bluuebunny/crossref_metadata_2025 huggingface dataset:
An Overview on the Clinical Development of Tau-Based Therapeutics
Authors: Medina Miguel
Published: April 2018

Tauopathies such as Alzheimer’s disease (AD), frontotemporal lobar degeneration, or progressive supranuclear palsy constitute a group of brain disorders defined by neurodegeneration and the presence of tau aggregates in the affected brains regions. Tau is a microtubule-associated protein that accumulates in the cytosol under pathological conditions, steering the formation of aggregates or inclusions thought to be involved in the degeneration and neuronal death associated with these diseases. Despite a substantial and unmet medical need for novel, more effective disease-modifying therapies for the treatment of AD and tauopathies, the last couple of decades have seen numerous drug development undertakings primarily focused on β-amyloid, with disappointing results to date. On the other hand, tau-focused approaches have not received much attention until recently, notwithstanding that the presence of extensive tau pathology is fundamental for the disease and tau pathology shows a better correlation with impaired cognitive function than with amyloid pathology in AD patients. The last few years have brought us advances in our comprehension of tau biological functions beyond its well-established role as a microtubule-associated protein, unveiling novel physiological tau functions that may also be involved in pathogenesis and thus provide novel targets for therapeutic intervention. This review describes several emerging, encouraging therapeutic approaches aimed at tackling the underlying causes of tau pathology in AD and other tauopathies that have recently reached the clinical development stage.
Auction-Based Cloud Service Pricing and Penalty with Availability on Demand
Authors: Wu Xiaohong , Han Jingti
Published: April 2018

Availability is one of the main concerns of cloud users, and cloud providers always try to provide higher availability to improve user satisfaction. However, higher availability results in higher provider costs and lower social welfare. In this paper, taking into account both the users’ valuation and desired availability, we design resource allocation, pricing and penalty mechanisms with availability on demand. Considering two scenarios: public availability in which the desired availabilities of all users are public information, and private availability in which the desired availabilities are private information of users, and, analyzing the possible behaviours of users, we design a truthful deterministic mechanism with 2-approximation in public availability scenario and a universal truthful mechanism with

1

1
+
γ

approximation in private availability scenario, where

γ

is the backup ratio of resources with the highest availability. The experiment results show that our mechanisms significantly improve the social welfare compared to the mechanism without considering availability demand of users.
Simultaneous Ultra-Fast Imaging and Neutron Emission from a Compact Dense Plasma Focus Fusion Device
Authors: Majernik Nathan , Pree Seth , Sakai Yusuke , Naranjo Brian , Putterman Seth , Rosenzweig James
Published: April 2018

Recently, there has been intense interest in small dense plasma focus (DPF) devices for use as pulsed neutron and X-ray sources. Although DPFs have been studied for decades and scaling laws for neutron yield versus system discharge current and energy have been established (Milanese, M. et al., Eur. Phys. J. D 2003, 27, 77–81), there are notable deviations at low energies due to contributions from both thermonuclear and beam-target interactions (Schmidt, A. et al., Phys. Rev. Lett. 2012, 109, 1–4). For low energy DPFs (100 s of Joules), other empirical scaling laws have been found (Bures, B.L. et al., Phys. Plasmas 2012, 112702, 1–9). Although theoretical mechanisms to explain this change have been proposed, the cause of this reduced efficiency is not well understood. A new apparatus with advanced diagnostic capabilities allows us to probe this regime, including variants in which a piston gas is employed. Several complementary diagnostics of the pinch dynamics and resulting X-ray neutron production are employed to understand the underlying mechanisms involved. This apparatus is unique in its employment of a 50 fs laser-based shadowgraphy system that possesses unprecedented spatio-temporal resolution.
Near-Infrared Spectroscopic Method for Monitoring Water Content in Epoxy Resins and Fiber-Reinforced Composites
Authors: Krauklis Andrey , Gagani Abedin , Echtermeyer Andreas
Published: April 2018

Monitoring water content and predicting the water-induced drop in strength of fiber-reinforced composites are of great importance for the oil and gas and marine industries. Fourier transform infrared (FTIR) spectroscopic methods are broadly available and often used for process and quality control in industrial applications. A benefit of using such spectroscopic methods over the conventional gravimetric analysis is the possibility to deduce the mass of an absolutely dry material and subsequently the true water content, which is an important indicator of water content-dependent properties. The objective of this study is to develop an efficient and detailed method for estimating the water content in epoxy resins and fiber-reinforced composites. In this study, Fourier transform near-infrared (FT-NIR) spectroscopy was applied to measure the water content of amine-epoxy neat resin. The method was developed and successfully extended to glass fiber-reinforced composite materials. Based on extensive measurements of neat resin and composite samples of varying water content and thickness, regression was performed, and the quantitative absorbance dependence on water content in the material was established. The mass of an absolutely dry resin was identified, and the true water content was obtained. The method was related to the Beer–Lambert law and explained in such terms. A detailed spectroscopic method for measuring water content in resins and fiber-reinforced composites was developed and described.
Effect of Atmospheric Corrosion on the Mechanical Properties of SAE 1020 Structural Steel
Authors: Martínez Carola , Briones Francisco , Villarroel María , Vera Rosa
Published: April 2018

