bluuebunny/crossref_metadata_2025 huggingface dataset:
A Study of the Aspects of the Stone Pagodas at Unjusa Temple in Hwasun as Seen in Research Materials from the 1910s
Authors:   The Paek-San Society, Oh Hoseok
Published: January 2025

Unjusa Temple in Hwasun is a cultural heritage site with no precedent in the history of Korean Buddhist art. The temple, known for its numerous stone pagodas, represents the realization of Goryeo Dynasty religious beliefs through stone pagodas. It exemplifies a unique style of Goryeo stone pagodas distinct from the traditional Silla-style pagodas.
The earliest academic research records on the stone pagodas at Unjusa Temple are known as the “Remains of the Dapyeong Pagodas in Jeollanam-do (全羅南道多塔峰の遺蹟),” published by Nomura Yoshihumi in August 1940. However, recently uncovered documents from the National Museum of Korea and the Museum of the Japanese Governor-General of Korea have confirmed that a comprehensive survey of the site was conducted around 1910. These documents establish connections between photographs previously known from the Japanese colonial period, particularly those found in the “Ancient Relics Maps and Photos of the Joseon Dynasty (朝鮮古蹟圖譜)” and the glass plate photos from the Japanese colonial period preserved in the collection of the National Museum of Korea.
This paper investigates and summarizes the survey history of the stone pagodas at Unjusa Temple, beginning with Sekino Tadashi’s “Survey of the 43rd Year of the Meiji Era on the Remains of Korea (明治43年度 朝鮮遺蹟調査略報告)” (1910), conducted by the Finance Department of the Japanese Resident-General's Office in August 1909. It also examines the “Remains of the Dapyeong Pagodas in Jeollanam-do (全羅南道多塔峰の遺蹟),” published with photographs taken by Yatsui Seiitsu, a participant in the survey.
The study includes an analysis of the “Original Photographic Negatives (Jeollanam-do Province)” from the fourth historical records survey conducted by Torii Ryuzo in 1914 under the Korean Governor-General's Education Bureau, as well as the glass photo plates from the Japanese colonial period held by the National Museum of Korea. Additionally, it examines data from the 1917 survey of historic sites and relics in Hwasun-gun and the “Historic Sites and Relics Logbook (古蹟及遺物臺 帳).” Furthermore, changes in the stone pagodas of Unjusa Temple were assessed by comparing the “Jeollanam-do’s Original Registration Document Five (全羅南道 登錄原稿 五),” created in 1917, and the “Datapbong Peak’s Photo Original Plate List (多塔峯寫眞原板⽬錄),” compiled in 1919, with the original plates. This analysis confirms that the existing stone pagodas at Unjusa Temple are cultural heritage artifacts that demonstrate authenticity and integrity, having maintained their original forms since at least the 1910s.
ESTRUTURA EDUCACIONAL DO CAMPO NO CEARÁ E A JUVENTUDE CAMPONESA
Authors: Mendes Alba Regina Andrade , Vidal Marília dos Santos , Lima Maria Aires de , Pereira Karla Raphaella Costa
Published: January 2025

O artigo busca discutir a estrutura educacional do espaço rural cearense apresentando algumas perspectivas para a juventude camponesa. Nesse sentido, primeiro apresenta-se o que se compreende por Educação do Campo, demonstrando seu percurso histórico e as conquistas no campo da política educacional. Em seguida, mais especificamente, apresenta-se a Educação do Campo no Ceará, trazendo algumas nuances importantes para, no próximo tópico, apontar as perspectivas para a juventude camponesa diante do avanço do agronegócio e da estrutura educacional existente no campo cearense. Este estudo se insere em pesquisas financiadas e apresenta resultados ainda parciais, mas que demonstram a necessidade de aprofundamento de pesquisas que tratem da educação dos povos do campo. Concluiu-se, a partir desse estudo, que a presença de empresas que buscam explorar as riquezas naturais do espaço rural cearense tem afetado a vida do camponês, levando para o campo problemas sociais que antes existiam apenas nos grandes centros urbanos. Além disso, a juventude se vê desamparada por não possuir uma formação consistente que possibilite a continuação dos estudos e garanta a permanência no campo com qualidade de vida, o que desemboca no êxodo rural da juventude camponesa.
Pedagogias Decoloniais no Brasil: um estudo sobre o Estado da Arte
Authors: De Oliveira Luiz Fernandes , Miglievich-Ribeiro Adelia Maria
Published: January 2025

O presente texto apresenta um panorama de uma pesquisa realizada sobre o Estado da Arte em Pedagogias Decoloniais no Brasil no campo da educação. Trata-se de um mapeamento da produção acadêmica brasileira materializada em dissertações de mestrado e teses de doutorado de PPGs em Educação disponibilizadas no banco de dissertações e teses da Capes, artigos científicos das revistas de pós-graduações em educação, disponíveis em seu site ou da universidade ou ainda na plataforma Scielo, bem como textos na íntegra nos anais da ANPED (Associação Nacional de Pós-Graduação e Pesquisa em Educação) e do ENDIPE (Encontro Nacional de Didática e Prática de Ensino), no marco temporal de 2001 a 2020. Uma pesquisa qualitativa que faz uso de procedimentos quantitativos para o levantamento bibliográfico e organização, classificação e análise da respectiva produção intelectual.
A Formação Continuada de professores para o Ensino Jurídico: uma análise dos cursos públicos de pós-graduação stricto sensu em direito do estado do Paraná/Brasil
Authors: Tiroli Luiz Gustavo , De Jesus Santos Adriana Regina
Published: January 2025

