bluuebunny/crossref_metadata_2025 huggingface dataset:
Estimation of Least Squares Means and Non-genetic Factors for Reproduction Traits in Frieswal Cattle under Field Progeny Testing
Authors: Sarma Olympica , Barwal R.S. , Rather Mubashir Ali , Ghosh A.K. , Shahi B.N.
Published: January 2025

Background: The reproduction traits are quantitative traits governed by polygenic inheritance and influenced by non-genetic managemental factors to a greater extent as their heritability values are low. This investigation was undertaken to study the effect of period and season of calving in Frieswal cattle under field progeny testing programme. Methods: The data on Frieswal cattle,pertaining to a period of nine years (2013-2021), from field progeny testing were used for this study and the six reproductive traits studied were age at sexual maturity (ASM), age at first calving (AFC),gestation period (GP), first calving interval (FCI), first service period (FSP), first dry period (FDP) and number of services per conception (NSPC). The data analysis was performed using the mixed model least squares and maximum likelihood PC-2. The impact of non-genetic factors on the traits and statistical significance of various fixed effects in the least squares model was determined using the ‘F’ test in SPSS software. Significant effects were further analyzed by using Duncan’s multiple range test (DMRT). Result: The overall least squaresmeans of 810.59±6.57, 1088.65±6.57, 278.06±0.16, 373.14±0.41, 95.08±0.45, 1.47±0.02 and 62.59±0.14 for ASM, AFC, GP, FCI, FSP, FDP andNSPC, respectively, were observed in the present study. The highest and lowest coefficient of variation for NSPC and GP, respectively, showing the extent of variability in population. The effect of period was significant (P less than 0.01) on ASM, AFC, GP, FCI and FSP whereas effect of season was significant (P less than 0.01) on GP only. It is concluded that the prevailing location specific climatic conditions of Tarai region of Uttarakhand, with respect to feed and fodder availability influence reproduction performance and also this cattle is well adapted to the seasonal environmental fluctuation of area.
UMA ANÁLISE BASEADA EM FATOS E EVIDÊNCIAS: intempéries nas práticas de cidadania por jovens em situação de vulnerabilidade socioeconômica
Authors: Freire Valéria Pinto
Published: January 2025

Este artigo traz à tona reflexões iniciais oriundas de uma pesquisa de doutorado que explora de que maneira as juventudes em situações de vulnerabilidade socioeconômica se relacionam, respondem e se beneficiam das oportunidades de acesso às Tecnologias Digitais de Informação e Comunicação (TDIC) e à conectividade na sociedade digital globalizada, assim como das práticas de cidadania que emergem dessa realidade. O estudo analisa como essas interações influenciam práticas de cidadania e o acesso à informação de qualidade, considerando as desigualdades sociodigitais no Brasil. Com enfoque descritivo e explicativo, fundamenta-se em uma revisão bibliográfica e documental, o estudo examina marcadores sociais como raça, gênero, classe e territorialidade, explorando como essas dimensões se entrelaçam e moldam experiências distintas de acesso, uso e impacto das Tecnologias Digitais de Informação e Comunicação (TDIC) na vida cotidiana das juventudes em situação de vulnerabilidade. Além disso, revela como esses fatores potencializam a exclusão e limitam direitos e oportunidades. Os resultados corroboram que as estruturas sociais, econômicas e políticas não apenas sustentam, mas também intensificam as dinâmicas de exclusão e vulnerabilidades coletivas, perpetuando desigualdades estruturais e limitando o acesso equânime a direitos e oportunidades.
SEEING AI COMO FERRAMENTA DE INCLUSÃO NA PÓS-GRADUAÇÃO: explorando benefícios e desafios na acessibilidade para alunos com deficiência visual
Authors: Brito Silvânia Rabelo , Chahini Thelma Helena Costa , Bottentuit Junior João Batista
Published: January 2025

As Tecnologias Digitais de Informação e Comunicação (TIDC) têm promovido novas formas de interação e acesso ao conhecimento, criando várias oportunidades pedagógicas e facilitando a autonomia dos indivíduos. A tecnologia assistiva (TA), uma área interdisciplinar focada na identificação de recursos e serviços que melhoram a participação de pessoas com deficiência ou mobilidade reduzida, deve ser integrada à educação para maximizar seus benefícios. Este artigo de pesquisa visa demonstrar como o uso      das tecnologias assistivas, especificamente o aplicativo Seeing AI da Microsoft, pode contribuir para auxiliar      o acesso, permanência e atendimento educacional especializado para       alunos com deficiência visual na pós-graduação. Utilizando uma abordagem descritiva, o estudo apresenta e analisa as funcionalidades do Seeing AI, discutindo suas aplicações no contexto acadêmico. Os principais resultados mostram que tal ferramenta pode facilitar a leitura de textos e a navegação em ambientes, oferecendo suporte prático aos alunos. No entanto, limitações relacionadas à precisão em ambientes acadêmicos e à necessidade de uma conexão de internet estável também são destacadas. As informações fornecidas podem servir como base para outras instituições que buscam implementar tecnologias assistivas, promovendo uma inclusão mais efetiva para estudantes com deficiência visual no contexto desafiador do ambiente acadêmico da pós-graduação.
Navigating Chronic Disease Management with Digital Healthcare Solutions amidst the COVID-19 Pandemic: A Systematic Literature Review
Authors: Vratimos Achillefs , Champilomatis Ilias , Farantos Georgios
Published: January 2025

