bluuebunny/crossref_metadata_2025 huggingface dataset:
PENGARUH SUPLEMENTASI TEPUNG DAUN KELOR TERHADAP KADAR HDL DAN TRIGLISERIDA TIKUS SPRAGUE DAWLEY DISLIPIDEMIA
Authors: Rupiasa Welresna Juliatri Putri
Published: December 2022

Latar Belakang. Ketidakseimbangan metabolisme lipid dalam tubuh atau yang dikenal sebagai dislipidemia dapat menjadi pemicu berbagai penyakit kardiovaskular. Kandungan antioksidan yang tinggi dalam daun kelor dapat memperbaiki profil lipid akibat kondisi dislipidemia. Tujuan. Penelitian ini bertujuan menganalisis efek suplementasi tepung daun kelor terhadap kadar kolesterol HDL dan kadar trigliserida pada tikus Sprague Dawley yang dikondisikan dislipidemia. Metode. Penelitian ini merupakan true experiment dengan randomized pre-test and post-test with control group design. Penelitian menggunakan sampel tikus putih Sprague Dawley dengan berat 150–200 g, usia 8–12 minggu, dan kondisi tikus sehat tanpa ada cacat fisik. Sampel dibagi menjadi 4 kelompok berbeda: K-, K+, P1, dan P2. Kelompok K- adalah kelompok tikus sehat, kelompok K+ kelompok tikus yang diberi pakan tinggi lemak, kelompok P1 adalah kelompok tikus yang diberi suplementasi tepung kelor dosis 0,1 g/100 g BB dan kelompok P2 adalah kelompok tikus yang diberi suplementasi tepung kelor dosis 0,2 g/100 g BB. Sampel diteliti selama 28 hari. Pengukuran kadar kolesterol HDL dan trigliserida menggunakan metode CHOD-PAP. Uji statistik menggunakan paired t-test, one way Anova, dan Post Hoc Bonferroni. Hasil. Hasil penelitian menunjukkan kenaikan yang signifikan pada kadar kolesterol HDL serta penurunan yang signifikan pada kadar trigliserida (p=0,000). Peningkatan kadar kolesterol HDL pada kelompok P2 secara bermakna lebih tinggi dari kelompok P1. Penurunan kadar trigliserida pada kelompok P2 secara bermakna lebih besar dari kelompok P1. Hal ini dikaitkan dengan kandungan antioksidan diantaranya flavonoid, vitamin C, dan beberapa senyawa lain. Kandungan flavonoid, tanin, saponin, dan β-sitosterol mampu mengurangi akumulasi trigliserida berlebih dalam tubuh. Kandungan flavonoid dan vitamin C dapat meningkatkan aktivitas LCAT dalam membentuk kolesterol HDL. Kesimpulan. Penambahan suplementasi tepung daun kelor dapat memperbaiki profil lipid tikus dislipidemia.
HUBUNGAN TINGKAT STRES DENGAN KEJADIAN HIPERTIROID PADA WANITA USIA SUBUR
Authors: Musoddaq Muhamad Arif , Hidayat Taufiq , Samsudin Mohamad
Published: December 2022

Latar Belakang. Hipertiroid dapat mengakibatkan percepatan detak jantung, penurunan berat badan, peningkatan nafsu makan, dan kecemasan. Hipertiroidisme lebih sering terjadi pada wanita. Pajanan asap rokok, stres psikologi, penggunaan kontrasepsi hormonal, umur, periode melahirkan, dan konsumsi iodium pada tahap tertentu dapat memicu hipertiroid. Tujuan. Penelitian ini mencari hubungan antara status merokok, tingkat stres, penggunaan kontrasepsi hormonal, umur, dan penggunaan garam beriodium rumah tangga dengan kejadian hipertiroid pada wanita usia subur (WUS). Metode. Penelitian ini adalah penelitian observasional dengan desain kasus-kontrol pada pasien baru WUS berusia 15–49 tahun di Klinik GAKI Magelang tahun 2013–2014. Populasi penelitian terdiri atas kelompok kasus yaitu 51 pasien WUS didiagnosis hipertiroid. Kelompok kontrol yaitu 102 WUS yang didiagnosis sehat dan tidak mengalami gangguan fungsi tiroid (eutiroid/normal). Data dikumpulkan melalui wawancara responden disertai uji cepat kandungan iodium garam rumah tangga. Uji Chi-square dilakukan untuk mendapatkan hubungan bivariat antara variabel independen dan kejadian hipertiroid pada responden. Analisis uji regresi logistik dilakukan untuk mendapatkan hubungan variabel dependen secara bersamaan terhadap kejadian hipertiroid. Hasil. Wanita usia subur dengan stres berat mempunyai risiko hipertiroid 2,4 kali daripada WUS dengan stres ringan (OR=2,435; 95% CI=1,031–5,755; p=0,043; p<0,05). Wanita usia subur bukan pengguna kontrasepsi hormonal memiliki risiko hipertiroid 3,5 kali dibandingkan dengan WUS pengguna kontrasepsi hormonal (OR=0,284; 95% CI=0,114–0,709; p=0,007; p<0,05). Kesimpulan. Stres berat berhubungan dengan risiko hipertiroid pada WUS. Wanita usia subur (WUS) hendaknya melakukan manajemen stres sebagai salah satu upaya pencegahan terhadap hipertiroid dan juga pencegahan kekambuhan hipertiroid.
Status Resistensi Nyamuk Aedes aegypti terhadap Malation dan Mutasi Gen Ace-1 di Kota Ambon
Authors: Akollo Isak Roberth , Satoto Tri Baskoro , Umniyati Sitti Rahmah
Published: December 2022

Abstract

Aedes aegypti is the main vector of Dengue Hemorrhagic Fever (DHF). The continuous use of insecticides can cause resistant Ae. aegypti. One indicator of mosquito resistance to organophosphate is acetylcholinesterase insensitivity, which is encoded by the ace-1 gene. This study aims to analyze the status of resistance and detect ace-1 gene mutations in Ae. aegypti in Ambon city. This research is a descriptive and analytic study with a cross-sectional research design. Resistance status was tested by the CDC bottle bioassay and the detection of ace-1 gene mutations was established using PCR and sequencing. The nucleotide sequence was edited with Mega 7 software. The results of resistance tests using the CDC bottle bioassay method showed Ae. aegypti from the Waihaong and Rijali Community Health Centers had a mortality of 92% and 95.83% (tolerant), while the Latuhalat, Amahusu, Air Salobar, Benteng, Urimessing, Christina Martha Thiahahu, Karpan, Belso, Air Besar, Kilang, Halong, Lateri, Passo, and Nania had mortality between 98-100% (vulnerable). Sequencing and alignment results showed that there were no ace-1 gene mutations in Ae. aegypti originating from Waihaong and Rijali Community Health Centers. Ae. aegypti resistance status in 2 Community Health Centers is tolerant and 14 other Community Health Centers are vulnerable. There are no ace-1 gene mutations in Ae. aegypti at the Waihaong and Rijali Community Health Centers in Ambon City.

