bluuebunny/crossref_metadata_2025 huggingface dataset:
Circular Economy, Solid Waste Recovery, and Growth: An Empirical Analysis for Sustainable Development in the 100th Anniversary of the Republic
Authors: MİÇOOĞULLARI Seyit Ali , MOALLA Maya
Published: October 2023

This article aims to examine the relationship between solid waste recycling and economic growth within the framework of the circular economy perspective in Turkiye. As Turkiye approaches its 100th anniversary of the Republic, achieving a sustainable and inclusive economic growth goal is of paramount importance. Solid waste recycling is now recognized as a process that not only reduces waste but also contributes positively to both economic growth and environmental preservation. In this context, the study utilizes quarterly data from 1994Q1 to 2020Q4 to comprehensively analyze the impact of solid waste recycling on the Turkish economy. The analyses were conducted using the Bootstrap Autoregressive Distributed Lag (BARDL) methodology. The results confirm that solid waste recycling has a positive influence on economic growth in both the short and long terms. This underscores the essential role of solid waste recycling as a fundamental component of the circular economy, emphasizing its potential to contribute to Turkiye's sustainable growth goals. Additionally, the study offers policy recommendations based on these findings. These recommendations include accelerating the transition to a circular economy, investing in technological innovations and infrastructure enhancements, organizing awareness and education programs, fostering collaboration between the public and private sectors, adopting innovative financing approaches, and establishing comprehensive legal regulations. In conclusion, the findings and recommendations of this study can contribute to Turkiye's achievement of sustainable economic growth and development goals, particularly as it approaches the 100th anniversary of the Republic. Prioritizing solid waste recycling as part of the circular economy vision can help create a better living environment and a sustainable future for the upcoming generations.
Ortak Kimlik Hafızasının Oluşturulma Sürecinde Cumhuriyet Bayramı Kutlamaları: Gümüşhane Örneği (1933-1940)
Authors: UÇAR Uğur
Published: October 2023

Millî Mücadele’nin başarılı bir şekilde sonuçlanmasının ardından Türk Devleti’nin siyasi rejiminin adı 29 Ekim 1923 tarihinde konulmuştur. Cumhuriyet, sadece bir devlet şeklini değil aynı zamanda Anadolu İhtilali ile ilk yapraklarını açan Türk tarihinin temelini oluşturmaktadır. Cumhuriyet, Türk milletinin hem siyasi rejimi hem de yaşama iradesidir. Bu durumun en önemli göstergesi ise Cumhuriyet’in ilanının bayram olarak kutlanmasıdır. Cumhuriyet’in ilanı kutlama törenleri hem yurtiçinde hem de yurtdışı temsilciliklerinde büyük bir coşku içerisinde gerçekleşmiştir. Gümüşhane’de de Cumhuriyet Bayramı kutlamaları halk tarafından bayram havasında kutlanmıştır. Cumhuriyet kutlamaları, genel merkez tarafından belirlenen program dâhilinde gerçekleşmiş ve bu törenler inkılâpların yerleşmesi hususunda çok önemli görevleri yerine getirmiştir. Bu kutlamalar ile Cumhuriyet’in önemi her kesimden halka anlatılarak halkın yeni siyasi rejim hakkında bilgi sahibi olması sağlanmıştır. Böylece bayram kutlamaları, halkın kaynaşması ve millî değerleri yakından tanıyarak benimsemesi için en iyi araç görevini üstlenmiştir. Gümüşhane’de Cumhuriyet Bayramı kutlamaları toplumsal birlikteliği sağlayarak ortak bir kimlik hafızası oluşturmuştur. Bahse konu olan kutlamalar sayesinde siyasi rejime karşı halkın duyguları güçlendirilmiştir. Bu çalışmada 1933-1940 yılları arasında Gümüşhane’de gerçekleştirilen Cumhuriyet Bayramı Kutlamaları ele alınmaktadır. Çalışmanın hazırlanmasında belirlenen tarihler arasında Gümüşhane’de yayınlanan yerel gazeteden, Devlet Arşivleri Başkanlığı Cumhuriyet Arşivi’nden, süreli yayınlardan, telif ve tetkik eserlerden yararlanılmıştır.
Chocó: aventura gastronómica y joya turística del Pacífico colombiano
Authors: Gómez Rodríguez Lida Mariam , Nariño Bernal Viviana
Published: October 2023

Este documento presenta la caracterización de ingredientes, tradiciones y técnicas culinarias propias de Nuquí (municipio), El Valle, Arusí, Panguí y Coquí (corregimientos) del departamento del Chocó (Colombia) que limita con el Océano Pacífico. Región privilegiada ya que cuenta con selva, ríos, manglares y mar, ecosistemas que proveen a sus habitantes diversidad de ingredientes convirtiendo a esta zona apartada en un destino gastronómico y de ecoturismo no solo por sus bellos paisajes sino además por la práctica de avistamiento de ballenas en los meses de julio a octubre. El estudio es de enfoque cualitativo con alcance descriptivo, diseño no experimental, muestreo no probabilístico.  Se realizaron entrevistas a cocineras de tradición, en las que se caracterizaron 9 hierbas de azotea, 15 frutas, 4 variedades de plátanos, 8 pescados – mariscos y 4 productos de origen vegetal empleados como contenedores, envoltorios de alimentos y especias.
Bioethical issues related to the principle of utility in the residential consumption of drinking water in Colombia
Authors: Rodríguez Zambrano Hernando , Díaz Rodríguez Carlos
Published: October 2023

