bluuebunny/crossref_metadata_2025 huggingface dataset:
Enhancing News Articles: Automatic SEO Linked Data Injection for Semantic Web Integration
Authors: Salem Hamza , Salloum Hadi , Sabbagh Kamil , Mazzara Manuel
Published: November 2024

This paper presents a novel solution aimed at enhancing news web pages for seamless integration into the Semantic Web. By utilizing advanced pattern mining techniques alongside OpenAI’s GPT-3, we rewrite news articles to improve their readability and accessibility for Google News aggregators. Our approach is characterized by its methodological rigor and is evaluated through quantitative metrics, validated using Google’s Rich Results Test, which confirms the effectiveness of our generated structured data. The impact of our work is threefold: it advances the technological integration of a substantial segment of the web into the Semantic Web, promotes the adoption of Semantic Web technologies within the news sector, and significantly enhances the discoverability of news articles in aggregator platforms. Furthermore, our solution facilitates the broader dissemination of news content to diverse audiences. This submission introduces an innovative solution substantiated by empirical evidence of its impact and methodological soundness, thereby making a significant contribution to the field of Semantic Web research, particularly in the context of news and media articles.
Smoking and Risk of Fatty Liver Disease: A Meta-Analysis of Cohort Studies
Authors: Lee Moonhyung , Myung Seung-Kwon , Lee Sang Hee , Chang Yoosoo
Published: November 2024

It remains inconclusive whether smoking is associated with an increased risk of fatty liver dis-ease (FLD). We investigated the association between smoking and the risk of FLD by using a meta-analysis of cohort studies. PubMed and EMBASE were searched using keywords from in-ception to September 2023 to identify relevant studies. Out of 806 articles searched from data-bases, a total of 20 cohort studies were included in the final analysis. In the meta-analysis, smoking was significantly associated with an increased risk of FLD (odds ratio/relative risk/hazard ratio, 1.14; 95% confidence interval, 1.05 – 1.24; n = 20). Subgroup analyses showed a significant positive association between them in prospective cohort studies (odds ratio/relative risk/hazard ratio, 1.15; 95% confidence interval, 1.05 – 1.18; n = 5), but not in retrospective cohort studies and cross-sectional studies based on cohort studies. In the subgroup meta-analysis by gender in Asians, smoking significantly increased the risk of FLD in men, while there was no significant association between them in women. This meta-analysis showed that smoking in-creases the risk of FLD. In addition to well-known risk factors of FLD such as obesity and alcohol consumption, clinicians should recommend smoking cessation for the management of FLD.
Design, Synthesis and Antiproliferative Evaluation of Glucose 6ʺ-OH Modified Open-Chain Analogues of Ipomoeassin F
Authors: Khosravi Arman , Nnamdi Precious , May Alexa , Slattery Kelsey , Sammelson Robert E. , Shi Wei Q.
Published: November 2024

Ipomoeassin F (Ipom-F) is a plant-derived macrocyclic resin glycoside that potently inhibits cancer cell growth through blockage of Sec61-mediated protein translocation at the endoplasmic reticulum. Recently, detailed structural information on how Ipom-F binds to Sec61α was obtained using Cryo-EM, which discovered that polar interactions between asparagine-300 (N300) in Sec61α and four oxygens in Ipom-F are crucial. One of the four oxygens is from the carbonyl group at C-4 of the fatty caid chain. In contrast, our previous structure–activity relationship (SAR) studies suggest that the carbonyl group is not essential. To resolve this discrepancy, we designed and synthesized two new open-chain analogues (10 and 11). 10 without the C-4 carbonyl had a dramatic activity loss, whereas 11 with an amide functional group was even more potent than Ipom-F. These new SAR data, in conjunction with some previous SAR information, imply two functional roles of the C-4 carbonyl: 1) to form H-bonds with N300; and 2) to regulate interactions of the fatty acid chain with membrane lipids. Impacts of these dual functions on antiproliferation depend on the overall structure of an Ipom-F derivative. Moreover, 11 can serve as a lead compound for developing future amino acid/peptide-modified analogues of Ipom-F with improved therapeutic properties.
Association Between Physical Fitness and Cardiovascular Health in Chilean Schoolchildren from the Metropolitan Region
Authors: Vásquez Fabián , Salazar Gabriela , Vasquez Sofia , Torres Jorge
Published: November 2024

Background: Cardiovascular diseases increasingly impact youth, with early development of risk factors such as obesity, hypertension, and inadequate nutrient intake. Proper nutrient intake and physical fitness are vital for reducing these risks, especially in pediatric populations. This study explores the connection between physical fitness, metabolic risk, and nutrient status among 1656 Chilean schoolchildren from diverse so-cio-economic backgrounds. Methods: Anthropometric measures included weight, height, skinfold thickness, waist circumference, and blood pressure. Physical fitness was assessed via handgrip strength, standing long jump, and a six-minute walk test. Nutrient intake was also evaluated, and a composite metabolic risk score was calculated based on waist circumference, skinfolds, and blood pressure. Results: Children from public schools exhibited higher obesity rates and waist circumferences than those from private schools. Physical fitness performance was strongly linked to cardiovascular health indicators: better fitness correlated with smaller waist circumferences, lower skinfold measurements, and healthier blood pressure levels. Children from private schools had better fitness test outcomes, indicating socio-economic disparities in access to physical activity and nutrient resources. Students with lower fitness and nutrient intake had higher metabolic risk scores, pointing to increased cardiovascular risk. Conclusions: Nutrient intake and physical fitness are essential to reducing cardiovascular risk in children. Significant differences in nutrient intake and fitness levels across socio-economic lines suggest that equal access to nutrition and physical activity programs in schools could benefit public health outcomes. Further research should investigate the lasting effects of nutri-ent-focused interventions on childhood metabolic health.
A Simplified Integrative Approach to Assessing Productive Sustainability and Livelihoods in the “Amazonian Chakra” in Ecuador
Authors: Torres Bolier , Luna Marcelo , Tipán-Torres Cristhian , Ramírez Patricia , Muñoz Julio C. , García Antón
Published: November 2024

