bluuebunny/crossref_metadata_2025 huggingface dataset:
Case Report: Using a Remote Presence Robot to Improve Access to Physical Therapy for People with Chronic Back Disorders in an Underserved Community
Authors: Lovo Grona Stacey , Bath Brenna , Bustamante Luis , Mendez Ivar
Published: September 2016

Purpose: The purpose of this case study was to evaluate the delivery of an inter-professional (IP) spinal triage management approach to chronic back disorders using remote presence robotic technology as an innovative form of telerehabilitation in a northern Saskatchewan community. Methods: The IP team, consisting of a local nurse practitioner (NP) and a physical therapist in an urban centre, completed a comprehensive neuromusculoskeletal assessment of, and one follow-up visit with, a post-surgical spinal patient. Treatment included detailed education regarding self-management after spinal surgery, provision and progression of home exercises, and reassurance. The patient was then referred to regional, in-person physical therapy care to complete her treatment. Results: A semi-structured interview with the NP revealed a high level of satisfaction; qualitative themes included the value of IP practice and the benefit to the patient of telerehabilitation achieved through patient-centred care. In a post-treatment survey, the patient expressed a high level of satisfaction with and appreciation for the patient-centred approach and the IP team. Objective clinical improvements in spinal and straight-leg raise movements were noted at the final telerehabilitation session. Conclusion: This report demonstrates the feasibility of delivering IP spinal triage management using telerehabilitation, specifically remote presence robotics, in a remote setting. Further research should include larger scale studies that investigate health, system, and economic outcomes as well as comparative studies for other forms of telehealth technology.
2016 US lymphoid malignancy statistics by World Health Organization subtypes
Authors: Teras Lauren R. , DeSantis Carol E. , Cerhan James R. , Morton Lindsay M. , Jemal Ahmedin , Flowers Christopher R.
Published: September 2016

Collectively, lymphoid neoplasms are the fourth most common cancer and the sixth leading cause of cancer death in the United States. The authors provide contemporary lymphoid neoplasm statistics by subtype based on the 2008 World Health Organization classifications, including the most current US incidence and survival data. Presented for the first time are estimates of the total numbers of US lymphoid neoplasm cases by subtype as well as a detailed evaluation of incidence and survival statistics. In 2016, 136,960 new lymphoid neoplasms are expected. Overall lymphoma incidence rates have declined in recent years, but trends vary by subtype. Precursor lymphoid neoplasm incidence rates increased from 2001 to 2012, particularly for B‐cell neoplasms. Among the mature lymphoid neoplasms, the fastest increase was for plasma cell neoplasms. Rates also increased for mantle cell lymphoma (males), marginal zone lymphoma, hairy cell leukemia, and mycosis fungoides. Like incidence, survival for both mature T‐cell lymphomas and mature B‐cell lymphomas varied by subtype and by race. Patients with peripheral T‐cell lymphomas had among the worst 5‐year relative survival (36%‐56%, depending on race/sex), while those with mycosis fungoides had among the best survival (79%‐92%). For B‐cell lymphomas, 5‐year survival ranged from 83% to 91% for patients with marginal zone lymphoma and from 78% to 92% for those with hairy cell leukemia; but the rates were as low as 47% to 63% for patients with Burkitt lymphoma and 44% to 48% for those with plasma cell neoplasms. In general, black men had the lowest survival across lymphoid malignancy subtypes. These contemporary incidence and survival statistics are useful for developing management strategies for these cancers and can offer clues regarding their etiology. CA Cancer J Clin 2016;66:443–459. © 2016 American Cancer Society.
The Search for Herbal Antibiotics: An In-Silico Investigation of Antibacterial Phytochemicals
Authors: Snow Setzer Mary , Sharifi-Rad Javad , Setzer William
Published: September 2016

Recently, the emergence and spread of pathogenic bacterial resistance to many antibiotics (multidrug-resistant strains) have been increasing throughout the world. This phenomenon is of great concern and there is a need to find alternative chemotherapeutic agents to combat these antibiotic-resistant microorganisms. Higher plants may serve as a resource for new antimicrobials to replace or augment current therapeutic options. In this work, we have carried out a molecular docking study of a total of 561 antibacterial phytochemicals listed in the Dictionary of Natural Products, including 77 alkaloids (17 indole alkaloids, 27 isoquinoline alkaloids, 4 steroidal alkaloids, and 28 miscellaneous alkaloids), 99 terpenoids (5 monoterpenoids, 31 sesquiterpenoids, 52 diterpenoids, and 11 triterpenoids), 309 polyphenolics (87 flavonoids, 25 chalcones, 41 isoflavonoids, 5 neoflavonoids, 12 pterocarpans, 10 chromones, 7 condensed tannins, 11 coumarins, 30 stilbenoids, 2 lignans, 5 phenylpropanoids, 13 xanthones, 5 hydrolyzable tannins, and 56 miscellaneous phenolics), 30 quinones, and 46 miscellaneous phytochemicals, with six bacterial protein targets (peptide deformylase, DNA gyrase/topoisomerase IV, UDP-galactose mutase, protein tyrosine phosphatase, cytochrome P450 CYP121, and NAD+-dependent DNA ligase). In addition, 35 known inhibitors were docked with their respective targets for comparison purposes. Prenylated polyphenolics showed the best docking profiles, while terpenoids had the poorest. The most susceptible protein targets were peptide deformylases and NAD+-dependent DNA ligases.
Overview of 3D Micro- and Nanocoordinate Metrology at PTB
Authors: Dai Gaoliang , Neugebauer Michael , Stein Martin , Bütefisch Sebastian , Neuschaefer-Rube Ulrich
Published: September 2016

