bluuebunny/crossref_metadata_2025 huggingface dataset:
ctDNA as a prognostic biomarker in resectable CLM: Systematic review and meta-analysis
Authors: Wang Da , Zhao Penglai , Lu Tingting , Ren Jingyao , Zhu Lihui , Han Xiaoyong , Zhang Guangming , Dong Xiaohua , Ma Haizhong , Yu Miao , Cai Hui
Published: May 2023

Cell-free circulating tumor DNA (ctDNA) is synthesized by tumor cells, including metastatic tumors, and circulates in the bloodstream. Evidence suggests that ctDNA is a potential predictive and prognostic biomarker for colorectal cancer (CRC), but its predictive efficacy in detecting CRC liver metastasis (CLM) remains unclear. Additionally, its utility in the clinical setting needs further investigation. We conducted a meta-analysis to determine the utility of ctDNA as a biomarker for predicting the prognosis of CLM and investigate the relationship between CLM and ctDNA positivity. A literature search was performed in electronic databases to identify relevant studies published up to March 19, 2022. We retrieved data on overall survival (OS), disease-free survival (DFS), and recurrence-free survival (RFS) for both ctDNA-positive and ctDNA-negative colorectal liver metastasis (CLM) patients from the selected articles. Hazard ratios (HRs) were also calculated for these survival outcomes analysis was also performed. The stability of the combined meta-analysis was verified by sensitivity analysis and publication bias evaluation. Ten trials were included, and 615 patients were evaluated. In patients with CLM, pooled HRs revealed a substantial link between ctDNA positivity and RFS/DFS. Subgroup analysis revealed that ctDNA had a prospective detection value. Sensitivity analysis and publication bias evaluation indicated stable results. Although the results on pooled HR for OS suggested that ctDNA-positive patients had a shorter survival time, their pooled HRs had a relatively evident heterogeneity, and sensitivity analysis and publication bias evaluation indicated that pooled HRs were extremely unstable. In conclusion, our results demonstrate that ctDNA appears to be a prognostic biomarker for resectable CLM patients.
Семантические горизонты понятия «смех» в русской культуре
Authors: Прозоров Валерий Владимирович
Published: May 2023

Семантические горизонты понятия «смех» в русской культуре ценностно ориентированы. С большой долей уверенности обозначаются пределы смеха желательного / нежелательного, приемлемого / неприемлемого, уместного / неуместного. Смех избирательно любит своих, близких, связанных взаимной симпатией, сходством вкусов, привычек, взглядов на жизнь. Сохраняют силу испытанные смеховые предпочтения, запечатленные в русской словесности. На заметной периферии обнаруживает себя смех высокомерный, оскорбительный и злорадный. Не в чести самодовольная усмешка и язвительная ухмылка. Всегда дорого ценится смех духоподъемный, искренний и проникновенно добрый, исподволь отзывающийся светлой грустью. Для более четкого выявления примет национальной специфики смеха необходима реализация разносторонних кросс-культурных исследований.
Bott-Chern hypercohomology and bimeromorphic invariants
Authors: Yang Song , Yang Xiangdong
Published: May 2023

The aim of this article is to study the geometry of Bott-Chern hypercohomology from the bimeromorphic point of view. We construct some new bimeromorphic invariants involving the cohomology for the sheaf of germs of pluriharmonic functions, the truncated holomorphic de Rham cohomology, and the de Rham cohomology. To define these invariants, by using a sheaf-theoretic approach, we establish a blow-up formula together with a canonical morphism for the Bott-Chern hypercohomology. In particular, we compute the invariants of some compact complex threefolds, such as Iwasawa manifolds and quintic threefolds.
Investigation of nonlinear optical responses of organic derivative of imidazole: imidazole-2-carboxaldehyde
Authors: Lakhera Shradha , Rana Meenakshi , Devlal Kamal
Published: May 2023

In the present work, we explored the nonlinear optical properties of imidazole-2-carboxaldehyde, which is an aromatic derivative of imidazole. Optimization has been performed for imidazole-2-carboxaldehyde using density functional theory with a B3LYP/6-311G basis set. To check the possible charge transfer, Mulliken charge analysis and molecular electrostatic potential analysis was performed. The chemical reactivity of the probe molecule was investigated by calculating different frontier molecular orbital parameters such that energy gap, ionization potential, electron affinity, chemical potential, electronegativity, softness, and hardness. Raman, Fourier transform infrared, and nuclear magnetic resonance analysis was also performed to study vibrational properties and UV–vis was performed to study the electronic properties of the compound. A high value of dipole moment (μ
total), polarizability (α), first-order hyperpolarizability (β), and Raman activity validates the NLO behavior of the compound. Thus, the performed computational study validates a strong candidature of imidazole-2-carboxaldehyde to be used as a non-linear optically active material in the future.
AlGaN/GaN heterostructures for high power and high-speed applications
Authors: Joshi Bhubesh Chander
Published: May 2023

