bluuebunny/crossref_metadata_2025 huggingface dataset:
METHODOLOGICAL PROVISION OF MODERN EVALUATION OF CHARACTERISTICS AND QUALITIES OF INTANGIBLE ASSETS
Authors:   State Institution “Odessa Polytechnic”, Zakharchenko Vitaliy , Metil Tetiana ,   Izmail State University for the Humanities, Ukraine, Oneshko Svitlana ,   Odessa National Maritime University
Published: March 2022

Introduction. The relevance of research on the use of intellectual property rights is determined by: the wavelike dynamics of changes in the number of used intellectual property rights; reducing the number of applications and registered patents for inventions, utility models, marks for goods and services, etc. Certain circumstances require further qualitative research of the essence of intangible assets of industrial innovative enterprises both on the basis of adaptation of international experience and development of own methodological support. The purpose of the article is a methodological support for modern assessment of the characteristics and qualities of intangible assets in enterprises through the analysis of their main content components based on international experience. Research methods. The article used general scientific and special research methods: retrospective and systematic analysis, abstract logical, generalization and comparison; methods of induction and deduction in determining the problem of assessing the characteristics and qualities of intangible assets in enterprises. Results. The article offers an analysis of the essential characteristics and properties of intangible assets of the enterprise, which are combined into the following blocks: intellectual property, copyright, industrial property, business reputation, organizational costs. The basis for the formation of characteristics and properties of intangible assets are the following bases: the absence of material form, the presence of value, value creation, informativeness, and special forms of storage. Intellectual property is, first of all, objects created as a result of creative, intellectual activity of the person. Copyright is regulated by national law and international conventions on copyright protection and is one of the objects of intellectual property. Industrial property is considered as the exclusive right of the patent owner for an invention, industrial design, utility model and the exclusive right of the patent owner for selection achievements. The business reputation of the enterprise as an intangible asset is characterized by the level, value, factors of its formation. Organizational costs are characterized first by the cost of legal registration and registration, and then they are associated with the life cycle of the enterprise. The selected characteristics and properties of intangible assets allow to separate one asset from another, as well as to identify their place, role and methods of application in the economic activity of the enterprise. Conclusions. The above characteristics and features of intangible assets allow you to accurately separate one asset from another, i.e. identify them, and identify their place, role, and means of use in the economic activity of the enterprise, i.e. commercialization and capitalization.
Correlation between malondialdehyde level and FOXO3 and CASP3 mRNA expression changed in early-onset preeclampsia placenta
Authors: Sukanty Ni Made Wiasty , Iswanti Febriana Catur , Dewi Syarifah , Faruqi Muhammad , Andiana Alyssa Shafa , Prijanti Ani Retno
Published: March 2022

Background: Preeclampsia is one of the factors causing the high maternal mortality rate. The risk of morbidity and mortality is higher in Early Onset Preeclampsia (EOPE). Failure of spiral artery remodeling can cause oxidative stress that can inhibit placental development and increase trophoblast apoptosis.

Objective: This study aims to analyze the oxidative stress and apoptosis of EOPE placentas.

Methods: This study is an observational study with a cross-sectional design. A total of 31 EOPE placentas and 31 normal term placentas were used to measure the concentration of malondialdehyde (MDA) and the relative mRNA expression of FOXO3 and CASP3 using the spectrophotometric and RT-qPCR methods.

Results: There was no difference in MDA concentration (p = 0.580) and FOXO3 (p = 0.467) and CASP3 (p = 0.243) mRNA expression in the normal and EOPE groups. There was a strong positive correlation between FOXO3 and CASP3 mRNA expression in the normal (p= 0.0001; r = 0.938) and EOPE groups (p = 0.0001; r = 0.855). There was no correlation between MDA concentration to FOXO3 (p = 0.124; r = 0.282) and CASP3 (p = 0.569; r = 0.106) mRNA expression in normal placenta. There was positive correlation between MDA concentration to FOXO3 (p = 0.016; r = 0.429) and CASP3 mRNA expression in EOPE placenta (p = 0.028; r = 0.395).

Conclusion: These results indicate that cell integrity is still maintained through the autophagy process and the level of apoptosis in the EOPE placenta is regulated by ROS through FOXO3.
Relationship between problematic gaming and emotional intelligence and empathy in early adolescence
Authors: Velki Tena , Milić Marija , Lučić Klara
Published: March 2022

The aim of this study was to determine the relationship between problematic gaming and emotional intelligence and empathy in early adolescence. The study involved N = 143 participants, seventh- and eighth-grade students; n = 76 participants being female. Three instruments were used in the study. E-questionnaire: Emotional Empathy Scale and Imagination Scale, Emotional Skills and Competencies Questionnaire, and Problematic Online Gaming Questionnaire.

The research has revealed that problematic gaming is negatively correlated with emotional intelligence, i.e., that adolescents who score
higher on the online gaming questionnaire have lower levels of emotional intelligence, and vice versa. Furthermore, problematic gaming is negatively associated with adolescent empathy; adolescents who assess
the more frequent presence of behaviors characteristic of problematic gaming have a lower level of empathy, and vice versa. Regarding gender differences, the research showed that, unlike girls, boys are more likely to show behaviors characteristic of problematic gaming, and that the negative association between emotional intelligence and problematic gaming occurs only in boys, while in girls it is absent. The findings of
this research indicate the existence of a negative association between empathy and emotional intelligence and problematic gaming, but it does not determine its direction. Further research is needed to shed light on
the nature of this association. The findings of this research may serve
as a starting point for future more extensive, longitudinal research on
the relationship between problematic gaming and emotional functioning.
Focus groups - main determinants and application possibilities
Authors: Čilić Antea , Lončar Nina
Published: March 2022

A focus group is a 90–120-minute semi-structured conversation between 7-12 participants selected according to some relevant characteristics. The main purpose of the focus group is to determine the attitudes, feelings, beliefs, experiences, and reactions of the participants in a way that is not achievable using other methods.

