bluuebunny/crossref_metadata_2025 huggingface dataset:
Interactions between root hairs and the soil microbial community affect the growth of maize seedlings
Authors: Quattrone Amanda , Lopez‐Guerrero Martha , Yadav Pooja , Meier Michael A. , Russo Sabrina E. , Weber Karrie A.
Published: November 2023

Root hairs are considered important for rhizosphere formation, which affects root system functioning. Through interactions with soil microorganisms mediated by root exudation, root hairs may affect the phenotypes and growth of young plants. We tested this hypothesis by integrating results from two experiments: (1) a factorial greenhouse seedling experiment with Zea mays B73‐wt and its root‐hairless mutant, B73‐rth3, grown in live and autoclaved soil, quantifying 15 phenotypic traits, seven growth rates, and soil microbiomes and (2) a semi‐hydroponic system quantifying root exudation of maize genotypes. Possibly as compensation for lacking root hairs, B73‐rth3 seedlings allocated more biomass to roots and grew slower than B73‐wt seedlings in live soil, whereas B73‐wt seedlings grew slowest in autoclaved soil, suggesting root hairs can be costly and their benefits were realized with more complete soil microbial assemblages. There were substantial differences in root exudation between genotypes and in rhizosphere versus non‐rhizosphere microbiomes. The microbial taxa enriched in the presence of root hairs generally enhanced growth compared to taxa enriched in their absence. Our findings suggest the root hairs' adaptive value extends to plant‐microbe interactions mediated by root exudates, affecting plant phenotypes, and ultimately, growth.
Optimization of Three-Dimensional Blade and Variable Stators for Efficiency and Stability Enhancement of Multistage Axial Flow Compressor at Variable Speeds
Authors: Zhang Xiawen , Ju Yaping , Li Zhen , Liu Feng , Zhang Chuhua
Published: November 2023

High efficiency and wide stability at variable speeds are equally important to the design and operation of multistage axial flow compressors. However, published research works on three-dimensional design optimization of compressors are so far mainly limited to a single blade row or stage at design speed due to the curse of dimensionality. Moreover, optimization of variable inlet guide vanes (IGV)/stators for off-design operations is carried out by using a rapid but low-fidelity prediction tool and is generally independent of design optimization of blade geometry. To tackle these issues, a three-dimensional holistic design and adjustment optimization method is developed in which both three-dimensional blade geometry and variable IGV/stators are optimized simultaneously for better efficiency and stability at design and off-design conditions. Metamodel-interpreted data mining method and adaptive infilling strategy are used respectively to enhance the capability of the metamodeling and optimization. The developed method is then applied to a modern highly loaded 3.5-stage transonic axial flow compressor at both design and part-design speeds. The results show that the stall margin is extended from 8.23% to 19.65% at 70% design speed while peak efficiency is slightly improved at design speed. The flow mechanisms responsible for the efficiency enhancement at design speed are mainly associated with the reduced total pressure loss in stators as well as inter- and intra-stage loading redistribution. The stability enhancement at 70% design speed is mainly achieved by loading the front blade rows while unloading the limiting rear blade row through variable IGV/stators adjustment. The developed holistic design and adjustment optimization method with the aid of metamodel-interpreted data mining is of great application value for the design and adjustment of advanced multistage axial flow compressors.
Experimental Identification of the Full Opening Time of Pneumatic Valves
Authors: Sesmat Sylvie , Chabane Saïd , Bideaux Eric , Lejeune Hubert , Jus Yoann
Published: November 2023

Precise determination of the full opening time of ON-OFF pneumatic valves is mandatory especially when they are used as safety elements. This paper proposes a new identification method based on the time at which the tank pressure time derivative is maximum during a charge test. Assuming that the flow is still choked in the valve at least up to this time, it can be shown that this maximum coincides with the full opening. In order to fulfill this condition, a minimal volume for the tank is required according to the valve dynamics and its flow characteristics. Two other conditions have to be verified: first, a constraint on the temperature time derivative during the opening phase and second, a constraint on the temperature itself just after the full opening. It can be shown that these requirements are well met. in adiabatic and isothermal conditions. However, in the general case, i.e. when convective heat exchange is considered, the analytic expression of the admissible range of physical parameters for the experimental setup is not obvious. Simulations for different kinds of opening evolutions, time displacements and valve flow characteristics underline the interest of the method and show that limitations can be reached only in non-realistic conditions. Finally, experimental results consisting in applying the proposed method to charge tests of several volumes with two kind of valves show perspectives in using this new experimental method along reliability tests.
Real-Time Prediction of Efficient Operating Points in Quasi-Stationary Agricultural Processes With Hydraulic Implements
Authors: Kazenwadel Benjamin , Geimer Marcus
Published: November 2023

Agriculture is a critical industry that relies on the use of mobile machinery with high energy demands. Currently, the efficiency optimization of agricultural machinery is limited by the targets set by the human operator. Manual adjustments of the targets are challenging since the operator does not know the optimization strategy of the internal control systems of the machines, and therefore cannot fully exploit all degrees of freedom for efficiency optimization, including the operating speed. While some agricultural processes only require draft power, others depend on additional power transmission. Compared to the use of mechanical PTO shafts to provide energy for power-intensive functions of agricultural implements, the use of hydraulics offers the possibility of variable adjustment of the transmitted power as it is independent of the engine speed. In this paper, an algorithm for the prediction of the best operating point is proposed based on an interaction model of a machine-implement combination with the environment and a neural network for the prediction of the system efficiency. Simulations demonstrate that the system can propose advantageous operating points.
Input Coupled and Output Coupled Power Split Transmission Performance Under Comprehensive Working Conditions
Authors: Marani Pietro , Chiarabelli Damiano , Gessi Silvia , Martelli Massimo
Published: November 2023

Power Split Continuously Variable Transmissions are becoming a prominent topic, made recently popular for the extensive use of this architecture in hybrid passenger cars, even though one of the most important and well-established applications is those of agricultural tractors.

