bluuebunny/crossref_metadata_2025 huggingface dataset:
Distinguishing Incubation and Acute Disease Stages of Mild-to-Moderate COVID-19
Authors: Müller Michael , Volzke Johann , Subin Behnam , Schmidt Christian Johann , Geerdes-Fenge Hilte , Reisinger Emil Christian , Müller-Hilke Brigitte
Published: January 2022

While numerous studies have already compared the immune responses against SARS-CoV-2 in severely and mild-to-moderately ill COVID-19 patients, longitudinal trajectories are still scarce. We therefore set out to analyze serial blood samples from mild-to-moderately ill patients in order to define the immune landscapes for differently progressed disease stages. Twenty-two COVID-19 patients were subjected to consecutive venipuncture within seven days after diagnosis or admittance to hospital. Flow cytometry was performed to analyze peripheral blood immune cell compositions and their activation as were plasma levels of cytokines and SARS-CoV-2 specific immunoglobulins. Healthy donors served as controls. Integrating the kinetics of plasmablasts and SARS-CoV-2 specific antibodies allowed for the definition of three disease stages of early COVID-19. The incubation phase was characterized by a sharp increase in pro-inflammatory monocytes and terminally differentiated cytotoxic T cells. The latter correlated significantly with elevated concentrations of IP-10. Early acute infection featured a peak in PD-1+ cytotoxic T cells, plasmablasts and increasing titers of virus specific antibodies. During late acute infection, immature neutrophils were enriched, whereas all other parameters returned to baseline. Our findings will help to define landmarks that are indispensable for the refinement of new anti-viral and anti-inflammatory therapeutics, and may also inform clinicians to optimize treatment and prevent fatal outcomes.
Immunogenicity of The BNT162b2 COVID-19 mRNA and ChAdOx1 nCoV-19 Vaccines in Patients with Hemoglobinopathies
Authors: Radhwi Osman O. , Jan Hamza , Waheeb Abdullah , Alamri Sawsan S. , Alahwal Hatem M. , Denetiu Iuliana , Almanzlawey Ashgan , Al-Marzouki Adel F. , Almohammadi Abdullah T. , Bahashwan Salem M. , Barefah Ahmed S. , Qari Mohamad H. , Abuzenadah Adel M. , Hashem Anwar M.
Published: January 2022

Introduction: Studies assessing immune responses following Pfizer-BioNTech BNT162b2 mRNA COVID-19 (Pfizer) and ChAdOx1 nCoV-19 AZD1222 (AstraZeneca) vaccines in patients with hemoglobinopathy are non-existent in the literature despite being thought at high risk of infection. Methods: Prospectively, we collected serum from patients with hemoglobinopathies at least 14 days post vaccine and measured neutralizing antibodies (nAb) in addition to binding antibodies using in-house assays. Results: All 66 participants mounted a significant binding antibody response (100%), but nAbs were detected in (56/66) post-vaccine with a rate of 84.5%. Age, gender, vaccine type, spleen status, hydroxyurea use, and hyperferritinemia did not affect the rate significantly. While 23/32 (71.8%) patients receiving only one dose of the vaccine were able to mount a positive response, 33/34 (97.05%) of those who had two doses of any vaccine type had a significant nAbs response. Patients who had anti-nucleocapsid (N), signifying asymptomatic infection in the past, were able to produce nAbs (31/31). No nAbs were detected in 10/35 (28.5%) patients with no anti-N antibodies. Conclusion: Our results provide supportive data when advising patients with hemoglobinopathy to receive COVID-19 vaccines and ensure booster doses are available for better immunity. Whenever available, measurement of nAb is recommended.
Monitoring of SARS-CoV-2 Specific Antibodies after Vaccination
Authors: Guiomar Raquel , Santos Ana João , Melo Aryse Martins , Costa Inês , Matos Rita , Rodrigues Ana Paula , Kislaya Irina , Silva Anabela Santos , Roque Carla , Nunes Carla , Aguiar Joaquim , Graça Fátima , Silva Graça Antônio , Machado Ausenda
Published: January 2022

Vaccination is considered the most important measure to control the COVID-19 pandemic. Extensive follow-up studies with distinct vaccines and populations are able to promote robust and reliable data to better understand the effectiveness of this pharmacologic strategy. In this sense, we present data regarding binding and neutralizing (achieved by surrogate ELISA assay) antibodies throughout time, from vaccinated and previously infected (PI) health care workers (HCW) in Portugal. We analyzed serum samples of 132 HCW, who were vaccinated and with previous SARS-CoV-2 infection. Samples were collected before vaccination (baseline, M1), at second dose vaccine uptake (M2), and 25–70 days (M3) and 150–210 days (M4) after the second dose for vaccinated individuals. The IgG (anti-RBD/S) antibody geometric mean titers found on vaccinated HCW at M2 (GM = 116.1 BAU/mL; CI: 92.3–146.1) were significantly higher than those found on PI HCW at recruitment (M1) (GM = 35.9 BAU/mL; CI:15.4–83.4), and the neutralizing antibodies (nAb) were similar between these groups, of 93.2 UI/mL (95% CI 73.2–118.5) vs. 84.1 UI/mL (95% CI 40.4–155.9), respectively. We detected around 10-fold higher IgG (anti-RBD/S) antibodies titers in M3 when compared with M2, with a slight but significant decrease in titers from 36 days after the second dose vaccine uptake. The increase of nAb titers was correlated with IgG (anti-RBD/S) antibodies titers; however, in contrast to IgG (anti-RBD/S) antibodies titers, we did not detect a decrease in the nAb titer 36 days after a second vaccine dose uptake. At M4, a decrease of 8-fold in binding IgG (anti-RBD/S) and nAb was observed. No significant differences in antibody titers were observed by sex, age or chronic diseases. Our results suggest that IgG (anti-RBD/S) antibodies titers and nAb titers could be correlated, but an ongoing follow up of the cohort is required to better understand this correlation, and the duration of the immune response.
Parents’ Willingness to Vaccinate Children against COVID-19 in Saudi Arabia: A Cross-Sectional Study
Authors: Ennaceur Soukaina , Al-Mohaithef Mohammed
Published: January 2022

