bluuebunny/crossref_metadata_2025 huggingface dataset:
Ring Finger Protein 141 (RNF141) Mediates Resistance to Sorafenib in Hepatocellular Carcinoma and Its Mechanisms
Authors: Chen Sheng-Xiong , Xie Xiao-Li , Liu Ting , Jin Xiao-Xu , Wang Jun , Jiang Huiqing
Published: April 2024

OBJECTIVE: This study aims to investigate the expression of ring finger protein 141 (RNF141) in hepatocellular carcinoma, its role in sorafenib resistance, and its possible mechanism.
MATERIALS AND METHODS: The expression of RNF141 in the cancer and corresponding para-cancerous liver tissues of patients with hepatocellular carcinoma was detected using Immunohistochemistry (IHC) staining and Western blot. The liver cancer cell line (SMMC7721) and the sorafenib-resistant liver cancer cell line (SMMC7721-S) were transfected with lentivirus to overexpress or silence RNF141, and the IC50 of sorafenib was then measured. Flow cytometry and TUNEL staining were used to detect changes in cell apoptosis before and after overexpression and silencing of RNF141. The levels of the proliferation marker protein, proliferating cell nuclear antigen (PCNA), and the apoptosis marker protein, Cleaved PARP, were detected using Western blot. Additionally, a tumor xenograft model was constructed by subcutaneously injecting RNF141-knockdown SMMC7721 and SMMC7721-S stable transfected strains into nude mice. The study observed and recorded the shape, size, and weight of tumors in each group. Hematoxylin and Eosin (HE) staining and immunohistochemistry (IHC) staining of PCNA were used to verify the effect of RNF141 on the efficacy of sorafenib in vivo. Finally, digital gene expression profiling (DGE) was used to further screen the signaling pathways involved in RNF141-mediated HCC resistance to sorafenib.
RESULTS: The study found that the expression of RNF141 was significantly higher in hepatocellular carcinoma tissues compared to corresponding paracancerous tissues (P<0.01), as shown by IHC staining results and Western blot analysis. Hepatocellular carcinoma cell lines that overexpress and silence RNF141, as well as sorafenib-resistant hepatocellular carcinoma cell lines, were successfully constructed. Overexpression of RNF141 resulted in an increase in the IC50 value of sorafenib in hepatocellular carcinoma cells, as well as the ability to resist sorafenib-induced proliferation inhibition and apoptosis. Conversely, silencing RNF141 resulted in a decrease in the IC50 value of sorafenib, and further enhanced sorafenib-induced proliferation inhibition and apoptosis. The digital gene expression profiling results were analysed using the Kyoto Encyclopedia of Genes and Genomes (KEGG) signalling pathway enrichment analysis, which revealed a significant enrichment of the proteasome signalling pathway.
CONCLUSION: RNF141 may contribute to sorafenib resistance in hepatocellular carcinoma through the proteasome signaling pathway.
Exploration of the Big Five: Dimensionality Reduction and Clustering Techniques
Authors: Gioia Flavio
Published: April 2024

This study presents a comprehensive analysis of the BFI dataset using the 'psych' package in R. Through principal component analysis and descriptive statistical techniques such as PCA, histograms and Classification. We explored the dimensions of personality based on 25 evaluative items from the International Personality Item Pool. Columns A-E highlight the behavioral traits of agreeableness, conscientiousness, extraversion, neuroticism, and openness, measured on a 6-point response scale. The results provide significant insights into the correlations among different traits and offer a richer understanding of human personality dynamics.
Cost-utility analysis of risk-based stratified primary care for common musculoskeletal pain presentations: a cluster-randomised, controlled trial
Authors: Kigozi Jesse , Hill Jonathan C , Bromley Kieran , Lewis Martyn , Wathall Simon , Chudyk Adrian , Dunn Kate M , Foster Nadine E , Jowett Sue
Published: April 2024

Background
Risk-based stratified care (SC) has demonstrated cost-effectiveness versus usual primary care for non-specific low back pain. The STarT MSK trial investigated the cost-effectiveness of risk-based stratified care versus non-stratified usual primary care for patients with the five most common musculoskeletal pain presentations.
Methods
A cost-utility analysis was undertaken over 6-months. The base-case analysis estimated the incremental costs per additional quality-adjusted life year (QALY), using the EQ-5D-5L to generate QALYs, for the overall trial population and for each risk subgroup (low, medium, high risk) for persistent disabling pain. The base-case analysis used the intention-to-treat principle and was performed from an NHS and personal social services (PSS) perspective. Uncertainty was explored with cost-effectiveness acceptability curves. Sensitivity analyses included a healthcare and societal perspective, complete-case, and risk subgroup analyses.
Results
Risk-based stratified primary care showed similar costs to usual primary care, with a small QALY gain of 0.0041 (95% CI -0.0013, 0.0094). The incremental cost-effectiveness ratio was £1,670 per QALY with a likelihood that stratified care represents cost-effective use of resources of 73% at a willingness-to-pay threshold of £20,000 per QALY. In subgroup analyses, stratified care was only likely to be cost-effective for the subgroup of patients at high risk of poor outcome.
Conclusions
Risk-based stratified primary care for patients with the five common musculoskeletal pain presentations resulted in similar costs and small QALY gains compared to usual, non-stratified primary care overall and therefore, showed inconclusive results overall.
Trial Registration:
ISRCTN Registry ISRCTN15366334; http://www.isrctn.com/ISRCTN15366334.
Barriers to Sustainable Management of Organizational Intellectual Capital
Authors: Gross-Golack Elwira , Brzozowska Anna , Balcerzyk Robert , El Emary Ibrahiem M. M.
Published: April 2024

