bluuebunny/crossref_metadata_2025 huggingface dataset:
Symptoms of Attention Deficit Hyperactivity Disorder (ADHD) in Young School-Age Students Diagnosed Using the Moxo Test in the Context of the COVID-19 Pandemic
Authors:   University of Silesia in Katowice, Hetmańczyk Hewilia , Kawiak Ewelina ,   University of Silesia in Katowice, Rychlik Jarosław ,   University of Justice, Warszawa, Poland
Published: February 2025

The global COVID-19 pandemic altered human functioning across many aspects for months, with its effects still felt today in various spheres of life, including education and health. It also held significance in the context of diagnosing developmental disorders in children and adolescents. This paper addresses the diagnosis of core symptoms of attention deficit hyperactivity disorder (ADHD) in younger school-age students before and after the end of the pandemic. It focuses on observed differences in students’ results in terms of attention, reaction time, impulsivity, and hyperactivity. Data was collected using an innovative tool, the d-CPT MOXO test. The study group consisted of students in the initial stage of education, corresponding to ages 7 to 10 in Poland. The findings indicate that COVID conditions did not play an unequivocally negative role in intensifying ADHD symptoms. Negative effects were most evident among 9-year-old girls and to a very limited extent among 7- and 8-year-old girls, as well as 7- and 9-year-old boys. Results also pointed to higher levels of cognitive functioning in MOXO test aspects under COVID conditions compared to pre-COVID conditions in both genders, though a broader range of ADHD symptom reduction associated with the pandemic was observed among boys than girls.
K-Culture Education Methods for European University Students in Korea
Authors:   DongDuk Women’s University, Seoul, South Korea, Moon Hyoung-Jin , Nam Jong-ho ,   Hankuk University of Foreign Studies, Yongin, South Korea, Juszczyk Katarzyna ,   University of Silesia in Katowice
Published: February 2025

This study assesses the awareness of Korean culture among European university students studying in Korea and identifies the most effective teaching methods for them. Data was collected for a month through both quantitative and qualitative methods and analyzed using the SPSS Statistics 30.0 package. The results indicate that European university students prefer the face-to-face educational method when learning about Korean culture, and they find the language and culture teaching method to be the most effective. These findings reflect common trends among European university students studying Korean culture both in Korea and Europe, offering important implications for educators teaching Korean culture.
THE BASIC, TECHNICAL AND TECHNOLOGICAL EDUCATION TEACHER: INSTITUTIONALITY THAT RESEMBLES A PLATYPUS? STRUGGLE FRONTS IN THE TURNS OF A KALEIDOSCOPE;
Authors: SANTOS IVAN LUIS DOS , FREITAS KELMA CRISTINA DE
Published: February 2025

ABSTRACT: This article aims to analyze, in the historical context, the implementation of the Federal Institutes (FIs) and the creation of the career of the Basic, Technical and Technological Education Teacher (EBTT), seeking to problematize the teaching work in its complexity. We used an integrative review of the literature on the subject. The results show that the FIs occupy a prominent role in the Brazilian educational system, by offering a proposal of verticalized academic action, anchored in the indivisibility between research and extension, and materialized by the creation of the EBTT career. The latter, in turn, is part of a spectrum that can oscillate between the poles of innovation-precariousness, especially when observed considering the demands of the neoliberal political project. In this sense, we draw readers’ attention to the need for two struggle fronts, which corroborate the strengthening of the EBTT’s professor identity and the desired project in the law of creation of FIs. They are: 1) Consolidation of a political-pedagogical training, based on the structuring foundations and educational principles of the institution; 2) The construction of a “resistance from within”, which unfolds in the critical re-elaboration of public knowledge, through teaching, research and extension actions, as well as, in the imbrication with the agendas of social movements, unions, and scientific, political, artistic and cultural organizations.
Modified perineal urethrostomy for the management of congenital urethral diverticulum in a 4-month-old feline
Authors: Silva Paloma Helena Sanches da , Maia Mariana Zanini , Barbosa Barbara Vidal , Pimentel Pedro Antônio Bronhara , Masiero Juliana dos Santos , Beier Suzane Lilian , Freitas Patrícia Maria Coletto
Published: February 2025

ABSTRACT: A male, intact, four-month-old feline was referred for veterinary evaluation due to persistent episodes of urinary incontinence that began two months prior, along with a protrusion under the skin in the perineal region. The patient was presumptively treated for cystitis but continued to experience recurrent episodes of urinary incontinence. Following a retrograde contrast urethrocystography and urine collection through guided puncture of the protrusion, a suspicion of urethral diverticulum arose. Therefore, the treatment option was to perform a modified technique of perineal urethrostomy using the diverticulum in the pelvic urethra, through both abdominal and perineal surgical approaches. Two months post-surgery, the patient no longer exhibited clinical signs of urinary incontinence. The modified perineal urethrostomy technique proved to be a viable treatment option for young cats with urethral diverticulum. This is the third case reported in the veterinary literature of a young feline patient with suspected urethral diverticulum that successfully responded to surgical treatment with perineal urethrostomy.
Milking frequency effect on rumination daily profile of dairy cows
Authors: Manfio Amanda Uliana , Hamerski Maria Eduarda Pieniz , Otto Pamela Itajara , Valle Tiago Antonio Del
Published: February 2025

