bluuebunny/crossref_metadata_2025 huggingface dataset:
Prediksi Kuota Pemesanan Bahan Bakar Pada SPBU dengan Metode Regresi Linear Berganda
Authors: Abdurrasyid Abdurrasyid , Indrianto Indrianto , Susanti Meilia Nur Indah
Published: October 2021

Bahan bakar minyak menjadi komoditi penting dalam menjalankan roda perekonomian suatu negara, data Badan Pengatur Hilir Minyak dan Gas(BPH MIGAS) mencatat Indonesia menghabiskan 28,25 juta kiloliter selama tahun 2019, angka ini dihimpun dari seluruh Stasiun Pengisian Bahan Bakar Umum (SPBU) yang menjadi hilir distribusi BBM kepada masyarakat, namun disisi lain SPBU sering kehabisan stok karna kurangnya pengendalian terhadap stok, dampaknya adalah antrian panjang masyarakat di SPBU, bagi SPBU yang kehabisan stok jelas akan mengurangi pemasukan karna delay tidak ada penjualan selama proses pengiriman dari hulu ke hilir, maka dibutuhkan adanya sistem yang mampu membantu memprediksi berapa kuota yang harus dipesan sehingga kondisi out of stock tidak terjadi, untuk melakukan peramalan kuota bahan bakar digunakan metode regresi linier berganda yang terdiri dari variabel independent stok sisa (X1), stok masuk (X2) dan variabel dependent stok keluar (Y). Setelah dilakukan uji asumsi klasik dapat disimpulkan bahwa variabel independent (X1 dan X2) berpengaruh positif terhadap variabel dependent (Y). Dari hasil pengujian tingkat error menggunakan metode MAPE (Mean Absolute Percent Error) diperoleh tingkat error untuk peramalan pertalite selama seminggu sebesar 11,0% dan untuk tingkat error peramalan solar sebesar 13,2%.
Perbandingan Pre-trained Word Embedding dan Embedding Layer untuk Named-Entity Recognition Bahasa Indonesia
Authors: Susanty Meredita , Sukardi Sahrul
Published: October 2021

Named-Entity Recognition (NER) is used to extract information from text by identifying entities such as the name of the person, organization, location, time, and other entities. Recently, machine learning approaches, particularly deep-learning, are widely used to recognize patterns of entities in sentences. Embedding, a process to convert text data into a number or vector of numbers, translates high dimensional vectors into relatively low-dimensional space. Embeddings make it easier to do machine learning on large inputs like sparse vectors representing words. The embedding process can be performed using the supervised learning method, which requires a large number of labeled data sets or an unsupervised learning approach. This study compares the two embedding methods; trainable embedding layer (supervised learning) and pre-trained word embedding (unsupervised learning).  The trainable embedding layer uses the embedding layer provided by the Keras library while pre-trained word embedding uses word2vec, GloVe, and fastText to build NER using the BiLSTM architecture. The results show that GloVe had better performance than other embedding techniques with a micro average f1 score of 76.48.
Sistem Pendukung Keputusan Penentu Penerima Reward Guru Dengan Metode Weighted Product (WP)
Authors: Warnars Harco Leslie Hendric Spits , Adyana Lukman
Published: October 2021

Sumber Daya Manusia (SDM) sangat memberikan peran penting dalam menjalankan sebuah organisasi ataupun instansi maupun sebuah negeri, Institusi pendidikan formal mengenban peran penting sebagai ujung tombak untuk menghasilkan output berupa sumber daya manusia yang bermutu dan berkarakter di masa mendatang. SMKN 1 Kragilan adalah salah satu Sekolah Menengah Kejuruan yang berusaha meningkatkan mutu dan kualitas kinerja Guru. Untuk mewujudkan SDM yang berkualitas, perlu adanya penerapan sistem berupa pemberian reward untuk Guru. Akan tetapi, penilaian kinerja guru diterapkan belum tersistemkan, sehingga penilaian kinerja menjadi tidak efektif dan efisien. Maka diperlukan sistem untuk penilaian kinerja Guru dalam pengambilan keputusan penentu penerima reward guru  yang dapat menyajikan informasi dalam pengambilan keputusan. Metode Weighted Product (WP) ialah salah satu dari banyak metode yang diimplementasi dalam sebuah Sistem Pendukung Keputusan (SPK) yang diterapkan dalam berbagai algoritma pemecahan masalah.
Rancang Bangun Sistem Monitoring Pada Bendungan Dengan Menggunakan Metode Fuzzy Tahani Berbasis Mikrokontroler
Authors: Sikumbang Hengki , Indrianto Indrianto , Siregar Garang Syahputra
Published: October 2021

This research designed a monitoring system on dam by using fuzzy tahani method based on Microcontroller. This tool is designed to be used as monitoring on the Katulampa Dam. This tool consists of Raspberry module Pi 3 model B, ultrasonic sensors, resistors and android. The monitoring system on the dam is used to inform the user/citizen when the water in the dam has exceeded the specified height limit and notify the user of the appliance if there is a possibility of flooding, so that residents around the dam can be alert and avoid danger caused by flood . So that with the tool is expected to provide solutions to residents around the dam and residents whose homes are near the dam river flow in case of sudden danger or flood within 24 hours in real time and can minimize casualties due to flooding. By using application module on android that can give notification sms to appliance user and citizen, hence citizen around the dam will be more secure and protected from danger caused by flood and can minimize victim or other loss caused by flood.
Pengembangan Lampu Jalan Umum Dengan Listrik Tenaga Surya Di Desa Cilatak Kecamatan Ciomas Kabupaten Serang Banten
Authors: MAKKULAU ANDI , Mauriraya Kartika Tresya , Afrianda Rio , Pasra Nurmiati
Published: October 2021

