bluuebunny/crossref_metadata_2025 huggingface dataset:
Poor Mental Health in Caregivers of Children with Attention-Deficit/Hyperactivity Disorder and Its Relationships with Caregivers’ Difficulties in Managing the Children’s Behaviors and Worsened Psychological Symptoms during the COVID-19 Pandemic
Authors: Tseng Hui-Wen , Tsai Ching-Shu , Chen Yu-Min , Hsiao Ray C. , Chou Fan-Hao , Yen Cheng-Fang
Published: September 2021

The coronavirus disease 2019 (COVID-19) pandemic has thrown out a challenge to caregivers of children with attention-deficit/hyperactivity disorder (ADHD). The present study examined the factors related to the poor general mental health state of the caregivers of children with ADHD during the COVID-19 pandemic, including (1) difficulties of caregivers in asking their child to adopt protective behaviors against COVID-19, (2) difficulties of caregivers in managing the child’s daily performance, and (3) worsened psychological symptoms in children. In total, 161 caregivers completed an online questionnaire to provide data regarding their general mental health state and difficulties in asking their child with ADHD to adopt protective behaviors against COVID-19 and in managing the child’s after-school learning, sleep routine, and internet use, as well as worsened psychological symptoms. The results of multivariate logistic regression analysis demonstrated that caregivers’ difficulties in managing ADHD children’s self-protective behaviors and after-school learning and the children’s worsened emotional symptoms were significantly associated with poor caregiver general mental health state. An intervention that enhances the mental health of caregivers of children with ADHD during the COVID-19 pandemic by addressing their difficulties in managing the children’s behaviors and psychological problems is warranted.
Health Risk Assessments of Selected Trace Elements and Factors Associated with Their Levels in Human Breast Milk from Pretoria, South Africa
Authors: Olowoyo Joshua O. , Macheka Linda R. , Mametja Phiona M.
Published: September 2021

While breast milk is the recommended food for infants up to at least six months, exogenously derived compounds such as trace elements have been widely reported in human milk which may make it become toxic or a source of pollutants to the infants. Numerous short- and long-term health effects have been associated with high body—burdens of trace elements, which are amplified in infants. The current study determined the levels and possible contributing factors of six trace elements in breast milk of nursing mothers from a local hospital in Pretoria. Extraction of trace elements employed a digestion technique using perchloric and nitric acid in a ratio of 1:3, while Inductively Coupled Plasma–Membrane Spectrophotometry was used to identify and quantify their levels in breast milk. Concentrations of Cr and Mn were the highest in breast milk, with values ranging from 0.30 to 5.72 µg/L and 0.23 to 5.13 µg/L, respectively. Levels of Co, As, Pb and Cd ranged from <LOD to 0.2 µg/L, <LOD to 2.29 µg/L, 0.05 to 1.06 µg/L, and 0.004 to 0.005 µg/L, respectively. Levels of Cr, Mn and As were higher than the recommended limits from WHO (World Health Organization) in some milk samples. Dietary assessments showed minimal risk for the infants through breastfeeding at this stage; however, prolonged exposure to other sources of these toxic trace elements may pose a serious health risk for the infants. The nature of employment, infant birth weight, passive smoking and maternal diet were the significant factors noted to contribute to trace metal levels in breast milk.
Psychological Distress of International Students during the COVID-19 Pandemic in China: Multidimensional Effects of External Environment, Individuals’ Behavior, and Their Values
Authors: Xu Tao
Published: September 2021

The COVID-19 epidemic has had a significant impact on society. In particular, it has had a strong impact on college students, including international students. Through an online questionnaire survey, it is found that the psychological distress experienced by international students is the result of a combination of the external environment (including the lockdown measures, social distancing, and social support) and internal factors such as values and behavior. The analysis shows that the new teaching mode and the corresponding changes in learning behavior are significantly associated with the psychological distress brought about by the COVID-19 epidemic. In addition, the influence of international students’ values also plays a significant role in their psychological distress. Collective values are conducive to the alleviation of psychological distress, while individual values have the opposite effect. At the same time, the study also reveals that if there is sufficient social support, isolation (due to lockdown or social distancing early or later on) is not necessarily directly related to psychological distress. However, only formal social support can effectively alleviate psychological distress, while informal social support does not play a similar role. These conclusions have certain policy significance for the prevention of and response to epidemics in other countries.
Father-Teen Talks about Sex and Teens’ Sexual Health: The Role of Direct and Indirect Communication
Authors: Grossman Jennifer M. , DeSouza Lisette M. , Richer Amanda M. , Lynch Alicia D.
Published: September 2021

