bluuebunny/crossref_metadata_2025 huggingface dataset:
The Value of Electronically Extracted Data for Auditing Outpatient Antimicrobial Prescribing
Authors: Livorsi Daniel J. , Linn Carrie M. , Alexander Bruce , Heintz Brett H. , Tubbs Traviss A. , Perencevich Eli N.
Published: December 2017

OBJECTIVE

The optimal approach to auditing outpatient antimicrobial prescribing has not been established. We assessed how different types of electronic data—including prescriptions, patient-visits, and International Classification of Disease, Tenth Revision (ICD-10) codes—could inform automated antimicrobial audits.

DESIGN

Outpatient visits during 2016 were retrospectively reviewed, including chart abstraction, if an antimicrobial was prescribed (cohort 1) or if the visit was associated with an infection-related ICD-10 code (cohort 2). Findings from cohorts 1 and 2 were compared.

SETTING

Primary care clinics and the emergency department (ED) at the Iowa City Veterans Affairs Medical Center.

RESULTS

In cohort 1, we reviewed 2,353 antimicrobial prescriptions across 52 providers. ICD-10 codes had limited sensitivity and positive predictive value (PPV) for validated cases of cystitis and pneumonia (sensitivity, 65.8%, 56.3%, respectively; PPV, 74.4%, 52.5%, respectively). The volume-adjusted antimicrobial prescribing rate was 13.6 per 100 ED visits and 7.5 per 100 primary care visits. In cohort 2, antimicrobials were not indicated in 474 of 851 visits (55.7%). The antimicrobial overtreatment rate was 48.8% for the ED and 59.7% for primary care. At the level of the individual prescriber, there was a positive correlation between a provider’s volume-adjusted antimicrobial prescribing rate and the individualized rates of overtreatment in both the ED (r=0.72; P<.01) and the primary care setting (r=0.82; P=0.03).

CONCLUSIONS

In this single-center study, ICD-10 codes had limited sensitivity and PPV for 2 infections that typically require antimicrobials. Electronically extracted data on a provider’s rate of volume-adjusted antimicrobial prescribing correlated with the frequency at which unnecessary antimicrobials were prescribed, but this may have been driven by outlier prescribers.

Infect Control Hosp Epidemiol 2018;39:64–70
Not All Roads Lead to Rome: A Meta-analysis of Invasive Plant Impact Methodology
Authors: Tekiela Daniel R. , Barney Jacob N.
Published: December 2017

The negative effects of invasive plant species on native ecosystems, which can be large and long-lasting, are the primary justifications for their research and management. Tremendous effort is focused on quantifying the ecological impacts of invasive plants, though two different methods are primarily used: observational (compare invaded and uninvaded) and removals (compare invaded and invader removal). However, it is unknown whether these methods, which differ in their assumptions and execution, yield similar results, which could affect our ability to draw broad conclusions within and across studies. Therefore, we performed a meta-analysis on 174 studies that described 547 impacts of 72 invasive plants to test the effect of study method, invader cover, and removal period on the direction and magnitude of impact. Overall, by only considering impact magnitude and not direction, both observational and removal methods yielded similar results—invasive plants are changing most aspects of the ecosystem—and the variation among species and study systems was dramatically reduced compared with traditional, directionally focused studies. This is contrary to a similar analysis that did not control for directionality of impacts, which found overall differences in impact depended on methodology. However, even when the effects of study ecosystem, invader life-form, and impact type were accounted for, significant differences occurred between removal and observational studies. Particularly vulnerable systems appear to be those that would be more greatly disturbed by the removal of the target species, such as tree species or invasive plants in riparian areas. Additionally, impact magnitude increased with invader cover and removal time. We confirm that invasive plants impact the systems they invade in a nonuniform manner; however, we suggest some study conditions may be more sensitive to study methodology. Careful consideration should be given as to which methodology is used in the context of the study system.
Malnutrition and cachexia among cancer out-patients in Nairobi, Kenya
Authors: Kaduka L. U. , Bukania Z. N. , Opanga Y. , Mutisya R. , Korir A. , Thuita V. , Nyongesa C. , Mwangi M. , Mbakaya C. F. L. , Muniu E.
Published: December 2017

Cancer is the third leading cause of death in Kenya. However, there is scarce information on the nutritional status of cancer patients to guide in decision making. The present study sought to assess the risk of malnutrition, and factors associated with malnutrition and cachexia, among cancer out-patients, with the aim of informing nutrition programmes for cancer management in Kenya and beyond. This was a facility-based cross-sectional study performed at Kenyatta National Hospital and Texas Cancer Centre in Nairobi, Kenya. The risk of malnutrition was assessed using the Malnutrition Universal Screening Tool (MUST). Diagnoses of malnutrition and cachexia were done using the European Society of Clinical Nutrition and Metabolism (ESPEN) and Fearon criteria, respectively. A total of 512 participants were assessed. Those at risk of malnutrition were 33·1 % (12·5 % at medium risk, 20·6 % at high risk). Prevalence of malnutrition was 13·4 %. The overall weight loss >5 % over 3 months was 18·2 % and low fat-free mass index was 43·1 %. Prevalence of cachexia was 14·1 % compared with 8·5 % obtained using the local criteria. Only 18·6 % participants had received any form of nutrition services. Age was a predictor of malnutrition and cachexia in addition to site of cancer for malnutrition and cigarette smoking for cachexia. The use of the MUST as a screening tool at the first point of care should be explored. The predictive value of current nutrition assessment tools, and the local diagnostic criteria for malnutrition and cachexia should be reassessed to inform the development of appropriate clinical guidelines and future capacity-building initiatives that will ensure the correct identification of patients at risk for timely care.
Patterns in glacial-earthquake activity around Greenland, 2011–13
Authors: OLSEN KIRA G. , NETTLES MEREDITH
Published: December 2017