This study combines two methodologies—key indicators from the Sustainable Livelihoods Framework (SLF) and the Sustainability Assessment of Food and Agriculture Systems (SAFA) approach—to evaluate sustainability among 330 producers from three associations working within the recently recognized Amazonian Chakra system, designated as a Globally Important Agricultural Heritage System (GIAHS). The SAFA framework's four dimensions—Good Governance, Environmental Integrity, Economic Resilience, and Social Well-being—were used to assess sustainability, while the SLF considered key capitals such as financial, natural, and human capitals as critical for understanding livelihood outcomes. The discriminant analysis revealed significant differences across the associations, with Kallari and Wiñak performing better in financial management, environmental practices, and governance compared to Tsatsayaku, which exhibited weaker outcomes in these domains. Key indicators such as chakra income, price determination, and civic responsibility were the most effective in distinguishing the groups. The income analysis further highlights that Tsatsayaku reported the highest total income but relies heavily on non-Chakra sources, while Kallari and Wiñak showed stronger reliance on Chakra income, which aligns with their more sustainable agricultural practices. Per-capita income was higher for Tsatsayaku, but extreme poverty levels remained similar across all associations, underscoring the need for targeted financial interventions. Policy recommendations include promoting access to financial resources and strengthening participatory governance models to enhance sustainability outcomes across associations. For future research, combining the SAFA and SLF provides a comprehensive and robust methodology for assessing sustainability in agricultural systems, enabling a deeper understanding of the interactions between social, economic, and environmental factors in diverse contexts.
Synthesis of a Novel Polymer Adsorbent TOC and Its Adsorption of Pb (II) and Cu (II) Ions in Water
Authors: Chen Dun , Zhou Wanyong
Published: November 2024

This article successfully synthesized a polymer adsorbent TOC containing S functional groups through thiophene and ethanedioyl chloride. The TOC was characterized by IR, molecular weight determination, EDS, SEM, and TG. For Pb(II), the maximum adsorption capacity of TOC can reach 122.7 mg/g (0.593 mmol/g) at pH=4, 250 minutes. After adsorption, it can be desorbed with 1.00 mol/L HCl, and the adsorbent can be reused 10 times; For Cu(II), the maximum adsorption capacity of TOC can reach 95.9mg/g (1.498mmol/g) at pH=6, 180min. After adsorption, it can be desorbed with 0.50 mol/L HNO3, and the adsorbent can be reused 11 times. The adsorption process of TOC on Pb(II) and Cu(II) conforms to the Freundlich model of multi-layer adsorption and the chemical adsorption process controlled by pseudo-second-order kinetic reactions.
Oral Vaccine Formulation for Immunocastration Using a live-Attenuated Salmonella ΔSPI2 Strain as an Antigenic Vector
Authors: Bucarey Sergio A. , Maldonado Lucy D. , Duarte Franciscof , Hidalgo Alejandro A. , Saénz Leonardo
Published: November 2024

The immunization against Gonadotropin-Releasing Hormone (GnRH) has been successfully explored and developed for the parenteral inoculation of animals, aimed at controlling fertility, reducing male aggressiveness, and preventing boar taint. Although effective, these vaccines may cause adverse reactions at the injection site, including immunosuppression and inflammation, as well as involvement of laborious and time-consuming procedures. Oral vaccines represent an advancement in antigen delivery technology in the vaccine industry. In this study, a Salmonella enterica serovar Typhimurium (S. Typhimurium) mutant lacking the pathogenicity island 2 (S. Typhimurium ΔSPI2) was used as a vehicle and mucosal adjuvant to deliver two genetic con-structs, in an attempt to develop an oral immunological preparation against Gonadotropin hormone-releasing hormone (GnRH). S. Typhimurium ΔSPI2 was transformed to carry two plasmids containing a modified GnRH gene repeated in tandem (GnRXG/Q), one under eu-karyotic expression control (GnRX GQ_OptMamm_V3::GnRXG/Q) and another under prokar-yotic expression control (pJexpress::GnRXG/Q). Group of three male BALB/c mice were orally immunized and tvaccination boosted 30-days later. Oral administration of S. Typhimurium ΔSPI2transformed with both plasmids was effective in producing antibodies against GnRXG/Q, leading to a decrease in serum testosterone levels and testicular tissue atrophy, evidenced by a reduction in the transverse tubular diameter of the seminiferous tubules and a decrease in the number of layers of the seminiferous epithelium in the testes of the inoculated mice. These re-sults suggest that S. Typhimurium ΔSPI2can be used as a safe and simple system to produce an oral formulation against GnRH, and that Salmonella-mediated oral antigen delivery is a novel, yet effective, alternative to induce an immune response against GnRH in a murine model, war-ranting further research in other animal species.
Cytotoxic, Antioxidant, and Anti-genotoxic Properties of Combretastatin A4 in Human Peripheral Blood Mononuclear Cells: A Comprehensive In Vitro Study
Authors: Popović Petar , Pirković Andrea , Topalović Dijana , Živković Lada , Marković Milica , Spremo-Potparević Biljana
Published: November 2024

