bluuebunny/crossref_metadata_2025 huggingface dataset:
Hypoxia-Inducible Factor-1 Alpha Stabilization in Human Macrophages during Leishmania major Infection Is Impaired by Parasite Virulence
Authors: Ben-Cheikh Ali , Bali Aymen , Guerfali Fatma Z , Atr Chiraz , Attia Hanène , Laouini Dhafer
Published: October 2022

Hypoxia-inducible factor-1 alpha (HIF-1α) is one of the master regulators of immune and metabolic cellular functions. HIF-1α, a transcriptional factor whose activity is closely related to oxygen levels, is a target for understanding infectious disease control. Several studies have demonstrated that HIF-1α plays an important role during the infectious process, while its role in relation to parasite virulence has not been addressed. In this work, we studied the expression levels of HIF-1α and related angiogenic vascular endothelial growth factor A (VEGF-A) in human macrophages infected with promastigotes of hypo- or hyper-virulent Leishmania major human isolates. L. major parasites readily subverted host macrophage functions for their survival and induced local oxygen consumption at the site of infection. In contrast to hypo-virulent parasites that induce high HIF-1α expression levels, hyper-virulent L. major reduced HIF-1α expression in macrophages under normoxic or hypoxic conditions, and consequently impeded the expression of VEGF-A mRNA. HIF-1α may play a key role during control of disease chronicity, severity, or outcome.
Cerebral Paragonimiasis Presenting with Dementia
Authors: Moon Seok Woo , Kim Taeho
Published: October 2022

We report a case of an 80-year-old Korean man with chronic cerebral paragonimiasis who presented with progressive memory impairment. He suffered from pulmonary paragonimiasis 60 years ago and has been experiencing epilepsy since the age of 45. He began experiencing memory and cognitive deterioration 3 years ago. He visited the neuropsychiatric department of our hospital to check his symptoms and health from a year ago. Contrast-enhanced brain magnetic resonance imaging study revealed calcifications and cystic lesions encompassing the right temporo-occipital region. Encephalomalatic changes were also observed in the right occipital and temporal areas. The anti-Paragonimus specific IgG antibodies in his serum showed a strong positive response. The neuropsychological test results showed a Global Deterioration Scale of 4 and a Clinical Dementia Rating Scale of 1. The chronic cerebral paragonimiasis lesions in the patient’s right temporo-occipital region might induce the dementic change.
Excretory-Secretory Products of Trichomonas vaginalis Cause Apoptosis in Mouse Sperm in Vitro
Authors: Keum Jihyun , Roh Jaesook , Ryu Jae-Sook , Ryu Ki-Young
Published: October 2022

Excretory-secretory products (ESP) of T. vaginalis have been shown to inhibit sperm motility, viability, and functional integrity, leading to a decreased fertilization rate in vitro. This study investigated whether T. vaginalis induce apoptosis and ultrastructural changes of sperm using flow cytometry and electron microscopy. Incubation of sperm with T. vaginalis ESP increased phosphatidylserine externalization and DNA fragmentation, and decreased mitochondrial membrane potential. Transmission electron microscopy of sperm incubated with ESP revealed abnormal features such as distorted heads, broken necks, and acrosomes exocytosis. This is the first report that demonstrates a direct impact of T. vaginalis ESP on sperm apoptosis and architecture in vitro.
Development of web-based general biology content on the GEN-BIO platform
Authors: Prayitno Trio Ageng , Hidayati Nuril
Published: October 2022

The development of valid online learning media is currently very necessary in supporting the biology learning process. A high percentage of students had misconceptions about general biology material in biology education (75%), a high percentage of student responded that are difficult to get valid general biology material on the internet (40.2%), and a high percentage of student responded so that lecturers make valid general biology material (94,1%), and the high percentage of student responses so that general biology material can be in the form of a web app (70.6%). The research objective is to produce a web app-based general biology content form on the GEN-BIO platform that meets the valid criteria. The method used in this research is R&D with the Thiagarajan development model consisting of define, design, and develop. While the disseminate will be carried out in the next research using a quasi-experimental method. The research instrument used was a needs analysis sheet in the form of a G-form given to 100 respondents, a Semester Lecture Plan (SLP) analysis sheet, a material expert validation sheet given to one lecturer, a media expert validation sheet given to one expert, a practitioner validation sheet given to give to one lecturer, and the readability test sheet given to 43 students. All instruments used in this study have been declared valid by the evaluator. Research data is a score of validity in the form of quantitative data and complementary information in the form of qualitative data. The data analysis technique used is descriptive quantitative. The results showed that it has been produced general biology content based on the web app on the GEN-BIO platform has been declared valid from material elements (98.06%), media elements (94.47%), practitioners (95.33%) and student readability (34, 02% strongly agree, 57.93% agree). The research concludes that the general biology content based on the web app on the GEN-BIO platform is suitable for offline and online learning in general biology courses in Higher Education, especially in the Department of Biology Education and the Department of Biology.
Partisipasi Orang Kristen di dalam Pemilihan Umum
Authors: Dominggus Markus
Published: October 2022

