bluuebunny/crossref_metadata_2025 huggingface dataset:
Microfluidic Immunoaffinity Basophil Activation Test for Point-of-Care Allergy Diagnosis
Authors: Aljadi Zenib , Kalm Frida , Ramachandraiah Harisha , Nopp Anna , Lundahl Joachim , Russom Aman
Published: May 2019

Background

The flow cytometry-based basophil activation test (BAT) is used for the diagnosis of allergic response. However, flow cytometry is time-consuming, requiring skilled personnel and cumbersome processing, which has limited its use in the clinic. Here, we introduce a novel microfluidic-based immunoaffinity BAT (miBAT) method.

Methods

The microfluidic device, coated with anti-CD203c, was designed to capture basophils directly from whole blood. The captured basophils are activated by anti-FcεRI antibody followed by optical detection of CD63 expression (degranulation marker). The device was first characterized using a basophil cell line followed by whole blood experiments. We evaluated the device with ex vivo stimulation of basophils in whole blood from healthy controls and patients with allergies and compared it with flow cytometry.

Results

The microfluidic device was capable of capturing basophils directly from whole blood followed by in vitro activation and quantification of CD63 expression. CD63 expression was significantly higher (P = 0.0002) in on-chip activated basophils compared with nonactivated cells. The difference in CD63 expression on anti-FcεRI-activated captured basophils in microfluidic chip was significantly higher (P = 0.03) in patients with allergies compared with healthy controls, and the results were comparable with flow cytometry analysis (P = 0.04). Furthermore, there was no significant difference of CD63% expression in anti-FcεRI-activated captured basophils in microfluidic chip compared with flow cytometry.

Conclusions

We report on the miBAT. This device is capable of isolating basophils directly from whole blood for on-chip activation and detection. The new miBAT method awaits validation in larger patient populations to assess performance in diagnosis and monitoring of patients with allergies at the point of care.
Prenatal vitamin D and cord blood insulin-like growth factors in Dhaka, Bangladesh
Authors: Bilic Monika , Qamar Huma , Onoyovwi Akpevwe , Korsiak Jill , Papp Eszter , Al Mahmud Abdullah , Weksberg Rosanna , Gernand Alison D , Harrington Jennifer , Roth Daniel E
Published: May 2019

Fetal growth restriction is linked to adverse health outcomes and is prevalent in low- and middle-income countries; however, determinants of fetal growth are still poorly understood. The objectives were to determine the effect of prenatal vitamin D supplementation on the insulin-like growth factor (IGF) axis at birth, to compare the concentrations of IGF-I in newborns in Bangladesh to a European reference population and to estimate the associations between IGF protein concentrations and birth size. In a randomized controlled trial in Dhaka, Bangladesh, pregnant women enrolled at 17–24 weeks of gestation were assigned to weekly oral vitamin D3 supplementation from enrolment to delivery at doses of 4200 IU/week, 16,800 IU/week, 28,000 IU/week or placebo. In this sub-study, 559 woman–infant pairs were included for analysis and cord blood IGF protein concentrations were quantified at birth. There were no significant effects of vitamin D supplementation on cord blood concentrations of IGF-I (P = 0.398), IGF-II (P = 0.525), binding proteins (BPs) IGFBP-1 (P = 0.170), IGFBP-3 (P = 0.203) or the molar ratio of IGF-I/IGFBP-3 (P = 0.941). In comparison to a European reference population, 6% of girls and 23% of boys had IGF-I concentrations below the 2.5th percentile of the reference population. IGF-I, IGF-II, IGFBP-3 and the IGF-I/IGFBP-3 ratio were positively associated with at least one anthropometric parameter, whereas IGFBP-1 was negatively associated with birth anthropometry. In conclusion, prenatal vitamin D supplementation does not alter or enhance fetal IGF pathways.
Bosentan Therapy in a Patient with Failed Fontan Procedure: A Case Report
Authors: Lu Ting , Tang Mi , Wu Zhongshi , Huang Can
Published: May 2019

Background: Increased pulmonary vascular resistance index (PVR) leads to several complications in patients after a Fontan operation. This increase is mainly attributed to the overexpression of endothelin-1 for a long duration after the Fontan procedure. Here, we describe the case of a 3-year-old boy with a failed Fontan operation who was treated with bosentan, an endothelin-1 receptor blocker.
Case report: Cardiac catheterization was performed, which showed a main pulmonary artery pressure (MPAP) of 19 mmHg and PVRI of 5.6 woods/m2. Oral bosentan regimen at a dose of 31.25 mg was initiated twice a day. The treatment was continued as pleural effusion and ascites persisted. No adverse events were observed, and the treatment was well tolerated. Pleural effusion disappeared, and ascites decreased markedly after 4 weeks, whereas the MPAP was 15 mmHg and the PVRI was 4.3 woods/m2. After 3 months of bosentan therapy, the MPAP was 12 mmHg and the PVRI was 4.1 woods/m2.
Conclusion: We observed that bosentan reduces the PVRI and complications such as pleural effusion and ascites after a failed Fontan procedure.
Elementos para la construcción de un modelo de gestión dirigido a la banca comunal en Ecuador
Authors: Montalvo Alemán Yamile Alexandra , Jácome Calvache Victor Julio
Published: May 2019

This article presents approximations for the elaboration of a management model directed to the communal banking for Ecuador. The comparative study of the organizations, Banca Comunal A from Latacunga City and Banco Comunitario B from Quito city, made visible the urgency of management tools appropriates to their realities, considering that their practices and principles –inclusion, mutual aid, solidarity, self-management and democratic participation–, differ from the conventional banking and are framed in the popular and solidarity finances. The qualitative-quantitative information, product of the fieldwork, allowed to understand the internal dynamics and the external relations of the organizations and, later, to establish the basic elements of the management model proposed in this work.
Histiocytic Sarcoma: A Case Series of Extranodal and Nodal Presentations
Authors: Kasinathan Ganesh , Kori Ahlam Naila , Hassan Nurhidayah
Published: May 2019

