bluuebunny/crossref_metadata_2025 huggingface dataset:
Abnormalities in the functional activity of neural networks in a human iPSC model of Dravet syndrome
Authors: Mzezewa Ropafadzo , Hyvärinen Tanja , Vinogradov Andrey , Pesu Emma , Isosaari Lotta , Kulta Oskari , Vuolanto Valtteri , Kapucu Fikret Emre , Schuster Jens , Dahl Niklas , Narkilahti Susanna
Published: February 2025

Dravet syndrome (DS) is a severe pediatric epilepsy with a limited response to current antiseizure medications. Majority of DS cases are caused by a de novo mutation in the SCN1A gene, encoding the alpha subunit of the voltage-gated sodium channel. While early in vivo studies have shown that DS pathology results from the disinhibition of GABAergic inhibitory neurons, recent studies report alterations in sodium currents in both excitatory and inhibitory neurons. Investigating the excitatory-inhibitory interplay is essential for elucidating the functional alterations caused by SCN1A mutations. Here, the aim was to study how different SCN1A gene pathogenic variants affect the functional phenotype of DS human induced pluripotent stem cell-derived neuronal networks in enriched GABAergic cultures and heterogeneous glutamatergic and GABAergic cultures, using microelectrode arrays (MEAs). We report functional differences in patient-derived GABAergic cultures. In heterogeneous cultures, DS patient-derived neurons displayed altered activity with prominent network bursts and overall, the altered functional activity correlated with the clinical severity of the disease. Principal component analysis revealed distinct clustering between the DS patient and control heterogeneous cultures. Thus, pathogenic SCN1A variants alter the neuronal network functionality suggesting that heterogeneous cultures are competent physiological models for characterizing disease phenotype alterations in DS using MEAs.
Epidemiological Characteristics and Temporal Trends of Malignant Melanoma from 1990 to 2021, with Projections until 2044
Authors: Yao Ling , Li Yonghai , Li Huashang , Qian Guixiang , Zhang Zhuhui , Quan Longfang , Liu Qiuling , Dai Jie , Lei Xuedi , Jia Xiaoqiang
Published: February 2025

OBJECTIVE
Malignant melanoma, one of the most metastatic human cancers, is on the rise globally. However, its low prevalence leads to insufficient concern and its latest worldwide burden remains unclear. This study aims to update its epidemiological features to prompt timely and impactful interventions.
METHODS
Weanalysed malignant melanoma incidence, disability-adjusted life years (DALYs), and mortality trends from 1990 to 2021 across 204 countries using GBD 2021 data. We also projected incidence and mortality rates for the next two decades.
RESULTS
Globally, the age-standardized incidence rate (ASIR) of malignant melanoma in 2021 was 3.6 per 100,000 people with the estimated annual percentage change (EAPC) of the ASIR from 1990–2021 was 0.6%. The age-standardized DALYs rate (ASDR) of malignant melanoma in 2021 was 19.6 per 100,000 people with the ASDR EAPC from 1990 to 2021 was -0.7%. The age-standardized mortality rate（ASMR）of malignant melanoma in 2021 was 0.7 per 100,000 people with the ASMR EAPC from 1990 to 2021 was -0.4%. Australia remained the region with the highest ASIR, ASDR, and ASMR in 2021. Older adult males had higher rates than females for all three measures.
The incidence of MM is predicted to remain stable over the next twenty years while the mortality rate will significantly decline.
CONCLUSION
The global ASIR of malignant melanoma increased from 1990 to 2021, while the ASDR and ASMR decreased during the same period. High-SDI countries and older adult males require enhanced measures for the prevention and control of malignant melanoma.
Synergy of a Complimentary Ionic Biogel Network for Through-Hair Neurohaptics
Authors: Cheng Huanyu , Dutta Ankan , Biswas Md Abu Sayeed , Meng Long , Gerhard Ethan , Calva Arantza Moreno , Zhang Wanqing , Abdullah Abu Musa , Joharji Lana , Che Yuju , Yang Jian , Hu Xiaogang
Published: February 2025

Understanding the neural mechanisms underlying haptic sensations is crucial for advancing neuroprosthetics. However, achieving on-site amplification non-invasively through-hair neural recordings remains a significant challenge as it requires thermoreversible, bioadhesive, and semiconducting characteristics in the same material. Typical polymer composite compromises on complementary properties. To address this, we present a membraneless organelles - inspired ionic biogel that leverages liquid–liquid phase separation. This enables a unique synergy of complementary properties, including rapid thermoreversible transitions, p-type semiconductivity, thermoelectricity, enhanced electrochemical stability, self-healing, and bioadhesive capabilities. These characteristics enable to analyze the frequency dependence of event-related desynchronization during electrical stimulation over days mimicking the frequency response of mechanoreceptors sensation. This thermoresponsive, semiconducting ionic biogel also enables a phase-reversible, self-balancing, tip-shaped vertical organic electrochemical transistor with a high transconductance of 44 mS at 40°C. The ionic biogel demonstrates synergistic complementary properties to understand through-hair neurohaptics.
Strain-Driven Oxygen Vacancy Ordering in LaNiO3 Thin Films: Impact of Ruddlesden-Popper Faults
Authors: Banerjee Pritam , Orgiani Pasquale , Meingast Arno , Lazar Sorin , Sushko Peter , Spurgeon Steven , Ciancio Regina
Published: February 2025

