bluuebunny/crossref_metadata_2025 huggingface dataset:
Preparation of Polyacrylate Hollow Microspheres via Facile Spray Drying
Authors: Chen Pingxu , Ye Nanbiao , He Chaoxiong , Tang Lei , Li Shuliang , Sun Luyi , Li Yuntao
Published: January 2019

Polyacrylate microspheres with a hollow structure were prepared by a facile spray drying method. The effects of spray drying process parameters, including inlet temperature, atomizer rotational speed, and feed speed, on the particle size, bulk density, and morphology of the resultant polyacrylate hollow microspheres were investigated and discussed. The mechanism for the formation of the polyacrylate hollow microspheres was proposed. This facile and scalable method for preparing hollow polymer microspheres is expected to be valuable to prepare various polymer hollow structures for widespread application.
Arabic Cursive Text Recognition from Natural Scene Images
Authors: Ahmed Saad Bin , Naz Saeeda , Razzak Muhammad Imran , Yusof Rubiyah
Published: January 2019

This paper presents a comprehensive survey on Arabic cursive scene text recognition. The recent years’ publications in this field have witnessed the interest shift of document image analysis researchers from recognition of optical characters to recognition of characters appearing in natural images. Scene text recognition is a challenging problem due to the text having variations in font styles, size, alignment, orientation, reflection, illumination change, blurriness and complex background. Among cursive scripts, Arabic scene text recognition is contemplated as a more challenging problem due to joined writing, same character variations, a large number of ligatures, the number of baselines, etc. Surveys on the Latin and Chinese script-based scene text recognition system can be found, but the Arabic like scene text recognition problem is yet to be addressed in detail. In this manuscript, a description is provided to highlight some of the latest techniques presented for text classification. The presented techniques following a deep learning architecture are equally suitable for the development of Arabic cursive scene text recognition systems. The issues pertaining to text localization and feature extraction are also presented. Moreover, this article emphasizes the importance of having benchmark cursive scene text dataset. Based on the discussion, future directions are outlined, some of which may provide insight about cursive scene text to researchers.
Building an Effective Intrusion Detection System Using the Modified Density Peak Clustering Algorithm and Deep Belief Networks
Authors: Yang Yanqing , Zheng Kangfeng , Wu Chunhua , Niu Xinxin , Yang Yixian
Published: January 2019

Machine learning plays an important role in building intrusion detection systems. However, with the increase of data capacity and data dimension, the ability of shallow machine learning is becoming more limited. In this paper, we propose a fuzzy aggregation approach using the modified density peak clustering algorithm (MDPCA) and deep belief networks (DBNs). To reduce the size of the training set and the imbalance of the samples, MDPCA is used to divide the training set into several subsets with similar sets of attributes. Each subset is used to train its own sub-DBNs classifier. These sub-DBN classifiers can learn and explore high-level abstract features, automatically reduce data dimensions, and perform classification well. According to the nearest neighbor criterion, the fuzzy membership weights of each test sample in each sub-DBNs classifier are calculated. The output of all sub-DBNs classifiers is aggregated based on fuzzy membership weights. Experimental results on the NSL-KDD and UNSW-NB15 datasets show that our proposed model has higher overall accuracy, recall, precision and F1-score than other well-known classification methods. Furthermore, the proposed model achieves better performance in terms of accuracy, detection rate and false positive rate compared to the state-of-the-art intrusion detection methods.
Cross-Method-Based Analysis and Classification of Malicious Behavior by API Calls Extraction
Authors: Ndibanje Bruce , Kim Ki Hwan , Kang Young Jin , Kim Hyun Ho , Kim Tae Yong , Lee Hoon Jae
Published: January 2019

Data-driven public security networking and computer systems are always under threat from malicious codes known as malware; therefore, a large amount of research and development is taking place to find effective countermeasures. These countermeasures are mainly based on dynamic and statistical analysis. Because of the obfuscation techniques used by the malware authors, security researchers and the anti-virus industry are facing a colossal issue regarding the extraction of hidden payloads within packed executable extraction. Based on this understanding, we first propose a method to de-obfuscate and unpack the malware samples. Additional, cross-method-based big data analysis to dynamically and statistically extract features from malware has been proposed. The Application Programming Interface (API) call sequences that reflect the malware behavior of its code have been used to detect behavior such as network traffic, modifying a file, writing to stderr or stdout, modifying a registry value, creating a process. Furthermore, we include a similarity analysis and machine learning algorithms to profile and classify malware behaviors. The experimental results of the proposed method show that malware detection accuracy is very useful to discover potential threats and can help the decision-maker to deploy appropriate countermeasures.
Predictions of Ship Extreme Hydroelastic Load Responses in Harsh Irregular Waves and Hull Girder Ultimate Strength Assessment
Authors: Jiao Jialong , Jiang Yong , Zhang Hao , Li Chengjun , Chen Chaohe
Published: January 2019