Improved metrological capabilities for three-dimensional (3D) measurements of various complex micro- and nanoparts are increasingly in demand. This paper gives an overview of the research activities carried out by the Physikalisch-Technische Bundesanstalt (PTB), the national metrology institute of Germany, to meet this demand. Examples of recent research advances in the development of instrumentation and calibration standards are presented. An ultra-precision nanopositioning and nanomeasuring machine (NMM) has been upgraded with regard to its mirror corner, interferometers and angle sensors, as well as its weight compensation, its electronic controller, its vibration damping stage and its instrument chamber. Its positioning noise has been greatly reduced, e.g., from 1σ = 0.52 nm to 1σ = 0.13 nm for the z-axis. The well-known tactile-optical fibre probe has been further improved with regard to its 3D measurement capability, isotropic probing stiffness and dual-sphere probing styli. A 3D atomic force microscope (AFM) and assembled cantilever probes (ACPs) have been developed which allow full 3D measurements of smaller features with sizes from a few micrometres down to tens of nanometres. In addition, several measurement standards for force, geometry, contour and microgear measurements have been introduced. A type of geometry calibration artefact, referred to as the “3D Aztec artefact”, has been developed which applies wet-etched micro-pyramidal marks for defining reference coordinates in 3D space. Compared to conventional calibration artefacts, it has advantages such as a good surface quality, a well-defined geometry and cost-effective manufacturing. A task-specific micro-contour calibration standard has been further developed for ensuring the traceability of, e.g., high-precision optical measurements at microgeometries. A workpiece-like microgear standard embodying different gear geometries (modules ranging from 0.1 mm to 1 mm) has also been developed at the Physikalisch-Technische Bundesanstalt.
WS2 as an Effective Noble-Metal Free Cocatalyst Modified TiSi2 for Enhanced Photocatalytic Hydrogen Evolution under Visible Light Irradiation
Authors: Chu Dongmei , Zhang Chunyong , Yang Ping , Du Yukou , Lu Cheng
Published: September 2016

A noble-metal free photocatalyst consisting of WS2 and TiSi2 being used for hydrogen evolution under visible light irradiation, has been successfully prepared by in-situ formation of WS2 on the surface of TiSi2 in a thermal reaction. The obtained samples were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-ray spectrometry (EDX), transmission electron microscopy (TEM), and X-ray photoelectron spectroscopy (XPS). The results demonstrate that WS2 moiety has been successfully deposited on the surface of TiSi2 and some kind of chemical bonds, such as Ti-S-W and Si-S-W, might have formed on the interface of the TiSi2 and WS2 components. Optical and photoelectrochemical investigations reveal that WS2/TiSi2 composite possesses lower hydrogen evolution potential and enhanced photogenerated charge separation and transfer efficiency. Under 6 h of visible light (λ > 420 nm) irradiation, the total amount of hydrogen evolved from the optimal WS2/TiSi2 catalyst is 596.4 μmol·g−1, which is around 1.5 times higher than that of pure TiSi2 under the same reaction conditions. This study shows a paradigm of developing the effective, scalable and inexpensive system for photocatalytic hydrogen generation.
TiO2 Solar Photocatalytic Reactor Systems: Selection of Reactor Design for Scale-up and Commercialization—Analytical Review
Authors: Abdel-Maksoud Yasmine , Imam Emad , Ramadan Adham
Published: September 2016

For the last four decades, viability of photocatalytic degradation of organic compounds in water streams has been demonstrated. Different configurations for solar TiO2 photocatalytic reactors have been used, however pilot and demonstration plants are still countable. Degradation efficiency reported as a function of treatment time does not answer the question: which of these reactor configurations is the most suitable for photocatalytic process and optimum for scale-up and commercialization? Degradation efficiency expressed as a function of the reactor throughput and ease of catalyst removal from treated effluent are used for comparing performance of different reactor configurations to select the optimum for scale-up. Comparison included parabolic trough, flat plate, double skin sheet, shallow ponds, shallow tanks, thin-film fixed-bed, thin film cascade, step, compound parabolic concentrators, fountain, slurry bubble column, pebble bed and packed bed reactors. Degradation efficiency as a function of system throughput is a powerful indicator for comparing the performance of photocatalytic reactors of different types and geometries, at different development scales. Shallow ponds, shallow tanks and fountain reactors have the potential of meeting all the process requirements and a relatively high throughput are suitable for developing into continuous industrial-scale treatment units given that an efficient immobilized or supported photocatalyst is used.
Effect of an Sb-Doped SnO2 Support on the CO-Tolerance of Pt2Ru3 Nanocatalysts for Residential Fuel Cells
Authors: Ogihara Yoshiyuki , Yano Hiroshi , Watanabe Masahiro , Iiyama Akihiro , Uchida Hiroyuki
Published: September 2016

