bluuebunny/crossref_metadata_2025 huggingface dataset:
Tactics of treatment of complicated forms of central serous chorioretinopathy according to preoperative OCT predictors
Authors:   The S. Fyodorov Eye Microsurgery Federal State Institution, Kaluga Branch, Kaluga, Kirilenko I.Y. , Erokhina E.V. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, Kaluga Branch, Kaluga, Sidorova Y.A. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, Kaluga Branch, Kaluga
Published: June 2022

The purpose is to determine preoperative OCT predictors and, based on the data obtained, to develop a treatment strategy for patients with a chronic form of central serous chorioretinopathy (CSCRP) complicated by choroidal neovascularization (CNV) type 1. Material and methods. A retrospective analysis of 53 patients with a chronic form of CSCRP complicated by CNV type 1 was carried out, 30 men (56.6 %) and 23 women (43.4 %). The first (control) group included 27 patients for whom inhibitors angiogenesis intravitreal injection (IAIVI) monotherapy was effective, and a positive clinical response after the first IAIVI was observed. The second (main) group included 26 patients in whom IAIVI as monotherapy did not lead to the sensorineural retina reattachment, and combined treatment was performed: one day before IAIVI, selective micro-pulse laser exposure (SMPLE) was performed. All patients underwent optical coherence tomography (OCT) and OCT in angio mode (OCTA) on the device “RTVue XR Avanti Angiovue” (Optovue, USA). Results. In patients with a chronic form of CSCRP complicated by CNV type 1, the main OCT predictors indicating the predominance of the role of one of the two co-existing pathologies are the initial thickness of the choroid and the area of CNV type 1. The initial pachychoroidal vascular change, which has a value of more than 490 microns, and the area of CNV not exceeding 0.300 mm2, indicate the predominance of CSCRP as the main mechanism of transudative detachment of the sensorineural retina and require combined treatment (SMPLE + IAIVI). Conclusion. The identified predictors contribute to the timely selection of a pathogenetically sound treatment method, which accelerates the resorption of subretinal fluid and promotes faster sensorineural retina reattachment, thereby improving the functional results of the treatment. Keywords: central serous chorioretinopathy, choroidal neovascularization, optical coherence tomography, selective micro-pulse laser exposure, angiogenesis inhibitors intravitreal injection.
Optical biometry results in association with orthokeratological correction
Authors:   The S. Fyodorov Eye Microsurgery Federal State Institution, Tambov branch, Tambov, Russian Federation, Kutimova E.Y. , Matrosova Y.V. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, Tambov branch, Tambov, Russian Federation,   FSBEI HPE “Tambov State University named after G.R. Derzhavin”, Medical Institute, Tambov, Russian Federation, Fabrikantov O.L. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, Tambov branch, Tambov, Russian Federation,   FSBEI HPE “Tambov State University named after G.R. Derzhavin”, Medical Institute, Tambov, Russian Federation
Published: June 2022

Purpose. To research the dynamics of optical biometry data in association with orthokeratological (OK) correction. Material and methods. Case histories of 400 patients (800 eyes) with mild, average and high myopia in association with OK-correction were studied. Besides the routine ophthalmic examination, all patients underwent optical biometry on device IOL-Master (Carl Zeiss) before OK-lens fitting and every year of lens wearing (maximum 5 years). The outcomes of patients with visual acuity 0.9–1.0 and 0.7–0.8 in association with OK-correction were compared separately. Results. There was noted the increase in axial length of the eye (APA) in the majority of patients according to optical biometry data. The significant differences of the annual gradient of myopic progression were revealed: it was significantly lower in patients with visual acuity 0.9–1.0 in association with OK-correction in comparison with patients with hypocorrection and visual acuity 0.7–0.8. Conclusion. In those cases when OK-lenses is fitted to slow down myopic progression, it is necessary to achieve the full myopic correction and maximum visual acuity (0.9–1.0). Keywords: orthokeratology, myopia, annual gradient of progression, peripheral defocus, optical biometry.
The role of smoking, overweight, СFH (rs1061170) and ARMS2 (rs10490924) genes in patients with dry form of age-related macular degeneration
Authors:   North-Western State Medical University named after I.I. Mechnikov, Milko T.S. , Khokkanen V.M. ,   North-Western State Medical University named after I.I. Mechnikov
Published: June 2022

Purpose. To evaluate the role of smoking, excess body weight, CFH and ARMS 2 gene polymorphisms in patients with the dry form of age-related macular degeneration (AMD). Material and мethods. There were selected seventy-five people (150 eyes) with overweight or obesity. They were checked for having a smoking habit. Their body mass index, and CFH and ARMS2 gene polymorphisms were determined. Patients underwent standard eye exam and retinal electrophysiological examination (EPI). Results. All patients were divided into two groups: overweight smokers and nonsmokers. The group of nonsmokers was significantly younger. Molecular genetic testing revealed more patients with low-risk AMD genotypes in the nonsmoking group and more patients with moderate-risk genotypes in the smoking group. Examination of the fundus showed that smokers in most cases have retinal changes typical for “AREDS category 2,3,4”; nonsmokers in most cases have “AREDS category 1” including normal retina. Thus, corrected visual acuity, static computer perimetry and EPI values were lower in the group of overweight smokers. Conclusion. The study results in the group of overweight patients who smoked were significantly lower because this group included patients with more severe stages of AMD with high-risk genotypes of the genes studied. Thus, smoking, overweight, SFH (rs1061170) and ARMS2 (rs10490924) polymorphisms may also be related to the risk of development and possibly progression of АMD. Keywords: age-related macular degeneration, smoking, overweight, СFH, ARMS2.
Relationship between the number of intravitreal injections received by patients and the frequency of detection of silicone oil droplets in the vitreous
Authors:   Ural State Medical University, Yekaterinburg, Russia, Akimenko I.A. , Bobykin E.V. ,   Ural State Medical University, Yekaterinburg, Russia, Morozova O.V. ,   Ural State Medical University, Yekaterinburg, Russia, Krokhalev V.Y. ,   Ural State Medical University, Yekaterinburg, Russia
Published: June 2022