Despite significant progress in drug discovery and the promising antitumor potential of Combretastatin-A4 (CA-4) in selectively targeting rapidly dividing cancer cells, its effects on non-dividing human cells, such as peripheral blood mononuclear cells (PBMCs), remain unclear. This study aims to assess the in vitro bioactivity of CA-4 in human PBMCs, with a focus on its antigenotoxic and antioxidant properties, while comparing its cytotoxic potency against PBMCs, cancer cell lines (JAR and HeLa), and the normal trophoblast cell line HTR-8/SVneo. Cell viability and metabolic activity was assessed using MTT assay. ROS production in PBMCs was measured by H2DCFDA assay, and DNA damage was evaluated through comet assay. CA-4 exhibited cytotoxicity in PBMCs and HTR-8/SVneo cells at concentrations above 200 µM, while cancer cells, JAR and HeLa, demonstrated cytotoxicity at 100 µM and 1 µM, respectively. CA-4 also reduced ROS levels in PBMCs under oxidative stress, showing antioxidant effects across concentrations ranging from 1 to 200 µM. Additionally, CA-4 demonstrated antigenotoxic effects against H2O2-induced DNA damage in PBMCs at concentrations up to 1 µM. CA-4 exhibited lower cytotoxicity in human PBMCs compared to cancer cells, inhibited ROS production, and demonstrated antioxidant and antigenotoxic properties, offering insights into its potential therapeutic efficacy and safety.
An Unbiased Approach to Identify Cellular Reprogramming Inducible Enhancers
Authors: Klagkou Eleftheria , Valakos Dimitrios , Foutadakis Spyros , Polyzos Alexander , Papadopoulou Angeliki , Vatsellas Giannis , Thanos Dimitris
Published: November 2024

Cellular reprogramming of somatic cells towards induced pluripotency is a multistep stochastic process mediated by the transcription factors Oct4, Sox2, Klf4 and c-Myc (OSKM), which orchestrate global epigenetic and transcriptional changes. We performed a large-scale analysis of integrated ChIP-seq, ATAC-seq and RNA-seq data and revealed the spatiotemporal highly dynamic pattern of OSKM DNA binding during reprogramming. We found that OSKM show distinct temporal patterns of binding to different classes of pluripotency-related enhancers. Genes involved in reprogramming are regulated by the coordinated activity of multiple enhancers, which are sequentially bound by OSKM for strict transcriptional control. Based on these findings, we developed an unbiased approach to identify Reprogramming Inducible Enhancers (RIEs), constructed enhancer-traps and isolated cells undergoing reprogramming in real-time. We used a representative RIE taken from the Upp1 gene fused to GFP and isolated cells at different time points during reprogramming and found that they have unique developmental capacities as they are reprogrammed with high efficiency due to their distinct molecular signatures. In conclusion, our experiments have led to the development of an unbiased method to identify and isolate reprogrammable cells in real-time by exploiting the functional dynamics of OSKM, which can be used as efficient reprogramming biomarkers.
Genome-Wide Identification and Evolution-Profiling Analysis of TPS Gene Family in Camphora longepaniculata
Authors: Liu Xin , Zhang Minghu , Zhao Xin , Yang Li , Shen Mang , Feng Ruizhang , Wei Qin
Published: November 2024

Camphora longepaniculata is an important economic crop renowned for its rich volatile terpene compounds. Terpene synthases (TPS) are key enzymes in the biosynthesis of these compounds, playing significant roles in plant growth, development, and secondary metabolism. In this study, a total of 86 TPS genes were identified in Camphora longepaniculata, which were classified into five groups based on their evolutionary relationships. Analysis of cis-regulatory elements revealed associations between TPS genes and processes related to plant growth, development, and environmental stress responses. Gene Ontology (GO) enrichment analysis indicated that these TPS genes are predominantly linked to various enzymatic activities. Furthermore, analysis of duplication events revealed that tandem duplications (TD) and whole genome duplications (WGD) are major driving forces in the evolution of the TPS gene family. Notably, 18 TPS genes were found to be upregulated in high essential oil content varieties of Camphora longepaniculata. These findings lay a solid foundation for further exploration of the functions of TPS genes in Camphora longepaniculata.
Reconfigurable Polarimetric Photodetector Based on MoS2/PdSe2 Heterostructure with Charge-Trap Gate Stack
Authors: Huang Xin , Bai Qinghu , Guo Yang , Liang Qijie , Liu Tengzhang , Liao Wugang , Jin Aizi , Quan Baogang , Yang Haifang , Liu Baoli , Gu Changzhi
Published: November 2024

