bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of filgotinib on pain control in the phase 3 FINCH studies
Authors: Taylor Peter C , Kavanaugh Arthur , Nash Peter , Pope Janet , Pongratz Georg , Fautrel Bruno , Alten Rieke , Hasegawa Ken , Rao Shangbang , de Vries Dick , Stiers Pieter-Jan , Watson Chris , Westhovens Rene
Published: March 2024

Objective

This post hoc analysis of the FINCH 1–3 (NCT02889796,NCT02873936andNCT02886728) studies assessed specific effects of filgotinib on pain control and their relationship with other aspects of efficacy in patients with rheumatoid arthritis (RA).

Methods

Assessments included: residual pain responses of ≤10 and ≤20 mm on a 100 mm visual analogue scale (VAS); the proportion of patients who achieved VAS pain responses in addition to remission or low disease activity by Disease Activity Score-28 with C-reactive protein (DAS28-CRP) or Clinical Disease Activity Index (CDAI) criteria.

Results

Across studies, filgotinib reduced pain from week 2, with responses sustained throughout the studies. In FINCH 1, at week 24, 35.8%, 25.0%, 24.6% and 11.6% of patients in the filgotinib 200 mg, filgotinib 100 mg, adalimumab and placebo arms (each plus methotrexate) achieved VAS pain ≤20 mm in addition to DAS28-CRP remission; 26.3%, 17.9%, 17.2% and 7.6% achieved VAS pain ≤10 mm in addition to DAS28-CRP remission. A similar pattern was seen for CDAI remission. Time during which VAS pain was ≤10 or ≤20 mm was longest with filgotinib 200 mg and comparable between adalimumab and filgotinib 100 mg. Similar findings were reported for filgotinib in FINCH 2 and 3.

Conclusion

In all RA populations studied, pain improvements occurred from week 2 and were sustained over time. In FINCH 1, filgotinib 100 mg provided similar pain amelioration to adalimumab, whereas filgotinib 200 mg resulted in greater pain improvement and higher proportion of patients with residual pain ≤10 or ≤20 mm and meeting DAS28-CRP remission criteria.
DFT computation of the electron spectra of thiophene
Authors: Chong Delano P.
Published: March 2024

Recent experiments on thiophene using synchrotron radiation stimulated the present density functional theory (DFT) study of the various types of electron spectroscopy using the DFT methods we developed in our laboratory. Besides the confirmation of the experimental interpretations, the results of the present study strongly validate the methods used for the various types of electron spectroscopy. The average absolute deviations of the DFT results for thiophene from experiment are 0.22 eV for vertical ionization energies of outer valence electrons, 0.10 eV for carbon 1s binding energies, 0.19 eV for vertical valence excitation energies, and 0.18 eV for X-ray absorption energies. The calculated carbon 1s binding energies for bithiophene and terthiophene are also within 0.1 eV of synchrotron experiment. We conclude that workers using synchrotron radiation to study electronic processes of gas-phase molecules can apply our DFT methods for the interpretation of their experimental results.
Moduli space of logarithmic states in critical massive gravities
Authors: Mvondo-She Yannick
Published: March 2024

We take new algebraic and geometric perspectives on the combinatorial results recently obtained on the partition functions of critical massive gravities conjectured to be dual to Logarithmic CFTs through the AdS$$_3$$

3

/LCFT$$_2$$

2

correspondence. We show that the partition functions of logarithmic states can be expressed in terms of Schur polynomials. Subsequently, we show that the moduli space of the logarithmic states is the symmetric product $$S^n\left( {\mathbb {C}}^2 \right) $$

S
n

C

2

. As the quotient of an affine space by the symmetric group, this orbifold space is shown to be described by Hilbert series that have palindromic numerators. The palindromic properties of the Hilbert series indicate that the orbifolds are Calabi-Yau, and allow for a new interpretation of the logarithmic state spaces in critical massive gravities as Calabi-Yau singular spaces.
Coherent interface between optical and microwave photons on an integrated superconducting atom chip
Authors: Petrosyan David , Fortágh József , Kurizki Gershon
Published: March 2024

Sub-wavelength arrays of atoms exhibit remarkable optical properties, analogous to those of phased array antennas, such as collimated directional emission or nearly perfect reflection of light near the collective resonance frequency. We propose to use a single-sheet sub-wavelength array of atoms as a switchable mirror to achieve a coherent interface between propagating optical photons and microwave photons in a superconducting coplanar waveguide resonator. In the proposed setup, the atomic array is located near the surface of the integrated superconducting chip containing the microwave cavity and optical waveguide. A driving laser couples the excited atomic state to Rydberg states with strong microwave transition. Then the presence or absence of a microwave photon in the superconducting cavity makes the atomic array transparent or reflective to the incoming optical pulses of proper frequency and finite bandwidth.
Automorphism and cohomology II: Complete intersections
Authors: Chen Xi , Pan Xuanyu , Zhang Dingxin
Published: March 2024

We prove that the automorphism group of a general complete intersection [Formula: see text] in [Formula: see text] is trivial with a few well-understood exceptions. We also prove that the automorphism group of a complete intersection [Formula: see text] acts on the cohomology of [Formula: see text] faithfully with a few well-understood exceptions.
Quantifying coherence via the generalized Wigner–Yanase–Dyson skew information
Authors: Fan Y. J. , Guo X. , Guo Z. H. , Zhang M.
Published: March 2024

