bluuebunny/crossref_metadata_2025 huggingface dataset:
Fermionic pole-skipping in holography
Authors: Čeplak Nejc , Ramdial Kushala , Vegh David
Published: July 2020

Abstract

We examine thermal Green’s functions of fermionic operators in quantum field theories with gravity duals. The calculations are performed on the gravity side using ingoing Eddington-Finkelstein coordinates. We find that at negative imaginary Matsubara frequencies and special values of the wavenumber, there are multiple solutions to the bulk equations of motion that are ingoing at the horizon and thus the boundary Green’s function is not uniquely defined. At these points in Fourier space a line of poles and a line of zeros of the correlator intersect. We analyze these ‘pole-skipping’ points in three-dimensional asymptotically anti-de Sitter spacetimes where exact Green’s functions are known. We then generalize the procedure to higher-dimensional spacetimes and derive the generic form the boundary correlator takes near the pole-skipping points in momentum space. We also discuss the special case of a fermion with half-integer mass in the BTZ background. We discuss the implications and possible generalizations of the results.
Runtime enforcement of timed properties usinggames
Authors: Renard Matthieu , Rollet Antoine , Falcone Yliès
Published: July 2020

This paper deals with runtime enforcement of timed properties with uncontrollable events. Runtime enforcement consists in defining and using an enforcement mechanism that modifies the executions of a running system to ensure their correctness with respect to the desired property. Uncontrollable events cannot be modified by the enforcement mechanisms and thus have to be released immediately. We present a complete theoretical framework for synthesising such mechanism, modelling the runtime enforcement problem as a Büchi game. It permits to pre-compute the decisions of the enforcement mechanism, thus avoiding to explore the whole execution tree at runtime. The obtained enforcement mechanism is sound, compliant and optimal, meaning that it should output as soon as possible correct executions that are as close as possible to the input execution. This framework takes as input any timed regular property modelled by a timed automaton. We present GREP, a tool implementing this approach. We provide algorithms and implementation details of the different modules of GREP, and evaluate its performance. The results are compared with another state of the art runtime enforcement tool.
Chemoenzymatic synthesis of daptomycin analogs active against daptomycin-resistant strains
Authors: Scull Erin M. , Bandari Chandrasekhar , Johnson Bryce P. , Gardner Eric D. , Tonelli Marco , You Jianlan , Cichewicz Robert H. , Singh Shanteri
Published: July 2020

Daptomycin is a last resort antibiotic for the treatment of infections caused by many Gram-positive bacterial strains, including vancomycin-resistant Enterococcus (VRE) and methicillin- and vancomycin-resistant Staphylococcus aureus (MRSA and VRSA). However, the emergence of daptomycin-resistant strains of S. aureus and Enterococcus in recent years has renewed interest in synthesizing daptomycin analogs to overcome resistance mechanisms. Within this context, three aromatic prenyltransferases have been shown to accept daptomycin as a substrate, and the resulting prenylated analog was shown to be more potent against Gram-positive strains than the parent compound. Consequently, utilizing prenyltransferases to derivatize daptomycin offered an attractive alternative to traditional synthetic approaches, especially given the molecule’s structural complexity. Herein, we report exploiting the ability of prenyltransferase CdpNPT to synthesize alkyl-diversified daptomycin analogs in combination with a library of synthetic non-native alkyl-pyrophosphates. The results revealed that CdpNPT can transfer a variety of alkyl groups onto daptomycin’s tryptophan residue using the corresponding alkyl-pyrophosphates, while subsequent scaled-up reactions suggested that the enzyme can alkylate the N1, C2, C5, and C6 positions of the indole ring. In vitro antibacterial activity assays using 16 daptomycin analogs revealed that some of the analogs displayed 2–80-fold improvements in potency against MRSA, VRE, and daptomycin-resistant strains of S. aureus and Enterococcus faecalis. Thus, along with the new potent analogs, these findings have established that the regio-chemistry of alkyl substitution on the tryptophan residue can modulate daptomycin’s potency. With additional protein engineering to improve the regio-selectivity, the described method has the potential to become a powerful tool for diversifying complex indole-containing molecules.

Key points

• CdpNPT displays impressive donor promiscuity with daptomycin as the acceptor.

• CdpNPT catalyzes N1-, C2-, C5-, and C6-alkylation on daptomycin’s tryptophan residue.

• Differential alkylation of daptomycin’s tryptophan residue modulates its activity.
Wettability, water absorption and water storage in rosette leaves of the dragon tree (Dracaena draco L.)
Authors: Jura-Morawiec Joanna , Marcinkiewicz Jan
Published: July 2020

Main conclusion

Leaf surfaces of Dracaena draco are wettable and can absorb water. The thick, basal leaf part could act as a water reservoir that changes in volume with plant hydration.