The paper will present the comparison between a current production tractor Power Split Input Coupled (IC) architecture and an Output Coupled (OC) designed and set up by the authors, both of which feature hydrostatic transmission as the variable unit. Both the IC and OC architectures will be modelled with a lumped parameter approach, representing the full vehicle and taking into account all the elements from the engine, to hydraulics, to mechanical transmission, until the wheel, including a proper electronic logic control. The models will be used to calculate and compare the power flows through the different paths of the Power Split architecture in different types of cycle.

The first class of cycles is an ideal reference condition, which imposes a constant load power, varying the output speed, and can be useful to understand the operating limits and performance of the hydraulic units and to assess the overall efficiency in a comprehensive range of operating conditions. The second class of cycles are taken from DLG-Powermix, which represent some of the most common field and on road working cycles (transport, plough, cultivator etc.). This part will be able to evaluate the energy performance and to determine the impact of hydraulic losses on overall consumption in significant working conditions, thus highlighting the higher efficiency, up to 12% better, which is obtained through the implementation of the alternative output coupled architecture.
Investigation of Lubrication Film Thickness Modeling in Speed Variable Hydraulic Drives Using Adaptive Ultrasound Reflectometry
Authors: Hansen Elias Vagn , Johansen Per
Published: November 2023

A common simplification in tribological modeling assumes negligible tribodynamics. This study investigates the usability of tribological models with this assumption to describe hydraulic speed-variable drive-type systems. The study also investigates a plug-and-play tuning strategy for adaptive ultrasound reflectometry-based lubrication thickness measurements. The investigation compares dynamic and steady-state tribological modeling approaches and adaptive ultrasound reflectometry using experimental testing of a journal bearing setup. Simulations and ultrasound reflectometry give similar results regarding system vibrations, but discrepancies occur with large changes in rotational speed. Ultrasound measurements differ from simulations in the absolute level of lubrication film thickness, likely due to a lack of accuracy and robustness. Tribological models without dynamics are from this study believed to provide substantial system information at a much lower computational cost than dynamic models. The results are however limited by the current state of ultrasound reflectometry.
Using a Novel Variable Displacement Linkage Motor to Save Fuel in a Compact Track Loader Drivetrain
Authors: Hartoyo Justinus K. , Voth John A. F. , Pozo-Palacios Jonatan , Boyce-Erickson Grey , Herrera-Perez Martin , Li Perry Y. , Van de Ven James D.
Published: November 2023

This paper explores the potential of variable displacement motors to reduce energy consumption in a compact track loader’s drivetrain. While conventional track motors are fixed displacements, variable displacement motors offer operational flexibility that enables downsizing of the drivetrain pumps and hybridization. The Variable Displacement Linkage Motor (VDLM) is specifically designed for low-speed, high-torque applications without the need for a gearbox. The linkage mechanisms and rolling element bearings offer high mechanical efficiency even at reduced displacements. A multi-cylinder prototype of the VDLM has been experimentally tested and its performance map incorporated into numerical models of various drivetrain configurations to evaluate its potential to save energy. Two modified drivetrains are considered: conventional hydrostatic transmission (HST) with pump downsizing and series hybrid configuration. By considering the optimal control of the hydrostatic drivetrain with downsized pumps and the series hybrid drivetrain through static optimization and dynamic programming, it is found that VDLM can reduce fuel consumption by 5.1% with downsizing of the HST pumps, and by 43.0% in a series-hybrid configuration.
Extended Disturbance Observer-Based Sliding Mode Fault-Tolerant Control for the Dual-Valve Hydraulic Servo System With Reduced-Order Model
Authors: Hu Huibing , Wei Jianhua , Zhang Qiang , Fang Jinhui
Published: November 2023

This paper presents an analysis of an extended disturbance observer-based fault tolerant control method for a dual-valve hydraulic servo system applied in mobile machinery. The dual-valve hydraulic servo system comprises a parallel configuration of a proportional valve and a servo valve, which act as system actuators to drive a hydraulic cylinder. In this article, the external disturbance and actuator faults are integrated together into a new lumped uncertainty term by reducing the system order in the way of introducing singular perturbation theory. Thus, an extended state disturbance observer is designed to estimate the lumped disturbance term. To tackle those serious actuator failures in view of the parallel valves and guarantee system tracking performance, a switching function index is proposed. Additionally, a sliding mode control scheme is deployed to enhance the performance of the control law by suppressing the estimated disturbance and the effects of the actuator faults. The global stability of the suggested control algorithm is proved through the Lyapunov theory. Finally, co-simulations are carried out to illustrate the effectiveness of the proposed method. The results show that the proposed fault-tolerant controller together with the extended disturbance observer, provides excellent tracking performance in the presence of external disturbance, and valve faults such as jam or failure.
Novel Approaches for the Design of a Human-Powered Hydraulic Vehicle
Authors: Guevara-Ocana Santiago , Azzam Israa , Poore Jacob R. , Solorio Jose , Garcia-Bravo Jose M. , Breidi Farid
Published: November 2023

