bluuebunny/crossref_metadata_2025 huggingface dataset:
Study on thermodynamics and dynamics of top slag modification in O5 automobile sheets
Authors: Li Shujun , Du Xueyan
Published: August 2022

This article presents a new Ruhrstahl–Heraeus top slag modifier with an enhanced modification effect at an enterprise producing O5 automobile sheets. To compare the modification effect of the original and new modifiers, the thermodynamic and dynamic conditions of the top slag modification were studied by thermodynamic calculations and dynamic analysis. The results showed that the utilization of both modifiers reduced the total iron (TFe) content in the top slag. The new modifier controlled the CaO/Al2O3 (C/A) and TFe content of the top slag to approximately 1.22–1.30 and 6.07–7.97%, respectively. The adsorption capacity of top slag for inclusions was stronger than that of the top slag modified with the original modifier. The concentrations of Al2O3-type inclusions, Ti
x
O·Al2O3 composite inclusions, and oxide inclusions were reduced by 13.4, 21.2, and 3.4 per cm2 with the new modifier compared with the original modifier. The total oxygen content in molten steel was 2.8 ppm lower than that of the original when the new modifier was used. Moreover, the new modifier exhibited a better dynamic condition on the surface of top slag, as determined by R-G-B numerical analysis. Overall, the new modifier improved the dynamic conditions of top slag modification, reduced top slag oxidation, and effectively improved the cleanliness of the molten steel.
The effect of long-term opioid use on back-specific disability and health-related quality of life in patients with chronic low back pain
Authors: Schultz Matthew J. , Licciardone John C.
Published: August 2022

Context

Opioids are commonly utilized for the treatment of chronic pain. However, research regarding the long-term (≥12 months) outcomes of opioid therapy remains sparse.

Objectives

This study aims to evaluate the effects of long-term opioid therapy on measures of back-specific disability and health-related quality of life in patients with chronic low back pain.

Methods

In this retrospective cohort study, patients with chronic low back pain who reported consistent opioid use or abstinence for at least 12 months while enrolled in the Pain Registry for Epidemiological, Clinical, and Interventional Studies and Innovation Pain Research Registry were classified as long-term opioid users or nonusers, respectively. For comparison, intermediate-term and short-term opioid users and nonusers were also identified. Multiple linear regression analysis was performed to compare back-specific disability (Roland-Morris Disability Questionnaire [RMDQ]) and health-related quality of life (29-item Patient-Reported Outcomes Measurement Information System [PROMIS]) between opioid users and nonusers while controlling for pain intensity, depression, age, body mass index (BMI), and eight common comorbid conditions (herniated disc, sciatica, osteoporosis, osteoarthritis, heart disease, hypertension, diabetes, and asthma). Statistically significant findings were assessed for clinical relevance.

Results

There were 96 long-term opioid users and 204 long-term opioid nonusers. After controlling for potential confounders, long-term opioid use was a predictor of worse back-specific disability (adjusted mean difference=2.85, p<0.001), physical function (adjusted mean difference=−2.90, p=0.001), fatigue (adjusted mean difference=4.32, p=0.001), participation in social roles (adjusted mean difference=−4.10, p<0.001), and pain interference (adjusted mean difference=3.88, p<0.001) outcomes. Intermediate-term opioid use was a predictor of worse back-specific disability (adjusted mean difference=2.41, p<0.001), physical function (adjusted mean difference=−2.26, p=0.003), fatigue (adjusted mean difference=3.70, p=0.002), and sleep disturbance outcomes (adjusted mean difference=3.03, p=0.004), whereas short-term opioid use was a predictor of worse back-specific disability (adjusted mean difference=2.42, p<0.001) and physical function outcomes (adjusted mean difference=−1.90, p<0.001).

Conclusions

The findings of this study are largely consistent with existing literature regarding the outcomes of long-term opioid therapy. Taken in conjunction with the well-established risks of opioid medications, these findings draw into question the utility of long-term opioid therapy for chronic low back pain.
Late onset Bartter syndrome: Bartter syndrome type 2 presenting with isolated nephrocalcinosis and high parathyroid hormone levels mimicking primary hyperparathyroidism
Authors: Yıldız Gizem , Torun Bayram Meral , Çinleti Tayfun , Koç Altuğ , Soylu Alper , Kavukçu Salih
Published: August 2022

Objectives

Nephrocalcinosis is associated with conditions that cause hypercalcemia and the increased urinary excretion of calcium, phosphate, and/or oxalate. A monogenic etiology is found in almost 30% of childhood-onset nephrocalcinosis which is also a common manifestation of primary hyperparathyroidism. We discuss a child with nephrocalcinosis and features mimicking primary hyperparathyroidism.

Case presentation

A 7-year-old girl presented with nephrocalcinosis. Hypercalciuria, hyperphosphaturia, mild hypercalcemia, hypophosphatemia and elevated parathyroid hormone levels along with normal serum creatinine and absence of hypokalemic alkalosis suggested primary hyperparathyroidism. However, she was ultimately diagnosed with Bartter syndrome type 2 based on the presence of homozygous pathogenic variation in KCNJ1gene.