Intravitreal injections (IVI) are widely used in current clinical ophthalmology as a method of drug delivery. One of the adverse events of the procedure is translocation of silicone oil droplets (SOD) into the vitreous body, which is a component of single-use syringes. Purpose. To evaluate the frequency of detection of SOD in the vitreous of patients who received multiple IVI of drug solutions; to evaluate the relationship of the frequency of SOD detection on the number of IVI performed. Material and methods. A single-center retrospective cohort study was performed. The study group consisted of 86 eyes of 85 patients who received an average of 13.2 IVI. SOD in the vitreous was detected by biomicroscopy in 57 eyes (66.28 %), by ultrasonography in 76 (88.37 %) cases. The results between methods matched in 73.26 % of observations. The hypothesis put forward in the course of the study about an increase in the probability of SOD getting into the vitreous body with an increase in the number of IVI was confirmed statistically. Conclusion. Translocation of SOD into the vitreous in IVI is a problem that is relevant for current ophthalmology and requires further study and solution. Among the ways to solve the problem are the registration of drugs for IVI in prefilled syringes, as well as the development of syringe models that take into account the specifics of use in ophthalmology. Keywords: intravitreal injection, silicone oil droplets, syringe, biomicroscopy, ultrasonography.
Features of local hypotensive therapy in patients with primary open-angle glaucoma
Authors:   FGKU “KDC GSH of the Armed Forces of the Russian Federation”, Moscow, Nefedov N.A. , Alexandrov A.S. ,   FGKU “KDC GSH of the Armed Forces of the Russian Federation”, Moscow, Alexandrova L.A. ,   FGKU “KDC GSH of the Armed Forces of the Russian Federation”, Moscow, Korneva K.S. ,   FGKU “KDC GSH of the Armed Forces of the Russian Federation”, Moscow, Kushim Z.P. ,   FGKU “KDC GSH of the Armed Forces of the Russian Federation”, Moscow, Lyasota E.V. ,   FGKU “KDC GSH of the Armed Forces of the Russian Federation”, Moscow, Orlovskaya L.E. ,   FGKU “KDC GSH of the Armed Forces of the Russian Federation”, Moscow
Published: June 2022

Purpose. To evaluate the dynamics of local hypotensive therapy in patients with primary open-angle glaucoma (POAG) under dynamic observation. Material and methods. A retrospective study of the administration of local antihypertensive medications to patients who are registered and dynamically monitored by an ophthalmologist for POAG (n = 254) was conducted. Among the examined persons there were 183 men (72 %) and 71 women (28 %). The age of the patients was 76,8 ± 9,5 years. The duration of the disease from the moment of diagnosis was 9,3 ± 6,3 years, the duration of observation in the polyclinic was 3,9 ± 2,9 years. Results. To assess the dynamics of local antihypertensive therapy, a retrospective study of the administration of local antihypertensive medications to patients with primary open – angle glaucoma (POAG) (n = 254, 183 people – men (72 %) and 71 people-women (28 %)) was conducted. Age: 76.8 ± 9.5 years. Duration of the disease: 9.3 ± 6.3 years, duration of follow-up: 3.9 ± 2.9 years. Suspicion of glaucoma was determined in 6 people (2 %), POAG I st. – 118 people (46 %), POAG II st. – 43 people (17 %), POAG III st. – 70 people (28 %), POAG IV st. – 17 people (7 %). Concomitant organ pathology was detected in 250 people (99.6 %). Conclusion. The appointment of local hypotensive therapy was required by 98 % of patients with glaucoma. In the dynamic follow-up of patients with glaucoma, there was a significant decrease by 18.4 % in the proportion of people who were prescribed monotherapy, and a significant increase by 19.2 % in the proportion of people who received combination therapy. Strengthening of the instillation regime during the observation period was required in 42.3 % of cases. As a result of the treatment and follow-up, the target IOP levels were achieved in 76.6 % of cases: in 97.3 % of cases with POAG I st., in 59.3 % with POAG II st., in 55.4 % with POAG III st., and in 47.1 % with POAG IV st. Keywords: primary open-angle glaucoma, drug treatment, eye drops.
Experience of radiosurgical occlusion of lacrimal passage with a lack of tear production
Authors:   The S. Fyodorov Eye Microsurgery Federal State Institution, the Cheboksary Branch, Vasilyeva A.Y. , Shkolnik S.F. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Cheboksary Branch
Published: June 2022

