bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengimplementasian Legenda Calon Arang sebagai Edukasi Budaya Nusantara dan Feminisme Melalui Animasi
Authors: Antika Tiara Mara , Rachman Anung , Kurniawan Rendya Adi
Published: August 2022

In ​​​​Bali, there are famous traditional theaters that contain feminism values, namely the leak show or the legend of Calon Arang. The purpose of this research is the creation of 2D animated character works as an education for Indonesian culture and feminism. The method used is sprint design. The results of this study are (1) The production of 2D Calon Arang animated characters that promote Balinese culture, (2) Feminism in the Past and Present, Application of Balinese Cultural Values ​​in the Design of 2D Calon Arang Animated Characters (3). 2D animated characters made using the rigging bone technique with a thick Balinese feel can be a means of fostering a sense of pride in the culture of nusantara and as a symbol of past feminism.
Pada daerah Bali terkenal teater tradisional yang mengandung nilai feminisme yaitu pertunjukan leak atau legenda Calon Arang. Tujuan penelitian ini adalah terciptanya karya karakter animasi 2D sebagai edukasi budaya nusantara dan feminisme. Metode yang digunakan adalah desain sprint. Hasil penelitian ini adalah (1) dihasilkannya karakter animasi 2D Calon Arang yang mengangkat budaya Bali, (2) feminisme di masa lampau dan masa kini, penerapan nilai budaya bali pada desain karakter animasi 2D Calon Arang (3), karakter animasi 2D dibuat dengan teknik rigging bone dengan nuansa Bali yang kental dapat menjadi sarana menumbuhkan rasa bangga terhadap budaya nusantara serta sebagai simbolis feminisme masa lampau.
Pengembangan Media Pembelajaran Learning Management System (LMS) Berbasis Moodle pada Materi Perubahan Energi
Authors: Fikriyah Agnia Nur , Sukmawati Wati
Published: August 2022

This research is a research about Learning Management System (LMS) development. In this case, the media being developed is Moodle-based media that contains materials about energy transformation. This research is conducted to develop Moodle-based learning media, namely the one which contains material about energy transformation. This media  is developed in research and development process, and implemented with ADDIE model. It can be done through 5 steps, such as Analysis, Design, Development, Implementation and Evaluation. The result will be Moodle-based energy transformation material for grade IV students. The result can be obtained through verification by both the media expert and material expert, also by testing the media to the students. Then, we can analyze all data obtained by implementing Likert scale with quantitative approach. After testing and verification process are all done, we can know that: (1) media expert: validity score 78,67%, (2) material expert: validity score 87,5% and (3) student testing score 86,61%. From the research's result we can infer that Moodle-based Learning Management System (LMS) containing energy transformation material is very suitable for elementary school students. It also can be used as supplementary media during natural science class.

Penelitian ini merupakan penelitian mengenai pengembangan media pembelajaran Learning Management System (LMS) yang berbasis moodle. Tujuan dari penelitian ini adalah untuk mengembangkan media belajar berbasis moodle pada materi perubahan energi. Media pembelajaran ini dikembangkan dalam penelitian dan pengembangan atau Research and Development dan diterapkan menggunakan model ADDIE dengan 5 langkah yaitu: Analysis, Design, Development, Implementation dan Evaluation. Hasil produk akhir dari pengembangan ini yaitu media pembelajaran berbasis moodle materi perubahan energi untuk kelas IV. Hasil data penelitian diperoleh melalui proses validasi ahli media, ahli materi serta uji coba peserta didik. Data hasil penelitian di analisis dengan skala likert menggunakan pendekatan kuantitatif. Data penilaian hasil validasi dan uji coba siswa dengan perolehan sebagai berikut: (1) ahli media 78,67%, (2) ahli materi 87,5% dan (3) uji coba siswa 86,61%. Berdasarkan hasil perolehan data menunjukkan bahwa pengembangan media pembelajaran Learning Management System (LMS) berbasis moodle pada materi perubahan energi memenuhi kriteria sangat layak digunakan siswa sekolah dasar serta dapat digunakan sebagai penunjang pembelajaran IPA.
Pengembangan Media Pembelajaran Augmented Realty pada Materi Struktur Tumbuhan Sekolah Dasar
Authors: Irawan Lutfi , Yatri Ika
Published: August 2022

The rapid development of digital technology should be utilized in the field of education such as the implementation of Augmented Realty media in learning. This study aims to develop science learning media for plant structure and function with Augmented Realty class IV. This study used a 4D model which has four stages, namely, Define, Design, Development and Disseminate. Based on the validation test of media experts and material experts, the results of the assessment of Augmented Realty media as a whole were 97.49% and 94.44%, respectively, and media trials on 31 grade IV students obtained a percentage of 93.16%. Based on the acquisition of data, it shows that the learning media can be said to be suitable for use.

Perkembangan teknologi digital yang semakin pesat sudah seharusnya dimanfaatkan pada bidang pendidikan seperti implementasi media augmented realty pada pembelajaran. Penelitian ini bertujuan untuk mengembangkan media pembelajaran IPA materi struktur dan fungsi tumbuhan dengan Augmented Realty kelas IV. Penelitian pengembangan ini menggunakan model 4D yang memiliki empat tahap yaitu, Define, Design, Development dan Disseminate. Berdasarkan uji validasi ahli media dan ahli materi diperoleh hasil penilaian media Augmented Realty secara keseluruhan berturut turut 97,49% dan 94,44 % serta uji coba media pada 31 siswa kelas IV memperoleh presentase 93,16%. Dengan demikian, media AR Struktur dan Fungsi Tumbuhan yang baru pertama kali diperkenalkan dan diimplementasikan di SDN Kamal 01 Pagi sehingga para siswa kelas IV sangat antusias dalam menggunakan media tersebut.
Pengaruh Media Pembelajaran Powtoon Terhadap Hasil Belajar Matematika pada Materi Perkalian Siswa Kelas II Sekolah Dasar
Authors: Aliyah Afifatul Aliyah , Purwanto Sigid Edy
Published: August 2022

