bluuebunny/crossref_metadata_2025 huggingface dataset:
Основное общее образование у детей, использующих систему альтернативной коммуникации PECS
Authors: Андрусенко Владислав М. , Римская Татьяна О.
Published: March 2023

Многими авторами и их исследованиями давно определено, что система альтернативной коммуникации PECS (Picture exchange communication system) оказывает исключительно позитивное влияние на обучение детей с определенными нарушениями здоровья, в том числе, на уровне основного общего образования. В исследовании представлены материалы теоретического исследования и обзора трудов об эффективности использования системы альтернативной коммуникации PECS. Особое внимание было обращено на эмпирические исследования педагогов и психологов в данной области для дальнейшего обобщения результатов по вопросу эффективного использования системы альтернативной коммуникации PECS для учащихся на уровне основного общего образования. Автор определил и обосновал 6 фаз системы альтернативной коммуникации PECS для развития детей с расстройством аутистического спектра или с нарушениями речи. В статье представлен новый взгляд на проблему - система работы по формированию альтернативной коммуникации учащихся с расстройством аутистического спектра или с нарушениями речи представляет собой совместную работу с родителями, так в дальнейшем формы и содержание работы с учащимся определяется совместно с родителями. Новизна исследования заключается в том, что автор рассматривает систему альтернативной коммуникации PECS – систему общения, при которой используются методика обмена карточкам для детей с расстройствами аутистического спектра или с нарушениями речи. Впервые исследовано, что система альтернативной коммуникации PECS позволяет снизить уровень агрессивности у детей с речевыми нарушениями или нарушением аутистического спектра, которые не могут сообщить о своих потребностях и желаниях. Автор пришел к выводу, что система альтернативной коммуникации PECS позволяет ребенку с расстройством аутистического спектра или с нарушениями речи передать свое желание или потребность через картинки.
Metallopeptidases as Key Virulence Attributes of Clinically Relevant
Protozoa: New Discoveries, Perspectives, and Frontiers of Knowledge
Authors: dos Santos André Luis Souza , Tasca Tiana , Vargas Rigo Graziela , Gomes Cardoso Fernanda , Bongiorni Galego Giulia , da Rosa Deisiane Fernanda
Published: March 2023

This article provides a comprehensive review of several subclasses of metallo-type peptidases
expressed by the main clinically relevant protozoa, including Plasmodium spp., Toxoplasma
gondii, Cryptosporidium spp., Leishmania spp., Trypanosoma spp., Entamoeba histolytica, Giardia
duodenalis, and Trichomonas vaginalis. These species comprise a diverse group of unicellular eukaryotic
microorganisms responsible for widespread and severe human infections. Metallopeptidases, defined
as hydrolases with activity mediated by divalent metal cation, play important roles in the induction
and maintenance of parasitic infections. In this context, metallopeptidases can be considered veritable
virulence factors in protozoa with direct/indirect participation in several key pathophysiological
processes, including adherence, invasion, evasion, excystation, central metabolism, nutrition, growth,
proliferation, and differentiation. Indeed, metallopeptidases have become an important and valid target
to search for new compounds with chemotherapeutic purposes. The present review aims to gather updates
regarding metallopeptidase subclasses, exploring their participation in protozoa virulence as well
as investigating the similarity of peptidase sequences through bioinformatic techniques in order to discover
clusters of great relevance for the development of new broad antiparasitic molecules.
Prominent Targets for Cancer Care: Immunotherapy Perspective
Authors: Patel Mehul , Thakkar Aashka , Bhatt Priya , Shah Umang , Patel Ashish , Solanki Nilay , Patel Swayamprakash , Patel Sandip , Gandhi Karan , Patel Bhavesh
Published: March 2023

Objective:

Recent scientific advances have expanded insight into the immune system and
its response to malignant cells. In the past few years, immunotherapy has attained a hallmark for
cancer treatment, especially for patients suffering from the advanced-stage disease. Modulating the
immune system by blocking various immune checkpoint receptor proteins through monoclonal antibodies
has improved cancer patients' survival rates.

Methods:

The scope of this review spans from 1985 to the present day. Many journals, books, and
theses have been used to gather data, as well as Internet-based information such as Wiley, PubMed,
Google Scholar, ScienceDirect, EBSCO, SpringerLink, and Online electronic journals.

Key Findings:

Current review elaborates on the potential inhibitory and stimulatory checkpoint
pathways which are emerged and have been tested in various preclinical models, clinical trials, and
practices. Twenty-odd such significant checkpoints are identified and discussed in the present work.

Conclusion:

A large number of ongoing studies reveal that combination therapies that target more
than one signaling pathway may become effective in order to maximize efficacy and minimize toxicity.
Moreover, these immunotherapy targets can be a part of integrated therapeutic strategies in
addition to classical approaches. It may become a paradigm shift as a promising strategy for cancer
treatment.
The Radiological Evaluation of the Anatomy of the Alveolar Antral Artery and
the Lateral Wall Thickness Using Cone-beam Computed Tomography: A
Retrospective Study
Authors: Zhou Qiman , Qiao Feng , Zhu Dongwang
Published: March 2023

Objectives:

Study aims to assess the position and route of the alveolar antral artery and the lateral wall thickness of the maxillary sinus using cone-beam
computed tomography (CBCT), reducing the risk of complications and improving the success rate of surgery.

