bluuebunny/crossref_metadata_2025 huggingface dataset:
Análise comparativa entre a realização do exame dos pés de pessoas com diabetes e a utilização do aplicativo CARPeDIA para prevenção da úlcera do pé diabético
Authors: Toledo Érica Mascarenhas , Ferreira Ana Cláudia Barbosa Honório
Published: January 2024

Introdução: As complicações do Diabetes Mellitus podem ser diversas e podem se desenvolver rapidamente, sendo destaque nesta pesquisa a úlcera do pé diabético. Objetivo: Realizar uma análise comparativa entre a utilização do aplicativo CARPeDIA e o resultado do exame dos pés de pessoas com diabetes. Método: estudo descritivo, com abordagem quantitativa, de análise comparativa, realizado uma investigação comparativa entre a utilização do aplicativo CARPeDIA e a inspeção dos pés de pessoas com diabetes. Os dados foram coletados no Centro Universitário de Lavras, nos dias de atendimento do projeto de extensão Pé em dia = Pé com vida (CAAE 60224222.2.0000.5116). Resultados: os resultados puderam extrair dados apresentados pelo uso do aplicativo e os resultados obtidos durante a consulta de enfermagem. A pesquisa contou com uma amostra de 20 participantes, foi possível observar um público feminino, perfil de pessoas idosas e com diabetes do tipo 2. Destaque-se que, o uso do app e do exame dos pés de pacientes são complementares. O app auxilia o paciente na identificação do risco para úlcera e promove autocuidado, e o exame complementa a análise mediante a identificação de alterações já instaladas. Considerações finais: A análise comparativa entre a realização do exame e o uso do aplicativo é fundamental na prevenção de úlceras de pacientes com diabetes.
Technology Acceptance Model (TAM) applied to a Disciplinary Social Network for online psychology students
Authors: Meza Cano José Manuel , González Santiago Edith , Morales Ruiz Mario Ernesto
Published: January 2024

Social networks have been present in people's daily lives to share information and communicate with family and friends. In the educational field, they have come up with commonly used social networks such as Facebook and Twitter-X, however, these networks have been accused of accessing user data without their consent for marketing purposes. In this scenario, there are open-source social networks that can be used in the educational field, thus creating Disciplinary Social Networks (Disciplinary SN). Our research objective is to evaluate the Attitude, Intention to Use, Perceived Usefulness, Ease of Use, Trust and Perceived Risk of a Disciplinary Social Network. For this, we used a modified Technology Acceptance Model (TAM) instrument. The sample consisted of 211 university students from an online psychology degree and users of a Disciplinary Social Network based on the Mastodon social network. The results obtained show considerably high means in all scales of the modified TAM instrument, except for perceived risk, which obtained a low mean. It is concluded that the Disciplinary Social Network was perceived as a safe and reliable environment, with a low perception of risk, in contrast to the findings of other authors who evaluated the same elements in commonly used social networks such as Facebook.
Goodbye to Russia, Russia and Russia! : Finland’s New NATO Chapter Within the Framework of Shelter Theory
Authors: KULALI MARTIN Yeliz
Published: January 2024

One significant impact on the international system of the ongoing Russia-Ukraine War has been Finland’s NATO membership. This article suggests that Baldur Thorhallsson’s shelter theory is the most suitable explanation for Finland’s decision. According to the theory, an alliance relationship with NATO will remedy the lack of hard security shelter of a state categorized as a small state in the literature. Many experts believe that this is a pragmatic choice by Finland against the Russian threat. On the other hand, Finland has a long history with Russia and is known for its neutral and peaceful policies, trying to establish a balance between East and West. For the above-mentioned reasons, membership in NATO is a much more difficult decision than it seems on the surface. In this framework, this article will first explain the place of Thorhallsson’s theory in International Relations. Then, Finland’s general foreign policy choices will be examined in light of current shelter relationships. Finally, in presenting the country’s history with NATO, it will focus on the potential consequences of the membership.
Epilepsy in patients with glioblastoma: Mechanisms of occurrence and problems of treatment (part 2)
Authors: Vasilenko A. V. , Ulitin A. Yu. , Lebedev I. A. , Ablaev N. R. , Dikonenko M. V. , Mansurov A. S. , Shaikhov M. M.
Published: January 2024

Epilepsy caused by glioblastoma requires careful study of the combination of factors causing it, with an integrated approach to prevention and complete relief when seizures occur against the background of adequate and modern treatment regimens. Control of seizures often requires the administration of antiepileptic drugs concomitantly with other treatments, including surgery, radiation, and chemotherapy. Pharmacological interactions between antiepileptic drugs and antineoplastic agents may alter the activity of both treatments, reducing their effectiveness and increasing the likelihood of side effects associated with both therapies. The presented literature review summarizes novel pathophysiological pathways associated with glioblastoma and involved in epileptogenesis, and also describes the interaction between antiepileptic drugs and oncological treatment. The article focuses on the impact of treatment on survival and presents evidence of the effectiveness of antiepileptic treatment, including the potential usefulness of new third-generation antiepileptic drugs. The second part of the article discusses in detail aspects of both preventive and symptomatic treatment of patients with epilepsy associated with glioblastomas.
Effectiveness of gabapentin in treatment of pain in patients with alcoholic polyneuropathy
Authors: Gusev V. V. , Zaitseva O. V. , Lvova O. A.
Published: January 2024

