monograph “Poetic-compositional and stylistic system of a fairy tale in comprehensive coverage of the problem. Experimental research based on abkhaz material”, which compiled the 2nd volume of this edition, the author highlights aspects of the heritability of a fairy tale and its recreation by folklore performers. The levels and factors of the compositional and stylistic structure of a fairy tale as a morphological reality with a comprehensive study of the stylistic (verbal and non-verbal) of its manifestations are analyzed. The section “Appendices” contains synopsis sheets of the narrative space of the investigated text collections of fairy tales.
THE ECOLOGICAL HOSTS SHIFT OF PARASITES AND THE OUTBREAK OF EMERGING INFECTIOUS DISEASES: A REVIEW
Authors: Legas Mohammed Seid
Published: December 2020

Parasites are organisms which metabolically depend upon their hosts. To understand the ecological host shift of a parasite, it is important to look the host-parasite associations with respect to ecological change and factors that generate, maintain, and constrain the associations with implications for a wide range of ecological issues, including the dynamics of emerging infectious diseases. Although, the ecological significance of   parasites is almost overlooked for several years by ecologists, considerable efforts are being made to understand their functional importance in ecosystems. Parasites play vital role in the trophic cascades of the food web. Environmental change caused by anthropogenic activities result host shift of specialist parasites and this shift of specialized parasites can rapidly to new hosts via ecological fitting play an important role in the ecology and evolution of host-parasite associations. This condition is the primary cause for the Emerging Infectious Diseases when parasite species begin infecting and causing disease in host species with which they have no previous history of association. Therefore, understanding the host parasites interaction and distribution of known and potential pathogens is a vital precondition for optimizing their positive, while minimizing their negative effects on conservation, restoration and sustained development programs.
KEPPRA (Levetiracetum) VS EPIVAL (Sodium Valporate) to control generalized tonic clonic seizures.
Authors: Farooq Fahad , Singh Gurdeep , Ahmad Farooq , Farooq Faizan , Farooq Faiq , Khurram Kashif Saleem , Younas Faisel , Singh Mimpal
Published: December 2020

Objective: This present study is design to assess the efficacy and frequency of side effects with a newer anti-epileptic agent levertiracetum while comparing an older anti-epileptic, Sodium Valproate, in the patients with generalized tonic colonic epilepsy. Material & Methods: Patients with GTC epilepsy had been allocated in two groups, A and B, Group A was given Sodium valproate while group B was given levertiracetum. Study Design: Randomized Control Trial. Setting: Fatima Memorial Hospital, Lahore and Allied Hospital, Faisalabad. Period: December, 2017 to December, 2018. Results: Seventy five subjects were taking levertiracetum from three months out of which 56(74.7%)were seizures free, 15(20%) were seizure free on higher dose,6(8%) were with dizziness ,vertigo and 9(12%) were with somnolence. Fifty-four individuals were seizures free with normal dose of sodium valproate from last 3 months, and 16(21%) were seizures free on higher doses among which 53(70%) were with side effects of weight gain and 69(92%) were with hand tremors and this was the most prominent side effects among individuals who were taking sodium valproate. Conclusion: Generalized tonic colonic epilepsy is one of the most common forms of epilepsy and with the advent of newer anti-epileptic drugs like levertiracetum, such seizures can be controlled in with lesser side effects as compared to older antiepileptic agent Sodium Valproate.
Role of lifestyle in the development of Cardiovascular diseases among the workers working in the offices.
Authors: Mehboob Qamar , Arif Waqar , Arif Sana
Published: December 2020

