bluuebunny/crossref_metadata_2025 huggingface dataset:
Ecological desalination of anchovy residues and their mixture with soybean meal for the production of poultry feed: Optimization of waste through response surface methodology (RSM)
Authors: BOUMENDIL Ilham , SISOUANE Mhammed , EL HAIMER Youness , BOUNOUAR Nabil , KHAMLICH Jihane , BAGGAR Asmae , SAFI Amal
Published: December 2023

Salted anchovy bones are a non-recyclable waste product containing high salt levels. However, they also contain valuable minerals such as calcium, phosphorus, potassium, magnesium, and nitrogen. This study aimed to find a cost-effective method to desalinate anchovy bones while preserving their nutritional value and repurposing them as a raw material for poultry feed. Through various tests, we were able to reduce the salt content of the anchovy bones from 15.4% to 4.7% using a 50/50 percent mixture of tap water and from 15.4% to 3.7% using a mixture of tap water and soybean meal in a 30/70 percent ratio. Combining soybean meal with desalted anchovy bones resulted in a nutritional composition comparable to that found in poultry feed, reducing salt content. The response surface method (RSM) was employed to determine the optimal proportions of desalted anchovy bones (70-90%) and soybean meal (10-30%) and to study the variables affecting the concentrations of NaCl, Ca, P, Ash, and TNM. The study revealed the influence of desalted anchovy bone and soybean meal percentages on these concentrations. This study demonstrates that the method used provides an ideal approach for understanding the interactions between input parameters (% DAR, % SM) and output parameters (NaCl, Ca, P, Ash, and TNM) and shows promising results for the desalination of anchovy bones using a soybean meal cake as well as the feasibility of creating poultry feed.
Direct Detection of MiRNAs miR-34a, -145, and -218 with CRISPR/Cas13a-nuclease
Authors: Timoshenko O.S. , Kurbatov L.K. , Khmeleva S.A. , Ptitsyn K.G. , Radko S.P. , Lisitsa A.V.
Published: December 2023

Using CRISPR/Cas13a-nuclease we have demonstrated a feasibility of direct detection of three miRNAs, miR-34a, -145, and -218 (their molecular signature is suggested as a diagnostic and prognostic biomarker in cervical cancer),. The detection is based on registration of a cleavage of molecular reporters bearing a fluorophore and a quencher by the complex of CRISPR/Cas13a-nuclease and guide RNA (gRNA) with a spacer of 21-23 nucleotides long. The detection sensitivity varied among miRNAs tested by 10-fold, presumably due to the unwanted intramolecular partial base paring of gRNA. The miRNA detection with Cas13a nuclease strongly depended on the presence of background RNA thus potentially compromising its direct application to complex media in a general case. Further optimization of measurement conditions including probably an additional amplification of the signal generated by collateral activity of Cas13a nuclease is necessary to directly detect miR-34a, -145, and -218 in biological samples.
Influence of Adding cRGD Peptide to Phospholipide Nanoparticles with Doxorubicin Included on Apoptosis in Glioblastoma Cells in Vitro
Authors: Kostryukova L.V. , Tereshkina Yu.A. , Gisina A.M. , Bedretdinov F.N. , Pyatigorsky A.M.
Published: December 2023

One of the methods of treating glioblastoma after surgery is chemotherapy; the drugs used in this case, due to their nonspecific distribution, lead to a number of complications. One way to overcome this drawback is to supply drugs with delivery systems with targeted molecules. This approach allows increasing the accumulation of therapeutic agents directly at the lesion site, minimizing side effects. This work is a continuation of the study of the mechanism of action of the previously obtained phospholipid composition of doxorubicin with a targeted cRGD peptide (NPh- Dox-cRGD). This peptide is capable of selectively interacting with integrin ?v?3, a receptor expressed on the surface of a number of tumor cells, including glioblastoma. The work assessed the cytotoxic effect of the NPh-Dox-cRGD composition in comparison with the free substance (Dox) and embedded in phospholipid nanoparticles without a targeted ligand (NPh-Dox). It was shown that after 24 h of incubation of U-87 MG cells with substances at the maximum concentration of Dox (30 ?g/ml), the percentage of viability cells was 6% for Dox, 21% for NPh-Dox-cRGD, and 21% for NPh-Dox � 17%, i.e. When Dox was incorporated into phospholipid NPs, its cytotoxic effect was observed to a lesser extent. No statistically significant differences were noted in the control line HeLa. Assessment of tumor cell death using flow cytometry indicated that most of the cells died via apoptosis. When incubated with a composition containing a targeting peptide, NPh-Dox-cRGD, at a concentration (Dox) of 0.5 ?g/ml, the percentage of cells susceptible to late apoptosis was 29.7%, for the free form � 24.4%. An assessment of cells susceptible to early apoptosis (Dox concentration 0.5 ?g/ml) showed that the percentage of these cells for the sample with the peptide was higher and amounted to 11.4%.
A study on high sensitive C-Reactive protein as a diagnostic marker in preschool asthmatics
Authors: Murmu Mangal Charan , Majhi Subas Chandra , Nayak Himansu , Kiro Sameer , Das Swagat , Meher Shitanshu Kumar , Panda Sanjukta
Published: December 2023

: Childhood asthma has a hazardous impact on the growth, social & emotional aspect of the life thereby affecting the quality of life. Hence, early diagnosis & identification of symptoms can help prevent the co-morbidities. High sensitive C-Reactive protein (hsCRP) a known marker of systemic inflammation is evaluated in the current study as a marker of asthma in the preschool children.

