bluuebunny/crossref_metadata_2025 huggingface dataset:
RECONFIGURANDO CONFIGURAÇÕES – O USO DO TABLET EM ATIVIDADES ARTETERAPÊUTICAS
Authors: Wosiack Raquel Maria Rossi , Da Cunha Gilson Luis , Bassani Patrícia Brandalise Scherer , Barbosa Débora Nice Ferrari , Santos Geraldine Alves dos
Published: November 2017

A utilização do computador em contextos educacionais, constitui-se em um desafio. Propomos que o cenário terapêutico também se utilize destes recursos. Este artigo relata experiências desenvolvidas na Associação em Oncopediatria em Novo Hamburgo/RS. O objetivo desta pesquisa foi avaliar a utilização da ferramenta tablet na possibilidade de expressão da criatividade de mães e avós cuidadoras de crianças com câncer. O presente estudo apresentou um delineamento qualitativo e constituiu-se em uma pesquisa intervenção. Participaram do estudo treze mães e avós que exercem o papel de cuidadoras. Utilizaram-se como instrumentos as produções expressivas realizadas pelas mães/avós, suas falas e o diário da arteterapeuta. Utilizou-se a análise de conteúdo de Bardin. Constatou-se que as participantes beneficiaram-se do processo, expressaram seus sentimentos e vivências, reconfigurando suas próprias criações através do processo híbrido, que consiste na junção de duas ou mais formas de expressão em um mesmo trabalho.
A UTILIZAÇÃO DA CASCA DA BANANA COMO SUBSTITUIÇÃO DE PARTE DO CIMENTO NA PRODUÇÃO DE TIJOLOS ECOLÓGICOS: A busca por alternativas sustentáveis
Authors: Silva Diego , Aquiar Mateus Bravo , Jacob Raquel Sampaio
Published: November 2017

Esta pesquisa consiste no estudo das propriedades do tijolo confeccionado a partir do pó da casca de banana, suas características quanto à resistência e sua incorporação como alternativa sustentável na construção civil.Foi utilizadosolo tipo argila-arenosa e o cimento CPIIZ-32 provenientes das imediações do laboratório de ensaios e campo da Pontifícia Universidade Católica de Minas Gerais (PUC minas) e as cascas de bananas coletadas do restaurante popular do Barreiro em Belo Horizonte para a moldagem dos corpos de prova. Os métodos utilizados para avaliar o comportamento destes tijolos foram feitos a partir de ensaios de compressão simples e absorção de água. Para a determinação da mistura de solo-cimento foram estudados dois teores de resíduos da casca da banana (2 % e 4%), sendo confeccionados 18 corpos-de-prova ao todo, 6 para cada formulação, incluindo a de solo cimento, nas idades de 7 e 14 dias. Os resultados dos ensaios tecnológicos foram comparados de acordo com as normas da ABNT- Associação Brasileira de Normas Técnicas.
PROJETO DE APROVEITAMENTO DA ÁGUA DE CHUVA PARA O USO NÃO POTÁVEL DOMICILIAR
Authors: Cocco Giangiulio Pietro Reis , Almeida Guilherme Henrique Leite de , Lupp Lucas Sampaio Luiz , Jacob Raquel Sampaio , Bodevan Renan Igor , Barbosa Renata Karla Reis Campos , Sales Valquiria Da Silva Leão
Published: November 2017

Em virtude da crise hídrica vivenciada na atualidade, a adoção de práticas que visam a economia de água tem sido preconizadas. De fato, localidades que nunca haviam se deparado com a ausência de água tiveram que, repentinamente, alterar os seus hábitos. Desse modo, abriu-se o leque para o desenvolvimento de soluções que reduzissem o consumo de água, ou que aproveitassem recursos disponíveis, os quais eram dispensados anteriormente, como por exemplo, a água da chuva. Em suma, este artigo apresenta o desenvolvimento de um projeto para a captação, tratamento e reservação da água da chuva para uma residência unifamiliar localizada na região do Barreiro, na cidade de Belo Horizonte, Minas Gerais, visando o uso não potável da água a ser reaproveitada. Adicionalmente, far-se-á uma comparação de custos entre o sistema convencional e o sistema de aproveitamento da água de chuva. A proposta apresenta expressivo potencial na redução do consumo de água potável, mantendo assim seu foco ambiental.
DESENVOLVIMENTO DE PEÇAS MOLDADAS EM POLÍMEROS PARA PRODUTOS DA INDÚSTRIA DE BALAS DE GOMA
Authors: De Oliveira Everaldo Fernandes
Published: November 2017

Esta pesquisa foi motivada pelas dificuldades de se conseguir peças de reposição dos formatos de produtos que eram fabricados em alumínio e gesso por fornecedores nacionais e internacionais para uma indústria de balas de goma, e também devido a problemas como prazo de entrega, custo alto e falhas de fabricação. Devido as dificuldades relatadas foram realizadas pesquisas para inserir materiais não convencionais para o setor e internalizar o processo de fabricação das peças dos formatos. Para atingir o objetivo foi inserido a usinagem em fresadora CNC para a confecção de matrizes dos formatos das peças e também foi aplicado o processo de moldagem por vazamento com pressão positiva e realizado posterior análise da melhor temperatura de cura. Como resultado obteve-se peças de reposição dos formatos fabricadas com bi-componentes de poliuretano. Como conclusão verificou-se que a temperatura ambiente influencia no tempo de cura e na dureza das peças fabricadas. Também verificou-se uma redução no custo das peças fabricadas em poliuretano comparando com peças adquiridas em alumínio e gesso além da garantia de confidencialidade no desenvolvimento de novas peças de formatos.
Discalculia: Um Mapeamento de Artigos Brasileiros
Authors: Avila Lanúzia Almeida Brum , Lara Isabel Cristina Machado de
Published: November 2017

