bluuebunny/crossref_metadata_2025 huggingface dataset:
”Another visitor!” – kun puhuvat koneet tulivat kotiin
Authors: Joelsson Tapani , Reunanen Markku
Published: April 2020

Artikkeli käsittelee kotitietokoneiden tuottamaa puhetta 8- ja 16-bittisten laitteiden kultakaudella, 1980-luvulla ja 1990-luvun alkupuoliskolla. Tänä ajanjaksona edulliset kotimikrot levisivät nopeasti Suomen koteihin, ja yhä useampi kansalainen päätyi tekemisiin tietokoneen kanssa.Tutkimusaineisto on kerätty kyselytutkimuksella, ja käsittely keskittyy vastaajien ensimmäisiin muistoihin puhuvista koneista sekä näiden kohtaamisten herättämistä tuntemuksista. Muistoissa kuuluvat 1980-luvun kotimikrot, näiden pelit ja kotimikroilun ympärille syntynyt harrastuskulttuuri. Luonnollisena lisänä muisteluissa esiintyvät ajanjakson elokuvat ja tv-sarjat, jotka loivat osaltaan odotuksia koneiden kyvyistä.Vastauksista nousee esiin merkkejä vahvistuneesta konesuhteesta, mutta vallitsevana piirteenä ovat puhuvan koneen luomat positiiviset kokemukset ja tulevaisuususkon vahvistuminen. Nuorten harrastajien tekemät kokeilut olivat usein odottamattomia ja kekseliäitä, mikä kertoo yhtäältä ennakkoluulottomasta suhtautumisesta tekniikkaan ja toisaalta siitä, että mitään vakiintuneita käyttökohteita puhuville kotitietokoneille ei ollut vielä edes olemassa.“Another visitor!” – When talking machines entered homesIn this article we focus on speech produced by 8- and 16-bit home computers during their "golden era", the 1980s and the beginning of the 1990s. Over this period budget-friendly home computers spread to Finnish homes, and an increasing number of citizens ended up in contact with computing.Our research material has been collected using an online survey, where we asked about first remembrances about talking machines and the feelings evoked by those encounters. The memories revolve around topics such as home computers of the time, their games and the emerging computer hobby culture. Naturally, movies and TV series of the time period, which created expectations about the capabilities of computers, are also present in the memories.The responses show some signs of a strengthened relationship with the machine, but the most predominant themes are the positive experiences created by a talking machine and the increased faith for the future. Experiments by young hobbyists were often unexpected and ingenious, which on the one hand tells about their open-minded attitude towards technology, and on the other hand about the lack of established uses for talking machines.
Сравнительная оценка безопасности и эффективности ксеноновой анестезии у пациентов пожилого и старческого возраста при спинальных нейрохирургических вмешательствах
Authors: Solenkova A.V. , Lubnin A.IU. , Konovalov N.A. , Kulikov A.S. , Ivanova O.N. , Kozlova K.A. , Martynova M.A. , Briniuk E.S.
Published: April 2020

Цель исследования оценить безопасность и эффективность методики общей ингаляционной анестезии ксеноном в сравнении с тотальной внутривенной анестезией (ТВА) пропофолом у пациентов пожилого и старческого возраста при спинальных нейрохирургических операциях. Материал и методы. Проспективное рандомизированное исследование включало 60 пациентов (средний возраст 74,611,2 года), оперируемых по поводу различной патологии позвоночника и спинного мозга. Критерии включения: больные с физическим статусом по ASA IIIIV и сопутствующей сердечно-сосудистой патологией. Все пациенты до операции имели плохие функциональные резервы (менее 4 МЕТ) вследствие основного заболевания и значительного ограничения двигательной активности. В 1-й группе больных (n30) была использована методика общей ингаляционной анестезии ксеноном, во 2-ю группу (n30) вошли пациенты, оперированные в условиях ТВА на основе пропофола. В обеих группах в качестве анальгетика применяли фентанил. Были сопоставлены показатели основных параметров гемодинамики, кислотно-основного состояния и газового состава артериальной крови, данные мониторинга глубины анестезии и периода пробуждения, неблагоприятные события и осложнения. Результаты. Проведенное исследование показало, что ксеноновая анестезия отвечает высоким требованиям безопасности у пациентов пожилого возраста. Гемодинамический профиль ингаляционной анестезии ксеноном более предпочтителен по сравнению с ТВА пропофолом. В 1-й группе не отмечено критических эпизодов интраоперационной гипотензии и аритмий в отличие от 2-й группы, где для коррекции гипотензии у 12 человек применяли инотропные препараты и вазопрессоры (допмин/норадреналин). Интраоперационный объем инфузионной терапии достоверно меньше в группе ингаляционной анестезии ксеноном по сравнению с ТВА пропофолом. Во время ингаляционной анестезии ксеноном у пожилых людей значения BIS-мониторинга показывают достаточное соответствие с клиническими признаками глубины анестезии. Значения BIS-индекса были идентичны рекомендуе- мому профилю в обеих исследуемых группах. Все пациенты в 1-й группе были экстубированы в операционной (среднее время экстубации 3,80,4 мин) и переведены в палату пробуждения. Во 2-й группе пациенты были экстубированы в операционной либо в палате пробуждения (среднее время экстубации 6,90,4 мин). Заключение. Ксеноновая анестезия является эффективной и безопасной методикой у пациентов пожилого и старческого возраста при проведении спинальных нейрохирургических оперативных вмешательств. Основные преимущества ингаляционной анестезии ксеноном стабильность гемодинамических показателей и быстрое пробуждение. Ксеноновая анестезия предпочтительнее для больных с сопутствующей кардиальной патологией.
Context-Aware Kubernetes Scheduler for Edge-native Applications on 5G
Authors: Ogbuachi Michael Chima , Reale Anna , Suskovics Péter , Kovács Benedek
Published: April 2020

