bluuebunny/crossref_metadata_2025 huggingface dataset:
Rapidly growing adenosquamous carcinoma in the pancreatic tail discovered upon its resection for cervical tuberculous lymphadenitis: A case report
Authors: Ota Hideo , Hoshino Hiromitsu , Ogisu Kyohei , Jokoji ryu , Yamashita Shinya , Ikushima Hirofumi , Arisaka Yoshifumi , Mizuno Hitoshi
Published: March 2024

Cancer (including pancreatic adenocarcinoma) can develop within one year of tuberculosis infection. However, it is unclear whether tuberculosis infection increases the risk of developing pancreatic adenosquamous carcinoma (ASCP), an extremely rare cancer with a poorer prognosis than pancreatic ductal adenocarcinoma (PDAC). Herein, we report a resected, rapidly growing adenosquamous carcinoma case of the pancreatic tail associated with cervical tuberculous lymphadenitis. The patient is a 57-year-old woman. An excisional biopsy of the swollen right cervical lymph nodes revealed tuberculous lymphadenitis. One month after the biopsy, an abdominal computed tomography scan showed a 2.0 cm (diameter) ischemic tumor in the pancreatic tail. The tissue obtained using endoscopic ultrasonography-guided fine-needle aspiration led to the pathological diagnosis of ASCP. Two months after the biopsy, the tumor had grown to 3.5 cm (diameter), and invasion of the stomach and colon was suspected. A distal pancreatectomy, splenectomy, partial gastrectomy, and transverse colectomy were performed. The final diagnosis was ASCP (4.7 cm, pT3, pN0, cM0, and p Stage IIA). Postoperative adjuvant combination chemotherapy combined with antituberculosis drugs was administered orally. We report the first case of a rapidly growing adenosquamous carcinoma resected from the pancreatic tail in association with cervical tuberculous lymphadenitis. Additional evidence is required to confirm that tuberculosis infection increases the risk of developing pancreatic adenosquamous cell carcinoma because its involvement in squamous cell metaplasia has not been proven. Patients with ASCP who underwent resection and adjuvant chemotherapy without early recurrence may have a 5-year survival rate similar to that of patients with PDAC.
Functional genomics evaluation of Levilactobacillus brevis strain DY55bre acquired from a lactic acid fermented beverage to further understand its biotechnological and probiotic potential
Authors: YETİMAN Ahmet E.
Published: March 2024

Levilactobacillus brevis is a significant member of lactobacilli due to its remarkable industrial and probiotic features. In this study, the L. brevis DY55bre strain was isolated from a lactic acid-fermented beverage known as "shalgam". Its genome size was 2.485.670bp, with a GC content of 45.72%. It is predicted to possess 2699 coding sequences, including 82 tRNA, 7 rRNA, 3 ncRNA, 42 CRISPR spacers, and 155 pseudogenes. Unlike previous research, the DY55bre genome only has one CAS system, Type-1E. The clusters of orthologous groups (COGs) comparison and pangenome analysis were performed using other genomes of L.brevis. Like other obligate heterofermentative lactobacilli, DY55bre has araBAD operon but no 1-phosphofructokinase(pfk) enzyme. Further, it can produce lactic acid, acetic acid, ethanol, 1-propanol, propanal, butane-2,3-diol, acetaldehyde, acetoin, and diacetyl as an outcome of carbohydrate metabolism. On the other side, DY55bre has the ability to produce the amino acids L-asparagine, L-aspartate, L-glutamine, L-glutamate, S-Adenosyl-L-methionine, citrulline, arginine, serine, glycine, and GABA. These amino acid and carbohydrate metabolism products are valuable due to their economic value and health benefits to humans and animals. Finally, probiogenomic assessment results demonstrated that L. brevis DY55bre has gut adaption features that allow it to withstand a wide range of stressors.
Examining Windows File System IRP Operations with Machine Learning for Ransomware Detection
Authors: Xu Bingyan , Wang Shukai
Published: March 2024

This study introduces an innovative approach to ransomware detection on Windows operating systems by leveraging Generative Adversarial Networks (GANs) to analyze file system I/O Request Packet (IRP) operations. The proposed method demonstrates a significant improvement in identifying ransomware activities through the dynamic monitoring of IRP operations, distinguishing between benign and malicious behaviors with high accuracy. The research highlights the application of GANs as a powerful tool in cybersecurity, capable of adapting to evolving ransomware tactics without the need for predefined threat signatures. Through rigorous testing, the model showcased notable advancements over traditional detection methods, indicating its potential to enhance real-world cybersecurity defenses. The findings suggest a shift towards more adaptive, machine learning-based solutions for combating the increasing complexity of cyber threats.
Risk factors for the development of arterial hypertension in children and young people in present-day developments
Authors: Ignatenko G. A. , Dubovaya A. V. , Naumenko Yu. V. , Dudchak A. P. , Sosna V. V.
Published: March 2024

In modern society, there is an intensive increase in the incidence of hypertension among young people, which is mainly due to lifestyle features and associated risk factors.

   Purpose. To analyze the results of Russian and foreign scientific research concerning the study of risk factors in the development of hypertension in children and young people.

   Material and methods. A qualitative analysis of the current data available in the literature on the risk factors of hypertension and its prevention has been carried out.

   Results. It has been established that the occurrence of arterial hypertension in childhood is influenced not only by hereditary factors, but also by a number of environmental risk factors.

