bluuebunny/crossref_metadata_2025 huggingface dataset:
The Role and Significance of Corporate Culture in the Activities of Domestic Enterprises
Authors:   Kyiv National University of Technology and Design, Melnyk A. , Davydenko N. ,   Kyiv National University of Technology and Design
Published: April 2021

Annotation. Introduction. Corporate culture plays an important role in business environment. As the activities of the staff, their attitude towards each other influences the activity of the enterprise, managers should pay attention and introduce a corporate culture in order to increase company’s efficiency. The phrase “corporate culture” firstly was used in the nineteenth century in military terminology by a German field marshal Moltke for relevant relationships in the official environment. There are many definitions of the concept of “corporate culture”, but there is a certain difference in the interpretation of the concept with the change of years and the depth of its research. Purpose. Modern business conditions require the introduction of corporate culture, so the leaders of domestic enterprises are increasingly seeking to apply foreign experience without exploring the differences between the Ukrainian market and foreign. Therefore, the purpose of the research is to study the role of corporate culture in domestic enterprises, as well as to identify the features of the formation of corporate culture in Ukrainian enterprises. Results. As a result of the research, we were found that corporate culture as a tool of personnel management is used in only 55% of domestic enterprises. In our opinion, it is necessary to promote the introduction of corporate culture in domestic enterprises, taking into account the national mentality and social values, and for this it is necessary to develop clear tools of corporate culture, basic principles and principles, and algorithms for their implementation in enterprises. These issues need detailed consideration and will be considered by us in further research. Conclusions. Summing up everything we can say that corporate culture is not only an instrument for managing the workforce of an organization. It forms an enterprise from the inside, influencing its image and profits. The presence of corporate culture in enterprises is a competitive advantage among others in the industry. Keywords: corporate culture; competitive advantage; personnel management; labor resources; enterprise efficiency.
ANALISIS FRAUD PENTAGON TERHADAP KECURANGAN LAPORAN KEUANGAN PADA SEKTOR PERUSAHAN MANUFAKTUR YANG TERDAFTAR Di BURSA EFEK INDONESIA
Authors: Yanti Delviana Dama
Published: April 2021

ABSTRACT The purpose of this research is see the effect of pentagon fraud proxied by financial targets, nature of the industry, quality of external auditors, change of auditors, number of CEOs who frequently detect fraud in financial statements. Financial statement fraud in this study was measured using the proxies of Return on Assets, Receivables, selection of audit services at public accounting firms, changes in public accounting firms, changes in directors, and the number of CEO photos. The population in this study are manufacturing companies listed on the Indonesia Stock Exchange (BEI) in 2017-2019. This study uses a purposive sampling technique so, there are 48 financial reports from 25 manufacturing companies. The analytical method used is multiple linear regression analysis with SPSS version 20. The results of this study indicate that financial targets, nature of industry, quality of external auditors and the number of CEOs who often do not have a significant effect in the handling of fraudulent financial statements. Meanwhile, changes in auditors and changes in direction have a significant effect on fraudulent financial statements
Pengaruh Gaya Kepemimpinan dan Disiplin Kerja Terhadap Kinerja Karyawan Rumah Sakit Taman Harapan Baru Bekasi
Authors: Indriyani Ratna Indriyani , Wijayaningsih Rini , Soehardi Soehardi
Published: April 2021

Keberhasilan mencapai tujuan tergantung pada pemilihan tujuan yang akan dicapai dengan cara menggunakan sumber daya untuk mencapai tujuan organisasi sesuai dengan apa yang diharapkan. Penelitian ini ingin menguji kembali beberapa variable yang mempengaruhi kinerja karyawan. Metode penelitian ini menggunakan regresi linier berganda. Penelitian  ini  bertujuan untuk menjawab pengaruh gaya kepemimpinan dan disiplin kerja terhadap kinerja karyawan. Penelitian ini menggunakan data penyebaran kuesioner ke 105 responden. Teknik pengambilan sampel menggunakan purposive sampling dan diolah menggunakan alat statistic SPSS 22. Hasil uji parsial baik variabel gaya kepemimpinan maupun disiplin kerja berpengaruh terhadap kinerja karyawan, dan secara simultan variabel gaya kepemimpinan maupun disiplin kerja berpengaruh terhadap kinerja karyawan gaya kepemimpinan dan disiplin kerja secara bersama-sama berpengaruh terhadap kinerja karyawanKeywords: Leadership Style, Work Discipline, Employee Performance
Combustion-Derived Nanoparticles in Key Brain Target Cells and Organelles in Young Urbanites: Culprit Hidden in Plain Sight in Alzheimer’s Disease Development
Authors: González-Maciel Angélica , Reynoso-Robles Rafael , Torres-Jardón Ricardo , Mukherjee Partha S. , Calderón-Garcidueñas Lilian
Published: April 2021

