bluuebunny/crossref_metadata_2025 huggingface dataset:
Psoriasis seems often underdiagnosed in patient with axial spondyloarthritis
Authors: Rondags Angelique , van Marle Laura , Horváth Barbara , Wink Freke R. , Arends Suzanne , Spoorenberg Anneke
Published: August 2023

Background

Axial spondyloarthritis (axSpA) is known to be associated with several extra-skeletal manifestations (ESM), including the inflammatory skin disease psoriasis. It is important to recognize and diagnose psoriasis timely in axSpA in order to provide optimal treatment and outcome for both axSpA and psoriasis.

Methods

In this observational study, all patients from the Dutch Groningen Leeuwarden Axial Spondyloarthritis (GLAS) cohort included before June 2016 were sent a questionnaire with self-screening psoriasis questions including prototypical color pictures.

Results

Of the 592 questionnaires sent, 448 (75.7%) were eligible for analysis. Of these 448 respondents, 58 (13%) had a positive self-screening for psoriasis symptoms, currently or in the past. In 28 (48%) of 58 patients, psoriasis diagnosis could be verified by medical records, resulting in a psoriasis prevalence rate of 6.3%. In comparison with patients with a confirmed psoriasis diagnosis, patients reporting psoriasis symptoms without a verified diagnosis mentioned more mild than moderate-severe psoriasis symptoms (25% vs. 3%, p = 0.02), and their psoriasis lesions were less often located on the torso area (3% vs. 18%, p = 0.04), the intergluteal cleft (0% vs. 25%, p = 0.02), and legs (7% vs. 43%, p < 0.01). Of the 31 axSpA patients who reported currently active psoriasis, 74% had only mild psoriasis symptoms.

Conclusions

Especially mild psoriasis seems often underdiagnosed in patients with axSpA using a patient questionnaire with prototypical pictures of psoriasis lesions. This questionnaire could be beneficial in tracing patients with undiagnosed psoriasis in daily clinical practice. As a next step, further validation of this questionnaire is needed.
Lupus mastitis and antiphospholipid syndrome treated with anticoagulation and immunosuppression: a case report
Authors: He Lauren J. , Quimson Laarni C. , Onajin Oluwakemi , Trotter Kimberly C.
Published: August 2023

Background

Systemic lupus erythematosus is an autoimmune disease that can have cutaneous and systemic manifestations. Lupus panniculitis, also known as lupus mastitis, is a subset of chronic cutaneous lupus erythematosus that involves inflammation of the subcutaneous fat. The pathogenesis of lupus mastitis is not fully understood. Diagnosis involves a combination of skin manifestations, imaging, and pathologic confirmation. Treatment typically includes steroids and antimalarials, with more severe disease requiring additional immunosuppressive medications. This report highlights a case of lupus mastitis treated with rituximab and a possible relationship between this disease process and thrombotic disease.

Case presentation

A 48-year-old African American female with systemic lupus erythematosus and antiphospholipid syndrome presented with new breast lesion. Mammography revealed calcifications and increased density with coarse trabecular pattern. Breast biopsy showed features of cutaneous lupus and occlusive vasculopathy. The patient was diagnosed with lupus mastitis and treated with anticoagulation, rituximab, mycophenolate mofetil, and quinacrine with resolution of her symptoms.

Conclusion

This patient experienced improvement in her breast symptoms with combination therapy including rituximab. There are only two other cases reported in literature of patients with lupus mastitis responding to rituximab, highlighting the possible role of B cell depleting therapy for those who have contraindications to standard treatments for lupus mastitis. While the pathophysiology of lupus mastitis is thought to be immune driven, some literature suggests that associated thrombosis commonly seen may be due to a physiologic overlap similar to antiphospholipid syndrome. The possible relationship between antiphospholipid syndrome and lupus mastitis and the use of antiplatelet and anticoagulation therapy is discussed and may warrant further investigation.
Visceral leishmaniasis–human immunodeficiency virus coinfection in a 52-year-old male in southwest Iran: a case report
Authors: Moogahi Sasan , Tadi Beni Fateme , Tavalla Mehdi , Fasihi-Karami Maryam , Kazemi Forough
Published: August 2023

Background

Leishmaniasis is a rare infectious disease observed in subtropical and tropical areas. This disease that demonstrates different clinical characteristics is caused by intracellularLeishmaniaprotozoan. One of the important countries facing the incidence of this infectious disease is Iran. Recently, human immunodeficiency virus–Leishmaniacoinfection has been indicated in Iran.

Case presentation

In the present case report, we show an atypical case of severe visceral leishmaniasis in a 52-year-old Iranian-Arab male with positive human immunodeficiency virus status. Leishmaniasis was detected by node biopsy and subsequently histopathology evaluations and confirmed by molecular methods.

Conclusions

The current study was the first report of an atypical case of a patient withLeishmania–human immunodeficiency virus coinfection in southwestern Iran, which was not responsive to the treatment. Therefore, the health authorities should be aware of these reports, which require permanent clinical follow-up of the patients as well as effective treatments.
Polish infection control nurses’ job satisfaction and cooperation with their colleagues reflect how the value of infection control is appreciated by other health care workers: findings from surveys conducted before and during the COVID-19 pandemic
Authors: Jaślan Dorota , Rosiński Jerzy , Wałaszek Marta , Majewska Renata , Szczypta Anna , Wójkowska-Mach Jadwiga , Różańska Anna
Published: August 2023

Background

Infection prevention and control (IPC) is based on the activity of specialized, trained and highly qualified personnel, especially infection control nurses (ICNs). Effective implementation of IPC procedures demands close cooperation between IPC teams (IPCTs) and hospital personnel. Based on disturbing results on the epidemiology of health care-associated infections (HAIs) and compliance with preventive procedures, we suspect that cooperation between ICNs and different groups of hospital staff is poor.

