bluuebunny/crossref_metadata_2025 huggingface dataset:
Social media as a contributor to conflicts in protected areas: experiences, problems, and potential solutions
Authors: Arndt Saskia
Published: December 2023

Within two decades, social media has profoundly changed modern society. The various effects of this rapid development are increasingly the subject of interdisciplinary research. For protected areas, the focus has so far been on the possibilities of social media as a means of visitor communication and monitoring. This is an exploratory study identifying case studies of protected areas where visitors’ use of social media has contributed to negative environmental effects. Furthermore, potential measures to address these challenges are provided. Data collection was conducted with a selective review of academic and non-academic literature using a global research framework and EU-wide qualitative email interviews with staff from 44 national parks. The research results were structured using the DPSIR framework of the European Environment Agency. Social media trend-driven mass tourism and dissemination of nature-damaging behaviour via social media appear to be the most pressing issues. To implement conservation measures successfully and ensure long-term conservation goals, protected area management must consider the potential negative effects of social media. As digitisation progresses, the urgency of corresponding studies and measures increases. The enhancement of digital skills and digital visitor guidance by nature conservation actors may help to counteract future negative environmental effects.
Incidence and Characteristics of the Hyperosmolar Hyperglycemic State: A Danish Cohort Study
Authors: Rosager Emilie V. , Heltø Amalia Lærke K. , Fox Maule Cathrine U. , Friis-Hansen Lennart , Petersen Janne , Nielsen Finn E. , Haugaard Steen B. , Gregersen Rasmus
Published: December 2023

OBJECTIVE

The hyperosmolar hyperglycemic state (HHS) is a rare and life-threatening complication of diabetes. We aimed to estimate the incidence of HHS and describe the clinical and biomarker profiles of patients with HHS, including subgroups with acidosis and acute kidney injury.

RESEARCH DESIGN AND METHODS

This nationwide, descriptive cohort study used Danish registry data during years 2016–2018 to identify acutely admitted patients fulfilling the hyperglycemia and hyperosmolarity criteria of HHS (glucose ≥33 mmol/L and osmolarity [2 × sodium + glucose] ≥320 mmol/L).

RESULTS

We identified 634 patients (median age, 69 years (first quartile; third quartile: 58; 79) who met the criteria of HHS among 4.80 million inhabitants aged ≥18 years. The incidence rates were 16.5 and 3.9 per 10,000 person-years among people with known type 1 (n = 24,196) and type 2 (n = 251,357) diabetes, respectively. Thirty-two percent of patients with HHS were not previously diagnosed with diabetes. Patients were categorized as pure HHS (n = 394) and combined HHS and diabetic ketoacidosis (HHS-DKA; n = 240). The in-hospital mortality rate for pure HHS was 17% and 9% for HHS-DKA.

CONCLUSIONS

The incidence of HHS was higher among patients with type 1 diabetes compared with type 2 diabetes. HHS is a spectrum of hyperglycemic crises and can be divided in pure HHS and HHS-DKA. In one-third of patients, HHS was the debut of their diabetes diagnosis.
Assessment of Glycemic Control by Continuous Glucose Monitoring, Hemoglobin A1c, Fructosamine, and Glycated Albumin in Patients With End-Stage Kidney Disease and Burnt-Out Diabetes
Authors: Kaminski Candice Y. , Galindo Rodolfo J. , Navarrete Jose E. , Zabala Zohyra , Moazzami Bobak , Gerges Amany , McCoy Rozalina G. , Fayfman Maya , Vellanki Priyathama , Idrees Thaer , Peng Limin , Umpierrez Guillermo E.
Published: December 2023

OBJECTIVE

Patients with diabetes and end-stage kidney disease (ESKD) may experience “burnt-out diabetes,” defined as having an HbA1c value <6.5% without antidiabetic therapy for >6 months. We aim to assess glycemic control by continuous glucose monitoring (Dexcom G6 CGM) metrics and glycemic markers in ESKD patients on hemodialysis with burnt-out diabetes.

RESEARCH DESIGN AND METHODS

In this pilot prospective study, glycemic control was assessed by continuous glucose monitoring (CGM), HbA1c measures, and glycated albumin and fructosamine measurements in patients with burnt-out diabetes (n = 20) and without a history of diabetes (n = 20).

RESULTS

Patients with burnt-out diabetes had higher CGM-measured daily glucose levels, lower percent time in the range 70–180 mg/dL, higher percent time above range (>250 mg/dL), and longer duration of hyperglycemia >180 mg/dL (hours/day) compared with patients without diabetes (all P < 0.01). HbA1c and fructosamine levels were similar; however, patients with burnt-out diabetes had higher levels of glycated albumin than did patients without diabetes.

CONCLUSIONS

The use of CGM demonstrated that patients with burnt-out diabetes have significant undiagnosed hyperglycemia. CGM and glycated albumin provide better assessment of glycemic control than do values of HbA1c and fructosamine in patients with ESKD.
Advances in Clinical Toxicology depend on Ecotechnology
Authors: Datta Subhas Chandra
Published: December 2023

