bluuebunny/crossref_metadata_2025 huggingface dataset:
SMAP: a streamlined methylation analysis pipeline for bisulfite sequencing
Authors: Gao Shengjie , Zou Dan , Mao Likai , Zhou Quan , Jia Wenlong , Huang Yi , Zhao Shancen , Chen Gang , Wu Song , Li Dongdong , Xia Fei , Chen Huafeng , Chen Maoshan , Ørntoft Torben F , Bolund Lars , Sørensen Karina D
Published: June 2015

Background

DNA methylation has important roles in the regulation of gene expression and cellular specification. Reduced representation bisulfite sequencing (RRBS) has prevailed in methylation studies due to its cost-effectiveness and single-base resolution. The rapid accumulation of RRBS data demands well designed analytical tools.

Findings

To streamline the data processing of DNA methylation from multiple RRBS samples, we present a flexible pipeline named SMAP, whose features include: (i) handling of single—and/or paired-end diverse bisulfite sequencing data with reduced false-positive rates in differentially methylated regions; (ii) detection of allele-specific methylation events with improved algorithms; (iii) a built-in pipeline for detection of novel single nucleotide polymorphisms (SNPs); (iv) support of multiple user-defined restriction enzymes; (v) conduction of all methylation analyses in a single-step operation when well configured.

Conclusions

Simulation and experimental data validated the high accuracy of SMAP for SNP detection and methylation identification. Most analyses required in methylation studies (such as estimation of methylation levels, differentially methylated cytosine groups, and allele-specific methylation regions) can be executed readily with SMAP. All raw data from diverse samples could be processed in parallel and ‘packetized' streams. A simple user guide to the methylation applications is also provided.
Safety of Infusing Ipilimumab Over 30 Minutes
Authors: Momtaz Parisa , Park Vivian , Panageas Katherine S. , Postow Michael A. , Callahan Margaret , Wolchok Jedd D. , Chapman Paul B.
Published: June 2015

Purpose

The approved dose of ipilimumab is 3 mg/kg infused over 90 minutes; however, in clinical trials, 10 mg/kg has also been infused over 90 minutes. At this higher dose, patients receive 3 mg/kg within the first 27 minutes of treatment. We sought to determine whether the standard dose of 3 mg/kg could be safely infused over 30 minutes.

Methods

We reviewed retrospectively the incidence of infusion-related reactions (IRRs) to ipilimumab at our institution in patients receiving doses of either 3 or 10 mg/kg infused over 90 minutes. Our findings led to a change in institutional guidelines for ipilimumab infusion time from 90 minutes to 30 minutes. We reviewed the first 14 months of our prospective experience using a 30-minute infusion of ipilimumab.

Results

Between April 1, 2008, and June 30, 2013, 595 patients received 2,507 doses of ipilimumab infused at either 3 mg/kg (n = 457) or 10 mg/kg (n = 138) over 90 minutes. Although the 10 mg/kg group had a higher incidence of IRRs (4.3%) than the 3 mg/kg group (2.2%), this difference was not statistically significant (P = .22). In 120 patients treated prospectively with ipilimumab 3 mg/kg infused over 30 minutes, seven patients (5.8%) had an IRR (P = .06 compared with 90-minute infusions). All IRRs occurred at dose 2; six were grade 2, and one was grade 3. All seven patients received subsequent doses of ipilimumab safely, the majority with premedication.

Conclusion

Ipilimumab at 3 mg/kg can be infused safely over 30 minutes with an acceptably low incidence of IRRs. After an IRR, patients can safely receive additional doses of ipilimumab with premedication.
Encouraging Competition and Cooperation: The Affordable Care Act's Contradiction?
Authors: Grogan Colleen M.
Published: June 2015

This introductory essay to JHPPL's special issue on accountable care organizations (ACOs) presents the broader themes addressed in the issue, including (1) a central tension between cooperation versus competition in health care markets with regard to how to bring about improved quality, lower costs, and better access; (2) US regulatory policy — whether it will be able to achieve the appropriate balance in health care markets under which ACOs could realize expected outcomes; and (3) ACO realities — whether ACOs will be able to overcome or further embed existing inequities in US health care markets.
Growth of Accountable Care Organizations in California: Number, Characteristics, and State Regulation
Authors: Fulton Brent D. , Pegany Vishaal , Keolanui Beth , Scheffler Richard M.
Published: June 2015

Accountable care organizations (ACOs) result in physician organizations' and hospitals' receiving risk-based payments tied to costs, health care quality, and patient outcomes. This article (1) describes California ACOs within Medicare, the commercial market, and Medi-Cal and the safety net; (2) discusses how ACOs are regulated by the California Department of Managed Health Care and the California Department of Insurance; and (3) analyzes the increase of ACOs in California using data from Cattaneo and Stroud. While ACOs in California are well established within Medicare and the commercial market, they are still emerging within Medi-Cal and the safety net. Notwithstanding, the state has not enacted a law or issued a regulation specific to ACOs; they are regulated under existing statutes and regulations. From August 2012 to February 2014, the number of lives covered by ACOs increased from 514,100 to 915,285, representing 2.4 percent of California's population, including 10.6 percent of California's Medicare fee-for-service beneficiaries and 2.3 percent of California's commercially insured lives. By emphasizing health care quality and patient outcomes, ACOs have the potential to build and improve on California's delegated model. If recent trends continue, ACOs will have a greater influence on health care delivery and financial risk sharing in California.
LIF signaling in stem cells and development
Authors: Onishi Kento , Zandstra Peter W.
Published: June 2015

