bluuebunny/crossref_metadata_2025 huggingface dataset:
Mapping Brain Motor Functions Using Transcranial Magnetic Stimulation with a Volume Conductor Model and Electrophysiological Experiments
Authors: Hikita Keigo , Gomez-Tames Jose , Hirata Akimasa
Published: January 2023

Transcranial magnetic stimulation (TMS) activates brain cells in a noninvasive manner and can be used for mapping brain motor functions. However, the complexity of the brain anatomy prevents the determination of the exact location of the stimulated sites, resulting in the limitation of the spatial resolution of multiple targets. The aim of this study is to map two neighboring muscles in cortical motor areas accurately and quickly. Multiple stimuli were applied to the subject using a TMS stimulator to measure the motor-evoked potentials (MEPs) in the corresponding muscles. For each stimulation condition (coil location and angle), the induced electric field (EF) in the brain was computed using a volume conductor model for an individualized head model of the subject constructed from magnetic resonance images. A post-processing method was implemented to determine a TMS hotspot using EF corresponding to multiple stimuli, considering the amplitude of the measured MEPs. The dependence of the computationally estimated hotspot distribution on two target muscles was evaluated (n = 11). The center of gravity of the first dorsal interosseous cortical representation was lateral to the abductor digiti minimi by a minimum of 2 mm. The localizations were consistent with the putative sites obtained from previous EF-based studies and fMRI studies. The simultaneous cortical mapping of two finger muscles was achieved with only several stimuli, which is one or two orders of magnitude smaller than that in previous studies. Our proposal would be useful in the preoperative mapping of motor or speech areas to plan brain surgery interventions.
The Hometown Is Hard to Leave, the Homesickness Is Unforgettable—The Influence of Homesickness Advertisement on Hometown Brand Citizenship Behavior of Consumers
Authors: Wei Chenwen , Wang Chao , Sun Lili , Xu Anxin , Zheng Manhua
Published: January 2023

The hometown brand is symbolic of a hometown and can induce homesickness in consumers. Especially for those who live in other countries, it can stimulate their inner sense of belonging, self-identity, and effectiveness, in turn generating a series of brand behaviors and promoting sustainable brand development. In this study, we adopt a situational experimental research method from the perspective of sense of place theory and social exchange theory in order to assess the regulatory mechanism of place attachment through the mediating mechanism of psychological ownership. In this way, we explore the mechanism underlying the relationship between homesickness advertising (vs. non-homesickness advertising) on the hometown brand citizenship behavior of consumers. Our findings suggest that (1) homesickness advertising has a more positive effect on consumer hometown brand citizenship behavior than non-homesickness advertising; (2) psychological ownership plays a fully mediating role in the relationship between homesickness advertising (vs. non-homesickness advertising) and consumer hometown brand citizenship behavior; and (3) place attachment plays a moderating role in the influence of homesickness advertising (vs. non-homesickness advertising) on the hometown brand citizenship behavior of consumers through psychological ownership.
Damage Detection in Reinforced Concrete Member Using Local Time-Frequency Transform Applied to Vibration Measurements
Authors: Liu Ning , Schumacher Thomas , Li Yan , Xu Lina , Wang Bo
Published: January 2023

Signal processing and analysis of structural vibration measurements are key components of structural damage detection (SDD) in structural health monitoring (SHM). The goal of signal processing is to extract subtle changes in the measured signals, which can be used to infer changes in structural parameters and damage. Time-frequency analysis is one of the most popular characterization methods for studying non-stationary vibration signals. In this article, the local time-frequency transform (LTFT) is applied and evaluated to calculate the time-domain signals because of its excellent time-frequency energy distribution properties. The LTFT matches the input data by the Fourier basis in an inverse problem framework and uses the least squares method to solve the time-varying Fourier coefficients. Subsequently, it defines the time-frequency spectrum as the calculated time-varying Fourier coefficients. While the LTFT has been used in the field of geophysics for seismic data processing, its application to structural vibration signals is novel. Both synthetic signals as well as signals collected from a large-scale laboratory test of a reinforced concrete girder were processed with the LTFT and compared with Rényi entropy for quantifying the time-frequency spectrum, the time-frequency resolution abilities of short time Fourier transform (STFT), and S transform (ST). The results show that the LTFT is superior to the traditional time-frequency analysis schemes, in that it is more effective in identifying the energy changes in the time-frequency spectrum before and after structural damage in the form of cracking has occurred. At the same time, it provides high-precision time-frequency resolution and excellent noise suppression abilities. The effectiveness and feasibility of the LTFT applied to the synthetic and experimental signals are verified.
Assessment of Thermal Comfort and Air Quality in Office Rooms of a Historic Building: A Case Study in Springtime in Continental Climate
Authors: Ameen Arman , Mattsson Magnus , Boström Hanna , Lindelöw Hanna
Published: January 2023

