bluuebunny/crossref_metadata_2025 huggingface dataset:
Immunoinformatic design of a COVID-19 subunit vaccine using entire structural immunogenic epitopes of SARS-CoV-2
Authors: Behmard Esmaeil , Soleymani Bijan , Najafi Ali , Barzegari Ebrahim
Published: May 2020

Coronavirus disease-19 (COVID-19) is an acute resolved disease, with estimated 3.4% case fatality rate. Due to insufficient data and short onset time of the disease, researchers have to change the strategy against its associated virus, SARS-CoV-2. One of these strategies is the use of computational methods in the field of drug and vaccine design, which can greatly reduce the time and cost of the therapeutic or immunogenic development projects. In this study, we employed various immunoinformatics tools to design a multi-epitope vaccine polypeptide with the highest potential for activating the human immune system against SARS-CoV-2. The initial epitope set was extracted from the whole set of viral structural proteins. Their potential non-toxic and non-allergenic T-cell and B-cell binding and cytokine inducing epitopes were then identified through a priori immunoinformatic prediction. Selected epitopes were bonded to each other with appropriate links. A suitable adjuvant was added to the N-terminus of the vaccine polypeptide sequence to increase its immunogenicity. Molecular modelling of the 3D structure of the vaccine polypeptide, docking, molecular dynamics simulations and free energy calculations confirmed that the designed vaccine had high affinity for Toll-like receptor 3 binding, and that the vaccine-receptor complex was highly stable. Therefore, the designed polypeptide is promising for antigenicity and inducing an effective and safe immune response against SARS-CoV-2 inside the human body.
A RESILIÇÃO UNILATERAL NO CONTRATO DE GESTAÇÃO POR SUBSTITUIÇÃO
Authors: RUZZI Mariana , BERTONI Rosângela Aparecida Vilaça
Published: May 2020

Este trabalho teve por objetivo analisar a importância do desenvolvimento de regulamentação sobre a gravidez por substituição no ordenamento jurídico brasileiro, bem como a aplicação das regulamentações já existentes, e seus reflexos práticos através de aspectos dogmáticos relativos à gravidez por substituição, resoluções de cunho ético e projetos de leis. O presente trabalho estudou a relação jurídica que advém da técnica de reprodução assistida conhecida como gravidez por substituição através do direito comparado, utilizando-se da legislação e do contrato existentes em Portugal, para desta forma comprovar a importância de regulamentar através da legislação brasileira esta prática e analisar os casos de resilição unilateral no Brasil com base na legislação vigente e nas Resoluções do Conselho Federal de Medicina.
VINGANÇA PORNOGRÁFICA COMO UMA DAS FORMAS DE VIOLÊNCIA DOMÉSTICA E FAMILIAR CONTRA A MULHER
Authors: PINTO Marcela Ricarda Costa
Published: May 2020

O objetivo geral do presente trabalho é analisar o histórico de violência contra a mulher desde a construção sociocultural brasileira até os tempos atuais e trazer uma abordagem jurídica e político-sociológica à respeito de um tema cada vez mais presente no dia a dia dos lares brasileiros e que está gerando diversas discussões sobre a necessidade ou não de uma lei específica para esse fim. O presente estudo procura investigar a prática do chamado pornografia de vingança, que consisti na divulgação indevida de imagens/vídeos que foram registrados com ou sem o consentimento do ofendido, na maioria dos casos as vítimas são mulheres e os responsáveis pela são ex-cônjuges.
A INVESTIGAÇÃO CRIMINAL DEFENSIVA SOB O PRISMA DO GARANTISMO PENAL
Authors: HALLAK Pedro Avalos , VOLPE FILHO Clóvis Alberto
Published: May 2020

O presente trabalho inicialmente introduzirá ao leitor a teoria do garantismo penal, cunhada por Ferrajoli com o fundamento de limitar o poder estatal e diminuir os abusos cometidos no exercício da pretensão punitiva. Em um segundo momento, será abordado o tema da investigação preliminar no processo penal, com foco voltado para o modelo adotado no Brasil, qual seja, o inquérito policial e suas peculiaridades. Ao final, o objetivo será concluir sobre a importância ou não de se inserir a investigação criminal defensiva no ordenamento jurídico brasileiro, tendo por base a efetivação dos direitos e garantias individuais assegurados pela Constituição Federal. A metodologia utilizada será majoritariamente qualitativa, através de pesquisas bibliográficas e documentais, especialmente em doutrinas, artigos científicos e monografias de pesquisadores do processo penal.
A REALIDADE CARCERÁRIA BRASILEIRA E O PAPEL DAS APACS COMO VIAS DE RESSOCIALIZAÇÃO
Authors: SOUZA Milena Ivan de
Published: May 2020

