bluuebunny/crossref_metadata_2025 huggingface dataset:
The Okubo–Weiss criterion in hydrodynamic flows: geometric aspects and further extension
Authors: Shivamoggi B K , van Heijst G J F , Kamp L P J
Published: January 2022

The Okubo (1970 Deep Sea Res.
17 445)–Weiss (1991 Physica D 48 273) criterion, has been extensively used as a diagnostic tool to divide a two-dimensional (2D) hydrodynamical flow field into hyperbolic and elliptic regions and to serve as a useful qualitative guide to the complex quantitative criteria. The Okubo–Weiss criterion is frequently validated on empirical grounds by the results ensuing its application. So, we will explore topological implications into the Okubo–Weiss criterion and show the Okubo–Weiss parameter is, to within a positive multiplicative factor, the negative of the Gaussian curvature of the vorticity manifold. The Okubo–Weiss criterion is then reformulated in polar coordinates, and is validated for several examples including the Lamb–Oseen vortex, and the Burgers vortex. These developments are then extended to 2D quasi-geostrophic (QG) flows. The Okubo–Weiss parameter is shown to remain robust under the β-plane approximation to the Coriolis parameter. The Okubo–Weiss criterion is shown to be able to separate the 2D flow-field into coherent elliptic structures and hyperbolic flow configurations very well via numerical simulations of quasi-stationary vortices in QG flows. An Okubo–Weiss type criterion is formulate for 3D axisymmetric slows, and is validated via application to the round Landau–Squire Laminar jet flow.
Can boron form coordination complexes with diffuse electrons? Evidence for linked solvated electron precursors
Authors: Jordan Zachary , Khan Shahriar N , Jackson Benjamin A , Miliordos Evangelos
Published: January 2022

Density functional theory and ab initio multi-reference calculations are performed to examine the stability and electronic structure of boron complexes that host diffuse electrons in their periphery. Such complexes (solvated electron precursors or SEPs) have been experimentally identified and studied theoretically for several s- and d-block metals. For the first time, we demonstrate that a p-block metalloid element can form a stable SEP when appropriate ligands are chosen. We show that three ammonia and one methyl ligands can displace two of the three boron valence electrons to a peripheral 1s-type orbital. The shell model for these outer electrons is identical to previous SEP systems (1s, 1p, 1d, 2s). Further, we preformed the first examination of a molecular system consisting of two SEPs bridged by a hydrocarbon chain. The electronic structure of these dimers is very similar to that of traditional diatomic molecules forming bonding and anti-bonding σ and π orbitals. Their ground state electronic structure resembles that of two He atoms, and our results indicate that the excitation energies are nearly independent of the chain length for four carbon atoms or longer. These findings pave the way for the development of novel materials similar to expanded metals and electrides.
Easy representation of multivariate functions with low-dimensional terms via Gaussian process regression kernel design: applications to machine learning of potential energy surfaces and kinetic energy densities from sparse data
Authors: Manzhos Sergei , Sasaki Eita , Ihara Manabu
Published: January 2022

We show that Gaussian process regression (GPR) allows representing multivariate functions with low-dimensional terms via kernel design. When using a kernel built with high-dimensional model representation (HDMR), one obtains a similar type of representation as the previously proposed HDMR-GPR scheme while being faster and simpler to use. We tested the approach on cases where highly accurate machine learning is required from sparse data by fitting potential energy surfaces and kinetic energy densities.
Assessment of coding-based frailty algorithms for long-term outcome prediction among older people in community settings: a cohort study from the Shizuoka Kokuho Database
Authors: Nishimura Shiori , Kumamaru Hiraku , Shoji Satoshi , Nakatani Eiji , Yamamoto Hiroyuki , Ichihara Nao , Miyachi Yoshiki , Sandhu Alexander T , Heidenreich Paul A , Yamauchi Keita , Watanabe Michiko , Miyata Hiroaki , Kohsaka Shun
Published: January 2022

Objectives

To assess the applicability of Electronic Frailty Index (eFI) and Hospital Frailty Risk Score (HFRS) algorithms to Japanese administrative claims data and to evaluate their association with long-term outcomes.

Study Design and Setting

A cohort study using a regional government administrative healthcare and long-term care (LTC) claims database in Japan 2014–18.

Participants

Plan enrollees aged ≥50 years.

Methods

We applied the two algorithms to the cohort and assessed the scores’ distributions alongside enrollees’ 4-year mortality and initiation of government-supported LTC. Using Cox regression and Fine–Gray models, we evaluated the association between frailty scores and outcomes as well as the models’ discriminatory ability.

Results

Among 827,744 enrollees, 42.8% were categorised by eFI as fit, 31.2% mild, 17.5% moderate and 8.5% severe. For HFRS, 73.0% were low, 24.3% intermediate and 2.7% high risk; 35 of 36 predictors for eFI, and 92 of 109 codes originally used for HFRS were available in the Japanese system. Relative to the lowest frailty group, the highest frailty group had hazard ratios [95% confidence interval (CI)] of 2.09 (1.98–2.21) for mortality and 2.45 (2.28–2.63) for LTC for eFI; those for HFRS were 3.79 (3.56–4.03) and 3.31 (2.87–3.82), respectively. The area under the receiver operating characteristics curves for the unadjusted model at 48 months was 0.68 for death and 0.68 for LTC for eFI, and 0.73 and 0.70, respectively, for HFRS.

