A longitudinal multiethnic study of biomarkers in systemic lupus erythematosus: Launching the GLADEL 2.0 Study Group
Authors: Gómez-Puerta José A , Pons-Estel Guillermo J , Quintana Rosana , Nieto Romina , Serrano Morales Rosa M , Harvey Guillermina B , Wojdyla Daniel , Scolnik Marina , Funes Soaje Carmen , Alba Moreyra Paula , Novatti Elisa , Arizpe Fernando , Berbotto Guillermo A , González Lucero Luciana , Porta Sabrina , Pérez Nicolás , Rodriguez Anabella M , Appenzeller Simone , de Oliveira e Silva Montadon Ana Carolina , Monticielo Odirlei Andre , Cavalcanti Fernando S , Machado Ribeiro Francinne , Borba Eduardo F , Torres dos Reis-Neto Edgard , Neira Oscar , Chahuán José Miguel , Mimica Milena , Aroca Martínez Gustavo , Tobón Gabriel J , Vásquez Gloria , Quintana-Lopez Gerardo , Moreno Alvarez Mario J. , Saavedra Miguel Ángel , Cristobal Mario Pérez , Fragoso-Loyo Hilda , Amezcua-Guerra Luis M , González-Bello Yelitza C , Abud-Mendoza Carlos , Esquivel-Valerio Jorge A , Duarte Margarita , Acosta Colman Isabel , Mora-Trujillo Claudia , Reátegui-Sokolova Cristina , Calvo Quiroz Armando A , Muñoz-Louis Roberto , Cairoli Ernesto , Rosas Iliana , Rebella Martín , Cardiel Mario H , García de la Torre Ignacio , Catoggio Luis J , Alarcón Graciela S , Pons-Estel Bernardo A ,   Gladel CO-authors, Pons-Estel Guillermo J. , Gómez-Puerta José A. , Pons-Estel Bernardo A. , Fernández-Ávila Diana C. , Soriano Enrique R. , Meras Nidia , Subilis Gisela , Maurelli Laura , Babini Alejandra , Gobbi Carla , Otaduy Cintia M. , Haye Salinas María , Saurit Verónica , Arturi Valeria , García Mercedes A. , Sattler María E. , Daniele Julieta A. , Constanza Bertolaccini María , Inés Bellomio Verónica , Micelli Marina , Matellán Carla , Kerzberg Eduardo , de los Ángeles Gargiulo María , Gomez Graciela N. , Pisoni Cecilia N. , Cosatti Micaela A. , Tereza Lavras Costallat Lilian , Carolina Londe Ana , de Souza Barbosa Vitalina , da Silva Nilzio A. , Aline Gasparin Andrese , Tavares Brenol Joao C. , Schmidt Fernandes Fernando , Machado Xavier Ricardo , Duarte Ângela Luzia P , Ataide Mariz Henrique , Cunha Andrade Carolina Albanez A. , Mendes Klumb Evandro , Bonfa Eloisa , Costa Seguro Luciana Parente , Neves Yuki Emily Figueiredo , de Oliveira Martins Lucas Victoria , Sato Emilia I. , Guerra Iris , Peralta Alexis , Llanos Carolina , Burgos Paula I. , Massardo Loreto , de la Hoz Lizeth , Bonfanti Andrés Cadena , Iglesias Gamarra Antonio , Egea Eduardo , Nieto-Aristizábal Ivana , Echeverri Alex , Alonso González-Naranjo Luis , Restrepo-Escobar Mauricio , López Martínez Rafael , Martínez Pérez José M. , Zúñiga Vera Andrés , Jara Luis Javier , Vera Lastra Olga L. , Sánchez-Briones Reyna Elizabeth , Portela Hernández Margarita , Martín-Nares Eduardo , Nuñez Alvarez Carlos , Silveira Luis H. , Juárez-Vicuña Yaneli , Viridiana Reyes-Pérez Itzel , García-Valladares Ignacio , Pérez-Santana Alejandra , Fandiño Marcela C. , Cuevas-Orta Enrique , Moreno-Salinas Andrea , Galarza-Delgado Dionicio A. , Losanto Jhonatan , Langjahr Patricia , Vázquez Marcos , Paats Astrid , Cieza Jorge N. , Alva Magaly , Pérez Medina Wilkerson , Ugarte-Gil Manuel F. , Gamboa-Cárdenas Rocío V. , Perich-Campos Risto A. , Zuñiga Corrales Katiuzka , Valdivia Paredes Norman , Mendoza Quispe Yannet , Ccolcca Huaman Daniel , Mimbela Caballero María , Rodríguez-Bautista Edral , Alba Feriz Rafael , Robaina Ricardo , Sánchez Andrea , Cordovilla Darwin , Vargas Andrea , Carolina Vargas Ana , Fernandez Alejandro , Henry Anthony , Perdomo Analía , Silveira Gonzalo , Danza Álvaro , Pizarrosa Carina , Carlomagno Adriana 
Published: January 2021

Introduction: After more than 20 years of sustained work, the Latin American Group for the Study of Lupus (GLADEL) has made a significant number of contributions to the field of lupus, not only in the differential role that race/ethnicity plays in its course and outcome but also in several other studies including the beneficial effects of using antimalarials in lupus patients and the development of consensus guidelines for the treatment of lupus in our region. Methods: A new generation of “Lupus Investigators” in more than 40 centers throughout Latin America has been constituted in order to continue the legacy of the investigators of the original cohort and to launch a novel study of serum and urinary biomarkers in patients with systemic lupus erythematosus. Results: So far, we have recruited 807 patients and 631 controls from 42 Latin-American centers including 339 patients with SLE without renal involvement, 202 patients with SLE with prevalent but inactive renal disease, 176 patients with prevalent and active renal disease and 90 patients with incident lupus nephritis. Conclusions: The different methodological aspects of the GLADEL 2.0 cohort are discussed in this manuscript, including the challenges and difficulties of conducting such an ambitious project.