The oldest enriched habitat of the Banka-Siphon-Dam (BSD) of Banka River (BR) attached to Eden Canal (EC) of Damodar River (DR), Kanchannagar, Burdwan, West Bengal India, covering a 3-5 sq km area with different flora- and faunal diversity with agricultural fields and dense vegetation forty-five years ago. But it was decreasing gradually up to December 2019 due to massive visitors or tourists, picnic parties with large sound systems, irregular fishing, killing wild animals, cutting the trees, disturbing and catching different animals including migratory birds, unethical human behaviors, and urbanization nearby badly affected on ‘Advances in Clinical Toxicology’. On the other hand, the Covid-lockdowns also impacted the ecosystem health during the pandemic coronavirus-disease (COVID-19), it has also faced social and economic challenges among the communities, and health systems-“the invisible patients”, due to hampering truism and education, and suspicious killing or catch or death of grey-coloured water monitor lizards, fishing cats, civet cats, and barn owls, and even migratory birds also. And has lost the ecological balance of water, land and vegetation (micro bio-climate) with an increased viper snake, rodent population, etc. And adversely affect the environment (Water, Sanitation and Ecology) and societal problems. To overcome, it is therefore, augments and confirms that propagation of the artificial nests, awareness, plantation of different fruits plants, and cultivations would be beneficial to do away with the rodent menace primarily, and inhibit the damage and economic losses, without putting any severe implications on the sustainability of pisciculture-fishery agro-ecosystems of the “Banka-Siphon Eden-Canal of Damodar May be Develop as ‘Biodiversity-Biomedicines-Hub for Advances in Clinical Toxicology Depend on Eco-technology’ Improving World Policy”. And the perfect ecological balance of water, land and vegetation may develop any ‘Future-Socioeconomically-Ecological-Tourist-Hub with Advances in Clinical Toxicology Eco-Technology Hub’
Occupational Cancer, What about Informal Workers in the Agriculture Sector? The Case of Chile
Authors: Ramírez Claudio Müller
Published: December 2023

We raise our concern about cancer risks associated with occupational activities performed by Chilean workers in the agriculture sector. It is known that long term occupational exposures to many chemicals and agents (e.g. pesticides, ultraviolet radiation, diesel-combustion and silica-based particulate matter), present in the agriculture sector increase the probability of developing cancer (e.g. lung and breast cancer, myeloid leukemia) among workers
Animal Models Used for Bioavailability and Bioequivalence Studies: Focus on Their Human Likeness
Authors: P Sudhakar
Published: December 2023

Bioequivalence (BE) and bioavailability (BA) studies are important for the development of new drugs and their approval by regulatory agencies. To determine the safety and efficacy of a drug, it is necessary to evaluate its bioavailability and bioequivalence. In vivo preclinical studies of BEBA are needed to explore the pharmacokinetic properties and behaviour of drugs. The in vivo BEBA studies data helps to get the proximate pharmacokinetic human values for clinical studies. The selection of animal models for BEBA studies plays a crucial role, which should mimic the anatomical and physiological state of humans. In this study, we have extensively reviewed the commonly used animal models for BEBA studies i.e. rodents, rabbits, canines, pigs, and non-human primates, and their relevance with human physiology. Besides the selected models rats have similar absorption, distribution, metabolism, and excretion profile to humans. Beagle dogs are an alternative commonly used in the study of oral bioavailability, as they share many similarities with humans in terms of gastrointestinal anatomy and physiology. This extensive review provides valuable information about the selection of proper animal models for BEBA studies
Assessing the Effectiveness of Helfer Skin Tap Technique on Pain Reduction among Children Undergoing Intramuscular Vaccination in FLACC Numerical Pain Scale
Authors: S Mishra
Published: December 2023

Introduction: Intra muscular vaccination is complex technique used to deliver vaccines among children deep into the large muscles of the body. Pain at injection site is one of the most commonly-reported local reactions associated with administration of a vaccine. It is more painful when combination of more than two vaccines injected at a time among children. Pain management in invasive procedure is a challenge to the nurse. Hence, complementary therapy like Helfer skin tap technique has its own significance and provides a mechanical stimulation and distraction during intramuscular vaccination and thus helps to decrease pain as described by gate control theory which keeps the muscles relaxed while administering IM injection. Objective: A study to assess the effectiveness of Helfer skin taps technique on pain reduction among children undergoing intramuscular vaccination at district hospital Waidhan, Singrauli. Method: The study involved quasi experimental posttest only design with non-probability purposive sampling method. The data was collected from 60 Children’s undergoing intramuscular vaccination. Intervention: In Helfer skin tap technique Intramuscular vaccination is done by tapping to the injection site by using palmer aspect of the hand about three times and inserting the needle without the feeling of pain and removing the needle by tapping the area again three times. Tools: Standardized FLACC 0-10 numerical pain scale used to assess the pain reduction among children undergoing intramuscular vaccination. Results: The data collected was analyzed using descriptive and inferential statistics. The study shows using standard technique in control group 27 children had moderate pain (90%), 3 children had severe pain (10%) while in experimental group 17 had moderate pain (57%), 8 had severe pain (26%) and 5 had mild pain (17%). Analysis among experimental group by using paired‘t’ test found significant value 5.94 at p<0.05 level. The study shows that after the procedure observation intramuscular vaccination is less painful in experimental group as compare to control group among children. Interpretation & Conclusion: The study shows that Helfer skin tap technique was more effective on pain reduction undergoing intramuscular vaccination than the usual standard technique used among children.
Bioequivalence, Bioequivalence Parameters, Study Types and Situations Which Are/Not Necessary
Authors: YILMAZ İsmet
Published: December 2023

In this review, short definition of bioequivalence, study types and situations which is/not necessary have been summarized. In the world, it is realized that the most valuable quality control testing is bioequivalence studies and the results of bioequivalence studies have been used as an important indicator by the authors of the subject.
Formulation and Characterization of Solid Lipid Nanoparticles for Topical Delivery of Antibacterial Drug
Authors: AK Pandey
Published: December 2023