Ruang besar yang disediakan oleh undang-undang mengenai pemilu bagi partisipasi rakyat dimanfaatkan oleh orang-orang Kristen di Malang Raya pada tahun pemilu 2014 dan 2019 melalui sebuah jaringan kerja sama antarindividu Kristen yang disebut Marindo. Penelitian ini bermaksud menggambarkan dinamika keterlibatan tersebut dalam atmosfer politik Indonesia yang khas. Tesis yang mau diangkat ialah bahwa berangkat dari kondisi-kondisi tertentu yang dihadapinya di wilayah ini, orang-orang Kristen menempuh suatu strategi yang memberinya keleluasaan gerak dalam menggalang kekuatan elektoralnya. Kontribusi khusus penelitian ini kepada temuan-temuan terdahulu ialah pada penggunaan strategi nonkelembagaan dengan segala problematikanya di tengah iklim demokrasi elektoral Indonesia. Di tataran yang lebih teoretis, ia melengkapi temuan-temuan lain tentang strategi-strategi kelompok minoritas untuk mengambil bagian dalam proses demokrasi. Penelitian ini menggunakan pendekatan kualitatif dengan metode studi kasus dan lensa interpretatif teori-teori tentang keterlibatan kelompok minoritas dalam proses demokrasi.
STUDI TENTANG KESULITAN MEMBACA PERMULAAN SISWA SEKOLAH DASAR
Authors: Hanisah Saidah
Published: October 2022

Tujuan dari penelitian ini adalah untuk mendeskripsikan kesulitan membaca permulaan yang dialami siswa dan faktor-faktor dari kesulitan membaca permulaan. Jenis penelitian ini adalah penelitian kualitatif dengan metode studi kasus. Sumber data dalam penelitian ini adalah siswa, guru, dan orangtua dengan subjek penelitian adalah seorang siswa kelas III Sekolah Dasar. Hasil dari penelitian ini adalah kesulitan membaca permulaan yang dialami seperti tidak lancar dalam membaca, banyak kesalahan dalam membaca, sulit membedakan huruf yang hampir mirip, dan kesalahan dalam pelafalan kata atau simbol bunyi. Faktor-faktornya adalah faktor internal yaitu minat dan kemampuan kognitif siswa serta faktor eksternal yaitu orangtua dan peralihan sistem pembelajaran era Covid-19
PENERAPAN MODEL PEMBELAJARAN AQIDAH AKHLAK BERBASIS PROJECT BASED LEARNING DI MADRASAH ALIYAH NURUL ISLAM NGESREP BOYOLALI
Authors: Firda Ainul Luthfia Al , Pamungkas Nikmatul Choiroh
Published: October 2022

Rendahnya minat anak didik khususnya dalam belajar aqidah akhlak di MA Nurul Islam  Boyolali menjadi latar belakang dari penelitian ini. Rendahnya minat tersebut ditandai dengan monotonnya metode pembelajaran aqidah akhlak dengan metode verbalistik. Hal ini menimbulkan kejenuhan siswa dalam belajar. Beberapa guru juga terbentur dengan keterbatasan dalam penggunaan tekhnologi. Oleh sebab itu pengembangan metode belajar dirubah dengan gaya pembelajaran project based learning (PjBL). Tujuan dari penelitian ini untuk melihat efektifitas penerapan metode pembelajaran aqidah akhlak berbasis project based learning di MA Nurul Islam Boyolali. Metode penelitian menggunakan metode tindakan kelas dengan tahap perencanaan dan praktik tindakan kelas. Hasil penelitian menyatakan sebagian besar anak didik mulai tertarik untuk belajar aqidah akhlak, mulai memperdalam ilmu agama, aktif dan kooperatif dalam kerja kelompok, inovatif, kritis mampu memecahkan masalah dan manajemen waktu, serta ketertarikan pada suatu mata pelajaran cinderung meningkat.Kata Kunci : Metode Pembelajaran, Project Based Learning, Pendidikan
PENINGKATAN PENGUASAAN KONSEP SISWA PADA MATERI GERAK LURUS MELALUI PEMBELAJARAN MODELING INSTRUCTION
Authors: Hidayah Nurul , Yunitasari Indah , Aini Meliyana
Published: October 2022

Topik kinematika dalam ilmu fisika masih menjadi salah satu materi yang  terdapat kesulitan bagi siswa dalam mempelajarinya. Kesulitan yang dialami siswa mengakibatkan siswa mengalami kesalahpahaman konsep dalam menguasai materi kinematika seperti konsep posisi, kecepatan, dan percepatan.  Modeling Instruction merupakan salah satu model pembelajaran yang melibatkan siswa aktif dalam pembelajaran. Tujuan penelitian ini untuk meningkatkan penguasaan konsep siswa pada materi gerak lurus melalui Modeling Instruction. Pada penelitian ini digunakan metode penelitian kuantitatif. Data penelitian diperoleh dari hasil pretest dan posttest. Selanjutnya ditentukan uji normalitas yang selanjutnya untuk mengetahui peningkatan penguasaan konsep siswa dilakukan uji beda dengan N-gain.  Hasil uji formalitas diperoleh hasil -1 sampai 1 sehingga data dikatakan terdistribusi normal.  Selanjutnya dilakukan uji beda dengan N-gain dengan hasil 0,30 artinya ada peniingkatan penguasaan konsep siswa dengan kategori medium bawah
ANALISIS KEBUTUHAN PENGEMBANGAN MULTIMEDIA INTERAKTIF BERBASIS FLIPBOOK DALAM PELATIHAN JARAK JAUH PERPAJAKAN UNTUK PEGAWAI PUSAT PEMBINAAN PROFESI KEUANGAN (PPPK)
Authors: Arifiani Dika
Published: October 2022