One of the most important aspects of working in an office environment is ensuring that the space has optimal thermal comfort and an indoor environment. The aim of this research is to investigate the thermal comfort and indoor climate in three office rooms located at one of the campus buildings at the University of Gävle, Sweden. The evaluated period is in the month of April during springtime. During this period, parameters such as temperature, relative humidity, CO2, supply air flow rate, and room air velocities are measured on site. The results of the measurement show that the indoor temperature is on average lower in the rooms facing north, at 21–23.5 °C, compared to the rooms facing south, which reach high temperatures during sunny days, up to 26 °C. The results also show that the ventilation air supply rate is lower than the requirement for offices in two of the office rooms. The ACH rate is also low, at ≈ 1 h−1 for all the rooms, compared to the required levels of 2–4 h−1. The CO2 levels are within the recommended values; on average, the highest is in one of the south-facing rooms, with 768 ppm, and the maximum measured value is also in the same room, with 1273 ppm for a short period of time.
Seismic Design Codes—Key Elements for Seismic Risk Perception and Reduction in Europe
Authors: Pavel Florin
Published: January 2023

Earthquakes are one of the most costly and deadliest natural disasters. This perspective paper presents a discussion focused on the role of seismic design codes in risk perception and seismic risk reduction in Europe. The seismic design codes are a key component for both the design of new buildings, as well as for the vulnerability assessment of existing ones. The impact of seismic design codes on seismic risk reduction is discussed using as case-study countries, Italy, Turkey, Greece, and Romania, which according to the recent European seismic risk model 2020 have the largest expected mean annual losses due to earthquakes. The evaluation of the seismic exposure of the four countries shows that from the entire population of more than 170 million people, about 130 million live in buildings designed using no or low level seismic design. The mean annual expected losses due to earthquakes are of the order of 0.1–0.2% of the national GDP. Moreover, the mean annual death probability due to earthquakes is 10−6 which represents a risk level not of great concern to the average people. However, large earthquakes in Europe from the past 50 years have produced losses in excess of 10 billion Euros and several hundred thousand affected people. A solution for a better communication of seismic risk in order to increase seismic risk perception might be to provide exceedance probabilities of specific macroseismic intensity levels for time frames of 10 or 20 years, instead of annual values. Macroseismic levels from past earthquakes might be used in order to have a better understanding of the results and should complement the seismic design maps. In addition, in the case of seismic vulnerability, the use of simple terms (e.g., inhabitable or uninhabitable) along with their associated occurrence probabilities in the same time frame as in the case of the seismic hazard, might be a solution. Financial incentives for seismic strengthening, as well as a clear definition of an earthquake-prone building are also very useful for increasing seismic risk perception.
Spatial Perception Imperatives in Virtual Environments: Understanding the Impacts of View Usage Patterns on Spatial Design Decisions in Virtual Reality Systems
Authors: Azarby Sahand , Rice Arthur
Published: January 2023

Spatial perception in virtual reality systems relies on a number of variables, including how users explore, observe and perceive the spatial factors of a virtual environment. In virtual reality systems, users can assume different types of views for spatial decision-making about the sizes and scales of and relationships among virtual spaces. This research explored the role of view usage patterns in spatial cognition and decision-making in a fully immersive virtual reality system and monitor-based virtual reality system. The focus of study was the impact of using the eye-level view as the only view type in a fully immersive virtual reality system on actual and perceived view usage patterns in a monitor-based virtual reality system. In addition, users’ spatial decision-making results were compared with regards to system usage sequence and view type. Quantitative and qualitative data, descriptive and inferential statistical comparisons, and testing of both systems were used to determine the participants’ performances concerning view usage patterns and the design outcomes. The results showed a moderate association between the view type utilized for spatial perception in a monitor-based virtual reality system and variations in system usage sequence. In addition, for both systems, variations in system usage sequence, space type, and other characteristics all affected the strength of the linear regressions of the sizes and scales of the design outcomes.
Research on Sustainable Development Model of Chinese Artist Village
Authors: Luo Yun , Xiang Pengcheng , Li Bo
Published: January 2023

As a development form of the creative industry, the Artist Village is a high concern of the Chinese government, and it has achieved rapid developments in China in recent years. However, many Artist Villages come to an untimely end a short period after their birth and fail to realize sustainable development. In this study, an empirical analysis on 80 Artist Villages in China was carried out. A field investigation and research on eight Artist Villages was implemented. Attention was paid to thoroughly analyze three typical Artist Villages of Guangzhou Xiaozhou Artist Village, Chongqing Gujianshan Artist Village and Beijing Songzhuang Artist Village. It has been found from studies that the development of Artist Villages in China has experienced initiation, development and maturity stages. The development of Artist Villages in China generally has many problems, such as an insufficient endogenous impetus, the excessive intervention of government, market capital “squeezing out” the original artists, and so on. This paper proposed a sustainable development model for Artist Villages during urbanization in China based on the findings and conclusions of this study. This study not only enriches research contents in this field, but can also provide meaningful references for the sustainable development of Artist Villages in China.
Assessing Efficiency and Environmental Performance of a Nearly Zero-Energy University Building’s Energy System in Norway
Authors: Abrahamsen Fredrik Ege , Ruud Sturla Grina , Gebremedhin Alemayehu
Published: January 2023

