bluuebunny/crossref_metadata_2025 huggingface dataset:
The VarA-CsrA regulatory pathway influences cell shape in Vibrio cholerae
Authors: Lemos Rocha Leonardo F. , Peters Katharina , Biboy Jacob , Depelteau Jamie S. , Briegel Ariane , Vollmer Waldemar , Blokesch Melanie
Published: March 2022

Despite extensive studies on the curve-shaped bacterium Vibrio cholerae, the causative agent of the diarrheal disease cholera, its virulence-associated regulatory two-component signal transduction system VarS/VarA is not well understood. This pathway, which mainly signals through the downstream protein CsrA, is highly conserved among gamma-proteobacteria, indicating there is likely a broader function of this system beyond virulence regulation. In this study, we investigated the VarA-CsrA signaling pathway and discovered a previously unrecognized link to the shape of the bacterium. We observed that varA-deficient V. cholerae cells showed an abnormal spherical morphology during late-stage growth. Through peptidoglycan (PG) composition analyses, we discovered that these mutant bacteria contained an increased content of disaccharide dipeptides and reduced peptide crosslinks, consistent with the atypical cellular shape. The spherical shape correlated with the CsrA-dependent overproduction of aspartate ammonia lyase (AspA) in varA mutant cells, which likely depleted the cellular aspartate pool; therefore, the synthesis of the PG precursor amino acid meso-diaminopimelic acid was impaired. Importantly, this phenotype, and the overall cell rounding, could be prevented by means of cell wall recycling. Collectively, our data provide new insights into how V. cholerae use the VarA-CsrA signaling system to adjust its morphology upon unidentified external cues in its environment.
Concordance of ompA types in children re-infected with ocular Chlamydia trachomatis following mass azithromycin treatment for trachoma
Authors: Mosenia Arman , Chin Stephanie A. , Alemayehu Wondu , Melese Muluken , Lakew Takele , Zhou Zhaoxia , Doan Thuy , Cevallos Vicky , Lietman Thomas M. , Keenan Jeremy D.
Published: March 2022

Background

The chlamydial major outer membrane protein, encoded by the ompA gene, is a primary target for chlamydial vaccine research. However, human studies of ompA-specific immunity are limited, and prior studies have been limited in differentiating re-infection from persistent infection. The purpose of this study was to assess whether children living in trachoma-endemic communities with re-infections of ocular chlamydia were more likely to be infected with a different or similar genovar.

Methodology and findings

The study included 21 communities from a trachoma-hyperendemic area of Ethiopia that had been treated with a mass azithromycin distribution for trachoma. Conjunctival swabbing was offered to all children younger than 5 years of age at baseline (i.e., pre-treatment), and then at follow-up visits 2 and 6 months later. Swabs were subjected to polymerase chain reaction (PCR) to detect C. trachomatis. A random sample of 359 PCR-positive swabs, stratified by study visit and study community, was chosen for ompA sequencing. In addition, ompA sequencing was performed on all swabs of 24 children who experienced chlamydial re-infection (i.e., positive chlamydial test before treatment, negative test 2 months following mass distribution of azithromycin, and again a positive test 6 months post-treatment). ompA sequencing was successful for 351 of 359 swabs of the random sample and 44 of 48 swabs of the re-infection sample. In the random sample, ompA types clustered within households more than would be expected by chance. Among the 21 re-infected children with complete ompA data, 14 had the same ompA type before and after treatment.

Conclusion

The high frequency of ompA concordance suggests incomplete genovar-specific protective immunity and the need for multiple antigens as vaccine targets.
Lymphatic filariasis in 2016 in American Samoa: Identifying clustering and hotspots using non-spatial and three spatial analytical methods
Authors: Wangdi Kinley , Sheel Meru , Fuimaono Saipale , Graves Patricia M. , Lau Colleen L.
Published: March 2022

Background

American Samoa completed seven rounds of mass drug administration from 2000–2006 as part of the Global Programme to Eliminate Lymphatic Filariasis (LF). However, resurgence was confirmed in 2016 through WHO-recommended school-based transmission assessment survey and a community-based survey. This paper uses data from the 2016 community survey to compare different spatial and non-spatial methods to characterise clustering and hotspots of LF.

Method

Non-spatial clustering of infection markers (antigen [Ag], microfilaraemia [Mf], and antibodies (Ab [Wb123, Bm14, Bm33]) was assessed using intra-cluster correlation coefficients (ICC) at household and village levels. Spatial dependence, clustering and hotspots were examined using semivariograms, Kulldorf’s scan statistic and Getis-Ord Gi* statistics based on locations of surveyed households.

Results

The survey included 2671 persons (750 households, 730 unique locations in 30 villages). ICCs were higher at household (0.20–0.69) than village levels (0.10–0.30) for all infection markers. Semivariograms identified significant spatial dependency for all markers (range 207–562 metres). Using Kulldorff’s scan statistic, significant spatial clustering was observed in two previously known locations of ongoing transmission: for all markers in Fagali’i and all Abs in Vaitogi. Getis-Ord Gi* statistic identified hotspots of all markers in Fagali’i, Vaitogi, and Pago Pago-Anua areas. A hotspot of Ag and Wb123 Ab was identified around the villages of Nua-Seetaga-Asili. Bm14 and Bm33 Ab hotspots were seen in Maleimi and Vaitogi-Ili’ili-Tafuna.

