bluuebunny/crossref_metadata_2025 huggingface dataset:
O homem é formador de mundo: mundo como conceito metafísico segundo Martin Heidegger
Authors: Kreibich Susiane
Published: August 2017

O nosso artigo tem como objetivo apresentar a formulação do conceito de mundo no âmbito da obra Os conceitos fundamentais da metafísica: mundo, finitude e solidão, de Martin Heidegger. A partir da pergunta “o que é mundo?”, Heidegger formula o conceito de mundo por consideração comparativa entre as teses “a pedra é sem-mundo”, “o animal é pobre de mundo” e “o homem é formador de mundo”. A tese “a pedra é sem-mundo” discute acerca dos entes materiais, os quais possuem tal constituição que a sua essência é a ausência de acesso ao ente. Já a tese “o animal é pobre de mundo” analisa o modo de ser do animal, cujo acesso ao ente se dá de maneira diversa e com limites estreitos. Por fim, a tese “o homem é formador de mundo” apresenta a caracterização da essência de mundo, sendo este a abertura do ente enquanto tal na totalidade.
The effect of capsicum frutescens-l to transient receptor potential vinaloid-1, toll like receptors (tlr-4) and interleukin 1 beta (il-1β) on periodontitis
Authors: Sunariani Jenny , Mooduto Latief , Yuliati Yuliati
Published: August 2017

Objective: Indonesia has many kinds of useful herbs, which are often used as species such as chili, pepper or cayenne pepper (Capsicum frutescens L). Previous study showed topical capsaicin can be used as a therapy to cure pain due to inflammation. Small concentrations of capsaicin can attenuate cytokines in the inflammatory process. Capsaicin studies in animal model showed activation of the transient receptor potential vanilloid-1. Capsaicin can decrease various cytokines such as IL-6, IL-12, IL-1β, and increase IL-10. Capsaicin is a natural agonist for transient receptor potential vanilloid-1. The aim of this study is to prove the effect of capsaicin on transient receptor potential vanilloid-1 expression and TNF-α and TLR-4 toward pain.Material and Methods: An experimental laboratory research used animal model Wistar male rats (Rattus novegicus) induced with Aggregatibacter actinomycetemcomitans serotype b and green chili extract (Capsicum frutescens L.) with a dose of 0.0912 mg/kg/day was applied to surface of the gingiva on maxillary first molar for 7 days. An immunohistochemical examination was conducted to see the density of transient receptor potential vanilloid-1, and the expression of TLR-4 and IL-1β in the mucosal tissues of the oral cavity.Results: There were significant differences in the applications of Capsicum frutescens L. with increasing of TRPV ligand-1 and IL-1β (p < 0.05), while the TLR-4 (p > 0.05) showed a significant difference to TRPV-1 and IL-1β. There is no significant difference to TLR-4.Conclusion: Capsaicin can increase TRPV-1 and decrease IL-1β but did not affect the TLR-4. Capsaicin can be used to decrease pain and accelerate healing process in periodontitis.
The correlation between denture usage satisfactions on quality life of the elderly
Authors: Akbar Fuad H. , Anwar Ayub I.
Published: August 2017

Objective: To analyze correlation between the denture use satisfactions and quality life of elderly and the relationship between gender and denture use satisfactionMaterial and Methods: This study is an observational analytical study. The sample of study is elderly population aged ≥50 years who live in Luwu Timur, South Sulawesi, the sample was to fill the questioner form based on OHIP-EDENT from WHO. The Chi-square test was used to analyze the relationship between gender and denture use satisfactions.Results: Spearman’s correlation test results for each domain OHIP-EDENT and OHIP-EDENT total showed a significant correlation of (p < 0.05) between denture use satisfaction and functional limitations, physical pain, psychological discomfort, and physical disability domain showed significant. Meanwhile, chi-squared test for denture use satisfactions to gender does not have a significant relationship.Conclusion: The denture use satisfactions has no correlation to quality of life of older adults. The gender dose not influence the satisfactions in denture use.
A Review of Von Hippel-Lindau Syndrome
Authors: Varshney Neha , Kebede Amanuel A. , Owusu-Dapaah Harry , Lather Jason , Kaushik Manu , Bhullar Jasneet S.
Published: August 2017

Von Hippel-Lindau syndrome (VHL) is a familial neoplastic condition seen in approximately 1 in 36,000 live births. It is caused by germline mutations of the tumor suppressor gene VHL, located on the short arm of chromosome 3. While the majority of the affected individuals have a positive family history, up to 20% of cases arise from de novo mutations. VHL syndrome is characterized by the presence of benign and malignant tumors affecting the central nervous system, kidneys, adrenals, pancreas, and reproductive organs. Common manifestations include hemangioblastomas of the brain, spinal cord, and retina; pheochromocytoma and paraganglioma; renal cell carcinoma; pancreatic cysts and neuroendocrine tumors; and endolymphatic sac tumors. Diagnosis of VHL is prompted by clinical suspicion and confirmed by molecular testing. Management of VHL patients is complex and multidisciplinary. Routine genetic testing and surveillance using various diagnostic techniques are used to help monitor disease progression and implement treatment options. Despite recent advances in clinical diagnosis and management, life expectancy for VHL patients remains low at 40–52 years. This article provides an overview of the major clinical, histological, and radiological findings, as well as treatment modalities.
ACCESSIBILITY, ACCOUNTABILITY AND THE IMPACT OF SOCIAL ENTERPRISE
Authors: KARAMOY Herman , PANGEMANAN Sifrid , ILAT Ventje
Published: August 2017