The study of rare-earth nickelates, such as LaNiO3 (LNO), is significant due to their complex electronic properties. Ordered oxygen vacancies (OOV) in LaNiO3 − x decrease conductivity, converting it from metallic to insulating state as 'x' approaches 0.5, and semiconducting behavior near x = 0.75. These OOV also influence magnetic properties, causing LNO to exhibit anti-ferromagnetic and ferromagnetic behavior instead of its usual paramagnetic state. Interfacial strain in thin-film heterostructures is utilized to regulate the creation of oxygen vacancies and Ruddlesden-Popper (RP) faults, leading to notable impacts on materials' structural and electronic phases. The effect of strain on the formation of RP faults and the critical thickness of a fault-free layer in LNO has been studied, but atomic-scale insights into the relationship between strain, OOV, and RP faults are still limited. In this paper, we systematically investigated the effect of strain and RP faults on the formation of OOV in LNO thin films grown on SrTiO3 (STO) substrates. Using high-angle annular dark-field scanning transmission electron microscopy (HAADF-STEM) and integrated differential phase contrast (iDPC) STEM imaging, we conducted atomic-scale structural and compositional analyses of OOV. Geometric phase analysis (GPA) was employed to measure the strain in fault-free and RP fault regions, while density functional theory (DFT) calculations explored different OOV arrangements in the LNO phase. Simulated iDPC-STEM imaging of energy-stabilized structures was performed to correlate with experimental results. Our findings reveal superstructure modulation in the chemical composition and atomic-scale lattice structure in LNO, primarily due to the formation of the OOV in Ni-O layer of LaNiO2.5 phase. The out-of-plane compressive strain of about 2% stabilizes this phase, reducing the strain, diminishing OOV, and transforming them into LNO.
Mannanase from Lactic Acid Bacteria Pediococcus acidilactici: Production optimization, Purification and Application in juice clarification
Authors: Shi Jingjun , Chen Xi , Yang Ruoxi , Zhao Dan
Published: February 2025

Pediococcus acidilactici, a generally regarded as safe (GRAS) lactic acid bacteria species, is a desirable microbial mannanase source due to high bio-safety. P. acidilactici HDM2 isolated from dragon fruit culture was identified according to morphological, physiological and biochemical characters as well as preserved nucleic acid (16S rDNA and rpoA) sequencing. A two-step response surface methodology (RSM) experiment subsequently screened out and then predicted the optimal levels of two factors which significantly affected P. acidilactici HDM2’s mannanase production. The maximal enzyme activity reached 97.9 U/mL under the condition of glucose 17.5 g/L and initial pH 4.6. RSM optimization resulted in a 39.3% increase of mannanase yield which was verified by six repeated trials and consequent t-test (P < 0.05). The enhancement of mannanse production was also proved by congo-red dyeing on KGM (konjac glucomannan)-MRS (de Man, Rogosa and Sharpe) agar. Diameter of clearance zone enlarged from 2.7 cm to 4.5 cm through RSM. The purified P. acidilactici HDM2 mannanase with molecular weight of 30 KDa was then applied in fruit juice clarification process. The enzyme exhibited significantly higher clarifying efficiency than commercial mannanase in both yield and clarity for six out of eight fruits, i.e. orange, peach, grape, pear, kiwi and grapefruit. These results promised the application of P. acidilactici HDM2’s mannanase in various especially food-level field.
Using Bayesian Methods to Identify Predictors of Freshmen Attrition
Authors: Lauría Eitel J.M.
Published: February 2025

This study employs Bayesian hierarchical generalized linear models to investigate predictors of freshmen student attrition using Marist University student data from nine academic years (n=10921) and across its six schools. The proposed framework builds hierarchical binary logistic regression models to estimate the posterior probability distributions of models' parameters and derived metrics. The paper shows how to formulate hierarchical generalized (Bernoulli) linear models and implement them in a probabilistic programming platform to compute the models' parameters posterior distributions using Markov chain Monte Carlo (MCMC) techniques. Tests were carried out to study model fitness, parameter convergence and the significance of the regression parameter estimates.The results identify university academic performance, financial need, gender, and work-study program participation as predictors having a significant effect on the log-odds of freshmen attrition. Additionally, the study reveals fluctuations across time and schools. Such fluctuations would have been overlooked if flat, pooled regression models were used instead of the multilevel approach applied in this work. Variation of freshmen retention across schools highlights the need for retention-focused initiatives that include targeted strategies, as some schools seem to be more vulnerable to higher attrition rates than others. The research provides valuable findings to stakeholders, administrators, and decision-makers that can be applied and utilized by other institutions, as well as a detailed guideline on how to analyze educational data using Bayesian methods.
Investigation of Reservoir Properties, Sedimentary Environment, and Reservoir Modeling of Sarvak Reservoir Formation in a Southwestern Iranian Oil Field
Authors: Asghari Mohammad Reza , Jahani Davood , Arian Mehran , Sheikhzakariaee Seyed Jamal , Aleali Seyed Mohsen
Published: February 2025

The Late Albian-Early Cenomanian Sarvak Formation is a significant oil reservoir in the Zagros region of southwestern Iran. This study examines the reservoir characteristics, sedimentary environment, and modeling of the Sarvak Formation using seismic data from an Iranian field. A total of 11 facies were identified based on allocomes and orthocomes, indicating deposition in a homoclinal ramp environment across four sub-environments: outer ramp, middle ramp, and inner ramp. The reservoir quality of the Sarvak Formation is primarily influenced by sedimentary facies and diagenesis processes, which include bioturbation, micritization, chemical and mechanical compression, cementation, neomorphism, dissolution, porosity, dolomitization, and fracturing across marine, meteoric, and burial environments. Additionally, four discontinuities—Lower Cenomanian, Middle Cenomanian, Cenomanian-Turonian boundary, and Middle Turonian discontinuity—were identified based on ancient soil, shearing, meteoric porosity, and karstization. This study recognizes four sedimentary sequences: the Albian Barian-Lower Cenomanian, Middle Cenomanian, Barian Cenomanian, and Lower to Middle Turonian. All sequence boundaries are classified as SB1, except for the lower boundary of the first sequence, which is SB2. The TST sections of the first and second sequences show low reservoir quality, while the third and fourth TST sequences exhibit good to excellent reservoir quality due to supporting grain rudist facies. The third and fourth HST sequences provide the best reservoir quality in this formation. Under the discontinuities, meteorically influenced diagenesis processes have significantly increased mold porosity and extensive dissolution features.
Evaluation of water delivery performance of the Bontanga irrigation scheme in the Northern Region of Ghana
Authors: Sibale Davis , Kranjac-Berisavljevic Gordana , Abdul-Ganiyu Shaibu
Published: February 2025

