bluuebunny/crossref_metadata_2025 huggingface dataset:
The Importance of MPV as a Marker of Subclinical Inflammation in FMF Patients and It’s Correlation with Disease Severity
Authors: ÇELİKER Mesut , KAZAN Sinan , TUNCA Onur , SARI Alper , KÖROĞLU Mustafa , ULU Mennune Sena
Published: August 2021

Objective: Inflammation markers increase during Familial Mediterranean Fever (FMF) attacks and often return to normal within a few days. It is known that a subclinical inflammation continues in FMF patients in the inter-episode period, which increases the risk of developing amyloidosis. In recent years, several works have been conducted showing the relationship between platelet indices and inflammation, such as platelet count (PLT), platelet distribution width (PDW), mean platelet volume (MPV), plateletrite (PCT). In this study, we aimed to investigate the relationship between platelet indices and disease severity in FMF patients without attacks.

Method: The records of all FMF patients followed by us were reviewed retrospectively. Patients with a hematological or oncological disease, patients with data deficiency for the study, and patients under 18 years of age were excluded. While the laboratory data were recorded, the condition of patients to be at least 3 months without attack was required. As the control group, the automation records of all healthcare professionals working in the internal medicine clinic of our hospital were examined. Our clinical staff, who did not have chronic diseases and regular drug use, were taken as a healthy control group. 173 patients and 20 control groups who met the conditions mentioned above were included in the study. Platelet indices were compared between patient and control groups.

Results: It was determined that the value of MPV, one of the platelet indices, in the patient group was statistically significantly higher than the value in the healthy control group (p = 0.029). MPV was also found to correlate with disease severity (p
Subulina octona (Bruguière, 1798) – a new greenhouse species for the Czech Republic (Mollusca: Gastropoda: Subulinidae)
Authors: Juřičková Lucie
Published: August 2021

The occurrence of land snail Subulina octona (Bruguière 1798) (Gastropoda: Subulinidae) is reported from the Czech Republic greenhouse for the first time. Molluscan communities of two new Bohemian greenhouses are characterized.
Self-preservation and the Transformation of Nature
Authors: Iorizzo Dolores ,   Institute of Philosophy, Russian Academy of Sciences
Published: August 2021

Garber demonstrates the shortcomings of a popular and idealised version of Baconian scientific method set against his close reading of Bacon’s Novum Organum II. The results of Garber’s analysis show that Bacon had not one but two philosophies, both of which were informed by his matter theory and speculative cosmology. This paper draws out the implications of Garber’s reading of Baconian induction in physics transferred to the natural sciences, and draws attention to the ultimate aim of Bacon’s philosophical programme as the prolongation of life.
Platonism about Abstracta
Authors: Dumsday Travis ,   Evangelical Philosophical Society
Published: August 2021

I present a new argument to the effect that platonism about abstract entities (at least when combined with a specific understanding of the abstract / concrete distinction) undermines metaphysical naturalism and provides some support to theism. I further suggest that there are ways of extending this line of reasoning to point toward one or another more specific varieties of Christian theism.
The Need for Thisnesses
Authors: Hasker William ,   Evangelical Philosophical Society
Published: August 2021

Richard Swinburne is an emergent dualist. One feature of his view is the need for a “thisness” or haecceity that makes each soul the soul that it is, distinct from other souls that may be indistinguishable from it in all qualitative respects. I argue that there is no need for thisnesses.
Physicalism and the Incarnation Once More
Authors: Mullins R. T. ,   Evangelical Philosophical Society
Published: August 2021

In a previous publication, I offered a novel argument against physicalist approaches to the Incarnation called “the Two Sons Worry.” In brief, I argued that a physicalist who is committed to the ecumenical teachings about the Incarnation cannot easily escape the worry that there are two persons in Jesus Christ. Keith Hess has recently pointed out a flaw in the argument that I present. In this paper, I offer a reply that fixes the argument, thus leaving the problem for the physicalist intact.
Analyzing Doctrine: A Précis
Authors: Woznicki Christopher ,   Evangelical Philosophical Society
Published: August 2021

In this précis I introduce the topic of the symposium, namely, Oliver D. Crisp’s book, Analyzing Doctrine: Toward a Systematic Theology. I discuss the impetus behind the symposium, provide a précis of Analyzing Doctrine, and preview the various responses to the book given by his interlocutors. I conclude by highlighting some possible new directions for analytic theology.
On Maximal Simplicity
Authors: Sutanto N. Gray ,   Evangelical Philosophical Society
Published: August 2021

This essay engages with Oliver D. Crisp’s parsimonious model of divine simplicity while offering a defense of a maximal account of simplicity. Specifically, I clarify (1) the way in with Reformed orthodox theologians, like Gisbertus Voetius, anticipate something like Crisp’s model, (2) that pure actuality is an explication, rather than an entailment, of the doctrine of simplicity, and (3) that the doctrine of simplicity remains consistent with epistemic modesty in relation to theological matters.
Crisp on Conciliar Authority
Authors: Wessling Jordan ,   Evangelical Philosophical Society
Published: August 2021