Family talks about sex can protect against teens’ risky sexual behavior, but most research has focused on the role of mothers. The current study included cross-sectional survey data from 728 adolescents in the 11th and 12th grades (Mage = 17.00, SD = 0.90) in the United States. Structural equation modeling (SEM) was used to assess associations between teens’ direct and indirect talk, defined as less straightforward ways to communicate one’s sexual values, with fathers about sex, and teens’ sexual behaviors. There were no significant direct associations between father-teen talk about sex and teens’ sexual behavior. However, teen gender moderated associations between indirect father-teen communication and teens’ sexual behavior. The results suggest the need to assess indirect talk about sex in studies of family sexuality communication and to further investigate the role of teens’ identities in determining the influence of father-teen talk about sex on teens’ sexual behavior.
Data-Powered Positive Deviance during the SARS-CoV-2 Pandemic—An Ecological Pilot Study of German Districts
Authors: Driesen Joshua , El-Khatib Ziad , Wulkow Niklas , Joblin Mitchell , Vasileva Iskriyana , Glücker Andreas , Kruspel Valentin , Vogel Catherine
Published: September 2021

We introduced the mixed-methods Data-Powered Positive Deviance (DPPD) framework as a potential addition to the set of tools used to search for effective response strategies against the SARS-CoV-2 pandemic. For this purpose, we conducted a DPPD study in the context of the early stages of the German SARS-CoV-2 pandemic. We used a framework of scalable quantitative methods to identify positively deviant German districts that is novel in the scientific literature on DPPD, and subsequently employed qualitative methods to identify factors that might have contributed to their comparatively successful reduction of the forward transmission rate. Our qualitative analysis suggests that quick, proactive, decisive, and flexible/pragmatic actions, the willingness to take risks and deviate from standard procedures, good information flows both in terms of data collection and public communication, alongside the utilization of social network effects were deemed highly important by the interviewed districts. Our study design with its small qualitative sample constitutes an exploratory and illustrative effort and hence does not allow for a clear causal link to be established. Thus, the results cannot necessarily be extrapolated to other districts as is. However, the findings indicate areas for further research to assess these strategies’ effectiveness in a broader study setting. We conclude by stressing DPPD’s strengths regarding replicability, scalability, adaptability, as well as its focus on local solutions, which make it a promising framework to be applied in various contexts, e.g., in the context of the Global South.
A Survey of Patients’ Opinions and Preferences on the Use of E-Prescriptions in Poland
Authors: Wrzosek Natalia , Zimmermann Agnieszka , Balwicki Łukasz
Published: September 2021

E-prescription is already used in many countries, improving the standard of patient care. Officially, from 8 January 2020 e-prescribing has been obligated in Poland. Physicians’ and pharmacists’ opinions on e-prescribing have been widely researched and reported in the literature. In contrast, patients’ perception has, to date, received little attention. For this reason, the aim of this study was to find the features and functionalities of e-prescribing that are desired by the public and influence the positive evaluation of this tool, according to patient opinion. In order to obtain data, a questionnaire was completed by 456 randomly selected adults. The obtained results indicated that only eight people (1.8%) did not know what e-prescription is. Of the remaining 448 individuals, 72.1% prefer e-prescription because it is more convenient for them. Most patients (62.1%) also recognize that e-prescribing makes it easier to purchase medications on behalf of another patient. Based on the study, it can be concluded that e-prescription is well evaluated by Polish patients. A large percentage of respondents were positive about obtaining prescriptions for continued treatment, without a personal doctor visit. Therefore, it is reasonable to maintain the possibility of such contact with a physician. The most popular, and preferred, method of receiving e-prescriptions is via SMS. However, it is necessary to offer different options for obtaining prescriptions, to meet the needs of different populations.
The Impact of COVID-19 on the Preparation for the Tokyo Olympics: A Comprehensive Performance Assessment of Top Swimmers
Authors: Csulak Emese , Petrov Árpád , Kováts Tímea , Tokodi Márton , Lakatos Bálint , Kovács Attila , Staub Levente , Suhai Ferenc Imre , Szabó Erzsébet Liliána , Dohy Zsófia , Vágó Hajnalka , Becker Dávid , Müller Veronika , Sydó Nóra , Merkely Béla
Published: September 2021

Background: The Olympic preparation of athletes has been highly influenced by COVID and post-COVID syndrome. As the complex screening of athletes is essential for safe and successful sports, we aimed to repeat the 2019-year sports cardiology screening of the Olympic Swim Team before the Olympics and to compare the results of COVID and non-COVID athletes. Methods: Patient history, electrocardiogram, laboratory tests, body composition analysis, echocardiography, cardiopulmonary exercise test (CPET) were performed. We used time-ranking points to compare swimming performance. Results: From April 2019, we examined 46 elite swimmers (24 ± 4 years). Fourteen swimmers had COVID infection; all cases were mild. During CPET there was no difference in the performance of COVID (male: VO2 max 55 ± 4 vs. 56.5 ± 5 mL/kg/min, p = 0.53; female: VO2 max 54.6 ± 4 vs. 56 ± 5.5 mL/kg/min, p = 0.86) vs. non-COVID athletes (male VO2 max 56.7 ± 5 vs. 55.5 ± 4.5 mL/kg/min, p = 0.50; female 49.6 ± 3 vs. 50.7 ± 2.6 mL/kg/min, p = 0.47) between 2019 and 2021. When comparing the time results of the National Championships, 54.8% of the athletes showed an improvement (p = 0.75). Conclusions: COVID infection with short-term detraining did not affect the performance of well-trained swimmers. According to our results, the COVID pandemic did not impair the effectiveness of the preparation for the Tokyo Olympics.
Mechanistic Insights into Axenfeld–Rieger Syndrome from Zebrafish foxc1 and pitx2 Mutants
Authors: French Curtis R.
Published: September 2021