Millions of children and young adults are exposed to fine particulate matter (PM2.5) and ozone, associated with Alzheimer’s disease (AD) risk. Mexico City (MC) children exhibit systemic and brain inflammation, low cerebrospinal fluid (CSF) Aβ1-42, breakdown of nasal, olfactory, alveolar-capillary, duodenal, and blood-brain barriers, volumetric and metabolic brain changes, attention and short-term memory deficits, and hallmarks of AD and Parkinson’s disease. Airborne iron-rich strongly magnetic combustion-derived nanoparticles (CDNPs) are present in young urbanites’ brains. Using transmission electron microscopy, we documented CDNPs in neurons, glia, choroid plexus, and neurovascular units of young MC residents versus matched clean air controls. CDNPs are associated with pathology in mitochondria, endoplasmic reticulum (ER), mitochondria-ER contacts (MERCs), axons,and dendrites. There is a significant difference in size and numbers between spherical CDNPs (>85%) and the angular, euhedral endogenous NPs (<15%). Spherical CDNPs (dogs 21.2 ± 7.1 nm in diameter versus humans 29.1 ± 11.2 nm, p = 0.002) are present in neurons, glia, choroid plexus, endothelium, nasal and olfactory epithelium, and in CSF at significantly higher in numbers in MC residents (p < 0.0001). Degenerated MERCs, abnormal mitochondria, and dilated ER are widespread, and CDNPs in close contact with neurofilaments, glial fibers, and chromatin are a potential source for altered microtubule dynamics, mitochondrial dysfunction, accumulation and aggregation of unfolded proteins, abnormal endosomal systems, altered insulin signaling, calcium homeostasis, apoptotic signaling, autophagy, and epigenetic changes. Highly oxidative, ubiquitous CDNPs constitute a novel path into AD pathogenesis. Exposed children and young adults need early neuroprotection and multidisciplinary prevention efforts to modify the course of AD at early stages.
Anthropogenic Iron Oxide Nanoparticles Induce Damage to Brain Microvascular Endothelial Cells Forming the Blood-Brain Barrier
Authors: Gárate-Vélez Lorena , Escudero-Lourdes Claudia , Salado-Leza Daniela , González-Sánchez Armando , Alvarado-Morales Ildemar , Bahena Daniel , Labrada-Delgado Gladis Judith , Rodríguez-López José Luis
Published: April 2021

Background: Iron nanoparticles, mainly in magnetite phase (Fe3O4 NPs), are released to the environment in areas with high traffic density and braking frequency. Fe3O4 NPs were found in postmortem human brains and are assumed to get directly into the brain through the olfactory nerve. However, these pollution-derived NPs may also translocate from the lungs to the bloodstream and then, through the blood-brain barrier (BBB), into the brain inducing oxidative and inflammatory responses that contribute to neurodegeneration. Objective: To describe the interaction and toxicity of pollution-derived Fe3O4 NPs on primary rat brain microvascular endothelial cells (rBMECs), main constituents of in vitro BBB models. Methods: Synthetic bare Fe3O4 NPs that mimic the environmental ones (miFe3O4) were synthesized by co-precipitation and characterized using complementary techniques. The rBMECs were cultured in Transwell® plates. The NPs-cell interaction was evaluated through transmission electron microscopy and standard colorimetric in vitro assays. Results: The miFe3O4 NPs, with a mean diameter of 8.45 ± 0.14 nm, presented both magnetite and maghemite phases, and showed super-paramagnetic properties. Results suggest that miFe3O4 NPs are internalized by rBMECs through endocytosis and that they are able to cross the cells monolayer. The lowest miFe3O4 NPs concentration tested induced mid cytotoxicity in terms of 1) membrane integrity (LDH release) and 2) metabolic activity (MTS transformation). Conclusion: Pollution-derived Fe3O4 NPs may interact and cross the microvascular endothelial cells forming the BBB and cause biological damage.
NLRP3 Inflammasome: A Potential Therapeutic Target in Fine Particulate Matter-Induced Neuroinflammation in Alzheimer’s Disease
Authors: Shi Jian-Quan , Wang Bian-Rong , Jiang Teng , Gao Li , Zhang Ying-Dong , Xu Jun
Published: April 2021

As one of the most harmful air pollutants, fine particulate matter (PM2.5) has been implicated as a risk factor for multiple diseases, which has generated widespread public concern. Accordingly, a growing literature links PM2.5 exposure with Alzheimer’s disease (AD). A critical gap in our understanding of the adverse effects of PM2.5 on AD is the mechanism triggered by PM2.5 that contributes to disease progression. Recent evidence has demonstrated that PM2.5 can activate NLRP3 inflammasome-mediated neuroinflammation. In this review, we highlight the novel evidence between PM2.5 exposure and AD incidence, which is collected and summarized from neuropathological, epidemiological, and neuroimaging studies to in-depth deciphering molecular mechanisms. First, neuropathological, epidemiological, and neuroimaging studies will be summarized. Then, the transport pathway for central nervous system delivery of PM2.5 will be presented. Finally, the role of NLRP3 inflammasome-mediated neuroinflammation in PM2.5 induced-effects on AD will be recapitulated.
Tobacco Smoke Exposure Impairs Brain Insulin/IGF Signaling: Potential Co-Factor Role in Neurodegeneration
Authors: Deochand Chetram , Tong Ming , Agarwal Amit R. , Cadenas Enrique , de la Monte Suzanne M.
Published: April 2021

