bluuebunny/crossref_metadata_2025 huggingface dataset:
A randomized controlled trial of CAPEOX vs observation in patients with early-stage colorectal cancer with positive MRD after curative surgery (CAREME).
Authors: Ding Ke-Feng , Xiao Qian , Xiang Jianbin , Zhou Yiming , Song Jun , Xu Yixin , Huang Xue-Feng , Chen Min , Du Jinlin , Jin Ketao , Dai Xiaoyu , Shen Zhonglei , Li Taiyuan , Ye Shanping , Cui Wei , Zhao Yibin , Chen Wenbin , Cheng Xiaofei , Ju Haixing , Zhang Qian ,   Genecast Medical Group
Published: January 2024

TPS225

Background: Most patients (pts) with early-stage colorectal cancer (CRC) have a good prognosis, but some still relapse shortly after surgery. Effective methods to assess the risk of recurrence in these pts and guide adjuvant chemotherapy (ACT) decision-making are lacking. Increasing studies have shown that circulating tumor DNA (ctDNA) can detect minimal residual disease (MRD) and identify pts with a high risk of recurrence. ACT could improve survival of MRD-positive pts with stage Ⅱ CRC suggested by recent studies, whether it is appropriate for those with stage Ⅰ or clinically low-risk stage Ⅱ CRC remains unknown. Methods: CAREME is a multicenter randomized controlled clinical trial aimed at investigating the benefit of chemotherapy for MRD-positive pts with early-stage CRC. Pts with resected stage Ⅰ or Ⅱ CRC will be evaluated by oncologists. Those who did not receive neoadjuvant therapy and are deemed suitable for active surveillance (i.e., ACT is not needed) will undergo a postoperative ctDNA test using MinerVa MRD assay (a tumor-informed assay covering 769 cancer-related genes). Pts with mismatch repair-deficient tumors will be excluded and stage Ⅱ pts should have no traditional high-risk features according to clinical practice guidelines. Pts with positive ctDNA (N = 38) will be equally randomized into two groups: treatment group (Arm A) or surveillance group (Arm B). Arm A will receive 8 cycles of CAPEOX therapy while pts in Arm B will not receive any ACT; both groups will undergo ctDNA tests at 6 months after randomization and be followed up every 3 months. The primary endpoint is 18-month recurrence-free survival, and a key secondary endpoint is ctDNA clearance at 6 months after randomization. Tumor samples from the pts will be collected for MRD assay and exploratory research. Accrual started in February 2023. Support: Genecast Biotechnology Company. Clinical trial information: NCT05699746 .
SWOG S2107: Randomized phase II trial of encorafenib and cetuximab with or without nivolumab for patients with previously treated, microsatellite stable, BRAFV600E metastatic and/or unresectable colorectal cancer.
Authors: Morris Van K. , Guthrie Katherine A. , Kopetz Scott , Breakstone Rimini , Karasic Thomas Benjamin , Hu Zishuo Ian , Colby Sarah , Fakih Marwan , Gholami Sepideh , Gold Philip Jordan , Philip Philip A.
Published: January 2024

TPS234

Background: Patients with microsatellite stable (MSS), BRAFV600E metastatic colorectal cancer (mCRC) experience poor survival outcomes. Treatment with the BRAF inhibitor encorafenib (E) and anti-EGFR antibody cetuximab (C) is an approved treatment combination, with a reported overall response rate (ORR) of 20% and median progression-free survival (PFS) of 4.1 months. Anti-PD-1 antibodies like nivolumab (N) are ineffective as monotherapy for patients with MSS, BRAFV600E mCRC. In preclinical models of MSS, BRAFV600E CRC, inhibition of BRAF and EGFR induces a loss of expression of mismatch repairs genes and promotes a microsatellite instability-high phenotype, which may prime these tumors for response to immunotherapy. In support of these findings, a single-institution clinical trial of E + C + N for 26 participants with MSS, BRAFV600E mCRC reported an ORR of 50% and median PFS of 7.2 months. We hypothesize that the addition of N to E + C will improve PFS for participants with MSS, BRAFV600E mCRC. Methods: In this prospective phase II clinical trial (N=75), participants with previously treated MSS, BRAFV600E mCRC will be randomized 2:1 into 2 arms, respectively: experimental treatment (E + C + N) or standard treatment (E + C). No prior BRAF, EGFR, or immunotherapy agents are allowed. All participants will receive E (300 mg PO daily) and C (500 mg/m2 IV every 14 days), and participants in the experimental arm will receive N (480 mg IV every 28 days). The primary endpoint is PFS. Secondary endpoints include overall survival, best overall response, duration of response, and safety/tolerability. Using a one-sided α= .10 and power 80%, we target an improvement in median PFS from 4.2 to 7.3 months and a hazard ratio of 0.57. Additional participants specimens will be collected for exploratory correlative research. As of 9/2023, 37 of 75 planned participants have been enrolled. Clinical trial information: NCT05308446 .
Surgeon fatigue in robot-assisted and laparoscopic gastrectomy for gastric cancer: Exploratory prospective observational study ancillary to JCOG1907 randomized controlled trial (JCOG1907A1).
Authors: Fujiya Keiichi , Terashima Masanori , Kita Ryosuke , Mizusawa Junki , Makuuchi Rie , Omori Takeshi , Yanagimoto Yoshitomo , Isobe Taro , Ojima Toshiyasu , Kawashima Yoshiyuki , Fukuda Haruhiko , Kurokawa Yukinori , Boku Narikazu , Yoshikawa Takaki
Published: January 2024