The paper presents a comprehensive overview of the basic features of the
focus group as a qualitative research method and an analysis of their application with an emphasis on application in education research. The paper, in addition to theoretical analysis by reviewing the relevant
literature, provides a critical review and recommendations for further research on this issue, which contributes to clarifying the purpose and encouraging the application of the focus group method.
Thermophysical properties of biodiesel fuels from modified perturbed hard trimer chain equation of state
Authors: Parvizi Negar , Akbari Falamarz , Alavianmehr Mohammad Mehdi , Mohammad-Aghaie Delara
Published: March 2022

In the present study, a modified version of the perturbed hard trimer chain equation of state was employed to predict thermophysical properties of fatty acid methyl ester (FAME) and fatty acid ethyl ester (FAEE) systems. The thermophysical properties in question are liquid density, vapor pressure, heat capacity, viscosity and thermal conductivity. The predictive power of the model has been assessed by calculating the aforementioned thermophysical properties and comparing with experimental ones as well as other models. Typically, the overall average absolute relative deviation (AARD in %) of the predicted densities for 1665 data points was found to be 2.57%. Simplicity and good agreement between the experimental data and those calculated from the present model, are the reasons for applicability of proposed model with sufficient accuracy for engineering applications. The capability of this new equation of state in predicting both thermodynamic and transport properties simultaneously with good accuracies is really prominent.
Protocolo alternativo com oclacitinib para dermatite atópica canina: Uma solução capaz de reduzir custos?
Authors:   CIISA, Faculdade de Medicina Veterinária, Universidade de Lisboa, Lisboa, Portugal, Bizarro Ana , Martins Anabela ,   CIISA, Faculdade de Medicina Veterinária, Universidade de Lisboa, Lisboa, Portugal, Pinto Marta ,   CIISA, Faculdade de Medicina Veterinária, Universidade de Lisboa, Lisboa, Portugal, Fernandes Beatriz ,   CIISA, Faculdade de Medicina Veterinária, Universidade de Lisboa, Lisboa, Portugal, Pereira Hugo ,   CIISA, Faculdade de Medicina Veterinária, Universidade de Lisboa, Lisboa, Portugal, Braz Berta ,   CIISA, Faculdade de Medicina Veterinária, Universidade de Lisboa, Lisboa, Portugal, Lourenço Ana ,   CIISA, Faculdade de Medicina Veterinária, Universidade de Lisboa, Lisboa, Portugal
Published: March 2022

Introdução: O oclacitinib é um inibidor seletivo da enzima cinase de Janus, que tem como alvo a interleucina-31, sendo utilizado no tratamento da dermatite atópica canina. Apesar de os tutores apresentarem um elevado grau de satisfação com este fármaco, o seu custo representa um foco de preocupação para 75%, sendo que 42,5% dos tutores referiram ter de limitar outras despesas para poderem pagar o tratamento do seu cão. Objetivos: Avaliar a possibilidade de adotar um protocolo alternativo com oclacitinib em dias alternados. Secundariamente, avaliar se existe vantagem em adicionar glucocorticoides orais no início deste protocolo. Métodos: Estudo prospetivo, aleatório, duplamente cego e controlado com placebo, incluindo 16 cães com diagnóstico de dermatite atópica, alocados nos grupos P (n=7; Placebo) e G (n=9; Glucocorticoides). Os animais foram avaliados quanto à gravidade lesional (CADESI-04) e grau de prurido (PVAS) no Dia -30, Dia 0 e end-point (recidiva ou Dia 30). O estudo comportou duas fases distintas e sucessivas. Na primeira fase foi administrado oclacitinib (0,4-0,6 mg/kg, 14 dias, duas vezes por dia [BID], depois 16 dias, uma vez por dia [SID]) por via oral a ambos os grupos. No entanto, nos primeiros 7 dias, ao grupo G foi administrada prednisolona (1mg/kg SID) por via oral e ao grupo P um placebo no mesmo regime. Na segunda fase, todos os animais realizaram o mesmo tratamento, mantendo o oclacitinib, mas apenas em dias alternados, até à recidiva do seu quadro clínico. Resultados: Foi possível adotar o protocolo em dias alternados durante pelo menos 30 dias em 71,43% dos animais. As diferenças encontradas não foram estatisticamente significativas entre as médias de CADESI-04 e grau de prurido dos dois grupos no Dia 0 e no end-point. Também não foram encontradas diferenças entre os períodos de tempo médios sob o tratamento em dias alternados. Conclusões: Existe potencial neste protocolo em dias alternados que permite reduzir os custos mensais para metade, possibilitando um maior acesso a esta ferramenta terapêutica inovadora, segura e muito eficaz, mas também dispendiosa. Não parece existir benefício, em termos de redução da dose de oclacitinib, na introdução de prednisolona no início do tratamento.
Questionário recomendado pelo Grupo Português de Estudos de Urticária (GPEU) para avaliação de doentes com urticária crónica em consulta
Authors:   Serviço de Dermatologia, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal, Gonçalo Margarida ,   Clínica de Dermatologia, Faculdade de Medicina, Universidade de Coimbra, Coimbra, Portugal, Costa Célia ,   Serviço de Imunoalergologia, Hospital de Santa Maria, Centro Hospitalar Universitário de Lisboa Norte (CHULN), Lisboa, Portugal
Published: March 2022

A urticária crónica (UC) é uma doença complexa, multifatorial, com diferentes fenótipos e endótipos, comum na prática clínica e que tem um impacto significativo na qualidade de vida do doente. O diagnóstico é essencialmente clínico. Os exames complementares podem contribuir para despistar fatores etiológicos/de agravamento e/ou comorbilidades, mas são escassos os biomarcadores de diagnóstico e/ou prognóstico e/ou resposta à terapêutica. Assim, na primeira consulta de um doente com UC, o Grupo Português de Estudos de Urticária (GPEU) propõe a realização de um interrogatório sistematizado, uniformizado e que permita identificar parâmetros associados a maior gravidade e que conduzam à otimização da terapêutica ou à orientação de exames complementares de diagnóstico.
O que foi o modernismo e quem o definiu?
Authors: Colón Marcos , Péchy Amanda
Published: March 2022

