bluuebunny/crossref_metadata_2025 huggingface dataset:
TGF-β controls stromal telomere length through epigenetic modifications
Authors: Mishra Rajeev , Haldar Subhash , Biondi Rajeev , Bhari Vikash Kumar , Singh Gyanendra , Bhowmick Neil A.
Published: June 2022

Telomere length is primarily controlled by the enzyme telomerase, but being chromatin structures, telomeres undergo epigenetic regulation for their maintenance and function. Altered telomere length among cancer cells combined with shorter telomere length in cancer-associated stromal cells, strongly implicated with progression to prostate cancer metastasis and cancer death and providing a novel target for therapeutics. Transforming growth factor-β (TGF-β) signaling pathways are well-recognized for their role in stromal-epithelial interactions responsible for prostate androgen responsiveness, promoting tumorigenesis. However, the underlying mechanism remains still unclear. We sought to establish a role for TGF-ß in the regulation of telomere length in mouse and human prostate fibroblast. Polymerase chain reaction (PCR)-based telomere length measuring methods are widely used due to their repeatability and reproducibility. Using real-time RT-PCR based telomere length measuring method, we identified that TGF-beta regulates telomere length via increased expression of histone methyltransferase, Suv39h1, which in turn affected histone methylation levels at the telomeric ends. Moreover, treatment of DAPT and non-steroidal antiandrogen bicalutamide demonstrated that notch and androgen signaling co-operated with TGF-ß in regulating stromal telomere length. Telomere variation in tumor cells and non-tumor cells within the tumor microenvironment greatly facilitates the clinical assessment of prostate cancer; therefore, understanding stromal telomere length regulation mechanism will hold significant prospects for cancer treatment, diagnosis, and prognosis.
Comprehensive analysis to identify GNG7 as a prognostic biomarker in lung adenocarcinoma correlating with immune infiltrates
Authors: Wei Qin , Miao Tianshu , Zhang Pengju , Jiang Baodong , Yan Hua
Published: June 2022

Background:
G Protein Subunit Gamma 7 (GNG7) has been reported to be down-regulated in a variety of tumors including lung adenocarcinoma (LUAD). However, the correlation between GNG7 and the prognosis as well as the immune infiltrates of LUAD remains unclear.
Methods:
GNG7 expression and its prognostic value in LUAD were assessed through statistically analyzing the data from different databases. A nomogram was constructed to predict the impact of GNG7 on prognosis. Gene set enrichment analysis (GSEA) and single-sample gene set enrichment analyses GSEA (ssGSEA) were employed to determine the potential signal pathways and evaluated the immune cell infiltration regulated by GNG7. The prognostic significance of GNG7 expression associated with immune cell infiltration was investigated using the TIMER2.0 and the K-M plotter database. The UALCAN, cBioPortal and MethSurv database were used to analyze the correlation between the methylation of GNG7 and its mRNA expression as well as prognostic significance.
Results:
GNG7 was demonstrated to be down-regulated in LUAD and its low expression was associated with poor prognosis. A clinical reliable prognostic-predictive model was constructed. Pathway enrichment showed that GNG7 was highly related to the B cell receptor signaling pathway. Further analysis showed that GNG7 was positively associated with B cell infiltration and low levels of B cell infiltration tended to associate with worse prognosis in patients with low GNG7 expression. Moreover, methylation analysis suggested hypermethylation may contribute to the low expression of GNG7 in LUAD.
Conclusion:
GNG7 may be a promising prognostic biomarker and a potential immunotherapeutic target for LUAD.
Low cervical vertebral CT value increased early subsidence of titanium mesh cage after anterior cervical corpectomy and fusion
Authors: Wang Zhiqiang , Mei Jun , Feng Xiaoning , Deng Chen , Tian Xuefeng , Lv M. S. Junqiao , Sun Lin
Published: June 2022

Study Design: This study was a retrospective review.Objective: To study the predictive effect of Hounsfield units (HU) value in cervical vertebral body derived from computed tomography (CT) on the early titanium mesh cage (TMC) subsidence after anterior cervical corpectomy and fusion (ACCF).Methods: This retrospective study was conducted on patients who underwent ACCF at one institution between January 2014 and December 2018. For age, gender, body mass index (BMI), disease type, surgical segment, whether merge ACDF, HU value of the vertebral body and endplate, vertebral body height loss, cervical lordosis angle and cervical sagittal alignment were recorded. VAS, JOA and NDI were used to assess clinical efficacy. Univariate analysis was performed to screen the influencing factors of TMC subsidence, and then logistic regression was used to find out the independent risk factors. The ROC curve and area under curve (AUC) were used to analyze the HU value to predict the TMC subsidence.Results: A total of 85 patients accepted ACCF were included in this study, and early titanium mesh cage subsidence was demonstrated in 29 patients. The subsidence rate was 34.1%. The JOA, VAS and NDI scores significantly improved in both groups after operation. Between the subsidence and non-subsidence groups, there were significant differences in age, intervertebral distraction height, HU value in both upper and lower vertebral body and endplate. The logistic regression analysis proved that the HU value of lower vertebral body was an independent risk for TMC subsidence, the AUC was 0.866, and the most appropriate threshold of the HU value was 275 (sensitivity: 87.5%, specificity: 79.3%).. Conclusion: Preoperative cervical CT value is an independent correlative factor for early TMC subsidence after ACCF, and patients with low CT value of the inferior vertebral body of the operative segment have a higher risk of TMC subsidence in the early postoperative period.Trial registration: This study is undergoing retrospective registration.
8-HOQ a natural chelating agent from Streptomyces spp inhibits A549 lung cancer cell lines via BCL2/STAT3 regulating pathways
Authors: Balthazar Joseph Devadass , Packiam Soosaimanickam Maria , Emmanuel C. , Thirugnansambantham Krishnaraj , Sheikh Abdullah , Alghafis Saleh Fahad , ibrahim Hairul-Islam
Published: June 2022