Abstrak

Nyamuk Aedes aegypti adalah vektor utama penyakit demam berdarah dengue (DBD). Penggunaan insektisida terus menerus dapat menyebabkan nyamuk Ae. aegypti resisten. Salah satu indikator resistensi nyamuk terhadap insektisida organofosfat adalah insensitivitas acetylcholinesterase, yang dikode oleh gen ace-1. Penelitian ini bertujuan menganalisis status resistensi dan mendeteksi mutasi gen ace-1 pada nyamuk Ae. aegypti di kota Ambon. Penelitian ini merupakan penelitian deskriptif dan analitik dengan rancangan penelitian cross sectional. Status resistensi diuji dengan metode CDC bottle bioassay dan deteksi mutasi gen ace-1 ditegakkan menggunakan PCR dan sekuensing. Urutan nukleotida diedit dengan software Mega 7. Hasil uji resistensi dengan metode CDC bottle bioassay menunjukan nyamuk Ae. aegypti dari Puskesmas Waihaong dan Rijali memiliki mortalitas 92% dan 95,83% (toleran), sedangkan Puskesmas Latuhalat, Amahusu, Air Salobar, Benteng, Urimessing, Chrsitina Martha Thiahahu, Karpan, Belso, Air Besar, Kilang, Halong, Lateri, Passo, dan Nania memiliki mortalitas antara 98-100% (rentan). Hasil sekuensing dan alignment menunjukan tidak terdapat mutasi gen ace-1 pada nyamuk Ae. aegypti yang berasal dari Puskesmas Waihaong dan Rijali. Status resistensi nyamuk Ae. aegypti  di 2 Puskesmas Kota Ambon tergolong toleran dan 14 Puskesmas lainnuya tergolong rentan. Tidak terdapat mutasi gen ace-1 pada nyamuk Ae. aegypti di Puskesmas Waihaong dan Rijali Kota Ambon.
Efektivitas Larvasida Infusa Daun Sirsak (Annona muricata L.) terhadap Mortalitas Larva Ae. aegypti
Authors: Salsabila Afifah Nur , Sukesi Tri Yuni
Published: December 2022

ABSTRACT

Cases of Dengue Hemorrhagic Fever (DHF) have increased more than 8 times in the last two decades (2000-2019). DHF caused by the dengue virus which transmitted through the Aedes aegypti mosquito vector. Control is a step to prevent transmission by breaking the vector life cycle, it can be with temephos. However, its use can have side effects for the environment, health and resistance to larvae. Natural larvicides are an alternative and environmentally friendly step. The purpose of this study was to determine the effectiveness of the larvicide infusion of soursop leaf (Annona muricata L.) on the mortality of Aedes aegypti larvae. The type and research design was true experiment with a posttest only control group approach. Extraction of substances in plants used the infusion method. The research samples were 25 larvae instar III Aedes aegypti per container with criteria for being able to move actively. There were 8 treatment groups in the study consisting of negative control (well water), positive control (temephos) and soursop leaf infusion with 6 concentrations (1%; 2%; 3%; 4%; 5%; 6%). Observation time was carried out for 24 hours and three times replicates. Data were analyzed by Kruskal-Wallis, Mann-Whitney and probit analysis. The results of the analysis showed the value of LC50 was 2.611% and LC90 was 4.309%. While LT50 8.467 hours and LT90 14.263 hours. The conclusion of the study showed that soursop leaf infusion (Annona muricata L.) was effective in killed Aedes aegypti larvae.

ABSTRAK 

Kasus Demam Berdarah Dengue (DBD) meningkat lebih dari 8 kali dalam dua dekade terakhir (2000-2019). DBD disebakan oleh virus dengue yang ditularkan melalui vektor nyamuk Aedes aegypri. Pengendalian menjadi langkah untuk mencegah terjadinya penularan dengan memutus siklus hidup vektor, dapat dengan temephos. Namun penggunaannya dapat memberikan efek samping baik bagi lingkungan, kesehatan dan resistensi pada larva. Larvasida alami menjadi langkah alternatif dan ramah lingkungan. Penelitian ini bertujuan untuk mengetahui efektivitas larvasida infusa daun sirsak (Annona muricata L.) terhadap mortalitas larva Aedes aegypti. Jenis dan rancangan penelitian berupa eksperimen murni pendekatan posttest only control group. Pengambilan zat dalam tanaman menggunakan metode infusa. Sampel penelitian adalah larva instar III Aedes aegypti sebanyak 25 ekor per kontainer dengan kriteria dapat bergerak aktif. Terdapat 8 kelompok perlakuan dalam penelitian yang terdiri 2dari kontrol negatif (air sumur), kontrol positif (temephos) dan infusa daun sirsak dengan 6 konsentrasi (1%; 2%; 3%; 4%; 5%; 6%). Waktu pengamatan selama 24 jam sebanyak tiga kali replikasi. Data dianalisis dengan uji Kruskal-Wallis, Mann-Whitney dan uji probit. Hasil analisis menunjukkan nilai dari LC50 adalah 2.611% dan LC90 adalah 4.309%. Sedangkan LT50 8.467 jam dan LT90 14.263 jam. Kesimpulan penelitian menunjukkan bahwa infusa daun sirsak (Annona muricata L.) efektif membunuh larva Aedes aegypti.
Persebaran Habitat Keong Perantara Schistosomiasis di Dataran Tinggi Lindu, Kabupaten Sigi, Sulawesi Tengah
Authors: Nurwidayati Anis , Widjaja Junus , Nursafingi Afi , Kurniawan Ade , Lobo Leonardo Taruk , Faozan Muhamad , Rauf Abdul
Published: December 2022