ABSTRACT: Rumination monitoring assesses dairy cows’ health, reproduction, and welfare status. The present study evaluated whether increasing the milking frequency affects dairy cows’ milk yield and daily rumination profile. The database was obtained from cows monitored using collars equipped with a rumination sensor. Cows were milked two (n = 9 and 379 cows) or three (n = 14 and 704 cows) times daily. Increased milking frequency improved (P ≤ 0.05) milk yield from 36.0 to 41.6 kg/cow/d. However, the milking frequency did not affect (P > 0.05) daily rumination or the proportion of diurnal rumination. Diurnal rumination (from 7 to 19 h) generally represents 46.3% of daily rumination. Cows milked twice daily showed a significant decrease in rumination rate, especially during the second daily milking, compared to cows milked three times daily. Thus, milking frequency affects milk yield and reduces rumination during milking. However, it does not affect daily rumination and the proportion of diurnal rumination and can be used as an acidosis marker regardless of milk frequency.
Reformulações na política nacional de saúde mental: análise de dados de assistência no período de 2012 a 2022
Authors: Krefer Laressa Thaís , Oliveira Walter Ferreira de
Published: February 2025

Resumo O artigo tem como objetivo analisar dados de assistência no campo da saúde mental coletiva no Brasil no período de 2012 a 2022, correspondente aos anos anteriores e posteriores à implementação da Nova Política de Saúde Mental. Foi empregada metodologia quantitativa, do tipo estudo ecológico longitudinal. Os dados foram extraídos para o período de 2012 a 2022. As fontes utilizadas foram os sistemas de informação em saúde. Os dados foram compilados em séries temporais e analisados por meio de técnicas de estatística descritiva. Os resultados apontaram fortalecimento dos serviços ambulatoriais e diminuição no crescimento de Centros de Atenção Psicossocial e equipamentos da atenção básica após 2017, indicando conformidade com as diretrizes da Nova Política de despriorizar os serviços de base territorial e comunitária. O quantitativo de hospitais psiquiátricos apresentou pouca variação para todo o período, indicando não apenas concordância com o fortalecimento das instituições hospitalares previsto na Nova Política, mas fragilidades na política de desinstitucionalização do período anterior a 2017. Percebem-se efeitos das mudanças nas políticas nacionais na organização, gestão e execução do sistema de saúde, e, ao mesmo tempo, continuidade em vários aspectos.
About Pharma and Big Pharma
Authors: Guimarães Reinaldo
Published: February 2025

Abstract The text discusses the trajectory of the global pharmaceutical industry towards becoming what is currently called Big Pharma. Also presents the configuration of the Health Industrial Complex and exposes its economic and political dimensions. It suggests as essential determinants of the transformation of the global pharmaceutical industry into Big Pharma the processes of financialization of the global political economy and the harmonization of the intellectual property regime carried out by the World Trade Organization through the TRIPS agreement. Furthermore, it discusses the microeconomic changes that have occurred in the companies’ production process. Finally, it points out that this trajectory is part of the process of weakening multilateral representation built after the Second World War during the 1990s.
OCORRÊNCIA DE ESPÉCIES DE HOMALINOTUS(CURCULIONIDAE: CHOLINAE)EM PALMITEIROS DO GÊNERO EUTERPE
Authors: Zorzenon F.J. , Bergmann E.C. , Campaner C.
Published: February 2025

RESUMO Foi constatada pela primeira vez no Estado de São Paulo, a presença deHomalinotus porosus(GyII.,1836) (Coleoptera: Curculionidae)em plantas deEuterpe edulis eE. oleracea. São descritos seus aspectos morfológicos e comportamentais além dos sintomas de danos. A presença de H. coriaceus e H. deplanatus é relatada pela primeira vez em palmiteiros, embora estas espécies já tenham sido observadas em outras culturas no Estado de São Paulo.
EFEITO DO CONTROLE QUÍMICO NA POPULAÇÃO DE ENNEOTHRIPS FLAVENS MOUL. E NA PRODUTIVIDADE DE CULTIVARES DE AMENDOIM ARACHIS HIPOGAEA L.
Authors: Gabriel D. , Novo J.P.S. , Godoy I.J. de
Published: February 2025

RESUMO Com o objetivo de verificar o efeito do controle químico na população de Enneothrips flavens Moul. e na produtividade do amendoim foram conduzidos dois campos no Centro Experimental do Instituto Biológico, em Campinas, SP, um na safra 1994/95 e outro em 1995/96. Os cultivares de amendoim testados foram IAC-Caiapó, IAC-Jumbo e Tatu (padrão), com e sem controle de E. flavens. Nas parcelas tratadas as pulverizações foram feitas duas vezes por semana e as amostragens realizadas a intervalos de 7 a 15 dias e, para tanto, foram coletados 20 folíolos fechados por parcela, abertos em laboratório, para a contagem de ninfas e adultos, utilizando-se um microscópio estereoscópico. A avaliação da produtividade foi feita através da pesagem do amendoim colhido nas duas linhas centrais de cada parcela, após secagem em casa de vegetação. Os resultados obtidos evidenciam que houve efeito das pulverizações na redução da população para os 3 cultivares, sendo que a melhor resposta ao tratamento químico foi verificada para o cultivar Tatu. Entretanto não houve correspondente aumento nas produções, exceto para o cultivar IAC-Jumbo que, na safra 1995/96, apresentou produtividade de 2.422 Kg de amendoim em casca por hectare, quando tratado e 1.198 Kg sem tratamento.
Influence of habitats on fish assemblages in tropical marine coastal areas of the Southwestern Atlantic
Authors: Lima Júnior Márcio J. C. A. , Nunes José A. C. C. , Sampaio Cláudio L. S.
Published: February 2025