Consigne-se que o professor é um ator indispensável no processo de ensino e aprendizagem tendo como parâmetro o perfil do profissional que se pretende formar descrito na Proposta Curricular dos Cursos de Pós-Graduação stricto sensu, pois este não se constitui apenas num documento com propostas metodológico-pedagógicas, mas num articulador de ações humanas, uma vez que a sua construção e reconstrução deve ser um espaço para reflexões e estímulo aos docentes para se buscar intensamente a sua concretização. Isso posto, o presente artigo tem como objetivo analisar a concepção dos cursos públicos de pós-graduação stricto sensu em Direito no Estado do Paraná acerca da formação didático-pedagógica do professor no âmbito do ensino jurídico presente na proposta curricular dos cursos. A fim de identificar as estratégias utilizadas pelas Instituições de Ensino Superior no que se refere ao saber e fazer docente, a partir de três categorias: a) objetivos voltados à formação docente; b) estágio docente; e c) disciplinas relativas à formação de professores. Como metodologia, trata-se de uma abordagem qualitativa, onde se adotou a pesquisa bibliográfica e documental tendo como objeto de análise a Proposta Pedagógica dos programas de pós-graduação stricto sensu em Direito. Ao término do estudo constatou-se que os dados coletados evidenciam a necessidade de se repensar a forma como os cursos de mestrado e doutorado tem tratado a formação docente, demandando, inclusive, uma reflexão sobre o processo avaliativo desses cursos junto à Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES).
A DOCÊNCIA COMO PRESSUPOSTO DO DESENVOLVIMENTO SOCIAL E CIENTÍFICO SOB O OLHAR DA HISTORIOGRAFIA DA EDUCAÇÃO: uma análise da universidade.
Authors: Costa Larissa Moreira da , Oliveira Terezinha Oliveira , Oliveira Bruna Castelhano de , BUTION PERIN CONCEIÇÃO SOLANGE
Published: January 2025

Este trabalho tem como objetivo tecer uma reflexão histórica acerca do desenvolvimento da universidade medieval, sobretudo, a universidade do século XIII, a fim de examinar o papel do professor nesse período e refletir como ele pode participar do desenvolvimento social e cientifico do educando. Nosso estudo tem como base a história social e o princípio de longa duração. Para isso analisaremos obras de autores que se dedicam ao estudo da história da educação como Verger, com as obras Universidades e escolas medievais do final do século XI ao século XV (1998) e Os professores (1996), estudos que tratam da origem da Universidade na Europa e da importância dos professores nesta instituição. Além desta obra, utilizaremos Alberto de Boni A universidade Medieval Saber e poder (2002) e a A entrada de Aristóteles no Ocidente Medieval (2010), nas quais ressalta-se a importância das traduções de obras clássicas para o desenvolvimento das instituições universitárias. Considerando a relevância do conhecimento que a Universidade trouxe para o século XIII e a ideia de longa duração, torna-se necessário mencionarmos autores como Grabmann (1949) e Oliveira (2005) que examinam como os mestres desta instituição, em especial Tomás de Aquino,  levavam os discentes ao desenvolvimento social e científico.
SISTEMAS AGROFLORESTAIS NO SUDESTE PARAENSE: uma análise dos censos agropecuários de 2006 e 2017
Authors: Almeida Santos Janaira , Araújo Lucas Flávia Cristina
Published: January 2025

A adoção de sistemas agroflorestais adaptados as condições locais têm mostrado benefícios econômicos, sociais e ambientais. O objetivo desse trabalho foi fazer uma análise descritiva da utilização dos sistemas agroflorestais no sudeste paraense a partir dos resultados dos Censos Agropecuários de 2006 e 2017. Os resultados indicam que no censo agropecuário de 2006 o sudeste paraense apresentava maior participação quanto o número de estabelecimentos e área ocupada por SAFs na maioria das suas microrregiões, e muito embora não haja uma descrição detalhada das características e condições dos SAFs pelo censo, essas mudanças nos dados entre 2006 e 2017 provavelmente estão associadas a dificuldade de implementação dos sistemas, ausência de assistência técnica adequada e com frequência periódica, falta de verticalização da produção, baixo acesso a crédito, dificuldades de escoamento e comercialização. A região demonstra potencial para disseminação desse modelo de produção, principalmente em áreas de assentamento, no entanto é necessário o alinhamento de políticas públicas que garantam apoio técnico e acesso a crédito para incentivar a adesão desses sistemas.
EDUCAÇÃO E CULTURA DA PAZ: UMA REFLEXÃO A PARTIR DO PENSAMENTO DE PAULO FREIRE
Authors: Santos Maria Jesus , Oliveira Poliana Guedes de
Published: January 2025

Este artigo tem como objetivo discutir o alcance da práxis educativa relativa à cidadania e à cultura da paz, dando ênfase ao pensamento de Paulo Freire. Na compreensão freiriana é a vida e a humanidade dos sujeitos que pulsam e se colocam em evidência quando se ensina e aprende e, assim sendo, a efetividade da tarefa educativa se dá pelo nível de compromisso com a transformação do mundo, que passa necessariamente por um processo de re-humanização dos oprimidos e dos opressores e só se torna possível pelo enfrentamento direto de situações de injustiça, opressão, violência e desigualdade. Duas questões nos foram significativas: a - Freire confronta e desmantela a compreensão comum de educação, que a toma como prática que converte, dogmatiza, põe na forma, defendendo, em perspectiva contrária, a educação emancipatória, engajada com e na mudança do mundo, onde o educador e os educandos podem pensar, falar e agir, compartilhando um mundo entre si; b- em Freire, a opressão é um artifício de desumanização implicado à ausência de cidadania e, consecutivamente, à negação de uma cultura da paz, e somente a educação pode alterar o curso dessa história.
Overview of The Neutrophil-Lymphocyte Ration (NLR) as a Prognosis Biomarker of Non-Small Cell Lung Cancer (NSCLC)
Authors: Andayani Novita , Arliny Yunita , Fera Syarifah , Handoko Basti
Published: January 2025