Media pembelajaran yang tepat akan berdampak dalam mendorong proses pembelajaran. Oleh karena itu, media pembelajaran yang digunakan harus selaras dengan tujuan pembelajaran. Penelitian ini menggali informasi mengenai pemanfaatan media pembelajaran, data kesulitan belajar, materi yang menjadi kesulitan belajar, serta mengenai pemanfaatan dan kesesuaian media flipbook dalam mengatasi kesulitan belajar peserta Pelatihan Jarak Jauh Perpajakan Untuk Pegawai Pusat Pembinaan Profesi Keuangan (PPPK). Hasil penelitian menyatakan bahwa media pembelajaran telah diamanfaatkan baik oleh peserta maupun pengajar, peserta mengalami kesulitan belajar terutama untuk mata pelajaran Pajak Penghasilan, untuk mengatasi kesulitan tersebut pengajar menambah/ mengubah media pembelajaran, serta media flipbook sesuai untuk mengatasi kesulitan belajar peserta.
PENGEMBANGAN KOMIK MATERI SISTEM PENCERNAAN MANUSIA PADA SISWA KELAS V SEKOLAH DASAR
Authors: Hayati Tika , Hermita Neni
Published: October 2022

Penelitian ini bertujuan Menghasilkan suatu komik materi sistem pencernaanuntuk siswa kelas V SD dan Mengetahui kelayakan komik materi sistem pencernaan untuk siswa kelas V SD. Penelitian ini menggunakan metode Research and Development (R&D) atau penelitian dan pengembangan dengan menggunakan model Borg and Gall (2003). Teknik pengumpulan data yang digunakan yaitu wawancara, angket dan tes tertulis. Kelayakan komik sebagai media pembelajaran IPA diperoleh dari hasil validasi, uji coba produk dan tes tertulis. Validasi dilakukan oleh ahli desain, ahli bahasa, ahli materi, dan praktisi. Uji coba produk yang dilakukan terbatas yaitu hanya 10 orang siswa. Tes tertulis yang digunakan berupa soal objektif untuk mengetahui pengetahuan dan pemahaman siswa terhadap komik IPA. Hasil penelitian menunjukkan bahwa media komik mendapat skor persentase pada aspek materi sebesar 91.07%, aspek desain komik sebesar 97.50%, aspek kesederhanaan sebesar 97.50%, aspek keterpaduan sebesar 96.88%, aspek penekanan sebesar 93.75%, dan aspek keseimbangan sebesar 100%. Sehingga rata-rata hasil validasi dari semua para ahli adalah sebesar 95.90% dengan kategori “Sangat Valid. Uji coba produk untuk mengetahui respon siswa terhadap komik memperoleh secara keseluruhan mendapat skor persentase sebesar 98,61%. Hasil penelitian tersebut dalam kategori “Sangat Baik”
Penggunaan Media Diorama Untuk Meningkatkan Hasil Belajar Pada PEmbelajaran IPS Kelas IV Sekolah Dasar
Authors: Safitri Devi , Munjiatun Munjiatun
Published: October 2022

Penelitian ini bertujuan untuk mengetahui penggunaan media diorama terhadap hasil belajar IPS tema daerah tempat tinggalku pada siswa kelas IV SD Negeri 193 Pekanbaru. Penelitian ini merupakan penelitian Quasi Experimental Type One Group Pretest-Postest Design yaitu penelitian eksperimen yang dilakukan pada satu kelompok saja yang dipilih secara acak. Instrumen yang digunakan dalam penelitian ini berupa tes. Hasil penelitian ini menunjukkan ada peningkatan penggunaan diorama media terhadap hasil belajar IPS tema daerah tempat tinggalku materi kegiatan ekonomi dan jenis-jenis pekerjaan yang menghasilkan barang dan jasa pada siswa kelas IV SD Negeri 193 Pekanbaru dengan penggunaan media diorama.Hal tersebut dapat dibuktikan dengan hasil perhitungan menunjukkan bahwa nilai rata-rata post test lebih besar dari rata-rata pre test. Rata-rata post test sebesar 85,3 yang berada pada kategori sangat baik dan rata-rata pre test sebesar 63,3 yang berada pada kategori cukup. Hasil perhitungan N-Gain menunjukkan bahwa nilai rata-rata kelas eksperimen 64,74 termasuk dalam kategori cukup efektif.
Cutaneous Mucormycosis Co-infection in a Patient with COVID-19
Authors: Rahgoshai Raham , Goldberg Peter , Rahgoshai Rayhaneh , Zain Shadi
Published: October 2022

Mucormycosis is a life-threatening fungal infection usually seen in patients who are immunocompromised; however, to date, it has been rarely described in patients with COVID-19, although more recently, reports from India have described an increased incidence of these infections. This report describes a patient with COVID-19 who developed a fatal dermatologic mucormycosis infection. The patient, whose history included therapy for diffuse large B-cell lymphoma, had an incidental positive screening test for COVID-19 in February 2021 after exposure to a family member who had tested positive. They then presented to the emergency room a few weeks later exhibiting progressive dyspnoea and fever. A CT scan of the chest revealed ground glass opacities. They were intubated approximately 2 weeks later and their course was complicated by renal failure, for which continuous renal replacement therapy was started, and by refractory hypoxaemic and hypercapnic respiratory failure in which they were placed on venovenous extracorporeal membrane oxygenation. During their course in the intensive care unit (ICU), they developed a right thigh haematoma, thought to be related to the previous insertion of a femoral arterial pressure monitoring catheter. Several days before the patient’s death, the wound noted to be covered by a brown-black eschar was cultured on April 30 and returned positive for Rhizopus oryzae and Staphylococcus epidermidis on May 5. The patient was immediately started on liposomal amphotericin and posaconazole and taken urgently taken to the operating room for a radical debridement. Unfortunately, their post-operative course was characterised by fulminant haemodynamic collapse and multiple system organ failure, from which the patient died.
A History of Disinterest: The Death Penalty and the Right to Interest
Authors: Gaston Sean
Published: October 2022