Objectives: The present study aimed to investigate parents’ willingness to vaccinate their children under the age of 18 with a COVID-19 vaccine. Methods: This cross-sectional study was conducted in Saudi Arabia from January 2021 to March 2021. The univariate analysis using Mann–Whitney U-test, t-test, and chi-squared/Fisher’s exact test was performed to identify sociodemographic factors associated with the acceptance of COVID-19 vaccine in children. Factors with statistical significance (p < 0.05) were analyzed using multivariate regression analysis to determine the variables affecting parents’ decisions to vaccinate children. Results: Overall, 44% (167) of parents reported that they would accept vaccinating their children with a COVID-19 vaccine. Young (86; 22.7%), married (135; 35.6%), and Saudi (114; 30%) parents seemed to be more concerned about their children being infected. Parents who intended to vaccinate themselves (OR: 0.599, 95% CI: 0.367–0.980) and who trust the healthcare system (OR: 0.527, 95% CI: 0.327–0.848) reported greater acceptance of children’s vaccination. Among parents, the most frequent (40.9%) reason for vaccinating children was to prevent infection in other family members. What may underlie this result is that some parents understand that children can carry pathogens from persons in school to thoseat home. The most frequent (22.2%) reason for refusing vaccination was concerns about the side effects of the vaccine. Conclusions: Parents have differing opinions on frequencies and risks of coronavirus disease transmission and medical complications and of effectiveness and adverse effects of a vaccine. These results could be of use in designing public health information campaigns and health promotion programs based on perceived parental behavior and positive attitudes.
Effectiveness of Vaccination against SARS-CoV-2 Infection in the Pre-Delta Era: A Systematic Review and Meta-Analysis
Authors: Meggiolaro Angela , Sane Schepisi Monica , Nikolaidis Georgios F. , Mipatrini Daniele , Siddu Andrea , Rezza Giovanni
Published: January 2022

(1) Background: The objective of this study was to assess the effectiveness of SARS-CoV-2 vaccines in terms of prevention of disease and transmission in the pre-Delta era. The evaluation was narrowed to two mRNA vaccines and two modified adenovirus-vectored vaccines. (2) Methods: The overall risk of any SARS-CoV-2 infection confirmed by positive real-time Polymerase Chain Reaction (PCR) test was estimated in partially and fully vaccinated individuals. The evidence synthesis was pursued through a random-effects meta-analysis. The effect size was expressed as relative risk (RR) and RRR (RR reduction) of SARS-CoV-2 infection following vaccination. Heterogeneity was investigated through a between-study heterogeneity analysis and a subgroup meta-analysis. (3) Results: The systematic review identified 27 studies eligible for the quantitative synthesis. Partially vaccinated individuals presented a RRR = 73% (95%CI = 59–83%) for positive SARS-CoV-2 PCR (RR = 0.27) and a RRR=79% (95%CI = 30–93%) for symptomatic SARS-CoV-2 PCR (RR = 0.21). Fully vaccinated individuals showed a RRR = 94% (95%CI = 88–98%) for SARS-CoV-2 positive PCR (RR = 0.06) compared to unvaccinated individuals. The full BNT162b2 vaccination protocol achieved a RRR = 84–94% against any SARS-CoV-2-positive PCR and a RRR = 68–84% against symptomatic positive PCR. (4) Conclusions: The meta-analysis results suggest that full vaccination might block transmission. In particular, the risk of SARS-CoV-2 infection appeared higher for non-B.1.1.7 variants and individuals aged ≥69 years. Considering the high level of heterogeneity, these findings must be taken with caution. Further research on SARS-CoV-2 vaccine effectiveness against emerging SARS-CoV-2 variants is encouraged.
Nonpharmacological Treatment Strategies for the Management of Canine Chronic Inflammatory Enteropathy—A Narrative Review
Authors: Isidori Marco , Corbee Ronald Jan , Trabalza-Marinucci Massimo
Published: January 2022

Chronic inflammatory enteropathy (CIE) refers to a heterogeneous group of idiopathic diseases of the dog characterised by persistent gastrointestinal (GI) clinical signs. If conventional dietary treatment alone would be unsuccessful, management of CIE is traditionally attained by the use of pharmaceuticals, such as antibiotics and immunosuppressive drugs. While being rather effective, however, these drugs are endowed with side effects, which may impact negatively on the animal’s quality of life. Therefore, novel, safe and effective therapies for CIE are highly sought after. As gut microbiota imbalances are often associated with GI disorders, a compelling rationale exists for the use of nonpharmacological methods of microbial manipulation in CIE, such as faecal microbiota transplantation and administration of pre-, pro-, syn- and postbiotics. In addition to providing direct health benefits to the host via a gentle modulation of the intestinal microbiota composition and function, these treatments may also possess immunomodulatory and epithelial barrier-enhancing actions. Likewise, intestinal barrier integrity, along with mucosal inflammation, are deemed to be two chief therapeutic targets of mesenchymal stem cells and selected vegetable-derived bioactive compounds. Although pioneering studies have revealed encouraging findings regarding the use of novel treatment agents in CIE, a larger body of research is needed to address fully their mode of action, efficacy and safety.
Water Quality Characteristics and Source Analysis of Pollutants in the Maotiao River Basin (SW China)
Authors: Li Yinjiu , Li Qiuhua , Jiao Shulin , Liu Chen , Yang Liuying , Huang Guojia , Zhou Si , Han Mengshu , Brancelj Anton
Published: January 2022