A hydrostatic bicycle, an application of light-duty hydraulic-hybrid transmissions, is a human-powered vehicle that uses pressurized fluid to transmit power to the wheels. Unlike conventional bicycles, this vehicle offers four operating modes: boost, cruising, charging, and regenerative braking. To fulfill these features, hydraulic, mechanical, electrical, and electronic components are required, leading to a complex design task considering the power availability and physical constraints. The Fluid Power Club at Purdue University developed a virtual twin of the vehicle in a mixed-reality (MR) environment for validating the design before moving to the manufacturing and construction phases. This technology allows the coexistence of virtual objects in physical environments using computers and wearable devices. This work discusses the development of a virtual representation of the proposed hydrostatic bicycle in a MR environment after specifying its desired performance and constraints. The virtual assembly of components was deployed on a headset used by industry mentors and academic advisors to provide valuable feedback concerning the layout and manufacturing considerations. This process assisted the team in making the best decisions during the conceptual design phase, saving valuable resources by helping them visualize and collaborate effectively. MR enables visualizing fluid-powered systems and their components in 3-D, thus becoming an immersive educational and training technology.
Machine Learning for Fault Diagnosis and Operation Mode Detection in Hydraulic Cylinders
Authors: Solorio Jose A. , Garcia-Bravo Jose M.
Published: November 2023

Applications of hydraulic systems are found today in a wide variety of devices, mostly in industrial and mobile machines. When extending the life and ensuring the correct operation of these machines is critical, analytical tools that provide more accurate information about the functioning and operation of these systems must be integrated to make proactive decisions. In industrial and mobile applications, there are many sensors and methods for measuring and determining the state of process variables (e.g., flow, pressure, force). However, little has been done to implement a system that can provide users with equipment status information related to on-machine hydraulics status. Implementing artificial intelligence (AI) technology and machine learning (ML) models in hydraulic system components is presented here as a solution to the challenges many industries face today, optimizing processes and making them safer and more efficient. This research paper presents the implementation of a solution for characterizing and estimating anomalies in hydraulic cylinders, one of the most versatile and widely used components in fluid-powered systems. This work describes AI and ML models implemented to determine the operating state of cylinders and whether they function normally, in specific failure modes, or in abnormal conditions that can be predicted before a catastrophic failure occurs. The models applied demonstrated over 95% level of accuracy in predicting a malfunction of the component studied and presented in this work.
Experimental Investigation of an Innovative High-Speed External Gear Pump Prototype for Advanced Electro-Hydraulic Actuated Automotive Transmissions
Authors: Milani Massimo , Montorsi Luca , Paltrinieri Fabrizio
Published: November 2023

In this paper the main performance parameters of an innovative high-speed external gear pump have been measured and analyzed for verifying its potential use as a reliable and efficient power unit for advanced electro-hydraulic actuated, automotive transmissions. More in detail, in order to deal with extremely challenging operating conditions, mainly in terms of rotational speed and delivery pressure, this volumetric machine is equipped with both two suction and delivery ports.

Firstly, the most important hydraulic and mechanical performance parameters have been acquired and evaluated, over a wide range of rotational speeds, spanning between 500 and 7000 rpm, and for two different operating temperatures, respectively equal to 40 and 60 °C.

With the aim to demonstrate the consistency of the implemented experimental procedure, two external gear pump prototypes, with the same design geometrical features, have been tested and compared, also with equivalent measurements provided by the pump manufacturer.

All the experimental tests have been completed with the help of a custom-tailored test bench, equipped with a double Cardan joint and an overdrive, specifically designed for running the pump at high rotational speed and applying a delivery pressure of about 45 bar, very near to a typical actuation value of a modern high-performance automotive transmission.

Finally, an interesting hydraulic layout, where a fraction of the overall volumetric flow rate delivered by the pump is recirculated through the secondary suction port, has been tested and compared with the standard setup where both the suction ports are directly connected to an atmospheric pressure tank. The main performance parameters measured for the two cases are very similar and, thus, the recirculating configuration can be considered as a very promising design solution for the entire actuation system.