Rosettes of leaves of Dracaena draco play an important role in directing fog water through leaf axils into the stem tissues, where it can be stored for further use. However, how water is intercepted and collected by the leaves remains unclear, especially since leaf blade surfaces are considered hydrophobic. Based on the observations of D. draco individuals growing in Spain and in glasshouse conditions in Poland, we hypothesised that their long leaves (~ 70 cm) are able to absorb water along the whole leaf blade, but leaf age affects this process. We used water droplet contact angle measurements, anatomical analyses of leaf cross sections along the age gradient and dye tracer experiments to test this hypothesis. The data showed that the leaf surfaces of D. draco are wettable. In general, the mature leaves of the rosette are more wettable than the young ones. Water can be absorbed both through the adaxial and abaxial surfaces. The hydrenchyma is not uniformly distributed along the leaf, it is especially abundant towards the leaf base where it forms a massive water reservoir, which changes in volume depending on plant water status. The results of these studies shed light on the role of rosettes in water absorption by D. draco, and broaden our understanding of the functioning of this vulnerable species.
Kidney outcomes for children with lupus nephritis
Authors: Oni Louise , Wright Rachael D , Marks Stephen , Beresford Michael W , Tullus Kjell
Published: July 2020

Systemic lupus erythematosus is a rare lifelong multi-systemic autoimmune condition. Juvenile-onset SLE (JSLE) is recognized to have a more active disease course when compared with adult-onset disease and patients have a worse long-term survival. Kidney involvement occurs in over 50% of children and treatment decisions are guided by the histological classification. Several international groups have produced treatment protocols that rely on an intense period of immunosuppression to halt the acute kidney inflammatory process, followed by maintenance therapy with close observation for disease improvement and prompt evaluation of disease flares. A reduced glomerular filtration rate at presentation is predictive of later stage chronic kidney disease (CKD) in multivariate analysis. Kidney remission remains suboptimal with only 40–60% of patients achieving complete remission. Kidney flares are seen in over a third of patients. The rate of CKD 5 is reported to be up to 15% and the presence of lupus nephritis (LN) has an established link with an associated increase in mortality. In established kidney failure, transplantation seems to be the optimal kidney replacement modality for this group of patients, ideally after a period of disease quiescence. Modified outcome measures in clinical trials have demonstrated that biologic agents can be effective in this disease. Current biologic agents under investigation include obinutuzimab, belimumab, atacicept, anifrolumab, tocilizumab, eculizumab, dapirolizumab, and abatacept. Future research should focus on discovering early disease biomarkers, including surrogates for later cardiovascular disease, and evaluating biological agents as adjuncts to improve the rates of complete remission and subsequently influence the kidney outcome. The aim of this review article is to summarize the current kidney outcomes for this disease with a view to identifying key areas that may help to reduce the risk of long-term CKD.
No effect of gestational diabetes or pre-gestational obesity on 6-year offspring left ventricular function—RADIEL study follow-up
Authors: Litwin Linda , Sundholm Johnny K. M. , Rönö Kristiina , Koivusalo Saila B. , Eriksson Johan G. , Sarkola Taisto
Published: July 2020

Aims

We aimed to investigate associations between pre-pregnancy obesity, gestational diabetes (GDM), offspring body composition, and left ventricular diastolic and systolic function in early childhood.

Methods

This is an observational study, including 201 mother–child pairs originating from the Finnish Gestational Diabetes Prevention Study (RADIEL; 96 with GDM, 128 with pre-pregnancy obesity) with follow-up from gestation to 6-year postpartum. Follow-up included dyads anthropometrics, body composition, blood pressure, and child left ventricular function with comprehensive echocardiography (conventional and strain imaging).

Results

Offspring left ventricular diastolic and systolic function was not associated with gestational glucose concentrations, GDM, or pregravida obesity. Child body fat percentage correlated with maternal pre-pregnancy BMI in the setting of maternal obesity (r = 0.23, P = 0.009). After adjusting for child lean body mass, age, sex, systolic BP, resting HR, maternal lean body mass, pre-gestational BMI, and GDM status, child left atrial volume increased by 0.3 ml (95% CI 0.1, 0.5) for each 1% increase in child body fat percentage.

Conclusions

No evidence of foetal cardiac programming related to GDM or maternal pre-pregnancy obesity was observed in early childhood. Maternal pre-pregnancy obesity is associated with early weight gain. Child adiposity in early childhood is independently associated with increased left atrial volume, but its implications for long-term left ventricle diastolic function and cardiovascular health remain unknown.
A methodology for projecting sparse populations and its application to remote Indigenous communities
Authors: Dockery Alfred Michael , Harris Mark N. , Holyoak Nicholas , Singh Ranjodh B.
Published: July 2020

A new method is proposed for generating projections for sparse populations by locality, age cohort and gender. An adaptation of the cohort replacement method, the approach uses a Tobit model with varying censoring limits to model population changes by cohort. As an applied example, projections are generated for 2016 Indigenous populations in communities in regional and remote Australia, and then compared to actual 2016 Census population counts. We argue the approach has considerable potential, with the model performing well in out-of-sample projection while offering projections at a much finer-grained level of disaggregation than currently available to planners and policy-makers.
Common Fiscal Capacity Is Needed to Strengthen Risk Sharing
Authors: Díaz Antonia
Published: July 2020

This asymmetric effect of the shock on economic activities becomes an asymmetric impact on countries depending on their sectoral composition.
“How Do They Even Know They Love?” The Image of Polyamory in Polish Expert Discourse
Authors: Grunt-Mejer Katarzyna , Chańska Weronika
Published: July 2020

