bluuebunny/crossref_metadata_2025 huggingface dataset:
A Comparison of Methods of Gut Microbiota Transplantation for Preclinical Studies
Authors: Mingaila Jonas , Atzeni Alessandro , Burokas Aurelijus
Published: July 2023

The experimental details reported in preclinical fecal microbiota transplantation (FMT) protocols are highly inconsistent, variable, and/or incomplete. We therefore evaluated FMT from a human donor to antibiotic-induced microbial-depleted mice by exploring the effects of six techniques based on antibiotic (AB) or antibiotic + antimycotic (AB + T) gut decontamination, different administration routes, and different dosing intervals on the gut microbial population, assessed using 16S and 18S sequencing. In addition, we explored the effectiveness of FMT in terms of inflammation, physiological, and behavioral outcomes. Our results showed that intrarectal FMT at low dosing intervals better preserved the donor’s gut bacterial community at genus level. Furthermore, we showed a lower abundance of several genera of fungi in animals treated with AB + T. In addition, we observed that AB + T gut decontamination followed by per os FMT, once every 3 days, affected behavioral parameters when compared to other FMT techniques. Accordingly, the same FMT groups that showed an association with some of the behavioral tests were also related to specific gut fungal genera, suggesting a possible mediation. Our findings may be useful for optimizing the practice of FMT and also in terms of donor microbiota preservation. This information may help to improve the reproducibility and reliability of FMT studies.
Mechanical Comparison between Fenestrated Endograft and Physician-Made Fenestrations
Authors: Jayet Jérémie , Canonge Jennifer , Heim Frédéric , Coggia Marc , Chakfé Nabil , Coscas Raphaël
Published: July 2023

Introduction: A fenestrated endograft (FE) is the first-line endovascular option for juxta and pararenal abdominal aortic aneurysms. A physician-modified stent-graft (PMSG) and laser in situ fenestration (LISF) have emerged to circumvent manufacturing delays, anatomic standards, and the procedure’s cost raised by FE. The objective was to compare different fenestrations from a mechanical point of view. Methods: In total, five Zenith Cook fenestrations (Cook Medical, Bloomington, IN, USA) and five Anaconda fenestrations (Terumo Company, Inchinnan, Scotland, UK) were included in this study. Laser ISF and PMSG were created on a Cook TX2 polyethylene terephthalate (PET) cover material (Cook Medical, Bloomington, IN, USA). In total, five LISFs and fifty-five PMSG were created. All fenestrations included reached an 8 mm diameter. Radial extension tests were then performed to identify differences in the mechanical behavior between the fenestration designs. The branch pull-out force was measured to test the stability of assembling with a calibrated 8 mm branch. Fatigue tests were performed on the devices to assess the long-term outcomes of the endograft with an oversized 9 mm branch. Results: The results revealed that at over 2 mm of oversizing, the highest average radial strength was 33.4 ± 6.9 N for the Zenith Cook fenestration. The radial strength was higher with the custom-made fenestrations, including both Zenith Cook and Anaconda fenestrations (9.5 ± 4.7 N and 4.49 ± 0.28 N). The comparison between LISF and double loop PMSG highlighted a higher strength value compared with LISF (3.96 N ± 1.86 vs. 2.7 N ± 0.82; p= 0.018). The diameter of the fenestrations varied between 8 and 9 mm. As the pin caliber inserted in the fenestration was 9 mm, one could consider that all fenestrations underwent an “elastic recoil” after cycling. The largest elastic recoil was observed in the non-reinforced/OC fenestrations (40%). A 10% elastic recoil was observed with LISF. Conclusion: In terms of mechanical behavior, the custom-made fenestration produced the highest results in terms of radial and branch pull-out strength. Both PMSG and LISF could be improved with the standardization of the fenestration creation protocol.
Current Therapies in Kidney Transplant Rejection
Authors: Alasfar Sami , Kodali Lavanya , Schinstock Carrie A.
Published: July 2023

Despite significant advancements in immunosuppressive therapies, kidney transplant rejection continues to pose a substantial challenge, impacting the long-term survival of grafts. This article provides an overview of the diagnosis, current therapies, and management strategies for acute T-cell-mediated rejection (TCMR) and antibody-mediated rejection (ABMR). TCMR is diagnosed through histological examination of kidney biopsy samples, which reveal the infiltration of mononuclear cells into the allograft tissue. Corticosteroids serve as the primary treatment for TCMR, while severe or steroid-resistant cases may require T-cell-depleting agents, like Thymoglobulin. ABMR occurs due to the binding of antibodies to graft endothelial cells. The most common treatment for ABMR is plasmapheresis, although its efficacy is still a subject of debate. Other current therapies, such as intravenous immunoglobulins, anti-CD20 antibodies, complement inhibitors, and proteasome inhibitors, are also utilized to varying degrees, but their efficacy remains questionable. Management decisions for ABMR depend on the timing of the rejection episode and the presence of chronic changes. In managing both TCMR and ABMR, it is crucial to optimize immunosuppression and address adherence. However, further research is needed to explore newer therapeutics and evaluate their efficacy.
Sustainable Enhancement of the Mechanical and Flammability Performances of Keratinous Feather-PP Composites: The Effects of Processing Temperature and Solvent Choice
Authors: Mishra Avishek , Bhattacharyya Debes
Published: July 2023