Varied biological markers are not always found in health services with limited resources and high costs. A biological marker named the neutrophil-lymphocyte ratio, we know as NLR has been extensively studied in lung cancer patients regarding its effectiveness as a predictor of evaluation. This study assess NLR as a prognosis in a survival and death scale in Non-Small Cell Lung Cancer (NSCLC) patients. This study used a cross-sectional study design. The samples were advanced stage NSCLC patients undergoing chemotherapy from January 1st 2021 to December 31st 2022 which were limited to the first mid semester of 2023 to see the prognosis of survival and its relationship with NLR. To see the sensitivity, specificity and cut-off point the AUC ROC graph was used. Log-rank test was done for the assessment of the survival. Forty-eight (71.6%) patients died and 19 (28.3%) patients survived. Cut off point of NLR was 3.025, AUC 0.506 with a sensitivity of 83.3%, a specificity of 31.6% p=0.939, survival test NLR >3.025 with average survival of 8.23 months, and NLR ≤3.025 with average survival of 12.95 months. P Value was 0.219. This study identified NLR as a weak biomarker in order to assess the survival prognosis of advanced stage NSCLC patients.
A New Green Analytical RP-HPLC Method Development and Validation for Simultaneous Estimation of Bromhexine and Cephalexin
Authors: Karuna Moparthy Kamala , Nadh Ratnakaram Venkata , Chandu Basavaiah , Prasad Gorumutchu Giri
Published: January 2025

A new green isocratic RP-HPLC method was developed and validated for simultaneous quantification of the Bromhexine and Cephalexin content in tablet formulation, by using relatively eco-friendly – methanol as an organic solvent in the mobile phase. Waters C-18 (250 mm x 4.6 mm, 5 μm) column was used. At room temperature and a flow rate of 1ml/min, the optimized mobile phase was a mixture of Methanol: Ammonium acetate buffer 70:30 (v/v) at a pH of 5.1. The UV detector was set at 228 nm for Bromhexine and Cephalexin determination. The linearity range was 0.2-2 µg/ml and 12.5-125 µg/ml for bromhexine and Cephalexin respectively. The retention times were 3.6 min for bromhexine and 6.2 min for Cephalexin. Undertaken the studies of forced degradation in order to realize the stability indicating the nature of the proposed method. As per the current ICH guides (Q2R1), validation of the method was conducted.
Synthesis and Molecular Docking Studies of Thiazolidineones with Peroxiredoxins as Antioxidant Agents
Authors: P. James Jainey , Pramod Bhandarkar Pavitra , T. S Pavan , Fathima C Zakiya , T. J. Sindhu , P. Varghese Treesa
Published: January 2025

Antioxidants either slow or stop the oxidation processes that occur due to the presence of oxygen or reactive oxygen species in the environment. The schiff base was synthesised and cyclised with thioglycolic acid to yield thiazolidineones (B1-B9). Structural characterisation was performed by IR, Mass and 1H NMR spectral studies. The compounds were checked for antioxidant activity by analysing the interactions with peroxiredoxins (1URM), and Among them, the top-scored compounds were B6 and B4, excellently interacting with the targets. According to the physicochemical and ADME properties of Qikprop, synthesised compounds can be considered druglike molecules. Antioxidant activity studies were conducted using the DPPH method, and the docking results were found from the in vitro studies. Based on these results, it is concluded that the synthesised compounds can be utilised as leads as antioxidant agents, which can be further verified by conducting pharmacological studies.
A Comprehensive Meta-Analysis Reveals Hidden Insights into Ocular Disorders Following COVID-19 Infection
Authors: Yersariyeva Zhadyra
Published: January 2025

Aims/Objectives: This study aimed to explore the mechanistic links between COVID-19 and ocular disorders. The study sought to identify specific diseases, assess the effectiveness of treatment approaches, and provide insights into the broader implications for patient care. Methodology: We conducted a systematic search of PubMed and Medline databases, collecting relevant studies until June 2023. A rigorous PRISMA-based selection process ensured high-quality research inclusion. Bias risk assessment followed Cochrane's "Systematic Reviews of Interventions" guidelines. Five studies were selected for meta-analysis using Review Manager with a fixed-effects model, and heterogeneity was assessed. Results/Findings: Our analysis revealed substantial heterogeneity in ocular presentations post-COVID-19 infection (p<0.00001; I^2=97%). Notable findings included vision improvement in patients treated with oral steroids and intravenous methylprednisolone, as well as resolution of uveitis through cycloplegic and topical steroids. Scientific Novelty/Contribution: This study sheds light on a lesser-explored facet of COVID-19, highlighting ocular disorders as potential viral symptoms. It contributes novel treatment insights and underscores the importance of considering ocular health in COVID-19 patient care. Conclusion/Implications: Ocular disorders post-COVID-19 infection warrant attention from clinicians and researchers. Further investigations are essential to refine treatment strategies and improve the overall care of COVID-19 patients. Recognizing the ocular dimension of this viral illness is crucial for a holistic approach to healthcare delivery in the post-pandemic era.
Development and Evaluation of bi-layer Tablet Containing Sustained-Release and Immediate Release Celecoxib
Authors: Gawai Snehal , Dhoble Nilakshi , Mandal Priyanka , Padole Nitin , Dhapake Pankaj
Published: January 2025

