bluuebunny/crossref_metadata_2025 huggingface dataset:
Electronic Educational Resources as a New Component of a Traditional Educational Process
Authors: Melievna Makhmudova Dilfuza
Published: December 2022

Modern educational politics of our country is directed to formation of a new type of intellect, new pedagogical paradigms of teaching and upbringing, and also to the investigating cognitive-creative potential of person. In this, electronic teaching resources, electronic libraries play great meaning (role). Electronic teaching resources help to conduct teaching in a new qualitative level. Electronic informational resources may be used as a component of traditional teaching process
The Relationship Between Self Regulated Learning and Academic Stress on Students Taking Skipsi Course at FPIP 2016/2017 Universitas Muhammadiyah Sidoarjo
Authors: Fatmawati Fatmawati , Dewanti Ririn
Published: December 2022

Academic stress is stress related to educational activities that occur during the education period caused by demands that arise when a person is in education. This study aims to determine the relationship between self-regulated learning and academic stress in students taking thesis courses at FPIP in 2016. / 2017 Muhammadiyah University of Sidoarjo. This research is a type of quantitative research with a correlation approach. The population of this study were students who took the 2016/2017 thesis course at FPIP with a total of 387 students, with a research sample of 186 students taking 2016/2017 courses at FPIP, which were taken using a quota sampling technique. The data collection method used a Likert-model psychological scale, namely the academic stress scale (21 items, a = 0.834) and the self-regulated learning scale (68 items, a = 0.949). The data analysis used is the analysis with Pearson Product Moment correlation technique using the SPSS 18 for windows program. The results showed a negative relationship between self-regulated learning and academic stress in students who took thesis courses at FPIP in 2016/2017 Muhammadiyah University of Sidoarjo with a correlation coefficient of -0.376 with ρ = 0.000 (ρ <0.05). The correlation coefficient value shows that there is a significant negative relationship, meaning that the higher the self-regulated learning, the lower the academic stress. Conversely, the lower self-regulated learning, the higher the academic stress. Self regulated learning provides an effective contribution of 14.1% to academic stress
The Influence of Price, Product Quality, and Brand Image of Bear Brand Milk on Purchase Decisions during a Pandemic Period for Students of Muhammadiyah University of Sidoarjo Management Study Program
Authors: Anisa Nur Fauziatin , Sari Herlinda Maya Kumala
Published: December 2022

This thesis is not published. Faculty of Business, Law and Communication Sciences, University of Muhammadiyah Sidoarjo. The purpose of thispstudy is toodetermine andanalyze the effect of Price, Production Quality, and Brand Image on Bear Brand milk purchasing decisions for students of Management Study Program, Muhammadiyah University of Sidoarjo. This study uses quantitative methods. Data collection techniques using questionnaires, distributed to 100 students Muhammadiyah University of Sidoarjo. The data analysis technique used in this research is non-random sampling using purposive sampling with the help of SPSS (Statistical Program for Social Science) version 25. The results of this study indicate that the price variable has a significant effect on purchasing decisions, the product quality variable has a significant effect on purchasing decisions, brand image has a significant effect on purchasing decisions, and the variables price, product quality, and brand image have a significant effect on purchasing decisions for bear brand milk in college students. Muhammadiyah University of Sidoarjo
The Relationship Between Self-Regulation and Academic Procrastination in Grades 7 & 8 Students of Muhammadiyah 8 Middle School Tanggulangin
Authors: Hasyim Adji , Nastiti Dwi
Published: December 2022

This study aims to identify and provide an explanation of the relationship between self-regulation and academic procrastination in class VII & VIII students of SMP Muhammadiyah 8 Tanggulangin. This research method is quantitative with the subjects of class VII & VIII students totaling 99 students. Determination of the subject using a saturated sampling technique where sampling is done by considering certain characteristics. The variables in this study were self-regulation and academic procrastination. Data collection in this study used two psychological preparation scales, namely the Likert scale for self-regulation variables and academic procrastination made by the researcher. The hypothesis in this study is that there is a negative relationship between self-regulation and academic procrastination. Analysis of the data in this study using statistical product moment correlation test with the help of SPSS 18 for Windows. The results of this study indicate that there is a negative relationship between self-regulation and academic procrastination in class VII & VIII SMP Muhammadiyah 8 Tanggulangin with a value of r = -0.265 with a significance value of 0.000 (P<0.05). This means that there is a significant negative relationship between self-regulation and academic procrastination in class VII & VIII students of SMP Muhammadiyah 8 Tanggulangin. So, the results of the initial hypothesis that the researcher proposes can be accepted.
Habituation of Religious Character Based on Al-Islam and Kemuhammadiyahan in Elementary Schools
Authors: Rosuli Izzatur , Amrullah Muhlasin
Published: December 2022

This study aims to determine the habituation of religious character based on Al Islam and Kemuhammadiyahan in Elementary School.  The research method  uses a descriptive qualitative approach, wherea data collected is data in the form of words, images, and not numbers.  The data collection techniques used by researchers are triangulation techniques, namely observation, interviews, and documentation. In this study, researchers found that at SD Muhammadiyah 1 Wringinanom, they used to a religious character based on Al Islam and Kemuhammadiyahan. There are supporting and inhibiting factors in its implementation. The supporting factors are the support of parents, the joint commitment of school residents, adequate facilities. The inhibiting factors are the different backgrounds of students, the social environment of students, and the lack of awareness of students.
Factors Affecting Interest in Stock Investment for Millennial Generation (Study on Accounting Study Program Students, University of Muhammadiyah Sidoarjo)
Authors: Rosita Siti Mei Nur , Hanif Aisha
Published: December 2022