Conclusions

The frailty algorithms were applicable to the Japanese system and could contribute to the identifications of enrollees at risk of long-term mortality or LTC use.
Maximum and Time-Dependent Body Mass Index and Breast Cancer Incidence Among Postmenopausal Women in the Black Women’s Health Study
Authors: Gathirua-Mwangi Wambui G , Palmer Julie R , Champion Victoria , Castro-Webb Nelsy , Stokes Andrew C , Adams-Campbell Lucile , Marley Andrew R , Forman Michele R , Rosenberg Lynn , Bertrand Kimberly A
Published: January 2022

While excess weight is an established risk factor for postmenopausal breast cancer, consideration of maximum body mass index (maxBMI; BMI is calculated as weight (kg)/height (m)2) or BMI at a point in time relevant for breast carcinogenesis may offer new insights. We prospectively evaluated maxBMI and time-dependent BMI in relation to breast cancer incidence among 31,028 postmenopausal women in the Black Women’s Health Study. During 1995–2015, a total of 1,384 diagnoses occurred, including 787 estrogen-receptor (ER)–positive (ER+) cases and 310 ER-negative (ER−) cases. BMI was assessed at baseline and 2, 4, 6, and 8 years before diagnosis. Cox proportional hazards regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Compared with women with BMI <25, those with BMI ≥35 had increased risk of ER+ breast cancer but not ER− breast cancer. For BMI assessed 2 years before diagnosis, the HRs for ER+ breast cancer associated with maxBMI ≥35 and time-dependent BMI ≥35 were 1.42 (95% confidence interval (CI): 1.10, 1.84) and 1.63 (95% CI: 1.25, 2.13), respectively. The corresponding HR for time-dependent BMI assessed 6 years before diagnosis was 1.95 (95% CI: 1.45, 2.62). These findings suggest strong associations of BMI with risk of ER+ breast cancer in postmenopausal women, regardless of timing of BMI assessment.
Social Threat Reduces Alcohol Consumption among College Students
Authors: Hua Jacqueline , Johnson Angela E , Pino Sofia , Olson David , Nguyen Tony , Lawson Lacye , Bedolla Brendan , Howell Jennifer L
Published: January 2022

Aims

Past research suggests that people report a greater desire to consume alcohol when they experience social threat—or threats to their social selves, such as social exclusion. Nevertheless, experimental research on the role of social threat in alcohol consumption is limited. The present study examined the causal relationship between social threat and wine consumption.

Methods

Undergraduate students (N = 83; Mage = 21.8 years old, SDage = 1.62 years old; 72.3% women; 61.4% Latinx/Hispanic) participated in a study under the pretense that they were in a focus group gauging students’ opinions of a bar being constructed at their university. During the study, participants and two confederate researchers completed a group activity in which they selected design elements for the bar. Participants were randomly assigned to one of two conditions. In the social threat condition, confederates rejected participants’ design choices and socially excluded them during a follow-up task. In the social acceptance condition, confederates supported participants’ choices and did not socially exclude them. All participants then completed a wine taste test.

Results

Contrary to predictions, an independent-samples t-test revealed that participants who experienced social threat consumed significantly less wine than those who were socially accepted, t(81) = −2.22, P = 0.03, d = −0.49. Furthermore, a linear regression test revealed that this effect persisted even when controlling for typical alcohol-consumption behavior, b = 56.09, t = −2.50, P = 0.02, d = −0.61.

Conclusion

The relationship between social threat and alcohol consumption may be more nuanced than anticipated. Discussion centers around two potential moderators including positive affect and identity.
Fitch’s paradox and truthmaking: Why Jago’s argument remains ineffective
Authors: Nyseth Fredrik
Published: January 2022

Recently, there have been several attempts to use the kind of reasoning found in Fitch’s knowability paradox to argue for rather sweeping metaphysical claims: Jago (2020) uses such reasoning to argue that every truth has a truthmaker, and Loss (2021) does so to argue that every fact is grounded. This strategy has been criticized by Trueman (2021), who points out that the same kind of reasoning could be used to establish entirely opposite conclusions. In response, Jago (2021) has offered a revised argument that is meant to avoid Trueman’s objection. I argue that this revised argument is in fact undermined by an objection quite similar to Trueman’s.
Regeneration from seed in herbaceous understorey of ancient woodlands of temperate Europe
Authors: Blandino Cristina , Fernández-Pascual Eduardo , Newton Rosemary J , Pritchard Hugh W
Published: January 2022

Background and Aims

European ancient woodlands are subject to land use change, and the distribution of herbaceous understorey species may be threatened because of their poor ability to colonize isolated forest patches. The regeneration niche can determine the species assembly of a community, and seed germination traits may be important descriptors of this niche.

Methods

We analysed ecological records for 208 herbaceous species regarded as indicators of ancient woodlands in Europe and, where possible, collated data on seed germination traits, reviewed plant regeneration strategies and measured seed internal morphology traits. The relationship between plant regeneration strategies and ecological requirements was explored for 57 species using ordination and classification analysis.

Key Results

Three regeneration strategies were identified. Species growing in closed-canopy areas tend to have morphological seed dormancy, often requiring darkness and low temperatures for germination, and their shoots emerge in early spring, thus avoiding the competition for light from canopy species. These species are separated into two groups: autumn and late winter germinators. The third strategy is defined by open-forest plants with a preference for gaps, forest edges and riparian forests. They tend to have physiological seed dormancy and germinate in light and at higher temperatures, so their seedlings emerge in spring or summer.