The article presents the results of a thematic analysis of statements about polyamory made in the media by Polish psychology and sexology experts. The analysis was conducted on the basis of 20 pieces of material released in the Polish national press, radio, and television between July 2012 and October 2018. The results show that most of the analyzed experts approach polyamory with suspicion. In most cases, the decision to be in a polyamorous relationship is assessed very negatively, and in the eyes of the therapists it is evidence of psychological defects in people who make such attempts or it is seen as a harbinger of unfavorable outcomes for the relationship. This negative psychological evaluation is often accompanied by a strong moral assessment and a clear willingness to discourage society from this relationship model. The results show that representatives of psychology and medical sciences in the Polish media support and legitimize the social and moral order that promotes mono-normativity. The true reasons for the aforementioned negative assessment are hidden behind a veil of scientific objectivity.
Cloud Computing Mobile Application for Remote Monitoring of Bell’s Palsy
Authors: Watts P , Breedon P , Nduka C , Neville C , Venables V , Clarke S
Published: July 2020

Mobile applications provide the healthcare industry with a means of connecting with patients in their own home utilizing their own personal mobile devices such as tablets and phones. This allows therapists to monitor the progress of people under their care from a remote location and all with the added benefit that patients are familiar with their own mobile devices; thereby reducing the time required to train patients with the new technology. There is also the added benefit to the health service that there is no additional cost required to purchase devices for use. The Facial Remote Activity Monitoring Eyewear (FRAME) mobile application and web service framework has been designed to work on the IOS and android platforms, the two most commonly used today. Results: The system utilizes secure cloud based data storage to collect, analyse and store data, this allows for near real time, secure access remotely by therapists to monitor their patients and intervene when required. The underlying framework has been designed to be secure, anonymous and flexible to ensure compliance with the data protection act and the latest General Data Protection Regulation (GDPR); this new standard came into effect in April 2018 and replaces the Data Protection Act in the UK and Europe.
Unsupervised representation learning with Minimax distance measures
Authors: Haghir Chehreghani Morteza
Published: July 2020

We investigate the use of Minimax distances to extract in a nonparametric way the features that capture the unknown underlying patterns and structures in the data. We develop a general-purpose and computationally efficient framework to employ Minimax distances with many machine learning methods that perform on numerical data. We study both computing the pairwise Minimax distances for all pairs of objects and as well as computing the Minimax distances of all the objects to/from a fixed (test) object. We first efficiently compute the pairwise Minimax distances between the objects, using the equivalence of Minimax distances over a graph and over a minimum spanning tree constructed on that. Then, we perform an embedding of the pairwise Minimax distances into a new vector space, such that their squared Euclidean distances in the new space equal to the pairwise Minimax distances in the original space. We also study the case of having multiple pairwise Minimax matrices, instead of a single one. Thereby, we propose an embedding via first summing up the centered matrices and then performing an eigenvalue decomposition to obtain the relevant features. In the following, we study computing Minimax distances from a fixed (test) object which can be used for instance inK-nearest neighbor search. Similar to the case of all-pair pairwise Minimax distances, we develop an efficient and general-purpose algorithm that is applicable with any arbitrary base distance measure. Moreover, we investigate in detail the edges selected by the Minimax distances and thereby explore the ability of Minimax distances in detecting outlier objects. Finally, for each setting, we perform several experiments to demonstrate the effectiveness of our framework.
Huge typical pulmonary carcinoid presented with gigantism syndrome
Authors: Beshay Morris , Gutierrez Federico , Windmöller Beatrice Ariane , Förster Christina , Mertzlufft Fritz
Published: July 2020

A 27-year-old male patient presented with cough and right-sided, light thoracic pain. His physical appearance showed typical features of gigantism. Subsequently, further diagnostic work-up showed elevated level of growth hormone and a huge tumor of the right lung, identifying a typical pulmonary carcinoid tumor (TPCT). Curative surgery was performed leading to normalization of the elevated growth hormone levels few days after surgery. Two- and five-year follow-up showed no signs of recurrence. Respected to tumor size, we determined the largest TPCT to be reported in medical literature history.
Interventions that Facilitate Shared Decision-Making in Cancers with Active Surveillance as Treatment Option: a Systematic Review of Literature
Authors: Collée G. E. , van der Wilk B. J. , van Lanschot J. J. B. , Busschbach J. J. , Timmermans L. , Lagarde S. M. , Kranenburg L. W.
Published: July 2020

Purpose of review

Medical decisions concerning active surveillance are complex, especially when evidence on superiority of one of the treatments is lacking. Decision aids have been developed to facilitate shared decision-making on whether to pursue an active surveillance strategy. However, it is unclear how these decision aids are designed and which outcomes are considered relevant. The purpose of this study is to systematically review all decision aids in the field of oncological active surveillance strategies and outcomes used by authors to assess their efficacy.

