bluuebunny/crossref_metadata_2025 huggingface dataset:
A biointegration of microand nanocrystalline hydroxyapatite: problems and perspectives
Authors: Pankratov A. S , Fadeeva IS. S , Minaychev V. V , Kirsanova P. O , Senotov A. S , Yurasova Yu. B , Akatov V. S
Published: December 2018

Сalcium phosphate materials have been applied in clinical medicine since 1920. Among calcium phosphate materials, hydroxyapatite (HAp) is traditionally of the greatest interest, because HAp is the main inorganic component of bone tissues. However, synthetic HAр ceramics subjected to high-temperature processing, as it turned out, have a rather limited use as an osteoplastic material. Since 1990, due to advances in chemical technology, new materials of pasty nanocrystalline HAр have been developed, which are promising for the directed influence on the process of bone tissue regeneration. This review briefly summarizes the experimental and clinical data related to the application of micro- and nano-sized hydroxyapatite, and evaluated the potential of pasty nanocrystalline HAp as a material for guided bone regeneration.
The key stages of iPSCs differentiation into neuronal and glial cells
Authors: Salikhova D. I , Fedyunina IA. , Bukharova T. B , Goldshtein D. V , Kiselev S. L
Published: December 2018

Brain's neurodegenerative diseases are one of the most actual problems of neurology and neurobiology. The lack of the modern methods of treating this diseases stimulates to develop new effective approaches based on neuronal and glial cells, which requires studying the signaling mechanisms of neural differentiation. This review considers the key mechanisms and substances involved in the formation of the neuroepithelium in vivo, as well as for obtaining the neural stem cells from iPSCs and its further differentiation in various types of neuronal and glial cells in vitro.
The change in the quantity of macrophages and their stabilin-1 + M2 subpopulation in the myocardium in patients during early postinfarction period
Authors: Rebenkova M. S , Gombozhapova A. E , Rogovskaya Y. V , Ryabov VV. V , Churina EG. G , Kzhyshkowska J. G
Published: December 2018

Investigation of the role of macrophages and their functional plasticity in reparative process accompanying myocardial infarction (MI) and postinfarction cardiac remodeling is the relevant issue of current medical science. The purpose of the study: to investigate CD68+ and stabilin-1 +-macrophage infiltration and its dynamics in patients with MI in comparison with intact myocardium. The study included patients with fatal MI type 1 (n=41). All patients were divided into 4 groups depending on the onset of death (group 1, n=13, patients who died during the first 24 hours of MI; group 2, n=11, patients who died within 24-72 hours of MI; group 3, n=9, patients who died on days 4-10; and group 4, n=8, patients who died 11-28 days after MI). The control group included patients (n=9) who died due to fatal trauma and who did not suffer from cardiovascular pathology. For evaluation of functional immunopheno-type of macrophages we used immunohistochemistry. We counted cells expressing on their surface a common macrophages marker - CD68 and specific marker of regulatory M2 macrophages that demonstrates an anti-inflammatory activity - stabilin-1 in the infarct area, peri-infarct area, and non-infarct area. In comparison with the intact myocardium (control group) the number of CD68+-macrophages in the infarct area, periinfarct area, and non-infarct area increased from the first day of disease and peaked on day 4-10. The quantity of stabilin-1 + macrophages in all zones investigated during the acute phase of MI was lower than in the intact myocardium and increased on day 4-10 in the infarct area. Furthermore, in the non-infarct zone the quantity of stabilin-1 +-macrophages was lower than its quantity in the control group both during the acute phase and the regenerative phase of MI. The data obtained indicate the participation of stabilin-1 + macrophages in process of postinfarction myocardial healing and the development of the inflammatory immune response in the myocardium during the acute phase of MI and its maintaining at late stages of the disease.
A study of physical and biological properties of 3D matrices made from polytrimethylene carbonate and its copolymers
Authors: Chernonosova V. S , Gostev AA. , Kharkova M. V , Pokushalov EA. , Karpenko AA. A , Karaskov A. M , Laktionov P. P
Published: December 2018

The development of new materials for using in different parts of medicine (for replacement of affected vessels, cartilage, connective, glandular tissue) has recently become widespread, due to the high rate of occurrence of these pathologies and the need for surgical treatment of these pathologies. One of the promising approaches is the production of tissue engineered matrices from various polymers and their mixtures by the electrospinning. Block polymers (for example, trimethylene carbonate) are of particular interest for fabrication of tissue engineered devices due to the ability to customize the polymer stability by using different sets of blocks. 3D matrices were prepared from solutions of polytrimethylene carbonate (PTMC) and its copolymers with polycaprolactone and lactic acid in various solvents (dichloromethane with dimethylformamide, pure dichloromethane or hexafluoroisopropanol) by electrospinning. Scaffolds were prepared from mixtures of polymers with gelatin. The structure of the matrices was characterized by the scanning electron microscopy method. Hydrophilicity and mechanical strength of the matrices were investigated. The ability of primary human umbilical vein endothelial cells (HUVEC) to attach and proliferate on the surfaces of different matrices was studied. The tensile strength of the matrices, produced from dichloromethane solutions was not more than 0.22 MPa, and the strength of the scaffolds produced from hexafluoroisopropanol solutions reached 4.3 MPa. HUVEC successfully attached to the matrices, but proliferation rate was slow. During storage the matrices produced from the PTMC and its copolymers had a tendency to absorb water vapor, and exhibited shrinkage, fusion of the fibers and strength loss. 3D matrices produced from PTMC cannot be recommended for the manufacture of implantable devices but can tentatively serve as biodegradable scaffolds in tissue engineering without constant hydrodynamic loading, such as areas of connective or glandular tissue.
Clinical and pathological features DNMT3A, FLT3, KIT, NPM1, NRAS, TP53 and wT1 genes mutations detection in acute myeloid leukemia patients aged 15-45 years old
Authors: Vinogradov A. V , Rezaykin A. V , Sazonov S. V , Sergeev A. G
Published: December 2018