Background: Human studies suggest tobacco smoking is a risk factor for cognitive impairment and neurodegeneration, including Alzheimer’s disease (AD). However, experimental data linking tobacco smoke exposures to underlying mediators of neurodegeneration, including impairments in brain insulin and insulin-like growth factor (IGF) signaling in AD are lacking. Objective: This study tests the hypothesis that cigarette smoke (CS) exposures can impair brain insulin/IGF signaling and alter expression of AD-associated proteins. Methods: Adult male A/J mice were exposed to air for 8 weeks (A8), CS for 4 or 8 weeks (CS4, CS8), or CS8 followed by 2 weeks recovery (CS8+R). Gene expression was measured by qRT-PCR analysis and proteins were measured by multiplex bead-based or direct binding duplex ELISAs. Results: CS exposure effects on insulin/IGF and insulin receptor substrate (IRS) proteins and phosphorylated proteins were striking compared with the mRNA. The main consequences of CS4 or CS8 exposures were to significantly reduce insulin R, IGF-1R, IRS-1, and tyrosine phosphorylated insulin R and IGF-1R proteins. Paradoxically, these effects were even greater in the CS8+R group. In addition, relative levels of S312-IRS-1, which inhibits downstream signaling, were increased in the CS4, CS8, and CS8+R groups. Correspondingly, CS and CS8+R exposures inhibited expression of proteins and phosphoproteins required for signaling through Akt, PRAS40, and/or p70S6K, increased AβPP-Aβ, and reduced ASPH protein, which is a target of insulin/IGF-1 signaling. Conclusion: Secondhand CS exposures caused molecular and biochemical abnormalities in brain that overlap with the findings in AD, and many of these effects were sustained or worsened despite short-term CS withdrawal.
Mild Cognitive Impairment and Dementia Involving Multiple Cognitive Domains in Mexican Urbanites
Authors: Calderón-Garcidueñas Lilian ,   Research Universidad del Valle de México UVM Group, Mukherjee Partha S. , Kulesza Randy J. , Torres-Jardón Ricardo , Hernández-Luna Jacqueline , Ávila-Cervantes Rodrigo , Macías-Escobedo Edgar , González-González Oscar , González-Maciel Angélica , García-Hernández Kevin , Hernández-Castillo Ariatna , Villarreal-Ríos Rodolfo
Published: April 2021

Exposures to fine particulate matter PM2.5 and ozone O3 are associated with Alzheimer’s disease (AD) risk. Mexico City residents have lifetime exposures to PM2.5 and O3 above annual USEPA standards and their brains contain high redox, combustion, and friction-derived magnetite nanoparticles. AD pathological changes with subcortical pre-tangle stages in infancy and cortical tau pre-tangles, NFT Stages I-II, and amyloid phases 1–2 are identified by the 2nd decade. Given their AD continuum, a reliable identification of cognitive impairment is of utmost importance. The Montreal Cognitive Assessment (MoCA) was administered to 517 urbanites, age 21.60 ± 5.88 years, with 13.69 ± 1.28 formal education years, in Mexican PM2.5 polluted cities. MoCA score was 23.92 ± 2.82, and 24.7% and 30.3% scored ≤24 and ≤22, respectively (MCI ≤ 24, AD ≤ 22). Cognitive deficits progressively targeted Visuospatial, Executive, Language, and Memory domains, body mass index (BMI) impacting total scores negatively (p = 0.0008), aging driving down Executive, Visuospatial, and Language index scores (p < 0.0001, 0.0037, and 0.0045), and males performing better in Executive tasks. Average age for AD MoCA scores was 22.38 ± 7.7 years. Residency in polluted cities is associated with progression of multi-domain cognitive impairment affecting 55% of Mexican seemingly healthy youth. Normal BMI ought to be a neuroprotection goal. MoCA provides guidance for further mandatory neuropsychological testing in young populations. Identifying and lowering key neurotoxicants impacting neural risk trajectories in the developing brain and monitoring cognitive performance would greatly facilitate multidisciplinary early diagnosis and prevention of AD in high risk young populations. Cognitive deficits hinder development of those representing the force moving the country in future years.
Long-Term Exposure to Ambient Air Pollution and Cognitive Function Among Hispanic/Latino Adults in San Diego, California
Authors: Ilango Sindana D. , Gonzalez Kevin , Gallo Linda , Allison Matthew A. , Cai Jianwen , Isasi Carmen R. , Hosgood H. Dean , Vasquez Priscilla M. , Zeng Donglin , Mortamais Marion , Gonzalez Hector , Benmarhnia Tarik
Published: April 2021

Background: Hispanics/Latinos in the United States are more likely to live in neighborhoods with greater exposure to air pollution and are projected to have the largest increase in dementia among race/ethnic minority groups. Objective: We examined the associations of air pollution with performance on cognitive function tests in Hispanic/Latino adults. Methods: We used data from the San Diego site of the Hispanic Community Health Study/Study of Latinos, an ongoing cohort of Hispanics/Latinos. This analysis focused on individuals ≥45 years of age who completed a neurocognitive battery examining overall mental status, verbal learning, memory, verbal fluency, and executive function (n = 2,089). Air pollution (PM2.5 and O3) before study baseline was assigned to participants’ zip code. Logistic and linear regression were used to estimate the associations of air pollution on overall mental status and domain-specific standardized test scores. Models accounted for complex survey design, demographic, and socioeconomic characteristics. Results: We found that for every 10 μg/m3 increase in PM2.5, verbal fluency worsened (β: −0.21 [95% CI: −0.68, 0.25]). For every 10 ppb increase in O3, verbal fluency and executive function worsened (β: −0.19 [95% CI: −0.34, −0.03]; β: −0.01 [95% CI: −0.01, 0.09], respectively). We did not identify any detrimental effect of pollutants on other domains. Conclusion: Although we found suggestions that air pollution may impact verbal fluency and executive function, we observed no consistent or precise evidence to suggest an adverse impact of air pollution on cognitive level among this cohort of Hispanic/Latino adults.
Air Pollution, Stress, and Allostatic Load: Linking Systemic and Central Nervous System Impacts
Authors: Thomson Errol M.
Published: April 2021