Recent findings

A search was performed in Embase, Medline, Web of Science, Cochrane, PsycINFO Ovid and Google Scholar until June 2019. Eligible studies concerned interventions aiming to facilitate shared decision-making for patients confronted with several treatment alternatives, with active surveillance being one of the treatment alternatives. Twenty-three eligible articles were included. Twenty-one articles included patients with prostate cancer, one with thyroid cancer and one with ovarian cancer. Interventions mostly consisted of an interactive web-based decision aid format. After categorization of outcomes, seven main groups were identified: knowledge, involvement in decision-making, decisional conflict, treatment preference, decision regret, anxiety and health-related outcomes.

Although active surveillance has been implemented for several malignancies, interventions that facilitate shared decision-making between active surveillance and other equally effective treatment alternatives are scarce. Future research should focus on developing interventions for malignancies like rectal cancer and oesophageal cancer as well. The efficacy of interventions is mostly assessed using short-term outcomes.
A community of advantage or mutual respect?
Authors: Hargreaves Heap Shaun P.
Published: July 2020

This paper reviews the points of continuity and change between Sugden’s new book and his classic from the 1980s, The Political Economy of Welfare, Rights and Cooperation. It argues that while his new responses to the ‘nudging’ revolution and rising inequality have sharpened his argument for, respectively, the economist as ‘contractarian’ adviser to citizenry model and his defence of the market as an institution of mutual benefit, the introduction of Adam Smith’s concept of ‘mutual sympathy’ is double-edged. It fills a psychological gap in Hume that is important for ‘contractarian’ proposals to citizenry, but it also suggests we might plausibly be interested in something more than mutual benefit when deciding what rules to be regulated by.
Detection of breast cancer precursor lesions by autofluorescence ductoscopy
Authors: Waaijer Laurien , Filipe Mando D. , Simons Janine , van der Pol Carmen C. , de Boorder Tjeerd , van Diest Paul J. , Witkamp Arjen Joost
Published: July 2020

Purpose

Autofluorescence is an image enhancement technique used for the detection of cancer precursor lesions in pulmonary and gastrointestinal endoscopy. This study evaluated the feasibility of addition of autofluorescence to ductoscopy for the detection of intraductal breast cancer precursor lesions.

Methods

An autofluorescence imaging system, producing real-time computed images combining fluorescence intensities, was coupled to a conventional white light ductoscopy system. Prior to surgery, ductoscopy with white light and autofluorescence was evaluated under general anaesthesia in women scheduled for therapeutic or prophylactic mastectomy. Endoscopic findings in both modes were compared, marked and correlated with histology of the surgical specimen.

Results

Four breast cancer patients and five high-risk women, with a median age of 47 years (range 23–62) were included. In autofluorescence mode, two intraductal lesions were seen in two breast cancer patients, which had an increase in the red-to-green fluorescence intensity compared with the surrounding tissue. One lesion had initially been missed by white light ductoscopy but was clearly visible in subsequent autofluorescence mode. One endoscopic finding was classified as suspicious by white light, but was negative in autofluorescence mode and showed normal histology.

Conclusions

This study demonstrates for the first time the in vivo feasibility of autofluorescence ductoscopy to detect pathologically confirmed breast cancer precursor lesions in both breast cancer patients and high-risk women that were occult under white light.
Extracting Maritime Traffic Networks from AIS Data Using Evolutionary Algorithm
Authors: Filipiak Dominik , Węcel Krzysztof , Stróżyna Milena , Michalak Michał , Abramowicz Witold
Published: July 2020

The presented method reconstructs a network (a graph) from AIS data, which reflects vessel traffic and can be used for route planning. The approach consists of three main steps: maneuvering points detection, waypoints discovery, and edge construction. The maneuvering points detection uses the CUSUM method and reduces the amount of data for further processing. The genetic algorithm with spatial partitioning is used for waypoints discovery. Finally, edges connecting these waypoints form the final maritime traffic network. The approach aims at advancing the practice of maritime voyage planning, which is typically done manually by a ship’s navigation officer. The authors demonstrate the results of the implementation using Apache Spark, a popular distributed and parallel computing framework. The method is evaluated by comparing the results with an on-line voyage planning application. The evaluation shows that the approach has the capacity to generate a graph which resembles the real-world maritime traffic network.
Late Quaternary sedimentation dynamics in the Beenchime-Salaatinsky Crater, Northern Yakutia
Authors: Schwamborn Georg , Manthey Christoph , Diekmann Bernhard , Raschke Ulli , Zhuravlev Anatoly , Prokopiev Andrei V. , Schirrmeister Lutz
Published: July 2020