This study was undertaken at the Bontanga irrigation scheme in the Northern Region of Ghana to identify shortfalls within the irrigation water delivery system, propose solutions for the system's performance improvement, and project the impact of water delivery improvement on water demand using the Water Evaluation and Planning (WEAP) model. The study employed the following performance indicators; irrigation efficiencies, relative irrigation supply (RIS), irrigation ratio (IR), and sustainability of irrigated area index. The results showed average conveyance, distribution, application, and overall irrigation efficiencies of 85.6, 63, 58, and 31.30%, respectively. The low overall irrigation efficiency was attributed to underutilisation of flow measuring structures, poor canal maintenance, excessive canal tailwater losses, and poor water management at the field level. The RIS ranged from 1.02 to 1.09. The IR and sustainability of the irrigated area index were 62 and 100%, respectively. By improving the overall irrigation efficiency from 31.30 to 60%, the WEAP model projected that total seasonal water demand could drop by 16.50%, contributing to an average seasonal water saving of 3,894,597.86 m3 during the simulation period (2024–2030). Study findings will help irrigation managers and farmers to improve water delivery performance and sustainably meet the competing water demands.
KARA ZESŁANIA NA PRZYMUSOWE PRACE W KOPALNI (‘DAMNATIO AD METALLA’) W PRAWIE RZYMSKIM
Authors: Kubiak Przemysław
Published: February 2025

Kara zesłania na przymusową pracę do kopalni (damnatio ad metalla) stanowiła jedną z podstawowych sankcji karnych wymierzanych osobom z niższych warstw społecznych oraz niewolnikom przez cały okres trwania cesarstwa rzymskiego. Analiza źródeł prawnych ukazuje, że była ona wymierzana w przypadku przestępstw średnio ciężkich na równi z zesłaniem do szkół gladiatorskich, z którym to dzieliła wiele cech wspólnych, w tym przede wszystkim popadnięcie w niewolę skazanego. Była to kara najbliższa karze śmierci ze względu na warunki panujące w kopalniach, gdzie osadzeni cierpieli najróżniejsze dolegliwości i dodatkowe tortury podczas wykonywania nieludzkiej pracy. Istniały również łagodniejsze stopnie tej kary, które nie powodowały zmiany statusu na niewolny, w szczególności gdy orzekano je jedynie na pewien okres. O jej powszechnym stosowaniu decydowały nie tylko czynniki ekonomiczne czy społeczne, lecz także ideologiczne, związane z założeniami prowadzonej polityki karnej oraz pojmowaniem sprawiedliwości przez ówczesnych Rzymian.
ZARYS DZIAŁALNOŚCI SĄDU SPECJALNEGO W WARSZAWIE (SONDERGERICHT WARSCHAU) W LATACH 1939-1945
Authors: Graczyk Konrad
Published: February 2025

W artykule zarysowano podstawowe aspekty działalności niemieckiego Sądu Specjalnego w Warszawie (1939-1945). Przedstawiono okoliczności jego utworzenia, właściwości miejscowej i rzeczowej. Omówiono ustrój, obsadę stanowiska przewodniczącego (kierownika), dane personalne sędziów, prokuratorów i urzędników. Przedstawiono również, na podstawie zgromadzonego w różnych archiwach materiału źródłowego, statystykę orzecznictwa. W związku z informacjami dotyczącymi zawartości zniszczonych akt, ilustrujących gigantyczną liczbę wyroków śmierci wydanych przeciwko Żydom, przedstawiono wstępną ocenę działalności tego sądu oraz postulat monograficznego opracowania tej problematyki, ze szczególnym uwzględnieniem jakościowych badań zachowanego orzecznictwa.
ZASADY LOKALIZOWANIA NOŚNIKÓW REKLAMOWYCH W ŚWIETLE WYMOGÓW OCHRONY KRAJOBRAZU
Authors: Zwolak Sławomir
Published: February 2025

Artykuł dotyczy problematyki sytuowania reklam i urządzeń reklamowych w polskim prawie. Celem obowiązujących regulacji prawnych jest bezpieczeństwo i ochrona przestrzeni publicznej. Realizacja tej ochrony wyraża się przede wszystkim w prawodawstwie określającym zasady ochrony krajobrazu. Wyrazem efektywnej polityki w tym zakresie jest określenie obowiązków dotyczących przewidzianej reglamentacji robót budowlanych polegających na instalowaniu tablic i urządzeń reklamowych.
Morfologia dos anexos embrionários e fetais de emas Rhea americana Linnaeus, 1758
Authors:   , Gadelha Ana Indira Bezerra Barros
Published: February 2025

A ema é uma ratita silvestre com importância científica e grande potencial zootécnico,
especialmente se considerado o atual estado de desenvolvimento do setor avícola brasileiro
onde pesquisas voltadas ao incremento da produtividade da agropecuária brasileira assumem
grande relevância. Estudos com anexos fetais e desenvolvimento embrionário são
importantes, pois podem evidenciar informações imprescindíveis ao manejo reprodutivo e
nutricional dos animais. O presente estudo foi desenvolvido levando em consideração a
ausência de informações sobre a morfologia dos anexos fetais em emas, objetivando-se
estabelecer um modelo padrão para os anexos nesta espécie. Ovos de emas foram incubados de
zero a 36 dias (3, 6, 9, 12, 15, 21, 24, 27, 30, 33, 36) e foram realizadas as caracterizações
macroscópicas e microscópicas dos seus anexos embrionários. Ao término do experimento
constatou-se que o padrão de desenvolvimento observado em emas é similar ao de outras
aves. Histologicamente observou- se que todos os anexos embrionários possuem camadas de
folhetos germinativos: ectoderme, mesoderme e endoderme em sua constituição.
Seleção para resistência e resiliência a endoparasitoses como estratégia para a conservação de ovinos nativos
Authors:   , Monteiro Hudson de Queiroz
Published: February 2025

