bluuebunny/crossref_metadata_2025 huggingface dataset:
Persepsi Masyarakat Kota Palembang Terhadap Pembubaran FPI
Authors: Autaria Ganeta , Yazwardi Yazwardi , Mikail Kiki
Published: September 2022

Penelitian ini berangkat dari permasalahan 1) bagaimana persepsi masyarakat Kota Palembang terhadap pembubaran FPI? 2) Bagaimana sikap masyarakat Kota Palembang terhadap pembubaran FPI?. Data penelitian diambil dengan instrumen angket dimana penulis menyebarkan kuesioner melalui google form. Penyimpangan dari ideologi Pancasila dengan aksi yang dilakukan kepada Pemerintah dan pada akhirnya Pemerintah melakukan tindakan tegas atas organisasi yang dipimpin oleh Rizieq Syihab, sehingga pada tanggal 30 Desember 2020 Pemerintah secara resmi membubarkan FPI diseluruh Indonesia termasuk di Provinsi Sumatera Selatan, salah satu undang-undang yang dilanggar yaitu UU nomor 16 tahun 2017.Berdasarkan kenyataan tersebut penulis ingin mengetahui persepsi masyarakat Kota Palembang terhadap pembubaran FPI, dimana FPI merupakan organisasi yang memainkan peran amar ma’ruf nafi munkar. Berdasarkan teori persepsi sosial yang bersif at selekt if , pemilihan persepsi yang bersif at selekt if mengingat persepsi masyarakat atas suatu objek yakni pembubaran ormas FPI. Dari hal tersebut penulis ingin melihat persepsi masyarakat terhadap keputusan Pemerintah yang membubarkan FPI.Hasil penelitian ini menunjukkan dengan data yang diolah menggunakan SPSS yaitu Ada pengaruh persepsi masyarakat secara simultan berpengaruh positif dan signifikan terhadap pembubaran FPI. Dilihat dari hasil persepsi masyarakat gerakan yang dilakukan FPI mendominasi jawaban yang setuju dan kurang setuju, sedangkan pada variabel pembubaran FPI didapatkan distribusi jawaban yang mendominasi setuju dalam item pernyataan ke 4 bahwa Pembubaran FPI telah sesuai Undang- Undang yang berlaku dikarenakan Indonesia merupakan Negara yang memiliki beberapa Agama.
Efektifitas Program CSR Hidroponik Rakit Apung Terhadap Peningkatan Taraf Hidup Penerima Manfaat Program
Authors: Poetri Izmi Dwi Maharani
Published: September 2022

A company, in implementing a CSR program, aims to meet the needs of the community as beneficiaries of the CSR program. However, in practice, the expected results are often not obtained so that the main objectives of the program are not achieved. Program Hidroponik Rakit Apung in Kelurahan Mariana and LPP Kelas II A Palembang aims to increase people's income through hydroponic vegetable agribusiness. But then another problem arose. Hydroponic installations that use    pipes as planting media are quite expensive. Starting from seeds, installation of    pipes, rockwool, planting media, nutrition, and so on. So that an innovation emerged, namely the application of Hidroponik Rakit Apung using styrofoam. This then raises the question of the effectiveness of its implementation in improving the living standards of program beneficiaries. This research found that the Hidroponik Rakit Apung community development program had an impact on the energy efficiency of 109.8 KwH, emission reduction of 0.97722 Ton Co2eq, water efficiency of 300 liters, and utilization of Non-B3 waste of 21.6 kg. If assessed from the economic side, the saving value from energy use efficiency is Rp. 734,391, and the saving value from water use efficiency is Rp. 6,840. Based on the results obtained, the replacement of hydroponic installations that originally used pipes, to later become floating rafts or used Styrofoam, is considered effective and can improve people's lives.
META-ANALISIS PENGARUH PENGGUNAAN MODEL PEMBELAJARAN TEAMS GAMES TOURNAMENT (TGT) TERHADAP HASIL BELAJAR SISWA
Authors: Lestari Novi Indah , Razak Abdul , Lufri Lufri , Zulyusri Zulyusri , Arsih Fitri
Published: September 2022

The purpose of this study was to analyze the effect of using the Teams Games Tournament (TGT) learning model on student learning outcomes. This research method is a meta-analysis by examining data sources originating from national or international journals published in the last seven years (2014-2021). This research begins with formulating the topic to be studied, then formulating the problem and research objectives, at the next stage collecting relevant articles to collect data. The data was obtained from online journal searches through Google Scholar. The keywords used are "Teams Games Tournament learning model" and "learning outcomes". From the search results there are 20 articles. Data were obtained and reanalyzed using quantitative methods. Based on the results of the analysis of the Teams Games Tournament learning model, it is proven to be able to improve student learning outcomes with significant results after being given treatment, which is 69.93% compared to the results before being given treatment, which is 55.75% so that it increases by 14.18%.
INOVASI GURU DALAM MENGEMBANGKAN KONTEN EDUKASI PLATFORM YOUTUBE SEBAGAI MEDIA PEMBELAJARAN BIOLOGI
Authors: A�yuni Qurrotul , Rizqi Fifin Naili , Aiyuni Feby , Rahmah Nazilatur , Fauzi Imron
Published: September 2022