Biomolecules from Streptomyces spp. are emerging sources of natural drugs and have been focused on over the decade. The discovery of bioactive chemotherapeutic molecules from soil Streptomyces spp. has opened the medium for the search for natural drugs. In the current study, 8-HOQ was extracted and purified from soil Streptomyces spp and was evaluated on A549 and BEAS cell lines. The apoptotic and caspase mediated pathways were evaluated using cell proliferation, dual fluorescent staining, migration, invasion and mRNA as well as protein quantification of apoptotic markers. In vitro cytotoxicity test revealed that 8-HOQ possesses potent anticancer activities with IC50 values of 26 µM, 5 µM, 7.2 µM at 24 h, 48 h, and 72 h respectively against A549 lung cancer cell lines. The result also demonstrated that 8-HOQ from Streptomyces spp significantly inhibited the A549 lung cancer cell lines and activated the intrinsic pathways of apoptosis. The caspase-3 and 8 activities were potentially elevated in 8-HOQ treated A549 cell lines and confirmed that 8-HOQ mediated A549 cancer cell death through the intrinsic pathway. The results explored caspase-mediated apoptosis as a mechanism underlying the inhibition of cancer cell viability in a dose-dependent manner. The expression of P53, BCL2 and STAT3 were inhibited in A549 cell lines and confirmed the metastasis inhibitory potential of 8-HOQ by blocking migration and invasion in A549 cell lines. These results indicated that 8-HOQ from Streptomyces spp. potentially inhibited growth and migration of A549 lung cancer cell lines.
Aplicação de indicadores de sustentabilidade na gestão de resíduos sólidos em Tangará da Serra, Mato Grosso, Brasil
Authors: Carvalho Daniela da Silva , Sguarezi Sandro Benedito , Froehlich Anderson Gheller
Published: June 2022

Dentre os impactos ambientais da atualidade, a geração de resíduos sólidos é a que mais tem causado preocupação, uma vez que praticamente todas as atividades econômicas geram algum tipo de resíduo em suas atividades. Para eliminar ou reduzir tais impactos, torna-se premente a adoção de uma Gestão dos Resíduos Sólidos (GRS) eficiente, que garanta o máximo de reaproveitamento e reciclagem, bem como reduza a produção dos rejeitos. O uso de indicadores de sustentabilidade pode contribuir significativamente para tal propósito. Esta pesquisa teve como objetivo aplicar indicadores para verificar o nível de sustentabilidade e o desempenho da GRS no Município de Tangará da Serra, Estado do Mato Grosso, Brasil. A metodologia de análise deu-se a partir das respostas para uma matriz de indicadores, conforme interesse da pesquisa. A aplicação desses indicadores permitiu identificar as demandas na GRS no município e definir ações prioritárias, auxiliando na tomada de decisão e fornecendo subsídios para o aprimoramento da política pública local. A dimensão que se apresentou mais favorável à sustentabilidade foi a social, com índice de 84% da nota máxima. E a dimensão que se apresentou menos favorável à sustentabilidade foi a ambiental, com 74% da nota máxima.
Modelagem de potencial energético de painel fotovoltaico a partir de dados de base de sensoriamento remoto por satélite
Authors: Nascimento Marcos Guedes do , Menezes Júnior Raimundo Aprígio de , Souza Bruno César Bezerra Nóbrega de , Mello Sérgio Costa de
Published: June 2022