Rivers are an important mediator between human activities and the natural environment. They provide multiple functions, including irrigation, transportation, food supply, recreation, and water supply. Therefore, evaluations of water quality and pollution sources are of great significance for ecological restoration and management of rivers. In this study, the improved “vušekriterijumska optimizacija i kompromisno rješenje” (VIKOR in Serbian; in English: Multicriteria Optimization and Compromise Solution), and a geodetector were used to analyze the water quality characteristics and pollution sources of the Maotiao River Basin (Gizhou province, SW China). The results showed that the water quality of the Maotiao River Basin deteriorated significantly during the summer drought period, as was evident in the reservoirs and lakes. It improved in the wet season (i.e., during the summer period) due to runoff dilution. Water quality decreased along the river’s course, from upstream to downstream sections. The results of the geographic detector analysis showed that agricultural areas were the primary factor affecting the spatial distribution of water quality in the river basin. In July, August, and November 2020, the influence of agricultural land was 0.72, 0.60, or 0.80, respectively, and the interactions among urban, industrial, agricultural, and forested areas explained 99.2%, 83.2%, or 99.9% of the spatial differentiation of water quality, respectively. Due to the influence of spatial scale, settlements have a small influence on the spatial distribution of water quality. Their impact factors were 0.38, −0.24, and −0.05, respectively. Notably, the negative relationship of water quality and forested areas reflects that topography, types of landscapes, and soil thickness have considerable influences on the Maotiao River Basin’s water quality. Based on the findings, we infer that good farmland water conservancy projects and comprehensive management of different types of landscapes, such as forests, agriculture, and urban area and water bodies, are of great significance for improving water quality.
Sustainable Surface Water Storage Development: Measuring Economic Benefits and Ecological and Social Impacts of Reservoir System Configurations
Authors: Eriyagama Nishadi , Smakhtin Vladimir , Udamulla Lakshika
Published: January 2022

This paper illustrates an approach to measuring economic benefits and ecological and social impacts of various configurations of reservoir systems for basin-wide planning. It suggests indicators and examines their behavior under several reservoir arrangement scenarios using two river basins in Sri Lanka as examples. A river regulation index is modified to take into account the volume of flow captured by reservoirs and their placement and type. Indices of connectivity illustrate that the lowest river connectivity in a basin results from a single new reservoir placed on the main stem of a previously unregulated river between the two locations that command 50% and 75% of the basin area. The ratio of the total affected population to the total number of beneficiaries is shown to increase as the cumulative reservoir capacity in a river basin increases. An integrated index comparing the performance of different reservoir system configurations shows that while results differ from basin to basin, the cumulative effects of a large number of small reservoirs may be comparable to those with a few large reservoirs, especially at higher storage capacities.
Estimation of Scottish Pluvial Flooding Expected Annual Damages Using Interpolation Techniques
Authors: Viavattene Christophe , Fadipe David , Old Jodi , Thompson Vikki , Thorburn Kirsten
Published: January 2022

Flood modelling and mapping, underpinned by hydraulic modelling, are typically used to define flood hazard and allow a quantification of risk and associated Expected Annual Damages (EAD). At a regional or national scale, such modelling is often a lengthy process, which does not allow changes in risk resulting from new science such as revised rainfall frequency estimates or climate projections to be readily quantified by policy makers. A framework of interpolation and extrapolation methods has been developed in the R language via practical application to the city of Perth in central Scotland. These methods allow existing flood mapping, design rainfall estimates and property receptor datasets combined with revised design rainfall estimates to be used to rapidly assess the consequences of change in risk and EAD. The results are evaluated against detailed hydraulic modelling and are shown to provide a good approximation of changes in flood depth and EAD for properties previously modelled as at risk of flooding, particularly residential properties, with lower confidence for non-residential properties. In the Scottish context, the methods are considered to be robust for regional and national scale application and would allow policy makers with a means to rapidly determine the consequence of changes in design rainfall estimates without the immediate requirement to undertake complex hydraulic modelling.
A Study to Investigate What Tempts Consumers to Adopt Electric Vehicles
Authors: Ali Imran , Naushad Mohammad
Published: January 2022

Pollution has become a major source of concern for the majority of people at present. Pollution is primarily caused by automobiles. Everybody wants to live in a pollution-free society. Nevertheless, India’s automobile registrations are growing at a rapid pace. Increased automobile usage will have a negative effect on the environment. As a result, our modes of transportation must be sustainable and environmentally friendly. The solution to this dilemma is electric vehicles. However, electric vehicle adoption is not occurring at a rate that is desirable in India, although it is anticipated to grow in the coming years. Numerous automobile manufacturers are ramping up production of electric automobiles. The purpose of this study is to ascertain the primary factors that influence the adoption of electric vehicles. This study includes five independent variables: financial incentives, charging infrastructure, social reinforcement, environmental concern, and price, and one dependent variable, electrical vehicle adoption. The data for the present study was collected from 366 randomly selected respondents across India. Structural Equation Modeling (SEM) and Confirmatory Factor Analysis (CFA) were used to analyze the data. The study’s findings demonstrate that pricing has a substantial impact on the adoption of electric vehicles.
Bone regeneration biomarkers in maxillofacial surgery: a critical review of literature
Authors: Kosach G. A. , Kutukova S. I. , Vlasov T. D. , Yaremenko A. I.
Published: January 2022

