bluuebunny/crossref_metadata_2025 huggingface dataset:
Development and validation of a promising 5-gene prognostic model for pediatric acute myeloid leukemia
Authors: Tao Yu , Wei Li , Shiba Norio , Tomizawa Daisuke , Hayashi Yasuhide , Ogawa Seishi , Chen Li , You Hua
Published: January 2024

Risk classification in pediatric acute myeloid leukemia (P-AML) is crucial for personalizing treatments. Thus, we aimed to establish a risk-stratification tool for P-AML patients and eventually guide individual treatment. A total of 256 P-AML patients with accredited mRNA-seq data from the TARGET database were divided into training and internal validation datasets. A gene-expression-based prognostic score was constructed for overall survival (OS), by using univariate Cox analysis, LASSO regression analysis, Kaplan–Meier (K-M) survival, and multivariate Cox analysis. A P-AML-5G prognostic score bioinformatically derived from expression levels of 5 genes (ZNF775, RNFT1, CRNDE, COL23A1, and TTC38), clustered P-AML patients in training dataset into high-risk group (above optimal cut-off) with shorter OS, and low-risk group (below optimal cut-off) with longer OS (p < 0.0001). Meanwhile, similar results were obtained in internal validation dataset (p = 0.005), combination dataset (p < 0.001), two treatment sub-groups (p < 0.05), intermediate-risk group defined with the Children's Oncology Group (COG) (p < 0.05) and an external Japanese P-AML dataset (p = 0.005). The model was further validated in the COG study AAML1031(p = 0.001), and based on transcriptomic analysis of 943 pediatric patients and 70 normal bone marrow samples from this dataset, two genes in the model demonstrated significant differential expression between the groups [all log2(foldchange) > 3, p < 0.001]. Independent of other prognostic factors, the P-AML-5G groups presented the highest concordance-index values in training dataset, chemo-therapy only treatment subgroups of the training and internal validation datasets, and whole genome-sequencing subgroup of the combined dataset, outperforming two Children's Oncology Group (COG) risk stratification systems, 2022 European LeukemiaNet (ELN) risk classification tool and two leukemic stem cell expression-based models. The 5-gene prognostic model generated by a single assay can further refine the current COG risk stratification system that relies on numerous tests and may have the potential for the risk judgment and identification of the high-risk pediatric AML patients receiving chemo-therapy only treatment.
The epidemiology of notifiable diseases in Australia and the impact of the COVID-19 pandemic, 2012–2022
Authors: Sohail Asma , Cheng Allen C. , McGuinness Sarah L. , Leder Karin
Published: January 2024

Background

Infectious disease surveillance tracks disease epidemiology and informs prevention and control. Public health measures implemented in Australia during the COVID-19 pandemic (2020 to 2022) affected infectious disease epidemiology. We examined notifiable disease epidemiology in Australia from 2012 to 2022, evaluating disease trends and pandemic impacts.

Methods

We analysed case notifications supplied to the Australian National Notifiable Disease Surveillance System (NNDSS) from 1 January 2012 to 31 December 2022. The annual incidence and notification incidence trends were calculated and the average changes in annual incidence were investigated by Poisson regression.

Results

Over the study period, there were 14,087,045 notifications of 68 diseases. Respiratory diseases were the most commonly notified disease group (83% of all notifications) and vector-borne diseases the least (< 1%). The ten highest-incidence diseases comprised 97% of all notifications over the study period, with COVID-19 alone accounting for 72%. Notifications were most common among the 20–39-year age group (37%). From 2012–2019, notification incidence of gastrointestinal, respiratory and sexually transmissible infections increased, whereas for bloodborne viral hepatitis, vector-borne diseases and imported diseases it decreased. From 2020–2021, average notification incidence of most non-COVID-19 respiratory diseases decreased compared to the 2012–2019 period; sexually transmissible infections notification incidence remained fairly stable; notification incidence of some gastrointestinal diseases increased while others decreased; and notification of imported diseases markedly decreased. A rebound in notification incidence was seen for most diseases in 2022.

Conclusions

Prior to the COVID-19 pandemic, most notifiable diseases had increasing notification incidence, except for bloodborne viral hepatitis, vector-borne diseases and imported diseases. COVID-19-related public health measures had variable impacts on notifiable diseases.
Introduction to this special section: Microseismic monitoring
Authors: Le Calvez Joël , Ay Erkan
Published: January 2024

Microseismic monitoring is an important technique for understanding the behavior of subsurface structures and assessing the risks associated with human activities that can induce seismic events. However, it is also a challenging problem due to the low-energy radiation of the microseismic events, which can make them difficult to detect and locate accurately. In recent years, several innovations in technology and data analysis have addressed the limitations faced in the past.
Advances in hydraulic fracture characterization via borehole microseismic and strain monitoring
Authors: Altowairqi Yazeed , Alqatari Hala , Colombo Daniele , Turkoglu Ersan
Published: January 2024