Glacial earthquakes are caused by large iceberg calving events, which are an important mechanism for mass loss from the Greenland ice sheet. The number of glacial earthquakes in Greenland has increased sixfold over the past two decades. We use teleseismic surface waves to analyze the 145 glacial earthquakes that occurred in Greenland from 2011 through 2013, and successfully determine source parameters for 139 events at 13 marine-terminating glaciers. Our analysis increases the number of events in the glacial-earthquake catalog by nearly 50% and extends it to 21 years. The period 2011–13 was the most prolific 3-year period of glacial earthquakes on record, with most of the increase over earlier years occurring at glaciers on Greenland's west coast. We investigate changes in earthquake productivity and geometry at several individual glaciers and link patterns in glacial-earthquake production and cessation to the absence or presence of a floating ice tongue. We attribute changes in earthquake force orientations to changes in calving-front geometry, some of which occur on timescales of days to months. Our results illustrate the utility of glacial earthquakes as a remote-sensing tool to identify the type of calving event, the grounded state of a glacier, and the orientation of an active calving front.
Using structure from motion photogrammetry to measure past glacier changes from historic aerial photographs
Authors: VARGO LAUREN J. , ANDERSON BRIAN M. , HORGAN HUW J. , MACKINTOSH ANDREW N. , LORREY ANDREW M. , THORNTON MERIJN
Published: December 2017

Quantifying historic changes in glacier size and mass balance is important for understanding how the cryosphere responds to climate variability and change. Airborne photogrammetry enables glacier extent and equilibrium line altitudes (ELAs) to be monitored for more glaciers at lower cost than traditional mass-balance programs and other remote-sensing techniques. Since 1977, end-of-summer-snowlines, which are a proxy for annual ELAs, have been recorded for 50 glaciers in the Southern Alps of New Zealand using oblique aerial photographs. In this study, we use structure from motion photogrammetry to estimate the camera parameters, including position, for historic photographs, which we then use to measure glacier change. We apply this method to a small maritime New Zealand glacier (Brewster Glacier, 1670–2400 m a.s.l.) to derive annual ELA and length records between 1981 and 2017, and quantify the uncertainties associated with the method. Our length reconstruction shows largely continuous terminus retreat of 365 ± 12 m for Brewster Glacier since 1981. The ELA record, which compares well with glaciological mass-balance data measured between 2005 and 2015, shows pronounced interannual variability. Mean ELAs range from 1707 ± 6 to 2303 ± 5 m a.s.l., with the highest ELAs occurring in the last decade.
Superficial Harmony and Conflict Avoidance Resulting from Negative Anticipation in the Workplace
Authors: Zhang Zhi-Xue , Wei Xin
Published: December 2017

This research examines how people perceive and respond to potential conflict in work settings. When individuals highly value their interpersonal relationships with others, they may take the potential costs to relationships into consideration in deciding how to handle conflict. We propose that individuals take an avoidance approach to conflict to prevent disruption in relationships from confrontation. Specifically, the value that individuals place on superficial harmony is positively related to their negative anticipation of relationship costs, which in turn leads to conflict avoidance. Furthermore, the direct relationship between superficial harmony and negative anticipation and the indirect relationship between superficial harmony and conflict avoidance are negatively moderated by the closeness of relations between the parties involved. The results of two studies conducted in workplace settings supported our hypothesized moderated mediation model. Highlighting the role of superficial harmony in conflict avoidance, this research contributes to the existing literature on conflict management and has practical implications for effectively managing conflict in the workplace.
Unlocking Expatriates’ Job Creativity: The Role of Cultural Learning, and Metacognitive and Motivational Cultural Intelligence
Authors: Xu Xiao-Jun , Chen Xiao-Ping
Published: December 2017

In this article, we extend Amabile's componential theory of creativity to account for cross-cultural creativity by conceptualizing cultural learning as a crucial component in the creativity relevant process. We hypothesize a significant positive relationship between cultural learning and expatriates’ cross-cultural job creativity, and that this relationship will be enhanced by domain learning and the cultural distance between the host and home countries. Moreover, we propose that expatriates with higher metacognitive and motivational cultural intelligence will engage in greater cultural learning, which in turn will be related to job creativity. Data from 219 expatriate-supervisor dyads of 36 Chinese multinational companies reveal that metacognitive CQ and motivational CQ are indeed positive antecedents to cultural learning, which in turn positively relates to cross-cultural job creativity, especially for high domain learning expatriates who work in a foreign culture not vastly different from home. Our findings make significant contributions to the existing literature on creativity and provide nuanced understanding of the relationship between cultural intelligence, cultural learning and cross-cultural job creativity. Our findings also have important implications for expatriate management.
A Giant of Cultural Research: Seeing Further from the Shoulders of Kwok Leung
Authors: Morris Michael W. , Chen Zhen Xiong (George) , Doucet Lorna , Gong Yaping
Published: December 2017

