bluuebunny/crossref_metadata_2025 huggingface dataset:
Distribution and volume of mitochondria in alveolar epithelial type 1 cells in infant and adult human lungs
Authors: Schierz Arne K. , Rößler Giacomo , Schneider Jan Philipp , Tschanz Stefan A. , Werlein Christopher , Jonigk Danny D. , Schipke Julia , Mühlfeld Christian
Published: November 2024

Alveolar epithelial type I (AE1) cells with their wide spatial expansion form approximately 95% of the outer surface area of the air-blood barrier inside the lung. Serial block-face scanning electron microscopy (SBF-SEM) investigations led to the hypothesis that AE1 cell mitochondria are preferentially distributed as aggregates in those parts of AE1 cells that are located above connective tissue pillars between capillaries, thus not increasing the thickness of the diffusion distance for oxygen and carbon dioxide. Furthermore, it was hypothesised that postnatal development requires adapting the amount and distribution of mitochondria in AE1 cells. Human lung samples from three infant (26 and 30 days, 6 months) and three adult (20, 39 and 40 years) samples were investigated by light microscopy, transmission electron microscopy and stereology. The volume fraction of mitochondria was similar in infant and adult lungs with a mean value of 6.3%. The ratio between mitochondrial profiles on top of capillaries or above connective tissue pillars was approximately 3:1 in infants and adults. However, regarding the volume of both cytoplasmic compartments, infants showed a higher number of mitochondrial profiles on top of capillaries while adults showed a higher number above connective tissue pillars. Samples of three additional adult lungs were analysed by confocal laser scanning microscopy. Again, mitochondria were not preferentially found as aggregates above connective tissue pillars. In conclusion, AE1 cell mitochondria were not preferentially found as aggregates, showed the same volume density in infants and adults but differed in distribution between the age groups.
Associations of physical activity and sedentary time with health-related quality of life in patients with localized renal cell cancer: a cross-sectional analysis within the ReLife study
Authors: Vrieling Alina , Maurits Jake S. F. , Gerritsen Job , Buffart Laurien M. , Aben Katja K. H. , Sedelaar J. P. Michiel , Bakker Esmée A. , Kiemeney Lambertus A. L. M.
Published: November 2024

Purpose

This study examined the associations of device-measured moderate-to-vigorous physical activity (MVPA) and sedentary time as well as self-reported MVPA with health-related quality of life (HRQoL) in patients with localized renal cell cancer (RCC) in the recovery phase after surgery.

Methods

At 3 months post-surgery, 341 patients with stage I-III RCC participating in the ReLife study wore an ActivPAL3 device to determine MVPA and sedentary time. The SQUASH questionnaire was used for assessing self-reported MVPA, and the EORTC QLQ-C30 for assessing HRQoL (range 0–100). Multivariable linear regression models were used to examine the cross-sectional associations of MVPA and sedentary time with HRQoL.

Results

The highest (≥ 6.7 h/week) versus lowest (≤ 2.7 h/week) quartile of MVPA was associated with a better global health status (β, 10.2; 95% CI, 5.1, 15.3), summary score (β, 4.6; 95% CI, 1.1, 8.1), physical (β, 7.7; 95% CI, 3.8, 11.6), role (β, 12.4; 95% CI, 4.7, 20.2), and social functioning (β, 7.3; 95% CI, 0.2, 14.4), and lower fatigue (β, − 11.2; 95% CI, − 18.1, − 4.2). Results for self-reported MVPA were in the same direction but weaker. The lowest (≤ 8.8 h/day) versus highest (≥ 11.5 h/day) quartile of sedentary time was associated with better physical functioning (β, 4.6; 95% CI, 0.8, 8.5).

Conclusions

In patients with localized RCC, higher MVPA 3 months post-surgery was associated with better HRQoL outcomes including less fatigue whereas lower sedentary time was only associated with better physical functioning. This information can contribute to the development of physical activity guidelines and interventions to improve HRQoL.
Survivorship care plans and adherence to breast and cervical cancer screening guidelines among cancer survivors in a national sample
Authors: Santos-Teles Marco , Modugu Ganesh , Silva Isabel C. , Bandera Elisa V. , George Mridula , Qin Bo , Smith Jonathan , Stephenson Ruth , Mattes Malcolm D. , Eskander Mariam F.
Published: November 2024

Purpose

The impact of the components of survivorship care plans on adherence to cancer screening guidelines among cancer survivors is limited. We examined the association of receipt of treatment summaries, follow-up instructions, and type of doctor providing survivorship care with adherence to breast cancer screening (BCS) and cervical cancer screening (CCS) guidelines in female cancer survivors.

Methods

A cross-sectional analysis using Behavioral Risk Factor Surveillance System (BRFSS) data from 2014, 2016 and 2018 was conducted. BCS and CCS-eligible women were aged 40–74 and 30–64, respectively. BCS adherence was defined as a mammogram within 2 years and CCS adherence as a pap smear within 3 years or HPV test within 5 years. Univariate analysis with chi-square and multivariable logistic regression are reported.

