bluuebunny/crossref_metadata_2025 huggingface dataset:
Intermittent Fasting in Breast Cancer: A Systematic Review and Critical Update of Available Studies
Authors: Anemoulis Marios , Vlastos Antonios , Kachtsidis Vasileios , Karras Spyridon N.
Published: January 2023

Breast cancer (BC) is the most-frequent malignancy amongst women, whereas obesity and excess caloric consumption increase the risk for developing the disease. The objective of this systematic review was to examine the impact of intermittent fasting (IF) on previously diagnosed BC patients, regarding quality of life (QoL) scores during chemotherapy, chemotherapy-induced toxicity, radiological response and BC recurrence, endocrine-related outcomes, as well as IF-induced adverse effects in these populations. A comprehensive search was conducted between 31 December 2010 and 31 October 2022, using the PubMed, CINAHL, Cochrane, Web of Science, and Scopus databases. Two investigators independently performed abstract screenings, full-text screenings, and data extraction, and the Mixed Method Appraisal Tool (MMAT) was used to evaluate the quality of the selected studies. We screened 468 papers, 10 of which were selected for data synthesis. All patients were female adults whose age ranged between 27 and 78 years. Participants in all studies were women diagnosed with BC of one of the following stages: I, II (HER2−/+), III (HER2−/+), IV, LUMINAL-A, LUMINAL-B (HER2−/+). Notably, IF during chemotherapy was found to be feasible, safe and able to relieve chemotherapy-induced adverse effects and cytotoxicity. IF seemed to improve QoL during chemotherapy, through the reduction of fatigue, nausea and headaches, however data were characterized as low quality. IF was found to reduce chemotherapy-induced DNA damage and augmented optimal glycemic regulation, improving serum glucose, insulin, and IGF-1 concentrations. A remarkable heterogeneity of duration of dietary patterns was observed among available studies. In conclusion, we failed to identify any IF-related beneficial effects on the QoL, response after chemotherapy or related symptoms, as well as measures of tumor recurrence in BC patients. We identified a potential beneficial effect of IF on chemotherapy-induced toxicity, based on markers of DNA and leukocyte damage; however, these results were derived from three studies and require further validation. Further studies with appropriate design and larger sample sizes are warranted to elucidate its potential standard incorporation in daily clinical practice.
Acknowledgment to the Reviewers of Oxygen in 2022
Authors:   Oxygen Editorial Office
Published: January 2023

High-quality academic publishing is built on rigorous peer review [...]
Epidemiological, Clinical, and Virological Investigation of the First Four Cases of Monkeypox in Cartagena during the 2022 Outbreak
Authors: Loyola Steev , Fernández-Ruiz Mashiel , Gómez-Camargo Doris
Published: January 2023

Since early May 2022, numerous cases of Monkeypox (Mpox) have been reported globally in non-endemic areas. However, despite numerous reports worldwide, the epidemiological and genomic information related to the 2022 multi-country outbreak remains scarce in South America. By late June 2022, the first Mpox cases were detected in Colombia. Cartagena is a Colombian Caribbean city with high domestic and international connectivity, and, therefore, is vulnerable to the introduction of the Monkeypox virus (MPXV). This report provides an in-depth description of the epidemiological, clinical, and virological characteristics of the first four cases detected in Cartagena including three cases with no history of recent travel and one imported case. Using various laboratory tools based on PCR, next-generation sequencing, and viral isolation and quantification methods, the MPXV clade IIB was detected and isolated. Importantly, infectious viral particles were identified in lesion swabs collected from all cases and in oropharyngeal swabs collected from two cases. Blood samples tested negative using PCR and isolation. In summary, our work contributes complete genomic, clinical, and epidemiological information that will be useful for a number of studies going forward, and it also documents local information that contributes to our understanding of Mpox at the local level.
Do We Have Enough Evidence to Specifically Recommend Transoral Robotic Surgery in HPV−Driven Oropharyngeal Cancer? A Systematic Review
Authors: De Virgilio Armando , Costantino Andrea , Rizzo Davide , Crescio Claudia , Gallus Roberto , Spriano Giuseppe , Mercante Giuseppe , Festa Bianca Maria , Accorona Remo , Pignataro Lorenzo , Capaccio Pasquale , Bussu Francesco
Published: January 2023

Introduction: International guidelines include transoral robotic surgery (TORS) as an option for selected oropharyngeal squamous cell carcinomas (OPSCCs). In the perspective of treatment de-intensification, many surgeons have started recommending and performing TORS preferentially in p16- positive OPSCC in order to reduce the long-term morbidity related to chemoradiotherapy. The aim of the present review is to analyze the current evidence supporting the above-cited strategy. Materials and Methods: The study was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Results: Twenty-two studies were included in this review, with a total of 3992 patients treated with primary TORS. The majority of patients were classified as HPV+ (n = 3655, 91.6%), and 8.2% (n = 327) as HPV−. The HPV status was unknown in only 10 (0.3%) patients. In particular, only five of the included studies compared survival outcomes of HPV−positive patients with HPV−negative ones treated with primary TORS, and only two of these found a significant improvement in survival in the HPV−driven cohort. Discussion: The current literature does not clarify whether HPV+ OPSCCs treated with TORS, alone or with adjuvant treatments, are associated with a better oncologic and/or functional outcome compared to those treated with radio- or chemoradiotherapy. However, TORS alone obtained good oncological outcomes in a high percentage of cases in the reviewed series. Recent data, on the other hand, suggest that TORS could represent a promising strategy for intensifying treatments in HPV− OPSCC.
The Effects of Hydrogen-Rich Water on Blood Lipid Profiles in Clinical Populations: A Systematic Review and Meta-Analysis
Authors: Todorovic Nikola , Fernández-Landa Julen , Santibañez Asier , Kura Branislav , Stajer Valdemar , Korovljev Darinka , Ostojic Sergej M.
Published: January 2023