Photovoltaic systems or solar power plants  convert electromagnetic energy from sunlight into electrical energy. This renewable energy based power plant is one of the recommended solutions for electricity in remote rural areas where sunlight is abundant and fuel is difficult to obtain and relatively expensive. The Ministry of Energy and Mineral Resources has issued Ministerial Regulation regarding the use of the Roof Solar Power Plant  system by consumers of the Indonesian Electricity Company (PLN). It is hoped that with this regulation the solar panel business and industry can flourish. The method we use in this Community Service is the observation method. By making observations in the field accompanied by interviews with the surrounding population becomes our primary data source in determining the needs of the problems that occur. In Cilatak Village we found minimal of street lighting, and limited electricity supply, for this reason we strongly support programs for new and renewable energy for remote areas that are difficult to get electricity supply. Based on this, we created the Development of Public Street Lights with Solar Electricity in Cilatak Village, Ciomas District, Serang District, Banten, so that the problems of public road lighting can be overcome, and we educated the utilization and maintenance.
Sosialisasi Pemasangan, Pengoperasian Dan Pemeliharaan Panel Surya Fotovoltaik Di Pondok Pesantren Khoiru Ummah, Sumedang
Authors: Yogianto A Agus
Published: October 2021

Penggunaan panel fotovoltaik/PV sebagai pembangkit listrik skala rumah tangga relatif masih terbatas jumlahnya, tetapi diperkirakan akan semakin meningkat di masa mendatang. Disisi lain pengetahuan dan pemahaman terhadap teknologi pengoperasian panel surya PV di pihak masayarakat masih sangat terbatas, sehingga dapat berpengaruh terhadap optimalisasi penggunaan dan pemanfaatan panel PV sebagai pembangkit listrik. Berdasarkan hal ini maka tim Pengabdian kepada Masyarakat/PkM Institut Teknologi PLN mengambil topik yaitu sosialisasi pemasangan, pengoperasian dan pemeliharaan panel surya sebagai pembangkit listrik untuk disampaikan kepada mitra Institut Teknologi PLN yaitu STP/SMP-SMA Pondok Pesantren  Khoiru Ummah, Kecamatan Tanjung Sari, Kabupaten Sumedang, Jawa Barat.

Sosialiasasi ini bertujuan agar para peserta yang terdiri dari siswa dan pengajar sebagai bagian dari masyarakat Indonesia dapat memiliki pengetahuan dan ketrampilan praktis yang berkaitan dengan pemasangan, operasi, dan pemeliharaan panel PV serta perangkatnya. Kegiatan PkM diawali dengan perencanaan, persiapan perangkat, penyusunan prosedur/bahan sosialisasi dan realisasi pelaksanaan sosialisasi. Dari sosialisasi yang sudah dilaksanakan di awal Juli 2020, dapat diketahui bahwa para peserta membutuhkan sosialisasi ini. Berdasarkan diskusi awal dan setelah diberikan sosialisasi dapat diketahui bahwa kegiatan PkM ini bermanfaat untuk meningkatkan pengetahuan dan pemahaman terhadap energi terbarukan untuk pembangkitan tenaga listrik.
Pemanfaatan Lahan Pekarangan Untuk Meningkatkan Ekonomi Warga RT 002/05 BTN Cantiga Petir Cipondoh Tangerang
Authors: Darmana Tasdik
Published: October 2021

Keterbatasan lahan untuk pekarangan serta lingkungan pemukiman padat merupakan permasalahan yang terjadi di perkotaan. Hal ini mengakibatkan lingkungan menjadi kumuh dan dapat menimbulkan berbagai macam penyakit. Salah satu upaya yang dilakukan dalam kegiatan Pengabdian Kepada Masyarakat yang dilakukan oleh dosen bersama mahasiswa bagi masyarakat di RT 002/05 Komplek BTN Cantiga Petir Cipondoh Tangerang adalah untuk mengoptimalkan lahan yang kurang produktif dan tidak terurusmenjadi bermanfaat bagi warga sekitarnya dengan melakukan teknik aquaponik yang merupakan alternatif tepat dan sesuai untuk budi daya tanaman sayuran, buah-buahan dan beternak ikan pada lahan pekarangan sempit, serta dapat dijadikan salah satu upaya agar masyarakat tertarik dengan teknik aquaponik yang mudah dan murah sekaligus dalam upaya untuk membuat lingkungan sekitarnya menjadi lebih asri. Dengan telah dilaksanakannya kegiatan ini, memberi dampak positif bagi warga, terutama ibu-ibu, orang tua dan pensiunan karena sebagai bagian dari kegiatan rekreasi yang bermanfaat dan produktif.
Pelatihan Robot Line Follower Di Pesantren Asshiddiqiyah 2 Batu Ceper
Authors: Junaidi Andi
Published: October 2021

Ilmu pengetahuan dibidang teknologi dan informasi terus berkembang pesat belakangan ini. Salah satunya adalah dibidang robotic system. Di Indonesia sendiri khususnya pondok pesantren sangat sedikit memasukkan matapelajaran atau kegiatan ekstrakulikuler tentang robotik ini baik di tingkat SMA maupun SMK. Hal ini bisa dikarenakan belum diarahkan dan diberi kebijakan dari kementrian Pendidikan untuk diberikan pelajaran robotik dasar. Pondok Pesantren Asshiddiqiyah 2 Batuceper Tangerang merupakan salah satu pesantren yang selama ini konsisten memberikan Pendidikan dan melalui pengabdian masyarakat ini para santri diharapkan mendapatkan pelatihan dan pengalaman guna menunjang ilmu yang baru dibidang teknologi salah satunya adalah pelatihan robot dasar. Dimana jenis robot yang akan kita gunakan adalah robot line follower. Luaran yang diharapkan dalam kegiatan pengabdian ini adalah pemahaman tentang robotic system dan lomba robot line follower sebagai tolok ukur hasil pelatihan untuk santri SMA Manba’ul ulum Asshiddiqiyah 2.
Penetration Testing pada Website Universitas ARS Menggunakan Open Web Application Security Project (OWASP)
Authors: Hidayatulloh Syarif , Saptadiaji Desky
Published: October 2021