ABSTRACT

Schistosomiasis in Indonesia is caused by the trematode worm, Schistosoma japonicum, with the snail Oncomelania hupensis lindoensis as the intermediate host. The presence of these snails is an indicator of determining the habitat area for the intermediate host of schistosomiasis. The aim of the study was to map the distribution of snail habitat in the Lindu endemic area. An observational study with a cross-sectional design was conducted in August 2021. The study was conducted in two villages in the Lindu Highlands, Sigi Regency, Central Sulawesi Province. The number of snail habitats in the Lindu Plateau found 25 habitats, covering an area of ​​27,088 m2. Snail density and infection rate (IR) were found to be 27.06 snails/minute (IR 0.68%). Based on the research, it can be concluded that the distribution pattern of the snail habitat in Lindu was clustered in certain areas. Habitat in Anca Village was most widely found in neglected coffee plantation areas, and a small part in primary forest areas. Snail habitat in Tomado Village was mostly found in watersheds, parapa grass in swamp areas, and uncultivated rice fields. Environmental management that can be carried out by multi sectors are the creating of rice fields, the creation of fish ponds, and the diversion of community paths in the Lore Lindu National Park area that passes through the habitat of schistosomiasis intermediate snails.

ABSTRAK

Schistosomiasis di Indonesia disebabkan oleh cacing trematoda jenis Schistosoma japonicum dengan hospes perantara keong Oncomelania hupensis lindoensis. Keberadaan keong tersebut sebagai indikator penetapan daerah habitat hospes perantara schistosomiasis. Tujuan penelitian adalah untuk untuk memetakan distribusi habitat keong di wilayah endemis Lindu. Jenis penelitian adalah observasional dengan desain potong lintang yang dilakukan pada bulan Agustus tahun 2021. Penelitian dilakukan di Desa Anca dan Tomado Kecamatan Lindu Kabupaten Sigi, Provinsi Sulawesi Tengah. Jumlah habitat keong di Dataran Tinggi Lindu ditemukan 25 habitat, seluas 27.088 m2. Kepadatan keong dan tingkat infection rate (IR) ditemukan sebesar 27,06 keong/menit (IR 0,68%). Berdasarkan penelitian dapat disimpulkan bahwa pola persebaran habitat keong di Lindu adalah mengelompok/clustered pada daerah tertentu. Habitat di Desa Anca ditemukan paling banyak di daerah kebun kopi yang terabaikan, dan sebagian kecil di daerah hutan primer dengan kanopi tertutup. Habitat keong di Desa Tomado paling banyak ditemukan di daerah aliran air, parapa, rawa, dan sawah tidak diolah. Manajemen lingkungan yang dapat dilakukan oleh lintas sektor yaitu pencetakan sawah, pembuatan kolam ikan, dan pengalihan jalur masyarakat dalam Kawasan Taman Nasional Lore Lindu yang melewati habitat keong perantara schistosomiasis.
Pengaruh Pengobatan dan Prevalensi Infeksi Cacing Usus pada Anak Sekolah Dasar di Kecamatan Dampelas dan Kecamatan Banawa, Kabupaten Donggala, Sulawesi Tengah
Authors: Widayati Anis Nur , Sumolang Phetisya Pamela Frederika , Nurjana Made Agus , Widjaja Junus
Published: December 2022

ABSTRACT

Soil-Transmitted Helminths infection is still remain become a health problem in tropical and sub-tropical countries, one of which is Indonesia. The aim of the study was to determine the STH infection in Banawa and Dampelas sub-districts, Donggala district, Central Sulawesi Province. The study was conducted in February - November 2017 on 153 elementary school students. The collected feces were examined by the direct examination method. The results found infections of Ascaris lumbricoides, hookworm, and Trichuris trichiura. We also found Enterobius vermicularis and mixed infections. However, the logistic regression test showed there was no relationship between taking deworming medication and the incidence of worms in school childrenin Donggala Regency (p-value > 0,05). Based on the results it can be concluded that the prevalence of STH infection in both locations is still high. It is necessary to make efforts to treat school children and counseling on clean and healthy living behavior.

ABSTRAK

Infeksi Soil Transmitted Helminths masih menjadi masalah kesehatan di negara tropis dan sub tropis, termasuk di Indonesia. Tujuan penelitian adalah untuk menentukan tingkat infeksi STH pada siswa sekolah dasar (SD) wilayah Kecamatan Banawa dan Dampelas, Kabupaten Donggala, Provinsi Sulawesi Tengah. Penelitiandilakukan pada bulan Februari - November 2017 dengan jumlah sampel 153. Tinja yang terkumpul diperiksa dengan metode pemeriksaan langsung. Hasil penelitian ditemukan infeksi cacing gelang (Ascaris lumbricoides) cacing tambang (Hookworm), dan cacing cambuk (Trichuris trichiura). Selain itu ditemukan infeksi Enterobius vermicularis dan infeksi ganda. Namun uji logistic regression menunjukkan bahwa tidak ada hubungan antara minum obat cacing dengan kejadian kecacingan pada anak sekolah di Kabupaten Donggala (p-value > 0,05).Berdasarkan hasil penelitian dapat disimpulkan bahwa prevalensi infeksi STH di kedua lokasi masih tinggi. Perlu dilakukan upaya pengobatan anti cacing pada anak sekolah serta penyuluhan perilaku hidup bersih dan sehat.
Pemeriksaan Leptospirosis pada Tikus di Kecamatan Ciwidey, Kabupaten Bandung, Jawa Barat
Authors: Gunawan Gunawan , Wibowo Agus Ari , Nuridaryanto Eko Budi , Mentari Dinda Sekar , Septitiani Oka , Ningsi Ningsi
Published: December 2022