In this paper, the hydroelastic motion and load responses of a large flexible ship sailing in irregular seaways are predicted and the hull girder ultimate strength is subsequently evaluated. A three-dimensional time-domain nonlinear hydroelasticity theory is developed where the included nonlinearities are those arising from incident wave force, hydrostatic restoring force and slamming loads. The hull girder structure is simplified as a slender Timoshenko beam and fully coupled with the hydrodynamic model in a time domain. Segmented model towing-tank tests are then conducted to validate the proposed hydroelasticity theory. In addition, short-term and long-term predictions of ship responses in irregular seaways are conducted with the help of the developed hydroelastic code in order to determine the extreme design loads. Finally, a simplified strength-check equation is proposed, which will provide significant reference and convenience for ship design and evaluation. The hull girder ultimate strength is assessed by both the improved Rule approach and direct calculation.
Genome Size Unaffected by Variation in Morphological Traits, Temperature, and Precipitation in Turnip
Authors: Basak Supriyo , Sun Xudong , Wang Guangyan , Yang Yongping
Published: January 2019

Genome size (GS) was proposed as proxy for gross phenotypic and environmental changes in plants. GS organismal complexity is an enigma in evolutionary biology. While studies pertaining to intraspecific GS variation are abundant, literatures reporting the adaptive significance of GS are largelymissing. During food shortage, Brassica rapa var. rapa (turnip) is used as food and fodder for sustaining the livelihood of residents in the Qinghai Tibetan Plateau (QTP), which is also known as “the roof of the world”. Thus, climatic extremities make this region a natural environment to test adaptive significance of GS variation in turnip landraces. Therefore, from the QTP and its adjacent regions (the Hengduanshan and the Himalayas), we investigated adaptive evolution of GS in turnip landraces. Tuber diameter of turnip landraces was found to be significantly correlated with most of the environmental factors. GS was also shown not to be associated with morphological traits, temperature, and precipitation. Moreover, principal component analyses based on the whole dataset trisected the landraces into three distinct populations based on landrace usage—Hengduanshan, QTP, and the Himalayas. Nonetheless, our cumulative dataset showed evidence of adaptation of turnip landrace to different environments throughnonassociated genomic and phenomic plasticity.
Acknowledgement to Reviewers of Arts in 2018
Authors:   Arts Editorial Office
Published: January 2019

Rigorous peer-review is the corner-stone of high-quality academic publishing [...]
Stark Widths of Yb III and Lu IV Spectral Lines
Authors: Dimitrijević Milan S.
Published: January 2019

Rare Earth Elements are important for stellar atmosphere analysis but the corresponding Stark broadening data are scarce. For Yb III and Lu IV theoretical as well as experimental data on Stark broadening parameters of spectral lines are absent in the literature. Using the modified semiempirical method of Dimitrijević and Konjević, we determined Stark widths for four Yb III and four Lu IV transitions, belonging to the erbium isoelectronic sequence. The obtained results are also used to discuss similarities between homologous transitions in the erbium isoelectronic sequence. We note as well that calculated widths will be implemented in the STARK-B database which is also a part of the Virtual Atomic and Molecular Data Center.
Versatility of Cyclophilins in Plant Growth and Survival: A Case Study in Arabidopsis
Authors: Barbosa dos Santos Izailda , Park Sang-Wook
Published: January 2019

Cyclophilins (CYPs) belong to a peptidyl-prolyl cis-trans isomerase family, and were first characterized in mammals as a target of an immunosuppressive drug, cyclosporin A, preventing proinflammatory cytokine production. In Arabidopsis, 29 CYPs and CYP-like proteins are found across all subcellular compartments, involved in various physiological processes including transcriptional regulation, organogenesis, photosynthetic and hormone signaling pathways, stress adaptation and defense responses. These important but diverse activities of CYPs must be reflected by their versatility as cellular and molecular modulators. However, our current knowledge regarding their mode of actions is still far from complete. This review will briefly revisit recent progresses on the roles and mechanisms of CYPs in Arabidopsis studies, and information gaps within, which help understanding the phenotypic and environmental plasticity of plants.
Doxorubicin Is Key for the Cardiotoxicity of FAC (5-Fluorouracil + Adriamycin + Cyclophosphamide) Combination in Differentiated H9c2 Cells
Authors: Pereira-Oliveira Maria , Reis-Mendes Ana , Carvalho Félix , Remião Fernando , Bastos Maria de Lourdes , Costa Vera Marisa
Published: January 2019

Currently, a common therapeutic approach in cancer treatment encompasses a drug combination to attain an overall better efficacy. Unfortunately, it leads to a higher incidence of severe side effects, namely cardiotoxicity. This work aimed to assess the cytotoxicity of doxorubicin (DOX, also known as Adriamycin), 5-fluorouracil (5-FU), cyclophosphamide (CYA), and their combination (5-Fluorouracil + Adriamycin + Cyclophosphamide, FAC) in H9c2 cardiac cells, for a better understanding of the contribution of each drug to FAC-induced cardiotoxicity. Differentiated H9c2 cells were exposed to pharmacological relevant concentrations of DOX (0.13–5 μM), 5-FU (0.13–5 μM), CYA (0.13–5 μM) for 24 or 48 h. Cells were also exposed to FAC mixtures (0.2, 1 or 5 μM of each drug and 50 μM 5-FU + 1 μM DOX + 50 μM CYA). DOX was the most cytotoxic drug, followed by 5-FU and lastly CYA in both cytotoxicity assays (reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) and neutral red (NR) uptake). Concerning the equimolar combination with 1 or 5 μM, FAC caused similar cytotoxicity to DOX alone. Even in the presence of higher concentrations of 5-FU and CYA (50 μM 5-FU + 1 μM DOX + 50 μM CYA), 1 μM DOX was still a determinant for the cardiotoxicity observed in the cytotoxicity assays, phase contrast morphological evaluation, and mitochondrial potential depolarization evaluation. To the best of our knowledge, this was the first in vitro work with this combination regimen, DOX being the most toxic drug and key to the toxicity of FAC.
Combination of Cell-Penetrating Peptides with Nanoparticles for Therapeutic Application: A Review
Authors: Silva Sara , Almeida António , Vale Nuno
Published: January 2019