Materials and Methods:

This study included CBCT scans from 238 patients. The detection diameter of AAA and distance of the lower border of AAA to the maxillary
sinus floor at the first premolar, second premolar, first molar, and second molar locations were evaluated. The route of AAA was observed with
novel classification. Furthermore, the distance from the maxillary sinus floor to the alveolar crest at four posterior tooth locations was measured
respectively. Moreover, the lateral wall thickness at four locations was assessed. Data were subjected to statistical analysis.

Results:

AAA was observed in 62.18% of all sinuses. The mean diameter was 0.99±0.21 mm, with significant differences within gender. Half of the route
of AAA was intrasinus intraosseous type. The mean distance between the maxillary sinus floor and AAA was 8.00±2.68 mm, with a significant
difference between dentate and edentulous status at the first molar location. Distance from the sinus floor to the alveolar ridge crest in edentulous
status negatively correlated with the distance from the sinus floor to AAA at the first molar location. The mean thickness of the lateral wall was
2.03±0.91 mm, and the difference in thickness between males and females at the four locations was statistically significant.

Conclusion:

Intrasinus-intraosseous type, is the most common route. Special care should be taken at the first molar location during a lateral window sinus floor
elevation. CBCT is highly recommended to before lateral wall maxillary sinus floor elevation.
Anti-inflammatory Activity of Pyrazole Analogues Deduced from Bioactive
Piperine: Synthesis, In silico, and In vitro Evaluation
Authors: Mathew Lilbet , sankaranarayanan Murugesan , Kaliappan Ilango
Published: March 2023

Background:

Around ten novel pyrazoline and pyrazolidine derivatives were designed and
synthesized by the condensation of piperine, hydrazine hydrate, phenylhydrazine, aromatic carboxylic
acid, and ethanol.

Methods:

The synthesized compounds (2, 3, 4a-d, and 5a-d) were characterized by FTIR, 1HNMR,
mass spectral, and elemental analysis. Pharmacokinetic, physicochemical, drug-likeness, and medicinal
chemistry friendliness parameters were also predicted by in silico methods.

Results:

Furthermore, compounds were screened for in vitro anti-inflammatory activity by the HRBC
membrane stabilization method using diclofenac sodium as the standard drug. The tested compounds
showed moderate anti-inflammatory activity compared to the standard drug. The molecular docking
studies of significantly active (4d) and least active compounds (5d) were also carried out in the active
sites of an arachidonate-12-lipoxygenase target in order to study the putative binding pattern of the
study compounds.

Conclusion:

According to the findings of this study, further lead identification as well as lead optimization
techniques will be required in the near future in order to get potent analogues.
Anti-inflammatory Effects of Umbilical Cord Mesenchymal Stem Cell and
Autologous Conditioned Serum on Oligodendrocyte, Astrocyte, and
Microglial Specific Gene in Cuprizone Animal Model
Authors: Alavi Omid , Alizadeh Aliakbar , Dehghani Farzaneh , Alipour Hamed , Tanideh Nader
Published: March 2023

Background:

Inflammation, myelin loss, astrocytosis, and microgliosis are pathological signs
of the autoimmune and demyelinating disease known as multiple sclerosis (MS). Axonal and neuronal
degenerations have basic molecular pathways. The remyelination process can be influenced by the secretome
of mesenchymal stem cells due to their capacity for immunomodulation, differentiation, and neuroprotection.
Microglial cells are divided into two subgroups: M1 and M2 phenotypes. A crucial component
of the microglial function is the colony stimulating factor 1 receptor (CSF1R). We aimed to evaluate the
immunomodulating effects of secretome and conditioned serum on the microglial phenotypes and improvement
of demyelination in a cuprizone model of MS.

Methods:

The study used 48 male C57BL/6 mice, which were randomly distributed into 6 subgroups (n =
8), i.e., control, cuprizone, MSC (confluency 40% and 80%) secretome group, and blood derived conditioned
serum (autologous and humanized). The animals were fed with 0.2% cuprizone diet for 12 weeks.
Supplements were injected into the lateral tail vein using a 27-gauge needle every 3 days 500 μl per injection.

Results:

At 14 days after transplantation, animals from each group were sacrificed and analyzed by Real
time PCR. The results showed that the administration of MSC secretome can efficiently reduce expression
of pro-inflammatory cytokines (IL-1, IL6 and TNF-α) in the corpus callosum; also, conditioned serum
downregulated IL-1. Moreover, the oligodendrocyte-specific gene was upregulated by secretome
and conditioned serum treatment. Also, the expression of microglial- specific gene was reduced after
treatment.

Conclusions:

These findings demonstrated that the secretome isolated from MSCs used as a therapy decreased
and increased the M1 and M2 levels, respectively, to control neuroinflammation in CPZ mice. In
conclusion, the current study showed the viability of devising a method to prepare suitable MSCs and
secreted factor to cure neurodegenerative diseases, as well as the capability of regulating MSC secretome
patterns by manipulating the cell density.
Erianin as a Promising Novel Agent in the Treatment of Neuroblastoma: The Anticancer
Effects and Underlying Molecular Mechanisms
Authors: Kocoglu Sema Serter , Seçme Mücahit , Sunay Fatma Bahar
Published: March 2023

Background:

Erianin is an active dibenzyl compound isolated from Dendrobium officinale and Dendrobium
chrysotoxum and there are very few studies on molecular mechanisms and drug targets of erianin. In addition, there is
no study investigating the anti-cancer effect of erianin on neuroblastoma cells.