   Conclusion. Further research is needed to study new and established risk factors that need to be considered when conducting primary prevention of the disease in children and young people from the high-risk group.
Mitochondrial dynamics and the significance of its disturbances in the development of childhood diseases. Part I. Physiological and neurological aspects
Authors: Sukhorukov V. S. , Baranich T. I. , Egorova A. V. , Fedorova E. N. , Skvortsova K. A. , Kharlamov D. A. , Krapivkin A. I.
Published: March 2024

In recent years, the dynamics of mitochondrial transformations in cells have been of more concern to both representatives of basic science and researchers in the field of applied medicine. A growing number of observations demonstrate the important regulatory influence of mitochondrial dynamics on a variety of physiological and pathological processes in many, if not all, organ and tissue structures. The prospects for studying the features and regulators of these processes for understanding the pathogenesis of diseases, developing their new biomarkers, as well as treatment technologies seem increasingly significant.

   The purpose of this article is to review the facts obtained regarding mitochondrial dynamics, which, from the authors’ point of view, deserve the attention of pediatricians.

   The volume of relevant information turned out to be too extensive to fit into one article, which forced it to be divided into several successive publications. The first part provides information about the main processes included in the concept of “mitochondrial dynamics,” the importance of maintaining the balance of the latter for ontogenesis and tissue homeostasis, as well as data on its disturbances in diseases of the nervous system in children.
Formation of cognitive processes in children with autism. Part I. Epigenetic mechanisms
Authors: Glotov O. S. , Chernov A. N. , Suchko P. A. , Eismont Yu. A. , Mayorova L. A.
Published: March 2024

Autism and autism spectrum disorders are neuropsychiatric diseases that begin to appear in children under 3 years. Over the past decade, the number of children with autism spectrum disorders has increased more than in 10-fold and continues to grow, accounting for 1–2 % of the world’s population. Currently, the diagnosis of autism spectrum disorders is based only on clinical and behavioral tests, and there are no biological and genetic markers that could contribute to the early detection of this disorder. The review, based on the analysis of modern literature data about epigenetic mechanisms which associated with autism, examines the influence of the DNA methylation profile in the formation of cognitive impairment and the possibility of using genes and their methylation status as diagnostic biomarkers in children with autism spectrum disorders. Literature data analysis shows that disorders of attention, speed of information processing, working memory, learning are based on genetic and epigenetic (methylation) changes in the expression of many genes: BDNF, CAPS2, CNTNAP2, GABRB3, FMR1, FOXP1, GTF2I, HSD11B2, MECP2, NF2, NGF, NR3C1, OXTR, PAK2, RELN, SLC6A4, UBE3A, etc. Most of these genes undergo hypermethylation, reducing the expression of its proteins, which impairs the development and formation of the nervous system in autism. In contrast, other genes are associated with methylation and oxidative stress are hypomethylated in autism spectrum disorders. Assessing the expression levels and methylation status of these genes can serve as genetic and epigenetic biomarkers for the differentiation and diagnosis of clinical symptoms, autism spectrum disorders severity, and facilitate the development of new treatments and rehabilitation procedures.
Adverse anthropogenic factors – a threat to the genetic and somatic health of children
Authors: Yurieva E. A. , Dlin V. V. , Kushnareva M. V. , Baleva L. S. , Sipyagina A. E. , Karakhan N. M. , Dantsev I. S.
Published: March 2024

The authors, based on a large number of studies (including their own) regarding the toxic effects of heavy and radioactive metals on children of different ages and with varying degrees of chronic exposure to such metals, present the risks of developing somatic and genetic diseases. The main mechanisms of the influence of the radiation factor on the child’s body and the causes of the formation of radiation-induced diseases are shown.
Erythema nodosum in children
Authors: Khaertynov Kh. S. , Anokhin V. A. , Makarova K. A. , Khaliullina S. V. , Bulatova A. Kh. , Yumasheva S. Yu.
Published: March 2024

Erythema nodosum, which is often associated with infectious diseases, is one of the rare skin manifestations in the practice of pediatricians and pediatric infectious disease specialists.

   Purpose. The purpose was to study the clinical and laboratory manifestations of erythema nodosum in children.

   Material and methods. The study included 17 children with erythema nodosum aged 2 to 17 years who were hospitalized at the City Children’s Hospital No. 1 of Kazan.

   Results. In 6 (35 %) children, elevated values of antistreptolysin-O were detected, in 5 (29 %) — high titers of antibodies to Salmonella, in 2 (12 %) cases — IgM to Chlamidia pneumonia, in 2 (12 %) other children — IgM to capsid antigen of EBV, in one case (6 %) — IgM to Mycoplasma pneumonia. Increased erythrocyte sedimentation rate and C-reactive protein level was observed in 15 (88 %) and 12 (70 %) children, respectively. In 12 (70 %) of 17 children, increased level of soluble fibrin-monomer complex was detected in the blood.

   Conclusion. Erythema nodosum in children in most cases is associated with streptococcal infection and salmonellosis. The immune-inflammatory process in erythema nodosum is accompanied with an increase in the level of soluble fibrin-monomer complex in the blood.
Clinico-radiological characteristics of two patients with geroderma osteodysplasticum caused by new nucleotide variants in the GORAB gene
Authors: Merkuryeva E. S. , Markova T. V. , Kenis V. M. , Semyachkina А. N. , Nikolaeva E. А. , Bochenkov S. V. , Kuchina A. S. , Ryzhkova O. P. , Doroshchuk N. A. , Dadali E. L.
Published: March 2024