Increasing awareness of climate issues in recent decades has led to new policies on buildings’ energy consumption and energy performance. The European Union (EU) directive 2010/31/EC, i.e., the energy performance of buildings directive (EPBD), is one of the measures initiated to achieve climate and energy goals by reducing energy use and greenhouse gas emissions in the building sector. The EPBD required all new buildings to be nearly zero-energy buildings (nZEBs) by 2021. Nearly zero-energy buildings (nZEBs) are buildings with a very-high-energy performance and nearly zero or low-energy requirements covered to a very significant extent by energy from renewable sources produced on-site or nearby. The utilisation of solar photovoltaic (PV) panels is a common approach for achieving the nZEB standard. The carbon footprint of PV panels is often not discussed as a parameter. This paper aimed to analyse the environmental performance of an existing nearly zero-energy university building in a Norwegian use case scenario. This analysis is performed by assessing annual electricity and heat consumption from both energetic and environmental perspectives. The energy required for the building during the studied period is then used to analyse the environmental and energy performance of the building. When it comes to the environmental assessment, the commercial software SimaPro was used. The proposed revision EPBD and nZEB definition from 2021 suggests that nZEBs should also consider operational greenhouse gas emissions and life-cycle global warming potential from 2027. The life cycle assessment (LCA) of the building’s energy sources looks at the global warming potential (GWP) and greenhouse gas (GHG) emissions, and how they compare to Norwegian grid electricity. The results of the analysis highlights potential challenges to justifying the use of alternative energy sources to fulfil the criteria of nZEBs. When installing solar PV, it is important to consider the energy mix of the country where the solar PVs are produced. To solely consider the energy performance of the building, the installation of solar PV panels in countries with a high share of renewable energy may result in a reduced impact in terms of emission reduction from a life cycle perspective.
Influence of Defoamer on the Properties and Pore Structure of Cementitious Grout for Rebar Sleeve Splicing
Authors: Huang Chunhua , Ding Bo , Ou Zhihua , Feng Ruiping
Published: January 2023

Grout sleeve splicing of rebar is a major technology in prefabricated buildings, and cementitious grout for rebar sleeve splicing (hereinafter called grout) is an essential material for this technology. Grout, with its excellent mechanical properties, improves the stability of rebar sleeve splicing. In this study, the mechanical properties of grout were improved by introducing an admixture in the form of a defoamer, and the influence of the defoamer on the fluidity, loss rate of fluidity, wet apparent density and strength of the grout was investigated. The action of the defoamer in regulating the pore structure of the grout was further analyzed using the mercury intrusion porosimetry (MIP) method. The results showed that when the dosage of defoamer was increased from 0 to 0.025%, the fluidity of the grout initially increased and then decreased, but there was no change in the loss rate at 30 min. The wet apparent density increased continuously, whereas the flexural and compressive strength generally increased initially and then tended to stabilize. The MIP test results showed that the defoamer increased the pore volume of the grout in the range of 6 nm to 30 nm and decreased the pore volume in the range of 30 nm to 60 μm. However, in the 60 μm to 300 μm pore size range, the pore volume increased when the dosage of the defoamer was 0.0025% and 0.0075%, and decreased when the dosage was 0.005% and 0.001%. The porosity of the grout initially decreased and then increased slightly as the dosage of the defoamer increased from 0 to 0.01%. The introduction of defoamer can optimize the pore structure of grout and then improve its mechanical properties. The influence of defoamer on grout properties and pore structure were systemically studied with a view to providing technical and theoretical guidance for rebar sleeve-splicing technology in prefabricated construction.
Catalytic Biomaterials for Atrazine Degradation
Authors: Diviesti Karla , Holz Richard C.
Published: January 2023

In this paper, triazine hydrolase from Arthrobacter aurescens TC1 (TrzN) was successfully immobilized in alginate beads (TrzN:alginate), alginate beads coated in chitosan (TrzN:chitosan), and tetramethylorthosilicate (TMOS) gels using the sol–gel method (TrzN:sol–gel) for the first time. TrzN:alginate and TrzN:chitosan hydrolyzed 50 µM of atrazine in 6 h with negligible protein loss with an ~80% conversion rate. However, the TrzN:sol–gel biomaterial converted >95% of a 50 µM atrazine solution in an hour with negligible protein loss. The treatment of each of these biomaterials with trypsin confirmed that the catalytic activity was due to the encapsulated enzyme and not surface-bound TrzN. All three of the biomaterials showed potential for long-term storage and reuse, with the only limitation arising from the loss of protein in the storage buffer for the TrzN:alginate and TrzN:chitosan biomaterials, not the denaturation of the encapsulated TrzN. TrzN:sol–gel stood out, with ~100% activity being retained after 10 consecutive reactions. Additionally, the materials stayed active in methanol concentrations <10%, suggesting the ability to increase the solubility of atrazine with organic solvents. The structural integrity of the TrzN:alginate and TrzN:chitosan materials became limiting in extreme pH conditions, while TrzN:sol–gel outperformed WT TrzN. Overall, the TrzN:sol–gel biomaterial proved to be the best atrazine dichlorination biocatalyst. As sol–gels can be cast into any desired shape, including pellets, which can be used in columns, the TrzN:sol–gel biomaterial provides a new avenue for the design of bioremediation methodologies for the removal of atrazine from the environment.
Oxygen-Deficient Engineering for Perovskite Oxides in the Application of AOPs: Regulation, Detection, and Reduction Mechanism
Authors: Yu Jiayu , Li Huanhuan , Lin Naipeng , Gong Yishu , Jiang Hu , Chen Jiajia , Wang Yin , Zhang Xiaodong
Published: January 2023