Objective:

The aim of the study is to investigate the anticancer effect of erianin and the underlying mechanism of this
effect on SH-SY5Y cells.

Methods:

The effects of erianin on cell viability, invasion and migration were determined by XTT, matrigel chamber
and wound healing evaluation, respectively. Expression changes of miRNAs (microRNA) and apoptosis-related genes
were evaluated by RT-PCR, and the apoptosis rate was supported by Annexin V evaluation.

Results:

Erianin significantly decreased cell proliferation, invasion and migration. Erianin administration caused apoptosis
by significantly increasing caspase-7, FADD (Fas-associated protein with death domain), BID (BH3 Interacting
Domain Death Agonist) and DR5 (Death receptor 5) gene expressions. While the rate of total apoptotic cells was 45.35
± 6.80% in SH-SY5Y cells treated with erianin, it was 0.133 ± 0.05% in the control group (p = 0.000). In addition,
erianin administration significantly decreased the expressions of hsa-miR-155-5p (p = 0.014) and hsa-miR-223-3p (p =
0.004). Also, our study demonstrated for the first time the relationship between erianin and mi-RNAs in a cancer cell.

Conclusion:

Our study suggests that erianin may be a natural, safe and easily accessible drug candidate that can be
used in the treatment of neuroblastoma.
Cancer-associated Fibroblast-derived Extracellular Vesicles Mediate
Immune Escape of Bladder Cancer via PD-L1/PD-1 Expression
Authors: Feng Rui , Li Zhongxing , Ge Guangcheng , Wang Chenghao , Jia Yuejun , Ouyang Jun
Published: March 2023

Objective:

Bladder cancer (BCa) is a malignant urological tumor with a high preva-lence and poor prognosis. Extracellular vesicles (EVs) are increasingly becoming current hotspots owing to their involvement in cancer progression. This paper probed into the action of cancer-associated fibroblast-derived EVs (CAF-EVs) in the immune escape of BCa.

Methods:

CAFs were identified by immunofluorescence. EVs were extracted from CAFs via ultracentrifugation and later characterized. BCa cells (T24 cell line) were co-cultured with CD8+ T cells and then treated with CAF-EVs. The uptake of EVs by T24 cells was examined by con-focal laser microscopy. T24 cell apoptosis and invasion were assessed using flow cytometry and invasion assay. CD8+ T cell proliferation was evaluated using CFSE staining. The levels of cy-tokines (IFN-γ, IL-2, and TNF-α) were measured by ELISA. PD-L1 and PD-1 levels were deter-mined utilizing RT-qPCR and flow cytometry. BCa mouse models were established to identify the effect of CAF-EVs on BCa progression in vivo.

Results:

CAF-EVs decreased apoptosis and enhanced invasion of T24 cells, reduced prolifera-tion of CD8+ T cells, and diminished levels of IFN-γ, IL-2, and TNF-α secreted by CD8+ T cells. CAF-EVs promoted the immune escape of T24 cells by carrying PD-L1. Downregulation of PD-L1 expression in T24 cells or EVs partially counteracted the promotion of CAF-EVs on immune escape by reducing the binding of PD-L1 and PD-1. Additionally, CAF-EVs raised tumor volume and weight, upregulated PD-L1 expression, and weakened CD8+ T cell infiltration in BCa mice.

Conclusion:

CAF-EVs facilitate the immune escape of BCa by upregulating PD-L1/PD-1.
Dos cadernos amarelos aos arquivos infinitos: Metamorfoses do trabalho docente na cultura digital
Authors: Oliveira Evandro Salvador Alves , Cecílio Sálua
Published: March 2023

O mundo do trabalho tem sido significativamente reorganizado na cultura do capitalismo global e flexível e vem requerendo um novo perfil de trabalhador. Assim, também o trabalho docente tem sido modificado em razão das metamorfoses simultâneas ocorridas a partir dos constantes movimentos no âmbito da economia, educação, política, e até mesmo em função da cultura digital, que afetam a vida e a profissão dos professores. Dado esse novo panorama social e cultural, aqui objetiva-se discutir aspectos que envolvem a transição “dos cadernos amarelos aos arquivos infinitos”, propiciada, sobretudo, pela cultura digital e seu potencial de mudança no trabalho docente. O foco é compreender as principais mudanças ocorridas no trabalho de um grupo de docentes do ensino superior de um Centro Universitário do interior de Goiás, Brasil. Participaram da pesquisa de campo, como entrevistados, 15 docentes. Os resultados obtidos foram submetidos a análise de conteúdo temática para a organização e tratamento das informações. Entre as principais conclusões, tem-se que as tecnologias digitais interferem nos processos, natureza, dimensões e desenvolvimento do trabalho docente no ensino superior, provavelmente pelo fato de elas não se caracterizarem como aspectos invisíveis no processo de trabalho na cultura digital.
Crenças de autoeficácia em professores referentes aos saberes docentes para a educação inclusiva
Authors: Nozi Gislaine Semcovici , VITALIANO CELIA REGINA
Published: March 2023

