bluuebunny/crossref_metadata_2025 huggingface dataset:
New Findings on the Sperm Structure of Tenebrionoidea (Insecta, Coleoptera)
Authors: Dias Glenda , Mercati David , Rezende Paulo Henrique , Lino-Neto José , Fanciulli Pietro Paolo , Lupetti Pietro , Dallai Romano
Published: May 2022

The sperm ultrastructure of a few representative species of Tenebrionoidea was studied. Two species belong to the Mordellidae (Mordellistena brevicauda and Hoshihananomia sp.), one species to Oedemeridae (Oedemera nobilis), and one species to Tenebrionidae (Accanthopus velikensis). It is confirmed that Mordellidae are characterized by the lowest number of spermatozoa per cyst (up to 64), a number shared with Ripiphoridae. In contrast, in the two other families, up to 512 spermatozoa per cyst are observed, the same number present, for example, in Tenebrionidae. Also, as in the other more derived families of tenebrionoids studied so far, during spermatogenesis in O. nobilis and A. velikensis, sperm nuclei are regularly distributed in two sets at opposite poles of the cysts. On the contrary, the Mordellidae species do not exhibit this peculiar process. However, during spermiogenesis, the bundles of sperm bend to form a loop in their median region, quite evident in the Hoshihananomia sp., characterized by long sperm. This process, which also occurs in Ripiphoridae, probably enables individuals to produce long sperm without an increase in testicular volume. The sperm looping could be a consequence of the asynchronous growth between cyst size and sperm length. The sperm ultrastructure of the Mordellidae species reveals that they can be differentiated from other Tenebrionoidea based on the shape and size of some sperm components, such as the accessory bodies and the mitochondrial derivatives. They also show an uncommon stiff and immotile posterior flagellar region provided with only accessory tubules. These results contribute to a better knowledge of the phylogenetic relationship of the basal families of the large group of Tenebrionoidea.
Integrative Taxonomy and Synonymization of Aculus mosoniensis (Acari: Eriophyidae), a Potential Biological Control Agent for Tree of Heaven (Ailanthus altissima)
Authors: de Lillo Enrico , Marini Francesca , Cristofaro Massimo , Valenzano Domenico , Petanović Radmila , Vidović Biljana , Cvrković Tatjana , Bon Marie-Claude
Published: May 2022

The taxonomy of Aculus mosoniensis appears to be an unresolved question and its clarification is required, owing to the potential relevance of this mite species as a biological control agent of the tree of heaven. This paper is aimed at giving accurate details on a previously and shortly announced synonymization with Aculops taihangensis, using a morphological and molecular approach. A fusiform morph of A. mosoniensis was distinguished from a vermiform morph and this latter was recognized as deutogyne, which was herein documented. Phylogenetic relationships between Chinese Ac. taihangensis and all A. mosoniensis mites collected in twenty localities in Europe were examined through the analysis of the mitochondrial cytochrome c subunit I (CO1) protein and the nuclear ribosomal internal transcribed spacer 1 region (ITS1). CO1 sequences of Ac. taihangensis from the Shandong province in China and those from mites collected in Austria and Slovenia were 100% identical; the ITS1 sequence of an Ac. taihangensis paratype matched for 99.8% with those obtained from protogynes and deutogynes of A. mosoniensis collected in Italy. All these data supported the announced synonymization of A. mosoniensis with Ac. taihangensis. Aculusmosoniensis was found genetically variable, with five CO1 haplotypes in Europe (becoming eight along with those of Ac. taihangensis) clustering in two highly supported maternal lineages and eight ITS1 haplotypes (becoming nine along with those of Ac. taihangensis) distributed in four supported clades. No overlap between intra- and interspecies distances was observed for both markers and all studied A. mosoniensis populations clustered in one monophyletic mitochondrial clade, suggesting that only one single species might occur in Europe. However, more mite clades may be related to more tree of heaven biotypes with potential ecological differences, which might have potential effects on the biological control and should be investigated.
A Systematic Review of Adherence to Immunosuppression among Pediatric Heart Transplant Patients
Authors: Nassetta Keira , Hussain Tasmeen , Gambetta Katheryn , Le Kevin , O’Dwyer Linda C. , Badawy Sherif M.
Published: May 2022

After pediatric heart transplant, commitment to lifelong immunosuppression is crucial to maintaining graft health. However, a review of the current literature surrounding adherence to immunosuppression in pediatric heart transplant patients is lacking. This systematic review aims to summarize the current landscape of adherence to immunosuppression in pediatric heart transplant patients. We conducted searches in PubMed MEDLINE, Embase, CENTRAL register of Controlled Trials (Wiley), and Scopus, from inception to March 2020. Studies were eligible if they outlined an aspect of adherence to immunosuppression and the measurement of adherence was performed with an objective or otherwise validated measure of adherence (e.g., drug levels, adherence questionnaires). The titles/abstracts of 880 articles were reviewed. After initial screening, 106 articles underwent full text review. As such, 14 articles were included in the final review. Baseline adherence estimates varied greatly, with most values between 40% and 70%. Nonadherence to immunosuppression is associated with worse outcomes (rejection, hospitalization, mortality), impaired quality of life, and mental health concerns in pediatric heart transplant patients. As nonadherence to immunosuppression is common and associated with worse outcomes, there is a need for further development and evaluation of interventions in this space.
Comment on Weitzman et al. Resistance to Antimalarial Monotherapy Is Cyclic. J. Clin. Med. 2022, 11, 781
Authors: van der Pluijm Rob W. , Visser Benjamin J. , Dondorp Arjen M.
Published: May 2022