AlGaN/GaN heterostructures are one of the most promising semiconducting structures for fabricating high-speed and high-power electronic devices such as high electron mobility transistors and heterojunction bipolar transistors. Due to the lack of native substrates, these epitaxial structures are generally grown on foreign substrate materials such as sapphire, SiC and Si by using two-step growth techniques. In this paper, a few test structures along with TLM pads, FET structure, ohmic contacts and Schottky contacts have been fabricated on AlGaN/GaN heterostructure by photolithography, reactive ion etching, and e-beam metallization. Transmission line measurement has been used to calculate the sheet resistivity and contact resistance of ohmic pads. Current voltage measurement is used to test an FET structure of size 1 × 150 µm2with a gate length of 4 µm and source to drain spacing of 5 µm.
A very rare cause of hypertrygliseridemia in infancy: a novel mutation in glycerol-3-phosphate dehydrogenase 1 (GPD1) gene
Authors: Gunes Dilek , Kalaycik Sengul Ozlem , Senturk Leyli
Published: May 2023

Objectives

Transient infantile hypertriglyceridemia (HTGTI) is caused by mutations in the glycerol-3-phosphate dehydrogenase 1 (GPD1) gene. HTGTI is characterized by hypertriglyceridemia, hepatomegaly, hepatic steatosis and fibrosis in infancy. Here, we reported first Turkish HTGTI patient with a novel mutation of GPD1, having hypertriglyceridemia, hepatomegaly, growth retardation and hepatic steatosis. He is the first case who needs transfusion until 6th month in GPD1.

Case presentation

A 2-month-27-day-old boy, who had growth retardation, hepatomegaly and anemia suffered to our hospital with vomiting. Triglyceride level was 1603 mg/dL (n<150). Liver transaminases were elevated and hepatic steatosis was developed. He needed transfusion with erythrocyte suspension until 6th month. Etiology could not be elucidated by clinical and biochemical parameters. A novel homozygous c.936_940del (p.His312GlnfsTer24) variant was detected in the GPD1 gene by Clinical Exome Analysis.

Conclusions

GPD1 deficiency should be investigated in the presence of unexplained hypertriglyceridemia and hepatic steatosis in children especially in infants.
New citizenship and the negotiation of the global/local interface: reflexivity, emotions, and metapragmatics
Authors: Vitorio Raymund
Published: May 2023

New citizens are typically characterized as people who occupy an estuarial position between the global and the local: to simultaneously become authentic to their global provenience and rooted in their new local societies, they are expected to cautiously partake in processes of differentiation as they construct their identities. This article investigates how new citizens negotiate this seemingly untenable position to present themselves as new citizens of Singapore who have negotiated the global/local dichotomy, rendering themselves as legitimate citizens. By adopting a metapragmatic approach, the article focuses on two object-signs that new citizens commonly deploy: familial relations and passports. The analysis traces how the semiotic potential of these object-signs is mediated by accounts of emotions, which are indispensable considerations of how signs realize their semiotic potential. Through situated reflexive practices, new citizens use these object-signs to equivocally and strategically manage supposed markers of difference, which consequently enables them to claim legitimacy as Singaporeans. These identities challenge regimented views about the global and local affordances of the notion of citizenship. This expands the semiotic range of good/new citizenship, which may prove instructive in understanding variegated understandings of citizenship not just in Singapore but also in other contemporary multicultural societies.
Moderation between Religious Freedom and Harmony Concerning the Regulation on Mosque Loudspeaker: Comparison between Indonesia and Other Muslim Countries
Authors: Riyanto Waryani Fajar
Published: May 2023

This research explains the comparison of regulations on mosque loudspeakers between Indonesia and Muslim countries in the world. Guidelines for the use of mosque loudspeakers in Indonesia are regulated in the Instruction of the Director-General of Islamic Community Guidance at the Ministry of Religious Affairs Number 101 of 1978 concerning Guidance on the Use of Loudspeakers in Mosques and Musala and the Circular Letter of the Minister of Religion Number 5 of 2022 concerning Guidelines for the Use of Loudspeakers in Mosques and Musala. Primary data of this study includes the 1978 Instructions and the 2022 Circular Letters. Secondary data is obtained from relevant literature sources and regulations on the use of mosque loudspeakers in several Muslim countries in the world, namely Saudi Arabia, Turkey, Syria, Bahrain, United Arab Emirates, Egypt, and Malaysia. This research finds the concept of moderation of regulations on mosque loudspeakers in Indonesia. The findings of this research can be used as a guide model for drafting the contents of mosque loudspeaker regulations in several Muslim countries around the world by relying on three moderate aspects regarding the rules of time (public morals), volume (public health), and sound quality of mosque loudspeakers (public convenience).
The crystal structure of fac-tricarbonyl((pyridin-2-yl)methanamino-κ2
N,N′)-((pyridin-2-yl)methanamino-κN)rhenium(I) nitrate, C15H16O3N4Re
Authors: Ramoba Lesetja V. , Alexander Orbett T. , Malan Frederick P. , Manicum Amanda-Lee E.
Published: May 2023

C15H16O3N4Re, triclinic, P1̄ (no. 2), a = 7.4939(2) Å, b = 10.1316(2) Å, c = 13.8351(3) Å, α = 103.453(2)°, β = 101.992(2)°, γ = 107.880(2)°, V = 926.98(4) Å3, Z = 2, R

gt
(F) = 0.0341, wR

ref
(F
2) = 0.0861, T = 150 K.
Magnetic and porous effects on steady state and flow resistance of Burgers fluids between parallel plates
Authors: Fetecau Constantin , Rauf Abdul , Mushtaq Tahir
Published: May 2023