Results

5,001 BCS and 3,014 CCS-eligible survivors were identified. In the BCS group, recipients of treatment summaries and follow-up instructions were significantly more adherent with BCS (84.1% vs. 77.4%; 83.4% vs. 74%, respectively, p < 0.001). In the CCS group, recipients of follow-up instructions were significantly more adherent with CCS (78.1% vs. 67.7%, p < 0.001). In both groups, there was no significant difference in BCS or CCS based on type of physician providing care (p = 0.087). On multivariate analysis, receipt of follow-up instructions was the only factor significantly associated with BCS (OR:2.81; 95%CI:1.76–4.49) and CCS (OR:3.14; 95%CI:1.88–5.23).

Conclusions

Follow-up instructions, as part of survivorship care plans, have the strongest association with BCS and CCS among female cancer survivors. Additional research should focus on improving the distribution of survivorship care plans, particularly follow-up instructions, as a method to increase BCS and CCS among cancer survivors.
Long-term outcomes following posterior fossa decompression in pediatric patients with Chiari malformation type 1, a population-based cohort study
Authors: El-Hajj Victor Gabriel , Öhlén Erik , Sandvik Ulrika , Pettersson-Segerlind Jenny , Atallah Elias , Jabbour Pascal , Bydon Mohamad , Daniels David J. , Elmi-Terander Adrian , Edström Erik
Published: November 2024

Objective

Posterior fossa decompression for Chiari malformation type I (Chiari 1) is effective and associated with a low risk of complication. However, up to 20% of patients may experience continued deficits or recurring symptoms after surgical intervention. For pediatric patients, there are no established tools to predict outcomes, and the risk factors for unfavorable postoperative outcomes are poorly understood. Hence, our aim was to investigate baseline data and early postoperative predictors of poor outcomes as determined by the Chicago Chiari outcome scale (CCOS).

Methods

All pediatric patients (< 18 years) receiving a posterior fossa decompression for Chiari 1 between the years of 2005 and 2020 at the study center were eligible for inclusion. Patients with congenital anomalies were excluded.

Results

Seventy-one pediatric patients with a median age of 9 years were included. Most patients (58%) were females. Chiari 1 was associated with syringomyelia (51%), scoliosis (37%), and hydrocephalus (7%). Perioperative complications occurred in 13 patients (18%) of which two required additional procedures under general anesthesia. On multivariable proportional odds logistic regression, motor deficits (OR: 0.09; CI95%: [0.01–0.62]; p = 0.015), and surgical complications (OR: 0.16; CI95%: [0.41–0.66]; p = 0.011) were significant predictors of worse outcomes. The presence of syringomyelia was identified as a predictor of better outcomes (OR: 4.42 CI95% [1.02–19.35]; p = 0.048). A persistent hydrocephalus during the early postoperative period after posterior fossa decompression was a strong predictor of worse long-term CCOS (OR: 0.026; CI95%: [0.002–0.328]; p = 0.005).

Conclusion

Results from this study indicate that the existence of motor deficits and syringomyelia prior to surgery, and surgical complications and persistent hydrocephalus despite posterior fossa decompression, were useful predictors of long-term outcome.
Generations of ‘shock absorbers’: women caregivers of young children and their efforts to mitigate food insecurity during the COVID-19 pandemic
Authors: Lindberg R. , Parks C. , Bastian A. , Yaroch A. L. , McKay F. H. , van der Pligt P. , Zinga J. , McNaughton S. A.
Published: November 2024

Despite their status as high-income food producing nations, children and their caregivers, both in the United States (U.S.) and Australia can experience food insecurity. Nutrition researchers formed a joint U.S.-Australia collaboration to help advance food security for households with young children aged 0–5 years. This study investigated food insecurity from the perspective of caregivers, especially their perceptions of the impact of food insecurity on their own childhood, their current life, and for the children in their care. Semi-structured interviews were conducted from July to September 2020 during the COVID-19 pandemic. Participants were recruited in Omaha, Nebraska, U.S. (n = 19) and Melbourne, Victoria, Australia (n = 22), during periods of stay-at-home public health orders. These two case study sites enabled an exploration of some universal, and some context-specific, social, economic, and health conditions that buffer, or exacerbate, food insecurity for families in these neo-liberal political settings. An inductive thematic analysis was conducted and established six themes:growing up poor, lessons learned, feeding a family amidst a pandemic, caregiver coping strategies, food security in the early years and protecting (young) children. Perspectives on local anti-hunger strategies were organized to outline participant’s preferred solutions. Household food insecurity is conceptualized in public policy in the U.S. and Australia as a short-term crisis for people, justifying austere, time-limited and patchwork solutions. A narrative of caregivers’ lived experience of food insecurity suggests that it is inter-generational, and exacerbated by a food system shock (i.e., COVID-19). These findings from two varying cities and nations offer a different conceptualization of the timespan and nature of the phenomenon of food insecurity, challenging a dominant policy narrative and highlighting the inadequacy of current so-called solutions.
Ichthyobodo necator infection as a first record in cultured Dicentrarchus labrax: morphomolecular characterization and infestation patterns in correlation to water quality parameters
Authors: Fadel Amr , Abdelsalam Khaled M. , Thabet Walaa M. , Bessat Mohamed
Published: November 2024