Por motivos históricos, econômicos, teóricos e sociais, o atual sistema penitenciário brasileiro enfrenta uma séria crise de funcionamento (resultado, dentre outros fatores, de superlotação, rebeliões e falta de higiene básica). A função ressocializadora desse sistema, amparada por tratados internacionais bem como por leis nacionais, principalmente a Lei de Execução Penal, é raramente alcançada pelos presídios comuns e, com isto, toda a sociedade padece de uma constante insegurança social e de aumento da violência nas ruas. A proposta da pesquisa é demonstrar o distanciamento entre o sistema ideal de prisões – caso fossem respeitados os parâmetros legais e constitucionais – da realidade em que se inserem. Em meio a esse cenário de caos e violação sistemática de direitos humanos, em 1972 surgiu um modelo novo de presídios, elaborado por Mário Ottoboni, chamado de Associação de Proteção e Assistência aos Condenados (APAC), que se propôs a trabalhar com apenados, lá chamados de recuperandos, com suas famílias e com suas comunidades de forma humana e respeitando suas dignidades, e, como resultado, obtiveram números satisfatórios, quando comparados com o sistema comum, que levam ao questionamento da suficiência do cumprimento da pena para a ressocialização do indivíduo e a crença ser esta uma via alternativa para a amenização dos danos e dos problemas que agravam o cenário dos presídios brasileiros.
Polymeric Nanoparticles for Brain Drug Delivery - A Review
Authors: Raman Subashini , Mahmood Syed , Hilles Ayah R. , Javed Md Noushad , Azmana Motia , Al-Japairai Khater Ahmed Saeed
Published: May 2020

Background:

Blood-brain barrier (BBB) plays a most hindering role in drug delivery to the brain. Recent
research comes out with the nanoparticles approach, is continuously working towards improving the delivery to the
brain. Currently, polymeric nanoparticle is extensively involved in many therapies for spatial and temporal targeted
areas delivery.

Methods:

We did a non-systematic review, and the literature was searched in Google, Science Direct and PubMed. An
overview is provided for the formulation of polymeric nanoparticles using different methods, effect of surface modification
on the nanoparticle properties with types of polymeric nanoparticles and preparation methods. An account of different
nanomedicine employed with therapeutic agent to cross the BBB alone with biodistribution of the drugs.

Results:

We found that various types of polymeric nanoparticle systems are available and they prosper in delivering
the therapeutic amount of the drug to the targeted area. The effect of physicochemical properties on nanoformulation
includes change in their size, shape, elasticity, surface charge and hydrophobicity. Surface modification of polymers
or nanocarriers is also vital in the formulation of nanoparticles to enhance targeting efficiency to the brain.

Conclusion:

More standardized methods for the preparation of nanoparticles and to assess the relationship of surface
modification on drug delivery. While the preparation and its output like drug loading, particle size, and charge, permeation
is always conflicted, so it requires more attention for the acceptance of nanoparticles for brain delivery.
Current Status of Drug Delivery Approaches and Assay of Anti-Migraine Drugs
Authors: Esim Ozgur , Savaser Ayhan , Karadurmus Leyla , Bakirhan Nurgul K. , Ozkan Sibel A. , Ozkan Yalcin
Published: May 2020

Migraine is a chronic, painful, neurological disorder that affects approximately 15% of the
population worldwide. It is a form of neurovascular headache: a disorder in which neural events result
in the dilation of blood vessels that, in turn, results in pain and further nerve activation. The pathogenesis
of migraine is not completely understood, but it is thought that both central and peripheral
stimulations can play a role in migraine. Experimental pharmacological evidence suggests that some
drugs can have actions in migraine treatment and oral drug delivery is the first choice for these drugs.
However, the oral absorption of many drugs is delayed during migraine attacks. Therefore, there may
be an advantage to other drug delivery routes, such as parenteral and intranasal. Moreover, nanoparticles
can be used for improved drug delivery of anti-migraine agents as they can protect the encapsulated
drug from biological and/or chemical degradation, and extracellular transport by P-gp efflux
proteins. Various analytical studies have been performed to sensitive and selective assays of antimigraine
drugs from commercial and real samples. Anti-migraines, either single or combined with
other drugs, can be easily detected by several analytical methods, such as ultraviolet spectrometry,
visible spectrometry, high-performance liquid chromatography, liquid chromatography-mass spectrometry,
and high-performance thin layer chromatography. This review focuses on the status of antimigraine
drug delivery technologies and possible routes for drug delivery. Moreover, it will present
their analytical assays with different methods.
Drug Conjugates Using Different Dynamic Covalent Bonds and their Application in Cancer Therapy
Authors: Theodosis-Nobelos Panagiotis , Charalambous Despina , Triantis Charalampos , Rikkou-Kalourkoti Maria
Published: May 2020

Polymer-drug conjugates are polymers with drug molecules chemically attached to polymer
side chains through either a weak (degradable bond) or a dynamic covalent bond. These systems are
known as pro-drugs in the inactive form when passing into the blood circulation system. When the prodrug
reaches the target organ, tissue or cell, the drug is activated by cleavage of the bond between the
drug and polymer, under certain conditions existing in the target organ. The advantages of polymer-drug
conjugates compared to other controlled-release carriers and conventional pharmaceutical formulations
are the increased drug loading capacity, prolonged in vivo circulation time, enhanced intercellular uptake,
better-controlled release, improved therapeutic efficacy, and enhanced permeability and retention
effect. The aim of the present review is the investigation of polymer-drug conjugates bearing anti-cancer
drugs. The polymer, through its side chains, is linked to the anti-cancer drugs via dynamic covalent
bonds, such as hydrazone/imine bonds, disulfide bonds, and boronate esters. These dynamic covalent
bonds are cleaved in conditions existing only in cancer cells and not in healthy ones. Thus, ensuring the
selective release of drug to the targeted tissue, reducing in this way, the frequent side effects of chemotherapy,
leading to a more targeted application, despite the nature of the applied polymer, possessing the
ability to aim tumors selectively via incorporation of a relative ligand.
Carbon Nanotubes: An Emerging Drug Delivery Carrier in Cancer Therapeutics
Authors: Panigrahi Biman Kumar , Nayak Amit Kumar
Published: May 2020

Background:

The scope of nanotechnology has been extended to almost every sphere of our
daily life. As a result of this, nanocarriers like Carbon Nanotubes (CNTs) are gaining considerable attention
for their use in various therapeutic and diagnostic applications.