A perovskite catalyst combined with various advanced oxidation processes (AOPs) to treat organic wastewater attracted extensive attention. The physical and chemical catalytic properties of perovskite were largely related to oxygen vacancies (OVs). In this paper, the recent advances in the regulation of OVs in perovskite for enhancing the functionality of the catalyst was reviewed, such as substitution, doping, heat treatment, wet-chemical redox reaction, exsolution, and etching. The techniques of detecting the OVs were also reviewed. An insight was provided into the OVs of perovskite and reduction mechanism in AOPs in this review, which is helpful for the reader to better understand the methods of regulating and detecting OVs in various AOPs.
Fungal Assisted Valorisation of Polymeric Lignin: Mechanism, Enzymes and Perspectives
Authors: Dashora Kavya , Gattupalli Meghana , Tripathi Gyan Datta , Javed Zoya , Singh Shweta , Tuohy Maria , Sarangi Prakash Kumar , Diwan Deepti , Singh Harikesh B. , Gupta Vijai Kumar
Published: January 2023

Lignocellulose is considered one of the significant recalcitrant materials and also is difficult to break down because of its complex structure. Different microbes such as bacteria and fungi are responsible for breaking down these complex lignin structures. This article discussed briefly the lignin-degrading bacteria and their critical steps involved in lignin depolymerization. In addition, fungi are regarded as the ideal microorganism for the degradation of lignin because of their highly effective hydrolytic and oxidative enzyme systems for the breakdown of lignocellulosic materials. The white rot fungi, mainly belonging to basidiomycetes, is the main degrader of lignin among various microorganisms. This could be achieved because of the presence of lignolytic enzymes such as laccases, lignin peroxidases, and manganese peroxidases. The significance of the fungi and lignolytic enzyme’s role in lignin depolymerization, along with its mechanism and chemical pathways, are emphasized in this article.
Cord Blood Plasma and Placental Mesenchymal Stem Cells-Derived Exosomes Increase Ex Vivo Expansion of Human Cord Blood Hematopoietic Stem Cells While Maintaining Their Stemness
Authors: Teleb Rasha S. , Abdul-Hafez Amal , Othman Amira , Ahmed Ahmed El-Abd , Elsaid Abdelrahman A. , Arif Hattan , Zarea Ahmed A. , Abdulmageed Mohammed , Mohamed Hend , Ibrahim Sherif Abdelfattah , Thiruvenkataramani Ranga P. , Mohamed Tarek , Kanada Masamitsu , Madhukar Burra V. , Arellano Myrna Gonzalez , Sayed Mohammed M. , Qubaisy Heba M. , Omar Said A.
Published: January 2023

Background: Mesenchymal stem cells (MSCs) have been used for ex vivo expansion of umbilical cord blood (UCB) hematopoietic stem cells (HSCs) to maintain their primitive characters and long-term reconstitution abilities during transplantation. Therapeutic effects of MSCs mainly rely on paracrine mechanisms, including secretion of exosomes (Exos). The objective of this study was to examine the effect of cord blood plasma (CBP)-derived Exos (CBP Exos) and Placental MSCs-derived Exos (MSCs Exos) on the expansion of UCB HSCs to increase their numbers and keep their primitive characteristics. Methods: CD34+ cells were isolated from UCB, cultured for 10 days, and the expanded HSCs were sub-cultured in semisolid methylcellulose media for primitive colony forming units (CFUs) assay. MSCs were cultured from placental chorionic plates. Results: CBP Exos and MSCs Exos compared with the control group significantly increased the number of total nucleated cells (TNCs), invitro expansion of CD34+ cells, primitive subpopulations of CD34+38+ and CD34+38−Lin− cells (p < 0.001). The expanded cells showed a significantly higher number of total CFUs in the Exos groups (p < 0.01). Conclusion: CBP- and placental-derived exosomes are associated with significant ex vivo expansion of UCB HSCs, while maintaining their primitive characters and may eliminate the need for transplantation of an additional unit of UCB.
Tritrophic Interactions among Arthropod Natural Enemies, Herbivores and Plants Considering Volatile Blends at Different Scale Levels
Authors: Ali Muhammad Yasir , Naseem Tayyaba , Holopainen Jarmo K. , Liu Tongxian , Zhang Jinping , Zhang Feng
Published: January 2023

