bluuebunny/crossref_metadata_2025 huggingface dataset:
Combination therapy of omalizumab with house dust mite immunotherapy in chronic spontaneous urticaria associated with sensitization to dust mites-case series
Authors: Kathuria P C , Rai Manisha
Published: December 2021

Chronic spontaneous urticaria (CSU) is a heterogeneous disorder with recurrent pruritic wheals and/or angioedema. The anti-immunoglobulin E (omalizumab) is used in CSU patients resistant to four-fold second-generation anti-histamines. Most clinical trials have experienced relapse after stopping omalizumab treatment. Here, we present a case series of five cases of chronic atopic urticarial concomitant allergic rhinitis and asthma which have shown immunologically significant positivity to Dermatophagoides pteronyssinus and Dermatophagoides farinae. Disease control was achieved (Urticaria Activity Score 7 <6) in four cases by combination therapy of omalizumab with house dust mite (HDM) Allergen Immunotherapy (AIT) and remained sustained for three years on follow-up even after discontinuation of AIT for one year. We hypothesize that this combined therapy may contribute to enhanced clinical efficacy, safety, and faster achievement of disease control in CSU.
Fibrous dysplasia of maxilla – A rare case report
Authors: Kamble Vijaya R , Waghmare Shalini N , Rangari Aditi V , Meti Mangala , Pohankar Pritam , Paraye Swati
Published: December 2021

Fibrous dysplasia (FD) is a skeletal developmental anomaly, which is non-hereditary in origin and idiopathic in nature. It is a benign fibro-osseous disease that affects one or more bones. It usually affects unilaterally and is seen in the posterior region. Approximately 0.5% of untreated cases show the malignant transformation. We report the case of a 35-year-old female patient with FD involving the maxilla. The clinical diagnostic approach, different imaging modalities, and histological examination methods for definitive diagnosis have been elaborated.
Combatendo a COVID-19 através do fortalecimento do sistema imune com produtos naturais
Authors: Ghilosso-Bortolini Roberta , Olsen Priscilla Christina , Gilbert Benjamin
Published: December 2021

O sistema imune inato reconhece estruturas químicas dos vírus, ativando células capazes de bloquear a infecção viral, e ativa, também, o sistema imune adaptativo a desenvolver anticorpos que destroem ou imobilizam os vírus. De forma análoga, os componentes químicos de produtos naturais derivados de plantas e de leveduras podem agir como ativadores do sistema imune, ativando a defesa contra infecção viral. Neste trabalho, examinou-se diversos produtos naturais de alimentos e plantas medicinais, cujos componentes químicos, possivelmente, poderiam contribuir para a defesa contra SARS-CoV-2, o vírus que causa a COVID-19.
Avaliação da atividade antioxidante do extrato da Hibiscus sabdariffa L. para desenvolvimento de formulação cosmética
Authors: Sousa José Maria Aguiar , Caldas Jeanne Marques , Brito Maria Cristiane Aranha
Published: December 2021

Hibiscus sabdariffa L., pertence à família Malvaceae, possuindo caracteres antioxidantes de interesse da indústria farmacêutica. Este trabalho teve como objetivo desenvolver uma formulação cosmética a base do extrato de Hibiscus sabdariffa L., com destaque para sua atividade antioxidante. A metodologia deste material baseia-se na análise fitoquímica do extrato, avaliação da toxicidade frente à Artemia salina L. e, por fim, testes de estabilidade das formulações. Dentro dos principais resultados, os testes fitoquímicos demonstraram a presença de alcaloides, flavonoides e taninos, já no que diz respeito ao teor de polifenóis totais a média com maior teor foi a do hidromódulo 1:8 com 0,875 (mgGA)/g. O extrato encontrado com menor toxicidade foi o do hidromódulo 1:10 com o valor da CL50 encontrado de ±29270,3 µL/mL. A formulação mais estável foi a que possui uma concentração de creme aniônico tipo lanette® a 14% p/p em uma análise de 15 dias. Portanto, o hidromódulo 1:10 possui uma vantagem no que diz respeito a escolha para a produção da formulação farmacêutica contendo o extrato de Hibiscus sabdariffa, a julgar por sua menor toxicidade e sua capacidade como antioxidante.
Saber popular e conhecimento científico na comercialização de plantas medicinais para saúde bucal
Authors: Emmi Danielle Tupinambá , Melo Fernanda Oliveira Brelaz , Araújo Marizeli Viana de Aragão
Published: December 2021

O objetivo deste estudo foi investigar o perfil socioeconômico de erveiros, o conhecimento acerca dos produtos que comercializam e as principais ervas indicadas para afecções bucais. Foi realizado estudo de campo com visita à 22 feiras da cidade de Belém, Pará, Brasil. A amostra foi coletada por conveniência com 40 erveiros que trabalhavam no ramo, em período mínimo de 01 ano, que responderam um questionário semiestruturado. Os dados foram trabalhados de forma descritiva, utilizando os testes G e teste de Fisher para análise entre variáveis (α=0,05). A maioria dos erveiros é de mulheres (62,5%), que adquiriu conhecimento sobre ervas com os familiares (75%, p=0,17), nunca participou de cursos sobre o tema (70,0%, p=0,09), afirmou que existem ervas tóxicas (72,5%, p=0,72), mas que estas não apresentam contraindicações (90,0%, p=0,61). Entre as ervas mais recomendadas, foram citadas a semente do jucá (Libidibia férrea (Mart. ex Tul.) LPQueiroz (Fabaceae)) (70%) e a casca do cajuí (Anacardium occidentale) (25%). A venda das ervas medicinais para afecções bucais é uma prática comum, sendo que a comercialização ocorre, sobretudo, de forma empírica. Assim, há necessidade da capacitação dos erveiros, para associação do conhecimento tradicional ao científico, para que a população tenha acesso a produtos mais eficazes.
Uso domiciliar de plantas medicinais por usuários dos serviços das Unidades Básicas de Saúde do município de Toledo, Paraná
Authors: Alencar Queren Hapuque Oliveira , Oliveira Dagna Karen , Santos Mauricio Bedim dos , Manetti Camila Lopes , Guevara Fernanda Morinigo , Florência Gabriela Rodrigues Moreira , Silva Aline Daniel da , Buzin Gabrielle , Souza Luana Pacheco de , Souza Isaque Donizett Silva de , Andrade Sonia Mara , Ruths Jéssica Cristina , Teixeira Kádima Nayara
Published: December 2021

