bluuebunny/crossref_metadata_2025 huggingface dataset:
Surgical site infection following cesarean section and its predictors in Ethiopia: A systematic review and meta-analysis
Authors: Lake Eyob Shitie , Alamrew Abebaw , Belay Wagaye Shumete , Yilak Gizachew , Berihun Erega Besfat , Abita Zinie , Ayele Mulat
Published: March 2024

Introduction

Worldwide, surgery related deaths within 30 days of the procedure accounts the third contributor among all causes of deaths, with an estimated 4.2 million people annually and half of these deaths occur in low and middle income countries.

Objective

To determine the pooled prevalence of surgical site infection following cesarean section and its predictors in Ethiopia.

Methods

A systematic review and meta-analysis were conducted by using PRISMA guideline. An appropriate and comprehensive search of PubMed, MEDLINE, EMBASE, CINAHL, Google Scholar, HINARI and Scopus was done. This SRMA included all articles conducted in all regional state of Ethiopia reporting the prevalence/proportion/incidence of SSI after cesarean section and/or associated factors. All observational study designs were included in this SRMA. Articles which lack our outcome of interest: SSI following cesarean section and its predictors were excluded from this SRMA. The I2 statistic was used to quantify heterogeneity across studies. Funnel plot asymmetry and Egger’s tests were used to check for publication bias. A random effect model was used to estimate the pooled prevalence of SSI. Adjusted Odds Ratio (OR) with 95% Confidence Interval (CI) was also considered to determine the association of identified variables with SSI. Statistical analysis was conducted using STATA version 17 software.

Result

Initially 6334 studies were identified and finally 19 studies were found eligible for the analysis. Studies with a score of 7 and above were included for the final systematic review and meta-analysis. The review was comprised of 14 cross sectional studies, 4 cohort and one case control studies. The pooled estimate of SSI in Ethiopia was 11.13% (95%CI, 9.29–12.97%). Prolonged labor (AOR = 3.16, 95% CI; (2.14–4.68)), chorioamnionitis (AOR = 4.26, 95% CI; (1.99–8.91)), prolonged PROM (AOR = 3.80, 95% CI; (2.51–5.62)), repeated vaginal examination (AOR = 3.80, 95% CI; (2.45–5.88)), decreased hemoglobin level (AOR = 4.57, 95%CI; (3.16–6.60)), vertical skin incision (AOR = 3.09, 95% CI; (2.04–4.67)) and general anesthesia (AOR = 1.82, 95% CI (1.21–2.75)) are significantly associated with SSI after cesarean section in Ethiopia.

Conclusion

SSI after cesarean section in Ethiopia is high. Prolonged labor, chorioamnionits, prolonged PROM, repeated vaginal examination, decreased Hgb level, vertical skin incision and general anesthesia were positively associated. Thus, evidence based intra-partum care should be practiced.
The development, feasibility and credibility of intra-abdominal pressure measurement techniques: A scoping review
Authors: Li ZhiRu , Wang HuaFen , Lu FangYan
Published: March 2024

Aim

To provide a comprehensive overview on emerging direct and alternative methods for intra-abdominal pressure (IAP) measurement techniques.

Methods

This was a scoping review study following Arksey and Malley’s framework. The PubMed, EMBASE, Web of Science, EBSCO, Scopus and ProQuest databases were searched, and we only considered studies published from 2000 as we have extended the data from two previous reviews. Original studies that reported on the development, feasibility and credibility of IAP measurement techniques were included.

Results

Forty-two of 9954 screened articles were included. IAP measurement techniques include three major categories: direct, indirect and less invasive measurement techniques. Agreement analyses were performed in most studies, and some explored the safety, time expenditure and reproducibility of IAP measurement techniques.

Conclusions

Clinical data assessing the validation of new IAP measurement techniques or the reliability of established measurement techniques remain lacking. Considering the cost and invasiveness, direct measurement is not recommended as a routine method for IAP measurement and should be preserved for critically ill patients where standard techniques are contraindicated or could be inaccurate. The measurement accuracy, reliability and sensitivity of the transrectal and transfemoral vein methods remain insufficient and cannot be recommended as surrogate IAP measures. Transvesical measurement is the most widely used method, which is the potentially most easy applicable technique and can be used as a reliable method for continuous and intermittent IAP measurement. Wireless transvaginal method facilitates the quantitative IAP measurement during exercise and activity, which laying the foundations for monitoring IAP outside of the clinic environment, but the accuracy of this technique in measuring absolute IAP cannot be determined at present. Less invasive technology will become a new trend to measure IAP and has substantial potential to replace traditional IAP measurement technologies, but further validation and standardization are still needed. Medical professionals should choose appropriate measurement tools based on the advantages and disadvantages of each IAP technique in combination with assessing specific clinical situations.
Natural disasters, livelihood, and healthcare challenges of the people of a riverine island in Bangladesh: A mixed-method exploration
Authors: Hossain Ahmed , Chowdhury Anika Tasneem , Mahbub Masum , Khan Mahmuda , Rahman Taifur , Sharif Azaz Bin , Hijazi Heba , Alameddine Mohamad
Published: March 2024

Background

Bangladesh’s islands, because of their geographical location, frequently encounter crises like floods and river erosion, which pose significant threats to the residents’ well-being and livelihoods. To delve into the effects of these disasters on livelihood and healthcare challenges, a mixed-method study was undertaken in a riverine-island near a major river of Bangladesh.