We prepared monodisperse Pt2Ru3 nanoparticles supported on carbon black and Sb-doped SnO2 (denoted as Pt2Ru3/CB and Pt2Ru3/Sb-SnO2) with identical alloy composition and particle size distribution by the nanocapsule method. The activities for the hydrogen oxidation reaction (HOR) of these anode catalysts were examined in H2-saturated 0.1 M HClO4 solution in both the presence and absence of carbon monoxide by use of a channel flow electrode at 70 °C. It was found that the CO-tolerant HOR mass activity at 0.02 V versus a reversible hydrogen electrode (RHE) on the Pt2Ru3/Sb-SnO2 electrode was higher than that at the Pt2Ru3/CB electrode in 0.1 M HClO4 solution saturated with 1000 ppm CO (H2-balance). The CO tolerance mechanism of these catalysts was investigated by in situ attenuated total reflection Fourier transform infrared reflection-adsorption spectroscopy (ATR-FTIRAS) in 1% CO/H2-saturated 0.1 M HClO4 solution at 60 °C. It was found, for the Pt2Ru3/Sb-SnO2 catalyst, that the band intensity of CO linearly adsorbed (COL) at step/edge sites was suppressed, together with a blueshift of the COL peak at terrace sites. On this surface, the HOR active sites were concluded to be more available than those on the CB-supported catalyst surface. The observed changes in the adsorption states of CO can be ascribed to an electronic modification effect by the Sb-SnO2 support.
Highly Efficient Tetranuclear ZnII2LnIII2 Catalysts for the Friedel–Crafts Alkylation of Indoles and Nitrostyrenes
Authors: Kumar Prashant , Lymperopoulou Smaragda , Griffiths Kieran , Sampani Stavroula , Kostakis George
Published: September 2016

We demonstrate for the first time the high efficacy of tetranuclear ZnII2LnIII2 coordination clusters (CCs) as catalysts for the Friedel–Crafts (FC) alkylation of indoles with a range of trans-β-nitrostyrenes. The reaction proceeds in good to excellent yields (76%–99%) at room temperature with catalyst loadings as low as 1.0 mol %.
Reliance on Pumped Mother’s Milk Has an Environmental Impact
Authors: Becker Genevieve , Ryan-Fogarty Yvonne
Published: September 2016

Breastfeeding is an environmentally friendly process; however when feeding relies on pumped mother’s milk, the environmental picture changes. Waste plastics and heavy metals raise concerns regarding resource efficiency, waste treatment, and detrimental effects on health. Reliance on pumped milk rather than breastfeeding may also effect obesity and family size, which in turn have further environmental impacts. Information on pump equipment rarely includes environmental information and may focus on marketing the product for maximum profit. In order for parents, health workers, and health policy makers to make informed decisions about the reliance on pumped mother’s milk, they need information on the broad and far reaching environmental aspects. There was no published research found that examined the environmental impact of using pumped mother’s milk. A project is ongoing to examine this issue.
Axial Dynamic Stiffness of Tubular Piles in Viscoelastic Soil
Authors: Bayat Mehdi , Andersen Lars , Ibsen Lars
Published: September 2016

Large offshore wind turbines are founded on jacket structures. In this study, an elastic full-space jacket structure foundation in an elastic and viscoelastic medium is investigated by using boundary integral equations. The jacket structure foundation is modeled as a hollow, long circular cylinder when the dynamic vertical excitation is applied. The smooth surface along the entire interface is considered. The Betti reciprocal theorem along with Somigliana’s identity and Green’s function are employed to drive the dynamic stiffness of jacket structures. Modes of the resonance and anti-resonance are presented in series of Bessel’s function. Important responses, such as dynamic stiffness and phase angle, are compared for different values of the loss factor as the material damping, Young’s modulus and Poisson’s ratio in a viscoelastic soil. Results are verified with known results reported in the literature. It is observed that the dynamic stiffness fluctuates with the loss factor, and the turning point is independent of the loss factor while the turning point increases with load frequency. It is seen that the non-dimensional dynamic stiffness is dependent on Young’s modulus and Poisson’s ratio, whilst the phase angle is independent of the properties of the soil. It is shown that the non-dimensional dynamic stiffness changes linearly with high-frequency load. The conclusion from the results of this study is that the material properties of soil are significant parameters in the dynamic stiffness of jacket structures, and the presented approach can unfold the behavior of soil and give an approachable physical meaning for wave propagation.
Simplification of a Mechanistic Model of Biomass Combustion for On-Line Computations
Authors: Boriouchkine Alexandre , Jämsä-Jounela Sirkka-Liisa
Published: September 2016

Increasing utilization of intermittent energy resources requires flexibility from energy boilers which can be achieved with advanced control methods employing dynamic process models. The performance of the model-based control methods depends on the ability of the underlying model to describe combustion phenomena under varying power demand. This paper presents an approach to the simplification of a mechanistic model developed for combustion phenomena investigation. The aim of the approach is to simplify the dynamic model of biomass combustion for applications requiring fast computational times while retaining the ability of the model to describe the underlying combustion phenomena. The approach for that comprises three phases. In the first phase, the main mechanisms of heat and mass transfer and limiting factors of the reactions are identified in each zone. In the second phase, each of the partial differential equations from the full scale model are reduced to a number of ordinary differential equations (ODEs) defining the overall balances of the zones. In the last phase, mathematical equations are formulated based on the mass and energy balances formed in the previous step. The simplified model for online computations was successfully built and validated against industrial data.
Irradiation Maintains Functional Components of Dry Hot Peppers (Capsicum annuum L.) under Ambient Storage
Authors: Iqbal Qumer , Amjad Muhammad , Asi Muhammad , Nawaz Aamir , Khan Samiya , Ariño Agustin , Ahmad Tanveer
Published: September 2016