This paper is an extension of work originally presented in SoftCOM 2019 [1]. The novelty of this work reside in its focused improvement of our scheduling algorithm towards its usage on a real 5G infrastructure. Industrial IoT applications are often designed to run in a distributed way on the devices and controller computers with strict service requirements for the nodes and the links between them. 5G, especially in concomitance with Edge Computing, will provide the desired level of connectivity for these setups and it will permit to host application run-time components in edge clouds. However, allocation of the edge cloud resources for Industrial IoT (IIoT) applications, is still commonly solved by rudimentary scheduling techniques (i.e. simple strategies based on CPU usage and device readiness, employing very few dynamic information). Orchestrators inherited from the cloud computing, like Kubernetes, are not satisfying to the requirements of the aforementioned applications and are not optimized for the diversity of devices which are often also limited in capacity. This design is especially slow in reacting to the environmental changes. In such circumstances, in order to provide a proper solution using these tools, we propose to take the physical, operational and network parameters (thus the full context of the IIoT application) into consideration, along with the software states and orchestrate the applications dynamically.
Narrativas y etnografías para el escenario post-ETA: una lectura de la película Gazta Zati Bat
Authors: Gaztañaga Julieta
Published: April 2020

En este trabajo realizo una lectura antropológica etnográficamente informada de la intertextualidad simbólica de la película Gazta Zati Bat. Este documental vasco estrenado en el año 2012 narra una serie de historias personales y políticas encadenadas en torno de un movimiento social que nace cinco años antes en un pequeño pueblo guipuzcoano, cuyos miembros trabajan por la autodeterminación a través de producir e incorporar contenido al “Derecho a decidir” inspirados por el modelo escocés. El artículo focaliza en la construcción de agencia política considerando la creación de un nuevo escenario soberanista pacífico y argumenta que iniciativas como esta producción cultural permiten repensar ejes analíticos acerca del conflicto vasco.
Sabrina Riva, La garra suave: representaciones de Miguel Hernández como escritor popular, Salamanca, Ediciones Universidad de Salamanca, 2017, 259 pp.
Authors: Domingo Mariano
Published: April 2020

Reseña del libro La garra suave: representaciones de Miguel Hernández como escritor popular
La ‘Llave del recuerdo’ y los anómalos relatos de metamorfosis en The Legend of Good Women de Geoffrey Chaucer
Authors: Balestrini María Cristina
Published: April 2020

The Legend of Good Women Chaucer empuja las formas literarias recibidas hacia un terreno experimental pendiente a la vez de la tradición y de sus renovados efectos. En coincidencia con otros textos del autor, se ofrece una reelaboración de historias procedentes de Ovidio a partir de una apropiación deliberadamente fragmentada que se nota particularmente en un uso anómalo de la metamorfosis como tópico narrativo. La escritura funciona en este poema como clave para acceder a una memoria compartida más que como despliegue de nueva erudición o búsqueda de verdades subyacentes.
Sklenář, Robert John, Plant of a Strange Vine. “Oratio Corrupta” and the Poetics of Senecan Tragedy, De Gruyter, Berlin/ Boston, 2017, 99 pp. ISBN: 978-3110517729.
Authors: Vizzotti Martín M.
Published: April 2020

reseña
Criaturas y creaturas: conciencia, evolucionismo e intencionalidad en la filosofía naturalista de Dennett
Authors: Colomina Juan J.
Published: April 2020

ResumenPrimero, veremos el modo en que Dennett defiende su teoría de la conciencia frente a los ataques de destacados filósofos, logrando contrastar su anti-intuicionismo con las numerosas dificultades que se le presentan a todos aquellos que conciben la conciencia de modo realista. Segundo, afrontamos la explicación del uso de la evolución llevado a cabo por Dennett para explicar el nacimiento de la mente humana. Tercero, analizamos el importante papel que el lenguaje tiene en la aparición del pensamiento y el modo en que ello permite el establecimiento de todo un entramado de simbología llamado cultura. Cuarto, nos detendremos en una matización y dos críticas al naturalismo dennettiano.Palabras clave:Daniel C. Dennett, conciencia, evolución, intencionalidadAbstractFirst, we show the Dennett’s theory of conciousness in a comparative and confrontative approach with the realistic conceptions of mind. Second, we confront the dennettian’s explanation of the human evolution. Third, we analyze the language’s rol in the appearance of thought and is implication in the culture. Fourth, we conclude with a elucidation and two critics of the dennettian naturalism.keywordsDaniel C. Dennett, conciousness, evolution, intentionality
La ética entre la justicia y el bien
Authors: Herrera Guevara Asunción
Published: April 2020

resumenLa moralidad que se exige al individuo actual sólo se dará en una sociedad liberada. Cómo conseguir ambos aspectos es el quehacer moral y político más acuciante. En este artículo dilucidaré una respuesta buscando una lógica diferente a la binaria que permita desenmascarar la distancia tajante entre cuestiones de justicia y cuestiones de la vida buena. Partiré de la necesidad de encontrar un puente entre lo cognitivo y lo ético (I). Dos serán las propuestas que nos permitan escapar de las falsas reconciliaciones entre lo justo y lo bueno (II). La primera vendrá de la mano de Kierkegaard (II.1); la segunda de la obra de Adorno (II.2).palabras clavejusticia-vida buena-contradicción-falsa alternativaAbstractWe claim to current human a morality within of an emancipated society. The moral and political work must get both requirements. This paper reviews the distance between Justice and Good Life. I will try to find a link between both moral concepts (I). The paper shows the solution to problem in two Thinker (II). The first about the Philosophy of Kierkegaard (II.1) ; the second about the Philosophy of Adorno (II.2).keys wordsjustice- good life- contradiction- wrong alternative
GUIA DE LEGISLAÇÃO TRABALHISTA PARA CLÍNICAS ODONTOLÓGICAS PARTICULARES
Authors: Ianaguivara Carolina Perpétuo , Kawamoto Waltraudi Orchulhak , Carvajal Jr. Claudio José , Kawamoto Junior Luiz Teruo
Published: April 2020