Herbivore-induced plant volatiles (HIPVs) are released by plants upon damaged or disturbance by phytophagous insects. Plants emit HIPV signals not merely in reaction to tissue damage, but also in response to herbivore salivary secretions, oviposition, and excrement. Although certain volatile chemicals are retained in plant tissues and released rapidly upon damaged, others are synthesized de novo in response to herbivore feeding and emitted not only from damaged tissue but also from nearby by undamaged leaves. HIPVs can be used by predators and parasitoids to locate herbivores at different spatial scales. The HIPV-emitting spatial pattern is dynamic and heterogeneous in nature and influenced by the concentration, chemical makeup, breakdown of the emitted mixes and environmental elements (e.g., turbulence, wind and vegetation) which affect the foraging of biocontrol agents. In addition, sensory capability to detect volatiles and the physical ability to move towards the source were also different between natural enemy individuals. The impacts of HIPVs on arthropod natural enemies have been partially studied at spatial scales, that is why the functions of HIPVs is still subject under much debate. In this review, we summarized the current knowledge and loopholes regarding the role of HIPVs in tritrophic interactions at multiple scale levels. Therefore, we contend that closing these loopholes will make it much easier to use HIPVs for sustainable pest management in agriculture.
Relocalization of Translation Termination and Ribosome Recycling Factors to Stress Granules Coincides with Elevated Stop-Codon Readthrough and Reinitiation Rates upon Oxidative Stress
Authors: Makeeva Desislava S. , Riggs Claire L. , Burakov Anton V. , Ivanov Pavel A. , Kushchenko Artem S. , Bykov Dmitri A. , Popenko Vladimir I. , Prassolov Vladimir S. , Ivanov Pavel V. , Dmitriev Sergey E.
Published: January 2023

Upon oxidative stress, mammalian cells rapidly reprogram their translation. This is accompanied by the formation of stress granules (SGs), cytoplasmic ribonucleoprotein condensates containing untranslated mRNA molecules, RNA-binding proteins, 40S ribosomal subunits, and a set of translation initiation factors. Here we show that arsenite-induced stress causes a dramatic increase in the stop-codon readthrough rate and significantly elevates translation reinitiation levels on uORF-containing and bicistronic mRNAs. We also report the recruitment of translation termination factors eRF1 and eRF3, as well as ribosome recycling and translation reinitiation factors ABCE1, eIF2D, MCT-1, and DENR to SGs upon arsenite treatment. Localization of these factors to SGs may contribute to a rapid resumption of mRNA translation after stress relief and SG disassembly. It may also suggest the presence of post-termination, recycling, or reinitiation complexes in SGs. This new layer of translational control under stress conditions, relying on the altered spatial distribution of translation factors between cellular compartments, is discussed.
Luminescence Tracking and In Vivo Toxicity Evaluation of TiO2 and Europium Doped TiO2 Nanocrystals during Drosophila Development
Authors: de Oliveira Jerusa Maria , da Silva Kellen Talita Romão , dos Santos Francisco Rubens Alves , Valer Felipe Berti , Takaki Ricardo Kenji Ohno , de Carvalho João Paulo Santos , de Castro Olagide Wagner , Rocha Thiago Lopes , Dantas Noelio Oliveira , Silva Anielle Christine Almeida , Anhezini Lucas
Published: January 2023

Titanium dioxide (TiO2) nanoparticles (NPs) are widely used in industry and commercial products. Thus, their potential risks to the environment and human health must be evaluated. Doping NPs with certain ions makes it possible to mix properties or generate new ones. Thus, in order to track TiO2 NPs in biological assays, doping with europium (Eu3+) ions was performed, which luminesce in red. Here, we synthesized TiO2 and Eu3+-doped TiO2 nanocrystals (NCs) in anatase phase to verify the toxicity at different concentrations in Drosophila melanogaster and track the distribution of these NCs in vivo. We verified that the incorporation of europium improved the biocompatibility in relation to the pure samples. The presence of Eu3+-doped TiO2 NCs in the gut, brain, and fat body of larvae and intestinal cells of adult animals was detected. Eu3+-doped TiO2 NCs caused significant larval and pupal mortality rates, in addition to leading to the formation of reactive species, especially at high concentrations. Therefore, our data demonstrated it was possible to trace the Eu3+-doped TiO2 NCs, but TiO2 and Eu3+-doped TiO2 NCs in anatase phase were toxic to fruit flies at the tested concentrations, and should be used with caution to minimize health risks.
Autism Spectrum Disorder in the Dominican Republic: A Mini Review of the Current Situation
Authors: Figuereo Yosauri Fernandez , Lewis Jack , Lee Peyton , Walker Stephen J.
Published: January 2023

As the recognition of autism spectrum disorder (ASD) increases, and the prevalence estimates of ASD continue to rise throughout the world, it has become apparent that access to diagnostic and treatment services is highly dependent on geography. Even within countries such as the United States, which has received significant interest and investment in understanding, diagnosing, treating, and providing programs for those with ASD over the last 20+ years, access to information and services is uneven. In poorer countries such as the Dominican Republic (DR), where >40% of citizens live below the poverty level and access to quality healthcare overall continues to be a challenge, issues associated with ASD are not yet being adequately addressed. The objective of this review is to provide a realistic synopsis of the resources currently available to Dominicans who have a family member or loved one with ASD. We examine the challenges these families face in finding care, the stigma associated with ASD, and programs available for people with ASD. We conclude that while the DR is making progress in its efforts to address ASD, there is still much work to be done.
Importance of Early Intervention in Reducing Autistic Symptoms and Speech–Language Deficits in Children with Autism Spectrum Disorder
Authors: Maksimović Slavica , Marisavljević Maša , Stanojević Nina , Ćirović Milica , Punišić Silvana , Adamović Tatjana , Đorđević Jelena , Krgović Ivan , Subotić Miško
Published: January 2023

