bluuebunny/crossref_metadata_2025 huggingface dataset:
Nrf2 Activation by Morinda citrifolia L. (Noni) Fruit Juices
Authors: Manavalan Arulmani , Qader Mallique , Wu Xiaohua , Cao Shugeng
Published: May 2024

Objective:

The objective of the study was to identify Nrf2 activators from differently treated Morinda citrifolia L. fruit juices and their cytotoxicity.

Materials and Methods:

Noni fruit juices were prepared by different treatments: unripe (T1), ripe (T2), purchased (T3), and Noni juices fermented with Lactobacillus plantarum (T4). These extracts were tested for Nrf2 activation and nuclear factor kappa B (NF-κB) inhibition activities. These active extracts were further studied for their nuclear Nrf2 translocation and induction of HO-1 protein expression. Finally, the active extracts were purified using open column chromatography and RP-high pressure liquid chromatography (HPLC) techniques through bioassay-guided separation. Moreover, all Noni juice samples were tested for cytotoxicity using mammalian cell-based methylthiazoltetrazolium (MTT) assay.

Results:

Only purchased (T3) and ripe Noni fruit juices fermented with LP at 22°C (T4–22) showed strongest Nrf2 activation and NF-κB inhibitory activity. Further, these two extracts enhanced the nuclear accumulation of Nrf2 after 2 h and also promoted Nrf2 and HO-1 nuclear translocation. Induction of HO-1 gene expression of Hep G2/ARE cells treated with T3 confirmed that it is a potent inducer of the Nrf2 target gene HO-1. Bioassay-guided separation resulted in subfractions with high Nrf2 activity. The strongest Nrf2 active subfraction led to the identification of scopoletin as an Nrf2 activator. Moreover, none of the tested samples showed any cytotoxicity for the MTT assay.

Conclusions:

The presence of potential Nrf2 activators in the Noni fruit juices that were nontoxic in our MTT assay could mitigate the production of harmful reactive species in the biological systems, and thereby, could helpful in alleviating and prevention of chronic diseases.
Spectrum-Toxicity Correlation Study Revealed the Influence of the Nine-Time Steaming and Sun Drying Method on Hepatotoxic Components of Polygoni Multiflori Radix
Authors: Shi Zhuo , Li Xiao-Fei , Liu Ya-Lei , Li Peng-Yan , Niu Ming , Bai Zhao-Fang , Zhang Guang-Qin , Lu Yang , Wang Jia-Bo
Published: May 2024

Objective:

Polygoni Multiflori Radix (PM) is a traditional herbal medicine with repeated reports of liver injury events in recent years. We wondered whether the classical processing method, namely, nine-time steaming and sun drying (NSSD), had toxicity-attenuating effects on PM and the relationships between toxicity and times of processing, as well as with the alteration trends of its compounds.

Materials and Methods:

The chemical fingerprints of different PM extracts were developed using ultra-high-performance liquid chromatography. The spectrum-toxicity correlation between the chemical fingerprints and hepatocellular toxicity was analyzed with multiple correlation analysis.

Results:

The results suggested that the hepatotoxicity of NSSD processing products markedly decreased with the repeated steaming and sun drying, which was obviously superior to the product processed by the modern method. Comprehensive analysis revealed that the contents of cis-stilbene glycoside and emodin-8-O-β-D-glucoside related to liver injury susceptibility were reduced with the times of NSSD processing, which was consistent with the decreased trend of hepatocellular toxicity. After the five times of NSSD, the contents of them as well as the hepatotoxicity of PM were steady. Moreover, we found that the contents of catechin and physcion declined rapidly after the one time of NSSD and then remained stable until the nine times of NSSD. Based on the fact, they could be utilized to indicate whether PM products were processed by steaming and sun drying.

Conclusions:

This paper confirmed that the NSSD had a good influence on the toxicity attenuating to PM and found four compounds which could apply for the quality control of PM.
An Exploration in the Potential Substance Basis and Mechanism of Chuanxiong Rhizoma and Angelicae Dahuricae Radix on Analgesia Based on Network Pharmacology and Molecular Docking
Authors: Zhao Ting-Ting , Lan Rui-Rui , Liang Shang-Dong , Schmalzing Günther , Gao Hong-Wei , Verkhratsky Alexei , He Chuan-Hua , Nie Hong
Published: May 2024

Objective:

The objective was to study the potential substance basis and action mechanism of Chuanxiong Rhizoma (CX) and Angelicae Dahuricae Radix (AD) on analgesia through network pharmacology and molecular docking.

Materials and Methods:

The active components and targets of CX and AD and pain-related genes were retrieved through Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) and GeneCards database. Then, the co-action targets were found, protein–protein interaction network was constructed by the String database. The Cytoscape 3.7.1 was used to construct “CX-AD-active components-pain” network. Further enrichment analysis of Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) was carried out to predict its mechanism of action, the top four active components in the network were docked with the targets.

Results:

There are 26 compounds, 45 targets in the network. Among them, (Z)-ligustilide and beta-sitosterol, respectively, have more potential targets in CX and AD, and prostaglandin-endoperoxide synthase (PTGS2), PTGS1 have more ligands. GO analysis shows that molecular functions of CX and AD mainly performed through the G protein-coupled amine receptor activity, adrenergic receptor activity, and catecholamine binding. KEGG analysis indicates that they could exert analgesic effect on the pathways of regulating neuroactive ligand-receptor interaction, serotonergic synapse, and cGMP-PKG signaling pathway. Molecular docking results show that the active compounds are highly compatible with the structure of the protein receptor, and they interact through the hydrogen bond and π–π bond between the ligand and the active site residues.

Conclusions:

Through network pharmacology and molecular docking, this study preliminarily revealed the main active components, targets, and potential regulation network of CX and AD, providing a reference for the subsequent experimental research.
Garcinone E Blocks Autophagy Through Lysosomal Functional Destruction in Ovarian Cancer Cells
Authors: Xu Xiao-Huang , Chen Yu-Chi , Xu Yu-Lian , Feng Zhe-Ling , Liu Qian-Yu , Guo Xia , Lin Li-Gen , Lu Jin-Jian
Published: May 2024

Background:

High proliferative rate of cancer cells requires autophagy to maintain nutrient supply and intracellular homeostasis. As a result, impairing autophagic flux could be a novel strategy of cancer therapy.