The purpose of this study was to determine the concept of teacher innovation in developing educational content on the YouTube platform as a learning medium and to determine the form of educational content that can be used as a medium for learning biology. This study was designed using a qualitative method with the type of library research. The data analysis procedure was carried out by searching, collecting, and processing various valid sources such as printed books, e-books, and similar e-journals as article references. The result of this study is that teachers have a great opportunity to innovate and develop learning media in the develop learning media in the form of educational content on the YouTube platform in learning biology. The development of educational content is useful for increasing student interest in learning, making it easier for students to receive biology material, and providing opportunities for students to study wherever and whenever. Educational content can be in the form of learning videos, teaching videos, tutorial videos, and even animated videos. The conclusion of this study is that teachers can develop content in various forms freely as a medium for learning biology on the condition that the content contains information on biological knowledge.
ETIKA MUHADDITSIN DALAM MENERIMA DAN MENYAMPAIKAN HADIS DAN URGENSINYA TERHADAP KUALITAS HADIS
Authors: Samrida Samrida , Yusrina Elfa , Wendry Novizal
Published: September 2022

Muhaddits dalam menerima dan menyampaikan hadis harus sesuai dengan ketentuan-ketentuan yang telah ditetapkan oleh para ulama hadis, sehingga dalam penyampaian dan penerimaan hadis sesuai dengan ketentuan-ketentuan yang telah ditetapkan oleh para ulama hadis seperti ikhlas dan jujur lain-lain. Dalam perspektif etika ketentuan-ketentuan yang dibuat oleh para ulama hadis tersebut agaknya berbeda dengan prilaku yang diterapkan oleh para periwayat dalam kehidupan sehari-harinya, seperti Abdurrahim bin Zaid. Abdurrahim bin Zaid dikenal sebagai seorang periwayat yang pendusta. Hadis-hadis yang diriwayatkan oleh Abdurrahim bin Zaid kebanyakan di tolak sebab sebab kedustaannya. Dalam artikel ini penulis bertujuan untuk menelaah lebih lanjut tentang penerimaan dan penyampaian hadis dalam perspektif etika. Pada penelitian ini penulis menggunakan jenis penelitian kepustaaan (Library Riseach), dengan menggunakan metode deskriptif analisis dengan pendekatan etika. Berdasarkan pada hasil penelusuran penulis tentang penerimaan dan penyampaian hadis dalam perspektif etikan menunjukkan bahwa muhaddits dalam menerima dan menyampaikan hadis harus sesuai dengan kaedah yang telah di tetapkan oleh ulama Hadis seperti Ibn Shalah. Beberapa etika yang harus ada bagi seorang periwayat dalam menerima hadis ialah: Niat yang ikhlas, niat menjadi Syarat utama dalam menerima hadis, dalam perspektif etika, niat seorang muhaddits semata-mata hanyalah karena Allah, Kemudian etika selanjutnya ialah memiliki akhlak mulia, jujur dan tertolak riwayat perawi yang berdusta. Selanjutnya etika muhaddist dalam menerima ialah kesungguhan dalam menerima hadis,mengaplikasikan ilmu yang diperolehnya dan menghormati guru. Sedangkan etika dalam menyampaikan hadis ialah: Mampu mengajarkan hadis, Tidak menyampaikan hadis bila khawatir salah, Menghormati gurunya, sebagai salah satu bentuk penghormatannya ialah tidak menyampaikan hadis jika ada guru mereka di dalam majlis tersebut, kemudian membentuk sebuah halaqoh untuk meyampaikan hadis, seorang muhaddits tidak boleh menyembunyikan apa yang telah diperolehnya atau dipelajarinya.
STUDI NASKAH TERHADAP TEKS TENTANG KRITIK HADIS- HADIS IMAM MAHDI DALAM GRUP WHATSAPP KAJIAN : BELAJAR HADIS YUK
Authors: Alawiah Nela
Published: September 2022

This study aims to examine the text on the critique of the hadiths of Imam Mahdi presented in a study in a whatsapp group: Belajar Hadis Yuk. Studying hadith is a special study of hadith whose material is delivered virtually. The research method used is qualitative research. The data search technique in this study uses observation and documentation, the purpose of observation and documentation in this study is the delivery of material whatsapp group: Belajar Hadis Yuk entitled criticism of Imam Mahdi's hadiths. The data analysis technique of this research uses a  manuscript study of the text presented in the study of hadith learning. The results of this study indicate that: Hadith study on whatsapp group Belajar Hadis Yuk talk about the Criticism of Hadiths Imam Mahdi has provided insights on group members who do not study hadith in a special institution. The study can be accessed virtually via google meet discussing the critique of the hadiths of Imam Mahdi.
ARFI elastography for differentiating malignant and benign thyroid nodules
Authors: DEMİRPOLAT Gülen , TUNA Lale , KAVUKCU Gulgun , ERTAN Yeşim , PAKSOY Serpil , ÇEVİK Celalettin
Published: September 2022

Aim: To examine the diagnostic performance of virtual touch tissue quantification (VTQ) mode of Acoustic Radiation Force Impulse (ARFI) elastography imaging in differentiating benign and malignant thyroid nodules.
Materials and Methods: Two hundred four solid and mostly solid nodules >5mm were prospectively evaluated with ultrasonography, VTQ mode of ARFI elastography, fine needle aspiration biopsy, and when indicated with tissue pathology. Three shear-wave velocities (SWV) measurements were done in 196 nodules. The SWV ratio for each nodule was calculated as the mean value of the SWV of the nodule divided by the mean value of the adjacent parenchyma. The diagnostic performance of SWV value and SWV-ratio were assessed by a receiver-operating characteristic (ROC) curve analysis.
Results: The mean SWV value in the normal parenchyma, in benign and malign thyroid nodules, were 2.13±0.44 m/s, 2.06±0.80 m/s, and 2.06±0.88 m/s respectively. The SWV-ratios were 0.97±0.37 for benign thyroid nodules and 1.02±0.40 for malignant thyroid nodules. There was no significant difference between benign and malign nodules in terms of mean SWV values (t=0.008) (P=0.994) or SWV-ratios (t =0.596; P=0.527). No cut-off point was found to predict malignancy. In subgroup analysis, AUCs for the SWV and SWV-ratio were significantly different between nodules ˂10 mm and those ≥10 mm, but not with any other two groups (all P>0.05) (Table-2). The cutoff points for the differential diagnosis were 2.59 m/s for SWV and 1.0 for SWV- ratio respectively for nodules <10 mm.
Conclusion: VTQ mode of ARFI imaging does not have a good diagnostic performance for detecting malignancy and cannot contribute to reducing unnecessary thyroid biopsies.
Editorial
Authors: Briggs Daniel , Raymen Thomas
Published: September 2022