This paper discusses two major issues: (i) understanding the influence of the solvent used for fibre processing to obtain flame-retardant chicken feathers, and (ii) establishing the importance of the fibre–matrix blending temperature before composite manufacturing. Three temperature profiles for the extrusion die have been taken into consideration: a low-temperature profile (40 °C) (LT-FRCF), a medium-temperature profile (120 °C) (MT-FRCF), and a high-temperature profile (200 °C) (HT-FRCF). Due to better mixing, the tensile strengths for the medium- and high-temperature profile specimens improved by approximately 44% and 83%, respectively. The cone calorimeter results for the samples with water as the solvent for the feather modification showed a 22% reduction in the peak heat release rate compared to those of the samples with ethanol as the fibre treatment solvent, inferring the importance of the solvent used for the processing and making the process more sustainable with a lower water footprint. The research findings provide clear evidence of how the mixing (extrusion) temperature and choice of solvent for modifying chicken feather fibres affect the composites’ mechanical and flame-retardant properties. These insights contribute to our understanding of how keratinous fibres can effectively serve as flame-retardant reinforcements in polymeric composites.
Influence of Carbon on Additively Manufactured Ti-6Al-4V
Authors: Winkler Kerstin , Seidel Paul , Danzig Andre , Kroll Lothar , Undisz Andreas
Published: July 2023

In this study, the Ti-6Al-4V powder material for additive manufacturing was mixed with amorphous carbon and processed by powder bed fusion using a laser beam. The specimens were subjected to mechanical and microstructural analyses to investigate the impact of the organic constituent that may become introduced unintentionally as an impurity along the powder handling chain. It is documented that hardness and tensile strength increase with increasing carbon content up to 0.2 wt.%. Above this carbon concentration, extensive crack formation in the samples prevents successful procession.
Experimental and Numerical Study of Al2219 Powders Deposition on Al2219-T6 Substrate by Cold Spray: Effects of Spray Angle, Traverse Speed, and Standoff Distance
Authors: Zhang Zheng , Meng Tzee Luai , Lee Coryl Jing Jun , Wei Fengxia , Ba Te , Zhang Zhi-Qian , Pan Jisheng
Published: July 2023

Cold spray (CS) is an emerging technology for repairing and 3D additive manufacturing of a variety of metallic components using deformable metal powders. In CS deposition, gas type, gas pressure, gas temperature, and powder feed rate are the four key process parameters that have been intensively studied. Spray angle, spray gun traverse speed, and standoff distance (SoD) are the other three process parameters that have been less investigated but are also important, especially when depositing on uneven substrates or building up 3D freeform structures. Herein, the effects of spray angle, traverse speed, and SoD during CS deposition have been investigated holistically on a single material system (i.e., Al2219 powders on Al2219-T6 substrate). The coatings’ mass gain, thickness, porosity, and residual stress have been characterized, and the results show that spray angle and traverse speed exercise much more effects than SoD in determining coatings’ buildup. Finite element method (FEM) modeling and computational fluid dynamic (CFD) simulation have been carried out to understand the effects of these three parameters for implementing CS as repairing and additive manufacturing using aluminum-based alloy powders.
Effects of Iron, Lime, and Porous Ceramic Powder Additives on Methane Production from Brewer’s Spent Grain in the Anaerobic Digestion Process
Authors: Syguła Ewa , Rasaq Waheed A. , Świechowski Kacper
Published: July 2023

The process of anaerobic digestion used for methane production can be enhanced by dosing various additive materials. The effects of these materials are dependent on various factors, including the processed substrate, process conditions, and the type and amount of the additive material. As part of the study, three different materials—iron powder, lime, and milled porous ceramic—were added to the 30-day anaerobic digestion of the brewer’s spent grain to improve its performance. Different doses ranging from 0.2 to 2.3 gTS × L−1 were tested, and methane production kinetics were determined using the first-order model. The results showed that the methane yield ranged from 281.4 ± 8.0 to 326.1 ± 9.3 mL × gVS−1, while substrate biodegradation ranged from 56.0 ± 1.6 to 68.1 ± 0.7%. The addition of lime reduced the methane yield at almost all doses by −6.7% to −3.3%, while the addition of iron powder increased the methane yield from 0.8% to 9.8%. The addition of ceramic powder resulted in a methane yield change ranging from −2.6% to 4.6%. These findings suggest that the use of additive materials should be approached with caution, as even slight changes in the amount used can impact methane production.
Study on the Preparation of Network Ti-N/Ti Composites by Nitridation of Ti Powders
Authors: Xiu Ziyang , Ju Boyu , Zhan Junhai , Chen Weidi , Yin Aiping , Zhu Xiaolin , Wang Pengjun , Wu Ping , Yang Wenshu
Published: July 2023

