bluuebunny/crossref_metadata_2025 huggingface dataset:
GENE SERPINA1: POTENCIAL MARCADOR DIAGNÓSTICO EM CARCINOMAS PAPILÍFEROS DA TIREOIDE
Authors: Santos Joyce Nascimento , Queiroz João Paulo Da Silva , Medeiros Neto Lázaro Pinto , Santos André Bandiera de Oliveira , Canevari Renata De Azevedo
Published: October 2021

As neoplasias tireoidianas são o principal tipo de malignidade endócrina, sendo atualmente consideradas um problema de saúde pública com aumento constante em sua incidência nos últimos anos. A descoberta de marcadores moleculares que possam ser aplicados na rotina clínica em conjunto com a biópsia por aspiração com agulha fina (PAAF) pode propiciar um diagnóstico mais preciso e consequentemente um tratamento mais eficiente para o paciente. O objetivo desse estudo foi avaliar se o gene SERPINA1 pode ser considerado um marcador diagnóstico em carcinomas de tireoide. Foi realizada a análise de expressão gênica pela RT-qPCR, em 32 amostras de tecido tireoidiano, sendo 13 bócios, 11 carcinomas papilíferos, quatro carcinomas foliculares e quatro tecidos não tumorais de tireoide. A expressão aumentada do gene SERPINA1 foi observada nas amostras de carcinoma papilífero em comparação com amostras de bócio (P=0.0319) e com as amostras de carcinoma folicular (P=0.0430). Não foi observada expressão diferencial significativa entre amostras de carcinoma folicular com as amostras de bócio (P= 0.5329). Os resultados da análise de expressão gênica sugerem que o gene SERPINA1 pode ser considerado um marcador diagnóstico em carcinomas papilíferos de tireoide.
Arduino-Based Three-Phase Inverter Using Power MOSFET for Application in Microgrid Systems
Authors:   University of Information Technology and Sciences (UITS), Dhaka-1212, Bangladesh, Chowdhury Imran , Hossain Saroar , Das Niloy Kumar , Ahmed Taslim , Hasan Md. Mahmudul
Published: October 2021

Rapid depletion of fossil fuel reserves, and concerns over climate change have encouraged power generation from sustainable energy based microgrids. And to address the necessity of three-phase inverters in microgrid systems or sustainable-powered households, an Arduino-based three-phase inverter using MOSFET is designed, which converts DC into three-phase AC power. The designed system generates 223V square signals at each phase from a 12V battery through switching of three stages of power MOSFETs using pulse width modulation (PWM) signals at their gates from an Arduino Uno. Each stage of power MOSFETs consists of six transistors making it eighteen in total, which are used to perform the inversion process separately for each three single-phase connections. The system is programmed using an Arduino Uno to generate PWM signals and to keep 120 degrees phase displacement among each phase. Three step-up transformers are coupled at the outputs of MOSFET stages for amplification. The system generates 386.25V of voltage for the three-phase line delivering 0.58A of current using a 60W incandescent bulb at each phase as a load. The design and simulation of the electronic circuit are done by Proteus, and the programming codes are written using Arduino IDE. The designed system is practically contrasted and verified.
Efficacy of eutectic mixture of local anesthetics in alleviating pain associated with lumbar puncture in newborns: a placebo compared randomized controlled trial
Authors: Sharma Akshi , Sharma Rakesh , Sood Mangla , Kumar Pancham
Published: October 2021

Background: Lumbar puncture (LP) is one of the most commonly encountered painful procedure in paediatric medicine. Research has shown that neonates too experience pain from noxious stimuli that can be more intense than what is experienced by an adult, and so have the right to receive safe, efficient and effective pain management. Objective was to determine efficacy of topical eutectic mixture of local anesthetics (EMLA) in alleviating pain associated with lumbar puncture among newborns admitted to sick newborn care unit (SNCU).Methods: The study was a one-year tertiary care teaching hospital-based randomised comparative double blinded trial among 42 neonates aged 32 weeks or more admitted to SNCU and required a diagnostic lumbar puncture, randomly assigned to one of two groups. Half hour before the procedure, 1 g of topical EMLA cream was applied to LP site in intervention group versus placebo in other group. At different stages, the heart rate, transcutaneous oxygen saturation level, and total behaviour score were captured on a video camera and rated using the neonatal facial coding system.Results: EMLA dramatically lowers pain sensitivity when compared to placebo. Total behavioural score means±standard deviation (SD) at the moment of needle insertion (EMLA: 1.05±1.24; placebo: 2.71±1.76, p≤0.001) and post procedural 5 minute later was (EMLA: 0.05±0.22; placebo: 0.81±0.92, p≤0.01). Similarly, oxygen saturation level when needle was in spinal place (EMLA: 96.76±2.45; placebo: 94.29±3.62, p=0.01) and post procedural 1 hour later was (EMLA: 98.81±1.94; placebo: 97.48±2.18, p=0.04). The heart rate of all newborns in both groups was greater than it was at baseline, although the difference was not significant.Conclusions: EMLA is an effective agent in reducing pain associated with LP among newborns.
Usage of antibiotics and monitoring of drug interactions in pediatrics at a tertiary care teaching hospital
Authors: N. Rajasekar , M. Kireesh Kumar , M. Sowndarya , K. Dhanapal C. , R. Ramanathan
Published: October 2021

