bluuebunny/crossref_metadata_2025 huggingface dataset:
ChemInform Abstract: Chloride Derivatives of Lanthanide ortho‐Oxomolybdates: Part 3. Crystal Structures, Spectroscopic Studies, and Magnetic Properties of the LnCl[MoO4] Representatives with the Large Lanthanides (Ln: La, Ce, Pr).
Authors: Hartenbach Ingo , Schleid Thomas , Strobel Sabine , Dorhout Peter K.
Published: August 2010

The title compounds are prepared from mixtures of LnCl3 (Ln: La, Ce, Pr), Ln2O3, and MoO3 in molar ratios of 1:1:3 (900 °C, 6 d) and characterized by powder XRD, single crystal XRD, Raman spectroscopy, and magnetic measurements.
ChemInform Abstract: The New Neodymium(II) Oxide Chloride Oxoselenate(IV) Nd7O5Cl3[SeO3]4.
Authors: Zitzer Sabine , Schleid Thomas
Published: August 2010

Pale violet, needle‐shaped single crystals of the title compound are prepared from mixtures of Nd2O3, NdCl3, and SeO2 in the molar ratio of 3:1:4 using CsCl as a flux (silica ampule, 775 °C, 7 d).
ChemInform Abstract: Synthesis, Characterization, and Computational Study of MoSF4.
Authors: Nieboer jared , Mack Johnathan P. , Mercier Helene P. A. , Gerken Michael
Published: August 2010

MoSF4 is synthesized from a slight excess of MoF6 and S(SiMe3)2 in CFCl3 (‐120 °C, 86% yield) and characterized by Raman, IR, and 19F NMR spectroscopy, and by single crystal XRD.
ChemInform Abstract: Ethyl 5‐Chloro‐2‐oxopent‐3‐ynoate, a New Acetylenic Dienophile in the Diels—Alder Reactions.
Authors: Koldobskii A. B. , Shilova O. S. , Godovikov I. A. , Kalinin V. N.
Published: August 2010

Treatment of the lithium salt of propargyl chloride (I) with diethyl oxalate (II) at low temperatures under strictly controlled conditions provides the previously unknown ester (III) which undergoes Diels—Alder reactions with conjugated dienes.
ChemInform Abstract: Gold‐Catalyzed Dealkoxylative Carbocyclization/[3 + 3] Annulation Cascade of Acetal—Allene or Ketal—Allene Substrates.
Authors: Teng Tse‐Min , Lin Ming‐Shiun , Vasu Dhananjayan , Bhunia Sabyasachi , Liu Ting‐An , Liu Rai‐Shung
Published: August 2010

Acetal‐allene or ketal‐allene compounds undergo the title cascade reaction with 2‐substituted allylsilanes, a phenol, or enolizable ketones to give a wide variety of tri‐ and tetracyclic carbocycles as well as oxapolycyclic compounds with good stereocontrol in general.
ChemInform Abstract: Ring Opening of Cyclic Vinylogous Acyl Triflates Using Stabilized Carbanion Nucleophiles: Claisen Condensation Linked to Carbon—Carbon Bond Cleavage.
Authors: Jones David M. , Lisboa Marilda P. , Kamijo Shin , Dudley Gregory B.
Published: August 2010

Treatment of the cyclic triflates (I) and (VII) with carbanion nucleophiles provides acyclic alkynes bearing 1,3‐diketone, β‐keto ester, β‐keto phosphonate, or β‐keto phosphine oxide moieties.
ChemInform Abstract: Mild Arming and Derivatization of Natural Products via an In(OTf)3‐Catalyzed Arene Iodination.
Authors: Zhou Cong‐Ying , Li Jing , Peddibhotla Satyamaheshwar , Romo Daniel
Published: August 2010

Bacterial protein synthesis inhibitor anisomycin is not reactive, but its N‐Boc derivative (XVII) affords the expected iodide (XVIII) in high yield.
ChemInform Abstract: Asymmetric Rh(I)‐Catalyzed Addition of MIDA Boronates to N‐tert‐Butanesulfinyl Aldimines: Development and Comparison to Trifluoroborates.
Authors: Brak Katrien , Ellman Jonathan A.
Published: August 2010

The MIDA boronates are efficient coupling partners which allow formation of α‐branched amines in good yields with excellent enantioselectivity.
ChemInform Abstract: A Versatile Approach to 2‐Substituted 3‐Trifluoromethyl‐1,3‐diols Based on the Reaction of Trifluoroacetaldehyde Ethyl Hemiacetal with Enamines Derived from Aldehydes.
Authors: Funabiki Kazumasa , Furuno Yudai , Sato Fumiaki , Gonda Hiroshi , Kubota Yasuhiro , Matsui Masaki
Published: August 2010

The reaction of enamine (I) with ethyl hemiacetal (II) followed by acid hydrolysis and subsequent reduction of the intermediate aldehyde gives rise to the diastereomeric mixture of diols (III) and (IV).
ChemInform Abstract: Carbamoylation of Aryl Halides by Molybdenum or Tungsten Carbonyl Amine Complexes.
Authors: Ren Wei , Yamane Motoki
Published: August 2010

It provides a simple approach to aromatic and heteroaromatic amides.
ChemInform Abstract: The 1,3‐Diaminobenzene‐Derived Aminophosphine Palladium Pincer Complex {C6H3 [NHP(piperidinyl)2]2Pd(Cl)} — A Highly Active Suzuki—Miyaura Catalyst with Excellent Functional Group Tolerance.
Authors: Bolliger Jeanne L. , Frech Christian M.
Published: August 2010

The new protocol is an improvement over previously reported methods due to its significantly broadened applicability.
ChemInform Abstract: Palladium‐Catalyzed Cross‐Coupling of 2,3‐Naphthoxadisilole with Aryl Halides.
Authors: Ding Han , Chen Yali , Cao Weiguo , Wu Kaicheng , Chen Jie , Lee Albert W. M.
Published: August 2010

