bluuebunny/crossref_metadata_2025 huggingface dataset:
Computed Tomography Confirms Increased Left Atrial Volume in Patients with Bayés Syndrome Referred for Catheter Ablation of Atrial Fibrillation
Authors: Cismaru Gabriel , Wagner Gwendolyn , Gusetu Gabriel , Minciuna Ioan-Alexandru , Irimie Diana , Fringu Florina , Tomoaia Raluca , Comsa Horatiu , Caloian Bogdan , Pop Dana , Rosu Radu Ovidiu
Published: October 2024

Background: Bayés syndrome is a recently identified condition that is defined by the presence of an interatrial block on a surface electrocardiogram, in addition to atrial arrhythmias such as atrial fibrillation, tachycardia, or left atrial flutter. This syndrome is linked to an increased risk of stroke, morbidity, and mortality. An interatrial block is a conduction delay between the right atrium and left atrium and can be recognized by a P wave duration >120 ms. It is known that P wave duration can estimate the size of the left atrium measured via echocardiography, which is a marker for stratifying cardiovascular risk. Our study aims to verify whether the duration of the P wave can estimate the volume of the left atrium measured by computed tomography in patients with an interatrial block. Methods: We included 105 patients with a sinus rhythm and a partial or advanced interatrial block (IAB) who underwent contrast-enhanced cardiac computed tomography (CT). The mean age was 62.2 ± 10.1 years, and 38% of the patients were women. Results: The mean P wave duration was 122.6 ± 11.4 ms in the partial IAB group and 150 ± 8.4 ms in the advanced IAB group (p < 0.01). The mean left atrial volume was 115 ± 39 mL in the partial IAB group and 142 ± 34 mL in the advanced IAB group (p = 0.001). P wave duration was longer in patients with an advanced as opposed to partial interatrial block. Left atrial volume and LAVI were higher in patients with an advanced as opposed to partial interatrial block. Conclusions: All the patients (100%) with an advanced IAB had a dilated left atrium. P wave duration can accurately estimate LA volume in patients with an IAB using the formula: LA volume = 0.6 × P wave + 46 mL.
Artificial Intelligence (AI)-Based Radar Signal Processing and Radar Imaging
Authors: Feng Weike , Hu Xiaowei , He Xingyu
Published: October 2024

In recent years, artificial intelligence (AI), especially deep learning, has led to remarkable achievements in image recognition, speech recognition, autonomous driving and many other fields [...]
A Study on Ways to Expand the Speed Operation Range of Dental Laboratory Handpiece Motors Using Low-Cost Hall Sensors
Authors: Park Gwangmin , Lim Jong Suk
Published: October 2024

In the dental prosthetics field, BLDC micro-motors are primarily used for implant procedures. As dental materials become increasingly harder, there is a growing demand for higher performance motors to precisely process these materials. However, difficulties in motor development arise due to price competitiveness. Dental motors require capabilities such as low-speed, high-torque for drilling operations and high-speed rotation for precise machining of high-strength dental materials. Additionally, there is a requirement to address thermal issues to prevent user burns due to motor-generated heat. Typically, motors requiring precision control utilize high-resolution position sensors like encoders or resolvers to acquire and control the rotor’s position. However, the high cost of these sensors and constraints such as increased device size pose challenges in maintaining price competitiveness. In this paper, we propose a control algorithm that satisfies the requirements for low-speed, high-torque and high-speed operation requirements for precision machining without hardware modifications using a BLDC micro-motor equipped with an inexpensive Hall sensor commonly used in the dental field. Furthermore, the algorithm is designed to ensure stable operation even in the event of Hall sensor failure or malfunction, and its effectiveness is validated through experiments.
Modeling Population Mobility Flows: A Hybrid Approach Integrating a Gravity Model and Machine Learning
Authors: Liu Jingjing , Xu Lei , Ma Le , Chen Nengcheng
Published: October 2024

Population mobility between cities significantly affects traffic congestion, disease spread, and societal well-being. As globalization and urbanization accelerate, understanding the dynamics of population mobility becomes increasingly important. Traditional population migration models reveal the factors influencing migration, while machine learning methods provide effective tools for creating data-driven models to handle the nonlinear relationships between origin and destination characteristics and migration. To deepen the understanding of population mobility issues, this study presents GraviGBM, an expandable population mobility simulation model that combines the gravity model with machine learning, significantly enhancing simulation accuracy. By employing SHAPs (SHapley Additive exPlanations), we interpret the modeling results and explore the relationship between urban characteristics and population migration. Additionally, this study includes a case analysis of COVID-19, extending the model’s application during public health emergencies and evaluating the contribution of model variables in this context. The results show that GraviGBM performs exceptionally well in simulating inter-city population migration, with an RMSE of 4.28, far lower than the RMSE of the gravity model (45.32). This research indicates that distance emerged as the primary factor affecting mobility before the pandemic, with economic factors and population also playing significant roles. During the pandemic, distance remained dominant, but the significance of short distances gained importance. Pandemic-related indicators became prominent, while economics, population density, and transportation substantially lost their influence. A city-to-city flow analysis shows that when population sizes are comparable, economic factors prevail, but when economic profiles match, living conditions dictate migration. During the pandemic, residents from hard-hit areas moved to more distant cities, seeking normalcy. This research offers a comprehensive perspective on population mobility, yielding valuable insights for future urban planning, pandemic response, and decision-making processes.
Consequences of the Poor Anticoagulation Control of Patients with Non-Valvular Atrial Fibrillation Treated with Vitamin K Antagonists
Authors: Sicras Mainar Antoni , Salazar-Mendiguchía Joel , del Campo Alonso María Isabel , Echeto Ainara , Vilanova Larena David , Comín Colet Josep
Published: October 2024