Objectives: The incidence of coronary heart disease in Pakistan is not well established. While the role of lifestyle risk factors and job-related conditions in the development of such diseases, still needs more clarification. Study Design: Cross-sectional study. Settings: Faisalabad Medical University, Faisalabad. Period: Jan, 2018 – Dec, 2018. Material & Methods: 30 office workers of FMU were approached including males & females. A semi-structured questionnaire was used. For evaluation of habitual physical activity Baecke questionnaire was used. Results: 30 office workers of FMU of age groups ranging from 20 above to 59 years (37.333±12.103) were being studied. A questionnaire to evaluate lifestyle and awareness of cardiovascular diseases and risk factor profile and prevalence was administrated to the participants with 23 males and 7 females. Among all, reported smokers were 19%. 47% participants had never performed exercise, overall statistical analysis for physical exercise was 1.4000 ± 0.62146, df =29, p ˂ 0.000, 95% CI. Job strain intensity was assessed according to Job Strain Index (JSI) Scale. It was reported that 53% workers had hard intensity while overall we found JSI 3.3333 ± .75810, df=29, p ˂ 0.000, 95% CI. Conclusion: Some flexibility regarding their job, proper awareness about Cardiovascular Diseases (CVDs) and their risk factors is the need of the day.
To determine the frequency of intracerebral haemorrhage (ICH) in patients taking antiplatelet therapy.
Authors: Shehbaz Lal , Nasir Shua , Khan Abdul Naveed
Published: December 2020

Objectives: To determine the frequency of Intracerebral Haemorrhage (ICH) in patients taking antiplatelet therapy. Study Design: Cross-Sectional Study. Setting: Emergency Department at Ziauddin Hospital. Period: 2014-2016. Material & Methods: A total number of 75 patients with ICH, diagnosed by C.T Scan Brain Plain were included in this study. After the diagnosis of ICH on C.T scan Brain, patients were selected as with prior use of antiplatelets or secondary to other causes. Brief history was taken from the patients and attendants regarding the history of antiplatelets use. Results: The average ages of the patients were 59.97±12.46 years. There were 57.33% male and 42.67% female.  Out of 75 ICH patients 44% (33/75) were taking antiplatelet therapy. Median duration of APT was 12[IQR=24] months. Out of these 33 patients 78.8% (26/33) were taking single APT and 21.2% (7/33) were taking dual APT.  Mean age was significantly high in patients those who are on antiplatelet therapy as compare to those who was not on APT (p=0.033). Gender and systematic finding of patients were not significant those who are not on APT and on APT.  Comorbid like DM, HTN and IHD were significant high in patients on APT and in hospital mortality was also not significant in patients on APT and not on APT. Conclusion: In this study overall in hospital mortality was observed in 13.33%. These study suggests there is only modestly increased mortality in patients taking pre-ICH APT, and little or no increase in poor functional outcomes there are a substantial number of ICH patients taking pre-ICH APT who could be at risk. The pre-ICH APT mortality is correlated, which can be improved by therapies to restore normal platelet function which is uncertain and to demonstrate needs comparatively large trials, given the modest increase in risk. For the reduction in morbidity related to APT-ICH Prevention of risk factor like HTN is most antonyms strategy.
Prevalence of vitamin D inadequacy in asymptomatic population.
Authors: Jabbar Asifa Abdul , Unar Fozia , Khan Fiza Ali , Karamat Shahida , Khokhar Naeem Akhter , Memon Asghar
Published: December 2020

Objectives: The aim of study was to determine vitamin d deficiency in age and sex groups associated with different regions. Therefore, this diagnostic method has played an important role in the prevention of various medical conditions. Study Design: Cross-sectional study. Setting: Department of Obstetrics and Gynaecology, Gambat Institute of Medical Sciences Gambat, Khairpur Sindh. Period: 14 August 2016 to 24 February 2018. Material & Methods: Total 1924 participants were screened and included in the study by fulfilling the inclusion criteria. Exclusion criteria were signs and symptoms of any chronic disease, active injury, abnormal liver function or any chronic kidney and pregnancy problem. All participants who met the inclusion and exclusion criteria were interviewed after taking informed consent. Questionnaires for the study were prepared and distributed to the selected population. According to the questionnaire and interviews by the researchers, details of lifestyles, social status, and monthly income were reported. Moreover, marital status, milk in take, and sun exposure hours were also asked. Blood sample of each participant was taken after taking written informed consent form. A total 1924 people screened for Vitamin D levels with help of direct chemiluminescence using ADVIA Centaur assay. Results: 1924 people from five different regions of Gambat. A total of 1153 (59.9%) people with vitamin D deficiency were found, while 724 showed normal rates and 47 found to be larger than normal. Females are more deficient for vitamin D (35.7%) than males (24.4%). Conclusion: The high population without symptoms with low levels Vitamin D is an alarming sign of deteriorating health, while multiple risk factors appear.
Monitoring Water Spread and Aquatic Vegetation using Spectral Indices in Nalsarovar, Gujarat State-India
Authors: Chauhan Kirtan , Patel Jinal , Shukla Shital H. , Kalubarme Manik H.
Published: December 2020