To evaluate the efficacy of serum hsCRP as a diagnostic marker & to find out the correlation of serum hsCRP level among the different grades of severity of asthma in pre-school children.

A cross-sectional analytical study was designed with 811 samples equally divided between the case & health matched control groups.GINA-2018 definition was used to recruit subjects & classify the severity. One time serum hsCRP was estimated in the subjects among both the cases & controls, & correlated with other variables in the study.

A total of 811 participants were included in the final analysis with 402participants in asthmatics category & 409 participants in healthy children category. Out of the 402 asthmatics,362 (90.05%) subjects tested to be positive(higher than 3mg/L) & only 40 subjects (9.95%) were negative. Similarly out of 409 healthy subjects, only 36 (8.8%) were positive while majority i.e. 373(91.2%) were found to be negative. The test was evaluated to be having a sensitivity of 90.05%, specificity of93.32% with a diagnostic accuracy of 91.66%. The diagnostic accuracy of hsCRP in severe asthma was 63%, & the specificity was 58%, whereas in case of mild asthma it was79% & 73% respectively with statistical significance.

hsCRP is a reliable diagnostic marker in preschool asthmatics to besides clinical correlates.
Mycological profile of subcutaneous skin biopsy samples in suspected subcutaneous mycosis, Are we missing some fungi? A tertiary care hospital based study
Authors: Rishi Saqib , Farooq Shaika , Farooq Tabinda
Published: December 2023

Subcutaneous mycosis includes a heterogeneous group of fungal infections that develop at the site of transcutaneous trauma. A rise in surviving population of individuals with co-morbidities together with lapses in infection control practices especially in rural India has led to emergence of myriad species of fungi causing such infections in recent years. This poses a diagnostic challenge to the clinicians. We therefore felt a need to study the mycological profile of subcutaneous tissue biopsies suspected of fungal etiology in our hospital setup.

This was a Retrospective cross-sectional observational study conducted for a period of 4 years from Jan 2015 to Jan 2019 in the Department of microbiology, Government medical College Srinagar. A total of 148 specimens of subcutaneous tissue biopsies of patients suspected of localized fungal Infection were processed by microscopy and culture for fungi.

Among a total of 148 subcutaneous tissue biopsy samples 76 (51%) were positive for fungi on KOH and culture. Mycological profile revealed that majority of fungi were Dermatophytes (n=22; 29%) and Yeasts (n=21; 28%). Third most common causative fungi isolated were Chromoblastomycetes (n=8; 11%), Phaeohyphomycetes (n=8;11%) and Aspergilli (n=8;11 %) comprising, A.fumigatus (n=11) and A.terreus (n=03), followed by Hyalohypomycetes (n=4;5%), sporotrichosis (n=3;4%) and Zygomycetes (n=4 ;5.3%).

: Dermatophytes and yeasts are emerging subcutaneous fungal infections. Active surveillance for all types of fungal infections should be done at all levels to address knowledge gaps that exist in etiology, pathogenesis and manifestations of fungal diseases of skin and subcutaneous tissue.
Anthropometric study of the bicipital groove in Kolkata based population and its clinical implication
Authors: Sengupta Oyndrila , Chaudhuri Srijit Narayan , Paul Mithu , Halder Subhajit
Published: December 2023

The knowledge of the humeral morphology is an important tool in determination of the prosthetic size, its positioning and also its design. Reconstructive surgery of upper end of humerus requires measurement of intertubercular sulcus.

In this descriptive and cross sectional study it was attempt to study the clinical correlation of length, depth and width of the bicipital groove with antero-posterior and transverse diameters of surgical neck of the dry humeri, for their use in the betterment of human humeral prosthesis.

The study was conducted on 100 adult dry intact human humerii collected from different medical colleges of Kolkata in the department of Anatomy, Calcutta National Medical College, Kolkata.

This study analysis was done in SPSS 23 Software. Independent sample-‘t’ test was used for statistical analysis. P-value <0.05 was considered to be significant.

The difference of anthropometric dimensions of left humeral bicipital groove are more significant as compared to right. There is strong statistical correlation between length of Bicipital Groove vs Total Length of Humerus, Width of Bicipital Groove vs. Transverse Diameter at surgical neck

To conclude, with minor differences from previous similar studies the present study is noteworthy in the field of prosthetic limb manufacture.
To determine the various causes of thrombocytopenia and its clinical correlation with bleeding in children and adolescents
Authors: Mishra Gyanesh , Dwivedi Rinu
Published: December 2023

Thrombocytopenia refers to a reduction in platelet count below 1,50,000/cumm. It is the most common cause of defective primary hemostasis that can lead to significant bleeding in children.

It was a retrospective observational study conducted in a tertiary care hospital in Bhilai, chattisgarh between Augusts to December 2021. Data collection was done from Sept 2018-Sept 2019. The aim of present study was to determine the various causes of thrombocytopenia in children and adolescents and to correlate its severity with etiology and risk of bleeding. Total 112 patients were included from age group 1y-18 yrs.