Background: The prevention of thromboembolisms through anticoagulation and heart rate control is crucial in managing non-valvular atrial fibrillation (NVAF). This study aimed to analyze the consequences of poor anticoagulation control with vitamin K antagonists (VKAs) in Spanish patients with NVAF, focusing on thrombotic events, bleeding, mortality, healthcare resources (HRU), and costs. Methods: This observational, retrospective study used electronic medical records (BIG-PAC® database) of NVAF patients who started VKA treatment between 1 January 2016 and 31 December 2018. Patients were followed up for two years and classified by poor or adequate anticoagulation control. Demographic and clinical characteristics, treatments, incidence of cardiovascular events, mortality rates, HRU, and costs were analyzed. Results: Patients with poor control (n = 2136) had a 75% greater probability of suffering a cardiovascular event compared to patients with adequate control (n = 2351) (HR, 1.75 [95%CI: 1.43–2.14; p < 0.001]). Cardiovascular events, major bleeding, minor bleeding, systemic thromboembolism, and ischemic strokes were reduced by 32.1%, 46.2%, 29.6%, 22.2%, and 16.1%, respectively. It was estimated that adequate anticoagulant control saved EUR 455/patient with NAVF due to reduced hospitalization for cardiovascular events. Conclusions: For VKA-treated NVAF patients, poor anticoagulation control was associated with a higher number of cardiovascular events, greater consumption of HRU, and higher management costs than for patients with adequate control.
Comment on Wróblewska-Czajka et al. Outcomes of Boston Keratoprosthesis Type I Implantation in Poland: A Retrospective Study on 118 Patients. J. Clin. Med. 2024, 13, 975
Authors: Geoffrion Dominique , Harissi-Dagher Mona
Published: October 2024

We read with interest the article “Outcomes of Boston Keratoprosthesis Type I Implantation in Poland: A Retrospective Study on 118 Patients” by Wróblewska-Czajka et al [...]
Development, Evolution, and Outcomes of More Anatomical Reverse Shoulder Arthroplasty
Authors: Sanchez-Urgelles Pablo , Kolakowski Logan , Levin Jay M. , Frankle Mark A.
Published: October 2024

Reverse shoulder arthroplasty (RSA) has become a widely used procedure since its introduction in the 1980s, and is currently used to treat a wider range of conditions than its original indication. The original Grammont-style RSA revolutionized shoulder arthroplasty but had several limitations, including scapular notching and reduced rotational motion. This review discusses the evolution of RSA design, particularly the development of a lateralized center of rotation constructs, which aims to improve all the disadvantages associated with the Grammont-style design and more closely reproduce the native anatomy in order to improve patient outcomes in an expanded context of pathologies.
Ethnic Disparities of Arrival Following ST Elevation Myocardial Infarction in South Israel
Authors: Zeldetz Vladimir , Nevzorov Roman , Weissberg Itai , Jotkowitz Alan B. , Shamia David , Slutsky Tzachi , Schwarzfuchs Dan
Published: October 2024

Background: Early activation of the emergency medical service (EMS) is crucial for the care of patients with STEMI. Methods: A retrospective cohort study of patients hospitalized with STEMI was conducted. Two groups of patients were compared: Bedouins and Jews. The primary outcome was one-year mortality. The secondary endpoints were 30-day mortality, mode of transportation and door-to-balloon time. Results: There were 445 Bedouin patients (BPs) and 1103 Jewish patients (JPs). BPs with STEMI were significantly younger than JPs, had more diabetes and higher rates of smoking. More JPs arrived at the hospital by ambulance compared to BPs (56.9% vs. 31.9%, p < 0.001). Direct transportation to the catheterization laboratory was observed in 51.9% of JPs and in 43.6% of BsP, p = 0.003. Door-to-balloon time was longer in BPs compared to JPs (median 65 min vs. 62 min, p = 0.044). There were no differences in one-year, 30-day and in-hospital mortality between the two groups. After adjustment by propensity score analysis for JPs vs. BPs, there was a protective factor for one-year mortality (hazard ratio (HR), 0.68; 95% CI 0.48–0.97), p = 0.034. Thirty-day and one-year mortality in the subgroup of BPs that arrived at the hospital from the outpatient clinic was higher compared to JPs (7.1% vs. 4.4%, p = 0.004 and 10.4% vs. 5.6%, p < 0.001, relatively) Conclusions: Underuse of EMS by BPs with STEMI compared to JPs resulted in a delay in direct transportation to the catheterization laboratory, longer door-to-balloon time and a higher 30-day and one-year mortality in the subgroup of BPs who arrived at the hospital after visiting an outpatient clinic.
Effect of Oral Bisphosphonates on Vertebral Fractures in Males Living with HIV: A Seven Year Study
Authors: Pezzaioli Letizia Chiara , Porcelli Teresa , Delbarba Andrea , Tiecco Giorgio , Castelli Francesco , Cappelli Carlo , Ferlin Alberto , Quiros-Roldan Eugenia
Published: October 2024