Cell-penetrating peptides (CPPs), also known as protein translocation domains, membrane translocating sequences or Trojan peptides, are small molecules of 6 to 30 amino acid residues capable of penetrating biological barriers and cellular membranes. Furthermore, CPP have become an alternative strategy to overcome some of the current drug limitations and combat resistant strains since CPPs are capable of delivering different therapeutic molecules against a wide range of diseases. In this review, we address the recent conjugation of CPPs with nanoparticles, which constitutes a new class of delivery vectors with high pharmaceutical potential in a variety of diseases.
The Effect of Arabic Gum on Renal Function in Reversible Unilateral Ureteric Obstruction
Authors: Hammad Fayez T. , Al Salam Suhail , Nemmar Abderrahim , Ali Mahmoud , Lubbad Loay
Published: January 2019

Arabic gum (AG) has antioxidant and anti-inflammatory properties. However, the effect of AG in ureteric obstruction (UO) has not been investigated yet. Male rats underwent reversible left unilateral UO (UUO) for 72 h. Group AG-1 (n = 12) received AG 15 g/kg/day dissolved in drinking water starting seven days before and continuing throughout the period of the UUO, whereas group Vx-1 (n = 8) had only water. Group AG-2 (n = 12) and Vx-2 (n = 8) had similar protocols as AG-1 and Vx-1, respectively, but underwent terminal experiments to measure renal functions, six days post-UUO reversal. Arabic gum significantly attenuated the UUO-induced increase in the tissue level of malonedialdehyde and superoxide dismutase and the rise in the gene expression of TNF-α, TGF-β1, and p53 in AG-1 compared to Vx-1. It also attenuated the severity of tubular dilatation. However, AG did not affect the alterations in the renal blood flow or glomerular filtration rate. The fractional sodium excretion was lower in AG-2 but did not reach statistical significance (0.40 ± 0.11 vs 0.74 ± 0.12, p = 0.07). AG attenuated the UUO-induced rise in oxidative stress markers and proinflammatory and profibrotic cytokines and the degree of renal tubular dilatation, indicating a protective effect in obstructive nephropathy.
Convenient Preparation of Graphene Oxide from Expandable Graphite and Its Characterization by Positron Annihilation Lifetime Spectroscopy
Authors: Panzarasa Guido , Consolati Giovanni , Scavini Marco , Longhi Mariangela , Quasso Fiorenza
Published: January 2019

Graphene oxide (GO) is conveniently prepared from expandable graphite using a simplified Hummers’ method. The product is thoroughly characterized by usual techniques (UV-vis, Fourier-transform infrared (FTIR) and Raman spectroscopies, zeta potential, electron microscopy, X-ray diffraction, nitrogen adsorption) to confirm the success of synthesis. Positron annihilation lifetime spectroscopy (PALS) is then used to extract information on the microenvironment in between the layers of graphene oxide.
Expression of Neural Crest Markers GLDC and ERRFI1 is Correlated with Melanoma Prognosis
Authors: Jäger Katharina , Larribère Lionel , Wu Huizi , Weiss Christel , Gebhardt Christoffer , Utikal Jochen
Published: January 2019

Regulation of particular genes during the formation of neural crest (NC) cells is also described during progression of malignant melanoma. In this context, it is of paramount importance to develop neural crest models allowing the identification of candidate genes, which could be used as biomarkers for melanoma prognosis. Here, we used a human induced Pluripotent Stem Cells (iPSC)-based approach to present novel NC-associated genes, expression of which was upregulated in melanoma. A list of 8 candidate genes, based on highest upregulation, was tested for prognostic value in a tissue microarray analysis containing samples from advanced melanoma (good versus bad prognosis) as well as from high-risk primary melanomas (early metastasizing versus non or late-metastasizing). CD271, GLDC, and ERRFI1 showed significantly higher expression in metastatic patients who died early than the ones who survived at least 30 months. In addition, GLDC and TWIST showed a significantly higher immunohistochemistry (IHC) score in primary melanomas from patients who developed metastases within 12 months versus those who did not develop metastases in 30 months. In conclusion, our iPSC-based study reveals a significant association of NC marker GLDC protein expression with melanoma prognosis.
The Efficacy and Safety of (Neo)Adjuvant Therapy for Gastric Cancer: A Network Meta-analysis
Authors: van den Ende Tom , ter Veer Emil , Machiels Mélanie , Mali Rosa M. A. , Abe Nijenhuis Frank A. , de Waal Laura , Laarman Marety , Gisbertz Suzanne S. , Hulshof Maarten C. C. M. , van Oijen Martijn G. H. , van Laarhoven Hanneke W. M.
Published: January 2019