Hot peppers used as natural flavoring and coloring agents are usually irradiated in prepacked form for decontamination. The effects of gamma radiation on the stability of functional components such as capsaicinoids and antioxidant compounds (carotenoids, ascorbic acid and total phenolics) were investigated in hot peppers (Capsicum annuum). Whole dried peppers packed in polyethylene bags were gamma irradiated at 0 (control), 2, 4, and 6 kGy and subsequently stored at 25 °C for 90 days. The irradiation dose did not substantially affect the initial contents of capsaicinoids, ascorbic acid and total phenolics, though the concentration of carotenoids declined by 8% from the control (76.9 mg/100 g) to 6 kGy radiation dose (70.7 mg/100 g). Similarly, during storage for 90 days at ambient temperature the concentrations of capsaicinoids and total phenolics remained fairly stable with mean percent reductions from 3.3% to 4.2%, while the levels of total carotenoids and ascorbic acid significantly (p < 0.05) declined by 12% and 14%, respectively. Overall, neither irradiation nor subsequent ambient storage could appreciably influence the contents of functional components in hot peppers. These results revealed that gamma irradiation up to 6 kGy can be safely used for decontamination to meet the needs for overseas markets without compromising product quality.
Estimating the Additional Greenhouse Gas Emissions in Korea: Focused on Demolition of Asbestos Containing Materials in Building
Authors: Kim Young-Chan , Hong Won-Hwa , Zhang Yuan-Long , Son Byeung-Hun , Seo Youn-Kyu , Choi Jun-Ho
Published: September 2016

When asbestos containing materials (ACM) must be removed from the building before demolition, additional greenhouse gas (GHG) emissions are generated. However, precedent studies have not considered the removal of ACM from the building. The present study aimed to develop a model for estimating GHG emissions created by the ACM removal processes, specifically the removal of asbestos cement slates (ACS). The second objective was to use the new model to predict the total GHG emission produced by ACM removal in the entire country of Korea. First, an input-equipment inventory was established for each step of the ACS removal process. Second, an energy consumption database for each equipment type was established. Third, the total GHG emission contributed by each step of the process was calculated. The GHG emissions generated from the 1,142,688 ACS-containing buildings in Korea was estimated to total 23,778 tonCO2eq to 132,141 tonCO2eq. This study was meaningful in that the emissions generated by ACS removal have not been studied before. Furthermore, the study deals with additional problems that can be triggered by the presence of asbestos in building materials. The method provided in this study is expected to contribute greatly to the calculation of GHG emissions caused by ACM worldwide.
Determination of Histamine in Silages Using Nanomaghemite Core (γ-Fe2O3)-Titanium Dioxide Shell Nanoparticles Off-Line Coupled with Ion Exchange Chromatography
Authors: Cernei Natalia , Lackova Zuzana , Guran Roman , Hynek David , Skladanka Jiri , Horky Pavel , Zitka Ondrej , Adam Vojtech
Published: September 2016

The presence of biogenic amines is a hallmark of degraded food and its products. Herein, we focused on the utilization of magnetic nanoparticles off-line coupled with ion exchange chromatography with post-column ninhydrin derivatization and Vis detection for histamine (Him) separation and detection. Primarily, we described the synthesis of magnetic nanoparticles with nanomaghemite core (γ-Fe2O3) functionalized with titanium dioxide and, then, applied these particles to specific isolation of Him. To obtain further insight into interactions between paramagnetic particles’ (PMP) surface and Him, a scanning electron microscope was employed. It was shown that binding of histamine causes an increase of relative current response of deprotonated PMPs, which confirmed formation of Him-PMPs clusters. The recovery of the isolation showed that titanium dioxide-based particles were able to bind and preconcentrate Him with recovery exceeding 90%. Finally, we successfully carried out the analyses of real samples obtained from silage. We can conclude that our modified particles are suitable for Him isolation, and thus may serve as the first isolation step of Him from biological samples, as it is demonstrated on alfalfa seed variety Tereza silage.
Improving Seasonal Land Cover Maps of Poyang Lake Area in China by Taking into Account Logical Transitions
Authors: Yang Guang , Fang Shenghui , Dian Yuanyong , Bi Chuang
Published: September 2016

Land cover maps are fundamental materials for resource management and change detection. Remote sensing technology is crucial for fast mapping with low cost. However, besides the inherent classification errors in the land cover products, numerous illogical transitions exist between the neighboring time points. In this study, we introduce a series of logical codes for all the land cover types according to the ecological rules in the study area. The codes represent the transformational logicality of species between different seasons. The classification performance and the codes for all the seasons are imposed on the initial land cover maps which have been produced independently by the conventional hierarchical strategy. We exploit the proposed modified hierarchical mapping strategy to map the land cover of Poyang Lake Basin area, Middle China. The illogical transitions between neighboring seasons and the accuracies based on the labeled samples are calculated for both the initial and modified strategies. The number of illogical pixels have been reduced by 13%–35% for different seasons and the average accuracy has been improved by 9.7% for the specific land cover maps. The accuracy of land cover changes has also presented great improvement of the proposed strategy. The experimental results have suggested the scheme is effective.
Small GTPases and Stress Responses of vvran1 in the Straw Mushroom Volvariella volvacea
Authors: Yan Jun-Jie , Xie Bin , Zhang Lei , Li Shao-Jie , Van Peer Arend , Wu Ta-Ju , Chen Bing-Zhi , Xie Bao-Gui
Published: September 2016