O aumento da população mundial nos últimos séculos e o estabelecimento da sociedade de consumo fizeram a demanda por recursos naturais atingir níveis acima da capacidade de regeneração da natureza. Além disso, o emprego de fontes não renováveis de energia, sobretudo, os combustíveis fósseis, causaram problemas ambientais sem precedentes, a exemplo da poluição do solo, das águas e do ar, tendo esta última com uma de suas consequências, a aceleração do efeito estufa. Deste modo, a procura por soluções às questões ambientais e por garantia de meios de sobrevivência às próximas gerações se tornaram objetivos centrais da ciência na contemporaneidade. Dentre as áreas de estudo, destaca-se aquela voltada ao desenvolvimento de tecnologias que propiciem a acessibilidade a fontes renováveis à sociedade. Seguindo esta linha de ação, a presente pesquisa tem por objetivo modelar matematicamente um painel solar, composto por células fotovoltaicas padrão, a ser implementado no edifício sede do Programa de Pós-Graduação em Desenvolvimento e Meio Ambiente da Universidade Federal da Paraíba. Na circunstância admitida por conjectura, o painel fotovoltaico capta a energia proveniente da radiação solar incidente na localidade considerada, durante os anos de 2015 a 2020, sendo as informações sobre a irradiância média obtidas na base de dados de sensoriamento remoto por satélite TERRACLIMATE. A análise sobre os resultados alcançados revela que, ordinariamente, os valores de corrente elétrica ficaram contidos no intervalo que vai de 2,5 A a 5,0 A e, a potência, por sua vez, variou entre 120 W e 210 W. Para um ano qualquer, a irradiância solar sobre o local se manteve entre 75 W/m2 e 150 W/m2. A corrente média, no que lhe concerne, apresentou variação entre 3 A e 5 A, enquanto que a potência média oscilou de 140 W a 200 W. Gerar energia elétrica a partir de células fotovoltaicas, apesar de só ser possível no período diurno, para o local onde se propõe instalar o painel fotovoltaico, ficou evidenciado que caso seja devidamente armazenada em baterias, a quantidade gerada é suficiente para suprir demandas de baixo e médio consumo de energia, uma vez que o saldo de produção mensal está acima de 140 W.
A atuação do veículo híbrido no mercado brasileiro: análise das oportunidades de inserção no mercado automotivo
Authors: Oliveira Sérgio Levi Souza de , Loureiro João Carlos de Freitas , Pessôa Luiggi Cavalcanti
Published: June 2022

Devido às regulamentações ambientais mais rigorosas em consonância com o acordo de Paris e os objetivos de sustentabilidade da ONU, a eletrificação da propulsão dos automóveis é inevitável, sobretudo no Brasil. A implementação dessa tecnologia no mercado automotivo brasileiro é minuciosa, pois além de competitiva despende de altos investimentos das fabricantes e sujeita à aceitação do usuário. À vista disso e considerando a pouca disponibilidade de trabalhos que versam sobre essa composição de questões, o presente artigo foca em organizar e analisar informações técnicas e de mercado dos automóveis comercializados no Brasil. O objetivo foi identificar oportunidades de inserção da tecnologia híbrida como diferencial competitivo. Para isso foram utilizados métodos de Data Science como correlação, clusterização e visualização de dados em conjunto com as ferramentas Excel e Jupyter Notebook em linguagem Python. Os resultados apontaram quatro segmentos de veículos promissores, sendo o de maior oportunidade o de sedan de Entrada Compacto devido à faixa de mercado e ineditismo da tecnologia híbrida.
Aplicações da lama de ETA visando à mitigação de impactos ambientais: uma revisão integrativa
Authors: Santos Luana Kelly de Jesus , Pinto Caio de Oliveira , Cavalcanti Luiz Antônio Pimentel
Published: June 2022

O incremento no consumo de água tratada devido ao crescimento populacional, bem como o consequentemente incremento da produção industrial faz que seja gerado um enorme volume de lodo resultante do processo de tratamento da água bruta que necessita ser descartado. Este resíduo por diversas vezes é descartado diretamente na natureza, não respeitando a devida legislação e pondo em risco o meio ambiente. Nesse aspecto, o presente estudo apresenta uma revisão integrativa da literatura visando a sugerir possíveis destinos alternativos para o lodo de ETA, para assim mitigar os possíveis impactos ambientais que o material causa quando descartado de maneira indevida. A revisão foi realizada selecionando trabalhos com recorte temporal de 2007 a 2021 que abordassem o lodo de ETA nas seguintes frentes: aplicada accimento, argamassa e cerâmica, utilizado como adsorvente, seu comportamento quando inserido na codigestão e decantação assistida em ETAR, adotada para insumo na agricultura e na recuperação de áreas degradadas e, por fim, aplicada em barreiras impermeabilizantes. Desses trabalhos, foi possível observar que o lodo de ETA é extremamente versátil, demonstrando-se viável na aplicação frente aos campos supracitados, e dando uma nova perspectiva de utilização a um material que é rejeito de um processo amplamente aplicado.
As fronteiras entre homem-gado-floresta
Authors: Sessin-Dilascio Karla , Sousa Tatiane Silva , Rossi Charles Borges
Published: June 2022

O aumento da prática da pecuária em reservas extrativistas na Amazônia levanta preocupação quanto ao futuro destas áreas no cumprimento da função de proteger os meios de vida de comunidades extrativistas e de garantir a utilização e a sustentabilidade dos recursos naturais. Até que ponto a pecuária como prática pode influenciar a mudança do uso e ocupação destas áreas protegidas? Este artigo trata da relação multiespécie entre homem-gado em uma comunidade ribeirinha do Vale do Juruá. O artigo mobilizará dados empíricos sobre os hábitos alimentares, a criação do gado e a percepção sobre a floresta da Comunidade Periquito da Reserva Extrativista Riozinho da Liberdade. Ao pensar "junto" e "com" o artigo tenta compreender as fronteiras possíveis entre a tríade homem-gado-floresta.
Analytical and Experimental Study on Flexural Behavior of Beam-column Joint with Addition of Polypropylene Fibers
Authors: Dhanabal P , Reddy P Narendra , Sushmitha K S
Published: June 2022

