bluuebunny/crossref_metadata_2025 huggingface dataset:
The Dynamics and Frontiers of Video Game Social Research in Communication Studies-A Scientometrics Analysis Based on CiteSpace and VOSviewer
Authors: Zhao Fan , Alsagoff Syed Agil , Abdullah Karmilah , Wu Xuanyi
Published: October 2023

In this media-rich era, digital entertainment in the form of video games has a major impact on our social interaction and productivity in a borderless social mode. As a result, in order to comprehend the research progress of video game, CiteSpace and VOSviewer were used for scientometrics and knowledge mapping in this study. It displays the state of development, fundamental structure, and frontier areas of video game social communication. The mapping is based on 448 publications collected through Web of Science core database searches. The findings indicate that (1) video game social research has gained increasing attention over the last 23 years, with a curvilinear growth in annual publications, but a core authorship group has yet to materialize, and the United States institutions dominate the number of publications on this topic. (2) Gaming behaviors, gender studies, media effects, and gaming experiences have emerged as the four main hotspots of research in this field under the keyword co-occurrence and clustering analyses. (3) Research in this area has traditionally concentrated on violent, addictive, and other problematic gaming behaviors. The findings of this study forecast future trends in the study of video game social communication and provide the groundwork for more in-depth research.
Digital Media Reshaping Art Education: A Literature Review in the Age of COVID-19
Authors: Smanov Ilishan , Stycheva Olga , Smanova Gaziza , Zholdasbekova Bibigul , Isatayeva Gulzhan
Published: October 2023

This study aims to conduct a bibliometric analysis in the field of digital media in arts education. The study's primary objectives were identifying the main topics, authors, sources, and most cited articles. In addition, the study aims to develop a knowledge base on the use of digital media in arts education. We analyzed articles indexed in major scientific databases such as Web of Science and Scopus to achieve these goals. The study results include quantitative analysis supported by tables, graphs, and maps, focusing on digital media in the arts and key performance indicators of scientific production and citations. The total number of articles reviewed was 239, of which 149 were analyzed in detail. The study was an inductive analysis resulting in significant categories of papers cited. These categories include art learning and the use of digital media in art education, the use of digital media in various areas of art education, learning processes using digital media, and current topics related to the COVID-19 pandemic. The study makes an important contribution to understanding the dynamics of the digital media field in education, particularly in the arts context. It can be a starting point for future research and development.
Classification of regular subalgebras of injective type III factors
Authors: Chakraborty Soham
Published: October 2023

We provide a complete classification for regular subalgebras [Formula: see text] of injective factors satisfying a natural relative commutant condition. We show that such subalgebras are classified by their associated amenable discrete measured groupoid [Formula: see text] and the action modnew([Formula: see text]) of [Formula: see text] on the flow of weights induced by the cocycle action [Formula: see text] of [Formula: see text] on [Formula: see text]. We obtain a similar result for triple inclusions [Formula: see text], where [Formula: see text] is an injective factor, [Formula: see text] is a Cartan subalgebra of [Formula: see text] and [Formula: see text] is regular, showing that such inclusions are also classified by their associated groupoid [Formula: see text] and the induced action on the flow of weights. Given such a discrete measured amenable groupoid [Formula: see text], we also construct a model action of [Formula: see text] on a field of Cartan inclusions with prescribed action on the associated field of flows.
Geometry of Hermitian symmetric spaces under the action of a maximal unipotent group
Authors: Geatti Laura , Iannuzzi Andrea
Published: October 2023

Let [Formula: see text] be a non-compact irreducible Hermitian symmetric space of rank [Formula: see text] and let [Formula: see text] be an Iwasawa decomposition of [Formula: see text]. The group [Formula: see text] acts on [Formula: see text] by biholomorphisms and the real [Formula: see text]-dimensional submanifold [Formula: see text] intersects every [Formula: see text]-orbit transversally in a single point. Moreover [Formula: see text] is contained in a complex [Formula: see text]-dimensional submanifold of [Formula: see text] biholomorphic to [Formula: see text], the product of [Formula: see text] copies of the upper half-plane in [Formula: see text]. This fact leads to a one-to-one correspondence between [Formula: see text]-invariant domains in [Formula: see text] and tube domains in [Formula: see text]. In this setting we prove an analogue of Bochner’s tube theorem. Namely, an [Formula: see text]-invariant domain [Formula: see text] in [Formula: see text] is Stein if and only if the base [Formula: see text] of the associated tube domain is convex and “cone invariant”.

