bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessment of the safety, tolerability and effectiveness of first Russian generic aceclofenac in patients with undifferentiated peripheral inflammatory arthritis
Authors: Zavodovsky B. V. , Sivordova L. E. , Polyakova Yu. V. , Akhverdyan Yu. R. , Papichev E. V.
Published: June 2020

Aim. To evaluate the effectiveness and tolerability of the drug in patients with undifferentiated peripheral inflammatory arthritis (UPIA).
Materials and methods. We observed 60 patients (39 women and 21 men) met G. Hazlewood et al., UPIA criteria, 2011. Patients were divided into 3 groups: with monoarthritis, oligoarthritis and polyarthritis. They took aceclofenac 100 mg twice day for 3 weeks.
Results. We noted significant decreasing in pain level according to visual analogue scale: in patients with monoarthritis by 69.3 mm (p0.001); in oligoarthritis group by 47.5 mm (p0.001), in patients with polyarthritis by 30 mm (p0.001). The life quality by the EQ-5D-5L index was improved too in all groups from 0.616 to 0.829 (p0.001). The satisfaction with the therapy was: in monoarthritis patients (80% of patients and 93% of doctors noted good results), in oligoarthritis group (53% and 39% accordingly) and polyarthritis (74% and 64% respectively). We suppose the difference was due to the fact that mono- and oligoarthritis patients suffered from initial forms of seronegative spondylarthropathy, in which the effectiveness of NSAIDs is traditionally higher; polyarthritis patients probably had debut of rheumatoid arthritis. Adverse events of therapy were mild. We noted gastrointestinal tract symptoms (dyspepsia) and increased ALT in 10 patients and increased blood pressure in 1 patient. The symptoms did not require discontinuation of therapy.
Сonclusion. Post-registration observational study of first Russian generic aceclofenac (Alental, Vertex, Russia) was conducted. In UPIA patients aceclofenac therapy was most effective in mono- and oligoarthritis patients. The first Russian generic aceclofenac (Alental, Vertex, Russia) has good efficacy, tolerability and safety and can be recommended for arthritis treatment.
Comparative analysis of ovarian reserve in women with obesity in reproductive period
Authors: Grigoryan O R , Mikheev R K , Andreeva E N , Dedov I I
Published: June 2020

Objective. To evaluate the ovarian reserve function in female patients with obesity in comparison with women without obesity. Materials and methods. This study evaluated 500 caucasian women, age 20-30 years, 250 with obesity (body mass index, BMI ≥30 kg/m2) and 250 without obesity (BMI
The first experience of non-interferon therapy of HCV infection in patients with Wilson-Konovalov’s disease
Authors: Rozina T P , Ignatova T M , Fastovets S V , Starostina E E , Samokhodskaia L M , Krasnova T N
Published: June 2020

In the article we present three clinical observations demonstrating that HCV infection in patients with remission of Wilson disease causes an recrudescence of the disease, in one of the observations - decompensation of liver cirrhosis. In this study we first describe on the successful treatment of HCV infection with direct antiviral drugs in patients with Wilson disease. Establishment of all factors of liver damage and successful treatment (elimination of the virus, adequate lifelong medical treatment) allow to expect a favorable prognosis in patients with a combination of Wilson disease and HCV infection.
Coping with being cooped up: Social distancing during COVID-19 among 60+ in the United States
Authors: Emerson Kerstin Gerst
Published: June 2020

Objectives. This study examined the impact of sheltering in place and social distancing among adults aged 60 and older during the 2020 outbreak of COVID-19 in the United States.

Methods. Using convenience sampling respondents were asked to complete a web-administered survey to explore impact of social distancing on loneliness, stress, and behavioral changes. The analytic sample consisted of 833 responses of persons aged 60 and older.

Results. A large portion reported being stressed (36%), and/or being lonely (42.5%). Nearly 1/3 stated that their sense of loneliness increased during the time of social distancing. Respondents reported engaging in more solitary activity (and fewer in-person activities), using email and text messages more than usual, and spending more time on computers/tablet than usual. Approximately 2/3 reported using more social media than usual. These differed significantly by younger (age 60-70) and older (71+) respondents. Additionally, changes in physical activity, drinking, recreational drug use and sleeping pattern changes differed by age.

Conclusions. Social distancing has significant consequences on loneliness and health behaviors among adults in the United States, many of which differ by age group. Results have implications for continued shelter in place practices, but also for any older adult that may be homebound for other reasons.
Nothing to See Here? The Extension of Parent Company Liability in James Hardie Industries plc v White
Authors: White Tom
Published: June 2020

In James Hardie Industries plc v White, the New Zealand Court of Appeal considered circumstances where a parent company could be directly liable for defective products produced by its subsidiary while upholding the principles behind separate corporate personality. The Court passed off the case as an unexceptional development in the law, based on an application of ordinary tort law principles and supported by decisions from overseas jurisdictions. However, the Court neglected to consider the underlying policies of the cases it cited, ignored important distinctions between them and the present case and did not inquire into whether they were in fact relevantly applicable. In fact, the Court extended parent company liability for the acts and omissions of its subsidiary far beyond what courts in overseas jurisdictions have held. In doing so, the Court implicitly lifted the corporate veil and failed to acknowledge the impact such a finding of liability would have on the corporate form.
An Interpretation of E.M.Forster’s Novels from the Perspective of Ecofeminism
Authors: Jiang Dongyan
Published: June 2020