Out of total 112 patients 59 were males and 53 were females. 27 patients were 1-5 years of age, 30 patients were 6-12 years of age and55 were 13-18 years. The mean platelet count in my study was 68,340/cumm with a minimum of 4000/cumm. Bleeding was present in total 19 (16.9%) patients. The main bleeding manifestations were petechie or purpurae, epistaxis, ecchymosis, gastrointestinal bleed and others. Severity of thrombocytopenia correlates significantly with risk of bleeding (The p-value is 0.001**). The most common cause of thrombocytopenia in 69 patients with fever were infective and 43 patients without fever it was vitamin b12 deficiency. Severity of thrombocytopenia (p=0.0528) and bleeding (p=0.121) in patients with fever and without fever was not significant.

Thrombocytopenia in pediatric and adolescent children is caused by both infective and non infective illness. It mainly presents with cutaneous bleeds and mucosal bleeds. Severity of thrombocytopenia is significantly correlated with bleeding.
Prevalence of thrombocytopenia among Indian patients who are on chemotherapeutic drugs in five cities of India: A cross sectional descriptive study
Authors: Verma Mahendra Kumar , Malik Parmila , Khattri Jyotsana , VG Veeresh , Khajuria Atul , Singh Lalit
Published: December 2023

Chemotherapeutic drugs are chemical drugs used in management of cancer, these drugs are chemotoxic and has varied number of adverse effects. Thrombocytopenia is one such adverse effect, thrombocytopenia is the condition in which the platelets counts are less than few lakhs and cause the symptoms of the bleeding. The present study desiged to find the prevalence of thrombocytopenia among Indians who are on chemotherapeutic drugs.

: a descriptive cross section survey design used to identify the prevalence rate of thrombocytopenia among patients who are on chemotherapeutic drugs in India the cities studied are Lucknow 268 patients, Panipath 357 patients, Sonipath 384 patients, Gohana 291 patients, Delhi 445 patients, a total 1745 patients were under chemotherapeutic drugs of which 281 patients developed thrombocytopenia, in the samples collected analyzed at various selected diagnostic centers.

: The present study found that in Lucknow for 268 patients on chemotherapy 37 patients samples developed thrombocytopenia, Panipath for 357 patients on chemotherapy 76 patients samples developed thrombocytopenia, Sonipath for 384 patients on chemotherapy 68 patients samples developed thrombocytopenia, Gohana for 291 patients on chemotherapy 32 patients samples developed thrombocytopenia and in Delhi for 445 patients on chemotherapy 68 patients samples developed thrombocytopenia respectively. The overall prevalence of thrombocytopenia among patients who are on chemotherapeutic drugs is 16.01%.

chemo drugs are vital in management of cancer conditions, these drugs are best currently known in reducing or killing the cancer cells, however they also carry a bag of adverse effects which hampers the wellbeing of patients hence, the knowledge and prevalence rate of thrombocytopenia in patients under chemotherapy plays a vital role in primordial prevention and better management of thrombocytopenia in its occurrence.
Evaluation of neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) as inflammatory markers in patients with type 2 diabetes mellitus
Authors: Pandit Vidyanand , Sharma Dharmveer , Jain Vivek Kumar , Tyagi Shashsank
Published: December 2023

Diabetes Mellitus (DM), chronic metabolic disease and its complications are diabetic nephropathy, retinopathy, and neuropathy. Systemic inflammation play a significant role and could lead to insulin resistance. This study aimed to investigate NLR and PLR in T2DM patients in comparison with healthy controls.

This prospective study, conducted in SRVS Government Medical College, Shivpuri, Madhya Pradesh, India. In this study, a total of 220 subjects were involved, among them 110 were T2DM patients were cases and 110 healthy subjects were controls. Demographic details, physical and clinical examination were done for all the study subjects. Under aseptic conditions, five ml of fasting venous blood sample was collected and aliquoted into plain (3ml) and EDTA (2 ml) tubes and allowed to clot and centrifuged at 3000 rpm for 10 minutes. The obtained serum sample was used for the estimation of fasting and post-prandial glucose, renal profile, lipid profile using commercially available autoanalyzer kits. Whole blood sample was used for the Complete Blood Count (CBC) in EDTA vials. Neutrophil to Lymphocyte Ratio (NLR) and Platelet to Lymphocyte (PLR) were calculated. Whole blood sample was used for the estimation of HbA1c and BMI was calculated.

The variables were represented in Mean±SD. Categorical variables were represented in percentage. Spearman’s correlation was applied. The p value <0.05 considered as significant.

In the current study, mean age 60.2±4.2 yrs, BMI 27.1±2.4 (kg/m), Systolic blood pressure 132.1±12.3 mmHg, Diastolic blood pressure 90.2±10.5 mmHg, fasting blood sugar (FBS) 169.7±19.3 mg/dl, Post-Prandial blood sugar 238.1±39.5 mg/dl, HbA1c 7.9±0.8 %, Serum Urea 36.1±7.1 mg/dl, Creatinine 1.0±0.3 mg/dl, UA 6.5±2.3 mg/dl, Serum Total Cholesterol 241.1±30.5 mg/dl, Serum Triglycerides 170.0±16.2 mg/dl, Serum low density lipoprotein cholesterol (LDLC) 176.4±35.2 mg/dl, Serum very low density lipoprotein cholesterol (VLDL) 34.1±3.2 mg/dl, Lymphocytes 17.2±4.1 %, NLR 6.7±2.3 and PLR 19.1±6.9 were significantly increased in Type 2 Diabetes Mellitus (T2DM) cases whereas high low density lipoprotein cholesterol (HDLC) 30.7±3.9 mg/dl was significantly decreased in T2DM cases.