Over the last two decades, a plethora of disease models and human studies have confirmed the beneficial effects of molecular hydrogen (H2), a simple biotherapeutic gas. Recent small-scale studies evaluating the effects of hydrogen-rich water (HRW) on various metabolic conditions pointed to advantageous effects of HRW in regulating blood lipid profiles. However, to the best of the authors’ knowledge, no systematic review and/or meta-analysis (SRMA) were published considering HRW consumption and lipid/lipoprotein status. Therefore, the aim of this SRMA was to assess the effects of HRW consumption on blood lipid panel in clinical populations. The search strategy was designed using PRISMA guidelines, and the databases PubMed/Medline, Web of Science, and Scopus were explored from inception until 4 October 2022. A total of seven studies satisfied all the eligibility criteria and were included in SRMA. The results for the pooled meta-analysis showed a significant reduction in total cholesterol, low-density lipoprotein, and triglycerides after HRW intake (p = 0.01), with small to moderate effects (pooled SMD = −0.23 (from −0.40 to 0.05); pooled SMD = −0.22 (from −0.39 to 0.04); pooled SMD = −0.38 (from −0.59 to 0.18), respectively). Our findings indicate that drinking HRW can significantly improve lipid status in the clinical populations. Additional studies are warranted to further validate this connection.
Piperine–Chlorogenic Acid Hybrid Inhibits the Proliferation of the SK-MEL-147 Melanoma Cells by Modulating Mitotic Kinases
Authors: Pressete Carolina , Viegas Flávia Pereira Dias , Campos Thâmara Gaspar , Caixeta Ester Siqueira , Hanemann João Adolfo Costa , Ferreira-Silva Guilherme Álvaro , Zavan Bruno , Aissa Alexandre Ferro , Miyazawa Marta , Viegas Claudio , Ionta Marisa
Published: January 2023

Melanoma is considered the most aggressive form of skin cancer, showing high metastatic potential and persistent high mortality rates despite the introduction of immunotherapy and targeted therapies. Thus, it is important to identify new drug candidates for melanoma. The design of hybrid molecules, with different pharmacophore fragments combined in the same scaffold, is an interesting strategy for obtaining new multi-target and more effective anticancer drugs. We designed nine hybrid compounds bearing piperine and chlorogenic acid pharmacophoric groups and evaluated their antitumoral potential on melanoma cells with distinct mutational profiles SK-MEL-147, CHL-1 and WM1366. We identified the compound named PQM-277 (3a) to be the most cytotoxic one, inhibiting mitosis progression and promoting an accumulation of cells in pro-metaphase and metaphase by altering the expression of genes that govern G2/M transition and mitosis onset. Compound 3a downregulated FOXM1, CCNB1, CDK1, AURKA, AURKB, and PLK1, and upregulated CDKN1A. Molecular docking showed that 3a could interact with the CUL1-RBX1 complex, which activity is necessary to trigger molecular events essential for FOXM1 transactivation and, in turn, G2/M gene expression. In addition, compound 3a effectively induced apoptosis by increasing BAX/BCL2 ratio. Our findings demonstrate that 3a is an important antitumor candidate prototype and support further investigations to evaluate its potential for melanoma treatment, especially for refractory cases to BRAF/MEK inhibitors.
Metabolism-Guided Optimization of Tryptophanol-Derived Isoindolinone p53 Activators
Authors: Barcherini Valentina , Loureiro Joana B. , Sena Ana , Madeira Catarina , Leandro Paula , Saraiva Lucília , Antunes Alexandra M. M. , Santos Maria M. M.
Published: January 2023

For the first time, the pharmacokinetic (PK) profile of tryptophanol-derived isoindolinones, previously reported as p53 activators, was investigated. From the metabolites’ identification, performed by liquid chromatography coupled to high resolution tandem mass spectrometry (LC-HRMS/MS), followed by their preparation and structural elucidation, it was possible to identify that the indole C2 and C3 are the main target of the cytochrome P450 (CYP)-promoted oxidative metabolism in the tryptophanol-derived isoindolinone scaffold. Based on these findings, to search for novel p53 activators a series of 16 enantiopure tryptophanol-derived isoindolinones substituted with a bromine in indole C2 was prepared, in yields of 62–89%, and their antiproliferative activity evaluated in human colon adenocarcinoma HCT116 cell lines with and without p53. Structural optimization led to the identification of two (S)-tryptophanol-derived isoindolinones 3.9-fold and 1.9-fold more active than hit SLMP53-1, respectively. Compounds’ metabolic stability evaluation revealed that this substitution led to a metabolic switch, with the impact of Phase I oxidative metabolism being minimized. Through differential scanning fluorimetry (DSF) experiments, the most active compound of the series in cell assays led to an increase in the protein melting temperature (Tm) of 10.39 °C, suggesting an effective binding to wild-type p53 core domain.
KIF1A-Associated Neurological Disorder: An Overview of a Rare Mutational Disease
Authors: Nair Ayushi , Greeny Alosh , Rajendran Rajalakshmi , Abdelgawad Mohamed A. , Ghoneim Mohammed M. , Raghavan Roshni Pushpa , Sudevan Sachithra Thazhathuveedu , Mathew Bijo , Kim Hoon
Published: January 2023