Crenças de autoeficácia em professores se referem ao quanto eles se julgam capazes de implementar ações em sala de aula com o objetivo de afetar a autoeficácia, a motivação e o desempenho dos alunos. Tendo em vista a importância deste constructo motivacional em professores, esta pesquisa teve por objetivo: investigar as crenças de autoeficácia em professores regentes de classe comum do Ensino Fundamental I para a execução de ações pedagógicas relacionadas aos saberes procedimentais indicados pela literatura para favorecer o processo de inclusão de alunos com Necessidades Educacionais Especiais (NEE). O método adotado foi a pesquisa de levantamento. A coleta dos dados foi realizada por meio de entrevistas semiestruturadas e os dados foram organizados em uma categoria e 10 subcategorias. Como resultados identificamos que as professoras participantes do estudo apresentaram crenças de autoeficácia mais positivas para: desenvolver um clima emocional e afetivo positivo em sala de aula em relação aos alunos com NEE; atuar de forma colaborativa com outros profissionais; avaliar e organizar o espaço físico da sala de aula; e identificar as dificuldades dos alunos com NEE. E apresentaram crenças de autoeficácia insuficientes para avaliar a aprendizagem dos alunos com NEE e organizar atividades pedagógicas inclusivas. Os resultados apontam que o domínio de saberes procedimentais para a educação inclusiva interfere na crença de autoeficácia de professores para trabalhar com alunos com NEE e que a crença da autoeficácia dos professores influencia no modo como eles organizam a prática pedagógica junto aos alunos com NEE.
Thermal profile analysis in simulation of the initial stage of synthesis of Cu-Au nanoparticles from the gas phase
Authors: Gafner Yu. Ya.  , Ryzhkova D.A.
Published: March 2023

The production of particles from the gas phase is one of the main physical methods for the synthesis of nanostructured materials, the obvious advantages of which include good control of the target composition of the resulting nanomaterial. However, the determination of clear dependences between the initial parameters of experimental setups and the size of nanoparticles is not an easy task, requiring a detailed study of the processes of formation, growth, and agglomeration of nanoclusters. Another problem is that metal nanoparticles of identical chemical composition and size can be in different structural states or have different levels of defects. The processes underlying the formation of the structure of such nanoparticles are also not completely clear, especially at the very initial stage of synthesis from the moment of decomposition of precursors to the formation of primary stable nuclei. Therefore, in the presented work, the molecular dynamics method was used to simulate the process of synthesis of Cu-Au nanoclusters of various target compositions from the high-temperature gas phase. Based on the data obtained, conclusions were drawn about the main stages of the evolution of the model system. It is shown that the initial stage of synthesis consists of five different stages, gradually leading to the formation of primary spherical Cu-Au binary alloy nanoparticles with a clear extrusion of gold atoms to the surface. Keywords: nanotechnology, synthesis, nanopowders, computer simulation, tight binding, nanoparticles, copper, gold.
Surface crystallization of amorphous Fe-=SUB=-73.8-=/SUB=-Si-=SUB=-13-=/SUB=-B-=SUB=-9.1-=/SUB=-Cu-=SUB=-1-=/SUB=-Nb-=SUB=-3.1-=/SUB=- and Fe-=SUB=-77.5-=/SUB=-Si-=SUB=-13.5-=/SUB=-B-=SUB=-9-=/SUB=- microwires
Authors: Fuks A. A.  , Abrosimova G. E.  , Aksenov O.I.  , Aronin A. S.
Published: March 2023

Amorphous microwires of Fe73.8Si13B9.1Cu1Nb3.1 andFe77.5Si13.5B9 composition fabricated by the Ulitovsky--Taylor method were studied. The samples with the glass shell removed were heated at temperatures of 753 K and 703 K for 20 min, afterwards, their structure was examined using X-ray diffraction. Subsequently, the thermally treated samples were chemically etched and X-ray diffraction study of the structure was again carried out. Experimental results on the predominant crystallization of near-surface regions were discussed assuming that mechanical stresses affect the nucleation and growth of nanocrystals. Keywords: amorphous materials, stress distribution, nanocrystallization, X-ray diffraction.
Effect of the thickness on electrical resistance of thin diamond-like carbon coatings on silicon substrate
Authors: Zur I. A.  , Shmanay Y. E.  , Fedotova J. A.  , Kharchanka A. A.  , Movchan S. A.
Published: March 2023

The relationship between sp2/sp3-hybridizations ratio of atomic bonds in diamond-like carbon ( DLC --- Diamond-Like Carbon) and its electrical resistivity for coatings with a thickness in the range 22-70 nm prepared by vacuum arc deposition on silicon substrate of the KDB-8 brand has been established. It is established, that an increase in the coating thickness from 22 to 70 nm is accompanied by a decrease in the specific transverse electrical resistance of samples from 17 to 2 GΩ·m. This effect is explained by an increase in the proportion of carbon atoms with sp2-hybridization of electronic orbitals from 86 to 91%, which leads to the appearance of an additional number of π-bonds. A mathematical model, describing the spatial distribution of current when measuring transverse I-V characteristic, has been developed. The results obtained will be useful in creating resistive layers on the electrodes of gas-discharge detectors of charged particle to limit the amount of current in the event of rare spark discharges inside them caused by the registration of random highly ionizing particles. Keywords: ( DLC), electrical properties of thin films, hybridization of electronic orbitals, Raman scattering, I-V characteristic.
Memory effects and nonlinear electrical conductivity of doped perovskite-like lanthanum-strontium ferrite, La-=SUB=-0.5-=/SUB=-Sr-=SUB=-0.5-=/SUB=-Fe-=SUB=-0.75-=/SUB=-Al-=SUB=-0.2-=/SUB=-Ni-=SUB=-0.05-=/SUB=-O-=SUB=-3-delta-=/SUB=-
Authors: Petukhova E.A.  , Kharton V.V.  , Kveder V.V.
Published: March 2023