TPS422

Background: Fatigue is being increasingly recognized as an important factor in surgical procedures, because it leads to errors in surgeons' decisions and reduced operating efficiency. In comparison to laparoscopic surgery, robot-assisted surgery is expected to reduce surgeon fatigue due to ergonomic adjustments, comfortable sitting positions, minimal restriction of instrument movement, and stable visualization. The aim of this study is to assess surgeon fatigue and explore the superiority of robot-assisted gastrectomy over laparoscopic gastrectomy in surgeon fatigue. Methods: This study is conducted as a prospective observational study ancillary to a randomized controlled phase III trial investigating the superiority in safety of robot-assisted gastrectomy over laparoscopic gastrectomy for clinical stage T1-4aN0-3 gastric cancer (JCOG1907: UMIN000039825). The lead surgeon and the first assistant performing surgeries as protocol treatment in JCOG1907 were included. Surgeon fatigue is quantitatively assessed using multiple assessment tools. The primary endpoint is the average NASA-Task Load Index (NASA-TLX) value for the lead surgeons. Secondary endpoints include six individual parameters of NASA-TLX, visual analog scale assessments for fatigue, advanced trail-making tests, and continuous heart rate variability measurements for lead surgeons and first assistants. The primary analysis compares surgeon fatigue between robot-assisted and laparoscopic surgery. Secondary analyses examine the association between surgeon fatigue and various factors, such as surgeon and patient background, and surgical findings, as well as cross-correlations among measures of surgical fatigue. In addition, the association between surgeon fatigue and postoperative complications and its impact on long-term survival outcomes is also evaluated. The sample size is 500 surgical cases, with a planned accrual period of 2 years. This study was initiated in April 2023 and registered at the University Hospital Medical Information Network as UMIN000052120. As of August 2023, 52 cases (10.4% of the planned accrual) have been enrolled in the study. Clinical trial information: UMIN000052120 .
Phase 1b/2, open-label dose-escalation and -expansion study evaluating trastuzumab deruxtecan (T-DXd) monotherapy and combinations in patients (pts) with HER2+ and HER2-low gastric cancer (GC): DESTINY-Gastric03 (DG-03).
Authors: Janjigian Yelena Y. , Raoufmoghaddam Saeed , Sztachelska Magdalena , Winter Megan , Das Satya (Nanu)
Published: January 2024

TPS424

Background: T-DXd is approved for treatment of advanced/metastatic HER2+ GC after a trastuzumab-based regimen. The efficacy of T-DXd in advanced HER2+ (IHC 3+ or IHC 2+/ISH+) GC has been shown (confirmed objective response rate [ORR], 43% vs 12% with standard chemotherapy) in previously treated Japanese or South Korean pts (DG-01) and in Western pts with progression on a trastuzumab-containing regimen (confirmed ORR, 42%; DG-02). Also, antitumor activity was shown in pts with HER2-low GC (confirmed ORR, 26.3% [IHC 2+/ISH−], 9.5% [IHC 1+]) in DG-01. Other studies have shown benefits of immunotherapies combined with trastuzumab and other chemotherapies for treatment of HER2+ GC. The DG-03 trial is evaluating the safety and efficacy of T-DXd in combination with chemotherapy and/or immunotherapy in HER2-expressing GC. Previously, confirmed ORRs of 50% and 43% were reported with T-DXd + 5-fluorouracil (5-FU) and T-DXd + capecitabine (Cap), respectively, in the second-line or later setting in part 1 of DG-03. The protocol was amended to add an additional arm in part 2 and a new part 3, which will investigate T-DXd in combination with a fluoropyrimidine and volrustomig (MEDI5752), a PD-1/CTLA-4 bispecific antibody, in pts with HER2+ and HER2-low (IHC 2+/ISH− or IHC 1+) GC. Methods: DG-03 (NCT04379596)is a multicenter, dose-escalation (part 1) and -expansion (parts 2 and 3) study in HER2-expressing, locally advanced or metastatic, unresectable gastric, gastroesophageal junction, or esophageal adenocarcinoma. In arm F of part 2, pts with previously untreated HER2+ GC will be treated with T-DXd + investigator’s choice of 5-FU or Cap + pembrolizumab. In part 3, pts with previously untreated HER2+ (arm 3A) or HER2-low (arm 3B) GC will receive T-DXd + investigator’s choice of 5-FU or Cap + volrustomig. The primary endpoint in parts 2 and 3 is investigator-assessed confirmed ORR per RECIST v 1.1. Secondary endpoints include safety, duration of response, disease control rate, progression-free survival, overall survival, pharmacokinetics, and immunogenicity. Clinical trial information: NCT04379596 .
Nivolumab Plus Chemotherapy in Epidermal Growth Factor Receptor–Mutated Metastatic Non–Small-Cell Lung Cancer After Disease Progression on Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors: Final Results of CheckMate 722
Authors: Mok Tony , Nakagawa Kazuhiko , Park Keunchil , Ohe Yuichiro , Girard Nicolas , Kim Hye Ryun , Wu Yi-Long , Gainor Justin , Lee Se-Hoon , Chiu Chao-Hua , Kim Sang-We , Yang Cheng-Ta , Wu Chien Liang , Wu Lin , Lin Meng-Chih , Samol Jens , Ichikado Kazuya , Wang Mengzhao , Zhang Xiaoqing , Sylvester Judi , Li Sunney , Forslund Ann , Yang James Chih-Hsin
Published: January 2024

PURPOSE

The phase III CheckMate 722 trial (ClinicalTrials.gov identifier: NCT02864251 ) evaluated nivolumab plus chemotherapy versus chemotherapy in patients with epidermal growth factor receptor ( EGFR)–mutated metastatic non–small-cell lung cancer (NSCLC) after disease progression on EGFR tyrosine kinase inhibitors (TKIs).

METHODS

Patients with disease progression after first- or second-generation EGFR TKI therapy (without EGFR T790M mutation) or osimertinib (with/without T790M mutation) were randomly assigned 1:1 to nivolumab (360 mg once every 3 weeks) plus platinum-doublet chemotherapy (once every 3 weeks) or platinum-doublet chemotherapy alone (once every 3 weeks) for four cycles. Primary end point was progression-free survival (PFS). Secondary end points included 9- and 12-month PFS rates, overall survival (OS), objective response rate (ORR), and duration of response (DOR).

