bluuebunny/crossref_metadata_2025 huggingface dataset:
A BIM-Based Quality Inspection System Prototype for Temporary Construction Works
Authors: Choi Chang Hoon , Lee Junbok
Published: November 2022

In the construction project, the temporary work is the construction work, which is installed temporarily for the construction of main structure and removed after its completion. Even though it is a temporary facility used and demolished only during the construction phase, it accounts for about 10% of the total construction cost. In addition, it is an important work directly connected to the cost and quality of construction, so that the completeness of the building depends on the technology of the temporary work. Therefore, it is necessary to manage it through systematic quality inspection activities. In order to perform a systematic quality inspection, it is essential that detailed and specific inspection activities, such as inspecting the conformity of the design and construction and its compliance with relevant standards based on construction inspection information, such as drawings, specifications, and checklists, are carried out. However, most of the construction inspection information about the temporary work does not include any specific information in documents (drawings, specifications, etc.). Additionally, the direct temporary work among the temporary works is treated as an auxiliary work of the main structure work in the construction site, although it is the construction work based on the work breakdown structure. Accordingly, the quality control engineer must manually check only the contents of the temporary work among the construction inspection information that covers the overall construction work. Additionally, the probability of human error is increased, as the quality control engineer manually carries out the quality inspection tasks, such as preparing the inspection-related materials and checklist and writing the inspection result report. This leads to inefficiency and problems such as re-provisioning for inspection and re-inspection. Therefore, it is necessary to construct a business process that can efficiently carry out the quality inspection work by complementing and improving the above problems involving the temporary work, which is performed most inefficiently. In this study, a BIM-based quality inspection system prototype for temporary works was developed that can automate tasks and systematically store and manage various types of inspection information for each of the temporary facilities in order to improve the efficiency of the quality inspection carried out by the quality control engineer. As a result, a process designed to improve the quality inspection of the temporary work, which can perform the quality inspection work, is proposed. Additionally, the quality of the works related to quality control is improved through improvements in the accuracy and efficiency of the works and simplification of the existing manual work procedures through the proposed business improvement process.
Design and Properties of Coal Gangue-Based Geopolymer Mortar
Authors: Zhao Yanbing , Yang Caiqian , Yan Chengyu , Yang Jing , Wu Zhiren
Published: November 2022

The feasibility of preparing coal gangue-based geopolymer mortar (CGBGM) with composite-activated coal gangue was experimentally explored in this paper. The effects of water-to-binder ratio (W/B), alkali content (A), and slag content (S) on the fluidity and performances of the CGBGM were experimentally investigated. The ANOVA method was employed to evaluate the significance level of influenced factors. Moreover, the microstructure, element compositions, and qualitative microanalysis of the CGBGM at various curing ages were verified by ESEM-EDS. Test results denoted that the mechanical properties of the CGBGM are superior to that of ordinary Portland cement mortar (OPCM). The flexural and compressive strength of the CGBGM rapidly increases before 7 d and then tends to slow afterward. According to the impact degree on the flexural and compressive strength of the CGBGM, the S is ranked first, followed by the A, and finally the W/B. The flexural and compressive strength of specimens with 40% slag increased by 45.97% and 90.75%, respectively, compared to the control group. However, the A and W/B have little effect on flexural strength. In addition, the hydration productions filled in the crevice and healed the entrapped microcracks in the hardened paste with the increase in curing ages, forming a dense microstructure. The Ca/Si decreased from 0.5 at 3 d to 0.06 at 28 d, and the Ca/Al decreased from 0.25 at 3 d to 0.05 at 28 d. Finally, the difference in drying shrinkage behavior between the CGBGM and OPCM was systematically analyzed.
Preparation of C3N4 Thin Films for Photo-/Electrocatalytic CO2 Reduction to Produce Liquid Hydrocarbons
Authors: Zheng Jin You , Pawar Amol Uttam , Kang Young Soo
Published: November 2022

Thermal vapor condensation of melamine at various temperatures was used to fabricate thin graphitic carbon nitride (g-C3N4) films on fluorine-doped tin oxide (FTO) coated glass substrates. Photoanodic (n-type) and photocathodic (p-type) responses were observed simultaneously in the g-C3N4 films. The g-C3N4 film formed at 520 °C with the longest average lifetime of the photo-excited electrons shows the best cathodic photocurrent performance, which was then chosen for electrochemical and photoelectrochemical reduction of CO2. When the basic electrolyte (CO2-saturated 0.5 M KHCO3, pH = 7.6) was adopted, CO2 was electrochemically converted into formaldehyde ((54.6 μM/h)) in the liquid product. When the acidic electrolyte (CO2-saturated 0.5 M KCl, pH = 4.1) was adopted, formaldehyde (39.5 μM/h) and ethanol (15.7 μM/h) were generated through photoelectrochemical reduction, stimulated by the presence of sufficient protons from the electrolyte in the reduction process. Therefore, the pure g-C3N4 film has a great potential for CO2 reduction to value-added liquid hydrocarbons products via electrochemical or photoelectrochemical ways.
Body Composition Characteristics of Type 1 Diabetes Children and Adolescents: A Hospital-Based Case-Control Study in Uganda
Authors: Nsamba Jonathan , Eroju Priscilla , Drenos Fotios , Mathews Elezebeth
Published: November 2022