Ichthyobodo necator is a damaging and economically important protozoan parasite; however, its clinical patterns and incidence, correlated to environmental factors, are still poorly understood. This study provides the first report of Ichthyobodo necator infestation among Dicentrarchus labrax. We recorded significant mortalities in the cultured D. labrax of average size (5.92 g weight, and 11.55 cm length) in El-Max Station, National Institute of Oceanography and Fisheries, NIOF, Egypt, during the period extending from early summer to early fall (June to October) 2023. Behavioral and gross lesions of the infested fish were recorded; besides, dead and moribund fish were collected. Wet smears of the skin and gill of the affected fish were examined by compound light microscopy. Moreover, water samples from the affected ponds were collected and examined for their physicochemical parameters. The bodonid biflagellated Ichthyobodo necator (Henneguy) C. Pinto, 1928 was isolated from the skin and gills and identified based on specific morphological characteristics. DNA sequencing of PCR products and phylogenetic analysis confirmed identification, with clustering of the current isolates with I. necator isolates from different fish species. The multivariate analysis revealed a positive correlation between the prevalence and infestation intensity of Ichthyobodo, increased temperature levels, decreased dissolved oxygen DO, and also correlated with higher ammonia, and pH values. Additionally, the elevated concentrations of iron, calcium, magnesium, zinc, and copper in pond water were positively correlated with infestation and mortalities. These water parameter levels promote respiratory distress, accelerated prevalence, and infestation intensities of I. necator, particularly during the infestation peak in August and September. This study bridges the knowledge gap regarding I. necator parasite infestations and their correlation with water quality parameters.
Frogs recognize prey: a causal-behavioral teleosemantics
Authors: Withrington Esteban
Published: November 2024

I propose a version of teleosemantics for simple animal representations that combines Millikan’s suggestion that they represent the most crucial “normal conditions” required for them to bring about their beneficial behavioral effects with Neander’s suggestion that they represent their “normal causes”. The content of a simple representation is the most crucial among the normal conditions responsible for its tokens having beneficial behavioral effects that also causes such tokens. I argue that this version delivers more plausible contents than other versions of teleosemantics. Frogs’ prey detectors represent the animals they prey on rather than nutritious or small moving things.
Associations Between Interpersonal Trauma and Intolerance of Uncertainty in an International Multi-Site Sample
Authors: Morriss Jayne , Rosenek Norma , Gaudiano Brandon A. , So Suzanne H. , Kingston Jessica , Lincoln Tania , Morris Eric M.J. , Ellett Lyn
Published: November 2024

Prior psychologically traumatic experiences have been linked to increased risk for mental health conditions. However, there remain questions about the relationship between prior interpersonal trauma, particularly that of neglect and abuse, and transdiagnostic dimensions such as intolerance of uncertainty (IU: the tendency to find uncertainty aversive). To address this gap, we conducted a secondary analysis of survey data from an international multi-site sample (n = 2510). Questionnaires included: Interpersonal trauma by type (e.g. emotional neglect, physical abuse, psychological abuse, sexual abuse) and IU. The findings revealed that: (1) experiencing different forms of interpersonal trauma was associated with higher IU, and (2) experiencing multiple forms of neglect and abuse was associated with higher IU. When comparing across the interpersonal trauma types and IU, emotional neglect compared to the other types of abuse, was specifically related to higher IU. These effects remained when controlling for broader negative beliefs about the self and others. However, the observed relationships and overall amount of variance explained by IU was rather small. Overall, these findings demonstrate that interpersonal trauma, particularly emotional neglect, is associated with IU. Future longitudinal research is required to examine if, how, and when after adversity, higher IU may emerge.
Constructing Closeness in Educational Collaboration in Extended Hours ECEC
Authors: Peltoperä Kaisu , Rautamies Erja , Lang Sarah N.
Published: November 2024

Although quality early childhood education and care (ECEC) and strong collaborations between families and ECEC educators are important for all children, they may be particularly important for children and families who utilize nighttime or weekend ECEC. This study focuses on ECEC educators’ discourses about closeness versus distance in educational collaborations between parents with nonstandard schedules and professionals who work in extended hours ECEC. The data for this study were collected by interviewing ECEC teachers (n = 12) and nurses (n = 18) working in Finland. Research findings: Using the principles of discourse analysis, we found three tensional discourses: (a) the timing of ECEC and asynchrony; (b) a sense of time versus hurry; and (c) care versus criticism. Practice and policy: The findings revealed that extended hours ECEC provides both challenges and possibilities for creating close educational collaboration with parents. This has important implications for the kinds of structural supports and training educators in extended hours ECEC may need to foster quality collaboration with families.
A Spectral Element Solution of the Poisson Equation with Shifted Boundary Polynomial Corrections: Influence of the Surrogate to True Boundary Mapping and an Asymptotically Preserving Robin Formulation
Authors: Visbech Jens , Engsig-Karup Allan P. , Ricchiuto Mario
Published: November 2024