Este artigo apresenta o mapeamento teórico de artigos que abordam a temática Discalculia, transtornos de aprendizagem em Matemática (TAM) e dificuldades de aprendizagem em Matemática (DAM) publicados em periódicos acadêmicos brasileiros. Tem como objetivo verificar o estado da arte dessas produções, buscando por suas convergências e divergências em relação a alguns aspectos, entre eles o modo como são conceituados os termos Discalculia, TAM e DAM e as contribuições aos profissionais da área da Educação. Para selecionar as produções brasileiras dos últimos anos, utilizou-se o banco de periódicos disponibilizados pela Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) e a Scientific Eletronic Library Online (SCIELO). A análise evidencia que os artigos divergem quanto aos termos adotados na literatura para referir-se às dificuldades de aprendizagem (DA) e aos transtornos de aprendizagem (TA), fazendo uso não somente do termo Discalculia, como também DAM, TAM e distúrbios de aprendizagem, o que acaba por dificultar a comparação entre os dados pesquisados, pela falta de padronização quanto as denominações utilizadas. 
O Conhecimento Pedagógico e a Integração das Tecnologias de Informação no Ensino de Quadriláteros
Authors: De Almeida Janaina Xavier , Mathias Carmen Vieira
Published: November 2017

Com o estudo proposto, objetivou-se analisar e compreender as concepções matemáticas dos professores e, a partir disso, proporcionar oportunidades de introduzir a utilização das Tecnologias de Informação e Comunicação (TIC) como ferramentas auxiliares na prática docente, no ensino de quadriláteros. Essa compreensão utilizou como subsídios teóricos os Saberes Docentes, os conhecimentos do conteúdo específico e o conhecimento tecnológico e pedagógico do conteúdo. A pesquisa foi desenvolvida em duas etapas. Na primeira,foram realizadas entrevistas e aplicados questionários aos professores, atuantes nos anos iniciais do Ensino Fundamental, na rede Pública de um município do Rio Grande do Sul. Na segunda etapa, foi organizada uma Oficina de Formação Continuada, oferecida aos professores pesquisados. A partir da análise e discussão das etapas, constatou-se que os sujeitos da pesquisa se mostraram conscientes da importância do ensino de quadriláteros e do uso de TIC nos anos iniciais do ensino fundamental. Entretanto, essa consciência esbarra em dificuldades decorrentes da sua formação inicial e continuada.
O papel do exílio na configuração do nacionalismo de Gonçalves Dias
Authors: Lima Renata Ribeiro
Published: November 2017

 

Resumo: Este trabalho propõe uma breve passagem pela biografia e pela obra do poeta Gonçalves Dias, com ênfase nos textos em que trata do exílio, analisando-os à luz de estudos sobre o Exílio e dos Estudos Pós-coloniais. Investiga-se a maneira como os sucessivos exílios a que foi submetido o poeta afetaram a sua forma de perceber e de atribuir valores aos lugares. Verifica-se como, nas representações do nacional em Gonçalves Dias, construídas a partir do duplo olhar do exilado, materializam-se conflitos de identidade, cruzando-se olhares do colonizado e do colonizador num amálgama de que era testemunha viva a própria pessoa do poeta.

Palavras-chave: Exílio. Identidade. Consciência exílica. Romantismo. Nacionalismo.
INVESTIGATION OF SOLID PHASE BEHAVIOR DURING PROCESS OF ACIDIC DECOMPOSITION OF POLPINO PHOSPHORITE
Authors: Pochitalkina Irina A. , Syromyatnikov Aleksandr S. , Kondakov Dmitriy F. , Makaev Sergey V.
Published: November 2017

The deficiency and growing price of phosphate fertilizers are becoming a major problem in Russia. Most of more than 200 proved phosphorite deposits have enough recourse to exploit them but processing the ore from these deposits presents severe difficulties, and it can’t be effectively implemented at this moment. The result of the decomposition process heavily depends on the origin of the ore, their chemical and mineralogical composition and other factors. Three types of phosphorites (carbonated, siliceous, and argillaceous) can be distinguished, and these types of phosphorites behave differently during the acidic decomposition, which leads to the differences in the conditions and performances in the process of their treatment. Phosphorite from Polpino deposit can be considered poor with total component content P2O5≈15.3%, and by the level of SiO2 it can be qualified as siliceous type. The stock from this deposit is highly reactive because of the carbonated additions and its mineral structure. The aim of the research is to study the dynamics of particle shape and size change during the acidic decomposition of a representative quartered sample of Polpino phosphorite. The decomposition was performed using nitric acid with temporary inhibition of the reaction at 0, 10, 30, 60, 300, 600 seconds by neutralization of acid with potassium hydroxide. Solid phase behavior was investigated using microscopic analysis (scanning electronic microscopy) with multi-purpose module microscope JEOL JSM-6510, and then obtained micrographs were edited with special software. Analysis of the behavior of the particles shows that their total number was nearly constant for each experiment, and the number of particles for every fraction almost didn’t change in time. This leads to assumption that the phosphate component in phosphorite from Polpino deposit is located inside of the porous alpha-quartz. It was determined that alpha-quartz from the phosphorite forms a matrix structure and doesn’t undergo changes, and its pore size doesn’t prevent acidic extraction of calcium and phosphate from the inner volume.Forcitation:Pochitalkina I.A., Kondakov D.F., Syromyatnikov A.S., Makaev S.V. Investigation of solid phase behavior during process of acidic decomposition of polpino phosphorite. Izv. Vyssh. Uchebn. Zaved. Khim. Khim. Tekhnol. 2017. V. 60. N 10. P. 47-52
ОПТИМАЛНA ЛОКАЦИЈA СЛОБОДНИХ ЗОНА И НОВА ЕКОНОМСКА ГЕОГРАФИЈА
Authors: Ерић Огњен , Лојовић Милимир
Published: November 2017