Leukemia inhibitory factor (LIF) is a member of the interleukin-6 (IL-6) cytokine family. All members of this family activate signal transducer and activator of transcription 3 (STAT3), a transcription factor that influences stem and progenitor cell identity, proliferation and cytoprotection. The role of LIF in development was first identified when LIF was demonstrated to support the propagation of mouse embryonic stem cells. Subsequent studies of mice deficient for components of the LIF pathway have revealed important roles for LIF signaling during development and homeostasis. Here and in the accompanying poster, we provide a broad overview of JAK-STAT signaling during development, with a specific focus on LIF-mediated JAK-STAT3 activation.
FGF8 coordinates tissue elongation and cell epithelialization during early kidney tubulogenesis
Authors: Atsuta Yuji , Takahashi Yoshiko
Published: June 2015

When a tubular structure forms during early embryogenesis, tubular elongation and lumen formation (epithelialization) proceed simultaneously in a spatiotemporally coordinated manner. We here demonstrate, using the Wolffian duct (WD) of early chicken embryos, that this coordination is regulated by the expression of FGF8, which shifts posteriorly during body axis elongation. FGF8 acts as a chemoattractant on the leader cells of the elongating WD and prevents them from epithelialization, whereas static (‘rear’) cells that receive progressively less FGF8 undergo epithelialization to form a lumen. Thus, FGF8 acts as a binary switch that distinguishes tubular elongation from lumen formation. The posteriorly shifting FGF8 is also known to regulate somite segmentation, suggesting that multiple types of tissue morphogenesis are coordinately regulated by macroscopic changes in body growth.
Vertical Contracting with Informational Opportunism
Authors: Dequiedt Vianney , Martimort David
Published: June 2015

We consider vertical contracting arrangements between a manufacturer and a retailing network when retailers have private information and the organization is run through bilateral contracts. We highlight a new form of informational opportunism arising when the manufacturer manipulates information learned separately in each relationship. We characterize the set of allocations robust to such opportunism by means of simple ex post incentive compatibility constraints. Those constraints limit the manufacturer's ability to use yardstick competition among retailers. They simplify contracts and restore a rent/efficiency trade-off even with correlated information. We show that sell-out contracts are optimal under a wide range of circumstances. (JEL D21, D86, L14, L60, L81)
Banking, Liquidity, and Bank Runs in an Infinite Horizon Economy
Authors: Gertler Mark , Kiyotaki Nobuhiro
Published: June 2015

We develop an infinite horizon macroeconomic model of banking that allows for liquidity mismatch and bank runs. Whether a bank run equilibrium exists depends on bank balance sheets and an endogenous liquidation price for bank assets. While in normal times a bank run equilibrium may not exist, the possibility can arise in recessions. A run leads to a significant contraction in intermediation and aggregate economic activity. Anticipations of a run have harmful effects on the economy even if the run does not occur. We illustrate how the model can shed light on some key aspects of the recent financial crisis. (JEL E23, E32, E44, G01, G21, G33)
Financial Entanglement: A Theory of Incomplete Integration, Leverage, Crashes, and Contagion
Authors: Gârleanu Nicolae , Panageas Stavros , Yu Jianfeng
Published: June 2015

We propose a unified model of limited market integration, asset-price determination, leveraging, and contagion. Investors and firms are located on a circle, and access to markets involves participation costs that increase with distance. Due to a complementarity between participation and leverage decisions, the equilibrium may exhibit diverse leverage and participation choices across investors, although investors are ex ante identical. Small changes in market-access costs can cause a change in the type of equilibrium, leading to discontinuous price changes, deleveraging, and portfolio-flow reversals. Moreover, the market is subject to contagion—an adverse shock to investors in some locations affects prices everywhere. (JEL D83, G11, G12, G32, G35)
Acquisitions, Productivity, and Profitability: Evidence from the Japanese Cotton Spinning Industry
Authors: Braguinsky Serguey , Ohyama Atsushi , Okazaki Tetsuji , Syverson Chad
Published: June 2015

We explore how changes in ownership affect the productivity and profitability of producers. Using detailed data from the Japanese cotton spinning industry at the turn of the last century, we find that acquired firms' production facilities were not on average less physically productive than the plants of the acquiring firms before acquisition. They were much less profitable, however, due to higher inventory levels and lower capacity utilization—differences that reflected problems in managing the uncertainties of demand. After acquisitions, less profitable acquired plants saw drops in inventories and gains in capacity utilization that raised both their productivity and profitability levels. (JEL D24, G32, G34, L11, L25, L66, N65)
Determination of density of temperature coefficients for the Earth’s atmosphere muons
Authors: Кузьменко Василий , Kuzmenko Vasiliy , Янчуковский Валерий , Yanchukovsky Valery
Published: June 2015

When studying variations of cosmic ray intensity, by the use of muon telescopes located deep in the atmosphere it is necessary to take into account changes in atmospheric parameters, mainly pressure and temperature. The density distribution of temperature coefficients of the atmosphere muon intensity needs to be estimated from observations. To this purpose, the method of principal components regression and meth-ods of projection to latent structures (PLS-1 and PLS-2). We used data of continuous recording of muons, as well as Novosibirsk 2004–2010 aerological data. As shown by comparing results, PLS-2 method allows us to esti-mate the density distribution of muon intensity temperature coefficients with minimal errors.
Agricultural Insurance: Problems of Legal Regulation and Means of Possible Solution
Authors: Семенова  , Semenova Nataliya
Published: June 2015