KIF1A-associated neurological diseases (KANDs) are a group of inherited conditions caused by changes in the microtubule (MT) motor protein KIF1A as a result of KIF1A gene mutations. Anterograde transport of membrane organelles is facilitated by the kinesin family protein encoded by the MT-based motor gene KIF1A. Variations in the KIF1A gene, which primarily affect the motor domain, disrupt its ability to transport synaptic vesicles containing synaptophysin and synaptotagmin leading to various neurological pathologies such as hereditary sensory neuropathy, autosomal dominant and recessive forms of spastic paraplegia, and different neurological conditions. These mutations are frequently misdiagnosed because they result from spontaneous, non-inherited genomic alterations. Whole-exome sequencing (WES), a cutting-edge method, assists neurologists in diagnosing the illness and in planning and choosing the best course of action. These conditions are simple to be identified in pediatric and have a life expectancy of 5–7 years. There is presently no permanent treatment for these illnesses, and researchers have not yet discovered a medicine to treat them. Scientists have more hope in gene therapy since it can be used to cure diseases brought on by mutations. In this review article, we discussed some of the experimental gene therapy methods, including gene replacement, gene knockdown, symptomatic gene therapy, and cell suicide gene therapy. It also covered its clinical symptoms, pathogenesis, current diagnostics, therapy, and research advances currently occurring in the field of KAND-related disorders. This review also explained the impact that gene therapy can be designed in this direction and afford the remarkable benefits to the patients and society.
Thermal Sensitivity of Birefringence in Polarization-Maintaining Hollow-Core Photonic Bandgap Fibers
Authors: Wang Lidong , Liao Meisong , Yu Fei , Li Weichang , Xu Jiacheng , Hu Lili , Gao Weiqing
Published: January 2023

Polarization-maintaining (PM) fiber is the core sensitive component of a fiber optic gyroscope (FOG); its birefringence temperature stability is crucial for maintaining accuracy. Here, we systematically investigated the structural thermal deformation and the resulting birefringence variation in typical PM hollow-core photonic bandgap fibers (HC-PBGFs) for FOG according to varying fiber structure parameters. To verify the application potential of PM HC-PBGFs in FOG, we compared the thermal sensitivity of birefringence (TSB) with that of the commonly used Panda PM fiber, which was tested to 5.07 × 10−5/100 °C. For rhombic-core fibers, the TSB was determined by the structure of the cladding and could be tuned as low as low as 10−7/100 °C, two orders of magnitude smaller than that of the panda PM fibers. For hexagonal-core fibers, the birefringence variation depended mainly on the drift of the surface modes (SMs) caused by the deformation of the core. A slight drift in SMs could cause a dramatic birefringence variation in hexagonal-core fiber, and the TSB could be as high as 10−4/100 °C, much higher than that of panda PM fiber. This study lays the foundation for the development of high birefringence temperature-stable HC-PBGFs and their applications in FOG.
Quantum Configuration and Phase Spaces: Finsler and Hamilton Geometries
Authors: Albuquerque Saulo , Bezerra Valdir B. , Lobo Iarley P. , Macedo Gabriel , Morais Pedro H. , Rodrigues Ernesto , Santos Luis C. N. , Varão Gislaine
Published: January 2023

In this paper, we reviewtwo approaches that can describe, in a geometrical way, the kinematics of particles that are affected by Planck-scale departures, named Finsler and Hamilton geometries. By relying on maps that connect the spaces of velocities and momenta, we discuss the properties of configuration and phase spaces induced by these two distinct geometries. In particular, we exemplify this approach by considering the so-called q-de Sitter-inspired modified dispersion relation as a laboratory for this study. We finalize with some points that we consider as positive and negative ones of each approach for the description of quantum configuration and phases spaces.
Chloroplast Envelopes Play a Role in the Formation of Autophagy-Related Structures in Plants
Authors: Yanagisawa Makoto , Chuong Simon D. X.
Published: January 2023

Autophagy is a degradation process of cytoplasmic components that is conserved in eukaryotes. One of the hallmark features of autophagy is the formation of double-membrane structures known as autophagosomes, which enclose cytoplasmic content destined for degradation. Although the membrane source for the formation of autophagosomes remains to be determined, recent studies indicate the involvement of various organelles in autophagosome biogenesis. In this study, we examined the autophagy process in Bienertia sinuspersici: one of four terrestrial plants capable of performing C4 photosynthesis in a single cell (single-cell C4 species). We demonstrated that narrow tubules (stromule-like structures) 30–50 nm in diameter appear to extend from chloroplasts to form the membrane-bound structures (autophagosomes or autophagy-related structures) in chlorenchyma cells of B. sinuspersici during senescence and under oxidative stress. Immunoelectron microscopic analysis revealed the localization of stromal proteins to the stromule-like structures, sequestering portions of the cytoplasm in chlorenchyma cells of oxidative stress-treated leaves of B. sinuspersici and Arabidopsis thaliana. Moreover, the fluorescent marker for autophagosomes GFP-ATG8, colocalized with the autophagic vacuole maker neutral red in punctate structures in close proximity to the chloroplasts of cells under oxidative stress conditions. Together our results implicate a role for chloroplast envelopes in the autophagy process induced during senescence or under certain stress conditions in plants.
Environmental Factors Regulate Plant Secondary Metabolites
Authors: Qaderi Mirwais M. , Martel Ashley B. , Strugnell Courtney A.
Published: January 2023