Methodology

Between February 15th and February 28th, 2023, a cross-sectional study was conducted on an island in Bangladesh. The quantitative method involved conducting a survey of 442 households, with a total of 2921 participants. Additionally, 10 in-depth interviews and 10 key-informant interviews were conducted using semi-structured guidelines. Qualitative interviews were audio-recorded, transcribed verbatim, and analyzed using a thematic analysis. Triangulation was employed in this study through the integration of qualitative and quantitative analysis, resulting in the presentation of findings that offer an in-depth comprehension of the phenomenon being investigated.

Results

River erosions and floods are common and recurring natural disasters that significantly impact the lives of the riverine island inhabitants. These disasters often disrupted their livelihoods, forced many residents to endure substandard living conditions or relocated during flood events. The island faced a low diagnostic prevalence of chronic diseases (e.g., 5.1% of adults were hypertension and 2.5% are diabetes) because of the absence of diagnostic facilities and a shortage of certified doctors. A significant number of chronic illness people in the community turned to alternative medicine sources (39.3%) such as homeopathy, Kabiraj, and Ayurvedic medicine, especially it gets increased during periods of natural disasters. Moreover, reproductive aged women revealed that 79.4% of them gave birth at home, with 6.0% of these home deliveries resulting in miscarriage or infant death. The destruction of crops, unstable job opportunities, an inadequate educational system, and a deficient healthcare delivery system exacerbated the hardships faced by the population affected by these disasters.

Conclusion

The failure to seek treatment for chronic diseases and undiagnosed diseases is a significant health issue among the aging adults on the island. Island residents face the challenge of establishing effective prevention strategies for the well-being of older adults especially at the period of natural disasters. It is crucial for the government and non-governmental organizations (NGOs) to collaborate to prevent the negative effects of floods and river erosions. This should include efforts to enhance the quality of education, healthcare services, job opportunities, and financial assistance for rebuilding homes.
Effects of paternal arachidonic acid supplementation on offspring behavior and hypothalamus inflammation markers in the mouse
Authors: Vázquez-Sánchez Atenea , Rodríguez-Ríos Dalia , Colín-Castelán Dannia , Molina-Torres Jorge , Ramírez-Chávez Enrique , Romo-Morales Gloria del Carmen , Zaina Silvio , Lund Gertrud
Published: March 2024

Arachidonic acid (AA) is involved in inflammation and plays a role in growth and brain development in infants. We previously showed that exposure of mouse sires to AA for three consecutive generations induces a cumulative change in fatty acid (FA) involved in inflammation and an increase in body and liver weight in the offspring. Here, we tested the hypothesis that paternal AA exposure changes the progeny’s behavioral response to a proinflammatory insult, and asked whether tissue-specific FA are associated with that response. Male BALB/c mice were supplemented daily with three doses of AA for 10 days and crossed to non-supplemented females (n = 3/dose). Two-month-old unsupplemented male and female offspring (n = 6/paternal AA dose) were exposed to Gram-negative bacteria-derived lipopolysaccharides (LPS) or saline control two hours prior to open field test (OFT) behavioral analysis and subsequent sacrifice. We probed for significant effects of paternal AA exposure on: OFT behaviors; individual FA content of blood, hypothalamus and hypothalamus-free brain; hypothalamic expression profile of genes related to inflammation (Tnfa, Il1b, Cox1, Cox2) and FA synthesis (Scd1, Elovl6). All parameters were affected by paternal AA supplementation in a sex-specific manner. Paternal AA primed the progeny for behavior associated with increased anxiety, with a marked sex dimorphism: high AA doses acted as surrogate of LPS in males, realigning a number of OFT behaviors that in females were differential between saline and LPS groups. Progeny hypothalamic Scd1, a FA metabolism enzyme with documented pro-inflammatory activity, showed a similar pattern of differential expression between saline and LPS groups at high paternal AA dose in females, that was blunted in males. Progeny FA generally were not affected by LPS, but displayed non-linear associations with paternal AA doses. In conclusion, we document that paternal exposure to AA exerts long-term behavioral and biochemical effects in the progeny in a sex-specific manner.
Prevalence of unqualified sources of antimalarial drug prescription for children under the age of five: A study in 19 low- and middle-income countries
Authors: Hossain Md Sabbir , Ahmed Talha Sheikh , Haque Mohammad Anamul , Chowdhury Muhammad Abdul Baker , Uddin Md Jamal
Published: March 2024

Background

Antimalarial drug resistance poses a severe danger to global health. In Low- and Middle-Income Countries (LMICs), there is a lack of reliable information on antimalarial prescriptions for recent malarial fever in children under five. Our study aims to determine the prevalence of unqualified sources of antimalarial drug prescription for children under the age of five in 19 low- and middle-income countries.

Methods

We performed a cross-sectional study of the Malaria Indicator Survey (MIS) datasets (n = 106265) across 19 LMICs. The recent MIS datasets were used, and the study only included children under five who had taken an antimalarial drug for a recent malarial fever. The outcome variable was classified into two distinct categories: those who had taken antimalarial drugs for malarial fever from qualified sources and those who did not.