The frequency of acute myeloid leukemia (AML) increases with age, respectively, the range of identified gene mutations and the pathways involved carcinogenesis can vary and affect the prognosis of treatment. The aim of the study was to estimate the frequency of mutations in DNMT3A, FLT3, KIT, NPM1, NRAS, TP53 and WT1 genes in acute myeloid leukemia (AML) patients (pts) aged 15-45 years old using direct automatic sequencing technique. Bone marrow and peripheral blood samples obtained from 36 AML pts aged 15 to 45. Distribution of the pts according to FAB-classification was as follows: AML M0 - 2, M1 - 1, M2 - 15, М3 - 2, M4 - 11, M4eo - 2, M5 - 2, blastic plasmacytoid dendritic cell neoplasm-1. Detection of mutations in ASXL1, DNMT3A, FLT3, KIT, NPM1, NRAS, TP53 and WT1 genes performed by automatic direct sequencing technique. The average frequency of functionally significant mutations in all investigated genes among the treated AML pts was 41,7 % (n=15), including 6 cases (40,0 %) with unfavorable cytogenetics, 6 cases (54,5 %) with normal karyotype, 3 cases (37,5 %) with favorable cytogenetics. These data correspond to the average frequency of point mutation in AML with normal and abnormal karyotype. Average frequency of mutations in FLT3 gene exons 12-15 and 19-21 - 21,9 %, NRAS gene exons 1-4 - 13,0 %, WT1 gene exons 6-9 - 11,1%, NPM1 gene exons 9-12 was 10,7 %, KIT gene exons 7-12 and 16-19 - 10,0 %, DNMT3A exons 18-26 - 7,1 %, TP53 gene exons 4-11 - 0,0 %. Multiple point mutations in investigated genes detected in 13.9 % AML specimens (usually KIT gene non-synonymous substitution c. 1621 А>С). Cryptic gene mutations detection using direct sequencing technique allowed to clarify the prognostic stratification of AML from groups of favorable and intermediate prognosis in 36,8 % (n=7). Thus, using of cytogenetic and additional molecular genetic research, a favorable prognosis of overall survival was established in 6 cases (16,7 %), intermediate - in 10 cases (27,8 %), adverse - in 18 cases (50,0 %), and unspecified - in 2 (5,6 %).
A combination of small molecular inhibitors YAC increases expression levels of DMRT1 in the culture of sertoli cells from the transitional zone of mouse testis
Authors: Kulibin A. Yu , Malolina EA. A
Published: December 2018

There is a cell population capable of active proliferation in culture in the compartment of adult mouse testis consisting of transitional zone of seminiferous tubules and rete testis. These cells were termed Sertoli cells of the transitional zone because they express many specific Sertoli cell genes in culture. A feature of these cells is a low level of Dmrt1 expression, a transcription factor important for Sertoli cell differentiation and male sex determination. In the current research, the culture conditions have been optimized to increase Dmrt1 expression in Sertoli cells of the transitional zone and then functional properties of these cells have been tested. It was shown that a combination of small molecular inhibitors YAC (Y-27632, A-83-01 and CHIR99021) substantially increases the number of Sertoli cells of the transitional zone expressing Dmrt1. It was demonstrated that Sertoli cells of the transitional zone maintained in medium with YAC remain the high level of Dmrt1 expression even after their transfer to 3D culture where they form seminiferous tubule-like structures with neonatal testicular cells. According to immunofluorescence and real-time PCR data Sertoli cells treated with YAC supported germ cell differentiation to the zygotene stage of meiotic prophase I in 3D culture. These results suggest that Sertoli cells of the transitional zone maintained in medium with YAC closely resemble Sertoli cells from seminiferous tubules and can function as Sertoli cells in 3D culture.
Angiogenic properties of myocardial c-kit+ cells
Authors: Dergilev K. V , Tsokolaeva Z. I , Beloglazova I. B , Ratner E. I , Molokotina Yu. D , Parfenova E. V
Published: December 2018

Now, great interest is connected with application of the cells received directly from a myocardium as the tool for stimulation of angiogenesis and reparative processes in heart. The aim of the present research is studying of angiogenic properties in vitro and in vivo of c-kit+-cells, obtained from hearts of small rodents. The work was performed on male C57BL/6 mice and male Wistar rats. The study used methods of cytofluorimetry, immuno-fluorescent staining, models of myocardial infarction and subcutaneous angiogenesis in Matrigel™. It was shown, that after acute myocardial infarction c-kit+ cells activated, part of which entered into endothelial differentiation and integrated into de novo formed vessels. C-kit+-expressed the markers of vascular progenitor cells, exhibited endothelial-like behavior in vitro, and after subcutaneous transplantation increased vascularization of Matrigel™. This is achieved both due to the paracrine effects, which stimulate the growth of the recipient's mouse vessels into the Matrigel implant, and partially due to the differentiation of the transplanted cells into the vascular endothelium cells, which was confirmed by vital dye staining. Thus, c-kit+-cells derived from the myocardium can be considered as a promising type of resident cells exhibiting the properties of progenitor cells of the heart vessels for developing approaches to stimulate vascularization of the ischemic myocardium.
Analysis of in vitro cytotoxicity of human NK cell line co-expressing a PSMA-specific CAR and an antitumor agent lactaptin
Authors: Belovezhets T. N , Matvienko DA. , Volkova O. Y , Koval OA. A , Tkachenko A. V , Kuligina E. V , Taranin A. V , Richter VA.
Published: December 2018

Development of efficient antitumor modalities remains a priority of modern translation medicine. Adoptive transfer of autologous T cells expressing chimeric antigen receptors (CARs) specific for tumor-associated surface targets of B cells has demonstrated encouraging results in recent clinical trials. It is tempting therefore to adapt this approach to solid cancers and move it to universal/allogeneic formats. For this reason, it appears very attractive to use human NK cell lines as CAR carriers. Using lentiviral delivery, human NK cell line YT was modified to express a PSMA-specific CAR and to produce an anticancer peptide lactaptin. "Armored” CAR-YT-Lact cell line obtained shows cytotoxicity against PSMA-positive prostate adenocarcinoma cells. Accordingly, YT-Lact cells display a moderate and non-specific activity against PSMA-negative target cells, which may translate into a tighter control of tumor cell escape via antigen loss.
Opportunities of using gene therapy in patient with non-reconstructable critical limb ischemia in proximal reocclusion
Authors: Chervyakov Yu. V , Ha H. N
Published: December 2018