This is a special issue in honor of Kwok Leung, whose path-breaking career in social psychology, cross-cultural psychology, organizational behavior, and international management was cut short by his untimely death in 2015. Newton said, ‘If I have seen further it is by standing on the shoulders of giants’. In cultural research, it's Kwok's shoulders that enable us to see further.
Differential Contributions of Selective Attention and Sensory Integration to Driving Performance in Healthy Aging and Alzheimer’s Disease
Authors: Venkatesan Umesh M. , Festa Elena K. , Ott Brian R. , Heindel William C.
Published: December 2017

Objectives:Patients with Alzheimer’s disease (AD) demonstrate deficits in cross-cortical feature binding distinct from age-related changes in selective attention. This may have consequences for driving performance given its demands on multisensory integration. We examined the relationship of visuospatial search and binding to driving in patients with early AD and elderly controls (EC).Methods:Participants (42 AD; 37 EC) completed search tasks requiring either luminance-motion (L-M) or color-motion (C-M) binding, analogs of within and across visual processing stream binding, respectively. Standardized road test (RIRT) and naturalistic driving data (CDAS) were collected alongside clinical screening measures.Results:Patients performed worse than controls on most cognitive and driving indices. Visual search and clinical measures were differentially related to driving behavior across groups. L-M search and Trail Making Test (TMT-B) were associated with RIRT performance in controls, while C-M binding, TMT-B errors, and Clock Drawing correlated with CDAS performance in patients. After controlling for demographic and clinical predictors, L-M reaction time significantly predicted RIRT performance in controls. In patients, C-M binding made significant contributions to CDAS above and beyond demographic and clinical predictors. RIRT and C-M binding measures accounted for 51% of variance in CDAS performance in patients.Conclusions:Whereas selective attention is associated with driving behavior in EC, cross-cortical binding appears most sensitive to driving in AD. This latter relationship may emerge only in naturalistic settings, which better reflect patients’ driving behavior. Visual integration may offer distinct insights into driving behavior, and thus has important implications for assessing driving competency in early AD. (JINS, 2018,24, 486–497)
Innovation in functional categories:slash, a new coordinator in English
Authors: WOO BRENT
Published: December 2017

This article presents an analysis of the distribution and syntactic behavior of the English expressionslash, as inJohn is a linguist slash musician. The interpretation of this ‘effableslash’ is largely equivalent to intersectiveand, but it differs from other connective devices like Latincum, N–N compounding and the orthographic slash </>. A corpus study of American English finds thatslashis productive in this use. Its syntactic properties confirm its status as coordinator, but it is distinguished from standard coordinatorsandandor, in that it imposes category restrictions on the conjuncts: it cannot coordinate full clauses or noun phrases with determiners. I propose that words likeslash,periodandquoteform a class of ‘effable punctuation’ that entered the spoken language from writing. In sum, by incorporatingslashinto the grammar of English, I argue thatslashis a rare example of innovation in a ‘very closed’ functional category.
The Treatment of Regulatory Convergence in Preferential Trade Agreements
Authors: POLANCO LAZO RODRIGO , SAUVÉ PIERRE
Published: December 2017

This article explores the concept of ‘regulatory convergence’ in the context of the evolving literature on legal convergence and divergence. Such a concept has emerged as an overarching horizontal discipline in the latest generation of preferential trade agreements and aims to reduce unnecessary regulatory incompatibilities between countries in order to facilitate cross-border trade and investment.

Differing approaches to regulatory convergence found in recently concluded PTAs, or are currently under negotiation, are examined, with a special focus on the ‘regulatory cooperation’ approach embedded in CETA, the path of ‘regulatory improvement’ taken by members of the Pacific Alliance, and the ‘regulatory coherence’ track included in the TPP. We also refer to the TTIP negotiations conducted between the EU and the US.

The article offers a broad understanding of the different ways in which regulatory convergence is implemented across PTAs, and the legal complexities resulting from the ambiguity of the concept. It further describes the scope and effects of the different mechanisms used to achieve regulatory convergence, on both substantive and procedural matters.
Examining cancer survivorship trajectories: Exploring the intersection between qualitative illness narratives and quantitative screening instruments
Authors: Ratcliff Chelsea , Naik Aanand D. , Martin Lindsey Ann , Moye Jennifer
Published: December 2017

Objective

This article examines the associations of quantitatively refined trajectories of adjustment to cancer survivorship determined by previously published qualitative narrative analysis.

Method

Patients completed measures of cancer-related worry (Cancer Related Worries Scale), depression (Patient Health Questionnaire-9), posttraumatic growth (Benefit Finding Scale), and open-ended survey questions 6, 12, and 18 months postdiagnosis of head and neck, esophageal, gastric, or colorectal cancer. Previously published narrative analysis revealed five distinct survivorship “paths,” which were combined into four paths in the present article: Moving On, Seeing the World Differently, Taking One Day at a Time, and Never the Same. To determine the association of qualitatively determined paths with quantitatively assessed adjustment (i.e., Cancer Related Worries Scale, Patient Health Questionnaire-9, Benefit Finding Scale), we used linear multilevel modeling to regress the adjustment variables on time, path, the time-by-path interaction, and relevant covariates (age, stage, cancer site, ethnicity, and Deyo score).