Quantum coherence is an important feature that distinguishes quantum mechanics from classical physics. In this paper, we study the coherence of a quantum state with respect to a quantum channel, and introduce a coherence measure in terms of the generalized Wigner–Yanase–Dyson skew information. The basic properties and operational significance of the measure are expounded in detail, which shows that it is indeed a veritable quantity and satisfies many desirable conditions intuitively required for the coherence measures. We illustrate the significance of characterizing channels from the coherence perspective through some examples. Finally, we consider the average coherence of a state based on the generalized Wigner–Yanase–Dyson skew information with respect to any complete mutually unbiased bases in prime power dimensional systems, as well as with respect to all orthonormal bases, and show that these two averages are equivalent since they both can be seen as the coherence of the quantum state with respect to the depolarizing quantum channel.
A Fuzzy Neural Network-Based Intelligent Warning Method for Financial Risk of Enterprises
Authors: Yao Qing , Mao Chunmei , Guo Yundong
Published: March 2024

The fast warning for financial risk of enterprises has always been a realistic demand for their managers. Currently, this mainly relies on expert experience to make comprehensive analysis from massive business data. Benefitting from the strong computational performance of deep learning, this paper proposes a fuzzy neural network (FNN)-based intelligent warning method for financial risk of enterprises. An improved FNN structure with time-varying coefficients and time-varying time lags is established to extract features of enterprises from complex financial context. The algorithm of fuzzy C-means and fuzzy clustering based on sample data are studied. In this paper, the fuzzy C-means algorithm is used to cluster the samples, the input sample set is preprocessed, a new set of learning samples is formed, and then the neural network is trained. The enterprise financial risk sample and its modular FNN model are established, and the evaluation of the enterprise financial risk sample is simulated. Then, a decision part is added following the FNN part to output the warning results. After that, we have also conducted a case study as simulation experiments to evaluate the proposed technical framework. The obtained results show that it can perform well in the fast warning of financial risk for enterprises.
Bifurcation Analysis of a Predator–Prey Model with Alternative Prey and Prey Refuges
Authors: Cui Wenzhe , Zhao Yulin
Published: March 2024

In this paper, we study the codimensions of Hopf bifurcation and Bogdanov–Takens bifurcation of a predator–prey model with alternative prey and prey refuges, which was proposed by Chen et al. [ 2023 ]. The results show that the predator–prey model can undergo a supercritical Hopf bifurcation or a Bogdanov–Takens bifurcation of codimension two under certain parameter conditions. It means that there are some predator–prey models with an alternative prey and prey refuges which have a limit cycle or a homoclinic loop. Moreover, it is also shown that the codimension of Hopf bifurcation is at most one and codimension of Bogdanov–Takens bifurcation is at most two.
Manin triples associated to n-Lie bialgebras
Authors: Chen Ying , Kang Chuangchuang , Lü Jiafeng , Yu Shizhuo
Published: March 2024

In this paper, we study the Manin triples associated to [Formula: see text]-Lie bialgebras. We introduce the concept of operad matrices for [Formula: see text]-Lie bialgebras. In particular, by studying a special case of operad matrices, it leads to the notion of local cocycle [Formula: see text]-Lie bialgebras. Furthermore, we establish a one-to-one correspondence between the double of [Formula: see text]-Lie bialgebras and Manin triples of [Formula: see text]-Lie algebras.
Parameters Influencing the Fatigue Behavior of Ti6Al4V
Authors: Arcieri Emanuele Vincenzo
Published: March 2024

The fatigue strength of components is affected by loading and environmental conditions, their geometry, the material and the manufacturing process adopted for their production. As a consequence of local stress concentrations, fatigue cracks can propagate to failure from the defects created by the manufacturing processes or introduced during the service life, as occurs in impact-damage. Ti6Al4V titanium alloy is commonly used in the aeronautical sector and other engineering applications due to its high specific strength. The study of the fatigue behavior of Ti6Al4V is therefore critical for designing reliable and durable structures. The work reports a synthesis of the results present in the literature for the fatigue behavior of Ti6Al4V in inert and aggressive environments, in the presence of a deposited coating, in the case of impact-damage, when components are produced by additive manufacturing and in the absence of solution treatment and over-aging.
Scattered Acoustic Field Above a Rigid Rectangular Cuboid Shape in a Rigid Plane
Authors: Khanfir A. , Ducourneau J. , Faiz A. , Nasri R. , Chevret P.
Published: March 2024

A model is presented for the scattered acoustic field above a bulky rigid cuboid shape in a rigid plane insonified by an acoustic field. The Kobayashi Potential method and the image sources method were used in order to derive the scattered acoustic field in a modal form. The incident source was then decomposed into plane waves. The total scattered field was determined by summing all the elementary scattered fields. This model was compared to finite element modeling and experimental results for three bulky cuboid shapes in an infinite rigid screen and a rectangular corner insonified by a spherical source. A good agreement between numerical and experimental results was obtained supporting the validity of the model.
A Small Clue Made of Fragmented Pieces
Authors: Lee Minhyung , Min Jinyoung , Lee Junyeong , Kwak Chanhee , Choi Hanbyeol Stella
Published: March 2024

The effect of online comment history disclosure on digital citizenship.
Answers Begin to Surface to Deep Earth Puzzles
Authors: Edwards Chris
Published: March 2024

Evidence from high orbit is helping to shape understanding of the churning processes that shape oceans and continents.
Stabilization versus Penetration Dynamics Induced by Localized Concentration Polarization in Solid Polymer Electrolytes
Authors: Lee Youngju , Bai Peng
Published: March 2024