The aim of this study was to prepare and evaluate solid lipid nanoparticles for the skin delivery of Ciprofloxacin. Ciprofloxacin loaded solid lipid nanoparticles (SLNs) have been successfully developed by using a microemulsion technique. Three different formulations were prepared It was found that variation in the amount of ingredients had profound effects on the Ciprofloxacin loading capacity, mean particle size, size distribution of charge, morphology, and drug-lipid compatibility. At optimized process conditions, Ciprofloxacin loaded SLNs showed spherical particles with a mean particle size of 250 ɳm and 60% Ciprofloxacin incorporation efficacy was achieved. The SLN sustained the drug release for 6 h in vitro. The results suggest formulation could be used as a potential topical formulation for fungal infection.
Bioequivalence Study of Salbutamol 400 mg Tablet in Healthy Indonesian Volunteers by Liquid Chromatography Tandem with Mass Spectrometry
Authors: P Priyanto
Published: December 2023

This study objective was to determine the bioequivalence of Salbutamol 4 mg Tablet manufactured by PT Kimia Farma Tbk compared to Ventolin® 2x2 mg Tablet manufactured by Glaxo Wellcome Indonesia, in healthy Indonesian volunteer. The pharmacokinetic parameters calculated in this study are AUC0-24, AUC0-inf, Cmax, Tmax, and T1/2. The study was conducted in a randomized, single-dose, open-label, two-way crossover design (2 treatments, 2 periods, and 2 sequences) under fasting state with 7 (seven) days washed-out period. The number of subjects who participated in the study were 24 volunteers ((12 males and 12 females). The participants were provided with an overview of the study and signed the informed consent form. The study participants underwent a minimum 8-hour fasting period prior to receiving both the test drug and the reference drug, and blood samples were collected at 14 specified time points: 0 hours (before drug administration), minutes-20, minutes-40, 1, 1.5, 2, 2.5, 3, 4, 6, 8, 12, 16, and 24 hours after drug administration. Plasma concentrations of the drug were determined by LCMS/MS method. The acceptance criteria for the bioequivalence test are 80.00 - 125.00% for AUC0-t and Cmax with 90% Confidence Interval (CI) with α = 5.00%. The mean SD value of AUC0-24, AUC0-inf, Cmax, Tmax, and T1/2 respectively for test drug is 84.49 ±18.99 ng.mL-1.hour; 89.66 ±21.29 ng.mL-1.hour; 13.85 ±4.25 ng/mL; 2.00 ±0.71 hour and 5.08 ±1.27 hour. The mean SD values of AUC0-24, AUC0-inf, Cmax, Tmax, and C1/2 respectively for reference drug are 88.81 ±26.50 ng.mL-1.jam; 93.78 ±27.97 ng.mL-1.jam; 13.39 ±5.39 ng/mL; 2.63 ±1.45 hour and 5.03 ±1.16 hour. Meanwhile, the geometric mean ratio of test drug to reference drug (90% confidence interval) is 96.35% (90.55- 102.53%) for AUC0-24 and 105.39% (93.62-118.65%) for Cmax. Based on the AUC0-24 and Cmax values, Salbutamol 4 mg Tablet manufactured by PT Kimia Farma Tbk is bioequivalent to Ventolin® 2x2 mg Tablet manufactured by Glaxo Wellcome Indonesia.
Cost-Effectiveness Analysis of Biologics in the Treatment of Moderate-to-Severe Plaque Psoriasis from a Health Care Provider's Perspective
Authors: J Duda
Published: December 2023

Introduction: Psoriasis (psoriasis) is a chronic disease with a number of significant comorbidities and often with a very significant impact on the quality of life of patients. Recently, a relatively large number of biological treatment products with a significant effect have entered the market, but they are also significantly more expensive than systemic conventional treatment. In the context of the published long period of inadequate treatment of patients with psoriasis in the Czech Republic, the health care system and the limited costs of center drugs, it is necessary to make the greatest possible effort at the level of the provider of this health care to effectively spend financial resources and provide highly effective treatment to the greatest possible number of patients. Method: With a model-set amount of the unit prices of the packaging of preparations according to the maximum reimbursements in the Czech Republic in 2021, a fictitiously set amount of bonuses for only two selected preparations (this is a model example that does not reflect the real state of business policy at the University Hospital Olomouc), and the conditions for reimbursement of biological treatment preparations psoriasis in the Czech Republic in 2021, a cost-effectiveness analysis (CEA) was carried out in the selected PASI 100 efficiency parameter. The analysis was carried out and processed interactively in the Excel software into the graphical form of the outputs, especially in the form of forest plot graphs (in the CER and ICER parameters) and in a two-dimensional efficient frontiers graph (costs vs. efficiency). Results: The differences in the cost-effectiveness of individual preparations according to the point values of the CER and ICER parameters are up to several times. Taking into account the 95% confidence intervals, some of the differences between the preparations are also statistically significant. With the most cost-effective sequence of treatment for a gradually more effective drug in one patient during the induction period of treatment, we can, based on the saved costs, start induction treatment with a less effective biologic in two more patients than when using the second cost-effective sequence of treatment escalation. Conclusion: The cost-effectiveness analysis (CEA) of biological drugs in the treatment of psoriasis at the level of the health service provider has great potential in the effort to make the treatment as effective as possible with limited financial resources, or in the effort to provide effective treatment to additional patients with the same limitations
Nanotechnology as a Tool to Improve the Biological Activity of Thymol: A Review
Authors: B Mittu
Published: December 2023