ABSTRACT

Leptospirosis is still a global health problem. Leptospirosis is caused by Leptospira bacteria and is zoonotic. This study aims to detect the presence of Leptospira bacteria in rats in Ciwidey District, Bandung Regency, West Java, using the PCR method. This research is routine surveillance conducted by the Jakarta Center for Environmental Health and Disease Control Engineering (BBTKLP) in Muncang Village, Rawabogo and Nengkelan, Ciwidey District, Bandung Regency, West Java. The activity was carried out in June 2022 using a cross-sectional research design. The results showed 46 rats caught with the species R. exulans, R. tiomanicus, R. norvegicus, M. Musculus, and Muscaroli. Success trap on the traps installed in the village of Rawabogo 1.3%, Lebak Muncang Village 2.6%, and Nengkelan 1.6%. At the same time, the results of the calculation of the average success trap obtained a value of 5.5%. The results of the PCR examination showed that 11 of 46 samples of the examined rat kidney contained the DNA of the pathogenic Leptospira. It is necessary to control rats in residential areas in Ciwidey District, Bandung Regency, West Java, to prevent the transmission of pathogenic Leptospira bacteria from rats to humans.

ABSTRAK

Leptospirosis masih menjadi masalah kesehatan global. Leptospirosis disebabkan oleh bakteri Leptospira dan bersifat zoonosis. Penelitian ini bertujuan untuk mendeteksi keberadaan bakteri Leptospira pada tikus di Kecamatan Ciwidey, Kabupaten Bandung, Jawa Barat dengan menggunakan metode PCR. Penelitian ini merupakan surveilans rutin yang dilakukan oleh Balai Besar Teknik Kesehatan Lingkungan dan Pengendalian Penyakit Jakarta (BBTKLP). Surveilans tikus dilaksanakan di Desa Muncang, Rawabogo dan Nengkelan, Kecamatan Ciwidey, Kabupaten Bandung, Jawa Barat. Kegiatan dilaksanakan pada bulan Juni tahun 2022 dengan menggunakan desain penelitian cross sectional. Hasil penelitian menunjukkan 46 tikus berhasil ditangkap dengan spesies R. exulans, R. tiomanicus, R. norvegicus, M. Musculus dan Muscaroli. success trap pada perangkap yang terpasang yaitu di Desa Rawabogo 1,3%, Desa Lebak Muncang 2,6% dan Nengkelan 1,6%.. Sedangkan hasil perhitungan Succes Trap rata rata didapatkan nilai 5,5 %. Hasil pemeriksaan PCR menunjukkan bahwa 11 dari 46 sampel ginjal tikus yang diperiksa mengandung DNA Leptospira patogen. Perlu dilakukan upaya pengendalian tikus dilingkungan pemukiman di Kecamatan Ciwidey, Kabupaten Bandung, Jawa Barat untuk mencegah transmisi bakteri Leptospira patogenik dari tikus ke manusia.
PERLINDUNGAN HUKUM TERHADAP ANAK SEBAGAI KORBAN EKSPLOITASI EKONOMI DI KOTA JAMBI
Authors: Rakhmawati Dessy , Herlina Nelly , Alissa Evalina
Published: December 2022

Riset ini memiliki maksud untuk mengetahui perlindungan hukum terhadap anak sebagai korban eksploitasi ekonomi di Kota Jambi. Mengingat di kota Jambi masih banyak ditemui anak-anak yang menjadi korban eksploitasi ekonomi mereka di suruh berjualan koran, mengamen bahkan meminta minta. Permasalah dalam riset ini yaitu Bagaimana bentuk perlindungan terhadap anak sebagai korban eksploitasi ekonomi dan apa saja kendala yang di hadapi dalam pelaksanaan perlindungan terhadap anak sebagai korban eksploitasi ekonomi di Kota Jambi? Riset ini merupakan jenis riset empiris yang artinya riset ini mendeskripsikan fakta yang terjadi di lapangan dan mengtahui efektifitas hukum positif di masyarakat, dengan memfokuskan pada informasi primer dan sekunder, dalam hal ini data yang diperoleh langsung dari masyarakat disebut data primer, sedangkan data yang diperoleh dari bahan- bahan kepustakaan adalah data sekunder. Hasil dari Riset ini menunjukan bahwa perlindungan hukum terhadap anak korban eksploitasi ekonomi dilakukan oleh Dinas Sosial, P2TP2A (Pusat Pelayanan Terpadu Pemberdayaan Perempuan dan Anak) dan Polresta  Kota Jambi dengan menyebarluaskan ketentuan perundang-undangan yang berlaku, memberikan sosialisasi, melakukan pemantauan terhadap anak yang bekerja, memberikan laporan kepada penegak hukum yang berwenang tentang kegiatan eksploitasi ekonomi, memberikan perlindungan terhadap anak korban ekslpoitasi ekonomi, memberikan sanksi  kepada yang melakukan Tindakan eksploitasi ekonomi di Kota Jambi, kemudian  kendala yang dihadapi dalam pemberian perlindungan hukum terhadap anak korban eksploitasi ekonomi yaitu kurangnya pemahaman orang tua, masyarakat dan anak-anak tentang eksploitasi ekonomi, kurangnya kepedulian atau kepekaan dalam memberikan informasi kepenegak hukum terkait kegiatan eksploitasi ekonomi serta tidak adanya panti khusus atau rumah aman anak untuk membina anak-anak yang menjadi korban eksploitasi ekonomi.
Solution of the Quadratic Integral Equation by Homotopy Analysis Method
Authors: Bairwa R.K. , Kumar Ajay
Published: December 2022

In the present paper, we derive an approximate solution of the quadratic integral equation by using the homotopy analysis method (HAM). This approach provides a solution in the form of a rapidly converging series, and it includes an auxiliary parameter that controls the series solution's convergence. We compare the HAM solution with the exact solution graphically. Additionally, an absolute error comparison between the exact and HAM solutions is performed. The findings indicate that HAM is a very straightforward and attractive approach for computation.
Revan-Nirmala Index
Authors: Kulli V.R.
Published: December 2022

In this paper, we propose the Revan-Nirmala index of a graph. Considering the Revan- Nirmala index, we propose the Revan-Nirmala exponential of a graph. We compute the Revan- Nirmala index and Revan Nirmala exponential of chloroquine, hydroxychloroquine and remdesivir.
On the Solubility of Polynomials of Degree n
Authors: Adesina Adebisi Sunday
Published: December 2022