Background: Changes in body composition have been suggested as an intractable effect of Type 1 Diabetes Mellitus and its management. This study aims to compare body composition characteristics in a sample of young children and adolescents with Type 1 Diabetes Mellitus with healthy controls. Methods: In this case–control study, body composition was assessed using bioelectrical impedance among 328 participants. Anthropometric measurements included weight, height, upper arm, hip, and waist, circumferences; biceps; triceps; and subscapular and suprailiac skinfolds. From raw Bioelectrical impedance data, we calculated the impedance, phase angle, and height normalised resistance and reactance to assess body composition. Analysis of variance accounting for paired blocks was used to compare the two matched groups, while an independent Student’s t-test was used for intragroup comparisons among cases. Results: Waist Hip Ratio, biceps, triceps, subscapular and suprailiac skinfolds were higher among cases than in controls. Cases showed a higher Fat Mass Index, higher fasting blood glucose and higher glycated haemoglobin. Cases also had a higher mean value of resistance (p = 0.0133), and a lower mean value of reactance (p = 0.0329). Phase angle was lower among cases than in controls (p < 0.001). Conclusion: Our diabetic children showed higher levels of adiposity than controls. The observed differences in body composition are explained by differences in the fat-mass index. Abdominal fat accumulation was associated with poor glycaemic control and a lower phase angle.
Childhood Diarrhea Prevalence and Uptake of Oral Rehydration Solution and Zinc Treatment in Nigeria
Authors: Egbewale Bolaji Emmanuel , Karlsson Omar , Sudfeld Christopher Robert
Published: November 2022

Given the disproportionate burden of childhood diarrhea deaths in Nigeria, this study assessed the prevalence and predictors of the disease and the uptake of ORS and zinc supplementation as treatments in a population-based national survey. Cross-sectional data from the 2018 Nigeria Demographic Health Survey were used. A log-Poisson regression was used to estimate the relative risks (RR) for the individual-level predictors of childhood diarrhea and the uptake of ORS and zinc treatments. A total of 30,713 children under 5 years of age were included in the survey. The period prevalence of reported diarrhea in the last two weeks was 12.9% (95% CI: 12.5%, 13.3%). Among the children with diarrhea, the proportion who received ORS was 39.7% (95% CI: 38.2%, 41.3%), while 29.1% of them received zinc supplements (95% CI: 27.7%, 30.5%), and 21.8% of them received both the ORS and zinc treatments as recommended. Children under 6 months of age with diarrhea had a significantly lower likelihood of being given ORS or zinc when they were compared to the older children. The institutional delivery of them, maternal employment, and improved water sources were also independent predictors of the uptake of ORS and zinc treatments for diarrhea (p-values < 0.05). Interventions to prevent childhood diarrhea and improve the coverage of ORS and zinc treatments may reduce the large burden of childhood diarrhea deaths in Nigeria.
Predicting the Geographical Distribution Shift of Medicinal Plants in South Africa Due to Climate Change
Authors: Tshabalala Thulani , Mutanga Onisimo , Abdel-Rahman Elfatih M.
Published: November 2022

There has been a recent rise in the number of medicinal plant users in Southern Africa, with approximately a million users reported to utilize these plants for various health conditions. Unfortunately, some of these plants are reportedly endangered and facing extinction due to harvesting pressure. In addition, climate change is likely to negatively affect the geographical distribution of these medicinal plants. In the current study, future greenhouse gas emission scenarios of the representative concentration pathways, RCP2.6 and RCP8.5, for future projections to 2050 and 2080 were used to simulate the effect of climate change on three medicinal plants’ (Aloe ferox, Bowiea volubilis, and Dioscorea elephantipes) distribution in South Africa. We studied these plant species as the International Union for Conservation of Nature stated that A. ferox is currently of least concern in South Africa, while B. volubilis and D. elephantipes are categorised as declining and vulnerable, respectively. Specifically, we utilised a species distribution model (i.e., the maximum entropy: MaxEnt) to investigate the effect of climate change on the future spatial distribution of medicinal plants in South Africa. In 2050 and 2080, under both RCP scenarios, the suitable habitat of the studied plant species will reduce in the country’s northern parts. Specifically, the habitat for D. elephantipes will totally disappear in the country’s northern parts. However, there will be slight additions of suitable habitats for the species in the country’s southern parts. Model validation indicated that the area under curve (AUC) for A. ferox was 0.924 ± 0.004, while for B. volubilis and D. elephantipes it was 0.884 ± 0.050 and 0.944 ± 0.030, respectively. Using the results from this study, there is a need for the long-term in situ and ex situ conservation of these medicinal plants. The results of the present study could guide the development of effective and efficient policies and strategies for managing and conserving medicinal plants in South Africa.
Current and Prospective Applications of 3D Printing in Cosmetics: A Literature Review
Authors: Jiao Yimeng , Stevic Milica , Buanz Asma , Uddin Md Jasim , Tamburic Slobodanka
Published: November 2022

