bluuebunny/crossref_metadata_2025 huggingface dataset:
A Genetic Algorithm Optimization Model for Stability of an Inclined Cutoff with Soil-Embedded Depth
Authors: Al-Suhili Rafea , Karim Rizgar Ahmed
Published: May 2023

A coupled artificial neural network model with a genetic algorithm optimization model is developed for a practical case of a single cutoff. The proposed cutoff is of a soil-embedded vertical part with an inclined extension. The model successfully found the optimum dimensions of the vertical and inclined parts, the optimum angle of inclination, and the optimum length of protection downstream of the cutoff for a factor of safety of 3 against piping. Two thousand one hundred cases are modeled first using Geo-studio software to find the required length of downstream protection against piping for different lengths of the vertical, inclined lengths of the cutoff, its angle of inclination, soil layer depth, and degree of anisotropy. Then the created data set was used to develop an Artificial Neural Network (ANN) model for finding the length of protection required. The ANN model showed high performance with a determination coefficient of (0.922). The genetic algorithm model needs a minimum number of randomly generated populations of 100000 and three crossover iterations to produce a stable optimum solution. Running the model for different practical cases showed that the optimum angle variation was low and fluctuated around 30o. This low angle variation was due to its lower effect on the downstream soil protection length compared to the other decision variables. At the same time, the other dimensions varied with input variables, such as the depth of the soil layer, the seepage driving head, and the degree of isotropy. For a degree of anisotropy (ratio of vertical to horizontal hydraulic gradient) less than 0.5, the results showed no need for protection against piping; hence it is recommended to use minimum dimensions for such a case. The coupled model can easily obtain the optimum dimensions for any given input. Importance analysis showed that the optimum length of the downstream protection was highly affected by the vertical and inclined length of the cutoff, while it was less affected by the angle of inclination. Correlation analysis supported the importance analysis.
TOURISM VILLAGE DEVELOPMENT STRATEGY BY GUNUNGSARI VILLAGE GOVERNMENT SADANANYA DISTRICT CIAMIS DISTRICT
Authors: Abdul Rouf Enjang , Vestikowati Endah , Nursetiawan Irfan
Published: May 2023

This research is motivated by the results of observations which show that the tourism village development strategy by the Gunungsari Village government, Sadananya District, Ciamis Regency is still not optimal. The purpose of this study was to determine the tourism village development strategy by the Gunungsari Village Government, Sadananya District, Ciamis Regency. The method used in this research is descriptive analysis. There are 7 informants. Data collection techniques are library research, field studies (observations and interviews) and documentation. The author uses qualitative data analysis techniques through processing data from interviews and observations to draw conclusions so that they can answer the problems in the study. Based on the results of the study, it is known that: the tourism village development strategy by the village government is not optimal, this is because the village government has not implemented according to the four levels of strategy, this is evidenced by the lack of facilities and infrastructure in tourist villages such as insufficient parking space so that visitors use their shoulders. the road in parking their vehicles in addition to the lack of trash cans so that visitors litter. The promotion system is still lacking in addition to the lack of cooperation with local governments in promoting tourism objects. This is due to the lack of village government in providing guidance and training in the development of tourist villages. Lack of opportunities for local communities to market their work. This is because there is no place to sell the work provided by the village government for the community and there has not been a collection of community works that can be used as souvenirs for visitors who come. Therefore, various efforts have been made, such as maintaining the environment around the tourist village on a regular basis. Adding various facilities and infrastructure that are still lacking and maximizing accessibility and accommodation in tourist villages so that it can make it easier for visitors to come and stay for long at tourist objects and empower local communities by holding business skills training activities so that people can take advantage of existing potential in increasing people's income.
An Antibody Cocktail Combats The Deadly Ebola Virus And Sudan Virus
Authors: Yu Xiaoying , Ollmann Saphire Erica
Published: May 2023

There are several deadly viruses in the ebola virus family, but current antibody treatments are effective against only one. Our work discovered two antibodies from human survivors, and their benefit when combined together in a cocktail, to provide broader protection at a lower dose. We reveal surprising findings of how they act to achieve protection.
Relationship of the severity of talipes equinovarus and age of presentation to time of correction: A focus on Dimeglio scoring
Authors: Ubiomo Erutase Davidson , Lasebikan Omolade Ayoola , Asuquo Joseph , Akpet Obaji Etaba , Asuquo Best Joseph , Aigbomian Ehiosun Jude
Published: May 2023

Objectives:

The Ponseti method is the mainstay of treatment of congenital talipes equinovarus deformity. This study aims to assess the relationship between the severity of the clubfoot deformity and the time it takes to correct the deformity using Dimeglio scoring system (DSS) with Ponseti protocol.

Material and Methods:

A prospective observational study carried out for 15 months at the outpatient department of the National Orthopedic Hospital Enugu. Data collected included age at presentation, sex, laterality, grade of deformity, number of casts, and time to correction before the commencement of bracing. Those selected were clinically assessed using the DSS. Data obtained were analyzed using SPSS version 22.0. The association between time, the number of casts to correction, age of presentation, and severity to the time of correction of deformity was also determined.

Results:

A total of 70 patients (116 feet) were recruited for the study. The mean age at presentation was 21 weeks with a male-to-female ratio of 3:2. The mean DSS at presentation was 10.72. The mean number of casts required to achieve correction was 5, with the last cast left in place for 3 weeks, which gave a mean correction time of 7 weeks. Severe deformity required more cast for correction. There is a weak relationship between age and time to correction.