Key scope of this research is evaluation of actions of beam to column joints under the impact load acting on it. The beam-column joints, a common area between frame beams and columns. It is the most critical zone to ensure the global response of such momentary resistance structures. Several approaches have been attempted over the years by many civil engineers and practitioners to improve the deficiently thorough joint in between beam and column. The highest bending moment and shear forces in the framed structures are at the junction area. As a result, that joint between beam and column is one of a collapse zone. Joint in outer is more important among the beam-column joints. The effect may be caused by a weight falling on the design object or possibly falling off the design object and hitting the hard surface. In this work, an emphasis has been made to understand the joint vulnerability against impact loads and its behavior is analyzed using the ANSYS software. From this experimental program observed that, impact resistance in RCC beam to column joints can be improved by improving stiffness by added polypropylene fibers and energy absorption can also be improved.
Predicting Marital Satisfaction through Self-Esteem and Sexual Satisfaction in a Ghanaian Orthodox Church
Authors: Abomah Peter Worlanyo
Published: June 2022

The study aimed at predicting marital satisfaction through self-esteem and Sexual satisfaction in a Ghanaian orthodox church. The objectives were to determine the correlation between sexual satisfaction and marital satisfaction, to ascertain the correlation between self-esteem and marital satisfaction, and to ascertain the gender difference in marital satisfaction. The descriptive survey research design was adopted. The target group was married couples. Simple random sampling was used to select one hundred and sixty married persons with tenure of marriage between two years and fifty years. Questionnaires on Larson’s sexual satisfaction and Rosenberg’s self-esteem was used for data collection. The cronbach reliability coefficient for the instrument was 0.68 and 0.72, respectively. Results indicate that there was a negative correlation between sexual satisfaction and marital satisfaction. There was a positive correlation between self-esteem and marital satisfaction. There was no statistically significant difference in gender and marital satisfaction. Based on the discussion of literature review, recommendations were made.
The Influence of Social Media Social Support on the Flourishing Homosexual Identity: A Case Study of the Lesbian Gay Bisexual Transgender Queer (LGBTQ) Community in Accra-Ghana
Authors: Abomah Peter Worlanyo
Published: June 2022

The aim of the study was to explore the influence of social media and social support on the flourishing homosexual identity in Accra, Ghana. The objectives were to determine the extent to which social support influence’s homosexual identity, the correlation between homosexual identity and flourishing levels among homosexuals, to ascertain the extent to which media, emotional, and social support predicts how homosexuals flourish, and finally to as certain how differences in the level of education predict how homosexuals flourish in Accra, Ghana. A case study design was employed. The population for this study was associates of the homosexual Community in Accra-Ghana. Using a purposive sampling technique, 142 homosexual respondents answered a standard questionnaire. Berlin Social Support scale (BSSS), Diener Flourishing scale Lesbian, Gay, and Bisexual Identity Scale were used on demographics, social support, flourishing, and lesbian, gay, bisexual identity. Data was analysed using simple linear regression, Pearson product-moment correlation coefficient, and one-way analysis of variance. Results obtained indicated that social support does not predict homosexual identity among homosexuals in Accra. As an individual homosexual identity increases so does the level with which the individual flourishes. Thirdly, social media emotional, and social support was found to be a predictor of flourishing among homosexuals in Accra. Finally, the results also indicated that differences in the level of education do not predict how homosexuals flourish in Accra. The conclusion indicates that study has shown that differences in the level of education among homosexuals do not influence the extent to which homosexuals flourish.
Availability, Utilization, and Support Systems of Ehealth Resources in Nursing Practice among Nurses in Cape Coast, Ghana
Authors: Nukunu Frank
Published: June 2022

Information and communication technology (ICT) is transforming healthcare delivery at a fast rate. Nurses who form most of the health workforce are strategically positioned to champion the transition to digital health care. Ghana is fast adopting eHealth. However, there is little evidence on how well nurses are using these technologies. A descriptive cross-sectional study using a quantitative approach was conducted to examine the availability, utilization, and support systems of eHealth resources in the nursing profession. A multi-stage sampling technique was employed. Data collated from 206 registered nurses in Cape Coast revealed that respondents were predominantly female (61.7%), and 38.3% were males. The result suggests that good resources for eHealth service delivery were available with association wards and resources availability (χ2=19.691, P= .012). Comparatively, the A&E ward had the most resources compared to the medical ward (p=.018), OPD (p=.012), Surgical ward (p=.013), Theatre (p=.003), Children ward (p=.000), Obs/Gynae ward (p=.002), ICU (p=.042) and NICU (p=.011). Also, most nurses have received adequate training, technical support, and internet connectivity towards eHealth resources usage. The study further revealed that most facilities did not have access to eLibraries. Monitoring and evaluation were either erratic or non-existent. Though the study results showed some promise in the digitization of healthcare in Ghana, there is more to be done to bridge the gap between the health needs of the population and the technologies required to meet them.
New Insights into Cold Shock Proteins Effects in Human Cancer: Correlation
with Susceptibility, Prognosis and Therapeutical Perspectives
Authors: Mirabile Giuseppe , Campo Chiara , Ettari Roberta , Aguennouz M'Hammed , Musolino Caterina , Allegra Alessandro
Published: June 2022