We also prove the univalence of [Formula: see text]-invariant holomorphically separable Riemann domains over [Formula: see text]. This yields a precise description of the envelope of holomorphy of an arbitrary [Formula: see text]-invariant domain in [Formula: see text]. Finally, we obtain a characterization of several classes of [Formula: see text]-invariant plurisubharmonic functions on [Formula: see text] in terms of the corresponding classes of convex functions on [Formula: see text]. As an application we present an explicit Lie group theoretical description of all [Formula: see text]-invariant potentials of the Killing metric on [Formula: see text] and of the associated moment maps.
Two spectral Gegenbauer methods for solving linear and nonlinear time fractional Cable problems
Authors: Atta A. G.
Published: October 2023

This research aims to analyze and implement two numerical spectral schemes for solving linear and nonlinear time fractional Cable equations (TFCEs). Two modified sets of shifted Gegenbauer polynomials (SGPs) are used as basis functions. The approximation of the solution is written as a product of the two chosen basis function sets. For these methods, the principle idea is to convert the problem governed by the underlying conditions into a set of linear and nonlinear algebraic equations that can be solved using appropriate numerical techniques. The upper estimate of the truncation error for the proposed expansion is investigated. In the end, four examples are presented to illustrate the accuracy of the suggested schemes.
SPIRITUALITY, RELIGIOSITY AND HAPPINESS: IDENTIFYING THE NEXUS
Authors: HO LOK SANG
Published: October 2023

Using data from 52 countries in Wave 5 of the World Value Survey conducted during 2004 and 2008, we test two alternative approaches in spirituality measures. The first is based on the more traditional understanding that spirituality is associated with meanings, God, prayers/meditation and formal religions. The second is based on the common spiritual teachings of all the major religions that are summarized by the LIFE (Love, Insight or Wisdom, Fortitude and Engagement) framework proposed by Ho, LS (2014). Psychology and Economics of Happiness: Love, Life and Positive Living. Oxford: Routledge. It was found that this alternative approach, which focuses on the spiritual teachings rather than theology, offers better explanatory power for Total Life Satisfaction (TLS). An interesting finding is that under this specification the coefficient on meaning turned negative, suggesting that those whose lives are weak in Love, Insight, Fortitude and Engagement have yet to find meaning and are less happy. Through a series of stepwise regressions, we conclude that more spiritual people are indeed happier (H1); that religious people indeed tend to be happier mainly because religious people tend to be more spiritual (H2); that the essence of spirituality and meaning lies in Love, Insight, Fortitude and Engagement (H3). These virtues are all grounded on transcending the narrow self and on a “reverence for Life” as propounded by Schweitzer. Finally, religious attendance does promote happiness. The effect is small but stable and statistically significant. It may have to do with the social network this offers (H4).
STMultiple: Sparse Transformer Based on RFID for Multi-Object Activity Recognition
Authors: Shen Shunwen , Yang Mulan , Hou Xuehan , Yang Lvqing , Chen Sien , Dong Wensheng , Yu Bo , Wang Qingkai
Published: October 2023

Wireless sensing techniques for Human Activity Recognition (HAR) have been widely studied in recent years. At present, research on HAR based on Radio Frequency Identification (RFID) is changing from the tag attachment method to the tag non-attachment method. Affected by multipath, the current solutions in tag non-attachment scenarios mainly focus on single-object activity recognition, which is not suitable for multi-object scenarios. To address these issues, we propose STMultiple, a novel tag non-attachment activity recognition model for multi-object. The model first preprocesses the raw signal with filter and phase calibration, then it applies dilated convolution in the frequency domain to extract multi-object activity features, finally the feature pyramid structure and ProbSparse are used to optimize the vanilla Transformer-Encoder to enhance the activity recognition ability. Extensive experiments show that STMultiple can achieve recognition accuracy of up to 97.93% and down to about 90% in challenging environments ranging from two to five users, which has excellent performance compared to several state-of-the-art methods.
Agile Effort Estimation: Comparing the Accuracy and Efficiency of Planning Poker, Bucket System, and Affinity Estimation Methods
Authors: Poženel Marko , Fürst Luka , Vavpotič Damjan , Hovelja Tomaž
Published: October 2023

Published studies on agile effort estimation predominantly focus on comparisons of the accuracy of different estimation methods, while efficiency comparisons, i.e. how much time the estimation methods consume was not in the forefront. However, for practical use in software development, the time required can be a very important cost factor for enterprises, especially when the accuracy of different agile effort estimations is similar. In this study, we thus try to advance the current standard accuracy comparison between methods by introducing efficiency, i.e. time it takes to use a method as an additional dimension of comparison. We conduct this comparison between three agile effort estimation methods that were not yet compared in the literature, namely, Planning Poker, Bucket System and Affinity Estimation. For the comparison, we used eight student teams with 29 students who had to use all the effort estimation methods during the course where they had to finish a programming project in 3 weeks. The results indicate that after the students get used to using the different methods the accuracy between them is not statistically significantly different, however, the efficiency is. On average, Bucket System and Affinity Estimation methods take half as much time as Planning Poker.
Smart Quality Decision-Making Model for Mobile Assistive Devices
Authors: Chen Kuen-Suan , Yu Chun-Min , Chen Chi-Han
Published: October 2023