This editorial introduces readers to the most recent issue of JCCHE.
Avantages et bénéfices socio-économiques tirés par les ménages riverains de la Réserve de biosphère transfrontalière W du Bénin (RBTWB)
Authors: EL-HADJ ISSA Azizou , GBEDOMON Rodrigue Castro , GBEMAVO Dossou Sèblodo Judes Charlemagne , MENSAH Guy Apollinaire , SALAKO Valère Kolawolé , SINSIN Brice
Published: September 2022

L’étude a exploré les bénéfices socio-économiques et les liens de dépendance ou de ressources entre la Réserve de biosphère transfrontalière W du Bénin (RBTWB) et ses populations riveraines sur la période de 2000 à 2017. L’approche méthodologique inclut une enquête d’opinion et de revenus auprès de 340 ménages riverains de la RBTWB. Les analyses statistiques incluent des régressions logistiques et une analyse de la covariance pour évaluer les liens entre les riverains et la RBTWB, et leurs variations dans le temps et dans l’espace, puis des régressions linéaires généralisées pour évaluer la contribution monétaire et non monétaire de la RBTWB aux revenus des ménages riverains. Les résultats ont révélé des liens de dépendance des ménages riverains vis-à-vis de la RBTWB, notamment pour les terres agricoles et de parcours (pâturages). Ces liens ont varié significativement en fonction de la position géographique (commune, distance) et sont restés parfois forts pour les ménages très éloignés de la RBTWB. La contribution de la RBTWB aux revenus annuels (de mai de l’année n – 1 à avril de l’année n) et aux cash-flows des ménages a décru avec le temps et n’était que de 3,02 % pour la campagne agricole 2016-2017. Par ailleurs, les résultats mettent en évidence le foncier (terres agricoles) et la transhumance (terres de parcours) comme étant les problématiques communes aux riverains quelle que soit leur position géographique. Dans ce contexte de régression des liens et de faibles incitations économiques, les riverains de la RBTWB peuvent dans le meilleur des cas être démotivés à contrer les menaces internes et externes à la conservation, et dans le pire devenir la menace à la conservation.
Plantations monospécifiques d'espèces exotiques, déserts biologiques ou îlots de diversité floristique ? Exemple de situations biotiques et abiotiques contrastées au Nord-Kivu en République démocratique du Congo
Authors: KASEKETE Désiré Katembo , KIMBULUMA Christien Kakule , BOURLAND Nils , DROUET Thomas , MAKANA Jean-Remy , VASOMBOLWA Kamabu , MATE Jean-Pierre
Published: September 2022

Si les plantations forestières font l’objet d’un intérêt croissant en Afrique centrale, leur sous-bois reste encore peu étudié. Afin d’évaluer le potentiel des plantations d’espèces exotiques à participer à la restauration du couvert végétal sur les terres anthropisées du Kivu (République démocratique du Congo), la diversité floristique du sous-bois a été caractérisée et comparée dans une sélection de plantations monospécifiques d’Eucalyptus saligna et de Grevillea robusta sur deux sites (Sake et Kirumba) aux conditions altitudinales et pédoclimatiques différentes. La variation de la composition floristique des relevés a ensuite été analysée suivant certains paramètres écologiques. Enfin, les espèces indicatrices des conditions altitudinales et pédoclimatiques de chaque site ont été identifiées. Les données récoltées en 2018 et en 2020 dans 12 plantations par la méthode de l’aire minimale ont révélé une forte hétérogénéité dans la composition floristique des sous-bois. Bien que dominés par des herbacés, ces sous-bois hébergeaient aussi certaines espèces ligneuses et lianescentes. La richesse spécifique ne différait pas significativement entre les sites ni entre les espèces d’arbres plantées. Cette richesse variait d’un relevé à l’autre suivant la latitude, le pH du sol et les concentrations en aluminium et magnésium biodisponibles. Treize espèces indicatrices des conditions altitudinales et pédoclimatiques des sites ont été repérées dont neuf pour Sake et quatre pour Kirumba. La répétition des inventaires avait accru l’effort d’échantillonnage même si l’aire minimale n’avait pas significativement changé sur deux ans. Cette étude a mis en relief la contribution des plantations d’espèces exotiques à la reconstitution du couvert végétal sur les sites potentiellement dégradés du Kivu et suggère des mesures de gestion adaptées aux propriétés physico-chimiques des sols. L’utilisation des espèces indicatrices des conditions pédoclimatiques des sites comme prédicteurs de productivité mérite d’être testée dans les plantations étudiées afin de vérifier si leur présence pourrait servir d’outil de sélection des stations à reboiser.
Histoire évolutive de l’arbre fruitier Dacryodes edulis : implications pour sa conservation et sa gestion durable
Authors: Rimlinger Aurore
Published: September 2022

Dans les écosystèmes forestiers tropicaux, les humains utilisent de longue date les espèces végétales utiles, sources de nourriture, de fibre, de combustible ou de médication. Parmi ces produits forestiers non ligneux, certains d'entre eux ont progressivement été mis en culture, posant des questions tant sur les impacts évolutifs des interactions entre plantes et hommes que sur la durabilité des modes de gestion actuels de ces ressources. C'est le cas pour le safoutier (Dacryodes edulis, Burseraceae), un arbre fruitier emblématique d'Afrique centrale.

