bluuebunny/crossref_metadata_2025 huggingface dataset:
‘If you are feeling alone and you are not feeling safe, it impacts everything’: a mixed-methods exploration of international students’ accommodation, subjective wellbeing and mental health help-seeking
Authors: Corney Tim , du Plessis Karin , Woods Brett , Lou Catherine , Dewhurst Anita , Mawren Daveena
Published: May 2024

Background

The international education sector is important not only to Australian society, but also to the national economy. There are growing concerns about the potential wellbeing challenges facing international students in their host country, owing to acculturative stress; including loneliness, isolation and experiences of racism. Risks include poor mental health and decreased likelihood to access support due to stigma, language and cultural barriers, not knowing where to seek help, and poor mental health knowledge.

Methods

This study explored students’ perceptions of their accommodation, subjective wellbeing (through the Personal Wellbeing Index, [‘PWI’]), mental health help-seeking and individual engagement with evidence-based everyday health promotion actions (informed by the ‘5 Ways to Wellbeing’ model) through an online survey (N = 375) and three online focus groups (N = 19). A mixed-methods approach using descriptive statistics, ANOVA, regression analysis and thematic analysis, were used.

Results

The PWI of international students in the survey was observed to be substantially lower (M = 60.7) than that reported for the Australian population (M = 77.5). Accommodation impacted on wellbeing (loneliness, belonging, connectedness) in a number of different ways including through location, safety, and shared accommodation. In terms of help-seeking, international students noted a number of barriers to accessing support for mental health: cost of accessing support, language and cultural barriers, lack of information on where to find support and stigma.

Conclusions

In the discussion, implications of the findings are considered, including that more could be done to shape policy and practice in service and facility provision around wellbeing, connectedness, and help-seeking for mental health support of international students.
Unraveling the synergy: how organizational intelligence fuel soft skills and nurses’ thriving: a cross-sectional study
Authors: Atalla Amal Diab Ghanem , Mahmoud Elseesy Naglaa Abdelaziz , El-Ashry Ayman Mohamed , Sharif Loujain Saud , Mahsoon Alaa , Aljohani Wafaa Farraj , Sobhi Mohamed Samia Mohamed
Published: May 2024

Aim

Investigate the influence of organizational intelligence on the development of soft skills and the overall thriving of nurses at Alexandria Main University Hospital in Egypt.

Design

A cross-sectional descriptive design following STROBE guidelines examined the relationship between organizational intelligence, soft skills, and nurses’ thriving.

Methods and tools

Data were collected from 740 nurses working across critical care units using structured questionnaires. The questionnaires assessed organizational intelligence, soft skills, and thriving at work. Sociodemographic characteristics, including age, gender, education, and nursing experience, were also collected. Statistical analyses were used to analyze the data, including ANOVA, t-tests, Pearson correlation, and stepwise regression.

Results

The findings revealed nurses’ positive perceptions of organizational culture and documentation skills. However, areas such as measures and rewards and staff relations and communication indicated opportunities for improvement. Nurses reported high vitality levels but needed more learning opportunities at work. Significant correlations were found between demographic variables, organizational intelligence, soft skills, and thriving. Organizational intelligence demonstrated a robust positive relationship with both soft skills and thriving. Age, gender, education, and experience significantly influenced nurses’ soft skills and thriving.

Conclusion

The study highlights the importance of organizational intelligence in enhancing nurses’ professional capabilities and well-being. Addressing demographic factors and fostering a supportive work environment is crucial for optimizing nursing practice and organizational effectiveness.

Nursing implications

Insights from this study can inform targeted interventions and policy decisions to enhance nursing practice, organizational development, and healthcare outcomes in Egypt. Fostering organizational intelligence and soft skills among nurses can improve patient care, increase job satisfaction, and overall organizational success.
Development and evaluation of time-resolved rapid immunofluorescence test for detection of TSOL18 specific antibody in porcine cysticercosis infections
Authors: Zhang Dejia , Duan Rui , Liu Jing , Wang Mengqi , Yang Yi , Zhao Yongjun , Liu Mingyuan , Sun Shumin
Published: May 2024

Background

Porcine cysticercosis, a serious zoonotic parasitic disease, is caused by the larvae of Taenia solium and has been acknowledged by the World Organization for Animal Health. The current detection methods of Cysticercus cellulosae cannot meet the needs of large-scale and rapid detection in the field. We hypothesized that the immunofluorescence chromatography test strip (ICS) for detecting Cysticercus cellulosae, according to optimization of a series of reaction systems was conducted, and sensitivity, specificity, and stability testing, and was finally compared with ELISA. This method utilizes Eu3+-labeled time-resolved fluorescent microspheres (TRFM) coupled with TSOL18 antigen to detect TSOL18 antibodies in infected pig sera.

Results

ICS and autopsy have highly consistent diagnostic results (n = 133), as determined by Cohen’s κ analysis (κ = 0.925). And the results showed that the proposed ICS are high sensitivity (0.9459) with specificity (0.9792). The ICS was unable to detect positive samples of other parasites. It can be stored for at least six months at 4℃.