Resistance to atmospheric corrosion in different environments located in Chile and the corrosion’s effect on the mechanical properties of SAE 1020 steel were studied. Atmospheric corrosivity categories at each station under study were determined. These categories were C2, for Laja; C3 and C4, for the Arica and Antarctic stations, respectively; and the most aggressive, C5 and higher at Quintero. These specific environments significantly influenced the mechanical responses of steel exposed for 36 months. Rupture elongation, the modulus of toughness, ultimate tensile strength, and hardness of the material all decreased as a function of environmental atmospheric aggressiveness. Lowered ductility is the result of the increased corrosion rate due to the high deposition of chlorides. This is due to the morphology of material degradation, which consequently occurs as pores, microstrains, and other defects that promote early rupture of the steel.
Improved Dehydrogenation Performance of Li-B-N-H by Doped NiO
Authors: Wu Yipeng , Xu Fen , Sun Lixian , Xia Yongpeng , Li Peng , Chen Jun , Yang Xia , Yu Fang , Zhang Huanzhi , Chu Hailiang , Zou Yongjin
Published: April 2018

In order to improve the dehydrogenation properties of the Li-B-N-H system, a flower-like NiO was successfully synthesized using the hydrothermal method. The effect of the NiO on the dehydrogenation properties of the LiBH4-2LiNH2 system was studied. The results showed that the dehydrogenation properties of the LiBH4-2LiMH2 system were significantly enhanced by doping with NiO. The composite doped with 5 wt. % NiO exhibited optimal hydrogen storage properties. It released about 10.5 wt. % hydrogen below 300 °C, and the onset dehydrogenation temperature was only 90 °C, 110 °C lower than that of LiBH4-2LiNH2. The isothermal dehydrogenation experiment indicated that the LiBH4-2LiNH2-5 wt. % NiO composite released 8.8 wt. % hydrogen within 15 min at 150 °C. Structural analysis revealed that the as-prepared NiO was reduced to metallic Ni, which worked as an active catalytic species in the remainder of the dehydrogenation process. The Mass Spectrometer (MS) analyses showed that the doped NiO inhibited the content of NH3 released in the process of the dehydrogenation of LiBH4-2LiNH2-NiO.
Comprehensive Die Shear Test of Silicon Packages Bonded by Thermocompression of Al Layers with Thin Sn Capping or Insertions
Authors: Satoh Shiro , Fukushi Hideyuki , Esashi Masayoshi , Tanaka Shuji
Published: April 2018

Thermocompression bonding for wafer-level hermetic packaging was demonstrated at the lowest temperature of 370 to 390 °C ever reported using Al films with thin Sn capping or insertions as bonding layer. For shrinking the chip size of MEMS (micro electro mechanical systems), a smaller size of wafer-level packaging and MEMS–ASIC (application specific integrated circuit) integration are of great importance. Metal-based bonding under the temperature of CMOS (complementary metal-oxide-semiconductor) backend process is a key technology, and Al is one of the best candidates for bonding metal in terms of CMOS compatibility. In this study, after the thermocompression bonding of two substrates, the shear fracture strength of dies was measured by a bonding tester, and the shear-fractured surfaces were observed by SEM (scanning electron microscope), EDX (energy dispersive X-ray spectrometry), and a surface profiler to clarify where the shear fracture took place. We confirmed two kinds of fracture mode. One mode is Si bulk fracture mode, where the die shear strength is 41.6 to 209 MPa, proportionally depending on the area of Si fracture. The other mode is bonding interface fracture mode, where the die shear strength is 32.8 to 97.4 MPa. Regardless of the fracture modes, the minimum die shear strength is practical for wafer-level MEMS packaging.
Microfabricated Vapor Cells with Reflective Sidewalls for Chip Scale Atomic Sensors
Authors: Han Runqi , You Zheng , Zhang Fan , Xue Hongbo , Ruan Yong
Published: April 2018

We investigate the architecture of microfabricated vapor cells with reflective sidewalls for applications in chip scale atomic sensors. The optical configuration in operation is suitable for both one-beam and two-beam (pump & probe) schemes. In the miniaturized vapor cells, the laser beam is reflected twice by the aluminum reflectors on the wet etched 54.7° sidewalls to prolong the optical length significantly, thus resulting in a return reflectance that is three times that of bare silicon sidewalls. To avoid limitations faced in the fabrication process, a simpler, more universal and less constrained fabrication process of microfabricated vapor cells for chip scale atomic sensors with uncompromised performance is implemented, which also decreases the fabrication costs and procedures. Characterization measurements show that with effective sidewall reflectors, mm3 level volume and feasible hermeticity, the elongated miniature vapor cells demonstrate a linear absorption contrast improvement by 10 times over the conventional micro-electro-mechanical system (MEMS) vapor cells at ~50 °C in the rubidium D1 absorption spectroscopy experiments. At the operating temperature of ~90 °C for chip scale atomic sensors, a 50% linear absorption contrast enhancement is obtained with the reflective cell architecture. This leads to a potential improvement in the clock stability and magnetometer sensitivity. Besides, the coherent population trapping spectroscopy is applied to characterize the microfabricated vacuum cells with 46.3 kHz linewidth in the through cell configuration, demonstrating the effectiveness in chip scale atomic sensors.
Mechanical Response of MEMS Inductor with Auxiliary Pillar under High-g Shock
Authors: Xu Lixin , Li Yiyuan , Li Jianhua , Lu Chongying
Published: April 2018