Besides the intensity and wavelength, the ability to analyze the optical polarization of the detected light can provide a new degree of freedom for numerous applications, such as object recognition, biomedical applications, environmental monitoring and remote sensing imaging. However, the conventional filter-integrated polarimetric sensing systems require complex optical components and complicated fabrication process, severely limiting its on-chip miniaturization and functionalities. Herein, the reconfigurable polarimetric photodetection with photovoltaic mode are developed based on a few-layer MoS2/PdSe2 heterostructure channel and a charge-trap structure composed of Al2O3/HfO2/Al2O3 (AHA) stacked dielectric. Because of the remarkable charge-trapping ability of carriers in AHA stack, the MoS2/PdSe2 channel exhibits a high program/erase current ratio of 105 and memory window exceeding 20 V. Moreover, photovoltaic mode of MoS2/PdSe2 Schottky diode can be operated and manipulable, resulting into high and distinct responsivities in the visible broadband. Interestingly, the linear polarization of device can be modulated under program/erase states, enabling the reconfigurable capability of linearly polarized photodetection. This study demonstrates a new prototype heterostructure-based photodetector with capability of both tunable responsivity and linear polarization, demonstrating great potential application toward reconfigurable photosensing and polarization-resolved imaging applications.
Modelling the Distribution of Atmospheric Pollutants in the Urban Environment
Authors: Naizabayeva Lyazat , Sembina Gulbakyt , Suleimenova Madina , Manapova Ainur
Published: November 2024

This paper presents a three-dimensional model of pollutant diffusion in the atmosphere. The model is based on the advection-diffusion equation taking into account pollution sources and decay processes of substances. The numerical solution of the equation is realized using the finite difference method on a three-dimensional grid. The model takes into account the spatial distribution of pollutant concentrations, the influence of wind and atmospheric diffusion. Key parameters include diffusion coefficient, wind speed components, intensity of pollution sources and decay coefficient of substances. Special attention is paid to the vertical distribution of pollutants, which allows for more accurate modeling of atmospheric processes. The presented model can be used to predict the spread of pollutants, assess the impact of different sources on air quality and develop strategies to reduce air pollution in urban and industrial areas.
Comparison of Machine Learning Techniques to Classify Dry Beans Using Computer Vision
Authors: Chinchilla Caravaca Jesús
Published: November 2024

This study explores the classification of seven registered dry bean species using a dataset of 13,611 grain samples characterized by 16 features, including both dimensional and shape measurements. The primary objective was to develop robust Machine Learning models to accurately identify species while addressing challenges related to class imbalance and feature redundancy. A series of classification algorithms, including Decision Trees (DT), Random Forests (RF), k-Nearest Neighbors (KNN), Support Vector Machines (SVM), and Multi-Layer Perceptrons (MLP), were applied to evaluate their performance under various data conditions. Notably, the MLP model exhibited superior performance due to its capacity to capture complex patterns in high-dimensional data, achieving the highest classification accuracy. Random Forest models showed resilience to class imbalance, though misclassifications between similar species highlighted the need for improved feature selection. The results indicate that effective feature engineering and careful model tuning are crucial for enhancing classification accuracy in agricultural applications. The study concludes that future work should aim to expand the dataset and explore advanced data augmentation techniques to further improve model robustness and applicability in food security contexts. All code to recapitulate the analysis is available along with documentation of pipeline usage at https://github.com/jesusch10/beans_classification.
The Impact of Shipping Connectivity on Environmental Quality, Financial Development, and Economic Growth in RCEP Countries
Authors: Alshiqi Sevdie , Bekteshi Xhelil , Jóźwik Bartosz , Altin Fatma Gul , Dogan Mesut , Petrossyants Tatyana
Published: November 2024

This study investigates the relationship between shipping connectivity, environmental quality, financial development, and economic growth among 14 countries in the Regional Comprehensive Economic Partnership (RCEP) from 2006 to 2019. Using panel-corrected standard error, Dynamic Seemingly Unrelated Regression, and Driscoll-Kraay estimation methods, the analysis reveals that shipping connectivity significantly contributes to financial development and economic growth, while also exerting a negative impact on environmental quality. These findings underscore the dual role of shipping connectivity in fostering economic prosperity and increasing environmental challenges, highlighting the trade-offs between growth and sustainability. The study also emphasizes that as trade between RCEP countries grows, driven in part by the removal of customs tariffs, shipping activities—and consequently environmental pollution—will likely increase. To achieve sustainable development in the maritime sector, policymakers must devise strategies that maximize economic benefits while mitigating environmental harm. These strategies include promoting environmentally friendly green ports, adopting low-carbon and advanced technologies, and strengthening policies to control emissions and marine pollution. Collaboration among shipping companies, local governments, and environmental organizations is also essential.
General Theory of Information: The Bridge to Mindful Machines
Authors: Mikkilineni Rao
Published: November 2024

General Theory of Information (GTI) offers a groundbreaking framework for designing "mindful machines" that bridge the divide between biological intelligence and digital automation. GTI reimagines traditional computing by introducing cognitive, autopoietic (self-regulating) capabilities in digital systems, enabling them to perceive, adapt, and respond autonomously to changing conditions. Unlike conventional AI and AGI models that operate within predefined algorithmic constraints, GTI-based systems go beyond by incorporating self-awareness and a resilient digital "self," capable of storing interaction histories and learning from them. This paper explores GTI’s practical applications in systems requiring resilience, cognition, and ethical safeguards. In video streaming and medical assistance, GTI-based digital genomes enable systems to function independently, actively self-correct, and conform to policy-driven ethical standards. These mindful machines embody unique traits rarely achieved with traditional AI: robust resilience through self-corrective mechanisms, adaptive learning from accumulated experiences, and alignment with ethical principles that govern system behavior. In demonstrating how GTI can cultivate resilience, autonomy, and ethical decision-making, this paper reveals GTI’s potential to empower digital automata with human-like adaptability and values. As such, GTI emerges as a bridge to a new generation of digital systems designed not merely to execute but to understand, adapt, and ethically engage within complex real-world environments.
Impact of a Structured Social Skills Training Programme on Adolescents and Young Adults with Asperger Syndrome
Authors: Zoccante Leonardo , Sabaini Sara , Rigotti Erika , Bonatti Sophia Marlene , Lintas Camilla , Zaffanello Marco
Published: November 2024