Relevance. Drug-associated osteonecrosis is known to cause some pathological changes. The titers of biomarkers responsible for bone metabolism are also subject to such changes. They are essential in the diagnosis and treatment planning, especially during surgical interventions, because of the risk of osteonecrosis. Purpose – based on the data of modern scientific literature and articles, identifying markers of bone remodeling and endothelial disorders is of primary importance for optimizing the early diagnosis of microcirculati on disorders in patients with maxillofacial pathologies.Materials and methods. A review of available data in the literature on normal bone anatomy, bone biomarkers, and regulatory factors. The study of diagnostic modes and identification of the most valuable and fastest in bone and vascular endothelium impairment.Results. According to the studies, osteocalcin, C-terminal telopeptide, tartrate-resistant acid phosphatase and VEGF are clinically the most informative for predicting jawbone osteonecrosis. With a serum C-terminal telopeptide concentration of less than 100 pg/mL, the risk of osteonecrosis increases. Serum osteocalcin is a specific biomarker of osteoblast function for assessing the rate of bone formation in osteoporosis. The average osteocalcin level revealed a significant difference between postmenopausal osteoporotic (16.16 ± 4.5 ng/ml) and non-osteoporotic (11.26 ± 3.07 ng/ml) women. Tartrate-resistant acid phosphatase (TRAP 5b) is used to reference the activity and number of osteoclasts. TRAP 5b can be specifically detected in serum by immunoassays.Conclusion. The study of bone degeneration markers and vascular markers allows us to understand the principles of the occurrence of osteonecrosis more clearly, and, therefore, more clearly predict, diagnose osteonecrosis, and also correctly select the tactics of treatment for these patients, the type of surgical intervention, conservative, operative (partial resection, total jaw resection), – palliative, pre- and post-drug preparation of the body for intervention.
PENERAPAN METODE HOUSE OF RISK PADA SISTEM INFORMASI MANAJEMEN RISIKO PROYEK DI CV ABC
Authors: Satria Yuda , Lubis Riani
Published: January 2022

CV ABC merupakan sebuah perusahaan yang bergerak di bidang jasa khususnya kontruksi. Pada setiap proyek yang telah dilaksanakannya, CV ABC belum menggunakan pengendalian risiko proyek dalam menunjang pelaksanaan kegiatan proyek. Oleh karena itu, tidak adanya pengendalian risiko proyek akan menyebabkan terjadinya penyimpangan aktivitas. Dalam hal ini, site manajer akan sulit untuk mengidentifikasi risiko proyek dan urutan prioritas mitigasi yang harus dilakukan. Maka dari itu diperlukan sebuah sistem informasi manajemen risiko proyek, yang dapat membantu site manajer dalam mengidentifikasi kemungkinan terjadinya risiko pada sebuah proyek yang akan berjalan dan membantu dalam penentuan prioritas mitigasi yang digunakan untuk mencegah terjadinya risiko ketika pelaksanaan kegiatan proyek. Pada penelitian ini metode yang digunakan untuk manajemen risiko proyek adalah metode house of risk (HOR) dengan tahapan identifikasi risiko, analisis risiko, evaluasi risiko, dan risk response (mitigasi). Berdasarkan implementasi dan pengujian dengan menggunakan Black-Box dan metode User Acceptance Test (UAT), maka dapat ditarik kesimpulan bahwa sistem informasi manajemen risiko proyek yang di bangun dapat membantu site manajer dalam mengidentifikasi risiko, dan menentukan prioritas mitigasi yang digunakan untuk mencegah terjadinya risiko ketika pelaksanaan kegitan proyek.
Social media projects for boosting intercultural communication by means of learning English
Authors: Fomenko Tatiana , Bilotserkovets Marina , Sbruieva Alina , Kovalenko Andrij , Bagatska Olena
Published: January 2022

The paper is targeted to explore the intensification of communication among culturally diverse students by means of creating social media groups. In frames of the psycholinguistic experiment, Ukrainian and Chinese students were working together at detecting common, similar and distinct features in idioms from the Ukrainian, English and Chinese languages. They intented to decode the phraseological picture of the world of Ukrainian, English and Chinese. Participation in social media group enabled participants’ exchanging opinions and ideas in the process of learning English. Such intercultural interaction outlined the national-axiological characteristics of Ukrainian, Chinese and English, their outlook and behavioral patterns. Pedagogical observation and interviews with participants revealed that students, who participated in the social media project, learnt traditions, speech etiquette and social norms of other nations, fostered their English speaking and writing skills. It was noted that democratic, uncritical and open-minded style of communication in the social media group allowed participants to build informal cooperation, develop tolerance to fellow students, overcome self-doubt and get motivated to communicate with culturally diverse students.
Legal aspects of civil-military cooperation in comparative context
Authors: Lutsenko Yuriy , Tarasiuk Anatolii , Kryzhna Valentyna , Motyl Victor , Dimich Antonina
Published: January 2022

The goal of the research paper is to study, with active reference to the comparative legal method, Ukrainian and foreign models of civil-military cooperation (CIMIC). The following scientific methods have been used to study chosen military-legal issues, substantiate the theses expressed by the authors, and formulate conclusions: historical-legal, system analysis, formal-logical and method of comparison. It has been determined that CIMIC concept remains novel for both Ukrainian military and civil society in general at the current stage of national, political and defense development; in fact, CIMIC doctrine is also a relatively new phenomenon in the military doctrine and standards of NATO member states.