Aims and Objectives:

In this study, the mechanism of a xanthone derivative isolated from Garcinia mangostana, garcinone E (GE), was investigated.

Materials and Methods:

Fluorescence assay was used to observe the accumulation and location of autophagosome and lysosome. Flow cytometry with Lyso-tracker red, MDC, and AO staining were applied to evaluate the lysosome accumulation and cellular acidity. Western blot and RT-qPCR were performed to evaluate the protein and mRNA levels, respectively.

Results:

GE could cause enhancement of LC3II and p62 and the accumulation of autophagosome and lysosome. Meanwhile, it limited the protein level of Rab7, increased lysosomal pH, and inhibited the maturation of lysosomal hydrolases such as Cathepsin L, therefore blockaded the fusion of autophagosome and lysosome. Moreover, GE acted as a TFEB modulator by downregulating its protein level, which might contribute to autophagy dysfunction in ovarian cancer cells.

Conclusions:

GE interfered autophagosome–lysosome fusion in cancer cells, which demonstrated its application as an autophagy regulator and a potential therapeutic agent.
Линейное хеширование в булевом кубе с кластерами ограниченного размера
Authors: Chashkin Aleksandr Viktorovich
Published: May 2024

Показано, что для произвольного подмножества $n$-мерного булева куба из $M$ элементов существует линейная хеш-функция, кластеры которой состоят не более чем из $a$ элементов, и ранг которой не превосходит ${2\log_2 M-2\log_2 a+\mathcal O(1)}$.
Предельные совместные распределения статистик критериев пакета NIST и их обобщений
Authors: Savelov M P
Published: May 2024

Найдено предельное совместное распределение статистик, являющихся обобщениями статистик критериев пакета NIST и других пакетов, при следующих гипотезах $H_0$ и $H_1$. Гипотеза $H_0$ состоит в том, что тестируемая последовательность состоит из независимых случайных величин с известным полиномиальным распределением, а альтернативная гипотеза $H_1$ соответствует схеме серий, в которой распределение тестируемой последовательности сближается с ее распределением при $H_0$. Примером гипотезы $H_1$ является марковская альтернатива специального вида. В частном случае, когда $H_0$ соответствует последовательности независимых испытаний Бернулли с параметром $\frac12$ и когда $H_1$ сближается с $H_0$, полученные результаты позволяют найти предельные совместные распределения статистик следующих девяти критериев пакета NIST: «Monobit Test», «Frequency Test within a Block», «Runs Test», «Test for the Longest Run of Ones in a Block», «Binary Matrix Rank Test», «Non-overlapping Template Matching Test», «Linear Complexity Test», «Serial Test» и «Approximate Entropy Test», а также их обобщений, при гипотезах $H_0$ и $H_1$.
Clinical Application of Artificial Intelligence in the Ultrasound Classification of Hepatic Cystic Echinococcosis
Authors: Shang Feng , Song Tao , Wang Zhengye , Wu Miao , Yan Chuanbo , Wang Xiaorong
Published: May 2024

Hepatic cystic echinococcosis (HCE) is a zoonotic disease that occurs when the larvae of Echinococcus granulosus parasitize the livers of humans and mammals. HCE has five subtypes, and accurate subtype classification is critical for choosing a treatment strategy. To evaluate the clinical utility of artificial intelligence (AI) based on convolutional neural networks (CNNs) in the classification of HCE subtypes via ultrasound imaging, we collected ultrasound images from 4,012 HCE patients at the First Affiliated Hospital of Xinjiang Medical University between 2008 and 2020. Specifically, 1,820 HCE images from 967 patients were used as the training and validation sets for the construction of the AI model, and the remaining 6,808 images from 3,045 patients were used as the test set to evaluate the performance of the AI models. The 6,808 images were randomly divided into six groups, and each group contained equal proportions of the five subtypes. The data of each group were analyzed by a resident physician. The accuracy of HCE subtype classification by the AI model and by manual inspection was compared. The AI HCE classification model showed good performance in the diagnosis of subtypes CE1, CE2, CE4, and CE5. The overall accuracy of the AI classification (90.4%) was significantly greater than that of manual classification by physicians (86.1%; P <0.05). The CNN can better identify the five subtypes of HCE on ultrasound images and should help doctors with little experience in more accurately diagnosing HCE.
Impact of Sulfadoxine-Pyrimethamine and Dihydroartemisinin-Piperaquine as Intermittent Preventive Treatment in Pregnancy on Stool Antimicrobial Resistance Gene Abundance
Authors: Opoku Kofi B. , Tompkins Kathleen , Waltmann Andreea , Ciccone Emily J. , Bartlelt Luther , Andermann Tessa , Chinkhumba Jobiba , Mathanga Don P. , Gutman Julie R. , Juliano Jonathan J.
Published: May 2024

Increasing antimicrobial resistance (AMR) is a global public health emergency. Although chemoprevention has improved malaria-related pregnancy outcomes, the downstream effects on AMR have not been characterized. We compared the abundance of 10 AMR genes in stool samples from pregnant women receiving sulfadoxine-pyrimethamine (SP) as intermittent preventive treatment against malaria in pregnancy (IPTp) to that in samples from women receiving dihydroartemisinin-piperaquine (DP) for IPTp. All participants had at least one AMR gene at baseline. Mean quantities of the antifolate gene dfrA17 were increased after two or more doses of SP (mean difference = 1.6, 95% CI: 0.4–2.7, P = 0.008). Antimicrobial resistance gene abundance tended to increase from baseline in SP recipients compared with a downward trend in the DP group. Overall, IPTp-SP had minimal effects on the abundance of antifolate resistance genes (except for dfrA17), potentially owing to a high starting prevalence. However, the trend toward increasing AMR in SP recipients warrants further studies.
Biểu hiện, tinh chế Pediocin tái tổ hợp từ nấm men Pichia pastoris X33::ped và thử ứng dụng bảo quản tôm
Authors: Thư Nguyễn Phạm Anh , Thảo Đặng Thị Phương , Nghĩa Nguyễn Hiếu
Published: May 2024