This research seeks to investigate bioethical issues related to the principle of utility in the residential consumption of drinking water in Colombia. The analysis is carried out using the hermeneutic analysis method. The research highlights the influence of the tariff policies implemented between 1994 and 2021, which have depended on the management of the Government, the efficiency of water supply companies, and the freedom of decision-making. The results show, among others, that: the tariff policy has rationalized basic water consumption in vulnerable populations, but with a clear regressive trend; the principle of utility prioritizes financial sufficiency over considerations of efficiency and equity; the cost-benefit analysis adds a moral dimension to the principle of utility, being a basic instrument for increases in water coverage; the high IANC non-billed water index shows the economic inefficiency of the tariff policy, overshadowing the ethical and bioethical considerations evidenced. Bioethics of protection is recommended as an addendum to the Tariff Policy, aimed at universalizing water service for the benefit of the most vulnerable population.
Um enfoque de gênero sobre o programa de pós-doutorado no exterior da CAPES
Authors: Lima Luciana Gasparotto Alves de , Teixeira Maria do Rocio Fontoura
Published: October 2023

No Brasil, onde ocorre paridade de gêneros na população geral, houve nos últimos anos uma predominância de mulheres enquanto tituladas da graduação, bem como crescimento da presença feminina no campo científico. Porém, sucessivamente, ocorre diminuição percentual da representatividade feminina ao se avançar academicamente, passando por mestrado, doutorado e finalmente pelo pós-doutorado. O estudo tem como objetivo analisar a distribuição de gêneros no Programa de Pós-Doutorado no Exterior (PPDE) da CAPES nas etapas de inscrição, concessão e implementação, verificando se há menor procura pelas bolsas do programa por parte das mulheres ou se há menor seleção, mesmo havendo demanda. Caracteriza-se como análise exploratória quantitativa dos dados de inscrição, concessão e implementação de bolsas do PPDE tendo como foco a distribuição entre gêneros, contemplando o período de 2003 a 2018. Entre os principais resultados, destaca-se a menor candidatura às bolsas por parte das mulheres, além de seleção ainda menor proporcionalmente em relação aos homens.
A Review on the Recent Progress of Layered Double Hydroxides
(LDHs)-based Catalysts for Heterocyclic Synthesis
Authors: Farouki Khadija El , Kacem Marieme , Dib Mustapha , Ouchetto Hajiba , Hafid Abderrafia , Khouili Mostafa
Published: October 2023

Over the past decade, heterocyclic compounds and their derivatives have emerged as
promising substances with potential pharmacological applications due to their interesting biological
properties. The significance of heterocyclic compounds in drug discovery and development is evident from the fact that a majority of drugs in the pharmaceutical market incorporate heterocyclic
compounds as active substances or ingredients. Various synthetic methods and advancements have
been devised to prepare these heterocyclic compounds using diverse catalysts under mild conditions. Layered double hydroxides (LDHs)-based materials have gained considerable attention
across different fields, and their usability can be significantly enhanced via the selection of metal
cations, their molar ratios, surface complexation, and intercalation modifications. The synthesis and
application of LDH-based materials as catalysts have garnered increasing interest due to their exceptional properties. Moreover, LDH-based materials have found extensive use as heterogeneous
catalysts in the synthesis of numerous heterocyclic compounds. This review presents the latest developments in the catalytic application of LDH-based materials as solid heterogeneous catalysts in
the synthesis of heterocyclic compounds, covering literature published from 2018 to 2023.
Effects of Probiotics and Magnesium Co-supplementation on Stress Levels and Quality of Life in Obese Patients with Depressed Mood: A Randomized, Double-blinded Placebo-controlled Clinical Trial
Authors: Ghasvarian Marzieh , Mahboobi Sepideh , Sadeghi Reza , Ghaem Haleh , Hedayati Arvin , Alipour Shohre , Valisoltani Neda , Harsini Asma Rajabi , Eftekhari Mohammad Hassan
Published: October 2023

Background and Objectives:

Obesity is strongly associated with mood disorders. There is evidence that obesity and mood disorders may be related pathologically. Depression and manic episodes are more common among overweight or obese individuals. Human subjects have reported the restorative effects of probiotic supplementation on neuroendocrine functions. Gut microbiota, neuroendocrine status, and obesity are related. Magnesium enriches the gut microbiota. Based on the association between gut microbiota, magnesium levels, obesity, and neuropsychiatric disorders, we examined the possibility of co-supplementation of probiotics and magnesium in humans.

Methods:

For 74 individuals, demographic data, quality of life scores (SF -12), depression, anxiety, and stress scores (DASS-21) were collected, along with body mass index (BMI), waist circumfer-ence, and serum cortisol levels. An SPSS analysis was performed.

Results:

Both the intervention and control groups experienced significant reductions in depression, anxiety, and stress. A significant improvement in mental health, role-emotional function, and vital-ity was observed in the probiotic and magnesium supplement group.

Conclusion:

Magnesium supplements and probiotics increased vitality (VT) and mental health (MH) and reduced functional impairment from emotional stress (RE). They experienced fewer functional limitations because of physical conditions.
Weaning Failure in Mechanical Ventilation
Authors: Perdana Sakti Pradhika , Anjarwani Setyasih , Prasetya Indra , Astiawati Tri
Published: October 2023

Mechanical ventilation is a method of ventilation support through positive pressure breath application. It is used in cases of ventilation and/ or oxygenation failure. Due to its related complications mechanical ventilation should be withdrawn from the patient as soon as possible, called a weaning process. The result of the weaning of mechanical ventilation determines the patient’s prognosis. Patient will go through several assessments before a weaning decision is made. Subsequently, patient will be placed on an unconstrained breathing test (SBT) to check whether the patient's respiratory muscle is equipped for accepting its work of relaxing. Weaning disappointment is characterized as disappointment on SBT or reintubation at 48 hours following extubation. Several factors related to weaning failure are increasing airflow resistance, decreasing compliance, respiratory muscle fatigue, and the patient’s underlying conditions. Techniques to conquer these variables are expected to lessen the pace of disappointment of the weaning system. Keyword: Mechanical Ventilation, Respiratory Failure, Weaning Failure.
The Association between CHA2DS2-VASC Score with Increased Serum Creatinine Level in ACS Patients Undergoing PCI at RSUD Dr. Saiful Anwar Malang
Authors: Fathoni Emil , Widito Sasmojo , Anjarwani Setyasih , Satrijo Budi , Yogibuana Swastika Putri Valerinna
Published: October 2023