In the global economy, intellectual capital management is a strategically important resource that affects the market value of organizations. Efficient management of intellectual capital requires the use of new management methods and techniques. One of them is knowledge management, which, in particular, focuses on removing barriers to knowledge sharing. The survey was conducted among employees of the Glogow, Jawor and Trzebnica counties, and the results constitute a pilot study. The conclusions from the collected research results are surprising and imply the need to conduct research on a larger scale in the area of human capital. The collected results provide information to management staff in the field of talent management and knowledge. The results may constitute the basis for developing succession plans, succession plans and employee training. Additionally, the results can help recruiters create profiles of candidates with specific competencies. The main aim of the study was to analyse and evaluate the personnel management process in the Glogow, Jawor and Trzebnica poviats. The use of various research methods made it possible to achieve the intended research goals. The basic research tool used was a survey. Analyses of the literature, research reports, and statistical summaries were treated as a complement to the main research methods. Research and statistical data indicate that among smaller companies in Lower Silesia, there is a need for development programs related to acquiring, collecting, and sharing knowledge. The study identified a number of factors that constitute a significant barrier to the development of employees of the surveyed companies. They allowed us to verify the relationship between the factors that constitute the greatest barrier to the learning process and the impact of the company’s size on it. The relationship between the barriers to intellectual development that constitute the greatest threat to the company and the factors that make it difficult for the company to recruit employees with the highest intellectual capital were also verified.
Users of information and communication technologies in the context of digital inequalities and divides
Authors: Fedotova N. N.
Published: April 2024

The author notes, referring to the opinion of a number of well-known researchers, a significant level of interpenetration of physical and digital reality, as well as the intensity of their interaction. New forms of digital inequality are emerging, which coexist alongside and are interconnected with its traditional manifestations. The concepts of digital divides of the first, second and third levels are not replaced by the concepts of digital inequality, but continue to be used along with them, maintaining their attractiveness. The author believes that one of the most heuristic methodologies for studying digital inequality and digital divides is proposed in the approach of P. Bourdieu, who studied inequality through the prism of forms of capital and the concept of habitus. The empirical basis is grounded on the study Me and My Big Data1, which takes a multidimensional approach to digital inequality in constructing ideal-typical models of digital users. This study reveals the digital divide both through the unequal level of knowledge and skills of UK users, and through the social benefits they receive in social interaction.
How do product responsibility and corporate philanthropy affect firm value?
Authors: Effiong Charles , Inyang William , Mbu-Ogar Geraldine , Otuagoma Florence , Inyang Inyang , Ubi Ije , Okoi Innocent
Published: April 2024

Satisfying the consumer and contributing to societal well-being have been globally acknowledged, and these developments consequently boost corporate image, attract investors, increase stock prices, enhance firm value, and enable industrial and other firms to contribute to national development. This paper examines how product responsibility and philanthropy affect the performance of industrial goods firms in Nigeria. A sample of 7 firms was selected from 24 listed firms after employing a judgmental sampling technique and using secondary data and a quantitative research method. Data validation and analysis were aided by econometric views statistical software, panel data regression, fixed and random effects estimators, stationarity test, cross-section dependence test, Durbin-Watson test, and Hausman test. The study revealed that investment in product responsibility, as evidenced by the rising stock turnover rate, is value-enhancing in Nigeria {B1 = 0.076807, P = 0.0171 or P < 0.05}, while philanthropic donation is value destroying {B1 = –0.369535, P = 0.5817 or P > 0.05}. It was concluded that consumers’ confidence in corporate institutions can enhance corporate value, while investment in philanthropy is not usually value-enhancing when done irresponsibly and non-strategically. The study, therefore, recommended that investment in product responsibility should be consolidated to sustain the rising stock turnover rate, while investment in philanthropy should be done strategically and responsibly to make it value-enhancing.
AcknowledgmentThis research was based on Nnamdi Azikiwe University Ph.D. Dissertation funded by the Tertiary Education Trust Fund (Tetfund), Nigeria. University of Calabar in Nigeria is highly acknowledged for funding the PhD dissertation through its Tetfund platform.
Determinants influencing fraud detection: Role of internal auditors’ quality
Authors: Hariyani Eka , Supriono Supriono , Afriana Hanif Rheny , Paulus Silalahi Sem , Wiguna Meilda
Published: April 2024