For the first time oxadisilole is used as partner in the palladium‐catalyzed cross‐coupling reaction.
ChemInform Abstract: Rapid Access to 1‐Methyleneindenes via Palladium‐Catalyzed Tandem Reactions of 1‐(2,2‐Dibromovinyl)‐2‐alkynylbenzenes with Arylboronic Acids.
Authors: Ye Shengqing , Yang Xiaodi , Wu Jie
Published: August 2010

The novel route to title compounds, e.g. (III), proceeds under mild conditions and with high selectivity.
ChemInform Abstract: Facile Synthesis of 3‐Nitro‐2‐substituted Thiophenes
Authors: O'Connor Cornelius J. , Roydhouse Mark D. , Przybyl Anna M. , Wall Michael D. , Southern J. Mike
Published: August 2010

based on a tandem Michael—intramolecular Henry reaction
ChemInform Abstract: Triethanolamine‐Mediated Palladium‐Catalyzed Regioselective C‐2 Direct Arylation of Free NH‐Pyrroles.
Authors: Jafarpour Farnaz , Rahiminejadan Soraya , Hazrati Hamideh
Published: August 2010

The straightforward and cost‐effective approach can also be applied to N‐substituted pyrroles.
ChemInform Abstract: Ene Reactions Between Two Alkynes? Doors Open to Thermally Induced Cycloisomerization of Macrocyclic Triynes and Enediynes.
Authors: Gonzalez Ivan , Pla‐Quintana Anna , Roglans Anna , Dachs Anna , Sola Miquel , Parella Teodor , Farjas Jordi , Roura Pere , Lloveras Vega , Vidal‐Gancedo Jose
Published: August 2010

A domino process is described combining an ene reaction between two alkynes and a Diels—Alder cycloaddition of the vinylallene formed.
ChemInform Abstract: The Application of Poly(N,N′‐dibromo‐N‐ethyl‐benzene‐1,3‐disulfonamide) and N,N,N′,N′‐Tetrabromobenzene‐1,3‐disulfonamide as Catalysts for One‐Pot Synthesis of 2‐Aryl‐1‐arylmethyl‐1H‐1,3‐benzimidazoles and 1,5‐Benzodiazepines, and New Reagents for Synthesis of Benzimidazoles.
Authors: Ghorbani‐Vaghei Ramin , Veisi Hojat
Published: August 2010

TBBDA and its polymeric analogue PBBS are found to promote the condensation of o‐phenylene diamine (I) with aldehydes and ketones under various conditions.
ChemInform Abstract: Synthesis and Antidepressant Evaluation of Five Novel Heterocyclic Tryptophan‐Hybrid Derivatives.
Authors: Elmegeed Gamal A. , Baiuomy Ayman R. , Abdelhalim Mervat M. , Hana Hanaa Y.
Published: August 2010

Facile syntheses of new bi‐ and triheterocyclic tryptophan‐hybrid systems are given.
ChemInform Abstract: Preparation of Substituted Oxazoles by Ritter Reactions of α‐Oxo Tosylates.
Authors: Lai Ping‐Shan , Taylor Mark S.
Published: August 2010

Lewis acid catalyzed Ritter reaction of α‐oxo tosylates, trifluoroacetates and alcohols with nitriles under optimized conditions affords trisubstituted oxazole products in good to excellent yields.
ChemInform Abstract: Solvent‐Free Multicomponent Synthesis of Pyranopyrazoles: Per‐6‐amino‐β‐cyclodextrin as a Remarkable Catalyst and Host.
Authors: Kanagaraj Kuppusamy , Pitchumani Kasi
Published: August 2010

The method is highly efficient, since it needs only a very small amount of PAC.
ChemInform Abstract: Synthesis of Substituted Methyl 5,5‐Polymethylene‐2,4‐dioxotetrahydropyran‐3‐carboxylates.
Authors: Kirillov N. F. , Melekhin V. S. , Shurov S. N. , Plotnikov A. V. , Vakhrin M. I. , Maiorova O. A.
Published: August 2010

The title compounds (VI) (8 examples) are obtained in the reaction of malonates (IV) with zinc and several aromatic aldehydes (V).
ChemInform Abstract: Synthesis and Some Transformations of 6(8)‐Substituted 4‐Hydrazino‐2‐methylquinolines.
Authors: Avetisyan A. A. , Aleksanyan I. L. , Ambartsumyan L. P.
Published: August 2010

The title compounds (III) are obtained by reaction of the corresponding 4‐chloro‐2‐methylquinolines (I) with hydrazine hydrate.
ChemInform Abstract: Synthesis of Highly Substituted Cyclobutane Fused‐Ring Systems from N‐Vinyl β‐Lactams Through a One‐Pot Domino Process.
Authors: Cheung Lawrence L. W. , Yudin Andrei K.
Published: August 2010

A domino [3.3]‐rearrangement/6π‐electrocyclization process furnishes highly substituted pyridine‐fused cyclobutane derivatives and thus provides an promising method for preparation of fused heterocycles.
ChemInform Abstract: 3‐Substituted 2‐Trifluoromethylimidazo[1,2‐a]pyridines.
Authors: Sokolov V. B. , Aksinenko A. Yu. , Epishina T. A. , Goreva T. V.
Published: August 2010

Previously unknown 3‐fluoro‐2‐trifluoromethylimidazo[1,2‐a]pyridines (IV) are synthesized via cyclization of readily available imines (III).
ChemInform Abstract: Synthesis of a Novel Tricyclic 1,2,3,4,4a,5,6,10b‐Octahydro‐1,10‐phenanthroline Ring System and CXCR4 Antagonists with Potent Activity Against HIV‐1.
Authors: Catalano John G. , et al. et al.
Published: August 2010

Stereorandom and diastereoselective syntheses of novel title ring system are described.
ChemInform Abstract: Properties of 3,3‐Dialkyl‐3,4‐dihydroisoquinoline Cyclic Azomethines.
Authors: Surikova O. V. , Mikhailovskii A. G. , Vakhrin M. I.
Published: August 2010

Reaction of the title dihydroisoquinolines (I) with esters or amides of iodoacetic acid gives stable quaternary ammonium salts (III), which appear to be suitable dipoles in [3 + 2] cycloaddition reactions.
ChemInform Abstract: A Novel and Efficient One‐Pot Synthesis of 2‐Aminopyrimidinones and Their Self‐Assembly.
Authors: Bararjanian Morteza , Balalaie Saeed , Rominger Frank , Barouti Sanaz
Published: August 2010