This paper probes into the view that how men, women and nature interact with each other in E.M.Forster’s novels from the perspective of ecofeminism. It analyzes the oppression of women and subjugation of nature in the patriarchal ideology in Forster’s works and summarizes the best to get rid of this phenomenon is by their mutual efforts, women and nature can eventually earn respect from men and establish a harmonious relationship among men, women and nature.
DEVELOPMENT OF STUDENT WORKSHEET BASED PQ4R ON CHEMICAL BOND MATERIALS CLASS X HIGH SCHOOL
Authors: Andaeri Poppy , Noer Asmadi M , Linda Roza
Published: June 2020

The purpose of this study is to develop PQ4R-based LKPD in high school chemistry learning subject to valid chemical bonds based on aspects of content eligibility, PQ4R characteristics, linguistic, presentation and graphic as well as knowing user responses to LKPD. This type of research is development research with the development process referring to the development of the Plomp model. Consists of the initial investigation, design, realization / construction, test, evaluation and revision, and implementation phases. However, this research is limited only to the test, evaluation and revision phases because the purpose of this study is to develop the product and determine the user's response. The object of this research is PQ4R-based LKPD. Data collection instruments are validation sheets and user responses. The results of the data analysis obtained validity on the aspects of content eligibility, PQ4R characteristics, linguistic, presentation and graphic characteristics, respectively; 97.62%, 95.24%, 91.67%, 95.24%, and 91.67% with valid categories. Trial of user responses by teachers and students in a row; 95.83% and 91.63%, so the LKPD that has been developed is suitable for use in the learning process.
Design and Development of Tourism Geographical Information System of Semarang City Based On Android Mobile
Authors: Shobirin Achmad , Aryotejo Guruh , Danang Danang
Published: June 2020

The development of information technology that exists today is very rapid, making us to keep abreast of the development of these technologies. Technology is able to present all information quickly and instantly, leaving old patterns such as gathering information manually which may require more time. Information technology today is very effective and efficient as indicated by the speed of processing time and the accuracy of the information needed. One of them is the information about tourist attractions, which is currently increasingly in demand by people who want to vacation with friends, relatives and family. However, the lack of information about the location of attractions that want to be visited, especially for potential tourists from outside the area of Semarang, make the author interested in design and creating the Semarang City Geographic Tourism Information System Based on Android Mobile to facilitate the search for the nearest route to the desired tourist attraction. The method used is using the Geographic Information System based on the data from the Semarang City Culture and Tourism Service. The Semarang City Tourism Geographic Information System Based on Android Mobile is a solution to problem solving as a medium to obtain information and tourism locations in the Semarang, which is applied in Android Smartphone devices, especially for the people from outside the city of Semarang.
LEGAL MODELS OF ADMINISTRATIVE PROCEDURE: EXPERIENCE OF THE EAEU COUNTRIES
Authors: Saranchuk Yuriy
Published: June 2020

On the basis of comparative legal analysis, conceptual approaches to the for-mation of the subject area and basic categories of legislation on administrative procedures in the EAEU member States are considered.
La autoría comunitaria como estrategia para tejer redes alternativas a las del orden hegemónico
Authors: Valente Claudia
Published: June 2020

El sistema de la naturaleza evoluciona de manera simultánea al sistema político de los humanos, y en el devenir genera modelos sistémicos alternativos. Estudiar las conductas naturales situadas habilita un modo de territorializar la práctica artística y producir en autoría comunitaria. Para entender este modo de producción, se presenta el proyecto “Herbario silvestre de América del sur en tiempos de neoliberalismo”, en el que se deconstruyen los procesos de los elementos para entender su estructura, la organización de la colaboración transdisciplinar y el enraizamiento territorial, y se estudia cómo los formatos comunitarios presentan sistemas complejos cuyos nodos pueden situarse en un territorio y adaptarse al fluir de las construcciones ideológicas.
El derecho humano al asilo ante la securitización de la migración en México
Authors: Coporo Quintana Gonzalo , Morales Gómez Silvia María
Published: June 2020

En este artículo se realiza un análisis sociojurídico sobre el asilo y la creciente ambigüedad que esta figura ha adquirido en la histórica tradición solidaria de México hacía las personas migrantes con necesidad de protección internacional. Se efectúa un balance geopolítico sobre la política migratoria de Estados Unidos y México, se contrasta con la evolución del asilo en la normatividad jurídica del sistema universal de derechos humanos y del sistema interamericano, y se relaciona con la normatividad mexicana. Con base en ello se concluye que la figura del asilo debe redefinirse en México y debe otorgársele un mayor alcance en el contexto actual de movilidad humana para considerarlo como un derecho humano, tal como ocurre con otras figuras de protección internacional como el refugio y la protección complementaria.
İlyasbey Camisi’nin Yapısal Davranışının Çevresel Titreşim Testi ve Sonlu Eleman Yöntemleriyle İncelenmesi
Authors: TÜRKER Temel , YANIK Yusuf
Published: June 2020