Abstract In the Southwestern Atlantic, estuarine and marine habitats connect to form biodiverse coastal landscapes. However, the structuring relationships of the assemblages in these landscapes are not yet fully understood. In this context, we sought to investigate the composition of fish assemblages from estuarine and marine habitats: mangroves, artificial structures, sandstone and coral reefs. We also sought to understand the relationship between the assemblages of these habitats by means of similarity. The research was carried out in the RESEX de Jequiá (RXJ) - AL and in Porto Seguro (PTS) - BA, using single Baited Underwater Video (BRUV). At total, 80 samples were taken (40 per location). The coral reef samples stood out significantly, with the greatest richness and abundance at both locations. RXJ had 18% similarity between its habitats, while PTS had 31%, indicating a relationship and the sharing of species in the composition of their assemblages. Sandstone reefs proved to be structural links between mangroves and coral reefs. Additionally, habitat characteristics and depth significantly influence the composition of the assemblages. Here we highlight relevant information for tropical areas little investigated by science in the Southwestern Atlantic, especially with regard to the importance of coastal sandstone reefs.
Outlines of the professional core of occupational therapy in mental health based on its objects, objectives and instruments
Authors: Constantinidis Teresinha Cid , Colato Érika Regina de Oliveira , Ricci Thamy Eduarda , Costa Fabiola da Silva , Dantas João Gabriel Trajano , Melo Cleber Henrique de , Rocha Laura Sanches , Krutli Renata Luiza dos Santos , Faria Isabela Brito Alves de , Lussi Isabela Aparecida de Oliveira
Published: February 2025

Abstract Introduction In scientific meetings there has been a need to discuss occupational therapy practices in mental health from the professional core. Objective To outline the professional core of occupational therapy in Mental Health in Brazil, through its objects, objectives and instruments, verified in scientific production on the practice of this professional. Method This is a bibliographical search to survey occurrences of themes related to the elements object, objective and instruments. 71 articles were analyzed from a previous study, which approached articles until 2018, adding the search update for 2022. Results Among the elements analyzed, it is worth noting that most studies point to activity as a professional object. Daily life, which is also addressed as an object, supports knowledge that, when applied to professional practice, presents specificities in the approach and intersections with the field of mental health. The objective element presented as main themes social participation, autonomy, inclusion and social emancipation, which are interrelated with the principles of Psychosocial Care in Brazil. The instruments of greatest expressiveness were the activity, the group and the workshop. Conclusion While for other professionals working in the field of mental health, activity is a resource — a support or aid in their interventions —, for occupational therapists, it constitutes a fundamental instrument for achieving objectives, which are inseparable from the field of psychosocial care. The performance of occupational therapists in territorial, intersectoral and interprofessional work in the field of mental health stands out.
ENFERMEDAD LINFOPROLIFERATIVA EN LA COLUMNA: FACTORES PREDICTIVOS DE COMPLICACIÓN POSTOPERATORIA
Authors: TRINCADO RAFAEL MORAES , DURIGAN JORGE RAFAEL , MONTEIRO FELIPE NEVES SIMÕES , GARCIA JOÃO TOMÁS FERNANDES CASTILHO , ALEXANDRE MURILO , MENDONÇA RODRIGO GÓES MEDEA DE , GOTFRYD ALBERTO OFENHEJM , CAFFARO MARIA FERNANDA SILBER , MEVES ROBERT
Published: February 2025

ABSTRACT Objectives: This study aimed to analyze predictive factors for postoperative complications in patients with lymphoproliferative disease in the spine. Materials and Methods: An observational retrospective study was conducted at a quaternary service between 2017 and 2021. Postoperative complications, 1-year survival, and correlations with Karnofsky, SINS, and ASIA scales were evaluated. Results and Discussion: Of the 23 participants, 21.7% experienced postoperative complications, with laminectomy + arthrodesis being the most common procedure. Patients with lower Karnofsky scores showed a higher incidence of complications, while 1-year survival was 60%, which is correlated with preoperative functionality. Factors such as Karnofsky and ASIA are relevant for predicting complications and survival. Patients with preoperative functional impairment had worse outcomes, corroborating previous studies. Conclusion: Multifactorial evaluation, including Karnofsky and ASIA, is essential for planning the treatment of patients with lymphoproliferative disease in the spine, aiming to reduce postoperative complications and improve survival. Level of Evidence IV; Observational Retrospective Study.
Pathogenetic interrelations of hypogonadism and depression in men
Authors: Bulanov V.S. , Litvinov A.V. , Gorobets L.N. , Akhmedova A.A.
Published: February 2025

The study of the relationship between depression and functional hypogonadism in men is an interesting and difficult task. The purpose of the presented review was to identify the problem of functional male hypogonadism, to show a complex multi-stage neurohumoral mechanism of regulation of its potential to influence the affective sphere and to address the influence of pharmacotherapy on the formation of sexual disorders in men. The primary search for literature data was conducted using PubMed (Medline), PsycINFO and Cochrane CENTRAL, e-library.ru, databases using the keywords «hypogonadism», «depression», «testosterone», «antidepressants», «antipsychotics». As a result, 63 sources of information were selected and analyzed. Among the selected papers, there were 2 meta-analyses, 12 reviews and 42 comparative studies, including longitudinal, cross-sectional and controlled studies, 7 practical manuals. Based on the data obtained, it is possible to draw conclusions about the relationship between depression and functional hypogonadism as well as about the possibility of pathogenetic mechanisms of depression to cause changes in the state of the hypothalamic–pituitary–gonadal axis, leading to hypogonadism and vice versa, the ability of hypogonadism to form and enhance depressive symptoms. The concept of the mechanisms of regulation of steroidogenesis can allow the development of alternative methods of therapy and augmentation of depressive disorders, minimization of the number of sexual dysfunctions of psychopharmacotherapy. Further large-scale studies are needed for an in-depth study of this topic and the resolution of a number of contradictions.
Using practice questions based on Bloom’s taxonomy to improve quality of learning of block release students in Zimbabwe: A case study of public policy analysis module
Authors: Kwandayi Hardson , Muyambo Tenson
Published: February 2025