The aim of this study was to assess the perceptions of ICNs working in Polish hospitals with regard to difficulties in working with various professional groups in the hospital, their organizational conditions, and their job satisfaction before and after the COVID-19 pandemic.

Methods

The study was conducted twice, in 2014 and 2021, among ICNs working in Polish hospitals. The survey used an anonymous questionnaire designed by the authors.

Results

In 2014, 183 ICNs participated in the study, and 175 ICNs participated in 2021. The respondents’ average age and seniority (duration of work as an ICN) were higher in 2021. Depending on the ward specialty, approximately 30–48.8% of the ICNs had difficulty cooperating with physicians. However, the ICNs declared better cooperation with nurses in various hospital wards and with other professionals. For some groups of hospital staff, there was a negative correlation between poor cooperation and ICNs’ job satisfaction. The job satisfaction data were disturbing; for example, more than half of the respondents considered changing jobs, and the lack of a sense of purpose in their work was declared by 29.7% of ICNs in 2014 and by 54.3% of ICNs in 2021.

Conclusions

Our results suggest that infection prevention and control is not highly appreciated by health care workers and hospital management. Our study reveals difficulties in ICNs’ cooperation with hospital staff and managers in both 2021 and 2014, moderate job satisfaction, a high level of willingness to change jobs, and insufficient training in interpersonal skills and the implementation of changes. These findings clearly indicate an urgent need to introduce modern competence development systems in infection control beyond the scope of traditional training.
Neuropsychiatric involvement in juvenile-onset systemic lupus erythematosus (jSLE)
Authors: Natoli Valentina , Charras Amandine , Hahn Gabriele , Hedrich Christian M.
Published: August 2023

Systemic lupus erythematosus (SLE) is a rare autoimmune/inflammatory disease with significant morbidity and mortality. Approximately 15–20% of SLE patients develop the disease during childhood or adolescence (juvenile-onset SLE/jSLE). Patients with jSLE exhibit more variable and severe disease when compared to patients with disease-onset during adulthood. Neuropsychiatric (NP) involvement is a clinically heterogenous and potentially severe complication. Published reports on the incidence and prevalence of NP-jSLE are scarce, and the exact pathophysiology is poorly understood.

This manuscript provides a review of the existing literature, suggesting NP involvement in 13.5–51% of jSLE patients. Among patients with NP-jSLE affecting the CNS, we propose two main subgroups: (i) a chronic progressive, predominantly type 1 interferon-driven form that poorly responds to currently used treatments, and (ii) an acutely aggressive form that usually presents early during the disease that may be primarily mediated by auto-reactive effector lymphocytes. While this hypothesis requires to be tested in large collaborative international cohort studies, it may offer future patient stratification and individualised care.
Linkage of premature and early menopause with psychosocial well-being: a moderated multiple mediation approach
Authors: Kundu Sampurna , Acharya Sanghmitra Sheel
Published: August 2023

Purpose

Menopause occurring before the age of 40 is premature and between 40 and 44 years age is early, since the natural age of menopause lies between 45 and 50. The endocrine changes that come with menopause include an erratic decline in estrogen levels which affects the brain. Thus, leading to changes in cognitive function in the longer term due to the menopausal transition. The study aims to explore the effect of premature and early menopause on cognitive health, and psychosocial well-being. The moderated multiple mediation hypothesis of the study is that the effect of premature or early menopause is mediated by depression and insomnia, while all the pathways are moderated by smoking habits.

Data and Methods

The study utilized Longitudinal Aging Study in India (LASI), 2017–2018, Wave 1 data. The sample of 31,435 women were aged 45 and above and did not undergo hysterectomy. A moderated multiple mediation model was used to understand the association between premature or early menopause (X), insomnia (M1), depression (M2), moderator (W), and cognitive health (Y), while controlling for possible confounders.

Results

Premature menopause was negatively associated with cognition (β:-0.33; SE:0.12; p < 0.05), whereas positively associated with insomnia (β:0.18; SE:0.03; p < 0.001) and depression (β:0.25; SE:0.04; p < 0.001). There is a moderating effect of smoking or tobacco consumption has a significant moderating effect on the pathways among premature menopause, depression, insomnia and cognition. When the same model was carried out for early menopause (40–44 years), the results were not significant.

Conclusions

The findings emphasize the fact that smoking is associated with premature menopause, depression and insomnia. Women who experienced premature menopause has lower cognitive scores, depressive symptoms and insomnia symptoms, which were higher among those who consumed tobacco. The study, strongly recommends the dissemination of information on the negative effects of tobacco consumption and making more informed choices to maintain a healthy life. More research into various methods and therapy is needed to determine the relationship between the age of early menopause and their psychosocial well-being.
Features of the Earth’s seasonal hydroclimate: characterizations and comparisons across the Köppen–Geiger climates and across continents
Authors: Papacharalampous Georgia , Tyralis Hristos , Markonis Yannis , Máca Petr , Hanel Martin
Published: August 2023