Dans cette thèse, la dynamique de la diversité cultivée du safoutier est abordée via une approche interdisciplinaire alliant génétique des populations et ethnoécologie, afin de comprendre d’une part l’histoire évolutive de l’espèce sur le temps long, d’autre part les effets des changements contemporains de ses modes de culture. L’approche génétique centrée sur l'histoire évolutive du safoutier a permis d’identifier différents groupes génétiques sur son aire de distribution. Les patrons de distribution de l’ADN chloroplastique semblent résulter des événements de glaciation du Quaternaire plutôt que de la mise en culture de l'espèce. L’accent mis sur les savoirs des cultivateurs dans l’approche ethnoécologique met en lumière la nomenclature fine qu’ils mobilisent, et les préférences différentes qu’ils ont en fonction des usages du fruit : une bascule s'opère en faveur du critère de la taille du fruit chez ceux destinant leur production au marché urbain. Enfin, le croisement des deux approches a permis de mettre en valeur les effets des réseaux informels d'échanges de semences sur la distribution de la diversité génétique. Les semences utilisées pour planter des arbres en ville proviennent ainsi en majorité d'échanges sur de longues distances. En conséquence, des niveaux de diversité identiques, voire supérieurs, sont présents dans les aires urbaines par rapport au milieu rural.

Ensemble, ces résultats permettent de conclure qu'il existe une grande diversité de connaissances, de pratiques et d'usages autour du safoutier, qui n'engendrent pas, à ce stade, d'effets néfastes sur sa diversité intra-spécifique. Le safoutier se présente comme un modèle stratégique pour étudier l'effet des pratiques humaines sur la diversité génétique en Afrique centrale, de nombreuses questions de recherche demeurant quant à l'origine de sa mise en culture et de sa diffusion.
Perceptions locales de la dégradation des ressources naturelles du corridor forestier de la Boucle du Mouhoun au Burkina Faso
Authors: OUATTARA Brama , SANOU Lassina , KOALA Jonas , HIEN Mipro
Published: September 2022

L’étude s’intéresse aux perceptions de la dégradation des ressources naturelles et examine les facteurs qui influencent la volonté des populations locales à intégrer les bonnes pratiques qui atténuent l’utilisation des feux, de la pâture et des pesticides. Nous avons analysé les stratégies locales qui pourraient restaurer les ressources naturelles et permettre une gestion durable. Les données ont été collectées auprès de 300 ménages ruraux dans trente villages riverains du corridor forestier de la Boucle du Mouhoun au Burkina Faso. Les résultats montrent selon l’échelle catégorielle de type Likert que les populations locales sont conscientes de la dégradation des ressources naturelles et en connaissent les principales causes : variabilité climatique, érosion des sols, feux, dégradation de la qualité du sol, pâture incontrôlée, coupe de bois, utilisation de pesticides et tenure foncière. L’âge, le genre, le statut de résidence, la source de revenu, la taille de l'exploitation et la tenure foncière sont explicatives de la volonté des communautés riveraines à inverser la tendance à la dégradation du corridor forestier de la Boucle du Mouhoun. En outre, les populations suggèrent la plantation d’espèces désirées et adaptées aux conditions de site, la mise en place des ouvrages antiérosifs qui améliorent la fertilité des sols et l’aide au rétablissement du couvert végétal. Elles promettent l’utilisation de pesticides homologués et à faible dose, l’interdiction de pâture dans les aires protégées, la protection et la conservation des arbres dans les champs. Au terme de cette étude, il ressort que les déterminants à prendre en compte pour une gestion durable des ressources naturelles et l’inversion de la tendance à la dégradation sont la gestion des feux, la pâture modérée, l‘utilisation modérée des pesticides et la réduction des défriches. Dans la formulation des stratégies de lutte contre la dégradation des ressources naturelles à mettre en place, il sera impérieux à l’avenir de tenir compte des caractéristiques socio-économiques.
Has economic growth reduced poverty in Nigeria? A critical analysis of the last two decades
Authors: Olasode Tikristini , Eke Chukwuemeka , Olaleye Olalekan Oluwabunmi
Published: September 2022

Purpose — This paper aims to examine how Nigeria's economic growth over the past two decades has contributed to poverty reduction.Method — This study adopted the desktop research method of qualitative and quantitative data and used various sources, including academic journals, publications, books, articles, and reports. The National Bureau of Statistics (NBS) of Nigeria, the United Nations Development Programme (UNDP), the Human Development Report, the World Bank Indicators, and the Central Bank of Nigeria (CBN) Statistical Bulletin are all places where secondary statistical data comes from.Result — Nigerian economy has experienced significant growth over the last two decades, but poverty rates in the country remain high. We also discovered that the Nigerian economy's high level of inequality, corruption, jobless growth, and monocity are some issues that have hindered the translation of economic growth into significant poverty reduction.Recommendation — Based on the analysis of this research and the peculiarity of the Nigerian economy, this paper recommends that diversification of the economy, investment in public services, and policies that encourage pro-poor growth are effective strategies that would lead to more significant poverty reduction. In addition, there is a need to study the nature of inequality in Nigeria. An in-depth study needs to be done on income inequality and the multidimensional forms of inequality prevalent in the country.Contribution — Research on economic growth and poverty in Nigeria mostly concentrated on the relationship between these variables. Only a few studies have investigated why the poverty rate continues to rise amid economic growth. This study tries to fill this gap and contribute empirically to the current literature on economic growth and poverty in Nigeria by studying the economic situations and factors surrounding the country's rising poverty rate.
Um exilado entre os Kaingang: a trajetória de Bartomeu Melià S. J. no Rio Grande do Sul
Authors: Brighenti Clovis Antonio
Published: September 2022