Findings

Among LMICs, we found that 87.1% of children under five received an antimalarial prescription from unqualified sources who had recently experienced malarial fever. In several LMICs (Tanzania, Nigeria, and Ghana), a substantial portion of recent antimalarial prescriptions for malaria was taken from unqualified sources (about 60%). Some LMICs (Guinea (31.8%), Mali (31.3%), Nigeria (20.4%), Kenya (2.6%), and Senegal (2.7%)) had low rates of antimalarial drug consumption even though children under five received a high percentage of antimalarial prescriptions from qualified sources for a recent malarial fever. Living in rural areas, having mothers with higher education, and having parents with more wealth were frequently taken antimalarial from qualified sources for recent malarial fever in children under five across the LMICs.

Interpretation

The study draws attention to the importance of national and local level preventative strategies across the LMICs to restrict antimalarial drug consumption. This is because antimalarial prescriptions from unqualified sources for recent malarial fever in children under five were shockingly high in most LMICs and had high rates of unqualified prescriptions in certain other LMICs.
Comparison of EKFC, Pakistani CKD-EPI and 2021 Race-Free CKD-EPI creatinine equations in South Asian CKD population: A study from Pakistani CKD community cohort
Authors: Safdar Aqsa , Akram Waqas , Khan Mahtab Ahmad , Tahir Danish , Butt Muhammad Hammad
Published: March 2024

Introduction

South Asian individuals possess a high risk of chronic kidney disease. There is a need to study, evaluate, and compare the newly suggested glomerular filtration rate (eGFR) equations for accurate CKD diagnosis, staging, and drug dosing. This study aimed to (1) evaluate the European Kidney Function Consortium (EKFC), Pakistani CKD-EPI, and 2021 Race-Free CKD-EPI creatinine equation in the South Asian population with CKD and (2) to examine the expected implications on both CKD classification as well as End Stage Renal Disease (ESRD) prevalence across these equations in South Asian population.

Methods

We carried out a cross-sectional investigation on 385 participants, a CKD cohort ≥ 18 years, at Allama Iqbal Medical College, Jinnah Hospital, Lahore. Serum creatinine was measured by Jaffe’s method and rGFR was measured by inulin clearance.

Results

Pakistani CKD-EPI has a lower median difference at -1.33 ml/min/1.73m2 elevated precision (IQR) at 2.33 (-2.36, -0.03) and higher P30 value at 89.35% than 2021 CKD-EPI and EKFC equations. The mean difference (ml/min/1.73m2), 95% agreement limits (ml/min/1.73m2) of CKD-EPI PK: -1.18, -6.14, 2021 CKD-EPI: -5.98, -13.24 and EKFC: -5.62, -13.01 (P <0.001). These equations highly correlated to rGFR (P <0.001). An upward re-classification in GFR categories was shown by 2021 CKD-EPI and EKFC compared to the Pakistani CKD-EPI equation. However, there was an exception regarding the G5 category, where an elevated count of 217 (56.36%) was shown for CKD-EPI PK. The prevalence of ESRD was seen in entire age groups and prevailed among females more than in males overall equations.

Conclusions

Pakistani CKD-EPI exhibited outstanding performance, while 2021 CKD-EPI and EKFC demonstrated poor performances and could not show an adequate advantage for both CKD classification and prevalence of ESRD compared to Pakistani CKD-EPI. Therefore, Pakistani CKD-EPI appears optimal for this region and warrants future validation in other South Asian countries. In contrast, suitable measures must be implemented in Pakistani laboratories.
Discovering why people believe disinformation about healthcare
Authors: George Joey F.
Published: March 2024

Disinformation–false information intended to cause harm or for profit–is pervasive. While disinformation exists in several domains, one area with great potential for personal harm from disinformation is healthcare. The amount of disinformation about health issues on social media has grown dramatically over the past several years, particularly in response to the COVID-19 pandemic. The study described in this paper sought to determine the characteristics of multimedia social network posts that lead them to believe and potentially act on healthcare disinformation. The study was conducted in a neuroscience laboratory in early 2022. Twenty-six study participants each viewed a series of 20 either honest or dishonest social media posts, dealing with various aspects of healthcare. They were asked to determine if the posts were true or false and then to provide the reasoning behind their choices. Participant gaze was captured through eye tracking technology and investigated through “area of interest” analysis. This approach has the potential to discover the elements of disinformation that help convince the viewer a given post is true. Participants detected the true nature of the posts they were exposed to 69% of the time. Overall, the source of the post, whether its claims seemed reasonable, and the look and feel of the post were the most important reasons they cited for determining whether it was true or false. Based on the eye tracking data collected, the factors most associated with successfully detecting disinformation were the total number of fixations on key words and the total number of revisits to source information. The findings suggest the outlines of generalizations about why people believe online disinformation, suggesting a basis for the development of mid-range theory.
Canopeo app as image-based phenotyping tool in controlled environment utilizing Arabidopsis mutants
Authors: Hale Gabriella , Yuan Ning , Mendu Lavanya , Ritchie Glen , Mendu Venugopal
Published: March 2024