The paper observes that nearly all universities in Zimbabwe offer crash academic programmes that are commonly referred to as block release because students attend their face-to-face classes for a short space of time. The Covid-19 pandemic has intensified the use of block release. During block release sessions, students are taught all the course content for the whole semester which usually includes four courses. After the intensive face-to-face lessons, students are expected to write their assignments and then come back to write their final examinations at the end of the semester. The paper contends that the block release mode of instruction is typical distance education and therefore requires continuous student-instructor interaction through use of well-planned practice questions based on the course syllabus. To be effective, the paper suggests that the practice questions should be based on Benjamin Bloom’s taxonomy of questions. The questions focus on key verbs which include remember (or recall), understand, apply, analyse, evaluate and create. This approach enables students to master various types of knowledge which are factual, conceptual, procedural and metacognitive. The paper uses illustrative questions from public policy analysis which is a relatively new discipline in the context of Zimbabwe. The illustrative questions can also be applied across disciplines such as Family and Religious Studies, History and Geography.
A case study on the advantages and disadvantages of using Blackboard Collaborate in the Health Sciences Faculty at the University of the Free State
Authors: Phejane Mojaesi Violet
Published: February 2025

Using a case study approach, this paper aims to explore the advantages and disadvantages of using Blackboard Collaborate as a tool for achieving increased access to Online education and training. The Health Sciences Faculty at a South African university uses methods of open education practices through Blackboard Collaborate for students in the Free State and across South Africa as well as internationally. The qualitative interpretive paradigm with descriptive research methods was used with seven lecturers and personnel interviewed on the effectiveness of this tool in supporting students’ online learning, backed by the Constructivist Learning theory. The use of Blackboard Collaborate effectively assists students who work and cannot attend classes to gain access to information through recorded videos and attending seminars online. Student grades improved in one of the modules: Interprofessional Education (NVER 4518/IPE), which relied on the use of Blackboard Collaborate. Findings show an improvement in student engagement in modules like MBchB_1-5 through the extensive use of Blackboard Collaborate, for not only delivering lessons but also in relaying essential messages. Using Blackboard Collaborate does not only help improve student grades but also opens possibilities of increased access to education and training opportunities. Blackboard Collaborate is used for multiple educational reasons such as broadcasting seminars, Departmental meetings, classes, first-year welcoming into the university as well as hosting tutorials online in aiding student access and success. Recommendations include advantages and disadvantages of using Blackboard Collaborate, feedback on the experiences and improvements in using this online teaching and learning teaching tool to achieve sustainable Open Education practices successfully.
A study investigating ways to entice teachers who have left the teaching profession to return
Authors: Palm Alice
Published: February 2025

Early departure from the profession may result in a shortage of qualified teachers and may negatively affect learner performance. The loss of teachers from the profession before retirement age is a challenge faced by developed and developing countries across the world. This study seeks to determine the conditions under which teachers who had left the profession might consider returning. A qualitative study framed within the Self-Efficacy Theory, was conducted. The participants consisted of 14 qualified teachers who had left the teaching profession within their first ten years of teaching. The research instrument used constituted in-depth interviews conducted in-person and online. A thematic data analysis was conducted and the themes and categories that emerged from the data were interpreted. The results indicated that teachers who had left the profession would return if their concerns regarding provision of a supportive environment, adequate remuneration, manageable workload, a more desirable curriculum and sufficient resources, were addressed. Findings are that teachers who return to the profession should be phased in with regards to their workload and the number of administrative duties. The value of this study lies in answering a paucity in recent research and literature on prerequisite conditions for teachers to return to the profession.
Teachers’ strategies to develop leadership skills in Foundation Phase learners
Authors: Mulovhedzi Shonisani Agnes , Joubert Ina (Jacobina Christiana)
Published: February 2025

This research paper focused on the strategies employed by teachers in the development of leadership skills in learners at the Foundation Phase. The study aimed at exploring the strategies which teachers employ in developing Foundation Phase learners to embrace sound leadership attributes as young learners must develop and assume leadership roles at an early stage. A purposive sampling procedure was followed to select eight Grade 3 teachers from four government primary schools. The study was qualitative in nature and data were collected through focus-group discussions, capacity building workshops and observations. Data were merged into relevant themes using thematic analysis. The study was grounded in participatory action research with Erikson theory of psychosocial development and transformational leadership theory as its theoretical framework. The main finding was that the strategies suggested and adopted by the participating teachers in the development of leadership skills in the Foundation Phase showed a significant effect on the learners' behaviour, performance, willingness and readiness to perform in various leadership roles.
COMPONENT OPTIMIZATION OF g-C3N4/TiO2 HETERO- STRUCTURE COMPOSITE AND ITS ACTIVITY ENHANCEMENT FOR PHOTOCATALYTIC DEGRADATION OF RHODAMINE B
Authors: Cao Zikang , Liu Yating , Wang Luqi , Gao Xu , Chen Sitian , Cheng Sitian , Yu Yan , Li Li
Published: February 2025