A three‐component reaction of benzaldehydes, cyanoacetate and guanidinium carbonate affords the pyrimidine derivatives (10 examples).
ChemInform Abstract: Synthesis of Pyrimido[1,2‐a]benzimidazoles from Ethyl 2‐Ethoxymethylidene‐3‐oxo‐3‐(polyfluoroalkyl)propionates.
Authors: Goryaeva M. V. , Burgart Ya. V. , Saloutin V. I.
Published: August 2010

The cyclization of polyfluoroalkylpropionates (I) with benzimidazol‐2‐amine (II) follows two concurrent pathways with participation of the fluoroacyl or ethoxycarbonyl fragments, respectively.
ChemInform Abstract: Synthesis of Unexpected Pyrrolo[2,3‐b]quinoxaline‐2‐carbaldehydes via Sonogashira Coupling Reaction.
Authors: Keivanloo Ali , Bakherad Mohammad , Rahimi Amin
Published: August 2010

Pd‐catalyzed reaction of 3‐chloroquinoxalin‐2‐amines with propargyl bromide proceeds in the presence of wet morpholine to give the title compounds (III) unexpectedly.
ChemInform Abstract: Ketene Organoelement Derivatives. Synthesis of Bis(1‐R‐2‐oxovinyl)silanes and Germanes (R: SiMe3, GeMe3, SnMe3).
Authors: Gruener S. V. , Ezhov R. N. , Petrosyan V. S.
Published: August 2010

Earlier unknown 1,3‐bisketene organo‐element compounds (III) are synthesized.
ChemInform Abstract: Hydrazinophosphonates and Hydrazinobisphosphonates: Novel Mitsunobu and Arbuzov‐Type Multicomponent Application of the Morrison—Brunn—Huisgen Betaine.
Authors: Alizadeh Abdolali , Rostamnia Sadegh
Published: August 2010

The reaction of the zwitterion, generated from DIAD and trialkylphosphite, with aroyl, phosphoryl, and sulfonyl chlorides produces the expected fully substituted hydrazines in good to excellent yields.
ChemInform Abstract: Synthesis and Biological Activity of New 2‐[(3‐Aminopropyl)dimethylsilyl]‐5‐trialkylgermylfurans.
Authors: Ignatovich L. , Romanovs V. , Shestakova I. , Domrachova I. , Popelis J. , Lukevics E.
Published: August 2010

Most of the synthesized title compounds (III) (20 examples) exhibit high cytotoxic activity.
ChemInform Abstract: Dermacozines, a New Phenazine Family from Deep‐Sea Dermacocci Isolated from a Mariana Trench Sediment
Authors: Jaspars Marcel , et al. et al.
Published: August 2010

isolation, structure elucidation and cytotoxicity screening of dermacozines A (Ia), B (Ib), C (Ic), D (II), E (IIIa), F (IIIb) and G (IIIc)
ChemInform Abstract: Five New 2‐Arylbenzofuran Derivatives from Morus wittiorum
Authors: Tan Yong‐Xia , Gong Ting , Liu Chao , Chen Ruo‐Yun , Yu De‐Quan
Published: August 2010

structure, antioxidant and antiinflammatory activities of wittifurans A‐C (Ia)‐(Ic), F (Id) and G (Ie)
ChemInform Abstract: Mechanisms, Kinetics, and Dynamics of Oxidation and Reactions on Oxide Surfaces Investigated by Scanning Probe Microscopy
Authors: Altman Eric , Schwarz Udo D.
Published: August 2010

Review: 116 refs.
ChemInform Abstract: Electronic and Magnetic Properties of SrTiO3/LaAlO3 Interfaces from First Principles
Authors: Chen Hanghui , Kolpak Alexie M. , Ismail‐Beigi Sohrab
Published: August 2010

Review: 75 refs.
ChemInform Abstract: Development of Unique Chemical Phenomena within Nanometer‐Sized, Self‐Assembled Coordination Hosts
Authors: Yoshizawa Michito , Fujita Makoto
Published: August 2010

Review: 40 refs.
ChemInform Abstract: Footsteps of a Fluorine Chemist
Authors: Chambers Richard D.
Published: August 2010

Review: 48 refs.
ChemInform Abstract: Amino Acid Ligand Chirality for Enantioselective Syntheses
Authors: Micskei Karoly , Patonay Tamas , Caglioti Luciano , Palyi Gyula
Published: August 2010

Review: 105 refs.
ChemInform Abstract: Nucleophilic Substitutions of Nitroarenes and Pyridines: New Insight and New Applications
Authors: Schlosser Manfred , Ruzziconi Renzo
Published: August 2010

Review: 116 refs.
ChemInform Abstract: Well‐Defined Surface Rhodium Siloxide Complexes and Their Application to Catalysis
Authors: Marciniec Bogdan , Potrzebowski Marek J. , Kownacki Ireneusz , Szubert Karol
Published: August 2010

Review: 71 refs.
ChemInform Abstract: Fullerene‐Mediated Activation of Dihydrogen: A New Method of Metal‐Free Catalytic Hydrogenation
Authors: Niemeyer Jochen , Erker Gerhard
Published: August 2010

Review: 44 refs.
ChemInform Abstract: Transition Metal Mediated [2+2+2] Cycloadditions
Authors: Leboeuf David , Gandon Vincent , Malacria Max
Published: August 2010

Review: 174 refs.
ChemInform Abstract: Cyclic Coupling Reactions
Authors: Jiang Xuefeng , Ma Shengming
Published: August 2010

Review: 161 refs.
ChemInform Abstract: Transition Metal Catalyzed Intramolecular Allylation Reactions
Authors: Lu Zhan , Ma Shengming
Published: August 2010

Review: 137 refs.
ChemInform Abstract: Cyclization of Aromatic Polyketides from Bacteria and Fungi
Authors: Zhou Hui , Li Yanran , Tang Yi
Published: August 2010