Results

There was a significant main effect of path on cancer worry, depression, and posttraumatic growth (p< 0.02 for all). Patients in the Moving On group reported consistently low worry, depression, and growth compared to the other groups. Patients in the Seeing the World Differently and Taking One Day at a Time paths both reported moderate worry and depression; but those in the Seeing the World Differently path reported the highest posttraumatic growth, whereas patients in the Taking One Day at a Time path reported little growth. Finally, patients in the Never the Same path reported the highest worry and depression but lowest posttraumatic growth.

Significance of results

This longitudinal study reinforces the notion that cancer survivorship is not a one-size-fits-all experience nor a dichotomized experience of “distress” or “no distress.” Additionally, this hypothesis-generating study suggests future directions for potential self-report measures to help clinicians identify cancer survivors’ trajectory to develop a more patient-centered survivorship care plan.
Genetically Engineered Herbicide-Resistant Crops and Herbicide-Resistant Weed Evolution in the United States
Authors: Kniss Andrew R.
Published: December 2017

Genetically engineered (GE) herbicide-resistant crops have been widely adopted by farmers in the United States and other countries around the world, and these crops have caused significant changes in herbicide use patterns. GE crops have been blamed for increased problems with herbicide-resistant weeds (colloquially called by the misnomer “superweeds”); however, there has been no rigorous analysis of herbicide use or herbicide-resistant weed evolution to quantify the impact of GE crops on herbicide resistance. Here, I analyze data from the International Survey of Herbicide Resistant Weeds and the USDA and demonstrate that adoption of GE corn varieties did not reduce herbicide diversity, and therefore likely did not increase selection pressure for herbicide-resistant weeds in that crop. Adoption of GE herbicide-resistant varieties substantially reduced herbicide diversity in cotton and soybean. Increased glyphosate use in cotton and soybean largely displaced herbicides that are more likely to select for herbicide-resistant weeds, which at least partially mitigated the impact of reduced herbicide diversity. The overall rate of newly confirmed herbicide-resistant weed species to all herbicide sites of action (SOAs) has slowed in the United States since 2005. Although the number of glyphosate-resistant weeds has increased since 1998, the evolution of new glyphosate-resistant weed species as a function of area sprayed has remained relatively low compared with several other commonly used herbicide SOAs.
Scientists Discover Stromboli-Like Eruption on Volcanic Moon
Authors: Wendel JoAnna
Published: December 2017

Jupiter’s moon Io is known for its lava fountains and roiling lava lakes, but scientists had never seen such an intense eruption in their data until now.
Replication-dependent size reduction precedes differentiation in Chlamydia trachomatis
Authors: Lee Jennifer K. , Enciso Germán A. , Boassa Daniela , Chander Christopher N. , Lou Tracy H. , Pairawan Sean S. , Guo Melody C. , Wan Frederic Y. M. , Ellisman Mark H. , Sütterlin Christine , Tan Ming
Published: December 2017

Chlamydiatrachomatis is the most common cause of bacterial sexually transmitted infection. It produces an unusual intracellular infection in which a vegetative form, called the reticulate body (RB), replicates and then converts into an elementary body (EB), which is the infectious form. Here we use quantitative three-dimensional electron microscopy (3D EM) to show that C. trachomatis RBs divide by binary fission and undergo a sixfold reduction in size as the population expands. Conversion only occurs after at least six rounds of replication, and correlates with smaller RB size. These results suggest that RBs only convert into EBs below a size threshold, reached by repeatedly dividing before doubling in size. A stochastic mathematical model shows how replication-dependent RB size reduction produces delayed and asynchronous conversion, which are hallmarks of the Chlamydia developmental cycle. Our findings support a model in which RB size controls the timing of RB-to-EB conversion without the need for an external signal.
Role of outer surface probes for regulating ion gating of nanochannels
Authors: Li Xinchun , Zhai Tianyou , Gao Pengcheng , Cheng Hongli , Hou Ruizuo , Lou Xiaoding , Xia Fan
Published: December 2017

Nanochannels with functional elements have shown promise for DNA sequencing, single-molecule sensing, and ion gating. Ionic current measurement is currently a benchmark, but is focused solely on the contribution from nanochannels’ inner-wall functional elements (NIWFE); the attributes of functional elements at nanochannels’ outer surface (NOSFE) are nearly ignored, and remain elusive. Here we show that the role of NOSFE and NIWFE for ion gating can be distinguished by constructing DNA architectures using dual-current readout. The established molecular switches have continuously tunable and reversible ion-gating ability. We find that NOSFE exhibits negligible ion-gating behavior, but it can produce a synergistic effect in alliance with NIWFE. Moreover, the high-efficiency gating systems display more noticeable synergistic effect than the low-efficiency ones. We also reveal that the probe amount of NOSFE and NIWFE is almost equally distributed in our biomimetic nanochannels, which is potentially a premise for the synergistic ion-gating phenomena.
Transient rotation of photospheric vector magnetic fields associated with a solar flare
Authors: Xu Yan , Cao Wenda , Ahn Kwangsu , Jing Ju , Liu Chang , Chae Jongchul , Huang Nengyi , Deng Na , Gary Dale E. , Wang Haimin
Published: December 2017

