bluuebunny/crossref_metadata_2025 huggingface dataset:
Health-promoting lifestyle behaviors and their associated factors among pregnant women in Debre Markos, northwest Ethiopia: a cross-sectional study
Authors: Mihiret Getachew Tilaye , Meselu Belsity Temesgen , Wondmu Kumlachew Solomon , Getaneh Temesgen , Moges Nurilign Abebe
Published: January 2025

Introduction

Promoting healthy lifestyle behaviors during pregnancy is a crucial health promotion strategy that could reduce pregnancy-related complications that may harm women and their fetuses. However, very few studies have assessed the prevalence of health-promoting lifestyle behaviors among pregnant women in Ethiopia. This study aimed to evaluate the extent and associated factors of health-promoting lifestyle behaviors among pregnant women in public health institutions in Debre Markos, northwest Ethiopia.

Methods

An institutional-based cross-sectional study was conducted among 275 pregnant women who were recruited using a systematic random sampling technique from 19 April to 19 May 2021. A face-to-face interview-administered questionnaire was used to collect the data. The data were analyzed using SPSS version 25. Multivariable binary logistic regression was used to identify the factors associated with the outcome variable. adjusted odds ratio (AOR), with a 95% confidence interval (CI) were used to measure the strength of the associations at a p-value <0.05.

Results

The average mean score for health-promoting lifestyle behaviors was 2.68 (±0.38). Factors such as rural residency (AOR = 0.29; 95% CI = 0.10–0.82), family size (≥5) (AOR = 0.25; 95% CI = 0.08–0.79), being the decision-maker for economic expenses (AOR = 0.34; 95% CI = 0.14–0.84), and average monthly income (AOR = 0.15; 95% CI = 0.04–0.59) were found to be significantly associated with health-promoting lifestyle behaviors during pregnancy.

Conclusion

Approximately two-thirds of participants demonstrated better (healthier) health-promoting lifestyle behaviors during their pregnancy. To reduce unhealthy lifestyle-related maternal morbidity and mortality in Ethiopia, it is important to encourage health-promoting activities through health education and antenatal care follow-up with an emphasis on women who reside in rural areas, and who have a high family size, low income level, and have husbands who are the primary decision-makers for their economic expenses.
Prescribing practices of corticosteroids in outpatient dermatology department of Injibara General Hospital, north-West Ethiopia, 2024
Authors: Tegegnie Alemu Bezabih , Alene Tamiru , Tamir Workineh , Sineshaw Meaza Molla
Published: January 2025

Background

Corticosteroids are among the most frequently prescribed drugs in the world because they are extremely effective for the relief of symptoms of many inflammatory and immune disorders and other conditions. Corticosteroids have been a mainstay of pharmacotherapy in dermatological practice.

Objective

This study aimed to assess prescribing practices of corticosteroids in outpatient dermatology department of Injibara General Hospital, North-West Ethiopia, 2024.

Method

A facility-based retrospective cross-sectional study was conducted from September 1 to September 10, 2024, with 422 patient prescriptions issued at the dermatology outpatient department of Injibara General Hospital containing at least one corticosteroid medicine. All patient prescriptions dispensed from the dermatology outpatient department from April to August 2024 containing at least one corticosteroid medicine were included. A structured data collection tool was used to collect data, and Statistical Package for Social Science version 27.1 was used for data analysis. The study population was characterized through descriptive analysis.

Results

Female patients accounted 54.2% of the cases recorded, and the most common age group was between 21 and 30 years (26.5%). Atopic dermatitis (15.4%) was the most common skin disorder, followed by papular urticaria (9.97%) and seborrheic dermatitis (8.9%) for which corticosteroids were prescribed. Topical corticosteroids were the most commonly prescribed medications, accounting for 94.1%. The percentage of corticosteroids prescribed by generic name was 82.4%. We found that the percentage of topical corticosteroid prescriptions in fixed drug combinations and extemporaneous prescription was 4.4 and 1.2%, respectively. Mometasone furoate was the most commonly prescribed (34.6%), followed by clobetasol propionate (26.7%). Ointments (53%) followed by creams (40.6%) were the most common formulations of topical corticosteroids issued. In the present study, moderate potency TCS were most commonly prescribed (32.3%), followed by high potency (28.3%), and super high potency (27.6%), respectively.

Conclusion

From this study, it can be concluded that atopic dermatitis is the most common skin disease observed in the studied dermatology outpatient where the corticosteroid was indicated. Mometasone furoate and clobetasol propionate were the two most commonly prescribed agents. Prescribing practice of high potent and very high potent topical corticosteroids was found to be considerably high.
Comparative clinical efficacy of acupuncture combined with manipulation and other non-pharmacological interventions in the treatment of lumbar disc herniation: a prospective, multi-arm, randomized, open-label, blinded endpoint trial
Authors: Shi Fudong , Wen Haibao , Liu Yuzhang , Li Zuoxu , Jin Jiao , Liu Ning , Wang Guojun , Chen Chun , Feng Yadi , Lin Hai , Zhang Shimin
Published: January 2025

Objective

To compare the clinical efficacy and safety of four intervention methods—traditional Chinese manipulation combined with acupuncture, acupuncture alone, manipulation alone, and traction—for the treatment of lumbar disc herniation (LDH).