Introduction: Histiocytic sarcoma is an aggressive malignancy of mature histocytes which often carries a poor prognosis. Histiocytic sarcoma is defined in the World Health Organisation (WHO) classification of histiocytic and dendritic cell neoplasms. Case Presentation: Case 1 depicts a 42 year old Malay gentleman with no premorbids presented to the haematology unit with a three month history of fever, night sweats, unintentional weight loss, left axillary and bilateral inguinal swellings which were progressively enlarging.  Physical examination revealed a medium built gentleman with left axilla, bilateral inguinal lymphadenopathies and hepatosplenomegaly. Excision biopsies of the left axillary and inguinal lymph nodes were compatible with histiocytic sarcoma. He did not have any bone marrow infiltration. He was treated with 6 cycles of CHOP (Cyclophosphamide, doxorubicin, vincristine, prednisolone) polychemotherapy but he subsequently succumbed to severe hemophagocytic syndrome shortly after his 6th CHOP chemotherapy. Case 2 describes a 55-year-old previously healthy Malay gentleman who presented with perianal swelling and weight loss for two months. Physical examination revealed a large perianal swelling measuring 10 cm with bilateral inguinal lymphadenopathies. Anorectal tissue histology was compatible with the diagnosis of histiocytic sarcoma. He underwent a transverse colostomy which was subsequently reversed post-chemotherapy. He completed 6 cycles of CHOP chemotherapy followed by upfront consolidation autologous stem cell transplant. He is currently 9 months in complete remission. Conclusion: Histiocytic sarcoma remains a disease with poor treatment outcomes and high mortality. Understanding the pathogenesis and pathobiology of the disease will provide a future to the development of novel therapies.
O papel da vinculação aos pais e da regulação emocional no investimento esquemático na aparência em jovens adultos
Authors: Da Costa Claro Patrícia , Pinheiro Mota Catarina
Published: May 2019

Os vínculos afetivos que se estabelecem na infância podem ter efeitos no desenvolvimento emocional dos jovens. A vinculação segura pode potenciar a capacidade de regulação emocional e proporcionar uma imagem de si mais positiva, gerando comportamentos ajustados de investimento na aparência. A presente investigação objetivou analisar o papel da vinculação aos pais e da regulação emocional no investimento esquemático na aparência. Foram usados instrumentos de autorrelato numa amostra constituída por 948 jovens adultos (18-30 anos) de ambos os sexos. Evidenciou-se o papel significativo que a qualidade de vinculação aos pais e a regulação emocional assumem no desenvolvimento de um investimento ajustado na aparência. Verificou-se ainda o efeito mediador positivo das dificuldades de regulação emocional entre a inibição da exploração e individualidade mãe e a saliência auto-avaliativa.
Implicit Beliefs, Explicit Practices?
Authors: Årsheim Helge
Published: May 2019

In this article, I discuss how international human rights law (IHRL) interacts with the notions of "implicit" and "lived" religion. More specifically, I examine the capability of Article 9 on the freedom of thought, conscience and religion in the European Convention on Human Rights (ECHR) to provide protection for rights claims that derive from "implicit" and "lived" forms of religion. I develop this argument in three steps: First, I provide a working definition of "implicit" and "lived" religion. Second, I assess the provisions on the freedom of thought, conscience and religion in the ECHR, asking what kinds of "religion" are most likely to gain protections under this instrument. Third, I review some recent cases to come before the European Court of Human Rights (ECtHR), which monitors the ECHR, gauging which forms of religion have been recognized by the court.
Frog in a Pot
Authors: Quillen Ethan
Published: May 2019

Since the 1940s, atheists have played an essential role in re-defining American religion. They have been directly responsible for abolishing sectarian religious education from American public schools. For removing prayer from public schools. For restricting the use of belief affirmations by Americans elected or appointed to federal office. For amending the federal government's definition of "religious training and belief " so that they too might excuse themselves from military service. They have also challenged the theological language of the Pledge of Allegiance, federal funding for faith-based social service programs, and prayer invocations at official legislative meetings. And even on their own, these seven examples tell an exceptional story about American Atheism. But they tell another one as well. Across the sixty-six years in which they were considered by the United States Supreme Court, the Court itself underwent an ideological turn. From "equal justice under law," to justice according to political principles. And from enforcing the separation of church and state, to defending religious establishments in the name of "tradition." By using the first to gauge the progress of the second, this article will tell these two stories.
Pushing the Boundaries
Authors: McFaul Hugh
Published: May 2019

Deconstructing the definitional boundaries between religion and non-religion is recognised as a fruitful area of investigation for scholars of religion. Taking a critical perspective in understanding the gatekeeping practices of legal institutions, norms and practices in shaping the boundary between religion and non-religion is an important aspect of this methodological approach. Investigating legal gatekeeping practices can prompt critical exploration of how they impact on category formation and facilitate analysis of whose interests are served by legally mandated acts of inclusion or exclusion. This discussion will identify recent instances, where the courts have been active in shaping the boundary between religion and non-religion. Firstly, it will consider recent developments in the definitional approach of domestic UK law. Secondly, it will discuss legal responses to the registration of religious groups in Europe and, thirdly, it will explore attempts to extend freedom of religion protections to commercial corporations. Finally, it will offer some concluding remarks on how this survey of recent developments highlights the contemporary configuration of the legal boundaries between religion and non-religion.
Celia Deane-Drummond, A Primer in Ecotheology: Theology for a Fragile Earth
Authors: Doran Chris
Published: May 2019