Conclusion:

Increase in the severity of the clubfeet was associated with longer correction time and a weak correlation with age at presentation. Dimeglio scoring is an effective, grading, and monitoring system.
THE IMPACT OF EMISSIONS FROM AUTONOMOUS HEAT SUPPLY SOURCES ON THE POLLUTION OF THE ATMOSPHERE OF THE CITY OF KRASNOYARSK BY BENZO(A)PYRENE
Authors: Заворуев В.В. , Манкевич И.В. , Заворуева Е.Н.
Published: May 2023

С учетом скорректированных удельных выбросов бенз(а)пирена от автономных источников теплоснабжения произведена оценка их вклада в загрязнение атмосферы г. Красноярска. В расчетах были учтены все источники выбросов бенз(а)пирена, включая Красноярский алюминиевый завод, от которого в атмосферу попадает 0,95 тонн бенз(а)пирена в год. Показано, что вклад автономных источников теплоснабжения в загрязнение атмосферы составляет более 95%, а КрАЗа – около 3%.

The contribution of autonomous sources of heat supply to the air pollution in the city of Krasnoyarsk was assessed, taking into account the specific emissions of benzo(a)pyrene. The calculations took into account all sources of benzo(a)pyrene emissions, including the Krasnoyarsk aluminum plant, from which 0.95 tons of benzo(a)pyrene enters the atmosphere per year. It is shown that the contribution of autonomous heat supply sources to atmospheric pollution is more than 95%, and that of KrAP is about 3%.
CHARACTERISTICS OF THE FAUNA OF GROUND BEETLES (COLEOPTERA, CARABIDAE) IN THE WESTERN PART OF THE FOREST-STEPPE ZONE OF THE RYAZAN REGION
Authors: Трушицына О.С. , Марочкина Е.А.
Published: May 2023

Фауна жужелиц западного участка лесостепной зоны Рязанской области насчитывает 54 вида из 29 родов. Зоогеографический состав характеризуется господством видов с широкими ареалами. Среди экологических групп преобладают лесо-болотные и лугово-полевые виды жужелиц. Набор зоогеографических и экологических групп типичен для средней полосы России и отражает географические особенности района исследования. Зоофаги преобладали над миксофитофагами.

The fauna of ground beetles in the western part of the forest-steppe zone of the Ryazan region included 54 species representing 29 genera. The zoogeographic composition was characterized by the dominance of species with wide ranges. Forest-bog and meadow-field species of ground beetles predominated among the ecological groups. Zoogeographic and ecological groups were typical for central Russia and reflected the geographical features of the studied area. Zoophagous forms prevailed over mixophytophagous.
CHINESE UNMANNED AERIAL VEHICLES WITH PISTON ENGINES
Authors: Кузнецов Г.А. , Мальков А.Д. , Гильмияров М.Р.
Published: May 2023

В статье проведен анализ китайских беспилотных летательных аппаратов (БЛА) с поршневыми двигателями (ПД). Определены основные тенденции развития БЛА. Отмечен резкий рост количества военных БЛА с ПД за последние двадцать лет.

The article analyzes Chinese the unmanned aerial vehicles (UAVs) with piston engines (PEs). The main trends in the development of UAVs are determined. There has been a sharp increase in the number of military UAVs with PEs over the past twenty years.
HIGH WATER VEGETATION OF LAKE GIRYAL
Authors: Раченкова Е.Г.
Published: May 2023

В растительном покрове озера Гирьял выявлено 13 формаций, которые объединяют 16 ассоциаций. Растительность сообществ характеризуется бедностью видового состава и относительной простотой строения.

In the vegetation cover of Lake Giryal, 13 formations were identified, which unite 16 associations. The vegetation of communities is characterized by poor species composition and relative simplicity of structure.
НОВЫЕ ТЕХНОЛОГИИ В ЭКОЗАЩИТНОМ СТРОИТЕЛЬСТВЕ
Authors: Шершнева М.В.
Published: May 2023

В статье рассмотрена проблема разработки экозащитных технологий в строительстве. Показано, что одним из перспективных направлений может быть создание строительных конструкций, обладающих экозащитными функциями. В статье приведены результаты по определению нефтеемкости пенобетонов различной плотности и по исследованию кинетики поглощения нефтепродуктов.

The article considers the problem of developing eco-protective technologies in construction. It is shown that one of the promising areas can be the creation of building structures with eco-protective functions. The article presents the results of determining the oil capacity of foam concrete of various densities and the study of the kinetics of absorption of petroleum products.
FORECASTING WASTE DISPOSAL IN NEW BUILDING TECHNOLOGIES
Authors: Шершнева М.В.
Published: May 2023

В статье рассмотрена проблема прогнозирования утилизации отходов в строительных технологиях. Показано, что прогноз взаимодействия отходов с загрязнениями окружающей среды может быть положен в основу классификации отходов по признаку экозащитности. В работе приведены данные по оценки экозащитности ионов тяжелых металлов и кальциевых силикатных отходов.

The article considers the problem of forecasting waste disposal in construction technologies. It is shown that the forecast of the interaction of waste with environmental pollution can be used as the basis for the classification of waste on the basis of environmental protection. The paper presents data on the assessment of the environmental protection of heavy metal ions and calcium silicate waste.
THE EFFECTIVENESS OF THE USE OF VARIOUS TREATMENT REGIMENS FOR CHRONIC OBSTRUCTIVE PULMONARY DISEASE WITH BRONCHODILATORS
Authors: Чижиков А.А. , Мерданова М.М. , Магомедова А.Г. , Магадова Г.М. , Шапиева Х.З.
Published: May 2023

Заболеваемость патологией лёгких – одна из самых важных проблем современного здравоохранения. В результате технического прогресса дыхательная система человека подвергается воздействию различных вредных факторов. Весомый процент среди всех заболеваний лёгких составляет хроническая обструктивная болезнь лёгких (ХОБЛ), вызывающая необратимые изменения, как морфологические, так и функциональные. Для её лечения используются различные методы, одним из ведущих является фармакотерапия бронхолитиками. Однако важное значение имеет подбор препарата, а также, в случае необходимости, комбинация лекарственных средств с разными механизмами действия для более эффективного и безопасного применения. В данной статье мы попытались оценить, какая из схем лечения оказывает лучший терапевтический эффект у больных с ХОБЛ.

