bluuebunny/crossref_metadata_2025 huggingface dataset:
Genome‐Wide Meta‐Analysis of Blood Pressure Response to β
1
‐Blockers: Results From ICAPS (International Consortium of Antihypertensive Pharmacogenomics Studies)
Authors: Singh Sonal , Warren Helen R. , Hiltunen Timo P. , McDonough Caitrin W. , El Rouby Nihal , Salvi Erika , Wang Zhiying , Garofalidou Tatiana , Fyhrquist Frej , Kontula Kimmo K. , Glorioso Valeria , Zaninello Roberta , Glorioso Nicola , Pepine Carl J. , Munroe Patricia B. , Turner Stephan T. , Chapman Arlene B. , Boerwinkle Eric , Johnson Julie A. , Gong Yan , Cooper‐DeHoff Rhonda M.
Published: August 2019

Background

There exists a wide interindividual variability in blood pressure (
BP
) response to β
1
‐blockers. To identify the genetic determinants of this variability, we performed a pharmacogenomic genome‐wide meta‐analysis of genetic variants influencing β
1
‐blocker
BP
response.

Methods and Results

Genome‐wide association analysis for systolic BP and diastolic BP response to β
1
‐blockers from 5 randomized clinical trials consisting of 1254 patients with hypertension of European ancestry were combined in meta‐analysis and single nucleotide polymorphisms (SNPs) with
P
<10
−4
were tested for replication in 2 independent randomized clinical trials of β
1
‐blocker–treated patients of European ancestry (n=1552). Regions harboring the replicated
SNP
s were validated in a β
1
‐blocker–treated black cohort from 2 randomized clinical trials (n=315). A missense
SNP
rs28404156 in

BST
1

was associated with systolic BP response to β
1
‐blockers in the discovery meta‐analysis (
P
=9.33×10
−5
, β=−3.21 mm Hg) and replicated at Bonferroni significance (
P
=1.85×10
−4
, β=−4.86 mm Hg) in the replication meta‐analysis with combined meta‐analysis approaching genome‐wide significance (
P
=2.18×10
−7
). This
SNP
in

BST
1

is in linkage disequilibrium with several
SNP
s with putative regulatory functions in nearby genes, including

CD
38

,

FBXL
5

, and

FGFBP
1

, all of which have been implicated in
BP
regulation.
SNP
s in this genetic region were also associated with
BP
response in the
black
cohort.

Conclusions

Data from randomized clinical trials of 8 European ancestry and 2 black cohorts support the assumption that

BST
1

containing locus on chromosome 4 is associated with β
1
‐blocker
BP
response. Given the previous associations of this region with
BP
, this is a strong candidate region for future functional studies and potential use in precision medicine approaches for
BP
management and risk prediction.
IL‐6 Rapidly Induces Reversible Atrial Electrical Remodeling by Downregulation of Cardiac Connexins
Authors: Jalloul Youssef , Refaat Marwan M.
Published: August 2019

See Article
Lazzerini et al
Smoking and TAVR
Authors: Edelman J. James , Thourani Vinod H.
Published: August 2019

See Article
Qintar et al
Morphological and molecular identification of Myxobolus parakoi sp. nov (Myxozoa: Myxobolidae), from Cyprinus carpio in Chongqing China
Authors: LIU XIAOHUA , ZHANG DIAODIAO , YANG CHENGZHONG , ZHAO YUANJUN
Published: August 2019

During an ongoing investigation into the myxosporean diversity of common carp in Chongqing, China, Myxobolus parakoi sp. nov. was found to infect the gill lamellae of Cyprinus carpio (Linnaeus, 1758). Both morphological and SSU rDNA data revealed that M. parakoi sp. nov. was distinct from other myxosporeans. Mature myxospores of M. parakoi sp. nov. were pyriform in the frontal view. The spores were 15.98 ± 0.78 (14.59–17.72) μm in length and 7.84 ± 0.78 (6.66–9.75) μm in width. The two polar capsules were pyriform and equal in size, exhibiting 8.72 ± 0.50 (7.76–9.92) μm in length and 3.03 ± 0.23 (2.63–3.56) μm in width. Polar filaments within the polar capsules were coiled with 11 or 12 turns. Phylogenetic analysis revealed that M. parakoi sp. nov. and Myxobolus koi (FJ710800) were clustered together, forming a sister subclade with Myxobolus tanakai. This study also implied that the morphology of the myxospores was generally correlated with their phylogenetic relationship, while such correlation was not strong or consistent.
Urochordeumatidae Silvestri, 1909, a millipede family endemic to Washington State, USA (Chordeumatida, Striariidea, Striarioidea)
Authors: SHEAR WILLIAM A. , MAREK PAUL E.
Published: August 2019

Urochordeumatidae Silvestri, 1909 includes a single species, Urochordeuma bumpusi Silvestri, 1909, with U. porona Chamberlin, 1941 as a new junior subjective synonym. The family Urochordeumatidae is removed from the superfamily Caseyoidea and transferred to the superfamily Striarioidea. The species is known only from four counties in Washington State in the North Cascades: Pierce, King, Thurston and Whatcom. The occurrence of U. bumpusi from Whatcom County is a significant range extension.
Modulational Stability of Nonlinear Saturated Gravity Waves
Authors: Schlutow Mark
Published: August 2019