In January 2001 I received a letter from Jacques Derrida. The letter was a response to an article I had written about the concept of disinterest. What I did not know at the time was that he was in the midst of his seminar on the death penalty, which includes his most sustained interrogation of disinterest and interest. This essay examines the history of disinterest as a death penalty. Derrida challenges the possibility of such a history, arguing both for the madness of disinterest and the tenacity of another kind of interest. The essay also addresses Derrida’s letter and the problem of taking an interest in the interests of the other, of the right to interest, not least in Derrida’s own interests.
Institute of Phthisiopulmonology of the Ministry of Health
Authors: Dyakova S. Е. , Orlova E. A. , Klyukhina Y. B. , Kudinova T. V.
Published: October 2022

Modern functional diagnostics methods for the respiratory system in children (Part 1. Methods based on the study of tidal breathing in children) This review provides up-to-date information on practically significant functional diagnostics methods of the respiratory system in children, taking into account their physiological capabilities. In the published first part of the review, attention is paid to methods based on the study of tidal breathing in young children (tidal breathing flow-volume, computer bronchophonography, pulse oscillometry); this information is intended for functional diagnostics doctors, pulmonologists, neonatologists and pediatricians.
Performance Analysis of Deep Learning based Human Activity Recognition Methods
Authors: Aktter Mst. Farzana , Hossain Md Anwar , Sarker Sohag , Abadin AFM Zainul , Hasan Mirza AFM Rashidul
Published: October 2022

Human Activity Recognition (HAR) is one of the most important branches of human-centered research activities. Along with the development of artificial intelligence, deep learning techniques have gained remarkable success in computer vision. In recent years, there is a growing interest in Human Activity Recognition systems applied in healthcare, security surveillance, and human motion-based activities. A HAR system is essentially made of a wearable device equipped with a set of sensors (like accelerometers, gyroscopes, magnetometers, heart-rate sensors, etc.). Different methods are being applied for improving the accuracy and performance of the HAR system. In this paper, we implement Artificial Neural Network (ANN), and Convolutional Neural Network (CNN) in combination with Long Short-term Memory (LSTM) methods with different layers and compare their outputs towards the accuracy in the HAR system. We compare the accuracy of different HAR methods and observed that the performance of our proposed model of CNN 2 layers with LSTM 1 layer is the best.
Anti-value dimension of "The Leather Special" by Amy Schumer
Authors: Fedotova N. V.
Published: October 2022

This article analyzes the humorous aspect of the main anti-values in "The Leather Special" by Amy Schumer. The author identifies the following main ridiculed anti-values which are actualized in this humorous work: unattractiveness, drunkenness, lust and selfishness. In addition, the author also highlights the main characteristics of these ridiculed concepts. It should be noted that the majority of jokes in this stand-up special is devoted to sexual humor.
Department of Economics and Organization of Production: Beginning
Authors: Zolotarev I. I.
Published: October 2022

The circumstances of the initial stage of development of the Department of Economics and Production organization from the moment of its creation to its transformation into a graduate in the specialty "Economics and Management at the enterprise (in geodetic production)" are highlighted. The role of the department in the staffing of several newly created structural units of the university is reflected. The structure and personal composition of the staff and heads of the department are presented. Further deepening of research in this direction is proposed.
Feasibility study of the creation of a new business
Authors: Kruteeva O. V. , Lepilina V. V.
Published: October 2022

A feasibility study (feasibility study) of creating a new business is necessary for making informed management decisions and allows you to predict several scenarios for the development of the market situation. When calculating the feasibility study, it is important to plan the main parameters of the organization's activities; conduct a competitive analysis in the chosen field; calculate investments and other expenses; determine and justify economic efficiency; investigate the sensitivity of the project. Using the example of the opening of a sports studio, the main sections of the feasibility study are considered, the main indicators of the project are calculated.
The role of strategic master planning in the development of tourism and recreation in the Novosibirsk region
Authors: Ushakova E. O.
Published: October 2022

The purpose of this study is to analyze the application of the methodology of strategic master planning (territorial development strategy) in the field of recreation and tourism. The actual problems of organizational, economic and legal nature arising during strategic master planning are identified. The technology of master planning is analyzed, as well as the world and Russian experience in creating strategic master plans in the field of tourism and recreation. Despite the fact that this technique is intended to clarify the master plans of cities, it has recently also been used at the regional level for the spatial development of tourism, including the creation of tourist and recreational clusters. The article discusses the features of the development of master plans for the development of tourism in the Novosibirsk region. The master plan makes it possible to take into account not only the interests of the main participants in planning the socio-economic development of regions (government bodies), but also business structures and the local population (consumers of tourist services). In the modern sense, the master plan for tourism development is a strategic planning tool that is located at the junction between the master plan, socio-economic and spatial development strategies. The master plan is necessary to visualize the concept of using the resource potential of the territories, contributes to the creation of favorable conditions for the development of tourism and recreation.
Analysis of municipal policy in the field of development of sports and physical education in Novosibirsk
Authors: Aloyan M. S. , Loparev A. V. , Yudin D. S.
Published: October 2022