Kültürel mirasımızın önemli bir parçası olan camiler zaman içinde doğal afetler veya çeşitli sebepler neticesinde hasarlara maruz kalmaktadır. Bu nedenle camiler, zaman zaman restore edilmekte ve korunmaktadır. Tarihi yapıları korumak için mevcut yapısal davranışlarının çok iyi bilinmesi ve değerlendirilmesi gerekmektedir. Yapısal davranışları belirlemek için camilerin dinamik karakteristikleri belirlenmelidir. Bu çalışmada, İlyasbey Camisi’nin çevresel titreşim testi, üç boyutlu Sonlu eleman modeli oluşturma, model kalibrasyonu ve sabit yük, rüzgâr yükü ve deprem yükü etkileri altında analizleri incelenmiştir. Dinamik ölçümleri çevresel titreşimler altında Çevresel Titreşim Testi Yöntemiyle, analitik ölçümleri ise Sonlu Eleman Yöntemiyle gerçekleştirilmiştir. İlyasbey Camisi’nin başlangıç Sonlu Eleman modeli, cami üzerinde gerçekleştirilen çevresel titreşim testi sonuçlarına göre kalibre edilmiş ve statik ve deprem yükleri etkisindeki analizleri değerlendirilmiştir. Bu çalışmada, İlyasbey Camisi için sabit yük, rüzgâr yükü ve deprem yükü etkileri altında gerçekleştirilen analizlerden, minarede oluşan yerdeğiştirmeler ile çekme, basınç ve kayma gerilmelerinin dağılımları elde edilmiştir.
IMPLEMENTASI JAMINAN KESEHATAN NASIONAL (JKN) DI KABUPATEN BUOL
Authors: Lamadang Saharudin Is , Razak Amran , Ruseng Syamsiar
Published: June 2020

Pemerintah bertanggung jawab atas pelaksanaan jaminan kesehatan masyarakat melalui sistem Jaminan SosialNasional dengan sasaran masyarakat Penerima Bantuan Iuran.Tujuan penelitian ini mengkaji ImplementasiJaminan Kesehatan Nasional di Kabupaten Buol.Rancangan penelitian yang digunakan penelitian kualitatifpendekatan studi kasus dengan desain kasus tunggal menggunakan teori Implementasi, data diperoleh melaluiinforman dengan prosedur Purposive sampling yang berada di Dinas Kesehatan, BPJS, Dinas Sosial, Kepala Desa,Kepala Puskesmas dan staf serta masyarakat sebagai sasaran Jaminan Kesehatan Nasional, teknik pengumpulan datadengan dokumen, wawancara serta observasi. Regulasi yang telah dibuat namun tujuan regulasi belum tercapai,perbedaan data kepesertaan, kriteria dalam menentukan kepesertaan, Kurangnya tenaga kesehatan di puskesmasmasih menjadi kendala utama dalam proses Implementasi. Komunikasi, koordinasi dan sosialisasi, karateristikorganisasi yang berbeda sala satu penghambat proses implementasi sehingga Luaran Kinerja Implementasimasih menyimpang dari masyarakat yang bukan menjadi sasaran Penerima Bantuan Iuran Jaminan KesehatanNasional.
Pemberdayaan Masyarakat Melalui Program Gebrak Pakumis (Gerakan Bersama Rakyat Atasi Kawasan Padat Kumuh Miskin) Di Kecamatan Balaraja-Kabupaten Tangerang
Authors: Sulaeha Siti , Sukendar Sukendar
Published: June 2020

Permasalahan yang dihadapi oleh masyarakat sebagai mitra adalah Anggaran dana yang diberikan dari program GEBRAK PAKUMIS masih minim, Kurang melakukan pendampingan pada pelaksanaan Program Gebrak Pakumis, Belum dapat dirasakan secara merata oleh seluruh masyarakat, Akses jalan menuju lokasi penerima manfaat program yang terkadang sulit untuk ditempuh dalam melakukan proses kegiatan. Dari permasalahan tersebut di atas, maka dilakukan kegiatan workshop dan pendampingan kepada masyarakat mengenai sosialisasi penyusunan dan perencanaan program. Metode yang digunakan melalui beberapa tahap yaitu penyampaian materi kepada warga masyarakat sebagai peserta, kemudian dilanjutkan dengan tahap pendampingan dilanjutkan. Hasil dari kegiatan ini muncul keinginan masyarakat untuk lebih aktif meningkatkan kemampuannya agar pelaksanaan program berjalan dengan efektif dan efisien

Kata kunci : Program, Gebrak Pakumis
Drug-Induced Heart Failure (Part 2: Mechanisms of Development, Clinical Signs, Differential Diagnosis, Risk Factors, Treatment and Prevention)
Authors: Ostroumova O. D. , Goloborodova I. V.
Published: June 2020

