bluuebunny/crossref_metadata_2025 huggingface dataset:
New York City 1978
Authors: Horton Elizabeth E.
Published: December 2022

The city, it seems, acted as inspiration for the meeting. 330 panels, meetings, and receptions, an increase of 17 over any previous year, mirrored the surrounding variety. And, regardless of the opinion of a rather prominent editorialist, some of the Big Apple's excitement and activism infiltrated the atmosphere of our Annual Business Meeting. I know a number of political scientists who felt that it was a pretty good way to spend a Saturday afternoon.

Participants, at an all-time high of 1,457, represented almost 50 percent of those in attendance. Political Philosophy took its place again as first in attendance at the 74th Annual Meeting, with the second ranked section a good 14 points behind (see Table 1 for further details). Significantly, only three panels were reported to have over 100 persons in attendance (Table 2).
Keefe Smiling!
Authors: Baker Ross
Published: December 2022

Among the legendary thin volumes such as Ethics for Used-Car Dealers or Love Sonnets for Bureaucrats, one would invariably find a copy of The Wit and Humor of Political Science. There is an irony here and it is this: the very subject matter which is studied by political scientists—government and politics—has produced an enormous amount of humor, but those who study it rarely allow themselves the luxury of approaching the topic with levity or a sense of the absurd. How can it be that what is humorous in practice is so serious in theory? There are jokes about sports, jokes about ethnic groups, jokes about sex, and even jokes about religion but can anyone recall the last time he was elbowed in the ribs and had someone snicker to him, “Say, did you hear the latest joke about content analysis?” What would a joke about political scientists sound like? Would it go something like this? Question: How many political scientists does it take to experience love-making? The answer is three—two to ask each other how it felt and the third to determine the degree of inter-coder reliability. Pretty slim pickings on the whole until the book that is the subject of this piece of arrant puffery.
Presentation of 1981 Award to Evron M. Kirkpatrick
Authors: Peltason Jack W.
Published: December 2022

This award, The 1981 National Capital Area Political Science Association Pi Sigma Alpha Award, presented to a political scientist who has made a substantial contribution to strengthen the relationship between political science and public service, appropriately goes to one who has, more than anybody else I know, worked to strengthen the relationship between political science and public service, Evron Kirkpatrick.

Kirk's own career reflects that relationship. He studied political science at the University of Illinois where he earned a B.A. and M.A. and learned all that he knows. Then he went on to Yale in order to bring enlightenment to that area and to teach them what we had taught him at Illinois and for which they so gratefully gave him a Ph.D.

Kirk is a teacher, one of the best. He has taught at Minnesota, Howard, and Georgetown, and he has never stopped teaching throughout his demanding career.
Active circulation of varicella zoster virus among different age groups in Sudan
Authors: Adam Omer , Musa Ahmed , Kamer Amani , Benharrat Safiya , Hübschen Judith M.
Published: December 2022

In Sudan, data on varicella infections are lacking and the vaccine is currently not in use. The aim of this study was to investigate previous exposure to varicella zoster virus (VZV) among children and adults from the general population and among health-care workers (HCWs) in Khartoum. Dried blood spot samples collected between 2015 and 2016 from 294 children aged 1‒15 years, 153 adult volunteers and 241 HCWs were investigated for the presence of VZV IgG antibodies using ELISA. The overall seroprevalence of VZV IgG antibodies among the investigated cohorts was 50.4%, ranging between 14.3% in children and 79.3% in HCWs. Seropositivity increased with age among children and HCWs (P ⩽ 0.05). A relatively low seropositivity (64.7%) was observed among young adults and HCWs, suggesting that a high proportion of Sudanese adults remain susceptible. In hospital settings, this result implies a risk of nosocomial infection involving both HCWs and vulnerable patients. The results of this first VZV study in Sudan suggest active virus circulation in different age groups. Especially HCWs at the start of their career might benefit from vaccination, not only to save themselves from herpes zoster and its sequelae, but also to indirectly protect vulnerable patients.
The effect of pentoxifylline and calcium ionophore treatment on sperm cell biology in oligoasthenoteratozoospermia samples
Authors: Mahaldashtian Maryam , Khalili Mohammad Ali , Vatanparast Mahboubeh , Anbari Fatemeh , Nabi Ali , Mangoli Esmat
Published: December 2022

The objective of this study was to assess the effects of pentoxifylline (PTX) and Ca2+ ionophore (CI) A12387 treatment on some biological characteristics of sperm cells in oligoasthenoteratozoospermia (OAT) patients. After processing, each sample was divided into four groups: 1, control; 2, exposed to 3.6 mM PTX; 3, exposed to 5 μm calcium ionophore (CI); and 4, exposed to both PTX and CI; 30 min at 37°C. Sperm motility was measured before and after preparation. Acrosome reaction (AR), status of sperm vacuoles, mitochondrial membrane potential (MMP) and DNA fragmentation were assessed using PSA-FITC staining, motile sperm organelle morphology examination (MSOME), JC-1 staining and sperm chromatin dispersion (CSD) test, respectively. Treatment with PTX and CI led to increased and decreased sperm motility, respectively (P < 0.05). Furthermore, vacuole status and rates of sperm DNA fragmentation were not significantly different among groups (P > 0.05). Moreover, the data showed that the rates of AR and disrupted MMP were significantly different between groups (P < 0.05). In conclusion, in vitro application of PTX not only did not have any adverse effects on sperm cell biology characteristics, but also can rectify the harmful effect of CI.
Barriers to healthcare and their relationship to well-being and social support for autistic adults during COVID-19
Authors: Featherstone Charlotte , Sharpe Richard A. , Axford Nick , Asthana Sheena , Ball Susan , Husk Kerryn
Published: December 2022

Aim:

The present study aimed to investigate barriers to healthcare and their relationships to social and emotional well-being and intersectional inequalities for autistic adults during COVID-19 restrictions in the UK.