Weitzman et al. used PubMed text mining to determine the trends of antimalarial resistance over the last 40 years [...]
Renin-Angiotensin-System Inhibitors for the Prevention of Chemotherapy-Induced Peripheral Neuropathy: OncoToxSRA, a Preliminary Cohort Study
Authors: Frachet Simon , Danigo Aurore , Labriffe Marc , Bessaguet Flavien , Quinchard Bianca , Deny Nicolas , Baffert Kim-Arthur , Deluche Elise , Sturtz Franck , Demiot Claire , Magy Laurent
Published: May 2022

Chemotherapy-induced peripheral neuropathy (CIPN) is a frequent and dose-limiting adverse side effect of treatment. CIPN affects the oncological prognosis of patients, as well as their quality of life. To date, no specific pharmacological therapy has demonstrated effectiveness in preventing CIPN. Accumulating preclinical evidence suggests that renin-angiotensin system (RAS) inhibitors may have neuroprotective effects. One hundred and twenty patients were included in this observational study and were followed from the beginning of their neurotoxic chemotherapy schedule until their final assessment, at least one month after its cessation. The National Cancer Institute’s common toxicity criteria 4.0 (NCI-CTC 4.0) were used to grade the severity of adverse events. Follow-ups also included electrochemical skin conductance and scales for pain, quality of life and disability. Among patients receiving a platinum-based regimen, the mean grade of sensory neuropathy (NCI-CTC 4.0) was significantly lower in the RAS inhibitor group after the end of their anticancer treatment schedule. Because of the observational design of the study, patients in the RAS inhibitor group cumulated comorbidities at risk of developing CIPN. Randomized controlled trials in platinum-based regimens would be worth conducting in the future to confirm the neuroprotective potential of RAS inhibitors during chemotherapy.
Nasolabial Appearance in 5-Year-Old Patients with Repaired Complete Unilateral Cleft Lip and Palate: A Comparison of Two Different Techniques of Lip Repair
Authors: Lux Sonja , Mayr Matthias , Schwaiger Michael , Edmondson Sarah-Jayne , Steiner Christoph , Schachner Peter , Gaggl Alexander
Published: May 2022

Different surgical techniques are available to adequately correct the primary cleft lip deformity; however, when compared, none of these techniques have proven superior with regard to achieving optimal aesthetic results. Thus, the aim of this retrospective study was to assess the nasolabial appearance in patients with unilateral cleft lip and palate (UCLP) at age five with reference to two techniques for primary cleft lip repair used in our service: Pfeifer’s wave-line procedure and Randall’s technique. A modified Asher–McDade Aesthetic Index was applied to appraise the nasolabial area by means of 2D photographs of non-syndromic five-year-old patients with a UCLP. In this context, three parameters were assessed: 1. nasal frontal view; 2. shape of the vermilion border and philtrum length; and 3. the nasolabial profile. Five professionals experienced in cleft care were asked to rate the photographs on two occasions. Overall, 53 patients were included in the final analysis, 28 of whom underwent lip repair according to Pfeifer; 25 were treated employing Randall’s technique. Statistically significant differences between the two techniques regarding philtrum length and vermilion border were found (p = 0.046). With reference to the other parameters assessed, no significant differences were determined. The results suggest that Randall’s cleft lip repair may allow for more accurate alignment of the vermilion border and more adequate correction of the cleft lip length discrepancy in comparison to Pfeifer’s wave-line technique.
Comparative Study of Cytokine Storm Treatment in Patients with COVID-19 Pneumonia Using Immunomodulators
Authors: Marc Felicia , Moldovan Corina Maria , Hoza Anica , Magheru Sorina , Ciavoi Gabriela , Farcas Dorina Maria , Sachelarie Liliana , Calin Gabriela , Romila Laura , Damir Daniela , Naum Alexandru Gratian
Published: May 2022

(1) Background: In patients hospitalized with COVID-19 pneumonia, especially moderate and severe forms, a cytokine storm may occur, characterized by the worsening of symptoms and the alteration of biological parameters on days 8–12 of the disease. The therapeutic options for cytokine storms are still controversial, requiring further clarification; (2) Methods: Our study included 344 patients with moderate and severe pneumonia admitted to the internal medicine department who developed a cytokine storm (diagnosed by clinical and biochemical criteria). In group A, 149 patients were treated with Remdesivir and Tocilizumab (together with other drugs, including corticosteroids, antibiotics and anticoagulants), and in group B, 195 patients received Remdesivir and Anakinra. Patients were monitored clinically and by laboratory tests, with the main biochemical parameters being CRP (C-reactive protein), LDH (lactic dehydrogenase) and ferritin; (3) Results: Patients were followed up from a clinical point of view and also by the measurement of CRP, LDH and ferritin at the beginning of therapy, on days three to four and on the tenth day. In both groups, we registered a clinical improvement and a decrease in the parameters of the cytokine storm. In group A, with the IL-6 antagonist Tocilizumab, the beneficial effect occurred faster; in group B, with the IL-1 antagonist Anakinra, the beneficial effect was slower. (4) Conclusions: The use of the immunomodulators, Tocilizumab and Anakinra, in the cytokine storm showed favorable effects, both clinical and biochemical.
One and Five-Year Mortality Risk Prediction in Patients with Moderate and Severe Aortic Stenosis
Authors: Yousef Sameh , Amabile Andrea , Huang Huang , Agarwal Ritu , Singh Saket , Ram Chirag , Milewski Rita K. , Assi Roland , Zhang Yawie , Krane Markus , Geirsson Arnar , Vallabhajosyula Prashanth
Published: May 2022

