bluuebunny/crossref_metadata_2025 huggingface dataset:
Vaccination coverage in Qatar: Benchmarking with global figures
Authors: Al-Dahshan Ayman , Hammoud Hamed , Chehab Mohamad , Osman Sherif R Omar
Published: August 2019

Introduction: Vaccination is considered one of the most successful and cost-effective public health interventions of the 20th century. In 2017, Qatar's Expanded Program of Immunization (EPI) provided vaccination services against a comprehensive list of 15 vaccine-preventable diseases. Objectives: To assess the performance of Qatar's national immunization system, identify possible gaps by determining the national vaccination coverage rates, and benchmark these rates against regional and global figures. Methods: The data utilized herein were retrieved from the vaccination coverage estimates generated by the World Health Organization and United Nations International Children's Emergency Fund. Relevant local, regional, and global vaccination coverage figures were manually extracted and then analyzed for six vaccines (DTP3, Pol3, MCV2, HepB, PCV3, and RotaC) in 2017. Percentages and proportions were compared using the Chi-squared test. Results: Vaccination coverage levels in Qatar have surpassed the optimal level of 90% for all vaccines. Compared with international figures, the national coverage exceeds the relevant benchmarks. For DTP3 and Pol3, Qatar achieved 97% coverage compared with 99% coverage in Jordan and 85% coverage globally. For MCV2, Qatar achieved 93% coverage compared with 99% coverage in Jordan and 67% coverage globally. For RotaC, Qatar achieved 97% coverage compared with 96% coverage in Jordan and 28% coverage globally. For HepB, Qatar achieved 97% coverage compared with 43% coverage globally. Conclusions: Compared with the international benchmarks of major vaccines, the vaccination coverage rates in Qatar are high. However, challenges for maintaining high coverage, such as cultural and language barriers, should be addressed.
ASMA E A TÉCNICA INALATÓRIA DO INALADOR PRESSURIZADO DOSIMETRADO ACOPLADO AO ESPAÇADOR: REVISÃO INTEGRATIVA
Authors: Fernandes Isabela Cristine Ferreira , Araújo Juliana Chaves , Chaves Ana Karolinne Menezes , Barbosa Maria Alves , Siqueira Karina Machado
Published: August 2019

Objetivo: identificar quais técnicas inalatórias do Inalador Pressurizado Dosimetrado, acoplado aoespaçador, têm sido utilizadas em pacientes com asma.Método: trata-se de revisão integrativa, realizada em janeiro de 2018, nas bases de dados USNational Library of Medicine e na Literatura Latino-Americana e do Caribe em Ciências de Saúde.Foram selecionados 14 artigos, publicados entre janeiro de 2011 e dezembro de 2017, quecontinham a descrição da sequência de passos da técnica inalatória.Resultados: os artigos, predominantemente, estudaram indivíduos com idade igual ou superiora 14 anos e justificaram a adoção dos passos da técnica inalatória em referências da literatura.Os passos indicados por cada artigo foram revisados por pares e realizou-se uma quantificaçãodaqueles mais citados, em que 15 passos foram definidos.Conclusão: a síntese do conhecimento gerado pode auxiliar profissionais de saúde no manejoadequado da asma, uma vez que traz evidências relacionadas à eficácia de cada passo.
INSTRUMENTOS DE MENSURAÇÃO RELACIONADOS AO CONHECIMENTO, ADESÃO, ATITUDE E AUTOEFICÁCIA EM DOENÇA FALCIFORME: REVISÃO INTEGRATIVA
Authors: Cecilio Sumaya Giarola , Pinto Valquíria Dos Santos , Pereira Sônia Aparecida Dos Santos , Sales Aline De Abreu Silvestre , Goulart Clarissa Fernandes , Aguiar Lilian Kelen de
Published: August 2019

Objetivo: identificar, na literatura nacional e internacional, instrumentos de mensuração existentespara medir os domínios conhecimento, autoeficácia, atitude e adesão ao tratamento no contextoda doença falciforme.Método: revisão integrativa realizada por meio da busca de artigos nos periódicos indexados nasbases de dados: CINAHL, LILACS, PubMed e WOS, de acordo com os critérios de inclusão: artigosoriginais, que utilizaram instrumentos para medir algum dos domínios pesquisados (conhecimento ouadesão ao tratamento ou autoeficácia ou atitudes da pessoa com doença falciforme, independenteda faixa etária da população alvo) dos últimos 15 anos (2003 a 2018).Resultados: foram incluídos 11 artigos dos 379 levantados, com cinco instrumentos identificados.Conclusão: Os instrumentos identificados poderão fornecer indicadores relacionados aos domíniospsicossociais e comportamentais relacionados à doença falciforme.
SISTEMAS DE CUIDADOS À SAÚDE DE PESSOAS COM INFARTO DO MIOCÁRDIO: REVISÃO DA LITERATURA
Authors: Paz Vanêssa Piccinin , Mantovani Maria De Fátima , Mercês Nen Nalú Alves das , Da Silva Ângela Taís Mattei , Souza Pollyanna Bahls de
Published: August 2019

Objetivo: identificar na literatura de enfermagem os sistemas de cuidados à saúde utilizados pelaspessoas com infarto do miocárdio.Método: revisão integrativa, realizada em cinco bases de dados, nacionais e internacionais, noperíodo de 2007 a 2017. Identificou-se 398 estudos e 13 foram analisados segundo a categorizaçãodos sistemas de cuidados à saúde (formal e informal).Resultados: verificou-se que o cuidado à saúde sofre influência de valores, crenças e normas sociais,as quais são construídas ao longo da vida e direcionam a busca pelos diferentes sistemas deatendimento durante o episódio agudo do infarto, destacando-se o sistema informal, estruturadopor meio da comunidade e da família.Conclusão: a compreensão por parte dos profissionais de enfermagem em relação aos sistemas decuidados à saúde auxilia na elaboração de ações de educação em saúde e no gerenciamento docuidado as pessoas acometidas pelo infarto do miocárdio.
INTERVENÇÕES NO MANEJO DA FADIGA E QUALIDADE DE VIDA EM PACIENTES EM QUIMIOTERAPIA: ESTUDO DE REVISÃO
Authors: Mendes Lorena Campos , Barichello Elizabeth
Published: August 2019