Background/Objectives: Asperger Syndrome (AS) is a neurodevelopmental disorder within the autism spectrum disorders (ASD). Difficulties in social and communication skills characterise it despite individuals typically having average intelligence and language development. Improving socialisation skills in individuals with ASD requires a tailored approach that addresses their specific needs and encompasses a range of targeted strategies. This study investigates the effectiveness of a structured social skills training programme for adolescents and young adults with AS; Methods: Patients diagnosed with AS, irrespective of gender, were consecutively recruited from an outpatient clinic. The programme consisted of activities within the Social Skills, Autonomy, and Awareness module, designed for adolescent and young adult groups, conducted fortnightly, with sessions lasting between 1.5 to 3 hours each over 17 months. The Vineland Adaptive Behaviour Scales (VABS) assessed adaptive behaviour at enrolment and upon intervention completion. Data were statistically analysed using SPSS version 22.0 for Windows (SPSS Inc., Chicago, IL). Statistical analysis included automatic clustering, employing the Bayesian Information Criterion (BIC) to determine the optimal number of clusters within the dataset. The Pearson Chi-square and Fisher's exact tests were applied to assess whether variable distributions among the clusters differed significantly; Results: Thirty-one individuals (77.4% female) with AS participated in the study, with a mean age of 20.1 years (SD 7.0). The TwoStep algorithm identified two distinct clusters. The mean age at enrolment was significantly higher in Cluster 1 (n. 8) than in Cluster 2 (n. 23; p = 0.005). Additionally, the mean enrolment score on the Vineland II socialisation scale was significantly higher in Cluster 1 (93.9; SD 5.7) compared to Cluster 2 (49.0, SD 18.2; p < 0.001). At follow-up, the mean scores for both Cluster 1 (104.6, SD 13.3) and Cluster 2 (57.8, SD 18.0) showed significant increases (p < 0.05), with over 50% of participants demonstrating improvement in social skills; Conclusions: This study highlights distinct profiles among individuals with AS, revealing a clear association between age and social skills development. The intervention effectively enhanced social skills in most participants, regardless of the age at which treatment commenced. For some individuals, alternative or enhanced treatment options may be considered to achieve optimal outcomes.
Smart City Ontology Framework for Urban Data Integration and Governance Applications
Authors: Kuai Xi , He Xiaolong , He Biao , Liu Yu , Zhao Zhigang , Guo Renzhong
Published: November 2024

The diverse, heterogeneous, and dynamic nature of urban data poses challenges for semantic integration and knowledge sharing in smart city applications. Traditional urban governance sectors often develop domain-specific data standards, which are insufficient for integrating and applying multi-source heterogeneous data. This article proposes the Smart City Ontology Framework (SMOF), leveraging ontology technology for semantic-level data sharing and interoperability across different industries. SMOF adopts a top-down integration strategy, harmonizing diverse data standards from IoT, BIM, and GIS into a cohesive structure. This research delineates the foundational components of SMOF, encompassing entities, relationships, properties, events, and rules, and outlines the methodology and principles underpinning its construction. We further develop a scalable, hierarchical classification system for entities, properties and relationships, adaptable for specific semantic applications. Through a fire emergency scenario, we exemplify SMOF's practical utility in knowledge representation and data mapping, highlighting its capacity for semantic querying within complex urban data ecosystems. Our findings indicate SMOF's significant role in fostering integrated urban data management, thereby enhancing data interoperability and applicability in diverse urban governance contexts.
Reevaluation of an Established In Vivo Gastric Vessel Bleed Model for Hemostatic Device Safety and Efficacy Testing
Authors: Grimsby Jessica Lynne , Szkolnicki Matthew David , Wood Kevin Andrew
Published: November 2024

For over a decade, endoscopic hemostatic powders have been used to manage upper gastrointestinal bleeding (UGIB). Various preclinical benchtop and animal models have been developed to evaluate these devices. Multiple companies have released hemostatic powders to market, assessing their safety and efficacy using an established porcine gastric vessel bleed model. This model simulates an aggressive arterial bleed, allowing prototypes to be tested under challenging conditions. It requires a surgeon to insert an artery segment into the gastric lumen and puncture it to produce a bleed. In our study, we tested a control group not included in prior research. We aimed to evaluate the relationship between intragastric pressure and bleed severity by injecting gas used to deliver hemostatic powder to the bleed site, without administering hemostatic powder. Our results indicate that elevated intragastric pressures alone can cause bleed cessation. Additional findings suggest that other factors in the model can lead to false positive hemostasis. This study highlights flaws in the porcine gastric vessel bleed model and underscores the need to develop more robust models for testing hemostatic devices, as no valid endoscopic bleed model currently exists. These experiments stress the importance of vetting preclinical models before acquiring efficacy data.
Power Quality Enhancement of Wind-Battery Supplied Standalone Microgrid by Using Super Twisting Sliding Mode Controllers
Authors: Sahbani Sana , Licer Oumnia , Mahmoudi Hassane , Hasnaoui Abdennebi , Kchikach Mustapha
Published: November 2024