Social Enterprise is the organization that applies business methods and practices to create benefits to the society. This paper finds the problems encountered by Social Enterprise and its benefits to the society, the impact of the Social Enterprise programs and activities, also the influence of the stakeholders to social enterprises. This paper also discusses the Accessibility and Accountability of Social Enterprises. The Netherland Case is used as a basis for the discussion of accountability. Result shows that stakeholders need information concerning the effeciency and effectiveness of Social Enterprises activities, though empirically it is not possible for all stakeholders to have direct access to a Social Enterprise’s complete information. Accountability and Accessibility are empirically influenced by organization Reputation and Legitimacy. It is found that, the better the social or impact value achieved, the stronger the legitimacy and reputation. The more compliance with regulation and guidelines, the less the oversight and scandals, in turn, increases the stakeholders’ trust.
AVRUPA BİRLİĞİ DÖNEM BAŞKANLIĞI SİSTEMİ VE AVRUPA BİRLİĞİ POLİTİKALARINA ETKİSİ
Authors: ULTAN Mehlika Özlem
Published: August 2017

Avrupa Birliği’nde, 6 ayda bir değişen rotasyon sistemiyle gerçekleşen dönem başkanlığı, ülke devlet ve hükümet başkanlarının kendilerini uluslararası alanda gösterebilecekleri bir sistemdir. Dönem başkanlığını yürüten üye ülke, trio olarak adlandırılan üçlü gruplar halinde bir arada çalışmaktadırlar. Trio, uzun vadeli hedefler belirlemekte ve 18 aylık bir süre boyunca ön planda olacak önemli konuları belirleyen ortak bir gündem hazırlamaktadır. Avrupa Birliği’nin başından beri var olan bu sistem, genişleme ve derinleşme süreçleriyle yenilenmiş ve daha verimli hale getirilmeye çalışılmıştır. Bu çalışma kapsamında, özellikle Lizbon Antlaşması’nın yürürlüğe girmesinden sonra dönem başkanlığı yapan ülkelerin politikaları analiz edilecektir. Bu çerçevede trionun ortak bir politika mı yürüttüğü yoksa her dönem başkanı ülkenin kendi önceliklerini mi uygulamaya çalıştığı araştırılacaktır. Sonuç olarak, politik öneme sahip olan bu sistemin, Avrupa Birliği’nde politika yapımına ne derece katkı sağladığı anlaşılmaya çalışılacaktır.
Π SAYISININ RASGELELİĞİNİN SINANMASI
Authors: İNANÇ Şahin , SEZEN H. Kemal
Published: August 2017

Benzetim çalışmalarının bir parçası olarak rasgele sayılar genellikle bilgisayarlar tarafından üretilir. Bu çalışmanın amacını, benzetim çalışmalarında kullanılabilmesi için sözde rasgele üretecinin rasgeleliğinin sınanması ve doğrulanması oluşturmaktadır. İlave olarak bu çalışmada rasgelelik testlerini yapmadan önce ? sayısının elde edilişine değinilmiştir. Bunun için hangi hesaplama yöntemi kullanıldığı, hesaplanmanın matematiksel olarak daha basit bileşenlere ayrılması, bilgisayar programı ile nasıl programlanabileceği ve istenilen basamağa kadar basit bir şekilde nasıl hesaplanabileceğine yer verilmiştir. Bu çalışmada ? sayısının ilk 10000 basamağı elde edilmiş ve beş farklı rasgelelik testi ile rasgeleliğinin sınanması yapılmıştır. Dizi ? sayısının virgülden sonraki basamaklarından oluşturulmuştur. Bu dizinin rasgeleliğinin araştırılması için C# programlama dilinde bir program geliştirilmiştir. Rasgeleliğin sınanması için Ki-kare testi, Kolmogorov- Smirnov testi, Poker testi, Gap (Aralık) testi, Run (koşu) testi uygulanmıştır.
Anthelminthikaresistenz bei Wiederkäuern: Entwicklung, Diagnostik und Maßnahmen
Authors: Pfister Kurt , Knubben-Schweizer Gabriela
Published: August 2017

Anthelminthikaresistenzen von Magen-Darm-Würmern bei kleinen Wiederkäuern, aber auch bei Rindern und Pferden sind inzwischen weit verbreitet. Verantwortlich für die zunehmenden Anthelminthikaresistenzen ist unter anderem ein breiter Einsatz aller auf dem Markt verfügbaren Wirkstoffe. Ein breiter Einsatz führt zu einer Selektion natürlich vorkommender Resistenzgene innerhalb Parasitenpopulationen. Die aktuell praxistauglichste Methode zur Beurteilung der Wirksamkeit eines Anthelminthikums ist der Eizahlreduktionstest. Zur Verlangsamung der Resistenzentwicklung müssen die verfügbaren Wirkstoffe reduziert und selektiv eingesetzt werden. Ein Teil der Herde bleibt bei der selektiven Entwurmung unbehandelt. Es gilt also, die Tiere zu erkennen, die eine Behandlung aus gesundheitlichen oder wirtschaftlichen Gründen benötigen. Die Befunde können an Einzel tieren oder an ausgewählten Tiergruppen erhoben werden. Um zu entscheiden, welche Gruppen von Tieren einer Herde behandelt werden müssen (Targeted Treatment), eignen sich beispielsweise die Unter suchung von Sammelkotproben (Rind und kleine Wiederkäuer), die Messung der Pepsinogenkonzentration im Serum (Rind) oder die Bestimmung von Antikörpern gegen Ostertagia-ostertagi-Antigene in der Tank milch (Rind). Für die Einzeltierbehandlung (Targeted Selective Treatment) können Kriterien wie Eiausscheidung (Rind und kleine Wiederkäuer), Farbe der Konjunktiven als Hinweis für den Befall mit Haemonchus contortus (FAMACHA®, kleine Wiederkäuer), Nährzustand adulter Tiere (kleine Wiederkäuer), Gewichtszunahme bei Jungtieren (Rind und kleine Wiederkäuer) und Kotkonsistenz (kleine Wieder käuer) herangezogen werden. Diese Entscheidungskriterien lassen sich auch kombinieren, was die Aussagekraft steigert. Des Weiteren sollte zu Beginn der Weidesaison regelmäßig eine Wirksamkeitsprüfung der eingesetzten Wirkstoffe erfolgen und während der Weide saison durch Weidemanagement versucht werden, den Parasitendruck gering zu halten. Ziel des selektiven, nachhaltigen Anthelminthikaeinsatzes ist die reduzierte Anwendung von Wirkstoffen bei erhaltener Produktivität und Gesundheit der Tiere und somit eine längere Wirksamkeit der verfügbaren Präparate.
Innovations in Educating and Building the Paediatric Theatre Team. The use of Social Media
Authors: Bird Ruth , Harris Sean
Published: August 2017