Geroderma osteodysplasticum (OMIM #231070) is a rare autosomal recessive disorder characterized by congenital wrinkled skin on the dorsal surface of the limbs and abdomen; marked osteoporosis in childhood. Pathogenic variants of the nucleotide sequence in the GORAB gene, which encodes the GORAB protein located in the Golgi apparatus and plays a crucial role in vesicle transport in the Golgi complex, lead to the disease. This is the first report of 2 patients with this disease in Russia. A detailed description of the clinical-radiological and genetic characteristics of these patients with new nucleotide variants in the GORAB gene in a compound heterozygous state is presented: c.170C>G (p.Ser57Ter) and c.790G>C (p.Ala264Pro); c.295C>T (p.Gln99Ter) and heterozygous deletion on chromosome 1 (chr1:g.170531967–170539494del), affecting exons 1 and 2 of the gene. The main clinical manifestations of the syndrome were congenital wrinkled skin, sagging cheeks, hypoplasia of the cheekbones, prognathism, muscle hypotonia and joint hypermobility. Radiological signs included congenital bilateral dislocation of the hip, compression fractures of the vertebral bodies, and disruption of the continuity of the growth plate of the distal femur and proximal tibia, referred to as “insertion.” The rarity of the syndrome, as well as the similarity of clinical manifestations with a heterogeneous group of hereditary diseases accompanied by decreased skin elasticity, leads to a late correct diagnosis. This necessitates the description of the clinical-genetic characteristics of the disease, the study of the dynamics of the formation of its phenotypic manifestations, and the methods of molecular-genetic diagnostics.
The impact of the investment expectation gap on households’ risky financial asset investment
Authors: Xu Xinzhe
Published: March 2024

Rational household asset allocation is crucial for the accumulation of household wealth. However, there is still a widespread phenomenon of limited participation among households. This paper aims to explore the impact of the investment expectation gap on households’ risky financial asset investment. Utilizing data from the China Household Finance Survey 2019, this paper systematically investigates the role of the investment expectation gap in risky financial asset investment through the Probit and Tobit models. The study reveals that the investment expectation gap has a significant negative impact on the investment probability (Average Marginal Effect, –0.118, p < 0.01) and holding proportion (β, –0.082, p < 0.01) of household investment in risky financial assets. This conclusion remains robust after conducting robustness tests by replacing the explanatory variable and performing subsample tests and endogenous treatment. The analysis of transmission mechanisms revealed that an expanding of the investment expectation gap would concurrently result in a decline in households’ assessment of stock’s profitability (Average Marginal Effect, –0.080, p < 0.01), the satisfaction with current asset allocation (β, –0.167, p < 0.05), and the subjective well-being of household members (β, –0.289, p < 0.01). Furthermore, the investment expectation gap not only hampers household investment in risky financial asset, but also diminish the household savings rate (β, –0.055, p < 0.01). This study demonstrates that helping households form reasonable expectations for risky financial assets investment returns will contribute to diversifying household asset allocation and enhancing satisfaction with investment decisions.
AcknowledgmentThis study is funded by the Chongqing Social Science Planning Fund, grant number (2021BS052).
Professores do ensino infantil de Santos - Brasil: O que sabem sobre a saúde bucal?
Authors: Pereira Gelson , Zanin Luciane , Flório Flávia Martão
Published: March 2024

O objetivo deste trabalho foi avaliar o conhecimento em saúde bucal de professores da rede municipal de ensino infantil de Santos/SP. O estudo foi do tipo observacional, transversal, de natureza quantitativa e descritiva. Um questionário contendo questões semi-abertas e fechadas versando sobre o perfil, nível de conhecimento e percepção e também informações sobre a rotina dos educadores em relação tema transversal “saúde bucal” foi aplicado junto aos professores de Santos. Os resultados indicam que, na maioria dos casos, na escola, um adulto é responsável por colocar a pasta de dente na escova da criança (71,9%) e que esta prática é incentivada pela maior parte do corpo docente (60,8%) por acreditarem que a melhor forma de evitar a cárie é por meio do consumo racional de açúcar e de uma higiene bucal regular. Os professores atribuem prioritariamente à família a responsabilidade pela higiene bucal na infância e de forma geral, conhecem as formas adequadas de prevenção às doenças bucais na infância, embora os resultados indiquem que para o uso racional e seguro do flúor na infância são necessárias ações de educação permanente.
As brincadeiras na educação infantil possibilitam a construção da equidade de gênero?
Authors: Borges Thayse Melo , Graupe Mareli Eliane
Published: March 2024

O artigo tem como objetivo conhecer as percepção das professoras sobre o impacto das brincadeiras nas construções de gênero entre as crianças na educação infantil. Os principais referenciais teóricos são: Louro (2014), Felipe (2000, 2003), Auad (2019) e Finco (2003, 2010, 2013). É uma pesquisa com abordagem qualitativa e foram realizadas entrevistas narrativas com seis professoras no período de maio a agosto de 2022 que atuam na educação infantil do município de Lages na rede pública. Os dados foram analisados de acordo com o método de análise de conteúdo qualitativo de Mayring (2002). Os resultados desta pesquisa apontam que há a necessidade de formação sobre gênero e equidade, fazendo-se necessário um aprofundamento sobre a importância do brincar para a construção da equidade de gênero. Em síntese, a preocupação com a manutenção dos papéis tradicionais de gênero apontam que a perspectiva predominante, nesta pesquisa, foi da consolidação das desigualdades de gênero entre homens e mulheres.
Experimental investigation of a novel-designed inclined solar still with bio-wick under dynamic water flow
Authors: Sudalaimuthu Pitchaiah , Sathyamurthy Ravishankar
Published: March 2024