Canopeo app was developed as a simple, accurate, rapid, and free tool to analyze ground cover fraction (GCF) from red-green-blue (RGB) images and videos captured in the field. With increasing interest in tools for plant phenotyping in controlled environments, the usefulness of Canopeo to identify differences in growth among Arabidopsis thaliana mutants in a controlled environment were explored. A simple imaging system was used to compare Arabidopsis mutants based on the FLAVIN-BINDING, KELCH REPEAT, F-BOX-1 (FKF1) mutation, which has been identified with increased biomass accumulation. Two FKF1 lines such as null expression (fkf1-t) and overexpression (FKF1-OE) lines were used along with wild type (Col-0). Canopeo was used to phenotype plants, based on biomass estimations. Under long-day photoperiod, fkf1-t had increased cellulose biosynthesis, and therefore biomass. Resource partitioning favored seedling vigor and delayed onset of senescence. In contrast, FKF1-OE illustrated a determinative growth habit where plant resources are primarily allocated for seed production. This study demonstrates the use of Canopeo for model plants and highlights its potential for phenotyping broadleaved crops in controlled environments. The value of adapting Canopeo for lab use is those with limited experience and resources have access to phenotyping methodology that is simple, accessible, accurate, and cost-efficient in a controlled environment setting.
Cross-asset momentum and the hybrid fund transmission mechanism in China’s stock and bond markets
Authors: Wang Xiaowei , Wang Rui , Zhang Yichun
Published: March 2024

The allocation of assets across different markets is a crucial element of investment strategy. In this regard, stocks and bonds are two significant assets that form the backbone of multi-asset allocation. Among publicly offered funds (The publicly offered funds in China correspond to the mutual funds in the United States, with different names and details in terms of legal form and sales channels), the stock-bond hybrid fund gives investors a return while minimizing the risk through capital flow between the stock and bond markets. Our research on China’s financial market data from 2006 to 2022 reveals a cross-asset momentum between the stock and bond markets. We find that the momentum in the stock market negatively influences the bond market’s return, while the momentum in the bond market positively influences the stock market’s return. Portfolios that exploit cross-asset momentum have excess returns that other asset pricing factors cannot explain. Our analysis reveals that hybrid funds play an intermediary role in the transmission mechanism of cross-asset momentum. We observe that the more flexible the asset allocation ratio of the fund, the more crucial the intermediary role played by the fund. Hence, encouraging the development of hybrid funds and relaxing restrictions on asset allocation ratios could improve liquidity and pricing efficiency. These findings have significant implications for investors seeking to optimize their asset allocation across different markets and for policymakers seeking to enhance the efficiency of China’s financial market.
Trolox and recombinant Irisin as a potential strategy to prevent neuronal damage induced by random positioning machine exposure in differentiated HT22 cells
Authors: Bonanni Roberto , Cariati Ida , Rinaldi Anna Maria , Marini Mario , D’Arcangelo Giovanna , Tarantino Umberto , Tancredi Virginia
Published: March 2024

Neuronal death could be responsible for the cognitive impairments found in astronauts exposed to spaceflight, highlighting the need to identify potential countermeasures to ensure neuronal health in microgravity conditions. Therefore, differentiated HT22 cells were exposed to simulated microgravity by random positioning machine (RPM) for 48 h, treating them with a single administration of Trolox, recombinant irisin (r-Irisin) or both. Particularly, we investigated cell viability by MTS assay, Trypan Blue staining and western blotting analysis for Akt and B-cell lymphoma 2 (Bcl-2), the intracellular increase of reactive oxygen species (ROS) by fluorescent probe and NADPH oxidase 4 (NOX4) expression, as well as the expression of brain-derived neurotrophic factor (BDNF), a major neurotrophin responsible for neurogenesis and synaptic plasticity. Although both Trolox and r-Irisin manifested a protective effect on neuronal health, the combined treatment produced the best results, with significant improvement in all parameters examined. In conclusion, further studies are needed to evaluate the potential of such combination treatment in counteracting weightlessness-induced neuronal death, as well as to identify other potential strategies to safeguard the health of astronauts exposed to spaceflight.
Energy evolution mechanism of structural surfaces in sandstones with different dips based on the energy principle
Authors: Yu Yongjiang , Song Zhiyuan , Liu Jiaming , Yang Yuntao , Dong Xu
Published: March 2024

A uniaxial compression test was conducted on sandstone specimens at various inclination angles to determine the energy evolution characteristics during deformation and damage. Based on the principle of minimum energy dissipation, an intrinsic model incorporating the damage threshold was developed to investigate the mechanical properties of sandstone at different inclination angles, and the energy damage evolution during deformation and damage. This study indicated that when the inclination angle of the structural surface remained below 40°, sandstone exhibited varying mechanical properties based on different inclination angles. The peak strain was positively correlated with the inclination angle, whereas the compressive strength and modulus of elasticity showed negative correlations. From an energy perspective, the deformation and damage of sandstone under external loading entail processes of energy input, accumulation, and dissipation. Moreover, higher inclination angles of the structural surface resulted in a smaller absorbed peak strain and a reduced proportion of dissipated energy relative to the energy input, thereby affecting the evolution of energy damage throughout the process. As the inclination angle of the structural surface increased, the absorbed total strain at the peak value decreased, whereas the proportion of the dissipated energy increased. Additionally, the damage threshold and critical value of the rock specimens increased with the inclination angle. The critical value, a composite index comprising the peak strain, compressive strength, and elastic modulus, also increased accordingly. These findings can offer a novel perspective for analyzing geological disasters triggered by fissure zones within underground rock formations.
Impact of corporate social responsibility on employee loyalty: Mediating role of person-organization fit and employee trust
Authors: Jin Hebo , Li Xuexiao , Li Guangsen
Published: March 2024