Axenfeld–Rieger syndrome (ARS) encompasses a group of developmental disorders that affect the anterior segment of the eye, as well as systemic developmental defects in some patients. Malformation of the ocular anterior segment often leads to secondary glaucoma, while some patients also present with cardiovascular malformations, craniofacial and dental abnormalities and additional periumbilical skin. Genes that encode two transcription factors, FOXC1 and PITX2, account for almost half of known cases, while the genetic lesions in the remaining cases remain unresolved. Given the genetic similarity between zebrafish and humans, as well as robust antisense inhibition and gene editing technologies available for use in these animals, loss of function zebrafish models for ARS have been created and shed light on the mechanism(s) whereby mutations in these two transcription factors cause such a wide array of developmental phenotypes. This review summarizes the published phenotypes in zebrafish foxc1 and pitx2 loss of function models and discusses possible mechanisms that may be used to target pharmaceutical development and therapeutic interventions.
Novel Concepts of Glioblastoma Therapy Concerning Its Heterogeneity
Authors: Hutóczki Gábor , Virga József , Birkó Zsuzsanna , Klekner Almos
Published: September 2021

Although treatment outcomes of glioblastoma, the most malignant central nervous system (CNS) tumor, has improved in the past decades, it is still incurable, and survival has only slightly improved. Advances in molecular biology and genetics have completely transformed our understanding of glioblastoma. Multiple classifications and different diagnostic methods were made according to novel molecular markers. Discovering tumor heterogeneity only partially explains the ineffectiveness of current anti-proliferative therapies. Dynamic heterogeneity secures resistance to combined oncotherapy. As tumor growth proceeds, new therapy-resistant sub clones emerge. Liquid biopsy is a new and promising diagnostic tool that can step up with the dynamic genetic change. Getting a ’real-time’ picture of a specific tumor, anti-invasion and multi-target treatment can be designed. During invasion to the peri-tumoral brain tissue, glioma cells interact with the extracellular matrix components. The expressional levels of these matrix molecules give a characteristic pattern, the invasion spectrum, which possess vast diagnostical, predictive and prognostic information. It is a huge leap forward combating tumor heterogeneity and searching for novel therapies. Using the invasion spectrum of a tumor sample is a novel tool to distinguish between histological subtypes, specifying the tumor grades or different prognostic groups. Moreover, new therapeutic methods and their combinations are under trial. These are crucial steps towards personalized oncotherapy.
The CXC Chemokine Receptors in Four-Eyed Sleeper (Bostrychus sinensis) and Their Involvement in Responding to Skin Injury
Authors: Dong Mengdan , Zhang Hong , Mo Chengyu , Li Wenjing , Zhang Wanwan , Jia Kuntong , Liu Wei , Yi Meisheng
Published: September 2021

CXC Chemokine signaling plays an important role in wound healing. The four-eyed sleeper (Bostrychus sinensis) is a commercially important marine fish, which is prone to suffer skin ulceration at high temperature seasons, leading to mass mortality of fish in aquaculture farms. The genetic background related to skin ulceration and wound healing has remained unknown in this fish. Herein, we identified 10 differentially expressed Bostrychus sinensis CXC chemokine receptors (BsCXCRs) in skin ulcerated fish by de novo transcriptome sequencing. The transcripts of these BsCXCRs were classified in seven types, including BsCXCR1a/1b, BsCXCR2, BsCXCR3a1/3a2, BsCXCR4a/4b, and BsCXCR5-7, and BsCXCR6 was the first CXCR6 homologue experimentally identified in teleost fish. These BsCXCRs were further characterized in gene and protein structures, as well as phylogenetics, and the results revealed that BsCXCRs have expanded to divergent homologues. Our results showed that, in healthy fish, the BsCXCR transcripts was mainly distributed in the muscle and immune related organs, and that BsCXCR1a/1b proteins located in the cytomembrane, BsCXCR4a/4b/5/6 in the cytomembrane and perinuclear region, and BsCXCR3a1/3a2/7 in the cytomembrane, perinuclear region, and nuclear membrane, respectively. In skin injured fish, the transcripts of all BsCXCRs were transiently increased within one hour after injury, suggesting the involvement of BsCXCRs into the early inflammatory response to skin injury in the four-eyed sleeper. These results are valuable for understanding the evolutionary events of fish CXCR genes and provide insights into the roles of CXCR family in fish skin injury.
Exploiting B Cell Transfer for Cancer Therapy: Engineered B Cells to Eradicate Tumors
Authors: Page Audrey , Hubert Julie , Fusil Floriane , Cosset François-Loïc
Published: September 2021