Small GTPases play important roles in the growth, development and environmental responses of eukaryotes. Based on the genomic sequence of the straw mushroom Volvariella volvacea, 44 small GTPases were identified. A clustering analysis using human small GTPases as the references revealed that V. volvacea small GTPases can be grouped into five families: nine are in the Ras family, 10 are in the Rho family, 15 are in the Rab family, one is in the Ran family and nine are in the Arf family. The transcription of vvran1 was up-regulated upon hydrogen peroxide (H2O2) stress, and could be repressed by diphenyleneiodonium chloride (DPI), a NADPH oxidase-specific inhibitor. The number of vvran1 transcripts also increased upon cold stress. Diphenyleneiodonium chloride, but not the superoxide dismutase (SOD) inhibitor diethy dithiocarbamate (DDC), could suppress the up-regulation of vvran1 gene expression to cold stress. These results combined with the high correlations between gene expression and superoxide anion (O2−) generation indicated that vvran1 could be one of the candidate genes in the downstream of O2− mediated pathways that are generated by NADPH oxidase under low temperature and oxidative stresses.
Identification of Bioactivity, Volatile and Fatty Acid Profile in Supercritical Fluid Extracts of Mexican arnica
Authors: García-Pérez J. , Cuéllar-Bermúdez Sara , Arévalo-Gallegos Alejandra , Rodríguez-Rodríguez José , Iqbal Hafiz , Parra-Saldivar Roberto
Published: September 2016

Supercritical fluid extraction (SFE) is a sustainable technique used for the extraction of lipophilic metabolites such as pigments and fatty acids. Arnica plant is considered a potential candidate material with high antioxidant and antimicrobial activities. Therefore, in this study, a locally available Heterotheca inuloides, also known as Mexican arnica, was analyzed for the extraction of high-value compounds. Based on different pressure (P), temperature (T), and co-solvent (CoS), four treatments (T) were prepared. A maximum 7.13% yield was recovered from T2 (T = 60 °C, P = 10 MPa, CoS = 8 g/min), followed by 6.69% from T4 (T = 60 °C, P = 30 MPa, CoS = 4 g/min). Some bioactive sesquiterpenoids such as 7-hydroxycadalene, caryophyllene and δ-cadinene were identified in the extracts by GC/MS. The fatty acid profile revealed that the main components were palmitic acid (C16:0), followed by linoleic acid (C18:2ω6c), α-linolenic acid (C18:3ω3) and stearic acid (C18:0) differing in percent yield per treatment. Antibacterial activities were determined by the agar diffusion method, indicating that all the treatments exerted strong antibacterial activity against S. aureus, C. albicans, and E. coli strains. The antioxidant capacity of the extracts was also measured by three in vitro assays, DPPH, TEAC and FRAP, using Trolox as a standard. Results showed high antioxidant capacity enabling pharmaceutical applications of Mexican arnica.
A Protocol to Enhance INS1E and MIN6 Functionality—The Use of Theophylline
Authors: Groot Nibbelink Milou , Marchioli Giulia , Moroni Lorenzo , Karperien Marcel , Van Apeldoorn Aart
Published: September 2016

In vitro research in the field of type I diabetes is frequently limited by the availability of a functional model for islets of Langerhans. This method shows that by the addition of theophylline to the glucose buffers, mouse insulinoma MIN6 and rat insulinoma INS1E pseudo-islets can serve as a model for islets of Langerhans for in vitro research. The effect of theophylline is dose- and cell line-dependent, resulting in a minimal stimulation index of five followed by a rapid return to baseline insulin secretion by reducing glucose concentrations after a first high glucose stimulation. This protocol solves issues concerning in vitro research for type I diabetes as donors and the availability of primary islets of Langerhans are limited. To avoid the limitations of using human donor material, cell lines represent a valid alternative. Many different β cell lines have been reported, but the lack of reproducible responsiveness to glucose stimulation remains a challenge.
Apoptosis in Porcine Pluripotent Cells: From ICM to iPSCs
Authors: Kim Eunhye , Hyun Sang-Hwan
Published: September 2016

Pigs have great potential to provide preclinical models for human disease in translational research because of their similarities with humans. In this regard, porcine pluripotent cells, which are able to differentiate into cells of all three primary germ layers, might be a suitable animal model for further development of regenerative medicine. Here, we describe the current state of knowledge on apoptosis in pluripotent cells including inner cell mass (ICM), epiblast, embryonic stem cells (ESCs), and induced pluripotent stem cells (iPSCs). Information is focused on the apoptotic phenomenon in pluripotency, maintenance, and differentiation of pluripotent stem cells and reprogramming of somatic cells in pigs. Additionally, this review examines the multiple roles of apoptosis and summarizes recent progress in porcine pluripotent cells.
A Supervised Classification Method for Levee Slide Detection Using Complex Synthetic Aperture Radar Imagery
Authors: Marapareddy Ramakalavathi , Aanstoos James , Younan Nicolas
Published: September 2016

The dynamics of surface and sub-surface water events can lead to slope instability, resulting in anomalies such as slough slides on earthen levees. Early detection of these anomalies by a remote sensing approach could save time versus direct assessment. We have implemented a supervised Mahalanobis distance classification algorithm for the detection of slough slides on levees using complex polarimetric Synthetic Aperture Radar (polSAR) data. The classifier output was followed by a spatial majority filter post-processing step that improved the accuracy. The effectiveness of the algorithm is demonstrated using fully quad-polarimetric L-band Synthetic Aperture Radar (SAR) imagery from the NASA Jet Propulsion Laboratory’s (JPL’s) Uninhabited Aerial Vehicle Synthetic Aperture Radar (UAVSAR). The study area is a section of the lower Mississippi River valley in the southern USA. Slide detection accuracy of up to 98 percent was achieved, although the number of available slides examples was small.
How Are Feedbacks Represented in Land Models?
Authors: Chen Yang , Bakker Martha , Ligtenberg Arend , Bregt Arnold
Published: September 2016