O uso empírico das plantas medicinais é uma prática mundialmente disseminada, cuja finalidade baseia-se no alívio/cura de algumas enfermidades. Objetivou-se caracterizar o perfil epidemiológico do uso domiciliar dessas plantas, pelos usuários de sete Unidades Básicas de Saúde com equipe Estratégia Saúde da Família, no município de Toledo/Paraná. Para tanto, foi aplicado um questionário a 324 pessoas. A análise dos dados mostrou que 89,50% dos entrevistados faziam uso de plantas medicinais, destes, 91,38% do sexo feminino, 42% com idade entre 21 e 40 anos, 30% sem concluir o ensino fundamental e 45,48% com renda per capita entre 01 a 03 salários mínimos. As folhas foram as partes das plantas mais utilizadas (45,10%), o modo de preparo predominante foi o chá em infusão (30,86%) e 83,64% tiveram o conhecimento de utilização das plantas repassado por familiares. Foram registradas 1.082 citações de 120 espécies de plantas, 50% destas não possuem registro na Denominação Comum Brasileira da Agência de Vigilância Sanitária; entre elas encontram-se espécies cujo conhecimento de senso comum é tão difundido que remete à incredulidade de ausência de estudos científicos para o fim citado, conferindo a falsa ideia de ausência de risco à saúde.
Rancangan Prototype Layanan Pengaduan Masyarakat Melalui Kantor Desa Berbasis Android
Authors: Yurindra Yurindra , Sarwindah Sarwindah , Irawan Devi
Published: December 2021

Salah satu Peningkatan kualitas pelayanan public bagi masyarakat pedesaan adalah dapat dengan dilakukan melalui sebuah penyelesaian pengaduan yang mendapatkan respon yang cepat dari penyedia layanan yaitu dalam hal ini instansi pemerintah terkait baik di pusat maupun daerah. Segala bentuk kritik, saran maupun aduan yang disampaikan masyarakat pada suatu instansi merupakan sebuah koreksi untuk perbaikan pelayanan tersebut. Banyak Kantor Desa di Indonesia belum memiliki sistem layanan pengaduan yang teridentifikasi dan terdokumentasi dengan baik, sehingga timbul kendala dalam memberikan layanan pengaduan kepada masyarakat, seperti respon time pelayanan yang lambat dan dokumentasi pengaduan tidak tertata dengan rapi. Kendala lain timbul saat masyarakat kebingungan untuk menyampaikan keluhan tersebut dikarenakan tidak mengetahui harus mengadu kemana. Untuk mengatasi masalah tersebut, akan dirancang aplikasi layanan pengaduan berbasis Android yang menggunakan model prototype dan menggunakan MySql sebagai database pada server yang digunakan. Dengan itu diharapkan agar dapat  memudahkan masyarakat dalam membuat laporan pengaduan. Aplikasi Android ini dapat digunakan masyarakat untuk melakukan layanan pengaduan secara online. Aplikasi ini juga dapat memudahkan Pemerintah desa dan kabupaten dalam melakukan dokumentasi dan mengevaluasi sistem layanan  pengaduan masyarakat desa.
Sistem Pendukung Keputusan Pemilihan Kepala Biro Menggunakan Metode Simple Additive Weighting (SAW)
Authors: Hamidah Hamidah , Rizan Okkita , Wahyuningsih Delpiah , Laurentinus Laurentinus
Published: December 2021

Biro merupakan bagian dari sebuah instansi baik pemerintah maupun swasta yang mengurus suatu pekerjaan. Setiap instansi pemerintah maupun swasta mempunyai beberapa biro. Masing-masing biro akan menangani pekerjaan yang berbeda-beda. Setiap biro dipimpin oleh seorang kepala biro dengan beberapa staf dibawahnya sehingga keberhasilan suatu biro menjadi tanggung jawab kepala biro. Untuk itu, permasalahan yang sering terjadi baik pada instansi pemerintah maupun swasta adalah masih kesulitan menentukan kepala biro yang layak menjabat amanah tersebut. Dengan banyaknya sumber daya manusia pada suatu instansi, maka instansi akan kesulitan memilih kepala biro. Untuk mengatasi permasalahan diatas, maka kami berusaha membantu pihak instansi dalam mengambil keputusan secara tepat dan cepat dengan cara menyiapkan sistem pendukung keputusan sehingga dapat membantu pihak instansi. Metode yang digunakan dalam penelitian ini adalah metode SAW (Simple Additive Weighting). Berdasarkan Hasil penelitian, maka diperoleh skor 0,975 oleh kandidat V4, skor 0,925 oleh kandidat V1, skor 0,8625 oleh kandidat V2 dan skor 0,8375 oleh kandidat V3 sehingga yang terpilih menjadi kepala biro adalah kandidat yang memperoleh skor tertinggi yaitu V4.
Perbandingan Klassifikasi SMS Berbasis Support Vector Machine, Naive Bayes Classifier, Random Forest dan Bagging Classifier
Authors: Irawan Devi , Perkasa Eza Budi , Yurindra Yurindra , Wahyuningsih Delpiah , Helmud Ellya
Published: December 2021