Conclusions

This is the second reported case of late-onset Bartter syndrome type 2 without hypokalemic alkalosis. Patients with Bartter syndrome may present with high parathyroid hormone levels and hypercalcemia in addition to hypercalciuria. Thus, the present case suggests that the KCNJ1 gene should be included in genetic analysis even in older children with isolated nephrocalcinosis.
Factors influencing reduced penetrance and variable expressivity in X-linked dystonia-parkinsonism
Authors: Pozojevic Jelena , von Holt Björn-Hergen , Westenberger Ana
Published: August 2022

X-linked dystonia-parkinsonism (XDP) is a neurodegenerative movement disorder that primarily affects adult Filipino men. It is caused by a founder retrotransposon insertion in TAF1 that contains a hexanucleotide repeat, the number of which differs among the patients and correlates with the age at disease onset (AAO) and other clinical parameters. A recent work has identified additional genetic modifiers of age-associated penetrance in XDP, bringing to light the DNA mismatch repair genes MSH3 and PMS2. Despite X-linked recessive inheritance, a minor subset of patients are female, manifesting the disease via various mechanisms such as homozygosity, imbalanced X-chromosome inactivation, or aneuploidy. Here, we summarize and discuss clinical and genetic aspects of XDP, with a focus on variable disease expressivity as a consequence of subtle genetic differences within a seemingly homogenous population of patients.
The crystal structure of 4,4′-dichloro-6,6′-dimethoxy-2,2′,3,3′,5,5′- hexanitroazobenzene, C14H6N8O14Cl2
Authors: Xiao Li , GuoLiang Jin , JinFeng He , JiHui Zhang , Lizhen Chen , JianLong Wang
Published: August 2022

C14H6N8O14Cl2, orthorhombic, Fdd2 (no. 43), a = 21.2891(12) Å, b = 39.532(3) Å, c = 5.1686(3) Å, V = 4349.9(4) Å3, Z = 8, R
gt(F) = 0.0469, wR

ref
(F
2) = 0.1051, T = 140 K.
Stability of voriconazole 10 mg/mL ophthalmic solution during 90 days
Authors: Khan Aasfa , Venet Arnaud , Bernadou Jean-Marc , Cresto Sylvie , Servant Vincent , Boulestreau Hélène , Xuereb Fabien , Crauste-Manciet Sylvie
Published: August 2022

Objectives

Fungal keratitis is a rare but severe cause of infectious keratitis and can lead to blindness. To cure fungal keratitis, antifungal like voriconazole eye drops must be immediately administered. As no brand is available on the market, voriconazole ophthalmic solution is compounded in hospital pharmacies using voriconazole powder for intravenous infusion. The aims of our study were to both assess the physico-chemical and microbiological stability of eye drop solutions stored at +2 to 8 °C. Two different High-Density-Polyethylene (HDPE) eye drop dispensing containers were assessed, one with a sterility preserving cap Novelia®(Nemera) and the other without sterility preserving cap both provided by CAT laboratory. In addition microbiological quality was assessed during 15 days simulated patient use.

Methods

Multiple batches of voriconazole 10 mg/mL eye drops were prepared and stored at +2 to 8 °C to study their stability over 90 days. All analyses were performed in triplicate. Physical stability was determined, pH determination, osmolarity measurement, and a particle count test was also performed. A high performance liquid chromatography (HPLC-UV) stability indicating method was used to determine chemical stability of the ophthalmic solution over 90 days of storage. For microbiological stability, a sterility test was performed using closed membrane filtration method (Steritest®, Merck Millipore) at D0, D90 and D90+15 days after simulated administration of eye drops (D90+15).

Results

For both containers, no variation of visual aspect, pH, osmolality, particle count and final concentration were observed. No microbiological growth was observed after 90 days of storage. At the end of the simulated administration period (D+15), unconstant microbiological growth was only observed in HDPE vials without sterility preserving cap, whereas HDPE vials with a sterility preserving cap Novelia®(Nemera) remained sterile.

Conclusions

Voriconazole 10 mg/mL ophtalmic solution was stable during 90 days at +2 to 8 °C in lightproof HDPE vials without sterility preserving cap and HDPE vials with a sterility preserving cap Novelia®(Nemera). However, vials with classical cap which are not airtight systems, may microbiologically contaminated during patient’s use than vials with Novelia® cap thanks to their innovative valve system.
Questioning Chinese government officials on a live broadcast TV program: shifted second-person pronouns and journalists’ stance and identity
Authors: Zhou Yan
Published: August 2022

It has been recognized that Mandarin speakers use the neutral form (ni) and the honorific form (nin) of second-person pronouns to refer to others based on the social distance and power dynamics between the speakers. Drawing on eighteen hours of journalist-government official conversations in live broadcast TV programs, this study shows that the journalists often shift between the two forms of second-person pronouns when referring to government officials and that the shifts in the two directions appear in different sequential environments. Incorporating the stance triangle model and membership categorization devices, the findings reveal that the shifts indicate changes in the journalists’ self-categorization and their evaluative stances toward the officials in the conversation. The shift from nin to ni tends to occur in the main actions where the interviewer has previously displayed a positive stance but shifts to a negative stance while holding the official accountable; the shift from ni to nin is often used rhetorically to help construct the inconsistencies and self-contradictions of the officials, which also indicates a negative stance.
KEEFEKTIFAN MODEL MIND MAPPING BERBANTUAN GAMBAR TERHADAP KETERAMPILAN MENULIS PUISI
Authors: Amalia Firdausya
Published: August 2022

Berdasarkan prapenelitian di SDN Gugus Wahid Hasyim, Kabupaten Kendal, ditemukan permasalahan rendahnya keterampilan menulis puisi sehingga mengakibatkan rendahnya hasil belajar bahasa Indonesia khususnya materi menulis puisi. Penelitian ini bertujuan untuk menguji keefektifan model pembelajaran mind mapping terhadap keterampilan menulis puisi kelas IV.Penelitian yang dilakukan menggunakan metode kuantitatif jenis eksperimen dengan desain nonequivalent control group design. Teknik sampel yang digunakan adalah simple random sampling, dengan sampel sebanyak 52 siswa. Pengumpulan data menggunakan tes dan dokumentasi. Hasil uji hipotesis menunjukkan bahwa nilai signifikansi sebesar 0,007<0,05 sehingga Ho ditolak. Hasil penelitian menunjukkan terdapat perbedaan rata-rata nilai keterampilan menulis puisi pada pretest dan posttest. Sehingga, dapat disimpulkan bahwa model mind mapping efektif terhadap keterampilan menulis puisi siswa kelas IV SDN Gugus Wahid Hasyim Kabupaten Kendal.