The purpose of this study was to find out whether the use of Powtoon learning media affects the outcome of mathematics learning in elementary school multiplication materials. This study used a quantitative experiment method with a pre-test-post-test non-equivalent control design. The sample for this study was 40 students divided into Class II-A as an experimental class with 20 students and Class II-B as a control class with 20 students. In processing the data, researcher tested the analytical requirements, which consisted of a normality test using the Liliefors test with normal distribution results, and a homogeneity test for pre-test and post-test data using the Fishers test with homogeneous data results. The result of the hypothesis test using the t-test is tcount> ttable (30,098> 2,0930). From the result, it can be concluded that there is an effect of Powtoon learning media on mathematics learning outcomes in elementary school multiplication materials.

Tujuan dilakukannya penelitian ini ialah menganalisis apakah terdapat pengaruh penggunaan media pembalajaran Powtoon pada hasil belajar matematika khususnya untuk materi perkalian sekolah dasar. Penelitian ini menerapkan metode kuantitatif menggunakan desain Pretest-Posttest nonequivalent control grup. Kemudian, sampel yang digunakan ada 40 siswa yang terbagi menjadi kelas eksperimen yakni kelas II-A sejumlah 20 anak dan kelas kontrol (kelas II-B) sejumlah 20 anak. Data diolah dengan melakukan uji persyaratan analisis, yakni uji normalitas dengan uji liliefors dengan hasil berdistribusi normal dan uji homogenitas data pretest dan post tes menggunakan uji fisher dengan hasil data homogen. Hasil pengujian untuk hipotesis dengan menerapkan uji-t dengan hasil thitung > ttabel (30,098 > 2,0930). Mengacu pada hasil yang diperoleh, disimpulkan bahwa ditemukan pengaruh media pembelajar powtoon pada hasil belajar matematika untuk materi perkalian siswa sekolah dasar.
X-Linked Hypophosphatemic Rickets: A Pediatric Case Report
Authors:   Clínica Universitária de Pediatria, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal, Almeida Isabel , Rodrigues Ana ,   Pediatric Nephrology and Kidney Transplantation Unit, Pediatrics Department, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Lisbon, Portugal, Costa-Rei Ana ,   Clínica Universitária de Pediatria, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal,   Pediatric Nephrology and Kidney Transplantation Unit, Pediatrics Department, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Lisbon, Portugal, Stone Maria ,   Clínica Universitária de Pediatria, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal,   Pediatric Nephrology and Kidney Transplantation Unit, Pediatrics Department, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Lisbon, Portugal
Published: August 2022

X-linked hypophosphatemic rickets is a monogenic disease, characterized by hyperphosphaturia and hypophosphatemia. Due to its rarity and wide phenotypic variability, a diagnostic delay is common in X-linked hypophosphatemic rickets. Short stature, limb deformities, dental anomalies, craniosynostosis and chronic pain are common in this disease. Recently, burosumab, a monoclonal antibody anti-fibroblast growth factor 23, was approved for the treatment of X-linked hypophosphatemic rickets. Awareness among clinicians must be increased to improve the care of these patients. We present a clinical case of a 4-year-old girl presented with deformities of the lower limbs and an abnormal gait, associated with hyperphosphaturia and hypophosphatemia. Asymptomatic Arnold Chiari malformation was identified. No dental problems were detected. The diagnosis of X-linked hypophosphatemic rickets was confirmed by the identification of a PHEX mutation. The patient developed diarrhea, nephrocalcinosis, and hyperparathyroidism secondary to conventional therapy with phosphate supplements. Burosumab was initiated with a fast increase on serum phosphate levels and a decrease on alkaline phosphatase. With the description of this case, we highlight the clinical manifestations and complications of X-linked hypophosphatemic rickets and its treatment and we discuss new treatment strategies to improve the quality of life of these patients.
Potential applications of additive manufacturing technologies in the vehicle industry
Authors: Alzyod Hussein , Ficzere Péter
Published: August 2022

One of the most competitive fields on the planet is the automotive industry. Newmarket and innovative designs regularly arise, necessitating the development of new manufacturing methods to keep up with the automotive industry. Additive manufacturing offers a significant competitive advantage in this industry, serving as a disruptive strategy by increasing production flexibility, reducing product development time, and providing optimal automotive components and bespoke vehicle products on demand. Additive manufacturing on soft assembly tools or specialised tools to make automotive components enhances automotive production. Additive Manufacturing’s freeform capability allows for the design and direct fabrication of optimised automotive components aimed at improving vehicle performance, as well as tailored assembly tools to boost productivity. Another related technological advantage of additive manufacturing is the ability to create lightweight components with the help of generative design algorithms. Furthermore, the time to market for Additive Manufacturing parts has fallen dramatically, allowing mass customisation to become a reality. The strong downward trend in fuel consumption offers new automobile design, performance, and compliance with regulations. Considering the actual example switch from the conventional combustion engine to other motion systems, Additive Manufacturing is a critical enabler technology for modern automobiles. This paper provides an overview of Additive Manufacturing applications in the automobile sector, focusing on the technical and economic benefits of this manufacturing technology.
Benefits and limitations of acoustic methods in the vehicle transmission diagnostics
Authors: Kriston József Balázs , Jálics Károly
Published: August 2022

In general, for the diagnostics of a faulty machine several diagnostic methods can be considered. In this paper, the benefits and limitations of the acoustic diagnostic methods are shown, based on a noise problem of a real car with a 6-speed manual transmission. The possible diagnostic methods will be pointed out, and an analysis will be performed with noise and vibration measurements on the car. Based on the analysis conclusions regarding the benefits and limits of the used diagnostic method will be drawn.
Analysis of the Characteristics of Agenda Setting Theory in the New Media Era
Authors: Hao Xu
Published: August 2022