Air pollution is a risk factor for cardiovascular and respiratory morbidity and mortality. A growing literature also links exposure to diverse air pollutants (e.g., nanoparticles, particulate matter, ozone, traffic-related air pollution) with brain health, including increased incidence of neurological and psychiatric disorders such as cognitive decline, dementia (including Alzheimer’s disease), anxiety, depression, and suicide. A critical gap in our understanding of adverse impacts of pollutants on the central nervous system (CNS) is the early initiating events triggered by pollutant inhalation that contribute to disease progression. Recent experimental evidence has shown that particulate matter and ozone, two common pollutants with differing characteristics and reactivity, can activate the hypothalamic-pituitary-adrenal (HPA) axis and release glucocorticoid stress hormones (cortisol in humans, corticosterone in rodents) as part of a neuroendocrine stress response. The brain is highly sensitive to stress: stress hormones affect cognition and mental health, and chronic stress can produce profound biochemical and structural changes in the brain. Chronic activation and/or dysfunction of the HPA axis also increases the burden on physiological stress response systems, conceptualized as allostatic load, and is a common pathway implicated in many diseases. The present paper provides an overview of how systemic stress-dependent biological responses common to particulate matter and ozone may provide insight into early CNS effects of pollutants, including links with oxidative, inflammatory, and metabolic processes. Evidence of pollutant effect modification by non-chemical stressors (e.g., socioeconomic position, psychosocial, noise), age (prenatal to elderly), and sex will also be reviewed in the context of susceptibility across the lifespan.
Cerebrospinal Fluid Biomarkers in Highly Exposed PM2.5 Urbanites: The Risk of Alzheimer’s and Parkinson’s Diseases in Young Mexico City Residents
Authors: Calderón-Garcidueñas Lilian , Avila-Ramírez José , Calderón-Garcidueñas Ana , González-Heredia Tonatiuh , Acuña-Ayala Hilda , Chao Chih-kai , Thompson Charles , Ruiz-Ramos Rubén , Cortés-González Victor , Martínez-Martínez Luz , García-Pérez Mario Alberto , Reis Jacques , Mukherjee Partha S. , Torres-Jardón Ricardo , Lachmann Ingolf
Published: April 2021

Exposure to fine particulate matter (PM2.5) and ozone (O3) above US EPA standards is associated with Alzheimer’s disease (AD) risk, while Mn toxicity induces parkinsonism. Mexico City Metropolitan Area (MCMA) children have pre- and postnatal sustained and high exposures to PM2.5, O3, polycyclic aromatic hydrocarbons, and metals. Young MCMA residents exhibit frontal tau hyperphosphorylation and amyloid-β (Aβ)1–42 diffuse plaques, and aggregated and hyperphosphorylated α-synuclein in olfactory nerves and key brainstem nuclei. We measured total prion protein (TPrP), total tau (T-tau), tau phosphorylated at threonine 181 (P-Tau), Aβ1–42, α-synuclein (t-α-syn and d-α-synuclein), BDNF, insulin, leptin, and/or inflammatory mediators, in 129 normal CSF samples from MCMA and clean air controls. Aβ1–42 and BDNF concentrations were significantly lower in MCMA children versus controls (p = 0.005 and 0.02, respectively). TPrP increased with cumulative PM2.5 up to 5 μg/m3 and then decreased, regardless of cumulative value or age (R2 = 0.56). TPrP strongly correlated with T-Tau and P-Tau, while d-α-synuclein showed a significant correlation with TNFα, IL10, and IL6 in MCMA children. Total synuclein showed an increment in childhood years related to cumulated PM2.5, followed by a decrease after age 12 years R2 = 0.47), while d-α-synuclein exhibited a tendency to increase with cumulated PM2.5 (R2 = 0.30). CSF Aβ1–42, BDNF, α-synuclein, and TPrP changes are evolving in young MCMA urbanites historically showing underperformance in cognitive processes, odor identification deficits, downregulation of frontal cellular PrP, and neuropathological AD and PD hallmarks. Neuroprotection of young MCMA residents ought to be a public health priority.
Analyzing Individual-Level Secondary Data with Instrumental Variable Methods Is Useful for Studying the Effects of Air Pollution on Dementia
Authors: Bishop Kelly C. , Husain-Krautter Sehba , Ketcham Jonathan D. , Kuminoff Nicolai V. , Schimming Corbett
Published: April 2021

We hypothesize that analyzing individual-level secondary data with instrumental variable (IV) methods can advance knowledge of the long-term effects of air pollution on dementia. We discuss issues in measurement using secondary data and how IV estimation can overcome biases due to measurement error and unmeasured variables. We link air-quality data from the Environmental Protection Agency’s monitors with Medicare claims data to illustrate the use of secondary data to document associations. Additionally, we describe results from a previous study that uses an IV for pollution and finds that PM2.5’s effects on dementia are larger than non-causal associations.
Visual Design and Anthropomorphism in a Mobile Pulmonary Rehabilitation Support Intervention
Authors: Chong Cindy , Lottridge Danielle , Warren Jim , Dobson Rosie
Published: April 2021

Pulmonary rehabilitation is a behavioral intervention that can improve symptom control and quality of life for patients with chronic obstructive pulmonary disease (COPD), but access, uptake and adherence are problematic. Our team has pursued the development of a mobile phone-based intervention (mobile pulmonary rehabilitation, mPR) with iterative design and a pilot study. The mPR intervention is delivered through two technologies: text messages (SMS) and a smartphone application. Our user-centered design analysis of pilot study data led to several insights. First, patients’ replies to the SMS suggested that messages were anthropomorphised and provided social support. Second, the smartphone application could help patients by clearly visualizing the exercise program, alternative exercises, and progress to date. We demonstrate the design iterations made to meet these requirements and we present feedback obtained from experts and from four COPD patients. We discuss implications for the design of mobile pulmonary rehabilitation interventions.
Motivational Embodied Conversational Agent for Brain Injury Rehabilitation
Authors: Hocking Judith , Maeder Anthony
Published: April 2021