Composite structure design is an important way to improve reinforcement strengthening efficiency. The dispersion of the external reinforcement is often not uniform enough, however, and it is agglomerated in the matrix, which cannot uniformly and effectively bear the load. The interconnected reinforcement network prepared by the in-situ self-growth method is expected to obtain higher material properties. In this paper, the TiN shell was formed on the surface of Ti powder by the in-situ nitriding method, and then the network TiN/Ti composites were prepared by sintering. In the control group, TiN was dispersed by mechanical ball milling, and it was found that TiN powder was coated on the surface of Ti particles, and the sintered TiN/Ti composites formed a discontinuous structure with a great deal of TiN agglomeration. A uniform TiN nitride layer of 5~7 μm was formed on the surface of Ti powder by the in-situ nitriding method, and a connected TiN network was formed in the sintered Ti-N/Ti composites. The composites prepared by nitriding have higher compressive strength, hardness, and plasticity. The hardness of the Ti-N/Ti composite is 685.7 HV and the compressive strength is 1468.5 MPa. On this basis, the influence of the connected TiN structure on the material properties was analyzed, which provided theoretical guidance for the structural design of the network structure-reinforced titanium matrix composites.
Experimental Validation of a Micro-Extrusion Set-Up with In-Line Rheometry for the Production and Monitoring of Filaments for 3D-Printing
Authors: Sousa João , Teixeira Paulo F. , Hilliou Loïc , Covas José A.
Published: July 2023

The main objective of this work is to validate an in-line micro-slit rheometer and a micro-extrusion line, both designed for the in-line monitoring and production of filaments for 3D printing using small amounts of material. The micro-filament extrusion line is first presented and its operational window is assessed. The throughputs ranged between 0.045 kg/h and 0.15 kg/h with a maximum 3% error and with a melt temperature control within 1 °C under the processing conditions tested for an average residence time of about 3 min. The rheological micro slit is then presented and assessed using low-density polyethylene (LDPE) and cyclic olefin copolymer (COC). The excellent matching between the in-line micro-rheological data and the data measured with off-line rotational and capillary rheometers validate the in-line micro-slit rheometer. However, it is shown that the COC does not follow the Cox–Merz rule. The COC filaments produced with the micro-extrusion line were successfully used in the 3D printing of specimens for tensile testing. The quality of both filaments (less than 6% variation in diameter along the filament’s length) and printed specimens validated the whole micro-set-up, which was eventually used to deliver a rheological mapping of COC printability.
ZnO QDs/GO/g-C3N4 Preparation and Photocatalytic Properties of Composites
Authors: Ren Zhixin , Ma Huachao , Geng Jianxin , Liu Cuijuan , Song Chaoyu , Lv Yuguang
Published: July 2023

Using an ultrasound-assisted chemical technique, ZnO quantum dot and ZnO composites were created. The optical characteristics and structural details of these composites were examined using TEM, XRD, XPS, FT-IR, UV-vis, and BET. The results revealed that both the ZnO quantum dot composite and ZnO composite exhibited outstanding optical properties, making them suitable for photocatalytic reactions. In order to analyze the photocatalytic performance, a degradation experiment was conducted using Rhodamine B solution as the simulation dye wastewater. The experiment demonstrated that the degradation of Rhodamine B followed the first-order reaction kinetics equation when combined with the photocatalytic reaction kinetics. Moreover, through cyclic stability testing, it was determined that the ZnO QDs-GO-g-C3N4 composite sample showed good stability and could be reused. The degradation rates of Rhodamine B solution using ZnO-GO-g-C3N4 and ZnO QDs-GO-g-C3N4 reached 95.25% and 97.16%, respectively. Furthermore, free-radical-trapping experiments confirmed that ·O2− was the main active species in the catalytic system and its photocatalytic mechanism was elucidated. The photocatalytic oxidation of ZnO quantum dots in this study has important reference value and provides a new idea for the subsequent research.
Vitamin D—An Effective Antioxidant in an Animal Model of Progressive Multiple Sclerosis
Authors: Haindl Michaela Tanja , Üçal Muammer , Wonisch Willibald , Lang Michaela , Nowakowska Marta , Adzemovic Milena Z. , Khalil Michael , Enzinger Christian , Hochmeister Sonja
Published: July 2023

Vitamin D (VD) is the most discussed antioxidant supplement for multiple sclerosis (MS) patients and many studies suggest correlations between a low VD serum level and onset and progression of the disease. While many studies in animals as well as clinical studies focused on the role of VD in the relapsing-remitting MS, knowledge is rather sparse for the progressive phase of the disease and the development of cortical pathology. In this study, we used our established rat model of cortical inflammatory demyelination, resembling features seen in late progressive MS, to address the question about whether VD could have positive effects on reducing cortical pathology, oxidative stress, and neurofilament light chain (NfL) serum levels. For this purpose, we used male Dark Agouti (DA) rats, with one group being supplemented with VD (400 IE per week; VD+) from the weaning on at age three weeks; the other group received standard rodent food. The rat brains were assessed using immunohistochemical markers against demyelination, microglial activation, apoptosis, neurons, neurofilament, and reactive astrocytes. To evaluate the effect of VD on oxidative stress and the antioxidant capacity, we used two different oxidized lipid markers (anti- Cu++ and HOCl oxidized LDL antibodies) along with colorimetric methods for protective polyphenols (PP) and total antioxidative capacity (TAC). NfL serum levels of VD+ and VD− animals were analyzed by fourth generation single-molecule array (SIMOA) analysis. We found significant differences between the VD+ and VD− animals both in histopathology as well as in all serum markers. Myelin loss and microglial activation is lower in VD+ animals and the number of apoptotic cells is significantly reduced with a higher neuronal survival. VD+ animals show significantly lower NfL serum levels, a higher TAC, and more PP. Additionally, there is a significant reduction of oxidized lipid markers in animals under VD supplementation. Our data thus show a positive effect of VD on cellular features of cortical pathology in our animal model, presumably due to protection against reactive oxygen species. In this study, VD enhanced remyelination and prevented neuroaxonal and oxidative damage, such as demyelination and neurodegeneration. However, more studies on VD dose relations are required to establish an optimal response while avoiding overdosing.
The Interplay between Medical Plants and Gut Microbiota in Cancer
Authors: Caserta Santino , Genovese Claudia , Cicero Nicola , Toscano Valeria , Gangemi Sebastiano , Allegra Alessandro
Published: July 2023