 

Based on pre-research at Wahid Hasyim Cluster Elementary School, Kendal Regency, it was found that there was a problem  on poetry sriting skills resulted in low learning outcomes in Bahasa Indonesia subject. This study aimed to test the effectiveness of the mind mapping learning model on the fourth grade of poetry writing skills. The research used a quantitative method of experimental type with a nonequivalent control group design. The sample technique used simple random sampling, with a sample of 52 students. The data collection techniques used tests and documentation. The hypothesis test r.esults showed that the significance value was 0.007 <0.05 so that Ho was rejected. The results showed that there were differences in the average score of poetry writing skills at the pretest and posttest. So, it can be concluded that the mind mapping model was effective on poetry writing skills of the fourth grade at Wahid Hasyim Cluster Elementary School, Kendal Regency.
PENGEMBANGAN MEDIA PERMAINAN TRADISIONAL DAKON BERBASIS TEORI BRUNER
Authors: Supriyanto Slamet
Published: August 2022

Tujuan penelitian ini untuk mengembangkan, menguji kelayakan dan keefektifan media permainan tradisional dakon berbasis teori Bruner. Jenis penelitian ini adalah penelitian pengembangan metode Research and Development Sugiyono. 1 set permainan terdiri dari empat perangkat permainan. Kartu permainan berisikan operasi hitung pembagian. Hasil penilaian ahli materi sebesar 80% (layak) dan ahli media 84% (sangat layak). Hasil belajar menunjukan ketuntasan belajar lebih dari 75%. Media menghasilkan perbedaan rata-rata (t-test) pada uji coba produk 10,58 uji pemakaian 14,44 dan peningkatan hasil belajar (n-gain) pada uji coba produk 0,47 (sedang) dan uji pemakaian 0,78 (tinggi). Jadi, dapat disimpulkan bahwa media permainan tradisional dakon berbasis teori Bruner mata pelajaran matematika materi operasi hitung pembagian bilangan cacah kelas III SD efektif dan layak digunakan.

 

The objectives of this study were to develop, to test appropriateness and effectiveness of traditional game media based on Bruner theory. This type of study was Sugiyono's Research and Development (R&D). One set of game consisted of four game devices. The game card contain the division calculation operation. The material expert assessment result was 80% (feasible) and the media expert was 84% (very feasible). The learning outcomes showed that learning completeness reached more than 75%. The media produced an average difference (t-test) in the product test that was 10.58, input test was 14.44 and the learning outcomes enhancement (n-gain) in the product test was 0.47 (medium) and input test was 0.78 (high). Thus, it could be concluded that the traditional dakon game media based on Bruner theory on division calculation operation in mathematics subject matter of three-grade students was effective and feasible to use.
Keefektifan Model CTL Terhadap Hasil Belajar Membatik Siswa Kelas V
Authors: Ningrum Fitri Widya
Published: August 2022

AbstrakBatik merupakan salah satu warisan bangsa Indonesia yang dikagumi oleh masyarakat dunia. Pada abad 19 batik mulai sangat berkembang dan melekat di jawa, namun seiring berangsurnya waktu, batik mulai menyebar ke berbagai daerah di Indonesia bahkan ke Mancanegara. Berdasarkan hasil observasi, wawancara, serta data dokumen hasil belajar siswa kelas V didapat bahwa hasil belajar membatik kurang maksimal dikarenakan pembelajaran belum menggunakan media yang praktis, yaitu canting dan lilin panas, guru cenderung menggunakan model yang membuat siswa pasif, sehingga perlu penerapan model CTL. Tujuan penelitian ini yaitu menguji keefektifan model CTL berbantuan media lilin dingin terhadap hasil belajar membatik dan mendeskripsikan aktivitas siswa dalam pembelajaran membatik. Jenis penelitian ini adalah quasi experimental. Teknik pengumpulan data menggunakan tes dan non tes. Analisis data penelitian yaitu uji normalitas, homogenitas, hypothesis, dan n-gain. Hasil uji hipotesis menunjukkan bahwa nilai thitung 5,591, lebih besar dari ttabel 1,998. Hasil uji peningkatan rata-rata N-gain data untuk kelas kontrol sebesar 0,2912 termasuk dalam kriteria rendah, sedangkan untuk kelas eksperimen sebesar 0,5419 termasuk dalam kriteria sedang. Simpulan penelitian adalah model CTL berbantuan media lilin dingin efektif digunakan pada pembelajaran membatik

Batik is one of Indonesian cultural heritages that admired by the world community. In the 19th century batik became highly developed and was well ingrained in java, but over the time, batik has spreadout to various regions in Indonesia and even abroad. Based on observations, interviews, and learning outcomes of batik in 5th grade, it is found that the learning outcomes of batik was not optimal because it was not used the appropiate media, namely canting and hot wax, teachers tend to use models that make students passive, so it is necessary to apply the CTL model. The study aimed to examine the effectiveness of CTL model for batikâ€™s learning outcomes assisted by cold wax media and to describe student activities of batik learning. Analysis of research data were used normality tests, homogenity tests, hypothesis tests, and N-Gain tests. the type of this research was quasi experimental. The data collection techniques were tests and non tests. Hypothesis test results obtained tcount 5.591 greater than ttable 1.998. The increase in test results of the average n-gain data for control class obtained 0.2912 included in the low criteria, while experiment class obtained 0,5419 included in the medium criteria. The conclusion of this research that CTL model is effective for batik learning.
PENGEMBANGAN APLIKASI ADOBE FLASH UNTUK MENINGKATKAN HASIL BELAJAR MATEMATIKA KELAS V
Authors: Sasmita Lisa Dwi
Published: August 2022