Background: The current literature on the relationship between the congestive heart failure, hypertension, age, diabetes mellitus, prior stroke or TIA or thromboembolism, vascular disease, age, sex category (CHA2DS2-VASc) score and increased Serum Creatinine (SCr) among Acute coronary syndrome (ACS) patients is noticeably limited in scope. Objective: Therefore, the primary objective of this study was to assess the correlation between CHA2DS2-VASc score with increased of Serum Creatinine in patients with ACS undergoing Percutaneous coronary intervention (PCI) procedures. Material and Methods: In this study, a total of 527 participants were recruited, comprising two groups: Increased SCr level (n=159) and normal SCr level (n=368). Data pertaining to clinical information and demographic characteristics, such as gender, age, diabetes mellitus (DM), hypertension (HT), congestive heart failure (CHF), history of stroke or transient ischemic attack (TIA), and vascular disease, were gathered from various sources, including registry data and medical records, diagnostic physical examination, electrocardiography and laboratory records. Logistic regression analysis was employed to assess the association between the CHA2DS2-VASc score and the incidence of increased SCr level. Result: In our study, we observed that the CHA2DS2-VASc scores were significantly higher in the group of patients who increase SCr level compared to those who did not increase SCr level. Furthermore, our Receiver Operating Characteristic (ROC) analysis revealed that a CHA2DS2-VASc score cutoff of was determined to be the optimal threshold for estimating the increased SCr level (AUC= 0.805, 95% CI 0.762-0.848; p<0.01). Conclusion: The CHA2DS2-VASc score serves as a valuable tool for estimating the likelihood of SCr in patients undergoing PCI, offering a foundational assessment. Additionally, in PCI patients, an increase in the CHA2DS2-VASc score exceeding 3 is indicative of a heightened incidence of increased SCr level. Keyword: Acute Coronary Syndrome, CHA2DS2-VASc score, Percutaneous Coronary Intervention, Serum Creatinine Level.
Removal of two Textile Dyes using Aspergillus niger
Authors: Almamoori Anas M. , Kadhum Hadeel A. , Ibrahim Israa H.
Published: October 2023

The current study included studying the possibility of fungi in removing two
types of dyes used in textile factories (red and yellow). Three concentrations of
dyes (500, 100 and 300) ppm were treated with fungi and measured. Removal efficiency was measured after 72 hours, and the fungus was more efficient in removing the red dye. The removal efficiency was (99.77, 96.02 and 92.19) % for
the red dye and (94.11, 93.65, and 88.9) % for the yellow dye. Results indicated
that the degradation rate of the low concentrations was higher than that of high
concentrations of both dyes. The results recorded decreased pH values for both
dyes and all concentrations. It decreased from (7.33, 7.27 and 7.27) to (4.83, 4.83
and 4.87) after 72 hours of red dye treatment and from (7.23, 7.23 and 7.27) to
(4.83, 4.83 and 4.8) for the yellow dye. The electrical conductivity also decreased
for dyes and all concentrations, from (1509, 1466 and 1501.33) microsiemens/cm
to (968, 975 and 972.33) microsiemens/cm for the red dye. At the same time, it
decreased from (1472.67, 1481 and 1487) microsiemens/cm to (988.33, 997 and
999.33) Microsiemens/cm for yellow dye. Total dissolved solids values also decreased for both dyes, and all concentrations decreased from (1011, 982 and
1005)mg/l to ( 648, 653 and 651) mg/l from the red dye. At the same time, the
yellow dye decreased from (986, 992 and 996) mg/l to (662, 667 and 669) mg/l.
Keywords: Textile Dyes, Aspergillus niger, pollution
The effect of agricultural exploitation and physiographic location on the soil
particle size distribution for soils in Diyala Governorate
Authors: Radhi Jubier Amal , Thabit Ail Mustafa
Published: October 2023

The study area was chosen to include three physiographic sites on the Diyala
River, as it is located in the village of Umm Al-Azam between longitudes
33.71785 east and latitudes 44.6185 north. There are four pedons in each A
physiographic unit, two of which are in cultivated sites and the other two are in
unexploited agricultural sites, so the total of the studied pedons is twelve. The
results of laboratory analyses showed that the sand content in the physiographic
units of the cultivated soils ranged between 151.19 - 583.20 g kg-1
, as it was noted
that the highest content was in the soils of river basins, while in the physiographic
units of the abandoned soils, the sand content ranged between 146.62 - 600.50 g kg
-1
, as its highest content was in soils River basins as well. As for the silt particle, the
results showed that its content in the physiographic units of the cultivated soil
ranged between 170.00 - 543.11 g kg-1
, as it was noted that its highest content was
in the soils of the depression unit, while in the physiographic units of the abandoned soils, the content of the silt ranged between 54.42 - 553.01 g kg-1
, as the
highest content was in pedons soils the river. As for the particle clay, its content in
the cultivated physiographic units ranged between 52.10 - 375.67 g kg-1
, as the
highest content was in the soils of river levee, while in the soils of the abandoned
physiographic units, it ranged between 54.42 - 335.57 g kg-1
, which was the
highest value for it. When soils levee of rivers .
Keywords: particle, distribution, physiographic location, agricultural exploitation
Cytotoxic effects of L.asparginase Purified from Lactobacillus reuteri on breast cancer cell lines
Authors: Hussein Hassan Zaman , Ghadban Auda Ibtesam , Hamied Mahdi Likaa
Published: October 2023