At the end of this thorough experimental study, it is possible to conclude that the high-speed external gear pump prototypes tested and analyzed can be considered a reliable and effective alternative hydraulic power unit for advanced high-performance electro-hydraulic actuated automotive transmissions.
A synthesis of l-(+)-quinic acid from d-(–)-quinic acid
Authors: Nguyen Johnny , Bhosale Sandeep , Bennet Andrew J.
Published: November 2023

Here, we report an efficient synthesis of l-(+)-quinic acid from the natural product d-(–)-quinic acid in a 12-step sequence. The key steps involve the kinetic controlled selective protection of a lactone intermediate and the inversion of two stereocentres: the C-3 and C-5 hydroxyl of the quinic acid core using optimized oxidation–reduction conditions.
Picroside Ⅱ attenuates neuropathic pain by regulating inflammation and spinal excitatory synaptic transmission
Authors: Duan Dongxia , Wang Lian , Feng Yueyang , Hu Daiyu , Cui Donghong
Published: November 2023

Nerve injury induced microglia activation, which released inflammatory mediators and developed neuropathic pain. Picroside Ⅱ (PⅡ) attenuated neuropathic pain by inhibiting the neuroinflammation of the spinal dorsal horn; however, how it engaged in the cross talk between microglia and neurons remained ambiguous. This study aimed to investigate PⅡ in the modulation of spinal synaptic transmission mechanisms on pain hypersensitivity in neuropathic rats. We investigated the analgesia of PⅡ in mechanical and thermal hyperalgesia using the spinal nerve ligation (SNL)-induced neuropathic pain model and formalin-induced tonic pain model, respectively. RNA sequencing and network pharmacology were employed to screen core targets and signaling pathways. Immunofluorescence staining and qPCR were performed to explore the expression level of microglia and inflammatory mediator mRNA. The whole-cell patch–clamp recordings were utilized to record miniature excitatory postsynaptic currents in excitatory synaptic transmission. Our results demonstrated that the analgesic of PⅡ was significant in both pain models, and the underlying mechanism may involve inflammatory signaling pathways. PⅡ reversed the SNL-induced overexpression of microglia and inflammatory factors. Moreover, PⅡ dose dependently inhibited excessive glutamate transmission. Thus, this study suggested that PⅡ attenuated neuropathic pain by inhibiting excitatory glutamate transmission of spinal synapses, induced by an inflammatory response on microglia.
Effects of sclerostin injection on soleus and extensor digitorum longus muscle tissue in male mice
Authors: Stoikos Joshua , Kurgan Nigel , Kottaras Steven , Fajardo Val A. , Gittings William , Klentrou Panagiota
Published: November 2023

Sclerostin, a potent inhibitor of the Wnt signaling pathway, plays a critical role in bone homeostasis. Evidence suggests that sclerostin may also be involved in crosstalk between other tissues, including muscle. This pilot study attempted to examine the effects of sclerostin on soleus and extensor digitorum longus (EDL) muscle tissue from male mice that were given continuous recombinant sclerostin injections for 4 weeks. A total of 48 10-week-old male C57BL/6J mice were assigned to be sedentary or perform 1 h treadmill running per day for 4 weeks and administered subcutaneous injections of either saline or recombinant sclerostin 5 days/week. Sclerostin injection led to a reduction in the soleus myosin heavy chain (MHC) I, MHC I/IIA, MHC IIA/X, and MHC IIB cross-sectional area ( p < 0.05) with no exercise effects on these reductions. In contrast, there were no effects of sclerostin injections or exercise on the fast-twitch EDL muscle in terms of size, MHC protein, or markers of Wnt signaling. These findings provide preliminary evidence of sclerostin’s endocrine role in muscle via decreases in myofiber cross-sectional area, which seems to be independent of fiber type but muscle type-specific. More studies, however, are needed to confirm these preliminary results.
How Flexible Is CXL's Memory Protection?
Authors: Stark Samuel W. , Markettos A. Theodore , Moore Simon W.
Published: November 2023

Replacing a sledgehammer with a scalpel.
Depletion of lncRNA MEG3 Ameliorates Imatinib‐Induced Injury of Cardiomyocytes via Regulating miR‐129‐5p/HMGB1 Axis
Authors: Tang Peng , Zhou Jinjian , Liu Huagang , Mei Shenglan , Wang Kai , Ming Hao
Published: November 2023

Imatinib is a classical targeted drug to treat chronic myeloid leukemia (CML). However, it shows cardiotoxicity, which limits its clinical application. Long noncoding RNA (lncRNA) maternally expressed gene 3 (MEG3) shows proapoptotic properties in human cells. This study is performed to investigate whether targeting MEG3 can attenuate imatinib‐mediated cardiotoxicity to cardiomyocytes. In this work, H9c2 cells were divided into four groups: control group, hypoxia group, hypoxia + imatinib, and hypoxia + imatinib + MEG3 knockdown group. MEG3 and microRNA‐129‐5p (miR‐129‐5p) expression levels were detected by the quantitative real‐time PCR (qRT‐PCR). The viability and apoptosis of H9c2 cells were then evaluated by cell counting kit‐8 (CCK‐8), flow cytometry, and TUNEL assays. The targeting relationships between MEG3 and miR‐129‐5p, between miR‐129‐5p and high‐mobility group box 1 (HMBG1), were validated by dual‐luciferase reporter assay and RNA Immunoprecipitation (RIP) assay. The protein expression level of HMGB1 was detected by western blot. It was revealed that, Imatinib‐inhibited cell viability and aggravated the apoptosis of H9c2 cells cultured in hypoxic condition, and MEG3 knockdown significantly counteracted this effect. MiR‐129‐5p was a downstream target of MEG3 and it directly targeted HMGB1, and knockdown of MEG3 inhibited HMGB1 expression in H9c2 cells. In conclusion, targeting MEG3 ameliorates imatinib‐induced injury of cardiomyocytes via regulating miR‐129‐5p/HMGB1 axis.
Arterial Hypertension and Its Consequences Are the Main Predictors of Embolic Stroke of Undetermined Source
Authors: Berdalin Alexander B. , Namestnikova Daria D. , Cherkashova Elvira A. , Golovin Denis A. , Gubskiy Ilya L. , Lelyuk Vladimir G.
Published: November 2023