The incidence of lung pathology is one of the most important problems of modern healthcare. As a result of technological progress, the human respiratory system is exposed to various harmful factors. A significant percentage of all lung diseases is chronic obstructive pulmonary disease (COPD), which causes irreversible changes, both morphological and functional. For its treatment, various methods are used, one of the leading ones is pharmacotherapy with bronchodilators. However, the selection of the drug is important, as well as, if necessary, a combination of drugs with different mechanisms of action for more effective and safe use. In this article, we tried to evaluate which of the treatment regimens has the best therapeutic effect in patients with COPD.
THE ICE SURFACE MATHEMATICAL MODELING IN RELATIVE TO THE ICING EFFECT ON THE AIRCRAFT AERODYNAMIC CHARACTERISTICS STUDY
Authors: Внук В.В. , Левицкий А.В. , Николаев П М. , Никуленко А.А. , Шардин А О. , Юстус А А.
Published: May 2023

Приводятся результаты математического моделирования поверхностей наледей. Приведено описание нескольких разработанных алгоритмов формирования зернистости внешней поверхности. На образцах показана эффективность используемых производственных технологий для изготовления имитаторов обледенения.

The results of mathematical modeling of icing surfaces are presented. A description of several developed algorithms for the formation of graininess of the outer surface is given. The samples show the effectiveness of the production technologies used for the manufacture of icing simulators.
ФОРМИРОВАНИЕ РЕКОМЕНДАЦИЙ ДЛЯ МАГИСТРАЛЬНЫХ И РЕГИОНАЛЬНЫХ САМОЛЕТОВ ПО РАЦИОНАЛЬНОМУ ПРИМЕНЕНИЮ ПРОТИВООБЛЕДЕНИТЕЛЬНОЙ СИСТЕМЫ
Authors: Гаджимагомедов Г.Г. , Николаев А А. , Богатырев В.В.
Published: May 2023

Приводится краткий обзор авиационных правил, используемых в настоящее время сертификации самолетов транспортной категории. Рассмотрены нормированные условия обледенения и критические формы ледяных наростов на аэродинамических поверхностях самолетов, применяемые в качестве основы для рассмотрения возможности их безопасной эксплуатации в этих условиях. Показана возможность сокращения программы сертификационных полетов за счет повторного использования имитаторов льда критической формы. Приводится обзор и особенности противообледенительных систем, получивших наибольшее распространение для магистральных и региональных самолетов.
Shiva danse à travers l’espace et le temps
Authors: Beltz Johannes
Published: May 2023

L’article explore la question de la présentation d’images icôniques considérées comme religieuses dans les collections des musées suisses, ainsi que dans le matériel pédagogique de l’école publique. En prenant pour exemple l’image de Shiva sous sa forme de seigneur de la danse, il montre comment un objet de culte médiéval du sud de l’Inde est devenu l’une des icônes les plus importantes de l’hindouisme actuel. L’article retrace comment cette réinterprétation a eu lieu et quels acteurs y ont été impliqués. Il soutient la thèse selon laquelle les musées tout comme l’enseignement des religions dans l’éducation publique ne devraient pas attribuer une signification unique aux objets, mais devraient au contraire mettre davantage l’accent sur l’évolution de leur signification au fil du temps. Ce faisant, le discours public des musées et des écoles sur ces objets devrait aborder explicitement les phénomènes d’appropriation et de démarcation culturelles, et prendre en compte les publics en tant qu’acteurs potentiels interagissant avec les objets. L’histoire de l’image de Shiva, seigneur de la danse, se poursuit ; elle est loin d’être terminée.
Des objets religieux et des élèves sujets
Authors: Gerber Vital
Published: May 2023

Que permettent des objets religieux dans une salle de classe de gymnase ou de lycée ? Le présent article, à partir de l’exemple d’une exposition d’objets religieux amenés en classe par des élèves (école de maturité, secondaire 2), interroge les implications pédagogiques plus générales d’un tel travail sur des objets ainsi que des pistes herméneutiques qui peuvent les prolonger. En s’intéressant notamment aux travaux de Meirieu, Eco et Ricœur, il reprend la question de l’articulation entre objectivité et subjectivité en didactique des sciences des religions.
Eine Analyse der Präsentation islamischer Objekte im Museum im Kontext von space, place und education
Authors: Eskandaripour Pardis
Published: May 2023

Das Museum ist ein Ort zum Staunen und Lernen. Letztere Eigenschaft teilt es sich mit der Schule, der Bibliothek, dem Hörsaal oder dem Kinderzimmer. Das Museum wird von solchen Orten durch seine Materialität herausgehoben. Jedes Museum basiert auf einer Sammlung von Objekten, die es dem Besucher näherbringt, unter anderem mit dem Ziel, die damit verbundene Kultur zu vermitteln. Im Rahmen der Vermittlung einer fremden Kultur tritt die Besonderheit hinzu, dass auf keine bereits bestehenden originären Überlieferungen gebaut werden kann, welche den Objekten einen adäquaten Kontext zu verleihen mögen. Anhand zweier Objekte aus einer islamisch geprägten Kultur werden Herausforderungen bei der Präsentation muslimischer Kulturen, sowie bei der Erkennung und Kategorisierung von islamischen (religiösen) und islamicate (nicht religiösen) Objekten im Museum aufgezeigt. Mit dem Storytelling wird eine Methode vorgeschlagen, mit welcher Aspekte von Religion und Kultur für Museumsbesucher, besonders Kinder und Jugendliche, beschrieben bzw. vorgestellt werden könnte.
Religiöse Objekte im religionskundlichen Unterricht
Authors: Mägli Lea Sara
Published: May 2023