Background: Alternatives in treatment-strategies exist for resectable gastric cancer. Our aims were: (1) to assess the benefit of perioperative, neoadjuvant and adjuvant treatment-strategies and (2) to determine the optimal adjuvant regimen for gastric cancer treated with curative intent. Methods: PubMed, EMBASE, CENTRAL, and ASCO/ESMO conferences were searched up to August 2017 for randomized-controlled-trials on the curative treatment of resectable gastric cancer. We performed two network-meta-analyses (NMA). NMA-1 compared perioperative, neoadjuvant and adjuvant strategies only if there was a direct comparison. NMA-2 compared different adjuvant chemo(radio)therapy regimens, after curative resection. Overall-survival (OS) and disease-free-survival (DFS) were analyzed using random-effects NMA on the hazard ratio (HR)-scale and calculated as combined HRs and 95% credible intervals (95% CrIs). Results: NMA-1 consisted of 9 direct comparisons between strategies for OS (14 studies, n = 4187 patients). NMA-2 consisted of 16 direct comparisons between adjuvant chemotherapy/chemoradiotherapy regimens for OS (37 studies, n = 10,761) and 14 for DFS (30 studies, n = 9714 patients). Compared to taxane-based-perioperative-chemotherapy, surgery-alone (HR = 0.58, 95% CrI = 0.38–0.91) and perioperative-chemotherapy regimens without a taxane (HR = 0.79, 95% CrI = 0.58–1.15) were inferior in OS. After curative-resection, the doublet oxaliplatin-fluoropyrimidine (for one-year) was the most efficacious adjuvant regimen in OS (HR = 0.47, 95% CrI = 0.28–0.80). Conclusions: For resectable gastric cancer, (1) taxane-based perioperative-chemotherapy was the most promising treatment strategy; and (2) adjuvant oxaliplatin-fluoropyrimidine was the most promising regimen after curative resection. More research is warranted to confirm or reproach these findings.
Very Long-Chain C24:1 Ceramide Is Increased in Serum Extracellular Vesicles with Aging and Can Induce Senescence in Bone-Derived Mesenchymal Stem Cells
Authors: Khayrullin Andrew , Krishnan Priyanka , Martinez-Nater Luis , Mendhe Bharati , Fulzele Sadanand , Liu Yutao , Mattison Julie A. , Hamrick Mark W.
Published: January 2019

Extracellular vesicles (EVs), including exosomes and microvesicles, function in cell-to-cell communication through delivery of proteins, lipids and microRNAs to target cells via endocytosis and membrane fusion. These vesicles are enriched in ceramide, a sphingolipid associated with the promotion of cell senescence and apoptosis. We investigated the ceramide profile of serum exosomes from young (24–40 yrs.) and older (75–90 yrs.) women and young (6–10 yrs.) and older (25–30 yrs.) rhesus macaques to define the role of circulating ceramides in the aging process. EVs were isolated using size-exclusion chromatography. Proteomic analysis was used to validate known exosome markers from Exocarta and nanoparticle tracking analysis used to characterize particle size and concentration. Specific ceramide species were identified with lipidomic analysis. Results show a significant increase in the average amount of C24:1 ceramide in EVs from older women (15.4 pmol/sample) compared to those from younger women (3.8 pmol/sample). Results were similar in non-human primate serum samples with increased amounts of C24:1 ceramide (9.3 pmol/sample) in older monkeys compared to the younger monkeys (1.8 pmol/sample). In vitro studies showed that primary bone-derived mesenchymal stem cells (BMSCs) readily endocytose serum EVs, and serum EVs loaded with C24:1 ceramide can induce BMSC senescence. Elevated ceramide levels have been associated with poor cardiovascular health and memory impairment in older adults. Our data suggest that circulating EVs carrying C24:1 ceramide may contribute directly to cell non-autonomous aging.
Expanding the miRNA Repertoire in Atlantic Salmon; Discovery of IsomiRs and miRNAs Highly Expressed in Different Tissues and Developmental Stages
Authors: Woldemariam Nardos Tesfaye , Agafonov Oleg , Høyheim Bjørn , Houston Ross D. , Taggart John B. , Andreassen Rune
Published: January 2019

MicroRNAs (miRNAs) are important post-transcriptional gene expression regulators. Here, 448 different miRNA genes, including 17 novel miRNAs, encoding for 589 mature Atlantic salmon miRNAs were identified after sequencing 111 samples (fry, pathogen challenged fry, various developmental and adult tissues). This increased the reference miRNAome with almost one hundred genes. Prior to isomiR characterization (mature miRNA variants), the proportion of erroneous sequence variants (ESVs) arising in the analysis pipeline was assessed. The ESVs were biased towards 5’ and 3’ end of reads in unexpectedly high proportions indicating that measurements of ESVs rather than Phred score should be used to avoid misinterpreting ESVs as isomiRs. Forty-three isomiRs were subsequently discovered. The biological effect of the isomiRs measured as increases in target diversity was small (<3%). Five miRNA genes showed allelic variation that had a large impact on target gene diversity if present in the seed. Twenty-one miRNAs were ubiquitously expressed while 31 miRNAs showed predominant expression in one or few tissues, indicating housekeeping or tissue specific functions, respectively. The miR-10 family, known to target Hox genes, were highly expressed in the developmental stages. The proportion of miR-430 family members, participating in maternal RNA clearance, was high at the earliest developmental stage.
Acknowledgement to Reviewers of Challenges in 2018
Authors:   Challenges Editorial Office
Published: January 2019