Universitas ARS adalah perguruan tinggi yang memanfaatkan website dalam melakukan kegiatan perkuliahannya. Seluruh informasi yang berkaitan dengan perkuliahan dimuat di website Universitas ARS. Banyak resiko yang akan terjadi apabila web server yang digunakan oleh website Universitas ARS tidak memiliki keamanan yang baik, banyak ancaman dari pihak yang tidak bertanggung jawab memanfaatkan celah keamanan untuk merugikan Universitas ARS. Tujuan penelitian ini adalah melakukan identifikasi kerentanan yang terdapat dalam website Universitas ARS dan melakukan pengujian serta analisis untuk mengetahui kondisi kerentanan website Universitas ARS menggunakan OWASP. Metode penelitian yang digunakan sebagai parameter keamanan website adalah OWASP Top-10 2017. Jumlah subdomain yang diuji adalah 5 subdomain yang teridentifikasi dengan melakukan scanning menggunakan tool TheHarvester diantaranya adalah https://universitas.ars.ac.id, http://mahasiswa.ars.ac.id, https://pmb.ars.ac.id, https://beasiswa.ars.ac.id, dan http://ejurnal.ars.ac.id. Hasil dari penelitian ini adalah ditemukannya kerentanan website Universitas ARS yang berhasil dipindai adalah 13 kerentanan. Dari 13 kerentanan tersebut ada 1 kerentanan yang berada pada tingkat ancaman yang sedang dan 12 berada pada tingkat ancaman yang rendah.   Berdasarkan seluruh pengujian kerentanan yang dilakukan dapat disimpulkan bahwa website Universitas ARS memiliki keamanan yang sangat baik, memenuhi ketiga aspek keamanan informasi, memiliki web server dan software sistem informasi akademik yang aman.
Sistem Informasi Akademik Santri Berbasis Web di Pondok Pesantren
Authors: Sutedi Ade , Septiana Yosep , Abdul Halim Rifki
Published: October 2021

Pondok pesantren merupakan institusi pendidikan nonformal dengan tujuan mengkaji, menafsirkan, menggali, menjiwai, dan mengaplikasikan ajaran islam dengan menegaskan pentingnya etika agama sebagai pedoman perilaku sehari-hari. Sistem Informasi Akademik Santri dibutuhkan untuk memudahkan orang tua santri dan pengurus pondok pesantren karena terdapat permasalahan, Pondok Pesantren masih menggunakan sistem yang konvensional dalam hal informasi akademiknya, dan sulitnya melakukan pembayaran dan pemberian informasi kepada orang tua santri dimasa pandemi seperti ini, sehingga dirancang sistem informasi akademik santri yang dipadukan dengan sistem pembayaran. Dengan adanya Sistem Informasi Akademik Santri ini dapat mengefisienkan pekerjaan, yang dimana sebelum adanya sistem informasi akademik santri ini proses bisnis yang berjalan masih menggunakan cara yang konvensional. Penelitian ini bertujuan Merancang Sistem Informasi Akademik Santri di Pondok Pesantren. Metodologi yang digunakan yaitu Rational Unified Process, dengan menggunakan empat tahapan yaitu inception, elaboration, construction, dan transition dengan menggunakan pemodelan Unified Modelling Language, serta menggunakan metode pengujian blackbox testing. Produk riset ini yaitu terciptanya Sistem Informasi Akademik Santri Berbasis Web. Adapun kontribusi riset ini yaitu sistem informasi ini dapat membantu masyarakat terkhusus orang tua santri dalam melakukan pencarian informasi akademik santri di pondok pesantren AL Halim Garut, Selain itu Sistem Informasi ini sebagai media pondok pesantren Al Halim Garut ke masyarakat luas, sehinga dihrapkan pondok pesantren Al Halim Garut dapat menjadi bahan percontohan pondok pesantren yang lain.
Joyería artesanal en oro. Producción más limpia
Authors: Landazábal Sanmiguel Laura Lucía , Rodríguez Acuña Alejandra , Meneses Santa Juliana , Restrepo Pedrosa María Camila
Published: October 2021

Este artículo tiene como propósito presentar los aspectos y/o impactos de la cadena de producción de la joyería en oro por medio de una indagación y revisión bibliográfica de los procesos productivos en talleres colombianos de joyería artesanal, entendiendo la joyería artesanal como aquel arte elaborado por artesano y orfebres donde su principal materia prima es el oro. El estudio comprende la cadena de producción desde la extracción de los metales hasta la fabricación de los productos, documentando las consecuencias ambientales causadas por la misma cadena enlas últimas dos décadas.
Avant-garde artists at the Kharkiv Art School: Vasyl Yermilov and Boris Kosarev
Authors:   Kharkiv State Academy of Design and Arts, Pavlova Tetiana
Published: October 2021

