bluuebunny/crossref_metadata_2025 huggingface dataset:
The Monotonic Rising and Oscillating of Capillary Driven Flow in Circular Cylindrical Tubes
Authors: Sun Bohua
Published: July 2020

Among the best-known capillarity phenomena is a capillary rise, the understanding of which is essential in fluidics. Some capillary flows rise monotonically whereas others oscillate, but until now no criteria have been formulated for this scenario. In this paper, the Levine's capillary rise modelling is computed numerically, then the critical radius of the capillary tube is formulated by using the dimensional method and data fitting for identification of exponent index. The phase space diagram of capillary velocity versus height is obtained for the first time and shows that the phase transition from oscillating to monotonic rising happens when the phase trajectory decreases exponentially to somewhere other than the "attractor." Two general Maple codes of the problem are provided as an essential part of this paper.
Microarray Analysis Reveals a Potential Role of lncRNA Expression in remote ischemic preconditioning in Myocardial ischemia-reperfusion injury
Authors: Lou Zhiling , Wu Weijia , Chen Ruiheng , Xia Jie , Shi Haochun , Ge Hanwei , Xue Jiyang , Wang Hanlei , Lin Zhiyong , Chu Maoping , Zhao Qifeng
Published: July 2020

Background

Avoiding or reducing cardiopulmonary bypass-related injuries of important organs is the eternal topic in the field of cardiovascular surgery. Remote ischemic preconditioning (RIPC) is a promising strategy whose clinical application seems more realistic and extensive compared with other conservative or surgical strategies. However, considering its complex process which involves the expression of a variety of molecules and even genes and little is known about its underlying mechanism after years of researches, new train of thought and method must be developed to explore its potential in clinical application. Long noncoding RNA (LncRNA) is a kind of RNA that has been proven be exert efficacy in the occurrence and development of cardiovascular disease. The differential expression of LncRNAs and their biological effects during RIPC have not been reported.
Methods

We first verified the protective effect of RIPC on myocardial ischemia-reperfusionby western blot, ELISA and hematoxylin-eosin(HE) staining. Mouse and human LncRNA arrays were used to investigate the expression signatures of LncRNAs and mRNAs in myocardial tissue after RIPC. Homology comparison was used to screen homologous genes in total differentially expressed LncRNAs. Competing endogenous RNA(ceRNA) mechanism analysis helped us find the matching relationship among homologous LncRNA, mRNA and microRNA.
Results

554 differentially expresssed mouse LncRNAs(281 up-regulated / 273 down-regulated) and 1392 differentially expresssed human LncRNAs(635 up-regulated / 757 down-regulated) were selected from LncRNA microarrays. Quantitative real-time polymerase chain reaction(qRT-PCR) was used to verify these selected LncRNAs, after homology comparison and ceRNA mechanism analysis, we got a pair of homologous LncRNAs(ENST00000574727 & ENSMUST00000123752), predicted corresponding matching relationship and potential competitive binding sites.
Conclusions

In this study, we identify a number of differentially expressed LncRNAs, which may be closely related to the regulation of inflammation and cell proliferation. In addition, we take several pairs of homologous LncRNAs as the next research object. By continuously exploring the function and mechanism of these LncRNAs, we hope to unveil the mystery of RIPC and discover a new protective mechanism of cardiovascular ischemia-reperfusion disease.
Lung Function in a Cohort of Italian Children Born Preterm
Authors: Fainardi Valentina , bonacini ilaria , sapienza eleonora , corradi mara , magnani cinzia , chetta alfredo , pisi giovanna
Published: July 2020

Background and aim: in children born preterm lung development may be affected with impairment of lung function in later ages. The aim of the study was assessing lung function in a cohort of school-aged children born preterm and assess the influence of perinatal variables. Methods: we measured lung function with impulse oscillometry system (IOS) and spirometry in 54 children [(male 48.1%, mean age 8.1 (0.8)] born preterm [mean birth weight (BW) 1462 (546.9) g, mean gestational age 31.5 (3) weeks] at Parma Children University Hospital (Italy). Maternal and perinatal data and respiratory medical history were also collected.Results: compared to predicted values, children born preterm showed higher mean values of airway impedance Z, airway resistance R5, R20, R5-20, area under the reactance curve AX and resonance frequency Fres, lower mean values of reactance X5 and FEF25-75. The mean difference between observed and predicted values of R5-R20 was higher in children born small for gestational age than in those born appropriate for gestational age. An inverse relationship was found between BW z-score and Z (r -0.40, r2 0.16; p 0.012) and R5 (r -0.44, r2 0.20; p 0.005) in children born with a BW <1500 g. Thirty-one per cent of children had a history of wheezing and 14.8% a history of lower respiratory infection requiring admission to the hospital.Conclusions: school-aged children born preterm had an impaired lung function, especially in the peripheral airways, as resulted by IOS and spirometry assessment. BW may have a role in lung development.
The Advantages of Active Breathing Coordinator Device During Left-Sided Breast Cancer Radiation Therapy: A Dosimetric Comparison Study
Authors: Pasinetti Nadia , Bardoscia Lilia , Spiazzi Luigi , Ghedi Barbara , Pedretti Sara , Pegurri Ludovica , Maddalo Marta , Costa Loredana , Buglione Michela , Triggiani Luca , Borghetti Paolo , Figlia Vanessa , Cuccia Francesco , Alongi Filippo , Magrini Stefano Maria
Published: July 2020