In Analyzing Doctrine: Toward a Systematic eology, Oliver Crisp infers from a general principle concerning God’s providential care for the church that it is implausible that God would allow substantial error on the central theological promulgations of an ecumenical council. is conclusion is then used specifically against contemporary neo-monothelites, who consciously contravene the dyothelite teachings of the third Council of Constantinople. In this paper, I raise several doubts about the inference utilized by Crisp against these neo-monothelites, and I seek to point to a more promising manner of upholding the deliverances of the ecumenical councils.
Utilização do software IRAMUTEQ em pesquisa de abordagem qualitativa: relato de experiência
Authors: Góes Fernanda Garcia Bezerra , Santos Andressa Silva Torres dos , Campos Brenda Lucas , Silva Aline Cerqueira Santos Santana da , Silva Liliane Faria da , França Luiz Carlos Moraes
Published: August 2021

Objetivo: relatar a experiência de utilização do software Interface de R pour les Analyses Multidimensionnelles de Textes et de Questionnaires (IRAMUTEQ) como ferramenta informatizada de apoio à análise de dados textuais em uma pesquisa qualitativa em saúde. Método: tratou-se do relato de experiência acontecida entre março e junho de 2019, a partir de uma pesquisa qualitativa desenvolvida por meio do Método Criativo-Sensível e com o uso do IRAMUTEQ. Participaram puérperas e familiares de recém-nascidos de uma instituição hospitalar pública localizada na cidade de Rio das Ostras no Estado do Rio de Janeiro, Brasil. Resultados: foi possível constatar que as diferentes técnicas de análise lexical disponíveis no IRAMUTEQ permitiram discriminar, claramente, os conteúdos semânticos referentes às pretensões dos cuidadores sobre os cuidados a serem desempenhados com o recém-nascido em casa. Conclusão: essa ferramenta informatizada mostrou-se útil, adequada e fidedigna, qualificando o processo de análise textual.
Determinantes sociais como caminho para promover saúde no pré-natal: percepção dos profissionais da atenção primária
Authors: Rocha Carolina Gabriele Gomes da , Heidemann Ivonete Teresinha Schulter Buss , Souza Jeane Barros de , Durand Michelle Kuntz , Maciel Kamila Soares , Backes Marli Terezinha Stein
Published: August 2021

Objetivo: compreender a percepção dos profissionais da atenção primária acerca da influência dos determinantes sociais na promoção da saúde das gestantes no pré-natal. Método: estudo qualitativo, tipo ação participante, fundamentado no Itinerário de Pesquisa de Paulo Freire, desenvolvido por meio da Investigação Temática, Codificação e Descodificação e o Desvelamento Crítico, que consiste na análise dos dados. Realizaram-se dois Círculos de Cultura em uma Unidade de Saúde, entre julho e outubro de 2019, com 18 profissionais da saúde. Resultados: investigaram-se dois temas: um reflete os determinantes envolvidos no pré-natal; e o outro, discute o cuidado no pré-natal e os determinantes como caminho para promover saúde. Desvelaram a relevância de conhecer os determinantes envolvidos no cotidiano das gestantes e que devem ser considerados integralmente. Conclusão: são múltiplas as barreiras enfrentadas pelas gestantes no pré-natal, sendo necessário o seu fortalecimento com cuidados promotores de saúde e articulado aos determinantes sociais.
Produção de aventais descartáveis em complexo prisional: ação de enfermagem no enfrentamento à COVID-19
Authors: Silva George Oliveira , Ues Larissa Viana , Hoelzel Carlos Gustavo Martins , Neves Heliny Carneiro Cunha , Mendonça Katiane Martins , Ribeiro Luana Cássia Miranda
Published: August 2021

Objetivo: compartilhar a experiência relacionada à produção de aventais descartáveis conduzida pela enfermagem em complexo prisional no contexto da pandemia da COVID-19. Método: relato de experiência das ações de extensão de projeto de produção de equipamentos de proteção individual realizadas em complexo prisional da região Centro-Oeste do Brasil, no período de março a junho de 2020. Resultados: foram produzidos 6.000 aventais, adotando as normas da Associação Brasileira de Normas Técnicas. No processo, houve aprendizado das medidas de higiene e limpeza para prevenção da COVID-19, com destaque para a higienização das mãos, readequação de fluxo e do ambiente de produção. Conclusão: a experiência pautou-se no compromisso social da universidade pública e foi oportunidade ímpar de desenvolvimento de conhecimentos e habilidades, bem como de reeducação e ressocialização dessa população. Além disso, reforçou o papel da enfermagem no enfrentamento de agravos de saúde pública.
Music Therapy in Enhancing Learning Attention of Children with Intellectual Disability
Authors: Dada Akintunde Oluseyi , Adeleke Owoade Philip , Aderibigbe Samson Akinwumi , Adefemi Michael Adeife , Apie Martina Ayibeya
Published: August 2021

Inattention is one of the significant problems that inhibit learning among children with intellectual disabilities. However, several strategies and therapies have been developed to solve the problem. This study, therefore, investigates the effectiveness of music therapy in enhancing attention among children with intellectual disability. A pretest-posttest control experimental research design was adopted. The experiment was carried out for six weeks using Music Therapy Treatment Package on 24 children with intellectual disability that were randomly selected Modupe Cole Momerial Childcare and Treatment Home/School, Akoka, Yaba, Lagos. A validated Attention Observation Rating Scale (AORS) with a reliability coefficient of 0.88 was used for this study. Three hypotheses were tested in the study, and Analysis of Covariance (ANCOVA) was used for data analysis. This study revealed that music therapy is effective in enhancing attention among children with intellectual disabilities. Sex and level of severity of the disability were also tested as moderator variables, but they have no significant main or interaction effect with music therapy in enhancing attention for children with intellectual disability. The finding is that music therapy is significantly effective in enhancing attention for children with intellectual disability regardless of their sex or level of severity. It was concluded that attention deficit could be improved for children with intellectual disability. Therefore, Music therapy was recommended for use in the school with adequate teacher training.
Social Networking Addiction and Quality of Academic Life among First-Year High School Students in Saudi Arabia: The Mediating Role of Academic Procrastination
Authors: Khalifa Ayman Gamal
Published: August 2021