Простор као центар теоријских мишљења у економији долази до изражаја крајем 90-их година прошлогвијека, појавом Нове економске географије (New Economic Geography – NEG). Представници ове теорије сматрајуда је подручје економске географије дуго занемаривано због потешкоћа са њеним формализовањем. Стварањеекономских активности у простору полази од хипотезе о постојању растућих приноса на обим производње.Да би се производња концентрисала на одређеном мјесту, неопходно је да простор буде релевантан изворекономских активности. Без постојања растућих приноса произвођачи су индиферентни у избору локације запокретање производње, а економско моделовање простора губи смисао. Растући приноси подстичу произвођачеда се просторно концентришу на локације гдје се они и остварују. Као облик просторног смјештаја економскихфункција, слободне зоне су у директној вези са просторном економијом. Слободне зоне су фактор концентрацијеекономске активности у простору. У раду се анализира теорија Нове економске географије и избор оптималнелокације слободних зона кроз моделовање транспортних трошкова (прорачун удаљености од центра економскеактивности). Транспортни трошкови су незаобилазан фактор у моделима теорије Нове економске географије, алии фактор смјештајне оптималности слободних зона. Дакле, трошкови транспорта представљају фактор рализацијеекономије обима и растућих приноса у слободним зонама.
НЕЗАПОСЛЕНОСТ СТАНОВНИШТВА РЕПУБЛИКЕ СРПСКЕ – ПРОСТОРНО-ДЕМОГРАФСКЕ КАРАКТЕРИСТИКЕ
Authors: Станивук Саша , Маринковић Драшко
Published: November 2017

Незапосленост је један од кључних друштвених проблема са којим се сусреће Република Српска. Занезапослена лица у свим земљама свијета незапосленост је веома тешко и понижавајуће стање, а за друштвои државу неискориштени ресурс. У случају Републике Српске рјешевање проблема незапослености је посебноважно јер су људски ресурси којима она располаже све мањи. Број њених становника већ више од десет годинанепрестано се смањује као посљедица негативног природног прираштаја и негативног миграционог салда.Јасно је да негативне вриједности ова два демографска показатеља у дужем периоду неминовно утичу настаросну структуру становништва, тј. на демографско старење земље и смањење броја и удјела радно способногстановништва, што узрокује оптерећење социјалних фондова и читав низ негативних економских посљедица.
ТРЕНДОВИ ИНДЕКСА ЕКСТРЕМНИХ ТЕМПЕРАТУРА У БОСНИ И ХЕРЦЕГОВИНИ ‒ ПРИМЈЕР МОСТАРА
Authors: Попов Татјана , Гњато Слободан , Трбић Горан
Published: November 2017

У раду су анализирани трендови индекса екстремних температура у Босни и Херцеговини. Дневнеминималне и максималне температуре у периоду 1961‒2016. године са метеоролошке станице Мостар (којије изабран за студију случаја) коришћене су за израчунавање 18 индекса употребом RClimDex (1.0) софтвера.Максималне и минималне температуре показују тенденцију раста током цијеле године. Позитивни трендовитоплих температурних индекса израженији су од опадајућих трендова хладних температурних индекса. Међутим,оба тренда указују да је на овом подручју присутно загријавање климатског система. Осмотрени трендовинајизраженији су у сезони љето, затим у сезонама прољеће и зима. Утврђена је значајна позитивна/негативнакорелација између Источно-атлантске осцилације и топлих/хладних температурних индекса током цијелегодине. Зимске и прољећне температуре такође су повезане са Сјеверно-атлантском и Арктичком осцилацијом,респективно.
The Impact of Postoperative Percent Change of Parathormone Level From Baseline Value on the Rate of Hypocalcemia After Total Thyroidectomy
Authors: Sormaz Ismail C. , Iscan Ahmet Y. , Ozgur Ilker , Karakus Seyma , Tunca Fatih , Senyurek Yasemin G. , Terzioglu Tarik
Published: November 2017

Background

The purpose of this study was to investigate the impact of the percent change of postoperative parathormone (PoPTH) level from baseline value (ΔPTH) on the rate of hypocalcemia after total thyroidectomy.

Methods

Assays of serum PTH and calcium (Ca) were performed preoperatively and at 24 hours postoperatively in 222 consecutive patients who underwent total thyroidectomy. Postoperative hypocalcemia was defined as serum calcium level corrected for albumin concentration (cCa) <8.5 mg/dL. Patients with postoperative hypocalcemia were classified as group 1 (n = 100) and those with normal Ca levels as group 2 (n = 122). The PoPTH levels and ΔPTH were compared between the 2 groups. Receiver operating characteristic analysis was performed to determine the cutoff values for PoPTH and ΔPTH.

Results

The mean PoPTH level was significantly lower in group 1 compared with group 2 (18.6 ± 15.3 versus 32.3 ± 15.6 pg/mL, respectively; P < 0.0001). PoPTH values were within the normal range in 54% of the patients with hypocalcemia and 35% of those with symptomatic hypocalcemia. PoPTH <28 pg/mL or ΔPTH >45 were significantly associated with increased risk of post-thyroidectomy hypocalcemia (P = 0.0001). A ΔPTH >70%, PoPTH ≤15.5 pg/mL, and postoperative serum cCa concentrations<8.0 mg/dL significantly predicted symptomatic hypocalcemia (P = 0.009, P = 0.006, and P = 0.0001, respectively). The sensitivities of ΔPTH, PoPTH level, and postoperative serum cCa concentration to predict symptomatic hypocalcemia were 67%, 64%, and 100%, respectively.