In this study, g-C3N4/TiO2 heterostructure composites were synthesized using sol–gel and hydrothermal methods. Through X-ray powder diffraction (XRD) and X-ray photoelectron spectroscopy (XPS), the crystalline phase structure and chemical composition of the composite were confirmed. Scanning electron microscopy (SEM) revealed that the g-C3N4 sheets were uniformly dispersed on the block TiO2 particles. Ultraviolet–visible diffuse reflectance spectroscopy (UV–Vis/DRS) indicated that the incorporation of g-C3N4 resulted in a narrowing of the forbidden bandwidths of the composites. Photoluminescence (PL) spectroscopy and electrochemical impedance spectroscopy (EIS) further demonstrated that the g-C3N4/TiO2 heterostructure effectively suppressed the recombination of photogenerated charge carriers. To evaluate the photocatalytic performance of g-C3N4/TiO2 heterojunction composites, different g-C3N4 loadings were tested for degradation of rhodamine B (RhB). The 7.62 w/% g-C3N4/TiO2 heterojunction composite exhibited the highest degradation efficiency for RhB dye, with a constant degradation rate that was twice as high as that of pure TiO2. Additionally, experiments on free radical trapping of the composite revealed the crucial role of hydroxyl radicals (·OH) and photogenerated holes (h+) in the RhB degradation. Moreover, the formation of a Z-scheme heterojunction between g-C3N4 and TiO2 was the main factor in further enhancing the degradation activity of the composite.
RESEARCH ON THE WATER-HOLDING CAPACITY AND MECHANICAL PROPERTIES OF BACKFILL BASED ON A DAMAGE-SOFTENING CONSTITUTIVE MODEL: EFFECTS OF DIFFERENT PERMEABILITY FORCES
Authors: Yang Chaoyi , Huang Zhenggao , Sha Wenzhong , Huang Heng , Gao Rugao
Published: February 2025

This study investigates the application of tailings backfill through a series of centrifugal and pore characteristic tests. To align with the material’s structural properties, a specialized test mold was developed, enabling the preparation of tailings backfill model samples with varying concentrations and proportions. Employing centrifugation and nuclear magnetic resonance (NMR), the study determined the optimal centrifugal force and the T2 critical value for the backfill material. By simulating seepage pressures induced by different centrifugal speeds, uniaxial compression mechanical tests were conducted to analyze the effects of seepage forces on the deformation characteristics and failure modes of the backfill. The results revealed that as seepage force increased, the stress-strain behavior of the samples was altered, with failure modes transitioning from tensile failure to shear failure. This shift was accompanied by an increase in the crack propagation and morphological complexity. Based on these findings, a damage-softening constitutive model incorporating penetration forces was established and validated against experimental data, demonstrating strong agreement. This model provides a robust framework for analyzing uniaxial compression mechanics of backfill materials under varying penetration forces. The outcomes of this research provide valuable insights into high-gravity centrifugal simulations and underground seepage tests, contributing significantly to the design and safety evaluation of tailings backfill systems.
Catalytically Inactive SHP1-C453S Mutant Gain of “Robust LLPS” Function
Authors: Qichen Zhang , Tianyue Sun , Qi Chen , Guangya Zhu , Xiangyu Kong , Yiqi Du
Published: February 2025

SHP1 is a non-receptor protein tyrosine phosphatase extensively expressed in hematopoietic cells, exerting a pivotal role as an immunosuppressive factor. Our previous studies have suggested that SHP1 can undergo liquid-liquid phase separation (LLPS). In this study, the SHP1-C455S mutant, commonly utilized in biochemical assays due to its lack of catalytic phosphatase activity, unexpectedly exhibited a remarkably robust ability for LLPS. Since the C453S mutation has been previously shown to potentially induce a conformational transition of SHP1 from a closed to an open state, we hypothesize that the enhanced LLPS capability of SHP1 may be facilitated by this conformational alteration. The SHP1-C453S mutant exhibited robust LLPS activity, while completely abrogating its phosphatase activity.
This allows for effective investigation of the catalytic activity and LLPS capability of SHP1.
A Brief Review of Clinical Considerations for Healthcare Provider-Administered Cardiovascular Risk Modifying Medications
Authors: Atif Ibrahim , Sumair Ozair , Gene Gerlach , Berry Bertolet
Published: February 2025

Cardiovascular Disease (CVD) remains a major contributor to morbidity and mortality, with effective lipid management being essential in reducing Atherosclerotic Cardiovascular Disease (ASCVD) risk. While statins have long been the primary treatment, barriers such as intolerance, poor adherence, and clinical inertia often prevent patients from achieving optimal Low-Density Lipoprotein Cholesterol (LDL-C) levels. Despite the availability of alternative lipid-lowering therapies (LLTs), many patients still fail to meet recommended targets. The introduction of provider-administered LLTs, like inclisiran, presents a promising strategy to enhance adherence through in-office administration under a “buy-and-bill” model. This approach improves treatment continuity, reduces administrative hurdles, and may alleviate financial constraints, particularly for Medicare beneficiaries. Implementing this model successfully requires coordinated efforts, including provider education, infrastructure development, and streamlined reimbursement processes. As cardiovascular care continues to advance, provider-administered LLTs may play a critical role in improving patient outcomes and mitigating the burden of ASCVD.
Collection of protocols related to Article - Proteostasis and lysosomal repair deficits in transdifferentiated neurons of Alzheimer's disease v1
Authors: Chou Ching-Chieh , Frydman Judith
Published: February 2025

A collection of protocols used in the study.
THE IMPACT OF CONVOLUTIONAL NEURAL NETWORKS AND PYTHON ON BRAIN TUMOR DETECTION
Authors: Hamza Aggoun , Ahlam Labdaoui , Guler İnan , Brahim Rouibah
Published: February 2025

Brain tumors are a broad category of disorders distinguished by abnormal cell development in or around the brain. Scientists have found over 150 varieties of brain tumors, which may be roughly classified as benign (noncancerous) and malignant (cancerous). Because of their complexity and variety, this disease poses considerable diagnostic hurdles. Timely and precise detection is critical to effective analysis.