The gut microbiota is a dynamic community of bacteria distributed in the gastroenteric tract and changes in response to diseases, diet, use of antibiotics and probiotics, hygiene status, and other environmental factors. Dysbiosis, a disruption of the normal crosstalk between the host and the microbes, is associated with obesity, diabetes, cancer, and cardiovascular diseases, is linked to a reduction of anti-inflammatory bacteria like Lactobacillus and Roseburia, and to an increase in the growth of proinflammatory species like Ruminococcus gnavus and Bacteroidetes. Some plants possess anticancer properties and various studies have reported that some of these are also able to modulate the gut microbiota. The aim of this work is to evaluate the crucial relationship between medical plants and gut microbiota and the consequences on the onset and progression of cancer. In vivo studies about hematological malignancies showed that beta-glucans tie to endogenous antibeta glucan antibodies and to iC3b, an opsonic fragment of the central complement protein C3, leading to phagocytosis of antibody-targeted neoplastic cells and potentiation of the cytotoxic activity of the innate immune system if administered together with monoclonal antibodies. In conclusion, this review suggests the potential use of medical plants to improve gut dysbiosis and assist in the treatment of cancer.
Characterization of Anticancer Effects of the Analogs of DJ4, a Novel Selective Inhibitor of ROCK and MRCK Kinases
Authors: Kale Vijay Pralhad , Hengst Jeremy A. , Sharma Arati K. , Golla Upendarrao , Dovat Sinisa , Amin Shantu G. , Yun Jong K. , Desai Dhimant H.
Published: July 2023

The Rho associated coiled-coil containing protein kinase (ROCK1 and ROCK2) and myotonic dystrophy-related Cdc-42 binding kinases (MRCKα and MRCKβ) are critical regulators of cell proliferation and cell plasticity, a process intimately involved in cancer cell migration and invasion. Previously, we reported the discovery of a novel small molecule (DJ4) selective multi-kinase inhibitor of ROCK1/2 and MRCKα/β. Herein, we further characterized the anti-proliferative and apoptotic effects of DJ4 in non-small cell lung cancer and triple-negative breast cancer cells. To further optimize the ROCK/MRCK inhibitory potency of DJ4, we generated a library of 27 analogs. Among the various structural modifications, we identified four additional active analogs with enhanced ROCK/MRCK inhibitory potency. The anti-proliferative and cell cycle inhibitory effects of the active analogs were examined in non-small cell lung cancer, breast cancer, and melanoma cell lines. The anti-proliferative effectiveness of DJ4 and the active analogs was further demonstrated against a wide array of cancer cell types using the NCI-60 human cancer cell line panel. Lastly, these new analogs were tested for anti-migratory effects in highly invasive MDA-MB-231 breast cancer cells. Together, our results demonstrate that selective inhibitors of ROCK1/2 (DJE4, DJ-Allyl) inhibited cell proliferation and induced cell cycle arrest at G2/M but were less effective in cell death induction compared with dual ROCK1/2 and MRCKα/β (DJ4 and DJ110).
Overview about Oral Films in Mental Disorders
Authors: Batista Patrícia , Pintado Manuela , Oliveira-Silva Patrícia
Published: July 2023

Mental disorders are increasing worldwide, and efforts have been developed by multidisciplinary research groups to combine knowledge from different areas such as psychology, neuroscience, medicine, and biotechnology to develop strategies and products to promote the prevention of mental disorders. Excessive antipsychotic consumption is a public health problem, and innovative strategies must be devised. The development of innovative and, if possible, natural products is one of the strategies to combat this public health problem. Oral films are recent delivery systems that have been developed with several advantages that should be applied in this area. This review intends to draw attention to these new dosage forms of drugs and bioactive molecules pertinent to the field of mental health prevention and therapy and to the need for regulatory guidelines to ensure their quality and safety. This is a critical overview about strengths, weaknesses, opportunities, and threats related to oral film implementation in mental disorder treatment.
Transdermal Delivery of Glimepiride: A Novel Approach Using Nanomicelle-Embedded Microneedles
Authors: Pervez Sadia , Nasir Fazli , Hidayatullah Talaya , Khattak Muzna Ali , Alasmari Fawaz , Zainab Syeda Rabqa , Gohar Shazma , Tahir Arbab , Maryam Gul e
Published: July 2023

