bluuebunny/crossref_metadata_2025 huggingface dataset:
Issue ownership of science in the United States
Authors: Hardy Bruce W. , Tallapragada Meghnaa , Baik Elizabeth Sungsoo , Koshy Abraham
Published: February 2024

This study assesses whether the Democratic Party holds issue ownership over science in the United States. We analyze data from a national survey that asked 1041 adults questions specifically designed to measure perceptions of science ownership. While the results suggest that the Democratic Party does hold a significant advantage in ownership of science in an abstract sense, perceptions of ownership of specific types of science vary across the two parties. Those who identify as Independents drive much of the aggregate perceptions of ownership of science, whereas partisans’ perceptions of issue ownership of science are mostly driven by in-party favoritism. Post hoc analyses suggest that news media use contributes to perceptions of science ownership and reinforces affinity-party preference.
Changes in the Proportion of Each Cell Type After hiPSC-Derived Airway Epithelia Transplantation
Authors: Kitano Masayuki , Hayashi Yasuyuki , Ohnishi Hiroe , Okuyama Hideaki , Yoshimatsu Masayoshi , Mizuno Keisuke , Kuwata Fumihiko , Tada Takeshi , Kishimoto Yo , Morita Satoshi , Omori Koichi
Published: February 2024

No radical treatment is available for the regeneration of dysfunction and defects in airway epithelia. Artificial tracheae made of polypropylene and collagen sponge were used in clinical studies to reconstitute tracheae after resection. For early epithelialization of the luminal surface of the artificial trachea, a model was established, that is, an artificial trachea covered with human-induced pluripotent stem cell-derived airway epithelial cells (hiPSC-AECs) was transplanted into a tracheal defect in an immunodeficient rat. Unlike the cell types of hiPSC-derived cells that are currently used in clinical studies, AECs maintain tissues by proliferation and differentiation of basal cells into various cell types that constitute AECs constantly. Therefore, post-transplantation, the proportion of each cell type, such as ciliated and goblet cells, may change; however, no studies have examined this possibility. In this study, using our hiPSC-AEC-transplanted rat model, we investigated changes in the proportion of each cell type in hiPSC-AECs pre-transplantation and post-transplantation. As a result, the proportion of each cell type changed post-transplantation. The proportion of ciliated, basal, and club cells increased, and the proportion of goblet cells decreased post-transplantation. In addition, the proportion of each cell type in engrafted hiPSC-AECs is more similar to the proportion of each cell type in normal proximal airway tissue than the proportion of each cell type pre-transplantation. The results of this study are useful for the development of therapeutic techniques using hiPSC-AEC transplantation.
Maternal Parenting Styles and Middle Childhood Temperament Patterns: A Comparison Between Two Social Classes Residing in an Urban Community
Authors: Kota Raga Sumedha , Prasad Hrishikesh Giri , Reddy Ramsubba
Published: February 2024

Background:

Parenting refers to the usual approaches that parents use in child rearing and is one of the many aspects that play a role in the development of both adaptive and maladaptive behavior in children and adolescents. Parenting styles may be authoritarian, authoritative, or permissive. Temperament refers to the stylistic aspect of behavior and individual differences in behavioral characteristics. This study aimed to compare maternal parenting styles and childhood temperamental patterns between two socioeconomic classes.

Methods:

This was a cross-sectional study. Sixty mothers from middle and lower socioeconomic status residing in an urban community in Hyderabad were chosen for the study. Data was collected from January to February 2020. Every participant was a mother of two children in the age group 6–12 years. A semi-structured intake proforma was used, along with the Temperament Measurement Schedule and Parental Styles Questionnaire. Factorial ANOVA was used to explore the differences among the different groups.

Results:

In 76% of the participants, the predominant parenting style was found to be authoritative. Statistically significant differences in parenting styles were seen between the middle and low socioeconomic status groups. Parenting styles differed with the gender of the child. The education of the mother influenced the parenting style. Illiterate participants and participants who did not have at least tenth-grade education had an authoritarian parenting style. Second-born children scored high on the sociability factor compared to firstborn children. The difference between first- and second-born children was statistically significant. Socioeconomic status and the gender of the child had a statistically significant association.

Conclusions:

Parenting is a complex phenomenon that is influenced by many factors, social class being one such factor.
The association between type 2 diabetes mellitus/prediabetes status and femoral neck bone mineral density in old adults
Authors: Wang Bo , Shi Chenhao , Zhu Zhongxin
Published: February 2024

Background

The prevalence of both type 2 diabetes mellitus (T2DM) and osteoporosis has been increasing among older individuals, with these two health conditions often coexisting. Our aim in this study was to evaluate the association between T2DM status and bone mineral density (BMD) of the femoral neck among older adults in the United States.

Methods

This was a retrospective analysis of the data from 5695 adults, 60–80 years of age. The data were obtained from the National Health and Nutrition Examination Survey, for the following years: 2005–2006, 2007–2008, 2009–2010, 2013–2014, and 2017–2018. Weighted multivariable regression analyses, with subgroup analyses as appropriate, were performed to identify an association between T2DM/prediabetes status and femoral BMD and mediating factors.