Some motion problems of Burgers fluids between parallel plates are analytically and numerically investigated when magnetic and porous effects are taken into account and a differential expression of the non-trivial shear stress is prescribed on the lower plate. Closed-form expressions are determined for the non-dimensional steady state velocity and shear stress fields and the corresponding Darcy’s resistances. They are the first exact solutions for hydromagnetic motions of Burgers fluids through porous media when a differential expression of shear stress is given on the boundary. The results that have been obtained are used to get the necessary time to reach the steady state and to bring to light the influence of magnetic field and porous medium on the flow resistance of the fluid. They can immediately be particularized to provide exact solutions for similar motions of Oldroyd-B, Maxwell, second grade and Newtonian fluids. It was found that the steady state is rather obtained in the presence of a magnetic field or porous medium. In addition, the flow resistance of the fluid declines in the presence of a magnetic field and, as expected, increases through porous media.
ÉTICA Y VALORES EN LA PUBLICIDAD. EL BRANDED CONTENT COMO FORMATO ESTRELLA DE LA RESPONSABILIDAD SOCIAL CORPORATIVA
Authors: Pellicer Jordá María Teresa
Published: May 2023

La ética publicitaria está más de moda que nunca y se ha convertido en una rama importante dentro de la conocida como Responsabilidad Social Corporativa. Por este motivo, se está explorando de qué modo los distintos formatos publicitarios pueden adaptarse al nuevo objetivo de las empresas de transmitir los valores y propósitos de marca, de un modo eficaz. El branded content se posiciona como uno de los formatos estrella para este fin y de eso vamos a tratar en este artículo. Para ello, analizaremos las acciones de branded content que se han puesto en marcha en España en los últimos cuatro meses del año 2022, lo cual nos permitirá saber cuáles son las temáticas, géneros, formatos y tipos de empresas que lo utilizan, así como las ventajas y limitaciones de su uso.
Control of fibrosis with enhanced safety via asymmetric inhibition of prolyl‐tRNA synthetase 1
Authors: Yoon Ina , Kim Sulhee , Cho Minjae , You Kyung Ah , Son Jonghyeon , Lee Caroline , Suh Ji Hun , Bae Da‐Jeong , Kim Jong Min , Oh Sinae , Park Songhwa , Kim Sanga , Cho Seong Hyeok , Park Seonha , Bang Kyuhyeon , Seo Minjeong , Kim Jong Hyun , Lee Bongyong , Park Joon Seok , Hwang Kwang Yeon , Kim Sunghoon
Published: May 2023

Prolyl‐tRNA synthetase 1 (PARS1) has attracted much interest in controlling pathologic accumulation of collagen containing high amounts of proline in fibrotic diseases. However, there are concerns about its catalytic inhibition for potential adverse effects on global protein synthesis. We developed a novel compound, DWN12088, whose safety was validated by clinical phase 1 studies, and therapeutic efficacy was shown in idiopathic pulmonary fibrosis model. Structural and kinetic analyses revealed that DWN12088 binds to catalytic site of each protomer of PARS1 dimer in an asymmetric mode with different affinity, resulting in decreased responsiveness at higher doses, thereby expanding safety window. The mutations disrupting PARS1 homodimerization restored the sensitivity to DWN12088, validating negative communication between PARS1 promoters for the DWN12088 binding. Thus, this work suggests that DWN12088, an asymmetric catalytic inhibitor of PARS1 as a novel therapeutic agent against fibrosis with enhanced safety.
Learning To Promote Students’ Mathematical Curiosity And Creativity
Authors: Rahayuningsih Sri , Ikram Muhammad , Indrawati Nenny
Published: May 2023

[Background] Discovery learning is a model that guides students to actively learn in finding concepts or knowledge through an inquiry process based on the data or information obtained from experiments or observations. [Objective] The present study examined the implementation of a modification of discovery learning using mind mapping in promoting students’ mathematical curiosity and creativity. [Method] A Classroom Action Research (CAR) design was employed in this study. The participants were 250 students in Middle Indonesian who registered in the academic year of 2020/2021. [Results] The descriptive analysis showed that the students achieved an average score of 44.04 with a standard deviation of 18.716 in pre-CAR, 52.48 with a standard deviation of 22.978 after cycle I, and 76.72 with a standard deviation of 17.097 after cycle II. Based on the students’ mathematical creative thinking scores, 2 (8%) students could perform creative thinking in pre-CAR, 6 (24%) students after cycle I, and 22 (88%) students after cycle II. These figures indicated that the students classically achieved the ability to think creatively in mathematics after cycle II. [Conclusion] It was concluded that the implementation of modified discovery learning and mind mapping could promote students’ mathematical creative thinking ability. The interview results also suggest that the learning model could increase mathematical curiosity of both the low and high achievers.
Examining the Characteristics of Anatomy and Biometry of Crataegus azarolus,
Authors: Tichi Ali Hassanpoor , Gholamiyan Hadi
Published: May 2023

This report discusses the biometry and microscopic features of Crataegus azarolus wood fibers. A Crataegus azarolus tree was selected and cut from the gardens of Neka city (Mazandaran province). At a breast height, 2.5 m and 3.5 m height, three 5 cm thick disks were prepared and in the transverse direction, the test samples were cut and evaluated sequentially 2 x 2 cm long by 3 cm long from the pith to the bark. The anatomical properties of C. azarolus wood were studied using a light microscope. Wood anatomical features of C. azarolus are as follows: diffuse-porous with multiple vessel grouping in the radial direction (in most cases), homogenous rays, simple perforation plates, alternate intervessel pits, and the average length of vessel elements shorter than 350 microns. There was a significant difference in the fiber length, fiber diameter, fiber lumen diameter, and fiber wall thickness, both in the transverse direction and in the longitudinal direction of the Crataegus azarolus tree stem. The biometric properties of the fibers increased from the pith to the bark. The average fiber length, fiber diameter, fiber lumen diameter, and cell wall thickness of the fibers were 0.78 mm, 22.53 µm, 18.6 µm, and 4.5 µm, respectively.
Artificial neural networks-based simulation of obstacle detection with a mobile robot in a virtual environment
Authors: Crnokic Boris , Peko Ivan , Grubisic Miroslav
Published: May 2023