Micro-electromechanical system (MEMS) suspended inductors have excellent radio-frequency (RF) performance, but poor mechanical properties. To improve their reliability, auxiliary pillars have been used. However, few studies have been carried out on the response of a suspended inductor with auxiliary pillars under high mechanical shock. In this paper, a theoretical method is proposed that combines a single-degree-of-freedom (SDOF) model and a method for solving statically indeterminate structures. The calculated results obtained by this proposed method were verified by finite-element analysis (ANSYS). The calculated results obtained by the proposed method were found to agree well with the results of ANSYS simulation. Finally, this method was extended to a suspended inductor with double auxiliary pillars. The method proposed in this paper provides a theoretical reference for mechanical performance evaluation and reliability optimization design for MEMS suspended inductors with auxiliary pillars.
Developing Effective Separation of Feldspar and Quartz While Recycling Tailwater by HF Pretreatment
Authors: Wang Weiqing , Cong Jinyao , Deng Jie , Weng Xiaoqing , Lin Yiming , Huang Yang , Peng Tiefeng
Published: April 2018

The effect of hydrofluoric acid (HF) pretreatment on flotation of feldspar and quartz using dodecylamine (DDA) as collector was investigated by micro-flotation, zeta potential, pyrene fluorescence spectroscopy, attenuated total reflection flourier transformed infrared spectroscopy (ATR-FTIR), scanning electron microscope (SEM), X-ray photoelectron spectroscopy (XPS) and bench scale flotation. The micro-flotation tests revealed that there was little difference in the flotation of feldspar and quartz at pH 2, using H2SO4 as pH regulator. After HF pretreatment, the floatability of feldspar significantly increased while the floatability of quartz showed no change. HF pretreatment resulted in leaching of SiO2 and enrichment of Na, K and Al on the feldspar surface. Consequently, the negative surface charge of feldspar increased at pH 2, which allowed for the flotation separation of the feasible minerals. This took place via an increased electrostatic adsorption between DDA and Na, K, Al on the feldspar surface, which effectively increased its hydrophobicity and as a result, improved the floatability of feldspar. An alternative process which exhibited effective separation of quartz and feldspar while recycling the tailwater from the flotation was proposed.
The Influencing Mechanisms of Sodium Hexametaphosphate on Chalcopyrite Flotation in the Presence of MgCl2 and CaCl2
Authors: Li Wanqing , Li Yubiao , Xiao Qing , Wei Zhenlun , Song Shaoxian
Published: April 2018

Sea water has been used in flotation plants, showing a promising way to save fresh water usage. Previous studies indicated that divalent salts in sea water played negative roles in chalcopyrite flotation, but not much work have been conducted to understand the eliminating mechanisms. This study systematically investigated the effects of divalent cations of Ca2+ and Mg2+ on natural flotability of chalcopyrite in the absence of collectors and frothers. The reduced recovery was mainly due to the adsorption of Mg and Ca hydroxyl complexes and precipitation on chalcopyrite surfaces, giving rise to a less hydrophobic surface. The addition of sodium hexametaphosphate (SHMP), however, significantly improved chalcopyrite recovery. Species calculation, contact angle, zeta potential, FTIR and XPS analyses were conducted to understand the influencing mechanisms of divalent ions and the beneficial effects of SHMP on chalcopyrite recovery. The primary mechanism was that SHMP prevented the adsorption of positively charged Mg and Ca compounds or precipitation with hydrophilic properties such as Mg(OH)2 on chalcopyrite surfaces, confirmed by the Derjguin-Landau-Verwey-Overbeek (DLVO) theory. Secondly, SHMP reacted with Mg2+ and Ca2+ to form dissolvable complexes, thereby declining the formation of insoluble Mg2+ and Ca2+ compounds or precipitation.
In Vitro Dermal Safety Assessment of Silver Nanowires after Acute Exposure: Tissue vs. Cell Models
Authors: Lehmann Sylvia , Gilbert Benjamin , Maffeis Thierry , Grichine Alexei , Pignot-Paintrand Isabelle , Clavaguera Simon , Rachidi Walid , Seve Michel , Charlet Laurent
Published: April 2018

Silver nanowires (AgNW) are attractive materials that are anticipated to be incorporated into numerous consumer products such as textiles, touchscreen display, and medical devices that could be in direct contact with skin. There are very few studies on the cellular toxicity of AgNW and no studies that have specifically evaluated the potential toxicity from dermal exposure. To address this question, we investigated the dermal toxicity after acute exposure of polymer-coated AgNW with two sizes using two models, human primary keratinocytes and human reconstructed epidermis. In keratinocytes, AgNW are rapidly and massively internalized inside cells leading to dose-dependent cytotoxicity that was not due to Ag+ release. Analysing our data with different dose metrics, we propose that the number of NW is the most appropriate dose-metric for studies of AgNW toxicity. In reconstructed epidermis, the results of a standard in vitro skin irritation assay classified AgNW as non-irritant to skin and we found no evidence of penetration into the deeper layer of the epidermis. The findings show that healthy and intact epidermis provides an effective barrier for AgNW, although the study does not address potential transport through follicles or injured skin. The combined cell and tissue model approach used here is likely to provide an important methodology for assessing the risks for skin exposure to AgNW from consumer products.
Associations of Mediterranean Diet and a Posteriori Derived Dietary Patterns with Breast and Lung Cancer Risk: A Case-Control Study
Authors: Krusinska Beata , Hawrysz Iwona , Wadolowska Lidia , Slowinska Malgorzata , Biernacki Maciej , Czerwinska Anna , Golota Janusz
Published: April 2018