This study experimentally investigates the inclined solar still (ISS) with the incorporation of fins and natural bio-jute cloth under dynamic flow. Experiments are conducted on bright sunny summer days in Coimbatore, Tamil Nadu, India. The newly developed ISS features greatly support passive solar desalination. An increase in mass flow rate (Mf) increases heat transfer meticulously pointing out 0.65, 0.8, and 1 kg/min case absorber, and the water temperature difference is within 3°C. An Mf of 0.285 kg/min is secure for the maximum water temperature reach and clean water yield of 70°C and 4.1 kg/m2, respectively, along with jute cloth, it was 1.6 kg/m2 more against without jute cloth. The presence of a jute cloth cumulative water yield of 2.5 kg/m2 at 0.635 kg/min is very close to the absence of a wick cumulative yield of 2.3 kg/m2 during 0.285 kg/min. From these results, the authors conclude higher Mf is feasible to increase the still performance and clean water yield. The implementation of a fully renewable passive solar still is strongly recommended to attain renewable and sustainable desalination.
Comunicação e pop: uma discussão epistemológica
Authors: Porfírio Costacurta Letícia
Published: March 2024

O presente ensaio pretende trazer uma reflexão sobre a relevância dos estudos sobre o Pop no campo da Comunicação, analisando como ele poderia se encaixar dentro de um possível objeto de estudo. Após o movimento de interdisciplinaridade em pesquisas científicas, o campo comunicacional sofreu com muitas dúvidas em relação aos seus possíveis objetos e o que era de fato estudar a Comunicação. Com esse cenário em mente, a ideia principal é mostrar que existe uma forma de observar a Cultura Pop como um processo comunicacional, sem resumi-la em um produto midiático, considerando toda a sua complexidade, em uma breve revisão bibliográfica.
O ser humano, a educação e a sociedade
Authors: Regert Rodrigo , Haroldo Baade Joel
Published: March 2024

É sabido que o ser humano é multidimensional e, por isso, muito complexo. Não distante disso, a educação, seja básica ou não, necessita compreender melhor essa complexidade, uma vez que se potencializa por meio das pessoas que vivem em sociedade. Nesse sentido, o presente artigo tem como objetivo compreender o ser humano e sua multidimensionalidade nos aspectos educacional e social. Quanto à metodologia, a pesquisa é de natureza básica; utilizou-se do método descritivo; e da forma bibliográfica como procedimento técnico. Concluiu-se que o ser humano, a educação e a sociedade formam uma tríade intrínseca, relacionando-se mutuamente a todo instante e permitindo aos indivíduos um maior conhecimento de si e do mundo à sua volta.
Gênero e desigualdades: limites da democracia no Brasil
Authors: Titara Martins Kamyla Heleny
Published: March 2024

Apresenta a resenha da obra "Gênero e desigualdades: limites da democracia no Brasil", escrito por Flávia Biroli.
Uma reflexão sobre o papel de Judas Iscariotes na poesia de José Saramago
Authors: Conçole Lage Rodrigo
Published: March 2024

O objetivo deste artigo é estudar o modo como o escritor português José Saramago elabora uma releitura da Bíblia. O assunto tem sido muito estudado na sua obra ficcional, mas não em sua produção poética. Consequentemente, visando contribuir para um melhor conhecimento da questão, decidimos examinar de que modo ele trabalhou a figura do apóstolo Judas no poema homônimo. Com essa finalidade, dividimos nosso trabalho em duas partes. Na primeira, apresentamos um breve resumo das informações conhecidas sobre o apóstolo, tal como apresentada nos evangelhos. Na segunda, a partir desses dados, apresentamos uma análise do texto, discutindo suas sobre Deus e sobre o papel de Judas.
Patrimônio negro no sul do Brasil
Authors: Bezerra dos Santos Shyrlene
Published: March 2024

O livro “Patrimônio negro no sul do Brasil” organizado pelas professoras Joana Célia dos Passos e Eliane Debus, ambas professoras da Universidade Federal de Santa Catarina (UFSC) leva-nos a importantes e necessárias reflexões a respeito do legado, da presença e do patrimônio cultural afro-brasileiro na região sul do país. Região esta, historicamente conhecida por super valorar a cultura tradicional hegemônica branca e invisibilizar as que não advêm de origem europeia. Nesse sentido, o livro apresenta através da sua coletânea de 13 textos muito bem selecionados um verdadeiro convite a conhecer outro lugar (es) dessa região chamada sul do Brasil, tradicionalmente conhecida por ser a região mais branca e europeizada do país, e nos remete também a uma grande viagem por essa região desvelando imaginários e construindo outros sentidos, através de suas quase 300 páginas de histórias e registros significativos da presença e contribuição da população africana e afro-brasileira neste lugar. Assim, o encontro com o livro “Patrimônio negro no sul do Brasil” nos traz inúmeras reflexões sobre o legado da população afro-brasileira no sul do Brasil, e sua relevante participação no desenvolvimento econômico, cultural e social neste território.
Desclassificação do conhecimento: reflexão a partir dos estudos da representação
Authors: Gaudêncio Mário
Published: March 2024

Esse trabalho traz como Objetivo refletir sobre uma Representação do Conhecimento baseada na Desclassificação do Conhecimento proposta por Antonio Garcia-Gutierrez. A pesquisa toma como pergunta chave: Por qual motivo o pesquisador deve se debruçar sobre a ideia de uma Desclassificação do Conhecimento? Para responder ao que fora levantado, usa-se como Metodologia uma pesquisa de natureza teórica, bibliográfica e exploratória e tendo como tipologia uma posição qualitativa. A esta investigação, vê-se como Resultado parcial que só é possível pensar sob a ótica e lógica da Desclassificação do Conhecimento caso seja for oportunizada na sociedade uma reconexão cognitiva decolonial. Assim, mostra-se como Conclusão parcial, o fato de ainda se observar a carência de mais pesquisas direcionadas ao processo de Desclassificação Conhecimento, especialmente se pensada como uma possibilidade alternativa de valorização dos saberes humanos.
A feira agroecológica da APROFAM como instrumento de decolonialidade
Authors: Pinheiro de Araújo Joaquim , Matias Guedes Maia Zildenice , Fernandes Santos Christiane
Published: March 2024