Methods

A prospective, multi-arm, randomized, parallel-controlled clinical trial was conducted between July 2021 and June 2024. A total of 240 eligible LDH patients were randomized into four groups (60 patients per group) in a 1:1:1:1 ratio: manipulation combined with acupuncture group, manipulation group, acupuncture group, and traction group. Each treatment lasted for 3 weeks. Changes in Visual Analog Scale (VAS) and Japanese Orthopedic Association (JOA) scores were recorded before treatment, at 1 and 3 weeks during treatment, and at 1 and 3 months post-treatment. Adverse events were also monitored.

Results

A total of 210 patients completed the follow-up. At the 3-week (day 21) and 3-month (day 111) follow-ups, the acupuncture + manipulation group showed the most significant improvements, with VAS scores decreasing by 63.34% and 68.30% and JOA scores increasing by 55.17% and 58.33%. The acupuncture group showed VAS score reductions of 55.04% and 59.29% and JOA score increases of 44.52% and 48.29%. The manipulation group reported VAS score reductions of 51.73% and 55.02% and JOA score increases of 41.16% and 45.27%. The traction group demonstrated the least improvement, with VAS scores decreasing by 43.25% and 45.73% and JOA scores increasing by 30.55% and 33.97%. Statistical analysis indicated that the acupuncture + manipulation group had significantly better improvements in VAS and JOA scores than the other three groups during treatment and follow-up periods (P < 0.05). There were no significant differences between the acupuncture and manipulation groups (P > 0.05), while the traction group showed significantly less improvement compared to the other groups (P < 0.05).

Conclusion

This study demonstrates that acupuncture combined with spinal manipulation significantly reduces pain and improves lumbar function in LDH patients compared to other tested interventions. The symptom relief rate was significantly higher in the acupuncture + manipulation group compared to the acupuncture, manipulation, and traction groups.

Clinical trial registration

https://www.chictr.org.cn/index.aspx, identifier ChiCTR2200058598.
Transitioning to a virtual post-intensive care rehabilitation service in response to the COVID-19 pandemic: results of multidisciplinary focus-groups
Authors: Howroyd Fiona , Earle Natacha , Weblin Jonathan , McWilliams David , Raven Mark , Duggal Niharika A. , Ahmed Zubair , Veenith Tonny
Published: January 2025

Background

Telehealth has vastly expanded since the SARS-CoV-2 (COVID-19) pandemic and has been widely implemented as an efficient, cost-effective and accepted means of health care delivery, including rehabilitation. Although telerehabilitation is recommended across national guidelines, there is a lack of practical guidance to support clinicians with virtual adaptations.

Aims

This study aimed to describe the key components of a safe and effective virtual post-intensive-care rehabilitation service, through qualitative exploration.

Methods

This is a qualitative study using a focus-group design based upon grounded theory. This study is nested within a service development project, taking place during the COVID-19 pandemic. Focus groups were held after the first wave of the COVID-19 pandemic with key stakeholders from the physiotherapy and critical care departments of a large tertiary hospital in the United Kingdom. Semi-structured questions were used to guide discussions, led by a facilitator and scribe. Transcripts were thematically analysed using an exploratory inductive approach by two researchers then crosschecked.

Findings

Three focus groups were attended by 12 multidisciplinary stakeholders, including six physiotherapists, two administration staff members, two critical-care follow-up nurses and two critical care consultants. Thematic analysis identified seven critical elements for virtual adaptations: (1) safety and risk assessment, (2) assessment and outcome measures, (3) virtual platform, (4) resources and equipment, (5) exercise programme adaptation, (6) exercise monitoring and safety, and (7) privacy and information governance.

Conclusion

Our findings provide practical recommendations for virtual rehabilitation service development and delivery.
Whole-genome sequencing and secondary metabolite exploration of the novel Bacillus velezensis BN with broad-spectrum antagonistic activity against fungal plant pathogens
Authors: Zheng Yanli , Liu Tongshu , Wang Ziyu , Wang Xu , Wang Haiyan , Li Ying , Zheng Wangshan , Wei Shiyu , Leng Yan , Li Jiajia , Yang Yan , Liu Yang , Li Zhaoyu , Wang Qiang , Tian Yongqiang
Published: January 2025

The utilization of chemical pesticides recovers 30%−40% of food losses. However, their application has also triggered a series of problems, including food safety, environmental pollution, pesticide resistance, and incidents of poisoning. Consequently, green pesticides are increasingly seen as viable alternatives to their chemical counterparts. Among these, Plant Growth-Promoting Rhizobacteria (PGPR), which are found within plant rhizosphere, stand out for their capacity to stimulate plant growth. Recently, we isolated a strain, BN, with broad-spectrum antimicrobial activity from the rhizosphere of Lilium brownii. Identification revealed that this strain belongs to the species Bacillus velezensis and exhibits significant inhibitory effects against various fungal plant pathogens. The complete genome sequence of B. velezensis BN consists of a circular chromosome with a length of 3,929,791 bp, includes 3,747 protein-coding genes, 81 small RNAs, 27 rRNAs, and 86 tRNAs. Genomic analysis revealed that 29% of the genes are directly involved in plant growth, while 70% of the genes are indirectly involved. In addition, 12 putative biosynthetic gene clusters were identified, responsible for the synthesis of secondary metabolites, such as non-ribosomal peptides, lanthipeptides, polyketides, siderophores, and terpenes. These findings provide a scientific basis for the development of efficient antimicrobial agents and the construction of biopesticide production platforms in chassis cells.
Are there distinct subtypes of developmental dyslexia?
Authors: Chalmpe Maria , Vlachos Filippos
Published: January 2025

Introduction

The aim of this study was to identify if children with dyslexia can be distinguished into discrete categories based on their domain deficits, indicating various neurocognitive subtypes of developmental dyslexia (DD).