Alcoholic polyneuropathy is a pressing problem in modern society. This neurological disease is characterized by impaired functions of many peripheral nerves due to the toxic effects of alcohol and its metabolites on nerve fibers. A study was conducted to assess the effectiveness of the use of Gabapentin-SZ (North Star Co., Russia) in alcohol polyneuropathy, involving 47 adult patients (31 men and 16 women). The study found significant efficacy of Gabapentin-SZ in treating pain in patients with alcohol polyneuropathy. Significant improvement was noted after 14 days of therapy.
Graphene as basis of biological sensors for determining markers of neurodegenerative dementia
Authors: Vorobev S. V. , Ternovykh I. K. , Plekhanov A. Yu. , Lebedev A. A. , Smirnov A. N. , Usikov A. S. , Lebedev S. P. , Puzyk M. V. , Roenkov A. D.
Published: January 2024

Objective. To develop technique immobilizing antibodies graphene surface of proteins that play a significant role in pathogenesis Alzheimer's disease.Materials and methods. Graphene films were obtained sublimation surface of SiC substrates. Presence graphene monolayer was confirmed spectroscopy spectra. Graphene surface quality was evaluated cyclic voltammetry. Functionalization by amino groups was carried out method based on sorption pyrene derivatives from a solution and phenylnitrogroups electrochemical method. Graphene was kept in solutions monoclonal antibodies to human beta-amyloid peptide 1–42. Preparations were also kept in solution secondary antibodies labeled with FITZ. Results were evaluated fluorescence microscopy. Additionally, samples were kept in solution antibody with peroxidase label, which was detected chemiluminescence.Results. For attachment specific antibodies surface of graphene, quality its surface is great importance. Optimal working concentration of antibodies of human beta-amyloid 1–42 in solution for subsequent manufacture biological sensors is 15 micrograms per 1 ml. Covalent crosslinking antibodies with glutaraldehyde with amino groups on graphene gives a slight gain in the level fluorescence compared with noncovalent sorption on graphene with nitro groups. Functionalization phenylnitrogroups is optimal for further work related to the identification specific antigens.Conclusions. The technique of immobilization on the graphene surface of specific antibodies to beta-amyloid in concentrations detected by fluorescence microscopy and chemiluminescence is investigated. Amount antibodies sufficient to create a biosensor is immobilized on graphene. It was found that functionalization of phenylnitrogroups allows creating optimal conditions for the attachment of antibodies to the graphene surface, as well as washing resulting antibody-antigenic complexes for further reuse of graphene biosensors.
Relationship between biomarkers of autophagy and inflammation in acute period of ischemic stroke
Authors: Emanuel V. S. , Lugovaya A. V. , Ivanov A. M. , Sukhina I. А. , Sukhina I. А. , Kirilkin G. E. , Loseva A. P. , Melikhova D. V. , Nosulya P. N. , Zabirov S. Sh. , Emanuel Yu V. , Barantsevich E. R.
Published: January 2024

Postischemic neuroinflammation is a critical pathophysiological process within the entire pattern of cerebral ischemia, spanning early injury and tissue repair. According to recent experimental data, autophagy is involved in the regulation of neuroinflammation, influencing the outcome of the acute period of ischemic stroke (IS).Objective. To evaluate the relationship between autophagy biomarkers and inflammation indicators in the dynamics of the acute period of atherothrombotic IS.Materials and methods. 112 patients in the acute period of newly developed atherothrombotic IS and 56 donors (control group) were examined. Patients underwent dynamic clinical and neurological examination on the 1st, 7th and 14th days from the onset of the disease (magnetic resonance imaging, testing using the NIHSS scale, modified Rankin scale). At the same time intervals, blood was drawn for testing. The number of active autophagosomes in peripheral blood was assessed by flow cytometry using a specific Cyto-ID dye. The serum concentrations of proinflammatory cytokines IL‑1β, IL‑8, IL‑18 (interleukins‑1β, -8, -18), TNFα (tumor necrosis factor-α), autophagy biomarkers Beclin‑1, LC 3 and p62 were determined by enzyme-linked immunosorbent assay analysis. C-reactive protein was assessed by a highly sensitive immunoturbidimetric method.Results. A statistically significant increase in the studied parameters was revealed compared to the control group. The maximum increase in inflammation biomarkers was observed on the 1st day, and the maximum increase in key indicators of autophagy (LC 3, Beclin‑1, Cyto-ID) – on the 7th day after the development of ischemia. A direct relationship was established between the level of autophagy and the concentration of inflammatory biomarkers (CRP, IL‑1β, IL‑18, TNF-α) on the 1st and 7th days of acute IS.Conclusions. The identified correlations indicate the participation of activated autophagy in the regulation of post-ischemic neuroinflammation and its involvement in ischemic brain damage in the early stages of the acute period of IS (days 1–7). The results obtained confirm the literature data on the influence of autophagy on the outcome of the acute period of the disease.
New possibilities of overcoming pharmacoresistance in epilepsy
Authors: Sorokovikova T. V. , Menshikova T. V. , Morozov A. M. , Kryukova A. N. , Naumova S. A.
Published: January 2024