This study aims to determine whether the variables of investment knowledge, investment motivation, financial literacy, and risk affect interest in stock investment. The research method used is quantitative with multiple linear regression analysis as an analytical tool, to prove the hypothesis used by testing the validity, reliability, coefficient of determinant and multiple linear regression analysis with significant test f and t. The sampling technique used is purposive sampling by distributing questionnaires via google form so that it gets 82 respondents and this research was conducted on students of the Accounting Study Program, Muhammadiyah University of Sidoarjo. The results show that the results of the F test of the investment interest variable can be influenced by the variables of Investment Knowledge (X1), Investment Motivation (X2), Financial Literacy (X3) and Risk (X4) together. By partial test, the variables of Investment Knowledge (X1), Investment Motivation (X2), Financial Literacy (X3) and Risk (X4) have a significant effect on investment interest.
Shaping Student Discipline Characters Through the Role of Teachers at Muhammadiyah 2 Sidoarjo Elementary School
Authors: Mujahidin Abdullah , Rindaningsih Ida
Published: December 2022

Discipline is the attitude of obeying the rules in forming moral character. Therefore, discipline becomes an important issue. In this regard, the role of teachers in schools is very necessary to form a strong student character. The aims of this study are to: (1) play the role of the teacher in shaping the discipline of fifth grade students of SD Muhammadiyah 2 Sidoarjo, (2) support the supporting factors and the formation of disciplinary character of students in class V of SD Muhammadiyah 2 Sidoarjo. A qualitative approach is a type of qualitative descriptive research used to achieve the above objectives. The central tool is the researcher himself and the data collection techniques used are observation, interviews and documentation. Data analysis by organizing data, presenting data, and drawing conclusions. The results showed that (1) the teacher's role in shaping the discipline character of fifth grade students at SD Muhammadiyah 2 Sidoarjo included compliance with rules, punctuality, and responsibility in carrying out tasks; ricefield. (2) The factors that shape the character of this field include supporting school programs, building good partnerships in the school environment, and playing an active role in student development to support teachers and parents. In addition, barriers include lack of proper parental cooperation, limited teacher supervision of students, influential peers, and lack of technology use.
The Effect of Religiosity, Understanding of Taxation and Love of Money on Perceptions of Tax Evasion with Risk Preference as a Moderating Variable
Authors: Rusilawaty Yessy , Ernandi Herman
Published: December 2022

This study aims to determine the effect of religiosity, understanding of taxation and love of money on perceptions of tax evasion with risk preference as a moderating variable. Study on Accounting and Management Students at Muhammadiyah University of Sidoarjo. The analytical tool used is tabulation of the questionnaire, data collection in the form of validity and reliability tests. The hypothesis in this study is the influence of religiosity, understanding of taxation and love of money on perceptions of tax evasion with risk preference as a moderating variable. By testing the hypothesis using the SmartPLS analysis tool. The results obtained based on the validity test showed that all questions on the questionnaire were declared valid. To test the reliability of all variables the Composite Realibility value or Cronsbach's Alpha value is declared reliable. And for hypothesis testing based on R-Square and T-Statistic values, allphypothesesparepaccepted, the resultspstatepthat the influence of religiosity, understanding of taxation and love of money moderated by risk preference has an effect on perceptions of tax evasion.
Leveraging family history data to disentangle time-varying effects on disease risk using lifecourse Mendelian randomization
Authors: Richardson Tom G , Urquijo Helena , Holmes Michael V , Smith George Davey
Published: December 2022

Lifecourse Mendelian randomization is a causal inference technique which harnesses genetic variants with time-varying effects to develop insight into the influence of age-dependent lifestyle factors on disease risk. Here, we apply this approach to evaluate whether childhood adiposity has a direct consequence on 8 major disease endpoints by analysing data on first-degree relatives from the UK Biobank study. Our findings suggest that, whilst childhood adiposity increases later risk of outcomes such as heart disease (odds ratio (OR) = 1.15, 95% CI = 1.07 to 1.23, P = 7.8x10− 5) and diabetes (OR = 1.43, 95% CI = 1.31 to 1.56, P = 9.4x10− 15), these findings are likely attributed to a sustained influence of adiposity for many years over the lifecourse. Likewise, we found evidence that sustained adiposity over the lifecourse increases risk of lung cancer, which was partially mediated by lifetime smoking index. In contrast, using family history data provided evidence that being overweight in childhood may have a protective effect on risk of breast cancer (OR = 0.87, 95% CI = 0.78 to 0.97, P = 0.01), corroborating findings from observational studies and large-scale genetic consortia. Large-scale family disease history data can provide a complementary source of evidence for epidemiological studies to exploit, particularly given that they are likely more robust to sources of selection bias (e.g. survival bias) compared to conventional case control studies. Leveraging these data using approaches such as lifecourse Mendelian randomization can help elucidate additional layers of evidence to dissect age-dependent effects on disease risk.
Paracoccus marinaquae sp. nov., isolated from coastal water of the Yellow Sea
Authors: Xue Hua-Peng , Fu Zi-Yue , He Wei , Wang Lei , Li Wen-Jun , Zhang Ai Hua , Huang Jian-Ke , Zhang Dao-Feng , Zhao Zhe
Published: December 2022