Frequent occurrences of fraud take place due to poor fraud prevention and detection. The purpose of this study is to ascertain the impact of internal audit effectiveness and continued professional commitment to fraud detection with internal auditors’ quality as a moderating variable. Seventy-eight questionnaires were distributed to internal auditors and supervisors at the Inspectorate of Riau City, Indonesia, who had at least two years of experience. Structural equation modeling (SEM) 3.0 software was used for the data analysis. According to the study’s findings, the effectiveness of internal control (β = –0.932; p < 0.05) and the effectiveness of internal auditors (β = 1.149; p < 0.05) both have an impact on fraud detection. However, ongoing professional commitment (β = 0.069; p > 0.05) has no impact. Quality of internal auditors does not affect the relationship between the effectiveness of internal audits (β = –0.190; p > 0.05), the effectiveness of internal control (β = 0.114; p > 0.05), continued professional commitment (β = 0.018; p > 0.05), and fraud detection. The findings of this study can be used as guidance for management to enhance the performance of internal auditors and for considerations and assessments for fraud detection in the public sector.
Understanding Synthesis Parameters for Thionation of Phosphonates Associated with the Chemical Weapons Convention through Principal Component Analysis
Authors: Borges Caio , Bernardo Leandro , Cavalcante Samir , Lima Antônio
Published: April 2024

Thiophosphonates, a class of the organophosphate compounds, are of pharmaceutical and agricultural significance. Albeit their broad scope for peaceful uses, they may also be precursors and markers to toxic chemicals, such as the nerve agent VX and other V-series agents, leading to their inclusion into the Annex on Chemicals of the Chemical Weapons Convention (CWC). Considering that they are related to chemical warfare agents and the position of our laboratory as an Organization for the Prohibition of Chemical Weapons (OPCW) Designated Laboratory for analysis of authentic environmental samples, this study aims to contribute to the understanding of the synthesis of thiophosphonates through O,O’-diethyl methylphosphonate conversion to O,O’-diethyl methylphosphonothioate using Lawesson’s reagent, exploring different conditions previously reported by the literature, in order to further build a compound library for CWC verification purposes. Synthesis of the compounds has been carried out in sealed, pressure tubes, adding novelty to the present study. Reactions were followed by gas chromatography and 31P nuclear magnetic resonance, and principal component analysis was employed to understand the intricate factors influencing thiophosphonate synthesis yield as duration, temperature and solvent. The research aims to reinforce or challenge existing scientific knowledge, providing insights into parameters related to phosphonate thionation using Lawesson’s reagent, contributing to a deeper understanding of this chemical reaction.
Cervical Cancer Visual Screening Experience in the Republic of Tajikistan
Authors: Muhsinzoda Nilufar , Bingjie Yuan Alex , Tursunov Rustam
Published: April 2024

OBJECTIVES: To study the results of the first pilot study of organized visual cervical cancer (CC) screening for the detection of precancerous pathology of the cervix in two pilot districts of the Republic of Tajikistan.
STUDY DESIGN: In this cross-sectional study, the target group included healthy women of reproductive age (30-49 years) from Kushoniyon and B. Gafurov Districts who underwent visual screening. The total study population was 72,574 out of which 68,391 (94.3%) visited primary healthcare facilities for visual inspection with Lugol’s Iodine (VILI). A total of 2958 women with suspicious tests for cervical intraepithelial neoplasia (CIN) were identified (4.3%) and sent to the reproductive health care centers for further diagnostics. Post-screening diagnostic tests were performed to specify cervical lesions, which included colposcopy with acetic acid (VIA) visual inspection, cytology, and biopsy with histological examination. HPV testing wasn’t included in the diagnostic protocol due to its high cost.
RESULTS: A total of 164 histologically confirmed cases of CIN were identified (0.25% of number of women screened). The detection rate of precancerous pathology was 26.9 per 100,000 female population, which is 8.2 times higher than the detection rate of CC. All patients regardless of CIN degree underwent loop electrosurgical excision (LEEP)/conization. In the follow-up period (6-48 months), complete recovery after 136 LEEP, 21 conizations, and 7 hysterectomies were observed in 97% (5 recurrences of non-invasive disease).
CONCLUSION: The visual screening showed high efficiency in detecting CIN. The positive experience suggests the implementation of this program nationwide.
Prevalence of Cervical Cancer and Premalignant Cases Based on Pap Smear Screening in Iran in 2022
Authors: Salari Saeideh , Raesi Rasoul , Daneshi Salman , Alian Samakkhah Shohreh , Eshaghi Atefeh
Published: April 2024

Background:

Oral or cervical cancer is caused by the abnormal growth of cells, which in
90% of cases is caused by the human papillomavirus infection.

Objective:

The present study aimed to determine the prevalence of cervical cancer and premalignant
cases based on the results of Pap smears performed in Jiroft health centers in 2022.

Methods:

This cross-sectional study was conducted on 440 women using a census method, and the
demographic information of the people and the results of their Pap smears were recorded using a researcher-
made questionnaire.

Results:

The average age of the investigated women was 37.20 ± 9.09 years, with the highest frequency
in the age group of 30 to 40 years (44.7%), and the average number of previous pregnancies
was 3.06 ± 2.26 times, with the highest frequency observed in the group 1 to 2 times (50.6%). The
average number of abortions was 0.45 ± 0.86, with the highest frequency (70.4%) related to the group
that had no history of abortion. Out of 440 people examined, 6 (1.4%) with a 95% confidence interval
equal to 0.50-2.94% had abnormal Pap smears.