Stationary gravity waves, such as mountain lee waves, are effectively described by Grimshaw’s dissipative modulation equations even in high altitudes where they become nonlinear due to their large amplitudes. In this theoretical study, a wave-Reynolds number is introduced to characterize general solutions to these modulation equations. This nondimensional number relates the vertical linear group velocity with wavenumber, pressure scale height, and kinematic molecular/eddy viscosity. It is demonstrated by analytic and numerical methods that Lindzen-type waves in the saturation region, that is, where the wave-Reynolds number is of order unity, destabilize by transient perturbations. It is proposed that this mechanism may be a generator for secondary waves due to direct wave–mean-flow interaction. By assumption, the primary waves are exactly such that altitudinal amplitude growth and viscous damping are balanced and by that the amplitude is maximized. Implications of these results on the relation between mean-flow acceleration and wave breaking heights are discussed.
Energy Sinks for Lee Waves in Shear Flow
Authors: Kunze Eric , Lien Ren-Chieh
Published: August 2019

Microstructure measurements in Drake Passage and on the flanks of Kerguelen Plateau find turbulent dissipation ratesεon average factors of 2–3 smaller than linear lee-wave generation predictions, as well as a factor of 3 smaller than the predictions of a well-established parameterization based on finescale shear and strain. Here, the possibility that these discrepancies are a result of conservation of wave actionE/ωL=E/|kU| is explored. Conservation of wave action will transfer a fraction of the lee-wave radiation back to the mean flow if the waves encounter weakening currentsU, where the intrinsic or Lagrangian frequencyωL= |kU| ↓ |f| andkthe along-stream horizontal wavenumber, wherekU≡k⋅V. The dissipative fraction of power that is lost to turbulence depends on the Doppler shift of the intrinsic frequency between generation and breaking, hence on the topographic height spectrum and bandwidthN/f. The partition between dissipation and loss to the mean flow is quantified for typical topographic height spectral shapes andN/fratios found in the abyssal ocean under the assumption that blocking is local in wavenumber. Although some fraction of lee-wave generation is always dissipated in a rotating fluid, lee waves are not as large a sink for balanced energy or as large a source for turbulence as previously suggested. The dissipative fraction is 0.44–0.56 for topographic spectral slopes and buoyancy frequencies typical of the deep Southern Ocean, insensitive to flow speedUand topographic splitting. Lee waves are also an important mechanism for redistributing balanced energy within their generating bottom current.
Modeling of Wake Vortex Radar Detection in Clear Air Using Large-Eddy Simulation
Authors: Kovalev Dmitry A. , Vanhoenacker-Janvier Danielle , Billuart Philippe , Duponcheel Matthieu , Winckelmans Grégoire
Published: August 2019

To detect wake vortices in all weather conditions, lidar and radar sensors are complementary. It is important to determine accurately the limitations of the radar detection in clear air and to determine the parameters influencing the detection. This paper is the first study to present the simulation and analysis of the radar signatures of wake vortices on the basis of state-of-the-art 3D large-eddy simulations. The setup of the large-eddy simulations is described and the evolution of the wake vortices is illustrated for the three simulated cases. A modified version of the model developed by Muschinski et al. is used here for the calculation of the radar-backscattered signal and the second moment of the Doppler spectrum that is used to estimate the wake vortex circulation. The simulator uses two different radar configurations for the retrieval of the circulation, which is compared with the circulation obtained directly from the large-eddy simulations. The retrieval of the circulation is fairly accurate if the level of backscattered signal is high enough above the detection threshold of the radar.
Current Threats to Maintaining a Secure Pharmaceutical Supply Chain in an Online World
Authors: Hertig John B. , Baney Libby , Weber Robert J.
Published: August 2019

Background: Maintaining integrity of the pharmaceutical supply chain is critical to providing medications that are free from adulteration (counterfeit, substandard or unapproved medications), making them safe for patient use. Purchasing pharmaceuticals through the Internet can be associated with a risk of receiving adulterated medicines. Objective: The objective of this study was to review the current threats to maintaining a secure pharmaceutical supply chain, specifically focused on Internet-based procurement of medications. Methods: A review of the literature was conducted along with collating important up to date resources and other publications that provide foundational information to understanding the risks and prevention strategies for online purchasing of pharmaceuticals. Conclusion: The information provided in this article helps to properly inform pharmacy leaders to the resources available to protect against the risks of on-line purchasing of pharmaceuticals.
Effects of Empowerment and Media Use by Women of Childbearing Age on Maternal Health Care Utilization in Developing Countries of Southeast Asia
Authors: Sohn Minsung , Jung Minsoo
Published: August 2019

Despite its importance to maternal health, women’s empowerment in developing countries has yet to be adequately addressed. We investigated the effects of women’s empowerment and media use on maternal antenatal care in Southeast Asian countries. The data originate from the Demographic and Health Surveys conducted in Southeast Asia between 2011 and 2014 (n = 35,905). We conducted Poisson regression and meta-analyses to examine communication inequalities in the media use for the relationships between women’s empowerment and maternal health. Women who had decision-making authority for their own health care (incidence rate ratio [IRR] = 1.03, 95% CI = 1.01–1.05), household purchases (IRR = 1.02, 95% CI = 1.00–1.04), and visiting family or relatives (IRR = 1.05, 95% CI = 1.03–1.07) were more likely to receive health care than were study participants whose partners had the decision-making authority. When we added use of each type of media into the model, the women who read a newspaper daily (IRR = 1.10, 95% CI = 1.03–1.20), listened to the radio at least once a week (IRR = 1.02, 95% CI = 1.01–1.03), and watched television daily (IRR = 1.61, 95% CI = 1.55–1.67) were more likely to receive health care than those who did not use media at all. This study revealed that women’s empowerment and their use of media were related to better maternal health care.
The gender gap in political interest revisited
Authors: Ferrín Monica , Fraile Marta , García-Albacete Gema M , Gómez Raul
Published: August 2019