This article was migrated. The article was marked as recommended. The use of social media around the world has exploded in recent years, with the number of monthly active users of Twitter estimated to be one quarter billion in 2015 and as such is becoming a useful tool for communication and education.4 It can be a way of asking questions pertinent to medical education, research, clinical practices and guidelines bringing the global medical community together. It enables an immediate exchange of information and ideas around shared areas of interest. Good ideas can be dissipated, allowing amendments of services and quality improvement. Human resource departments and team leaders should be encouraging the use of social media as a productive way of engaging/educating employees and providing positive feedback to teams. Organisations should strive to successfully integrate social media into their internal communications. Twitter feeds provide alternative solutions to tired intranets, message boards and newsletters and keep team members current, up to date and improve team performance.
RECURSOS HUMANOS DE ENFERMAGEM
Authors: Carvalho Amália C. de
Published: August 2017

Trata do problema da escassez de pessoal de enfermagem no País e da precariedade do subsistema formados desse pessoal, em termos numéricos. Encarece a necessidade do aumento amplamente divulgado e discutido, especialmente à luz das metas e recomendações comidas no Plano Decenal de Saúde para as Américas, 1971—1980, resultado da III Reunião Especial dos Ministros de Saúde das Américas.
SUGESTÃO DE UM CRITÉRIO DE VIGILÂNCIA DE ESTADO NUTRICIONAL (C.V.E.N.) PARA PRÊ-ESCOLARES
Authors: Moraes Esther
Published: August 2017

Sugestão de um critério de vigilância de estado nutricional (C. V. E. N.) para pré-escolares O C. V. E. N. consiste no registro das deficiências de crescimento, com base nos conceitos de cronicidade e severidade de WATERLOW & ALLEYNE (1971) e na classificação da altura das crianças, de acordo com a orientação de MARCONDES et al. (1974); põe em evidência a possível influência do tempo e da intensidade de carência alimentar nas deficiências de crescimento apresentadas pelas crianças. Estas deficiências são expressas em números absolutos, ao invés de porcentagens ou índices. A aplicação do Critério de Vigilância de Estado Nutricio-nal mostrou que a sensibilidade deste critério para detectar deficiências de crescimento aproxima-se à sensibilidade da classificação de GOMEZ (1956) — 80% e 84,2%, respectivamente. A equivalência na determinação das deficiências de crescimento entre estes dois critérios é a seguinte: crianças que apresentaram severidade e cronicidade, e que foram classificadas como desnutridas de I e II grau, apresentaram respectivamente, deficiências médias de 0,72 ± 0,57 kg e 6,4 ± 1,38 cm e de 1,40 ± 0,73 kg e 9,6 ± 2,30 cm, significativamente diferentes, ao nível de 0,01%; crianças que apresentaram severidade, apenas, e que foram consideradas como desnutridas de I e II grau apresentaram, respectivamente, deficiências médias de 1,10 ± 0,52 kg e de 2,41 ± 0,42 kg, significativamente diferentes, ao nível de 0,01%.
SUBSIDIOS PARA A CARACTERIZAÇÃO DO ESTUDANTE DE ENFERMAGEM NAS ESCOLAS DO ESTADO DE SÃO PAULO
Authors: Nakamae Djair Daniel
Published: August 2017

Porque parece ser importante manter atualizadas informações quanto a dados demográficos, origem socio-econômica, vida escolar, situação econômica atual, requisitos para o aproveitamento escolar, aspiração e informação sobre a carreira que caracterizam o estudante de enfermagem, e que no campo prático podem oferecer elementos para adequar programas e métodos de ensino, fez-se a pesquisa em 1973, com o objetivo de levantar tais informações. Estudo de tipo descritivo, realizou-se o levantamento dos dados, através de aplicação de questionário com 38 itens em 150 alunos de terceira série das seis escolas de enfermagem existentes no Estado de São Paulo. Alguns resultados são destacados a seguir; 48,4% dos ter-ceiranistas são netos de estrangeiros, predominando grandemente os japoneses; há razoável mobilidade de estudantes dentro do Estado e relativamente pequena entre os mesmos; 43,3% dos estudantes trabalhavam antes de ingressar na Faculdade de Enfermagem; alta incidência de normalistas e de indivíduos sem o curso científico; quase a metade prestou exame vestibular para outro curso; 57,9% dos estudantes trabalham atualmente em atividades remuneradas; destes a maioria o faz por necessidade financeira; metade dos alunos cursam escolas pagas, destes a maioria tem despesas com taxas e anuidade superiores a dois mil cruzeiros; 37,2% tem jornada de trabalho diário em torno de 8 ou mais horas; 62,9% estudam menos de dez horas/semana fora do período de aula; 64,7% alegou como motivo principal de sua escolha pelo curso a inclinação pela profissão e predominam os que estão satisfeitos com sua escolha; metade classifica como boas as possibilidades de trabalho existentes; 72% dos estudantes pretendem exercer a profissão em Serviço hospitalar no ano seguinte a formatura. Algumas conclusões sobre as características principais do estudante põem as enfermeiras educadoras diante de um panorama não muito otimista. Por um lado, a metade dos estudantes não teve preparação escolar adequada ao currículo das escolas de enfermagem e, por outro lado, uma mesma proporção trabalha para se manter no curso. O perfil do estudante traçado pela pesquisa, evidencia a emergência de problemas correlacionados, interferindo diretamente em seu rendimento escolar. Procurar resolvê-los dentro do âmbito próprio do ensino de enfermagem, afigura-se como a mais realista nas condições atuais. O caminho parece
PROGRAMA DE ENFERMAGEM DE SAÚDE PÚBLICA DA ESCOLA DE ENFERMAGEM DA USP
Authors: Nogueira Maria Jacyra de Campos , Ramos Netto Malvina de Oliveira , Guedes Eloisa Aparecida , Egry Emiko Yoshikawa , Fonseca Rosa M. Godoy Serpa da
Published: August 2017