(1) Background: Our goal was to develop a risk prediction model for mortality in patients with moderate and severe aortic stenosis (AS). (2) Methods: All patients aged 40–95 years, with echocardiographic evidence of moderate and severe AS at a single institution, were studied over a median of 2.8 (1.5–4.8) years, between 2013–2018. Patient characteristics and mortality were compared using Chi-squares, t-tests, and Kaplan–Meier (KM) curves, as appropriate. The risk calculation for mortality was derived using the Cox proportional hazards model. A risk score was calculated for each parameter, and the total sum of scores predicted the individualized risks of 1-and 5-year mortality. (3) Results: A total of 1991 patients with severe and 2212 with moderate AS were included. Severe AS patients were older, had a lower ejection fraction %, were more likely to be Caucasian, and had lower rates of obesity and smoking, but had higher rates of cardiac comorbidities and AVR (49.3% vs. 2.8%, p < 0.0001). The unadjusted overall mortality was 41.7% vs. 41%, p = 0.6530, and was not different using KM curves (log rank, p = 0.0853). The models included only patients with complete follow-up (3966 in the 1-year, and 816 in the 5-year model) and included 13 variables related to patient characteristics, degree of AS, and AVR. The C-statistic was 0.75 and 0.72 for the 1-year and the 5-year models, respectively. (4) Conclusions: Patients with moderate and severe AS experience high morbidity and mortality. The usage of a risk prediction model may provide guidance for clinical decision making in complex patients.
Pre-Interventional 3D-Printing-Assisted Planning of Flow Disrupter Implantation for the Treatment of an Intracranial Aneurysm
Authors: Charbonnier Guillaume , Primikiris Panagiotis , Billottet Benjamin , Louvrier Aurélien , Vancheri Sergio , Ferhat Serine , Biondi Alessandra
Published: May 2022

Intrasaccular flow disrupter devices (ISFD) have opened up new ways to treat intracranial aneurysms but choosing the correct size of ISFD can be challenging. We describe the first use of 3D printing to assist in the choice of ISFD, and we report an illustrative case. We developed a technique that uses preoperative angiography to make a plastic model of the aneurysm. We tested the deployment of different sizes of intrasaccular flow disruptor on the 3D model under fluoroscopy. The best devices were then used as the first-line strategy to treat the patient. The preoperative 3D printing helped in the successful selection of a first-line ISFD, which was not the one recommended by the manufacturer. Three-dimensional printing can provide interesting information regarding the treatment of intracranial aneurysms using ISFD. Further studies are needed to fully assess its benefits.
Effect of Clay’s Multilayer Composites Material on the Energy Efficiency of Buildings
Authors: Ibn-Elhaj Sara , Mounir Soumia , Khabbazi Abdelhamid , Sarghini Hind
Published: May 2022

Climate change and resource and energy depletion are already impacting ecosystems and societies around the world. As a result, environmental sustainability has become one of humanity’s priority challenges. This study aims to use ecological multilayer material in order to reduce the impact of carbon and energy needs of heating in severe climates in which people die each year from cold. The combination of the investigated multilayer material gives a low thermal transmittance (U = 0.361 W·m−2·K−1). A simulation using the software TRNSYS was established to estimate the yearly heating and cooling needs in the building with the developed multilayer material in a semi-arid climate. The yearly energy demands for heating and cooling were compared to a normal wall with conventional bricks; 47% of energy was saved by the use of the multilayer material wall. The use of the multilayer material permits a low ratio of energy needs of 24 KWh/m2/year for cooling needs and 43 KWh/m2/year for heating.
Corncob Cellulose Scaffolds: A New Sustainable Temporary Implant for Cartilage Replacement
Authors: Cordeiro Rachel , Henriques Marta , Silva João C. , Antunes Filipe , Alves Nuno , Moura Carla
Published: May 2022