Despite the presence of antiepileptic drugs with different mechanisms of action and application points, almost a third of patients still remain resistant to drug therapy. In such patients, the risk of physical and mental injuries, depression, premature death increases, and the quality and standard of living decreases.Objective. To study the mechanisms of formation of pharmacoresistance in epilepsy and to evaluate possible ways to overcome it based on the analysis of current scientific publications containing information on this topic.Results. The proposed pathophysiological mechanisms of the formation of drug resistance reflect the target hypothesis, the carrier hypothesis, pharmacokinetic theory and neural network theory. However, they are based on preclinical studies and do not have a comprehensive explanation for the appearance of this phenomenon. Surgical treatment remains the most studied and most commonly used approach. Both the usual resection of the epileptogenic part of the brain and new less crippling interventions are used: laser ablation and stereotactic radiosurgery. As an alternative, polytherapy schemes, invasive and non-invasive neurostimulation techniques, and diet therapy can be considered.Conclusions. Insensitivity to antiepileptic drugs remains a major problem in epileptology, and to overcome it, new methods are being sought and developed to influence the presumed pathogenetic targets of pharmacoresistant epileptogenesis. Vagus, deep, transcranial neurostimulation, stereotactic surgery, and laser ablation should be considered as new safe and potentially effective techniques.
Cognitive function status in polymorbid patients with arterial hypertension, atrial fibrillation and chronic kidney disease
Authors: Shatalova N. A. , Dzamikhov K. K. , Kochetkov A. I. , Batyukina S. V. , Ebzeyeva E. Y. , Ostroumova O. D.
Published: January 2024

Background. Cognitive impairment is a public health problem. Polymorbid patients with arterial hypertension (AH), atrial fibrillation (AF), and chronic kidney disease (CKD) are at high risk of developing cognitive impairment, resulting in impaired quality of life, difficulty in medication adherence, and increased risk of mortality.Objective. To evaluate the cognitive status of polymorbid patients aged 60 years and older with essential AH and FP depending on the presence and stage of CKD.Materials and methods. 165 patients aged 60 years and older with essential AH and AF (80 [48.5 %] men, 85 [51.5 %] women, mean age was 82 [76; 85] years) were included and divided into three groups depending on the presence and stage of CKD: 55 (33.3 %) patients with AH and AF without CKD, 55 (33.3 %) patients with AH, AF, and CKD C 3a, and 55 (33.3 %) patients with AH, AF, and CKD C 3b. All patients included in the present study were examined for cognitive functions using a series of neuropsychological tests.Results. In the study of cognitive functions (Mini-mental State Examination, MMSE, Alzheimer Disease Assessment Scale-Cognitive (ADAS-cog), Digit Symbol Substitution Test (DSST), literature Association Test), it was found that the severity of cognitive impairment increased with increasing stage of CKD.Conclusions. The obtained results of the study indicate an unfavorable effect of CKD on cognitive functions in elderly and elderly patients with AH and FP. Thus, there is a need for regular monitoring and examination of patients with concomitant CKD for cognitive impairment.
Impact of anti-CGRP monoclonal antibodies on central sensitization level in migraine patients
Authors: Berdnikova A. V. , Kadymova N. B. , Latysheva N. V. , Filatova E. G.
Published: January 2024

Background. Central sensitization (CS) is the mechanism underlying chronic migraine and other conditions combined into a group of central sensitivity syndromes. The most reliable method for assessing the severity of CS is Central Sensitization Inventory (CSI).Aim. The aim of our study is the evaluation of anti-CGRP monoclonal antibodies (erenumab, fremanezumab) effect on the central sensitization level in migraine patients.Material and methods. We recruited 90 patients over 18 years old diagnosed with episodic migraine (EM) and chronic migraine (CM) according to the International Classification of Headache Disorders, 3rd edition. All patients were from November 2020 to March 2022. Demographic data, history of migraine and previous migraine treatment were collected for each patient. All patients filled out CSI. Dynamics was followed up monthly with headache diaries.Results. After six months of treatment the level of CS in the CM group significantly decreased from the initial level of 41 (32.0, 50.5) to 36 (25.0, 39.0), which corresponds to the absence of clinically significant CS, p = 0.02*. The analysis of points of the CSI after 3 months of treatment shows a significant decrease in the prevalence of pain syndromes, cognitive impairment, asthenic disorders, hypersensitivity and affective disorders.Conclusions. The use of erenumab and fremanezumab is advisable in patients with migraine and comorbid conditions based on the CS mechanism.
Gender Differences in Labor Force Participation Rates in Spain and Italy under the Great Recession.
Authors: Rodríguez-Modroño Paula , Addabbo Tindara , Gálvez Muñoz Lina
Published: January 2024

This article analyzes gender differences in the decision to participate in the labor market under the economic crisis that derive from differences in women’s position in the job structure, the family and the welfare economy. In order to test the behavior of male and female labor supply in Spain and Italy, we estimate labor supply models for women and men living in couples. The results show a strong countercyclical added-worker effect for women, in contrast with a procyclical discouraged-worker effect for men. Though the added-worker effect prevails for women in Spain, in Italy the discouraged worker effect dominates.
The Correlation Between Amylopectin Chain-Length and Glycemic Index Value of Carbohydrate Foods: A Review
Authors: Afandi Frendy
Published: January 2024