Thymol is a naturally occurring compound found in the essential oils of thyme, oregano, and other plants. It has been shown to have a variety of pharmacological activities, including antimicrobial, antioxidant, and anti-inflammatory properties. In recent years, researchers have investigated the potential of thymol as an anticancer agent. However, thymol has limited solubility and poor bioavailability, which limits its use as a therapeutic agent. To overcome these limitations, researchers have developed various nano-based drug delivery systems (NDDS) to improve the efficacy of thymol. In this article, we will review the current state of research on thymol NDDS with anti-tumor activity.
Correlation of Fructosamine and HbA1c (Glycosylated Haemoglobin) in Type 2 Diabetes Mellitus Patients with Chronic Kidney Disease
Authors: S Ahmad
Published: December 2023

Background: In 2015, India had 69.2 million diabetes and 36.5 million impaired Glucose Tolerance (IGT) people (20-79yrs) which are expected to rise to 123.5 million and 63.6 million by 2040 respectively. Therefore need for assessing correct glycemic status of patients of Diabetes Mellitus as well as Diabetes Mellitus patients with CKD at correct time becomes necessary. Use of Fructosamine for the analysis of blood glucose levels might give better, comparatively fast results in these patients. Aims: The purpose of this study was to find out the correlation between Fasting Blood sugar, Fructosamine and HbA1c( Glycosylated haemoglobin) in patients of Type 2 Diabetes Mellitus with and without kidney disease Method: A total of 100 patients were taken and divided into 2 groups: Group A (n=50) – Patients with Diabetes Mellitus and Group B (n=50)- Patients with Diabetes Mellitus and Chronic Kidney Disease. 50 healthy controls (without DM and CKD) were taken. Result: Mean value of Fasting blood glucose in Group A – 186mg/dL SD- 52.2; Group B-182mg/dL, SD - 49.4. (t=0.781, p=0.437).The patients with DM and CKD (Group B) had lower levels of mean HbA1c (6.93%) as compared to Group A (DM), mean HbA1c -8.4%.There was significant difference between the groups (t=5.396, p<0.001). The mean of Fructosamine in Group A-439, SD-127 , Group B-421,SD-112.(t=0.757,p=0.451).Our study also showed that in different stages of CKD ,there was no statistical difference between Fructosamine and HbA1c (HbA1c Vs GFR: r= - 0, 038, p=0.817, Fructosamine Vs GFR :r= -0.057, p=0.726). Conclusion: Serum Fructosamine is superior to HbA1c in assessing blood glucose control in Diabetes Mellitus patients with CKD.
Talon Cusp, Tooth Transposition, Taurodontism-Occurrence of “T Anomalies” Together in a Non-Syndromic Child-A Rarest Case Report
Authors: NB Nagaveni
Published: December 2023

Presenting of rare and unusual dental anomalies is always essential to enhance the richness of existing dental literature pertaining to these anomalies. Developmental dental anomalies starting from the alphabet ‘T’ such as Talon cusp, Transposition and Taurodontism are the uncommon dental phenomenon’s which are reported individually. However, occurrence of all these anomalies together is not reported so far. Therefore, the purpose of the present article is to report occurrences of all these dental anomalies together in detail in a 9-year-old, normal, healthy Indian male patient.
Herbal Egyptian Plants: Siddr Tree (Ziziphus spinachristi L.) Instead of (Herbal Egyptian Plants Siddr Tree (Ziziphus spinachristi L.))
Authors: Abobatta Waleed Fouad
Published: December 2023

Siddr tree (Ziziphus spinachristi L.) has been grown in Egypt since ancient times; Pharos planted the tree in the Nile valley over a long period of time, and it is still growing in Egyptian gardens today, particularly in Upper Egypt (Figure 1).
Review on the Water Quality Status of Lake Hawassa, Central Rift Valley Lakes, Ethiopia
Authors: Daniel Muluken
Published: December 2023

Population growth, urbanization, and modernization are all contributing to sewage disposal issues and lake poisoning. The physical, chemical, and biological properties of water are typically used to describe its quality. Numerous factors, including BOD, temperature, electrical conductivity, nitrate, phosphorus, potassium, dissolved oxygen, etc., can be used to measure the quality of water. Because they pollute water or induce chronic poisoning in aquatic creatures, heavy metals like Pb, Cr, Fe, and Hg are particularly concerning. This review study stresses the Lake Hawassa water quality status using various research findings from both published and unpublished web documents. It was noted that the water from Lake Hawassa is extremely contaminated and may not meet the requirements for drinking and recreational uses, although with great care, it benefits aquatic life and irrigation. Pesticides were found in significant concentrations in Lake Hawassa's water, sediments, and fish species as a result of its exposure to effluent from industrial, urban, and agricultural runoff. As a result, the lake has become poisoned, threatening the aquatic ecosystem's biodiversity, which includes fish. Therefore, in order to protect Lake Hawassa's water supply, the government should implement the necessary controls to prevent the discharge of pollutants from agricultural fields, ceramics, textiles, plastics, urban storm water, leather tanning, and food processing sectors.
Assessing Genetic Variability in Wheat (Triticum aestivum L.) Under Timely and Late Sown Conditions for Tolerance Towards Terminal Heat Stress
Authors: Karla Uttej , Choudhary Vinay Kumar , Singh Satish Kumar , Vignesh S. , Ellandula Anvesh
Published: December 2023