Abiotic environmental stresses can alter plant metabolism, leading to inhibition or promotion of secondary metabolites. Although the crucial roles of these compounds in plant acclimation and defense are well known, their response to climate change is poorly understood. As the effects of climate change have been increasing, their regulatory aspects on plant secondary metabolism becomes increasingly important. Effects of individual climate change components, including high temperature, elevated carbon dioxide, drought stress, enhanced ultraviolet-B radiation, and their interactions on secondary metabolites, such as phenolics, terpenes, and alkaloids, continue to be studied as evidence mounting. It is important to understand those aspects of secondary metabolites that shape the success of certain plants in the future. This review aims to present and synthesize recent advances in the effects of climate change on secondary metabolism, delving from the molecular aspects to the organismal effects of an increased or decreased concentration of these compounds. A thorough analysis of the current knowledge about the effects of climate change components on plant secondary metabolites should provide us with the required information regarding plant performance under climate change conditions. Further studies should provide more insight into the understanding of multiple environmental factors effects on plant secondary metabolites.
The Overall Environmental Load and Resistance Risk Caused by Long-Term Fungicide Use to Control Venturia inaequalis in Apple Orchards in Latvia
Authors: Rancāne Regīna , Valiuškaitė Alma , Zagorska Viktorija , Komašilovs Vitālijs , Rasiukevičiūtė Neringa
Published: January 2023

Apple orchards are perennially planted where pesticides are applied to control numerous pests and diseases. The extensive long-term use of fungicides can lead to overall environmental load and resistance risk. This study aims to assess which fungicide-active substances have been used more intensively in the last decade in Latvia, evaluating the overall environmental load using the Pesticide Load Indicator (PLI). It was essential to see whether the amount of active substance usage rises, how it correlates with the total changes of the PLI and which substances are with the highest scores. The other issue was to test the sensitivity of Venturia inaequalis populations to systemic fungicides. Six full-bearing apple orchards that reflected local plant protection practices were selected from the different growing regions of Latvia to analyze fungicide use from 2012 to 2021 and test V. inaequalis populations’ sensitivity to systemic substances difenoconazole and cyprodinil. The PLI demonstrated that the protective fungicides were the most crucial group overall, with the highest potential impact on the environment and human health. Systemic fungicides had a relatively lower environmental impact, but after long-term use, the pathogen population’s sensitivity to difenoconazole and cyprodinil was reduced. Introducing new fungicide classes and biological control agents could help growers improve plant protection strategies against V. inaequalis, reducing the risk of resistance and environmental load.
Accumulation of Plastics and Trace Elements in the Mangrove Forests of Bima City Bay, Indonesia
Authors: Moniuszko Hanna , Malonga Win Ariga Mansur , Koczoń Piotr , Thijs Sofie , Popek Robert , Przybysz Arkadiusz
Published: January 2023

Pollution with microplastics (MPs), nanoplastics (NPs) and trace elements (TEs) remains a considerable threat for mangrove biomes due to their capability to capture pollutants suspended in the water. This study investigated the abundance and composition of plastics and TEs contained in the soil and pneumatophores of Avicennia alba sampled in experimental areas (hotel, market, river mouth, port, and rural areas) differentiated in anthropopressure, located in Bima Bay, Indonesia. Polymers were extracted and analyzed with the use of a modified sediment isolation method and Fourier transform infrared spectroscopy. Trace elements were detected by inductively coupled plasma optical emission spectrometry. The lowest and highest quantities of MPs in soil were recorded in rural and hotel areas, respectively. The rural site was characterized by distinct MP composition. The amounts of sediment-trapped MPs in the tested localities should be considered as high, and the recognized polymers partly corresponded with local human activity. Concentrations of seven plastic types found in plant tissues did not entirely reflect sediment pollution with nine types, suggesting a selective accumulation (particularly of polyamides and vinylidene chloride) and substance migration from other areas. Very low concentrations of non-biogenic TEs were observed, both in sediments and pneumatophores. The results highlight the relevance of environmental contamination with plastics.
Horticultural Practices in Early Spring to Mitigate the Adverse Effect of Low Temperature on Fruit Set in ‘Lapins’ Sweet Cherry
Authors: Xu Hao , Ediger Danielle , Sharifi Mehdi
Published: January 2023