Rigorous peer-review is the corner-stone of high-quality academic publishing [...]
Acknowledgement to Reviewers of Climate in 2018
Authors:   Climate Editorial Office
Published: January 2019

Rigorous peer-review is the corner-stone of high-quality academic publishing [...]
Dust Devils: Structural Features, Dynamics and Climate Impact
Authors: Onishchenko Oleg , Fedun Viktor , Horton Wendell , Pokhotelov Oleg , Verth Gary
Published: January 2019

According to modern concepts, the main natural sources of dust in the atmosphere are dust storms and associated dust devils—rotating columns of rising dust. The impact of dust and aerosols on climate change in the past, present and future is one of the poorly understood and, at the same time, one of the fundamental elements needed for weather and climate forecasting. The purpose of this review is to describe and summarise the results of the study of dust devils in the Earth’s atmosphere. Special attention is given to the description of the 3D structures, the external flows and atmospheric gradients of temperature that lead to the generation and maintenance of the dust devils.
Effect of Synthesis Conditions on the Controlled Growth of MgAl–LDH Corrosion Resistance Film: Structure and Corrosion Resistance Properties
Authors: Iqbal Muhammad Ahsan , Fedel Michele
Published: January 2019

In this study, a series of MgAl–layered double hydroxide (LDH) thin films were synthesized by a single step hydrothermal process at different synthetic conditions on AA6082, and the combined effect of reaction temperatures and crystallization times on in situ growth MgAl–LDH structural geometry, growth rate, and more importantly on the corresponding corrosive resistance properties are briefly discussed. The synthesis of LDH was performed at reaction temperatures of 40, 60, 80, and 100 °C, while the treatment time was varied at 12, 18, and 24 h. The as-prepared synthetic coatings were characterized by scanning electron microscopy (SEM), energy dispersion spectroscopy (EDS), X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FT-IR), while the corresponding corrosion protection efficiency of the developed coating was studied through potentiodynamic polarization studies and electrochemical impedance spectra. The findings demonstrated that extended crystallization time and reaction temperature impart a significant effect on the oriented growth of layered double hydroxide, the surface morphology, and on the film thickness, which had a remarkable influence on the LDH corrosion resistance ability. The LDH coated specimen developed at 100 °C for 18 h reaction time showed a more compact and dense structure compared to the traditional platelet structure obtained at 80 °C for 24 h crystallization time, and interestingly that compact structure exhibited the lowest corrosion current density, up to five orders of magnitude lower than that of bare AA6082.
Acknowledgement to Reviewers of Computation in 2018
Authors:   Computation Editorial Office
Published: January 2019

Rigorous peer-review is the corner-stone of high-quality academic publishing [...]
Hidden Link Prediction in Criminal Networks Using the Deep Reinforcement Learning Technique
Authors: Lim Marcus , Abdullah Azween , Jhanjhi NZ , Supramaniam Mahadevan
Published: January 2019

Criminal network activities, which are usually secret and stealthy, present certain difficulties in conducting criminal network analysis (CNA) because of the lack of complete datasets. The collection of criminal activities data in these networks tends to be incomplete and inconsistent, which is reflected structurally in the criminal network in the form of missing nodes (actors) and links (relationships). Criminal networks are commonly analyzed using social network analysis (SNA) models. Most machine learning techniques that rely on the metrics of SNA models in the development of hidden or missing link prediction models utilize supervised learning. However, supervised learning usually requires the availability of a large dataset to train the link prediction model in order to achieve an optimum performance level. Therefore, this research is conducted to explore the application of deep reinforcement learning (DRL) in developing a criminal network hidden links prediction model from the reconstruction of a corrupted criminal network dataset. The experiment conducted on the model indicates that the dataset generated by the DRL model through self-play or self-simulation can be used to train the link prediction model. The DRL link prediction model exhibits a better performance than a conventional supervised machine learning technique, such as the gradient boosting machine (GBM) trained with a relatively smaller domain dataset.
Improved Single-Crystal Growth of Sr2RuO4
Authors: Bobowski Jake S. , Kikugawa Naoki , Miyoshi Takuto , Suwa Haruki , Xu Han-shu , Yonezawa Shingo , Sokolov Dmitry A. , Mackenzie Andrew P. , Maeno Yoshiteru
Published: January 2019

High-quality single crystals are essentially needed for the investigation of the novel bulk properties of unconventional superconductors. The availability of such crystals grown by the floating-zone method has helped to unveil the unconventional superconductivity of the layered perovskite Sr2RuO4, which is considered as a strong candidate of a topological spin-triplet superconductor. Yet, recent progress of investigations urges further efforts to obtain ultimately high-quality crystalline samples. In this paper, we focus on the method of preparation of feed rods for the floating-zone melting and report on the improvements of the crystal growth. We present details of the improved methods used to obtain crystals with superconducting transition temperatures Tc that are consistently as high as 1.4 K, as well as the properties of these crystals.
Polarization Analysis in Mössbauer Reflectometry with Synchrotron Mössbauer Source
Authors: Andreeva Marina , Baulin Roman , Chumakov Aleksandr , Kiseleva Tatiyana , Rüffer Rudolf
Published: January 2019

