bluuebunny/crossref_metadata_2025 huggingface dataset:
Immediate results of surgical treatment of autoimmune thyroiditis with the introduction of ­advanced surgical techniques
Authors: Sadikhov Fatta G.
Published: May 2023

Background.Immediate postoperative complications in the surgical treatment of autoimmune thyroiditis range from 8.5 to 15.0% of the total number of operated patients.
Aim.Improving the results of surgical treatment of patients with autoimmune thyroiditis through the introduction of advanced surgical techniques and the use of CO2 laser in surgical interventions.
Material and methods.The immediate postoperative results of surgical treatment of patients with autoimmune thyroiditis at the clinical base of the Scientific Center for Surgery named after M.A.Topchibashev for 20152021 were studied. The analysis was carried out in two groups with the inclusion of data from 207operated patients aged 27 to 73years, mostly patients with hypertrophic form of AIT. There were 183(88.4%) women and 24(11.6%) men. The first group consisted of 96(46.4%) patients who underwent an advanced surgical technique using a CO2 laser. The second group included 111(53.6%) patients who underwent surgery using traditional methods. The immediate postoperative specific complications (paresis of the larynx and hypoparathyroidism) and the results of surgical treatment of patients in two groups were compared. To test the statistical significance of differences, nonparametric Pearson's 2 and Student's t tests were used. Differences were considered statistically significant at p0.050.
Results.The number of patients with complications among the patients of the first group was 3(3.1%), among the patients of the second group 16(14.4%) (2=7.870, p=0.006). The greatest number of complications was noted in patients with large goiter and recurrence of the disease in those previously operated on for autoimmune thyroiditis. The proposed method using a CO2 laser in the surgical treatment of patients with autoimmune thyroiditis can reduce the incidence of laryngeal paresis (2=4.057, p=0.044), hypoparathyroidism (2=4.381, p=0.037) and mortality (2=3.840, p=0.050), reduce the duration of hospital stay by 22% from 9.6 to 7.4days (t=2.588, p=0.007).
Conclusion.The use of advanced surgical techniques, the performance of the operation in an adequate volume and the use of a CO2 laser made it possible to reduce the number of postoperative complications and improve the results of treatment of patients with autoimmune thyroiditis.
Pharmacological treatments for low back pain in adults: an overview of Cochrane Reviews
Authors: - -
Published: May 2023

This publication is the Russian translation of the Plain Language Summary (PLS) of the Cochrane Systematic Review: Cashin AG, Wand BM, O'Connell NE, Lee H, Rizzo RRN, Bagg MK, O'Hagan E, Maher CG, Furlan AD, van Tulder MW, McAuley JH. Pharmacological treatments for low back pain in adults: an overview of Cochrane Reviews. Cochrane Database of Systematic Reviews. 2023. Issue 4. Art. No.: CD013815. DOI: 10.1002/14651858.CD013815.pub2.
Role of Dexamethasone as an adjuvant in the treatment of intussusception: A prospective study
Authors: Raja Anakha , Gajanthody Suhitha , Deep Gagan , MS Ashraf , Zeeshan Mhaskar , B Harishchandra
Published: May 2023

Background: Intussusception is one of the most commonly encountered abdominal emergencies in children for which the preferred treatment modality has always been non operative hydrostatic reduction. Recurrence is a common concern after a successful hydrostatic reduction. Adjuvant treatment with pharmacological agents have been considered to reduce chances of recurrence. Aim: The study was conducted to examine the role of dexamethasone in decreasing early recurrent intussusception. Materials and methods: A prospective cohort study was conducted in a tertiary care center from June 2018- June 2022 on 51 pediatric patients, admitted with intussusception and divided into a dexamethasone and non-dexamethasone group. Data was collected regarding demography, rate of recurrences, duration of hospital stay, surgery performed if any including the intraoperative findings and associated complications. The level of significance was set at 5%. SPSS version 27 was used to perform the statistical analysis. Result: After ultrasound-guided hydrostatic reduction, the dexamethasone group showed significant reduction in recurrence, compared to the non-dexamethasone group. In this study, 7 cases showed recurrence despite three attempts of hydrostatic reduction and intraoperatively noted to have a pathological lead point. Conclusion: Dexamethasone is one of the greatest discoveries of the 20th century with its vast use in multiple diseases. The use of dexamethasone during hydrostatic reduction of intussusception in a pediatric population makes it a wonderful drug with remarkable results and patient outcome.
Te Puna Taiao: How can our outdoor spaces provide meaningful interactions for tamariki and communities?
Authors: Simmonds Hannah , Green Erin
Published: May 2023

The connection between the environment and our individual wellbeing can be seen through our indigenous histories, traditional ways of living, and understanding of health benefits of living in balance with our land, water, and sky. Educational settings can be reimagined and transformed to better use outdoor spaces and build the wellbeing of our tamariki and their whānau. This article shares learnings from five communities that have been on a journey to understand how to redesign and use their educational spaces differently so that their students, and the wider communities they serve, can experience improved wellbeing.
Learning from each other: A framework from the field
Authors: Chu-Fuluifaga Cherie , Reynolds Martyn
Published: May 2023

Parents of Pacific learners are clear about what they want their childrens’ teachers to know. Teachers can make good sense of such knowledge when it is gifted to them if they are well-supported. This article is a preliminary account of a Teaching and Learning Research Initiative project, Learning From Each Other. The article describes an appropriate learning framework to support teachers of Pacific learners which leverages the potential of parent–teacher relationships to be the beating heart of Pacific education. The argument, driven by data from two case studies, points to the significance of a number of features as framework elements when seeking sustained positive change in Pacific education. These are: a context in which teachers see, and are motivated by, a need for change; talanoa as supportive exploratory process; exposure to resources (Pacific parent voice, Pacific origin theory, navigators); sufficient opportunity to learn; and a growth mindset. By linking these elements into a framework, we seek to support the effectiveness of activities designed to help teachers serve their Pacific (and other) learners better.
Professional learning in mathematics
Authors: Proffitt-White Rob , Fisher Jonathan , Roberts Julie
Published: May 2023