The article deals with the formation of avant-garde as an alternative to the academic artistic paradigm in the Kharkiv Art School. The contribution of Kharkiv artists to the world culture is determined primarily by the avant-garde art. Its agents, who steadily carried the baton of modernization of artistic culture, were V. Yermilov and B. Kosarev. During 1915–1916 a group of artists, The Union of Seven, was formed at the Art School; their work reflected the diverse palette of changes that accompanied the formation of Cubo-Futurism in Kharkiv. Fundamental changes took place in the artistic culture of Ukraine in the 1920s. The initiative to transform Kharkiv Art School into an Art Technical School with the rights of an institution of higher education in 1921, is attributed to Yermilov (it actually became an institute in 1927). In the 1920s–1930s his teaching team was joined by such artists as Mykola Burachek, Ivan Padalka, Oleksander Khvostenko-Khvostov, Anatol Petrytsky, and Borys Kosarev. Studios were established: easel painting (Mykhailo Sharonov), monumental (Lev Kramarenko), and theatrical (Oleksander Khvostenko-Khvostov). From 1922 to 1934 Yermilov led the graphics studio (together with Padalka starting in 1925). The key figures in the creation process of artistic avant-garde culture in Kharkiv after the 1930s were V. Yermilov and B. Kosarev, who influenced the formation of the next generation of artists. Yermilov’s work in Kharkiv (including teaching at Art Institute) had an impact on the creative features of O. Shcheglov, V. Platonov, V. Savenkov, and defined the horizon of effective development of design in the region. Among those who continued Yermilov’s design traditions are M. Molochynsky, І. Krivoruchko, V. Lesnyak, O. Bojchuk, V. Danilenko, O. Veklenko. Launched by the latter International Environmental Forum of Eco Poster “The 4th Block” has found quite a resonance in the world. “Yermilov’s Mansard” appeared on Kharkiv cultural space as an artistic centre and an original example of artistic design in the spirit of Bauhaus. Due to B. Kosarev a constellation of talented artists appeared in Kharkiv artistic culture and defined its uniqueness. Among his students in the theatre and decorative department there were such people as a teacher Konstantinov; a theater artist, a Doctor of Architecture, corresponding member of the AAU V. Kravetz; the Main artist of Kharkiv State Academic Ukrainian Drama Theater named after T. Shevchenko T. Medvid; theatre artists M. Kuzheliev, G. Nesterovska, P. Osnachuk, L. Pisarenko, N. Rudenko-Krayevska and others. Among the artists, whose creative work shaped under the influence of B. Kosarev, were Honoured Artist of Ukraine, member and Vice President of AAU V. Sidorenko, and Honored Artist of Ukraine, famous graphic N. Myronenko.
Hryhoriy Bondarenko and His School.
Authors:   Kharkiv National University of Civil Engineering and Architecture, Shylo Oleksandr
Published: October 2021

Through his work and pedagogical activity, an outstanding Kharkiv graphic artist, professor of Kharkiv Art Institute Hryhoriy Bondarenko connected today’s artistic practice with the great traditions of art, to which he belonged. In the 1910s, H. Bondarenko studied at the Odessa Art School, with K. Kostandi; in 1915–1917 – at the Academy of Arts; and in 1923–1927 at Leningrad VKhUTEIN with K. S. Petrov-Vodkin and V. M. Konashevich. A chain of artistic tradition was formed in VKhUTEIN: K. Petrov-Vodkin – V. Serov – I. Repin – P. Chistyakov. With his pedagogical activity Chistyakov poses the problem of the creative method, and Repin – of the art form. Serov approaches its solution in the idea of projection drawing. Petrov-Vodkin supplemented it with an understanding of picture plane as space. Bondarenko synthesized all these aspects. His creative method is considered on the example of a number of his graphic works. It is based on three main points. The first is a double understanding of the picture plane on which the image is made. It is thought of, on the one hand, as a projection plane and, on the other hand, as space. The second is a combination of projections. The third is the understanding of the image as a way of processing the surface of the sheet. Among the students of H. Bondarenko, perceived this creative method, there were such well-known masters as V. Kulikov, V. Lenchin, V. Nenado. Each of them developed those aspects of the method that were organic to them. The universality, harmony and consistency of the analyzed creative method are shown in the article. It is based on a holistic worldview. Two great traditions, the successor, contemporary and continuer of which he was, merged together in H. Bondarenko’s creative activity and pedagogical work: the classical art of the 19th century, and new art of the 20th century, which itself has become a new classic and a new tradition.
Based on the Experience of Cooperation of the Kharkiv State Academy of Design and Arts with Cherkasy State Technological University: Twenty Years of Experience
Authors:   Cherkasy State Technological University, Romanenko Nataliya
Published: October 2021

The article considers and analyzes the historical events of the twenty-year cooperation of the Kharkiv State Academy of Design and Arts with Cherkasy State Technological University. Practically all stages of formation of the Cherkasy School of Design in ChSTU are connected with the Kharkiv State Academy of Design and Arts (KSADA): starting with the Agreement between Cherkasy Engineering and Technological Institute (ChETI) and Kharkiv Art and Industrial Institute on the establishment of a general technical faculty – in 1999 year, the creation of the Department of Design in 2002, the first graduation of bachelors in 2005, specialists – in 2007 and masters – in 2009, holding regional, national and international conferences in 2008, 2010, 2017, respectively. They are years of not only fruitful cooperation, but of constant gaining experience of teachers, associate professors and professors of the Department of Design of ChSTU on educational, methodical and scientific work in KSADA. Constant involvement of leading specialists of KSADA in educational and methodical work: conducting entrance examinations of the first set of students-designers, teaching professional disciplines, management of diploma projects, chairing of state examination commissions on defence of diploma projects of bachelors, specialists and masters. Separately, the author draws the reader’s attention to the essential role of KSADA in the training of scientific personnel. Postgraduate studies, doctoral studies, systematic work of the specialized council K 64.109.01 became the launching pad for dozens of candidates of art history of Ukraine. 57% of the teaching staff of the Department of Design of ChSTU, who have a scientific degree, were engaged in postgraduate studies or defended a PhD degree at KSADA. The experience of cooperation at the modern level demonstrates the benefits of cooperation of related schools not only for the development of regional design centres, but also the methodology of design education in Ukraine in general.
Architectural Style as a Symbol of Hudprom: The History of Battles of a Hundred Years Ago
Authors:   Kharkiv State Academy of Design and Arts, Rosenfeld Maxim
Published: October 2021