Objective:

The objective of the current article is to review various important features of CNTs that
make them as efficient carriers for anticancer drug delivery in cancer therapeutics.

Methods:

In this review article, different works of literature are reported on various prospective applications
of CNTs in the targeting of multiple kinds of cancerous cells of different organs via the loading
of various anticancer agents.

Results:

Actually, CNTs are the 3rd allotropic type of the carbon-fullerenes that are a part of the cylindrical
tubular architecture. CNTs possess some excellent physicochemical characteristics and unique
structural features that provide an effective platform to deliver anticancer drugs to target specific sites
for achieving a high level of therapeutic effectiveness even in cancer therapeutics. For better results,
CNTs are functionalized and modified with different classes of therapeutically bioactive molecules via
the formation of stable covalent bonding or by the use of supramolecular assemblies based on the noncovalent
interaction(s). In recent years, the applications of CNTs for the delivery of various kinds of
anticancer drugs and targeting of tumor sites have been reported by various research groups.

Conclusion:

CNTs represent an emerging nanocarrier material for the delivery and targeting of numerous
anticancer drugs in cancer therapeutics.
Nociceptin/Orphanin FQ Peptide Receptor-Related Ligands as Novel Analgesics
Authors: Kiguchi Norikazu , Ding Huiping , Kishioka Shiroh , Ko Mei-Chuan
Published: May 2020

Despite similar distribution patterns and intracellular events observed in the nociceptin/
orphanin FQ peptide (NOP) receptor and other opioid receptors, NOP receptor activation displays
unique pharmacological profiles. Several researchers have identified a variety of peptide and nonpeptide
ligands to determine the functional roles of NOP receptor activation and observed that NOP receptor-
related ligands exhibit pain modality-dependent pain processing. Importantly, NOP receptor activation
results in anti-nociception and anti-hypersensitivity at the spinal and supraspinal levels regardless
of the experimental settings in non-human primates (NHPs). Given that the NOP receptor agonists synergistically
enhance mu-opioid peptide (MOP) receptor agonist-induced anti-nociception, it has been
hypothesized that dual NOP and MOP receptor agonists may display promising functional properties as
analgesics. Accumulating evidence indicates that the mixed NOP/opioid receptor agonists demonstrate
favorable functional profiles. In NHP studies, bifunctional NOP/MOP partial agonists (e.g., AT-121,
BU08028, and BU10038) exerted potent anti-nociception via NOP and MOP receptor activation; however,
dose-limiting adverse effects associated with the MOP receptor activation, including respiratory
depression, itch sensation, physical dependence, and abuse liability, were not observed. Moreover, a
mixed NOP/opioid receptor agonist, cebranopadol, presented promising outcomes in clinical trials as a
novel analgesic. Collectively, the dual agonistic actions on NOP and MOP receptors, with appropriate
binding affinities and efficacies, may be a viable strategy to develop innovative and safe analgesics.
Comparative Study of Antimicrobial Activity and Cytotoxicity of Saponin Extracted from Six Egyptian Sea-cucumber Species, Licorice, and Ginseng
Authors: Eissa Samia H. , Salem Hoda K. , Omran Nahla E. , Kabbash Amal M. , Amer Wesam H. , Kandeil Manar A.
Published: May 2020

Background:

The study aimed to compare the antimicrobial activity and cytotoxicity of
saponin extracted from six sea-cucumber species, licorice, and ginseng to determine the most potent
one.

Methods:

Antimicrobial activity assessed by well diffusion and agar dilution methods. The inhibitory
effects of the tested extracts on cell growth of Liver (HePG-2) and breast (MCF-7) cell lines assessed
by MTT [3- (4, 5- dimethyl thiazol-2yl) - 2, 5- diphenyl tetrazolium bromide] assay.

Results:

The results revealed that licorice extract presented higher antibacterial activity against
Gram-positive bacterial strains than sea-cucumber extracts; but has comparable results for Gramnegative
(Salmonella tyhimurium, Klebsiella spp, and Acinetobacter baumanii). Holothuria atra
body wall and Bohadschia tubules have the highest antifungal effect against Candida albicans, Candida
krusei, Candida famata, Candida glabrata, and Candida tropicalis. Sea-cucumbers are more
potent against fungal strains than licorice and ginseng extract. Licorice and ginseng presented higher
cytotoxicity against HePG2 and MCF-7 cell lines than sea-cucumbers.