Results

There was a significant positive association between T2DM/prediabetes status and femoral neck BMD among older women, but not men, after adjusting for body mass index (BMI). On subgroup analysis, stratified by BMI, the significant positive association was retained for T2DM women with a BMI of 25–29.9 kg/m2 (β, 0.030; 95% CI, 0.007–0.052) or ≥30 kg/m2 (β, 0.029; 95% CI, 0.007–0.05), and for prediabetes women with a BMI of 25–29.9 kg/m2 (β, 0.016; 95% CI, 0.001–0.030).

Conclusions

The association between a positive T2DM/prediabetes status and femoral neck BMD differed by sex among older individuals, with the association being further modulated by BMI. For women with a BMI of 25–29.9 kg/m2 or ≥30 kg/m2, T2DM was associated with a significantly higher femoral neck BMD, compared to the non-diabetes group.
Multiple Dimensions of Machismo: Linguistic Considerations for Latino Sexual Minority Men in the United States
Authors: Robles Gabriel , Dellucci Trey V. , Garcia-Perez Javier , Starks Tyrel J.
Published: February 2024

The literature differentiates between two domains of machismo: traditional machismo and caballerismo. Research has largely focused on measuring machismo among English speakers. We evaluated whether Estrada’s (2011) 2-factor model of machismo was invariant across language (English vs. a direct Spanish translation). A series of multigroup confirmatory factor analyses were conducted between respondents who completed the survey in English ( n = 428) and Spanish ( n = 102). Analyses suggested the hypothesized 2-factor model did not fit across language groups. While the traditional 2-factor structure emerged in the English language data, exploratory factor analysis indicated a 3-factor structure of machismo among Spanish-speaking respondents. One of the new factors (inherent machismo), among Spanish-speaking respondents, was associated with internalized heterosexism, suggesting that the new factor structure may capture the belief that masculine men are superior. These findings suggest there is a need for the development of culturally appropriate Spanish language assessment.
Revolutionary Confucianism? Neo-Confucian Idealism and Modern Chinese Revolutionary Thought
Authors: Hoston Germaine A.
Published: February 2024

This article explores the relationship between materialism and philosophical idealism in the political philosophy of Marxist revolutionary movements, by illuminating the influence of Neo-Confucian idealism on the sinification of Marxism. Although they had virtually no access to the writings of the young Marx, Li Dazhao and Mao Zedong incorporated idealist philosophical ideas into their sinified Marxism. I argue that three elements of Neo-Confucian idealism contributed to the sinification of Marxism that emerged by the 1940s: (1) acknowledgment of the real existence of the material world as apprehended by the mind-and-heart in Zhu Xi’s Neo-Confucianism; (2) emphasis on human will and consciousness, drawn from Wang Yangming’s Neo-Confucianism; and (3) recognition of an autonomous, even decisive role of consciousness and culture in revolutionary change. The resulting sinified Marxism constituted a revolutionary New Confucianism, highlighting the most universal, humanistic, liberative elements in the Chinese philosophical tradition. These community-affirming and spiritually rich elements can be mobilized against authoritarian forces to support the continuing struggle for human rights and democratization within and well beyond China today.
Exploring the Threat of Fake News: Facts, Opinions, and Judgement
Authors: Baron Ilan Zvi , Ish-Shalom Piki
Published: February 2024

This article explores how fake news, variously described as misinformation, disinformation, malinformation, and post-truth threatens our pluralistic democratic life. We ask, how does fake news function in constructing a world of meaning that destabilises the conditions under which we are able to render valid political judgements in democratic life? Using the 1992 R v Zundel Supreme Court Case from Canada to explore the free speech question, and Hannah Arendt’s distinction between fact and opinion, we argue that fake news uses the malleability of language to displace fact with opinion. This displacement threatens democracy in two ways. First, fake news functions by deploying language in such a way that it is built on refuting its own ability to produce factual knowledge, and in the process the world becomes one of opinion treated axiomatically. Second, as a consequence, it renders judgement impossible because the only information that counts is opinion, whereas judgement corresponds to the public character of factual knowledge. This displacement produces a pseudo-reality where we can imagine that only people like us live here, that is, people who share our own opinions. This is a world that Hannah Arendt and Hans Jonas might characterise as thoughtless.
Effectiveness of HMG-CoA reductase inhibitors on inflammation and metabolic markers in the US-Mexico border Hispanic population
Authors: Nguyen Phong , Singh Vishwajeet , Thakur Vikram , Dwivedi Alok Kumar , Chattopadhyay Munmun
Published: February 2024