The intervention focused on starting treatment at an early age to develop the child’s full potential, which is known as early intervention. Given that autistic symptoms and language deficits occur at an early age and affect other areas of development in children with autistic spectrum disorder, we wanted to examine if early intervention is more effective in the reduction in autistic symptoms and language deficits in children aged 36–47 months old when compared to children 48–60 months old. The sample consisted of 29 children diagnosed with ASD who were admitted for integrative therapy. All participants were divided into two groups based on age: G1: 36–47 months old children, and G2: 48–60 months old children. To estimate the presence of autistic symptoms, we used the GARS-3, and for the assessment of speech–language abilities, we used the subscale Estimated Speech and Language Development (ESLD). Our results regarding the effect of the group on the difference in the scores at two time points showed that there was a statistically significant effect of the group on the reduction in autistic symptoms (p < 0.05) but no effect of the group on the differences in speech–language abilities between the two time points (p > 0.05). Our study highlights the importance of emphasizing the exact age when using the terms “early intervention” and “early development” in future studies and practice because it is necessary to determine and establish guidelines about which particular ages are crucial for starting treatment in certain developmental aspects.
Diagnosing Acute Cellular Rejection after Paediatric Liver Transplantation—Is There Room for Interleukin Profiles?
Authors: Goldschmidt Imeke , Chichelnitskiy Evgeny , Rübsamen Nicole , Jaeger Veronika K. , Karch André , D’Antiga Lorenzo , Di Giorgio Angelo , Nicastro Emanuele , Kelly Deirdre A. , McLin Valerie , Korff Simona , Debray Dominique , Girard Muriel , Hierro Loreto , Klaudel-Dreszler Maja , Markiewicz-Kijewska Malgorzata , Falk Christine , Baumann Ulrich
Published: January 2023

Background: The current gold standard to diagnose T-cell-mediated acute rejection (TCMR) requires liver histology. Using data from the ChilSFree study on immune response after paediatric liver transplantation (pLT), we aimed to assess whether soluble cytokines can serve as an alternative diagnostic tool in children suspected to have TCMR. Methods: A total of n = 53 blood samples obtained on the day of or up to 3 days before liver biopsy performed for suspected TCMR at median 18 days (range 7–427) after pLT in n = 50 children (38% female, age at pLT 1.8 (0.5–17.5) years) were analysed for circulating cytokine levels using Luminex-based Multiplex technology. Diagnostic accuracy of cytokine concentrations was assessed using a multivariable model based on elastic net regression and gradient boosting machine analysis. Results: TCMR was present in 68% of biopsies. There was strong evidence that patients with TCMR had increased levels of soluble CXCL8, CXCL9, CXCL10, IL-16, IL-18, HGF, CCL4, MIF, SCGF-β, and HGF before biopsy. There was some evidence for increased levels of sCD25, ICAM-1, IL-6, IL-3, and CCL11. Diagnostic value of both single cytokine levels and a combination of cytokines and clinical markers was poor, with AUROCs not exceeding 0.7. Conclusion: Patients with TCMR showed raised levels of cytokines and chemokines reflective of T-cell activation and chemotaxis. Despite giving insight into the mechanisms of TCMR, the diagnostic value of soluble cytokines for the confirmation of TCMR in a clinical scenario of suspected TCMR is poor.
The Arctic Winter Seasons 2016 and 2017: Climatological Context and Analysis
Authors: Ionita Monica
Published: January 2023

In this study, we show that the extreme Arctic winter 2015/16 can be partially explained by the superposition of different atmospheric teleconnection patterns, such as the Arctic Oscillation, the Pacific-North American teleconnection, and El Niño—Southern Oscillation, whereas winter 2016/17 had different trigger mechanisms. While the temperature anomalies for winter 2015/16 were mainly driven by the large-scale atmospheric circulation, the temperature anomalies throughout winter 2016/17 may possibly reflect a response to the extremely wet and warm autumn of 2016. The atmospheric circulation anomalies in winter 2016/17 were not as “spectacular” as the ones in the previous winter, but autumn 2016 was one of the most exceptional autumns in the observational record so far and it features some remarkable records: the lowest temperature gradient between the Arctic and the mid-latitudes over the last 70 years, the lowest autumn sea ice extent over the last 40 years, and the warmest and wettest autumn over the last 37 years over most of the Arctic basin. Moreover, we demonstrate that although the background conditions were similar for winters 2015/2016 and 2016/2017 (e.g., reduced sea ice cover, a reduced temperature gradient between the Arctic and the mid-latitudes, and a very warm Barents Sea and Kara Sea in the previous autumn), the response of the atmospheric circulation and the regions affected by extremes (e.g., cold spells and snow cover) were rather different during these two winters.
Habitual Sleep Patterns and Chronic Sleep Problems in Relation to Sex, Age, and Circadian Preference in a Population-Based Sample of Norwegian Adults
Authors: Saxvig Ingvild West , Bjorvatn Bjørn , Waage Siri
Published: January 2023