The article considers issues of legal regulation of agricultural insurance involving state support. It analyses the

problems of this sector and reasons for agricultural manufacturers’ low interest in such insurance. The article proposes

means to enhance the legislation of agricultural insurance.
Similarities and differences between regular variations of F2-layer parameters of polar and midlatitude ionosphere in East Siberian sector
Authors: Ратовский Константин , Ratovsky Konstantin , Ойнац Алексей , Oinats Aleksey , Медведев Андрей , Medvedev Andrey
Published: June 2015

Analysis of similarities and differences between the polar and midlatitude ionosphere in the East Siberian sector was performed with local ionosphere models. The local models were constructed using 6-year (December 2002 — December 2008) continuous measurements made with ionosondes located in Norilsk (69.4 N, 88.1 E) and Irkutsk (52.3 N, 104.3 E). The models describe variations of regular ionospheric parameters in terms of diurnal and seasonal variations under low solar activity and their changes with increasing solar activity. The paper discusses regular variations of the main F2-layer parameters: the electron density maximum (NmF2) and the peak height (hmF2). Special attention has been given to the manifestation of such phenomena as the winter anomaly, semiannual anomaly, summer evening anomaly, and formation of the winter night peak at the polar and mid-latitude stations. The specific diurnal and seasonal behavior of hmF2 in Norilsk is explained by the maximum magnetic inclination and the lowest geomagnetic latitude compared to other polar stations located at the same geographic latitude.
Linear evolution of the vortex induced by localized temperature disturbance in stratified shear flow
Authors: Шухман Илья , Shukhman Ilia Grigorevich , Вайс Тевнер Шошана , Weiss Tewner Shoshana , Коэн Яаков , Cohen Jacob
Published: June 2015

We study the combined effect of the shear flow velocity and its (stable) vertical stratification on the evolution of the three-dimensionally localized vortical disturbance induced by the initial temperature perturbation embedded at the initial time into a local region of the flow. Small geometric scales of perturbations compared to the characteristic scales of velocity and temperature variation of the background flow allow to consider vertical gradients of the horizontal velocity and temperature to be not dependent on the coordinates. Assuming a disturbance sufficiently weak, we use linear theory to calculate fields of vorticity and temperature. The problem is solved analytically using a three-dimensional Fourier transform of the basic set of equations and further transition to a Lagrange variables in the Fourier space. It is shown that the growth of the intensity of the vortex (a measure of which are enstrophy and circulation) is obliged to both stratification and shear. However, the character of this growth (monotonous or oscillating) depends on what of two factors dominates. In the case where the dissipation effects are negligible, enstrophy grows indefinitely (in the framework of the linear theory), but dissipative factors (viscosity and thermal diffusivity) modified this growth and make it only transient, so that eventually the perturbation decays. Perturbation domain stretches along the direction of flow, but its vertical and horizontal movement as a whole in the framework of the linear theory doesn’t occur, since it is the nonlinear effect. Nonlinear evolution of the vortex induced by temperature disturbance is considered in a separate paper.
Reflections on educational policy reforms and music education
Authors: Bernal Celia Ruiz
Published: June 2015

In this paper I reflect on some topics discussed in this monograph about educational policy reforms and their impact on music education. Thus, I cope with issues related to the place music education has as part of the general curriculum (kindergarten, Primary and Secondary Education) and the specialised music education system (conservatoires and schools of music).

Major ideas provided could be summarised in the vindication of a value-based humanistic education as major contribution of the school music. I also claim for a reconsideration of the place the higher music education system takes place in the Spanish educational system. Finally, I suggest a redefinition of music teachers understand as music education.
A Comparative Invitro Study Investigating the Dentinal Changes Caused by Commercially Available Desensitizing Toothpastes and Laser - Original Research Article
Authors: Mohan Rudra , Jothi V. , Ballal Vasudev
Published: June 2015

Aim: The aim of this study was to compare the level of dentinal tubule blocking and mineralization achieved by the use of two commercially available dentifrices (Vantej® and Colgate® sensitive Pro-relief) with or without the use of laser for the management of dentinal hypersensitivity.
Method: Sixty extracted human molar teeth were used for this study. The teeth were sectioned into dentin discs of 2-4mm thickness. These specimens were then randomly divided into 6 groups and were treated with Vantej® tooth paste, Colgate Sensitive Pro-relief® tooth paste, Helium- Neon (He-Ne) laser, combination of He-Ne laser and Vantej® tooth paste and a combination of He-Ne laser and Colgate Sensitive Prorelief® tooth paste. The specimens were then analyzed under scanning electron microscope (SEM) for the evaluation of dentinal tubular blocking. The elemental analysis of the tubular content was evaluated using Energy Dispersive Xray Spectroscopy (EDX).
Results: The SEM analysis showed significant difference in the mean percentage scores within the individual groups. The Laser with Colgate Sensitive Prorelief® tooth paste group showed complete blocking of the dentinal tubules which was statistically significant (P<0.001), similar results were also observed with the Pro-relief® alone toothpaste group. The Vantej® tooth paste group also exhibited significant tubular blocking. The Laser alone group and combination of laser and Vantej® tooth paste group showed only partial tubular blocking. EDX analysis of the experimental groups revealed peaks of the elemental contents found in the experimental specimens.
Conclusion: The data obtained from this study demonstrated that the Colgate sensitive Pro-relief® toothpaste alone and /or when used in combination with laser therapy was found to most effective in the blocking of dentinal tubules.
Effect of Transition Metal Addition in the Bioactivity of Borate Bioglass Dental Materials
Authors: Kamal H. , Abdelghany A.M.
Published: June 2015