We present a new high-order spectral element solution to the two-dimensional scalar Poisson equation subject to a general Robin boundary condition. The solution is based on a simplified version of the shifted boundary method employing a continuous arbitrary order hp-Galerkin spectral element method as the numerical discretization procedure. The simplification relies on a polynomial correction to avoid explicitly evaluating high-order partial derivatives from the Taylor series, which traditionally is used within the shifted boundary method. Here, we apply an extrapolation and novel interpolation approach to project the basis functions from the true domain onto the approximate surrogate domain. The solution provides a method that naturally incorporates curved geometrical features of the domain, overcomes complex and cumbersome mesh generation, and avoids problems with small cut cells. Dirichlet, Neumann, and Robin boundary conditions are enforced weakly through a generalized: (i) Nitsche’s method and (ii) Aubin’s method. A consistent asymptotic preserving formulation of the embedded Robin formulations is presented. Several experiments and analyses of the numerical properties of the various weak forms are showcased. We include convergence studies under polynomial increase of the basis functions, p, mesh refinement, h, and matrix conditioning to highlight the spectral and algebraic convergence features, respectively. With this, we assess the influence of errors across variational forms, polynomial order, mesh size, and mappings between the true and surrogate boundaries.
Introduction: The ‘functional ideal of truth’ — A new key for Cassirer research
Authors: Endres Tobias , Truwant Simon
Published: November 2024

This special issue focuses on two related topics in Ernst Cassirer’s thought: objectivity and truth. Through this lens, the guest editors attempt to illuminate (a) the historical and systematic value of Cassirer’s philosophical project, (b) the continuing relevance of his account of the plurality and universality of human understanding in view of the crisis of truth that currently permeates Western culture, and (c) the way Cassirer’s style can inspire contemporary scholars who wish to evade the analytic-continental divide. Tobias Endres and Simon Truwant gathered twelve contributions from more analytic oriented authors from the philosophy of science and more continental oriented authors from the philosophy of culture. By bringing these scholars together on a shared topic, they hope to help bridging this divide that is also reflected within Cassirer scholarship by preoccupation with either his philosophy of science or philosophy of culture. The articles in this special issue are preceded by a ceremonial speech that Cassirer gave on the occasion of his assumption of the rectorate of the University of Hamburg on November 7, 1929 and that was translated into English for the first time by the guest editors.
What is conceptual hypocrisy? Is it problematic?
Authors: Ye Xindi
Published: November 2024

In conceptual engineering, a hypocritical argument is an argument that uses a concept to argue against the use of that very concept (Burgess and Plunkett 2013; Burgess 2020). Call this sort of hypocrisy ‘conceptual hypocrisy’. Should we accept conceptual hypocrisy? My response has a negative and a positive part. In the negative part, I review attempts to problematise or vindicate conceptual hypocrisy by subsuming it under existing argumentative paradigms. I argue that these attempts fail. In the positive part, I outline an alternative view: some, but not all, instances of hypocrisy are unacceptable. Unacceptable instances of conceptual hypocrisy are not those where a speaker merely does something she says she ought not do; they are those where a speaker does something she says she ought not do, and her doing so indicates that something about her argument has gone wrong.
The efficacy of wastewater treatment plant on removal of perfluoroalkyl substances and their impacts on the coastal environment of False Bay, South Africa
Authors: Ojemaye Cecilia Y. , Abegunde Adeola , Green Lesley , Petrik Leslie
Published: November 2024

Per- and polyfluoroalkyl substances (PFASs), which have their origins in both industrial processes and consumer products, can be detected at all treatment stages in wastewater treatment plants (WWTPs). Quantifying the emissions of PFAS from WWTPs into the marine environment is crucial because of their potential impacts on receiving aquatic ecosystems. In this study, the levels of five PFAS were measured in both influent and effluent sewage water samples obtained from a municipal WWTP, the discharges of which flow into False Bay, on the Indian Ocean coast of Cape Town, South Africa. Additionally, seawater, sediment, and biota samples from eight sites along the False Bay coast were also analysed. Results showed high prevalence of PFAS in the different environmental matrices. Perfluorononanoic acid was most dominant in all these matrices with maximum concentration in wastewater, 10.50 ng/L; seawater, 18.76 ng/L; marine sediment, 239.65 ng/g dry weight (dw); invertebrates, 0.72–2.45 µg/g dw; seaweed, 0.36–2.01 µg/g dw. The study used the chemical fingerprint of five PFASs detected in WWTP effluents to track their dispersion across a large, previously pristine marine environment and examined how each chemical accumulated in different marine organisms. The study also demonstrates that primary and secondary wastewater treatment processes cannot fully remove such compounds. There is thus a need to improve effluent quality before its release into the environment and promote continuous monitoring focusing on the sources of PFAS, including their potential transformation products, their environmental fate and ecological risks, particularly in areas receiving effluents from WWTP.
Physician Documentation of Social Determinants of Health: Results from Two National Surveys
Authors: Iott Bradley E. , Patel Vaishali , Richwine Chelsea
Published: November 2024

Objective

We measured physicians’ (1) perceived importance of having access to social determinants of health (SDOH) data received from external providers in the electronic health record (EHR); (2) internal SDOH documentation practices in the EHR, including whether physicians document SDOH in a structured format that may facilitate use; and (3) use of EHR SDOH data to identify community resources and make referrals on behalf of patients.

Approach

We conducted a secondary analysis of two national physician surveys.

Participants

Respondents from the American Board of Family Medicine Recertification Survey (ABFM, n = 4040), a survey of family physicians fielded 2021–2022, and the National Physician Health IT Survey (NPHIT, n = 3006), a survey of outpatient physicians across specialty areas fielded in 2022.