Conclusions

In summary, we established a TRFM-ICS method with higher sensitivity and specificity than indirect ELISA. Results obtained from serum samples can be read within 10 min, indicating a rapid, user-friendly test suitable for large-scale field detection.
Development and validation of the Trust in Multidimensional Healthcare Systems Scale (TIMHSS)
Authors: Meyer Samantha B. , Brown Patrick , Calnan Michael , Ward Paul R. , Little Jerrica , Betini Gustavo S. , Perlman Christopher M. , Burns Kathleen E. , Filice Eric
Published: May 2024

Context

The COVID-19 pandemic has reignited a commitment from the health policy and health services research communities to rebuilding trust in healthcare and created a renewed appetite for measures of trust for system monitoring and evaluation. The aim of the present paper was to develop a multidimensional measure of trust in healthcare that: (1) Is responsive to the conceptual and methodological limitations of existing measures; (2) Can be used to identify systemic explanations for lower levels of trust in equity-deserving populations; (3) Can be used to design and evaluate interventions aiming to (re)build trust.

Methods

We conducted a 2021 review of existing measures of trust in healthcare, 72 qualitative interviews (Aug-Dec 2021; oversampling for equity-deserving populations), an expert review consensus process (Oct 2021), and factor analyses and validation testing based on two waves of survey data (Nov 2021, n = 694; Jan-Feb 2022, n = 740 respectively).

Findings

We present the Trust in Multidimensional Healthcare Systems Scale (TIMHSS); a 38-item correlated three-factor measure of trust in doctors, policies, and the system. Measurement of invariance tests suggest that the TIMHSS can also be reliably administered to diverse populations.

Conclusions

This global measure of trust in healthcare can be used to measure trust over time at a population level, or used within specific subpopulations, to inform interventions to (re)build trust. It can also be used within a clinical setting to provide a stronger evidence base for associations between trust and therapeutic outcomes.
Diagnostic leukapheresis reveals distinct phenotypes of NSCLC circulating tumor cells
Authors: Rieckmann Lisa-Marie , Spohn Michael , Ruff Lisa , Agorku David , Becker Lisa , Borchers Alina , Krause Jenny , O’Reilly Roisin , Hille Jurek , Velthaus-Rusik Janna-Lisa , Beumer Niklas , Günther Armin , Willnow Lena , Imbusch Charles D. , Iglauer Peter , Simon Ronald , Franzenburg Sören , Winter Hauke , Thomas Michael , Bokemeyer Carsten , Gagliani Nicola , Krebs Christian F. , Sprick Martin , Hardt Olaf , Riethdorf Sabine , Trumpp Andreas , Stoecklein Nikolas H. , Peine Sven , Rosenstiel Philipp , Pantel Klaus , Loges Sonja , Janning Melanie
Published: May 2024

Background

Circulating tumor cells (CTCs) hold immense promise for unraveling tumor heterogeneity and understanding treatment resistance. However, conventional methods, especially in cancers like non-small cell lung cancer (NSCLC), often yield low CTC numbers, hindering comprehensive analyses. This study addresses this limitation by employing diagnostic leukapheresis (DLA) to cancer patients, enabling the screening of larger blood volumes. To leverage DLA’s full potential, this study introduces a novel approach for CTC enrichment from DLAs.

Methods

DLA was applied to six advanced stage NSCLC patients. For an unbiased CTC enrichment, a two-step approach based on negative depletion of hematopoietic cells was used. Single-cell (sc) whole-transcriptome sequencing was performed, and CTCs were identified based on gene signatures and inferred copy number variations.

Results

Remarkably, this innovative approach led to the identification of unprecedented 3,363 CTC transcriptomes. The extensive heterogeneity among CTCs was unveiled, highlighting distinct phenotypes related to the epithelial-mesenchymal transition (EMT) axis, stemness, immune responsiveness, and metabolism. Comparison with sc transcriptomes from primary NSCLC cells revealed that CTCs encapsulate the heterogeneity of their primary counterparts while maintaining unique CTC-specific phenotypes.

Conclusions

In conclusion, this study pioneers a transformative method for enriching CTCs from DLA, resulting in a substantial increase in CTC numbers. This allowed the creation of the first-ever single-cell whole transcriptome in-depth characterization of the heterogeneity of over 3,300 NSCLC-CTCs. The findings not only confirm the diagnostic value of CTCs in monitoring tumor heterogeneity but also propose a CTC-specific signature that can be exploited for targeted CTC-directed therapies in the future. This comprehensive approach signifies a major leap forward, positioning CTCs as a key player in advancing our understanding of cancer dynamics and paving the way for tailored therapeutic interventions.
EGF-like growth factors upregulate pentraxin 3 expression in human granulosa-lutein cells
Authors: Li Yuxi , Chang Hsun-Ming , Zhu Hua , Sun Ying-Pu , Leung Peter C. K.
Published: May 2024