3D printing (3DP) is a manufacturing technology that produces 3D objects from a design file using layer-by-layer deposition of material. It has already found applications in the healthcare and pharmaceutical industries, while its use in the field of topical delivery has been extensively studied in the last two decades. The aim of this study is to provide a comprehensive overview of the 3DP-based developments in topical delivery, with special emphasis on its current and potential use in the cosmetic field. This review covers the principles and main types of 3DP technology, production, and characteristics of two key 3DP skin delivery platforms (patches and microneedles—MNs), as well as topical active materials used, focusing on those for cosmetic application. A comprehensive search of peer-reviewed articles in relevant databases was performed (including PubMed, Wiley Online Library, Multidisciplinary Digital Publishing Institute, Kosmet, ScienceDirect and Scopus) from 2004 to date. The study concludes that 3D printed MNs would gain prevalence over patches for both pharmaceutical and cosmetic applications and that dissolving MNs have the highest potential among them. The use of 3DP technology appears to be a promising approach to the development of efficient personalised cosmetic delivery platforms.
Multidisciplinary Management of Craniopharyngiomas in Children: A Single Center Experience
Authors: Del Baldo Giada , Vennarini Sabina , Cacchione Antonella , Amelio Dante , De Ioris Maria Antonietta , Fabozzi Francesco , Colafati Giovanna Stefania , Mastronuzzi Angela , Carai Andrea
Published: November 2022

Background: Craniopharyngioma (CP) is a rare brain tumor involving the sellar region. The best management is still debated. Gross total resection (GTR) is considered the best option to improve recurrence-free survival, but considerable long-term sequelae with a significant impact on quality of life have been reported. Subtotal resection followed by radiotherapy achieves similar disease control compared to GTR with less complications. Methods: We retrospectively reviewed 10 pediatric patients affected by CP treated with partial resection and subsequent proton therapy (PBT). We reviewed visual, endocrinological, and neuropsychological data at baseline, after surgery, and after radiation for all patients. Results: At the time of diagnosis, visual impairment was detected in 70% of patients and endocrinological abnormalities in 50%. All patients were subject to one or more surgical procedures. Surgery had no impact on visual status; however, it caused a worsening of endocrine function in half of patients. After surgery, all patients underwent PBT, achieving a partial response in 7 out of 10 patients (70%), while stable disease was observed in the other three patients (30%) at a median follow-up of 78 months from the end of PBT. Both visual and endocrine deficits were stable after PBT, with neurocognitive performance scores unchanged from baseline. Conclusions: A conservative surgical approach followed by PBT represents a safe and effective strategy to manage CP and limit long-term sequelae.
Bridging Digital Approaches and Legacy in Archaeology
Authors: Katsianis Markos , Kalayci Tuna , Sarris Apostolos
Published: November 2022

The emergence of the ubiquitous digital ecosystem has provided new momentum for research in archaeology and the cultural heritage domain [...]
Federated AI-Enabled In-Vehicle Network Intrusion Detection for Internet of Vehicles
Authors: Yang Jianfeng , Hu Jianling , Yu Tianqi
Published: November 2022

The integration of artificial intelligence (AI) technology into the Internet of Vehicles (IoV) has provided smart services for intelligent connected vehicles (ICVs). However, due to gradually upgrading to ICVs, an increasing number of external communications interfaces exposes the in-vehicle networks (IVNs) to malicious network intrusion. The malicious intruders can take over the compromised ICVs and mediately intrude into the ICVs connected through IoV. Therefore, it is urgent to develop IVN intrusion detection methods for IoV security protection. In this paper, a ConvLSTM-based IVN intrusion detection method is developed by leveraging the periodicity of the network message ID. For training the ConvLSTM model, a federated learning (FL) framework with client selection is proposed. The fundamental FL framework works in the client-server mode. ICVs are the local clients, and mobile edge computing (MEC) servers connected to base stations (BSs) function as the parameter servers. Based on the framework, a proximal policy optimization (PPO)-based federated client selection (FCS) scheme is further developed to optimize the model accuracy and system overhead of federated ConvLSTM model training. Simulations are conducted by the exploitation of real-world IoV scenario settings and IVN datasets. The results indicate that by exploiting the ConvLSTM, the model size and convergence time are dramatically reduced, and the 95%-beyond detection accuracy is maintained. The results also unveil that the PPO-based FCS scheme outperforms the benchmarks on the convergence rate, model accuracy, and system overhead.
Development of Voltage Control Algorithm for Improving System Stability in Korean Distribution Grids
Authors: Gwon DongYeong , Choi YunHyuk , Sim JunBo
Published: November 2022

Problems with overvoltage and reverse energy flow arise as the percentage of distribution energy resources (DERs) in distribution system rises. This paper implements a MATLAB/Simulink linked model that communicates with the OpenDSS engine. The point of common coupling (PCC) voltage typically mitigates using the inverter outputs control. However, case overvoltage issues occur in distribution networks and the influence of the volt–var control effect is insufficient to reduce PCC voltage to a stable range. To improve the reactive control effect, this paper proposes active power control and voltage error compensation methods that maximize the reactive power control effect. The DER management system (DERMS) platform was constructed to analyze the effect of changing DER output values. The DERMS data are organized based on real distribution line (D/L) system data where overvoltage occurred in Korea and the control effect of the real system is analyzed. This control method analysis can be used to develop an inverter control scheme for the over voltage issues described in this paper.
Preparation of Side-By-Side Bicomponent Fibers Using Bio Polyol Based Thermoplastic Polyurethane (TPU) and TPU/Polylactic Acid Blends
Authors: Oh Jiyeon , Kim Young Kwang , Hwang Sung-Ho , Kim Hyun-Chul , Jung Jae-Hun , Jeon Cho-Hyun , Kim Jongwon , Lim Sang Kyoo
Published: November 2022