Late in 2022 Julie Roberts and Jonathan Fisher caught up with Rob Proffitt-White to find out about the recent professional learning workshops he ran with teachers and school leaders around New Zealand. They asked Rob about the underlying approach to the short-term Just-in-Time Maths initiative and his thoughts about future professional learning in mathematics.
Pulmonary hypertension: modern methods of treatment and ways of their long-term development.
Authors: Zagrebelnaya Anna V. , Korokina Liliya V. , Malorodova Tatyana N. , Shcheblykina Olesya V. , Avtina Tatyana V. , Bolgov Anton А. , Malyutina Elena S. , Simonov Vladislav I. , Travkin Vladislav A. , Dmitriev Artem А. , Aripov Amonullo A. , Shcheblykin Dmitry V.
Published: May 2023

Introduction: The purpose of this work is to review the main pathogenetic mechanisms of the development of PH, as well as modern established methods of treatment of various types of PH and to consider new, most relevant and promising possibilities of therapy for this pathology.
Etiology, pathogenesis and epidemiology: In the modern structure of diseases, pulmonary hypertension plays a significant role, affecting about 1% of the population. However, each of its five main groups has its own characteristics. The causes of pulmonary hypertension can be a polyetiological violation of the processes of endotheliocyte apoptosis and angiogenesis, passive transmission of increased pressure from the left heart to the small circulatory system, chronic hypoxia, leading to vascular remodeling, and many others. In general, it is worth noting that, despite the multiplicity of etiological factors, the main pathogenetic link in the development of pulmonary hypertension is endothelial dysfunction.
Treatment and promising areas of research: This article discusses the main established approaches to the treatment of pulmonary hypertension: general recommendations for patients, drugs used as supportive nonspecific therapy, as well as specific conservative and radical methods of treatment. In addition, the main modern directions of scientific research in the field of treatment of pulmonary hypertension are described. Such promising methods as the use of stem cells, gene therapy and epigenetic drugs are considered.
Conclusion: Despite active research and many different drugs intended for the treatment of pulmonary hypertension, this pathological condition remains an urgent health problem. Thus, the search for new points of application of therapy and fundamentally new methods of treatment of pulmonary hypertension remains relevant to this day.
Araplarda Şiir: Kadim Edebî Türün Kültürel Özellikleri ve Maddi Destekçileri
Authors: KAHRAMAN Ferruh
Published: May 2023

Çalışmanın konusu, Araplarda Şiir: Kadim Edebî Türün Kültürel Özellikleri ve Maddi Destekçileri’dir. Problemi ise Araplarda şiirin kültür bakış açısıyla değerlendirilip değerlendirilmeyeceği ile şirin bir yaşam tarzı, estetik, sembolik ve anlamsal boyutunun sorgulanmasıdır. Makalede sadece Arap şiiri kültürel yönden değerlendirilmekle kalmamış; şiirin gelişimini sağlayan kültürel dinamiklere vurgu yapılmıştır. Modern dönemde toplum araştırmalarında büyük gelişmeler olmuş; sosyoloji, antropoloji, arkeoloji ve kültür tarihi gibi yeni bilimler teşekkül etmiştir. Bu bilimler içerisinde sosyoloji öncelikle Batı toplumlarını kendisine inceleme konusu edinirken antropoloji de Batı dışı toplumları araştırmıştır. Arkeoloji ve antropoloji gibi bilimler de kadim toplum ve insanlarla insan çeşitliliğini incelemiştir. Bu çalışmalar neticesinde mevcut ve kadim toplumların kültürlerine dair pek çok veri toplanmış; insanlığın tarihi anlaşılmaya ve geleceği de tahmin edilmeye çalışılmıştır. Ancak kadim toplumlardan olan Arapların şiiri herkes tarafından malum ve Araplar şiir konusunda ileri bir toplum iken şiirin kültürel yönü yeterince değerlendirilmemiştir. Son dönemde bu alanda yapılan çalışmalar, yöntem olarak geçmişin bir tekrarı niteliğindedir. Bu çalışmalar da muhakkak önemlidir ancak geçmişte olduğu gibi Arap şiiri, tarih, muhteva, şekil, mevzu ve şairler bağlamında ele alınmakta, şiirin başlangıç tarihi ile düzenlendiği panayırlara vurgu yapılmaktadır. Oysaki Arap şiirinin de günümüzde önemli görülen kültür külliyatı etrafında, kültürün dinamikleri ve kültürel bakış açısıyla ele alınma zamanı gelmiştir. Bu nedenle çalışmada, kadim Arap şiiri kültürel açıdan değerlendirilmiştir. Çalışmada nitel yöntem tekniklerinden doküman incelemesine baş vurulmuş; Arap edebiyatı ile ilgili eserlerin yanı sıra bazı kültür ve kültür tarihi ile ilgili kitaplara müracaat edilmiştir.