Students with high levels of procrastination were unable to organize and achieve their academic goals. A student who procrastinates may face internal consequences such as low academic performance, bad learning habits, and low learning motivation. When he/she is unable to address procrastination, this will hinder his/her academic performance. The study group of the research consists of 258 boys studying in high schools in the Riyadh region in the 2019-2020 academic year. They aged 16-18 years, (M= 17.23,SD= 4.45). Social Media Addiction Scale - Student Form, High-School Satisfaction Scale, and Tuckman's procrastination scale –short form were used for gathering and analyzing data. Quality of academic life correlates negatively with social networking addiction and academic procrastination.

On the other hand, social networking addiction was found to be positively correlated with academic procrastination. Regression coefficients of the empirical model show that social networking addiction had a direct negative effect on the quality of academic life (b= -0.49, p<0.001) and a direct positive effect on academic procrastination (b=0.52, p<0.001). Results support previous research showing that social networking addiction negatively impacts academic achievement by creating academic procrastination, reducing sleep quality, and increasing academic stress. Evidence indicates a positive and significant correlation between inappropriate and problematic use of technology and quality of academic life. Procrastination may interrupt the academic performance, as procrastinators are likely to avoid completing the task at Hand until the last moment. They may also be unable to invest the time and effort necessary for performing as they underestimate the amount of time required for completing specific tasks.
Dynamic Plasticity Model for Rapidly Heated 1045 Steel Up to 1000°C
Authors: Mates Steven P. , Li Sheng-Yen
Published: August 2021

The National Institute of Standards and Technology (NIST) developed an
experimental technique to measure the dynamic flow stress of metals under rapid heating
to study their time-dependent plastic response when heating times are short enough to
interrupt or bypass thermally driven microstructural evolution. Such conditions may
exist as chips are formed in the machining process. Measurements of American Iron and
Steel Institute1045 steel behavior up to 1000 °C showed complex thermal softening due to
dynamic strain aging effects and the diffusion-limited austenite transformation process
beginning at the A1 temperature (712 °C). This paper proposes a constitutive model to
capture the flow stress and hardening evolution of 1045 steel under rapidly heated
conditions for simulating metal cutting. The model combines the Preston-Tonks-Wallace
plasticity model, which uses five parameters to capture complex rate- and
temperature-sensitive strain hardening, with a dual-rate-sensitivity model to capture
the response of rapidly heated 1045 steel. Finally, a strain-rate-dependent Gaussian
function is introduced to capture dynamic strain aging effects, which act over a narrow
range of temperatures that change with strain rate. The proposed model is compared to
existing plasticity models for 1045 steel over the range of data available and at a
representative machining condition.
A formação ética e o autoconhecimento para a formação de professores(as) em direitos humanos e ciências naturais
Authors: Correia Cruz Bonfim Hanslivian , Guimarães Orliney Maciel
Published: August 2021

Este ensaio teórico tem como objetivo discutir sobre a formação continuada de professores(as) de Ciências Naturais, dos anos iniciais do ensino fundamental, voltada à formação ética e ao autoconhecimento, tendo como propósito uma Educação em Direitos Humanos. Para o desenvolvimento deste ensaio, foi realizado um levantamentobibliográfico em livros, periódicos acadêmicos e artigos, que teve como objetivo aprofundar a temática apontada. Considera-se que as atitudes pedagógicas dos(as) professores(as) podem ser influenciadas pelas disposições construídas ao longo de sua história, assim é importante que o(a) docente reflita sobre essas disposições (habitus), visando uma formação ética, política e crítica, que leva ao desenvolvimento de práticaspedagógicas mais voltadas para uma Educação em Direitos Humanos.
Autoconhecimento como estratégia formativa do professor
Authors: Gouvêa Lousada Marcia , Barreto Maribel Oliveira
Published: August 2021

Diante da modificação ocorrida na Base Nacional Comum Curricular (BNCC), pela qual espera-se que o professor desenvolva competências em seus estudantes, as quais englobem uma formação humana e ética, além da formação técnica e com especial relevância para o autoconhecimento e autocuidado, mostra-se necessário compreendercomo os autores da área realizam tal desenvolvimento. Para tanto foram analisados 22 resumos de artigos, dissertações e teses publicadas entre 2015 e 2020 nas plataformas do Educ@ e da Biblioteca Digital Brasileira de Teses e Dissertações (BDTD) a fim de conhecer as técnicas empregadas na promoção de tal capacidade e/ou habilidade. Comoresultado encontraram-se tentativas de agregar a compreensão intrapsíquica na educação, sendo utilizadas diversas estratégias que vão desde a simples reflexão sobre si e a conscientização das escolhas realizadas e a realizar até a combinação de técnicas e teorias da Psicologia, muitas vezes já utilizadas no mundo corporativo. Outra tendência manifestada nesta investigação foi a inclusão de uma visão mais abrangente de Ser Humano, a necessidade e importância de uma visão holística, de um Ser Humano Integral que possibilite abarcar um trabalho que atue com as dimensões físico/corporal, afetivo/emocional, cognitivo/mental, social e espiritual/transcendente.
Educação inclusiva: diferentes configurações, olhares e mundos possíveis
Authors: Conte Elaine , Habowski Adilson Cristiano
Published: August 2021