Key Results

Under half of physicians felt that SDOH data were very important (ABFM: 44.8%, NPHIT: 30.8%). Although most physicians documented SDOH in the EHR (ABFM: 72%, NPHIT: 63.3%), fewer used structured documentation methods (ABFM: 56.3%, NPHIT: 33.2%). In both surveys, physicians who participated in value-based care initiatives, those for whom > 10% of their patient population was considered vulnerable, and those who felt that their clinic had the resources to address patients’ social needs had higher likelihood of documenting SDOH. Sixty-two percent of family physicians reported using SDOH data for identifying resources and making referrals.

Conclusions

In 2022, most physicians documented SDOH data in their EHR, yet fewer used structured methods, limiting data exchange opportunities to address patients’ social needs. Under half of physicians considered access to external SDOH data to be “very” important, suggesting greater reliance on data collected internally and missed opportunities to identify patients who need support. Variation in perceived importance of SDOH data access and SDOH documentation by physician characteristics indicate opportunities to support adoption of structured documentation tools facilitating SDOH data capture and exchange to improve patient-centered care.
Using Risk Assessment to Improve Screening for Albuminuria among US Adults without Diabetes
Authors: Bragg-Gresham Jennifer L. , Annadanam Surekha , Gillespie Brenda , Li Yiting , Powe Neil R. , Saran Rajiv
Published: November 2024

Background

Guidelines currently recommend annual screening for albuminuria only among persons with diabetes mellitus (DM). There is no guidance about albuminuria screening in those with other important risk factors for chronic kidney disease (CKD), such as hypertension and/or family history of kidney disease. We sought to create a risk score that predicts the likelihood of albuminuria in adults without diabetes to prompt earlier detection and management of CKD.

Methods

Data from 44,322 participants without diabetes, aged 18 + years from the National Health and Nutrition Examination Surveys 1999–2020 were analyzed. Survey-weighted logistic regression was used to assess associations between individual characteristics and presence of albuminuria (urinary albumin to creatinine ratio [UACR] ≥ 30 mg/g), including interaction terms, in three separate models. The sample was divided equally into development and validation data sets. C-statistics were used to assess model fit.

Results

The prevalence of albuminuria was 9.7% in the US adult population. Higher odds of albuminuria among the non-diabetic population were observed in females, non-Hispanic Black, and smokers, as well as those with low eGFR, hypertension, cardiovascular disease, prediabetes, low HDL cholesterol, and high uric acid levels. Age showed a J-shaped relationship with albuminuria, with lowest odds for ages 25–64 years. The C-statistic was 0.756 for the developmental and 0.752 for the validation set of the final model. Using this model, screening individuals with a predicted probability of ≥ 5% would capture 85% of individuals with albuminuria.

Conclusions

These results suggest that it may be helpful to use a risk score framework for albuminuria screening in people without DM to encourage earlier detection and management of CKD. Longitudinal studies are warranted to confirm this approach along with evaluation of its cost effectiveness.
Oxynitrided Ti-6Al-4V Coatings Deposited by Twin Wire Arc Spray for Protection of Aluminum Die-Casting Molds
Authors: Nango-Blanco Mauricio , Brizuela-Colmenares Natalia , Pérez Sebastián , Bedoya-Trujillo Iván F. , Benítez-Castro Angélica M. , Cáceres-Díaz Luis A. , Muñoz-Saldaña Juan
Published: November 2024

Steel molds used for aluminum die-casting often fail due to excessive wear or cracking phenomena associated with the soldering effect in contact with molten aluminum, which leads to the formation of iron-based intermetallic compounds and causes problems in the cast components. One solution is to apply protective coatings whose composition is less reactive with the molten aluminum and improve its hardness, toughness, wear, and corrosion resistance, thus prolonging its service life. This work evaluates the effectiveness of Ti-6Al-4V coatings deposited by twin wire arc spraying in an air or nitrogen atmosphere. Nitrogen was used as the carrier and shielding gas for the in-flight molten particles. Coatings were deposited by varying the stand-off distance, the nitrogen gas pressures, and the substrate temperature. The microstructure of the coatings is interlayered, one porous layer of dendrites and one highly densified layer. The presence of TiN, TiO2, α-Ti, and β-Ti phases was confirmed by different characterization methods. For instance, x-ray photoelectron spectroscopy measurements confirmed the presence of N-Ti, O-Ti, and N-O bonds, with the oxygen/nitrogen/titanium percentage associated with the formation of a non-stoichiometric (Ti, Al, V)NxOy phase. Finally, the reactivity of selected oxynitrided Ti-6Al-4V coating in contact with molten aluminum showed a low reaction rate compared to the coarse reaction layer suffered by the uncoated steel substrates.
Improving On-farm Energy Use Efficiency by Optimizing Machinery Operations and Management: A Review
Authors: Jensen Troy A. , Antille Diogenes L. , Tullberg Jeff N.
Published: November 2024