As one of the most violent eruptions on the Sun, flares are believed to be powered by magnetic reconnection. The fundamental physics involving the release, transfer, and deposition of energy have been studied extensively. Taking advantage of the unprecedented resolution provided by the 1.6 m Goode Solar Telescope, here, we show a sudden rotation of vector magnetic fields, about 12–20° counterclockwise, associated with a flare. Unlike the permanent changes reported previously, the azimuth-angle change is transient and cospatial/temporal with Hα emission. The measured azimuth angle becomes closer to that in potential fields suggesting untwist of flare loops. The magnetograms were obtained in the near infrared at 1.56 μm, which is minimally affected by flare emission and no intensity profile change was detected. We believe that these transient changes are real and discuss the possible explanations in which the high-energy electron beams or Alfve′n waves play a crucial role.
Thermoplastic–elastomer composition based on an interpenetrating polymeric network of styrene butadiene rubber–poly(methyl methacrylate) as an efficient vibrational damper
Authors: James Jose , Thomas George V. , P. Pramoda K. , Kalarikkal Nandakumar , Thomas Sabu
Published: December 2017

A new series of interpenetrating polymer networks (IPNs) and semi-IPNs based on styrene butadiene rubber (SBR) and poly[methyl methacrylate] (PMMA) have been synthesized by sequential polymerization.
Conjugate substitution and addition of α-substituted acrylate: a highly efficient, facile, convenient, and versatile approach to fabricate degradable polymers by dynamic covalent chemistry
Authors: Kohsaka Yasuhiro , Miyazaki Takumi , Hagiwara Keito
Published: December 2017

Degradable poly(conjugated ester)s with various backbones were synthesized via conjugate substitution (SN2′) polymerization of bis[α-(chloromethyl)acrylate] and nucleophilic monomers under ambient conditions.
Recent development of plasmon-mediated photocatalysts and their potential in selectivity regulation
Authors: Zhang Xingguang , Ke Xuebin , Yao Jianfeng
Published: December 2017

Solar energy for chemical production with high product selectivity under ambient conditions has attracted considerable attention.
Solution-processable, niobium-doped titanium oxide nanorods for application in low-voltage, large-area electronic devices
Authors: Alharthi F. A. , Cheng F. , Verrelli E. , Kemp N. T. , Lee A. F. , Isaacs M. A. , O’Neill M. , Kelly S. M.
Published: December 2017

Synthesis and characterization of surface-stabilised, niobium-doped titanium dioxide (Ni-TiO2) nanorods in a simple one-step reaction using oleic acid as both a stabilizer and solubilizing agent.
Inferring giant planets from ALMA millimeter continuum and line observations in (transition) disks
Authors: Facchini S. , Pinilla P. , van Dishoeck E. F. , de Juan Ovelar M.
Published: December 2017

Context. Radial gaps or cavities in the continuum emission in the IR-mm wavelength range are potential signatures of protoplanets embedded in their natal protoplanetary disk are. Hitherto, models have relied on the combination of mm continuum observations and near-infrared scattered light images to put constraints on the properties of embedded planets. Atacama Large Millimeter/submillimeter Array (ALMA) observations are now probing spatially resolved rotational line emission of CO and other chemical species. These observations can provide complementary information on the mechanism carving the gaps in dust and additional constraints on the purported planet mass.

Aims. We investigate whether the combination of ALMA continuum and CO line observations can constrain the presence and mass of planets embedded in protoplanetary disks.

Methods. We post-processed azimuthally averaged 2D hydrodynamical simulations of planet-disk models, in which the dust densities and grain size distributions are computed with a dust evolution code that considers radial drift, fragmentation, and growth. The simulations explored various planet masses (1 MJ ≤ Mp ≤ 15 MJ) and turbulent parameters (10−4 ≤ α ≤ 10−3). The outputs were then post-processed with the thermochemical code DALI, accounting for the radially and vertically varying dust properties. We obtained the gas and dust temperature structures, chemical abundances, and synthetic emission maps of both thermal continuum and CO rotational lines. This is the first study combining hydrodynamical simulations, dust evolution, full radiative transfer, and chemistry to predict gas emission of disks hosting massive planets.

Results. All radial intensity profiles of 12CO, 13CO, and C18O show a gap at the planet location. The ratio between the location of the gap as seen in CO and the peak in the mm continuum at the pressure maximum outside the orbit of the planet shows a clear dependence on planet mass and is independent of disk viscosity for the parameters explored in this paper. Because of the low dust density in the gaps, the dust and gas components can become thermally decoupled and the gas becomes colder than the dust. The gaps seen in CO are due to a combination of gas temperature dropping at the location of the planet and of the underlying surface density profile. Both effects need to be taken into account and disentangled when inferring gas surface densities from observed CO intensity profiles; otherwise, the gas surface density drop at the planet location can easily be overestimated. CO line ratios across the gap are able to quantify the gas temperature drop in the gaps in observed systems. Finally, a CO cavity not observed in any of the models, only CO gaps, indicating that one single massive planet is not able to explain the CO cavities observed in transition disks, at least without additional physical or chemical mechanisms.
Geometric Three-Dimensional End-to-Side Microvascular Anastomosis: A Simple and Reproducible Technique
Authors: Ooi Adrian , Butz Daniel , Fisher Sean , Collier Zachary , Gottlieb Lawrence
Published: December 2017

Background End-to-side (ETS) anastomoses are useful when preservation of distal vascularity is critical. The ideal ETS microanastomosis should maintain a wide aperture and have a smooth take-off point to minimize turbulence, vessel spasm, and thrombogenicity of the suture line. We have developed a unique, dependable, and reproducible geometric technique for ETS anastomoses, and analyze its efficacy in our series of patients.