With the gradual maturity of the Internet of Things environment, the collection and analysis technology of production data is continuously improved, and the improvement of product process quality and safety performance can not only increase product value but also prolong product life, in order to achieve the goal of energy-saving and waste-reducing green production. Therefore, this study used process capability indicators of important quality characteristics as evaluation tools for the manual wheelchair products and proposed a smart quality decision-making model for production data. First, we constructed an evaluation index for the important quality characteristics of the carbon fiber wheel rims to verify that each important quality characteristic can meet the required quality level. Next, based on the upper confidence limit of the evaluation index, the fuzzy decision index and fuzzy testing rules were established. In addition, the decision-making index was converted into the index observation value, and an intuitive fuzzy evaluation rule more convenient for practical application was established. Finally, we employed an easy-to-use radar evaluation chart to assess whether the index fell into the improvement range and decide whether to improve. In conclusion, this study considers the need of businesses for quick their responses to decision-making. The fuzzy testing design built on upper confidence limits can incorporate past data experience. It can still maintain the testing accuracy for small-sized samples. At the same time, it can also help enterprises pursue smart manufacturing and management and realize the business philosophy of sustainable development.
Graphical Deep Learning Prediction Model for Stock Risk Management
Authors: Byeon Haewon , Chitta Shyamsunder , Shavkatovich Shavkatov Navruzbek , Ansari Ghulam Jillani , Alhaisoni Majed , Zhang Yu-Dong
Published: October 2023

Forecasting the future movements of stock market indexes by utilizing historical transaction data is a prominent concern within the realm of finance. The application of graph convolutional networks to incorporate the interrelationships among various indices’ patterns is a highly advanced subject within this field. Addressing the inconsistency between historical and future dynamic graphs in current graph convolution-based index prediction, we propose a method called G-Conv that constructs a graph structure based on constituent stocks of the indices for index trend prediction. This approach extracts traditional quantitative features along with deep features from one-dimensional convolutional networks as characteristics of prediction samples. The method produces index trend predictions by constructing a graph structure using constituent stock data of indices and applying graph convolution to different index sample features. The proposed methodology’s efficacy is verified by utilizing 42 widely employed indicators in the A-share market. The experimental findings demonstrate that when utilizing mean absolute error (MAE) and mean squared error (MSE) as the loss functions for model training, G-Conv outperforms classic methods such as GC-CNN and ADGAT. Specifically, G-Conv reduces the average prediction errors by 5.10% and 4.20% respectively, as evaluated by the two error criteria. Additionally, G-Conv exhibits favorable generalization performance.
Dynamical Behavior of Two Coupled Two-Stroke Relaxation Oscillators
Authors: Ducci Daniele , Meucci Riccardo , Euzzor Stefano , Ginoux Jean-Marc , Di Garbo Angelo
Published: October 2023

Starting from [J.-M. Ginoux et al., Torus breakdown in a uni junction memristor, Int. J. Bifurcation Chaos 28(10) (2018) 1850128; J.-M. Ginoux et al., Torus breakdown in a two-stroke relaxation memristor, Chaos Solitons Fractals 153 (2021) 111594], we define a model which describes the dynamical behavior of a class of two-stroke oscillators (i.e., nonlinear oscillators with two distinct phases per cycle). We highlight some properties of the model still not taken into account, like presence of a global bifurcation and bistability for some regions of the parameters space. We then extend the model to study two coupled two-stroke oscillators, where synchrony and anti-synchrony regimes appear as well as transient chaos and intermittency phenomena. We finally compare the theoretical results on synchrony regimes with the corresponding experimental data obtained from a circuit where two relaxation oscillators, based on the Unijunction Transistor (UJT) electronic component, are coupled together. The comparison shows a good qualitative agreement between the experiments and the theoretical results.
Abundance and magnifying elements in transformation semigroups that preserve order and equivalence
Authors: Sun Lei
Published: October 2023

Let [Formula: see text] be a nontrivial equivalence relation on a totally ordered set [Formula: see text] and [Formula: see text] be the semigroup of all transformations of [Formula: see text] that preserve [Formula: see text]. In this paper, we consider a subsemigroup of [Formula: see text] defined by [Formula: see text] and present a necessary and sufficient condition under which the semigroup [Formula: see text] is abundant. Also, we describe all the left and right magnifying elements in [Formula: see text].
On the non existence of sympathetic Lie algebras with dimension less than 25
Authors: García-Pulido A. L. , Salgado G.
Published: October 2023

In this paper, we investigate the question of the lowest possible dimension that a sympathetic Lie algebra [Formula: see text] can attain, when its Levi subalgebra [Formula: see text] is simple. We establish the structure of the nilradical of a perfect Lie algebra [Formula: see text], as a [Formula: see text]-module, and determine the possible Lie algebra structures that one such [Formula: see text] admits. We prove that, as a [Formula: see text]-module, the nilradical must decompose into at least four simple modules. We explicitly calculate the semisimple derivations of a perfect Lie algebra [Formula: see text] with Levi subalgebra [Formula: see text] and give necessary conditions for [Formula: see text] to be a sympathetic Lie algebra in terms of these semisimple derivations. We show that there is no sympathetic Lie algebra of dimension lower than [Formula: see text], independently of the nilradical’s decomposition. If the nilradical has four simple modules, we show that a sympathetic Lie algebra has dimension greater or equal than [Formula: see text].
Robust portfolio selection for sparse index tracking under no short-selling and full investment constraints
Authors: Li Ning , Zhu Guanghui
Published: October 2023