The purpose of the study was the effective assessment and safety of the lacrimal ducts obturation by using radio wave energy in patient with “dry eye” syndrome with sagnificant damage of the ocular surface. Materials and methods. A retrospective analysis of data as patients radiosurgical blocking of tear flow was performed was carried out. Occlusion of the lacrimal ducts was carried out according to the own method using “Surgitron™” devices. The radio wave low-temperature event leads to persistent closure of the lumen of the lacrimal ducts and blockage of the passage of the lacrimal fluid. Results and discussion. The study included 49 patients (79 eyes), of different age groups, with severe manifestations of the “dry eye” syndrome. All patients after the procedure observd an improvement in their condition, an objective examination showed an increase in tear production, tear test values and visual acuity compared to the initial state. Over the entire period of observation, spontaneous recanalization of the lacrimal ducts occurred only in 2 patients (4 %) (3 eyes), which is significantly less in detection with other surgical methods of occlusion of the lacrimal ducts. Conclusion. Radiosurgical lacrimal blockage is an alternative method of surgical treatment of patients with “dry eye” syndrome wich allows to achieve a good functional result. It is supposed to be clinically atraumatic, bloodless and aesthetic. A small percentage of spontaneous recanalization of open tracts of high efficiency and preservation of the result after radiosurgical blocking of lacrimal drainage. Keywords: “dry eye” syndrome, punctal occlusion surgery, radiosurgical occlusion of lacrimal passage, lacrimal punctum plug.
Method of endoscopic decompression of the orbit and optic nerve in cavernous sinus thrombosis
Authors:   Tashkent Medical Academy, Ministry of Health of the Republic of Uzbekistan, Oripov O.I. , Umarov R.Z. ,   Center for the Development of Professional Qualifications of Medical Workers, Ministry of Health of the Republic of Uzbekistan
Published: June 2022

Purpose. To study the effectiveness of the method of endoscopic decompression of the orbit and the optic nerve through its medial wall in case of cavernous sinus thrombosis. Material and мethods. The study included 20 patients (11 men (55 %) and 9 women (45 %)) with COVID-19 associated cavernous sinus thrombosis, which was complicated by the development of a pyoinflammatory process in the orbit. The study group included 12 patients who underwent surgical treatment according to proposed method. As a comparative group, we took the results of a retrospective analysis of 8 cases in which patients underwent traditional transcutaneous orbitotomy. Results. The study showed that endoscopic access to perform orbitotomy through its medial wall is associated with a smaller number of subsequent developments of endophthalmitis and panophthalmitis, which may require enucleation or exentration. Endoscopic access allowed saving the eyeball in most patients in comparison with traditional transcutaneous orbitotomy. Conclusion. Endoscopic decompression of the orbit through its medial wall with the development of a purulent-inflammatory process in the orbit with thrombosis of the cavernous sinus reduces the risk of developing endo- and panophthalmitis, which contributes to the preservation of the eyeball as an organ. Keywords: cavernous sinus thrombosis, COVID-19 associated cavernous sinus thrombosis, phlegmon of the orbit, endoscopic decompression of the orbit and optic nerve.
Manajemen Penyelenggaraan Analisis Jabatan Aparatur Sipil Negara Pada Sekretariat Daerah Provinsi Riau
Authors: Sudiarto Riyadi , Febrian Ranggi
Published: June 2022

Fundamentally, the implementation of Bureaucratic Reform within government agencies, both central and regional, mandates an objective change of the proportional bureaucratic institutional structure and the improvement of thequality of the human resources of the apparatus. The President, through The Ministry of State Apparatus Utilization And Bureaucratic Reform, encourages local governments to create government organizations that have the right function,process and size. One way to achieve this is through job analysis. Management of the implementation of a good job analysis will produce a good quality of job requirements planning. Management of the Implementation of Job Analysis consists of planning, organizing, actuating, controlling (Terry Theory) actions, which are carried out to achieveorganizational goals and use professional employees. From the results of research at the Regional Secretariat of Riau Province that in the planning phase, the preparation of the job analysis is carried out before the organizational structure change activity is determined, so that this jump is less effective and has the potential to repeat the preparation of the jobanalysis again. In the organizing phase, the average placement of employees is not based on educational qualifications and competencies. The name of the position attached to the employee actually brings the employee's exclusive nature and cannot do various work tasks (multi-tasking) for the organization. This has the potential to reduce performance and harm the organization. In terms of actuating, organizational leaders are still weak in moving their subordinates to be more professional. In the controlling phase, the preparation of the job analysis is supervised by 2 institutions, namely the Regional Inspectorate and the Supreme Audit Agency. However, in the preparation process, there were several steps thatwere not carried out, such as distributing the questionnaire form or direct interviews, this was not done because the preparation of the job analysis at the Regional Secretariat was already using the application system. Then the Teamwas only formed without a Regional Head Decree. It can be said that it does not have a strong legal umbrella inconducting the preparation of job analysis.
Türkiye’de Hanehalkı Gelir Gruplarına Göre Gıda Harcamalarının Analizleri
Authors: YILDIRIM Evren , ÇOBANOĞLU Ferit
Published: June 2022

Çalışmanın temel amacı, hanehalklarının ekonomik ve demografik özelliklerini de dikkate alarak hanehalklarının gıda alt ürün gruplarının genel talep parametreleri ile gelir esnekliklerini hesaplamaktır. Ayrıca %20’lik gelir grupları ayrımı itibariyle hanehalklarının sosyoekonomik özellikleri ile gıda harcamaları tutar ve dağılımlarını göstermektir. Bu çalışmanın ana materyalini, 2015‐2016‐2017 yıllarına ait Türkiye İstatistik Kurumu Başkanlığı’ndan sağlanmış olan Hanehalkı Bütçe Araştırması mikro veri setleri oluşturmaktadır. Çalışmada veriler hanehalklarının yıllık kullanılabilir gelir düzeylerine göre küçükten büyüğe doğru sıralanarak beş eşit %20’lik gelir grubuna ayrılmıştır. Hanehalklarının sosyoekonomik özellikleri ile gıda alt ürün grupları tutar ve payları bu gelir grupları ayrımı itibariyle analiz edilmiştir. Çalışmada genel veri seti kapsamında ise gıda alt ürün grupları Working‐Leser Modeli yöntemi ile analiz edilmiştir. Ayrıca çalışmada sıfır harcamalı gözlemlerden dolayı yanlı ve tutarsız tahminlere neden olmamak için Heckman İki Aşamalı Talep Modeli kullanılmıştır. Çalışmada 2017 yılı “Balık ve Deniz Ürünleri” harcamaları hariç tüm yıllarda tüm harcama grupları birden küçük pozitif işaretli normal harcama olarak bulunmuştur. Tüm yıllarda “Et ve Et Ürünleri” harcamaları” birim esnek harcama, diğer gıda alt ürün grupları zorunlu‐ihtiyaç harcaması olarak bulunmuştur. Ayrıca tüm yıllarda en düşük gelir esneklikleri “Kahve ve Çay”, “Alkolsüz İçecekler”, 2017 yılı hariç “Ekmek ve Diğer Tahıl Ürünleri”; en yüksek gelir esnekliği “Et ve Et Ürünleri” harcamaları için hesaplanmıştır. Bu çalışmanın bulguları konuya ilgi duyan şahıs ve kurumlar için yararlı olacağı düşünülmektedir.
The Effect of Mycorrhiza, Iron and Zinc Applications on Yield and Agronomic Characters in Peanut (Arachis hypogea L.)
Authors: KAYA Ayşe , ÜNAY Aydın
Published: June 2022