Methods The geometric ETS technique involves creating a three-dimensional (3D) diamond-shaped defect on the recipient vessel wall, followed by a slit incision of the donor vessel to create a “spatula” fitting this defect. This technique removes sutures from the point of most turbulent blood flow while holding the recipient vessel open with a patch vesselplasty effect. We perform a retrospective review of a single surgeon's experience using this technique.

Results The geometric 3D ETS technique was used in 87 free flaps with a total of 102 ETS anastomoses in a wide range of cases including head and neck, trunk and genitourinary, and extremity reconstruction. Overall, free flap success rates were 98%.

Conclusions The geometric 3D ETS technique creates a wide anastomosis, minimizes turbulence-inducing thrombogenicity, and mechanically holds the recipient vessel open. It is reliable and reproducible, and when performed properly has been shown to have high rates of success in a large group of free tissue transfer patients.
AGE–RAGE Stress, Stressors, and Antistressors in Health and Disease
Authors: Mishra Manish , Prasad Kailash
Published: December 2017

Adverse effects of advanced glycation end-products (AGEs) on the tissues are through nonreceptor- and receptor-mediated mechanisms. In the receptor-mediated mechanism, interaction of AGEs with its cell-bound receptor of AGE (RAGE) increases generation of oxygen radicals, activates nuclear factor-kappa B, and increases expression and release of pro-inflammatory cytokines resulting in the cellular damage. The deleterious effects of AGE and AGE–RAGE interaction are coined as “AGE-RAGE stress.” The body is equipped with defense mechanisms to counteract the adverse effects of AGE and RAGE through endogenous enzymatic (glyoxalase 1, glyoxalase 2) and AGE receptor-mediated (AGER1, AGER2) degradation of AGE, and through elevation of soluble receptor of AGE (sRAGE). Exogenous defense mechanisms include reduction in consumption of AGE, prevention of AGE formation, and downregulation of RAGE expression. We have coined AGE and RAGE as “stressors” and the defense mechanisms as “anti-stressors.” AGE–RAGE stress is defined as a shift in the balance between stressors and antistressors in the favor of stressors. Measurements of stressors or antistressors alone would not assess AGE–RAGE stress. For true assessment of AGE–RAGE stress, the equation should include all the stressors and antistressors. The equation for AGE–RAGE stress, therefore, would be the ratio of AGE + RAGE/sRAGE + glyoxalase1 + glyoxalase 2 + AGER1 +AGER2. This is, however, not practical in patients. AGE–RAGE stress may be assessed simply by the ratio of AGE/sRAGE. A high ratio of AGE/sRAGE indicates a relative shift in stressors from antistressors, suggesting the presence of AGE–RAGE stress, resulting in tissue damage, initiation, and progression of the diseases and their complications.
A multi-particle crushing apparatus for studying rock fragmentation due to repeated impacts
Authors: Huang S. , Mohanty B. , Xia K.
Published: December 2017

Rock crushing is a common process in mining and related operations. Although a number of particle crushing tests have been proposed in the literature, most of them are concerned with single-particle crushing, i.e., a single rock sample is crushed in each test. Considering the realistic scenario in crushers where many fragments are involved, a laboratory crushing apparatus is developed in this study. This device consists of a Hopkinson pressure bar system and a piston-holder system. The Hopkinson pressure bar system is used to apply calibrated dynamic loads to the piston-holder system, and the piston-holder system is used to hold rock samples and to recover fragments for subsequent particle size analysis. The rock samples are subjected to three to seven impacts under three impact velocities (2.2, 3.8, and 5.0 m/s), with the feed size of the rock particle samples limited between 9.5 and 12.7 mm. Several key parameters are determined from this test, including particle size distribution parameters, impact velocity, loading pressure, and total work. The results show that the total work correlates well with resulting fragmentation size distribution, and the apparatus provides a useful tool for studying the mechanism of crushing, which further provides guidelines for the design of commercial crushers.
Thermal-electric modeling of graphite: Analysis of charge carrier densities and Joule heating of intrinsic graphite rods
Authors: Muñoz-Hernández Andrés , Diaz Gerardo , Calderón-Muñoz Williams R. , Leal-Quiros Edbertho
Published: December 2017