Celia Deane-Drummond, A Primer in Ecotheology: Theology for a Fragile Earth(Eugene,OR: Cascade Books, 2017), 167 pp., $23.00 (pbk), ISBN: 978-1-4982-3699-7.
Evan Berry, Devoted to Nature: The Religious Roots of American Environmentalism
Authors: Swanson Tod
Published: May 2019

Evan Berry, Devoted to Nature: The Religious Roots of American Environmentalism(Oakland: University of California Press, 2015), 272 pp., $29.38 (pbk), ISBN: 978-0520285-73-6.
J. Baird Callicott, John Van Buren, and Keith Wayne Brown, Greek Natural Philosophy: The Presocratics and their Importance for Environmental Philosophy
Authors: Peterson Mark C. E.
Published: May 2019

J. Baird Callicott, John Van Buren, and Keith Wayne Brown, Greek Natural Philosophy:The Presocratics and their Importance for Environmental Philosophy (San Diego: CognellaAcademic Publishing, 2017), 386 pp., $93.95 (pbk), ISBN: 978-1516528561.
Saturn
Authors: Hathway Liz
Published: May 2019

Using qualitative and re?exive research methodology I explore the cultural role that the planet Saturn plays in contemporary communities of astrologers and the astrological way of life. Through an exploration of Saturn as a mythical ?gure and as symbol, I ?rst discuss astrology’s cultural back­ground and demonstrate that astrologers have a cultural memory that has remained largely loyal to its roots in the Mesopotamian and Hellenistic periods. I then illuminate the way in which for contemporary astrologers sun-sign astrology functions as a contemporary expression of ancient myth. In addition, I examine the importance of the Saturn Return, which has since become an important symbol of transition, a rite of passage, and a modern form of enchantment that not only marks a life transition but also has the potential to effect one.
The Horoscopic Place
Authors: Gunzburg Darrelyn
Published: May 2019

This article investigates whether astrology is an alternative spiritual practice associated with divination, an occurrence beyond normal human experience. Between July 2015 and July 2016 I conducted semi-structured interviews with seven astrologers who had each been practicing, writing, and teaching astrology for twenty-?ve years or more. The interviews concentrated on understanding the space set aside by the astrologers to focus on the horoscope. The results revealed that the astrologers considered the repetitive behaviour of preparation for the consultation a ritual, re?ecting Emile Durkheim’s views that a special place set aside and reinforced by ritual became sacralised. As the astrologers discussed the storied landscape of the horoscope, a moment of recognition by the client allowed the astro­loger to see more deeply into what Henri Lefebvre called the lived space of the imagination. The ensuing conversation opened the way to a much greater depth of understanding between both astrologer and client and generated insights that did not require a connection with the supernatural.
TERPENOIDS FROM THE LEAVES AND STEMS OF DYSOXYLUM TPONGENSE
Authors: Khanh Pham Ngoc , Tai Bui Huu , Huong Tran Thu , Cuong To Dao , Kim Young Ho , Cuong Nguyen Manh
Published: May 2019

Study on chemical constituents from the leaves and stems of Dysoxylum tpongense Pierre resulted in the isolation of six known compounds (1–6). The chemical structures of isolated compounds were identified as cabraleahydroxylactone (1), cabraleahydroxylactone-3-acetate (2), (+) spathulenol (3), b-sitosterol (4), stigmasterol (5), and stigmast-4-en-3-one (6) by comparison of the physicochemical, interpretation of NMR and mass spectral data with that reported in the literature.
OPTIMIZATION OF MEDIUM COMPONENTS FOR THE PRODUCTION OF ECTOINE BY A HALOPHILIC BACTERIUM ISOLATED FROM CAN GIO MANGROVE
Authors: Thuoc Doan Van , Hien Tran Thi
Published: May 2019

The effect of different carbon and nitrogen sources on growth of producer strain was investigated. Sucrose and glucose were found to be suitable carbon sources, and monosodium glutamate was favorable nitrogen source for bacterial cell growth. Optimum salt concentrations for bacterial growth was ranged from 4 to 6%, whereas, NaCl concentrations from 12 to 15% found to be good for ectoine accumulation. Two-step fed-batch fermentation was then designed, biomass and ectoine content were significant increased, maximum CDW of 25 g/l and ectoine content of 10.3% were obtained.
L’approccio agatologico–cristologico al concetto di persona nella riflessione teatrologica–teologica di Hans Urs von Balthasar e di Józef Tischner
Authors: Wołowski Lech
Published: May 2019

In quest’articolo, presentiamo l’approccio contemporaneo alla comprensione teologica del concetto di persona, formatosi nella corrente del pensiero teodrammatico, rappresentato da H. U. von Balthasar e da J. Tischner. Descriviamo gli aspetti fondamentali antropologici (agatologici–dialogici) e teologici (cristologici–trinitari) caratteristici degli approcci di entrambi gli autori. Prestiamo attenzione particolare ai contributi originali di Balthasar e di Tischner al problema preso in esame, soprattutto per quanto riguarda l’uso della terminologia teatrologica nelle considerazioni riguardanti la descrizione teologica del concetto di persona. L’asse dell’analisi la costituisce il paragone tra due teatrologiche–teologiche analogie chiave, riguardante la nozione di persona introdotte dagli autori su menzionati e concernente, rispettivamente, il rapporto ruolo-missione (Balthasar) e quello di maschera-volto (Tischner).
Transcendencja osoby ludzkiej w refleksji filozoficznej kardynała Karola Wojtyły
Authors: Sroczyński Piotr
Published: May 2019