Sleep patterns and problems vary in relation to internal (e.g., sex, age, circadian preference) and external (e.g., social structures) factors. The main aim of the present study was to describe habitual sleep patterns and chronic sleep problems in a population-based sample of Norwegian adults. During spring 2022, a sample of 1028 adults completed an online survey on sleep habits and problems. Response rate was 33.5%. The survey included the Munich ChronoType Questionnaire and items on circadian preference and chronic sleep problems. Mean workday sleep duration was 7:19 h (±199 min), and shorter in males (p = 0.035) and evening persons (p = 0.003). Short workday sleep duration (<6 h) was reported by 3.1% and was associated with evening preference (p = 0.001). Mean social jetlag was 0:51 h (±75 min), and longer in males (p = 0.036), younger adults (p < 0.001) and evening persons (p < 0.001). Long social jetlag (≥2 h) was reported by 11.2% and associated with younger age (p < 0.001) and evening preference (p < 0.001). Chronic sleep problems (≥3 months) were reported by 44.1%, and associated with female sex (p < 0.001) and evening preference (p = 0.002). Results underscore the importance of considering evening circadian preference as a risk factor for short workday sleep duration, long social jetlag and self-reported chronic sleep problems.
Study of Co-Deposition of Tantalum and Titanium during the Formation of Layered Composite Materials by Magnetron Sputtering
Authors: Nasakina Elena Olegovna , Sudarchikova Maria Andreevna , Demin Konstantin Yurievich , Mikhailova Alexandra Borisovna , Sergienko Konstantin Vladimirovich , Konushkin Sergey Viktorovich , Kaplan Mikhail Alexandrovich , Baikin Alexander Sergeevich , Sevostyanov Mikhail Anatolyevich , Kolmakov Alexei Georgievich
Published: January 2023

Composite materials "base–transition layer–surface metal layer (Ta/Ti)" were produced using a complex vacuum technology including magnetron sputtering. The structure (by scanning electron microscopy, Auger electron spectroscopy, X-ray diffractometry) and mechanical properties were studied. An almost linear increase in the thickness of both the surface and transition layers was observed with increasing deposition time and power; however, the growth of the surface layer slowed down with increasing power above some critical value. The transition zone with the growth of time stopped growing upon reaching about 300 nm and was formed approximately 2 times slower than the surface one (and about 3.5 times slower with power). It was noted that with equal sputtering–deposition parameters, the layer growth rates for tantalum and titanium were the same. In the sample with a Ta surface layer deposited on titanium, a strongly textured complex structure with alpha and beta Ta was observed, which is slightly related to the initial substrate structure and the underlying layer. However, even at small thicknesses of the surface layer, the co-deposition of tantalum and titanium contributes to the formation of a single tantalum phase, alpha.
A Comparative Study of Organic Dye-Sensitized Solar Cells Based on Anatase TiO2 and Amorphous Free Mixed Phase’s Anatase/Rutile P25 TiO2 Photoanodes
Authors: Al-Attafi Kadhim , Dwech Majed H. , Mezher Hamza A. , Nattestad Andrew , Kim Jung Ho
Published: January 2023

Dye-sensitized solar cells (DSCs) remain an interesting photovoltaic concept, although recent times have seen their envisioned broad-scale applications being replaced with more niche ones. Nevertheless, as a key component of DSCs, titanium(IV) oxide (TiO2) must be produced in a large volume, low cost, and highly reproducible manner. Degussa P25 remains a benchmark TiO2 product, addressing the first two of the above points very well. Post-treatment processes that may also be carried out on a large scale give some hope to addressing the reproducibility issue. This paper builds on our previous works wherein mixed-phase P25 (anatase + rutile + amorphous TiO2) was converted into an amorphous free form by selectively dissolving and recrystallizing the amorphous component. Here we investigated the performance of metal-free organic dye (D149)-based DSCs with three different TiO2 films: (1) as-received P25 (TiO2-P25), (2) amorphous-free P25 (TiO2-HP25), and (3) anatase nanoparticles obtained from Dyesol (TiO2-DSL). DSCs based on TiO2-HP25 showed comparable performance (5.8 ± 0.2% PCE) to DSCs based on the TiO2-DSL (5.8 ± 0.4% PCE) and substantially higher than for devices based on the as-obtained P25 nanoparticles (3.9 ± 0.4% PCE). The enhancement resulting from the post-processing of P25 derives from simultaneous increases in photo-current density (Jsc), open-circuit voltage (VOC), and the fill factor (FF), due to enhancing the dye-loading capability and the charge-transport efficiency (suppressing the electron recombination) as a result of the removal of amorphous barriers and associated defect states. This is in line with enhancing DSC performance based on the organometallic N719 dye we reported previously. However, the photoanode material based on abundant P25 TiO2 sensitized with high-extinction-coefficient organic D149 dye can be adopted as a cost-effective DSC as an alternative to relatively high-cost DSCs based on the commercial anatase TiO2 sensitized with organometallic N719 dye.
The Differential Evolution Algorithm for Solving the Problem of Size Selection and Location of Infectious Waste Incinerator
Authors: Srisuwandee Thitiworada , Sindhuchao Sombat , Srisuwandee Thitinon
Published: January 2023