Detailed investigations of time series features across climates, continents and variable types can progress our understanding and modelling ability of the Earth’s hydroclimate and its dynamics. They can also improve our comprehension of the climate classification systems appearing in their core. Still, such investigations for seasonal hydroclimatic temporal dependence, variability and change are currently missing from the literature. Herein, we propose and apply at the global scale a methodological framework for filling this specific gap. We analyse over 13,000 earth-observed quarterly temperature, precipitation and river flow time series. We adopt the Köppen–Geiger climate classification system and define continental-scale geographical regions for conducting upon them seasonal hydroclimatic feature summaries. The analyses rely on three sample autocorrelation features, a temporal variation feature, a spectral entropy feature, a Hurst feature, a trend strength feature and a seasonality strength feature. We find notable differences to characterize the magnitudes of these features across the various Köppen–Geiger climate classes, as well as between continental-scale geographical regions. We, therefore, deem that the consideration of the comparative summaries could be beneficial in water resources engineering contexts. Lastly, we apply explainable machine learning to compare the investigated features with respect to how informative they are in distinguishing either the main Köppen–Geiger climates or the continental-scale regions. In this regard, the sample autocorrelation, temporal variation and seasonality strength features are found to be more informative than the spectral entropy, Hurst and trend strength features at the seasonal time scale.
Cognitive Behavioural and Art-based program (CB-ART): a pilot study in an early parenting centre
Authors: Brown Hilary , Fisher Jane , Cwikel Julie , Sarid Orly , Rowe Heather
Published: August 2023

Background

The period of pregnancy and early motherhood is a substantial life change associated with psychological turbulence. During this period, some women experience symptoms of anxiety and depression of sufficient severity to warrant professional psychological assistance. Psychosocial and psychological interventions are key therapeutic approaches for women at this life stage. There is growing evidence of the value of the arts in the prevention and treatment of mental health problems. Evidence suggests that women prefer psychological interventions that provide social support and shared space for reflection.

Cognitive Behavioural and Art-based intervention (CB-ART) is a novel therapy for prevention and treatment of perinatal mental health problems. The aim of this study was to implement and evaluate CB-ART for acceptability, feasibility, safety and preliminary efficacy among women admitted to a residential early parenting unit.

Methods

The pilot study used a single-centre, mixed-methods pre- and post-test design to evaluate CB-ART among women admitted to a 5-day residential early parenting service in Melbourne, Australia. Participants completed questionnaires before and after attendance at two 1-h CB-ART group sessions on day 2 and day 5 of admission during which field notes were taken. Evaluation interviews were conducted by telephone 1 week after discharge. The Short Profile of Emotional Competence and the Edinburgh Postnatal Depression Scale were used to assess emotional insight and symptoms of depression, respectively. Feasibility, acceptability and safety were assessed using an analysis of field notes, with quantitative data collected by telephone questionnaire and qualitative data by telephone interviews.

Results

Nine participants enrolled in the program; eight provided complete data. Two CB-ART groups were conducted. Before and after comparisons showed that there was an improvement in symptoms of postnatal depression and a marginal improvement in emotional insight. Thematic analysis of qualitative data indicated CB-ART was a feasible and acceptable means of assisting reflection.

Conclusion

The preliminary data indicate that the CB-ART program is a feasible, acceptable and safe addition to the 5-day residential program, with potentially therapeutic benefits. A larger randomised study is required to assess the effects of the CB-ART intervention on symptom measures in this and other postnatal settings.

Trial registration

Australian and New Zealand Clinical Trials Registry, ACTRN126220000354785. Registered 1 January 2022—retrospectively registered.
Obstructive sleep apnea improves with non-invasive hypoglossal nerve stimulation using temporal interference
Authors: Missey Florian , Ejneby Malin Silverå , Ngom Ibrahima , Donahue Mary J. , Trajlinek Jan , Acerbo Emma , Botzanowski Boris , Cassarà Antonino M. , Neufeld Esra , Glowacki Eric D. , Shangold Lee , Hanes William M. , Williamson Adam
Published: August 2023

Background

Peripheral nerve stimulation is used in both clinical and fundamental research for therapy and exploration. At present, non-invasive peripheral nerve stimulation still lacks the penetration depth to reach deep nerve targets and the stimulation focality to offer selectivity. It is therefore rarely employed as the primary selected nerve stimulation method. We have previously demonstrated that a new stimulation technique, temporal interference stimulation, can overcome depth and focality issues.

Methods

Here, we implement a novel form of temporal interference, bilateral temporal interference stimulation, for bilateral hypoglossal nerve stimulation in rodents and humans. Pairs of electrodes are placed alongside both hypoglossal nerves to stimulate them synchronously and thus decrease the stimulation amplitude required to activate hypoglossal-nerve-controlled tongue movement.

Results

Comparing bilateral temporal interference stimulation with unilateral temporal interference stimulation, we show that it can elicit the same behavioral and electrophysiological responses at a reduced stimulation amplitude. Traditional transcutaneous stimulation evokes no response with equivalent amplitudes of stimulation.

Conclusions

During first-in-man studies, temporal interference stimulation was found to be well-tolerated, and to clinically reduce apnea-hypopnea events in a subgroup of female patients with obstructive sleep apnea. These results suggest a high clinical potential for the use of temporal interference in the treatment of obstructive sleep apnea and other diseases as a safe, effective, and patient-friendly approach.