o profissional formado em odontologia não possui conhecimentos sobre legislação trabalhista e com isso há dificuldades em solucionar demandas no dia a dia. O objetivo da pesquisa é elaborar um guia simplificado de legislação trabalhista que auxilie na gestão da clínica e consultório odontológicos, de forma que o proprietário da clínica possa facilmente aplicar as diretrizes em seu empreendimento sem ter que ler extensas leis, jurisprudências, resoluções. A justificativa da pesquisa pauta-se no desconhecimento do dentista sobre lei trabalhista e as consequências disso na gestão, como por exemplo: demanda judicial trabalhista. O método compreendeu revisão bibliográfica, jurisprudencial e entrevista com a gestora de uma clínica odontológica composta de 32 (trinta e dois) dentistas que apontou as principais dúvidas desta. Com base nisso, o guia foi elaborado e validado. Os resultados evidenciaram as dúvidas dos dentistas de uma clínica e sugerem que estes não possuem conhecimentos mínimos em legislação trabalhista, sendo necessária a elaboração e uso do guia trabalhista.
OTIMIZAÇÃO DO PROCESSO DE RECEBIMENTO DE CARGAS COM UTILIZAÇÃO DE WMS INTEGRADO AO RFID TING DIGITAL: MENSAGENS ASSERTIVAS E A SUA RELAÇÃO COM A AUTO-EFICACIA
Authors: Teixeira Gisely Entringer , Silveira Karina Santos da Mota , Bueno Regis Cortez
Published: April 2020

Este artigo tem o objetivo de apresentar como a tecnologia RFID tem grande influência em processos realizados dentro do sistema WMS possibilitando que toda tecnologia alcance e deixe cada vez mais os processos de armazenagem práticos e diminuindo as possibilidades de erro em todo o processo da cadeia desde o recebimento até a distribuição. O RFID conta com o uso de (Tags e leitores) estes elementos o tornam cada vez mais simples, pois possuem grande influência uma conjunta a outra. A revisão do sistema WMS e do RFID trazem ao âmbito empresarial possibilidades de interação com o ambiente competitivo destacando suas habilidades e demonstrando ao cliente a agilidade nos serviços prestados. A identificação dos códigos de cada produto não necessita ser feita tão próximo da rádio- frequência utilizada, assim traz agilidade ao procedimento.
ANÁLISE SOBRE O IMPACTO DA ROTEIRIZAÇÃO EM UMA PIZZARIA DE ALTO FLUXO
Authors: Oliveira Laios Fraga , Santana Diego Batista , Bueno Regis Cortez
Published: April 2020

O presente estudo abordará os assuntos relacionados a roteirização e conceitos básicos de custos logísticos. O trabalho será baseado em uma pizzaria localizada na zona leste de São Paulo, no bairro de Guaianases, a qual atualmente não possui um planejamento adequado e eficiente para a gestão de suas entregas, contando apenas com análises superficiais em sistemas de GPS comuns.  Aplicando o sistema Routeasy para auxiliar na determinação das rotas, o presente estudo busca analisar se a empresa conseguiria otimizar e reduzir a quantidade de quilômetros gasta nos percursos de entrega, fator que consequentemente diminuiria os custos variáveis logísticos, ampliando margens de lucro.
O CRESCIMENTO DO PORTO DE ITAJAÍ E SUA IMPORTÂNCIA PARA O CENÁRIO BRASILEIRO: UM COMPARATIVO COM O PORTO DE SANTOS.
Authors: Pozo Hamilton , Dos Santos Joyce Felipe Passos
Published: April 2020

O Brasil encontra-se em processo de redistribuição da sua logística como forma de escoamento das movimentações de carga do Porto de Santos. De acordo com os dados emitidos através do boletim anual da Agência Nacional de Transportes Aquaviários - ANTAQ, os Portos Organizados e de Uso Privado movimentaram 375,22 milhões de toneladas em 2018, o Porto de Santos foi responsável por aproximadamente 107,50 milhões de toneladas movimentadas, representando 28,64% comparado com todo o país, sendo seguido pelo Porto de Itajaí que vem demonstrando grande potencial de produção e que movimentou um total de 109,58 milhões de toneladas, representando 15,09%. O estudo apresenta um comparativo de crescimento do Porto de Itajaí com o Porto de Santos e, sua importância para o Brasil. A pesquisa utiliza-se de dados secundários de portais oficiais e fontes de informações bibliográficas. Os resultados obtidos demonstram como o Porto de Itajaí cresceu, em termos de conteiners, o dobro do Porto de Santos.
Genotype-phenotype variability of DARS mutation - case reports of a trio of siblings
Authors: Ong Min , Willoughby Josh , Connolly Daniel , Mordekar Santosh , Study D. , Johnson Diana
Published: April 2020

Background: We describe a family with hypomyelination with brainstem and spinal cord involvement and leg spasticity (HBSL), a rare genetic condition causing motor impairment.
Case Presentation: Whole exome sequencing (DDD study) was performed on the proband who presented with motor symptoms. Sanger sequencing was done on the proband and two affected siblings to validate the result and confirm segregation of the variant with the phenotype. The phenotype and magnetic resonance imaging pattern of the siblings were compared. The index case and her two affected siblings were found to have the same compound heterozygous mutations in the DARS gene. The siblings had milder presentation than previously reported cases, continuing to walk unsupported and have not developed overt spasticity, but have mild upper motor neuron and cerebellar signs. Clinical severity and imaging findings were variable in this family.
Conclusion: We demonstrated intra-familial variability and very mild symptoms in our family with DARS-associated HBSL, widening the phenotypic spectrum of the condition. It is likely that other factors, genetic and environmental, play a role in this variability.
Surgical and nonsurgical treatment of papillary hyperplasia: A case report
Authors: Cruz Edison Andrés , Castro Morales Pedro Pablo , Garzón Rayo Herney
Published: April 2020