Conclusion:

The number of pregnancies and the increase in the number of abortions can be factors
influencing the incidence of cervical cancer. By performing a Pap smear screening test with early
diagnosis of the disease in the early stages, it is possible to prevent the spread of this disease in the
body and the transformation of these cells into cancer.
Is Necrotizing Enterocolitis and Spontaneous Intestinal Perforation Part
of Same Disease Spectrum - New Insights?
Authors: Garg Parvesh Mohan , Garg Padma P. , Shenberger Jeffrey S.
Published: April 2024

The diagnosis of NEC is based on the presence of pneumatosis, dilated bowel loops,
portal venous gas, or pneumoperitoneum on the abdominal x-ray. Published studies suggest that
the appearance of pneumatosis most likely depends on the gestational age, with a shift occurring
between 27-28 weeks. For infants of gestational age under 27 weeks, pneumoperitoneum is the
most likely presentation of bowel injury due to the thin bowel wall and the colonization of the gut
with the non-gas-producing bacteria. Assessment of postoperative morbidity and white matter injury
on the brain MRI at term equivalent age in a cohort of preterm infants failed to identify differences
between SIP and NEC groups when confirmed by histology. These findings illustrate the difficulty
in conclusively identifying cases as SIP or NEC, particularly when gestational age is considered
and raise speculation that both conditions lie on the same spectrum of intestinal injury.
18F-DGPET/CT Imaging of Ovarian Yolk Sac Tumor in a Woman after
Induction of Labor: A Case Report
Authors: Jin Ai-Fang , Luo Zhe-Huang
Published: April 2024

Introduction::

Ovarian yolk sac tumor (OYST) during pregnancy is rare and usually missed. There are few PET/CT studies on OYST in the literature. We
reported a case of OYST detected by 18F-FDG PET/CT in a woman after induction of labor.

Case Presentation::

A 19-year-old woman after induction of labor because of severe malformation presented with abdominopelvic mass, laboratory tests revealed
significantly elevated serum alpha-fetoprotein (AFP) level and elevated carbohydrate antigen 125 level. Abdomino-pelvic CT showed a cysticsolid
mass of 82×152×167mm arising from the right ovary with abundant intratumoral vessels and intense enhancement in the solid part. Further
evaluation of 18F-FDG PET/CT imaging showed significantly increased 18FDG uptake (SUVmax7.7) by the solid component of the ovarian mass
and slight 18FDG-avid perihepatic effusion. The mass was resected and was confirmed to be the right OYST, After four courses of chemotherapy,
the patient was followed up by PET/CT and had a complete metabolic response.

Discussion::

18F-FDG PET/CT is a useful imaging modality for diagnosis and evaluation of OYST.
Ketamine
Authors: Krishnan Jayalakshmi
Published: April 2024

Ketamine is a dissociative anaesthetic drug that functions as a blocker of
NMDA receptors. Moreover, it causes a neurostimulatory effect and is also used as a
sedative. Ketamine has many names, such as Special K, Green K, Super K, Super Acid,
Jet, and Cat Valium. Ketamine is used as a recreational drug in clubs, also known as a
“club drug”. As a recreational drug, it causes the patient to experience delirium and an
altered state of consciousness. Patients with cardiovascular disabilities can also be
given ketamine as a sedative. Ketamine can be taken in various methods, such as
orally, rectally, intranasally, IV, IM, or intrathecally. Ketamine abuse can lead to
secondary renal damage and upper gastrointestinal symptoms.
Drug Addiction Mechanisms in the Brain
Authors: Krishnan Jayalakshmi
Published: April 2024

Drug Addiction Mechanisms in the Brain explores the fascinating world of drug substances and their effects on the brain. This book provides a comprehensive overview of the ten major substances that contribute to drug addiction Information about each substance is presented in a specific chapter, shedding light on their biochemical mechanisms and physiological effects. From the stimulating effects of cocaine to the sedative properties of heroin, and the hallucinogenic experiences induced by LSD, the book takes the reader through the intricate pathways of addiction. Other substances covered in the book include alcohol, nicotine, MDMA, METH, morphine, ketamine, and fentanyl. Readers will gain an understanding about neurochemical alterations in the brain Anyone looking for interesting knowledge about the addictive nature of common drugs and their complex interplay with the brain will find this book informative.
La Internacionalización Empresarial Desde La Estrategia De Innovación: Caso Tecnoglass
Authors:   Politécnico de la Costa Atlántica, Del Valle Villarreal Neil
Published: April 2024

Introducción: En Colombia, la internacionalización empresarial ha sido un proceso lento dada la marcada primarización económica. En 1991, el Gobierno intenta implementar el programa de apertura económica, momento en el que la economía nacional intenta, a partir de los acuerdos de comercio internacional suscritos por el Gobierno, insertarse en el Nuevo Orden Económico Internacional (NOEI). No obstante, Tecnoglass logró penetrar en el mercado internacional a partir de una férrea estrategia de innovación aplicada a la fabricación del vidrio. Objetivo: Analizar el proceso de internacionalización empresarial en el país a partir del caso de Tecnoglass, empresa colombiana ubicada en Barranquilla. Lo anterior basado en sus innovaciones y el espíritu emprendedor característico del inmigrante árabe de la Costa Caribe. Metodología: Se parte del estudio de las políticas de apertura económica implementadas en Colombia desde 1991 y se seleccionan otros trabajos respecto de la participación de la compañía en los mercados internacionales bajo un enfoque mixto de investigación. Resultados: Se concluye que el éxito en su estrategia de internacionalización está centrado esencialmente en la innovación. Conclusiones: El éxito de Tecnoglass no reside en las prerrogativas o beneficios del Tratado de Libre Comercio (TLC) suscrito con los Estados Unidos.
Toegankelijke en snelle procedures : Kan de Omgevingswet beter?
Authors:   University of Groningen, Tolsma Hanna
Published: April 2024