L-asparagine is an enzyme widely identified as one of the most potential anticancerous drugs. This enzyme is poorly bioavailable, so its pharmaceutical uses are limited as an anticancer. L-asparaginase is an important chemotherapeutic drug used to treat a variety of malignant tumors. Lactic acid bacteria may exhibit high L-asparaginase productivity, efficiency, and anticancer activity against breast cancer cell lines. The L-asparaginase was extracted and purified in multiple processes, including precipitation with (NH4)2SO4 (70%), DEAE-cellulose ion exchanger chromatography, and Sephadex G 150 filtration. The specific activity was 40 U/mg, and the purification fold was 25.6, yielding 51%. The cytotoxic effect of the enzyme on treated cells was dose-dependent, with an IC50 value of 4.305 IU/ml. Keywords: Cytotoxic effects, L-asparagine, Lactobacillus reuteri, breast cancer cell line
Data Analysis of Physician Competence Research Trend: Social Network Analysis and Topic Modeling Approach (Preprint)
Authors: Yune So Jung , Kim Youngjon , Lee Jea Woog
Published: October 2023

UNSTRUCTURED

Studies on competency in medical education often explore the acquisition, performance, and evaluation of particular skills, knowledge, or behaviors that constitute physician competency. As physician competency reflects social demands according to changes in the medical environment, analyzing the research trends of physician competency by period is necessary to derive major research topics for future studies. Therefore, a more macroscopic method is required to analyze the core competencies of physicians in this era. This study aimed to analyze research trends related to physicians’ competency in reflecting social needs according to changes in the medical environment. We used topic modeling to identify potential research topics by analyzing data from studies related to physician competency published between 2011 and 2020. We preprocessed 1354 articles and extracted 272 keywords. The terms that appeared most frequently in the research related to physician competency since 2010 were knowledge, hospital, family, job, guidelines, management, and communication. The terms that appeared in most studies were education, model, knowledge, and hospital. Topic modeling revealed that the main topics about physician competency included Evidence-based clinical practice, Community-based healthcare, Patient care, Career and self-management, Continuous professional development, and Communication and cooperation. We divided the studies into 4 periods (2011-2013, 2014-2016, 2017-2019, and 2020-2021) and performed a linear regression analysis. The results showed a change in topics by period. The hot topics that have shown increased interest among scholars over time include Community-based healthcare, Career and self-management, and Continuous professional development. On the basis of the analysis of research trends, it is predicted that physician professionalism and community-based medicine will continue to be studied in future studies on physician competency.
Clinical Decision Support System Used in Spinal Disorders: Scoping Review (Preprint)
Authors: Toh Zheng An , Berg Bjørnar , Han Qin Yun Claudia , Hey Hwee Weng Dennis , Pikkarainen Minna , Grotle Margreth , He Hong-Gu
Published: October 2023

BACKGROUND

Spinal disorders are highly prevalent worldwide with high socioeconomic costs. This cost is associated with the demand for treatment and productivity loss, prompting the exploration of technologies to improve patient outcomes. Clinical decision support systems (CDSSs) are computerized systems that are increasingly used to facilitate safe and efficient health care. Their applications range in depth and can be found across health care specialties.

OBJECTIVE

This scoping review aims to explore the use of CDSSs in patients with spinal disorders.

METHODS

We used the Joanna Briggs Institute methodological guidance for this scoping review and reported according to the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews) statement. Databases, including PubMed, Embase, Cochrane, CINAHL, Web of Science, Scopus, ProQuest, and PsycINFO, were searched from inception until October 11, 2022. The included studies examined the use of digitalized CDSSs in patients with spinal disorders.

RESULTS

A total of 4 major CDSS functions were identified from 31 studies: preventing unnecessary imaging (n=8, 26%), aiding diagnosis (n=6, 19%), aiding prognosis (n=11, 35%), and recommending treatment options (n=6, 20%). Most studies used the knowledge-based system. Logistic regression was the most commonly used method, followed by decision tree algorithms. The use of CDSSs to aid in the management of spinal disorders was generally accepted over the threat to physicians’ clinical decision-making autonomy.

CONCLUSIONS

Although the effectiveness was frequently evaluated by examining the agreement between the decisions made by the CDSSs and the health care providers, comparing the CDSS recommendations with actual clinical outcomes would be preferable. In addition, future studies on CDSS development should focus on system integration, considering end user’s needs and preferences, and external validation and impact studies to assess effectiveness and generalizability.

CLINICALTRIAL

OSF Registries osf.io/dyz3f; https://osf.io/dyz3f
Evaluation of an Online-Based Self-Help Program for Patients With Panic Disorder - A Randomized Controlled Trial (Preprint)
Authors: Lalk Christopher , Väth Teresa , Hanraths Sofie , Prüssner Luise , Timm Christina , Hartmann Steffen , Barnow Sven , Rubel Julian
Published: October 2023

BACKGROUND

Panic disorder, with and without agoraphobia, can be a highly debilitating disorder leading to functional impariments, increased risk of developing comorbidities, and a reduced quality of life. Panic disorder comes with a higher economic burden than other anxiety disorder, mainly due to absenteeism.

OBJECTIVE

The present study evaluated the effectiveness of a minimally-guided online self-help intervention for panic disorder with or without agoraphobia. As our primary hypotheses, we expected the intervention to improve both panic symptoms and well-being.

METHODS

German-speaking patients (N=156) between 18 and 65 with internet access and a diagnosis of panic disorder or agoraphobia with panic disorder were recruited for this randomized controlled trial. The intervention group (N=84) received access to a 12-week online self-help program. The waitlist control group (N=72) received care as usual during the study period and was offered the prospect of using the program after 12 weeks.

RESULTS

Changes in PAS revealed a significant effect in favor of the intervention group (t (df=110.1)=-2.22, padj=.027) with a small to moderate effect size (d=-0.37, 95%-CI: -0.70; -0.04). No significant effect was found for the second primary outcome WHO-5 (t (df=149.8)=1.35, padj=.088) or the secondary outcomes functioning, mental health literacy, working ability and healthcare use).