Methods

The sample included 101 students in the 3rd, 4th, 5th, and 6th grades of primary school (mean age 11.15 years) with a diagnosis of dyslexia from a public center and Greek as their native language. The students underwent tests assessing a wide range of abilities, specifically phonological, memory, attention, processing speed abilities, motor, visual, and visual-motor skills.

Results

Cluster analysis revealed that children with dyslexia can be divided into three subtypes. The first subtype includes children identified based on their performance in tasks evaluating the phonological abilities, memory, attention, processing speed, along with visual-motor and visual skills. The second subtype comprises children identified based on their performance in memory abilities, motor, and visual-motor skills. The third subtype includes children identified solely based on their performance in the motor skills domain.

Discussion

In conclusion, our findings suggest that school-aged children with DD can be categorized into different subtypes with distinct neurocognitive characteristics. Furthermore, the results indicate that most children with dyslexia experience difficulties in more than one cognitive, sensory or motor domains, supporting contemporary models regarding the existence of multiple neurocognitive deficits in DD.
Assessing the fall risk with Stay Independent Questionnaire in people with stroke
Authors: Chen Peiming , Liu T. W. , Ng Shamay S. M.
Published: January 2025

Objectives

This study aimed to assess the psychometric properties of the Chinese version of the Stay Independent Questionnaire (C-SIQ) in evaluating individuals with stroke.

Design

The study adopted a cross-sectional design.

Setting

The research was conducted at a university-based neurorehabilitation center.

Participants

The study included a total of 100 individuals with stroke and 49 healthy older adults.

Methods

On Day 1, both individuals with stroke and healthy older adults underwent assessments using the C-SIQ. Additionally, individuals with stroke were evaluated using the Fugl–Meyer Assessment of Lower Extremity (FMA-LE), ankle dorsiflexion and plantarflexion strength, Berg Balance Scale (BBS), Timed-Up and Go Test (TUG), 10-meter walk test (10 mWT), Activities-specific Balance Confidence (ABC) Scale, Stroke Impact Scale (SIS), and Community Integration Measure (CIM). On Day 2 (7 days after Day 1), individuals with stroke were reassessed using the C-SIQ.

Results

Individuals with stroke exhibited a higher C-SIQ score (6.22 ± 2.98) compared to healthy older adults (1.59 ± 2.01). The C-SIQ demonstrated good test–retest reliability (intraclass correlation coefficient = 0.847) and internal consistency (Cronbach’s alpha = 0.709). The Minimal Detectable Change in C-SIQ score was calculated as 3.05. Exploratory factor analysis revealed four factors with eigenvalues ≥1.0, explaining 57.17% of the total variance. The C-SIQ score exhibited significant correlations (ranging from −0.553 to 0.362) with completion times of the TUG and 10 mWT, FMA-LE, BBS, ABC, SIS, CIM score, paretic ankle dorsiflexion strength, and 6 mWT distance. A cut-off score of 2.5 was identified as the optimal threshold for discriminating fall risk between individuals with stroke and healthy controls.

Conclusion

The C-SIQ emerges as a reliable and valid tool for evaluating fall risk in individuals with stroke, showcasing strong correlations with key measures such as TUG times, 10 mWT, FMA-LE, BBS, ABC, SIS, CIM score, paretic ankle dorsiflexion strength, and 6 mWT distance. The C-SIQ demonstrated good test–retest reliability and internal consistency. Exploratory factor analysis revealed that this is a four factors assessment tool. The identified cut-off score of 2.5 effectively distinguishes fall risk between individuals with stroke and healthy controls.
Association between metabolic score for insulin resistance and stroke: a nationally representative cross-sectional study from NHANES 2007–2018
Authors: Weng Lingtian , Lu Yuqiu , Song Hanning , Xu Jiayi , Jiang Xuhong
Published: January 2025

Background

Stroke is a significant cerebrovascular disease and remains one of the leading causes of death and disability worldwide. Insulin resistance has been strongly linked to the incidence of stroke. Employing characteristics of metabolic syndrome, the Metabolic Score for Insulin Resistance (METS-IR) accurately measures insulin resistance. Nonetheless, the relationship between METS-IR and stroke risk is not well-established.

Methods

We analyzed data from the National Health and Nutrition Examination Survey (NHANES) covering the years 2007–2018. Participants providing complete METS-IR data and self-reported stroke information were included in the study. We utilized weighted multivariate regression to explore the relationship between METS-IR and stroke, performing subgroup analyses as well.

Results

A total of 14,794 participants were included, with an average METS-IR of 43.44 ± 12.68. The overall prevalence of self-reported stroke was 3.79%, with higher rates observed in upper METS-IR tertiles. An increase of one unit in METS-IR was associated with a 1% increase in stroke risk (OR = 1.01; 95% CI: 1.01–1.02). Interaction tests indicated no significant effects of gender, smoking status, alcohol consumption, hypertension, diabetes, physical activity, or serum cholesterol levels on this relationship. Notably, for participants younger than 60 years, the association was significantly stronger (OR = 1.02; 95% CI: 1.01–1.03), with a marked interaction (p = 0.0061).