Anahtar Kelimeler: Arap Dili ve Belagati, Arap, Şiir, Kültür, Sembol.
Fıkhın Kelâma Tercihi: İmam Ebû Hanîfe ve İmam Şâfiî Örneği
Authors: AKAY İhsan
Published: May 2023

İslâm düşünce ve ilim tarihinde ayrı bir ehemmiyete sahip kelâm ve fıkıh ilimleri, teşekkül süreçlerinde diğer ilimlerle olan etkileşimleriyle ve dinî tefekkürün tekâmülüne dair katkılarıyla öne çıkmışlardır. Literatürde fıkhın lisanî, şer‘î, aklî ve amelî cihetini temsil eden alan usûl-i fıkıh ve fürû-ı fıkıh, akideye dair kısım ise usûlü’d-dîn veya fıkhu’l-ekber şeklindeki kavramlarla yaygınlık kazanmıştır. Bu iki disiplin özelinde İmam Ebû Hanîfe ve İmam Şâfiî’nin içtihadları, fetvaları ve düşüncelerinin ifrat ve tefrit girdabında istisnasız her asırda güncelliğini sürdürmüş olmaları dikkatimizi çekmiştir. Nitekim bu imamların kelâmla ilgilendikleri halde ona karşı mesafeli durdukları yönünde bazı nakillere yer verilmiştir. Meşhur öğrencileri de onların kendilerine bu manada tavsiyelerde bulunduklarını dile getirmişlerdir. Binaenaleyh bu çalışma, mezkûr hususların arka planını irdelemek amacıyla hazırlanmıştır. Bu amaca matuf olmak üzere konunun ana mihverinde iki imamın fıkıh ilmini tercih etme sebepleri genel bir kritiğe tâbi tutulmuştur. Neticede dönemin itikadî gelişmeleri karşısında her iki imamın da benzer endişeleri taşıdıkları ve fikirlerinin örtüştükleri görülmüştür.
Kur’an Bütünlüğünde Şefaatle İlgili Ayetlerin Tahlili
Authors: PİŞGİN Yasin
Published: May 2023

Geçmişte olduğu gibi günümüzde de şefaat inancı, kimi kesimlerce reddedilirken, kimi kesimler tarafından da kabul edilmekte ve her iki taraf da görüşlerini Kur’an ile temellendirmektedir. Kur’an’ı incelendiğimizde konuyla ilgili ayetlerin bir kısmının şefaatin varlığından, bir kısmının da yokluğundan bahsettiğini görmekteyiz. Bâtılın hiçbir şekilde kendisine nüfuz edemediği/edemeyeceği ilahi bir kitap olan Kur’an’ın en önemli özelliklerinden biri de onda birbirini yalanlayan çelişkili bilgi ve hükümlerin olmamasıdır. Şu hâlde şefaatin hem inkârı hem de ispatı konusunda referans alınan Kur’an’ın, aynı şefaati hem onaylaması hem de reddetmesi ilahi kelam ile bağdaşmayan paradoksal bir durumdur. Bu da bizi Kur’an’ca makbul ve merdut görülen iki ayrı şefaat türünü ve aralarındaki farkları tespite, dolayısıyla da ilgili ayetleri bütünsel olarak incelemeye sevk etmektedir. Bu itibarla biz bu makalede, şefaatin imkân ve imkânsızlığından bahseden ayetleri Kur’an bütünlüğünde ele almaya ve Kur’an’ın reddettiği ve onayladığı şefaatin mahiyetini tespit etmeye çalışacağız.
منهج التخريج في حل القضايا الفقهية المعاصرة في نماذج فتاوى المجلس الأعلى للشؤون الدينية
Authors: DADAŞ Mustafa Bülent
Published: May 2023

يتناول هذا المقال منهج التخريج في حل القضايا الفقهية المستجدة وتطبيقات المجلس الأعلى للشؤون الدينية التركية هذا المنهج في فتاواه. ويعرَّف التخريج بأنه تتبع الأحكام الفرعية لمذهب والوصول منه إلى قواعد أصولية أو فقهية ثم إلحاق أحكام المسائل الجديدة بحكم قاعدة يدخل تحتها. سنقوم أولًا بتعريف المجلس الأعلى بإيجاز شديد مع بيان دوره ومساهمته في حل القضايا الجديدة وتوحيد الفتاوى في تركيا مركزًا على أنه ورث المشيخة الإسلامية في الدولة العلية العثمانية. ثم نبين معنى التخريج الفقهي لغة واصطلاحًا وأنواعه وتاريخه ودوره في تطوير الفقه الإسلامي ومدى إمكان الاستفادة منه في حل القضايا الفقهية الجديدة، وسنعرض من فتاوى المجلس التي أسست على منهج التخريج: فتوى التأمين التجاري، وزرع الأعضاء، وصكوك الإجارة المعتمدة على الذهب وتأثير التطعيم على الصيام. ومن خلال عرضها سيتبين أن التخريج مصدر خصب ومعين لا ينضب في الوصول إلى الأحكام الشرعية العملية، ومنهج سليم يستطيع به الفقيه الحِفاظ على الانضباط في آرائه وبه يطور مذهبه الذي ينتمي إليه ويجعله حيًّا فعَّالًا ومستعدًّا لتلبية حاجات الفقيه في مواجهته قضايا زمانه.
Secâvendî’ye Göre Kur’ân’daki Vakf-ı Lâzım Remizlerinde Vasl Yapmanın Anlama Etkisi
Authors: BULUT Hasan
Published: May 2023

Every word of the Qur'an ensures the understanding of the divine will. The foundation signs in it were created for this purpose. Just like the punctuation marks that ensure the correct understanding of a Turkish sentence, the foundation marks in the Qur'an have assumed the same function. The signs of foundation, which give the opportunity to breathe by interrupting the recitation at the places where the mana is completed, and the signs of ibtida, which provides the recitation starting from the appropriate place for the integrity of the meaning, have a significant importance in the authentic interpretation of the Qur'an.