Conclusion:

This study promotes the use of licorice extract as a better antibacterial substance than
sea-cucumber extracts; however, the use of sea-cucumber extracts as antifungal agents than herbal
extracts. Also, we support the utilization of licorice and ginseng as a cytotoxic agent instead of seacucumbers
to stop the fishing of animals and consequently save it from extinction.
Pricing holder-extendable call options with mean-reverting stochastic volatility
Authors: Ibrahim Siti Nur Iqmal , Diaz-Hernandez Adan , O'Hara John G. , Constantinou Nick
Published: May 2020

Options with extendable features have many applications in finance and these provide the motivation for this study. The pricing of extendable options when the underlying asset follows a geometric Brownian motion with constant volatility has appeared in the literature. In this paper, we consider holder-extendable call options when the underlying asset follows a mean-reverting stochastic volatility. The option price is expressed in integral forms which have known closed-form characteristic functions. We price these options using a fast Fourier transform, a finite difference method and Monte Carlo simulation, and we determine the efficiency and accuracy of the Fourier method in pricing holder-extendable call options for Heston parameters calibrated from the subprime crisis. We show that the fast Fourier transform reduces the computational time required to produce a range of holder-extendable call option prices by at least an order of magnitude. Numerical results also demonstrate that when the Heston correlation is negative, the Black–Scholes model under-prices in-the-money and over-prices out-of-the-money holder-extendable call options compared with the Heston model, which is analogous to the behaviour for vanilla calls.

doi:10.1017/S1446181119000142
Experiences and Partnership Expectation Women and Midwife in Midwifery Care: A Review of Qualitative Study Systhematic
Authors: Vaira Rizky
Published: May 2020

The partnership of Midwives and women is the philosophy of Midwifery care in the period of decline, which occurred the violence and not mutually appreciated especially during childbirth in developing countries. The aim to explore the experiences of women and Midwives, strategy and expectation of women and Midwives in Midwifery services. This study using electronic methods Searches of PubMed bibliographic database, ScienceDirect, Proquest is done systematically from 2008 to 2018. Quality Articles are chosen based on the criteria of inclusion and extracting results from article 858 into 10 Articles, and then classify the comparison results to developing countries and developed countries. Based on the results of the review found the experience of women and Midwives for care in developing countries less well Because there is no Accompanying childbirth, there is physical or verbal violence, and hospital facilities that do not support. While the experience of women in developed countries and Midwives Midwives, either Because the present critical period in time, there is a sense of care from Midwives who Become partners for women. Partnership Midwives and women since pregnancy Contribute to vaginal birth. Midwives and women have hope that Midwifery services can be given a maximum, qualified and manifested a sense of mutual understanding and respect for each other. The condition of Midwifery care in developing countries need particular attention. The importance of the presence of a midwife, care of ongoing and Partnered with women can suppress violence in orphanages. The Government needs to provide training to Midwives on counselling skills, build interpersonal relations, and effective leadership in Midwifery services.
Art Therapy on the Cognitive Function of Elderly with Dementia
Authors: Dewi MPP Murdiyanti Prihatin Putri
Published: May 2020

The aging process continues as time goes by and there will be an impairment of the organ. Decreased body functions that often appear one of them is a decrease in cognitive function. Most of the elderly experienced dementia by showing changes in behavior. This study was to identify the effect of  art therapy on cognitive function of the elderly with dementia with the design of this study was Quasy Experimental Pre-Post Control Goup Design. There were 82 respondents divided into control groups and intervention groups. Measurement of cognitive function of the elderly with dementia using the Mini-Mental State Examination (MMSE). The result of the research showed that there was a significant improvement of the cognitive function in elderly with dementia after art therapy for 4 (four) weeks. It can be concluded thatbrain exercise and art therapy exercise can be applied to increase cognitive function towards the elderly.
Interleukin-6 role in the severity of COVID-19 and ICU stay length (Preprint)
Authors: Abdulkarimi Rahim
Published: May 2020

BACKGROUND

Evaluation of cytokine production in COVIID-19 disease, in which the cytokine storm is one of the most important pathological features in complicated cases, especially interleukin 6 as a pre-inflammatory cytokine that exacerbates the immune response, could help determine the pathophysiology of the disease.

OBJECTIVE

Examining the level of this cytokine along with other related factors can help to better understand the pathogenesis of this disease

METHODS

In this cross-sectional study, 48 patients with COVID-19 whose disease was confirmed by swap testing were evaluated. The demographic information of the individuals, the symptoms of the disease, and the ward in which they were admitted were recorded. Blood samples were taken from patients to test for interleukin-6 levels by ELC testing. Due to the lack of specific treatment protocols for patients and the use of supportive treatments based on meeting the nutritional needs for all patients, blood albumin levels and nutritional status of patients were also evaluated using Subjective Global Assessment (SGA) Form. Their calorie intake was assessed by calculating the number of calories received based on the type of nutrition and compared to the required amount calculated through the Harris-Benedict equation. 48 laboratory-confirmed 2019-nCoV infected patients were included in the study with the mean age of 46.4 ± 8.3 years. 21 patients were admitted to the ICU.

RESULTS

There was no significant difference between the ICU admitted and patients admitted inward in terms of demographic characteristics, and history of previous diseases (P> 0.05). The average IL-6 in patients was 72.3±34.4 pg/ml. ICU admitted patients had higher IL6 levels (p=0.001). The mean interleukin 6 level was 89.04±34.1 pg/ml in patients admitted for less than 7 days and it was significantly higher (119.2±28.3) in patients hospitalized for more than 7 days (p=0.001). there was no significant difference in terms of nutritional status and albumin level between ICU admitted and ward admitted patients (P>0.05).