In this study, side-by-side bicomponent fibers were prepared by melt spinning using bio-based thermoplastic polyurethane (TPU) and TPU/polylactic acid (PLA) blends. The morphology, thermal and mechanical properties of the fibers were investigated. To this end, the synthesis of TPU using biomass-based polyols and the preparation of TPU/PLA blends were preceded. Their morphological and structural characteristics were investigated. The synthesis of TPU was confirmed through Fourier transform infrared analysis, and as a result of gel permeation chromatograph analysis, a compound having a weight average molecular weight of 196,107 was synthesized. The TPU/PLA blends were blended in the ratio of 80/20, 60/40, 40/60, and 20/80 through a melt extruder. They formed a sea–island structure as a result of scanning electron microscope analysis, and an increase in the PLA content in the TPU matrix caused a decrease in the melt flow index. Finally, TPU/(TPU/PLA) side-by-side bicomponent fibers were prepared by utilizing the above two materials. These fibers exhibited tensile strengths of up to 3624 MPa, with improved biocarbon content of up to 71.5%. These results demonstrate the potential of TPU/(TPU/PLA) side-by-side bicomponent fibers for various applications.
Age, Growth and Population Structure Analyses of the Purpleback Flying Squid Sthenoteuthis oualaniensis in the Northwest Indian Ocean by the Statolith Microstructure
Authors: Ou Yu-Zhe , Lu Hua-Jie , Wang Hong-Hao , Chen Zi-Yue , Zhao Mao-Lin
Published: November 2022

A total of 1177 Sthenoteuthis oualaniensis were randomly collected from the northwest Indian Ocean from February between May 2019 and 2020 by lighting falling-net vessels. The age, growth, and population structure of S. oualaniensis were studied based on the statolith microstructure. The results showed that the range of mantle length (ML) was 123–562 mm for females and 88–273 mm for males, and the range of body weight (BW) was 78–6268 g for females and 82–518 g for males in 2019 and 2020, respectively. The hatching date extended from May to December, with the 2019 samples mainly composed of the autumn population, while the 2020 samples were mostly composed of the summer population. The analysis of covariance (ANCOVA) showed that there were significant differences in the growth of ML–age and BW–age between sexes. In the growth model of the ML–age relationship, both females and males in 2019 were best described by s linear model, and 2020 was best described by a logarithmic model. The growth model of the BW–age relationship of females and males in 2019 was best described as linear and the growth model of the BW–age relationship of females and males in 2020 was described logarithmically and exponentially, respectively. The average absolute daily growth rate (AGR) and instantaneous growth rate (IGR) for ML of the 2019 samples were 0.85 mm/d and 0.40%/d, and the average AGR and IGR for ML of the 2020 samples were 0.65 mm/d and 0.18%, respectively. The growth of S. oualaniensis samples in 2019 was faster than that in 2020. This study provided basic information on the age, growth, and population of S. oualaniensis, which will supply a scientific basis for stock assessment and sustainable development.
Impact of Apple Pomace Powder on the Bioactivity, and the Sensory and Textural Characteristics of Yogurt
Authors: Popescu Liliana , Ceșco Tatiana , Gurev Angela , Ghendov-Mosanu Aliona , Sturza Rodica , Tarna Ruslan
Published: November 2022

This study focused on the development of a yogurt with an improved structure, texture and antioxidant activity level, by using apple pomace (AP) powder that was obtained in large quantities during the production of juices. The objective was to determine the sensory, physicochemical, textural and antioxidant characteristics of yogurt with the addition of AP powder (0.2–1.0%), during its shelf life. The physicochemical composition of AP was determined as follows: dietary fibers—62.73%, including pectin—23.12%; and the content of the antioxidant compounds in AP—total polyphenols (728.8 mg GAE/100 g DW), flavonoids (246.5 mg QE/100 g DW), tannins (63.54 mg TAE/100 g DW), carotenoids (4.93 mg/100 g DW) and the ability to inhibit the free radical (2433 µmol TE/100 g DW). AP addition reduces the yogurt fermentation time. The increase in the total dietary fiber content of up to 0.63% and in the insoluble fiber of up to 0.14% was attested in this study, as well as a significant increase in antioxidant activity, which correlated to the AP content. The addition of AP improved the textural properties of the yogurt during storage (20 days) and led to a significant reduction in syneresis. The influence of the AP content and the storage period on the textural characteristics and the overall acceptability of the yogurt samples were analyzed by the mutual information method. The AP content greatly influenced the yogurt’s quality, with the information analysis value for the overall acceptability being 0.965 bits. The analysis of the sensory and textural parameters of the yogurt during storage (1–20 days) demonstrated that samples with AP in proportions of 0.6–0.8% were evaluated with the highest score.
Caco-2 Cell Response Induced by Peptides Released after Digestion of Heat-Treated Egg White Proteins
Authors: Benedé Sara , Pérez-Rodríguez Leticia , Molina Elena
Published: November 2022