Background:

Autistic adults experience severe health inequalities and report more barriers to accessing health services compared to other both disabled and non-disabled populations. The COVID-19 pandemic has impacted many areas of society that may have increased vulnerability of autistic people to social and health inequalities, including delivery of healthcare from in-person to remote methods.

Method:

One hundred twenty-eight autistic adults who lived in the UK took part in an online survey. Measures included the Barriers to Healthcare Checklist (Short Form) and PROMIS outcome measure bank to assess emotional well-being and social support. Participants rated their agreement with items, retrospectively considering three different points of the trajectory of COVID-19 restrictions: before COVID-19, during the first lockdown in spring 2020, and in the month prior to taking the survey during autumn 2020. They completed a follow-up survey six months later to continue to assess change as restrictions in the UK were eased.

Findings:

The average number of barriers to healthcare showed no significant change between all four time points. However, the nature of barriers to healthcare changed at the point of lockdown and persisted beyond the easing of COVID-19 restrictions. Barriers to healthcare were associated with some social and emotional well-being variables and demographic groups including gender, education and presence of additional disabilities. The findings may help to identify areas to target to improve access to both remote and in-person health systems for autistic people as modes of delivery continue to change over time.
Modification of North Atlantic Deep Water by Pacific/Upper Circumpolar Deep Water in the Argentine Basin
Authors: Brand S. V. S. , Prend C. J. , Talley L. D.
Published: December 2022

Much of the salty, high oxygen North Atlantic Deep Water (NADW) leaving the Atlantic flows through the Argentine Basin, where it is diluted by fresher, low oxygen Circumpolar Deep Water (CDW). This mixing of deep water masses is often overlooked in the zonally averaged description of the overturning circulation. Here, we show that intense mixing occurs along the western boundary: (a) extreme, isolated oxygen/temperature anomalies recorded by three autonomous biogeochemical floats suggest that subsurface eddies can inject relatively unmodified CDW far into the northwestern Argentine Basin, and (b) moderate, numerous temperature/salinity anomalies indicate a mixing zone from Rio Grande Rise to the Malvinas Current. This western eddy pathway shortcuts the gyre‐scale cyclonic route for CDW inferred from most previous studies. Significantly, CDW dilution of NADW affects the properties of deep waters that upwell in the Southern Ocean, and hence the connection between Northern and Southern Hemisphere polar climates.
Predicted Episode of Submarine Groundwater Discharge Onto the South Carolina, USA, Continental Shelf and Its Effect on Dissolved Oxygen
Authors: Moore Willard S. , Vincent Jacob , Pickney James L. , Wilson Alicia M.
Published: December 2022

Submarine groundwater discharge (SGD) may directly influence the dissolved oxygen (DO) content of coastal bottom waters. Here, we report a predicted episode of enhanced SGD that caused low DO concentrations on the South Carolina continental shelf. The prediction model linked episodes of SGD to upwelling‐favorable winds. The data revealed these waters were a factor of 2–6 higher in 226Ra and 228Ra compared to typical bottom water values and were significantly depleted in DO (<130 μM). The tight 228Ra:226Ra correlation of these data was similar to values during a strong hypoxic event off SC in 2012. Water ages from 224Ra and 223Ra indicated the event occurred 2–9 days before sampling. The success of the prediction lends added credence to the correlation of upwelling‐favorable winds—but not necessarily accompanied by upwelling—to episodic SGD events. This prediction from wind data represents a major advance for quantifying SGD in the region.
Io Hot Spot Distribution Detected by Juno/JIRAM
Authors: Zambon F. , Mura A. , Lopes R. M. C. , Rathbun J. , Tosi F. , Sordini R. , Noschese R. , Ciarniello M. , Cicchetti A. , Adriani A. , Agostini L. , Filacchione G. , Grassi D. , Piccioni G. , Plainaki C. , Sindoni G. , Turrini D. , Brooks S. , Hansen‐Koharcheck C. , Bolton S.
Published: December 2022

In this work, we present the most updated catalog of Io hot spots based on Juno/JIRAM data. We find 242 hot spots, including 23 previously undetected. Over the half of the new hot spots identified, are located at high northern and southern latitudes (>70°). We observe a latitudinal variability and a larger concentration of hot spots in the polar regions, in particular in the North. The comparison between JIRAM and the most recent Io hot spot catalogs listing power output (Veeder et al., 2015, https://doi.org/10.1016/j.icarus.2014.07.028; de Kleer, de Pater, et al., 2019, https://doi.org/10.3847/1538-3881/ab2380), shows JIRAM detected 63% and 88% of the total number of hot spots, respectively. Furthermore, JIRAM observed 16 of the 34 faint hot spots previously identified. JIRAM data revealed thermal emission from 5 dark pateræ inferred to be active from color ratio images, thus confirming that these are hot spots.
A Large New Crater Exposes the Limits of Water Ice on Mars
Authors: Dundas Colin M. , Mellon Michael T. , Posiolova Liliya V. , Miljković Katarina , Collins Gareth S. , Tornabene Livio L. , Rangarajan Vidhya Ganesh , Golombek Matthew P. , Warner Nicholas H. , Daubar Ingrid J. , Byrne Shane , McEwen Alfred S. , Seelos Kimberly D. , Viola Donna , Bramson Ali M. , Speth Gunnar
Published: December 2022