Dentures with dental plaque predispose recurrent hyperplasia on the palatal mucosa. Surgical procedures for the treatment of inflammatory papillary hyperplasia involve postsurgical discomfort and morbidity. This repot describes clinical and histologic aspects of a patient with severe akantolitic inflammatory papillary hyperplasia. The palatal mucosa was treated with a surgical bur with a low-speed handpiece. A new removable denture was performed and adapted. A follow-up of 4 years showed staility of health at palatal mucosa. Patient referred low discomfort and morbidity when using bur technique. Control of removable denture was critical for long-term healing and soft tissue stability.
Osteonecrosis of the jaw associated to biphosponates in Cali-Colombia
Authors: León Arcila Miguel Evelio , Valencia Carlos
Published: April 2020

Background: After more than 15 years of the first report of osteonecrosis associated with bisphosphonate (BP), still cases related to BP and other medications continue to be reported and there is an alert about the increase in the number of prescriptions. The need for both patients and students and health professionals to be familiar with medications, pathology, prevention and treatment measures has been highlighted.
Aim: To characterize patients with osteonecrosis in the maxilla associated to bisphosphonate (BRONJ), from Cali, Colombia.
Materials and Methods: A structured survey was conducted of 32 maxillofacial surgeons from the city of Cali, Colombia, where different topics related to affected patients and the development of the pathology such as age and gender of patients, type of medication, time of study were asked. administration, exposed bone, etc.
Results: Thirty-two maxillofacial surgeons answered the survey with a total of 8 cases, it was found that 6 corresponded to women and 2 to men and the age was over 44 years; 4 of the treatments were oral prescription and 4 intravenous; the majority of cases were presented in the jaw (88%) and 6 cases (75%) presented bone exposure.
Conclusions: Osteonecrosis associated with bisphosphonates is a situation that still occurs and could increase its incidence due to the increase in the number of prescriptions for osteoporosis medications, it is necessary that the patient community and health staff know More about this situation.
Efficacy of an Asynchronous Online Preparatory Chemistry Course: A Post-hoc Analysis
Authors: Eichler Jack , Henbest Grace , Mortezaei Kiana , Alvelais Teresa , Murphy Courtney
Published: April 2020

In an ongoing effort to increase student retention and success in the undergraduate general chemistry course sequence, a fully online preparatory chemistry course was developed and implemented at a large public research university. To gain insight about the efficacy of the online course, post-hoc analyses were carried out in which student performance on final exams, and performance in the subsequent general chemistry course were compared between the online cohort and a previous student cohort who completed the preparatory chemistry course in a traditional lecture format. Because the retention of less academically prepared students in STEM majors is a historical problem at the institution in which the online preparatory chemistry course was implemented, post-hoc analyses were also carried out to determine if this at-risk group demonstrated similar achievement relative to the population at large. Multiple linear regression analyses were used to compare final exam scores and general chemistry course grades between the online and in-person student cohorts, while statistically controlling for incoming student academic achievement. Results from these analyses suggest the fully online course led to increased final exam scores in the preparatory course (unstandardized B = 8.648, p < 0.001) and higher grades in the subsequent general chemistry course (unstandardized B = 0.269, p < 0.001). Notably, students from the lowest quartile of incoming academic preparation appear to have been more positively impacted by the online course experience (preparatory chemistry final exam scores: unstandardized B = 11.103, p < 0.001; general chemistry course grades: unstandardized B = 0.323, p = 0.002). These results suggest a fully online course can help improve student preparation for large populations of students, without resulting in a negative achievement gap for less academically prepared students. The structure and implementation of the online course, and the results from the post-hoc analyses will be described herein.
Discovery of Potent Covid-19 Main Protease Inhibitors Using Machine Learning Based Virtual Screening Strategy
Authors: T Muthu Kumar , K Rohini , James Nivya , V Shanthi , Karuppasamy Ramanathan
Published: April 2020

The emergence and rapid spreading of novel SARS-CoV-2 across the globe represent an imminent threat to public health. Novel antiviral therapies are urgently needed to overcome this pandemic. Given the great role of main protease of Covid-19 for virus replication, we performed drug repurposing study using recently deposited main protease structure, 6LU7. For instance, pharmacophore- and e-pharmacophore-based hypotheses such as AARRH and AARR respectively were developed using available small molecule inhibitors and utilized in the screening of DrugBank repository. Further, hierarchical docking protocol was implemented with the support of Glide algorithm. The resultant compounds were then examined for its binding free energy against main protease of Covid-19 by means of Prime-MM/GBSA algorithm. Most importantly, the resultant compounds antiviral activities were further predicted by machine learning-based model generated by AutoQSAR algorithm. Finally, the hit molecules were examined for its drug likeness and its toxicity parameters through QikProp algorithm. Overall, the present analysis yielded four potential inhibitors (DB07800, DB08573, DB03744 and DB02986) that are predicted to bind with main protease of Covid-19 better than currently used drug molecules such as N3 (co-crystallized native ligand), Lopinavir and Ritonavir.
Destabilizing the Structural Integrity of SARS-CoV2 Receptor Proteins by Curcumin Along with Hydroxychloroquine: An Insilco Approach for a Combination Therapy
Authors: Srivastava Akhileshwar , Singh Divya
Published: April 2020