Die Arbeit mit religiösen Objekten ist ein integraler Bestandteil religionskundlichen Unterrichts. Im Umfeld Schule werden religiöse Objekte jedoch ihrem ursprünglichen Kontext entzogen und stehen so erklärungsbedürftig im Raum. Dieser Artikel geht der Frage nach, wie in der Schule eine lernfördernde Rekontextualisierung religiöser Objekte aussehen könnte und welche Kompetenzen im Rückbezug auf den Lehrplan 21 mit dem Einsatz im Unterricht angestrebt werden können. Wie hier aufgezeigt wird, gilt es aus religionswissenschaftlicher Sicht dabei einige Problematiken zu umgehen. Anschliessend werden mögliche Vorschläge für eine religionswissenschaftlich informierte Arbeit mit religiösen Objekten im Unterricht gemacht, die den Rückbezug auf den Umgang mit, sowie die Bedeutung von, religiösen Objekten für Praktizierende in den Vordergrund stellen. Des Weiteren soll deren Viel- und Uneindeutigkeit thematisiert werden, um essentialisierende Zuschreibungen zu vermeiden. Dieses Vorgehen kann eine vielschichtige Begegnung mit den Objekten ermöglichen, damit diese nicht „strangers in a strange land“ bleiben.
Objekte nähren?
Authors: Wodiunig Scherrer Tina
Published: May 2023

Ausgehend von einer im Museum durchgeführten Zeremonie mit einem indigenen Künstler aus Kanada geht der Artikel der Frage nach, wer oder was im Sinne der Akteur-Netzwerk-Theorie von Bruno Latour im vorgestellten Beispiel die Akteure sind und was das Seelenkonzept der Ojibwa darüber hinaus für zusätzliche Erkenntnisse bereithält. Der Artikel plädiert für einen mehr-perspektivischen Ansatz bei der Arbeit mit Objekten, wobei es gilt, die jeweiligen Perspektiven sorgfältig zu klären. Eine transparente Kontextualisierung der Objekte, scheint insbesondere bei der Arbeit mit aussereuropäischen zeremoniellen Objekten, die sich nicht von selbst erschliessen, im Museum und in der Schule als sinnvoll und notwendig. Latours Grundsatz, den Akteuren zu folgen, erwies sich im konkreten Fall als gewinnbringend und kann auch auf die Schule übertragen werden.
Design of antimicrobial peptides containing non-proteinogenic amino acids using multi-objective Bayesian optimisation
Authors: Murakami Yuki , Ishida Shoichi , Demizu Yosuke , Terayama Kei
Published: May 2023

Antimicrobial peptides (AMPs) have attracted attention as next-generation antimicrobial drugs. Designing AMPs while considering multiple properties, such as antimicrobial activities and toxicity, requires numerous trials and errors by chemists. In this study, we propose MODAN, a machine learning-assisted AMP design framework based on multi-objective Bayesian optimisation. The primary advantage of MODAN is its ability to handle various non-proteinogenic amino acids, which have recently shown the potential of the activity enhancement, and this flexibility has not been achieved by previous works. In addition, multi-objective Bayesian optimisation enables simultaneous improvement of antimicrobial activity and toxicity. We have succeeded in designing peptides that have potent antimicrobial and low haemolytic activities within two rounds of MODAN recommendation and experimentation, based on a strategy that chemists do not usually consider.
Constructing All-Carbon Quaternary Centers from Ketones via Titanacyclobutanes: Rapid Access to Azaspiro[3.n]alkanes
Authors: Weinhold Tyler , Law James , Frederich James
Published: May 2023

Quaternary carbon centers pose a significant challenge in chemical synthesis. Harnessing the underexplored reactivity of titanacyclobutane intermediates, a strategy to construct functionalized all-carbon quaternary centers from ketones is described. This methodology streamlines access to a wide variety of azaspiro[3.n]alkanes that have emerged as valuable three-dimensional inputs for drug discovery.
Switching Singlet Exciton to Triplet for Efficient Pure Organic Room-Temperature Phosphorescence by Rational Molecular Design
Authors: Ma Liangwei , Liu Yiwei , Tian He , Ma Xiang
Published: May 2023

The design and regulation of phosphor are attractive but challenging due to the spin-forbidden intersystem crossing (ISC) process. Here, a new perspective on the enhancement of ISC was proposed and demonstrated. Different from current strategies, the ISC yield (ΦISC) was enhanced by decreasing the fluorescence radiative transition rate constant (kF) via rational molecular designing, rather than boosting the spin-orbit coupling by decorating molecular skeleton with heavy atom, heteroatom, or carbonyl. The kF of the designed molecule in this case was associated with the substituent position of the methoxy group, which alter the distribution of the front orbitals. The S0→S1 transition of these compounds evolved from bright state to dark state gradually with the variation of substituent position, accompanied by the decrease of kF and increase of ΦISC. The fluorescence emission was switched to phosphorescence emission successfully by regulating the kF. This work provided an alternative strategy to design efficient room-temperature phosphorescence material.
An Assay for Aryl Radicals Using BHAS Coupling
Authors: Murphy John , Clark Kenneth , Tyerman Seb , Evans Laura , Robertson Craig
Published: May 2023

Aryl radicals are intermediates in many reactions, but determining their presence unambiguously is often challenging. As we recently reported, reaction of 2-iodo-1,3-dimethylbenzene 7 in benzene with KOtBu and a suitable organic additive, leads to a base-induced homolytic aromatic substitution (BHAS) coupling reaction giving 2,6-dimethylbiphenyl 12 and biphenyl 3 as coupled products, together with xylene. Biphenyl arises from a radical translocation and is the major coupling product. This paper now investigates that reaction, using deuterium isotope studies to provide detailed mechanistic support. The reaction gives very similar outcomes with two different radical generation sources, and in doing so, shows its ability to act as an assay for aryl radicals. An advantage of such a BHAS process is that it involves a chain reaction that can amplify radical activity.
Identification of compounds from natural Peruvian sources as potential inhibitors of SARS-CoV-2 Mpro mutations by virtual screening and computational simulations
Authors: Barazorda Ccahuana Haruna Luz , Goyzueta Mamani Luis Daniel , Cárcamo Rodriguez Eymi Gladys , Centeno Lopez Angela Emperatriz , Paco Chipana Margot Inés , Chávez Fumagalli Miguel Angel
Published: May 2023