Short message service (SMS) adalah salah satu media komunikasi yang penting untuk mendukung kecepatan pengunaan ponsel oleh pengguna. Sistem hibrid klasifikasi SMS digunakan untuk mendeteksi sms yang dianggap sampah dan benar. Dalam penelitian ini yang diperlukan adalah mengumpulan dataset SMS, pemilihan fitur, prapemrosesan, pembuatan vektor, melakukan penyaringan dan pembaharuan sistem. Dua jenis klasifikasi SMS pada ponsel saat ini ada yang terdaftar sebagai daftar hitam (ditolak) dan daftar putih (diterima). Penelitian ini menggunakan beberapa algoritma seperti support vector machine, Naïve Bayes classifier, Random Forest dan Bagging Classifier. Tujuan dari penelitian ini adalah untuk menyelesaikan semua masalah SMS yang teridentifikasi spam yang banyak terjadi pada saat ini sehingga dapat memberikan masukan dalam perbandingan metode yang mampu menyaring dan memisahkan sms spam dan sms non spam.  Pada penelitian ini menghasilkan bahwa Bagging classifier algorithm ini mendapatkan ferformance score tertinggi dari algoritma yang lain yang dapat dipergunakan sebagai sarana untuk memfiltrasi SMS yang masuk ke dalam inbox pengguna dan Bagging classifier algorithm dapat memberikan hasil filtrasi yang akurat untuk menyaring SMS yang masuk.
O comportamento dos gestores operacionais da empresa Brasileira de correios e telégrafos: relato de experiência sobre a procrastinação na condução de processos administrativos disciplinares
Authors: Souza Fernanda Leobons de
Published: December 2021

O artigo trata-se de um relato de experiência sobre os principais padrões de comportamento, tais como: falta de comprometimento e falta de motivação, que levam grande parte dos líderes operacionais da Empresa Brasileira de Correios e Telégrafos (ECT) a postergar a conclusão dos PADs (Processos Administrativos Disciplinares), por entenderem que eles ajudam a promover um clima organizacional desfavorável, comprometendo, dessa forma, a relação entre o gestor e seus subordinados. Tendo em vista este cenário, foi levantada a seguinte questão norteadora: quais os principais padrões de comportamento dos gestores com relação a conclusão das PADs e por que eles acabam postergando a conclusão delas? O estudo tem como objetivo principal apresentar um relato de experiência sobre o comportamento dos gestores operacionais que trabalham na ECT, quanto à procrastinação na condução de processos administrativos disciplinares. Para tanto, através da metodologia de pesquisa bibliográfica e documental e, sobretudo, do relato de experiência na ECT, pretende-se apresentar no artigo, uma contextualização do que ocorre no âmbito da instituição e os fatores que implicam o atraso no saneamento de processos administrativos disciplinares autuados, por exemplo, em virtude do mau uso de smartphones por parte de seus funcionários. A autora do presente artigo trabalha na ECT há dezesseis anos, e participa desde o ano de 2020 da equipe responsável por oferecer suporte aos gestores da área operacional, quanto às dúvidas pertinentes à movimentação das PADs. Constatou-se que o SEI (Sistema Eletrônico de Informações) foi criado pelo Tribunal Regional Federal da 4ª Região, ente 2011 e 2013, e fornecido gratuitamente às instituições da administração pública, inclusive à ECT, como uma ferramenta eficaz para a gestão eletrônica dos documentos oficiais. O sistema em questão é utilizado para instauração e acompanhamento de processos administrativos, inclusive dos PADs que visam à identificação dos funcionários responsáveis pelas avarias e danos causados aos aparelhos com os quais os carteiros realizam a entrega dos objetos postais aos respectivos destinatários, gerando como consequências: a insatisfação dos clientes e eventuais prejuízos para a empresa.
The Role of Professional Standards in Regulating the Professional Activities of Healthcare Professionals
Authors:   Republican Center for Healthcare Development, Koikov Vitaliy
Published: December 2021

This review is devoted to the analysis of the existing shortcomings in the sectoral qualifications system and the development of suggestions for improving the mechanisms for regulating the professional activities of healthcare professionals in the Republic of Kazakhstan. The main problems in the development of human resources for health care that require a systemic solution include the lack of compliance of training programs and the system of continuous professional development of workers in the industry, a system for assessing professional readiness and admission of health professionals for practical activities to the needs of practical health care, the lack of a clear delineation of the competencies of health professionals by levels qualifications. The above problems are based on the imperfection of the Sectoral Qualifications System due to the absence of the Sectoral Qualifications Framework (covering all professions and professional activities in the health sector) and professional standards (regulating in detail for each qualification level all those labor functions and professional tasks that are necessary for those working in the industry. specialists, as well as the skills, knowledge, and even personal competencies required for this). The implementation of professional standards in the development of educational programs at all levels of education, in the activities of organizations that assess the professional readinesss of healthcare professionals, in the personnel policy of the health system, regions and medical organizations, will ensure that the competencies of graduates of educational programs and specialists working in the health sector correspond to the real needs of practical healthcare. All this will make it possible to achieve greater labor productivity of healthcare professionals, improve the quality of medical and other services provided, reduce the costs of recruiting and enhance the competitiveness of both specialists working in healthcare organizations
Improving the Rational Use of Medicines by Assessing Antibiotic Consumption to Solve the Problem of Antibiotic Resistance in the Republic of Kazakhstan
Authors:   Republican Center for Healthcare Development, Zhussupova Gulzira , Zhaldybayeva Saule ,   Republican Center for Healthcare Development, Skakova Aiym ,   Republican Center for Healthcare Development
Published: December 2021