One of the traditional theories of communication, agenda-setting theory, has seen significant growth in the context of new media along with the advancement of Internet technology. However, in the new media environment, agenda-setting theory also faces many challenges, leading to some subverted classic ideas. In this paper, the author tries to examine the agenda-setting theory and the phenomena that have led to its development and change, looking at diversified agenda-setting subjects, significant new media user counteraction, traditional mainstream media still playing a leading role, and legacy media interacting with new media. It then provides some examples to support its arguments.
Efficiency Increase of Biological Methanation based Power-to-Methane Technology Using Waste Heat Recovery with Organic Rankine Cycle
Authors: Groniewsky Axel , Kustán Réka , Imre Attila
Published: August 2022

Due to the efforts of reducing greenhouse gas emissions, nearly two-thirds of the installed electric capacity worldwide will come from renewables in 2050 (EIA 2021), making frequency control without energy storage impossible. Power-to-Methane (PtM) technology allows electricity to be stored in the form of methane. The storage efficiency of PtM may be increased either by maximizing the recovery of the stored electricity, which is a common method, or by reducing the amount of electricity the PtM has to be charged with for a given amount of stored energy. In this paper, a case study is presented for the latter by directly integrating an Organic Rankine Cycle into the PtM technology by recycling the waste heat from water electrolysis and biological methanation back to electrolysis. With this method, total storage efficiency can be increased by approximately two percentage points.
Interval Type2 Fuzzy Logic Based STATCOM Controller for Stabilizing a Mixed Electrical Network System
Authors: Kadri Abdellah , Makhloufi Salim
Published: August 2022

Adding renewable energy plants to the electrical grid reduces the performance of energy systems. This results in problems including power fluctuations and poor voltage quality. This paper presents an interval type2 fuzzy logic-based controller, consisting of current and voltage regulators, that is applied to a STATCOM to regulate the DC voltage under various operating conditions. a membership functions not used before in this filed have been used to generate IT2FL sets output. The STATCOM has been connect with the high voltage bus bar in order to use one STATCOM for all the loads According to comparative studies, the proposed method outperforms traditional PI and type1 fuzzy logic-based controllers.The simulation has been implemented using MATLAB/SIMULINK software and the results confirm the feasibility of the proposed system.
Reform a könyvtárstatisztikában: egységesített adatstruktúra és adatvizualizáció
Authors: Noémi Erika Békésiné Bognár , Andor Nagy
Published: August 2022

A Könyvtári Intézet elődjével, a Könyvtártudományi és Módszertani Központtal egyetemben 1995 óta a könyvtárstatisztikai adatszolgáltatás menedzselője, tehát az intézet szervezi az adatgyűjtést és teszi közzé az eredményeket. Az adatszolgáltató felület teljes megújítására 2020-ban került sor. A Könyvtári Intézet Kutatási és Elemző Osztály kollégái a 2021-es évben 2015-ig visszamenőlegesen átfogó adattisztítást végeztek, és kialakítottak egy olyan egységes adatstruktúrát, amelynek révén a 2015 és 2020 közötti évek adatai elemi szinten is könnyen összehasonlíthatóvá váltak. A munka eredményeképp a részletes szakmai, tudományos elemzésekhez elérhetővé váltak Excelben és SPSS-ben is jól kezelhető adatállományok. Az adatok könnyű és gyors áttekinthetősége érdekében korszerű, adatvizualizációs eszközök segítségével, webes felületen válik megtekinthetővé a Magyarországon működő könyvtári szolgáltatási pontok számának, működésének, szolgáltatásainak és használatának alakulása. Ezenfelül, a Kutatási és Elemző Osztály munkatársai egy új elektronikus kiadványsorozatot indítottak, a „Könyvtári trendjelentések”-et, amely jelenleg tizenkét tematikus riportból áll, bemutatva az elmúlt években a hazai könyvtári rendszerben bekövetkezett főbb változásokat.
Evaluación del rendimiento en consumo de combustible y emisiones contaminantes del vehículo segmento A, aplicando la simulación de ciclo IM 240 en la ciudad de Riobamba.
Authors: Molina López Jorge Oswaldo , Solís Santamaria Javier Milton , Masaquiza Yanzapanta Ángel Guillermo , Rocha Hoyos Juan Carlos
Published: August 2022

En base a estudios previos de emisiones de gases a nivel mundial, partió el objetivo de análisis de los factores de emisión originados por los combustibles Super y Extra en un vehículo de segmento A; al cual se le someterá a pruebas en un dinamómetro, bajó las características de simulación de conducción  IM240, también se utilizó el analizador de gases MAHA, y un recipiente presurizado para evaluar el rendimiento bajo la condición de altura de 2754 msnm de la ciudad de Riobamba. Una vez estimados los factores de emisión de CO, HC y NOx para cada combustible (g/km) se realizó el análisis estadístico mediante el software STATGRAPHICS, donde con el análisis de varianza (ANOVA) y el procedimiento de diferencia mínima significativa (LSD) de Fisher. Se determinó que existe una diferencia representativa en la generación de CO para ambos combustibles, pero con un comportamiento similar para HC Y NOx con un nivel de confianza del 95%. Además, el rendimiento del líquido operante es más eficiente con el combustible Super, con un 11% adicional en su autonomía.
El comportamiento de los empleados públicos de Guayaquil incide en la satisfacción de los usuarios
Authors: Carrera López Jean Steve , Bedor Vargas Deyton Darío , Huacón Arévalo Manuel Orlando
Published: August 2022