The concepts of solvability in polynomials is highly imperative, most especially the concerned operations on the sums and the products of the roots. In this paper, an analysis of the fundamentals and the basic characterizations of the roots of polynomials was considered. This involves but is not limited to the sums as well as the products of their roots, not only those of the elementary or lower degrees but also that of any higher degree . Efforts have been intensified to state and prove certain characterizations which each case of the degrees of the polynomial must satisfy. Hence, the analysis further helps in determining of zeros for any given polynomial, including those of higher degrees.
Some Characterization of Directed Below 0-distributive Join Semilattices
Authors: Gope Rathindra Chandra
Published: December 2022

Varlet characterized the concept of 0-distributive lattices to generalize the notion of pseudo complemented lattices. Powar and Thakare introduced the notion of 0- Distributive semilattices. Very few authors have studied join semilattices. Among them Nimbhorkar and Rahemani, Akhter and Noor and Rao and Kumar have introduced the join semilattices. In this paper, we have introduced the notion of join semilattices with 0 - distributive directed below. A join semilattice S is called directed below if for any a,b ∈ S there is d ≤ a , b such that d ∈ S . Then obviously, every join semilattice with 0 is directed below
Sombor and KG-Sombor Indices of Benzenoid Systems and Phenylenes
Authors: V.R.Kulli  , Gutman Ivan
Published: December 2022

Let d(v) denote the degree of a vertex v, and d(e) the degree of an edge e. The Sombor index SO is a vertex-degree-based (VDB) topological index, equal to the sum of terms ( ) ( ) 2 2 d u d v + over all pairs of adjacent vertices u and v of the underlying molecular graph. Recently a variant of SO was put forward, the KG-Sombor index, KG, equal to the sum of terms ( ) ( ) 2 2 d u d e + where u is an endpoint of the edge e.- In this paper, we give general expressions for SO and KG of benzenoid systems and phenylenes.
Historical Development of some Fixed Point Results in Metric Space
Authors: Jha Pavan Kumar
Published: December 2022

In this paper, the historical account of fixed point results for single mapping in metric space has been provided. Though, there is a vast account of fixed point results for two or more mappings in the literature. It is mainly concentrated on single mapping due to our philosophical touch on Sthira Vindu (fixed point) and Kutastha Vindu in Vedanta philosophy.
Brasil, mostra tua cara
Authors: Chapaval Pimentel Pedro , Panke Luciana , Tesseroli Ricardo , Slongo Garcia Bruno Eduardo , Da Motta Johnny Ribas
Published: December 2022

A construção da imagem do Brasil data do seu “achamento” e evoluiu juntamente com as mudanças políticas desde então. Entretanto, pesquisas sobre a representação da imagem do País por meio de marcas de governo ainda são escassas. Para preencher essa lacuna, este trabalho explora a construção da imagem do Brasil por meio de oito marcas de governo elaboradas ao longo de trinta anos de democracia. Para atingir o objetivo deste trabalho, adotou-se uma análise exploratória de fontes primárias e uma análise amparada no estudo de elementos da sintaxe da comunicação visual. O principal achado desta pesquisa foi verificar que cada governo utiliza as marcas para promover aspirações próprias e suas visões de governo, mas todos mantêm elementos de símbolos nacionais como fio condutor em suas marcas e aspectos de Estado.
Tecnologias, cotidianos escolares e a educação crítica para as mídias
Authors: Assis Leandro , Farbiarz Alexandre
Published: December 2022

O artigo busca discutir o cotidiano escolar à luz do pensamento de Agnes Heller e Karel Kosik. Nossa proposta é fomentar os debates para uma reflexão crítica quanto à utilização das mídias digitais nas escolas a partir da Educação Crítica para as Mídias. Dessa forma, a estrutura do capítulo se orienta por apresentar a compreensão comumente empregada de que as tecnologias transformariam os cotidianos como uma inserção dos setores empresariais pautada pela manutenção do status quo. Buscando discutir a importância da interface entre a Comunicação e a Educação, sinalizamos o campo fértil para serem desenvolvidas pesquisas que rompam com o senso comum de modo a produzir uma educação que promova intervenções sociais e compreenda a lógica e a cultura da mídia retomando o cotidiano, em especial o escolar, como um espaço de reflexão dos professores.
Fotografar para esconder
Authors: Valle Marcela
Published: December 2022

A fotografia tanto revela quanto oculta. Porém, quando uma imagem é criada, presume-se que é para dar algo a ver. No caso de Li Zhensheng, fotojornalista chinês que documentou os dois lados da Revolução Cultural Proletária (1966-1976), era imperativo esconder os negativos interditos da vigilância oficial. Imagens sitiadas, que já nascem proibidas e precisam se manter nas sombras até o dia em que seja possível alcançar a luz. Foram necessárias quatro décadas de espera para que Red-color news soldier revelasse ao mundo uma verdade que até hoje os chineses são proibidos de ver. A partir da premissa de que a imagem é reserva de futuro e com base na articulação teórica de Hannah Arendt em Entre o passado e o futuro; esse artigo se propõe a refletir sobre que porvir é possível sem as guias do passado? Enquanto sustenta uma política de esquecimento, a China persiste em negar aos seus cidadãos sua preciosa herança.
Validasi Metode Penetapan Kadar Logam Kadmium (Cd) dalam Sampel Tanah Menggunakan Spektrofotometer Serapan Atom (SSA)-Nyala
Authors: Rosita Tita , Ningrum Dewi Arfina Prasetyo , Yanti Yuli , Zaekhan
Published: December 2022