Penelitian ini bertujuan untuk mengembangkan media pembelajaran, menguji kelayakan dan keefektifan media berbasis multimedia adobe flash  pada materi jaring-jaring kubus dan balok kelas V SD Negeri Candi. Metode yang digunakan dalam penelitian ini Research and Development (R&D). Hasil penelitian menunjukkan media pembelajaran berbasis multimedia adobe flash  dapat digunakan dalam pembelajaran berdasarkan penilaian ahli materi didapatkan presentase 74% dan ahli media 75% dalam kategori layak. Hasil penelitian pada media pembelajaran berbasis multimedia adobe flash efektif digunakan sesuai dengan hasil yang diperoleh nilai  = 4,867 dan  = 2,045  . Dari hasil perhitungan diperoleh  = 4,867 > = 2,045 maka H0 ditolak dan Ha diterima. Hasil uji gain dari data yang didapatkan data N-gain sebesar 0,34 dengan kriteria sedang. Simpulan penelitian ini adalah media pembelajaran berbasis multimedia adobe flash pada mata pelajaran Matematika materi jaring-jaring kubus dan balok layak digunakan dan efektif meningkatkan hasil belajar Matematika siswa kelas V SD Negeri Candi.

This study aimed to develop instructional media, test the viability and effectiveness of adobe flash-based multimedia on cube and block nets for the fifth students at Candi Elementary School. The method used Research and Development (R&D). The results showed that adobe flash-based multimedia can be used in learning based on the content expert's assessment obtained a percentage of 74% and by media expert assessment obtained a percentage of 75%, both in viable category. The results of the adobe flash-based mulmimedia was effectively used in accordance with the results obtained with the value = 4,867 and = 2,045. From the calculation, obtained = 4,867> = 2,045, so, H0 was rejected and Ha was accepted. The results of N-gain data was 0.34 in moderate criteria. The conclusion of this research was that the Adobe Flash-based multimedia was viable and effective to improve the mathematics learning outcomes of 5th students at Candi Elementary School.
KEEFEKTIFAN MODEL COOPERATIVE SCRIPT MEDIA MIND MAP TERHADAP KEMAMPUAN MENGGALI INFORMASI PENTING
Authors: Subekti Hanum Ari , Nuryanto Sukarir
Published: August 2022

Abstrak

 

Penelitian ini bertujuan untuk mengetahui keefektifan model Cooperative Script dengan media mind map terhadap hasil belajar menggali informasi penting dan mendeskripsikan peningkatan hasil belajar siswa kelas V SDN Gugus Arjuna Kota Semarang. Jenis penelitian ini adalah quasi eksperimental design. Teknik pengumpulan data yang digunakan adalah observasi dan tes. Pengujian hipotesis menggunakan Uji t-test polled varians. Hasil penelitian diperoleh nilai pretes dan postes kelas kontrol dan kelas eksperimen berdistribusi normal dan homogen. Rata-rata nilai posttest kelas   eksperimen lebih besar daripada kelas kontrol. Rata-rata nilai posttest kelas eksperimen adalah 79,1 dan nilai rata-rata posttest kelas kontrol sebesar 75,9. Hasil uji-t menunjukkan nilai thitung2,476 > ttabel1,669 dapat diartikan bahwa hasil belajar siswa kelas ekperimen lebih besar dibandingkan kelas kontrol.Selanjutnya, rata-rata N-gain kelaskontrol 0,15139 lebihkecildari rata-rata N-gain kelaseksperimenyaitu 0,3051. Saran yang dapat disampaikan pada guru yaitu, hendaknya memilih model dan media pembelajaran yang dapat melatih tanggung jawab dan memberikan motivasi kepada siswa untuk aktif. Model cooperative script dan media mind map diharapkan dapat menjadi model dan media yang dapat meningkatkan hasil belajar siswa.

This study aimed to determine the effectiveness of the Cooperative Script model with mind map media on important information digging and to describe the improvement in learning outcomes of fifth grade students at Arjuna Cluster Elementary School Semarang City. This research used quasi experimental design. The data collection techniques used observation and tests. The hypothesis testing used t-test polled variance. The results showed that the pretest and posttest scores for the control class and the experimental class were normally distributed and homogeneous. The average posttest score of the experimental class was higher than the control class. The average posttest score for the experimental class was 79.1 and the posttest mean score for the control class was 75.9. The results of the t-test showed that the value of tcount 2.476> t table 1.669 means that the learning outcomes of the experimental class students were higher than the control class. Furthermore, the control class N-gain average 0.15139 was smaller than the experimental class N-gain average which obtained 0.3051. It was suggested to the teacher to choose learning model and media that can train responsibility and provide motivation for students to be active. Cooperative script model and mind map media were both expected to be the model and media that can improve students' learning outcomes.
KEEFEKTIFAN MODEL PEMBELAJARAN SAVI BERBANTUAN MEDIA FLASHCARD TERHADAP HASIL BELAJAR TARI APUSE
Authors: Anggriyani Hajijah
Published: August 2022