Review: 205 refs.
A simple chromatographic route for the isolation of meso diaminopimelic acid
Authors: Tóth Gábor K. , Hetényi Anasztázia , Ilisz István , Péter Antal
Published: August 2010

Meso diaminopimelic acid is an important noncoded amino acid found in Gram‐negative bacterial peptidoglycan. In spite of its importance, this stereoisomer is not available commercially. A simple, economical procedure was developed for the isolation of pure meso diaminopimelic acid via an high‐performance liquid chromatography separation. In our new approach, the underivatized three isomers of diaminopimelic acid were separated on a crown ether‐based chiral stationary phase. For the structure identification, 1H NMR spectroscopy was applied. Chirality, 2011. © 2010 Wiley‐Liss, Inc.
Incorporation of Heavy Metals Bioavailability into Risk Characterization
Authors: Ryu Hyerim , Chung Jae Shik , Nam Taekwoo , Moon Hee Sun , Nam Kyoungphile
Published: August 2010

The bioavailability of field‐aged Cd and Cu was calculated, and compared to the total concentrations determined by acid digestion. Only 0.60–4.15% for Cd and 0.59–9.43% for Cu were found to be bioavailable when determined by stomach‐phase extraction. The incorporation of bioavailability reduced more than 90% of the calculated risk of the metals at the site of study. It should be noted that such a reduction may not be generalized and the site‐specific bioavailability needs to be determined case by case.
Effect of radiotherapy boost and hypofractionation on outcomes in ductal carcinoma in situ
Authors: Wai Elaine S. , Lesperance Mary L. , Alexander Cheryl S. , Truong Pauline T. , Culp Matthew , Moccia Patricia , Lindquist Jennifer F. , Olivotto Ivo A.
Published: August 2010

BACKGROUND:

Boost radiotherapy (RT) improves outcomes for patients with invasive breast cancer, but whether this is applicable to patients with pure ductal carcinoma in situ (DCIS) is unclear. This study examined outcomes from whole breast RT, with or without a boost, and the impact of different dose‐fractionation schedules in a population‐based cohort of women with pure DCIS treated with breast‐conserving surgery (BCS).

METHODS:

Data was analyzed for 957 subjects diagnosed between 1985 and 1999. RT use was analyzed over time. Ten‐year Kaplan‐Meier local control (LC), breast cancer specific survival (BCSS), and overall survival (OS) were compared using the log‐rank test. Cox regression modeling of LC was performed.

RESULTS:

Median follow‐up was 9.3 years. Of the patient cohort 475 (50%) had no RT (NoRT) after BCS, 338 (35%) had RT without a partial breast boost (RTNoB), and 144 (15%) had RT with boost (RT + B). Subjects with risk factors of local recurrence were more likely to receive RT. Subjects receiving adjuvant RT had a trend toward improved LC (15‐year LC: NoRT 87%; RTNoB 94%; RT + B 91%; P = .065). Multivariable analysis showed that RT with or without a boost was significantly associated with improved LC (HR, 0.29 and 0.38, respectively, compared with NoRT, P = .025), with no difference associated with a boost or different dose‐fractionation schedules.

CONCLUSIONS:

Adjuvant RT improves local control in patients with DCIS treated with BCS. Hypofractionation is as effective as standard fractionation schedules. Boost RT was not associated with improved LC compared with whole breast RT alone. Cancer 2011. © 2010 American Cancer Society.
Zoledronic acid use in cancer patients
Authors: Coleman Robert , Cook Richard , Hirsh Vera , Major Pierre , Lipton Allan
Published: August 2010

Bone is the most common site for metastasis from solid tumors, and the majority of patients will develop bone metastases during the natural course of their disease. Bisphosphonates are an effective treatment for preventing skeletal‐related events in patients with bone metastases and may preserve functional independence and quality of life. Although several bisphosphonates have been investigated in patients with solid tumors, only zoledronic acid (ZOL) is approved by the US Food and Drug Administration and the European Medicines Agency for preventing skeletal‐related events in patients across a broad range of solid tumors. In addition, bisphosphonates, notably ZOL, prevent cancer treatment‐induced bone loss in breast and prostate cancer patients who are receiving endocrine therapy. It also has been demonstrated that ZOL directly and indirectly inhibits cancer cell growth in vitro and growth and tumorigenesis in animal model systems. These properties may produce clinically meaningful benefits. In recent clinical studies in patients with cancer, ZOL improved overall and prolonged disease‐free survival. Ongoing clinical trials in patients with solid tumors will provide further insight into the potential of ZOL to prevent distant metastases and improve survival. Cancer 2011. © 2010 American Cancer Society.
Characteristics of the coexistence of melanoma and renal cell carcinoma
Authors: Maubec Eve , Chaudru Valérie , Mohamdi Hamida , Grange Florent , Patard Jean‐Jacques , Dalle Stéphane , Crickx Béatrice , Paillerets Brigitte Bressac‐de , Demenais Florence , Avril Marie‐Françoise
Published: August 2010

BACKGROUND:

Patients with melanoma (MM) have an increased risk of kidney cancer, and there is an excess risk of MM among patients with renal cell carcinoma (RCC). The objective of the current study was to analyze a series of 42 patients with both MM and RCC to identify clinical and pathologic features as well as risk factors of this association.

METHODS:

Clinical and pathologic characteristics of 42 patients who developed both MM and RCC (the MM + RCC series) were compared with 2 published series in each cancer alone: a series of 293 patients with MM (MM series) and a series of 1527 patients with RCC (RCC series).

RESULTS:

RCC was diagnosed concomitantly or after MM in 83% of patients in the MM + RCC series. Those patients displayed a high proportion of asymptomatic RCC at diagnosis (70%) and a higher frequency of stage I tumors (61%) than patients in the RCC series. Compared with the MM series, patients in the MM + RCC series more often were men, had a higher frequency of blond/red hair, had poor tanning ability, and had a higher number of nevi. In addition, patients in the MM + RCC series had a high aggregation of other malignancies (mainly skin cancers) and a significantly higher frequency of family history of MM (P = .005). Only 2 cyclin‐dependent kinase 2A gene (CDKN2A) germline mutations were identified among patients in the MM + RCC series who also were members of MM‐prone families.