Yield of sweet cherry (Prunus avium L.) is determined by fruit set, a developmental stage sensitive to variable spring environmental conditions. To sustain fruit production and enhance crop climate resilience, it is important to understand the impacts of abiotic stresses and the effectiveness of horticultural mitigations in the spring on the critical developmental processes during fruit set. In this study, flowering phenology, pistil browning and percent fruit set of ‘Lapins’ were monitored at five sites of different elevation and frost risk in the Okanagan Valley, British Columbia, Canada, in 2019 and 2022. At Site 1 in Summerland Research and Development Centre (“SuRDC1”), where a ‘Lapins’ on Krymsk 5 planting was located in a frost pocket where the crops were exposed to high risk of cold damage in the spring, a series of experiments were conducted to investigate the floral organ viability and percent fruit set under low temperatures, and under the effects of four spring horticultural mitigation measures. Installation of polyethylene sleeves and FAME spray (fatty acid methyl esters-based plant growth regulator, WAIKEN, SST Australia) were implemented in 2019; boric acid spray and postponed irrigation were tested in 2022. Low fruit set at SuRDC1 in both years was associated with severe pistil browning after night temperature dropped below −4 °C in late April. In 2019, the semi-enclosure of polyethylene sleeves led to an increase in the surface temperature (Tsurfae) of floral buds by 2–4 °C, which prolonged the stage of first bloom, delayed petal fall and prevented frost damage on pistils, but led to the decrease in percent fruit set by 77%, due to ovule abortion or cessation of fruitlet development. The early and late sprays of FAME had no significant influence on either abundance of germinated pollen tubes or percent fruit set; however, the potential of late spray in improving pollen abundance and reducing pistil browning requires further investigation. In 2022, the spray of 0.01% boric acid solution led to a decrease in fruit set by 6.95%. Six-week postponement of irrigation starting from full bloom decreased soil moisture, but increased soil temperature and improved fruit set by 7.61%. The results improved our understanding about the damages of adverse spring air temperatures on pistils and ovules, and suggested the potential of irrigation adjustment in regulating soil moisture and temperature and improving fruit set in the cool and moist spring.
Experimental and Hybrid FEM/Peridynamic Study on the Fracture of Ultra-High-Performance Concretes Reinforced by Different Volume Fractions of Polyvinyl Alcohol Fibers
Authors: Zhang Kun , Ni Tao , Zhang Jin , Wang Wen , Chen Xi , Zaccariotto Mirco , Yin Wei , Zhu Shengxue , Galvanetto Ugo
Published: January 2023

In this study, a series of three-point bending tests were carried out with notched beam structures made of polyvinyl alcohol (PVA) fiber-reinforced ultra-high-performance concrete (UHPC) to study the effect of volume fractions of PVA fibers on the fracture characteristics of the UHPC-PVAs. Furthermore, in order to meet the increasing demand for time- and cost-saving design methods related to research and design experimentation for the UHPC structures, a relevant hybrid finite element and extended bond-based peridynamic numerical modeling approach is proposed to numerically analyze the fracture behaviors of the UHPC-PVA structures in 3D. In the proposed method, the random distribution of the fibers is considered according to their corresponding volume fractions. The predicted peak values of the applied force agree well with the experimental results, which validates the effectiveness and accuracy of the present method. Both the experimental and numerical results indicate that, increasing the PVA fiber volume fraction, the strength of the produced UHPC-PVAs will increase approximately linearly.
Temperature Effects on the Crystalline Structure of iPP Containing Different Solvent-Treated TMB-5 Nucleating Agents
Authors: Luo Baojing , Xu Sheng , Yang Jing , Zhang Qing , Yu Jing , Liu Lihua , Meng Xiangjun
Published: January 2023

TMB-5 nucleating agent (NA) treated by different solvents were used as the β-NA of iPP. The effects of temperature on the crystalline structure of different iPP/TMB-5, as well as the crystallization and melting behaviors were investigated. It was found that strong polar solvent treated TMB-5 (TMB-5DMSO and TMB-5DMF) could induce more β-crystal at high Tc = 140 °C than the other TMB-5 NAs, while the β-crystal inducing efficiency of untreated TMB-5 (TMB-5UT) and non-polar solvent treated TMB-5 (TMB-5LP) is seriously reduced at high Tc = 140 °C. TMB-5DMSO can induce a high and stable content of β-crystal with Kβ = 83–94% within Tc = 90–140 °C, and TMB-5ODCB can induce a high content of β-crystal with Kβ > 91.3% within Tc = 90–130 °C. TMB-5DMF is the most temperature-sensitive one, but can induce a high fraction of β-crystal with Kβ > 92% both at low Tc = 90 °C and high Tc = 140 °C. High temperature pre-crystallization at Tpc = 150 °C tremendously reduces the β-crystal inducing efficiency of all TMB-5 NAs. TMB-5UT and TMB-5LP exhibit higher nucleating efficiency than TMB-5DMSO, TMB-5DMF and TMB-5ODCB. During the non-isothermal crystallization process, TMB-5UT induced β-crystal possesses higher structural perfection and stability, while TMB-5LP is more likely to induce α-crystal with considerable quantity and stability. The structural perfection and stability of TMB-5 induced β-crystal can be enhanced with appropriate increasing of Tc.
Enhancement of Self-Healing Efficacy of Conductive Nanocomposite Hydrogels by Polysaccharide Modifiers
Authors: Tomić Nataša Z. , Ghodhbane Myriam , Matouk Zineb , AlShehhi Nujood , Busà Chiara
Published: January 2023