Narrativa da Semana de 22 como mito fundante do modernismo exclui manifestações culturais da Amazônia. O poeta paulista Menotti del Picchia (1892-1988) foi um dos articuladores, ativistas e colaboradores da Semana de Arte Moderna, marco que completou 100 anos em 2022. O autor abriu a segunda noite – talvez a mais importante e a mais tumultuada – do evento, com uma palestra que negava a filiação do grupo modernista ao futurismo europeu, mas defendia a integração da poesia com os tempos modernos, a liberdade de criação com uma arte genuinamente brasileira.
KEMAMPUAN MANAJERIAL DAN FUNGSI KEPEMIMPINAN KOMANDAN DALAM UPAYA MENINGKATKAN KINERJA GURU DI SEKOLAH BAHASA TNI AL KODIKLATAL SURABAYA
Authors: Supangat Supangat
Published: March 2022

Penelitian ini bertujuan untuk mengetahui apakah faktor kemampuan manajerial guru dan fungsi kepemimpinan Komandan sekolah bahasa TNI AL Kodiklatal di Surabaya yang berorientasi pada hubungan secara bersama-sama (simultan) atau sendiri-sendiri (parsial) mempunyai pengaruh terhadap Kinerja guru di Sekolah bahasa TNI AL Kodiklatal Surabaya. Selain itu diantara Kemampuan manajerial guru dan Fungsi kepemimpinan Komandan sekolah, mana yang mempunyai pengaruh dominan terhadap Kinerja guru. Dengan mengambil sampel 40 guru di lingkungan Sekolah bahasa TNI AL Kodiklatal Surabaya dan  menggunakan metode penelitian deskriptif kuantatif, diketahui bahwa faktor kemampuan manajerial guru dan Fungsi kepemimpinan Komandan sekolah secara bersama-sama berpengaruh signifikan terhadap kinerja guru. Sedangkan secara sendiri-sendiri, Kemapuan manajerial guru berpengaruh signifikan terhadap kinerja guru dan berpengaruh lebih dominan daripada  variabel Fungsi kepemimpinan Komandan sekolah. Fungsi kepemimpinan Komandan sekolah tidak berpengaruh signifikan terhadap kinerja guru. Implikasi hasil penelitian yang penting antara lain perlu mengaplikasikan secara efektif dan optimal terhadap fungsi kepemimpinan Komandan sekolah dan meningkatkan kemampuan manajerial guru melalui training dengan partisipasi aktif setiap guru. Selain itu perlu tindak lanjut penelitian terhadap variabel yang sama.
ASPEK HUKUM SIMPAN PINJAM PADA KOPERASI
Authors: Mutriady Anto
Published: March 2022

Sebagai lembaga keuangan non-bank, koperasi memerlukan serangakaian prosedur yang dapat digunakan untuk mengidentifikasi, mengukur, memantau, dan mengendalikan risiko yang timbul dari kegiatan usaha. Salah satu risiko pada umumnya adalah pembiayaan pada mitra usaha/calon mitra. Untuk menghindari aspek risiko maka koperasi harus menerapkan prinsip kehati-hatian dalam melakukan pembiayaan pada mitra/calon mitra. Prinsip kehati-hatian adalah suatu asas atau prinsip yang menyatakan bahwa dalam menjalankan fungsi dan kegiatan usahanya wajib bersikap hati-hati (prudent) dalam rangkat melindungi dana masyarakat yang dipercayakan kepada koperasi tersebut. Penelitian ini bertujuan untuk mengetahui Regulasi atau aturan hukum dibidang perkoprasian khususnya koperasi sudah mengakomodir penerapan prinsip kehati-hatian dalam peraturan pembiayaan koperasi. Metode yang digunakan dalam penelitian ini adalah metode penelitian normatif empiris dengan metode pendekatan yang digunakan adalah pendekatan Undang-Undang, Pendekatan Sosiologi. Setelah itu melalui beberapa tahapan, maka dapat diketahui bahwa penelitian ini dianalisis dengan deskriptif kualitatif dan penarikan kesimpulan dengan cara induktif. Prinsip koperasi syariah berdasarkan pada Undang-Undang Nomor 17 Tahun 2012 tetang Perkoprasian yaitu bahwa: Koperasi simpan pinjam wajib menerapkan prinsip kehati-hatian, Dalam memberikan pinjaman, koperasi simpan pinjam wajib mempunyai keyakinan atas kemampuan dan kesanggupan peminjam untuk melunasi pinjaman sesuai dengan perjanjian, Dalam memberikan pinjaman, koperasi simpan pinjam wajib menempuh cara yang tidak merugikan keporasi simpan pinjam dan kepentingan penyimpan, Koperasi simpan pinjam wajib menyediakan informasi mengenai kemungkinan timbulnya resiko kerugian terhadap penyimpanan
PENGARUH GAYA HIDUP DAN PENGETAHUAN TERHADAP KEPUTUSAN PEMBELIAN PRODUK RAMAH LINGKUNGAN DI KOTA MEDAN
Authors: Sabrina Hesti , Tarigan Eka Dewi Setia , Nasution Amrin Mulia Utama , Parulian Tohap
Published: March 2022