Lung cancer in men and breast cancer in women are the most commonly diagnosed cancers in Poland and worldwide. Results of studies involving dietary patterns (DPs) and breast or lung cancer risk in European countries outside the Mediterranean Sea region are limited and inconclusive. This study aimed to develop a ‘Polish-adapted Mediterranean Diet’ (‘Polish-aMED’) score, and then study the associations between the ‘Polish-aMED’ score and a posteriori-derived dietary patterns with breast or lung cancer risk in adult Poles. This pooled analysis of two case-control studies involved 560 subjects (280 men, 280 women) aged 40–75 years from Northeastern Poland. Diagnoses of breast cancer in 140 women and lung cancer in 140 men were found. The food frequency consumption of 21 selected food groups was collected using a 62-item Food Frequency Questionnaire (FFQ)-6. The ‘Polish-adapted Mediterranean Diet’ score which included eight items—vegetables, fruit, whole grain, fish, legumes, nuts and seeds—as well as the ratio of vegetable oils to animal fat and red and processed meat was developed (range: 0–8 points). Three DPs were identified in a Principal Component Analysis: ‘Prudent’, ‘Non-healthy’, ‘Dressings and sweetened-low-fat dairy’. In a multiple logistic regression analysis, two models were created: crude, and adjusted for age, sex, type of cancer, Body Mass Index (BMI), socioeconomic status (SES) index, overall physical activity, smoking status and alcohol abuse. The risk of breast or lung cancer was lower in the average (3–5 points) and high (6–8 points) levels of the ‘Polish-aMED’ score compared to the low (0–2 points) level by 51% (odds ratio (OR): 0.49; 95% confidence interval (Cl): 0.30–0.80; p < 0.01; adjusted) and 63% (OR: 0.37; 95% Cl: 0.21–0.64; p < 0.001; adjusted), respectively. In the middle and upper tertiles compared to the bottom tertile of the ‘Prudent’ DP, the risk of cancer was lower by 38–43% (crude) but was not significant after adjustment for confounders. In the upper compared to the bottom tertile of the ‘Non-healthy’ DP, the risk of cancer was higher by 65% (OR: 1.65; 95% Cl: 1.05–2.59; p < 0.05; adjusted). In conclusion, the Polish adaptation of the Mediterranean diet could be considered for adults living in non-Mediterranean countries for the prevention of the breast or lung cancers. Future studies should explore the role of a traditional Mediterranean diet fitted to local dietary patterns of non-Mediterranean Europeans in cancer prevention.
Novel Nano-Liposome Formulation for Dry Eyes with Components Similar to the Preocular Tear Film
Authors: Vicario-de-la-Torre Marta , Caballo-González María , Vico Eva , Morales-Fernández Laura , Arriola-Villalobos Pedro , De las Heras Beatriz , Benítez-del-Castillo José , Guzmán Manuel , Millar Thomas , Herrero-Vanrell Rocío , Molina-Martínez Irene
Published: April 2018

Dry eye is commonly treated with artificial tears; however, developing artificial tears similar to natural tears is difficult due to the complex nature of tears. We characterized and evaluated a novel artificial tear formulation with components similar to the lipid and aqueous constituents of natural tears. Nano-liposomes, composed in part of phosphatidylcholine, were dispersed in an aqueous solution of bioadhesive sodium hyaluronate. Liposome size, zeta potential, and physicochemical properties of the fresh and stored (4 °C) liposomal formulation were analyzed. In vitro tolerance was tested using human corneal and conjunctival cell lines by exposures of 15 min to 4 h. The tolerance of the liposomal formulation was evaluated in animals (rabbits). The average liposome size was 186.3 ± 7.0 nm, and the zeta potential was negative. The osmolarity of the formulation was 198.6 ± 1.7 mOsm, with a surface tension of 36.5 ± 0.4 mN/m and viscosity of 3.05 ± 0.02 mPa·s. Viability values in the human corneal and conjunctival cell lines were always >80%, even after liposomal formulation storage for 8 weeks. Discomfort and clinical signs after instillation in rabbit eyes were absent. The new formulation, based on phosphatidylcholine-liposomes dispersed in sodium hyaluronate has suitable components and characteristics, including high in vitro cell viability and good in vivo tolerance, to serve as a tear substitute.
Aliphatic Polyester Nanofibers Functionalized with Cyclodextrins and Cyclodextrin-Guest Inclusion Complexes
Authors: Narayanan Ganesh , Shen Jialong , Boy Ramiz , Gupta Bhupender , Tonelli Alan
Published: April 2018