The scholar, who wrote very important works related to the field and brought an independent topic under the name of "Secâvend" to the science of recitation, undoubtedly Muhammad b. Tayfur es-Secavendi. According to him, it is considered obligatory to dwell on the foundation denoted by the remzi (م) in the mushafs. Because when vasl is performed in these places, the nature and meaning of the verse changes. Based on these reasons, a foundation is different from other types of foundations. In this study, the signs of the need for foundation were examined within the framework of the verse integrity, and it was analyzed why Secavendi considered it necessary to make a foundation, taking into account the possible meanings that may occur in the case of vasl.
Modern Dönemde Nahiv-Mantık Tartışması -Aristo Mantığı-Arap Grameri İlişkisi Üzerine Üç Görüş-
Authors: AYDIN Bünyamin
Published: May 2023

Aristo mantığı-Arap grameri ilişkisine dair tartışmalar erken dönem dilcileri arasında yaşandığı gibi modern dönem dilbilimcileri tarafından da sürdürülmüştür. Bu tartışmalar mantık ve nahiv ilimlerinin amaç ve işlevleri etrafında şekillenebildiği gibi mantığın nahvin doğuşunda ve gelişmesinde etkili olup olmadığı konusuna da yoğunlaşmıştır. Sözü edilen etkiye dair tartışmalar nahiv ilminin özgünlüğü kavramını gündeme getirmiştir. Bu çalışma Aristo mantığının Arap gramerinin doğuşu üzerinde etkili olup olmadığı etrafında şekillenen tartışmaya ilişkin üç yazıyı ele almaktadır. Üç ayrı görüşü temsil eden bu üç yazı sözü edilen etkinin varlığı, varsa metot ve içerik bakımlarından ne düzeyde gerçekleştiği gibi hususları incelemektedir. Çalışmada konunun tarihsel bağlamına ilişkin olarak Süryânî gramercilerin yaptıkları çalışmalar, mantık külliyatından Arapçaya yapılan ilk çeviriler, Sîbeveyhi’nin hocalarının günümüze ulaşmayan eserleri ve İskenderiye-Bergama gramer okulları gibi hususlara dair bilgiler verildikten sonra söz konusu üç yazıdaki değerlendirmeler, müelliflerin diğer eserleri de göz önüne alınarak temel nahiv eserlerine, Aristo’nun mantık kitaplarına ve gerek klasik gerek modern dönemde yapılmış bazı Aristo çevirilerine müracaat edilmek suretiyle ele alınacaktır.
Assessment of Issues Related To Environmental Degradation in the Niger Delta Region by Selected Nigerian Newspapers
Authors: Nwokezi John Ikoro
Published: May 2023

This study focused on assessment of issues related to environmental degradation in the Niger Delta Region by selected Nigerian newspapers. The Region is faced with the problem of oil-related environmental degradation; the press is the watchdog of society which is supposed to draw the attention of all and sundry to environmental issues. In this vein, the study had a sample of 324 in a population of 2,193 issues of Nigerian newspapers. The research design used for this study was a content analysis of the coverage patterns of oil-related environmental degradation issues in the Niger Delta Region by Nigerian newspapers: The Guardian, Daily Sun and The Nation. The objective was to identify issues of oil-related environmental degradation reports in the newspapers across the years (2020-2021). The trends of their reports showed that oil- related environmental degradation stories were on the increase from 2020 to 2021.The study recommended that journalists and other media organizations should be trained and assigned special reporters to cover oil-related environmental degradation issues in the Niger Delta Region of Nigeria.
Alvin Boyarsky y la influencia de Chicago á la carte en la revolución docente de la Architectural Association
Authors: Cano-Ciborro Victor
Published: May 2023

Alvin Boyarsky, arquitecto y futuro dean de la Architectural Association, aterriza en Chicago en el otoño de 1965 como associate dean del College of Architecture and Arts de la University of Illinois de Chicago. Dicha experiencia, más que acomodarle en la burbuja académica, hace que se despierte en él un tremendo interés por las condiciones urbanas y arquitectónicas que sufrían los habitantes más vulnerables de la ciudad en aquella época, fundamentalmente población afroamericana. En este contexto, Boyarsky se convierte en una figura clave del activismo de la época, situación que se ve reflejada en su muy infravalorada obra Chicago à la Carte. En ella, además de ofrecer una historia paralela de la ciudad, acaba mostrando en sus últimas páginas la necesidad de una arquitectura y urbanismo preocupado por el contexto, donde más que objetos y formas, se representen a los cuerpos que lo habitan y las fuerzas invisibles que se generan. Tras un análisis detallado del libro, el artículo vincula directamente dichas aproximaciones con la innovadora y radical metodología docente que aplicó a la Architectural Association, en Londres, desde su llegada en 1971 hasta su muerte en 1990. Un método que convirtió a una universidad al borde del colapso en un referente global, educando a los más prestigiosos arquitectos de las últimas décadas, como es el caso de Rem Koolhaas o Zaha Hadid.
Retrospective Analysis of 48 Patients Reoperated for Carpal Tunnel Syndrome
Authors: KESİLMEZ Emrullah Cem , YÜKSEL Zafer
Published: May 2023

Carpal tunnel syndrome (CTS) is a condition in which the median nerve is compressed between the transverse ligament and the carpal bones. There are various techniques used in the surgical treatment of CTS. The present study aimed to investigate the reasons for reoperation by examining the reoperated cases diagnosed with CTS. Patients who underwent surgery for CTS at Kahramanmaraş Sütçü İmam University Department of Neurosurgery between January 1, 2015 and September 1, 2022 were evaluated retrospectively. All patients were operated by the same surgical team. Patients who underwent two or more operations with the same diagnosis were included in the study, while those operated for the first time due to CTS and with missing data were excluded. The included patients were analyzed in terms of gender, age, occupation, side of the surgery, presence of systemic diseases causing CTS such as diabetes mellitus (DM), number of the operations they underwent, time until the next operation, surgical technique, and medical branch that performed the surgery (orthopedics, neurosurgery, or plastic surgery). Forty-eight patients who met the study criteria were evaluated. Out of the 48 reoperated patients, 14 were male and 34 were female. Eighteen patients had been operated using the mini-incision open method, while 22 had undergone laparoscopic surgery, including 14 patients with biportal endoscopic surgery, and eight with uniportal endoscopic surgery. Out of the 48 patients, 31 (64.6%), 11 (22.9%), and six patients were first operated by orthopedic and traumatology physicians, plastic and reconstructive surgeons, and neurosurgeons, respectively. The use of open surgical technique is the gold standard in CTS and complete incision of the transverse ligament provides complete decompression of the median nerve. We believe that decompression with closed or small incisions due to aesthetic concerns may not be sufficient and may increase the risk of complications.
Effects of COVID-19 Pandemic on Clinical Education: Looking Through Lens of Intern Nursing Students
Authors: GÜNDOĞDU Handenur , DEMİR Rümeysa , TANRIKULU Fatma , DEMİR Mustafa , KUZGUN Hürmüs , DİKMEN Yurdanur
Published: May 2023