Background: Osteoporosis and vertebral fractures (VFs) are frequently observed in males living with HIV (MLWH). While bisphosphonates seem effective on bone mineral density (BMD) in MLWH, data on VFs are lacking. In this real-life longitudinal study performed on 118 MLWH (median age 53) who were followed-up for a median of 7 years, we aimed to evaluate the long-term efficacy of oral bisphosphonates on VFs in MLWH. Methods: The inclusion criteria were age >18, stable HIV infection, bisphosphonate-naïve, blood samples from the same laboratory, and three densitometries and morphometries performed with the same densitometer. Results: At baseline, VFs were detected in 29/118 patients (24.6%). Patients with VFs were older (p. 0.042), had longer HIV infection duration (p. 0.046) and antiretroviral exposure (p. 0.025), and demonstrated higher luteinizing hormone levels (LH, p. 0.044). Of the 29 patients with VFs at inclusion, 11 developed new VFs, of which 8 were under oral bisphosphonates (p. 0.018). Among the 89 without basal VFs, 11 developed VFs, of which 2 were under oral bisphosphonates. Patients with a worsened bone condition (regarding BMD and/or new VFs, n. 32) had more frequently high LH levels (>9.4 mIU/mL, p. 0.046) and higher HCV co-infection compared to patients with a stable bone condition (p. 0.045). It should be noted that 38.6% of patients discontinued oral bisphosphonates due to medical indication or personal choice, and 14.0% never started them. Conclusions: In conclusion, we found that oral bisphosphonates were not completely effective in preventing VFs, especially in patients with VFs at baseline; this is probably due to the multifactorial pathogenesis of fragility fractures in this population. A poor adherence to treatment and attention to gonadal function are also important issues in this population.
Iris Fixation for Intraocular Lens Dislocation: Relocation with Iris Suture Versus Exchange to Sutureless Iris Claw IOL
Authors: Bellucci Carlo , Mora Paolo , Romano Alessandra , Tedesco Salvatore Antonio , Troisi Mario , Bellucci Roberto
Published: October 2024

Background/Objectives: To compare the clinical outcome of suture and sutureless iris fixation techniques for dislocated intraocular lenses (IOLs). Methods: Retrospective cohort study including patients who underwent surgery for late IOL dislocation over a 10-year period. IOL repositioning was achieved either by suturing the original IOL to the iris using the Siepser slipknot technique or by replacing it with a retropupillary sutureless iris claw IOL. Data collected during surgery included the type of dislocation, the need for anterior or posterior vitrectomy, duration of surgery, and intraoperative complications. Six months after surgery we assessed the eye and iris anatomy; refraction, astigmatism, and visual acuity; endothelial cell damage; and rate of postoperative complications. Results: Included in the study were 60 patients: 32 underwent IOL relocation and 28 underwent IOL exchange. Pseudoexfoliation (43.7% and 39.3%) and retinal surgery (34.4% and 28.6%) were identified as the main possible causes for IOL dislocation. The mean duration of the surgery was 62.9 ± 14.9 min for the Relocation group, and was 42.7 ± 11.4 min for the Exchange group (p < 0.001), with similar low intraoperative complication rates (6.25% and 7.14%, respectively). The studied parameters showed no differences between the two groups postoperatively, except for corneal astigmatism which was 1.31 ± 0.45 D in the Relocation group and was 1.89 ± 0.86 D in the Exchange group (p < 0.001). Conclusions: Both suture and sutureless iris fixation techniques for dislocated IOLs yielded similarly favorable outcomes in this study. IOL relocation resulted in less postoperative astigmatism, while IOL exchange offered the advantage of shorter surgical time.
Volumetric CT Assessment of In Situ Induced Hepatic Lesions in a Transgenic Swine Model
Authors: Smetanick Derek , Stolley Danielle , Fuentes David , Fowlkes Natalie W. , Shakoor Faith , Stenkamp Maria Sophia , Hicks Samantha , Parrish Steve , Cressman Erik
Published: October 2024

The growth rate of in situ-induced hepatic lesions in an Oncopig large animal model is quantitatively assessed. Oncopigs (n = 9) received baseline triple-phase CT scans prior to lesion induction. Lesions were subsequently induced by delivering the Ad-Cre vector to four locations in the liver. Triple-phase CT scans were obtained weekly to track the growth of the lesions. Animals were sacrificed at 14, 21, or 28 days (n = 3 in each group). The overall success rate of lesion generation was ~78%. Histopathology sections consistently revealed lesions that were highly inflammatory and consisted of a large leukocyte population without clear evidence of carcinomas. Lesions presented within imaging as hypovascular, low attenuating masses with slight contrast enhancement around the margins but little to no enhancement within the lesions themselves. The observed lesions were manually segmented on the venous phase image. Segmentation volumes were fitted to a logistic growth and decay model. Several lesions observed at earlier time points in the 28-day group had fully regressed by the time of the necropsy. The overall trend of rapid growth for the first 21 days, with spontaneous regression of the lesions being observed from day 21 to 28, suggests that the optimal window for experimental studies may be from days 14 to 21. The data and mathematical models generated from this study may be used for future computational models; however, the current model presented has moderate clinical relevance because many induced tumors resolved spontaneously within a few weeks. Awareness and careful consideration of the modest relevance and limitations of the model are advisable for each specific use case.
Criteria for Assessing Exposure to Biomechanical Risk Factors: A Research-to-Practice Guide—Part 1: General Issues and Manual Material Handling
Authors: Graziosi Francesca , Bonfiglioli Roberta , Decataldo Francesco , Violante Francesco Saverio
Published: October 2024