Background: Respiratory tract infections (RTI) are more common in pediatrics. Especially in developing countries like India, RTI causes more death in children. Antibiotics are used to treat RTI even in case of viral infections. Hence rational use of antibiotics is very much needed to avoid antibiotic resistance. In this study we have analysed the prescribing pattern of antibiotics and their drug interactions involved in the management of respiratory tract infections in a tertiary care teaching hospital.Methods: A prospective observational study was conducted in the department of pediatrics at a tertiary care teaching hospital for a period of 6 months (November 2019-April 2020). A total of 144 patients were included in the study and their prescription was analysed for their antibiotic prescribing pattern and interactions.Results: Infants were more prone to RTI infections. Among RTI, lower RTI were more common in children. We have analysed prescribing pattern of antibiotics in which, mono antibiotic therapy were more commonly used. Ampicillin was the frequently prescribed antibiotic. Azithromycin had the most possible interactions among the antibiotics prescribed.Conclusions: More than 336 antibiotics were used for all types of RTI, even in the case of viral infections. So rational use of antibiotics is needed. Among 144 children who were enrolled in the study, none of them were subjected to culture sensitivity test. As of which, all of them were treated empirically. Penicillin and cephalosporin are the mostly prescribed antibiotics in RTI. Cephalosporin prescribed children had less hospital stay and hardly interactions were found.
A study on impact of iron deficiency on cognition and anthropometry in pediatrics and clinical pharmacist’s intercession to provide awareness about iron deficiency in tertiary care teaching hospital
Authors: V. Aishvarya , P. Roshine , M. Elayarani , P. Mahendravarman , S. Saravanan
Published: October 2021

Background: Micronutrient deficiencies largely affect pediatric population worldwide. In India, pediatric category is more prone to iron deficiency, the most common micronutrient deficiency disorder which produces haematological as well as non-hematological disturbances. This study aimed to identify the impact of iron deficiency on cognitive function and anthropometric changes in pediatric populations.Methods: A hospital based, prospective observational study was conducted at Department of Pediatrics in Rajah Muthiah Medical College and Hospital, 127 participants were enrolled in this study. BKT kit of Intelligence, Electronic weighing machine, Stadiometer, BMI Calculator by CDC guidelines and patient’s haemoglobin values were used in this study.Results: Out of 127 patients, 66 patients had iron deficiency with anemia and remaining 61 had iron deficiency without anemia. Cognitive behaviour was assessed based on the norms and majority were under the category- dull average (52 patients) followed by average (45 patients) and other’s had single digit patients. Growth charts of Indian Academy of Pediatrics were used to assess anthropometric characteristics and majority were in the underweight category (61.4%) followed by average category (38.6 %).Conclusions: Low cognitive scores and underweight were found in participants with low haemoglobin levels. Hence, our study provides convincing evidence that iron plays a vital role in the cognition, motor and physical growth. Awareness about the importance of iron and the health issues associated with its deficiency was also provided to the participants.
Role of iron in breath holding spells and effect of iron therapy in children
Authors: Chesti Mohmad Saleem , Chaman Shilakha , Nazir Mudasir
Published: October 2021

Background: Breath holding spells (BHS) are paroxysmal events resulting from painful stimulus or emotional event resulting in forceful crying, occur in children’s aged between 6 months to 6 years. To assess the role of iron in breath holding spells (BHS) and to assess the efficiency of iron therapy in reducing frequency of BHS.Methods: This was a prospective, interventional study conducted at GMC baramulla. A total of 70 patients between the ages of 6 months and 5 years with breath holding spells with iron deficiency and iron deficiency anemia were studied. After giving them iron therapy for 6 and 12 weeks, they were assessed for the improvement in their anemia and its impact on the frequency of breath holding spells.Results: Seventy children with breath holding spells were studied prospectively. Forty (57.15%) cases were males and 30 (42.85%) females. There was a statistically significant rise in the hemoglobin level, serum ferritin, serum iron with 6 and12 weeks of iron therapy (p<0.001). This rise in the hemoglobin level serum ferritin and serum iron was associated with a statistically significant fall in the frequency of breath holding spells with 6 and 12 weeks of iron therapy (p<0.001).Conclusions: iron supplement is effective in reducing the frequency of breath holding spells and thus iron has role in BHS.
Paediatric anti-GABAB receptor encephalitis associated with SARS-CoV-2 (COVID-19) infection
Authors: Premakumari Nidhi Shivanna , Rudrappa Sudha , Patagar Pratibha Manjunath
Published: October 2021