To what extent does conventional survey measurement capture the political interest of men and women equally well? We aim to answer this question by relying on unique data from a national online survey in Spain, where we used various questions unpacking the standard indicator of political interest. The findings show that men and women nominate different personal political interests. We also find that the gender gap in political interest vanishes once these specific interests are taken into account. This suggests that at least part of the documented gender gap in general political interest might be due to the fact that, when prompted to think about politics, women disregard their own specific political interests and instead focus on the dominant, male-oriented understanding of politics.
Multi-objective optimal control for proactive decision making with temporal logic models
Authors: Chinchali Sandeep P. , Livingston Scott C. , Chen Mo , Pavone Marco
Published: August 2019

The operation of today’s robots entails interactions with humans, e.g., in autonomous driving amidst human-driven vehicles. To effectively do so, robots must proactively decode the intent of humans and concurrently leverage this knowledge for safe, cooperative task satisfaction: a problem we refer to as proactive decision making. However, simultaneous intent decoding and robotic control requires reasoning over several possible human behavioral models, resulting in high-dimensional state trajectories. In this paper, we address the proactive decision-making problem using a novel combination of formal methods, control, and data mining techniques. First, we distill high-dimensional state trajectories of human–robot interaction into concise, symbolic behavioral summaries that can be learned from data. Second, we leverage formal methods to model high-level agent goals, safe interaction, and information-seeking behavior with temporal logic formulas. Finally, we design a novel decision-making scheme that maintains a belief distribution over models of human behavior, and proactively plans informative actions. After showing several desirable theoretical properties, we apply our framework to a dataset of humans driving in crowded merging scenarios. For it, temporal logic models are generated and used to synthesize control strategies using tree-based value iteration and deep reinforcement learning. In addition, we illustrate how data-driven models of human responses to informative robot probes, such as from generative models such as conditional variational autoencoders, can be clustered with formal specifications. Results from simulated self-driving car scenarios demonstrate that data-driven strategies enable safe interaction, correct model identification, and significant dimensionality reduction.
Bone Regeneration in a Canine Model of Artificial Jaw Cleft Using Bone Marrow–Derived Mesenchymal Stem Cells and Carbonate Hydroxyapatite Carrier
Authors: Abe Takaharu , Sumi Keisuke , Kunimatsu Ryo , Oki Nanae , Tsuka Yuji , Awada Tetsuya , Nakajima Kengo , Sugiyama Masaru , Tanimoto Kotaro
Published: August 2019

Objective:

Cleft lip and palate (CLP) is a common anomaly of the orofacial region. Mesenchymal stem cell (MSC) transplantation has been a focus of regenerative medicine, and its application to the repair of bone defects in patients with CLP is highly anticipated. This study investigated the potential for using MSCs to regenerate bone in a jaw cleft as well as the survival of transplanted MSCs using a canine model of CLP.

Design:

Mesenchymal stem cells collected from the bone marrow of beagle dogs were transplanted along with carbonate hydroxyapatite into jaw clefts in beagle dogs. Mesenchymal stem cells labeled with fluorescent silica nanoparticles were also transplanted, and a histological analysis was performed 3 months later to evaluate MSC survival.

Results:

Carbonate hydroxyapatite regeneration into bone was enhanced by cotransplantation of MSCs. The survival rate of MSCs transplanted after 3 months was 5.7%.

Conclusions:

Transplanted MSCs promote bone regeneration, although their survival rate is low.
Faster Transition From Intravenous to Oral Antihypertensives Associated With Improved Outcomes After Aortic Dissection
Authors: Michaud Christopher J. , Packard Anne E. , Timek Tomasz
Published: August 2019

Background: After stabilization with intravenous (IV) antihypertensives, the impact of speed-of-transition from IV to enteral (PO) medications in the intensive care unit (ICU) is unknown. Objective: To assess ICU length of stay (LOS) based on transition time from IV to PO antihypertensive therapy. Methods: Retrospective study of aortic dissection patients admitted from June 2013 to July 2017 at a tertiary teaching hospital. Patients were grouped based on achieving full transition to PO medications in either ≤72 hours or >72 hours from the first PO dose. Secondary end points included hospital LOS, IV infusion volume, medication cost, and time spent with arterial/central lines. Results: A total of 56 patients transitioned completely from IV to PO therapy in ≤72 hours, and 72 patients required more than 72 hours. Demographics, IV and PO medication choices, and timing of first PO medication administration were similar between groups. ICU LOS was shorter in the group transitioned in ≤72 hours compared with those who took longer to transition (3.6 vs 10.5 days; P < 0.001). Hospital LOS, IV infusion volume, and cost were also significantly lower in the ≤72-hour group ( P < 0.001). The rapid transition group also spent less time with arterial lines (44 vs 156 hours, P < 0.001) and central lines (45 vs 242 hours, P < 0.001). Conclusion and Relevance: In this cohort, transitioning to PO antihypertensives in ≤72 hours was associated with shorter ICU LOS and improvement in other measured outcomes. These observational data are the first to describe a potentially critical juncture in postdissection care; a prospective study is warranted.
A Previously Unknown Drug-Drug Interaction Is Suspected in Delayed Elimination of Plasma Methotrexate in High-Dose Methotrexate Therapy
Authors: Ishizaki Junko , Nakano Chihiro , Kitagawa Kana , Suga Yukio , Sai Yoshimichi
Published: August 2019