The epidermal growth factor (EGF)-like factors, comprising amphiregulin (AREG), betacellulin (BTC), and epiregulin (EREG), play a critical role in regulating the ovulatory process. Pentraxin 3 (PTX3), an essential ovulatory protein, is necessary for maintaining extracellular matrix (ECM) stability during cumulus expansion. The aim of this study was to investigate the impact of EGF-like factors, AREG, BTC, and EREG on the expression and production of PTX3 in human granulosa-lutein (hGL) cells and the molecular mechanisms involved. Our results demonstrated that AREG, BTC, and EREG could regulate follicular function by upregulating the expression and increasing the production of PTX3 in both primary (obtained from 20 consenting patients undergoing IVF treatment) and immortalized hGL cells. The upregulation of PTX3 expression was primarily facilitated by the activation of the extracellular signal-regulated kinase 1 and 2 (ERK1/2) signaling pathway, induced by these EGF-like factors. In addition, we found that the upregulation of PTX3 expression triggered by the EGF-like factors was completely reversed by either pretreatment with the epidermal growth factor receptor (EGFR) inhibitor, AG1478, or knockdown of EGFR, suggesting that EGFR is crucial for activating the ERK1/2 signaling pathway in hGL cells. Overall, our findings indicate that AREG, BTC, and EREG may modulate human cumulus expansion during the periovulatory stage through the upregulation of PTX3.
Assessing the impact of physical activity on reducing depressive symptoms: a rapid review
Authors: Samsudin Nadia , Bailey Richard Peter , Ries Francis , Hashim Siti Nur Aafifah Binti , Fernandez Janet Ann
Published: May 2024

Context

The prevalence of depression among teenagers is a significant issue worldwide, which calls for a thorough investigation of non-drug treatments. This expedited evaluation examines 24 specifically chosen studies to clarify the correlation between physical activity depression symptoms in teenagers, undertaken following PRISMA principles.

Methods

A wide range of research methods, including longitudinal studies, surveys, and cross-sectional analyses, were used in different nations to understand the intricate relationship between physical activity, sedentary behaviours, and depression symptoms. The data-gathering methods included standardised questionnaires, accelerometer measurements, and self-report instruments.

Findings

The review highlights the crucial significance of engaging in physical activity to alleviate depression symptoms. Improved self-esteem consistently acts as a crucial intermediary between participation in physical activity and decreased rates of depression. Engaging in physical activity is a safeguard, particularly for individuals with restricted access to physical activity. In contrast, a sedentary lifestyle greatly increases the probability of developing moderate to severe symptoms of depression. Gender differences are apparent, with females being disproportionately impacted by depression. There are strong connections between engaging in physical activity and reducing symptoms of depression, which can be observed in various situations, such as participating in team sports or engaging in leisure activities.

Conclusion

This study provides insight into the potential of physical activity as a non-pharmacological approach to address adolescent depression. This highlights the significant impact of physical activity, which has important implications for public health programs aimed at improving the mental well-being of adolescents by promoting physical activity. It is crucial to do additional research that considers gender-specific variations and various physical activity circumstances to enhance our comprehension of this important matter.
A mobile edge computing-focused transferable sensitive data identification method based on product quantization
Authors: Zhao Xinjian , Yuan Guoquan , Qiu Shuhan , Xu Chenwei , Wei Shanming
Published: May 2024

Sensitive data identification represents the initial and crucial step in safeguarding sensitive information. With the ongoing evolution of the industrial internet, including its interconnectivity across various sectors like the electric power industry, the potential for sensitive data to traverse different domains increases, thereby altering the composition of sensitive data. Consequently, traditional approaches reliant on sensitive vocabularies struggle to adequately address the challenges posed by identifying sensitive data in the era of information abundance. Drawing inspiration from advancements in natural language processing within the realm of deep learning, we propose a transferable Sensitive Data Identification method based on Product Quantization, named PQ-SDI. This innovative approach harnesses both the composition and contextual cues within textual data to accurately pinpoint sensitive information within the context of Mobile Edge Computing (MEC). Notably, PQ-SDI exhibits proficiency not only within a singular domain but also demonstrates adaptability to new domains following training on heterogeneous datasets. Moreover, the method autonomously identifies sensitive data throughout the entire process, eliminating the necessity for human upkeep of sensitive vocabularies. Extensive experimentation with the PQ-SDI model across four real-world datasets, resulting in performance improvements ranging from 2% to 5% over the baseline model and achieves an accuracy of up to 94.41%. In cross-domain trials, PQ-SDI achieved comparable accuracy to training and identification within the same domain. Furthermore, our experiments showcased the product quantization technique significantly reduces the parameter size by tens of times for the subsequent sensitive data identification phase, particularly beneficial for resource-constrained environments characteristic of MEC scenarios. This inherent advantage not only bolsters sensitive data protection but also mitigates the risk of data leakage during transmission, thus enhancing overall security measures in MEC environments.
Prevalence estimates of Opisthorchis viverrini and Clonorchis sinensis infection in the Greater Mekong subregion: a systematic review and meta-analysis
Authors: Sota Pornphutthachat , Andityas Morsid , Kotepui Manas , Sripa Banchob
Published: May 2024

Background

Opisthorchiasis and clonorchiasis, caused by Opisthorchis viverrini and Clonorchis sinensis, respectively, are significant yet neglected foodborne trematodiases in the Great Mekong Subregion (GMS). Despite the reporting of the prevalence of these human liver flukes in the region over the past decades, there has been a lack of a comprehensive and systematic consolidation of this data. Therefore, we aimed to conduct a thorough systematic review and meta-analysis to synthesize and analyze time-trend prevalence estimates of both O. viverrini and C. sinensis across the GMS for the past 30 years.