Water ice in the Martian mid‐latitudes has advanced and retreated in response to variations in the planet's orbit, obliquity, and climate. A 150 m‐diameter new impact crater near 35°N provides the lowest‐latitude impact exposure of subsurface ice on Mars. This is the largest known ice‐exposing crater and provides key constraints on Martian climate history. This crater indicates a regional, relatively pure ice deposit that is unstable and has nearly vanished. In the past, this deposit may have been tens of meters thick and extended equatorward of 35°N. We infer that it is overlain by pore ice emplaced during temporary stable intervals, due to recent climate variability. The marginal survival of ice here suggests that it is near the edge of shallow ice that regularly exchanges with the atmosphere.
Intensification of the East Australian Current After ∼1400 CE
Authors: Zhai Ruixiang , Mohtadi Mahyar , Dolman Andrew M. , Yokoyama Yusuke , Steinke Stephan
Published: December 2022

The East Australian Current (EAC) is the western boundary current of the South Pacific Subtropical Gyre that transports warm tropical waters to higher southern latitudes and significantly impacts the climate of Australia and New Zealand. Modern observations show that the EAC has strengthened with rising global temperatures. However, little is known about the pre‐industrial variability of the EAC and the forcing mechanisms. Planktic foraminifera Globigerinoides ruber (white) Mg/Ca‐based sea surface temperature reconstructions offshore northeastern Australia between 15° and 26°S reveal an increase by ∼1.2°C after ∼1400 CE. We infer that the increase in temperature is related to a stronger EAC heat transport that is likely driven by a strengthening of the Southern Hemisphere subtropical gyre circulation due to a progressive shift of the Southern annular mode toward its positive phase and of El Niño‐Southern Oscillation toward more El Niño‐like conditions.
Increasing Precipitation in Early Winter Over the Southern China During the Past 40 years
Authors: Liu Baochao , Fang Yue , Sun Shuangwen , Yang Guang , Duan Yongliang , Tana Celia
Published: December 2022

Southern China (SC) has experienced increasing precipitation in early winter over the past 40 years, which has been attributed to increasing precipitation over the tropical Indian Ocean (TIO) in this study. In early winter, the positive diabatic heating released by the increasing precipitation over the TIO triggers a strong Matsuno–Gill response. The Kelvin wave of the Matsuno–Gill response forms an anomalous anticyclone over the Western North Pacific (WNPAC) in the lower troposphere, which strengthens water vapor transport from the ocean to SC and induces an increase in precipitation. In late winter, the increasing TIO precipitation is relatively weak, and the trend of SC precipitation is likely caused by factors outside the Indian Ocean.
History‐Dependent Volcanic Ground Deformation From Broad‐Spectrum Viscoelastic Rheology Around Magma Reservoirs
Authors: Liao Yang , Karlstrom Leif , Erickson Brittany A.
Published: December 2022

Geodetic timeseries suggest that volcanoes exhibit a wide range of deformation patterns. Viscoelastic deformation around crustal magma storage zones is an expected contributor to such observations, but is challenging to characterize robustly. Here we present a novel approach to modeling crustal deformation around magma reservoirs that identifies frequency‐domain signatures of viscoelastic response for temperature‐dependent crustal rheology. We develop a transfer function that links unsteady reservoir pressure forcing to surface displacement, finding that thermomechanical properties and geometry of the magmatic system are encoded in viscoelastic response on timescales where geodetic observations are routinely made. Inhomogeneous viscoelasticity is reflected by spatially variable relaxation of host rocks that results in a viscous aureole whose size depends on the frequency spectrum of forcing. We explore viscoelastic signatures of broadband pressurization episodes, identifying a history dependence of volcano deformation in which past activity influences the stress state and surface deformation patterns of future episodes.
Different Martian Crustal Seismic Velocities Across the Dichotomy Boundary From Multi‐Orbiting Surface Waves
Authors: Li Jiaqi , Beghein Caroline , Lognonné Philippe , McLennan Scott M. , Wieczorek Mark A. , Panning Mark P. , Knapmeyer‐Endrun Brigitte , Davis Paul , Banerdt W. Bruce
Published: December 2022

We have observed both minor‐arc (R1) and major‐arc (R2) Rayleigh waves for the largest marsquake (magnitude of 4.7 ± 0.2) ever recorded. Along the R1 path (in the lowlands), inversion results show that a simple, two‐layer model with an interface located at 21–29 km and an upper crustal shear‐wave velocity of 3.05–3.17 km/s can fit the group velocity measurements. Along the R2 path, observations can be explained by upper crustal thickness models constrained from gravity data and upper crustal shear‐wave velocities of 2.61–3.27 and 3.28–3.52 km/s in the lowlands and highlands, respectively. The shear‐wave velocity being faster in the highlands than in the lowlands indicates the possible existence of sedimentary rocks, and relatively higher porosity in the lowlands.
Fast and Slow Subpolar Ocean Responses to the North Atlantic Oscillation: Thermal and Dynamical Changes
Authors: Khatri Hemant , Williams Richard G. , Woollings Tim , Smith Doug M.
Published: December 2022