The present study results may conclude that increased NLR and PLR may be used as a markers for inflammation in T2DM. These may serve as an alternative to the other costly inflammatory markers.
Forecasting of neonatal mortality trend at a special new-born care unit in Odisha, India: A time-series analysis
Authors: Biswal Ramesh Kumar , Das Siba Prasad , Mishra Kaushik , Pradhan A
Published: December 2023

New born mortality is a public health problem in the state of Odisha. Newborn mortality is a dynamic process and variations in mortality are observed temporally and seasonally, and also across health facilities. Prior knowledge of mortality burden can enable health system’s readiness in terms of resources allocation and timely intervention, thereby improving the chances of survival of sick newborns admitted in the hospitals. Hence, this study aimed to examine temporal trends of newborn mortality in a Special Newborn Care Unit of Saheed Laxman Nayak Medical College and Hospital (SLNMCH) in Odisha and forecast a short-term monthly projection.

The Box-Jenkins approach was used to fit a seasonal autoregressive integrated moving average (SARIMA) model to the monthly recorded mortality among the hospitalized new borns in the SNCU during 2016-2020. The best-fit model for forecasting was found based on the Akaike Information Criterion.

The time-series analysis revealed a modest upward trend in newborn mortality rate among SNCU admitted newborns, with peaks in the late winter and late summer months. The seasonal ARIMA (0,1,1)(1,1,1)12 model offered the best fit for time-series data. This model predicted the monthly percentage of mortality in SNCU admitted newborns in the range of 9% to 35% with respective 95% confidence interval for two years period (2021-2022).

SARIMA models are useful for monitoring newborn mortality and provide an estimate of temporal trends and seasonality. The models are helpful for predicting occurrence of mortality in the SNCU of SLNMCH and could be useful for developing early warning systems. It may help in early detection, timely treatment, and prevention of serious complications in admitted sick newborns.
A clinicopathological study of fungal diseases in patients with chronic rhinosinusitis and sinonasal polyposis
Authors: Edward I Mathew Jackson , Sureshkumar S , Pandian D Rajkamal , Ganapathy S
Published: December 2023

Chronic Rhinosinusitis (CRS) is a ubiquitous medical condition that has both individual and financial impacts, severely affecting the quality of life. A fungus instigated CRS is fungal rhinosinusitis (FRS) is becoming increasingly incident in recent years. However, the lack of knowledge in the etiology, pathogenesis, and natural history of the FRS complicates the disease management plan.

: To study the prevalence of Fungal Diseases in all cases of Sinonasal polyposis and chronic rhino-sinusitis admitted for Functional Endoscopic Sinus Surgery

: This research focuses on the clinical, microbiological, and radiological analysis of FRS patients for two years. Age, gender, and occupational categorization of FRS patients were done and assessed the risk factors were based on sinus involvements based on radiology and systemic diseases.

: The incidence of FRS in 156 patients was higher in males within the age group of 30-40 (28%) and lower economic groups (38%). Symptoms like nasal obstruction (85%) and headache (56%) were predominantly observed. The involvement of multiple sinuses was confirmed through radiology studies. Microbiological tests revealed fungi in 18 samples (11.5%) through direct culture results and potassium hydroxide mount culture study. While Aspergillus genus pre-dominated etiological identification, A. flavus was more common in occurrence (65%), owing to the environment and living conditions that favor the exposure of spores. A recurrence study post-study period came up negative.

: A detailed pathophysiological analysis could improve the understanding of the disease prognosis that could avoid developing complications and indiscreet administration of antibiotics, thereby improving the quality of life.
Study of self- stigma and self -esteem in patients with anxiety and depression
Authors: Sachdev Sahiba Deepinder , Gawande Sushil , Faye Abhijeet , Bhave Sudhir , Kirpekar Vivek , Rahul Tadke
Published: December 2023

: Self -stigma occurs when a person accepts the negative attitude towards them, then internalize and apply belief to themselves. Self-esteem is individual’s subjective evaluation of their own worth. Self-stigma and self-esteem affects a person’s perception about themselves and the society surrounding them which plays an important role in treatment. It is most commonly affected in people diagnosed with psychiatric disorders.

The aim was to study self-stigma and self-esteem in patients with anxiety and depression.

After permission from Institutional ethics committee, semi-structured proforma, Internalized Stigma of Mental Illness Inventory-9 and Rosenberg’s Self Esteem Scale was used to assess 50 consecutive participants diagnosed with anxiety and depression according to DSM-5 criteria. Participants satisfying the inclusion and exclusion criteria were included in the study. The data collected was tabulated and analysed statistically and results and conclusions were drawn by using chi-square test, a p-value of <0.05 was considered significant.

Mean age of participants was 38.88 years with 64% females, majority being married, predominantly from urban background having education of at least secondary school certificate.19 participants were diagnosed with anxiety while 31 had depression.56% of the participants had high self-stigma and 54% participants had low self-esteem. There wasn’t any significant difference in percentages of high self-stigma and low self-esteem when compared between anxiety disorders and in depression. There were no significant socio-demographic or clinical correlates relating to self- stigma and self-esteem according to this study.