Land systems are characterised by many feedbacks that can result in complex system behaviour. We defined feedbacks as the two-way influences between the land use system and a related system (e.g., climate, soils and markets), both of which are encompassed by the land system. Land models that include feedbacks thus probably more accurately mimic how land systems respond to, e.g., policy or climate change. However, representing feedbacks in land models is a challenge. We reviewed articles incorporating feedbacks into land models and analysed each with predefined indicators. We found that (1) most modelled feedbacks couple land use systems with transport, soil and market systems, while only a few include feedbacks between land use and social systems or climate systems; (2) equation-based land use models that follow a top-down approach prevail; and (3) feedbacks’ effects on system behaviour remain relatively unexplored. We recommend that land system modellers (1) consider feedbacks between land use systems and social systems; (2) adopt (bottom-up) approaches suited to incorporating spatial heterogeneity and better representing land use decision-making; and (3) pay more attention to nonlinear system behaviour and its implications for land system management and policy.
Logistics Is about Competitiveness and More
Authors: Kasarda John
Published: September 2016

Stripped to its basics, logistics is about capturing competitive advantage and creating customer value, not just optimizing costs.[...]
Enhancement of TiO2 NPs Activity by Fe3O4 Nano-Seeds for Removal of Organic Pollutants in Water
Authors: Villa Silvia , Caratto Valentina , Locardi Federico , Alberti Stefano , Sturini Michela , Speltini Andrea , Maraschi Federica , Canepa Fabio , Ferretti Maurizio
Published: September 2016

The enhancement of the photocatalytic activity of TiO2 nanoparticles (NPs), synthesized in the presence of a very small amount of magnetite (Fe3O4) nanoparticles, is here presented and discussed. From X-ray diffraction (XRD) and differential scanning calorimetry (DSC) analyses, the crystallinity of TiO2 nanoparticles (NPs) seems to be affected by Fe3O4, acting as nano-seeds to improve the tetragonal TiO2 anatase structure with respect to the amorphous one. Photocatalytic activity data, i.e., the degradation of methylene blue and the Ofloxacin fluoroquinolone emerging pollutant, give evidence that the increased crystalline structure of the NPs, even if correlated to a reduced surface to mass ratio (with respect to commercial TiO2 NPs), enhances the performance of this type of catalyst. The achievement of a relatively well-defined crystal structure at low temperatures (Tmax = 150 °C), preventing the sintering of the TiO2 NPs and, thus, preserving the high density of active sites, seems to be the keystone to understand the obtained results.
Quantum Incompatibility in Collective Measurements
Authors: Carmeli Claudio , Heinosaari Teiko , Reitzner Daniel , Schultz Jussi , Toigo Alessandro
Published: September 2016

We study the compatibility (or joint measurability) of quantum observables in a setting where the experimenter has access to multiple copies of a given quantum system, rather than performing the experiments on each individual copy separately. We introduce the index of incompatibility as a quantifier of incompatibility in this multi-copy setting, as well as the notion of the compatibility stack representing various compatibility relations present in a given set of observables. We then prove a general structure theorem for multi-copy joint observables and use it to prove that all abstract compatibility stacks with three vertices have realizations in terms of quantum observables.
An Overview of the Medical Applications of Marine Skeletal Matrix Proteins
Authors: Rahman M.
Published: September 2016

In recent years, the medicinal potential of marine organisms has attracted increasing attention. This is due to their immense diversity and adaptation to unique ecological niches that has led to vast physiological and biochemical diversification. Among these organisms, marine calcifiers are an abundant source of novel proteins and chemical entities that can be used for drug discovery. Studies of the skeletal organic matrix proteins of marine calcifiers have focused on biomedical applications such as the identification of growth inducing proteins that can be used for bone regeneration, for example, 2/4 bone morphogenic proteins (BMP). Although a few reports on the functions of proteins derived from marine calcifiers can be found in the literature, marine calcifiers themselves remain an untapped source of proteins for the development of innovative pharmaceuticals. Following an overview of the current knowledge of skeletal organic matrix proteins from marine calcifiers, this review will focus on various aspects of marine skeletal protein research including sources, biosynthesis, structures, and possible strategies for chemical or physical modification. Special attention will be given to potential medical applications and recent discoveries of skeletal proteins and polysaccharides with biologically appealing characteristics. In addition, I will introduce an effective protocol for sample preparation and protein purification that includes isolation technology for biopolymers (of both soluble and insoluble organic matrices) from coralline algae. These algae are a widespread but poorly studied group of shallow marine calcifiers that have great potential for marine drug discovery.
The Unified Creep-Fatigue Equation for Stainless Steel 316
Authors: Liu Dan , Pons Dirk , Wong Ee-hua
Published: September 2016