Tissue engineering using scaffolds is a promising strategy to repair damaged articular cartilage, whose self-repair is inefficient. Cellulose properties have been recognized for their application in the biomedical field. The aim of this study was to fabricate and characterize novel scaffolds based on poly(ɛ-caprolactone) (PCL) and sustainable cellulose. Thus, the performance of corncob-derived cellulose (CC) in scaffolds as an alternative to wood cellulose (WC) was also investigated to reduce the environmental footprint. Two concentrations of CC in scaffolds were tested, 1% and 2% (w/w), and commercial WC using the same concentrations, as a control. Morphologically, all the developed scaffolds presented pore sizes of ~300 µm, 10 layers, a circular shape and well-dispersed cellulose. Thus, all of these characteristics and properties provide the manufactured scaffolds suitable for use in cartilage-replacement strategies. The use of 2% CC results in higher porosity (54.24%), which promotes cell infiltration/migration and nutrient exchange, and has similar mechanical properties to WC. As for the effects of enzymatic degradation of the scaffolds, no significant changes (p > 0.05) were observed in resistance over time. However, the obtained compressive modulus of the scaffold with 2% CC was similar to that of WC. Overall, our results suggest that the integration of 2% corncob cellulose in PCL scaffolds could be a novel way to replace wood-cellulose-containing scaffolds, highlighting its potential for cartilage-replacement strategies.
Governing the Metropolis: An International Review of Metropolitanisation, Metropolitan Governance and the Relationship with Sustainable Land Management
Authors: Moore-Cherry Niamh , Kayanan Carla Maria , Tomaney John , Pike Andy
Published: May 2022

Recent research has identified the potential of the metropolitan scale, and indeed metropolitan bodies, in achieving greater coordination and more effective land-use management. In this paper, we have undertaken a systematic scoping review of the English-language literature (2014–2019) on metropolitanisation and metropolitan governance, with a view to understanding the potential relationship with more sustainable land management. Our scoping review identified several dominant trends within current research on metropolitanisation and metropolitan governance illustrating the complexity between sustainable land management and issues of territorial politics, resourcing, and power relations. The centrality of collaborative working relationships in supporting sustainable land management is identified, yet collaboration and effective metropolitan scale governance is not always an easy task or readily implemented. The paper identifies a series of challenges and concludes that while there is general consensus that the metropolitan arena may be an appropriate scale through which to support more sustainable land management, there is no agreement on the mechanisms to enable this. Steering and more strongly directing metropolitanisation processes through either formal metropolitan governance structures or other tools could provide a potential approach but will require significant adaptation in power and funding structures.
Compressive Strength Estimation of Fly Ash/Slag Based Green Concrete by Deploying Artificial Intelligence Models
Authors: Khan Kaffayatullah , Salami Babatunde Abiodun , Iqbal Mudassir , Amin Muhammad Nasir , Ahmed Fahim , Jalal Fazal E.
Published: May 2022

Cement production is one of the major sources of decomposition of carbonates leading to the emission of carbon dioxide. Researchers have proven that incorporating industrial wastes is of paramount significance for producing green concrete due to the benefits of reducing cement production. The compressive strength of concrete is an imperative parameter to consider when designing concrete structures. Considering high prediction capabilities, artificial intelligence models are widely used to estimate the compressive strength of concrete mixtures. A variety of artificial intelligence models have been developed in the literature; however, evaluation of the modeling procedure and accuracy of the existing models suggests developing such models that manifest the detailed evaluation of setting parameters on the performance of models and enhance the accuracy compared to the existing models. In this study, the computational capabilities of the adaptive neurofuzzy inference system (ANFIS), gene expression programming (GEP), and gradient boosting tree (GBT) were employed to investigate the optimum ratio of ground-granulated blast furnace slag (GGBFS) and fly ash (FA) to the binder content. The training process of GEP modeling revealed 200 chromosomes, 5 genes, and 12 head sizes as the best hyperparameters. Similarly, ANFIS hybrid subclustering modeling with aspect ratios of 0.5, 0.1, 7, and 150; learning rate; maximal depth; and number of trees yielded the best performance in the GBT model. The accuracy of the developed models suggests that the GBT model is superior to the GEP, ANFIS, and other models that exist in the literature. The trained models were validated using 40% of the experimental data along with parametric and sensitivity analysis as second level validation. The GBT model yielded correlation coefficient (R), mean absolute error (MAE), and root mean square error (RMSE), equaling 0.95, 3.07 MPa, and 4.80 MPa for training, whereas, for validation, these values were recorded as 0.95, 3.16 MPa, and 4.85 MPa, respectively. The sensitivity analysis revealed that the aging of the concrete was the most influential parameter, followed by the addition of GGBFS. The effect of the contributing parameters was observed, as corroborated in the literature.
Marginal Bone Loss in Internal Conical Connection Implants Placed at the Crestal and Subcrestal Levels before Prosthetic Loading: A Randomized Clinical Study
Authors: Palacios-Garzón Natalia , Mauri-Obradors Elisabeth , Ayuso-Montero Raúl , Velasco-Ortega Eugenio , Anglada-Cantarell José María , López-López José
Published: May 2022

The vertical position concerning the bone in which the implants are placed has been related as one of the factors causing marginal bone loss. The objective of this study was to evaluate the bone loss that occurs before prosthetic loading around tapered internal connection (CIC) implants placed at the crestal (C) and subcrestal (S) levels. Method: A randomized clinical trial (RCT) was carried out, with a sample size of 62 implants placed in 27 patients who underwent radiological controls on the day of placement, at one month, and at 4 months, and stability was measured by resonance frequency analysis (RFA) on three occasions. Results: Bone loss in implants C and S from the time of placement (T0) and the month after (T1) was not significant (p = 0.54) (C = 0.19 mm and S = 0.15 mm). The difference between one month (T1) and four months (T2) (C = 0.17 mm and S = 0.22 mm) was not significant either (p = 0.26). The difference between the day of placement (T0) and the third and last measurement (T2) was almost null (p = 0.94) (C = 0.35 mm and S = 0.36). The overall success rate of the implants was 97.8%. The stability of the implants measured with RFA went from 70.60 (T0) to 73.16 (T1) and 74.52 (T2). Conclusions: No significant differences were found in the bone loss for implants placed at the C and S levels. The millimeters of bone loss detected in both vertical positions did not have a significant impact on the stability of the implants.
Application of Laser-Induced Breakdown Spectroscopy in the Quantitative Analysis of Elements—K, Na, Ca, and Mg in Liquid Solutions
Authors: Skrzeczanowski Wojciech , Długaszek Maria
Published: May 2022