The proper design of a polysaccharide/hydrocolloid modifier significantly affects the conductivity, self-healing, and viscoelastic properties of nanocomposite hydrogels. Due to the presence of different functional groups, these hydrogels can participate in the covalent, hydrogen and dynamic bonding of a system. The improvement of interactions in this system can lead to the development of high-performance nanocomposite hydrogels. In this study, resilient, self-healing and self-adhesive conductive nanocomposite hydrogels were produced by multiple and diverse coordination connections between various polysaccharide-based modifiers (Arabic gum, sodium carboxymethyl cellulose, and xanthan), the poly(vinyl alcohol) (PVA) network and different graphene-based fillers. Graphene nanoplatelets (GNP), activated carbon black (ACB), and reduced graphene oxide (rGO) have distinct functionalized surfaces, which were analyzed by X-ray photoelectron spectroscopy (XPS). Furthermore, the introduction of fillers balanced the hydrogels’ viscoelastic properties and electrical conductivity, providing the hydrogels with resilience, improved electrical conductivity, and extreme stretchability (5000%). The self-healing properties were analyzed using time-dependent measurements in a shear strain mode using an RSO Rheometer. The improvement in electrochemical and conductivity properties was confirmed by electrochemical impedance spectroscopy (EIS). The obtained conductive nanocomposite hydrogels design opens new possibilities for developing high-performance polysaccharide-based hydrogels with wearable electrical sensors and healthcare monitoring applications.
Sustainable Cement Composite Integrating Waste Cellulose Fibre: A Comprehensive Review
Authors: Fernando Sarah , Gunasekara Chamila , Shahpasandi Amin , Nguyen Kate , Sofi Massoud , Setunge Sujeeva , Mendis Priyan , Rahman Md. Tareq
Published: January 2023

This review presents the research conducted to date in the field of cement-based composites reinforced with waste paper-based cellulose fibres, focusing on their composition, mechanical properties, and durability characteristics. The literature demonstrates that the properties of raw material (depending on their own chemical composition) significantly influence the formation of the cement composite binders. When considering fresh properties, the presence of silica and magnesium compounds generally lead to favourable effects on the setting of the cement composite when combined with waste paper cellulose fibre. Reduction in density values, i.e., approximately 25%, was observed with the inclusion of waste paper fibres from 20 to 80% in cement composites. The homogeneous dispersion of fibres in the matrix is one of the crucial factors to achieve in order to develop composites with well-balanced mechanical properties incorporating waste paper cellulose fibres. Hence, dispersion of fibres can be improved by increasing water quantity corresponding to the optimal value, which was a water/cement ratio of 0.64 leading to optimum strength properties of the composite. Even though the effect of fibre dispersion in the matrix improves with the addition of water, higher porosity and voids govern the strength properties beyond an optimum water-to-cement ratio. Higher porosity leads to an increase in the water absorption and a lowering of the thermal conductivity properties with the addition of paper fibre in cement binders. Paper fibre absorbs a high amount of water leading to higher water absorption. This phenomenon is related to the hydrophilic nature of cellulosic fibres absorbing some volume of water due to their microporous structure.
Shedding Light on Degradation Gradients in Celluloid: An ATR-FTIR Study of Artificially and Naturally Aged Specimens
Authors: Chavez Lozano Marco Valente , Elsässer Christina , Angelin Eva Mariasole , Pamplona Marisa
Published: January 2023

Celluloid artifacts are known by conservation professionals to be prone to degradation, threatening their own integrity and that of nearby heritage collections. Celluloid alteration can have a heterogeneous nature, and this research topic is still in its infancy for heritage science. This article investigates degradation gradients, both along depth and width, of artificially aged celluloid sheets, and compares them to three-dimensional (3D) historical objects with the aim of gaining a better insight into the nature and evolution of their decay. ATR-FTIR was used to systematically study different sampling points of the artificially and naturally aged specimens and allowed us to recognize better-preserved surfaces and more deteriorated cores. ATR-FTIR was found suitable for assessing the molecular changes induced by degradation, particularly denitration and formation of carbonyl-containing degradation products in severely aged specimens. Even though the severely artificially aged sheets displayed unusual alteration phenomena, they present a degradation gradient similar to the one observed for the naturally aged 3D objects under study. This research underlines that sampling at different depths and/or widths is relevant for characterizing the heterogeneity of degraded celluloid, and further investigation with chromatographic techniques would greatly benefit the understanding of the complex degradation of celluloid artifacts.
Experimental Study on Mechanical Behavior and Energy Evolution Characteristics of Gas-Filled Deep Coal under Cyclic Loading
Authors: Jiang Junjun , Zhang Yong , Deng Zhigang , Ren Weiguang , Zhang Guanghui
Published: January 2023

To study the mechanical behavior and energy evolution law of gas-filled deep coal, conventional triaxial compression experiments under different confining pressure and gas pressure conditions and cyclic loading and unloading experiments under different gas pressures were carried out. The failure characteristics and mechanical parameters evolution of two loading modes were analyzed. In addition, the energy density and ratio evolution law under cyclic loading was revealed, and based on these findings, an attempt was made to depict the relation of cumulative dissipated energy density and volumetric strain by fitting the experimental data. The results indicated that failure of coal is expressed as a single shear surface under conventional compression, while under cyclic loading mode, coal behaves with multi-fracture crushing failure. Mechanical parameters showed a trend of decay with increasing gas pressure, and that cyclic loading and unloading increases the bearing capacity of coal by 8–38%. The dissipated energy density and ratio grew significantly when coal entered the yield stage. In the compaction stage, the cumulative dissipated energy density rose with volumetric strain in the form of an exponential function, and it increased with relative volumetric strain as a power function.
A Three-Step Framework for Multimodal Industrial Process Monitoring Based on DLAN, TSQTA, and FSBN
Authors: Wu Hao , Fu Wangan , Ren Xin , Wang Hua , Wang Enmin
Published: January 2023