The Beenchime-Salaatinsky Crater (BSC) is located west of the Olenyok River in Northern Yakutia, ~ 260 km south-west of Tiksi and the Lena Delta. The age and origin (volcanic versus meteoritic) of this crater is poorly understood. The key scientific interest in re-visiting the BSC is the reappraisal of the Quaternary sedimentation dynamics for a better understanding of the sediment history and thickness in the basin. This aides for an assessment, if the site is prospective for a deeper drilling of a Quaternary (or Cenozoic) sediment archive. Soil pits and auger cores from slopes and lowland terrain in the basin were sampled and studied to infer sediment ages and transport dynamics. This also included a thermokarst lake placed in the centre of the basin. Studied properties include grain-size distribution, organic carbon and nitrogen contents (TOC and TN), heavy mineral compositions, δ13C of organic carbon, 14C ages from sediment, δ18O and δD from ground ice and waters, and lake bathymetry from GPR profiling, in addition. We conclude that the crater floor in the BSC is underlain by fluvial/alluvial sediments from the MIS 3 period. Thermokarst lake formation took place during the Holocene Thermal Maximum between 7600 and 6100 cal yr BP. The lake has been shrinking hereafter. Fluvial/alluvial sedimentation along the drainage pattern was active again between 5700 to 1500 cal yr BP, and it was flanked by the accumulation of peaty and organic-rich sediments and the formation of ice-wedge polygons.
Customized Frozen Embryo Transfer after Identification of the Receptivity Window with a Transcriptomic Approach Improves the Implantation and Live Birth Rates in Patients with Repeated Implantation Failure
Authors: Haouzi Delphine , Entezami Frida , Torre Antoine , Innocenti Charlène , Antoine Yannick , Mauries Charlotte , Vincens Claire , Bringer-Deutsch Sophie , Gala Anna , Ferrieres-HOA Alice , Ohl Jeanine , Gonzalez Marti Beatriz , Brouillet Sophie , Hamamah Samir
Published: July 2020

The aim of this prospective study was to evaluate outcome benefits expected in repeated implantation failure (RIF) patients (n = 217) after customized embryo transfer based upon identification of the receptivity window by transcriptomic approach using the Win-Test. In this test, the expression of 11 endometrial genes known to be predictive of endometrial receptivity is assessed by RT-PCR in biopsies collected during the implantation window (6–9 days after the spontaneous luteinizing hormone surge during natural cycles, 5–9 days after progesterone administration during hormone replacement therapy cycles). Then, patients underwent either customized embryo transfer (cET, n = 157 patients) according to the Win-Test results or embryo transfer according to the classical procedure (control group, n = 60). Pregnancy and live birth rates were compared in the two groups. The Win-Test showed that in 78.5% of women, the receptivity window lasted less than 48 h, although it could be shorter (< 24 h, 9.5%) or longer (> 48 h, 12%). This highlighted that only in 20% of patients with RIF the endometrium would have been receptive if the classical embryo transfer protocol was followed. In the other 80% of patients, the receptivity window was delayed by 1–3 days relative to the classical timing. This suggests that implantation failure could be linked to inadequate timing of embryo transfer. In agreement, both implantation (22.7% vs. 7.2%) and live birth rates per patient (31.8% vs. 8.3%) were significantly higher in the cET group than in the control group. cET on the basis of the Win-Test results could be proposed to improve pregnancy and live birth rates.

ClinicalTrials.gov ID: NCT04192396; December 5, 2019, retrospectively registered.
Experimental evidence, scaling and public policy: a perspective from developing countries
Authors: MANI ANANDI
Published: July 2020

I highlight two important factors particular to less-developed countries that can bias evidence generation and contribute to the ‘voltage drop’ in programme benefits, moving from field research experiments to policy implementation at scale. The first is the non-linear increase in information processing and coordination costs associated with upscaling in less-developed countries, given limited state capacity and rigid organizational hierarchies. The second is political bias in the choice of programmes considered for rigorous evaluation itself, resulting in distorted evidence and policy choice. These two factors raise considerations that complement the economics-based approach outlined by Al-Ubaydli et al. in the quest for more rigorous, evidence-based policy.
Enhancing the Robustness of Causal Claims Based on Case Study Research on Conflict Zones: Observations from Fieldwork in Donbas
Authors: Wolff Stefan
Published: July 2020

Focusing on process tracing and using the example of fieldwork in Donbas, I develop an argument on what theoretically grounded and empirically detailed methodological solutions can be considered to mitigate the challenges of research on conflict zones and assure the robustness of any causal claims made. I first outline my assumptions about process tracing as the central case study method and its application to research on conflict zones, and then discuss in more detail data requirements, data collection, and data analysis. Using two examples of case studies on the war in and over Donbas, I illustrate how three standards of best-practice in process tracing—the need for a theory-guided inquiry, the necessity to enhance causal inference by paying attention to (and ruling out) rival explanations, and the importance of transparency in the design and execution of research—can be applied in the challenging circumstances of fieldwork-based case studies of conflict zones. I conclude by suggesting that as a minimum threshold for reliance upon causal inferences, these three standards also should align with a standard of evidence that requires both the theoretical and empirical plausibility of any conclusions drawn.
ON GILP’S GROUP-THEORETIC APPROACH TO FALCONER’S DISTANCE PROBLEM
Authors: YU HAN
Published: July 2020

In this paper, we follow and extend a group-theoretic method introduced by Greenleaf–Iosevich–Liu–Palsson (GILP) to study finite points configurations spanned by Borel sets in
$\mathbb{R}^n,n\geq 2,n\in\mathbb{N}.$
We remove a technical continuity condition in a GILP’s theorem in [Revista Mat. Iberoamer31 (2015), 799–810]. This allows us to extend the Wolff–Erdogan dimension bound for distance sets to finite points configurations with k points for
$k\in\{2,\dots,n+1\}$
forming a
$(k-1)$
-simplex.
Effect of fermentation time and acid casein concentration as nitrogen source on microbial rennet production
Authors: Fileto-Pérez Héctor A. , Montoya-Ayón Luis G. , Soto-García Esther , Páez-Lerma Jesús B. , Soto-Cruz Nicolás O. , García-Caballero Blanca E. , Rutiaga-Quiñones José G.
Published: July 2020