Though we are approaching the end of second wave of COVID pandemic, we are still unrevealing the various presentation this viral infection can result in. There are few cases reported to have anti NMDA autoimmune encephalitis associated with COVID-19 infection or MIS-C. Here we are reporting one of its variants that was anti-GABAB receptor encephalitis associated with COVID-19 infection. We are reporting a 9 years old female child who was a known case of seizure disorder and on regular medications presented on 4th day of RT-PCR positive status for COVID-19 with complains of convulsions which was managed with antiepileptics. On day 6 of hospitalization she had autonomic instability in the form of tachyarrhythmia, repitation of speech, sudden outburst of laughter and on day 7 child landed in status epilepticus. Autoimmune encephalitis suspected secondary to COVID-19 infection and the child was started on IVIG but not much of improvement seen with this. CSF analysis showed weakly positive anti GABAB antibodies and child had persistently elevated inflammatory markers hence started on high dose corticosteroid. MIS-C ruled out. Child showed drastic improvement both clinical and biochemical after high dose corticosteroids. Prompt treatment with IVIG/corticosteroids have shown a drastic improvement in our child just like in any other autoimmune encephalitis. Though further detailed study is required to prove its exact mechanism in COVID-19 infection, it should be thought of when appropriate and prompt early initiation of therapy will help us reduce morbidity and mortality associated with it.
Aneurysmal bone cyst in the head and neck region of the pediatric patients: a review
Authors: Swain Santosh Kumar
Published: October 2021

Aneurysmal bone cysts (ABCs) are benign, vascular and cystic bony tumors which can be rapidly expanding and locally cause destruction of the surrounding tissue. ABCs in the head and neck area are usually found in patients with younger age group. ABC in the head and neck region of children may vary in presentations and severity.  ABCs are commonly found in mandible, sinonasal tract and cranium in head and neck region. Imaging and histopathological examinations confirm the diagnosis. Complete surgical excision is the treatment of choice. ABC which is secondary to underlying bone pathology like osteoblastoma may refractory to treatment. ABC in the head and neck region are uncommon and should be considered as differential diagnosis of bony and vascular lesions in the locations like mandible, sinonasal area, cranium, mastoid bone and spine. The review article includes case series, case reports and original research on ABCs manifesting in the head and neck area published in the English language. All literatures identified via Scopus, Google scholar, Medline and PubMed were analyzed individually. Articles of ABCs included according to specified eligibility criteria. The total number of articles were 78 (41 case reports; 37 cases series; 8 original articles). ABCs rapidly grow with expansile manner and result in destruction of bone and surrounding tissue in the head and neck region, so clinicians must think about this clinical entity to diagnose correctly and treat appropriately. The aim of the article is providing a comprehensive review of the ABC in the head and neck region of the pediatric patients.
Guía para la mejora de la implementación del Programa "Mi Abrigo"
Authors: García José , Torres Édgar , García Fiorella
Published: October 2021

Con el fin de atender las necesidades de la población más vulnerable de las zonas altoandinas del Perú, que año tras año se ve afectada por el fenómeno de las heladas, el Estado peruano desarrolló el Plan Multisectorial ante Heladas y Friaje 2019-2021. Como parte de este esfuerzo multisectorial, el Fondo de Cooperación para el Desarrollo Social (FONCODES) del Ministerio de Desarrollo e Inclusión Social (MIDIS) viene implementando desde el 2017 el programa “Mi Abrigo”, el cual tiene como finalidad mejorar las viviendas para asegurar una temperatura adecuada durante las heladas. El acondicionamiento térmico de las viviendas rurales sigue un modelo estándar de aplicación de técnicas de aislamiento y retención del calor en las paredes, pisos, ventanas y puertas. El presente estudio busca contribuir a este proceso, identificando oportunidades de mejora de los aspectos técnicos y logísticos en el acondicionamiento de viviendas, a fin de lograr una mayor eficiencia del programa. El estudio propone nuevos criterios y conceptos para responder mejor a la diversidad de realidades que se encuentran en los territorios altoandinos. Entre las soluciones propuestas se incluye el empleo de técnicas y materiales locales para reducir costos y tiempos, por ejemplo ichu, cabuya o totora como aislantes térmicos en paredes. También se considera la utilización de revoques de barro, en lugar de yeso y cemento, que tiene un mejor comportamiento térmico y mantiene la cualidad paisajística. Este estudio ofrece una serie de alternativas tecnológicas para cada componente de la edificación que se pueden combinar de manera modular, pudiendo combinar tecnologías modernas con técnicas ancestrales de construcción y aislamiento térmico. El mejoramiento de las condiciones térmicas de las viviendas rurales contribuye a su vez a mejorar la protección de la salud y la calidad de vida de las familias más vulnerables.
Unpacking the Childcare and Education Policy Response to the COVID-19 Pandemic: Insights from the Canadian Province of Quebec
Authors: Mathieu Sophie
Published: October 2021

Building from Blum and Dobrotić’s conceptual framework, this paper shows that the decisions to reopen childcare centres and schools in the Canadian province of Quebec in 2020 were influenced by four goals: (1) protecting public health, (2) promoting academic success / fostering early education, (3) addressing social inequalities, and (4) helping parents to reconcile employment and care activities. Although the first three objectives were considered in the sequence of reopening, the government quickly chose to prioritize work-family reconciliation above other objectives. Quebec’s tight sequence of reopening childcare centres and schools is not simply a consequence of evolving research showing lower risks associated with COVID-19 for young children, it also reflects the province’s cultural norms toward mothers’ employment and the high legitimacy of the state in subsidizing childcare.
Essence of Family-Pedagogical Cooperation at Modern school
Authors:   Saratov State University, Hutoryanskaya T. V.
Published: October 2021

In article results of the analysis of various treatments of concept «cooperation» with positions of pedagogical and psychological sciences are presented. The essence of family-pedagogical cooperation at modern school reveals.
Values and Motives of the Individual Factors as the Choice of Profession school Graduates
Authors:   Saratov State University, Gracheva O. G.
Published: October 2021