CONCLUSIONS

our study shows that there may be possible associations of IL6 and disease severity and ICU stay length.
Outbreak & Current Situation of Coronavirus Disease 2019 (COVID-19) in Pakistan (Preprint)
Authors: Khan Safiullah , Bugti Anwer , Samad Abdul , Ahmed Jawad , Khan Asad
Published: May 2020

UNSTRUCTURED

Coronavirus Disease 2019 (COVID-19) continues to spread all around the world, affecting 212 countries that originated from Wuhan, China. In Pakistan, spread of COVID-19 infection is experienced at exponential rate. Until 3rd May, 2020, total 3,470,277 COVID-19 cases with 243,966 mortalities and 2,112,147 active cases have been reported globally. The rapid increase in figure constrained the nations to initiate various steps to cope with the COVID-19 pandemic. Pakistan has also shown its efforts by taking various steps as preventive measures for the containment of this pandemic including screening at all entry point to the country, strengthening surveillance system, provision of health facilities and fiscal plan. Furthermore, strengthening of health sector by devising new strategies and hiring of expert professionals scientists will be pivotal to cope with COVID-19 pandemic.
Promoting Psychological Wellbeing across the Life Span: Prospects and Challenges in Nigeria
Authors: Funmi Togonu-Bickersteth , Modupe Taiwo , Oluwasegun Oluwaleimu
Published: May 2020

Psychological wellbeing consists of two philosophical perspectives: hedonic and eudaimonic viewpoints. These paradigms are developed and changes overtime across life span subject to life course experiences influenced by the individual’s live experience. More importantly early years’ experience moderate individuals’ psychological wellbeing as being positive or negative with attendant consequences. Understanding psychological wellbeing across developmental life course provides useful insights for life adjustment as individual, families and groups to navigate life turbulence.
Conductas irracionales y de racionalidad limitada en las organizaciones gubernamentales
Authors: Piña Sánchez Antonio Javier , Guzmán Arias Gabriela Natarely , Ruíz De La Peña Zavaleta Alberto
Published: May 2020

El objetivo del artículo es ampliar el estudio de las políticas públicas desde una óptica organizacional, al abrir al debate a la discusión acerca de los comportamientos gubernamentales que se materializan en un sentido racional, de racionalidad limitada o irracional. Para ello se utiliza el enfoque de políticas públicas y la economía conductual, y se efectúo un análisis comparativo para establecer categorías de análisis ambos en campos disciplinarios. Entre los resultados se identificaron elementos conductuales de vinculación entre la economía conductual y las políticas públicas. En las conclusiones se destaca que. en las organizaciones gubernamentales existen comportamientos racionales, de racionalidad limitada e irracionales; cooperativos y no cooperativos que son benéficos o perjudiciales para las mismas. Estas conductas amplían y reintegran la variable organizacional en el estudio de las políticas públicas.
Gobierno abierto: buen gobierno o corrupción en México, 2013-2018
Authors: Sánchez Ramos Miguel Ángel de Guadalupe , Castillo de la Rosa Shantay
Published: May 2020

El objetivo es analizar la relación entre gobierno abierto, corrupción y disposición al buen gobierno en México, 2013 al 2018. Los intentos en México por construir un gobierno abierto son débiles y desiguales, asociados con más corrupción, lo que ha producido una disposición baja al buen gobierno. El gobierno mexicano ha desplegado acciones parciales y no como parte de una estrategia holística que condujera al mejoramiento general de las condiciones de vida. La parcialidad en los esfuerzos gubernamentales redunda en la menor acogida de efectividad por parte del ciudadano, produciendo desconfianza y mayor percepción de corrupción. Los niveles de descomposición son de tal nivel que el estado de derecho no se percibe como ligado a los elementos del gobierno.
DESISTIR NÃO É UMA OPÇÃO
Authors: Lemos Fernanda Moojen , Sensi Filho Mário Antônio , Lana Jeferson
Published: May 2020

Este caso para ensino tem como principal objetivo elucidar o aluno sobre o mercado de opções e algumas possíveis estratégias. Rafael, protagonista da história, reencontra um velho amigo de faculdade, João Paulo, o qual obteve grandes resultados investindo no mercado de opções, incomodado pela baixa rentabilidade de seus investimentos, Rafael inicia seu aprendizado e sua busca por atingir seus objetivos futuros seguindo as dicas do colega, porém encontra-se divido entre a possibilidade de grandes resultados e colocar em risco o dinheiro economizado para compra do seu apartamento. O presente caso de ensino utilizou informações reais do mercado financeiro para simular o primeiro investimento em opções de ações por Rafael, e se torna importante por retratar a dificuldade enfrentada por investidores frente a complexidade do mercado de opções, que acaba fazendo com que, apresente uma baixa liquidez para poucos ativos e acabe sendo pouco explorado no Brasil. Este material é indicado para alunos de graduação e pós-graduação, dentro da disciplina de mercado de capitais, que já tenham um prévio conhecimento do assunto.
Algorithm for determining the orientation elements of an infrared image obtained from a drone using reference points
Authors: Mokrova S.M. , Petrov R.P. , Milich V.N.
Published: May 2020