Conclusion

Our findings indicate a positive correlation between higher METS-IR and increased stroke risk. Early intervention targeting insulin resistance may be a viable preventive measure against stroke, particularly in individuals under 60 years of age.
Association between composite dietary antioxidant index and Epstein–Barr virus infection in children aged 6–19 years in the United States: from the national health and nutrition examination survey 2007–2010
Authors: Cheng Wei , Wang Yunfei , Ding Nan , Xie Rutao
Published: January 2025

Objective

Epstein-Barr virus (EBV) is a globally prevalent herpes virus associated with multiple diseases. Oxidative stress is closely related to EBV infection, latency, reactivation, and transformation. Antioxidant diet protects against EBV infection. Composite Dietary Antioxidant Index (CDAI), serving as a key measure of antioxidant intake, is a summary score of six dietary antioxidants, including vitamins A, C, and E, carotenoid, selenium, and zinc. Despite this, the association between CDAI and EBV infection remains uncertain.

Methods

The aim of the study was to evaluate the association between CDAI and EBV infection using cross-sectional data from 3,318 children aged 6–19 years who participated in the American National Health and Nutrition Examination Survey between 2007 and 2010. Data on EBV results, CDAI, and several other essential variables were analyzed.

Results

Compared with that of individuals in Q3 (−1.627–−0.2727) in the multivariate weighted logistic regression model with full adjustment for confounding variables, the adjusted odds ratio (OR) for CDAI and EBV infection in those in Q1 (−6.613 − −2.9157), Q2 (−2.9158–−1.626), Q4 (−0.2728–1.7601), and Q5 (1.7602–21.419) was 1.41 (95% CI: 1.01–1.96, p = 0.043), 1.10 (95% CI: 0.84–1.45, p = 0.447), 1.14 (95% CI: 0.86–1.51, p = 0.343), and 1.41 (95% CI: 1.01–1.98, p = 0.044), respectively. The association between CDAI and EBV infection showed a U-shaped curve (non-linear; p = 0.002). The OR of reducing EBV infection was 0.882 (95% CI: 0.792–0.982, p = 0.025) in participants with a CDAI of ≤ − 0.81. The OR of developing EBV infection was 1.055 (95% CI: 1.000–1.114, p = 0.050) in participants with a CDAI of > − 0.81.

Conclusion

Our results indicated that the association between CDAI and EBV infection in U.S. adolescents follows a U-shaped curve, with an inflection point around –0.81.This suggests that an antioxidant-rich diet in some amount could help reduce the risk of EBV infection. Future prospective and experimental studies are needed to confirm causality and clarify the exact mechanism concerning antioxidant diets with EBV infection.
Patients’ experiences in early satiety after total gastrectomy for gastric cancer: a phenomenological study
Authors: Vaccaro Salvatore , Díaz Crescitelli Matías Eduardo , Mastrangelo Stefano , Fornaciari Nadia , Reverberi Elisabetta , Di Leo Silvia , Ghirotto Luca
Published: January 2025

Introduction

This study examines how gastric cancer patients adjust their eating habits and quality of life after total gastrectomy, particularly concerning early satiety. While total gastrectomy may provide a potential cure, it also leads to significant physical, psychological, and social changes. Understanding these adaptations is essential for enhancing survivorship care.

Methods

We conducted a qualitative study utilizing a phenomenological approach to gain insights into the lived experiences of gastric cancer patients following total gastrectomy. Semi-structured interviews were analyzed to identify key themes related to eating habits and quality of life.

Results

Four core themes emerged: (1) Ineluctability of bodily transformations—patients experienced significant disruptions to their bodily identity; (2) Feelings of weaning and loss of habits—a sense of mourning for lost routines and pleasures; (3) Redefining habits—the process of adapting to new eating patterns; and (4) Experiencing tentative conviviality—struggles to restore social interactions around meals. Social anxiety, particularly regarding dining outside the home, was a notable challenge. Family caregivers played complex roles, providing both support and unintentional obstacles.

Discussion

The findings highlight the multifaceted impact of total gastrectomy on patients’ lives, influencing their physical health, psychological well-being, and social dynamics. Survivorship care plans should consider these aspects to facilitate adaptation. Targeted interventions, such as nutritional counseling, telemonitoring, and digital tools, are suggested to assist patients in adjusting to post-gastrectomy life. These strategies could enhance quality of life and promote improved physical, psychological, and social well-being integration.
Bioequivalence study of fluticasone propionate nebuliser suspensions in healthy Chinese subjects
Authors: Cheng Feng , Shen Tao , Zhang Fucheng , Lei Chenghao , Zhu Ye , Luo GuoJun , Xiao Dawei
Published: January 2025

Background

Fluticasone propionate is a synthetic trifluoro-substituted glucocorticoid, a highly selective glucocorticoid receptor agonist. Fluticasone propionate nebuliser suspensions is an inhaled corticosteroid with the low systemic bioavailability which provides a low risk (benefit outcome without the adverse effects that accompany systemically administered corticosteroids), referred as a first-line preventive agent for patients with persistent asthma. China has become one of the countries with the highest asthma mortality rate in the world in the past years. It urgently needs good generic drugs to help ease patients’ burden and improve their quality of life.

Objective

The primary objective of this study was to evaluate the bioequivalence of fluticasone propionate nebuliser suspensions between test formulation (generic product) and reference formulation (original product, Flixotide Nebules®) with the pharmacokinetic parameters as the endpoint indicators and the secondary objective was to evaluate the safety of two inhalated fluticasone propionate nebuliser suspensions under the condition of fasting in healthy Chinese subjects.