The design and development of a motivational embodied conversational agent for brain injury rehabilitation is discussed. Results for initial prototype design and implementation, and alpha and beta testing phases are presented. Key aspects identified during development included supporting user engagement via personalization and choice-making; integrating behaviour change principles into dialogues; addressing clinical needs of cognitive fatigue and memory loss within conversation structure; and optimizing feasibility of use in a real-life clinical setting.
Development of a Conceptual Framework for e-Health Readiness Assessment in the Context of Developing Countries
Authors: Mauco Kabelo Leonard , Scott Richard E. , Mars Maurice
Published: April 2021

Background: e-Health readiness has been described as the preparedness of healthcare institutions, communities, or individuals for the anticipated change brought by programmes related to ICT use. Assessment of e-health readiness prior to the implementation of e-health innovations can therefore facilitate the process of change for individuals and organisations to adopt e-health programmes and avoid disappointment. The literature shows that although many e-health readiness assessment frameworks and tools exist, none meet all the requirements for e-health readiness assessment in developing countries. The aim of this study was to develop an e-health readiness assessment framework applicable to developing countries. Methods: A three-step process gleaned from the e-health literature (literature review / material collection; analysis / content analysis; consolidation / conceptual framework synthesis), together with iterative and reflective processes based on prior research undertaken by this group, guided framework conceptualisation and design. Results: An evidence-based framework was developed that: incorporates the need to assess readiness for each e-health component separately; identifies government’s central role in engaging all relevant stakeholders; and the need to assess the adequacy of a country’s infrastructure and infostructure prior to e-health planning and possible implementation. Also addressed by the framework is a need for an e-health readiness assessment to be undertaken using separate tools for technical and non-technical individuals. A country’s e-Readiness is highlighted as an important indicator for e-health readiness. Conclusions: The intent of the final framework is to inform and assist policy and decision makers, and facilitate future successful implementation of e-health initiatives in the developing world.
Is There an App for That? A Scoping Review of Apps for Care Workers in the Aged Care Sector
Authors: Vandersman Priyanka , Perimal-Lewis Lua , Tieman Jennifer
Published: April 2021

Objective: To identify and review phone applications (apps) that could be used by care workers to help them plan and provide palliative care in the aged and community care setting. Methods: A scoping review. Searches were conducted in App Store and Google Play to identify apps relevant to care workers in the context of palliative and end of life care provision. Relevant apps were downloaded and evaluated. Apps allowing full access were additionally ranked against the Mobile Application Rating Scale (MARS). Information relating to the app as listed in the app stores were also extracted. Results: Of the 1,168 identified apps, only eight could be shortlisted for inclusion. The included apps were mostly English language and developed in high-income countries. The apps were primarily aimed at information provision, with limited content on palliative and end of life care. It was unclear if any of the apps were underpinned by evidence or theoretical frameworks, and none disclosed information on the app development process including involvement of end-users. The mean MARS score for full-access apps was 3.94, with the app iNotice for Carers scoring the highest score of 4.1. Conclusion: Currently available care worker apps appear to have limited functionality and scope in relation to palliative and end of life care. There is opportunity for a co-designed care-worker app development endeavour that is underpinned by robust evidence, and has high-level usability and relevance.
From collection to integration: Non-parametric Statistical Matching between primary and secondary farm data
Authors: D’Alberto Riccardo , Raggi Meri
Published: April 2021

Big Data and the ‘Internet of Things’ are transforming the processes of data collection, storage and use. The relationship between data collected first hand (primary data) and data collected by someone else (secondary data) is becoming more fluid. New possibilities for data collection are envisaged. Data integration is emerging as a reliable strategy to overcome data shortage and other challenges such as data coverage, quality, time dis-alignment and representativeness. When we have two (or more) data sources where the units are not (at least partially) overlapping and/or the units’ unique identifiers are unavailable, the different information collected can be integrated by using Micro Statistical Matching (MiSM). MiSM has been used in the social sciences, politics and economics, but there are very few applications that use agricultural and farm data. We present an example of MiSM data integration between primary and secondary farm data on agricultural holdings in the Emilia-Romagna region (Italy). The novelty of the work lies in the fact that integration is carried out with non-parametric MiSM, which is compared to predictive mean matching and Bayesian linear regression. Moreover, the matching validity is assessed with a new strategy. The main issues addressed, the lessons learned and the use in a research field characterised by critical data shortage are discussed.
Aplicación social del impuesto y del ahorro
Authors: Redacción Consejo de
Published: April 2021

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Creep Grazing for Suckling Calves - A Pasture Management Practice
Authors: Chambliss Carrol G. , Mayo Doug E.
Published: April 2021

Selling additional pounds of calf is a desirable objective in any beef cattle enterprise. One way to do this in a cow-calf operation is through creep grazing. Creep grazing puts additional pounds on nursing calves. When weaned, creep grazed calves may weigh 30 to 50 pounds more per calf than those calves that have not had creep grazing available to them. This document is SS-AGR-211, one of a series of the Agronomy Department, Florida Cooperative Extension Service, Institute of Food and Agricultural Sciences, University of Florida. Publication date February 2004.