The article considers statistical data on sports and physical education events held in the city of Novosibirsk. The comparison of planned and actual indicators of the implementation of the development program in the field of physical education and sports was carried out.
Principles of Humanities and Methodological Features of Humanitarian Knowledge in the Information Society
Authors: Sotnikova E. V.
Published: October 2022

The article is devoted to the analysis of the specifics of humanitarian knowledge and cognition. The relevance of this study is due to the special role of education in the life of modern society, guided by the principles and values of the post-industrial era. The main tasks of the humanities at the present stage of the development of the information society are identified. The trans-disciplinary and meta-disciplinary approaches to humanitarian knowledge and education are considered as the fundamental methodological foundations of the modern stage of development of the humanities. Fundamental methodological changes in certain branches of humanitarian knowledge are identified as a response to globalization, information, and systemic changes in society. Conclusions are drawn about the status of humanitarian knowledge at the stage of permanent innovation and digitalization of society, about the interest in expert assessments confirming the reliability and assurance of knowledge and the results of its use, about the constructive possibilities of optimal integration of digital and humanitarian technologies.
Investment policy and development of higher education in Russia (1960s-1970s)
Authors: Stupina N. S. , Murenko D. I. , Makarenko N. N.
Published: October 2022

The historical aspect of the relationship between investment policy and policy in the field of higher education is considered. The main "problem areas" in the development of higher education of the described period are described. Attention is drawn to the negative consequences of using the so-called residual principle in relation to the formation of culture. The attempts of the country's leadership to overcome the investment crisis and replenish the budget, based on scientific and technological progress and the training of highly qualified personnel, are considered. The educational breakthrough of the late 1950s is shown, which was supposed to ensure the country's entry into the scientific and technological revolution. Emphasized: the inertia and inflexibility of the system of investment in scientific and technological revolution did not give the expected effect. Many specialists, including young specialists, turned out to be in little demand against the backdrop of a shortage of blue-collar jobs. Therefore, the growth in the number of people with a diploma of higher education in 1960-1970. led to the "devaluation" of diplomas, in the first place - engineering.
Analysis of stability of initial velocity of the shot of modern hunting and sports smoothbore cartridges
Authors: Коndratev S. А. , Кislin М. А. , Dubovin А. G. , Тraulko N. А. , Vikhareva N. А.
Published: October 2022

At present, a lot of work has been done to improve hunting and sports smoothbore cartridges. Much attention is paid to increasing the speed of the shot projectile without increasing the maximum pressure of the powder gases during the shot. The article analyzes the stability of the initial speed of the shot of modern hunting and sporting smoothbore cartridges.
Forming of an image of an extended absolutely absorbing slit hole with arbitrary opening in coherent light
Authors: Chugui Yu. V.
Published: October 2022

The features of forming an image of extended absolutely absorbing objects of constant thickness with arbitrary opening of holes have been studied in a coherent-optical system. On the base of the constructive approximation of the spectra of spatial frequencies (Fraunhofer difractional patterns) of objects with different dimensions relations front ( D ) and back ( D ) apertures, formulas for the field in the image of the front face were obtained and analyzed. Cases of objects with a noticeably expanding (bevel and noticeably narrowing apertures of an extended hole have been investigated in detail. It was found that in the case of large bevels, the structure of the image of the front face depends on the bevel sign (opening). With a positive reveal, when the back face is in the shadow region, the field at the output of the system corresponds to the image of the front face, and with a negative one, the image of the back face is observed. It is shown that error of determination of boundaries in image of active face of object is inversely proportional to square of its bevel. The invariant properties of the projection system for forming images of external faces of extended objects with large positive and negative bevels are analyzed.
Technology for manufacturing of reference calibration simulators of fuel pellets of pressurized water reactors
Authors: Bakakin G. V. , Dvoynishnikov S. V. , Pavlov V. A. , Rakhmanov V. V.
Published: October 2022

The work is devoted to the development of technology for the manufacture of reference calibration simulators of fuel pellets of pressurized water reactors. Reference calibration simulators of fuel pellets are necessary in the development of optoelectronic systems for monitoring the appearance and geometric dimensions of fuel pellets used in the production of uranium pellets. The article describes the developed technology for the manufacture of simulators, based on the manufacture of steel billets and subsequent multi-stage mechanochemical surface treatment based on blackening by the acid method.
Optical signal filtering method in three-component laser doppler anemometers
Authors: Rakhmanov V. V. , Pavlov V. A. , Bakakin G. V. , Dvoynishnikov S. V.
Published: October 2022

Methods for filtering signals in three-component laser Doppler anemometers for separating signals in optical paths of complementary devices are considered. A method is proposed for suppressing the mutual influence of signals based on the use of monochromatic sources of optical radiation with close wavelengths and bandpass optical filters. The possibility of implementing the proposed method of signals optical filtering in three-component laser Doppler anemometers using modern semiconductor laser diodes and bandpass optical filters is shown.
Effective use of solar collectors in heat supply systems in the Siberian region
Authors: Ivanchenko V. V. , Baranov V. A. , Vyatkina N. V. , Dorokhova N. M.
Published: October 2022