Presently, an emerging disease (COVID-19) has been spreading across the world due to coronavirus (SARS-CoV2). For treatment of SARS-CoV2 infection, currently hydroxychloroquine has been suggested by researchers, but it has not been found enough effective against this virus. The present study based on in silico approaches was designed to enhance the therapeutic activities of hydroxychloroquine by using curcumin as an adjunct drug against SARS-CoV2 receptor proteins: main-protease and S1 receptor binding domain (RBD). The webserver (ANCHOR) showed the higher protein stability for both receptors with disordered score (<0.5). The molecular docking analysis revealed that the binding energy (-24.58 kcal/mol) of hydroxychloroquine was higher than curcumin (-20.47 kcal/mol) for receptor main-protease, whereas binding energy of curcumin (-38.84 kcal/mol) had greater than hydroxychloroquine (-35.87 kcal/mol) in case of S1 receptor binding domain. Therefore, this study suggested that the curcumin could be used as combination therapy along with hydroxychloroquine for disrupting the stability of SARS-CoV2 receptor proteins
Enantioenriched Quaternary α-Pentafluoroethyl Derivatives of Alkyl 1-Indanone-2-Carboxylates
Authors: Granados Albert , Balleteros Anna , Vallribera Adelina
Published: April 2020

An electrophilic enantioselective catalytic method for the a-pentafluoroethylation of alkyl 1-indanone-2-carboxylates is described. Under the use of La(OTf)3 in combination with (S,R)-indanyl-pybox ligand good results in terms of yield and enantioselectivities were achieved (up to 89% ee). The reaction proceeds under mild conditions leading to the formation of enantioenriched quaternary centers. This methodology uses an hypervalent iodine(III)-CF2CF3 reagent and mechanistic investigations are consistent with the involvement of a radical pathway.
Droplet Shape Control Using Microfluidics and Designer Biosurfactants
Authors: Gao Yuan , Zhao Chun-Xia , Sainsbury Frank
Published: April 2020

Many uses of emulsion droplets require precise control over droplet size and shape. Here we report a ‘shape-memorable’ micro-droplet formulation stabilized by a polyethylene glycol (PEG)-modified protein-surfactant, the droplets are stable against coalescence for months and can maintain non-spherical shapes for hours, depending on the surface coverage of PEGylated protein. Monodisperse droplets with aspect ratios ranging from 1.0 to 3.4 were controllably synthesized with a flow-focusing microfluidic device. Mechanical properties of the interfacial protein network were explored to elucidate the mechanism behind the droplet shape conservation phenomenon. Characterization of the protein film revealed that the presence of a PEG layer at interfaces alters the mechanical responses of the protein film, resulting in interfacial networks with improved strength. Taking advantage of the prolonged stabilization of non-spherical droplets, we demonstrate the possibility of functionalization of the droplet interface with accessible biotin moieties. The stabilization of micro-droplet shape with surface-active proteins that also serve as an anchor for integrating functional moieties, provides a tailorable interface for diverse applications.
A Chemographic Audit of Anti-Coronavirus Structure-Activity Information from Public Databases (ChEMBL)
Authors: Horvath Dragos , Orlov Alexey , Osolodkin Dmitry , Marcou Gilles , Ishmukhametov Aydar A. , Varnek Alexandre
Published: April 2020

Discovery of drugs against newly emerged pathogenic agents like the SARS-CoV-2 coronavirus (CoV) must be based on previous research against related species. Scientists need to get acquainted with and develop a global oversight over so-far tested molecules. Chemography (herein used Generative Topographic Mapping, in particular) places structures on a human-readable 2D map (obtained by dimensionality reduction of the chemical space of molecular descriptors) and is thus well suited for such an audit. The goal is to map medicinal chemistry efforts so far targeted against CoVs. This includes comparing libraries tested against various virus species/genera, predicting their polypharmacological profiles and highlighting often encountered chemotypes. Maps are challenged to provide predictive activity landscapes against viral proteins. Definition of “anti-CoV” map zones led to selection of therein residing 380 potential anti-CoV agents, out of a vast pool of 800M organic compounds.
群众文化活动的组织与策划研究
Authors: 叶 碧波
Published: April 2020

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现代测绘技术在工程测量中的应用
Authors: 陈 晓莉 , 王 明亮
Published: April 2020

在现代的建筑工程之中，工程测绘是其中极为重要的一个环节，工程测绘的准确性直接影响到后期建筑工程施工的顺利与否，为有效提升工程测绘的准确性，在测绘技术上面取得了较大的发展。本文首先对当前常用的现代测绘技术进行分析，然后结合实际的工程测量探讨现代测绘技术的应用。
现代测绘工程技术及其发展趋势分析
Authors: 李 一文 , 张 丹丹
Published: April 2020

随着经济的不断发展和对外开放力度的进一步增强，中国开始不断从国外引进先进的生产技术和管理经验，综合国力和国际竞争力得到了显著的提高。测绘行业作为建设中国社会主义现代化的重要地理信息产业得到了社会各界的高度关注，其在中国的工程建设和城市规划中都有着非常广泛的应用。本文主要分析了现代测绘工程技术的发展现状，展望了未来的发展趋势。
Redefining Immediacy for Email Satisfactory Communication: South-East Nigerian Lecturers’ Perspectives
Authors: Anumudu Chinedu Eugenia , Yasin Megat Al-Imran , Ghazali Akmar Ahmad , Alsagoff Syed Agil
Published: April 2020

Notwithstanding the empirical evidence that Nigerian academic staff utilized email as one of asynchronous virtual communications, recent studies pointed that low productivities were still witnessed by them due to email inability of giving them timely responses as viable means of communication. Therefore, this study was necessitated for redefining immediacy effects towards reaching email satisfactory communication among South-East Nigerian academic staff. Qualitative investigative study via case study was conducted towards soliciting their views on how to redefine immediacy for email satisfactory communication. The major findings of the study demonstrated that effective internet availability and affordable subscriptions, homophilous patterns of communications, content structure strategy, enhancing regularly email checking awareness, and power supply availability were the immediate remedies for achieving email satisfactory communication. The study eventually recommended that these factors should be taken into considerations by them towards attaining email satisfactory communication and in other asynchronous virtual communication mediums.
Custos atribuíveis a obesidade, hipertensão e diabetes no Sistema Único de Saúde, Brasil, 2018
Authors: Nilson Eduardo Augusto Fernandes , Andrade Rafaella da Costa Santin , Brito Daniela Aquino de , Michele Lessa de Oliveira
Published: April 2020

Objetivo. Estimar os custos atribuíveis a hipertensão arterial, diabetes e obesidade no Sistema Único de Saúde (SUS) no Brasil em 2018.