Conclusion

Seed germination traits are fundamental to which species are good or poor colonizers of the temperate forest understorey and could provide a finer explanation than adult plant traits of species distribution patterns. Seed dormancy type, temperature stratification and light requirements for seed germination are important drivers of forest floor colonization patterns and should be taken in account when planning successful ecological recovery of temperate woodland understories.
Multi-channel graph attention autoencoders for disease-related lncRNAs prediction
Authors: Sheng Nan , Huang Lan , Wang Yan , Zhao Jing , Xuan Ping , Gao Ling , Cao Yangkun
Published: January 2022

Motivation

Predicting disease-related long non-coding RNAs (lncRNAs) can be used as the biomarkers for disease diagnosis and treatment. The development of effective computational prediction approaches to predict lncRNA-disease associations (LDAs) can provide insights into the pathogenesis of complex human diseases and reduce experimental costs. However, few of the existing methods use microRNA (miRNA) information and consider the complex relationship between inter-graph and intra-graph in complex-graph for assisting prediction.

Results

In this paper, the relationships between the same types of nodes and different types of nodes in complex-graph are introduced. We propose a multi-channel graph attention autoencoder model to predict LDAs, called MGATE. First, an lncRNA-miRNA-disease complex-graph is established based on the similarity and correlation among lncRNA, miRNA and diseases to integrate the complex association among them. Secondly, in order to fully extract the comprehensive information of the nodes, we use graph autoencoder networks to learn multiple representations from complex-graph, inter-graph and intra-graph. Thirdly, a graph-level attention mechanism integration module is adopted to adaptively merge the three representations, and a combined training strategy is performed to optimize the whole model to ensure the complementary and consistency among the multi-graph embedding representations. Finally, multiple classifiers are explored, and Random Forest is used to predict the association score between lncRNA and disease. Experimental results on the public dataset show that the area under receiver operating characteristic curve and area under precision-recall curve of MGATE are 0.964 and 0.413, respectively. MGATE performance significantly outperformed seven state-of-the-art methods. Furthermore, the case studies of three cancers further demonstrate the ability of MGATE to identify potential disease-correlated candidate lncRNAs. The source code and supplementary data are available at https://github.com/sheng-n/MGATE.

Contact

huanglan@jlu.edu.cn, wy6868@jlu.edu.cn
Adult Safeguarding Legislation—The Key to Addressing Dualism of Agency and Structure? An Exploration of how Irish Social Workers Protect Adults at Risk in the Absence of Adult Safeguarding Legislation
Authors: Donnelly Sarah , O'Brien Marita
Published: January 2022

Adult safeguarding is characterised by competing debates related to core concepts including policy and legislative frameworks. In some countries, to reconcile the dualism of agency and structure, conflict and ambiguity are legislated for through the introduction of adult safeguarding legislation (ASL). This study set out to explore how the absence of ASL in the Irish context impacts safeguarding processes. A qualitative approach involving semi-structured interviews (N = 14) and focus groups (N = 2) with social workers, explored variables from adult safeguarding cases that contribute to positive outcomes in the absence of ASL, and where legislation could have helped, using a critical incident technique. Four themes emerged: practices and processes; coercive control and undue influence; information sharing and multiagency cooperation; and inability to access services. Whilst in the majority of cases existing policy and legislation achieved successful outcomes, legislative powers such as a duty to cooperate, to share information and powers of entry were deemed necessary. This study suggests limits to safeguards and protections within current policy. It illustrates the dualism that often exists between the agency of social workers to act to safeguard adults at risk and the structural rules, relationships and resources that can restrict the context of action in absence of legislation.
Elevated lncRNA-UCA1 upregulates EZH2 to promote inflammatory response in sepsis-induced pneumonia via inhibiting HOXA1
Authors: Zhang Xiaoqin , Tang Xuemei , Pan Lingai , Li Yongheng , Li Junlei , Li Chunling
Published: January 2022

Sepsis is characterized by a dysregulated inflammatory response. We aimed to explore the role of the long noncoding RNA urothelial carcinoma associated 1 (lncRNA UCA1)/enhancer of zeste homolog 2 (EZH2)/homeobox A1 (HOXA1) axis in sepsis-induced pneumonia. The sepsis rat models and RLE-6TN cellular sepsis-induced pneumonia models were established using ligation and puncture (CLP) and lipopolysaccharide (LPS). The expression of UCA1, EZH2, and HOXA1 in rat lung tissues and RLE-6TN cells was detected. Then, the CLP rats were respectively treated with lentivirus to upregulate or downregulate the expression of UCA1 and EZH2 to measure their roles in the pathology, apoptosis, inflammation and phosphorylated NF-κB p65(p-p65) levels in CLP rat lung tissues. UCA1 and EZH2 expression was upregulated or downregulated in LPS-induced RLE-6TN cells to explore their effects on cell viability, apoptosis, inflammation and p-p65 levels. The interactions among UCA1, EZH2, and HOXA1 were identified. UCA1 and EZH2 were upregulated whereas HOXA1 was downregulated in CLP rat lung tissues and LPS-induced RLE-6TN cells. Elevated UCA1 or increased EZH2 aggravated pathology and promoted apoptosis, inflammation and phosphorylated NF-κB p-65 levels in CLP rat lung tissues, and inhibited viability while facilitated apoptosis, inflammation and phosphorylated NF-κB p-65 levels in LPS-induced RLE-6TN cells. Silenced EZH2 reversed the effects of UCA1 elevation on sepsis-induced pneumonia. UCA1 suppressed HOXA1 expression through physically interacting with EZH2. UCA1 overexpression upregulates EZH2 to repress HOXA1 expression, thus aggravating the progression of sepsis-induced pneumonia, which could be alleviated by EZH2 inhibition.
Electrophysiological heterogeneity in large populations of rabbit ventricular cardiomyocytes
Authors: Lachaud Quentin , Aziz Muhamad Hifzhudin Noor , Burton Francis L , Macquaide Niall , Myles Rachel C , Simitev Radostin D , Smith Godfrey L
Published: January 2022