Soil has an important role in life on earth because it supports plant life by providing nutrients and water as well as supporting roots. One of the chemical elements that cause pollution is cadmium. The standard method for analyzing the content of cadmium metal in the soil is using a Flame Atomic Absorption Spectrophotometer (AAS) referring to SNI 8910:2021. This method changes the weight content from one gram to five grams of sample to obtain cadmium metal levels that can be detected by the instrument. Therefore, this method needs to be validated before being used for routine analysis in the laboratory. The validation parameters are linearity, precision, accuracy, method detection limit, and robustness. The Validation results were obtained for the linearity parameter correlation coefficient value of r = 0.999, %RSD repeatability precision parameter of 1.51%, and the intermediate precision was obtained by %RSD analyst 1 : 1.51% and analyst 2 : 0.82%, accuracy parameter obtained the %recovery results were (88.73-97.01)%, the LDM parameter was obtained at 2.03 mg/kg, the robustness parameter was obtained by F-count of 1.25 and F-table of 3.40 which shows the average assay of metals Cd weighing 1, 3, 5, and 8 grams that were not significantly different. Overall, the results of the validation show that the method of assaying cadmium metal using Flame-AAS complies with the acceptance requirements, therefore it can be used for routine analysis in the laboratory.
Analisis Kadar Merkuri (Hg) pada Rambut Pekerja Tambang di Pertambangan Emas Tanpa Ijin (PETI) Kabupaten Parigi Moutong dalam Hubungannya dengan Frekuensi Konsumsi Ikan
Authors: Musafira  , Rasul Ernawaty
Published: December 2022

Illegal gold mining is a mining activity using traditional methods. Mining activities in the traditional way process mining products using the amalgamation process. In the amalgamation process, gold is bound by adding mercury and the waste from the amalgamation process which may still contain mercury is discharged into the environment. It can have an impact on the accumulation of mercury in humans, especially the miners either directly or through the food chain. This study aims to determine the amount of mercury concentration that has accumulated in miners' hair in relation to the frequency of fish consumption. The sampling method is done by random sampling method in five sub-districts in Parigi Moutong Regency. Fish consumption frequency data was taken by filling out questionnaires by respondents (miners). Analysis of mercury content in hair samples was carried out using the Mercury Analyzer NIC MA-3000. The results showed that the concentration of mercury in miners in all sub-districts exceeded the quality standard set by USEPA, which was above 1 mg/Kg. The highest mercury content was found in the miner's hair in Moutong District which was 3.48 mg/kg, while the lowest mercury content was found in the miner’s hair in Kasimbar District which was 1.06 mg/kg. Based on these results, the gold miners in the five sub-districts have been contaminated with mercury. A correlation value above 0.5 indicates a correlation between fish consumption and mercury concentrations in hair, thereby it can be said that the source of mercury exposure to miners can also come from the fish they consume.
Ekstraksi Teh Hijau dan Aplikasinya sebagai Pengendali Korosi Pada Pompa di Lingkungan Garam NaCl 3,56%
Authors: Indarti Retno
Published: December 2022

Green tea leaves contain antioxidant compounds that can be used as organic inhibitors in a corrosion process. Tea leaves were extracted by maceration method using 70% ethanol solution with a solid:solvent ratio of 1:8 (w/v) for 1 x 24 hours in an atmospheric room. The extract was then concentrated with a rotary evaporator and separated with solvent under vacuum conditions at 852 mbar, temperature of 70oC and rotation of 80 rpm. The results of the qualitative test of extra tea leaves using 10% NaOH and 1% FeCl3 changed the color to brownish orange and blue-black. This indicates the content of flavonoids and tannins. Green tea leaf extract is also applied to control the corrosion rate of brass metal. Variations in the concentration of tea leaves were 200, 400, 600 ppm in 3.56% NaCl solution. The pump circulation is carried out for 40 hours, the weight loss method is carried out every 8 hours. The average corrosion rate without inhibitor is 3.95 mmpy, the corrosion rate with 200 ppm inhibitor is 1.24 mmpy, the corrosion rate with 400 ppm inhibitor is 0.46 mmpy, the corrosion rate with 600 ppm inhibitor is 0.23 mmpy. A significant decrease in the corrosion rate occurred at a concentration of 600 ppm with an efficiency of 92.32%.
Evaluasi Kadar Senyawa Fenolat, Flavonoid Total, serta Aktivitas Antioksidan Secara in vitro dalam Ekstrak Metanol Bawang Dayak (Eleutherine palmifolia (L.) Merr
Authors: Laila Farida , Resmeliana Ika , Yulianti Wina , Supardan Atep Dian
Published: December 2022

Dayak onion bulbs are a plant originating from Kalimantan which has been used for generations to treat various diseases. This plant is quite easy to grow and develop in many places in Indonesia. The aims of the present study were to evaluate the antioxidant potential of the methanol extract of Dayak onion bulbs based on the total of the phenolic and flavonoids contents and also the antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging ability, ferric reducing power and total antioxidant capacity.  The results showed the total phenolic and flavonoid methanol extract of Dayak onion bulbs were 14.49 ± 1.42 mg GAE/g dry weight and 5.41 ± 1.01 mg QE/g dry weight, respectively. Antioxidant activity as measured by the DPPH, total antioxidant capacity, and ferric reduction assay with IC50 values of 16.95 ± 1.58 μg/mL, 24.22 ± 2.51 µg/mL, and 85.40 ± 16.88 µg/mL, respectively. These results suggest that the methanol extract of Dayak onion bulbs has potential bioactive compounds with good antioxidant activity and can be developed as an effective and safe source of natural compounds for functional food or herbal medicine.
Do hourly and seasonal changes in non-structural carbohydrates in grapevine leaves contribute to osmotic adjustment and regulation of photosynthesis?
Authors: Perry Aviad , Sperling * , Ben-Gal Alon , Holbrook N. Michele , Rachmilevitch Shimon , Hochberg Uri
Published: December 2022

Leaves maintain a pool of non-structural carbohydrates (NSC) whose size
can vary over hourly and longer timescales. We tested two long-standing
hypotheses regarding potential physiological roles of changes in foliar
NSC levels. The first is that soluble NSC play a critical role in
osmotic adjustment, with their increase enabling stomatal opening
despite daily and seasonal reductions in leaf water potential (Ψ
). The second is that increases in NSC is a sign of
excess assimilation relative to sink demand and serves as a signal to
downregulate gas exchange. To explore these questions, we monitored the
diurnal and seasonal dynamics of gas exchange, Ψ ,
osmotic potential, and NSC of irrigated and dehydrated grapevines (
Vitis vinifera) through two consecutive growing seasons. We found
that the daily accumulation of soluble sugars constitutes approximately
50% of the daily osmotic adjustment (0.2 MPa), enabling the vines to
maintain turgor under low Ψ . At the same time, the
importance of NSC as osmolytes decreased as the season progressed, and
they did not contribute to osmotic adjustment when water was withheld.
Additionally, there was no negative correlation between NSC and gas
exchange, implying that NSC are not the signal for photosynthetic
feedback inhibition.
Echocardiography in Left Atrial Thrombosis
Authors: Moghaddasfar Tara , Vahidi Hamed , Faramarzpour Maryam , Larti Farnoosh
Published: December 2022