We analyze the impact and challenges associated with microseismic monitoring in the development of unconventional reservoirs. We detail advanced methods that address some of these challenges and discuss emerging data analysis and acquisition technologies such as those provided by fiber-optic monitoring. During the development of unconventional resources, it is important to understand the stimulated rock volume obtained from the hydraulic fracturing treatment. Microseismic monitoring is one of the sources of information for estimating stimulated rock volume in which accurate hypocenter calculations provide the horizontal and vertical fracture geometry and extent. We developed hypocenter waveform-based relocation and collapsing techniques and demonstrated these on synthetic and field data to obtain an enhanced description of the fracture geometry. We further provide the initial analysis of a recently acquired data set composed of multiple monitoring wells instrumented with geophones and fiber optics operating simultaneously. Microseismic events recorded by the multiwell dual geophone/fiber setup show meaningful signal-to-noise ratio to enable a joint interpretation. Additional strain and temperature data provided by dynamic fiber-optic measurements extend the interpretation capabilities of the hydraulic fracturing phenomenon while providing an avenue for advanced research on fracture characterization.
Archaeological geophysical investigation of Uzun Rama Steppe kurgans, Goranboy
Authors: Bayramov Kamal , Alizada Gunel , Mammadov Sarvar , Azimov Vusal , Abdullayev Malik , Jodry Clara , Bano Maksim
Published: January 2024

Geophysical methods can provide valuable information when imaging man-made subsurface structures prior to archaeological excavations. An archaeological geophysical survey was conducted on funeral chambers (also known as kurgans) from the Early Bronze Age, in the Shadili-Uzun Rama Steppe of the Goranboy region, near the Kurakchay river gorge in Azerbaijan. This multimethod survey is based on a ground-penetrating radar profile, heat map of the total magnetic intensity, and contiguous profiles of electrical resistivity and seismic refraction. Brief processing and default inversion methods enabled us to obtain geophysical images in accordance with the lithology (a subsoil comprised of alluvial-proluvial conglomerate terrasse). The shape of the kurgans was recovered mainly through electrical resistivity tomography, enabling future targeted excavations. Overall, this study further testifies that geophysics provides valuable information for archaeological investigations, although higher resolution could be achieved by using more advanced field methodology and processing.
Myths and Common Misbeliefs About Colorectal Cancer Causation in Palestine: A National Cross-Sectional Study
Authors: Elshami Mohamedraed , Naji Shoruq Ahmed , Dwikat Mohammad Fuad , Al-Slaibi Ibrahim , Alser Mohammed , Ayyad Mohammed , Mohamad Balqees Mustafa , Isleem Wejdan Sudki , Shurrab Adela , Yaghi Bashar , Qabaja Yahya Ayyash , Hamdan Fatma Khader , Sweity Raneen Raed , Jneed Remah Tayseer , Assaf Khayria Ali , Albandak Maram Elena , Hmaid Mohammed Madhat , Awwad Iyas Imad , Alhabil Belal Khalil , Alarda Marah Naser , Alsattari Amani Saleh , Aboyousef Moumen Sameer , Aljbour Omar Abdallah , AlSharif Rinad , Giacaman Christy Teddy , Alnaga Ali Younis , Abu Nemer Ranin Mufid , Almadhoun Nada Mahmoud , Skaik Sondos Mahmoud , Bottcher Bettina , Abu-El-Noor Nasser
Published: January 2024

PURPOSE

To explore public awareness of myths around colorectal cancer (CRC) causation in Palestine and to examine factors associated with good awareness.

MATERIALS AND METHODS

Convenience sampling was used to recruit adult Palestinians from governmental hospitals, primary health care centers, and public spaces. Recognizing 13 myths around CRC causation was assessed using a translated-into-Arabic version of the Cancer Awareness Measure-Mythical Causes Scale. Awareness level was determined based on the number of CRC mythical causes recognized: poor (0-4), fair (5-9), and good (10-13). Multivariable logistic regression was used to examine the association between sociodemographic characteristics and displaying good awareness. It adjusted for age group, sex, education, occupation, monthly income, residence, marital status, having chronic diseases, being a vegetarian, knowing someone with cancer, and site of data collection.

RESULTS

Of 5,254 participants approached, 4,877 agreed to participate (response rate, 92.3%). A total of 4,623 questionnaires were included in the final analysis: 2,700 from the West Bank and Jerusalem (WBJ) and 1,923 from the Gaza Strip. Only 219 participants (4.7%) demonstrated good awareness of myths around CRC causation. WBJ participants were twice more likely than those from the Gaza Strip to display good recognition (5.9% v 3.1%). Male sex, living in the WBJ, and visiting hospitals were all associated with an increase in the likelihood of displaying good awareness. Conversely, knowing someone with cancer was associated with a decrease in the likelihood of displaying good awareness. Having a physical trauma was the most recognized CRC causation myth (n = 2,752, 59.5%), whereas eating food containing additives was the least (n = 456, 9.8%).

CONCLUSION

Only 4.7% displayed good ability to recognize myths around CRC causation. Future educational interventions are needed to help the public distinguish the evidence-based versus mythical causes of CRC.
Quantum control by effective counterdiabatic driving
Authors: Petiziol Francesco , Mintert Florian , Wimberger Sandro
Published: January 2024

We review a scheme for the systematic design of quantum control protocols based on shortcuts to adiabaticity in few-level quantum systems. The adiabatic dynamics is accelerated by introducing high-frequency modulations in the control Hamiltonian, which mimic a time-dependent counterdiabatic correction. We present a number of applications for the high-fidelity realization of quantum state transfers and quantum gates based on effective counterdiabatic driving, in platforms ranging from superconducting circuits to Rydberg atoms.
Clinical Characteristics and Outcomes of Prolactinomas in Children and Adolescents: A Large Retrospective Cohort Study
Authors: Yang Yiying , Ke Xiaoan , Duan Lian , Yang Hongbo , Gong Fengying , Pan Hui , Wang Linjie , Zhu Huijuan
Published: January 2024

Context

Prolactinoma, the most common subtype of pituitary adenoma, is rare in children and adolescents. Clinical presentation and treatment outcomes of prolactinomas in this population have been evaluated insufficiently.