Climate model hindcasts are analyzed to reveal the impacts of the North Atlantic Oscillation (NAO) on the North Atlantic subpolar ocean, which exhibits variability on seasonal to decadal timescales. The ocean response to a single winter NAO event is separated into fast and slow responses. The fast response persists over winter–spring seasons, during which wind stress and heat flux anomalies associated with the NAO rapidly modify ocean temperatures via changes in Ekman transport and ocean‐atmosphere heat exchanges. The slow response persists for 3–4 years, during which overturning and gyre circulations redistribute opposing‐signed surface temperature anomalies created by the NAO. This redistribution modifies east‐west temperature contrasts altering the meridional heat transport associated with gyres and changing the strength of the overturning circulation. Hence, the fast and slow responses lead to opposing‐signed subpolar temperature anomalies in time from the competing effects of local forcing and horizontal heat convergence.
On the Evaluation of Solar Wind's Heating Rates
Authors: Zaslavsky A.
Published: December 2022

Solar wind heating rates have often been calculated by fitting plasma and magnetic field data with a set of model functions. In this letter, we show that the rates obtained by such an approach strongly depend on the rather arbitrary choice one makes for these model functions. An alternative approach, consisting in monitoring the radial evolution of the adiabatic invariants, based on locally and consistently measured plasma and magnetic field parameters, is free from such a flaw. We apply this technique to a recently released Helios proton data set, and confirm the existence of a clear perpendicular heating of solar wind's protons. On the other hand, no significant change in the parallel adiabatic invariant is visible in the data. We conclude that to date, and in the distance range of 0.3–1 AU, no clear observation of a deviation of solar wind's protons from parallel adiabaticity has ever been made.
Influence of Winter Subsurface on the Following Summer Variability in Northern California Current System
Authors: Ray Sulagna , Bond Nicholas , Siedlecki Samantha , Hermann Albert J.
Published: December 2022

Temperature variations in the North and tropical Pacific contribute to the predictability of temperatures along the 26.4σ isopycnal layer off the Northern California Current System (N‐CCS). Monthly temperature variations at this depth in the N‐CCS are related to a linear combination of factors, including North Pacific spice anomalies, and the PDO and ENSO climate indices. However, the mechanisms for seasonal predictability of subsurface temperatures, are not well explored. While wind and buoyancy driven deep winter mixing influence subsurface temperatures during the following summer in the deep basin of the North Pacific, a coupled atmosphere‐ocean reanalysis (the CFSR) reveals that winter prior surface temperatures explain only 25% of the summer subsurface temperatures in the N‐CCS. A heat budget of the intermediate layer between a temporally varying mixed layer and the 26.4σ level is diagnosed here to explore the possible role of oceanic advection in explaining the remaining variance. Warmer waters from the south near the coast drive temperature changes in ENSO‐neutral winters, thereby preconditioning temperatures for the following summer. During ENSO winters, isopycnal variations associated with propagating coastal kelvin waves and other sources of heaving, along with anomalous alongshore currents, drive convergence/divergence of the advective fluxes, thereby reducing the local memory of the winter subsurface temperatures. Variations in winter advection could account for almost 36% of the summer subsurface temperature variability in the N‐CCS; this exceeds the portion explained by the heat fluxes associated with deep winter mixing.
The implementation of large-scale genomic screening or diagnostic programmes: A rapid evidence review
Authors: Alarcón Garavito Germán Andrés , Moniz Thomas , Déom Noémie , Redin Federico , Pichini Amanda , Vindrola-Padros Cecilia
Published: December 2022

Genomic healthcare programmes, both in a research and clinical context, have demonstrated a pivotal opportunity to prevent, diagnose, and treat rare diseases. However, implementation factors could increase overall costs and affect uptake. As well, uncertainties remain regarding effective training, guidelines and legislation. The purpose of this rapid evidence review was to draw together the available global evidence on the implementation of genomic testing programmes, particularly on population-based screening and diagnostic programmes implemented at the national level, to understand the range of factors influencing implementation. This review involved a search of terms related to genomics, implementation and health care. The search was limited to peer-reviewed articles published between 2017–2022 and found in five databases. The review included thirty articles drawing on sixteen countries. A wide range of factors was cited as critical to the successful implementation of genomics programmes. These included having policy frameworks, regulations, guidelines; clinical decision support tools; access to genetic counselling; and education and training for healthcare staff. The high costs of implementing and integrating genomics into healthcare were also often barriers to stakeholders. National genomics programmes are complex and require the generation of evidence and addressing implementation challenges. The findings from this review highlight that there is a strong emphasis on addressing genomic education and engagement among varied stakeholders, including the general public, policymakers, and governments. Articles also emphasised the development of appropriate policies and regulatory frameworks to govern genomic healthcare, with a focus on legislation that regulates the collection, storage, and sharing of personal genomic data.
The WHO estimates of excess mortality associated with the COVID-19 pandemic
Authors: Msemburi William , Karlinsky Ariel , Knutson Victoria , Aleshin-Guendel Serge , Chatterji Somnath , Wakefield Jon
Published: December 2022