Nos últimos anos surgiram muitos debates sobre o assunto da inclusão em sala de aula e as dificuldades geradas pela falta de reconhecimento da contribuição pedagógica à formação da pessoa com deficiência associadas a inseguranças, referências de projetos interdisciplinares robustos para contextualizar as desigualdades. Entretanto, no cenário educativo, o que se vê é uma intensa precariedade do ensino público e a omissão dos diversos setores da sociedade que não pensam estratégias articuladoras e integradoras para superar essas problemáticas vitais. Assim, este estudo tem por objetivo realizar uma análise sobre os entraves à atividade do professor em relação à inclusão de crianças com necessidades especiais em sala de aula, a partir de uma revisão de literatura e de um questionário de perguntas abertas, por meio de recursos Google Forms, respondido por cinco professoras que atuam no campo da Educação Inclusiva dos anos iniciais de Educação Básica. Os resultados apontam dificuldades dos educadores nos processos inclusivos à criação de atividades pedagógicas, por inexperiência com o campo na formação acadêmica e ausência de recursos disponíveis nas escolas para dar conta da proposta de inclusão de todos, cujo valor motivacional para o aprender dos estudantes centra-se nas proposições criativas e investigativas do professor. Ficam evidentes grandes entraves formativos, pois as cinco professoras em atuação, que responderam ao questionário, não possuem formação específica para atuar com crianças deficientes.
Formação continuada de professores ao incluir aluno surdo no ensino superior: relato de experiências
Authors: Richartz Terezinha , Lemes de Oliveira Thiago
Published: August 2021

Em uma sociedade diversificada e cada vez mais preocupada com a equidade humana, compete ao professor uma atualização constante de seus conhecimentos, e consequentemente, ressignificação didática. Objetiva-se, neste artigo, portanto, discutir a importância da formação continuada de professores face à inclusão de um aluno surdo em sala de aula, em um curso de Pedagogia no interior de Minas Gerais, bem como, apresentar o gênero autobiográfico para se conhecer o contexto histórico do discente no intuito de identificar e desenvolver metodologias que promovam sua interação e mediação. Destina-se, ainda, relatar a experiência vivenciada por todos os sujeitos envolvidos na busca de alternativas de mediação, ensino, avaliação e por último, descrever as adaptações realizadas para respeitar a singularidade linguística do discente Surdo. A partir dessa perspectiva, o referencial teórico se pauta em autores como, Frison; Simão, Oliveira, Nacarato, Nóvoa e Foucault. A metodologia utilizada configura o relato de experiência associada à autobiografia de um aluno Surdo. Como resultado, observa-se que a formação continuada, atrelada ao trabalho em conjunto de professores e tradutor e intérprete de Libras, foi fundamental para entender demandas apresentadas a partir da especificidade do aluno surdo, além de compartilhar ações práticas e vivências de seus participantes durante esse processo.
A narratividade na formação continuada de professores para uma educação inclusiva
Authors: De Oliveira Evangelista Lanuti José Eduardo , Sampaio Dias Baptista Maria Isabel
Published: August 2021

A partir de um estudo bibliográfico, analisaram-se os itinerários e resultados de duas pesquisas de Doutorado, defendidas em 2018 e 2019 no Laboratório de Estudos e Pesquisas em Ensino e Diferença (LEPED), da Universidade Estadual de Campinas (UNICAMP). A necessidade de encontrar caminhos que possibilitam uma formação continuada de professores para uma educação inclusiva originou essas investigações. Sabe-se que a formação inicial não é suficiente para preparar os professores para o desenvolvimento de um trabalho pedagógico inclusivo, uma vez que as demandas, nesse sentido, se atualizam constantemente. Assim sendo, os objetivos deste texto foram analisar as contribuições da valorização da narratividade dos professores participantes de dois processos de formação continuada, um presencial e outro à distância, e identificar quais os pontos em comum entre os dois processos que levaram os participantes a uma reflexão e reconstrução de práticas pedagógicas a fim de incluir todos os estudantes na sala de aula comum. Concluiu-se que, em ambas as teses, a valorização da subjetividade dos professores participantes e o fundamento na Política Nacional de Educação Especial na Perspectiva da Educação Inclusiva (PNEEPEI, BRASIL, 2008) foram pontos determinantes para o entendimento dos professores sobre o que é a inclusão e suas demandas. Ao narrarem as suas experiências docentes durante as duas formações investigadas, os participantes repensaram o modo como concebiam o ensino, a aprendizagem e a deficiência e entenderam que o papel de uma escola inclusiva é o de promover a plena participação de cada aluno, mas segundo a sua capacidade, sem a pretensão de que ocorra uma homogeneização da aprendizagem.
Memórias e narrativas dos estudantes da educação do campo mediadas pelo caderno da realidade
Authors: Gerke Janinha , Guimarães Alessandro Da Silva
Published: August 2021