Objetivo: identificar na literatura as intervenções não farmacológicas utilizadas no manejo da fadigaoncológica e Qualidade de vida de pacientes com neoplasia digestiva em quimioterapia.Método: trata-se de uma revisão integrativa. Foram utilizadas as bases de dados MEDLINE,Pubmed, Scopus, CINAHL e Web of Science. Foram selecionados artigos em português, inglês eespanhol entre 2013-2018, que descreviam o uso de intervenções não farmacológicas utilizadas nafadiga oncológica e/ou Qualidade de Vida de pacientes com neoplasia digestiva em quimioterapia.Resultados: do total de 278 artigos, seis foram selecionados. Em relação ao idioma, todos estavamem inglês. Entre os ensaios clínicos, somente um pontuou cinco na Escala de Qualidade de Jadad.Os estudos trouxeram a utilização de programas de atividade física como sendo eficazes.Conclusão: a prática de atividades física foi considerada uma intervenção eficaz, já a acupunturanão apresentou resposta clínica viável no manejo da fadiga oncológica e Qualidade de Vida.
SÍNDROME DE BURNOUT ENTRE PROFISSIONAIS DE UM SERVIÇO DE ATENDIMENTO MÓVEL DE URGÊNCIA DO PARANÁ
Authors: Figueiroa Gabriela Bettoni , Peruzzo Hellen Emília , Gil Nelly Lopes Moraes , Back Ivi Ribeiro , Silva Eraldo Schunk da , Marcon Sonia Silva
Published: August 2019

Objetivo: identificar o risco para o desenvolvimento da Síndrome de Burnout em profissionais doServiço de Atendimento Móvel de Urgência (SAMU).Metodologia: estudo transversal, não probabilístico, realizado entre agosto e outubro de 2017 com101 profissionais atuantes em um SAMU do Paraná, utilizando questionário autoaplicável - MaslachBurnout Inventory. A análise de dados envolveu os testes de associação Qui-quadrado, Wilcoxone Mann-Whitney.Resultados: observa-se que o risco para desenvolvimento e manifestação da síndrome de Burnoutfoi identificado em 52 profissionais (51,9%) e foi mais frequente entre médicos e teleatendentes,indivíduos do sexo feminino, com mais de 40 anos, sem companheiro, sem filhos, que tinhamoutro vínculo empregatício e renda superior a 10 salários mínimos. Porém, só os que trabalhavamdurante o dia apresentaram risco significativamente maior (p=0,0075). Conclusão: as característicasdo processo de trabalho no SAMU geram sobrecarga aos profissionais, sendo importante aimplementação de estratégias que possam minimizar os efeitos estressores desta atuação.
EXPRESSÃO DAS TENDÊNCIAS PEDAGÓGICAS EM TESES E DISSERTAÇÕES DE UM LABORATÓRIO DE PESQUISA E TECNOLOGIA EM EDUCAÇÃO EM ENFERMAGEM E SAÚDE (1994-2017)
Authors: Maffissoni André Lucas , Sanes Marina Da Silva , Schneider Franciane , Martini Jussara Gue , Lino Monica Motta , Kempfer Silvana Silveira
Published: August 2019

Objetivo: analisar como as tendências pedagógicas se expressam nas investigações científicas doLaboratório de Pesquisa e Tecnologia em Educação em Enfermagem e Saúde, da UniversidadeFederal de Santa Catarina.Método: pesquisa qualitativa, utilizando análise documental de teses e dissertações produzidas noperíodo 1994-2017. A coleta dos dados ocorreu de março a maio de 2018. Dados tratados à luzda análise de conteúdo.Resultados: identificaram-se 106 documentos. Destes, 89 se filiam à tendência libertadora/criativa,17 se aproximam da tendência progressista e não foram evidenciados estudos exclusivamenterelacionados à tendência pedagógica convencional.Conclusões: as teses e dissertações do Laboratório de Pesquisa trabalharam a educação emenfermagem a partir de perspectiva pautada, majoritariamente, pela tendência pedagógicalibertadora/criativa. Este estudo contribui para a construção do conhecimento na enfermagempor reconhecer os pressupostos pedagógicos utilizados por pesquisadores da área, essencial paraidentificar quais posicionamentos políticos a enfermagem brasileira assume em suas investigaçõescientíficas.
DIFICULDADES INTRAESCOLARES NA EFETIVIDADE DO PROJETO DE CULTURA DE PAZ
Authors: Lopes Marina Frota , Pontes Herika Paiva , Oliveira Denise Nunes , Melo Juliana Carneiro , Ribeiro Jaime Emanuel Moreira , Frota Mirna Albuquerque
Published: August 2019

Objetivo: Investigar as dificuldades intraescolares para efetividade da cultura de paz na escola.Método: configura-se como um estudo exploratório e descritivo, com abordagem qualitativa, concretizado num estudo de caso em uma escola pública da Rede Municipal de Fortaleza-Ceará, com o grupo gestor e professores da referida escola. A coleta de dados foi de fevereiro a junho de 2015. A produção dos dados foi realizada por intermédio de entrevista semiestruturada. A análise e organização dos dados foram realizadas mediante Análise de Conteúdo.Resultado: verificou-se falha de comunicação, desgaste e desmotivação dos docentes, despreparo para realizarem atividades que contemplem a paz, assim como a ausência de parcerias municipais e governamentais.Conclusão: necessidade de capacitação dos professores e gestores para que ocorra de forma efetiva a promoção da Cultura de Paz nas escolas.
FEA of displacements and stresses
of aortic heart valve leaflets during
the opening phase
Authors: Bialas O. , Żmudzki J.
Published: August 2019