While the onset of dendrites found inside solid polymer electrolytes was typically analyzed by the dilute solution theory, nonideal behaviors such as dendrites at underlimiting current densities were often reported. Here, we consider two critical factors that were often neglected in existing studies, the severe heterogeneous current distribution and the dynamic change of modulus during the polarization process. Polymers with different dynamic mechanical properties were assessed, exploiting the recently discovered mechanism of phase transformation inside low-salt-concentration polymers. Analyses of the operando images revealed two characteristic points on the potential curve, the local and total concentration depletion which each corresponded to the starting and stopping point of dendrites. We further assess these dynamics at different degrees of heterogeneity controlled by different electrode sizes. The penetration dynamics and Sand’s time scaling exponent were heavily affected by both the initial concentration and the electrode size, which stress the significance of interfacial dynamic heterogeneity in working batteries.
Review—Recent Progress on MOFs-based Electrode Materials for Supercapacitor
Authors: Asghar Ali , Ghaly Waleed A. , Awaji Majed Y. , Hakami Othman , Alamier Waleed M. , Ali Syed Kashif , Almashnowi Majed Y. A. , Al-Harthi Enaam A. , Rashid Muhammad Shahid , Imran Mohd
Published: March 2024

Supercapacitors (SCs) are gaining popularity as energy storage devices (ESDs), and their electrode materials strongly influence their performance. There is no doubt that SCs are capable and reliable ESDs for producing high power even when they operate at low energy levels. However, highly efficient electrode materials are still required to make the SC an effective choice for ESD. The surface modification of the electrode materials can improve the power and energy density of materials, which is beneficial for enhancing the electrochemical performance of the SC. During the past few years, more research has been reported to develop new electrode materials for improving SCs’ energy density, charge retention, specific capacitance, stability, and rate performance. This review focuses on the execution of progressive organic-based electrode materials called metal-organic frameworks (MOFs) in the SC. The main purpose of this review is to explain the MOFs-based electrode materials and their progress in the field of SC. MOFs are advanced materials for supercapacitors because they allow for various features, including dimensions. They offer high stability, high capacity, adjustable pore size, greater aspect ratios, larger surface areas, and stronger bonding between metal and organic linkers than the previously reported electrode materials (Metal oxide, sulfide, phosphate, etc). These properties of MOFs-based electrode materials make them promising for electrochemical energy storage applications. Finally, the challenges and perspectives of MOFs-based electrode materials are discussed.
Iron/Iron(III) Oxide Decorated on Electrochemically Reduced Graphene Oxide: a Novel One-Step Electrosynthesis and a Fabrication of an Electrochemical Ascorbic Acid Sensor
Authors: Tran Luyen Thi , Tran Hoang Vinh , Huynh Chinh Dang , Sai Cong Doanh , Thi Duong Ngan
Published: March 2024

Considering on required detection time and sensitivity, electrochemical method is an excellent candidate for ascorbic acid (AA) sensing. We propose using the synergistic effects of iron(0)/iron(III) oxide decorated on the electrochemically reduced graphene oxide (ERGO/Fe-Fe2O3) modified Pt microelectrode as an electrochemical AA sensor using cyclic voltammetry (CV) technique. Herein, ERGO/Fe-Fe2O3 was directly fabricated on the Pt microelectrode using a novel one-step electrosynthesis. Fe-Fe2O3 acts as an oxidized-nanozyme with works as redox centers on the electrode for oxidation of AA. Fe-Fe2O3 nanozymes are immobilized on electrochemically reduced graphene oxide (ERGO), which supports a large electroactive and excellent electrically conductive surface for electron-transfer during electrochemical oxidation of AA. The developed electrochemical sensor allowed for sensing AA in medical samples with high sensitivity in concentration range from 0.05 to 10.00 mM and a limit of detection (LOD) of 5.93 μM.
Specific Removal and Recovery of Bromide Ions: The Search for Stable Electrodes and Operation Modes
Authors: Cohen Izaak , Shapira Barak , Shopin Alexey , Elias Yuval , Avraham Eran , Aurbach Doron
Published: March 2024

In previous work, we introduced an elegant approach for bromide recovery from water by the introduction of a hybrid physical adsorption and capacitive deionization processes for selective removal and recovery of boron from water. In this paper, we show that the harsh environment of water contaminated with bromine-moieties adversely affects the longevity of relevant electrodes, with close to 100 consecutive work hours of bromides removal without noticeable degradation. To extend the lifespan of electrodes, we used an asymmetric CDI cell with a 1:5 positive/negative electrodes ratio in which a polarity switch between electrodes is applied every six adsorption-desorption cycles in a way that in each adsorption-desorption cycle, a different electrode of the six electrodes, functions as the positive electrode. We deduce that the polarity switch reduces oxidation and subsequent degradation of the positive electrodes, resulting in an extended lifecycle. After examining nine different carbonaceous materials, carbon cloth was chosen to be incorporated in the bromide- recovery cells because of its favorable kinetics and its physical and mechanical properties. We show that with a combination between endurance of the electrodes and asymmetric mode of operation, it is possible to overcome the main barrier that holds the technology from being practical.
Preliminary Experimental Study of Herbal Electrolyte for Future Green Battery
Authors: Ganti Krishna Bhargav , Singh Ajay Kumar , Joshi Jetendra
Published: March 2024