Peningkatan populasi manusia yang terus berkembang pesat membawa dampak terhadap lingkungan yang memicu pemanasan global, hal ini menyebabkan sebagian besar konsumen yang peduli dengan ekosistem lingkungan berupaya untuk melakukan pembelian produk-produk yang ramah lingkungan guna mendukung keberlanjuan bisnis dan lingkungan yang tetap terpelihara. Penelitian ini dilakukan terhadap 100 orang konsumen di kota Medan yang memiliki perilaku gaya hidup ramah lingkungan dan yang memiliki pengetahuan akan pentingnya perilaku ramah lingkungan yang pernah melakukan pembelian produk ramah lingkungan.
TINJAUAN HUKUM CORPORATE SOCIAL RESPOSIBILITY (CSR) MENURUT UNDANG -UNDANG NO. 40 TAHUN 2007 TENTANG PERSEROAN TERBATAS
Authors: Elisa Nufaris , Rahmadany Rahmadany
Published: March 2022

Perseroan Terbatas dalam menjalankan tugasnya harus berinteraksi dengan berbagai komponen yang terkait dengannya. Secara umum ada dua komponen yang terlibat dalam kegiatan Perseroan Terbatas, dua komponen itu kita kenal dengan shareholder dan stakeholder. Shareholder adalah komponen yang terkait dengan internal Perseroan Terbatas, yang dalam hal ini dikenal dengan para pemegang saham sedangkan yang dimaksud dengan Stakholder adalah semua pihak diluar para pemegang saham yang terkait dengan kegiatan Perseroan Terbatas. Peranan dari komponen stakholder sangat menentukan kelangsungan hidup  perseroan Terbatas. Keberadaan sebuah Perseroan Terbatas di sebuah lingkungan Masyarakat harus mampu memberikan kontribusi positif bagi masyarakat yang bersangkutan. Metode pendekatan yang penulis gunakan dalam penelitian ini adalah pendekatan yuridis normatif dan yuridis empiris. Penelitian ini bersifat deskriptif analitis yang mengungkapkan peraturan perundang-undangan yang berkaitan dengan teori- teori hukum yang menjadi objek penelitian. Hasil penelitian ini menunjukan bahwa manfaat dari Aktivitas Corproate Social Responcibility (CSR) yaitu memperkuat kerekatan sosial bukan hanya tercipta untuk perusahaan sendiri atau masyarakat sendiri, tetapi juga untuk hubungan antara perusahaan dengan masyarakat. Selain masyarakat mendapat manfaat dan perusahaan juga mendapat manfaat hubungan antara keduanya semakin baik, dan ini berimbas pada munculnya bentuk-bentuk kerjasama baru.
ASPEK HUKUM JOINT VENTURE DALAM PENANAMAN MODAL ASING PADA SEKTOR PERINDUSTRIAN DI INDONESIA
Authors: Syafitri Isdiana , Dewi Atika Sandra
Published: March 2022

Modal asing saat ini masih sangat diperlukan guna memacu laju perkembangan ekonomi sebagai modal pelengkap. Namun jika mungkin tidak lagi dibutuhkan dalam bentuk apapun, yakni apabila Indonesia sudah bisa swasembada di bidang permodalan investasi, teknologi, dan manajemen, tetapi dalam kerangka ekonomi global, kerja sama (joint venture) antara lain dunia usaha domestic dan asing akan memainkan peranan yang lebih penting. Hal ini terjadi, meskipun dalam rangka penanaman modal asing pada saat ini, ketentuan joint venture bukanlah bersifat imperative (karena memang Indonesia sangat membutuhkan modal untuk pembangunan ekonomi). Salah satu usaha untuk menghindarkan hambatan-hambatan dalam pelaksanaan joint venture yang dituju, ialah mengadakan pengawasan yang terarah terhadap pelaksanaan rencana pendirian perusahaan setiap pelaksanaan rencana mendirikan suatu usaha joint venture membutuhkan suatu jadwal waktu pelaksanaan serta Checking List dari tahap-tahap serta tugas-tugas yang harus dilaksanakan.
PENGARUH REGULASI DIRI DAN KEBIASAAN BELAJAR TERHADAP HASIL BELAJAR MAHASISWA PRODI AKUNTANSI UNIVERSITAS AMIR HAMZAH MEDAN
Authors: Khairunnida Khairunnida
Published: March 2022

Dalam akuntansi diharapkan mahasiswa memperoleh hasil belajar yang tinggi dan baik.Hasil belajar dipengaruhi oleh beberapa faktor diantaranya regulasi diri dan kebiasaan belajar. Tujuan penelitian ini untuk mengetahui pengaruh regulasi diri dan kebiasaan belajar dapat meningkatkan hasil belajar terutama pada mata kuliah sistem informasi akuntansi mahasiwa program studi akuntansi di Universitas Amir Hamzah Medan.Penelitian menggunakan metode ex post facto. Populasi dan sampel dalam penelitian adalah mahasiswa Program studi akuntansi 2020 A, 2020 B, 2019 A dan 2019 B dengan sampel 118 mahasiwa. Pengambilan data menggunakan kuesioner dan interview.Teknik analisis data menggunakan uji regresi linier berganda dengan berbantuan aplikasi SPSS versi 22. Berdasarkan analisa data, hasil uji t regulasi diri (0,00372 < 0,05) dan kebiasaan belajar (0,000 < 0,05) dan hasil uji F sebesar 29,5074 dengan nilai probabilitas (sig) = 0,000. Hal ini menunjukkan bahwa regulasi diri dan kebiasaan belajar berpengaruh secara simultan terhadap hasil belajar sistem informasi akuntansi mahasiswa Program studi Akuntansi UNHAM. Sedangkan secara parsial tidak berpengaruh terhadap hasil belajar sistem informasi akuntansi  mahasiswa Program studi Akuntansi Universitas Amir Hamzah Medan.
How to Find a Bezier Curve in $\mathbf{E}^{3}$
Authors: ŞENYURT Süleyman , KILIÇOGLU Şeyda
Published: March 2022