Abstrak

Penelitian ini dilatarbelakangi belum diterapkannya model pembelajaran SAVI, media pembelajaran kurang dikembangkan, dan kurang optimalnya praktik dalam pembelajaran tari kreasi Apuse. Penelitian ini bertujuan untuk mengetahui keefektifan model pembelajaran SAVI berbantuan media flashcard pada siswa kelas IV. Jenis penelitian ini merupakan Quasi Experimental Design dengan subjek penelitian siswa kelas IV SDN Gugus Melati, Kota Semarang. Teknik pengumpulan data menggunakan tes, wawancara, dan dokumentasi. Analisis hipotesis menggunakan; (1) uji perbedaan rata-rata (uji t pihak kanan); (2) uji N-Gain. Hasil uji hipotesis (1) uji perbedaan dua rata-rata pada hasil belajar thitung 2,91 > ttabel 1,66 menunjukkan bahwa rata-rata hasil belajar kelas eksperimen lebih tinggi dari kelas kontrol. (2) hasil N-Gain pada hasil belajar kogitif kelas eksperimen sebesar 0,47 kriteria sedang dan kelas kontrol 0,36 kriteria sedang, sedangkan pada hasil belajar keterampilan kelas eksperimen sebesar 0,36 kriteria sedang dan kelas kontrol 0,35 kriteria sedang. Kesimpulannya model pembelajaran SAVI berbantuan media flashcard efektif meningkatkan hasil belajar tari kreasi Apuse.

The background of this research is that the SAVI learning model has not been applied, the learning media is underdeveloped, and the practice is not optimal in learning the dance creations of Apuse. This study aims to determine the effectiveness of the SAVI learning  model assisted by flashcard media in grade IV students. This type of research is a Quasi Experimental Design with the research subjects of fourth grade students of SDN Gugus Melati, Semarang City. Data collection techniques using tests, interviews, and documentation. Hypothesis analysis using; (1) average difference test (right side t test); (2) N-Gain test. Hypothesis test results (1) the two mean difference test on learning outcomes tcount 2.91> ttable 1.66 shows that the average learning outcomes of the experimental class are higher than the control class. (2) the N-Gain results on the cognitive learning outcomes of the experimental class were 0.47 moderate criteria and the control class was 0.36 moderate criteria, while the experimental class skills learning outcomes were 0.36 moderate criteria and 0.35 moderate criteria for the control class. In conclusion, the SAVI learning model assisted by flashcard media is effective in improving the learning outcomes of Apuse's creations.
HUBUNGAN KEMAMPUAN BERPIKIR KRITIS DAN PERCAYA DIRI DENGAN PRESTASI BELAJAR IPS
Authors: Zulfa Indana
Published: August 2022

Abstrak

Tujuan penelitian ini adalah untuk  menguji hubungan antara kemampuan berpikir kritis dan percaya diri dengan prestasi belajar IPS siswa kelas V SDN Gugus Patimura Kecamatan Tanggungharjo Grobogan. Jenis penelitian ini adalah penelitian korelasi. Populasi dalam penelitian ini adalah siswa kelas V SDN Gugus Patimura Kecamatan Tanggungharjo Grobogan berjumlah 112 siswa. Teknik pengambilan sampel menggunakan Sampling Jenuh. Teknik pengumpulan data menggunakan angket, tes, dokumentasi, dan wawancara. Uji instrumen dilakukan dengan uji validitas, reliabilitas, indeks kesukaran dan daya beda soal. Uji prasyarat analisis dengan menggunakan uji normalitas, linieritas, dan multikolinieritas. Sedangkan teknik analisis data dengan statistik deskriptif, analisis korelasi Product Moment, analisis korelasi ganda, uji signifikan, dan koefisien determinasi. Hasil penelitian menunjukkan bahwa ada  hubungan yang positif dan signifikan antara kemampuan berpikir kritis dan percaya diri secara bersama-sama dengan prestasi belajar IPS, kontribusi variabel kemampuan berpikir kritis dan percaya diri dengan prestasi belajar IPS tersebut termasuk dalam kategori kuat.

This study aims to examine the correlation between critical thinking ability and self confidence with social studies learning achievement of fifth grade students of SDN Gugus Patimura, Tanggungharjo Subdistrict, Grobogan. The type of this research was correlation study. The population in this study were students of fifth grade of SDN Gugus Patimura, Tanggungharjo Subdistrict, Grobogan,  amounted to 112 students. The sampling technique used Saturated Sampling. Data collection techniques used questionnaires, tests, documentation, and interviews. The instrument test was done by using validity, reliability, difficulty index, and difference power question. The prerequisite analysis test used the normality, linearity, and multicollinearity tests. While the data analysis technique used descriptive statistics, Product Moment correlation analysis, multiple correlation analysis, significant test, and the coefficient of determination. The results showed that there was a positive and significant correlation between critical thinking ability and self confidence with social studies learning achievement. The contribution of the variable critical thinking ability and self confidence with social studies learning achievement was in the strong category.
PENGEMBANGAN MEDIA PEMBELAJARAN BERBASIS LECTORA INSPIRE MATERI TARI KREASI DAERAH
Authors: Lestari Wahyu Tri
Published: August 2022

Tujuan dari penelitian ini adalah mengembangkan media pembelajaran berbasis lectora inspire yang layak dalam pembelajaran SBdP. Penelitian ini merupakan jenis penelitian Research and development (penelitian dan pengembangan) adaptasi dari Sugiyono, dengan langkah meliputi: potensi dan masalah, pengumpulan data, desain produk, validasi desain, revisi desain, dan revisi produk. Adapun teknik pengumpulan data yang dilakukan adalah teknik nontes meliputi observasi, wawancara, angket,dan dokumentasi. Subjek penelitian ini adalah siswa kelas IV SDN 4 Sukorejo berjumlah 24 siswa. Hasil penelitian menunjukkan bahwa media pembelajaran  berbasis lectora inspire dinyatakan layak oleh ahli materi dan ahli media dengan persentase komponen kelayakan isi materi oleh ahli materi 1 dan 2 yaitu 76,25% dan 75%  dengan kriteria layak dan komponen penyajian media oleh ahli media 1 dan ahli media 2 yaitu 92,18% dan 96,87% dengan kriteria sangat layak. Simpulan penelitian ini adalah media pembelajaran berbasis lectora inspire pada muatan SBdP layak digunakan dalam pembelajaran SBdP pada materi tari kreasi daerah.