The COVID-19 pandemic continues to be a public health problem worldwide. Several therapeutic targets of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been identified, whereas the main protease (Mpro) is necessary for virus replication. Since SARS-CoV-2 Mpro mutation rates are inherently high, searching for new inhibitors remains challenging. Herein, this work aimed to evaluate eighty-four natural compounds from Peruvian sources against different mutations on the Mpro target. Using computational technics, we applied virtual screening, all-atom molecular dynamics simulations, and binding free energy estimation by MM/GBSA methods. The virtual screening results helped us identify rutin as the top compound against different Mpro mutations. Likewise, the computational simulations demonstrated the high structural stability of the Mpro-rutin system. Our results demonstrated the antiviral capacity of compounds from Peruvian sources against SARS-CoV-2 Mpro and its mutations, which could significantly prevent and treat SARS-CoV-2 infection.
REGULAÇÃO DO SETOR ELÉTRICO: ENTRE MONOPÓLIOS E LIBERDADE DE CONTRATAÇÃO
Authors: Bacellar Roberto Ramos , Gonçalves Oksandro Osdival
Published: May 2023

A energia elétrica é essencial ao exercício de basicamente qualquer atividade humana. O estudo das relações jurídicas e econômicas do setor mostra-se de suma relevância: a eficiência econômica de diversas atividades econômicas depende diretamente da própria eficiência econômica do setor elétrico. Considerando-se a complexidade das relações, instituições e as especificidades do setor de energia, as ferramentas tradicionais do Direito já não se mostram suficientes para a adequada análise da questão. Diante disso, o presente artigo visa abordar os pontos de interseção entre Economia e Direito na regulação do setor de energia elétrica nacional, identificando os impactos da regulação, especialmente nos casos em que, dela, resultam monopólios e restrições à liberdade de contratação. Para tanto, parte-se da análise do seu contexto regulatório, identificando os agentes reguladores e os objetivos da regulação. Utilizando instrumentos da Análise Econômica do Direito, passa-se a analisar aspectos pontuais da regulação concernentes a monopólios que, por mecanismos do mercado, acabam gerando restrição à liberdade de contratação e acarretam consequente ineficiência econômica. Busca-se, assim, identificar falhas de mercado e falhas institucionais que, de alguma maneira, restrinjam a eficiência econômica setorial, buscando alternativas e soluções para a eliminação dessas falhas e a obtenção da melhor eficiência econômica.
USO DA TECNOLOGIA PARA FINS ILÍCITOS: A VIOLAÇÃO DA INTIMIDADE POR MEIO DE CRIMES INFORMÁTICOS
Authors: Giolo Júnior Cildo , Aylon Lislene Ledier
Published: May 2023

O presente artigo tem como objeto de pesquisa os crimes informáticos quando violam a intimidade das pessoas, visando compreender como a internet, ao mesmo tempo em que facilitou a vida dos seres humanos, trouxe uma total invasão à sua privacidade, com a prática de delitos antes dela inimagináveis. Inicialmente, foi analisado o direito à intimidade, garantido pela Constituição Federal e por leis ordinárias. Em seguida, adentrou-se ao estudo da Informática, com o surgimento da internet e dos crimes informáticos, em seus aspectos técnicos e a legislação pátria pertinente. Por fim, chegou-se à análise da violação da intimidade praticada por meios virtuais. Após todas essas etapas, verificou-se ser insuficientes as leis que existem no Brasil, capazes de conter os avanços da criminalidade virtual.
AGENDA PENDIENTE DE LOS AMICI CURIAI. ANÁLISIS A LA LUZ DE LOS DERECHOS FUNDAMENTALES
Authors: Manrique Jorge Isaac Torres
Published: May 2023

La institución juridica del amicus curiae no presenta el reconocimiento legal ni constitucional, en no pocos países, consecuentemente su desarrollo, ni su uso no es el esperado.En la presente entrega, en primer término el autor aborda dicha temática, para luego formular los puntos que requieren ser de urgente como insoslayable atención, a efectos que la misma alcance sus fines.
LIMITES JURISPRUDENCIAIS PARA A INSTITUIÇÃO DA CONTRIBUIÇÃO DE MELHORIA
Authors: Ferreira Junior Rubens , Favacho Fernando Gomes , Martos Frederico Thales de Araújo
Published: May 2023

O presente artigo faz uma releitura da Contribuição de Melhoria enquanto tributo essencial para compor o equilíbrio fiscal. Inicialmente fez-se um retrospecto das origens do tributo, retroagindo às ordenações filipinas, enquanto Brasil colônia até os dias atuais. Se estabeleceu os limites jurisprudenciais específicos e legais, e a subutilização do instituto, tendo em vista a dificuldade em se aferir os parâmetros estabelecidos em lei para sua instituição bem como o valor da obra / valorização imobiliária. Estabeleceu-se ainda a necessidade ou não de sua instituição frente a lei de responsabilidade fiscal e a possibilidade de instituição de outros requisitos previstos na jurisprudência.
Kaynaştırma Eğitiminde Öğretmen Yeterliliklerinin İncelenmesi: Anaokulu Öğretmenleri Üzerine Bir Araştırma (Investigation of Teacher Qualifications in Inclusive Education: A Research on Kindergarten Teachers)
Authors: Topçuoğlu Fatih , Topçuoğlu Sibel , Türk Metin , Çalışkan Tuncay
Published: May 2023