The purpose of this study is to prepare a bilayer tablet of Celecoxib using wet granulation technology and to formulate an optimized formulation. Celecoxib is a non-steroidal anti-inflammatory drug that inhibits the prostaglandin-generating enzyme cyclo-oxygenase 2 and reduces the pain and inflammation of Osteoarthritis. Fast release of the drug from the immediate-release layer can give a rapid onset of action which will help to reduce pain and inflammation within a short period while the maintenance dose of Celecoxib will maintain plasma concentration within the therapeutic range for 24 hours. Permeability enhancers such as Chitosan were used, which can increase the permeability as well as bioavailability of the drug. In this study, a bilayer tablet was prepared which contains an immediate release layer and a sustained release layer. HPMC K100 was used to maintain sustained release and Croscarmellose Sodium for immediate release. Sodium Starch Glycolate and Cross Povidone were used as super disintegrants. The bilayer tablets were tested for weight variation, hardness, friability, thickness, drug content, in-vitro dissolution profile, bulk density, tapped density, angle of repose, carr’s index, Hausner's ratio, and calibration curve. The granules showed satisfactory flow properties and compressibility. The best formulation L5 showed a High % drug release 96.04% release, high drug content, high hardness, and friability. Bilayer tablet is enhancing beneficial technology to control the shortcomings of the single-layered tablet. The aim of designing sustained or controlled delivery systems is to decrease the repetition of the dosing or to increase the effectiveness of the drug by localization at the site of action, lowering the dose required, or providing uniform drug delivery. The main objective of sustained release drug delivery is to make sure safety and to improve patient compliance.
Exploration of Self-Management Strategies for Type 2 Diabetes Mellitus among patients in Rural Community Health Centers: A Descriptive Study
Authors: Nopitasari Anggi , Thesa Ghozali Muhammad
Published: January 2025

This study investigates the self-management strategies of Type 2 Diabetes Mellitus (T2DM) patients in rural settings, addressing a significant gap in current diabetes research. Focusing on a rural community in Indonesia, the study aims to understand the unique challenges and practices in managing T2DM where healthcare resources are limited. Using quantitative and qualitative methods, the research surveyed 50 T2DM patients at a private hospital's outpatient facility. The study's findings reveal a predominant trend of moderate self-management among participants, highlighting the crucial role of patient education, family support, and community engagement in effective diabetes care. It emphasizes the need for targeted educational programs and patient-centered healthcare approaches, especially in resource-constrained rural areas. The research underscores the importance of integrating local cultural and socio-economic contexts into diabetes care strategies. Moreover, the study suggests the potential role of digital health tools in bridging healthcare gaps in rural communities. Despite its contributions, the study acknowledges limitations such as potential biases in self-reported data and limited generalizability beyond the rural Indonesian context. Overall, this research provides valuable insights into diabetes self-management in rural settings and suggests directions for future interventions and policy-making to improve the quality of life and health outcomes for patients with T2DM in similar communities.
New spectrophotometric methods for the determination of Loratadine
Authors: Mathrusri Annapurna Mukthinuthalapati , Heshitha Pappala
Published: January 2025

Loratadine is a second-generation antihistamine that is used to treat allergic rhinitis and hives. New spectrophotometric techniques have been proposed for the estimation of Loratadine in pharmaceutical dosage forms. A double-beam SHIMADZU Model UV-1800UV-VIS spectrophotometer was used for the present study. Loratadine has shown linearity over the concentration range 0.5-50 µg/mL in borate buffer (pH 9.0), phosphate buffer (pH 5.8), phosphate buffer (pH 7.8), and distilled water, and the methods were validated as per ICH guidelines. The proposed methods are simple, and economical and can be successfully applied for the assay of Loratadine in pharmaceutical dosage forms.
Preclinical evaluation of pods of Ageratina adenophora for its rudimentary fatal activity
Authors: Majumdar Mrityunjoy , Sekhar Sarkar Nilendu , Das Debapriya , Samanta Arnab , Roy Sourav , Roy Prodip , Dutta Soumyadeb
Published: January 2025

Ending a pregnancy is quite common these days. In developing countries, there are much more cases termed as unsafe abortion. Some standard drugs are already available in the market, most of them are possessing high level of toxicity and expensive. There is always search for a new drug which is safe and cost effective. Ageratina adenophora is a medicinal plant in the Asteraceae family. It mainly contains alkaloids. In this experiment, the study was focused on evaluating the abortifacient effect of Ageratina adenophora. The hydroalcoholic extract of the pods of Ageratina adenophora was formed by the maceration process. The extract has shown a promising effect as an abortion-inducing agent while compared with the standard drugs. The animals treated with the extract of Ageratina adenophorahas decreased the abortion time within 15.01 hrs with 85.22 percent fatality in offspring which is noteworthy. The research outcomes indicate that the hydroalcoholic extract of the pods of the Ageratina adenophora has shown significant abortifacient activity.
Phytochemical composition by GC–MS, Invitro Antioxidant, Insilico chemical active compound of Chromolaena odorata L. weed extract targeting EGFR as Anti Lung Cancer
Authors: Hardianti Besse , Amin Astuti , Lallo Subehan , Hertati Ai
Published: January 2025

