Impact of Fractional Flow Reserve Derived From Coronary Computed Tomography Angiography on Heart Team Treatment Decision-Making in Patients With Multivessel Coronary Artery Disease
Authors: Andreini Daniele , Modolo Rodrigo , Katagiri Yuki , Mushtaq Saima , Sonck Jeroen , Collet Carlos , De Martini Stefano , Roberto Maurizio , Tanaka Kaoru , Miyazaki Yosuke , Czapla Jens , Schoors Danny , Plass Andre , Maisano Francesco , Kaufmann Philipp , Orry Xavier , Metzdorf Pierre-Adrien , Folliguet Thierry , Färber Gloria , Diamantis Ioannis , Schönweiß Marc , Bonalumi Giorgia , Guglielmo Marco , Ferrari Cristina , Olivares Paolo , Cavallotti Laura , Leal Ingrid , Lindeboom Wietze , Onuma Yoshinobu , Serruys Patrick W. , Bartorelli Antonio L. ,   for the SYNTAX III REVOLUTION Investigators
Published: December 2019

Background:

Fractional flow reserve (FFR) is a reliable tool for the functional assessment of coronary stenoses. FFR computed tomography (CT) derived (FFR
CT
) has shown to be accurate, but its clinical usefulness in patients with complex coronary artery disease remains to be investigated. The present study sought to determine the impact of FFR
CT
on heart team’s treatment decision-making and selection of vessels for revascularization in patients with 3-vessel coronary artery disease.

Methods:

The trial was an international, multicenter study randomizing 2 heart teams to make a treatment decision between percutaneous coronary interventions and coronary artery bypass grafting using either coronary computed tomography angiography or conventional angiography. The heart teams received the FFR
CT
and had to make a treatment decision and planning integrating the functional component of the stenoses. Each heart team calculated the anatomic SYNTAX score, the noninvasive functional SYNTAX score and subsequently integrated the clinical information to compute the SYNTAX score III providing a treatment recommendation, that is, coronary artery bypass grafting, percutaneous coronary intervention, or equipoise coronary artery bypass grafting-percutaneous coronary intervention. The primary objective was to determine the proportion of patients in whom FFR
CT
changed the treatment decision and planning.

Results:

Overall, 223 patients were included. Coronary computed tomography angiography assessment was feasible in 99% of the patients and FFR
CT
analysis in 88%. FFR
CT
was available for 1030 lesions (mean FFR
CT
value 0.64±13). A treatment recommendation of coronary artery bypass grafting was made in 24% of the patients with coronary computed tomography angiography with FFR
CT
. The addition of FFR
CT
changed the treatment decision in 7% of the patients and modified selection of vessels for revascularization in 12%. With conventional angiography as reference, FFR
CT
assessment resulted in reclassification of 14% of patients from intermediate and high to low SYNTAX score tertile.

Conclusions:

In patients with 3-vessel coronary artery disease, a noninvasive physiology assessment using FFR
CT
changed heart team’s treatment decision-making and procedural planning in one-fifth of the patients.

Clinical Trial Registration:

URL:
https://www.clinicaltrials.gov
. Unique identifier: NCT02813473.