Batteries are turned into one of the widely used energy source in our day-to day life which relies on the electrochemical dynamics and interaction among the electrolyte and electrodes. An electrolyte is important component of battery to decide the transfers ions back and forth between two electrodes which results electrical energy generation. However, electrolytes used in the conventional batteries are very hazardous due to release of toxic chemicals in the environment which affects the growth of plants and aquatic life. Therefore, it becomes clear that the chemical electrolyte system could no longer be required in future and design and characterization of alternative electrolyte is very important. The new electrolyte concepts hold the important metrices of any battery, higher safety, lower cost, and better cycle time. In the present paper we have carried out the preliminary investigation of the performance of Herbal electrolyte, which is cheap, non-flammable and insensitive to temperature. The main constituents of the proposed electrolyte are aloe vera gel, garlic cloves and Indian Jadi Buti which makes the electrolyte eco-friendly and non-toxic and does not cause any damage to environment when it disposed of.
Research on the Load Bearing and Impact Resistance of a Novel Structure Exhibiting Both Positive and Negative Poisson’s Ratios
Authors: Zhang Xidong , Cui Hongyu , Hu Haoming , Yin Xiaokai , Xu Huanqiu
Published: March 2024

A ship equipment pedestal is a structure that connects power equipment to a hull. It must have a high load‐bearing capacity and the ability to withstand large impact loads. In this paper, a novel structure with a positive‐negative Poisson’s ratio is proposed. The deformation mechanism and mode of this structure under quasistatic compression loading are analysed via numerical simulation. Based on this new structure, a multicellular pedestal is designed, and its bearing capacity and impact resistance are analysed. The structural parameters of the pedestal are optimized. An experiment is conducted to evaluate the impact resistance of the pedestal model, which confirms that the proposed multicellular pedestal exhibits excellent impact resistance.
Perspectives and Experiences of Healthcare Professionals Involved in a Community Nurse-Delivered Shared Care Model Intervention Designed to Support Outpatients Receiving Chemotherapy: A Qualitative Study Using Interviews
Authors: Kim Bora , Boustany Chantale , Acret Louise , McLeod Jodi , Cook Natalie , McKenzie Heather , Hayes Lillian , Fethney Judith , Simpson Judy M. , Willcock Simon , White Kate
Published: March 2024

Background. Chemotherapy can cause a range of side effects including nausea, vomiting, diarrhea, and infection, which can have a significant impact on an individual’s quality of life. Survival outcomes can be impacted when side effects are poorly managed, leading to failure to complete the defined dose of treatment. Objective. This study presents clinicians’ experiences with a shared care model involving home-based community nurse (CN) support to improve side-effect management of individuals receiving chemotherapy as an outpatient. Methods. A qualitative study was conducted with CNs, cancer nurses, medical oncologists, and a general practitioner involved in the CN intervention delivered as part of a randomized controlled trial (RCT) aimed at reducing unplanned presentations to hospital of cancer patients receiving outpatient chemotherapy. Semistructured individual and focus group interviews were conducted. Key themes were identified using thematic analysis. Findings. Twenty-three healthcare professionals were interviewed. Three themes were identified: (1) being able to enhance patient-centered care and clinical practice during chemotherapy; (2) importance of effective communication and collaborative relationships between different care settings; and (3) ways to adapt the intervention for implementation in routine clinical practice. Participants reported that it was feasible for CNs to care for this patient group, and their home visits enabled preemptive symptom management. Suggestions to improve and modify the intervention to implement this care model within existing clinical care included a flexible approach, such as a blended delivery with face-to-face visits and telephone calls; a risk- or needs-based approach to prioritize patient groups more likely to benefit from the intervention; and sharing of electronic medical records for more effective collaboration and communication. Conclusions. A CN-delivered shared care model provided a feasible approach to the provision of individualized support for outpatients receiving chemotherapy. This study suggests ways to adapt this care model into existing clinical workflow and structures. This trial is registered with ACTRN12614001113640.
The Efficacy of On-Site Integration Screening and Microelimination Programs for Chronic Hepatitis C in a Detection Center: A Comparison of the Treatment Outcomes and Characteristics of Incarcerated Patients and Outpatients
Authors: Chang Hsuan-Yuan , Wang Su-Hung , Kuo Hsing-Tao , Sheu Ming-Jen , Feng I-Che , Ho Chung-Han , Chen Jui-Yi , Sun Chi-Shu , Chen Chi-Hsing , Lin Cheng-Yi , Yang Chun-Chi
Published: March 2024

We aimed to analyze the different patient characteristics and treatment outcomes (such as sustained viral response, SVR) between incarcerated patients with chronic hepatitis C (CHC) and those with CHC from the outpatient department through an on-site integrated screening and microelimination program in a detection center. In this retrospective study, which ran from May 2021 to April 2022, we included 32 consenting male prisoners aged at least 20 years who were willing to participate in the study. Members of the control group (who received DAAs in an outpatient setting) were selected from the treated CHC patient databank of individuals who received DAA regimens at Chi Mei Hospital between January 2021 and December 2022. The patients in the two groups did not differ significantly in terms of age, FIB-4 score, HCV RNA, HBV coinfection, hemogram findings, coagulation profiles, and renal function tests. However, the patients in the incarcerated group had a significantly different genotype distribution compared to the control group, significantly lower liver enzyme levels, and higher albumin and bilirubin levels compared to those in the control group. The rate of SVR to DAA treatment obtained among incarcerated patients did not differ significantly from that obtained among patients in the control group. Loss to follow-up (for several reasons) is a major reason for treatment discontinuation among these patients.
Increased 18F‐THK5351 Uptake at Bilateral Primary Motor Cortex in Patients with Progressive Pseudobulbar Palsy
Authors: Takahashi Kensuke , Kurihara Masanori , Ishibashi Kenji , Komori Yuta , Goto Ryoji , Higashihara Mana , Kameyama Masashi , Hirano Hirohiko , Maeda Meiko Hashimoto , Watanabe Rie , Ishii Kenji , Iwata Atsushi
Published: March 2024