Glimepiride (GM) is a hydrophobic drug that dissolves slowly and yields inconsistent clinical responses after oral administration. Transdermal drug delivery (TDD) is an appropriate alternative to oral administration. Microneedles (MNs) offer a promising delivery system that penetrates the skin, while polymeric micelles can enhance the solubility; hence, the combination of both results in high drug bioavailability. This study aims to improve glimepiride’s solubility, dissolution rate, and bioavailability by incorporating nanomicelles into MNs for TDD. The nanomicelles formulated with 10% Soluplus® (SP) and 40% GM had a mean particle size of 82.6 ± 0.54, PDI of 0.1 ± 0.01, −16.2 ± 0.18 zeta potential, and achieved a 250-fold increase in solubility. The fabricated pyramid shaped GM-dissolving MNs were thermally stable and had no formulation incompatibility, as confirmed by thermal and FTIR analysis. The in vitro dissolution profile revealed that the GM release from nanomicelles and nanomicelle-loaded DMN was concentration-independent following non-Fickian transport mechanism. Improved pharmacokinetic parameters were obtained with dose of 240 µg as compared to 1 mg of GM oral tablet, in healthy human volunteers. The observed Cmax, Tmax and MRT were 1.56 μg/mL ± 0.06, 4 h, and 40.04 h ± 3.37, respectively. The safety profile assessment indicated that microneedles are safe with no adverse effects on skin or health. This study provides an alternative delivery system for the administration of glimepiride, resulting in improved bioavailability, enhanced patient compliance, and reduced dosing frequency.
A Novel Dual-Payload ADC for the Treatment of HER2+ Breast and Colon Cancer
Authors: Mckertish Candice Maria , Kayser Veysel
Published: July 2023

Antibody-drug conjugates (ADCs) have demonstrated a great therapeutic potential against cancer due to their target specificity and cytotoxicity. To exert a maximum therapeutic effect on cancerous cells, we have conjugated two different payloads to different amino acids, cysteines (cys) and lysines (lys), on trastuzumab, which is a humanised anti-HER2 monoclonal antibody. First, trastuzumab was conjugated with monomethyl auristatin E (MMAE), an antimitotic agent, through a cleavable linker (Val-Cit) to prepare ADC (Tmab-VcMMAE). Then, the ADC (Tmab-VcMMAE) was conjugated with a second antimitotic agent, Mertansine (DM1), via a non-cleavable linker Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC) to form a dual conjugate (Tmab-VcMMAE-SMCC-DM1). Our results indicated that the dual-payload conjugate, Tmab-VcMMAE-SMCC-DM1, had a synergistic and superior cytotoxic effect compared to trastuzumab alone. Ultimately employing a dual conjugation approach has the potential to overcome treatment-resistance and tumour recurrences and could pave the way to employ other payloads to construct dual (or multiple) payload complexes.
Value Feelings: A Defense
Authors: Naar Hichem
Published: July 2023

The goal of this paper is to provide an initial defense of a neglected epistemology of value according to which a fundamental mode of access to evaluative facts and properties is constituted by a distinctive kind of feeling, sometimes called ‘value feeling’. The paper defends the appeal to value feelings against some objections that have been leveled against it, objections intended to show that it is a nonstarter. The paper argues that these objections can be met and that the view that there are such value feelings constitutes a reasonable hypothesis.
Electrochemical Crosslinking of Alginate—Towards Doped Carbons for Oxygen Reduction
Authors: Rupar Jelena , Hrnjić Armin , Uskoković-Marković Snežana , Bajuk-Bogdanović Danica , Milojević-Rakić Maja , Gavrilov Nemanja , Janošević Ležaić Aleksandra
Published: July 2023

Electrochemical crosslinking of alginate strands by in situ iron oxidation was explored using a potentiostatic regime. Carbon-based materials co-doped with iron, nitrogen, and/or sulfur were prepared via electrolyte composition variation with a nitrogen-rich compound (rivanol) or through post-treatments with sodium sulfide. Nanometer-sized iron particles were confirmed by transmission and field emission scanning electron microscopy in all samples as a consequence of the homogeneous dispersion of iron in the alginate scaffold and its concomitant growth-limiting effect of alginate chains. Raman spectra confirmed a rise in structural disorder with rivanol/Na2S treatment, which points to more defect sites and edges known to be active sites for oxygen reduction. Fourier transform infrared (FTIR) spectra confirmed the presence of different iron, nitrogen, and sulfur species, with a marked difference between Na2S treated/untreated samples. The most positive onset potential (−0.26 V vs. saturated calomel electrode, SCE) was evidenced for the sample co-doped with N, S, and Fe, surpassing the activity of those with single and/or double doping. The mechanism of oxygen reduction in 0.1 M KOH was dominated by the 2e− reduction pathway at low overpotentials and shifted towards complete 4e− reduction at the most negative explored values. The presented results put forward electrochemically formed alginate gels functionalized by homogeneously dispersed multivalent cations as an excellent starting point in nanomaterial design and engineering.
Effects of Surface Morphology and Type of Cross-Linking of Chitosan-Pectin Microspheres on Their Degree of Swelling and Favipiravir Release Behavior
Authors: Hameed Amer Rashid , Majdoub Hatem , Jabrail Fawzi Habeeb
Published: July 2023