There is a growing interest among researchers in the creation of innovative power supply systems that incorporate a range of generators, with a specific emphasis on renewable energy sources, especially wind energy. Battery-operated independent Microgrids powered by wind energy are increasingly recognized worldwide as a standalone power source for consumers. The power produced by the wind power conversion system depends on the wind speed, which can change quickly and without warning. It is essential to establish a robust energy management system accompanied by a responsive control approach to attain optimal energy balance and guarantee the delivery of high-quality power. In order to facilitate a rapid and efficient reaction to unexpected variations in the power supply system, the control strategy for the inverter and bidirectional DC to DC converter employs super twisting sliding mode controllers. The voltage at the DC link is controlled to maintain energy equilibrium within the standalone Microgrid, while a distinctive control approach for the three-phase inverter guarantees the delivery of high-quality power to AC loads. The proposed control methodologies in this paper employ super twisting sliding mode controllers to achieve rapid and effective responses during rapid changes in the system, whether on the generation or load side. The Hippopotamus optimization method is developed to obtain accurate values of various parameters used in super twisting sliding mode controllers under various operating conditions. The paper emphasizes the diverse outcomes and knowledge acquired through the execution of Hardware-in-the-Loop simulations utilizing the OPAL-RT platform. By employing this cutting-edge technology, researchers successfully tested and validated various hardware components within a simulated environment, facilitating a more efficient and cost-effective approach to analyzing and optimizing system performance. Further, detailed small signal analysis for the proposed methodology is also included in this paper.
Neuroplasticity and Mechanisms of Action of Acute and Chronic Treatment with Antidepressants at an Experimental Level
Authors: Rosas-Sánchez Gilberto Uriel , German-Ponciano León Jesús , Guillén-Ruiz Gabriel , Cueto-Escobedo Jonathan , Limón-Vázquez Ana Karen , Rodríguez-Landa Juan Francisco , Soria-Fregozo Cesar
Published: November 2024

The neurobiology of depression establishes a close relationship between this psychiatric disorder and alterations in neuroplasticity associated with neuronal atrophy and a reduction in dendritic arborization in the prefrontal cortex and hippocampus. In this sense, the therapeutic effect of antidepressants is associated with changes in the brain associated with neuroplasticity, neurogenesis and synaptogenesis through the activation of intracellular signaling pathways associated with changes at the neurochemical and behavioral level in animal models used to study depression. Antidepressants increase the synaptic availability of monoamines (monoaminergic hypothesis) such as serotonin, noradrenaline and GABA by inhibiting their reuptake or degradation and activating intracellular signaling pathways such as the cAMP-CREB cascade, which regulates the expression of genes related to neuroplasticity and neurogenesis in various brain structures associated with depression. Although acute treatment alters the number of receptors, the therapeutic effect lasts 3-4 weeks and depends on the increase in the density of dendritic spines and the expression of proteins such as BDNF and GAP-43 in the hippocampus and cerebral cortex. This review focuses on the effects of acute and chronic treatment with monoaminergic antidepressants and new drugs and other pharmacological alternatives in preclinical studies with the aim of demonstrating their mechanism of action and relationship to neuroplasticity.
Radial Artery Used as a Conduit for Coronary Artery Bypass Grafting
Authors: Nappi Francesco , Nassif Aubin , Schoell Thibaut , Acar Christophe
Published: November 2024

In 1989, we first reported the utilisation of the radial artery as a secondary conduit for coronary artery bypass grafting. However, subsequent randomised trials have reported discrepancies in clinical outcomes between the radial artery and alternative grafts. As we have now accumulated over 50 years of experience with radial artery grafting, we sought to identify the second-best target vessel for coronary operations by conducting a review of the literature. The radial artery has been demonstrated to be a consistently effective second target conduit for coronary artery bypass grafting. The results indicated improved outcomes and patency rates in comparison to those observed for saphenous vein grafts. Furthermore, it has been demonstrated to be a safe and effective conduit in the territory of the right coronary artery. The lack of available literature and the scarcity of similar case series restrict the application of the gastroepiploic artery. After five decades of utilisation, it can be unequivocally stated that the radial artery is the optimal conduit for coronary bypass surgery following the left internal thoracic artery to the left anterior descending artery.
A PECS II Block as Post Operative Analgesia After Modified Radical Mastectomy
Authors: Rosyadi Imron - , Anam Khairul , Mochamat Mochamat
Published: November 2024

Background: In Indonesia, breast cancer is the most common cancers in 2018, with a mortality rate of 11%. Postoperative pain is a complication that can occur after MRM surgery. The implementation of Enhanced Recovery After Surgery (ERAS) is currently increasingly being applied to breast surgery, one of which is by reducing the use of opioids. Selection of regional anesthetic technique as an alternative used in the form of neuraxial and peripheral nerve blocks. The use of regional anesthetic techniques also reduces the side effects of opioids that are often found, namely Post Operative Nausea and Vomiting (PONV) and pruritus. Analgesic technique with pectoral nerve block (PECS block) is an effective alternative postoperative MRM pain treatment in addition to opioid analgesia.