Métodos. Realizou-se uma estimativa dos custos atribuíveis a doenças crônicas não transmissíveis a partir dos riscos relativos e das prevalências populacionais de hipertensão, diabetes e obesidade, considerando custos de hospitalizações, procedimentos ambulatoriais e medicamentos distribuídos pelo SUS para tratamento dessas doenças. As informações de custo foram obtidas nos sistemas de informação em saúde disponíveis no SUS. A análise explorou os custos das doenças segundo sexo e idade na população adulta.

Resultados. Os custos totais de hipertensão, diabetes e obesidade no SUS alcançaram 3,45 bilhões de reais (R$) (IC95%: 3,15 a 3,75) em 2018, ou seja, mais de 890 milhões de dólares (US$). Desses custos, 59% foram referentes ao tratamento da hipertensão, 30% ao do diabetes e 11% ao da obesidade. No total, 72% dos custos foram com indivíduos de 30 a 69 anos de idade e 56%, com mulheres. Considerando separadamente a obesidade como fator de risco para hipertensão e diabetes, os custos atribuíveis a essa doença chegaram a R$ 1,42 bilhão (IC95%: 0,98 a 1,87), ou seja, 41% dos custos totais.

Conclusões. As estimativas dos custos atribuíveis às principais doenças crônicas associadas à alimentação inadequada evidenciam a grande carga econômica dessas doenças para o SUS. Os dados mostram a necessidade de priorizar políticas integradas e intersetoriais para a prevenção e o controle da hipertensão, do diabetes e da obesidade e podem apoiar a defesa de intervenções como medidas fiscais e regulatórias para alcançar os objetivos da Década de Ação das Nações Unidas sobre Nutrição.
COMPARATIVE LINGUISTICS: AIMS, TARGETS, DEVELOPMENT PROSPECTS
Authors: Buniiatova Izabella
Published: April 2020

This is a survey of comparative linguistics viewed as a set of the related paradigms that embrace comparative historical linguistics, aerial linguistics, linguistic typology and contrastive linguistics. The treatment of the science in question is largely based on the author’s long-standing experience deduced from research projects and from teaching it as a University professor. Placing the aforementioned paradigms under the umbrella concept “comparative linguistics” seems relevant and appropriate due to their sharing the key tool of investigation, i.e., COMPARISON, also due to their providing each other with applicable procedures and principles, as in case of two seemingly closer pairs, comparative historical and aerial areal linguistics, on the one hand, linguistic typology and contrastive linguistics, on the other hand.
MODEL OF THE CATEGORY OF STATE AS “FUZZY MULTIPLICITY”: CATEGORICAL FOCUS OF QUALITATIVITY
Authors: Shapochkina O.
Published: April 2020

The research reconstructed the category of state in the old Germanic languages (Gothic, Old Saxon, Old Icelandic, Old English, Old High German) by structuring categorical focuses within the state paradigm. In the paper it is proposed to consider the category of state in the Old Germanic languages as “fuzzy multiplicity” where the nucleus is the predicate of state, and around it concentrates the state protocategorial construction with subject-object relations of physical, emotional-psychological, mental state and state of perception which transmit different macro-states within the state situation that contains such categorical focuses as quality, opposition, divergence, convergence and mobility. The article covers the essence of the categorical focus for qualitative state category in the Old Germanic languages. In particular, it was done comparison of quantitative indicators usage in state protocategorial constructions for active state, intertiv (inactive constructions), mediopassiv, constructions with IV-class verbs with ending –nan in Gothic, constructions with copula-verbs “to be/to become” + participle II, constructions with participle II, reflexive constructions, reciprocal constructions. Comparison was done in the Gothic-Scandinavian and West-Germanic language areas, and it is based on such Old Germanic literature sources as the Gothic Bible “Wulfila”, “Beowulf”, “Heliand”, “Song of Hildebrand”, “Muspilli”, “Song of Ludwig”, “Old Norse Edda”. The methods used in the study revealed the fundamental development actualisers and similar and distinctive features of the category of state in the Old Germanic languages. The reconstruction of the category of state for the Old Germanic languages in modern aspect has been restored. The research represents new vision of existing truths and positive experience for re-thinking the given interpretations.
ENSINO DE QUÍMICA NA EDUCAÇÃO BÁSICA: DESAFIOS E CONTRIBUIÇÕES DO PIBID – IFCE CAMPUS ARACATI
Authors: Oliveira Ana Karoline Rocha De , Andrade Júlia Rodrigues Mendes de , Filgueiras Joyce de Sousa , Almeida João Paulo Guerreiro de
Published: April 2020

Tendo em vista os grandes percalços que a educação enfrenta, o presente trabalho tem como finalidade relatar os desafios do Ensino de Química e apresentar as contribuições do Programa Institucional de
Pengaruh Restrukturisasi Perusahaan Terhadap Kinerja Perusahaan
Authors: As’ari Hasim , Ahmad Pabulo Azfa Mutiara , Zaman Badrus
Published: April 2020

This study aims to empirically examine the effect of corporate restructuring on company performance. This analysis uses independent variables, namely debt restructuring, Right issue, Divestment, Acquisition, OPEX and layoffs. The dependent variable is ROA. The sample of this study is the issuer companies that restructured the companies listed on the IDX from 2010 to 2016. The samples of this study were 121 companies selected by purposive sampling method. Statistical methods use Multiple Linear Regression Analysis, by testing the statistical test hypotheses t and Test F. The results of this study conclude that debt restructuring, Right Issue (HMETD), Divestment, Acquisition, OPEX and layoffs significantly positively affect ROA.
Fixing Inequalities in Time
Authors: Bear Laura
Published: April 2020