The purpose of this paper is to critically evaluate data collected from various studies on Chronic Disease Management during the COVID-19 pandemic and the emergence of Digital Healthcare as a means of providing innovative approaches for the management of chronic diseases.A systematic literature review was conducted based on studies found in the Pubmed database, wihle the search included studies with no publication date time limit, given that COVID–19 emerged in 2019. A Prisma diagram was created to record the way and the criteria by which we included and excluded studies for our research. Out of the 567 records identified through various sources 85 were used for a qualitative synthesis.During the first wave of the pandemic, a significant reduction or complete cancellation of scheduled health appointments was observed. At the beginning of the COVID-19 pandemic, shortages of medication used to manage chronic conditions were also recorded due to global supply chain disruptions. Since the beginning, governments acted rapidly to promote the use of teleconsultations by introducing enabling legislation and revising laws ensuring continuity of care for people with chronic diseases, thus transitioning rapidly to remote care and monitoring.The use of telemedicine and the involvement of community pharmacists for the management of chronic patients are key factors for sustained adherence. Long-term policies are vital to prevent pandemic-driven health disparities, while lessons should be derived for future preparedness, managing subsequent waves, and ensuring testing in primary care.
“Thomas theorem” and self-fulfilling prophecy: methodological analysis of concepts
Authors: Babich Nikolay
Published: January 2025

The article proposes an analysis of using «Thomas theorem» in sociological discourse against the background of the widespread belief that this «theorem» is a synonym for «self-fulfilling prophecy». The author proves that these principles describe two partially intersecting sets of situations. The main conclusion is that only some self-fulfilling prophecies are explained by «Thomas theorem» and only some cases of applicability of the theorem relate to self-fulfilling prophecies. Apparently, W.I. Thomas and R.Merton understood this terminological nuance, but then the understanding was lost. This loss obscured the meaning of Thomas's theorem. The author also analyzes the methodological value of correctly understood Thomas theorem, which consists in the possibility to incorporate human subjectivity into causally interpreted reality. This allows classifying social ontologies in Thomasian and non-Thomasian.
Leveraging social media big data to analyze internal migration
Authors: Maksimova Anastasia , Grebenyuk Alexander , Aleshkovski Ivan
Published: January 2025

The article is devoted to the development of a methodology for the study of population migration based on the analysis of big data in social networks through thesearch for patterns showing the internal migration process in the messages of social media users. The research in question allowed us to evaluate the degree of validity and relevance of digital traces of individuals as a source of empirical data on internal migration.
A software solution in the form of the Brand Analytics platform was used to generate the initial empirical data base onsisting of relocation messages published by social media users. The approbation of the methodology showed the fragmentation of research, analytical and predictive possibilities of using social networks as a source of data on intra-Russian population migration. Narrative analysis based on the formed sample of messages of users who have experience of resettlement within the country was proposed for further development of similar types of research.
Myagkov A. Yu. Indirect methods in sensitive research (in Russian). Moscow: INFRA-M, 2024. 245 p. ISBN 978-5-16-019344-1. DOI: 10.12737/2110854.
Authors: Batykov Ivan
Published: January 2025

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Recupero immunologico e soppressione virologica nei “late presenters”: uno studio retrospettivo monocentrico sulle nuove …
Authors: Svizzeretto Elisabetta , al. et
Published: January 2025

Negli ultimi anni sono stati ottenuti notevoli miglioramenti nel trattamento e nella prognosi dei pazienti con diagnosi precoce di HIV. Tuttavia, la presentazione tardiva rimane un grave problema sanitario ed è associata ad esiti peggiori e a un recupero immunologico e virologico più lento. L'obiettivo dello studio è stato quello di confrontare il recupero immunologico e la soppressione della viremia nel gruppo dei “late presenters” rispetto a quello dei “non-late presenters”.
Abbiamo condotto uno studio di coorte retrospettivo monocentrico in cui abbiamo analizzato le caratteristiche di 113 persone con HIV (PWH) che hanno ricevuto una nuova diagnosi di HIV e hanno iniziato la terapia antiretrovirale (ARV) presso la Clinica di Malattie Infettive di Perugia tra il 2018 e il 2023.
Le PWH sono state suddivise, in base alla conta dei CD4 alla diagnosi, in gruppo “late presenters” (≤350 CD4/microL alla diagnosi) e gruppo “non-late presenters” (PWH >350 CD4/microL alla diagnosi).
Confrontando questi due gruppi, abbiamo utilizzato il test x² per valutare l'associazione tra variabili.
In base allo stato immunovirologico al momento della diagnosi: 72/113 PWH (63.7%) erano late presenter, mentre 41/113 (36.3%) erano non-late presenters.
Confrontando i due gruppi per la variabile età, la differenza tra i due gruppi è risultata significativa (p<0.001): l'età mediana nei late presenters era più alta (44.5 anni) rispetto al gruppo dei non late presenter (32 anni).
Abbiamo confrontato il tempo di soppressione della viremia HIV (in mesi) e il recupero dei CD4 a 6 mesi nei due gruppi: è stata riscontrata una soppressione virologica significativamente più lenta (>6 mesi) nel gruppo dei late presenters (p=0.02); inoltre, nei late presenters il recupero dei CD4 è stato inferiore rispetto al gruppo dei non late presenter (p=0.01).
In conclusione, la presentazione tardiva rimane una sfida per la sanità pubblica. È necessario compiere ulteriori sforzi per garantire una diagnosi precoce dell'infezione da HIV.
La diagnosi precoce consente una più rapida riduzione della carica virale a livelli non rilevabili e un migliore recupero immunitario.
Pilot Evaluation of Collagen and Magnesium Supplementation Combined with Pelvic Floor Muscle Training Exercises in Women with Urinary Incontinence: Results of a Double Blind, Randomized, Clinical Trial
Authors: Nobile Vincenzo , Villa Roberta , Micieli Mariella , Amone Fabio , D’Ambrosio Erminia , Pulitano Giuseppe , Schinzari Camilla , Campi Eleonora Di , Carati Davide
Published: January 2025