Methods: An analytical experimental study with double-blind randomized controlled trial (RCT) design. The study population was all patients who underwent MRM surgery at Dr. Kariadi General Hospital in May 2021 - August 2021. The study sample consisted of 46 subjects that obtained using the random allocation method, and randomly divided into two groups (PECS II block and control group). Postoperative pain scores, time to first request of rescue analgesic, total dose of rescue analgesic, incidence of PONV, and pruritus within 24 hours postoperative were analyzed in both groups.

Results: Based on the results of the analysis, the mean pain scores at 4, 12 and 24 hours postoperative were significantly lower in the PECS II block group compared to the control group (p=0.001, p=0.013, and p=0.003). The mean time to first use of rescue analgesics was longer and the total dose of rescue analgesics was lower in the PECS II block group (p=0.00, p=0.00). The incidence of PONV ((69,5 %) and postoperative pruritus (17,4 %) were more common in the control group (p=0.001, p=0.346)

Conclusion: PECS II block is effective as postoperative analgesic after modified radical mastectomy.
Effectiveness of Atropine Sulfate and Diazepam in Organophosphate Poisoning in Remote Area: A Case Report
Authors: Junapati I Kadek Ludi , Pratama Fabianus Anugrah
Published: November 2024

Background: Organophosphate poisoning is a significant public health concern in developing countries, including Indonesia, largely due to the widespread use of pesticides and insecticides. These chemicals, while effective for agricultural purposes, have been linked to severe health issues, including acute poisoning. One of the major health risks associated with organophosphate exposure is its potential link to suicide attempts. The toxic effects of organophosphates primarily stem from their inhibition of acetylcholinesterase, an enzyme crucial for the proper functioning of the nervous system. This inhibition leads to the accumulation of acetylcholine, resulting in overstimulation of the nervous system. Managing organophosphate poisoning poses a considerable challenge, particularly in remote areas where access to specific antidotes is limited.
 Case Illustration: A 17-year-old female high school student presented to the emergency room of the Boawae Primary Health Care Center with a major complaint of decreased consciousness, as evidenced by a Glasgow Coma Scale (GCS) score of 9/15. The patient had no prior history of neurological or psychiatric disorders. It was suspected that the patient had attempted suicide by ingesting pesticides approximately 60 minutes prior to admission. At the time of admission, she exhibited symptoms including nausea and vomiting, which had progressively worsened. Upon examination in the emergency room, the patient displayed increased saliva production and pinpoint pupils. In response to these symptoms, the medical team administered intravenous Diazepam and Atropine Sulfate, continuing treatment until atropinization was achieved.
 Conclusion:  In managing organophosphate poisoning, particularly in remote regions with limited access to specific antidotes, Atropine Sulfate and Diazepam represent viable alternative treatment modalities. These treatments can effectively counteract the toxic effects of organophosphates and achieve necessary atropinized conditions to stabilize the patient’s condition.
Internalisasi Nilai-Nilai Moderasi Beragama dalam Pembelajaran Al-Qur’an – Hadist di Pesantren
Authors: Hadiyanto Andy , Rohma Kubro  , Samitri Cendra
Published: November 2024

Islamic educational institutions, especially Pesantren, as one of the components of education, have a vital role as a responsible forum in efforts to reduce the development of radicalism. Lessons in Pesantren, especially the study of the Quran and hadith, require a paradigm shift that can bring Islamic scholarship so that it is not rigid in dealing with issues of radicalism. The study of the Quran and hadith in Pesantren that seems normative and past-oriented must now emerge by internalising the values of religious moderation as a solution to dealing with existing spiritual problems. Training has been held at Nurul Huda Setu Islamic Boarding School Bekasi, West Java, to internalise the values of religious moderation for teachers and educators as facilitators of understanding religious moderation through learning the Quran and hadith. This training is divided into two sessions, namely a theory session and a practical session. Theory sessions use lectures, discussions, and question-and-answer methods. At the same time, practical sessions are carried out through workshops. This training introduced iceberg analysis (iceberg analysis) and U process (U process) developed by Senge and Hamilton. The series includes event analysis, pattern of behavior analysis, and finally system structure examine. The series results can be followed up with the U process, which allows rethinking, redesigning, reframing and reacting.
Pendampingan Penerapan CHSE pada Pengelolaan Homestay Dusun Ciceuri Tengah di Desa Sukamandi Masagi
Authors: Ramadhani Alya , Brillian Prince  , Fedrina Rezka
Published: November 2024

Assistance in implementing CHSE for homestay managers in Sukamandi Masagi Village is certainly very important for the community. Sukamandi Masagi Village is a tourist village that is attractive to tourists for educational activities. This was seen when the village was used by Labschool Cirendeu students for live-in activities in 2022 and 2023 respectively. The need for insight and knowledge related to homestay management in accordance with CHSE standards so that homestay managers can know the standard criteria for a decent homestay. CHSE is a very important requirement in homestays because its application can increase security and safety for tourists. In this case, the goal is to increase knowledge and aspects of good and correct homestay management.
Program Penguatan dan Pendampingan Pemanfaatan Website Interaktif Alur Merdeka Pembelajaran Sekolah Dasar Untuk Guru – Guru Sekolah Dasar Mitra UPI Kampus Cibiru
Authors: Kurniawan Dede Trie , Abidin Yunus
Published: November 2024