Conclusion

Our study demonstrated the utility of different non-spatial and spatial methods for investigating clustering and hotspots, the benefits of using multiple infection markers, and the value of triangulating results between methods.
The scalability of common paradigms for assessment of cognitive function: A functional transcranial Doppler study
Authors: Intharakham Kannakorn , Panerai Ronney B. , Robinson Thompson G.
Published: March 2022

Cognitive paradigms induce changes in cerebral blood flow (CBF) associated with increased metabolic demand, namely neurovascular coupling (NVC). We tested the hypothesis that the effect of complexity and duration of cognitive paradigms will either enhance or inhibit the NVC response. Bilateral CBF velocity (CBFV) in the middle cerebral arteries (MCAs) via transcranial Doppler ultrasound (TCD), blood pressure (BP), electrocardiogram (ECG) and end-tidal CO2(EtCO2) of 16 healthy participants (aged 21–71 years) were simultaneously recorded at rest and during randomized paradigms of different complexities (naming words beginning with P-,R-,V- words and serial subtractions of 100–2,100–7,1000–17), and durations (5s, 30s and 60s). CBFV responses were population mean normalized from a 30-s baseline period prior to task initiation. A significant increase in bilateral CBFV response was observed at the start of all paradigms and provided a similar pattern in most responses, irrespective of complexity or duration. Although significant inter-hemispherical differences were found during performance of R-word and all serial subtraction paradigms, no lateralisation was observed in more complex naming word tasks. Also, the effect of duration was manifested at late stages of 100–7, but not for other paradigms. CBFV responses could not distinguish different levels of complexity or duration with a single presentation of the cognitive paradigm. Further studies of the ordinal scalability of the NVC response are needed with more advanced modelling techniques, or different types of neural stimulation.
Evaluation of queen cell acceptance and royal jelly production between hygienic and non-hygienic honey bee (Apis mellifera) colonies
Authors: Khan Khalid Ali , Ghramh Hamed A.
Published: March 2022

Honey bees are crucial for pollination services globally and produce important hive products including honey, royal jelly, pollen, and propolis that are being used commercially in food, cosmetics, and alternative medicinal purposes. Among the bee products, royal jelly (RJ) has long attracted scientists’ interest because of its importance in honey caste differentiation. The present research was carried out to determine the acceptance rate of queen cells, and RJ production between the hygienic and non-hygienic lines. Further, this study unveils the effect of pollen substitute diets on the queen cell acceptance rate and RJ yields between both bee stocks. Results showed that the uncapped brood cells and dead brood’s removal percentage was significantly more in hygienic bee colonies in comparison to non-hygienic bee colonies (p < 0.05). The average percentage of larval acceptance was statistically higher in hygienic lines (64.33 ± 2.91%) compared to non-hygienic lines (29.67 ± 1.20%). Similarly, the RJ mean weight per colony differed statistically between both bee stocks (p<0.001), which were 12.23 ± 0.52 g and 6.72 ± 0.33 g, respectively. Moreover, our results demonstrated that a significant difference was observed in larval acceptance rate, RJ yields (per colony and per cup) between both bee stocks those fed on various diets. However, no significant difference was recorded in RJ yields (per colony and per cup) between both bee stock that feeds on either commercially available pollen or pollen substitute. This study may provide future applications in helping bee breeders to choose the bees that carry a higher level of hygienic behavior with high RJ production traits.
Tinjauan Hukum Islam Terhadap Implementasi Akad dan Mekanisme Google Adsense dalam Bisnis Iklan
Authors: Luthfi Ahmad Hashfi , Hidayatullah Abdul Rahman Arif , Dewi Nesfi Nurmiyarti , Saputra Irham Yoga , Shinta Septiana Has
Published: March 2022

This study examines the mechanism of the Google Adsense contract in the advertising business against a review of Islamic law. The purpose of this study is to determine the process of implementing the google adsense mechanism in the advertising business against a review of Islamic law. This type of research uses data collection techniques from several journals obtained during the study by studying matters relating to the use of google adsense in the advertising business against a review of Islamic law. The results of this study indicate that the google adsense contract mechanism in the advertising business against a review of Islamic law reflects the basic values in accordance with the rules of contract law. keywords: Google Adsense; Advertising Business; Islamic Law.
Linking Harare and Johannesburg through Informal Cross-Border Entrepreneurship
Authors:   University of Limpopo, Tawodzera Godfrey , Chikanda Abel ,   University of Kansas
Published: March 2022

Zimbabwe has witnessed a rapid expansion of informal cross border trading (ICBT) with neighbouring countries over the past two and a half decades. That expansion has largely been due to a persistent decline in the economy since the introduction of the Economic Structural Adjustment Programme (ESAP) in the 1990s, which led to the closure of many industries, increased unemployment and forced many people into the informal sector. This 2014 study sought to provide a current picture of ICBT in Zimbabwe by interviewing 514 informal entrepreneurs involved in ICBT between Harare (Zimbabwe) and Johannesburg (South Africa). The sample profile revealed that ICBT in Zimbabwe is dominated by females and young adults and that traders are fairly educated. The study results demonstrate the important role played by ICBT in the survival of households in the country.
Apropiación e impacto de la pedagogía amigoniana por parte de los profesionales en el proceso de reeducación de menores infractores en la Institución Educativa de Trabajo San José
Authors: Zuluaga Mesa David Esteban , Corredor Vargas Luis Eduardo
Published: March 2022