Conclusion

Although PTH decline significantly correlates with symptomatic hypocalcemia, a considerable number of patients may experience hypocalcemic symptoms despite normal PoPTH levels. Analysis of serum Ca concentrations at 24 hours postoperatively help to achieve a more precise prediction of patients who bear a high risk for developing hypocalcemic symptoms.
Amplification and Attenuation Across USArray Using Ambient Noise Wavefront Tracking
Authors: Bowden Daniel C. , Tsai Victor C. , Lin Fan‐Chi
Published: November 2017

As seismic traveltime tomography continues to be refined using data from the vast USArray data set, it is advantageous to also exploit the amplitude information carried by seismic waves. We use ambient noise cross correlation to make observations of surface wave amplification and attenuation at shorter periods (8–32 s) than can be observed with only traditional teleseismic earthquake sources. We show that the wavefront tracking approach can be successfully applied to ambient noise correlations, yielding results quite similar to those from earthquake observations at periods of overlap. This consistency indicates that the wavefront tracking approach is viable for use with ambient noise correlations, despite concerns of the inhomogeneous and unknown distribution of noise sources. The resulting amplification and attenuation maps correlate well with known tectonic and crustal structure; at the shortest periods, our amplification and attenuation maps correlate well with surface geology and known sedimentary basins, while our longest period amplitudes are controlled by crustal thickness and begin to probe upper mantle materials. These amplification and attenuation observations are sensitive to crustal materials in different ways than traveltime observations and may be used to better constrain temperature or density variations. We also value them as an independent means of describing the lateral variability of observed Rayleigh wave amplitudes without the need for 3‐D tomographic inversions.
Hyporheic Passive Flux Meters Reveal Inverse Vertical Zonation and High Seasonality of Nitrogen Processing in an Anthropogenically Modified Stream (Holtemme, Germany)
Authors: Kunz Julia Vanessa , Annable Michael D. , Rao Suresh , Rode Michael , Borchardt Dietrich
Published: November 2017

Transformation and retention of nitrogen and other biologically reactive solutes in the hyporheic zones of running water contribute to an essential ecosystem service. However, the synoptic impact of intense agricultural or urban land‐uses, elevated nutrient loading, flow alterations, riparian clear‐cutting, and channelization on the source‐sink behavior of solutes in hyporheic zones remains largely uncharacterized and unquantified. Therefore, we studied nutrient dynamics in a hydromorphologically and chemically modified stream reach using a new monitoring approach allowing the simultaneous measurement of nutrient and water flux through a screened area in the subsurface of rivers (hyporheic passive flux meter, HPFM). With HPFMs we directly assessed time‐integrated lateral hyporheic nitrate fluxes during early spring and midsummer covering different temperature and discharge regimes. Contrary to our expectations, higher stream discharge coincided with substantially lower hyporheic exchange rates. While in streams featuring a natural morphology, bed form induced exchange commonly increases with surface flow, the influence of groundwater level was dominant in this reach. Furthermore, in contrast to less impacted environments, where progressive substrate depletion with depths reduces metabolic rates in the subsurface, we identified not the upper, but the intermediate layer of the hyporheic zone as hot spot of nutrient turnover. Overall, the hyporheic zone at the study site functioned partly as nitrate source, partly as a sink. Neither of the commonly used determinants redox state and residence time could explain this source or sink function. Our results give clear evidence to carefully transfer the knowledge of hyporheic zone processes from “natural” systems to anthropologically modified streams.
A Practical, Robust Methodology for Acquiring New Observation Data Using Computationally Expensive Groundwater Models
Authors: Siade Adam J. , Hall Joel , Karelse Robert N.
Published: November 2017

Regional groundwater flow models play an important role in decision making regarding water resources; however, the uncertainty embedded in model parameters and model assumptions can significantly hinder the reliability of model predictions. One way to reduce this uncertainty is to collect new observation data from the field. However, determining where and when to obtain such data is not straightforward. There exist a number of data‐worth and experimental design strategies developed for this purpose. However, these studies often ignore issues related to real‐world groundwater models such as computational expense, existing observation data, high‐parameter dimension, etc. In this study, we propose a methodology, based on existing methods and software, to efficiently conduct such analyses for large‐scale, complex regional groundwater flow systems for which there is a wealth of available observation data. The method utilizes the well‐established d‐optimality criterion, and the minimax criterion for robust sampling strategies. The so‐called Null‐Space Monte Carlo method is used to reduce the computational burden associated with uncertainty quantification. And, a heuristic methodology, based on the concept of the greedy algorithm, is proposed for developing robust designs with subsets of the posterior parameter samples. The proposed methodology is tested on a synthetic regional groundwater model, and subsequently applied to an existing, complex, regional groundwater system in the Perth region of Western Australia. The results indicate that robust designs can be obtained efficiently, within reasonable computational resources, for making regional decisions regarding groundwater level sampling.
Water Saturation Relations and Their Diffusion‐Limited Equilibration in Gas Shale: Implications for Gas Flow in Unconventional Reservoirs
Authors: Tokunaga Tetsu K. , Shen Weijun , Wan Jiamin , Kim Yongman , Cihan Abdullah , Zhang Yingqi , Finsterle Stefan
Published: November 2017