Artykuł przedstawia koncepcje transcendencji osoby wypracowaną przez Karola Wojtyłę. Wyraża się w niej wyższość ludzkiego działania nad aktywnością innych istot. Według Wojtyły przejawia się ona w spełnianiu wolnych duchowych aktów poznawczych i pożądawczych. Opis transcendencji akcentuje fenomenologię czynu ludzkiego jako czynu poznawczego i wolitywnego. Ostateczną, wewnętrzną racją transcendencji osoby według Wojtyły jest jej duchowość.
Laying the Foundation of Medical Professionalism among Pre-clinical Students: Importance of Reflection
Authors: Agarwal Prerna , Rawekar Alka
Published: May 2019

This article was migrated. The article was not marked as recommended. Introduction: The escalating problem of unprofessionalism calls for 'teaching' medical professionalism in a more explicit manner. Early clinical exposure (ECE) presents the issues pertaining to medical professionalism to the students and reflection note writing evokes critical process of thought and analysis required for learning. The two, therefore, may be used for teaching medical professionalism. Methods:Two hundred students of Ist MBBS were taken for ECE to a medical intensive care unit (ICU). There, the students observed different ongoing activities and critical patients, a doctor discussed some cases with them and they also interacted with the relatives of patients admitted in the ICU. Thereafter, students wrote a 'reflection' note describing what did you see? so what? and now what? Students were given an Objective Structured Clinical Examinations (OSCE), one before the ECE and one after it, for assessing any change in their professional behaviour.Analysis of reflection notes was done thematically and of OSCE scores using paired t-test (p<0.05). Results: The analysis of reflection notes revealed the budding of different elements of professionalism among the students. Post-visit OSCE scores also showed significant improvement. Conclusion: Incorporation of reflection with ECE is helpful in laying the foundation of medical professionalism among pre-clinical students.
An Internal Medicine Residency Hospitalist Pathway: A 2-year Follow Up
Authors: Smeraglio Andrea , Kumar Andre , Kaimal Rajani , Singhal Surbhi , Yang Jingkun , Witteles Ronald , Ahuja Neera
Published: May 2019

This article was migrated. The article was not marked as recommended. Purpose: The Stanford Hospitalist Advanced Practice and Education (SHAPE) Program was established in 2015 as a hospital medicine training track within an academic internal medicine residency program. It is unique because it was created and is currently run by residents with a goal of better preparing residents for careers in hospital medicine. The SHAPE curriculum is based on three principles: (1) clinical excellence in hospitalist-relevant clinical areas, (2) academic development through research and quality improvement, and (3) career mentorship. We provide a two-year follow-up since the establishment of SHAPE and resident attitudes toward the program's effectiveness. Methods: We assessed resident attitudes toward the SHAPE Program and subjective readiness to begin practice via electronic survey from 2015 to 2017. Results: 154 out of 324 (47.5%) total internal medicine residents responded to the surveys. Of those, 17 out of 21 (81.0%) were members of SHAPE. Compared to non-hospitalist-bound residents, SHAPE residents reported improved readiness for independent practice (OR 3.39 [95% CI: 1.1-10.9]) and providing care within the specific domain of palliative care. Conclusions: Here we describe the challenges of maintaining a hospitalist curriculum and the successes that have come from the first resident-run hospitalist training program in the country.
Phenology of Campomanesia adamantium (Cambess.) O. Berg in Brazilian Cerrado
Authors: Leão-Araújo Érica Fernandes , Souza Eli Regina Barboza de , Naves Ronaldo Veloso , Peixoto Nei
Published: May 2019

Abstract Campomanesia adamantium is a fruit tree native to Cerrado and important for human consumption as food, herbal medicine and even in the beverage industry. The aim of this study was to evaluate the vegetative and reproductive phenology of C. adamantium plants in the region of Ipameri-GO, the synchronization of phenophases and the correlation with climatic data. Rainfall, relative humidity, average, maximum and minimum temperature, as well as sprouting, flowering and fruiting data of C. adamantium plants were collected between September and December of 2016 and 2017. Graphs were plotted for climatological data and phenological phases. Phenophase synchrony analysis and correlation of these phases with the climate of the region were performed. Sprouting and flowering began before the first rains of the rainy season and the peak of these phenophases occurred in October. Fruiting began in October and peak was observed in November. Sprouting is highly synchronous from the second ten days of October and flowering reveals high synchronicity between the second half of October and the first half of November. Fruiting is considered highly synchronous from the second half of November. Not all plants reach reproductive stages. Sprouting and fruiting are related to the occurrence of rainfall and increase of air RH. Flowering has no correlation with rainfall, air RH and temperature.
Production of parsley in hydroponic conditions under isosmotic brackish nutrient solutions
Authors: Martins Juliana Bezerra , Santos Júnior José Amilton , Silva Júnior Fernando José da , Silva Gerônimo Ferreira da , Medeiros Salomão de Sousa
Published: May 2019