The aim of the study: to evaluate the effect of complex treatment on "no-option” patients with aortoiliac reocclusion using a plasmid-based with VEGF165 gene therapy in the 3-year follow-up study. Material and methods. In total, 3 patients with Leriche's syndrome in stage III, IV of chronic lower limb ischemia (according to the classification of Fontaine-Pokrovsky) were treated and observed in the 3-year follow-up study. All patients were men, the average age was 58 years. All patients underwent surgical reconstruction of the aortoiliac segment. In the period from 1 to 3 years after the initial intervention, there was a reocclusion of the aortoiliac segment. Based on the results of angiography, these patients were classified as non-reconstructable due to total occlusion of lower extremity arteries. All patients received standard conservative treatment in combination with gene therapy. Endpoints of the study: the survival rate, the limb salvage rate. Results: During 3-year follow-up two patients are alive, one dead due to unrelated with Leriche's syndrome reasons, the limb salvage rate was 100 %.
FITNESS AND PATHOGENICITY OF OUTBREAK CAUSING Salmonella UPON SHORT-TERM EXPOSURE TO GROUNDWATER WITH RESIDUAL ANTIBIOTICS
Authors: HAZNEDAROĞLU Berat Zeki
Published: December 2018

The changes in survival and
pathogenicity of three Salmonella
enterica subsp. enterica
serotypes upon short term exposure to groundwater with residual antibiotics
have been studied in relationship to overall microbial fitness. A wild type
flagellated Salmonella enterica ser.
Typhimurium outbreak strain, a mutant Salmonella
enterica ser. Typhimurium strain, and a wild type avian disease-causing Salmonella enterica ser. Pullorum strain
were exposed to a range of ionic strength (3-30 mM) groundwater with residual
antibiotics for 6-24 hours. Exposed organisms’ pathogenicity was tested in
vitro exposure to a human epithelial cell line (HEp2). Resistance profiles
against 10 common antibiotics were also tested and compared to unexposed
controls. Results show minor antibiotic resistance changes for S. enterica ser. Typhimurium strains in
response to some antibiotic classes mediated with active efflux pumps. This
trend was not observed for S. enterica ser.
Pullorum, suggesting that resistance found in groundwater exposed organisms
might be strain-dependent. In vitro epithelial cell invasion assays showed
bacterial invasion of HEp2 cells initially decreases with time and increases
after 24 hours. It is concluded that S.
enterica serotypes reaching groundwater environments in the presence of
residual antibiotics may exhibit increased levels of pathogenicity,
strain-dependent resistance to antibiotics, and sustained levels of viability.
Tadris al Ta’biir al Syafahii bi al Thoriqoh al Ittishooliyah li Thulaab Qism Ta’lim al Lughoh al ‘Arabiyyah bi Jaami’ati Muhammadiyah Tangerang
Authors: Rohman Faedur
Published: December 2018

مستخلص البحث:ينطلق هذا البحث من مشكلة التي يواجهها طلاب قسم تعليم اللغة العربية بجامعة محمدية تانجرانج، حيث صعوبتهم على ممارسة التعبير الشفهي. ويهدف هذا البحث لكشفها، ولوصف الخطة الاجرائية عما يتعلق بتدريس التعبير الشفهي بالطريقة الاتصالية وأثرها في ترقية كفاءة التعبير الشفهي لطلاب قسم تعليم اللغة العربية في جامعة محمدية تانجرانج. هذا البحث بحث نوعي، ويُخْتَصّ هذا البحث في دراسة حالة لأنها يُقَصّده الباحث لمعرفة المشكلة التي يواجهها الطلاب في التعبير الشفهي ومراحل تدريسه بالطريقة الاتصالية التي تجري في الفصل وأثرها شاملا وعامقا. وتشير نتيجة هذا البحث: الأول، أن المشكلة التي يواجهها الطلاب في تدريس التعبير الشفهي هي: أ). قلة التدريبات اللغوية الشفوهية، ب). قلة حفظ المفردات الموضوعية، ج). قلة التواصل بين الطلاب باللغة العربية، د). قلة اهتمام بالمواد المدروس، هـ) أن التعبير الشفهي الذي يمارسه الطلاب غير منتَظِم. الثاني، أن تدريس التعبير الشفهي بالطريقة الاتصالية على ثلاث مراحل إجرائية، وهي الخطة، والتنفيذ، والتقويم. والثالث، إن استخدام الطريقة الاتصالية فعال في ترقية كفاءة التعبير الشفهي.الكلمات المفتاحية: تدريس، التعبير الشفهي، الطريقة الإتصالية AbstrackThis research departs from the problems faced by the students of the Arabic Language Education Department of Muhammadiyah University in Tangerang in the ta'bir syafahi (verbal expression) practice. The purpose of this study was to reveal the problems faced by students in teaching ta'bir syafahi and also the procedures for using communicative methods in teaching ta'bir syafahi and their effectiveness in improving ta'bir syafahi competencies in Arabic Language Education students at Muhammadiyah University in Tangerang. This study uses a qualitative approach; and including the type of case study because researchers want to know deeply and comprehensively about the problem ta'bir syafahi experienced by students, the stages of teaching, and the impact of the application of communicative methods in ta'bir syafahi learning. The results of this study indicate that: First, the problems faced by students of the University of Muhammadiyah Tangerang in teaching ta'bir syafahi include: a). lack of oral language training, b). treasury of thematic mufradat is still minimal, c). the intensity of Arabic communication is still lacking, d). lack of attention to the material being taught, e). less systematic in conveying ideas. Second, the procedure for applying communicative methods in ta'bir syafahi includes three things, namely: a). Planning, b). Implementation, c). Evaluation. Third, the use of communicative methods is effective in improving the competency of ta'bir syafahi.Keywords: Communicative Method, Teaching, Ta'bir Syafahi
“Um bando chamado desejo”: imagens de corpos, gêneros e sexualidades por professores/as de ciências em formação
Authors: Gurgel Evanilson , Maknamara Marlécio
Published: December 2018