Analysis of the existence of memory phenomena in model heterostructures based on doped ferrite La0.5Sr0.5Fe0.75Al0.2Ni0.05O3-delta with a perovskite structure has been carried out. It was demonstrated that one 5-10 μm thick ferrite layer sandwiched between Pt and Ni electrodes exhibits an analog memristor behavior. Under positive polarity, this heterostructure shows a smooth increase in electrical conductivity, with an opposite effect under negative polarity. Such phenomena are presumably associated with changing local concentrations of oxygen vacancies due to their drift in the electric field. Since lanthanum-strontium ferrites are sufficiently tolerant with respect to oxygen non-stoichiometry variations, no dendrite growth due to reductive decomposition is observed. The current vs. voltage dependencies display a strong nonlinearity resulting from the Poole--Frenkel effect, namely, a decrease in the activation energy of electron holes trapped on oxygen vacancies. In addition to the Poole--Frenkel effect, pre-exponential factor of the conductivity vs. temperature dependence also increases under electric field, indicating an increase in the effective electron-hole mobility. Keywords: perovskite, lanthanum-strontium ferrites, memory effects, nonlinear electronic transport, memristors.
Manifestation of the exchange interaction of electrons separated by a potential barrier in double quantum wells in the Kerr effect
Authors: Degoev M. M.  , Afanasiev M. M.  , Kalevich V. K.  , Kavokin K. V.  , Kozyrev N. V.  , Karczewski G.  , Kusrayev Yu. G.
Published: March 2023

In tunnel-coupled quantum wells of different widths, it was found that the spin dynamics arising from resonant pulsed optical pumping of an exciton in the narrow well includes the dynamics of electron spin polarization in the wide well, although the electron level in the wide well is 55 meV lower than the electron level in the narrow well. An analysis of the obtained results showed that the observed effect is caused by the exchange interaction of spin-polarized electrons in the wide well with exciton states in the narrow well. Keywords: semiconductor nanostructures, exchange interaction, Kerr effect.
Nonlinearity and harmonics of the magnetic susceptibility of a Co-=SUP=-2+-=/SUP=- single-ion magnet in the paramagnetic region above the magnetic ordering temperature
Authors: Koplak O. V.  , Dvoretskaya E. V.  , Kunitsyna E. I.  , Morgunov R. B.
Published: March 2023

In single-ion complexes based on Co2+ ions, the second and third harmonics of the magnetic susceptibility were found at temperatures of 2-4 K, which exceed the Neel temperature. The maxima of the second and third harmonics of the magnetic susceptibility are observed at a frequency of ~1 Hz, at which the maximum of the first harmonic is observed in a field of 3.2 kOe. An analysis of the dependences of the second and third harmonics of the magnetic susceptibility on the field and temperature showed that the nonlinearity arises as a result of the formation of a spin glass state at temperatures slightly higher than the Neel temperature. In this state, there is no long-range spin order, but there are spin clusters in the spin glass state. The spin-glass state in a compound with a Co2+ ion with a high magnetic anisotropy is unusual in that the exchange interaction is much smaller than the single-ion anisotropy energy. Keywords: molecular magnets, nonlinear magnetic susceptibility, nanostructures, spin dynamics, spin glass.
Associations between Health-Related Behaviours, Well-Being, and Academic Performance of Secondary School Students with Special Educational Need: A Secondary Analysis
Authors: Almobayed Shikah , Smith Andrew
Published: March 2023

Health-related behaviours (HRBs) have been considered one of the most critical public health issues, especially for those with special educational needs (SEN). Previous research suggests that health-related behaviours are highly likely to impact well-being and academic achievement. Diet is a crucial health-related behaviour that needs to be investigated along with factors such as sleep and exercise. The present study used data from the Cornish Academies Project, and secondary analyses were conducted to investigate associations between health-related behaviour and well-being and academic performance of secondary students with SEN. The current study sample was 308 students with SEN (mean age, 13.5 years, SD 1.44 years). The study was longitudinal, with time points 6 months apart, and a multivariate design with data from three academies in Cornwall, United Kingdom. The Diet and Behaviour Scale (DABS) measured diet and lifestyle (physical activity, sleep, and general health). Logistic regressions on the time one data showed a significant relationship between good general health and long sleep, eating healthy foods, and avoiding junk food. High exercise and high attendance decreased the likelihood of low attainment. Long sleep was associated with better conduct at time one and time two. There was a significant association between high consumption of healthy foods and good general health and better educational attainment at time two. Longitudinal cross-lagged analyses showed that high tea and high total weekly caffeine consumption at time one were associated with anxiety at time two. In addition, high cola consumption at time one was associated with high depression at time two. Findings from the current study increase our knowledge regarding associations between HRB and well-being, and academic performance in secondary school pupils with SEN, though the results need to be explored further to determine the precise nature of the relationship.
Early-Level Abnormal Breathing Detection System Using Digital Stethoscope with Deep Learning (Preprint)
Authors: Binus Group Suryadiputra , Haryanto Ahyo
Published: March 2023

BACKGROUND

Respiratory disease is one of the leading causes of death on a global scale. Early diagnosis is crucial in detecting health conditions through breathing. However, manual examination using analog stethoscopes requires high levels of medical skills.

OBJECTIVE

It is imperative to develop digital stethoscopes capable of detecting breathing abnormalities.