O presente artigo tem por objetivo analisar o período em que o Pe. Bartomeu Melià S.J. morou no Rio Grande do Sul, em Miraguaí, cidade limite com a Terra Indígena Guarita, pertencente ao povo Kaingang com presença de uma comunidade Guarani. Durante oito anos Melià atuou na coordenação da Pastoral Indígena do Interdiocesano Norte, organização composta pelas dioceses de Frederico Westphalen, Erechim, Passo Fundo e Vacaria, as quais tinham em suas circunscrições eclesiásticas presença dos povos Kaingang, em sua grande maioria, e um número menor de Guarani. Para analisar a presença de Pe. Melià, percorreremos suas publicações e ações realizadas no período, tanto no Interdiocesano como nas atividades acadêmicas desenvolvidas na Fundames e Unisinos. Também inquiriremos, sem intenção de elucidar, os motivos que levaram a transferência de Melià para essa região e sua pronta saída assim que as condições no Paraguai, de onde fora expulso, se tornaram favoráveis. Concluímos que esse foi, de fato, o exílio de Melià, o momento mais difícil de sua trajetória pastoral.
deslocamentos guarani: revisitando as fontes documentais com Bartomeu Melià
Authors: Mendes Júnior Rafael Fernandes , Pissolato Elizabeth
Published: September 2022

Neste artigo revisitamos um tema que atravessa a etnologia guarani desde o trabalho inaugural de Nimuendaju: aquele dos movimentos territoriais guarani que foram frequentemente interpretados enquanto busca da terra sem mal. O texto perpassa, sem pretensão de uma revisão sistemática, textos clássicos e suas abordagens da religião e das migrações guarani ou tupi-guarani, buscando pôr em questão hipóteses como a da busca religiosa (seja profética ou ascética) como motivação única e constante para as migrações guarani ou tupi-guarani ao longo de  cinco séculos; a da anterioridade à Conquista das migrações e do motivo mítico-religioso, o que  atestaria uma originalidade da cultura/religião nativas; a da cultura como experiência cuja "autenticidade" dependeria de manter-se igual a si mesma integralmente ou pela permanência de uma espécie de núcleo duro.  Na crítica a estas hipóteses, o artigo visa particularmente apontar limites da etnologia quando esta não se torna capaz de uma crítica das fontes históricas documentais, construindo interpretações na base de generalizações descuidadas ou afirmação de posições ideológicas. Buscando seguir a trilha indicada por Bartomeu Melià acerca de uma necessária garimpagem “arqueológica” das fontes documentais para a compreensão adequada de contextos vividos por grupos guarani coloniais, apresentamos um exercício analítico sobre um contexto de deslocamentos guarani na primeira metade do século XVII. A análise de cartas jesuíticas do período não deixa dúvidas sobre os deslocamentos ocorridos nas regiões do Guairá e Tapé em busca de proteção contra os ataques de bandeirantes paulistas, afastando-nos da tese do motivo mítico-profético como tema central das andanças guarani. Nossa expectativa é que este exercício venha contribuir para o desenvolvimento de uma etnologia guarani disposta a refletir com a história e sob a crítica das fontes documentais.
“Não existe uma língua que é mais antiga, que é mais importante do que o Guarani”
Authors: Tupã Alves Teodoro
Published: September 2022

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Liver transplantation for hepatoblastoma
Authors: Varvoglis Dimitrios N. , Ziogas Ioannis A. , Tsoulfas Georgios
Published: September 2022

Liver transplantation is the only potentially curative option for unresectable hepatoblastoma. The introduction of platinum-based chemotherapy drastically improved the survival outcomes of patients with hepatoblastoma. However, the use of neoadjuvant chemotherapy and the optimal number of cycles required in patients listed for liver transplantation, as well as the potential use of adjuvant chemotherapy, remain unclear. Additionally, the shortage of donor liver grafts, along with the lack of clear consensus on the management of metastatic hepatoblastoma, makes the decision on whether to proceed to liver transplantation even more complex and challenging. Technological advances may optimize intraoperative imaging of both the primary tumor and metastatic sites, thus facilitating complete resection. Such improvements, along with the wider use of social media platforms to increase public awareness, could potentially pave the way for more optimal implementation of liver transplantation for the treatment of patients with unresectable hepatoblastoma.
DESENVOLVIMENTO SUSTENTÁVEL A TÍTULO DAS COMUNIDADES TRADICIONAIS E DOS POVOS INDÍGENAS DO PANTANAL
Authors: Campello Livia Gaigher Bósio , Fernandes Thaís Fajardo Nogueira Uchôa
Published: September 2022

O presente artigo analisa o desenvolvimento sustentável a título das comunidades tradicionais e dos povos indígenas do Pantanal, por meio de convenções internacionais, da Constituição Federal de 1988 e de relatórios especiais da ONU. Questiona-se quais são os princípios internacionais e nacionais, na época do antropoceno, que fundamentam o desenvolvimento sustentável das comunidades tradicionais e dos povos indígenas do Pantanal. Com efeito, este trabalho tem como objetivo analisar a construção do direito ao desenvolvimento sustentável ao longo do tempo, a importância das comunidades tradicionais e povos indígenas para o desenvolvimento sustentável local e os princípios que fundamentam o desenvolvimento sustentável desses povos e comunidades do Pantanal. Neste estudo, utiliza-se a pesquisa descritiva e exploratória, bibliográfica e documental; orienta-se pelo método dedutivo.
Effect of Peptide Length on in Vitro and in Vivo Properties of 177Lu-labeled Peptide Analogs Targeting CCK2R
Authors: Hörmann Anton Amadeus , Klingler Maximilian , Rangger Christine , Mair Christian , Joosten Lieke , Franssen Gerben M. , Laverman Peter , von Guggenberg Elisabeth
Published: September 2022