RESULTS

Overall, 294 patients were randomly assigned. At final analysis (median follow-up, 38.1 months), PFS was not significantly improved with nivolumab plus chemotherapy versus chemotherapy (median, 5.6 v 5.4 months; hazard ratio [HR], 0.75 [95% CI, 0.56 to 1.00]; P = .0528), with 9- and 12-month PFS rates of 25.9% versus 19.8%, and 21.2% versus 15.9%, respectively. Post hoc PFS subgroup analyses showed a trend favoring nivolumab plus chemotherapy in patients with tumors harboring sensitizing EGFR mutations (HR, 0.72 [95% CI, 0.54 to 0.97]), one line of previous EGFR TKI (0.72 [95% CI, 0.54 to 0.97]), or both (0.64 [95% CI, 0.47 to 0.88]). Median OS was 19.4 months with nivolumab plus chemotherapy versus 15.9 months with chemotherapy, while ORR was 31.3% versus 26.7%, and median DOR was 6.7 versus 5.6 months, respectively. Grade 3/4 treatment-related adverse events occurred in 44.7% and 29.4% of patients treated with nivolumab plus chemotherapy and chemotherapy alone, respectively.

CONCLUSION

Nivolumab plus chemotherapy did not significantly improve PFS versus chemotherapy in patients with EGFR-mutated metastatic NSCLC previously treated with EGFR TKIs. No new safety signals were identified.
A Wall Is Just a Wall
Authors: Hillyer Reiko
Published: January 2024

Throughout the twentieth century, even the harshest prison systems in the United States were rather porous. Incarcerated people were regularly released from prison for Christmas holidays; the wives of incarcerated men could visit for seventy-two hours relatively unsupervised; and governors routinely commuted the sentences of people convicted of murder. By the 1990s, these practices had become rarer as politicians and the media—in contrast to corrections officials—described the public as potential victims who required constant protection against the threat of violence. In A Wall Is Just a Wall Reiko Hillyer focuses on gubernatorial clemency, furlough, and conjugal visits to examine the origins and decline of practices that allowed incarcerated people to transcend prison boundaries. Illuminating prisoners’ lived experiences as they suffered, critiqued, survived, and resisted changing penal practices, she shows that the current impermeability of the prison is a recent, uneven, and contested phenomenon. By tracking the “thickening” of prison walls, Hillyer historicizes changing ideas of risk, the growing bipartisan acceptance of permanent exile and fixing the convicted at the moment of their crime as a form of punishment, and prisoners’ efforts to resist.
Intrigue like Fireworks (奸情如焰火)
Authors: Martin Fran
Published: January 2024

This queer take on the coming-of-age story is sweetly nostalgic and slyly playful. Recalling the narrator’s early teen years under high socialism, it paints a vivid picture of the experiences of a ragtag crew of neighborhood boys in the throes of sexual awakening. The boys’ camaraderie, adventurousness, and position on the margins of mainstream adult society suggests a lighthearted twist on elements of the popular knights-errant genre. At the same time, in its use of invented city names based on geometric shapes, the story conjures a somewhat surreal atmosphere and a quasi-sci-fi sensibility. Ultimately, this artfully reflexive fairytale challenges any complacent assumptions about the universal straightness of everyday life under socialism.
Some Admire Wisdom, Others Do Not (有人赞美聪慧， 有人则不)
Authors: Hird Derek
Published: January 2024

Through the narrator’s reflections on his childhood, desire, love, and rejection are poignantly explored in same-sex and heterosexual dynamics. His contemplations of the deaths he encountered as a child add a level of spiritual meditation. Like Spinoza’s free man, the narrator aspires to think about life, but is stuck with memories of deaths of friends and family members: suicides by hanging, shooting, drowning, a stillborn child, a child who dies from illness. For the narrator, life is more frightening than death. Holding on to the Christian beliefs that his grandparents turned to amid the chaos of China’s twentieth century, the narrator counts himself among those who admire death as an aspect of God’s sublime wisdom. By sharing his memories of death and desire under a regime where these topics are not always speakable, he hopes to move a little closer to freedom.
Orphans of the Japanese Empire (日本遗民)
Authors: Engebretsen Elisabeth Lund
Published: January 2024

This retrospective coming-of-age narrative is set against the tense backdrop of the longue durée Sino-Japanese war and its manifold of consequences. The protagonist weaves diverse tales of school experience in the Chinese socialist education system, the intricacies of gender, parental and neighborhood relationships, and intimate desires (and disgust). As such, this story depicts tender yet conflicted affects of emergent queer masculinity and desire, set in the midst of broader challenges such as neighborhood domestic violence, anti-imperial sensitivities and ultimately, intimate longing and loss.
The Silent Advent of the Age of Sexual Persuasion (言性时代悄然莅临)
Authors: Liu Petrus
Published: January 2024

Centered on a young boy who has been teased and bullied for years because he cries a lot, this coming-of-age story explores issues of effeminophobia, sexual possession, passion, and openness. For the story’s protagonist, being penetrated by his sexual partner is a form of erotic submission and in fact a survival strategy, and he urges all bottoms to let go of the values of the old age of romantic persuasion, such as modesty, subtlety, and artifice and replace them with exuberant appreciation of their partners’ sexual organs. Although the age of sexual persuasion is marked by verbal excess and openness, it comes silently. By characterizing this mental shift as the inauguration of a new era, the narrator describes sexuality with a revolutionary vocabulary that is typically reserved for socialism.
Men Men Men Women Women Women (男男男女女女)
Authors: Guo Yizhou
Published: January 2024

This story presents three queer vignettes of urban life in postsocialist China. A young man drifts from one host household to another and sets up homoerotic desires in both places; a woman leaves her husband for another woman; a happy homosexual couple breaks apart because of an unsolicited affair. In these stories, the coming and going of queer sexualities are inconspicuous, nonchalant, and even detached. The imagery of the public toilet, an oft-used queer symbol in Cui’s writing, surfaces here again to provide a duly queer parody of the solemn.
Fire and Wolf Share a Fondness for Male Beauty (老火和老狼同好男色)
Authors: Guo Yizhou
Published: January 2024

In this queer take on erotica fiction, the love triangle among Fire, Wolf, and their shared object of desire, Qi Shishi, spans decades and is nothing short of spectacular, comical, and absurd. The story contains all the elements that romantic erotica should have, but in a departure from the conventional heterosexual motif, homoeroticism takes center stage, taking readers on a rollercoaster ride through the two young men’s adolescence. In Cui’s writing, queer sexuality is portrayed as part of the mundane way of life, of the everyday human experience.
Platinum Bible of the Public Toilet (公厕白金宝典)
Authors: Kang Wenqing , Clayton Cathryn H.
Published: January 2024