It was observed that both high self-stigma and low self-esteem was significantly high in psychiatric patients. It was seen that low self- esteem was associated with high self-stigma and high self-esteem was associated with low self-stigma. Hence, steps must be taken to psycho-educate the patient and their family members in order to reduce self-stigma and help in increasing their self-esteem.
An observational study to determine relationship of serum hydrogen sulphide level in hypothyroid patients in a medical college in Kolkata
Authors: Saha Pinaki , Bhattacharya Ankita , Banerjee Sadajit , Bhattacharyya Ipsita , Sanyal Debmalya , Biswas Indira Bhaskar
Published: December 2023

Hypothyroidism is an endocrinopathy eventuate due to destruction of thyroid cells incapacitating synthesis of thyroid hormones. HS which is a gas signaling molecule that might protect synthesis and secretion of thyroid hormone by upregulating the expression levels of thyroid hormone synthesis-related proteins and promotingting Thyroid peroxidase (TPO) activity through S-sulphydration of sirtuin-1 (SIRT-1). Depending on this fact we measured the HS level in a group of hypothyroid patient. The plasma H S level in case in our study was 33.95 ± 4.14 micromol/l with the range from 27.82 to 43.94 micromol/l. This was significantly (P< 0.001) lower than age/sex matched healthy controls which was 64.67±4.25 micromol/l, with a range from 49.81 to 80.02 micromol/l. this study also elucidated that plasma HS levels were significantly correlated with level of diagnostic parameters of hypothyroidism.
An atypical presentation of Covid 19 infection with isolated acute abdominal pain: A case report and review of the literature
Authors: Rani Khushboo , Narayan  , Kumar Sanjeet
Published: December 2023

Coronavirus illness (Covid-19) is an associate degree infectious disease caused by a newly discovered coronavirus. Patients often present with respiratory symptoms (cough, breathing difficulty) and fever. However, patients with Covid-19 have also been presented with gastrointestinal symptoms like abdominal pain, nausea, and vomiting, but are very unusual and often correlated with other symptoms. In our emergency department, we have a patient with atypical presentation of severe pain in the abdomen as the primary complaint without having any other gastrointestinal complaints but coronavirus infection.
Deficiencia de micronutrimentos. Circunstancia actual en la vida temprana y su repercusión en la salud y la economía
Authors: Perea Martínez Dr. Arturo , Rios G Paul T. , Parra Mercedes Macias , Bravo Lindoro Amalia Guadalupe , Pecero Hidalgo María Jose , Santiago Lagunes Lilia Mayrel , Gomez Ulises Reyes , Villanueva Clift Hector , Perea Caballero Aranza Lilian
Published: December 2023

El concepto de la "cuádruple carga de malnutrición" se refiere a la coexistencia aislada o combinada de cuatro desafíos en el ámbito de la nutrición humana: l) desnutrición energético-proteica, 2) obesidad, 3) malhidratación y 4) deficiencia de uno o varios micronutrimentos. La deficiencia de micronutrimentos, también llamada “hambre oculta” o micronutrimentopenia, representa un problema de salud en todo el mundo, porque repercute negativamente en el desarrollo, bienestar físico y mental, productividad y potencial desarrollo a una mejor calidad de vida. A diferencia de la desnutrición, los efectos en la salud derivados de la deficiencia de micronutrimentos suelen pasar inadvertidos o tener baja expresión y frecuentemente son subestimados. La Organización Mundial de la Salud (OMS) estima que más de 2 mil millones de individuos padecen deficiencia de micronutrimentos en todo el mundo. Esta problemática es especialmente común en las economías de ingresos bajos y medios, y afecta particularmente a las mujeres embarazadas y a los infantes. El objetivo de este estudio es revisar la evidencia científica relacionada con la deficiencia de micronutrimentos (micronutrimentopenia), cómo afecta en la vida temprana y su repercusión en la salud y la economía, por lo que se propone informar la trascendencia epidemiológica de estas carencias a nivel mundial y nacional, su efecto biológico y económico, así como las oportunidades de acción.
Enfermedad inflamatoria intestinal de inicio muy temprano con mutación en el gen fosfolipasa gama 2 (PLCG2) y defectos de la inmunidad
Authors: RAMIREZ - RISTORI ALFONSO GILBERTO , Delgado Celso Tomas Corcuera , Gutierrez Mendez Francisco , Lugo Reyes Saul Osvaldo , Yamazaki-Nakashimada Marco Antonio
Published: December 2023

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On the development of approaches to system safety assessment in the design of technical systems
Authors:   Department on nuclear and radiation safety of the Ministry of emergency situations of the Republic of Belarus, Lobach D.J.
Published: December 2023

The purpose of the study is to develop analytical approaches for the comparative assessment of technical systems in the implementation of expert activities. In the course of the research, priority directions for the selection of quantitative demonstration indicators of devices and technologies, and recommendations for choosing strategies for expert work when conducting assessments of technical systems security have been identified. A factual approach has been developed for relative (rating) comparison of designed, planned or applied technologies without the use of experimental data in the absence of operational experience. New opportunities for expanding expert assessments and analysis of equipment designs and technological solutions are shown. Their novelty lies in the application of the approaches of the safeometrics developing concept and consists in the use of plausible patterns for quantitative assessment of the parameters contained in the design and technical documentation and characterizing technical systems and complexes. Data for analysis can be prepared (collected) by experts or designers based on the requirements and recommendations of experts.
GO@dopamine-Cu as a Green Nanocatalyst for the Efficient Synthesis of Fully Substituted Dihydrofuran-2(5H)-ones
Authors: NIKNAM Neda , NOROOZİ PESYAN Nader
Published: December 2023