Minigastrin (MG) analogs for therapy of CCK2R-expressing malignancies are limited by low stability in vivo or excessive accumulation in non-target organs. By modifying the C-terminal receptor-binding sequence, metabolization could be prevented and tumor targeting significantly improved. In this work, N-terminal changes of the peptide length were evaluated. Based on the amino acid sequence of DOTA-MGS5 (DOTA-DGlu-Ala-Tyr-Gly-Trp-(N-Me)Nle-Asp-1Nal-NH2), two new MG analogs were synthesized, by either introduction of a penta-DGlu moiety or depletion of the four N-terminal amino acids and introduction of a non-charged hydrophilic linker. Two CCK2R-expressing cell lines were used to demonstrate receptor interaction. Stability of the 177Lu-labeled peptide analogs was evaluated in human serum up to 24 h after incubation and in BALB/c mice up to 30 min after injection. The biodistribution profile and tumor targeting potential was evaluated in xenografted BALB/c nude mice. For both new MG analogs, the combination of strong receptor-specific cell interaction, high stability and enhanced tumor targeting could be demonstrated. Shortening of the peptide sequence lowered the absorption in the dose-limiting organs, whereas elongation increased uptake in renal tissue.
A Systematic Review and Quality Evaluation of Studies on Long-Term Sequelae of COVID-19
Authors: Vásconez González Jorge , Izquiero-Condoy Juan S. , Fernandez-Naranjo Raul , Ortiz-Prado Esteban
Published: September 2022

Background: COVID-19 made its debut as a pandemic in 2020; since then, more than 607 million cases and at least 6.5 million deaths have been reported worldwide. While the burden of disease has been described, the long-term effects or chronic sequelae are still being described. Objective: To describe the findings of a current systematic review of the long-term effects related to post-COVID-19 sequelae. Design: A systematic review was carried out in which cohort studies, case series, clinical case reports were included, and the PubMed, Scielo, SCOPUS and Web of Science databases were ex-tracted. Information published 2020 to June 1, 2022, was sought. Results: We reviewed 300 manuscripts during the first step of the literature review process. Then 260 abstracts were analyzed. In the end, we included 32 manuscripts: 9 for pulmonary, 6 for cardiac, 2 for renal, 9 for neurological and psychiatric, and 8 for cutaneous sequelae. Conclusion: Studies show that the most common sequelae are those linked to the lungs, followed by skin, cutaneous and psychiatric alterations. Women report a higher incidence of the sequelae, as well as those with comorbidities and severer COVID-19 history. The COVID-19 pandemic has not only caused death and disease since its apparition but has also sickened millions of people around the globe who potentially suffer from serious illnesses that will continue to add to the list of health problems and further burden healthcare systems around the world.
Mind the Gap – Deciphering GPCR Pharmacology Using 3D Pharmacophores and Artificial Intelligence
Authors: Noonan Theresa Clare , Denzinger Katrin , Talagayev Valerij , Chen Yu , Puls Kristina , Wolf Clemens Alexander , Liu Sijie , Nguyen Trung Ngoc , Wolber Gerhard
Published: September 2022

G protein-coupled receptors (GPCRs) are amongst the most pharmaceutically relevant and well-studied protein targets, yet unanswered questions in the field leave significant gaps in our understanding of their nuanced structure and function. 3D pharmacophore models are powerful computational tools in silico drug discovery, presenting myriad opportunities for the integration of GPCR structural biology and cheminformatics. This review highlights success stories in the application of 3D pharmacophore modeling to de novo drug design, discovery of biased and allosteric ligands, scaffold hopping, QSAR analysis, hit-to-lead optimization, GPCR de-orphanization, mechanistic understanding of GPCR pharmacology and elucidation of ligand-receptor interactions. Furthermore, advances in the incorporation of dynamics and machine learning will be highlighted. The review will analyze challenges in the field of GPCR drug discovery, detailing how 3D pharmacophore modeling can be used to address them. Finally, we will present opportunities afforded by 3D pharmacophore modeling in the advancement of our understanding and targeting of GPCRs.
Long Non-coding RNAs, Extracellular Vesicles and Inflammation in Alzheimer’s Disease
Authors: Canseco-Rodriguez Ania , Masola Valeria , Aliperti Vicenza , Meseguer-Beltran Maria , Donizetti Aldo , Sanchez-Perez Ana María
Published: September 2022

Alzheimer´s Disease (AD) has currently no effective treatment; however, preventive measures can significantly delay the progress/onset of the disease. Thus, accurate and early prediction of risk is an important strategy to alleviate the AD burden. Neuroinflammation is a major factor prompting the onset of the disease. Inflammation exerts its toxic effect via multiple mechanisms. Amongst others, it is affecting gene expression via modulation of non-coding RNAs (ncRNAs), such as miRNAs. Recent evidence supports that inflammation can also affect long non-coding RNAs (lncRNAs) expression. While the association between miRNAs and inflammation in AD has been extensively studied, the role of lncRNAs in neurodegenerative diseases has been less explored. In this review, we focus on lncRNAs and inflammation in the context of AD. Furthermore, since plasma-isolated extracellular vesicles (EVs) are increasingly recognized as an effective monitoring strategy of brain pathologies, we have focused on the studies reporting dysregulated lncRNAs in EVs isolated from AD patients and controls. The revised literature shows a positive association between pro-inflammatory lncRNAs and AD. However, the reports evaluating lncRNAs alterations in EVs isolated from plasma of patients and controls, although still limited confirm the value of specific lncRNAs associated with AD as reliable biomarkers. This is an emerging field that will open new avenues to improve risk prediction, patients’ stratification and may lead to the discovery of potential novel therapeutic targets for AD
Health Impact Assessment of Air Pollution Under a Climate Change Scenario: Methodology and Case Study Application
Authors: Coelho Sílvia , Ferreira Joana , Carvalho David , Lopes Myriam
Published: September 2022