Mobile robot navigation is primarily a task that occurs in a real environment. However, simulating obstacles and robot movements in a virtual environment can provide significant advantages and yield good results, as demonstrated in this paper. By employing artificial neural networks (ANNs), it is possible to develop a trained system in a virtual environment that can detect obstacles using data collected from various sensors. In this study, infrared (IR) sensors and a camera were utilized to gather information from the virtual environment. The MatLab Simulink software package was used as a tool to train the artificial neural networks. Detection and avoidance of obstacles were simulated in the RobotinoSIM virtual environment.
Redvyntsi — the Funeral and Memorial Complex of a Rider of the Scythian Period in Northern Podillia
Authors:   PhD, Senior Research Fellow, the Institute of Archaeology, the National Academy of Sciences of Ukraine, the Early Iron Age Archaeology Department, Mohylov Oleksandr , Hutsal Vitalii ,   PhD, Head of the Archaeological laboratory, Kamianets-Podilskyi National University
Published: May 2023

In 1973, the archaeological expedition of Kamianets-Podilskyi Pedagogical Institute under the leadership of A. F. Hutsal and I. S. Vynokur investigated the mound no. 1 near Redvyntsi village in Khmelnytskyi District and Oblast, in the upper reaches of the Southern Buh basin. The graveyard of five mounds was located 0.5 km southwest from Redvyntsi, on the territory of the collective farm garden. The height of the embankments, located 50—60 m from each other, was 1.8—2.7 m, the diameter — 14—18 m. The height of the mound no. 1 (the biggest in the group), located in the eastern part of the burial ground, was 2.5 m, the diameter — 18 m. A burial and memorial complex was discovered under the mound: the cenotaph. It had a wooden structure with a diameter of 4.4 m. It was located on the top of the soil filling. In the centre of the layout there was a complex of items. On the side, traces of ritual hearths and ceramics near them were found. Among the finds, bridle items made of bronze should be noted. Moreover, there were plates that had the shape of a circle, a rosette and and a diamond. Buckles were found with them. Weapons include an iron spearhead and bronze three-bladed arrowheads. A glass bead was found among the jewellery. The finds have analogies in many areas of the Northern Black Sea region during the Scythian period: the Eastern Podillia group, the Dnipro River Right-bank forest-steppe region, the Ukrainian Left-bank forest-steppe, the Middle Don region and Steppe Scythia. Mound no. 1 in Redvyntsi, due to the lack of a burial, can be interpreted as a cenotaph: during the construction of which fire rituals took place, which have comparisons in the Ukrainian forest-steppe. According to analogies, the burial mounds in Redvyntsi can be dated by the 4th century BC. The significant size of the mound, as well as the rich inventory, indicate that it was built in the memory of an ancient warrior-horseman. The deceased, who could have died in a foreign land, probably belonged to the local nobility, and headed one of the communities of the Scythian period, which lived in the 4th century BC in the upper reaches of the Southern Buh.
Inscriptions in Hebrew on Ceramic Ware of the 17th—18th Centuries
Authors:   DSc, Associate Professor, Rivne State Humanitarian University, Pryshchepa Bohdan , Rusakova Yulia ,   PhD, Assistant Professor, Reichman University (IDC Herzliya), Tiomkin School of Economics, Chmil Lesia ,   PhD, Research Fellow of the Institute of Archaeology, National Academy of Sciences of Ukraine
Published: May 2023

In the article the authors deal with the verification, attribution and introduction into scientific circulation of a number of Hebrew inscriptions on Early Modern ceramic vessels. This issue has not been raised in the Ukrainian archaeological publications yet. Such isolated inscriptions were previously wrongly interpreted as potters’ marks. More than a dozen of vessels with inscriptions in Hebrew are known today. In particular, they were found during the excavations of three cities — Bila Tserkva, Kyiv, Ostroh. These are fragments of three plates, two small and one large mugs, which come from the cellar of the first half of the 17th century in Ostroh, two plates and a mug from the building of the late 17th — early 18th centuries in Bila Tserkva, as well as a pot from the building of the 17th century in Kyiv. Two groups of inscriptions can be distinguished. The first one is Passover inscriptions on vessels that were obviously intended for the Passover Seder (a symbolic set of products for a holiday supper) or for daily usage during the holiday. Using an additional set of vessels to the holiday is explained by kashrut norms and specific prohibitions of kvass use. The mug with an inscription “kimkha de Piskha” (“flour for Pesach”) belongs to the second group. It was associated exclusively with religious needs and was intended for the collection of donations (tzadaka) on Passover. Tzadaka as a religious obligation to perform charity laid at the basis of the Jewish community existence. It led to the proliferation of different types of money boxes for collecting donations. In general, the topic requires detailed investigations with the involvement of additional archaeological materials, interpretation and introduction of hitherto unpublished materials into scientific circulation.
Implementing a Post-Discharge Telemedicine Service Pilot to Enhance the Hospital to Home Transition
Authors: Haimowitz Rachel L. , Halley Tina V. , Driskill Christina , Kendall Morgan , Parikh Kavita
Published: May 2023

OBJECTIVES

The objectives of this study are to (1) describe our postdischarge telemedicine program and (2) evaluate program implementation.