Este texto nasce no seio das experiências formativas empreendidas na Licenciatura em Educação do Campo, da Universidade Federal do Espírito Santo, no campus de Goiabeiras/Vitória, ES. Tem como objetivo dialogar com as memórias e narrativas dos sujeitos em formação, registradas nos Cadernos da Realidade, buscando à luz destas conhecer, reconhecer e compreender os processos enredados. Investiga como o uso desses cadernos tem potencializado as aprendizagens construídas nos territórios formativos do tempo universidade e do tempo comunidade. Fundamenta-se nos estudos de Walter Benjamin (1996), em especial nas discussões sobre experiência, e produz interlocuções teóricas com autores que caminham com o Movimento Nacional da Educação do Campo e a Formação por Alternância. Como perspectiva metodológica, analisa narrativas e memórias registradas nos Cadernos da Realidade a partir das discussões de Josso (2004) e Bertaux (2010). Compreende que os Cadernos podem ser empregados como mediações didático-pedagógicas da formação por alternância, capazes de propulsarem o pensar reflexivo e problematizador da inserção comunitária dos estudantes, do desenvolvimento profissional docente no campo e, ainda, da própria trajetória dos sujeitos na licenciatura em Educação do Campo.
Narrativas de professores ribeirinhos: tensões, fragilidades e desafios
Authors: Nauar de Almeida Edwana , De Moraes Braga Bassalo Lucelia
Published: August 2021

No contexto educacional amazônico ribeirinho, chama atenção a atuação das professoras e dos professores diante das condições e peculiaridades que atravessam seu cotidiano de trabalho pedagógico. Se fazem presentes as dimensões atitudinais e éticas uma vez que a experiência da docência se constrói lado a lado com os e as estudantes numa tessitura de sentidos subjetivos sobre a escola, sobre o ato de ensinar, sobre as responsabilidades educativas de cada um dos envolvidos nesse processo. O artigo apresenta, a partir de narrativas de professores ribeirinhos, a discussão de um dos aspectos mais objetivos, mas não tão claros da atividade pedagógica: as percepções sobre os e as estudantes e os modos de lidar com os desafios que lhes são impostos e que atravessam o fazer docente. A pesquisa orientou-se pela abordagem qualitativa, reunindo narrativas de três professores/as da rede pública de ensino em municípios ribeirinhos do Estado do Pará. A análise foi realizada tendo em vista os pressupostos da análise de narrativa segundo Fritz Schütze (2013). Os resultados de análise das narrativas apontam para a premência da circulação de significados tradicionais acerca da formação e papel da família, frustrações com a falta de condições objetivas para a realização do trabalho docente, fragilidade da formação dos professores para entender e lidar com a precariedade que marcam a trajetória de vida dos estudantes.
Entre ser “a pessoa mais importante do lugar” e “apenas um professor”
Authors: Aparecida Fernandes Moutinho Gomes Valdete , Nunes Célia Maria Fernandes , Pádua Karla Cunha
Published: August 2021

Neste artigo, discutimos a influência do contexto sociocultural em que a escola está inserida para a percepção de valorização docente conforme a narrativa de uma professora do ensino fundamental I. As reflexões ora apresentadas desenvolveram-se durante uma pesquisa que procurou investigar a valorização docente na narrativa de uma professora dos anos iniciais do ensino fundamental, que atua na rede municipal da cidade de Mariana, Minas Gerais. Como procedimentos metodológicos, desenvolvemos um levantamento bibliográfico acerca da valorização docente para compreendermos como a questão tem sido discutida pela literatura da área e contemplada pela legislação. Além disso, realizamos a entrevista narrativa, cujos achados evidenciaram que a valorização docente ultrapassa a dimensão objetiva (condições de trabalho e carreira, formação e remuneração), privilegiada nos estudos do campo. A pesquisa demonstrou a importância da dimensão subjetiva para a valorização, incluindo assim, as interações humanas vivenciadas no exercício da profissão e a percepção de reconhecimento social. Nesta direção, apresentamos os fatos mais marcantes da trajetória profissional da professora pesquisada e analisamos as suas percepções acerca do exercício da docência em uma escola do campo e em uma escola da periferia da cidade de Mariana-MG, procurando compreender como o contexto sociocultural influencia a percepção de valorização docente.
Apical contacts stemming from incomplete delamination guide progenitor cell allocation through a dragging mechanism
Authors: Pulgar Eduardo , Schwayer Cornelia , Guerrero Néstor , López Loreto , Márquez Susana , Härtel Steffen , Soto Rodrigo , Heisenberg Carl-Philipp , Concha Miguel L
Published: August 2021

The developmental strategies used by progenitor cells to allow a safe journey from their induction place towards the site of terminal differentiation are still poorly understood. Here, we uncovered a mechanism of progenitor cell allocation that stems from an incomplete process of epithelial delamination that allows progenitors to coordinate their movement with adjacent extra-embryonic tissues. Progenitors of the zebrafish laterality organ originate from the superficial epithelial enveloping layer by an apical constriction process of cell delamination. During this process, progenitors retain long-lasting apical contacts that enable the epithelial layer to pull a subset of progenitors on their way to the vegetal pole. The remaining delaminated cells follow the movement of apically attached progenitors by a protrusion-dependent cell-cell contact mechanism, avoiding sequestration by the adjacent endoderm, ensuring their collective fate and allocation at the site of differentiation. Thus, we reveal that incomplete delamination serves as a cellular platform for coordinated tissue movements during development.
MACF1 controls skeletal muscle function through the microtubule-dependent localization of extra-synaptic myonuclei and mitochondria biogenesis
Authors: Ghasemizadeh Alireza , Christin Emilie , Guiraud Alexandre , Couturier Nathalie , Abitbol Marie , Risson Valerie , Girard Emmanuelle , Jagla Christophe , Soler Cedric , Laddada Lilia , Sanchez Colline , Jaque-Fernandez Francisco-Ignacio , Jacquemond Vincent , Thomas Jean-Luc , Lanfranchi Marine , Courchet Julien , Gondin Julien , Schaeffer Laurent , Gache Vincent
Published: August 2021