Methods

The bioequivalence study was conducted with a single-center, randomized, open-label, single-dose, two sequences, two-period crossover design. 24 healthy subjects were randomly assigned into T-R and R-T sequence groups with 12 patients in each group. The subjects were administered 1 mg (2 mL:0.5 mg,plastic ampoules) of generic fluticasone propionate nebuliser suspension as a test formulation or Flixotide Nebules® as reference formulation and cross administration after sufficient washout period (5 days) for the second period study. The blood sample was collected at predetermined time points up to 48 h and the plasma concentration of fluticasone propionate was determined by HPLC-MS/MS in healthy subjects after inhalation of test or reference formulation. The non-compartment model method (NCA module) of the WinNonlin® software (version 8.3) was used to calculate the pharmacokinetic parameters (Cmax, AUC0-t, AUC0-∞) between the test formulation and the reference formulation were within the predefined range of 80.00% and 125.00%, bioequivalence of both formulations was demonstrated.

Results

The 90% confidence intervals of the T/R ratio of the geometric mean of Cmax, AUC0-t, and AUC0-∞ for both formulations were 90.24%–112.68%, 96.99%–112.27% and 96.41%–111.59% respectively, which were all within the bioequivalent range of 80%–125%. No severe, suspicious or unexpected serious adverse reactions were reported.

Conclusion

The test and reference formulations of fluticasone propionate nebuliser suspension were pharmacokinetic bioequivalent and were well tolerated and safe in all subjects.
Network meta-analysis of efficacy and safety of drugs for the treatment of moderate to severe ulcerative colitis
Authors: Zhang Wenkai , Zhao Songbo , Li Jipin , Sun Yihua , Wang Xiang
Published: January 2025

Purpose

To guide the drug selection for treatment of moderate to severe ulcerative colitis (UC) by evaluating the efficacy and safety of various drugs.

Methods

This systematic review searched the Embase, PubMed, The Cochrane Library, and Web of Science databases and included randomized controlled trials (RCTs) based on the drugs used alone or in combination for treating UC. Moreover, the Stata17.0 software was employed for statistical analysis and results were reported as relative risk (RR) and 95% confidence interval (CI).

Results

For the efficacy of induction, upadacitinib ranked first in clinical response, clinical remission, and endoscopic improvement rates, with cumulative probabilities of 96.0%, 99.3%, and 99.0%, respectively. Moreover, for the efficacy of maintenance, upadacitinib ranked first in both clinical remission and endoscopic improvement with a cumulative probability of 93.2% and 93.3%, respectively. For safety, vedolizumab showed the best incidence of adverse events (AE) with 16.8% cumulative probability, while upadacitinib showed the best incidence of serious adverse events (SAE) with 13.8% cumulative probability.

Conclusion

In a systematic review and network meta-analysis, we found upadacitinib showed the best efficacy and safety in to be ranked highest in patients with moderate to severe ulcerative colitis. More trials of direct comparisons are needed to inform clinical decision making with greater confidence.
α-Bisabolol alleviates diesel exhaust particle-induced lung injury and mitochondrial dysfunction by regulating inflammatory, oxidative stress, and apoptotic biomarkers through the c-Jun N-terminal kinase signaling pathway
Authors: Beegam Sumaya , Zaaba Nur Elena , Elzaki Ozaz , Nemmar Abderrahim
Published: January 2025

Introduction

Exposure to particulate matter ≤2.5 μm in diameter (PM2.5) is associated with adverse respiratory outcomes, including alterations to lung morphology and function. These associations were reported even at concentrations lower than the current annual limit of PM2.5. Inhalation of PM2.5, of which diesel exhaust particles (DEPs) is a major component, induces lung inflammation and oxidative stress. α-Bisabolol (BIS) is a bioactive dietary phytochemical with various pharmacological properties, including anti-inflammatory and antioxidant actions. Here, we evaluated the possible protective effects of BIS on DEP-induced lung injury.

Methods

Mice were exposed to DEPs (20 µg/mouse) or saline (control) by intratracheal instillation. BIS was administered orally at two doses (25 and 50 mg/kg) approximately 1 h before DEP exposure. Twenty-four hours after DEP administration, multiple respiratory endpoints were evaluated.

Results

BIS administration was observed to prevent DEP-induced airway hyperreactivity to methacholine; influx of macrophages, neutrophils, and lymphocytes in the bronchoalveolar lavage fluid; and increases in epithelial and endothelial permeabilities. DEP exposure caused increases in the levels of myeloperoxidase, proinflammatory cytokines, and oxidative stress markers in lung tissue homogenates, and all these effects were abated by BIS treatment. The activities of mitochondrial complexes I, II, III, and IV were markedly increased in the lungs of mice exposed to DEPs, and these effects were significantly reduced in the BIS-treated group. Intratracheal instillation of DEPs induced DNA damage and increase in the apoptotic marker cleaved caspase-3. The latter effects were prevented in mice treated with BIS and exposed to DEPs. Moreover, BIS mitigated DEP-induced increase in the expression of phospho-c-Jun N-terminal kinase (JNK) in a dose-dependent manner.