The aim. Develop policy options to improve the rational use of medicines by assessing antibiotic consumption to address antibiotic resistance in the Republic of Kazakhstan. We used the data of the Republican Center for Healthcare Development’s report on the assessment of the consumption of antibiotics in the Republic of Kazakhstan, purchased by the Single Distributor within the guaranteed volume of free medical care for 2019, in comparison with the period 2017-2018. Three policy options have been developed: 1. Improving the rational prescription and use of antibacterial drugs. 2. Raising awareness and understanding of antimicrobial resistance issues through information policy and increased training 3. Strengthening control of prescription dispensing of antibacterial drugs in pharmacies. For each policy option, measures are identified to achieve them, as well as possible barriers. A combined implementation of each policy option is necessary, as this issue requires a systematic approach. The implementation of all points of measures will contribute to ensuring the use of antibacterials rationally, according to strict therapeutic indications, with an individual selection of dosages and will exclude self-medication with antibiotics, which in turn will help prevent antibiotic resistance in the future and will give a chance for effective, high-quality and successful treatment of bacterial infections. Key words: medicines, systemic antibiotics, consumption of antibiotics, antibiotic resistance, rational use of medicines, Kazakhstan.
Approaches to improve the effectiveness of social support measures provided to young professionals and graduates of medical education organizations. Policy Brief
Authors:   Republican Center for Healthcare Development, Umralin Timur , Bibolova Bagym ,   Republican Center for Healthcare Development, Malbekova Dinura ,   Republican Center for Healthcare Development, Omirkhan Zhansaya ,   Republican Center for Healthcare Development
Published: December 2021

What is the problem? • Imperfection of the regulatory legal framework for the provision of various measures of social support to young specialists, graduates of medical education and science organizations of the Republic of Kazakhstan and, accordingly, a low level of travel and employment of young specialists at the place of their personal distribution. • Lack of transparency and insufficient efficiency of the distribution mechanism and provided measures of social support for young specialists, university graduates at the republican and regional levels. • Low motivation and satisfaction of medical workers, including young professionals, arriving to work in rural areas of the Republic of Kazakhstan. Policy options Variant of politics 1. Perfection of normative legal base, qualificatory effective measures on social support of young specialists, graduating students of medical Institutions of higher learning. Variant of politics 2. Цифровизация and automation of distribution of young specialists, graduating students of organizations of education and science mechanism, and also the measures of social support rendered to them for an openness and transparency of process on the platform of www.enbek.kz. Variant of politics 3. Development and implementation of a separate section on employment and social support measures in the Concept for the Development of Rural Medicine, taking into account the existing domestic and international experience. Vision for implementing policy options. Estimating possibility of introduction of the offered variants of politics taking into account present barriers and possibilities, we come to the conclusion, that all three variants of politics complement each other. However, taking into account distinctions of variants in the orientation of actions, used resources and methods, more substantial achievement of aim of increase of efficiency of the measures of social support, rendered to the graduating students of organizations of medical education and science, these variants of politics can give during their сочетанной realization.
Some issues I have encountered on my path to becoming a psychoanalyst
Authors: Xiubing Wang
Published: December 2021

The author describes her personal journey in training and as a therapist. She explores the area of cultural difference and decides that the main cultural difference between now and her previous life is the advent of the new language of psycho-analysis. She explores the move to online treatment during the pandemic to arrive at a conclusion that the process of analytic therapy is paramount, overriding the superficial differences whether it is in-person or online.
FAILED INNOVATION IMPLEMENTATION IN TEACHER EDUCATION: A CASE ANALYSIS
Authors: Dobozy Eva
Published: December 2021

The global call for teacher quality improvement and numerous accounts of resistance to education reform at all levels of the education system brings to the forefront the tension between rhetoric and reality. This case study reports on a failed innovation attempt, which was based on the need for a signature pedagogy in Australian teacher education that better prepares beginning teachers for the demands of flexible, student-centred learning design. To assist teacher education students’ development of deep learning engagement, which is a pre-condition for the acquisition of 21st century knowledge, skills and learning attitudes, we need to better understand resistance behaviour. The reported reserach illustrates how the learning-centric teaching design was unable to engage ‘consumer students’ in deep learning experiences due to heightened negative emotion experienced by a great number of students. The provision of this illustrative practical example of innovation failure has the potential to make apparent how students’ ‘out-of-comfort-zone’ behaviour and resistance to change from transmission education practices to social constructivist approaches will need to be managed.
Key words: 21st century learning goals, inquiry-based learning, student resistance.
MULTICULTURAL COMPETENCE AND ITS DEVELOPMENT IN STUDENTS OF TEACHER EDUCATION CURRICULA
Authors: Džalalova Anna , Raud Nina
Published: December 2021