Background. Although patients can present with progressive pseudobulbar palsy due to neurodegenerative diseases, detection of the precise location of radiological abnormalities can be difficult. 18F‐THK5351 was initially developed as a tau positron emission tomography (PET) tracer. Later, it was found to sensitively detect astrogliosis associated with neurodegeneration. Therefore, it has been used in diagnosis of various diseases. However, its utility in progressive pseudobulbar palsy was unknown. Methods. 18F‐THK5351 PET results of two patients presenting with progressive pseudobulbar palsy are reported. Results. Patient 1 was a 77‐year‐old man with a two‐year history, and Patient 2 was a 61‐year‐old woman with a 1‐year history. Both patients presented with gradually progressive spastic dysarthria, suggesting pseudobulbar palsy without clinical lower motor neuron signs. Facial asymmetry was detected in both patients, while left‐dominant pyramidal signs in the extremities were detected only in Patient 2. Brain magnetic resonance imaging did not show signal abnormality explaining pseudobulbar palsy. However, 18F‐THK5351 PET clearly visualized bilateral increased uptake in limited areas of the posterior portion of the precentral gyrus, corresponding to the midportion of the primary motor cortex. Laterality of increased 18F‐THK5351 uptake corresponded to the symptom laterality and was higher on the left and right side in patients 1 and 2, respectively. After one year, Patient 1 was unable to vocalize and could only produce grunts; concomitant apraxia of speech was suspected. Conclusions. 18F‐THK5351 PET is a useful method to detect bilateral primary motor cortex involvement in patients presenting with progressive pseudobulbar palsy, likely by imaging astrogliosis.
Leveraging Supervisor Knowledge Sharing Behavior and Organizational Absorptive Capacity on Nurses’ Creativity
Authors: Abdelwahab Ibrahim El-Sayed Ahmed , Ahmed Mohamed Elbassal Nariman , Ahmed Alsenany Samira , Mohammed Farghaly Abdelaliem Sally
Published: March 2024

Background. Nurses’ creativity is an imperative necessity for healthcare organizations to grow. The creative abilities of nurses are affected by many factors; some of these factors are stimulants and some of these are inhibitors. Supervisors’ knowledge sharing behavior and the capacity to absorb new knowledge and technologies are important factors in the recent era that delineate the creativity of nurses. Aim of the Study. Assess the effect of supervisor knowledge sharing behavior and organizational absorptive capacity on nurses' creativity. Method. Cross-sectional multicenter descriptive correlational exploratory research design was used to conduct the study. Data were collected conveniently from 700 nurses recruited from five large hospitals at Alexandria, Egypt, using three self-administered printed questionnaires. Findings were investigated via descriptive and inferential statistics as well as structured equation modeling. Results. Nurses’ creativity was positively associated with supervisor knowledge sharing behavior and organizational absorptive behavior (r = 0.619, p value <0.001, and r = 0.545, p value <0.001, respectively). Supervisor knowledge sharing behavior accounted for 87% of variance in nurses’ creativity, while organizational absorptive capacity accounted for 55% of variance in nurses’ creativity. Conclusion. Supervisors’ knowledge sharing behavior and absorptive capacity of organization are powerful significant stimulants for nurses’ creativity. Implications to Nursing Management. Hospital directors, managers, and nursing leaders should cultivate knowledge sharing behavior in healthcare settings by establishing a reward and incentive system for healthcare workers who share their knowledge with their colleagues for mutual benefit and organizational development.
Caffeic Acid Dimethyl Ether Ameliorates Excessive Glucose and Lipid-Induced Insulin Secretion Dysfunction in Pancreatic Beta-Cells through the miR-378b–PI3K–AKT Pathway
Authors: Zhou Ermei , Liang Yanqing , Chen Qi , Bi Jianghui , Chen Junjie , Li Yongwen , Li Li
Published: March 2024

An important factor in the progression of type 2 diabetes mellitus is the malfunctioning insulin production by β-cells in the pancreas. Caffeic acid dimethyl ether (CADE) reduces resistance to insulin in alcoholic fatty liver disease, but both the therapeutic effects of CADE on excessive glucose and lipid-induced insulin secretion disorders and the underlying mechanisms are unknown. The aim of this research was to (i) explore how CADE impacts insulin production issues caused by a surplus of glucose and lipids β-cells and (ii) elucidate the underlying mechanism. The results of our research demonstrated that insulin production was reduced in the pancreas of mice given a high-fat -diet and streptozotocin, as well as in human 1.1B4 pancreatic β-cells treated with high -glucose and high -fat, with increased activity of miR-378b and decreased expression levels of p110α, p-AKT1/2, insulin receptor, p-FoxO1, and PDX-1. However, treatment with CADE ameliorated the insulin secretion impairment by decreasing the miR-378b level and reversing the inhibitory effects on the aforementioned factors. Overexpression of miR-378b exacerbated the insulin secretion disorder and inhibited the PI3K-AKT signaling pathway, whereas miR-378b deficiency relieved the insulin secretion disorder, activating the PI3K-AKT pathway. In addition, CADE ameliorated the impairment of insulin secretion and reversed the miR-378b overexpression-induced PI3K-AKT pathway inhibition. In conclusion, our study demonstrates that CADE ameliorated insulin secretion dysfunction induced by excess lipid and glucose in β-cells by downregulating miR-378b expression, thus promoting PI3K-AKT activation.
Supplementary Figure 4 from Dabrafenib Alters MDSC Differentiation and Function by Activation of GCN2
Authors: Ciudad M. Teresa , Quevedo Rene , Lamorte Sara , Jin Robbie , Nzirorera Nadine , Koritzinsky Marianne , McGaha Tracy L.
Published: March 2024