Objective

To summarize the clinical features, both medication and surgical outcomes of prolactinomas in children and adolescents in a large retrospective cohort from China.

Methods

A cohort of patients with prolactinomas aged ≤20 years at diagnosis between 2012 and 2021 in Peking Union Medical College Hospital were retrospectively analyzed.

Results

The cohort comprised 170 patients (115 females and 55 males, median age 16.6 years), with 20.0% (23/115) girls without menarche and 33.3% (18/54) boys in prepuberty. The median maximal diameter was 15.0 mm (61.2% macroadenomas and 4.6% giant adenomas), and the median baseline prolactin (PRL) level was 211.0 ng/mL. Larger sizes and higher PRL levels were observed in girls without menarche at diagnosis and in boys. Most girls presented with menstrual disturbance (86.7%), and boys were frequently bothered by headaches (42.6%), reduced height velocities (25.9%), and delayed puberty (18.2%). Dopamine agonists (DAs) were used as first-line treatment in 133 patients, and the resistance rate was 22.5% (25/111), independently associated with maximal tumor diameters (P = .035). Surgery was performed in 76 patients. Long-term surgical remission rates were 32.9% (25/76) overall, negatively associated with cavernous sinus invasion independently (P = .025), 59.4% (19/32) in noninvasive tumors (64.0% in 25 noninvasive macroadenomas), and 5.0% (1/20) in invasive tumors.

Conclusion

Pediatric prolactinomas exhibited more severe clinical characteristics in boys and in patients diagnosed during earlier stages of pubertal developments. Given the overall efficacy of PRL normalization by medication and considerable surgical remission rate in noninvasive tumors, DAs remain the first-line recommendation for prolactinomas in children and adolescents, while surgery might be viable for noninvasive tumors.
KNDy Neurons of the Hypothalamus and Their Role in GnRH Pulse Generation: an Update
Authors: Moore Aleisha M , Novak Alyssa G , Lehman Michael N
Published: January 2024

There is considerable evidence that synchronized activity within a reciprocally connected population of cells in the arcuate nucleus (ARC) coexpressing kisspeptin, neurokinin B (NKB), and dynorphin (KNDy cells) is crucial for the generation of gonadotrophin-releasing hormone (GnRH) pulses in mammals. The initial “KNDy hypothesis” proposed that pulsatile GnRH secretion is elicited by episodic kisspeptin release from KNDy cells following synchronized activation and termination of the population by NKB and dynorphin, respectively. Since then, the role of KNDy cells as a critical component of the pulse generator has been further supported by studies at the single-cell level, demonstrating that the population is both necessary and sufficient for pulsatility. In addition, there have been considerable modifications and expansion of the original hypothesis, including work demonstrating the critical role of glutamate in synchronization of the KNDy cell network, functional interactions with other ARC subpopulations, and the existence of species differences in the role of dynorphin in pulse generation. Here we review these recent changes and discuss how the translation of these findings has led to the development of new therapies for disorders related to pulse generation. We also outline critical gaps in knowledge that are currently limiting the application of KNDy research in the clinic, particularly regarding the role of dynorphin in pulse generation in primates.
Invasive Testing for Preoperative Localization of Parathyroid Tumors
Authors: Graf Akua , Cochran Craig , Sadowski Samira , Nilubol Naris , Simonds William F , Weinstein Lee S , Chang Richard , Jha Smita
Published: January 2024

Context

The identification of parathyroid tumor(s) in patients with persistent/recurrent primary hyperparathyroidism (PHPT) is critical for a successful reoperative surgery. If noninvasive studies (ultrasound, computed tomography, magnetic resonance imaging, sestamibi) fail to conclusively localize the tumor, invasive procedures (arteriography and selective venous sampling) are performed.

Objective

To describe our experience with invasive studies for parathyroid tumor localization and provide follow-up data on selective arterial hypocalcemic stimulation with central venous sampling, a technique developed at our center.

Methods

We identified patients who underwent preoperative invasive testing for localization of parathyroid tumor from 1991 to 2020. The result of each invasive localization study [arteriogram, hypocalcemic stimulation and selective venous sampling (SVS)] was categorized as true-positive, false-positive, and false-negative based on histology and biochemical outcome.

Results

Ninety-four patients with 96 tumor occurrences underwent invasive testing for parathyroid tumor localization. Arteriogram, hypocalcemic stimulation, and SVS accurately localized the tumor in 47 of 94 (50%), 56 of 93 (60%), and 51 of 62 (82%) tumors, respectively. Hypocalcemic stimulation was more likely to correctly localize the tumor when arteriogram showed a blush [37 of 50 (74%) vs 19 of 43 (44%), P = .01]. When both arteriogram and hypocalcemic stimulation yielded concordant positive findings, SVS did not change management in the 18 cases in which all 3 were performed. Twelve patients remained with persistent PHPT; all had recurrent disease with multiple affected glands.

Conclusion

Hypocalcemic stimulation is a useful adjunct in patients with PHPT who require invasive localization and can obviate the need for SVS.