For financial index tracking, it is desirable to build a sparse portfolio of a small number of assets to save transaction costs. For all we know, a majority of the pertinent literatures on sparse index tracking are mainly concentrated on the penalized least squares estimation under the cardinality and no short-selling constraints. Nevertheless, the return series of financial index often exhibit outliers, and thus the above literatures may fail to produce a robust solution for index tracking. In this paper, we indeed to provide a general procedure to build robust portfolio that can undertake stock selection and capital allocation for financial index tracking. To be more realistic, we further take the full investment constraint (or budget constraint) into consideration. Numerical simulations indicate that the proposed method has good resistance to heavy-tailed error and outlier contamination. Finally, the out-of-sample performance of the new portfolios is compared empirically by tracking the SSE 50 index and FTSE China A50 index.
Will the Innovation Drivers be Shaped by the Metaverses? A Theoretical Essay Based on a Systematic Mapping Study
Authors: Câmara Samuel , Allex Araújo Allysson , Buarque Brenno , Soares Pamella , Queiroz Letícia , Souza Jerffeson
Published: October 2023

The combination of metaverses and other recent technologies has sparked innovations in different industries. Driven by this motivation, our work aimed to articulate a theoretical essay covering the potential for innovation in the metaverses and its impacts on sociotechnical relations. Initially, a systematic mapping study was carried out, which allowed us to provide an analytical view of how the metaverse has been discussed in the light of innovation research. Then, we designed a framework (called MetaInnovation) grounded on the innovation drivers as elements of these sets of physical (domain) and metaverse (image) realities that are linked by the technologies that mediate these two worlds (realities). To the best of our knowledge, this is the first work which (i) conducts a systematic mapping study about the intersection between innovation and metaverse and (ii) offers an approach to address these specific sociotechnical constructs regarding metaverse innovation.
Critical Success Factors for Implementing Cloud ERP in SMEs: A Systematic Review
Authors: Barbieri Leonardo Moro , Sott Michele Kremer , Monticelli Jefferson Marlon
Published: October 2023

Digital transformation has transformed the business processes and operations of firms worldwide. Companies need to adopt new technologies capable of automating and boosting the business to maintain competitiveness in a global market. This study aims to identify the critical success factors (CSFs) that impact Cloud ERP implementation in small and medium enterprises (SMEs). A systematic literature review was conducted with the support of the PRISMA-P. The identified factors were classified following the technology–organization–environment (TOE) framework. The CSFs that stood out most were system compatibility with the organization’s needs, data security, and senior management commitment support. This study contributes to the literature by identifying and grouping the CSFs that most impact the implementation of Cloud enterprise resource planning (ERP) in SMEs and to the practice by serving as a guide for managers and decision-makers of SMEs.
ERP Systems in Humanitarian and Private Sectors’ Supply Chains: Challenges and Success Factors
Authors: Lukyanova Iryna , Haddud Abubaker , Khare Anshuman
Published: October 2023

Purpose: This paper investigates and compares challenges and success factors within different supply chain ERPs used globally across humanitarian and private organizations in Africa, Asia, Canada, Australia, Europe, and the Americas. Eighteen challenges and 27 success factors were selected from literature published between 2015 and 2020 to determine whether they are equally relevant globally in the private and humanitarian sectors.

Design/methodology/approach: The research utilized an anonymous online questionnaire advertised on different social media websites and completed by 50 humanitarian supply chain professionals and 53 private sector professionals worldwide. The collected data was analyzed using a descriptive statistic–crosstabulation analysis to show the differences or similarities in supply chain professionals’ opinions from humanitarian and private organizations. Additionally, the hypotheses were tested by using the Mann–Whitney Test.

Findings: Findings revealed that all the examined success factors were supported except one, which was similar in both sectors. However, the challenges during the implementation of ERPs differ in these two sectors — with four success factors not supported in the humanitarian sector and nine not supported challenges in the private sector.

Originality: This study’s significance is that, as per the researchers’ knowledge, such a comparative study was never done before, and it will allow both sectors’ professionals to understand all the elements mentioned above better and integrate them while implementing supply chain ERPs.
Viscous exotic fluid interacting with dark matter and future infinite singularities
Authors: Boko R. D. , Hova H. , Pomalegni Gisele F.E. , Gbetoho L. D. , Salako Ines G. , Houndjo M. J. S.
Published: October 2023

By making use of two viable Lagrangian [Formula: see text] models, we investigate the behavior of the state parameter of the interacting viscous dark energy. We, from constant deceleration parameter, explore the cosmological implications of the viscosity and interaction between the dark energy and dark matter in terms of redshift. We then construct the viscosity and the interaction parameters that are respectively parameterized by [Formula: see text] and [Formula: see text] and obtain interesting results. Later, we investigate the behavior of some bulk viscosity models describing little rip and pseudo rip future singularities within [Formula: see text] modified gravity. We obtain interesting gravitational equations of motion for viscous dark energy coupled with dark matter. The solution of these equations gives us an analytic expression for characteristic properties of these cosmological models.
Impacts of nonlocal fear effect and delay on a reaction–diffusion predator–prey model
Authors: Zhang Xuebing , Liu Jia , Wang Guanglan
Published: October 2023

In this research, we examine a predator–prey model in which nonlocal fear plays a role alongside delay in a reaction–diffusion framework. We integrate two delays into the model to account for the lag between when fear starts affecting the growth rate of prey and when it starts affecting the growth rate of the predator through feedback. The first step is to investigate local and global stability and bifurcations in the equilibrium states of the nondelayed model. We explore the Hopf bifurcation in the delayed model using the delay as the bifurcation parameter. Our theoretical findings are then backed up by certain simulations. It reveals how the system, depending on its level of anxiety and the time delays involved, displays a wide range of spatiotemporal patterns.
An SVIQR model with vaccination-age, general nonlinear incidence rate and relapse: Dynamics and simulations
Authors: Ouakka Abdellah , Elazzouzi Abdelhai , Hammouch Zakia
Published: October 2023