METHODS

At our single-center tertiary care children’s hospital, we launched our postdischarge telemedicine program in April 2020. We used the Template for Intervention Description and Replication framework to describe our pilot program and Proctor’s conceptual framework to evaluate implementation over a 9-month period. Retrospective chart review was conducted. Descriptive analyses were used to compare demographics and health care reutilization rates across patients. Implementation outcomes included adoption (rate of scheduled visits) and feasibility (rate of completed visits). Effectiveness outcomes included the rate of postdischarge issues and unscheduled healthcare utilization.

RESULTS

We established a postdischarge telemedicine program for a general pediatric population that ensured follow-up at a time when in-person evaluation was limited because of the coronavirus disease 2019 pandemic. For implementation evaluation, we included all 107 patients in the pilot program. Adoption was 100% and feasibility was 58%. Eighty-two percent of patients completing a visit reported one or more postdischarge issues. There was no difference in health system reutilization between those who completed a visit and those who did not.

CONCLUSIONS

Implementation of a postdischarge telemedicine service is achievable and promotes early detection of failures in the hospital to home transition. Directions for future study will include rigorous program evaluation via telemedicine program assessment tools and sustainability efforts that build upon known implementation and health service outcomes.
The Interpretation and Reconstruction of the Process of the Japanization of Confucianism: A Case Study on the Kyoto Faction of Zhu Xi Studies in Tokugawa Japan
Authors: Liu Ying
Published: May 2023

The concept of the ‘Japanization of Confucianism’ took shape during the Meiji 明治 period (1868–1912 C.E.), reached its highest point of development in Tokugawa Japan (1603–1868), and is epitomized by the rise of the Kyoto faction (Kyō-gakuha 京學派) of Zhu Xi studies (Shushi-gaku 朱子學). However, due to the underestimation of Japanese Zhu Xi studies by scholars like Inoue Tetsujirō 井上哲次郎 from the early twentieth century onward, the Kyoto faction ipso facto has been largely eclipsed in the history of the study of Japanese Confucianism. In light of this, the present article investigates the representative scholars in the Kyoto faction to uncover the dynamic process of Confucianism’s penetration into Japanese society. A multiple-dimension study is conducted to dissect varied approaches to promoting the Japanization of Confucianism, including the vernacularization and sanctification of Confucianism in Japan. This article seeks to redefine the role of the Kyoto faction in the transmission of Confucianism across East Asia.
Epeút- és epehólyag-gyulladás: diagnosztikus kritériumok és terápia
Authors: Czakó László , Gyökeres Tibor , Hritz István , Madácsy László , Illés Dóra , Szepes Zoltán , Dubravcsik Zsolt , Péterfi Zoltán , Nagy András , Szücs Ákos , Vincze Áron
Published: May 2023

Az epehólyag és az epeutak betegségei a leggyakrabban előforduló tápcsatornai
kórképek közé tartoznak a fejlett országokban. Az epehólyag, illetve az epeutak
heveny gyulladása potenciálisan súlyos, akár életet veszélyeztető állapot,
melynek kezelése a kórkép azonnali felismerését és időben elkezdett
multidiszciplináris ellátását igényli. Bár gyakori kórképekről van szó, az
ellátás mégsem egységes hazai szinten. Az evidenciaalapú szakmai ajánlás célja a
fenti kórképek diagnosztikus és súlyossági kritériumainak áttekintése, valamint
a számos, rendelkezésre álló terápiás lehetőség indikációinak és alkalmazási
szabályainak ismertetése. A jelen szakmai ajánlást a Magyar Gasztroenterológiai
Társaság Endoszkópos Szekciójának vezetősége készítette a társszakmák jeles
képviselőinek – sebész, infektológus, intervenciós radiológus – konszenzusa
alapján, átlátható, a gyakorlatban hasznosítható fogódzót nyújtva a mindennapi
betegellátás során. Ajánlásunk a japán vezető szakemberek által 2007-ben
összeállított, majd nemzetközi szakértőkkel 2013-ban (TG13) és legutóbb 2018-ban
(TG18) aktualizált Tokió-irányelveken alapul. Orv Hetil. 2023; 164(20):
770–787.
Investigation of the Therapeutic Value of Verbascum pyramidatum Bieb. for Obesity
Authors: SENER Sıla , BADEM Merve , ÇATALBAŞ Mehmet , KANBOLAT Şeyda , ÖZGEN Ufuk , ULAŞ ÇOLAK Nevin
Published: May 2023

Nowadays, one of the therapeutic approaches for obesity is the use pancreatic lipase inhibitors which reduce the digestion and absorption of fats. Most research indicates that natural sources which have a lipase inhibitory effect, may be utilized to treat obesity. Verbascum pyramidatum is one of the potential natural sources for obesity, and it has been demonstrated to have anti-inflammatory, antidiabetic, and regulatory effects on lipid metabolism. With this study, V. pyramidatum's potential lipase inhibitor effect, it is aimed to reveal its value in the treatment of obesity.