CONCLUSIONS:

The high aggregation of cancers among patients in the MM + RCC series and the familial clustering of MM argued for a genetic predisposition that may be partly independent of CDKN2A. Cancer 2010. © 2010 American Cancer Society.
Clinical outcomes for patients with soft tissue sarcoma of the hand
Authors: Puhaindran Mark E. , Rohde Rachel S. , Chou Joanne , Morris Carol D. , Athanasian Edward A.
Published: August 2010

BACKGROUND:

In an earlier report from the current study center regarding surgical treatment for patients with soft tissue sarcoma (STS) of the hand, it was concluded that repeat resection or amputation improves outcomes. Since then, the authors have aggressively sought to achieve negative resection margins, using standard or modified amputations when needed, and performing repeat resections to negative surgical margins when they were not achieved at the time of initial surgery. The current review was conducted to determine whether this approach resulted in better outcomes.

METHODS:

A retrospective review of 53 patients with STS of the hand who were treated between 1996 and 2005 was performed. Recurrence‐free survival (RFS) and functional outcome of hand‐preserving procedures were assessed according to the Musculoskeletal Tumor Society (MSTS) system.

RESULTS:

The median RFS was not reached at the time of last follow‐up. Of 53 patients, 6 (11%) had positive microscopic resection margins. Three patients underwent repeat resection to negative surgical margins, whereas another 3 patients did not. All 3 patients with positive microscopic surgical margins that were not re‐excised developed local disease recurrence; 2 patients also developed distant metastases. Two of the 50 patients with negative resection margins developed distant metastases. All 5 patients who developed local and/or distant disease recurrence had deep tumors. The median MSTS score was 29 (interquartile range, 27‐30). Patients who underwent more extensive resections, such as double ray amputations, had lower MSTS scores.

CONCLUSIONS:

Suboptimal biopsies and positive resection margins are associated with local and distant disease recurrence in patients with STS. The results of the current study suggest that aggressive surgical treatment can result in better clinical outcomes, and underscore that care must be taken when planning biopsies of hand tumors. Cancer 2011. © 2010 American Cancer Society.
e‐Science Central for CARMEN: science as a service
Authors: Watson Paul , Hiden Hugo , Woodman Simon
Published: August 2010

Scientists face many severe challenges in extracting value from the increasingly large volumes of data they generate. In this paper we describe the requirements we have derived from working across a wide range of e‐science projects. In particular, the CARMEN neuroinformatics project has exposed a range of challenges due to a need to analyse and share large volumes of data. We have identified the four key activities required by scientists with whom we work, and designed an integrated system—e‐Science Central—to provide them. This exploits three emerging technologies: software as a service to avoid the need for users to deploy and maintain any of their own software; social networking to allow users to collaborate by sharing data, services and workflows in a controlled manner and Cloud computing to provide scalable compute resources. The system can not only be used through any web browser, but also provides an API so that applications can build on the core functionality. We describe the requirements, and the design that flows from them. This includes data storage with in‐built versioning and signing, an in‐browser workflow editor and a job scheduling system that allows workflows to be run both on local ‘private’ clouds and the Microsoft Azure Cloud. Copyright © 2010 John Wiley & Sons, Ltd.
The scalable process topology interface of MPI 2.2
Authors: Hoefler Torsten , Rabenseifner Rolf , Ritzdorf Hubert , de Supinski Bronis R. , Thakur Rajeev , Träff Jesper Larsson
Published: August 2010

The Message‐passing Interface (MPI) standard provides basic means for adaptations of the mapping of MPI process ranks to processing elements to better match the communication characteristics of applications to the capabilities of the underlying systems. The MPI process topology mechanism enables the MPI implementation to rerank processes by creating a new communicator that reflects user‐supplied information about the application communication pattern. With the newly released MPI 2.2 version of the MPI standard, the process topology mechanism has been enhanced with new interfaces for scalable and informative user‐specification of communication patterns. Applications with relatively static communication patterns are encouraged to take advantage of the mechanism whenever convenient by specifying their communication pattern to the MPI library. Reference implementations of the new mechanism can be expected to be readily available (and come at essentially no cost), but non‐trivial implementations pose challenging problems for the MPI implementer. This paper is first and foremost addressed to application programmers wanting to use the new process topology interfaces. It explains the use and the motivation for the enhanced interfaces and the advantages gained even with a straightforward implementation. For the MPI implementer, the paper summarizes the main issues in the efficient implementation of the interface and explains the optimization problems that need to be (approximately) solved by a good MPI library. Copyright © 2010 John Wiley & Sons, Ltd.
On the Origin of the Visible‐Light Activity of Titanium Dioxide Doped with Carbonate Species
Authors: Tian FengHui , Liu ChengBu , Zhang Dongju , Fu Aiping , Duan Yunbo , Yuan Shuping , Yu Jimmy C.
Published: August 2010

Plane‐wave‐based pseudopotential density functional theory (DFT) calculations are used to elucidate the origin of the high photocatalytic efficiency of carbonate‐doped TiO2. Two geometrically possible doping positions are considered, including interstitial and substitutional carbon atoms on Ti sites. From the optical absorption properties calculations, we believe that the formation of carbonates after doping with interstitial carbon atoms is crucial, whereas the contribution from the cationic doping on Ti sites is negligible. The carbonate species doped TiO2 exhibits excellent absorption in the visible‐light region of 400–800 nm, in good agreement with experimental observations. Electronic structure analysis shows that the carbonate species introduce an impurity state from Ti 3d below the conduction band. Excitations from the impurity state to the conduction band may be responsible for the high visible‐light activity of the carbon doped TiO2 materials.
What is narrative therapy and what is it not? The usefulness of Q methodology to explore accounts of White and Epston's (1990) approach to narrative therapy
Authors: Wallis Jennifer , Burns Jan , Capdevila Rose
Published: August 2010

Objective. ‘What is narrative therapy and how do you do it?’ is a question that is repeatedly asked of narrative therapy, with little consistent response. This study aimed to explore and distil out the ‘common themes’ of practitioner definitions of White and Epston's approach to narrative therapy.