The exogenous applications of arbuscular mycorrhizal fungi (AMF), iron and zinc have the potential to increase yield in peanut. The objective of this study was to evaluate the effects of AMF, Fe and Zn combinations on yield and yield components in peanut. Seed coating with AMF and foliar sprays of Fe and Zn were arranged in split-split block design with four replications under farmer’ condition in 2020. The highest values for pod number per plant, pod and kernel yield (kg ha-1) and 100 seed weight were recorded in parcels where AMF, Fe and Zn were applied together. The combination of AMF, Fe and Zn favorable affected maturity date and harvest index. It was highlighted that AMF, Fe and Zn combinations could be used successfully to improve the yield and in peanut cultivation.
Muğla İli Örtü Altı Domates Yetiştiriciliğinde Fitopatolojik Uygulamalar ve Üretici Bilincinin Değerlendirilmesi
Authors: KOR Aslı , DİNLER Havva
Published: June 2022

Bu çalışmada domates üretiminin yoğun olarak yapıldığı Muğla ili Seydikemer, Fethiye ve Ortaca ilçelerinde örtü altı domates yetiştiriciliği yapan üreticilerin yetiştiricilik deneyimleri, karşılaştıkları fitopatolojik sorunlar, bitki koruma uygulamaları konusunda bilgi düzeylerinin ve tarımsal ilaç kullanımındaki eğilimlerinin belirlenmesi amaçlanmıştır. Bu amaçla, 2019 yılında basit tesadüfi örnekleme yöntemine göre örtü altı domates yetiştiriciliği yapan ve rastgele seçilen 100 üreticiyle birebir görüşülerek, 55 soruluk anket çalışması yürütülmüş ve verilen cevaplar değerlendirilmiştir. Elde edilen sonuçlara göre, üreticilerin %85’inin ilkokul mezunu olduğu, daha çok polietilen (%61) örtülü seraları tercih ettikleri, genellikle 1-2 dekar arasında değişen küçük ölçekli aile işletmelerinde uzun yıllar yetiştiricilik yaptıkları belirlenmiştir. Bu seralarda başta domates (%51) olmak üzere hıyar (%19), patlıcan(%17) ve fasulye (%13) yetiştiriciliği yapıldığı belirlenmiştir. Üreticilerin çeşit seçimini kendileri ya da zirai ilaç bayinin önerisine göre yaptığı, üreticilerin tamamının hazır fide kullandığı ve %73’ünün aşısız fide ile üretime başladığı tespit edilmiştir. Anket verilerine göre, üreticilerin, kimyasal mücadelenin gerekli olduğu (%59), kimyasal mücadeleye kendi bilgileri doğrultusunda karar verdikleri, ilaçları seçerken etkili olmasına dikkat ettikleri (%94), ilaçları karıştırarak kullandıkları, daha çok fungal hastalıklara karşı düzenli ilaçlama yaptıkları (%60), ilaçların bekleme süresine dikkat ettikleri (%97) ortaya konulmuştur.
Determinan Perilaku Seks Pranikah Pada Remaja (15-24 Tahun) Di Indonesia (Analisis SDKI 2017)
Authors: Syafitriani Dewi , Trihandini Indang , Irfandi Julhan
Published: June 2022

Perilaku seks pranikah merupakan salah satu masalah remaja yang sedang menuju dewasa. Transisi sosial dan budaya yang mengakibatkan remaja rentan terpengaruh dampak negatif. Tujuan penelitian menganalisis faktor-faktor yang berhubungan dengan perilaku seks pranikah pada remaja (15-24 tahun) di Indonesia tahun 2017. Penelitian ini menggunakan sebagian data Survei Demografi dan Kesehatan Indonesia (SDKI) tahun 2017 dengan desain cross-sectional. Jumlah sampel sebanyak 23,770 remaja.  Analisis  complex samples menggunakan Chi-Square dan analisis multivariate menggunakan regresi logistik berganda model prediksi. Hasil penelitian didapatkan perilaku seks pranikah pada remaja sebanyak 7,7%. Faktor yang berhubungan dengan perilaku seks pranikah pada remaja yaitu umur POR=4,31, pendidikan POR=1,82, status pekerjaan POR=2,73, pengetahuan kesehatan reproduksi POR=1,73, pengetahuan alat kontrasepsi POR=1,18, sikap (POR=32,05, gaya berpacaran POR= 68,58, dan pengaruh teman sebaya POR=18,25. Faktor yang dominan tehadap perilaku seks pranikah remaja adalah gaya berpacaran POR=20 artinya remaja dengan gaya berpacaran berisiko memiliki risiko 20 kali untuk berperilaku seks pranikah. Untuk itu perlu adanya peningkatan edukasi pada remaja mengenai dampak gaya berpacaran yang berisiko serta pergaulan yang salah.
Extending the Description Logic τEL(deg) with Acyclic TBoxes
Authors: Baader Franz , Gil Oliver Fernández
Published: June 2022