Background/Objectives: Urinary incontinence (UI) is a common condition affecting women worldwide, with pelvic floor muscle training exercises (PFMT) recognized as the first-line treatment for UI. Supplementation with bioactive compounds, such as collagen and magnesium, may enhance the effectiveness of PFMT. This study aimed to evaluate the efficacy of combining a food supplement containing collagen and magnesium with PFMT in women experiencing stress (SUI), urge (UUI), or mixed (MUI) urinary incontinence. Methods: A pilot clinical trial was carried out on 44 women with stress, urge or mixed urinary incontinence. The improvement in urinary incontinence was assessed, before and after 6 weeks (W6) of product use, by the Questionnaire for Urinary Incontinence Diagnosis (QUID) and the clinical assessment of the gynecologist. Quality of life (QoL) was assessed as a secondary endpoint. Results: At Week 6, the baseline median QUID score in the active group was significantly reduced by 64% (p < 0.001), with 76% finishing the study with a negative diagnosis for UI. In contrast, the placebo group showed a reduction in QUID score by only 10% (p < 0.001), with just 25% of participants achieving a negative diagnosis for UI. QoL statistically significantly (p < 0.001) improved by 76% in the active group, while no changes were observed in the placebo group. Conclusions: Supplementation with the test product significantly improved urinary symptoms and quality of life, demonstrating a greater effect than pelvic floor muscle training (PFMT) exercises alone. The test product demonstrated efficacy across all three subtypes of UI.
Baryonic Matter, Ising Anyons and Strong Quantum Gravity
Authors: Planat Michel
Published: January 2025

We find that the whole set of known baryons of spin parity $J^P=\frac{1}{2}^+$ (the ground state) and $J^P=\frac{3}{2}^+$ (the first excited state) is organized in multiplets which may efficiently be encoded by the multiplets of conjugacy classes in the small finite group $G=(192,187)$. A subset of the theory is the small group $(48,29) \cong GL(2,3)$ whose conjugacy classes are in correspondence with the baryons families of Gell-Mann's octet and decuplet. $G$ has many of its irreducible characters that are minimal and informationally complete quantum measurements that we assign to the baryon families. Since $G$ is isomorphic to the group of braiding matrices of $SU(2)_2$ Ising anyons, we explore the view that baryonic matter has a topological origin.
We are interested in the holographic gravity dual $AdS_3/QFT_2$ of the Ising model. This dual corresponds to a strongly coupled pure Einstein gravity with central charge $c=1/2$ and AdS radius
of the order of the Planck scale. Some physical issues related to our approach are discussed.
Intrathecal Anti-Akkermansia muciniphila IgG Responses in Multiple Sclerosis Patients linked to CSF Immune cells and Disease Activity
Authors: Cruciani Caroline , Mathé Camille , Puthenparampil Marco , Tomas-Ojer Paula , Docampo Maria José , Opfer Roland , Jelcic Ilijas , Nicot Arnaud B. , Laplaud David-Axel , Martin Roland , Sospedra Mireia , Berthelot Laureline
Published: January 2025

(1) Background: Gut microbial dysbiosis, leaky gut and increased transepithelial translocation of commensal bacteria have been documented in multiple sclerosis (MS). Intrathecal IgGs specific for Akkermansia muciniphila, a gut bacterium, are increased in MS patients and associated with clinical disability. Our objective here was to explore the putative involvement of intrathecal anti-A. muciniphila IgG in MS pathogenesis by characterizing patients with different anti-A. muciniphila IgG indices. (2) Methods: Serum and intrathecal IgG specific for A. muciniphila and other gut bacteria as well as routine cerebrospinal fluid (CSF) parameters were measured in 61 MS patients. Examination of these patients included immunophenotyping of CSF-infiltrating and paired circulating lymphocytes, intrathecal markers of neurodegeneration and inflammation and a detailed characterization of demographic-, clinical-, and magnetic resonance imaging (MRI) features. (3) Results: MS patients with high anti-A. muciniphila IgG index also showed higher intrathecal IgG indices against other gut bacteria. Plasma blasts, B cells and Th2 cells that might be involved in antibody production were increased in the CSF of these patients as well as blood pro-inflammatory Th17 cells. Anti-A. muciniphila IgG indices were negatively associated with blood brain barrier (BBB) permeability and circulating monocytes and positively with brain lesion load. (4) Conclusions: The differences between patients with low and high anti-A. muciniphila IgG indexes regarding BBB permeability, CSF cell infiltrates, pro-inflammatory peripheral immune cells as well as imaging features, support a role of anti-A. muciniphila immune response in MS pathogenesis.
Enhancing Vegetation Monitoring: A Proposal for a Sentinel-2 Based Vegetation Health Index
Authors: Kumar Sandeep , Ghosh Swarnendu Sekhar , Mandal Dipankar , Bhattacharya Avik , Porwal Alok , Karthikeyan Lanka
Published: January 2025