The heat treatment of food proteins induces structural modifications that influence their interaction with human fluids and cells. We aimed to evaluate the Caco-2 cell response induced by peptides produced after digestion of heat-treated egg white proteins. In vitro digestion of ovalbumin (OVA), ovomucoid (OM), and lysozyme (LYS), untreated or previously heated, was performed. The digestibility of proteins and the response of Caco-2 cells exposed to peptides (<10 kDa) generated during digestion were evaluated. Intact OVA and LYS persisted after the digestion of native proteins, whereas OM was completely hydrolysed. A heat treatment at 65 °C for 30 min did not alter the digestibility of OVA, whereas at 90 °C for 3 min, protein degradation was favoured. The digestibility of OM and LYS was not affected by heat treatment. Peptides derived from OVA and OM digestion induced IL-6 and IL-8 production. OVA and LYS digestion promoted the expression of Tslp, and Il6 and Il33, respectively. A heat treatment prior to OVA digestion reduced IL-6 production and Tslp expression. It was concluded that heat treatments can reduce the release of OVA-derived peptides, but not OM and LYS, with proinflammatory activity during digestion.
ResNet Model Automatically Extracts and Identifies FT-NIR Features for Geographical Traceability of Polygonatum kingianum
Authors: Xu Yulin , Yang Weize , Wu Xuewei , Wang Yuanzhong , Zhang Jinyu
Published: November 2022

Medicinal plants have incredibly high economic value, and a practical evaluation of their quality is the key to promoting industry development. The deep learning model based on residual convolutional neural network (ResNet) has the advantage of automatic extraction and the recognition of Fourier transform near-infrared spectroscopy (FT-NIR) features. Models are difficult to understand and interpret because of unknown working mechanisms and decision-making processes. Therefore, in this study, artificial feature extraction methods combine traditional partial least squares discriminant analysis (PLS-DA) and support vector machine (SVM) models to understand and compare deep learning models. The results show that the ResNet model has significant advantages over traditional models in feature extraction and recognition. Secondly, preprocessing has a great impact on the feature extraction and feature extraction, and is beneficial for improving model performance. Competitive adaptive reweighted sampling (CARS) and variable importance in projection (VIP) methods screen out more feature variables after preprocessing, but the number of potential variables (LVs) and successive projections algorithm (SPA) methods obtained is fewer. The SPA method only extracts two variables after preprocessing, causing vital information to be lost. The VIP feature of traditional modelling yields the best results among the four methods. After spectral preprocessing, the recognition rates of the PLS-DA and SVM models are up to 90.16% and 88.52%. For the ResNet model, preprocessing is beneficial for extracting and identifying spectral image features. The ResNet model based on synchronous two-dimensional correlation spectra has a recognition accuracy of 100%. This research is beneficial to the application development of the ResNet model in foods, spices, and medicinal plants.
A Mechanistic Insight on Phytoconstituents Delivering Hypoglycemic Activity: A Comprehensive Overview
Authors: Raghav Shraddha Singh , Kumar Bhavna , Sethiya Neeraj Kumar , Kaul Ankur
Published: November 2022

Diabetes is a long-term (chronic), challenging lifestyle (metabolic) disorder in which the body cannot regulate the amount of sugar in the blood and majorly affecting endocrine system and metabolic functions. Its complications majorly affect the neurons (as developing neuropathy), kidney (as nephropathy), and eye (as retinopathy). Diabetes also results in other associated problems, such as diabetic foot ulcers, sexual dysfunction, heart diseases etc. In the traditional medicines, the search for effective hypoglycemic agents is a continuous and challenging approach. Plant-derived bioactives, including alkaloids, phenols, glycosides, anthocyanins, flavonoids, saponins, tannins, polysaccharides, and terpenes, have been established to target cellular and molecular mechanisms involved in carbohydrate metabolism. Numerous diabetic patients select the herbal or traditional medicine system as an alternative therapeutic approach along with the mainstream anti-diabetic drugs. However, due to restrictive hurdles related to solubility and bioavailability, the bioactive compound cannot deliver the requisite effect. In this review, information is presented concerning well researched phytoconstituents established as potential hypoglycemic agents for the prevention and treatment of diabetes and its associated disorders having restricted solubility and bioavailability related issues. This information can be further utilized in future to develop several value added formulation and nutraceutical products to achieve the desired safety and efficacy for the prevention and treatment of diabetes and its related diseases.
Hemostatic Cryogels Based on Oxidized Pullulan/Dopamine with Potential Use as Wound Dressings
Authors: Baron Raluca Ioana , Duceac Ioana A. , Morariu Simona , Bostănaru-Iliescu Andra-Cristina , Coseri Sergiu
Published: November 2022