Background: Radiotherapy (RT) improves local control and survival in breast cancer (BC) patients. However, risk of heart and lung side effects after post-operative left breast RT for breast cancer remain despite technological and technical RT advances. In a retrospective cohort we investigated if Active Breathing Coordinator (ABC) device can reduce risk of cardiopulmonary morbidity.Methods: we performed two different dosimetric analyses by Normal Tissue Complication Probability (NTCP) and Bio-Dose-Volume Histograms (Bio-DVH) in order to determine whether left breast RT using moderating deep inspiration breath-hold (mDIBH) with the Active Breathing Coordinator (ABC) device, may significantly reduce heart, left anterior descending coronary artery (LADCA) and lung radiation exposure during left breast RT performed with 3d-CRT technique.Results: Several dosimetric parameters were used in the present study to compare the treatment plans generated by FB and mDIBH images of sixty-nine consecutive patients treated between May 2012 and April 2016 at the Istituto del Radio Radiation Oncology Dept. All data derived by Bio-DVH and the heart NTCP calculation showed that ABC led to significant sparing of organs at risk compared with FB, expecially for the heart and LADCA. We also showed that the mDIBH technique significantly reduced left lung dose: in fact, through inflation, only low density lung tissue remains within the tangential field, thus avoiding its deterioration.Conclusions: Use of mDIBH gives a real advantage on breast cancer RT by reducing the radiation to the organs at risk (OARs) and consequently, the risk of cardiac and pulmonary late side effects.
Sustained Low Incidence Rates of Central Line-associated Blood Stream Infections in Intensive Care Unit
Authors: Mazi Waleed Abdulmotalib , Saeed Amir M. , Abdulwahab Mohammed H. , Ashqar Mahmood A. Al , Aldecoa Yvonne S. , Bahat Zaheda R. , Suaking Jennifer L. , Yassin Osama S.
Published: July 2020

The health care associated infections (HAIs) have become a global health problem and need to establish effective infection prevention and control strategies. HAIs increase mortality, length of hospital stay, cost of care, bacterial resistance, antibiotic use and other adverse in intensive care units (ICUs), particularly in developing countries (1, 2). The International Nosocomial Infection Control Consortium showed that the incidence rate for central line-associated bloodstream infection (CLABSI) in ICUs in developing countries was 3-fold higher than the United States (3). It has been proved that implementation on CLABSI bundle prevention can significantly reduce HAIs (4-7).
Assessment of the contribution of assisted reproduction methods for the future development of the number of live births in Czechia
Authors: Burcin Boris , Pachlová Tereza , Šťastná Anna , Kocourková Jiřina
Published: July 2020

Background: The key demographic trend concerns the postponement of parenthood to later ages. Moreover, the number of Czech women of reproductive age is decreasing, which will lead to a decrease in the number of live births even with higher fertility. The aims are to assess recent trends concerning using ART in Czechia and to estimate the impact of using ART on the future development of the number of live births. Methods: Based on data on the number of ART cycles involving the transfer of embryos in the period 2007–2012, the number of deliveries following ART was converted to the number of live births following ART by the maternal age at birth for the period 2008-2012. Subsequently, age-specific fertility rates following ART and models of the potential future development of live births following ART treatment were calculated. These models were based on a combination of two potential fertility development variants and four variants for the estimation of the future share of ART fertility of total fertility by age (V1-V4). Results: If the use of ART methods remains unchanged, there will be a decrease in the number of live births following ART in the period up to 2030 (V1 and V2) due to the declining reproductive potential of women. An increase in the number of live births following ART would occur only if there were an increase in the use of ART methods. Depending on the expected level of the increase in the use of ART, the number of live births following ART would increase by 2030 to 4.9 thousand (V3) and 6.5 thousand (V4). In relative terms, this would represent an increase from the initial 3.2% of the total number of live births to 5.0% and 6.8% respectively. Conslusions : We can expect an increase in the importance of ART for demographic trends in the future. The projection models assumed that the future development of the use of ART would be affected not only by the intensity of fertility postponement and different levels of fertility, but also by advances in reproductive medicine and the increasing availability of ART.
Quick Delivery of Aldehyde Dehydrogenase into Yeast Vacuoles by QRPL Peptide Sequence on Carboxypeptidase Y
Authors: Park Dong Jun , Nguyen Ngoc-Tu , Kim Ji Hun , Nguyen Ngoc-Han , Kim Sunchang , Cho Byung-Kwan , Kim Yang-Hoon , Min Jiho
Published: July 2020

Background

The signal peptide sequence is known to increase transport efficiency to organelles in eukaryotic cells. In this study, we focus on the signal peptide of the vacuolar protein for vacuolar targeting.

Results

The signal peptide sequence QRPL of carboxypeptidase Y (CPY), a vacuolar protein, was inserted inside the green fluorescent protein (GFP) that does not locate in vacuole for vacuolar targeting. The protein location was then confirmed by confocal microscopy. Fascinatingly, the green fluorescent protein that contains QRPL inside the sequence could be expressed faster than its natural form (within 1 hour after induction). In addition, aldehyde dehydrogenase 6 (ALD6), a cytosolic protein has engineered the sequence with QRPL to be transported to the vacuole. The aldehyde removal activity of ALD6 protein in the recombinant yeast was then analyzed by measuring the luminescent intensity in Vibrio fischeri .

