bluuebunny/crossref_metadata_2025 huggingface dataset:
Peltier Cell Integration in Packaging Design for Minimizing Energy Consumption and Temperature Variation during Refrigerated Transport
Authors: Fernandes Pedro , Gaspar Pedro D. , Silva Pedro D.
Published: July 2023

This study proposes an innovative approach to reduce temperature fluctuations in refrigerated transport during loading and unloading, aiming to minimize food waste and optimize energy consumption in the food supply chain. The solution involves integrating Peltier cells into secondary and tertiary packaging to improve system efficiency and minimize temperature variations. Four distinct tests were conducted: a reference test, continuous Peltier system operation, and two intermittent cooling tests for the hot side of the cells. The results highlight the effectiveness of this approach, particularly in the fourth test where the average final food temperature decreased from 3.2 °C (reference test) to 2.8 °C. Integrating Peltier cells into packaging shows potential benefits in minimizing food waste, reducing energy consumption, and associated emissions during refrigerated transport. This research contributes to the sustainable design and manufacturing of packaging systems, specifically in the context of refrigerated transport. By maintaining a consistent temperature environment during the critical loading and unloading phases, incorporating Peltier cells enhances the overall performance and efficiency of refrigerated transport system. These results point out the significance of exploring innovative solutions for sustainable food preservation and the decrease of waste all along the food supply chain.
The Predictive Value of Lung Ultrasound Score on Hemodynamically Significant Patent Ductus Arteriosus among Neonates ≤25 Weeks
Authors: Zong Haifeng , Huang Zhifeng , Lin Bingchun , Zhao Jie , Fu Yongping , Yu Yanliang , Sun Hongyan , Yang Chuanzhong
Published: July 2023

Lung ultrasound (LU) is increasingly used to diagnose and monitor neonatal pulmonary disorders; however, its role in hemodynamically significant patent ductus arteriosus (hsPDA) has not been elucidated. This prospective study investigated the predictive value of the LU score (LUS) for hsPDA in preterm infants with gestational age (GA) ≤ 25 weeks. Preterm infants with GA ≤ 25 weeks were enrolled in this study. LU was conducted on the fourth day of life (DOL). Six lung regions in every lung were scanned, with each region rated as 0–4 points. The performance of the LUS in predicting hsPDA among infants aged ≤25 weeks was analyzed by plotting the receiver operating characteristic (ROC) curve. A total of 81 infants were included in this study. GA, birth weight (BW), gender, Apgar score, delivery mode, antenatal steroids, meconium-stained amniotic fluid, premature rapture of membrane, and early-onset sepsis were not significantly different, but infants in the hsPDA group had increased LUS (38.2 ± 2.8 vs. 30.3 ± 4.3, p < 0.001) compared with non-hsPDA group. The area under the ROC curve (AUC) value of the LUS on the fourth DOL was 0.94 (95% CI: 0.93–0.99) in predicting hsPDA. The LUS threshold at 33 achieved 89% sensitivity and 83% specificity, with the positive and negative predictive values (PPV and NPV) being 87 and 86%, respectively. The LUS can predict hsPDA in extremely preterm infants at an early stage.
Prognostic Significance of Preoperative NLR, MLR, and PLR Values in Predicting the Outcome of Primary Cytoreductive Surgery in Serous Epithelial Ovarian Cancer
Authors: Kovács Anna Rebeka , Sulina Anita , Kovács Kincső Sára , Lukács Luca , Török Péter , Lampé Rudolf
Published: July 2023

(1) The degree of cytoreduction achieved during primary debulking surgery (PDS) is an important prognostic factor for the survival of patients with epithelial ovarian cancer (EOC). Our aim was to investigate the prognostic value of preoperative laboratory parameters for the outcome of PDS. (2) We analyzed the preoperative laboratory parameters of 150 serous EOC patients who underwent PDS between 2006 and 2013. Receiver operating characteristic (ROC) curve analysis was used to determine the optimal cut-off values of the variables for predicting the PDS outcome. We used binary logistic regression to examine the independent predictive value of the factors for incomplete cytoreduction. (3) Among the parameters, we established optimal cut-off values for cancer antigen (Ca)-125, neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and platelet-to-lymphocyte ratio (PLR) to predict the outcome of PDS. The results of binary logistic regression showed that stage (FIGO III-IV), MLR (>0.305), and Ca-125 (>169.15 kU/L) were independent significant predictors of the degree of tumor reduction achieved during PDS. (4) In the future, MLR, especially in combination with other parameters, may be useful in determining prognosis and selecting the best treatment option (PDS or neoadjuvant chemotherapy + interval debulking surgery) for ovarian cancer patients.
Efficient Fingerprinting Attack on Web Applications: An Adaptive Symbolization Approach
Authors: Yang Xue , Xu Jian , Li Guojun
Published: July 2023

Website fingerprinting is valuable for many security solutions as it provides insights into applications that are active on the network. Unfortunately, the existing techniques primarily focus on fingerprinting individual webpages instead of webpage transitions. However, it is a common scenario for users to follow hyperlinks to carry out their actions. In this paper, an adaptive symbolization method based on packet distribution information is proposed to represent network traffic. The Profile Hidden Markov Model (PHMM exploits positional information contained in network traffic sequences and is sensitive to webpage transitional information) is used to construct users’ action patterns. We also construct user role models to represent different kinds of users and apply them to our web application identification framework to uncover more information. The experimental results demonstrate that compared to the equal interval and K-means symbolization algorithms, the adaptive symbolization method retains the maximum amount of information and is less time-consuming. The PHMM-based user action identification method has higher accuracy than the existing traditional classifiers do.
A Privacy Robust Aggregation Method Based on Federated Learning in the IoT
Authors: Li Qingtie , Wang Xuemei , Ren Shougang
Published: July 2023