Kaynaştırma eğitimi, genel itibariyle özel gereksinimli bireylerin normal gelişim gösteren akranlarıyla aynı sınıf ortamında eğitim görmesini içermektedir. Böylece kaynaştırma öğrencisi, kendi akranlarıyla sosyal kazanımlar elde edecektir. Ancak kaynaştırma eğitiminde öğretmen yeterliliği önemli bir rol üstlenmektedir. Araştırmanın amacı, okul öncesi öğretmenlerin kaynaştırma eğitimine ilişkin yeterlilikleri üzerinedir. Bu doğrultuda ilk olarak, sınıfında kaynaştırma öğrencisi olan ve olmayan öğretmenlerin kaynaştırma eğitimine ilişkin görüşlerinde farklılık olup olmadığı incelenmiştir. İkinci olarak, kaynaştırma eğitimi alan ve almayan öğretmenlerin kaynaştırma eğitimine ilişkin tutumları arasında farklılık olup olmadığı incelenmiştir. Araştırma nicel araştırma deseni ile tarama modelinde yürütülmüştür. Bu doğrultuda çalışmanın evrenini Ankara ilinde Millî Eğitim Bakanlığına bağlı bağımsız anaokullarında ve ilkokul ve ortaokula bağlı anasınıflarında görev yapan kadrolu okul öncesi öğretmenleri oluşturmaktadır. Kayıtlı kaynaştırma öğrencisi olan okullar, araştırma evreninin seçiminde kriter olarak seçilmiştir. Araştırma verilerinden elde edilen sonuçlarına göre öğretmenler, kaynaştırma eğitiminden başarılı bir sonuç elde edilmesinde aile çevre ve personeli bilgilendirilmesi gerektiğine vurgu yapmaktadır. Öğretmenlerin kaynaştırma eğitim durumuna göre kaynaştırma yeterliliklerinde anlamlı bir farklılık elde edilmemiştir. Ayrıca sınıfında kaynaştırma öğrencisi bulunma durumuna göre kaynaştırma yeterliliği istatistiksel olarak bir farklılık oluşturmamaktadır.
Postmodernizm ve Erkeklerin Değişen Beden İmajları: Kuşaklar Arası Bir Çalışma (Postmodernism and Men s Changing Body Images: An Intergenerational Study)
Authors: Güneş Yüce Tuğçe , Tor Hacer
Published: May 2023

Cinsiyet, bireylerin biyolojik cinsiyete göre ayrılması iken; toplumsal cinsiyet, toplumsal rol ve sorumlulukların bireylerin cinsiyeti baz alınarak toplum tarafından oluşturulmasıdır. Postmodernizm, toplum kültürünün etkisi ile bireyin bedeni ve görünüşünün zihinde yarattığı resim olan beden imajı kavramlarında zamanla değişiklikler gözlemlenmektedir. Bu çalışma, postmodernizm ile erkeklerin değişen beden imajlarını kuşaklar arası farklılıklar üzerinden ortaya çıkarmak amacıyla planlanmıştır. Bu amaca ulaşılması için kişisel bakım, giyim-kuşam, aksesuar, beslenme ve spor kategorilerine ilişkin veriler nitel araştırma yöntemi kullanılarak toplanmıştır. Araştırmada X, Y ve Z kuşaklarından 5’er kişinin araştırmaya katılması ile toplam 15 kişiyle yapılandırılmış ve yarı-yapılandırılmış soru formları ile derinlemesine görüşmeler yapılmış, veriler MAXQDA programı ile içerik analiz tekniği kullanılarak analiz edilmiştir. Araştırma sonucunda, X ve Y kuşaklarının beden imajına ilişkin pratikleri ve yorumları daha çok benzerlik gösterdiği; Z kuşağında postmodernizmin etkisi ile toplumsal cinsiyet rol ve normlarını yorumlamaları, tüketim kalemleri, beden imajlarına yönelik bakım ve aksesuarpratiklerinde diğer kuşaklara göre farklılıklar olduğu görülmüştür. Bu çalışma Prof. Dr. Hacer TOR’un danışmanlığında Tuğçe GÜNEŞ YÜCE tarafından hazırlanan “Postmodernizm ve Orta Sınıf Erkeklerin Değişen Beden İmajları: Kuşaklar Arası Bir Çalışma” başlıklı yüksek lisans tezinden üretilmiştir.
N. S. Leskov un “Büyülü Gezgin”(Очарованный Странник) Adlı Eserinin Metinlerarasılık Bağlamında İncelenmesi (An Analysis of N. S. Leskov s Work “The Enchanted Wanderer” (Очарованный странник)in the Context of Intertextuality)
Authors: Ilıca Sevgi
Published: May 2023

Nikolay Semyonoviç Leskov (1831-1895) XIX. yüzyıl Rus edebiyatının önde gelen gerçekçi yazarlarından biridir. Yazar 1873 yılında kaleme aldığı Büyülü Gezgin (Очарованный странник)adlı öyküsünde dönem Rusya’sının ve yerel Rus halkının gerçekçi tablolarını sunar. Leskov zengin kelime dağarcığı, geniş yerel diyalekt spektrumu, muazzam bilgi birikimi ve eşsiz yazın yeteneğiyle Rus topraklarının kültürel ve etnik çeşitliliğini gözler önüne serer. Bu çalışma Leskov’un bahsi geçen eserinde yer alan alıntı ve göndergeleri metinlerarasılık kuramı çerçevesinde incelemeyi amaçlar. Bu bağlamda ilkin Julia Kristeva başta olmak üzere bu alanda öne çıkan edebiyat kuramcılarının savları doğrultusunda metinlerarasılık kavramı tanımlanır. Sonuçta Leskov’un öyküsünde bilhassa Rus millî kimliğini ve Ortodoksluğu ön plana çıkaracak metinlere gönderme yaptığı gözlemlenir
1982 Anayasasında 2010 Tarihine Kadar Yapılan Değişiklikler (Amendments Made in the 1982 Constitution Until the Year 2010)
Authors: Kılıç Fethi , Yalçın Atalay Nurhan
Published: May 2023