A new nanocatalyst graphene oxide@dopamine-Cu was synthesized, and its structure was characterized by fourier transform infrared (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), Energy Dispersive X-ray Spectrometry (EDX), and thermogravimetric analysis – differential thermal analysis (TGA-DTA) techniques. The three-component one-pot reaction between an arylamine, aromatic aldehyde, and acetylenic carboxylate was achieved and formed methyl 5-oxo-2-aryl-4-(arylamino)-2,5-dihydrofuran-3-carboxylate derivatives (4) in the presence of the catalytic amount of graphene oxide@dopamine-Cu nanocatalyst in high yield. Molecular structures of products were characterized by FT-IR, 1H, 13C nuclear magnetic resonance (NMR), and Mass spectroscopy techniques. Representatively, the mass fragmentation of 4a was discussed, and the structure was confirmed. Easy reaction, high performance, and easy catalyst recyclability are the main advantages of this work. This nanocatalyst is recycled up to five successive runs.
Selective Collection Of Solid Waste Using An Application – Carcará Software Proposal
Authors: MONTEIRO DA SILVA ENÉIAS , ALMEIDA BATALHA RODRIGUES RAFAEL ALLAN , DO SOCORRO FERREIRA PINHEIRO ANTÔNIO
Published: December 2023

The article contributes to the achievement of the Sustainable Development Goals (SDG) based on information Technology (IT) and the proper use of industrial property rights for their protection. The prototype in the form of an application helps to identify selective collection points and monitors the process of disposal of Recyclable Urban Solid Waste produced in the municipality of Santarém - PA. From a research with a qualitative, exploratory and descriptive approach based on the collection of data from the platform of the Instituto Nacional da Propriedade Industrial (INPI), using the following keywords: selective collection, solid and recyclable waste, added to the concept of information Technology and urban solid waste. In summary, we sought to identify software records related to SDG target 12.5 of the UN 2030 Agenda for Sustainable Development. This research served as a sample for the creation of a technological solution, generated in the conceptual presentation of the “Carcará” application, as a software that contributes to the selective collection of urban solid waste.
Tolerance Learning in Islamic Religious and Character Education Textbooks
Authors: Mawadda Mita , Supriadi Udin , Anwar Saepul , Abbas Hafizh Muzhaffar
Published: December 2023

Islamic Religious and Character Education (hereafter PAI) textbooks are part of an important means of teaching character values, including tolerance. Some cases of intolerance are still common in Indonesia and are even associated with Islamic religious education in schools. Therefore, there is a need to review Islamic religious education in schools. This study examines the PAI materials that include tolerance learning in Islamic religious education textbooks at the 7th, 8th, and 9th grade junior high school levels. This research is important so that in the future, tolerance learning materials can be provided to students in accordance with the portions. This study uses a literature review with a qualitative approach that analyzes the content of Islamic Religious and Character Education textbooks published by the Ministry of Education and Culture of the Independent Curriculum (7th and 8th grade books) and the Revised 2013 Curriculum (9th grade books). The data obtained are then collected and analyzed using the content analysis method. The data analysis techniques in this study used 3 data analysis steps, namely: data reduction, data display, and data verification. This study shows whether there is tolerance learning in Islamic Religious Education and Character Education textbooks or not. The results of the study show that the Islamic Religious Education and Character Education textbooks at the junior high school level strongly promote tolerance.
Elevated CO2 and Nanoparticles for the Management of Pulse Beetle, Callosobruchus chinensis L. in Stored Chickpea
Authors: Khandaitaray Trinath , Mishra P.R. , Satapathy Satya Narayan , Shankar Tanmoy , Badjena Tribijayi , Tripathy Barsha , Paikaray Subhashree Subhasmita
Published: December 2023

Background: Pulse beetle, Callosobruchus chinensis L. is a primary pest of stored chickpea which causes 50-60 per cent loss in seed weight and 45.5-66.3 per cent loss in protein content of the seeds and injudicious and indiscriminate use of hazardous synthetic chemicals for preventing storage losses in chickpea may lead to human and animal health issues due to residual hazards. Therefore, the biorational management of the pulse beetle in stored chickpea has been undertaken keeping biology in mind will prevent the loss as well as protect human health hazard. Methodos: The experiments on various non-chemical biorational approaches like effect of elevated levels of CO2 and application of nano particles which control the test insect effectively but have less toxicity to non-target organisms and the environment were studied in the Department of Entomology, College of Agriculture, OUAT, Bhubaneswar, Odisha during 2018-2021. Result: The results showed that elevated levels of CO2 at 60 and 80 per cent for 150 and 30 minutes respectively resulted in cent per cent mortality of the bruchids. Among the nano particles, nano silica and nano zinc applied @1000 ppm and 750 ppm realized the highest mortality of the bruchids.
प्रमुख विचार: दक्षिण और दक्षिण पूर्व एशिया आदि में विकलांगता-समावेशी मानवतावादी कार्रवाई और आपातकालीन गतिविधियाँ
Authors: Chand Obindra , Moore Katie , Thompson Stephen
Published: December 2023