According to the Estonian State Integration Programme the system of education is considered to be one of the main areas of implementing the state integration policy. The main task of schools in Estonia is to support the feeling of belonging for permanent residents of the Estonian society by sharing common values and knowledge of the official language, and to create possibilities for understanding other cultures and establishing methods for cross-cultural communication with various ethnic groups.
The purpose of the research is to study multicultural competence which is considered to be a key component of professional teacher education, as it is of interdisciplinary nature and comprises various aspects which contribute to the development of cognition, personality and professional activities. The research, conducted among students into the level of development of their multicultural competence, has revealed that Narva College students have a positive ethnic identity and quite a high degree of tolerance, which testifies to the positive attitude to their own and other cultures and students’ readiness for intercultural communication.
To support the development of multicultural competence in students there has been devised a programme based on such educational components as the comprehensive knowledge of research methods and practices in multicultural education; formation of positive respectful attitude towards native and other cultures; development of skills to support culture-centred education and effective cross-cultural communication; and with inclusion of professional pedagogical activities being based on the humanistic approach and efficient pedagogical interaction.
The research covers key points of how the principles of multilingual and multicultural education are realised in everyday teaching practices to achieve corresponding learning outcomes.
Key words: multicultural competence, multicultural educational environment, principles of multicultural education, teacher education.
A Qualitative-Exploratory Pilot Study To Explore Students’ Perception On Experience And Multiple Intelligences’ Impact On Their Linguistic & Personal Growth
Authors: Acocella Rocco
Published: December 2021

Since learning represents one of the most relevant aspects of a humans’ life on which many researches have been conducted, nowadays more than ever it is essential exploring forward-looking theories, achieving inspiring improvements and making an action towards innovation within the educational systems. The qualitative-explorative pilot case study at issue aims to investigate a potential connection between Experience and Multiple Intelligences in relation to the linguistic and personal learning process. Specifically, its main goal is to draw a better understanding of students’ perception on the impact of past living-studying experiences and multidimensional teaching techniques on their linguistic and personal growth. To further investigate these objectives, there have been analysed 33 qualitative feedback from academical students studying languages collected through an inductive reasoning-based online survey structured as written interview and composed by closed-ended multiple choice questions, open-ended questions and ranking questions. The major findings claim that both living and studying abroad contributes to acquire metalinguistic awareness, to improve language skills and to develop life-long skills. Additionally, students recognised the implementation of Multiple Intelligence as an effective alternative to lectures as language teaching-learning strategy thanks to its flexibility and openness towards skills diversity.
Riscos na arrematação de imóvel residencial em leilão
Authors: Zavoiski Vanessa , Sales Caroline Samara Garcia , Guarise Marinei
Published: December 2021

No presente contexto, a procura por imóveis com preço abaixo do valor de mercado, tem tornado o leilão judicial uma opção atrativa para a aquisição de bens. Nesse sentido, este artigo visa demonstrar de forma sucinta quais são os riscos mais comuns que o arrematante terá ao adquirir um imóvel residencial por meio de leilão judicial. O assunto tem amplo panorama jurídico e múltiplas regras administrativas, que ao arrematante é de suma importância sua análise, planejamento e conhecimento prévio. A grande maioria dos imóveis leiloados está ocupado, seja com o proprietário, inquilinos, terceiros ou invasores. Esse cenário gera de imediato uma preocupação aos compradores, pois muitas vezes, os direitos do arrematante são desconhecidos.  A presente pesquisa apresenta uma explicação do funcionamento dos leilões e análise dos fatores que devem ser previamente analisados e verificados antes da arrematação. Por meio dos achados evidenciados na pesquisa possível observarem que o conteúdo apresentado não esgota o tema, pois diversidade da interpretação e entendimento do judiciário é particular de cada processo, conforme evidenciado pelos entrevistados. Por meio do presente estudo pode-se concluir que o apesar de o leilão judicial ter se tornado uma forma acessível de aquisição imobiliária, entretanto, nem sempre o desembaraço do bem trâmita de forma rápida e tranquila.
Gênese Instrumental a partir das metodologias rotação por estações e instrução por pares: um relato de experiência no programa PARFOR
Authors: Feitosa Francisco Eteval da Silva
Published: December 2021

O objetivo deste trabalho é relatar uma experiência didática com metodologias ativas em um curso de formação de professores de matemática no Plano Nacional de Formação de Professores da Educação Básica (PARFOR). O trabalho foi desenvolvido em dois encontros com 20 professores em formação no município de Itacoatiara, interior do Amazonas. As metodologias ativas abordadas foram o modelo de ensino híbrido rotação por estações e a instrução por pares. O referencial teórico subjacente é a Abordagem Instrumental de Pierre Rabardel, com foco na Gênese Instrumental, que estuda a transformação de um artefato em instrumento. Para o percurso metodológico, apoiamo-nos na construção de uma sequência didática inspirada nos princípios das próprias metodologias. A investigação, de cunho qualitativo e delineamento de uma pesquisa ação, teve como instrumentos a observação direta, aplicação de questionários com perguntas abertas e fechadas e com registros fotográficos de cada etapa da atividade. Os resultados alcançados nos permitiram concluir que, apesar de algumas dificuldades com conceitos matemáticos abordados, os professores participaram ativamente das atividades promovendo amplos debates com seus pares e mostraram-se bastante empenhados no aprendizado do conteúdo e dispostos a integrar tais metodologias na sua prática docente. Verificou-se ainda que a maioria dos professores conseguiu alcançar o processo de instrumentalização e que o ambiente dinâmico propiciado pelas metodologias ativas colaborou para a instrumentação.
Adaptação dos estudantes universitários em tempo de pandemia enquanto isolamento social
Authors: Chiusoli Cláudio Luiz , Dias Julie Cristini , Costa Lucas da , Serbai Lucas
Published: December 2021