The disposal of infectious waste remains one of the most severe medical, social, and environmental problems in almost every country. Choosing the right location and arranging the most suitable transport route is one of the main issues in managing hazardous waste. Identifying a site for the disposal of infectious waste is a complicated process because both tangible and intangible factors must be considered together, and it also depends on various rules and regulations. This research aims to solve the problem of the size selection and location of infectious waste incinerators for 109 community hospitals in the upper part of northeastern Thailand by applying a differential evolution algorithm to solve the problem with the objective of minimizing the total system cost, which consists of the cost of transporting infectious waste, the fixed costs, and the variable cost of operating the infectious waste incinerator. The developed differential evolution produces vectors that differ from the conventional differential evolution. Instead of a single set of vectors, three are created to search for the solution. In addition to solving the problem of the case study, this research conducts numerical experiments with randomly generated data to measure the performance of the differential evolution algorithm. The results show that the proposed algorithm efficiently solves the problem and can find the global optimal solution for the problem studied.
PharmKE: Knowledge Extraction Platform for Pharmaceutical Texts Using Transfer Learning
Authors: Jofche Nasi , Mishev Kostadin , Stojanov Riste , Jovanovik Milos , Zdravevski Eftim , Trajanov Dimitar
Published: January 2023

Even though named entity recognition (NER) has seen tremendous development in recent years, some domain-specific use-cases still require tagging of unique entities, which is not well handled by pre-trained models. Solutions based on enhancing pre-trained models or creating new ones are efficient, but creating reliable labeled training for them to learn on is still challenging. In this paper, we introduce PharmKE, a text analysis platform tailored to the pharmaceutical industry that uses deep learning at several stages to perform an in-depth semantic analysis of relevant publications. The proposed methodology is used to produce reliably labeled datasets leveraging cutting-edge transfer learning, which are later used to train models for specific entity labeling tasks. By building models for the well-known text-processing libraries spaCy and AllenNLP, this technique is used to find Pharmaceutical Organizations and Drugs in texts from the pharmaceutical domain. The PharmKE platform also incorporates the NER findings to resolve co-references of entities and examine the semantic linkages in each phrase, creating a foundation for further text analysis tasks, such as fact extraction and question answering. Additionally, the knowledge graph created by DBpedia Spotlight for a specific pharmaceutical text is expanded using the identified entities. The obtained results with the proposed methodology result in about a 96% F1-score on the NER tasks, which is up to 2% better than those of the fine-tuned BERT and BioBERT models developed using the same dataset. The ultimate benefits of the platform are that pharmaceutical domain specialists may more easily identify the knowledge extracted from the input texts thanks to the platform’s visualization of the model findings. Likewise, the proposed techniques can be integrated into mobile and pervasive systems to give patients more relevant and comprehensive information from scanned medication guides. Similarly, it can provide preliminary insights to patients and even medical personnel on whether a drug from a different vendor is compatible with the patient’s prescription medication.
Chlorogenic Acids and Caffeine from Coffee By-Products: A Review on Skincare Applications
Authors: Rodrigues Raquel , Oliveira Maria Beatriz Prior Pinto , Alves Rita Carneiro
Published: January 2023

Upcycling is a modern trend in the cosmetic sector, focusing on by-products reuse and waste reduction. Consumers are more aware of the origin of cosmetic products and their environmental impact, promoting the upcycling phenomenon. Converting these raw materials into products of higher quality or value contributes to the final product’s sustainability. In fact, several agri-food by-products that are typically discarded have generated great interest, due to their value-added compounds with high functionality and/or bioactivity. Coffee is well known as a cosmetic ingredient, particularly due to the presence of phenolic compounds, such as chlorogenic acids, and caffeine. Caffeine is widely used in cosmetic formulations due to its photoprotector and anti-aging properties, as well as lipolytic action in cellulitis, and hair regrowth. Chlorogenic acids are powerful antioxidants and exhibit anti-aging and photoprotector abilities. Coffee by-products, such as coffee beans, possess these bioactive compounds and other chemical characteristics that can provide functional properties in cosmetic formulations. Coffee silverskin and spent coffee grounds are high-volume by-products of the coffee industry. Their use has been explored in different cosmetic formulations demonstrating safety, stability, acceptability as well as skin improvement, thus supporting their valorization as natural and sustainable new ingredients in skincare products.
The Effect of AlN Content on the Properties of Al2O3-AlN Composite Ceramics Fabricated by Digital Light Processing
Authors: He Shaocong , Li Yehua , Zong Xiao , Wu Shanghua
Published: January 2023

In this work, Al2O3-AlN composite ceramics with high bending strength and thermal conductivity were fabricated by Digital Light Processing (DLP). The influence of AlN content on the rheological and cure behavior of Al2O3-AlN suspensions, as well as the microstructure, thermal conductivity, and bending strength of Al2O3-AlN ceramics, were systematically investigated. The result shows that the viscosity and cure ability of the suspensions were decreased with the increase of AlN content, which are beneficial to the spreading and printing accuracy of the suspensions. Besides, the bending strength of ceramics can be improved due to the residual stress by the introduction of AlN. Approaches were employed to minimize the formation of AlON in Al2O3-AlN ceramics by optimizing the amount of AlN and the sintering temperature. The thermal conductivity and bending strength of Al2O3-AlN ceramics were 31.72 ± 0.45 W/(m·K) and 572.73 ± 59.40 MPa, respectively, which are much higher than those of Al2O3 ceramics fabricated under the same condition. Finally, complex-shaped Al2O3-AlN ceramics components have been successfully fabricated by DLP, which may provide an opportunity to broaden the application of Al2O3-AlN composite ceramics in heat dissipation components.