The fabrication of nanofibers by electrospinning has gained popularity in the past two decades; however, only in this decade, have polymeric nanofibers been functionalized using cyclodextrins (CDs) or their inclusion complexes (ICs). By combining electrospinning of polymers with free CDs, nanofibers can be fabricated that are capable of capturing small molecules, such as wound odors or environmental toxins in water and air. Likewise, combining polymers with cyclodextrin-inclusion complexes (CD-ICs), has shown promise in enhancing or controlling the delivery of small molecule guests, by minor tweaking in the technique utilized in fabricating these nanofibers, for example, by forming core–shell or multilayered structures and conventional electrospinning, for controlled and rapid delivery, respectively. In addition to small molecule delivery, the thermomechanical properties of the polymers can be significantly improved, as our group has shown recently, by adding non-stoichiometric inclusion complexes to the polymeric nanofibers. We recently reported and thoroughly characterized the fabrication of polypseudorotaxane (PpR) nanofibers without a polymeric carrier. These PpR nanofibers show unusual rheological and thermomechanical properties, even when the coverage of those polymer chains is relatively sparse (~3%). A key advantage of these PpR nanofibers is the presence of relatively stable hydroxyl groups on the outer surface of the nanofibers, which can subsequently be taken advantage of for bioconjugation, making them suitable for biomedical applications. Although the number of studies in this area is limited, initial results suggest significant potential for bone tissue engineering, and with additional bioconjugation in other areas of tissue engineering. In addition, the behaviors and uses of aliphatic polyester nanofibers functionalized with CDs and CD-ICs are briefly described and summarized. Based on these observations, we attempt to draw conclusions for each of these combinations, and the relationships that exist between their presence and the functional behaviors of their nanofibers.
An Efficient Parallel Multi-Scale Segmentation Method for Remote Sensing Imagery
Authors: Gu Haiyan , Han Yanshun , Yang Yi , Li Haitao , Liu Zhengjun , Soergel Uwe , Blaschke Thomas , Cui Shiyong
Published: April 2018

Remote sensing (RS) image segmentation is an essential step in geographic object-based image analysis (GEOBIA) to ultimately derive “meaningful objects”. While many segmentation methods exist, most of them are not efficient for large data sets. Thus, the goal of this research is to develop an efficient parallel multi-scale segmentation method for RS imagery by combining graph theory and the fractal net evolution approach (FNEA). Specifically, a minimum spanning tree (MST) algorithm in graph theory is proposed to be combined with a minimum heterogeneity rule (MHR) algorithm that is used in FNEA. The MST algorithm is used for the initial segmentation while the MHR algorithm is used for object merging. An efficient implementation of the segmentation strategy is presented using data partition and the “reverse searching-forward processing” chain based on message passing interface (MPI) parallel technology. Segmentation results of the proposed method using images from multiple sensors (airborne, SPECIM AISA EAGLE II, WorldView-2, RADARSAT-2) and different selected landscapes (residential/industrial, residential/agriculture) covering four test sites indicated its efficiency in accuracy and speed. We conclude that the proposed method is applicable and efficient for the segmentation of a variety of RS imagery (airborne optical, satellite optical, SAR, high-spectral), while the accuracy is comparable with that of the FNEA method.
Suspect Outsiders or Prospective Citizens? Constructing the Immigrant/German Boundary in Germany’s Integration Courses
Authors: Williams Daniel
Published: April 2018

Most scholarship on integration and assimilation in Europe has examined laws, policies and quantitative data to understand the integration of immigrants. Fewer studies have looked at the meaning of integration for immigrants and host societies. This article helps to fill this gap in scholarship by examining the construction of immigrants and Germany in mandatory integration courses in contemporary Germany. Using ethnographic observations of integration courses and discourse analysis of curricular materials, I analyze these constructions using a boundary-construction approach, where both the content of what separates immigrants from host society members, and the brightness of the boundary are used as a basis for viewing immigrants as outsiders versus citizens. I use the terms suspect outsiders and prospective citizens to describe the nature of the immigrant/German boundary based on these constructions. The findings show that three themes—gender and family norms, democracy and rights, and religious freedom—form the content of the immigrant/German boundary. Within these themes, Germany’s civic integration courses generally construct immigrants as prospective citizens by blurring the immigrant/German boundary. The nature of the immigrant/German boundary is crucial for both the integration of immigrants and for Germany. A bright boundary that invokes the notion of immigrants as fundamentally different places the burden of integration on them to change, while a blurred boundary potentially redefines what it means to be German.
The Performance of Early-Generation Perennial Winter Cereals at 21 Sites across Four Continents
Authors: Hayes Richard , Wang Shuwen , Newell Matthew , Turner Kathryn , Larsen Jamie , Gazza Laura , Anderson James , Bell Lindsay , Cattani Douglas , Frels Katherine , Galassi Elena , Morgounov Alexey , Revell Clinton , Thapa Dhruba , Sacks Erik , Sameri Mohammad , Wade Len , Westerbergh Anna , Shamanin Vladimir , Amanov Amir , Li Guangdi
Published: April 2018