CONCLUSIONS

The presented online intervention can help reduce the core symptomatology of panic disorder with or without agoraphobia. Diminished effects may be due to higher illness burden in the intervention group and possibly the COVID pandemic which caused unique challenges to patients suffering from panic disorder. Regarding well-being and the secondary outcomes, superiority towards the control group was not established. Therefore, further research and intervention adaptations may be warranted to improve these outcomes.

CLINICALTRIAL

https://drks.de/search/en/trial/DRKS00023800
Transforming the future of digital health education: Redesign of a graduate program using competency mapping (Preprint)
Authors: Mun Michelle , Chanchlani Sonia , Lyons Kayley , Gray Kathleen
Published: October 2023

BACKGROUND

Digital transformation has disrupted many industries but is yet to revolutionise healthcare. Educational programs must be aligned to the reality that beyond developing individuals in their own professions, professionals wishing to make an impact in digital health will need a multidisciplinary understanding of how business models, organisational processes, stakeholder relationships, and workforce dynamics across the healthcare ecosystem may be disrupted by digital health technology.

OBJECTIVE

To redesign an existing postgraduate program, ensuring that core digital health content is relevant, pedagogically sound and evidence-based, and that the program provides learning and practical application of concepts of digital transformation of health.

METHODS

Existing subjects were mapped to the American Medical Informatics Association (AMIA) Clinical Informatics Core Competencies, followed by consultation with leadership to further identify gaps or opportunities to revise the course structure. New additions of core and elective subjects were proposed to align with the competencies. Suitable electives were chosen based on stakeholder feedback and a review of subjects in fields relevant to digital transformation of health.

RESULTS

The program was revised with a new title, course overview, course intended learning outcomes, reorganising of core subjects, and approval of new electives, adding to a suite of professional development offerings and forming a structured pathway to further qualification.

CONCLUSIONS

Programs in digital health must move beyond purely informatics-based competencies towards enabling transformational change. Postgraduate program development in this field is possible within a short timeframe with use of established competency frameworks, expert and student consultation.
Teachers’ Classroom Discourse Pattern for Postgraduates Majoring in Foreign Linguistics: A Perspective of Legitimation Code Theory
Authors: Xi Wang , Rong Jiang , Jiashuai Li
Published: October 2023

“Introduction to English Linguistics (IEL)” is a professional knowledge course for postgraduates majoring in Foreign Linguistics. In traditional classrooms, teachers usually use knowledge code in their discourse, emphasizing the inculcation of theoretical knowledge in Foreign Linguistics. However, faced with large numbers of concepts, terminology, and academic opinions, students generate lots of confusion. This study quantitatively analyzes the teaching situation of IEL course under the framework of Legitimation Code Theory, and explores the influence of different teachers’ classroom discourse patterns on students’ learning efficiency. It is found that the use of knower code in teachers’ classroom discourse is an important factor in students’ learning efficiency while not being affirmatively proved to be effective in a pronounced manner, suggesting that a more advanced model of teachers’ classroom discourse pattern combining both knowledge code and knower code for postgraduates majoring in Foreign Linguistics is urgently needed.
POLYMERIC MATERIALS AS PLATFORMS FOR TOPICAL DRUG DELIVERY: A REVIEW
Authors: Teo Siew Yong , Lee Siang Yin , Rathbone Michael J. , Gan Seng Neon
Published: October 2023

With the emergence of novel and more effective drug therapies, increased importance is being placed upon the drug delivery technology. Topical formulations are attractive alternatives to oral formulations and offer several advantages, such as avoiding first-pass hepatic metabolism and gastric degradation. The major obstacle to drug delivery across the skin (transdermal) is the barrier nature of the skin which limits permeation of molecules. A wide range of polymeric materials is currently available for drug delivery to and across the skin. The synthetic polymers such as polyesters, polyamides, polyurethanes, polyanhydrides and poly(ortho-esters) display advantages of reproducibility of synthesis, a range of material properties and biodegradability, whereas agro-polymers like polysaccharides, proteins and lipids have already shown great promise in terms of type of material, range of properties, processing technique and biocompatibility. This review article summarizes features of different polymers and their potential applications in topical drug delivery system.
CINNAMOMUM GENUS: A REVIEW ON ITS BIOLOGICAL ACTIVITIES
Authors: Balijepalli Madhu Katyayani , Buru Ayuba Sunday , Sakirolla Raghavendra , Pichika Mallikarjuna Rao
Published: October 2023

The objective of this review is to systematically appraise the literature available to date on biological activities (in vitro and in vivo) of extracts and constituents from Cinnamomum. An extensive review of the literature available in various recognised databases including PubMed, Google Scholar and Scopus on the biological activities of various species of the Cinnamomum were undertaken. The literature provided information on biological activities of the species of the genus Cinnamomum. Crude extracts and constituents from about 30 species of Cinnamomum displayed significant antibacterial, antifungal, antiseptic, antiviral, anti-inflammatory, antipyretic, antioxidant, chemopreventive, cytotoxic, antidiabetic, hypolipidemic, antispasmodic, antiulcer, antiplatelet, anodyne, choleretic, immunostimulant, anaesthetic and sedative activities. Essential oil, aqueous/alcoholic extracts, cinnamaldehyde and proanthocyanidins were reported to be mainly responsible for biological activities displayed by most of the plants. Plants of Cinnamomum genus possess a wide spread of biological activities validating their use in traditional medicine. However, most of the available references lack information on active constituents, doses, duration of the treatment, storage conditions and positive controls for examining biological activities. The molecular mechanisms involved in eliciting biological activities were not comprehensively elucidated. Investigations to prove the safe use of these plants in traditional medicine are very limited. Thus, more studies on identification of bioactive constituents and their molecular mechanisms are needed. In addition, given that various species of Cinnamomum are being widely used in traditional medicine and culinary purposes, their main therapeutic aspects, toxicity, and adverse effects warrant further investigation in the future.Â
The Protective Effect of Ramelteon and in combination with Dexamethasone on the Lipopolysaccharide-induced Cytokine Storm in mice
Authors: A. Al-dabbagh Marwa , B. Sahib Hayder
Published: October 2023