Musculoskeletal disorders are the most prevalent occupational health problem all over the world and are often related to biomechanical risk factors; to control these risk factors, several assessment methods (mostly observational) have been proposed in the past 40 years. An in-depth knowledge of each method to evaluate biomechanical risk factors is needed to effectively employ them in the field, together with a robust understanding of their effective predictive value and limitations. In Part 1, some general issues relevant to biomechanical risk assessment are discussed, and the method for assessing manual material handling after receiving more robust validation data is reviewed (Revised NIOSH Lifting Equation), together with a discussion about variability of tasks. Similarly, for the assessment of the biomechanical exposure of the upper limb, the TLV for Hand activity (ACGIH®) is presented in Part 2 of this guide, together with criteria to proportion risk assessment to the working duration in part-time jobs.
Integrated Analysis of microRNAs and Transcription Factor Targets in Floral Transition of Pleioblastus pygmaeus
Authors: Yao Wenjing , Shen Peng , Yang Meng , Meng Qianyu , Zhou Rui , Li Long , Lin Shuyan
Published: October 2024

Bamboo plants have erratic flowering habits with a long vegetative growth and an uncertain flowering cycle. The process of floral transition has always been one of the hot and intriguing topics in bamboo developmental biology. As master modulators of gene expression at the post-transcriptional level, miRNAs play a crucial role in regulating reproductive growth, especially in floral transition of flowering plants. Pleioblastus pygmaeus is a kind of excellent ground cover ornamental bamboo species. In this study, we performed miRNA expression profiling of the shoot buds and flower buds from the bamboo species, to investigate flowering-related miRNAs in bamboo plants. A total of 179 mature miRNAs were identified from P. pygmaeus, including 120 known miRNAs and 59 novel miRNAs, of which 96 (61 known miRNAs and 35 novel miRNAs) were differentially expressed in the shoots at different growth stages. Based on target gene (TG) prediction, a total of 2099 transcription factors (TFs) were annotated to be TGs of the 96 differentially expressed miRNAs (DEMs), corresponding to 839 recordings of DEM-TF pairs. In addition, we identified 23 known DEMs involved in flowering and six known miRNAs related to floral organ development based on previous reports. Among these, there were 11 significantly differentially expressed miRNAs, with 124 TF targets corresponding to 132 DEM-TF pairs in P. pygmaeus. In particular, we focused on the identification of miR156a-SPL (SQUAMOSA Promoter-Binding protein-Like) modules in the age pathway, which are well-known to regulate the vegetative-to-reproductive phase transition in flowering plants. A total of 36 TF targets of miR156a were identified, among which there were 11 SPLs. The Dual-Luciferase transient expression assay indicated miR156a mediated the repression of the PpSPL targets in P. pygmaeus. The integrated analysis of miRNAs and TGs at genome scale in this study provides insight into the essential roles of individual miRNAs in modulating flowering transition through regulating TF targets in bamboo plants.
Anticonvulsant, Anticholinesterase and Cytoprotective Effects of the Aqueous Extract of Lippia sidoides Cham
Authors: Camilo Cicera Janaine , Leite Débora Odília Duarte , de Carvalho Natália Kelly Gomes , Castro José Walber Gonçalves , de Menezes Jane Eire Silva Alencar , dos Santos Helcio Silva , Silva Joanda Paolla Raimundo , Alves Daniela Ribeiro , de Morais Selene Maia , Rodrigues Fabíola Fernandes Galvão , da Costa José Galberto Martins
Published: October 2024

(1) Background: Lippia sidoides Cham is a Brazilian aromatic plant rich in phenolic compounds. In traditional medicine, its leaves are used to treat diseases of the Central Nervous System such as stress and anxiety. This study evaluates the capacity of the aqueous extract of L. sidoides as an anticonvulsant, anticholinesterase and antihemolytic agent. (2) Methods: The extract was obtained from the leaves using water as a solvent, then dried in a spray dryer. The anticonvulsant effect was evaluated in zebrafish models using the pentylenetetrazol (PTZ) method. The anticholinesterase effect was determined using the acetylcholinesterase enzyme and physostigmine as a positive control. The antihemolytic action was evaluated by exposing erythrocytes to different concentrations of NaCl in the presence and absence of the extract. (3) Results: The anticonvulsant effect was observed at a concentration of 400 mg/kg, delaying convulsive crises. In the anticholinesterase assay, a dose-dependent action and variation in the effect over time were observed, demonstrating a reversible effect of the extract. For the osmotic fragility test, the extract showed satisfactory results, providing cellular protection across all variations of NaCl concentration. (4) Conclusions: These results demonstrate the promising potential of L. sidoides extract for the development of drugs that act in the treatment of diseases that affect the Central Nervous System.
The Responsibilities of Social Work for Ecosocial Justice
Authors: Parra Ramajo Belén , Prat Bau Núria
Published: October 2024

The crisis of civilization we are experiencing unbalances the inter-relational, interdependency and intergenerational relationships of the planetary ecosystem, putting all species at risk. The current relationship between the unlimited economic development model and its social impacts in all regions, territories and communities is analyzed. These are more severe in the global South and the most impoverished populations, which often leads to conflicts, the deterioration of subsystems of life, and, as a result, movements of people. These challenges highlight the close interrelationship between social justice and issues of ecological injustice acting as a new source of inequality. The responsibility of social work, which is called on to incorporate the ecosocial perspective in all its areas and dimensions of practice, is becoming consolidated. To achieve this, five measures are proposed: expanding and strengthening the ethical and political basis of the profession; promoting the skilling-emancipatory models; cutting across all levels, methodologies and action areas; new fields of practice for ecosocial work; and introduction into social work curriculums. Social justice cannot be fully achieved without taking ecological justice into account.
Applications of 3D printing and digital transformation in aerospace engineering and telecommunication technologies
Authors: Ivanova Yoana
Published: October 2024