Background: High-dose methotrexate (HD-MTX) therapy is widely implemented for leukemia, osteosarcoma, and lymphoma. Although various measures have been taken to avoid toxicity from high serum MTX concentrations, there are many cases of delayed elimination of MTX. Objective: We suspected that delayed elimination of serum MTX was caused by unknown interactions between MTX and concomitant drugs. Methods: Concerning concomitant drugs in the case of delayed elimination of MTX, we performed screening tests in 35 patients who had undergone HD-MTX therapy. We then investigated the risk factors for delayed MTX elimination in 94 patients with leukemia, lymphoma, or osteosarcoma retrospectively. Results: The percentages of concomitant use of Stronger Neo-Minophagen C (SNMC), a glycyrrhizin preparation, and vincristine were higher in the delayed group. The percentage of delayed MTX elimination in patients receiving HD-MTX therapy was 41%. Multiple logistic regression analysis revealed that the concomitant use of SNMC solely was a significant risk factor for delayed MTX (odds ratio = 12.20; 95% CI = 1.06-139.84). Conclusion and Relevance: Concomitant use of SNMC was shown to be related to delayed elimination of serum MTX, and our results suggested a previously unknown drug-drug interaction between MTX and SNMC.
Trajectories of Depressive Symptoms in Adolescence: The Interplay of Maternal Emotion Regulation Difficulties and Youth ADHD Symptomatology
Authors: Oddo Lauren E. , Felton Julia W. , Meinzer Michael C. , Mazursky-Horowitz Heather , Lejuez Carl W. , Chronis-Tuscano Andrea
Published: August 2019

Objective: ADHD and depression co-occur at higher than chance levels in adolescence, but moderators of this association are not well understood. Consistent with a developmental–transactional framework, one such moderator may be maternal emotion regulation (ER) difficulties. Using latent growth curve modeling, the current study examined the independent and interactive effects of adolescent ADHD symptoms and maternal ER difficulties on the trajectory of depressive symptoms across adolescence. Method: This study included a community sample of 247 adolescents ( Mage = 13.06 years) assessed annually over a 6-year period. Results: Findings suggested that youth with greater ADHD symptoms whose mothers evidenced more ER difficulties demonstrated steeper increases in depressive symptoms over time relative to their peers with lower ADHD symptoms or whose mothers reported fewer ER difficulties. Conclusion: This work highlights the importance of maternal ER difficulties in predicting the trajectory of depressive symptoms among adolescents with ADHD symptomatology.
Gene Families, Epistasis and the Amino Acid Preferences of Protein Homologs
Authors: Ferrada Evandro
Published: August 2019

In order to preserve structure and function, proteins tend to preferentially conserve amino acids at particular sites along the sequence. Because mutations can affect structure and function, the question arises whether the preference of a protein site for a particular amino acid varies between protein homologs, and to what extent that variation depends on sequence divergence. Answering these questions can help in the development of models of sequence evolution, as well as provide insights on the dependence of the fitness effects of mutations on the genetic background of sequences, a phenomenon known as epistasis. Here, I comment on recent computational work providing a systematic analysis of the extent to which the amino acid preferences of proteins depend on the background mutations of protein homologs.
Open for change but closed for transformation: A communicative analysis of managerial corporate social responsibility discourse on the issue of labor
Authors: Ban Zhuo
Published: August 2019

Why do some researchers observe that managerial corporate social responsibility discourse contributes to increased awareness of and commitment to solving global environmental and social issues, while others reveal that the same discourse works to obfuscate and sidetrack positive social transformation? This article tries to bring together these procedural and structural perspectives on corporate social responsibility discourse by introducing a communicative approach, which embeds the critical study of corporate social responsibility discourse in a complex and emerging discursive field. The discursive strategies of managerial corporate social responsibility are therefore as shifting as the discourses it competes with are varied. This article, grounded in Deetz’s theoretical framework of systematically distorted communication and discursive closure, explores the US garment industry’s corporate social responsibility communication on labor-related issues in the global supply chain. I position garment industry corporate social responsibility discourse within broad labor policy debates at the operational, institutional, and structural levels. I find that corporate-initiated corporate social responsibility communication operates through several internally coherent frames: establishing ethical standards, providing essential services, and innovating labor management systems. Each frame responds to alternative discourses about supply chain labor with discursive closure and non-closure strategies, that is, corporations choose to acknowledge, engage, or agree with some alternative discourses, while ignoring, suppressing, or eliding over others. I argue that the pattern of choosing discursive strategies for different types of alternative discourses is important in understanding systematically distorted communication in the context of a complex, fragmented discursive field.
Understanding anxiety in adults on the autism spectrum: An investigation of its relationship with intolerance of uncertainty, sensory sensitivities and repetitive behaviours
Authors: Hwang Ye In (Jane) , Arnold Samuel , Srasuebkul Preeyaporn , Trollor Julian
Published: August 2019