The microenvironment of the tumor cells is central to its phenotypic modification.
One of the essential elements of this milieu is thermal regulation. An augment in local
temperature has been reported to augment the tumor cell's responsiveness to chemoand
radiation treatment. Cold shock proteins are RNA/DNA binding proteins identified
by the existence of one or more cold shock domains. In humans, the best studied components
of this group of proteins are called Y-box binding proteins, such as Y-box binding
protein-1 (YB-1), but several other proteins have been recognized. Biological functions
of these proteins extend from the control of transcription, translation and splicing to the
regulation of exosomal RNA content. Several findings correlate an altered cold shock
protein expression profile with tumor diseases. In this review we summarize the data for
a causative participation of cold shock proteins in cancer onset and diffusion. Furthermore,
the possible use of cold shock proteins for diagnostics, prognosis, and as targets
for cancer treatment is exposed.
Chemotherapeutic Activities of Dietary Phytoestrogens against Prostate Cancer:
From Observational to Clinical Studies
Authors: Sohel Md. , Sultana Habiba , Sultana Tayeba , Mamun Abdullah Al , Amin Mohammad Nurul , Hossain Md. Arju , Ali Md. Chayan , Aktar Suraiya , Sultana Armin , Rahim Zahed Bin , Mitra Sarmistha , Dash Raju
Published: June 2022

Prostate cancer remains one of the most frequent and deadliest malignancies in males, where the rate of disease progression is closely associated with the type of dietary intake, specifically Western-style diet. Indeed intake of the Asian diet, which contains abundant phytoestrogens, is inversely correlated with a higher risk of prostate cancer, suggesting a chemoprotective effect of phytoestrogen against cancer progression. Although the role of phytoestrogens in cancer treatment was well documented, their impact on prostate cancer is not well understood. Therefore, the present review discusses the possible chemopreventive effect of phytoestrogens, emphasizing their efficacy at the different stages of carcinogenesis. Furthermore, phytoestrogens provide a cytoprotective effect in conventional chemotherapy and enhance chemosensitivity to tumor cells, which have also been discussed. This compilation provides a solid basis for future research on phytoestrogens as a promising avenue for anticancer drug development and also recommends these beneficiary compounds in the daily diet to manage and prevent prostate cancer.
Therapeutic Management of Lymphoma: Conventional Strategies and
Overcoming Treatment Barriers with Nanotherapeutics
Authors: Le Tien V. , Kim Erica , Togba-Bass Tracy , Bom Joyce C. , Campbell Robert B.
Published: June 2022

According to the American Cancer Society, the prevalence of lymphoma remains high in
the United States with an estimated 90,390 new cases, and 21,680 deaths annually. Although current
chemotherapeutic regimens approved by the FDA can effectively improve treatment outcomes,
the prognosis remains poor with numerous complications. Current therapeutic strategies have faced
multiple challenges limiting desired therapeutic effects. With the multitude of clinical barriers faced
by conventional treatment strategies, researchers continue to explore the use of nanotherapeutics
over more conventional treatment options. The engineered nanoparticles include starting materials
from a number of biocompatible sources, and the final products can safely incorporate therapeutic
agents, improve drug selectivity to tumor targets, and enhance efficacy profiles, all while reducing
toxicity associated with the drug payload. These are tremendous potential advantages. This review
summarizes the molecular basis of lymphoma, disease progression, and therapeutic challenges encountered
during treatment. The discussions further highlight preclinical and clinical results at the
different clinical stages, reviewing the different types of lymphoma, and summarizing how nanotherapeutics
have addressed challenges confronting treatment.
Oligonucleotide-conjugated Nanomaterials as Biosensing Platforms to
Potential Bioterrorism Tools
Authors: Frias Isaac A.M. , da Silva Junior Alberto G. , Oliveira Maria D.L. , Andrade César A.S.
Published: June 2022

Availing diseases as warfare began before humans learned that microorganisms are involved in
the dissemination of infections. In the past, war brigades had the intention to weaken rival groups by using
festering corpses with the premeditated purpose of causing disease. Nowadays, the unfortunate improvement
of biowarfare is indubitably linked to our extensive collaborative work in exploring the use of
microorganisms and their derivatives to create products and services that are beneficial to society. Natural
defense barriers such as innate immunity and the immune specific adaptive response come to mind when
thinking of bacteria and virus potentially being operated as tools for biological warfare. On the other
hand, some bacterial toxins disrupt the immune cell functions and others do not trigger sufficient immune
response, thus being not suitable for immunotherapy applications. As an alternative to these drawbacks,
the systematic evolution of ligands by exponential enrichment (SELEX) develops specific nucleic acid or
peptides for a variety of targets, including toxins. These aptamers are efficiently produced in vitro using
enzymes or synthetical synthesis within days, low cost, and reproducibility. Oligonucleotide aptamers are
a nanotechnological high spot because of their physicochemical characteristics such as resilience, pH
responsiveness, and addressability at the nanoscale. Additionally, they induce no immunogenicity and can
be modified by association with nanoparticles to increase their stability in biological environments. In this
review, we explore the recent trends and perspectives on biosensor construction based on oligonucleotide
aptamer-conjugated nanomaterials as effective biosecurity devices and their relevance to the development
of risk-assessment protocols that could be used as intelligent barriers to provide continuous, cheap, and
easy monitoring to prevent unexpected attacks.
Chlorpheniramine, an Old Drug with New Potential Clinical Applications:
A Comprehensive Review of the Literature
Authors: Rizvi Syed A.A. , Ferrer Gustavo , Khawaja Uzzam A. , Sanchez-Gonzalez Marcos A.
Published: June 2022