Conclusions

In summary, the signal peptide QRPL could be used not only to transport target proteins accurately to vacuole but also to improve the protein activity, as well as to shorten the induction time.
Desain Turunan Kalkon Baru Sebagai Antikanker Payudara Berdasarkan Molecular Docking
Authors: Karlina Lilis , Hafshah Mutista
Published: July 2020

Penelitian ini dilakukan untuk menentukan senyawa turunan kalkon yang berpotensi sebagai antikanker payudara berdasarkan Molecular Docking. Protein yang digunakan yaitu 17β-hidroksisteroid dehydrogenase. Adapun ligan yang digunakan adalah 20 senyawa turunan kalkon yang dibandingkan dengan senyawa obat pembanding. Posisi pusat grid pada sisi aktif protein kanker payudara yang telah dilakukan pada penelitian sebelumnya yaitu pada leusin 149.X CB, serin 142.X OG, dan asparagine 152.X OD1. Software yang digunakan yaitu hyperchem, Gaussian03, Molden, Autodock Tools, Autodock4, dan chimera 1.5.3. Penelitian ini dilakukan dengan empat langkah yaitu pencarian kompleks protein-ligan 17β-hidroksisteroid dehydrogenase dengan kode PDB 3HB4, optimasi struktur ligan dengan metode perhitungan AM1, molecular docking, dan pemilihan senyawa turunan kalkon sebagai antikanker payudara. Hasil docking turunan kalkon memiliki akivitas daya hambat terhapat protein 17β-hidroksisteroid dehydrogenase dengan nilai sebesar 4,41 × 10-6M sampai 2,4783 × 10-7M. Hasil molecular docking didapatkan senyawa turunan kalkon sebagai antikanker payudara yaitu kalkon X memiliki tetapan inhibisi 2,4783 × 10-7M.
The Failure of the Stalinist Propagandist: the Trial of Yakov Alperovich, Editor of the Sovetskaya Sibir (1937–1938)
Authors: Papkov S. A.
Published: July 2020

The research featured the biography of Yakov Alperovich, a prominent figure of the Siberian Soviet establishment in the 1920s–1930s. Starting at the social bottom, his career path was a typical example of the dramatic fate that befell most Stalinist officials. The article describes the main steps of his career ladder on the way to political power during the purges of 1937–1938, as well as the changes in the Stalinist politics in the 1930s, which were the ruin of the internal party relations. The author assessed the socio-political atmosphere in the administrative establishment. The study focused on the role of denunciations as a tool against the so-called hostile elements. The dramatic end of Yakov Alperovich, a district committee secretary and an editor, reflects the general tragedy of the Soviet Communists that fell victims to the Stalin's repressions. The article introduces new historical facts and expands the knowledge about Siberia in the Stalin era.
The Concept of " Muzh" (Husband): Motivating Signs
Authors: Kiseleva A. M.
Published: July 2020

This article presents a historical and etymological analysis of the motivating signs of the concept of "muzh" (husband) in the Russian language. Primary signs of the concept make up the internal form of a word and serves as the basis for new cognitive signs. Actual motivating signs appear first as conceptual ones and later as functional, evaluative, symbolic, and figurative. The primary motivating sign is "man": it is the oldest one and goes back to the pre-Indo-European language. The analysis of etymological dictionaries revealed 42 motivating signs. The article provides examples of the representation of this concept in the literature, including the modern one. Etymological and historical-etymological dictionaries revealed the following motivating signs of the concept of "muzh" (husband): a man; a male spouse; an adult man; a man that understands; a scientist; an ancestor; an Amazon female warrior; an age; people; community member; a serious man; a citizen; a brave man; a strong man; a fighter, a warrior; an ordinary man; a hero; a male celebrity; a respected, venerable man; a public figure; a witness; a free man; a peasant, a farmer; a feudal-dependent peasant; a peasant (low status in legal relations); to man oneself; a person with unnaturally large manhood; a male specimen; an attendant of a tsar, king, or prince, a noble man; a servant of a prince, a warrior in the prince’s squad; a divine husband; a man of desire; a blood man, a murderer; big men (a privileged part of the free population in Ancient Russia); young men (a less privileged part of the free population in Ancient Russia); nobleman (a great man); a member of household; a servant; a hand (worker); a slave; someone who is ready. Such a long list of motivating signs confirms the ancient history of the concept and its socio-cultural significance in the Russian linguistic worldview.
YAŞLILARDA PROTON POMPA İNHİBİTÖRÜ KULLANIMI VE RENAL FONKSİYONLARLA İLİŞKİSİ
Authors: ALP Alper , ERSAN Sibel
Published: July 2020

Amaç: Son dönemlerde proton pompa inhibitörlerinin yan etkilerinden ve özellikle de renal etkilerinden daha sık söz edilmektedir. Akut tübülointerstisyel nefrit, akut böbrek hasarı, kronik böbrek hasarının progresyonu gibi klinik durumlara neden olabileceği düşünülmektedir. Biz bu çalışmamızda nefroloji polikliniğimize başvuran yaşlı hastalarda proton pompa inhibitörü kullanım sıklığını, proteinüri ve böbrek hasarıyla olan ilişkisini inceledik. Yöntem: Bir yıllık sürede nefroloji polikliniğine başvuran 75 yaş ve üzerindeki hastaların dosyaları incelenmiştir. Bulgular: 75 yaş ve üzeri nefroloji polikliniğine başvuran hastalarımızda proton pompa inhibitörü kullanma sıklığı yüksektir. Proton pompa inhibitörü kullanan yaşlı hastalarda kronik böbrek hasarı birlikteliği istatistiksel olarak anlamlı olmasa da daha sık bulunmuştur. Tartışma: Proton pompa inhibitörlerinin bilinçsiz ve/veya endikasyon dışı kullanımı renal fonksiyonlarda bozulmayla ilişkili olabilir. Proton pompa inhibitörü kullanmak zorunda olan hastalarda renal fonksiyonlar takip edilmelidir.
Hip Arthroplasty in Patients with Hip Dysplasia by Individual Augments: Early Results
Authors: Rukin Ya. A. , Lychagin A. V. , Murylev V. Yu. , Garkavi A. V. , Tarasov D. A. , Elizarov M. P.
Published: July 2020