ABSTRACT Brackish waters may vary in their chemical compositions, interfering with different plant responses to stress; therefore, the present study aimed to evaluate the production components of parsley plants subjected to levels of electrical conductivity in nutrient solutions with an initial ECns of 1.58 dS m-1, which was solubilized in water with the following water electrical conductivity configurations (ECw): 0.12 (control), 1.12, 2.12, 3.12, 4.12 and 5.12 dS m-1, resulting in six isosmotic levels (ECns = 1.7, 2.7, 3.7, 4.7, 5.7 and 6.7 dS m-1) in an interaction with four types of salt: NaCl, CaCl2, MgCl2 and KCl. The experimental design was completely randomized in a factorial scheme with five replicates. Two strategies were used to restore the volume consumed by the parsley plants, and the replacement was made with municipal-supply water (ECa = 0.12 dS m-1) in the first strategy and with the respective brackish waters in the second strategy. The total fresh and dry weights of the shoots and roots were evaluated as well as the total dry mass percentage of the shoots and roots. The responses of the plants to the different cationic natures was more evident at the highest levels of electrical conductivity tested, and the use of municipal-supply water to replace the evapotranspired depth mitigated the deleterious effects of salinity. In addition, greater reductions were observed in the fresh and dry mass when the replacement of the volume consumed was with the brackish waters.
Tolerance of crambe (Crambe abyssinica Hochst) to salinity and water stress during seed germination and initial seedling growth
Authors: Silva Martha Freire da , Araújo Eduardo Fontes , Silva Laércio Junio da , Amaro Hugo Tiago Ribeiro , Dias Luiz Antônio dos Santos , Dias Denise Cunha Fernandes dos Santos
Published: May 2019

ABSTRACT Crambe is an oilseed plant whose oil is suitable for various industrial purposes, such as production of biodiesel, plastics, rubbers, and cosmetics. There are reports of the rusticity of this species and its potential for growth in arid and semi-arid environments, where water scarcity and soil salinity are common. However, studies regarding the tolerance of its seeds to these stresses and the physiological responses triggered during germination and seedling establishment under these conditions are incipient. The objective of this study was to evaluate the tolerance of crambe seeds to water deficit and salt stress during germination and early seedling development, as well as to investigate the role of antioxidant enzymes on tolerance to these conditions. The seeds were exposed to water and salt stresses and their performance was analyzed. Seed water content, imbibition rate, percentage and speed of germination, and the base water potential for seed germination were evaluated. In the seedlings, the following measurements were made: root and shoot length, fresh and dry matter of roots and shoots, moisture content, and activity of the enzymes superoxide dismutase (SOD), catalase (CAT), and peroxidase (POX). Water deficit and salt stress reduce the water uptake rate of the seeds, the germination and growth of seedlings. The crambe seeds had higher tolerance to salt stress than to water deficit. Absorption of salt and the action of the SOD and CAT antioxidant enzymes are part of the tolerance mechanisms of crambe seeds to salt stress.
Inéditos-viáveis na formação continuada de educadoras matemáticas
Authors: Alves Rejane de Oliveira , Muniz Cristiano Alberto
Published: May 2019

Resumo: Este artigo resgata o conceito freireano dos inéditos-viáveis e analisa como eles são constituídos por educadoras que ensinam Matemática nos anos iniciais do Ensino Fundamental, a partir da formação continuada em serviço. Os inéditos-viáveis, enquanto conceito que favorece a explicitação de processos de aprendizagens matemáticas, remetem à materialização e às produções matemáticas das educadoras da Educação de Jovens e Adultos. Ancorados na pesquisa participante, realizamos círculos de investigação formativos na escola pública, onde desenvolvemos estudos teóricos e práticas envolvendo conhecimentos matemáticos. Alguns resultados da pesquisa foram: produção de significados nos processos de aprender e ensinar, ampliação dos conceitos matemáticos, valorização do papel formativo da matemática em relação à educação política, ética e moral do sujeito e adoção de práxis emancipadora pelas educadoras. Desse modo, concluímos que os inéditos-viáveis foram constituídos quando o coletivo se utilizou de ações (os atos-limite) para superação dos entraves (as situações-limite) nas sessões formativas, permitindo ampliar conceitos na educação matemática.
Elementos da abordagem temática no Ensino Médio: sinalizações para formação de professoras e de professores
Authors: Silva Luciano Fernandes , Tavares Swellen Sales , Watanabe Giselle , Halmenschlager Karine Raquiel , Strieder Roseline Beatriz , Hunsche Sandra
Published: May 2019

Resumo: Neste trabalho identificam-se elementos que caracterizam a abordagem de temas inseridos na ação de professoras e professores que cursaram Licenciatura em Física e que participaram, ao longo do processo formativo, de discussões sobre Abordagem Temática. A investigação é de natureza qualitativa, sendo utilizados questionários com perguntas abertas e fechadas, assim como entrevistas semiestruturadas. Participaram de todas as etapas desta investigação dezoito sujeitos de oito instituições de Ensino Superior brasileiras. A análise dos dados foi realizada com base nos princípios da análise de conteúdo, a partir de duas categorias: natureza do tema e critérios de seleção das temáticas. Dentre os resultados, destaca-se que os e as docentes, predominantemente, têm desenvolvido temáticas contextuais selecionadas a partir do interesse e/ou do cotidiano dos(as) estudantes, indicando preocupação com a significação dos conceitos científicos escolares a partir do estabelecimento de relações entre aspectos da vivência da(o) aluna(o) e do conteúdo conceitual escolar.
Padrões de prática no ensino de ciências pela utilização de um instrumento designado radiografia da prática
Authors: Carmo José Manuel
Published: May 2019

Resumo O artigo descreve uma proposta de instrumento para a recolha de uma descrição operacional da prática de professores que permita aceder aos acontecimentos pedagógicos essenciais que estruturam as suas práticas, ao osso físico da sua teoria prática que se designa radiografia da prática. A metodologia anteriormente proposta para identificar as sequências pedagógicas dos professores é, neste trabalho, utilizada como matriz interpretativa pelo investigador das descrições da prática dos professores, experimentando a sua utilidade e contribuindo para a validação dos pressupostos na sua construção. No artigo descreve-se o procedimento metodológico na sua aplicação a um conjunto de professores, o processo de inferência pelo investigador e exemplos dos padrões de prática encontrados no grupo estudado: um padrão mais radicalmente transmissivo, um padrão transmissivo baseado numa atividade prática e um padrão com marcas construtivistas.
Transversalizando conteúdos de Física no ensino médio: o efeito estufa causado pela pecuária
Authors: De-Carvalho Roberth , Matei Ana Paula
Published: May 2019