The purpose of this study is to develop appropriate lectora inspire-based learning media in SBdP learning. This research is a type of research and development (research and development) adaptation of Sugiyono, with steps including: potentials and problems, data collection, product design, design validation, design revision, and product revision. The data collection technique used is non-test techniques including observation, interviews, questionnaires, and documentation. The subjects of this study were 24 students of grade IV SDN 4 Sukorejo. The results showed that the lectora inspire-based learning media was declared feasible by material experts and media experts with the percentage of material content feasibility components by material experts 1 and 2, namely 76.25% and 75% with appropriate criteria and media presentation components by media experts 1 and experts. Media 2, namely 92.18% and 96.87% with very feasible criteria. The conclusion of this research is that learning media based on lectora inspire on SBdP content is suitable for use in SBdP learning on regional creation dance material.
KEEFEKTIFAN MODEL CIRC BERBANTUAN PAPAN SELIP TERHADAP PENGUASAAN KOSAKATA SISWA KELAS III
Authors: Khusna Viki Azimatul
Published: August 2022

Abstrak

Penelitian ini bertujuan untuk menguji keefektifan model cooperative integrated reading and composition (CIRC) berbantuan media papan selip terhadap penguasaan kosakata siswa.Penelitian ini mengguna-kan metode kuantitatif. Jenis penelitian ini adalah penelitian eksperimen dengan desain pene-litian quasi experimental. Prosedur penelitian menggunakan non equivalent control group de-sign. Populasi penelitian ini adalah siswa kelas III SD di Gugus Wolter Monginsidi. Teknik pengambilan sampel adalah cluster random sampling dengan SDN 02 Mororejo sebagai kelas eksperimen dan SDN 03 Sarirejo sebagai kelas kontrol. Pengumpulan data menggunakan tek-nik tes, observasi, wawancara, dan dokumentasi. Hasil uji hipotesis menggunakan Indepen-dent Sample T-Test menunjukan bahwa nilai ð‘¡â„Žð‘–ð‘¡ð‘¢ð‘›ð‘” (4,569) > ð‘¡ð‘¡ð‘Žð‘ð‘’ð‘™ (1,9967), artinya hasil tes yang di-peroleh kelas eksperimen lebih besar dibandingkan kelas kontrol. Hail ini di-dukung dengan hasil uji N-gain, yaitu kelas eksperimen berada pada kriteria sedang (0,39) dan kelas kontrol berada pada kriteria rendah (0,25). Observasi aktifitas siswa menunjukan rata-rata kelas eksperimen lebih tinggi yaitu 82,50% dibandingkan kelas kontrol yaitu 76,56%. Berdasarkan hasil penelitian tersebut dapat disimpulkan bahwa model pembelajaran CIRC berbantuan media papan selip efektif terhadap peningkatan penguasaan kosakata dan aktivitas siswa kelas III SD di Gugus Wolter Monginsidi.

This study aims to test the effectiveness of cooperative integrated reading and composition (CIRC) models assisted by slot board media on the studentâ€™s vocabulary mastery. This experiment used quantitative method. The kind of this experimen is quasi experimental desaign. The prosedure of the experiment used non-equivalent control group design. The population of this experiment is the third grade of elementary school in Gugus Wolter Monginsidi. The technique of taking sample is cluster random sampling with SDN 02 Mororejo as experimental class and SDN 03 Sarirejo as control class. Data collection used test technique, observation, interview and documentation techniques. The result of hypothesis used independent sample T-test offers that the score of ð‘¡count (4,569) >ð‘¡ð‘¡ð‘Žð‘ð‘’ð‘™ (1,9967), it means the test results of the experimental class bigger than the control class. This was supported with the result of the N-Gain test, that is the experimental class was in medium criteria (0,424) and the control class was in low criteria (0,233). Observation of studentâ€™s activity refers to average of experiment class is higher that is 82,50% if compared with control class that is 76,56%. Based on the research results, it can be concluded that CIRC learning model assisted by slot board media is effective in improving vocabulary mastery and students activities at the third grade of elementary schools in Gugus Wolter Monginsidi.
NETest: serial liquid biopsies in gastroenteropancreatic NET surveillance
Authors: van Treijen Mark J C , Korse Catharina M , Verbeek Wieke H , Tesselaar Margot E T , Valk Gerlof D
Published: August 2022

Objective

Up to now, serial NETest measurements in individuals assessing the disease course of gastroenteropancreatic neuroendocrine tumors (GEPNETs) at long-term follow-up and treatment response were not studied.

Design

The study was a longitudinal validation study of serial NETest measurements – a blood-based gene expression signature – in 132 patients with GEPNETs on therapy or watch-and-wait strategy.

Methods

Serial samples were collected during 46 (range: 6–71) months of follow-up. NETest scores were compared with Response Evaluation Criteria in Solid Tumors version 1.1-defined treatment response (e.g. no evidence of disease (NED), stable disease (SD) or progressive disease (PD)).