Heart failure is a complex clinical syndrome caused by an impaired pumping function of the heart muscle, etiologically associated with cardiovascular disease and, in the vast majority of cases, requiring complex therapeutic regimens and simultaneous prescription of several drugs. To date, we know several classes of drugs (including those used for heart failure) which can induce development/progression of heart failure in both patients with left ventricular dysfunction, and in patients who do not have cardiovascular diseases. The aim of the study was to analyse and systematize data on development mechanisms, as well as methods of prevention and treatment of drug-induced heart failure when using diff erent groups of drugs. It has been established that drug-induced heart failure is most often associated with the use of calcium channel blockers (verapamil, diltiazem, nifedipine), beta-blockers, antiarrhythmic drugs (disopyramide, fl ecainide, propafenone, amiodarone, ibutilide, dofetilide, dronedarone), anthracyclines (doxorubicin) and other antitumor drugs (trastuzumab, bevacizumab, infl iximab), hypoglycemic drugs (thiazolidinediones, saxagliptin, alogliptin), and nonsteroidal anti-infl ammatory drugs, including selective cyclooxygenase-2 inhibitors. The study revealed various mechanisms of heart failure development following drug treatment. In some patients, heart failure development is associated with the cardiotoxic eff ect of a particular drug, in others with adverse eff ects on hemodynamics. Much depends on risks of developing heart failure, including specifi c risks attributable to groups of drugs and individual drugs. The identifi cation of drugs that can contribute to the development/ progression of heart failure, and possible clinical manifestations of drug-induced heart failure, as well as provision of timely information to physicians, and engagement of clinical pharmacologists with the aim of optimizing treatment of patients can facilitate timely diagnosis, treatment and prevention of drug-induced heart failure.
Mycobiota in Mycobiota in the grain of the oat breeding lines produced in 2019 in competitive variety trials on the fields of Nemchinovka Federal Research Center, Moscow Provincepetitive variety trials on the fields of Nemchinovka Federal Research Center, Moscow Province
Authors: Gavrilova O. P. , Gagkaeva T. Yu. , Orina A. S. , Markova A. S. , Kabashov A. D. , Loskutov I. G.
Published: June 2020

Background. The requirement for high-quality oat grain for food production leads to the need for studying the resistance of this cereal crop to harmful diseases and for the development of new productive cultivars.

Materials and methods. A comparative characterization was performed among the breeding lines of naked oats from Nemchinovka Federal Research Center according to the parameters of microbiological purity of grain. The mycological method was applied for the analysis of infection in the oat grain, and fungal species composition was identified. The DNA amount of toxin-producing species from genus Fusarium Link in the grain was detected using the real-time PCR, and the amount of mycotoxins was measured by the enzyme immunoassay.

Results. The fungi of Alternaria Nees, Fusarium, Cladosporium Link, Cochliobolus Drechsler, Epicoccum Link were associated with oat grain. Uniquely high infection of the grain by F. langsethiae Torp & Nirenberg (14%) was found under the natural conditions of the Central Region of Russia. The differences revealed among the analyzed breeding lines and cultivars in the DNA amount of F. langsethiae and F. sporotrichioides Sherb. were from 1.3×10-4 to 7.2×10-3 pg/ng in the total DNA, and from 5 to 1230 μg/kg in the content of T-2/ HT-2 toxins.

Conclusion. All naked oat breeding lines were relatively resistant to Fusarium infection and proved the best as regards the mycotoxin contamination of the grain against the reference hulled cultivar ‘Yakov’. In the competitive variety trials, three lines – 66h2618, 54h2476 and 70h2613 – were characterized as relatively resistant to Fusarium disease, compared with the naked oat reference ‘Vyatsky golozerny’.
Changes in oat grain yield and quality with increased adaptability of cultivars
Authors: Nikolaev P. N. , Yusova O. A. , Safonova I. V. , Aniskov N. I.
Published: June 2020

Background. Among spring cereals, oat is one of the main grain crops in Siberia. The aim of this study was to determine how the parameters of adaptability in oat cultivars are correlated with yield and basic indicators of grain quality.

Material and methods. The studies were carried out from 2011 to 2019 in the southern forest steppe of Western Siberia. The content of protein, crude fat and starch in grain, and its hull content were measured according to B. V. Pleshkov and N. S. Berkutova. Mathematical processing was performed following the guidelines by B. A. Dospekhov, S. A. Eberhart and W. A. Russell.

Results. There was a significant variation in grain yield and grain quality (CV > 20%) in oat cultivars due to a high contribution from the conditions of the year (26.7...80.9%) as well as a strong direct (r = 0,607...0.825) or strong reverse (r = –0.660...–0.994) conjugation with climatic factors. As the protein content in grain increased, starch, oil (r = 0.960...0.962) and hull content (r = 0.442) increased as well. Naked oat cultivars manifested higher grain quality (4.6% protein, 17.6% starch, and 2.2% crude fat) and reduced yield (–1.45 t/ha) compared with hulled oat cultivars.

Conclusion. Increased plasticity (bi) and stability (σ2d) of oat cultivars contributed to higher yields (rbi = 0.943;rσ2d = 0.344) but reduced grain quality indicators (rbi = –0.697…–0.812;rσ2d = –0.270…–0.300). Hull content in plastic cultivars decreased (rbi = –0.201).
Evaluating the representativeness of the bentgrass (Agrostis L.) gene pool collected across the Russian Federation and neighboring countries in the VIR collection
Authors: Malyshev L. L.
Published: June 2020

Various species of bentgrass (Agrostis L.) are an important component of natural pastures. They are used to prepare forage grass mixtures or set up lawns; there are released cultivars. The collection of bentgrass held by VIR currently consists of 576 accessions. A. gigantea Roth is represented mainly by wild accessions; A. stolonifera L., A. canina L., and A. tenuis Sibth. by cultivars and breeding material of foreign origin. The representativeness of the gene pool and the distribution of germplasm collecting sites over the territory of the ex-USSR have been evaluated, and the species diversity has been analyzed within the collection. The regions have been identified that need to be addressed by collecting missions to fill ‘the gaps’ in the geographic, environmental and taxonomic range of bentgrass species. The passport database of VIR’s bentgrass collection and electronic maps of the ex-USSR administrative subdivisions served as the material for the research. A total of 176 administrative subdivisions were accepted as operational units and studied. For each of them, the total number of Agrostis spp. and the total number of accessions collected in its territory were taken into account. Among the eleven species collected, A. gigantea was analyzed in more detail. It appeared that the Northwest of the European part of Russia, Western Siberia, Sakhalin Province, and the Republic of Yakutia were most fully explored by collecting teams. However, the taxonomic and population diversity of bentgrass has not practically been mobilized so far in the southern parts of the Non-Black-Soil and Black-Soil zones, Middle and Lower Volga regions, North Caucasus, Eastern Siberia, and the Far East of Russia. Poorly represented in the collection is the taxonomic diversity of wild bentgrass accessions. The Russian Far East, mountainous areas of the Central Asian Republics, and the Northern and Central Urals are of the greatest interest for filling this gap.
How to select a true leader?
Authors: Trojak Nataša , Galić Zvonimir
Published: June 2020