The article deals with the values and motives of the individual factors as professional self‑seniors, their place in the socialization and the results of research of values and motives of the profession school graduates.
Valuable Conflictness, Coping – strategy and temperament
Authors:   Saratov State University, Krasilnikov I. A.
Published: October 2021

In the article results of empirical research of connections between a valuable conflictness, coping‑strategy and properties of temperament are presented. Some connections with the sharp form of a valuable conflictness which we name semantic deadlock are certain also.
Personality, Creativity, self-realization
Authors:   Yaroslavl State University, Kozlov V. V.
Published: October 2021

This article is devoted to analysis of the categories of creativity, personality, psychology, self‑ actualization, ratios, real and demonstrative I man. This article describes the author’s understanding of creativity as a transpersonal phenomenon, self‑realization as go beyond their limitations.
Current trends in the training of Pre-school Education
Authors:   Volgograd State Social and Pedagogical University, Korepanova M. V.
Published: October 2021

Article explores the problems of training for pre‑school education in‑ novative development of economy, the increasing demands of society towards quality education based on an analysis of the problems hin‑ dering innovation in pre‑school education are priority areas for im‑ proving the existing system of teacher training. Identifies conditions that ensure the quality of training the student to professional activities. Stresses the significance of the fluidity of education based on the desire to learn and improve their skills.
Cardiovascular Risk Factors and COVID-19 Incidence: Result From a Population-Based Study
Authors: Sadeghipour Parham , Rafiee Farnaz , Baghizadeh Elahe , Barati Somayyeh , Maleki Majid , Mohebbi Bahram , Bakhshandeh Hooman
Published: October 2021

The article's abstract is not available.
The Changing Scenario of Mathematics Formative Assessment in the Era of Globalization
Authors: Ambrosio Joezel , Bautista Rhona Lyn , Cabillan Maria Linda , De Vera Nora , Unson John Carlo , Winnan Glory Ann Julien
Published: October 2021

Researches on formative assessment have mentioned its importance in the teaching and learning method. However, there are little to no known researches on formative assessment centered in Mathematics and higher education. This research intends to investigate the awareness and development of formative assessment in undergraduate Mathematics education in a top university in the Philippines, Saint Louis University, currently having more than 30,000 students. Specifically, this research determines the current scenario of formative assessment as it seeks to recognize the adaptation and usage of formative assessment, identify the challenges and opportunities that Mathematics educators face in formative assessment with regards to globalization, and describe the characteristics of the Mathematics educators based on their extent of use of 21st century formative assessment strategies and tools. Furthermore, this descriptive qualitative research attempts to identify the challenges needed to be overcome by the Mathematics sector to satisfy the globalized skills students needed to attain.
Vocabulary and Identification of Information: Difficulties and Challenges in Word Problems Solving
Authors: Unson John Carlo
Published: October 2021

Word problems solving continues to be a problem for both students and teachers alike. As researches in word problem solving along reading comprehension are continuously undertaken, the problem remains timely and relevant as only few have shed light into the difficulties and challenges in word problem solving brought about by vocabulary and identification of information. This research intends to identify the areas of difficulties and challenges experienced by students and teachers in the senior high department in a top university in the Philippines, the University of the Cordilleras, which has a wide array of quality programs in the said department. Results obtained in this research may be used not only by students and teachers but also by authors, parents, aspiring teachers, aspiring school owners, or anyone who aspires for their personal development in Mathematics.
Role of Private Sector in Developing Employment through Skill Development Programme: A Case Study of Odisha
Authors: Sahoo Chinmaya kumar
Published: October 2021

तत्कर्म यन्न बन्धाय सा विद्या या विमुक्तये ।
                                          आयासायापरं कर्म विद्यान्या शिल्पनैपुणम् ॥
The above mentioned slokas are derived from VISHNU PURANA a great mythological and is one of the eighteen Mahapuranas, a genre of ancient and medieval texts of Hinduism. It means Action is that, which does not promote attachment; that is knowledge which liberates. All other action is mere effort/hardship; all other knowledge is merely another skill/craftsmanship. Present day skill refers to knowledge which can be applied in executing/solving a particular task. This also provides a person to earn his day to day livelihoods’. The skill development programme initiated at different level such as local bodies, corporatehouses, state government, central government and other authorities has the objective to empower the unemployed youth to increase their employability or engagement opportunities, so that they can be useful in contributing their individual income as well as in the national income. The corporate houses have launched massive skill development programmes through their CSR spending. They ensure to train and develop skill at the ground level and facilitate in the employment/engagement after successful completion of training. The present research paper is undertaken to study how the corporate houses impacting skill development programme in the society through their CSR programmes.
The Effect of Supply Chain Practices on Perceived Organizational Performance
Authors: Sabry Mohamed Ahmed Ibrahim , Elwany Hamdy , El-Nakib Islam , Ragheb Mohamed
Published: October 2021