Large volumes of water are used for hydraulic fracturing of low permeability shale reservoirs to stimulate gas production, with most of the water remaining unrecovered and distributed in a poorly understood manner within stimulated regions. Because water partitioning into shale pores controls gas release, we measured the water saturation dependence on relative humidity (rh) and capillary pressure (Pc) for imbibition (adsorption) as well as drainage (desorption) on samples of Woodford Shale. Experiments and modeling of water vapor adsorption into shale laminae at rh = 0.31 demonstrated that long times are needed to characterize equilibrium in larger (5 mm thick) pieces of shales, and yielded effective diffusion coefficients from 9 × 10−9 to 3 × 10−8 m2 s−1, similar in magnitude to the literature values for typical low porosity and low permeability rocks. Most of the experiments, conducted at 50°C on crushed shale grains in order to facilitate rapid equilibration, showed significant saturation hysteresis, and that very large Pc (∼1 MPa) are required to drain the shales. These results quantify the severity of the water blocking problem, and suggest that gas production from unconventional reservoirs is largely associated with stimulated regions that have had little or no exposure to injected water. Gravity drainage of water from fractures residing above horizontal wells reconciles gas production in the presence of largely unrecovered injected water, and is discussed in the broader context of unsaturated flow in fractures.
Direct Fabrication of Flexible Ni Microgrid Transparent Conducting Electrodes via Electroplated Metal Transfer
Authors: Park Jeonghwan , Lee Kangmin , Um Han‐Don , Kim Ka‐Hyun , Seo Kwanyong
Published: November 2017

A cost‐effective process is reported for fabricating flexible transparent conducting electrodes (TCEs) through the use of a reusable silicon master mold with a microgrid patterned Ag/Cr–metal double layer. Flexible TCEs can be simply produced via metal electroplating on the master mold followed by metal transfer onto a flexible polymer substrate. Nickel (Ni), an inexpensive metal, is used as the TCE material in this study, allowing low‐cost TCE fabrication. The fabricated flexible Ni TCEs exhibit excellent optical and electrical properties (sheet resistance of 6.1 Ω sq−1 with 96% transmittance) along with outstanding mechanical flexibility with no significant change in sheet resistance after 1000 bending cycles at a bending radius of 4 mm. A touch screen panel is also successfully demonstrated using an Ni microgrid TCE to confirm the practical applicability of these TCEs. The results indicate that the proposed flexible Ni microgrid TCEs have potential for rapid commercialization because of their high optoelectronic performance, low cost, and facile fabrication process.
A Hazardous Materials Educational Curriculum Improves Pediatric Emergency Department Staff Skills
Authors: Hewett Elizabeth K. , Nagler Joshua , Monuteaux Michael C. , Morin Michele , Devine Mary , Carestia Michelle , Chung Sarita
Published: November 2017

Objective

Emergency department (ED) providers require competency in responding to hazardous materials (HAZMAT) events. The optimal strategies to teach HAZMAT response principles to ED providers and to ensure skill retention are not known. Our aim was to design, implement, and evaluate a multifaceted, interprofessional educational curriculum for pediatric ED staff to improve their skills, knowledge, and confidence in responding to a HAZMAT event.

Methods

In this longitudinal cohort study, we created and assessed a 3‐hour educational curriculum comprised of didactics, skills stations, a tabletop exercise, and a simulated multivictim disaster. Learning objectives included critical aspects of pediatric HAZMAT incident response with an emphasis on donning personal protective equipment (PPE). The primary outcome was the number of HAZMAT PPE donning steps correctly completed within 10 minutes at pre‐ and postcurriculum assessments measured using a 32‐item checklist. Secondary outcomes included skill retention at 3 months, change in knowledge assessed using multiple‐choice questions, and change in participant confidence.

Results

Eighty‐one of 84 participants (96%) completed the entire curriculum. Compared to the precurriculum assessment, participants completed more donning steps correctly after the intervention (mean increase = 58%, 95% confidence interval [CI] = 48%–70%). Relative to the baseline, more steps were also correctly completed at 3 months (mean increase = 49%, 95% CI = 38%–61%). Performance on multiple‐choice knowledge questions and confidence in skills also significantly increased from the pre‐ to postcurriculum assessments.

Conclusions

A newly developed HAZMAT educational curriculum improved skills‐based performance, knowledge, and confidence in PPE and decontamination skills. Brief, multifaceted educational interventions for ED staff can effectively develop sustainable skills needed for uncommon emergency events.
Phase 1 study of quizartinib in combination with induction and consolidation chemotherapy in patients with newly diagnosed acute myeloid leukemia
Authors: Altman Jessica K. , Foran James M. , Pratz Keith W. , Trone Denise , Cortes Jorge E. , Tallman Martin S.
Published: November 2017

Novel therapies have potential to improve outcomes in patients with acute myeloid leukemia (AML) harboring FLT3‐ITD mutations that have high risk of relapse and poor survival following standard of care (SOC) cytarabine/anthracycline‐based induction/consolidation chemotherapy. Quizartinib is a selective and highly potent FLT3 inhibitor that has shown strong single‐agent activity in relapsed or refractory (R/R) AML. This phase 1, open‐label, sequential group dose‐escalation trial (NCT 01390337) is the first evaluating safety and tolerability of quizartinib in combination with SOC chemotherapy in newly diagnosed AML (ndAML). Nineteen patients unselected for FLT3 mutational status received one of three quizartinib dihydrochloride dose levels (DL): 60 mg/d for 7 days (DL1; n = 6), 60 mg/d for 14 days (DL2; n = 7), and 40 mg/d for 14 days (DL‐1; n = 6); administered orally starting on day 4 of chemotherapy. Median age was 43.8 years. Ten patients completed induction and consolidation. Three patients experienced dose‐limiting toxicities (DLTs): 2 at DL2 (1 pericardial effusion; 1 febrile neutropenia, decreased platelet count, and QT prolongation); 1 at DL‐1 (pericarditis). Maximum tolerated dose (MTD) was identified as DL‐1. Most common grade 3/4 adverse events were febrile neutropenia (47%), neutropenia (42%), thrombocytopenia (32%), and anemia (26%). There were no apparent additional toxicities with addition of quizartinib to chemotherapy although grade ≤1 QT prolongation was observed at MTD. Sixteen patients (84%) achieved a response; 14 (74%) composite complete response; 2 (11%) morphologic leukemia‐free state. The phase 3 QuANTUM‐First trial (NCT02668653) is further evaluating the effect of quizartinib plus SOC chemotherapy in ndAML FLT3‐ITD mutated patients.
The influence of phylogeny, social style, and sociodemographic factors on macaque social network structure
Authors: Balasubramaniam Krishna N. , Beisner Brianne A. , Berman Carol M. , De Marco Arianna , Duboscq Julie , Koirala Sabina , Majolo Bonaventura , MacIntosh Andrew J. , McFarland Richard , Molesti Sandra , Ogawa Hideshi , Petit Odile , Schino Gabriele , Sosa Sebastian , Sueur Cédric , Thierry Bernard , de Waal Frans B. M. , McCowan Brenda
Published: November 2017