Federated learning has been widely applied because it enables a large number of IoT devices to conduct collaborative training while maintaining private data localization. However, the security risks and threats faced by federated learning in IoT applications are becoming increasingly prominent. Except for direct data leakage, there is also a need to face threats that attackers interpret gradients and infer private information. This paper proposes a Privacy Robust Aggregation Based on Federated Learning (PBA), which can be applied to multiple server scenarios. PBA filters outliers by using the approximate Euclidean distance calculated from binary sequences and the 3σ criterion. Then, this paper provides correctness analysis and computational complexity analysis on the aggregation process of PBA. Moreover, the performance of PBA is evaluated concerning ensuring privacy and robustness in this paper. The results indicate that PBA can resist Byzantine attacks and a state-of-the-art privacy inference, which means that PBA can ensure privacy and robustness.
A Survey on Fluorinated Greenhouse Gases in Taiwan: Emission Trends, Regulatory Strategies, and Abatement Technologies
Authors: Tsai Wen-Tien , Tsai Chi-Hung
Published: July 2023

Fluorinated greenhouse gases (F-gases), including hydrofluorocarbons (HFCs), perfluorocarbons (PFCs), sulfur hexafluoride (SF6), and nitrogen trifluoride (NF3), are used in a variety of applications, but they are potent greenhouse gases (GHGs). Therefore, they have been blanketed into the list of items to be phased out under international protocols or treaties. During the desk research, the updated statistics of Taiwan’s National Inventory Report (NIR) were used to analyze the trends of F-gases (i.e., HFCs, PFCs, SF6, and NF3) emissions during the period of 2000–2020. Furthermore, the regulatory strategies and measures for the reduction of the four F-gas emissions will be summarized to be in accordance with the national and international regulations. With the rapid development in the electronics industry, the total F-gas emissions indicate a significant increase from 2462 kilotons of carbon dioxide equivalents (CO2eq) in 2000 to the peak value (i.e., 12,643 kilotons) of CO2eq in 2004. However, it sharply decreased from 10,284 kilotons of CO2eq in 2005 to 3906 kilotons of CO2eq in 2020 due to the ongoing efforts of the regulatory requirements and the industry’s voluntary reduction in time sequence. It was also found that the most commonly used method for controlling the emissions of F-gases from the semiconductor and optoelectronic industries in Taiwan is based on the thermal destruction-local scrubbing method.
Tuberculosis Notification in Jordan, 2016–2020
Authors: Khader Yousef , Abaza Hiba , Satyanarayana Srinath , Abu Rumman Ahmad Saleh , Alyousfi Mohamad Nihad
Published: July 2023

The burden of tuberculosis (TB) in Jordan is largely unknown due to the paucity of high-quality data, under-reporting, and a lack of good quality vital registration system. This study aimed to assess the characteristics of TB patients in Jordan, determine the TB notification rate and assess the trend of TB notification in Jordan between 2016 and 2020. Methods: This study analyzed the TB Surveillance data in Jordan for the period 2016–2020. The obtained data included information on age, gender, nationality, marital status, date of symptoms onset and date of diagnosis, and site of TB. Results: During the period 2016–2020, a total of 1711 patients (989 women and 722 men) were diagnosed with and treated for tuberculosis. The mean (SD) age of patients was 30.1 (17.2) years. Almost half of them (48.4%) were Jordanians. The majority of non-Jordanian patients were from Syria, Philippines, and Bangladesh. Two thirds of patients (66.0%) had pulmonary TB and 34.0% had extra-pulmonary TB. Almost half (50.7%) of the patients were diagnosed within one month of the symptoms’ onset. The average annual TB notification rate during 2016–2020 was 3.32 per 100,000 pop (4.08 per 100,000 women and 2.64 per 100,000 men). The average annual standardized notification rate was 4.13 per 100,000 pop (4.52 per 100,000 women and 3.52 per 100,000 men). The overall age-standardized notification rate increased from 3.88 per 100,000 pop in 2016 to 4.58 per 100,000 pop in 2019 and declined to 2.46 per 100,000 pop in 2020. The trend in TB notification differed significantly according to gender. While the notification increased in the last three years among women, it decreased significantly among men. Conclusions: While TB notification increased in the last three years among women, it decreased significantly among men. There is a need to ensure that the national TB plans set clear targets for reducing the burden of TB.
Wildfire and Climate Impacts Tree Hollow Density in a Temperate Australian Forest
Authors: Gordon Christopher E. , Stares Mitchell G. , Bendall Eli R. , Bradstock Ross A.
Published: July 2023