HMG-CoA reductase inhibitors (statins) are commonly used to manage dyslipidemia to reduce cardiovascular disease (CVD) risk. High-sensitivity C-reactive protein (hs-CRP) is an emerging systematic low-grade inflammatory marker associated with atherosclerotic CVD development. Despite racial/ethnic disparities in the use and response of statins and the anti-inflammatory effects of statins, the effectiveness of statins on inflammation and metabolic markers is unknown among Hispanics. We performed a retrospective cohort study using 150 adult patients scheduled for an annual physical examination at a family medicine clinic between January 1, 2021 and December 31, 2021. Effect size with a 95% confidence interval (CI) was estimated using adjusted regression analyses. Among 150 patients, 52 (34.7%) patients received statins. Patients who received statins had significantly reduced median hs-CRP (1.9 vs 3.2, p = 0.007), mean low-density lipoprotein (LDL-C; 101.2 vs 124.6, p < 0.001), and total cholesterol (172.6 vs 194.5, p < 0.001) concentrations compared to those who did not receive statins. In the propensity-scores matched analysis, lower concentrations of log-transformed hs-CRP (regression coefficient (RC), −0.48; 95% CI: −0.89, −0.07), LDL-C (RC, −19.57; 95% CI: −33.04, −6.10), and total cholesterol (RC, −23.47; 95% CI: −38.96, −7.98) were associated with statin use. In addition, hepatic steatosis (adjusted relative risk (aRR) = 0.25; 95% CI: 0.08, 0.78, p = 0.017) was significantly lower among patients with the use of statins. Our study suggests that HMG-CoA reductase inhibitors may help reduce inflammation among Hispanic patients with dyslipidemia and hypertension. These findings have useful implications for preventing risk and disparities associated with cardiovascular and other inflammatory-induced diseases among the fastest-growing US Hispanic minorities.
Responding to a Wicked Problem: How Time, Sense of Place, and Organisational Boundaries Shape Companies’ Decarbonisation Strategies
Authors: Canal Vieira Leticia , Longo Mariolina , Mura Matteo
Published: February 2024

A rapidly expanding number of companies have pledged to contribute towards the Paris Agreement’s goal by establishing 2050 net-zero emissions targets. However, the literature lacks an in-depth analysis of firms’ strategies to reach those targets and their underlying assumptions. Scholars increasingly use time and space as functional constructs to theorise what motivates different business responses to climate change. Organisational boundaries represent an additional critical dimension when analysing companies’ climate actions. Hence, we adopted a novel tri-dimensional framework (time, sense of place, and organisational boundaries) to analyse the link between the targets companies set and their proposed decarbonisation strategies. We conducted a qualitative content analysis of self-reported and tertiary data from 45 European manufacturing companies rated as leaders in climate action. By investigating how time, sense of place, and organisational boundaries substantiate companies’ decarbonisation strategies’ present and possible future impact, we delineate how different approaches to the three dimensions enable or constrain the comprehensives of net-zero strategies.
Assessing Adult ADHD: An Updated Review of Rating Scales for Adult Attention Deficit Hyperactivity Disorder (ADHD)
Authors: Caroline S. Sharon Suganthi , Sudhir Paulomi M. , Mehta Urvakhsh Meherwan , Kandasamy Arun , Thennarasu K , Benegal Vivek
Published: February 2024

Adult ADHD is a prevalent yet underdiagnosed and undertreated condition. Assessment of ADHD is critical to understanding and managing ADHD comprehensively.

Method:

Scholarly articles on adult ADHD between 1996 and 2022 were reviewed using the PRISMA guidelines. ADHD rating scales with multiple citations were selected and their psychometric properties and symptom coverage were analyzed.

Results:

Ten rating scales, with sound psychometric properties, were identified. Out of those reviewed two (BADDS and BAARS-IV) load on the inattentive domain of ADHD, while the rest focus on a comprehensive assessment of ADHD. Only one scale (BARRS-IV) incorporates an assessment of functional impairment. Some scales though widely utilized have not been adequately examined for their sensitivity.

Conclusions:

Rating scales are reliable and valid, in the assessment of adult ADHD. We present a review of recent scales, with an expanded focus, to help clinicians make informed decisions on diagnosis, identifying targets and planning interventions accordingly.
Trends in prevalence and complications for smokers who underwent total hip arthroplasty from 2011 to 2019: an analysis of 243,163 patients
Authors: Hadad Matthew J , Grits Daniel , Emara Ahmed K , Orr Melissa N , Murray Trevor G , Piuzzi Nicolas Santiago
Published: February 2024

Background:

Smoking is an established risk factor for postoperative complications after total hip arthroplasty (THA). It is unknown if the decreasing prevalence of adult smoking in the United States is reflected in the elective THA patient population. We aimed to investigate recent trends in: (1) the prevalence of smoking pre-THA, stratified by patient demographics; and (2) rates of 30-day complications and increased healthcare utilisation post-THA in smokers versus non-smokers.

Methods:

Patients who underwent primary elective THA (2011–2019) were identified using the National Surgical Quality Improvement Program database. A total of 243,163 cases (Smokers: n = 30,536; Non-smokers: n = 212,627) were included. Trends analyses were performed for smoking prevalence across the study period. Smokers were propensity score-matched (1:1) to a cohort of non-smokers ( n = 29,628, each), and rates of 30-day complications, readmission, and non-home discharge were compared.

Results:

The rate of preoperative smoking significantly decreased from 14.0% in 2011 to 11.6% in 2019 ( p-trend = 0.0286). When stratified, a significant decreasing trend in smoking was found for males and all races; within races, American-Indian/Alaska-Native race had the sharpest decline (2011:36.3% vs. 2019:23.2%). No significant change in 30-day complication rates among smokers or non-smokers was observed ( p-trend > 0.05), but non-home discharge significantly decreased for both smokers ( p-trend = 0.001) and non-smokers ( p-trend < 0.001). After matching, higher rates of superficial surgical site infections (SSI) (0.9% vs. 0.5%; p < 0.001), deep SSI (0.5% vs. 0.3%; p < 0.001), wound disruption (0.2% vs. 0.1%; p = 0.006), and readmission (4.2% vs. 3.1%; p = <0.001) were found in smokers versus non-smokers.