This research focuses on to identify the relationship between supply chain management practices (supplier relationship, supply chain complexity, information sharing, information quality, logistics and strategic location) with perceived organization performance through the mediating role of supply chain performance (supply chain integration, supply chain flexibility and supplier performance) in oil and gas companies in Egypt. Then the relationship between the three variables will be tested and examined. Literature and prior studies related to this field are reviewed to construct the research hypotheses, which state that there is a significant relationship between Supply Chain Management and Supply Chain Performance, there is a significant relationship between Supply Chain Performance and Perceived Organizational Performance, and there is a significant relationship between Supply Chain Management and Perceived Organizational Performance. These hypotheses will be tested throughout the research study. Primary data is collected from supply chain employees in 61 companies of the petroleum agency in Egypt using a quantitative approach (Questionnaire). The data collected is analyzed and then the results of the analysis and findings are demonstrated by the end of the research with some recommendations to Egyptian SMEs to enhance their Perceived Organizational Performance.
The influence of entrepreneurial capital on social transformation by social enterprises in Kiambu County, Kenya
Authors: Francis K. Njenga , Daniel M. Kitonga , Francis M. Gatumo
Published: October 2021

Several studies have found entrepreneurial capital or finance to be significant in growth and performance of enterprises. This development has led the researchers in the present study to investigate the role of entrepreneurial capital in social transformation by social enterprises in Kiambu County, Kenya. This journal examines the influence of entrepreneurial capital on social transformation. The context of the study was Kiambu County, Kenya. Social entrepreneurship theory, market failure theory, empowerment theory, planned behavior theory and cultural dimension’s theory guided the study. The study used a descriptive survey design guided by a mixed methods research approach. The sample size was 322 social enterprises drawn from a target population of 1944 social enterprises distributed all from Kiambu County. Data was collected using survey questionnaires and interview guide instruments.  Simple random sampling technique was used to get the proportionate sample for each strata.  Data was descriptively and inferentially presented and analyzed. The findings shows R-value of .614, R2 value of .377, adjusted R2-value of .375; F-statistics value is 1977.052 greater than critical value of 3.85 and p- value was 0.000. The study concludes that entrepreneurial capital has a statistically significant and positive effect on social transformation by social enterprises.
Adsorption Behavior of Pb, Cd, Ca, Al, Zn And Co Metal Ions on Cation Exchange Resin Dowex 50 Wx8 (Nh4+ Form) From Aqueous Acetone-Ammonium Propionate Media
Authors: Kamble S Rajan
Published: October 2021

There has a wide interest in stability of different types of ion exchange resins against ionizing radiations. The irradiation damage and stability of polystyrendigni benzene and phenolformaldehide sulphonic acid ion exchange resins was investigated by determination of the radiolytic gases. The gas analysis showed a very good linear dose dependence of the evolved hydrogen and carbon monoxide. The linearity of carbon dioxide was good for Dowex 50 WX 10 but less pronounce for zeo-carb 215. Sulphur dioxide was at least partially produced by direct action and was consumed by secondary reaction during irradiation. Kuzin  et al [1] analysed radiolytic gases evolved from a carboxylic acid exchange resin. Wiely et al [2] investigated gamma radiation induce degradation of sulphonetic styrle resin cross link with 4 and 8 % m / p dinyl benzene isomer or mixtures thereof including commercial divenyle benzene have been shown loss in capacity 5-12. 8% at the radiation intensities of 290 R/hr and total dose 0.91 – 1.0 x 10-8 rad in presence of water.
A semiotic comparison of mass media representations of the swine flu and Covid-19 pandemics: Observing Narcissus Narcosis
Authors: Olteanu Alin , Rabitz Florian , Nalivaikė Augustė
Published: October 2021

This paper compares the coverage of the H1N1 and Covid-19 pandemics in ten prominent US daily newspapers. We selected articles that reference disease-specific keywords, published in the period between the declaration of a Public Health Emergency of International Concern by the World Health Organization and the first peak in laboratory- confirmed cases in the USA (20550 articles on Covid-19 and 1705 articles on H1N1). We analyzed the dataset via topic models and semantic networks, which, in a semiotic approach, are understood as iconic models. As the Covid-19 virus produced the first global pandemic in the age of social media, this comparative analysis illustrates how the news media changed the mediasphere in general. During the H1N1 pandemic (2009-2010), newly emerging social media were not mainstream, having a limited impact compared to 2020 at the outbreak of Covid-19. By 2020, social media have definingly changed the mediasphere. Given their affordance for the virulent transmission of media products, the rise of social media stirred the relativization of knowledge and mistrust towards traditional authority and legacy media. Paradoxically, this both democratizes public debate and opens opportunities for misinformation. In this context, the Covid-19 pandemic has been accompanied by a global infodemic, with adverse impact on global health. While the two pandemics are very different, comparing media representations in their early stages, when the viral spread was unpredictable, offers an insight into how the emergence of social media impacted traditional newspapers’ approach to events of global concern. The analysis reveals that ideological commitments are expressed through the same correlation of topics in both corpora but that, overall, the discourses have different structures. We argue that the remarkable stability of ideological discourses displays what McLuhan termed Narcissus narcosis, namely the numbness experienced socially during media changes.
ADLA(NDIRMALA)RIMIZ
Authors: ULUCAN Mehmet
Published: October 2021