The process monitoring method for industrial production can technically achieve early warning of abnormal situations and help operators make timely and reliable response decisions. Because practical industrial processes have multimodal operating conditions, the data distributions of process variables are different. The different data distributions may cause the fault detection model to be invalid. In addition, the fault diagnosis model cannot find the correct root cause variable of system failure by only identifying abnormal variables. There are correlations between the trend states of the process variables. If we do not consider these correlations, this may result in an incorrect fault root cause. Therefore, multimodal industrial process monitoring is a tough issue. In this paper, we propose a three-step framework for multimodal industrial process monitoring. The framework aims for multimodal industrial processes to detect the faulty status timely and then find the correct root variable that causes the failure. We present deep local adaptive network (DLAN), two-stage qualitative trend analysis (TSQTA), and five-state Bayesian network (FSBN) to implement fault detection, identification, and diagnosis step by step. This framework can detect the system failure timely, identify abnormal variables, and find the root cause variable and the fault propagation path. The case studies on the Tennessee Eastman simulation and a practical chlorobenzene production process are provided to verify the effectiveness of the proposed framework in multimodal industrial process monitoring.
Dendrimers in Neurodegenerative Diseases
Authors: Pérez-Carrión María Dolores , Posadas Inmaculada
Published: January 2023

Neurodegenerative diseases (NDs), such as Parkinson’s Disease (PD), Alzheimer’s Disease (AD), Multiple Sclerosis (MS) and amyotrophic lateral sclerosis (ALS), are characterized by progressive loss of structure or function of neurons. Current therapies for NDs are only symptomatic and long-term ineffective. This challenge has promoted the development of new therapies against relevant targets in these pathologies. In this review, we will focus on the most promising therapeutic approaches based on dendrimers (DDs) specially designed for the treatment and diagnosis of NDs. DDs are well-defined polymeric structures that provide a multifunctional platform for developing different nanosystems for a myriad of applications. DDs have been proposed as interesting drug delivery systems with the ability to cross the blood–brain barrier (BBB) and increase the bioavailability of classical drugs in the brain, as well as genetic material, by reducing the synthesis of specific targets, as β-amyloid peptide. Moreover, DDs have been shown to be promising anti-amyloidogenic systems against amyloid-β peptide (Aβ) and Tau aggregation, powerful agents for blocking α-synuclein (α-syn) fibrillation, exhibit anti-inflammatory properties, promote cellular uptake to certain cell types, and are potential tools for ND diagnosis. In summary, DDs have emerged as promising alternatives to current ND therapies since they may limit the extent of damage and provide neuroprotection to the affected tissues.
Research on Gas Control Technology of “U+ Omni-Directional Roof to Large-Diameter High-Level Drilling Hole” at the End Mining Face of Multi-Source Goaf
Authors: Gao Hong , Lei Yun
Published: January 2023

Aiming at the gas over-run problem in the upper corner of the “U-type ventilation” end-mining working face in the multi-source goaf of the #15 coal seam in the Phoenix Mountain Mine, site survey and numerical simulation methods were adopted, which showed that the maximum caving zone height of the #15 coal seam is 14.87 m, and the maximum height of the fissure zone is 51.63 m. On this basis, the gas control scheme of the “U+ omni-directional large-diameter high-level borehole along roof strike” in the end-mining working face was formulated. After adopting this scheme, the extracted gas concentration of each borehole will reach 5–20%, the gas extraction flow rate will reach 1 m3/min–2.5 m3/min, the gas concentration at the upper corner of the working face will be controlled below 0.54%, and the gas concentration in the return airway will be controlled below 0.35%, achieving the expected effect of gas control.
Optimization of Heat Recovery Networks for Energy Savings in Industrial Processes
Authors: Lee Jui-Yuan , Chen Po-Yu
Published: January 2023

Among the pillars of decarbonization of the global energy system, energy efficiency plays a key role in reducing energy consumption across end-use (industry, transport and buildings) sectors. In industrial processes, energy efficiency can be improved by exploiting heat recovery via heat exchange between process streams. This paper develops a stage-wise superstructure-based mathematical programming model for the optimization of heat exchanger networks. The model incorporates rigorous formulation to handle process streams with phase change (condensation or evaporation), and is applied to a case study of an ethylene glycol production plant in Taiwan for minimizing utility consumption. The results show a compromise between steam savings and process feasibility, as well as how the model is modified to reflect practical considerations. In the preliminary analysis, with a substantial potential steam saving of 15,476 kW (28%), the solution involves forbidden matches that pose a hazard to the process and cannot be implemented. In the further analysis without process streams that cause forbidden matches, although the space limitation in the plant renders the best solution infeasible, the compromise solution can achieve a considerable steam saving of up to 8448 kW (91%) and is being evaluated by the plant managers and operators.
Catalytic Hydrothermal Liquefaction of Brachychiton populneus Biomass for the Production of High-Value Bio-Crude
Authors: Eladnani Ikram , Bracciale Maria Paola , Damizia Martina , Mousavi Seyedmohammad , De Filippis Paolo , Lakhmiri Rajae , de Caprariis Benedetta
Published: January 2023