This novella is concerned with a group of young men associated with the International Red Star Broadcasting Station—Cui Zi’en’s parody of the Chinese Communist Party’s propaganda machine—who make it their mission to create a society called “Public Toilet Utopia.” They report on stories about public toilets throughout the city, from mechanical malfunctions to emergency weddings. They invite anthropologists, literary critics, and student leaders to debate on the relative merits of private versus public bathrooms. While some advocate for the complete abolition of private and public bathrooms alike so that human beings can release their bodily fluids without physical barriers, others argue for the socialization and expansion of public bathrooms so that other species can enjoy their benefits. In making the question of public bathrooms central for socialism and collective mobilization, the story’s main characters also arrive at a renewed understanding of the social construction of gender.
Interview with Cui Zi'en
Authors: Liu Petrus , Rofel Lisa
Published: January 2024

The volume’s coeditors conducted an interview with the author, Cui Zi'en. They discussed the genesis of the book’s stories; Cui’s family background and literary influences; Cui’s career as a writer, filmmaker, educator, and activist; the meanings of the book’s title and symbols; and the cultural politics of translation. Cui spoke on the complexities of what it means to be “queer” in China during the socialist period and today and what he wishes to communicate to English-language readers as his literary work is being introduced to the Western world for the first time.
Training Performance Assessment for Intracranial Aneurysm Clipping Surgery Using a Patient-Specific Mixed-Reality Simulator: A Learning Curve Study
Authors: Cuba Miguel , Vanluchene Hanne , Murek Michael , Goldberg Johannes , Müller Mandy D. , Montalbetti Matteo , Janosovits Katharina , Rhomberg Thomas , Zhang David , Raabe Andreas , Joseph Fredrick J. , Bervini David
Published: January 2024

BACKGROUND AND OBJECTIVES:

The value of simulation-based training in medicine and surgery has been widely demonstrated. This study investigates the introduction and use of a new mixed-reality neurosurgical simulator in aneurysm clipping surgery, focusing on the learning curve and performance improvement.

METHODS:

Five true-scale craniotomy head models replicating patient-specific neuroanatomy, along with a mixed-reality simulator, a neurosurgical microscope, and a set of microsurgical instruments and clips, were used in the operation theater to simulate aneurysm microsurgery. Six neurosurgical residents participated in five video-recorded simulation sessions over 4 months. Complementary learning modalities were implemented between sessions. Thereafter, three blinded analysts reported on residents' use of the microscope, quality of manipulation, aneurysm occlusion, clipping techniques, and aneurysm rupture. Data were also captured regarding training time and clipping attempts.

RESULTS:

Over the course of training, clipping time and number of clipping attempts decreased significantly (P = .018, P = .032) and the microscopic skills improved (P = .027). Quality of manipulation and aneurysm occlusion scoring improved initially although the trend was interrupted because the spacing between sessions increased. Significant differences in clipping time and attempts were observed between the most and least challenging patient models (P = .005, P = .0125). The least challenging models presented higher rates of occlusion based on indocyanine green angiography evaluation from the simulator.

CONCLUSION:

The intracranial aneurysm clipping learning curve can be improved by implementing a new mixed-reality simulator in dedicated training programs. The simulator and the models enable comprehensive training under the guidance of a mentor.
Cell division angle predicts the level of tissue mechanics that tune the amount of cerebellar folding
Authors: Cook Amber G. , Bishop Taylor V. , Crowe Hannah R. , Stevens Daniel N. , Reine Lauren , Joyner Alexandra L. , Lawton Andrew K.
Published: January 2024

Modeling has led to proposals that the amount of neural tissue folding is set by the level of differential expansion between tissue layers and that the wavelength is set by the thickness of the outer layer. Here, we used inbred mouse strains with distinct amounts of cerebellar folding to investigate these predictions. We identified a distinct critical period during which the folding amount diverges between the two strains. In this period, regional changes in the level of differential expansion between the external granule layer (EGL) and underlying core correlate with the folding amount in each strain. Additionally, the thickness of the EGL varies regionally during the critical period alongside corresponding changes in wavelength. The number of SHH-expressing Purkinje cells predicts the folding amount, but the proliferation rate in the EGL is the same between the strains. However, regional changes in the cell division angle within the EGL predicts both the tangential expansion and the thickness of the EGL. Cell division angle is likely a tunable mechanism whereby both the level of differential expansion along the perimeter and the thickness of the EGL are regionally tuned to set the amount and wavelength of folding.
Responses of the Serum Lipid Profile to Exercise and Diet Interventions in Nonalcoholic Fatty Liver Disease
Authors: Qi Zhen , Le Shenglong , Cheng Runtan , Du Xiaming , Zhao Can , Zhang Zhengyun , Zhang Xiaobo , Feng Lei , Schumann Moritz , Mao Lijuan , Cheng Sulin
Published: January 2024

Background

This study aimed to assess the response patterns of circulating lipids to exercise and diet interventions in nonalcoholic fatty liver disease (NAFLD).

Methods

The 8.6-month four-arm randomized controlled study comprised 115 NAFLD patients with prediabetes who were assigned to aerobic exercise (AEx, n = 29), low-carbohydrate diet (Diet, n = 28), aerobic exercise plus low-carbohydrate diet (AED, n = 29) and non-intervention (NI, n = 29) groups. Hepatic fat content (HFC) was quantified by proton magnetic resonance spectroscopy. Serum lipidomic analytes were measured using liquid-chromatography mass spectrometry.

Results

After intervention, the total level of phosphatidylcholine (PC) increased significantly in the AEx group (p = 0.043), while phosphatidylethanolamine (PE) and triacylglycerol decreased significantly in the AED group (p = 0.046, p = 0.036 respectively), phosphatidylserine decreased in the NI group (p = 0.002). Changes of 21 lipid metabolites were significantly associated with changes of HFC, among which half belonged to PC. Most of the molecules related to insulin sensitivity belonged to sphingomyelin (40 of 79). Controlling for the change of visceral fat, the significant associations between lipid metabolites and HFC remained. In addition, baseline serum lipids could predict the response of HFC to exercise and/or diet interventions (PE15:0/18:0 for AED, AUC = 0.97; PE22:6(4Z,7Z,10Z,13Z,16Z,19Z)/0:0 for AEx, AUC = 0.90; and PC14:1(9Z)/19:1(9Z) for Diet, AUC = 0.92).