Resumo Transversalizar conteúdos em Ciências da Natureza requer um trabalho pedagógico atento de contextualização com a realidade vivencial dos educandos. Nesse sentido, por sequenciamento de ações didáticas no Ensino de Física, compôs-se uma estratégia psicopedagógica com o objetivo de desenvolver uma consciência crítica em um grupo de estudantes de Ensino Médio noturno, abordando uma questão socioambiental: o efeito estufa decorrente de atividades pecuaristas. Em uma abordagem qualitativa e com procedimentos de pesquisa participante, implementou-se um Plano de Ações Pedagógicas Transversais (PAPT) em uma escola pública do município de Blumenau, em Santa Catarina, a partir do qual foram aperfeiçoadas as representações socioambientais nos estudantes. Concluiu-se que o trabalho pedagógico de organização desse sequenciamento didático instigou discursos tecnocientíficos por transições de linguagem dos estudantes quanto ao consumo de animais e seus subprodutos, gerados por atividades agropecuárias, formando concepções críticas para uma cidadania ativa e participativa.
Alveolodental ankylosis: biological bases and diagnostic criteria
Authors: ROSA Duane Cristina Lopes , SIMUKAWA Ewerton Raphael , CAPELOZZA Ana Lúcia Alvares , CARVALHO Paulo Sergio Perri de , RODRIGUES Moacyr Tadeu Vicente
Published: May 2019

ABSTRACT Alveolodental ankylosis is the fusion of cementum or root dentin with the alveolar bone in both deciduous and permanent teeth. This leads to important clinical and radiographic changes in the affected teeth. Moreover, knowledge of the biological principles involved allows adequate management of teeth affected by this phenomenon.
Inflammatory fibrous hyperplasia: a rare case in a child
Authors: FIGUEIREDO Carla Vânia de Oliveira , CALVO Ana Flávia Bissoto , MELO Auremir Rocha , IMPARATO José Carlos Pettorossi
Published: May 2019

ABSTRACT This paper aims to describe an inflammatory fibrous hyperplasia case caused by chronic irritation due to poor dental positioning after trauma. An 11-year-old female patient was sent to a dental specialty center with the complaint of a soft tissue growth in the place of an unerupted maxillary central incisor, causing her behavioral changes becoming more timid. After anamnesis and clinical examination it was noted that tooth 11 was in a vestibular position, covered with a hyperplastic lesion. Surgical treatment was performed and the histopathological exam revealed inflammatory fibrous hyperplasia. Over the course of the follow-up appointments, it was possible to observe improvement on the mentioned tooth and the patient’s satisfaction. In face of the low prevalence of inflammatory fibrous hyperplasia, it is worth mentioning that the tooth positioning, outside its correct alignment in the arch, can cause repeated trauma to the mucosa, and then turning into etiological factor to inflammatory fibrous hyperplasia, affecting even children and adolescents. Thus, the dentistry must be alert to establish a diagnosis and clinical treatment, in addition to monitoring these cases.
Spatial distribution of decayed and restored teeth in an adult population
Authors: SILVA-JUNIOR Manoelito Ferreira , FONSECA Emílio Prado da , BATISTA Marília Jesus , SOUSA Maria da Luz Rosário de
Published: May 2019

ABSTRACT Objective To analyze the spatial distribution of decayed and restored teeth in adults according to the Social Exclusion Index (SEI) and the proximity of public dental service. Methods: This ecological study used secondary data from an epidemiological survey of oral health and from the Piracicaba Research and Planning Institute (IPPLAP). The oral examinations of the DMFT index examined in households by a single examiner calibrated in 2011, by probability sampling, 248 adults (aged 20 to 64 years) representing the residents in Piracicaba-SP, Brazil. Data on social exclusion and health units with dental service were extracted from IPPLAP. We performed georeferencing of the census tracts selected by draw in the epidemiological survey and their respective districts, in addition to the health units with dental service in a radius of 500 m and 1000 m. Spearman’s rank correlation coefficient was analyzed (p<0.05). Results: The smallest value of SEI, that is, the highest social exclusion, showed no correlation with decayed teeth (p=0.09), but had strong positive correlation with restored teeth (r=0.79; p<0.0001). Presence of public dental service in the vicinity of 500 m and 1,000 m showed no correlation, respectively, with the average number of decayed (p=0.07 and p=0.58) and restored (p=0.26 and p=0.56) teeth. Conclusion: Although the correlation between social exclusion and caries in adults was not observed, its case management, namely, the restored teeth, showed correlation with social inequalities. Presence of public dental service showed no correlation with components of caries experience evaluated in this study.
Degradação sazonal de efluentes têxteis por processo foto-Fenton solar mediado por ferrioxalato: descoloração e comportamento dos sólidos
Authors: Justino Naiara Mottim , Battistelli André Aguiar , Lapolli Flávio Rubens , Lobo-Recio Maria Ángeles , Souza Kely Viviane de , Nagel-Hassemer Maria Eliza
Published: May 2019