Chromolaena odorata L. is an unexploited weed that can be used in various traditional medicine systems. This study aims to identify active compounds that have effects as antioxidants from three parts of C. odorata weed leaves (LOD), stems (SOD), and roots (ROD) in vitro and silico as active ingredient candidates against lung cancer. Antioxidants were carried out using Beta Carotene Bleaching (BCB), Nitric Oxide (NO), and Cupric Ion Reducing Antioxidant Capacity (CUPRAC) methode. Identification of lung anticancer compounds with silicon molecular docking method compares Gefitinib (5GU8) protein binding affects lung cancer cell growth. From the results of identification with GC–MS from ethanol extract of C. odorata, eight metabolites were obtained, most of which were phenolic, and FT–IR profile obtained the presence of C–H, C=C, C–O, N–H, C–N, and O–H groups. In antioxidant testing with BCB, NO and CUPRAC methods showed powerful antioxidant activity in ethanol extract LOD (IC50≤50), in ethanol extract SOD with strong activity (IC50 = 50–100), and ethanol extract ROD obtained moderate activity (IC50 = 100–150). The total phenolic content (TPC) of C. odorata extracts varied significantly (P < 0.05) from 2.319–7.518±0.023–0.04 and total flavonoid content (TFC) 0.434±0.022–0.41. Pearson correlation test and principal component analysis showed the relationship between TPC and TFC of various antioxidant activity assays of C. odorata extracts. In–silico studies of eight compounds were found to fulfill Lipinski's Rule of Five, which means they have good bioavailability. The molecular docking simulation results showed that each compound had a better affinity to EGFR than Gefitinib (5GU8). Visualization showed that the compounds interacted with amino acid residues Met793, Gln791, Leu718, Thr854, Asp855, and Lys745. Toxicity testing showed that the compounds obtained were non-toxic and non-carcinogenic. The results indicate that the compounds obtained can be used as anti-lung cancer candidates through EGFR inhibition.
Principal component analysis (PCA) of bioactive compounds and antioxidant activity of various sample particle sizes of sea urchin shells from coastal area of Lombok Island
Authors: Ocktaviana Saputri Legis , Nurhidayati Nurhidayati , Syafii Harahap Herpan , Faradina Zubaidi Fitriannisa , Windri Rivarti Arina , Permatasari Lina
Published: January 2025

The most common technique in increasing pharmacological activity is by reducing sample particle size. This study aims to investigate the impact of different particle sizes on the bioactive composition and antioxidant activity of sea urchin shells collected from the coastal areas of Lombok Island. Sea urchin shell powders ranging in particle sizes <45 µm, >45 µm, <125 µm, >250 µm, and >2000 µm were extracted using 70% ethanol via the cold maceration method. The composition of bioactive compounds was analyzed using GC-MS, while antioxidant activity was evaluated using the DPPH free radical scavenging assay. Principal Component Analysis (PCA), conducted using Minitab software, was employed to summarize the interrelationships among all variables in the study. The findings reveal that each particle size exhibits a distinct composition of bioactive compounds. The highest concentrations of bioactive compounds and the greatest antioxidant activity were observed in samples with particle sizes >45 µm. PCA identified several bioactive compounds, such as lanolin, palmitic acid, myristic acid, stearic acid, heptadecene-(8)-carboxylic acid, 5,8,11,14-eicosatetraenoic acid, and 9-hexadecanoic acid, contributing significantly to this antioxidant effect. Reducing the particle size was found to alter the composition of bioactive compounds and enhance antioxidant activity. These bioactive compounds show promise for further exploration in the development of new drugs derived from marine sources.
Antidiarrheal Activity of Kejek Tea Infusion (Camellia sinensis L.) in Swiss Webster Male Mice
Authors: Sadino Asman , Renggana Hesti , Qowiyyah Atun , Apriani Riza , Susanti Risa , Silviani Salsa
Published: January 2025

Currently, many medicinal plants claim to have traditional therapeutic value, but their efficacy is not supported by scientific evidence. People in Indonesia, particularly those in rural areas, continue to lack access to official health services. They frequently treat illnesses with natural remedies, particularly diarrhea. Therefore, this study was conducted to evaluate the antidiarrheal activity of kejek tea infusion (C. sinensis L.) in male mice of the Swiss Webster strain. The method used in this study was a protection method against oleum ricini induction, with the following parameters observed: onset and duration of diarrhea, frequency of diarrhea, stool weight, stool consistency, and intestinal transit method to see the mechanism of antidiarrheal action on intestinal peristalsis, based on the effect on the ratio of the intestinal distance taken by a marker in a specific time, in experimental animals. The results indicated that the infusion of Kejek tea with various concentrations, notably 3%, 4%, and 5%, had anti-diarrheal activity by decreasing the weight of the stool, the frequency of diarrhea, the stool consistency score, the duration of diarrhea, the onset of diarrhea, and the ratio of passages traversed by norit in Swiss Webster male mice induced by oleum ricini. The Kejek tea infusion test preparation with a concentration of 5% exhibited the highest antidiarrheal activity. Further studies are needed to support the source of new potential agents as anti-diarrhea derived from natural ingredients.
A Comparative Analysis of Research Remunerations in India and Abroad: Trends, Challenges, and Implications
Authors: Sagar Samrat Mohanty
Published: January 2025

Research scholars are the backbone of India’s scientific and academic ecosystem. Their contributions to knowledge creation and innovation are critical for national progress. However, despite their importance, research scholars in India often face systemic issues related to remuneration, which impacts their motivation and productivity. This study uses a mixed-methods approach, combining both quantitative stipend data analysis and qualitative survey responses from Indian research scholars. This paper examines the trends in research stipends for PhD students and research scholars in Indian research labs, from 2004 to 2023. It analyzes the growth of these stipends over time, compares them with those offered in other countries like USA, UK, Germany, China and Japan, and presents findings from a survey on the challenges faced by Indian research scholars due to inadequate financial support. The paper argues that the relatively low stipends in India pose significant challenges to researchers, hindering their progress and potentially impacting the quality of research output. The study also highlights the disparity in research stipends between India and other nations and discusses its implications for research quality and the scientific workforce.
Could the R2C2 Feedback and Coaching Model Enhance Feedback Literacy Behaviors: A Qualitative Study Exploring Learner-Preceptor Feedback Conversations
Authors: Ramani Subha , Armson Heather , Hanmore Tessa , Lee-Krueger Rachelle , Könings Karen D. , Roze des Ordons Amanda , Zetkulic Marygrace , Sargeant Joan , Lockyer Jocelyn M.
Published: January 2025