Hanna Tolsma is in 2020 benoemd tot hoogleraar Besluitvorming en rechtsbescherming in het omgevingsrecht (Aletta Jacobs-leerstoel). Zij promoveerde in 2008 op het onderwerp Bemiddelend Bestuur. Juridische aspecten van bemiddeling bij de bestuurlijke besluitvorming. Hierna volgde een door NWO gefinancierd postdocproject. De omgevingsvergunning met integrale belangenafweging: een verkenning van de juridische mogelijkheden. Zij publiceert over algemeen bestuurs(proces)recht en het omgevingsrecht. Haar onderzoek gaat over de juridische aspecten van de procedure van besluitvorming (participatie), de reikwijdte van de belangenafweging bij besluitvorming en de toegang tot en rol van de rechter. Sinds 2023 maakt Hanna deel uit van de Raad voor de leefomgeving en infrastructuur (het strategische adviescollege voor regering en parlement op het brede domein van de fysieke leefomgeving) en de Evaluatiecommissie Omgevingswet.
Serbian Version of the eHealth Literacy Questionnaire (eHLQ): Translation, Cultural Adaptation, and Validation Study Among Primary Health Care Users
Authors: Vujkovic Branko , Brkovic Voin , Pajičić Ana , Pavlovic Vedrana , Stanisavljevic Dejana , Krajnović Dušanka , Jovic Vranes Aleksandra
Published: April 2024

Background

As digital health services are increasingly developing and becoming more interactive in Serbia, a comprehensive instrument for measuring eHealth literacy (EHL) is needed.

Objective

This study aimed to translate, culturally adapt, and investigate the psychometric properties of the Serbian version of the eHealth Literacy Questionnaire (eHLQ); to evaluate EHL in the population of primary health care (PHC) users in Serbia; and to explore factors associated with their EHL.

Methods

The validation study was conducted in 8 PHC centers in the territory of the Mačva district in Western Serbia. A stratified sampling method was used to obtain a representative sample. The Translation Integrity Procedure was followed to adapt the questionnaire to the Serbian language. The psychometric properties of the Serbian version of the eHLQ were analyzed through the examination of factorial structure, internal consistency, and test-retest reliability. Descriptive statistics were calculated to determine participant characteristics. Differences between groups were tested by the 2-tailed Students t test and ANOVA. Univariable and multivariable linear regression analyses were used to determine factors related to EHL.

Results

A total of 475 PHC users were enrolled. The mean age was 51.0 (SD 17.3; range 19-94) years, and most participants were female (328/475, 69.1%). Confirmatory factor analysis validated the 7-factor structure of the questionnaire. Values for incremental fit index (0.96) and comparative fit index (0.95) were above the cutoff of ≥0.95. The root mean square error of approximation value of 0.05 was below the suggested value of ≤0.06. Cronbach α of the entire scale was 0.95, indicating excellent scale reliability, with Cronbach α ranging from 0.81 to 0.90 for domains. The intraclass correlation coefficient ranged from 0.63 to 0.82, indicating moderate to good test-retest reliability. The highest EHL mean scores were obtained for the understanding of health concepts and language (mean 2.86, SD 0.32) and feel safe and in control (mean 2.89, SD 0.33) domains. Statistically significant differences (all P<.05) for all 7 eHLQ scores were observed for age, education, perceived material status, perceived health status, searching for health information on the internet, and occupation (except domain 4). In multivariable regression models, searching for health information on the internet and being aged younger than 65 years were associated with higher values of all domain scores except the domain feel safe and in control for variable age.

Conclusions

This study demonstrates that the Serbian version of the eHLQ can be a useful tool in the measurement of EHL and in the planning of digital health interventions at the population and individual level due to its strong psychometric properties in the Serbian context.
Experimental Study of Partial Replacement of Cement with GGBS and Silico Manganese with M30 Grade Concrete
Authors: Himangeswari M. , Revathi Ch. , Rajkumar K. T , Kumar G. Hemanth , Ram N. Jai , Vasanthi Y.
Published: April 2024

Abstract: Cement in concrete is a several disadvantages when used without any replacement to it in concrete such as high carbon footprint high cost of construction, and low tensile strength. To address these materials such as GGBS, and silico manganese can be used, designing concrete mixtures with lower cement content can reduce the carbon print, cost, and potential cracking, resulting in more sustainable, cost effective and durable concrete structures. In our project we are going to use GGBS (Ground granulated blast furnace slag) and silico manganese as a replacement of materials to cement in varying percentage. GGBS and silico manganese cementitious properties and can particularly replace cement in concrete mixtures. It improves the durability, workability, and strength of concrete. GGBS has a lower carbon footprint than traditional cement, making it an environmentally friendly alternative. Silico manganese is the process involves high temperature to melt the raw materials and reduce them to their metallic forms. This project represents the results of an experimental investigations accomplish to understand the suitability of GGBS and Silico manganese on strength of referral concrete M30 Grade concrete was prepared by replacing PART OF 0%, 30%, 40%, 50% (by weight of cement) for GGBS and Silico manganese. Fresh concrete was properties viz. slump cone was carried out. Strength of concrete were determined by performing compressive strength test on (150mm×150mm×150mm) size cubes.
Revolutionizing Collaborative Learning with Virtual Notes Sharing Platforms: An Empirical Study in Educational Environments
Authors: Pawar Vedant Vijay
Published: April 2024