Varlık(lar) ve varlığımız adlarla anlaşılabilir. Farkındalığın tezahürü ve karşılığı ilk olarak adlarda ve adlarla ortaya çıkar. Adlarla ilgili en önemli husus, anlam(ları) olmasına rağmen diğer hususlar da son derece önemlidir. Adlar ve adlandırmaların günlük dilde, resmî ve yazı dilinde önemli görevleri vardır. Bütün dünyada yeni icat ve üretimlerde ad ve adlandırmalar çok önemlidir. Bu icat, üretim ve geliş(tir)meler sosyal alanlarla doğrudan, diğer alanlarla dolaylı olarak ilgili ve ilişkili olduğu bilinmektedir. Özellikle ilk ad(landırma)ların ne denli önemli olduğu gayet açıktır. Bunda din, ırk, tarih, kültür ve mitoloji önem arz eder. Adlar, bütün dillerde en çok ortak kullanılan unsurlardır. Bu yüzden dünyadaki dil bilimi çalışmalarında; adbilim çalışmaları ayrı bir alan olarak ortaya çıkmıştır. Ad(landırma)larda daha çok özel adlar öne çıkmaktadır. Özel adlar, çoğunlukla millî olmakla beraber evrensel olanlar da oldukça fazladır. Bu adlarda daha çok az bulunur ve bilinir olmasına dikkat edilmektedir.

Makalemizde daha çok -son zamanlarda- tercih edilen özel adlarda nelerin etkili olduğu üzerinde durulmuştur. Bu hususta bazı çekinceler, eksiklikler, yanlışlıklar, böbürlenmeler ve bencillikler görülebilmektedir.
Metadados de preservação digital e os registros digitais arquivísticos
Authors: Silva Pedro Felipy Cunha da , Araújo Wagner Junqueira de , Siebra Sandra de Albuquerque
Published: October 2021

A intensa utilização de plataformas eletrônicas, especialmente no contexto da pandemia do Covid-19, provocou um aumento significativo dos registros digitais, que documentam os mais variados tipos de atividades pessoais e profissionais. Isto evidenciou a necessidade de descrever e contextualizar estes registros, a fim de contribuir para sua preservação e acesso a longo prazo. Assim, este artigo objetiva fazer uma reflexão acerca das condições que tornam um registro digital, arquivístico e a importância de se considerar os metadados destes registros para a sua preservação. As discussões foram desenvolvidas com base em uma revisão sistemática de literatura, fazendo uso do método PRISMA. Constatou-se que, a partir do instante que o metadado passa a fazer parte do registro digital arquivístico, os cuidados para a gestão desses metadados passam a ser tão importantes quanto os cuidados para a gestão do documento ou registro, isoladamente. Já que é impossível realizar a preservação de longo prazo destes materiais sem o efetivo gerenciamento dos metadados que o compõem. Conclui-se que é premente, por parte dos Arquivistas, ampliar a compreensão dos registros digitais arquivísticos como um constructo teórico com desafios conceituais e pragmáticos diferentes, mas não excludentes, daqueles existentes no documento arquivístico digital
Buku Ajar Analisa Kelayakan Usaha
Authors: Sulistiyowati Wiwik S
Published: October 2021

Dengan mengucapkan puji syukur Allhamdullillah, atas berkat rahmat Allah SWT, kami dapat menyelesaikan buku ajar dengan judul “Analisa Kelayakan Usaha”. Kami selaku penyusun mengucapkan terima kasih kepada semua pihak yang telah membantu kami selama proses pelaksanaan penyusunan sampai dengan terselesainya buku ajar ini. Kami menyadari, dalam buku ajar yang kami susun masih banyak kekurangan, sehingga kami berharap pembaca dan pengguna dapat memberikan masukkan/ kritik yang sifatnya membangun. Semoga apa yang kami hasilkan ini dapat memberikan manfaat bagi pembaca dan mahasiswa.
Review of Friction Reducers Performance Applied to the Marcellus Shale Region
Authors: McIntyre Morgan , Kelly Cayman , Kudrashou Viacheslau , Kazemi Mohammad
Published: October 2021

Polyacrylamide-based friction reducers (FRs) are widely used in hydraulic fracturing to reduce friction created within fluid as it flows through tubulars or other restrictions. These polymers generally add viscosity to the fluid to reduce the turbulence induced as fluid flows. Type and amount of total dissolved solids (TDS) in source water have significant impact on performance of FRs. This study investigates these effects and evaluates various types of FRs applied to the Marcellus Shale region.

It was found that increase in salinity often causes significant performance degradation (Mantell et al., 2011). This is especially critical for application of FRs in Marcellus shale that is known for challenging brine contents. This effect is more pronounced for some divalent cations than for monovalent ones. Addition of surfactant systems can improve FR performance by extending the salt tolerance. Overall, it can be concluded that FR optimization for given water content and proppant can be done by adjusting FR type and/or concentration. For special applications, when higher proppant loading is desired, applying Viscosifying Friction Reducers (VFRs) and High Viscosity Friction Reducers (HVFRs) are proven to be preferable. It was demonstrated that slickwater viscosity tend to increase exponentially with VFR concentration increase. At the same time VFRs should be breakable to ensure high regained proppant conductivity and minimization of formation damage. Such result would further justify the transition from traditional gelled fluids to FR-based viscous slickwater.