In a previous paper, we have introduced an extension of the lightweight Description Logic EL that allows us to define concepts in an approximate way. For this purpose, we have defined a graded membership function deg, which for each individual and concept yields a number in the interval [0; 1] expressing the degree to which the individual belongs to the concept. Threshold concepts C~t for ~ 2 ∈ {<, ≤, >, ≥} then collect all the individuals that belong to C with degree ~ t. We have then investigated the complexity of reasoning in the Description Logic τEL(deg), which is obtained from EL by adding such threshold concepts. In the present paper, we extend these results, which were obtained for reasoning without TBoxes, to the case of reasoning w.r.t. acyclic TBoxes. Surprisingly, this is not as easy as might have been expected. On the one hand, one must be quite careful to define acyclic TBoxes such that they still just introduce abbreviations for complex concepts, and thus can be unfolded. On the other hand, it turns out that, in contrast to the case of EL, adding acyclic TBoxes to τEL(deg) increases the complexity of reasoning by at least on level of the polynomial hierarchy.
Decidability and Complexity of Threshold Description Logics Induced by Concept Similarity Measures
Authors: Baader Franz , Gil Oliver Fernández
Published: June 2022

In a recent research paper, we have proposed an extension of the lightweight Description Logic (DL) EL in which concepts can be defined in an approximate way. To this purpose, the notion of a graded membership function m, which instead of a Boolean membership value 0 or 1 yields a membership degree from the interval [0; 1], was introduced. Threshold concepts can then, for example, require that an individual belongs to a concept C with degree at least 0:8. Reasoning in the threshold DL T EL(m) obtained this way of course depends on the employed graded membership function m. The paper defines a specific such function, called deg, and determines the exact complexity of reasoning in T EL(deg). In addition, it shows how concept similarity measures (CSMs) ~ satisfying certain properties can be used to define graded membership functions m~, but it does not investigate the complexity of reasoning in the induced threshold DLs T EL(m~). In the present paper, we start filling this gap. In particular, we show that computability of ~ implies decidability of T EL(m~), and we introduce a class of CSMs for which reasoning in the induced threshold DLs has the same complexity as in T EL(deg).
Temporal Query Answering in DL-Lite over Inconsistent Data
Authors: Bourgaux Camille , Turhan Anni-Yasmin
Published: June 2022

In ontology-based systems that process data stemming from different sources and that is received over time, as in context-aware systems, reasoning needs to cope with the temporal dimension and should be resilient against inconsistencies in the data. Motivated by such settings, this paper addresses the problem of handling inconsistent data in a temporal version of ontology-based query answering. We consider a recently proposed temporal query language that combines conjunctive queries with operators of propositional linear temporal logic and extend to this setting three inconsistency-tolerant semantics that have been introduced for querying inconsistent description logic knowledge bases. We investigate their complexity for DL-LiteR temporal knowledge bases, and furthermore complete the picture for the consistent case.
Contextualized Programs for Ontology-Mediated Probabilistic System Analysis
Authors: Dubslaff Clemens , Koopmann Patrick , Turhan Anni-Yasmin
Published: June 2022

Modeling context-dependent systems for their analysis is challenging as verification tools usually rely on an input language close to imperative programming languages which need not support description of contexts well. We introduce the concept of contextualized programs where operational behaviors and context knowledge are modeled separately using domain-specific formalisms. For behaviors specified in stochastic guarded-command language and contextual knowledge given by OWL description logic ontologies, we develop a technique to efficiently incorporate contextual information into behavioral descriptions by reasoning about the ontology. We show how our presented concepts support and facilitate the quantitative analysis of context-dependent systems using probabilistic model checking. For this, we evaluate our implementation on a case study issuing a multi-server system.
Maybe Eventually? Towards Combining Temporal and Probabilistic Description Logics and Queries (Extended Version)
Authors: Koopmann Patrick
Published: June 2022

We present some initial results on ontology-based query answering with description logic ontologies that may employ temporal and probabilistic operators on concepts and axioms. Speci_cally, we consider description logics extended with operators from linear temporal logic (LTL), as well as subjective probability operators, and an extended query language in which conjunctive queries can be combined using these operators. We first show some complexity results for the setting in which either only temporal operators or only probabilistic operators may be used, both in the ontology and in the query, and then show a 2ExpSpace lower bound for the setting in which both types of operators can be used together.
Finite Herbrand Models for Restricted First-Order Clauses
Authors: Borgwardt Stefan , Morawska Barbara
Published: June 2022

We call a Herbrand model of a set of first-order clauses finite, if each of the predicates in the clauses is interpreted by a finite set of ground terms. We consider first-order clauses with the signature restricted to unary predicate and function symbols and one variable. Deciding the existence of a finite Herbrand model for a set of such clauses is known to be ExpTime-hard even when clauses are restricted to an anti-Horn form. Here we present an ExpTime algorithm to decide if a finite Herbrand model exists in the more general case of arbitrary clauses. Moreover, we describe a way to generate finite Herbrand models, if they exist. Since there can be infinitely many minimal finite Herbrand models, we propose a new notion of acyclic Herbrand models. If there is a finite Herbrand model for a set of restricted clauses, then there are finitely many (at most triple-exponentially many) acyclic Herbrand models. We show how to generate all of them.
Role-Value Maps and General Concept Inclusions in the Description Logic FL₀
Authors: Baader Franz , Théron Clément
Published: June 2022