Vegetation serves as a vital carbon sink, crucial for regulating CO2 and O2 levels in the atmosphere. However, the declining health of vegetation can contribute to a rise in greenhouse gas emissions. Utilizing remote sensing satellite imagery, we can effectively monitor global changes in vegetation health in near-real time. While various indices have been proposed for monitoring specific biochemical properties of vegetation, they often fail to detect health deterioration caused by multiple stressors like excessive heat, salinity, and water scarcity. All of the stress caused by these stressors may not be adequately identified by indices primarily sensitive to single-leaf parameters. Thus, this study introduces a novel vegetation health indicator that identifies vegetation stress-induced changes in chlorophyll, water, and protein content. This index was validated through lab-based spectroscopy experiments and global sensitivity analysis using physical models. Results from spectroscopy experiments highlight the limitations of the Normalized Difference Vegetation Index (NDVI) and the Normalized Difference Moisture Index (NDMI) in detecting specific stressors. However, the proposed index demonstrates proficiency in detecting a broader spectrum of stresses. Global sensitivity analysis indicates promising results, showing the sensitivity to chlorophyll and water content variations in the proposed index. Further analysis, focusing on the phenology of corn crops using Sentinel-2 data, demonstrates the usefulness of our new index (SVHI) in distinguishing characteristic vegetation changes while effectively differentiating non-vegetated areas like water bodies.
Evaluating the Effectiveness of the SAHER System in Enhancing Road Safety: Insights from Experts on Traffic Accidents in Dammam Metropolitan Area, Saudi Arabia
Authors: Alobaidallah Abdullatif , Alqahtany Ali Muflah , Maniruzzaman Khandoker M.
Published: January 2025

Road traffic accidents are a major global challenge, causing significant public health and economic burdens. In Saudi Arabia, the rapid increase in motorization and urbanization has led to one of the world's highest traffic fatality rates. This study examines the effectiveness of the SAHER traffic enforcement system in the Dammam Metropolitan Area (DMA) using insights from 23 road safety experts through structured questionnaires and interviews. The analysis highlights that SAHER has improved compliance with traffic laws and enhanced road safety perceptions but remains limited in its scope and coverage. Key findings identify driver distractions, speeding, and sudden lane changes as the leading causes of accidents, with younger drivers disproportionately involved. Experts emphasize the need for enhancements to SAHER, including increasing the number and strategic rotation of cameras, addressing additional violations such as aggressive driving, and improving coverage near schools and high-pedestrian areas. Recommendations include integrating SAHER into future urban planning, combining automated enforcement with public education campaigns, and improving traffic infrastructure, such as signage and signal operations. This study provides valuable insights into the role of automated enforcement in improving road safety and offers actionable strategies for policymakers to address traffic-related challenges and promote sustainable urban mobility in Saudi Arabia.
Advancing Image Compression Through Clustering Techniques: A Comprehensive Analysis
Authors: Omari Mohammed , Kaddi Mohammed , Salameh Khouloud , Alnoman Ali
Published: January 2025

Image compression is a critical area of research aimed at optimizing data storage and transmission while maintaining image quality. This paper explores the application of clustering techniques as a means to achieve efficient and high-quality image compression. We systematically analyze nine clustering methods: K-Means, BIRCH, Divisive Clustering, DBSCAN, OPTICS, Mean Shift, GMM, BGMM, and CLIQUE. Each technique is evaluated across a variety of parameters, including block size, number of clusters, and other method-specific attributes, to assess their impact on compression ratio and structural similarity index. The experimental results reveal significant differences in performance among the techniques. K-Means, Divisive Clustering, and CLIQUE emerge as reliable methods, balancing high compression ratios and excellent image quality. In contrast, techniques like Mean Shift, DBSCAN, and OPTICS demonstrate limitations, particularly in compression efficiency. Experimental validation using benchmark images from the CID22 dataset confirms the robustness and applicability of the proposed methods in diverse scenarios.
Explainable Deep Learning for Cardiac MRI: Multi-Stage Segmentation, Cascade Classification, and Visual Interpretation
Authors: Slobodzian Vitalii , Barmak Oleksandr , Radiuk Pavlo , Klymenko Liliana , Krak Iurii
Published: January 2025

Cardiac MRI images are vital in diagnosing a range of heart diseases, yet standard so-lutions frequently struggle with inadequate region delineation, confusion among simi-lar pathologies, and opaque decision-making processes. In this work, we aim to resolve these problems by introducing dedicated methods for careful region extraction, spe-cialized classification, and metric-based interpretation. Our approach notably im-proves segmentation, achieving Dice coefficients of 0.974 for the left ventricle and 0.947 for the right ventricle—outperforming prior baselines. Classification results reach a 97% overall accuracy, substantially higher than reference architectures that only attained 72–84%. Furthermore, clinical relevance is enhanced through a struc-tured output that pinpoints key anatomical and functional indicators. These findings suggest a reliable pipeline that refines MRI analysis and facilitates healthcare profes-sionals making more informed decisions in real-world medical settings.
Nanosilica Revolution: Unveiling the Impact on Enhancing Performance in Oil and Gas Well Cement
Authors: Montassir Mohamed , El-Mahallawi Iman , Salem Adel M. , Abdelhafiz Mostafa
Published: January 2025