Design. This was an Internet‐based study involving current UK practitioners of this type of narrative therapy using a unique combination of a Delphi Panel and Q methodology.

Method. A group of experienced practitioners were recruited into the Delphi Poll and were asked two questions about what narrative therapy is and is not, and what techniques are and are not employed. These data combined with other information formed the statements of a Q‐sort that was then administered to a wider range of narrative practitioners.

Findings. The Delphi Panel agreed on a number of key points relating to the theory, politics and practice of narrative therapy. The Q‐sort produced eight distinct accounts of narrative therapy and a number of dimensions along which these different positions could be distinguished. These included narrative therapy as a political stance and integration with other approaches.

Conclusions. For any therapeutic model to demonstrate its efficacy and attract proponents, an accepted definition of its components and practice should preferably be established. This study has provided some data for the UK application of White and Epston's narrative therapy, which may then assist in forming a firmer base for further research and practice. Copyright © 2010 John Wiley & Sons, Ltd.

Key Practitioner Message:

• Narrative therapy and how it is carried out remain unclearly defined, which limits studies of the efficacy of this approach.

• Experienced practitioners of narrative therapy were able to identify a set of core concepts, values and techniques over which there was some consensus.

• This study also identified the different ‘positionings’ of narrative therapy that have contributed to its opacity and have highlighted the diversity in therapist practice.
Separation of glucose and fructose by freezing crystallization
Authors: Silva A. T. C. R. , Martinez K. C. L. , Brito A. B. N. , Giulietti M.
Published: August 2010

This work comprises the implementation of a methodology for the study of an industrial crystallization process by freezing and cooling to be applied in the separation of sugars with industrial relevance (glucose and fructose). The main interest is the production of fructose. This sugar is obtained by sucrose hydrolysis in acidic solutions, which yields an equimolar mixture of glucose and fructose. The developed separation process is based on the solubility difference between the sugars. Experiments were carried out in a jacketed glass crystallizer where the solution coming from the sucrose acid inversion was submitted to a slow cooling. Since glucose has lower solubility than fructose, it crystallizes in the bulk as the temperature is lowered, thus it can be removed from the solution by fliltration or centrifugation. Best fructose‐glucose separation was achieved for a total sugar concentration of 50 wt%. (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Influence of period‐doubling bifurcations in the appearance of border collisions for a ZAD‐strategy‐controlled buck converter
Authors: D'Amico M. B. , Angulo F. , Olivar G. , Paolini E. E. , Moiola J. L.
Published: August 2010

The first period‐doubling bifurcation of a dc–dc buck converter controlled by a zero‐average dynamic strategy is studied in detail. Owing to the saturation of the duty cycle, this bifurcation is followed by a border‐collision bifurcation, which is the main mechanism to introduce instability and chaos in the circuit. The multiparameter analysis presented here leads to a complete knowledge of the relatioship between these two bifurcations. The results are obtained by using a frequency‐domain approach for the study of period‐two oscillations in maps. Copyright © 2010 John Wiley & Sons, Ltd.
Mass Analysis of Growth of Al2O3 Thin Films from Low‐Temperature Atomic Layer Deposition on Woven Cotton
Authors: Hojo Daisuke , Adschiri Tadafumi
Published: August 2010

Atomic layer deposition (ALD) at 100 °C provides a conformal coating on woven cotton with a tortuous and complex surfaces. The woven structures are completely preserved and replicated with thin coating of Al2O3, even after removing the cotton templates. The replicated woven structures enable direct mass analysis of the cotton coating. Quantitative analysis reveals that the self‐limiting reaction of ALD is ensured, even on tortuous cotton surfaces, except for early growth cycles. This unique feature of ALD assures conformal coating onto three‐dimensional (3D) networks of cotton. The results demonstrate the possibility of a non‐local methodology for evaluating the thickness of a coating on 3D objects at various stages of growth.
An irregular frequency reuse scheme for cellular OFDMA systems
Authors: Rim Minjoong
Published: August 2010

While conventional frequency reuse techniques need to allocate mutually exclusive frequency resources to adjacent cells, this paper proposes a technique for OFDMA systems to use pseudo‐random subchannel allocation patterns based on the preamble number. Although sophisticated cell planning is not required for the proposed technique, irregular frequency patterns can allow efficient interference avoidance and high data throughput. Copyright © 2010 John Wiley & Sons, Ltd.
Zirconocene Functional Group Chemistry: Photochemical [4+4] Cycloaddition of Isoprenyl Sidechains to the Bent Metallocene Framework
Authors: Greger Ingo , Kehr Gerald , Erker Gerhard
Published: August 2010

The 4‐isoprenyl‐ and 1‐isoprenylcyclopentadienides 6a and 6b were prepared by means of a fulvene route involving a subsequent deprotonation reaction using potassium hexamethyldisilylamide. Transmetallation to zirconium or hafnium gave the respective bis(4‐isoprenyl‐Cp)MCl2 and bis(1‐isoprenyl‐Cp)MCl2 complexes 7a,b and 8a,b, respectively. Upon photolysis, the (4‐isoprenyl‐Cp)2ZrCl2 and ‐HfCl2 complexes 7a, 8a underwent rapid intramolecular [4+4] cycloaddition reactions to yield the cyclooctadienylene‐bridged ansa‐metallocenes 9a, 10a in high yields.
Various Synthetic Methods for One‐Dimensional Semiconductor Nanowires/Nanorods and Their Applications in Photovoltaic Devices
Authors: Chun Jinyoung , Lee Jinwoo
Published: August 2010