A Morada Nova é uma raça nativa do nordeste brasileiro. Devido a introdução de
raças exóticas na produção de ovinos houve erosão genética da raça, principalmente na
variedade branca. A conservação dos recursos genéticos é essencial para a manutenção da
agrobiodiversidade. Infecções parasitárias causadas por endoparasitas são a principal
preocupação e obstáculo enfrentado pelos criadores de ovelhas, devido a essa problemática o
objetivo desse estudo é fornecer ferramentas para a conservação dos ovinos da raça Morada
Nova, variedade Branca, através de marcadores fenotípicos para seleção de animais
resistentes ou resilientes às endoparasitoses nos rebanhos comerciais. A pesquisa foi realizada
em 7 rebanhos, avaliando-se um total de 90 fêmeas adultas, sendo todas matrizes da raça
Morada Nova, variedade branca, nos estados do Rio Grande do Norte e Ceará. Foram feitas
duas visitas para coleta de dados em cada propriedade. As datas das visitas foram divididas de
acordo com o período do ano em que há o maior e o menor índice pluviométrico, dividindo-os
em período seco e período chuvoso. As coletas do período seco foram realizadas nos meses de
setembro e outubro e as coletas do período chuvoso em abril e maio. O levantamento dos
dados de todos os animais foi feito através da coleta de fezes, sangue, aferição da temperatura,
auscultação dos batimentos cardíacos e frequência respiratória, avaliação do escore
Famacha©, medição de peso e avaliação do escore de condição corporal. O gênero
Haemonchus foi prevalente em todas as propriedades. Durante todo o experimento as médias
de contagem de ovos fecais se mantiveram abaixo de 400 e as médias de hematócrito acima
de 30%. O escore Famacha© apresentou maior frequência nos valores 3 e 4, enquanto os
valores de escore de condição corporal obtiveram maiores frequências entre 2 e 2,75. A
associação dos marcadores fenotípicos contagem de ovos fecais, hematócrito e escore
Famacha© mostrou que a Morada Nova variedade branca apresenta boa resistência e
resiliência aos endoparasitas da região. Essa informação pode ajudar no desenvolvimento de
programas de seleção da raça, concedendo visibilidade a variedade branca, modificando a
visão dos produtores quanto as suas qualidades e, consequentemente, aumentando sua
população que estava em risco de extinção.
Estudo da influência de fatores externos no desempenho de sistemas fotovoltaicos conectados à rede de BT utilizando o software ATP
Authors:   , Nascimento Vitória Caroline Carvalho do
Published: February 2025

O desempenho dos sistemas fotovoltaicos é fundamentalmente impactado por fatores
externos, dentre eles variáveis climáticas como a irradiância solar e a temperatura do local de
instalação, e o sombreamento dos módulos do arranjo. De modo que, diante de condições
desfavoráveis, pode-se reduzir significativamente a eficiência do sistema. Nesse contexto, este
trabalho tem como objetivo implementar um modelo computacional, através da utilização de
técnicas de modelagem, do sistema de controle TACS (Transient Analysis of Control
Systems) e da linguagem MODELS no software ATP (Alternative Transient Program) e na
sua interface ATPDraw, para a realização de simulações e do estudo do funcionamento e do
desempenho de sistemas fotovoltaicos conectados à rede elétrica de BT (Baixa Tensão), sob a
influência dos fatores externos irradiância solar, temperatura e sombreamento. A metodologia
utilizada neste trabalho contém cinco etapas: levantamento de dados, modelagem matemática
e computacional, simulações do sistema modelado sob a influência de fatores externos,
comparação dos resultados com os dados de referência e validação do modelo. Foram
plotados os gráficos de corrente, tensão e potência dos componentes: módulos fotovoltaicos
operando isoladamente; módulos fotovoltaicos, conversor boost, MPPT (Maximum Power
Point Tracking) e PWM (Pulse Width Modulation) para o chaveamento do conversor boost;
PLL (Phase Locked Loop) e a rede elétrica de BT; inversor, PLL, controle de corrente, PWM
para o chaveamento do inversor, indutor de acoplamento e a rede elétrica de BT; e do sistema
fotovoltaico conectado à rede elétrica de BT. Foi possível analisar o funcionamento do
sistema modelado, com a verificação da influência dos fatores externos estudados, e verificar
a confiabilidade e a validade da modelagem do sistema fotovoltaico conectado à rede elétrica
de BT, diante da sua eficiência de, aproximadamente, 96%
Antena mimo na frequência sub 6-GHZ aplicado à tecnologia 5G
Authors:   , Assis Katiane Estevam Gurgel de
Published: February 2025