"How to find any $n^{th}$ order B\'{e}zier curve if we know its first, second, and third derivatives?" Hence we have examined the way to find the B\'{e}zier curve based on the control points with matrix form, while derivatives are given in $\mathbf{E}^{3}$. Further, we examined the control points of a cubic B\'{e}zier curve with given derivatives as an example. In this study first we have examined how to find any $n^{th}$ order Bezier curve with known its first, second and third derivatives, which are inherently, the $\left( n-1\right) ^{th}$ order, the $\left(n-2\right) ^{th}$ and the $\left( n-3\right) ^{th}$ Bezier curves in respective order. There is a lot of the number of B\'{e}zier curves with known the derivatives with control points. Hence to find a B\'{e}zier curve we have to choose any control point of any derivation\. In this study we have chosen two special points which are the initial point $P_{0}$ and the endpoint $P_{n}$.
Larangan Homoseksual Studi Analisis Tafsir Maqashidi Pada QS. Al-A’raf [7]: 80-81
Authors: Ahmad Murtaza  , Raisa Zuhra Salsabila Awaluddin
Published: March 2022

This article discusses the story of the Prophet Luth QS. Al-A’raf [7]: 80-81 by using the maqashidi interpretation method which was initiated by Abdul Mustaqim. The commentators agree to prohibit homosexual behavior that has been practiced by the people of the Prophet Luth. Although they have various reasonsfor prohibiting it, if you read it as a whole, the opinion of the commentators leads that homosexuality has violated the nature of human beings who live in pairs between women and men. However, using Maqashdi Tafsir is not only limited to prohibiting homosexuals which is limited by the meaning of the text but also results in the meaning behind the QS. Al-A’raf [7]: 80-81 when viewed from the maqashid, namely hifz al-din, hifz nasl, hifz al-‘aql, and hifz nafs, there is no benefit in homosexual behavior except for actions that go beyond the limits and has violated human nature.
Digital Safe Spaces and Self-Definition: Black British Women’s Confessional Vlogs
Authors: lasade-anderson temi
Published: March 2022

Confessional vlogs, where YouTubers reveal incredibly revealing personal details, embody the private-yet-public tension occurring on YouTube. Research has shown that confessional vlogs are dialogical media texts, where the YouTuber engages in self-disclosure and self-expression, building intimacy and community with their audience. This study aims to provide an empirical contribution to the study of YouTube genres, specifically vlogs, by outlining the constitutive elements of confessional vlogs and defining the phenomenon. Building on existing work on the confessional, it asks: how do Black British women articulate their personal and private experiences in confessional vlogs? This mixed-methods study employs critical technocultural discourse analysis to examine YouTube as a technological service, interface, and discourse, making use of a Black feminist theoretical framework. Autoethnography furthers the researcher’s positionality — drawing on her experience, background, and knowledge — weaving data and narrative. Findings indicate that Black British women’s confessional vlogs are monological self-reflexive texts, not dialogical community-building ones. Overall, the analysis found that confessional vlogs are digital ‘safe spaces’ where Black British women self-disclose their complex and dynamic feelings about personal and private experiences, becoming digitally remediated articulations of their self-definition.
Metode Jaya sebagai Penentuan Posisi dan Ukuran Besaran Kapasitas Distributed Generation pada 117 bus
Authors: Mas Baihaqi , Yulyawan Eva Kurnia
Published: March 2022

Penggunaan Metode JAYA ini merupakan usulan pada penelitian yang di lakukan, sebagai pilihan metode untuk optimasi penentuan dimana nantinya Distributed Generation (DG) diletakkan selain penentuan lokasi juga akan di tentukan besarannya juga, pengaplikasian ini dipakai untuk sistem distribusi 20 kV 117 bus dengan saluran sepanjang 59,65 km, bertujuan untuk mengurangi rugi rugi daya juga sebagai penentuan besarnya kapasitas Distributed Generation (DG) yang akan dipasang nantinya. Algoritma ini telah berhasil menentukan besar kapasitas Distributed Generation (DG) dan pada titik dimana posisi paling tepat pada 117 bus di Penyulang Pujon
PELATIHAN DESAIN KEMASAN & PEMOTRETAN PRODUK UNGGULAN KAMPOENG KAJOETANGAN HERITAGE KOTA MALANG
Authors: Bunyamin Bunyamin , Munfaqiroh St , N A Dwi , N U Nunung , - Kadarusman , - Imama Z , - Setyawan , - Ali L , - Triana M , - Fera TJ , Sugeng H  , Nanang P
Published: March 2022

The purpose of this training is to provide insight into new packaging designs and forms that make products more valuable while providing skills for basic product photo mastery so that they can make product photos that can showcase the advantages of their products.In this service, the methods used are lectures, discussions, and questions and answers about packaging design and product photography, training, starting with an introduction to the tools, materials, and media used as well as making product designs and photographing products, as well as by counseling and practice in packaging design and product photography.This activity is very useful in providing knowledge and practice in designing packaging and taking pictures of products as an effort to make consumers more interested in consuming the products of business actors in Kampoeng Kajoetangan, so that they are able to market their products online by displaying product photos that attract consumers to buy their products.
PELATIHAN PEMBUATAN HAND SANITIZER UNTUK MENINGKATKAN KETERAMPILAN BINAAN PANTI ASUHAN YAYASAN SITI FATIMAH PANDAAN
Authors: Windi Zamrudy  , Imron Rosyidi  , Heny Dewajani  , Noor Isnaini Azkiya
Published: March 2022