Graphite is a versatile material with many applications. Its intrinsic density has been extensively studied and quantified experimentally and theoretically. Experimental data suggest that the electron and hole densities are roughly equal, but the degree of inequality or the magnitude of the difference has not been quantified before for intrinsic graphite under biased (applied voltage) conditions. In this paper, a steady-state one-dimensional drift-diffusion thermal-electric model is developed to explore and analyze the nature of the electron, hole and intrinsic carrier densities of graphite rods under an externally applied voltage. The maximum difference between hole and electron densities as a function of length and applied voltage are numerically determined, showing that the maximum absolute difference between hole and electron densities decreases as the ratio of length over electric field increases. Moreover, it is observed that the difference between hole and electron densities varies with position. The model is further utilized for the analysis of the dependency of charge carrier transport, heat transport and temperature under a variety of operating conditions. The results show that higher applied voltages lead to higher current densities and higher current densities result in higher power generation by Joule heating, leading to higher lattice temperatures and voltage gradients along the length of the graphite rod. Dimensionless and scaling analysis showed that in the range of operating conditions, convective and radiation losses were negligible, with the lattice temperature increasing significantly when Joule heating was high.
Interface charge trapping induced flatband voltage shift during plasma-enhanced atomic layer deposition in through silicon via
Authors: Li Yunlong , Suhard Samuel , Van Huylenbroeck Stefaan , Meersschaut Johan , Van Besien Els , Stucchi Michele , Croes Kristof , Beyer Gerald , Beyne Eric
Published: December 2017

A Through Silicon Via (TSV) is a key component for 3D integrated circuit stacking technology, and the diameter of a TSV keeps scaling down to reduce the footprint in silicon. The TSV aspect ratio, defined as the TSV depth/diameter, tends to increase consequently. Starting from the aspect ratio of 10, to improve the TSV sidewall coverage and reduce the process thermal budget, the TSV dielectric liner deposition process has evolved from sub-atmospheric chemical vapour deposition to plasma-enhanced atomic layer deposition (PE-ALD). However, with this change, a strong negative shift in the flatband voltage is observed in the capacitance-voltage characteristic of the vertical metal-oxide-semiconductor (MOS) parasitic capacitor formed between the TSV copper metal and the p-Si substrate. And, no shift is present in planar MOS capacitors manufactured with the same PE-ALD oxide. By comparing the integration process of these two MOS capacitor structures, and by using Elastic Recoil Detection to study the elemental composition of our films, it is found that the origin of the negative flatband voltage shift is the positive charge trapping at the Si/SiO2 interface, due to the positive PE-ALD reactants confined to the narrow cavity of high aspect ratio TSVs. This interface charge trapping effect can be effectively mitigated by high temperature annealing. However, this is limited in the real process due to the high thermal budget. Further investigation on liner oxide process optimization is needed.
Effect of surface roughness on droplet splashing
Authors: Hao Jiguang
Published: December 2017

It is well known that rough surfaces trigger prompt splashing and suppress corona splashing on droplet impact. Upon water droplet impact, we experimentally found that a slightly rough substrate triggers corona splashing which is suppressed to prompt splashing by both further increase and further decrease of surface roughness. The nonmonotonic effect of surface roughness on corona splashing weakens with decreasing droplet surface tension. The threshold velocities for prompt splashing and corona splashing are quantified under different conditions including surface roughness, droplet diameter, and droplet surface tension. It is determined that slight roughness significantly enhances both prompt splashing and corona splashing of a water droplet, whereas it weakly affects low-surface-tension droplet splashing. Consistent with previous studies, high roughness triggers prompt splashing and suppresses corona splashing. Further experiments on droplet spreading propose that the mechanism of slight roughness enhancing water droplet splashing is due to the decrease of the wetted area with increasing surface roughness.
Preparation and characterization of SiO2-coated submicron-sized L1 Fe-Pt particles
Authors: Hayashi Yoshiaki , Ogawa Tomoyuki , Ishiyama Kazushi
Published: December 2017

The development of magnets with higher performance is attracting increasing interest. The optimization of their microstructure is essential to enhance their properties, and a microstructure comprising magnetically isolated hard magnetic grains of a single-domain size has been proposed as an ideal structure for enhancing the coercivity of magnets. To obtain magnets with an ideal structure, we consider the fabrication of magnets by an approach based on core/shell nanoparticles with a hard magnetic core and a non-magnetic shell. In this study, to obtain particles for our proposed approach, we attempted to fabricate L10 Fe-Pt/SiO2-core/shell particles with submicron-sized cores less than the critical single-domain size. The fabrication of such core/shell particles was confirmed from morphology observations and XRD analysis of the particles. Although the formation of more desirable core/shell particles with submicron-sized single-crystal cores in the single-domain size range was not achieved, the fabricated core/shell particles showed a high coercivity of 25 kOe.
Single crystal growth and anisotropic magnetic properties of HoAl2Ge2
Authors: Matin Md. , Mondal Rajib , Thamizhavel A. , Provino A. , Manfrinetti P. , Dhar S. K.
Published: December 2017

We have grown a single crystal of HoAl2Ge2, which crystallizes in the hexagonal CaAl2Si2 type structure with Ho ions in the trigonal coordination in the ab plane. The data obtained from the bulk measurement techniques of magnetization, heat capacity and transport reveal that HoAl2Ge2 orders antiferromagnetically at TN ∼6.5 K. The susceptibility below TN and isothermal magnetization at 2 K indicate the ab plane as the easy plane of magnetization. Heat capacity data reveal a prominent Schottky anomaly with a broad peak centered around 25 K, suggesting a relatively low crystal electric field (CEF) splitting. The electrical resistivity reveals the occurrence of a superzone gap below TN. The point charge model of the CEF is applied to the magnetization and the heat capacity data. While a good fit to the paramagnetic susceptibility is obtained, the CEF parameters do not provide a satisfactory fit to the isothermal magnetization at 2 K and the Schottky anomaly.
Enhanced and one-way absorptance of LiNiO2 thin films in one-dimensional photonic crystals
Authors: Yang C. H. , Zhang C. , Ao Z. M. , Wang G. X.
Published: December 2017