Trial registration

The protocol was conducted with the agreement of the International Conference on Harmonisation Good Clinical Practice (ICH GCP), applicable United States Code of Federal Regulations (CFR) and followed the approved BRANY IRB File # 22-02-636-1279.
The Full Multi-wake Vortex Lattice Method: a detached flow model based on Potential Flow Theory
Authors: Pimentel-Garcia Jesus Carlos
Published: August 2023

One of the main issues concerning the standard Vortex Lattice Method is its application to partially or fully detached flow conditions, where non-linear aerodynamic characteristics appear as the angle of attack increases and/or the aspect ratio decreases. In order to solve such limitations, a pure numerical approach based entirely on the Vortex Lattice Method concepts has been developed. The so-called steady “Full Multi-wake Vortex Lattice Method” comes from the main hypothesis that each discretized element on the body’s surface detaches their own wakes downstream. The obtained results match for lift, drag and moment coefficients for the entire aspect ratio range configurations (under straight wakes and inviscid assumptions). Future unsteady versions of such a multi-wake approach could improve the current results obtained through Vortex Element Methods (as vortons or isolated vortex filaments).
Sclerosing pneumocytoma originated in the middle mediastinum: a case report
Authors: Yoshida Chihiro , Kakizaki Mototsune , Soo Chang Sung , Okamoto Taku
Published: August 2023

Background

Sclerosing pneumocytoma is a benign tumor that occurs mostly in the lungs and very rarely in the middle mediastinum. It may be difficult to diagnose, as its radiological features and histologic heterogeneity mimic malignancy; therefore a histopathologic examination is required to establish a definitive diagnosis.

Case presentation

The patient was a 52-year-old woman who was found to have a tumor in the middle mediastinum on a chest CT scan and was referred to our hospital for resection. We performed a resection of the mediastinal tumor, assuming it was thymoma or teratoma, via video-assisted thoracic surgery. Histopathological analysis of the mediastinal tumor revealed it to be a sclerosing pneumocytoma.

Conclusions

Herein, we presented a case of a very rare sclerosing pneumocytoma originating from the middle mediastinum where video-assisted thoracic surgery allowed for minimally invasive resection and histopathological diagnosis of the tumor. Such procedures should be considered as the histopathological diagnosis of the tumor may help determine the optimal treatment options.
Bowlby's five therapeutic tasks: bringing them up to date for children
Authors: Wilkinson Simon R.
Published: August 2023

Bowlby remained attached to his psychoanalytic roots and conceptualised treatment in terms of one-to-one relationships, albeit acknowledging the need for a family formulation. Bowlby's five therapeutic tasks were never adapted to the current understanding of working with the relationships fostering the development and maintenance of children's attachment strategies. This paper goes through each of Bowlby's five tasks and adapts them to our current understanding of development, with consequences for prioritising family approaches, rather than a secure base alone with a therapist. In doing so I will review the process of achieving security, seeing it as more similar to an allostatic process than a state of homeostasis.
Open quantum behaviour manifested in the double-slit experiment
Authors: Marinho L. S. , de Sá Neto O. P. , Sampaio Marcos , Costa Helder A. S. , da Paz I. G.
Published: August 2023

In certain analyses of quantum systems, it is common to disregard the dissipation effect and focus solely on decoherence. This is because decoherence typically occurs on a much shorter timescale compared to dissipation. However, in order to gain insight into the role of dissipation, we examine the interference pattern in a double-slit experiment while considering both effects. To do so, we establish time scales for decoherence and dissipation and acknowledge the possibility of these effects occurring in close proximity. By comparing the relative intensity and fringe visibility between a purely decoherent model and a model that incorporates both decoherence and dissipation, we observe that when the time scales of decoherence and dissipation are similar, there exists a propagation time interval where dissipation contributes to a faster degradation of quantum features compared to the sole influence of decoherence. Hence, it is crucial to consider both decoherence and dissipation effects, especially when their time scales are closely aligned, to gain a comprehensive understanding of quantum behavior.
Cultural heterogeneity constrains diffusion of innovations
Authors: Pineda Aruane M. , Reia Sandro M. , Connaughton Colm , Fontanari José F. , Rodrigues Francisco A.
Published: August 2023

Rogers' diffusion of innovations theory asserts that the cultural similarity among individuals plays a crucial role on the acceptance of an innovation in a community. However, most studies on the diffusion of innovations have relied on epidemic-like models where the individuals have no preference on whom they interact with. Here, we use an agent-based model to study the diffusion of innovations in a community of synthetic heterogeneous agents whose interaction preferences depend on their cultural similarity. The community heterogeneity and the agents' interaction preferences are described by Axelrod's model, whereas the diffusion of innovations is described by a variant of the Daley and Kendall model of rumour propagation. The interplay between the social dynamics and the spreading of the innovation is controlled by the parameter

, which yields the probability that the agent engages in social interaction or attempts to spread the innovation. Our findings support Roger's empirical observations that cultural heterogeneity curbs the diffusion of innovations.
Enfortumab Vedotin-induced Hyperglycemia and Ileal Conduit Reconstruction-induced Metabolic Acidosis
Authors: Sato Takaaki , Suzuki Hiroshi , Asashima Yuya , Sone Hirohito
Published: August 2023

We report a 76-year-old man who was treated for hyperglycemia and metabolic acidosis after chemotherapy with enfortumab vedotin and pembrolizumab administered after his surgery for bladder cancer. He had an approximately 20-year history of diabetes. His body mass index was 18.6, and he received metformin 1000 mg/day, sitagliptin 50 mg/day, mitiglinide 30 mg/day, and voglibose 0.6 mg/day with hemoglobin A1c was approximately 7%. He underwent total cystectomy and ileal conduit reconstruction. After relapse, he received chemotherapy but later developed hyperglycemia and metabolic acidosis. His hyperglycemia was caused by enfortumab vedotin, and metabolic acidosis was attributable to the ileocecal canal. These symptoms should be remembered as important complications of this standard treatment, which prompted this case report.
On the Development of Peripatus Novæ-Zealandiæ
Authors: Sheldon Lilian
Published: August 2023