Nowadays, cancers still represent a significant health burden, accounting for around 10 million deaths per year, due to ageing populations and inefficient treatments for some refractory cancers. Immunotherapy strategies that modulate the patient’s immune system have emerged as good treatment options. Among them, the adoptive transfer of B cells selected ex vivo showed promising results, with a reduction in tumor growth in several cancer mouse models, often associated with antitumoral immune responses. Aside from the benefits of their intrinsic properties, including antigen presentation, antibody secretion, homing and long-term persistence, B cells can be modified prior to reinfusion to increase their therapeutic role. For instance, B cells have been modified mainly to boost their immuno-stimulatory activation potential by forcing the expression of costimulatory ligands using defined culture conditions or gene insertion. Moreover, tumor-specific antigen presentation by infused B cells has been increased by ex vivo antigen loading (peptides, RNA, DNA, virus) or by the sorting/ engineering of B cells with a B cell receptor specific to tumor antigens. Editing of the BCR also rewires B cell specificity toward tumor antigens, and may trigger, upon antigen recognition, the secretion of antitumor antibodies by differentiated plasma cells that can then be recognized by other immune components or cells involved in tumor clearance by antibody-dependent cell cytotoxicity or complement-dependent cytotoxicity for example. With the expansion of gene editing methodologies, new strategies to reprogram immune cells with whole synthetic circuits are being explored: modified B cells can sense disease-specific biomarkers and, in response, trigger the expression of therapeutic molecules, such as molecules that counteract the tumoral immunosuppressive microenvironment. Such strategies remain in their infancy for implementation in B cells, but are likely to expand in the coming years.
Melatonin and Phytomelatonin: Chemistry, Biosynthesis, Metabolism, Distribution and Bioactivity in Plants and Animals—An Overview
Authors: Mannino Giuseppe , Pernici Carlo , Serio Graziella , Gentile Carla , Bertea Cinzia M.
Published: September 2021

Melatonin is a ubiquitous indolamine, largely investigated for its key role in the regulation of several physiological processes in both animals and plants. In the last century, it was reported that this molecule may be produced in high concentrations by several species belonging to the plant kingdom and stored in specialized tissues. In this review, the main information related to the chemistry of melatonin and its metabolism has been summarized. Furthermore, the biosynthetic pathway characteristics of animal and plant cells have been compared, and the main differences between the two systems highlighted. Additionally, in order to investigate the distribution of this indolamine in the plant kingdom, distribution cluster analysis was performed using a database composed by 47 previously published articles reporting the content of melatonin in different plant families, species and tissues. Finally, the potential pharmacological and biostimulant benefits derived from the administration of exogenous melatonin on animals or plants via the intake of dietary supplements or the application of biostimulant formulation have been largely discussed.
Long-Term Clinical and Multimodal Imaging Findings in Patients with Disseminated Mycobacterium Chimaera Infection
Authors: Zweifel Sandrine Anne , Wiest Maximilian Robert Justus , Toro Mario Damiano , Hasler Pascal , Maloca Peter , Hasse Barbara , Khanna Nina , Rejdak Robert
Published: September 2021

Background: To analyze long-term ophthalmic clinical and multimodal imaging findings of disseminated Mycobacterium (M.) chimaera infection after cardiothoracic surgery among the Swiss Cohort. Methods: Systemic and multimodal ophthalmic imaging and clinical findings including rate of recurrence were reviewed and correlated to a previously proposed classification system of choroidal lesions and classification of ocular disease. Main Outcomes Measures: long-term clinical and multimodal ocular imaging findings of M. chimaera. Results: Twelve patients suffering from systemic infection from M. chimaera were included. Mean age at the first ophthalmic examination was 59 years (range from 48 to 66 years). Mean duration of the follow-up was 22.63 ± 17.8 months. All patients presented with bilateral chorioretinal lesions at baseline; 5 patients had additional signs, including optic disc swelling (2), choroidal neovascularization (1), retinal neovascularization (1) and cilioretinal vascular occlusion (1). Four recurrence events after discontinuation or adjustment of the antibiotic treatment were observed. Progressive choroiditis was seen in 5 patients under treatment, 4 of them deceased. Conclusions: Expertise from ophthalmologists is not only relevant but also critical for the assessment of the adverse drug effect of antimycobacterial treatment along with monitoring therapeutic response and identifying recurrences.
Durability of Transcatheter Heart Valves: Standardized Definitions and Available Data
Authors: Richter Ines , Thiele Holger , Abdel-Wahab Mohamed
Published: September 2021