Os autores descrevem os principios, o conteúdo e a metodologia utilizada para o ensino de enfermagem de saúde pública na Escola de Enfermagem da Universidade de São Paulo, anexando no final, esquemas dos programas.
SISTEMA DE AVALIAÇÃO DE ALUNOS EM PRÁTICA DE CAMPO EM ADMINISTRAÇÃO APLICADA À ENFERMAGEM
Authors: Kurcgant Paulina
Published: August 2017

O autor procurou analisar o sistema de avaliação aplicado aos estudantes do curso de graduação em Enfermagem na disciplina Administração aplicada à Enfermagem da Escola de Enfermagem da Universidade de São Paulo. O objetivo dessa avaliação é obter um perfil da atuação dos estudantes na prática de campo comparando-o com o padrão de desempenho determinado pela disciplina.
IMMUNOMODULATING EFFECTS OF THE PURIFIED HEV B 13 FRACTION ON SEPTIC RATS
Authors: ALVES Maxley Martins , ARAÚJO Lilhian Alves de , MRUÉ Fátima , GOMES Clayson Moura , OLIVEIRA Milton Adriano Pelli de , NEVES Roberpaulo Anacleto , SILVA-JÚNIOR Nelson Jorge da , MELO-REIS Paulo Roberto de
Published: August 2017

ABSTRACT Background: Sepsis is a potentially life-threatening complication of an infection that occurs when chemicals released into the bloodstream to fight the infection trigger inflammatory responses throughout the body, especially in the acute phase of the disease, producing excessive pro-inflammatory cytokines, leading to multiple organ injury and death. The Hev b 13 fraction has demonstrated biological activity capable of inducing IL-10 production and shrinking inflammatory disease lesions. Aim: To investigate the immunomodulating effects of the Hev b 13 fraction on septic rats. Methods: Acinetobacter baumannii was injected into the peritoneal cavity of the animals after sustaining a lesion in the pancreas, with the stomach as an entry point. After 10 h of infection, they were euthanized for blood and lung collection, followed by total and differential leukocyte count, determination of cytokine level and histopathological analysis. Results: Administering a single dose of the Hev b 13 fraction 2 h after sepsis induction significantly decreased total leukocyte count. Higher IL-10 and IL-4 and lower IL-6 production shrank the lung tissue lesions compared to the control groups. Conclusion: The Hev b 13 fraction exhibits an anti-inflammatory tendency, with potential for sepsis treatment.
PROGNOSTIC FACTORS FOR LEFT COLECTOMY FOR COLON CANCER: A TEN YEARS EXPERIENCE OF A SINGLE UNIVERSITY INSTITUTION
Authors: NAHAS Sergio Carlos , NAHAS Caio Sergio , BUSTAMANTE-LOPEZ Leonardo Alfonso , PINTO Rodrigo Ambar , MARQUES Carlos Frederico Sparapan , CAMPOS Fabio Guilherme , CECCONELLO Ivan
Published: August 2017

ABSTRACT Background: Colorectal cancer is the third most common cancer in the world. In Brazil, it is the leading cause of cancer in the gastrointestinal tract. Aim: To evaluate the preoperative, perioperative, and postoperative risk factors for recurrence and overall survival of patients with left colon cancer operated during a ten-year period. Methods: Patients with left colon cancer surgically treated underwent clinical preoperative workout and cancer staging. The following factors were studied: gender, age, tumor location, T stage, lymph node yield, N stage, M stage, histological type, and tumor differentiation. It was analyzed the influence in five-year overall survival. Results: A total of 173 patients underwent left colectomy for colon cancer. There was a slight predominance of male gender with 50.9%. The mean age was 60.8 years old. Fifteen (8.7%) tumors were located at splenic flexure, 126 (72.8%) at sigmoid colon, and 32 (18.5%) at descending colon. The median length of hospital stay was seven days. Mean survival was 47.5 months. At 60 months seven patients (4%) lost follow-up, 38 patients (21.9%) deceased and 135 patients (78%) were alive. Overall survival time was 48 months. Conclusion: Advanced stages (T3-T4, N+ and M+) were the only factors associated with poor long term survival in left colon cancer.
STEM CELLS HEMATOPOIETIC NICHES AND INFLAMMATORY RESPONSE TO DIFFERENT SYNTHETIC PROSTHESIS IMPLANTED IN RAT WITH INCISIONAL HERNIAS
Authors: BARBIERI Renato Lamounier , PARREIRA Suely de Fátima , STUDART Sarah do Valle , DA-SILVA Aline Riquena , DUARTE Ivone da Silva , LEME Pedro Luiz Squilacci
Published: August 2017

ABSTRACT Background: Extramedullary hematopoiesis depends on complex pathophysiological mechanisms linked to hematopoietic stem cells and the proteins considered mediators of the inflammation. The identification of hematopoietic cells outside bone marrow in the adult is an occurrence that can occasionally follows the inflammatory response, was considered a secondary occurrence, but current biomolecular studies have changed that concept. Aim: Describe the presence of clusters of precursor cells of platelets (megakaryocytes), and cells of the inflammatory response in the abdominal wall and spleen of rats with experimentally induced incisional hernias and repaired with different synthetic prostheses. Methods: Twenty-five rats with incisional hernias previously performed, were divided into groups of five animals each: Group 1, repair of the hernia defect without prosthetic implant; Group 2, repair with polypropylene prosthesis; Group 3, repair using polypropylene with low weight; Group 4, the use of polypropylene and polyglecaprone prosthesis; Group 5, of polypropylene and polyglactin prosthesis. All prostheses were cut in rhombus format with area 2,625 cm². The animals were reoperated after 10 days, the abdominal walls were removed with the viscera attached to them and the material was processed for histological study. Results: Megakaryocyte niches in the abdominal wall and spleen, occasionally removed together with the adhesions produced in animals with implantation of prostheses and significant inflammatory reaction. Conclusion: The intense inflammatory reaction due to the prostheses with polypropylene in their composition was disproportionate to the expected response, indicating that further studies should be accomplished including immunophenotyping evaluation and specific panels of monoclonal antibodies to better understand the findings.
BILIARY COMPLICATIONS AFTER LIVER TRANSPLANTATION
Authors: COELHO Júlio Cezar Uili , LEITE Lucas de Oliveira , MOLENA Antonio , FREITAS Alexandre Coutinho Teixeira de , MATIAS Jorge Eduardo Fouto
Published: August 2017