Este artículo da cuenta de cómo los profesionales de la Institución Educativa de Trabajo San José (Bello, Antioquia) perciben, comprenden y vivencian la pedagogía amigoniana en la atención actual de los adolescentes en conflicto con la ley, remitidos por el Sistema de Responsabilidad Penal para Adolescentes en Antioquia. Para ello se realizó una investigación cualitativa de corte fenomenológico, apoyada en una entrevista semiestructurada con preguntas abiertas, a fin de conocer las apreciaciones de los educadores con respecto a cuatro categorías: identidad amigoniana, pedagogía amigoniana, carisma amigoniano y adolescente en conflicto; mediante las cuales se logró contrastar las apreciaciones de los servidores amigonianos con los fundamentos teóricos que sustentan dicha pedagogía. Todo esto sirvió para identificar falencias en el proceso formativo y enunciar estrategias correctivas encaminadas al fortalecimiento de la institución en el cumplimiento de sus objetivos de formación.
Risk factors for damage to the dura mater in thoracic and lumbar spine injury
Authors: Martikyan A. G. , Grin A. A. , Talypov A. E. , Arakelyan S. L.
Published: March 2022

Objective. To clarify a significance of the risk factors for damage to the dura mater (DM) in fractures of the thoracic and lumbar spine.

Material and Methods. The study is based on the analysis of examination data and surgical treatment results of 350 patients with spinal cord injury (SCI). Fractures of the thoracic spine were observed in 124 patients, and those of the lumbar spine in 226. The study included 167 operated patients who underwent posterior decompression at the fracture level using laminectomy and transpedicular fixation of the injured spinal motion segment. There were two groups of patients: study group included 55 patients with DM rupture and control one – 112 patients without damage to the DM.

Results. Damage to the DM was found in 32.9 % of patients, the rupture was localized on the posterior surface of the dural sac. In patients with rupture of the dura mater, ASIA type A and B neurological disorders were significantly more common (p = 0.00065). The DM damage occurs significantly more often in patients with  type C fracture according to the AOSpine classification, with multilevel spinal injuries and combined SCI (Injury Severity Score more than 27.58 ± 9.46 points). The most significant risk factors for the development of DM ruptures are narrowing of the spinal canal at the fracture level by more than 50 %, a fracture of the vertebral arch, an increase in the relative interpedicular distance of more than 20 %, and diastasis between the fragments of the arches by more than 2.5 mm.

Conclusion. The damage to the dura mater is a common complication of vertebral fracture. The prediction of dura mater rupture will allow optimizing surgical approach and improving the treatment outcome.
Factors affecting the formation of bone block in patients with isthmic spondylolisthesis
Authors: Kinzyagulov B. R. , Lebedev V. B. , Zuev A. A.
Published: March 2022

Objective. To analyze significance of the influence of various factors on the fusion rate in patients with isthmic spondylolisthesis.

Material and Methods. A retrospective monocenter study included data from 41 patients aged 18 years and older with isthmic spondylolisthesis who underwent transforaminal interbody fusion with cage using a four-screw rigid transpedicular fixation system. The influence of potential risk factors on the fusion rate was studied.

Results. A univariate analysis showed that obesity (p = 0.037) and the use of non-steroidal anti-inflammatory drugs (NSAIDs) for more than three months (p = 0.007) significantly affect the formation of a bone block. When compiling a logistic regression model, it was found that a combination of obesity, smoking, and the use of NSAIDs for more than three months significantly worsens the prognosis of bone block formation (p = 0.007; R2N = 0.405; AUC = 0.850).

Conclusion. The study showed that the absence of bone block formation in patients with isthmic spondylolisthesis may be associated with smoking, obesity, and the use of NSAIDs for more than three months. Keeping these factors in mind and trying to minimize their presence can help ensure better radiographic outcomes after surgery.
Vitamin supplements enhance Spirulina platensis biomass and phytochemical contents
Authors: Hamouda Ragaa A. , El-Boraey Neveen G. , El Bialy Badr E. , Alrdahe Salma Saleh , Darwish Doaa Bahaa Eldin
Published: March 2022

Spirulina platensis (SP) has a high impact on multidiscipline usage worldwide. Vitamins are considered as growth promoters due to their metabolic bio-regulating roles. This study was conducted to investigate the effect of vitamins: riboflavin (B2), thiamine (B1), and ascorbic acid (C) on SP growth and contents of pigments, phenols, and phytochemicals besides its antioxidant activities. Vitamins were added in different concentrations to Zarrouk’s medium and tested for their effects weekly for three weeks of spirulina cultivation. The results revealed that 25 mg·L−1 thiamine or riboflavin promoted the most significant contents of chlorophyll and carotenoids, respectively, after 14 days of cultivation. However, adding 10 mg·L−1 thiamine achieved the most significant increase in algal biomass yield and contents of chlorophyll, carotenoids phycocyanin, allophycocyanin, phycoerythrin, and phycobiliprotein after 21 days of cultivation. Qualitative analysis showed that both SP and SP supplemented with 10 mg·L−1 thiamine (SPt) for 21 days contain tannins and flavonoids but quantitative analysis approved that SPt recorded significant increase in phenolic and tannin contents. Moreover, SPt induced a significant increase of total antioxidant activity in vitro 1,1-diphenyl-1,2-picrylhydrazyl assay in comparison with SP. Vitamins especially thiamine added during SP culture could improve SP biomasses, pigments, and phytochemical contents and hence increased antioxidant capacity.
A cross-linguistic comparison of the propositional content of laughter in American English and Central Thai
Authors: Hanks Elizabeth
Published: March 2022