A network of 21 experiments was established across nine countries on four continents and spanning both hemispheres, to evaluate the relative performance of early generation perennial cereal material derived from wheat, rye, and barley and to inform future breeding strategies. The experimental lines were grown in replicated single rows, and first year production and phenology characteristics as well as yield and persistence for up to three years were monitored. The study showed that the existing experimental material is all relatively short-lived (≤3 years), with environments that are milder in summer and winter generally conferring greater longevity. No pedigree was superior across this diverse network of sites although better performing lines at the higher latitude sites were generally derived from Thinopyrum intermedium. By contrast, at lower latitudes the superior lines were generally derived from Th. ponticum and Th. elongatum parentage. The study observed a poor relationship between year 1 performance and productivity in later years, highlighting the need for perennial cereal material with greater longevity to underpin future experimental evaluation, and the importance for breeding programs to emphasize post-year 1 performance in their selections. Hybrid lines derived from the tetraploid durum wheat generally showed greater longevity than derivatives of hexaploid wheat, highlighting potential for greater use of Triticum turgidum in perennial wheat breeding. We advocate a model in future breeding initiatives that develops perennial cereal genotypes for specific target environments rather than a generic product for one global market. These products may include a diversity of cultivars derived from locally adapted annual and perennial parents. In this scenario the breeding program may have access to only a limited range of adapted perennial grass parents. In other situations, such as at very high latitude environments, perennial crops derived from barley or rye may have a better chance of success than those derived from wheat. In either case, development and selection of the perennial parent for adaptation to local environments would seem fundamental to success.
Hyperspectral Estimation of the Chlorophyll Content in Short-Term and Long-Term Restorations of Mangrove in Quanzhou Bay Estuary, China
Authors: Dou Zhiguo , Cui Lijuan , Li Jing , Zhu Yinuo , Gao Changjun , Pan Xu , Lei Yinru , Zhang Manyin , Zhao Xinsheng , Li Wei
Published: April 2018

The chlorophyll content can indicate the general health of vegetation, and can be estimated from hyperspectral data. The aim of this study is to estimate the chlorophyll content of mangroves at different stages of restoration in a coastal wetland in Quanzhou, China, using proximal hyperspectral remote sensing techniques. We determine the hyperspectral reflectance of leaves from two mangrove species, Kandelia candel and Aegiceras corniculatum, from short-term and long-term restoration areas with a portable spectroradiometer. We also measure the leaf chlorophyll content (SPAD value). We use partial-least-squares stepwise regression to determine the relationships between the spectral reflectance and the chlorophyll content of the leaves, and establish two models, a full-wave-band spectrum model and a red-edge position regression model, to estimate the chlorophyll content of the mangroves. The coefficients of determination for the red-edge position model and the full-wave-band model exceed 0.72 and 0.82, respectively. The inverted chlorophyll contents are estimated more accurately for the long-term restoration mangroves than for the short-term restoration mangroves. Our results indicate that hyperspectral data can be used to estimate the chlorophyll content of mangroves at different stages of restoration, and could possibly be adapted to estimate biochemical constituents in leaves.
Operational Decisions on Remanufacturing Outsourcing Involved with Corporate Environmental and Social Responsibility—A Sustainable Perspective
Authors: Yan Wei , Chai Junwu , Qian Zhifeng , Tsai Sang-Bing , Chen Hong , Xiong Yu
Published: April 2018

Due to increasing consciousness of sustainability and pressure from legislation, numerous studies and managers have sought to integrate traditional operations management with green environment and social responsibility. One such effort is remanufacturing, which has emerged as a growing topic. Although outsourcing remanufacturing operations to third-party remanufacturers (TPRs) has been well studied in the literature, the research has paid little attention to the fact that original equipment manufacturers (OEMs) have the flexibility of outsourcing to other agents but not TPRs. In practice, besides TPRs, many brand-name OEMs have outsourced remanufacturing operations to their suppliers. The question this raises is: TPR vs. supplier, which remanufacturer is better for the economic, environment and social responsibility? To understand this fundamental question, in this paper, we develop two models that allow an OEM to have potential flexibility to (1) outsource remanufacturing operations to a TPR (Model T) or (2) outsource remanufacturing operations to a supplier (Model S). Among other results, we find that, although the Model T creates more potentially sustainable economic, social, and environmental situations, this strategy is not supported by the supplier because it always leaves the supplier worse off. In order to achieve a “win-win-win” outcome that meets economic, social, and environmental requirements for all parties, a revenue-sharing contract is proposed and incorporated into Model T.
A New Framework to Evaluate Urban Design Using Urban Microclimatic Modeling in Future Climatic Conditions
Authors: Mauree Dasaraden , Coccolo Silvia , Perera Amarasinghage , Nik Vahid , Scartezzini Jean-Louis , Naboni Emanuele
Published: April 2018