Com vínculo nas pesquisas (auto)biográficas em perspectiva pós-crítica, tomam-se como material empírico narrativas (auto)biográficas de docentes de ciências em formação inicial. O objetivo é visibilizar imagens de corpos, gêneros e sexualidades presentes em suas histórias de vida. Para analisar os ditos desses/as professores/as, investigamos suas falas no intuito de procurar vestígios, traços e marcas de como os elementos da “trinca” corpos, gêneros e sexualidades podem emergir em suas narrativas. Os resultados são organizados em três tópicos: desterritorializar, despalavrear e cinematografar, em torno dos quais são problematizadas as imagens de corpos, gêneros e sexualidades. Apenas uma das professoras em formação conseguiu, com base em suas imagens de corpos, gêneros e sexualidades, inferir que são elementos conectáveis às suas futuras práticas de ensino.
Leitura de imagens como possibilidade de aproximação entre arte e ciência
Authors: Silva Josie , Neves Marcos
Published: December 2018

Todas as áreas utilizam e criam imagens, mas nem sempre possuem um referencial teórico, questão com a qual a arte pode contribuir. Considerando que arte e ciência são faces do conhecimento, é apresentada uma proposta de leitura de imagem interdisciplinar que possa ser aplicada em diferentes áreas. O referencial teórico baseia-se em abordagens epistemológicas de Umberto Eco, Paul Valèry e Edgar Morin, e em teóricos da leitura de imagem, como Lucia Santaella, Erwin Panofsky e Horst Bredekamp. A partir dessas contribuições, é elaborada uma leitura de imagem com quatro passos: análise da forma, análise do conteúdo, análise das relações que envolvem a imagem (autor versus contexto versus leitor) e análise interpretativa do leitor.
FORGOTTEN PAGES OF HISTORY: A. P. BYSTROV (1899–1959)
Authors: Beresneva O. N. , Parastaeva M. M.
Published: December 2018

The article is devoted to the outstanding scientist anatomist, paleontologist, doctor of biological sciences, lieutenant-colonel of medical service A. P. Bystrov (1899–1959), who lived only 60 years. Twenty-five years he was connected with the military department, two years worked inMoscowin the Paleontological Institute, the last 13 years of his life he taught at the geological faculty ofLeningradstate university.
EXPERIENCE WITH THE USE OF PIOGLITAZONE FOR THE PREVENTION AND TREATMENT OF EXPERIMENTAL URATE NEPHROLITHIASIS
Authors: Perfiliev V. Y. , Zverev Y. F. , Zharikov A. Y. , Lukiyanenko D. Y. , Lysenko I. V. , Atabaeva O. S.
Published: December 2018

THE AIM. To assess the effectiveness of selective agonist of PPAR gamma receptors (Peroxisome Proliferator-Activated Receptor) pioglitazone, as a drug of prevention and treatment of experimental urate nephropathy. MATERIAL AND METHODS. The study was conducted on 37 male rats Wistar stock. For the formation of urate nephropathy in rats inhibited uricase by co-administration of uric acid and oxonium. For the prevention and treatment of experimental pathology animals received pioglitazone. On day 21 using biochemical and morphological techniques were evaluated received changes. RESULTS. In the experimental condition were observed significant decrease of urate stones in kidneys, significant decrease of uric acid in blood plasma and urine of rats, increase of the urine pH, increase of glomerular filtration rate and inhibition processes of free radical oxidation in the blood of animals. CONCLUSION. Long-term use of pioglitazone in the preventive and therapeutic modes, significantly improves the experimental urate nephrolithiasis.
ELECTROLYTES CONCENTRATION REFERENCE LIMITS IN AMNIOTIC FLUID OF RABBITS ON 27-28 DAY OF GESTATION
Authors: Suzopov E. V. , Lytar I. A. , Popovtceva A. V. , Korenovskii Y. V.
Published: December 2018

THE AIM: to determine reference limits of volume, osmolality and concentration of Na+, K+, Cl−, non-organic phosphate (Pi ), and Ca2+ in amniotic fluid (AF) of rabbits on 27-28 day of gestation. MATERIALS AND METHODS: during research on first-pregnant rabbits (n=6), received 37 samples of AF, determined fetal mass, fetal part of placenta mass, volume, osmolality and concentration of Na+, K+, Cl−, Pi , and Ca2+. RESULTS: obtained reference limits of volume (0,09–1,63 ml), osmolality (210,0–267,0, mOsmol/kg), concentration of ions Na+ (110,0–146,0 mmol/l), K+ (6,0–12,4 mmol/l), Cl– (87,0–117,0 mmol/l), Ca2+ (1,88– 2,89 mmol/l) and Pi (0,56–1,57 mmol/l) in AF. Reverse correlation of AF volume with fetus mass (r = -0,525, p < 0,001) and positive correlation between fetus mass and AF osmolality (r = 0,375, p = 0,022) were determined. Concentrations of Na+, K+, Cl− are correlated with placenta mass (r = 0,368, p = 0,025; r = 0,353, p = 0,032; r = 0,381, p = 0,020, respectively). AF osmolality correlated with concentrations of Na+ (r = 0,514, p < 0,001) and Cl(r = 0,510, p < 0,001). CONCLUSION: results could be used for developing animal models of medicamental influence on AF volume, osmolality and ion composition on late gestation.
EFFECT OF THERMAL ISCHEMIA-REPERFUSION ON EXPRESSION OF APOPTOSIS-REGULATING GENES IN THE RENAL TISSUE OF PATIENTS WITH RENAL CELL CARCINOMA
Authors: Kutilin D. S. , Dimitriadi S. N. , Vodolazhsky D. I. , Frantsiyants E. M. , Kit O. I.
Published: December 2018