Background and Purpose. Embolic stroke of undetermined source (ESUS) is a subcategory of cryptogenic stroke with high frequency of occurrence and insufficient understanding its risk factors leads to the lack of determined strategies for primary/secondary prevention. This study was aimed to identify the most prominent predictors of the ESUS and to generate the overall predictive model. Methods. We performed a hospital-based prospective cohort study with 1,317 enrolled participants. We compared patients and healthy volunteers according to the main demographic, anthropometric parameters, stroke risk factors, comorbidities, and data of clinical and instrumental examination. In order to balance the study and the control groups for age and sex, the propensity score matching was performed. In order to generate the overall predictive model, a multivariate analysis was performed using the binary logistic regression method. Results. The following predictors of ESUS were identified in current study: arterial hypertension (AH); increased heart rate and pulmonary arterial systolic pressure (PASP); the presence of conduction disturbance; the enlargement of left, right atrium, and left ventricle end-systolic length; increased intima–media thickness (IMT) in right and left common carotid artery (CCA); lowered Montreal Cognitive Assessment (MoСA) cognitive scale score; the presence of subcortical microbleeds; central brain atrophy; the larger size of third ventricle; and the higher medial temporal lobe atrophy (MTA) score. The following risk factors were included in the final predictive model: the presence of AH (

p
<
0.0005

; OR = 12.98 (95% CI: 4.53–37.21)) and PASP (

p
=
0.018

; OR = 1.13 (95% CI: 1.02–1.25)) and male sex (

p
=
0.046

; OR = 2.771 (95% CI: 1.017–7.555)). The Nagelkerke’s pseudo-R-squared value was 0.404 and the significance of the Hosmer–Lemeshow test was 0.733, which indicate the goodness of the final logistic regression model. Conclusions. We propose that AH and its consequences are the main predictors of ESUS. The results of this study emphasize the importance of AH control for primary and secondary prevention of ESUS.
Dietary Epigallocatechin-3-Gallate (EGCG) Improves Nonspecific Immune Response of Chinese Rice Field Eel (Monopterus albus)
Authors: Deng Haichao , Yue Huamei , Ruan Rui , Ye Huan , Li Zhong , Li Chuangju
Published: November 2023

Epigallocatechin-3-gallate (EGCG) has been recognized as a potential additive for aquafeeds due to its beneficial biological functions. In order to evaluate the potential application of EGCG in Chinese rice field eel (Monopterus albus), six isonitrogenous and isolipidic diets containing 0, 25, 50, 100, 200, and 400 mg/kg EGCG were formulated and were fed to Monopterus albus (M. albus) for 9 weeks. The results showed that M. albus fed diets containing 0 and 100 mg/kg EGCG presented higher weight again and specific growth rate than the other groups. Fish fed with 25, 50, and 400 mg/kg EGCG displayed lower whole-body lipid content. Serum aspartate aminotransferase (AST) concentration significantly decreased in EGCG treated groups with the exception of 100 mg/kg group. Hepatic catalase (CAT) activity and glutathione (GSH) concentration decreased as EGCG level increased while malondialdehyde (MDA) concentration showed an opposite trend. EGCG supplementation resulted in a promoted lysozyme (LZM) activity and immunoglobulin M (IgM) level in the liver of M. albus. Furthermore, transcription of three immune related genes including major histocompatibility complex (mhc-2α), hepcidin, and interleukin-8 (il-8) mRNAs was upregulated by EGCG treatment; while transcription of interleukin-6 (il-6) and nuclear factor kappa-B (nf-kb) genes was downregulated. Results also showed a linear relation between EGCG inclusion level and parameters of AST, CAT, GSH, MDA, LZM, IgM, and immune-related genes transcriptions. In summary, it could be suggested that EGCG supplementation enhanced the nonspecific immune response of the Chinese rice field eel. Based on the broken-line regression analysis of IgM, the optimal dietary EGCG supplementation for M. albus was estimated to be 109.81 mg/kg.
INEH-VNS Algorithm Solved Automatic Production System Scheduling Problem under Just-in-Time Environment
Authors: Qingxiang Li , Xiaofei Zhao , Yude He , Shaojun Yin
Published: November 2023