Discussion

BIS markedly alleviated DEP-induced lung injury by regulating the inflammatory, oxidative stress, and apoptotic biomarkers through the JNK signaling pathway. Following additional studies, BIS may be considered as a plausible protective agent against inhaled-particle-induced pulmonary adverse effects.
Miao medicine Tiekuaizi (Radix Chimonanthi): a review of its traditional uses, phytochemistry, pharmacology, and predictive analysis on quality markers
Authors: Luo Li-ying , Zhang Xu-dong , Mei Hui-min , Ma Jian-hui , Peng Xin , Dong Ming-hong , Huang Cong
Published: January 2025

Miao medicine Tiekuaizi (Radix Chimonanthi) has been successfully used by Guizhou Miao ethnic physicians in clinical treatments, demonstrating significant curative effects. The research progress on the resource distribution, traditional uses, phytochemistry, and pharmacology of Tiekuaizi was reviewed by collecting related literature from traditional Chinese medicine books and various databases. Based on the comprehensive review and centered around the principles of traditional Chinese medicine quality marker (Q-Marker) theory, nine secondary metabolites (scopoletin, scopolin, isofraxidin, fraxin, scoparone, calycanthoside, 6, 7, 8-trimethoxycoumarin, tomenin, and calycanthine) are suggested as potential Q-markers for Tiekuaizi to establish quality control standards. This can provide a valuable reference for the collection and processing, pharmaceutical production, and effectiveness and safety of clinical applications of Miao medicine Tiekuaizi.
Modulation of gut microbiota, up-regulation of ZO-1, and promotion of metabolism as therapeutic mechanisms of indole-3-carbinol against obesity in mice
Authors: Mao XuWen , Paerhati Guliruoyi , Wu Yuche , Cheng Lu Feng
Published: January 2025

Background

Indole-3-carbinol (I3C) is a compound derived from Cruciferous vegetables. We aim to ascertain whether I3C mediates the relations between mouse gut microbiota, intestinal barrier function, and metabolism to treat obesity in mice.

Methods

The experimental analyses focused on the changes in lipid distribution, inflammatory cytokines, glucose tolerance, gut microbiota composition, and serum metabolomics of 60 C57BL/6N mice.

Results

The experimental results demonstrated that I3C reduced body weight, hepatic steatosis, and systemic inflammation and improved insulin resistance in mice on a high-fat diet (HFD). Furthermore, I3C remarkably enhanced the enrichment of probiotics Akkermansia and Ligilactobacillus as well as SCFA-producing bacteria (Eubacterium, Lactococcus, and Coprococcus), while reducing the abundance of Eisenbergiella and Rikenellaceae_RC9_gut_group. Also, I3C notably up-regulated the levels of Claudin4, Occludin, and ZO-1 proteins and modulated the metabolism of argininosuccinic acid and galactose.

Conclusion

The aforementioned findings suggest that I3C exerts a significant anti-obesity effect in mice by regulating abnormal gut microbiome, enhancing intestinal barrier function, and improving metabolic disorders.
Pathogenesis-directed therapy of methylphenidate-induced oxidative heart damage in rats
Authors: Emir Izzet , Bulut Seval , Suleyman Bahadır , Mammadov Renad , Yucel Nurinisa , Cicek Betul , Yazici Gulce Naz , Altuner Durdu , Gunay Murat , Suleyman Halis
Published: January 2025

Aim

The current study aimed to investigate the protective effects of adenosine triphosphate (ATP), metyrosine, and melatonin on possible methylphenidate cardiotoxicity in rats using biochemical and histopathological methods.

Methods

Thirty rats were separated into five groups: healthy (HG), methylphenidate (MP), ATP + methylphenidate (ATMP), metyrosine + methylphenidate (MSMP), and melatonin + methylphenidate (MLMP). ATP (5 mg/kg) was given intraperitoneally once daily, metyrosine (50 mg/kg) orally twice daily, and melatonin (10 mg/kg) orally once daily. Methylphenidate (10 mg/kg) was administered orally once daily for 1 h after ATP, metyrosine and melatonin. The protocol was repeated for 30 days. Subsequently, blood samples were taken from the tail veins of the animals to measure adrenaline, noradrenaline, dopamine, troponin I (TP I) and creatine kinase MB (CK-MB) levels; the animals were then euthanized and the heart tissues were extracted. Tissues were analyzed for malondialdehyde (MDA), total glutathione (tGSH), superoxide dismutase (SOD), and catalase (CAT) and histopathologically.

Results

In MP group, MDA, adrenaline, noradrenaline, dopamine, TP I, and CK-MB levels increased (p < 0.001) and tGSH, SOD, and CAT levels decreased (p < 0.001) compared to HG, and histopathologic damage developed. Oxidant levels were lower and antioxidant levels were higher in ATMP, MSMP, and MLMP groups compared to MP group (p < 0.001). Catecholamine levels were measured lower in the MSMP group compared to the MP group (p < 0.001). TP I and CK-MB levels were lower in ATMP, MSMP and MLMP groups compared to MP (p < 0.05), with the lowest being in rats given ATP (p < 0.001). ATP, melatonin, and metirozin applications were effective to different degrees in preventing histopathological changes.