SS-AGR-211/AG193: Creep Grazing for Suckling Calves?A Pasture Management Practice (ufl.edu)
Cuban Agriculture Before 1959: The Political and Economic Situations
Authors: Alvarez José
Published: April 2021

Cubans fought for their independence from Spain for most of the nineteenth century. Since most of the armed struggles took place in the countryside and the majority of the fighters were rural inhabitants, the agriarian issue was deeply embedded in the republic inaugurated on May 20, 1902. What was the rural reality during the 57 years between 1902 and 1959? Answers appear at both extremes of the political spectrum, exposed and espoused by supporters and detractors of the current Cuban regime. This fact sheet intends to address these conflicting viewpoints by analyzing the available data on pre-1959 rural Cuba. This is EDIS document FE479, a publication of the Department of Food and Resource Economics, Florida Cooperative Extension Service, UF/IFAS, University of Florida, Gainesville, FL. Published July 2004.

FE479/FE479: Cuban Agriculture Before 1959: The Political and Economic Situations (ufl.edu)
ACOPIO: Cuba's State Procurement and Distribution Agency
Authors: Alvarez José
Published: April 2021

One of the reasons for the food scarcity in Cuba, especially that related to perishable and non-perishable agricultural product wastes, falls on Acopio, the state collection and distribution agency. This fact sheet summarizes the role of this state agency since the early days of the Cuban revolution along with its inefficiencies and reorganizations. This is EDIS document FE484, a publication of the Department of Food and Resource Economics, Florida Cooperative Extension Service, UF/IFAS, University of Florida, Gainesville, FL. Published July 2004.

FE484/FE484: ACOPIO: Cuba's State Procurement and Distribution Agency (ufl.edu)
Chronology of Cuban Reform Policies with Emphasis on Agriculture, 1993-1995
Authors: Alvarez José
Published: April 2021

The reports included in this series intend to address the increasing level of interest in the Cuban market for food and agricultural products among U.S. firms and to assist them in becoming more familiar with that market. The complete list of documents in this series can be found by conducting a topical search for “Cuba” at http://edis.ifas.ufl.edu, or under "Additional Information" at the end of this document. This is EDIS document FE486, a publication of the Department of Food and Resource Economics, Florida Cooperative Extension Service, UF/IFAS, University of Florida, Gainesville, FL. Published July 2004.

FE486/FE486: Chronology of Cuban Reform Policies with Emphasis on Agriculture, 1993?1995 (ufl.edu)
Cuba's Agricultural Markets
Authors: Alvarez José
Published: April 2021

The reports included in this series intend to address the increasing level of interest in the Cuban market for food and agricultural products among U.S. firms and to assist them in becoming more familiar with that market. The complete list of documents in this series can be found by conducting a topical search for “Cuba” at http://edis.ifas.ufl.edu, or under "Additional Information" at the end of this document. This is EDIS document FE488, a publication of the Department of Food and Resource Economics, Florida Cooperative Extension Service, UF/IFAS, University of Florida, Gainesville, FL. Published July 2004.

FE488/FE488: Cuba's Agricultural Markets (ufl.edu)
Acer japonicum
Authors: Gilman Edward F.
Published: April 2021

Full-moon maple is a small, deciduous tree that reaches 10 to 15 feet in both height and width, creating a smooth, rounded canopy (Figure 1). It fits well into the oriental garden due to its exotic silhouette. The cultivar 'Acontifolium' is exceptionally cold hardy, having survived temperatures of 25°F below zero. The deeply divided, soft green leaves have 9 to 11 lobes and are delicately displayed on thin, drooping branches. The cultivar 'Vitifolium's' leaves are less divided, providing a coarse texture in the landscape. Leaves take on a beautiful yellow to red coloration in the fall before dropping, making this small, dense plant really stand out in the landscape. Fall color has been described as exceptional. The hanging clusters of showy, purple/red flowers appear in late spring and are followed by the production of winged seeds. The full-moon maple's flowers stand out among the maples. This document is FPS 007, one of a series of the Environmental Horticulture Department, Florida Cooperative Extension Service, Institute of Food and Agricultural Sciences, University of Florida. Original publication date October 1, 1999. Revised October 1, 2004. Reviewed October, 2004. 

FPS007/FP007: Acer japonicum Fullmoon Maple (ufl.edu)
Achillea spp.
Authors: Gilman Edward F. , DelValle Terry
Published: April 2021

Achillea species are 18- to 36-inch-tall perennials that bear masses of flowers throughout the summer (Figure 1). The 60 to 100 species of yarrow are ancient, spreading, semi-evergreen herbs that are long lived. The aromatic, finely divided leaves are alternate or in basal rosettes. The leaf margins range from simple and toothed to pinnately dissected. However, most of these species have attractive feathery or fern-like foliage. The flowers may be single or double and come in shades of pink, yellow and white; flower heads are mostly in fine-textured corymbs. This document is Fact Sheet FPS-11, one of a series of the Environmental Horticulture Department, Florida Cooperative Extension Service, Institute of Food and Agricultural Sciences, University of Florida. Publication date: October 1999; reviewed October 2003. 

FPS 11/FP011: Achillea spp.Yarrow (ufl.edu)
Acrostichum daneifolium
Authors: Gilman Edward F.
Published: April 2021

This beautiful fern (Figure 1) that is native to Florida grows larger than many other ferns, becoming 4 to 8 feet tall. The 3- to 6-foot-long, pinnately divided fronds emerge from the ground to form a beautifully textured, open form. The plant changes very little throughout the year, but provides a continual green mass of beautiful foliage. This document is Fact Sheet FPS-12, one of a series of the Environmental Horticulture Department, Florida Cooperative Extension Service, Institute of Food and Agricultural Sciences, University of Florida. Publication date: October 1999; reviewed October 2003. 