Conclusions

Changes of lipidome after exercise and/or diet interventions were associated with HFC reductions, which are independent of visceral fat reduction, particularly in metabolites belonging to phosphatidylcholine. Importantly, baseline phosphatidylethanolamine could predict the HFC response to exercise and phosphatidylcholine predicted the response to diet. These results indicate that a circulating metabolomics panel can be used to facilitate clinical implementation of lifestyle interventions for NAFLD management.
Ultrastructure of mice testes affected by orally administered crocin of crocus sativus
Authors: Al-Fartwsy ARH , Mohammadpour AA , Parham A
Published: January 2024

In this study, thirty-two adult male mice were divided into four groups control and experimental treatment groups received crocin at 4, 20, and 100 mg/kg daily for six weeks. In results, testosterone level was increased significantly from 18.5 ng/dl in the control to 49.3 ng/dl in group received crocin at 20 mg/kg. The regular features of seminiferous tubules with increased Sertoli cells have been observed in the 20mg/kg crocin group.

 In the group received crocin at 100 mg/kg, many of the seminiferous tubules were atrophic, spermatogenic cells were discontinuous in the same areas while the space among them has been increased, and fewer interstitial tissue between seminiferous tubules were observed. The changes were markedly advanced by increasing the number of atrophied seminiferous tubules.

Electron microscopic results showed the large mitochondria with normal crista and dilated rough endoplasmic reticulum in spermatid cells of the 20 mg/kg crocin group.

In the 100 mg/kg crocin group, most of the cell cytoplasm showed vacuolated mitochondria with patchy matrix and distorted vision cristae, with many lysosomes, lipid droplets and vacuoles. Some sperms had abnormal swollen nuclear and irregular wavy acrosomal system.

The results of the present study showed that crocin at 20 mg/kg has a protective effect on the germinal epithelium of seminiferous tubules while at 100 mg/kg had destructive effects on the histological structure of the treated mice testicles.

In conclusion, treating healthy male mice with crocin for six weeks increased the testosterone concentration while at 100 mg/kg damaged the testicle’s structure
Παράγοντες που διευκολύνουν τη σχεδιάση στα παιδιά: Το παράδειγμα της μερικής απόκρυψης αντικειμένου.
Authors: Μπονώτη Φωτεινή
Published: January 2024

Η ΠΕΡΙΛΗΨΗ ΒΡΙΣΚΕΤΑΙ ΜΕΣΑ ΣΤΟ ΑΡΧΕΙΟ PDF
The pluralistic nature of the field of psychotherapy: A response to Al Mahrer
Authors: Iwakabe Shigeru
Published: January 2024

ABSTRACT IS AVAILABLE IN THE PDF
Attributing human properties to computer artifacts: Developmental changes in children's understanding of the animate-inanimate distinction
Authors: A. Mikropoulos Tassos , Misailidi Ploussia , Bonoti Fotini
Published: January 2024

ABSTRACT IS AVAILABLE IN THE PDF
Types of fears reported by immigrant Pontian Greeks from the former Soviet Union and by native Greeks
Authors: Papadopoulou Eleni , J. Pickersgill Mary
Published: January 2024

ABSTRACT IS AVAILABLE IN THE PDF
Adolescents' self-concept consistency and the transition from inconsistency to consistency
Authors: Adamson Lena
Published: January 2024

ABSTRACT IS AVAILABLE IN THE PDF
Preface
Authors: Besevegis Elias , Pavlopoulos Vassilis , Georgouleas Georgios
Published: January 2024

ABSTRACT IS NOT AVAILABLE
Μεταψυχολογικό δοκίμιο για τη βία
Authors: Αλεξανδρίδης Αθανάσιος
Published: January 2024

Η ΠΕΡΙΛΗΨΗ ΒΡΙΣΚΕΤΑΙ ΜΕΣΑ ΣΤΟ ΑΡΧΕΙΟ PDF
Εμπειρίες παραμέλησης/ κακοποίησης σε οικογένειες με γονική ψυχική διαταραχή
Authors: Μπίμπου-Νάκου Ιωάννα , Στογιαννίδου Αριάδνη
Published: January 2024

Η ΠΕΡΙΛΗΨΗ ΒΡΙΣΚΕΤΑΙ ΜΕΣΑ ΣΤΟ ΑΡΧΕΙΟ PDF
Προσαρμογή και ψυχομετρικά χαρακτηριστικά του Ερωτηματολογίου Προσωπικότητας για Νέους της Eysenk (JEPI) στην Ελλάδα
Authors: Σ. Αλεξόπουλος Δημήτριος
Published: January 2024

Η ΠΕΡΙΛΗΨΗ ΒΡΙΣΚΕΤΑΙ ΜΕΣΑ ΣΤΟ ΑΡΧΕΙΟ PDF
Ποιτική ανάλυση αναγνωριστικών "λαθών": Ταξινόμηση και κριτική θεώρηση ερευνητικών δεδομένων
Authors: Φιλιππάτου Διαμάντω
Published: January 2024

Η ΠΕΡΙΛΗΨΗ ΒΡΙΣΚΕΤΑΙ ΜΕΣΑ ΣΤΟ ΑΡΧΕΙΟ PDF
Σύγχρονες τάσεις της γνωστικής-συμπεριφορικής ψυχοθεραπείας στη μετανεωτεριστική εποχή
Authors: Χαρίτου - Φατούρου Μίκα
Published: January 2024

Η ΠΕΡΙΛΗΨΗ ΒΡΙΣΚΕΤΑΙ ΜΕΣΑ ΣΤΟ ΑΡΧΕΙΟ PDF
Personality assessmet: Implications of a social-cognitive theory of personality
Authors: Cervone Daniel , Jencius Simon , G. Shadel William
Published: January 2024

ABSTRACT IS AVAILABLE IN THE PDF
Feelings and judgments as subjective evaluations of cognitive processing: How reliable are they?
Authors: Efklides Anastasia
Published: January 2024