Relevance. The altered hip anatomy makes total hip arthroplasty in patients with hip dysplasia a difficult and non-standard task. The acetabulum is deformed with femoral head in subluxation or dislocation. The most important task of surgery is to restore the anatomical position of the hip center of rotation.The study purpose — to evaluate the early results of hip arthroplasty with individual augments in the patients with hip dysplasia.Materials and Methods. Since 2017, nine patients with hip dysplasia have undergone surgery using individually printed augments. All patients were women with average age 51.3±14.5 years (23 to 67). The mean follow-up was 14.3±5.2 months (8 to 20). Patients were evaluated using follow-up X-rays, a visual analogue scale (VAS), Harris Hip Score (HHS), and Western Ontario and McMaster Universities Arthritis Index (WOMAC).Results. There was no a single case of endoprosthesis dislocation, loosening of components, prosthetic infection or revision surgery in the analyzed group of patients. The planned sizes of the acetabular components were equal to the placed in 7 cases (77.8%). In two cases (22.2%), the acetabular components were 2 mm larger because the surgeon wanted a greater degree of press-fit fixation. The restoration of the anatomical position of the acetabular component was noted. Before the surgery, the femoral head was on average 22.7±11.7 mm (10 to 43 mm) higher. After the surgery, the level of the acetabular component was on average only 0.75±2.1 mm (1.7 to 5 mm), p = 0.008. Also, there were a decrease in pain and quality of life improvement by VAS from 6.78±1.39 before surgery to 2.22±1.09 at follow-up (p = 0.007), HHS increase from 30.5±18. 1 to 77.59±14.26 (p = 0.008), and WOMAC decrease from 73.3±14.1 to 18.22±8.2 (p = 0.008).Conclusion. The individually printed augments have shown high efficacy for restoration of the anatomical center of rotation and good early results in the patients with hip dysplasia undergone hip arthroplasty.
A NOVEL VALIDATED UHPLC METHOD FOR ESTIMATION OF ASSAY AND ITS RELATED SUBSTANCES OF TRICHOSTATIN-A
Authors: RAO L. VAIKUNTA , RAO K. TIRUMALA , KANDEPI V. V. KRISHNA MOHAN
Published: July 2020

Objective: The main objective of the research work is to develop and validate a rapid UHPLC method for the estimation of assay and its related substances of Trichostatin A (TSA) in pharmaceutical samples.

Methods: The UHPLC method developed for chromatographic separation between TSA and its related compounds on Poroshell 120 SB C18(50×4.6) mm; 2.7 µm RRLC column using Agilent RRLC (UHPLC) system with linear gradient elution.

Results: The developed UHPLC method has shown excellent chromatographic separation between TSA and its related compounds within 12 min run time, during validation experiments, specificity study revealed that the peak threshold was more than the peak purity and no purity flag was observed. Repeatability, intra, and inter-day precision results were well within the tolerable limits. Limits of detection concentrations were found between 0.075 to 0.077 ppm and the limit of quantitation is between 0.252 to 0.258 ppm for related compounds and TSA. The related substances method recoveries were found between 80 and 120 % and assay method recovery was found between 98.0 to 102.0%.

Conclusion: The developed method capability was proven for the assay of TSA and its related compounds in pharmaceutical samples and the method shows eco-friendlier than routine, conventional HPLC methods in terms of analysis time, cost and HPLC effluent waste.
Cellular automata in operational probabilistic theories
Authors: Perinotti Paolo
Published: July 2020

The theory of cellular automata in operational probabilistic theories is developed. We start introducing the composition of infinitely many elementary systems, and then use this notion to define update rules for such infinite composite systems. The notion of causal influence is introduced, and its relation with the usual property of signalling is discussed. We then introduce homogeneity, namely the property of an update rule to evolve every system in the same way, and prove that systems evolving by a homogeneous rule always correspond to vertices of a Cayley graph. Next, we define the notion of locality for update rules. Cellular automata are then defined as homogeneous and local update rules. Finally, we prove a general version of the wrapping lemma, that connects CA on different Cayley graphs sharing some small-scale structure of neighbourhoods.
EFL LEARNERS' DIFFICULTIES IN THE STRUCTURE AND WRITTEN EXPRESSION SECTION OF TOEFL TEST IN AN INDONESIAN UNIVERSITY
Authors: Akmal Saiful , Rasyid Muhammad Nur Akbar , Masna Yuliar , Soraya Cut Natasha
Published: July 2020

This study examined the English for Foreign Language (EFL) learners' difficult topics in the structure and written expression section of the TOEFL Prediction Test, and reasons why they consider that these topics were difficult. The mixed-method research design was used in this study. Fifteen participants were selected through purposive sampling mechanism from the seventh-semester students of Department of English Language Education, Universitas Islam Negeri Ar-Raniry who have participated in the TOEFL Prediction Test to identify the difficult topics they encountered. Then, the semi-structured interviews were conducted to six underachieving student's participants with the most recorded errors made in the test to know the reasons behind their difficulties. Findings indicated that students encountered difficulties mostly when dealing with determiners, conjunctions, adjective clauses, apposition phrases, and reduced clauses in the structure section. Meanwhile, adverb connectors, subject-verb agreement, and clause of concession, relative clause, and quantifier are the difficulties they encountered in the written expression section of the test. Thus, the findings also revealed several factors identified as the reasons behind those difficulties, namely lack of practice, grammar incompetence, vocabulary shortage, time management, and low self-confidence. Given the significant impact of this study, we suggested that the lectures and English departments should address these difficulties. It is crucial that the focus of the courses related to grammar and EFL proficiency tests be incorporated into the syllabus.
THE ANALYSIS OF FLOUTING MAXIM IN GOOD MORNING AMERICA (GMA) TALKSHOW
Authors: Marlisa Rofa , Hidayat Didin Nuruddin
Published: July 2020