Conclusions:

The present study is encouraging that national efforts to reduce the prevalence of smoking may be successful within the THA population, but there is a persistently elevated risk of postoperative complications in smokers after THA.
Nurse-focused ultrasound-guided IV program improves core emergency department process measures
Authors: Kessler Ross , Hall Jane , Chipman Anne K , Hall Michael Kennedy , Amick Ashley
Published: February 2024

Introduction:

Ultrasound-guided peripheral IV catheter (USGIV) insertion is as an effective procedure to establish access in patients with difficult intravenous access (DIVA), a condition frequently encountered in the Emergency Department (ED). This study describes a DIVA quality improvement program focusing on rapid identification of DIVA patients and emergency nurse USGIV training and evaluates its impact on overall frequency of USGIV use and process measures related to quality of patient care.

Methods:

This is a retrospective cohort study of patients over 18 years of age, presenting to a single, tertiary care hospital between September 1, 2018 and September 30, 2020. Difference-in-difference analysis was used to compare ED process measures pre- and post-implementation of the DIVA Program, and multivariate logistic regression was used to identify associations between patient characteristics and difficult IV access.

Results:

The frequency of ED encounters associated with USGIV placement more than doubled post-implementation of the DIVA Program, rising from 606 to 1323. There were improved covariate-adjusted time estimates of core ED process measures for encounters associated with USGIV placement post-implementation, including decreases in time to CT with contrast from 4.8 h (95% CI = 4.4–5.2) to 4.1 h (95% CI = 3.8–4.4), pain medications from 2.4 h (95% CI = 2.1–2.6) to 1.8 h (95% CI = 1.6–2.0), IV antibiotics from 3.0 h (95% CI = 2.4–3.7) to 2.1 h (95% CI = 1.5–2.6), and ED length of stay from 6.4 h (95% CI = 6.2–6.6) to 6.0 h (95% CI = 5.9–6.2).

Conclusion:

A nurse-focused quality improvement program focused on teaching and promoting USGIV as a modality for managing difficult IV access was associated with increases in USGIV placement and improvements in core process measures related to quality of patient care.
Clinicopathological Features and Treatment Outcomes of Male Breast Cancer in Pakistani Population: A 10-Year Retrospective Cross-Sectional Study
Authors: Khalid Ibtissam Bin , Sarwar Albash , Khalid Hassham Bin , Sajjad Barka , Rehman Bushra , Parvaiz Muhammad Asad
Published: February 2024

Background:

Male breast cancer (MBC) accounts for 1% of global breast cancer cases. On account of its rarity, very few prospective clinical trials have been carried out on MBC. Pakistan has the highest incidence of breast cancer in Asia, but very limited data are available on MBC.

Objectives:

The objective is to determine the clinicopathological characteristics and treatment patterns of MBC in Pakistani population.

Design:

This is a retrospective cross-sectional study.

Methods:

A retrospective cross-sectional study carried out using the cancer database of Shaukat Khanum Memorial Cancer Hospital & Research Center. Men with a histologically proven breast cancer, stage 0 to III disease and requiring surgical intervention were included. The Kaplan-Meier curve and log-rank test were used for survival analysis.

Results:

Sixty-eight patients with MBC were included with a median age at diagnosis of 55 years. Most patients were stage II (47.1%). Invasive ductal carcinoma (IDC) was the commonest type (89.7%). Estrogen receptor (ER), progesterone receptor (PR), and Her-2 receptor positivity were 92.6%, 86.8%, and 32.4%, respectively. Mastectomy was performed in 95.6% of the cases. Neoadjuvant and adjuvant chemotherapy was administered in 25 (36.8%) and 26 (38.2%) patients, respectively. Fifty-five (80.9%) patients received adjuvant radiotherapy. Most of the patients (89.7%) received tamoxifen. The 5-year overall and disease-free survival was 88.2% and 80.9%, respectively. Patients receiving neoadjuvant chemotherapy had a better overall and disease-free survival ( P = .025).

Conclusions:

Male breast cancer occurs at a relatively earlier age in Pakistani population as compared with Western men. Mastectomy is the preferred surgical option for MBC on account of the advanced disease and delayed presentation. Neoadjuvant chemotherapy has a statistically significant effect on overall and disease-free survival, but in spite of these benefits, it remains underutilized.
Domestic service and prostitution: Empirical and theoretical connections
Authors: Orian Weiss Catherine
Published: February 2024

Various activities are systematically imposed on women in both paid and unpaid forms, generally involving care for others, sexual activity, or a combination of both. These activities have typically been studied separately, but these analytical divisions are increasingly being questioned. This article contributes to this debate by exploring empirical and theoretical connections two of the most prominent of these activities, prostitution and domestic service. Through a survey of the empirical literature on migration for domestic service, the article identifies four themes that suggest why some migrant women move between domestic service and prostitution: pre-existing structural constraints, migration conditions, working conditions, and migration policies. Subsequently, drawing on the work of French materialist feminists Colette Guillaumin and Paola Tabet and political theorist Carole Pateman, it sketches the outline of a theoretical account of the relationship between these two activities.
Prediction of transmission routes of respiratory infectious diseases in indoor environment: Based on droplet evaporation and sedimentation analysis
Authors: Guo Luyao , Cheng Zhu , Jiang Xingchi , Long Enshen
Published: February 2024