Methods

This study undertakes a systematic review using a comprehensive search for published articles in PubMed, EMBASE, Scopus, Cochrane and Thai Journal Online databases until early 2023. The pooled prevalence of O. viverrini and C. sinensis infection was analyzed through a random-effects meta-analysis, with meta-regression analysis used to quantify associations with study characteristics. Sub-group analysis was conducted, whenever comparison data were available, to assess the risk of O. viverrini and C. sinensis infection in each GMS country. Heterogeneity among studies was assessed using the Q statistic and quantified by using the I2 Index.

Results

From a total of 2997 articles, 155 articles comprising 218 datasets and 751,108 participants were included for review. The GMS prevalence of O. viverrini was 21.11% [45,083/260,237; 95% confidence interval (CI): 17.74–24.47%]. Pooled prevalence estimates were highly observed in Laos (34.06%, 95% CI: 26.85–41.26%), followed by Thailand (18.19%, 95% CI: 13.86–22.51%), and Cambodia (10.48%, 95% CI: 5.52–15.45%). Myanmar and Vietnam had limited data sources for calculation. Clonorchis sinensis infection in GMS was 25.33% (95% CI: 18.32–32.34%), with Guangxi, China, exhibiting the highest prevalence rates at 26.89% (95% CI: 18.34–35.43%), while Vietnam had a prevalence rate of 20.30% (95% CI: 9.13–31.47%). O. viverrini prevalence decreased significantly over time, whereas C. sinensis infection appeared to be stable consistently over time in both China and Vietnam.

Conclusions

This comprehensive study, drawing from the largest datasets to date, offers an in-depth systematic prevalence review of human liver flukes in the Greater Mekong Subregion. It underscores the imperative for systematic surveillance, data collection, and the implementation of intervention and control measures for these infectious diseases of poverty.

Graphical Abstract
Analysis of college students' attitudes toward the use of ChatGPT in their academic activities: effect of intent to use, verification of information and responsible use
Authors: Acosta-Enriquez Benicio Gonzalo , Arbulú Ballesteros Marco Agustín , Huamaní Jordan Olger , López Roca Carlos , Saavedra Tirado Karina
Published: May 2024

Background

In recent years, the use of artificial intelligence (AI) in education has increased worldwide. The launch of the ChatGPT-3 posed great challenges for higher education, given its popularity among university students. The present study aimed to analyze the attitudes of university students toward the use of ChatGPTs in their academic activities.

Method

This study was oriented toward a quantitative approach and had a nonexperimental design. An online survey was administered to the 499 participants.

Results

The findings of this study revealed a significant association between various factors and attitudes toward the use of the ChatGPT. The higher beta coefficients for responsible use (β=0.806***), the intention to use frequently (β=0.509***), and acceptance (β=0.441***) suggested that these are the strongest predictors of a positive attitude toward ChatGPT. The presence of positive emotions (β=0.418***) also plays a significant role. Conversely, risk (β=-0.104**) and boredom (β=-0.145**) demonstrate a negative yet less decisive influence. These results provide an enhanced understanding of how students perceive and utilize ChatGPTs, supporting a unified theory of user behavior in educational technology contexts.

Conclusion

Ease of use, intention to use frequently, acceptance, and intention to verify information influenced the behavioral intention to use ChatGPT responsibly. On the one hand, this study provides suggestions for HEIs to improve their educational curricula to take advantage of the potential benefits of AI and contribute to AI literacy.
Effect isolated lactic acid bacteria inoculation on the quality, bacterial composition and metabolic characterization of Caragana korshinskii silage
Authors: Bai Baochao , Qiu Rui , Sun Lin , Bao Jian , Liu Yichao , Ge Gentu , Jia Yushan , Wang Zhijun
Published: May 2024

Feed shortage has hindered the development of the world’s livestock industry, and the rational use of non-conventional forages can help resolve this issue. To improve the fermentation quality of Caragana korshinskii silage, this study isolated lactic acid bacteria (LAB) from fresh Caragana korshinskii and silage samples, as alternatives to traditional commercial LAB inoculants. Utilizing Single Molecule, Real-Time (SMRT) sequencing technology and metabolomics analysis, the microbial community structure and metabolome were examined after 60 days of fermentation to elucidate the mechanism by which isolated LAB affect the fermentation quality of Caragana korshinskii silage. After 60 days of ensiling, the dominant microbial population in the silage shifted from harmful bacteria such as Erwinia, Pantoea, and Enterobacter to LAB. Compared to commercial LAB, the isolated Lactiplantibacillus plantarum significantly reduced the microbial diversity of Caragana korshinskii silage. The species composition of LAB became simpler with Lentilactobacillus parakefiri dominating and achieving a higher relative abundance. By down-regulating Butanoate metabolism and the Pentose phosphate pathway and up-regulating the Ascorbate and aldarate metabolism pathway, the isolated Lactiplantibacillus plantarum significantly lowered the pH of the silage, increased the content of water-soluble carbohydrates (WSC) and lactic acid (LA), reduced the neutral detergent fiber content (NDF), and improved in vitro neutral detergent fiber digestibility (IVNDFD), thereby enhancing the fermentation quality of Caragana korshinskii silage. On the other hand, the isolated Limosilactobacillus fermentum had the opposite effect, with its ensiling outcome being less effective than that of commercial LAB. The results of the study indicate that the addition of the isolated Lactiplantibacillus plantarum improved the quality of Caragana korshinskii silage by regulating metabolic pathways and the composition of microbes within the ensiled feed.