A field experiment was conducted at wheat experimental farm, Post Graduate College of Agriculture, DRPCAU, Pusa, Bihar to quantify the genetic variability among twenty-nine wheat genotypes under timely and late sowing conditions for tolerance towards terminal heat stress during rabi 2020–2021.  The trial was performed in three replications using Randomized Block Design. The study included estimates of genetic variability parameters such as mean, range, phenotypic coefficient of variability, genotypic coefficient of variability, broad-sense heritability, and genetic advance over % of mean. The ANOVA estimations showed that there’s considerable variation across genotypes for all twelve traits investigated across both environments. Traits like grains spike-1 and harvest index displayed considerable genotypic and phenotypic variances across both environments indicating the relevance of these traits in stress conditions. Tillers plant-1 and grain yield plant-1 displayed high genotypic and phenotypic coefficient of variation in timely and late conditions respectively. High heritability reported for traits like days to 50% flowering, canopy temperature, harvest index, grain yield plant-1, tillers plant-1, thousand grain weight and grains spike-1 in both conditions. Under both conditions, tillers plant-1, grains spike-1, harvest index and grain yield plant-1 reported strong heritability along with high genetic advance over % of mean. As a result, direct selection may be made using these features for further genotype improvement under stress conditions for improved heat tolerance.
Characterization and Evaluation of Different Cultivars of Sapota (Manilkara achras L.) under the Gangetic Plain of West Bengal
Authors: Mondal Tanmoy , Mahata Subrata , Bauri Fatik Kumar , Mandi Gouri , Mishra Dilip Kumar
Published: December 2023

The present experiment was carried out in Bidhan Chandra Krishi Viswavidyalaya, Mohanpur, Nadia, West Bengal during April to June of 2022 to find out the best cultivars of this region. The experiment was laid out in Randomized Block Design (RBD) with seven treatments each replicated thrice. The ten years old seven cultivars (Cricket Ball, PKM-1, PKM-2, PKM-3, CO-1, CO-2 and CO-3) are planted in a square system in a spacing of 5×5 m2. The maximum fruit weight was found in CO-1 (73.86 g) and followed by CO-2 (73.53 g). The longest fruit length and dimension were observed from CO-2 (7.00 cm and 5.07 cm respectively). The maximum pulp contains in the cultivar is CO-2 (69.58 g) followed by CO-1 (68.96 g). The maximum value of TSS was found in CO-2 (25.17 oBrix) followed by Cricket Ball (21.22 oBrix) and CO-3 (20.28 oBrix). The lowest acidity was recorded in CO-2 (0.12%) followed by CO-3 (0.16%) and CO-1 (0.20%). The cultivar CO-2 registered the highest values of ascorbic acid (62.85 mg 100 g-1), total sugar (16.78%), non-reducing sugar (6.44%) and TSS: acid ratio (209.72). It can be concluded that CO-2 appeared to be the best variety based on the fruit’s physical and quality attributes. As this experiment was carried out based on a limited number of varieties, more research was required on the existing germplasm of India. That might be supported in sapota’s future production, processing, and marketing.
Pengaruh jalinan lalu-lintas terhadap tundaan di Jalan Imam Bonjol dengan metode gap acceptance
Authors: Rama Muhammad Ichsan Syaditya , Junaedi Tas’an , Sulistyorini Rahayu
Published: December 2023

Di Jalan Imam Bonjol terdapat jalinan simpang dari Jalan Mangkubumi ke Jalan Sultan Badarudin, yang pada saat jam sibuk menyebabkan kemacetan dengan antrian yang panjang dan lamanya waktu tundaan. Oleh sebab itu, penelitian ini bertujuan untuk menganalisis tundaan menggunakan metode gap acceptance dan mengetahui tingkat pelayanan di simpang Jalan Imam Bonjol. Beberapa karakteristik di simpang yang di analisis adalah kecepatan, gap, gap kritis dan tundaan. Hasil penelitian  menunjukkan ke-cepatan kendaraan sangat terpengaruh oleh weaving menyebabkan kecepatannya lebih rendah. Selain itu, besarnya rata-rata tundaan di pagi hari sebesar 42,3 detik dan di sore hari sebesar 52,8 detik pada interval waktu tiap 5 menit, sehingga tingkat pelayanan simpang pada Jalan Imam Bonjol adalah E. Setelah solusi pelebaran jalan 0,5 m per lajur disimulasikan menggunakan software vissim, didapatkan tingkat pelayanan simpang menjadi B.
Antibacterial Potential of Chitosan Scaffolds Incorporated with Oregano and Thyme Essential Oils against Escherichia coli
Authors: Torres José Lucas Medeiros , Silva Sonaly de Lima , Medeiros Maria Alice Araújo de , Alves Millena de Souza , Bezerra Márcia Maria de Siqueira Leite , Mariz Waldo Silva , Oliveira Elaine Bezerra de , Silva Emanoel Vitor Alves da , Guênes Gyselle Tenório , Guênes Gymenna Maria Tenório , Medeiros Luanna Abílio Diniz Melquíades de , Fook Marcus Vinicius Lia , Sousa Wladymyr Jéfferson Bacalhau de , Oliveira Filho Abrahão Alves de
Published: December 2023

The aim of this study was to evaluate the antibacterial potential of chitosan-based scaffolds associated with the essential oils of Origanum vulgare L. and Thymus vulgaris L. against a strain of Escherichia coli. The antibacterial potential was assessed by reading the inhibition halos formed around the chitosan-based scaffolds incorporated with thyme EO, oregano EO and thyme and oregano EO against the Escherichia coli strain, using the Mueller Hinton agar diffusion methodology per well. To do this, Mueller Hinton Agar was used as the culture medium in Petri dishes, and holes 6 mm in diameter were formed using a mold to create the wells. The plates were inoculated with the microorganism using a swab, then incubated in a bacteriological oven at 37 °C for 24 hours. Scaffolds, in the form of disks, were aseptically deposited in the wells of the inoculated media, which were incubated at 37 °C for 24 hours. After incubation, the plates were observed for homogeneity of bacterial growth and the diameter of the inhibitory halo was measured using a millimeter ruler in cases where inhibition of bacterial growth was verified. The tests were carried out in duplicate and the results correspond to the average values. The association of chitosan with Origanum vulgare L. and Thymus vulgaris L. EOs was found to have antibacterial activity against the Escherichia coli strain. For the scaffolds incorporated with Origanum vulgare L. EO, Thymus vulgaris L. EO and associated Origanum vulgare L. and Thymus vulgaris L. EOs, 16 mm inhibition halos were formed against the Escherichia coli strain. The association of chitosan with the EOs of Origanum vulgare L. and Thymus vulgaris L. has antibacterial activity, acting as a bactericide against the Escherichia coli strain tested.
Analisis Kesetaraan Gender Terhadap Pembangunan Perekonomian Daerah Wilayah Pro Gender di Kabupaten/Kota Sumatera Barat
Authors: Farazila Erra , Riani Novya Zulva , Rahmizal Maizul
Published: December 2023