Supplementary Figure 4
Supplementary Figure 2 from Dabrafenib Alters MDSC Differentiation and Function by Activation of GCN2
Authors: Ciudad M. Teresa , Quevedo Rene , Lamorte Sara , Jin Robbie , Nzirorera Nadine , Koritzinsky Marianne , McGaha Tracy L.
Published: March 2024

Supplementary Figure 2
Supplementary Figure 1 from Dabrafenib Alters MDSC Differentiation and Function by Activation of GCN2
Authors: Ciudad M. Teresa , Quevedo Rene , Lamorte Sara , Jin Robbie , Nzirorera Nadine , Koritzinsky Marianne , McGaha Tracy L.
Published: March 2024

Supplementary Figure 1
Repair of a Large Nasal Ala and Medial Cheek Defect: Case Report
Authors: Myers Hannah E. , Kessler Ashley A. , Roberts Michael , Buckley Christopher
Published: March 2024

Introduction: Mohs micrographic surgery is a complex but essential aspect of functional and cosmetic skin cancer removal. It allows for skin cancers to be removed from cosmetically challenging areas in the most efficient and effective possible method; however, closure of these lesions can be difficult. Case: An 80-year-old male presented for Mohs surgery of a basal cell carcinoma on the right nasal sidewall that measured 3.4 cm. The patient underwent seven stages of Mohs surgery, and the final defect measured 6.5 cm × 5.5 cm, resulting in a large area for closure with multiple cosmetic and functional units affected. Discussion: This case discusses options for complex closure of large defects on the nose and the reasoning behind the final choice in closure.
The Intake of Cruciferous Vegetables and the Risk of Ovarian Cancer: A Systematic Review and Dose-Response Meta-Analysis
Authors: Li Meiqiong , Long Jiaye , Yang Miyang , Pang Yingrong , Chen Baoxiang , Li Hong
Published: March 2024

Introduction: The link between cruciferous vegetables (CVs) and ovarian cancer (OC) is still uncertain. This meta-analysis is intended to investigate the association between CV consumption and the risk of OC, as well as to conduct a dose-response analysis to determine the degree of correlation between them. Methods: We systematically searched PubMed, Web of Science, Embase, and Cochrane Library databases between database creation and October 2023. The present meta-analysis has been duly registered and assigned the registration number CRD42023470299. This study followed the PRISMA guidelines. The statistical analysis was performed using Stata 14.0 software. Results: There were a total of 7 cohort studies and 7 case-control studies with 7,269 cases and 742,952 subjects. The combined relative risk (RR) of the highest intake of CVs was 0.90 (95% confidence intervals [CIs]: 0.84–0.96; I2 = 54.7%; p = 0.007) compared to the lowest intake of CVs. The odds ratio (OR) was 0.97 (95% CIs: 0.86–1.08; p = 0.192) for cohort studies, and the RR was 0.79 (95% CIs: 0.67–0.91; p = 0.167) for case-control studies. The intake of CVs and the risk of OC were linearly correlated. Adding 15 g of CVs to the diet each day decreased the likelihood of developing OC by almost 4% (RR = 0.963, 95% CIs: 0.905–1.025; p = 0.235). Conclusions: Consumption of CVs may be linked to a lower risk of OC.
Recurrence After Atrial Fibrillation Ablation and Investigational Biomarkers of Cardiac Remodeling
Authors: El‐Harasis Majd A. , Quintana Joseph A. , Martinez‐Parachini J. Roberto , Jackson Gregory G. , Varghese Bibin T. , Yoneda Zachary T. , Murphy Brittany S. , Crawford Diane M. , Tomasek Kelsey , Su Yan Ru , Wells Quinn S. , Roden Dan M. , Michaud Gregory F. , Saavedra Pablo , Estrada Juan Carlos , Richardson Travis D. , Kanagasundram Arvindh N. , Shen Sharon T. , Montgomery Jay A. , Ellis Christopher R. , Crossley George H. , Eberl Magdalena , Gillet Ludovic , Ziegler Andre , Shoemaker M. Benjamin
Published: March 2024

Background

Recurrence after atrial fibrillation (AF) ablation remains common. We evaluated the association between recurrence and levels of biomarkers of cardiac remodeling, and their ability to improve recurrence prediction when added to a clinical prediction model.

Methods and Results

Blood samples collected before de novo catheter ablation were analyzed. Levels of bone morphogenetic protein‐10, angiopoietin‐2, fibroblast growth factor‐23, insulin‐like growth factor‐binding protein‐7, myosin‐binding protein C3, growth differentiation factor‐15, interleukin‐6, N‐terminal pro‐brain natriuretic peptide, and high‐sensitivity troponin T were measured. Recurrence was defined as ≥30 seconds of an atrial arrhythmia 3 to 12 months postablation. Multivariable logistic regression was performed using biomarker levels along with clinical covariates: APPLE score (Age >65 years, Persistent AF, imPaired eGFR [<60 ml/min/1.73m
2
], LA diameter ≥43 mm, EF <50%; which includes age, left atrial diameter, left ventricular ejection fraction, persistent atrial fibrillation, and estimated glomerular filtration rate), preablation rhythm, sex, height, body mass index, presence of an implanted continuous monitor, year of ablation, and additional linear ablation. A total of 1873 participants were included. A multivariable logistic regression showed an association between recurrence and levels of angiopoietin‐2 (odds ratio, 1.08 [95% CI, 1.02–1.15],
P
=0.007) and interleukin‐6 (odds ratio, 1.02 [95% CI, 1.003–1.03];
P
=0.02). The area under the receiver operating characteristic curve of a model that only contained clinical predictors was 0.711. The addition of any of the 9 studied biomarkers to the predictive model did not result in a statistically significant improvement in the area under the receiver operating characteristic curve.