Graphical Abstract
Can linezolid be validly measured in endotracheal aspiration in critically ill patients? A proof-of-concept trial
Authors: Rebholz Diana , Liebchen Uwe , Paal Michael , Vogeser Michael , Starp Johannes , Gräfe Caroline , Brozat Clara I. , Happich Felix L. , Habler Katharina , Scharf Christina
Published: May 2024

Background

Therapeutic drug monitoring (TDM) of anti-infectives such as linezolid is routinely performed in blood of intensive care unit (ICU) patients to optimize target attainment. However, the concentration at the site of infection is considered more important for a successful therapy. Until now, bronchoalveolar lavage (BAL) is the gold standard to measure intrapulmonary concentrations of anti-infective agents. However, it is an invasive method and unsuitable for regular TDM. The aim of this proof-of-concept study was to investigate whether it is possible to reliably determine the intrapulmonary concentration of linezolid from endotracheal aspiration (ENTA).

Methods

Intubated ICU patients receiving 600 mg intravenous linezolid twice daily were examined in steady state. First, preliminary experiments were performed in six patients to investigate which patients are suitable for linezolid measurement in ENTA. In a second step, trough and peak linezolid concentrations of plasma and ENTA were determined in nine suitable patients.

Results

Linezolid can validly be detected in ENTA with viscous texture and > 0.5 mL volume. The mean (SD) linezolid trough concentration was 2.02 (1.27) mg/L in plasma and 1.60 (1.36) mg/L in ENTA, resulting in a median lung penetration rate of 104%. The mean (SD) peak concentration in plasma and ENTA was 10.77 (5.93) and 4.74 (2.66) mg/L.

Conclusions

Linezolid can validly be determined in ENTA with an adequate texture and volume. The penetration rate is comparable to already published BAL concentrations. This method might offer a simple and non-invasive method for TDM at the site of infection “lung”. Due to promising results of the feasibility study, comparison of ENTA and BAL in the same patient should be investigated in a further trial.
Integrating depth-dependent protist dynamics and microbial interactions in spring succession of a freshwater reservoir
Authors: Mukherjee Indranil , Grujčić Vesna , Salcher Michaela M. , Znachor Petr , Seďa Jaromír , Devetter Miloslav , Rychtecký Pavel , Šimek Karel , Shabarova Tanja
Published: May 2024

Background

Protists are essential contributors to eukaryotic diversity and exert profound influence on carbon fluxes and energy transfer in freshwaters. Despite their significance, there is a notable gap in research on protistan dynamics, particularly in the deeper strata of temperate lakes. This study aimed to address this gap by integrating protists into the well-described spring dynamics of Římov reservoir, Czech Republic. Over a 2-month period covering transition from mixing to established stratification, we collected water samples from three reservoir depths (0.5, 10 and 30 m) with a frequency of up to three times per week. Microbial eukaryotic and prokaryotic communities were analysed using SSU rRNA gene amplicon sequencing and dominant protistan groups were enumerated by Catalysed Reporter Deposition-Fluorescence in situ Hybridization (CARD-FISH). Additionally, we collected samples for water chemistry, phyto- and zooplankton composition analyses.

Results

Following the rapid changes in environmental and biotic parameters during spring, protistan and bacterial communities displayed swift transitions from a homogeneous community to distinct strata-specific communities. A prevalence of auto- and mixotrophic protists dominated by cryptophytes was associated with spring algal bloom-specialized bacteria in the epilimnion. In contrast, the meta- and hypolimnion showcased a development of a protist community dominated by putative parasitic Perkinsozoa, detritus or particle-associated ciliates, cercozoans, telonemids and excavate protists (Kinetoplastida), co-occurring with bacteria associated with lake snow.

Conclusions

Our high-resolution sampling matching the typical doubling time of microbes along with the combined microscopic and molecular approach and inclusion of all main components of the microbial food web allowed us to unveil depth-specific populations’ successions and interactions in a deep lentic ecosystem.
Bibliometric study on organizational resilience: trends and future research agenda
Authors: Mhlanga David , Dzingirai Mufaro
Published: May 2024