Introducción: La velocidad de los cambios tecnológicos y la globalización hace que la cantidad de información cada día sea mayor, con ello las necesidades de las personas, por lo cual sus exigencias son mayores en cuanto a la atención requerida para algún servicio. Por esa razón las entidades públicas deben velar porque el personal cuente con las competencias para una atención de calidad. Por su parte, el Estado, se han encargo de generar las leyes y normativas para garantizar que los procesos y la atención a los usuarios sea eficiente.  No obstante, las instituciones públicas de Guayaquil aún requieren ajustes a fin de evitar esta situación y es allí donde radica la importancia de esta investigación, ya que, a través de las diferentes posiciones de los autores, se pudo internalizar sobre los puntos más resaltantes sobre los usuarios, los servidores públicos, las leyes, normas y procedimientos existente en Ecuador. Se usó una metodología de tipo documental, basada en el diseño bibliográfico. Con ello, se evidenciar que en Guayaquil se hace indispensable que las autoridades no solo se enfoquen en generar leyes, sino que la debe velar por el cumplimiento de sus procesos administrativos siguiendo las pautas legales existentes para ello.
La sociedad de acciones simplificadas, dentro del contexto de contractualización entre cónyuges en el Ecuador
Authors: Vásconez Fuentes José Luis , Jaramillo Rubio Lorena Alexandra , Cortez Ocaña Mayra Paola
Published: August 2022

Introducción. Las SAS son un tipo de compañía mercantil que se constituye por una o varias personas naturales o jurídicas, mediante un trámite simplificado sin costo. Tiene como objetivo impulsar la economía mediante la formalización de los emprendimientos, constituyéndolos en sujetos de crédito y con ello ampliar sus procesos productivos. Objetivo. Se pretende abordar acerca de la sociedad de acciones simplificadas “SAS”, dentro del contexto de contractualización entre cónyuges en el Ecuador. Metodología. Se aplicó una metodología basada en un diseño bibliográfico de tipo documental. Resultados. El consecuente inicio de actividades de las SAS a la reglamentación ecuatoriana desde un ángulo positivo sujeta una herramienta legal en donde los pequeños y medianos empresarios, e incluso los grandes empresarios cuenten con un instrumento que apoyándose en el principio de autonomía de la voluntad consienta las actuaciones en una colectividad estructurada en favor de sus intereses económico, al transcurrir el tiempo se logrará dar un análisis real en relación al beneficio práctico. Conclusión. las compañías de acciones simplificadas representan un hito en la contractualización entre cónyuges en el Ecuador, en primer lugar, por la facilidad de constitución adicional y cero costos operativos, paralelamente la flexibilización de las formalidades lo que la hace muy atractiva. Comparablemente la posibilidad de recubrir a los patrimonios familiares con la responsabilidad limitada, se constituye en un factor muy importante a considerar en especial en los precisos momentos en que por efectos de la pandemia COVID-19 la economía nacional se ha visto sumamente afectada y en donde corren grave riesgo de embargos los bienes de participantes en las sociedades conyugales.
Gamificación: estrategia que motiva el aprendizaje en entornos virtuales de los niños del nivel preparatoria
Authors: Quingaluisa Sasintuña Jessica Alexandra , Mena Hernández Liliana del Rocío
Published: August 2022

Introducción. Por la situación pandémica mundial que se atraviesa   se considera aplicar la gamificación como proceso de aprendizaje en entornos virtuales, puesto que se introduce el juego en el ámbito educativo, motivo por el cual el juego trabajo es la metodología que se emplea en edades tempranas para lograr experiencias significativas y la vez mejorar la práctica docente, como Objetivo. de esta investigación es Implementar la gamificación para el desarrollo de la motivación por aprender en entornos virtuales de los niños del nivel preparatoria de la Unidad Educativa “Salcedo”.  Metodología. En tal virtud la investigación se basa en la modalidad cuantitativa, con alcance descriptivo y explicativo, partiendo del análisis de datos recopilados para explicar las características y propiedades del grupo de estudio. El método para utilizar es de nivel teórico: análisis y síntesis, hipotético deductivo y del nivel empírico: la observación directa (zoom) a niños de cinco años y encuesta en línea a sus representantes. Resultados como resultados se obtuvo la confiabilidad del instrumento con un alfa de Cronbach de ,810 y en la prueba de normalidad un valor de 0.00 la misma que rechaza la hipótesis nula y acepta la hipótesis alterna de manera altamente significante Conclusiones se puede concluir que la aplicación de la gamificación si motivo al estudiante a tener un aprendizaje significativo en un tiempo reducido.
DIAGNOSIS KESALAHAN PESERTA DIDIK DALAM MENYELESAIKAN SOAL MATEMATIKA POKOK BAHASAN LINGKARAN KELAS VIII SMP NEGERI 7 KOTA BENGKULU
Authors: Muniroh Fauziatul , Yensy Nurul Astuty , Muchlis Effie Efrida , Siagian Teddy Alfra
Published: August 2022

Penelitian ini merupakan penelitian deskriptif untuk mengetahui kesalahan apa saja yang dilakukan peserta didik dalam menyelesaikan soal matematika pokok bahasan lingkaran kelas VIII SMPN 7 Kota Bengkulu Tahun ajaran 2019/2020. Sebanyak 29 peserta didik kelas VIII C dipilih sebagai subjek penelitian ini. Instrumen dan teknik pengumpulan data yang digunakan dalam penelitian ini adalah lembar tes. Hasil penelitian menunjukkan bahwa bentuk kesalahan yang dilakukan peserta didik dalam menyelesaikan soal tentang lingkaran yaitu: a) kesalahan menentukan unsur juring lingkaran dilakukan oleh 65,52% peserta didik, b) kesalahan menentukan tali busur lingkaran dilakukan oleh 20,69% peserta didik, c) kesalahan dalam menentukan konsep hubungan sudut pusat dan sudut keliling yang menghadap busur yang sama dilakukan oleh 17,24%  peserta didik, d) kesalahan dalam operasi bilangan bulat dilakukan oleh 31,03% peserta didik, e) kesalahan dalam menentukan rumus panjang lintasan pada roda yang berputar dilakukan oleh 31,03% peserta didik, f) kesalahan dalam menentukan rumus keliling atau luas lingkaran dilakukan oleh 24,14% peserta didik, g) kesalahan dalam menggunakan rumus untuk menentukan luas tembereng dilakukan oleh 37,93% peserta didik, dan h) kesalahan dalam menggunakan konsep untuk menghitung keliling daerah yang diarsir dilakukan oleh 13,79% peserta didik.
PENGEMBANGAN MEDIA KOSAMI BERMUATAN PENDIDIKAN KARAKTER PADA MATERI BANGUN RUANG SISI DATAR KELAS VIII SMP
Authors: Moniati Moniati , Astuti Reni , Hartono Hartono
Published: August 2022