Organizations mark the life of every individual, and the success and well-being of an individual largely depends on the success of organizations they belong to. The success of an organization is significantly influenced by those who are in charge of it, leaders or managers, so it is important for organizations to choose those who will do this job well. There is a large number of studies with the subject of successful leadership, and the dominant ones are those in which the traits of a successful leader are investigated. One of the traits identified as an important element of a leader’s success is the power motive. It consists of implicit and explicit dimensions, and the implicit dimension has been shown to be an important, and yet mostly overlooked, determinant of leadership performance. Measurement of the implicit dimension requires specially crafted instruments, including the “classic” Thematic Apperception Test, as well as recently introduced instruments such as the Implicit Association Test and the Conditional Reasoning Test for Power Motive. In this paper, we argue that introduction of the tests that assess implicit power motive to human resource management practice of business organizations might significantly improve selection procedures for leadership positions.
The effects of digital media buying on advertisers
Authors: Šehić Lejla , Peštek Almir
Published: June 2020

Although the Internet has become the essence of communication, from an advertiser’s perspective digital advertising remains underexplored. This paper examines the effects of digital media buying efforts on advertisers in Bosnia and Herzegovina, while looking into the methodology of digital media usage behind the actual effects. A combination of secondary research analysis and qualitative research techniques was used. The empirical part is based on in-depth interviews with advertisers and representatives from the digital advertising industry.Perceptions and knowledge of digital advertising are the key drivers for a successful implementation of digital media buying, and advertisers in Bosnia and Herzegovina are aware of its most distinctive qualities. The success of the media buying campaigns relies on brand objectives and choosing the means suited for fulfilling the given goals, which in turn leads to the findings that the focus of companies’ strategies is directed towards the cost-efficient medium usage, rather than solely performance-oriented ones. Measurement of the effects and return on the investment depends on the success of setting up a goal and isolating digital from other marketing efforts.
Determinants of household recycling
Authors: Pavlinović Mršić Slađana , Stojan Anita
Published: June 2020

A case of managing a public utility in post-transitional context is elaborated in this paper. The aim is to identify main determinants of household recycling, in order to make recommendations for design of appropriate recycling policy in Split (Croatia). Based on the overview of relevant literature, individual motivation towards waste selection is explored and preliminary survey results are presented. Implications for local policy-making and management of local public utilities are discussed.
Perceptions of administrative staff on career advancement realities at a South African university
Authors: Erasmus Barney
Published: June 2020

The necessary training and development to equip staff to fill critical positions accounts for a substantial percentage of the annual budget of universities. This article reports on perceptions on career advancement among administrative staff at a South African university. This study extends the existing body of knowledge concerning the barriers to career advancement at universities. Qualitative research approach was adopted, with the sample consisting of 14 middle-ranking members of the administrative staff, who had been identified for possible senior management posts. Empirical results identified barriers which limit career advancement, namely that there has been a shift from a collegial to a managerial governance model; and that a perceived silo mentality has led to increasing politicisation of the workplace. Furthermore, a lack of managerial skill means that training opportunities and departmental goals are not well communicated to staff members; and inadequate career guidance, retention strategies and opportunities for promotion are all responsible for reducing prospects of career advancement. However, the participants indicated that they had not lost hope and would continue to perform to the best of their ability and even go beyond what was expected of them. Managers should, however, not lose sight of the possibility that morale and productivity will suffer, if talented employees become dissatisfied, and that future leaders may resign, with a consequent failure to achieve departmental goals. The results of this study may serve as a wake-up call to university management: strategies aimed at the retention of administrative staff and at promotion policies need to be revised because the staff that make up this cohort perform essential university services.
Instilling The Conservation Character Through Reconstruction of Scientific Knowledge Based on Local Wisdom
Authors: Ismawati Riva , Juliyanto Eko , Prajoko Setiyo , Rahayuningsih Eva
Published: June 2020

The purpose of this study is to reconstruct scientific knowledge based on local wisdoms of the Ngargomulyo village people in preserving the environment as a means to instill and enhance the conservation caracter for prospective science teachers. The research is a qualitative study of ethnosains, which means the study of an organized system of knowledge from the culture and local wisdoms of a community. The research subjects are the residents of Ngargomulyo village. The focus of the research is the value of environmental preservation which is manifested in the behavior patterns of the people of Ngargomulyo village. The data collection is done through interviews and in-depth observation. The data obtained is then verified, reconstructed, formulated, and conceptualized into the scientific knowledge. The results of the study indicate that efforts made by the people to preserve the surrounding environment are manifested in farming, raising livestock, forest activities, and sand and stone mining activities. In addition, the activities to protect the environment for natural conservation are also evident from the efforts to maintain spring water sources. The environmental preservation messages are also found on some boards installed in certain places.