The cross-linked microspheres were prepared and loaded with Favipiravir SARS-CoV-2 antiviral drug, by copolymerization of chitosan (CS) with a polysaccharide extracted from fresh pomegranate peels. Moreover, glutaraldehyde (Glu) has been used as a chemical cross-linker and sodium hexametaphosphate (SHMP) as a physical cross-linker. The extracted polysaccharide was analyzed, and different techniques have been used. The analyses lead to the conclusion that it is pectin. The surface morphology of the prepared microspheres was studied using a scanning electron microscope, where the size and shape factor (S) of the Glu microspheres showed high values (74.27 μm) and (0.852), respectively, meaning their surfaces tend to be rough, whereas the SHMP microspheres showed a smaller size particle (20.47 μm) and a smaller shape factor (0.748), which gives an indication that the SHMP microspheres have smooth surfaces. The swelling studies have shown that Glu microspheres have a higher degree of swelling, which means SHMP microspheres are more compact. The prepared microspheres have shown a higher loading percentage of Favipiravir antiviral drug in SHMP microspheres (37% w/w) in comparison with Glu microspheres (35% w/w), where the electrostatic interaction between the Favipiravir ions and SHMP anions helps for more loading. The microspheres prepared under different types of cross-linking have shown initial burst release of Favipiravir, followed by a step of controlled release for a certain period of time, whose period depends on the pH of the release medium. Both Glu and SHMP cross-linked microspheres have shown high controlled release times in buffered release solutions at pH = 7.4 and for shorter periods at pH = 1.3 and pH = 9.4, which may be related to the type of electrostatic interactions between drug and polymer systems and their reactions with release solution ions.
Reinforcement of Aminopropyl-Terminated Siloxane-Treated Carbon Nanotubes in Epoxy Thermosets: Mechanical and Thermal Properties
Authors: Sun Yuxin , Zhang Xiwen , Zhao Dongyu
Published: July 2023

The synthesis and characterization of aminopropyl-terminated polydimethylsiloxane- treated carbon nanotube (AFCNT)-reinforced epoxy nanocomposites are reported in the current study. The amine functionalization of the CNTs was performed with a reaction to PDMS-NH2. The AFCNTs were homogeneously dispersed in epoxy resin by using an emulsifier and a three-roller mill. The AFCNTs were characterized using Fourier-transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). The curing behavior of the epoxy/AFCNT was studied using a differential scanning calorimeter (DSC). The tensile and impact strengths of the 2.0 wt.% AFCNT-reinforced epoxy nanocomposite were enhanced by 43.2% and 370%, respectively. Moreover, the glass transition temperature (Tg) was also enhanced by 21 °C. Furthermore, significant enhancements were observed in the initial degradation and char yield values. SEM results confirmed that the AFCNTs were highly dispersed in the polymeric matrix.
A Novel Optimal Robust Adaptive Scheme for Accurate GNSS RTK/INS Tightly Coupled Integration in Urban Environments
Authors: Wu Jiaji , Jiang Jinguang , Zhang Chao , Li Yuying , Yan Peihui , Meng Xiaoliang
Published: July 2023

Modern navigation systems are inseparable from an integrated solution consisting of a global navigation satellite system (GNSS) and an inertial navigation system (INS) since they serve as an important cornerstone of national comprehensive positioning, navigation, and timing (PNT) technology and can provide position, velocity, and attitude information at higher accuracy and better reliability. A robust adaptive method utilizes the observation information of both systems to optimize the filtering system, overcoming the shortcomings of the Kalman filter (KF) in complex urban environments. We propose a novel robust adaptive scheme based on a multi-condition decision model suitable for tightly coupled real-time kinematic (RTK)/INS architecture, which can reasonably determine whether the filtering system performs robust estimation (TCRKF) or adaptive filtering (TCAKF), improving the robust estimation method of two factors considering ambiguity variance for RTK-related observations. The performance of the proposed robust adaptive algorithm was evaluated through two sets of real vehicle tests. Compared with the TCAKF and TCRKF algorithms, the new robust adaptive scheme improves the average three-dimensional (3D) position root mean square (RMS) by 31% and 18.88%, respectively. It provides better accuracy and reliability for position, velocity, and attitude simultaneously.
Accurate Maps of Reef-Scale Bathymetry with Synchronized Underwater Cameras and GNSS
Authors: Hatcher Gerald A. , Warrick Jonathan A. , Kranenburg Christine J. , Ritchie Andrew C.
Published: July 2023

We investigate the utility of towed underwater camera systems with tightly coupled Global Navigation Satellite System (GNSS) positions to provide reef-scale bathymetric models with millimeter to centimeter resolutions and accuracies with Structure-from-Motion (SfM) photogrammetry. Successful development of these techniques would allow for detailed assessments of benthic conditions, including the accretion and erosion of reefs and adjacent sediment deposits, without the need for ground control points. We use a multi-camera system towed by a small vessel to map over 70,000 m2 of complex shallow (2–8 m water depth) bedrock reef, boulder fields, and fine (sand and gravel) sediments of Lake Tahoe, California. We find that multiple synchronized cameras increase overall mapping coverage and allow for wider survey line spacing. The accuracy of the techniques was sub-millimeter for local length measurements less than a meter, and the bathymetric reproducibility was found to scale with the accuracy of GNSS (3–5 cm), although this could be improved to sub-centimeter with the inclusion of one or more co-registered, but unsurveyed, control points. For future applications, we provide guidance on conducting field operations, correcting underwater image color, and optimizing the SfM workflows. We conclude that a GNSS-coupled underwater camera array is a promising technique to map shallow reefs at high accuracy and resolution without ground control.
CNN-Based Vehicle Bottom Face Quadrilateral Detection Using Surveillance Cameras for Intelligent Transportation Systems
Authors: Kim Gahyun , Jung Ho Gi , Suhr Jae Kyu
Published: July 2023