This article investigates the use of adaptable deep learning system, notably convolutional neural networks (CNN), in evaluating MRI images to detect brain tumors. In this work, we created a novel adaptable deep learning system that takes into consideration the well-known transfer learning approaches for MR classification of images. Applying code written in Python, this architecture aims to execute these important tasks properly. Our proposed technique was assessed using a dataset for brain tumor investigation utilizing MRI images, containing 700 brain imagery, 350 of which had tumors. The technique confirmed its capacity to reliably detect brain cancers in the MR images.

At the test stage, the system beat existing conventional approaches for identifying brain tumors, getting accuracy scores of 98.06%, F1 Scores of 98.27% and sensitivity of 100%, respectively. We adopted data split to train the model: 75% of our dataset was used for training, 25% for testing.

The suggested deep learning context and other known as transfer learning approaches were evaluated on an identical MRI dataset. Additionally, the study provides future recommendations for further research in this area.
SHEVCHENKO'S "HAYDAMAKS" AND STANISLAV ZINCHUK'S POEM "CALL"
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Naienko Mykhailo
Published: February 2025

This article deals with the thematic affinity, but also differences, of T. Shevchenko's poems "Haydamaky" and Stanislav Zinchuk's "Sklyk". The author analyzes the historical basis of the poems and at the same time discusses the dissimilar treatment of certain plot motifs in them. He uniquely reveals the view of historical and artistic truth in both poems, and also draws attention to the genre and style features of the works as lyric-dramatic poems and their belonging to the romantic wing in Ukrainian epic poetry.
Francisco de Quevedo, España defendida, y los tiempos de ahora, de las calumnias de los noveleros y sediciosos
Authors: Moya del Baño Franciso , Miralles Maldonado José Carlos
Published: February 2025

España defendida es una obra inacabada de un joven y combativo Francisco de Quevedo que se ha conservado en un manuscrito autógrafo que hoy guarda la Biblioteca de la Real Academia de la Historia (Madrid). Se trata de una defensa de España y de sus gentes de las calumnias y ataques recibidos, que puede también leerse como una entusiasta y erudita laus Hispaniae. La obra no llegó a acabarla, pero tal como quedó es un testimonio muy válido para conocer a Quevedo, sus lecturas, sus ideas, y su época.
Esta nueva edición pretende ser fiel a la vocación filológica de Quevedo, y ofrece un texto correcto y más fácil de leer, con modernización de grafías, puntuación, división en párrafos, así como corrección de no pocos "errores" evidentes. Se localizan fuentes y citas en griego, latín o hebreo. Un nutrido número de notas dan luz a un texto complejo y muestran con claridad las obras que sustentan la génesis de la obra. En la bibliografía queda a las claras cuál era la biblioteca de la que se sirvió Quevedo.
Francisca Moya del Baño es catedrática emérita de Filología latina de la Universidad de Murcia. José Carlos Miralles Maldonado es catedrático de Filología Latina en la Universidad de Murcia, y José Manuel Cañas Reíllo, es Doctor en Filología latina y licenciado en Filología Clásica y Filología Bíblica-Trilingüe.
Anacreón castellano
Authors: Gallego Moya Elena , Castro de Castro J. David
Published: February 2025

El Anacreón castellano de Quevedo fue la primera traducción o paráfrasis completa al castellano de las Anacreónticas, un conjunto de odas dedicadas a cantar, sobre todo, el vino y el amor, escritas por diversos poetas griegos de épocas distintas. El humanista Henri Estienne (Henricus Stephanus), su primer editor, las atribuyó en el año 1554 al poeta arcaico Anacreonte, y esta atribución se mantuvo a lo largo de siglos. Quevedo decidió trasladar al español a “Anacreonte”, cuya obra admiraba profundamente y lo hizo en una hermosa paráfrasis poética, con comentarios a algunas odas.
Nuestra edición presenta algunas novedades: se ofrecen, por primera vez, las traducciones de algunos textos clásicos que Quevedo incorpora en sus comentarios y que solo se encuentran en un manuscrito de muy difícil lectura, conservado en Nápoles. Se localizan, además, todas las citas clásicas que aparecen en su obra y se identifican las ediciones que utilizó. Otra novedad importante deriva del hallazgo de nuevos manuscritos, que han servido para enriquecer la colación y mejorar el texto. La edición la hemos acompañado del texto griego y de las traducciones latinas que sirvieron a Quevedo para realizar su paráfrasis. Por último, el estudio y notas que se ofrecen pretenden ayudar a la comprensión de esta obra de Quevedo.
Diego López. Las Sátiras de Persio. Texto latino y traducción extraídos de su Declaración magistral
Authors: Del Amo Lozano Milagros
Published: February 2025