Tree hollows are an important landscape resource used by fauna for shelter, nesting, and predator avoidance. In fire-prone landscapes, wildfire and climate may impact hollow dynamics; however, assessments of their concurrent impacts are rare. We conducted a field survey at 80 sites in the Sydney Basin bioregion (Australia) to understand how fire frequency, fire severity, mean annual temperature, and mean annual precipitation concurrently impacted the site-density of small- (<5 cm entry width), medium- (5–10 cm entry width) and large-size (>10 cm entry width) tree hollows and tree basal scars (which mediate hollow formation via invertebrate access to heartwood), when tree-size and dead/live status were considered. A unimodal relationship occurred between medium- and large-sized hollow densities and fire frequency and severity, respectively, with hollow densities greatest at intermediate frequencies/severities. Increases of 1.82, 1.43, and 1.17 hollows per site were observed between the 1 (reference) and 2, 2 and 3, and 3 and >3 fire frequency categories. Increases of 1.26, 1.75 and 0.75 hollows per site were observed between the low (reference) and moderate, moderate and high, and high and very high fire severity categories. Fire severity was also positively associated with basal scar density, with increases of 2.52, 8.15, and 8.47 trees per site between the low (reference) and moderate, moderate and high, and high and very high categories. A weak positive and stronger negative association was observed between mean annual temperature and small-sized hollow and basal scar density, respectively. Dead and medium-sized tree density was positively associated with medium-sized hollow and basal scar tree density, respectively. Collectively, our results suggest that wildfires, and in some cases climate, have diverse and size-specific impacts on tree hollow and basal scar density. Our results imply that fire regimes that allow for moderately severe wildfire will promote larger-sized tree hollows, which are a limiting resource for many fauna species.
Muscle Transcriptome Analysis Reveals Molecular Mechanisms of Superior Growth Performance in Kuruma Shrimp, Marsupenaeus japonicus
Authors: Wang Panpan , Yu Fei , Li Xinyang , Xie Shumin , Wang Lei , Zhu Jiawei , Zhou Xinlei , Zhou Xinyi , Yan Binlun , Gao Huan , Xing Chaofan
Published: July 2023

During the cultivation of Marsupenaeus japonicus, there are often obvious differences in the growth within the same family under the same food, water quality, and environment, which greatly affects cultivation efficiency. To explore the molecular mechanism of this growth difference, this study used RNA-seq technology to compare the transcriptomes of M. japonicus individuals with significant growth differences from the same family. A total of 1375 differentially expressed genes were identified, of which 1109 were upregulated and 266 were downregulated. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were performed on the differentially expressed genes, and the results showed that growth-related processes, including chitin metabolism, chitin-binding amino sugar metabolism, and antioxidant processes, including response to oxidative stress, peroxidase activity, antioxidant activity, and peroxidase activity, showed significant differences between the large-size and small-size groups. The expression levels of some differentially expressed genes, such as cuticular protein, low-density lipoprotein receptor, ecdysteroid kinase, myosin heavy chain, and apoptosis inhibitor, were verified by quantitative PCR experiments. One cuticle gene was annotated, and phylogenetic analysis showed that this sequence clustered with the penaeid cuticle genes. This study provides valuable data and a scientific basis for understanding the mechanism of growth differences in M. japonicus at the molecular-genetic level.
On Fuzzy and Crisp Solutions of a Novel Fractional Pandemic Model
Authors: Umapathy Kalpana , Palanivelu Balaganesan , Leiva Víctor , Dhandapani Prasantha Bharathi , Castro Cecilia
Published: July 2023

Understanding disease dynamics is crucial for accurately predicting and effectively managing epidemic outbreaks. Mathematical modeling serves as an essential tool in such understanding. This study introduces an advanced susceptible, infected, recovered, and dead (SIRD) model that uniquely considers the evolution of the death parameter, alongside the susceptibility and infection states. This model accommodates the varying environmental factors influencing disease susceptibility. Moreover, our SIRD model introduces fractional changes in death cases, which adds a novel dimension to the traditional counts of susceptible and infected individuals. Given the model’s complexity, we employ the Laplace-Adomian decomposition method. The method allows us to explore various scenarios, including non-fuzzy non-fractional, non-fuzzy fractional, and fuzzy fractional cases. Our methodology enables us to determine the model’s equilibrium positions, compute the basic reproduction number, confirm stability, and provide computational simulations. Our study offers insightful understanding into the dynamics of pandemic diseases and underscores the critical role that mathematical modeling plays in devising effective public health strategies. The ultimate goal is to improve disease management through precise predictions of disease behavior and spread.
Antibacterial Thermosensitive Silver–Hydrogel Nanocomposite Improves Wound Healing
Authors: Amiri Nafise , Ghaffari Sahand , Hassanpour Ida , Chae Taesik , Jalili Reza , Kilani Ruhangiz Taghi , Ko Frank , Ghahary Aziz , Lange Dirk
Published: July 2023

Bacterial infection and poor cell recruitment are among the main factors that prolong wound healing. To address this, a strategy is required that can prevent infection while promoting tissue repair. Here, we have created a silver nanoparticle-based hydrogel composite that is antibacterial and provides nutrients for cell growth, while filling cavities of various geometries in wounds that are difficult to reach with other dressings. Silver nanoparticles (AgNPs) were synthesized by chemical reduction and characterized using transmission electron microscopy (TEM), dynamic light scattering (DLS), and inductively coupled plasma-mass spectroscopy (ICP-MS). Using varying concentrations of AgNPs (200, 400, and 600 ppm), several collagen-based silver–hydrogel nanocomposite candidates were generated. The impact of these candidates on wound healing was assessed in a rat splinted wound model, while their ability to prevent wound infection from a contaminated surface was assessed using a rat subcutaneous infection model. Biocompatibility was assessed using the standard MTT assay and in vivo histological analyses. Synthesized AgNPs were spherical and stable, and while hydrogel alone did not have any antibacterial effect, AgNP–hydrogel composites showed significant antibacterial activity both in vitro and in vivo. Wound healing was found to be accelerated with AgNP–hydrogel composite treatment, and no negative effects were observed compared to the control group. The formulations were non-cytotoxic and did not differ significantly in hematological and biochemical factors from the control group in the in vivo study. By presenting promising antibacterial and wound healing activities, silver–hydrogel nanocomposite offers a safe therapeutic option that can be used as a functional scaffold for an acceleration of wound healing.
Determination of Dynamic Properties of Fine-Grained Soils at High Cyclic Strains
Authors: Shah Syed Samran Ali , Asif Abdul Rahim , Ahmed Waqas , Islam Ihtisham , Waseem Muhammad , Janjuhah Hammad Tariq , Kontakiotis George
Published: July 2023