Results of laser-induced breakdown spectroscopy measurements of K, Na, Ca, and Mg content in liquid media are discussed in the paper. Calibration results show correct parameters—linearity and R2 coefficients of determination at the levels of 0.94–0.99. Obtained regression equations have been used to determine K, Na, Ca, and Mg concentrations in biological samples with known element content. Measurement results showed acceptable, within the expanded standard uncertainty, conformity with their content in the certified materials. Results have been supported by multivariate factorial analysis, which was especially effective for Ca and Mg samples. For these elements, factorial analysis allows the application of the whole spectra to obtain quantitative data on the tested samples, in contrast to a common method based on the selection of a particular spectral line for the calibration.
Stress Triaxiality in Anisotropic Metal Sheets—Definition and Experimental Acquisition for Numerical Damage Prediction
Authors: Rickhey Felix , Hong Seokmoo
Published: May 2022

Governing void growth, stress triaxiality (η) is a crucial parameter in ductile damage prediction. η is defined as the ratio of mean stress to equivalent stress and represents loading conditions. Attempts at introducing material anisotropy in ductile damage models have started only recently, rendering necessary in-depth investigation into the role of η here. η is commonly derived via finite elemnt (FE) simulation. An alternative is presented here: based on analytical expressions, η is obtained directly from the strains in the critical zone. For anisotropic materials, η associated with a specimen varies with yield criterion and material (anisotropy). To investigate the meaning of triaxiality for anisotropic materials, metal sheets made of dual phase steel DP780, and zirconium alloy Zirlo are chosen. Analytical expressions for η are derived for three popular yield criteria: von Mises, Hill48 and Barlat89. Tensile tests are performed with uniaxial tension, notch, and shear specimens, and the local principal strains, measured via digital image correlation (DIC), are converted to h. The uniaxial tension case reveals that only the anisotropic yield criteria can predict the expected η = 1/3. The ramifications associated with anisotropy become apparent for notched specimens, where η differences are highest; for shear specimens, the yield criterion and material-dependence is relatively moderate. This necessitates η and, consequently, the triaxiality failure diagram (TFD) being accompanied by the underlying yield criterion and anisotropy parameters. As the TFD becomes difficult to interpret, it seems more advantageous to provide pairs of principal strain ratio β and failure strain. Suggestions for deriving representative β and η are made.
Modelling Particle Motion during High-Voltage Electrostatic Abrasive Implantation Based on Multi-Physics Field Coupling
Authors: Zheng Huifeng , Wang Wenjie , Gong Liang , Chen Ge
Published: May 2022

Electrostatic abrasive implantation technology is a classical process based on electrostatic field to implant abrasive particles into base material. However, there is still not a quantitative model to ensure the implantation performance due to the fact that the electrostatic abrasive implantation is a complex multi-physics coupled process. To ensure the quality of sandpaper and elucidate the complex motion mechanism of Al2O3 based abrasive particles in a high voltage electrostatic field, a multi-physical field coupling simulation model is proposed. First, the mechanical model is constructed for the complex problem of the electrostatic abrasive implantation process. Then, the field model is established for the problem that the superposition of multi-physical fields leads to complicated environmental conditions. Finally, the evaluation model is established for the problems that the abrasive planting effect is difficult to evaluate and the planting parameters are difficult to adjust. Besides, a tailored electrostatic abrasive planting testing equipment is designed for the implantation performance analysis purpose. Single-parameter electrostatic abrasive planting experiments were conducted to analyze and verify the effect of different pole plate voltage and pole plate spacing on the abrasive implantation rate. To ensure the implantation performance, the applicable pole plate spacing ranges from 30 mm to 50 mm and the suitable voltage is 20–40 kV according to the simulation result in the proposed two models. Meanwhile, the implantation rate experimentation shows the coupling field model coincides with the experiments better. The key factors affecting the electrostatic abrasive planting process are identified, and a feasible multi-physical field coupled abrasive particle motion simulation model is proposed.
Modeling of Adjustable Bending Pipe to Compensate for Pipe Assembly Production Errors
Authors: Fang Yijun , Li Pin , Zhen Xijin , Shen Zongbao
Published: May 2022