The study explores the impact of employee perceptions of corporate social responsibility (CSR) in improving employee loyalty by examining the direct and indirect role of person-organization fit and employee trust. A convenient sampling technique was employed to collect the data sample. A total of 338 questionnaires were collected at three different China-Pakistan Economic Corridor (CPEC) projects in Pakistan. The SmartPLS-3 was used to test the study hypotheses. The results revealed that CSR positively and significantly influenced employee loyalty. The findings indicated a partial mediating impact of P-O fit and employee trust in the relationship between CSR and employee loyalty. Discussions, implications, limitations, and future research direction are also given.
Prevalence and risk factors of work-related musculoskeletal disorders among shopkeepers in Ethiopia: Evidence from a workplace cross-sectional study
Authors: Tesfaye Amensisa Hailu , Kabito Gebisa Guyasa , Aragaw Fantu Mamo , Mekonnen Tesfaye Hambisa
Published: March 2024

Introduction

Work-related musculoskeletal disorders (WRMSDs) are the leading cause of disability worldwide. Shopkeepers are prone to developing work-related musculoskeletal disorders, but they are largely overlooked in research and policy actions, particularly in developing countries. So far, there is a lack of data on the magnitude and factors influencing work-related musculoskeletal disorders among shopkeepers in Ethiopia. Therefore, the current study aimed to explore the prevalence and risk factors of work-related musculoskeletal disorders among shopkeepers in Gondar City, Ethiopia.

Methods

A workplace-based cross-sectional study was conducted from July to August 2022, in Gondar city, Northwest Ethiopia. A multistage sampling technique was used to select 625 shopkeepers. The data were collected using an interviewer-administered standardized Nordic Musculoskeletal Questionnaire. Analysis was made using Stata version 14. Factors associated with the prevalence of work-related musculoskeletal disorders were identified using the multivariable Poisson regression model. The adjusted prevalence ratio with 95% confidence intervals (CIs) and p-value < 0.05 were applied to establish the significance of associations.

Results

The overall prevalence of work-related musculoskeletal disorders among shopkeepers in the past 12 months was found to be 81.1% (N = 507). The most frequently affected body part was the lower back (46.6%), followed by the upper back (43.8%) and shoulder (35.4%). Being female (p = 0.043), being in the age group of ≥40 years (p = 0.028), being overweight (p = 0.035), experiencing job stress (p = 0.006) and prolonged sitting (p = 0.045) were significant factors for the prevalence of work-related musculoskeletal disorders among shopkeepers.

Conclusion

This study revealed that shopkeepers face an alarmingly high prevalence of work-related musculoskeletal disorders. Female, older, overweight, stressed and shopkeepers who sit in the same position for long periods of time were identified as particularly vulnerable groups. These findings call for the urgent development and implementation of preventive measures, including ergonomic adjustments, education and training programs, stress management techniques and the promotion of physical activity, to protect this vulnerable workforce from the debilitating effects of work-related musculoskeletal disorders and to ensure their long-term health and well-being.
Tabernas e taberneiras: espaços de sociabilidade, de transgressão e de escândalo no Portugal do final do Antigo Regime
Authors: Drumond Braga Isabel , Drumond Braga Paulo
Published: March 2024

A taberna foi sempre espaço de sociabilidade, local de consumo de vinho e de petiscos, mas também de escândalo pois ali se jogava, se discutiam ideias e se aliciavam prostitutas. A documentação dos Feitos findos, guardada no Arquivo Nacional da Torre do Tombo (Lisboa), oferece-nos um retrato da violência física e verbal envolvendo mulheres que exerciam as funções de taberneiras na Lisboa dos finais do Antigo Regime. Se algumas foram prevaricadoras, outras surgem como vítimas. Foram estudados 18 casos situados entre 1805 e 1833.
La noción de escándalo en la España de la Edad Moderna a través de la documentación judicial de los tribunales reales
Authors: De las Heras Santos José Luis
Published: March 2024

El concepto de «escándalo» jugó un papel crucial en la administración de justicia y en el mantenimiento del orden social. El escándalo, entendido más allá del mero desorden público, incluía cualquier acto que desestabilizara la armonía social, atentara contra la moral colectiva o las creencias religiosas. Los delitos sexuales, por ejemplo, no solo se perseguían por el daño individual causado, sino también por su impacto en la sociedad, convirtiéndolos en un asunto de interés público. Este enfoque refleja cómo el escándalo no era meramente una cuestión de conducta personal, sino una preocupación de orden público, afectando la percepción social de la autoridad y la estabilidad social.
Escándalos a orilla del mar: la mujer transgresora en la documentación judicial canaria (s. XVIII)
Authors: Rodríguez Arrocha Belinda
Published: March 2024

El objetivo de este artículo es esclarecer las acciones y circunstancias presentes en los casos de escándalo en el señorío occidental canario del siglo XVIII desde un enfoque histórico-jurídico. Las fuentes primarias examinadas son los expedientes judiciales del Fondo Documental de la Casa Fuerte de Adeje, custodiado en el Archivo del Museo Canario (Las Palmas de Gran Canaria) y que concierne a los enclaves del área tinerfeña de Adeje, las islas de La Gomera y El Hierro. Asimismo, se ha atendido a los postulados jurídicos y doctrinales de los juristas más difundidos en el archipiélago, en cuanto directrices para la administración judicial en la esfera local. Este trabajo incide en la consideración del escándalo como conducta que atentaba contra la normativización sexual establecida y alteraba el orden moral en el vecindario afectado. No en vano, los tratados pragmáticos, como la difundida Política para corregidores, contemplaban la disposición que las autoridades locales debían mostrar hacia la preservación de la tranquilidad en sus jurisdicciones, castigando las conductas deshonestas y notorias en la vecindad. En este sentido, las islas Canarias estaban circunscritas al modelo jurídico castellano, a la vez que se apreciaba en su práctica judicial la relevancia de la discrecionalidad. Al mismo tiempo, de la lectura de los autos se desprende la proyección de las circunstancias sociales y económicas en los comportamientos transgresores. En suma, el presente estudio pretende contribuir a los conocimientos actuales sobre el ejercicio de justicia en los territorios de señorío en la referida centuria.
Local Government Expenditures, Institutional Quality and the Inclusive Economic Development Index (Iedi) in Indonesia
Authors: Mardiyani Baiq Yeyen , Budiono Budiono , Kemal Hidayat Achmad
Published: March 2024