This work is concerned with the global dynamics of a Susceptible–Vaccinated–Infected–Isolated–Recovered model, denoted by SVIQR, with vaccination-age. Moreover, the considered model contains a relapse term and a general form of the incidence function. This model is formulated to show the effect of sanitary isolation and vaccination on the disease prevalence when the relapse phenomena occurs. First, we show that the model is mathematically well posed by using the integrated semigroup theory. Second, we prove the existence of equilibrium points based on the basic reproduction number [Formula: see text]. Moreover, by developing appropriate Lyapunov functionals and applying the LaSalles invariance principle, we established the global dynamics of the model, especially, we show that if [Formula: see text] the the disease-free equilibrium is globally asymptotically stable and, if [Formula: see text] the endemic equilibrium is globally asymptotically stable. Finally, using the finite difference method, numerical simulations are made to reinforce the theoretical findings and to prove the contribution of the vaccination and the isolation on the disease disappearing.
On weak-like comultiplication modules
Authors: Rashedi Fatemeh
Published: October 2023

Let [Formula: see text] be a commutative ring and [Formula: see text] be an [Formula: see text]-module. In this paper, we introduce and obtain some results concerning weak-like comultiplication [Formula: see text]-modules, which is a dual notion of weak multiplication [Formula: see text]-modules.
Product of generalized derivations with Engel condition on Lie ideals in prime rings
Authors: Dhara Basudeb , Kar Sukhendu , Singh Kalyan
Published: October 2023

This paper represents the structures of generalized derivations satisfying an identity with [Formula: see text]-Engel condition. To prove our result, we take [Formula: see text] as a prime ring with [Formula: see text], and [Formula: see text] as Utumi quotient ring of [Formula: see text]. The center of [Formula: see text] is [Formula: see text] which is called extended centroid of [Formula: see text]. Let [Formula: see text] be a non-central Lie ideal of [Formula: see text]. Suppose that [Formula: see text] and [Formula: see text] are two nonzero generalized derivations of [Formula: see text] and [Formula: see text], any fixed integer. If [Formula: see text] for all [Formula: see text], then one of the below-mentioned conclusions holds:

(1) [Formula: see text] and [Formula: see text] for all [Formula: see text] and for some [Formula: see text] with [Formula: see text]; (2) [Formula: see text] satisfies [Formula: see text].
Theoretical investigation of optoelectronic properties of Al-doped BAs using TB-mBJ approach
Authors: Badaoui Abdelhamid
Published: October 2023

For quite a long time, the scientific community has been searching for a material that surpasses the existing material systems in terms of energy conversion efficiency for photovoltaic applications. In this study, the optoelectronic properties of pure and Al-doped boron arsenide B[Formula: see text]Al[Formula: see text]As [Formula: see text] in the zinc blende (ZB) structure were systematically examined using the density functional theory (DFT) and the Modified Becke–Johnson (TB-mBJ) exchange correlation (XC) potential. The Perdew–Burke–Ernzerhof generalized gradient approximation (PBE) functional was used for structural optimization. After considering the ground state lattice constant of 4.82[Formula: see text]Å then calculating the bandgap energy of pure BAs, which are consistent with experimental and theoretical findings, we estimated the basic electronic and optical characteristics of Al-doped boron arsenide, including band structures, electronic density of state, dielectric function, refractive index, extinction coefficient, absorption and optical conductivity. The unusual and interesting optoelectronic features of the investigated compounds revealed in this work offer substantial promise for improving the energy conversion efficiency of solar cells.
Computational Screening of Potential Fatty Acid Synthase Inhibitors as Broad-Spectrum Antiviral Agents
Authors: Xu Shaohua , Yuan Huicheng , Li Ling , Yang Kai , Zhao Liangcun
Published: October 2023

Infectious diseases caused by viruses are one of the major diseases that seriously endanger global health. The development of broad-spectrum antiviral drugs for effective control of emerging and recurrent viral infectious diseases is urgently needed. Fatty acid synthase (FAS) has been reported as a valuable target for developing broad-spectrum antiviral drugs. In this study, we aimed to screen potent FAS inhibitors as broad-spectrum antiviral agents through computational approach. A pharmacophore model was generated with crystal structure of FAS in complex with Orlistat using Pharmit server, and 2,215 compounds were screened from ZINC15 database against the pharmacophore model. Next, 12 compounds exhibited more affinity to FAS than the control compound (Orlistat) were screened using molecular docking. The top three compounds (ZINC6146291, ZINC8925941 and ZINC3257427), which showed docking affinity to FAS with −8.19 kcal/mol, −8.14 kcal/mol and −8.07 kcal/mol, respectively, were subjected to 200 ns molecular dynamics simulation to evaluate the stability of docked complexes and their interaction mechanisms. The simulation trajectory analysis showed the stable conformation observed in FAS bound of the compounds and the screened compounds were firmly bound of the active sites of FAS throughout molecular dynamics simulation. The screened FAS candidate inhibitors can be used as broad-spectrum antiviral agents for in vitro-in vivo evaluations.
Development of a Novel CYP3A4 Classifier Model via Site of Metabolism (SOM)-based Molecular Docking, Multivariate Analysis and Molecular Dynamics of Known Substrates and Inhibitors
Authors: Mohamad Ridhwan Mohamad Jemain , Hashim Nurul Azmir Amir , Kasim Noraini , Abdullah Nor Nadirah , Inayatsyah Nurul Alam , Abid Obaidurahman , Ismail Nor Hadiani , Imran Syahrul
Published: October 2023