The account to be given in this paper is unfortunately by no means a complete one, owing to the difficulties attendant on working at the subject in this country. The great drawback is the difficulty of obtaining the creatures, and as, so far as I know, there is no way of keeping them alive in England, it is necessary to kill them and remove the embryos as soon as they arrive, so that one is by no means certain of obtaining the stages which are required, when one does have the good fortune to obtain a supply of the creatures.
Cost-Effectiveness of [99mTc]Tilmanocept Relative to [99mTc]Sulfur Colloid for Sentinel Lymph Node Biopsy in Early Stage Oral Cavity Cancer
Authors: Choi Karen Y. , Hao Qiang , Carlisle Kathryn , Hollenbeak Christopher S. , Lai Stephen Y.
Published: August 2023

Background

Several studies have demonstrated varying rates of efficacy, reliability, and sensitivity of sentinel lymph node biopsy (SLNB) in identifying occult nodal disease for early stage oral cavity squamous cell carcinoma (OCSCC) depending on the radionuclide agent utilized. No head-to-head comparison of cost or clinical outcomes of SLNB when utilizing [99mTc]tilmanocept versus [99mTc]sulfur colloid has been performed. The goal of this study was to develop a decision model to compare the cost-effectiveness of [99mTc]tilmanocept versus [99mTc]sulfur colloid in early stage OCSCC.

Patients and Methods

A decision model of disease and treatment as a function of SLNB was created. Patients with a negative SLNB entered a Markov model of the natural history of OCSCC parameterized with published data to simulate five states of health and iterated over a 30-year time horizon. Treatment costs and quality-adjusted life-years (QALYs) for each health state were included. The incremental cost-effectiveness ratio (ICER) was then estimated using $100,000 per additional QALY as the threshold for determining cost-effectiveness.

Results

The base case cost-effectiveness analysis suggested [99mTc]tilmanocept was more effective than [99mTc]sulfur colloid by 0.12 QALYs (7.06 versus 6.94 QALYs). [99mTc]Tilmanocept was more costly, with a lifetime cost of $84,961 in comparison with $84,264 for sulfur colloid, however, the overall base case ICER was $5859 per additional QALY, well under the threshold for cost-effectiveness. Multiple one-way sensitivity analyses were performed, and demonstrated the model was robust to alternative parameter values.

Conclusion

Our analysis showed that while [99mTc]tilmanocept is more costly upfront, these costs are worth the additional QALYs gained by the use of [99mTc]tilmanocept.
Catalytic Ammonia Oxidation Using Ammonia Solution under Electrochemical Conditions: Investigation on Axial Ligand of Ruthenium Catalysts
Authors: Toda Hiroki , Kuroki Kaito , Kanega Ryoichi , Yano Tasuku , Yoshikawa Takeshi , Kuriyama Shogo , Himeda Yuichiro , Sakata Ken , Nishibayashi Yoshiaki
Published: August 2023

We have investigated catalytic ammonia oxidation using ruthenium complexes as catalysts under electrochemical conditions. Cyclic voltammetry and bulk electrolysis with an ammonia solution in MeCN are conducted in the presence of a catalytic amount of ruthenium complexes bearing a 2,2′-bipyridine-6,6′-dicarboxylate ligand with various 6-substituted isoquinolines and phthalazine as axial ligands. As a result, the ruthenium complex bearing phthalazines shows the highest catalytic activity at low applied potentials, where up to 319 equivalents of dinitrogen per catalyst are generated.
Integration of single-cell RNA sequencing and spatial transcriptomics to reveal the glioblastoma heterogeneity
Authors: Perdyan Adrian , Lawrynowicz Urszula , Horbacz Monika , Kaminska Bozena , Mieczkowski Jakub
Published: August 2023

Glioblastoma (GBM), a deadly brain tumor, is still one of a few lasting challenges of contemporary oncology. Current therapies fail to significantly improve patient survival due to GBM tremendous genetic, transcriptomic, immunological, and sex-dependent heterogeneity. Over the years, clinical differences between males and females were characterized. For instance, higher incidence of GBM in males or distinct responses to cancer chemotherapy and immunotherapy between males and females have been noted. Despite the introduction of single-cell RNA sequencing and spatial transcriptomics, these differences were not further investigated as studies were focused only on revealing the general picture of GBM heterogeneity. Hence, in this mini-review, we summarized the current state of knowledge on GBM heterogeneity revealed by single-cell RNA sequencing and spatial transcriptomics with regard to genetics, immunology, and sex-dependent differences. Additionally, we highlighted future research directions which would fill the gap of knowledge on the impact of patient’s sex on the disease outcome.
Identification of high-performing antibodies for amyloid-beta precursor protein for use in Western Blot, immunoprecipitation and immunofluorescence
Authors: Ayoubi Riham , Fotouhi Maryam , Worrall Donovan , Southern Kathleen , Laflamme Carl ,   NeuroSGC/YCharOS/EDDU collaborative group,   ABIF consortium
Published: August 2023

The amyloid-beta precursor protein is a transmembrane protein expressed in many tissues and highly concentrated in the brain. The protein is of significant interest due to its involvement in the generation of amyloidogenic β-amyloid peptides, prone to plaque formation that is characteristic of Alzheimer’s Disease. The scientific community would benefit from the availability of high-quality anti-amyloid-beta precursor protein antibodies to enhance reproducible research on this target. In this study, we characterized eleven amyloid-beta precursor protein commercial antibodies for Western blot, immunoprecipitation, and immunofluorescence using a standardized experimental protocol based on comparing read-outs in knockout cell lines and isogenic parental controls. We identified many high-performing antibodies and encourage readers to use this report as a guide to select the most appropriate antibody for their specific needs.
Anaplastic thyroid cancer with life-threatening symptoms in an older female - a case report
Authors: Pawęska Wojciech , Dominik Hanna , Dominik Barbara
Published: August 2023