Objectives: The basic structure and some physical properties of a bioactive borate glasses doped with transition metals were prepared and investigated with the same molar composition as 45S5 glass but with all the silicon dioxide (SiO2) replaced by boron trioxide (B2O3).
Methods: The biodegradability was explored and estimated by soaking the samples into simulated body fluid (SBF) at 37ºC for 30 days. The pH changes of solution were measured during the soaking periods in order to explore the ionic change processes. The structural changes in the crystalline phases obtained in the glass matrix before and after immersion in SBF were recognized by means of X-ray diffraction (XRD) and Fourier transform infrared analysis (FTIR). The surface modification was explored by means of scanning electron microscope (SEM).
Results: All obtained results support the aggregation and formation of hydroxyapatite (Hap) layer with different amounts that depend on the type of transition metal added to the glass matrix.
Conclusions: The biodegradation data and spectral analysis of different samples may consider the material to be a good candidate for use as dental biomaterials.
A CAD-CAM Evaluation of Maxillary Canine Retraction Using Two Different Modalities with MBT Prescription-An In Vivo Study
Authors: Jacob George Jeryn
Published: June 2015

Objective: (1) To measure and compare the amount of maxillary canine retraction.
(2) To compare the rate of maxillary canine retraction.
Materials and Methods: This was a split mouth design study to compare the amount of maxillary canine retraction using two different modalities. The two modalities of maxillary canine retraction were conventional mechanics with E-chain extending from molar to maxillary canine on one side and the other modality was using orthodontic microimplants loaded with E-chain to the maxillary canine. The sample comprised 15 patients (9 male, 6 female, mean age 19.8 years; range 16-25 years) who were scheduled for extraction of all the upper first premolar. A brass wire guide and a peri-apical radiograph were used to determine the microimplant position. Titanium orthodontic microimplants 1.3 mm in diameter and 10 mm in length were placed between the roots of the second premolar and the first molar of the maxillary arch. After 15 days, the microimplants and the molars were loaded with continuous elastomeric chains expressing 150 grams for canine retraction. Pre-retraction and post-retraction study models were taken for measuring the amount of retraction. Study models were scanned and assessed using CAD-CAM.
Results: The total space closure on the molar anchor side was 4.62 mm (1.1 mm contributed by mesial molar movement) and microimplant anchor side was 4.12 mm. The rate of canine retraction on the molar anchor was 1.07 mm/month and 0.91 mm/month on the microimplant anchor side.
Conclusion: The amount and rate of canine retraction is similar when proceeded with a conventional or a microimplant supported canine retraction.
Incidence and clinical relevance of tibiofibular synostosis in fractures of the ankle which have been treated surgically
Authors: Droog R. , Verhage S. M. , Hoogendoorn J. M.
Published: June 2015

In this retrospective cohort study, we analysed the incidence and functional outcome of a distal tibiofibular synostosis. Patients with an isolated AO type 44-B or C fracture of the ankle who underwent surgical treatment between 1995 and 2007 were invited for clinical and radiological review. The American Orthopaedic Foot and Ankle Society score, the American Academy of Orthopaedic Surgeons score and a visual analogue score for pain were used to assess outcome.

A total of 274 patients were available; the mean follow-up was 9.7 years (8 to 18). The extent of any calcification or synostosis at the level of the distal interosseous membrane or syndesmosis on the contemporary radiographs was defined as: no or minor calcifications (group 1), severe calcification (group 2), or complete synostosis (group 3).

A total of 222 (81%) patients were in group 1, 37 (14%) in group 2 and 15 (5%) in group 3. There was no significant difference in incidence between AO type 44-B and type 44-C fractures (p = 0.89). Severe calcification or synostosis occurred in 21 patients (19%) in whom a syndesmotic screw was used and in 31 (19%) in whom a syndesmotic screw was not used.(p = 0.70). No significant differences were found between the groups except for a greater reduction in mean dorsiflexion in group 2 (p = 0.004).

This is the largest study on distal tibiofibular synostosis, and we found that a synostosis is a frequent complication of surgery for a fracture of the ankle. Although it theoretically impairs the range of movement of the ankle, it did not affect the outcome.

Our findings suggest that synostosis of the distal tibiofibular syndesmosis in general does not warrant treatment.

Cite this article: Bone Joint J 2015;97-B:945–9.
A regime of two intravenous injections of tranexamic acid reduces blood loss in minimally invasive total hip arthroplasty
Authors: Hsu C-H. , Lin P-C. , Kuo F-C. , Wang J-W.
Published: June 2015

Tranexamic acid (TXA), an inhibitor of fibrinolysis, reduces blood loss after total knee arthroplasty. However, its effect on minimally invasive total hip arthroplasty (THA) is not clear. We performed a prospective, randomised double-blind study to evaluate the effect of two intravenous injections of TXA on blood loss in patients undergoing minimally invasive THA.

In total, 60 patients (35 women and 25 men with a mean age of 58.1 years; 17 to 84) who underwent unilateral minimally invasive uncemented THA were randomly divided into the study group (30 patients, 20 women and ten men with a mean age of 56.5 years; 17 to 79) that received two intravenous injections 1 g of TXA pre- and post-operatively (TXA group), and a placebo group (30 patients, 15 women and 15 men with a mean age of 59.5 years; 23 to 84). We compared the peri-operative blood loss of the two groups. Actual blood loss was calculated from the maximum reduction in the level of haemoglobin. All patients were followed clinically for the presence of venous thromboembolism.