Based on the results of the study, it has been argued that Ukrainian CIMIC doctrine of the Central Command as a program document in a certain direction should further focus on the following areas: 1) development of a culture of mutual respect, trust and support between all involved military and non-military actors; 2) promotion of patriotic education in Ukrainian society, protection of the rights and freedoms of members of the Central Election Commission; 3) use of CIMIC units as a platform for civil-military contact and cooperation in eastern Ukraine, especially in the area of the Joint Forces Operation; 4) promotion of legal guarantees of gender equality and equal opportunities for men and women in the Armed Forces of Ukraine.
Problem aspects of interaction of law enforcement authorities in the field of countering money laundering
Authors: Reznik Oleg , Bondarenko Olha , Horobets Nadiia , Kostenko Andriana , Nazarov Mykola
Published: January 2022

One of the biggest obstacles to maintaining an effective international financial system is money laundering. Money laundering is also extremely difficult to investigate and prosecute. The latter task is entrusted to law enforcement agencies. The purpose of the article is to characterize the problematic aspects of law enforcement cooperation in the field of combating money laundering in Ukraine and finding optimal ways to solve them. During the study, the authors used the following methods: dialectal, terminological analysis and operationalization of concepts, analysis and refinement, analysis, and synthesis, sociological and statistical. The article emphasizes that the normative sources of ways of interaction between law enforcement agencies in the field of combating money laundering are set out in a rather fragmentary manner, without any specifics regarding the specific boundaries, scope of cooperation. This situation inevitably leads to various kinds of abuse and conflict. In our opinion, given the importance of the task of combating money laundering, the main task is to clearly regulate the ways and methods of cooperation between law enforcement agencies in this area and the introduction of administrative liability for failure to take measures or evasion of such cooperation.
Mechanism of administrative and legal regulation of the use of personal data by local governments
Authors: Bukhanevych Oleksandr , Koropatnik Igor , Zubov Oleksandr , Lytvyn Nataliia , Havrylyuk Ruslana
Published: January 2022

The article is devoted to studying the peculiarities of the mechanism of administrative and legal regulation of the use of personal data by local governments. The authors focus on the organizational, legal, and administrative-procedural principles of using personal data by local governments in Ukraine. The international experience of legal regulation of personal data use is analyzed. The purpose of the study was to determine the characteristics of the mechanism of administrative and legal regulation of the use of personal data by local governments. According to the purpose, the object of the study is the public relations that arise in the field of the use of personal data by local governments. And the subject of the study is the mechanism of administrative and legal regulation of such use. The methodological basis of the study is a set of general and unique methods of cognition, in particular: dialectical, historical, descriptive, methodology of scientific analysis, and generalization - comparative law, structural-functional and analytical. The authors made conclusions that to improve national legislation, Ukraine, under its obligations under the Association Agreement with the EU, must implement mechanisms for the appropriate level of protection of personal data.
Digital technology implementation in students’ proficiency development for english listening
Authors: Kostikova Ilona , Oleksandr Chastnyk Oleksandr Chastnyk , Ptushka Anastasiia , Yazlovytska Olena , Dovzhenko Olga
Published: January 2022

The article proposes a research that shows digital technology for developing students’ proficiency in listening comprehension using the offered Internet resources, the created learning site and well-known on-line apps as it is aimed. The research methods has been used to demonstrate the finding of the paper: the questionnaires in order to analyze students’ attitude to learning with sites; tests for getting students’ progress in developing listening competence; Student’s t-test as a statistical method to estimate the results of pedagogical experiment. In general, 88 universities students took part in this research during 2020-2021. As a conclusion we can state that listening competence is less ready to progress. The present research opens the perspectives for further researches of developing English listening proficiency on-line.
IMPLEMENTATION OF CERTAINTY FACTOR IN AN EXPERT SYSTEM FOR DIAGNOSING ORAL CANCER
Authors: Nugroho Nurhasan , Handayani Nurdiana , Destriana Rachmat , Ernawati Tia
Published: January 2022

Oral cancer or oral cavity cancer is cancer that attacks the epithelial tissue of the oral mucosa. Cancer is a disease with a high mortality rate. Therefore, it is very important to be able to provide knowledge assistance to people who are still quite low in knowledge about cancer, especially oral cancer. One way to help diagnose disease is to use an expert system. In this study, an expert system application was developed to diagnose oral cancer based on symptoms and produce a diagnosis and treatment solution. The expert system developed using the certainty factor algorithm (CF). Where is able to overcome uncertainty by providing a value level of trust from experts and users. From the results of the accuracy test, it shows a value of 87%, so the system can function properly.
HYDROGEN PRODUCTION BY ELECTROLYSIS OF WATER FROM POLYMER ELECTROLYTE MEMBRANE (PEM)
Authors: Тарамов Ю. Х. , Ахъядов Р. И. , Эльмурзаев А. А.
Published: January 2022

В современном мире с ростом населения и уровня жизни потребление энергии постепенно увеличивается. Наряду с этим, с усилением глобального потепления и загрязнения окружающей среды становится все более важным развитие альтернативных источников энергии. Одним из таких источников глобальной энергии является водород. Водород является одним из наиболее многообещающих экологически чистых и устойчивых энергоносителей, и в качестве побочного продукта он выделяет только воду, без каких-либо выбросов углерода. Неуклонно растущие глобальные потребности в энергии и ограниченные запасы ископаемого топлива вместе с устойчивостью и воздействием на окружающую среду требуют разработки новых энергетических подходов без каких-либо выбросов углерода и негативных веществ. Среди многих методов производства водорода экологически чистый водород высокой чистоты (99,9%) можно получить путем электролиза воды для получения чистого водорода и кислорода.