A Gram-stain-negative, non-motile and coccoid bacterial strain, designated XHP0099T, was isolated from the coastal water of the Yellow Sea, China. Growth occurred at 20–37°C (optimum, 28°C), pH 5.0–9.0 (optimum, pH 7.0–8.0), and with 0–7.0% NaCl (optimum, 2.0–3.0%). Phylogenetic analysis based on 16S rRNA gene sequences showed that strain XHP0099T was related to members of the genus Paracoccus and shared the highest sequence similarity with “P. siganidrum” M26 (98.2%), followed by P. alkanivorans 4-2T (97.6%) and P. alkenifer DSM 11593T (97.4%). The average nucleotide identity, amino acid identity and digital DNA–DNA hybridization values of strain XHP0099T against related members in the genus Paracoccus were below the cut-off points proposed for delineation of a novel species. The major cellular fatty acids (＞10%) were summed feature 8 (C18:1 ω7c/C18:1 ω6c), and C18:0. The major isoprenoid quinone was Q-10 and the polar lipids contained diphosphatidylglycerol (DPG), phosphatidylglycerol (PG), phosphatidylethanolamine (PE), phosphatidylcholine (PC), aminolipid (AL) and unidentified polar lipids (L). The G+C content of the genomic DNA of strain XHP0099T was 66.0%. Further genomic analysis suggested that strain XHP0099T harbored gene clusters for formaldehyde and the XoxF-type methanol oxidation and type 1 Calvin cycle, which could confer the methylotrophy pathway. Based on the phenotypic, phylogenetic, biochemical and chemotaxonomic analysis, strain XHP0099T represents a novel species of the genus Paracoccus, for which the name Paracoccus marinaquae sp. nov. is proposed. The type strain is XHP0099T (=JCM 34661T=GDMCC 1.2414T=MCCC 1K05846T).
Response of rumen fermentation and microbiota to high-energy diet in fattening sheep
Authors: Ge Ting , Yang Chen , Li Bo , Huang Xiaoyu , Zhao Leiyun , Zhang Xiaoqiang , Tian Lintao , Zhang Enping
Published: December 2022

In mutton sheep production, higher dietary energy is often used to achieve better animal performance. Whereas, changing the diet formula will affect rumen fermentation and microbiota of ruminants. In this study, we investigated the effect of dietary energy on rumen fermentation and ruminal microbiota in fattening sheep. Fifteen 2-month-old white-headed Suffolk sheep (♂) × Hu sheep (♀) crossbred lambs were randomly divided into 3 treatments: 8.67 MJ/kg (LE, n=5), 10.38MJ/kg (CON, n=5), and 12.31 MJ/kg (HE, n=5) based on the dietary energy of feeds fed. After 70 days of feeding, sheep were slaughtered, and the ruminal fluids were collected and analyzed to determine fermentation parameters, microbiota was determined using metagenomics sequencing. We found that there was no effect on the microbial cell protein (MCP) and butyric acid concentration was significantly high in the HE group. Metagenomic sequencing revealed that ACE and Chao indexes of the HE group were significantly decreased. Among the major classified taxa, 4 genera across all the kingdoms differed in relative abundance among the three dietary energy levels. Correlation analysis revealed that the relative abundances of Prevotella_brevis, Succiniclasticum_ruminis, Prevotellace-ae_bacterium, andLachnospiraceae_bacterium were significantly correlated with rumen fermentation. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis further showed high-energy diet increased lipid metabolism. The expression of the Carbohydrate Active enzymes (CAZy) gene indicated which participates in energy metabolism increased, but those which regulate plant cell wall degradation decreased in the HE group. These results suggest that a high-energy diet had limited influence on the rumen fermentation pattern. Whereas, a high-energy diet changes rumen microbiota composition which leading microbial lipid metabolism enhanced and crude fiber's metabolism capacities weakened. Our results provide scientific evidence for fattening sheep production.
Obstetric and neonatal outcomes: Antiseizure medication profile and seizure types in pregnant women in a vulnerability state, Brazil
Authors: Leite Magnúcia De Lima , Silva José Claudio da , de Oliveira Tales Lyra , Mota-Ortiz Sandra Regina , Almeida Daniel dos Santos , Toporcov Tatiana Natasha
Published: December 2022