Cytokine Storm Syndrome (CSs) is a potentially life threatening condition, characterized by robust elevated; of circulating pro- inflammatory cytokines; occurring after a hyperactive immune system. Is a well-known as a worldwide health problem, leading to multi-organ failure and death. Objectives: This study was carried out to investigate the protective role and probability of additive or synergistic anti-inflammatory activity; of ramelteon and in combination with dexamethasone on the lipopolysaccharide (LPS) induced “Cytokine Storm” on mice model and its potential regulatory mechanism(s). Methods:  Sixty Swiss albino male mice of ;( 25 ± 5 grams; 8-12 weeks) had free access to food and water. After 2weeks of adaptation, mice; randomly separated in five groups (n =12): Group I, mice received (0.9% N\S i.p.); Group II, mice received (5mg\kg i.p.) LPS only .Group III, mice received (2.5mg/kg, i.p.) dexamethasone, Group IV, mice received (100mg/kg i.p.)  ramelteon, Group V, mice received half dose of dexamethasone+ ramelteon combination (1.25 mg\kg i.p +50mg\kg i.p). For systematic inflammatory stimulation mimicking “cytokine storm” LPS; E. coli O55:B5 (5mg\kg i.p.) was induced within one hr. After 48h the effects of interventional agents and vehicle or LPS challenge; on lung, heart, liver, kidney histopathological changes, and levels of inflammatory cytokines :( IL-6, IL8 IL-1β, and TNF-α) in the serum were detected. Results: IL-1β, IL-6, IL8 and TNF-α elevated serum levels significantly reduced (p<0.001) in all treatment group. Additionally, they ameliorated the histopathological changes induced by (LPS) and improving macroscopic scores (p<0.001). Conclusion: In conclusion, ramelteon treatment had a diverse protective effects against “Cytokine Storm”  with a mechanism  based on attenuation serum levels of inflammatory cytokines (IL-1β, IL-6, IL-8 and TNF-α)and through reduction of histopathological damage during endotoxemia induced via LPS challenge on male mice model. RAM/DEX combination had superior advantage than an agent use alone probably via synergistic anti-inflammatory activity.
In silico study of new carbonic anhydrase inhibitor derivatives bearing 1, 3, 4-Oxadiazole moiety with promising anti-cancer activity.
Authors: Saad Aljubouri Riyam , H. Naser Noor
Published: October 2023

Objectives: Molecular docking simulations were performed to assess the theoretical binding affinities of six (6) compounds created where they are derivatives having 1,3,4, oxadiazole moiety, and their target was cancer and Human carbonic anhydrase IX (PDB code: 6U4T). Using ChemDraw Ultra 12.0, the molecular structure was meticulously sketched. Molecular Operating environment software was used to verify the developed compounds by looking at their S. score and Rmsd values. Promising activity was seen with these proteins from the theoretically generated compounds, which exhibited strong binding contacts with the receptor active pocket.

 

Methods: Chemically by joining together several oxadiazole derivatives, sulfanilamide analogues (IVa-IVd) may be created in the lab. Molecular docking and ligand/receptor priming by MOE software.

Results: Acetazolamide was selected because it had the same pharmacophore as the sulfanilamide group, and cisplatin was used in clinical trials for cancer therapy. IVc and IVa yielded max score and irrevocable relationship compared with acetazolamide and cisplatin.

Conclusion: The MOE docking results validated the potent anticancer activity, the identified compounds showing good binding affinity with target proteins relative to the reference drugs (Acetazolamide and cisplatin). The most effective anticancer compounds were IVc and IVa, which yielded a maximum score with a Rmsd of less than 2, the MOE docking results were able prove this.

Compounds IVc and IVa exhibited the greatest cytotoxic impact of the synthetic compounds against MCF7, and all four synthesized compounds showed a superior safety profile than the standards in MCF10a.
Cutaneous Angiosarcoma of the Scalp Aggravated after Hair Dyeing Presenting as Bilateral Facial Cellulitis: A Case Report
Authors: Kwak Si Hyun , Lee Da Woon , Kim Jun Hyuk , Choi Hwan Jun
Published: October 2023

Angiosarcoma is a rare and aggressive soft tissue sarcoma. The cutaneous form of angiosarcoma occurs most commonly in the head and neck region, especially the scalp. Because of its aggressiveness and tendency for distant metastasis and local recurrence, early diagnosis of angiosarcoma is critical. We report a case of cutaneous angiosarcoma of the scalp aggravated by hair dyeing. In this case, it presented as bilateral facial cellulitis because of the progression of an infection. The patient was not aware of his malignant lesions on the scalp since they are typically hidden. Meanwhile, infection caused by chemical stimulation from hair dye exacerbated the lesions. However, an early incisional biopsy revealed angiosarcoma with metastasis to the lymph nodes and parotid glands, leading the patient to appropriate chemotherapy. In conclusion, the variable and non-specific findings of cutaneous angiosarcoma can delay the diagnosis; thus, the importance of an excisional or incisional biopsy, which can result in early diagnosis when suspecting malignancy, is highlighted.
A recent tactic for searching CDK-7 kinase inhibitor by NCI database screening
Authors: Rashid Mohammad , Athar Md. Tanwir , Hussain Afzal , Almadani Norah , Hussain Ashfaq
Published: October 2023