The present study is an analysis of the flouting maxim in Good Morning America (GMA) talk show in which Jackie Chan was invited as the guest star. The goals of this research are to find out the performed flouted maxim(s) by the hosts and the guest and to reveal the reason(s) behind the occurrence of the maxim(s). In this study, the researchers employed the qualitative method, and data were collected from a video. The transcript text of the utterances between the hosts and Jackie Chan as a guest consisting of flouting maxim was the instrument of this research. Then, to find and analyze the flouting maxim showed in the video, the researchers used Grice's (1975) theory Cooperative Principles consisting of four maxim types: quality, quantity, relation, and manner. The result showed that all four types of maxim flouting were committed by both Jackie Chan and the two hosts of the GMA talk show. The highest flouting maxims found were flouting the maxim of quantity and manner. Further, the study also revealed the rationales behind maxims flouting, which were beneficial to build fun communication and to elaborate more explanations.
Análise macroscópica do efeito de diferentes protocolos de nitrogênio líquido sobre a mucosa bucal: estudo em ratos
Authors: Bonfim Santos Aira Maria , Sant'Ana Filho Manoel
Published: July 2020

O presente trabalho propõe uma análise macroscópica do efeito de diferentes protocolos de nitrogênio líquido. Realizou-se a aplicação do nitrogênio líquido com o sistema fechado, a sonda; com o sistema aberto, spray; e, com o sistema aberto, hastes pré-fabricadas com pontas de algodão, em mucosa bucal de ratos, como modelo de estudo. O nitrogênio líquido foi aplicado em dois ciclos de vinte segundos cada, com intervalo de cinco minutos. A morte dos animais foi realizada após seis horas do experimento. Os dados de comprimento e largura da língua, iniciais e finais, foram analisados, nos grupos, e comparados entre si. O grupo spray apresentou a formação de edema intenso e generalizado. Ocorreu variabilidade das alterações evidenciando ser esta técnica de difícil controle. A técnica de aplicação do nitrogênio líquido com a sonda apresentou uma deformação anatômica devido ao edema provocado na língua, sendo este inferior ao edema provocado pelo spray. As alterações provocadas pela aplicação do nitrogênio líquido com hastes de algodão foram mais brandas e restritas à área central de aplicação do agente criogênico. Concluiu-se que a aplicação de nitrogênio líquido com spray não deve ser usado como tratamento de lesões em cavidade bucal. A técnica que utiliza hastes com ponta de algodão é mais recomendada por permitir melhor controle do dano.
Efeito da idade sobre a espessura do cemento dentário
Authors: Vianna Freitas Fachin Elaine , Cristine Klein Lúcia
Published: July 2020

Trata-se de um experimento in vitro com 27 dentes humanos extraídos de diferentes faixas etárias. Esses dentes foram divididos em três grupos (Grupo 1: 20 a 40 anos, Grupo 2: 41 a 60 anos e Grupo 3 : mais de 60 anos). Após, foram seccionados, com cortadora de precisão Labcut 1010, segundo seus longos eixos e os cortes obtidos foram avaliados com o objetivo de comparar a espessura de cemento apical nas diferentes idades. Com o auxílio de um microscópio ótico (ZEISS -modelo Standard 20) associado a um microcomputador (UNISYS-modelo Aquanta DX), verificou-se, em concordância com a literatura, um aumento de espessura do cemento de acordo com a faixa etária.
News and Comment
Authors: Martin Amanda
Published: July 2020

News and Comment
Gri İlişkisel Analiz Yöntemi ile Tufal Katkılı Harçların Basınç Dayanımı ve Porozitesinin Optimizasyonu
Authors: ARICI Erdinç , KELEŞTEMUR Oğuzhan
Published: July 2020

İnşaat sektöründe betonun kalitesinin artırılması amacıyla çimentoya veya beton karışımı içerisine farklı malzemeler katılır. Fakat bu malzemeler bazen betonun bazı özelliklerini iyileştirirken bazı özelliklerini de ters yönde etkileyebilmektedir. Bu ilave malzemelerin beton üzerine olan etkilerinin tam olarak belirlenmesi amacıyla çok sayıda deneye ihtiyaç duyulmaktadır. Bu durum zaman ve malzeme kaybına neden olmaktadır. Bu çalışmada, demir-çelik endüstrisinin atık malzemelerinden biri olan çelik tufalin agrega olarak ilave edilmesi ile elde edilen harç numunelerindeki parametrelerin basınç dayanımı ve porozite üzerine olan etkileri incelendi. Bu parametrelerin optimizasyonu için Gri İlişkisel Analiz (GİA) yöntemi kullanıldı. Deney serilerinin belirlenmesinde dört parametreli L16 ortagonal dizininden faydalanılmıştır. Bu amaçla, farklı seviyelerde ince tufal, iri tufal, su/çimento oranı ve çimento dozajına sahip harç numuneleri hazırlanarak basınç dayanımı ve porozite değerleri elde edildi. Bu veriler Gri İlişkisel Analiz yöntemiyle değerlendirildi. Yapılan analizler sonucunda, optimum seviyeler ve basınç dayanımı ile porozite arasındaki ilişki belirlendi.
THE SURAU SULUK AND TRADITION OF RATIK TOGAK: THE EXPRESSION OF PIETY AMONG THE FOLLOWERS OF THE TAREKAT NAQSABANDIYAH IN ROKAN HULU, RIAU
Authors: Hartono Toni
Published: July 2020