In an increasingly volatile, uncertain, complex, and ambiguous (VUCA) world, the importance of organizational resilience has grown, yet the scholarly literature on this topic remains fragmented. To address this gap, our study conducted a bibliometric analysis of 469 articles from the Scopus database using VOSViewer software to systematically review and map trends, gaps, and significant contributions in the field. Our analysis revealed key themes such as resilience, crisis management, innovation, COVID-19, dynamic capabilities, sustainability, and change management, which are crucial to understanding organizational resilience. The findings highlight that the United Kingdom and the University of Oulu are significant contributors to this research area, with notable authors including Duchek E., Martinelli E., Santoro G., Williams T.A., and Youssef C.M. playing a pivotal role in advancing this field. By providing a comprehensive overview of institutional affiliations, countries, authors, journals, publications, and keyword co-occurrences, our study not only maps the landscape of organizational resilience research but also identifies critical areas for future inquiry. This contribution enhances both theoretical and practical understandings of organizational resilience, aiding practitioners in developing robust strategies to navigate the challenges of the VUCA world.
Translational simulation revisited: an evolving conceptual model for the contribution of simulation to healthcare quality and safety
Authors: Brazil Victoria , Reedy Gabriel
Published: May 2024

The simulation community has effectively responded to calls for a more direct contribution by simulation to healthcare quality and safety, and clearer alignment with health service priorities, but the conceptual framing of this contribution has been vague. The term ‘translational simulation’ was proposed in 2017 as a “functional term for how simulation may be connected directly with health service priorities and patient outcomes, through interventional and diagnostic functions” (Brazil V. Adv Simul. 2:20, 2017). Six years later, this conceptual framing is clearer. Translational simulation has been applied in diverse contexts, affording insights into its strengths and limitations. Three core concepts are identifiable in recently published translational simulation studies: a clear identification of simulation purpose, an articulation of the simulation process, and an engagement with the conceptual foundations of translational simulation practice. In this article, we reflect on current translational simulation practice and scholarship, especially with respect to these three core concepts, and offer a further elaborated conceptual model based on its use to date.
Comparative study of the reptilian cornea's microstructure
Authors: Abdelftah Zeinab , Ragab Ahmed , Abo-Eleneen Rasha E. , Abuelsaad Abdelaziz S. , EL-Bakry Ahlam M.
Published: May 2024

Background

The cornea of various vertebrate is considered a major part in the glop, which acts as a powerful lens, providing a sharp retinal image, and meantime acts as an excellent defensor for other corneal layers.

Results

The four reptilian families [Scincidae (Chalcides ocellatus); Chamaeleontidae (Chameleon chameleon); Cheloniidae (Chelonia mydas) and Testudiniae (Testudo kleinmanni)] investigated in the current study were gathered across Egypt. After being taken out of the orbit, the cornea under inquiry was ready for light, specific stain and scanning electron microscopy. The epithelium, stroma, and endothelium are the three corneal layers that are common to all four species of reptiles. All other species lack Bowmen's and Descemet's membranes, with the exception of C. ocellatus and T. kleinmanni. The latter layers of Chalcides ocellatus display a strong affinity for Periodic Acid Schiff stain. Epithelial cells with a variety of forms, from hexagonal to atypical polygonal cells, cover the outer corneal surface. These epithelial cells are coated in short microplicae, microvilli, and microholes of varied diameters. There are a few blebs scattered around their surface.

Conclusion

The current study concluded that various habitats have various significant effects on the cornea's microstructure characteristics and its physiological trends to accommodate different environmental surroundings.
Association of auditory processing abilities and employment in young women
Authors: Sharma Yoshita , K.V. Nisha
Published: May 2024

Background

This study aimed to investigate the relationship between employment status and auditory processing abilities in women, considering the cognitive impact of work-related demands. The objective was to study the influence of employment on forward -, backward -, operation span, 2n back, and speech perception in noise (SPIN) scores.

Methods

Fifty-eight women aged 20 to 64 years were categorized into working and non-working groups. Auditory cognitive assessments included forward and backward digit span, auditory 2n-back, operational span, and speech perception in noise. Mental workload, listening effort, and fatigue levels were evaluated for each test using standardized scales. Handedness was assessed using the Edinburgh Handedness Inventory. Statistical analysis involved Mann–Whitney tests and effect size calculations.

Results

Working women scored significantly higher in 2n-back task compared to non-working counterparts, emphasizing the positive impact of employment on working memory and cognitive control processes. The working women group perceptually rated greater mental load on the operational span task than non-working group, indicating the task-specific manifestation of group differences. When the tasks are easier (2n back) or difficult (operation span), employed women exhibited an advantage in auditory processing over their counterparts.  

Conclusion

This study reveals nuanced cognitive differences influenced by employment status in women. Working women demonstrated superior auditory processing abilities, specifically in working memory tasks, suggesting potential cognitive benefits associated with engagement in the workforce. The elevated mental workload for dual task working memory paradigms underscores the complexity of simultaneous processing and storage, highlighting cognitive challenges in specific occupational contexts.
A systematic review of telemedicine for neuromuscular diseases: components and determinants of practice
Authors: Senyel Deniz , Senn Katja , Boyd James , Nagels Klaus
Published: May 2024

Introduction

Neuromuscular diseases (NMDs) entail a group of mostly inherited genetic disorders with heterogeneous phenotypes impacting muscles, the central or peripheral nervous system. They can lead to severe disabilities and shortened lifespans. Despite their severity, NMDs often lack in public awareness and appropriate medical and social support. Telemedicine can improve patients’ and caregivers’ lives by enhancing continuity of and access to care. The first aim of this systematic review was to summarise the status quo of telemedicine services for patients with NMDs. Secondly, barriers and facilitators of the respective implementation processes should be analysed.