Research suggests that laughter can serve several communicative functions beyond indicating mirth, and as such, may hold propositional meaning. The present study analyzes cross-linguistic differences in the propositional content of laughter in American English and Central Thai television shows. A framework for classifying laughter by propositional content was first developed by drawing on existing literature and bottom-up analysis of the laughter found in American English and Thai shows. The framework includes categories of positive valency, negative valency, and humor, along with subcategories of disbelief, support, expressive, and pride. A multi-modal corpus of laughter was then created by compiling all laughter instances in the first 100 min of three American English television shows and three Thai television shows. The meanings of all 848 laughter instances in the corpus were categorized by propositional content of laughter. Results show that humor laughter and negative-support laughter are more frequent in American English, and positive-support laughter and negative-pride laughter are more frequent in Central Thai. These findings provide further evidence that laughter contains propositional content because they indicate that laughter use is subject to cross-linguistic variation that aligns with existing linguistic patterns and cultural values.
Peierls distortion of the cobalt chain in the low-temperature structure of CoIn2
Authors: Gulay Nataliya L. , Kösters Jutta , Kalychak Yaroslav M. , Matar Samir F. , Rabenbauer Alfred , Nilges Tom , Pöttgen Rainer
Published: March 2022

CoIn2 (Z. Metallkd. 1970, 61, 342–343) forms by reaction of the elements at 1470 K followed by annealing at 770 K for five days. The room temperature structure is orthorhombic (CuMg2 type, Fddd, a = 529.95(10), b = 940.49(13), c = 1785.8(3) pm, wR2 = 0.0563, 444 F
2 values, 17 variables) and shows a phase transition at 195(1) K (DSC data). The low-temperature modification crystallizes in the translationengleiche monoclinic subgroup C2/c and exhibits a new structure type (a = 933.7(7), b = 526.91(10), c = 1000.8(2) pm, β = 117.81(5)°, wR2 = 0.0374, 843 F
2 values, 30 variables). The structural phase transition is a consequence of a Peierls type distortion. The equidistant cobalt chains in HT-CoIn2 (270.1 pm, 175.2° Co–Co–Co) show pairwise dislocation in LT-CoIn2 with shorter (252.4 pm) and longer (284.1 pm) Co–Co distances. Each cobalt atom has coordination number 10 in the form of slightly distorted square antiprisms of indium, capped by cobalt on the rectangular faces. Density-of-states calculations reveal metallic behavior for both modifications. Integrated crystal orbital overlap populations featuring the bonding characteristics indicate a slightly higher intensity area for LT-CoIn2 along with a shift to lower energy, manifesting the stabilization by pair formation through Peierls distortion.
Improved Test Methods for Polymer Additive Manufacturing Interlayer Weld Strength and Filament Mechanical Properties
Authors: G. Cole Richard , Fayazbakhsh Kazem , Avalos Abraham , A. Nadeau Nicholas
Published: March 2022

The international community is exploring many potential end uses for polymer additive manufacturing. However, significant issues must be addressed before broad application can occur, in particular understanding the relationships between materials, processes, and final part properties. Key to these issues is having reliable test methods to measure properties of interest. This work used an AON-M2 industrial printer to investigate material extrusion manufacturing. Past research has frequently shown interlayer weld strength (i.e., Z-direction strength) is the weakest property in material extrusion parts and has also shown this property is difficult to measure, with significant data scatter and poor failure modes common for tensile specimens printed vertically. Using acrylonitrile butadiene styrene, the current work investigated in-plane shear testing to interrogate interlayer weld strength based on ASTM D3846, Standard Test Method for In-Plane Shear Strength of Reinforced Plastics, which uses a notched coupon loaded in compression. Further, a modified version of ASTM D3846 was investigated using smaller unnotched “minishear coupons.” Both test methods were found to provide very consistent results, with coefficients of variation of 5% or less; however, the ASTM D3846 notched coupons showed evidence of excessive gage section rotation and interference with the test fixture. The minishear test method did not have this problem and also allowed direct measurement of strain, thereby providing shear modulus. The authors note that in assessing the effect of process on properties, choice of the basis of comparison is important. While many researchers use injection molded properties, the authors believe this is misleading because the injection molding process itself affects properties. Instead, the authors investigated measurement of the polymer filament directly. New methods for filament shear and tension testing were developed that provided good coefficients of variation and allowed direct comparison between three-dimensional printed coupon properties and filament properties in shear.
Means, motive, and opportunity
Authors: Bird Kate I. T. , Nichols Virginia A. , Garay Eduardo S. , Nowatzke Matthew , Essary Ch’Ree , Post Kimberly K. , Deviney Alison V. , Welles Jacqueline S. , Alao Mumuni O. , Dorbu Freda Elikem , Classen John J. , Koziel Jacek A. , Cortus Erin L.
Published: March 2022

Wicked problems are inherent in food–energy–water systems (FEWS) due to the complexity and interconnectedness of these systems, and addressing these challenges necessitates the involvement of the diverse stakeholders in FEWS. However, successful stakeholder engagement requires a strong understanding of the relationships between stakeholders and the specific wicked problem. To better account for these relationships, we adapted a means, motive, and opportunity (MMO) framework to develop a method of stakeholder analysis that evaluates the agency of stakeholders related to a wicked problem in FEWS. This method involves two key components: (1) identification of a challenge at the FEWS nexus and (2) evaluation of stakeholder agency related to the challenge using the dimensions of MMO. This approach provides a method for understanding the characteristics of stakeholders in FEWS and provides information that could be used to inform stakeholder engagement in efforts to address wicked problems at the FEWS nexus. In this article, we present the stakeholder analysis method and describe an example application of the MMO method by examining stakeholder agency related to the adoption of improved swine waste management technology in North Carolina, USA.
C/EBPβ mediates anti-proliferative effects of 1,25(OH)2D on differentiated thyroid carcinoma cells
Authors: Xu Feng , Ling Yali , Yuan Jingjing , Zeng Qin , Li Lusha , Dai Dexing , Xia Xuedi , Sun Ruoman , Zhang Ran , Xie Zhongjian
Published: March 2022