Automatic production system scheduling problem under a just-in-time environment is researched in this paper. The automatic production system is composed of many tanks and one robotic, the tank of the researched problem is responsible for processing the job, and the robotic moves the job from one tank to the other tank. The difference between the researched problem and the classic shop scheduling problem is that the former must consider job scheduling and the robotic move sequence, but the latter considers only job scheduling. For optimizing simultaneously job scheduling and robotic move sequence in the proposed problem and minimizing total earliness/tardiness, an improved NEH (Nawaz-Enscore-Ham) and variable search (INEH-VNS) algorithm are developed. In the proposed method, firstly, to obtain initial solution, an improved NEH is shown. Secondly, for computing value of the objective function, the double procedure method is constructed. Thirdly, according to the properties of the proposed problem, three neighborhood structures, adjacent exchange, random insertion, and job exchange, are investigated. To test the performance of the INEH-VNS, 100 instances are randomly generated. When the run time is the same, compared with CPLEX 12.5, the INEH-VNS algorithm can find high-quality approximate optimal solution, a special big scale. Compared with the G-VNS algorithm, the average improvement rate of the approximate optimal solution is 45.9%, and the average stability rate of the INEH-VNS algorithm enhances 75.04%. That is to say, the INEH-VNS algorithm is outstanding and more effective.
Changes in Positive and Negative Affect during Acute Psychiatric Treatment in People with Social Anxiety Disorder
Authors: Bowers Emily M. , Peckham Andrew D. , Goodman Fallon R. , Hom Melanie A. , Beckham Erin , Björgvinsson Thröstur , Beard Courtney
Published: November 2023

People with social anxiety disorder (SAD) experience less positive affect (PA) and more negative affect (NA) than the general population, a pattern more similar to depression than other anxiety disorders. There is a dearth of research assessing whether PA is targeted effectively during treatment, even though this is an important emotional aspect for quality of life. The primary aim of this study was to examine daily changes in self-report PA and NA among a sample of partial hospital program (PHP) patients with SAD. A secondary aim was to examine baseline depression severity as a moderator of daily PA and NA change. Patients were adults (

N
=
241

) diagnosed with SAD seeking treatment at a typically 1–2-week transdiagnostic behavioral health PHP from September 2017 to September 2019. Patients completed (1) the International Positive and Negative Affect Schedule-Short Form (IPANAS-SF) each treatment day to assess affect and (2) the Patient Health Questionnaire-9 Item Version (PHQ-9) at baseline to assess depressive symptoms. Data from the first nine days of treatment were included in analyses: two-level multilevel model (MLM) analyses were used to address study aim 1, and baseline depression severity was added as a moderator to address study aim 2. Patients reported significant decreases in NA but no significant changes in PA over the course of PHP treatment. Additionally, there was no significant evidence of depression moderating NA change; however, depression did moderate PA change. These findings suggest that patients with SAD report significant decreases in NA but no change in PA over transdiagnostic group treatment, with increases in PA being stronger among patients with more severe depressive symptoms. PA captures an important emotional experience for living a fulfilling life, yet CBT-based treatments may not be effectively improving these areas. Future studies targeting PA in SAD treatment can inform whether doing so ultimately improves treatment outcomes for SAD.
Alström’s Syndrome, Leber’s Hereditary Optic Neuropathy, or Retinitis Pigmentosa? A Case of Misdiagnosis
Authors: Alexopoulos Palaiologos , Symeonidis Chrysanthos , Rotsos Tryfon
Published: November 2023

A case of a patient with the Alström syndrome (AS) that was misdiagnosed as Leber’s hereditary optic neuropathy or retinitis pigmentosa for 13 years is presented. AS is a rare genetic disorder caused by mutations in the ALMS1 gene. AS may lead to abnormal ciliary formation and function. AS affects metabolism, and symptomatology includes type 2 diabetes mellitus (T2DM), obesity, hypogonadism and gynecomastia in males, progressive bilateral sensorineural hearing loss, cardiomyopathy, nonalcoholic fatty liver disease (NAFLD), cirrhosis, and chronic progressive kidney disease. The onset of the above symptoms may vary significantly. The ophthalmic manifestation is early onset cone-rod dystrophy that starts as progressive vision loss, photophobia, and nystagmus in the first months of life. An accurate diagnosis may enable specialists to facilitate a significantly positive effect in the everyday life of a patient. Genetic counseling may also be recommended for these patients. Diagnosis was confirmed by DNA testing, thus highlighting its necessity in everyday practice.
Supplementary Table 2 from Multifactorial Remodeling of the Cancer Immunopeptidome by IFNγ
Authors: Newey Alice , Yu Lu , Barber Louise J. , Choudhary Jyoti S. , Bassani-Sternberg Michal , Gerlinger Marco
Published: November 2023

Supplementary Table 2. Unique peptide count for untreated-exclusive peptides (UEPs) and IFNg-exclusive peptides(IEPs) from our 3 CRC PDOs, separated by NetMHCpan4.1b-attributed HLA.
Association of Cardiovascular Health with Cognitive Function in US Older Adults: A Population-Based Cross-Sectional Study
Authors: Shen Ruihuan , Guo Xuantong , Zou Tong , Ma Lihong
Published: November 2023