Purpose: Modelling of biomechanical behaviour of heart valve materials aids improvement
of biofunctional feature. The aim of the work was assessment of influence of material
thickness of leaflets of artificial aortic valve on displacements and stresses during opening
phase using finite element analysis (FEA).
Design/methodology/approach: The model of aortic valve was developed on the basis
of average anatomical valve shapes and dimensions. Nonlinear dynamic large displacements
analysis with assumption of isotropic linear elastic material behaviour was used in simulation
(Solidworks). The modulus of elasticity of 5.0 MPa was assumed and Poisson ratio set
to 0.45. The rigidly supported leaflets was loaded by pressure increasing in the range
0-55 mmHg in time 0.1 s. Leaflets with material thickness 0.13 and 0.15 and 0.17 mm were
analysed. The thickness was simulated with shell finite elements.
Findings: The highest stresses were observed in the areas of fixation of the leaflets near
the scaffold and were lower than dangerous value of fatigue of polyurethanes. Increasing the
thickness of valve leaflet material in the range of 40 micrometres resulted in reduction of the
valve outlet by almost 10 percent.
Research limitations/implications: The FEA was limited to the isotropic linear-elastic
behaviour of the material albeit can be used to assess leaflet deformation during dynamic load.
Practical implications: Leaflets design may be start from efficient FEA which helps
estimation of material impact on stress and fold formation which can affect local blood flow.
Originality/value: Aortic heart valve leaflet material can be initially tested in dynamic
conditions during opening phase with using FEA.
Outline of the concept of free democratic schools
Authors: Rybińska Jolanta
Published: August 2019

Abstract
This article is focused on the idea of free democratic schools, institutions of informal education, emerging as a result of a grassroot initiative. This educational phenomenon is an effect of pedagogical innovation and parents, gathering in the communities, who, as they say, want to create a place where children will have the opportunity to grow up in happiness and fulfilment. Such schools also known as quasi-schools, they are not formalised educational institutions, they do not have the school status and, thus, they remain on the edge of the education system, acting on the rights of home education. This article aims at presenting the main pedagogical concepts of such schools.
Over the last few years in Poland we have observed the creation of more than a dozen of democratic schools gathered around the European Democratic Education Community (EUDEC). These new institutions represent the idea of a new, emancipated education. The initiators of free democratic schools resign from adaptive didactic strategy characteristic of public schools towards emancipation modelled on the first democratic school founded in Summerhill. Free democratic schools prioritise students’ individual, subjective needs, such as the need of autonomy, cognitive activity, interaction with the environment, expressing their own attitudes towards the learnt concepts or cooperation in the search for knowledge.
The (un)tapped potential of outdoor education. Selected aspects of research
Authors: Parczewska Teresa
Published: August 2019

The article describes part of the research conducted on a sample of 156 teachers working in 17 primary schools in the Lublin and Wielkopolska Provinces. Among the objectives of the research project was to find about the difficulties being experienced by teachers relating to outdoor education. The problems pointed by the respondents were mostly connected with children’s safety, discipline, weather conditions, poor learning habits outside the classroom, and the lack of approval by head teachers for this form of education. About 50% of the surveyed teachers highlighted that access to high-quality training courses was being hampered, including to outdoor education. The results obtained encourage further and thorough research in this field.
Wissen, Governance, Recht.
Authors: Schuppert Gunnar Folke
Published: August 2019

This book’s point of departure is the finding that modern societies are knowledge-based societies. It is generally accepted that an efficient cognitive infrastructure is essential for them to function. A closer look reveals that this cognitive infrastructure of knowledge-based societies consists of several elements, namely the exploration of decentralised knowledge stocks, the diversity of knowledge processing, the regulation of access to knowledge resources and the task of the legal system to provide appropriate regulatory structures. In this respect, the traditional focus on the cognitive dimension of law must be extended to include the legal dimension of knowledge.
Verhaltenspflichten in Online-Welten
Authors: Seitz Florian
Published: August 2019

The increasing transfer of communication to cyberspace has made communication fundamentally less visible and detectable. The transience of the spoken word has repeatedly given way to the permanence of written communication, of whose consequences even digital natives are mostly insufficiently aware.
In this study, using the example of communication between schoolchildren, Florian Seitz examines the complex basic legal implications of this issue and, against this backdrop, develops an analytical framework from which a balanced form of regulation can emerge. By virtue of its interdisciplinary approach and by taking into account demarcation criteria developed in US law, the study presents practical suggestions as to how statements made in cyberspace can be limited effectively, without losing sight of the need to uphold the freedom of speech and to learn how to implement this law gradually.
An Unusual Presentation of Postpartum Spontaneous Coronary Artery Dissection
Authors: Alterie Jonathan , Villanueva Francis , Arekat Mohamed , Brill April
Published: August 2019

The postpartum population is one with a unique physiologic profile that predisposes these patients to rare and often life-threatening conditions. Herein, we discuss a case of a 37-year-old, multiparous female who presented to the emergency department with vague chest discomfort 14 days after delivering her sixth child via vaginal delivery. The patient was found to have elevated cardiac biomarkers and was ultimately diagnosed with pregnancy-related spontaneous coronary artery dissection (P-SCAD). This case report discusses the evaluation, pathophysiology, workup, and management of P-SCAD.
To tPA or Not to tPA: Two Medical-Legal Misadventures of Diagnosing a Cerebrovascular Accident as a Stroke Mimic
Authors: Moore Malia , Stuart Jonathan , Humphreys Alexandra , Pfaff James
Published: August 2019