This comprehensive review explores the application of various types of FRs for Marcellus shale region. It defines the critical TDS levels, and types of cations that require changes in FR type or dosage. This data can benefit operators in (1) optimizing performance of the FR-based completion fluid; (2) avoiding formation damage associated with usage of unjustified additives; and (3) comparing/qualifying FRs based on their optimal range of application and economical dosage.
Ether Anesthetics Obstructs Touch-Induced Trigger Hair Calcium-Electrical Signals Preventing Excitation of The Venus Flytrap
Authors: Scherzer Sönke , Huang Shouguang , Iosip Anda , Fuchs Ines , Yokawa Ken , AL-Rasheid Khaled A. S. , Heckmann Manfred , Hedrich Rainer
Published: October 2021

Plants do not have neurons. Instead they operate transmembrane ion channels and can be electrically excited by physical and chemical clues. The Venus flytrap with its distinctive hapto-electric signaling is a prime example. When an insect collides with the trigger hairs emerging from the inner surface of the trap, the mechanical stimulus in the mechanosensory organ is translated into a calcium signal and an action potential (AP). Here we asked how a Ca 2+ wave and AP are initiated in the trigger hair and how these are fed into the systemic trap calcium-electric network. When the Dionaea muscipula trigger hair matures and develops hapto-electric excitability, the mechanosensitive anion channel DmMSL10 and voltage dependent SKOR type Shaker K + channel are expressed in the shear stress-sensitive podium, which interfaces with the flytrap’s prey capture and processing networks. In the excitable state, touch stimulation of the trigger hair first evokes a rise in the podium Ca 2+ , then the calcium signal together with an action potential, travel over the entire trap surface. Seeking the mechanisms that mediate touch-induced Ca 2+ transients in the mature trigger hairs, we show that OSCA1.7 and GLR3.6 type Ca 2+ channels and ACA2/10 Ca 2+ pumps are specifically expressed in the podium. In addition, we found that direct glutamate application to the trap evoked a propagating Ca 2+ and electrical event. Given that anesthetics affect K + channels and glutamate receptors in animal systems, we exposed flytraps to ether. An ether atmosphere suppressed the propagation of touch and glutamate-induced Ca 2+ and AP long-distance signaling, a response that was completely recovered when ether was replaced by fresh air. In line with ether targeting a calcium channel, so triggering a Ca 2+ activated anion channel, the AP amplitude declined before the electrical signal ceased completely. Ether in the mechanosensory organ neither prevented the touch induction of a calcium signal nor its post stimulus decay. This finding indicates that ether prevents the touch activated GLR3.6-expressing base of the trigger hair so exciting the capture organ.
Incidence And Risk Factors of Hypertension Therapy In Australian Cancer Patients Treated With Vascular Signalling Pathway Inhibitors
Authors: Hong Soojung , Daniels Benjamin , Leeuwen Marina T. , Pearson Sallie-Anne , Vajdic Claire M.
Published: October 2021

Background Clinical trials report systemic hypertension is an adverse effect of vascular signalling pathway inhibitor (VSPi) use. There are limited data from routine clinical practice. We aimed to estimate the real-world incidence and risk factors of new-onset and aggravated hypertension for cancer patients dispensed VSPi in whole-of-population Australian setting.Methods We used dispensing records for a 10% random sample of Australians to identify treatment with subsidised VSPi from 2013-2018. We further identified dispensings of oral antihypertensive medicines 6 months before and during VSPi therapy. We defined (i) new-onset hypertension in people first dispensed antihypertensives after VSPi and (ii) aggravated hypertension in people with prior antihypertensive use dispensed an additional, or higher strength, antihypertensive after VSPi. We applied the Fine-Gray cumulative incidence function and Cox proportional hazard regression.Results 1,802 patients were dispensed at least one VSPi. The mean age of the cohort was 65 years and 57% were male. The incidence of new-onset treated hypertension was 24.3% (95%CI: 21.2-27.8); age ³60 years (HR 1.74; 95%CI: 1.32-2.31) and treatment with oral tyrosine kinase inhibitors compared to bevacizumab (HR 1.96; 95%CI: 1.16-3.31) were risk factors. The incidence of aggravated hypertension was 25.2% (95%CI: 22.0-28.7) and risk was elevated for patients with renal cancer (HR 2.84; 95%CI: 1.49-5.41) and cancers other than colorectal (HR 1.85; 95%CI: 1.12-3.03).Conclusions Our real-world estimates of incident hypertension appear comparable to those observed in clinical trials (21.6-23.6%). Our population-based study provides some insight into the burden of hypertension in patients commencing VSPi in routine practice.
Marketing Analysis: Antiemetic Drugs on the Pharmaceutical Market of Uzbekistan
Authors: qizi Samedinova Dilnoza Nuriddin , Mannanovna Yunusova Kholida
Published: October 2021

In this study, we analysed, with the help of the “State Register of Medicines, Medical Devices and Medical Equipment Permitted for Use in Medical Practice of the Republic of Uzbekistan”, the number, dosage forms and cost of registered antiemetic drugs in 2016-2020 based on the DRUG AUDIT program, which offers a database of information from 2016 to 2020.
Docking of Velpatasvir to the SARS-CoV-2 Viral Spike Protein-Human ACE2 Complex: repurposing for COVID-19
Authors: Zia Asad , Akhtar Sohail , Khan Mubarak Ali
Published: October 2021