Nalsarovar Bird Sanctuary, a natural freshwater lake (a relict sea) that is the largest natural wetland in the Thar Desert Bio-geographic Province and represents a dynamic environment with salinity and depth varying depending on rainfall. For maintaining ecological balance in coastal and inland environments, wetlands play an important role and the changes in wetland environment can be monitored using satellite remote sensing technique. The present study was carried out using Landsat-7 TM (Feb-2002), Landsat-5 TM (Feb- 2009) and Sentinel-2 multi-spectral data (Feb-2018) covering Nalsarovar area in Ahmedabad district. The study area of Nalsarovar with 10 km buffer was extracted from the satellite digital data. Various spectral indices like Normalized difference Vegetation Index (NDVI), Normalized difference Water Index (NDWI) and Normalized difference Turbidity Index (NDTI) were generated for better identification and delineation of water body and aquatic vegetation in the Nalsarovar. The composite images of these indices were also generated to map and monitor changes in water spread and aquatic vegetation in the Nalsarovar. The water spread and aquatic vegetation in the Nalsarovar along with the land use classes were mapped using False Colour Composite (FCC) images of differed years.

The result indicates that the water spread in Nalsarovar has changed from 2002, 2009 and 2018 depending on the monsoon pattern during these years. During drought year of 2002 total precipitation was very less resulting drastic reduction in the water spread in Nalsarovar. The aquatic vegetation has changed from 146.81 ha during 2002 to 510.93 ha during 2018. The land use change indicates that agriculture land, built-up, water body & wetland has increased and barren land, salt affected area has decreased. The aquatic vegetation in Nalsarovar was clearly visible on composite images generated using NDVI, NDWI and NDTI of different years. This study gives clear idea for land use change detection and water spread monitoring using two different techniques using Composite image of NDVI, NDWI and NDTI.
IMPACT OF INTERLAMINAR ELLIPTICAL DEFECTS UPON BEHAVIOR OF RECTANGULAR CARBON PLASTIC PLATE AT STATIC AND DYNAMIC LOADS
Authors: Medvedskiy Aleksandr , Martirosov Mihail , Homchenko Anton , Dedova Darina
Published: December 2020

The purpose of this work is to investigate the impact of the inner defects of elliptical stratification type upon behavior of the rectangular carbon plastic plate at the impact of static and dynamic loads.

The investigation methods: the problem is solved in a numerical way with the aid of a finite ele-ment method (FEM) in the LS-DYNA software com-plex (Livermore Software Technology Corp.).

The investigation results: the distribution of stresses in plate layers under the impact of static and dynamic loads is obtained. The distribution of destruc-tion indices with the use of different destruction criteria for unidirectional composites (on the basis of carbon band) is defined.

Conclusions: the impact of defects of the type of specified shape stratification, dimensions, amount and places of location with regard to the plate under consideration under the action of compressive static load does not practically tell. Under the action of the compressive dynamic load there is observed a noticeable impact of inner defects upon rectangular plate behavior.
KEBUTUHAN STANDAR TEKNOLOGI HIPERSPEKTRAL DAN KESIAPAN TEKNOLOGINYA DI INDONESIA
Authors: Ayundyahrini Meilinda , Purwanto Endi Hari , Lukiawan Reza , Setyoko Ajun Tri
Published: December 2020