Shear modulus (SM) and damping ratio (DR) are significant in seismic design and the performance of geotechnical systems. The evaluation of soil reactions to dynamic loads, such as earthquakes, blasts, train, and traffic vibrations, necessitates the estimation of dynamic SM and DR. The aim of this research is to determine the cyclic parameters of unsaturated soils in and around Peshawar, and how these properties depend upon the varied confining pressures and shear strains. Undisturbed samples were collected using Shelby tubes from five boreholes at different locations along Jamrud Road, Peshawar. The index properties (grain size distribution, plasticity index, and specific gravity) and dynamic properties of these samples were determined. Three samples of 100 mm in height and 50 mm in diameter were obtained from each Shelby tube. After preparing and mounting the sample in the triaxial cell, the sample is first saturated by increasing the cell and back pressures in increments of 50 kPa until the value of Skempton’s pore pressure parameter (B) reaches ≥ 0.96. Samples were consolidated at confining pressures of 150, 200, and 300 kPa, then subjected to cyclic shear strains of 0.2, 1, 2, 2.5, and 5%. Shear stress–strain hysteresis loops were plotted, and the values of SM and DR were calculated for each cycle. Generally, at shear strains of 0.2 and 1%, the slope of the loops is steep, and gradually becomes gentler at higher strains of 2, 2.5, and 5%. It is found that, with an increasing number of cycles, the SM and DR decrease. The SM decreases with increasing shear strain, whereas the DR increases at shear strains of 0.2–1%, then decreases for strains of 2, 2.5, and 5%. The confining pressure has more influence at a shear strain of 0.2–1%, while little effect has been observed at a shear strain of 2.2–5%. The values of SM are higher at higher confining pressures at a given shear strain. The results show higher stress values during the initial cycles because of the greater effective stress that developed in response to shear strain while, with an increase in the number of cycles, the pore water pressure gradually increases, thereby reducing the effective stress and weakening the bonds between soil particles. In dynamics, when the confining pressure increases, particles are closer to contact, so the travel paths of waves increase. The energy loss will increase, so DR will decrease.
Facilitating Access to Current, Evidence-Based Health Information for Non-English Speakers
Authors: Pelicioni Paulo Henrique Silva , Michell Antonio , Santos Paulo Cezar Rocha dos , Schulz Jennifer Sarah
Published: July 2023

Scientific communication is crucial for the development of societies and the advancement of knowledge. However, many countries, and, consequently, their researchers, clinicians and community members, lack access to this information due to the information being disseminated in English rather than their native language. In this viewpoint, we aim to discuss the impacts of this problem and also outline recommendations for facilitating non-English speakers’ access to current, evidence-based health information, thus extending the impact of science beyond academia. First, the authors discuss the barriers to accessing scientific health information for non-English speakers and highlight the negative impact of imposing English as a predominant language in academia. Next, the authors discuss the impacts of reduced access to clinical information for non-English speakers and how this reduced access impacts clinicians, clients, and health systems. Finally, the authors provide recommendations for enhancing access to scientific communication worldwide.
Hearing Loss and Blood Coagulation Disorders: A Review
Authors: Corazzi Virginia , Migliorelli Andrea , Bianchini Chiara , Pelucchi Stefano , Ciorba Andrea
Published: July 2023

A relationship between microvascular disorders and sensorineural hearing loss (SNHL) has been widely proposed. The vascular hypothesis, theorized for the onset of sudden SNHL (SSNHL), is among the most acknowledged: a localized acute cochlear damage, of ischemic or haemorrhagic nature, could be considered a causative factor of SSNHL. The aim of this review is to assess (i) the effect on hearing in patients affected by blood coagulation disorders (prothrombotic or haemorrhagic) and (ii) the possible etiopathogenetic mechanisms of the related hearing loss. A PRISMA-compliant review was performed. Medline, Embase, and Cinahl databases were searched from inception to 31 January 2023, and a total of 14 studies have been included in the review. The available data suggest that it is possible to consider clotting disorders as a potential condition at risk for sensorineural hearing loss; in particular, coagulation tests and eventually the assessment of genetic and acquired prothrombotic factors should be recommended in patients with SSNHL. Also, an audiological evaluation should be recommended for patients with blood coagulation disorders presenting cochlear symptoms, especially in those suffering from clotting diseases.
Host–Bacterium Interaction Mechanisms in Staphylococcus aureus Endocarditis: A Systematic Review
Authors: Nappi Francesco , Avtaar Singh Sanjeet Singh
Published: July 2023