The energy use and emissions from direct fossil fuel combustion on-farms to power farm machinery was critically reviewed. Approximately, 15% of agricultural production costs on-farm are energy-related. A potential solution to more sustainable energy use is a shift toward biofuels from renewable resources. The reduction of greenhouse gas emissions through the substitution of diesel oil with biodiesel depends on the feedstock, the inter-esterification process, the storage period, and ambient conditions. In modern tractors, increased fuel use efficiency (or reduced fuel consumption) has been achieved by power/load matching and the use of variable transmission. Engine management systems that are capable of continuously communicating with the engine and transmission to make appropriate adjustments based on inputs received from the tractor allow for quick and precise responses to changing conditions. As a result, maximum efficiency and productivity can be obtained from the tractor operating similarly to the traditional ‘gear-up and throttle-back’ methods of a proficient operator. The future for autonomous tractors is promising, though not new. Electric-powered tractors are near to commercialization or are already commercially available. Hybrid electric driven tractors present some advantages in terms of increased energy use efficiency and functionalities. Increased efficiency can lead to a reduction in diesel fuel consumption and hence, a concurrent decrease in CO2 emission. Where the local electricity supply has a low-carbon emission factor, this can also result in significant emission reductions. Small light-weight robotic equipment can potentially perform functions currently undertaken by tractor-drawn and other heavy equipment with high-fuel consumption, provided field operating capacity was not compromised. However, the size and weight limitations inherent in current harvesting and transport technology mean that soil compaction will still be a problem with robotic units. The robotic operation of medium-scale equipment within a precision-controlled traffic farming environment should offer more feasible and energy-efficient alternatives.
Evaluation of the Algerian Apricot Phenotypic and Genetic Diversity: Impact of Graft-Propagated Autochthonous and Introduced Cultivars in a Traditional Seed-Propagated System
Authors: Atek Younes , Egea Jose A. , Bahlouli Fayçal , Nicolás-Almansa María , Salazar Juan A. , Martínez-Gómez Pedro
Published: November 2024

Despite the apricot cultivars introduced from Spain and France are displacing the autochthonous Algerian cultivars in each area, there are a lot of local cultivars that still have a great interest and they are cultivated in the orchards from the Algerian arid agrosystem. This study addresses the phenotypical and molecular characterization of autochthonous (Algerian and Tunisian cultivars) and introduced (Spanish and French) graft-propagated apricot cultivars in a traditional seed-propagated system. Sixty-five apricot cultivated autochthonous and introduced accessions from the provinces of Batna (slightly arid area) and M’Sila (semi-arid area) in Algeria have been evaluated. These cultivated accessions included autochthonous Algerian cultivars (graft and seed propagated) selected over the years for its adaptation to warm Mediterranean climate and Spanish and French introduced cultivars (graft propagated). In these materials and agronomical evaluation of phenological (budburst, flowering and ripening date), pomological (fruit weight and yield per tree) and fruit quality (firmness and acidity), traits were performed together with a molecular characterization of the genetic diversity using simple sequence repeat (SSR) marks. Results showed the great diversity at agronomical and molecular level of this Algerian apricot germplasm. The seed-propagated autochthonous cultivars showed a lower yield per tree and fruit weight. Seed-propagated autochthonous also showed a longer fruit development and ripening cycle in comparison with the grafted cultivars with a later ripening date. Regarding fruit quality, seed-propagated autochthonous cultivars present low firmness and high acidity compared with the rest. Results also showed the effectiveness of the SSR markers by the correct identification, detecting some synonymies and suggesting the origin of some autochthonous cultivars. These results will provide more in-depth information to develop a strategy for in situ conservation of cultivars and to reduce gene flow from introduced material to ancient orchards. These materials would be interesting to modify some quality traits such as the acidity or firmness and drought resistance in apricot breeding programs.
A strategy to what end? “The strategy of model building in population biology” in its programmatic context
Authors: Hasnes-Beninson Zvi
Published: November 2024

“The Strategy of Model Building in Population Biology” published by Richard Levins in 1966 has been cited over 2500 times. For a paper concerned with modeling approaches in population biology a surprisingly large part of the attention. The Strategy received comes from history and philosophy of biology, and specifically from accounts on model and model formulation. The Strategy is an unusual paper; it presents neither new data nor a new formal model; at times it reads like a manifesto for some modeling approach, without specifying which broader program that approach intends to support. When these peculiarities of The Strategy are even mentioned, the philosophical literature tends to explain them away by invoking Levins’ Marxist commitments. In contrast, I argue that those peculiarities can be explained by examining the programmatic purpose of the paper; starting from his doctoral work, Levins was trying to establish a research program meant to account for the relations between fitness and environment in different terms than the prevalent lock-and-key view. My paper brings that program back to the discussion, explains its relation to competing approaches and examines Levins’ approach to modeling in light of that context
Putting an Integrated Theoretical Framework of Student Engagement into Practice: A Case Study of Three Student Initiatives at the Technical University of Munich
Authors: Reifenrath Johannes , Buchner Anna , Leeb Antonia , Hermann Lina , Allwang Christine , Dinkel Andreas , Berberat Pascal O. , Wijnen-Meijer Marjo
Published: November 2024