Improved knowledge of molecular mechanisms of the damaging effect of thermal ischemia and reperfusion to renal tissue of patients with renal cancer has significant prospects for new therapeutic approaches aimed at enhancing quality of care. THE AIM: to study changes in the expression of apoptosis-regulating genes MDM 2, BAX, CASP7, CASP3, CASP8, CASP9, BCL2, CASP8 / FADD, p53, APAF1, AIFM1, ICAD and XIAP in renal tissue of patients with renal cell carcinoma subjected to the action of ischemia and reperfusion. PATIENTS AND METHODS. We used for the study tissue biopsies of 12 patients with histologically confirmed diagnosis of renal cancer. Needle biopsy was performed before stop the blood supply, for 10 minutes of ischemia and 20 minutes after reperfusion in the kidney. The relative expression of genetic loci was determined by real-time PCR. RESULTS. It was found: 1) absence from the 10th minute of ischemia significant differences transcriptome profile of the majority of investigated genes from similar parameters prior to ischemia, with the exception of reducing expression of genes CASP7 and ICAD; 2) a significant increase in expression of pro-apoptotic genes (BAX, CASP3/7, APAF1 and p53), and anti-apoptotic genes (XIAP, MDM2 and BCL2) 20 minutes after reperfusion of the kidney tissue; 3) a changes in the balance of expression of pairs of proand anti-apoptotic genes p53 / MDM2 and Bax / BCL2 in the 10th minute of ischemia and 20 minutes after reperfusion. CONCLUSION. These data characterize transcriptomic state of renal tissue in the early period after ischemia and restore the blood flow in it as the initiation point shift the balance of proand anti-apoptotic genes.
RENAL FUNCTION IN ADOLESCENTS WITH OBESITY
Authors: Petrosyan E. K. , Kostereva E. A. , Novikov S. Y. , Moreno I. G. , Shumilov P. V.
Published: December 2018

THE AIM.Determining the effect of obesity on renal function in children.PATIENTS AND METHODS.The study included 35 adolescents (30 boys and 5 girls, mean age 14.6±2.2 years) with overweight and differing degrees of obesity. In addition to clinical examination determined the presence and severity of risk factors for kidney disease in obesity, especially insulin resistance, lipid metabolism with the definition of atherogenic index (AI). To assess kidney function determined microalbuminuria (MAU) and glomerular filtration rate.RESULTS. Renal function in adolescents with obesity which manifests with increasing the excretion of albumin and decreasing the glomerular filtration rate (GFR) caused by lipid metabolism disorders: increase of lowdensity lipoprotein (LDL) level and decrease of high-density lipoprotein (HDL) level, which reflected on the atherogenic atherogenic index. The correlation between the level of MAU and GFR and atherogenic index (r= 0,42;p<0,05; r = -0,37;p<0.05) was shown, whereas between blood pressure and MAU, as well as between the degree of IR and impaired renal function in adolescents with obesity was absent. We have not found a relationship between blood pressure and MAU, as well as between the degree of IR and renal disorder in adolescents with obesity. Severity of IR depends on the level of HDL (r= -0,52; p<0,05). Disorder of BP biorhythm as insufficient diastolic night fall significantly affected on the renal function in the form of MAU (r = -0,37; p <0,05). It was found that the degree of overweight is not in direct correlation with the degree of lipid metabolism disorder (r = 0,2; p> 0,05).CONCLUSION. In adolescents with overweight and obesity renal function is inversely proportional correlated with severity of lipid metabolism disorder, intensity of which is not dependent on the degree of overweight.
Psychosocial factors in assessment of prognosis and prevention of ischemic heart disease associated with arterial hypertension and diabetes mellitus of type 2
Authors: Garganeeva N. P.
Published: December 2018

Correlation between the cardiovascular risk factors in predicting of the course of ischemic heart disease (IHD) associated with arterial hypertension (AH) and diabetes mellitus type 2 was studied in 85 patients admitted to the Borderline Condition Department for neurotic and affective disorders for development of a complex program of secondary prevention and rehabilitation. Logistical regression method was used for assessment of significance of the psychological factors and of other RF.
Practical effect of introduction of colorimetric and immuno chemical techniques at the establishment of presence of sperm on material evidences
Authors: Sidorov V. L. , Yagmurov O. D.
Published: December 2018

The authors analyze the experience of both domestic and of foreign authors in application of the methods for detection of rough and demonstrative presence of the sperm in the stains on the material evidences. Colorimetric method for definition of the acid phosphotase presence and the ELISA technique for definition of PSA are compared with other modern techniques applied in Russia. Sensitivity, objectivity, actuality, economyand other potentialities and advantages of both methods are more pronounced in forensic medicine practice.
Epileptic syndrome in the clinical picture of the diseaseand the level of antibodies to GluR1 subunit of AMPA glutamate receptors in the patients with gliomas in the cerebral hemispheres of a brain
Authors: Ochkolyas V. N. , Gurchin A. F. , Skoromets A. A. , Kostyukevich A. V.
Published: December 2018

The authors examined 92 patients with gliomas in the cerebral hemispheres. The immunoenzyme method was used for semiquantitative assay of the level of autoantibodies to GluR1 subunit of AMPA receptors of glutamate. Frequency and clinical features of symptomatic epilepsy, the reaction of AMPA receptors of glutamate depending on localization and degree of malignance and features of clinical course of the disease wereinvestigated as well. Marked increase of the level of autoantibodies to GluR1 subunit of AMPA receptors of glutamate was noticed in the patients with gliomas associated with epileptic syndrome. Maximal level of autoantibodies to GluR1 subunit of AMPA receptors of glutamate seen under the effect of the tumor on the frontal and temporal lobels.
Transmissible spongy encephalopathy (with a case report)
Authors: Shuleshova N. V. , Lovitskiy S. V. , Platonova I. S. , Dvorakovskaya I. V. , Baykov V. V.
Published: December 2018

The article presents the description of a case of spongy encephalopathy diagnosed morphologically in a 54 year old female. The disease lasted for 1-2 years, and had a lethal issue. The patient had undergone both out-patient and in-patient treatment in 4 city hospitals. The final diagnosis was maid after autopsy only. Difficulties of clinical diagnosis of Kreitsfeld Jacob disease which is one of the forms of transmissible spongy encephalopathy are discussed.
EEG indices in patients with high risk of ischemic stroke as predictors of initial disturbed cerebral circulation
Authors: Isaeva N. A. , Torubarov Ph. S. , Zvereva Z. Ph.
Published: December 2018