The Department of Chemical Engineering at the State Polytechnic of Malang in carrying out its function, namely carrying out the Tri Dharma of Higher Education is required to carry out community service through various forms of activity, for this reason, collaboration with the Siti Fatimah Pandaan Orphanage Foundation is carried out. The purpose of this PkM is to provide counseling and understanding of the program which is expected to be a provision for assistants to be independent and can improve students' skills. The PkM program at the Siti Fatimah Pandaan Orphanage Foundation was chosen by considering the efficiency and intensity of program implementation. Aspects of the problems that are resolved in this PkM Program are improving the ability, competence, and understanding of the target audience. This PkM activity consists of several activities, including: 1) Assistance in the manufacture of hand sanitizers, 2) Submission of materials for making hand sanitizers. The results of the PkM showed an increase in participants' knowledge and skills in making hand sanitizers. In addition, increasing understanding of the introduction and application of production management and marketing of hand sanitizers. Furthermore, several PkM achievements that have been achieved include: Articles published in national journals with ISSN, and publication of activities on social media
PELATIHAN KETERAMPILAN HIDUP BERBASIS KEUANGAN BAGI PERANGKAT DESA DUWET KABUPATEN MALANG
Authors: Evelina Tri Yulistyawati , Radhia Jatu Noviarsita Sakti  , Suselo Utoyo  , R. Sugeng Basuki
Published: March 2022

Kualifikasi sumber daya manusia khsususnya perangkat desa merupakan hal penting yang berperan strategis dalam perubahan dan sebagai motor penggerak pembangunan perekonomian desa yang tangguh, sehingga perangkat desa memiliki kemandirian hidup khususnya kemandirian ekonomi.  Sejalan hal tersebut para perangkat desa harus dipersiapkan dengan baik sehingga memiliki pengetahuan, ketrampilan dan sikap kerja yang baik, sehingga mampu bersaing secara global. Peningkatan kapasitas Sumber Daya Manusia dilakukan dengan memberikan pelatihan keterampilan hidup berbasis keuangan untuk meningkatkan produktivitas kerja. Menggunakan modul dari Proyek YouthWin through Economic Participation (YEP Project) yang merupakan bagian dari inisiatif multiprogram bernama Kunci dari United States Agency for International Development (USAID) maka dilaksanakan Pelatihan Keterampilan Hidup berbasis Keuangan yang mengintegrasikan keterampilan Hidup dan Keterampilan Literasi Keuangan yang diharapkan mampu menciptakan sebuah perubahan yang sistemik terhadap persepsi, cara pandang, kepercayaan diri, perilaku serta keterampilan keuangan. Program Ketrampilan Hidup Berbasis Keuangan ini diberikan kepada perangkat desa Duwet terdiri dari perangkat desa peserta perwakilan dari pengelola BUMDesa dan Karangtaruna yang ada di desa Duwet. Pelatihan berjalan sangat lancar dan interaktif karena peserta jarang mendapatkan pelatihan berkenaan dengan Financial Life Skills, dengan metode-metode yang interaktif yaitu: 1) Menarik minat peserta, 2) Role Play; 3) Quiz, 4) Games; 5) Ice Breaking dan energizer.
BUKU KAS BERBASIS WEBSITE PADA USAHA KATERING DI PANTI ASUHAN PUTRI AISYIYAH MALANG
Authors: Dimas Wahyu Wibowo  , Eka Larasati Amalia  , Mentari Mustika , Ahmadi Yuli Ananta  , Muhammad Shulhan Khairy  , Farida Ulfa  , Meuti Zari Annisa  , Ivan Abdurrafie  , Irsyadha Alfyrdhousi Redhysyahputra
Published: March 2022

Community Service, which becomes the main discussion in this article, shows the real role of the world of information technology in helping community service partners. Aisyiyah Putri Orphanage (PAP'A) Malang, as the community service partner, has a catering business and many customers from universities, or hospitals, as well as other communities. The growing number of PAP'A's catering business customers require special handling of the documentation of the expenditure and income, to this point, the recording of the cash book and the preparation of financial reports are still done manually on paper, books or using excel. This has the impact of data inaccuracy due to human error, difficulty in data tracing, or receipts and bills for data recap are sometimes missing and making it difficult to find detailed information about orders in PAP'A catering business. To overcome this problem, developing a website-based cash book to assist and facilitate information on the expenditure and income in PAP'A's catering business is required. Making a web-based digital cash book application can make it easier and make cash flow information and financial reports neater and easier to trace. The partner of this community service activity will benefit from increasing the quality of knowledge and mastery of human resources in the field of digitizing digital ledgers. This will be a provision for the orphanage manager to be able to make income and expenditure reports
BIMBINGAN TEKNIS PENGGUNAAN VACUM FRYING & PENINGKATAN JARINGAN PEMASARAN PADA UMKM PRODUSEN KRIPIK
Authors: Prayitno  , Sri Rulianah  , Achmad Zaini
Published: March 2022

UD. Favoriet is one of the SMEs in Pandaan - Pasuruan which was established in 2008, where this UMKM produces several snack products (Kripik), including: banana chips, meatball chips, crispy cashews & oven cashews, crispy peanuts & oven nuts. These products have been marketed to several areas, including: Pasuruan, Sidoarjo and Malang. However, UD Favoriet in production still operates manually (non-mechanically), does not apply the principles of healthy and good production, as well as the conventional marketing system. At the time of the Covid-19 pandemic, as now, the condition of SMEs experienced a decline in production and sales of up to 60% - 70%. The purpose of PPM Partnership is to increase production capacity, improve product quality, improve a good understanding of production, and increase sales turnover. PPM activities, among others: 1). grant of vacuum frying equipment and sealer, 2). GMP and HACCP training, 3). training in making online marketing media (online marketing). The results of PPM activities include changes in the production system from manual to mechanical, product quality improvement, increased understanding of healthy and safe production methods, and changes in the marketing system from customer to customer to online marketing
PELATIHAN USAHA MINUMAN “KEKINIAN” UNTUK MENINGKATKAN JIWA KEWIRAUSAHAAN SANTRI PPSQ ASY-SYADZILI
Authors: Fathimatus Zahro Fazda Oktavia  , Widi Dwi Ernawati  , Dyah Metha Nur Fitriasih  , Rika Wijayanti  , Rosy Aprieza Puspita Zandra
Published: March 2022