We present two recent successfully litigated malpractice cases in which patients with cerebrovascular accidents were misdiagnosed as stroke mimics. The first was diagnosed as a hemiplegic migraine, which occurs in only 0.01% of the population. The second was diagnosed as a conversion disorder, which ultimately has a neurologic etiology in 4% of cases. In both cases, issues of poor patient communication and poor documentation were paramount in the legal outcome. We discuss caveats of stroke mimics, tissue plasminogen activator administration liability, and pitfalls in patient and family interactions.
Left Ventricular Regional Wall Motion Abnormality in the Setting of Acute Loperamide Overdose
Authors: Bornstein Kasha , Montrief Timothy , Anwar Parris Mehruba
Published: August 2019

Loperamide is an inexpensive, over-the-counter antidiarrheal agent with emerging reports of overdose due to its opioid properties. Although it is considered by many patients to be safe, cardiotoxicity has been reported, prompting the United States Food and Drug Administration to release a warning regarding the arrhythmogenic potential of loperamide. We present a case of a 32-year-old male presenting in acute loperamide overdose and subsequent cardiac dysrhythmia with focal wall motion abnormalities on echocardiogram. This finding has not been previously reported in the literature and is unique in this clinical presentation. We also highlight the potential mechanisms for loperamide cardiotoxicity and its challenging management.
Point-of-Care Ultrasound-Directed Evaluation of Elbow Effusion
Authors: Patitsas Peter , Davis Richard , Strony Robert
Published: August 2019

A 53-year-old male presented with pain in the right elbow that was sudden in onset and progressively worsening over approximately eight hours. The pain was exacerbated with any movement of the elbow. Of note, he had been recently admitted for robotic prostatectomy and had a prolonged hospital stay requiring a course of antibiotics. This case report details the emergency department evaluation of septic arthritis of the elbow with a focus on best practices for ultrasound- guided elbow arthrocentesis.
Beware of the Zebra: Nine-year-old with Fever
Authors: Lupez Kathryn , Allen Bryant , Fox Sean , Lewis Margaret
Published: August 2019

An otherwise healthy nine-year-old female who spoke only French presented with abdominal pain, vomiting, intermittent fevers, fatigue, and headache. She then quickly became febrile and altered requiring intubation. When treating a healthy child, the physician may initially develop a differential that includes common illnesses. Yet, as emergency medicine providers, we must be thinking about the “zebras” in order to not miss potentially deadly, curable diseases.
Detection of Type B Aortic Dissection in the Emergency Department with Point-of-Care Ultrasound
Authors: Earl-Royal Emily , Nguyen Phi , Alvarez Al’ai , Gharahbaghian Laleh
Published: August 2019

Aortic dissection (AD) is a rare, time-sensitive, and potentially fatal condition that can present with subtle signs requiring timely diagnosis and intervention. Although definitive diagnosis is most accurately made through computed tomography angiography, this can be a time-consuming study and the patient may be unstable, thus preventing the study’s completion. Chest radiography (CXR) signs of AD are classically taught yet have poor diagnostic reliability. Point-of-care ultrasound (POCUS) is increasingly used by emergency physicians for the rapid diagnosis of emergent conditions, with multiple case reports illustrating the sonographic signs of AD. We present a case of Stanford type B AD diagnosed by POCUS in the emergency department in a patient with vague symptoms, normal CXR, and without aorta dilation. A subsequent review of CXR versus sonographic signs of AD is described.
The Wrongfulness of Any Intent to Kill
Authors: Girgis Sherif ,   The National Catholic Bioethics Center
Published: August 2019

Germain Grisez’s philosophical argument for respecting human life has been developed by fellow new natural law (NNL) theorists and applied to a range of lethal actions, for its conclusion is vast: intending the death of any human being as a means or an end is wrong in itself. For some Thomists, the NNL view on killing is both lax and rigorist: They consider it lax because its narrow criterion for what is “intended” leaves out some acts, especially ones related to abortion, that the critics consider murder. And they consider the NNL view rigorist insofar as it apparently rules out the death penalty, contrary to the Thomistic tradition and perhaps even heretically. However, the most salient philosophical arguments for exceptions to the principle against intending anyone’s death are weaker than the case for any given premise of the contrary NNL argument. Nevertheless, some NNL theorists’ arguments on life are unsound, some can be defended better than they have been, and some nonphilosophical objections based on theological authority require more exploration.
COMPARISON OF BARRELING EFFECT IN COMPRESSION TESTS OF TWO KINDS OF SPECIMENS USING THE FINITE ELEMENT METHOD
Authors: LEDESMA OROZCO ELIAS RIGOBERTO , AGUILERA GOMEZ EDUARDO , PLASCENCIA MORA HECTOR , RUIZ LOPEZ ISMAEL , GOMEZ MARQUEZ DIEGO ARMANDO , REVELES ARREDONDO JUAN FRANCISCO
Published: August 2019

This paper shows a comparative study of two types of forging specimens (Rastegaev and Stauchprobe) in order to obtain stress flow curves at compressive loads with a wide range of temperature, by using a Finite Element Analysis.
The main aim is to determine which specimen shows the minimum barreling phenomena under compression at different temperature condition.
After the data were obtained, a comparative analysis leads to conclude that the Stauchprobe specimen shows better compressive performance.