Background—The creep-fatigue properties of stainless steel 316 are of interest because of the wide use of this material in demanding service environments, such as the nuclear industry. Need—A number of models exist to describe creep-fatigue behaviours, but they are limited by the need to obtain specialized coefficients from a large number of experiments, which are time-consuming and expensive. Also, they do not generalise to other situations of temperature and frequency. There is a need for improved formulations for creep-fatigue, with coefficients that determinable directly from the existing and simple creep-fatigue tests and creep rupture tests. Outcomes—A unified creep-fatigue equation is proposed, based on an extension of the Coffin-Manson equation, to introduce dependencies on temperature and frequency. The equation may be formulated for strain as ε p = C 0 c ( T , t , ε p ) N − β 0 , or as a power-law ε p = C 0 c ( T , t ) N − β 0 b ( T , t ) . These were then validated against existing experimental data. The equations provide an excellent fit to data (r2 = 0.97 or better). Originality—This work develops a novel formulation for creep-fatigue that accommodates temperature and frequency. The coefficients can be obtained with minimum experimental effort, being based on standard rather than specialized tests.
Enhancing the Antioxidant Ability of Trametes versicolor Polysaccharopeptides by an Enzymatic Hydrolysis Process
Authors: Jhan Mei-Hsin , Yeh Ching-Hua , Tsai Chia-Chun , Kao Ching-Tian , Chang Chao-Kai , Hsieh Chang-Wei
Published: September 2016

Polysaccharopeptides (PSPs) are among the main bioactive constituents of Trametes versicolor (T. versicolor). The purpose of this research was to investigate the antioxidant activities of enzymatic hydrolysates obtained from T. versicolor polysaccharopeptides by 80 U/mL β-1,3-glucanase (PSPs-EH80). The half-inhibitory concentration (IC50) of PSPs-EH80 in metal chelating assay, ABTS and DPPH radical scavenging test results were 0.83 mg/mL, 0.14 mg/mL and 0.52 mg/mL, respectively, which were lower than that of PSPs-EH 20 U/mL. The molecular weights of the PSPs-EH80 hydrolysates were 300, 190, 140 and 50 kDa, respectively, and the hydrolysis of polysaccharides by β-1,3-glucanase did not change the original functional group. PSPs-EH80 reduced the reactive oxygen species (ROS) content at least twice that of treatment without PSPs-EH80. In addition, an oxidative damage test showed that PSPs-EH80 can improve HaCaT cell survival. According to our results, PSP demonstrates the potential of anti-oxidative damage; besides, enzyme hydrolysis can improve the ability of the PSP.
Evaluation of PVP/Au Nanocomposite Fibers as Heterogeneous Catalysts in Indole Synthesis
Authors: Savva Ioanna , Kalogirou Andreas , Achilleos Mariliz , Vasile Eugenia , Koutentis Panayiotis , Krasia-Christoforou Theodora
Published: September 2016

Electrospun nanocomposite fibers consisting of crosslinked polyvinylpyrrolidone (PVP) chains and gold nanoparticles (Au NPs) were fabricated, starting from highly stable PVP/Au NP colloidal solutions with different NP loadings, followed by thermal treatment. Information on the morphological characteristics of the fibers and of the embedded Au NPs was obtained by electron microscopy. Cylindrical, bead-free fibers were visualized by Scanning Electron Microscopy (SEM) while Transmission Electron Microscopy (TEM) and Energy Diffraction X-ray (EDX) analysis supported the presence of Au NPs within the fibers and gave information on their morphologies and average diameters. These materials were briefly evaluated as heterogeneous catalytic supports for the gold-catalyzed intramolecular cyclisation of 2‑(phenylethynyl)aniline to form 2-phenyl-1H-indole. The performance of the gold catalyst was strongly dependent on the Au NP size, with the system containing the smallest Au NPs being the more effective. Moreover, a slight drop of their catalytic efficiency was observed after three consecutive reaction runs, which was attributed to morphological changes as a consequence of fiber merging.
Synthesis of High-Molecular-Weight Multifunctional Glycerol Polyhydroxyurethanes PHUs
Authors: Nohra Bassam , Candy Laure , Blanco Jean-François , Raoul Yann , Mouloungui Zéphirin
Published: September 2016

Glycerol carbonate acrylate is a 5-membered cyclic carbonate synthesized from glycerol that is used as a chemical coupling agent and has proven highly suitable for use in the synthesis of multifunctional polyhydroxyurethanes (PHUs). The multifunctionality of the structure of PHUs is determined by the density of the carbon-amine groups generated by the Aza-Michael reaction and that of the urethane groups and adjacent primary and secondary hydroxyl groups generated by aminolysis. Glycerol carbonate acrylate is polymerized with polyfunctional mono-, di-, tri, and tetra-amines, by type-AB polyaddition, either in bulk or in solution, through stepwise or one-pot reaction strategies in the absence of added catalysts. These approaches result in the generation of linear, interchain, and crosslinked structures, through the polyaddition of linear and branched amines to the ethylene and cyclic carbonate sites of glycerol carbonate acrylate. The resulting collection of organic molecules gives rise to polyethylene amino ester PHUs with a high molar mass, exceeding 20,000 g·mol−1, with uniform dispersity.
Spectroelectrochemical Study of Carbon Monoxide and Ethanol Oxidation on Pt/C, PtSn(3:1)/C and PtSn(1:1)/C Catalysts
Authors: Rizo Rubén , Lázaro María , Pastor Elena , García Gonzalo
Published: September 2016