Polarization selection of the reflected radiation has been employed in Mössbauer reflectivity measurements with a synchrotron Mössbauer source (SMS). The polarization of resonantly scattered radiation differs from the polarization of an incident wave so the Mössbauer reflectivity contains a scattering component with 90° rotated polarization relative to the π-polarization of the SMS for some hyperfine transitions. We have shown that the selection of this rotated π→σ component from total reflectivity gives an unusual angular dependence of reflectivity characterized by a peak near the critical angle of the total external reflection. In the case of collinear antiferromagnetic interlayer ordering, the “magnetic” maxima on the reflectivity angular curve are formed practically only by radiation with this rotated polarization. The first experiment on Mössbauer reflectivity with a selection of the rotated polarization discovers the predicted peak near the critical angle. The measurement of the rotated π→σ polarization component in Mössbauer reflectivity spectra excludes the interference with non-resonant electronic scattering and simplifies the spectrum shape near the critical angle allowing for an improved data interpretation in the case of poorly resolved spectra. It is shown that the selected component of Mössbauer reflectivity with rotated polarization is characterized by enhanced surface sensitivity, determined by the “squared standing waves” depth dependence. Therefore, the new approach has interesting perspectives for investigations of surfaces, ultrathin layers and multilayers having complicated magnetic structures.
Substituted Azolium Disposition: Examining the Effects of Alkyl Placement on Thermal Properties
Authors: Goossens Karel , Rakers Lena , Shin Tae Joo , Honeker Roman , Bielawski Christopher W. , Glorius Frank
Published: January 2019

We describe the thermal phase characteristics of a series of 4,5-bis(n-alkyl)azolium salts that were studied using thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), polarized-light optical microscopy (POM), and synchrotron-based small- to wide-angle X-ray scattering (SWAXS) measurements. Key results were obtained for 1,3-dimethyl-4,5-bis(n-undecyl)imidazolium iodide (1-11), 1,3-dimethyl-4,5-bis(n-pentadecyl)imidazolium iodide (1-15), and 1,2,3-trimethyl-4,5-bis(n-pentadecyl)imidazolium iodide (2), which were found to adopt enantiotropic smectic A mesophases. Liquid-crystalline mesophases were not observed for 1,3-dimethyl-4,5-bis(n-heptyl)imidazolium iodide (1-7), 3-methyl-4,5-bis(n-pentadecyl)thiazolium iodide (3), and 2-amino-4,5-bis(n-pentadecyl)imidazolium chloride (4). Installing substituents in the 4- and 5-positions of the imidazolium salts appears to increase melting points while lowering clearing points when compared to data reported for 1,3-disubstituted analogues.
Spatiotemporal Analysis of Urban Mobility Using Aggregate Mobile Phone Derived Presence and Demographic Data: A Case Study in the City of Rome, Italy
Authors: Gariazzo Claudio , Pelliccioni Armando , Bogliolo Maria Paola
Published: January 2019

Urban mobility is known to have a relevant impact on work related car accidents especially during commuting. It is characterized by highly dynamic spatial–temporal variability. There are open questions about the size of this phenomenon; its spatial, temporal, and demographic characteristics; and driving mechanisms. A case study is here presented for the city of Rome, Italy. High-resolution population presence and demographic data, derived from mobile phone traffic, were used. Hourly profiles of a defined mobility factor (NPM) were calculated for a gridded domain during working days and cluster analyzed to obtain mean diurnal NPM mobility patterns. Age distributions of the population were calculated from demographic data to get insight in the type of population involved in mobility, and spatially linked with the mobility patterns. Census data about production units and their employees were related with the classified NPM mobility patterns. Seven different NPM mobility patterns were identified and mapped over the study area. The mobility slightly deviates from the census-based demography (0.15 on average, in a range of 0 to 1). The number of employees per 100 inhabitants was found to be the main driving mechanism of mobility. Finally, contributions of people employed in different economic macrocategories were assigned to each mobility time-pattern. Results provide a deeper knowledge of urban dynamics and their driving mechanisms in Rome.
Designing Flexibility and Adaptability: The Answer to Integrated Residential Building Retrofit
Authors: Scuderi Giuliana
Published: January 2019

Speaking about building retrofit in Europe, the attention is often focused on the residential building stock built after the Second World War, which represents the 75% of the total number of buildings present on the territory. Recently many cities are encouraging campaigns of retrofit of the housing heritage built after the Second World War, since, in terms of cost, time, financing, consumption, and sustainability, the practice appears more convenient than building anew. To maximize the benefits of these retrofit campaigns, it is essential to promote multi-purpose and innovative strategies considering contemporarily architectural, functional and structural aspects. In the field of housing, in particular, it is necessary to develop new models able to answer to the new living style of a dynamic society. In fact, today as in the past, one of the downfalls of the housing sector is failing to recognize the human dimension within the designing process. This paper evaluates past architectural practices to achieve adaptability and flexibility in the residential sector and evaluate strategies for integrated retrofit based on two macro-areas: architectural/societal/functional and structural/technological/constructional.
Genotyping of Single Nucleotide Polymorphisms Using Allele-Specific qPCR Producing Amplicons of Small Sizes Directly from Crude Serum Isolated from Capillary Blood by a Hand-Powered Paper Centrifuge
Authors: Barra Gustavo Barcelos , Santa Rita Ticiane Henriques , Jardim Daniella Paniago , Mesquita Pedro Góes , Nobre Camila Santos , Jácomo Rafael Henriques , Abdalla Nery Lídia Freire
Published: January 2019