Objectives: To describe obstetric and neonatal outcomes, antiseizure medication (ASM), and types of seizures in pregnant women with epilepsy (PWWE).
Methods: In this retrospective cohort study using data collected from the medical records obtained from high-risk maternity hospitals in Alagoas. PWWE and pregnant women without epilepsy (control group) between 2008 and 2020, aged <40 years with controlled or refractory seizures.
Results: The obstetric and neonatal outcomes observed in PWWE were pregnancy-related hypertension (PrH) (odds ratio [OR]=6.29; 95% confidence interval (CI)=3.50–11.30), vaginal bleeding (OR=2.54; 95% CI=1.15–5.59), preeclampsia (OR=8.04; 95% CI=2.22–29.10), oligohydramnyos OR=4,57; 95% CI=2.24–9,31), polyhydramnios (OR=7.55; 95% CI=1.55–36.65), miscarriage (OR=1.75;95% CI=1.16–2.63), stillbirth (OR=11,16; 95% CI=2.22–29.10), greater likelihood of PrH in those with generalized tonic-clonic seizures (GTCS) (OR=8.05; 95% CI=3.47–18.64), maternal ICU admission in those with GTCS and status epilepticus (OR=11.73; 95% CI=2.44–56.37 vs. OR=37.50; 95% CI=8.32–168.84, respectively) and phenytoin and lamotrigine use (OR=17.75; 95% CI=1.95–160.77 vs. OR=7.10; 95% CI=1.03–48.64). PWWE with GTCS had a higher chance for stillbirth (OR=3.41; 95% CI=1.03–11.28). and status epilepticus to deliver prematurely (OR=2.22; 95% CI=1.05–4.69). PWWE with status epilepticus using lamotrigine (OR=21,91; 95% CI=2.07–231.60). Phenobarbital(PB) with diazepam was commonly used by GTCS and status epilepticus (OR=12.04; 95% CI=1.43–101.47). Only 14% didn’t use ASM, 50.2% used monotherapy, and 35.8% polytherapy. PB was used (60.9%), and carbamazepine (25.2%).
Conclusion: This study described association to adverse obstetric and neonatal outcomes and severe seizure types in PWWE.
A New Criteria for Determining the Best Decomposition Level and Filter in Wavelet-based Data-driven Forecasting Frameworks- Validating Using Three Case studies on The CAMELS Dataset
Authors: Behbahani Mohamadreza Mazarei , Behbahani Amin Mazarei
Published: December 2022

Recently, numerous papers have been published in the field of using preprocessing models (e.g. Discrete wavelet) in Data-driven Forecasting Frameworks (DDFF). There are some unresolved problems in these models like using future data, boundary affected data, and miss selection of decomposition level and wavelet filter that cause an erroneous result. However, Wavelet-based Data-driven Forecasting Framework (WDDFF) solves these problems. The first two problems could be solved using Maximal Overlap Discrete Wavelet Transform (MODWT) and a trous algorithm (AT). As the best we know, there is no absolute solution for decomposition level and wavelet filter selection. Meanwhile, as a novel investigation, we are going to use Entropy to find a solution for these problems. We are using the concept of predictability of time series using entropy for determining decomposition level and suitable filter, to develop the Maximal Overlap Discrete Wavelet-Entropy Transform (MODWET) to apply in WDDFF correctly. We will reveal the effectiveness of MODWET through three real-world case studies on the CAMELS data set. In these case studies, we will forecast the streamflow of determined stations from one month ahead to prove the effectiveness of using preprocessing models on forecasting accuracy. The proposed model is a combination of Input Variable Selection (IVS), preprocessing model, and Data-Driven Model (DDM). In conclusion, we will show that MODWET- ANN is the best model. In addition, we will realize how good entropy could find decomposition level and filter, which solves the mentioned concerns about using WDDFF in real-world hydrological forecasting problems.
A new genome of an African weakly electric fish (Campylomormyrus compressirostris, Mormyridae) indicates rapid gene family evolution in Osteoglossomorpha
Authors: Cheng Feng , Dennis Alice B. , Osuoha Josephine , Canitz Julia , Kirschbaum Frank , Tiedemann Ralph
Published: December 2022

Background
Teleost fishes comprise more than half of the vertebrate species. Within teleosts, most phylogenies consider the split between Osteoglossomorpha and Euteleosteomorpha/Otomorpha as basal, preceded only by the derivation of the most primitive group of teleosts, the Elopomorpha. While Osteoglossomorpha are generally species poor, the taxon contains the African weakly electric fish (Mormyroidei), which have radiated into numerous species. Within the mormyrids, the genus Campylomormyrus is mostly endemic to the Congo Basin. Campylomormyrus serves as a model to understand mechanisms of adaptive radiation and ecological speciation, especially with regard to its highly diverse species-specific electric organ discharges (EOD). Currently, there are few well-annotated genomes available for electric fish in general and mormyrids in particular. Our study aims at producing a high quality genome and to use this to examine genome evolution in relation to other teleosts. This will facilitate further understanding of the evolution of the osteoglossomorpha fish in general and of electric fish in particular.
Results
A high quality weakly electric fish (C. compressirostris) genome was produced from a single individual with a genome size of 862Mb, consisting of 1,497 contigs with an N50 of 1,399 kb and a GC-content of 43.69%. Gene predictions identified 34,492 protein-coding genes, which is a higher number than in the two other available Osteoglossomorpha genomes of Paramormyrops kingsleyae and Scleropages formosus. A CAFE5 analysis of gene family evolution comparing 33 teleost fish genomes suggests an overall faster gene family turnover rate in Osteoglossomorpha than in Otomorpha and Euteleosteomorpha. Moreover, the ratios of expanded/contracted gene family numbers in Osteoglossomorpha are significantly higher than in the other two taxa, except for species that had undergone an additional genome duplication (Cyprinus carpio and Oncorhynchus mykiss). As potassium channel proteins are hypothesized to play a key role in EOD diversity among species, we put a special focus on them, and manually curated 16 Kv1 genes. We identified a tandem duplication in the KCNA7a gene in the genome of C. compressirostris.
Conclusions
We present the fourth genome of an electric fish and the third well-annotated genome for Osteoglossomorpha, enabling us to compare gene family evolution among major teleost lineages. Osteoglossomorpha appear to exhibit rapid gene family evolutiona, with more gene family expansions than contractions. The curated Kv1 gene family showed seven gene clusters, which is more than in other analyzed fish genomes outside Osteoglossomorpha. The KCNA7a, encoding for a potassium channel central for EOD production and modulation, is tandemly duplicated which may related to the diverse EOD observed among Campylomormyrus species.
Integrated Case Presentation Seminar: Bridging Parallel Fields to Improve Psychiatry and Psychology Learner Experience
Authors: Leffler Jarrod M. , Romanowicz Magdalena , Brennan Elle , Elmaghraby Rana , Caflisch Sara , Lange Hadley , Kirtley Alexander T.
Published: December 2022