The World Health Organization has a mandate to compile and disseminate statistics on mortality, and we have been tracking the progression of the COVID-19 pandemic since the beginning of 20201. Reported statistics on COVID-19 mortality are problematic for many countries owing to variations in testing access, differential diagnostic capacity and inconsistent certification of COVID-19 as cause of death. Beyond what is directly attributable to it, the pandemic has caused extensive collateral damage that has led to losses of lives and livelihoods. Here we report a comprehensive and consistent measurement of the impact of the COVID-19 pandemic by estimating excess deaths, by month, for 2020 and 2021. We predict the pandemic period all-cause deaths in locations lacking complete reported data using an overdispersed Poisson count framework that applies Bayesian inference techniques to quantify uncertainty. We estimate 14.83 million excess deaths globally, 2.74 times more deaths than the 5.42 million reported as due to COVID-19 for the period. There are wide variations in the excess death estimates across the six World Health Organization regions. We describe the data and methods used to generate these estimates and highlight the need for better reporting where gaps persist. We discuss various summary measures, and the hazards of ranking countries’ epidemic responses.
Primate gastrulation and early organogenesis at single-cell resolution
Authors: Zhai Jinglei , Guo Jing , Wan Haifeng , Qi Luqing , Liu Lizhong , Xiao Zhenyu , Yan Long , Schmitz Daniel A. , Xu Yanhong , Yu Dainan , Wu Xulun , Zhao Wentao , Yu Kunyuan , Jiang Xiangxiang , Guo Fan , Wu Jun , Wang Hongmei
Published: December 2022

Our understanding of human early development is severely hampered by limited access to embryonic tissues. Due to their close evolutionary relationship with humans, nonhuman primates are often used as surrogates to understand human development but currently suffer from a lack of in vivo datasets, especially from gastrulation to early organogenesis during which the major embryonic cell types are dynamically specified. To fill this gap, we collected six Carnegie stage 8–11 cynomolgus monkey (Macaca fascicularis) embryos and performed in-depth transcriptomic analyses of 56,636 single cells. Our analyses show transcriptomic features of major perigastrulation cell types, which help shed light on morphogenetic events including primitive streak development, somitogenesis, gut tube formation, neural tube patterning and neural crest differentiation in primates. In addition, comparative analyses with mouse embryos and human embryoids uncovered conserved and divergent features of perigastrulation development across species—for example, species-specific dependency on Hippo signalling during presomitic mesoderm differentiation—and provide an initial assessment of relevant stem cell models of human early organogenesis. This comprehensive single-cell transcriptome atlas not only fills the knowledge gap in the nonhuman primate research field but also serves as an invaluable resource for understanding human embryogenesis and developmental disorders.
An increase in mitochondrial TOM activates apoptosis to drive retinal neurodegeneration
Authors: Periasamy Agalya , Mitchell Naomi , Zaytseva Olga , Chahal Arjun S. , Zhao Jiamin , Colman Peter M. , Quinn Leonie M. , Gulbis Jacqueline M.
Published: December 2022

Intronic polymorphicTOMM40variants increasingTOMM40mRNA expression are strongly correlated to late onset Alzheimer’s Disease. The gene product, hTomm40, encoded in theAPOEgene cluster, is a core component of TOM, the translocase that imports nascent proteins across the mitochondrial outer membrane. We usedDrosophila melanogastereyes as an in vivo model to investigate the relationship between elevated Tom40 (theDrosophilahomologue of hTomm40) expression and neurodegeneration. Here we provide evidence that an overabundance of Tom40 in mitochondria invokes caspase-dependent cell death in a dose-dependent manner, leading to degeneration of the primarily neuronal eye tissue. Degeneration is contingent on the availability of co-assembling TOM components, indicating that an increase in assembled TOM is the factor that triggers apoptosis and degeneration in a neural setting. Eye death is not contingent on inner membrane translocase components, suggesting it is unlikely to be a direct consequence of impaired import. Another effect of heightened Tom40 expression is upregulation and co-association of a mitochondrial oxidative stress biomarker,DmHsp22, implicated in extension of lifespan, providing new insight into the balance between cell survival and death. Activation of regulated death pathways, culminating in eye degeneration, suggests a possible causal route fromTOMM40polymorphisms to neurodegenerative disease.
Study the effect of drying on the oxidation thermogravimetric and functional group composition characteristics of immersed lignite
Authors: Guo Wei , Zhang Chunhua , Han Yongliang
Published: December 2022

The drying process of immersed lignite has a significant influence on the characteristics and progress of spontaneous combustion. To reveal the influence mechanism of the drying process of immersed coal on the spontaneous combustion characteristics and the change rule of the spontaneous combustion process, in this research, we measured the mass change during coal oxidation with thermogravimetry, and the change of the functional groups with Fourier transform infrared spectroscopy. The influence of the drying process on the coal was analyzed by comparing activation energy, functional group of immersed coal with different drying degrees and raw coal. The results showed that, compared with raw coal, the content of Ar–C–O– and antisymmetric stretching vibration of the carboxylate group (–COO–) as well as the stretching vibration in the quinone group (C=O) and the –OH group increased. For the content of $$\delta s.{\text{RCH}}_{{3}}$$

δ
s
.

RCH
3

,$$\delta as.{\text{R}}_{{2}} {\text{CH}}_{2}$$

δ
a
s
.