The active participation of nursing students in clinical practice during the Covid-19 pandemic has played a critical role in maintaining patient care and the struggle against the pandemic. However, the limited clinical experience of the students caused them to have many problems in this process. In addressing the effects of the pandemic on clinical education, the opinions of the nursing students who experience the process in person is quite valuable. This study aims to investigate the perceptions and experiences of intern nursing students receiving clinical education during the COVID-19 pandemic. The research was carried out using the phenomenological research model from qualitative research methods. The research participants consisted of intern nursing students (n = 23). The research data were obtained using the semi-structured question form created by the researchers. The data were recorded in a computer environment, read in depth, analyzed through the content analysis method, and categorized into specific themes and sub-themes. The mean age of the students was 22.09±1.125 years. Female students constituted 91.3% of the sample. As a result of the focus group interviews, four main themes were identified: emotional effects, social effects, professional effects, and recommendations on clinical education. It was determined that nursing students receiving clinical education during the pandemic were determined to be affected in emotional, social, and professional aspects. In addition, the nursing students made certain recommendations to overcome the process more easily.
Comparison of Nutritional Status with Serum Vitamin D and B12 Levels in Pregnant Women with Gestational Diabetes
Authors: ÇELENK Tevhide , CEBİ Aysegul
Published: May 2023

Objective: In this study, it was aimed to evaluate the nutritional adequacy status of pregnant women with gestational diabetes and to examine the relationship between biochemical parameters such as vitamin D, vitamin B12, hemoglobin, hematocrit and fasting glucose.

Methods: In the study, serum vitamin D and B12 levels of 130 pregnant women between 24-28 weeks of gestation were examined. As a result of 75-gram oral glucose tolerance test, 70 pregnant women were diagnosed with gestational diabetes mellitus (GDM). The control group consisted of 60 healthy pregnant women. Nutritional factors were obtained through a questionnaire (anthropometric measurements, micronutrients, 3-day food consumption frequency, use of vitamin supplements) and groups were compared in terms of biochemical parameters (vitamin D, vitamin B12).

Results: Pregnant women with GDM; mean age (30.34 ± 5.28), family history of diabetes (17.1%), pre-pregnancy body mass index percentage (54.3%), rate of skipping meals were higher. The rate of use of vitamin and mineral supplements in pregnant women with GDM was low. According to the analysis of 3-day food consumption records of pregnant women with GDM, it was determined that the intake of micronutrients vitamin D and vitamin B12 was insufficient. Biochemical parameters such as vitamin D, vitamin B12, hemoglobin and hematocrit were found to be lower in pregnant women with GDM.

Conclusion: GDM is the most common endocrinological disorder in pregnancy. The study showed that inadequate nutrient intake negatively affects blood glucose levels and biochemical findings. Individuals with GDM should be referred to a nutritionist, medical nutrition therapy (TBT) appropriate for their individual characteristics should be given and monitored.
Investigation of Senior Nursing Students' Views on Internship Program
Authors: ERBİL Nülüfer , DURGUN Hanife , KALKAN UĞURLU Yasemin , BAYKAL TOP Figen , BOSTAN Özgül , BÖLÜKBAŞ Nurgül , ÇATIKER Aslıhan , GÖK UĞUR Hacer , GÜNAYDIN Nevin , KAHRAMAN Azize Nuran , ŞAHİN Ebru
Published: May 2023

Objective: The information to be obtained from this study may contribute to the improvement of the clinical qualifications and learning outcomes of intern nurses. This study was conducted to determine the views of fourth-year nursing students about the internship program

Methods: The population of the descriptive study was 97 students in the 4th grade of the nursing department of a state university in the Ordu The sample of the descriptive study was 96 nursing students. The data were collected Nightingale Intern Program Evaluation Scale (NIPES).

Results: In this study, nursing students' NIPES total scale score was 3.81±0.75, sub-dimension of the scale mean scores were 3.81±0.75 for "Professional Development", 3.83±0.78 for "Personal Development", and 3.96±0.89 for "Guidance/Counseling", 4.13±0.88 for "General Features of the Program", 4.03±0.87 for "Application Field Features", 3.80±0.97 for "Communication with Patients and their Relatives”. According to the presence of nurses in their first-degree relatives, the mean scores of the sub-dimensions "Professional Development", "Personal Development", "Guidance / Counseling", "General Characteristics of the Program", "Patient and Relatives" and "Communication" of NIPES were were statistically significantly different between the groups (p<0.05).

Conclusion: Nursing students had a positive opinion about the internship program. However, it is important for program managers to take precautions to increase the success of the internship program.
Expression pattern and subcellular localization of p62/SQSTM 1 during mouse oocyte maturation
Authors: UYSAL Fatma , BOZDEMİR Nazlıcan , ÇINAR Özgür
Published: May 2023

Objective: Autophagy is a survival mechanism, and it is initiated by several factors such as oxidative stress. Cells give autophagy response against oxidative stress through Nrf2-Keap1-p62 pathway. p62 or Sequestosome 1 (SQSTM 1) which takes place during autophagy, and it is showed that p62 plays critical role during primordial follicle formation. During oocyte maturation, Germinal Vesicle (GV) oocytes resume meiosis with the beginning of puberty and progress through Metaphase I and Metaphase II stages. Metaphase II (MII) oocytes are ready to be fertilized and until fertilization they are arrested at metaphase II stages. It is known that oxidative stress is increasing during oocyte maturation. However, it is not shown that spatial and temporal expression of p62 throughout oocyte maturation. Thus, the aim of the study was to reveal expression pattern and the subcellular localization of the p62 protein in mouse GV, MI and MII oocytes.