The article deals with the problems of finding a national style in architecture in the early twentieth century. The issues of the main polemical aspects of the choice of artistic language as an expression of the artistic direction of the institution, the influence of the stylistic decision on the symbolism of the content of the institution are considered. The events that preceded the construction: competitions, discussions, confrontations of political opponents formed a very relevant discussion in search of an authentic form that would express the Ukrainian spirit. This is what created a clear image of the building, which is an association and a business card with Hudprom
The Poetics of the Ukrainian Font and Graphic Image of HUDPROM: A 100-year Search
Authors:   Kharkiv State Academy of Design and Arts, Chekal Oleksii
Published: October 2021

The article deals with the search for a graphic style for the Kharkiv Art School for the 100th anniversary of HUDPROM. Based on a study of the Ukrainian font tradition, a visual image was found that links different generations of Kharkiv artist. It shows how the bridge between the Kubo-futuristic finds of the Kharkiv art-craftsmen Vasyl Yermilov, Boris Kosarev and modern design thinking was stretched in the development of inscriptions and signs. The features of working with typographic and aesthetic clusters to reveal the identity of time and place in graphic design are described. A variable font has been developed, combining both grotesque and avant-garde forms and more plastic historical graphemes based on cursive heritage. The flower of Kosarev, which has become a graphic image of the academy, simultaneously in different contexts and compositional solutions embodies the flourishing Ukrainian modernism (historical background), as well as represents the modern multimedia postmodernist pattern.
The Symbolic Journey of E. Pavlov’s “Violin” from the Actual World to the Virtual and Back
Authors:   Non-governmental organization ‘Cultural Activities Promotion Institute’, Chekh Natalia
Published: October 2021

Pavlov, Ye. & Pavlova, T. (2018). Violin. Kyiv: Rodovid. [In Russian & English].
PROFIL SUHU DAN SALINITAS SECARA VERTIKAL DI PERAIRAN TELUK KENDARI
Authors: Saputri Fera Meilani , Asmadin . , Takwir Amadhan
Published: October 2021

Suhu dan salinitas merupakan salah satu faktor oseanografi yang berperan penting dalam mempelajari kondisi suatu peraira. Penelitian ini bertujuan untuk mengetahui profil suhu dan salinitas secara vertikal di Perairan Teluk Kendari. Penelitian mengunakan Metode yang digunakan dalam penelitian ini adalah mengunakan metode survey yaitu dengan melakukan pengukuran, pengambilan, dan  pengamatan terhadap sampel secara langsung di lapangan.  Mengunakan data primer dan sekunder meliputi data pasang surut, suhu dan salinitas. Profil vertikal suhu di Perairan Teluk Kendari memiliki nilai suhu tertinggi pada saat pasang dan surut berada pada kedalaman 0-2 m tepatnya pada muara sungai dan tengah teluk dengan nilai suhu  yang dihasilkan 31-33 OC. Nilai suhu terendah berada pada kedalaman 7-10 m dengan  nilai suhu yang dihasilkan 29-31 OC tepatnya pada mulut teluk dan tengah teluk. Profil vertikal salinitas di Perairan Teluk Kendari memilki nilai salinitas tertinggi pada saat pasang dan surut berada pada kedalaman 3-10 m dengan nilai salinitas yang dihasilkan 31-33 ppt tepatnya pada tengah teluk dan mulut teluk, nilai salinitas terendah berada pada kedalaman 0-6 m dengan nilai salinitas mencapai 19-30 ppt tepatnya pada bagian tengah teluk.Kata kunci: Suhu, Salinitas, Pasang Surut, Teluk Kendari
DISTRIBUSI DAN KEANEKARAGAMAN ASCIDIACEA DI PULAU HOGA BAGIAN BARAT PERAIRAN TAMAN NASIONAL WAKATOBI SULAWESI TENGGARA
Authors: Junawir . , Palupi Ratna Diyah , Rahmadani .
Published: October 2021

Ascidiacea diketahui memiliki berbagai manfaat, secara ekologi maupun ekonomis, Ascidiacea berperan dalam pengendalian fitoplankton dan dapat mengurangi eutrofikasi dan konsentrasi kontaminan juga dapat dimanfaatkan sebagai bahan pangan dan bahan obat-obatan. Penelitian ini dilakukan bertujuan untuk mengetahui keanekaragaman hayati Ascidiacea, kepadatan, distribusi jenis dan preferensi substrat yang ditempati Ascidiacea di Pulau Hoga. Metode pengambilan data yang digunakan adalah line intercept transect untuk pengambilan data tutupan terumbu karang dan pengamatan langsung sepanjang transek sabuk dengan luas 100 m² untuk pangamatan Ascidiacea. Transek dipasang sejajar dengan garis pantai dan pada setiap zona terumbu karang dan dilakukan 2 ulangan sebanyak 3 stasiun penelitian. Hasil dari penelitian keanekaragaman Ascidiacea ditemukan 4 famili terdiri dari 9 jenis yaitu Atriolum robustum, Clavelina sp., Didemnum molle, Lissoclinum patella, Polycarpa aurata, Polycarpa sp 1, Polycarpa sp 2, Rhopaleae sp., dan Siginella signifera. Kepadatan Ascidiacea berdasarkan stasiun tertinggi pada stasiun I dan berdasarkan jenis tertinggi dari jenis Didemnum molle sebesar 54,67 individu/m² dengan nilai kepadatan rata-rata Ascidiacea yaitu 6,73 individu/m². Sementra itu substrat yang paling banyak ditempati Ascidiacea yaitu jenis death coral with alga (DCA). Kondisi terumbu karang pada lokasi penelitian dengan persentase karang hidup rata-rata 34,36 % pada slope dan 46,71 % pada flat berdasarkan satasiun tertinggi pada stasiun 3 dengan persentase 38,6 % pada slope dan 55,32 %  pada flat.Kata Kunci : Tunikata, Chordata, Terumbu Karang, Wakatobi.
STUDI JENIS IKAN YANG BERASOSIASI DENGAN PADANG LAMUN DI PERAIRAN DESA LIYA MAWI KECAMATAN WANGI-WANGI SELATAN KABUPATEN WAKATOBI
Authors: Jalil Muhammad , Nurgayah Wa , Ira .
Published: October 2021