The relationship between starch characteristics and the glycemic index (GI) of carbohydrate foods is interesting to study. One of the advances in analytical techniques in characterizing starch is measuring the degree of polymerization of amylopectin chains. Amylopectin is the main component of carbohydrate starch granules. There have been many publications regarding long chain fractions of amylopectin. The aim of this research is to analyze the relationship between amylopectin chain length and the glycemic index of carbohydrate foods. The method used was to tabulate various studies related to data on amylopectin chain length and the glycemic index of carbohydrate foods. Then a regression analysis was carried out between the degree of polymerization of the amylopectin chain and the Pearson correlation between the degree of polymerization and the glycemic index value. The research results showed that there was a strong correlation between the amylopectin chain length with degree of polymerization (DP) 6-12, 13-24, and 25-36 with the glycemic index value of carbohydrate foods. The degree of polymerization of the amylopectin chain is the number of glucose units that make up the chain. The resulting regression equation is y=0.3123x-0.6256 with a value of r2=0.991. The chain length of amylopectin influences starch properties, including the glycemic index. Starches with shorter amylopectin chains have a lower glycemic index, while starches with longer amylopectin chains have a higher glycemic index. The results of this research provide a new perspective for the field of food chemistry that the characteristics of amylopectin influence the glycemic index value of carbohydrate foods.
The Effect of Tenors, Installments, Loans on Arrears, and Moderating Variables
Authors: Ardiansyah
Published: January 2024

The research objective is to determine the effect of tenors, installments, and loans on arrears and moderating variables. This type of quantitative research. Secondary data type. The research population for customer loan data for 2017-2022 and customer loans maturing in 2022-2027 are 527 customers as a sample. The analytical method uses path analysis with the help of SmartPLS 3. The results of the study: (1) Tenors have a negative and significant effect on Arrears; (2) Tenors have a negative and significant effect on Installment; (3) Loans have a positive and significant effect on Tenors; (4) Loans have a positive and significant effect on Arrears; (5) Loan has a positive and significant effect on Installment; (6) Installment has a negative and significant effect on Arrears; (7) Loans are not significant to Arrears moderated by Installment; and (8) Tenors have a negative and significant effect on Arrears moderated by Installment. The research findings provide empirical evidence that the determinants of customer arrears that can have an impact on arrears are tenors, loans, and installments. The implication of the research results is the discovery of factors that need to be considered by the company in providing loans to customers by carefully considering the alignment between loans to tenors, then tenors to installments so that the determination is not burdensome to customers so that arrears are smaller and can increase company profitability. Recommendations for further research: (1) Conduct data analysis on consumptive and productive loans; (2) Develop variables: Remaining loan principal, Arrears of fines, and Interest arrears.
The Influence of Environmental, Social, Governance (ESG) and Green Innovation on Company Business Performance
Authors: Ramadhan Ahmad , Widiastuty Erna
Published: January 2024

The research aims to provide empirical evidence on the relationship of ESG and green innovation to company's business performance. The independent sample of this research is ESG was measuring ESG score. Dependent variables green innovation were measures using innovation of green product and innovation of green process. Sampling used in this research is purposive sampling technique. The sample of this research consisted of 66 manufacturing companies from 2016 to 2021. The data collected was analyzed using panel data regression analysis. This result shows that ESG positively influence business performance proxied by Tobin's Q and ROA unsupported. Green Innovation, which is proxied by green product innovation on the company's business performance, shows mixed results. Where green product innovation positively influence the company's business performance proxied by ROA. Conversely, green product innovation does not influence company's business performance proxied by Tobin's Q. Meanwhile, Green Innovation proxied by Green Process innovation effect on the company's business performance is not supported. Thus, it can be seen that ESG has not become a concern for investors in Indonesia, as evidenced by the limited number of public companies that disclose ESG scores. Green Innovation which is proxied by green product innovation and green process innovation shows mixed results which shows that customers are also considering purchasing products from companies whose innovations produce environmentally friendly products
Perkembangan Penelitian Indikator Kota Berkelanjutan Menggunakan Bibliometric Analysis dan Systematic Literature Review
Authors: Widyawati Laili Fuji , Istiqomah Asti , Yolamalinda Yolamalinda
Published: January 2024

Tiga pilar keberlanjutan yakni ekonomi, ekologi dan sosial telah menjadi hal yang mendasar dalam pembangunan termasuk pembangunan kota yang berkelanjutan. Kota yang berkelanjutan adalah kota yang aman secara lingkungan, inklusif secara sosial, dan layak secara ekonomi, yang memungkinkan semua warganya, baik saat ini maupun di masa depan, untuk memenuhi kebutuhan pribadi dan meningkatkan kualitas hidup mereka tanpa mengorbankan alam dan kehidupan manusia. Evaluasi yang efektif terhadap keberlanjutan kota menjadi hal yang penting untuk pembangunan berkelanjutan. Dalam mengevaluasi, diperlukan pengukuran indikator-indikator keberlanjutan. Dengan itu, tujuan dari penelitian ini adalah untuk mengidentifikasi perkembangan dan produktivitas publikasi penelitian kota berkelanjutan dengan menggunakan bibliometric analysis dan untuk mengidentifikasi indikator dalam mengevaluasi keberlanjutan sebuah kota dengan menggunakan Systematic Literature Review (SLR). Data diperoleh melalui metode pencarian dari database jurnal terkemuka Scopus dan pencarian manual. Materi yang didapatkan lalu disaring dalam tiga langkah, yaitu identifikasi, penyaringan, dan kelayakan. Berdasarkan analisis bibliometrik, teridentifikasi bahwa wordcloud dari kata kunci penelitian yang populer yaitu sustainability dan sustainable development sedangkan riset dengan kata kunci indikator masih terbatas. Hasil SLR, terdapat total 36 materi dan dokumen yang ditemukan dan dirangkum untuk disoroti. Hasil penelitian menunjukkan bahwa indikator dalam kota berkelanjutan yaitu 225 indikator yang terdiri dari dimensi social budaya (65 indikator), lingkungan (75 indikator), ekonomi (51 indikator), ICT/transverse (12 indikator) dan urban (22 indikator).
Evaluasi Tata Letak Bangunan terhadap Garis Sempadan Jalan di Kecamatan Tomoni, Kabupaten Luwu Timur
Authors: Hidayatullah Moesayyid , Listyarini Sri
Published: January 2024