CYP3A4 is a major hepatic enzyme essential for metabolizing diverse chemical entities. The development of CYP3A4 substrate and inhibitor classifier models is a valuable research strategy to prevent toxicokinetics. Currently, no molecular docking model is available to classify the substrates and inhibitors for a wide range of chemical entities. This study generated a CYP3A4 substrate-inhibitor classifier model using multivariate analysis of selected variables from site of metabolism (SOM)-based docking results and molecular descriptors. CYP3A4 SOM-based molecular docking experiment was performed on the substrates and inhibitors from the DrugBank database. The relevant descriptors were selected using the area under the receiving operating curve (AUROC) and boxplot analysis. The selected variables were used to generate a CYP3A4 substrate-inhibitor classifier model using multivariate analysis. Two complexes were selected for molecular dynamic simulations. A total of 326 substrates and 154 inhibitors were successfully docked. The SOM-based docking model predicted 78.5% SOM correctly of the substrates. The CDOCKER energy, improper dihedral energy, potential energy, initial RMS (root mean square) gradient, and RMS gradient demonstrated acceptable AUROC, sensitivity, specificity, and Youden’s index results. The selected variables were subjected to multivariate analysis, and the PLS-DA analysis classification model showed promising performance in predicting chemical entities’ behavior as substrates or inhibitors. This model classified the external samples correctly with over 70.0% prediction accuracy. Molecular dynamic simulations showed that the selected complexes obtained from the docking model produced stable complexes. The classifier model is applicable as a research tool for the early stages of drug discovery.
Novel Specific SARS-CoV-2 miRNAs Targeting Human Genes Involved in COVID-19 Infection and Their Regulation by Bemcentinib and Zavegepant: A Promising Evidence for RNA-Based Repurposing Therapeutic Strategy
Authors: Singh Jitender , Avti Pramod K. , Khanduja Krishan L. , Dhawan Radhika , Sangwan Namrata , Chauhan Arushi
Published: October 2023

The 2019 coronavirus pandemic prompted extensive research into the molecular composition of the virus. The SARS-CoV-2 virus contains small noncoding RNAs (sNCR, miRNAs) targeting crucial host genes. This study identified 24 potential precursor and mature Viral-miRNAs (V-miRNAs) in the SARS-CoV-2 genome with favorable thermodynamic energies associated with 1883 human genes, 334 of which are involved in the COVID-19 infection. Out of 24, 14 predicted mature SARS-CoV-2 V-miRNAs target 28 host genes of the 334 genes involved in COVID-19 based on their robust molecular hybridization (thermodynamic stability, canonical base pairing, minimal noncanonical base pairs, loops, and bulges). Eight of the 14 mature V-miRNAs showed sequence conservancy with other organisms based on predicted 3D structures. Gene ontology enrichment analysis revealed these 28 host genes are involved in 42 biological processes, 4 cellular components, and 10 molecular processes. Further, the 14 predicted mature V-miRNAs were screened against FDA-approved (COVID-19 drug dataset) to identify the top best-hit compounds, which include Bemcentinib and Zavegepant. These two drugs show strong binding affinities ([Formula: see text]9.2 to −12.4 kcal/mol) with 13 and 12 predicted mature V-miRNAs, respectively. Furthermore, molecular docking of V-miRs-host AGO protein interactions suggested strong binding affinities and extensive hydrogen bonding interactions between V-miRNAs and the host AGO protein (involved in miRNA biogenesis and mRNA regulation). These findings suggest a potential regulatory role of Bemcentinib and Zavegepant through strong binding interaction with various V-miRNAs and in modulating host gene expression through their interactions with the AGO protein.
Exploring the Therapeutic Potential of Traditional Antimalarial and Antidengue Plants: A Mechanistic Perspective
Authors: Kamaraj Chinnaperumal , Ragavendran Chinnasamy , Prem Pradisha , Naveen Kumar Selvam , Ali Amir , Kazmi Abeer , Ullah Abd , Chandra Satish Kumar Rajappan , Khan Safir Ullah , Luna-Arias Juan Pedro , Mashwani Zia-Ur-Rehman , Balasubramani Govindhasamy , Rehman Saif Ur
Published: October 2023