Building more energy-efficient and sustainable urban areas that will both mitigate the effects of climate change and anticipate living conditions in future climate scenarios requires the development of new tools and methods that can help urban planners, architects and communities achieve this goal. In the current study, we designed a workflow that links different methodologies developed separately, to derive the energy consumption of a university school campus for the future. Three different scenarios for typical future years (2039, 2069, 2099) were run, as well as a renovation scenario (Minergie-P). We analyzed the impact of climate change on the heating and cooling demand of buildings and determined the relevance of taking into account the local climate in this particular context. The results from the simulations confirmed that in the future, there will be a constant decrease in the heating demand, while the cooling demand will substantially increase. Significantly, it was further demonstrated that when the local urban climate was taken into account, there was an even higher rise in the cooling demand, but also that a set of proposed Minergie-P renovations were not sufficient to achieve resilient buildings. We discuss the implication of this work for the simulation of building energy consumption at the neighborhood scale and the impact of future local climate on energy system design. We finally give a few perspectives regarding improved urban design and possible pathways for future urban areas.
Sustainable Supply Chain Management in Small and Medium Enterprises
Authors: Kot Sebastian
Published: April 2018

The sector of small and medium-sized enterprises (SMEs) plays a key role in the economies of all of the countries in the world. These entities constitute the basis for the development of the national and global economies. In a contemporary complex and competitive business environment, the adaptation of appropriate strategies is a particularly important effort to furthering the development of companies from the SMEs sector. In this context, the application of the concept of sustainable supply chain management (SCM) in the operation strategy of SMEs seems to be a very important function. This supply chain also covers all three aspects of sustainable development: business, environmental, and social. The purpose of this article is to present the current state of the research in sustainable development in relation to managing the supply chain of SMEs, as well as the empirical findings in this area. The results found that all of the sustainability areas were very important in the supply chain management practices of the studied SMEs, despite the imbalance described in the literature. The study also presents the most important elements in the particular sustainability areas of SCM and SMEs.
Public Value of Enforcing the PM2.5 Concentration Reduction Policy in South Korean Urban Areas
Authors: Kim Ju-Hee , Kim Hyo-Jin , Yoo Seung-Hoon
Published: April 2018

As the number of cars and the electricity produced from coal-fired generation has been increasing, PM2.5, particles smaller than 2.5 μm in diameter, has become a serious problem in South Korean urban areas. This is especially notable, given that the PM2.5 warning was issued 89 times during 2016. Because of this, the South Korean government is seeking to enforce a policy of reducing the number of PM2.5 warnings by half using various policy instruments from now until 2022. This article tries to obtain information about the public value of the enforcement. For this purpose, household willingness to pay (WTP) for the enforcement is investigated, applying the contingent valuation (CV) approach. A survey of 1000 households was carried out in South Korean urban areas. The data on the WTP were gathered using a dichotomous choice question and analyzed employing the spike model. The mean WTP estimate is obtained as KRW 5591 (USD 4.97) per household per year, which is statistically significant. The total public value expanded to the population amounts to KRW 98.9 billion (USD 87.8 million) per year. The information can be utilized in policy-making and decision-making about the reduction of the PM2.5 concentration.
Electric Road Systems: Strategic Stepping Stone on the Way towards Sustainable Freight Transport?
Authors: Schulte Jesko , Ny Henrik
Published: April 2018

Electrification of the transport sector has been pointed out as a key factor for tackling some of today’s main challenges, such as global warming, air pollution, and eco-system degradation. While numerous studies have investigated the potential of electrifying passenger transport, less focus has been on how road freight transport could be powered in a sustainable future. This study looks at Electric Road Systems (ERS) in comparison to the current diesel system. The Framework for Strategic Sustainable Development was used to assess whether ERS could be a stepping stone on the way towards sustainability. Strategic life-cycle assessment was applied, scanning each life-cycle phase for violations against basic sustainability principles. Resulting sustainability “hot spots” were quantified with traditional life-cycle assessment. The results show that, if powered by renewable energy, ERS have a potential to decrease the environmental impact of freight transport considerably. Environmental payback times of less than five years are achievable if freight traffic volumes are sufficiently high. However, some severe violations against sustainability principles were identified. Still, ERS could prove to be a valuable part of the solution, as they drastically decrease the need for large batteries with high cost and sustainability impact, thereby catalyzing electrification and the transition towards sustainable freight transport.
The System Dynamics (SD) Analysis of the Government and Power Producers’ Evolutionary Game Strategies Based on Carbon Trading (CT) Mechanism: A Case of China
Authors: Zhao Xin-gang , Zhang Yu-zhuo
Published: April 2018

Climate warming caused by carbon emissions is one of the most serious problems faced by human beings, and the carbon trading (CT) mechanism is an effective way to promote carbon emission reduction and achieve green and low-carbon development. Scholars have mainly studied the impact of CT on the energy economy system, and few scholars studied the game process and behavior strategies of government and power producers in the implementation of a CT mechanism. This paper will fill this gap. This paper firstly constructs the evolutionary game model of government and power producers based on CT, and then simulates the evolutionary process of game behavior strategies by establishing a system dynamics (SD) model, and finally studies the influence of government controllable key factors on system stability. The combination of evolutionary game and SD in our study not only clearly reveals the complex and dynamic evolution process of game models under bounded rationality, but also provides a qualitative and quantitative simulation platform for analyzing the dynamic game process between government and power producers. The results show that: (1) There is no evolutionarily stable strategy (ESS) in the game system between government and power producers under CT, and the system evolution is characterized by periodicity; (2) When the government implements dynamic subsidies or punitive measures, the mixed strategy of the game system has ESS; (3) Reducing the unit subsidy and raising the unit fine can both promote the participation of power producers in CT, but the former increases the probability of government supervision; thus, it is best to increase the fines when the government makes strategic adjustments, followed by reducing subsidies.
The Spatial Homeostasis Hypothesis
Authors: Epstein Oleg
Published: April 2018