Many respiratory infectious diseases are believed to be transmitted from person to person through droplet nuclei in the air or contact with droplet-contaminated surfaces. Most studies related to droplet evaporation only focus on the evaporation process, without dividing the transmission routes of diseases caused by droplet evaporation. In this paper, the actual size of droplet nuclei was analyzed, and droplet evaporation and the changes in component content were predicted. Especially considering the dynamic effect of evaporation on droplets size change, a more realistic sedimentation model was established, and the probability of pathogen transmission through different routes and the corresponding droplet size distribution range were analyzed. The results showed that the size of droplet nuclei and the rate of the evaporation process together determined the time required for droplet evaporation. The number of droplets still suspended in the air after the end of evaporation is much higher than the number of droplets settling on the ground. In addition, the differences in component content during the evaporation process may affect the inactivation of pathogens in droplets. This study provided a reference for the prevention and control strategies of respiratory infectious diseases in indoor environments.
Short- and long-term outcome after colon cancer resections performed by male and female surgeons: A single-center retrospective cohort study
Authors: Engdahl Jenny , Öberg Astrid , Bech-Larsen Sandra , Bergenfeldt Henrik , Vedin Tomas , Edelhamre Marcus , Öberg Stefan
Published: February 2024

Background and objective:

To assess the effect of surgeon sex on short- and long-term outcomes after colon cancer resections.

Methods:

Clinical data of patients who underwent colon cancer resections between 2010 and 2020 at Helsingborg Hospital, Sweden, were retrospectively obtained from medical records. The sex of the surgeon of each procedure was recorded. Morbidity, mortality, and long-term survival were compared in patients operated by male and female surgeons.

Results:

Colon cancer resections were performed by 23 male and 9 female surgeons in 1113 patients (79% elective, 21% emergent). After elective surgery, there was no difference in postoperative complications, 30-day mortality, or long-term survival between patients operated by male and female surgeons. Following emergent resections, the complication rate was significantly lower in patients operated by female surgeons (41.3% vs 58.1%, p = 0.019). Similarly, the rates of R1-resections (0% vs 5.2%, p = 0.039), reoperations (3.8% vs 14.2%, p = 0.014), and intensive care unit (ICU) care (6.3% vs 17.4%, p = 0.018) were significantly lower for patients operated by female surgeons, but there was no difference in 30-day mortality (6.3% vs 5.2%, p = 0.767). Cox regression analysis showed that long-term and cancer-free survival in patients emergently operated by male surgeons was significantly shorter than that of patients operated by female surgeons (hazard ratio = 1.9 (95% confidence interval (CI) = 1.3–2.8), p = 0.001 and hazard ratio = 1.7 (95% CI = 1.1–2.7), p = 0.016).

Conclusions:

The short- and long-term outcome after elective colon cancer resections were similar in patients operated by male and female surgeons. The outcome following emergent resections performed by female surgeons compared favorably with that of male surgeons, with fewer complications and reoperations and better long-term survival.
The architecture of visual narrative: Can text-to-image algorithms enhance the power of stylistic narrative for architecture
Authors: Dilaveroglu Busra
Published: February 2024

Architecture has always been a means of communicating stories through its design, with its structures and spaces serving as visual narratives. However, recent advancements in technology have created opportunities for architects to enhance their storytelling capabilities through the use of text-to-image algorithms. These algorithms have the potential to improve visual narratives by enabling architects to translate written descriptions into tangible visual representations. This article explores the architecture of visual narrative and how text-to-image algorithms can enhance it in diverse styles. This inquiry aims to help architectural epistemology understand and foresee the potential impact of this technology on the field of architecture. To understand the limits of AI in generating styles to enhance architectural narrative, six distinct styles were chosen for experimentation. The styles were selected based on their unique features, including an architect’s style, movement, or era. These styles include Zaha Hadid, Brutalist, modern-minimalistic, Peter Zumthor, Gothic, and Gaudi. The narrative was kept the same for each style while observing the changes in AI-generated visuals. The results were evaluated by comparing AI’s interpretations in terms of stylistic, environmental, material, form-based, and atmospheric features. While the results showed promise in terms of variations in each category, AI was not successful in implementing all stylistic features while keeping the narrative stable. In particular, after the second environment layer, the modern-minimalistic, Zumthor, and Brutalist styles lost their distinct features, while Gothic and Gaudi-inspired visuals were hardly generated even in the second environment layer. As a result, AI performed well in generating detailed environmental features without any given narrative and creating an atmospheric environment with enlightening the environment for the last layer.
A Systematic Review on Thoracic Endovascular Repair Outcomes in Blunt Thoracic Aortic Injuries
Authors: Nana Petroula , Spanos Konstantinos , Behrendt Christian-Alexander , Brodis Alexandros , Haulon Stéphan , Kölbel Tilo
Published: February 2024

Purpose:

Blunt thoracic aortic injury (BTAI) represents a potentially life-threatening condition and thoracic endovascular aortic repair (TEVAR) is recommended as the first-line treatment (Class I level of evidence C) by the current guidelines. The aim of this systematic review was to determine the perioperative and mid-term follow-up outcomes of patients with BTAI treated with TEVAR.