Daily clinical practice of mental health professionals often requires interaction between providers from diverse training and professional backgrounds. Efforts to engage mental health trainees across disciplines are necessary and have had varied outcomes. The current study reviews the development and implementation of a monthly one-hour integrated case presentation seminar (ICPS) as part of independent psychology and psychiatry two-year fellowships at a Midwestern teaching hospital. The training integrated a semi-structured seminar to facilitate case presentation within a group setting. The focus of the seminar was to allow for exposure to conceptualization, diagnostic, and treatment strategies and skills, as well as science-based practice techniques for trainees. Learner survey results and the sustained offering of the seminar suggest the format and goals of the seminar are feasible and acceptable. Based on the current preliminary findings, similar training programs may find benefit in strategies to enhance integrated training opportunities for psychiatry and psychology trainees.
Investigating the effectiveness of the supportive-educational program, based on COPE model, on the quality of life and caregiver burden of family caregivers of heart failure patients: A randomized clinical trial study
Authors: Alaei Atefeh , Babaei Sima , Farzi Sedigheh , hadian Zahra
Published: December 2022

Background: Heart failure (HF) is one of the common and spreading diseases in the world, especially in developing countries. As HF symptoms progress, the need for care by the family increases in these people, so that it affects the quality of life and the caregiver burden of the family. The aim of the present study was to determine the effectiveness of the supportive-educational program, based on COPE care model, on the quality of life and caregiver burden of family caregivers of HF patients.
Method: This clinical trial was conducted on 90 caregivers of HF patients admitted to Chamran Hospital of Isfahan in 2021. Patients were selected using convenience sampling method and were divided into experimental (n=45 people) and control (n=45 people) groups based on random allocation (card method). The experimental group received problem-solving skills based on the four components of the COPE model (creativity, optimism, planning and expert advice) in six sessions during one month. In order to collect data, the 36-Item Short Form Survey (SF-36) and the Zarit Burden Interview (ZBI) were used in two groups before, after and three months after the intervention.
Results: There was a significant difference between the experimental and control groups in terms of gender (p<0.05), which was considered as a confounding factor. This confounding factor had no significant effect on the two components of quality of life and caregiver burden (p>0.05). There was a significant difference between the two groups in terms of mean scores of quality of life and care burden, immediately (75.99, 16.60) and three months after the intervention, respectively (78.78, 12.73) (p<0.05).
Conclusions: The results of the present study showed that the COPE model plays a significant role in increasing the quality of life and reducing the caregiver burden of caregivers of HF patients.
Trial registration: This study is registered by Iranian Registry of Clinical Trials with decree code: IRCT20211128053202N1on 2022-02-20.
Effects of epidural analgesia on gastric emptying in parturients monitored by ultrasound
Authors: Wu Wei , Bu Wenhao , Chen Lin , Yan rongrong , wan shengjun
Published: December 2022

Background:
Using B-ultrasound monitoring, we compared gastric emptying of semi-solid food between parturient women undergoing versus not undergoing epidural analgesia.
Methods
Eighty-six full-term, low-risk parturients were selected and divided into two groups according to epidural analgesia status: epidural analgesia group (LA, n = 66) and non-epidural analgesia group (NA, n = 20). The cross-sectional area of the gastric antrum (CSA0) was measured while fasting using B-ultrasound, and the time recorded as T0. The parturients in both groups then ate about 300 g millet congee (about 600 KJ). The CSAs of the gastric antra were measured by ultrasonography 60, 90, and 120 minutes after the experimental meal, these areas being recorded as CSA1, CSA2 and CSA3 and the corresponding time points as T1, T2, and T3. Pain scores of parturients at these four time points were recorded.
Results
CSA1, CSA2, and CSA3 were larger in the NA than in the LA group, and the gastric emptying time was longer in the NA than in the LA group (P < 0.05). Pain scores were higher in the NA than LA group at the three time points of T1, T2, T3 (P < 0.05).
Conclusions
Gastric emptying was faster in parturient women who undergo epidural analgesia than those who not. Pregnant women can safely eat small amounts of semi-solid food to meet their energy needs during delivery.
Braille Recognition by E-skin System based on Binary Memristive neural network
Authors: Liu Y. H. , Wang J. J. , Wang H. Z. , Liu S. , Wu Y. C. , Hu S. G. , Yu Q. , Liu Z. , Chen T. P. , Yin Y. , Liu Y.
Published: December 2022