A Associação de Produtores e Produtoras Agroecológicos de Mossoró (APROFAM) está, há quase duas décadas, atuando através da produção e comercialização nas feiras agroecológicas. A experiência da feira na Universidade Federal Rural do Semi-Árido (UFERSA) se iniciou em 2019 e foi interrompida em virtude da pandemia da COVID 19. O trabalho em questão apresenta o projeto "Do campo ao campus: Feira Agroecológica da UFERSA" que trata da experiência da feira adentrar nos muros da Universidade. E, tem como objetivo refletir como essa experiência tem possibilitado o desencadeamento de processos decoloniais nas dimensões ambiental, do poder, do saber e do ser. Metodologia: A pesquisa apresenta uma abordagem, predominantemente, qualitativa. Em relação aos instrumentos metodológicos, caracteriza-se como teórica, bibliográfica e empírica. A análise dos resultados será feita mediante o entendimento de colonialidade/decolonialidade explanado por Quijano, Porto-Gonçalves, Maldonado-Torres, dentre outros. Resultados: As feiras agroecológicas possibilitam uma aproximação entre produtores familiares e consumidores de alimentos orgânicos e se constitui como espaço interativo, justo e solidário de oferta de alimentos orgânicos, produzidos pela agricultura familiar local, tornando-a uma novidade e referência quanto à transição agroecológica, produção e consumo alimentar. É uma experiência que promove a autonomia dos agricultores quanto à produção e comercialização. Conclusão: A Feira Agroecológica mobiliza processos decoloniais que se assentam nas dimensões ambiental (produção orgânica), do poder (autonomia), do ser (valorização do ser agricultor) e do saber (valorização do saber da experiência). Além do mais, tem motivado docentes e discentes da UFERSA percebê-la como instrumento pedagógico de ensino, pesquisa e extensão em torno das temáticas de consumo e produção sustentáveis e aproximações campo e cidade, conhecimento científico e conhecimento empírico.
The Effect of Contrast-enhanced Ultrasound via Vessels and Surgical Drains
Guidance Percutaneous Catheter Drainage in the Treatment of Pyogenic Liver
Abscess
Authors: Ming Yuan , Wei Hongmei , Zhang Yulin , Gao Guoqiang , Deng Bo , Huang Li , Wang Qiuping , Zheng Xiaodan , Luo Xue
Published: March 2024

Background::

Pyogenic liver abscess (PLA) is a purulent disease caused by microbial contamination of liver parenchyma and includes amoebic liver abscess,
fungal liver abscess, and the most common bacterial liver abscess.

Objective::

Explore the efficacy of contrast-enhanced ultrasound (CEUS) via vessels and surgical drain guidance percutaneous catheter drainage (PCD) in the
treatment of pyogenic liver abscesses (PLA).

Materials and Methods::

A total of 86 PLA patients who underwent PCD treatment in our hospital from May 2018 to February 2023 were retrospectively selected. Of them,
41 patients were treated under intravenous CEUS guidance (Control group), and 45 patients were treated under CEUS via vessels and surgical
drain guidance (study group). Perioperative characteristics, treatment effectiveness, and incidence of complications were analyzed and compared
between groups.

Results and Discussion::

The duration of surgery, drainage, white blood cell recovery, body temperature recovery, and hospitalization in the study group were longer than
those in the control group (P<0.05). The total effective rate of the study group (95.56%) was higher than that of the control group (80.49%)
(P<0.05). The incidence of complications in the study group (4.44%) was lower than that in the control group (19.51%) (P<0.05).

Conclusion::

Compared with intravenous CEUS alone, treatment under CEUS via vessels and surgical drains-guided PCD was associated with shorter surgical
time, faster recovery, better treatment effect, lower risk of complications, and ensured treatment safety in PLA patients.
Pengaruh Waktu Tanam dan Varietas Cabai Besar pada Tumpang Sari dengan Bawang Merah
Authors: Anisah Anisah
Published: March 2024

Sistem tanam tumpang sari bawang merah dan cabai besar merupakan salah satu teknologi alternatif yang dapat dikembangkan. Bawang merah ditumpangsarikan dengan cabai besar untuk pengoptimalan lahan dan pemanfaatan ruang tumbuh. Sehingga pada saat panen, petani dapat memperoleh hasil yang menguntungkan dibandingkan penanaman secara monokultur. Penelitian dilaksanakan pada bulan September–Desember 2021 di Desa Tlonto Raja, Kecamatan Pasean, Kabupaten Pamekasan. Penelitian menggunakan Rancangan Acak Kelompok (RAK), dengan perlakuan monokultur bawang merah (P0), monokultur cabai besar varietas Gada MK (P1), monokultur cabai besar varietas Baja MC F1 (P2), cabai besar varietas Gada MK dan bawang merah ditanam secara bersamaan (P3), cabai besar varietas Gada MK ditanam 15 HST setelah bawang merah (P4), cabai besar varietas Gada MK yang ditanam 30 HST setelah bawang merah (P5), cabai besar varietas Baja MC F1 dan bawang merah ditanam secara bersamaan (P6), cabai besar varietas Baja MC F1 ditanam 15 HST setelah bawang merah (P7), cabai besar varietas Baja MC F1 ditanam 30 HST setelah bawang merah (P8) dengan 4 ulangan. Hasil penelitian menunjukkan bahwa cabai besar varietas Baja MC F1 yang ditanam 30 HST setelah bawang merah menghasilkan jumlah umbi, bobot basah dan bobot kering bawang merah tertinggi dibandingkan perlakuan lainnya.
Diagnosis and Treatment of Chronic Urticaria: The Importance of Autoimmune Aspects and Comorbidity
Authors: Cherniuk Nataliia , Popadynets Irena , Stoika Ivan , Derkach Marianna , Smachylo Halyna
Published: March 2024

The study aimed to conduct a comprehensive systematic review of the literature on the autoimmune mechanisms associated with chronic spontaneous urticaria (CSU) in adults, explore the association between chronic urticaria (CU) and autoimmune disorders, analyze two case reports, and develop a diagnostic algorithm considering the autoimmune pathogenesis.