The article deals with the algorithm for determining the exterior and interior orientation elements of an infrared image obtained from an unmanned aerial vehicle using four reference points. The idea of the proposed algorithm is to determine the true position of the image by the defined three-dimensional spatial coordinates of the reference points in the image at the time of shooting. The image plane is built up on the defined points. The coordinates of the principal point of the image are calculated by making a perpendicular from the perspective center to the plane of the image. The focal length is equal to the length of this perpendicular. Euler angles characterizing the position of the camera at the time of shooting are calculated after determining the axes’ directions of the inclined image coordinate system. The proposed algorithm is effective even in the case when all the elements of the image orientation are unknown. Calculations of the image elements on model examples with different initial data show high accuracy. The possibility of obtaining the necessary accuracy for the orthotransformation procedure was confirmed on real images.
Pemanfaatan Internet untuk Meningkatkan Minat Baca Mahasiswa PLS IKIP Siliwangi
Authors: Putri Shindriani
Published: May 2020

Abstract This research is motivated by the use of the internet by university student and their lack of interest in university student coming to the library, as well as their lack of interest in reading. The lack of interest in reading university student depends on the role of parents in paying attention to unoversity student activities. Low interest in reading can affect the progress of the nation's generation. The theory used in this research is technology theory, literacy theory. The method used is qualitative with interview and questionnaire techniques. The results of this study, namely the development of technology in students' low interest in reading. University student interest in reading in reading can be seen from the participation of students when attending lectures and the lack of interest in reading university students is caused by the lack of attention, support, the rapid technological factors, library management and supervision of the family of its activities.Abstrak Penelitian ini dilatar belakangi oleh penggunaan internet oleh mahasiswa dan kurang minatnyamahasiswa untuk datang ke perpustakaan, serta kurang minatnyamahasiswa untuk membaca. Kurangnya minat membaca mahasiswa tergantung pada peran orang tua dalam memperhatikan kegiatan mahasiswa. Minat yang rendah dalam membaca dapat mempengaruhi kemajuan generasi bangsa. Teori yang digunakan dalam penelitian ini adalah teori teknologi, teori literasi. Metode yang digunakan adalah kualitatif dengan teknik wawancara dan kuesioner. Hasil penelitian ini, yaitu dengan adanya perkembangan teknologi minat baca mahasiswa rendah. Minat baca mahasiswa dalam membaca dapat dilihat dari keikutsertaan mahasiswa ketika menghadiri kuliah dan rendahnya minat membaca mahasiswa disebabkan oleh kurangnya perhatian, dukungan, faktor pesatnya teknologi, pengelolaan perpustakaan dan pengawasan dari keluarga terhadap kegiatannya.
PEMANFAATAN YOUTUBE DALAM UPAYA MENINGKATKAN KETERAMPILAN MASYARAKAT RW.06 CIBEBER MENGENAI PENGELOLAAN SAMPAH
Authors: Nurislam Jihan Shavira
Published: May 2020

Abstrak Penelitian ini dilatar belakangi oleh fakta adanya permasalahan sampah yang ada di lingkungan masyarakat  cibeber yang membuat resah. Tujuannya adalah untuk meningkatkan kreativitas masyarakat dalam pengelolaan sampah. Kemudian landasan teori yang digunakan dalam teori ini adalah teori pemanfaatan youtube, teori pengelolaan sampah dan teori pengembangan masyarakat. Metode penelitian yang digunakan adalah kualitatif dengan mendeskripsikan apa yang sudah diteliti dan melakukan observasi secara langsung. Hasil dari penelitian ini menunjukan bahwa media sosial youtube sangat bermanfaat untuk memberikan pemah  aman terhadap masyarakat dalam meningkatkan keterampilan dalam pengelolaan sampah. Kesimpulan dari penelitian ini menunjukan bahwa pemanfaatan media sosial sangat diperlukan agar masyarakat sadar dan paham bagaimana cara mengelola sampah yang asalnya tidak bernilai menjadi barang yang bernilai.AbstractThis research is motivated by the fact that there are garbage problems in the Cibib community that makes people uneasy. The aim is to increase community creativity in waste management. Then the theoretical basis used in this theory is YouTube utilization theory, waste management theory and community development theory. The research method used is qualitative by describing what has been studied and direct observation. The results of this study indicate that the use of social media youtube is very useful to provide understanding to the community in improving skills in waste management. The conclusion from this study shows that the use of social media is very necessary so that people are aware and understand how to manage waste that is of no value into valuable goods.
PROFIL PEMANFAATAN LITERASI TEKNOLOGI DAN INFORMASI (TIK) OLEH PENILIK KOTA CIMAHI
Authors: Cholifah Ifah , Ansori Ansori , Mulyono Dinno
Published: May 2020