We investigate the impact that general concept inclusions and role-value maps have on the complexity and decidability of reasoning in the Description Logic FL₀. On the one hand, we give a more direct proof for ExpTimehardness of subsumption w.r.t. general concept inclusions in FL₀. On the other hand, we determine restrictions on role-value maps that ensure decidability of subsumption, but we also show undecidability for the cases where these restrictions are not satisfied.
Deciding the Word Problem for Ground Identities with Commutative and Extensional Symbols
Authors: Baader Franz , Kapur Deepak
Published: June 2022

The word problem for a finite set of ground identities is known to be decidable in polynomial time using congruence closure, and this is also the case if some of the function symbols are assumed to be commutative. We show that decidability in P is preserved if we add the assumption that certain function symbols f are extensional in the sense that f(s1,…,sn) ≈ f(t1,…,tn) implies s1 ≈ t1,…,sn ≈ tn. In addition, we investigate a variant of extensionality that is more appropriate for commutative function symbols, but which raises the complexity of the word problem to coNP.
Computing Safe Anonymisations of Quantified ABoxes w.r.t. EL Policies (Extended Version)
Authors: Baader Franz , Kriegel Francesco , Nuradiansyah Adrian , Peñaloza Rafael
Published: June 2022

In recent work, we have shown how to compute compliant anonymizations of quantified ABoxes w.r.t. EL policies. In this setting, quantified ABoxes can be used to publish information about individuals, some of which are anonymized. The policy is given by concepts of the Description Logic (DL) EL, and compliance means that one cannot derive from the ABox that some non-anonymized individual is an instance of a policy concept. If one assumes that a possible attacker could have additional knowledge about some of the involved non-anonymized individuals, then compliance with a policy is not sufficient. One wants to ensure that the quantified ABox is safe in the sense that none of the secret instance information is revealed, even if the attacker has additional compliant knowledge. In the present paper, we show that safety can be decided in polynomial time, and that the unique optimal safe anonymization of a non-safe quantified ABox can be computed in exponential time, provided that the policy consists of a single EL concept.
Privacy-Preserving Ontology Publishing: The Case of Quantified ABoxes w.r.t. a Static Cycle-Restricted EL TBox (Extended Version)
Authors: Baader Franz , Koopmann Patrick , Kriegel Francesco , Nuradiansyah Adrian , Peñaloza Rafael
Published: June 2022

We review our recent work on how to compute optimal repairs, optimal compliant anonymizations, and optimal safe anonymizations of ABoxes containing possibly anonymized individuals. The results can be used both to remove erroneous consequences from a knowledge base and to hide secret information before publication of the knowledge base, while keeping as much as possible of the original information.
Evolution of Aqueous Electron with Varying Temperature
Authors: Lan Jinggang , V. Rybkin Vladimir , Pasquarello Alfredo
Published: June 2022

The nature of the bulk hydrated electron has been a challenge for both experiment and theory due to its short lifetime and high reactivity, and the need for a high-level of electronic structure theory to achieve predictive accuracy. The lack of a classical atomistic structural formula makes it exceedingly difficult to model the solvated electron using conventional empirical force fields, which describe the system in terms of interactions between point particles associated with atomic nuclei. Here we overcome this problem using a machine-learning model, that is sufficiently flexible to describe the effect of the excess electron on the structure of the surrounding water, without including the electron in the model explicitly. The resulting potential is not only able to reproduce the stable cavity structure but also recovers the correct localization dynamics that follow the injection of an electron in neat water. The machine learning model achieves the accuracy of the state-of-the-art correlated wave function method it is trained on. It is sufficiently inexpensive to afford a full quantum statistical and dynamical description and allows us to achieve accurate determination of the structure, diffusion mechanisms, and vibrational spectroscopy of the solvated electron.
20π antiaromatic isophlorins without metallation or core modification
Authors: Sugimura Haruna , Nakajima Kana , Yamashita Ken-ichi , Ogawa Takuji
Published: June 2022

Isophlorins (two-electron-reduced porphyrins) with 20π antiaromaticity have been synthesized by metallation or core modification (replacing the inner NHs with less bulky atoms) thus far. The core-modification number (CMN) is an important factor for the stability of isophlorins against their oxidation to porphyrins. However, isophlorins with small CMN (≤ 2), i.e., without significant core modification, are difficult to synthesize and important for understanding their structure–antiaromaticity relationships. Herein, we report the synthesis of free-base (metal-free) antiaromatic isophlorins with no core modification (CMN=0) for the first time in the literature. β-Tetracyanoporphyrins were successfully reduced by hydrazine to their corresponding isophlorins under aerobic conditions. These porphyrin/isophlorin transformations are reversible. Their structure and antiaromaticity were studied via 1H NMR and UV-vis/near-infrared absorption spectroscopy, X-ray diffraction and theoretical calculations.
Identification of Novel 2,4,5-Trisubstituted Pyrimidines as Potent Dual Inhibitors of Plasmodial PfGSK3/PfPK6 with Activity Against Blood Stage Parasites in vitro
Authors: Galal Kareem , Truong Anna , Kwarcinski Frank , de Silva Chandi , Avalani Krisha , Havener Tammy , Chirgwin Michael , Merten Eric , Ong Han Wee , Willis Caleb , Abdelwaly Ahmad , Helal Mohamed , Derbyshire Emily , Zutshi Reena , Drewry David
Published: June 2022