Materials and Methods. The literature review was conducted to study the mechanisms underlying autoimmune CU. Two case reports were analyzed and a diagnostic algorithm for patients suspected of autoimmune urticaria was formulated.

Results. CU significantly impairs patients’ quality of life, posing problems in daily activities and is often associated with concomitant autoimmune diseases. Though the pathogenesis of CSU remains incompletely understood, in recent years, there has been significant progress in understanding the pathophysiology of this condition, prompting researchers to explore new agents, especially biological ones, in cases with severe refractory urticaria. We have developed a diagnostic algorithm aimed at improving the management tactics for CSU and autoimmune pathology, that involves a thorough collection of complaints, medical history, performing a series of basic laboratory tests for specific markers of autoimmune disorders, and expanding their spectrum with detailed differential diagnostics.

Conclusions. CU is an important medical and social issue that requires an interdisciplinary personalized approach to patients. The diagnosis of the condition involves a comprehensive approach, considering potential concomitant autoimmune disorders and detailed laboratory investigations, especially in cases refractory to standard second-generation antihistamine therapy. The treatment of CU, specifically the stepwise therapy protocol based on symptom severity and response to treatment and aimed at reducing symptoms, improving patients’ quality of life, and achieving CU remission, is outlined in various national and international guidelines, and is carried out gradually, involving three lines of therapy.
XIII Asamblea general de miembros activos :informe anual 2013
Authors:   Corporación Colombiana de Investigación Agropecuaria - AGROSAVIA
Published: March 2024

2013 marcó un tercer año consecutivo de recuperación de Corpoica. Cumplimos 20 años desde que nuestros fundadores del sector público y privado acordaron un modelo institucional para la ciencia, la tecnología y la transferencia de conocimientos al sector agropecuario. 20 años difíciles en los que a todos nos tomó más tiempo de la cuenta asimilar el nuevo modelo, generar confianza y apostarle decididamente a una Corpoica fuerte que pueda fungir como Motor, Actor y Soporte de un sistema nacional de ciencia y tecnología para el sector agropecuario, en un país con serias falencias de conocimiento acorde a las necesidades de dicho sector. El informe que hoy presentamos a nuestra Asamblea da cuenta de grandes logros y avances de nuestra Corporación durante 2013 y le permite a nuestros miembros y a la sociedad en general conocer en detalle nuestro quehacer institucional
Biblioteca Agropecuaria de Colombia
Authors:   Corporación Colombiana de Investigación Agropecuaria - AGROSAVIA,   Instituto Colombiano Agropecuario - ICA
Published: March 2024

La BAC se orienta a facilitar el acceso y disponibilidad de la documentación agropecuaria producida a nivel institucional, nacional e internacional mediante su captación, procesamiento, análisis y difusión, de acuerdo con las necesidades documentales de investigadores, académicos, formuladores de política, planificadores. productores, agroindustriales, estudiantes y demás público relacionado con el sector agropecuario
Calidad de la canal y de la carne de bovinos sometidos a dos planes de manejo alimenticios :suplementado con torta de palmiste vs. no suplementado
Authors: Aguayo Ulloa Lorena , Santana Martha , Mestra Lorena , Burgos William , Florez Hernando
Published: March 2024

El manejo alimenticio de los sistemas de producción de carne bovina en países de América Latina y el Caribe, están enfocándose en la búsqueda y diversificación de subproductos del agro como fuentes alimenticias de mejor calidad y valor agregado. El objetivo de este trabajo fue evaluar el efecto de una dieta a base de pastoreo más suplemento de torta de palmiste y salvado de arroz, sobre la calidad de la canal y la carne de bovinos del tipo cebú
Microbial Diversity and Functional Profiles of Three Commercial Biofertilizers and Impacts on the Bacterial Communities of Avocado’s Soil Rhizosphere
Authors: Renganathan Prabhaharan , Andrade-Bustamante Gabriela , Martínez-Ruíz Francisco E. , Rueda Puente Edgar Omar
Published: March 2024

Chilean avocado (Persea americana Mill.) exports have accounted for 60 % of the total production and are recognized for their high quality worldwide. However, avocado production has significantly decreased in recent years, which is mainly attributed to abiotic and biotic factors, among which are high and low temperatures, intense and sudden rains, unavailability of water resources, and agricultural salinity. Secondary factors include pests and diseases. Applying plant growth promoting microorganisms (PGPM)-based commercial biofertilizers is a potential practice to increase avocado production and resistance to edaphoclimatic factors. In this study, to determine the functionality of microbial communities present in three commercial biofertilizers (Biofert A, Biofert B, and Biofert C) and thus offer a structure of associated microbial communities, the rhizospheric soil of avocado was analysed using the Biolog EcoPlate™ technique, providing information on the community level physiologic profiles (CLPP) and biodiversity indices by denaturing gradient gel electrophoresis (DGGE). The findings revealed that the microbial diversity in the three commercial biofertilizers is highly different, showing a SIMPER overall dissimilarity of 83.9 % in the catabolic capacity. Concerning the impact on avocados’ rhizosphere soil bacterial communities, the results demonstrated significant changes in their composition, particularly with Biofert A and C. In contrast, Biofert B did not show significant changes, especially on days 15 and 30. Long-term studies are recommended to develop sustainable agricultural practices for Chilean avocados.
Incidence of Vibrio parahaemolyticus Coryphaena Hippurus (dorado fish) and Thunnus alalunga (albacore fish) sold in high-demand markets in Guayaquil City
Authors: Hidalgo Aura , León Melissa , Salazar Llorente Enrique , Maridueña- Zavala María Gabriela , Cevallos Cevallos Juan
Published: March 2024