Differentiated thyroid carcinoma (DTC) is the most common endocrine malignancy and highly expresses the receptor for 1,25-dihydroxyvitamin D (1,25(OH)2D). However, it is unclear whether 1,25(OH)2D regulates DTC proliferation and differentiation. Here, we found that 1,25(OH)2D3 inhibited proliferation but not differentiation of the DTC cells. Notably, CYP27B1was elevated in DTC cells and 25-hydroxyvitamin D3 (25(OH)D3) reduced DTC cell proliferation. Knockdown of VDR did not affect the anti-proliferative effects of 1,25(OH)2D3. However, knockdown of CCAAT enhancer-binding protein β (C/EBPβ)abolished 1,25(OH)2D3-suppressed DTC cell proliferation. In addition, 1,25(OH)2D3 induced phosphorylation and translocation of C/EBPβto the nucleus from the cytoplasm. However, inhibition of p38 mitogen-activated protein kinases (MAPK) abrogated 1,25(OH)2D3-induced phosphorylation and nuclear translocation of C/EBPβas well as 1,25(OH)2D3-suppressed DTC cell proliferation. Knockdown of C/EBPβreduced the expression of Notch3. Knockdown of Notch3 blocked 1,25(OH)2D3-suppressed DTC cell proliferation. In the DTC cell-derived xenograft SCID mouse, knockdown of C/EBPβmarkedly increased tumor growth and proliferation and decreased apoptosis. In DTC patients, C/EBPβwas predominantly located in the cytoplasm of DTC cells in the tumor tissue when compared with adjacent non-cancerous tissue in which C/EBPβis located in the nucleus. In conclusion, C/EBPβstimulated Notch3signaling via the p38 MAPK-dependent pathway mediates the inhibitory effect of 1,25(OH)2D on DTC cell proliferation.
Una aproximación reflexiva a la crisis del multilateralismo frente al paradigma de la lucha contra el narcotráfico y el desarrollo sostenible: ¿la erradicación de cultivos ilícitos en Colombia y Perú como paradigma alternativo?
Authors: Devia Garzón Camilo Andrés , Ortiz Morales Catherine
Published: March 2022

Este trabajo tiene como objetivo analizar y reflexionar sobre la actual crisis del multilateralismo y sus principios generales de conducta —ideas, discursos y prácticas—, lo que puede representar un escenario de oportunidades y amenazas para responder a la complejidad del problema mundial de drogas y la crisis de su paradigma dominante cuya estrategia, primordialmente militar, representa una visión de mundo anacrónica respecto a la seguridad reducida a un enfoque prohibicionista. Así mismo, tienen lugar los debates sobre el paradigma dominante de desarrollo, construido desde los acuerdos globales y sus principios generales de conducta —ideas— que han determinado y constreñido un enfoque multidimensional en el caso de Colombia y Perú. De esta manera, la visión de mundo ha estado determinada por la visión dialéctica del mundo interno —armonía— y externo —anarquía— de acuerdo con los enfoques racionalistas que, a partir de la crítica de los enfoques reflexivos en las Relaciones Internacionales, se plantea más que una explicación (causalidad), la compresión (interpretación) y co-constitución de la realidad y los fenómenos actuales, como el problema mundial de drogas y el desarrollo para la consolidación de paradigmas alternativos en Colombia y Perú.
La poética de la germinación cultural o la representación del sujeto andino desde los elementos paratextuales en Falo (1926)
Authors: Díaz Vargas Alex
Published: March 2022

El vanguardismo literario peruano se caracterizó por construir un discurso revulsivo que cuestionó al aparato de Gobierno y a los discursos hegemónicos de su época. En el poemario Falo (1926) del poeta puneño Emilio Armaza (1902-1980), se percibe este mecanismo en dos instancias. Por un lado, a partir de la representación de un sujeto lírico andino, busca anular la condición de objeto del indígena porque su figura cobra protagonismo dentro de la escena cultural. A su vez, sobre la base de una dinámica dialéctica, este entra en tensión con los sujetos hegemónicos. Por otro lado, al visibilizar sus prácticas culturales y concebirlas en constante germinación, establece una forma de resistencia cultural frente a la violencia simbólica y fáctica ejercida en su contra. Mediante el análisis de los paratextos se buscará demostrar que esta estrategia poética que Armaza ejecuta persigue el objetivo de restituir la condición humana del hombre andino y legitimar la universalidad de su cultural.
Espino Relucé, Gonzalo. De ese hombre que dicen. Lima: Pakarina Ediciones. 2018, 84 pp.
Authors: Álvarez Rolando
Published: March 2022