Aims

Cardiac electrophysiological heterogeneity includes: (i) regional differences in action potential (AP) waveform, (ii) AP waveform differences in cells isolated from a single region, (iii) variability of the contribution of individual ion currents in cells with similar AP durations (APDs). The aim of this study is to assess intra-regional AP waveform differences, to quantify the contribution of specific ion channels to the APD via drug responses and to generate a population of mathematical models to investigate the mechanisms underlying heterogeneity in rabbit ventricular cells.

Methods and results

APD in ∼50 isolated cells from subregions of the LV free wall of rabbit hearts were measured using a voltage-sensitive dye. When stimulated at 2 Hz, average APD90 value in cells from the basal epicardial region was 254 ± 25 ms (mean ± standard deviation) in 17 hearts with a mean interquartile range (IQR) of 53 ± 17 ms. Endo-epicardial and apical-basal APD90 differences accounted for ∼10% of the IQR value. Highly variable changes in APD occurred after IK(r) or ICa(L) block that included a sub-population of cells (HR) with an exaggerated (hyper) response to IK(r) inhibition. A set of 4471 AP models matching the experimental APD90 distribution was generated from a larger population of models created by random variation of the maximum conductances (Gmax) of 8 key ion channels/exchangers/pumps. This set reproduced the pattern of cell-specific responses to ICa(L) and IK(r) block, including the HR sub-population. The models exhibited a wide range of Gmax values with constrained relationships linking ICa(L) with IK(r), ICl, INCX, and INaK.

Conclusion

Modelling the measured range of inter-cell APDs required a larger range of key Gmax values indicating that ventricular tissue has considerable inter-cell variation in channel/pump/exchanger activity. AP morphology is retained by relationships linking specific ionic conductances. These interrelationships are necessary for stable repolarization despite large inter-cell variation of individual conductances and this explains the variable sensitivity to ion channel block.
Age-related enhanced degeneration of bioprosthetic valves due to leaflet calcification, tissue crosslinking, and structural changes
Authors: Xue Yingfei , Kossar Alexander P , Abramov Alexey , Frasca Antonio , Sun Mingze , Zyablitskaya Mariya , Paik David , Kalfa David , Della Barbera Mila , Thiene Gaetano , Kozaki Satoshi , Kawashima Takayuki , Gorman Joseph H , Gorman Robert C , Gillespie Matthew J , Carreon Chrystalle Katte , Sanders Stephen P , Levy Robert J , Ferrari Giovanni
Published: January 2022

Aims

Bioprosthetic heart valves (BHVs), made from glutaraldehyde-fixed heterograft materials, are subject to more rapid structural valve degeneration (SVD) in paediatric and young adult patients. Differences in blood biochemistries and propensity for disease accelerate SVD in these patients, which results in multiple re-operations with compounding risks. The goal of this study is to investigate the mechanisms of BHV biomaterial degeneration and present models for studying SVD in young patients and juvenile animal models.

Methods and results

We studied SVD in clinical BHV explants from paediatric and young adult patients, juvenile sheep implantation model, rat subcutaneous implants, and an ex vivo serum incubation model. BHV biomaterials were analysed for calcification, collagen microstructure (alignment and crimp), and crosslinking density. Serum markers of calcification and tissue crosslinking were compared between young and adult subjects. We demonstrated that immature subjects were more susceptible to calcification, microstructural changes, and advanced glycation end products formation. In vivo and ex vivo studies comparing immature and mature subjects mirrored SVD in clinical observations. The interaction between host serum and BHV biomaterials leads to significant structural and biochemical changes which impact their functions.

Conclusions

There is an increased risk for accelerated SVD in younger subjects, both experimental animals and patients. Increased calcification, altered collagen microstructure with loss of alignment and increased crimp periods, and increased crosslinking are three main characteristics in BHV explants from young subjects leading to SVD. Together, our studies establish a basis for assessing the increased susceptibility of BHV biomaterials to accelerated SVD in young patients.
Rapid-deployment aortic valve replacement for patients with bicuspid aortic valve: a single-centre experience
Authors: Coti Iuliana , Werner Paul , Kaider Alexandra , Mach Markus , Kocher Alfred , Laufer Guenther , Andreas Martin
Published: January 2022

OBJECTIVES

The benefit of rapid-deployment aortic valve replacement (RD-AVR) in patients with a bicuspid aortic valve (BAV) is controversial due to aortic root asymmetry and potential increased risk for valve dislocation and paravalvular leak. This study aimed to analyse the outcomes of surgical aortic valve replacement with a rapid-deployment bioprosthesis in patients with a BAV.