Introduction: Promoting cardiovascular health (CVH) by Life’s Simple 7 is associated with better cognitive function. In 2022, the American Heart Association (AHA) prompted Life’s Essential 8 (LE8) to strengthen CVH assessment. This study investigated the association between the new CVH metrics assessed by LE8 and cognitive function, thus providing evidence for implementing LE8 in the primordial prevention of cognitive impairment. Methods: 2,050 participants aged 60 and older from National Health and Nutrition Examination Survey 2011–2014 were included. Cognitive function was measured by the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD), the Animal Fluency Test (AFT), and the Digit Symbol Substitution Test (DSST). The overall and domain-specific cognitive function z-score was created. CVH score was calculated following AHA’s advisory. The multivariable linear regression model estimated the associations. Results: The CVH score assessed by LE8 was independently, positively, and linearly associated with the overall cognitive function. A per-10 point increase in CVH was associated with higher overall cognitive z-scores (β, 0.06; 95% confidence interval [CI], 0.03, 0.09), and participants with moderate (β, −0.14; 95% CI, −0.22, −0.05) and low CVH (β, −0.27; 95% CI, −0.37, −0.16) had lower overall cognitive z-scores compared to participants with high CVH. Similar patterns of associations were observed between CVH of AFT and DSST. Components of CVH were further associated with different domain-specific cognitive functions. Conclusion: Maintaining an ideal CVH improves cognitive function in older adults. Ideal adherence to individual components of LE8 was associated with improved overall and domain-specific cognitive functions. Therefore, promoting CVH according to LE8 might benefit cognitive function in the elderly.
Future Perspective: The Role of Artificial Intelligence in Predicting Investor Behavior: Opportunities and Challenges
Authors: Kaluge David
Published: November 2023

This document delves into the future prospects of Artificial Intelligence (AI) in predicting investor behavior, providing insights into both the potential advantages and the hurdles in its application. It highlights the development of AI in financial contexts, focusing on machine learning algorithms used for predicting investor behavior. Furthermore, it explores opportunities, including the transformative impact of AI on investor behavior prediction. The document also uncovers challenges, such as economic uncertainty, abrupt market changes, and emerging data-related issues when implementing AI. Additionally, it discusses AI's social and ethical implications, particularly concerning data bias. It examines how AI can reshape decision-making in the capital market by synergizing with Big Data and complete information. In summary, this document offers a comprehensive view of AI's role in predicting investor behavior, touching on various aspects, from potential benefits to challenge.
The Integration of Artificial Intelligence (AI) in Assisting with the Mitigation Process for Environmental Issues
Authors: Shofwan Shofwan
Published: November 2023

Climate change has significant implications for human existence, particularly economic activity. Community economic activity positively impacts welfare; nonetheless, it concurrently engenders a deterioration in environmental quality. Numerous mitigating endeavors have been undertaken to reduce the magnitude of this impact, among which artificial intelligence (AI) has been employed for this purpose. There are several domains in which artificial intelligence can play a part in overcoming environmental difficulties, including the design of buildings that are more energy efficient, the monitoring of deforestation, and the optimization of the use of renewable energy. Significant issues of social and environmental concern include the lessening of pollution in the environment, the preservation of natural resources, and the recycling of used materials. Both reducing one's impact on the environment and minimizing that impact continue to be appealing as pollution control methods. These processes are interactive, dynamic, and uncertain, making managing and controlling difficult. The following is a list of some of the ways that artificial intelligence technology can be used to help alleviate environmental problems. The way of AI for doing that is for example reducing technology industry emissions, real time data collection and analysis, measuring carbon footprints, wildlife conservation, monitoring environmental indicators, and improving energy efficiency.
“Un bodrio monumental, sin precedentes”: la génesis de Humedad relativa ambiente: 95% en la correspondencia de Manuel Puig
Authors: Villagarcía Martin
Published: November 2023

Tras la muerte de Manuel Puig el 22 de julio de 1990, uno de los primeros textos inéditos en ser difundidos fue Humedad relativa ambiente: 95%, un proyecto de novela en el que presuntamente habría estado trabajando hasta su último aliento. No obstante, la lectura de su correspondencia alojada en el Archivo Puig rápidamente reveló algo distinto. El presente artículo se propone rastrear el proceso creativo de Humedad relativa ambiente: 95% a la luz de las cartas que Manuel Puig envió a su familia como testimonio de su primera etapa de elaboración, como así también su temprana difusión entre amigos y colegas. La lectura del epistolario no solo es un aporte fundamental para el estudio de la creación de este proyecto de novela, sino también para problematizar su primer abandono. Ni concluido ni abandonado, este proyecto de novela acompañó a Puig durante toda su trayectoria literaria y funcionó como laboratorio de experimentación para muchos de los temas y procedimientos que desarrolló en sus textos publicados, al mismo tiempo que permaneció como una fuente inagotable de recursos disponibles para su uso.
Música & missivas: uma conversa com João Guilherme Ripper sobre “Domitila” e “Cartas Portuguesas”, suas óperas epistolares
Authors: Pereira Patrícia Regina Cavaleiro
Published: November 2023

Entrevista com o compositor e regente João Guilherme Ripper sobre suas óperas epistolares, "Domitila" e "Cartas Portuguesas".
Victoria Ocampo, una “empedernida escribidora de cartas”
Authors: Barral Manuela
Published: November 2023

En 1971, Victoria Ocampo se define a sí misma como “una empedernida escribidora de cartas” y afirma: “Mis Testimonios son cartas disfrazadas, tal vez”. A partir de esta autofiguración, se trabajará el específico uso autoral que Ocampo le daba a su correspondencia como espacio híbrido, entre lo privado y lo público, para habilitar su escritura autobiográfica en un campo intelectual patriarcal. En 1931, en el número uno de Sur, incorporaba una carta personal que le había enviado a Waldo Frank para explicar el proyecto de la revista; en 1935, iniciaba el primer tomo de sus Testimonios recreando su intercambio epistolar con Virginia Woolf; luego, en su Autobiografía, de publicación póstuma, también incluye fragmentos de cartas de distintos remitentes y algunas enviadas a Delfina Bunge, Pierre Drieu La Rochelle y el Conde de Keyserling. Por último, al final de su vida, decide que sus más de 4000 cartas sean conservadas en la Universidad de Harvard. Se desarrollará la hipótesis de que para Victoria Ocampo sus cartas formaban parte de su obra literaria.
Trânsitos e margens nas cartas a Murilo Miranda
Authors: Silva Mônica Gomes da
Published: November 2023