De ese hombre que dicen, poemario de Gonzalo Espino Relucé, estructurado en cinco bloques: “Moradía”; “Micma”; “Tulape”; Río arriba, monte abajo” y “Escribas”. Reitera la vocación del autor por la fuerza de la palabra poética como un elemento capaz de construir un puente, colgante tal vez, entre la realidad insondable de la persona y su entorno histórico, temporal; entre eso que Antonio Machado llamaba “las galerías subterráneas del alma” y la “circunstancia” que conceptualizó Ortega y Gasset.
Geografia derivada
Authors: Antunes Marcelo Da Silva
Published: March 2022

[Sin resumen]
Sign-changing solutions for Kirchhoff-type problems involving variable-order fractional Laplacian and critical exponents
Authors: Liang Sihua , Molica Bisci Giovanni , Zhang Binlin
Published: March 2022

In this paper, we are concerned with the Kirchhoff-type variable-order fractional Laplacian problem with critical variable exponent. By using constraint variational method and quantitative deformation lemma we show the existence of one least energy solution, which is strictly larger than twice of that of any ground state solution.
THE RELATIONSHIP OF FATHER'S INVOLVEMENT IN PARENTING AND INTERPERSONAL INTELLIGENCE OF YOUNG CHILDREN
Authors: Verani Merta , Somad Abdus , Warmansyah Jhoni
Published: March 2022

The involvement of fathers in parenting is an interesting discussion today. Many research show positive impacts of fathers' interactions in parenting on child development. The reality in Jakarta is that fathers work full time all day, and many fathers still think that child management is the mother's duty. This study aimed to see how the relationship between the father's interaction in parenting and the child's interpersonal intelligence. This study used a sample of 115 fathers, and children were collected using a simple random sampling technique. The research method used is correlational. The instrument was a questionnaire compiled independently and distributed to the father to measure the father's interactions in parenting in the form of a Likert scale, interpersonal intelligence measured through a multiple intelligence instrument (Jamaris, 2018). Based on data analysis using Pearson's current product trials, the researcher found that trust (rxy) was 0, 509 with p = 0.000 (p <0.001). Thus, it can be stated that the higher the father is involved in parenting, the better the level of development of the child's interpersonal intelligence. The role of fathers in parenting is significant in child development, especially in developing multiple intelligence possessed by children.
On the Movement of Gyrostat under the Action of Potential and Gyroscopic Forces
Authors: Kosov Alexander A. , Semenov Eduard I.
Published: March 2022

A system of differential equations is considered that describes the motion of a gyrostat under the action of the moment of potential, gyroscopic and circular-gyroscopic forces. The form of the moment of forces is indicated for which the system has the three first integrals of a given form. An analog of V.I. Zubov’s theorem for representing solutions of gyrostat equations by power series is given, and the possibility of using this approach to predict motions is shown. For an analogue of the Lagrange case, integration in quadratures is performed. Analogues of the case of full dynamical symmetry and the Hess case are also indicated. Based on the principle of optimal damping developed by V.I. Zubov, a design of the control moment created by circular-gyroscopic forces is proposed, which ensures that one of the coordinates reaches a constant (albeit unknown in advance) value or the transition of the state vector to the level surface of the particular Hess integral. A numerical example is given, for which a two-parameter family of exact almost periodic solutions, represented by trigonometric functions, is found.
A new species of Lepanthes (Orchidaceae: Pleurothallidinae) with rabbit ear-like petals endemic to Colombia
Authors: Restrepo Eugenio , Vieira-Uribe Sebastián , Moreno Juan Sebastián , Baquero Luis E.
Published: March 2022

A new species of Lepanthes from the department of Antioquia apparently restricted to the north-central Andes of Colombia is described and illustrated. The new species is similar to L. alcicornis; however, it can be easily distinguished by the transversally lobulate petals that resemble the ears of a rabbit, the reniform lip with sub-oblong basal lobes surrounding the column, and the absence of an appendix on the lip.
DAKWAH DIALOGIS-BERKEARIFAN TERHADAP PURIFIKASI DAN SINKRETISASI TRADISI BAKAR KEMENYAN DAN BALIMAU
Authors: Yanti Fitra , Wimra Zelfeni
Published: March 2022

This article discusses the dynamics of purification and syncretization of the tradition of burning incense and balimau in the Minangkabau community. The aim is to explain how the dialogic-wise pattern of da'wah is against local traditions or wisdom. The method used is critical discourse analysis of the dominance of purification and syncretization discourses in da'wah. The temporary conclusion is that the pattern of preaching which should be dialogic-wise is still interpreted as a stage of purification of practices that are claimed to be syncretic. The implication is that dialogic-wise preaching becomes one of the da'wah patterns that can be mainstreamed in understanding the plurality of cultures and traditions.
BENTUK HUBUNGAN MASYARAKAT (PUBLICITY) PONDOK PESANTREN ANDALUSIA KECAMATAN PAUH DUO KABUPATEN SOLOK SELATAN
Authors: Zulvianti Nora , Noviyanti Asri
Published: March 2022

Promotion is one part of a series of marketing activities for a product. Promotion is an effort to introduce a product to potential buyers. Promotion has several components, one of which is public relations. Public relations carried out by the Andalusian Islamic Boarding School, Pauh Duo District, South Solok Regency are still not optimal. The purpose of this study was to describe the community relations carried out by the Andaluisa Islamic Boarding School, Pauh Duo District, South Solok Regency. This research is a field research. The method used is a qualitative method. This type of research is descriptive. The findings of this study are that the Andalusian Islamic Boarding School, Pauh Duo District, South Solok Regency has carried out promotions in the form of public relations.
KEEFEKTIFAN PENDEKATAN POLYA QUESTIONING INSTRUCTION UNTUK MENINGKATKAN KEMAMPUAN PENALARAN GEOMETRIS SISWA
Authors: Mardika Fitria , Hasanah Rusi Ulfa
Published: March 2022