Malaria, a highly perilous infectious disease, impacted approximately 230 million individuals globally in 2019. Mosquitoes, vectors of over 10% of worldwide diseases, pose a significant public health menace. The pressing need for novel antimalarial drugs arises due to the imminent threat faced by nearly 40% of the global population and the escalating resistance of parasites to current treatments. This study comprehensively addresses prevalent parasitic and viral illnesses transmitted by mosquitoes, leading to the annual symptomatic infections of 400 million individuals, placing 100 million at constant risk of contracting these diseases. Extensive investigations underscore the pivotal role of traditional plants as rich sources for pioneering pharmaceuticals. The latter half of this century witnessed the ascent of bioactive compounds within traditional medicine, laying the foundation for modern therapeutic breakthroughs. Herbal medicine, notably influential in underdeveloped or developing nations, remains an essential healthcare resource. Traditional Indian medical systems such as Ayurveda, Siddha, and Unani, with a history of successful outcomes, highlight the potential of these methodologies. Current scrutiny of Indian medicinal herbs reveals their promise as cutting-edge drug reservoirs. The propensity of plant-derived compounds to interact with biological receptors positions them as prime candidates for drug development. Yet, a comprehensive perspective is crucial. While this study underscores the promise of plant-based compounds as therapeutic agents against malaria and dengue fever, acknowledging the intricate complexities of drug development and the challenges therein are imperative. The journey from traditional remedies to contemporary medical applications is multifaceted and warrants prudent consideration. This research aspires to offer invaluable insights into the management of malaria and dengue fever. By unveiling plant-based compounds with potential antimalarial and antiviral properties, this study aims to contribute to disease control. In pursuit of this goal, a thorough understanding of the mechanistic foundations of traditional antimalarial and antidengue plants opens doors to novel therapeutic avenues.
The First Public Murder in the Tanzimat Era: Life, Trial and Execution of Emine Hanım
Authors: Şiviloğlu Murat R.
Published: October 2023

In 1860, Emine Hanım killed her husband Ferik İbrahim Pasha. In this article, I use her murder trial to examine the interrelation between slavery, the private lives of the Ottoman ruling class, and the complexities of the judicial system during the Tanzimat period (1839–1876). I identify the limitations of nineteenth-century legal reforms and the discrepancy between the reformist ideals and the real-world complexities experienced by individuals. By paying close attention to legal issues in the Ottoman Empire during the Tanzimat era, such as siyaseten katl (administrative death penalty) and the inconsistent application of kısas (retaliation in kind), I argue that Emine’s story contributes to a better understanding of the Ottoman legal system during the reform era.
A new scolebythid-like chrysidoid genus and species (Hymenoptera: Chrysidoidea) with striking metasomal structure from the mid-Cretaceous Kachin amber
Authors: ROSSE-GUILLEVIC SIMON , JOUAULT CORENTIN , BRAZIDEC MANUEL
Published: October 2023

The Cretaceous fossil record of the aculeate superfamily Chrysidoidea has been greatly enriched in the past few years, thanks especially to the abundance of available material in the late Albian-early Cenomanian amber from the Kachin state (Myanmar). We here document the discovery of a new genus and species, Thagyaminobythus martini gen. et sp. nov., from Kachin amber, emphasizing the extraordinary diversity of chrysidoid wasps in this deposit. The genus is left as incertae sedis within the superfamily because it exhibits a combination of Scolebythidae, Bethylidae and Chrysididae features. We discuss the possibility that Thagyaminobythus martini gen. et sp. nov. could retract its posterior metasomal segments and the co-occurrence of such a structure in several chrysidoid families.
A new brown lacewing (Neuroptera: Hemerobiidae) from mid-Cretaceous Myanmar amber
Authors: LI SHU-MIN , REN DONG , YANG QIANG , SHI CHAO-FAN
Published: October 2023

A new genus and species of fossil hemerobiid, Longantenna hei gen. et sp. nov., is described from the mid-Cretaceous Burmese amber. This new genus exhibits the venation characters combination of RP with only one stem and the forewing ScP and RA separated, resembling the extinct genus Hemeroberotha Makarkin & Gröhn, 2020 from the same assemblage, meanwhile it shows more differences from the other Mesozoic and Cenozoic hemerobiid genera. Besides, the ORBs variations among the extinct and extant hemerobiids are discussed.
New Jurassic protopsyllidiids from the Yan’an Formation, North China (Insecta: Hemiptera)
Authors: XU MIN-MIN , HAKIM MARINA , HUANG DI-YING
Published: October 2023

The Middle-Late Jurassic Yanliao biota is a significant paleoecosystem for the understanding of the evolution of Life during the Mesozoic. The origin, distribution, and geology of the Yanliao biota are poorly understood to date. Here we describe and illustrate two new species of protopsyllidiids, namely Sinopsocus yananensis sp. nov. and Subaphidulum sinica sp. nov. from the Middle Jurassic Yan’an Formation near Yan’an City, Shaanxi Province, North China. S. yananensis sp. nov. closely resembles the type species Sinopsocus oligovenus from the Haifanggou Formation at Beipiao City, West Liaoning, Northeast China. The new discoveries not only increase the diversity of Mesozoic protopsyllidiids but also provide thread for understanding the origin of the Yanliao biota.
Scientific analysis of ancient amber artifacts along the Maritime Silk Road
Authors: LIU QI , LIU SONG , LÜ LIANG-BO , LI XING-PING , LI QING-HUI , LIAO CHUNG-JUNG
Published: October 2023