The aim of the development is to present the overall process of building functional prototypes for the purposes of aerospace engineering and telecommunication technologies, based on specific examples from the author's scientific and practical work. The scientific-applied contribution of the research is expressed in the correct selection and comparative analysis of compatible software products and devices for 3D modeling, digital transformation and 3D printing of objects from the space infrastructure and. in particular, of radio technical devices as key components of telecommunication satellites. The presented practical results are in the form of a final product that, if the criteria for precise modeling and the selection of a suitable material for 3D printing are met, can satisfy the quality criteria of the relevant industry for which it is intended.
Deterministic networks using segment routing
Authors: Simeonova Tsvetelina
Published: October 2024

The aim of the work is to analyze the new direction in telecommunications - creation of deterministic networks using segment routing technology within IPv6. The results obtained cover the consideration of network functions in a deterministic IP network (DIP), its architecture and principle of operation. The various aspects of segment routing (SR) technology are given, as well as the many use cases, incl. traffic engineering, network failure recovery, stateless chaining of services, introduction of 5G network "slices", cross-domain switching to connect users to applications on servers in multiple data centers, segment routing in SD-WAN. The main technologies of a DIP network are considered: traffic flow shaping (smoothing), input scheduling, time slot scheduling. The contributions relate to analysis and conclusions on the applicability, scope and development of DIP networks using segment routing technology within IPv6.
Interaction between the 4G - EPC core and the 5G RAN
Authors: Pasarelski Rosen , Angelov Krasen
Published: October 2024

The Radio Access Network - 5G RAN is designed to work seamlessly with the existing 4G EPC network infrastructure. This enables a smooth transition from fourth 4G to fifth generation 5G mobile systems, both for operators and end users. The radio access network - 5G RAN uses a new core network architecture - 5GC, which is designed to be more flexible and scalable than the previous EPC architecture.
The purpose of writing the article is to analyze the methods of interaction between the EPC core of 4G networks and the 5G system core. To explore interfaces and interconnection protocols with an emphasis on roaming and non-roaming architectural models. To discuss the interaction between the 5GC core network and the E-UTRAN radio network associated with the EPC in terms of achieving this goal through non-3GPP access.
Analysis of the methods of interaction between the EPC core of 4G networks and the 5GС, the study of interfaces and interaction protocols in different operating environments can be noted as contributions to the development of the article.
Nomenclatural Updates in Anomospermum (Anomospermeae: Menispermaceae)
Authors: Ortiz Rosa del C.
Published: October 2024

Two new combinations, Anomospermum prancei (Barneby & Krukoff) R. Ortiz and A. verruculosum (Krukoff & Barneby) R. Ortiz, are made in the Neotropical genus Anomospermum Miers (Anomospermeae–Menispermaceae) to conform with the newly revised classification based on morphology and DNA sequence data.
THE REPORT ON THE KAZAKHSTAN DELEGATION PARTICIPATION IN THAILAND TRAINING COURSE FOR CONCERNED OFFICIALS ON DRUG TREATMENT AND REHABILITATION
Authors: M.V. Prilutskaya
Published: October 2024

The article presents a report on the participation of the Kazakhstan delegation in the training course for concerned officials on Drug Treatment and Rehabilitation in the period of 24-31 August, 2015 (Thailand). The role of Conference on Interaction and Confidence Building Measures in Asia was introduced in part of activity aimed to drug abuse combating as well as treatment and rehabilitation. The goals and objectives of the training course were emphasized. The article notices the work principles for 24 member states. The results of the training course were reflected in the form of the 5 recommendatory principles.

В статье приведен отчет об участии казахстанской делегации в учебном курсе по лечению и реабилитации наркозависимых для заинтересованных официальных лиц, прошедший с 24 по 31 августа 2015 года в Таиланде. Подчеркнута роль работы Секретариата Совещания по Взаимодействию и мерам доверия в Азии по внедрению мероприятий, направленных на противодействие наркомании, в том числе в сфере лечения и реабилитации зависимостей. Освещены основные цели и задачи обучающего курса. Упомянуты принципы работы делегаций из 24 стран-участниц. Результаты тренинга отражены в форме 5 рекомендательных принципов.

Мақалада2015 жылдың24-31 тамызы аралығында Тайландта қазақстандық делегацияның нашақорлыққа тәуелділерді емдеу және сауықтыру бойынша мүдделі ресми тұлғаларға арналған оқыту курстарына қатысуы туралы есеп берілген. Азияда нашақорлыққа қарсы әрекеттерге бағытталған, оның ішінде тәуелділіктерді емдеу және сауықтыру аясындағы шараларды енгізу жөніндегі Өзара әрекет ету және сенім шаралары бойынша Кеңес Хатшылығы жұмысының рөлі аталып өтті. Оқыту курсының негізгі мақсаттары мен міндеттері жарияланды. 24 қатысушы-ел делегацияларының жұмыс принциптері еске салынды. Жаттығу нәтижелері ұсыныс принциптерінің5-ші нысанында көрсетілген.
ЭТИОЛОГИЧЕСКИЕ И КЛИНИЧЕСКИЕ ПРЕДИКТОРЫ ВОЗВРАТНОЙ ИШЕМИИ МИОКАРДА
Authors: Д.А. Мансурова , Л.К. Каражанова
Published: October 2024

В работе рассматривается проблема возврата симптомов ишемической болезни сердца (ИБС) у пациентов, перенесших реваскуляризацию миокарда (хирургическую и/или эндоваскулярную): распространенность факторов риска, особенности коронарного кровотока, «сосудистые» причины возвратной ишемии миокарда, вопросы приверженности к терапии. Целью нашего исследования было разработать эффективные меры вторичной профилактики для улучшения прогноза ИБС у пациентов после реваскуляризации миокарда. Обозначена важность создания обучающих школ для повышения информированности и приверженности к лечению.