Ikan merupakan salah satu organisme akuatik yang rentan terhadap perubahan lingkungan terutama yang diakibatkan oleh aktifitas manusia baik secara langsung maupun tidak langsung. Setiap jenis ikan dapat hidup dan berkembang biak, mampu menyesuaikan diri dengan kondisi lingkungannya dimana ikan itu hidup. Penelitian bertujuan untuk mengetahui jenis ikan yang berasosiasi di padang  lamun dan mengetahui jenis persen penutupan lamun di Perairan Desa Liya Mawi Kecamatan Wangi-Wangi Selatan Kabupaten Wakatobi. Penelitian ini dilaksanakan pada bulan April 2019 - Mei 2020. Pengambilan data ikan menggunakan jaring insang dan bubu. Pengambilan data persen penutupan lamun menggunakan metode transek kuadrat dengan panjang 100 m dan transek kuadrat 1 m × 1 m. Hasil penelitian menunjukkan, ikan yang ditemukan pada lokasi penelitian sebanyak 821 individu yang berasal dari 1 kelas 10 family dan 18 spesies. Untuk jenis lamun yang ditemukan 2 yaitu C. serrulata dan T. hemprichii dengan kategori persen penutupan lamun sangat padat pada stasiun I (76,83%), persen penutupan lamun sedang pada stasiun II (42,67%), persen penutupan lamun jarang pada stasiun III (23,83%).Kata Kunci: Jenis Lamun, Komposisi Jenis Ikan, Persen Penutupan Lamun
Financial Performance Analysis of NBFC-MFIs in India using TOPSIS and IV-TOPSIS
Authors: Roy Priyanka , Patro Binoti
Published: October 2021

The policymakers around the globe have been emphasizing on financial inclusion in line with sustainable development goals 2030 of the United Nations. Developing countries are still behind in ensuring greater financial inclusion especially for women. While banks are the apex financial institutions in any country, microfinance institutions proved to be promising in advancing financial inclusion because of its better reach to women in remote areas. Thus in a country like India, the outreach and sustainability of microfinance institutions is of utmost importance. This paper aims to rank the performance of microfinance institutions listed by Reserve Bank of India on the basis of their outreach, sustainability, quality and efficiency. The ranking is done separately for five years (2014-15 to 2018-19) using Technique for Order of Preference (TOPSIS) method while overall ranking and benchmarking for five years has been done using interval valued TOPSIS (IV-TOPSIS) method. The robustness of the study has been checked through sensitivity analysis. The overall results portray Satin Creditcare Network Limited as the best performing NBFC-MFI while BWDA Finance Limited as the worst performer for the combined period of 5 years
Aeroallergens and Climate Change in Tulsa, Oklahoma: Long-Term Trends in the South Central United States
Authors: Levetin Estelle
Published: October 2021

Climate change is having a significant effect on many allergenic plants resulting in increased pollen production and shifts in plant phenology. Although these effects have been well-studied in some areas of the world, few studies have focused on long-term changes in allergenic pollen in the South Central United States. This study examined airborne pollen, temperature, and precipitation in Tulsa, Oklahoma over 25 to 34 years. Pollen was monitored with a Hirst-type spore trap on the roof of a building at the University of Tulsa and meteorology data were obtained from the National Weather Service. Changes in total pollen intensity were examined along with detailed analyses of the eight most abundant pollen types in the Tulsa atmosphere. In addition to pollen intensity, changes in pollen season start date, end date, peak date and season duration were also analyzed. Results show a trend to increasing temperatures with a significant increase in annual maximum temperature. There was a non-significant trend toward increasing total pollen and a significant increase in tree pollen over time. Several individual taxa showed significant increases in pollen intensity over the study period including spring Cupressaceae and Quercus pollen, while Ambrosia pollen showed a significant decrease. Data from the current study also indicated that the pollen season started earlier for spring pollinating trees and Poaceae. Significant correlations with preseason temperature may explain the earlier pollen season start dates along with a trend toward increasing March temperatures. More research is needed to understand the global impact of climate change on allergenic species, especially from other regions that have not been studied.
Bone-Forming Peptide-4 Induces Osteogenic Differentiation and VEGF Expression on Multipotent Bone Marrow Stromal Cells
Authors: Kim Mi Eun , Seon Jong Keun , Kang Ju Yeon , Yoon Taek Rim , Lee Jun Sik , Kim Hyung Keun
Published: October 2021

Bone morphogenetic proteins (BMPs) have been widely used as treatment for bone repair. However, clinical trials on fracture repair have challenged the effectiveness of BMPs and suggested that delivery of multipotent bone marrow stromal cells (BMSCs) might be beneficial. During bone remodeling and bone fracture repair, multipotent BMSCs differentiate into osteoblasts or chondrocytes to stimulate bone formation and regeneration. Stem cell-based therapies provide a promising approach for bone formation. Extensive research has attempted to develop adjuvants as specific stimulators of bone formation for therapeutic use in patients with bone resorption. We previously reported for the first time bone-forming peptides (BFPs) that induce osteogenesis and bone formation. BFPs are also a promising osteogenic factor for prompting bone regeneration and formation. Thus, the aim of the present study was to investigate the underlying mechanism of a new BFP-4 (FFKATEVHFRSIRST) in osteogenic differentiation and bone formation. This study reports that BFP-4 induces stronger osteogenic differentiation of BMSCs than BMP-7. BFP-4 also induces ALP activity, calcium concentration, and osteogenic factors (Runx2 and osteocalcin) in a dose dependent manner in BMSCs. Therefore, these results indicate that BFP-4 can induce osteogenic differentiation and bone formation. Thus, treatment of multipotent BMSCs with BFP-4 enhanced osteoblastic differentiation and displayed greater bone-forming ability than BMP-7 treatment. These results suggest that BFP-4-stimulated cell therapy may be an efficient and cost-effective complement to BMP-7-based clinical therapy for bone regeneration and formation.
PerfuPul—A Versatile Perfusable Platform to Assess Permeability and Barrier Function of Air Exposed Pulmonary Epithelia
Authors: Carius Patrick , Dubois Aurélie , Ajdarirad Morvarid , Artzy-Schnirman Arbel , Sznitman Josué , Schneider-Daum Nicole , Lehr Claus-Michael
Published: October 2021