Methods: GV oocytes were received from female Balb/C mice at 4 weeks aged and GV oocytes were cultured for 8h to develop into MI oocytes and for 14h to mature into MII oocytes. Then, expression of p62 protein was observed in oocytes at GV, MI and MII maturation stages by using immunofluorescence method.

Results: Our results showed that there is a significant increasing p62 expression when GV oocytes are compared to MI and MII oocytes, but there is no difference between MI and MII oocytes. Moreover, we revealed that p62 is localized in cytoplasm of GV oocytes, while it is localized around chromosomes in MI and MII oocytes.

Conclusion: In conclusion, our results indicate that further study is mandatory to understand the participation of p62 during meiosis, and the impact of p62 during oocyte maturation.
Synthesis, Characterization and Investigation of Antimicrobial Activity of Orthophtaldehyde Nanoflowers
Authors: CAN SEZGİN Gülten , ILDİZ Nilay
Published: May 2023

Objective: Endoscopy procedures are frequently performed in gastroenterology clinics, and disinfection cost, corrosion and toxicity are important problems in this area. For this purpose, hybrid nanoflowers at various pHs were synthesized with orthophtaldehyde (OPA), which has an important in disinfection in these clinics, and the hybrid nanostructures obtained by reducing the amount of orthophtaldehyde use were aimed to also increase the effectiveness of the disinfectant.

Methods: OPA nanoflowers (OPA NFs) were synthesized and their effective diameters (hydrodynamic diameters) and surface charges were determined by dynamic light scattering (DLS) and Zeta potential (ZP) measurements, respectively. Antimicrobial activities of orthophtaldehyde and OPA NFs against Staphylococcus aureus (S. aureus) ATCC 25923, Escherichia coli (E. coli) ATCC 35218 and Candida albicans (C. albicans) ATCC 90028 standard strains were evaluated by the liquid microdilution method using percent inhibition method.

Results: OPA-based OPA-Cu2+hybridnano flowers (OPANF) were synthesized successfully at different pH values (pH 7.4, 9 and 11). The most effective antimicrobial activity was observed in the nanoflowers synthesized at pH=7.4 for all tested microorganisms. Although the antimicrobial activity decreased as the pH value increased, NFs activity was higher than OPA alone at all pH values (p<0.001). In this study, NFs synthesized with 0.02 mg/ml OPA were found to be 5.2 times more effective for C.albicans, 5.75 times for E.coli and 4.4 times for S.aureus than OPA(0.02 mg/ml).

Conclusion: NFs showed very high antimicrobial activity compared to OPA and also promise to be a preferred agent in medical device disinfection providing a high level of disinfection with the use of a few amounts of OPA that use in clinics.
Quality of life in women under 65 years of age with diabetes and affecting factors: A cross-sectional study
Authors: YILDIZ KARADENİZ Ebru , KAPLAN SERİN Emine
Published: May 2023

Objective: The study was conducted in the cross-sectional manner to determine the factors affecting the quality of life in women 65 years under with diabetes, to ensure the guide women in the management of the disease.

Methods: This study was conducted in the cross-sectional manner with 134 female patients with diabetes. The data were collected using the "Personal Information Form" and the “The World Health Organization Quality of Life Instrument Short Form”. Descriptive statistical analyzes were used to evaluate the data, and correlation and regression analyzes were used to evaluate the effects of independent variables.

Results: In the correlation analysis made for the relationship of some variables with the quality of life, it was determined that there was a positive significant relationship between age and duration of marriage variables, physical area, mental area, environmental area, general health, and total quality of life. It has been determined that the variables of residence, income status, duration of marriage, presence of gynecological disease, number of births, number of living children, family planning use status, fasting and postprandial blood sugar variables affect the quality of life. It was determined that the variables included in the model explained 61% of the quality of life.

Conclusion: Age, duration of marriage, geographical conditions of the place of residence and income status, quality of life also varies according to gender, as gynecological diseases experienced, pregnancy, and family planning use status, fasting and postprandial blood sugar variables affect the quality of life.
Reduced levels of plasma strong antioxidant uric acid in children with Autism Spectrum Disorder and Attention deficit-hyperactivity disorder
Authors: ESNAFOGLU Erman , YURDAKUL ERTÜRK Emine
Published: May 2023

Objective: Uric acid (UA) is one of the most powerful antioxidants in human body fluids, as well as being the end product of purine metabolism. UA alone constitutes half of the scavenging effect of oxidant substances in the plasma.It has proinflammatory and metal chelation effects. In this study, UA levels and UA situation according to the normal range were investigated in patients with Autism Spectrum Disorder (ASD), and Attention deficit-hyperactivity disorder (ADHD).

Methods: Eighty-two ASD, 28 ADHD patients and 66 healthy control subjects were compared and serum UA levels were measured. ASD and ADHD severity were determined by CARS and Atilla Turgay ADHD scale. K-SADS-PL was administered to all subjects over the age of 6 years.

Results: UA levels were found to be significantly lower in the ASD and ADHD groups. UA levels were found to be lower than the normal range in nearly half of the ASD and ADHD groups. This rate was found to be 18.2% in the control group.