Gelişen toplumsal olaylar ve anarşik ortamın yaygınlaşması ile Türk Silahlı Kuvvetleri 12 Eylül 1980 günü yönetime el koymuştur. Toplumsal düzenin sağlanması ve demokratik ortamın oluşması için toplumun ihtiyacı olan Anayasa yapma ihtiyacı olduğu kararlı bir biçimde kamuoyu ile paylaşılmıştır.Danışma Meclisi bünyesinde Anayasa Komisyonu oluşturulmuş ve oluşturulan komisyonun başına Prof. Dr. Orhan Aldıkaçtı getirilmiştir. Anayasa Komisyonunca hazırlanan ve Milli Güvenlik Kurulunun incelemesinden geçen Anayasa metni 7 Kasım 1982 günü yapılan halkoylaması sonucu; %8.63 “RED” oyu verilmiş ve %91.37 “KABUL” için oy verilerek kabul edilip, 9 Kasım 1982 tarihinde yürürlüğe girmiştir.1982 Anayasası, 1961 Anayasası ile getirilen hak ve özgürlüklere bir tepki olarak, hak ve özgürlükleri sınırlamayı seçmiştir. Ayrıca yaşanan parlamenter rejimin tıkanıklıklarını gidermek için; Cumhurbaşkanına parlamenter rejimde olmayan V. Fransız Anayasasından esinlenerek Yarı Başkanlık Rejimindeki, Cumhurbaşkanlığı yetkileri verilmiştir.Çalışmamızda 1982 Anayasasında 2010 tarihine kadar yapılan değişiklikleri ve getirilen yeni düzenlemeleri; Anayasa Hukuku ve Siyaset bilimi açısından inceleyeceğiz.
Establishing Molecular Biology Tools for Phytophthora agathidicida
Authors:   , Hayhurst Max
Published: May 2023

Phytophthora – Greek for “the plant-destroyer” – is a genus of eukaryotic microorganisms that cause devastating plant diseases worldwide. Collectively, Phytophthora species cause billions of dollars in damages to crops and native ecosystems annually. Despite these extensive impacts, Phytophthora research is challenging due to a lack of molecular biology tools. Widely used techniques such as transformation and gene deletion remain challenging to establish in Phytophthora species. However, CRISPR-Cas genome editing was recently achieved in a small number of model Phytophthora species – but these breakthroughs have yet to reach most members of the genus. The pathogen Phytophthora agathidicida is one example. P. agathidicida causes kauri dieback, a disease that threatens kauri, one of our most important tree species in New Zealand. P. agathidicida was formally named in 2015 and is therefore an emergent threat. Consequently, key molecular methods such as transformation and CRISPR-Cas genome editing have yet to be established for this pathogen.

The overarching goal of this thesis was to establish molecular biology methods for the study of P. agathidicida. The first aim was to identify a suitable target for genome editing with CRISPR-Cas and design guide RNAs for the target. A putative thymidine kinase gene from the P. agathidicida isolate 3770 genome was selected as a target, and eight guide RNA sequences were designed. All of the guide RNAs successfully directed the digestion of the target gene in vitro. The second aim was to establish a method to produce and transform P. agathidicida protoplasts. An optimised recovery medium was identified using a mock transformation method, which increased protoplast germination rates from 2.4% in a previously used medium to 15% in the new medium. Using the optimised conditions, P. agathidicida was transformed with plasmids encoding Cas nuclease-GFP fusion proteins. Transformants were both fluorescent and antibiotic resistant. The third aim was to express, purify, and characterise the putative thymidine kinase enzyme. Yeast species Pichia pastoris was used as a protein expression host, but neither protein expression nor kinase activity were consistently observed.

In this thesis, P. agathidicida was successfully transformed for the first time. Transformation is a huge advancement and will greatly accelerate molecular biology research in P. agathidicida for years to come. In particular, transformation is a key step towards CRISPR-Cas genome editing in P. agathidicida. CRISPR-Cas will not only provide insights into its fundamental biology, but may guide the development of new control strategies for this devastating pathogen.
Empirical Essays on Corporate Venture Capital, Financial policies, and Liquidity Management
Authors:   , Tawiah Bernard
Published: May 2023

This thesis is composed of three self-contained empirical essays in entrepreneurial financeand corporate finance, with the first two exploring the effect of corporate venture capitalinvestments on financial policy and dividend payout. The third examines the impact ofCOVID-19 on corporate investment and how cash holdings reduce the impact. Firms invest in corporate venture capital (CVC) for strategic reasons. Consistent with maintaining financial flexibility to fund CVC driven innovation and acquisitions, in Essay one, we find that CVC investing firms hold less debt and more cash. Our results are morepronounced among the highest CVC investors and strategically driven CVC investors assuch firms maintain the most conservative financial policies. CVC firms are more likely toacquire using cash and this relationship is more pronounced among strategic CVC firms.

Overall, our results are consistent with studies that advance that firms with growth orinvestment opportunities maintain financial flexibility.

Consistent with the signaling theory that firms usually pay cash dividend to signalpositive prospects, Essay two finds that CVC investors pay higher dividends compared tonon–CVC firms. Specifically, CVC investment leads to a 9% increase in dividend payout.

The results show that the relationship between CVC investment and dividend is driven bystrategic CVC investors. There is no statistically significant relationship between CVCand dividend for financially oriented CVC firms. Possible channels that influence therelationship between CVC investment and dividend payout are future profitability andearnings. In the third essay, using the COVID-19 pandemic as an exogenous shock, we examinethe impact of cash holdings on corporate investment during the COVID-19 pandemic.