Staphylococci sp. are the most commonly associated pathogens in infective endocarditis, especially within high-income nations. This along with the increasing burden of healthcare, aging populations, and the protracted infection courses, contribute to a significant challenge for healthcare systems. A systematic review was conducted using relevant search criteria from PubMed, Ovid’s version of MEDLINE, and EMBASE, and data were tabulated from randomized controlled trials (RCT), observational cohort studies, meta-analysis, and basic research articles. The review was registered with the OSF register of systematic reviews and followed the PRISMA reporting guidelines. Thirty-five studies met the inclusion criteria and were included in the final systematic review. The role of Staphylococcus aureus and its interaction with the protective shield and host protection functions was identified and highlighted in several studies. The interaction between infective endocarditis pathogens, vascular endothelium, and blood constituents was also explored, giving rise to the potential use of antiplatelets as preventative and/or curative agents. Several factors allow Staphylococcus aureus infections to proliferate within the host with numerous promoting and perpetuating agents. The complex interaction with the hosts’ innate immunity also potentiates its virulence. The goal of this study is to attain a better understanding on the molecular pathways involved in infective endocarditis supported by S. aureus and whether therapeutic avenues for the prevention and treatment of IE can be obtained. The use of antibiotic-treated allogeneic tissues have marked antibacterial action, thereby becoming the ideal substitute in native and prosthetic valvular infections. However, the development of effective vaccines against S. aureus still requires in-depth studies.
Opioids Alleviate Oxidative Stress via the Nrf2/HO-1 Pathway in LPS-Stimulated Microglia
Authors: Shivling Mali Akash , Honc Ondrej , Hejnova Lucie , Novotny Jiri
Published: July 2023

Opioids are known to have antioxidant effects and to modulate microglial function under certain conditions. It has been previously shown that opioid ligands can effectively inhibit the release of proinflammatory cytokines when stimulated with lipopolysaccharide (LPS) and convert microglia to an anti-inflammatory polarization state. Here, we used C8-B4 cells, the mouse microglial cell line activated by LPS as a model to investigate the anti-inflammatory/antioxidant potential of selected opioid receptor agonists (DAMGO, DADLE, and U-50488). We found that all of these ligands could exert cytoprotective effects through the mechanism affecting LPS-induced ROS production, NADPH synthesis, and glucose uptake. Interestingly, opioids elevated the level of reduced glutathione, increased ATP content, and enhanced mitochondrial respiration in microglial cells exposed to LPS. These beneficial effects were associated with the upregulation of the Nrf2/HO-1 pathway. The present results indicate that activation of opioid signaling supports the preservation of mitochondrial function with concomitant elimination of ROS in microglia and suggest that an Nrf2/HO-1 signaling pathway-dependent mechanism is involved in the antioxidant efficacy of opioids. Opioid receptor agonists may therefore be considered as agents to suppress oxidative stress and inflammatory responses of microglia.
FOXS-GSC—Fast Offset Xpath Service with HexagonS Communication
Authors: Brennand Celso A. R. L. , Meneguette Rodolfo , Filho Geraldo P. Rocha
Published: July 2023

Congestion in large cities is widely recognized as a problem that impacts various aspects of society, including the economy and public health. To support the urban traffic system and to mitigate traffic congestion and the damage it causes, in this article we propose an assistant Intelligent Transport Systems (ITS) service for traffic management in Vehicular Networks (VANET), which we name FOXS-GSC, for Fast Offset Xpath Service with hexaGonS Communication. FOXS-GSC uses a VANET communication and fog computing paradigm to detect and recommend an alternative vehicle route to avoid traffic jams. Unlike the previous solutions in the literature, the proposed service offers a versatile approach in which traffic road classification and route suggestions can be made by infrastructure or by the vehicle itself without compromising the quality of the route service. To achieve this, the service operates in a decentralized way, and the components of the service (vehicles/infrastructure) exchange messages containing vehicle information and regional traffic information. For communication, the proposed approach uses a new dedicated multi-hop protocol that has been specifically designed based on the characteristics and requirements of a vehicle routing service. Therefore, by adapting to the inherent characteristics of a vehicle routing service, such as the density of regions, the proposed communication protocol both enhances reliability and improves the overall efficiency of the vehicle routing service. Simulation results comparing FOXS-GSC with baseline solutions and other proposals from the literature demonstrate its significant impact, reducing network congestion by up to 95% while maintaining a coverage of 97% across various scenery characteristics. Concerning road traffic efficiency, the traffic quality is increasing by 29%, for a reduction in carbon emissions of 10%.
Clinical Outcome of Kidney Transplant Recipients with C1q-Binding De Novo Donor Specific Antibodies: A Single-Center Experience
Authors: Marinaki Smaragdi , Vittoraki Angeliki , Tsiakas Stathis , Kofotolios Ioannis , Darema Maria , Ioannou Sofia , Vallianou Kalliopi , Boletis John
Published: July 2023