In recent times, numerous oil and gas wells have experienced diverse failures ranging from downhole plug malfunctions to compromised wellbore integrity, resulting in damage to aquifers, loss of assets, and posing significant economic and environmental hazards. The inclusion of nanosilica into oil and gas well cement emerges as a promising solution, demonstrating a positive influence on enhancing mechanical properties, such as compressive strength and durability. This study investigates the impact of nanosilica on the mechanical properties of Class G Portland cement slurry, aiming to enhance its application in the oil and gas industry. The influence of nanosilica on the cement compressive strength behavior of oilwell cementing systems directly set and cured under the condition of 110°C and 2,000 psi is studied. Test results indicate that the cement slurries containing 3% nanosilica experienced compressive strength enhancement by 40% compared with the base sample after 24 hours. The compressive strength test results are corroborated by further evidence from a permeability test as well as microstructure analysis of the set cement. The thermal stability of the set cement samples using thermogravimetry analysis (TGA) concludes that the sample containing 3% nanosilica has the lowest mass loss. Future research should focus on long-term durability studies and comprehensive mechanical property assessments to further validate the benefits of these nanomaterials in real-world conditions.
Determinants of foreign direct investment in the Middle East and North Africa region: evidence from balanced panel data analysis
Authors: Nazzal Ahmed , Rebull María-Victoria Sánchez , Niñerola Angels Monserrat
Published: January 2025

Purpose: this study investigates factors influencing foreign direct investment (FDI) inflows to the Middle East and North Africa (MENA) region.
Approach/design: using a balanced Panel data from 24 MENA economies covering 1980-2022 we employ econometric techniques (unit root, cointegration, FMOLS, DOLS, AMG, CCEMG) to evaluate the impacts of market and resource-seeking motives, institutional, government policies (macroeconomic level), and political risk on FDI inflows into MENA region.
Findings: The long-term results suggest that market size, low corruption, government effectiveness and exchange rate contribute to FDI inflows while natural resources availability, role of law and voice and accountability deters FDI inflows to MENA. Contrary, political stability and regulatory quality factors has no significant effects on FDI inflows.
Originality/Value: the study has potential implications for boosting FDI inflows into MENA region MENA such as: Policymakers of MENA economies should adopt stable monetary policies, implement policies and regulations to Promote private sector development, improve institutional quality and maintain macroeconomic stability. Diversification of economies and reduction of reliance on natural resources are essential for long-term FDI attraction. Additionally, green innovation should be encouraged by spending more on R&D, green technology and improving policies regarding the rule of law to create a good investment environment.
Future Research: Further research is needed to explore the specific mechanisms through which these factors influence FDI inflows and to assess the potential impact of other variables, such as technological advancements and regional integration.
Extended distribution of Lycianthes biflora (Lour.) Bitter (Solanaceae) in Eastern Ghats, India
Authors: Sahu Sudam C. , Priyadarshini Sifan , Tudu Sabita , Jena Jeevan K. , Gogineni Prakash C. , Dash Sudhansu Sekhar
Published: January 2025

Lycianthes biflora (Lour.) Bitter, hitherto known only from northeastern India, is now reported for the first time from the Eastern Ghats based on a collection from the Similipal Biosphere Reserve of Odisha. The present report confirms the range extension of this species further to Eastern Ghats from northeastern region of the country. A detailed taxonomic description, ecology, phenology, distribution, field and dissected floral parts and T.S. of immature fruit photographs were provided for easy identification.
In-vitro Corrosion-Induced Strength-Ductility Degradation in WE43 and ZX10 Magnesium Alloy Fine Wires for Biomedical Applications
Authors: Ulugun Beril , Raguraman Sreenivas , Osei-Owusu Nana Barimah , Raj Sneha , Ramirez Clarence , Griebel Adam , Weihs Timothy P.
Published: January 2025

With an increasing demand for biodegradable structural materials, magnesium (Mg) alloys stand out as promising candidates. Here, we investigate the corrosion-induced mechanical degradation of fine wires made from WE43 and ZX10 Mg alloys, evaluating their suitability for biomedical applications such as scaffolds, stents, and sutures. Both alloys exhibit distinct microstructural features that influence their corrosion and mechanical behavior. WE43 wires, characterized by neodymium-rich precipitates and elongated grains, showed significant axial pitting corrosion and a rapid decline in mechanical properties attributed to micro-galvanic corrosion and potential hydrogen embrittlement. In contrast, ZX10 wires, featuring coarser and heterogeneously distributed Mg2Ca precipitates, demonstrated extensive localized pitting but retained higher ductility and toughness over extended exposure. Micro-CT analyses reveal that precipitate size, distribution, and volume fraction critically influence corrosion morphology and mechanical degradation. The findings emphasize the importance of tailoring alloy microstructures to enhance corrosion resistance and mechanical performance. While WE43's higher corrosion rates and more rapid property degradation limit its potential in applications with fine dimensions, ZX10's lower corrosion rate and higher mechanical resilience make it a more viable candidate. Future research should prioritize developing chemically homogeneous precipitates in ZX10 that are small and uniformly distributed.
Effectiveness of kinesiotherapy for tension-type headache and chronic non-specific back pain: A prospective randomized study
Authors: Golovacheva A. A. , Golovacheva V. A. , Fateeva T. G.
Published: January 2025

Introduction. Kinesiotherapy is effective in the complex treatment of patients with tension-type headache (TTH) and patients with chronic nonspecific back pain (CNBP). However, few randomized studies have been conducted on the effectiveness of kinesiotherapy in patients with TTH and CNBP.

Aim. To evaluate the effectiveness of complex treatment, including kinesiotherapy, in patients with TTH and CNBP.

Materials and methods. The study included 100 patients (23 men, 77 women, mean age 38.8 ± 9.3 years). Patients were randomized into two groups. Group 1 received complex treatment (specialized kinesiotherapy, standard drug and non-drug therapy), group 2 – standard therapy. All patients were assessed for clinical and psychological parameters at baseline and after 3 and 6 months of treatment.