Abstract The development of information and communication technology (ICT) at this time cannot be avoided by various parties. This development has positive and negative impacts on human life. However, these impacts can be managed by humans themselves such as by studying and utilizing these developments in daily life, there will be many positive impacts felt, one of which facilitates the search and dissemination of information, as well as accelerating and facilitating work. However, in reality, utilizing ICT in daily life in accordance with the work of each individual has not been fully implemented. Therefore, this research was carried out with the aim to find out the profile of the use of ICT by Menelik in the Cimahi city education department. The instrument used was a questionnaire that was developed in accordance with ICT literacy level indicators. The results of his research show that the use of ICT by the Penilik in the Cimahi city education office is in the medium category or can be interpreted quite wellKeywords:  penilik, literacy, ICT  Abstrak Perkembangan teknologi informasi dan komunikasi (TIK) pada saat ini tidak dapat dihindari oleh berbagai pihak. Perkembangan ini memberikan dampak yang positif dan negatif bagi kehidupan manusia. Akan tetapi dampak tersebut dapat di kelola oleh manusia itu sendiri seperti dengan mempelajari dan memanfaatkan perkembangan tersebut dalam kehidupan sehari-hari maka akan banyak dampak positif yang dirasakan salah satunya mempermudah pencarian dan penyebaran informasi, serta mempercepat dan mempermudah pekerjaan. Akan tetapi dalam kenyataannya memanfaatkan TIK dalam kehidupan sehari-hari sesaui dengan pekerjaan masing-masing individu belum sepenuhnya dilaksanakan. Oleh karana itu, dilaksanakan penelitian ini dengan tujuan untuk mengetahui profil pemanfaatan TIK oleh penilik di lingkungan dinas pendidikan kota Cimahi. Intrumen yang digunakan adalah angket yang dikembangkan sesuai dengan indikator tingkat literasi TIK. Hasil penelitiannya menunjukan bahwa pemanfaatan TIK oleh penilik di lingkungan dinas pendidikan kota Cimahi berada pada kategori sedang atau dapat diartikan cukup baik.Kata Kunci: penilik, literasi, TIK
Circulating Protein Signatures and Causal Candidates for Type 2 Diabetes
Authors: Gudmundsdottir Valborg , Zaghlool Shaza B. , Emilsson Valur , Aspelund Thor , Ilkov Marjan , Gudmundsson Elias F. , Jonsson Stefan M. , Zilhão Nuno R. , Lamb John R. , Suhre Karsten , Jennings Lori L. , Gudnason Vilmundur
Published: May 2020

The increasing prevalence of type 2 diabetes poses a major challenge to societies worldwide. Blood-based factors like serum proteins are in contact with every organ in the body to mediate global homeostasis and may thus directly regulate complex processes such as aging and the development of common chronic diseases. We applied a data-driven proteomics approach, measuring serum levels of 4,137 proteins in 5,438 elderly Icelanders, and identified 536 proteins associated with prevalent and/or incident type 2 diabetes. We validated a subset of the observed associations in an independent case-control study of type 2 diabetes. These protein associations provide novel biological insights into the molecular mechanisms that are dysregulated prior to and following the onset of type 2 diabetes and can be detected in serum. A bidirectional two-sample Mendelian randomization analysis indicated that serum changes of at least 23 proteins are downstream of the disease or its genetic liability, while 15 proteins were supported as having a causal role in type 2 diabetes.
Pengaruh Model Konseling Behavioral dengan Strategi Self-Management Terhadap Self Order
Authors: Widiantari Ni Luh Putu , Suarni Ni Ketut , Gading I Ketut
Published: May 2020

This study was aimed to know the influence of behavioral counseling model by using self-management strategy toward self-order of grade X students of SMK Negeri 2 Singaraja. The research design used was quasi experimental research in which the design used was post-test only control group design. The population of this study was grade X students of SMK Negeri 2 Singaraja. Furthermore, the sampling technique in this research waspurposive sampling. The data of self-order was collected by using questionnaire method.The collected data was in the form of interval data.Statistic non-parametic test of Mann Whitney test was used to determine whether there was an influence of behavioral counseling method by using self-management toward self-order of the students. The result of the analysis by using Mann Whitney test showed that Z = -3,148 and sig obtained was 0,002. It indicated that significance value obtain was smaller than a in whichit was 0,05 (0,002 < 0,05). Therefore, it could be concluded that “there was an influence of behavioral counseling model by using self-management strategy toward self-order of grade X students of SMK Negeri 2 Singaraja”. Keywords: order, behavioral counseling model, self-management strategy.
Model Konseling Psikoanalisa dengan Teknik Asosiasi Bebas untuk Meminimalisir Self Heteroseksual
Authors: Yunita Nivea Vila , Suranata Kadek , Suarni Ni Ketut
Published: May 2020

This study aims to determine the effectiveness of the implementation of psychoanalysis counseling with free association techniques to minimize self heteroseksual class VIII B in SMP Negeri 3 Singaraja. The research design used is Nonequivalent Control Group Design. Sampling of this research using intaq group with the number of members as much as 74 students, each divided into 37 students experimental group with 37 students control group. Analysis methods used were (1) Rasch analysis to transform logit scale data, (2) t-brunning to calculate the effectiveness of counseling model of psychoanalysis with free association technique, and (3) t-test to know the effect difference between psychoanalytic counseling model with guidance of classical counseling to heterosexuals in students. The results showed that (a) psychoanalysis counseling with effective free association technique to minimize heterosexual self with thitung > ttable (212,7 > 1,688), (b) There is difference of effectiveness of psychoanalytic counseling model heterosexual effect size 508,35 with guidance of classical counseling to efeect size 0,19 Keywords: Rasch, Analysis, Associations, technique, Psychoanalysis, Counseling, Self Heterosexual
Konseling Bevahioral dengan Teknik Role Playing Melalui Lesson Study untuk Meningkatkan Self Afiliasi
Authors: Jayanti Ni Kadek Dwi , Dantes Nyoman , Dharsana I Ketut
Published: May 2020