Conclusion: it was determined that UA levels were low in ASD and ADHD patients. It can be suggested that it may play a role in the pathophysiology of ASD and ADHD. UA may be a potential treatment target.
Effectıveness of Curcumın on Tracheal Anastomosıs Created in the Rat Model
Authors: YILDIZ Muhammed Gazi , KILINÇ Emine , YALÇIN Nida , ÇAKAN Dogan , ORHAN İsrafil , KARA İrfan , YOLDAŞ Atila , DOĞANER Adem
Published: May 2023

Objective: We aimed to investigate the effect of curcumin on tracheal wound healing in the anastomosis model following tracheal incision in rats.

Methods: Twenty-one healthy male Wistar Albino rats were included in the study. A horizontal incision was made between the 2nd-3th rings of the rat trachea and damage was created in the inner tracheal mucosa. Tracheal incision area was sutured and anastomosis was performed. Rats were divided into three groups. Ringer was given to the first group, corticosteroids to the 2nd group, and curcumin to the 3rd group for 28 days. The rats were sacrificed on the 28th day and the tracheal anastomosis line samples were sent for histological examination. Wound healing parameters, tracheal lumen width, wall thickness, and stenosis index were evaluated.

Results: Statistically significant difference was detected in tracheal lumen width and wall thickness in the curcumin group (p<0.05). Statistically significant differences were observed in the curcumin group in parameters of inflammation, collagen production and fibrosis. (p<0.05).

Conclusion: It is important to prevent the formation of tracheal stenosis, which is difficult to treat in clinical practice. Desired results cannot be achieved in the side-effect profile of some medical drugs used in this regard. We found the positive effect of Curcumin in the prevention of stenosis following tracheal injury.
The Difficulties Experienced by Nurses Working in A Tertiary Hospital in Turkey while Providing Health Care to Immigrant and Refugee Patients and Intercultural Sensitivity
Authors: ÖZDEMİR Şule , KIYMAZ Dilek
Published: May 2023

Objective: This research was carried out to evaluate the difficulties experienced by nurses during the delivery of health care to immigrant and refugee patients and their intercultural sensitivity.

Methods: The descriptive-cross-sectional study was conducted with 132 nurses. In the study, "socio-demographic questions, questions about the difficulties experienced while caring for immigrant/refugee patients" and "Intercultural Sensitivity Scale (ISS)" were applied. Mean ± standard deviation, frequency, and percentage values, Kruskal Wallis, Mann Whitney-U test, and Spearman correlation analysis were used in the data analysis. The statistical significance level was accepted as p<0.05.

Results: It was found that 65.2% of the nurses had no desire to care for migrant or refugee patients, 87.9% had difficulties while giving care, and 96.2% were found to be hindered by language differences while caring for patients. The mean total score of the ISS scale was determined as 61.58±9.96. When the ISS scale was evaluated in terms of the total score, the mean scores of those aged >30 years (p=0.021), those with undergraduate and graduate degrees (p=0.036), and those living in the city center were high (p=0.044). While the scale's total score was higher in those who benefited from the media and previous experiences as a source of cultural information (p=0.015, p=0.002, respectively), it was lower in those who had difficulties caring for immigrants and refugee patients (p=0.035).

Conclusion: In our result, it is seen that the level of intercultural sensitivity in nurses is moderate, and age, education level, and place of residence for immigrant or refugee patients affect intercultural sensitivity. It is seen that nurses with low intercultural sensitivity have difficulties in giving care to immigrant and refugee patients.
‘Is the Fear of Coronavirus Bigger than the Reality Of Coronavirus?’ The Relationship of the Level of Depression and Social Support of the Postpartum Women with the Fear of COVID-19
Authors: UZUNKAYA ÖZTOPRAK Pınar , CALPBİNİCİ Pelin , AKBAY KISA Ayşe Sevim
Published: May 2023

Objective: This study has been carried out aiming to determine the correlation between the fear of COVID-19 experienced by women in the postpartum period and the postpartum depression and the level of perceived social support, and the factors affecting the fear of COVID-19.

Methods: The data of this cross-sectional and correlation-seeking study was collected through an online questionnaire conducted between February and April 2021. The introductory information form, the Fear of COVID-19 Scale (FCV-19S), Edinburgh Postpartum Depression Scale (EPDS) and Multidimensional Scale of Perceived Social Support (MSPSS) were used for data collection in the study. Continuous variables were reported as mean±standard deviation and categorical variables were reported as numbers and percentages (%).

Results: It has been determined in the study that 65.1% of women experienced the fear of COVID-19 in high level. A statistically significant difference has been found between the women's age, education level, and their fear of their infants being infected with the coronavirus and the fear of COVID-19 (p<0.05). It has been discovered that as women's fear of COVID-19 increases, so does the risk of postpartum depression.

Conclusion: It becomes more of an issue to monitor the level of the fear of coronavirus and postpartum depression and to plan appropriate interventions for the purpose of protecting and maintaining maternal health during the pandemic process.
The Evaluation of the Relation Between Smartphone Addiction and Eating Attitudes among Medical Students
Authors: ÇAKIR KARDEŞ Vildan , ÇÖLGEÇEN Ali Deniz , ÇETİN Hande , ÖNDER Selin , ÇIRAK Bensu Şengül , TENK Sudenur , KICIMAN Murtaza Zülfikar , KART Büşra , ÖZTÜRK Sait , TAP Durmuş Ali , AKBABA Yusuf Aşır , ALFARİS Abdul Rahman , ABU HAMED Ahmad , ALHASAN İslam
Published: May 2023

Objective: This study aims to evaluate the relationship between smartphone addiction and demographical characteristics, eating attitudes, and body mass index of medical students.

Methods: The data was obtained through personal questionnaires, the scales regarding eating attitudes and smartphone addiction. The questionnaire and the scales were carried out online among current medical students of Zonguldak Bülent Ecevit University.