Complement activation by HLA antibodies is a key component of immune-mediated graft injury. We examined the clinical outcomes of kidney transplant recipients with complement-fixing de novo donor-specific antibodies (dnDSA) who were followed in our center. The C1q-binding ability was retrospectively assessed in 69 patients with dnDSA and mean fluorescence intensity (MFI) values > 2000 out of the 1325 kidney transplant recipients who were screened for DSA between 2015 and 2019. Luminex IgG single antigen beads (SAB)and C1q-SAB assays (One Lambda) were used. C1q-binding dnDSA was identified in 32/69 (46.4%) of the patients. Significantly higher MFI values were observed in C1q-positive DSA (18,978 versus 5840, p < 0.001). Renal graft biopsies were performed in 43 of the kidney transplant recipients (62.3%) with allograft dysfunction. Antibody-mediated rejection (ABMR) was detected in 29/43 (67.4%) of the patients. The incidence of ABMR was similar among patients with C1q-binding and non-C1q-binding DSA (51.7% vs. 48.3%, p = 0.523). Graft loss occurred in 30/69 (43.5%) of the patients at a median time of 82.5 months (IQR 45–135) from DSA detection. C1q-binding DSA was present in more patients who experienced graft loss (53.1% vs. 35.1%, p = 0.152). Higher MFI values and inferior clinical outcomes occurred in most of the kidney transplant recipients with C1q-binding dnDSA.
Current Status of and Future Developments in Acute Stroke Management
Authors: Ntoulias Nikolaos , Brehm Alex , Psychogios Marios-Nikos
Published: July 2023

Stroke treatment has advanced rapidly over the last few years [...]
Appropriate Implantable Cardioverter-Defibrillator Therapy in Patients with Ventricular Arrhythmia of Unclear Cause in Secondary Prevention of Sudden Cardiac Death
Authors: Noordman Alwin B. P. , Rienstra Michiel , Blaauw Yuri , Mulder Bart A. , Maass Alexander H.
Published: July 2023

In this study, we sought to investigate the occurrence of appropriate implantable cardioverter-defibrillator (ICD) therapies and inappropriate shocks in secondary prevention ICD recipients with ventricular arrhythmia of unclear cause and ventricular arrhythmia in the context of underlying heart disease. In this retrospective study, consecutive patients with an ICD implanted for secondary prevention in the University Medical Center Groningen (UMCG), the Netherlands between 1 January 2012 and 31 December 2018 were included. Patients were classified as having ventricular arrhythmia of unclear cause if no clear cause was found which could explain the index ventricular arrhythmia. The primary outcome was appropriate ICD therapy. The study population consisted of 257 patients. In 220 patients, an underlying heart disease could be identified as the cause of ventricular arrhythmia, while 37 patients had an unclear cause of ventricular arrhythmia. The median age was 64 years (interquartile range (IQR) 53–72 years). Forty-five (18%) patients were women. During a median duration of follow-up of 6.2 years (IQR 4.8–7.8 years), appropriate ICD therapy occurred in 95 (37%) patients. This number was 90 (41%) in the group with a clear etiology and 5 (14%) in the group with an unclear etiology. In multivariable analysis, index ventricular arrhythmia of unclear cause was associated with fewer appropriate ICD therapies (HR 0.37 [95% CI 0.14–0.99]; p = 0.048), as well as an increased risk of inappropriate ICD shocks (HR 3.71 [95% CI 1.17–11.80]; p = 0.026). Index ventricular arrhythmia of unclear cause was significantly associated with fewer appropriate ICD therapies.
Biomarkers Associated with Thrombosis in Patients with Peripherally Inserted Central Catheter: A Systematic Review and Meta-Analysis
Authors: Cardoso Patrícia Cristina , Rabelo-Silva Eneida Rejane , Martins Bock Patricia , Chopra Vineet , Saffi Marco Aurélio Lumertz
Published: July 2023

Background: The measurement and identification of plasma biomarkers can support the estimation of risk and diagnosis of deep vein thrombosis (DVT) associated with the use of a peripherally inserted central catheter (PICC). Objectives: This systematic review and meta-analysis aimed to identify the association between the levels of potential biomarkers that reflect the activation of the blood system, long-term vascular complications, inflammatory system, and the occurrence of PICC-related DVT. Methods: Seven electronic databases (Embase, Web of Science, Medline, Scopus, Cinahl, Cochrane Central Register of Controlled Trials, and ERIC) were searched to identify literature published until December 2022. Studies were required to report: (I) adult and pediatric patients, outpatient or admitted to clinical, surgical, or ICU with PICC; (II) patients with PICC-related DVT and patients without PICC-related DVT as a comparator; and (III) at least one biomarker available. The Newcastle–Ottawa Scale was used to evaluate the quality of the studies. Study precision was evaluated by using a funnel plot for platelets level. We provided a narrative synthesis and meta-analysis of the findings on the biomarkers’ outcomes of the studies. We pooled the results using random effects meta-analysis. The meta-analysis was conducted using Review Manager software v5.4. This systematic review is registered in PROSPERO (CRD42018108871). Results: Of the 3564 studies identified (after duplication removal), 28 were included. PICC-related DVT was associated with higher D-dimers (0.37 μg/mL, 95% CI 0.02, 0.72; p = 0.04, I2 = 92%; p for heterogeneity < 0.00001) and with higher platelets (8.76 × 109/L, 95% CI 1.62, 15.91; p = 0.02, I2 = 41%; p for heterogeneity = 0.06). Conclusions: High levels of D-dimer and platelet were associated with DVT in patients with PICC. However, biomarkers such as APTT, fibrinogen, FDP, glucose, hemoglobin, glycated hemoglobin, INR, prothrombin time, prothrombin fragment 1.2, the thrombin–antithrombin complex, and WBC were not related to the development of DVT associated with PICC.
Clinical Application of the HCM-AF Risk Score in the Prediction of Clinical Outcomes of Polish Patients with Hypertrophic Cardiomyopathy
Authors: Stec Maria , Suleja Agata , Gondko Daniel , Kuczmik Wiktoria , Roman Jakub , Dziadosz Dominika , Szydło Krzysztof , Mizia-Stec Katarzyna
Published: July 2023