Os sistemas de comunicação modernos baseados em antenas de Múltiplas Entradas e Múltiplas Saídas (MIMO - Multiple Input-Multiple Output), representam um importante avanço para os sistemas de telecomunicação. Além de proporcionar alta capacidade de rede com maior quantidade de dados entregues a vários usuários de forma simultânea, ainda consegue uma maior cobertura de sinal. Tal tecnologia é uma das principais aliadas para os dispositivos móveis da quinta geração, onde a faixa de 3,5GHz será exclusiva para o 5G no Brasil. Diante deste contexto, aqui foram produzidas antenas MIMO 2x2 para atuar na faixa de 3,5GHz, utilizando o substrato dielétrico de FR4 de 1,57 mm, com geometrias retangular, circular e dipolo, para analisar as mudanças nos parâmetros de desempenho, em decorrência do tipo de geometria. As antenas projetadas foram simuladas através do software comercial Ansoft Designer-HFSS, e têm dimensões globais de 100,5x100,5 mm, 100,5x100,5 mm e 50,5x50,5 mm, para as geometrias retangular, circular e dipolo, respectivamente. Os resultados apresentaram leves deslocamentos da frequência de ressonância entre os valores simulados e medidos, com destaque para a geometria dipolo que ressoou em 3,57 GHz. Para o coeficiente de correlação de envoltória (ECC), as três geometrias mostram valores abaixo de 0,50, já em relação ao ganho de diversidade, as geometrias, retangular e circular apresentaram-se melhor que a dipolo, com valores superiores a 8 dB para toda a faixa de operação
Nucleic Acid-based Therapy in Effective Management of Rheumatoid Arthritis
Authors: Singh Yashpreet , Singh Aniket , Geoffrey Priscar , Chaitanya MVNL , Kaur Jaskiran
Published: February 2025

Rheumatoid Arthritis (RA) is a chronic autoimmune disease that prominently affects the joints of
the body, including one or more types, such as wrists, knees, fingers, and toes. This condition is characterized
by specific auto-immune responses, i.e., inflammation, swelling, stiffness, and pain in the body's joints. This
results in partial or complete immobility. Several treatment options are available in the pharmaceutical market,
commonly immunosuppressants, anti-inflammatory drugs, corticosteroids, anti-antibody drugs, etc. However,
such drug treatments provide only symptomatic relief and lack long-term therapeutic efficacy. Thus, there is a
need to develop an alternative treatment option that potentially can cure this disease. Recently, researchers
have shifted their focus to targeting the root cause involved in the pathogenesis of RA by designing nucleic-acid-
based molecules. With this objective, we have provided this review in which we have explored the nucleic
acid-based techniques used to treat RA. Various molecular and genetic methods, including antisense oligonucleotides,
small interfering RNA (siRNA), CRISPR-Cas9 gene editing, RNA-based vaccines, microRNA (miRNA)
therapeutics, and epigenetic modifications are used to target the mechanisms underlying RA pathogenesis.
Through the extensive evaluation of clinical and preclinical studies, we reported nucleic acid-based therapy's
clinical efficacy, safety, and therapeutic benefits. In addition, this study states the associated pharmacokinetic
challenges followed by approaches to overcome them. Nucleic acid-based therapies are susceptible to
degradation by nucleases in the body and are not efficiently absorbed due to their considerable molecular
weight. Specialized carriers like nanoparticles are employed for their effective delivery. Nucleic acid-based
therapies hold immense potential for achieving more effective, less toxic, and patient-centric management of
RA, offering hope for improved outcomes and an enhanced quality of life for individuals living with this challenging
autoimmune condition.
Exploring self-victimhood’s place in moral personality and unethical organizational behavior
Authors: Wilmore Thomas , Kriletic Ana , Svyantek Daniel , Donnelly Lilah
Published: February 2025

Recent research has shown that a tendency for interpersonal victimhood (TIV) predicts maladaptive thinking and antagonistic behavior. However, understanding TIV’s place in the nomological network of personality variables used to predict moral behavior in organizations.  This paper attempted to bridge this gap by examining TIV’s associations with morally relevant personality traits and TIV’s prediction of unethical organizational behavior in two studies. For the studies, we relied on two samples of U.S. adults recruited via an online crowdsourcing platform (NTotal = 1,080) using survey methods. Study 1 (N = 485) showed that TIV had a sizeable loading onto an overarching Dark Factor of Personality (D), which contained TIV, the Dark Tetrad, and moral disengagement. Study 2 (N = 405-595) showed that TIV predicted counterproductive work behavior (CWB) and unethical pro-organizational behavior (UPB), even after controlling for morally relevant HEXACO traits and demographic variables. Supplemental analyses indicated that TIV’s rumination facet primarily drives its relationship with CWB, while its lack of empathy facet primarily drives its relationship with UPB. TIV tended to have small to moderate positive correlations with dark traits (e.g., the Dark Triad, moral disengagement) (r = 0.30-0.50) and small negative correlations with light traits (e.g., the Light Triad, Honesty-humility, moral identity-internalization). This research provides evidence supporting TIV’s place in the nomological network of moral personality and its influence on destructive organizational behavior.
PERCEPTION OF PUBLIC INSECURITY AND HOUSING PRICES IN MEXICO
Authors: Cuevas Ahumada Víctor Manuel
Published: February 2025

This paper evaluates the impact of the perception of public insecurity on housing prices in Mexico. To that end, two dynamic panel data models involving 27 Mexican cities are assembled. The first model corresponds to the pre-pandemic period, while the second to the pandemic period. The specification of the model is based on a supply- and demand-side approach, whereas its estimation relies on the Arellano-Bond technique to address endogeneity problems. The evidence is consistent in showing that: 1) Housing prices fall as the perception of public insecurity rises, and 2) higher construction costs and income levels raise home prices. Moreover, the provision of public infrastructure and the real mortgage interest rate generate demand- and supply-side effects, so the net effect of these two variables on housing prices is negative before the pandemic and positive during the pandemic. Finally, housing prices involve a strong inertial component.
Las anomias en el régimen contractual mexicano respecto de las tecnologías de la información y la comunicación
Authors: Simental Franco Víctor Amaury , Ortega Laurel Carlos
Published: February 2025

Es llevado a cabo un estudio pormenorizado del régimen contractual mexicano en materia del consentimiento manifestado a través de las llamadas “TIC” (tecnologías de la información y comunicación), describiendo las deficiencias normativas, tanto por falta de norma, como por falta de supuestos qué regular.
Escepticismo jurídico y convenciones. Los límites del convencionalismo y el desafío de Dworkin
Authors: Arena Federico José
Published: February 2025