Introduction: Anaplastic thyroid cancer, also called undifferentiated, is an uncommon and highly aggressive thyroid neoplasm that usually occurs in patients above 60 years of age (mean 65 years). Incidence is about 1-2 cases per million persons a year. [11] It accounts for 1-2% of thyroid cancer cases and probably develops from previously differentiated thyroid neoplasms. [1] Mutations of TP53 gene are most common and exist in 17-80% of patients. Other frequently mutated genes are RAS, BRAF and β-catenin. [3] The metastatic spread tends to occur through hematogenous and lymphatic pathways. The neoplasm presents as a rapidly enlarging neck mass that can cause compression on the neck structures giving symptoms such as dysphagia and dyspnea. Patients with established diagnosis of anaplastic thyroid cancer have very poor prognosis. Mean survival time of patients after confirmed diagnosis is 3 to 6 months and 5-year survival rate is estimated to be 5-14%. [2]

Aim: The aim of this study is to portray the clinical presentation, course and complications of a patient suffering from anaplastic thyroid cancer. This case report includes performed procedures and implemented treatment.

Description of the case: We present a case of an 87-year-old female that was admitted to the hospital with a large thyroid mass, symptoms of dysphagia, dyspnea and significant weight loss. Clinical picture was suspicious of anaplastic thyroid cancer. Further workup included laboratory testing, imaging and FNA biopsy. Surgical procedure of tracheostomy was conducted due to life-threatening dyspnea with consecutive patient’s monitoring in Intensive Care Unit. After achieving clinically stable state the patient was transferred to Clinical Department of Radiotherapy where palliative radiotherapy was initiated.
Technical Note—Data-Driven Profit Estimation Error in the Newsvendor Model
Authors: Siegel Andrew F. , Wagner Michael R.
Published: August 2023

An unbiased forecast of profit is important in most business environments. Typically, forecasts are generated from data. However, in “Technical Note—Data-Driven Profit Estimation Error in the newsvendor model,” Siegel and Wagner identify a strictly positive bias in a natural estimation of expected profit in a data-driven newsvendor model, where managers will expect more profit than will actually be realized, on average. This bias can reach significant proportions (in some cases 50%+) of the true expected profit and could therefore have undesired and damaging effects in the real world. Siegel and Wagner then design a data-driven adjustment that results in an unbiased estimator of expected profit, so that managers may have an accurate forecast of future profit that is free of systematic bias.
QUEM NÃO TEM CÃO, CAÇA COM PÁSSARO: FANTÁSTICO E VIOLÊNCIA EM “A EXPIAÇÃO”, DE SILVINA OCAMPO
Authors: Colaço Raul Da Rocha
Published: August 2023

Na narrativa curta intitulada “A expiação” (2013), Silvina Ocampo traz à tona a obscura convivência de um triângulo amoroso, formado por dois jovens recém-casados e um amigo desse casal, que acaba apaixonado pela esposa do companheiro de infância. Para tanto, a escritora argentina se encarrega de tecer o seu relato em duas frentes: uma que se volta ao presente, isto é, ao momento em que os três personagens mencionados se encontram dentro de um quarto escuro e o marido deseja fazer uma revelação aos outros dois utilizando seus pássaros adestrados; e outra que se centra no passado, ou seja, nas lembranças que a narradora (esposa) recupera sobre todo o seu relacionamento amoroso. Sendo assim, esta proposta de investigação se dedica a avaliar em que medida o uso da violência (seja ela física, psíquica, linguística, etc.) colabora para que haja um efeito fantástico no conto. Nessa perspectiva, são basilares as contribuições de Ricardo Piglia (1999), de Gabriel Giorgi (2016), de Rosalba Campra (2016) e de Byung-Chul Han (2017). Como resultado, aponta-se que o viés fantástico da obra apreciada surge tanto das fraturas linguísticas, oriundas de uma narração sistematicamente despedaçada, como também das repetitivas ações violentas dos canários, seres convertidos, técnica e/ou diabolicamente, em instrumentos de tortura.
O REALISMO MARAVILHOSO COMO CONSTRUTOR IDENTITÁRIO EM ANA Z., AONDE VAI VOCÊ? DE MARINA COLASANTI
Authors: De Carvalho Diógenes Buenos Aires , Sousa Torres Érica
Published: August 2023

O presente artigo tem como objetivo analisar a obra literária Ana Z., aonde vai você? (1999), de Marina Colasanti, à luz do realismo maravilhoso. O principal objetivo é mostrar como os aspectos do imaginário simbólico imprimidos na viagem mágica realizada pela protagonista influencia no seu desenvolvimento identitário. Para tanto, tem-se como aporte teórico os estudos primários do fantástico realizados por Todorov (2017), Ceserani (2006) e Furtado (1980) a fim de conceituar e identificar como o fantástico se ramificou na América Latina. Com base nesses estudos, a narrativa colasantiana analisada explora o realismo maravilhoso, cujos aspectos foram investigados com base nos apontamentos de estudos da área do fantástico e da literatura juvenil. Em vista disso, identificamos a presença de uma intertextualidade com outros trabalhos pertencentes ao acervo da literatura infantil e juvenil mundial, e que as impressões simbólicas da viagem interior realizada por Ana Z. acaba influenciando na construção de sua identidade ao final da jornada.
EDUCAÇÃO EM TEMPOS DE “FAKE NEWS”, JUVENTUDE E ENSINO MÉDIO NA ERA PÓS-VERDADE: UMA REVISÃO INTEGRATIVA
Authors: Dos Santos Alessandra Ferreira , Casagrande Ana Lara , Velozo Aline Debossan
Published: August 2023