In the modern world, with the growth of population and living standards, energy consumption is gradually increasing. Along with this, with the increase in global warming and environmental pollution, the development of alternative energy sources becomes more and more important. Hydrogen is one such source of global energy. Hydrogen is one of the most promising green and sustainable energy sources, and it releases only water as a by-product without any carbon emissions. The steadily growing global energy demand and limited fossil fuel reserves, together with sustainability and environmental impact, require the development of new energy approaches without any carbon and negative substances. Among the many methods of hydrogen production, environmentally friendly high purity hydrogen (99.9%) can be obtained by electrolysis of water to produce pure hydrogen and oxygen.
METHODOLOGICAL ASPECTS OF STUDENTS ETHNOCULTURAL COMPETENCE FORMATION IN PEDAGOGICAL UNIVERSITIES
Authors: Базаева Ф. У.
Published: January 2022

В статье рассматриваются методологические вопросы формирования этнокультурной компетентности будущих педагогов, подчеркивается роль системы образования в этнокультурном воспитании подрастающего поколения, обосновывается актуальность этнокультурного подхода в образовании в современных условиях. Проводится анализ структуры и содержания понятия этнокультурной компетентности, рассматриваются различные аспекты и виды этнокультурной компетентности, анализируются требования к этнокультурной компетентности с точки зрения профессиональной готовности педагога. Особое внимание уделяется понятию этнического самосознания, рассматриваемого в качестве основного показателя сформированности этнокультурной компетентности. Перечислены основные принципы педагогической работы по развитию этнического самосознания и формированию этнокультурной компетентности студентов педагогических вузов, описаны направления учебно-воспитательной работы и условия ее эффективности.

The article examines the methodological issues of the formation of the ethnocultural competence of future teachers, emphasizes the role of the education system in the ethnocultural education of the younger generation, substantiates the relevance of the ethnocultural approach to education in modern conditions. The analysis of the structure and content of the concept of ethnocultural competence is carried out, various aspects and types of ethnocultural competence are considered, the requirements for ethnocultural competence are analyzed from the point of view of the teacher’s professional readiness. Special attention is paid to the concept of ethnic self-awareness, considered as the main indicator of the formation of ethnocultural competence. The main principles of pedagogical work on the development of ethnic self-awareness and the formation of ethnocultural competence of students of pedagogical universities are listed, directions of educational work and the conditions for its effectiveness are described.
THE IMPACT OF CORONACRISIS ON THE SECTOR OF MICRO-, SMALL AND MEDIUM-SIZED ENTERPRISES
Authors: Абуев А. И. , Барзаева М. А.
Published: January 2022

В сложившихся на сегодняшний момент времени условиях пандемии в экономической среде наиболее подвержены негативному проявлению кризиса предприятия малого и среднего бизнеса. Государственная поддержка охватывает все сферы его функционирования, выступая надежным гарантом реализации его социально-экономической значимости в формировании здоровой экономической среды. К сожалению, при выполнении функции самостоятельного ведения бизнеса микро-, малые и средние предприятия (ММСП далее) сталкиваются со множеством проблем. Нередко в числе основных проблем системы регулирования ММСП в России указывают на низкий уровень финансирования, проблемы регулирования нормативно-правового характера, уровень коррумпированности региональных и федеральных чиновников, нехватку знаний в сфере ведения бизнеса и ряд других. Тем не менее, как показывает опыт, ММСП является действенным механизмом ключевых преобразований не только региональных экономик, но и мировой экономики в целом.

Under the current conditions of a pandemic in the economic environment, small and medium-sized businesses are most susceptible to the negative manifestation of the crisis. State support covers all spheres of its functioning, acting as a reliable guarantor of the implementation of its socio-economic significance in the formation of a healthy economic environment.Unfortunately, micro, small and medium-sized enterprises (MSMEs hereinafter) face many challenges when performing the function of self-running business. Often, among the main problems of the MSME regulation system in Russia, they point out the low level of funding, regulatory problems, the level of corruption of regional and federal officials, a lack of knowledge in the field of starting a business, and a number of others.Nevertheless, experience shows that MSMEs are an effective mechanism for key transformations not only of regional economies, but also of the global economy as a whole.
Development of roughness and decrease in hardness of abrasive wear surface in various types of polyethylene. Part I.
Authors: Gumen V. R. , Kovriga V. V.
Published: January 2022

Samples of eight grades of polyethylene from various manufacturers: PE100 2NT11-9 (Kazanorgsintez plant); Hostalen CRP-100 with increased resistance to cracking, PE 100RC, Hostalen 4731 PG - powder (LyondellBasell); PERT I and II type Dowlex 2344 and Dowlex 2377 (Dow); PE100 P6006 AD (Sabic); PE100 H1000PC (SCG, Thailand) tested for wear according to the ISO 9352 method with the determination of the roughness and hardness of the wear mark. A range of materials with consistently decreasing wear resistance have been identifi ed. It is shown that wear occurs in layers. The presence of layers does not change the position of materials in the range of wear resistance. A decrease in the hardness of materials under the wear surface is shown. The dependence of the roughness on the grain size of the abrasive is investigated.
Research Institute of Plastics  the birthplace of structural thermoplastics in Russia and specialists in the plastics processing industry
Authors: Katsevman M. L.
Published: January 2022

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Obtaining and studying the properties of composites based on high pressure polyethylene with cobalt-containing nanofi llers
Authors: Kurbanova N. I. , Mirzoeva N. A. , Ishenko N. Ya. , Zeynalov E. B.
Published: January 2022

The effect of cobalt nanoparticles stabilized by a polyethylene matrix on the physical-mechanical and thermal properties of nanocomposites based on low density polyethylene was studied using X-ray phase (XRD) and differential thermal (DTA) analyzes.