Braille system is world widely used for visually impaired people for communication. However, there are still some visually impaired people who are not able to learn Braille system due to various factors, such as the age (too young or too old), damage of brain, etc. A wearable and low-cost Braille recognition system may substantially help these people recognize Braille or assist them in Braille learning. In this work, we fabricated polydimethylsiloxane (PDMS)-based flexible pressure sensors to construct an electronic skin (E-skin) for the application of Braille recognition. The E-skin mimics the human touch sensing function for collecting Braille information. The Braille recognition is realized with a neural network based on memristors. We utilize a binary neural network algorithm with only two bias layers and three fully connected layers. Such neural network design remarkably reduces the calculation burden and thus the system cost. Experiments show that the system can achieve a recognition accuracy of up to 91.25%. This work demonstrates the possibility to realize a wearable and low-cost Braille recognition system and a Braille learning-assistance system.
Piloting an ICU follow-up clinic to improve health-related quality of life in ICU survivors after a prolonged intensive care stay (PINA): Feasibility of a pragmatic randomised controlled trial
Authors: Drewitz Karl Philipp , Hasenpusch Claudia , Bernardi Christine , Brandstetter Susanne , Fisser Christoph , Pielmeier Katharina , Rohr Magdalena , Brunnthaler Vreni , Schmidt Konrad , Malfertheiner Maximilian , Apfelbacher Christian
Published: December 2022

Background
ICU survivors often suffer from prolonged physical and mental impairments resulting in the so called “Post-Intensive Care Syndrome” (PICS). The aftercare of former ICU patients affected by PICS in particular has not been addressed sufficiently in Germany so far. The aim of this study was to evaluate the feasibility of a pragmatic randomized trial (RCT) comparing an intensive care unit (ICU) follow-up clinic intervention to usual care.
Methods
This pilot study in a German university hospital evaluated the feasibility of a pragmatic RCT. Patients were assigned in a 1:1 ratio to an ICU follow-up clinic intervention or to usual care. The concept of this follow-up clinic was previously developed in a participatory process with patients, relatives, health professionals and researchers. We performed a process evaluation and determined acceptability, fidelity, completeness of measurement instruments and practicality as feasibility outcomes. The RCT’s primary outcome (health-related quality of life) was assessed six months after ICU discharge by means of the physical component scale of the Short-Form-12 self-report questionnaire.
Results
Principal findings related to feasibility were 85% consent rate (N = 48), 34% attrition rate (N = 41) and 77% completeness of outcome measurements. 41 participants (15 women, median age 60 years) were included of whom 66% completed the study (12/21 in the intervention group, 15/20 in the control group). Median length of ICU stay was 13 days and 85% (N = 41) received mechanical ventilation, median Sequential Organ Failure Assessment Score was nine. 62% of the intervention group (N = 21) fully completed all components of the intervention (fidelity). Six-month follow-up assessment was planned for all study participants and performed after 197 days (median). The primary effectiveness outcome (health-related quality of life) could be measured in 93% of participants who completed the study (N = 27).
Conclusion
The participatory developed intervention of an ICU follow-up clinic and the pilot RCT both seem to be feasible. We recommend to start the pragmatic RCT on the effectiveness of the ICU follow-up clinic.
Trial registration
ClinicalTrials.gov US NLM, NCT04186468, Submission: 02/12/2019, Registration: 04/12/2019, https://clinicaltrials.gov/ct2/show/NCT04186468
Moya-Moya like vasculitis secondary to sarcoidosis: a rare case report of concomitant ischemic infracts and sub-arachnoid hemorrhage
Authors: Zouari Rania , Saeid Mohamed Zakaria , Sassi Samia Ben
Published: December 2022

Background : Sarcoidosis is a rare idiopathic systemic inflammatory disease that mainly affects the lymph nodes, lungs, skin and eyes. Nervous system involvement is only seen in 5% of cases of sarcoidosis. Cerebral vasculitis, is particularly uncommon in patients with sarcoidosis, with serious outcome.
Case presentation : We reported the case of a 55 years-old female who developed a severe hemicranial headache with nausea and vomiting. She had a history of erythema nodosum. The clinical examination showed left arm weakness and central facial paralysis, along with brisk tendon reflexes and arthralgia. Brain MRI showed a moderate subarachnoid hemorrhage, multiple acute lacunar infracts, and a large ischemic stroke over the right superficial sylvian territory; and MR angiography revealed a Moya-Moya like vasculopathy pattern and the occlusion of intracranial internal carotid arteries. Extensive laboratory workup including infectious serologies and vasculitis screen was negative; and Angiotensin-converting enzyme levels were normal. Findings in the CT chest and abdomen scan, and Broncho alveolar lavage confirmed the diagnosis of sarcoidosis.
Conclusions : Cerebrovascular manifestation are uncommon in sarcoidosis. Multiple factors seem to be involved in the pathogenesis of sarcoidosis related vasculopathy. The diagnosis should be considered when recurrent infracts and hemorrhage are encountered in a patient having systemic symptoms of sarcoidosis.
A novel c.64G>T (p.G22C) NR5A1 mutation in a Chinese adolescent with 46, XY disorders of sex development: a case report
Authors: Zhang Dan , Wang Dajia , Tong Yajie , Li Mingyu , Meng Lingzhe , Song Qiutong , Xin Ying
Published: December 2022