In intelligent transportation systems, it is essential to estimate the vehicle position accurately. To this end, it is preferred to detect vehicles as a bottom face quadrilateral (BFQ) rather than an axis-aligned bounding box. Although there have been some methods for detecting the vehicle BFQ using vehicle-mounted cameras, few studies have been conducted using surveillance cameras. Therefore, this paper conducts a comparative study on various approaches for detecting the vehicle BFQ in surveillance camera environments. Three approaches were selected for comparison, including corner-based, position/size/angle-based, and line-based. For comparison, this paper suggests a way to implement the vehicle BFQ detectors by simply adding extra heads to one of the most widely used real-time object detectors, YOLO. In experiments, it was shown that the vehicle BFQ can be adequately detected by using the suggested implementation, and the three approaches were quantitatively evaluated, compared, and analyzed.
Biomechanical Analysis of Golf Swing Motion Using Hilbert–Huang Transform
Authors: Dong Ran , Ikuno Soichiro
Published: July 2023

In golf swing analysis, high-speed cameras and Trackman devices are traditionally used to collect data about the club, ball, and putt. However, these tools are costly and often inaccessible to golfers. This research proposes an alternative solution, employing an affordable inertial motion capture system to record golf swing movements accurately. The focus is discerning the differences between motions producing straight and slice trajectories. Commonly, the opening motion of the body’s left half and the head-up motion are associated with a slice trajectory. We employ the Hilbert–Huang transform (HHT) to examine these motions in detail to conduct a biomechanical analysis. The gathered data are then processed through HHT, calculating their instantaneous frequency and amplitude. The research found discernible differences between straight and slice trajectories in the golf swing’s moment of impact within the instantaneous frequency domain. An average golfer, a single handicapper, and three beginner golfers were selected as the subjects in this study and analyzed using the proposed method, respectively. For the average golfer, the head and the left leg amplitudes of the swing motions increase at the moment of impact of the swings, resulting in the slice trajectory. These results indicate that an opening of the legs and head-up movements have been detected and extracted as non-linear frequency components, reviewing the biomechanical meaning in slice trajectory motion. For the single handicapper, the hip and left arm joints could be the target joints to detect the biomechanical motion that triggered the slice trajectory. For the beginners, since their golf swing forms were not finalized, the biomechanical motions regarding slice trajectory were different from each swing, indicating that beginner golfers need more practice to fix their golf swing form first. These results revealed that our proposed framework applied to different golf levels and could help golfers to improve their golf swing skills to achieve straight trajectories.
What Drives People’s Willingness to Adopt Autonomous Vehicles? A Review of Internal and External Factors
Authors: Rahman Md. Mokhlesur , Thill Jean-Claude
Published: July 2023

This article presents a state-of-the-art literature review to understand people’s perceptions and opinions of Autonomous Vehicles and the factors that influence their adoption. A strategic literature search was conducted to select articles for this review. Most of the articles were published since 2015 and they used a household questionnaire survey to collect data. Mostly, they used statistical and econometric methods to evaluate the factors that affect people’s intentions to adopt Autonomous Vehicles. The results show that psychological factors often appear as the most important internal factors of people’s willingness to adopt Autonomous Vehicles. Additionally, other internal factors such as the socioeconomic profile of individuals and their household, and knowledge and familiarity with Autonomous Vehicle technologies would affect adoption tendencies. User attributes also indirectly affect adoption of Autonomous Vehicles by influencing the psychological factors of users. We identify several critical external factors such as opportunities (e.g., safety and security, low congestion, energy use) and challenges (e.g., system failures, privacy breaches, and legal issues), while another influential group includes transportation factors (e.g., travel mode, distance, and time), urban form (e.g., urban/rural, density, land use diversity), affinity to new technology, and the institutional regulatory environment. We discuss some recommendations for policy makers, auto industries, and private stakeholders to formulate policies and strategies to increase the market share of Autonomous Vehicles. Finally, we identify some limitations of previous studies and provide a blueprint for future research on Autonomous Vehicle adoption.
Studying Abuse Testing on Lithium-Ion Battery Packaging for Energy Storage Systems
Authors: Gotz Joelton Deonei , Neto João Eustáquio Machado , Galvão José Rodolfo , Marques Taysa Millena Banik , Siqueira Hugo Valadares , Viana Emilson Ribeiro , Marinho Manoel H. N. , Mohamed Mohamed A. , Ilinca Adrian , Corrêa Fernanda Cristina , Borsato Milton
Published: July 2023