Pediocin là một bacteriocin có kích thước 4.6 kDa, thể hiện hoạt tính kháng khuẩn mạnh trên Listeria monocytogenes và nhiều chủng Gram dương khác. Nhằm thu nhận pediocin với hiệu quả và độ tinh sạch cao cho mục tiêu ứng dụng trong bảo quản thực phẩm, trong nghiên cứu này chúng tôi tiến hành biểu hiện pediocin tái tổ hợp từ nấm men Pichia pastoris X33::ped; tinh chế và thử ứng dụng pediocin để bảo quản tôm. Kết quả thực nghiệm cho thấy 1% là nồng độ methanol cảm ứng chủng P. pastoris X33::ped biểu hiện pediocin tốt nhất. Pediocin tái tổ hợp đã được biểu hiện thành công từ P. pastoris X33::ped sau 72 giờ nuôi cấy trên môi trường BSM với đơn vị hoạt tính của dịch nuôi cấy là 6,400 AU/mL. Quy trình tinh chế pediocin trên cột SP-FF được thiết lập thành công với tốc độ nạp mẫu 155.9 cm/h. Pediocin thu nhận được có độ tinh sạch là 91.7%, lượng pediocin thu nhận được từ 1L dịch nuôi cấy đạt 11.0mg. Pediocin tái tổ hợp thu được có khả năng bảo quản tôm ở 4°C trong 07 ngày. Các kết quả của nghiên cứu này là nền tảng khoa học khẳng định tiềm năng sản xuất pediocin tái tổ hợp từ nấm men P. pastoris X33::ped và ứng dụng trong bảo quản thực phẩm.
NOVEL SAMPAH DI LAUT, MEIRA KARYA MAWAN BELGIA (PERSPEKTIF EKOKRITISISME)
Authors: Marzuqi Iib , Darmawan Taufiq , Sulistiyorini Dwi
Published: May 2024

Penelitian ini bertujuan untuk mendeskripsikan representasi alam, representasi perilaku manusia terhadap lingkungannya, serta interaksi tokoh utama terhadap lingkungannya dalam novel SampahOdiOLaut, Meira karya Mawan Belgia. Jenis penelitian ini adalah deskriptif kualitattif dengan data yang berupa representasi alam, bentuk prilaku manusia, serta lingkungannya. Adapun untuk mengumpulkan data penelitian, peneliti menggunakan teknik simak dan catat dengan instrument lembar korpus data. Data tersebut kemudian dianalisis menggunakan analsisis data kualitatif kualitatif Miles dan Huberman dengan tahapan reduksi data, penyajian data, serta penyimpulan dan verifikasi. Hasil analisis menunjukan bahwa (1) representasi alam dalam novel tersebut berupa laut, sungai, dan pantai, (2) representasi perilaku manusia terhadap lingkungannya membuang sampah sembarangan dan membakar sampah, dan (3) interaksi tokoh utama yaitu Cola/ botol plastik terhadap lingkungannya daun kering yang sengaja mengumpat Cola, persahabatan Cola dengan Aladin, dan rasa sakit Cola ketika dirundung anak-anak angin. Berdasarkan hasil analisis tersebut dapat disimpulkan bahwa terdapat kritikan pemeliharaan alam laut terhadap pembaca berupa representasi alam dan prilaku manusia yang melakukan perusakan laut serta disertai dengan akibat yang ditimbulkan perusakan tersebut melalui tokoh utama yang benama Cola atau botol plastik.Abstract The following research aims to describe the representation of nature, the representation of the form of human behavior, and the representation of the main character's interaction in a novel entitled Garbage in The Sea, Meira by Mawan Belgia. ThePresearchPmethodPused isOdescriptive-qualitative by data the representation of nature, the representation of the form of human behavior, and the representation of the main character's interaction. TheOdataOcollectionOtechniques of thisOstudyOincludeOreading techniques, note-takingOtechniques the instrument of corpus of data. TheOdataOanalysisOtechnique Miles dan Huberman beginsOwith dataOreduction, data presentation, andOendsOwith conclusions and verification. Based on the results of this analysis, it can be concluded that there is criticism of the preservation of marine nature towards readers in the form of representations of nature and human behavior that destroy the sea and are accompanied by the consequences of this destruction through the main character named Cola or plastic bottles.
Egy „Emlékirat” jelentősége Kodály Zoltán pedagógiai koncepciójának tükrében
Authors: Czemmel Antónia Mária
Published: May 2024