PtSn-based catalysts are one of the most active materials toward that contribute ethanol oxidation reaction (EOR). In order to gain a better understanding of the Sn influence on the carbon monoxide (principal catalyst poison) and ethanol oxidation reactions in acidic media, a systematic spectroelectrochemical study was carried out. With this end, carbon-supported PtSnx (x = 0, 1/3 and 1) materials were synthesized and employed as anodic catalysts for both reactions. In situ Fourier transform infrared spectroscopy (FTIRS) and differential electrochemical mass spectrometry (DEMS) indicate that Sn diminishes the amount of bridge bonded CO (COB) and greatly improves the CO tolerance of Pt-based catalysts. Regarding the effect of Sn loading on the EOR, it enhances the catalytic activity and decreases the onset potential. FTIRS and DEMS analysis indicate that the C-C bond scission occurs at low overpotentials and at the same potential values regardless of the Sn loading, although the amount of C-C bond breaking decreases with the rise of Sn in the catalytic material. Therefore, the elevated catalytic activity toward the EOR at PtSn-based electrodes is mainly associated with the improved CO tolerance and the incomplete oxidation of ethanol to form acetic acid and acetaldehyde species, causing the formation of a higher amount of both C2 products with the rise of Sn loading.
Rotation of Magnetization Derived from Brownian Relaxation in Magnetic Fluids of Different Viscosity Evaluated by Dynamic Hysteresis Measurements over a Wide Frequency Range
Authors: Ota Satoshi , Kitaguchi Ryoichi , Takeda Ryoji , Yamada Tsutomu , Takemura Yasushi
Published: September 2016

The dependence of magnetic relaxation on particle parameters, such as the size and anisotropy, has been conventionally discussed. In addition, the influences of external conditions, such as the intensity and frequency of the applied field, the surrounding viscosity, and the temperature on the magnetic relaxation have been researched. According to one of the basic theories regarding magnetic relaxation, the faster type of relaxation dominates the process. However, in this study, we reveal that Brownian and Néel relaxations coexist and that Brownian relaxation can occur after Néel relaxation despite having a longer relaxation time. To understand the mechanisms of Brownian rotation, alternating current (AC) hysteresis loops were measured in magnetic fluids of different viscosities. These loops conveyed the amplitude and phase delay of the magnetization. In addition, the intrinsic loss power (ILP) was calculated using the area of the AC hysteresis loops. The ILP also showed the magnetization response regarding the magnetic relaxation over a wide frequency range. To develop biomedical applications of magnetic nanoparticles, such as hyperthermia and magnetic particle imaging, it is necessary to understand the mechanisms of magnetic relaxation.
A Shared Focus: Comparing the Australian, Canadian, United Kingdom and United States Pharmacy Learning Outcome Frameworks and the Global Competency Framework
Authors: Stupans Ieva , Atkinson Jeffrey , Meštrović Arijana , Nash Rose , Rouse Michael
Published: September 2016

This paper presents an analysis of the end of degree expectations, expressed as learning outcomes, for pharmacy graduates from Australia, Canada, United Kingdom and United States. The authors compare the end of degree expectations, through mapping these requirements to the International Pharmaceutical Federation (FIP) Global Competency Framework (GbCF). The anticipated end of degree expectations are similar but also reveal some individual characteristics. Irrespective of degree title, achievement of learning outcomes specified in any one of the four jurisdictions should enable students to become pharmacists who are patient-orientated medicines experts. The mapping provides impetus for cross-border institutional networking to generate a dependable set of assessment tools across national borders developing a common metric for outcome assessment irrespective of different program delivery.
A Scale-Driven Change Detection Method Incorporating Uncertainty Analysis for Remote Sensing Images
Authors: Hao Ming , Shi Wenzhong , Zhang Hua , Wang Qunming , Deng Kazhong
Published: September 2016

Change detection (CD) based on remote sensing images plays an important role in Earth observation. However, the CD accuracy is usually affected by sunlight and atmospheric conditions and sensor calibration. In this study, a scale-driven CD method incorporating uncertainty analysis is proposed to increase CD accuracy. First, two temporal images are stacked and segmented into multiscale segmentation maps. Then, a pixel-based change map with memberships belonging to changed and unchanged parts is obtained by fuzzy c-means clustering. Finally, based on the Dempster-Shafer evidence theory, the proposed scale-driven CD method incorporating uncertainty analysis is performed on the multiscale segmentation maps and the pixel-based change map. Two experiments were carried out on Landsat-7 Enhanced Thematic Mapper Plus (ETM+) and SPOT 5 data sets. The ratio of total errors can be reduced to 4.0% and 7.5% for the ETM+ and SPOT 5 data sets in this study, respectively. Moreover, the proposed approach outperforms some state-of-the-art CD methods and provides an effective solution for CD.
A Novel Tri-Training Technique for Semi-Supervised Classification of Hyperspectral Images Based on Diversity Measurement
Authors: Tan Kun , Zhu Jishuai , Du Qian , Wu Lixin , Du Peijun
Published: September 2016

This paper introduces a novel semi-supervised tri-training classification algorithm based on diversity measurement for hyperspectral imagery. In this algorithm, three measures of diversity, i.e., double-fault measure, disagreement metric and correlation coefficient, are applied to select the optimal classifier combination from different classifiers, e.g., support vector machine (SVM), multinomial logistic regression (MLR), extreme learning machine (ELM) and k-nearest neighbor (KNN). Then, unlabeled samples are selected using an active learning (AL) method, and consistent results of any other two classifiers combined with a spatial neighborhood information extraction strategy are employed to predict their labels. Moreover, a multi-scale homogeneity (MSH) method is utilized to refine the classification result with the highest accuracy in the classifier combination, generating the final classification result. Experiments on three real hyperspectral data indicate that the proposed approach can effectively improve classification performance.