This study was conducted to determine how gender equality in the fields ofeducation, health, and per capita expenditure on the economy of pro-genderregions in districts / cities in West Sumatra. This type of research isquantitative research, the data used is panel data, namely from 19 districts /cities in West Sumatra in 2017-2022, which is secondary data obtained fromthe Central Statistics Agency (BPS). The results showed that: 1) theclassification of gender equality in the field of education on the regionaleconomy there are 9 regions in developed areas that are pro-gender, 2 regionsin potential areas that are pro-gender, 4 in developing areas that are not progenderand 4 regions in underdeveloped areas that are not pro-gender. 2) Theclassification of gender equality in the health sector has the results that thereare 6 regions in developed areas that are pro-gender, 6 regions in potentialareas that are pro-gender, 7 regions in developing areas that are not progenderand there are no regions in underdeveloped areas that are not progender.3) The classification of gender equality in the field of per capitaexpenditure has the results of 7 regions in developed areas that are pro-gender,1 region in a potential area that is pro-gender, 6 regions in developing areasthat are not pro-gender and 4 regions in underdeveloped areas that are notpro-gender.
Kajian Organologi Pembuatan Gitar Akustik Solid Steel String Model Dreadnought Produksi GuitarUs Klaten
Authors: Setyawan Dwi , Kiswanto
Published: December 2023

Purpose: This study aims to describe the process of making a solid steel string Dreadnought acoustic guitar produced by GuitarUs and describe the characteristics of this acoustic guitar based on three aspects of sound, playability and craftsmanship, which later this data can be used as a reference in choosing a good quality steel string acoustic guitar. Method: this research uses qualitative research with a grounded theory approach, namely valid, objective and reliable research results presented by researchers based on a combination of observational data extracted from several GuitarUs luthier partners with observational data obtained from GuitarUs. Results and Discussion: The results of the research obtained are that a good, quality Dreadnought solid steel string acoustic guitar must meet the requirements for the three aspects of sound, playability and craftsmanship, which requirements can be fulfilled if in carrying out the production process, a luthier must apply the knowledge of organology and steel string acoustic guitar acoustics.
АССОЦИАЦИЯ ПОЛИМОРФНЫХ ВАРИАНТОВ ГЕНОВ HHIP, ADRB2 И ИЛ-33 С КЛИНИЧЕСКИМИ ПРОЯВЛЕНИЯМИ БРОНХИАЛЬНОЙ АСТМЫ У ДЕТЕЙ
Authors: Алиева Юлия , Фурман Евгений , Кондратьева Елена , Лошкова Елена , Шелудько Валерий , Соколовский Владимир , Хузина Екатерина , Пономарева Мария , Айшауова Раушан
Published: December 2023

Проведенное исследование полиморфизмов генов HHIP, ADRB2 и IL-33 у детей, страдающих БА, с разными фенотипами заболевания выявило ассоциацию между полиморфизмами генов и тяжестью заболевания, а также с сопутствующими заболеваниями.

Показано, что генотип ТТ генетического варианта rs12504628 (T>C) гена HHIP снижает риск реализации тяжелой БА, однако увеличивает в 2,8 раза риск сочетанного с БА атопического дерматита. Генотип СС+СТ гена HHIP в 2,9 раза увеличивает риск реализации лекарственной аллергии на фоне БА.

Генотипа АА гена ADRB2 ассоциирован со снижением риска реализации врожденных пороков развития трахеобронхиального дерева на фоне БА. Полиморфные варианты в 4 и 6 экзонах гена IL-33 чаще сочетаются со среднетяжелой и тяжелой астмой, а замены нуклеотидов в экзонах 4 и 6 ассоциированы с тяжелым течением БА.

Таким образом, в данном исследовании установлены ассоциации полиморфных вариантов генов HHIP, ADRB2 и IL-33 с клиническими проявлениями бронхиальной астмы у детей, которые могут учитываться при персонализированном наблюдении за этими пациентами, и могут помочь в достижении полного контроля над заболеванием.
Analisis Faktor- Faktor Yang Memotivasi Mahasiswa Dalam Berinvestasi Saham Pada Aplikasi Ajaib (Studi Kasus Pada Mahasiswa Universitas Muhammadiyah Metro)
Authors: Japlani Ardiansyah , Dupri Muhammad Demsi , Anita Ria
Published: December 2023