PPSQ Asy-Syadzili as one of the big boarding schools with a total of more than 1,000 students has extraordinary resources if used properly. So far, many resources have not been utilized optimally or are still managed by outsiders. Therefore, this service activity aims to help students take advantage of the internal and external resources and market share of the cottage and make it a place for direct learning how to be a polite and successful entrepreneurship. The concrete steps to be taken are to encourage students to have an entrepreneurial spirit. The business idea taken is a food and beverage business which is the basic needs of the students themselves. Because the activity was carried out during the pandemic, the training was carried out online by uploading tutorial videos on YouTube. The evaluation results after the training showed that participants had a high level of satisfaction, great benefits and the ability of participants to continue the results of the training in starting a business and teaching these skills to other residents. Participants give suggestions so that they can get other training in the future.
PENGUATAN KELUARGA DAN ORANG TUA ASUH PADA KOMUNITAS LEMBAGA HARAPAN UMMAT KECAMATAN LOWOKWARU MALANG
Authors: Fadloli Fadloli , Abdul Chalim  , Widaningsih  , Ahmad Bahauddin Almu’faro  , Mohamad Sinal
Published: March 2022

Harum Institution is a social institution that is engaged in elevating the dignity of marginalized communities in the city of Malang. The purpose of this service activity is to provide spiritual strengthening for families and foster parents who are members of the Harapan Ummat Malang institutional community.

The method of this activity is observation, interviews and about motivation and management of strengthening families and foster parents as well as interactive dialogue to provide solutions to family problems and successful parenting.

The results of this of this service activity provide spiritual services in the form of tausiah and enlightenment and motivation to strengthen families and foster parents at the Harapan ummat Institution. Provide material about future family management in facing challenges, moral decline and difficulties in the economic field, towards a successful family in the hereafter.
PENINGKATAN KEMAMPUAN BAHASA INGGRIS BIDANG PARIWISATA UNTUK GURU SMK PUTIKECWARA BATU
Authors: Mustain Kun , Zubaidi  , Rahayu Eka Listianing , Safitri Isnaini Nur , Lestari Pritantina Yuni
Published: March 2022

This community service aims to accommodate the needs of tourism vocational school teachers in improving English language skills, especially English for hospitality and tourism industry through online English language training. The participants are tourism English teachers at SMK Putikecwara Batu. This activity is expected to improve the quality of learning at the SMK Putikecwara Batu through improving the English language skills of the teachers, which will then be implemented in the classroom and help students improve their English language skills in the tourism sector, especially hospitality and tourism industry. This activity is carried out in four stages, namely planning (to determine the number of participants who will be involved and the materials needed in the training), surveys to schools (to ensure that the plans made are in accordance with the needs), training implementation, and evaluation (giving questionnaires to the participants related to the implementation and training materials).
Hur avgränsas det kommunala ansvaret för att tillgodose äldres behov i kommunala riktlinjer?
Authors: Wittberg Sara , Taghizadeh Larsson Annika
Published: March 2022

Trots att kommunala riktlinjer uppmärksammats som avgörande för hur välfärdens ambitioner för äldreomsorgen tillämpas på lokal nivå genom att vägleda biståndsbedömare i deras bedömningar och beslut så saknas ingående analyser av hur sådana styrdokument är utformade. Syftet med artikeln är att belysa hur det kommunala ansvaret för att tillgodose individuella behov avgränsas i kommunala riktlinjer för biståndsbedömning avseende äldre människor enligt Socialtjänstlagen, liksom hur avgränsningarna underbyggs och legitimeras. Ambitionen är att öka förståelsen för biståndshandläggares arbetsvillkor samt att bidra med underlag för diskussioner om äldreomsorgens styrning. En analys av 51 strategiskt utvalda kommuners riktlinjer har genomförts med stöd i teorin om framing. Analysen visar hur kommuner i riktlinjerna framställs som ansvariga för att tillhandahålla vissa insatser snarare än att, i enlighet med de ambitioner som fanns då SoL infördes, tydliggöra vad som på den lokala nivån är att betrakta som en skälig levnadsnivå när det gäller livsföring i övrigt. Det utrymme som lagen lämnar för lokala anpassningar legitimerar i riktlinjerna istället ett begränsat och specificerat insatsutbud. Begränsningar av det kommunala ansvaret underbyggs och sker även genom såväl korrekt som inkorrekt hänvisning till rättspraxis samt genom att äldres behov av stöd på ett rättsligt tveksamt sätt hänvisas till anhöriga. Riktlinjernas utformning riskerar för det första att – vid tillämpning – ha en negativ inverkan på rättssäkerheten eftersom normerande utbud av insatser är svåra att kombinera med principen om individuell bedömning. För det andra försätter det biståndshandläggarna i en situation där de riskerar att hamna i kläm mellan att följa SoL och lokala föreskrifter då dessa ger motstridiga budskap. För det tredje kan variationer av äldreomsorgens styrning på lokal nivå leda till systematiska skillnader i tillämpningen av lagen. En kartläggning som genomfördes innan artikeln färdigställdes visar att 2019 hade 274 av Sveriges 290 kommuner riktlinjer för biståndsbedömning.
Decellularization of Wharton’s Jelly Increases Its Bioactivity and Antibacterial Properties
Authors: Dubus M. , Scomazzon L. , Chevrier J. , Montanede A. , Baldit A. , Terryn C. , Quilès F. , Thomachot-Schneider C. , Gangloff S. C. , Bouland N. , Gindraux F. , Rammal H. , Mauprivez C. , Kerdjoudj H.
Published: March 2022

