bluuebunny/crossref_metadata_2025 huggingface dataset:
PENGARUH KUALITAS SUMBER DAYA MANUSIA, PEMANFAATAN TEKNOLOGI INFORMASI DAN PENGENDALIAN INTERN TERHADAP NILAI INFORMASI PELAPORAN KEUANGAN PEMERINTAH DAERAH
Authors: Riyadi Wulan , Fitriani Ani
Published: March 2022

Provinsi Jawa Barat merupakan daerah yang Laporan Keuangan Pemerintah Daerah (LKPD) nya selalu meraih tingkat opini Wajar Tanpa Pengecualian (WTP). Berdasarkan IHPS 1 Tahun 2013 Kabupaten Majalengka mendapatkan opini Wajar Dengan Pengecualian (WDP) pada tahun 2008-2012. Alasan BPK memberikan opini tersebut dikarenakan terdapat kelemahan pada sistem pengendalian akuntansi dan pelaporan keuangan. Namun, pada tahun 2013-2019 Kabupaten Majalengka mendapatkan opini Wajar Tanpa Pengecualian (WTP). Penelitian ini bertujuan untuk memperoleh bukti empiris tentang pengaruh kualitas sumber daya manusia, pemanfaatan teknologi informasi dan pengendalian intern terhadap nilai informasi pelaporan keuangan pemerintah daerah.

Metode yang digunakan dalam penelitian ini adalah metode survey dengan pendekatan analisis deskriptif dan analisis verifikatif. Teknik sampling yang digunakan adalah purposive sampling dengan teknik pengumpulan data menggunakan kuesioner. Responden dalam penelitian ini adalah Pejabat Penatausahaan Keuangan (PPK), Pejabat Pelaksana Teknis Kegiatan (PPTK) dan Bendahara pada Satuan Kerja Perangkat Daerah Kabupaten Majalengka yang berjumlah 84 orang. Pengujian instrumen penelitian dilakukan dengan uji validitas dan uji reliabilitas. Teknik analisis data menggunakan uji asumsi klasik, analisis regresi linear berganda, analisis koefisien determinasi, uji kelayakan model dan uji hipotesis dengan bantuan program SPSS versi 21.

Hasil penelitian ini menunjukkan bahwa kualitas sumber daya manusia berpengaruh signifikan terhadap nilai informasi pelaporan keuangan pemerintah daerah, pemanfaatan teknologi informasi berpengaruh signifikan terhadap nilai informasi pelaporan keuangan pemerintah daerah dan pengendalian intern berpengaruh signifikan terhadap nilai informasi pelaporan keuangan pemerintah daerah.
PENGARUH PERAN KEPEMIMPINAN DAN MOTIVASI TERHADAP DISIPLIN KERJA
Authors: Hernita Nita , Masduki
Published: March 2022

Study aims to determine how the influence of the role of leadership and motivation on work discipline in the study of KPH Perhutani Majalengka employees. This research is a type of quantitative research using a descriptive and verification approach.

The population in this study were all employees of KPH Perhutani Majalengka with a total sample of 65 respondents. The sampling technique used was the Saturated Sampling Technique with a total of 65 respondents and made the sample. The data collection technique in this study was a questionnaire using a Likert scale. Data analysis using classical assumption test, multiple regression analysis, coefficient of determination, model feasibility test and partial hypothesis testing.

The results showed that the role of leadership and motivation on work discipline was included in the high category. The results of the hypothesis test partially show that the role of leadership and motivation has a significant effect on work discipline
PENGARUH SISTEM PERPAJAKAN, DISKRIMINASI, TEKNOLOGI DAN INFORMASI PERPAJAKAN TERHADAP PERSEPSI WAJIB PAJAK MENGENAI PENGGELAPAN PAJAK
Authors: Aliyudin Rizal Sukma , Ahmad Eva Fauziah , Nizhan Nissa
Published: March 2022

This study aims to determine the effect of taxation systems, discrimination, technology and tax information on the perception of taxpayers at Majalengka University regarding tax evasion. The data used in this study are primary data. Primary data were obtained from questionnaires and measured using a Likert scale. The population used in this study is an individual taxpayer at Majalengka University. This sampling technique used saturated sampling with a sample of 280 respondents. The data analysis used descriptive analysis, verification analysis, classical assumption test, multiple linear regression analysis, determination coefficient analysis and hypothesis testing with the help of SPSS version 21.

The results showed that: (1) the taxation system had no significant effect on taxpayers' perceptions of tax evasion; (2) discrimination has a significant effect on taxpayers' perceptions of tax evasion; (3) technology and tax information do not have a significant effect on taxpayers' perceptions of tax evasion.
PENGARUH CORPORATE SOCIAL RESPONSIBILITY, UKURAN PERUSAHAAN DAN STRUKTUR MODAL TERHADAP EARNINGS RESPONSE COEFFICIENT
Authors: Maulana Robi , Rosliyani Resa
Published: March 2022