Clinical Trial number: NCT04969926
RhoA GEF Mcf2lb regulates rosette integrity during collective cell migration
Authors: Olson Hannah M. , Maxfield Amanda , Calistri Nicholas L. , Heiser Laura M. , Qian Weiyi , Knaut Holger , Nechiporuk Alex V.
Published: January 2024

Multicellular rosettes are transient epithelial structures that serve as important cellular intermediates in the formation of diverse organs. Using the zebrafish posterior lateral line primordium (pLLP) as a model system, we investigated the role of the RhoA GEF Mcf2lb in rosette morphogenesis. The pLLP is a group of ∼150 cells that migrates along the zebrafish trunk and is organized into epithelial rosettes; these are deposited along the trunk and will differentiate into sensory organs called neuromasts (NMs). Using single-cell RNA-sequencing and whole-mount in situ hybridization, we showed that mcf2lb is expressed in the pLLP during migration. Live imaging and subsequent 3D analysis of mcf2lb mutant pLLP cells showed disrupted apical constriction and subsequent rosette organization. This resulted in an excess number of deposited NMs along the trunk of the zebrafish. Cell polarity markers ZO-1 and Par-3 were apically localized, indicating that pLLP cells are properly polarized. In contrast, RhoA activity, as well as signaling components downstream of RhoA, Rock2a and non-muscle Myosin II, were diminished apically. Thus, Mcf2lb-dependent RhoA activation maintains the integrity of epithelial rosettes.
Choose Development in 2024: serious science, community connections, progressive publishing
Authors: Briscoe James , Brown Katherine
Published: January 2024

Summary: Looking back on Development in 2023 and forwards to 2024, we call on authors to support the community through supporting the journal.
Personal Experience of Suffering
Authors: Gudaniec Arkadiusz
Published: January 2024

Using elements of K. Wojtyła’s philosophical anthropology, I make an attempt to look at the phenomenon of suffering through the experience of the suffering subject, through the uniquely personal experience of ‘I am suffering.’ The personal experience of suffering involves the inclusion of the phenomena of pain and suffering within the domain of self-consciousness, i.e. within the field of experiencing oneself, the sense of one's own identity, including the striving for fulfilment. In this perspective, the experience of suffering has to do with the person-specific openness to transcendence, which makes it possible to show the positive side to the experience of suffering. Both in the field of self-consciousness and in the personal experience of self-determination, the experience of ‘I am suffering’ can serve the person in the realisation of personal truth (about the good), involving and stimulating actions towards fulfilment.
PRZYCZYNY POJAWIENIA SIĘ WIZERUNKU CHRYSTUSA W MENNICTWIE CESARZA JUSTYNIANA II (PAN. 685–695, 705–711)
Authors: Wojcieszak Maciej
Published: January 2024

W artykule zająłem się omówieniem przyczyn, dla których Justynian II (pan. 685–695, 705–711) rozpoczął wybijanie monet z wizerunkiem Chrystusa. Było to wydarzenie dość znaczące w ikonografi i mennictwa bizantyńskiego, ponieważ o ile monety ze znakami chrześcijańskimi pojawiały się już od czasów Konstantyna Wielkiego, o tyle po raz pierwszy popiersie Chrystusa na wybijanych monetach pojawiło się ok. 691/692 roku. Przyczyny, które analizuję, związane są z: 1. Wsparciem soboru trullańskiego (lub inaczej: synodu quinisextum) oraz uchwalonym na nim kanonem 82, nakazującym przedstawiać Chrystusa jako człowieka; 2. Ekspansją arabską abd al-Malika oraz sprowokowaniem go do wojny poprzez odrzucenie trybutu płatnego w innych monetach niż tych z wizerunkiem cesarza i Chrystusa (w islamie wszelkie wizerunki ludzkie były zakazane); 3. Legitymizacją władzy cesarskiej, szczególnie w drugim okresie panowania Justyniana II. Temat, który podjąłem, jest jednocześnie zachętą do dyskusji naukowej związanej ze wczesnośredniowiecznym mennictwem bizantyńskim.
New Spirituality: A Viable Alternative?
Authors: Perszon Jan
Published: January 2024

Nowa duchowość – realna alternatywa?
W opinii wielu myślicieli kultura Zachodu (czyli tzw. cywilizacja chrześcijańska) od dziesięcioleci przeżywa głęboki kryzys. Jednym z symptomów tej transformacji jest szybkie (i jak się wydaje – nieodwracalne) słabnięcie chrześcijaństwa, zwłaszcza w jego warstwie religijnej, czyli zorganizowanej w Kościołach. Niniejszy tekst jest próbą ukazania (m.in. w nauczaniu Jana Pawła II i Benedykta XVI) przyczyn tych zmian. Następnie zaś podejmuje kwestię nowej duchowości, która – co jest widoczne zwłaszcza w badaniach socjologicznych – zajmuje przestrzeń, „opróżnioną” z żywej wiary i praktyk religijnych. Odejście większości społeczeństwa od zorganizowanej religii nie oznacza powszechnej rezygnacji z życia duchowego. To w „nowej duchowości” coraz liczniejsi Europejczycy i Amerykanie „realizują” nieodpartą potrzebę egzystowania w sferze sacrum, doświadczania Absolutu bądź też zanurzenia się w różnie pojmowanej (i rytualnie celebrowanej) boskości. Upowszechnianie się alternatywnej duchowości jest wyzwaniem dla Kościoła i jego zbawczej misji. Każe też postawić pytanie, czy jest ona rzeczywistą (konkurencyjną) alternatywą dla bogatej i przez wieki sprawdzonej tradycji duchowości chrześcijańskiej.
Edukacja regionalna w polskiej szkole. Ścieżka kaszubska – studium przypadku
Authors: Cichosz Wojciech
Published: January 2024