The article discusses the possibility of more efficient use of solar collectors and use in heat supply systems in the Siberian region. The symbiosis of storage and accumulation of solar energy is considered. The development of Novosibirsk scientists on methods of accumulating solar energy was studied, air and water solar collectors were manufactured, tested. It is concluded that collectors can be used to maintain plus energy indoor temperatures, use to heat water; the use of solar collectors may reduce heating costs, which will not be taxed on CO; the use of solar collectors can also significantly reduce the use of natural resources and, as a result, reduce the environmental burden on the environment. Practical significance: the results of the study can be used both in real everyday situations and in physics lessons when studying the transformation of energy and solving practical problems.
The use of a random number generator to develop a technique for predicting the departure of quantum clocks
Authors: Tissen V. M. , Balaсhnenko A. Yu. , Rachkov V. D.
Published: October 2022

The issues related to the development of models for predicting the divergence of scales of spatially dispersed quantum clocks are considered. The graphs of discrepancies between the scales of the onboard clocks of navigation satellites (NS) GLONASS and GPS relative to the scale of the central synchronizer are given. Mathematical models are proposed for predicting the departure of the onboard clock scales from the CA scale, consisting of three analytical components and an autoregression equation. The first two components analytically define linear and parabolic trends in the divergence of the scales. The third component is represented by a trigonometric polynomial with non-multiple harmonics. The parameters of all three components are estimated using the least squares method (OLS) based on the data of discrepancies in the NS clock scales individually for each NS. The forecast of residual stochastic changes is made using the autoregression equation. To work out forecasting models, it is proposed to use a software simulator of the instability process of quantum clocks.
Efectos del yoga en la calidad de vida de pacientes pediátricos con diagnóstico de cáncer: un estudio piloto
Authors: Sanhueza-Ramírez Massiel , Oyanadel Cristián , Peñate-Castro Wenceslao
Published: October 2022

Objetivo: Describir el efecto de un programa piloto de yoga en la calidad de vida de pacientes pediátricos con cáncer en tratamiento ambulatorio con quimioterapia.

Método: diseño mixto, cuasi-experimental, pre-post. Se reclutaron participantes entre 6 a 10 años, ocho completaron todo el programa. El programa consideró 6 sesiones grupales de Hatha yoga. Se utilizaron las escalas Calidad de Vida pediátrica versión genérica y específica del cáncer (Pediatric Quality of life inventory (PedsQl) 4.0 y 3.0). Se realiza una entrevista semi-estructurada para identificar beneficios percibidos por el/la cuidador/a.

Resultados: Los datos cuantitativos no muestran diferencias significativas en resultados de calidad de vida antes y después del programa, pero cualitativamente se reportaron beneficios en las entrevistas a cuidadores en las categorías del dolor, resistencia física y estado de ánimo.

Conclusiones: Este estudio piloto aporta a la implementación de futuras investigaciones que incorporen el yoga en oncología pediátrica en un entorno hospitalario.
One Film, Many Perspectives: Understanding The Issue Of Climate Change In The Documentary Film Before The Flood
Authors: Ayu Sabrina, Indra Kusumawardhana Mohamad Rosyidin,
Published: October 2022

There have been abundant literature concerning movies as a learning tool in International Relations (IR). The use of movies as a learning tool matters in order to achieve learning outcomes since movies could reduce the level of abstraction of a concept. This paper aims to explain the global climate change phenomenon depicted in a documentary film entitled Before the Flood using four main theoretical approaches in IR, namely, realism, neoliberal institutionalism, Marxism, and constructivism. This paper argues that Before the Flood is quite relevant and effective to achieve learning outcomes of IR theories course. Watching documentary films is expected to enrich learning methods in IR particularly IR theories courses by using audio-visual instruments
The United States Of America Withdrawal From Paris Agreement 2015: Desecuritization Of Climate
Authors: Fardha Dewi Shinta, Anita Afriani Sinulingga Maryam Jamilah,
Published: October 2022

The climate change issue has become a great debate in U.S foreign policy. Starting from the year 1980, the United States considered climate change one of the nation's potential threats. It can be traced from the U.S's active participation in climate change international regimes. But in 2015, Donald Trump's administration decided to withdraw from Paris Agreement. This research describes the securitization effort of climate change in the Donald Trump Administration through the U.S withdrawal from the Paris Agreement. The analysis uses four political forms of de securitization of Lene Hansen; stabilization, replacement, re-articulation, and silencing. This research is qualitative with a descriptive analysis approach. This research found that the climate change de securitization in Donald Trump's administration uses the four political forms: stabilize climate change issues, replace climate change with the economic, immigrant, and terrorist Issues, and rearticulate the danger of other three subjects. However, it can be concluded that the silencing effort was not complete; it can be proved by establishing the U.S Coalition of societies (We are still in) which supports the Paris Agreement 2015, and some protests of the American public against Donald Trump's decision
Soft adaptation: The role of social capital in building resilient agricultural landscapes
Authors: De Grandpré Ayla , Elton Chea , Senese Donna , Mullinix Kent
Published: October 2022