The problem of return of symptoms of coronary heart disease (CHD) in patients undergoing myocardial revascularization (surgical and/or endovascular): prevalence of risk factors, especially in coronary blood flow, «vascular» causes recurrent myocardial ischemia, adherence to therapy considered in this work. The aim of our study was to develop effective measures to improve secondary prevention of CHD prognosis in patients after myocardial revascularization. The importance of the creation of training schools to raise awareness of and adherence to treatment denoted.

Бұл жұмыста миокард реваскуляризациясын (хирургиялық және/немесе эндоваскулярлы) өткерген науқастардағы жүректің ишемиялық ауруы(ЖИА) симптомдарының қайталану мәселесі қаралған: қауіп факторларының таралуы, тәждік қанайналым ерекшеліктері, қайталамамиокард ишемиясының «тамырлық» себептері, терапияға қажеттілік сұрақтары. Біздің зерттеуіміздің мақсаты миокард реваскуляризациясынан кейін науқастарда ЖИА болжамын жақсарту үшін екіншілік алдын алудың тиімді әдісін құрастыру. Емге қажеттілік пен ақпараттандыруды жоғарылату үшін үйрету мектептерін құру маңыздылығы көрсетілген.
ЗАКОНОМЕРНОСТИ ПЕРЕСТРОЙКИ ЛИМФОЦИРКУЛЯТОРНОГО РУСЛА ПОДМЫШЕЧНОЙ ОБЛАСТИ ПРИ РАКЕ МОЛОЧНОЙ ЖЕЛЕЗЫ
Authors: Ш.Х. Ганцев , Ш.Р. Кзыргалин , А.Н. Каюмова
Published: October 2024

Цель – выявить закономерности макроскопических изменений строения подмышечного лимфатического аппарата при раке молочной железы. Материал и методы.Объектами настоящего исследования послужили комплексы тканей, взятые у 100 лиц женского пола, во время хирургического вмешательства по поводу рака молочной железы и обработанные методом сонолиподеструкции. Результаты. Анализ лимфатических карт позволил разработать комбинированную схему градации функционального состояния лимфатических узлов и выделить (классифицировать) типы реструктурированного подмышечного лимфатического коллектора: «Последовательный», «Магистральный», «Равномерный», «Радиальный», «Сетчатый». Была подсчитана частота выявления того или иного типа подмышечного лимфатического аппарата. Заключение. Предлагаемая классификация является условной, не исключается вариант перехода одного типа подмышечного лимфатического коллектора в другой, то есть, возможно, это этапы одного процесса в различные зафиксированные моменты времени.

The aim is identify patterns of macroscopic changes in the structure of the axillary lymphatic system in breast cancer. Material and methods. The objects of this study were the complex tissue taken from 100 females, during surgery for breast cancer and treated by sonolipodestruction. Results. Analysis of lymph maps allowed to develop a combined functional state graduation scheme of the lymph nodes and highlight the types of axillary lymph collector restructured “Successive”, “Magistral”, “Uniform”, “Radial”, “Reticulated”. It was calculated incidence of a particular type of axillary lymphatic system. Conclusion. The proposed classification is conditional, not be excluded that the transition of one type of axillary lymph collector to another, that is, maybe it's the same process steps in various fixed points in time.

Мақсаты – cүт безі обыры кезіндегі қолтықасты лимфалық құрылғы құрылымының макроскопиялық өзгерістерінің заңнамалылығын анықтау. Материал және әдістері. Сүт безі обырына байланысты хирургиялық араласулар кезінде 100 әйелден алынған және сонолиподеструкция әдісімен өңделген тіндер кешені осы зерттеу нысандары болып қызмет етті. Нәтижелер. Лимфалық карталарды талдау лимфалық түйіндердің функционалдық жағдайы градациясының араласқан сұлбасын әдістеуге және қайта құрылымдалған қолтықастылық лимфалық коллектордың түрлерін бөлуге (жіктеуге) мүмкіндік береді: «Жүйелі», «Магистралды», «Бірқалыпты», «Радиалды», «Торлы». Айқындаудың сол немесе одан басқа қолтықастылық лимфалық құрылғы түрі жиілігі есептелген болатын. Қорытынды. Ұсынылған жіктеме шартты болып табылады, қолтықастылық лимфалық коллектордың бір түрінен бас түріне ауысу нұсқасы алып тасталмайды, яғни ол әртүрлі уақыттың белгіленген сәттеріне бір үрдістің кезеңдері болуы мүмкін.
UVULA EDEMA DUE TO ECBALİUM ELATERİUM
Authors: G. Kavalci , C. Kavalci
Published: October 2024

Ecballium Elaterium is a plant that grows in the Mediterranean. It is used as a folk remedy in the treatment of sinusitis. In this case report, we aimed to present a patient, who developed uvular edema due to the use of squirting cucumber. A 38-year-old female presented to our emergency department with the complaints of shortness of breath and difficulty swallowing. It should be remembered that the medicines used in traditional treatment methods can have fatal consequences.

Ecbalium elaterium (Бешенный огурец) - растение, произрастающее в Средиземном море. Используется как народное средство при лечении гайморита. В этом отчете мы хотели представить случай обращения пациентки, 38-летней женщины, обратившейся в отделение неотложной помощи с жалобами на одышку и затрудненное глотание. Был диагностирован увулярный отек языка из-за употребления в лечебных целях Ecbalium elaterium (бешенного огурца). Следует помнить, что лекарства, используемые в традиционных методах лечения, могут иметь фатальные последствия.