Results

Consecutive NETest scores fluctuated substantially (range: 0–100) over time in individuals with SD (n = 28) and NED (n = 30). Follow-up samples were significantly higher in SD (samples 3–5) and NED subgroups (samples 2–5) compared with baseline results, without changes in imaging. In 82% of untreated patients with PD, consecutive NETest scores consistently remained high. In patients undergoing systemic treatment, the median pre-treatment NETest score in treatment-responders was 76.5 (n = 22) vs 33 (n = 12) in non-responders (P = 0.001). Patients with low pre-treatment scores had 21 months reduced progression-free survival (10 vs 31 months; P = 0.01). The accuracy of the NETest for treatment response prediction was 0.73 (P = 0.009).

Conclusion

In patients not undergoing treatment, consecutive low NETest scores are associated with indolent behavior. Patients who develop PD exhibit elevated scores. Elevated results have important predictive value for treatment responsiveness and could be used for individualizing decisions on systemic therapy. The clinical value of follow-up NETest scores for patients who choose to watch and wait requires further study.
Rapid ovarian transcript changes during the onset of premature ovarian insufficiency in a mouse model
Authors: Kaune Heidy , Montiel Juan F , Fenwick Mark , Williams Suzannah A
Published: August 2022

Premature ovarian insufficiency (POI) affects 1-3% of women under 40 years of age. The identified causes are highly heterogeneous, and 70% of the cases are idiopathic. The ovarian manifestation varies from a variable population of follicles that fail to develop (follicular POI) to the absence of follicles (afollicular POI) with a transition from one to the other over time. Previously, we have described a mouse model of POI that results from an oocyte-specific deletion of N- and O-glycans; Double Mutant (DM). DM females produce only one litter before undergoing POI due to ovarian dysfunction. In this study, we have characterised the gene expression profile of prepuberal (3 weeks), fertile (6 weeks) and infertile (9 weeks) DM ovaries. Up-regulation of cathepsin K (Ctsk, with unknown ovarian function) seems to trigger transcriptional changes in DM ovaries. Significant transcriptional changes then occur rapidly, associated with morphophysiological changes displayed by DM mice throughout the onset of POI. We identified genetic pathways such as extracellular matrix and immune response as candidates for the onset of POI in DM females. Remarkably, DM mice and POI women share a set of differentially expressed genes, including a functionally and co-expressed network of Mcm (minichromosome maintenance proteins) family members. The transcriptomic profile of the DM mouse model provides novel insight into the aetiology of POI.

Lay summary

Problems in ovary function lead to reduced fertility or infertility. One such condition is premature ovarian insufficiency (POI) which affects 1% of women under 40 years of age, and in over 70% of these, the cause of POI is unknown. To investigate POI, we have developed a mouse model. These mice are initially fertile but develop POI by 3 months of age. In this study, we investigated the changes in genes activated in the ovaries during the transition from fertility to POI, and we did this by comparing them to normal mice; gene activation leads to molecule production. A molecule known as cathepsin K seems to trigger changes during the onset of POI, followed by others related to structure and immune response pathways. In addition, some genes were identified that are similar between the POI mice and POI women.
Legible, visible, conspicuous: disabled ingenuity and “ability accommodations” in the disability memoir
Authors: Callanan Andreae
Published: August 2022

First-person accounts of disability and chronic illness have been foundational to the development of disability studies and disability activism. The production of the literary disability memoir places certain rhetorical demands on its author, requiring the memoirist to “translate” their unique experiences as a disabled subject into language the nondisabled reader is equipped to understand. Using key concepts from disabled writers Eli Clare and Neil Marcus, the essay evaluates the disability memoir as a piece of assistive technology produced not for disabled people, but by disabled writers for the benefit of the reader whose embodied experience of disability and chronic illness is limited. These “accessibility accommodations” serve to mitigate the effects of experiential limitation in order to facilitate nondisabled readers’ engagement with disabled ways of being and knowing. The essay offers an overview of rhetorical strategies disabled memoirists use to make their narratives accessible, and surveys examples of literary memoir from authors writing from and through different mental, neurological, and physical conditions. I argue that adapting a first-person account of disability for the page results in a necessary, unavoidable disembodiment of the author’s story; this disembodiment is not a failure of the author to represent their lives fully and accurately, but rather an ingenious innovation on the part of disabled, chronically ill, terminally ill, and neurodivergent writers. As assistive technology, the disability memoir subverts of the typical disabled-nondisabled power dynamic, placing the nondisabled reader on the receiving end of the disabled author’s accommodations.
Behind the Paintbrush: Understanding the Impact of Visual Arts-Based Research (ABR) in the Lives of Disabled Children and Youth as well as Methodological Insights in ABR Application
Authors: Moola Fiona J. , Buliung Ron , Posa Stephanie , Moothathamby Nivatha , Woodgate Roberta L. , Hansen Nancy , Ross Tim
Published: August 2022

Arts-based research (ABR) makes many promises, including the opportunity to engage with embodied ways of being and knowing, raise social and political concerns, as well as to address novel, participant-led inquiries. In this critical narrative review of the literature, we examine how disabled children and youth employ ABR methods in research contexts by carefully examining studies that use visual ABR. A secondary aim is to glean methodological insights from the application of ABR to the lives of disabled children and youth to help foster this critical dialogue. We decided to undertake this narrative review of the literature to better understand how ABR is used in pediatric disability contexts.
Supraglottic Airways Compared With Face Masks for Neonatal Resuscitation: A Systematic Review
Authors: Yamada Nicole K. , McKinlay Christopher JD , Quek Bin Huey , Schmölzer Georg M. , Wyckoff Myra H. , Liley Helen G. , Rabi Yacov , Weiner Gary M.
Published: August 2022

BACKGROUND AND OBJECTIVES

Positive pressure ventilation (PPV) is the most important component of neonatal resuscitation, but face mask ventilation can be difficult. Compare supraglottic airway devices (SA) with face masks for term and late preterm infants receiving PPV immediately after birth

METHODS

Data sources include Medline, Embase, Cochrane Databases, Database of Abstracts of Reviews of Effects, and Cumulative Index to Nursing and Allied Health Literature. Study selections include randomized, quasi-randomized, interrupted time series, controlled before-after, and cohort studies with English abstracts. Two authors independently extracted data and assessed risk of bias and certainty of evidence. The primary outcome was failure to improve with positive pressure ventilation. When appropriate, data were pooled using fixed effect models.