The World Health Organization estimates that every year air pollution kills seven million people worldwide. As it is expected that climate change will affect future air quality patterns, the full understanding of the links between air pollution and climate change, and how they affect human health, are challenges of future research. In this scope, a methodology to assess the air quality impacts on health was developed. The WRF-CAMx modelling framework was applied for the medium-term future climate (considering the SSP24.5 scenario) and for the recent past (considered as baseline). Following the WHO recommendations, mortality health indicators were used to estimate health impacts of long-term exposures. For that, the Aveiro Region, in Portugal, was considered as a case study. Future climate results indicate the occurrence of higher temperatures, and lower total precipitation. Despite that, improvements in the main pollutants’ concentrations, and consequently in the reduction of the related premature deaths are foreseen, mainly due to the reduction of pollutants emissions imposed by the European legislation for the upcoming years. The applied approach constitutes an added value in this research field, being crucial to anticipate the effects of climate change on air quality and evaluate their impacts on human health.
Green and Healthy —Age Effects in Use and Perception of Urban Green Spaces and their Impact on Personal Health and Well-being during COVID-19 Pandemic
Authors: Taczanowska Karolina , Tansil Donna , Wilfer Jacqueline , Jiricka-Pürrer Alexandra
Published: September 2022

The COVID-19 pandemic drew public attention back to the living conditions related to housing, access to green areas in close neighbourhood and nearby recreation. Several studies confirm that visiting green spaces improved the health and wellbeing in times of crisis. This representative study for the metropolitan area of Vienna, Austria’s capital, confirms the high relevance of contact with nature, particularly for citizens to cope with the negative consequences and perceived stress, anxiety, nervousness and many other negative symptoms experienced during the health crisis. It highlights the importance of nearby smaller but also medium to large scale green areas in cities for health and wellbeing of the population. Moreover, it specifically adds novel insights on age effects in use and perception of urban green spaces during COVID-19 pandemic. The online panel survey (n=1012) was conducted in summer 2021. In order to obtain a representative sample reflective of the population’s characteristics, a (stratified) random sample was selected by applying the quota method. The objective was to obtain a sample which represented gender, age and regional distribution of the population of the City of Vienna as well as the immediately surrounding local communities. Interestingly, particularly young people spent more time outside in green areas during the pandemic, discovered novel spaces for the first time and stated a high relevance of contact with nature for their wellbeing. Elderly people above sixty five, on the contrary, stayed more frequently at home. Significant differences are visible between the age groups also with regard to negative symptoms experienced in case of restricted access to green areas due to strict pandemic measures such as lockdowns and quarantine. All age groups, however, similarly acknowledged the importance of green areas for their physical, mental and emotional health in general during the pandemic.
Interaction Between Participation and Impact of a Multicomponent Empowerment-based Psychosocial Mental Health Intervention on Service Users and Their Relatives
Authors: Eiroa-Orosa Francisco José , San Pío Maria Jesús , Marcet Gemma , Sibuet Isabela , Rojo Emilio
Published: September 2022

Relatives play an important role in mental health service users’ care. Interventions directed either at service users or their relatives may influence the other person as well. The project Activa’t per la salut mental (Get active for mental health) consisted of a series of four interventions addressed at people diagnosed with mental disorders and their relatives to help them in their recovery process, increasing their agency and quality of life. The objective of the present study is to evaluate the interaction of the participation of service users on their relatives’ outcomes and vice versa. The impact of the project was evaluated within an RCT. The treatment group had access to all the circuit interventions while the control group received treatment as usual and could only access one of the interventions. All participants were evaluated at baseline, six months, and twelve months after the end of the first intervention. Service users were evaluated with the Stages of recovery questionnaire, and relatives with the Family Burden Interview Schedule II and the Duke-UNC-11 questionnaires. The interaction between service users and their relatives was analysed by means of correlational analyses within the intervention group. Service users baseline characteristics influenced in the level of participation of relatives and vice versa. The results also indicated an interaction between service users’ recovery score changes on the change of care burden of relatives. Service users’ participation levels interacted with the decrease of relatives’ burden. These results can be extremely helpful in fostering interactive benefits in future projects addressing the wellbeing of mental health service users and their relatives. Future studies could use specific designs to explore the directionality of the causality of these effects.
Potential Inhibitors of EGFR Tyrosine Kinase from Scutellaria baicalensis: A Cheminformatics and Molecular Docking Studies
Authors: Yusuf Amina J. , Adegboyega Abayomi E. , Yakubu Abdulbasit H. , Johnson Grace I. , Asomadu Rita O. , Adeduro Mary N. , Chukwuma Ifeoma F. , Ugwah-Oguejiofor Chinenye J. , Okoh Olayinka S. , Alkhuriji Afrah F. , Al-Megrin Wafa Abdullah I. , Waard Michel De , Batiha Gaber El-Saber , Johnson Titilayo O.
Published: September 2022