The TXA group had a lower mean intra-operative blood loss of 441 ml (150 to 800) versus 615 ml (50 to 1580) in the placebo (p = 0.044), lower mean post-operative blood loss (285 ml (120 to 570) versus 392 ml (126 to 660) (p = 0.002), lower mean total blood loss (1070 ml (688 to 1478) versus 1337 ml (495 to 2238) (p = 0.004) and lower requirement for transfusion (p = 0.021). No patients in either group had symptoms of venous thromboembolism or wound complications.

This prospective, randomised controlled study showed that a regimen of two intravenous injections of 1 g TXA is effective for blood conservation after minimally invasive THA.

Cite this article: Bone Joint J 2015;97-B:905–10.
Arthroscopic assistance does not improve the functional or radiographic outcome of unstable intra-articular distal radial fractures treated with a volar locking plate
Authors: Yamazaki H. , Uchiyama S. , Komatsu M. , Hashimoto S. , Kobayashi Y. , Sakurai T. , Kato H.
Published: June 2015

There is no consensus on the benefit of arthroscopically assisted reduction of the articular surface combined with fixation using a volar locking plate for the treatment of intra-articular distal radial fractures. In this study we compared the functional and radiographic outcomes of fluoroscopically and arthroscopically guided reduction of these fractures.

Between February 2009 and May 2013, 74 patients with unilateral unstable intra-articular distal radial fractures were randomised equally into the two groups for treatment. The mean age of these 74 patients was 64 years (24 to 92). We compared functional outcomes including active range of movement of the wrist, grip strength and Disabilities of the Arm, Shoulder, and Hand scores at six and 48 weeks; and radiographic outcomes that included gap, step, radial inclination, volar angulation and ulnar variance.

There were no significant differences between the techniques with regard to functional outcomes or radiographic parameters. The mean gap and step in the fluoroscopic and arthroscopic groups were comparable at 0.9 mm (standard deviation (sd) 0.7) and 0.7 mm (sd 0.7) and 0.6 mm (sd 0.6) and 0.4 mm (sd 0.5), respectively; p = 0.18 and p = 0.35).

Arthroscopic reduction conferred no advantage over conventional fluoroscopic guidance in achieving anatomical reduction of intra-articular distal radial fractures when using a volar locking plate.

Cite this article: Bone Joint J 2015; 97-B:957–62.
Should we all go to the PROM? The first two years of the British Spine Registry
Authors: Breakwell L. M. , Cole A. A. , Birch N. , Heywood C.
Published: June 2015

The effective capture of outcome measures in the healthcare setting can be traced back to Florence Nightingale’s investigation of the in-patient mortality of soldiers wounded in the Crimean war in the 1850s.

Only relatively recently has the formalised collection of outcomes data into Registries been recognised as valuable in itself.

With the advent of surgeon league tables and a move towards value based health care, individuals are being driven to collect, store and interpret data.

Following the success of the National Joint Registry, the British Association of Spine Surgeons instituted the British Spine Registry. Since its launch in 2012, over 650 users representing the whole surgical team have registered and during this time, more than 27 000 patients have been entered onto the database.

There has been significant publicity regarding the collection of outcome measures after surgery, including patient-reported scores. Over 12 000 forms have been directly entered by patients themselves, with many more entered by the surgical teams.

Questions abound: who should have access to the data produced by the Registry and how should they use it? How should the results be reported and in what forum?

Cite this article: Bone Joint J 2015;97-B:871–4.
Unfreezing identities: Exploring choral singing in the workplace
Authors: Balsnes Anne Haugland , Jansson Dag
Published: June 2015

The topic of this article is the emerging trend of singing at work. The discussion is exemplified by results from case studies of singing interventions carried out at two different work places. The research comprised group interviews, participant observation and questionnaires. Our phenomenological and hermeneutic approach focuses mainly on the employees’ experience of singing at work. The analysis was driven by thematic coding. The discussion is illuminated mainly by Etienne Wenger’s community of practice theory. The following research questions were developed: how do the members of a workplace community experience choral singing? What implications do the participants see for themselves as individuals and for the organization? We identified four axes of impact: enjoyment, comfort zone, communality, and identity and roles. A workplace choir can challenge perceptions about how collegues view each other and transform individual identities. Consequently, the choir may also change the workplace as a practice community.
Minimal Detectable Displacement Achievable by GPS-RTK in CZEPOS Network
Authors: Raška Martin , Pospíšil Jiří
Published: June 2015

In this paper we have made a brief study of RTK precision to estimate possibilities of network RTK using CZEPOS for purposes of geotechnic monitoring of landslides in real time. In this paper we describe a testing methodology, which resulted in estimation of point-position precision and describing minimal detectable positional change. Based on our results it is concluded that displacements could be detected with centimetre accuracy even with short-period observations.
Accuracy evaluation of pendulum gravity measurements of Robert von Sterneck
Authors: Pešková Alena , Holešovský Jan
Published: June 2015

The accuracy of first pendulum gravity measurements in the Czech territory was determined using both original surveying notebooks of Robert Daublebsky von Sterneck and modern technologies. Since more accurate methods are used for gravity measurements nowadays, our work is mostly important from the historical point of view. In previous  works, the accuracy of Sterneck’s gravity measurements was determined using only a small dataset. Here we process all Sterneck’s measurements from the Czech territory (a dataset ten times larger than in the previous works, and we complexly assess the accuracy of these measurements. Locations of the measurements were found with the help of original notebooks. Gravity in the site was interpolated using actual gravity models. Finally, the accuracy of Sterneck’s measurements was evaluated as the difference between the measured and interpolated gravity.
An Investigation into the Possibilities of BIM and GIS Cooperation and Utilization of GIS in the BIM Process
Authors: Tobiáš Pavel
Published: June 2015