Results. After 3 months of treatment, the clinical effect (CE) in the treatment of TTH (decrease in headache (H) frequency by 50% or more) and CNBP (decrease in back pain (BP) intensity according to the numeric rating scale, the Oswestry questionnaire indicator by 30% or more) in group 1 was achieved by 88% of patients, which is statistically significantly (p < 0.05) greater than in group 2 (44% of patients). More than a third (36%) of patients in group 1 did not have H and BP after 3 months, while there were no such patients in group 2. After 6 months of observation, all achieved CEs were maintained in group 1, 38% of patients achieved complete remission of H and BP; in group 2, CE was maintained only in 33% of patients, and no patient showed complete regression of HB and BP.

Conclusion. Complex treatment, including kinesiotherapy, in patients with TTH in combination with CNBP leads to a rapid (after 3 months) positive effect, which lasts for a long time (6 months).
A percepção dos Stakeholders sobre as ações de responsabilidade social empresarial: análise de uma empresa de fruticultura em Mossoró/RN
Authors:   , Brito Filho Arrilton Carlos de
Published: January 2025

Este estudo tem por objetivo comparar as diferenças de percepção entre os stakeholders em relação às ações de Responsabilidade Social Empresarial em uma empresa de fruticultura em Mossoró/RN. O trabalho traz uma discussão sobre os conceitos muitas vezes divergentes acerca da responsabilidade social, os modelos teóricos propostos por Schwartz e Carroll (2003) e Melo Neto e Froes (2001), assim como a importância a as contradições da atividade fruticultora. Trata-se de um estudo de abordagem qualitativa, quanto aos fins, refere-se a uma pesquisa descritiva, no que concerne aos meios trata-se de uma pesquisa de campo, que se desenvolverá em duas fases: na primeira etapa foi realizado o levantamento do perfil produtivo e social das empresas filiadas ao COEX, localizadas no Agropólo Fruticultor Mossoró/Assú, para identificar as empresas a serem investigadas; no segundo momento foi realizado entrevista semiestruturada com os gestores e stakeholders da Agro Melão Mossoró (pseudônimo). Os resultados indicam que as práticas de RSE desenvolvidas pela Agro Melão Mossoró, refletem na percepção dos seus stakeholders, apresenta consistência com os princípios dos modelos de teóricos de Schwartz e Carroll (2003) e Melo Neto e Froes. Suas ações se pautam por razões econômicas, legais e éticas, no entanto, existe um enraizamento da RSE na dimensão econômica fazendo com que as demais dimensões sejam atingidas ou satisfeitas em uma perspectiva secundaria, quase uma relação causa conseqüência, do melhoramento da dimensão econômica.
Activation of the cGAS-sting Pathway Mediated by Nanocomplexes for Tumor Therapy
Authors: Qian Yuxuan , Cao Shujuan , He Li , Cai Yanfei , Yang Zhaoqi
Published: January 2025

cGAS (cyclic GMP-AMP synthase)-STING (stimulator of interferon genes) pathway is an natural
immune response signaling pathway in the human body that is essential for sensing abnormal DNA aggregation
in the cell. When the cGAS protein senses abnormal or damaged DNA, it forms a second messenger
called cyclic dinucleotide (cGAMP). The cycled dinucleotide will activate the downstream STING protein,
thereby inducing the expression of inflammatory cytokines such as type I interferon, which binds to receptors
on its own cell membrane and ultimately initiates multiple immune response pathways. This signaling pathway
plays an important immune role in antimicrobial and antitumor functions, etc. so the development of
drugs targeting this signaling pathway has important clinical application value. In recent years nanocomplexes
based cGAS-STING signaling pathway activation and inhibition treatments have been gradually developed. In
this review, on the basis of elaborating the main activation mechanism of the cGAS-STING pathway, we further
introduced the nanocomplexes that effectively activate the cGAS-STING pathway, focusing on the composition,
types and applications of the nanocomplexes. In addition, we discussed the key challenges and future
research directions of the way that stimulating the cGAS-STING signaling pathway in the form of nanocomplexes
to activate immuno-tumor therapy. Our work aims to provide a better understanding of the progress of
nanotherapeutics in the cGAS-STING pathway, providing a promising anti-tumor therapeutic strategy.
Synthesis, Characterization and Evaluation of Antimicrobial and Antioxidant Activities of Novel Chalcone Scaffolds
Authors: Mittapalli Sathish Kumar , Parashar Deepesh , S. Roshan , M V Neethu , Mahor Ajay , Gupta Pawan Kumar , Pamu Sagar , Rizwana Iffath
Published: January 2025

Background:

Synthetic antibiotics are often much more potent than natural alternatives.
They can effectively treat serious and life-threatening bacterial infections.

Methods:

The chalcones were synthesized by Claisen-Schmidt condensation and characterized by
FT-IR, 1HNMR, 13CNMR and MS methods. All the compounds underwent computational and invitro
evaluations for antimicrobial and antioxidant properties.

Results:

The docking studies indicated that all the molecules displayed good binding energy with
their selective targets, with 6g and 6h showing the best affinity among them. The antimicrobial test
results showed that the MIC values ranged from 0.4 to 0.9 mg/ml, and compounds 6g and 6h demonstrated
potential for gram-positive bacteria. At the same time, 6k and 6l displayed good inhibition
activity against gram-negative bacteria. Compound 6k showed potential against Candida albicans,
and compound 6l showed potential against Aspergillus Niger. However, compound 6b showed poor
antimicrobial activity. Compounds 6g and 6f also exhibited ferrous ion chelating activity at 28.69
μg/ml and 29.94 μg/ml, respectively.