AbstrakTujuan penelitian ini adalah untuk mengetahui keefektifan pembelajaran matematika dengan pendekatan Polya Questioning Instruction (PQI) untuk meningkatkan kemampuan penalaran geometris siswa kelas VIII SMP Negeri 5 Yogyakarta. Pembelajaran matematika dengan pendekatan PQI ini menggunakan model problem solving dengan strategi pemberian pertanyaan (questioning). Pertanyaan-pertanyaan yang diberikan bertujuan untuk mengarahkan siswa berpikir dan bernalar untuk menyelesaikan masalah sesuai dengan langkah pemecahan masalah Polya yaitu (1) memahami masalah (understanding the problem), (2) merencanakan cara penyelesaian (devising a plan), (3) melaksanakan rencana (carrying out the plan), dan (4) melakukan pengecekan kembali terhadap semua langkah yang telah dikerjakan (looking back).Desain penelitian untuk memperoleh data mengenai kemampuan penalaran geometris siswa menggunakan bentuk pra-experimental design yang digunakan adalah One-Shot Case Study dimana suatu kelompok diberi perlakuan kemudian diukur hasilnya. Populasi dalam penelitian ini adalah siswa kelas VIII SMP Negeri 5 Yogyakarta. Sampel penelitian adalah 32 orang siswa kelas VIII.7 SMP Negeri 5 Yogyakarta yang telah memiliki kemampuan awal yang cukup untuk mempelajari konsep.Instrumen yang digunakan pada penelitian ini adalah soal tes kemampuan penalaran geometris. Pendekatan PQI efektif apabila persentase siswa yang memenuhi ketuntasan secara klasikal pada tes kemampuan penalaran geometris minimal mencapai 75%, dan proporsi siswa yang telah mencapai skor kemampuan penalaran geometris minimal kategori tinggi mencapai lebih dari atau sama dengan 75%. Hasil tes kemampuan penalaran geometris siswa menunjukkan bahwa pendekatan PQI efektif untuk meningkatkan penalaran geometris siswa. Hal ini dikarenakan persentase siswa yang mencapai KKM pada tes kemampuan penalaran geometris adalah 75%. Berdasarkan uji hipotesis dengan taraf signifikansi 5%, diperoleh kesimpulan bahwa proporsi siswa mencapai kategori minimal tinggi lebih dari atau sama dengan 75%. Kata kunci: Polya Questioning Instruction, Questioning, Penalaran Geometris
AKTIVITAS BELAJAR DAN PEMAHAMAN KONSEP MATEMATIKA SISWA MENGGUNAKAN MODEL PEMBELAJARAN KOOPERATIF TIPE THINK TALK WRITE DI KELAS XI MIPA SMA N 5 BUKITTINGGI TAHUN PELAJARAN 2019/2020
Authors: Rahmah Novetri , Imamuddin M , Rahmat Tasnim
Published: March 2022

This research is motivated by the lack of student activity in the learning process and the low ability to understand students' mathematical concepts. This is contrary to learning that is still conventional in nature, namely the learning process issued by the teacher. To overcome this problem, the Think Talk Write (TTW) cooperative learning model is applied. Mathematics learning for students who learn to think to talk cooperative learning models (TTW) and understanding mathematical concepts who learn think to talk cooperative learning models (TTW) are better for those looking for conventional learning. This type of research is a pre-trial research design that is the Static Group Comparison Design. The population in this study were all class XI MIPA. The sample in this study was class XI MIPA 2 as an experimental class and class XI MIPA 1 as a control class. The instrument used in the study was an observation sheet and a concept understanding test consisting of essay tests. Data obtained from the results of the study concluded that student activity with the cooperative learning model think talk writes (TTW) was 69.75%, so the activity was classified as active. Based on data analysis using t-test, it can be denied that "The ability to understand the mathematics of students who use the cooperative learning model of the type of think talk write (TTW) is better than conventional learning in class XI MIPA SMA N 5 Bukittinggi 2019/2020 academic year".
PENGUKURAN KINERJA DAN AKUNTABILITAS PENDIDIKAN
Authors: Sukatin Sukatin , Nasution Fitri
Published: March 2022

Measuring teacher performance is an important part of the educational management control process, both public and private education organizations. However, because the nature and characteristics of public education sector organizations differ from those of the private sector, such performance must be measured and reported in the form of a performance report. There are also differences in the emphasis and orientation of performance measurement. The objectives of the performance appraisal in the public sector are: Knowing the level of achievement of educational organizational goals, providing learning facilities for educational personnel, improving the performance of education personnel for the next period, providing systematic consideration in making decisions about giving rewards and punishments to educational personnel, motivating educational staff, creating accountability for educational organizations.
ANALISIS KEBIJAKAN PENDIDIKAN NO. 2 TAHUN 2017 TENTANG PENGEMBANGAN DAN PENINGKATAN PROFESI GURU
Authors: Sriwahyuni Eci , Amelia Mita
Published: March 2022