R
2

CH
2

$$\delta as.{\text{RCH}}_{{3}}$$

δ
a
s
.

RCH
3

, the value of Asym.CH2/Asym.CH3 decreased. The content of various functional groups changed to be favorable for oxidation and heat release. At different reaction stages, the activation energy was differently affected by the degree of drying. Average values of activation energies at different reaction stages are shown raw coal had the lowest activation energy. After soaking in water and drying, the activation energy of coal is increased to varying degrees, the reactivity is reduced, and the risk of spontaneous combustion is reduced. After soaking in water and drying, the activation energy of coal is increased to varying degrees, the reactivity is reduced, and the risk of spontaneous combustion is reduced. The activation energy of the coal samples dried for 24 h after soaking in water is the lowest among the coal samples dried for different times after soaking in water, and the moisture content is 10.5%.
Edaphic controls of soil organic carbon in tropical agricultural landscapes
Authors: Wells Jon M. , Crow Susan E. , Sierra Carlos A. , Deenik Jonathan L. , Carlson Kimberly M. , Meki Manyowa N. , Kiniry Jim
Published: December 2022

Predicting soil organic carbon (SOC) is problematic in tropical soils because mechanisms of SOC (de)stabilization are not resolved. We aimed to identify such storage mechanisms in a tropical soil landscape constrained by 100 years of similar soil inputs and agricultural disturbance under the production of sugarcane, a C4 grass and bioenergy feedstock. We measured soil physicochemical parameters, SOC concentration, and SOC dynamics by soil horizon to one meter to identify soil parameters that can predict SOC outcomes. Applying correlative analyses, linear mixed model (LMM) regression, model selection by AICc, and hierarchical clustering we found that slow moving SOC was related to many soil parameters, while the fastest moving SOC was only related to soil surface charge. Our models explained 78–79%, 51–57%, 7–8% of variance in SOC concentration, slow pool decay, and fast pool decay, respectively. Top SOC predictors were roots, the ratio of organo-complexed iron (Fe) to aluminum (Al), water stable aggregates (WSagg), and cation exchange capacity (CEC). Using hierarchical clustering we also assessed SOC predictors across gradients of depth and rainfall with strong reductions in Roots, SOC, and slow pool decay associated with increasing depth, while increased rainfall was associated with increased Clay and WSagg and reduced CEC in surface soils. Increased negative surface charge, water stable aggregation, organo-Fe complexation, and root inputs were key SOC protection mechanisms despite high soil disturbance. Further development of these relationships is expected to improve understanding of SOC storage mechanisms and outcomes in similar tropical agricultural soils globally.
Canopy dieback and recovery in Australian native forests following extreme drought
Authors: Losso Adriano , Challis Anthea , Gauthey Alice , Nolan Rachael H. , Hislop Samuel , Roff Adam , Boer Matthias M. , Jiang Mingkai , Medlyn Belinda E. , Choat Brendan
Published: December 2022

In 2019, south-eastern Australia experienced its driest and hottest year on record, resulting in massive canopy dieback events in eucalypt dominated forests. A subsequent period of high precipitation in 2020 provided a rare opportunity to quantify the impacts of extreme drought and consequent recovery. We quantified canopy health and hydraulic impairment (native percent loss of hydraulic conductivity, PLC) of 18 native tree species growing at 15 sites that were heavily impacted by the drought both during and 8–10 months after the drought. Most species exhibited high PLC during drought (PLC:65.1 ± 3.3%), with no clear patterns across sites or species. Heavily impaired trees (PLC > 70%) showed extensive canopy browning. In the post-drought period, most surviving trees exhibited hydraulic recovery (PLC:26.1 ± 5.1%), although PLC remained high in some trees (50–70%). Regained hydraulic function (PLC < 50%) corresponded to decreased canopy browning indicating improved tree health. Similar drought (37.1 ± 4.2%) and post-drought (35.1 ± 4.4%) percentages of basal area with dead canopy suggested that trees with severely compromised canopies immediately after drought were not able to recover. This dataset provides insights into the impacts of severe natural drought on the health of mature trees, where hydraulic failure is a major contributor in canopy dieback and tree mortality during extreme drought events.
Clinical outcomes of posttransplantation diabetes mellitus in kidney transplantation recipients: a nationwide population-based cohort study in Korea
Authors: Kang Eunjeong , Lee Jangwook , Kang Dong Hyun , Park Jina , Park Sehoon , Kim Yong Chul , Kim Dong Ki , Joo Kwon Wook , Kim Yon Su , Park Minsu , Lim Yaeji , Lee Hajeong
Published: December 2022