Kawasan Perkotaan Mangkutana, Tomoni, dan Tomoni Timur yang kemudian disingkat menjadi “Matoto” merupakan kawasan perkotaan yang ada di Kabupaten Luwu Timur. Pusat kegiatan ekonomi di kawasan ini terletak di Kecamatan Tomoni yang kemudian mengalami perkembangan wilayah. Perkembangan wilayah menimbulkan banyaknya pertumbuhan bangunan yang tidak sesuai dengan Peraturan Daerah (Perda) Kabupaten Luwu Timur Nomor 5 Tahun 2012 sebagaimana telah diubah dengan Perda Nomor 8 Tahun 2018 tentang Garis Sempadan, maka dari itu penulis tertarik untuk melakukan evaluasi tata letak bangunan di kecamatan tersebut yang melanggar dan tidak sesuai dengan peraturan daerah yang ada. Kemudian penulis memspesifikkan daerah penelitian pada Ruas Jalan Trans Sulawesi. Penelitian ini bertujuan untuk melihat besaran ketidaksesuaian luasan kaveling bangunan terhadap peraturan daerah. Adapun analisis yang digunakan adalah analisis overlay dengan perintah union. Dari hasil analisis diperoleh bahwa luas wilayah kaveling bangunan yang masuk ke dalam daerah Rumaja seluas 46,76%; Rumija seluas 16,70%; dan Ruwasja sejumlah 36,54%.
Comparing novel sperm extenders for the internally-fertilizing tiger salamander (Ambystoma tigrinum)
Authors: Chen Devin M. , Kouba Carrie K. , Songsasen Nucharin , Roth Terri L. , Allen Peter J. , Kouba Andrew J.
Published: January 2024

Due to the concentrated nature and small volume of spermic milt that is typically produced from internally-fertilizing salamanders, an extender is needed to analyze the sperm for quality and quantity metrics. Techniques for diluting salamander sperm for analysis have thus far utilized low osmolality media, which are likely physiologically distinct from the salamander female reproductive tract. Application of mammalian sperm extenders could maintain salamander sperm motility and morphology in storage longer due to the similar nature of internal fertilization in both taxa. Several sperm extenders were tested including: Multipurpose Handling Medium, Sperm Washing Medium, Modified Ham’s F-10 Basal Medium (HAM’s), Refrigeration Medium, and 10% Holtfreter’s solution as a control. The experimental treatments were divided into two groups: diluted (90 mOsm, the approximate osmolality of salamander sperm) and undiluted (280-320 mOsm). Milt samples were collected from male tiger salamanders (N=11) and diluted 1:50 with each of the treatments and measured for sperm progressive motility, total motility, and normal morphology every 10 minutes for one hour. When comparing the diluted versus undiluted treatments of the same extender, there was no difference (p>0.05) for any of the response variables. In addition, we found that 10% Holtfreter’s solution is best for maintaining progressive motility, while diluted HAM’s is best for retaining total motility and normal morphology over time. Overall, we found that osmolality is not a key driver influencing tiger salamander sperm motility, but rather other factors such as ionic composition or pH could be affecting sperm form and function.
Surprising magic of CD24 beyond cancer
Authors: Wang He , Shi Peng , Shi Xinyu , Lv Yaqing , Xie Hongwei , Zhao Hai
Published: January 2024

CD24 has emerged as a molecule of significant interest beyond the oncological arena. Recent studies have unveiled its surprising and diverse roles in various biological processes and diseases. This review encapsulates the expanding spectrum of CD24 functions, delving into its involvement in immune regulation, cancer immune microenvironment, and its potential as a therapeutic target in autoimmune diseases and beyond. The ‘magic’ of CD24, once solely attributed to cancer, now inspires a new paradigm in understanding its multifunctionality in human health and disease, offering exciting prospects for medical advancements.
Where the leatherbacks roam: movement behavior analyses reveal novel foraging locations along the Northwest Atlantic shelf
Authors: Rider Mitchell J. , Avens Larisa , Haas Heather L. , Hatch Joshua M. , Patel Samir H. , Sasso Christopher R.
Published: January 2024