Tradycja i kultura są spoiwem, które łączy kolejne pokolenia zamieszkujące dane terytorium. Ta prawda wyraźnie objawia się w przypadku Kaszub, regionu leżącego w północnej Polsce. Zamieszkującą go społeczność jednoczy ponadto własny język, którym posługuje się w relacja rodzinnych, sąsiedzkich, a nawet urzędowych. Z uznaniem należy stwierdzić, że miejscowa ludność docenia fakt oficjalnego przyznania etnogwarze statusu języka regionalnego. Przemiany społeczno-polityczne końca XX wieku dały Kaszubom możliwość jawnego pielęgnowania tożsamości kulturowej i przyczyniły się do promocji wielowymiarowego bogactwa tego regionu. Wyrazem wspomnianych przemian jest możliwość nauczania języka kaszubskiego w szkole. Obowiązujące w polskim szkolnictwie normy prawa, jak również ustawa o mniejszościach narodowych z 2005 roku oraz Europejska karta języków regionalnych lub mniejszościowych dają młodym Kaszubom możliwość uczenia się w szkole języka kaszubskiego, własnej historii i kultury. Realizację tego pragnienia zapewniają zarówno środki finansowe przekazywane z budżetu państwa na ten cel organom prowadzącym szkoły, jak też dobrze przygotowana na etnofilologii kaszubskiej Uniwersytetu Gdańskiego kadra. Przykładem szkoły, w której z sukcesem naucza się języka kaszubskiego jest Katolicka Szkoła Podstawowa im. św. Jana Pawła II w Gdyni. Dzieci uczą się języka podczas zajęć w budynku szkoły, poznają też kulturę, historię i specyfikę życia podczas wyjazdów terenowych. W edukację regionalną realizowaną w ramach tzw. „ścieżki kaszubskiej” angażują się również rodzice. Uczniowie z dumą reprezentują szkołę i region podczas oficjalnych uroczystości w placówce i poza nią.
Normalized solutions for the Schrödinger-Poisson system with doubly critical growth
Authors: Meng Yuxi , He Xiaoming
Published: January 2024

In this paper we are concerned with normalized solutions to the
Schrödinger-Poisson system with doubly critical growth
\[
\begin{cases}
-\Delta u-\phi |u|^3u=\lambda u+\mu|u|^{q-2}u+|u|^4u, &x \in \R^{3},\\
-\Delta \phi=|u|^5, &x \in \R^{3},
\end{cases} \]
and prescribed mass
\[ \int_{\R^3}|u|^2dx=a^2,\]
where $a> 0$ is a constant, $\mu> 0$ is a parameter and $2< q< 6$. In
the $L^2$-subcritical case, we study the multiplicity of normalized
solutions by applying the truncation technique, and the genus
theory; and in the $L^2$-supercritical case, we obtain a couple of
normalized solutions by developing a fiber map. Under both cases, to
recover the loss of compactness of the energy functional caused by
the critical growth, we need to adopt the concentration-compactness
principle. Our results complement and improve some related studies for
the Schrödinger-Poisson system with nonlocal critical term in
the literature.
La importancia de lo representado. Editorial del número 15(1)
Authors: Marcos Ramos María , González de Garay Beatriz
Published: January 2024

Editorial del número 15(1). Enero-Junio, 2022
Analysis of Productivity Measurement in CPO Production Using OMAX Method
Authors: Sakti Ade Dwi , Hartati Misra , Nur Muhammad , Harpito Harpito
Published: January 2024

The primary focus of this research revolves around the measurement of productivity and the factors that impact Crude Palm Oil (CPO) production which currently faces challenges in assessing whether existing productivity falls into the 'satisfactory' category. The contribution of this study is conducting a comprehensive productivity assessment, focusing on metrics and identifying the causes of productivity decline, especially potential points of failure. The measurement indicators use the Objective Matrix (OMAX) method which includes five ratios, including raw material utilization, energy consumption, labor efficiency, optimization of production targets, and production capacity utilization. The Analytical Hierarchy Process (AHP) is used to assign relative weight to factors that contribute to overall productivity. In addition, Failure Modes and Effects Analysis (FMEA) functions as a tool to determine the causes of decreased productivity by considering the potential for failure to occur. The research results show that productivity reached its highest point in March at 219.93% and the lowest in July at -67.33%. Based on the score assessment, this decline was mainly caused by the lack of optimal achievement of production targets, symbolized by a ratio of 4 to a score of 45. Potential causes for this ratio include non-compliance in selecting FFB that meets standards, and production standards that are too ambitious. targets, and mental and physical fatigue and stress. To improve overall performance, proposed improvements include the application of Internet of Things (IoT) technology, such as the use of sensors and automation systems in production processes, as well as investment in agricultural technology as a monitoring system. This increase is aimed at achieving higher production targets and overall efficiency.
Designing the Decision Support System to Determine the Major and Higher Education Institution based on Preferences of Prospective Students
Authors: Astutik Siti Supri , Jatiningrum Wandhansari Sekar
Published: January 2024