Chlorpheniramine Maleate (CPM), also known as chlorphenamine, is a potent alkylamine
first-generation H1 antihistamine that has been used since the 1950s. CPM is a widely popular drug
commonly used to treat allergic conditions, given its antihistamine properties. Although mainly used
in over-the-counter treatment for cough and colds, various studies discuss a wide range of CPM's clinical
uses, such as treating asthma, plasma cell gingivitis, chronic urticaria, and depression, among others.
This antihistamine is usually taken orally; however, intravenous, intramuscular, and subcutaneous
routes have been documented. Intranasal routes of this drug have recently been explored, especially
due to its antiviral properties against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Accordingly, given CPM's extensive medical and safety profile, the present review explores this versatile
drug's current and potential clinical applications. Although it is widely used mainly for treating
common colds and aforementioned allergic conditions, CPM can be used for other clinical indications.
The repurposing of CPM for other clinical indications, such as COVID-19, needs to be further explored
through more extensive studies.
The Russian Labor Market in the Information Technology Industry in 2021
Authors: Tomakova R. A. , Tomakov V. I.
Published: June 2022

Relevance. The pandemic served as a catalyst for the digitalization of the economy, accelerated the processes of automation and digitalization in all spheres of the economy and in the social life of society. The key problem faced by IT companies in connection with the widespread introduction of information technology is the increased need for qualified programmers and analysts. The current situation has led to the need to assess the labor market of the IT sector in order to identify trends in meeting the demand for IT specialists.

The purpose of the study: to assess the current situation and trends in the development of the labor market of IT specialists in our country after a one-year pandemic.

The objectives: the number of IT specialists in the country's economy; the job market, requests and offers from employers; the structure of vacancies; activity and portrait of applicants.

The research methodology is based on a systematic approach. The research is based on a resource approach. Traditional methods for theoretical and applied research were used - statistical analysis, synthesis, comparison, generalization. The research material was statistical data of Rosstat and the All-Russian federal database of vacancies and resumes, analytical materials of labor market research of IT specialists.

Results. The pandemic accelerated the processes of digitalization of the economy and social life of society, caused a new round of competition for IT specialists. Research has revealed a growing need for IT specialists in all areas of the economy. There was an imbalance of supply and demand in the industrial labor market. Programmers are one of the most needed and paid specialists, the need for which is observed in all sectors of the economy.

Conclusions. There was a need to change the paradigm of staff search and recruitment. How well the employer company will be represented on the market and how well it will behave with applicants in the process of coordinating the interests of the employer and the employee, so the success of hiring the right specialist will be ensured.
Academic Procrastination Among Students: a Sociological Analysis
Authors: Vetrova O. A. , Oboznaya M. V.
Published: June 2022

Relevance. The student's age plays a key role in the process of educational and professional socialization of the individual, during which the stage of growing up, developing a sense of identity and planning their future takes place. One of these stages is the process of educational activity, which plays an important role in strengthening faith in one's own success, the ability to be productive. However, there are also obstacles that limit the complex formation of personality ‒ procrastination in postponing academic affairs or academic procrastination.

The purpose is to determine the nature of the formation of academic procrastination of students, as well as to identify the importance of motivation in the structure of these factors.

Objectives: to conduct an empirical study and analyze the reasons for the formation of academic procrastination of students; to study the educational motives of students, to determine the fundamental difference between the performance of long-term and daily educational tasks, cases of willing fulfillment of these tasks, as well as the emotional prerequisites of students who have decided not to perform educational tasks, regardless of their urgency and time costs.

Methodology. The study used a methodology aimed at identifying the motives of educational activity among students, the methodology "PASS procrastination assessment Scale" in the adaptation of M. V. Zvereva, and factor analysis by the method of principal components, as well as a survey of student youth by means of a questionnaire.

Results. Interpretation of the data obtained allowed us to confirm the existence of the problem of academic procrastination and its impact on academic motivation among students. Professional and educational-cognitive motives are among the driving motives that guide students to academic activity. The most common form of academic procrastination is procrastination in completing long-term tasks.

Conclusions. Further sociological research should take into account a whole set of theoretical and methodological grounds on the basis of which it is possible to present the phenomenon of academic procrastination in its entirety and totality.
The Crisis of the Sovereign State-Nation and the "Rational Discussion": the Liberal Discourse of the "Salvation" of Democracy and the "Common Good"
Authors: Maltsev K. G. , Maltseva A. V.
Published: June 2022

Relevance. The crisis of the modern European sovereign nation-state is defined as existential (not "technical"); therefore, we should talk about a socio-philosophical study of the "crisis of the foundations".