Program pengabdian kepada masyarakat ini bertujuan sebagai upaya peningkatan kemampuan guru sekolah dasar mitra UPI Cibiru dalam memanfaatkan produk webiste interaktif alur MERDEKA hasil mahasiswa pascasarajana program studi S2 PGSD UPI Cibiru. Adapun produk pembelajaran yang telah dikembangkan adalah media dan bahan ajar terkini, strategi desain pembelajaran terintegrasi dengan teknologi webiste interaktif untuk pemenuhan keterampilan abad 21 siswa sekolah dasar. Secara rinci, tujuan pengabdian ini dapat diuraikan sebagai berikut : pertama memberikan pengetahuan kepada guru guru SD mengenai perkembangan implementasi kurikulum merdeka, kedua melatih keterampilan guru dalam mengelola pembelajaran dengan integrasi webiste interaktif alur MERDEKA, ketiga  melatih dan membimbing guru – guru SD dalam memanfaatkan media pembelajaran SD terkni dengan pemanfaatan teknologi informasi dan komunikasi. Metode yang digunakan dalam kegiatan pengabdian adalah workshop yang dilaksanakan selama bulan April hingga Juni 2024. Evaluasi kegiatan menggunakan model CIPP yang dikembangkan oleh Daniel Stuffleabem. Kegiatan pengabdian ini menargetkan khalayak sasaran adalah guru sekolah dasar mitra Kampus UPI Cibiru. Pada program pengabdian ini akan diselenggrakan kegiatan dengan ketentuan di beberapa wilayah difasilitasi dengan tatap maya, namun di beberapa wilayah akan dijalankan secara tatap muka. Secara garis besar dari kegiatan ini didapatkan respon postif dari peserta guru guru SD mitra UPI Cibiru. Mereka Berharap ada kegiatan Rutin dan terjadwal untuk pelatihan seperti ini agar terus bisa meningkatkan profesi profesional guru sesuai dengan perkembangan ilmu yang daidaptkan di perguruan tinggi.
Penyuluhan Desain Wisata Edukasi Ramah Anak di Desa Cisaat-Subang
Authors: Untailawan Tamaya Cethsa Gloria
Published: November 2024

Pengabdian masyarakat ini dilaksanakan di Desa Wisata Cisaat, Kecamatan Ciater, Kabupaten Subang, Jawa Barat dengan tujuan untuk mengembangkan paket wisata edukasi yang berbasis konsep ramah anak. Desa Wisata Cisaat sudah banyak dikunjungi wisatawan dari kalangan pelajar yaitu murid sekolah menengah pertama hingga sekolah menengah atas dengan program live-in. Sehingga diharapkan dari penelitian ini dapat menghasilkan paket wisata yang sesuai dengan konsep ramah anak dan membuka target pasar yang baru yaitu pelajar sekolah dasar dengan umur 5 hingga 12 tahun. Kegiatan ini menggunakan metorde studi literatur, observasi lapangan dan wawancara
Consensus Statement: Postoperative Management After Balloon Dilation of the Eustachian Tube
Authors: Kwak Min Young , Lee Ho Yun , Kong Soo-Keun , Moon In Seok , Kim Bong Jik , Suh Myung-Whan , Jung Jae Yun , Park Hong Ju , Lee Kyu-Yup , Cho Hyong-Ho , Ikeda Ryoukichi , Song Jae-Jin , Lee Chi-Kyou
Published: November 2024

Objectives. Balloon dilation of the Eustachian tube (BDET) is widely recognized as a minimally invasive treatment for obstructive Eustachian tube dysfunction (ETD). We employed a Delphi consensus methodology to develop recommendations for the clinical management of BDET in cases of obstructive ETD.Methods. A Delphi panel consisting of 26 expert physicians specializing in otology participated in two rounds of anonymous, iterative questionnaires. Consensus was defined as agreement from ≥70% of the panelists on a recommendation, while disagreement was defined as <70% agreement. The responses from the Delphi study were analyzed using both the content validity ratio and Kendall’s coefficient of concordance.Results. The panel finally evaluated 26 topics, reaching agreement on 9 and failing to reach consensus on 17 after two rounds. While consensus was not achieved regarding the postoperative follow-up period, a duration of 12 months was most commonly adopted. The Valsalva maneuver and questionnaire responses were identified as the most agreed-upon postoperative assessment tools following BDET.Conclusion. Consensus was reached on several recommendations for managing BEDT in obstructive ETD. This agreement will guide future research aimed at defining standard postoperative management for BEDT.
Распространение вариантов вируса SARS-COV-2, вызывающих интерес (VOI) и находящихся под наблюдением (VUM), на основе количества их геномов, депонированных в базу данных GISAID за неделю с 26 октября по 1 ноября 2024 г.
Authors: Дмитриева Людмила , Чумачкова Елена , Краснов Ярослав , Осина Наталья , Зимирова Анастасия , Иванова Александра , Карнаухов Игорь , Караваева Татьяна , Щербакова Светлана , Кутырев Владимир
Published: November 2024

В обзоре представлена информация по циркулирующим в настоящее время вариантам вируса SARS-COV-2 Omicron вызывающих интерес (VOI) и находящихся под наблюдением (VUM), геномные последовательности которых размещены в международной базе данных GISAID за неделю с 26 октября по 1 ноября 2024 г.