Tulisan ini mengkaji tentang eksistensi Surau Suluk dan tradisi Ratik Togak yang menjadi salah satu amalan pengikut tarekat Naqsabandiyah di Rokan Hulu, Riau. Rokan Hulu dikenal dengan julukan Negeri Seribu Suluk, memiliki sekitar 122 Surau Suluk yang tersebar di seluruh wilayah. Bagi pengikut tarekat, Surau Suluk merupakan wadah untuk menjalani aktivitas keagamaan sebagai jalan mendekatkan diri kepada Allah. Penelitian ini menggunakan metode kualitatif dengan pendekatan fenomenologi untuk melihat tradisi keagamaan para pengikut tarekat Surau Suluk. Hasil penelitian menunjukkan bahwa Surau Suluk di Rokan Hulu eksis dan berkembang melalui peran Syekh Abdul Wahab Rokan dengan ajarannya tarekat Naqsabandiyah. Salah satu amalan yang menjadi tradisi dalam ajaran tarekat Naqsabandiyah adalah Ratik Togak. Ratik bermakna zikir atau ratib merupakan amalan berupa zikir dan istighfar yang dilakukan untuk mencari puncak kenikmatan berzikir. Ratik Togak dilakukan pada event keagamaan tertentu di ruang publik sebagai medium penting bagi mereka untuk mendekatkan diri kepada Allah. Ratik Togak merupakan salah satu bentuk dari ibadah keagamaan Islam yang bersifat sosial. Tradisi ini semakin istimewa karena menjadi ikon bagi Surau Suluk yang melibatkan unsur masyarakat awam dan dukungan dari pemerintah. Tradisi ini merupakan amalan bagi pengikut tarekat Naqsabandiyah sebagai bentuk kesalehan mereka dengan Sang Pencipta.This study examines the existence of Surau Suluk and the tradition of Ratik Togak, which is one of the practices of the Naqsabandiyah tarekat in Rokan Hulu, Riau. Rokan Hulu is known by the nickname ‘Negeri Seribu Suluk’, having approximately 122 Surau Suluk which are spread throughout the region. For followers of the tarekat, Surau Suluk is a place to undergo religious activities as a way to get closer to God. This study uses a qualitative method with a phenomenological approach to see the religious traditions of followers of the Surau Suluk congregation. The results showed that Surau Suluk in Rokan Hulu existed and developed through the role of Sheikh Abdul Wahab Rokan with his teaching of the Naqsabandiyah order. One practice that has become a tradition in the Naqsabandiyah tariqah is Ratik Togak. Ratik means dhikr or ratib is a practice in the form of dhikr and forgiveness which is done to find the peak of enjoyment of dhikr. The Togak Ratik is performed at certain religious events in public spaces as an important medium for them to get closer to God. Ratik Togak is a form of social Islamic religious worship. This tradition is increasingly special because it has become an icon for Surau Suluk which involves ordinary people. It also gets support from local government. This tradition is a practice for followers of the Naqsabandiyah order as a form of their piety with the Creator (God).
Job Satisfaction of Non-Permanent Teachers in South Nias Amid Limitation
Authors: Yohanes Dakhi Timotius Duha,
Published: July 2020

Teachers in South Nias still adhere to their culture and customs. They really hope that they are given the opportunity to get permission to attend indigenous cultural and cultural events as part ofbalancing work and life.Most of the teachers in South Nias only have the status of non-permanent teachers, or volunteers, but they are very proud of being teachers even with a small salary. Participants in this study were 46 junior highpublic school teachers in remote villages. Data were analyzed by Partial Least Square method to test the mediation effect to determine the effect of exogenous constructs with endogenous constructs through mediating variables. The result showed that work life balance had a positive and significant influence on self-esteem and job satisfaction. Self-esteem has a positive and significant influence on job satisfaction. Moreover, the total effect of work life balance on job satisfaction increases after mediated by self-esteem.
Urgency Praktik Pranayama Di Era Milenial
Authors: Pradnyantari Bintang
Published: July 2020

Penulisan karya tulis ini bertujuan untuk memaparkan pentingnya praktik pranayama di era milenial. Adapun yang menjadi latar belakang penulisan ini karena tingkat stres di masyarakat yang semakin hari semakin banyak masyarakat yang mengalami stres dari berbagai kalangan. Ini terjadi dikarenakan pekerjaan, gaya hidup dan juga lingkungan social masyarakat. Pranayama mengajarkan agar bernafas secara sadar yang dapat mengurangi pergolakan emosi, agar kita dapat bernafas lebih seimbang, tenang dan mendalam. Bernafas secara sadar bekerja langsung di pusat integrasi pikiran dan badan. Ingatan adalah gerakan dari pernafasan, dan pernafasan adalah gerakan ingatan. Dengan berbagai permasalahan yang dialami masyarakat saat ini peran pranayama sangatlah penting dalam menyembuhkan penyakit yang banyak dialami oleh masyarakat seperti stress yang mendalam yang diakibatkan oleh permasalahan permasalahan di era modern ini, yang dapat mengganggu pikiran  hingga membuat masyarakat menderita penyakit stres yang juga penyakit stress ini dapat memicu penyakit fisik yang dapat membahayakan tubuh sehingga tidak dapat menjalani aktivitas secara fit. Pranayama memberikan efek positif yang sangat banyak manfaatnya untuk masyarakat di era modern ini. Dengan melakukan pranayama masyarakat dapat mengendalikan nafasnya sehingga dapat juga mengendalikan pikiran dan jika sudah dapat mengendalikan pikiran maka tingkat stress pada masyarakat dapat menurun.
Peran Jnana Marga Dalam Meretas Samsara Menurut Kausitaki Upanisad
Authors: Serliani Ni Wayan
Published: July 2020