Results: Of the participants (n=347), 59.9% were female,40.1% were male. Participants were found to use internet mostly through their smartphones and they were also found to use their smartphones mostly for messaging and monitoring social media. The scores for the Smartphone Addiction Scale were found to be significantly higher in students who were using their smartphones for social media than those who were not. A weak, positive, and significant relationship was found between the scores of the Smartphone Addiction Scale and Eating Attitudes Test of the students (r=0.135,p=0.12). As a result of the correlation analysis, a very weak, positive and significant relationship was found between Body Mass Index and the age of owning the first smartphone (r=0.113, p=0.036).

Conclusion: We reported a relation between the intentions of using a smartphone and smartphone addiction and another relation between one’s age of owning the first smartphone and these individuals’ body mass indexes. A difference was observed between those who have abnormal eating attitudes and who have not regarding smartphone addiction scale scores.
Amoebicidal and Cytotoxic Activity of Propolis collected from Different Regions in Turkey on Acanthamoeba castellanii Trophozoites
Authors: KOLOREN Zeynep , ERTÜRK Ömer , ATLI ŞEKEROĞLU Zülal , KARAMAN Ülkü
Published: May 2023

Objective: The present study aimed to investigate the amoebicidal effects of propolis collected from different regions in Turkey on Acanthamoeba trophozoites.

Method: The propolis was collected from different geographic sites (Van, Erzurum, Gümüşhane, Ordu, Rize, and Muğla) in Turkey. Different concentrations of propolis ethanolic extract (in quantities from 1, 2, 3, 4, 5, 6, 7, and 8 mg/mL) and the same volume of trophozoites in 100 μl culture were blended for the identification of the amoebicidal efficiency of propolis.

Results: The growth of trophozoites stopped in Turkish propolis extracts with 50% inhibitory concentrations (IC50)/48h for 5 mg/mL extract solution. Propolis showed more potent inhibitory effects on Acanthamoeba trophozoites at concentrations of 7, 6, 5, 4, and 3 mg/mL for 72 h. Propolis extract substantially inhibited human bronchial epithelial cells, especially at higher concentrations (7, 8, and 16 mg/mL).
Propolis can kill Acanthamoeba trophozoites at a concentration (of 3-6 mg/mL) but is safe for human bronchial epithelial cells at the same concentrations after 72 h treatment, this paves the way for propolis to be an alternative source of therapeutic drugs in the treatment of Acanthamoeba spp.

Conclusion: Acanthamoeba infection still cannot be treated with drugs. In this study, propolis collected from different regions of Turkey showed amoebic and cytotoxic activities. Propolis extract, which is a natural product that can be used against Acanthamoeba trophozoites can be an alternative source of therapeutic drugs in the treatment of Acanthamoeba, supported by in vivo studies.
Examination the Relationship Between Parents' Attitudes and Beliefs about Human Papilloma Virus Vaccine and Health Literacy
Authors: TOPKARA Nilüfer , DAĞLI Elif
Published: May 2023

Objective: This study was conducted to examine the relationship between the attitudes and beliefs of parents about Human papillomavirus vaccine and their health literacy.

Methods: The sample of this descriptive and cross-sectional study consisted of 599 parents who volunteered to participate in the study and had access to our survey sent from the parent whatsapp groups of a secondary school located in rural areas in the central region of Türkiye. A Descriptive Information Form, the Carolina HPV Vaccination Attitudes and Beliefs Scale, and Turkey Health Literacy Scale-32 were used to collect research data.

Results: The mean age of 56.8% (n: 340) of the parents was ≥ 45 years, 68.4% (n:410) were women, 49.6% (n:297) had primary education, 92.0% (n:551) did not have a history of cervical cancer in their mothers, 89.8% (n:538) did not have a history of cervical cancer in their family, 92.2% (n:552) had not had their children vaccinated against HPV. Also, 28.4% (n= 170) of the participants had received information about the HPV vaccine from health personnel. It was determined that the risk of not having the child vaccinated was 1.320 times higher in participants with an equal income and expenses than in those whose income was higher than their expenses and that it was 4.514 times higher in participants with no family history of cervical cancer than in those with a history of this cancer type.

Conclusion: In the study, it was concluded that those whose income was equal to their expenses and those who did not have a family history of cervical cancer had a higher risk of not having their child vaccinated and that the high level of health literacy of the parents positively affected their attitudes and beliefs about human papilloma virus vaccination. As the parents' level of health literacy increased, the rate of getting their children vaccinated against HPV increased significantly. Considering this situation, it is thought that knowledge of vaccines can be increased, attitudes and beliefs can be improved, and vaccination rates can be increased by targeting health literacy in the interventions to be implemented.
Recent advances in heavily doped plasmonic copper chalcogenides: from synthesis to biological application
Authors: Mao Qiulian , Ma Jicun , Chen Mei , Lin Shiying , Razzaq Noman , Cui Jiabin
Published: May 2023

Copper-based chalcogenide compounds have emerged as alternative materials to Cd- or Pb-based traditional semiconductors and have drawn significant attention. Compared with widely reported semiconductors, copper chalcogenide nanocrystals (NCs) with abundant copper defects and vacancies present p-type features. Additionally, the migration of free hole carriers in copper-based chalcogenide NCs produced a metal-like local surface plasmon resonance (LSPR) effect. In this review, we focused on the plasmonic copper chalcogenide NCs achieved through a heavily doped strategy. The copper sulfur compounds with versatile atomic ratios and complex crystal structures exhibit rich electrical, optical, and magnetic properties, making them highly promising for a broad range of applications, from energy conversion to biomedical fields. Therefore, our main focus is on the classification of copper chalcogenide synthesis strategies, theoretical studies of doping, doping strategies, and biological applications. We aim to analyze the trends of copper-based chalcogenide nanomaterials for clinical applications by summarizing previous studies and presenting designs and concepts in a brief manner.