The plasmodial kinases PfGSK3 and PfPK6 have been identified as essential for the asexual life stage of Plasmodium falciparum, and thus are considered viable novel drug targets to combat rising resistance to traditional antimalarial drugs. We recently identified disubstituted pyrimidine IKK16 as a compound which demonstrated strong activity against blood stage Pf3D7 parasites, while also exhibiting potent activity against PfGSK3 and PfPK6. Here we describe the synthesis of a series of IKK16 analogues and efforts to establish structure activity relationships to develop compounds with enhanced inhibition of PfPK6 and PfGSK3. We made extensive modifications focused on the 2, 4, and 5 positions of the pyrimidine core. The new synthesized compounds were assessed for enzymatic activity on PfGSK3 and PfPK6 using a split luciferase binding assay, and many of them displayed low nanomolar potency against both kinases. The most potent inhibitors were further assessed for activity against blood stage P. falciparum 3D7 parasites as well as liver stage P. berghei parasites. This culminated in the discovery of compounds 23d and 23e which displayed the most promising biological profiles among this set of analogues. Both compounds showed the greatest inhibitory activity against PfGSK3 and PfPK6 (23d PfGSK3 IC50 = 172 nM, PfPK6 IC50 = 11 nM, 23e PfGSK3 IC50 = 97 nM, PfPK6 IC50 = 8 nM) and demonstrated considerable activity against blood stage parasitemia (23d Pf3D7 EC50 = 552 nM, 23e Pf3D7 EC50 = 1400 nM). Also, the ligand efficiency of these compounds was greater than IKK16. Both compounds exhibited significant promiscuity when tested in a panel of human kinase targets. Taken together, our results suggest that dual PfPK6/PfGSK3 inhibitors with antiplasmodial activity can be identified. Our strategy of targeting two plasmodial kinases simultaneously and the structure activity results described herein sets the stage for further optimization efforts with the goal of identifying novel antiplasmodial agents.
Insights into the stability of engineered mini-proteins from their dynamic electronic properties
Authors: Steeves Adam , Kulik Heather
Published: June 2022

An understanding of protein stability requires capturing dynamic rearrangements and coupled properties over long lengthscales. Nevertheless, the extent of coupling in these systems has typically only been studied for classical degrees of freedom. To understand the potential benefit of extending such analysis to the coupling of electronic structure properties, we have carried out extensive semi-empirical quantum mechanical molecular dynamics of two Trp-cage variants. Small differences in the sequence of the two peptides lead to differences in their thermal stability that are revealed through electronic structure coupling analysis. In comparison, we find limited evidence that geometric coupling can distinguish the behavior of the two peptides. We show that Asp1 in the more stable variant shows significantly enhanced coupling to both sequence-adjacent and more sequence-distant residues. Non-nearest-neighbor couplings are stronger in the more stable variant, indicating a network of residues that help stabilize the protein. Our study highlights the complementary benefit of charge coupling analysis to interpret protein structure¬¬¬–function relationships.
A new family of rigid C2-symmetric cleft molecules as potential medicinal chemistry scaffolds
Authors: Kimber Marc , Elgadi Gazalah , Elsegood Mark , Patel Miheal , Netz Paulo , de Oliveira Tiago
Published: June 2022

The discovery of new scaffolds that selectively interact with biomolecules (e.g. DNA) supports the development of new medicinal and chemical biology tools, such as novel therapeutics and sensors. Whilst their binding and specificity is dependent on several well established factors, there has been an increasing emphasis on identifying scaffolds that possess intrinisic 3-dimensionality. Herein, we report the synthesis, photophysical and preliminary ds-DNA binding properties of a novel series C2-symmetric carbocyclic cleft scaffolds. The synthesis of two cleft ligands has been realised through a 4-step procedure with the structures of each molecule established through single crystal X-ray crystallography. The unique 3-dimension shape of these cleft molecules has allowed for accurate positioning of extended aromatic groups, which assist in their interaction with ds-DNA. This interaction was probed through UV-Vis titration studies of the racemic ligands with ct-DNA and the preliminary studies establish that the mode-of-binding with ct-DNA is via intercalation, which is further supported using computational DNA-docking studies.
Clinicopathological analysis of 80 cases of oral lobular and non lobular capillary hemangioma (pyogenic granuloma): A Retrospective study
Authors: Shareef Karrar N , Abdullah Bashar H
Published: June 2022

Background: Oral pyogenic granuloma (PG) is a clinicopathological entity that could develop due to the reaction to a variety of stimuli, such as low-grade local irritation, traumatic damage, and hormonal stimulation. There are two histopathological types of pyogenic granuloma; lobular type -capillary hemangioma (LCH) and non-lobular type; with PG,LCH has highly vascular, diffuse capillary growth while non- lobular variant mimicking granulation tissue with heavily inflammated stroma. The study aims were to review the clinical  and histopathological spectrum of an oral pyogenic granuloma from different intraoral sites in order to avoid diagnostic pitfalls associated with similar morphological lesions and to determine whether lobular and non-lobular histopathological subtypes being  distinct entities.
Materials and Methods: A retrospective review of eighty formalin-fixed paraffin-embedded tissue blocks (40 cases each of males and females) were retrieved from the archives of Oral & Maxillofacial Pathology at the University of Baghdad, from 1979 to 2017. According to Mills  et al., criteria for lobular capillary hemangioma description, the diagnosis of each case was confirmed by the examination of Hematoxylin and Eosin stained sections by an expert pathologists.
Results:The present result revealed that patients with oral pyogenic granuloma were with age range from 12 to 59 years, with a mean of 30.57 years. Fourty nine cases (61.25%) out of eighty were of lobular pattern and 31 cases (38.7%) of non-lobular pattern type PG. The most common site of LCH was in the buccal mucosa, 12 cases (75%), while higher case numbers were observed in the 21-30 year age group. There were non-significant differences between lobular and non-lobular pattern prevalence regarding age groups and between other studied variables.
Conclusio: It has been proposed that LCH and non-LCH subtypes reflect distinct phases in the development of a single lesion, which exhibits variable degrees of proliferative, angiogenic, and inflammatory activities.
Investigating the Use of 3D-Printing in the Medical Education Curriculum in Otolaryngology: A Protocol Paper
Authors: Leung Gareth , Pickett Arthur Travis , Bartellas Michael , Milin Ariana , Bromwich Matthew , Shorr Risa , Caulley Lisa
Published: June 2022