METHODS

Between May 2010 and December 2020, all consecutive patients who underwent RD-AVR at the Medical University of Vienna were included in our institutional database. Assessment of preoperative characteristics, operative outcomes, long-term survival and clinical events was performed. The outcomes of patients presenting with a native BAV were compared with a control group of patients with native tricuspid valve (TAV); reoperative aortic valve replacements were excluded.

RESULTS

Out of 816 patients, who underwent RD-AVR at our institution, 107 patients with a BAV, mean age 68 (standard deviation: 8) years, were compared with a control group of 690 patients with a TAV, mean age 74 (standard deviation: 7) years; patients presenting with a BAV were significantly younger than patients with a TAV (P < 0.001). Concomitant procedures were performed in 44 (41.1%) patients in the BAV group and in 339 (49.1%) patients in the TAV group (P = 0.123); surgery of the ascending aorta was necessary in 24 (22.4%) in the BAV group, compared with 29 (4.2%) in the control group (P < 0.001). The 5-year cumulative incidence of moderate-to-severe paravalvular regurgitation in the BAV group was 10.7% [95% confidence interval (CI): 4.2–20.7%] and 3.9% (95% CI: 2.4–6.1%) in the TAV group (P = 0.057). Reoperation with valve explantation due to non-structural valve dysfunction at 5 years was 2.8% (95% CI: 0.5–8.8%) in the BAV group, compared to 1.9% (95% CI: 1.0–3.2%) in the TAV cohort (P = 0.89). The overall long-term survival rate in the BAV group was 92% (95% CI: 81–97%) at 5 years and 88% (95% CI: 73–95%), at 10 years, significantly better compared to the TAV group (log-rank test P = 0.002).

CONCLUSIONS

RD-AVR can be performed in patients with a BAV with convincingly medical outcomes. However, a trend to increased frequency of moderate–severe paravalvular regurgitation was observed at long-term follow-up. Consequently, a different surgical approach, compared to tricuspid valves, with distinctly specific technical- and anatomical considerations and requirements, is recommended.
Validation of seismic velocity models in southern California with full-waveform simulations
Authors: Lu Y , Ben-Zion Y
Published: January 2022

Crustal seismic velocity models provide essential information for many applications including earthquake source properties, simulations of ground motion and related derivative products. We present a systematic workflow for assessing the accuracy of velocity models with full-waveform simulations. The framework is applied to four regional seismic velocity models for southern California: CVM-H15.11, CVM-S4.26, CVM-S4.26.M01 that includes a shallow geotechnical layer, and the model of Berg et al. For each model, we perform 3-D viscoelastic wave propagation simulations for 48 virtual seismic noise sources (down to 2 s) and 44 moderate-magnitude earthquakes (down to 2 s generally and 0.5 s for some cases) assuming a minimum shear wave velocity of 200 m s–1. The synthetic waveforms are compared with observations associated with both earthquake records and noise cross-correlation data sets. We measure, at multiple period bands for well-isolated seismic phases, traveltime delays and normalized zero-lag cross-correlation coefficients between the synthetic and observed data. The obtained measurements are summarized using the mean absolute derivation of time delay and the mean correlation coefficient. These two metrics provide reliable statistical representations of model quality with consistent results in all data sets. In addition to assessing the overall (average) performance of different models in the entire study area, we examine spatial variations of the models’ quality. All examined models show good phase and waveform agreements for surface waves at periods longer than 5 s, and discrepancies at shorter periods reflecting small-scale heterogeneities and near-surface structures. The model performing best overall is CVM-S4.26.M01. The largest misfits for both body and surface waves are in basin structures and around large fault zones. Inaccuracies generated in these areas may affect tomography and model simulation results at other regions. The seismic velocity models for southern California can be improved by adding better resolved structural representations of the shallow crust and volumes around the main faults.
False lumen being larger than true lumen is associated with late aortic events in uncomplicated type B aortic dissection
Authors: Matsushita Akihito , Tabata Minoru , Hattori Takashi , Mihara Wahei , Sato Yasunori
Published: January 2022

OBJECTIVES

In uncomplicated type B aortic dissection, a large false lumen (FL) is reportedly a risk factor for late aortic events. However, it is unclear how the relationship between the false and true lumen (TL) diameters affects the dissected aorta. This study aimed to evaluate the impact on clinical outcomes of the FL being larger than the TL.

METHODS

We retrospectively reviewed 111 consecutive patients with uncomplicated acute type B aortic dissection between 2004 and 2018. We divided the patients into group A (FL > TL; n = 51) and group B (FL ≤ TL; n = 60), and compared the outcomes. The endpoints were aortic events, including surgery for aortic dissection and indication for surgery, and mortality.

RESULTS

The 5-year incidence rates of aortic events were 68.4% in Group A and 33.6% in Group B (P = 0.002). The 5-year all-cause mortality rates were 5.3% in Group A and 21.9% in Group B (P = 0.003). The multivariable analyses revealed that FL > TL was an independent factor associated with aortic events (adjusted hazard ratio 2.482, 95% confidence interval 1.467–4.198, P < 0.001), but had low mortality (adjusted hazard ratio 0.209, 95% confidence interval 0.073–0.597, P = 0.003).

CONCLUSIONS

Patients with uncomplicated type B aortic dissection with FL > TL at admission are at increased risk of aortic events but improve mortality compared to patients with FL ≤ TL.