Skeletal muscles are composed of hundreds of multinucleated muscle fibers (myofibers) whose myonuclei are regularly positioned all along the myofiber’s periphery except the few ones clustered underneath the neuromuscular junction (NMJ) at the synaptic zone. This precise myonuclei organization is altered in different types of muscle disease, including centronuclear myopathies (CNMs). However, the molecular machinery regulating myonuclei position and organization in mature myofibers remains largely unknown. Conversely, it is also unclear how peripheral myonuclei positioning is lost in the related muscle diseases. Here, we describe the microtubule-associated protein, MACF1, as an essential and evolutionary conserved regulator of myonuclei positioning and maintenance, in cultured mammalian myotubes, in Drosophila muscle, and in adult mammalian muscle using a conditional muscle-specific knockout mouse model. In vitro, we show that MACF1 controls microtubules dynamics and contributes to microtubule stabilization during myofiber’s maturation. In addition, we demonstrate that MACF1 regulates the microtubules density specifically around myonuclei, and, as a consequence, governs myonuclei motion. Our in vivo studies show that MACF1 deficiency is associated with alteration of extra-synaptic myonuclei positioning and microtubules network organization, both preceding NMJ fragmentation. Accordingly, MACF1 deficiency results in reduced muscle excitability and disorganized triads, leaving voltage-activated sarcoplasmic reticulum Ca2+ release and maximal muscle force unchanged. Finally, adult MACF1-KO mice present an improved resistance to fatigue correlated with a strong increase in mitochondria biogenesis.
Anti-clustering in the national SARS-CoV-2 daily infection counts
Authors: Roukema Boudewijn F.
Published: August 2021

The noise in daily infection counts of an epidemic should be super-Poissonian due to intrinsic epidemiological and administrative clustering. Here, we use this clustering to classify the official national SARS-CoV-2 daily infection counts and check for infection counts that are unusually anti-clustered. We adopt a one-parameter model of $\phi _i^{\prime}$ infections per cluster, dividing any daily count ni into $n_i/ _i^{\prime}$ ‘clusters’, for ‘country’ i. We assume that ${n_i}/\phi _i^{\prime}$ on a given day j is drawn from a Poisson distribution whose mean is robustly estimated from the four neighbouring days, and calculate the inferred Poisson probability $P_{ij}^{\prime}$ of the observation. The $P_{ij}^{\prime}$ values should be uniformly distributed. We find the value $\phi_i$ that minimises the Kolmogorov–Smirnov distance from a uniform distribution. We investigate the (ϕi, Ni) distribution, for total infection count Ni. We consider consecutive count sequences above a threshold of 50 daily infections. We find that most of the daily infection count sequences are inconsistent with a Poissonian model. Most are found to be consistent with the ϕi model. The 28-, 14- and 7-day least noisy sequences for several countries are best modelled as sub-Poissonian, suggesting a distinct epidemiological family. The 28-day least noisy sequence of Algeria has a preferred model that is strongly sub-Poissonian, with $\phi _i^{28} < 0.1$. Tajikistan, Turkey, Russia, Belarus, Albania, United Arab Emirates and Nicaragua have preferred models that are also sub-Poissonian, with $\phi _i^{28} < 0.5$. A statistically significant (Pτ < 0.05) correlation was found between the lack of media freedom in a country, as represented by a high Reporters sans frontieres Press Freedom Index (PFI2020), and the lack of statistical noise in the country’s daily counts. The ϕi model appears to be an effective detector of suspiciously low statistical noise in the national SARS-CoV-2 daily infection counts.
Genetic diversity and structure of one of the most endangered freshwater fish species in Mexico:Tlaloc hildebrandi(Miller, 1950) and recognition of its evolutionarily significant units
Authors: Beltrán-López Rosa G. , González-Díaz Alfonso A. , Soria-Barreto Miriam , Garduño-Sánchez Marco Antonio , Xochitla-Castrejón Carmela , Rodiles-Hernández Rocío , Ornelas-García Claudia Patricia
Published: August 2021

The endangered Chiapas killifishTlaloc hildebrandiis an endemic freshwater species that lives in four subbasins of the Grijalva and Usumacinta basins, and one of the most geographically restricted species of the Produndulidae family. The species was originally described as endemic to springs in the high limestone plateau in San Cristóbal de Las Casas in the Río Amarillo subbasin (upper Grijalva basin). However, it was recently recorded in the Jataté and Tzaconejá subbasins in the upper Usumacinta basin, thereby expanding its known distribution range. The discovery of these populations is relevant not only for the conservation of the species but also for a better understanding of its evolutionary history. Currently, the scarce populations ofT. hildebrandi, found in only a few localities in the Grijalva and Usumacinta basins, are fragmented and living under unfavorable conditions. Here, we analyzed three mitochondrial (mt-atp8&6andmt-nd2) and one nuclear (nuc-s7) marker in order to assess the genetic diversity and population structure ofT. hildebrandi. We found that, in comparison with other endangered freshwater fish species from Mexico,T. hildebrandishowed a lower level of genetic diversity (mt-nd2:h= 0.469,π= 0.0009;mt-atp8&6:h= 0.398,π= 0.001; andnuc-S7:h= 0.433,π= 0.001). Moreover, the analyzed populations exhibited a strong genetic structure in accordance with their geographic distribution, and can be placed into three genetic clusters: (1) Amarillo plus Chenhaló in the upper Grijalva basin, (2) Jataté, and (3) Tzaconejá, both in the upper Usumacinta basin. On the basis of our results, we propose the recognition of at least three evolutionarily significant units (ESUs) for the species and the urgent implementation ofex situandin situconservation and management efforts that consider the genetic background of the species.
Low winter precipitation, but not warm autumns and springs, threatens mountain butterflies in middle-high mountains
Authors: Konvicka Martin , Kuras Tomas , Liparova Jana , Slezak Vit , Horázná Dita , Klečka Jan , Kleckova Irena
Published: August 2021