Student engagement is perceived as an increasingly important but complex phenomenon in medical education. Recently, integrated theoretical frameworks have been introduced to conceptualize student engagement from a psychological, behavioral, and psychosocial perspective. The body of literature underpinning the development of the frameworks is enormous, but there is a relative paucity of reports detailing the use of the frameworks in practice. Here, we present a case study of three de novo student initiatives at the Technical University of Munich. The initiatives cover various topics, from case-based learning tutorials to extracurricular offerings on mental health and mentoring. We will map each project to the integrated framework proposed by Kassab et al. (Med Teach 45:949–965, 2023) and assess its usefulness in capturing student engagement. We conclude that the framework holistically describes the engagement profile of each project but does not consider the different roles students assume when participating in a project or incentivizing it.
Road Traffic Injury Prevention: Bicycle
Authors: Hyman Simone Carlson , Ignacio Romeo
Published: November 2024

Purpose of review

We describe recent trends in bicycle-related trauma, associated morbidity and mortality, the disparate effects on adult and pediatric populations, the effects of socioeconomic inequities on injury patterns, and milestones in preventative efforts.

Recent findings

National data demonstrates a lower incidence of unintentional injuries but a higher number of bicycle-related fatalities in the United States over the past decade. Traumatic brain injury remains the leading cause of mortality and chronic morbidity for bicyclists overall. Extremity and facial trauma predominate among older populations, while children are more susceptible to solid organ injuries and severe trauma with the use of electric bicycles. Factors that improve rider safety include changes in infrastructure, speed limits, and the implementation of dedicated bicycle lanes. Helmet usage is the most critical aspect for reducing bicyclist mortality, though rates of consistent usage in the US remain low, they can be improved with mandatory helmet laws. The lowest rates of helmet use are seen in areas of lower socioeconomic status, with these bicyclists subsequently subject to a greater burden of bicycle-related trauma.

Bicycle accidents are relatively common injuries in both adults and children. Road traffic accidents (RTAs), including those involving bicycles and electric bicycles (E-bikes), contributing significantly to morbidity and mortality across age groups. The focus in mitigating these injuries is on preventive measures, emphasizing the role of infrastructure improvements, public policies, and educational initiatives. The review discusses the trends in bicycle-related trauma, disparities affecting different age groups, socioeconomic influences on injury patterns, and recent advancements in injury prevention strategies.
Benchmarking numerical simulation of induced fault slip with semi-analytical solutions
Authors: Novikov Aleksei , Shokrollahzadeh Behbahani Sara , Voskov Denis , Hajibeygi Hadi , Jansen Jan-Dirk
Published: November 2024

Pore pressure fluctuation in subsurface reservoirs and its resulting mechanical response can cause fault reactivation. Numerical simulation of such induced seismicity is important to develop reliable seismic hazard and risk assessments. However, modeling of fault reactivation is quite challenging, especially in the case of displaced faults, i.e., faults with non-zero offset. In this paper, we perform a systematic benchmarking study to validate two recently developed numerical methods for fault slip simulation. Reference solutions are based on a semi-analytical approach that makes use of inclusion theory and Cauchy-type singular integral equations. The two numerical methods both use finite volume discretizations, but they employ different approaches to represent faults. One of them uses a conformal discrete fault model (DFM) while the other employs an embedded (non-conformal) fault model. The semi-analytical test cases cover a vertical frictionless fault, and inclined displaced faults with constant friction and slip-weakening friction. It was found that both numerical methods accurately represent pre-slip stress fields caused by pore pressure changes. Moreover, they also successfully cope with a vertical frictionless fault. However, for the case with an inclined displaced fault with a constant friction coefficient, the embedded method can not converge for the post-slip phase, whereas the DFM successfully coped with both constant and slip-weakening friction coefficients. In its current implementation, the DFM is therefore the model of choice when accurate simulation of local faulted systems is required.
Processing cataphoric they amidst pronominal innovation
Authors: Foley Steven , Ahn Byron
Published: November 2024

When they encounter a cataphoric pronoun during real-time sentence processing, the comprehender begins searching actively for a feature-matched noun that can supply its reference. The present study investigates individual variation in this active search procedure, leveraging an ongoing change in the pronoun system of North American English. The types of referents compatible with the they-series of pronouns is expanding, with an increasing number of speakers allowing definite singular referents: especially but not exclusively when referring to someone with a nonbinary gender identity. Sociolinguistic work shows that the speakers who most accept innovative usages of singular they tend to be younger, or to be non-cisgender (e.g. transgender, nonbinary). Recruiting participants representing diverse ages and gender identities, the present experiment tracked reading times of sentences involving cataphora. Results shows that cataphoric they is processed differently than cataphoric s/he, across the board. There is a significant processing cost to reading a plural noun that follows cataphoric s/he, indicating that singular cataphors evoke strong number expectations. However, the cost of reading a singular noun after they is smaller and emerges later; they seems to evoke weak number expectations. Individual differences show that those expectations are especially weak for younger participants, perhaps reflecting a higher baseline familiarity with singular they. On the other hand, course-grained gender identity (cis vs. non-cis) does not seem to be a reliable predictor of how cataphoric they is processed. Integrating insights from sociolinguistics and psycholinguistics, this study offers a novel view into ongoing language change and its manifestation in real-time processing measures.
Short- and long-term outcomes of adrenalectomy for primary aldosteronism in a single UK center: rear-mirror view
Authors: Abdel-Aziz Tarek , Abdelsalam Alaa , Chung Teng-Teng , Srirangalingam Umasuthan , Hurel Steven , Conway Gerard , Baldeweg Stephanie E. , Kurzawinski Tom R.
Published: November 2024

Purpose

Primary aldosteronism (PA), which is the commonest cause of secondary hypertension, can be cured by unilateral adrenalectomy. We report the short-and long-term outcomes after adrenalectomy performed at a single UK center over a period of 24 years.