We evaluated the effects of fermentation time and acid casein content on the microbial rennet obtained by solid-state fermentation using wheat bran as the carbon source. The experiments used two fermentation times (72 and 96 h), while acid casein content was 1.5, 2.0, 2.5, and 3.0 g. Rennet strength from eight enzymatic extracts was measured using pasteurized whole milk. Rennet strength of samples from 72 h of fermentation showed an increase when acid casein content increased. The rennet strength increased at 96 h of fermentation with increasing amount of casein (up to 2.5 g), and then decreased with the largest addition (3.0 g) of casein. Coagulation time for the sample with highest rennet strength was 420 s.
The challenge of performing mastoidectomy using the operating microscope with coronavirus disease 2019 personal protective equipment (PPE)
Authors: Clamp P J , Broomfield S J
Published: July 2020

Objective

Mastoidectomy is considered an aerosol-generating procedure. This study examined the effect of wearing personal protective equipment on the view achieved using the operating microscope.

Methods

ENT surgeons assessed the area of a calibrated target visible through an operating microscope whilst wearing a range of personal protective equipment, with prescription glasses when required. The distance between the surgeon's eye and the microscope was measured in each personal protective equipment condition.

Results

Eleven surgeons participated. The distance from the eye to the microscope inversely correlated with the diameter and area visible (p < 0.001). The median area visible while wearing the filtering facepiece code 3 mask and full-face visor was 4 per cent (range, 4–16 per cent).

Conclusion

The full-face visor is incompatible with the operating microscope. Solutions offering adequate eye protection for aerosol-generating procedures that require the microscope, including mastoidectomy, are urgently needed. Low-profile safety goggles should have a working distance of less than 20 mm and be compatible with prescription lenses.
‘Solemn and just demands’: Seeking apologies in the international arena
Authors: Adams Tracy , Kampf Zohar
Published: July 2020

Demands for apology are a prominent rhetorical means for pointing out transgressions in contemporary world politics. They transform ‘seen but unnoticed’ conduct into ‘seen and noticed’ transgression and attach a price tag to the restoration of damaged relations. Nevertheless, compared to the widely discussed practice of apologising, demands for apologies have received scant scholarly attention. In this article we adopt an actor-oriented perspective in order to situate the speech act of demanding an apology within the delicate management of interstate relations. In-depth content analysis of 57 cases of demands made by various state actors in a variety of diplomatic contexts between 1999 and 2019 let us delineate the discursive construction of transgressions, the normative scripts that inform acts of demands, the types of sought-after remedies, and their discursive consequences. We conclude by discussing the normative diplomatic scripts that guide demands for apology and how these speech acts reconfigure power relations in international politics.
TrimethylamineN-oxide: heart of the microbiota–CVD nexus?
Authors: Naghipour Saba , Cox Amanda J. , Peart Jason N. , Du Toit Eugene F. , Headrick John P.
Published: July 2020

We critically review potential involvement of trimethylamineN-oxide (TMAO) as a link between diet, the gut microbiota and CVD. Generated primarily from dietary choline and carnitine by gut bacteria and hepatic flavin-containing mono-oxygenase (FMO) activity, TMAO could promote cardiometabolic disease when chronically elevated. However, control of circulating TMAO is poorly understood, and diet, age, body mass, sex hormones, renal clearance, FMO3 expression and genetic background may explain as little as 25 % of TMAO variance. The basis of elevations with obesity, diabetes, atherosclerosis or CHD is similarly ill-defined, although gut microbiota profiles/remodelling appear critical. Elevated TMAO could promote CVD via inflammation, oxidative stress, scavenger receptor up-regulation, reverse cholesterol transport (RCT) inhibition, and cardiovascular dysfunction. However, concentrations influencing inflammation, scavenger receptors and RCT (≥100 µm) are only achieved in advanced heart failure or chronic kidney disease (CKD), and greatly exceed pathogenicity of <1–5 µmlevels implied in some TMAO–CVD associations. There is also evidence that CVD risk is insensitive to TMAO variance beyond these levels in omnivores and vegetarians, and that major TMAO sources are cardioprotective. Assessing available evidence suggests that modest elevations in TMAO (≤10 µm) are a non-pathogenic consequence of diverse risk factors (ageing, obesity, dyslipidaemia, insulin resistance/diabetes, renal dysfunction), indirectly reflecting CVD risk without participating mechanistically. Nonetheless, TMAO may surpass a pathogenic threshold as a consequence of CVD/CKD, secondarily promoting disease progression. TMAO might thus reflect early CVD risk while providing a prognostic biomarker or secondary target in established disease, although mechanistic contributions to CVD await confirmation.
Assessment of trans-fatty acid content in a sample of foods from the Slovenian food supply using a sales-weighting approach
Authors: Kušar Anita , Hribar Maša , Lavriša Živa , Zupanič Nina , Pivk Kupirovič Urška , Hristov Hristo , Abramovič Helena , Vidrih Rajko , Zlatić Emil , Kokalj Doris , Piskernik Saša , Mencin Marjeta , Peče Petra , Blaznik Urška , Žmitek Katja , Pravst Igor
Published: July 2020

Objective:

Consumption of trans-fatty acids (TFA) is a well-established risk factor for CVD morbidity and mortality. Our objective was to investigate TFA levels in Slovenian food supply.