The recently introduced HCM-AF Risk Calculator allows the prognosis of atrial fibrillation (AF) occurrence in hypertrophic cardiomyopathy (HCM) patients. The aim of this study was to assess the clinical application of the HCM-AF Risk Score in the prediction of the clinical outcomes of Polish patients. The study included 92 patients (50.0% female, median age 55 years), with a baseline sinus rhythm diagnosed between 2013 and 2018. The analysis involved the incidence of clinical characteristics and outcomes, total mortality, rehospitalisation, and the course of heart failure (HF). According to the HCM-AF Risk Score, the HCM population was stratified into three subgroups, with a low (13/14.2%), intermediate (30/32.6%), and high risk of AF (49/53.2%). Subgroups differed significantly: the high-risk subgroup was older, had a higher body mass index (BMI), and more advanced signs of left ventricular (LV) hypertrophy and left atrium (LA) dilatation. The registered AF incidence was 31.5% and 43.5% in the 2- and 5-year follow-ups, and it was significantly higher than in the HCM-AF Risk Score population, which had 4.6% in the 2-year follow-up, and 10.7% in the 5-year follow-up. In the whole population, the AF incidence in both the 2- and 5-year follow-ups revealed a strong correlation with the HCM-AF Risk Score (r = 0.442, p < 0.001; r = 0.346, p < 0.001, respectively). The clinical outcomes differed among the subgroups: the total mortality was 15.4% vs. 20.0% vs. 42.9% (p < 0.05); rehospitalisation was 23.1% vs. 53.3% vs. 71.4% (p < 0.05). The highest HF progression was in the high-risk subgroup (36.7%). Regardless of the high results of the HCM-Risk Score in Polish patients, the score underestimates the real-life high level of AF incidence. The HCM-AF Risk Score seems to be useful in the prediction of the general clinical outcomes in HCM patients.
Time-Dependent Changes of Klotho and FGF-23 Levels after Kidney Transplantation: Role of Cold Ischemia Time, Renal Function and Graft Inflammation
Authors: Vazquez-Sanchez Teresa , Sanchez-Niño Maria Dolores , Ruiz-Esteban Pedro , López Veronica , León Myriam , Caballero Abelardo , Ruiz-Escalera Juan Francisco , Ortiz Alberto , Torres Armando , Rodriguez Mariano , Hernandez Domingo
Published: July 2023

We investigated the evolution of serum klotho (s-Kl) and FGF-23 during the first two years post-kidney transplantation (KT), considering the cold ischemia time (CIT), glomerular filtration rate (GFR) and graft subclinical inflammation (SCI). We undertook a prospective, cohort, multicenter study of consecutive patients between April 2018 and January 2021 (with follow-up at 24 months). Subgroups were analyzed according to the median CIT (<14 vs. ≥14 h), the median GFR (≤40 vs. >40 mL/min/1.73 m2) and the presence of SCI at month 3. A total of 147 patients were included. s-Kl and fibroblast growth factor-23 (FGF-23) levels were measured at baseline and at months 3, 12 and 24. Graft biopsies (n = 96) were performed at month 3. All patients had low s-Kl levels at month 3. Patients with CIT < 14 h exhibited a significant increase in s-Kl at month 24. In patients with CIT ≥ 14 h, s-Kl at month 3 fell and lower s-Kl levels were seen at month 24. Patients with a GFR > 40 had a lesser decrease in s-Kl at month 3. FGF-23 fell significantly at months 3 and 12 in both GFR groups, a reduction maintained during follow-up. There were significant inter-group differences in s-Kl from months 3 to 24. CIT, GFR at 3 months and SCI were significantly associated with s-KI at month 3. A reduction in s-Kl at month 3 post-KT could be explained by longer CIT and delayed graft function as well as by impaired graft function. Early SCI may regulate s-Kl increase post-KT.
Frequency and Time Domain Analysis of EEG Based Auditory Evoked Potentials to Detect Binaural Hearing in Noise
Authors: Ignatious Eva , Azam Sami , Jonkman Mirjam , De Boer Friso
Published: July 2023

Hearing loss is a prevalent health issue that affects individuals worldwide. Binaural hearing refers to the ability to integrate information received simultaneously from both ears, allowing individuals to identify, locate, and separate sound sources. Auditory evoked potentials (AEPs) refer to the electrical responses that are generated within any part of the auditory system in response to auditory stimuli presented externally. Electroencephalography (EEG) is a non-invasive technology used for the monitoring of AEPs. This research aims to investigate the use of audiometric EEGs as an objective method to detect specific features of binaural hearing with frequency and time domain analysis techniques. Thirty-five subjects with normal hearing and a mean age of 27.35 participated in the research. The stimuli used in the current study were designed to investigate the impact of binaural phase shifts of the auditory stimuli in the presence of noise. The frequency domain and time domain analyses provided statistically significant and promising novel findings. The study utilized Blackman windowed 18 ms and 48 ms pure tones as stimuli, embedded in noise maskers, of frequencies 125 Hz, 250 Hz, 500 Hz, 750 Hz, 1000 Hz in homophasic (the same phase in both ears) and antiphasic (180-degree phase difference between the two ears) conditions. The study focuses on the effect of phase reversal of auditory stimuli in noise of the middle latency response (MLR) and late latency response (LLR) regions of the AEPs. The frequency domain analysis revealed a significant difference in the frequency bands of 20 to 25 Hz and 25 to 30 Hz when elicited by antiphasic and homophasic stimuli of 500 Hz for MLRs and 500 Hz and 250 Hz for LLRs. The time domain analysis identified the Na peak of the MLR for 500 Hz, the N1 peak of the LLR for 500 Hz stimuli and the P300 peak of the LLR for 250 Hz as significant potential markers in detecting binaural processing in the brain.
Risk Stratification for Herpes Simplex Virus Pneumonia Using Elastic Net Penalized Cox Proportional Hazard Algorithm with Enhanced Explainability
Authors: Wang Yu-Chiang , Lin Wan-Ying , Tseng Yi-Ju , Fu Yiwen , Li Weijia , Huang Yu-Chen , Wang Hsin-Yao
Published: July 2023