An improvement in the strength and deformation parameters, as well as the thermal-oxidative stability of the obtained nanocomposites was revealed, which can be attributed to the effects of structural modification of the polymer matrix.

Small amounts of nanofiller introduced into the polymer play the role of structure-forming agents - artificial nuclei of crystallization, which contributes to the formation of a small-spherolite structure in the polymer, characterized by improved physical, mechanical and thermal properties of the obtained nanocomposite.
Percepción de los profesores sobre los juegos web y dispositivos móviles en el nivel educativo superior durante la pandemia COVID-19
Authors: Salas-Rueda Ricardo-Adán , Ramírez-Ortega Jesús , Eslava-Cervantes Ana-Libia , Castañeda-Martínez Ricardo , De-La-Cruz-Martínez Gustavo
Published: January 2022

El virus SARS-CoV-2 ha provocado que las universidades busquen nuevas alternativas tecnológicas con el propósito de mejorar la enseñanza y el aprendizaje bajo la modalidad a distancia. Esta investigación cuantitativa y cualitativa analiza la percepción de los educadores sobre los juegos web y dispositivos móviles durante la pandemia COVID-19 considerando la técnica aprendizaje automático y la técnica árbol de decisión (ciencia de datos). Los participantes son 60 docentes de educación superior que impartieron cursos en la Universidad Nacional Autónoma de México en el año 2021 y tomaron el Diplomado “Innovación en la Docencia Universitaria 2021”. La técnica aprendizaje automático indica que el uso de los juegos web y dispositivos móviles influyen positivamente la labor docente y participación de los estudiantes durante el proceso de enseñanza-aprendizaje. Además, la ciencia de datos establece 4 modelos predictivos sobre estas herramientas tecnológicas a través de la técnica árbol de decisión. Por último, los juegos web y dispositivos móviles permiten la creación de nuevos espacios virtuales que favorecen la enseñanza bajo la modalidad a distancia y facilitan el aprendizaje desde cualquier lugar.
Radiation robustness of laser ceramics and single crystal for microchip laser remote analysis
Authors: Tamura Koji , Nakanishi Ryuzo , Ohba Hironori , Taira Takunori , Wakaida Ikuo
Published: January 2022

Laser pulse energy and pulse build-up time were measured during gamma irradiation at a dose rate of 150 Gy h−1 to evaluate the radiation-induced effects and robustness on a laser remote inspection system using ceramics and single crystal microchip laser. Results showed a time-dependent decrease in pulse energy and an increase in pulse build-up time during irradiation. Both effects were larger for ceramics than for single crystals due to the amount of generated optical loss. The behaviors of pulse energy and build-up time with the increase in optical loss in the gain medium were simulated using rate equation calculations. The radiation effect on build-up time was larger than that on pulse energy for both specimens. Therefore, build-up time measurement is highly sensitive and effective for the evaluation of the radiation effect generated in laser medium, especially for radiation robust specimens or at low radiation dose rate.
Gender pairings in EFL child task-based interaction
Authors: Martínez-Adrían María , Gutiérrez-Mangado María juncal
Published: January 2022

Few studies have tackled gender differences in second language (L2) interaction, and particularly, the effect of gender pairings on learning opportunities operationalized as Language Related Episodes (LREs) has been scarcely looked into (see Azkarai, 2015b; Azkarai & García-Mayo, 2012; Ross-Feldman, 2005, 2007). Additionally, these studies have targeted adult L2 learners and to our knowledge, no studies so far have been conducted with children. This paper will try to fill these gaps by analysing the effect of gender pairings on the occurrence, nature and resolution of LREs in a storytelling task performed by 10-12-year-old children. More specifically, it explores whether there are any differences between same-gender and gender-mismatched dyads, and between same-gender dyads (male-male vs female-female). Results show that type of pairing affects LRE production and resolution as more LREs were initiated and resolved in matched-gender dyads than in mixed-gender dyads. However, gender-pairing did not influence the outcome of the resolution, as a still low rate of targetlikeness was obtained in mixed- and matched-gender dyads. Additionally, no statistically significant differences were obtained between same-gender dyads, but female-female dyads were found to be more concerned with getting the message across and oriented to higher accuracy in the resolutions of meaning-related episodes.
UJI EFEKTIFITAS GEL EKSTRAK ETANOL KULIT BATANG KAYU JAWA (Lannea coromandelica) PADA KELINCI (Oryctolagus Cuniculus) SEBAGAI OBAT LUKA BAKAR
Authors: Muin Rahmatullah
Published: January 2022