En este texto propondré una defensa del escepticismo jurídico frente a las críticas que le dirigiera Hart. Para ello, mostraré que una posición escéptica permite superar el desafío de Dworkin; mientras que eso no sucede con el convencionalismo, de base hartiana. Según Hart, el escepticismo es una mala teoría de los deberes jurídicos, ya que no encaja con los enunciados de deber pronunciados por los jueces. Sin embargo, Dworkin ha argumentado que la teoría de Hart tampoco tiene éxito en ese sentido. Como respuesta, se recurrió a la noción de convención: aquí analizaré el convencionalismo constitutivo de Marmor y el convencionalismo constructivo de Postema. Desde mi punto de vista, en el intento por responder a Dworkin, ambas propuestas terminan exagerando la dimensión cooperativa de la práctica jurídica. Aquí defenderé una salida diferente que consiste en reformular algunas tesis escépticas. Para ello, sostendré, en primer lugar, que los enunciados de deber de los jueces son una proyección de sus actitudes, tanto sobre la acción considerada obligatoria o prohibida como sobre el método interpretativo convencional que utilizan para fundamentar ese enunciado. Segundo, que esta perspectiva proyectivista puede explicar el discurso de los jueces en términos de valor de verdad y sus desacuerdos.
Estrategias para la implementación del reúso de aguas residuales tratadas con fines de uso y consumo humano​
Authors: Ramírez Zamora Rosa María , Martín Domínguez Alejandra , Herrera Ibarra Lilia Margarita , Navarro Suástegui Martha Patricia , González Espinoza Lucía
Published: February 2025

El reúso del agua residual tratada con fines de uso y consumo humano es una alternativa que se ha implementado en algunas regiones del mundo ante la escasez de agua potable, que se ha agudizado en la última década por diversos factores como son el crecimiento demográfico, la disminución, sobreexplotación y contaminación de los recursos hídricos, y la consecuencia de los efectos del cambio climático que cambia la duración e intensidad de sequías.
El agua residual tratada para remover los contaminantes que ponen en riesgo la salud humana, puede reutilizarse de manera directa en sistemas de distribución de agua potable o indirectamente descargándola en ríos o cuerpos naturales de fuentes de plantas potabilizadoras.
El reúso de aguas residuales tratadas con fines de uso y consumo humano presenta pros pero también enfrenta grandes retos. Algunos de las ventajas son: la disminución de la demanda de agua de primer uso, el ahorro de energía y recursos en la extracción y conducción, el aumento de la disponibilidad, y la promoción de la sostenibilidad ambiental.
Entre los principales desafíos se encuentran: la cada vez más elevada contaminación del agua por agentes químicos o biológicos difíciles de remover y que pueden dañar la salud humana; el alto costo de construir y mantener las plantas de tratamiento y potabilización; y la resistencia social y cultural a consumir agua reciclada.
Este trabajo presenta un análisis de información recopilada, para determinar los aspectos más importantes a considerar para la implementación del reúso de aguas residuales tratadas con fines de uso y consumo humano.
En su capitulado se presenta la situación actual en México en materia de agua potable y tratamiento de agua residual; políticas y marco legal alrededor del mundo respecto al reúso de agua residual tratada con fines de uso y consumo humano; la calidad del agua y los métodos de medición; tecnologías de tratamiento de agua residual y potabilización; las etapas clave, consideraciones técnicas y métodos de control para llevar a cabo un proyecto de reúso de agua residual tratada; y finalmente, los avances y casos de éxito en el mundo en proyectos de reúso con fines de potabilización. Finalmente en las conclusiones se hacen algunas puntualizaciones sobre los retos que tiene el país si realmente desea implementar el reúso de aguas residuales tratadas con fines de uso y consumo humano.
Volver a lo presencial: un panorama estudiantil sobre cambios educativos
Authors: Fernández-Poncela Ana-María
Published: February 2025

El texto presenta las opiniones y valoraciones sobre los tipos de educación: remota, mixta y presencial. Ante los cambios que han tenido lugar en los últimos años, se analiza la mirada de las y los estudiantes sobre el tema, sus preferencias y caracterización positiva y negativa. Esto se hace a través de una encuesta aplicada en la Universidad Autónoma Metropolitana unidad Xochimilco a inicios de 2023, cuando el alumnado había transitado por las tres modalidades. Los resultados muestran una preferencia por la modalidad presencial; sin embargo, la explicación, reflexión y expresión del sentir de los estudiantes permite comprender sus posiciones generales y, en particular, las percepciones favorables y desfavorables hacia cada modalidad.
Pensamento linguístico no Brasil Quinhentista através da carta “Ao Geral Lainez, de Piratininga, março de 1562, recebida em Lisboa a 20 de setembro do dito ano” de José de Anchieta
Authors: Macedo Anderson Lucas , Lourenço Teixeira Viviane
Published: February 2025

Este artigo tem como objetivo principal trazer uma proposta de leitura, ancorada nos pressupostos teórico-metodológicos Historiografia Linguística, da carta escrita pelo padre José de Anchieta intitulada Ao Geral Lainez, de Piratininga, março de 1562, recebida em Lisboa a 20 de setembro do dito ano. Através da análise da mensagem em questão também se deseja compreender e descortinar o pensamento linguístico presente no Brasil quinhentista. Para que os objetivos sejam alcançados, este texto aborda o tema do Humanismo, movimento histórico-intelectual da época citada, e traz ainda uma breve biografia do autor da carta com o intuito de oferecer aos leitores uma contextualização apropriada.
De fios, labirintos e mistérios: A casa eterna, de Hélia Correia
Authors: Soares Fonseca Carlos Henrique
Published: February 2025