Ecbalium elaterium (құтырған қияр) - Жерорта теңізінде өсетін өсімдік.Гайморитті емдеуде халықтық ем ретінде қолданылады. Бұл есепте біз жедел жәрдем бөлімшесіне тыныс алу және жұтылу қиындықтары туралы шағымданған 38 жастағы әйелдің емделуін ұсынғымыз келді. Емдік мақсаттаEcbalium elaterium (құтырған қияр) қолдану салдарынан тілдің увулярлық ісінуі диагнозы қойылды. Дәстүрлі емдеуде қолданылатын дәрі-дәрмектер өлімге әкелуі мүмкін екенін есте ұстаған жөн.
«Оккультный» метастатический папиллярный рак щитовидной железы в современной клинической практике
Authors: М.В. Фридман , А.В. Прохоров
Published: October 2024

В статье представлены истории болезни трех пациенток с отдаленными метастазами «оккультного» папиллярного рака щитовидной железы (ПРЩЖ). Во всех наблюдениях по результатам клинического и инструментального исследования первичная локализация рака в щитовидной железе исключалась. Поражения легких/костей раз- вились у двух пациенток, ранее перенесших органосохранные операции по поводу узловых новообразований щитовидной железы. Еще в одном наблюдении метастазы ПРЩЖ в легких были ошибочно диагностированы как первичная периферическая аденокарцинома, и только обращение пациентки в поликлинику по поводу пневмонии COVID-19 спустя 15 лет после проведенного лечения позволило ретроспективно выявить истинную природу опухоли. Таким образом, интратиреоидная локализация и индолентные гистологические характеристики ПРЩЖ не позволяют исключить по- следующее поражение внутренних органов. Метастатический вариант «оккультного» ПРЩЖ может стать диагностической проблемой: история минимального хирургического лечения узловых образований щитовидной железы должна учитываться у пациентов с впервые обнаруженными метастазами в легких/костях.

The study aimed a clinical and morphological analysis of observations of "occult" papillary microcarcinoma of the thyroid gland in order to illustrate the problems that doctors of various specialties face when examining and treating patients. Objective diagnostic difficulties, as well as the lack of awareness about distant metastases of "occult" thyroid cancer are features that must be considered when analyzing this kind of observations at clinical and anatomical conferences or in forensic medical examinations. Therefore, clinical and morphological features of "occult" papillary thyroid cancer (PTC) with distant metastases in three patients were reported. The primary localization of cancer in the thyroid gland in all these observations was excluded based on the results of clinical and instrumental studies. Lung/bone lesions developed in two patients who had previously undergone organ-preserving surgical treatment of thyroid nodules. In another observation, PTC metastases in the lungs were mistakenly diagnosed as primary peripheral lung adenocarcinoma, and only the patient’s visit for COVID-19 pneumonia 15 years after treatment made it possible to identify the true nature of the tumour retrospectively. Thus, intrathyroidal localization and indolent histological characteristics per se were not associated with "harmful" biological behaviour. Metastatic variant of "occult" PTC can pose a diagnostic challenge: a history of minimal surgical treatment of thyroid nodules should be considered in patients with newly diagnosed lung/bone metastases.
Культурные и религиозные аспекты паллиативной помощи онкопациентам в Узбекистане: учет и уважение разнообразия
Authors: З.М. Мухамедова , А.Н. Махмудова
Published: October 2024

Паллиативная помощь – это комплексная медицинская, психологическая и социальная поддержка пациентов с неизлечимыми заболеваниями и их семей. В Узбекистане эта тема является актуальной, так как число онкологических пациентов, как и во всем мире, растет, а доступность и качество паллиативной помощи оставляют желать лучшего. В статье проводится анализ ситуации с паллиативной помощью онкопациентам в Узбекистане, сравнивается опыт других стран, выявляются проблемы и противоречия, а также предлагаются рекомендации по улучшению положения в этой сфере. Паллиативная помощь онкопациентам в Узбекистане требует комплексного и системного подхода, включающего усиление роли государства, повышение информированности и осведомленности населения, развитие кадрового потенциала и материально-технической базы, а также сотрудничество с международными и неправительственными организациями.

Palliative care is comprehensive medical, psychological and social support for patients with terminal illnesses and their families. In Uzbekistan, this topic is relevant, since the number of cancer patients, as throughout the world, is growing, and the availability and quality of palliative care leaves much to be desired. The article analyzes the situation with palliative care for cancer patients in Uzbekistan, compares the experience of other countries, identifies problems and contradictions, and also offers recommendations for improving the situation in this area. Palliative care for cancer patients in Uzbekistan requires an integrated and systematic approach, including strengthening the role of the state, increasing awareness of the population, developing human resources and material and technical base, as well as cooperation with international and non-governmental organizations. Purpose. To give a general picture of the state of palliative care for cancer patients in Uzbekistan, to identify its problems and prospects.
Динамика заболеваемости, возрастные и морфологические особенности первичных опухолей головного мозга (Самарканд)
Authors: А.Р. Акрамов , А.Ф. Асатулаев
Published: October 2024

Первичные опухоли головного мозга – это разнородная группа опухолей, различных по гистологическому строению, злокачественности и клиническому течению, общим для которых является происхождение из тканей, составляющих ЦНС и ее оболочки. В работе изучена динамика заболеваемости, морфологические и возрастные особенности опухолей головного мозга.