Atrial fibrillation is associated with low-flow state and increased
thrombogenicity in the left atrium (LA). Multiple echocardiographic
presentations, including thrombosis, sludge, and smoke formation, have
been demonstrated in just one biplane transesophageal echocardiographic
view, along with normal structures, i.e., pectinate muscles and Coumadin
ridge, which are highly educational for cardiologists.
Genome protecting and genotoxic effects produced by derivatives of 1,4-dihydropyridine
Authors: Leonova Elina , Ryabokon Nadezhda , Rostoka Evita , Borisovs Vitalijs , Velena Astrida , Bisenieks Egils , Duburs Gunars , Dzintare Maija , Sjakste Nikolajs , Goncharova Roza
Published: December 2022

The review summarizes data on genome protecting and genotoxic action of
1,4-dihydropyridines (DHP) with main focus on the compounds synthesized
in the Latvian Institute of Organic synthesis. Most of these compounds
manifest very low calcium channel blocking activity, thus considered to
be “unusual” 1,4-DHP. Some of these compounds decrease spontaneous
mutagenesis and frequency of mutations induced by chemical mutagens.
Some water-soluble 1,4-DHP protect DNA against damage produced by
hydrogen peroxide, radiation and peroxynitrite. In these molecules
capability to protect DNA cohabitates with DNA-binding activity.
Possible mechanisms of above effects are discussed.
Dysregulated lipids in plasma and erythrocytes of COVID-19 patients and association with mental health
Authors: Khedr Alaa , Khayat Maan T. , Khayyat Ahdab N. , Asfour Hany Z. , Alsilmi Rahmah A. , Kammoun Ahmed K.
Published: December 2022

The lipid composition of the plasma and erythrocytes homogenate extract
of COVID-19 patients was characterized and measured by using
liquid-chromatography-ion trap mass spectrometric (LC-IT-MS). The
samples collected from COVID-19 patients also showed a significant
change in the level of lipids with the formation of a distinct pattern.
It is known that the disruption of the cellular lipid composition
facilitates the virus penetration and replication process. The most
dysregulated lipids in the plasma and erythrocytes of COVID-19 patients
included plasmenylphosphatidylethanolamines,
diacyl-glycero-phosphatidylethanolamines (PEs),
diacyl-glycero-phosphatidylcholines (PCs), arachidonic acid, some
oxylipids, and glycerophosphatidylinositols (PIs). The lipids,
arachidonic acid, and oxylipids were dysregulated by a factor ranging
from 1.4 to 4.8. The data also showed that eight major quantified PIs
were significantly decreased in the erythrocytes of patients infected
with COVID-19, including; 18:0_PI, 16:0_18:2_PI, 16:0_20:4_PI,
16:0_18:1_PI, 18:0_18:2_PI, 18:0_20:4_PI, 18:1_18:0_PI, and
18:0_20:3_PI. This dramatic dysregulation of cellular lipid structures
is known to be associated with psychological problems, imbalances in
mental health, and memory fog. The obtained data helped us to recommend
prescribing fish roe extract as a supplementary natural product as a
source of phospholipids that improve mental health and help against
depression and anxiety.
Cancer-associated Fibroblasts: Is it a key to an intricate lock of tumorigenesis?
Authors: zaheer sufian , Aden Durre , Ranga Sunil
Published: December 2022

The past few decades have witnessed a major leap in knowledge relating
to the role of tumor microenvironment in carcinogenesis and evolving
behaviour of the tumor. Multiple factors within the tumor
microenvironment modulate the cancer cells and the associated therapies.
Stephen Paget first asserted that the microenvironment plays an
important role in the growth of tumor metastasis. The most important
player in the tumor microenvironment is cancer-associated fibroblast
which significantly participates in the proliferation, invasion and
metastasis of tumor cells. Cancer-associated fibroblasts show phenotypic
and functional heterogeneity. Mostly cancer-associated fibroblasts
originate from quiescent resident fibroblast or mesoderm-derived
precursor cells (mesenchymal stem cells), although several alternate
sources of origin have been noted, however, due to a lack of specific
fibroblast-restricted markers, it is very difficult to trace lineage and
identify the biological origin of distinct sub-types of CAFs. CAFs are
predominantly shown by several studies to mainly act as tumor-promoting
agents, however, tumour-inhibiting actions are also being validated by
several studies. A more objectified and comprehensive functional and
phenotypic classification of CAF is required, which will help in better
way for tumor management. Here, in this review, we have tried to review
the current status of CAF origin, along with phenotypic and functional
heterogeneity, and recent progress in cancer-associated fibroblast (CAF)
research.
INVESTIGATION OF AGEING AND TEMPERATURE IN LITHIUM-ION CELLS USING A MARKET DEFINITION PARADIGM BALANCE VOLTAGE APPROACH
Authors: EnochOghene Samuel , Yesufu Thomas
Published: December 2022

This article presents a simplified approach for the tracking of ageing
and temperature effects in Lithium-ion cells via a balanced cell voltage
approach. This balanced cell approach is obtained from the principle of
moments of forces based on fundamental physics, in line with the market
definition paradigm. Qualitative and quantitative results obtained show
that indeed the balance voltage does track ageing and temperature
phenomena in these cells. For example, using a chemistry, a safe maximum
balance voltage of about 3.23 V while a minimum of about 3.10 V over
2000 cycles was obtained. Similar qualitative and quantitative results
were obtained tracking temperature variation effects over a single
cycle. This approach will make implementation of cell (and expectedly
battery pack) state tracking more cost effective for typical usage
scenarios.
The influence of nanoclays on the mechanical and thermal properties of rigid PIR and PUR foams
Authors: Vlasov Ruslan , Ryabova Daria , Zeynalova Sakina , Sokolov Dmitry , Ryabov Sergei
Published: December 2022