The resilience of agricultural production is perpetually challenged by a wide range of disturbances from the impacts of climate change, to political instability and urbanization. At the same time, agriculture production also depends on relatively stable socio-ecological conditions to ensure quality and yield. Understanding how producers in agricultural landscapes can increase adaptive capacity, and remain resilient in the face of these challenges has become a priority for farmers, for researchers and national political agendas on a global scale. The current state of knowledge on adaptation tends to focus overwhelmingly on “hard” adaptation, such as infrastructure and technological inputs, rather than “softer” strategies, such as agroecological management or social capital, which are less easily measured. This research aims to explore soft strategies for adaptive capacity, in particular, the effect of social capital on the adaptive capacity of agricultural systems, using a case study of the agricultural landscape in the Okanagan Bioregion. The findings suggest that soft adaptation is a vital strategy for cultivating agricultural resilience, and underpins the ability of producers to use other soft and hard adaptation strategies. Participants in this research highlighted the importance of social connection, networks, reciprocity, learning and knowledge transferral, as key tools used to increase their adaptive capacity. They also highlight social capital as a building block for other forms of capital, such as financial, physical and environmental capitals. Despite this importance of soft adaptation, participants also indicated that they would be more likely to focus on implementing “harder” strategies that respond more directly and tangibly to key disturbances, rather than “soft” strategies. These results suggest a contradiction between the importance and value that producers place on social capital and “soft” adaptation, and the strategies they actually plan to implement. Further research is required to understand this contradiction, and to explore how to communicate the value of “soft” adaptation to producers in a way that makes the benefits more concrete and observable, and allows them to capitalize on the currency of connection.
Dynamic and static biomechanical traits of cardiac fibrosis
Authors: Liu Han , Fan Pengbei , Jin Fanli , Huang Guoyou , Guo Xiaogang , Xu Feng
Published: October 2022

Cardiac fibrosis is a common pathology in cardiovascular diseases which are reported as the leading cause of death globally. In recent decades, accumulating evidence has shown that the biomechanical traits of fibrosis play important roles in cardiac fibrosis initiation, progression and treatment. In this review, we summarize the four main distinct biomechanical traits (i.e., stretch, fluid shear stress, ECM microarchitecture, and ECM stiffness) and categorize them into two different types (i.e., static and dynamic), mainly consulting the unique characteristic of the heart. Moreover, we also provide a comprehensive overview of the effect of different biomechanical traits on cardiac fibrosis, their transduction mechanisms, and in-vitro engineered models targeting biomechanical traits that will aid the identification and prediction of mechano-based therapeutic targets to ameliorate cardiac fibrosis.
Corrigendum: Microalgae-based wastewater treatment for developing economic and environmental sustainability: Current status and future prospects
Authors: Srimongkol Piroonporn , Sangtanoo Papassara , Songserm Pajareeya , Watsuntorn Wannapawn , Karnchanatat Aphichart
Published: October 2022

Graphical Abstract

A biorefinery based on microalgae promotes a circular-green economic model.
Porcn is essential for growth and invagination of the mammalian optic cup
Authors: Fuhrmann Sabine , Ramirez Sara , Mina Abouda Mirna , Campbell Clorissa D.
Published: October 2022

Microphthalmia, anophthalmia, and coloboma (MAC) are congenital ocular malformations causing 25% of childhood blindness. The X-linked disorder Focal Dermal Hypoplasia (FDH) is frequently associated with MAC and results from mutations in Porcn, a membrane bound O-acyl transferase required for palmitoylation of Wnts to activate multiple Wnt-dependent pathways. Wnt/β-catenin signaling is suppressed in the anterior neural plate for initiation of eye formation and is subsequently required during differentiation of the retinal pigment epithelium (RPE). Non-canonical Wnts are critical for early eye formation in frog and zebrafish. However, it is unclear whether this also applies to mammals. We performed ubiquitous conditional inactivation of Porcn in mouse around the eye field stage. In PorcnCKO, optic vesicles (OV) arrest in growth and fail to form an optic cup. Ventral proliferation is significantly decreased in the mutant OV, with a concomitant increase in apoptotic cell death. While pan-ocular transcription factors such as PAX6, SIX3, LHX2, and PAX2 are present, indicative of maintenance of OV identity, regional expression of VSX2, MITF, OTX2, and NR2F2 is downregulated. Failure of RPE differentiation in PorcnCKO is consistent with downregulation of the Wnt/β-catenin effector LEF1, starting around 2.5 days after inactivation. This suggests that Porcn inactivation affects signaling later than a potential requirement for Wnts to promote eye field formation. Altogether, our data shows a novel requirement for Porcn in regulating growth and morphogenesis of the OV, likely by controlling proliferation and survival. In FDH patients with ocular manifestations, growth deficiency during early ocular morphogenesis may be the underlying cause for microphthalmia.
Identification and characterization of alternative sites and molecular probes for SARS-CoV-2 target proteins
Authors: Iyengar Suhasini M. , Barnsley Kelly K. , Vu Hoang Yen , Bongalonta Ian Jef A. , Herrod Alyssa S. , Scott Jasmine A. , Ondrechen Mary Jo
Published: October 2022