In the coming years we will most probably watch a significant increase of the BIM (building information model) utilization in the AEC (Architecture/Engineering/Construction) sector even in the Czech Republic. Therefore, it would be reasonable to consider possible utilization of the well-established geographic information systems within the building information modelling process. This paper is based on the currently existing literature and is focused on the interrelationship between BIM and GIS. The main goal is to reveal potential fields of cooperation and to find possible utilization of GIS in BIM. To provide a theoretical framework, this article briefly introduces and defines the term of BIM and deals with the most important semantic models in AEC and 3D GIS IFC and CityGML. The paper also contains examples of specific efforts recently dealing with the BIM and GIS collaboration.
Temperature effects on the bridge structure during the all-day monitoring
Authors: Michal Ondřej , Urban Rudolf
Published: June 2015

In current time the large amount of pre-stressed bridge structures is used. Their horizontal and vertical displacements are well predicted, but for verification of theoretical results is necessary to measure real displacements of these structures depending on external conditions. Given by the complexity of the design and by the inhomogeneity of external influences (especially temperature of the atmosphere, insolation, wind speed, etc.) cannot yet be reliably determined the changes of the construction caused by the immediate state of the environment and to distinguish them from irreversible (permanent) deformation of the structure.

In this paper the deflection line of the bridge of general Chábera over river Labe during the all-day monitoring will be analyzed. There is dense coverage of stabilized points enabling accurate approximation of the displacement of the bridge structure. The paper is focused especially on temperature effects on the bridge structure. The temperature changes cause the deformation of the construction not immediately, but with the time shift between change of temperature and structure deformation. Although the points are stabilized on both sides of the bridge deck, for the analysis of results were used only the points on the left side of the main span, where the biggest vertical displacements was detected. For testing of dependence of the time shift between the structure deformations and the structure temperature the Pearson coefficient of correlation was used.
Post-transplantation diabetes mellitus: an overview
Authors: Sklyanik Igor Alexandrovich , Shamkhalova Minara Shamkhalovna , Shestakova Marina Vladimirovna
Published: June 2015

This review presents an analysis of clinical and experimental studies related to post-transplantation diabetes mellitus (PTDM) ? a specific complication after solid organ transplantation. A search of the databases eLibrary, PubMed and Scopus using the keywords ?posttransplantation diabetes mellitus?, ?new onset diabetes after transplantation?, ?transplantation? and ?immunosuppression? yielded in 523 results, including four from Russian literature (one original research manuscript). The analysis included original research, reviews, meta-analyses and monographs published not before 2005 in Russian and English. A total of 60 relevant original researches and reviews were included in this review. Diagnostic criteria, disease risk factors and potential pathogenic mechanisms were all considered. The mechanisms of the diabetogenic effect of modern immunosuppressive drugs were analysed. The principles of pre- and post-transplantation screening for PTDM and optimal management strategies for patients with PTDM are presented. The current controversial issues concerning the various aspects of PTDM are discussed.
Otimismo, burnout e estados de humor em desportos de competição
Authors: Berengüí Gil Rosendo , Ortin Montero Francisco , Garcés de los Fayos Enrique J. , López Gullón José M. , Pinto Alessandra
Published: June 2015

O objetivo desse trabalho é de analisar a relação entre o construto otimista, a síndrome de burnout e o estado de humor em esportistas em situação pré-competitiva. A amostra foi constituída por 227 lutadores que participaram do Campeonato de Espanha de Lutas Olímpicas. Os instrumentos utilizados são o LOT-R adaptação espanhola de Otero et al. (1998) do teste de Scheier e Carver (1985), em sua revisão Scheier, Carver e Bridges (1994) em o Inventario de Burnout para Esportistas (IBD). O IBD é uma adaptação para populações desportivas realizadas por Garcés de Los Fayos (1999) do Maslach Burnout Inventory (Maslach & Jackson, 1981) e o Profile of Mood States (POMS). Para a avaliação dos estados de humor foi aplicado de forma abreviada e adaptada por Fuentes, Balguer, Melía e García-Merita (1995), do instrumento original de McNair, Loor y Dropplemam (1971). Os questionários foram administrados durante o Campeonato de Espanha de Lutas Olímpicas, nos escalões Cadete e Sénior. Os resultados indicam uma relação entre otimismo e algumas dimensões do burnout como o esgotamento emocional e a despersonalização, assim como estados de humor como depressão, fadiga e cólera.
General decay in a Timoshenko-type system with thermoelasticity with second sound
Authors: Ayadi Mohamed Ali , Bchatnia Ahmed , Hamouda Makram , Messaoudi Salim
Published: June 2015

In this article, we consider a vibrating nonlinear Timoshenko system with thermoelasticity with second sound. We discuss the well-posedness and the regularity of solutions using the semi-group theory. Moreover, we establish an explicit and general decay result for a wide class of relaxation functions, which depend on a stability number μ.
Analytical characterization of some pasteurized apple juices during storage
Authors: Damian Cristina , Leahu Ana , Oroian Mircea , Ropciuc Sorina
Published: June 2015