The effect of small amounts of chemically modified nanosized clays (from 0.05 to 1 %) on the morphological, physical-mechanical and thermophysical characteristics of rigid polyurethane?polyisocyanurate (PIR) and polyurethane (PUR) foams has been studied. The effect of these additives on the structure of the resulting material, the change in its compressive strength, Young?s modulus, mass loss during combustion, and thermal conductivity are evaluated. Based on the results obtained, it is noted that the addition of small amounts (up to 0.2 %) of chemically modified Cloisite 30B nanoclay effectively reduces the average cell size of nanocomposite foams, which leads to an improvement in their performance.
Elevated Adipocyte Membrane Phospholipid Saturation Does Not Compromise Insulin Signaling
Authors: Palmgren Henrik , Petkevicius Kasparas , Bartesaghi Stefano , Ahnmark Andrea , Ruiz Mario , Nilsson Ralf , Löfgren Lars , Glover Matthew S. , Andréasson Anne-Christine , Andersson Liselotte , Becquart Cécile , Kurczy Michael , Kull Bengt , Wallin Simonetta , Karlsson Daniel , Hess Sonja , Maresca Marcello , Bohlooly-Y Mohammad , Peng Xiao-Rong , Pilon Marc
Published: December 2022

Increased saturated fatty acid (SFA) levels in membrane phospholipids have been implicated in the development of metabolic disease. Here, we tested the hypothesis that increased SFA content in cell membranes negatively impacts adipocyte insulin signaling. Preadipocyte cell models with elevated SFA levels in phospholipids were generated by disrupting the ADIPOR2 locus, which resulted in a striking twofold increase in SFA-containing phosphatidylcholines and phosphatidylethanolamines, which persisted in differentiated adipocytes. Similar changes in phospholipid composition were observed in white adipose tissues isolated from the ADIPOR2-knockout mice. The SFA levels in phospholipids could be further increased by treating ADIPOR2-deficient cells with palmitic acid and resulted in reduced membrane fluidity and endoplasmic reticulum stress in mouse and human preadipocytes. Strikingly, increased SFA levels in differentiated adipocyte phospholipids had no effect on adipocyte gene expression or insulin signaling in vitro. Similarly, increased adipocyte phospholipid saturation did not impair white adipose tissue function in vivo, even in mice fed a high-saturated fat diet at thermoneutrality. We conclude that increasing SFA levels in adipocyte phospholipids is well tolerated and does not affect adipocyte insulin signaling in vitro and in vivo.
Liver-Secreted Hexosaminidase A Regulates Insulin-Like Growth Factor Signaling and Glucose Transport in Skeletal Muscle
Authors: Montgomery Magdalene K. , Bayliss Jacqueline , Nie Shuai , de Nardo William , Keenan Stacey N. , Anari Marziyeh , Taddese Amanuiel Z. , Williamson Nicholas A. , Ooi Geraldine J. , Brown Wendy A. , Burton Paul R. , Gregorevic Paul , Goodman Craig A. , Watt Kevin I. , Watt Matthew J.
Published: December 2022

Nonalcoholic fatty liver disease (NAFLD) and impaired glycemic control are closely linked; however, the pathophysiological mechanisms underpinning this bidirectional relationship remain unresolved. The high secretory capacity of the liver and impairments in protein secretion in NAFLD suggest that endocrine changes in the liver are likely to contribute to glycemic defects. We identify hexosaminidase A (HEXA) as an NAFLD-induced hepatokine in both mice and humans. HEXA regulates sphingolipid metabolism, converting GM2 to GM3 gangliosides—sphingolipids that are primarily localized to cell-surface lipid rafts. Using recombinant murine HEXA protein, an enzymatically inactive HEXA(R178H) mutant, or adeno-associated virus vectors to induce hepatocyte-specific overexpression of HEXA, we show that HEXA improves blood glucose control by increasing skeletal muscle glucose uptake in mouse models of insulin resistance and type 2 diabetes, with these effects being dependent on HEXA’s enzymatic action. Mechanistically, HEXA remodels muscle lipid raft ganglioside composition, thereby increasing IGF-1 signaling and GLUT4 localization to the cell surface. Disrupting lipid rafts reverses these HEXA-mediated effects. In this study, we identify a pathway for intertissue communication between liver and skeletal muscle in the regulation of systemic glycemic control.
Liver-secreted Hexosaminidase A regulates insulin-like growth factor signalling and glucose transport in skeletal muscle
Authors: Montgomery Magdalene K. , Bayliss Jacqueline , Nie Shuai , Nardo William de , Keenan Stacey N. , Anari Marziyeh , Taddese Amanuiel Z. , Williamson Nicholas A. , Ooi Geraldine J. , Brown Wendy A. , Burton Paul R. , Gregorevic Paul , Goodman Craig A. , Watt Kevin I. , Watt Matthew J.
Published: December 2022

Non-alcoholic fatty liver disease (NAFLD) and impaired glycaemic control are closely linked, however, the pathophysiological mechanisms underpinning this bidirectional relationship remain unresolved. The high secretory capacity of the liver and impairments in protein secretion in NAFLD suggest that endocrine changes in the liver are likely to contribute to glycaemic defects. We identify hexosaminidase A (HEXA) as a NAFLD-induced hepatokine in both mice and humans. HEXA regulates sphingolipid metabolism, converting GM2 to GM3 gangliosides; sphingolipids that are primarily localized to cell surface lipid rafts. Using recombinant murine HEXA protein, an enzymatically inactive HEXA(R178H) mutant, or adeno-associated viral vectors to induce hepatocyte-specific overexpression of HEXA, we show that HEXA improves blood glucose control by increasing skeletal muscle glucose uptake in mouse models of insulin resistance and type 2 diabetes, with these effects being dependent on HEXA’s enzymatic action. Mechanistically, HEXA remodels muscle lipid raft ganglioside composition, thereby increasing insulin-like growth factor 1 signalling and glucose transporter 4 localization to the cell surface. Disrupting lipid rafts reverses these HEXA-mediated effects. Together, this study identifies a novel pathway for inter-tissue communication between liver and skeletal muscle in the regulation of systemic glycaemic control.