Abstract: In the era of technology-driven education, this research paper explores the transformative potential of virtual notessharing platforms in fostering collaborative learning within educational environments. The study aims to delve into the intricate interplay between technology and pedagogy, emphasizing how these digital platforms can revolutionize the traditional classroom setting. By offering an empirical analysis of the utilization and impact of such platforms in various educational settings, the research uncovers novel insights into their role in enhancing student engagement, participation, and knowledge retention. The paper employs a mixed-methods approach, utilizing both qualitative and quantitative data gathered from surveys, interviews, and case studies across diverse educational institutions. The findings illustrate a significant increase in student collaboration and active learning, underscoring the pivotal role of these platforms in promoting a dynamic and interactive educational atmosphere.
A Research Paper of a Medical Chatbot using Llama 2
Authors: Sasan Adit Pal Singh
Published: April 2024

Abstract: Embracing the knowledge era in healthcare, this research explores a novel medical chatbot empowered by the formidable Llama 2 language model. Transcending the limitations of conventional chatbots, it leverages a trifecta of technological prowess: Llama 2's vast knowledge base and nuanced understanding of medical language enable pinpointaccurate responses, even to intricate inquiries. Chainlit's web framework sculpts an intuitive interface, empowering users to effortlessly navigate and visualize pertinent medical information. Faiss, the master of information retrieval, swiftly delivers curated medical resources tailored to the user's specific needs This research paves the way for a future where medical chatbots, wielding the power of knowledge, empower individuals to navigate the complexities of healthcare with confidence.
SafeGuard: IOT - Based Health and Soldier Tracking System
Authors: Meshram R. S. , Kapse H. V. , Nangare O. U. , Shinde S. A. , Pawar K. A.
Published: April 2024

Abstract: These days, a nation's battleground is essential to its security. The soldiers in the army play a major role. There have been several actions made to protect the soldiers. Therefore, numerous equipment is mounted on horses to monitor their health in order to ensure their safety. Bioprocess systems facilitate low-cost wearable, discreet health monitoring options by combining several biosensor types, transmission technologies, and processing powers. GPS is used to determine latitude and longitude, making it easy to determine the soldier's direction. In order for base stations to be able to monitor their soldiers in real time, these devices are being attached to weapons and clothing. The Israeli Army, for example, is investigating the possibility of embedding GPS trackers inside soldiers' vests and uniforms. Several intelligent sensors that are affixed to a soldier's body are employed in this system. The base station will use a wireless connection to provide connectivity. The GSM module that the soldiers would carry will aid in facilitating their contact with the army station base. The idea of tracking a soldier and learning about his situation during a fight is the focus of the project's proposed system. Software and hardware are integrated to implement the system.
Multiple Disease Detection System
Authors: Parbate Pranay , Thombare Dhairyashil , Yerkal Tushar , Varpe Adarsh , Reddy Prof. Suresh
Published: April 2024

Abstract: In the realm of healthcare, the early detection of multiple diseases presents a formidable challenge but holds immense potential for improving patient outcomes. This paper proposes an integrative approach for the simultaneous detection of four prevalent diseases: heart disease, Parkinson's disease, diabetes, and skin cancer. Leveraging advanced machine learning techniques, our framework encompasses data preprocessing methods for cleaning and normalization, feature selection strategies to extract discriminative features from heterogeneous medical datasets, and ensemble classification models for accurate disease prediction. Real-world datasets encompassing diverse medical conditions are utilized to evaluate the efficacy of the proposed framework. Experimental results demonstrate its superior performance in terms of accuracy, sensitivity, and specificity compared to conventional methods. This framework stands as a testament to the transformative potential of technology in healthcare, facilitating early detection and intervention across multiple diseases, thereby enhancing patient care and quality of life.
Quantum advantage in temporally flat measurement-based quantum computation
Authors: Oliveira Michael de , Barbosa Luís S. , Galvão Ernesto F.
Published: April 2024

Several classes of quantum circuits have been shown to provide a quantum computational advantage under certain assumptions. The study of ever more restricted classes of quantum circuits capable of quantum advantage is motivated by possible simplifications in experimental demonstrations. In this paper we study the efficiency of measurement-based quantum computation with a completely flat temporal ordering of measurements. We propose new constructions for the deterministic computation of arbitrary Boolean functions, drawing on correlations present in multi-qubit Greenberger, Horne, and Zeilinger (GHZ) states. We characterize the necessary measurement complexity using the Clifford hierarchy, and also generally decrease the number of qubits needed with respect to previous constructions. In particular, we identify a family of Boolean functions for which deterministic evaluation using non-adaptive MBQC is possible, featuring quantum advantage in width and number of gates with respect to classical circuits.
Optimizing Variational Quantum Algorithms with qBang: Efficiently Interweaving Metric and Momentum to Navigate Flat Energy Landscapes
Authors: Fitzek David , Jonsson Robert S. , Dobrautz Werner , Schäfer Christian
Published: April 2024