The aim of the study was to assess the effect of three weeks of storage on the chemical and rheological properties of apple juices obtained from Idared and Jonatan apples variety. Total antioxidant activity, levels of bio-active compound groups and the viscosity were measured to characterize the investigated juices. The method applied for the determination of ascorbic acid concentration was with 2, 6-diclorophenolindophenol. Total phenols (TP) in apple juices were determined using the Folin-Ciocalteau method and antioxidant activity by the use of DPPH free radical method. The viscosity of apple juices was investigated by a rotational viscometer, Brookfield viscometer (Brookfield Engineering Inc., Model RV-DV I Prime) with RV spindles. During three weeks of storage, different rates of all measured properties have been observed decreasing for both studied apples varieties juices. The juices from Jonatan apples have higher antioxidant activities that are correlated with the higher content in polyphenols and lower values of viscosity.
Surface treatments applied on titanium implants
Authors: Cosma Sorin Cosmin , Balc Nicolae , Moldovan Marioara , Miron-Borzan Cristina Ștefana
Published: June 2015

The aim of this systematic review was to identify new methods of surface treatments applied on titanium grafts and their clinical and histological outcomes, including different routes for surface treatments, respectively the results of in vitro or in vivo tests. These surface modifications analysed meet three main requirements: to prevent nonspecific absorption of denatured protein on the surface, to attract native tissue cells or progenitor cells capable of differentiation in an appropriate manner or to facilitate biochemical signals to induce biochemical healing mechanisms. Therefore, cells will recognize these surface modifications and will be influenced in their adhesion behavior, profiling and differentiation. This review summarizes some of the recent developments in coatings for medical field.
Relative Concerns on Visible Consumption: A Source of Economic Distortions
Authors: Quintana-Domeque Climent , Turino Francesco
Published: June 2015

Do relative concerns on visible consumption give rise to economic distortions? We re-examine the question posited by Arrow and Dasgupta (2009) building upon their general framework but recognizing that relative concerns can only apply to visible goods (e.g., cars, clothing, jewelry) and that households consume both visible and non-visible goods. Contrary to Arrow and Dasgupta (2009), the answer to this question turns to be always affirmative: the competitive equilibrium will always be different than the socially optimal one, since individuals do not take into account the negative externality they exert on others through the consumption of the visible good, while the social planner does. If one invokes separability assumptions, then the steady state competitive equilibrium consumption of non-visible goods will be strictly lower than the socially optimal one.
Petrographic and mineral variability of the rocks accompanying selected coal seams of the Poruba beds and their influence of the trace elements content / Zróżnicowanie Petrograficzno-Mineralogiczne Skał Współ Występujacych Z Wybranymi Pokładami Węgla Z Warstw Porębskich I Jego W Pływ Na Zawartość Pierwiastków Śladowych
Authors: Kokowska-Pawłowska Magdalena
Published: June 2015

Streszczenie

Skały współwystępujące z węglem w wybranych pokładach warstw porębskich (610, 620, 630) reprezentowane są najczęściej przez iłowce oraz iłowce syderytyczne, a rzadziej przez mułowce i mułowce syderytyczmne. Sporadycznie występują piaskowce. Stwierdzono także występowanie przerostu z tonsteinem. Zależnie od odmiany petrograficznej skał stwierdzono w nich zróżnicowanie zawartości pierwiastków śladowych (Ba, Zn, Mn, V, Cr, Cu, Ni. Pb, As, Ga, B, Co, Ge, Be, Li, Cd, Ag, Sr - w kolejności malejącego udziału). Znaczna część pierwiastków wykazała wysoki i często dominujący udział w iłowcach. Stwierdzono także regionalne zróżnicowanie zawartości pierwiast- ków śladowych w skałach.

Badania korelacji pomiędzy zawartością pierwiastków śladowych a zawartością głównych mine- rałów w skałach potwierdziły powinowactwo wielu pierwiastków śladowych z substancją organiczną, minerałami ilastymi i węglanami. Zwraca uwagę występowanie korelacji licznych pierwiastków śladowych z substancją organiczną (węglem) przy stosunkowo niewielkiej liczbie pierwiastków korelujących z minerałami ilastymi.
Analiza zmian podaży gipsu w Polsce w świetle rozwoju odsiarczania spalin w elektrowniach konwencjonalnych / Analysis of the Changes in Polish Gypsum Resources in the Context of Flue Gas Desulfurization in Conventional Power Plants
Authors: Szlugaj Jarosław , Naworyta Wojciech
Published: June 2015