Na correspondência do jornalista Murilo Miranda, editor da Revista Acadêmica, é possível conhecer aspectos do trabalho de escritores que se propuseram a criar e difundir a moderna literatura brasileira, exercendo, também, as funções de crítica literária, editoração e tradução, entre as décadas de 1930 e 1940. Nas cartas a Murilo, registram-se os trânsitos culturais de Luís Martins, Lídia Besouchet e Newton Freitas. A partir de margens, físicas ou figurativas, esses autores evidenciam as disputas simbólicas do cenário literário daquele momento e que, depois, repontaram na consolidação de um repertório crítico sobre o Modernismo. Assim, o artigo propõe a leitura e análise dessas cartas, com destaque para as questões concernentes à inserção e à circulação das obras dos escritores selecionados. Para a fundamentação teórica, recorrem-se aos estudos de Antonio Candido (2011), Lívia Rangel (2016), Luiz Lafetá (2000) e Sérgio Miceli (1979). Destaca-se, por fim, a importância da Revista Acadêmica como espaço de uma crítica estética (LAFETÁ, 2000) e de projeção da literatura modernista, cuja dinâmica se revela nas cartas a Murilo Miranda.
How to be Critical of Security Today? Life in Motion, Untimeliness and the Critique of End-Thinking
Authors: Huysmans Jef
Published: November 2023

This article starts from the observation of intense political mobilisations of existential endings. One of the defining challenges for critical engagements with such mobilisations remains how to take war, environmental degradation and pandemics seriously without making existential end-times the conditions that define the present. The article proposes to move beyond critical knowledge that makes security contingent and engage with the conception of life inscribed in the mobilisations of existential endings. It puts forward a concept of life that emphasises continuous movement rather than defining it from the perspective of its inevitable end in death. This point of view challenges traditional existential notions of life and death, highlighting instead the dynamic and transformative nature of life itself.
Comparative genotypic characterization related to antibiotic resistance phenotypes of clinical carbapenem-resistant Acinetobacter baumannii MTC1106 (ST2) and MTC0619 (ST25)
Authors: Wiradiputra Made Rai Dwitya , Thirapanmethee Krit , Khuntayaporn Piyatip , Wanapaisan Pagakrong , Chomnawang Mullika Traidej
Published: November 2023

Background

The prevalence of Acinetobacter baumannii in nosocomial infections and its remarkable ability to develop antimicrobial resistance have been a critical issue in hospital settings. Here, we examined the genomic features related to resistance phenotype displayed by carbapenem-resistant A. baumannii (CRAB) MTC1106 (ST2) and MTC0619 (ST25).

Results

Resistome analysis of both strains revealed that MTC1106 possessed higher numbers of antimicrobial resistance genes compared to MTC0619. Some of those genetic determinants were present in accordance with the susceptibility profile of the isolates. The predicted ISAba1 region upstream of blaOXA-23 gene was related to carbapenem resistance since this IS element was well-characterized to mediate overexpression of carbapenemase genes and eventually provided capability to confer resistance. Unlike MTC0619 strain, which only carried class B and D β-lactamase genes, MTC1106 strain also possessed blaTEM-1D, a class A β-lactamase. Regarding to aminoglycosides resistance, MTC0619 contained 5 related genes in which all of them belonged to three groups of aminoglycosides modifying enzyme (AME), namely, N-acetyltransferase (AAC), O-nucleotidyltransferase (ANT), and O-phosphotransferase (APH). On the other hand, MTC1106 lacked only the AAC of which found in MTC0619, yet it also carried an armA gene encoding for 16S rRNA methyltransferase. Two macrolides resistance genes, mph(E) and msr(E), were identified next to the armA gene of MTC1106 isolate in which they encoded for macrolide 2’-phosphotransferase and ABC-type efflux pump, respectively. Besides acquired resistance genes, some chromosomal genes and SNPs associated with resistance to fluoroquinolones (i.e. gyrA and parC) and colistin (i.e. pmrCAB, eptA, and emrAB) were observed. However, gene expression analysis suggested that the genetic determinants significantly contributing to low-level colistin resistance remained unclear. In addition, similar number of efflux pumps genes were identified in both lineages with only the absence of adeC, a part of adeABC RND-type multidrug efflux pump in MTC0619 strain.

Conclusions

We found that MTC1106 strain harbored more antimicrobial resistance genes and showed higher resistance to antibiotics than MTC0619 strain. Regarding genomic characterization, this study was likely the first genome comparative analysis of CARB that specifically included isolates belonging to ST2 and ST25 which were widely spread in Thailand. Taken altogether, this study suggests the importance to monitor the resistance status of circulating A. baumannii clones and identify genes that may contribute to shifting the resistance trend among isolates.