Penelitian ini bertujuan untuk menghasilkan Kosami Bermuatan Pendidikan Karakter Pada Materi Bangun Ruang Sisi Datar Kelas VIII SMPN 10 Sungai Kakap yang valid dan praktis. Model Pengembangan yang digunakan adalah model Borg and Gall dengan 7 langkah yaitu, (1) Potensi dan Masalah (2) Pengumpulan Data (3) Desain Produk (4) Validasi Desain (5) Revisi Desain (6) Uji Coba Produk (7) Revisi Produk. Subjek penelitian adalah siswa kelas XI SMPN 10 Sungai Kakap. Teknik pengumpulan data yang digunakan adalah teknik komunikasi tidak langsung dengan alat pengumpul data lembar validasi ahli media, ahli materi, angket respon siswa dan respon guru. Ahli validasi terdiri dari 3 dosen program studi pendidikan matematika IKIP PGRI Pontianak dan respondent terdiri guru mata pelajaran matematika dan siswa SMPN 10 Sungai Kakap. Berdasarkan hasil validasi para ahli diperoleh aspek materi yang dinyatakan valid dengan persentase sebesar 84,7%, sedangkan aspek media dinyatakan sangat valid dengan hasil persentase sebesar 91,67%. Hasil angket respon guru memperoleh hasil sebesar 91,11% dengan kriteria sangat praktis. Dengan demikian, dapat disimpulkan bahwa Kosami bermuatan pendidikan karakter layak untuk digunakan.
Analisis Tingkat Kognitif Soal Uji Kompetensi Limit Fungsi Trigonometri pada Buku Siswa Matematika 3 Terbitan Grafindo Media Pratama Berdasarkan Taksonomi Bloom Revisi
Authors: Sawitri Diah , Hanifah Hanifah , Yensy B Nurul Astuty
Published: August 2022

Penelitian ini bertujuan untuk mendeskripsikan sebaran tingkat kognitif soal uji kompetensi limit fungsi trigonometri pada buku siswa matematika 3 terbitan Grafindo Media Pratama berdasarkan taksonomi Bloom Revisi. Taksonomi Bloom Revisi yang digunakan hanya pada dimensi proses kognitif yang terdiri dari C1 (Mengingat), C2 (Memahami), C3 (Mengaplikasikan), C4 (Menganalisis), C5 (Mengevaluasi), dan C6 (Mencipta). Jenis penelitian ini adalah penelitian deskriptif. Subjek penelitian ini adalah soal-soal uji kompetensi kecuali soal uji kompetensi awal, dalam bentuk uraian dan pilihan ganda pada buku siswa terbitan Grafindo Media Pratama untuk kelas XII matematika peminatan edisi revisi 2016, dengan pokok bahasan limit fungsi trigonometri. Hasil penelitian menunjukkan bahwa soal uraian uji kompetensi limit fungsi trigonometri memuat tingkat kognitif C2 (Memahami) dengan persentase 6,33% (5 soal), tingkat kognitif C3 (Mengaplikasikan) dengan persentase 63,29% (50 soal); soal pilihan ganda memuat tingkat kognitif C2 (Memahami) dengan persentase 6,33% (5 soal), tingkat kognitif C3 (Mengaplikasikan) dengan persentase 24,05% (19 soal); dan tidak terdapat tingkat kognitif C1, C4, C5, dan C6 pada soal uraian maupun pilihan ganda.
Analisis Metakognisi Siswa Dalam Memecahkan Masalah Barisan Dan Deret Bilangan Ditinjau Dari Kemampuan Matematis
Authors: Maulana Hanief , Rohim Abdur , Haryono Heny Ekawati
Published: August 2022

Tujuan dari penelitian ini adalah untuk mendeskripsikan metakognisi siswa kelas XI SMA Hasyim Asy’ari 1 Pucuk dalam memecahkan masalah Barisan dan Deret Bilangan pada siswa kemampuan tinggi, sedang dan rendah. Penelitian ini merupakan penelitian kualitatif deskriptif yang dilaksanakan secara daring menggunakan media sosial whatsapp. Instrumen penelitian ini adalah peneliti sendiri dengan didukung tes tulis dan wawancara. Subjek penelitian ini adalah enam siswa yang terdiri dari dua siswa dengan kemampuan tinggi, dua siswa dengan kemampuan sedang dan dua siswa dengan kemampuan rendah. Hasil dari penelitian ini menunjukkan bahwa siswa dengan kemampuan tinggi mempunyai pengetahuan deklaratif, pengetahuan prosedural dan pengetahuan kondisional dengan baik. Siswa dengan kemampuan tinggi juga mampu menggunakan keterampilan perencanaan, keterampilan monitoring dan keterampilan evaluasi yang baik. siswa dengan kemampuan sedang mempunyai pengetahuan deklaratif, pengetahuan prosedural yang baik dan pengetahuan kondisional yang cukup baik. Siswa dengan kemampuan sedang juga mampu menggunakan keterampilan perencanaan, keterampilan monitoring dengan baik dan tidak mempunya keterampilan evaluasi. Siswa dengan kemampuan rendah hanya mempunyai pengetahuan deklaratif. Siswa dengan kemampuan rendah juga hanya menggunakan keterampilan perencanaan.
PENINGKATAN PROSES DAN HASIL BELAJAR SAINS DENGAN MENGGUNAKAN METODE KERJA KELOMPOK PADA SISWA KELAS VB SDN 9 AMPENAN
Authors: Isniwati Isniwati
Published: August 2022