Transcatheter aortic valve replacement is a well-established alternative to surgical aortic valve replacement in high-risk patients with severe symptomatic aortic stenosis. Currently, this technique is shifting towards younger patient groups with intermediate- and low-risk profile, which raises the question about long-term durability. Despite acceptable results up to 5 years, little is currently known about valve performance beyond 5 years. Since valve deterioration, thrombosis and endocarditis seem to be the main factors affecting valve durability, precise and widely accepted definitions of these parameters were stated by the European Association of Percutaneous Cardiovascular Interventions (EAPCI) in 2017, followed by the Valve in Valve International Data (VIVID) group definitions in 2018 and the Valve Academic Research Consortium 3 (VARC-3) definitions in 2021. Until the introduction of these definitions, interstudy comparisons were difficult due to missing uniformity. Since the release of these recommendations, an increasing number of studies have reported their data on long-term durability using these new criteria. The aim of the present article is to discuss the current definitions on bioprosthetic valve durability, and to summarize the available data on long-term durability of transcatheter aortic valves.
Auricular Acupressure Combined with Self-Help Intervention for Treating Chronic Tinnitus: A Longitudinal Observational Study
Authors: Schlee Winfried , Simoes Jorge , Pryss Rüdiger
Published: September 2021

Tinnitus is a phantom sound perception in the ears or head and can arise from many different medical disorders. Currently, there is no standard treatment for tinnitus that reliably reduces tinnitus. Individual patients reported that acupressure at various points around the ear can help to reduce tinnitus, which was investigated here. With this longitudinal observational study, we report a systematic evaluation of auricular acupressure on 39 tinnitus sufferers, combined with a self-help smartphone app. The participants were asked to report on tinnitus, stress, mood, neck, and jaw muscle tensions twice a day using an ecological momentary assessment study design for six weeks. On average, 123.6 questionnaires per person were provided and used for statistical analysis. The treatment responses of the participants were heterogeneous. On average, we observed significant negative trends for tinnitus loudness (Cohen’s d effect size: −0.861), tinnitus distress (d = −0.478), stress (d = −0.675), and tensions in the neck muscles (d = −0.356). Comparison with a matched control group revealed significant improvements for tinnitus loudness (p = 0.027) and self-reported stress level (p = 0.003). The positive results of the observational study motivate further research including a randomized clinical trial and long-term assessment of the clinical improvement.
The new state program for the restoration of abandoned lands and the development of the reclamation complex is a necessary step to ensure food security
Authors: Lipski S.A.
Published: September 2021

A necessary condition for food security is the rational use of lands suitable for agriculture. The article considers the legislative and strategic measures implemented at the present time and in the recent past to involve abandoned lands in the economic turnover and to develop the land reclamation complex.
The structure of the sowing areas of crops in the Non-chernozem region
Authors: Polunin G.A. , Alakoz V.V.
Published: September 2021

The article provides a current regional specialization of agricultural production in the subjects of the Non-chernozem economic zone of the country and its socio-economic features happened by 2016. The special attention is paid to grain cultures, dairy and meat cattle breeding, pig breeding and poultry farming. It is predicted that dairy cattle, which ensures the employment of a significant number of workers in agricultural organizations and farms, remain a basic agricultural activity in rural life of Non-chernozem region, maintaining the productivity of cold regions. There are seven such regions having more or less favorable territories for agricultural production. It seems possible to cultivate full range of crops there. The calculation of the size of the sowing areas per one cattle head in the subjects of Nonchernozem region are considered in this paper. It has been established that the structure of sowing areas in agricultural organizations of the studied regions does not have significant differences compared to peasant farms. The exception is potatoes and vegetables, sowing areas of which are significantly higher in small forms of land use. With a low level of mechanization of agricultural production in small forms of management, (with the exception of few cultivated crops), the growth of production does not lead to increase of effectiveness. In the medium term, according to the authors estimation, the existing practice of concentrating the agricultural production in the territories with the most favorable agro-climatic, soil conditions and favorable position regarding consumer markets will be preserved.
Some problems of land inheritance
Authors: Borisova-Zharova V.G.
Published: September 2021

The article discusses common issues and frequently encountered problems in land inheritance. The author investigates the Russian civil and land laws, analyzes a number of reasons causing disagreement among legal scientists and underlines the need to comply with land and hereditary law. In addition, the author pays an attention to the features of land as an object of civil legal relations, affecting the transfer of ownership or the right of lifetime inheritable possession.
Optimization of agricultural land use taking into account behavior of soils with different terms of agricultural use
Authors: Kovaleva E.V. , Akinchin A.V. , Vagurin I. Y. , Kuzmina O.S.
Published: September 2021

The influence of time of agricultural development on soil behavior was investigated in Belgorod region by example of two key parcels corresponding to broad-forest and meadowsteppe landscapes of forest steppe. It is important to maintain soil agroecological potential and productivity in agroecosystems, having influence on the development of farming systems. The authors identified the following groups of anthropogenic factors affecting soil fertility after long-term agricultural using: mechanical (pressure on the soil and its processing by agricultural machinery, creation of micro- and nano- reliefs); organizational-territorial (various forest belts); chemical (fertilizers introduced, albeit in small quantities, but affecting the microecosystem of the parcels).
Development of a system for assessing the rationality of use of urban lands in the conditions of the renovation of the residential areas
Authors: Sevostiyanov A.V. , Pastukhov V. E.
Published: September 2021