The field of regenerative medicine has recently seen an emerging trend toward decellularized extracellular matrix (ECM) as a biological scaffold for stem cell-delivery. Human umbilical cord represents a valuable opportunity from both technical and ethical point of view to obtain allogenic ECM. Herein, we established a protocol, allowing the full removal of cell membranes and nuclei moieties from Wharton’s jelly (WJ) tissue. No alterations in the ECM components (i.e., collagen, GAG content, and growth factors), physical (i.e., porosity and swelling) and mechanical (i.e., linear tensile modulus) properties were noticed following WJ processing. Furthermore, no effect of the tissue processing on macromolecules and growth factors retention was observed, assuring thus a suitable bioactive matrix for cell maintenance upon recellularization. Based on the in vitro and in vivo biodegradability and stromal cell homing capabilities, decellularized WJ could provide an ideal substrate for stromal cells adhesion and colonization. Interestingly, the tissue processing increased the antibacterial and antiadhesive properties of WJ against Staphylococcus aureus and Staphylococcus epidermidis pathogens. Altogether, our results indicate that decellularized WJ matrix is able to limit Staphylococcus-related infections and to promote stromal cell homing, thus offering a versatile scaffold for tissue regenerative medicine.
Digital Transformation of Concrete Technology—A Review
Authors: Gamil Yaser , Cwirzen Andrzej
Published: March 2022

Digital transformation of concrete technology is one of the current “hot topics” tackled by both academia and industry. The final goal is to fully integrate the already existing advanced concrete technologies with novel sensors, virtual reality, or Internet of things to create self-learning and highly automated platforms controlling design, production, and long-term usage and maintenance of concrete and concrete structures. The digital transformation should ultimately enhance sustainability, elongate service life, and increase technological and cost efficiencies. This review article focuses on up-to-date developments. It explores current pathways and directions seen in research and industrial practices. It indicates benefits, challenges, and possible opportunities related to the digital transformation of concrete technology.
Uncovering Pharmacological Opportunities for Cancer Stem Cells—A Systems Biology View
Authors: Correia Cristina , Weiskittel Taylor M , Ung Choong Yong , Villasboas Bisneto Jose C , Billadeau Daniel D , Kaufmann Scott H , Li Hu
Published: March 2022

Cancer stem cells (CSCs) represent a small fraction of the total cancer cell population, yet they are thought to drive disease propagation, therapy resistance and relapse. Like healthy stem cells, CSCs possess the ability to self-renew and differentiate. These stemness phenotypes of CSCs rely on multiple molecular cues, including signaling pathways (for example, WNT, Notch and Hedgehog), cell surface molecules that interact with cellular niche components, and microenvironmental interactions with immune cells. Despite the importance of understanding CSC biology, our knowledge of how neighboring immune and tumor cell populations collectively shape CSC stemness is incomplete. Here, we provide a systems biology perspective on the crucial roles of cellular population identification and dissection of cell regulatory states. By reviewing state-of-the-art single-cell technologies, we show how innovative systems-based analysis enables a deeper understanding of the stemness of the tumor niche and the influence of intratumoral cancer cell and immune cell compositions. We also summarize strategies for refining CSC systems biology, and the potential role of this approach in the development of improved anticancer treatments. Because CSCs are amenable to cellular transitions, we envision how systems pharmacology can become a major engine for discovery of novel targets and drug candidates that can modulate state transitions for tumor cell reprogramming. Our aim is to provide deeper insights into cancer stemness from a systems perspective. We believe this approach has great potential to guide the development of more effective personalized cancer therapies that can prevent CSC-mediated relapse.
Fenofibrate Increases the Population of Non-Classical Monocytes in Asymptomatic Chagas Disease Patients and Modulates Inflammatory Cytokines in PBMC
Authors: Pieralisi Azul V. , Cevey Ágata C. , Penas Federico N. , Prado Nilda , Mori Ana , Gili Mónica , Mirkin Gerardo A. , Gagliardi Juan , Goren Nora B.
Published: March 2022

Chronic Chagas disease cardiomyopathy (CCC) is the most important clinical manifestation of infection with Trypanosma cruzi (T. cruzi) due to its frequency and effects on morbidity and mortality. Peripheral blood mononuclear cells (PBMC) infiltrate the tissue and differentiate into inflammatory macrophages. Advances in pathophysiology show that myeloid cell subpopulations contribute to cardiac homeostasis, emerging as possible therapeutic targets. We previously demonstrated that fenofibrate, PPARα agonist, controls inflammation, prevents fibrosis and improves cardiac function in a murine infection model. In this work we investigated the spontaneous release of inflammatory cytokines and chemokines, changes in the frequencies of monocyte subsets, and fenofibrate effects on PBMC of seropositive patients with different clinical stages of Chagas disease. The results show that PBMC from Chagas disease patients display higher levels of IL-12, TGF-β, IL-6, MCP1, and CCR2 than cells from uninfected individuals (HI), irrespectively of the clinical stage, asymptomatic (Asy) or with Chagas heart disease (CHD). Fenofibrate reduces the levels of pro-inflammatory mediators and CCR2 in both Asy and CHD patients. We found that CHD patients display a significantly higher percentage of classical monocytes in comparison with Asy patients and HI. Besides, Asy patients have a significantly higher percentage of non-classical monocytes than CHD patients or HI. However, no difference in the intermediate monocyte subpopulation was found between groups. Moreover, monocytes from Asy or CHD patients exhibit different responses upon stimulation in vitro with T. cruzi lysates and fenofibrate treatment. Stimulation with T. cruzi significantly increases the percentage of classical monocytes in the Asy group whereas the percentage of intermediate monocytes decreases. Besides, there are no changes in their frequencies in CHD or HI. Notably, stimulation with T. cruzi did not modify the frequency of the non-classical monocytes subpopulation in any of the groups studied. Moreover, fenofibrate treatment of T. cruzi-stimulated cells, increased the frequency of the non-classical subpopulation in Asy patients. Interestingly, fenofibrate restores CCR2 levels but does not modify HLA-DR expression in any groups. In conclusion, our results emphasize a potential role for fenofibrate as a modulator of monocyte subpopulations towards an anti-inflammatory and healing profile in different stages of chronic Chagas disease.