In vitro spectroscopic method was used to determine the lipase inhibitory effect of V. pyramidatum. The quantitative investigation of V. pyramidatum's phenolic metabolites with antiobesity activity was carried out utilizing the Reverse Phase-High Performance Liquid Chromatography method.

In this reported study, it was proven that extract and all fractions had an impact that inhibited lipase, with the ethyl acetate extract showing the highest inhibitory effect. Additionally, it was revealed through HPLC analysis that the species included p-OH benzoic acid, coumaric acid, quercetin, sinapic acid, and syringaldehyde. It has been demonstrated that V. pyramidatum may be a promising candidate for obesity treatment, but further investigations are required to use it as a therapeutic agent.
Asymmetric Dynamics of Inflation Inertia in Some Selected Non-Eurozone European Countries
Authors:   Karamanoglu Mehmetbey University, Özcan Mehmet
Published: May 2023

Relevance. Inflation inertia refers to the persistence of inflation over time and can be caused by a variety of factors, including expectations about future inflation, the structure of the economy, and the behavior of economic agents. Over the past two decades, the European economy has grappled with a range of challenges and currently seeks to mitigate the negative impacts of the global pandemic. Research objective. Persistent inflation can lead to uncertainty, decreased investment, and a loss of confidence in an economy. Non-eurozone economies can also face challenges in controlling inflation due to such factors as the lack of monetary integration with the eurozone, limited access to the European Central Bank's resources, and the lack of a unified currency. Hence, for a more effective monetary policy in these countries, it is necessary to measure and understand the inflation inertia. This paper offers a novel empirical study of the dynamics of inflation inertia for seven EU economies that are not part of the eurozone. Data and methods. To achieve the research objective, three non-linear unit root tests are employed to consider both structural changes and regime switching. These tests allowed for the inclusion of almost all non-linear dynamics observed in the inflation series. In addition, the tests involve the use of the dynamic rolling windows sample approach in order to provide more sensitive measurements of the effect of time-varying shocks on inflation inertia. Results. According to the static sample analysis of 200 observations, Bulgaria, Croatia, and the Czech Republic have inflation inertia. Sweden, Romania, Hungary, and Poland do not have inflation inertia when non-linear regime switching dynamics and structural change are considered. However, Croatia and the Czech Republic show a mostly non-stationary inflation in dynamic rolling windows sampling. Hungary has persistent inflation even though it was not detected in the static sample analysis. The shocks of inflation fade out in Bulgaria, Poland, Romania, and Sweden with non-linear dynamics. If non-linear dynamics is ignored, it can lead to misleading results in economic time series. Conclusions. Inflation inertia can be influenced by a variety of factors, including the global pandemic, global or regional conflicts and monetary policy preferences. The successful management of inflation inertia in Romania and Sweden may serve as a model for other economies that have demonstrated an ability to effectively address and mitigate the challenges posed by inflation inertia.
FDI Flows in resource-rich countries: does the quality of institutions matter?
Authors:   Ural Federal University, Valei Azamat M. , Mamman Suleiman O. ,   Ural Federal University,   Gusau Federal University
Published: May 2023

Relevance. Foreign investment is likely to be attracted to resource-rich countries because of their wealth of natural resources. However, the fact that foreign direct investment (FDI) contributes less than 10% of these countries’ GDP indicates that FDI has a non-proportional impact when compared to the size of the natural resources. Hence, it is critical to identify the missing link impeding resource optimization through FDI. Research objective. Given the significance of FDI, the study seeks to ascertain whether the quality of institutions in resource-rich countries influences FDI inflows. This is significant because resource-rich countries may have other factors that encourage FDI but do not result in resource optimization. Data and methods. The study employed panel data analysis to analyze the impact of FDI on economic growth in resource-rich countries and the role of institutions in attracting FDI. The study relies on the Augmented Mean Group Estimator and on the annual data from the World Bank's World Development Indicator and the World Bank's World Governance Indicator for the top ten resource-rich countries. Results. Our preliminary evidence indicated that FDI had a positive and significant effect on economic growth in resource-rich countries. The extent of the influence, on the other hand, is minimal for all categories of countries. Our main results revealed that institutional quality has a significant pull effect on FDI, with trade openness playing a key role, particularly in resource-rich nations with well-developed institutions. Conclusions. We found that institutional quality plays a critical role in attracting FDI, which could have hampered natural resource optimization. Furthermore, countries with high institutional quality and less restrictive investment policies attract more foreign direct investment (FDI) than countries with low institutional quality and with investment policies ranging from moderate to restrictive. In general, resource-rich countries, particularly those with weak institutional qualities, should address the gap in institutional quality to attract more inward investment.
Transparência, accountability e governance: revisão sistemática da literatura nos hospitais públicos
Authors: Nunes Carlos , Gomes Patrícia , Santana Joaquim
Published: May 2023