Posttransplantation diabetes mellitus (PTDM) is an important metabolic complication after KT that causes graft failure and cardiovascular complications in kidney transplantation (KT) recipients. Using the national claim data of South Korea, 7612 KT recipients between 2009 and 2017 were analyzed. PTDM was defined as a consecutive 30-day prescription history of antidiabetic medication after KT. Among these patients, 24.7% were diagnosed with PTDM, and 51.9% were diagnosed within 6 months after KT. Compared to patients without PTDM, those with PTDM were older, more likely to be men, more likely to be diagnosed with hypertension and cardio-cerebrovascular disease, and experienced more rejection episodes requiring high-dose steroid treatment after KT. During the follow-up, 607 DCGFs, 230 DWGFs, 244 MACEs, and 260 all-cause mortality events occurred. Patients with PTDM showed a higher risk of DCGF (adjusted hazard ratio [aHR] 1.49; 95% confidence interval [CI] 1.22–1.82; P < 0.001) and MACEs (aHR 1.76; 95% CI 1.33–2.31; P < 0.001) than patients without PTDM. The risks for all clinical outcomes were higher in the insulin group than in the non-use insulin group. PTDM in KT recipients resulted in both worse allograft and patient outcomes represented by DCGF and MACE, especially in patients needing insulin treatment.
The impact of depression and physical multimorbidity on health-related quality of life in China: a national longitudinal quantile regression study
Authors: Pan Tianxin , Anindya Kanya , Devlin Nancy , Mercer Stewart W. , McPake Barbara , van Heusden Alex , Zhao Yang , Hao Xiuqi , Marthias Tiara , Lee John Tayu
Published: December 2022

The co-occurrence of mental and physical chronic conditions is a growing concern and a largely unaddressed challenge in low-and-middle-income countries. This study aimed to investigate the independent and multiplicative effects of depression and physical chronic conditions on health-related quality of life (HRQoL) in China, and how it varies by age and gender. We used two waves of the China Health and Retirement Longitudinal Study (2011, 2015), including 9227 participants aged ≥ 45 years, 12 physical chronic conditions and depressive symptoms. We used mixed-effects linear regression to assess the effects of depression and physical multimorbidity on HRQoL, which was measured using a proxy measure of Physical Component Scores (PCS) and Mental Component Scores (MCS) of the matched SF-36 measure. We found that each increased number of physical chronic conditions, and the presence of depression were independently associated with lower proxy PCS and MCS scores. There were multiplicative effects of depression and physical chronic conditions on PCS (− 0.83 points, 95% CI − 1.06, − 0.60) and MCS scores (− 0.50 points, 95% CI − 0.73, − 0.27). The results showed that HRQoL decreased markedly with multimorbidity and was exacerbated by the presence of co-existing physical and mental chronic conditions.
Distribution and postnatal development of chondroitin sulfate proteoglycans in the perineuronal nets of cholinergic motoneurons innervating extraocular muscles
Authors: Ritok Adrienn , Kiss Peter , Zaher Anas , Wolf Ervin , Ducza Laszlo , Bacskai Timea , Matesz Clara , Gaal Botond
Published: December 2022

Fine control of extraocular muscle fibers derives from two subpopulations of cholinergic motoneurons in the oculomotor-, trochlear- and abducens nuclei. Singly- (SIF) and multiply innervated muscle fibers (MIF) are supplied by the SIF- and MIF motoneurons, respectively, representing different physiological properties and afferentation. SIF motoneurons, as seen in earlier studies, are coated with chondroitin sulfate proteoglycan rich perineuronal nets (PNN), whereas MIF motoneurons lack those. Fine distribution of individual lecticans in the composition of PNNs and adjacent neuropil, as well as the pace of their postnatal accumulation is, however, still unknown. Therefore, the present study aims, by using double immunofluorescent identification and subsequent morphometry, to describe local deposition of lecticans in the perineuronal nets and neuropil of the three eye movement nuclei. In each nucleus PNNs were consequently positive only with WFA and aggrecan reactions, suggesting the dominating role of aggrecan is PNN establishment. Brevican, neurocan and versican however, did not accumulate at all in PNNs but were evenly and moderately present throughout the neuropils. The proportion of PNN bearing motoneurons appeared 76% in oculomotor-, 72.2% in trochlear- and 78.3% in the abducens nucleus. We also identified two morphological subsets of PNNs, the focal and diffuse nets of SIF motoneurons. The process of CSPG accumulation begins just after birth, although considerable PNNs occur at week 1 age around less than half of the motoneurons, which ratio doubles until 2-month age. These findings may be related to the postnatal establishment of the oculokinetic network, performing different repertoires of voluntary eye movements in functionally afoveolate and foveolate animals.
Current-state opacity verification in discrete event systems using an observer net
Authors: Labed Abdeldjalil , Saadaoui Ikram , Wu Naiqi , Yu Jiaxin , Li Zhiwu
Published: December 2022

Due to the proliferation of contemporary computer-integrated systems and communication networks, there is more concern than ever regarding privacy, given the potential for sensitive data exploitation. A recent cyber-security research trend is to focus on security principles and develop the foundations for designing safety-critical systems. In this work, we investigated the problem of verifying current-state opacity in discrete event systems using labeled Petri nets. A system is current-state opaque provided that the current-state estimate cannot be revealed as a subset of secret states. We introduced a new sub-model of the system, named an observer net. The observer net have the same structure as the plant, but it is distinguished by the use of colored markers as well as simultaneous and recursive transition enabling and firing, which offer an efficient state estimation. We considered two settings of the proposed approach: an on-line setting, in which a current-state opacity algorithm is proposed. The algorithm waits for the occurrence of an observable event and determines if the current observation of a plant reveals the secret behaviour, as well as, an off-line setting, where the verification problem is solved based on a state estimator called a colored estimator. In this context, necessary and sufficient conditions for verifying opacity are developed with illustrative examples to demonstrate the presented approach.
Unemployment and hair cortisol as a biomarker of chronic stress
Authors: Lawes Mario , Hetschko Clemens , Schöb Ronnie , Stephan Gesine , Eid Michael
Published: December 2022