The article discusses the methodology for assessing the rationality of land use in urban areas in the conditions of the renovation of the residential area. The criteria influencing the rationality of the territory use are analyzed. A step-by-step assessment of the territory using the proposed rationality criteria is done.
Transformation of hay and pasture lands to hazelnut gardens in the Irfsky district of Alania
Authors: Gadzhiev R.K. , Kuchiev S.E. , Rogova T.A.
Published: September 2021

The article deals with the transformation of unproductive hay and pasture lands to intensively used perennial plantings of hazelnuts. The authors evaluate the productivity of the transformed lands.
A hectare of development and opportunities
Authors: Shelomentsev V.N.
Published: September 2021

The article analyzes the regulatory and legal framework for the implementation of the program providing citizens with land plots from the state or municipal ownership and located in the territories of the subjects of the Russian Federation, as well as in the Far Eastern Federal District, or included in the program "Socio-economic development of the Arctic zone of the Russian Federation".
ESG-Real estate evaluation and taxation
Authors: Korostelev S.P.
Published: September 2021

The article analyzes the current conditions of professional real estate evaluation in the Russian Federation and draws a conclusion — this sphere is in crisis. The authors noted an appearance of a new type of real estate evaluation related to their "environmentalness" ("green evaluators"). Particular attention is paid to the recent events at the federal level related to the climate agenda and caused by the introduction by the European Union of a border carbon tax. Since real estate objects are one of the main sources of greenhouse emissions, it becomes necessary to take into account the factors of climatic and environmental assessment of real estate, including those for taxation. So, a new direction of economic measurements is being formed — ESG (environmental, social, and governance) evaluation. Taking into account the mistakes made in the evaluation methodology, the authors give the recommendations for the creation of an ESG-evaluation methodology based on the post-neoclassical paradigm and qualimetric methods.
The trends of the Russian system of accounting and registration of rights to real estate objects. Part I
Authors: Osennyaya A.V. , Bystrova A.V. , Khakhuck B.A. , Osennyaya Е.А.
Published: September 2021

The article contains the prerequisites and main stages of the formation of the Russian system of accounting and registration of rights to real estate objects. It is noted that the beginning of the transformation process was the Law of the RSFSR "Land reform", adopted in November 23, 1990. The authors considered the main changes in the system, reviewed the characteristics of the stages, and made the conclusions about the implementation of the system of the Unified state register of real estate objects in the country.
Taraxacum dooguei and T. dudmanianum (Asteraceae) - two new species from Britain and Ireland
Authors: Richards A. J.
Published: September 2021

Two new species are Taraxacum are described: T. dooguei A.J. Richards, a section Celtica  species from Ireland related to T. pietii-oosterveldii, and T. dudmanianum A.J. Richards, a section Taraxacum species from Britain and Ireland previously incorrectly recorded as T. aberrans. Notes are given on their ecology and distributions.
Three new species of Alchemilla (Rosaceae) from northern Britain
Authors: Lynes Mark
Published: September 2021

Three new species of Alchemilla are described, two from the Northern England and a third from the highlands of Scotland. Alchemilla falsadenta and Alchemilla mebii (Rosaceae) are described from the Yorkshire Dales. Both belong to the Series Vulgares Buser, Subseries Subglabrae H. Lindberg, although the latter could conceivably be placed in Subseries Hirsutae H. Lindberg. Alchemilla neomanifesta of the Series Vulgares, Subseries Hirsutae is described from Ben Lawers National Nature Reserve.
MORAL CULTURE: PHILOSOPHICAL-PEDAGOGICAL CONTEXT
Authors: Kapitan Natalia
Published: September 2021

The modern state of the problem of forming the moral culture in humanistics is considered. The analysis of research of the 20th-21st centuries concerning the problem in such areas of science as philosophy, ethics, psychology, pedagogy is given. Natural ways to study the essence of moral culture in contemporary philosophy are found. It is revealed that the starting point for the philosophic analysis of moral culture in the mid-80s of the 20th century is the correlation of the freedom of society and freedom of personality. The role of moral culture in the system of human communication is found, that is most clearly expressed in the philosophical hermeneutics. The achievements in the study of contemporary issues of moral culture belonging   to   religious   philosophy   are   outlined   (works   of   H. Vashchenko, A. Vyshnevskyi, L. Moskaliova, I. Ohiienko, Ya. Yarema, etc.). The analysis of these problems is made in the works of the representatives of ethical thought, namely by L. Arkhanhelskii, V.Bibler, G. Vasianovych A. Guseinov, I. Ziaziun, L. Moskaliova, L. Horuzhy and others. It has been found that the psychological sphere representatives unanimously believe that the moral culture is an integrative social, personal, spiritual phenomenon that requires a fundamental methodological research, and the main requirement for such studies should be comprehensive, humanistic character, which is appropriate not only for the present but also for the future. The valuable researches of the 21st century in the sphere of moral culture in pedagogy are outlined. Particular attention is paid to theses studies that reveal the specific expression of moral culture in different spheres of an individual’s life.
FORMATION OF MORALITY OF CHILDREN AND YOUTH BY PROTECTION FROM HARMFUL INFORMATION
Authors: Alyosha Olexandra
Published: September 2021