Anxiety is present in high rates in both children and adults on the autism spectrum. An increasing number of studies have highlighted the potentially important role that intolerance of uncertainty may have in anxiety for those on the spectrum, as well as their interrelationships with sensory sensitivities and repetitive behaviours. In response to a lack of studies involving adults, this study examined self-report survey data regarding intolerance of uncertainty, sensory sensitivities, repetitive behaviours and anxiety in a sample of 176 adults on the autism spectrum (mean age = 42). Intolerance of uncertainty and anxiety were both found to be elevated relative to non-autistic adults ( N = 116) and significant, positive correlations were found between intolerance of uncertainty, anxiety, repetitive behaviours and sensory sensitivities in those on the spectrum. Intolerance of uncertainty was found to be a significant mediator between sensory sensitivities and anxiety, as well as between anxiety and insistence on sameness behaviours. These results were not sensitive to age. Intolerance of uncertainty is an important factor to be considered in the conceptualisation and management of elevated rates of anxiety for adults on the autism spectrum.
Descriptive Statistics From Published Research: A Readily Available Alternative to Raw Data to Assess Analytic Reproducibility and Robustness
Authors: Nimon Kim , Conley David , Bontrager Marvin , Keiffer Greggory L. , Hammack-Brown Bryn
Published: August 2019

The Problem

Meta-science literature calls for data to be made openly available so that scholars and scholar-practitioners can validate published findings, a foundational step in the reproducibility spectrum. However, access to original research data is an ongoing dilemma in various disciplines, including human resource development.

The Solution

Scholars and scholar-practitioners have the opportunity to evaluate the credibility of previous studies without access to the original raw data. The use of descriptive statistics from published research offers an alternative to assess the reproducibility and robustness of selected prior research.

The Stakeholders

In addition to validating research before applying implications for practice in the field, practitioners could benefit from working with scholars and scholar-practitioners by assessing analytic robustness and reevaluating data through a new framework to address burgeoning organizational problems, potentially saving resources. Scholars can reimagine conceptual frameworks based on advances to theory and statistical analyses capabilities. For emerging scholars, the ability to validate prior research or apply new models using the information contained in a publication can create a learning opportunity to understand statistical analyses.
Mixing It Up: How Mixed Groups of Humans and Machines Modulate Conformity
Authors: Hertz Nicholas , Shaw Tyler , de Visser Ewart J. , Wiese Eva
Published: August 2019

This study examines to what extent mixed groups of computers and humans are able to produce conformity effects in human interaction partners. Previous studies reveal that nonhuman groups can induce conformity under certain circumstances, but it is unknown to what extent mixed groups of human and nonhuman agents are able to produce similar effects. It is also unknown how varying the number of human agents per group can affect conformity. Participants were assigned to one of five groups varying in their proportion of human to nonhuman agent composition and were asked to complete a social and analytical task with the assigned group. These task types were chosen to represent tasks which humans (i.e., social task) or computers (i.e., analytical task) may be perceived as having greater expertise in, as well as roughly approximating real-world tasks humans may complete. A mixed analysis of variance (ANOVA) revealed higher rates of conformity (i.e., percentage of time participants answered in line with their group on critical trials) with the group opinion for the analytical versus the social task. In addition, there was an impact of the ratio of human to nonhuman agents per group on conformity on the social task, with higher conformity with the group opinion as the number of humans in the group increased. No such effect was observed for the analytical task. The findings suggest that mixed groups produce different levels of conformity depending on group composition and task type. Designers of systems should be aware that group composition and task type may influence compliance and should design systems accordingly.
Analysis of shear characteristics of woven fabrics and their interaction with fabric integrated structural factors
Authors: Shanbeh Mohsen , Safar Johari Majid , Zarrebini Mohammad , Barburski Marcin , Komisarczyk Agnieszka
Published: August 2019

Behavior of woven fabrics during complex deformations is most influentially affected by their shear behavior. Shear characteristics of woven fabrics can be explained by fabric shear rigidity and shear hysteresis. In this study, the effects of weft density, weft count, and fiber type on shear behavior of woven fabrics in the principal directions of fabric were statistically evaluated. Statistical methods such as multiple linear regression analysis, univariate test, and correlation analysis were also applied. The univariate test results confirmed that the weft density is the most dominant parameter that affects fabric shear properties. Multiple linear regression results point to poor shear behavior in woven fabrics with cotton weft yarns. In addition, correlation between the shear rigidity of the fabrics along principal directions with the Milasius fabric firmness factor and the fabric cover factor as integrated structural parameters was established. High correlation was found to exist among Milasius fabric firmness factor, fabric cover factor, and shear rigidity of fabrics along principal directions.
Novel Route of Synthesis of PCL-CuONPs Composites With Antimicrobial Properties
Authors: Muñoz-Escobar Antonio , Ruíz-Baltazar Álvaro de Jesús , Reyes-López Simón Yobanny
Published: August 2019

Nanoparticles of metals can be toxic to bacteria, showing biocidal activities at low concentrations. Metal, oxide, or compounds based on copper are applied like antimicrobial agents. The capacity of integration of metallic nanoparticles in polymer matrices has improved the antimicrobial behavior, resulting in the search for composites with increased bactericidal properties. A polycaprolactone (PCL) film polymer with copper oxide nanoparticles (CuONPs) was prepared. Dynamic light scattering analysis showed the sizes from 88 to 97 nm of CuONPs. Scanning electron microscopy (SEM) revealed CuONPs with semispherical shapes with diameter 35 nm. The prepared PCL-CuONPs exhibited a nanoporous structure by SEM. The antibacterial applicability of the composite was evaluated to determine the minimum inhibitory concentration in 6 different bacteria and the experimental tests were carried by disk diffusion and spectrophotometric methods. The PCL-CuONPs exhibit a considerable antibacterial effect in gram-positive bacteria in contrast to gram-negative bacteria. The preparation of PCL-CuONPs was simple, fast, and low cost for practical application as wound dressings.
Effect of phase in fast frequency measurements for sensors embedded in robotic systems
Authors: Sanchez-Lopez Juan de Dios , Murrieta-Rico Fabian N , Petranovskii Vitalii , Antúnez-García Joel , Yocupicio-Gaxiola Rosario I , Sergiyenko Oleg , Tyrsa Vera , Nieto-Hipolito Juan I , Vazquez-Briseño Mabel
Published: August 2019