Introduction: Feedback literacy (FBL) is a critical skill for learners encompassing four behaviors: appreciating feedback, making judgements, managing affect, and taking action. Little guidance has been available for clinical preceptors to promote FBL. The R2C2 feedback and coaching model that guides teachers through building Relationships, exploring Reactions and Reflections, discussing Content and Coaching to co-develop an action plan for follow-up may support FBL. This study sought to identify whether R2C2 conversations operationalized FBL behaviors and the factors that appeared to influence FBL.
Methods: Based on data from a multi-institutional, qualitative study involving 15 dyads of learners (residents and medical students) and their physician preceptors, a secondary analysis of R2C2-guided feedback conversations and debriefing interviews was undertaken. A framework analysis mapped the data to FBL behaviors and explored factors that impacted behaviors in the context of the research and theories underpinning R2C2 and FBL.
Results: Most elements of FBL behaviors were demonstrated in R2C2 conversations. Appreciating feedback and making judgements were most consistently noted. There was less evidence of managing affect as learners indicated acceptance of feedback. There was variability in the co-creation of action plans. Some created action plans, others had incomplete or no plan for immediate action or follow-up. FBL appeared to be impacted by learner-preceptor relationships, active learner engagement in feedback discussions, and personal characteristics.
Discussion: Our analysis demonstrated that effective use of the R2C2 model could enhance FBL behaviors provided attention was paid to optimizing all phases of R2C2, particularly co-creation of action plans for follow-up.
Stavovi nastavnika matematike prema
korištenju aplikacije Photomath u rješavanju matematičkih problema
Authors: Bešić Alma
Published: January 2025

Ovaj rad se bavi istraživanjem stavova nastavnika matematike prema aplikaciji PhotoMath u kontekstu rješavanja matematičkih problema, te identificira varijacije u tim stavovima prema razini nastave, obrazovnim kvalifikacijama i iskustvu. Ispitanici su bili 332 nastavnika iz četiri kantona Federacije Bosne i Hercegovine tijekom školske godine 2023/2024. Za prikupljanje podataka korišten je anketni upitnik s 27 stavki, preuzet iz rada Hamadneh & Al – Masaeed (2015), te su analizirani i sekundarni podaci iz literature. Analiza podataka obuhvatila je izračun srednjih vrijednosti, standardnih devijacija, t-testova za procjenu razlika između grupa, te jednosmjernu analizu varijance (ANOVA) za ispitivanje statistički značajnih razlika među grupama. Rezultati ukazuju na umjeren pozitivan stav nastavnika prema PhotoMath aplikaciji, s naglaskom na važnost aplikacije za pomoć u rješavanju matematičkih problema, ali i zabrinutost zbog potencijalne zamjene tradicionalne uloge nastavnika. Iako nije bilo statistički značajnih razlika u stavovima prema PhotoMathu u odnosu na razinu obrazovanja u kojoj su zaposleni, uočene su razlike prema obrazovnim kvalifikacijama i radnom iskustvu nastavnika. Zaključak istraživanja naglašava potrebu za daljnjim istraživanjem utjecaja tehnologije na obrazovanje te prilagodbom obrazovnih politika koje podržavaju integraciju digitalnih alata u nastavu matematike.
Analysis of Legal Protection Reconstruction for Debtors in Auction Execution of Mortgage Matters Based on Justice
Authors: Winoto Taufik Pandan , Izhandri Shandi , Wibowo Wahyu Adi , Mashdurohatun Anis , Azam Muhammad
Published: January 2025

The execution of collateral foreclosure often results in both material and immaterial losses for debtors. The process of auctioning collateralized assets frequently leads to disagreements when debtors resist the auction's outcome, creating legal issues for the auction winners. Many disagreements arise when creditors conduct foreclosure auctions through the State Asset Management and Auction Service Office (without going through the courts, as regulated by Law No. 4 of 1996 on Mortgage Rights. This often leads to lawsuits for unlawful acts. The research aims to analyse the legal risks in credit transactions that lack justice-based principles, identify the weaknesses in legal protections for debtors and auction winners, and explore the reconstruction of legal protection regulations for debtors experiencing defaults. This study uses the constructivist paradigm, focusing on the legal rules governing foreclosure, utilizing a social-legal research approach. The research method involves normative legal studies, focusing on legal documents and literature. The findings reveal that current legal regulations, particularly Law No. 4 of 1996 on Mortgage Rights and related banking laws, fail to provide adequate legal protection for debtors in default, who often suffer losses due to the lack of balance between the rights and obligations of creditors and debtors. The study highlights the need for reconstructing legal norms to ensure fairness, emphasizing the imbalance in legal protections for debtors, including issues in the legal structure, substance, and culture. The research concludes that reconstructing justice-based legal protections is essential to create a balance between the rights of debtors and creditors, and this can be achieved through the revision of current legal frameworks to better address issues in cases of default.
Evaluation of the acute toxicity, analgesic, anti-inflammatory and neuroprotective effect of Artemisia herba-alba (Asso) essential oil
Authors: Amara Lallia , Zairi Mohamed , Labadi Khaled , Achemaoui Amine
Published: January 2025