Materials and Methods:

We reviewed the English literature published between 2000 and 2022, via Ovid, using MEDLINE, EMBASE, and CENTRAL databases, until July 30, 2022. Observational studies and case series, with ≥5 patients, reporting on the perioperative and follow-up outcomes of patients who underwent TEVAR for BTAI were included. The Newcastle-Ottawa Scale was used to assess the risk of bias. Primary outcomes were technical success and 30-day mortality, cerebrovascular morbidity. Secondary outcomes were mortality and re-interventions during the mid-term follow-up.

Results:

From 5201 articles identified by the literature search, 35 eligible studies were included in this review. All studies had a retrospective study design. In total, 991 patients were included. The mean age was 34.5±16.5 years (range=16–89 years). Technical success was 98.0% (odds ratio [OR], 95% confidence interval [CI]=0.98, 0.99, p<0.001, I2=0%). Mortality at 30 days was 5.0% (OR, 95% CI=0.03, 0.06, p<0.001, I2=5.56%). Spinal cord ischemia occurred in 1.0% (OR, 95% CI=0.01, 0.02, p<0.001, I2=0%) and stroke rate was 2.0% (OR, 95% CI=0.01, 0.02, p<0.001, I2=0%). The available follow-up was estimated at 29 months (range=3–119 months) with mortality rate at 2.0% (OR, 95% CI=0.01, 0.02, p<0.001, I2=0%) and re-intervention rate at 1.0% (OR, 95% CI=0.01, 0.02, p<0.001, I2=10.5%).

Conclusion:

Thoracic endovascular aortic repair showed high technical success and low early cerebrovascular morbidity and mortality rates. In the mid-term follow-up, the estimated mortality and re-intervention rates were also low. Furthermore, higher quality prospective studies are needed.

Clinical Impact

Thoracic endovascular aortic repair (TEVAR) is recommended as the first line treatement in patients with blunt thoracic aortic injuries (BTAI). This systematic review of 35 retrospective studies and 991 patients showed high technical success (98.0%) with an associated 30-day mortality at 5.0% and low spinal cord ischemia (1%) and stroke rates (2.0%). Mid-term mortality and re-intervention rates reassure the effectiveness of TEVAR in BTAI cases.
Rethinking the clinical research protocol: Lessons learned from the COVID-19 pandemic and recommendations for reducing noncompliance
Authors: Gooden Matthew J , Norato Gina , Landry Katherine , Martin Sandra B , Nath Avindra , Reoma Lauren
Published: February 2024

Background/Aims

Since the onset of the coronavirus disease 2019 (COVID-19) pandemic, 103.4 million cases and 1.1 million deaths have occurred nationally as of November 2023. Despite the benefit of mitigating measures, the pandemic’s effect on participant safety is rarely documented.

Methods

This study assessed noncompliance occurring from July 2019 to August 2021 that were stratified by the date of noncompliance (before or after restrictions). Events were described by size, site, noncompliance type, primary category, subcategory, and cause. In addition, noncompliance associated with COVID-19 was analyzed to determine characteristics.

Results

In total, 323 noncompliance events occurred across 21,146 participants at risk in 35 protocols. The overall rate of noncompliance increased from 0.008 events per participant to 0.022 events per participant after the COVID-19 restrictions ( p < 0.001). For onsite protocols, the median within protocol change in rates was 0.001 (interquartile range = 0.141) after the onset of COVID-19 restrictions ( p = 0.54). For large-sized protocols ( n ≥ 100), the median within protocol change in rates was also 0.001 (interquartile range = 0.017) after COVID-19 restrictions ( p = 0.15). For events related to COVID-19 restrictions, 160/162 (99%) were minor deviations, 161/162 (99%) were procedural noncompliance, and 124/162 (77%) were an incomplete study visit.

Conclusion

These noncompliance events have implications for clinical trial methodology because nonadherence to trial design can lead to participant safety concerns and loss of trial data validity. Protocols should be written to better facilitate the capture of all safety and efficacy data. This recommendation should be considered when changes occur to the protocol environment that are outside of the study team’s control.
Lived experiences of study programme leadership in Norwegian higher education
Authors: Haugen Kristin , Tosterud Randi Beate , Wangensteen Sigrid , Hoveid Marit Honerød
Published: February 2024

This qualitative study explores the lived experiences of study programme leadership in development processes in higher education (HE). Study programme leaders are considered crucial in enhancing high-quality study programmes. Using a phenomenological hermeneutic approach, we analysed data from 18 interviews representing study programme leaders from six distinct health profession bachelor programmes at two Norwegian multi-campus institutions. Our findings paint a metaphorical picture of study programme leadership, likening it to leading as in alternating currents where signals flow and change direction. These leaders adeptly navigate an ever-evolving educational landscape filled with horizontal and vertical signals, tensions, and expectations. However, some express a lack of motivation and preparation to enter this field of tension. Our analysis identifies three aspects of study programme leadership: transforming, bridging, and balancing. Through their leadership, study programme leaders serve as vital antennas in development processes, capturing signals, coordinating activities, and fostering connections. Furthermore, they are a pivotal nexus through their transformative and bridging efforts. Balancing various leadership approaches enables them to navigate the changing currents. This study's implications are relevant to the HE field, offering valuable insights into study programme leadership. By emphasising the pivotal role of study programme leaders, it contributes to advancing HE development processes, underscoring the need for heightened awareness and further development of these leadership roles.
Targeted muscle reinnervation in bionic upper limb reconstruction: current status and future directions
Authors: Gstoettner Clemens , Laengle Gregor , Harnoncourt Leopold , Sassu Paolo , Aszmann Oskar C.
Published: February 2024