Primary tumors of the central nervous system unite tumors that differ in histological structure, malignancy and clinical course, common to them is their origin from the tissues that make up the central nervous system and its membranes. The work studied the dynamics of incidence, morphological and age-related characteristics of brain tumors.
Фармакоэкономическая позиция олапариба в поддерживающей терапии BRCA-ассоциированного распространенного рака яичников высокой степени злокачественности
Authors: А.П. Лис , А.В. Трухан , Е.В. Доломанова , С.А. Мавричев , М.С. Короленко , И.Н. Кожанова
Published: October 2024

В данной статье представлена фармакоэкономическая позиция олапариба в под-держивающей терапии BRCA-ассоциированного распространенного рака яичников высокой степени злокачественности. В ходе проведения «прецедентного» анализа ICUR, рассчитанный для олапариба, сравнивается с ICUR лекарственных препаратов, уже включенных в государственные ограничительные перечни, а именно с брентуксимабом, палбоциклибом и венетоклаксом. В результате установлено, что олапариб характеризуется меньшим значением ICUR – стоимостью одного дополнительного QALY, чем препараты венетоклакс и брентуксимаб, включенные в ограничительный перечень.

This article presents the pharmacoeconomic position of olaparib for maintenance therapy in patients with advanced BRCA-associated high-grade ovarian cancer. In a "precedent" analysis, the ICUR calculated for olaparib is compared with the ICUR of drugs already included in national health care system such as brentuximab, palbociclib, and venetoclax. The results show that olaparib has a lower ICUR (cost per additional QALY) than venetoclax and brentuximab, which are already included in the national health care system.
A taste for fruit: first record of Rekoa marius (Lucas, 1857) (Lepidoptera: Lycaenidae: Eumaeini) on Averrhoa carambola L. (Oxalidales: Oxalidaceae)
Authors: Cajé Suianne , Duarte-de-Mélo Jefferson , Suênia-Bastos Ayane , Moura Lima Iracilda Maria
Published: October 2024

Information on the natural history of Rekoa marius (Lucas, 1857) is presented through the first record of the species on Averrhoa carambola L. The larvae of this lepidopteran were collected on A. carambola and reared under laboratory conditions. Eggs were found on the flower bud, inflorescence and peduncle near the flower. All larval stages feed on flower buds, while the last larval stage also feeds on green and ripe fruits. Pupae with egress holes of different diameters were found, probably of parasitoids. Since Oxalidaceae species are rich in oxalic acid, R. marius may be a potential model for future studies on the mechanisms involved in the response of this species to oxalic acid present in its host plant.
First report of the genus Anchorius Casey, 1900 (Coleoptera: Biphyllidae) in Chile, with description of a new species
Authors: Tello Francisco , Tello-Arriagada Cristóbal
Published: October 2024

The genus Anchorius Casey, 1900 (Coleoptera: Biphyllidae) is reported for the first time in Chile. Based on the study of specimens from collections, Anchorius dollyae sp. nov. is described and illustrated. This new taxon is distinguished from other known Anchorius species by its distinctive distribution pattern of rows of pronotal setae, the presence of well-defined femoral lines and lateral lines of the first ventrite, incomplete metaventral discrimen, and different aedeagal morphology compared to morphologically similar species. This new species represents the southernmost record of this genus in South America. Finally, this finding provides new Anchorius habitat associations, including temperate and Mediterranean forests ecosystems in Chile.
Tradisi Perkawinan Adat Suku Sahu Dalam Perspektif Teologi Kristen di Jemaat GKPMI, Halmahera Barat
Authors: Ngamon Daud A , Nendissa Julio Eleazer , Rares Freby M.
Published: October 2024

The interaction of Christianity along with the traditions that have developed since the arrival of Christianity in North Maluku, so that the harmonization of Christian teachings and the traditions of the Sahu tribe's traditional marriage in life practices is still reflected in daily activities. The author uses qualitative descriptive analysis with theological, historical, sociological, and anthropological approaches. The research findings indicate that the stages and processes of the Sahu tribe's traditional marriage are moloara siri or osam golo'o, which consist of several phases, namely: di'dingoto (delivery), haka waro (finding out), golo'o masomoar (entering and asking for the usual), silolara, (leveling), oro namo ma ngina (taking the bride and traditional party). Then moloara masibidi (elopement), moloaramasingata'a or osam ino (marriage by delivering oneself), moloara ngali ngasu'u (marriage by changing poles), moloara tatanu (marriage by enslaving oneself in the mother-in-law's house), moloar si cako'o (elopement/raided), moloara rabasa ngowa'a manga were'a (marriage by stealing someone else's wife/husband). The acculturation of the Sahu tribe's customary marriage to Christian marriage has become one result, the essence of the Sahu tribe's customary marriage tradition blends with the Christian marriage system, and the Christian marriage system is harmonized with the Sahu tribe's customary marriage tradition, and the customary marriage system, church marriage, and government complement each other and become inseparable from these stages
Building Grit and Resilience - Commencement Speech By Dean Maglinao
Authors: Domingo-Maglinao Ma. Lourdes
Published: October 2024

This speech by Dean Ma. Lourdes Domingo-Maglinao, celebrates the accomplishments and resilience of the Class of 2024, highlighting the end of formal medical training and the beginning of a lifelong commitment to learning and service. The Dean emphasizes the journey ahead, underscoring the importance of grit and resilience—qualities developed through academic and personal challenges, which will be crucial as the graduates enter a demanding profession.
Editorial: Precision Medicine Meets AI
Authors: Rosales Raymond L
Published: October 2024

There are rapid advancements in AI-driven diagnostics and wearable technologies, which are enabling early disease prediction, especially in conditions like Parkinson's disease. Precision medicine, underpinned by molecular biology and genomic data, allows clinicians to tailor treatment based on patient phenotypes, significantly enhancing personalized healthcare. AI complements this by processing vast datasets, from health records to biomarker evaluations, supporting more precise diagnostics and treatment recommendations.