ABSTRACT IS AVAILABLE IN THE PDF
Ο ρόλος της βιολογικής ετοιμότητας και του κοινωνικού περιβάλλοντος στην εγκατάσταση κοινωνικής φοβίας
Authors: Ζαφειροπούλου Μαρία , Παππά Ευαγγελία
Published: January 2024

Η ΠΕΡΙΛΗΨΗ ΒΡΙΣΚΕΤΑΙ ΜΕΣΑ ΣΤΟ ΑΡΧΕΙΟ PDF
A multidimensional psysical self-consept: A construct validity approch to theory, measurement and research
Authors: W. Marsh Herbert
Published: January 2024

ABSTRACT IS AVAILABLE IN THE PDF
Το νευροφυσιολογικό υπόβαθρο του άγχους: Ο ρόλος του GABAεργικού συστήματος
Authors: Κ. Μαζαράκης Νεκτάριος , Ν. Νέστορος Ιωάννης
Published: January 2024

Η ΠΕΡΙΛΗΨΗ ΒΡΙΣΚΕΤΑΙ ΜΕΣΑ ΣΤΟ ΑΡΧΕΙΟ PDF
The effectiveness of kindergarten programs wich aim at preventing reading and spelling problems in school: A comparison of three different approaches
Authors: Roth Ellen , Schneider Wolfgang
Published: January 2024

ABSTRACT IS AVAILABLE IN THE PDF
Learning to read in English
Authors: H. K. Seymour Philip , G. Duncan Lynne
Published: January 2024

ABSTRACT IS AVAILABLE IN THE PDF
Communication and satisfaction with the consultation in general practice: A prospective examination
Authors: Iconomou Gregoris , R. Rutter Derek
Published: January 2024

ABSTRACT IS AVAILABLE IN THE PDF
Παιδαγωγική του Διαλόγου: Όψεις ενός επιστημονικού και πολιτικού λάθους
Authors: Κουγιουμουτζάκης Γιάννης
Published: January 2024

Η ΠΕΡΙΛΗΨΗ ΒΡΙΣΚΕΤΑΙ ΜΕΣΑ ΣΤΟ ΑΡΧΕΙΟ PDF
Απώλειες πληροφοριών στη συνέντευξη: Το παράδειγμα της έρευνας αναγκών σε πληθυσμό Ελληνοποντίων
Authors: Δικαίου Μαρία
Published: January 2024

Η ΠΕΡΙΛΗΨΗ ΒΡΙΣΚΕΤΑΙ ΜΕΣΑ ΣΤΟ ΑΡΧΕΙΟ PDF
The contributions of behavioral psychology to the theory and practice of school psychology
Authors: N. Paraskevopoulos Ioannis , D. Giannitsas Nikolaos
Published: January 2024

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Το σύνδρομο επαγγελματικής εξουθένωσης στους εκπαιδευτικούς και στους εργαζόμενους σε επαγγέλματα υγείας και πρόνοιας
Authors: Κάντας Αριστοτέλης
Published: January 2024

Η ΠΕΡΙΛΗΨΗ ΒΡΙΣΚΕΤΑΙ ΜΕΣΑ ΣΤΟ ΑΡΧΕΙΟ PDF
The nature of motives for human consciousness
Authors: Trevarthen Colwyn
Published: January 2024

ABSTRACT IS AVAILABLE IN THE PDF
Μια μελέτη για τη δομή και την ανάπτυξη της εργαζόμενης μνήμης σε σχέση με το συμβολικό σύστημα και τη συνθετότητα των πληροφοριών
Authors: Πλατσίδου Μαρία , Δημητρίου Ανδρέας
Published: January 2024

Η ΠΕΡΙΛΗΨΗ ΒΡΙΣΚΕΤΑΙ ΜΕΣΑ ΣΤΟ ΑΡΧΕΙΟ PDF
Relations between self-consept and social support appraisals duting adolescene: A longitudinal study
Authors: Antunes Christina , Fortaine Anne Maria
Published: January 2024

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Self-concept in specific academic domain values and goals: A study of Comprehensive Multisectoral Lyceum students in Greece
Authors: Koumi Ioanna
Published: January 2024

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Self-esteem, social identity and school achievement in adolescence
Authors: Alves Martins Margarita , Peixoto Francisco
Published: January 2024

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Ο εθισμός υπό το πρίσμα της Βιοψυχολογίας και της Ψυχοφαρμακολογίας: Νευρωνικοί μηχανισμοί και η σημασία τους στη θεραπεία
Authors: Θ. Παναγής Γεώργιος , Α. Καστελλάκης Ανδρέας
Published: January 2024

Η ΠΕΡΙΛΗΨΗ ΒΡΙΣΚΕΤΑΙ ΜΕΣΑ ΣΤΟ ΑΡΧΕΙΟ PDF
Self-concept reflected in students' activities during physics instrution: The role of interest-oriented actions
Authors: Schick Annette
Published: January 2024

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Αρνητική κοινωνική ταυτότητα και κοινωνικο-δομικές συνθήκες: Η επίδραση τους σε ταύτιση και σε αισθήματα δυσαρέσκειας
Authors: Αμπακουμκιν Γιώργος , Γ. Φαρμάκη Χριστίνα , Χατζή Αλεξάνδρα
Published: January 2024

Η ΠΕΡΙΛΗΨΗ ΒΡΙΣΚΕΤΑΙ ΜΕΣΑ ΣΤΟ ΑΡΧΕΙΟ PDF
Truth and the Unity of Logical Validity
Authors: Strollo Andrea
Published: January 2024

According to a traditional view, logical validity consists in necessary truth preservation. Such an account has been argued to carry an apparent commitment to a unique property of truth to be preserved from premises to conclusion. Recent discussions, however, have concluded that if the metaphor of truth preservation is carefully unpacked, no need for a unique property is there. All is needed is that certain structural relations among instantiations of truth properties hold. Against this view, we argue that a unique general truth property is indeed required by logical validity. We first show that the unpacking should be correctly understood since it imposes constraints on the concept and the properties of truth. We then demonstrate that, under such constraints, a general property is not imposed by truth preservation but by another feature of validity: its uniformity. Finally, some options that could be attempted to resist this result are discussed, showing that (strong) truth pluralism and deflationism are affected in different ways.
A Resource-Based View on Individual Absorption in the Context of Multiple Team Memberships
Authors: Backmann Julia , Wimmer Julia , Mortensen Mark , Hartmann Silja , Hoegl Martin , Peus Claudia
Published: January 2024