Diego López, humanista español que tradujo y comentó a Virgilio (1601), Alciato (1615), Valerio Máximo (1631), y Juvenal (1642), realizó unos comentarios a las Sátiras de Persio que se publicaron en Burgos en 1609: Aulo Persio Flacco, traduzido en Lengua Castellana, por Diego Lopez, natural de la Villa de Valencia, Orden de Alcantara, y Preceptor en la ciudad de Toro. Con declaracion Magistral, en que se declaran todas las Historias, Fabulas, Antiguedades, versos dificultosos y moralidad que tiene el poeta. En esta publicación, Diego López ofrecía la primera traducción al español de la obra del satírico, mezclada con las abundantes explicaciones que, partiendo de Comentarios anteriores escritos en latín, aporta el autor al entendimiento de las Sátiras. Milagros del Amo ofrece exenta la traducción de Persio junto al texto latino que López traduce, lo cual ha logrado tras un análisis en profundidad del conjunto de la obra del humanista. La edición bilingüe (latín-español) que se ofrece va precedida de un pertinente y exhaustivo estudio.
Análisis de la red de palabras clave en revistas científicas electrónicas
Authors: Paulo Müller Fernandes Rogerio , Maria Nogueira Cervantes Brígida , Luiz Contani Miguel
Published: February 2025

Comprender la organización del conocimiento es un paso importante para entender el propio conocimiento científico y sus avances para la sociedad. Para hacer frente a los desafíos de un entorno digital en constante crecimiento, desterritorializado y cada vez más complejo, la Ciencia de la Información requiere diferentes aportes metodológicos que le ayuden a tratar la diversidad actual de redes y sistemas de información. Mientras que las redes sociales se basan en las relaciones entre personas, grupos u organizaciones, las redes de palabras clave se basan en las relaciones entre las palabras. Palabras que, cuando están presentes en un artículo, frase o mensaje, adquieren distintos vínculos que pueden dar lugar a redes con relaciones aún no explícitas. El análisis de las redes de palabras clave formadas a partir de artículos científicos publicados, que es el objetivo de este trabajo, permite no solo identificar los principales temas investigados, las tendencias y la evolución en el área, sino también determinar las relaciones de diferentes investigadores con los temas descritos. En este contexto, el objetivo del estudio fue examinar las tendencias y destacar las palabras clave más comunes en el dominio de una revista científica electrónica, a partir de las redes científicas que pueden identificarse.
Dimensional Stability and Accuracy of Silicone Impression Materials After Ozone Water Disinfection: An In Vitro Study
Authors: Kutralanathan Abinaya , Chidambaranathan Ahila Singaravel , Balasubramaniam Muthukumar
Published: February 2025

Objectives: This study evaluated the effect of ozone water disinfection on dimensional stability and accuracy of silicone impression materials.
Materials and Methods: According to ISO-4823, a stainless-steel die was fabricated for this in vitro study. Three horizontal parallel lines, namely x, y, and z (25, 50, and 75µm in width and 25mm in length) running perpendicular to two vertical lines, namely D1 and D2 (0.075±0.008mm wide), were created on the superior surface of the die. Group A served as the control group with no disinfection. Disinfection was performed with 2% glutaraldehyde in group B, 5.25% sodium hypochlorite in group C, and ozone water in group D for 10 minutes. Totally, 60 samples were fabricated. The silicone impression samples were allowed to polymerize in a thermostatically controlled water bath at 35±1ºC for 10 minutes. The dimensional stability and accuracy of the silicone impression samples were evaluated by using a video measuring microscope and an optical microscope. Data were analyzed by two-way ANOVA followed by post-hoc analysis with the Scheffe test (alpha=0.05).
Results: The highest dimensional stability (25.01mm) and accuracy (25.02µm) were seen in addition silicone putty and light body impression with ozone water disinfection, and the lowest parameters were seen in condensation silicon putty and light body disinfected with 2% glutaraldehyde (24.87mm and 24.88 µm, respectively); this difference was statistically significant (P<0.001).
Conclusion: Ozone water disinfection caused minimal changes in dimensional stability and accuracy when compared to 2% glutaraldehyde and 5.25% sodium hypochlorite disinfection.
Amniotic Allograft with Coronally Advanced Flap for Treatment of Gingival Recession: A Randomized, Controlled Clinical Trial
Authors: Kondepudi Lakshmi Kalyani , Koneru Suneetha , Dwarakanath C.D.
Published: February 2025

Objectives: Amniotic membrane (AM) is an allograft obtained from humans that contains a variety of growth factors, and has outstanding healing qualities. This study aimed to assess the efficacy of amniotic allograft with coronally advanced flap (CAF) for root coverage.
Materials and Methods: This randomized controlled clinical trial comprised 24 individuals with Miller's Class I and II root resorption defects. Each patient received treatment using the CAF approach, with the test group receiving a combined therapy using an AM. Measurements were made at baseline and 6 months after surgery for gingival biotype (GB), dentin hypersensitivity (DH), recession depth (RD), recession width (RW), gingival recession total surface area (GRTSA), keratinized tissue width (KTW) and probing depth (PD).
Results: There was a statistically significant reduction in RD (from 2.83 mm to 0.92 mm), a significant increase in KTW (from 3.17 mm to 4.25 mm), improvement in GB, and a reduction in DH in the test group compared to the control group (P<0.05).
Conclusion: Miller’s Class I and II root recession defects can be effectively treated with a CAF. Application of AM under the CAF improved root coverage and GB, and further increased the KTW after 6 months, compared to CAF alone.
Comparative Antifungal Efficacy of Curcumin Plus Nystatin Versus Nystatin Monotherapy for Treatment of Denture Stomatitis: A Clinical Trial
Authors: Meftahpour Haniye , Leasan Simin , Jafariazar Zahra , Farrokhnia Taraneh
Published: February 2025