Este artigo objetiva analisar a produção de artigos científicos a partir da perspectiva comunicacional da juventude e que se relaciona, portanto, ao Ensino Médio, verificando em que medida a linguagem se alinha às potencialidades apresentadas pelas Tecnologias da Informação e Comunicação (TIC). Ele é proveniente das reflexões empreendidas na pesquisa de mestrado desenvolvida no Programa de Pós-graduação em Educação da Universidade Federal do Mato Grosso (UFMT), que pensa a nova estruturação do Ensino Médio frente à reorganização curricular, ampliação da carga horária no escopo de um modelo definido como mais flexível e voltado ao desenvolvimento do protagonismo juvenil. Trata-se de uma revisão integrativa, que teve como base de dados o Portal de periódicos da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Capes). A partir das definições, critérios e combinações de descritores definidos para o estudo, foram localizadas 378 publicações. A amostra final foi composta por 10 artigos. Os resultados obtidos sugerem o potencial das TIC para a prática pedagógica em sala de aula, na educação, uma vez que estão presentes na vida de docentes e estudantes. Quanto à relação da educação com as fake news, demonstra-se a necessidade de pensar a comunicação na cibercultura a partir da apropriação crítica das informações e averiguação da natureza das fontes, aspecto possível a partir do processo de ensino-aprendizagem institucionalizado comprometido com a formação omnilateral dos sujeitos históricos, como expressão de uma sociedade plural.
SEQUÊNCIA DIDÁTICA INVESTIGATIVA UTILIZANDO FAKE NEWS PARA O ENSINO DE IMUNOLOGIA DE FORMA REMOTA
Authors: Da Silva Roberta Mota Alves , Luna Tatiana Gomes da Silva
Published: August 2023

A imunologia tem sido, ao longo de anos, considerada uma disciplina de dificuldade ímpar, apesar de imprescindível para decisões individuais e coletivas no que tange a saúde da sociedade em sua totalidade. Considerando que a escola é uma importante esfera na formação do indivíduo, cabe a esse espaço e ao processo educacional, a formação de cidadãos conscientes de seu poder de escolha em meio a um “mar de fake news”, envolvendo as diversas esferas sociais, em especial à saúde. O presente trabalho, apresenta uma sequência didática, utilizada durante o ensino remoto, como uma alternativa para abordagem dos conteúdos de imunologia no ensino médio. A sequência didática construída foi desenvolvida de forma interdisciplinar e contou com atividades síncronas (S) e assíncronas (A):1) vídeo com perguntas inquietantes (A); 2) Aula expositiva dialogada (S); 3) Pesquisa: é fake ou não (A); 4) Elaboração de tirinhas (A). A validação ocorreu através da pesquisa com estudantes de 1º e 2º anos do ensino médio. Por meio da análise do material confeccionado pelos estudantes, percebeu-se um impacto positivo na aprendizagem, com maior interesse por conteúdos relacionados com o cenário pandêmico. Entretanto, o trabalho relata ajustes metodológicos que ocorreram no percurso devido à fragilidade do ensino remoto. A proposta pode ser facilmente adaptada para o ensino presencial ou híbrido. Por fim, a experiência resultou em um roteiro para professores com uma sequência didática que busca o desenvolvimento do senso crítico e um aprendizado significativo de conceitos básicos de imunologia, fomentar a curiosidade e pesquisa, estimulando o protagonismo estudantil e auxiliando no desenvolvimento de cidadãos aptos para o exercício pleno da cidadania.
PESQUISA NA EDUCAÇÃO BÁSICA: CONTRIBUIÇÕES PARA O ENFRENTAMENTO DAS FAKE NEWS
Authors: Reis Haydéa Maria Marino de SantAnna , Benchimol Geisa Moreira Regazzi Gerk
Published: August 2023

O avanço exponencial das Tecnologias de Informação e Comunicação (TIC) possibilitou a ampliação da coletividade de indivíduos na discussão sobre notícias jornalísticas, como também forneceu as condições para o incremento da disseminação de fake news. Nesse contexto, identificamos a ambiguidade das TIC que, tanto servem para estimular a produção de conhecimento, como apresentam desafios para ações pedagógicas na escola (BAUMAN, 1999, 2009). A partir desse cenário, a escrita deste artigo teve por objetivo analisar os conceitos de informação, conhecimento e fake News, com vistas a descrever como as práticas de leitura interdisciplinares, mediadas por docentes da Educação Básica, descritas na literatura especializada, podem favorecer o desenvolvimento do pensamento crítico, de forma a contribuir para o enfrentamento de fake news. Para isso, o estudo ancorou-se na pesquisa bibliográfica de natureza exploratória, por buscar “desenvolver, esclarecer e modificar conceitos e idéias, tendo em vista a formulação de problemas mais precisos ou hipóteses pesquisáveis para estudos posteriores”, conforme definição dada em Gil (2008, p. 46). Os procedimentos  metodológicos adotados pautaram-se na seleção, organização e interpretação dos conceitos-chave, do conceito de interdisciplinaridade em Kleiman (1999) e Moita Lopes (2004; 2006) e a reflexão sobre o contexto de produção dos textos jornalísticos (Castilho e Coelho, 2014). Concluímos, que é possível estimular o desenvolvimento do pensamento crítico dos alunos, através de  práticas  interdisciplinares de leitura do gênero textual jornalístico (KLEIMAN, 1999), dessa forma a escola pode contribuir para o combate de fake news.
FORMAR PARA MUDAR E NÃO PARA ACOMODAR: PESQUISANDO O COTIDIANO E A CIBERCULTURA EM TEMPOS DE PÓS-VERDADE
Authors: De Almeida Wallace Carriço , Dos Santos Edméa Oliveira
Published: August 2023