The impetus for research into hydrogels based on selectively oxidized polysaccharides has been stimulated by the diversity of potential biomedical applications. Towards the development of a hemostatic wound dressing in this study, we creatively combined the (hemi)acetal and Schiff base bonds to prepare a series of multifunctional cryogels based on dialdehyde pullulan and dopamine. The designed structures were verified by NMR and FTIR spectroscopy. Network parameters and dynamic sorption studies were correlated with environmental scanning microscopy results, thus confirming the successful integration of the two components and the opportunities for finely tuning the structure–properties balance. The viscoelastic parameters (storage and loss moduli, complex and apparent viscosities, zero shear viscosity, yield stress) and the structural recovery capacity after applying a large deformation were determined and discussed. The mechanical stability and hemostatic activity suggest that the optimal combination of selectively oxidized pullulan and dopamine can be a promising toolkit for wound management.
Design and Validation of a Questionnaire to Measure the Perception of Nursing Degree Students about the Learning Process in Primary Care
Authors: Almazor-Sirvent Adrián , Miguel-Ruiz Maria Dolores , Huguet-Miguel Anna , Hurtado-Pardos Bárbara , Roldán-Merino Juan Francisco , Moreno-Arroyo María del Carmen , Biurrún-Garrido Ainoa , Garnacho-Castaño Manuel Vicente , Escofet Anna
Published: November 2022

The aim of this study was to develop a tool for the evaluation of the learning process of the clinical practicum in primary care. The study was carried out in two phases: (1) identification of the categories that determine the perception of the nursing degree students about the learning process in the clinical practicum in primary care and the items for each category; and (2) cross-sectional study in a sample of 475 nursing degree students. The psychometric properties in terms of reliability (internal consistency) and construct validity were analyzed through a confirmatory factor analysis. Cronbach’s alpha coefficient of internal consistency for the entire questionnaire was 0.93, and that for each of the categories was above 0.70 in all cases. The chi-squared test was statistically significant (2.84; p < 0.001). The confirmatory factor analysis produced a model of 6 dimensions and 41 items. The parameters were estimated through the least squares method. All saturations were statistically significant (p < 0.05). In view of the results of this study, it can be asserted that the questionnaire to measure the perception of the nursing degree students about the learning process in the community clinical practicum (QPCLP) presents good properties in terms of internal consistency and validity.
Analysis of Research Trends on Elbow Pain in Overhead Sports: A Bibliometric Study Based on Web of Science Database and VOSviewer
Authors: Li Wei Han , Hadizadeh Maryam , Yusof Ashril , Naharudin Mohamed Nashrudin
Published: November 2022

The publications on elbow pain (EP) in overhead sports are increasing. The results of previous studies mostly focus on the influence of EP in the ball game and throwing sports. Thus, a bibliometric analysis of these publications may show the direction of hot topics and future research trends. The purpose of this study is to identify the research trends on EP in overhead sports. For the methods, the first step is to use the main keywords of ‘Elbow pain’ and ‘Overhead sport’ merging auxiliary vocabulary to reach the relevant global publications between 1970 and 2022 in the Web of Science (WoS) database. The literature data set is imported into EndNote literature manager software to remove duplication. Secondly, the duplication-reduced articles are imported to an Excel sheet according to the inclusion and exclusion criteria of this study. In the third step, VOSviewer software is applied as the main analysis tool in extracting data for analysis from the articles. Then, the main research results for three aspects are obtained by VOSviewer software which extracted and analyzed the parameters of author name, article title, publication journal, keywords, organization, publication country/region, and the sum of times cited from 455 qualified papers. The study found that the United States of America made the most outstanding contribution to this theme study. The research on EP in overhead sports in China requires more attention from scholars. EP in swimming is a new research direction worthy of attention. In conclusion, the research results prove the growth trend of EP in overhead sports. The EP problem not only exists in the ball game and throwing sports but also swimming. Sport commercialization and the involvement of related professional sports organizations determine the degree of EP’s attention in a specific sport and the development of solutions. The development of a region or country also affects the depth and scope of EP study. Clinical research development and in-depth exploration are one of the bases to solve EP problems. Non-clinical action is beneficial to EP patients, but it still needs to be explored and studied.
The Network of Early Modern Printers and Its Impact on the Evolution of Scientific Knowledge: Automatic Detection of Awareness Relationships
Authors: Valleriani Matteo , Vogl Malte , el-Hajj Hassan , Pham Kim
Published: November 2022

This work describes a computational method for reconstructing clusters of social relationships among early modern printers and publishers, the most determinant agents for the process of transformation of scientific knowledge. The method is applied to a dataset retrieved from the Sphaera corpus, a collection of 359 editions of textbooks used at European universities and produced between the years 1472 and 1650. The method makes use of standard bibliographic data and fingerprints; social relationships are defined as “awareness relationships”. The historical background is constituted of the production and economic practices of early modern printers and publishers in the academic book market. The work concludes with empirically validating historical case studies, their historical interpretation, and suggestions for further improvements by utilizing machine learning technologies.
Abnormal Programmed Cell Death of Tapetum Leads to the Pollen Abortion of Lycium barbarum Linnaeus
Authors: Zhang Xin , Bei Zhanlin , Ma Haijun , Wei Zhaojun , Zhou Jun , Ren Yufeng , Xu Wendi , Nan Peng , Wang Yuguo , Li Linfeng , Zhang Wenju , Yang Ji , Zhong Yang , Song Zhiping
Published: November 2022