Variational quantum algorithms (VQAs) represent a promising approach to utilizing current quantum computing infrastructures. VQAs are based on a parameterized quantum circuit optimized in a closed loop via a classical algorithm. This hybrid approach reduces the quantum processing unit load but comes at the cost of a classical optimization that can feature a flat energy landscape. Existing optimization techniques, including either imaginary time-propagation, natural gradient, or momentum-based approaches, are promising candidates but place either a significant burden on the quantum device or suffer frequently from slow convergence. In this work, we propose the quantum Broyden adaptive natural gradient (qBang) approach, a novel optimizer that aims to distill the best aspects of existing approaches. By employing the Broyden approach to approximate updates in the Fisher information matrix and combining it with a momentum-based algorithm, qBang reduces quantum-resource requirements while performing better than more resource-demanding alternatives. Benchmarks for the barren plateau, quantum chemistry, and the max-cut problem demonstrate an overall stable performance with a clear improvement over existing techniques in the case of flat (but not exponentially flat) optimization landscapes. qBang introduces a new development strategy for gradient-based VQAs with a plethora of possible improvements.
Potential impact of climate change-induced alterations on pyroptotic cell death in animal cells
Authors: BERKEL Caglar
Published: April 2024

Climate change-induced alterations in temperature variation, ozone
exposure, water salinity and acidification, and hypoxia might influence
immunity in diverse animal groups from fish to mammals. Pyroptosis is a
type of lytic pro-inflammatory programmed cell death, which participates
in the innate immune response, and is involved in multiple diseases
characterized by inflammation and cell death, mostly studied in human
cells. Here, I review previous research pointing to the potential impact
of climate change on pyroptotic cell death in different animal cells. I
propose that temperature-, ozone exposure-, salinity-, acidification-
and hypoxia-induced pyroptotic cell death should be better understood to
be able to mitigate the adverse effects of climate change on animal
physiology. This is of high importance considering the increasing
frequency of climate-based changes in these environmental parameters,
and the critical function of pyroptosis in immune responses of animals.
Structural Relationships among Parental Parenting Stress, Achievement Pressure, and Children's School Adaptation : The Mediating Effect of Self-Esteem
Authors:   The Korea Associantion For Early Childhood Education Administration, Min Mi-Hee
Published: April 2024

Difficulties in adapting to school in the upper grades of elementary school can lead to interpersonal conflicts and psychological problems, leading to social maladjustment in adulthood as well as in middle and high school. This study attempts to examine the mediating effect of self-esteem in the relationship between parental parenting stress, achievement pressure and children's school adaptation. For this purpose, 1,217 sixth graders(615 boys and 602 girls) in the 13th year(2020) data from PSKC(KICCE) were studied. The results of the study analyzed the structural equation model. First, parental parenting stress had a significant impact on children’s self-esteem and school adaptation, achievement pressure has a significant impact on children’s self-esteem, and children’s self-esteem had a significant impact on school adaptation. But achievement pressure was found to have no significant impact on children's school adaptation. Second, the impact of parental parenting stress on children's school adaptation showed a significant indirect effect through children's self-esteem, and the impact of achievement pressure on children's school adaptation showed a significant indirect effect through children's self-esteem. This is significant in that it presented a theoretical basis for the importance of parental education to reduce parenting stress and help parents adapt to school for senior elementary school children entering adolescence.
Clinical trial of tolerability, safety and immunogenicity of influenza inactivated split-vaccine Flu-M in children aged 6 to 17 years
Authors: Korolyuk A. M. , Kraeva V. N. , Zazimko L. A. , Koromzin Yu. A. , Ruzanova E. A. , Savina N. N. , Ryskova E. V.
Published: April 2024

Purpose. To evaluate the tolerability, safety and immunogenicity of influenza inactivated split flu vaccine Flu-M during single immunization of children aged 6 to 17 years.

Materials and methods. A multicentre double-blind comparative randomised clinical trial of influenza inactivated split vaccine Flu-M for immunisation of children aged 6 to 17 years (the reference agent – Ultrix vaccine) was conducted. Children aged 12 to 17 years inclusive (300 children) were studied at stage I, and children aged 6 to 12 years (300 children) at stage II. Volunteers of each age category were randomised 1:1 into 2 groups comparable in sex and age, one was vaccinated with Flu-M vaccine and the other with Ultrix vaccine. The follow-up, including various laboratory and clinical tests, lasted for 28 days from the time of vaccination.

Results. Both vaccines were well tolerated by children aged 12 to 17 years and by children aged 6 to 12 years. There were no severe or serious adverse events. By all criteria of immunogenicity evaluation, vaccine Flu-M was not inferior to the comparison vaccine Ultrix.