The use of sensors is a primary need in robotic systems. There are sensors that generate a signal whose frequency depends on input stimulus. The application of such sensors is desirable due to their short response time, accuracy, and resolution. For proper use of these sensors, adequate frequency measurement is required. The principle of rational approximations is a method for frequency estimation that has advantages over other measurement methods. Some of them include not a fixed sampling time, insensitivity to jitter, and accuracy limited by the reference stability. Nevertheless, there are some measurement parameters with a not well-researched effect in measurement process. The objective of this work is to elucidate how the phase of input signals (measurand and reference) affects the frequency measurement process.
Feasibility Pilot Outcomes of a Mammography Decision Support and Navigation Intervention for Women With Serious Mental Illness Living in Supportive Housing Settings
Authors: Weinstein Lara , LaNoue Mariana , Hurley Katelyn , Payton Colleen , Sifri Randa , Myers Ronald
Published: August 2019

Objective: People with serious mental illness (SMI) experience significant disparities in morbidity and mortality from preventable and treatable medical conditions. Women with SMI have low mammography screening rates. SMI, poverty, and poor access to care can have a significant effect on a woman’s opportunity to learn about and discuss breast cancer screening with health care providers. This study examines the feasibility pilot outcomes of mammography decision support and patient navigation intervention (DSNI) for women with SMI living in supportive housing settings. The primary research question was: Does the DSNI increase knowledge, promote favorable attitudes, and decrease decisional conflict relating to screening mammography? Methods: We developed the intervention with the community using participatory methods. Women (n = 21) with SMI who had not undergone screening mammography in the past year participated in an educational module and decision counseling session and received patient navigation over a 6-month period. We conducted surveys and interviews at baseline and follow-ups to assess mammography decisional conflict. Results: Among study participants, 67% received a mammogram. The mammogram DSNI was feasible and acceptable to women with SMI living in supportive housing settings. From baseline to 1-month follow-up, decisional conflict decreased significantly ( P = .01). The patient navigation process resulted in 270 attempted contacts ( M = 12.86, SD = 10.61) by study staff (phone calls and emails with patient and/or case manager) and 165 navigation conversations ( M = 7.86, SD = 4.84). A barrier to navigation was phone communication, with in-person navigation being more successful. Participants reported they found the intervention helpful and made suggestions for further improvement. Conclusions: The process and outcomes evaluation support the feasibility and acceptability of the mammography DSNI. This project provides initial evidence that an intervention developed with participatory methods can improve cancer screening outcomes in supportive housing programs for people with SMI.
Eosinophilic Cholecystitis Occurred in a Patient With Refractory Eosinophilic Airway Inflammation: A Case Report
Authors: Kuwahara Toshiaki , Kobayashi Yoshiki , Yun Yasutaka , Kanda Akira , Asako Mikiya , Ueki Shigeharu , Iwai Hiroshi
Published: August 2019

Background

Eosinophilic cholecystitis (EC) is a rare condition that presents in a manner comparable to acute cholecystitis. The diagnosis is based on classical symptoms of cholecystitis with excessive eosinophilic infiltration within the gallbladder. EC has been reported alone or in combination with manifestations, such as eosinophilic gastrointestinal tract inflammation. However, association with airway inflammation in patients with EC is rare. Case Presentation: We report the case of a 65-year-old man who had refractory eosinophilic chronic rhinosinusitis with bronchial asthma. A second endoscopic sinus surgery (ESS) was performed as treatment for recurrent nasal polyps. EC occurred while inhaled corticosteroids were reduced after ESS. Pathologic examination of the excised gallbladder demonstrated submucosal infiltration with a number of eosinophils. Furthermore, immunohistostaining revealed many galectin-10-positive cells in both the gallbladder mucosa and the paranasal sinus mucosa. Galectin-10 is a major constituent of human eosinophils, also known as the Charcot–Leyden crystal protein, which has been linked with eosinophilic inflammation. Interestingly, nasal polyps were reduced without any additional treatments 1 month after the cholecystectomy.