The present study was based on an exploration of NCI database for searching specific CDK-7 kinase inhibitor by HTVS, SP, XP, molecular docking, molecular dynamic simulation, and ADMET evaluation. The best CDK-7 kinase inhibitors (NCI613391, NCI169676, NCI281246, NCI339580) were identified via NCI database screening. The stability of binding interaction between receptor protein and protein-ligand complex of potent finding compounds (NCI613391) was further confirmed by dynamics simulations and MM- -GBSA. The RMSD value of receptor and receptor?ligand complexes was analysed, and it revealed the stability of binding interactions and remained stable throughout the simulation. The RMSF values and gyration radius of the unbound receptor and backbone atoms of the complex were found to be equal, which indicates that the drug molecule inside the CDK7 receptor is also stable. The study of MM-GBSA data also revealed stronger binding interactions of ligands to CDK7 receptors. With the exception of NCI169676, all compounds were shown to be substrates for CYP450 2D6, CYP450 3A4, inhibitors of CYP450 2C9, and non-inhibitors of p-glycoprotein. All compounds were qualified and found suitable to be as drug-likeness according to the Lipinski rule, Ghose filter, MDDR like rule and CMC-like rule. The compound (NCI613391) exhibited human intestinal absorption (76.08%), displayed negative AMES and T.E.S.T (US-EPA) toxicity with OSIRIS property and found to be a promising CDK-7 kinase inhibitor and its efficacy may be further explored in clinical trials.
Processing and electrical conductivity property of lithium-doped high-entropy pyrochlore and perovskite ceramics
Authors: Kong Yazhou , Hu Shihang , Cai Chengcheng , Wang Zexiong , Zhang Shuai
Published: October 2023

Lithium-doped Li0.66La1.12(Ti0.2Zr0.2Hf0.2Sn0.2Nb0.2)2O7 (LLTNO),
Li0.66La1.12(Ti0.2Zr0.2Hf0.2Sn0.2Ta0.2)2O7 (LLTTO) high-entropy pyrochlore
and Li0.5Sr0.5(Ti0.2Zr0.2Hf0.2Sn0.2Ta0.2)O3 (LSTTO),
Li0.5Ba0.5(Ti0.2Zr0.2Hf0.2Sn0.2Nb0.2)O3 (LBTNO) high-entropy perovskite
ceramics were synthesized by solid state reaction method and sintered.
Crystal structure, microstructure and electrical properties of these high
entropy ceramics were studied. The LLTNO and LLTTO pellets sintered at 1300
?C present a pyrochlore structure, while LSTTO and LBTNO pellets sintered at
1350 ?C present a perovskite structure. The LBTNO ceramics has a total
conductivity of 1.25 ? 10?7 S?cm?1 at room temperature while the LSTTO
sample exhibits the highest conductivity of 2.11 ? 10?7 S?cm?1 among all
samples. Both LSTTO and LBTNO ceramics present negligible electronic
conductivity. Relative densities of the LLTNO, LLTTO, LSTTO and LBTNO
ceramics were 82, 88, 86 and 87%TD, respectively, which is the reason for
low conductivity of these high entropy ceramics. The activation energies of
the LSTTO and LBTNO samples were 0.39 and 0.38 eV, respectively, which is
close to the traditional Li+-type conducting solid electrolytes.
The Auditor’s Responsibility for Noncompliance with Laws and Regulations: A Case of Unauthorized Account Activity at Wells Fargo
Authors: Keyser John D. , Smith Jason L.
Published: October 2023

In September 2016, the Consumer Financial Protection Bureau (CFPB) announced an enforcement action against Wells Fargo related to improper sales practices. Following investigations revealing widespread abuse by thousands of employees (e.g., opening deposit and credit accounts without customer consent), Wells Fargo paid civil monetary penalties of $185 million and other substantial punitive fees and fines. This case study uses this real-world example to explore the influence of materiality on the scope of an audit, the auditor’s responsibility for detection and communication of noncompliance with laws and regulations (NOCLAR), and the auditor’s consideration of the control environment in the evaluation of internal controls over financial reporting (ICFR). After completing the case, learners are able to discuss relevant professional standards and recognize the impact of materiality considerations on decisions about financial statement misstatements, NOCLAR, and internal control deficiencies.

JEL Classifications: M41; M42.
Covid 19 Pandemisinin Yaşam Tarzındaki Değişim, Çevresel Farkındalık ve Sürdürülebilir Tüketim Üzerine Etkileri
Authors: Gündoğdu Sinem , Sağlam Mehmet
Published: October 2023

Bu çalışmanın amacı, Covid-19 pandemi dönemindeki algılanan kıtlık, duyarlılık, ciddiyet, korku ve kaygı değişkenlerinin yaşam tarzındaki değişim beklentisi, sürdürülebilir tüketim ve çevresel farkındalık üzerindeki etkilerini incelemektir. Ayrıca yaşam tarzındaki değişimin bu ilişkilerde aracı rolü incelenmiştir. Çalışmada kolayda örnekleme ve kartopu örnekleme yöntemi kullanılmıştır. Veriler Google Forms üzerinden online anket aracılığıyla toplanmıştır. Çalışma 292 katılımcı üzerinde gerçekleştirilmiştir. Elde edilen verilerin analizinde SPSS 25 ve AMOS 24 programları kullanılmıştır. Araştırma sonucunda, algılanan kıtlık, ciddiyet ve kaygı yaşam tarzındaki değişim beklentisini etkilerken, yaşam tarzındaki değişim beklentisinin çevresel farkındalık üzerinde ve sürdürülebilir tüketim üzerinde etkili olduğu belirlenmiştir. Algılanan kıtlık, duyarlılık, korku ve kaygı sürdürülebilir tüketim üzerinde etkiliyken, çevresel farkındalık üzerinde kıtlığın ve korkunun etkili olduğu saptanmıştır. Aracı roller incelendiğinde ise yaşam tarzındaki değişim beklentisinin tüm hipotezlerde aracı olduğu sonucuna ulaşılmıştır.
Türkiye’deki Toplum Eczacılarının Yönetim Becerilerinin Değerlendirilmesi
Authors: Coşkun Ronayi , Çalıkuşu Muammer , Özçelikay Gülbin
Published: October 2023