Clinical trial registration

UMIN000036997.
Mild Ill-Posedness inL∞ for 2D Resistive MHD Equations Near a Background Magnetic Field
Authors: Wu Jiahong , Zhao Jiefeng
Published: January 2022

The global well-posedness on the 2D resistive MHD equations without kinematic dissipation remains an outstanding open problem. This is a critical problem. Any $L^p$-norm of the vorticity $\omega $ with $1\le p<\infty $ has been shown to be bounded globally (in time), but whether the $L^\infty $-norm of $\omega $ is globally bounded remains elusive. The global boundedness of $\|\omega \|_{L^\infty }$ yields the resolution of the aforementioned open problem. This paper examines the $L^\infty $-norm of $\omega $ from a different perspective. We construct a sequence of initial data near a special steady state to show that the $L^\infty $-norm of $\omega $ is actually mildly ill-posed.
Exploring the Human and Animal Relationship in the Hebrew Bible Through the Blood Prohibition
Authors: Sabo Peter
Published: January 2022

This paper argues that the primary purpose of the blood prohibition in the Hebrew Bible is not to reflect ethical sensitivity toward animals; rather, it is part of an anthropocentric ideology that promotes both human ascendancy over, and kinship with, animals. The blood prohibition places a high value on animal life, but it does this to justify, and socially authorize, the eating of animals while simultaneously alleviating the deeply embedded human guilt over killing them. To display this, I contrast how animals and blood function in the Priestly texts of the Hebrew Bible versus the non-Priestly texts—focusing on the primeval history of Genesis and the book of Leviticus. Most tellingly, the non-Priestly material in the primeval history contains no blood prohibition and thus does not contain the profound ambivalence toward animals and eating them that the Priestly material does.
Field Assessment of Oryzophagus oryzae (Coleoptera: Curculionidae) Preference and Performance on Selected Rice Cultivars
Authors: de Bastos Pazini Juliano , Dionei Grützmacher Anderson , Júnior Seidel Enio , Costa Padilha Aline , Felisberto da Silva Fernando , Bernardi Daniel , Orrin Way Michael , da Silva Martins José Francisco
Published: January 2022

Plant resistance is a key strategy for the management of Oryzophagus oryzae (Costa Lima) (Coleoptera: Curculionidae), an important pest in South American rice paddies. The present study investigated the resistance of rice cultivars in terms of feeding and oviposition preference, growth, development, and biological performance of O. oryzae under natural conditions of field infestation during two consecutive rice seasons. There were no effects of the six cultivars on the feeding and oviposition preferences of O. oryzae as evaluated 5, 8, and 11 d After Flooding (DAF) of the plots, indicating the absence of antixenosis. Cultivars did not differ in terms of egg viability and larval density of first instars on the roots at 15 DAF. Significant differences were found 25 and 35 DAF when larval density per sample was high on ‘BRS Pampa CL’ (up to 24.5), intermediate on ‘BRS Querência’ and ‘BRS Ligeirinho’ (up to 16.1), and low on ‘BRS Atalanta’, ‘BRS Firmeza’, and ‘Dawn’ (up to 8.8). The cultivars ‘BRS Atalanta’, ‘BRS Firmeza’, and ‘Dawn’ caused malnutrition and inhibition of larval growth. These effects, typical of antibiosis, resulted in delayed pupation and emergence of adults; in addition, emerged females had body weight decreased strongly. The cultivars BRS Pampa CL, BRS Querência, and BRS Ligeirinho are susceptible, resulting in high larval populations and more suitable development of O. oryzae; antibiosis, as indicated for ‘BRS Atalanta’, ‘BRS Firmeza’, and ‘Dawn’, probably is the key mechanism of rice resistance to O. oryzae.
Detection of Trypansoma cruzi in Kissing Bugs (Hemiptera: Reduviidae: Triatominae) Collected Across Oklahoma
Authors: Allen Kelly E , Lineberry Megan W
Published: January 2022

Trypanosoma cruzi is the causative agent of Chagas disease in humans and dogs in the Americas. Transmission predominantly occurs via the feces of infected kissing bugs (Hemiptera: family Reduviidae; subfamily Triatominae) contaminating bite site wounds or mucous membranes. To better understand Chagas disease entomologic risk in Oklahoma, kissing bugs collected from within the state were tested for T. cruzi DNA. Data including county of insect collection, species and instar, and specific locations where specimens were found were collated. Triatomines were also tested by PCR to potentially identify DNA of vertebrate species on which specimens had recently fed. In total, 110 kissing bugs from 22 counties were tested. All triatomines were identified as Triatoma sanguisuga nymphs or adults, with the exception of one possible T. lecticularia adult. Trypanosoma cruzi DNA was detected in 22 (20%) triatomines from 12 counties spanning the state. The majority of T. cruzi PCR positive kissing bugs were found inside homes or associated structures (i.e., garages, porches). Vertebrate DNA was identified in 27 (24.5%) triatomines, with human DNA detected in 25 (92.6%) of these specimens, and canine and raccoon DNA detected in one specimen each (3.7%). Two specimens tested positive for both T. cruzi and human DNA and one specimen tested positive for both T. cruzi and raccoon DNA. Results from this study indicate that kissing bugs carrying T. cruzi are widespread in Oklahoma, that positive kissing bugs infest homes and associated structures, and that human-vector, canine-vector, and wildlife-vector contact all occur within the state.
Biology and Clinical Implications of Fecal Occult Blood Test Screen-Detected Colorectal Cancer
Authors: Mendis Shehara , Hong Wei , Ananda Sumitra , Faragher Ian , Jones Ian , Croxford Matthew , Steel Malcolm , Jalali Azim , Gard Grace , To Yat Hang , Lee Margaret , Kosmider Suzanne , Wong Rachel , Tie Jeanne , Gibbs Peter
Published: January 2022

Background

Fecal occult blood test (FOBT)–based screening for colorectal cancer (CRC) reduces mortality, with earlier stage at diagnosis a prominent feature. Other characteristics of FOBT screen-detected cancers and any implications for clinical management have not been well explored.