RESUMO Neste trabalho foi avaliado o processo foto-Fenton solar mediado por ferrioxalato como tratamento primário de um efluente têxtil bruto (E1) e como um processo de polimento, após processo de lodos ativados (E2). Por um ano, ao menos uma vez por mês, a eficiência de descoloração e o comportamento dos sólidos foram avaliados sob condições naturais de radiação, temperatura e características dos efluentes. As condições operacionais foram as seguintes: 50 mg L-1 de ferro, pH 5, 525 mg L-1 de H2O2, administrados em dosagens decrescentes. O oxalato foi adicionado na razão molar de 1:3 [Fe+3:(C2O4)-2]. A descoloração máxima de E1 foi de 67% para intensidade de radiação de 690 W m-2; já a de E2 foi de 95% para intensidade de 620 W m-2. Houve considerável aumento na turbidez e nos sólidos suspensos em função da precipitação do ferro e de sua ação coagulante. A degradação do complexante durante o processo no E2 em dias ensolarados provocou elevada sedimentabilidade dos sólidos do efluente final, resultando em um sobrenadante clarificado, o que não ocorreu em dias nublados.
Influência da idade do lodo na colmatação das membranas em um biorreator à membrana tratando esgoto sanitário
Authors: Belli Tiago José , Battistelli André Aguiar , Bassin João Paulo , Amaral Miriam Cristina Santos , Lapolli Flávio Rubens
Published: May 2019

RESUMO O presente estudo avaliou o efeito da idade do lodo (θc) no potencial incrustante do licor misto em um biorreator à membrana (BRM) tratando esgoto sanitário. Tal avaliação foi conduzida em BRM construído em escala de bancada, com volume útil de 15 L, operado por 420 dias na modalidade de batelada sequencial. Durante o período experimental, foram aplicadas 3 estratégias operacionais, E-1, E-2 e E-3, em que foram testadas as idades de lodo de 80, 40 e 20 dias, respectivamente. Os resultados revelaram que a utilização da idade de lodo de 20 dias resultou em licor misto com maior potencial incrustante, apresentando, neste caso, uma velocidade de colmatação (VC) das membranas de 1,95 mbar dia-1, aproximadamente 2 vezes maior do que a observada nas idades de lodo de 80 e 40 dias. A maior colmatação observada foi atribuída a maior concentração de produtos microbianos solúveis (PMSs) no licor misto e a maior relação proteínas/polissacarídeos (PN/PS) dos flocos biológicos nesse período em questão. Por outro lado, a aplicação da idade de lodo de 80 dias resultou em menor VC das membranas do BRM, com valor de 0,82 mbar dia-1. Contudo, no período final dessa estratégia foi observado crescimento excessivo de bactérias filamentosas, que se refletiu em piora da filtrabilidade do licor misto e aumento da VC das membranas. De maneira geral, os resultados obtidos mostraram que a aplicação da idade de lodo de 40 dias resultou em licor misto com menor potencial incrustante.
Plano de segurança da água implementado na estação de tratamento de água de Guaraú, em São Paulo
Authors: Ventura Katia Sakihama , Vaz Filho Paulo , Nascimento Simone Gonçalves
Published: May 2019

RESUMO O Plano de Segurança da Água representa a estratégia de previsão de perigos e monitoramento de riscos que podem ameaçar a qualidade da água para consumo humano. O trabalho teve o intuito de estudar o Plano de Segurança da Água implantado na estação de tratamento de água Guaraú, de modo a identificar sua concepção metodológica, seus desafios e suas potencialidades para o controle efetivo do sistema de abastecimento de água. Os documentos que subsidiaram a elaboração do plano foram as recomendações da Organização Mundial da Saúde e as exigências do padrão de potabilidade, previstos pela Portaria nº 2.914/2011, do Ministério da Saúde. Para tratamento de água, a companhia gestora do saneamento na Região Metropolitana de São Paulo adotou a metodologia de Beuken et al. (2008) e a proposta de Brasil (2012) para caracterização do perigo e avaliação de riscos. A avaliação indica que quanto maior o valor atribuído a determinado parâmetro, maior é a atenção necessária a este ao longo do sistema de abastecimento de água. A empresa instituiu o Plano de Segurança da Água para otimizar os processos de tratamento e garantir qualidade na distribuição de água potável de forma eficiente. Essa empresa iniciou discussões internas sobre o instrumento em 2006, identificou uma metodologia que pudesse expressar as diretrizes da política ambiental, elaborou o modelo do Plano de Segurança da Água, realizou reuniões técnicas e implantou o plano na estação de tratamento do Guaraú. Os principais resultados foram a sistematização de registros, a implementação de novos procedimentos, a aquisição de equipamentos, a capacitação técnica e a identificação de pontos de controle. O maior desafio foi implantar um instrumento preventivo viável e dinâmico para gestão hídrica. Ressalta-se que o sucesso do plano depende, entre outros fatores, de dados atualizados, da participação da alta administração e dos ajustes necessários requeridos pela própria metodologia. Há falta de estudos científicos e manuais práticos sobre o tema.
Comportamento hidrodinâmico de sistemas alagados construídos de escoamento horizontal subsuperficial de diferentes proporções geométricas e tempos de operação
Authors: Costa Renan de Almeida , Matos Mateus Pimentel de , Matos Antonio Teixeira de , Sperling Marcos Von
Published: May 2019