Background
Adolescents with 46, XY disorders of sex development (DSD) face additional medical and psychological challenges. To optimize management and minimize hazards, correct and early clinical and molecular diagnosis is necessary.
Case presentation:
We report a 13-year-old Chinese adolescent with absent Müllerian derivatives and suspected testis in the inguinal area. History, examinations, and investigations were available for clinical diagnosis, and subsequent genetic sequencing was employed for molecular diagnosis. We identified a novel variation in nuclear receptor subfamily 5 group A member 1 (NR5A1) [c.64G > T (p.G22C)] in the patient. In vitro functional analyses of the novel variant suggested no impairment to NR5A1 mRNA or protein expression relative to wild-type, and immunofluorescence confirmed similar localization of the NR5A1 mutant to the cell nucleus. However, we observed decreased DNA-binding affinity by the NR5A1 variant, while dual-luciferase reporter assays showed that the mutant effectively downregulated the transactivation capacity of anti-Müllerian hormone. We described a novel NR5A1 variant and demonstrated its adverse effects on the functional integrity of the NR5A1 protein resulting in serious impairment of its modulation of gonadal development.
Conclusions
This study provides deeper insights into the NR5A1 mutational spectrum.
Role of trombe walls on the reduction of energy load and sustainable development in an eco-resort residential building in Binalood region with a cold and dry climate
Authors: Sady Hamed , Rashidi Saman , Rafee Roohollah
Published: December 2022

Trombe wall is a passive strategy that reduces the energy consumption in buildings and helps for sustainable development of residential sector. Applying these walls is very important in areas that need heating load in winter. In this study, a set of trombe walls is evaluated for the energy management of a residential building under real conditions in Binalood region with a cold and dry climate. In order to study the potentials of trombe wall, four different designs, including C, T3SG, T4SG and T designs, for trombe walls are considered. Trombe walls of all four suggested designs are exposed to outdoor conditions and installed at 17 places on the southern walls of the residential building. The occupied surface by these walls is 60% of the total area of the southern walls. Therefore, using the southern natural light is possible for all 17 places. The obtained results show that when the shade (Blinds) and ventilation values are considered on the common wall with specific seasonal and daily functions, the use of trombe walls in all designs leads to a significant reduction in the heating load of the entire building. Results show that during five months of the year, the trombe walls with C, T3SG, T4SG and T designs lead to the reductions of 4710, 5400, 5112 and 5559, kWh in the heating load of the building, respectively. In addition, the most optimal mode, i.e. design T with three directions of radiation absorption, trapezoidal cross-section, and thicker storage wall, leads to the greatest decrease (1637 kWh) in heating load in January.
Implementation and Evaluation of Personal Genetic Testing As Part of Genomics Analysis Courses in German Universities
Authors: Slosarek Tamara , Ibing Susanne , Schormair Barbara , Heyne Henrike O. , Böttinger Erwin P. , Andlauer Till F. M. , Schurmann Claudia
Published: December 2022

Purpose
Due to the increasing application of genome analysis and interpretation in medical disciplines, professionals require adequate education. Here, we present the implementation of personal genotyping as an educational tool in two genomics courses targeting Digital Health students at the Hasso Plattner Institute (HPI) and medical students at the Technical University of Munich (TUM).
Methods
We compared and evaluated the courses and the students’ perceptions on the course setup using questionnaires.
Results
During the course, students changed their attitudes towards genotyping (HPI: 79% [15 of 19], TUM: 47% [25 of 53]). Predominantly, students became more critical of personal genotyping (HPI: 73% [11 of 15], TUM: 72% [18 of 25]) and a majority of students stated that genetic analyses should not be allowed without genetic counseling (HPI: 79% [15 of 19], TUM: 70% [37 of 53]). Students found the personal genotyping component useful (HPI: 89% [17 of 19], TUM: 92% [49 of 53]) and recommended its inclusion in future courses (HPI: 95% [18 of 19], TUM: 98% [52 of 53]).
Conclusion
Students perceived the personal genotyping component as valuable in the described genomics courses. The implementation described here can serve as an example for future courses in Europe.
Coping strategies among adolescents and young adults living with HIV/AIDS in Accra-Ghana
Authors: Dake Selom , Bonful Harriet Affran , Asamoah Alexander , Arthur Hannah Ama , Mwintuu Linus , Asampong Emmanuel , Kretchy Irene A. , Anum Adote
Published: December 2022