Toplum eczacıları, hastaların ilk temas kurabileceği sağlık uzmanlarıdır. Eczacılardan beklenen mesleki yeterlilikler, reçeteli ilaçların hazırlanması, gözden geçirilmesi ve dağıtılması, araştırma ve eğitim faaliyetlerine katılma becerisi ve ilaçların optimal kullanımının teşvik edilmesi ve buna katkı sağlanmasıdır. Bunların yanı sıra profesyonel ve etik davranış, iş konularını ve kişilerarası ilişkileri yönetme ve eczacılık pratiğinde örgütsel becerileri uygulama ile ilgili üç 'iş' yeterliliği de bulunmaktadır. Liderlik ve yönetim becerileri, hasta ve tüketici memnuniyet sonuçlarını da doğrudan etkilemektedir.
Bu çalışmanın amacı, eczacıların iş becerilerinin belirlenerek; bunların yönetim becerileri çerçevesinde organize edilmesi ve seçilen örneklem dâhilinde toplum eczacılarının yönetsel becerilerine ilişkin bir değerlendirmenin yapılmasıdır.
Bu çalışma betimleyici tip bir araştırmadır. Toplum eczanelerinde yönetim becerileri ile ilgili 5’li likert tipi ifadeler, anket yöntemi ile googleforms aracılığıyla sosyal medyada (facebook, instagram, whatsapp) sadece toplum eczacılarının yer aldığı gruplarda paylaşılarak gönüllü olanların ifadeleri değerlendirmeleri istenmiştir.
Çalışma sonuçlarına göre eczacılar, personeli ile iş birliği içinde olma, onlara adil davranma, empati yapma mesleki etik ve sorumluluk bilinçleri, siparişlerin alınması ve kaydedilmesi hassasiyeti, müşteriye/hastaya karşı güler yüzlü ve anlayışlı olma becerilerinde kendilerini daha yeterli görürlerken; eczacılık hukuku, liderlik ve girişimcilik gibi becerilerde kendilerini daha yetersiz hissettiklerini belirtmiştir.
Brownis Bayam Merah (BROMER) Pencegah Anemia
Authors: Tarisa Yunisyah Hapsari  , Mayra Permata Madani  , Afifah Mutiara Tsany,  , Tsania Khofifah  , Wiwin Atmadinina  , Achyani Fatchan
Published: October 2023

Bayam merah (Amaranthus tricolor) merupakan tanaman pangan bewarna merah yang dapat dikonsumsi daunnya sebagai sayuran. Tanaman ini dapat dibudidayakan di daerah beriklim panas maupun dingin. Bayam merah dikenal sebagai salah satu sumber zat besi yang sangat penting. Dalam bayam merah juga terdapat kandungan protein, lemak, kabohidrat, serat, mineral, vitamin, dan asam oksalat. Bayam merah mempunyai berbagai manfaat untuk kesehatan seperti meningkatkan kadar hemoglobin atau mencegah anemia, menjaga kadar gula darah, meningkatkan daya tahan tubuh, dan sumber protein nabati. Oleh karena itu, kami akan mengolah bayam merah ini menjadi suatu produk yaitu berupa brownies yang digunakan untuk mencegah anemia pada masyarakat. Brownies ini diberi nama “BROMER” (Brownies Bayam Merah).
Kata Kunci : Bayam Merah, Brownis, Anemia
Mengelola Emosi Saat Mendampingi Anak Pembelajaran Jarak Jauh
Authors: Lisnawati Ruhaena  , Permata Ashfi  , Qatrunnada Rizqi Zulfa , Nabilah Dita Silviana  , Aprilia Firdaus  , Farah Aulia Rahmawati  , Ummu Kaltsum
Published: October 2023

Perubahan sistem pendidikan yang awalnya dilakukan secara tatap muka, saat ini harus dilakukan pembelajaran jarak jauh akibat pandemi Covid-19. Pembelajaran jarak jauh mengharuskan orang tua turut serta mengawasi anak selama pembelajaran berlangsung. Pengawasan tersebut kemudian menimbulkan stres dan ketidakmampuan mengelola emosi pada orang tua. Hasil pre-test dan post-test menunjukkan bahwa ... Program pengabdian masyarakat berupa webinar ini dilaksanakan untuk membantu orang tua dan tenaga pendidik mengelola emosi selama pembelajaran jarak jauh. Webinar berisi materi tentang emosi serta bagaimana mengelola emosi tersebut menggunakan berbagai teknik.  Webinar berlangsung dengan lancar dan mampu memberikan insight kepada peserta.
Pelatihan Emotional Spiritual untuk Meningkatkan Kesadaran Diri Remaja di SMP N 2 Karanganyar
Authors: Novita Tri Jayanti  , Woro Ayu Priyanggraeni  , Lisnawati Ruhaena
Published: October 2023

The challenges faced by students today are enormous due to the influence of the environment and the rapid development of technology. Due to technological developments, especially social media and self-control and weak spiritual power, the level of self-awareness of students decreases as seen from the increase in negative behavior of adolescents. In overcoming this, the emotional-spiritual training with the project based learning method is designed to be able to increase students' self-awareness. The research subjects were 32 students of class VIII D at SMP Negeri 2 Karanganyar who were in the age range of 13-14 years. Methods The training is delivered using multimedia, starting with introductory games, lectures, discussions, and reflections through project posters. In the average (mean) pretest results, the results were 54,031 and 57,000 for the posttest average results. The results of data analysis showed a t-value of -5.094 with a significance of 0.000 (p <0.05). So it can be concluded that emotional-spiritual training can increase students' self-awareness.