The production of pipe assembly for a rocket engine has experienced challenges owing to the higher requirements of the joining and sealing performance. An adjustable laser bending pipe is a flexible and economical means of compensating for production errors after welding, located in the “closing” segment. To improve the productivity and accuracy of the adjustable laser bending pipe, inline measurement systems are integrated into production to develop an adaptive control system. The models of adjustable laser bending pipe to compensate for pipe assembly production errors are established using kinematics and the displacement screw system, and the proposed adaptive control system is validated by the experiment based on the springback-free laser pipe bending process. Using the proposed adaptive control system, the angle deviation decreases from 7.086° to 0.154°, and the distance deviation decreases from 5.076 mm to 0.104 mm. The validation results satisfactorily meet the requirement of the welding axis alignment of the pipe ends. These models demonstrate significant potential to be applied for calculating the feedback parameters required in the adjustments to compensate for pipe assembly production errors.
Introducing a Precise System for Determining Volume Percentages Independent of Scale Thickness and Type of Flow Regime
Authors: Mayet Abdulilah Mohammad , Alizadeh Seyed Mehdi , Kakarash Zana Azeez , Al-Qahtani Ali Awadh , Alanazi Abdullah K. , Alhashimi Hala H. , Eftekhari-Zadeh Ehsan , Nazemi Ehsan
Published: May 2022

When fluids flow into the pipes, the materials in them cause deposits to form inside the pipes over time, which is a threat to the efficiency of the equipment and their depreciation. In the present study, a method for detecting the volume percentage of two-phase flow by considering the presence of scale inside the test pipe is presented using artificial intelligence networks. The method is non-invasive and works in such a way that the detector located on one side of the pipe absorbs the photons that have passed through the other side of the pipe. These photons are emitted to the pipe by a dual source of the isotopes barium-133 and cesium-137. The Monte Carlo N Particle Code (MCNP) simulates the structure, and wavelet features are extracted from the data recorded by the detector. These features are considered Group methods of data handling (GMDH) inputs. A neural network is trained to determine the volume percentage with high accuracy independent of the thickness of the scale in the pipe. In this research, to implement a precise system for working in operating conditions, different conditions, including different flow regimes and different scale thickness values as well as different volume percentages, are simulated. The proposed system is able to determine the volume percentages with high accuracy, regardless of the type of flow regime and the amount of scale inside the pipe. The use of feature extraction techniques in the implementation of the proposed detection system not only reduces the number of detectors, reduces costs, and simplifies the system but also increases the accuracy to a good extent.
Mathematical Simulation of Heat Transfer in Thermally Magnetised Oldroyd-B Fluid in Sakiadis Rheology with a Heat Reservoir
Authors: Zeeshan  , Shah Rasool , Khan Waris , El-Zahar Essam R. , Yook Se-Jin , Shah Nehad Ali
Published: May 2022

Sakiadis rheology of a generalised polymeric material, as well as a heat source or sink and a magnetic field, are all part of this study. Thermal radiations have been introduced into the convective heating process. The translation of a physical situation into a set of nonlinear equations was achieved through mathematical modelling. To convert the resulting partial differential equation into a set of nonlinear ordinary differential equations, appropriate transformations have been used. The velocity and temperature profiles are generated both analytically by HAM and numerically by the Runge–Kutta method (RK-4). In order to analyse the behaviour of the physical quantities involved, numerical and graphical depictions have been offered. To show that the acquired findings are correct, a nonlinear system error analysis has been offered. The heat flux study has been shown using bar charts. For the essential factors involved, the local Nusselt number and local Skin friction are calculated in tabular form. The fluid particles’ molecular mobility was slowed due to the magnetic field and porosity, and the heat transfer rates were demonstrated to be lowered when magnetic and porosity effects are present. This magnetic field and porosity effects regulating property has applications in MHD ion propulsion and power production, the electromagnetic casting of metals, etc. Furthermore, internal heat absorption and generation have diametrically opposed impacts on fluid temperature. The novelty of the present study is that no one has investigated the Sakiadis flow of thermal convection magnetised Oldroyd-B fluid in terms of a heat reservoir across a porous sheet. In limited circumstances, a satisfactory match is revealed when the collected values are compared to the existing work published corroborating the current attempt. The findings of this study are expected to be applicable to a wide range of technical and industrial processes, including steel extrusion, wire protective layers, fiber rolling, fabrication, polythene stuff such as broadsheet, fiber, and stainless steel sheets, and even the process of depositing a thin layer where the sheet is squeezed.
DEA and Machine Learning for Performance Prediction
Authors: Zhang Zhishuo , Xiao Yao , Niu Huayong
Published: May 2022

Data envelopment analysis (DEA) has been widely applied to evaluate the performance of banks, enterprises, governments, research institutions, hospitals, and other fields as a non-parametric estimation method for evaluating the relative effectiveness of research objects. However, the composition of its effective frontier surface is based on the input-output data of existing decision units, which makes it challenging to apply the method to predict the future performance level of other decision units. In this paper, the Slack Based Measure (SBM) model in DEA method is used to measure the relative efficiency values of decision units, and then, eleven machine learning models are used to train the absolute efficient frontier to be applied to the performance prediction of new decisions units. To further improve the prediction effect of the models, this paper proposes a training set under the DEA classification method, starting from the training-set sample selection and input feature indicators. In this paper, regression prediction of test set performance based on the training set under different classification combinations is performed, and the prediction effects of proportional relative indicators and absolute number indicators as machine-learning input features are explored. The robustness of the effective frontier surface under the integrated model is verified. An integrated models of DEA and machine learning with better prediction effects is proposed, taking China’s regional carbon-dioxide emission (carbon emission) performance prediction as an example. The novelty of this work is mainly as follows: firstly, the integrated model can achieve performance prediction by constructing an effective frontier surface, and the empirical results show that this is a feasible methodological technique. Secondly, two schemes to improve the prediction effectiveness of integrated models are discussed in terms of training set partitioning and feature selection, and the effectiveness of the schemes is demonstrated by using carbon-emission performance prediction as an example. This study has some application value and is a complement to the existing literature.
New Monotonic Properties of Positive Solutions of Higher-Order Delay Differential Equations and Their Applications
Authors: Muhib Ali , Moaaz Osama , Cesarano Clemente , Alsallami Shami A. M. , Abdel-Khalek Sayed , Elamin Abd Elmotaleb A. M. A.
Published: May 2022