Background
Living with HIV/AIDS is remarkably stressful and has an adverse effect on one’s physical and mental health. In Sub-Saharan Africa, the introduction of highly active anti-retroviral therapy has led to an increased number of children with perinatal acquired HIV who are living into adolescence and adulthood. Developing strategies to cope with HIV becomes imperative, especially among these adolescents. The study determined the factors that influence coping strategies among adolescents living with HIV.
Methods
An analytic cross-sectional design was used. 154 adolescents aged 10–19 years living with HIV were systematically sampled at the Fevers Unit of Korle Bu Teaching Hospital from June to December 2021. The adolescent version of the KidCope was used to assess the choice of coping strategies. Stata 16 was used to determine associations between independent variables and the coping strategies identified. Only variables that were significant at p = 0.1 or less in the crude model were used to run the adjusted regression model. The level of significance was set at p = 0.05 with a 95% confidence interval.
Results
The mean age of participants was 19.2 (95%CI-18.7-19.6) years with 51.9% (80/154) of participants being males. A majority, 57.1% (95%CI-52.3%-63.4%) of the participants employed positive coping with 87.0% (135/154) using cognitive restructuring strategy. In an adjusted linear regression model, participants coping strategies were significantly associated with their age 0.96 (95%CI 0.51–1.76, p = 0.046), educational level (p = 0.029), parental status (p = 0.045), caregiver (p = 0.014) as well as dealing with stigma and discrimination (p = 0.008).
Conclusion
Participants largely adopted positive coping strategies in managing the disease. Factors that influenced the choice of coping strategies were increasing age, higher levels of education, and the presence of both parents as caregivers. The importance of a good social support structure and pursuing further education needs to be emphasized in counselling adolescents living with HIV as it promotes the choice of positive coping strategies.
An investigation of the level of stigma and the factors influencing it in the rehabilitation of young and middle-aged stroke patients
Authors: Zheng Zixiu , Song Runluo , Zhao Yunxiao , Lv Hongxia , Wang Yanqing , Yu Cong
Published: December 2022

Background
There are few reported studies on stigma in young and middle-aged stroke patients during the rehabilitation period, however, the rehabilitation period plays a key role in the patients' disease regression. Exploring the level of stigma and the influencing factors in young and middle-aged stroke patients during the rehabilitation period is crucial for determining how to reduce the level of stigma and improve the patients' motivation for rehabilitation treatment. Therefore, this study investigated the level of stigma in young and middle-aged stroke patients and analyzed the factors influencing stigma in order to provide a reference or basis for healthcare professionals to develop effective and targeted stigma intervention programs.
Methods
Using a convenience sampling method, 285 young and middle-aged stroke patients admitted to the rehabilitation medicine department of a tertiary care hospital in Shenzhen, China, from November 2021 to September 2022 were selected and surveyed using a general information questionnaire, the Stroke Patient Stigma Scale, the Barthel Index, and the Positive and Negative Emotions Scale, and multiple linear regression and smoothed curve fitting were used to analyze the factors influencing the stigma of young and middle-aged stroke patients during the rehabilitation period.
Results
Total stigma score of 45.08 ± 11.057, univariate analysis of age, occupation, education level, monthly income before illness, type of health insurance, chronic illness status, primary caregiver, Barthel Index, positive and negative emotion as factors influencing stigma. Multiple linear regression showed that age, monthly income before illness, the Barthel Index, positive and negative emotions were independent influences on stigma in young and middle-aged stroke patients, explaining 58.0% of the total variance in stigma. A smoothed curve fit revealed a curvilinear relationship between the above influences and stigma.
Conclusion
Young and middle-aged stroke patients have a moderate level of stigma. Medical staff should focus on young patients aged 18–44 years, those with high monthly income before the stroke, those with poor self-care ability, and those with low positive and high negative emotion scores, and conduct early assessments and adopt targeted intervention programs according to the influencing factors to reduce the stigma of young and middle-aged stroke patients, improve their motivation for rehabilitation, and help them return to their families and society as soon as possible.
Exploring Effortful Control as a Moderator of the Relationship Between Negative Affect and Child Psychopathology
Authors: Osborne Hanna S. , Palumbo Isabella M. , Tone Erin B.
Published: December 2022

The present study examined unique and interactive effects of effortful control (self-report vs. task-based) on the relationship between negative affect and dimensions of psychopathology in a group of children from the ABCD Study® aged 9–11 (n = 5,432). Results demonstrate that the reactive temperament factor of negative affect showed strong and positive significant associations with both dimensions of psychopathology, while the regulative factor of effortful control showed a significant negative association with both dimensions of psychopathology via Flanker, and a significant positive association with both dimensions of psychopathology via the EATQ-R. These findings raise the possibility that early assessment of effortful control may aid in the identification of early risk profiles for psychopathology and that interventions aimed at maximizing flexible deployment of effort control could help to reduce children’s risk of developing psychopathological symptoms.
Calibration of three-dimensional hot-film data using a collocated sonic anemometer
Authors: Freire Livia , Chamecki Marcelo , Patton Edward
Published: December 2022

In this study, we evaluate hot-film data and test an in situ calibration method from simultaneous sonic anemometer measurements. The details of the calibration are provided, and its performance is validated by comparing results of spectra and structure functions with standard wind-tunnel data and model spectra. A single 3h block of data was selected, containing 33 subblocks of 2 min data without gaps, whose statistics were averaged to provide smooth results. This block was measured above canopy under stable conditions, and it corresponds to a Taylor Reynolds number Reλ ≈ 1550. The agreement with wind tunnel results for a similar Reλ and with model predictions provides a validation for the proposed in situ calibration method. Furthermore, the results indicate a presence of the bottleneck effect in the lateral and vertical spectra, in addition to a lack of inertial range in the second-order structure function due to the low Reynolds number.