Adequate knowledge of the correct investment methods is crucial to avoid losses wheninvesting in stock market applications, such as Ajaib. The growth of investors in Ajaib'sapplication is considered quite good. However, when compared to other countries, theinvestment awareness among the Indonesian population is still relatively low. The presenceof numerous new companies can be one of the driving factors for increasing the number ofinvestors, especially in stock market investments through Ajaib's application. However, thesheer number of companies alone may not significantly impact the growth of investors if theawareness of investment among students remains low. The purpose of this research is todetermine the combined influence of interest, profit, and self-efficacy on stock marketinvestments through Ajaib's application among students at Muhammadiyah University Metro.This research uses a quantitative approach, and the research method involves the Slovin formula for sample determination. The sample consists of 56 students from the 2018 class inthe Faculty of Economics and Business at Muhammadiyah University Metro. The dataanalysis techniques include validity testing, reliability testing, normality testing, linearitytesting, and homogeneity testing. The analytical model used in this research includes multiplelinear regression analysis, T-test, F-test, and R-squared determination. Based on theresearch results, the T-test indicates that interest significantly influences stock marketinvestments through Ajaib's application among students at Muhammadiyah University Metro.Profit also has a significant influence on stock market investments through Ajaib'sapplication among these students. On the other hand, self-efficacy does not have a significanteffect on stock market investments through Ajaib's application among students atMuhammadiyah University Metro. The F-test results show that interest, profit, and selfefficacy together have a significant influence on stock market investments through Ajaib'sapplication among students at Muhammadiyah University Metro
Pengaruh Etika Kerja Islam, Hubungan Antar Karyawan, Dan Lingkungan Kerja Terhadap Kinerja Karyawan Dengan Komitmen Organisasi Variabel Mediasi Pada Rumah Sakit Islam Metro
Authors: Riyanto Kuncoro Budi , Dupri Muhammad Demsi , Safitri Djihan
Published: December 2023

This study aims to determine the quality control data on the risk of product damage at PTSurya Tsabat Mandiri in reducing the risk of product damage. The type of research used isqualitative using statistical tools contained in Statistical Data Quality Control (SQC) andStatistical Process Control (SPC). The results showed that the bread production process ofPT Surya Tsabat Mandiri in January 2020 every day there were data that were notstatistically controlled and needed to be revised 1 time. This can be seen from the out ofcontrol points that occurred on the 2nd, 5th, 7th, 9th, and 25th days. Then corrective actionis taken by looking for the causes of defects so that the points that are out of control arewithin the control limits of UCL and LCL (in of control) so that the production process canbe said to be statistically controlled.
Pengaruh Kualitas Layanan Dan Fitur Terhadap Minat Penggunaan Berkelanjutan Mobil Banking BRI Dengan Kepuasan Pengguna Sebagai Variabel Intervening (Studi Pada Mahasiswa Universitas Muhammadiyah Metro Pengguna M-Banking BRI)
Authors: Ratmono Ratmono , Yateno Yateno , Putri Annisa Nanda
Published: December 2023

Bank Rakyat Indonesia (BRI) presents a banking application called BRI Mobile (BRIMo).The use of the Mobile Banking application also encountered various obstacles including thequality of the services provided in the application and related to features that can meet theneeds of customers in conducting financial transactions. This study aims to determine theeffect of service quality and features on interest in sustainable use with user satisfaction asan intervening variable for students using BRI Mobile Banking at Muhammadiyah MetroUniversity. The research design is quantitative research or verification research. Thevariables in this study are service quality, features, satisfaction and interest in continuoususe. The population and sample of the study were students of the Management StudyProgram, Faculty of Economics and Business, University of Muhammadiyah Metro Batch2018 with the number of samples taken as many as 68 students. Data collection techniquesusing questionnaires. The analytical tools used are data quality analysis and Path Analysiswith the SPSS program. The results showed that service quality, features and satisfactionpartially had a positive and significant effect on the interest in sustainable use. Satisfactiondoes not significantly increase the effect of service quality and features on interest insustainable use.
Analisis Efektivitas Arus Kas Sebagai Upaya Mengelola Piutang Tak Tertagih Dan Likuiditas Pada PT. Federal International Finance Kota Metro
Authors: Zanaria Yulita , Darmayanti Elmira Febri , Helmi Masdar
Published: December 2023

Cash flow, is an economic activity that is differentiated from the cash flow statement, whichis reported in the high balance sheet. Cash flow is usually not used to increase the cashaccount, but is used to pay dividends, increase inventory, fund trade receivables. Thisresearch aims to determine the effectiveness of managing cash receivables, determine theeffectiveness of cash flow policies and NPL policies in managing bad debts. The method usedis a quantitative method. Data collection techniques consist of observation, interviews andcompany data. Manage receivables with asset ratios and profitability ratios. The results ofthe research show that, the accumulation of the company's trade receivables indicates a lackof effectiveness in managing trade receivables and in the end the buildup of trade receivablescan hinder the acquisition of profitability ratios and high receivable turnover is acceptablefrom a liquidity perspective and can lead to higher returns on assets. tall.
Reaksi Pasar Modal Sebelum Dan Sesudah Munculnya Financial Technology (Fintech) Peer To Peer (P2P) Lending Pada Bank Yang Terdaftar Di Bursa Efek Indonesia
Authors: Febriyanto Febriyanto , Ali Karnila , Raniana Vina
Published: December 2023