ABSTRACT Background: Biliary reconstitution has been considered the Achilles’s heel of liver transplantations due to its high rate of postoperative complications. Aim: To evaluate the risk factors for occurrence of biliary strictures and leakages, and the most efficient methods for their treatment. Method: Of 310 patients who underwent liver transplantation between 2001 and 2015, 182 medical records were retrospectively analyzed. Evaluated factors included demographic profile, type of transplantation and biliary reconstitution, presence of vascular and biliary complications, their treatment and results. Results: 153 (84.07%) deceased donor and 29 (15.93%) living donor transplantations were performed. Biliary complications occurred in 49 patients (26.92%): 28 strictures (15.38%), 14 leakages (7.7%) and seven leakages followed by strictures (3.85%). Hepatic artery thrombosis was present in 10 patients with biliary complications (20.4%; p=0,003). Percutaneous and endoscopic interventional procedures (including balloon dilation and stent insertion) were the treatment of choice for biliary complications. In case of radiological or endoscopic treatment failure, surgical intervention was performed (biliodigestive derivation or retransplantation (32.65%). Complications occurred in 25% of patients treated with endoscopic or percutaneous procedures and in 42.86% of patients reoperated. Success was achieved in 45% of patients who underwent endoscopic or percutaneous procedures and in 61.9% of those who underwent surgery. Conclusion: Biliary complications are frequent events after liver transplantation. They often require new interventions: endoscopic and percutaneous procedures at first and surgical treatment when needed. Hepatic artery thrombosis increases the number of biliary complications.
THE VULKAN TECHNIQUE: A NOVEL OSTOMY-CLOSURE TECHNIQUE THAT REDUCES COMPLICATIONS AND OPERATIVE TIMES
Authors: KRENZIEN Felix , BENZING Christian , HARDERS Fabian , JUNGHANS Tido , RASIM Gyurdhan , BOTHE Claudia , PRATSCHKE Johann , ZORRON Ricardo
Published: August 2017

ABSTRACT Background: Ostomy reversals remain at high risk for surgical complications. Indeed, surgical-side infections due to bacterial contamination of the stoma lead to revision surgery and prolonged hospital stay. Aim: To describe the novel vulkan technique of ostomy reversal that aims to reduce operative times, surgical complications, and readmission rates. Methods: Ostomy closure was performed using the vulkan technique in all patients. This technique consists of external intestinal closure, circular skin incision and adhesiolysis, re-anastomosis, and closure of the subcutaneous tissue in three layers, while leaving a small secondary wound through which exudative fluid can be drained. The medical records of enterostomy patients were retrospectively reviewed from our hospital database. Results: The vulkan technique was successfully performed in 35 patients mainly by resident surgeons with <5 years of experience (n=22; 62.8%). The ileostomy and colostomy closure times were 53 min (interquartile range [IQR], 41-68 min; n=22) and 136 min (IQR: 88-188 min; n=13; p<0.001), respectively. The median hospital stay was seven days (IQR: 5−14.5 days); the length of hospital stay did not differ between ileostomy and colostomy groups. Major surgical complications occurred only in patients who underwent colostomy closure following the Hartmann procedure (n=2); grade≥IIIb according Clavien-Dindo classification. Conclusion: The vulkan technique was successfully applied in all patients with very low rates of surgical-site infections. Off note, residents with limited surgical experience mainly performed the procedure while operating time was less than one hour.
GASTRIC NEUROENDOCRINE TUMOR: REVIEW AND UPDATE
Authors: DIAS Andre Roncon , AZEVEDO Beatriz Camargo , ALBAN Luciana Bastos Valente , YAGI Osmar Kenji , RAMOS Marcus Fernando Kodama Pertille , JACOB Carlos Eduardo , BARCHI Leandro Cardoso , CECCONELLO Ivan , RIBEIRO-JR Ulysses , ZILBERSTEIN Bruno
Published: August 2017

ABSTRACT Introduction: The frequency of gastric neuroendocrine tumors is increasing. Reasons are the popularization of endoscopy and its technical refinements. Despite this, they are still poorly understood and have complex management. Aim: Update the knowledge on gastric neuroendocrine tumor and expose the future perspectives on the diagnosis and treatment of this disease. Method: Literature review using the following databases: Medline/PubMed, Cochrane Library and SciELO. Search terms were: gastric carcinoid, gastric neuroendocrine tumor, treatment. From the selected articles, 38 were included in this review. Results: Gastric neuroendocrine tumors are classified in four clinical types. Correct identification of the clinical type and histological grade is fundamental, since treatment varies accordingly and defines survival. Conclusion: Gastric neuroendocrine tumors comprise different subtypes with distinct management and prognosis. Correct identification allows for a tailored therapy. Further studies will clarify the diseases biology and improve its treatment.
RANK/RANKL/OPG Expression in Rapid Maxillary Expansion
Authors: Arnez Maya Fernanda Manfrin , Ribeiro Larissa Soares Nogueira , Barretto Gabriel Dessotti , Monteiro Patrícia Maria , Ervolino Edilson , Stuani Maria Bernadete Sasso
Published: August 2017