Keywords: Finite Element Method; barreling; compression test; forging test.
C. S. Lewis
Authors: Rayner Samantha , Searle Alison
Published: August 2019

This essay uses unpublished archival material to explore what this reveals about the commissioning, gestation, editing, and publishing of several key works of literary criticism by C. S. Lewis: The Allegory of Love: A Study in Medieval Tradition (1936), The Oxford History of English Literature in the Sixteenth Century Excluding Drama (1954), Studies in Words (1960), and The Discarded Image (1964). Our analysis looks at a range of connecting areas, including the complex labour structures and systems of patronage which operated during the period under consideration, as well as the peer review processes, assessments of potential reading markets, the practicalities of authorial revision and typesetting, and the intersections between pedagogical practice and publishing which all these demonstrate. The materials in the archives we drew upon to conduct this research were author marketing questionnaires; book cover designs; letters between Lewis, his press editors, bibliographers, and press reviewers; and cuttings from post-publication reviews. This case study makes an important contribution to our understanding of the role played by mid-twentieth century academic publishers to the production of knowledge in the English-speaking world.
Políticas de I+D y convergencia productiva en la Unión Europea
Authors: Puig Gómez Albert
Published: August 2019

La sostenibilidad de la Unión Europea pasa por la disminución de sus divergencias estructurales. Bajo esta premisa, y teniendo en cuenta que la política de I+D es clave para avanzar en la transformación productiva de los países de la UE menos avanzados tecnológicamente, la Comisión Europea acordó con cada uno de los Estados miembros unos compromisos relativos al esfuerzo en I+D (gasto en I+D en relación con el producto interior bruto) que deberían alcanzar en el año 2020. En nuestro trabajo ponemos de manifiesto la baja probabilidad de alcanzar esos compromisos, especialmente para los países con mayores necesidades de transformación productiva, entre ellos España. Y en ese mal pronóstico desempeñan un papel clave las políticas de austeridad impuestas por la propia Comisión Europea a esos mismos países, las cuales han golpeado de manera dramática en sus presupuestos públicos de I+D. En este escenario, la UE está avanzando hacia una mayor divergencia, lo cual genera mayores dudas acerca de su propia viabilidad.
Karakteristik mataair dan penggunaan air domestik di Kecamatan Gemawang, Kabupaten Temanggung
Authors: Firizqi Febby , Irshabdillah Muhammad Ridho , Prayogo Edwin Suryo , Rahmawati Aulia Ika , Hidayatulloh Muhammad Azhar , Rosidhah Nur Amrina , Aisyah Rifqiya Nur , Astuti Bernadetta Indri Dwi , Fauzan Muhammad , Tastian Naufal Fattah , Agniy Romza Fauzan
Published: August 2019

Mataair merupakan pemusatan aliran airtanah yang keluar di permukaan. Ada beberapa faktor yang menyebabkan munculnya mataair di antaranya kontak antar formasi geologi dan perubahan tekuk lereng. Tujuan dari penelitian ini adalah a) menginventarisasi mata air yang terdapat di kecamatan Gemawang; b) menguji kualitas air pada mataair yang terdapat di kecamatan Gemawang; c) mengetahui upaya konservasi mata air yang dilakukan masyarakat dan Pemerintah Daerah Kecamatan Gemawang; d) mengetahui penggunaan kebutuhan air domestik setiap desa yang terdapat di kecamatan Gemawang. Metode yang digunakan dalam penelitian ini adalah survei lapangan untuk menginventarisasi sebaran mataair yang ada di daerah kajian dan metode wawancara guna menjawab tujuan ke-3 dan ke-4. Hasil yang diperoleh dari penelitian ini adalah a) jumlah mataair yang ditemukan di Kecamatan Gemawang berjumlah 52 mataair; b) karakteristik mataair yang diuji meliputi DHL, pH, suhu, dan debit; c) upaya konservasi sumberdaya air dapat dilakukan dengan cara meningkatkan pemanfaatan air permukaan dan airtanah, meningkatkan efisiensi air irigasi, menjaga kualitas air sesuai peruntukannya; dan d) penggunaan untuk kebutuhan domestik rumah tangga antara lain mencuci pakaian, makan/minum, mandi, siram pekarangan dan untuk mencuci motor. Kata kunci: Karakteristik, Konservasi, Kebutuhan domestik, Kecamatan Gemawang, Mataair
Pemodelan spasial distribusi karbon monoksida di kota Bandung
Authors: Arista Faza , Saraswati Ratna , Wibowo Adi
Published: August 2019

Pencemaran udara merupakan permasalahan penting yang banyak terjadi di daerah perkotaan. WHO menyatakan 91% manusia di dunia menghirup udara tidak sehat. Kota Bandung sebagai kota metropolitan terus mengalami peningkatan pertumbuhan penduduk yang menyebabkan peningkatan luas lahan terbangun dan penurunan luas area hijau. Hal ini menimbulkan permasalahan penurunan kualitas udara. Penelitian ini bertujuan menganalisis secara spasial distribusi polutan di Kota Bandung dan hubungannya dengan pola persebaran suhu permukaan daratan, kerapatan bangunan dan kerapatan vegetasi. Metode yang digunakan pada penelitian ini metode spasial berupa interpolasi IDW, LST, NDBI, dan NDVI. Uji statistik menggunakan korelasi dan regresi. Hasil penelitian menunjukkan model spasial distribusi konsentrasi CO menunjukkan pola yang tersebar hampir sama pada bulan kering 2018 yaitu pada suhu permukaan daratan dan kerapatan bangunan yang relatif tinggi serta kerapatan vegetasi yang relatif rendah maka kadar polutan tinggi. Hasil uji statistik menyatakan suhu permukaan daratan, kerapatan bangunan dan kerapatan vegetasi berkorelasi cukup kuat terhadap distribusi Karbon Monoksida dan hasil regresi menyatakan suhu permukaan daratan, kerapatan bangunan dan kerapatan vegetasi terdapat pengaruh yang signifikan terhadap distribusi Karbon Monoksida. Kata kunci: Indeks Bangunan, Indeks Vegetasi, Model Spasial, Polutan, Suhu Permukaan Daratan
Potensi wilayah terdampak keruntuhan Bendungan Matenggeng di Sungai Cijolang
Authors: Utomo Bagus Prio , Rahardjo Adam Pamudji , Legono Djoko
Published: August 2019