Leatherback sea turtles (Dermochelys coriacea) migrate along the east coast of the United States, traversing the South and Mid-Atlantic Bights (SAB and MAB) while traveling to and from well-known northern foraging areas off Southern New England (SNE) and Nova Scotia. However, there is limited information on leatherback movement behavior in these regions. To identify leatherback movement patterns, we fit hidden Markov models (HMMs) to satellite transmitter data from 52 leatherbacks tagged between 2017 and 2022 off the coasts of Massachusetts and North Carolina to estimate locations of area restricted searching (ARS) and transient behaviors. Depth-temperature profiles were then paired to locations associated with ARS behavior to understand the vertical use of the water column. We observed leatherbacks displaying ARS behavior in SNE as expected, but also in the MAB and SAB. The HMM results indicated that leatherbacks were primarily foraging in SNE between Nantucket and Long Island Sound and depth-temperature plots from ARS behavior on Nantucket Shoals implied turtles foraging throughout the entire water column. In the MAB, ARS behavior was concentrated between Cape Hatteras, North Carolina, and the mouth of Delaware Bay during the summer. Turtles were closely associated with a well-defined thermocline, but still appeared to dive to deeper cooler waters, which may be a sign of thermoregulatory behavior. There was evidence of foraging in the SAB along the coast as well as along the continental shelf edge. The ARS behavior we documented within the MAB and SAB is the first published empirical evidence that both areas may be important foraging grounds. Our results lay a path for future research to understand how leatherbacks use these areas and the potential anthropogenic threats encountered while moving through these regions.
Mast cell in infantile hemangioma
Authors: Xia Meng , Liu Wenying , Hou Fang
Published: January 2024

Infantile hemangioma (IH) is the most common benign vascular tumor characterized by three phases — proliferation, early involution and late involution. Mast cells (MCs) play an important role in allergic reactions and numerous diseases, including tumors. While the mechanisms underlying MCs migration, activation and function in the life cycle of IH remain unclear, previous studies suggested that MCs circulate through the vasculature and migrate into IH, and subsequently mature and get activated. Estradiol (E2) emerges as a potential attractant for MC migration into IH and their subsequent activation. In various stages of IH, activated MCs secrete both proangiogenic and anti-angiogenic modulators, absorbed by various cells adjacent to them. Imbalances in these modulators may contribute to IH proliferation and involution.
Ferroptosis in head and neck squamous cell carcinoma: from pathogenesis to treatment
Authors: Yang Jing , Gu Zhaowei
Published: January 2024

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignant tumor worldwide, with high morbidity and mortality. Surgery and postoperative chemoradiotherapy have largely reduced the recurrence and fatality rates for most HNSCCs. Nonetheless, these therapeutic approaches result in poor prognoses owing to severe adverse reactions and the development of drug resistance. Ferroptosis is a kind of programmed cell death which is non-apoptotic. Ferroptosis of tumor cells can inhibit tumor development. Ferroptosis involves various biomolecules and signaling pathways, whose expressions can be adjusted to modulate the sensitivity of cells to ferroptosis. As a tool in the fight against cancer, the activation of ferroptosis is a treatment that has received much attention in recent years. Therefore, understanding the molecular mechanism of ferroptosis in HNSCC is an essential strategy with therapeutic potential. The most important thing to treat HNSCC is to choose the appropriate treatment method. In this review, we discuss the molecular and defense mechanisms of ferroptosis, analyze the role and mechanism of ferroptosis in the inhibition and immunity against HNSCC, and explore the therapeutic strategy for inducing ferroptosis in HNSCC including drug therapy, radiation therapy, immunotherapy, nanotherapy and comprehensive treatment. We find ferroptosis provides a new target for HNSCC treatment.
Celecoxib ameliorates diabetic sarcopenia by inhibiting inflammation, stress response, mitochondrial dysfunction, and subsequent activation of the protein degradation systems
Authors: Deng Chunyan , Lu Chunfeng , Wang Kexin , Chang Mengyuan , Shen Yuntian , Yang Xiaoming , Sun Hualin , Yao Xinlei , Qiu Chunjian , Xu Feng
Published: January 2024

Aim: Diabetic sarcopenia leads to disability and seriously affects the quality of life. Currently, there are no effective therapeutic strategies for diabetic sarcopenia. Our previous studies have shown that inflammation plays a critical role in skeletal muscle atrophy. Interestingly, the connection between chronic inflammation and diabetic complications has been revealed. However, the effects of non-steroidal anti-inflammatory drug celecoxib on diabetic sarcopenia remains unclear.

Materials and Methods: The streptozotocin (streptozotocin)-induced diabetic sarcopenia model was established. Rotarod test and grip strength test were used to assess skeletal muscle function. Hematoxylin and eosin and immunofluorescence staining were performed to evaluate inflammatory infiltration and the morphology of motor endplates in skeletal muscles. Succinate dehydrogenase (SDH) staining was used to determine the number of succinate dehydrogenase-positive muscle fibers. Dihydroethidium staining was performed to assess the levels of reactive oxygen species (ROS). Western blot was used to measure the levels of proteins involved in inflammation, oxidative stress, endoplasmic reticulum stress, ubiquitination, and autophagic-lysosomal pathway. Transmission electron microscopy was used to evaluate mitophagy.