METHODS

Therefore, this research applied deep learning to the digital stethoscope for abnormal breathing classification. It used a combination of several feature extraction techniques, including Mel-frequency Cepstral Coefficients (MFCC), Chroma Short-Time Fourier Transform (STFT), Mel Spectrogram, Spectral Contrast, and Tonnal Centroid (Tonnetz) and Convolutional Neural Network (CNN). Before the combination, the average value of each feature extraction was obtained to ensure a more valid result.

RESULTS

This model was trained and tested on the ICBHI 2017 Respiratory Sound Database using a categorical cross-entropy loss compilation with the Adam optimizer. Furthermore, the training was conducted using 100 epochs with a batch size of 200 and a testing ratio of 20%, which yield the best result with an accuracy rate of 94.02%. The macro average accuracy measurement results indicated a precision, recall, and f1-score of 61%, 55%, and 55%, respectively.

CONCLUSIONS

In contrast, the weighted average shows a precision, recall, and f1-score of 94%, 94%, and 94% with a support, cross-validation accuracy, and standard deviation of 184, 83%, and 3%.

CLINICALTRIAL

None.
This is test ms 6 march. (Preprint)
Authors: Account Developer
Published: March 2023

UNSTRUCTURED

this is test ms 6 march
The Impact of Point-of-Care Testing for Influenza on Antimicrobial Stewardship (PIAMS) in UK Primary Care: Protocol for a Mixed Methods Study (Preprint)
Authors: Hoang Uy , Williams Alice , Smylie Jessica , Aspden Carole , Button Elizabeth , Macartney Jack , Okusi Cecilia , Byford Rachel , Ferreira Filipa , Leston Meredith , Xie Charis Xuan , Joy Mark , Marsden Gemma , Clark Tristan , de Lusignan Simon
Published: March 2023

BACKGROUND

Molecular point-of-care testing (POCT) used in primary care can inform whether a patient presenting with an acute respiratory infection has influenza. A confirmed clinical diagnosis, particularly early in the disease, could inform better antimicrobial stewardship. Social distancing and lockdowns during the COVID-19 pandemic have disturbed previous patterns of influenza infections in 2021. However, data from samples taken in the last quarter of 2022 suggest that influenza represents 36% of sentinel network positive virology, compared with 24% for respiratory syncytial virus. Problems with integration into the clinical workflow is a known barrier to incorporating technology into routine care.

OBJECTIVE

This study aims to report the impact of POCT for influenza on antimicrobial prescribing in primary care. We will additionally describe severe outcomes of infection (hospitalization and mortality) and how POCT is integrated into primary care workflows.

METHODS

The impact of POCT for influenza on antimicrobial stewardship (PIAMS) in UK primary care is an observational study being conducted between December 2022 and May 2023 and involving 10 practices that contribute data to the English sentinel network. Up to 1000 people who present to participating practices with respiratory symptoms will be swabbed and tested with a rapid molecular POCT analyzer in the practice. Antimicrobial prescribing and other study outcomes will be collected by linking information from the POCT analyzer with data from the patient’s computerized medical record. We will collect data on how POCT is incorporated into practice using data flow diagrams, unified modeling language use case diagrams, and Business Process Modeling Notation.

RESULTS

We will present the crude and adjusted odds of antimicrobial prescribing (all antibiotics and antivirals) given a POCT diagnosis of influenza, stratifying by whether individuals have a respiratory or other relevant diagnosis (eg, bronchiectasis). We will also present the rates of hospital referrals and deaths related to influenza infection in PIAMS study practices compared with a set of matched practices in the sentinel network and the rest of the network. We will describe any difference in implementation models in terms of staff involved and workflow.

CONCLUSIONS

This study will generate data on the impact of POCT testing for influenza in primary care as well as help to inform about the feasibility of incorporating POCT into primary care workflows. It will inform the design of future larger studies about the effectiveness and cost-effectiveness of POCT to improve antimicrobial stewardship and any impact on severe outcomes.

INTERNATIONAL REGISTERED REPORT

DERR1-10.2196/46938
Relationship Between Depression and Falls Among Nursing Home Residents: Protocol for an Integrative Review (Preprint)
Authors: Matos Queirós Alcina , von Gunten Armin , Rosselet Amoussou Joëlle , Martins Maria Manuela , Verloo Henk
Published: March 2023

BACKGROUND

Aging exposes individuals to new health disorders and debilitating chronic diseases, yet most older adults, even in functional decline, do not want to leave their homes. Nevertheless, for many, institutionalization in a nursing home (NH) may become essential to ensure their continued safety and health. Depression is one of the most common psychiatric disorders among older adults, especially among those who are institutionalized. Depressed NH residents face a high risk of future functional decline and falls, decreasing their quality of life. The relationship between depression and falls is complex and bidirectional. Previous reviews have focused on home-dwelling older adults or explored the relationship between antidepressant drugs and falls. To the best of our knowledge, no integrative literature reviews have explored the relationship between depression and falls among NH residents.

OBJECTIVE

Analyze studies on the relationship between depression and falls among NH residents.