In this work, new criteria were established for testing the oscillatory behavior of solutions of a class of even-order delay differential equations. We follow an approach that depends on obtaining new monotonic properties for the decreasing positive solutions of the studied equation. Moreover, we use these properties to provide new oscillation criteria of an iterative nature. We provide an example to support the significance of the results and compare them with the related previous work.
Structure Revision of Penipacids A–E Reveals a Putative New Cryptic Natural Product, N-aminoanthranilic Acid, with Potential as a Transcriptional Regulator of Silent Secondary Metabolism
Authors: Khalil Zeinab G. , Kankanamge Sarani , Capon Robert J.
Published: May 2022

Reconsideration of the spectroscopic data for penipacids A–E, first reported in 2013 as the acyclic amidines 1–5 from the South China deep sea sediment-derived fungus Penicillium paneum SD-44, prompted a total synthesis structure revision as the hydrazones 6–10. This revision strongly supported the proposition that penipacids A–B (6–7) were artifact Schiff base adducts of the cryptic (undetected) natural product N-aminoanthranilic acid (11) with diacetone alcohol, induced by excessive exposure to acetone and methanol under acidic handling conditions. Likewise, the revised structures for penipacids C–D (8–9) and E (10) raise the possibility that they may also be artifact Schiff base adducts of 11 and the media constituents pyruvic acid and furfural, respectively. A review of the natural products literature revealed other Schiff base (hydrazone) natural products that might also be viewed as Schiff base adduct artifacts of 11. Having raised the prospect that 11 is an undetected and reactive cryptic natural product, we went on to establish that 11 is not cytotoxic to a range of bacterial, fungal or mammalian (human) cell types. Instead, when added as a supplement to microbial cultivations, 11 can act as a chemical cue/transcriptional regulator, activating and/or enhancing the yield of biosynthetic gene clusters encoding for other natural product chemical defenses. This study demonstrates the value of challenging the structure and artifact status of natural products, as a window into the hidden world of cryptic and highly reactive natural products.
Surgical Outcomes of Total Anomalous Pulmonary Venous Connection Repair
Authors: Jaworski Radoslaw , Kansy Andrzej , Friedman-Gruszczynska Joanna , Bieganowska Katarzyna , Mirkowicz-Malek Malgorzata
Published: May 2022

Background and Objectives: Over the years, surgical repair of total anomalous pulmonary venous connection (TAPVC) outcomes have improved, however, morbidity and mortality still remain significant. This study aims to assess the early and long-term outcomes of surgical treatment of TAPVC children, operated on between 2006 and 2016, in one pediatric center in Poland. Materials and Methods: Diagnostics, surgical treatment, and follow-up data from 83 patients were collected. In addition, survival and risk factor analyses, control echocardiographic, and electrocardiographic examinations were performed. Results: In the analyzed group (n = 83), there were seven hospital deaths (within 30 days after the operation) (8.4%) and nine late deaths (10.8%). The mean follow-up time was 5.5 years, and, for patients who survived, it was 7.1 years. The mean survival time in patients with completed follow-up (n = 70) was 10.3 years; the overall five-year survival rate was 78.4%. Independent mortality risk factors were type I TAPVC, single ventricle physiology, time from admission to operation, intensive care unit stay, postoperative hospital stay, and temporary kidney insufficiency requiring dialysis. Conclusions: The presence of single ventricle physiology and the supracardiac subtype of TAPVC might be negative prognostic factors, while normal heart physiology presents with good post-repair results. This study indicates that cardiac arrhythmias may occur. Morbidity and mortality, related to surgical TAPVC correction, still remain significant.
Influence of Th, Zr, and Ti Dopants on Solution Property of Xe in Uranium Dioxide with Defects: A DFT + U Study
Authors: Pan Liu , Wang Zhen , Wang Qingqing , Liu Zhixiao , Pan Min , Huang Zheng , Wu Lu
Published: May 2022

To ensure the safety and efficient operation of nuclear reactors, it is imperative to understand the effects of various dopants (Ti, Th, and Zr) on the solubility of the fission product Xe in UO2. In this study, Hubbard corrected density functional theory (DFT + U) and occupation matrix control were used to investigate the bulk and defect properties of UO2. The results show that the UO2-Ti system is more favorable for Xe dissolution in vacancies, whereas the UO2-Th system has little effect on the dissolution of Xe atoms. Th, Zr, and Ti inhibit the aggregation of Xe clusters, and Ti is the least favorable for the nucleation and growth of Xe clusters.
Increased Ammonium Toxicity in Response to Exogenous Glutamine in Metastatic Breast Cancer Cells
Authors: Kiesel Violet A. , Sheeley Madeline P. , Donkin Shawn S. , Wendt Michael K. , Hursting Stephen D. , Teegarden Dorothy
Published: May 2022