The cell-free genomic DNA (gDNA) concentration in serum ranges from 1500 to 7500 copies/mL within 2 h after phlebotomy (6–24 times the concentration observed in plasma). Here, we aimed to evaluate the gDNA size distribution in serum with time after coagulation and to test if crude serum can be directly used as a source of gDNA for qPCR. Next, we investigated if single nucleotide polymorphisms (SNPs) could be genotyped directly from the crude serum isolated from capillary blood using a hand-powered paper centrifuge. All tested PCR targets (65, 100, 202 and 688 base pairs) could be successfully amplified from DNA extracted from serum, irrespective of their amplicon size. The observed qPCR quantitation cycles suggested that the genomic DNA yield increased in serum with incubation at room temperature. Additionally, only 65 and 101 base pair qPCR targets could be amplified from crude serum soon after the coagulation. Incubation for 4 days at room temperature was necessary for the amplification of PCR targets of 202 base pairs. The 688 base pair qPCR target could not be amplified from serum directly. Lastly, serum was successfully separated from capillary blood using the proposed paper centrifuge and the genotypes were assigned by testing the crude serum using allele-specific qPCR, producing small amplicon sizes in complete agreement with the genotypes assigned by testing the DNA extracted from whole blood. The serum can be used directly as the template in qPCR for SNP genotyping, especially if small amplicon sizes are applied. This shortcut in the SNP genotyping process could further molecular point-of-care diagnostics due to elimination of the DNA extraction step.
Defining System Requirements for Simplified Blood Culture to Enable Widespread Use in Resource-Limited Settings
Authors: Dailey Peter J. , Osborn Jennifer , Ashley Elizabeth A. , Baron Ellen Jo , Dance David A. B. , Fusco Daniela , Fanello Caterina , Manabe Yukari C. , Mokomane Margaret , Newton Paul N. , Tessema Belay , Isaacs Chris , Dittrich Sabine
Published: January 2019

Bacterial blood stream infections (BSI) are a common cause of mortality and morbidity globally. As the causative agents and the resulting treatment decisions vary, near-patient testing and surveillance tools are necessary to monitor bacterial causes and resistance to antimicrobial agents. The gold standard to identify BSIs is blood culture (BC), a methodology not widely available in resource-limited settings. The aim of the study was to map out a target product profile of a simplified BC system (SBCS) to inform product development efforts. To identify the desired characteristics of a SBCS, we enlisted a small group of specialists working in Africa and Asia. Questions were used to understand challenges and how these constraints inform system requirements. The specialists were infectious disease physicians, public health/clinical microbiologists, clinical researchers, and technology experts with different geographical backgrounds. All suggested that BC should ideally be available at the district hospital level. Many of the same operational challenges, such as limited availability of culture bottles, electricity and internet connectivity, profuse dust, the lack of ambient temperature control, and human capacity constraints were identified across the different regions. BCs, although the accepted gold standard for diagnosis of BSIs, are not widely available outside of reference/research centers in Africa and Asia. To extend the reach of this important tool, it is crucial to engage product developers and academic research partners to develop accessible alternatives.
Acknowledgement to Reviewers of Diseases in 2018
Authors:   Diseases Editorial Office
Published: January 2019

Rigorous peer-review is the corner-stone of high-quality academic publishing [...]
Bacteriophages in Dentistry—State of the Art and Perspectives
Authors: Steier Liviu , De Oliveira Silvia Dias , De Figueiredo José Antonio Poli
Published: January 2019

Bacteriophages, viruses capable of killing bacteria, were discovered in 1915, but the interest in their study has been limited since the advent of antibiotics. Their use in dentistry is still very limited. The authors reviewed studies about bacteriophage structure, mode of action, uses in oral health, and possible future uses in dentistry associated with their possible action over biofilm, as well as the advantages and limitations of phage therapy.
Dynamics and Complexity of a New 4D Chaotic Laser System
Authors: Natiq Hayder , Said Mohamad Rushdan Md , Al-Saidi Nadia M. G. , Kilicman Adem
Published: January 2019

Derived from Lorenz-Haken equations, this paper presents a new 4D chaotic laser system with three equilibria and only two quadratic nonlinearities. Dynamics analysis, including stability of symmetric equilibria and the existence of coexisting multiple Hopf bifurcations on these equilibria, are investigated, and the complex coexisting behaviors of two and three attractors of stable point and chaotic are numerically revealed. Moreover, a conducted research on the complexity of the laser system reveals that the complexity of the system time series can locate and determine the parameters and initial values that show coexisting attractors. To investigate how much a chaotic system with multistability behavior is suitable for cryptographic applications, we generate a pseudo-random number generator (PRNG) based on the complexity results of the laser system. The randomness test results show that the generated PRNG from the multistability regions fail to pass most of the statistical tests.
A New Recurrence-Network-Based Time Series Analysis Approach for Characterizing System Dynamics
Authors: Yang Guangyu , Xu Daolin , Zhang Haicheng
Published: January 2019