The purpose of this study was to determine the effect of local government spending and institutional quality on the inclusive economy in Indonesia. To avoid the problems of endogeneity and omitted variable bias, the method used in this study is the system generalized method of moments (GMM). It was found that local government spending on housing and social functions positively and significantly affected the Inclusive Economic Development Index (IEDI). In contrast, government spending on health had a significant negative effect. Spending on education had an insignificant negative effect, while investment had a positive and significant effect on IEDI. The corruption rate as a proxy for the quality of institutional processes had a significant adverse impact on IEDI. This study provides an overview of the role and influence of local government policies and institutional quality that affect the region’s development and inclusive economic growth.
RISCO DE QUEDAS EM PACIENTES COM DIABETES MELLITUS TIPO 2
Authors: Sousa Sara Maria Ferreira de , Sardinha Ana Hélia Lima , Rodrigues Zulimar Marita Ribeiro
Published: March 2024

As quedas constituem um importante problema de saúde pública em virtude de sua grande incidência e dos desfechos que elas podem ocasionar. Assim como as quedas, os casos de Diabetes têm aumentado mundialmente nos últimos anos, sendo os pacientes diabéticos mais susceptíveis a estes eventos. O objetivo deste estudo é avaliar o risco de quedas em pacientes com Diabetes mellitus tipo 2. Trata-se de um estudo transversal com abordagem quantitativa, realizado no período de agosto de 2021 a junho de 2022, com 373 pacientes diabéticos. Utilizou-se um questionário para caracterização dos aspectos sociodemográficos e clínicos, e a Escala de Quedas de Downton para avaliação do risco de quedas. Foram realizadas análises descritivas e inferenciais. Os resultados demonstraram que 53,6% dos pacientes diabéticos relataram quedas após o diagnóstico de diabetes e 89% apresentaram alto risco de quedas. Concluiu-se que a maioria dos pacientes com Diabetes mellitus tipo 2 apresentam alto risco de quedas, sendo que os aspectos sociodemográficos apresentaram significância quanto a ocorrência de quedas prévias. Destaca-se a necessidade de maior atenção a ser dada no cuidado ao paciente diabético no que diz respeito ao risco e a prevenção de quedas.
Escola da cidade denominada como escola do campo no município de Botuporã, Bahia - Brasil
Authors: Amaral Cleonice Matos , Mateus Kergilêda Ambrósio de Oliveira
Published: March 2024

Neste artigo, apresentamos algumas reflexões no intuito de situar o movimento histórico, dialético, material e contraditório de Escolas do Campo, localizadas na cidade, bem como retomamos o debate sobre a centralidade da escola pública como um espaço fundamental de lutas da Educação do Campo. Como problema de pesquisa questionamos os sentidos atribuídos pelos sujeitos do Colégio Estadual do Campo de Botuporã (CECB) à sua nova denominação enquanto Escola do Campo. O objetivo geral visa a compreender os sentidos atribuídos pelos sujeitos do CECB à Escola do Campo. Já o arcabouço teórico e os dados empíricos foram construídos no decorrer da pesquisa de Amaral (2023), defendida junto ao Programa de Pós-Graduação em Ensino, da Universidade Estadual do Sudoeste da Bahia (UESB). Trata-se de uma pesquisa participante, de abordagem qualitativa, cujo método recorreu ao Materialismo Histórico Dialético e a produção de dados às técnicas de rodas de conversa e entrevista semi-estruturada para ouvir os 24 participantes da pesquisa. Os dados produzidos foram submetidos à análise de conteúdo de Bardin. Os resultados evidenciaram que os estudantes e os profissionais participantes da investigação reconhecem, de forma positiva, a nova denominação da escola, no entanto, não veem sentido na mudança apenas do nome, uma vez que as práticas educativas da referida instituição ainda não foram modificadas e não estão convergentes com os princípios da Educação do Campo, ou mesmo com os interesses dos sujeitos campesinos de Botuporã. Logo, apesar do novo nome, o CECB, continua sendo uma escola urbana.
Study of recycling of carbon tailings from Portland cement pro-duction
Authors: Mendes Bernal Arlindo , Messias Soares Mariana , Gustavo Mendes de Jesus Leandro
Published: March 2024