Abstract The aim of this study was to evaluate osteoclastogenesis signaling in midpalatal suture after rapid maxillary expansion (RME) in rats. Thirty male Wistar rats were randomly assigned to two groups with 15 animals each: control (C) and RME group. RME was performed by inserting a 1.5-mm-thick circular metal ring between the maxillary incisors. The animals were euthanized at 3, 7 and 10 days after RME. qRT-PCR was used to evaluate expression of Tnfsf11 (RANKL), Tnfrsf11a (RANK) and Tnfrsf11b (OPG). Data were submitted to statistical analysis using two-way ANOVA followed by Tukey test (a=0.05). There was an upregulation of RANK and RANKL genes at 7 and 10 days and an upregulation of the OPG gene at 3 and 7 days of healing. Interestingly, an increased in expression of all genes was observed over time in both RME and C groups. The RANKL/OPG ratio showed an increased signaling favoring bone resorption on RME compared to C at 3 and 7 days. Signaling against bone resorption was observed, as well as an upregulation of OPG gene expression in RME group, compared to C group at 10 days. The results of this study concluded that the RANK, RANK-L and OPG system participates in bone remodeling after RME.
The In Situ Effect of Titanium Tetrafluoride Gel on Erosion/Abrasion Progression in Human Dentin
Authors: Mantilla Taís Fonseca , Turssi Cecilia Pedroso , Ramos-Oliveira Thayanne Monteiro , Silva Camila Vieira da , Suzuki Luis Cláudio , Freitas Patricia Moreira de
Published: August 2017

Abstract Erosion incidence is increasing and its control is still a challenge in clinical practice. This study evaluated 4% TiF4-gel effects on eroded human dentin subjected to in situ erosive/abrasive episodes. Seventy-two previously eroded dentin slabs (0.05 M citric acid, pH 2.3, 20 min) were allocated to 6 groups (n=12) according to the treatment to be performed during the in situ phase and number of erosive/abrasive cycles, as follows: 4% TiF4-gel applied once (TiF41), twice (TiF42) or three times (TiF43) followed by 1, 2 and 3 erosive/abrasive cycles, respectively. Gel was applied before the beginning of the next cycle. Control groups were subjected to 1 (C1), 2 (C2) and 3 (C3) erosive/abrasive cycles only. A seventh group (n=12) comprised in vitro uneroded samples (UN) subjected to 3 erosive/abrasive cycles. Each cycle corresponded to 2 days of erosive (citric acid 0.5%, pH 2.6, 6x/day) and abrasive (electric toothbrush, 10 s/sample, 1 x/day) challenges. Samples were evaluated under profilometry and environmental scanning electron microscopy (ESEM). Atomic force microscopy images (AFM) were also made (n=3). Repeated measures 2-way ANOVA and Tukey test (p<0.001) showed that TiF42, which did not differ from TiF41 and TiF43, revealed a significant reduction in surface loss compared to all control groups. TiF41 and TiF43 showed no significant difference from C1, but both groups demonstrated significantly smaller surface loss than C2 and C3. ESEM and AFM micrographs suggested alterations on treated surfaces compared to samples from control groups, showing reduced diameters of dentinal tubules lumens. Therefore, TiF4 was able to reduce the progression of erosive/abrasive lesions.
Demographic and Clinical Profile of Oral Squamous Cell Carcinoma from a Service-Based Population
Authors: Alves Alessandro Menna , Correa Marcos Britto , Silva Karine Duarte da , Araújo Lenita Maria Aver de , Vasconcelos Ana Carolina Uchoa , Gomes Ana Paula Neutzling , Etges Adriana , Tarquinio Sandra Beatriz Chaves
Published: August 2017

Abstract The aim of this study was to evaluate the demographic and clinical profile of the oral squamous cells carcinoma (OSCC) cases registered in a center of oral diagnosis in southern Brazil. Eight hundred and six individuals with OSCC from 1959 to 2012 were included in this study. The variables recorded were: sex, age, occupation according to workplace, alcohol and tobacco consumption, skin color, tumor location, histological type, clinical appearance, size, evolution time, presence of pain and lymph node metastasis. Descriptive analysis was performed and the associations between variables were assessed using the chi-square and Fisher’s exact test, with a confidence level of 5%. OSSC was more common in males (76.6%) aged between 51 to 70 years (53.9%). The most frequent sites were lower lip vermilion (23.3%), tongue (20.2%) and gingiva/alveolar ridge (18.1%). There was a strong association between outdoor occupation and white skin color with lip squamous cell carcinoma (LSCC). OSCC intraoral lesions were commonly more painful, larger than 2 cm and presented lymphatic metastasis. In conclusion, most of the results confirm the data from literature about sex, age, tumor location and occupation. Moreover, the positive correlations between LSCC and occupation, between LSCC and white skin color, and between bigger lesions and presence of pain/cervical metastasis also corroborate the literature data.
Surgeons’ Performance Determining the Amount of Graft Material for Sinus Floor Augmentation Using Tomography
Authors: Cruz Adriana Dibo , Peixoto Guilherme Alvares , Aguiar Marcelo Freitas , Camargo Gabriela Alessandra Cruz Galhardo , Homs Nicolas
Published: August 2017

Abstract This study aimed to assess the performance of surgeons in determining the amount of graft material required for maxillary sinus floor augmentation in a preoperative analysis using cone-beam computed tomography images. A convenience sample of 10 retrospective CBCT exams (i-CAT®) was selected. Scans of the posterior maxilla area with an absence of at least one tooth and residual alveolar bone with an up to 5 mm height were used. Templates (n=20) contained images of representative cross-sections in multiplanar view. Ten expert surgeons voluntarily participated as appraisers of the templates for grafting surgical planning of a 10 mm long implant. Appraisers could choose a better amount of graft material using scores: 0) when considered grafting unnecessary, 1) for 0.25 g in graft material, 2) for 0.50 g, 3) for 1.00 g and 4) for 1.50 g or more. Reliability of the response pattern was analyzed using Cronbach’s a. Wilcoxon and Mann-Whitney tests were performed to compare scores. Regression analysis was performed to evaluate whether the volume of sinuses (mm3) influenced the choose of scores. In the reliability analysis, all values were low and the score distribution was independent of the volume of the maxillary sinuses (p>0.05), which did not influence choosing the amount of graft material. Surgeons were unreliable to determine the best amount of graft material for the maxillary sinus floor augmentation using only CBCT images. Surgeons require auxiliary diagnostic tools to measure the volume associated to CBCT exams in order to perform better.
Repair of Bone Defects with Chitosan-Collagen Biomembrane and Scaffold Containing Calcium Aluminate Cement
Authors: Moraes Paola Castro de , Marques Isabela Cristina de Souza , Basso Fernanda Gonçalves , Rossetto Hebert Luis , Pires-de-Souza Fernanda de Carvalho Panzeri , Costa Carlos Alberto de Souza , Garcia Lucas da Fonseca Roberti
Published: August 2017