Abnormal changes were detected in EEG in patients with high risk of ischemic stroke (higher level than in the population). These changes show the disturbances in forming mechanisms of functional condition of cerebrum during the calm wakeful period. Changes were represented by: the registration of EEG IV- type (the E.A. Zhirmunsky type) which was characterized by disorganization of alpha activity and of slow waves; the instability of pattern during the record of background activity; the paroxysmal activity in form of flashes of the bilateral synchronized waves; the strengthening of low-frequency and high-amplitude β-activity. Revealed changes in EEG show the presence of initial disturbed cerebral circulation and can be recommended as predictors of these disturbances.
Time perspective of the convicts of acquisitive crime in the initial period of serving the sentence
Authors: Martynova A. A.
Published: December 2018

There were no statistically significant differences in the initial period of serving the sentence by all parameters of time perspective regardless of gender and the number of the previous records of acquisitive crime. A phenomenon of «perceptual distortion of course of life in the time continuum» was revealed. The degree of its manifestation affects the success of adaptation in the initial period of serving the sentence.
Features of prosthetic of lower edentulous jaw with a complex clinical picture
Authors: Parshin Yu. .
Published: December 2018

The greatest difficulties arise in the treatment of patients with complete loss of teeth on the lower jaw. One of the rational methods of prosthetics of the lower edentulous jaw in patients is the use of implants to support a removable denture. However, using even a small number (2 - 4) of the implants, as recommended by many clinicians, is negatively perceived by patients of elderly and senile age, because of the invasiveness and cost, which leads to a failure of implantation and use of traditional methods of prosthetics. Therefore, reducing the invasiveness of the intervention on the lower edentulous jaw and the use of a single implant is relevant in a complex clinical picture in this category of patients.
Non-thermal effects of mobile phone radiation on brain
Authors: Babalyan A. V. , Karelin A. O.
Published: December 2018

This article gives a review of major experimental studies devoted to the effect of mobile phone electromagnetic emission on brain. The most relevant and fundamental studies were reviewed. Both positive and negative results were analyzed to give a straight answer, if mobile phone emission effects brain electrophysiology, cognitive function, subjective symptoms and blood-brain barrier permeability.
Protein markers of mitochondria formation and alteration in patients with impaired blood circulation
Authors: Alekseevskaya E S. , Zhloba A. A. , Subbotina T. F. , Gaurilyuk N. D. , Druzhkova T. A. , Zhiduleva E. V. , Irtyuga O. B. , Moiseeva O. M.
Published: December 2018

Patients with abnormal left ventricular outflow tract had middle lactic acidemia with detected cytochrome C release into the bloodstream and liberation of protein PGC1a (peroxisome proliferator-activated receptor gamma coactivator-1alpha) with elevation its blood concentration reflecting mitochondrial biogenesis in tissues.
Nghiên cứu đánh giá hiện trạng sử dụng và chất lượng nước cấp sinh hoạt huyện Trảng Bàng, tỉnh Tây Ninh
Authors: Nguyễn Minh Kỳ
Published: December 2018

Bài báo trình bày kết quả nghiên cứu đánh giá hiện trạng sử dụng và chất lượng nước cấp sinh hoạt huyện Trảng Bàng, tỉnh Tây Ninh. Liên quan đến tình hình sử dụng nước sạch của người dân huyện Trảng Bàng có tỉ lệ người dân sử dụng nước hợp vệ sinh khá thấp. Đề tài tiến hành lấy mẫu, đánh giá chất lượng nước cấp đồng loạt tại các trạm cấp nước sạch nông thôn trên địa bàn các xã Phước Chỉ, Bình Thạnh và Phước Lưu. Kết quả phân tích các chỉ tiêu hóa lý chất lượng nước quan trọng của các trạm cấp nước sạch nông thôn huyện Trảng Bàng cho thấy, các thông số nằm trong giới hạn cho phép của quy chuẩn nước sử dụng cho sinh hoạt QCVN02:2009/BYT và nước cấp sử dụng cho ăn uống QCVN01:2009/BYT. Tuy nhiên, một số mẫu với chỉ số E.coli không đáp ứng điều kiện cấp nước cho sinh hoạt và ăn uống. Số liệu đánh giá tương quan giữa các thông số chất lượng nước nhìn chung có mối liên hệ chặt chẽ có ý nghĩa thống kê (p<0,05). Kết quả PCA trích xuất ba nhóm nhân tố chính (PCs) với chỉ số Eigenvalues bằng 1,287 tổng phương sai tích lũy tương ứng giải thích 86,426 % tập dữ liệu. Qua đó có thể sử dụng nhằm đánh giá và diễn giải tình trạng chất lượng nước cấp sinh hoạt trên địa bàn huyện Trảng Bàng, tỉnh Tây Ninh.
THỬ NGHIỆM ĐÁNH GIÁ KHẢ NĂNG HẤP PHỤ XỬ LÝ PHENOL TRONG NƯỚC CỦA VẬT LIỆU COPOLYME (P.DVINYLBENZEN-STYREN)
Authors: Thu Bui
Published: December 2018

Vật liệu Copoly (P.divinylbenzen-styren) xốp được tổng hợp bằng phương pháp đồng trùng hợp gốc tự do trong dung dịch huyền phù. Tính chất đặc trưng của vật liệu được xác định bằng các kỹ thuật đo phổ hồng ngoại IR, kính hiển vi điện tử quét (SEM), phân tích nhiệt DSC-TGA. Diện tích bề mặt riêng và tính chất xốp của vật liệu được đánh giá thông qua phương pháp BET, dung lượng hấp phụ cực đại và các yếu tố ảnh hưởng tới quá trình hấp phụ xử lý phenol trong nước của vật liệu copolyme xốp đã được khảo sát. Vật liệu copolyme có cấu trúc mạng lưới xốp, diện tích bề mặt riêng xác định theo BET là 589,45m2/g, theo phương trình Langmuir là 866,14 m2/g, kích thước lỗ xốp trung bình 3,5-20 nm. Ảnh hưởng thời gian, pH, nồng độ dung dịch đầu tới quá trình hấp phụ xử lý phenol của vật liệu đã được khảo sát. Vật liệu cho lượng hấp phụ cực đại đối với phenol trong nước đạt 75,2 (mg/g).
Authors: Anh Le Hoang
Published: December 2018