Herpes simplex virus (HSV) pneumonia is a serious and often fatal respiratory tract infection that occurs in immunocompromised individuals. The early detection of accurate risk stratification is essential in identifying patients who are at high risk of mortality and may benefit from more aggressive treatment. In this study, we developed and validated a risk stratification model for HSV bronchopneumonia using an elastic net penalized Cox proportional hazard algorithm. We analyzed data from a cohort of 104 critically ill patients with HSV bronchopneumonia identified in Chang Gung Memorial Hospital, Linkou, Taiwan: one of the largest tertiary medical centers in the world. A total of 109 predictors, both clinical and laboratory, were identified in this process to develop a risk stratification model that could accurately predict mortality in patients with HSV bronchopneumonia. This model was able to differentiate the risk of death and predict mortality in patients with HSV bronchopneumonia compared to the APACHE II score in the early stage of ICU admissions. Both hazard ratio coefficient and selection frequency were used as the metrics to enhance the explainability of the informative predictors. Our findings suggest that the elastic net penalized Cox proportional hazard algorithm is a promising tool for risk stratification in patients with HSV bronchopneumonia and could be useful in identifying those at high risk of mortality.
Testing the Reciprocal Effect between Value of Education, Time Investment, and Academic Achievement in a Large Non-Western Sample
Authors: Liu Meimei , Vu TuongVan , van Atteveldt Nienke , Meeter Martijn
Published: July 2023

Many theories of motivation suggest that motivation and academic achievement reinforce each other over time, yet few longitudinal studies have examined behavioral pathways that may mediate interplay from motivation to achievement. Moreover, empirical studies so far have mostly focused on Western countries. In this study, we first examined whether students’ value of education, as a measure of motivation, is reciprocally related to achievement (class rank and self-rated performance) in a sample of junior high schoolers in an East-Asian country (N = 3445, Korean Youth Panel Study). We tested this reciprocity using different statistical models. Second, we investigated whether the relation between motivation and achievement was mediated by time invested in learning. Reciprocal effects between value of education and academic achievement were found in classic cross-lagged panel models, but only unilateral effects (from achievement to value of education) were found when we used random-intercept and random-curve cross-lagged panel models. Adding the time investment variable, a reciprocal effect between value of education, time investment, and academic achievement was not found with the random-intercept model. In conclusion, the reciprocity between of motivation and achievement are more elusive than previous research suggested; further studies should be dedicated to scrutinizing its existence with various statistical models.
Ship Collision Risk Assessment
Authors: Kim Sang Jin
Published: July 2023

Ship collision accidents are one of the most frequent events, and cause serious damages to health, structural safety and the environment [...]
Deep-Water Dynamics along the 2012–2020 Observations on the Continental Margin of the Southern Adriatic Sea (Mediterranean Sea)
Authors: Paladini de Mendoza Francesco , Schroeder Katrin , Langone Leonardo , Chiggiato Jacopo , Borghini Mireno , Giordano Patrizia , Miserocchi Stefano
Published: July 2023

This work presents the results of long-term deep-water observations carried out in the southwestern Adriatic margin. Hydrodynamics and thermohaline measurements were carried out in the last 100 m of the water column using two long-term moorings placed at two different locations along the western sector of the Adriatic continental margin (open slope vs. submarine canyon). The observations, carried out over a period of almost 10 years, made it possible to define the intra- and interannual deep-water dynamics, which are mainly influenced by the passage of cold, dense water. The hydrodynamic field is influenced by seasonal behavior and varies from year to year, with no clear temporal trend or periodicity. Thermohaline properties follow hydrodynamics but also show a climatological trend toward higher temperatures and salinity. The combination and variability of preconditioning factors explains the interannual variability in dense water passage at the mooring sites triggering the formation of dense water in the northern Adriatic. The impulsive nature of the dense water flow, which is difficult to capture with sporadic oceanographic surveys, and its linkage with the large-scale atmospheric circulation make continuous monitoring essential to answer open questions about cascading processes and deep-water dynamics under a global change scenario.
Strata Fee Management in Condominiums via Smart Contracts
Authors: Scholte Liam , Wang Rui , Chung Kwok Keung , Aibin Michal
Published: July 2023

Condominiums and similar properties use a stratum to manage daily operations, and owners fund it through strata fees. While existing strata fee management systems may be able to handle such funds, such systems could be more inherently transparent. It is possible to leverage the digital ledger from blockchain networks and smart contracts to build a fully transparent strata fee management system. This paper proposes designing a strata fee management system based on a smart contract in the Ethereum network. Both strata corporations and homeowners can interact with the smart contract to execute common procedures such as paying strata fees and handling expenses. Using smart contracts for strata fee management, it is believed that the chance of fraud by strata corporations is lowered compared to other systems.