FPS12/FP012: Acrostichum daneifolium Leather Fern (ufl.edu)
Vida Saludable para Personas de Edad: ¡Use Sus Medicinas Con Prudencia!
Authors: Wittkowsky Paulina
Published: April 2021

Las medicinas nos ayudan a sentirnos mejor. Pero también pueden hacernos daño si no las usamos correctamente. Para usar sus medicinas con prudencia, tenga en mente los siguientes consejos.

This document, FCS8594-Span, is one in a series of the Department of Family, Youth and Community Sciences, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, FL 32611. Publication date: March 2004.

FCS8594-Span/FY668: Vida Saludable: ¡Use sus medicinas de una manera segura! (ufl.edu)
Queensland Fruit Fly, Bactrocera tryoni (Froggatt) (Insecta: Diptera: Tephritidae)
Authors: Weems, Jr. Howard V. , Fasulo Thomas R.
Published: April 2021

The Queensland fruit fly, Bactrocera tryoni (Froggatt), occurs in climates ranging from temperate to tropical. Within its range, it is one of the most important pests with which pome and stone fruit growers have to contend, and at times it has been a very destructive pest of citrus. Bactrocera tryoni appears to be almost as destructive to fruit production in its Australian range as the oriental fruit fly, Bactrocera dorsalis Hendel, is in countries where it appears. A heavy outbreak of B. tryoni in New South Wales during 1940-41 resulted in the rejection of 5 to 25% of citrus at harvest. It is not established in the United States, but the extensive damage caused by the larvae of this fly in areas similar to Florida where it has become established indicates that this species could become a serious pest of pome and stone fruit crops, and possibly of citrus, if it were to become established in Florida. This document is EENY-259 (originally published as DPI Entomology Circular 34), one of a series of Featured Creatures from the Entomology and Nematology Department, Florida Cooperative Extension Service, Institute of Food and Agricultural Sciences, University of Florida. Published: January 2002. 

EENY259/IN540: Queensland Fruit Fly, Bactrocera tryoni (Froggatt) (Insecta: Diptera: Tephritidae) (ufl.edu)
Fruit Fly, Anastrepha edentata Stone (Insecta: Diptera: Tephritidae)
Authors: Weems, Jr. Howard V.
Published: April 2021

Anastrepha edentata Stone has been collected in the Florida keys in every month of the year, but its host plants still are unknown. It is one of six species of fruit flies of the genus Anastrepha which occur in Florida or which have been established in Florida at some time. According to Division of Plant Industry records, it has not been found in Florida since 1936. There is a possibility that this species has not survived in Florida. It is not considered to be of economic importance anywhere within its range. This document is EENY-264 (originally published as DPI Entomology Circular 76), one of a series of Featured Creatures from the Entomology and Nematology Department, Florida Cooperative Extension Service, Institute of Food and Agricultural Sciences, University of Florida. Published: January 2002. 

https://edis.ifas.ufl.edu/in543
Striped Blister Beetle, Epicauta vittata (Fabricius) (Coleoptera: Meloidae)
Authors: Capinera John L.
Published: April 2021

The striped blister beetle, Epicauta vittata (Fabricius), is a native species. It has been collected from all eastern states west to, and including, South Dakota, Nebraska, Kansas and Oklahoma. In Canada it is known from Quebec and Ontario. Populations from the southeastern coastal plain including Florida, southern Georgia and eastern South Carolina differ in appearance from beetles found elsewhere and are called the 'lemniscate race,' but interbreed successfully with normal beetles. This document is EENY-280, one of a series of Featured Creatures from the Entomology and Nematology Department, Florida Cooperative Extension Service, Institute of Food and Agricultural Sciences, University of Florida. Published: January 2003.

EENY280/IN556: Striped Blister Beetle, Epicauta vittata (Fabricius) (Coleoptera: Meloidae) (ufl.edu)
Secure Pesticide Storage: Security and Safety-promoting Features of Pesticide Storage Facilities
Authors: Dean Thomas W.
Published: April 2021

This document describes nine features that specifically promote pesticide storage facility security and safety. This document is Fact Sheet PI-32, part of a series from the Pesticide Information Office, Food Science and Human Nutrition Department, Florida Cooperative Extension Service, Institute of Food and Agricultural Sciences, University of Florida. Published: April 2004. Revised: November 2004.

https://edis.ifas.ufl.edu/pi067
A Series on Diseases in the Florida Vegetable Garden: PEPPER
Authors: Pernezny Ken , Momol Tim
Published: April 2021

The majority of plant health problems categorized as plant diseases are caused by microorganisms. As the name implies, these are extremely tiny disease agents that ordinarily require a microscope to be seen. The very minute size of these disease-causing pathogens accounts for the mystery that often surrounds their presence and impact in the garden. The pathogenic microorganisms that attack garden vegetables, including pepper, can be classified into three major groups: fungi, bacteria, and viruses. This document is Fact Sheet PP-201, one of a series of the Plant Pathology Department, Florida Cooperative Extension Services, Institute of Food and Agricultural Sciences, University of Florida. Published July 2004.

https://edis.ifas.ufl.edu/pp122
Setting Transparent Expectations for Successful Group Work
Authors: Suarez Cecilia E. , Shellhouse Jarred A.
Published: April 2021

Regardless of workspace or class setting, group work has gotten a reputation for being less than pleasant. However, when individuals have the opportunity to prepare for group work via understanding their personal strengths, expectations, and perspectives, the not-so-popular group work can often turn into pleasant, productive, and collaborative engagement. Because group dynamics shift and vary from group to group, there is a constant learning opportunity to understand how to work in groups successfully. This new 2-page publication of the UF/IFAS Department of Agricultural Education and Communication will identify simple yet effective strategies that can serve as foundational building blocks whenever preparing oneself or others for group work. Written by Cecilia E. Suarez and Jarred A. Shellhouse.https://edis.ifas.ufl.edu/wc389
Pengaturan Memperoleh Kembali Status Warga Negara Indonesia Bagi ISIS Eks WNI Ditinjau Dari Peraturan Pemerintah Nomor 2 Tahun 2007 dan Konsep Maslahah Mursalah
Authors: Bari Saiful
Published: April 2021