Penelitian tindakan kelas ini dilatar belakangi oleh beberapa permasalahan tentang pembelajaran Sains di kelas tinggi khususnya di kelas V.B. diketahui bahwa proses pembelajaran lebih dominan dan terpusat pada guru menyebabkan siswa menjadi pasif. Anggapan bahwa Sains pelajaran yang sulit merupakan salah satu penyebab dari rendahnya proses dan hasil belajar siswa, dilakukan kegiatan dengan menerapkan metode pembelajaran Kerja Kelompok. Tujuan penelitian ini adalah untuk meningkatkan proses dan hasil belajar Sains dengan menggunakan metode Kerja Kelompok. Penelitian ini dilaksanakan di kelas V.B SDN 9 Ampenan dengan jumlah siswa 44 siswa yang terdiri dari 24 siswa laki-laki dan 20 siswa perempuan. Penelitian ini dilaksanakan dalam 2 siklus, setiap siklus meliputi perencanaan, pelaksanaan, observasi, dan refleksi. Sumber data dari siswa diperoleh dari evaluasi hasil belajar dan hasil kerja kelompok LKS. Penelitian ini dikatakan berhasil jika terjadi peningkatan rata-rata hasil belajar siswa di tiap siklusnya, sekurang-kurangnya siswa mendapat nilai >65 dan ketuntasan belajar mencapai 85%. Berdasarkan hasil penelitian pada siklus I, diperoleh nilai rata-rata kelas 67,27 dengan persentase ketuntasan klasikal 68,18% dan rata-rata aktivitas siswa 9,33 dengan persentase 51,83%. Pada sikklus II rata-rata kelas meningkatkan menjadi 78,98 dengan persentase ketuntasan klasikal 86,36 % dan rata-rata aktivitas siswa meningkat menjadi 13,51 dengan persentase 75,05 %. Oleh karena itu, standar ketuntasan belajar klasikal yang ditetapkan yaitu 86% sudah tercapai. Berdasarkan analisa hasil penelitian tersebut penggunaan metode Kerja Kelompok ternyata mampu meningkatkan proses dan hasil belajar siswa.
Inferred family structure and dispersal patterns of a Critically Endangered species, Pinna nobilis, using molecular analyses: implications for conservation
Authors: Nebot-Colomer E , Vázquez-Luis M , Boissin E , Peyran C , Deudero S , Planes S
Published: August 2022

Knowledge of the genetic structure and dispersal patterns for keystone and vulnerable species is essential to the establishment of conservation strategies. Since autumn 2016, the Critically Endangered Pinna nobilis bivalve has suffered mass mortality events throughout the Mediterranean Sea, causing mortality of up to 100% in affected populations. To propose appropriate reintroduction programs for its recovery, the present study sought to determine the genetic structure and local dispersal patterns from a well-documented population of P. nobilis. Using 19 microsatellite markers, we obtained genotypic information for 771 individuals from 9 localities within Cabrera National Park (CNP). The CNP population of P. nobilis was a single and homogeneous population, with nearly half of the sampled individuals being related through 333 half-sib and 14 full-sib relationships. The siblings belonged to 126 different family clusters composed of 2-8 individuals recruited during several recruitment events from up to 4 different localities. No evidence was found to suggest that the population was self-sustaining, since no parent-offspring dyad was found. However, the fine-scale dispersal patterns observed in Santa Maria Bay highlight the importance of this locality for the sustainment of the population as a whole. These findings suggest that the CNP could be a good choice for future reintroduction programs. Future studies that compile data from this and other studies conducted in CNP should be considered when modeling for reintroduction.
Note on the Riemann Hypothesis: International Conference on Recent Developments in Mathematics (ICRDM 2022)
Authors: Vega Frank
Published: August 2022

The Riemann Hypothesis is a conjecture that the Riemann zeta function has its zeros only at the negative even integers and complex numbers with real part 1/2. In 1984, Guy Robin stated a new criterion for the Riemann Hypothesis. We prove the Riemann Hypothesis is true using the Robin's criterion.
3D bioprinting and Rigenera® micrografting technology: A possible countermeasure for wound healing in spaceflight
Authors: Aliberti Flaminia , Paolin Elisa , Benedetti Laura , Cusella Gabriella , Ceccarelli Gabriele
Published: August 2022

Plant and animal life forms have progressively developed mechanisms for perceiving and responding to gravity on Earth, where homeostatic mechanisms require feedback. Lack of gravity, as in the International Space Station (ISS), induces acute intra-generational changes in the quality of life. These include reduced bone calcium levels and muscle tone, provoking skin deterioration. All these problems reduce the work efficiency and quality of life of humans not only during exposure to microgravity (µG) but also after returning to Earth. This article discusses forthcoming experiments required under gravity and µG conditions to ensure effective and successful medical treatments for astronauts during long-term space missions, where healthcare is difficult and not guaranteed.
Genetic engineering for enhanced production of a novel alkaline protease BSP-1 in Bacillus amyloliquefaciens
Authors: Jiang Cong , Ye Changwen , Liu Yongfeng , Huang Kuo , Jiang Xuedeng , Zou Dian , Li Lu , Han Wenyuan , Wei Xuetuan
Published: August 2022