RESULTS

Meta-analysis of 6 randomized controlled trials (1823 newborn infants) showed that use of an SA decreased the probability of failure to improve with PPV (relative risk 0.24; 95% confidence interval 0.17 to 0.36; P <.001, moderate certainty) and endotracheal intubation (4 randomized controlled trials, 1689 newborn infants) in the delivery room (relative risk 0.34, 95% confidence interval 0.20 to 0.56; P <.001, low certainty). The duration of PPV and time until heart rate >100 beats per minute was shorter with the SA. There was no difference in the use of chest compressions or epinephrine during resuscitation. Certainty of evidence was low or very low for most outcomes.

CONCLUSIONS

Among late preterm and term infants who require resuscitation after birth, ventilation may be more effective if delivered by SA rather than face mask and may reduce the need for endotracheal intubation.
A concepção do ato de narrar representada pela personagem Raimundo Silva, em História do cerco de Lisboa, de José Saramago
Authors: Adorno Karen Lorrany Neves , Oliveira Raquel Trentin
Published: August 2022

Objetivamos, no presente artigo, refletir sobre a concepção do ato de narrar representada pela personagem Raimundo Silva, em História do cerco de Lisboa, de José Saramago. Para isso, buscamos pensar sobre como Raimundo Silva lê as suas experiências antes e depois do seu ato infrator, de colocar um “não no lugar de um “sim” em um documento histórico já consagrado pela tradição. A fim de evidenciar como a teoria pode servir para iluminar a literatura, aproximo-me do romance sob a chave de leitura da chamada teoria ricoeuriana de “A tríplice mimese”, pertencente à obra Tempo e Narrativa (1983 [1994]). Esse corpo teórico se torna importante por tratar da identidade narrativa, em que o ato de narrar, de “pôr-em-intriga” os acontecimentos, constitui a maneira pela qual o sujeito organiza as suas experiências práticas. Esse ponto pode vir a explicar a necessidade imperante de Raimundo Silva de modificar o texto de outrem e, assim, a sua própria identidade, cruzando os limites da sua função de corretor.
Participation in subsistence activities and maintenance of traditional skills among indigenous youth in the South Rupununi, Guyana
Authors: Van Vliet Nathalie , Millar Neal , Melville Alyssa , David Oswin , Ignacio Leroy
Published: August 2022

Over the past few decades, issues including globalization and the transition to the cash economy have increasingly hindered the transmission of Traditional Ecological Knowledge (TEK) in Indigenous communities throughout the world. The imparting of TEK across generations of Indigenous Peoples is essential in sustaining cultural practices and to maintaining their subsistence lifestyles. In this study, we used semi-structure interviews to assess the level of participation in subsistence activities and acquisition of subsistence skills among Indigenous children in Guyana.  We also assessed whether the level of participation or acquisition of skills was explained by location and social characteristics such as age, gender, occupation of mother/father. We found that Indigenous children in the South Rupununi are highly involved in subsistence activities and the majority conserves subsistence related skills.  Traditional gears, such as the bow and arrow are still dominant among Indigenous children in South Rupununi, particularly for hunting purposes, but also for fishing.  Results also suggest that children’s participation (through work or play) in subsistence activities are key to the acquisition of subsistence knowledge and skills. Among indigenous children in South Rupununi, participation to subsistence activities varies according to gender and is linked to the main occupation of the parents. While participation in subsistence activities is primarily motivated by the need to search for food, those activities are also explicitly described as providing opportunities for skill development and as sources of fun or amusement. The study concludes by advocating the need to revive connections to subsistence ways of life and the integration of more situated learning experiences within the regular school curriculum for indigenous youth.
Religion as a Testing Ground for Cognitive Science
Authors: Shtulman Andrew
Published: August 2022

Research at the intersection of cognitive science and religion can illuminate the cognitive underpinnings of religious thought and behavior, as White (2021) persuasively demonstrates in her comprehensive synthesis of CSR research, but this research can also constrain broader theories of cognition. Here, I examine CSR research relevant to a prominent theory of how we represent minds and bodies: intuitive dualism. This theory, which posits that folk psychology and folk physics are not initially integrated in our representations of intentional agents, makes predictions about god concepts and afterlife beliefs that are not supported by empirical research on these topics. Rather, CSR research suggests that dualism varies by culture and context and must be learned. This case study highlights the reciprocal relation between cognitive science and the study of religion and points to the mutual benefits of their integration.
Five Issues in the Debate
Authors: White Claire
Published: August 2022

In this response, I identify and address five recurring issues raised in the commentaries to my recently published book, An Introduction to the Cognitive Science of Religion: Connecting Evolution, Brain, Cognition, and Culture. These issues are: (1) Conceptualizing and studying religion, (2) the dialogue between method and theory, (3) the theological implications of the CSR, (4) history and culture, and finally, I end with (5) the future of religion and the CSR. I conclude that while further developments are inevitable in a subdiscipline as young as the CSR, we have made tremendous progress already in revitalizing the study of religion towards a more scientifically grounded perspective.