Conclusion:

Based on the IC50 values, it was found that only compounds 6g and 6f had superior
against oxidation, which was evaluated using EDTA as a reference. The ADMET properties were
analyzed using SwissADME. Furthermore, the lead likeness results showed that 6g exhibited leadlike
characteristics.
Potentiometric Ion-selective Electrode for the Determination of Antazoline in Different Formulations and Biological Fluids Using Biomimetic Receptors
Authors: Hussein Ola G. , Rostom Yasmin , Mahmoud Amr M. , Abdelkawy Mohamed , Rezk Mamdouh R. , Ahmed Dina A.
Published: January 2025

Background:

Traditional analysis techniques usually involve separation and pre-treatment
steps prior to analysis, resulting in time and solvent consumption. In contrast, a potentiometric ion
selective electrode is a simple, environmentally friendly, and cost-effective technique that is used as
an alternative analytical technique, utilizing the efficacy of potentiometric sensors used in stability
research and quality control investigations.

Methods:

An innovative Antazoline selective membrane sensor was constructed and evaluated to
detect Antazoline in its pure form, eye drop formulations, degradation products, and biological fluid.
Sensor fabrication was achieved using potassium tetrakis borate and polyvinyl chloride polymeric
matrix plasticized with 2-nitrophenyl octyl ether and using calix[8]arene (CX8) as an ionophore. A
comparative potentiometric study was implemented using two sensors, one using an ionophore and
the other lacking the ionophore.

Results:

Linear responses of Antazoline were obtained utilizing sensors 1 and 2 in concentration
ranges of 1.0×10-2 to 1.0×10-7 mole/L and 1.0×10-2 to 1.0×10-6 mole/L, correspondingly. Nernstian
slopes of 58.486 and 51.2 mV/decade over pH 8.0 were attainted using 1 and 2 sensors, respectively.

Conclusion:

The proposed method was applied to determine antazoline without any need for any
pretreatment or separation steps in both formulated eye drops Trillerg® sterile ophthalmic solution
and Otrivine- Antistin® Eye Drops as well as in rabbit aqueous humor and the presence of its degradation
products. Estimation of the method's greenness was confirmed using several assessment tools.
Safety and Efficacy of Anlotinib-based Regimen in Patients with Unresectable or Metastatic Bone and Soft-tissue Sarcomas: A Retrospective Institutional Study
Authors: Pang Lina , Zhang Shengli , Wang Liye , Gong Shuai , He Wei
Published: January 2025

Background:

Anlotinib has demonstrated durable clinical benefits in patients with unresectable or
metastatic bone and soft-tissue sarcomas.

Methods:

92 patients treated with chemotherapy combined with or without anlotinib were collected and analyzed.
The objective response rate (ORR) and disease control rate (DCR) were analyzed. Long-term survival was assessed
using the Kaplan-Meier method, including median progression-free survival (mPFS) and overall survival
(mOS).

Results:

Liposarcoma, synovial sarcoma, and rhabdomyosarcoma were the primary pathological subtypes of the
92 patients. The median age was 46 (range, 11–75) years. The ORR and DCR of the anlotinib-chemotherapy
combination used as first-line therapy were 31.9% and 85.1%, respectively. However, the ORR and DCR were
only 6.7% and 57.8% in the chemotherapy alone, respectively. Compared with the chemotherapy group, improvements
were observed in the mPFS and mOS with anlotinib-based regimen (mPFS, 8.3 vs. 3.0 months; mOS,
59.0 vs. 22.0 months). Anlotinib-associated adverse events were well tolerated and mainly occurred in grades I
and II. New anlotinib-related adverse reactions were not noted.

Conclusion:

Anlotinib-based regimen as a first-line therapy showed a positive effect on the treatment of unresectable
or metastatic BSTSs. The anlotinib-associated adverse events were minor and well tolerated.
The embodiment of Qian Zhongshu’s Guan Zhui Bian in an internet novel: Xuanxue and metaphor
Authors: Wang Aiqing
Published: January 2025

As an iconic intellectual, novelist, translator and poet in the 20th century, 钱钟书 Qian Zhongshu (1910-1998) was not only celebrated for literary aptitude, epitomised by his chef-d’oeuvre 围城 Wei Cheng ‘Fortress Besieged’ (serialised 1946-1947), but also for his unrivalled erudition, multilingualism and critical acumen. Qian Zhongshu was versed in Chinese and Western studies, encompassing literature, philosophy, psychology, history, aesthetics, etc. Qian Zhongshu’s commendable scholarly research can be exemplified by an encyclopaedic masterpiece entitled 管锥编 Guan Zhui Bian ‘Limited Views: Essays on Ideas and Letters’ (1979), which is constituted of a prodigious amount of reading notes and essays written in concise, recondite Classical Chinese. Notwithstanding its self-deprecating title, Guan Zhui Bian has attained critical plaudits. In a web-based time-travel novel 上品寒士 Shangpin Han Shi ‘A Top-Ranked Impoverished Scholar’ (2009-2011) composed by a writer pseudonymised as 贼道三痴 Zeidaosanchi, the author deployed elements from Guan Zhui Bian, which defies the stereotype that male-authored and male-oriented online narratives are prone to be ‘feel-good writing’ marked by 意淫 yi yin ‘lust of the mind; mental pornography’. To be more specific, the author drew on Qian Zhongshu’s elaboration of 玄学 xuanxue (Lit. ‘learning in the profound’) and analyses of metaphor.
Awareness of Sexual Partner’s HIV Status Among Men Who Have Sex With Men in China: Cross-Sec. tional Survey Study
Authors: Ma Qian , Jiang Tingting , Chen Wanjun , Jiang Shaoqiang , Zheng Jinlei , Wang Hui , He Lin
Published: January 2025

Background

Men who have sex with men (MSM) constitute a significant proportion of individuals living with human immunodeficiency virus. Over the past few years, China has implemented various strategies aimed at increasing the rate of HIV testing and reducing HIV transmission among MSM. Among these, the disclosure of HIV serostatus is an effective prevention strategy.