Relatamos a experiência de pesquisa com o dispositivo Reglus, na compreensão do contexto da emergência das fake news e suas repercussões na contemporaneidade para atuar na formação docente para atuar em tempos de pós-verdade. Partimos das noções de fake news, desinformação e pós-verdade (SANTAELLA, 2018) para o diálogo com um repertório teórico-metodológico situado na multirreferencialidade (ARDOINO, 1998), nas pesquisas com os cotidianos (CERTEAU, 2008; ALVES, 2009, 2019) tendo como método e opção política uma prática de pesquisa que promove uma imersão e ação de co-autoria no campo, formando e se formando no intercâmbio com os praticantes culturais (SANTOS, 2005, 2019). O campo da pesquisa foi o cotidiano da disciplina “Informática na Educação” do curso de Pedagogia a distância pela UERJ/CEDERJ/UAB vivido em perspectiva de investigar como essa guerra de narrativas vem modificando as formas de atuação e formação docente.
MECANISMOS DE CONSOLIDAÇÃO DA CULTURA DA IGNORÂNCIA: O COTIDIANO DE UM GRUPO ANTI-VACINA
Authors: Borges dos Santos Matheus Lincoln , Leite Alvaro Emilio , Lambach Marcelo
Published: August 2023

Pesquisa que apresenta e discute o conceito de agnotologia, a consolidação da cultura da ignorância e sua proliferação por meio das tecnologias digitais, especialmente àquelas que, por meio da internet, possibilitam a divulgação de mensagens em massa nas redes sociais. Discute-se os mecanismos utilizados por alguns segmentos da sociedade, tais como, o político, o econômico e o religioso, para atacar e descontruir o conhecimento científico legitimado ao longo dos tempos. Como trabalho empírico, apresenta-se a análise de mensagens de um grupo de Telegram com aproximadamente 2600 integrantes em que se evidência a construção e disseminação de notícias falsas sobre vacinas e tratamento precoce contra a Covid-19. Os resultados mostram que pelas postagens do grupo circulam materiais e conteúdo nos quais utiliza-se o recurso da criação da dúvida, do conflito, de propagandas institucionalizadas, do apelo emocional e da divulgação de notícias verdadeiras imiscuídas entre as falsas para dar credibilidade à desinformação que se pretende espraiar.  Por fim, reafirma-se o papel do Ensino de Ciências, bem como a importância do letramento científico e midiático para o combate da agnotologia.
ENTRE A ANCESTRALIDADE E A CIBERCULTURA: UM ESTUDO DE REVISÃO SOBRE TECNOLOGIAS DIGITAIS E POVOS INDÍGENAS
Authors: Lima Afonso Dos Santos , Cruz Junior Gilson
Published: August 2023

Este trabalho tem o objetivo de compreender as relações existentes entre povos indígenas e tecnologias digitais no âmbito da produção científica brasileira. Trata-se de uma investigação vinculada ao campo de conhecimento das tecnologias educacionais, caracterizando-se como uma pesquisa qualitativa de caráter exploratório, do tipo revisão sistemática de literatura, que reuniu e analisou o total de 11 trabalhos sobre a temática. Como resultado, aponta que a popularização crescente de tecnologias digitais nos territórios indígenas tem oportunizado novas formas de participação e expressão aos povos tradicionais no ciberespaço. Por outro lado, essa interação também tem gerado debates acerca do suposto enfraquecimento de tradições ancestrais em decorrência da crescente imersão de diferentes etnias na cultura digital.
DA UNIVERSIDADE AO SOM DAS FLAUTAS TUYUKA: DIALOGANDO COM O CONHECIMENTO ANCESTRAL E A EDUCAÇÃO INDÍGENA, A PARTIR DE UMA EXPERIÊNCIA NA COMUNIDADE NOSSA SENHORA DO LIVRAMENTO, RIO NEGRO, AMAZONAS
Authors: Da Silva Jhonatan Gomes , Barreto Jussara Garcez , De Matos Silvanira Gomes , Bettiol Célia Aparecida , Da Costa Mauro Gomes
Published: August 2023

O texto tem por objeto de análise uma atividade de campo realizada no espaço de vivência dos Tuyuka que residem na Comunidade Nossa Senhora do Livramento, localizada à margem esquerda do Baixo Rio Negro, Igarapé do Tarumã Mirim, Reserva de Desenvolvimento Sustentável do Tupé (RDS-Tupé), no Município de Manaus/AM. Sendo a experiência de observação participante, proporcionada pela visita de campo, o viés da extensão do diálogo entre a teoria e a prática envolvendo as aulas da disciplina Sociedades Indígenas e Educação nas quais se discute temas como: as identidades culturais específicas da Amazônia e os conhecimentos da ancestralidade indígena que refletem na educação, modo de vida, arte musical dos povos originários. Assim, conhecer in loco os saberes ancestrais e educacionais Tuyuka compõe a base fundamental para o entendimento e a compreensão dos saberes ancestrais que utilizam suas pedagogias específicas e diferenciadas na sua formação e educação, as quais faz-se necessário tecer diálogos.