The purpose of the article is to present the non-reality of the foundations of the nation-state in modern times, totally determined by the dominant liberal economic paradigm of the political (J. Agamben), and modern ways of removing the consequences of the political crisis in the liberal tradition.

The objective is based on the interpretation of these statements - to determine the conditions and boundaries of the possibility of "response" from the perspective of "liberal metaphysics".

Methodology. According to K. Schmitt, liberalism is "consistent metaphysics", the essence of which is defined as "endless free / public discussion"; a consistent liberal "response" to the challenge, therefore, can only be given on the basis of the named "essence" ‒ the main methodological position that determines the structure and content of this article.

Results. It was revealed, that a nation as a form of political unity of a sovereign people, in the perspective of liberal metaphysics, cannot be relied on as a "substance of the state". That the people-sovereign is "split in itself" and the available ways of actualizing its real unity are no longer "valid". That the mechanisms of political representation that democratically legitimize the power institutions of a sovereign nation-state in its new European, that is, liberal, form, need radical reform. "Free discussion", stated in the article, is limited in the possibility of "answering" the "existential crisis"; this presupposes the need to reduce the "political" (Schmitt's "concept of the political" as an "existential solution" of the sovereign in the horizon of the existential opposition "friend – enemy") and "reduction" by means of such a reduction of the "essentially political" to technical issues of "governance" (M. Weber). Three main methods of "liberal reduction of the political" are distinguished: "logical-epistemological" by Y. Elster, "ethical" by J. Rawls, "aesthetic" by R. Ankersmit, and their characteristic "features" are determined.

Conclusion. It is concluded that a consistent liberal political philosophy, losing in its understanding of politics as government, the distinction between auctoritas and potestas, is unable to thematize the "existential", that is, political, crisis of the foundations of a sovereign nation-state.
Ecological Technosphere as the Basic Context of the Formation of the Sociotechnical Landscape
Authors: Belkina V. A.
Published: June 2022

Relevance. The rapid development of the technosphere has played a huge role in the qualitative change of numerous processes in all spheres of human social life. The evolution of the modern anthropo-techno sphere, including the formation of the latest technologies, has led to the emergence of the sociotechnical landscape (STL). STL, being a system of representation of various phenomena of the ecological technosphere, at the same time causes various problems and provides significant opportunities for humanity. All this makes it necessary to determine the prospects for the greening of the technosphere, as well as the main trends in the influence of STL models on modern society, man and the environment. The purpose is conducting a philosophical analysis of the ecological technosphere as the basic context of the formation of the sociotechnical landscape (STL).

Objectives: to define the essence of the concept of "ecological technosphere" in its relationship with the new socio-cultural model of the lifestyle of human civilization; consider the TABLE construct as an explication of the ecological technosphere and the anthropoecological system as a whole; to trace the formation of STL through the prism of industrial revolutions; describe Industry 4.0 as a result of the integration and combination of the effects of multiple technologies; to identify the main prospects for further interaction between the technosphere and the ecosphere.

Methodology. To substantiate the concept of anthropological complementarity, assuming the fact that human activity includes simultaneous subordination to nature and control over it, an analysis of the processes and mechanisms that underlie the formation of STL as an explication of the ecological technosphere was carried out.

Results. The presented manuscript presents the results of the philosophical analysis of the STEEL construct as an explication of the ecological technosphere and the anthropoecological system as a whole. In the course of this study, the formation of STL was considered through the prism of industrial revolutions, and the main prospects for further interaction between the technosphere and the ecosphere were identified.

Conclusions. Conducting an interdisciplinary analysis of the role of the technosphere as a determining factor in the development and formation of all other technical systems and products is an urgent and significant problem. A comprehensive study of the ecological technosphere as the basic context of the formation of STL is necessary, due to the fact that it created the prerequisites for the emergence of artificial intelligence and convergent technologies, which currently determine global economic, cultural, social and industrial trends.
Plasmapheresis for Thrombotic Microangiopathy Due to a Post-transplant Lymphoproliferative Disorder
Authors:   Department of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53792, USA, Yu Qiqi , Suknuntha Kran ,   Department of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53792, USA,   Chakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Samut Prakan, Thailand, 10540, Zhong Weixiong ,   Department of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53792, USA, Matson Daniel R. ,   Department of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53792, USA, Hess Aaron S. ,   Department of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53792, USA, Rose William N. ,   Department of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53792, USA
Published: June 2022

We report a case of thrombotic microangiopathy (TMA) diagnosed in the kidney allograft of a 59-year-old woman who had developed plasmacytoma type monomorphic posttransplant lymphoproliferative disorder (PTLD) 30 years after a simultaneous pancreas and kidney transplant. This report demonstrates a rare etiology of TMA in a kidney allograft occurring in association with PTLD-associated monoclonal gammopathy. The main teaching points are: 1) PTLD may be considered in the work-up of a new TMA in the immunosuppressed post-transplant setting, and 2) a paraprotein-associated condition should be considered as clinically relevant coexistent in a patient with TMA because paraproteins are over-represented in patients with otherwise unexplained TMAs.
Identifying Personality Characteristics and Indicators of Psychological Well-Being Associated With Attrition in the Motivation Makes the Move! Physical Activity Intervention: Randomized Technology-Supported Trial
Authors: Kaseva Kaisa , Tervaniemi Mari , Heikura Enni , Kostilainen Kaisamari , Pöyhönen-Alho Maritta , Shoemaker J Kevin , Petrella Robert J , Peltonen Juha E
Published: June 2022

Background

Data attrition has been a common problem in longitudinal lifestyle interventions. The contributors to attrition in technology-supported physical activity interventions have not been thoroughly studied.