In this microreview, the recent progress on various synthetic methods for 1D semiconductor nanowires is summarized. The colloidal synthetic method has been popularly employed to prepare various semiconductor nanorods/nanowires such as ZnS and TiO2. The vapor–liquid–solid (VLS) synthetic method has been used to fabricate Si and ZnO nanowires. For the growth of semiconductor nanowires by the VLS method, metals that can form a eutectic mixture with a target material have been used as catalysts. After the first report on the synthesis of crystalline III–V semiconductor nanowires by the solution–liquid–solid (SLS) method, various kinds ofIII–V and II–VI semiconductor nanowires have been synthesized by the SLS method. Various types of templates, including anodic aluminum oxide (AAO), sacrificial nanowire templates, and self‐assembled surfactants, have been employed to fabricate 1D semiconductor nanowires that resemble the shape of the template employed. Using 1D semiconductor nanowires, high‐performance photovoltaic cells can be fabricated due to facile electron transport within nanowires.
Design of a Vitamin B1‐Selective Electrode Based on an Ion‐Pair and Its Application to Pharmaceutical Analysis
Authors: Antal Iryna , Kormosh Zholt , Bazel Yaroslav , Lysenko Svitlana , Kormosh Natalya
Published: August 2010

Vitamin B1‐selective electrodes with PVC membrane were developed that contain ion associates of vitamin B1 with an inorganic anion, BiI4−, and an organic anion, brilliant yellow, as electrode‐active substances. The linearity ranges of the electrode function are 1.0×10−5–1.0×10−2 and 1.0×10−4–1.0×10−2 M, the electrode function slopes are 33.0±1.0 and 33.1±1.1 mV decade−1, the detection limits are 5.5×10−6 and 8.3×10−5 M for BiI4− and brilliant yellow respectively. The working range of pH is 5–12. The efficiency of the use of electrodes for the vitamin B1 content control in multivitamin pharmaceutical preparations was shown by direct potentiometry and potentiometric titration methods.
Electroanalysis of Norepinephrine at Bare Gold Electrode Pure and Modified with Gold Nanoparticles and S‐Functionalized Self‐Assembled Layers in Aqueous Solution. Part II
Authors: Łuczak Teresa
Published: August 2010

Gold electrodes modified with S‐containing compounds and gold were used for determination of norepinephrine (NEP) in aqueous solution. A linear relationship between norepinephrine concentration and current response was obtained in the range of 0.1 µM to 600 µM with the detection limit ≤0.090 µM for the electrodes modified at 2D template and in the range of 0.1 µM to 700 µM with the detection limit ≤0.075 µM for the electrodes modified at 3D template. The results have shown that modified electrodes could clearly resolve the oxidation peaks of norepinephrine, ascorbic (AA) and uric acid (UA) with peak‐to‐peak separation enabling determination of NEP, AA and UA in the presence of each other.
Electrochemical Behavior of Herbal Antitumor Drug Aloe‐Emodin at Carbon‐Coated Nickel Magnetic Nanoparticles Modified Glassy Carbon Electrode
Authors: Bian Chunli , Zhang Lin , Xiong Huayu , Zhang Xiuhua , Wang Shengfu
Published: August 2010

The electrochemical behavior of aloe‐emodin (AE), an important herbal antitumor drug, was investigated at a carbon‐coated nickel magnetic nanoparticles modified glassy carbon electrode (CNN/GCE). A couple of well‐defined redox peaks was obtained. Some electrochemical parameters of AE at a CNN/GCE, such as the charge number, exchange current density, standard heterogeneous rate constant, were measured. The square wave voltammetry (SWV) response of AE was linear with the concentration over two concentration intervals viz. 6.24×10−9−1.13×10−6 M and 1.13×10−6−1.23×10−5 M, with a detection limit of 2.08 nM. A fast, simple and sensitive detection and analysis of AE was developed.
Quantification of Quercetin Using Glassy Carbon Electrodes Modified with Multiwalled Carbon Nanotubes Dispersed in Polyethylenimine and Polyacrylic Acid
Authors: Gutiérrez Fabiana , Ortega Gabriela , Cabrera José Luis , Rubianes María D. , Rivas Gustavo A.
Published: August 2010

This work reports the highly sensitive detection of quercetin using glassy carbon electrodes modified with multiwall carbon nanotubes (MWCNT) dispersed in polyethylenimine and poly(acrylic acid). The adsorptive stripping with square wave voltammetric transduction allowed the detection of 7.5 nM quercetin after 1.0 min accumulation at open circuit potential. The amperometric detection at 0.150 V is reported as an easier and simpler alternative to determine quercetin, with detection limits of 0.2 µM. The careful selection of the working conditions also made possible the detection of submicromolar levels of quercetin in the presence of excess of rutin. The proposed methodology was successfully used to quantify quercetin in onion samples.
Polystyrene spheres coated with gold nanoparticles for detection of DNA
Authors: Li Shaohua , Xia Yuetong , Zhang Jianping , Han Jianhua , Jiang Long
Published: August 2010

A novel method has been developed here utilizing gold‐modified polystyrene spheres (PS@Au) as carriers for the investigation of DNA hybridization. The immobilization ability of DNA probes on the PS@Au was investigated by a quartz crystal microbalance (QCM). More gold nanoparticles (AuNPs) were conjugated to the QCM surface in the form of PS@Au as compared with the AuNPs alone. The influence of PS, AuNPs population and size on the DNA probe fixation, and hybridization has been investigated. The results show that more AuNPs were achievable onto the QCM surface and could greatly increase the immobilization amount further hybridization amount of DNA. There was an optimal surface curvature for the probe DNA absorption. The curvature about 12 nm was more suited to the adsorption of probe DNA which could lead to the detection limit further down to 10−12 M. These results demonstrate that the introduction of PS@Au, with polystyrene spheres as the medium between the QCM surface and the AuNPs, could achieve modified QCM surfaces and increase its detection ability for a better DNA assay and a novel platform for the fabrication of DNA sensors.
Application of Sharpless asymmetric epoxidation on the preparation of the optically active flavours 3‐methylthiohexanal and 5(6)‐butyl‐1,4‐dioxan‐2‐one
Authors: Tian Hong‐yu , Sun Bao‐guo , Tang Li‐wei , Ye Hong‐lin
Published: August 2010