Abstrak. Bendungan Matenggeng yang rencana akan dibangun di Sungai Cijolang merupakan bendungan multifungsi yang memiliki banyak manfaat bagi masyarakat diantaranya untuk mengairi lahan irigasi, air baku, pengendalian banjir, pembangkit tenaga listrik, dan pariwisata. Selain memiliki banyak manfaat, pembangunan bendungan juga menyimpan potensi bahaya yang sangat tinggi. Salah satu potensi bahaya yang dapat terjadi adalah keruntuhan bendungan yang diakibatkan adanya rekahan karena limpasan air pada puncak bendungan (overtopping) ataupun rekahan karena adanya rembesan di tubuh bendung (piping). Keruntuhan Bendungan akan menimbulkan banjir bandang yang sangat besar sehingga dapat menyebabkan timbulnya korban jiwa dan kerusakan harta benda. Dengan menggunakan program HEC-RAS 5.0.3, didapatkan hasil bahwa pada skenario keruntuhan overtopping, dimensi pelimpah Bendungan Matenggeng masih mampu untuk melewatkan debit maksimum (QPMF) sebesar 9.067 m3/s sehingga air tidak sampai melimpas ke puncak bendungan. Pada skenario keruntuhan piping, diperkirakan luas genangan mencapai 17.568 ha yang akan menggenangi 92 desa, 416 km jalan, dan 169 fasilitas umum.  Lebih dari separuh luas wilayah yang tergenang masuk kategori bahaya banjir tinggi hingga ekstrim dengan lahan sawah merupakan wilayah yang paling banyak masuk dalam kategori tersebut.

 Kata kunci: genangan, kategori bahaya banjir, bendungan.

 
Multivariate stochastic volatility modeling of neural data
Authors: Phan Tung D , Wachter Jessica A , Solomon Ethan A , Kahana Michael J
Published: August 2019

Because multivariate autoregressive models have failed to adequately account for the complexity of neural signals, researchers have predominantly relied on non-parametric methods when studying the relations between brain and behavior. Using medial temporal lobe (MTL) recordings from 96 neurosurgical patients, we show that time series models with volatility described by a multivariate stochastic latent-variable process and lagged interactions between signals in different brain regions provide new insights into the dynamics of brain function. The implied volatility inferred from our process positively correlates with high-frequency spectral activity, a signal that correlates with neuronal activity. We show that volatility features derived from our model can reliably decode memory states, and that this classifier performs as well as those using spectral features. Using the directional connections between brain regions during complex cognitive process provided by the model, we uncovered perirhinal-hippocampal desynchronization in the MTL regions that is associated with successful memory encoding.
The revised complete mitogenome sequence of the tree frogPolypedatesmegacephalus(Anura, Rhacophoridae) by next-generation sequencing and phylogenetic analysis
Authors: Huang An , Liu Shuo , Li Haijun , Luo Hongdi , Ni Qingyong , Yao Yongfang , Xu Huailiang , Zeng Bo , Li Ying , Wei Zhimin , Li Song , Zhang Mingwang
Published: August 2019

The mitochondrial genome (mitogenome) sequence of the tree frogPolypedates megacephalus(16,473 bp) was previously reported as having the unusual characteristic of lacking the ND5 gene. In this study, a new mitogenome ofP. megacephalus(19,952 bp) was resequenced using the next-generation sequencing (NGS) and standard Sanger sequencing technologies. It was discovered that the ND5 gene was not lost but translocated to the control region (CR) from its canonical location between the ND4 and ND6 genes. In addition, a duplicated control region was found in the new mitogenome of this species. Conservative region identification of the ND5 gene and phylogenetic analysis confirmed that the ND5 gene was located between two control regions. The phylogenetic relationship among 20 related species of anura revealed a rearrangement of the ND5 gene during the evolutionary process. These results also highlighted the advantages of next-generation sequencing. It will not only decrease the time and cost of sequencing, but also will eliminate the errors in published mitogenome databases.
Downregulated expression of ARHGAP10 correlates with advanced stage and high Ki-67 index in breast cancer
Authors: Li Yujing , Zeng Beilei , Li Yunhai , Zhang Chong , Ren Guosheng
Published: August 2019

Background

Rho GTPase-activating protein 10 (ARHGAP10), which catalyzes the conversion of active Rho GTPase to the inactive form, is downregulated in some cancers. However, little is known about ARHGAP10 in breast cancer.

Methods

The transcriptional expression level of ARHGAP10 in breast cancer was analyzed with the data downloaded from The Cancer Genome Atlas (TCGA) and Oncomine, then verified by reverse-transcription quantitative polymerase chain reaction (RT-qPCR) in 30 pairs of breast cancer tissues and the corresponding adjacent normal tissues. ARHGAP10 protein expression was examined by immunohistochemistry (IHC) in 190 breast cancer and 30 corresponding adjacent normal breast tissue samples. The associations between ARHGAP10 expression and clinicopathological characteristics of patients were analyzed, and Kaplan–Meier Plotter was used to assess the relationship between ARHGAP10 and relapse-free survival (RFS). Different expression levels of ARHGAP10 in response to chemotherapy agents were determined by GEO2R online tool. The potential biological functions of ARHGAP10 were analyzed by Gene Set Enrichment Analysis (GSEA) using data downloaded from TCGA.