Three protein targets from SARS-CoV-2, the viral pathogen that causes COVID-19, are studied: the main protease, the 2′-O-RNA methyltransferase, and the nucleocapsid (N) protein. For the main protease, the nucleophilicity of the catalytic cysteine C145 is enabled by coupling to three histidine residues, H163 and H164 and catalytic dyad partner H41. These electrostatic couplings enable significant population of the deprotonated state of C145. For the RNA methyltransferase, the catalytic lysine K6968 that serves as a Brønsted base has significant population of its deprotonated state via strong coupling with K6844 and Y6845. For the main protease, Partial Order Optimum Likelihood (POOL) predicts two clusters of biochemically active residues; one includes the catalytic H41 and C145 and neighboring residues. The other surrounds a second pocket adjacent to the catalytic site and includes S1 residues F140, L141, H163, E166, and H172 and also S2 residue D187. This secondary recognition site could serve as an alternative target for the design of molecular probes. From in silico screening of library compounds, ligands with predicted affinity for the secondary site are reported. For the NSP16-NSP10 complex that comprises the RNA methyltransferase, three different sites are predicted. One is the catalytic core at the conserved K-D-K-E motif that includes catalytic residues D6928, K6968, and E7001 plus K6844. The second site surrounds the catalytic core and consists of Y6845, C6849, I6866, H6867, F6868, V6894, D6895, D6897, I6926, S6927, Y6930, and K6935. The third is located at the heterodimer interface. Ligands predicted to have high affinity for the first or second sites are reported. Three sites are also predicted for the nucleocapsid protein. This work uncovers key interactions that contribute to the function of the three viral proteins and also suggests alternative sites for ligand design.
Evaluation of the in vitro antioxidant and antitumor activity of extracts from Camellia fascicularis leaves
Authors: Peng Xiaowei , He Xuhua , Tang Junrong , Xiang Jianying , Deng Jia , Kan Huan , Zhang Yingjun , Zhang Guiliang , Zhao Ping , Liu Yun
Published: October 2022

Camellia fascicularis is a unique plant rich in bioactive components. However, the isolation of the active substances in C. fascicularis leaves via sequential extraction with solvents of different polarity and the determination of their antioxidant and antitumor activities have not been reported. In this study, the total methanol extract of C. fascicularis leaves was sequentially extracted with different polar solvents, and the corresponding petroleum ether extract (PEE), ethyl acetate extract (EAE), and water extract (WE) were analyzed for their contents in active substances such as flavonoids, polyphenols, polysaccharides, and saponins. The antioxidant ability of the polar extracts was investigated by determining their reducing power and the radical scavenging rate on 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), and hydroxyl radicals, and CCK-8 and Annexin-FITC/propidium iodide staining assays were conducted to investigate their inhibitory effects on HCCLM6 and HGC27 tumor cells. The results showed that PEE had a high saponin content of 197.35 ± 16.21 mg OAE/g, while EAE and WE exhibited a relatively higher polysaccharide content of 254.37 ± 1.99 and 373.27 ± 8.67 mg GE/g, respectively. The EAE demonstrated the greatest reducing power and the strongest clearing abilities on ABTS and DPPH radicals with respective EC50 values of 343.45 ± 20.12 and 14.07 ± 0.06 μg/ml. Moreover, the antitumor ability of the different polar extracts was dose-dependent, with WE showing the most potent inhibitory ability against HCCLM6 and HGC27 cells.
High-resolution flexible X-ray luminescence imaging enabled by eco-friendly CuI scintillators
Authors: Hong Zhongzhu , Luo Peifu , Wu Tingting , Wu Qinxia , Chen Xiaoling , Yang Zhijian , Dai Shuheng , Jiang Hao , Chen Qihao , Sun Qiang , Xie Lili
Published: October 2022

Solution-processed scintillators hold great promise in fabrication of low-cost X-ray detectors. However, state of the art of these scintillators is still challenging in their environmental toxicity and instability. In this study, we develop a class of tetradecagonal CuI microcrystals as highly stable, eco-friendly, and low-cost scintillators that exhibit intense radioluminescence under X-ray irradiation. The red broadband emission is attributed to the recombination of self-trapped excitons in CuI microcrystals. We demonstrate the incorporation of such CuI microscintillator into a flexible polymer to fabricate an X-ray detector for high-resolution imaging with a spatial resolution up to 20 line pairs per millimeter (lp mm−1), which enables sharp image effects by attaching the flexible imaging detectors onto curved object surfaces.
P3 problem and Magnolia language: Specializing array computations for emerging architectures
Authors: Chetioui Benjamin , Larnøy Marius Kleppe , Järvi Jaakko , Haveraaen Magne , Mullin Lenore
Published: October 2022

The problem of producing portable high-performance computing (HPC) software that is cheap to develop and maintain is called the P3 (performance, portability, productivity) problem. Good solutions to the P3 problem have been achieved when the performance profiles of the target machines have been similar. The variety of HPC architectures is, however, large and can be expected to grow larger. Software for HPC therefore needs to be highly adaptable, and there is a pressing need to provide developers with tools to produce software that can target machines with vastly different profiles. Multi-dimensional array manipulation constitutes a core component of numerous numerical methods, such as finite difference solvers of Partial Differential Equations (PDEs). The efficiency of these computations is tightly connected to traversing and distributing array data in a hardware-friendly way. The Mathematics of Arrays (MoA) allows for formally reasoning about array computations and enables systematic transformations of array-based programs, e.g., to use data layouts that fit to a specific architecture. This paper presents a programming methodology aimed for tackling the P3 problem in domains that are well-explored using Magnolia, a language designed to embody generic programming. The Magnolia programmer can restrict the semantic properties of abstract generic types and operations by defining so-called axioms. Axioms can be used to produce tests for concrete implementations of specifications, for formal verification, or to perform semantics-preserving program transformations. We leverage Magnolia's semantic specification facilities to extend the Magnolia compiler with a term rewriting system. We implement MoA's transformation rules in Magnolia, and demonstrate through a case study on a finite difference solver of PDEs how our rewriting system allows exploring the space of possible optimizations.