Foodborne diseases affect around 600 million people in the world. In Ecuador, the Ministry of Public Health (MSP) reported 12,203 cases of food poisoning caused mainly by Salmonella species, hepatitis virus or other pathogenic microorganisms in 2019. However, there are no reports of diseases caused by Vibrio species in Ecuador. The present study assessed the presence of V. parahaemolyticus, mesophilic aerobics, total coliforms and E. coli. Samples of Coryphaena hippurus (dorado fish) and Thunnus alalunga (albacore fish) in 3 different markets in the city of Guayaquil, Ecuador. As a result, Vibrio parahaemolyticus was not found in any of the 60 samples analyzed. In contrast, the E. coli levels met the requirements established in the INEN 183 - 2013 Standard norm. All samples from Market 1 were within the acceptance range regarding mesophilic aerobic levels. However, high mesophilic aerobic levels were obtained in 60% of the albacore samples and 50% of the dorado samples from this market. In the same way, 40% of the albacore and 100% of Dorado samples from market 3 were high in mesophilic microorganisms. However, the mesophilic aerobic analyses revealed safer levels in samples from market 1 than in markets 2 and 3, according to the NTE INEN. 183:2013.
Keywords: Foodborne diseases1, fish2, Albacore3, E coli4, mesophilic aerobics5, Dorado6.
Letter of Editor-in-Chief
Authors: Authors No
Published: March 2024

No abstract
Driving Alertness System Using Deep Learning
Authors: Vaidya Prof. R. S.
Published: March 2024

Abstract: Driver fatigue, a major contributor to road accidents, poses a significant challenge to road safety. Numerous fatal collisions could be prevented by promptly alerting drivers experiencing drowsiness. Several drowsiness detection methods have been developed to monitor driver alertness while driving and issue warnings when attention lapses. These systems employ various techniques to assess drowsiness levels, including extracting key features from facial expressions such as yawning, eye closure, and head movements. Evaluating both the driver's physiological state and vehicle behavior is crucial for identifying signs of drowsiness. This research delves into a comprehensive evaluation of prevalent classification methodologies and a thorough examination of contemporary driver drowsiness detection technologies. The study initially categorizes existing techniques into three broad groups: physiological, vehicular, and behavioral parameter-based approaches. It then provides an extensive review of recognized supervised learning algorithms employed for drowsiness detection. Furthermore, the examination conducts a comparative analysis of the advantages and limitations of various methods.
KEYAKINAN DIRI DENGAN KECEMASAN DALAM MENGHADAPI PERTANDINGAN PADA ATLIT BELADIRI TAE KWON DO
Authors: Mutmainna Mutmainna
Published: March 2024

Kecemasan menghadapi pertandingan merupakan reaksi emosi negatif pada atlit terhadap keadaan tegang dalam menilai situasi pertandingan yang ditandai dengan perasaan khawatir, was-was sehingga menyebabkan atlit merasa tidak berdaya. Penelitian ini bertujuan untuk mengetahui hubungan antara keyakinan diri dengan kecemasan dalam bertanding pada atlit beladiri tae kwon do. Subjek penelitian ini adalah atlit yang berusia 18-24. Penelitian ini menggunakan skala keyakinan diri dan State Trait Anxiety Inventory (STAI). Teknik analisis yang digunakan adalah analisis korelasi product moment. Hasil penelitian ini menunjukkan adanya hubungan negatif yang signifikan (r = -0.570; sig = 0.000 < 0.01) antara tingkat keyakinan diri dengan kecemasan dalam bertanding pada atlit beladiri tae kwon do. Semakin tinggi tingkat keyakinan diri pada atlit beladiri tae kwon do, maka semakin rendah tingat kecemasan yang dimiliki. Sebaliknya, semakin rendah tingkat keyakinan diri pada atlit, maka semakin tinggi pula tingkat kecemasan yang dialami.Kata kunci: Keyakinan diri, kecemasan bertanding, atlit tae kwon doAthletes often find themselves feeling negatively when they are facing a match with their big rivals. This negative emotion commonly characterized by worry and apprehensiveness that probably lead to the feeling of helpless. Thus, this study aimed tofind any correlation between self-confidence and anxiety when Tae Kwon Do athletes face a match. The subjects of the study were athletes aged 18-24 years. This study employed Self-Confidence scale and State Trait Anxiety Inventory (STAI). The data were analyzed using product moment correlation. Further, the results showed that there was a significant negative correlation between self-confidence and anxiety among Taekwondo athletes (r = -0.570; sig = 0.000 < 0.01). The higher the athletes’ self-confidence level, the lower the level of their anxiety. Keywords: Self-confidence, competitive anxiety, athlete tae kwon do
STUDI PENGASUHAN ORANGTUA PADA ANAK AUTIS
Authors: Mufadhilah Mufadhilah
Published: March 2024