Abstract Innovative biomaterials can provide a promising new direction for the treatment of bone defects, stimulating a proper repair process, with no damage to adjacent tissues. The purpose of this in vivo study was to evaluate the biocompatibility and the osteoinductive capacity of chitosan-collagen biomembrane and scaffold containing calcium aluminate cement. Eighteen New Zealand white rabbits (Oryctolagus cuniculus) were distributed according to the experimental times of analysis (7, 15 and 30 days). Four bone defects were created in the rabbits calvaria, which were individually filled with the biomembrane, scaffold, blood clot (negative control) and autologous bone (positive control). Histopathological analysis was performed using optical microscope at 32´, 64´, 125´ and 320´ magnifications. Cell response to inflammation and new bone tissue formation was quantified using a score system. The biomembrane group presented greater inflammatory response at 15 days, with significant difference to autologous bone group (p<0.05). There was no statistically significant difference for foreign body type reaction among groups (p>0.05). Concerning new bone formation, linear closure of the defect area was observed more evidently in the group with autologous bone. The scaffold group presented similar results compared with the autologous bone group at 30 days (p>0.05). Both tested biomaterials presented similar biocompatibility compared with the control groups. In addition, the biomembrane and scaffold presented similar osteoinductive capacity, stimulating bone repair process in the course of the experimental time intervals.
An Evaluation of the Light Output from 22 Contemporary Light Curing Units
Authors: Soares Carlos José , Rodrigues Monise de Paula , Oliveira Laís Rani Sales , Braga Stella Sueli Lourenço , Barcelos Luciana Mendes , Silva Gisele Rodrigues da , Giannini Marcelo , Price Richard Bengt
Published: August 2017

Abstract This study measured the radiant power (mW), irradiance (mW/cm2) and emission spectra (mW/cm2/nm) of 22 new, or almost new, light curing units (LCUs): - Alt Lux II, BioLux Standard, Bluephase G2, Curing Light XL 3000, Demetron LC, DX Turbo LED 1200, EC450, EC500, Emitter C, Emitter D, KON-LUX, LED 3M ESPE, Led Lux II, Optilight Color, Optilight Max, Optilux 501, Poly Wireless, Radii cal, Radii plus, TL-01, VALO Cordless. These LCUs were either monowave or multiple peak light emitting diode (LED) units or quartz-tungsten-halogen LCUs used in anterior and posterior teeth. The radiant power emitted by the LCUs was measured by a laboratory grade laser power meter. The tip area (cm²) of the LCUs was measured and used to calculate the irradiance from the measured radiant power source. The MARC-Patient Simulator (MARC-PS) with a laboratory grade spectrometer (USB4000, Ocean Optics) was used to measure the irradiance and emission spectrum from each LCU three times at the sensor located on the facial of the maxillary central incisors and then separately at the occlusal of a maxillary second molar. The minimum acceptable irradiance level was set as 500 mW/cm2. Irradiance data was analyzed using two-way ANOVA and the radiant power data was analyzed by one-way ANOVA followed by Tukey test (a=0.05). In general, the irradiance was reduced at the molar tooth for most LCUs. Only the Valo, Bluephase G2 and Radii Plus delivered an irradiance similar to the anterior and posterior sensors greater than 500 mW/cm2. KON-LUX, Altlux II, Biolux Standard, TL-01, Optilux 501, DX Turbo LED 1200 LCUs delivered lower irradiance values than the recommended one used in molar region, KON-LUX and Altlux II LCUs used at the maxillary incisors. Bluephase G2 and Optilight Max delivered the highest radiant power and KON-LUX, Altlux II and Biolux Standard delivered the lowest power. The emission spectrum from the various monowave LED LCUs varied greatly. The multi-peak LCUs delivered similar emission spectra to both sensors.
Drying on the germination and vigor of Crataeva tapia L. seeds
Authors: Alves Edna Ursulino , Santos-Moura Sueli da Silva , Moura Mácio Farias de , Silva Rosemere dos Santos , Galindo Evio Alves
Published: August 2017

ABSTRACT: Crataeva tapia L. is a fruit native to the Brazilian savanna, the Caatinga, and is used in the production of soft drinks and other beverages. Given the importance of this species and the lack of knowledge about its seeds, this research aimed to evaluate the physiological quality of C. tapia L. seeds subjected to different environments and drying periods. Seeds were dried for the following time periods: 0 (no drying), 24, 48, 72, 96, and 120 hours, in the laboratory environment (25°C and 90% RH) and in a greenhouse (30°C and 80% RH). After the drying period, seeds from each of the treatments were used for determining the water content, germination, and vigor (using tests for emergence, first count of germination and emergence, rate of germination and emergence, length, and seedling dry weight). The experimental design was completely randomized and a factorial 2×6 scheme (local environment × drying periods) was used with four replicate sets of seeds. The data were subjected to analysis of variance and polynomial regression using quadratic models. The germination and seed vigor reduced as the drying periods increased. For optimum results, the seeds of C. tapia L. must be dried in the laboratory for a period of 48 hours. In addition, their desiccation resistance was classified as intermediate.
Clinical simulation with dramatization: gains perceived by students and health professionals
Authors: Negri Elaine Cristina , Mazzo Alessandra , Martins José Carlos Amado , Pereira Junior Gerson Alves , Almeida Rodrigo Guimarães dos Santos , Pedersoli César Eduardo
Published: August 2017