Selective nerve transfers are used in the setting of upper limb amputation to improve myoelectric prosthesis control. This surgical concept is referred to as targeted muscle reinnervation (TMR) and describes the rerouting of the major nerves of the arm onto the motor branches of the residual limb musculature. Aside from providing additional myosignals for prosthetic control, TMR can treat and prevent neuroma pain and possibly also phantom limb pain. This article reviews the history and current applications of TMR in upper limb amputation, with a focus on practical considerations. It further explores and identifies technological innovations to improve the man–machine interface in amputation care, particularly regarding implantable interfaces, such as muscle electrodes and osseointegration. Finally, future clinical directions and possible scientific avenues in this field are presented and critically discussed.
A real-world study of quality of life following treatment with xylometazoline hydrochloride in individuals with common cold
Authors: Hagen Martina , Clark Kim , Kalita Pranab , Serra Gessica , Sanchez Edwin , Varbiro Gabor , Albasser Mathieu M.
Published: February 2024

Background:

The common cold is a frequent, acute, and mild upper respiratory human disease. Nasal congestion has been considered the most bothersome symptom in the common cold, impacting quality of life (QoL). Topical decongestants containing steroids benefit QoL in allergic rhinitis, but no published research has assessed the impact of topical decongestants on QoL in the common cold.

Objective:

To evaluate the effects of xylometazoline hydrochloride 0.1% (Otrivin, GSK Consumer Healthcare SARL, Switzerland) for up to 7 days on QoL in participants with nasal congestion associated with the common cold.

Design:

This was a decentralized, longitudinal, open-label study.

Methods:

The study enrolled 136 participants (⩾18 years) with early symptoms of the common cold, of which 102 were included in the modified intention-to-treat (mITT) population. Within 24 h of study product receipt, participants confirmed a ‘plugged nose’ and ⩾1 other common cold symptom. Primary endpoints were Wisconsin Upper Respiratory Symptom Survey-21 (WURSS-21) total score, total and individual symptom scores, and total QoL score. Secondary endpoints were additional QoL scores. Exploratory and post hoc analyses included median days to resolution for each QoL factor and analyses of five QoL categories.

Results:

Consistent improvements in symptoms and QoL were seen in the mITT population. From day 1, improvements were seen in the ‘plugged nose’ symptom ( p = 0.0023), WURSS-21 total QoL score, and all individual QoL scores ( p < 0.0001 for all). After the last dose needed, significant improvements were seen in sleep quality (73%), vitality (76%), physical activity (71%), social activity (80%), and sensation (81%). No serious or unexpected adverse events were reported.

Conclusion:

This study is the first to demonstrate in a real-life setting that treating nasal congestion in adults with xylometazoline hydrochloride 0.1% during the common cold positively impacts QoL factors relevant to daily living [Otrivin: Quality of Life (QoL) Impact in a Real-World Setting; https://clinicaltrials.gov/study/NCT05556148 ].
Pluralising China as method: Between exceptionalism and universalism
Authors: Tsang Ling Tung , Li Xiaotian , Tse Tommy
Published: February 2024

To not only celebrate the launch of this double special issue, but also to shine a spotlight on the variety of China as Method epistemological approaches shared by the special issue’s editors and authors, the Chinese University of Hong Kong’s Hong Kong Institute of Asia Pacific Studies, the University of Amsterdam’s Media Studies Department, and Global Media and China, co-organised a hybrid symposium to generate intellectual exchanges on such a de-westernising mode of knowledge production. While the research articles in this double special issue extensively examine ‘distinct’ characteristics of China, in this introduction, we reflect on if we are essentialising China. We do not want to apply a universalist logic that exists in theories by and from the Global North to be ‘experimented on’ in the Global South; yet, we also seek to move away from ‘China exceptionalism’ and express the stance that China can only be understood in its positionality to other areas (and modes of knowledge production) of the world. Thus, this special issue seeks to further deconstruct China as Method, challenge the existing power imbalance, and pluralise knowledge production.
Role of TNF superfamily members lymphotoxin-α, sCD40L, and TNF-α in endometriosis-related infertility
Authors: Rahmawati Nanda Yuli , Ahsan Fadhil , Santoso Budi , Mufid Alfin Firasy , Sa’adi Ashon , Dwiningsih Sri Ratna , Tunjungseto Arif , Widyanugraha M. Yohanes Ardianta
Published: February 2024

Introduction:

TNF-α, LT-α, and sCD40L belong to the TNF superfamily and play a pivotal role in chronic inflammatory disease. Yet, these soluble molecules are largely unexplored in endometriosis cases with infertility. The present study aimed to evaluate serum and peritoneal fluid levels of these molecules and correlate its level to the endometriosis severity.

Methods:

Peripheral blood and peritoneal fluid samples were obtained from 87 infertility cases who underwent laparoscopy, consisting of 44 endometriotic women and 43 non-endometriotic women. The levels of TNF-α, LT-α, and sCD40L were determined using ELISA.