Results: Celecoxib significantly ameliorated skeletal muscle atrophy, improving skeletal muscle function and preserving motor endplates in diabetic mice. Celecoxib also decreased infiltration of inflammatory cell, reduced the levels of IL-6 and TNF-α, and suppressed the activation of NF-κB, Stat3, and NLRP3 inflammasome pathways in diabetic skeletal muscles. Celecoxib decreased reactive oxygen species levels, downregulated the levels of Nox2 and Nox4, upregulated the levels of GPX1 and Nrf2, and further suppressed endoplasmic reticulum stress by inhibiting the activation of the Perk-EIF-2α-ATF4-Chop in diabetic skeletal muscles. Celecoxib also inhibited the levels of Foxo3a, Fbx32 and MuRF1 in the ubiquitin-proteasome system, as well as the levels of BNIP3, Beclin1, ATG7, and LC3Ⅱ in the autophagic-lysosomal system, and celecoxib protected mitochondria and promoted mitochondrial biogenesis by elevating the levels of SIRT1 and PGC1-α, increased the number of SDH-positive fibers in diabetic skeletal muscles.

Conclusion: Celecoxib improved diabetic sarcopenia by inhibiting inflammation, oxidative stress, endoplasmic reticulum stress, and protecting mitochondria, and subsequently suppressing proteolytic systems. Our study provides evidences for the molecular mechanism and treatment of diabetic sarcopenia, and broaden the way for the new use of celecoxib in diabetic sarcopenia.
Interaction between the microbiota and the skin barrier in aging skin: a comprehensive review
Authors: Woo Yu Ri , Kim Hei Sung
Published: January 2024

The interplay between the microbes and the skin barrier holds pivotal significance in skin health and aging. The skin and gut, both of which are critical immune and neuroendocrine system, harbor microbes that are kept in balance. Microbial shifts are seen with aging and may accelerate age-related skin changes. This comprehensive review investigates the intricate connection between microbe dynamics, skin barrier, and the aging process. The gut microbe plays essential roles in the human body, safeguarding the host, modulating metabolism, and shaping immunity. Aging can perturb the gut microbiome which in turn accentuates inflammaging by further promoting senescent cell accumulation and compromising the host’s immune response. Skin microbiota diligently upholds the epidermal barrier, adeptly fending off pathogens. The aging skin encompasses alterations in the stratum corneum structure and lipid content, which negatively impact the skin’s barrier function with decreased moisture retention and increased vulnerability to infection. Efficacious restoration of the skin barrier and dysbiosis with strategic integration of acidic cleansers, emollients with optimal lipid composition, antioxidants, and judicious photoprotection may be a proactive approach to aging. Furthermore, modulation of the gut-skin axis through probiotics, prebiotics, and postbiotics emerges as a promising avenue to enhance skin health as studies have substantiated their efficacy in enhancing hydration, reducing wrinkles, and fortifying barrier integrity. In summary, the intricate interplay between microbes and skin barrier function is intrinsically woven into the tapestry of aging. Sound understanding of these interactions, coupled with strategic interventions aimed at recalibrating the microbiota and barrier equilibrium, holds the potential to ameliorate skin aging. Further in-depth studies are necessary to better understand skin-aging and develop targeted strategies for successful aging.
Nurturing positive mental health and wellbeing in educational settings – the PRICES model
Authors: Frazier Tyralynn , Doyle Fosco Sebrina L.
Published: January 2024

This article presents a comprehensive framework for the implementation of social and emotional learning (SEL) programs as a means of health promotion in educational settings, to positively impact student, school, and adult mental health and wellbeing across education. It emphasizes the profound impact of education on life trajectories and success definitions. Drawing inspiration from the Greek myth of Icarus and Maya Angelou’s poem “Still I Rise,” it explores contrasting notions of success and their consequences. Schools play a pivotal role in shaping students’ wellbeing across multiple dimensions and developmental stages. Because of this, holistic mental health and wellbeing promotion that takes a whole-school approach is critical. The paper introduces the PRICES framework (Preparation and Access, Restoration, Integration, Connection and Community, Educator Support, Strengths-Based Cultivation and Student Voice) as a comprehensive method for implementing SEL programs in educational systems. Each component of the PRICES framework is discussed in detail, emphasizing its role in fostering positive health promotion within schools. Examples of implementation plans that operationalize this model through a co-development process focusing on the Social, Emotional, and Ethical (SEE) Learning program are also presented. The PRICES model encourages a shift towards a more holistic approach to education, nurturing social and emotional development alongside academic achievement. By prioritizing wellbeing, fostering a sense of community, and integrating evidence based SEL interventions, schools can positively impact the mental health and overall flourishing of students and educators, contributing to thriving communities.
Microbiological substantiation of the effectiveness of quercitin and its combination with ethylmethylhydroxypyridine succinate in the complex treatment of odontogenic phlegmon and maxillofacial abscesses
Authors: Lokes Kateryna , Kiptilyi Anatolii , Skikevych Margaryta , Steblovskyi Dmytro , Lychman Vitaliy , Bilokon Serhii , Avetikov David
Published: January 2024

Odontogenic infections can become life-threatening. The aim of the study was to determine the effectiveness of quercitin and its combination with ethylmethylhydroxypyridine succinate in the complex treatment of odontogenic infections by assessing the microbial population of the infection site.

Materials and methods

The cross-sectional study included 75 patients. Purulent exudate was collected from the infection site. The number of colony-forming units was counted using the standard plate method.