Keywords: conservation character, local wisdoms, Ngargomulyo village
Record on Macroscopic Fungi at IPB University Campus Forest : Description and Potential Utilization
Authors: Putra Ivan Permana
Published: June 2020

Fungi are ubiquitous and worldwide in distribution. It is estimated that tropical region such as Indonesia has high diversity of macro fungi. Studies on the diversity and potential utilization of macrofungi have gained significance during the recent years in Indonesia. However, information provide in the term of institutional area are still limited, and campus forest is no exception. The aim of this study was to collect information of mushroom diversity at IPB Unversity Campus Forest as inital step to maximize the potential utilization in the future. All mushrooms found were Basidiomycota which dominated by the order of Agaricales. A total of 11 mushroom were identified and described in this study,  namely : Crinipellis sp., Marasmius sp.1, Marasmius sp.2, Termitomyces sp., Cortinarius sp., Coprinellus sp., Pluteus sp., Gymnopus sp., Schizophyllum sp., Lentinus sp.1,and Lentinus sp.2. Some wild macroscopic fungi found to be potentially used as food source, secondary metabolites source, medicine, and also decomposer in sampling site.

Keywords: Macro Fungi, Diversity, Potency, IPB University.
OCORRÊNCIA E DIAGNÓSTICO DO CÂNCER DE COLO DO ÚTERO EM BARRA DO GARÇAS – MT
Authors: da Silva Priscilla Nicácio , Carvalho Andiara , De Souza Thayanne Gabrielly Ribeiro , Katagiri Satie
Published: June 2020

O câncer do colo do útero atualmente é considerado um importante problema de saúde pública, especialmente por se tratar do terceiro tipo de câncer mais prevalente em mulheres. Considerando a gravidade desta patologia, o objetivo do presente estudo foi investigar o perfil de atendimento no rastreamento do câncer do colo de útero, correlacionando o trabalho laboratorial com o relatório de coletas do SISCOLO. O estudo possui natureza retrospectiva, descritiva, exploratória e quantitativa, com dados coletados a partir dos relatórios internos de registros citopatológicos do laboratório e do relatório anual do SISCOLO no Município de Barra do Garças, Mato Grosso. Evidenciou-se que o município coletou e analisou cerca de 65% de material citopatológico da população total de mulheres. Não houve quantidade significativa de amostra insatisfatória (0,5%), sendo a maior parte das amostras satisfatórias para análise.  Persistiram no material analisado 0,8% de lesão intra-epitelial de baixo grau, 0,5% de lesão intra-epitelial de alto grau e 0,01% de adenocarcinoma in situ. Conclui-se que o Município não consegue cumprir a meta para rastreamento do câncer do colo de útero preconizado pelo Ministério da Saúde sendo evidenciado baixa taxa de coleta de material e baixa prevalência de lesões intra-epiteliais precursoras do câncer do colo do útero. Desta forma, ações mais efetivas e incisivas devem ser realizadas com vistas à divulgação da importância do exame preventivo bem como dos métodos de controle e profilaxia da doença entre mulheres.
Rare clinical case: Autoimmune hepatitis type 3
Authors: Zharova M. E. , Grigoreva Yu. V. , Nikonov E. L. , Ivanikov I. O. , Grebneva O. S.
Published: June 2020

Background. The fi rst clinical case of autoimmune hepatitis (AIH) was described in 1951, and in the 1970s, several randomized clinical trials proved the eff ectiveness of glucocorticosteroids in the treatment of AIH. Nonetheless, this disease remains a mystery to clinicians due to its rarity and heterogeneity. Aim. To describe the clinical case of the patient with AIH (SLA/LP antibodies) and discuss its management. Clinical case. A 22-year-old male with an acute manifestation of autoimmune hepatitis and a delayed, isolated increase of autoantibodies (SLA/LP). The initial diagnosis was made based on hypergammaglobulinemia and the eff ectiveness of glucocorticosteroids. Highly specifi c antibodies were detected only after 3.5 months, and the AIH was confi rmed histologically. Conclusion. This clinical case emphasizes the need to isolate type 3 AIH due to the more severe course and common relapse after the withdrawal of immunosuppressive therapy.
Barrett’s esophagus: genetic features
Authors: Belova G. V. , Rudenko O. S. , Karmakova T. A. , Yudakova M. E. , Sidorenko V. S.
Published: June 2020