O presente artigo pretende analisar a relação entre o discurso literário e o discurso histórico a partir de uma de suas mais aclamadas narrativas: A casa eterna (1991), privilegiando aquilo que se entende como um processo de subversão do modelo da narrativa policial, consolidada no século XIX por Edgar Allan Poe e, tradicionalmente, pouco difundida em Portugal. Subverter o modelo do romance policial acaba por evidenciar um traço constante na obra de Hélia Correia: o recorrente uso da intertextualidade na composição de narrativas que propõem uma releitura crítica e estética de discursos anteriormente produzidos, resultando em uma produção compromissada em manter o diálogo com a memória da tradição, sem esquecer de procurar para si a sua forma de narrar.
misterioso caso da pesquisa brasileira sobre Agatha Christie
Authors: Jabala Mamede Vogel Michely
Published: February 2025

As publicações científicas são o registro oficial da ciência. Para que uma área se estabeleça, deve contar ao menos com uma associação científica e, principalmente, periódicos científicos sobre ela, e esse é o caso dos estudos sobre literatura policial. Nesta seara, Agatha Christie é uma das autoras mais conhecidas e prolíficas, no entanto, os estudos científicos brasileiros sobre a autora e suas obras são ainda escassos. O objetivo deste trabalho é, portanto, mapear as publicações científicas produzidas no Brasil sobre Agatha Christie e conhecer as influências intelectuais que orientam tais pesquisas, a fim de criar indicadores bibliométricos. Trata-se de uma pesquisa exploratória, amparada pela Bibliometria e pela técnica de Análise de Citações. Os resultados demonstram que: as pesquisas científicas sobre Agatha Christie têm aumentado, há pesquisadores e instituições de todas as regiões do Brasil, especialmente do Sudeste e que além da Letras, diversas áreas do conhecimento se interessam pelo tema. Conclui-se que obra de Agatha Christie é uma fonte para diversos tipos e abordagens de estudos e que tais pesquisas devem ser incentivadas.
SCREAM QUEENS: TEEN SERIAL KILLERS, TWITTER DEATHS AND TAYLOR SWIFT'S SOUNDTRACK
Authors: Frazão Pedro
Published: February 2025

ABSTRACT: 
This paper discusses the relevance of serial killers and psychopaths in contemporary narratives, presenting some strategies that have been used to maintain popular interest in these stories. It will present a concise history of this genre and how Ryan Murphy’s TV series Scream Queens offered some guidelines for the regeneration of serial killer and psychopath stories, for instance rethinking the moral values that identify the final girls and their antagonists. This article also analyzes extracts from the TV series, discussing its reference to Psycho among many other slashers and American horror movies.
Pedagogia dos multiletramentos: prática em aula de inglês
Authors: Rocha Moraes Lídia
Published: February 2025

Considerando o ideal de uma pedagogia crítica, que possibilite ao aluno sua atuação cidadã efetiva no mundo, bem como a transformação do mesmo por meio de uma ação local/global, este artigo visa a discussão da Pedagogia dos Multiletramentos. Ela endossa esse ideal numa proposta de aprendizagem que explora a construção de significados através de diferentes sentidos e modos de compreensão do mundo, incluindo as mídias digitais em sua prática. O presente trabalho utiliza-se de seus conceitos para, então, propor um plano de aprendizagem para aulas de inglês em curso livre que vá ao encontro do ideal descrito acima. Ainda, discorre sobre esse planejamento em ação, junto aos alunos, e analisa seu desenvolvimento na prática em sala de aula, visando pontos a serem aprimorados e momentos de êxito.
Unification Of Agro-Industrial businesses In the Sugar-Energy Sector: A Study of The Value of the Company
Authors: Caraski Thiago Henrique , Lucente Adriano dos Reis , Barbieri Luciana Aparecida , Rodrigues Maria Carolina Martins
Published: February 2025

Objective: Carrying out a comparative study to assess impact on company value next to the unification of two agro-industrial plants in the sugar-energy sector.
Method: Study with an applied nature consisting of two stages with different approaches. The first was qualitative and provided subsidies for the second stage, which was quantitative with predominantly exploratory characteristics. The technical procedure used was the case study with the use of research protocols and data collection gathered from in-depth interviews, documentary consultations and field observations. For the analysis’ results, the Content Analysis technique was used, in addition to the calculation of the Discounted Cash Flow with risk analysis by the Monte Carlo Simulation.
Result: In summary, it can be said that it was possible to identify that the company opted for the correct decision by unifying its units.
Originality: The work draws a parallel between company mergers and the unification of the company under study. Subject not frequently addressed in the literature.
Theoretical/Methodological Contributions: The study provided a detailed structure with the steps to be followed with interview scripts, analysis of variables and calculations of Company Value and Risk Analysis for future unification movements of other companies, in this or another sector.
Social Contributions: The study can contribute to the perception of the top management of the company under study, converging on the result of unification.
Keywords: Risks; Sugar-energy sector; Valuation.
Gestão do Conhecimento e Inovação Aberta: Uma Relação Simbiótica
Authors: Macedo Valéria , Thurler Larriza , Dias Elaine , Sachs Lais
Published: February 2025

O objetivo deste trabalho é investigar a relação simbiótica entre a gestão do conhecimento e a inovação aberta em hubs de inovação no Brasil. A originalidade da pesquisa reside em seu enfoque empírico, analisando as práticas e ferramentas de gestão do conhecimento utilizadas nesses ambientes. Metodologicamente, foi conduzida uma pesquisa descritiva e exploratória, utilizando dados secundários obtidos de 10 hubs de inovação privados em operação no Brasil, identificados por meio de um ranking da Open Startups. Os resultados revelam a relevância do compartilhamento de conhecimento e a colaboração para alcançar melhores resultados em iniciativas de inovação aberta. As implicações práticas deste estudo sugerem que gestores de hubs de inovação devem investir em processos de gestão do conhecimento e desenvolver mecanismos de avaliação para medir o impacto dessas práticas.
Upaya Meningkatkan Hasil Belajar Siswa Melalui Metode Biosong Pada Materi Jaringan Tumbuhan Kelas XI IPA
Authors: Jannah Zahwa Nafidatul , Roviati Evi
Published: February 2025