Amber, highly prized in ancient times, has a wide range of applications. Archaeological evidence confirms that amber played a significant role in long-distance material exchange and trade during ancient times. Baltic amber, in particular, was extensively traded in the Near East region during the Bronze age (e.g., Todd, 1985). The emergence of the Silk Road trade additionally facilitated the spread of amber and its products in the Far East. Extensive archaeological excavations conducted across the Eurasian steppe (Treister, 2020), as well as in China and the Korean Peninsula, have yielded numerous amber artifacts originating from the Baltic Sea (e.g., Park et al., 2016; Xiao et al., 2020; Liu et al., 2022). The northern region of Myanmar served as a significant source of amber material in Asia during ancient times, and amber from this area and its products have also been discovered in the Han Dynasty (206 BCE–220 AD) tombs in China (Chen et al., 2019; Zhao et al., 2023; Liu et al., 2023). It is generally accepted that the ancient amber artifacts in China were primarily made from amber obtained from both the Baltic region and Myanmar (e.g., Xu, 2008). However, the scarcity of amber in Iron Age sites across South and Southeast Asia impedes tour comprehensive understanding about its usage and trade among this specific area.
An unusual artematopodid beetle from Early Cretaceous Wealden amber (Coleoptera: Elateroidea: Artematopodidae)
Authors: TIHELKA ERIK , JARZEMBOWSKI EDMUND A. , AZAR DANY , HUANG DI-YING , CAI CHEN-YANG
Published: October 2023

Early Cretaceous Wealden amber of the Isle of Wight (early Barremian, ~125 Ma) represents one of the oldest known fossiliferous ambers. Here we describe the first fossil beetle from the deposit, and first British coleopteran amber inclusion, the artematopodid Valdopogon simpsoni gen. et sp. nov. Despite its fragmentary nature, the fossil possesses a puzzling combination of characters unseen in modern Artematopodidae, namely equally long abdominal ventrites I and II, concave sutures between ventrites I–V, and absence of elytral striation. Valdopogon contributes to our understanding of the morphological evolution of this once diverse group of elateroid beetles.
Evolution of Insect Diversity in the Permian and Triassic
Authors: GUI SHUANG-MAO , LIU YU-CHU , TIAN LI
Published: October 2023

The global warming that occurred during the Permo-Triassic transition, following the end of the Late Paleozoic glaciation, and the resulting responses of the biota to the changing environment, are considered important analogs for understanding rapid future warming scenarios. While there has been extensive research on the patterns and extent of diversity in plants, tetrapods, and marine invertebrates during the Permo-Triassic, the study of insect diversity and the evolution of their faunal composition has been relatively limited. The question of whether there were insect extinctions during this period continues to be a subject of debate. Here, we present a statistical study on taxonomic diversity of insects—at specific, generic and familial levels—throughout the Permian and Triassic, with subsampled context on the reported global occurrences. Our result show that more than one insect extinction events, accompanied by significant diversity drop and turnovers of faunal compositional, occurred in the Permian and Triassic. All the uncovered insect diversity crises exhibit strong correspondence with the well-known marine mass extinction events in the Middle Permian, Permo-Triassic transition, Carnian, and Rhaetian, whilst the marine correspondence with the Early Permian insect crisis is less pronounced. Insects, being a major component of terrestrial ecosystems, demonstrate varied diversity responses to climatic changes in Permian and Triassic. Our study sheds new light on the intricate interplay between insect diversity evolution and the changing environmental conditions during these critical geohistorical periods.
Revision of the Amphibolips ‘niger’ group with the description of a new species (Hymenoptera: Cynipini)
Authors: CUESTA-PORTA VICTOR , MELIKA GEORGE , NICHOLLS JAMES A. , STONE GRAHAM N. , EQUIHUA-MARTINEZ ARMANDO , ESTRADA-VENEGAS EDITH , PUJADE-VILLAR JULI
Published: October 2023

Amphibolips is currently divided into two species-groups, clearly differentiated by adult and gall morphology. The ‘niger’ group of Amphibolips species is revised. This complex includes eight species: A. gumia Kinsey, A. jubatus Kinsey, A. elatus Kinsey, A. maturus Kinsey, A. nebris Kinsey, A. niger Kinsey, A. pistrix Kinsey and A. ufo Cuesta-Porta & Pujade-Villar sp. nov. We provide descriptions of new species and re-descriptions of known species, diagnoses, keys to complexes and species. The possibility of the ‘niger’ complex belonging to a new genus is also discussed.
Gender and Inequality in Access to Healthcare Facilities in India: Evidence from NSSO’s 75th Round on Health
Authors: Singh Harpreet , Singh Rana Amanat
Published: October 2023

The present study attempts to explore gender-based gaps in access to quality healthcare at the pan-India level. To undertake our analyses using National Sample Survey Office’s secondary data, we prepared a Gender Parity Index to understand the nature and extent of gender differential in access and direct utilization of quality healthcare services. The results validate the proposed objective of the study, that is, females suffer from innate accessibility gaps in rural as well as urban India. Females not only lack access to general healthcare but are also devoid of quality healthcare. Males, often, have better access to general healthcare through private hospitals and clinics in conjunction with other sources. On the other hand, females are predominantly confined to the government and charitable medical institutions. Additionally, the results show that the brunt of these gaps in healthcare is borne relatively more by rural females than their urban female counterparts.