Low-elevation mountains represent unique model systems to study species endangered by climate warming, such as subalpine and alpine species of butterflies. We aimed to test the effect of climate variables experienced byErebiabutterflies during their development on adult abundances and phenology, targeting the key climate factors determining the population dynamics of mountain insects. We analysed data from a long-term monitoring of adults of two subalpine and alpine butterfly species,Erebia epiphronandE. sudetica(Nymphalidae: Satyrinae) in the Jeseník Mts and Krkonoše Mts (Czech Republic). Our data revealed consistent patterns in their responses to climatic conditions. Lower precipitation (i.e., less snow cover) experienced by overwintering larvae decreases subsequent adult abundances. Conversely, warmer autumns and warmer and drier springs during the active larval phase increase adult abundances and lead to earlier onset and extended duration of the flight season. The population trends of these mountain butterflies are stable or even increasing. On the background of generally increasing temperatures within the mountain ranges, population stability indicates dynamic equilibrium of positive and detrimental consequences of climate warming among different life history stages. These contradictory effects warn against simplistic predictions of climate change consequences on mountain species based only on predicted increases in average temperature. Microclimate variability may facilitate the survival of mountain insect populations, however the availability of suitable habitats will strongly depend on the management of mountain grasslands.
Stereotyped whistles in southern resident killer whales
Authors: Souhaut Marie , Shields Monika W.
Published: August 2021

The endangered Southern Resident killer whales (Orcinus orca) of the northeast Pacific region use two main types of vocal signals to communicate: discrete calls and whistles. Despite being one of the most-studied cetacean populations in the world, whistles have not been as heavily analyzed due to their relatively low occurrence compared to discrete calls. The aim of the current study is to further investigate the whistle repertoire and characteristics of the Southern Resident killer whale population. Acoustic data were collected between 2006–2007 and 2015–2017 in the waters around San Juan Island, Washington State, USA from boats and from shore. A total of 228 whistles were extracted and analyzed with 53.5% of them found to be stereotyped. Three of the four stereotyped whistles identified by a previous study using recordings from 1979–1982 were still occurring, demonstrating that whistles are stable vocalizations for a period of more than 35 years. The presence of three new stereotyped whistles was also documented. These results demonstrate that whistles share the longevity and vocal tradition of discrete calls, and warrant further study as a key element of Southern Resident killer whale communication and cultural transmission.
Effects of Changing Anticoagulation with Unfractionated Heparin into Enoxaparin in Hemodialysis Patients:Prospective Non Randomized Unicentre Study
Authors: Megahed Abir Farouk , Tawfik Mona , Hles Ghassoub Mustafa , Alsheikh Hiba Ibrahim Ali , Sayed-Ahmed Nagy
Published: August 2021

Background: Maintaining the patency of the extracorporeal circuit (ECC) is required. The cost and long-term effect of anticoagulants on hemodialysis (HD) patients' parameters are still matters of concern. We aimed to study the effect of shifting to enoxaparin instead of unfractionated heparin (UFH) during HD and evaluate its efficacy, safety, and benefits.

Design and methodology: This study was conducted at Arar hospital, Kingdom of Saudi Arabia (KSA), and included 86 end-stage renal disease (ESRD) patients on HD for six months starting from October 2017. All patients had been on UFH as an anticoagulant during hemodialysis sessions before they were shifted to equivalent doses of enoxaparin sodium (Clexan®) as a therapeutic upgrade to start with. The patients’ files were examined retrospectively for the period of UFH therapy and then all patients were observed prospectively for at least 6 months while on Clexane. The occurrence of clotting in the dialysis sets were recorded and the need for urgent HD for each patient and the reasons. 

Results: There was a reduction of filter clots even with the reduction of enoxaparin dose. There was a significant reduction of mean cholesterol, calcium, phosphorus, sodium, chloride, and serum osmolality. We found a significant reduction of pre-dialysis potassium among those who presented with a pre-dialysis potassium of higher than 5.5 mg/dl during the enoxaparin phase. Patients, who had thrombocytopenia while on UFH; showed improvement in platelet count after the shift to enoxaparin. However, patients who had platelet count lowered than 150000/mm3 6 months after having been shifted to enoxaparin; many of them received HD through a permanent catheter. No patients had a three-fold increase of normal values (3ULN) of liver function tests whether being on heparin or enoxaparin.

Conclusion: Low molecular weight heparin (LMWH) could be more efficacious and safe than UFH with the improvement of some variables in HD patients.
Maximum Product of Spacing Parameter Estimation of Gompertz Rayleigh Distribution and Application to Rainfall Datasets
Authors: Abdulsalam Hussein Ahmad , Bashiru Sule Omeiza , Isa Alhaji Modu , Ojirobe Yunusa Adavi
Published: August 2021

Gompertz Rayleigh (GomR) distribution was introduced in an earlier study with few statistical properties derived and parameters estimated using only the most common traditional method, Maximum Likelihood Estimation (MLE). This paper aimed at deriving more statistical properties of the GomR distribution, estimating the three unknown parameters via a competitive method, Maximum Product of Spacing (MPS) and evaluating goodness of fit using rainfall data sets from Nigeria, Malaysia and Argentina.