Knowledge work—frequently characterized as nonroutine and complex—requires individuals to be deeply engrossed with or “absorbed” in their work. Notwithstanding, organizations tend to put knowledge workers in multiple teams, undermining their ability to achieve the level of absorption required to realize their full potential. We examine how knowledge workers who are operating in multiple team contexts navigate competing demands on their time on a daily basis. Based on conservation of resources theory, we posit that the time devoted to the focal team—that is, the primary team in which knowledge workers are most actively involved—fosters absorption. However, this positive relationship is moderated by the number of different team contexts and problem-solving demands that knowledge workers experience daily, as together, these contextual conditions block optimal resource utilization. To test our hypotheses, we apply hierarchical linear modelling to experience-sampling data from 140 knowledge workers surveyed over 10 consecutive working days. Our findings support the hypothesized model, suggesting that daily involvement in multiple team contexts hinders full absorption, especially if daily problem-solving demands are high. Our insights emphasize the importance of the role and potential cost of multiple team membership (MTM) for understanding knowledge workers’ optimal functioning.
Gastrointestinal complications of mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS) syndrome managed by parenteral nutrition
Authors: Horná Simona , Péč Martin Jozef , Krivuš Juraj , Michalová Renáta , Sivák Štefan , Galajda Peter , Mokáň Marián
Published: January 2024

MELAS – an acronym for mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes – is a multiorgan disease caused by a mutation in mitochondrial DNA (mtDNA). Its clinical manifestations are highly variable; mainly stroke-like episodes, seizures, recurrent headaches, or muscle weakness. However, gastrointestinal complications such as chronic intestinal pseudo-obstruction (IPO), pancreatitis, gastroparesis and hepatopathy are also common. In this report we describe a young patient with gastrointestinal complication of MELAS which led to superior mesenteric artery syndrome (SMAS). It is rare but not surprising combination and should be considered in cases with significant weight loss and resistance to symptomatic treatment. The optimal energy support is the main pillar of the treatment.
Isolation of Biofilm Removing Bacteriophages from the Hot Spring of Mae Chan Fault, Chiang Rai, Northern Thailand
Authors:   Faculty of Education, Chiang Rai Rajabhat University, Chiang Rai, 57100, Thailand, Kamtaeja Somboon , Niyom Srinuan ,   Microbial Products and Innovation Research Group, Mae Fah Luang University, Chiang Rai, 57100, Thailand,   Pabongtaoganjan School, Chiang Rai, 57180, Thailand, Jaruseranee Nanthanit ,   Microbial Products and Innovation Research Group, Mae Fah Luang University, Chiang Rai, 57100, Thailand,   School of Science, Mae Fah Luang University, Chiang Rai, 57100, Thailand
Published: January 2024

T errestrial hot springs offer unique habitats for various bacteriophages, revealing potential reservoirs and a library for antibiotic-resistant and biofilm-removing bacteriophages. This study aimed to identify biofilm-removing bacteriophages as a potential method to eradicate antibiotic-resistant bacteria. Samples were collected from the Mae Chan Fault geothermal sites in Chiang Rai province, north of Thailand. Our bacteriophages, HSPT1 and HSPT2, effectively infect Pseudomonas aeruginosa TISTR1287, as measured by their plaque sizes (3.23 ± 0.26 mm) and (1.14 ± 0.18 mm), respectively. Thermostability analysis reveals that the optimal temperature for bacteriophage HSPT1 is between 20 and 60 oC, while for bacteriophage HSPT2, it is between 20 and 40 oC. Biofilm biomass was significantly reduced by the bacteriophages HSPT1 and HSPT2 treatments (1.42 ± 0.81 and 2.51 ± 0.71, respectively). The study reveals that hot spring bacteriophages effectively remove bacterial biofilms, proving their potential as a new treatment option for antibiotic-resistant bacteria in clinical and tourism settings. These bacteriophages, derived from hot springs, have effectively reduced biofilm-forming microorganisms and multidrug-resistant pathogenic bacteria.
Water-based Synthesis of MIL-53(Al) at Room Temperature: An Eff ective Adsorbent for Oxytetracycline (OTC) Antibiotic Removal from Water
Authors:   Faculty of Science, Energy and Environment, King Mongkut’s University of Technology North Bangkok (Rayong Campus), Rayong 21120, Thailand, Hongsawat Parnuch , Kalnaowakul Phuri ,   Aircraft Maintenance Engineering, Department of Mechanical and Industrial Engineering, Rajamangala University of Technology Krungthep, Bangkok 10120, Thailand, Prarat Panida ,   Faculty of Science, Energy and Environment, King Mongkut’s University of Technology North Bangkok (Rayong Campus), Rayong 21120, Thailand
Published: January 2024