Artemisia herba-alba (Asso.) is an aromatic and medicinal plant with several therapeutic virtues. This study aimed to determine the toxicological profile as well as to evaluate in vivo the analgesic, anti-inflammatory and neuroprotective effect of Artemisia herba-alba essential oil (A. herba-alba EO). The EO was extracted from the aerial part by hydrodistillation using a Clevenger-type apparatus. The acute toxicity was determined according to the OECD guidelines 423. The anti-inflammatory effect was investigated by evaluating the paw edema development induced by carrageenan injection. The analgesic effect was assessed according to the number of writhes induced by the intraperitoneal injection of acetic acid (0.6%). A histological study of the brain was carried out to determine the neuroprotective effect of the EO against damage induced by applying various stress factors.Our findings showed that the EO was weakly toxic with a LD50 of 1000 mg/kg. The results of the anti-inflammatory effect showed that the EO reduced significantly (p<0.05) the paw edema in the rat’s paw at 67.7% and 80.48% (after 5h) at the doses of 50 mg/kg and 100 mg/kg respectively. Moreover, the EO significantly decreased (p<0.0001) the number of cramps in mice with a percentage of inhibition of 25.08 % and 48.86% respectively for the doses of 50 and 100 mg/kg. Brain microphotography showed a protective effect of the EO against stress-induced neuroinflammation. The obtained results confirmed the anti-inflammatory, analgesic and neuroprotective effect of Artemisia herba-alba EO.
Relevância e desafios do Sistema Manchester de Classificação de Risco no atual cenário de urgência e emergência: uma revisão integrativa da literatura
Authors: Donadai Kelly Cristina Encide de Vasconcelos , Medeiros Rodolfo de Oliveira , Zanelato Marcus Vinícius da Silva , Hamada Vanessa Vieira , Santos Rafael Ignácio dos , Maldonado João Victor de Oliveira , Tiradentes Teófilo Augusto Araújo , Peixoto Maria Júlia Daniel , Ribeiro Maricláudia Damaceno , Muzzi Cristiana Candido Amorim , Alves Caroline Diniz , Targa Laura Modenese , Nascimento Jenifer Nicrite , Ribeiro Mariana Damaceno , Mascarin Aline Maria Noli
Published: January 2025

Introdução: Atualmente, o sistema de classificação de risco mais utilizado em âmbito nacional é o Protocolo de Manchester, que consiste em uma estratégia para estabelecer prioridade de atendimento a partir dos critérios clínicos que o paciente apresenta ao procurar os serviços de urgência e emergência para atendimento. Objetivo: analisar e refletir, a partir de evidências literárias, sobre a relevância e desafios do Sistema Manchester de classificação de risco no atual cenário de urgência e emergência. Método: Revisão Integrativa da Literatura, realizada nas bases de dados SciELO, BINACIS, MEdLINE, LILACS e Coleciona SUS. Os critérios de inclusão foram artigos originais, disponíveis na íntegra, nos idiomas português, inglês e espanhol, com período de publicação entre os anos de 2018 a 2024. Foram excluídas dissertações, teses, estudos secundários e editoriais. Resultados e discussão: Foram selecionados 14 artigos para compor a discussão, que se estabeleceu a partir de duas categorias analíticas: Relevância do protocolo de Manchester no cenário de urgência e emergência e desafios enfrentados no manejo do Protocolo de Manchester no cenário de urgência e emergência. Considerações finais: Os aspectos relevantes do Sistema Manchester de Classificação de Risco são a organização do serviço, redução de sequelas e taxa de mortalidade, melhora na qualidade do atendimento e satisfação do paciente. Porém, os desafios da falta de conhecimento dos profissionais e da população sobre o Protocolo, a superlotação e a falta de adaptações sugerem a necessidade de monitoramento periódico, através de espaços de educação permanente e auditorias internas, no intuito de padronizar o manejo do Sistema Manchester e superar os desafios apresentados por esta pesquisa.
Aproveitamento de resíduos sólidos de restaurante estudantil e resíduos de açaí para produção de composto orgânico
Authors: Silva Risete Maria da , Santana Raila da Rosa , Brito Edna Antônia da Silva
Published: January 2025

Objetivou-se analisar e quantificar os diferentes nutrientes e componentes presentes nos compostos orgânicos a partir da compostagem de resíduos sólidos de restaurante estudantil e resíduos de caroços de açaí. O estudo foi realizado no período de agosto à dezembro de 2024 na área experimental agroecológica, situado no Instituto Federal do Pará – Campus Bragança-PA. O material empregado para o processo de compostagem consistiu de resíduos orgânicos gerados no Restaurante Estudantil do Campus Bragança e de caroços de açaí coletados na cidade. Os resíduos do restaurante estudantil eram colhidos manhã, tarde e noite. Os resíduos de açaí foram coletados duas vezes ao mês de agosto a dezembro, totalizando cerca de 5.000 mil quilos e colocados para compostar em quatro leiras na área experimental do Campus. O local para a decomposição dos resíduos tinha as medidas de 4,34 m de comprimento x 1,0 m de largura x 1,2 m de altura com um volume de 3970 litros. O volume final foi de 1.627 litros de compostos orgânicos. A compostagem é uma alternativa potencial para a reciclagem de resíduos sólidos orgânicos gerados nestes ambientes estudados.
A Lei nº 13.415/2017: reformulação do currículo do ensino médio na perspectiva pelo viés docente
Authors: Duarte Paula Regina da Siva , Fernandes Stenio de Brito , Lorena Míssola Arezza Bezerra da Costa , Medeiros Risalva Ferreira Nunes de , Solano Fernanda Hingridy da Silva , Oliveira Filho Antônio Soares de , Fonseca Ivânia Melo da , Gurgel Iury Coutre
Published: January 2025