There are several factors considered by students toward determining the major and higher education institution. As a result, determining the best choices for further studies becomes difficult. Moreover, there are many choices of higher education. This study contributes to developing a decision support system (DSS) to help students determine the major and higher education institution considered several criteria based on Analytical Hierarchy Process (AHP). Several criteria and subcriteria were chosen by distributing 186 questionnaires to final grade students. Based on the result, criteria and subcriteria used were tuition fee, scholarship, infrastructure (library, classroom, laboratory, transportation, teaching staff), curriculum, quality (accreditation, study period, achievement), reputation, and international collaboration. According to these criteria and sub-criteria, a DSS was built to help students determine their major and higher education institution according to their preferences. The algorithm used was AHP, which was then built with Borland Delphi. Context Diagram, Data Flow Diagram (DFD), and Entity Relationship Diagram (ERD) were made as a guide to design the DSS. This DSS was tested using black box test, beta test and compatibility test with manual calculations. The black box test showed that the DSS has performed the functions according to the design. Later, the beta test resulted in a correctness score of 20.4, reliability of 16.8, usability of 25.5, which means they were in the very good category and integrity of 3.4, which means good. Meanwhile, based on manual calculations, the DSS provides output in accordance with the results of manual calculations. Finaly, he DSS was proven to be used as a decision-making tool in determining the major and higher education institution for students
Canine phaeochromocytoma: a guide to diagnosis and treatment
Authors: van den Berg Marit F , Galac Sara
Published: January 2024

Phaeochromocytomas are neuroendocrine tumours arising from chromaffin cells of the adrenal medulla. Clinical signs are primarily associated with excessive catecholamine secretion and, to a lesser extent, with the space-occupying or invasive nature of the tumour. The diagnosis of phaeochromocytoma relies on clinical suspicion, biochemical testing, diagnostic imaging and histopathology. Biochemical testing mainly depends on the measurement of levels of plasma or urinary metanephrines, with normetanephrine demonstrating superior diagnostic performance compared to metanephrine. Adrenalectomy is the treatment of choice, but may not be possible in cases with extensive local invasion, concurrent disorders or distant metastasis. Contrast-enhanced computed tomography is recommended for surgical planning and metastasis screening. Vascular invasion is frequently observed, yet surgery remains a viable option in many cases. Recent studies question the necessity of alpha-blockade before surgery, and randomised controlled clinical trials are necessary to evaluate this. Long-term survival is often seen in dogs that survive the perioperative period. For patients in which surgery is not deemed feasible, medical treatment with tyrosine-kinase inhibitors may be considered. Given the current scarcity of effective medical treatment, there is an urgent need to identify novel therapeutic options. This review provides recommendations on the diagnosis and management of canine phaeochromocytoma.
Optimization of HPMC-Based Oral Fast Dissolving Film of Cetirizine Dihydrochloride
Authors:   School of Pharmaceutical Sciences, University of Phayao, Phayao 56000, Thailand, Saepang Kamchai ,   Research Group in Herbal and Development of Formulation and Delivery Systems for Elderly Adults and Cancer Treatment, School of Pharmaceutical Sciences, University of Phayao,  Phayao 56000, Thailand, Pitaksuteepong Tasana ,   Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand, Buranrat Benjaporn ,   Research Group in Herbal and Development of Formulation and Delivery Systems for Elderly Adults and Cancer Treatment, School of Pharmaceutical Sciences, University of Phayao,  Phayao 56000, Thailand,   Faculty of Medicine, Mahasarakham University, Maha Sarakham 44000, Thailand, Boontha Supavadee ,   School of Pharmaceutical Sciences, University of Phayao, Phayao 56000, Thailand,   Research Group in Herbal and Development of Formulation and Delivery Systems for Elderly Adults and Cancer Treatment, School of Pharmaceutical Sciences, University of Phayao,  Phayao 56000, Thailand
Published: January 2024

There are challenges involved in improving the convenience of cetirizine dihydrochloride (CTZ) administration for geriatric and pediatric patients with allergic asthma. Due to the ease of swallowing, oral fast-dissolving films (OFDFs) have been identified as a potential solution. This study aimed to prepare hydroxypropyl methylcellulose (HPMC)-based OFDFs of CTZ using the solvent casting method. Film compositions, including the amounts of HPMC and glycerin, were optimized using a face-centered central composite design based on film thickness, folding endurance (FE), and disintegration time (DT). Nine prepared films were found to be transparent and clear in appearance, demonstrating the homogeneity of the films. The weights and thicknesses of all films were in the ranges of 57-109 mg and 22 - 40 µm. The FE of the prepared films was determined to be 42-156, 30-124, and 17-70 times for 3%, 4%, and 5% (w/w) HPMC-based films, respectively. The DT of the films ranged from 99 ± 13 to 478 ± 21 s as their compositions were altered in terms of the HPMC contents and the amount of glycerin. The film fabricated from 3 % (w/w) HPMC and 10% (w/w polymer mass) glycerin (F3) was identified as optimal due to achieving the highest FE and the least DT. Moreover, regression analysis demonstrated a significant effect of the HPMC and glycerin amounts on the film properties. After adding CTZ in F3 (the optimized film), the CTZ content in the films was 0.84 ± 0.14 mg/cm2. The optimized film could be evaluated further for drug release and drug permeation. Keywords: Cetirizine dihydrochloride, Film former, Folding endurance, HPMC-based film, Plasticizer
Congestive ischemic colitis successfully treated with anti-inflammatory therapy: A case report
Authors: Lee Geon Woo , Park Su Bum
Published: January 2024

BACKGROUND

Congestive ischemic colitis is a rare subtype of ischemic colitis with an unknown pathophysiology. Excluding conservative management, such as fasting, no established treatment exists; therefore, surgical intervention should be considered in some cases if symptoms worsen. Current literature suggests that anti-inflammatory agents may effectively treat congestive ischemic colitis.