Programmed cell death (PCD) in tapetum provides nutrients for pollen development. Once this process becomes abnormal, the pollen will be aborted, and sterile lines will be formed. Lycium barbarum L. is a well-known medicinal and edible plant, and male sterile lines play an important role in the cultivation of its new varieties by utilizing hybrid vigor. However, the male sterility mechanism of L. barbarum is poorly understood. In this study, the main characteristic changes during the pollen development of L. barbarum sterile line (Ningqi No. 5) and fertile line (Ningqi No. 1) were compared through anatomical observation, physiological detection and gene expression analysis. Anatomical observation showed that compared with that of the fertile line, the tapetum of the sterile line persisted during pollen development, the organelle morphology and number of tapetal cells changed remarkably, and the PCD was remarkably delayed. Membranous peroxidation caused by reactive oxygen species (ROS) in the sterile line occurred from the late tetrad to the pollen grain stage, and that in Ningqi No. 1 transpired in the tetrad stage. This difference in the dynamic changes of ROS affected the redox balance of microspore development. qPCR detection of DYT1 and MS1 genes regulating tapetum development showed that compared with those in the fertile line, the expression levels of both genes in the sterile line changed significantly from pollen mother cell stage to pollen grain stage. This finding may be associated with the start-up delay of tapetal PCD. All these results suggested that abnormal tapetal PCD is an important mechanism leading to male sterility in L. barbarum.
Hospitals: A Journal Title with Many Meanings and One Vision
Authors: Oliva Antonio , Ozonoff Al , Caputo Matteo , Grassi Simone
Published: November 2022

“Hospitals” as a name for a journal might appear simply as an umbrella term for healthcare-relevant research [...]
Mining the Spatial Distribution Pattern of the Typical Fast-Food Industry Based on Point-of-Interest Data: The Case Study of Hangzhou, China
Authors: Zhou Yan , Shen Xuan , Wang Chen , Liao Yixue , Li Junli
Published: November 2022

There is a Chinese proverb which states “Where there are Shaxian Snacks, there are generally Lanzhou Ramen nearby”. This proverb reflects the characteristics of spatial clustering in the catering industry. Since the proverbs are rarely elucidated from the geospatial perspective, we aimed to explore the spatial clustering characteristics of the fast food industry from the perspective of geographical proximity and mutual attraction. Point-of-interest, OSM road network, population, and other types of data from the typical fast-food industry in Hangzhou were used as examples. The spatial pattern of the overall catering industry in Hangzhou was analyzed, while the spatial distribution of the four types of fast food selected in Hangzhou was identified and evaluated. The “core-edge” circle structure characteristics of Hangzhou’s catering industry were fitted by the inverse S function. The common location connection between the Western fast-food KFC and McDonald’s and the Chinese fast-food Lanzhou Ramen and Shaxian Snacks and the spatial aggregation were elucidated, being supported by correlation analysis. The degree of mutual attraction between the two was applied to express the spatial correlation. The analysis demonstrated that (1) the distribution of the catering industry in Hangzhou was northeast–southwest. The center of the catering industry in Hangzhou was located near the economic center of the main city rather than in the center of urban geography. (2) The four types of fast food were distributed in densely populated areas and exhibited an anti-S law, which first increased but then decreased as the distance from the center increased. Among these, the number of four typical fast foods was the highest within a distance of 4–10 km from the center. (3) It was concluded that 81.6% of KFCs had a McDonald’s nearby within 2500 m, and 68.5% of Shaxian Snacks had a Lanzhou Ramen nearby within 400 m. McDonald’s attractiveness to KFC was calculated as 0.928448. KFC’s attractiveness to McDonald’s was 0.908902. The attractiveness of the Shaxian Snacks to Lanzhou Ramen was 0.826835. The attractiveness of Lanzhou Ramen to Shaxian Snacks was 0.854509. McDonald’s was found to be dependent on KFC in the main urban area. Shaxian Snacks were strongly attributed to Lanzhou Ramen in commercial centers and streets, while Shaxian Snacks were distributed independently in the eastern Xiaoshan and Yuhang Districts. This study also helped us to optimize the spatial distribution of a typical fast-food industry, while providing case references and decision-making assistance with respect to the locations of catering industries.
Vulnerability Identification and Cascading Failure Spatiotemporal Patterns on Road Network under the Rainstorm Disaster
Authors: Wu Qirui , Han Zhigang , Cui Caihui , Liu Feng , Zhao Yifan , Xie Zhaoxin
Published: November 2022