O objetivo do estudo foi analisar o comportamento de consumo, hábito e atitudes dos estudantes universitários durante o lockdown em relação a pandemia da COVID-19. Considera-se um estudo exploratório e quantitativo. Quanto a amostragem, foi utilizada a não-probabilística por conveniência em um total de 100 entrevistas, em uma instituição pública e privada em uma cidade do interior do Paraná. Os principais achados foi que entre os entrevistados, 90,4% concordam que é importante conhecer o procedimento de higienização dos produtos alimentícios; 85,6% concordam que uma empresa que oferece delivery faz com que comprem mais; 75,0% perceberam que com o isolamento as propagandas de produtos aumentaram; 70,2% procuram sempre comprar marcas adquiridas anteriormente; 72,1% concordam que passaram a comprar menos em lojas físicas, e que por outro lado 64,4% passaram a comprar mais em lojas on line. Cerca de 42,3% concordam que durante a pandemia, a confiabilidade quanto a higiene de lanchonetes/fastfood diminuiu e apenas 25% concordam que com isolamento social compras de bens não-essenciais estão mais frequentes. Foi identificado que as compras on line aumentaram devido ao cenário atual, que não deixaram de comprar, mas sim migraram mais para compras on line pela facilidade e praticidade, fazendo assim que o comércio eletrônico continue com seu fluxo de venda de produtos e demonstraram ainda que se preocupam com a higiene e qualidade dos produtos alimentícios quando adquiridos.
Estudo da doença sarcopênica em indivíduos adultos com sobrepeso e obesidade
Authors: Dias Cleison Bonfim , Santana Júnior Virgílio
Published: December 2021

Este trabalho visa trazer dados sobre o estudo da doença sarcopênica, sobre a obesidade e sobre a obesidade sarcopênica, tendo como objetivo avaliar a presença da sarcopenia em indivíduos adultos com sobrepeso ou obesidade. Trata-se de um estudo transversal e analítico de abordagem quantitativa em 100 indivíduos adultos (50 obesos e 50 sobrepesos), entre 18 e 60 anos de idade. Os estudos foram realizados em uma clínica particular na cidade de Vitória da Conquista – BA. Contudo, ao findar das aplicações dos questionários e coletar os dados dos indivíduos, esses foram tabulados e receberam tratamento estatístico descritivo e analítico. A amostra apresentou predominância do sexo feminino tanto em sobrepesos quanto para obesos, não havendo diferença estatística significante entre os grupos para o sexo. Mesmo com as limitações da pesquisa, foi possível atingir os objetivos e trazer resultados concretos que indivíduos jovens com padrão de sobrepeso ou obesidade podem e apresentam sarcopenia. Ainda sugere-se a realização de novos estudos afim de abordar mais evidências científicas em indivíduos obesos e sobrepesos com sarcopenia.
Bioethical analysis of sanitary engineering: a critical assessment of the profession at the crossroads of environmental and public health ethics
Authors: Eterović I , Buterin T
Published: December 2021

Sanitary engineering is burdened by several challenges that attract bioethical attention: (1) there are many ambiguities regarding the definition of the profession; (2) its methodology seems to be a combination of several approaches from different sciences; and (3) it often appears to be an amalgam of different disciplines. We argue that the bioethical perspective helps to show that these features can be taken as a stimulating challenge. Moreover, bioethics may illuminate how these features can become an asset to sanitary engineering in light of the growing need for holistic approaches. First, we present a bioethical analysis of the aforementioned features as a useful way to clarify and strengthen the identity of the profession. Second, we argue that professional ethics have received the least attention, but are crucial to giving the profession stronger independence and professional identity and to creating a unique worldview at the crossroads of environmental and public health ethics. Finally, we propose a general framework of sound professional ethics of sanitary engineering as a necessary step towards rethinking the core values of the profession, clearly articulating a genuine professional ethic, and reforming educational politics related to professional education.
Singularities of surface mixing activity in the Western Mediterranean influence bluefin tuna larval habitats
Authors: Díaz-Barroso L , Hernández-Carrasco I , Orfila A , Reglero P , Balbín R , Hidalgo M , Tintoré J , Alemany F , Alvarez-Berastegui D
Published: December 2021

Understanding how the surface dynamics of the ocean influence the spawning and larval ecology of many large pelagic species, in particular tuna species, is a major challenge. For temperate tunas, the selection of geographically restricted spawning grounds is influenced by environmental conditions, but the influence of surface mixing properties on the early life stages of these species remains poorly understood. Here, based on ichthyoplankton samples collected over 4 yr and satellite-derived finite size Lyapunov exponents (FSLEs), we examined how horizontal mixing activity drives the probability of presence of Atlantic bluefin tuna Thunnus thynnus larvae. We further analyzed the spatial and temporal scales of the FSLE variability at which the relationship between larval presence and mesoscale activity is maximized. We found that moderate mixing activity strongly favors the spatial-temporal distribution of larval habitats, evidencing an optimal environmental window of bluefin tuna spawning and early life development within the mesoscale dynamics. During the spawning season, the Balearic Sea presents a unique spatial and temporal hydrodynamic scenario within the Western Mediterranean. These results can be used for developing oceanographic indicators and improving larval abundance indices that are currently used in Atlantic bluefin tuna stock assessments.
Turopoljske utvrde
Authors: Latinčić Dubravka , Regan Krešimir
Published: December 2021