Complex in vitro models, especially those based on human cells and tissues, may successfully reduce or even replace animal models within pre-clinical development of orally inhaled drug products. Microfluidic lung-on-chips are regarded as especially promising models since they allow the culture of lung specific cell types under physiological stimuli including perfusion and air-liquid interface (ALI) conditions within a precisely controlled in vitro environment. Currently, though, such models are not available to a broad user community given their need for sophisticated microfabrication techniques. They further require systematic comparison to well-based filter supports, in analogy to traditional Transwells®. We here present a versatile perfusable platform that combines the advantages of well-based filter supports with the benefits of perfusion, to assess barrier permeability of and aerosol deposition on ALI cultured pulmonary epithelial cells. The platform as well as the required technical accessories can be reproduced via a detailed step-by-step protocol and implemented in typical bio-/pharmaceutical laboratories without specific expertise in microfabrication methods nor the need to buy costly specialized equipment. Calu-3 cells cultured under liquid covered conditions (LCC) inside the platform showed similar development of transepithelial electrical resistance (TEER) over a period of 14 days as cells cultured on a traditional Transwell®. By using a customized deposition chamber, fluorescein sodium was nebulized via a clinically relevant Aerogen® Solo nebulizer onto Calu-3 cells cultured under ALI conditions within the platform. This not only allowed to analyze the transport of fluorescein sodium after ALI deposition under perfusion, but also to compare it to transport under traditional static conditions.
A Paper-Based IL-6 Test Strip Coupled With a Spectrum-Based Optical Reader for Differentiating Influenza Severity in Children
Authors: Lin Sheng-Wen , Shen Ching-Fen , Liu Ching-Chuan , Cheng Chao-Min
Published: October 2021

Influenza virus infection is a major worldwide public health problem. Influenza virus infections are associated with a high hospitalization rate in children between the ages of 5 and 14. The predominant reason for poor influenza prognosis is the lack of any effective means for early diagnosis. Early diagnosis of severe illness is critical to improving patient outcome, and could be especially useful in areas with limited medical resources. Accurate, inexpensive, and easy-to-use diagnostic tools could improve early diagnosis and patient outcome, and reduce overall healthcare costs. We developed an interleukin-6 paper-based test strip that used colloidal gold-conjugated antibodies to detect human interleukin-6 protein. These complexes were captured on a paper-based test strip patterned with perpendicular T lines that were pre-coated with anti-human interleukin-6 antibodies. Applied serum samples interacted with these antibodies and presented as colored bands that could be read using a spectrum-based optical reader. The full-spectrum of the reflected light interleukin-6 protein signal could be obtained from the spectral optics module, and the standard could be used to quantitatively analyze interleukin 6 level in serum. We retrospectively evaluated 10 children (23 serum samples) with severe influenza virus infections, 26 children (26 serum samples) with mild influenza virus infections, and 10 healthy children (10 serum samples). Our system, the combined use of a paper-based test strip and a spectrum-based optical reader, provided both qualitative and quantitative information. When used with the optical reader, the detection limit was improved from a qualitative, naked-eye level of 400 pg/ml to a quantitative, optical reader level of 76.85 pg/ml. After monitoring serum interleukin-6 level via our system, we found a high correlation between our system results and those obtainable using a conventional sandwich enzyme-linked immunosorbent assay method (Rho = 0.706, p < 0.001). The sensitivity and specificity for differentiating between severe and mild influenza using our combined method (test strip coupled with optical reader) were 78.3 and 50.0%, respectively. When interleukin-6 was combined with serum C-reaction protein, the sensitivity and specificity were 85.7 and 95.5%, and the receiver operating characteristic area-under-the-curve was quite high (AUC = 0.911, p < 0.001). The potential advantages of our system, i.e., a paper-based test strip coupled with a spectrum-based optical reader, are as follows: 1) simple user operation; 2) rapid turnaround times–within 20 min; 3) high detection performance; and, 4) low-cost fabrication.
Prospective Life Cycle Assessment at Early Stage of Product Development: Application to Nickel Slag Valorization Into Cement for the Construction Sector
Authors: Quéheille Eva , Dauvergne Michel , Ventura Anne
Published: October 2021

Pyrometallurgical nickel industry in New Caledonia produces several tons of slag per year, which is stocked on site. There is no valorization today, except for a small transformation into sand. Pyrometallurgy highly consumes fossil-fuel energy and electricity for ore pre-treatment and nickel extraction inside electrical furnaces, which produces significant CO2 emissions. A new valorization approach is suggested to use these two local productions (slag and CO2) to mineralize slag and produce silico-magnesian cement for the construction sector. In order to ensure suitable environmental performances, many questions arise about the target valorized product: where and how to capture CO2 and produce cement, what constraints should be targeted for the mineralization process, can products be exported and where? Moreover, New Caledonia aims to develop renewable energies for electricity grid, which would mitigate local industries impacts in the future. A prospective Life Cycle Assessment (LCA) is used to define constraints on future product development. Two hundred scenarios are defined and compared as well as electricity grid evolution, using Brightway software. Thirteen scenarios can compete with traditional Portland cement for 12 of the 16 impacts of the ILCD midpoint method. The evolution of electricity grid slightly affects the performance of the scenarios by a mean of less than+/−25%, bringing a small difference on the number of acceptable scenarios. The main constraint requires improving the mineralization process by considerably reducing electricity consumption of the attrition-leaching operation. To be in line with scenarios concerning carbon neutrality of the cement industry by 2050, a sensitivity analysis provides the maximum energy consumption target for the mineralization process that is 0.9100 kWh/kg of carbonated slag, representing a 70% reduction of the current energy measured at lab scale. Valorization of nickel slag and CO2 should turn to carbon capture and utilization technology, which allows for the production of supplementary cementitious materials, another product for the construction sector. It will be the topic of a next prospective study.
The Role of Androgen Receptor in Cross Talk Between Stromal Cells and Prostate Cancer Epithelial Cells
Authors: Tang Qianyao , Cheng Bo , Dai Rongyang , Wang Ronghao
Published: October 2021