Epidermal Growth Factor Receptor (EGFR) tyrosine kinase is a cell surface receptor whose overexpression has been associated with different types of cancers including brain cancer (glioblastoma multiforme). The ability of the extract of Scutellaria baicalensis to inhibit the proliferation of malignant glioma cells have been reported. Thus, in this study we report the identification of 307 bioactive constituents responsible for the anti-glioblastoma multiforme effect from S. baicalensis using in silico studies such as molecular docking, binding free energy calculations, pharmacophore modelling, induced-fit docking, gene enrichment analysis, molecular dynamic simulations and ADMET predictions. A total of 307 chemical constituents of S. baicalensis were screened and the top 10 scoring compounds indicated different binding affinities ranging from -9.010 to -6.427 kcal/mol towards the EGFR tyrosine kinase; Ganhuangenin, 5,7,2',5'-tetrahydroxyflavone, (2R)-2-(2,6-dihydroxyphenyl)-3,4-dihydro-2H-chromene-5,7-diol, and tenaxin I possess higher binding affinities (-9.010 to -8.649 kcal/mol) compared to the standard ligand, erlotinib having -8.539 kcal/mol. The compounds interacted with amino acids of clinical importance such as MET 769, GLU 738, THR 766 via H-bond. The structural features involved in the interaction with the target were mostly two aromatic rings, H-bond donors and acceptors and some hydrophobic interactions which varies between the ligands. Better docking scores in the induced-fit docking further validates the inhibitory potential of the compounds against the flexible protein. All the top-scoring ligands from S. baicalensis had zero Lipinski violation and also obeyed other drug-likeness rules by Ghose, Veber, Egan, and Muegge with the exception of breviscapine. Interestingly, all the compounds are not likely to be hepatotoxic, mutagenic, or cytogenic, making them potentially safe as anti-cancer agents.
Lifeguard Training Program and Drowning Death Rates in Ecuador, 2000–2019
Authors: Rojas Tatiana , Dunning Paul , Sisa Ivan
Published: September 2022

Drowning is a common cause of death and disability worldwide. We report the experience of Ecuador, a middle-income country, where a lifeguard training program was implemented to reduce incidents of drowning. We describe how “Project Ecuador” was able to expand from one to 20 beaches in a five-year period. We detail how these interventions triggered the creation of a self-sustained national program and a law proposal that guarantee a safe environment across the Ecuadorian coastal region. (Am J Public Health. 2022;112(11):1546–1550. https://doi.org/10.2105/AJPH.2022.307013 )
Humor and identity in the performance of a stand-up comedian with disability
Authors: Tan Nirel Angwen Wisley , Wijaya Mike Pratiwi , Setyaningsih Nina
Published: September 2022

Being a stand-up comedian with medical issue requires the ability to apply certain techniques to create humor when performing stand-up comedy. Josh Blue (JB) is one of those well-known stand-up comedians diagnosed with cerebral palsy. This study aims to investigate the linguistics aspects applied by JB in delivering his jokes and how these aspects relate to identity JB wants to present. This research employed a qualitative descriptive method to analyze the data. The results reveal that JB uses irony in his stand-up comedy. In terms of linguistic features, JB mostly applies silent pause, while in joke technique JB applies self-ridicule. These findings suggest that the linguistics aspects used by JB present that disability can be a special identity that affects people’s perception and their ways of interaction with other people. JB linked each of his experience of being disabled by wrapping it well as his joke technique. JB has privilege in processing his disability into a primacy in joke technique without sounding condescending and even sarcastic.
Analisis Kualitas Buah Merah Kopi Arabika Gayo dan Korelasinya dengan Kualitas Biji pada Ketinggian Berbeda
Authors: Abubakar Yusya' , Hasni Dian , Wati Siti Agustina
Published: September 2022

Kualitas biji dan citarasa kopi Arabika Gayo dipengaruhi oleh ketinggian tempat tumbuh dan kondisi kematangan buah. Kematangan buah kopi yang dipanen sering bercampur dan dikhawatirkan akan memengaruhi mutu dan citarasa kopi. Penelitian bertujuan untuk mengetahui kualitas buah kopi Arabika yang berasal dari ketinggian tempat yang berbeda dengan kualitas kopi beras dan seduhannya. Penelitian dilaksanakan di Kabupaten Aceh Tengah, bulan April-Juni 2021. Penelitian dilakukan melalui wawancara kepada petani dan pengepul, serta mengamati kualitas buah merah, mutu fisik, dan mutu seduhan (SCAA) kopi yang berasal dari tiga ketinggian tempat yang berbeda, yaitu 1000-1200 m dpl (E1), 1201-1400 m dpl (E2), dan 1401-1600 m dpl (E3).  Penelitian dirancang berdasarkan Rancangan Acak Kelompok nonfaktorial. Hasil penelitian menunjukkan bahwa ketinggian tempat tumbuh berpengaruh terhadap kualitas buah yang dipanen. Semakin tinggi tempat tumbuh maka semakin menurun persentase buah rusak dan semakin tinggi kualitas kopi berasnya. Hasil cupping test menunjukkan kualitas kopi termasuk specialty dengan skor rata-rata 82,67 + 0,98. Kopi dari lokasi yang lebih tinggi mempunyai skor atribut fragrance, flavor, dan acidity yang lebih tinggi. Analisis korelasi menunjukkan adanya korelasi positif kuat antara persentase buah kopi rusak dengan nilai cacat kopi beras, korelasi positif moderat antara persentase buah mengapung dengan nilai cacat kopi beras dan korelasi positif lemah antara persentase buah hijau dengan skor total cup test. Hasil penelitian mengidikasikan perlunya meningkatkan pemahaman kepada petani untuk hanya memanen kopi Arabika yang sudah berwarna merah.