Objective

This study aimed to assess HIV serostatus disclosure and identify factors associated with awareness of sexual partners’ HIV status among MSM to provide a scientific basis for promoting HIV testing and reducing HIV transmission.

Methods

A cross-sectional study based on a large-scale web-based survey was conducted among MSM in Zhejiang province, China, between July and December 2023. MSM who were HIV-negative or had an unknown HIV status were recruited from the Sunshine Test, a web-based platform that uses location-based services to provide HIV prevention services. Participants were required to complete a questionnaire on demographic characteristics, sexual behavior, rush popper use, awareness of sexual partners’ HIV status, and knowledge of pre-exposure prophylaxis (PrEP) and postexposure prophylaxis (PEP). A multinomial regression model was used to identify the factors associated with awareness of sexual partners’ HIV status.

Results

A total of 7629 MSM participated in the study, with 45.2% (n=3451) being aware, 35.4% (n=2701) being partially aware, and 19.4% (n=1477) being unaware of their sexual partner’s HIV status. The multinomial logistic regression analysis revealed the following results. Compared to those who were unaware of their sexual partner’s HIV status, participants who were students (adjusted odds ratio [aOR] 1.43, 95% CI 1.09‐1.86), had a monthly income of more than US $1400 (aOR 1.36, 95% CI 1.03‐1.80), had insertive anal sex (aOR 1.35, 95% CI 1.12‐1.63), had only male sexual partners (aOR 1.53, 95% CI 1.28‐1.82), had 1 sexual partner in the past 3 months (aOR 2.36, 95% CI 2.01‐2.77), had used condoms for the past 3 months (aOR 1.72, 95% CI 1.33‐2.22), had frequently used rush poppers in the past 3 months (aOR 2.27, 95% CI 1.81‐2.86), were aware of HIV PrEP (aOR 2.04, 95% CI 1.68‐2.48), were aware of HIV PEP (aOR 1.69, 95% CI 1.39‐2.06), used mail reagent self-testing (aOR 1.19, 95% CI 1.04‐1.36), and had previously undergone HIV testing (aOR 1.40, 95% CI 1.16‐1.69) were associated with increased odds of being aware of their sexual partner’s HIV status.

Conclusions

Overall, 45.2% of MSM who were HIV-negative or had an unknown status were aware of their sexual partners’ HIV status in China. We suggest strengthening targeted interventions through web-based platforms and gay apps to promote the disclosure of HIV serostatus and reduce HIV transmission among MSM.
On the Protection of Reliance in Administrative Practice
Authors: Xiangkai Jin
Published: January 2025

In the field of administrative law, protection of reliance has always been a hot topic of controversy, and its development also reflects the development and change of administrative law to a certain extent. It plays an important role in various administrative behaviors such as administrative litigation, administrative penalty, administrative compensation, as well as on land and at sea. The number of cases in which our courts have utilized reliance protection for interpretation and sentencing in actual trials has also been increasing. However, the principle is to grasp the overall level, the actual use of the principle will still be different according to different cases, and there is a difference in the order of priority. How to correctly identify the protection of reliance in different administrative cases, and the use of it has become the key. Therefore, the case of administrative agreement is taken to analyze and explore the protection of reliance in law enforcement.
The Conflict and Coordination between Intellectual Property Law and Human Rights Law in the Context of Globalization and Digitization
Authors: Tan Siyu
Published: January 2025

In the current era of digitalization and globalization, both intellectual property law and human rights law are facing unprecedented challenges and opportunities. In the process of constantly seeking the balance between the two, there are inevitably multiple conflicts, such as excessive protection of intellectual property rights that may limit the freedom of knowledge acquisition guaranteed by human rights law, and human rights demands that may also impact the exclusivity of intellectual property rights. It is necessary to explore ways to coordinate the conflicts between them in order to build a more harmonious and sustainable socio-economic and cultural environment. This article aims to analyze in depth the conflict manifestations and root causes of these two types of laws in the context of digitization and globalization, and actively explore feasible strategies for coordinating conflicts. By elaborating on the concepts and connotations of the two, analyzing their conflicts in multiple aspects such as balancing interests and acquiring knowledge resources, and exploring various strategies for coordinating conflicts in this new era environment, including the improvement of legal systems and the enhancement of public awareness of rights and interests, in order to promote the harmonious coexistence of the two under the legal framework of modern society and jointly promote social development.
Integración de mujeres, jóvenes y docentes en el contexto político chiapaneco, 1925-1945
Authors: Arce Moguel Mario Heriberto
Published: January 2025

El artículo tiene como objetivo analizar y describir el proceso por medio del cual las agrupaciones de jóvenes, mujeres y docentes se integraron como elementos activos en el sistema político de Chiapas, México, entre 1925 y 1945. La asimilación de estas agrupaciones en las estructuras de control favoreció la operación del modelo corporativo y afianzó los lazos entre la Presidencia de la República y las fuerzas locales. Se recurrió al análisis de circulares, notas hemerográficas, cartas, oficios, comunicados, telefonemas y editoriales. A partir de la interpretación de las fuentes primarias mencionadas, se plantea la consolidación de prácticas que ayudaron para que sujetos procedentes de las filas del partido oficial permanecieran en las principales posiciones de poder, lo que benefició la operatividad del sistema político.