The current study focused on the heterogenous catalytic hydrothermal liquefaction (HTL) of Brachychiton populneus biomass seed, using Ni as hydrogenation catalyst and Fe as active hydrogen producer. The activity of Ni metal and of Ni/Al2O3 in the HTL of seed (BS) and of a mixture of seed and shell (BM) was studied. To establish the best operating process conditions, the influence of variation of temperature and reaction time on the product yields was also examined. The highest bio-crude yields of 57.18% and 48.23% for BS and BM, respectively, were obtained at 330 °C and 10 min of reaction time, in the presence of Ni/Al2O3 as catalyst and Fe as hydrogen donor. Elemental analysis results showed that at these operative conditions, an increase of the higher heating value (HHV) from 25.14 MJ/kg to 38.04 MJ/kg and from 17.71 MJ/kg to 31.72 MJ/kg was obtained for BS and BM biomass, respectively, when the combination of Fe and Ni/Al2O3 was used. Gas chromatography–mass spectrometry (GC-MS) and Fourier transform infrared spectroscopy (FT-IR), used to determine the oils’ chemical compositions, showed that the combined presence of Fe and Ni/Al2O3 favored the hydrodeoxygenation of the fatty acids into hydrocarbons, indeed their amount increased to ≈20% for both biomasses used. These results demonstrate that the obtained bio-crude has the capacity to be a source of synthetic fuels and chemical feedstock.
Review on Digestibility of Aerobic Granular Sludge
Authors: Zaghloul Mohamed S. , Halbas Asmaa M. , Hamza Rania A. , Elbeshbishy Elsayed
Published: January 2023

Full-scale wastewater treatment plants utilizing aerobic granular sludge technology are being built in many countries worldwide. As with all biological wastewater treatment plants, the produced waste biomass must be stabilized to protect the population, wildlife, and the environment. Digestion is usually used to break down the complex organics in the waste sludge; however, the digestibility of aerobic granular sludge still needs to be fully understood compared to the conventional activated sludge. This paper reviews the studies published on the digestibility of waste aerobic granular sludge to date. Studies comparing aerobic granular sludge and activated sludge in terms of composition, properties, and digestibility are highlighted. The impact of biological composition and physical properties on the digestibility of sludge is reviewed in terms of biomethane production and biodegradability. The effect of pre-treatment is also covered. Areas for future research are presented.
Sorption of Phosphate on Douglas Fir Biochar Treated with Magnesium Chloride and Potassium Hydroxide for Soil Amendments
Authors: Arwenyo Beatrice , Navarathna Chanaka , Das Naba Krishna , Hitt Addie , Mlsna Todd
Published: January 2023

With increasing climate variability, a sustainable crop production approach remains an indispensable concern across the globe. In this study, P retention/availability of MgCl2.6H2O/KOH modified Douglas fir biochar was assessed. The MgCl2·6H2O/KOH treated Douglas fir biochar was prepared by sequentially treating Douglas fir biochar with magnesium chloride and potassium hydroxide solutions. The biochar’s surface area, pore volume, morphology, and elemental compositions were determined using BET, SEM, SEM/EDS, and powder X-ray analyzes. Both surface area and pore volume were reduced by more than 97% following modification. Similarly, the morphology and elemental compositions changed after modification. The maximum P adsorbed corresponding to Langmuir–Freundlich model was 41.18 mg g−1. P sorption on biochar soil mixture was pH dependent. More studies are required to establish the field applicability of P-laden MgCl2 ·6H2O/KOH-modified Douglas fir biochar as a soil additive.
Acknowledgment to the Reviewers of Reports in 2022
Authors:   Reports Editorial Office
Published: January 2023

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Bin Picking for Ship-Building Logistics Using Perception and Grasping Systems
Authors: Cordeiro Artur , Souza João Pedro , Costa Carlos M. , Filipe Vítor , Rocha Luís F. , Silva Manuel F.
Published: January 2023

Bin picking is a challenging task involving many research domains within the perception and grasping fields, for which there are no perfect and reliable solutions available that are applicable to a wide range of unstructured and cluttered environments present in industrial factories and logistics centers. This paper contributes with research on the topic of object segmentation in cluttered scenarios, independent of previous object shape knowledge, for textured and textureless objects. In addition, it addresses the demand for extended datasets in deep learning tasks with realistic data. We propose a solution using a Mask R-CNN for 2D object segmentation, trained with real data acquired from a RGB-D sensor and synthetic data generated in Blender, combined with 3D point-cloud segmentation to extract a segmented point cloud belonging to a single object from the bin. Next, it is employed a re-configurable pipeline for 6-DoF object pose estimation, followed by a grasp planner to select a feasible grasp pose. The experimental results show that the object segmentation approach is efficient and accurate in cluttered scenarios with several occlusions. The neural network model was trained with both real and simulated data, enhancing the success rate from the previous classical segmentation, displaying an overall grasping success rate of 87.5%.