Design:

Cross-sectional study.

Setting:

Selected foods (n 282) were purchased in Slovenia (2016), and the TFA content was determined. The sample included pre-packed foods with/without declared partially hydrogenated vegetable oils (PHO), as well as non-pre-packed foods. A sales-weighting approach was used to ponder different market shares of the products.

Results:

While the majority of the investigated samples had low levels of TFA, up to 6·8 g of TFA per 100 g of food was observed in certain foods. Within pre-packed foods (n 207), the highest proportion of samples with high TFA levels was found among cookies with labelled PHO: 69 % (n 18) would exceed European Union regulatory TFA limit (2 g industrial TFA per 100 g of fats), which will be implemented in April 2021. Among the investigated non-pre-packed foods (n 75), only croissants contained notable TFA levels (mean 0·90 (sd 0·97); maximum 3·3 g/100 g), with about half of the samples exceeding 2 g TFA per 100 g of fats.

Conclusions:

In 2016, some foods in Slovenian food supply still contained notable amounts of TFA. Foods with listed PHO as an ingredient were usually higher in TFA as compared with foods not labelled to contain PHO. Biscuits were identified as the most concerning category of pre-packed foods, while croissants contained highest levels of TFA within non-pre-packed foods.
Lord, Peasant … and Tractor? Agricultural Mechanization, Moore’s Thesis, and the Emergence of Democracy
Authors: Samuels David J. , Thomson Henry
Published: July 2020

Conventional wisdom holds that landed elites oppose democratization. Whether they fear rising wages, labor mobility or land redistribution, landowners have historically repressed agricultural workers and sustained autocracy. What might change landowning elites’ preferences for dictatorship and reduce their opposition to democracy? Change requires reducing landowners’ need to maintain political control over labor. This transition occurs when mechanization reduces the demand for agricultural workers, eliminating the need for labor-repressive policies. We explain how the adoption of labor-saving technology in agriculture alters landowners’ political preferences for different regimes, so that the more mechanized the agricultural sector, the more likely is democracy to emerge and survive. Our theoretical argument offers a parsimonious revision to Moore’s thesis that applies to the global transformation of agriculture since hisSocial Originsfirst appeared, and results from our cross-national statistical analyses strongly suggest that a positive relationship between agricultural mechanization and democracy does in fact exist.
Developing communities: the Ford Foundation and the global urban crisis, 1958–66
Authors: Collings-Wells Sam
Published: July 2020

Between 1958 and 1966 the Ford Foundation embarked on a series of pilot projects of ‘urban community development’ in India and the United States. This article will highlight how both of these programmes emerged in response to what Ford officials understood to be a global urban crisis, caused by the migration of ‘backward’ rural populations into the cities. Rather than modernizing under the pressure of urban living, these newcomers appeared to be pooling into pockets of underdevelopment – ‘ghettos’ in the United States and ‘slums’ in India. Ford sought to tackle the problem by encouraging the participation of these marginalized communities in the process of urban renewal, a strategy intended to engineer the psychological modernization of their residents. In practice, however, Ford struggled to control the channels into which these mobilizations flowed, with poor urban residents utilizing the projects to push for radical changes concerning housing, policing, and tenant–landlord relations.
The Gendered Debate: Do Men and Women Communicate Differently in the House of Commons?
Authors: Hargrave Lotte , Langengen Tone
Published: July 2020

It has long been claimed in the gender and politics literature that male and female legislators have different communication styles. The evidence for this claim has come mostly from interviews with legislators as the key informants on gendered differences. We contribute to this literature in two ways: First, we empirically examine speeches by Members of Parliament to establish whether gendered differences are observable in parliamentary debates. Second, we advance existing measurement approaches by testing for multiple dimensions of communication style, providing a more systematic approach to studying gendered speech behavior. Communication style is examined through a content analysis of almost 200 speeches in three parliamentary sessions of the British House of Commons. We find compelling evidence for differences in communication style: women evidence arguments with personal experience, discuss policies in a concrete way, and are less adversarial than men. Our findings have important implications for how political communication styles might improve public engagement with politicians, offer a different focus to the discussion, and improve democratic legitimacy.
A Feminist Call to Be Radical: Linking Women's Health and Planetary Health
Authors: Tanyag Maria
Published: July 2020

iwishi couldw riteth epoemi

wantor eadina timeo fcrisis

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ineed towriteth epoemi

wantor eadina timeo fcrisis

{repeat}

thisi snotth epoemi

needtow riteina timeo fcrisis

{repeat}

thisi sjustat est ofawri terina

timeo fcrisis

{repeat}

—Teresia Teaiwa (2013)