Prostate cancer (PCa) lists as the second most lethal cancer for men in western countries, and androgen receptor (AR) plays a central role in its initiation and progression, which prompts the development of androgen deprivation therapy (ADT) as the standard treatment. Prostate tumor microenvironment, consisting of stromal cells and extracellular matrix (ECM), has dynamic interactions with PCa epithelial cells and affects their growth and invasiveness. Studies have shown that both genomic and non-genomic AR signaling pathways are involved in the biological regulation of PCa epithelial cells. In addition, AR signaling in prostate stroma is also involved in PCa carcinogenesis and progression. Loss of AR in PCa stroma is clinically observed as PCa progresses to advanced stage. Especially, downregulation of AR in stromal fibroblasts dysregulates the expression levels of ECM proteins, thus creating a suitable environment for PCa cells to metastasize. Importantly, ADT treatment enhances this reciprocal interaction and predisposes stromal cells to promote cell invasion of PCa cells. During this process, AR in PCa epithelium actively responds to various stimuli derived from the surrounding stromal cells and undergoes enhanced degradation while elevating the expression of certain genes such as MMP9 responsible for cell invasion. AR reduction in epithelial cells also accelerates these cells to differentiate into cancer stem-like cells and neuroendocrine cells, which are AR-negative PCa cells and inherently resistant to ADT treatments. Overall, understanding of the cross talk between tumor microenvironment and PCa at the molecular level may assist the development of novel therapeutic strategies against this disease. This review will provide a snapshot of AR’s action when the interaction of stromal cells and PCa cells occurs.
HMG-Coenzyme A Reductase as a Drug Target for the Prevention of Ankylosing Spondylitis
Authors: Zhong Zhenyu , Feng Xiaojie , Su Guannan , Du Liping , Liao Weiting , Liu Shengyun , Li Fuzhen , Zuo Xianbo , Yang Peizeng
Published: October 2021

Statins are an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR). Growing evidence indicates that statins may have an anti-inflammatory effect. Whether genetically proxied HMGCR inhibition can reduce the risk of ankylosing spondylitis is unknown. We constructed an HMGCR genetic score comprising nearly randomly inherited variants significantly associated with LDL cholesterol levels within ± 100 kb from HMGCR to proxy for inhibition of HMGCR. We also constructed PCSK9 and NPC1L1 scores as well as the LDL polygenetic score to proxy for the inhibition of these drug targets as well as serum LDL cholesterol levels, respectively. We then compared the associations of these genetic scores with the risk of ankylosing spondylitis. Of 33,998 participants in the primary cohort, 12,596 individuals had been diagnosed with ankylosing spondylitis. Genetically proxied inhibition of HMGCR scaled to per mmol/L decrease in LDL cholesterol levels by the HMGCR score was associated with a lower risk of ankylosing spondylitis (OR, 0.57; 95% CI, 0.38–0.85; P value = 5.7 × 10–3). No significant association with ankylosing spondylitis was observed for the PCSK9 score (OR, 0.89; 95% CI, 0.68–1.16) and the NPC1L1 score (OR, 1.50; 95% CI, 0.39–5.77). For the LDL score, genetically determined per mmol/L decrease in LDL cholesterol levels led to a reduced risk of ankylosing spondylitis (OR, 0.64; 95% CI, 0.43–0.94), with significant heterogeneity and pleiotropy in the estimate. Exploratory analyses showed that genetically proxied inhibition of HMGCR appeared to have a similar effect to long-term statin therapy in modifying the risk of coronary artery disease and type 2 diabetes, suggesting that the HMGCR score might be a reliable model to assess the effect of statin. Genetically proxied inhibition of HMGCR was associated with a decreased risk of ankylosing spondylitis. This mechanism-based estimate was in line with existing observations suggesting the clinical benefits of statin therapy for ankylosing spondylitis.
Exploration of Pattern Recognition Receptor Agonists as Candidate Adjuvants
Authors: Ong Guang Han , Lian Benedict Shi Xiang , Kawasaki Takumi , Kawai Taro
Published: October 2021

Adjuvants are used to maximize the potency of vaccines by enhancing immune reactions. Components of adjuvants include pathogen-associated molecular patterns (PAMPs) and damage-associate molecular patterns (DAMPs) that are agonists for innate immune receptors. Innate immune responses are usually activated when pathogen recognition receptors (PRRs) recognize PAMPs derived from invading pathogens or DAMPs released by host cells upon tissue damage. Activation of innate immunity by PRR agonists in adjuvants activates acquired immune responses, which is crucial to enhance immune reactions against the targeted pathogen. For example, agonists for Toll-like receptors have yielded promising results as adjuvants, which target PRR as adjuvant candidates. However, a comprehensive understanding of the type of immunological reaction against agonists for PRRs is essential to ensure the safety and reliability of vaccine adjuvants. This review provides an overview of the current progress in development of PRR agonists as vaccine adjuvants, the molecular mechanisms that underlie activation of immune responses, and the enhancement of vaccine efficacy by these potential adjuvant candidates.