This research is motivated by the loss of Indonesian citizenship status experienced by Indonesian citizens who are members of ISIS combatants. This is in line with of Article 23 letter e in Law No. 12 of 2006. The purpose of this study is to analyze the arrangements to regain the status of Indonesian citizens. This type of research is normative law. This study uses a law approach and the concept of the problem maslahah. The main material data of this study are from perimer legal material and secondary legal material. The results of this study conclude that first, in the perspective of the Citizenship Law and its implementing regulations, ex-ISIS former citizens are not eligible to regain Indonesian citizenship status as regulated by Article 9 of Law No. 12 of 2006 and Article 2 to Article 12 of PP No. 2 of 2007. Second, in the perspective of the problem maslahah, the Citizenship Act and its implementing regulations do not conflict with the sources and the propositions of Islamic law. Therefore, maintaining the sovereignty of the Unitary State of the Republic of Indonesia and the interests of the people by not giving them RI citizenship status is a beneficial act.
Ion Mihai Pacepa szökése és hatása a román hírszerző szolgálatokra
Authors: Bandi István
Published: April 2021

Az 1989-et megelőző időszak román hírszerzése második számú vezetőjének szökését napjainkig nagy érdeklődés övezi. Négy évtized távlatából a levéltári források egy friss olvasatát adják Pacepa átállásának, és ezen túl bepillantást engednek a román hírszerzés kulisszáiba is. Jelen tanulmányban Ion Mihai Pacepa könyvei nyomán kialakult mítoszt mellőzve egy ellenőrizhető forgatókönyvet állítottunk fel a nyugati táborba való átlépéséről és annak következményeiről.
Diversity and Functions of Type II Topoisomerases
Authors: Sutormin Dmitry A. , Galivondzhyan Alina Kh. , Polkhovskiy Alexander V. , Kamalyan Sofia O. , Severinov Konstantin V. , Dubiley Svetlana A.
Published: April 2021

The DNA double helix provides a simple and elegant way to store and copy genetic information. However, the processes requiring the DNA helix strands separation, such as transcription and replication, induce a topological side-effect supercoiling of the molecule. Topoisomerases comprise a specific group of enzymes that disentangle the topological challenges associated with DNA supercoiling. They relax DNA supercoils and resolve catenanes and knots. Here, we review the catalytic cycles, evolution, diversity, and functional roles of type II topoisomerases in organisms from all domains of life, as well as viruses and other mobile genetic elements.
Mechanisms of Action of the PGLYRP1/Tag7 Protein in Innate and Acquired Immunity
Authors: Yashin Denis V. , Saschenko Lidia P. , Georgiev George P.
Published: April 2021

One of the promising fields of modern molecular biology is the search for new proteins that regulate the various stages of the immune response and the investigation of the molecular mechanisms of action of these proteins. Such proteins include the multifunctional protein PGLYRP1/Tag7, belonging to the PGRP-S protein family, whose gene was discovered in mice at the Institute of Gene Biology, Russian Academy of Sciences, in 1996. PGLYRP1/Tag7 is classified as a protein of innate immunity; however, it can also participate in the regulation of acquired immunity mechanisms. In this paper, we consider the involvement of PGLYRP1/Tag7 in the triggering of antimicrobial defense mechanisms and formation of subsets of cytotoxic lymphocytes that kill tumor cells. The paper emphasizes that the multifaceted functional activity of Tag7 in the immune response has to do with its ability to interact with various proteins to form stable protein complexes. Hsp70-associated Tag7 can induce the death of tumor cells carrying the TNFR1 receptor. Tag7, associated with the Mts1 (S100A4) protein, can stimulate the migration of innate and adaptive immune cytotoxic lymphocytes to a lesion site. Involvement of Tag7 in the regulation of immunological processes suggests that it may be considered as a promising agent in cancer therapy. These properties of Tag7 were used to develop autologous vaccines that have passed the first and second phases of clinical trials in patients with end-stage melanoma and renal cancer. The C-terminal peptide of Tag7, isolated by limited proteolysis, was shown to protect the cartilage and bone tissue of the ankle joint in mice with induced autoimmune arthritis and may be a promising drug for suppressing the development of inflammatory processes.
CTCF As an Example of DNA-Binding Transcription Factors Containing Clusters of C2H2-Type Zinc Fingers
Authors: Maksimenko Oksana G. , Fursenko Dariya V. , Belova Elena V. , Georgiev Pavel G.
Published: April 2021

In mammals, most of the boundaries of topologically associating domains and all well-studied insulators are rich in binding sites for the CTCF protein. According to existing experimental data, CTCF is a key factor in the organization of the architecture of mammalian chromosomes. A characteristic feature of the CTCF is that the central part of the protein contains a cluster consisting of eleven domains of C2H2-type zinc fingers, five of which specifically bind to a long DNA sequence conserved in most animals. The class of transcription factors that carry a cluster of C2H2-type zinc fingers consisting of five or more domains (C2H2 proteins) is widely represented in all groups of animals. The functions of most C2H2 proteins still remain unknown. This review presents data on the structure and possible functions of these proteins, using the example of the vertebrate CTCF protein and several well- characterized C2H2 proteins in Drosophila and mammals.