Precarity and uncertainty are a key axis of inequality; yet these are not problems in or of time. They are experiences generated by the forms of financialised speculation that have eroded long term planning for the public good since the late 1980-90s. Key mediating institutions such as central banks and bureaucracies have been influenced by epistemes of Post-Keynesian economics that have eroded their capacity to provide us with security of livelihoods and relationships. These have their ethical foundations in Adam Smith’s accounts of moral selfhood, and we can draw on Edward Westermarck’s critical anthropological relativizing of Smith’s ethics in order to critique them. We can also deploy Westermarck’s analyses of moral emotions to push back against emerging epistemes of narrative economics and agent based modelling that are relegitimising financialised speculation within our economic institutions at present. But more significantly perhaps, we should take Westermarck’s approach into the wild of contemporary speculative practice to analyse the moral emotions of care that characterise it. This approach is illustrated though an ethnography of the precarious, uncertain waterscape of the Global Thames. Such ethnographies should lead us to demand new versions of care based on mutuality and solidarity from our public economic institutions. This is especially important in the present moment of the COVID-19 epidemic, which has re-politicised fiscal and monetary policy.Keywords: precarity, uncertainty, timescapes, financialisation, speculation, mutuality,solidarity
Pkm Inovasi Produk Olahan Jamur Tiram Di Kecamatan Kedungjajang Kabupaten Lumajang
Authors: Hidayat Zainul , Irdiana Sukma
Published: April 2020

Kabupaten Lumajang yang subur membuat budidaya jamur tiram marak berkembang di wilayah ini. Beberapa industri rumah tangga pengolah jamur tiram bermunculan, diantaranya “Dedy Jamur” dan “Hanik” menghadapi permasalahan lemahnya pengelolaan manajemen, terbatasnya kemampuan sumberdaya manusia, produk kurang berkualitas dan tidak inovatif, kesulitan mengakses permodalan. Dalam kegiatan program kemitraan masyarakat, mitra dikembangkan dalam aspek produksi unt uk meningkatkan kemampuan sumberdaya manusia dalam menghasilkan produk berkualitas dan aspek manajemen meningkatkan skill bidang pengelolaan usaha, manajemen produksi, manajemen pemasaran, manajemen keuangan sederhana dan permodalannya. Pelaksanaan kegiatan program kemitraan masyarakat mencapai target yaitu mitra (1) mampu berinovasi dan berkembang, (2) peningkatan kemampuan sumberdaya manusia dalam mengolah produk menjadi lebih inovatif, (3) mampu merencanakan produksi dengan matang, (4) mampu mengelola administrasi, (5) mempunyai strategi pemasaran yang kuat, (6) mampu mengakses permodalan, (7) pengadaan peralatan modern. Luaran dihasilkan adalah (1) produk berbahan baku jamur tiram inovatif dan berkualitas, (2) peralatan produksi modern, (3) sumberdaya manusia trampil, (4) pengelolaan manajemen usaha dan administrasi keuangan, (5) kemampuan mengakses modal. Pendampingan dan pengawasan yang intensif kepada mitra program dilakukan periodik dan tidak berhenti sampai selesainya program, oleh karena itu keaktifan tim melakukan pembinaan pada industri rumah tangga perlu dilakukan secara berkesinambungan.
Kelompok Usaha Kerupuk Beras di Desa Jombang Kecamatan Jombang Kabupaten Jember
Authors: Lestari Deni Esti
Published: April 2020

Kerupuk merupakan jenis makanan ringan yang dapat diperoleh dimana saja tempatnya baik di pedesaan maupun perkotaan. Selain sebagai bahan pelengkap makan tidak sedikit masyarakat yang menggunakan sebagai camilan atau makanan ringan untuk bersantai. Semakin banyak peminat kerupuk mempengaruhi banyak home industri kerupuk yang berkembang pesat. Salah satunya adalah Home Industry Krupuk Bu Endah. Hal ini menyebabkan pola pikir masyarakat berkembang. Menjadikan masyarakat lebih inovatif dan kreatif untuk berwirausaha dalam bidang pangan khususnya krupuk. Dengan alasan di atas penulis memilih mitra pengabdian Bu Endah untuk mengetahui lebih lanjut tentang proses produksi kerupuk.
Werteorientierung im Kontext von Techniknutzung im Alter am Beispiel des Dialoginstruments IDA
Authors: Kricheldorff Cornelia , Tonello Lucia
Published: April 2020

Der überwiegende Wunsch nach einer möglichst langen selbstständigen Lebensführung in der gewohnten Umgebung bis ins hohe Alter, bei einem gleichzeitigen Rückgang des familiären Pflegeund Unterstützungspotenzials, ist vielfach verbunden mit Erwartungen an technische Assistenzsysteme und Hilfsmittel zur Sicherung der individuellen Autonomie. Mit der Techniknutzung zur Sicherung der Selbstständigkeit und Autonomie sind allerdings Risiken verbunden, die sich auf Fragen des Datenschutzes, der Wahrung der Privatsphäre und der Achtung von ethischen Aspekten beziehen.
«Die Seele … ist ein weites Land»
Authors: Rieken  Bernd , Gelo Omar Carlo Gioacchino
Published: April 2020