Kutatásunk a hazai zenei nevelés és tehetségmentés történetének memorandumát kívánja bemutatni Kodály Zoltán zenepedagógiai írásaira támaszkodva. Erre azért is van szükség, hogy így teljesebb képet kapjunk a „Magyar Állami Énekiskola” intézményesülési történetének fontosságáról, egy eszme iránti mély elhivatottságáról. Tarhos volt az az intézmény, mely egyedüliként indította útjának a kodályi koncepciót, és vállalkozott ezen koncepció módszertani adaptálására: az „úgynevezett népi kultúra talaján szerkesztett zenei tanterve, Kodály közelsége...” (Gulyás, 1988, p. 20.) Magyarországon az 1945-ös eseményekkel lezáruló és elinduló folyamatok vegyes megítélés alá esnek, elsősorban ami a művelődési élet, valamint a nevelésügy alakulását illeti. Sík Sándor a Demokrácia és nevelés című könyv előszavában a következőképpen fogalmaz: „[…] új korszak kezdődik. Új kort csak új emberek teremthetnek. Minden azon fordul, tudunk-e tisztább, egészségesebb szellemű – tegyük hozzá magyarabb szellemű – társadalmat nevelni.” (Sík, 1945, p. 3.) 1945 után felértékelődik az oktatás szerepe: ismét átértékelődött az iskolának a szerepe, fontos célként fogalmazódott meg a vidék elmaradottságának, az analfabetizmusnak a felszámolása, az iskolai életen kívüli népművelés szellemisége is. Nagy felelősség hárult az akkori nevelőkre: remény az új, a jobb jövő megépítésére, a mindenki számára elérhető tanulás, művelődés általi igény az új magyar kultúra megteremtésére. Ehhez lelkes „építőmunkásokra” volt szükség, akik kitartó, elszánt tenni akarással szerettek volna tudást átadni az elmaradott falvakban és tanyavilágban is. A magyar zenei élet nagy hatású gondolkodójának, Kodály Zoltánnak az 1945-ig megjelent zenepedagógiai munkái alkalmat nyújtanak arra, hogy írásait pedagógiai célzattal vizsgáljuk meg a Gulyás György által benyújtott memorandumban, amit öszszehasonító, illetve elemző módszereket alkalmazva igyekeztünk a korábbi kutatásokhoz (Mészáros, 1982, 1989, 1992) kötni, illetve azokat továbbgondolni. Kutatásunk során az intézményben folyó munkát újraértelmeztük, hiszen iskolatörténeti jeléntősége már eddig is ismert volt (Csende, 1976; Gulyás, 1988), de neveléstörténeti jelentőségével még nem foglalkoztak. Éppen ezért olyan fogalmak szemszögéből vizsgáltuk az intézményt, mint azt életreform és reformpedagógiai törekvések vagy a népi gondolat. A memorandum szövege a nemzetnevelő kodályi írásokra támaszkodva mélyebb pedagógiai tartalom feltárására és bemutatására törekszik.
Innovatív vállalkozóképzés és diákstartupok indítása – a Hungarian Startup University Program első tapasztalatai
Authors: Novotny Ádám , Szántó Ákos , Tóth-Boros Nikolett , Bán Szabina , Matiscsákné Lizák Marianna
Published: May 2024

A szakirodalom régóta hangsúlyozza az egyetemek „harmadik missziójának” fontosságát a gazdasági és társadalmi fejlődést illetően. A diákstartup-vállalkozások által megvalósuló innovációknak és a modern vállalkozóképzésnek fontos szerep juthat a helyi térségek fejlődésében, a fenntarthatóság elérésében, valamint a gazdasági válságok idején is. Fókuszcsoportos interjúk segítségével kérdeztünk meg öt egyetemi diákcsapatot, akik a 2020-ban elindult Hungarian Startup University Program (HSUP) keretein belül fejlesztették innovatív ötleteiket. Feltártuk és rendszereztük a diákok gondolatait és érzéseit a program első – pilot – évében. Elemzésünk öt fontos témára mutatott rá a HSUP által megvalósuló újszerű vállalkozóképzéssel kapcsolatban: a diákok motivációira, a tanulást segítő és hátráltató tényezőkre, az egyetem szerepére a vállalkozásindításban, a tanultak hasznosságának értékelésére, valamint a vállalkozói ötlet továbbvitelére. Kutatásunk szerint az egyetemi hallgatók olyan ismereteket, kompetenciákat sajátíthatnak el a HSUP és a hasonló (online) vállalkozói kurzusok teljesítése során, melyek jövőjük, karrierjük és gazdasági szerepük alakulása szempontjából is meghatározóak, iránymutatóak lehetnek.
Az ipari forradalmaktól a fenntarthatóságra nevelésig
Authors: Kovács Mihály , Bárány Edit , Dancsa Dániel , Győrössy Krisztina , Simonyi Sándor Rajmond , Vlaszátsné Vanczer Dóra
Published: May 2024

Neveléstudományi területen kutató doktoranduszokként tanulmányunk fő célja megérteni, hogy az ipar 4.0-val bekövetkező változások milyen mértékben jelennek meg már most az iskolarendszerünkben, illetve milyen oktatási-nevelési célokat kell ennek kapcsán hangsúlyosan megjelentetni az iskolákban. Tanulmányunk első fejezetében áttekintjük az ipar 4.0 történetét. A történelem kapcsán nagy hangsúly lesz azon, hogy hogyan jelenik meg az első három ipari forradalom a történelemkönyvekben. A továbbiakban az ipar 4.0 fogalmáról, az épp lezajlóban lévő és a várható technológiai, gazdasági, társadalmi változásokról lesz szó. Ezt szintén a neveléstudomány szemüvegén keresztül igyekszünk nézni. A technológiai változások kapcsán szó lesz arról, hogy hogyan jelennek meg az új technológiák a fizika és a digitális kultúra tantárgyakhoz készített tankönyvekben. A konklúzióban azonban azt is átgondoltuk, hogy milyen – a neveléstudományban egyébként is fontos – készségek, attitűdök fejlesztésének szükségességére következtethetünk a várható változások kapcsán. Ilyenek az élethosszig tartó tanulás vagy a pozitív környezeti attitűdök.
A transzparens tudat válságáról : Freud tudatkoncepciójának háttere és kritikája
Authors: Torma Anita
Published: May 2024

A racionalista filozófiai irányzatok egyik központi tézise szerint a lelki szubsztancia teljes működését illetően átláthatóvá és megismerhetővé tehető a tudatos elme számára, s erre utal a transzparens tudat filozófiai koncepciója. Freud részben átveszi a tudat racionalista felfogását, de elutasítja azt az elképzelést, amely szerint a psziché kizárólag tudatos és látens mentális állapotokból állna. Jelen tanulmány állítása, hogy Freud tudatfelfogását elsősorban Franz Brentano elmélete befolyásolta, s fő célja, hogy felvázolja, hogyan ered Freud álláspontja Brentano transzparens tudatelméletének részleges adaptációjából. Az elemzés magában foglalja a kartéziánus transzparens tudat tézisének analitikus filozófiai perspektívából való revízióját, valamint Brentano felfogásának fenomenológiai kritikáját Husserl írásai alapján, végül arra a következtetésre jut, hogy a tudatról alkotott racionalista nézetek nem feltétlenül transzparensek abban az értelemben, ahogy azt Freud feltételezte.
A tökéletes minőség és a válságok összefüggésrendszere
Authors: Csorba László
Published: May 2024