Among nonhuman primates, the evolutionary underpinnings of variation in social structure remain debated, with both ancestral relationships and adaptation to current conditions hypothesized to play determining roles. Here we assess whether interspecific variation in higher‐order aspects of female macaque (genus:Macaca) dominance and grooming social structure show phylogenetic signals, that is, greater similarity among more closely‐related species. We use a social network approach to describe higher‐order characteristics of social structure, based on both direct interactions and secondary pathways that connect group members. We also ask whether network traits covary with each other, with species‐typical social style grades, and/or with sociodemographic characteristics, specifically group size, sex‐ratio, and current living condition (captive vs. free‐living). We assembled 34–38 datasets of female‐female dyadic aggression and allogrooming among captive and free‐living macaques representing 10 species. We calculated dominance (transitivity, certainty), and grooming (centrality coefficient, Newman's modularity, clustering coefficient) network traits as aspects of social structure. Computations of K statistics and randomization tests on multiple phylogenies revealed moderate‐strong phylogenetic signals in dominance traits, but moderate‐weak signals in grooming traits. GLMMs showed that grooming traits did not covary with dominance traits and/or social style grade. Rather, modularity and clustering coefficient, but not centrality coefficient, were strongly predicted by group size and current living condition. Specifically, larger groups showed more modular networks with sparsely‐connected clusters than smaller groups. Further, this effect was independent of variation in living condition, and/or sampling effort. In summary, our results reveal that female dominance networks were more phylogenetically conserved across macaque species than grooming networks, which were more labile to sociodemographic factors. Such findings narrow down the processes that influence interspecific variation in two core aspects of macaque social structure. Future directions should include using phylogeographic approaches, and addressing challenges in examining the effects of socioecological factors on primate social structure.
Ancestry and dental development: A geographic and genetic perspective
Authors: Dhamo Brunilda , Kragt Lea , Grgic Olja , Vucic Strahinja , Medina‐Gomez Carolina , Rivadeneira Fernando , Jaddoe Vincent W.V. , Wolvius Eppo B. , Ongkosuwito Edwin M.
Published: November 2017

Objective

In this study, we investigated the influence of ancestry on dental development in the Generation R Study.

Methods

Information on geographic ancestry was available in 3,600 children (1,810 boys and 1,790 girls, mean age 9.81 ± 0.35 years) and information about genetic ancestry was available in 2,786 children (1,387 boys and 1,399 girls, mean age 9.82 ± 0.34 years). Dental development was assessed in all children using the Demirjian method. The associations of geographic ancestry (Cape Verdean, Moroccan, Turkish, Dutch Antillean, Surinamese Creole and Surinamese Hindustani vs Dutch as the reference group) and genetic content of ancestry (European, African or Asian) with dental development was analyzed using linear regression models.

Results

In a geographic perspective of ancestry, Moroccan (β = 0.18; 95% CI: 0.07, 0.28), Turkish (β = 0.22; 95% CI: 0.12, 0.32), Dutch Antillean (β = 0.27; 95% CI: 0.12, 0.41), and Surinamese Creole (β = 0.16; 95% CI: 0.03, 0.30) preceded Dutch children in dental development. Moreover, in a genetic perspective of ancestry, a higher proportion of European ancestry was associated with decelerated dental development (β = −0.32; 95% CI: –.44, –.20). In contrast, a higher proportion of African ancestry (β = 0.29; 95% CI: 0.16, 0.43) and a higher proportion of Asian ancestry (β = 0.28; 95% CI: 0.09, 0.48) were associated with accelerated dental development. When investigating only European children, these effect estimates increased to twice as large in absolute value.

Conclusion

Based on a geographic and genetic perspective, differences in dental development exist in a population of heterogeneous ancestry and should be considered when describing the physiological growth in children.
Hochselektive Mangan(I)/Lewis‐Säure‐cokatalysierte direkte C‐H‐Propargylierung unter Verwendung von Bromallenen
Authors: Zhu Can , Schwarz Jonas Luca , Cembellín Sara , Greßies Steffen , Glorius Frank
Published: November 2017

Eine Mangan(I)/Lewis‐Säure‐cokatalysierte direkte hochselektive C‐H‐Propargylierung wurde entwickelt. BPh3 erhöht bei dieser Propargylierung nicht nur die Reaktivität, sondern auch die Selektivität. Sekundäre, tertiäre und sogar quartäre Kohlenstoffzentren konnten in der propargylischen Position direkt aufgebaut werden. Sowohl interne als auch terminale Alkine können leicht gebildet werden. Die Chiralität konnte erfolgreich von einem axial‐chiralen Allen zu einem Chiralitätszentrum transferiert werden. Die Reaktivität des Mangan‐Katalysators in dieser Umsetzung ist im Vergleich zu anderen Übergangsmetallkatalysatoren einzigartig.
Graphene oxide/poly(ethylene glycol)/chitosan gel with slow‐release lubrication applied on textured surface
Authors: Ren Shanshan , Lu Hailin , Guo Junde , Li Yue , Li Xing , Li Jianhui , Dong Guangneng
Published: November 2017