This study was aimed to determine the effectiveness of the implementation of behavioral counseling theory by using role playing technique to improve student self-affiliation, and to know the difference of self-affiliation between the students who were given behavioral counseling by using role playing technique and the students who were not given in which the students were grade VIII students of SMP Lab Undiksha Singaraja. The population of this research was all students of grade VIII SMP Lab Undiksha Singaraja. The sample of this research was determined by random sampling technique. The methods of data collection in this study used the observation methods, interviews, diaries and self-affiliated scheme questionnaires of Likert scale. The data analysis method for the hypothesis test used the t-test. The results of this study indicated that there was effectiveness of behavioral counseling theory by using role playing technique to improve self-affiliation of grade VIII students of Undiksha SMP Lab Undiksha Singaraja and there were differences of self-affiliation between the students who were given behavioral counseling by using role playing technique and the students who were not given. Keywords: Behavioral Counseling,  Role Playing Technique, Self-affiliation
Konseling Behavioral dengan Strategi Self Management untuk Meningkatkan Kemandirian
Authors: Antara Made Pradnyana , Dharsana I Ketut , Suarni Ni Ketut
Published: May 2020

This study was aimed to know whether the behavioral counseling by using self-management strategy was effective to improve self-autonomy students through lesson study toward grade XI IPA students of SMA Negeri 1 Sukasada and to know the difference between students who were given behavioral counseling by using self-management strategy and the students who were not given the treatment. This type of the research was quasi experimental design with nonequivalent pre-test post-test control group design. The technique of the sampling used was random sampling and random class as the intact group. This study used two classes, XI IPA 1 with 18 students as the experimental class and XI IPA 2 with 18 students as the control class. The process of data collection in this study used the observation methods, interviews, diaries and self-esteem autonomy patterns of linkert scale and analyzed descriptively for statistical analysis used the t-test formula. To test the hypothesis, it was used the t test, with the results in the first hypothesis which found that tcount> ttable (10.86> 1.739) which meant that there was effectiveness of the implementation of behavioral counseling theory by using self-management strategy to improve self-autonomy through lesson study toward the students of XI IPA 1 and the result of the second hypothesis found that tcount> ttable (8.70> 2.03) which meant that there was a difference of self-autonomy between the students who were given behavioral counseling by using self-management strategy and the students who were not given behavioral counseling by using self-management strategy toward grade XI IPA students of SMA Negeri 1 Sukasada. Keywords: behavioral conseling, Self-Management Strategy , Self-Autonomy
Konseling Behavioral dengan Tehnik Modeling dan Tehnik Latihan Keterampilan Sosial untuk Meningkatkan Self Change
Authors: Adnyani Ni Nyoman Sri Agustini , Dharsana I Ketut , Suranata Kadek
Published: May 2020

The purpose of this study was to improve the Self Change character of SMK Negeri 3 Denpasar Students. The low character of self-change of students is very interesting to be discussed and disclosed in a research study. This type of research is Experimental Research, with the design of pretest-group control group design. This research population is all class X of SMK Negeri 3 Denpasar. A sample of 102 students was taken randomly from the class and from the results of the distribution of self-change questionnaires, which were calculated using the T formula. The results of modeling techniques and social skills techniques showed that social skills techniques were effective in increasing self-change characteristics, while Modeling techniques were not effective change. This result is evidenced by the value of Fcount obtained at 29.944 and Ftable of 5.29. Compared to the value of Fcount with Ftable it is found that Fcount> Ftable with a significance level (p)> 0.01, it can be concluded that there are differences in the effectiveness of behavioral counseling between modeling techniques with Skill techniques Social to self change.Keywords: Self Change, Behavioral Counseling, Modeling Techniques, Social Skills Training Techniques.
Konseling Behavioral dengan Teknik Modeling untuk Meningkatkan Self Achievement
Authors: Cahyuni Nurul Ardhia , Tirka I Wayan , Suranata Kadek
Published: May 2020

This study aims to determine the effectiveness of behavioral counseling with modeling techniques to improve self achievement in class VII I Junior High School 3 Singaraja. This type of research is quasi-experimental with pre-test and post-test control group design. These samples included 68 students (male 34 and female 34, average age 12.5 years). Through random sampling, 34 students were placed in the experimental group who received treatment with behavioral counseling and modeling techniques, 34 students as a control group not received treatment. The results of the data analysis are the value of thit 2.978 > ttab 2.021 so that Ho is rejected and Ha is accepted. So there are significant differences. It can be concluded that behavioral counseling with modeling technique is effective for increasing self achievemet in class VII I Junior High School 3 Singaraja.Keywords: Behavioral Counseling, modeling, self achievement
Efektivitas Konseling Behavioral dengan Teknik Modeling untuk Meningkatkan Self Autonomy melalui Lesson Study
Authors: Laila Irda , Dharsana I Ketut , Suarni Ni Ketut
Published: May 2020

This research aims to determine the effectiveness of behavioral counselling techniques Modeling to improve Self Autonomy through lesson study in students of class X UPW B SMK N 1 Singaraja. This type of research is research draft of Pseudo experimental population of this study is grade X students smkn 1 Singaraja. Sampling technique uses Random sampling so that the grade X student is acquired by an experimental class of 36 grade X APH A students as a control group amounting to 36 students. The method of analysis used is the ttest test and Efect Size that uses the program JASP 0.7.5.5. Data collection instruments using observations, interviews, diary and questionnaire results based on the results of this study can be recommended that this counselling model is effective to do in the process. Research shows that there is effectiveness of behavioral counseling theory with modeling technique in setting lesson study to improve Self Autonomy class X UPW students.Keywords: Self Autonomy, Behavioral Counseling, Modeling Techniques, LessonStudy