Conclusion

This study may guide clinical trials using ATP and melatonin to prevent methylphenidate-induced myocardial injury.
Current advances on the phytochemistry, pharmacology, quality control and applications of Anoectochilus roxburghii
Authors: Zou Xiaoxue , Zhang Kexin , Li Xuezhen , Zhang Yuqin , Chen Lixia , Li Hua
Published: January 2025

Anoectochilus roxburghii (Wall.) Lindl. (AR) is a perennial herb that has long been used as medicinal and edible plant. In Traditional Chinese Medicine (TCM), AR is utilized to treat various diseases including hyperuricemia, type 2 diabetes mellitus, cancers and inflammatory diseases. Recent advances in the discovery and isolation of bio-active compounds have unveils the main medicinal ingredients, such as quercetin, kinsenoside and rhamnazin. Pharmacological studies further demonstrated its activities, containing anti-inflammation, anti-oxidation, and antihyperlipidemia effects. The processed AR products have various commercial applications in functional foods and cosmetics. AR has been used to prepare soup, drinkbeverage, jelly, face masks, soap, etc. However, despite the abundant medicinal value, it hasn't been included in the 2020 Chinese Pharmacopoeia up to now. There is also no consistent evaluation standard across provinces. This seriously affects the safety and the efficacy of TCM prescriptions, not to mention the development question. This review summarizes recent research on AR in phytochemistry, pharmacology, quality control and applications, raises the corresponding solutions to provide references and potential directions for further studies.
Drug-induced Parkinson-like events: a real-world study from 2004 to the first quarter of 2024 based on FAERS
Authors: Wang Ke , Chen Junyan , Huang Mingquan , Zeng Xinhao , Ren Xiaoqun , Liu Xiuqiong , Tao Chao , Yang Liuxuan , Shang Jinlu , Zhou Meiling
Published: January 2025

Background

Timely identification of drug-induced Parkinson-like events is essential to improve clinical management and enhance patients’ quality of life. However, there is a significant lack of studies addressing these events in real-world settings.

Methods

To bridge this gap, we analyzed adverse event (AE) reports related to Parkinson-like events from the FDA Adverse Event Reporting System (FAERS) database from the first quarter of 2004 to the first quarter of 2024. Our objective was to summarize a list of potential drugs at high risk for Parkinson-like events and their corresponding proportions of AE reports.

Results

As a result, a total of 54,639 AE reports linked to Parkinson-like events involving 1,224 drugs were identified. Among these, carbidopa/levodopa exhibited the highest number of reports, followed by baclofen and pimavanserin. The most frequently reported drug class was antiparkinsonian drugs and psycholeptics, followed by psychoanaleptics. Using two disproportionate analysis methods, the reporting odds ratio and proportional reporting ratio, we found that 136 drugs exhibited positive results in both methods, while 1,063 drugs did not show any positive signals.

Conclusion

This study provides a comprehensive pharmacovigilance analysis of drugs associated with Parkinson-like events, aiming to promote rational drug use and inform clinical practice.
Game-theoretic analysis of the impact of differential leadership on employee silence behavior in Chinese family enterprises
Authors: Lu Jie , Yang Ting , Qin Yi , Hu Xinting
Published: January 2025

In the VUCA (Volatility, Uncertainty, Complexity, and Ambiguity) era, there is growing concern about the impact of differential leadership, a leadership style with localized characteristics, on employee perspectives and recommendations. This study constructs a dynamic game model to examine the influence of differential leadership on the silence behavior of insiders (employees perceived as close to the leader) and outsiders (employees perceived as distant from the leader). The results of the study found that both insiders and outsiders who want to achieve and sustain benefits need to demonstrate non-silent behaviors in order to gain the attention and goodwill of the leader. Insiders’ self-efficacy, outsiders’ out-group preference and employees’ proactive personality are the key factors driving their non-silence behaviors, constructing a constructive atmosphere in the organization, and bringing perceived benefits. This study provides relevant insights and reflections for the high-quality development of family enterprises. This study, on the one hand, addresses the research gap concerning self-perceived benefits and out-group favoritism within the organizational framework of family businesses against the backdrop of Chinese traditional culture. It establishes an analytical framework for the impact of “differential leadership-self-perceived benefits/out-group favoritism-employee silence behavior” in family businesses. On the other hand, it focuses the research lens on the relatively novel topic of the theoretical and practical examination of the relationship between differential leadership and employee silence behavior in family businesses. From a micro perspective, this study offers a new direction for Chinese family businesses to alleviate employee silence behavior and successfully achieve transformation.
Meta-analyses of the effects of high-intensity interval training in elite athletes—part I: mean effects on various performance measures
Authors: Wiesinger Hans-Peter , Stöggl Thomas Leonard , Haller Nils , Blumkaitis Julia , Strepp Tilmann , Kilzer Francesca , Schmuttermair Anna , Hopkins Will G.
Published: January 2025

Introduction

Meta-analysts have found that high-intensity interval training (HIIT) improves physical performance, but limited evidence exists regarding its effects on highly trained athletes, measures beyond maximum oxygen uptake (V˙O2max), and the moderating effects of different types of HIIT. In this study, we present meta-analyses of the effects of HIIT focusing on these deficits.

Methods

The effects of 6 types of HIIT and other moderators were derived from 34 studies involving highly trained endurance and elite athletes in percent units via log-transformation from separate meta-regression mixed models for sprint, time–trial, aerobic/anaerobic threshold, peak speed/power, repeated-sprint ability, V˙O2max, and exercise economy. The level of evidence for effect magnitudes was evaluated based on the effect uncertainty and the smallest important change of 1%.

Results

Compared with control training, HIIT showed good to excellent evidence for the substantial enhancement of most measures for some athlete subgroups in practically important study settings defined by effect moderators (maximum of 12.6%, for endurance female athletes after 6 weeks of aerobic traditional long intervals). The assessment of the moderators indicated good evidence of greater effects as follows: with more aerobic types of HIIT for V˙O2max (+2.6%); with HIIT added to conventional training for most measures (+1.1–2.3%); during the competition phase for V˙O2max (+4.3%); and with tests of longer duration for sprint (+5.5%) and time trial (+4.9%). The effects of sex and type of athlete were unclear moderators. The heterogeneity of HIIT effects within a given type of setting varied from small to moderate (standard deviations of 1.1%–2.3%) and reduced the evidence of benefit in some settings.