The aimof the study was to evaluate the genetic characteristics of the pathological process in patients with biopsy-proven PB.Materials and methods:Dynamic observation and treatment of patients with morphologically confi rmed diagnosis of Barrett’s esophagus (PB) was performed at the Bank of Russia Multidisciplinary medical center in Moscow in the period from 2014 to 2019.the study included 52 patients. Among them, men — 33 (63.4%) and women –19 (36.5%) aged from 28 to 70 years, the peak incidence was mainly in the age range from 50–71 years. As a result, morphological types of PB epithelium were identifi ed at the time of the study: cardiac — 8(15.3%), small — bowel — 25 (48%), large-bowel without dysplasia-17 (32.6%) and large-bowel with mild dysplasia foci –2 (3.8%). The expression of the p53, P63, and Ki-67 genes responsible for cell proliferation and diff erentiation was studied using an immunohistochemical method.Results.As a result of the study, it was found that genetic changes in patients with morphologically confi rmed PB increase from the cardiac type of epithelium in the segment to the detection of dysplasia foci on the background of colonic metaplasia. An exception is tokokishechnaya metaplasia, which may be an indirect sign of the development of highly diff erentiated epithelium in response to gastroesophageal or duodenogastroesophageal refl uxSummary.1. Mutation of the p 53 genes responsible for regulating cell transcription and activating apoptosis and the P63 gene responsible for cell diff erentiation occurs in all morphological types of PB, with the number of mutations increasing as metastatic changes progress in accordance with the Correa cascade 2. The combination of p53 and P63 gene mutations in almost equal proportions indicates parallel processes of cell proliferation and diff erentiation disorders. 3. Ki-67 expression increases from the cardiac type of epithelium in the segment to the detection of dysplasia foci on the background of metaplastic epithelium. An exception is tokokishechnaya metaplasia, which may be an indirect sign of the development of highly diff erentiated epithelium in response to gastroesophageal or duodenogastroesophageal refl ux.Conclusion.Studies have shown that there are a number of genetic features of the pathological process in patients with morphologically confi rmed PB, the combination of which is more reliable and reliable assessment of the risk of neoplastic changes than individual indicators. To date, it remains relevant to develop a marker panel that is suitable for use in clinical practice, informative for both assessing individual risk and stratifying risk groups, and useful for monitoring the eff ectiveness of treatment.
Components of the diff use endocrine system of the gastrointestinal tract and nonalcoholic fatty liver disease: interconnections and mutual infl uences
Authors: Kozlova I. V. , Lapteva E. A. , Bykova A. P. , Pakhomova A. L.
Published: June 2020

Objective: To study the interconnections and mutual infl uences of the components of the diffuse endocrine system of the gastrointestinal tract and non-alcoholic fatty liver disease (NAFLD). Materials and methods: 138 patients with NAFLD and intestinal pathology, 36 patients without intestinal dysfunction were examined. The morphometric indicators of the expression of colonocytes immunopositive to the vascular endothelial growth factor, as well as to leptin, were compared with the clinical and endoscopic features of the colon and liver, and the functional and structural parameters of the liver were evaluated. Correlations of the studied indicators are revealed. A mathematical model is proposed that takes into account, along with the functional characteristics of the liver, structural, immunohistochemical, and morphometric parameters of the colon mucosa, which allow predicting the stage of liver fi brosis. Results: It was established that NAFLD is characterized by a dysregulation of diff use endocrine system parameters, which makes a certain contribution both to the formation of structural changes in the colon and to the progression of liver fi brosis.
Biological markers of Barrett’s esophagus progression to adenocarcinoma
Authors: Karmakova T. A. , Pirogov S. S. , Kaprin A. D.
Published: June 2020

Barrett’s esophagus (BE) is a condition in which a stratifi ed squamous epithelium of the distal esophagus is replaced with a metaplastic intestinal-type columnar epithelium. BE is a precancerous condition associated with an increased risk of esophageal adenocarcinoma (EA). Current clinical practice guidelines recommend endoscopic surveillance with histological examination of esophageal biopsies for early detection of the EA. Epithelial dysplasia is the only clinically meaningful indicator of the risk for development carcinoma in BE, which is now used in practice. The existing limitations of this approach require new tools for the detection of early neoplastic disorders in BE and additional criteria to assess a risk for their progression. Within the framework of this review, the most signifi cant genetic and molecular indicators that can claim the role of diagnostic or predictive biological markers in BE are considered.
Globalización, valoración cultural Y patrimonio gastronómico
Authors: Llano Fabián Andrés
Published: June 2020

En los actuales procesos de globalización cultural, económica y tecnológica, es común observar una fuerte tendencia de la industria turística a la mezcla con los avances científicos y tecnológicos. Esta previsión tecnológica que requiere el país para facilitar el acceso del turista a los diferentes productos turísticos mediante diversos sistemas de información, redefine la función de distribución y por supuesto el papel del turista como cliente. En un mundo en constante cambio, la tecnología puede garantizar la permanencia de agencias de viajes y proveedores de turismo, mediante el desarrollo e implementación de soluciones de este tipo que les permitan impulsar la distribución y comercialización de productos y servicios turísticos, a nivel nacional einternacional.
Covid-19 and the evolution of the virus, which we can say at the end of June 2020.
Authors: Banoun Helene
Published: June 2020

ABSTRACTHow can we explain the temporal evolution of the pandemic?The mutations in the viral RNA sequence observed in recent studies concern regions involvedin the interaction of the virus with cells of the host immune system. It therefore seems to be confirmed that the emerging virus has adapted to the host immune system by modifying its transmissibility and virulence. The virus adapts by natural selection to the immune system of its host (the human population); it is the sum of these individual adaptations that produces the overall evolution of the virus during the epidemic. This hypothesis is consistent with the Theory of Evolution, which often helps to solve puzzles in biology.
Understanding selenium and glutathione as antiviral factors in COVID-19: Does the viral Mpro protease target host selenoproteins and glutathione synthesis?
Authors: Taylor Ethan , Radding Wilson
Published: June 2020