Reflecting on the two previous conversations in Politics & Gender (2015 and 2017) regarding the diverging paths in global political economy and security studies that feminist international relations (IR) scholars have taken, I am reminded of Teresia Teaiwa's poetry, which for me speaks about how crisis gives birth to the radical starting points of our feminist inquiries. We are all undoubtedly on the cusp of ever-intensifying forms of insecurities, and peoples who have least contributed to their creation and hastening are bearing the worst impacts. It is projected that by 2100, the compounded threats that humanity will face as a result of climate change will be in multitudes across five main human systems: health, water, food, economy, infrastructure, and security (Cramer et al. 2018; Mora et al. 2018, 106). The complex consequences of climate change demand an approach that encompasses the interaction effects of different risks and hazards. However, across natural and social sciences so far, the norm has been to focus on specific aspects of human life and to examine hazards–including conflict and violence—in isolation from one another. We then run the risk of misleading ourselves with partial, if not incorrect, assessments of the global processes surrounding climate change. In particular, we are yet to understand the multiscalar dynamics of environmental degradation and extreme weather as they are entangled with other crises such as armed conflicts, health pandemics, economic recessions, and resurgences of authoritarian leadership. Whether feminist or not, we simply cannot afford to think in “camps” instead of “bridges” given the nature of the multiple crises we as humanity are facing. As Anna M. Aganthangelou (2017, 741) points out, “[g]lobal politics are never just ‘economic’ or ‘security’ issues,” so the kind of assumptions we hold and how these inform the questions we raise need to “attend to the highest stake of politics: existence.”
Positive effect of curcumin on experimental peridontitis via suppression of IL-1-beta and IL-6 expression level
Authors: Yetkin Ay Zuhal , Bakır Burcu , Bozkurt Şerife Buket , Kayis Seyit Ali , Hakki Sema Sezgin
Published: July 2020

Abstract. This study examined the effect of curcumin on T-helper (Th17) and T-regulatory (Treg) cells regarding the mRNA of cytokines/mediators in the gingiva. Thirty-five male albino Wistar rats were divided into four groups: Group 1: periodontitis (n = 9); Group 2: periodontitis with curcumin treatment (n = 8); Group 3: periodontally healthy with curcumin treatment (n = 10); and Group 4: periodontally healthy (n = 8). Curcumin was administered via oral gavage (30 mg/kg/day) for a total of 15 days. The gingival tissues were investigated regarding mRNA expressions of Th17/Treg cytokines with qRT-PCR. The distributional properties of the data were evaluated using the Anderson-Darling normality test. Kruskal-Wallis and Mann-Whitney U tests were employed for multiple group comparisons. Partial least squares regression discriminant analysis (PLS-DA) was used to evaluate the degree of contribution of each mRNA to the separation of treatment groups. When the periodontitis groups were compared, curcumin treatment resulted in lower IL-1β (Group 2 median: 0.002, Group 1 median: 0.12) and IL-6 (Group 2 median: 0.031, Group 1 median: 0.078) and higher IL-17 (Group 2 median: 1.07, Group 1 median: 0.583) relative mRNA expression in Group 2 than in Group 1 (p < 0.001). Group 3 also had higher IL-10 relative expression (median: 0.067) than Groups 1 and 4 (median: 0.028, 0.007, respectively. p < 0.001). These results indicate that curcumin might be a promising agent for the prevention and/or treatment of periodontal diseases due to its decreasing effect on IL-1β and IL-6 mRNA expression.
Tracking Seasonal and Interannual Variability in Photosynthetic Downregulation in Response to Water Stress at a Temperate Deciduous Forest
Authors: He Liyin , Wood Jeffrey D. , Sun Ying , Magney Troy , Dutta Debsunder , Köhler Philipp , Zhang Yongguang , Yin Yi , Frankenberg Christian
Published: July 2020

The understanding and modeling of photosynthetic dynamics affected by climate variability can be highly uncertain. In this paper, we examined a well‐characterized eddy covariance site in a drought‐prone temperate deciduous broadleaf forest combining tower measurements and satellite observations. We find that an increase in spring temperature usually leads to enhanced spring gross primary production (GPP), but a GPP reduction in late growing season due to water limitation. We evaluated how well a coupled fluorescence‐photosynthesis model (SCOPE) and satellite data sets track the interannual and seasonal variations of tower GPP from 2007 to 2016. In SCOPE, a simple stress factor scaling of Vcmax as a linear function of observed predawn leaf water potential (ψpd) shows a good agreement between modeled and measured interannual variations in both GPP and solar‐induced chlorophyll fluorescence (SIF) from the Global Ozone Monitoring Experiment‐2 (GOME‐2). The modeled and satellite‐observed changes in SIFyield are ~30% smaller than corresponding changes in light use efficiency (LUE) under severe stress, for which a common linear SIF to GPP scaling would underestimate the stress reduction in GPP. Overall, GOME‐2 SIF tracks interannual tower GPP variations better than satellite vegetations indices (VIs) representing canopy “greenness.” However, it is still challenging to attribute observed SIF variations unequivocally to greenness or physiological changes due to large GOME‐2 footprint. Higher‐resolution SIF data sets (e.g., TROPOMI) already show the potential to well capture the downregulation of late‐season GPP and could pave the way to better disentangle canopy structural and physiological changes in the future.