CASE SUMMARY

We present the case of a 68-year-old female patient who underwent laparoscopic left hemicolectomy for transverse colon cancer 3 years ago. Postoperatively, follow-up included an annual colonoscopy and abdominal computed tomography (CT) at a local clinic. However, progressive erythema and edema of the sigmoid colon were observed 1 year postoperatively. Upon admission to our hospital, she complained of abdominal pain and diarrhea. Abdominal CT showed thickening of the sigmoid colon walls, and colonoscopy revealed erythema, edema, and multiple ulcers with exudate in the sigmoid colon. CT angiography showed engorgement of the sigmoid vasa recta without any vascular abnormalities. The diagnosis was congestive ischemic colitis, and we treated the patient with anti-inflammatory agents. After 2 mo of glucocorticoid therapy (20 mg once daily) and 7 mo of 5-aminosalicylate therapy (1 g twice daily), the ulcers completely healed. She has not experienced any recurrence for 2 years.

CONCLUSION

Anti-inflammatory therapy, specifically glucocorticoids and 5-aminosalicylate, has demonstrated promising efficacy and introduces potential novel treatment options for congestive ischemic colitis.
Lung imaging characteristics in a patient infected with Elizabethkingia miricola following cerebral hemorrhage surgery: A case report
Authors: Qi Ping-Qiang , Zeng Yi-Jun , Peng Wei , Kuai Juan
Published: January 2024

BACKGROUND

Elizabethkingia miricola is a non-fermenting gram-negative bacterium, which was first isolated from the condensate of the Russian peace space station in 2003. Most studies on this bacterium have been carried out in the laboratory, and clinical case studies are rare. To date, a total of 6 clinical cases have been reported worldwide.

CASE SUMMARY

We present the first case of postoperative pulmonary infection in a patient with intracerebral hemorrhage due to Elizabethkingia miricola . The imaging characteristics of pulmonary infection were identified and the formulation and selection of the clinical treatment plan for this patient are discussed.

CONCLUSION

Elizabethkingia miricola infection is rare. When pulmonary infection occurs, computed tomography imaging may show diffuse distribution of a ground glass density shadow in both lungs, the air containing bronchial sign in local areas, thickening of bronchial vascular bundle, and pleural effusion.
Gastric IgG4-related disease mimicking a gastrointestinal stromal tumor in a child: A case report
Authors: Lin Hsin-Chia Angela , Lee Kam-Fai , Huang Tzu Hao
Published: January 2024

BACKGROUND

Gastric IgG4-related disease (IgG4-RD) is rarely encountered in clinical practice, and especially more so among pediatric patients. To our knowledge, this is the first report of IgG4-RD presenting as a calcifying gastric mass in a child. We describe how this entity was difficult to differentiate from a gastrointestinal stromal tumor (GIST) imaging-based approaches. Therefore, this case highlights the importance of considering IgG4-RD in the differential diagnosis of gastric tumor before performing surgical resection, especially to distinguish it from malignancy to avoid unnecessary surgery.

CASE SUMMARY

The patient suffered from epigastric pain for several days. Panendoscopy and computed tomography scan revealed a submucosal tumor. Differential diagnoses included GIST, leiomyoma, teratoma, and mucinous adenocarcinoma. However, laparoscopic proximal gastrectomy allowed for the definitive diagnosis of IgG4-related stomach disease.

CONCLUSION

We emphasize the importance of considering IgG4-RD in the differential diagnosis of gastric submucosal tumors before performing surgical resection.
Intestinal malrotation complicated with gastric cancer: A case report
Authors: Jia Xiang-Hao , Kong Shuai , Gao Xin-Xin , Cong Bi-Cong , Zheng Chun-Ning
Published: January 2024

BACKGROUND

Intestinal malrotation is a congenital defect of embryonic development caused by various teratogenic factors. In this condition, the intestinal tube, along with the superior mesenteric artery serving as the axis for the counterclockwise movement, is incomplete or abnormally rotated due to incomplete attachment of the mesentery and abnormal intestinal tube position. Such a case is usually asymptomatic and thus difficult to detect. Therefore, similar variant malformations are only found during an operation required for other abdominal diseases.

CASE SUMMARY

An elderly male patient was admitted to the hospital due to gastric cancer. An abdominal computed tomography (CT) scan with contrast revealed that the ascending and descending colon were parallel on the right side of the abdominal cavity, while the sigmoid colon extended into the right iliac fossa, allowing the diagnosis of congenital midgut malrotation. Following thorough preoperative preparation, the patient underwent laparoscopic radical gastrectomy to treat his gastric cancer. Intraoperatively, an exploration of the abdominal cavity uncovered the absence of the transverse colon. The distal colon at the hepatic flexure, along with the ascending colon, extended into the right iliac fossa, where it continued as the sigmoid colon. As planned, the laparoscopic radical gastrectomy was performed, and the patient was discharged from the hospital 7 d after the surgery.

CONCLUSION

Asymptomatic intestinal malrotation is best detected by CT, requiring no treatment but possibly interfering with the treatment of other diseases.
Natural history of asymptomatic gallbladder stones in clinic without beds: A long-term prognosis over 10 years
Authors: Sakai Yuji , Tsuyuguchi Toshio , Ohyama Hiroshi , Kumagai Junichiro , Kaiho Takashi , Ohtsuka Masayuki , Kato Naoya , Sakai Tadao
Published: January 2024

BACKGROUND

Several studies have explored the long-term prognosis of patients with asymptomatic gallbladder stones. These reports were primarily conducted in facilities equipped with beds for addressing symptomatic cases.