Recently, the increased adoption of electric vehicles (EVs) has significantly demanded new energy storage systems (ESS) technologies. In this way, Lithium-ion batteries (LIB) are the mainstream technology for this application. Lithium presents several advantages compared with other chemicals because it can provide delivery energy for a long time, a long lifetime, and high density and capacity. The LIB comprises several cells connected in different configurations, such as parallel, series, or combinations. This variety of designs makes the monitoring control process more complex, complicating diagnosing and prognosis of abuses and failures. To observe these difficulties, this paper presents sixteen experiments of a mini-packing of four cells under the main abuses found in the LIB. The time series data were collected during the abuses and saved in a CSV file. The results indicated that the current, temperature, and voltage should be used to identify the external short-circuit (ESC) failures in the packing of batteries. On the other side, only the voltage signature is able to determine the Over-Charging (OC), and finally, the combination of temperature and voltage should be used to identify and locate the Over-Discharging (OD) failures in different arrangements of packing. This study also provides ways to build mechanisms to protect the cells and avoid loss of performance and safety issues.
Sustainable Assessment Tools for Higher Education Institutions: Developing Two-Hierarchy Tools for China
Authors: Du Yawei , Ye Qing , Liu Hongjiang , Wu Yuting , Wang Fenghua
Published: July 2023

Higher Education Institutions (HEIs) play an increasingly significant role in the practice of sustainability. For HEIs in their early stages of sustainability, they are still in need of sustainable assessment tools (SATs) that are suitable for their local context and also lead international sustainable development. The purpose of this paper is to develop a two-hierarchy sustainability assessment tool (THSus) for Chinese higher education institutions, including a quick analysis tool (QAT) and an in-depth benchmarking tool (IBT). The QAT provided a general overview of campus sustainability for HEIs to initiate initial actions and screen cases for the IBT. The IBT then provides more targeted analysis to plan long-term strategic changes. Based on the analysis of HEI cases, a 34-person Chinese research team was enlisted to discuss and select characteristics to formulate THSus. Indicators and weightings were developed according to the tool’s purpose and applied to 15 cases to test its effectiveness. Results showed that THSus is suitable for systematically analyzing campus issues, particularly in research areas. It offers a regional solution for Chinese campuses that is adaptable and considers the comprehensive core of sustainability.
Energy Audit as an Instrument to Tackle Internal Barriers to Energy Efficiency: Lessons from Moroccan Industrial Firms
Authors: Bensouda Mehdi , Benali Mimoun , Moufdi Ghada , Idrissi Taoufik El Bouzekri El , Bouhadi Abdelhamid El
Published: July 2023

Due to climate change, firms are encouraged to introduce various measures to enhance both their competitiveness and sustainability, particularly energy efficiency measures (EEMs). Energy efficiency is particularly important in energy-intensive sectors such as the industrial sector. However, EEMs within industrial firms are hindered by several internal barriers such as competing interests within firms, lack of information regarding energy efficiency opportunities, and low technical competence. In this regard, energy audits aim to improve energy efficiency in facilities and to tackle internal barriers to energy efficiency. We developed a model that seeks to investigate the significance of energy audits in the implementation of EEMs and to reduce the intensity of internal barriers to energy efficiency. Our research model was empirically tested via data collected from a survey conducted with 193 industrial firms in the Kingdom of Morocco. Results show that competing interests, lack of information, and low technical competence hinder the adoption of EEMs within industrial firms, which aligns with findings from previous studies. In addition, our findings indicate that energy audits enhance EEMs and mitigate the negative effect of lack of information and low technical competence on the adoption of EEMs, which is consistent with findings from prior studies. However, our results demonstrate that energy audits do not attenuate the negative effect of competing interests on EEMs; this contrasts with findings from several previous studies. Therefore, our study builds upon prior research and contributes new insights regarding the importance of energy audits in tackling internal barriers to energy efficiency.
Sustainable Performance Assessment towards Sustainable Consumption and Production: Evidence from the Indian Dairy Industry
Authors: Kumar Mukesh , Choubey Vikas Kumar
Published: July 2023

The current global economic status quo is widely seen as unsustainable in the food sector. The field of sustainability science is still rather fragmented, covering a wide range of techniques and issues, despite the large number of publications in this area. Due to population growth, the food supply chain (FSC) and farmers have to produce more food. The UN estimates that one-third of edible food is wasted, producing greenhouse gases. A balance must be struck between company operations and social, environmental, and economic activities for sustainable development of the FSC. To assist FSC organizations in managing sustainable advancement, this study created a methodology for the assessment of sustainable performance. We provide a sustainable assessment system using a fuzzy analytic hierarchy process, fuzzy VIKOR, and fuzzy TOPSIS. Our research framework evaluated the sustainability of three cooperative-society-run Indian dairy firms. Our study gives environmental criteria the highest weight (0.33) and social criteria the lowest (0.16), with economic reasons (0.306) and business operations (0.204) falling in the middle. Supply chain costs, on average, are given the highest weight, and capacity utilization, the lowest weight. Three dairy industries are ranked (DPI3, DPI1, and DPI2) based on sustainable performance. By modifying the maximum set utility value and validating VIKOR results with TOPSIS, we have checked the robustness of this performance assessment tool. This research aids dairy businesses in achieving several Sustainable Development Goals, including sustainable production and consumption, through the regular assessment of their sustainable performance.