Results:

Serum and peritoneal TNF-α levels were significantly elevated in the endometriosis group compared to the control group ( p = 0.028; p = 0.027), but not the sCD40L and LT-α level. Serum and peritoneal TNF-α levels were significantly different between late-endometriosis (stage III or IV) compared to the control group ( p = 0.026, p = 0.041, respectively). Moreover, the serum LT-α level was significantly higher in late-endometriosis cases compared to the early-endometriosis (stage I or II) cases ( p = 0.03) and showed a positive correlation with endometriosis rASRM score ( p = 0.001). ROC curve analysis showed a significant diagnostic value of serum LT-α in differentiating the late cases to the early endometriosis patients (AUC = 0.751, p = 0.007). A negative correlation between LT-α and total Endometriosis Fertility Index (EFI) score was also observed ( p = 0.012).

Conclusion:

Severe endometriosis and lower EFI score are associated with higher serum LT-α level. Serum LT-α is a potential staging biomarker among endometriosis cases. Serum and peritoneal TNF-α levels were elevated in women with severe endometriosis among infertility cases. Further study should address the role and predictive value of LT-α in endometriosis-related infertility.
Entrepreneurial Orientation and Innovation Performance of Saudi Firms: A Sequential Mediation Model of Absorptive Capacity and Innovation Capability
Authors: Aloulou Wassim J.
Published: February 2024

This study examines the relationship between entrepreneurial orientation (EO) and innovation performance (IP) using a sequential mediation model of absorptive capacity (AC) and innovation capability (ICAP). We conduct a literature review, develop and test hypotheses using structural equation modelling (SEM) and data collected from 225 Saudi small and medium enterprises (SMEs) operating in several sectors in Saudi Arabia. The findings reveal statistically significant relationships between the EO dimensions (proactive innovativeness and risk-taking) and AC and ICAP. However, no direct relationship is found between the EO dimensions and IP. Therefore, AC mediates the relationship between the EO dimensions and ICAP. In addition, ICAP mediates the relationship between the EO dimensions and AC to IP, while AC does not mediate the relationship between the EO dimensions and IP. To the best of our knowledge, limited research has simultaneously explored the impact of EO, AC, ICAP, and IP in the Saudi context. Our study adds to the existing body of knowledge in the fields of entrepreneurship, innovation, and strategic management by providing empirical evidence specific to the Saudi context. It also displays the significance of managers turning strategic EO dimensions into innovation outcomes through AC and ICAP as a contribution to managerial practices.
Effect of Compressive Shoulder Draping With Adhesive Incise Drape on Soft Tissue Swelling in Shoulder Arthroscopy: A Prospective Randomized Trial
Authors: Uri Ofir , Alfandari Liad , Yaron Ram , Kettanie Amir , Laufer Gil , Behrbalk Eyal
Published: February 2024

Background:

Soft tissue swelling in shoulder arthroscopy is common and may lead to complications. Measures aimed at reducing this phenomenon are routinely used with limited efficacy.

Purpose/Hypothesis:

The purpose of the study was to assess (1) soft tissue swelling of the shoulder (the operated site) and (2) soft tissue swelling of the neck, chest, and arm (the surrounding tissue) in patients with versus without compressive draping during shoulder arthroscopy. It was hypothesized that compressive draping of the shoulder with adhesive incise drape would reduce soft tissue swelling during shoulder arthroscopy.

Study Design:

Randomized controlled trial; Level of evidence, 1.

Methods:

A total of 50 patients undergoing arthroscopic rotator cuff repair were prospectively randomized to either the study group (in which the shoulder was draped with adhesive incise drape tightened around the shoulder) or the control group (in which a standard shoulder arthroscopy drape was used). The circumferences of the shoulder, arm, chest, and neck were measured preoperatively and postoperatively and compared between the groups.

Results:

The shoulder circumference in the standard draping group increased by 16% during the procedure (from 21.2 ± 1.5 cm preoperatively to 24.5 ± 1.7 cm postoperatively) compared with only 6% in the compressive draping group (from 21.0 ± 1.3 cm preoperatively to 22.3 ± 1.1 cm postoperatively) ( P < .01). No serious postoperative complications were observed in either group.

Conclusion:

Compressive shoulder draping with adhesive incise drape was effective in reducing soft tissue swelling around the shoulder in arthroscopic rotator cuff repair compared with standard arthroscopic draping and was not associated with any adverse reactions.

Registration:

NCT03216590 (ClinicalTrials.gov identifier).
A Novel Approach for Evaluating a Schoolwide Antiracist Curriculum Intervention
Authors: Cerda-Smith Jacqueline , Yust Paula K.S. , Weeks Molly S. , Asher Steven R. , Mulvey Kelly Lynn
Published: February 2024

This manuscript describes our effort to apply a novel approach to understanding student outcomes associated with a schoolwide antiracist intervention. We report a multimethod quantitative approach to evaluate a 10-week antiracist intervention designed and implemented by school staff by examining patterns of student intervention engagement and measures of key constructs that connect to antiracism, psychological well-being, and school connectedness. Our novel approach combines schoolwide surveys with smaller samples of daily diary participants, documenting variation in intervention engagement and examining postintervention outcomes. Our findings are limited by high attrition rates, small sample size, and data collection during the COVID-19 pandemic; however, our methods offer a promising transferable approach to evaluate school-based antiracist interventions by examining patterns and predictors of intervention engagement, as well as daily fluctuations in student experience throughout the intervention period.