In the clinker Portland production process, rotary kilns burn fuels to reach temperatures as high as 1450 °C. In the Mato Grosso do Sul State, the most common fuel used in such kilns is grounded charcoal. After the grinding steps, charcoal is sieved, and the re-tained material is discarded as tailings. Despite such materials have some carbon matter in its composition, it is a high ash content material. This work is based on the hypothesis that, during the grinding of the material, organic compounds would break in finer particles since they show lower abrasive strength. Thus, ash materials would remain in the coarser particles. The goal of the work is to evaluate the viability of the use of charcoal fines in Portland cement to reuse the material in clinker Portland production. To achieve the proposed goal, fines were fractionated in different particle sizes. Each size fraction was characterized regarding its ash content, proximate analysis, and calorific value. The results allowed to relate size fraction with ash content and calorific value. The results revealed that coarser size fractions (retained in 0,500 mm) presented lower ash content and calorific value. Furthermore, such size fractions correspond to 24,04 % in mass of material.
Lung cancer, predictive factor and ERCC1
Authors: Souilah Souad
Published: March 2024

Introduction: Excision repair cross-complementing group 1 (ERCC1) counteracts the cytotoxic effect of cisplatin through its role in DNA repair, and its expression level is a crucial factor for sensitivity to this drug. The objective of this study was to assess the impact of ERCC1 on tumor response and survival in patients with advanced non-small cell lung cancer (NSCLC) treated with a platinum-based regimen.
Methods: Analysis of survival and tumor response based on the expression level of ERCC1 (detected by immunohistochemistry) in a cohort of NSCLC patients followed in a standard care setting.
Results: Among the 77 cases of NSCLC included, ERCC1 expression was low in 64.9% of cases and high in 35.1% of cases. In the 52 patients treated with cisplatin, survival and tumor response were better in the low-expression group compared to the high-expression group: 14.35 months versus 9.49 months, p=0.022; Objective Response: 42.4% versus 0%, p=0.001. No significant difference was found based on protein expression level in patients treated with carboplatin.
Conclusion: ERCC1 overexpression in patients treated with cisplatin predicts a poor tumor response and shorter survival.
Cystitis in pediatric age group and its empirical therapy in a coastal region of southern India
Authors: K.L Shobha , Rao S Gowrish
Published: March 2024

Cystitis in childhood, is a common health issue causing morbidity and mortality. This study was to find out the bacterial pathogens causing cystitis in children and its susceptibility pattern. 1792 urine specimens from 1day- 18 years of age suspected of cystitis were obtained. Samples were inoculated into culture plates. Identification of the pathogens was by MALDI-ToF mass spectrometry and antimicrobial susceptibility testing by VITEX 2 system (bioMerieux,Inc, Durham, NC). 48.38% were males and 51.61% were females, 65% attended outpatient department and 35% were admitted in the hospital. Cystitis was more frequently seen in less than one year. Samples when on inoculation into the culture plates, had no organisms in 69.31% and 30.69% had significant bacteriuria. Bacteriuria among boys was more frequently seen in the age group of less than one year of age (35.06%) in the females, bacteriuria was more commonly seen in the age group of 1-5 years (28.32%). Escherichia coli 63.45% was the commonest pathogen isolated. Susceptibility to Trimethoprim/sulphamethoxazole was 84.53% and Ampicillin 45.56% .Since Trimethoprim/sulphamethoxazole is an FDA approved and cost effective drug, it could be an empirical drug of choice for treating cystitis in children of more than 6 weeks of age in the developing countries.
Correlation trend between the bulk modulus, micro hardness and the lattice parameter of III-V semiconductors
Authors: Mezouar Rabie , Bioud Nadhira , Benmakhlouf Abdelfateh
Published: March 2024

This work aims to investigate the correlation between the bulk modulus as well as the microhardness and the lattice parameter of several cubic zinc-blende III-V semiconductors. Our study shows that both the bulk modulus and the microhardness correlate no-linearly with the lattice parameter of III-V binary compounds. The best fits were obtained using the Gaussian model, the coefficients of the correlation were found at around 0.993 for the bulk modulus, and 0.996 for the microhardness, respectively. Our expressions perhaps used with high accurate to predict the bulk modulus and the microhardness of other binary compounds and ternary semiconductor alloys.Â Â Â
Compressive strength of manganese fine-grained material and molasses briquettes regarding binder content and curing time
Authors: Rondon Gonçalves Dhaffiny , Gustavo Mendes de Jesus Leandro
Published: March 2024

In the production of raw materials for the manufacture of ferroalloys, up to 50% of the material mined is discarded as fine-grained tailings. Those tailings are deposited in dams, which are considered an environmental liability. To avoid this, an alternative would be to agglomerate the tailing dam materials using the briquetting process. Therefore, this work aims to evaluate the compressive strength of briquettes made of manganese fine-grained material (with particle size < 2.00 mm) and molasses regarding curing time and percentage of binder. To achieve the objective, 45 briquettes were made with fine-grained manganese ore, with 3 different molasses content (binder), these were put into 3 weeks of curing, to analyze the impact of binder content and curing time. The result was that the longer the curing time, the better the compressive strength and that increasing binder content reduces its compressive strength. Finally, the best results were obtained with 5 % binder and 3 weeks of curing time, in which the agglomerate produced had a compressive strength of 9,0 MPa.
Expected pharmacological influences related to alkaloids extracted from flavedo peel layers of citrus fruits
Authors: M. I. Abdelgadir
Published: March 2024

This study was focused at Extraction of Alkaloids from Flavedo layers of Citrus Fruits peels and its Expected Anti-Oxidant Influences on Human Health. Alkaloids have a wide range of pharmacological activities. Albedo extract was separated. Study results clearly showed the presence (p ≤ 0.05) of alkaloids in Albedo citrus peel layers compared to control. Phytochemicals are major bioactive compounds known for their health benefits. They contain significant amounts of alkaloid, which exist in edible and non-edible parts of citrus fruits.
Exercise training: which impact on COPD patients?
Authors: Djebaili R. , Chiboub B.
Published: March 2024