MIL-53(Al), a fl exible metal-organic framework, was synthesized by a facile method through a water-based method at room temperature, aligning with the principles of green chemistry. The objective was to investigate its effectiveness in removing pharmaceuticals and personal care products (PPCPs), specifi cally focusing on oxytetracycline (OTC). Our fi ndings revealed that MIL-53(Al) possesses a structure with both micropores and mesopores, with a specifi c surface area of 916 m2/g. MIL-53(Al) notably exhibited a higher OTC adsorption capacity than commercially available powder activated carbon (PAC). The adsorption kinetics followed a pseudo-second-order model, while the Langmuir model accurately described the experimental isotherms for OTC adsorption. MIL-53(Al) outperformed previously reported MOF-based adsorbents with a maximum of 1005 mg/g capacity at pH 7. The fl exible structure induces a breathing effect that signifi cantly improves intraparticle diffusion for OTC, contributing to its adsorption effi ciency. The adsorption of OTC was infl uenced by the solution pH, the acid dissociation constants of OTC, and the charged surface of the adsorbent. Pore fi lling, hydrogen bonding, π-π interaction, electrostatic interaction, and hydrophobic interaction were all associated with the adsorptive interaction between OTC and MIL-53(Al). The MIL-53(Al) also demonstrated good regeneration and reuse, with just a little decreased adsorption capacity after three reuse cycles. These fi ndings indicate that green material MIL-53(Al) has the potential to be an effective adsorbent for removing OTC from water matrices
Comparative Structural Analysis of The Homeodomain Protein in the Bipolar Basidiomycete, Mycoleptodonoides aitchisonii (Bunaharitake)
Authors:   The United Graduate School of Agricultural Sciences, Tottori University, 4-101 Koyama-cho Minami, Tottori 680-8553, Japan, Zhang Weitong , Riffiani Rini ,   Research Center for Applied Microbiology, National Research and Innovation Agency (BRIN) Cibinong Bogor Jawa Barat 16911, Indonesia, Sotome Kozue ,   Faculty of Agriculture, Tottori University, 4-101 Koyama-cho Minami, Tottori 680-8553, Japan, Wada Takayuki ,   Laboratory, Biological Business Department, Ichimasa Kamaboko Co., Ltd., 77-1 Junishin, Agano-shi, Niigata 959-1936, Japan, Shimomura Norihiro ,   Faculty of Agriculture, Tottori University, 4-101 Koyama-cho Minami, Tottori 680-8553, Japan, Boonlue Sophon ,   Department of Microbiology, Faculty of Science, Khon Kaen University, Khon Kaen, 40002, Thailand, Aimi Tadanori ,   Faculty of Agriculture, Tottori University, 4-101 Koyama-cho Minami, Tottori 680-8553, Japan
Published: January 2024

Mycoleptodonoides aitchisonii is a bipolar mushroom with monokaryons can form clamp cells, regardless of the mating type. Previously, only HD2-18 was identifi ed and characterized at the A locus of Maspi18 (A1). In this study, unlike the A locus in strain Maspi18, HD1-7-like gene (Mahd1-7) and HD2-7 gene (Mahd2-7) were identifi ed at the A locus of the compatible strain Maspi7 (A2), but the nine fl anking genes were highly conserved, suggesting that recombination events may have occurred between HD1 and HD2 genes over evolutionary time. Following phylogenetic and HD protein structural comparisons with other basidiomycetes, homeodomains were identifi ed in HD2-7 and HD2-18, but the former lacked nuclear localization signals (NLS) whereas the latter, like the HD1-7-like protein, did not. These fi ndings indicated that one homeodomain and several NLS on the same or different HD proteins is the minimum suffi cient for driving clamp cell formation in M. aitchisonii. The fi ndings implied that over evolutionary time, unlike HD2, the homeodomain in HD1 does not play a major role in clamp cell formation, and that HD1-7 performs the function of carrying the NLS. Herein, we propose a new hypothesis for clamp cell formation in M. aitchisonii. The fi ndings of this study provide a foundation for understanding the role of heterokaryonization in basidiomycete mushrooms.
Benthic Algal Assemblages Associated with Damselfi sh Territories in The Gulf of Thailand
Authors:   Division of Biological Science, Faculty of Science, Prince of Songkla University, Songkhla, Thailand, Titioatchasai Jatdilok ,   Molecular Evolution and Computational Biology Research Unit, Faculty of Science, Prince of Songkla University, Songkhla, Thailand, Kim Jeong Ha ,   Department of Biological Sciences, Sungkyunkwan University, Suwon, S. Korea, Mayakun Jaruwan ,   Division of Biological Science, Faculty of Science, Prince of Songkla University, Songkhla, Thailand,   Molecular Evolution and Computational Biology Research Unit, Faculty of Science, Prince of Songkla University, Songkhla, Thailand
Published: January 2024

Territorial damselfi sh are herbivorous fi sh that help maintain algal diversity and abundance by aggressive territorial defense and algal farming. We investigated the effect of territorial damselfi sh on algal diversity and abundance on a reef at Ko Taen, Surat Thani Province, Thailand. Ten permanent patches (20 × 20 cm2) were set up inside and ten outside damselfi sh territory and monitored bimonthly. We found 22 macroalgal species with fi ve dominant species: Polysiphonia sp., Padina minor, Ulva compressa, Gelidium pusillum, and Lobophora variegata. The abundance of Polysiphonia sp. was signifi cantly higher inside damselfi sh territory than outside. In contrast, the abundances of Gelidium pusillum, Padina minor, and Ulva compressa were slightly higher outside the territory. It might be perhaps because their feeding behavior, territorial defense, and farming activities altered the benthic community. These damselfi shes exclude other herbivorous fi shes from their territories and remove unpalatable algae and maintain their algal food crop. For species diversity, there was no signifi cant difference between algal species diversity outside and inside damselfi sh territories. Our results indicated that damselfi shes have a strong effect on algal abundance and composition.
Epidemiology and Antibiotic Sensitivity Patterns in Pyogenic Bone and Joint Infections in Children
Authors:   Department of Orthopaedics, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India., Sharma Amit , Gopinathan G Nirmal Raj ,   Department of Orthopaedics, Postgraduate Institute of Medical Education and Research, Chandigarh, India., Sharma Garima ,   Department of Microbiology, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India., Sharma Pallavi ,   Department of Obstetrics and Gynaecology, Government Medical College Hospital, Chandigarh, India., Negi Sange ,   Department of Orthopaedics, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India.
Published: January 2024

Staphylococcus aureus is the most common organism causing paediatric bone and joint infections accounting for 86% of pus culture-positive cases. Methicillin resistant staphylococcus aureus (MRSA) has become a major challenge in the tertiary care setting as the majority (56%) of all pus culture postive cases were MRSA. The male to female ratio in these infections was approximately 2:1. The lower limbs were affected in the majority of children with osteomyelitis (OM) with hip joint being the commonest (50%) followed by the knee. Broad spectrum antibiotics were used emperically in 40% of cases prior to referral to a tertiary care centre. MRSA infections were associated with a higher likelihood of complications. Keywords: Paediatric, Pyogenic, Bone and joint infections, Antibiotic practices