U radu se razmatraju obrambeni kompleksi i građevine koji su tijekom razvijenoga te mahom kasnoga srednjega vijeka i početkom novoga vijeka izgrađeni na području Turopolja, povijesno-geografske regije između desne obale rijeke Save na sjeveroistoku, sisačke Posavine na jugoistoku, Pokuplja na jugu, Vukomeričkih gorica na jugozapadu te približno samoborsko-žumberačke regije na sjeverozapadu. Iako povijesni izvori svjedoče o više desetaka utvrda, u radu smo se osvrnuli samo
na one utvrde koje su u cijelosti ili u ruševinama sačuvane na terenu, kao i na one čiji izgled možemo rekonstruirati na osnovi starih crteža ili fotografija. Većina utvrda očuvana je tek u arheološkim slojevima, a prepoznaje se tek u promjenama u konfiguraciji terena. Iznimka je Lukavec, koji je ujedno i jedina u cijelosti sačuvana utvrda na čitavom promatranom prostoru, premda je u baroknom i klasicističkom razdoblju temeljito pregrađen u dvorac.
The Representation of Mental Illness in The Movie “Ma”
Authors: F Sarni , Muarifuddin Muarifuddin , Gultom Eva
Published: December 2021

Ma is a 2019 Psychological Horror movie that was directed by Tate Taylor and produced by Universal Pictures which was released in 2019. This study focuses on the main character. The objective of the study is to explain the representation of Carl Gustav Jung’s Psychoanalysis in the movie Ma. The data used the descriptive qualitative method. Carl Gustav Jung’s Psychoanalysis was used as a tool of analysis to explain the findings. The result in this study concerns Ma’s personality upbringing, she utilizes her persona to mislead the teenagers into fulfilling her desires to get her revenge on her old friends. Sue Ann's shadow gets her into a dark place in her life. She tortured the teenagers and killed Ben and Mercedes without acknowledging her bad behavior. She does not show empathy to her victims.
Desenvolvimento e Construção do Sistema de Baquetas para Pequenos Instrumentos Suspensos - SIBAPIS2020
Authors: Chaib Fernando , Morais Ronan , Leandro Charles , Silva Leandro , Silva Tiago
Published: December 2021

Observando obras diversas referente ao repertório percussivo (quer seja a solo, de câmara ou até mesmo sinfônica) percebemos que, em muitos casos, a impossibilidade de troca de baquetas em certos trechos musicais que envolvem montagens de percussão múltipla compromete a sonoridade de determinados instrumentos. Ao realizarmos um estudo sobre patentes e marcas registradas a respeito de sistemas de baquetas que permitem tocar pequenos instrumentos suspensos sem a necessidade de segurar os instrumentos e suas baquetas específicas, foi possível vislumbrarmos melhorias e ideias inovadoras para esse tipo de performance. Utilizando softwares licenciados para projetos em 3D, desenvolvemos e construímos o Sistema de Baquetas para Pequenos Instrumentos Suspensos - SIBAPIS2020. Tratando-se de um sistema com funcionalidades melhoradas e ampliadas em relação ao já existente no mercado, pretendemos contribuir para o melhoramento da performance percussiva, particularmente no contexto de pequenos instrumentos inseridos em montagens de percussão múltipla.
Рецензия на кол. мон.: Этнокультурные процессы Западного Полесья (Брестчины) в прошлом и настоящем. Минск: Беларуская навука, 2020. 621 с.
Authors: Григорьева Р.А.
Published: December 2021

Рецензируемая монография ”Этнокультурные процессы Западного Полесья (Бресчины)» посвящена исследованию региональных особенностей одного из шести историко-этнографических регионов Беларуси, который имеет ярко выраженные этнические, лингвистические и этнокультурные особенности. В работе представлен широкий круг вопросов – этническая история, особенности расселения, этноконфессиональная и этносоциальная структура, демографические процессы и семейно-брачные отношения, календарные праздники, особенности материальной культуры. Привлечение многочисленных источников позволили авторам прийти к выводу, что население Западного Полесья представляет собой специфическую этнографическую группу со своеобразной языковой и этноконфессиональной ситуацией и уникальным культурным ландшафтом.
The Development Tendency of 3D-Printed Bioceramic Scaffolds for Applications Ranging From Bone Tissue Regeneration to Bone Tumor Therapy
Authors: Fang Zhixiang , Chen Jihang , Pan Jiangxia , Liu Guoqiang , Zhao Chen
Published: December 2021

Three-dimensional (3D) printing concept has been successfully employed in regenerative medicine to achieve individualized therapy due to its benefit of a rapid, accurate, and predictable production process. Traditional biocomposites scaffolds (SCF) are primarily utilised for bone tissue engineering; nevertheless, over the last few years, there has already been a dramatic shift in the applications of bioceramic (BCR) SCF. As a direct consequence, this study focused on the structural, degeneration, permeation, and physiological activity of 3D-printed BCR (3DP-B) SCF with various conformations and work systems (macros, micros, and nanos ranges), as well as their impacts on the mechanical, degeneration, porosity, and physiological activities. In addition, 3DP-B SCF are highlighted in this study for potential uses applied from bone tissue engineering (BTE) to bone tumor treatment. The study focused on significant advances in practical 3DP-B SCF that can be utilized for tumor treatment as well as bone tissue regeneration (BTR). Given the difficulties in treating bone tumors, these operational BCR SCF offer a lot of promise in mending bone defects caused by surgery and killing any remaining tumor cells to accomplish bone tumor treatment. Furthermore, a quick assessment of future developments in this subject was presented. The study not only summarizes recent advances in BCR engineering, but it also proposes a new therapeutic strategy focused on the extension of conventional ceramics’ multifunction to a particular diagnosis.
Novel Trypanocidal Inhibitors that Block Glycosome Biogenesis by Targeting PEX3–PEX19 Interaction
Authors: Li Mengqiao , Gaussmann Stefan , Tippler Bettina , Ott Julia , Popowicz Grzegorz M , Schliebs Wolfgang , Sattler Michael , Erdmann Ralf , Kalel Vishal C
Published: December 2021