Methods

Retrospective analysis of biochemical (potassium, aldosterone, renin, and ARR) radiological (CT/MRI, AVS, and nuclear scans), and clinical (surgical complications, blood pressure, and number of antihypertensive medications) short-and long-terms outcomes in patients who underwent adrenalectomy for PA between 1998 and 2021. Standardized PASO and Clavien-Dindo criteria to assess biochemical, clinical, and surgical outcomes were used.

Results

A total of 82 patients were treated via adrenalectomy for PA over a 24-year period. Short-term follow-up data (within 3 months after surgery) was available for all 82 patients (M45, F37, mean age 51.7 years): 24 of them were followed up for at least 60 months (range 60 to 72 months) and 77 (93.9%) patients had laparoscopic surgery (one conversion). Seven patients had postoperative complications classified as Clavien-Dindo II (4), IIIa(1) and IVa(2). Median LOS was 2.5 days (1–12). Complete and partial clinical success was achieved in 29 and 58.3% and 41.7 and 45.8% of patients in the short and the long term, respectively. Clinical benefit was observed in 88% of patients. Complete biochemical success was achieved in 95.8% of patients in the short and the long term.

Conclusion

Unilateral adrenalectomy in patients with PA showed clinical benefit in 88% and achieved biochemical cure in almost all of them. Our data suggest that these benefits persisted for at least 5 years.
Flotation of a South African Low-Grade Banded Iron Formation (BIF)
Authors: Maistry Nichole , Singh Ashma
Published: November 2024

Due to declining iron ore grades, low-grade ores with complex mineralogy, namely, banded iron formation (BIF), are being explored to maximize iron ore resources and increase the life of mine. Flotation is the standard global process used for the beneficiation of BIF ores, as it is a complex ore reserve, and liberation is typically achieved below 1 mm. This study focuses on flotation of a South African BIF evaluating its response to different collectors, as well as effect of grind. Since flotation is an expensive process and South Africa ranks high on the production cost curve, pre-concentration via gravity or magnetic separation is performed prior to flotation. Thus, flotation was also performed on a gravity concentrate to determine if a grade suitable for steelmaking (~ 63%) is achievable. The results indicate that the use of an alkyl ether amine-based collector partially neutralized with acetic acid is suitable for separation of hematite from illite and quartz at high pH values. Further optimization tests are being pursued to improve overall recovery and grade.
Physiological and Molecular Responses of Red Amaranth (Amaranthus cruentus L.) and Green Amaranth (Amaranthus hypochondriacus L.) to Salt Stress
Authors: Emam Tartil M. , Hosni Abd Elaziz M. , Ismail Ahmed , El-Kinany Ramy G. , Hewidy Mohammed , Saudy Hani Saber , Omar Mohamed M. A. , Ibrahim Mariam T. S. , Sui Shunzhao , El-Sayed Salwa M.
Published: November 2024

Salinization, as a serious climate change phenomenon, continues to cause critical issues for soils and crops. Abundance of genetic diversity of plants could contribute in solving the impacts of salinity. However, the relations between physiological and molecular traits of plant species need deep investigation and interpretation. Pot experiments were conducted in the greenhouse to investigate the difference in behavior between two amaranth species when they were beforehand subjected to salinity-stress conditions, specifically on some specific physiological and molecular characteristics. After 45 days from transplanting, salt stress was induced using a 150 mM sodium chloride solution. Treatments were arranged in randomized complete block design using three replications. After 0, 2, 6, 10, and 24 h, samples were collected to evaluate physiological data as well as diversity of gene expression. The samples were immediately frozen in liquid nitrogen and stored in -80⁰ C ultralow temperature refrigerators. Findings revealed that the red amaranth species (Amaranthus cruentus) was more tolerant to saline stress than the green amaranth species (Amaranthus hypochondriacus). Result data revealed that malondialdehyde (MDA) content in the red amaranth increased after 2 h then decreased (after 6 and 10 h) before rising again after 24 h. In the green amaranth, MDA content initially decreased after 2 h before increasing and later decreasing in a zigzag pattern ending in an increase after 24 h. There was an initial steep rise in proline content of green amaranth after 2 h which continued to still rise moderately till 24 h. In the red amaranth the initial rise in proline continued after 2, 6 and 10 h before it stopped. Results also showed that red amaranth gave higher value of superoxide dismutase (SOD) activity as compared with green amaranth in all tested salinity exposure times. The investigation on the expression of four genes assessed through quantitative PCR indicated the efficiency of red amaranth in increasing the expression of SOS1, HKT1, NHX1, and DGR2 genes, which encode adaptation-related proteins under salinity stress. In summary, the current work demonstrated that red amaranth could be an efficient genetic resource in improving salt-tolerant genotypes belonging to Amaranthus genus.