The refractive index of LiNiO2 thin films is complex and exhibits both dielectric and metallic properties. With LiNiO2 thin films coated on or inserted in photonic crystals (PCs), it is possible to enhance the absorptance in the designed (AB)nLiNiO2(BA)m PC structures. One-way absorption in the photonic bandgap of (AB) PCs has been observed via changing the optical transmitting direction. The positions, width, and strength of the absorption peaks depend on the thickness of the LiNiO2 films, the incident angles, and the transverse electric/transverse magnetic modes. The photonic band structure can be employed to determine the allowed and forbidden photonic modes and the related optical properties for (AB) PC and (AB)nLiNiO2 PCs. These novel absorption characteristics can enrich the optoelectric properties of LiNiO2 thin films.
Influence of capillary end effects on steady-state relative permeability estimates from direct pore-scale simulations
Authors: Guédon Gaël Raymond , Hyman Jeffrey De’Haven , Inzoli Fabio , Riva Monica , Guadagnini Alberto
Published: December 2017

We investigate and characterize the influence of capillary end effects on steady-state relative permeabilities obtained in pore-scale numerical simulations of two-phase flows. Our study is motivated by the observation that capillary end effects documented in two-phase laboratory-scale experiments can significantly influence permeability estimates. While numerical simulations of two-phase flows in reconstructed pore-spaces are increasingly employed to characterize relative permeabilities, a phenomenon which is akin to capillary end effects can also arise in such analyses due to the constraints applied at the boundaries of the computational domain. We profile the relative strength of these capillary end effects on the calculation of steady-state relative permeabilities obtained within randomly generated porous micro-structures using a finite volume-based two-phase flow solver. We suggest a procedure to estimate the extent of the regions influenced by these capillary end effects, which in turn allows for the alleviation of bias in the estimation of relative permeabilities.
Sustainable thermoelectric materials fabricated by using Cu2Sn1-xZnxS3 nanoparticles as building blocks
Authors: Zhou Wei , Shijimaya Chiko , Takahashi Mari , Miyata Masanobu , Mott Derrick , Koyano Mikio , Ohta Michihiro , Akatsuka Takeo , Ono Hironobu , Maenosono Shinya
Published: December 2017

Uniform Cu2Sn1-xZnxS3 (x = 0–0.2) nanoparticles (NPs) with a characteristic size of about 40 nm were chemically synthesized. The primary crystal phase of the NPs was wurtzite (WZ) with a mean crystalline size of about 20 nm. The NPs were sintered to form nanostructured pellets with different compositions preserving the composition and grain size of the original NPs by the pulse electric current sintering technique. The pellets had a zinc blende (ZB) structure with a residual WZ phase, and the mean crystalline size was found to remain virtually unchanged for all pellets. Among all samples, the pellets of Cu2Sn0.95Zn0.05S3 and Cu2Sn0.85Zn0.15S3 exhibited the highest ZT value (0.37 at 670 K) which is 10 times higher than that of a non-nanostructured Cu2SnS3 bulk crystal thanks to effective phonon scattering by nanograins, the phase-pure ZB crystal structure, and the increase in hole carrier density by Zn doping.
Experiments with arbitrary networks in time-multiplexed delay systems
Authors: Hart Joseph D. , Schmadel Don C. , Murphy Thomas E. , Roy Rajarshi
Published: December 2017

We report a new experimental approach using an optoelectronic feedback loop to investigate the dynamics of oscillators coupled on large complex networks with arbitrary topology. Our implementation is based on a single optoelectronic feedback loop with time delays. We use the space-time interpretation of systems with time delay to create large networks of coupled maps. Others have performed similar experiments using high-pass filters to implement the coupling; this restricts the network topology to the coupling of only a few nearest neighbors. In our experiment, the time delays and coupling are implemented on a field-programmable gate array, allowing the creation of networks with arbitrary coupling topology. This system has many advantages: the network nodes are truly identical, the network is easily reconfigurable, and the network dynamics occur at high speeds. We use this system to study cluster synchronization and chimera states in both small and large networks of different topologies.
Building the right centriole for each cell type
Authors: Loncarek Jadranka , Bettencourt-Dias Mónica
Published: December 2017

The centriole is a multifunctional structure that organizes centrosomes and cilia and is important for cell signaling, cell cycle progression, polarity, and motility. Defects in centriole number and structure are associated with human diseases including cancer and ciliopathies. Discovery of the centriole dates back to the 19th century. However, recent advances in genetic and biochemical tools, development of high-resolution microscopy, and identification of centriole components have accelerated our understanding of its assembly, function, evolution, and its role in human disease. The centriole is an evolutionarily conserved structure built from highly conserved proteins and is present in all branches of the eukaryotic tree of life. However, centriole number, size, and organization varies among different organisms and even cell types within a single organism, reflecting its cell type–specialized functions. In this review, we provide an overview of our current understanding of centriole biogenesis and how variations around the same theme generate alternatives for centriole formation and function.