Introduction: Exercise training reactivates the aerobic pathway through physical exercise, thereby improving dyspnea and breaking deconditioning spiral in chronic obstructive pulmonary disease (COPD) patients.
Method: 60 COPD patients were selected to benefit from a four-week outpatient exercise training and muscle strengthening program, at a rate of 3 sessions per week, after excluding the following cases: patients who have contraindications to exercise training; severe patients or those receiving long-term oxygen therapy. The program combined exercise training on a bicycle ergometer for 45 min, muscle strengthening of the lower limbs and nutritional monitoring. Nutritional management included a diet based on nutritional status and the prescription of oral food supplements for malnourished COPD patients. Parameters assessed before and after training were bioimpedance analysis (BIA),6MWT, quadriceps isometric voluntary contraction (MVC) and dynamic endurance, and the quality-of-life questionnaire (Q11).
Result: Forty COPD patients (36 men and 4 women) aged 67.22 (± 10) years were able to complete the program. Amid them, 36 were non-smokers. Ten patients (GOLD I), 14 patients (GOLD II), 16 patients (GOLD III), no patients (GOLD IV). Dyspnea was stage 2 (± 1) m MRC. After training, quadriceps muscle function ((MVC) and endurance) improved significantly (p < 0.0001). The improvement in distance covered during 6MWT was also significant (p < 0.0001). A significant improvement in quality of life after training was noted on the total score of the Q11 questionnaire. No significant improvement in body composition after training in COPD patients.
Conclusion: this study has confirmed the beneficial effects of training mainly on muscle function, effort capacity and quality of life in COPD patients.
ANALYSIS OF CREATIVE THINKING SKILLS ON THE PHYTHAGOREAN THEOREM MATERIAL IN TERMS OF SELF-CONFIDENCE
Authors: Alyani Fitri , Mercury Aminanti Narin Ledy
Published: March 2024

The purpose of this study is to describe the ability of students' creative thinking processes on the Pythagorean theorem material which is reviewed based on self-confidence. The subjects of this study were Junior High School students at grade VIII in Jakarta, as many as 120 students. This study uses a qualitative method with a descriptive approach. The stages carried out are: filling out a self-confidence questionnaire, testing creative thinking skills with Pythagoras theorem questions, interviews, analyzing data, drawing conclusions. Based on the results obtained, the high self-confidence classification of students affects the students' high mathematical creative thinking skills as well. Classification of self-confidence is moderate, then the students' mathematical creative thinking ability is quite good. Conversely, if the classification of a student's self-confidence is low, then a student’s mathematical creative thinking skills is also low.

Keywords: Creative Thingking Skill, Pythagorean Theorem, Self-Confidence
Development of Liveworksheet Assisted Teaching Materials for Students' Mathematical Problem-Solving Ability
Authors: Teddy Ronny Renata , Hidayat Wahyu
Published: March 2024

Problem-solving ability is one of the hard skills that students need to solve everyday math problems. The learning model is felt to be in line with the ability to solve mathematical problems, namely the problem-based learning model because learning can be oriented to the ability to solve various problems, especially those related to the application of learning materials in everyday life. This study aims to develop teaching materials in the form of student worksheets with a problem-based learning model assisted by Liveworksheet on students' mathematical problem-solving abilities. This study used the development research method in two stages, namely preliminary design and formative evaluation design which was conducted on 50 junior high school students. Data collection techniques used are content validity by expert judgement and test. The instruments are expert assessment sheet and question sheet after content validity being conducted. Data analysis is done by finding the average of expert validation and learning achievement score. It is continued by comparing the score of validity and effectivity criteria. The results show that the student worksheets assisted by Liveworksheets and the developed mathematical problem-solving abilities are categorized as very valid and effective.
Correção de nariz em sela usando enxerto de calvária em cantiléver e malhas de titânio.
Authors: Ferraz Caio Augusto Munuera Ueti , Santos Felipe Daniel Búrigo dos , Chiarelli Murillo
Published: March 2024

Introdução: Sinais e sintomas nasais de fraturas complexas naso-órbito-etmoidais incluem selamento do dorso nasal, anosmia por dano à lâmina cribiforme e congestão nasal por deformidade traumática óssea ou cartilaginosa. Clinicamente, o nariz em sela é caracterizado por um dorso nasal colapsado, que pode ser corrigido por meio de enxerto em cantiléver do osso parietal. Objetivo: Este artigo apresenta um relato de caso de correção tardia de nariz em sela em um paciente jovem, com sequela residual de uma fratura panfacial, usando enxerto em cantiléver de osso parietal autógeno e malhas de titânio, para proporcionar um melhor contorno do dorso nasal. Resultado: No pós-operatório, observou-se melhora significativa do contorno nasal e projeção do dorso nasal. Conclusão: Em pacientes com fraturas naso-órbito-etmoidais complexas, que apresentem selamento do dorso nasal, o enxerto de osso parietal em cantiléver é uma opção de tratamento para ganho de projeção do dorso nasal. As malhas de titânio fornecem um auxílio valioso para melhora do contorno da região naso-órbito-etmoidal nasal, podendo ser apoiadas no próprio enxerto.