A tanulmány a tökéletes minőség modellezését, illetve a modell és a válságok összefüggésrendszerének vizsgálatát tűzte ki céljául. A tökéletes minőség – amely bár ritka, de nem csak elméletben létezik – megteremtésének első lépése valamennyi érintetti követelmény feltárása. Ezt követően a térben és időben egymással ellentétes követelményeket egymással összhangba szükséges hozni. Végül a teljes követelményrendszernek való teljes megfelelést szükséges biztosítani. Mindez „békeidőben” is igen komplex és nehéz feladat. A válságok az érintetti követelményeket bizonytalanabbá, változékonyabbá, ellentmondásosabbá teszik, ami megnehezíti a tökéletes minőség elérését, melyet a források csökkenése is hátráltat. Ugyanakkor a válság egyben lehetőség is innovációk általi „ugrások” végrehajtására, azok érintettekkel való elfogadtatására, mind a követelményrendszer összhangjának, mind a teljes megfelelés elérésének céljából.
Economic structure, export specialization and greenhouse gas emissions in Latin America
Authors: Carrasco Carlos A. , Del-Toro-Rodriguez Blanca B. , Jimenez-Jaime Camila , Hernandez-Garcia Melanny , Obregon-de-la-Garza Paola M.
Published: May 2024

Industrial societies have significantly increased greenhouse gas emissions, resulting in higher average temperatures compared to pre-industrial levels. This has disrupted the socio-environmental balance and led to more frequent extreme climatic events. In response, several organizations have developed strategies that prioritize reducing the environmental impact of human activities. Achieving this goal requires a thorough understanding of the relationship between economic structures and pollutant emissions to elaborate industrial policies that promote a transition to a greener economy. This study focuses on Latin America, a region highly vulnerable to climate change due to its geographical characteristics and reliance on primary sector activities and tourism. Our analysis underscores the necessity of identifying factors that jeopardize socio-environmental sustainability.
Integrating Environmental Sustainability into Macroeconomic Frameworks: The Eco-Keynesian Cross
Authors: Grazini Chiara , Guarini Giulio , Oreiro José Luis
Published: May 2024

The ecological transition hinges on ecological structural change, necessitating smart macroeconomic policies. Incorporating ecological considerations into macroeconomic modelling constitutes a pivotal area of inquiry that examines the nexus between environmental sustainability and economic expansion. This article proposes a macroeconomic modelling to establish a foundational analytical framework to address this challenge. Incorporating ecological considerations into macroeconomic modelling constitutes a pivotal area of inquiry that examines the nexus between environmental sustainability and economic expansion. Contributing to the post-Keynesian Ecological Macroeconomics field, this paper proposes an eco-Keynesian cross due to its simplicity and widespreadness for teaching macroeconomics to illustrate the macroeconomic perspective of green targets strategies in a closed economy. Green public and private investments have the potential to enhance output through the multiplier effect and improve environmental efficiency. However, these investments may also induce rebound effects, resulting in a net increase in pollution intensity within the economy. The model underscores the potential trade-off between social and environmental objectives, which an ecological perspective seeks to surmount by advocating for sustainable and inclusive industrial development.
Exploring Nature's Pharmacy: A Comprehensive Review of Natural Products as Potential Sources of Therapeutic Agents
Authors: . Shalini , Kumari Sushila , Sharma Palvi , Thakur Vandana , Sharma Swati , Kumari Kiran
Published: May 2024

Natural products have been integral to discovering numerous drugs with diverse pharmacological activities. This review provides a comprehensive analysis of the chemical diversity of natural products, their role in drug discovery, and their potential applications in modern medicine. Through critically evaluating recent research findings and case studies, we highlight the significance of natural products as sources of new drugs and discuss emerging trends and challenges in the field. Furthermore, we delve into the intricate interplay between natural products and drug discovery processes, elucidating their indispensable role in shaping therapeutic landscapes. We unveil the transformative potential of natural products as catalysts for novel drug development through a meticulous analysis of recent advancements and case studies. Additionally, we navigate the evolving trends and challenges confronting the integration of natural products into modern pharmacotherapy, offering insights into strategies for overcoming barriers and maximizing their therapeutic impact. In essence, this review serves as a comprehensive roadmap for understanding the multifaceted role of natural products in drug discovery and their profound implications for advancing modern medicine. Through a synthesis of empirical evidence and critical analysis, we aim to inspire further exploration and innovation in harnessing the untapped potential of natural products for addressing unmet medical needs and improving patient outcomes.
Intimacy in Improv
Authors: Richardson Joshua
Published: May 2024

Through the adaptation of trauma-informed pedagogy, intimacy and consent-based practices, and the use of sself-care cues or safe words, this note recounts one lecturer's integration of Consent-Forward practice into their teaching in Higher Education in the UK.
Pengaruh Budaya Kerja, Disiplin Kerja dan Pengalaman Kerja terhadap Kinerja Pegawai pada Kantor Kecamatan Kendari Barat
Authors: Hasriani Hasriani , Muthalib Abd. Azis , Nur Muh.
Published: May 2024

This study aims to determine and analyze specifically how each factor—work culture, work discipline, and work experience—impacts employee performance. This research is explanatory. An explanatory study generally aims to explain the position of the variables studied and the relationship and influence between one variable and another. Based on the research findings, it can be concluded that work culture, work discipline, and work experience have a positive and significant influence on employee performance at the West Kendari District Office. Improvements in work culture, work discipline, and work experience each significantly improve employee performance. That is, any improvement in these three factors will contribute to the improvement of employee performance at the West Kendari District Office.
The Influence of Work Motivation, Work Environment and Job Satisfaction on Employee Performance at CV Lanupi Bandung
Authors: Gunawan Wulandari , Sudaryo Yoyo , Dayona Ismail Gurawan , Suryaningprang Andre , Abdul Aziz Dadan
Published: May 2024