Jnana marga adalah suatu jalan menuju moksa dengan mempergunakan ilmu pengetahuan dan kebijaksanaan. Dalam Bhagavad Gita IV.33 dijelaskan bahwa orang yang mempersembahkan ilmu pengetahua, lebih mulia dari pada persembahan materi. Secara keseluruhan, semua kerja berpusat pada ilmu pengetahuan.Sivanada (1993:133-134) menyatakan bahwa jñanayoga merupakan  jalan pengetahuan.Dalam buku  Sri Svami Sivananda juga mengatakan bahwa Samsara adalah kekuatan yang berlangsung terus menerus dalam kehidupan, bahkan dari sudut pandang duniawi begitu banyak mimpi dan begitu banyak ambisi yang dikejar belum terpenuhi, kaum muda perlahan-lahan jatuh kedalam usia tua dan kelemahan, dan bara api harapan yang sulit dipahami semakin pudar dan melemah namun nyalanya tetap berkedip oleh sebuah harapan yang tipis bahwa mungkin dalam kelahiran berikutnya mimpi-mimpi itu mungkin dapat dipenuhi.Pengetahuan membawa kita ketempat dimana nafsu itu berhenti, a-kama, dimana semua keinginan terpenuhi, apta-kama, diman atman sajalah yang menjadi keinginan atma-kama .dia yang mengerti dirinya tidak akan memiliki keinginan. Ketika yang maha tinggi terlihat semua ikatan hati akan terputus, keragu-raguan akan lenyap dan akibat dari perbuatan kita terbasmi. Tidak aka nada penderitaan, kesakitan, atau ketakutan. Jiwa yang terbebas adalah seperti orang buta yang yang memperoleh pengelihatannya, orang sakit yang sempurna. Dia mencapai sukacita yang maha tinggi, yang bila diumpamakan dengan perumpamaan yang dangkal adalah layaknya kebahagian perkawinan. Dia bisa mencapai dunia mana saja yang dia cari. Hukum karma berlaku dalam dunia samsara dimana perbuatan kita akan menuntun kita kedalam tempat yang lebih tinggi atau lebih rendah dalam dunia waktu. Apabila kita memperoleh pengetahuan tentang kenyataan abadi brahmanatau atman perbuatan tidak lagi mempunyai ikatan terhadap kita. Keadaan hidup abadi dikatakan berada diluar kaidah baik buruk.
Monisme: Pengetahuan Yang Membawa Kebijaksanaan
Authors: Brahman I Made Adi
Published: July 2020

Monism is the view of God in unity in everything. Everything is God and the all one in the Lord. One God and covers everything and everything is covered by the Lord. Isn’t theresomething other than God. He is the one visible into the variegated because of the influence of maya. Through knowledge, the wise men would come to the real truth. He who has God (Brahman), will be God itself.
UPAYA PEMANGGILAN PAKSA OLEH BADAN PENYELESAIAN SENGKETA KONSUMEN (BPSK) TERHADAP PELAKU USAHA YANG TIDAK HADIR DALAM PENYELESAIAN SENGKETA KONSUMEN
Authors: Mantili Rai
Published: July 2020

One of the authorities of the Consumer Dispute Settlement Agency (BPSK) is to receive both written and unwritten complaints from consumers regarding the occurrence of violations of consumer protection. Article 52 Sub-Article g of the Consumer Protection Law (UUPK) au- thorizes BPSK to summon business actors who allegedly violate consumer protection. However, in practice in the field, BPSK is not authorized to force involuntary calling of business actors so that many business actors refuse to be present at consumer dispute resolution in BPSK. This research is Normative and Analytical Descriptive Research. In this case, it is a Nor- mative Legal Research in the form of research to find the Law of Concreto, the research to find the law for a case in concreto is an attempt to find out whether the appropriate law to apply in cocreto in order to solve a particular case and see the rule of law is found . This research will illustrate various legal issues and other symptoms related to cases concerning consumer protec- tion and BPSK Implementation of consumer protection law enforcement in practice is not yet fully fea- sible. It can be seen apart from awareness of the ability and independence of consumers to protect themselves against the rights and kewajibanya, also can be seen from law enforcement officers who have not performed optimally. efforts that can be made by BPSK after forced calling of business actors who refuse to attend the consumer dispute resolution can make a verdict verdict if the business actor is not present 3 times on the summons of the session by BPSK as stipulated in Article 52 UUPK and Kemendag. 35/2001.
Komunikasi Simbolik dalam Tari Pendet Lanang pada Usabha Sambah di Desa Pakraman Pesedahan Kecamatan Manggis Kabupaten Karangasem
Authors: Ratna Pramesti Dasih I Gusti Ayu
Published: July 2020

Communication can be done in a simple way to a complex way. The process of communication can be seen from the activities of social life so that the process of symbolic communications of society can be formed based on the meanings that are believed by himself then embodied with the symbols of communication. Dance Pendet Lanang acts as a communicator and village community Pakraman Pesedahan as a communicant. Communication process can occur in one direction or two way. The symbols contained in the Dance Pendet Lanang in the Village Pakraman Pesedahan has a uniqueness because the message conveyed has a sacred value that is believed and needs to be communicated to the public. Pendet Lanang Dance is one of the sacred dances that must be performed during the series of Usabha Sambah in Pakraman Pesedahan Village conducted every Purnama Fifth in accordance with the Balinese calendar system.
O impacto do advento de uma Unidade Básica de Saúde Fluvial na assistência aos povos ribeirinhos do Amazonas
Authors: Reis Marcelo Henrique da Silva , Portugal Jéssica Karoline Alves , Mariño Josiane Montanho , Barros Wendel da Silva , Dantas Jaynne de Souza , Souza Tanny Thaylle Gomes de , Reis Yara da Silva dos , Germano Sibele Naiara Ferreira , Barão Évelyn Janaína da Silva , Freitas Duã Louise Aires de
Published: July 2020