Peran orangtua dalam mengasuh anak sangat penting, terutama bagi anak yang mengalami gangguan perkembangan seperti autis. Anak yang mengalami gangguan autis sulit untuk berkomunikasi dan bersosialisasi. Penelitian ini bertujuan untuk mengetahui pengasuhan orangtua pada anak autis yang melibatkan 20 pasang orangtua. Metode pada penelitian ini menggunakan metode kuantitatif deskriptif  dimana pengambilan data menggunakan angket. Hasil penelitian menunjukkan bahwa 75% orangtua menerapkan pola pengasuhan demokratis, kemudian 15% menerapkan pola pengasuhan otoriter, dan 10% orangtua menerapkan pola pengasuhan permisif. Adapun dampak yang dapat dikemukakan pada penelitian ini adalah pada pola asuh demokratis orangtua lebih memahami keinginan dan minat anak. Sehingga perlakuan orangtua didasarkan pada kepentingan anak bukan hanya kepentingan orangtua. Pada pola asuh demokratis menunjukkan bahwa anak lebih mudah diajak berkomunikasi, emosional anak lebih stabil dan tenang. Kemudian pada pola asuh otoriter orangtua lebih mementingkan keinginan dan kepentingannya tanpa memikirkan kepentingan anak, sehingga anak pada pola asuh ini menjadi lebih pendiam dan kurang bisa mengeksplor kemampuannya dalam hal komunikasi dan sosialisasinya. Sedangkan pada pola asuh permisif, orangtua cenderung mengabaikan kepentingan dan keinginan anak dan cenderung menyerahkannya kepada orang lain. Anak pada pola asuh ini cenderung menunjukkan perilaku agresif.Katakunci: Pengasuhan orangtua, autisThe role of parents in raising children is very important, especially for children with developmental disorders such as autism. Where children with autistic disorder is difficult to communicate and socialize. This study aims to determine the parenting autistic children involving 20 sets of parents. Method in this study uses descriptive quantitative method in which data collection using questionnaires. The results showed that 75% of parents applying democratic parenting, then 15% applying authoritarian parenting, and 10% of parents applying permissive parenting. As for the impact that could be addressed in this study is that the children in the democratic parenting parents better understand the desires and interests of children. So that treatment is based on parental interest is not only the interests of the child parents. Later on authoritarian parenting parents more concerned with the wishes and interests without considering the interests and wishes of children. While the permissive parenting, parents tend to ignore the interests and wishes of children and hand them over to someone else.Keywords: Parenting, autism
KEPUASAN KERJA TERHADAP KUALITAS LAYANAN SOPIR JIP DI KAWASAN TAMAN NASIONAL BROMO TENGGER SEMERU
Authors: Maulana Reyza Dwifenda
Published: March 2024

Penelitian ini adalah usaha untuk melihat bagaimana efek dari kepuasan kerja terhadap kualitas layanan pada sopir jip di kawasan Taman Nasional Bromo Tengger Semeru. Desain yang digunakan adalah desain penelitian kuantitatif. Jumlah subjek 146 sopir jip di kawasan Taman Nasional Bromo Tengger Semeru dengan menggunakan teknik purposive sampling. Instrumen  pengumpulan data menggunakan kuesioner dalam bentuk skala Likert. Penelitian ini menggunakan metode analisa data korelasi product moment. Hasil penelitian menunjukkan terdapat hubungan antara kepuasan kerja dan kualitas pelayanan dengan nilai koefisien korelasi (r = 0,155 ; p = 0,062) dengan sumbangan nilai efektif sebesar 2,4 % Hal ini berarti dapat disimpulkan bahwa hubungannya tidak signifikan.    Kata kunci : Kepuasan kerja, kualitas layanan, sopir jip   This research is an attempt to see how the effects of job satisfaction on service quality on jeep driver in the region Bromo Tengger Semeru National Park. The design used was a quantitative research design. Number of subjects 146 jeep driver in the region Bromo Tengger Semeru National Park using purposive sampling technique. Instrument data collection using a questionnaire in the form of Likert scale. This study uses data analysis product moment correlation. The results show there is a relationship between job satisfaction and quality of service to the value of the correlation coefficient (r = 0.155, p = 0.062) with the contribution of the effective value of 2.4%. This means it can be concluded that the relationship was not significant. Keywords : Service quality, job satisfaction,  jeep driver
Formation of schoolchildren’ divergent thinking in the conditions of additional education when working with timelines
Authors: Gerasimova Elena K. , Nimatulaev Magomedkhan M. , Novoselova Svetlana Yu. , Shishkov Mikhail S.
Published: March 2024

Problem statement . One of the most important tasks that digital school teachers face is preparing a graduate, who is ready to use the acquired knowledge in his future life and find non-standard, original solutions, overcoming the usual patterns and established opinions. The study aimed at substantiating the effectiveness of the use of timeline services for the development of divergent thinking in schoolchildren in the conditions of additional education. Methodology . Theoretical and methodological analysis and generalization of fundamental scientific works on the research problem, processing of test results and timelines were applied. The pedagogical experiment involved 130 students of the state budgetary educational institution of Moscow “School No. 1506”. To diagnose and assess the formation of divergent thinking, the method of F. Williams (adapted by E.E. Tunik) was used. Pearson's chi-square test was used as a statistical processing method. Results . The timeline in additional education was carried out when displaying historical facts in chronological order, compiling algorithms, creating biographies, and presenting statistics. The didactic potential of the timeline as a kind of quantitative infographics is revealed, which offers a graphical implementation of digital data in relation to each component in the structure of creativity: flexibility, originality, elaboration, fluency. Statistically significant differences in qualitative changes in the pedagogical system were determined. Conclusion . The use of timeline services in the conditions of additional education contributes to the development of divergent thinking of students due to the possibilities of interactive presentation of events and facts, reuse, multimedia, technical minimalism. Difficulties that complicate the use of virtual timelines are noted: time resource management, the need to develop criteria and indicators for the effective use of web services for the corresponding purpose.