Employee performance is an assessment of work results, and the quality of thinking, behavior and achievements of individuals or teams in achieving organizational goals. This is important to determine the effectiveness and performance of the organization to determine the quality, efficiency and performance of the work carried out by each employee, as well as providing feedback and direction that can improve their performance. Employee performance can be influenced by several factors including, Work Motivation, Work Environment and Job Satisfaction on Employee Performance, The research method used is a quantitative research method with a descriptive and verification approach. The sample in this study was a total sample with a total of 30 respondents. In this study the entire population was sampled, so it is said to be a saturated sample.The research results show that work motivation, work environment and job satisfaction influence employee performance partially or simultaneously with a coefficient of determination test value of 0.753 or 75% so it can be interpreted that 75% of CV. Lanupi (Y) employee performance can be explained by variables work motivation (X1), work environment (X2), and job satisfaction (X3).The research results show that: (1). Employee performance is in the poor category (2). Work Motivation is in the poor category (3) Work Environment is in the poor category (4). Job satisfaction is in the poor category (5). Partial research results show that work motivation influences employee performance (6).
Strategi Kepala Madrasah dalam Meningkatkan Nilai Tambah Pendidikan Era Society 5.0 (Studi Kasus MAN Insan Cendekia Serpong)
Authors: Nikma Sulalatun , Asy'ari Hasyim , Ratnaningsih Sita
Published: May 2024

Education in the era of society 5.0 requires students to have significant added value, this problem indirectly requires teachers to have teaching skills with a digitalization system. This research method is qualitative-descriptive with a case study type. The results of the research show that the planning and implementation of added value in education in the era of Society 5.0 is through: 1) Decentralizing education through a performance-based PPDB system in all regions of Indonesia. 2) Reducing bipolarization through MASTAMA and Olympic and event-based career management. 3) Democratic education through the integration of science and technology and imtak curricula as well as madrasah services in the form of workshops and outreach. 4) Community participation through madrasa committees. 5) Agent of change through the use of laptops, strong social attitudes and religiosity, e-learning systems and LMS, and homestay programs. The value-added model is increasing, as shown by the UTBK results in 2021 and 2022. The number of students entering PTN through the UTBK-SNBT route in 2023 was 89 students out of 114 students or 78%, and students entering through the SNBP achievement route was 22 students out of 56 students or 39.09%. The obstacle faced by the teachers is the lack of communication between the school teachers and the dormitory teachers, which has an impact on program delays that require coordination between the parties involved. The solution is for the madrasa director to open a line of communication between the school and the dormitory so that it can work well and smoothly.
Resolusi Konflik Guru Pendidikan Agama Kristen (PAK) dalam Menciptakan Iklim Belajar yang Kondusif
Authors: Ali Umar , Saingo Yakobus Adi , Kasse Simon , Hayer Alfaris Max
Published: May 2024

The purpose of this study was to determine the conflict resolution of PAK teachers in creating a conducive learning climate. This study uses a qualitative method. Data collection through Focus Group Discussion activities by interviewing 5 PAK teachers and 5 students in class XI SMK Negeri 2 Soe. The data were analyzed using a descriptive approach which discussed the results of the study that conflict resolution for PAK teachers had an impact on creating a conducive learning climate quite well and significantly, which was reinforced by almost all indicators of conflict resolution for PAK teachers that had been implemented optimally, such as giving a chance, discussing problems, compromising, forgiving each other, there is an agreement to maintain order. The implications can be measured from the learning climate indicators, namely the creation of a learning atmosphere away from noise in the classroom, students respect each other, students are not worried about asking questions, students do not go in and out during learning, although sometimes there is still a lack of neatness. However, in general PAK teachers have been able to optimally apply conflict resolution in creating a conducive and comfortable learning climate for students.
Dampak Budaya Organisasi, Kompetensi dan Motivasi Kerja terhadap Kinerja Guru
Authors: Kurroman M. Taufik , Ilhami Susanti Dwi
Published: May 2024

This research aims to obtain proof and analysis of the impact of organizational culture, competence and work motivation on teacher performance at AL Mubaarok Rembang Vocational School. The sampling technique applied was a saturated sample of 38 permanent teachers. The type of research is quantitative with data analysis techniques using multiple linear regression analysis. Data collection was carried out by distributing questionnaires. Research findings show that organizational culture and work motivation have a significant positive impact on teacher performance. On the other hand, competence has an insignificant positive impact on teacher performance. Based on the determination test, the resulting Adjusted R Square value is 0.626, which means that the variables of organizational culture, competency and work motivation can explain teacher performance by 62.6%, while the remaining 37.4% of teacher performance is explained by other variables outside the model.
Pengembangan Kurikulum Ma’hadi dalam Meningkatkan Kompetensi Mahasiswa
Authors: Tsalits Liqo’ Sa’idatuts , Athiyyaturrahmah Athiyyaturrahmah , Aisyah Siti
Published: May 2024

Student Islamic boarding schools are unique and distinctive educational institutions, both in terms of subject (mahasantri) and objects (curriculum and activities). With modernization, the IDIA Prenduan ma'hadi Islamic boarding school provides an adaptive response to adopting a modern education system. This is done by trying to maximize management and curriculum management to produce students who not only have academic knowledge but also instill character values. This research aims to examine the characteristics of the Ma'hadi curriculum and its implications for student character formation. This type of research, field research, in principle relies more on descriptive aspects of data obtained from the field. The results of this research show that the Ma'hadi Islamic boarding school has an educational program that is prepared by itself, where this program contains an educational process that lasts throughout the day in one condition in the dormitory. While IDIA Prenduan uses modern learning methods (tajdid), Ma'hadi Islamic Boarding School has updated its education system with a modern education model where the entire education system starting from teaching techniques, lesson materials, facilities and infrastructure are designed based on the modern education system.
Total Quality Management Strategy for Improving the Quality of Education at Kolej Universiti Perguruan Ugama Seri Begawan (Empirical Study in the Arabic Language Education Master's Study Program)
Authors: Firdaus M. Iqbal , Yusuf Muhamad Hani , Nugroho Wahyu , Fanani Eiffan
Published: May 2024