Unemployment is widely considered an important chronic stressor. Using longitudinal data of initially employed German jobseekers, the present study examines whether unemployment is related to changes in hair cortisol concentration (HCC), a reliable biomarker for chronic stress. The results indicate that HCC is the highest initially when individuals are insecurely employed and decreases as people gain certainty about whether they enter unemployment or not. We find no effects when comparing the average changes in HCC between individuals who entered unemployment to those of continuously employed individuals. However, medium-term unemployment was associated with a stronger mean increase in HCC if re-employment expectations were low compared to when re-employment expectations were high. Taken together, our results support two key conclusions. First, experiencing the uncertainty of looming unemployment is associated with more pronounced cortisol secretion than unemployment itself. Second, whether working or being unemployed is associated with higher HCC is highly context-dependent, with poor re-employment prospects during unemployment being a key predictor of increased HCC. Overall, our study provides further evidence that the physiological stress system is especially sensitive to uncontrollable situations and unfamiliar challenge.
Differential diagnosis of thyroid nodule capsules using random forest guided selection of image features
Authors: Eftimie Lucian G. , Glogojeanu Remus R. , Tejaswee A. , Gheorghita Pavel , Stanciu Stefan G. , Chirila Augustin , Stanciu George A. , Paul Angshuman , Hristu Radu
Published: December 2022

Microscopic evaluation of tissue sections stained with hematoxylin and eosin is the current gold standard for diagnosing thyroid pathology. Digital pathology is gaining momentum providing the pathologist with additional cues to traditional routes when placing a diagnosis, therefore it is extremely important to develop new image analysis methods that can extract image features with diagnostic potential. In this work, we use histogram and texture analysis to extract features from microscopic images acquired on thin thyroid nodule capsules sections and demonstrate how they enable the differential diagnosis of thyroid nodules. Targeted thyroid nodules are benign (i.e., follicular adenoma) and malignant (i.e., papillary thyroid carcinoma and its sub-type arising within a follicular adenoma). Our results show that the considered image features can enable the quantitative characterization of the collagen capsule surrounding thyroid nodules and provide an accurate classification of the latter’s type using random forest.
Graph neural network-based cell switching for energy optimization in ultra-dense heterogeneous networks
Authors: Tan Kang , Bremner Duncan , Le Kernec Julien , Sambo Yusuf , Zhang Lei , Imran Muhammad Ali
Published: December 2022

The development of ultra-dense heterogeneous networks (HetNets) will cause a significant rise in energy consumption with large-scale base station (BS) deployments, requiring cellular networks to be more energy efficient to reduce operational expense and promote sustainability. Cell switching is an effective method to achieve the energy efficiency goals, but traditional heuristic cell switching algorithms are computationally demanding with limited generalization abilities for ultra-dense HetNet applications, motivating the usage of machine learning techniques for adaptive cell switching. Graph neural networks (GNNs) are powerful deep learning models with strong generalization abilities but receive little attention for cell switching. This paper proposes a GNN-based cell switching solution (GBCSS) that has a smaller computational complexity than existing heuristic algorithms. The presented performance evaluation uses the Milan telecommunication dataset based on real-world call detail records, comparing GBCSS with a traditional exhaustive search (ES) algorithm, a state-of-the-art learning-based algorithm, and the baseline without cell switching. Results indicate that GBCSS achieves a 10.41% energy efficiency gain when compared with the baseline and achieves 75.76% of the optimal performance obtained with ES algorithm. The results also demonstrate GBCSS’ significant scalability and generalization abilities to differing load conditions and the number of BSs, suggesting this approach is well-suited to ultra-dense HetNet deployment.
Exposome approach for identifying modifiable factors for the prevention of colorectal cancer
Authors: Chen Nanqian , Liang Hailun , Huang Tao , Huang Ninghao
Published: December 2022

Previous studies have shown certain exposure factors (such as lifestyle and metabolism) are associated with colorectal cancer (CRC) events. However, the application of the exposome theoretical frame and the extent to which the exposome domain can modulate the risk of CRC remain unknown. Our study aimed to construct valid exposome measurements and examine the relationship between exposome counts and the risk of CRC. This study included 335,370 individuals in the UK Biobank. We used exploratory factor analysis to identify a valid construct of exposome factors. We then summed the exposome counts within each domain. Cox proportional hazard models were used to estimate the hazard ratios and 95% confidence intervals of CRC risk related to the exposome factors and counts. During an 8.69 year median follow-up, 10,702 CRC cases were identified. Five domains were extracted from 12 variables, including ecosystem, lifestyle, tobacco and alcohol use, social economics, and social support. The Cox model results showed that the ecosystem was positively related to the reduced CRC risk (HR = 0.970; 95% CI 0.952–0.989). Similar results were also found among the domains of healthy lifestyles (HR = 0. 889; 95% CI 0.871–0.907), and no tobacco and alcohol use (HR = 0.892; 95% CI 0.876–0.909). The disadvantageous social economic (HR = 1.081; 95% CI 1.058–1.105) and insufficient social support domains (HR = 1.036; 95% CI 1.017–1.056) were associated with an increased risk of CRC. Similar risk trends were also observed across the exposome count groups with CRC incidence. Our findings suggest that certain exposure domains are related to the incidence of CRC. Ecosystem, lifestyle, and social factors can be incorporated into prediction models to identify individuals at high risk of CRC.