विकलांग लोगों को पर्यावरणीय, सामाजिक और संरचनात्मक दिक्कतों और समस्याओं का विभिन्न जटिल संदर्भों और विविध रूपों में सामना करना पड़ता है। मानवीय और अन्य आपातकालीन प्रतिक्रियाओं के दौरान इन बाधाओं के कारण उन्हें अत्यधिक नुकसान भी उठाना पड़ता है तथा उन्हें उपेक्षित और बहिष्कृत भी किया जाता है।1–3 यह स्थिति विशेष रूप से नेपाल और अन्य दक्षिण और दक्षिण पूर्व एशियाई देशों सहित निम्न और मध्यम आय वाले देशों (low- and middle-income countries) में सामने आई है।4 विकलांग लोगों की जरूरतों, सामाजिक सोच और दुर्गम बुनियादी ढाँचे के बारे में सीमित जागरूकता आपातकालीन स्थितियों में उनके सामने आने वाली चुनौतियों में इजाफा कर सकती है। इसके अलावा, आपदा और आपातकालीन योजना विकलांगता को समावेशी बनाने के लिए बहुत कम तैयारी की गई है तथा योजना भी उसके अनुरूप नहीं है।3,5,6 इससे दक्षिण और दक्षिण पूर्व एशिया में मानवीय और सार्वजनिक स्वास्थ्य आपात स्थितियों के संदर्भ में विकलांगता की पड़ताल होती है। इसका फोकस नेपाल पर है लेकिन सिद्धांत सार्वभौमिक रूप से प्रासंगिक हैं और इन्हें किसी भी संदर्भ के लिए अपनाया जा सकता है। यह सरकार, सिविल सोसाइटी (नागरिक समाज) और मानवीय क्षेत्र के हितधारकों के लिए है। इसका उद्देश्य हितधारकों को यह बेहतर ढंग से समझने में सहायता करना है कि कैसे सामाजिक और सांस्कृतिक मानदंडों और प्रथाओं के साथ-साथ संरचनात्मक असमानताएँ आपात स्थिति में विकलांग लोगों के हाशिए पर ले जाने और बहिष्कार को बढ़ा देती हैं। यह संक्षिप्त विवरण विकलांगता-उत्तरदायी मानवीय और आपातकालीन योजना और हस्तक्षेप के लिए अच्छे अभ्यास के उदाहरण प्रस्तुत करता है। इससे विकलांग लोगों के और अधिक समावेशन की वकालत करने का लक्ष्य रखने वाले लोगों के लिए महत्वपूर्ण विचार भी प्राप्त होता है। यह संक्षिप्त विवरण शैक्षिक साहित्य तथा ओपन-सोर्स डेटा के साक्ष्य पर आधारित है। इसे ओबिन्द्र चंद (एच.ई.आर.डी. इंटरनेशनल, एसेक्स युनिवर्सिटी), केटी मूर (एंथ्रोलॉजिका) और स्टीफन थॉम्पसन (इंस्टीट्यूट ऑफ डेवलपमेंट स्टडीज (आई.डी.एस.)) द्वारा तैयार किया गया है तथा यह विवरण तबीथा ह्रीनिक (आई.डी.एस.) द्वारा समर्थित है। इस संक्षिप्त विवरण को कार्यरूप देने की जबावदारी एस.एस.एच.ए.पी. की है।
Transition from classical to entrepreneurial university: alternative vision (on the example of Derzhavin Tambov State University)
Authors:   Derzhavin Tambov State University, Kurin Andrey Yu. , Makarova Lyudmila N. ,   Derzhavin Tambov State University, Gushchina Tatyana I. ,   Derzhavin Tambov State University
Published: December 2023

Universities have always had a special place in society both as education and research centers. However, in the last decade there has been a worldwide trend of universities moving from a research type to an entrepreneurial one. This shift reflects the new challenges and opportunities for educational organizations in the modern world. Considered theoretical and methodological basis of an entrepreneurial university determines its specifics and its difference from a research or classical one, we analyze of the current state of the Derzhavin Tambov State University based on the strategic academic leadership program “Priority-2030”. G.N. Konstantinov and S.R. Filonovich proposed the matrix of entrepreneurial activity of the university – overcoming the limitations in knowledge generation, teaching and putting knowledge into practice and overcoming resource constraints: overcoming the shortage of human resources, overcoming the shortage of financial resources, overcoming the shortage of information resources. Based on the research mentioned above we formulate the tasks to accelerate the transformation of the Derzhavin Tambov State University into an entrepreneurial type organization: attracting leading scientists to the university in accordance with the needs of the university and the region, more targeted support for interdisciplinary research and networking, creating an accelerator for innovative projects, developing the concept of advanced training of scientific and pedagogical workers, diversifying educational programs, developing the innovative and entrepreneurial environment of the university, etc.
Gender features of identification of younger teenagers with characters of online games
Authors:   Central Polyclinic no. 2 of the Ministry of Internal Affairs of Russia, Ichitovkina Elena G. , Zhernov Sergey V. ,   Derzhavin Tambov State University, Majorov Georgy A. ,   State University of Management
Published: December 2023

The development of information technology, technological progress and the processes of globalization set the task of rapid and continuous self-improvement. New trends that have arisen in people’s lives place increased demands on their personal and social identity, communicative qualities and the ability to regulate their own behavior. The massive spread of online games among children and adolescents has turned them into the main form of leisure, the phenomenon of a new, virtual identity of the individual has been formed. At the stage of formation of life values, a child with computer addiction, limiting the circle of communication with virtual games, becomes attached to a non-existent reality, this reality becomes more important than family, school, communication with peers. Often formed Internet addiction leads to the development of destructive and socially dangerous forms of deviant behavior in the future. In the modern world, digital games offer role models whose behavior players can imitate and identify with. We conduct a continuous empirical survey of 170 younger adolescents to identify gender-specific identification of adolescents with online game characters. The gender specificity and risks of the formation of dependent behavior in two groups of adolescents in the form of identification with the characters of online games are shown. It is proposed to use the results of the study when conducting planned psychological preventive examinations of adolescent.
Model for formation of professionally important qualities among cadets in the system of additional education of Moscow school
Authors:   School no. 630 named after double hero  of the Soviet Union G.P. Kravchenko, Meshcherjacov Dmitry V.
Published: December 2023