ABSTRACT Objective: to identify in the literature the gains health students and professionals perceive when using clinical simulation with dramatization resources. Method: integrative literature review, using the method proposed by the Joanna Briggs Institute (JBI). A search was undertaken in the following databases: Latin American and Caribbean Health Sciences Literature, Web of Science, National Library of Medicine, Cumulative Index to Nursing and Allied Health Literature, The Cochrane Library, Scopus, Scientific Electronic Library Online. Results: 53 studies were analyzed, which complied with the established inclusion criteria. Among the different gains obtained, satisfaction, self-confidence, knowledge, empathy, realism, reduced level of anxiety, comfort, communication, motivation, capacity for reflection and critical thinking and teamwork stand out. Conclusion: the evidence demonstrates the great possibilities to use dramatization in the context of clinical simulation, with gains in the different health areas, as well as interprofessional gains.
Escalado: Arquímedes y un divisor de voltajes
Authors: Wörner C. H.
Published: August 2017

Se aplica la técnica de escalonamiento en dos cuestiones, uno de ellas, una demostración geométrica de Arquímedes y el otro, un circuito atenuador. El contraste de las cuestiones abordadas ambos ejemplos, ilustra la unificación de técnicas en ambos casos.
Elaboração e caracterização de doce cremoso de caqui com adição de sementes da araucária
Authors: Bolzan Aline Balbinotti , Pereira Edimir Andrade
Published: August 2017

Resumo A inovação é um dos pilares para o alcance do desenvolvimento sustentável e, para a inserção de um novo produto alimentício no mercado, abordagens que englobem pesquisas em ciência e tecnologia se fazem necessárias. Visando propor uma alternativa para o uso do pinhão e o aproveitamento de frutos de clima temperado, cultivados no Estado do Paraná, foi elaborado um doce cremoso de caqui, substituindo-se parcialmente a polpa por diferentes concentrações de pinhão nas formulações (0, 5 e 10%). Foram realizadas análises de sólidos solúveis, atividade de água, pH, acidez total titulável, teor de umidade, cinzas, cor e textura, além da caracterização microbiológica dos produtos. Atendendo aos padrões de identidade e qualidade quanto às características físicas, químicas e microbiológicas, a inserção de sementes de pinhão e a consequente redução no teor de polpa promoveram, do ponto de vista tecnológico, o desenvolvimento adequado deste produto inovador. Os valores da atividade de água, a concentração de açúcares e a baixa acidez observados no produto tornaram o ambiente desfavorável ao desenvolvimento de micro-organismos, condições estas associadas às boas práticas de fabricação. A alteração na formulação padrão influenciou na análise instrumental do perfil de textura, devido à presença de amido da semente de pinhão. Os parâmetros de cor apresentaram resultados de baixa luminosidade, o que reporta a produtos pouco translúcidos, o que é característico de alimentos de alto teor de açúcares, concentrados por evaporação. No espaço de cor notou-se a expressão da cromaticidade a* e b*, que apontam para a predominância das cores amarelo e vermelho, característicos do fruto de origem. As investigações abordadas revelam a aplicabilidade tecnológica do pinhão, contribuindo para a agregação de valor através da diversificação de produtos e mostrando-se como uma alternativa para geração de recursos financeiros para pequenos produtores rurais através do extrativismo, garantindo a conservação de espécies da Floresta com Araucária.
Cisalhamento na Linha de Cola de Eucalyptus sp. Colado com Diferentes Adesivos e Diferentes Gramaturas
Authors: Bianche Juliana Jerásio , Teixeira Ana Paula Mendes , Ladeira João Paulo Silva , Carneiro Angélica de Cássia Oliveira , Castro Renato Vinícius Oliveira , Della Lucia Ricardo Marius
Published: August 2017

RESUMO O objetivo deste trabalho foi avaliar a resistência ao cisalhamento na linha de cola de juntas de Eucalyptus sp. coladas com diferentes adesivos e diferentes gramaturas. Para a colagem das juntas foi utilizada a madeira de Eucalyptus sp., dois adesivos de cura a quente (fenol-formaldeído e melamina-formaldeído), quatro adesivos de cura a frio [resorcinol-formaldeído, silicato de sódio, PVA (acetato de polivinila) e poliuretano à base de mamona], empregando-se gramaturas de 150 g, 200 g e 250 g/m2 em face dupla. Foram determinados aresistência ao cisalhamento e à falha na madeira, e cisalhamento em condição úmida. Os resultados obtidos indicaram que os adesivos de mamona e resorcinol apresentaram maior resistência ao cisalhamento na linha de cola na condição seca. Os adesivos de mamona e fenol-formaldeído apresentaram maior percentual de falha na madeira na condição seca.
Similaridade entre Adultos e Regenerantes do Componente Arbóreo em Floresta com Araucária
Authors: Aguiar Manoela Drews de , Silva Ana Carolina da , Higuchi Pedro , Negrini Marcelo , Schollemberg André Luis
Published: August 2017

RESUMO O estudo objetivou inventariar o componente arbóreo regenerante em uma floresta no Planalto Sul de Santa Catarina e compará-lo ao componente adulto da mesma área. Foram alocadas 25 parcelas, onde os regenerantes e adultos foram identificados e quantificados. Foi calculado o Índice de Regeneração Natural Total (RNT) de cada espécie. Para verificar a similaridade entre os componentes, foi utilizada a Análise de Similaridade e o índice de Jaccard. Foram amostrados 503 regenerantes, pertencentes a 58 espécies e 29 famílias. Myrtaceae foi a família de maior riqueza (13). Leandra regnelli (Triana) Cogn., Myrcia splendens (Sw.) DC. e Miconia cinerascens Miq. apresentaram os maiores valores de RNT. Houve elevada dissimilaridade entre regenerantes e adultos, sendo que 37,5% das espécies do componente adulto não tiveram representantes na regeneração natural. Conclui-se que existe uma baixa capacidade regenerativa da maior parte das espécies, o que pode estar associado à presença de gado na área.