Alkaline protease has been widely applied in food, medicine, environmental protection and other industrial fields. However, the current activity and yield of alkaline protease cannot meet the demand. Therefore, it is important to identify new alkaline proteases with high activity. In this study, we cloned a potential alkaline protease gene bsp-1 from a Bacillus subtilis strain isolated in our laboratory. BSP-1 shows the highest sequence similarity to subtilisin NAT (S51909) from B. subtilis natto. Then, we expressed BSP-1 in Bacillus amyloliquefaciens BAX-9 and analyzed the protein expression level under a collection of promoters. The results show that the P43 promoter resulted in the highest transcription level, protein level and enzyme activity. Finally, we obtained a maximum activity of 524.12 U/mL using the P43 promoter after fermentation medium optimization. In conclusion, this study identified an alkaline protease gene bsp-1 from B. subtilis and provided a new method for high-efficiency alkaline protease expression in B. amyloliquefaciens.
Equilibrium path and stability analysis of rigid origami using energy minimization of frame model
Authors: Hayakawa Kentaro , Ohsaki Makoto
Published: August 2022

This paper presents a method of equilibrium path analysis and stability analysis of an equilibrium state for a rigid origami, which consists of rigid flat faces connected by straight crease lines (folding lines) and can be folded and unfolded without deformation of its faces. This property is well suited to the application to deployable structures and morphing building envelopes consisting of stiff panels. In this study, a frame model which consists of hinges and rigid frame members is used to model the kinematics of a rigid origami. Faces and crease lines of a rigid origami are represented by frame members and hinges, respectively. External loads are applied to the nodes of a frame model, and the displacements of some nodes are fixed. Small rotational stiffness proportional to the length of a crease line is assumed in each hinge to uniquely determine the equilibrium state, which is obtained by solving the optimization problem for minimizing the total potential energy under the conditions so that the displacements of the nodes and the members are compatible. The optimization problem is solved by the augmented Lagrangian method, and the positive definiteness of the Hessian of the augmented Lagrangian is investigated to determine the stability of the equilibrium state. Equilibrium path analyses are carried out and bifurcations of the equilibrium paths are investigated for examples with waterbomb patterns.
2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-Glucoside improves female ovarian aging
Authors: Lin Hung-Yun , Yang Yung-Ning , Chen Yi-Fong , Huang Tung-Yung , Crawford Dana R. , Chuang Hui-Yu , Chin Yu-Tang , Chu Hung-Ru , Li Zi-Lin , Shih Ya-Jung , Chen Yi-Ru , Yang Yu-Chen S. H. , Ho Yih , Davis Paul J. , Whang-Peng Jacqueline , Wang Kuan
Published: August 2022

Reduced fertility associated with normal aging may reflect the over-maturity of oocytes. It is increasingly important to reduce aging-induced infertility since recent trends show people marrying at later ages. 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside (THSG), a polyphenol extracted from Polygonum multiflorum, has been reported to have anti-inflammatory and anti-aging properties. To evaluate whether THSG can reduce aging-related ovarian damage in a female mouse model of aging, THSG was administered by gavage at a dose of 10 mg/kg twice weekly, starting at 4 weeks of age in a group of young mice. In addition, the effect of THSG in a group of aged mice was also studied in mice starting at 24 weeks of age. The number of oocytes in the THSG-fed group was higher than in the untreated control group. Although the percentage of secondary polar bodies (PB2) decreased during aging in the THSG-fed group, it decreased much more slowly than in the age-matched control group. THSG administration increased the quality of ovaries in young mice becoming aged. Western blotting analyses also indicated that CYP19, PR-B, and ER-β expressions were significantly increased in 36-week-old mice. THSG also increased oocyte numbers in aged mice compared to mice without THSG fed. Studies of qPCR and immunohistochemistry (IHC) analyses of ovaries in the aged mice groups were conducted. THSG increased gene expression of anti-Müllerian hormone (AMH), a biomarker of oocyte number, and protein accumulation in 40-week-old mice. THSG increased the expression of pgc1α and atp6, mitochondrial biogenesis-related genes, and their protein expression. THSG also attenuated the fading rate of CYP11a and CYP19 associated with sex hormone synthesis. And THSG maintains a high level of ER-β expression, thereby enhancing the sensitivity of estrogen. Our findings indicated that THSG increased or extended gene expression involved in ovarian maintenance and rejuvenation in young and aged mice. On the other hand, THSG treatments significantly maintained oocyte quantity and quality in both groups of young and aged mice compared to each age-matched control group. In conclusion, THSG can delay aging-related menopause, and the antioxidant properties of THSG may make it suitable for preventing aging-induced infertility.
A heterozygous p.S143P mutation in LMNA associates with proteasome dysfunction and enhanced autophagy-mediated degradation of mutant lamins A and C
Authors: West Gun , Turunen Minttu , Aalto Anna , Virtanen Laura , Li Song-Ping , Heliö Tiina , Meinander Annika , Taimen Pekka
Published: August 2022

Lamins A and C are nuclear intermediate filament proteins that form a proteinaceous meshwork called lamina beneath the inner nuclear membrane. Mutations in the LMNA gene encoding lamins A and C cause a heterogenous group of inherited degenerative diseases known as laminopathies. Previous studies have revealed altered cell signaling pathways in lamin-mutant patient cells, but little is known about the fate of mutant lamins A and C within the cells. Here, we analyzed the turnover of lamins A and C in cells derived from a dilated cardiomyopathy patient with a heterozygous p.S143P mutation in LMNA. We found that transcriptional activation and mRNA levels of LMNA are increased in the primary patient fibroblasts, but the protein levels of lamins A and C remain equal in control and patient cells because of a meticulous interplay between autophagy and the ubiquitin-proteasome system (UPS). Both endogenous and ectopic expression of p.S143P lamins A and C cause significantly reduced activity of UPS and an accumulation of K48-ubiquitin chains in the nucleus. Furthermore, K48-ubiquitinated lamins A and C are degraded by compensatory enhanced autophagy, as shown by increased autophagosome formation and binding of lamins A and C to microtubule-associated protein 1A/1B-light chain 3. Finally, chaperone 4-PBA augmented protein degradation by restoring UPS activity as well as autophagy in the patient cells. In summary, our results suggest that the p.S143P-mutant lamins A and C have overloading and deleterious effects on protein degradation machinery and pharmacological interventions with compounds enhancing protein degradation may be beneficial for cell homeostasis.
Fetal nuchal edema and developmental anomalies caused by gene mutations in mice
Authors: Sugiyama Akira , Hirashima Masanori
Published: August 2022