The article considers the Internet environment and mass media as powerful factors in the formation of socio-cultural norms and values. Particular attention is paid to content that has a potential impact on the moral development of personality in the course of its socialization. The experience of state and public regulation in the field of protecting children from harmful information is generalized. It is proved that the protection of children and young people is impossible without identifying concrete ways and means of introducing humanitarian expertise in the information sphere. It is determined that the purpose of public regulation of the information space is to protect children from the influence to which they are not ready due to their level of development, as well as creating a favorable environment for gradual maturation through the formation of clear value orientations of the individual.It is determined that the purpose of public regulation of the information space is to protect children from the influence to which they are not ready due to their level of development, as well as creating a favorable environment for gradual maturation through the formation of clear value orientations of the individual. The most promising direction is the psychological support of the development of personal information security skills for children of different ages and their parents: the ability to recognize false information, to identify manipulative influence, to develop the ability to critically understand perceived information, to withstand emotional and negative informational factors.Parents can act in a variety of ways to ensure the information security of children: through deliberate and selective use of the media, stimulating the critical attitude of children to information from various sources, and restricting access to potentially harmful content. But the main pledge of information security is the trust relationship between the child and the parents, the attitude of the elders as an authoritative source of moral norms and values. After all, it is the parents who must explain to the child what is good and what is bad, instill moral qualities. There is also an opposite view – fears about the negative impact of television, the Internet and other information resources are too exaggerated.
PROFESSIONAL ETHICS IN LINGUA-CULTURAL DIMENSIONS: AMERICAN EXPERIENCE
Authors: Semenoh Olena , Kravchenko Olena
Published: September 2021

The article outlines the concepts "nurse", "professional ethics of nurses." The professional ethics of nurses has been defined as a component of medical ethics which studies moral consciousness, moral and ethical aspects of professional activity, moral principles and values that regulate the moral relationship between s nurse and s patient, the patient's family, other members of the medical community and community. The analysis of foreign and Ukrainian experience of formation of nurses’ professional ethics gives grounds to characterize the quality as a set of interrelated cognitive, praxeological, communicative components; their presence allows to interact productively with the professional and social environment on the basis of professionally important ethical knowledge, skills, professional important qualities that are aimed at the effective organization of the medical-preventive process and the solution of professional tasks. The content of the professional ethics of a future nurse consists of ethical categories and professionally important ethical qualities such as: professional duty, responsibility, dignity, conscience, honor, respect, mercy, empathy, tolerance.The peculiarities of educational programs of future licensed younger nurses training (LPN) in the United States aimed at the formation of professional ethics have been outlined. A review of the linguistic- cultural aspect of the formation of nurses’ professional ethics at American higher education institutions has been conducted. The experience of classes on "Nursing Ethics", "Foreign Language" at Cherkasy Medical Academy has been presented; they are aimed at understanding the world of the profession, the culture of communication in medical community, ethical behavior, moral relations, prevention of conflict situations, and provision of psychological support.
METHODS AND TECHNIQUES FOR ORGANIZATION OF MULTICULTURAL EDUCATION OF FUTURE TEACHER
Authors: Sultanova Leila
Published: September 2021

The important characteristic of the future teacher in the higher pedagogical educational institution is theoretical knowledge of multicultural education and practical skills necessary for the successful professional activity. Therefore, the efficiency of the cognition process when studying disciplines aimed at multicultural education of the future teacher in the higher educational institution is essential and depends entirely on the cognitive activity of the student. The achievement of this goal depends not only on the content of studies but also on the fact what methods and techniques of teaching are chosen for the organization of the process of multicultural education.We have analyzed most common classifications of teaching methods. We have found that the classification proposed by Yu. K. Babanskiy is appropriate in the choice of teaching methods for the discipline "Multicultural Education of the Future Teacher in the Higher Education Institution". Accordingly, we have selected and characterized the following three groups of methods: methods for the organization and conducting of the educational and cognitive activity; methods for the stimulation and motivation of the educational and cognitive activity; methods for control and self-control of the educational and cognitive activity. In addition, we have worked on the training in the development of critical thinking that involves the use of such methods and techniques as: the method of cluster analysis; the method of the use of questions which helps to develop critical thinking («Bloom's Camomile»); techniques for the analysis of information quality (separation of judgments, assumptions and assertions; use of technology of effective reading (INSERT), and the like.
Differentiation of Juxtaglomerular Apparatus Cells in Developing Nephrons in BALB /c Type Mouse Embryos
Authors: GÜRCÜ Beyhan , KARAÇALI Sabire
Published: September 2021

Objective: This study examined the development of nephrons and the differentiation of juxtaglomerular apparatus (JGA) cells in BALB/c type mouse embryos. Thick and thin epon sections were investigated by light microscopy (LM) and transmission electron microscopy (TEM) respectively.