RESUMO No presente trabalho, teve-se por objetivo avaliar a influência da proporção geométrica e o tempo de operação na hidrodinâmica do sistema. Para isso, três sistemas alagados construídos de escoamento horizontal subsuperficial (SACs-EHSS) de diferentes razões comprimento:largura (L/B) foram caracterizados no que se refere ao comportamento hidrodinâmico, no início e após três meses de sua operação, durante o tratamento de esgoto sanitário. O comportamento hidrodinâmico foi avaliado por meio da técnica estímulo-resposta, com a injeção de traçador de cloreto de lítio (LiCl), na forma de pulso, e da construção da curva de distribuição dos tempos de residência (DTR), a partir da qual foram extraídos parâmetros que permitiram a análise hidrodinâmica dos sistemas. Verificou-se que todos os SACs-EHSS apresentaram comportamento hidrodinâmico do tipo disperso, embora tenha sido observada correlação inversa entre L/B e o número de dispersão (d) no sistema. O tempo de operação desses sistemas também proporcionou pequena redução no d, em todos os SACs-EHSS.
Avaliação comparativa da pegada de carbono de margarina e manteiga produzidas no Sul do Brasil
Authors: Campos Scheilla , Weinschutz Regina , Cherubini Edivan , Mathias Alvaro Luiz
Published: May 2019

RESUMO A avaliação de ciclo de vida (ACV) é uma técnica de estimativa de impactos ambientais, como emissão de gases de efeito estufa (CO2eq), para geração de produto ou realização de processo. O objetivo deste estudo foi estabelecer a pegada de carbono para a produção da margarina e da manteiga com uso das normas ISO e PAS aplicadas a uma empresa de alimentos localizada na região Sul do Brasil desde a etapa do campo até a sua forma embalada com unidade funcional de 500 g para distribuição. Três cenários foram abordados para a margarina (óleos de soja provenientes do Sul e do Centro-Oeste com e sem desmatamento por queimada) e dois para manteiga (com alocação por massa e econômica). A modelagem foi realizada com dados primários de produção agrícola e da empresa e secundários do ecoinvent ® . A pegada da manteiga com alocação econômica (2,91 kg de CO2eq) foi maior do que a da margarina produzida com soja da mesma região (1,32 kg de CO2eq). Entretanto, esse coproduto autônomo da indústria de laticínio requer alocação mássica para evitar supervalorização, sendo de fato a menor pegada (0,63 kg de CO2eq). A utilização de grãos de soja do Centro-Oeste aumentou a pegada da margarina (1,58 kg de CO2eq), tendo sido muito intensificado quando empregado desmatamento por queimada (2,69 kg de CO2eq). A produção de leite foi o fator deletério preponderante para a manteiga. Para a margarina, houve duas situações distintas, sua fabricação quando se usa soja da mesma região ou a produção do grão quando este for proveniente de região distante desmatada por queimada.
Performance of low amorphous silica fly ashes in mortars
Authors: Kaur Amarpreet , Krishnan Sreejith , Bishnoi Shashank
Published: May 2019

Fly ash based cements remain the most consumed pozzolanic cement in developing countries like India. However, despite such high demand, only 60% of the fly ash generated in India is consumed. One of the major reasons for this under-utilisation appears to be the lower quality of Indian fly ashes compared with fly ash generated elsewhere. Fly ashes produced in Indian power plants are generally low-calcium class F fly ash, with a low amorphous fraction (<50%). In the study reported in this paper, an attempt was made to try to understand the impact of low amorphous silica fly ashes on hydration and microstructure variations in blended cement systems using isothermal calorimetry, X-ray diffraction, thermal analysis, scanning electron microscopy and mercury intrusion porosimetry. Durability characteristics were studied by sorptivity measurements. The results showed that the low amorphous silica fly ashes improved both the durability and mechanical performance of the blended cements. These results will be useful in improving fly ash utilisation rates in India by the cement and ready-mix concrete industries.
Are we who we cite?
Authors: Ennser-Kananen Johanna
Published: May 2019

The #metoo movement reaching academia and Applied Linguistics creates a need for discussion on how we as scholars react to oppressive ideologies and behaviors in our community. However, this is not merely a question of processing cases of sexual harassment and assault. More deeply, we need conversations on who we do and do not know, read, and cite, and how to make our field more epistemologically equitable. This article hopes to elicit comments, reactions, and dialogue.
Effects of TCF7L2 rs7903146 variant on metformin response in patients with type 2 diabetes
Authors: Dujic Tanja , Bego Tamer , Malenica Maja , Velija-Asimi Zelija , Ahlqvist Emma , Groop Leif , Pearson Ewan R. , Causevic Adlija , Semiz Sabina
Published: May 2019

The response to metformin, the most commonly used drug for the treatment of type 2 diabetes (T2D), is highly variable. The common variant rs7903146 C>T within the transcription factor 7 like 2 gene (TCF7L2) is the strongest genetic risk factor associated with T2D to date. In this study we explored the effects of TCF7L2 rs7903146 genotype on metformin response in T2D. The study included 86 newly diagnosed patients with T2D, incident users of metformin. Levels of fasting glucose, insulin, HbA1c, total cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides, and anthropometric parameters were measured prior to metformin therapy, and 6 and 12 months after the treatment. Genotyping of TCF7L2 rs7903146 was performed by the Sequenom MassARRAY® iPLEX® platform. At baseline, the diabetes risk allele (T) showed an association with lower triglyceride levels (p = 0.037). After 12 months of metformin treatment, the T allele was associated with 25.9% lower fasting insulin levels (95% CI 10.9-38.3%, p = 0.002) and 29.1% lower HOMA-IR index (95% CI 10.1-44.1%, p = 0.005), after adjustment for baseline values. Moreover, the T allele was associated with 6.7% lower fasting glucose levels (95% CI 1.1-12.0%, p = 0.021), adjusted for baseline glucose and baseline HOMA-%B levels, after 6 months of metformin treatment. This effect was more pronounced in TT carriers who had 16.8% lower fasting glucose levels (95% CI 7.0-25.6%, p = 0.002) compared to the patients with CC genotype. Our results suggest that TCF7L2 rs7903146 variant affects markers of insulin resistance and glycemic response to metformin in newly diagnosed patients with T2D within the first year of metformin treatment.