Human pathogenic trypanosomatid parasites harbor a unique form of peroxisomes termed glycosomes that are essential for parasite viability. We and others previously identified and characterized the essential Trypanosoma brucei ortholog TbPEX3, which is the membrane-docking factor for the cytosolic receptor PEX19 bound to the glycosomal membrane proteins. Knockdown of TbPEX3 expression leads to mislocalization of glycosomal membrane and matrix proteins, and subsequent cell death. As an early step in glycosome biogenesis, the PEX3–PEX19 interaction is an attractive drug target. We established a high-throughput assay for TbPEX3–TbPEX19 interaction and screened a compound library for small-molecule inhibitors. Hits from the screen were further validated using an in vitro ELISA assay. We identified three compounds, which exhibit significant trypanocidal activity but show no apparent toxicity to human cells. Furthermore, we show that these compounds lead to mislocalization of glycosomal proteins, which is toxic to the trypanosomes. Moreover, NMR-based experiments indicate that the inhibitors bind to PEX3. The inhibitors interfering with glycosomal biogenesis by targeting the TbPEX3–TbPEX19 interaction serve as starting points for further optimization and anti-trypanosomal drug development.
Biological Functions and Therapeutic Potential of Autophagy in Spinal Cord Injury
Authors: Liao Hai-Yang , Wang Zhi-Qiang , Ran Rui , Zhou Kai-Sheng , Ma Chun-Wei , Zhang Hai-Hong
Published: December 2021

Autophagy is an evolutionarily conserved lysosomal degradation pathway that maintains metabolism and homeostasis by eliminating protein aggregates and damaged organelles. Many studies have reported that autophagy plays an important role in spinal cord injury (SCI). However, the spatiotemporal patterns of autophagy activation after traumatic SCI are contradictory. Most studies show that the activation of autophagy and inhibition of apoptosis have neuroprotective effects on traumatic SCI. However, reports demonstrate that autophagy is strongly associated with distal neuronal death and the impaired functional recovery following traumatic SCI. This article introduces SCI pathophysiology, the physiology and mechanism of autophagy, and our current review on its role in traumatic SCI. We also discuss the interaction between autophagy and apoptosis and the therapeutic effect of activating or inhibiting autophagy in promoting functional recovery. Thus, we aim to provide a theoretical basis for the biological therapy of SCI.
RNA m6A Modification in Immunocytes and DNA Repair: The Biological Functions and Prospects in Clinical Application
Authors: Zhou Mingjie , Liu Wei , Zhang Jieyan , Sun Nan
Published: December 2021

As the most prevalent internal modification in mRNA, N6-methyladenosine (m6A) plays broad biological functions via fine-tuning gene expression at the post-transcription level. Such modifications are deposited by methyltransferases (i.e., m6A Writers), removed by demethylases (i.e., m6A Erasers), and recognized by m6A binding proteins (i.e., m6A Readers). The m6A decorations regulate the stability, splicing, translocation, and translation efficiency of mRNAs, and exert crucial effects on proliferation, differentiation, and immunologic functions of immunocytes, such as T lymphocyte, B lymphocyte, dendritic cell (DC), and macrophage. Recent studies have revealed the association of dysregulated m6A modification machinery with various types of diseases, including AIDS, cancer, autoimmune disease, and atherosclerosis. Given the crucial roles of m6A modification in activating immunocytes and promoting DNA repair in cells under physiological or pathological states, targeting dysregulated m6A machinery holds therapeutic potential in clinical application. Here, we summarize the biological functions of m6A machinery in immunocytes and the potential clinical applications via targeting m6A machinery.
The Role of Sorting Nexin 17 in Cardiac Development
Authors: Wu Yufei , Zhou Yaqun , Huang Jian , Ma Ke , Yuan Tianyou , Jiang Yong , Ye Maoqing , Li Jun
Published: December 2021

Sorting nexin 17 (SNX17), a member of sorting nexin (SNX) family, acts as a modulator for endocytic recycling of membrane proteins. Results from our previous study demonstrated the embryonic lethality of homozygous defect of SNX17. In this study, we investigated the role of SNX17 in rat fetal development. Specifically, we analyzed patterns of SNX17 messenger RNA (mRNA) expression in multiple rat tissues and found high expression in the cardiac outflow tract (OFT). This expression was gradually elevated during the cardiac OFT morphogenesis. Homozygous deletion of the SNX17 gene in rats resulted in mid-gestational embryonic lethality, which was accompanied by congenital heart defects, including the double-outlet right ventricle and atrioventricular and ventricular septal defects, whereas heterozygotes exhibited normal fetal development. Moreover, we found normal migration distance and the number of cardiac neural crest cells during the OFT morphogenesis. Although cellular proliferation in the cardiac OFT endocardial cushion was not affected, cellular apoptosis was significantly suppressed. Transcriptomic profiles and quantitative real-time PCR data in the cardiac OFT showed that SNX17 deletion resulted in abnormal expression of genes associated with cardiac development. Overall, these findings suggest that SNX17 plays a crucial role in cardiac development.