Several cancers, including breast cancers, show dependence on glutamine metabolism. The purpose of the present study was to determine the mechanistic basis and impact of differential glutamine metabolism in nonmetastatic and metastatic murine mammary cancer cells. Universally labeled 13C5-glutamine metabolic tracing, qRT-PCR, measures of reductive–oxidative balance, and exogenous ammonium chloride treatment were used to assess glutamine reprogramming. Results show that 4 mM media concentration of glutamine, compared with 2 mM, reduced viability only in metastatic cells, and that this decrease in viability was accompanied by increased incorporation of glutamine-derived carbon into the tricarboxylic acid (TCA) cycle. While increased glutamine metabolism in metastatic cells occurred in tandem with a decrease in the reduced/oxidized glutathione ratio, treatment with the antioxidant molecule N-acetylcysteine did not rescue cell viability. However, the viability of metastatic cells was more sensitive to ammonium chloride treatment compared with nonmetastatic cells, suggesting a role of metabolic reprogramming in averting nitrogen cytotoxicity in nonmetastatic cells. Overall, these results demonstrate the ability of nonmetastatic cancer cells to reprogram glutamine metabolism and that this ability may be lost in metastatic cells.
Wavelength Modulation Characteristics of Metal Gratings on Si-Based Blocked-Impurity-Band (BIB) Terahertz Detectors
Authors: Chen Yulu , Dong Zuoru , Zhou Yangzhou , Tao Jiajia , Tong Wulin , Wu Yifei , Liu Wenhui , Wang Bingbing , Dai Xiaowan , Wang Xiaodong
Published: May 2022

In this work, the wavelength selection characteristics of metal gratings on Si-based blocked-impurity-band (BIB) detectors in the terahertz band were studied by performing experiments and a finite difference time domain (FDTD) simulation. The transmission spectra of metal gratings with different periods on 130 μm intrinsic Si substrates were measured. When the metal grating period increased from 16 to 20 to 32 μm, the peak position of the spectrum moved from 21.71 to 24.50 to 36.59 μm, which is in good agreement with the FDTD simulation results. The structure with the period of 32 μm shows the best wavelength selective transmission characteristics. Then, the bare Si-based BIB devices and metal grating/Si-based BIB hybrid devices with different thicknesses of blocking layers of 2 and 5 μm were fabricated. By covering different periods of metal gratings for the devices with a thicker blocking layer of 2 μm, we obtained more effective wavelength selection characteristics and stronger response spectra enhancement ratios that were about 1.3, 2.4, or 1.9 times. This was mainly due to the localized optical field enhancement effect of the plasmons resonance in metal gratings, which decays exponentially in a vertical direction. Our results demonstrate a new approach for the Si-based BIB detector to realize multiband selective detection applications.
Root-Knot Disease Suppression in Eggplant Based on Three Growth Ages of Ganoderma lucidum
Authors: Fatima Saba , Khan Faryad , Asif Mohd , Alotaibi Saqer S. , Islam Khushbu , Shariq Mohammad , Khan Arshad , Ikram Mohd , Ahmad Faheem , Khan Tabreiz Ahmad , Meena Rampratap , Siddiqui Mansoor Ahmad
Published: May 2022

This investigation presents a novel finding showing the effect of culture filtrates (CFs) of macrofungi, Ganoderma lucidum, against Meloidogyne incognita evaluated in vitro and in planta. To determine the nematicidal activity, juveniles of M. incognita were exposed to Ganoderma CFs of three different ages (Two, four and eight weeks old) of pileus and stipe at different concentrations, i.e., 100%, 50%, 10% and 1% for different time intervals (12, 24, 48 and 72 h). Ganoderma species were examined morphologically based on external appearance and analytically using SEM. The ethanolic samples of basidiocarp were prepared and analyzed for in vitro nematicidal assay and different bioactive compounds. The in vitro experiment results revealed that among all three ages of pileus and stipe, two-week-old pileus and stipe exhibited great nematotoxic potency and caused 83.8% and 73.8% juveniles’ mortality at 100% concentration after 72 h of exposure time, respectively. Similarly, the two-week-old pileus and stipe showed the highest egg hatching inhibition of 89.2% and 81.0% at the 100% concentration after five days. The eight-week-old pileus and stipe were not more effective than the two- and four-week-old pileus and stipe. The metabolites were characterized using GC-MS, including sugar alcohol, steroids, silanes, glucosides, pyrones, ester, oleic acid, phthalic acid, linoleic acid, palmitates and ketones. The in planta study conducted in the greenhouse demonstrated that the root dip treatment for 30 min with Ganoderma CFs curtailed the infection level of M. incognita and promoted the eggplant plant growth. The maximum percent increase in plant length, plant fresh weight, plant dry weight, total chlorophyll, carotenoids and yield/plant was obtained at 100% conc. of fungus CFs, whereas a reduction was observed in nematode infestation parameters. It was concluded from the study that Ganoderma CFs can be explored as an effective and eco-friendly antinemic biocontrol agent in fields infected with root-knot nematodes.