Conclusions

Higher angiopoietin‐2 and interleukin‐6 levels were associated with recurrence after atrial fibrillation ablation in multivariable modeling. However, the addition of biomarkers to a clinical prediction model did not significantly improve recurrence prediction.
Prognostic Utility of Society for Cardiovascular Angiography and Interventions Shock Stage Approach for Classifying Cardiogenic Shock Severity in Takotsubo Syndrome
Authors: Camblor‐Blasco Andrea , Nuñez‐Gil Ivan J. , Duran Cambra Albert , Almendro‐Delia Manuel , Ródenas‐Alesina Eduard , Fernández‐Cordon Clara , Vedia Oscar , Corbí‐Pascual Miguel , Blanco‐Ponce Emilia , Raposeiras‐Roubin Sergio , Guillén Marzo Marta , Sanchez Grande Flecha Alejandro , Garcia Acuña Jose Maria , Salamanca Jorge , Escudier‐Villa Juan M. , Martin‐Garcia Agustin C. , Tomasino Marco , Vazirani Ravi , Perez‐Castellanos Alberto , Uribarri Aitor
Published: March 2024

Background

Cardiogenic shock (CS) is a significant complication of Takotsubo syndrome (TTS), contributing to heightened mortality and morbidity. Despite this, the Society for Cardiovascular Angiography and Interventions (SCAI) staging system for CS severity lacks validation in patients with TTS and CS. This study aimed to characterize a patient cohort with TTS using the SCAI staging system and assess its utility in cases of TTS complicated by CS.

Methods and Results

From a TTS national registry, 1591 consecutive patients were initially enrolled and stratified into 5 SCAI stages (A through E). Primary outcome was all‐cause in‐hospital mortality; secondary end points were TTS‐related in‐hospital complications and 1‐year all‐cause mortality. After exclusions, the final cohort comprised 1163 patients, mean age 71.0±11.8 years, and 87% were female. Patients were categorized across SCAI shock stages as follows: A 72.1%, B 12.2%, C 11.2%, D 2.7%, and E 1.8%. Significant variations in baseline demographics, comorbidities, clinical presentations, and in‐hospital courses were observed across SCAI shock stages. After multivariable adjustment, each higher SCAI shock stage showed a significant association with increased in‐hospital mortality (adjusted odds ratio: 1.77–29.31) compared with SCAI shock stage A. Higher SCAI shock stages were also associated with increased 1‐year mortality.

Conclusions

In a large multicenter patient cohort with TTS, the functional SCAI shock stage classification effectively stratified mortality risk, revealing a continuum of escalating shock severity with higher stages correlating with increased in‐hospital mortality. This study highlights the applicability and prognostic value of the SCAI staging system in TTS‐related CS.
Rousseau’s Contribution to Public Theology
Authors: Yang Jae
Published: March 2024

This article argues that Jean-Jacques Rousseau can be seen as a public theologian by analyzing two well-known treatises. It draws on the Latin root of the concept of the ‘public’, in order to underscore the anthropology and sociology of public life. The article argues that Rousseau is a public theologian as his public policy of social organization, presupposes anthropological and sociological views of humanity that parallel views found in Christian theology.
A Biblical-Theological Critique of Neo-Liberal and Neo-Conservative Evangelicalism in the Season of Climate Change
Authors: Choi Sungho
Published: March 2024

The purpose of this article is to examine the impact of neo-liberalism and neo-conservatism upon American evangelicalism. It does so in the season of climate change. Given the commitment of neo-liberalism to the sovereignty of individual, the notion of government intervention in implementing climate mitigation policies is perceived as an unacceptable violation of freedom. It sits along the ideological challenge of neo-conservatism. Its emphasis on an ‘enduring-moral order’ has inadvertently culminated in ethnocentric anti-globalism, which theoretically conflicts with neo-liberalism’s ideals. These two worldviews are both to be found in expressions of American evangelicalism, however. What might be a biblical-theological response? The argument draws upon the corporate nature of salvific claims, the early church governance in Luke-Acts and finally the social-gospel movement to challenge the association of evangelicalism with the Republican Party. The significance of this critique is due to the way in which this association lies at the heart of climate scepticism.
International Law and Ocean Nuclear Power Plants in the Arctic
Authors: Leopardi Martin Ratcovich
Published: March 2024

This article addresses the international law of ocean nuclear power plants (ONPPs) with a particular focus on the Arctic. Encompassing norms under the law of the sea, maritime law, environmental law, nuclear energy law and humanitarian law, the article discusses how existing fundamental legal regulations apply to ONPPs in the Arctic. Additionally, the legal role of some relevant institutions, such as the International Atomic Energy Agency, the International Maritime Organization, and the Arctic Council, is considered. While the military nuclearisation of the Arctic has been the subject of much scholarly concern, the civil nuclearisation has not – at least not from an international law perspective. International law provides States with a considerable degree of freedom when it comes to the development and deployment of ONPPs, but there are several challenges and legal gaps, not least regarding special legal regulations for the Arctic.
What Makes Gentrification Wrong? A Place-based Account
Authors: Krishnamurthy Meena , Moore Margaret
Published: March 2024