Three-dimensional (3D) printing has been used in recent years to produce educational materials in medicine. Recent studies have found that fields such as otolaryngology may benefit from the use of 3D printing in teaching medical students and residents. Our team will conduct a systematic review to survey the current uses of 3D printing interventions in otolaryngology. We aim to assess how similar the 3D printed models are to human anatomy, their surgical utility, and educational uses.
Playing Feminine Rage: Bodies, Identities And The Performative Embodiment Of Emotions On Shakespeare’s Stage
Authors:   , Roy Priyanka
Published: June 2022

This thesis explores women’s anger in Shakespeare’s plays. Anger, and its intensive form, rage can effectively highlight women’s justified anger at unfair treatment and injustice. In the early modern period, gender and class-coded humoural theory and courtesy manuals influenced the idea of temperance in conduct, resulting in a negative view of women’s fury. The early modern discourse of anger control further marginalised women’s anger by classifying women’s righteous rage in the category of uncontrollable passions, whereas anger was seen as a normal, even necessary, emotion in men. Women’s anger can reveal vital innermost desires of women since anger propels a subject to act in a specific manner which in turn points to anger’s agential powers. The misogynistic views of women’s anger, in currency during the early modern period, need to be interrogated. Dismissing women’s anger as an overreaction or anger for anger’s sake sidelines anger’s power to initiate change and reform. It is thus imperative to study women’s anger for its feminist implications for the audience and highlight how anger is connected to women’s subjectivity and agency.

In this genre-based study, I closely examine selected Shakespearean comedies (Taming of the Shrew, Much Ado About Nothing and Measure for Measure), histories (Henry VI, Parts 1, 2, and 3 and Richard III), tragedies (Titus Andronicus, Macbeth and Antony and Cleopatra) and romances (Cymbeline, The Winter’s Tale and The Tempest) to explore how anger and rage are expressed through verbal and gestural elements in these plays. I investigate the discourse of anger control, humoural theory, early modern medical and philosophical texts and conduct literature to study how these construe women’s anger. This thesis is situated within an intersectional feminist framework, in which I have employed theoretical tools from affect theory, cognition studies, history of emotion and theatre studies, to examine the empowering qualities of women’s anger. As part of my methodology, I consider how women’s anger is represented in contemporary productions using critical elements from emotion and gesture studies. I conducted interviews with theatre practitioners from the Royal Shakespeare Company, Bell Shakespeare, American Shakespeare Center and Pop-Up Globe, and learnt the role directorial vision, actor’s interpretation and production theme play in the performance of women’s anger. I also organised a facilitated workshop through which I demonstrated how affective gestures can make visible women’s anger on stage. My original contribution to knowledge is that I posit women’s anger has agency, and demonstrate how affective gestures of anger play a critical role in revealing the loss, pain and rage of women in Shakespeare’s plays.
Petatis (Penyiram Tanaman Otomatis) guna Membentuk Pola Pikir Technopreneurship pada Siswa di Wilayah Pesisir
Authors: Nusyirwan Deny , Shah Mohamed Ezham , Perdana Prasetya Perwira Putra
Published: June 2022

Setiap desainer perlu memahami tahapan-tahapan pada proses desain rekayasa untuk menghasilkan sebuah inovasi berbasis teknologi yang merupakan solusi untuk masyarakat, selain itu perguruan tinggi juga telah melihat akan pentingnya pemahaman terhadap proses desain rekayasa untuk menghasilkan calon Technopreneur dan ilmuwan dimasa depan yang bermanfaat bagi masyarakat. Oleh sebab itu, pada paper ini akan memberikan pemahaman kepada desainer mengenai tahapan-tahapan untuk mendapatkan konsep awal perancangan sebuah teknologi yang akan dihasilkan dan prototipe yang dihasilkan juga hanya sebuah prototipe sederhana, namun sudah dapat di pergunakan untuk diuji coba bersama calon pengguna guna mendapatkan perbaikan rancangan. Berbagai permasalahan ditemukan yang menjadikan siswa malas untuk menyiram tanaman seperti jarak untuk mengambil air yang cukup jauh, siswa basah ketika menyiram tanaman, siswa merasa lelah saat mengambil air karena berat dan harus bolak balik telah menyebabkan tanaman banyak kekeringan hingga mengalami kematian. Untuk mengatasi hal ini maka diperlukan sebuah alat yang mampu menghindari tanaman mati, oleh sebab itu dirancang sebuah prototipe sederhana alat Penyiram Tanaman Otomatis (PETATIS). Apabila tanaman didekatkan maka sensor ultrasonik akan mendeteksi dan selanjutnya akan diteruskan ke Arduino, lalu arduino uno akan memberi perintah kepada relay untuk menyalakan pompa air mini. Dengan inovasi ini, diharapkan akan dapat mendorong siswa berpikir technopreuner, yaitu kreatif, inovatif dan tidak gampang menyerah, serta menumbuhkan minat siswa terhadap teknologi dan inovasi untuk mengatasi permasalahan di lingkungan sekolah.