METHODS

We will conduct an integrative literature review of published articles in relevant scientific journals on the relationship between depression and depressive symptomatology and falls among NH residents. As usually defined, we will consider NH residents to be people aged 65 years and older who can no longer live safely and independently in their homes. We will also consider older adults on short-term stays in an NH for rehabilitation after hospital discharge. Retrieved articles will be screened for eligibility and analyzed following previously reported steps. The most pertinent bibliographical databases will be examined for qualitative, quantitative, and mixed methods studies, from inception until August 31, 2023, thus ensuring that all relevant literature is included. We will also hand-search the bibliographies of all the relevant articles found and search for unpublished studies in any language. If appropriate, we will consider conducting a meta-analysis of the studies retrieved.

RESULTS

A first round of data collection was completed in March 2023. We retrieved a total of 2276 references. A supplementary literature search to ensure the most up-to-date evidence is ongoing. We anticipate that the review will be completed in late September 2023, and we expect to publish results at the end of December 2023.

CONCLUSIONS

This integrative review will increase knowledge and understanding of the complex relationship between depression and falls in NH environments. Its findings will be important for developing integrated, multidisciplinary models and care recommendations, adaptable to each NH resident’s situation and health status, and for creating preventive interventions to help them maintain or recover optimal health stability.

INTERNATIONAL REGISTERED REPORT

DERR1-10.2196/46995
Cultural and Biological Aspects of Romantic Relationships and Domestic Violence in Intercultural Couples
Authors: Carvalho Husten da Silva , Costa Rosane de Albuquerque
Published: March 2023

During the last 30 years, the globalization process has favored migratory movements. Social networks and websites promoting romantic relationships facilitate women´s marketing from developing to developed countries. To better understand the effects of the patriarchal model and intercultural factors on romantic relationships, we reviewed the recent literature seeking to address the reasons that lead to this type of relationship, and its consequences. For this, we searched for available articles in LILACS, MEDLINE, PubMed, and SciELO databases, and 67 articles met the inclusion criteria. The will to improve living conditions may lead to the decision of migrating. However, the statement about "interest" could not be confirmed. Websites contents reflect the patriarchal model of seeking relationships according to the representation of men´s superiority who act as "women´s consumers. A recent study showed that Spanish men seek a relationship with women from developing countries, mainly because they are in a condition of "crisis of masculinity. Studies have shown that immigrant women are more vulnerable to violence, social exclusion, and risks of mental health disorders. The different patterns of aggression, according to gender, are, yet, inconclusive. Through our study, based on the current literature, it was possible to identify a set of factors that lead to migratory flows in the context of romantic relationships and how intercultural couples have conducted to preserve their subjectivities and mental health.
An economic analysis of organic apple cultivation in the Foothills of Saramati mountain range: A case study of Thanamir village of Kiphire district, Nagaland
Authors: Jamir Chubakumzuk
Published: March 2023

A study was carried out to assess the production and marketing condition of apple (Malus domestica L.) in the Thanamir village of Nagaland. With diverse agro-climatic condition, varied soil and low temperature with wide regional variation, this region is highly suitable for cultivation of apple. This article focuses on the importance of apple fruit, its utilization and the economic profitability from apple crop based farming system. Research survey of farmers producing apple was conducted in 2022. Total of one hundred thirty (132) apple producers were selected using random sampling methods. The result shows BCR was estimated to be 1.95, which was found greater than unity. This showed that the apple farming is quite profitable in Thanamir. The finding shows that Cobb-Douglas production function exhibits increasing return to scale. The study concluded that apple cultivation can be made viable enterprise with increased focus on investment climate by subsidising farm input, providing affordable loans to the farmers for a sustainable production and strengthening rural infrastructure. The study pointed out that the apple cultivation could be a highly beneficial and market-oriented activity in Thanamir.
The International Responsibility of non-State Armed Groups and Victims’ Right to Reparations
Authors: Carvajal Aguilar Carlo
Published: March 2023

It is commonly accepted that quasi-state Non-State Armed Groups may violate international humanitarian law and that, under certain circumstances, their members may commit breaches of international criminal and human rights law. However, given the very nature of such groups —and their controversial role in the international legal system—, their victims’ right to reparations is often questioned. This article outlines the legal questions surrounding serious violations of international law committed by Non-State Armed Groups and argues that their victims are entitled to reparations.
Structural Behaviour of Hybrid Fibres Concrete Using Regression Analysis
Authors: Suman Sanjeev , Tiwari Gourav , Jha Abhay Kumar , Kumar Barun
Published: March 2023

Abstract: The main objective of the current effort is to create hybrid fibre reinforced concrete with improved strength properties, structural behaviour, and structural performance by adding the right dosage amount of hybrid fibre. In this work, it is suggested to employ hybrid fibres of two different types, one of which is Steel fibre, a metallic fibre, and the other is Polyvinyl Alcohol fibre, which has a synthetic foundation. In this way, the concrete gains high tensile strength, flexural strength, and compressive strength due to the inclusion of steel fibre with a high Young's modulus and tensile strength. The steel fibre functions as a crack arrestor, stopping the growth of cracks at the macro level. The microscopic cracks are stopped from spreading by the use of synthetic Polyvinyl Alcohol (PVA) fibre, which is more flexible and ductile, increasing the strength and hardness of the concrete. The objective of the current study is to assess the structural behaviour and strength features of hybrid fibre reinforced concrete. For different mix proportions, such as 0% Steel fibre and 1% PVA fibre, 0.25% Steel fibre and 0.75% PVA fibre, 0.50% Steel fibre and 0.50% PVA fibre, 0.75% Steel fibre and 0.25% PVA fibre, and 1% Steel fibre and 0% PVA fibre by the volume of concrete, the specimens were cast with the addition of hybrid fibres at a total volume fraction of 1%.
Cloud Formation (IaC): Deploying a Containerized Application on Cloud
Authors: More Shubham , Piprewar Uddesh , Lamsoge Vishal , Puramkar Balwesh , Dandhare Gayatri
Published: March 2023