Objective

The present study examined the roles of personality characteristics and indicators of psychological well-being in data attrition within a technology-supported, longitudinal intervention study with overweight adults.

Methods

Participants (N=89) were adults from the Motivation Makes the Move! intervention study. Data attrition was studied after a 3-month follow-up. Participants’ personality characteristics were studied using the Short Five self-report questionnaire. Psychological well-being indicators were assessed with the RAND 36-item health survey, Positive and Negative Affect Schedule, and Beck Depression Inventory. Logistic regression analyses were conducted to assess the risk of discontinuing the study. The analyses were adjusted for sex, age, study group, and educational status.

Results

At the 3-month follow-up, 65 of 89 participants (73% of the initial sample) had continued in the study. Participants’ personality characteristics and indicators of psychological well-being were not associated with the risk of dropping out of the study (all P values >.05). The results remained the same after covariate controls.

Conclusions

Participant attrition was not attributable to personality characteristics or psychological well-being in the Motivation Makes the Move! study conducted with overweight adults. As attrition remains a challenge within longitudinal, technology-supported lifestyle interventions, attention should be paid to the potentially dynamic natures of personality and psychological well-being, as well as other elements beyond these.

Trial Registration

ClinicalTrials.gov NCT02686502; https://clinicaltrials.gov/ct2/show/NCT02686502
Mobile health apps for supporting brace treatment of patients with idiopathic scoliosis: a scoping review (Preprint)
Authors: Jang Chan Woong , Park Jung Hyun , Yoo Myungeun , Bang Myeonghwan , Cho Han Eol
Published: June 2022

BACKGROUND

Idiopathic scoliosis is one of the most common musculoskeletal disorders related to the spine. Brace treatment has emerged as a proven method to treat scoliosis; however, compliance of patients has been reported to be poor. Mobile health (mHealth), such as smartphone applications, can help support brace treatment for idiopathic scoliosis.

OBJECTIVE

This study reviewed published literature on mHealth apps to support the brace treatment of scoliosis patients and documented currently available commercial mHealth apps that help the patient’s bracing.

METHODS

Following the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) guidelines, we searched commercial mHealth apps in Google Play and the App Store, and used five electronic databases for a comprehensive published literature search conducted in February 2022.

RESULTS

Four published studies and eight commercial mHealth apps were included in the final analysis. Consequently, four categories (data acquisition, compliance enhancement, educational components, additional functionalities) and twelve subcategories of functionalities (scoliosis severity check, brace wearing time import, brace connection with sensors, goal setting, data visualization, motivation, testimonial and practical tips, general information of scoliosis, PSSE, brace wearing time export, direct communication, appointment reminder) were evaluated. This review revealed that the quality of these apps was not high by transparency, health content, excellent technical content, security/privacy, issues of usability, and subjective ratings (THESIS) guidelines.

CONCLUSIONS

It is necessary to develop appropriate and diverse functionalities through high quality apps for supporting brace treatment of patients with idiopathic scoliosis.
Associations between OCD severity and vocal features in children and adolescents: A statistical and machine learning analysis plan (Preprint)
Authors: Clemmensen Line K. H. , Lønfeldt Nicole , Das Sneha , Lund Nicklas Leander , Uhre Valdemar , Mora-Jensen A.R. Cecilie , Pretzman Linea , Uhre Camilla Funch , Ritter Melanie , Korsbjerg Nicoline Løcke Jepsen , Hagstrøm Julie , Thoustrup Christine Lykke , Clemmensen Iben , Plessen Kersten Jessica , Pagsberg Anne
Published: June 2022

UNSTRUCTURED

Artificial intelligence (AI) tools have the potential to objectively identify youth in need of mental health care. Speech signals have demonstrated promise as a source for predicting various psychiatric conditions and transdiagnostic symptoms. Thus, we designed a study testing the association between obsessive compulsive disorder (OCD) diagnosis and symptom severity on vocal features in children and adolescents. Here, we present an analysis plan and statistical report for the study. Audio recordings of clinical interviews of 15 children and adolescents with OCD and 15 children and adolescents without a psychiatric diagnosis will be analyzed. Youth were between 8 and 17 years old. We will test the effect of OCD diagnosis on computationally-derived scores of vocal activation and valence using an analysis of variance. To test the effect of OCD severity classifications on the same computationally-derived vocal scores, we will use logistic regression. Finally, we attempt to create an improved indicator of OCD severity by refining the model with more relevant labels. Models will be adjusted for age and gender. Model validation strategies are outlined. A major strength is that we include age and gender in our models to increase classification accuracy. A major challenge is the suboptimal quality of the audio recordings, which are representative of in-the-wild data and a large body of recordings collected during other clinical trials. This pre-registered analysis plan and statistical report will increase validity of the interpretations of the coming results.