Optically active 2,3‐epoxyhexanol obtained from Sharpless asymmetric epoxidation (AE) was regioselectively reduced to 1,3‐hexandiol or 1,2‐hexandiol. 1,3‐Hexandiol was converted to 3‐mesyloxyhexyl acetate. The following reaction with CH3SK gave 3‐methylthiohexanol, which was oxidized through Swern oxidation to produce 3‐methylthiohexanal. 5‐ and 6‐Butyl‐1,4‐dioxan‐2‐one were formed concurrently by the reaction of 1,2‐hexandiol with 2‐bromoacetic chloride and the ratio of 5‐butyl isomer to 6‐butyl isomer was about 1:4. The enantiomeric excess values of both enantiomers of 3‐methylthiohexanal and 5(6)‐butyl‐1,4‐dioxan‐2‐one were about 90%, which were very close to those of 2,3‐epoxyhexanol (about 94% ee). No obvious racemization occurred during the transformation from the Sharpless AE products to the final products.
Identification of the causes of an allergic reaction to a fragranced consumer product
Authors: Cadby Peter , Ellis Graham , Hall Barbara , Surot Carol , Vey Matthias
Published: August 2010

Identification of substances in consumer products (more particularly fragrance allergens in cosmetics) that are responsible for cases of contact dermatitis is of key importance for the patient and also for industry so that appropriate risk management measures can be applied. This is best done by a close collaboration between the dermatologist, the manufacturer of the consumer (cosmetic) product and the fragrance supplier. This paper describes a recommended practice that has been successfully applied for many years to achieve this goal. Copyright © 2010 John Wiley & Sons, Ltd.
Identification of a functional hepatocyte nuclear factor 4 binding site in the neutral ceramidase promoter
Authors: Maltesen Henrik R. , Troelsen Jesper T. , Olsen Jørgen
Published: August 2010

The brush border membrane of the differentiated small intestinal epithelial cell is studded with membrane bound hydrolytic ectoenzymes involved in digestion. Previous studies of the regulation of genes encoding brush border enzymes have especially implicated the transcription factors hepatocyte nuclear factor HNF‐1 and Cdx2. Recent genome‐wide studies have, however, also identified HNF‐4α as a transcription factor with a high number of target genes in the differentiated small intestinal epithelial cell. The Asah2 gene encodes neutral ceramidase, which is a hydrolytic brush border enzyme involved in ceramide digestion. It was the purpose of the present work to experimentally verify the functional importance of a HNF‐4α binding site predicted by bioinformatic analysis to be present in the Asah2 promoter. Using supershift analysis, HNF‐4α overexpression, and HNF‐4α knockdown experiments it was confirmed that the predicted HNF‐4α binding site identified in the Asah2 promoter is functional. The results support the hypothesis that HNF‐4α might be important for intestinal glycolipid metabolism. J. Cell. Biochem. 111: 1330–1336, 2010. © 2010 Wiley‐Liss, Inc.
AAV plasmid DNA simplifies liver‐directed in vivo gene therapy: comparison of expression levels after plasmid DNA‐, adeno‐associated virus‐ and adenovirus‐mediated liver transfection
Authors: Doenecke Axel , Krömer Alexander , Scherer Marcus N. , Schlitt Hans‐Jürgen , Geissler Edward K.
Published: August 2010

Background

Successful liver gene therapy depends on efficient gene transfer techniques and long‐lasting gene expression after successful transfer. Over the last decades, important progress has been made with the introduction of viral vectors using animal models, although their use is hampered by a complex and costly preparation compared to the simple and cost‐effective preparation of plasmid DNA. These problems become even more critical when considering the application of viral vectors in human gene therapy and gene therapy trials. In a previous study, we were able to show that the hydrodynamics‐based gene transfer of plasmid‐DNA, containing the adeno‐associated‐virus specific inverted terminal repeats (AAV‐ITR), prolongs gene expression in the liver, although it remained unclear whether plasmid gene transfer could achieve similar expression levels compared to viral‐vector gene transfer.

Methods

Rat livers were transfected in‐vivo with AAV‐ITR‐containing plasmid‐DNA using a modified hydrodynamics‐based procedure. Expression levels were monitored thereafter and compared with expression levels after viral‐vector gene transfer.

Results

A high and stable long‐term expression was achieved after in vivo transfection of rat livers with AAV‐ITR‐containing plasmids. The expression course resembled that after AAV‐mediated gene transfer, and the expression was at least as high, and lasted as long, compared to recombinant AAV‐mediated gene transfer.

Conclusions

We consider AAV‐ITR‐containing plasmids as a simple and cost‐effective alternative to recombinant viral vectors, especially for liver‐directed gene therapy in rodents. With ongoing progress in gene transfer methods for naked DNA, these plasmids may also become a successful alternative to recombinant viral vectors in human gene therapy. Copyright © 2010 John Wiley & Sons, Ltd.
Reaction of 3‐iodoindole with 1,4‐naphthoquinones
Authors: Tanoue Yasuhiro , Teraoka Takashi , Kai Norihisa , Nagai Takeshi , Ushio Kazutoshi
Published: August 2010

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The usefulness of 3‐iodoindole available for introduction of an indole unit is presented. The reaction of 3‐iodoindole with 2‐bromo(or methyl)‐1,4‐naphthoquinone in acetic acid gave 2‐bromo(or methyl)‐3‐(3‐indolyl)‐1,4‐naphthoquinone. On the other hand, the reaction of 3‐iodoindole with 2‐bromo‐1,4‐naphthoquinone in the presence of cesium carbonate in acetonitrile produced 2‐(1‐indolyl‐3‐iodo)‐1,4‐naphthoquinone. J. Heterocyclic Chem., (2010).
Synthesis of (±)‐trans‐hexahydropyrrolo[3,4‐d]oxazol‐2‐one and its derivatives by using N‐(tert‐butyloxycarbonyl)‐3‐pyrroline as precursor
Authors: Rajesh Tammana , Rao Sambangi Polinaini Narayana , Suresh Kopparthi , Madhusudhan Gutta , Mukkanti Kagga
Published: August 2010

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Synthetic method for the preparation of (±)‐trans‐hexahydropyrrolo[3,4‐d]oxazol‐2‐one and its derivatives has been developed. By one route, an efficient preparation of these fused heterobicyclic moieties could be achieved, which are prepared by using N‐(tert‐butyloxycarbonyl)‐3‐pyrroline as precursor. These fused heterobicyclic systems could be useful to develop a series of 2‐oxazolidinone analogues. J. Heterocyclic Chem., (2010).