Coal, wood, agricultural waste, and liquid petroleum gas (LPG) are among the major fuel materials used for cookstove in Vietnam. However, the use of these energy sources is controversial since they are also the sources of hiden indoor air pollution which could adversely impact human health. In current study, particulate matter concentrations (PM10, PM2.5, PM1) are monitored by GRIMM 107-G (Grimm Technologies, Inc., Douglasville, GA, USA) throughout cooking time using different fuels such as coal, wood, and LPG. The results show that the indoor concentrations of particulate matters tend to be higher than those of ambient air. Among the distinguished fuels, wood produces the highest PM10, PM2.5, PM1 concentrations, up to 305.7 ± 105.3 µg/m3; 158.3 ± 35.4 µg/m3; 135.9 ± 31,0 µg/m3 respectively. The PM10 indoor and outdoor ratios during cooking time using different fuels such as coal, wood, and LPGare 2.67; 1.18; 0.92 respectively. These high concentration of particulate matters in the kitchen is harmful for people, especially the wives in the household who have longer exposure time to those pollutants.
Authors: Nguyễn Tài Tuệ , Dũng Lưu Việt , Nhuận Mai Trọng
Published: December 2018

The objective of the present research aims to identify the distribution and sources of organic carbon in surface sediments of mangrove forests from Mui Ca Mau National Park using stable isotope analysis. Results showed that water content, LOI, TN, TOC and C/N ratios in surface sediments of the fringe mangrove forest were lower than those in surface sediments of the interior forest. In contrast, the bulk sediment density, δ13C and δ15N in surface sediments of the fringe mangrove forests were higher than those in sediments of the interior mangrove forest. The non-linear relationship between δ13C and C/N ratios indicated that sources of organic carbon in surface sediments of the fringe mangrove forest were mainly from tidal particulate organic matter and phytoplankton, the sedimentary organic carbon in the interior mangrove forests mainly originated from mangrove litters. The present study demonstrated that the distribution and sources of organic carbon in surface sediments of mangrove forests from Mui Ca Mau National Park are changed following the succession of mangrove forests and the distance from the river bank towards the interior mangrove forests. Results from present study will contribute the scientific fundamental for implementing the studies that aim to examine the ecological functions of mangrove forests in maintaining biodiversity of aquatic animals and to reconstruct the paleoenvironment in the mangrove intertidal zone using stable isotopes.
KẾT HỢP ẢNH VỆ TINH LANDSAT 8 VÀ SENTINEL 2 TRONG NÂNG CAO ĐỘ PHÂN GIẢI NHIỆT ĐỘ BỀ MẶT
Authors: Trinh Le Hung
Published: December 2018

Nhiệt độ bề mặt là một trong những yếu tố quan trọng nhất trong nghiên cứu hiện tượng đảo nhiệt đô thị, giám sát cháy rừng, cháy mỏ than cũng như là thông số đầu vào cho các mô hình khí hậu. Các quan trắc mặt đất chỉ phản ánh điều kiện nhiệt của khu vực cục bộ xung quanh trạm đo và trên thực tế cũng không thể thiết lập nhiều trạm quan trắc với mật độ dày do chí phí cao. Công nghệ viễn thám với những ưu điểm vượt trội như diện tích vùng phủ của một ảnh rộng, chu kỳ cập nhật ngắn đã được ứng dụng hiệu quả trong nghiên cứu sự phân bố nhiệt độ bề mặt. Mặc dù vậy, do độ phân giải không gian ở các kênh hồng ngoại nhiệt thấp, nhiệt độ bề mặt xác định từ các ảnh vệ tinh như Landsat, Aster thường khó áp dụng hiệu quả cho các nghiên cứu ở quy mô nhỏ. Bài báo này trình bày kết quả kết hợp ảnh vệ tinh Landsat 8 và Sentinel 2 trong nâng cao độ phân giải nhiệt độ bề mặt. Kết quả nhận được cho thấy, trong trường hợp kết hợp sử dụng ảnh vệ tinh Sentinel 2 và Landsat 8, độ phân giải nhiệt độ bề mặt được nâng cao lên 10 m so với 30 m khi chỉ sử dụng ảnh Landsat 8. Đối với 2 khu vực thử nghiệm, so sánh giá trị nhiệt độ thấp nhất và cao nhất cũng như tại 10 điểm kiểm tra ngẫu nhiên cho thấy, độ chênh lệch nhiệt độ bề mặt khi kết hợp ảnh Landsat 8 và Sentinel 2 so với phương pháp truyền thống chỉ sử dụng ảnh Landsat 8 là không đáng kể.
Technically, the selection of Simulated annealing parameters, for instance, initial temperature, temperature decreasing function, function to generate new points only impact how the shape of the plot and how fast this model converge. From several trials,
Authors: Bùi Quang Thành
Published: December 2018

Adaptive Neuro-Inference system (Anfis) has been widely used in recent studies aiming at generating probabilities of unseen data in binary classification application. It is normally used in combination with optimization algorithms for tuning its parameters to generate optimal objective values. This study proposed a novel method using Simulated Annealing to improve Anfis performance. Malaria occurrences and spatial variation of environmental, socio-economic factors in Daknong province, Vietnam were selected for case study. For accuracy assessment, Receiver Operating Characteristic curve, Cost curve were used and the predicted map was compared to several benchmark classifiers. The results showed that the S-Anfis (AUC = 0.912, RMSE =0.335) outperformed Support Vector Machine (AUC = 0.902, RMSE =0.364), Multiple LayerPerceptron (AUC = 0.868, RMSE =0.430). Although, the performance of S-Anfis depended on proper selection of input factors and geographic variations of those, we concluded that this method could be an alternative in mapping susceptibility of malaria.
The geochemical characteristics of seawater and surface sediment of 60-100m depth in Quang Binh sea area
Authors: Hoang Van Hiep , Nguyen Nguyen Dinh
Published: December 2018

The geochemical characteristics of seawater and surface sediment represent the stability of seawater quality. There is a lack of information on geochemical characteristics of elements in seawater well as sediment in the sea area of Quang Binh province. The objective of this paper is to study and determine the characteristics of the marine environment through elemental geochemistry in seawater and surface sediments of Quang Binh area to assess the stability and quality of seawater in this area. The results show that seawater environment is characterized by a shallow sea with rare effect on continental water. The difference in salinity values, Eh, pH,...at different depth is indistinguishable. The sedimentary environment is weak alkaline, the environment from decontamination to strong oxidation. Cu and As elements distributed in sediments are mostly concentrated in the center of the study area.
A Nghiên cứu xử lý axit styphnic trong nước bằng hệ UV-H2O2/TiO2
Authors: Khải Nguyễn Mạnh
Published: December 2018