Resumo Neste estudo busca-se desenvolver uma revisão da literatura baseada na análise bibliométrica sobre o tema da transparência e da accountability no contexto da governance dos hospitais públicos, procurando identificar linhas de investigação, teoria, método de investigação e lacunas existentes por intermédio da análise das publicações científicas datadas até 2020. A investigação seguiu o referencial teórico da transparência e da accountability no setor público com o intuito de compreender o seu enquadramento no contexto da governance dos hospitais. Com recurso ao software Bibliometrix e terminado o processo de consulta dos artigos nas bases de dados Scopus e WoS, foram selecionados 118 artigos para este estudo. Constatou-se que, no período entre 2017-2020, cerca de 85% das publicações são de base qualitativa e há uma tendência crescente no estudo da transparência e da accountability na governança dos hospitais públicos. A transparência surge frequentemente interligada à responsabilização dos agentes (accountability), às políticas de comunicação externa (relatórios públicos) e interna, assim como à sua compreensibilidade. Verificou-se a ainda predominância das publicações de origem norte-americana e chinesa. O estudo identifica também a escassez de investigação baseada em modelos quantitativos que explorem relações de dependência entre as dimensões estudadas, limitando a compreensão da interdependência entre as práticas de transparência e os atributos internos e externos das organizações. O estudo contribui para o conhecimento sobre interações entre transparência, accountability e prestação de contas na governança dos hospitais públicos.
MATERIALISMO HISTÓRICO E DIALÉTICO: ENTRE APROXIMAÇÕES E TENSÕES
Authors: Coelho Bruna da Penha de Mendonça
Published: May 2023

Resumo Este artigo objetiva dialogar com os pressupostos valorativos e metodológicos do materialismo histórico e dialético, estruturando-se em duas partes. A primeira diz respeito à compreensão desse método em eixos centrais e imbricados da obra de Marx (crítica da economia política, condições de surgimento do capitalismo, processo revolucionário e luta de classes). A segunda parte propõe uma análise comparativa e não estanque de possíveis tensões e aproximações com relação a escolhas metodológicas durkheimianas e weberianas, especialmente quanto à precedência entre indivíduo e sociedade, bem como quanto às preconcepções de mundo dos pesquisadores e às relações entre saber científico e ação política.
Estudo descritivo de casos notificados de febre maculosa em São Paulo, Rio de Janeiro e Minas Gerais entre 2007 e 2016
Authors: Rodrigues Cláudio Manuel , Geise Lena , Gazeta Gilberto Salles , Oliveira Stefan Vilges de
Published: May 2023

Resumo Introdução A febre maculosa é uma doença infecciosa aguda causada por bactérias do gênero Rickettsia e transmitida por carrapatos que pode levar à hospitalização e, eventualmente, a óbito por causa de quadros mais graves. Objetivo O objetivo deste artigo foi descrever o cenário epidemiológico da doença nas três unidades federativas de maior número de notificações e óbitos pela doença no Brasil entre 2007 e 2016. Método Estudo epidemiológico descritivo com base nos dados das fichas de investigação para a doença, sendo analisados dados demográficos, geográficos, ambientais e de hospitalização, diagnóstico e desfecho dos casos na área de estudo. Resultados Foram confirmados 953 casos da doença, em sua maioria por critérios laboratoriais, sendo observada maior prevalência entre homens com idade média de 35 anos, pouco relacionados ao ambiente de trabalho, mas amplamente relacionados ao meio urbano. Do total de casos confirmados, 64% pacientes afirmaram ter tido algum contato com carrapato, assim como com cães (36%), capivaras (20%) e equinos (19%). Conclusão Existem questionamentos a respeito da doença que não foram elucidados neste artigo, entretanto abordagens criativas, validadas e ancoradas na associação de áreas de conhecimento distintas poderão dar bons resultados se objetivamente aplicadas em ações estratégicas da gestão da saúde.
Jovens mulheres rurais estudantes das ciências agrárias: não querem ou não têm oportunidade de serem sucessoras?
Authors: Breitenbach Raquel
Published: May 2023

Resumo A presente pesquisa teve como objetivo identificar as intenções e perspectivas acerca da sucessão familiar das jovens mulheres estudantes dos cursos das ciências agrárias e áreas afins do Instituto Federal do Rio Grande do Sul (IFRS), no Campus Sertão. O artigo focou na discussão de gênero, buscando suprir uma lacuna em estudos sobre sucessão, já que é uma dimensão pouco examinada. Participaram da pesquisa 386 jovens mulheres rurais estudantes de cursos das ciências agrárias, as quais responderam um questionário fechado, elaborado com respostas em escala Likert de 5 pontos. Os dados foram tabulados e analisados estatisticamente no Programa para Análise Estatística de Dados Amostrados (PSPP), com análises descritiva e teste Chi-Square. Os resultados apontaram que as jovens mulheres encontram um ambiente familiar pouco favorável para serem sucessoras, especialmente por: receberem menos incentivo dos pais, sobretudo das mães, para permanecerem no campo e serem sucessoras; terem menos oportunidade de participação nas atividades operacionais e gerenciais da propriedade. Consequentemente, essas jovens têm menos interesse em serem gestoras e sucessoras da propriedade rural dos pais. A presente pesquisa concluiu que, mesmo que as jovens rurais desejassem ser sucessoras ou permanecer no campo, não é oportunizado a elas a mesma condição de igualdade, comparativamente aos jovens homens, para que se preparem e se sintam acolhidas ou desejadas como sucessoras.
Morphological variations of the labial frenum, type of attachment and presence of diastemas: integrative review
Authors: SANTOS Aline , SILVA Lindinalva Marielly , LIMA Isabela , OLIVEIRA Lívia Maria Lopes de , VAJGEL Bruna de Carvalho Farias , CIMÕES Renata
Published: May 2023