Hyperspektral merupakan teknologi yang memanfaatkan radiasi elektromagnetik dan cahaya. Teknologi ini dimanfaatkan dalam pemetaan bumi baik pada satelit maupun insitu. Selain hiperspektral, terdapat multi spketral yang memiliki perbedaan pada jumlah kanal (band) yaitu mencapai 100-500 band pada hiperspektral. Tingginya band ini menghasilkan data yang kaya informasi, spesifik dan detail. Sensor dapat menangkap reflektansi atau pantulan spektrum gelombang tampak yang kembali dari permukaan bumi. Kompleksitas dan beragamnya pengolahan hiperspektral berdampak pada akurasi citra yang berbeda-beda. Sampai saat ini belum ada prosedur atau standar yang berlaku secara internasional, namun beberapa instansi internasional telah mengarah pada penyusunan standar terkait. Mengingat teknologi dan pemanfaatan hiperspektral di dunia yang kembali berkembang, sehingga perlu disusun sebuah standar agar citra yang didapat memiliki tingkat akurasi yang baik dan layak dijadikan dasar kebijakan. Tentunya dalam penyusunan standar perlu diawali dengan mengetahui kesiapan standar dan persepsi stakeholder. Penelitian ini menggunakan metode deskriptif kuantitatif untuk menjelaskan fenomena yang terjadi dan analisa SWOT. Hasil dari penelitian ini menunjukkan bahwa perlu disusun standar pengukuran spektral dengan nilai 100%, standar kalibrasi peralatan dengan persentase setuju 93,3% dan rata-rata likert 4,47, dan komponen utama hiperspektral sebesar 93,3% dengan rata-rata likert 4,27. Responden yang menyampaikan bahwa Indonesia belum siap mengembangkan teknologi hiperspektral sebesar 72,86% dan 20% diantaranya harus segera memulainya. Urgensi penerapan hiperspektral di Indonesia adalah di bidang pertanian yang mana dapat mendukung precision agriculture dalam rangka mendukung program ketahanan pangan.
Visual Art in Counseling
Authors: Febiola Stefani Cindy
Published: December 2020

Bimbingan dan Konseling adalah proses interaksi konselor dengan konseli yang berjumlah paling sedikit 1 orang. Dalam melakukan bimbingan konseling, konselor harus menyiapkan program kegiatannya untuk konselinya agar bisa mencapai keinginan yang dia inginkan. Konselor harus tau apa aja sih yang menjadi kendala jika konselinya merasakan adanya kejanggalan dan juga harus tau bagaimana teknik yang harus ia gunakan untuk melakukan proses konseling agar bisa berhasil dengan tujuan yang konseli inginkan. Konseli harus paham dan mengerti bagaimana cara menggunakan teknik-teknik konseling yang ada. Hanya konselor yang pada saat kuliah jurusannya bimbingan dan konseling, tau dan paham apa saja yang harus dipersiapkannya dan apa yang harus dilakukannya selama konseling.
Target Learning in Event-Based Prospective Memory
Authors: Strickland Luke Joseph Gough , Heathcote Andrew , Humphreys Michael , Loft Shayne
Published: December 2020

Event-based prospective memory (PM) tasks require individuals to remember to perform a previously planned action when they encounter a specific event. Often, the natural environments in which PM tasks occur are embedded are constantly changing, requiring humans to adapt by learning. We examine one such adaptation by integrating PM target learning with the Prospective Memory Decision Control (PMDC) cognitive model. We apply this augmented model to an experiment that manipulated exposure to PM targets, comparing a single-target PM condition where the target was well learned from the outset, to a multiple-target PM condition with less initial PM target exposure, allowing us to examine the effect of continued target learning opportunities. Single-target PM accuracy was near ceiling whereas multiple-target PM accuracy was initially poorer but improved throughout the course of the experiment. PM response times were longer for the multiple- compared to single-target PM task but this difference also decreased over time. The model indicated that PM trial evidence accumulation rates, and the inhibition of competing responses, were initially higher for single compared to multiple PM targets, but that this difference decreased over time due to the learning of multiple-targets over the target repetitions. These outcomes provide insight into how the processes underlying event-based PM can dynamically evolve over time, and a modelling framework to further investigate the effect of learning on event-based PM decision processes.
Are the more flexible great-tailed grackles also better at behavioral inhibition?
Authors: Logan Corina J , McCune Kelsey , MacPherson Maggie , Johnson-Ulrich Zoe , Rowney Carolyn , Seitz Benjamin , Blaisdell Aaron , Deffner Dominik , Wascher Claudia A.F.
Published: December 2020