Results

ARHGAP10 mRNA and protein expression was lower in breast cancer tissues than in adjacent normal tissues. Low expression of ARHGAP10 was associated with advanced clinical TNM (cTNM) stage (pb = 0.001) and high Ki-67 index (p = 0.015). Low expression of ARHGAP10 indicated worse RFS (p = 0.0015) and a poor response to chemotherapy (p = 0.006). GSEA results showed that ARHGAP10 was involved in signaling pathways including protein export, nucleotide excision repair, base excision repair, focal adhesion, JAK-STAT pathway and the actin cytoskeleton.
Defining cognitive profiles of depressive patients using the Brief Assessment of Cognition in Affective Disorders
Authors: Chen Ruei-An , Lee Chun-Yi , Lee Yu , Hung Chi-Fa , Huang Yu-Chi , Lin Pao-Yen , Lee Sheng-Yu , Wang Liang-Jen
Published: August 2019

Background

Cognitive impairments in patients with depressive disorders have a negative impact on their daily skill functioning and quality of life. In this study, we evaluated the cognitive profiles and associated factors of patients with depressive disorders with the Brief Assessment of Cognition in Affective Disorders (BAC-A).

Methods

This cross-sectional study consisted of 75 patients with depressive disorders (56 patients with major depressive disorder (MDD) and 19 patients with depressive disorder NOS or dysthymic disorder (non-MDD)). We evaluated the participants’ cognitive functions at euthymic status using the BAC-A. The BAC-A includes six subtests derived from the Brief Assessment of Cognition in Schizophrenia (BAC-S) and Affective Processing Tests. The current severity of depressive symptoms was assessed with the 17-item Hamilton Depression Rating Scale (HAMD-17), and we recorded any psychotropic drugs being used by the patients.

Results

We observed no differences in cognitive profiles in the MDD group and non-MDD group after adjusting for educational levels, severity of depression, and psychotropic drugs. Instead, the HAMD-17 scores were negatively correlated to cognitive performance in working memory, motor speed, verbal fluency, attention and processing speed, executive function, composite score, and the six indexes of the Affective Processing Test measured by the BAC-A. A longer illness duration was associated with worse performance of four indexes of the Affective Processing Test. Furthermore, benzodiazepine use was associated with a worse performance of verbal memory, and antidepressant use was associated with better motor speed performance.

Conclusion

The current severity of depressive symptoms and psychotropic drugs being taken, not the diagnosis category, are associated with cognitive impairments in patients with depressive disorders. Clinicians should pay particular attention to managing residual depressive symptoms and prescribing adequate psychotropic drugs in order to eliminate depressive patients’ cognitive deficits.
Use of factor scores in multiple regression analysis for estimation of body weight by certain body measurements in Romanov Lambs
Authors: Tahtali Yalcin
Published: August 2019

The study investigates the solution of the multicollinearity between certain body measurements of Romanov lambs and prediction of the body weight of Romanov lambs using the thus calculated factor analysis scores and a multiple regression model. For this purpose, the body measurements (wither height (WH), croup height (CH), body length (BL), chest depth (CD), chest circumference (CC), chest width behind shoulders (CWS) and head length (HL)) and body weight (BW) of 6-month-old 50 Romanov lambs born in 2015 were used. The factor analysis scores were used to obtain the prediction equation for the relationship between the investigated traits. The analysis results showed that there was a multicollinearity between the wither and croup height traits used in the prediction equation. Moreover, the results revealed that the variables for the body measurements can be represented by two factors. These factors explained 50.89% and 22.86% of the total variance, respectively. The multicollinearity between the independent variables was eliminated with the use of the factor scores obtained with the factor analysis in the multiple regression model, and thus it was observed that better results can be obtained by using the factor analysis scores in the prediction of the body weight of 6-month-old Romanov lambs.
Indirect Doppler flow systolic blood pressure measurements taken with and without headphones in privately-owned, conscious dogs
Authors: Gill India R. , Price Joshua M. , Whittemore Jacqueline C.
Published: August 2019

Objective

The purpose of this study was to assess the effect of headphone use and covariates on indirect radial Doppler flow systolic arterial blood pressure (BP) measurements in dogs.

Methods

Between May and August 2018, 100 privately-owned dogs were enrolled. Blood pressure was measured in lateral recumbency, with and without headphones, using a randomized crossover design. The initial BP, mean of BP 2-6, weight, BCS, MCS, anxiety score, and heart rate were recorded. Mixed effects crossover analyses and Spearman rank correlation coefficients were determined.

Results

Eighty-four dogs completed the study. Eleven dogs were removed due to excessive anxiety, 10 of which were in the non-headphone first group. The number of dogs diagnosed as hypertensive did not differ between measurement types (19 vs. 18), with seven dogs categorized as hypertensive during both periods. Significant differences in BP were identified (F[1, 80] = 4.3, P = 0.04) due to higher results for measurements taken without headphones for BP 1, but not BP 2-6. Systolic BP was positively correlated with anxiety score, age, and weight.

Conclusions and Clinical Relevance

Though BP 1 was significantly higher when taken without headphones, this pattern did not persist for BP 2-6. Lack of association between BP 2-6 results and measurement type could reflect exclusion of dogs most sensitive to white coat hypertension, acclimation to technique, or improved sound quality of headphones. Given significantly higher BP 1 results and disproportionate exclusion of dogs due to anxiety when measurements first were taken without headphones, use of headphones is recommended to improve accuracy of results.
Keller-box Study on Casson Nano Fluid Flow over a Slanted Permeable Surface with Chemical Reaction
Authors: Rafique Khuram , Imran Anwar Muhammad , Misiran Masnita
Published: August 2019