There are many incidents where students' understanding of biology subject matter is very poor. Looking at the statement above, there are many learning methods that can be applied to improve students' learning outcomes in the classroom. One of them is the application of the biological song method, which can be abbreviated as biosong. The aim of this research is to find out whether the Biosong learning method can have an effect on improving student learning outcomes in plant tissue material. Data collection techniques are carried out through observation and interviews, as well as posttest learning outcomes tests and documentation techniques. Data analysis in this research is: descriptive analysis and hypothesis analysis. In the experimental class Kolmogorov Smirnov calculation p-value = 0.002 < 0.05 so the data is not normally distributed and Shapiro-Wilk p-value = 0.008 < 0.05 so the data is not normally distributed, and the hypothesis test data obtained Sig 0.000 so the hypothesis is accepted. There is a significant influence between the learning outcomes of students who use the biosong learning method and the learning outcomes of students who use the biosong method.
Abstrak. Banyak sekali kejadian dimana pemahaman siswa terhadap materi pelajaran biologi sangat kurang. Melihat pernyataan di atas banyak metode pembelajaran yang mampu diterapkan untuk meningkatkan kemampuan hasil belajar siswa di dalam kelas. Salah satunya adalah penerapan metode lagu biologi (Biology Song) yang dapat disingkat dengan nama biosong. Adapun tujuan dari penelitian ini yaitu untuk mengetahui apakah metode pembelajaran Biosong dapat berpengaruh dalam Meningkatkan Hasil Belajar Siswa Pada Materi Jaringan Tumbuhan. Teknik pengumpulan data yang dilakukan melalui observasi dan wawancara, dan juga tes hasil belajar pemberian posttest lalu teknik dokumentasi. Analisis data pada penelitian ini yaitu: analisis deskriptif dan analisis hipotesis. Pada kelas eksperimen perhitungan kolmogorov smirnov p-value = 0,002 < 0,05 sehingga data berdistribusi tidak normal dan shapiro-Wilk p-value = 0,008 < 0,05 sehingga data berdistribusi tidak normal, dan data uji hipotesis diperoleh Sig 0,000 maka hipotesis diterima. terdapat pengaruh yang signifikan antara hasil belajar siswa yang menggunakan metode pembelajaran biosong dengan hasil belajar siswa yang menggunakan metode biosong.
Keterampilan Kolaborasi, Kreativitas, dan Hasil Belajar Kognitif Mahasiswa melalui Pembelajaran berbasis Proyek: Studi Kasus pada Pembuatan Sediaan Mikroskopis
Authors: Ilma Silfia , Sam Nur Fitriana , Iring Iring
Published: February 2025

Collaboration skills, creativity and cognitive learning outcomes are the main things that are achieved in learning. Collaboration skills are the ability to work together productively with mutual respect and responsibility.. Creativity is also very much needed to survive in the era of globalization. Cognitive learning outcomes are a crucial basis for developing higher levels. This research aims to provide an overview of collaboration skills, student creativity, and cognitive learning outcomes in project learning. This research uses quantitative descriptive methods. The instruments used were collaboration skills observation sheets, creativity description tests, and cognitive learning outcomes description tests. Data were analyzed using mean values. The research results show that the highest aspect of student collaboration skills is the aspect of productive work and responsibility in the very good category. Meanwhile, the lowest is in the compromise aspect. Student creativity is highest in the aspects of curiosity, fluency in thinking, elaboration in the very good category. Meanwhile, the lowest was in the divergent thinking aspect. The highest cognitive learning outcomes are in the application domain, while the lowest are in the evaluating aspect. Therefore, it can be recommended that project-based learning can empower collaboration skills, creativity, and improve cognitive learning outcomes.
Abstrak. Keterampilan kolaborasi, kreativitas, dan hasil belajar kognitif merupakan hal utama yang menjadi capaian dalam pembelajaran. Keterampilan kolaborasi akan membantu mahasiswa bekerja lebih produktif dalam menyelesaikan suatu permasalahan. Kreativitas juga sangat dibutuhkan untuk bertahan dalam era globalisasi. Hasil belajar kognitif menjadi dasar yang krusial untuk melakukan pengembangan dalam hal yang lebih tinggi. Penelitian ini bertujuan untuk memberikan gambaran keterampilan kolaborasi, kreativitas mahasiswa, dan hasil belajar kognitif dalam pembelajaran proyek. Penelitian ini menggunakan metode deskriptif kuantitatif. Instrument yang digunakan adalah lembar observasi keterampilan kolaborasi, tes uraian kreativitas, dan tes uraian hasil belajar kognitif. Data dianalisis menggunakan nilai rerata. Hasil penelitian menunjukkan bahwa aspek keterampilan kolaborasi mahasiswa tertinggi yaitu pada aspek bekerja produktif dan tanggung jawab dengan kategori sangat baik. Sedangkan terendah pada aspek kompromi. Kreativitas mahasiswa tertinggi pada aspek rasa ingin tahu, kelancaran berpikir, elaborasi dengan kategori sangat baik. Sedangkan terendah pada aspek berpikir divergen. Hasil belajar kognitif tertinggi pada domain mengaplikasi, sedangkan terendah pada aspek mengevaluasi. Oleh karena itu dapat direkomendasikan bahwa pembelajaran berbasis proyek dapat memberdayakan keterampilan kolaborasi, kreativitas, dan meningkatkan hasil belajar kognitif.