Properties of statistical distributions including distribution of smallest and largest order statistics, cumulative or integrated hazard function, odds function, rth non-central moments, moment generating function, mean, variance and entropy measures for GomR distribution were explicitly derived. The fitted data sets reveal the flexibility of GomR distribution over other distributions been compared with. Simulation study was used to evaluate the consistency, accuracy and unbiasedness of the GomR distribution parameter estimates obtained from the method of MPS. The study found that GomR distribution could not provide a better fit for Argentine rainfall data but it was the best distribution for the rainfall data sets from Nigeria and Malaysia in comparison with the distributions; Generalized Weibull Rayleigh (GWR), Exponentiated Weibull Rayleigh (EWR), Type (II) Topp Leone Generalized Inverse Rayleigh (TIITLGIR), Kumarawamy Exponential Inverse Raylrigh (KEIR), Negative Binomial Marshall-Olkin Rayleigh (NBMOR) and Exponentiated Weibull (EW). Furthermore, the estimates from MPSE were consistent as the sample size increases but not as efficient as those from MLE.
Effect of Seed Rates and Weeding Frequency on Yield and Yield Components of Bread Wheat (Triticum aestivum L.) on Vertisols in Toke Kutaye District
Authors: Hunde Gudina Soboksa , Ashagre Habtamu , Abraham Thomas
Published: August 2021

Bread wheat (Triticum aestivum L.) plays a crucial role in ensuring food security in Ethiopia. However, its production and productivity is constrained by weed infestation and inappropriate seed rate used. Hence, an experiment was conducted to determine the optimal seed rate and weeding frequency for bread wheat production on Vertisols in Toke Kutaye district during 2020 main cropping season. Treatments consisted of five levels of seed rates (75, 100, 125, 150, and 175kgha-1) and four levels of weeding frequency (zero weeding, once weeding (15DAE), twice weeding (15 and 45 DAE) and thrice weeding (15, 45 and 75 DAE). Experiment was laid out in Randomized Complete Block Design (RCBD) with factorial combination replicated thrice. Results of the study revealed that the interaction of seed rate and weeding frequency significantly (P≤ 0.05) influenced phenological and growth parameters except days reqired for 50% emergence and yield of bread wheat. Highest wheat biomass yield (11.03tha-1), grain yield (4.47tha-1) and straw yield (6.6tha-1)were obtained using 175kgha-1seed rate with thrice hand weeding. Highest relative yield loss (71.3%) was recorded from weedy plot with 75kgha-1seed rate, while the lowest loss (1.2%) was recorded at 175kgha-1seed rate with thrice hand weeding. Highest net benefit of ETB 73,170ha-1 , marginal rate of return 884.4% and value to cost ratio of ETB 8.34 per unit of investment was obtained from 175kgha-1 seed rate combined with thrice hand weeding. Therefore, use of 175kgha-1 seed rate with thrice hand weeding was found profitable, and recommended for bread wheat production in Toke Kutaye district.
Comparative Profitability and Impact of BINA Developed Aman Mutant Rice Binadhan-7 with Non-Mutant Variety in Bangladesh
Authors: Rahman M. H. , Sultana R. , Sarkar M. M. A. , Islam S. , Azad M. A. K. , Sivasankar S.
Published: August 2021

This papar examined the cost and revenue as well as impact of mutant rice on fourteen region of Bangladesh namely Mymensingh, Jashore, Cumilla, Bogura, Rajshahi, Sylhet, Dinajpur, Rangpur, Dhaka, Khulna, Chattagram, Rangamati, Barishal and Faridpur. A total of 560 farmers were randomly selected to fulfill the objectives where 280 farmers were mutant growers and 280 were non- mutant growers. A pre-designed interview schedule was used to collect the necessary data. Descriptive statistics, profit function and livelihood assets were used to analyzed the collected data. The study revealed that total variable cost of rice cultivation was BDT.40589 and BDT.43927 per hectare for mutant and non mutant, respectively which was around 71 percent of total cost of production. On an average, the total cost of production was BDT.59584 per hectare, where 29 percent was fixed costs and 71 percent was variable cost. For Binadhan-7 cultivation per hectare average net return was found highest in Dinajpur region i.e. BDT.70919 and the lowest in Jashore region i.e. BDT.33703. BCR on total cost basis was found 1.90 which was the highest in Sylhet 2.56 and the lowest 1.51 in Jashore region for Binadhan-7 production. In case of non-growers BCR on total cost basis was found 1.43 which was lower than Binadhan-7 production in the study areas indicating Binadhan-7 growers earn much than the non growers. The asset pentagon approach showed that there is a noteworthy increases in capitals of sampled farm households and the highest for financial capital that was 20.05 percent and the lowest was for natural capital i. e., 5.38 percent. Among the list of preferences, the highest was 88.93 percent for short duration and it was ranked I, the lowest was high yielding i.e. 81.43 percent which was ranked as V. Among the constraints, the highest constraint reported by the farmer was labour crisis as well as high price of labour i.e. 80.71 percent and it was ranked I and the lowest ranked V was lack of quality seed at proper time i.e. 48.93 percent in Binadhan-7 cultivation. Finally it is remarked that short duration high yielding variety Binadhan-7 plays a vital role in the monga mitigation of the northern areas of Bangladesh.