Fetal nuchal edema, a subcutaneous accumulation of extracellular fluid in the fetal neck, is detected as increased nuchal translucency (NT) by ultrasonography in the first trimester of pregnancy. It has been demonstrated that increased NT is associated with chromosomal anomalies and genetic syndromes accompanied with fetal malformations such as defective lymphatic vascular development, cardiac anomalies, anemia, and a wide range of other fetal anomalies. However, in many clinical cases of increased NT, causative genes, pathogenesis and prognosis have not been elucidated in humans. On the other hand, a large number of gene mutations have been reported to induce fetal nuchal edema in mouse models. Here, we review the relationship between the gene mutants causing fetal nuchal edema with defective lymphatic vascular development, cardiac anomalies, anemia and blood vascular endothelial barrier anomalies in mice. Moreover, we discuss how studies using gene mutant mouse models will be useful in developing diagnostic method and predicting prognosis.
Interaction between the nervous and skeletal systems
Authors: Xu Jiajia , Zhang Zhongmin , Zhao Junjie , Meyers Carolyn A. , Lee Seungyong , Qin Qizhi , James Aaron W.
Published: August 2022

The skeleton is one of the largest organ systems in the body and is richly innervated by the network of nerves. Peripheral nerves in the skeleton include sensory and sympathetic nerves. Crosstalk between bones and nerves is a hot topic of current research, yet it is not well understood. In this review, we will explore the role of nerves in bone repair and remodeling, as well as summarize the molecular mechanisms by which neurotransmitters regulate osteogenic differentiation. Furthermore, we discuss the skeleton’s role as an endocrine organ that regulates the innervation and function of nerves by secreting bone-derived factors. An understanding of the interactions between nerves and bone can help to prevent and treat bone diseases caused by abnormal innervation or nerve function, develop new strategies for clinical bone regeneration, and improve patient outcomes.
The SNARE protein Vti1b is recruited to the sites of BCR activation but is redundant for antigen internalisation, processing and presentation
Authors: Music Amna , Tejeda-González Blanca , Cunha Diogo M. , Fischer von Mollard Gabriele , Hernández-Pérez Sara , Mattila Pieta K.
Published: August 2022

In order to fulfil the special requirements of antigen-specific activation and communication with other immune cells, B lymphocytes require finely regulated endosomal vesicle trafficking. How the endosomal machinery is regulated in B cells remains largely unexplored. In our previous proximity proteomic screen, we identified the SNARE protein Vti1b as one of the strongest candidates getting accumulated to the sites of early BCR activation. In this report, we follow up on this finding and investigate the localisation and function of Vti1b in B cells. We found that GFP-fused Vti1b was concentrated at the Golgi complex, around the MTOC, as well as in the Rab7+ lysosomal vesicles in the cell periphery. Upon BCR activation with soluble antigen, Vti1b showed partial localization to the internalized antigen vesicles, especially in the periphery of the cell. Moreover, upon BCR activation using surface-bound antigen, Vti1b polarised to the immunological synapse, colocalising with the Golgi complex, and with lysosomes at actin foci. To test for a functional role of Vti1b in early B cell activation, we used primary B cells isolated from Vit1b-deficient mouse. However, we found no functional defects in BCR signalling, immunological synapse formation, or processing and presentation of the internalized antigen, suggesting that the loss of Vti1b in B cells could be compensated by its close homologue Vti1a or other SNAREs.
Calcium in peroxisomes: An essential messenger in an essential cell organelle
Authors: Sargsyan Yelena , Kalinowski Julia , Thoms Sven
Published: August 2022

Calcium is a central signal transduction element in biology. Peroxisomes are essential cellular organelles, yet calcium handling in peroxisomes has been contentious. Recent advances show that peroxisomes are part of calcium homeostasis in cardiac myocytes and therefore may contribute to or even shape their calcium-dependent functionality. However, the mechanisms of calcium movement between peroxisomes and other cellular sites and their mediators remain elusive. Here, we review calcium handling in peroxisomes in concert with other organelles and summarize the most recent knowledge on peroxisomal involvement in calcium dynamics with a focus on mammalian cells.
Electrochemical behavior of ionic and metallic zirconium in ionic liquids
Authors: Ashraf Muhammad Adeel , Valtiner Markus , Gavrilovic-Wohlmuther Aleksandra , Kampichler Juliane , Pichler Christian M.
Published: August 2022

Metallic zirconium has a broad range of potential applications in engineering and in industries that are operating under harsh corrosive environments, such as nuclear and chemical industry. Compared to other metals like aluminum, its behavior in electrochemical reactions is poorly understood and so far, there are no larger-scale electrochemical approaches to process zirconium. Ionic liquids are a suitable reaction medium for electrochemical reactions of zirconium. To better understand the electrochemical reactivity of zirconium, different combinations of ionic liquids and zirconium precursors are investigated. It was found that interactions between the Zr precursor and the ionic liquids can have significant influence on the diffusion properties of Zr. Furthermore, mixtures of ionic liquids with other solvents were explored and it could be determined that most of the electrochemical properties of Zr are retained also in solvent mixtures. This could potentially save costs for industrial applications, as lower amounts of the ionic liquids can be used, to obtain similar electrochemical properties.