Methods

The databases PubMed, Web of Science and CENTRAL by Cochrane were searched in May 2022. To be truly explorative, any original evidence from any setting was included. Two independent researchers completed the screening process. Data was extracted and analysed using the taxonomy of Bashshur et al. (2011) and the Consolidated Framework for Implementation Research (CFIR).

Results

Fifty-seven original papers were included in the systematic review. The results showed a high representation of teleconsultations and remote monitoring studies. Teleconsultations replaced in person appointments and telemonitoring mostly focused on ventilation. Physical therapy, pulmonology, neurology, and psychology were the most represented medical specialties. We found barriers and facilitators relating to implementation mainly referred to the intervention and the individuals involved. Technical errors and inaccessibility due to a lack of technical devices or the patient’s disability were stated as hindrances. A positive mindset of users as well as patient empowerment were necessary for the adoption of new technology. Technophobia or uncertainty around technology negatively impacted the implementation process.

Discussion

This systematic review provides an overview of the current use of telemedicine in patients with NMDs. The distribution of telemedicine interventions between the defined domains was very heterogenous. Previous research has neglected to fully describe the implementation process of telemedicine for NMDs.

Conclusion

The evidence shows that telemedicine can benefit patients with NMDs in a multitude of ways. Therefore, health policies should endorse and incentivise the uptake of telemedicine by institutions and health care workers. Further research needs to be conducted to confirm the current evidence and close existing research gaps.
Moderate Associations Between the Use of Levonorgestrel-releasing Intrauterine Device and Metabolomics Profile
Authors: Toffol Elena , Heikinheimo Oskari , Jousilahti Pekka , Lehtoranta Lara , Joensuu Anni , Partonen Timo , Erlund Iris , Haukka Jari
Published: May 2024

Context

Use of a levonorgestrel-releasing intrauterine device (LNG-IUD) has become common irrespective of age and parity. To date, only a few studies have examined its possible metabolic changes and large-scale biomarker profiles in detail and in a longitudinal design.

Objective

To apply the metabolomics technique to examine the metabolic profile associated with the use of LNG-IUD both in a cross-sectional and a longitudinal design.

Design

The study consists of cross-sectional and longitudinal analyses of a population-based survey (Health 2000) and its 11-year follow-up (Health 2011). All participants aged 18 to 49 years with available information on hormonal contraceptive use and metabolomics data (n = 1767) were included. Altogether 212 metabolic measures in LNG-IUD users (n = 341) were compared to those in non-users of hormonal contraception (n = 1426) via multivariable linear regression models. Participants with complete longitudinal information (n = 240) were divided into continuers, stoppers, starters, and never-user groups, and 11-year changes in levels of each metabolite were compared.

Results

After adjustment for covariates, levels of 102 metabolites differed in LNG-IUD current users compared to non-users of hormonal contraception (median difference in biomarker concentration: –0.12 SD): lower levels of fatty acids concentrations and ratios, cholesterol, triglycerides and other lipids, as well as particle concentration, cholesterol, total lipids, and phospholipids in lipoproteins. The 11-year metabolic changes did not differ in relation to changes in LNG-IUD use.

Conclusion

The use of LNG-IUD was associated with several moderate metabolic changes, mostly suggestive of a reduced arterial cardiometabolic risk. Changes in LNG-IUD use were not related to long-term metabolic changes.
Interrogating Estrogen Signaling Pathways in Human ER-Positive Breast Cancer Cells Forming Bone Metastases in Mice
Authors: Cheng Julia N , Frye Jennifer B , Whitman Susan A , Ehsani Sima , Ali Simak , Funk Janet L
Published: May 2024

Breast cancer bone metastases (BMET) are incurable, primarily osteolytic, and occur most commonly in estrogen receptor-α positive (ER+) breast cancer. ER+ human breast cancer BMET modeling in mice has demonstrated an estrogen (E2)-dependent increase in tumor-associated osteolysis and bone-resorbing osteoclasts, independent of estrogenic effects on tumor proliferation or bone turnover, suggesting a possible mechanistic link between tumoral ERα-driven osteolysis and ER+ bone progression. To explore this question, inducible secretion of the osteolytic factor, parathyroid hormone–related protein (PTHrP), was utilized as an in vitro screening bioassay to query the osteolytic potential of estrogen receptor- and signaling pathway–specific ligands in BMET-forming ER+ human breast cancer cells expressing ERα, ERß, and G protein–coupled ER. After identifying genomic ERα signaling, also responsibility for estrogen's proliferative effects, as necessary and sufficient for osteolytic PTHrP secretion, in vivo effects of a genomic-only ER agonist, estetrol (E4), on osteolytic ER+ BMET progression were examined. Surprisingly, while pharmacologic effects of E4 on estrogen-dependent tissues, including bone, were evident, E4 did not support osteolytic BMET progression (vs robust E2 effects), suggesting an important role for nongenomic ER signaling in ER+ metastatic progression at this site. Because bone effects of E4 did not completely recapitulate those of E2, the relative importance of nongenomic ER signaling in tumor vs bone cannot be ascertained here. Nonetheless, these intriguing findings suggest that targeted manipulation of estrogen signaling to mitigate ER+ metastatic progression in bone may require a nuanced approach, considering genomic and nongenomic effects of ER signaling on both sides of the tumor/bone interface.
Review of marine alien isopods in Türkiye with two new records: of Paracerceis sculpta and Paranthura japonica
Authors: DAĞLI ERTAN , BAKIR KEREM , GÜNDEĞER GIZEM , NERLOVIC VEDRANA , DOĞAN ALPER
Published: May 2024