Conclusions

We experienced a rare case wherein EC onset occurred in a patient with refractory eosinophilic airway inflammation during inhaled corticosteroid tapering. Galectin-10 might help diagnose rare cases of eosinophilic inflammation in multiple organs.
Preferential centrality – A new measure unifying urban activity, attraction and accessibility
Authors: Hellervik Alexander , Nilsson Leonard , Andersson Claes
Published: August 2019

The fact that accessibility shapes the geographic distribution of activity needs to be addressed in any long-term policy and planning for urban systems. One major problem is that current accessibility measures rely on the identification and quantification of attractions in the system. We propose that it is possible to devise a network centrality measure that bypasses this reliance and predicts the distribution of urban activity directly from the structure of the infrastructure networks over which interactions take place. From a basis of spatial interaction modelling and eigenvector centrality measures, we develop what we call a preferential centrality measure that recursively and self-consistently integrates activity, attraction and accessibility. Derived from the same logic as Google’s PageRank algorithm, we may describe its operation by drawing a parallel: Google’s PageRank algorithm ranks the importance of networked documents without the need to perform any analysis of their contents. Instead it considers the topological structure of the network and piggybacks thereby on contextualised and deep evaluation of documents by the myriad distributed agents that constructed the network. We do the same thing with regard to networked geographical zones. Our approach opens up new applications of modelling and promises to alleviate a host of recalcitrant problems, associated with integrated modelling, and the need for large volumes of socio-economic data. We present an initial validation of our proposed measure by using land taxation values in the Gothenburg municipality as an empirical proxy of urban activity. The resulting measure shows a promising correlation with the taxation values.
Seismic anelastic attenuation estimation using prestack seismic gathers
Authors: Liu Naihao , Zhang Bo , Gao Jinghuai , Wu Hao , Li Shengjun
Published: August 2019

The seismic quality factor [Formula: see text] quantifies the anelastic attenuation of seismic waves in the subsurface and can be used in assisting reservoir characterization and as an indicator of hydrocarbons. Usually, the [Formula: see text]-factor is estimated by comparing the spectrum changes of vertical seismic profiles and poststack seismic data. However, seismic processing such as the normal moveout (NMO) stretch would distort the spectrum of the seismic data. Hence, we have estimated [Formula: see text] using prestack time migration gathers. To mitigate the NMO stretch effect, we compensate the NMO stretch of prestack seismic gathers in the time-frequency domain. Similar to the log spectral method, our method obtains the [Formula: see text] by measuring the log spectral ratio (LSR) of seismic events of the top and base of the reservoir at a zero-offset seismic trace. The LSR has a linear relationship with a new parameter [Formula: see text] by assuming that the source wavelet is a constant-phase wavelet. The parameters [Formula: see text] and LSR vary with the offset value (traveltime). We use the values of [Formula: see text] and LSR obtained from nonzero-offset seismic traces to simulate the values of [Formula: see text] and LSR at a zero-offset seismic trace. Finally, we obtain [Formula: see text] by applying the classic LSR method to the simulated [Formula: see text] and LSR. To demonstrate the validity and effectiveness of our method, we first apply it to noise-free and noisy synthetic data examples and then to real seismic data acquired over the Sichuan Basin, China. The synthetic and real seismic applications demonstrate the effectiveness of our method in highlighting high anelastic-attenuation zones.
Mapping cell migrations and fates in a gastruloid model to the human primitive streak
Authors: Martyn I. , Siggia E. D. , Brivanlou A. H.
Published: August 2019

Although fate maps of early embryos exist for nearly all model organisms, a fate map of the gastrulating human embryo remains elusive. Here we use human gastruloids to piece together a rudimentary fate map for the human primitive streak (PS). This is possible because differing levels of BMP, WNT, and NODAL leads to self-organization of gastruloids into homogenous subpopulations of endoderm and mesoderm, and comparative analysis of these gastruloids, together with the fate map of the mouse embryo, allows the organization of these subpopulations along an anterior-posterior axis. We also developed a novel cell tracking technique that detected robust fate-dependent cell migrations in our gastruloids comparable to those found in the mouse embryo. Taken together, our fate map and recording of cell migrations provides a first coarse view of what the human PS may resemble in vivo.
First meiotic anaphase requires Cep55-dependent inhibitory cyclin-dependent kinase 1 phosphorylation
Authors: Zhou Chenxi , Hancock Janelle L. , Khanna Kum Kum , Homer Hayden A.
Published: August 2019

During mitosis, anaphase is triggered by anaphase-promoting complex (APC)-mediated destruction of securin and cyclin B1, which leads to inactivation of cyclin-dependent kinase 1 (Cdk1). By regulating APC activity, the mitotic spindle assembly checkpoint (SAC) therefore has robust control over anaphase timing to prevent chromosome mis-segregation. Mammalian oocytes are prone to aneuploidy, the reasons for which remain obscure. In mitosis, Cep55 is required post-anaphase for the final steps of cytokinesis. We found that Cep55-depleted mouse oocytes progress normally through early meiosis I, but that anaphase I fails as a result of persistent Cdk1 activity. Unexpectedly, Cdk1 inactivation was compromised following Cep55 depletion, despite on-time SAC silencing and intact APC-mediated proteolysis. We found that impaired Cdk1 inactivation was caused by inadequate inhibitory Cdk1 phosphorylation consequent upon failure to suppress Cdc25 phosphatase, identifying a proteolysis-independent step necessary for anaphase I. Thus, the SAC in oocytes does not exert exclusive control over anaphase I initiation, providing new insight into vulnerability to error.
Μεταμορφώσεις του μυθικού διακειμένου στην ποιητική γενιά του ’70: η Σαλώμη στην ποίηση του Γιάννη Βαρβέρη, της Αθηνάς Παπαδάκη και της Μαρίας Κυρτζάκη
Authors: Χαριτάτος Γεώργιος
Published: August 2019