The SARS-CoV-2 outbreak has challenged the world health community and is still out of control. Since there is no clinical drug available for the corona virus therefore the most important and the fastest way of medicines development is to find potential molecules from the marketed drugs. Herein, bioinformatics analysis on the spike protein (S) of CoV and human angiotensin receptor 2 (ACE-2) with already approved anti-HCV approved drug velpatasvir have been reported. We conducted molecular docking to determine the mode of interaction of velpatasvir and RNA dependent RNA polymerase enzyme as well as inhibition of attachment of S-protein with human host receptor ACE-2. We found that, velpatasvir not only binds tightly with S-protein-ACE2 interface but also with 2019-Cov RdRp, can alter the structure and function of the said proteins and hence will results in the eradication of viral infection. The findings of this study further support the idea of drug repurposing and will help to classify the most successful drugs against COVID-19.
Ideal free flows of optimal foragers: Vertical migrations in the ocean
Authors: Thygesen Uffe Høgsbro , Mazuryn Maksim
Published: October 2021

We consider the collective motion of animals in time-varying environments, using as a case diel vertical migration in the ocean. The animals are distributed in space such that each animal moves optimally, seeking regions which offer high growth rates and low mortalities, subject to costs on excessive movements as well as being in regions with high densities of conspecifics. The model applies to repeated scenarios such as diel or seasonal patterns, where the animals are aware of both current and future environmental conditions. We show that this problem can be viewed as a differential game of mean field type, and that the evolutionary stable solution, i.e. the Nash equilibrium, is characterized by partial differential equations, which govern the distributions and migration velocities of animals. These equations have similarities to equations that appear in the fluid dynamics, specifically the Euler equations for compressible inviscid fluids. If the environment is constant, the ideal free distribution emerges as an equilibrium. We illustrate the theory with a numerical example of vertical animal movements in the ocean, where animals are attracted to nutrient-rich surface waters while repulsed from light during daytime due to the presence of visual predators, aiming to reduce both proximity to conspecifics and swimming efforts. For this case, we show that optimal movements are diel vertical migrations in qualitative agreement with observations.
Biomechanical behaviour and hyperelastic model parameters identification of sheep omasum
Authors: Lebea Lebohang , Ngwangwa Harry , Pandelani Thanyani , Nemavhola Fulufhelo
Published: October 2021

The function of the omasum is incompletely understood; however, the omasum plays an important role in the transport of appropriately sized feed particles from the reticulorumen to the abomasum, oesophageal groove closure, fermentation of ingesta, and absorption of water, volatile fatty acids, and minerals. The aim of this study is to evaluate the suitable hyperelastic anisotropic model based on biomechanical properties of sheep omasum. The results show that all five (5) hyperelastic models may be suitable for the evaluation of sheep omasum. The average coefficient of determination (R2) of Fung, Polynomial (Anisotropic), Holzapfel (2000), Holzapfel (2005) and Four-Fiber-Family hyperelastic models were found to be 0.79 ± 0.19, 0.95 ± 0.05, 0.92 ± 0.07, 0.93 ± 0.05 and 0.94 ± 0.03, respectively. Also, it was found that the best hyperelastic model for fitting uniaxial data of the sheep omasum was Polynomial (Anisotropic) with EI of 100.0 followed by the Four-Fiber-Family model with EI of 96.18.
Comparative Effectiveness of Second-Line Biological Therapies for Ulcerative Colitis and Crohn’s Disease in Patients With Prior Failure of Anti-Tumour Necrosis Factor Treatment
Authors: Hyun Hye Kyung , Yu Jongwook , Kang Eun Ae , Park Jihye , Park Soo Jung , Park Jae Jun , Kim Tae Il , Kim Won Ho , Cheon Jae Hee
Published: October 2021

Background
Therapeutic options for inflammatory bowel disease (IBD) have increased since the introduction of tumour necrosis factor (TNF) inhibitors a few decades ago. However, direct comparisons of the effectiveness of second-line biological agents in patients with ulcerative colitis (UC) and Crohn’s disease (CD) are lacking.
Methods
Patients with UC or CD who experienced anti-TNF treatment failure and subsequently used vedolizumab, ustekinumab, or tofacitinib as a second-line drug were retrospectively recruited. The primary outcomes were the clinical remission rate at week 16 and the cumulative relapse rate 48 weeks after receiving induction therapy.
Results
A total of 94 patients with UC or CD experienced anti-TNF treatment failure and received vedolizumab (UC: 37; CD: 28), ustekinumab (CD: 16), or tofacitinib (UC: 13). The clinical remission rates were not significantly different between the vedolizumab and tofacitinib groups in UC patients (56.8% vs. 46.2%, p = 0.509). In CD patients, the clinical remission rates were not significantly different between the vedolizumab and ustekinumab groups (53.6% vs. 50.0%, p = 0.820). Moreover, the cumulative rates of clinical relapse were not significantly different between the vedolizumab and tofacitinib groups in UC patients and between the vedolizumab and ustekinumab groups in CD patients (p = 0.396 and p = 0.692, respectively). Safety profiles were also similar among the treatment groups in both UC and CD patients.
Conclusions
After prior anti-TNF therapy failure, vedolizumab and tofacitinib in UC patients and vedolizumab and ustekinumab in CD patients showed similarities in terms of the efficacy in inducing and maintaining a clinical response.