Results

The microbiological examination of purulent exudate obtained from the patients revealed the general prevalence of Gram-positive cocci. On the seventh day of treatment, the total number of microorganisms in the purulent exudate of patients in group I, whose treatment included a combination of the standard protocol with quercitin, significantly decreased compared to the first day of the same group. The results of treatment of patients in group II, which included the standard protocol in combination with quercitin and 2-ethyl-6-methyl-3-hydroxypyridine succinate, demonstrate a significant decrease in the total number of bacteria in the infection focus on the fifth day of treatment compared to this indicator of the group at the beginning of the study.

Conclusions

When quercitin was used as part of complex treatment, the total treatment period was reduced by 1.4 days. However, the combined use of quercitin and ethylmethylhydroxypyridine succinate against the background of standard treatment of patients with odontogenic infection contributed to a reduction in hospital stay by 2 days.
Gestión motivacional y logro de competencias en estudiantes de una institución educativa, Chimbote-Perú
Authors: Nomberto Luperdib Ana Zoila , Flores Ccanto Florencio , Gonzales Salvador Gamaniel Domingo , Boza Muñoz Joan Carlos , Ibarguen Cueva Francis Esmeralda
Published: January 2024

La gestión motivacional en Perú enfrenta retos significativos que requieren una atención cuidadosa y medidas específicas para promover un entorno educativo más estimulante y efectivo. Por ello, el estudio tuvo como objetivo, relacionar la gestión motivacional y el logro de las competencias de Ciencia y Tecnología en estudiantes de una institución educativa de Chimbote. El tipo de estudio descriptivo, con diseño no experimental, transversal, de análisis correlacional. El muestro fue probabilístico estratificado constituido por 97 estudiantes de cuarto año. Se usó como técnica la encuesta y la observación, los instrumentos fueron dos cuestionarios para evaluar la “Gestión motivacional” y el “Logro de competencias en Ciencia y tecnología”. Como resultados se obtuvo que la gestión motivacional es percibida como buena por el 53% de estudiantes y a la vez el logro de las competencias se halló en inicio en el 52% de estudiantes estableciendo que existe una relación directa (x2= 6.471) y significativa (p-valor 0,000 < 0,05) entre la gestión motivacional y el logro de las competencias del área de Ciencia y Tecnología. Se concluye destacando las implicaciones para la práctica educativa, como la necesidad de desarrollar estrategias pedagógicas que impulsen y refuercen la motivación de los alumnos como un factor crucial para su éxito académico.
La defensa de los derechos fundamentales : tres diferentes cauces jurisdiccionales en la Constitución española
Authors: Martín-Retortillo Baquer Lorenzo
Published: January 2024

A recent constitution, like the Spanish one of 1978, emphasises on three occasions, judicial control of administrative activity Firstly, dealing with basic rights, it tackles the principle of the concept of the "fair trial" or the "right to effective judicial supervision". Secondly, dealing with the Administration, it establishes the general criterion of judicial control. And thirdly, establishes the rule of "effective recourse" whenever there is a violation of basic rights. The influence of Italian constitutionalism is put into question insofar as the first two points are concerned. In order to keep a tight reign on the government when Franco's dictatorial regime ended, emphasis was placed on giving a clear role to the Judiciary. The result was an outpouring of judicial cases, leading to a collapse of the system. This would become a common phenomenon, intensely felt throughout Europe, requiring urgent solutions whilst avoiding the need for judicial conflict as much as possible. The same philosophy applies in the specific instance of "undue delay" in the exercise of justice now on the agenda, which is severely affecting the functioning of the European Court of Human Rights and is contributing to a loss of prestige, which should be avoided at all costs.
Hubungan antara pengetahuan dan fasilitas kebersihan dengan manajemen kebersihan menstruasi pada santriwati di pondok pesantren al-mutawally kabupaten kuningan
Authors: Indrayani Indrayani , Salsabila Fiarus Filhaq , Ropii Ahmad
Published: January 2024

Latar Belakang: Berdasarkan hasil studi pendahuluan dari 20 orang santriwati terdapat 13 santriwati masih kurang memahami pengetahuan mengenai manajemen kebersihan menstruasi. Menstruasi merupakan masa perdarahan yang terjadi pada perempuan secara rutin setiap bulan selama masa suburnya kecuali apabila terjadi kehamilan. Proses alamiah ini terjadi rata-rata sekitar 2 sampai 8 hari. Penelitian ini bertujuan untuk mengetahui faktor yang berhubungan dengan manajemen kebersihan menstruasi.Metode: Jenis penelitian kuantitatif analitik dengan desain cross sectional. Populasi penelitian seluruh santriwati Ponpes Al-Mutally. Pengambilan sampel menggunakan total sampling sebanyak 120 santriwati. Instrumen dalam penelitian ini yaitu menggunakan kuesioner. Analisis data yang digunakan yaitu uji rank spearman.Hasil: Hasil penelitian univariat menunjukkan bahwa sebagian kecil berpengetahuan cukup sebesar 47 responden (39,2%), fasilitas kebersihan buruk sebesar 75 responden (62,5%), manajemen kebersihan buruk sebesar 52 responden (43,3%). Hasil bivariat p value pengetahuan sebesar (p=0,000), fasilitas kebersihan sebesar (p=0,037.Kesimpulan: Terdapat hubungan antara pengetahuan danfasilitas kebersihan dengan manajemen kebersihan menstruasi di Pondok Pesantren Al- Mutawally Kabupaten Kuningan.