Objetivo: Relatar o impacto que a assistência em uma Unidade Básica de Saúde Fluvial trouxe para a melhoria da assistência às populações ribeirinhas em um município do Amazonas. Relato de experiência: Trata-se de um relato de experiência do tipo descritivo, obtido durante o acompanhamento de toda logística e apresentação de relatórios de uma Unidade Básica de Saúde Fluvialmazonas, entre dezembro de 2017 a fevereiro de 2020. Os resultados que o advento da unidade trouxe para a população contemplam: maior cobertura dos exames citopatológicos das mulheres na faixa etária preconizada entre 25 a 64 anos, maior cobertura vacinal da população que vive mais isolada, garantia de atendimentos odontológicos para quem nunca teve acesso a esse serviço, realização de exames laboratoriais para diagnóstico imediato, além da intensificação dos serviços de prevenção, através de palestras educativas. Considerações finais: Os comunitários que vivem na área ribeirinha do município possuem carências no acesso à saúde, educação, informação, dentre outras necessidades. A estratégia de operacionalização da UBS Fluvial trouxe grandes avanços através da implementação dos programas do Ministério da Saúde, neste sentido, fortalecer e avançar nas ações da zona rural é fundamental para a cobertura destes povos.
The histopathological effect of diclofenac potassium on maternal and fetal tissues
Authors: Abdel-Rahman Tawfik  , Nouf Bader Alduweesh  , Zeinab Abdel-Hameid Mohamed  , Abdel Rahman Sayed Sultan  , Heba Ali Abd El-Rahman
Published: July 2020

Diclofenac (DCF) is one of the most generally utilized non-steroidal antiinflammatory therapies during the world for different diseases curing in post pubertal ladies. Be that as it may, constrained data is accessible with respect to its security during pregnancy and teratogenicity. The present study was done to investigate the histopathological impact of diclofenac potassium (DP) on some vital maternal and fetal tissues, placenta and liver during two different periods of gestation. In this study 30 pregnant rats have been used and divided into 3 groups (ten for each one); group 1 (control), group 2 treated with 15.4 mg/kg of diclofenac potassium during organogenesis period, and group 3 subjected during fetal developmental period with the same dosage. At the 20 gestation day the rats were anesthetized and dissected, histopathological studies on placenta, maternal liver, and fetal liver have been done. Our results revealed moderate to severe histopathological alternations in all examined tissues like disorganization of tissue architecture, vacuolation, lymphatic infiltration, apoptosis and more changes. There is a harmful effect of the DP on the placenta tissue and also the liver tissue of the fetus, and on this we recommend that you use the DP with caution during pregnancy at the possible lowest effective dose and for the shortest duration.
A Prospective Study On The Prevalence Of Retinal Lesions Among The Hypertensive Patients
Authors: Ramachandran S  , Sahithi Kiran T  , Ramam Sripada  , Supriya M  , Sudeepthi Padala  , Prabhakara Rao N  , Geeth Sai V  , Dasaratha Dhanaraju Magharla
Published: July 2020

To estimate the prevalence of retinal lesions among patients with hypertension. Hypertensive patients of both the genders above 18 years of age, who were willing to participate in the study, were included and patients who were having diabetes, previous retinal abnormalities and below 18 years of age were excluded from this study. The hypertensive patients were screened for the presence of retinal lesions and were categorised based on the severity of damage to the retinal arterioles and veins.In this study, about 876 patients who were diagnosed with hypertension were recruited and screened for retinal lesions. After screening, around 125 (14.3%) patients were observed with retinal lesions. In case of severity of retinal lesions in the hypertensive patients, most of the patients were found to be in Grade-I (40.8%) followed by Grade-II (37.6%). After treating with various types of treatment approaches, about 40 patients who were observed with retinal lesions of Grade-I severity were returned to a healthy state, and about 27 patients who were with retinal lesions of Grade-II severity were recovered to Grade-I. About six patients with retinal lesions of Grade-III was improved to Grade-II, and no patient recovered with the retinal lesions of Grade-IV severity.In this study, the prevalence of retinal lesions among the hypertensive patients was observed to be 14.3%, and the males were found to be more predominant with retinal lesions when compared to the females. The elevated blood pressure for a prolonged duration in hypertensive patients impacts the severity of retinal lesions increasing the risk of retinopathy. It is the responsibility of the clinical pharmacist to create awareness among the hypertensive patients regarding the occurrence of hypertensive retinopathy as it may cause severe complications if left untreated. Hence, regular follow-ups are required for hypertensive patients, which may help to prevent retinal complications.
Role of serum osmolarity as an indicator for neurological morbidity in children with acute central nervous illness
Authors: Linda Xavier
Published: July 2020

Acute CNS illness comprising of Acute CNS infections along with Traumatic head Injury is an important cause for significant morbidity and mortality in Pediatric Intensive Care units across the world. Osmolar changes in the blood correlate well with CNS status. Acute BM is still a meaningful, host-pathogen interaction responsible for bacterial invasion of the CNS Osmolality in children with CNS illness is a good indicator of assessing neurological Morbidity and Mortality. A complex neuroendocrine system is involved in the maintenance of sodium and water homeostasis. Bacterial Meningitis (BM) is an acute purulent infection of the meninges. It is the most common bacterial infection of the CNS& it’s the medical emergency that still has high mortality and morbidity. Blood-Brain Barrier is relatively impermeable to sodium, but water crosses freely. Variety of result in sodium dysregulation such as Traumatic Brain Injury, pyogenic meningitis, viral encephalitis, which is associated with significant Mortality and Morbidity. The objective of our study is to determine the incidence and outcome of Serum Osmolar change in children presenting with acute neurological illness. A prospective observational study was carried out between Jan 6th2020-March 6 th2020 enrolling children between ages of 1 month to 15 years, admitted to the PICU of SMCH with Acute onset neurological illness. Among 40 children, 20 children with hyponatremia have 50% of neurological deficit, Children with hypernatremia 50% had Neurological deficit, which is not statistically significant at P value0.083. Among the 40 children 40% had low Osmolality, 25% have high Osmolality& 35% had normal range, which is not statistically significant at P value 0.199