AIM

To report the long-term prognosis of patients with asymptomatic gallbladder stones in clinics without bed facilities.

METHODS

We investigated the prognoses of 237 patients diagnosed with asymptomatic gallbladder stones in clinics without beds between March 2010 and October 2022. When symptoms developed, patients were transferred to hospitals where appropriate treatment was possible. We investigated the asymptomatic and survival periods during the follow-up.

RESULTS

Among the 237 patients, 214 (90.3%) remained asymptomatic, with a mean asymptomatic period of 3898.9279 ± 46.871 d (50-4111 d, 10.7 years on average). Biliary complications developed in 23 patients (9.7%), with a mean survival period of 4010.0285 ± 31.2788 d (53-4112 d, 10.9 years on average). No patient died of biliary complications.

CONCLUSION

The long-term prognosis of asymptomatic gallbladder stones in clinics without beds was favorable. When the condition became symptomatic, the patients were transferred to hospitals with beds that could address it; thus, no deaths related to biliary complications were reported. This finding suggests that follow-up care in clinics without beds is possible.
Efficacy and safety of Nafamostat mesylate in patients with end-stage renal failure
Authors: Liu Kun , Li Zhen-Hua
Published: January 2024

BACKGROUND

Recent studies on dialysis anticoagulation therapy in patients with renal failure have shown that Nafamostat mesylate, a broad-spectrum potent serine protease inhibitor, has strong anticoagulation and anti-fiber activity.

AIM

To evaluate the efficacy and safety of Nafamostat mesylate in patients with end-stage renal failure.

METHODS

Seventy-five patients with end-stage renal failure who received hemodialysis at our hospital between January 2020 and August 2021 were selected and divided into the observation group (Nafamostat mesylate for injection, n = 33) and control group (heparin sodium injection, n = 32). General patient data, indicators of clinical efficacy, dialyzer hemocoagulation parameters, coagulation function indices, and hemoglobin concentration and platelet count before and after treatment, and the occurrence of adverse reactions after treatment were compared between the two groups.

RESULTS

The two groups showed no significant differences in general patient data (P > 0.05). The post-treatment effectiveness rate in the control group was lower than that in the observation group (P < 0.05). The two groups showed no significant difference in the number of patients in grade I (P > 0.05), while the number of patients in grade 0 was lower in the control group, and the number of patients in grades II and III was higher in the control group (P < 0.05). The post-treatment prothrombin time, activated partial thromboplastin time, thrombin time, and international normalized ratio values in the control group were higher than those in the observation group, while the fibrinogen level in the control group was lower than that in the observation group (P < 0.05). The two groups showed no significant difference in the platelet count and hemoglobin level before and after treatment (P > 0.05). The total number of post-treatment adverse reactions in the observation group was lower than that in the control group (P < 0.05).

CONCLUSION

Treatment of patients showing end-stage renal failure with Nafamostat mesylate can significantly improve therapeutic efficacy and has high safety and clinical value.
Nursing effect of narrative nursing intervention on postoperative patients with severe lung cancer
Authors: Wen Bin , Liu Ying , Min Xiao-Xia , Wang An-Qi
Published: January 2024

BACKGROUND

Lung cancer is a common disease with high mortality, and psychological support is very important in the diagnosis and treatment of postoperative patients with cancer pain.

AIM

To explore the application effect of the narrative nursing method in postoperative lung cancer patients in the intensive care unit.

METHODS

A total of 120 patients diagnosed with lung cancer and experiencing cancer-related pain were randomly allocated into two groups: an observation group and a control group, each consisting of 60 cases. The control group was given routine analgesic and psychological care, while the research group applied the five-step narrative nursing method based on routine care, comparing the visual analogue scale scores, sleep status, anxiety and depression status, and quality of life of the two groups of patients before and after the intervention.

RESULTS

The pain scores, anxiety scores, and depression scores of the study group were lower than those of the control group after the intervention using the narrative nursing method, and the difference was statistically significant (P < 0.05).

CONCLUSION

Using narrative nursing methods to intervene in patients with lung cancer combined with cancerous pain can help patients to correctly recognize their disease, adjust their mentality, establish confidence, alleviate patients' subjective pain feelings, and improve their adverse emotions.
Honeymoon phase in type 1 diabetes mellitus: A window of opportunity for diabetes reversal?
Authors: Mittal Madhukar , Porchezhian Pradakshna , Kapoor Nitin
Published: January 2024

The knowledge of the pathogenesis of type 1 diabetes mellitus (T1DM) continues to rapidly evolve. The natural course of the disease can be described in four clinical stages based on the autoimmune markers and glycemic status. Not all individuals of T1DM progress in that specific sequence. We hereby present a case of T1DM with a classical third phase (honeymoon phase) and discuss the intricacies of this interesting phase along with a possible future promise of “cure” with the use of immunotherapies. We now know that the course of T1DM may not be in only one direction towards further progression; rather the disease may have a waxing and waning course with even reversal of type 1 diabetes concept being discussed. The third phase popularly called the “honeymoon phase”, is of special interest as this phase is complex in its pathogenesis. The honeymoon phase of T1DM seems to provide the best window of opportunity for using targeted therapies using various immunomodulatory agents leading to the possibility of achieving the elusive “diabetes reversal” in T1DM. Identifying this phase is therefore the key, with a lot of varying criteria having been proposed.