Die Sonderstellung der Psychotherapiewissenschaft als selbstständiger Disziplin im Spannungsfeld zwischen nomothetischem und idiografischem Wissenschaftsverständnis wird plausibel gemacht. Dazu werden zunächst das herkömmliche mechanistische Wissenschaftsverständnis und seine Berechtigung skizziert, das, fussend auf systematischer Beobachtung und Experiment, vornehmlich durch die Kausalbeziehung von Ursache und Wirkung charakterisiert ist und geprägt wird durch das Streben nach Realismus, Objektivismus, Naturalismus und Universalismus. Demgegenüber legt das idiografische Wissenschaftsverständnis den Fokus auf den Einzelfall und seine Besonderheit, fragt aber gleichzeitig auch nach der Möglichkeit der Verallgemeinerbarkeit. Es ist charakterisiert durch Relativismus, Subjektivismus/Transaktionalismus, Konstruktivismus, aber auch Perspektivismus, der, obgleich eine vermittelnde Position beziehend, im wissenschaftlichen Diskurs nur eine untergeordnete Rolle spielt. Neben der Wirkursache finden dabei Zielursache, Ganzheit und analogischer Rationalitätstypus Anwendung. Nomothetisches und idiografisches Wissenschaftsverständnis sehen die Autoren als gleichermassen legitim an und plädieren daher für einen dialogischen Pluralismus.
Therapiebeziehung und duale Philosophie des Geistes
Authors: Basti Gianfranco
Published: April 2020

In diesem Beitrag werden Prinzipien der Therapiebeziehung umrissen, die auf einer dualen Anthropologie basieren, die typisch für den intentionalen Ansatz der Kognitionswissenschaften und sowohl der scholastischen als auch der phänomenologischen Tradition angehören. Dieser Ansatz basiert auf dem Prinzip, dass das Ich nicht objektivierbar ist und daher auf dem Prinzip, dass die Therapiebeziehung darin besteht, dem Ich seine Dynamik zurückzugeben, seine Fixierung auf ein immer unangemessenes Selbstbild, das durch die Umwelt oder das Individuum selbst hervorgerufen wird, zu vermeiden und ihm so seine konstruktive Beziehung zur Realität zurückzugeben. Die duale Anthropologie bietet auch eine physikalisch-mathematische Grundlage, die auf der Unterscheidung von Energie und Information basiert, die Lebewesen und insbesondere Menschen als «offenes» System im ständigen gegenseitigen Energieund Informationsaustausch mit der physischen und zwischenmenschlichen Umwelt definiert. Das bedeutet, dass der Geist und seine höheren Funktionen (Intellekt und Wille) nicht «im» Gehirn, sondern in die Schnittstelle zwischen dem Gehirn und seiner Umgebung verortet werden, wodurch der Begriff «Person» als ein für die intersubjektive Beziehung offenes Individuum eine Grundlage erhält, die – entgegen der modernen, schizophrenen Dualismen «Materie» und «Geist», «Physik» und «Metaphysik», «Wissenschaft» und «Humanismus» – in der Lage ist, in einer harmonischen Synthese das Beste der modernen Wissenschaft mit dem Kern der grossen metaphysischen Traditionen zu vereinen, jenseits der sukzessiven Unterscheidungen von Glaubensrichtungen und Kulturen.
Gewaltfreie Hermeneutik der Identität
Authors: Yousefi Hamid Reza
Published: April 2020

Der Beitrag begreift sich als ein Versuch, das Konzept einer gewaltfreien Hermeneutik der Identität (GHI) in Anlehnung an die Psychotherapiewissenschaft (PTW) zu entwerfen, die hier als ein systemisch-systematisches Dach der kontextuellen Psychotherapie betrachtet wird. Der Ausdruck «kontextuell» bezeichnet hierbei die Berücksichtigung aller Einbettungen der Identität innerhalb der Kulturen der Völker auf Theorien der Psychotherapie. Es werden Gefahren aufgezeigt und ein Lösungsvorschlag formuliert, um Konflikte zwischen diesen Psychotherapie-Theorien (PT) dialogisch zu bewältigen. Die GHI betrachtet Selbstkonzepte als offene Ganzheiten mit unendlichen Prädikaten. Jede Form von Universalisierung oder Absolutsetzung der eigenen oder einer bestimmten PT soll dabei vermieden werden, um den Toleranz-Dialog zwischen solchen Theorien und ihrer psychotherapeutischen Praxis zu fördern. Dadurch entsteht ein offener Diskursraum, in dem unterschiedliche Positionen mit ihren jeweils eigenen Fragestellungen und Lösungsansätzen vertreten sind. Das methodische Vorgehen ist hermeneutisch-enzyklisch ausgerichtet, um eine umfassend-verstehende Betrachtung der PT zu ermöglichen.
COMPARATIVE ANALYSIS OF RESISTING TO DIGGING FORCES EFFECTING STOCK BUCKET OF EXCAVATOR AND CYLINDRICAL BUCKET
Authors: Buryy Grigoriy , Scherbakov Vitaliy , Poteryaev Il'ya
Published: April 2020

The purpose of the work consists in the productivity increase of a single-bucket excavator at the expense of bucket shape perfection. The improved and offered bucket design will allow scooping more soil without changing hydraulic drive characteristics. This effect is achieved at the expense of the cylindrical shape of the rear wall of the bucket. There is presented a computation scheme of forces acting upon an improved bucket. The calculations of the advanced excavator bucket based on the YuMZ-6AKL tractor allowed drawing an outline of the supposed design and obtaining moment dependences of resistance on a bucket during digging upon a bucket rotation angle. The dependences of moment resistance on the bucket are formed for buckets with the capacity of 0.25m3, 0.35m3, 0.45m3, 0.55m3 and 0.65m3. The improved bucket design will allow increasing the volume of soil scooped thereby increasing productivity of single-bucket hydraulic excavators. Investigation methods – theoretical researches. The investigation results and novelty: there is offered the improved design of a bucket, a calculation circuit of forces acting upon an improved bucket. Conclusions: the advanced design of a bucket will allow scooping a larger volume of soil without changing hydraulic drive characteristics. In such a way, the productivity increase of single-bucket hydraulic excavators without changing hydraulic drive characteristic is achieved.