Graphene oxide/poly(ethylene glycol) (GO/PEG) composites that have biocompatibility and biodegradability properties have been prepared to improve the lubrication of artificial joints, but they would be rapidly degraded and absorbed by the human body if injected. To prolong the lubrication effect, GO/PEG lubricants were mixed into a chitosan (CS) sol, and then the GO/PEG/CS sol was added to the dimpled texture of a Co‐Cr‐Mo alloy and transformed into a gel to slowly release GO/PEG lubricants. The results of friction experiments showed that the average friction coefficient of the slow‐release solution is below 0.025, especially when under pressure, and the gel in the texture also has a good lubrication effect. Meanwhile, the FTIR and UV–vis of the slow‐release solution indicated that it is likely to contain GO, PEG, and CS, which are associated with each other via hydrogen bonds and may form a particular structure, leading to good slow‐release lubrication. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci.2018,135, 45818.
Comb‐shaped copolymer as filtrate loss reducer for water‐based drilling fluid
Authors: Liu Lu , Pu Xiaolin , Rong Kesheng , Yang Yandong
Published: November 2017

A new comb‐shaped copolymer was synthesized by free radical copolymerization of 2‐acrylamide‐2‐methyl propane sulfonic acid, acrylamide, N‐vinyl‐2‐pyrrolidone, and allyl polyoxyethylene ether (APEG) monomers. The copolymer was evaluated as a filtrate loss reducer in water‐based drilling fluid at 180 °C environment, and found to work well without causing high viscosity effect. Composition of the copolymer was determined by Fourier transform infrared spectroscopy (FTIR), proton nuclear magnetic resonance spectroscopy, and gel permeation chromatography. FTIR, X‐ray diffraction,, and environmental scanning electron microscopy characterizations were used to probe the filtrate loss mechanism of the comb‐shaped copolymer. Thermogravimetry and differential scanning calorimetry results showed that thermal degradation of the copolymer is not obvious before 293.6 °C. The copolymer is found to be superior to its commercially available counterparts for controlling filtrate loss volume and maintaining a steady viscosity after 180 °C aging. Higher content of APEG in the copolymer helps maintain rheological properties of the drilling fluid after aging and reduces filtrate loss volume. The morphology of the copolymer in aqueous solution displays a comb‐shaped 3D structure and shows clear adsorption onto clay particles. The working mechanism for copolymer is that anchoring groups bind the copolymer onto clay particles through different binding mechanisms, while colloidal suspension stability is achieved by steric hindrance and electrostatic repulsion, as well as through PEG segment intercalation into clay lamellae. The copolymer is able to cover and seal the micro‐holes in the mud cake even at high temperature to reduce permeability. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45989.
Differentiation potential of human adipose stem cells bioprinted with hyaluronic acid/gelatin‐based bioink through microextrusion and visible light‐initiated crosslinking
Authors: Sakai Shinji , Ohi Hiromi , Hotta Tomoki , Kamei Hidenori , Taya Masahito
Published: November 2017

Bioprinting has a great potential to fabricate three‐dimensional (3D) functional tissues and organs. In particular, the technique enables fabrication of 3D constructs containing stem cells while maintaining cell proliferation and differentiation abilities, which is believed to be promising in the fields of tissue engineering and regenerative medicine. We aimed to demonstrate the utility of the bioprinting technique to create hydrogel constructs consisting of hyaluronic acid (HA) and gelatin derivatives through irradiation by visible light to fabricate 3D constructs containing human adipose stem cells (hADSCs). The hydrogel was obtained from a solution of HA and gelatin derivatives possessing phenolic hydroxyl moieties in the presence of ruthenium(II) tris‐bipyridyl dication and sodium ammonium persulfate. hADSCs enclosed in the bioprinted hydrogel construct elongated and proliferated in the hydrogel. In addition, their differentiation potential was confirmed by examining the expression of pluripotency marker genes and cell surface marker proteins, and differentiation to adipocytes in adipogenic differentiation medium. Our results demonstrate the great potential of the bioprinting method and the resultant hADSC‐laden HA/gelatin constructs for applications in tissue engineering and regenerative medicine.
Identifying Worldviews on Corporate Sustainability: A Content Analysis of Corporate Sustainability Reports
Authors: Landrum Nancy E. , Ohsowski Brian
Published: November 2017

Companies commonly issue sustainability or corporate social responsibility (CSR) reports. This study seeks to understand worldviews of corporate sustainability, or the corporate message conveyed regarding what sustainability or CSR is and how to enact it. Content analysis of corporate sustainability reports is used to position each company report within stages of corporate sustainability. Results reveal that there are multiple coexisting worldviews of corporate sustainability, but the most dominant worldview is focused on the business case for sustainability, a position anchored in the weak sustainability paradigm. We contend that the business case and weak sustainability advanced in corporate sustainability reports and by the Global Reporting Initiative are poor representations of sustainability. Ecological embeddedness, or a locally responsive strategy that is sensitive to local ecosystems, may hold the key to improved ecological sensemaking, which in turn could lead to more mature levels of corporate sustainability worldviews that support strong sustainability and are rooted in environmental science. This must be supported by government regulation. Copyright © 2017 John Wiley & Sons, Ltd and ERP Environment
Melanogenesis‐Inhibitory and Cytotoxic Activities of Chemical Constituents from the Leaves of Sauropus androgynus L. Merr. (Euphorbiaceae)
Authors: Zhang Jie , Zhu Wan‐Fang , Zhu Wei‐Yuan , Yang Pan Pan , Xu Jian , Manosroi Jiradej , Kikuchi Takashi , Abe Masahiko , Akihisa Toshihiro , Feng Feng
Published: November 2017