Telah dilakukan penelitian mengenai gel ekstrak kulit batang kayu jawa (Lannea Coromandelica). Tujuan penelitian ini untuk mengetahui apakah gel estrak kulit batang kayu jawa (Lannea Coromandelica) dapat memberikan efek obat luka pada kelinci. Penelitian ini dilakukan dengan menggunakan gel ekstrak kulit batang kayu jawa (Lannea Coromandelica) dengan kosentrasi ekstrak 3%,basis gel(tanpa ekstrak) dan bioplacenton. Hasil penelitian yang telah dilakukan diperoleh rata-rata hari dimana luka mulai mengering yaitu ketiga sediaan memberikan efek terhadap luka. Efek paling optimum adalah sediaan gel dengan ekstrak kulit batang kayu jawa (Lannea Coromandelica) konsentrasi 3%, ini ditandai dengan luka mengering pada hari ke-5, untuk sediaan Bioplacenton® luka mengering pada hari ke-6, sedangkan sediaan gel tanpa ekstrak luka mulai mengering pada hari ke-8.
PENGARUH KECERDASAN MATEMATIS LOGIS MAHASISWA TERHADAP KEMAMPUAN PENALARAN DASAR MATEMATIKA DAN STATISTIKA FARMASI
Authors: Soewandi Andi , Rachmaulidya Ainaya , Apriliano W Bagas , Nur Prana Muhammad
Published: January 2022

Kemampuan bernalar sangat dibutuhkan bagi siswa maupun mahasiswa dalam memahami materi atau konsep matematika dan statistika. Penelitian ini merupakan penelitian penelitian asosiatif denganpendekatan kuantitatif. Dalam penelitian ini, peneliti membahas pengaruhkecerdasan matematislogis terhadap kemampuan penalaran yang data-datanya dihitung secara kuantitatif. Sampel penelitian seluruh mahasiswa farmasi semester 1 yang terdiri dari 42 mahasiswa. Metode pengumpulan data yang digunakan adalah tes, wawancara,observasi, dan dokumentasi. Teknik analisis data yang digunakanadalah analisis regresi linier sederhana. Hasil penelitian menunjukkan bahwa tingkat kecerdasan matematis logis mahasiswa farmasi semester 1 tahun Ajaran 2017/2018 sebagian besar berada padakategori sedang dengan presentase sebesar 66,67% sedangkan tingkat kemampuan penalaran dasar sebagian besar juga berada pada kategori sedang dengan persentase sebesar73,81%. disimpulkan bahwa kecerdasan matematis logis berpengaruh sebesar 19,67% terhadap kemampuan penalaran dasar mahasiswa farmasi semester 1 Universitas Peradaban sedangkan sisanya 80,33% dipengaruhi oleh faktor lain.
PENGGUNAAN OBAT GASTRITIS GOLONGAN PROTON PUMP INHIBITOR PADA PASIEN RAWAT JALAN DI RUMAH SAKIT LABUANG BAJI MAKASSAR 2021
Authors: La Sakka La Sakka
Published: January 2022

Penelitian ini bertujuan untuk mengetahui pola penggunaan obat golongan proton pump inhibitor pada pada pasien rawat jalan di RSUD Labuang Baji provinsi Sulawesi selatan. Jenis penelitian ini adalah penelitian deskriptif dengan pendekatan studi kasus yang bertujuan untuk memperoleh gambaran mengenai obat gastritis golongan proton pump inhibitor. Sampel penelitian adalah semua resep di apotek rawat jalan yang mengandung obat golongan proton pump inhibitor (PPI) dan dihitung jumlah obat yang diberikan pada pasien rawat jalan pada bulan Maret-Mei 2021. Hasil penelitian yaitu obat golongan Proton Pump Inhibitor (PPI) yang paling banyak digunakan adalah Omeprazol 64.88% dan Lanzoprazol 35.12% sedangkan Pantoprazol, Rabeprazol dan Esomeprazol sama sekali tidak digunakan. Peresepan obat golongan proton pump inhibitor terbanyak dari poliklinik yaitu poli interna dan kardiologi penyakit dalam dengan persentase 42.06% dan 28.56% sedangkan poli anak sama sekali tidak meresepkan obat golongan proton pump inhibitor (PPI). Hal ini dikarenakan poli interna adalah spesialis medis yang berhubungan dengan berbagai penyakit dan masalah kesehatan yang mempengaruhi organ-organ bagian dalam salah satunya lambung.
Parenting Patterns with Development of Social Adaptation for Toddler Age Children
Authors: Haniarti Haniarti , Juhartina Ariana , Usman Usman
Published: January 2022

Pola asuh orang tua merupakan gambaran tentang sikap dan perilaku orang tua dan anak dalam berinteraksi, berkomunikasi selama mengadakan kegiatan pengasuhan. Tujuan penelitian ini yaitu mengetahui hubungan pola asuh demokratis, otoriter, permisif dengan perkembangan adaptasi anak usia toddler di Posyandu wilayah kerja Puskesmas Bojo Baru Kabupaten Barru. Penelitian ini adalah penelitian survei analitik dengan studi observasional dengan rancangan study cross sectional. Data dianalisis dengan menggunakan uji chi square (x2) dengan tingkat signifikan α = 0,05. Sebanyak 67 responden yang memenuhi criteria penelitian. Uji chi-square (x²) menunjukkan bahwa ada hubungan pola asuh demokratis (p = 0,02), otoriter (p = 0,01), permisif (p = 0,03) dengan perkembangan adaptasi anak usia toddler di Posyandu wilayah kerja Puskesmas Bojo Baru Kabupaten Barru. Berdasarkan hasil penelitian maka disimpulkan bahwa ada hubungan pola asuh demokratis, otoriter, permisif dengan perkembangan adaptasi social anak usia toddler di Posyandu wilayah kerja Puskesmas Bojo Baru Kabupaten Barru.