Conclusion

Although athletes in some settings can be confident of the beneficial effects of HIIT on some measures related to competition performance, further research is needed. There is uncertainty regarding the mean effects on exercise economy and the modifying effects of sex, duration of intervention, phase of training, and type of HIIT for most measures.

Systematic Review Registration

https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=236384.
Welfare state, social policy and social sustainability, within the context of the permacrisis
Authors: Papadakis Nikos , Tzagkarakis Stylianos Ioannis
Published: January 2025

Introduction

Sustainable development is based on three interrelated and equally important pillars; the environmental, the economic and the social. The social pillar involves building a framework that promotes the well-being of the whole population with the ultimate aim of preserving social cohesion, while reducing social discrimination. In our analysis, the concept of social sustainability refers to the need for the creation of a society that contains all the conditions for sustainable development in terms of equal opportunities for employment and social well-being. Currently, significant problems and dysfunctions exist as long as several European labor markets are fragmented with a strong insiders-outsiders divergence, job-polarization, high labor market slack, high in-work poverty rates especially in precarious forms of employment. In Europe as well as globally, addressing these issues is of major importance in order to ensure social sustainability, given that the permacrisis (multiple crises), along with the Mega-Trends have a clear impact on the structure of economy and labor market, industrial relations systems, and business models.

Methods

The present paper analyses the state of play of social sustainability in Europe and aims to identify specific policy responses that could offer viable solutions to old and emerging challenges in terms of social inclusion through the examination of secondary quantitative data.

Results

The permacrisis era, along with the Mega-Trends that are taking place and seem to gradually have a clear impact on the structure of economy and labor market, substantially affecting every aspect of society, since social inequalities have the tendency to interrelate and getting reproduced.

Discussion

There is a need for knowledge-based and evidence-informed policy making, both in terms of policy design and implementation, for a true and actual sustainable (as well as inclusive) development, within momentous times.
Effects of therapeutic alliance on patients with major depressive disorder: a literature review
Authors: Videtta Giovanni , Busilacchi Silvia , Bartoccioni Giulia , Cirella Luisa , Barone Ylenia , Delvecchio Giuseppe
Published: January 2025

Therapeutic alliance refers to the collaborative relationship between a therapist and a patient, a concept widely explored in clinical research. It has emerged as a crucial component of effective psychotherapeutic interventions, particularly in the treatment of major depressive disorder (MDD), where its role appears to be multifaceted. In this context, we reviewed the main literature on the role of therapeutic alliance in MDD. The record search was conducted across three databases: PubMed, Web of Science, and PsychInfo. Seven of the reviewed studies highlighted that therapeutic alliance is a strong predictor of clinical outcomes, contributing to symptom improvement, relapse prevention, and more adaptive functioning in patients with MDD. However, three studies supported the hypothesis that clinical improvement itself might influence the therapeutic alliance between a therapist and a patient at different stages of treatment. Overall, the results suggest a bidirectional relationship between therapeutic alliance and symptom improvement, indicating that a stronger alliance often predicts better outcomes and symptom reduction can further enhance the alliance. However, the interpretation of these results must consider certain methodological limitations. These include the use of different approaches, measurements, and clinical outcomes to assess therapeutic alliance, as well as insufficient exploration of the temporal precedence between therapeutic alliance and clinical outcomes. In conclusion, future studies are warranted to address these limitations and further clarify the role of therapeutic alliance in MDD, along with its potential implications for clinical practice.
The psychological resources of success: satisfaction with academic majors, psychological capital, and achievement motivation among future tourism and hospitality leaders
Authors: Alismail Abdulaziz Mohammed , Almulla Mazen Omar , Albohnayh Abdullah Saleh Mohammed , Abdou Ahmed Hassan
Published: January 2025

Introduction

Exploring the factors that drive academic achievement motivation is a vital area in educational psychology, particularly within specialized fields like tourism and hospitality higher education. Achievement motivation, essential for academic and career success, is shaped by various positive psychological resources and contextual factors. Grounded in the framework of positive psychology, this study examines how satisfaction with academic majors (SAT) predicts achievement motivation among tourism and hospitality students in Saudi Arabia. Additionally, the research investigates the mediating role of psychological capital (PsyCap) - a positive psychological construct encompassing hope, optimism, resilience, and self-efficacy - within this relationship.

Methods

A quantitative approach was employed using Partial Least Squares Structural Equation Modeling (PLS-SEM). Data were collected from 522 junior and senior undergraduate students enrolled in tourism and hospitality programs across Saudi Arabia. Validated scales were used to measure SAT, PsyCap, and achievement motivation.

Results

The findings indicate that greater satisfaction with one’s academic major (SAT) positively predicts both PsyCap and achievement motivation. Furthermore, PsyCap was found to be positively and significantly associated with achievement motivation and partially mediate the relationship between SAT and achievement motivation.

Conclusion

This study’s findings underscore the vital role of positive psychological resources in empowering students and advancing motivation, offering a validated model that informs future educational studies and interventions within tourism and hospitality while underscoring the significance of fostering psychological well-being in higher education.