In this paper, a novel analysis method based on recurrence networks is proposed to characterize the evolution of dynamical systems. Through phase space reconstruction, a time series was transformed into a high-dimensional recurrence network and a corresponding low-dimensional recurrence network, respectively. Then, two appropriate statistics, the correlation coefficient of node degrees (CCND) and the edge similarity, were proposed to unravel the evolution properties of the considered signal. Through the investigation of the time series with distinct dynamics, different patterns in the decline rate of the CCND at different network dimensions were observed. Interestingly, an exponential scaling emerged in the CCND analysis for the chaotic time series. Moreover, it was demonstrated that the edge similarity can further characterize dynamical systems and provide detailed information on the studied time series. A method based on the fluctuation of edge similarities for neighboring edge groups was proposed to determine the number of groups that the edges should be partitioned into. Through the analysis of chaotic series corrupted by noise, it was demonstrated that both the CCND and edge similarity derived from different time series are robust under additive noise. Finally, the application of the proposed method to ventricular time series showed its effectiveness in differentiating healthy subjects from ventricular tachycardia (VT) patients.
Precipitation Complexity and its Spatial Difference in the Taihu Lake Basin, China
Authors: Hu Jian , Liu Yong , Sang Yan-Fang
Published: January 2019

Due to the rapid urbanization development, the precipitation variability in the Taihu Lake basin (TLB) in East China has become highly complex over the last decades. However, there is limited understanding of the spatiotemporal variability of precipitation complexity and its relationship with the urbanization development in the region. In this article, by considering the whole urbanization process, we use the SampEn index to investigate the precipitation complexity and its spatial differences in different urbanization areas (old urban area, new urban area and suburbs) in TLB. Results indicate that the precipitation complexity and its changes accord well with the urbanization development process in TLB. Higher urbanization degrees correspond to greater complexity degrees of precipitation. Precipitation in old urban areas shows the greatest complexity compared with that in new urban areas and suburbs, not only for the entire precipitation process but also the precipitation extremes. There is a significant negative correlation between the annual precipitation and its SampEn value, and the same change of precipitation can cause a greater complexity change in old urbanization areas compared with the new urban areas and suburbs. It is noted that the enhanced precipitation complexity in a new urban area during recent decades cannot be ignored facing the expanding urbanization.
Chronicle of a Failure Foretold: 2017 Rector Election at Ghent University
Authors: Pérez-Fernández Raúl , García-Lapresta José Luis , De Baets Bernard
Published: January 2019

After more than half a year of elections (yielding three voting stages and nine voting rounds), the 2017 Rector election at Ghent University (Belgium) resulted in a victory for the duo leading all nine voting rounds, and in a resounding defeat for the electoral system. Significant regulation changes were needed in order to break the institutional deadlock in which Ghent University found itself. In this paper, we follow the timeline of the election and dissect what went wrong in the election planning.
The Political Economy of Abandoned Mine Land Fund Disbursements
Authors: Troyan Jessi , Hall Joshua
Published: January 2019

What factors determine federal spending on environmental goods? Is severity of the hazard the only metric of consideration, or do other factors play a vital role in explaining spending? This paper seeks to answer this question and to identify disbursement patterns within the context of the Abandoned Mine Land Fund (AMLF) program, a fund created as an aspect of the Surface Mining Control and Reclamation Act of 1977. We explore whether political factors, as well as environmental and health factors, have an explanatory role in disbursement of AMLF monies. The political factors examined include environmental interest group influence and legislator preferences and/or pressures to fund sites in their home states or districts. The results found here suggest that there exists a mix of public and private interests present in AMLF disbursement decisions during the overall span of the program, and that political influences have gained strength in the decision-making calculus in response to changes in the funding structure of the AMLF.
Total Factor Productivity of Agricultural Firms in Vietnam and Its Relevant Determinants
Authors: Giang Mai Huong , Xuan Tran Dang , Trung Bui Huy , Que Mai Thanh
Published: January 2019

In Vietnam, agriculture is a key sector that promotes economic growth and poverty reduction. Therefore, improving productivity in agriculture is indispensable to the sustainability of the country. This research examined productivity and its determinants from 420 enterprises operating in agriculture. Productivity was measured as the total factor productivity (TFP) obtained from fixed and random effects models. The determinants of TFP including size and age, share of state and foreign ownership, export, accessibility to Internet and bank loan of firms, controlled for year fixed effects, were analyzed. It was shown that 74.6% companies in the agricultural sector were small in size (< 10 < 200 employees). Although the number of large firms (>300 employees) explained 10.6%, they had a remarkable and positive TFP (38.8%, p < 0.01), while both small and very small (<10, and <200 employees, respectively) had strikingly negative TFP values (−71.3% and −32.1%, respectively, p < 0.01), as compared to the medium sizes (< 200 < 300 employees). It was also revealed that although foreign ownership was only 3.8% on average, it had a notably positive effect on TFP (55.0%, p < 0.01). In contrast, state ownership accounted for 30.7%, but it had a negative influence on TFP (−7.5%). The export contributed a negligible and statistically significant effect to TFP (2.6%), which might be attributed to a limited number of firms (4.5%) having mobility in agricultural export. 73% received a bank loan, and only 18.2% had access to the Internet, but both of them yielded remarkable TFP values (18.5%, p < 0.01 and 3.4%, p < 0.05 respectively). The Hausman test indicated that the fixed effects (FE) model was more effective than the random effects (RE) model to estimate the TFP. The findings of this study suggested that reform efforts should focus on improving the productivity of small agricultural enterprises. In addition, foreign investment, effective use of bank loan and Internet accessibility should be further enhanced. The results of this study may provide insights for policymakers who aim to improve the productivity in agricultural enterprises and thereby contribute to the sustainable growth of the country.