The purpose of the study is theoretical substantiation and empirical verification of the effectiveness of the process of formation of professionally important qualities among cadets in the system of additional education within the framework of the project “Cadet class in Moscow school”. The task of the study necessitated the development of a model for the formation of professionally important qualities of cadets in the additional education of the Moscow school, to determine the indicators and levels that evaluate the effectiveness of their formation. The study used activity-based, personality-oriented, culturological methodological approaches, united by the general methodological principle of consistency. A model for the formation of professionally important qualities of cadets has been developed, which allows for theoretical and applied research. The pedagogical conditions for the formation of professionally important qualities of cadets that contribute to improving the effectiveness of the system of additional education of the Moscow school are determined. The expected social consequences of the practical use of the research results will be the high readiness of cadets to study at military universities. The originality of the research remains relevant and valuable not only due to the short duration of the project, which led to the fact that such a phenomenon as the formation of professionally important qualities of cadets of the project “Cadet class in Moscow school” has not found proper consideration in psychological and pedagogical research, but also in the fact that the above process is different complexity, has different dynamics of formation, features of its manifestation in students.
Taboo and professional thinking of an educator
Authors:   Penza State University, Gagaev Pavel A. , Gagaev Andrey A. ,   National Research Ogarev Mordovia State University
Published: December 2023

The research examines the issue of taboo in the professional thinking of an educator. The taboos in the educator’s thinking are reasonable. The appeal to the taboo in the history of pedagogy and education is approved. The expediency of attention to taboos is justified by the metaphysical (universal) nature of the student’s psyche. Taboo as an expression of the metaphysical nature of the student’s psyche has a beneficial effect on the interaction of educator and student (laissez-faire pedagogy). The most important taboos in the educator’s thinking are called and deployed from the side of psycho-epistemology: inviolability of the student’s spirituality (ensemble of universal semantics and intentions in the student’s psyche), inviolability of the student’s maternal cultural tradition (picture of the human world as a carrier of a certain language, faith, etc.) and inviolability of the student’s dignity (ideas about oneself as an irreplaceable substance in the universe). Tabooing is considered as a strategy of addressing the educator to the student. The special significance of the appeal to the taboo for the modern Russian school is stated, which, by its general rationalization and pragmatism of the content of teaching, intrudes into the spiritual being of the student and displaces the organic for them (universal).
Value-motivational component of educator’s digital competence
Authors:   Siberian Federal University, Soldatov Dmitry P.
Published: December 2023

Currently, there is an active development of digital technologies that affect all spheres of human life. In addition to the need to train personnel for the digital economy, we are faced with the consequences of the covid-19 coronavirus pandemic. All this has become a reason to believe that one of the most important directions of the development of education in Russia is digitalization. In connection with this trend, new requirements are being put forward for educators of all areas, there is a need for the formation of digital competence. Digital competence goes beyond the simple possession of technical skills and includes a deep understanding and effective use of digital tools in teaching practice. It also implies the ability to adapt to an ever-changing digital environment, critically analyze information, solve problems using digital resources, and communicate effectively in virtual and interactive environments. This study is an attempt to systematize and analyze the role and content of the value-motivational component of educator’s digital competence. We conducted an analysis of current scientific research, identified the key criteria for the presence of this component and emphasized its essential importance in the process of formation and development of digital competence. The conclusions and recommendations obtained may be in demand when developing educational programs, trainings and other educational resources aimed at preparing educators for the successful integration of digital technologies into the educational process.
Analysis of Symmetric and Asymmetric Effects of Exchange Rate Pass-Through in Inflation-Targeting Countries
Authors: Syamad  , Handoyo Rossanto Dwi
Published: December 2023

The main purpose of this study is to analyze the effects of symmetry and asymmetry of the exchange rate pass-through in Middle-Income and High-Income countries that implement inflation-targeting policies. This study uses a sample of Middle-Income Countries (South Africa, Brazil, India, Indonesia, and Mexico) and High-Income Countries (Australia, Japan, Canada, Norway, and Sweden) in the form of time-series 2000:Q1- 2021:Q4 with the method of Autoregressive Distribution Lag (ARDL) and Nonlinear Autoregressive Distributed Lag (NARDL). The results showed that five countries have a significant positive effect on the real exchange rate on inflation in the short-run in the ARDL method. In addition, in the NARDL method, five countries significantly positively affect the depreciation of the real exchange rate on inflation in the short-run. Then, only one country has a significant negative effect between the appreciation of the real exchange rate on inflation in the short-run and eight countries in the long-run. Based on the estimation results, it can be concluded that the average quantity of real exchange rate effect on inflation (exchange rate pass-through) in Middle-Income Countries is greater than in High-Income Countries. Therefore, inflation-targeting policies are more flexible to be applied in high-income countries. In addition to the exchange rate, other variables such as oil prices, money supply, and real GDP also greatly affect inflation and have different effects in each country.