ABSTRACT Objective: The aim of the present literature review was to compile data on the frequency of morphological and attachment types of the upper and lower labial frenum in different populations and investigate the association between the attachment level of the upper labial frenum and the occurrence of diastemas. Methods: Searches were conducted between May and June 2021 in the Medline (via Ovid), Google Scholar and CAPES databases. Thirty-eight studies that evaluated frenum morphology, frenum morphology and attachment or frenum morphology, attachment and the occurrence of diastemas were selected for the extraction of data. Results: Based on the data compiled in this review, the most common morphological and attachment types were labial frenum normale and mucosal attachment. The papillary and papilla penetrating types of attachment were more associated with the occurrence of diastemas. Conclusion: Longitudinal studies are needed to investigate this correlation in children and adults.
Intervention group logotherapy and performance measures for reducing phubbing in Generation Z
Authors: Fatchurahman Mohammad , Setiawan Muhammad Andi , Karyanti Karyanti
Published: May 2023

Abstract Objective This study aims to explore in-depth how to apply logotherapy to people with phubbing. Methods The research methodology uses with mixed methods, a sequential approach used in this study for handling the phubbing population is 110 students. Samples taken by purposive sampling with attention to the range aged 10-25 years, and the research sample obtains as many as 16 students. The sample was determined based on the scale analysis results and recommendations from the school – research data from research instruments in observation sheets and qualitative data interviews. A Phubbing scale was used to get quantitative data. Results The results of the study showed that there were better changes as evidenced by changes in phubbing scale scores before and after being given treatment. Conclusion The study’s conclusion shows that Logotherapy Counseling effectively reduces phubbing in Generation Z.
Uso excessivo de internet e smartphone e problemas emocionais em estudantes de psicologia e psicólogos
Authors: Andrade André Luiz Monezi , Scatena Adriana , Bedendo André , Machado Wagner de Lara , Oliveira Wanderlei Abadio de , Lopes Fernanda Machado , Micheli Denise De
Published: May 2023

Resumo Objetivo Este estudo teve por objetivo avaliar a prevalência de dependência de internet, seus principais preditores e a associação com problemas emocionais em estudantes de psicologia (n = 1.916) e psicólogos (n = 4.359). Método Os indivíduos preencheram um questionário sociodemográfico e outros instrumentos específicos. Observou-se que 9,3% dos estudantes e 4,0% dos psicólogos foram detectados com uso excessivo de internet. Resultados Todos os participantes com uso excessivo de internet apresentaram uma frequência significativamente maior de sintomas de depressão, ansiedade e estresse, e estes problemas foram preditores para a dependência de internet somente entre os psicólogos. Conclusão Compreender o padrão de dependência de internet pode ajudar no desenvolvimento de políticas públicas específicas para esses indivíduos.
Repellent activity of essential oils against mediterranean fly and their effects on postharvest quality in paluma guava
Authors: Gonzaga Kennedy S. , de Brito Carlos H. , Salustino Angélica da S. , de Souza Maria Í. A. , Santos João P. de O. , Sousa Francisco de A. R. da M.
Published: May 2023

ABSTRACT Brazil is one of the world's largest guava (Psidium guajava) producing countries, but the economic performance of this crop can be negatively affected by the damage caused by Ceratitis capitata (Diptera: Tephritidae). The main methods for controlling C. capitata are based on broad-spectrum insecticide applications. However, the negative effects of using this control method stimulate the development of sustainable alternatives, such as the use of essential oils (EO). In this sense, the objective of the present study was to evaluate the repellent activity of EO of citronella (Cymbopogon nardus), clove (Syzygium aromaticum), and copaiba (Copaifera officinalis) for repellency of C. capitata in Paluma guava fruits and determine their effects on postharvest fruit quality, under laboratory-controlled conditions. The fruits were treated with citronella, clove, and copaiba EO and placed in covered plastic containers attached to the ends of arenas of 20 cm diameter and 15 cm height. The fruit physical and chemical analysis was carried out based on the same oils applied in the repellent test. The C. nardus essential oil presented a greater repellency of C. capitata females. The EO applications proved to be a good strategy for maintaining the fruit post-harvest quality.
Genetic parameters in melon sub-accessions from traditional agriculture
Authors: de Amorim Clisneide C. , de Queiroz Manoel A. , Barbosa Bárbara L. R. , Coutinho Milena dos S. , Lima Neto Izaias da S.
Published: May 2023

ABSTRACT Family farming in Brazil holds a high diversity of melon germplasm, composing an important source of alleles for breeding programs. Thus, the objective of this study was to estimate genetic parameters and select genotypes from a population of melon sub-accessions from different botanical varieties grown by family farmers, based on morphological parameters. Two experiments were conducted, one in 2019 and another in 2020, in a complete randomized block design, with three replications and five plants per plot, using 27 melon sub-accessions (generation S2) from family farmers, and a commercial variety. Nine quantitative descriptors were evaluated. Assumptions of ANOVA were tested, followed by individual and joint analyses of variance. Significant differences were found among sub-accessions for all descriptors evaluated, with heritabilities higher than 83% and significant genotype-environment interactions for 88.8% of the characteristics evaluated. Thus, genetic variability was found among sub-accessions, with predominance of genetic effects over environmental effects, denoting the possibility to obtain genetic gains by the improvement of several characteristics of agronomic interest. The sub-accessions BGMEL66.0, BGMEL111.0, and BGMEL112.0 are recommended for inclusion in breeding programs focused on obtaining good prolificacy and small fruits with high soluble solid contents. BGMEL sub-accessions (108.3 and 108.5) can generate progenies with high prolificacy, and sub-accessions of the variety momordica can be used for generation of progenies focused on shortening the crop cycle and increasing fruit size.