This research aims to determine the Total Quality Management (TQM) strategy for improving the quality of education in the Arabic Language Education Master's Study Program at Kolej Universiti Perguruan Ugama Seri Begawan (KUPU SB). This research uses a qualitative descriptive analysis method with a case study approach. Data was collected through interviews, observation, and documentation. The research results show that KUPU SB implements TQM by involving all parties, both internal and external, in improving the quality of education. TQM at KUPU SB includes aspects of vision and mission, information, human resources, facilities, competence, and loyalty. The implementation of TQM at KUPU SB has had a positive impact on the university, personnel, and graduates. Universities can compete at a global level, personnel can improve their welfare, and graduates can meet labor market needs. This study is novelty in the field of education quality regarding how KUPU provides facilities and support for activities to develop student potential.
Pemetaan Kerentanan Air Tanah terhadap Pencemaran Berdasarkan Metode DRASTIC di Kecamatan Mojoagung Kabupaten Jombang
Authors: Amini Roisa Tri , Siswoyo Hari , Hendrawan Andre Primantyo
Published: May 2024

Masyarakat di wilayah Kecamatan Mojoagung memanfaatkan sumber daya air tanah melalui pembuatan sumur gali. Air tanah di wilayah setempat berpotensi tercemar oleh limbah industri yang dibuang langsung ke saluran drainase, sungai, dan tanah. Padatnya penduduk di kawasan permukiman berpotensi menghasilkan banyaknya limbah rumah tangga, begitu pula penggunaan pestisida pada lahan pertanian juga berpotensi menjadi sumber pencemar air tanah. Penelitian ini dilakukan dengan tujuan untuk mengidentifikasi sebaran lokasi air tanah yang rentan terhadap pencemaran. Identifikasi lokasi rentannya air tanah dilakukan berdasarkan metode DRASTIC yang memiliki tujuh parameter hidrogeologi. Penelitian dilakukan selama 5 bulan mulai bulan Juli 2023 sampai dengan November 2023 terhadap 28 contoh sumur gali. Hasil yang didapatkan dari penelitian ini adalah nilai indeks kerentanan air tanah berada pada rentang nilai 101 – 156 dengan kondisi tingkat kerentanan rendah hingga sedang. Luas dan prosentase daerah dengan tingkat kerentanan rendah berkisar antara 13,44 km2 (22,3% dari luas wilayah penelitian) sampai dengan 22,74 km2 (37,8%), tingkat kerentanan sedang berkisar antara 37,44 km2 (62,2%) sampai dengan 46,74 km2 (77,7%). Tingkat kerentanan air tanah cenderung semakin rendah pada bagian arah Timur dan Selatan wilayah penelitian, sedangkan kondisi kerentanan sedang mendominasi bagian Barat dan Utara wilayah penelitian.
PERENCANAAN STABILITAS BENDUNG TETAP KADUGENEP KABUPATEN SERANG BANTEN
Authors: Euis Amilia Euis Amilia , Yusup M Ichwanul , M Irfan Rizki
Published: May 2024

Bendung tetap Kadugenep terdapat di sungai Cihaseum. Sub DAS Cihaseum yang memiliki luas lebih kurang 37.65 km2 dan panjang sungai lebih kurang 17.21 km, elevasi di hulu sungai memiliki ketinggian + 167.800 sedangkan elevasi di hilir sungai di sekitar bendung tetap Kadugenep memiliki ketinggian + 113.900 m. Kondisi Bendung saat ini terdapat banyak kerusakan, yang mengakibatkan pengaliran air tidak optimal ke jaringan irigasi, sehingga perlu evaluasi teknis perencanaan. Penelitian ini bertujuan mengetahui  setabilitas bendung tetap rancangan dengan menggunakan debit banjir rencana 100 tahun dengan menggunakan metode Gumbel, dan debit rencana mengunakan metode Hasper, kolam olak menggunakan type Vlughter yang dimodikasi dengan tipe mercu ogee. Hasil perhitungan stabilitas saat air normal tanpa gempa kontrol terhadap guling 2,86 > 1,5, terhadap geser 6,086 > 1,5, kontrol tegangan -0,68 < 2.22 m, tegangan tanah 5,89 < 50 t/m2, daya dukung tanah 117,500 t/m2 > 50 t/m2, Stabilitas saat air normal dengan gempa terhadap guling 2,132 > 1,5, terhadap geser 2,264 > 1,5, kontrol tegangan -1,9008 < 2.22 m, tegangan tanah 5,439 < 50 t/m2, stabilitas saat air banjir tanpa gempa  terhadap guling 3,376 > 1,5, terhadap geser 20,039 > 1,5, kontrol tegangan -1,560 < 2.22 m, tegangan tanah 3,232 < 50 t/m2, stabilitas saat air banjir dengan gempa terhadap guling 3,222 > 1,5, terhadap geser 15,390 > 1,5, kontrol tegangan -2,938 < 2.22 m, tegangan tanah 25,287 < 50 t/m2, dengan demikian stabilitas bendung tetap aman.
Tindakan Preventif dari Pemerintah Untuk Mencegah Adanya Tindakan Itikad Tidak Baik dalam Pendirian Perseroan Perorangan
Authors: Sasongko Octavia Fatma Nur Kusuma Dewi , Maulidayna Ninna , Audina Dhea Januastasya , Rosdiana Anita , Atriani Dewi
Published: May 2024