In this problem, an examination of Casson Nanofluid boundary layer flow over linear slanted extending sheet by fusing the chemical reaction and heat generation impacts are under thought. Nanofluid demonstrate in this examination is developed on Buongiorno model for the thermal efficiencies of the liquid flow in the presence of Brownian movements and thermophoresis impacts. The nonlinear issue for Casson Nanofluid flow over slanted channel is displayed to ponder the heat and mass exchange wonder by considering portant flow parameters to strengthen the boundary layers. The governing nonlinear partial differential equations are decreased to nonlinear normal differential equations and afterward illustrated numerically by methods for the Keller-Box plot. An examination of the set up results in the absence of the joined impacts is performed with the accessible outcomes of Khan and Pop [1] and set up in a decent contract. Numerical and graphical outcomes are additionally exhibited in tables and graphs.
Henosepilachna vigintioctopunctata (Coleoptera: Coccinellidae: Epilachninae) Attacking Cultivated and Wild Crops in Brazil
Authors: Lana Aguiar Ronilda , Moreira Furtado Grazielle , Binda Assis Caio Henrique , Mulinário Patricia Miler , Pereira Cofler Tatiane , Mathias Holtz Anderson
Published: August 2019

Henosepilachna vigintioctopunctata was recorded on Solanum melongena L. for the first time in cultivated crops areas in Espirito Santo State, southeastern Brazil, in the first semester of 2017. In one-year research, H. vigintioctopunctata was recorded in eight host plants of the families Amaranthaceae and Solanaceae.  These new records represent a high potential  establishment of this pest in Brazil.
Structure‐guided design of immunomodulatory RNAs specifically targeting the cytoplasmic viral RNA sensor RIG‐I
Authors: Yong Hui Yee , Zheng Jie , Ho Victor Chin Yong , Nguyen Mai Trinh , Fink Katja , Griffin Patrick R. , Luo Dahai
Published: August 2019

The cytoplasmic immune sensor RIG‐I detects viral RNA and initiates an antiviral immune response upon activation. It has become a potential target for vaccination and immunotherapies. To develop the smallest but potent immunomodulatory RNA (immRNAs) species, we performed structure‐guided RNA design and used biochemical, structural, and cell‐based methods to select and characterize the immRNAs. We demonstrated that inserting guanosine at position 9 to the 10mer RNA hairpin (3p10LG9) activates RIG‐I more robustly than the parental RNA. 3p10LG9 interacts strongly with the RIG‐I helicase‐CTD RNA sensing module and disrupts the auto‐inhibitory interaction between the HEL2i and CARDs domains. We further showed that 3p10LA9 has a stronger cellular activity than 3p10LG9. Collectively, purine insertion at position 9 of the immRNA species triggered more robust activation of RIG‐1.
lncRNA‐PDPK2P promotes hepatocellular carcinoma progression through the PDK1/AKT/Caspase 3 pathway
Authors: Pan Weidong , Li Wen , Zhao Jun , Huang Zhiyi , Zhao Jingyuan , Chen Shuxian , Wang Chusi , Xue Youqiu , Huang Feng , Fang Qiannan , Wang Julie , Brand David , Zheng Song Guo
Published: August 2019

Hepatocellular carcinoma (HCC) is a malignancy with one of the worst prognoses. Long noncoding RNA (lncRNA) are emerging as an important regulator of gene expression and function, leading to the development of cancer. The aim of this study was to determine the relationship between lncRNA and HCC and to further guide clinical therapy. lncRNA in HCC and adjacent tissues were screened, and the correlation between lncRNA‐PDPK2P expression in liver tissues and the pathological characteristics and severity of HCC was assessed. The effects of PDPK2P on HCC proliferation, apoptosis, metastasis, and invasion were also systematically investigated via CCK‐8 assay, flow cytometry, scratch wound healing, and transwell assay, respectively. The relationship between PDPK2P and PDK1 was verified by RNA pull‐down, rescue experiments and western blot. lncRNA‐PDPK2P was highly expressed in HCC tissues with a distinct positive correlation between PDPK2P and PDK1, and the upregulation was clinically associated with a larger tumor embolus, low differentiation, and poor survival. Mechanistically, lncRNA‐PDPK2P interacted with PDK1 and promoted HCC progression through the PDK1/AKT/caspase 3 signaling pathway. lncRNA‐PDPK2P can promote HCC progression, suggesting it may be a clinically valuable biomarker and serve as a molecular target for the diagnosis, prognosis, and therapy of hepatocellular carcinoma.
Oxalsäuredinitril [MAK value documentation in German language, 2019]
Authors: Hartwig A. ,   MAK Commission
Published: August 2019

German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the maximum concentration at the workplace (MAK value) and the Pregnancy Risk Group of oxalonitrile [
460‐19‐5
].

There are no new data. The MAK value of 5 ml/m
3
was determined in analogy to the more toxic metabolite hydrogen cyanide. The MAK value for hydrogen cyanide of 1.9 ml/m
3
was derived from the human detoxification capacity per kg body weight with a respiratory volume of 10 m
3
. Therefore, the increased respiratory volume at the workplace has already been accounted for. The MAK value of oxalonitrile, which was set at 5 ml/m
3
to reflect the 2.5‐fold higher acute toxicity of hydrogen cyanide, can be retained. This is also the case for Peak Limitation Category II and the excursion factor of 2 because no irritation was observed in humans below 16 ml/m
3
.

There are no developmental toxicity studies. Therefore, oxalonitrile is assigned to Pregnancy Risk Group D.
Isobornylacrylat [MAK value documentation in German language, 2019]
Authors: Hartwig A. ,   MAK Commission
Published: August 2019

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has evaluated isobornyl acrylate [
5888‐33‐5
] considering its skin and respiratory sensitizing potential.

There are several cases of contact sensitization in humans and the results were clearly exposure‐related. A positive result in a local lymph node assay confirms that the substance is a skin sensitizer. Data for sensitization of the airways are not available. Isobornyl acrylate is designated with “Sh”.