A new steroid, 20‐hydroxyisofucosterol (stigmasta‐5,24(28)‐diene‐3β,20β‐diol) (7), along with six known compounds 1 – 6 were isolated from the MeOH extract of the leaves of Sauropus androgynus L. Merr. (Euphorbiaceae). The structure of new steroid was determined by HR‐APCI‐MS and various NMR techniques in combination with literature data. Subsequently, their anti‐inflammatory, cytotoxic activities against five human cell lines, as well as inhibitory activities against the α‐MSH induced melanogenesis on the B16 cell line were evaluated. As the results, steroid compounds, 6 and 7 exhibited moderate cytotoxic to HL60, AZ521, SKBR3, and A549 tumor cell lines (IC50 26.9 – 45.1 μm) with high tumor selectivity for A549 relative to WI38 cell lines (SI 2.6 and 3.0, resp.). And, flavonoid compounds, 4 and 5 exhibited superior inhibitory activities against melanogenesis (67.0 – 94.7% melanin content), even with no or low toxicity to the cells (90.1 – 99.6% cell viability) at the concentrations from 10 to 100 μm. Furthermore, Western blot analysis suggested that compound 5 could inhibit melanogenesis by suppressing the protein expressions of MITF, TRP‐1, TRP‐2, and tyrosinase.
Hydroisomerization of Long‐Chain n‐Alkanes over Bifunctional Zeolites with 10‐Membered‐ and 12‐Membered‐Ring Pores
Authors: Zschiesche Christopher , Himsl Dieter , Rakoczy Rainer , Reitzmann Andreas , Freiding Jens , Wilde Nicole , Gläser Roger
Published: November 2017

The hydroisomerization of a C10–C13 n‐alkane mixture was investigated over six bifunctional platinum‐containing zeolite catalysts with 10‐ and 12‐membered‐ring pore systems. The catalysts with 12‐membered‐ring zeolites are more active than those with 10‐membered‐ring zeolites. In contrast, higher yields of the desired monobranched isomers are obtained over the 10‐membered‐ring zeolites due to shape‐selectivity effects. For the 10‐membered‐ring zeolites, higher reaction temperatures are required for achieving the maximum isomer yields, which leads to more cracking products compared to the 12‐membered‐ring zeolites.
Structure–Property Relationships in CuII‐Binding Tetramolecular G‐Quadruplex DNA
Authors: Engelhard David M. , Stratmann Lukas M. , Clever Guido H.
Published: November 2017

A series of artificial metal–base tetrads composed of a CuII cation coordinating to four pyridines, covalently attached to the ends of tetramolecular G‐quadruplex DNA strands [LA–Dd(G4)]4 (LA–D=ligand derivatives), was systematically studied. Structurally, the square‐planar [Cu(pyridine)4] complex behaves analogously to the canonical guanine quartet. Copper coordination to all studied ligand derivatives was found to increase G‐quadruplex thermodynamic stability, tolerating a great variety of ligand linker lengths (1–5 atoms) and thus demonstrating the robustness of the chosen ligand design. Only at long linker lengths, the stabilizing effect of copper binding is compensated by the loss of conformational freedom. A previously reported ligand LE with chiral backbone enables incorporation at any oligonucleotide position. We show that ligand chirality distinctly steers CuII‐induced G‐quadruplex stabilization. 5′‐End formation of two metal–base tetrads by tetramolecular G‐quadruplex [LE2d(G)4]4 shows that stabilization in the presence of CuII is not additive. All results are based on UV/Vis thermal denaturation, thermal difference, circular dichroism experiments and molecular dynamics simulations.
Transient Simulation of Dopant Segregation at Facets During Growth of Nd:YAG Crystal
Authors: Hu Kaiwei
Published: November 2017

Numerical simulation of faceting and dopant segregation for vertical Bridgman growth of Nd:YAG is presented. The numerical scheme for the interface tracking considers the coupling between kinetic model and thermal transport. Dopant distributes inhomogeneously at the radial direction of the crystal/melt interface and piles up in front of the interface near the crucible. The dopant concentration of faceted portions of the crystal/melt interface is higher than that of unfaceted surface. Effect of natural convection on dopant segregation at facets is studied. The dopant boundary layer thickness decreases with the enhancement of the natural convection. The scaling analysis of the dopant boundary layer thickness for facet surface is obtained.
A systemwide review of technical standards
Authors: Ferro‐Lusk Marie
Published: November 2017

Technical standards are the criteria used by health science programs to assess the nonacademic qualifications of applicants and students with disabilities. An example would be the ability to conduct a complete physical examination of the patient. The concept of technical standards comes from the regulations enacting Section 504 of the Rehabilitation Act of 1973, which define a qualified individual as one “who meets the academic and technical standards requisite to admission or participation in the [school's] education program or activity.”
Animal models of fibrodysplasia ossificans progressiva
Authors: LaBonty Melissa , Yelick Pamela C.
Published: November 2017

Fibrodysplasia Ossificans Progressiva is a rare human disease of heterotopic ossification. FOP patients experience progressive development of ectopic bone within fibrous tissues that contributes to a gradual loss of mobility and can lead to early mortality. Due to lack of understanding of the etiology and progression of human FOP, and the fact that surgical interventions often exacerbate FOP disease progression, alternative therapeutic methods are needed, including modeling in animals, to study and improve understanding of human FOP. In this review we provide an overview of the existing animal models of FOP and the key mechanistic findings from each. In addition, we highlight the specific advantages of a new adult zebrafish model, generated by our lab, to study human FOP. Developmental Dynamics 247:279–288, 2018. © 2017 Wiley Periodicals, Inc.