Methods

We examined a multisite clinical registry to compare the characteristics and outcomes of FOBT screen-detected CRC via the Australian National Bowel Cancer Screening Program (NBCSP), which is offered biennially to individuals aged 50-74 years, and age-matched non-screen-detected CRC in the same registry. All statistical tests were 2-sided. Odds ratios (ORs) were calculated using the Baptista-Pike method, and hazard ratios via the log-rank method.

Results

Of 7153 registry patients diagnosed June 1, 2006, to June 30, 2020, 4142 (57.9%) were aged between 50 and 74 years. Excluding 406 patients with non-NBCSP screen-detected cancers and 35 patients with unknown method of detection, 473 (12.8%) were screen detected via the NBCSP, and 3228 (87.2%) were non-screen detected. Screen-detected patients were younger (mean age = 62.4 vs 64.2 years; P < .001) and more medically fit (OR for ASA score 1-2 = 1.91, 95% confidence interval [CI] = 1.51 to 2.41; P < .001). Pathologic characteristics within each stage favored the screen-detected patients. Stage III screen-detected colon cancers were more likely to receive adjuvant therapy (OR = 3.58, 95% CI = 1.52 to 8.36; P = .002). Screen-detected patients had superior relapse-free (hazard ratio = 0.41, 95% CI = 0.29 to 0.60; P < .001) and overall survival (hazard ratio = 0.22, 95% CI = 0.15 to 0.35; P < .001), which was maintained in matched stage comparisons and multivariable analysis.

Conclusions

Beyond stage at diagnosis, multiple other factors associated with a favorable outcome are observed in FOBT screen-detected CRC. Given the substantial stage-by-stage differences in survival outcomes, if independently confirmed, individualized adjuvant therapy and surveillance strategies could be warranted for FOBT screen-detected cancers.
Cultivating Collaborative Resilience to Social and Ecological Change: An Assessment of Adaptive Capacity, Actions, and Barriers Among Collaborative Forest Restoration Groups in the United States
Authors: Beeton Tyler A , Cheng Antony S , Colavito Melanie M
Published: January 2022

Collaboration is increasingly emphasized as a tool to realize national-level policy goals in public lands management. Yet, collaborative governance regimes (CGRs) are nested within traditional bureaucracies and are affected by internal and external disruptions. The extent to which CGRs adapt and remain resilient to these disruptions remains under-explored. Here, we distill insights from an assessment of the Collaborative Forest Landscape Restoration Program (CFLRP) projects and other CGRs. We asked (1) how do CGRs adapt to disruptions? and (2) what barriers constrained CGR resilience? Our analysis is informed by a synthesis of the literature, case examples and exemplars from focus groups, and a national CFLRP survey. CGRs demonstrated the ability to mobilize social capital, learning, resources, and flexibility to respond to disruptions. Yet authority, accountability, and capacity complicated collaborative resilience. We conclude with policy and practice recommendations to cultivate collaborative resilience moving forward.
Cosmic rays from massive star clusters: a close look at Westerlund 1
Authors: Bhadra Sourav , Gupta Siddhartha , Nath Biman B , Sharma Prateek
Published: January 2022

We study the effect of cosmic ray (CR) acceleration in the massive compact star cluster Westerlund 1 in light of its recent detection in γ-rays. Recent observations reveal a 1/r radial distribution of the CR energy density. Here, we theoretically investigate whether or not this profile can help to distinguish between (1) continuous CR acceleration in the star cluster stellar wind-driven shocks and (2) discrete CR acceleration in multiple supernovae (SNe) shocks – which are often debated in the literature. Using idealized two-fluid simulations and exploring different acceleration sites and diffusion coefficients, we obtain the CR energy density profile and luminosity to find the best match for the γ-ray observations. We find that the inferred CR energy density profiles from observations of γ-ray luminosity and mass can be much different from the true radial profile. CR acceleration at either the cluster core region or the wind termination shock can explain the observations, if the diffusion coefficient is κcr ∼ 1027 cm2 s−1 and a fraction of ${\approx}10-20{{\ \rm per\ cent}}$ of the shock power/post-shock pressure is deposited into the CR component. We also study the possibility of discrete SNe explosions being responsible for CR acceleration and find that with an injection rate of 1 SN in every ∼0.03 Myr, one can explain the observed γ-ray profile. This multiple SN scenario is consistent with X-ray observations only if the thermal conductivity is close to the Spitzer value.
Benchmarking of a Bayesian single cell RNAseq differential gene expression test for dose–response study designs
Authors: Nault Rance , Saha Satabdi , Bhattacharya Sudin , Dodson Jack , Sinha Samiran , Maiti Tapabrata , Zacharewski Tim
Published: January 2022