Objectives: This study compared the antifungal efficacy of curcumin plus nystatin versus nystatin monotherapy for treatment of denture stomatitis.
Materials and Methods: This single-blind clinical trial evaluated 32 patients with types II and III denture stomatitis. Microbial samples were collected from the patients’ palate to count the Candida albicans (C. albicans) colonies. Erythema of the palate was quantified by measuring the surface area of the erythematous sites. The patients were randomly assigned to two groups (n=16). The control group received nystatin suspension while the test group received a curcumin mouthwash plus nystatin suspension. The number of C. albicans colony forming units (CFUs) and the surface area of the erythematous sites were calculated again after 14 days. Data were analyzed using t-test and Wilcoxon signed-rank test (alpha=0.05).
Results: Both groups experienced a significant reduction in C. albicans colony count after the intervention (P<0.001). There was no significant difference in reduction of colony count between the two groups (P=0.341). Both groups experienced a significant reduction in the size of erythema (P=0.001 for the nystatin and P<0.001 for the nystatin plus curcumin). The two groups were not significantly different regarding the size of erythema at baseline (P=0.956) or after the intervention (P=0.491).
Conclusion: Addition of curcumin to nystatin suspension did not add any significant advantage with regard to reduction of C. albicans colony count or erythema of the palate, and both interventions were equally effective.
Grothite from schists of the Irtysh Shear Zone (East Kazakhstan)
Authors: Nastavko E. , Fedosyuk G. , Zmeev B.
Published: February 2025

Grothite, a rare fluorine-alumina variety of titanite, was found and studied in the shales of the Irtysh shear zone (Eastern Kazakhstan). The mineral composition was defined Tescan Vega3 scanning electron microscope (SEM). The Al2O3 and F contents, which are not typical for titanite, allowed classifing it as Al-F titanite (grothite). In addition to alumina and fluorine, the studied grothite contains FeO and Y2O3. The general formula of the mineral is as follows: (Ca0.94—1.02Y0.02—0.04Fe0.01—0.02)Ʃ0.99—1.04(Ti0.83—0.89Al0.11—0.16)Ʃ0.94—1.02(Si0.95—0.99Al0.01—0.05)Ʃ1.00O4(O0.86—0.91F0.09—0.14)Ʃ1.00.
The maximum contents of Al2O3 and F are characteristic of the central parts of large grains of grothite from muscovite-biotite schists, and the minimum for small grains of grothite from biotite schists, which, apparently, reflects lower pressure parameters during the formation of the latter. The mineral composition of the shales and the low alumina contents in the grotite may indicate the possibility of its crystallization in the rocks of the greenschist facies.
Typochemistry of sulfides of the Ozernoe Au-Pd occurrence (Polar Urals)
Authors: Kondrikova A. , Tyukova E. , Sobolev Ivan , Vikentyev I.
Published: February 2025

The paper presents the first results of local studies of the content and distribution of trace elements in minerals of low-sulfide ores of various associations of the Ozernoe (copper-)gold-palladium occurrence, discovered in 2002 in the Polar Urals and localized in clinopyroxenites and wehrlites of the Middle Paleozoic. According to LA-ICP-MS data, the diversity and concentration levels of trace elements in three associations (pyrrhotite-pyrite, pyrrhotite-chalcopyrite-cubanite and bornite-chalcopyrite) are different. Thus, pyrite of the first association, common on the flanks of the ore zone, is characterized by high concentrations of Co, Se, moderate ones of Ni and traces of Bi, Sb, Ag. The minerals of the pyrrhotite-chalcopyrite-cubanite association, common within the ore zones, commonly contain Ag, Pb and Se, as well as groups of elements (Sb, Bi, Au, Te and Pd), occurring in noticeable amounts, but sporadically, which may be conditioned by microinclusions of their minerals. The highest concentrations of Ag, Se, Te, and Pd are recorded in copper sulfides of the bornite-chalcopyrite association, especially in bornite. The main components of ore and non-metallic minerals (sulfides, Fe-oxides, olivine and pyroxene) has been studied by electron probe microanalysis.
Prospective ameliorants based on industrial wastes of timber enterprises
Authors: Perovskiy I. , Brovarova O. , Shushkov D. , Burcev I. , Veselkov E.
Published: February 2025

As a result of activity of enterprises of the timber industry complex for the production of paper products, significant volumes of secondary mineral raw materials are formed, which need to be utilized. Soil liming is a promising direction of utilization of such raw materials. By methods of X-ray diffraction, X-ray fluorescence and thermal analyses, mass spectrometry with inductively-coupled plasma, radiological studies the material composition of secondary mineral resources of Syktyvkar TP (dust of electric filters of furnaces, slaked lime obtained from substandard calcium oxide, bark and wood ash) has been determined. The determined features of changes in phase and chemical composition of secondary raw materials allowed to develop original compositions of agrochemicals named “Edemit” and “Pushonka plus”, which were tested for soil liming on the experimental field. It was found that liming contributed to the increase of soil pH value from 4.6 to 6.6 on average, the degree of saturation with bases up to 44—92 % and decrease of hydrolytic acidity twice as compared to the control variant.