Abstract: This study is a literature review on cloud computing trends as one of the Fastest growing technologies in the computer industry and their benefits and opportunities for all types of organizations.In addition, it addresses the challenges and problems that contribute to increasing the number of customers willing to adopt and use the technology. A mixed research study approach was adopted for the study, that is by collecting and analysing both quantitative and qualitative information within the sane literature review and summarizing the findings of previous (related) studies. Results highlights the current and future trends of cloud computing and exposes readers to the challenges and problems associated with cloud computing. The reviewed literature showed literature showed that the technology is promising and is expected to grow in the future. Researchers have proposed many techniques to address the problems and challenges of cloud computing, such as security and privacy risks, through mobile cloud computing and cloud-computing governance.
Exploring the Effectiveness of Preordering Technologies in the Food Industry to Other Technology Solutions
Authors: Saini Shubham , Chauhan Shubham , Khan Sirajuddin , Pal Shiv-Das , Rani Alpna
Published: March 2023

Abstract: There is frequently a sizable influx of people looking to interact, shop, or eat on college campuses as well as in public locations like food courts and retail malls. But because of the heavy traffic, there are frequently huge queues at the restaurants, which costs customers a lot of time. The current COVID-19 outbreak has also highlighted how crucial it is to minimise intimate contact between people. As a result, using contactless ordering and payment systems has grown in popularity as a way to reduce the spread of disease. Hence, using effective and secure contactless transaction technologies may help to improve customer service while also emphasising public health and safety. To solve the problem of lengthy queues at restaurants in congested public spaces. We will make an application which it let you schedule a certain time for your order to be ready by placing an advance food order while shopping or even from home. Then, simply go to the food outlet and collect your food, ready to enjoy. Our Work can be used in a restaurant and universities cafeteria.
Automated Question Generator using NLP
Authors: Chakankar Tejas , Shinkar Tejas , Waghdhare Shreyash , Waichal Srushti , Phadtare Mrs. M. M.
Published: March 2023

Abstract: The purpose of the Automated Paper Generator is to automatize the winning guide machine with the aid of the help of computerized gadgets and full-fledged laptop code, pleasurable their requirements, simply so their precious facts/data can be maintained for an extended quantity with clean gaining access to and manipulation of the desired software program and hardware are honestly available on the market and easy to discern with. automatic query Paper Generator, as represented above, will result in blunders loss, at ease, reliable, and brief control system. it can help the person to not forget their opportunity sports but rather to concentrate on file preserving. So, it's going to assist an organization in the higher utilization of sources. The enterprise will keep computerized records while not redundant entries. which means that one needn't be distracted by info it is now not applicable while having the ability to acquire the statistics. The goal is to automatize its existing guide gadget by way of the assistance of picked equipment and complete-fledged laptop software, pleasurable their requirements, just so their precious facts/statistics can be preserved for an extended quantity with sincere access to and manipulation of the equal. on the whole, the venture describes the manner to manipulate permanently overall performance and better offerings for the customers. Texts with capacity academic well-worth have ended up on the market through the net. however, the victimization of those new texts in lecture rooms introduces several challenges, one in every of which is that they typically lack compliance with physical activities and assessments. right here, we will be inclined to address part of this task by way of automating the creation of a specific form of assessment object and the use of various questions developing with taxonomies. specially, we concentrate on mechanically generating actual WH queries. Our purpose is to make an automatic gadget if you want to take as enter a text and flip out as output questions for assessing a reader's understanding of the records within the text. The questions would possibly then be supplied to a trainer, who would possibly pick and revise people who she or he judges to be beneficial.
Calculating PI Related Indices and Its Polynomial of Hyaluronic Acid and Conjugates
Authors: Kandan P. , Subramanian S. , Rajesh P.
Published: March 2023

A large number of medical experiments have confirmed that the features of drugs have a close correlation with their molecular structure. Drug properties can be obtained by studying the molecular structure of corresponding drugs. The calculation of the topological index of a chemical graph enables scientists to have a better understanding of the physical chemistry and biological characteristics of drugs. In this paper, we focus on Hyaluronic Acid-Curcumin/Paclitaxel conjugate which are widely used in the manufacture of anticancer drugs. Therefore in this paper we have computed the Padmakar-Ivan related indices and its polynomial of the Hyaluronic Acid-curcumin/paclitaxel conjugate by using edge partitioning technique.
Using Linear Regression For Used Car Price Prediction
Authors: MUTİ Sumeyra , YILDIZ Kazım
Published: March 2023

Abstract: Recently, there have been studies on the use of machine learning algorithms for price prediction in many different areas such as stock market, rent a house and used car sales. Studies give information about which algorithm is more successful in price prediction using different machine learning methods. The most commonly used method for price prediction is the linear regression model. In our study, we examined the effectiveness of the linear regression model for used car price prediction. In our study, we applied the linear regression model on a data set that includes the features and price information of vehicles in Turkey for the year 2020. As a result, when we selected 1/3 of the data set as the test data, we observed that the R2 score for the prediction success of our model was 73%. More successful results can be obtained with different data sets or a more detailed data preprocessing.