Conclusion. Influenza inactivated split Flu-M vaccine produced by SPbNIIVS is approved for use for specific prophylaxis of influenza in children aged 6 to 17 years in the Russian Federation, the Republic of Belarus, Latin America and the Caribbean.The trial is registered at ClinicalTrials. gov (NCT 05317767).
HIV-infection in the arctic zone of the republic of Sakha (Yakutia): status, challenges and prospects
Authors: Zolotareva A. G. , Sleptsova S. S. , Sleptsov S. S. , Burtseva T. E.
Published: April 2024

The stable increase in morbidity and mortality of the population of the Republic of Sakha (Yakutia) from causes related to HIV infection indicates an unfavorable epidemiological situation in the region. Especially it affects industrial areas and large settlements of Yakutia. In the near future, an increase in the number of HIV-infected patients in the republic is expected, which is alarming. The HIV epidemiological situation is aggravated by the unequal distribution within the region with extremal environmental conditions and underdeveloped transport infrastructure. All this makes it much more difficult to provide medical care to this category of people, some of whom later move outside the territory of the Republic.

Aim: Improvement of effective preventive measures and organization of medical care in the Arctic regions of the Republic of Sakha (Yakutia) based on the analysis of morbidity and mortality from HIV infection.

Materials and methods: The materials of official statistics of the Department of the Federal Service for Supervision of Consumer Rights Protection and Human Welfare in RS(Ya) and data from official governmental medical reports (forms № 61 and № 4) were used in the work.

Results: The number of HIV-infected people on the territory of the Republic of Sakha (Yakutia), including in the Arctic regions, is growing in recent years. Thus, from 1998 to 2022, 77 new cases of HIV infection were detected in the Arctic regions, more than half of which (54.5%) were registered in the period from 2016 to 2022. The tendency of growth of the indigenous population affected by HIV infection, including in remote areas of the region, that dictates the need for mandatory HIV screening of all persons arriving for shift work both from neighboring countries and from other regions of the Russian Federation.

Conclusion: Preventive measures, HIV testing and organization of medical care are the basis for effective fight against this disease, especially in remote Arctic regions of the Republic of Sakha (Yakutia).
Fluorosis dental, etiología, diagnóstico y tratamiento
Authors:   Investigador Independiente, Salazar Santamaría Mónica Michelle , Ortega Moncayo Kenny Noé ,   Investigador Independiente, Chávez López Milena Fernanda ,   Investigador Independiente, Fiallos Ramos Víctor Fabián ,   Investigador Independiente, Yépez Chávez Eimy Pamela ,   Investigador Independiente
Published: April 2024

La fluorosis dental es una condición en la que la estructura dental sufre de hipomineralización debido a una ingesta excesiva de flúor en el organismo. En el caso de la dentición decidua, es importante diagnosticarla tempranamente, ya que puede predecir la aparición de lesiones en los dientes permanentes. El propósito de esta revisión es describir la evidencia científica sobre la fluorosis dental, incluyendo su etiología, factores relacionados, prevalencia, diagnóstico y tratamiento. Se realizaron búsquedas electrónicas en las bases de datos PubMed/Medline, EbscoHost y ScienceDirect. Se encontró que el desarrollo de fluorosis dental en la dentición decidua como en la dentición permanente está relacionado con la ingesta de múltiples fuentes de flúor, principalmente agua potable, alimentos, fórmulas infantiles, suplementos y el uso de dentífricos fluorados en dosis inadecuadas. También se encontró que algunos factores prenatales, como vivir en terrenos montañosos o de gran altitud y habitar cerca de minas de carbón, también pueden estar asociados. La prevalencia de fluorosis dental reportada en los estudios varió entre el 6,2% y el 96,6%, dependiendo principalmente de la concentración de flúor en el agua potable. El diagnóstico de la fluorosis dental en la dentición se basa en características como la localización, apariencia, extensión y color de las lesiones, realizando un diagnóstico diferencial con otros tipos de defectos en el esmalte y la dentina. El tratamiento de las lesiones dependerá de la gravedad del defecto y las condiciones individuales del paciente.
reforma trabalhista - lei 13.467/17
Authors: Rodrigues Winicius da Silva
Published: April 2024

Com o advento da Lei 13.467/17, a famigerada “Reforma Trabalhista”, foram introjetados no ordenamento do jurídico uma série de alterações, seja no campo do direito material do trabalho seja no campo do direito processual. Dentre as referidas alterações está o parágrafo 2º, do art. 8º da CLT, que estabelece que “Súmulas e outros enunciados de jurisprudência editados pelo Tribunal Superior do Trabalho e pelos Tribunais Regionais do Trabalho não poderão restringir direitos legalmente previstos nem criar obrigações que não estejam previstas em lei.” A dicção do citado dispositivo, em uma perfunctória análise, pode induzir à conclusão que o legislador pretendeu tolher/impedir a interpretação dos magistrados no momento da aplicação do direito; culminando, assim, em uma volta ao positivismo exegético (juízes como mero aplicadores de regras). O objetivo deste trabalho é demostrar que, a despeito do receio apresentado pelo poder judiciário, o positivismo exegético foi há muito tempo superado pelo pós-positivismo, sendo que a inovação legislativa deve ser analisada à luz da Teoria do Direito como Integridade de Ronald Dworkin; evitando, assim, somente a discricionariedade judicial (Ativismo) no momento da aplicação do direito, mas não a interpretação do julgador do direito positivado.