Dinamika dalam perkembangan konsep Perseroan Terbatas mengalami perubahan pasca diundangkannya Undang-Undang Nomor 11 Tahun 2020 tentang Cipta Kerja. Hal ini merupakan upaya pemerintah yang berusaha mendorong pertumbuhan Usaha Mikro, Kecil, dan Menengah (UMKM) melalui Undang-Undang Cipta Kerja, yang memperkenalkan konsep baru tentang Pendirian Perseroan Terbatas. Tujuan dari penelitian ini adalah untuk mengkaji Tindakan Preventif dari Pemerintah Untuk Mencegah Adanya Tindakan Itikad Tidak Baik dari Pendirian Perseroan Perorangan. Penelitian ini menggunakan metode yuridis normatif dengan menggunakan pendekatan perundang-undangan dan pendekatan konseptual. Hasil penelitian menunjukkan bahwa Pasal 153A Undang-Undang Nomor 11 tahun 2020 mengizinkan pendirian Perseroan oleh satu orang dengan surat pernyataan, yang menimbulkan konflik hukum dengan konsep pendirian tunggal karena kurangnya unsur perjanjian, yang inkonsistensi dengan Undang-Undang Perseroan Terbatas. Oleh karenanya diperlukan tindakan preventif yang diambil oleh pemerintah untuk mencegah tindakan itikad tidak baik dari pendirian perseroan perorangan. Dalam hal ini pemerintah dapat mengambil langkah-langkah seperti penegakan hukum yang ketat, pemantauan aktif terhadap aktivitas keuangan, dan peningkatan transparansi dalam proses pendirian perusahaan perorangan. Selain itu, regulasi yang ketat dan audit rutin juga diterapkan untuk memastikan kepatuhan terhadap aturan dan mencegah potensi penyalahgunaan. Dengan adanya tindakan preventif yang efektif, diharapkan dapat menciptakan lingkungan bisnis yang sehat dan berintegritas, serta mendorong pertumbuhan ekonomi yang berkelanjutan dan inklusif.
Pemerataan Ekonomi melalui Pembagian Bantuan Langsung Tunai (BLT) di Indonesia
Authors: Pahrudin Zia Sahara , Fitri Ajeng Novia , Gusti Sri Ajeng Ratu
Published: May 2024

Kemiskinan adalah masalah yang dihadapi oleh seluruh negara, terutama di negara-negara berkembang dan tertinggal, salah satunya di Indonesia. Akibatnya, kemiskinan di Indonesia meningkat sebagai akibat dari pandemi COVID-19. Masyarakat di seluruh Indonesia telah menghadapi tekanan ekonomi yang signifikan sebagai akibat dari pandemi COVID-19. Selama pandemi, pembatasan aktivitas ekonomi dan mobilitas masyarakat dapat menyebabkan peningkatan kebutuhan akan bantuan sosial seperti Bantuan Langsung Tunai (BLT). Indonesia memiliki masalah yang serius terkait ketimpangan ekonomi dan akses terhadap bantuan sosial mungkin menghadapi tantangan khusus dalam distribusi dan aksesibilitas BLT, yang dapat menyebabkan ketidakmerataan dalam pembagian bantuan. Maka dari itu, penting untuk melakukan monitoring dalam evaluasi yang cermat. Tujuan penelitian ini untuk 1) Menganalisis seberapa efektif program BLT, 2) Mengidentifikasi faktor-faktor yang memengaruhi keberhasilan atau kegagalan program BLT, 3) Menilai dampak social dan ekonomi terhadap penerima program BLT. Metode penelitian yang digunakan adalah jenis kualitatif dengan pendekatan deskriptif. Pengumpulan data dalam penelitian ini melalui studi literatur, seperti: jurnal, buku, penelitian terdahulu, dan informasi dari internet yang dinilai sangat akurat. Hasil kajian pemberdayaan ekonomi melalui BLT di Indonesia menunjukkan bahwa program ini memiliki potensi yang signifikan dalam meningkatkan kemampuan dan kesejahteraan masyarakat kurang mampu serta mengurangi tekanan ekonomi. Melalui pemberian rekomendasi kebijakan yang didasarkan pada analisis efektivitas dan tantangan implementasi, penelitian ini dapat membantu pengambil kebijakan dalam membuat kebijakan yang menghasilkan program BLT lebih efektif dan efisien serta meningkatkan kesadaran akan kebijakan di masyarakat umum. Oleh karena itu, temuan penelitian ini mempunyai implikasi terhadap upaya untuk mencapai pembangunan ekonomi yang lebih disengaja dan berkelanjutan di Indonesia.
Kurangnya Implementasi Sila Pertama Pancasila pada Siswa SD Negeri 106811 Bandar Setia
Authors: Sella Febri Annisa , Estetika Mei Vina , Putri Ribka Trifena , Utami Ridha Uli , Siregar Waliyul Maulana
Published: May 2024

Pancasila adalah lima dasar yang harus diikuti dan diterapkan. Pancasila memberikan pedoman untuk kehidupan berbangsa dan bernegara bagi semua warga Indonesia. Penelitian ini menggunakan pendekatan kualitatif dengan bentuk penelitian deskriptif. Penelitian kualitatif berakar pada latar belakang alami sebagai keutuhan, mengandalkan analisis secara induktif, mengarahkan sasaran penelitiannya pada usaha untuk menemukan teori dasar. Penelitian ini bertujuan untuk mencari informasi mengenai penerapan sila pertama pada jenjang pendidikan formal khususnya jenjang sekolah dasar. Penelitian dilaksanakan pada SDN 106811 Bandar Setia. Hasil dari penelitian ialah antisipasi agar jenjang sekolah mampu menerapkan dengan mapan dari sila pertama pancasila yaitu Ketuhanan Yang Maha Esa.
Mekanisme Pelaksanaan Mutasi Bagi Tenaga Pendidik di Ruang Lingkup SDN Lidah Kulon I
Authors: Madarina Hadyan Bintang , Romadhona Lailatul , Salsabila Putri Bulan , Trihantoyo Syunu
Published: May 2024

Mutasi guru berperan penting dalam menciptakan pendidikan yang baik dan berkeadilan. Ini menjadi fokus utama Dinas Pendidikan Surabaya khususnya pada jenjang Sekolah Dasar (SD) Kota Surabaya. Kinerja para guru akan selalu diawasi oleh kepala sekolah sehingga mewajibkan semua guru memiliki etos kerja yang baik. Metode penelotian ini yaitu kualitatif dengan menggunakan pendekatan deskriptif. Hasil dari penelitian ini adalah mutase guru bisa dilakukan karena ada surat perintah dari dinas pendidikan atau atas dasar kaingin sendiri. Kesimpulan dari artikel ini adalah pentingnya pendekatan yang seimbang, terencana dan terkoordinasi dalam proses mutasi guru serta evaluasi dan adaptasi kebijakan mutasi yang berkelanjutan sesuai dengan perkembangan dan kebutuhan sistem pendidikan.