Road vulnerability is crucial for enhancing the robustness of urban road networks and urban resilience. In medium or large cities, road failures in the face of unexpected events, such as heavy rainfall, can affect regional traffic efficiency and operational stability, which can cause high economic losses in severe cases. Conventional studies of road cascading failures under unexpected events focus on dynamic traffic flow, but the significant drop in traffic flow caused by urban flooding does not accurately reflect road load changes. Meanwhile, limited studies analyze the spatiotemporal pattern of cascading failure of urban road networks under real rainstorms and the correlation of this pattern with road vulnerability. In this study, road vulnerability is calculated using a network’s global efficiency measures to identify locations of high and low road vulnerability. Using the between centrality as a measure of road load, the spatiotemporal patterns of road network cascading failure during a real rainstorm are analyzed. The spatial association between road network vulnerability and cascading failure is then investigated. It has been determined that 90.09% of the roads in Zhengzhou city have a vulnerability of less than one, indicating a substantial degree of spatial heterogeneity. The vulnerability of roads adjacent to the city ring roads and city center is often lower, which has a significant impact on the global network’s efficiency. In contrast, road vulnerability is greater in areas located on the urban periphery, which has little effect on the global network’s efficiency. Five hot spots and three cold spots of road vulnerability are identified by using spatial autocorrelation analysis. The cascading failure of a road network exhibits varied associational characteristics in distinct clusters of road vulnerability. Road cascading failure has a very minor influence on the network in hot spots but is more likely to cause widespread traffic congestion or disruption in cold spots. These findings can help stakeholders adopt more targeted policies and strategies in urban planning and disaster emergency management to build more resilient cities and promote sustainable urban development.
Rate and Risk Factors of Acute Myocardial Infarction after Debut of Chronic Kidney Disease—Results from the KidDiCo
Authors: Kampmann Jan Dominik , Heaf James Goya , Mogensen Christian Backer , Petersen Sofie Ronja , Wolff Donna Lykke , Mickley Hans , Brandt Frans
Published: November 2022

Chronic kidney disease (CKD) is a known risk factor for cardiovascular disease, including acute myocardial infarction. However, whether this risk is only associated with severe kidney disease or is also related to mildly impaired kidney function is still under debate. The incidence rate and risk factors of incident acute myocardial infarction (AMI) in patients with CKD are sparse. Potential differences in risk factor profiles between CKD patients with incident AMI and CKD patients with a prior AMI have not been sufficiently investigated. Furthermore, important factors such as albuminuria and socio-economic factors are often not included. The primary aim of this study was to establish the incidence rate of AMI after CKD debut. Secondly, to evaluate the importance of different CKD stages and the risk of having an AMI. Finally, to identify individuals at risk for AMI after CKD debut adjusted for prevalent AMI. Based on data from the kidney disease cohort of Southern Denmark (KidDiCo), including 66,486 CKD patients, we established incidence rates and characteristics of incident AMI among patients within a 5-year follow-up period after CKD debut. A Cox regression was performed to compute the cause-specific hazard ratios for the different risk factors. The incidence rate for CKD stage G3–5 patients suffering acute myocardial infarction is 2.5 cases/1000 people/year. In patients without a previous myocardial infarction, the risk of suffering a myocardial infarction after CKD debut was only significant in CKD stage G4 (HR = 1.402; (95% CI: 1.08–1.81); p-value = 0.010) and stage G5 (HR = 1.491; (95% CI: 1.01–2.19); p-value = 0.042). This was not the case in patients who had suffered an acute myocardial infarction prior to their CKD debut. In this group, a previous myocardial infarction was the most critical risk factor for an additional myocardial infarction after CKD debut (HR = 2.615; (95% CI: 2.241–3.05); p-value < 0.001). Irrespective of a previous myocardial infarction, age, male sex, hypertension, and a low educational level were significant risk factors associated with an acute myocardial infarction after CKD debut. The incidence rate of AMI in patients with CKD stage G3–5 was 2.5 cases/1000 people/year. Risk factors associated with incident AMI in CKD stage G3–5 patients were CKD stage, age, and hypertension. Female sex and higher educational levels were associated with a lower risk for AMI. Prior AMI was the most significant risk factor in patients with and without previous AMI before fulfilling CKD stage G3–5 criteria. Only age, sex, and a medium-long educational level were significant risk factors in this group.
Post-Intensive Care Syndrome in Non-COVID-19 ICU Survivors during the COVID-19 Pandemic in South Korea: A Multicenter Prospective Cohort Study
Authors: Kang Jiyeon , Hong Jiwon , Jeong Jin-Heon
Published: November 2022

A prospective observational cohort study investigated the prevalence of post-intensive care syndrome (PICS) among non-COVID-19 ICU survivors during the COVID-19 pandemic. Adults who had been admitted to the ICU for more than 24 h were enrolled, and followed-up at 3, 6, and 12 months post-discharge. PICS (mental health, cognitive, and physical domains) was measured using the Hospital Anxiety and Depression Scale, Posttraumatic Diagnosis Scale, Montreal Cognitive Assessment, and Korean Activities of Daily Living (ADL) scale. Data were analyzed from 237 participants who completed all three follow-up surveys. The prevalence of PICS was 44.7%, 38.4%, and 47.3%, at 3, 6, and 12 months of discharge, respectively. The prevalence of PICS in the mental health and cognitive domains decreased at 6 and increased at 12 months. The prevalence of PICS in the physical domain declined over time. Changes in PICS scores other than ADL differed significantly according to whether participants completed follow-up before or after December 2020, when COVID-19 rapidly spread in South Korea. In the recent group, anxiety, depression, post-traumatic stress disorder, and cognition scores were significantly worse at 12 months than at 6 months post-discharge. The COVID-19 pandemic may have adversely affected the recovery of non-COVID-19 ICU survivors.