Behavioral flexibility (hereafter, flexibility) should theoretically be positively related to behavioral inhibition (hereafter, inhibition) because one should need to inhibit a previously learned behavior to change their behavior when the task changes (the flexibility component). However, several investigations show no or mixed support of this hypothesis, which challenges the assumption that inhibition is involved in making flexible decisions. We aimed to test the hypothesis that flexibility (measured as reversal learning and solution switching on a multi-access box by Logan et al. 2019) is associated with inhibition by measuring both variables in the same individuals and three inhibition tests (a go/no go task on a touchscreen, a detour task, and a delay of gratification experiment). We set out to measure grackle inhibition to determine whether those individuals that are more flexible are also better at inhibition. Because touchscreen experiments had never been conducted in this species, we additionally validated that a touchscreen setup is functional for wild-caught grackles who learned to use the touchscreen and completed the go/no go inhibition task on it. Performance on the go/no go and detour inhibition tests did not correlate with each other, indicating that they did not measure the same trait. Individuals who were faster to update their behavior in the reversal experiment took more time to attempt a new option in the multi-access box experiments, and they were either faster or slower to reach criterion in the go/no go task depending on whether the one bird, Taquito, who was accidentally tested beyond the 200 trial cap was included in the GLM analysis. While the relationship between the number of trials to reverse a preference and the number of trials to reach the go/no go criterion was strongly influenced by Taquito, who was very slow in both experiments, the more comprehensive Bayesian model of flexibility that takes all trials into account and does not rely on an arbitrary passing criterion provided support for the positive relationship irrespective of whether Taquito was included. Performance on the detour inhibition task did not correlate with either measure of flexibility, suggesting that detour performance and the flexibility experiments may measure separate traits. We were not able to run the delay of gratification experiment because the grackles never habituated to the apparatuses. We conclude that flexibility is associated with certain types of inhibition, but not others, in great-tailed grackles.
Does the privacy paradox exist? Comment on Yu et al.’s (2020) meta-analysis
Authors: Dienlin Tobias , Sun Ye
Published: December 2020

In their meta-analysis on how privacy concerns and perceived privacy risk are related to online disclosure intentionand behavior, Yu et al. (2020) conclude that “the ‘privacy paradox’ phenomenon (...) exists in our research model” (p. 8). In this comment, we contest this conclusion and present evidence and arguments against it. We find five areas of problems: (1) Flawed logic of hypothesis testing; (2) erroneous and implausible results; (3) questionable decision to use only the direct effect of privacy concerns on disclosure behavior as evidence in testing the privacy paradox; (4) overinterpreting results from MASEM; (5) insufficient reporting and lack of transparency. To guide future research, we offer three recommendations: Going beyond mere null hypothesis significance testing, probing alternative theoretical models, and implementing open science practices. While we value this meta-analytic effort, we caution its readers that, contrary to the authors’ claim, it does not offer evidence in support of the privacy paradox.
PATHOPHYSIOLOGICAL COMPONENTS OF ARTERIAL HYPERTENSION.PROSPECTS FOR PREVENTION AND REHABILITATION
Authors: Cherkasov A. , Petrova E.
Published: December 2020

The article provides a theoretical analysis of the causes of arterial hypertension, describes a 3month observation of the initial stage of the development of hypertension and experiments on non-drug normalization of blood pressure on a group of volunteers. We show that arterial hypertension is associated with spastic conditions of the intervertebral muscles in the lower thoracic spine, which leads to compression of sympathetic nerves that control the transport of water through the kidneys, which in turn upsets the balance of fluid circulation through the circulatory system.
Theoretical analysis and experimental data made it possible to formulate a hypothesis about the dominant role of disorders in the activity of the sympathetic part of the nervous system in the development of primary and persistent arterial hypertension. The possibility of prevention of arterial hypertension and non-drug rehabilitation of patients with this disease has been shown.
REGULATION OF BREATHING IN THE EXTENDED RANGE
Authors: Vasilyev G.
Published: December 2020

In modern physiology, very simplified perceptions of such an essential system for the body as the respiratory system have taken root. The system analysis showed that at a physical load of more than 50 W, the tissue respiratory subsystem is activated, providing a volume blood flow rate adequate to the amount of oxygen consumed, and in the external respiratory subsystem the regulation on oxygen voltage in arterial blood is activated, and the regulation on carbon dioxide voltage is deactivated. The role of respiratory frequency in increasing the rate of diffusion through the alveolar capillary membrane is shown.