We find that Capital Expenditure and M&A levels decrease by 37% and 71% respectivelyduring the COVID-19 pandemic. However, the impact of COVID-19 on investment is lessfor firms with accumulated cash. Firms at the 81st percentile of cash holdings maintaincapital expenditure and acquisition at pre-COVID-19 levels. Overall, our evidence showsthat the COVID-19 pandemic has had an adverse effect on corporate investment activities,but accumulated cash holdings reduce the impact.
Chemical Investigations of Pacific Marine Organisms
Authors:   , Bracegirdle Joe
Published: May 2023

This thesis describes a comparative study of three screening methods for the discovery of new marine natural products (MNP) from South Pacific organisms. Over the course of the study, 13 tunicates, one bryozoan and one red alga collected from the waters of the Kingdom of Tonga and New  Zealand were investigated. Bioassay, ¹H nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS) were used to prioritise six organisms for investigation, which resulted in the isolation and characterisation of 16 new and 11 previously reported metabolites.    

An NMR–based spectroscopic screening protocol led to the isolation of  the new cyclic polyhalogenated monoterpene costatone C (46), isolated from a NZ red alga identified as Plocamium angustum, which showed moderate antibacterial activity. The absolute configuration of a previously reported and co–isolated bis–normonoterpene (47) was also deduced using Mosher’s method. The NMR screening protocol also  prioritised the Tongan bryozoan Nelliella nelliiformis, from which the nucleosides nellielloside A and B (61 and 62) were isolated and inspired the synthesis of congeners 66–69. All six compounds showed potent kinase inhibitory activity against a subset of disease–relevant kinases, with IC50 values determined to be in the nM range for GSK3A, MAPK14 and RSK2.    

An MS screening protocol was also employed utilising molecular networking through the GNPS platform. Of the eight tunicates examined, three were further investigated based on promising constellations in the network, and collectively led to the identification of 13 new compounds. A new aromatic ketone (28) was isolated from the NZ tunicate  Distaplia stylifera, while a comprehensive examination of a NZ Synoicum kuranui sample resulted in two new compounds, rubrolides T and U (110 and 111). The encrusting tunicate Didemnum ternerratum was the most fruitful organism examined in this work, resulting in the isolation of ten new and three previously reported lamellarin sulfates (147–151 and 153–156). The absolute configurations of atropisomers 148–151 were  determined by comparison of experimental and calculated ECD spectra. Compound 151 showed moderate cytotoxicity against HCT–116 cells.

This work illustrated the power of molecular networking as a screening tool when applied to the MNP field, particularly for the isolation new derivatives within a previously known family of compounds. It also suggested that the more traditional NMR spectroscopy–based screening protocol is still very useful as a standalone method when no comparative  standards are available. These complementary techniques should be used together to maximise new MNP discovery. 
Learners' Perceptions on the Use of Oral Corrective Feedback in One-to-One EFL Classroom
Authors: Syakira Sitti , Nur Sahril
Published: May 2023

Abstract. Learners’ perception plays an important role in evaluating the teaching and learning process and has an impact to the teacher’s performance during the teaching and learning process. Applying descriptive qualitative method with case study design, this study highlighted the learners’ perceptions and their preference of oral corrective feedback utilized by the teachers during the teaching and learning process. By using purposive sampling, this research involved one teacher and two learners as research participants at an English course called Amsterdam Institute located in Makassar. The data, collected through semi-structured interview and observation, resulted that the learners found themselves facilitated in responding the teacher’s utterances since the teacher’s oral corrective feedback were helpful to lead the learners’ accuracy or just to help them acknowledge their errors in terms of grammar, lexis, the use of L1, and particularly in phonology (pronunciation). Furthermore, inconsistencies between the students’ preference and the teacher’s feedback use in terms of the time to provide oral corrective feedback are identified.  Students preferred being given time to work out their error, while teacher mostly gave feedback directly. Thus, it can be concluded that giving more time for students to provide self-repair can be a way for students to make sense of error they committed. The results further highlight a significant impact for teachers’ beliefs on their corrective feedback practices, especially for those teaching using a tailor-made system. Finally, the implication of this study is discussed.Keywords: Learners’ Perceptions, Oral Corrective Feedbacks, One-To-One EFL Classroom.
The Needs of English Culinary Booklet to Support Domestic and Foreign Promotion at the South Sumatra Culture and Tourism Office
Authors: Monika Mona , Inderawati Rita , Eryansyah Eryansyah
Published: May 2023

Abstract. This research aimed to determine the Domestic and Foreign Promotion at the South Sumatra Culture and Tourism Office needs in booklet development based on South Sumatra culinary. The data were obtained through the use of a questionnaire and semi-structured interviews. The sample of this study was stakeholders’ and staff at South Sumatera Culture and Tourism office. The data were analyzed both quantitatively and qualitatively. The needs analysis performed included TSA, deficiency analysis, PSA, and strategy analysis. The result of the need analysis showed that: 1) booklet material was important to support the region’s promotion. 2) developed English culinary booklet is important to help South Sumatra promote well because most of its employees already have an intermediate level of English. 3) Booklets that are remade only once a year with almost the same topic and only updated. 4) Integrating a culinary booklet was needed since there was only a booklet related to South Sumatera in general. 5) Integrating the Traditional Culinary Booklet of South Sumatra could encourage the awareness to learn traditional culinary of South Sumatra. 6) Most readers needed to learn the South Sumatera culinary booklet related to the main course, Dessert and Appetizer. 7) The readers prefer it will be using easy-to-understand language, and there is an explanation for difficult terms. Due to the needs, it was necessary to develop an English booklet by integrating South Sumatra culinary, which can support domestic and foreign promotion at the South Sumatra Culture and Tourism Office.Keywords: English Culinary Booklet, Tourism, Needs Analysis