Streszczenie

Dwadzieścia lat temu w elektrowni Bełchatów uruchomiono pierwszą w Polsce instalację odsiar- czania spalin metodą mokrą, w której jako produkt uboczny otrzymuje się pełnowartościowy gips syntetyczny. W konsekwencji zobowiązań międzynarodowych odsiarczanie wdrożono stopniowo w wielu innych krajowych elektrowniach. W wyniku odsiarczania metodą mokrą wapienną na rynku surowców budowlanych pojawiły się duże ilości gipsu syntetycznego. Artykuł jest próbą oceny zmian na rynku gipsu w Polsce jakie dokonały się w wyniku tego procesu. Przedstawiono stan zasobów gipsu naturalnego oraz wydobycie w ostatnich dwóch dekadach. Poddano analizie proces wdrażania systemów odsiarczania w krajowych elektrowniach z podaniem zdolności produkcyjnej i produkcji rzeczywistej gipsów syntetycznych. Omówiono sposób zagospodarowania otrzymywanych gipsów syntetycznych. Porównano produkcję gipsów naturalnych i syntetycznych w ostatnim dwudziesto- leciu. Na podstawie oficjalnych planów rozwojowych polskiej energetyki przedstawiono prognozę podaży gipsów z odsiarczania w najbliższej dekadzie. W studium przypadku na przykładzie pro- jektowanej kopalni węgla brunatnego przedstawiono metodę prognozowania podaży gipsu z instalacji odsiarczania spalin w elektrowni opalanej węglem z tego złoża. W podsumowaniu podkreślono, że zmiany w pozyskaniu związków siarki są efektem postępu technologicznego, którego głównym motorem jest potrzeba ochrony środowiska naturalnego.
Parametry hydrogeologiczne skał drenowanych przez stare wyrobiska górnicze w rejonie Miedzianki i Ciechanowie (Sudety Zachodnie) / Hydrogeological Parameters of Rocks Drained by the Old Mine Workings in the Area of Miedzianka and Ciechanowice (Western Sudetes)
Authors: Wąsik Mirosław , Wąsowski Marcin
Published: June 2015

Streszczenie

Artykuł prezentuje wyniki badań parametrów hydrogeologicznych, wykonanych na terenach nieczynnych kopalń Cu, Ag i As w Miedziance i Cie cha nowi cach (Sudety Zachodnie). W profilu geologicznym wydziela się luźne osady czwartorzędowe oraz pokrywy zwictrzelinowc leżące na skalach krystalicznych masywu karkonosko-izerskiego oraz kaczawskiego lupkowo-zieleńcowcgo pasma fałdowego. Stwierdzono, że nieczynne wyrobiska górnicze decydują o wysokości potencjału zasobności. Najwyższe wartości tego parametru (powyżej 50 tys. m5) uzyskano dla rejonów naj- bardziej pociętych wyrobiskami górniczymi. Nie zaobserwowano wpływu wyrobisk górniczych na wielkości pozostałych parametrów skal. Oznaczenia wartości współczynników filtracji, porowatości efektywnej, odsaczalnośc i grawitacyjnej i wodochlonności wykonane w sąsiedztwie oraz w oddaleniu od wyrobisk bardziej zależą od litologii, lokalnej tektoniki oraz stopnia zwietrzenia.

W profilu występują dwie strefy' znacznie różniące się charakterem przepuszczalności i możli- wościami gromadzenia wód. Pierwszą tworzą zwictrzeliny charakteryzujące się wartościami współczynnika filtracji zwykle od 0,1 do kilkunastu md. Niższe wartości uzyskano dla zwietrzę lin gliniastych, natomiast najwyższe, osiągające kilkaset nv'd, dla ziarnistych zwictrzelin granitów. Zwictrzeliny charakteryzują się wysokimi wartościami współczynnika odsączałności grawitacyjnej od 0,17 do 0,37. Drugą strefę tworzą występujące niżej lite skały krystaliczne. Wyznaczony dla nich współczynnik filtracji szczelinowej osiąga maksymalnie wartości nieco ponad 0,4 m/d, a zwykle kształtuje się na poziomie 0,01-0,09 m'd. Skały krystaliczne charakteryzują wartości współczynnika szczelinowatości w zakresieod 0,0005 do 0,0455, zwykle rzędu 0,002-0,004. Spośród badanych skał krystalicznych, najkorzystniejszymi wartościami parametrów hydrogeologicznych charakteryzują się hornfelsy, amfibolity i granity. Wyznaczone parametry hydrogeologiczne skal krystalicznych wska- zują ogólnie na ich niską pojemność wodną. Wyższe właściwości kolcktorskie w ich obrębie należy wiązać z dyslokacjami i spękaniami ciosowymi.
Biomorphological Association and Path Analysis in Sunflower (Helianthus annuus L.)
Authors: Jocković Milan , Jocić Siniša , Marjanović-Jeromela Ana , Ćirić Mihajlo , Čanak Petar , Miklič Vladimir , Cvejić Sandra
Published: June 2015

In breeding process it is important to know the extent of association between the traits that affect the yield. Objective of this study was to determine genotypic and phenotypic correlation and path coefficients in 50 sunflower hybrid combinations in order to identify research priorities in sunflower breeding. Relationships between seed yield and five bio-morphological traits in sunflower (oil content, protein content, 1,000-seed weight, head diameter and plant height) were studied. Head diameter had the highest correlation coefficient with seed yield, at phenotypic and genotypic level. Path analysis revealed that all evaluated traits had positive influence on seed yield at both, genotypic and phenotypic, levels. The highest direct effect on seed yield was found for head diameter, while protein content had the lowest direct effect on seed yield. Study has shown that the greatest improvement in sunflower seed yield can be achieved through selection on head diameter.
Chemical composition of volatiles extracted from indigenous tree species of Uganda: composition of bark extracts from Psorospermum febrifugum and Milicia excelsa
Authors: Nagawa Christine Betty , Böhmdorfer Stefan , Rosenau Thomas
Published: June 2015

Trees with natural resistance to decay by pests contain extractives, which are candidates for wood preservatives. In this study, the bark of Psorospermum febrifugum Spach and Milicia excelsa Welw. was extracted with hexane, acetone, methanol, and dichloromethane by pressurized liquid extraction. The chemical analysis of the extracts was performed by gas chromatography-mass spectrometry and the identified compounds were reviewed for known bioactivity. The results show that these species contain compounds with known antimicrobial activity and as such could serve for the development of antifungal wood preservatives, especially for local usage.