The development of innovation in the financial sector, namely fintech, fintech is an abbreviation of financial technology or financial technology. The existence of financial technology has made one of the fastest growing business sectors in the technology sector. With the development of technology and the increase in start-up companies, the development of fintech in Indonesia. Finance in Indonesia has shifted due to a format that can produce solutions and make it easier for consumers, namely the combination of economy and technology (fintech). The purpose of this study is to determine whether there are differences in trading volume activity and abnormal returns on the cooperation between banks listed on the Indonesia Stock Exchange and peer to peer P2P lending financial technology. This study uses secondary data from third-party publications with a total sample of 4 companies. The data analysis technique used is the even study data analysis, normality test and paired t-test hypothesis testing. Based on the research results, there is no significant difference in the volume of stock trading activity (trading volume activity) before and after the collaboration between peer to peer lending financial technology and banks listed on the Indonesia Stock Exchange, there is no significant difference in abnormal returns before and after the existence of cooperation between financial technology peer to peer lending to banks listed on the Indonesia Stock Exchange.
Pengaruh Kepercayaan, Keamanan Transaksi, Harga, Kualitas Pelayanan, Dan Persepsi Akan Risiko Terhadap Keputusan Pembelian Pada Konsumen E-Commerce Shopee Studi Pada Mahasiswa Fakultas Ekonomi Dan Bisnis Universitas Muhammadiyah Metro
Authors: Widodo Deny Edy , Ratmono Ratmono , Mustakim Rahmat
Published: December 2023

The development and progress of information technology is currently growing very rapidlyand is very influential in everyday life, especially life in Indonesia. All of this can be seenfrom the large and large number of internet users in Indonesia, there must be a reason, oneof which is the development of infrastructure and the second is easy to get gadgets at lowprices. This study aims to 1) To find out whether there is an influence of trust on purchasingdecisions on Shopee E-commerce consumers on students at the University of Muhamadiyah Metro. 2) To find out whether there is a security effect on purchasing decisions on Shopee Ecommerce consumers at the University of Muhamadiyah Metro students. 3) To find outwhether there is an effect of price on purchasing decisions on Shopee E-commerceconsumers at the University of Muhamadiyah Metro students. 4) To find out whether there isan effect of service quality on purchasing decisions for E-commerce consumers throughShopee for students at the University of Muhammadiyah Metro. 5) To find out whether thereis an effect of perception of risk on purchasing decisions on Shopee E-commerce consumersfor students at the University of Muhammadiyah Metro. 6) To find out whether there is aneffect of trust, security, price, service quality, and perception of risk on purchasing decisionson Shopee E-commerce consumers at Muhamadiyah Metro University students... In thisstudy, the population was FEB students, Muhammadiyah University Metro Teknik samplingusing accidental sampling with a total sample of 72 people. Data collection techniques usinga questionnaire with a Likert scale. The results show that 1) there is a positive and significantinfluence between trust on purchasing decisions. 2) there is a positive and significantinfluence between security on purchasing decisions. 3) there is a positive and significanteffect of price on purchasing decisions 4) there is a positive and significant influence on thequality of service on purchasing decisions 5) there is a positive and significant influence onthe perception of risk on purchasing
Pengaruh Brand Ambassador “Tasya Farasya” Dan Brand Trust Terhadap Minat Beli Avoskin Di Aplikasi Instagram Pada Mahasiswa
Authors: Nurmarisma Chalida , Savitri Citra , Fadilla Syifa Pramudita
Published: December 2023

The cosmetics industry is expanding extremely quickly, and in Karawang Regency, fans andconsumers of cosmetics bearing the Avoskin brand have started to rise sharply. The goal ofthis study was to evaluate and quantify the impact of Tasya Farasya as a brand ambassadorand consumer interest in purchasing cosmetics bearing the Avoskin brand. The research isquantitative in nature. The quantitative approach method is the one used. The authors usedGoogle Forms to disseminate online surveys as part of the data gathering procedure. 96samples were utilized in the analysis. The analysis employed descriptive analysis withmultiple regression using SPSS version 21. The sampling approach used non-probabilitysampling technique. Brand ambassadors have a good and substantial impact on purchaseintention, according to the study's findings. Purchase intention is positively and significantlyimpacted by brand trust. Purchase intentions are simultaneously influenced by brand trustand brand advocates.
Pengaruh Motivasi, Beban Kerja Dan Penilaian Kerja Yang Memiliki Dampak Pada Kepuasan Kerja Guru SMP Negeri 3 Lasem
Authors: Hasanah Uswatun , Lukiarti Ming Ming
Published: December 2023

The purpose of this research activity is to prove and explain the impact of motivation variables,workload and work assessment on teacher job satisfaction at SMP Negeri 3 Lasem. The researchpopulation consisted of 34 teachers from the school, and saturation techniques were used to takesamples from the entire population. Data was collected through a questionnaire survey, and data wasanalyzed through multiple regression. This research obtained results where individual workloadvariables had no significant effect on job satisfaction, while individual motivation and workassessment variables had a significant effect on teacher satisfaction. The dependent variable of jobsatisfaction of 93.6% can be explained by three independent variables: motivation, workload, andwork assessment. Other variables outside the research accounted for 6.4% of the dependent variablejob satisfaction.
Despacio y a tientas: la arqueología uruguaya y las comunidades indígenas
Authors: Sotelo Rico Moira , Figueiro Gonzalo
Published: December 2023

Analizamos la relación entre la arqueología y los colectivos indígenas en Uruguay a partir de conversatorios desarrollados en dos etapas. La primera, incluyó a la comunidad arqueológica; la segunda implicó la apertura al intercambio con indígenas. Como resultado de estas instancias observamos que las inquietudes de la arqueología uruguaya en cuanto a los indígenas refieren a: la continuidad histórica de las comunidades actuales, los interlocutores con quienes dialogar y la disyuntiva respecto a asumir posturas concretas en cuanto a reivindicaciones políticas. Las inquietudes indígenas incluyen: la construcción conjunta de conocimiento, el consentimiento con respecto a las excavaciones y la declaratoria de Salsipuedes como sitio de memoria, que constituye a la vez un hito y un foco de tensión. Aunque tardío en el contexto regional, el diálogo entre indígenas y academia en Uruguay se encuentra aún en una etapa germinal, continúa siendo necesario y tiene perspectivas fructíferas.