Materials and Methods: Nephron development is completed by passing through the nephrogenic vesicles in the respected stages of comma shape body, S-shape body, precapillary, immature glomerular, and mature glomerular stage. JGA is distinguished in the mature glomerular stage of nephron development at LM level. According to TEM observations, signs of differentiation of juxtaglomerular (JG) cells and macula densa (MD) cells forming JGA are seen earlier, in precapillary stage. In developed Golgi fields that characterize JG cells, large number of electron lucent small vesicles and small number of electron dense large renin granules are seen in the precapillary stage. In the mature glomerulus, the number of electron dense large granules increases in JG cells. The differentiation of MD cells is indicated by the formation of primary cilia on their apical faces in precapillary stage. Deep membrane folds are formed in the basal and lateral faces of MD cells in the mature glomerular stage. There are many numbers of large mitochondria in these regions.

Results: JG and MD cells, which play an absolute role in the regulation of the renin-angiotensin system are differentiated in precapillary stage before completion of nephron development and formation of blood vessels.

Conclusion: Such early differentiation of JGA cells suggests that the renin-angiotensin system is important both in the development of the kidney and in the total development of embryo.
Hepatosellüler Karsinomda Klinik ve Prognostik Özelliklerin Değerlendirilmesi: Tek Merkez Deneyimi
Authors: ERDOĞAN Atike Pinar , EKİNCİ Ferhat , ÖZVEREN Ahmet , ÇELİK Cumali , ATEŞ Gonca Akdere , AKAY Seval , DİRİCAN Ahmet
Published: September 2021

Giriş ve Amaç: Hepatoselüler karsinom (HCC), kanserin yaygın bir nedenidir ve çoğu HCC hastasında altta yatan siroz vardır. Retrospektif olarak kliniğimizde takipli HCC'li hastalarını karakterize etmeyi, sağkalımı araştırmayı ve sağkalım için öngörücü faktörleri belirlemeyi amaçladık.

Gereç ve Yöntemler: Manisa Celal Bayar Üniversitesi Tıbbi Onkoloji Polikliniğinde 2014-2019 yılları arasında HCC teşhisi konan tüm hastalar geriye dönük olarak çalışmaya kaydedildi. Genel sağkalım Kaplan -Meier yöntemi kullanılarak hesaplandı. Sağkalım için öngördürücü faktörleri belirlemek için çok değişkenli Cox regresyon analizi yapıldı.

Bulgular: Kliniğimizde takipli 40 HCC hastasının medyan tanı yaşı 66 olup %90’ı erkektir. Hepatit B virüs (HBV) enfeksiyonu en sık etyolojik sebeptir. C-Reaktif Protein (CRP) seviyesi daha yüksek olan hastaların sağkalım sürelerinin daha kısa olduğu görülmüştür. AFP düzeyi ile sağkalım arasında anlamlı korelasyon izlenmemiştir.

Sonuç: Bölgemizde HBV’ye bağlı HCC’nin daha sık görüldüğü saptanmıştır. Hedefe yönelik tedavilerin umut vadettiği ve bu yönde prediktif belirteçlere ihtiyaç duyulduğu düşünülmektedir.
INTERRELATION OF microRNAS AND TRANSPOSONS IN AGING AND CARCINOGENESIS
Authors: Мустафин Р.Н.
Published: September 2021

Активация мобильных генетических элементов играет роль в канцерогенезе и физиологическом старении человека, которое ассоциировано с развитием злокачественных новообразований. В данной статье представлены результаты анализа данных о наличии единых эпигенетических изменений при старении и канцерогенезе, обусловленных динамикой экспрессии происходящих от транспозонов микроРНК. Было выявлено, что при старении нарушается экспрессия происходящей от транспозонов 21 специфической микроРНК, уровень которых меняется также при злокачественных новообразованиях. Ранее подобных свидетельств о взаимосвязи механизмов старения и канцерогенеза на эпигенетическом уровне не было представлено. Полученные результаты позволяют предположить, что одним из ключевых механизмов старения является дисбаланс в запрограммированной активации мобильных генетических элементов, что отражается на изменении эпигенетической регуляции организма и приводит к повышенному риску развития рака. Так как прекурсоры микроРНК могут транслироваться с образованием функциональных молекул, применяемые в геронтологии пептиды могут быть рассмотрены как потенциальные противоопухолевые препараты.

Dysregulation of transposable elements plays a key role in human carcinogenesis. Physiological aging in humans is also caused by deregulation of transposons. Moreover, aging is associated with the development of cancer. We presented the results of an analysis of data on the presence of common epigenetic changes during aging and carcinogenesis, associated with changes in the expression of microRNAs derived from transposons. We found that aging is characterized by changes in the expression of 21 specific transposon-derived microRNAs associated with the development of malignant neoplasms. Before us, evidence similar to ours on the relationship between the mechanisms of aging and carcinogenesis at the epigenetic level has not been presented. We hypothesized that one of the key mechanisms of aging is an imbalance in the programmed activation of mobile genetic elements, which is reflected in changes in the body’s epigenetic regulation and leads to an increased risk of cancer. Since miRNA precursors can be translated with the formation of functional molecules, peptides used in gerontology can be considered as potential anticancer drugs.