Várias foram às formas de se pensar e impor os currículos escolares desde quando a Educação passou a ser organizada de forma sistemática até os dias atuais. Recentemente, o Ensino Médio passou por uma reforma em seu currículo com a implantação da Lei Nº 13.415/2017. Objetivamos refletir sobre as perspectivas de docentes acerca do novo currículo do Ensino Médio de acordo com a Lei Nº 13.415/2017. Dessa forma, a pesquisa é de abordagem qualitativa, na qual aplicamos um questionário não-estruturado com três docentes que atuam em turmas do Ensino Médio e que lecionam componentes curriculares divergentes em diferentes instituições da rede pública estadual de Mossoró/RN. Para interpretação dos questionários, utilizamos a análise de conteúdo fundamentada nos pressupostos de Bardin (2016). Como resultados a pesquisa apontou que os docentes do Ensino Médio não participaram de forma ativa do processo de construção do currículo do novo Ensino Médio, não receberam formação suficiente para sua implementação, além disso, os participantes da pesquisa salientam também a retirada de conteúdos fundamentais de suas disciplinas, a redução da carga horária e a falta de material para trabalhar. Portanto, a pesquisa revela dados preocupantes quanto à construção unilateral e neoliberal do atual currículo do Ensino Médio.
Quais medidas hemostáticas reduzem o risco de hemorragia trans e pós cirurgia bucal em hemofílicos? Uma revisão de literatura integrativa
Authors: Rodrigues Laíse Nunes , Oliveira Viviane Cardoso Lima de , Ribeiro Marilene de Fátima Reis , Bassi Daniela Dibai , Costa Cyrene Piazera Silva
Published: January 2025

O objetivo desta revisão de literatura integrativa foi identificar as medidas em pessoas com hemofilia que reduzem o risco de hemorragia trans e pós cirurgia bucal. Foi realizada uma busca nas bases de dados BVS (Biblioteca Virtual em Saúde), BIREME (Biblioteca Regional de Medicina), LILACS (Literatura Latino-Americano e do Caribe em Ciências da Saúde), IBECS (Índice Bibliográfico Espanhol de Ciências de Saúde), MEDLINE (Medical Literature Analyses and Retrieval System Online), BBO (Biblioteca Brasileira de Odontologia), PubMed, SciELO (Scientific Electronic Library Online), BDTD (Biblioteca Digital Brasileira de Teses e Dissertações) e EBSCOHost com a estratégia de busca, "Hemophilia" AND "Oral Surgery" AND "Hemostatics" AND "Hemorrhage". Foram incluídos estudos observacionais em humanos publicados desde 1996 em português, inglês ou espanhol foram eleitos para esta revisão. A extração dos dados dos artigos foi realizada com ajuda de um roteiro. As variáveis dos dados foram autores e ano, título, desenho do estudo, contexto, participantes, variáveis, fontes de dados e mensuração, tamanho do estudo, métodos estatísticos e resultados principais. Foram encontradas 15 referências. Destas, três foram selecionadas. Conclui-se que a combinação de tratamento sistêmico e medidas hemostáticas locais reduzem o risco de hemorragia trans e pós exodontia.
Applications and Development of Fuel Cells in the Field of New Energy Vehicles
Authors: Wu Zihao
Published: January 2025

People favor new energy vehicles due to their advantages of low cost and zero emission. However, the current battery technology cannot fully meet the range and charging speed requirements, which restricts the further development of new energy vehicles. Fuel cells are characterized by high energy density and environmental friendliness, showing great advantages in solving energy and environmental problems. It may be able to replace the current lithium battery as the battery choice for the next generation of new energy vehicles. There have been many researchers carrying out related studies and launching mass production models, but there are still many problems to be solved. This paper begins with an introduction of the research background, power generation principle, and classification of fuel cells, and discusses the current problems encountered in lithium battery technology as well as the latest research progress, challenges, and future development direction of fuel cells in the automotive field. Through this article, researchers can gain an understanding of the principle of various types of fuel cells, have a cognizance of the current in-vehicle applications of lithium batteries and fuel cells, and have a certain understanding of the future development of in-vehicle fuel cells.
EXAMINING THE ROLE OF REFLECTIVE PRACTICES IN ENHANCING CLINICAL REASONING SKILLS AMONG NURSING STUDENTS IN THE COLLEGE OF NURSING NMU MULTAN
Authors: MANZOOR R , MAJEED S , KHALID R , ANWAR M
Published: January 2025

Clinical reasoning is a vital skill for nursing students, enabling them to provide high-quality patient care. Reflective practices, such as journaling and structured feedback, have been recognized as effective tools for enhancing clinical reasoning skills. However, limited research exists on the integration of reflective practices in nursing education in Pakistan. Objective: To examine the role of reflective practices in enhancing clinical reasoning skills among nursing students at the College of Nursing, Nishtar Medical University, Multan. Methods: A descriptive cross-sectional study was conducted with 130 BSN nursing students. Data were collected using a validated questionnaire assessing the use of reflective practices, clinical reasoning skills, and associated challenges and facilitators. Descriptive statistics were employed to analyze the data using IBM SPSS version 26. Results: The majority of students (90%) reported that reflective practices improved their clinical reasoning skills. Key challenges included lack of time (65.4%) and inadequate guidance from educators (34.6%). Facilitators included educator support (69.2%) and structured reflective tools (65.4%). Conclusion: Reflective practices significantly enhance clinical reasoning skills among nursing students in Pakistan. Addressing barriers such as workload and training gaps can optimize the use of reflective practices, leading to improved nursing education and patient outcomes.