Ο μύθος αποτελεί ζωογόνο συστατικό για τη λογοτεχνία και τοποθετείται στον πυρήνα της συλλογικής και πολιτισμικής μνήμης. Ως εκ τούτου, η συστηματική και ενδελεχής μελέτη των μεταμορφώσεων αρχετυπικών μορφών από την κλασική και τη βιβλική παράδοση στην ποιητική γενιά του ’70, δεν είναι τυχαία. Η προσθήκη ζωογόνων μετασχηματισμένων μυθικών στοιχείων και μορφών από την αρχαιοελληνική και τη βιβλική παράδοση αποτέλεσε έναν κομβικό κοινό τόπο για την εν λόγω ποιητική γενιά. Ειδικότερα, ο Γιάννης Βαρβέρης, με εργαλείο την ειρωνεία – βασικό στοιχείο της ποιητικής της ανατροπής – προβαίνει σε μια πλήρη ρήξη είτε με τις αρχές του χριστιανισμού είτε με την ιδιοσυστασία προσώπων που παίζουν καθοριστικό ρόλο στην Αγία Γραφή, όπως η μορφή της Σαλώμης. Αφού αναφέρονται οι σημαντικότεροι σταθμοί και μετασχηματισμοί του λογοτεχνικού μύθου της Σαλώμης από τη βιβλική παράδοση μέχρι σήμερα, επιχειρείται η ερμηνευτική προσέγγιση μέσα από μια εκ του σύνεγγυς ανάγνωση των ποιημάτων και σχολιάζεται ο τρόπος αξιοποίησης του μυθικού υλικού από συγκεκριμένους εκπροσώπους της ποιητικής γενιάς του ’70. Ως εκ τούτου, προβάλλεται η Σαλώμη όχι μόνο ως πηγή έμπνευσης, αλλά και μέσο άλλοτε ανανέωσης και άλλοτε υπονόμευσης της παράδοσης.
Ο Ν. Ι. Σαλτέλης και η μετάφραση μυθιστορημάτων
Authors: Αθήνη Στέση
Published: August 2019

Dans le cadre des théories traductologiques orientées vers la figure du traducteur, j’ai choisit d’éclairer l’identité du poète romantique mineur N.I.Saltelis en tant que traducteur des romans. Les riches péritextes de ses deux traductions, Le diable boiteux (Ermoupoli 1838) d’Alain-René Lesage et Ernest, ou Le travers du siècle (Smyrna 1841) de Gustave Drouineau, font apparaître ses attitudes et ses pratiques traductives. Dans le cas du roman de Lesage qui évoque plutôt une épreuve scolaire de traduction et qui demeure jusqu'à nos jours l'unique traduction en grec moderne de ce best-seller européen de l'époque des Lumières, Saltelis y trouve à la fois un instrument d'étaler son érudition et ses relations personnelles ainsi qu'un moyen de faire son apparition dans la sphère publique.  Par ailleurs, les liens que Saltelis tisse avec l'écrivain romantique Gustave Drouineau ainsi que sa « correspondance » avec celui-ci pourraient être inscrits dans la voie qui mènera à la "traduction littéraire".
Από τους Οφιομάχους της Κέρκυρας στους Σαλίνα της Σικελίας: ένας κόσμος πεθαίνει
Authors: Σταυροπούλου Έρη
Published: August 2019

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Associations between physical activity, sedentary behavior, and health risk behaviors among adolescents from a city in Southern Brazil
Authors: Da Silva Michael Pereira , Fontana Fabio Eduardo , Welk Gregory J. , Saint-Maurice Pedro F. , Fantineli Edmar Roberto , Bacil Eliane Denise Araújo , Campos Wagner de
Published: August 2019

This study examined the independent and combined associations of physical activity (PA) and sedentary behavior (SB) with health risk behaviors in Brazilian adolescents. Participants were 893 adolescents (454 girls) from Curitiba, Brazil. The Youth Activity Profile questionnaire evaluated PA and the Adolescent Sedentary Questionnaire evaluated SB. The Youth Risk Behavior Surveillance System (YRBS) questionnaire evaluated fruit, vegetable, alcohol, and tobacco consumption. Binary Logistic regression measured the independent and combined associations of PA and SB with risk behaviors. PA was inversely associated with low fruit (OR = 0.30; 95%CI: 0.18-0.51) and vegetable consumption (OR = 0.43; 95%CI: 0.25-0.73), and tobacco use (OR = 0.52; 95%CI: 0.29-0.89). However, PA was positively associated with mild (OR = 1.54; 95%CI: 1.08-2.19) and excessive alcohol use (OR = 1.53; 95%CI: 1.01-2.33). Higher levels of PA were associated with reduced risks of smoking and healthier eating patterns, but higher likelihood of alcohol consumption.
As guerreiras do babaçu: Mulheres quebradeiras de coco em movimento
Authors: Carvalho Andressa Veras de , Macedo João Paulo
Published: August 2019

Este estudo teve como objetivo recuperar as trajetórias de mulheres quebradeiras de coco piauienses que integram o Movimento Interestadual de Quebradeiras de Coco Babaçu (MIQCB), demarcando suas lutas cotidianas, formas de resistência e modos de organização e participação política, interseccionados com questões de gênero, raça, etnia, geração, território e demais marcadores que foram compondo seus modos de vida. As trajetórias dessas mulheres são atravessadas pelas situações de opressão, espoliação e violência às quais eram sujeitas, mas também apresentam marcantes histórias de luta e resistência que tecem seu cotidiano, em um contexto de efervescência política, favorecendo a emergência do MIQCB. A participação política das mulheres nesse movimento possibilitou o tensionamento das fronteiras entre público e privado, ao contestarem os lugares tradicionais que, historicamente, têm sido atribuídos às mulheres, como o espaço restrito da casa.