This study focuses on the alien isopod species recorded in the Turkish seas. To date, two alien species (Paradella dianae, Sphaeroma walkeri) have been reported in the country, accounting for almost 2.4% of the total number of isopod species occurring in the Turkish seas. The faunistic analysis of benthic samples collected from Dardanelles (Çanakkale) Straits and Izmir Bay revealed two new alien isopod species (Paranthura japonica and Paracerceis sculpta), on the Turkish coasts. Additionally, this is the first record of P. japonica in the Black Sea ecosystem. This study analyses and discusses the morphological, ecological and distributional characteristics of the species.
Διαδικασία και καλές πρακτικές για τη δημιουργία ενός βίντεο Talking head για τα MOOCs
Authors: Γιασιράνης Στέφανος , Σοφός Αλιβίζος
Published: May 2024

Τα βίντεο αρχίζουν να αξιοποιούνται με διάφορους τρόπους στην εκπαίδευση με ποιο πρόσφατο στα Μαζικά Ανοικτά Διαδικτυακά Μαθήματα (MOOCs) όπου αποτελούν το βασικό εκπαιδευτικό υλικό. Στην παρούσα εργασία, που μπορεί να αποτελέσει χρήσιμο οδηγό για σχεδιαστές μαθημάτων MOOCs, παρουσιάζονται τα διάφορα στυλ (τύποι) και τα χαρακτηριστικά των βίντεο που χρησιμοποιούνται στα MOOCs, ο ρόλος τους και ο τρόπος αξιοποίησής τους κατά τη διάρκεια των μαθημάτων. Επίσης, γίνεται καταγραφή των παραγόντων που επηρεάζουν την ποιότητά τους, σύμφωνα με τη βιβλιογραφία και αναφέρονται η διαδικασία και καλές πρακτικές για τη δημιουργία ποιοτικών βίντεο. Τέλος, παρουσιάζονται αναλυτικά τα στάδια, οι επιμέρους εργασίες και οι χρόνοι που απαιτούνται για τη δημιουργία ενός πρωτότυπου βίντεο του τύπου Talking head.
Οικογενειακές γλωσσικές πολιτικές Αλβανών μεταναστών: το σύνθετο τοπίο της γλωσσικής χρήσης ανάμεσα σε γονείς και παιδιά
Authors: Χατζηδάκη Ασπασία , Τζωρτζινάκη Δήμητρα
Published: May 2024

Τhe paper presents a small-scale study on eight families of Albanian immigrants living in Crete, Greece, and their family language policies. The study draws from Bernard Spolsky’s framework and more recent approaches which foreground the children’s agency in shaping the family’s language policies. Our findings corroborate previous research among Albanian families in Greece showing that despite the dominance of the Greek language among second-generation speakers, the ethnic language is still very much in use in many families. In this paper we focus on the various patterns which arise with regard to communication between parents and children and on the ways in which the children’s language dominance and preference seem to interfere with the parents’ desires to maintain the ethnic language at home.
Case Report: Branch retinal vein occlusion following COVID-19 vaccination and SARS-CoV-2 infection while taking oral contraceptives
Authors: Muto Tetsuya , Sakamoto Masaaki , Machida Shigeki , Imaizumi Shinichiro , Hamada Yoshinobu , Kamoi Koju
Published: May 2024

Oral contraceptive use, vaccination for Coronavirus disease 2019 (COVID-19), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are risk factors for venous thromboembolism. Branch retinal vein occlusion (BRVO) generally develops mid-60s patients. Herein, we present a case of BRVO caused by the above mentioned risk factors in a young woman. To the best of our knowledge, this is the first report about BRVO associated with oral contraceptives, COVID-19 vaccination, and SARS-CoV-2. A 21-year-old woman presented with loss of visual acuity in her right eye for 10 days. She had been receiving oral contraceptives for 2 years for oligomenorrhea before noticing ophthalmological symptoms. Despite having received two doses of an mRNA COVID-19 vaccine, she contracted COVID-19 and developed fever, sore throat, cough, low back pain, and general malaise about 40 days before the initial visit. However, only cough persisted for more than a month. The right eye showed BRVO with macular edema (ME). She did not smoke nor had diabetes or hypertension. Blood test results, including cardiolipin antibody IgG, were normal. She was treated with an intravitreal aflibercept injection. ME in the fundus showed rapid improvement and resolution. Although more than 20 months have passed since the first injection, there has been no relapse of ME. The combination of oral contraceptive use, COVID-19 vaccination, and subsequent SARS-CoV-2 infection could induce the development of venous thromboembolism, thereby leading to BRVO. Given that cases of COVID-19 have increased globally, patients with retinal vein occlusion who use oral contraceptives are likely to be encountered more frequently.