Nghiên cứu này tập trung vào việc khảo sát khả năng ứng dụng chất xúc tác quang TiO2 vào quá trình oxy hóa nâng cao UV-H2O2 để phân hủy axit Styphnic (TNR) trong nước thải của các cơ sở sản xuất thuốc phóng, thuốc nổ quốc phòng. Nghiên cứu được tiến hành trên cơ sở xác định sự suy giảm nồng độ của TNR trong nước với sự có mặt của nano TiO2, tác nhân oxy hóa H2O2 sau một khoảng thời gian (0-90 phút) chiếu tia UV. Các yếu tố như pH, bước sóng, tỉ lệ mol H2O2/TiO2, nhiệt độ, nồng độ chất ban đầu đều có ảnh hưởng rõ rệt đến hiệu suất phân hủy TNR trong nước. Kết quả nghiên cứu cho thấy tại điều kiện C0TNR = 154,40 mg/L, tỉ lệ mol H2O2/TiO2=15, pH = 3, λ= 313nm, 100% TNR bị phân hủy trong 90 phút. Ngoài ra, nhiệt độ không làm ảnh hưởng nhiều đến vận tốc và hiệu suất phân hủy TNR.
Đánh giá sự tích lũy và rủi ro sinh thái một số kim loại nặng trong trầm tích mặt khu vực hạ lưu sông Đáy
Authors: Tham Trinh Thi
Published: December 2018

Theo số liệu thống kê của các cơ quan quản lý, hệ thống lưu vực sông Nhuệ - Đáy đang chịu sự gia tăng về số lượng và lưu lượng nguồn thải nước thải từ các hoạt động sản xuất, sinh hoạt. Các nguồn thải mang theo các chất hữu cơ, kim loại nặng, vi sinh vật,… tích lũy trong trầm tích và hệ sinh thái dưới nước gây ảnh hưởng đến môi trường nước và hệ sinh thái. Trong nghiên cứu này, sự tích lũy kim loại nặng trong trầm tích tại khu vực hạ lưu sông Đáy được đánh giá thông qua chỉ số rủi ro sinh thái  tiềm năng của một số kim loại trong trầm tích. Kết quả nghiên cứu, trong 22 mẫu trầm tích tại khu vực hạ lưu sông Đáy đều phát hiện sự có mặt của các kim loại Cu, Pb, Cd, Cr với hàm lượng dao động trong khoảng tương ứng là 15,8 ÷ 82,6; 13,1÷ 72,1; 0,189 ÷ 2,43; 16,1 ÷ 97,3 mg/kg trọng lượng khô. Chỉ số rủi ro sinh thái tiềm năng của các kim loại nằm trong khoảng từ 11,4 đến 78,7 nên khu vực nghiên cứu có mức độ rủi ro kim loại thấp. Số liệu này có thể làm rõ mức độ rủi ro tiềm năng của khu vực và là cơ sở khoa học của các biện pháp kiểm soát và giảm thiểu các nguồn gây ô nhiễm môi trường từ các hoạt động kinh tế xã hội của lưu vực sông Nhuệ - Đáy.
The use of financial policy in adjusting the mobilization of high-quality science and technology human resources in the context of international integration (Case study of the Vietnam Academy of Science and Technology)
Authors: Dao Thanh Truong , Chu Hoài Thu
Published: December 2018

Di động xã hội của nhân lực khoa học và công nghệ (KH&CN) là một hiện tượng tự nhiên, là nhu cầu của cá nhân nhà khoa học. Trong bối cảnh hội nhập kinh tế quốc tế, đặc biệt là hội nhập về khoa học và công nghệ, cùng với sự phát triển của công nghệ thông tin, các luồng di động xã hội của nhân lực KH&CN đặc biệt là nguồn nhân lực trình độ cao đang diễn ra rất sôi động, đa dạng và phức tạp. Trên cơ sở khảo sát thực trạng của các luồng di động tại Viện cũng như các nỗ lực của Viện trong việc đề ra các chính sách nhằm đảm bảo công tác quản lý nhân lực KH&CN phát triển đội ngũ cán bộ cả về chất và về lượng, điều chỉnh các xu hướng biến động về dòng chảy “chất xám”, khai thác hiệu quả nguồn chất xám hiện có. Bản chất quản lý nhân lực trong điều kiện kinh tế thị trường là định hướng di động xã hội. Để định hướng di động xã hội của nhân lực KH&CN có nhiều biện pháp nhưng luận văn tập trung vào sử dụng chính sách tài chính để điều chỉnh di động xã hội, đặc biệt di động xã hội của nguồn nhân lực trình độ cao theo những hướng nhất định như di động từ nghiên cứu cơ bản sang nghiên cứu ứng dụng; sử dụng đa dạng hóa hoạt động để khai thác tối đa năng lực của nhân lực khoa học và công nghệ.
INCLUSIVE LEARNING ENVIRONMENT FOR STUDENTS WITH DISABILITIES IN VIETNAM’S HIGHER EDUCATION – AN ANALYSIS OF THE EXISTING POLICIES AND LEGAL FRAMEWORK
Authors: Nguyen Thuy Anh
Published: December 2018

Vietnam is one of the countries that have the highest numbers of persons with disabilities (PWDs). According to the 2009 Census there are approximately 6.1 million PWDs accounting for 7.8% of Vietnamese population. Research has shown that the number of PWDs who attend higher education in Vietnam is extremely low and only 0.1% of PWDs has completed a bachelor program at higher education level. The purpose of this paper is to provide an overview of the status of PWDs in Vietnam as well as analyse the country’s legal framework and policies governing PWDs. To this end, the paper firstly presents facts and figures regarding PWDs in Vietnam. Secondly, the paper reviews Vietnam’s commitments to international policies and standards, and the legal framework and policies towards PWDs in general and students with disabilities (SWDs) in particular at the national level. Finally, it points out some issues and challenges for Vietnam in creating a more inclusive learning environment for PWDs and SWDs at higher education