Teachers play an important and very strategic role in the framework of carrying out functions and realizing national education goals. The role of the teacher can hardly be replaced by others, especially in a multicultural and multidimensional society. Therefore, the coaching and development of the teaching profession must always be a top priority. This study aims to analyze educational policies related to the development and improvement of the teaching profession. The research method used in this study is a qualitative method with a literature study approach. The data taken in this study came from various library sources related to the study of this discussion, then the data was processed using qualitative descriptive analysis techniques, which is a way of processing data that is formulated in the form of words or data interpretation. The results of this study indicate that with the existence of educational policies regarding the development and improvement of the teaching profession, the position of teachers is increasingly being shaded by clear legal sources and teachers become more knowledgeable and professional as teachers.
HUBUNGAN LAYANAN PERPUSTAKAAN TERHADAP MINAT BACA PESERTA DIDIK DI SMK ADZKIA PADANG
Authors: Yuliana Sartika , Hasnawati Hasnawati , Hasnah Radhiatul
Published: March 2022

This research is motivated because the motivation of learners to read is very lacking, most of the learners go to the library because they are lazy to learn and just to take off, or sleep. The problem limitation of this study is (a) library service in SMK Adzkia Padang (b) reading interest of  learners in SMK Adzkia Padang (c) the relation of library services to the interest of reading learners in SMK Adzkia Padang. This research aims to find out a positive relation between library services to the reading interests of learners in Smk Adzkia Padang. The hypothesis proposed is that there is a positive relationship of library services to the reading interest of learners in SMK Adzkia Padang. In this study there are two variables, namely free variables (library services) and bound variables (reading interest of learners). This research is field research using a quantitative approach. This research method uses correlational methods. The population in this study was 68 learners and the sample number of 68 learners was taken using total sampling techniques. Research instruments use 2 (two) questionnaires, namely qustionnaire about library service and reading interest of learners. The data is processed using the Statistical Product and Service Solution (SPSS) Program version 20.00, and analyzed using the formula Product Moment Correlation Coeffisien Karl Pearson. The results showed that from pearson correlation results at rxy =0.585 greater than r tabell for 1 % = 0.325 and 5% = 0.250, thus Ha accepted and H0 rejected, meaning there isa positive connecting between library services and the reading interest of learners in Smk Adzkia                          Padang. And from the results of Pearson Correlation at calculated r = 0.585 can see the level of  the relationship in the classification of correlation numbers, 0,585 located between 0.40 to 0.599 with the level of corelation.
Relationship of lipid metabolism disorders with the development of fatal and non-fatal cardiovascular events in residents of the Chui region of the Kyrgyz Republic of varying sex and ethnicity
Authors: Polupanov A. G. , Mamatov A. U. , Kontsevaya A. V. , Duishenalieva M. T. , Khalmatov A. N. , Bebezov I. Kh. , Akhunbaev S. M. , Sabirov I. S. , Dzhumagulova A. S.
Published: March 2022

Aim. To study the relationship of lipid metabolism disorders (overweight, general and abdominal obesity (AO)) with the development of fatal and non-fatal cardiovascular events (CVEs) among residents of the Chui region of the Kyrgyz Republic of varying sex and ethnicity.

Material and methods. This study was performed as part of the international prospective epidemiological project “Interepid”. The total follow-up period was 7 years. Vital status at the end of the follow-up period was monitored in 1096 respondents from 1341 initial cohorts. Response rate was 82,1%. As an endpoint, the analysis included cases of fatal and non-fatal CVEs. The prevalence of events was assessed by survival analysis methods (Cox proportional hazard regression model, parametric survival models, Kaplan-Meier estimator).

Results. In total, 181 (16,44%) cases of fatal and non-fatal CVEs were recorded during the follow-up period. In individuals with normal body weight, the incidence of CVEs was 10%. In overweight persons, it increased and reached 17,99% (p<0,001), while in those with obesity — 24,5% (p<0.0001). An increase in CVE rate with an increase in body mass index was recorded in all analyzed subgroups (men, women, Russians, Kyrgyz). Cox regression model with a logistic regression analysis made it possible to confirm the independent role of general and AO in the development of fatal and non-fatal cardiac and cerebral accidents in both ethnic groups in women, but not in men.

Conclusion. An increase in body mass index >25 kg/m2 and the presence of AO are independent risk factors for fatal and non-fatal CVEs in the analyzed cohort of residents of the Chui region in women (but not men) of both ethnic groups.
Inflammatory continuum in the pathogenesis of atrial fibrillation after coronary bypass surgery
Authors: Mingalimova A. R. , Drapkina O. M. , Sagirov M. A. , Mazanov M. Kh. , Bikbova M. M. , Argir I. A.
Published: March 2022

Atrial fibrillation (AF) after coronary bypass surgery is recorded in 20- 60% of patients and increase the early and long-term postoperative mortality. The aim of the review is to analyze the studies on causal relationships between damaging factors and the development of myocardial inflammation at each stage of surgical treatment in patients with multivessel coronary artery disease. In the review, myocardial inflammation is considered from the point of view of a continuum  — a chronic process that originates from the coronary endothelium damage and continuously proceeds within the AF pathogenesis after coronary bypass surgery. For the first time, the concept of inflammatory continuum for postoperative AF is introduced. The review discusses the main and latest laboratory and instrumental markers of local and systemic inflammatory response, which are informative in terms of severity and promising for improving approaches to the diagnosis and prevention of postoperative AF. The review was prepared using available materials from Russian and foreign library databases (PubMed, Medline, Web of Science and Cochrane Library). The search depth was >25 years since 1996. Based on the analysis of available studies, we concluded that inflammation is not just evidence of AF, but plays a causal role in its pathogenesis at each stage of surgical myocardial revascularization.