From studies on the effects of “high dilutions” on organisms, it was found that their administration induces a delicate physiological (molecular and cellular) response. Occasionally, physiological reactions can become atypical (pathological) individual reactions. To resolve this paradox, the spatial homeostasis hypothesis has been proposed. It considers pathological processes as tools used by living systems, in order to retain their spatial integrity (symmetry), allowing them to properly reflect the geometry of the surrounding world and thus, to be a part of the evolutionary process. This article addresses an interdisciplinary subject and is aimed at natural scientists (physicists, chemists, and biologists) as well as philosophers.
Colibactin: More Than a New Bacterial Toxin
Authors: Faïs Tiphanie , Delmas Julien , Barnich Nicolas , Bonnet Richard , Dalmasso Guillaume
Published: April 2018

Cyclomodulins are bacterial toxins that interfere with the eukaryotic cell cycle. A new cyclomodulin called colibactin, which is synthetized by the pks genomic island, was discovered in 2006. Despite many efforts, colibactin has not yet been purified, and its structure remains elusive. Interestingly, the pks island is found in members of the family Enterobacteriaceae (mainly Escherichia coli and Klebsiella pneumoniae) isolated from different origins, including from intestinal microbiota, septicaemia, newborn meningitis, and urinary tract infections. Colibactin-producing bacteria induce chromosomal instability and DNA damage in eukaryotic cells, which leads to senescence of epithelial cells and apoptosis of immune cells. The pks island is mainly observed in B2 phylogroup E. coli strains, which include extra-intestinal pathogenic E. coli strains, and pks E. coli are over-represented in biopsies isolated from colorectal cancer. In addition, pks E. coli bacteria increase the number of tumours in diverse colorectal cancer mouse models. Thus, colibactin could have a major impact on human health. In the present review, we will focus on the biological effects of colibactin, the distribution of the pks island, and summarize what is currently known about its synthesis and its structure.
Heading in the Right Direction? Investigating Walkability in Galway City, Ireland
Authors: Hynes Mike , Seoighthe Eibhlín
Published: April 2018

As cities and towns worldwide strive to improve quality of life for citizens, debates centred on mobility are at the forefront of transportation policy thinking and urban design and planning. The automobile radically transformed cities, not always for the better, and the transport paradigm espoused over previous decades has primarily focussed on cars. This is still largely evident, driven by policymakers and key decisionmakers using forecasting and transportation and economic models that justify such car-centric planning. However, it is now clear that this approach of increasing automobility is unsustainable. Urban planners across the world are coming to a similar conclusion; they are better off with fewer cars, and a new vision is required, which sees people embracing active and sustainable transportation and sharing public space, information, and new innovative services to make cities more attractive and liveable. Walkability is the measure of how pleasant an area is for walking. By promoting and encouraging people to walk more, we achieve the benefits of better personal health and safer, more convivial neighbourhoods and communities. Making cities more walkable involves incorporating features into urban landscapes that make walking an agreeable experience and bringing a range of necessary and interesting destinations within walking distances of homes and workplaces. Using data from the Mobilities and Liveability in Galway project, this paper seeks a richer understanding of issues relating to existing topographies of walkability and the barriers and pressures that exist with regards to the further development of walking in the city—a healthy and pleasurable way of getting about.
Oral Vaccination with a DNA Vaccine Encoding Capsid Protein of Duck Tembusu Virus Induces Protection Immunity
Authors: Huang Juan , Shen Haoyue , Jia Renyong , Wang Mingshu , Chen Shun , Zhu Dekang , Liu Mafeng , Zhao Xinxin , Yang Qiao , Wu Ying , Liu Yunya , Zhang Ling , Yin Zhongqiong , Jing Bo , Cheng Anchun
Published: April 2018

The emergence of duck tembusu virus (DTMUV), a new member of the Flavivirus genus, has caused great economical loss in the poultry industry in China. Since the outbreak and spread of DTMUV is hard to control in a clinical setting, an efficient and low-cost oral delivery DNA vaccine SL7207 (pVAX1-C) based on the capsid protein of DTMUV was developed and evaluated in this study. The antigen capsid protein was expressed from the DNA vaccine SL7207 (pVAX1-C), both in vitro and in vivo. The humoral and cellular immune responses in vivo were observed after oral immunization with the SL7207 (pVAX1-C) DNA vaccine. High titers of the specific antibody against the capsid protein and the neutralizing antibody against the DTMUV virus were both detected after inoculation. The ducks were efficiently protected from lethal DTMUV exposure by the SL7207 (pVAX1-C) vaccine in this experiment. Taken together, we demonstrated that the capsid protein of DTMUV possesses a strong immunogenicity against the DTMUV infection. Moreover, an oral delivery of the DNA vaccine SL7207 (pVAX1-C) utilizing Salmonella SL7207 was an efficient way to protect the ducks against DTMUV infection and provides an economic and fast vaccine delivery strategy for a large scale clinical use.