The application of single-cell RNA sequencing (scRNAseq) for the evaluation of chemicals, drugs, and food contaminants presents the opportunity to consider cellular heterogeneity in pharmacological and toxicological responses. Current differential gene expression analysis (DGEA) methods focus primarily on two group comparisons, not multi-group dose–response study designs used in safety assessments. To benchmark DGEA methods for dose–response scRNAseq experiments, we proposed a multiplicity corrected Bayesian testing approach and compare it against 8 other methods including two frequentist fit-for-purpose tests using simulated and experimental data. Our Bayesian test method outperformed all other tests for a broad range of accuracy metrics including control of false positive error rates. Most notable, the fit-for-purpose and standard multiple group DGEA methods were superior to the two group scRNAseq methods for dose–response study designs. Collectively, our benchmarking of DGEA methods demonstrates the importance in considering study design when determining the most appropriate test methods.
Polympact: exploring functional relations among common human genetic variants
Authors: Valentini Samuel , Gandolfi Francesco , Carolo Mattia , Dalfovo Davide , Pozza Lara , Romanel Alessandro
Published: January 2022

In the last years, many studies were able to identify associations between common genetic variants and complex diseases. However, the mechanistic biological links explaining these associations are still mostly unknown. Common variants are usually associated with a relatively small effect size, suggesting that interactions among multiple variants might be a major genetic component of complex diseases. Hence, elucidating the presence of functional relations among variants may be fundamental to identify putative variants’ interactions. To this aim, we developed Polympact, a web-based resource that allows to explore functional relations among human common variants by exploiting variants’ functional element landscape, their impact on transcription factor binding motifs, and their effect on transcript levels of protein-coding genes. Polympact characterizes over 18 million common variants and allows to explore putative relations by combining clustering analysis and innovative similarity and interaction network models. The properties of the network models were studied and the utility of Polympact was demonstrated by analysing the rich sets of Breast Cancer and Alzheimer's GWAS variants. We identified relations among multiple variants, suggesting putative interactions. Polympact is freely available at bcglab.cibio.unitn.it/polympact.
Protoplast fusion in Bacillus species produces frequent, unbiased, genome-wide homologous recombination
Authors: Vasileva Delyana P , Streich Jared C , Burdick Leah H , Klingeman Dawn M , Chhetri Hari B , Brelsford Christa M , Ellis J Christopher , Close Dan M , Jacobson Daniel A , Michener Joshua K
Published: January 2022

In eukaryotes, fine-scale maps of meiotic recombination events have greatly advanced our understanding of the factors that affect genomic variation patterns and evolution of traits. However, in bacteria that lack natural systems for sexual reproduction, unbiased characterization of recombination landscapes has remained challenging due to variable rates of genetic exchange and influence of natural selection. Here, to overcome these limitations and to gain a genome-wide view on recombination, we crossed Bacillus strains with different genetic distances using protoplast fusion. The offspring displayed complex inheritance patterns with one of the parents consistently contributing the major part of the chromosome backbone and multiple unselected fragments originating from the second parent. Our results demonstrate that this bias was in part due to the action of restriction–modification systems, whereas genome features like GC content and local nucleotide identity did not affect distribution of recombination events around the chromosome. Furthermore, we found that recombination occurred uniformly across the genome without concentration into hotspots. Notably, our results show that species-level genetic distance did not affect genome-wide recombination. This study provides a new insight into the dynamics of recombination in bacteria and a platform for studying recombination patterns in diverse bacterial species.
Rapidly progressive IgA nephropathy: clinicopathological characteristics and outcomes assessed according to the revised definition of the KDIGO 2021 Guideline
Authors: Yu Bingxin , Shi Sufang , Lv Jicheng , Liu Lijun , Zhou Xujie , Zhu Li , Chen Pei , Yang Hongyu , Wang Zi , Wang Suxia , Barratt Jonathan , Zhang Hong
Published: January 2022

Background

Rapidly progressive immunoglobulin A nephropathy (RPIgAN) is a severe clinical phenotype of IgAN associated with a poor outcome. The recently published Kidney Disease: Improving Global Outcomes (KDIGO) 2021 Guideline for the Management of Glomerular Diseases has proposed a new definition for RPIgAN that is based simply on a ≥50% decline in the estimated glomerular filtration rate (eGFR) over ≤3 months.

Methods

In 1677 IgAN patients followed at a single centre in China, we evaluated the utility of this new definition to identify the highest-risk IgAN patients who might be suitable for combination immunosuppressive therapy.

Results

The proportion of a ≥50% decline in eGFR over ≤3 months was 5.2%. The majority of these patients had reversible causes, with only 2.3% (39/1677) meeting the KDIGO 2021 criteria for RPIgAN. These patients had a significantly higher risk for end-stage kidney disease (ESKD) than non-RPIgAN patients (logrank P < 0.001). RPIgAN was an independent risk factor for ESKD [hazard ratio 3.99 (95% confidence interval 2.25–7.09); P <0.001]. A minority of the RPIgAN patients (25.6%) had ≥50% crescents. There was no significant difference in the risk for ESKD between patients in the RPIgAN group with ≥50% crescents and ˂50% crescents (logrank P = 0.27). Patients with RPIgAN and ≥50% crescents had a higher risk for ESKD than patients with non-RPIgAN and ≥50% crescents (logrank P = 0.04).

Conclusions

These data support the validity of the KDIGO 2021 definition but require independent validation in other non-Chinese cohorts.