Abstract P1-07-04: Physical activity, weight and outcomes in patients receiving first-line chemotherapy for metastatic breast cancer: Results from CALGB 40502 (Alliance)
Authors: Ligibel JA , Huebner LJ , Rugo HS , Burstein H , Toppmeyer DL , Anders CK , Ma C , Hudis CA , Winer EP , Barry WT 
Published: February 2018

Background: Obesity and inactivity are associated with an increased risk of cancer-related and overall mortality in women with early-stage breast cancer, but there are few data in advanced breast cancer.

Methods: C40502 was a Phase III trial of first-line chemotherapy for patients with metastatic breast cancer (MBC). Participants were randomized to weekly paclitaxel, nab-paclitaxel or ixabepilone. Height and weight at the time of study enrollment were abstracted from medical records. After study activation, the protocol was amended to collect physical activity (PA) data. Participants completed the Nurses' Health Study Exercise Questionnaire, indicating the frequency, type and duration of recreational PA in which they engaged at study enrollment. Metabolic equivalent (MET)-hours of weekly PA (MET-hrs/wk) were calculated using the Ainsworth Compendium. PA was dichotomized to 0-9 or 9+ MET-hrs/wk based on data in early stage breast cancer suggesting that women who engaged in &gt; 9 MET-hrs of PA/wk had lower cancer-specific mortality. Association with clinical endpoints was evaluated using multivariate Cox proportional hazard models adjusting for treatment assignment, age, tumor hormone-receptor status, prior taxane use, disease-free interval and visceral metastases.

Results: 799 patients enrolled in C40502 between 2008 and 2011. Baseline body mass index (BMI) was available for 792 patients and PA data for 500 participants. Median follow up was 60 months. Median age was 56.7 years; 72% of patients had hormone receptor (HR)-positive cancers. Median BMI was 28.6 kg/m2 (IQR: 24.7-33.1 kg/m2). Patients engaged in a median of 3.3 MET-hrs/wk of PA (about 1 hour of moderate-intensity PA/wk) (IQR: 0.7-12.7 MET-hrs/wk). Neither BMI nor PA was significantly associated with progression-free (PFS) or overall survival (OS).

BMI and OutcomesBMI (kg/m2)N (%)PFS (months)Adj HRP valueOS (months)Adj HRP value18.5-24.9209 (26.4)10.0 (9.1-11.2)ref0.4826.1 (23.3-33.2)ref0.5425-29.9248 (31.3)9.0 (7.6-10.3)1.00 (0.83-1.22) 22.0 (20.0-25.4)1.05 (0.85-1.30) ≥30335 (42.3)8.7 (7.7-9.7)0.97 (0.81-1.17) 25.5 (23.1-29.5)0.95 (0.78-1.16) 

PA and OutcomesPA (MET-hrs/wk)N (%)PFS (months)Adj HRP valueOS (months)Adj HRP value0-9344 (68.8)7.9 (7.4-9.2)ref0.1323.6 (20.1-26.8)ref0.21&gt;9156 (31.2)9.8 (8.9-12.0)0.86 (0.71-1.05) 27.4 (22.3-35.6)0.87 (0.70-1.08) 

There was a trend toward longer PFS and OS in patients who reported PA &gt; 9 MET-hrs/wk vs 0-9 MET-hrs/wk, especially in individuals with HR+ cancers (median PFS 11.7 vs 9.2 months [adj HR = 0.84 (0.66-1.05)] and OS 34.0 vs 26.5 months [adj HR = 0.83 (0.66-1.05)] with PA &gt;9 vs 0- 9 MET-hrs/wk).

Conclusions: In some of the first data looking at the relationship between lifestyle factors and outcomes in MBC, there was no relationship between BMI and PFS or OS in patients receiving first-line chemotherapy for advanced disease. A trend toward improved PFS and OS was seen in multivariate analysis in patients who reported higher levels of PA, but results were not statistically significant and could have been influenced by other patient factors. More information is needed regarding the relationship between PA and cancer outcomes, especially in patients with HR+ cancers.

Citation Format: Ligibel JA, Huebner LJ, Rugo HS, Burstein H, Toppmeyer DL, Anders CK, Ma C, Hudis CA, Winer EP, Barry WT. Physical activity, weight and outcomes in patients receiving first-line chemotherapy for metastatic breast cancer: Results from CALGB 40502 (Alliance) [abstract]. In: Proceedings of the 2017 San Antonio Breast Cancer Symposium; 2017 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2018;78(4 Suppl):Abstract nr P1-07-04.