Glutathione peroxidases (GPX), a family of antioxidant selenoenzymes, functionally link selenium and glutathione, which both show correlations with clinical outcomes in COVID-19. Thus, it is highly significant that cytosolic GPX1 has been shown to interact with an inactive C145A mutant of Mpro, the main cysteine protease of SARS-CoV-2, but not with catalytically active wild-type Mpro. This seemingly anomalous result is what might be expected if GPX1 is a substrate for the active protease, leading to its fragmentation. We show that the GPX1 active site sequence is substantially similar to a known Mpro cleavage site, and is identified as a potential cysteine protease site by the Procleave algorithm. Proteolytic knockdown of GPX1 is highly consistent with previously documented effects of recombinant SARS-CoV Mpro in transfected cells, including increased reactive oxygen species and NF-kappaB activation. Because NF-kappaB in turn activates many pro-inflammatory cytokines, this mechanism could contribute to increased inflammation and cytokine storms observed in COVID-19. Using web-based protease cleavage site prediction tools, we show that Mpro may be targeting not only GPX1, but several other selenoproteins including SELENOF and thioredoxin reductase 1, as well as glutamate-cysteine ligase, the rate-limiting enzyme for glutathione synthesis. This hypothesized proteolytic knockdown of components of both the thioredoxin and glutaredoxin systems is consistent with a viral strategy to inhibit DNA synthesis, to increase the pool of ribonucleotides for RNA synthesis, thereby enhancing virion production. The resulting “collateral damage” of increased oxidative stress and inflammation would be exacerbated by dietary deficiencies of selenium, glutathione and glutathione precursors.
Physical activity and sedentary behaviour during the COVID-19 pandemic: An Australian population study
Authors: Kunstler Breanne , Slattery Peter , Grundy Emily , Goodwin Denise , Saeri Alexander K
Published: June 2020

BACKGROUND:Participating in physical activity (PA) and minimising time spent sedentary is important to achieve and maintain good health. Time spent being physically active and sedentary could be negatively influenced by the 2019 global pandemic where home confinement restrictions are commonplace internationally. The aim of this study was to identify the percentage of Australian adults meeting the PA and sedentary behaviour guidelines during the COVID-19 pandemic.METHODS:Australian adults participated in a cross-sectional online survey examining PA and sedentary behaviours during April, 2020. Descriptive statistics were produced for demographic, PA and sedentary behaviour variables.RESULTS:1,084 Australian adults responded to the survey. The majority of respondents did not meet the aerobic (n=756,70%) or strength (n=649,60%) components of the guidelines. The majority of respondents (n=609,58%) participated in low sedentary time (<9hr/day). CONCLUSION:Compared to previous studies and national data, the percentage of Australian adults meeting the strength component of the guidelines increased while the percentage meeting the aerobic and sedentary time components decreased. The reduction in activity and increase in sedentary time could be due to the enforcement of home confinement restrictions. It is important to provide opportunities for people to maintain activity during pandemics to avoid poor health outcomes.
Morfologi Bahasa Indonesia
Authors: HARZIKO
Published: June 2020

Morphology, the form of word science, or sometimes called neuroscience is a branch of linguisticsthat identifies the basic units of language as grammatical units. Morphology studies the ins andouts of word forms and the effect of word shape changes on word groups and meanings. Thisresearch describes the process of Indonesian language morphology. data and data sourcesnamely literature namely treori comparisons between Indonesian language that are good andright among students. The data and sources of this research are the utterances spoken bystudents. The results show that words are categorized as verbs if in the phrase can beaccompanied by particles not in construction and cannot be accompanied by particles in, to, from,or with particles such as very, more, or somewhat subcategorized verbs, interactions betweentheir companion nouns, Telis and verbs and Atelis Verb.Keyword. Morpholog, Verb, Indonesian
Children Coping, Contextual Risk and their Interplay during the COVID-19 Pandemic: a Spanish Case
Authors: Domínguez-Álvarez Beatriz , López-Romero Laura , Isdahl-Troye Aimé , Gómez-Fraguela José Antonio , Romero Estrella
Published: June 2020

The COVID-19 pandemic has changed the lives of millions of people around the globe and some of the unprecedent emerged disruptions, are likely to have been particularly challenging for young children (e.g., school closures, social distancing measures, movement restrictions). Studying the impact of such extraordinary circumstances on their well-being is crucial to identify processes leading to risk and resilience. To better understand how Spanish children have adapted (or fail to) to the stressful disruptions resulting from the pandemic outbreak, we examined the effects of child coping and its interactions with contextual stressors (pandemic and family-related) on child adjustment, incorporating in our analysis a developmental perspective. Data was collected in April 2020, through parent-reports, during the acute phase of the pandemic and, temporarily coinciding with the mandatory national quarantine period imposed by the Spanish Government. A sample of 1,123 Spanish children (50% girls) aged three to 12 (Mage = 7.26; SD = 2.39) participated in the study. Results showed differences in the use of specific strategies by children in different age groups (i.e., 3-6, 7-9 and 10-12-year-olds). Despite the uncontrollable nature of the pandemic-related stressors, child disengagement coping was distinctively associated to negative outcomes (i.e., higher levels of behavioral and emotional difficulties), whereas engagement coping predicted psychosocial adjustment across all age groups. Moreover, interactively with child coping, parent fear of the future and parent dispositional resilience appear as relevant contextual factors to predict both negative and positive outcomes, but their effects seem to be age dependent, suggesting a higher contextual vulnerability for younger children. These findings might have implications for identifying individual and contextual risk and informing potential preventive interventions aimed to reduce the impact of future pandemic outbreaks on children of different ages.