Through an analysis of the moral relationship between people and place, this paper offers a new view of the wrongful character of gentrification, which is pluralistic, locating the wrong in the non-fulfillment of three place-related rights: rights to a home, rights of residency, and place-based rights to a community. By focusing on the multiple ways that people are connected to place, we offer a more complete and systematic account of place-related rights that is not only able to make sense of people’s lived experiences of the harms of gentrification but is also able to address standard criticisms, which have been made of other key accounts of the wrong of gentrification.
Reframing the Indian Middle Class as a Labour Aristocracy
Authors: Sharma Aryaman
Published: March 2024

Taking from, and critiquing, both the scholarship on the Indian “middle class” as well as the scholarship on the ‘labour aristocracy’, this paper argues for the reformulation of the Indian “middle class” as a labour aristocracy or worker elite. We define the distinctive characteristics that set the Indian worker elite apart from the broader working class and highlight, through the case studies of international migration, patterns in urban living spaces and domestic service employment, the stark differences between the worker elite and the poor working masses in India, and the exploitative relationship that exists between the two. The analysis points to the semi-periphery being the locus of the largest inequalities in the capitalist world-system today, where the bourgeoisie and the worker elite both gain tremendously from the exploitation inherent to capitalism. Resultingly, the task at hand in India and the semi-periphery broadly remains to organize the poor, marginalised working masses.
New findings of Cryptomarasmius (Physalacriaceae, Agaricales) from Jilin Province, China
Authors: LI SIYING , BAU TOLGOR
Published: March 2024

We conducted a field investigation of marasmioid fungi in Jilin Province, China. Based on morphological and phylogenetic studies, seven specimens belonged to Cryptomarasmius (Physalacriaceae) were identified as three species. Phylogenetic analyses of ITS-nrLSU datasets conducted using Maximum Likelihood and Bayesian methods showed that C. changchunensis and C. aucubae are a new species and newly recorded species to China, respectively. Detailed descriptions and illustrations of the two species are provided in this study.
Aspidistra luofushanensis (Asparagaceae), a new species from Guangdong, China
Authors: LIU ZHI-RONG , LIN CHUN-RUI , HUANG XIAO-SA , ZENG YUN-BAO , MENG DE-CHANG , MO FU-YAN
Published: March 2024

Aspidistra luofushanensis, a new species of Asparagaceae from northeast Guangdong, China, is described and illustrated. Morphologically it is similar to A. punctata but can be distinguished by the suberect or slightly inward bending perianth lobes, pollen sacs facing upwards, umbrella-like pistil, upper surface white to light purplish red of sigma with margin lobes revolute. The morphology, pollen morphology and color plates are provided for comparison.
Two new records of Meliolaceous black mildew fungi from India
Authors: NATEKAR PRATIK D. , PATIL ANJALI P. , PATIL CHANDRAHAS R. , BHISE MAHENDRA R. , KAMBHAR SIDANAND V.
Published: March 2024

Two black mildew fungi, Asteridiella leeicola and Meliola holarrhenicola were found on new host plants, Leea indica (Vitaceae) and Holarrhena pubescens (Apocynaceae), respectively. These species have not been reported from India. Therefore, the present report contributes new records for India. Taxonomic observations and microphotographs are provided for easy identification of taxa.
Twenty-one new species of Omaliini from the Papuan Region (Coleoptera: Staphylinidae: Omaliinae), with diagnostic and faunistic notes on some species of the genus Paraphloeostiba Steel, 1960
Authors: SHAVRIN ALEXEY V.
Published: March 2024

New taxonomic, diagnostic and faunistic data for 26 species of Nipponophloeostiba Watanabe, 1962 (one species), Paraphloeostiba Steel, 1960 (23 species) and Xanthonomus Bernhauer, 1926 (two species) of the tribe Omaliini McLeay, 1825 of the Papuan Region (Indonesia (Western New Guinea), Papua New Guinea and Solomon Islands) are provided. Twenty-one new species are described and illustrated: Nipponophloeostiba hornabrooki sp. n., Paraphloeostiba assimile sp. n., P. attenuata sp. n., P. barclayi sp. n., P. betlephila sp. n., P. coprophila sp. n., P. latissima sp. n., P. okapensis sp. n., P. rufula sp. n., P. steeli sp. n., P. telnovi sp. n. and Xanthonomus thayerae sp. n. from Papua New Guinea, P. atramentaria sp. n., P. iriana sp. n., P. margineguttata sp. n., P. pilosa sp. n., P. riedeli sp. n., P. vitiosa sp. n., and X. guineensis sp. n. from Western New Guinea (Indonesia), and P. guadalcanalensis sp. n. and P. penelopeae sp. n. from Solomon Islands. Paraphloeostiba coriacea (Cameron, 1952) and P. rhopalocera (Cameron, 1928) are redescribed and illustrated. The male of P. papuana (Cameron, 1931) and females of P. conjuncta Shavrin, 2023 and P. coriacea are described and illustrated for the first time. Keys for Nipponophloeostiba Watanabe, 1962, Xanthonomus Bernhauer, 1926, and the Papuan species of the genus Paraphloeostiba are provided. Distributional maps of Xanthonomus and Nipponophloeostiba, and P. coriacea, P. gayndahensis (MacLeay, 1873) (for New Guinea) and P. papuana are given. Paraphloeostiba conjuncta, P. coriacea, P. gayndahensis and P. papuana are recorded from Indonesia (Western New Guinea) for the first time.