Kualitas laba penting bagi investor yang menggunakan laporan keuangan untuk tujuan kontrak dan pengambilan keputusan. penelitian ini bertujuan untuk mengetahui dan membuktikan secara empiris pengaruh corporate social responsibility, ukuran perusahaan dan struktur modal terhadap earnings response coefficient. Penelitian ini dilakukan pada perusahaan manufaktur sektor industri barang konsumsi yang terdaftar di Bursa Efek Indonesia pada tahun 2016-2019. Metode yang digunakan dalam penelitian ini adalah metode analisis deskriptif dan verifikatif. Pemilihan sampel dalam penelitian ini menggunakan metode purposive sampling dan sampel dari penelitian ini adalah sebanyak 27 perusahaan manufaktur sektor industri barang konsumsi yang terdaftar di Bursa Efek Indonesia (BEI). Teknik analisis yang digunakan dalam penelitian ini adalah analisis regresi linier berganda. Hasil penelitian ini menunjukkan bahwa corporate social responsibility tidak berpengaruh terhadap Earnings Response Coefficient. Ukuran perusahaan berpengaruh negative terhadap Earnings Response Coefficient. Struktur modal tidak berpengaruh terhadap Earnings Response Coefficient.
STRATEGI FUNDRAISING, MANAJEMEN PENGELOLAAN, DAN PENYALURAN DANA ZAKAT, INFAQ, DAN SHADAQAH PADA PANTI YAUMA MAJALENGKA
Authors: Lestari Ayu Gumilang , Idawati Neng Dewi
Published: March 2022

Sharia economics plays an important role in tackling poverty, including Zakat, Infaq and Shodaqoh which are potential sources of funds that can be utilized to realize people's welfare. In realizing the welfare of the people, Zakat, Infaq and Shodaqoh need an intermediary, namely an institution or foundation that manages and distributes Zakat, Infaq and Shodaqoh funds. A good Zakat, Infaq and Shodaqoh institution cannot be separated from the fundraising strategy, management management and distribution of trustworthy funds. The purpose of this study was to find out how the fundraising was carried out by the Yauma Majalengka Panti, how the management of Zakat, Infaq and Shodaqoh funds was carried out by the Yauma Majalengka Panti and how the distribution of Zakat, Infaq and Shodaqoh funds was carried out by the Yauma Majalengka Panti. This type of research is a field and library research using a descriptive qualitative approach. Data collection techniques in this study are: interviews, observation and documentation. Data sources consist of secondary data and primary data. by conducting interviews with several employees of Panti Yauma Majalengka and observing from existing data and from supporting data.

The results of the research study on the fundraising, management and distribution of Zakat Infaq and Shodaqoh funds at the Yauma Majalengka Orphanage have been carried out according to the planned program, namely the fundraising strategy using direct and indirect methods. The direct method is by: picking up care, charity boxes, pamphlets, close friends, online applications and social media, while fundarising indirectly through religious activities and seminars. The management of Zakat Infaq and Shodaqoh funds is carried out properly, the management system uses the PSAK 109 system, the distribution of Zakat Infaq and Shodaqoh funds is in accordance with fiqh, namely distributed to 8 groups (asnaf) in its distribution also has a program in each month, namely compensation for orphans and poor people, basic necessities, care for the elderly, scholarships and care for the Qur’an teacher.
PENGARUH INOVASI PRODUK DAN BRAND IMAGE TERHADAP MINAT BELI
Authors: Istiono Deni , Kurniasih Nining
Published: March 2022

This study aims to determine how the influence of Product Innovation and Brand Image on Buying Interest in Wild Original in Majalengka City. This research is a survey research research using descriptive and verification approaches.

The population in this study were Wild Original consumers in Majalengka City with a total sample of 100 respondents. The sampling technique used was Nonprobability Sampling. The data collection technique in this study was a questionnaire using a Likert scale. Data analysis using classical assumption test, multiple regression analysis, coefficient of determination, model feasibility test and partial hypothesis testing.

The results showed that Product Innovation was in a good category and Brand Image was in a good category. Hypothesis test results show partially that Product Innovation has a positive and significant effect on Purchase Intention. Brand Image has a positive and significant effect on Purchase Interest.
ANALISIS PENDAPATAN ASLI DAERAH KABUPATEN MAJALENGKA BERDASARKAN PAJAK HIBURAN, PAJAK RESTORAN DAN PAJAK HOTEL
Authors: Sri Mulyani Hani , Dasuki Tito Marta Sugema , Amnah Nani
Published: March 2022

Pendapatan asli daerah merupakan sumber penerimaan daerah yang digali dari wilayah daerah yang bersangkutan terdiri dari hasil pajak daerah, retribusi daerah, pengelolaan kekayaan daerah yang dipisahkan dan pendapatan lain-lain yang sah. Pendapatan asli daerah Kabupaten Majalengka masih belum stabil, dilihat dari penerimaan pajak hiburan, pajak restoran dan pajak hotel yang mengalami fluktuasi pada realisasinya. Maka dari itu tujuan penelitian ini untuk mengetahui secara parsial pengaruh pajak hiburan, pajak restoran dan pajak hotel terhadap pendapatan asli daerah Kabupaten Majalengka periode 2017-2020.

Pendekatan penelitian yang digunakan dalam penelitian ini adalah analisis deskriptif dan verifikatif dengan menggunakan data sekunder. Populasi dalam penelitian ini adalah Laporan Realisasi Pendapatan Asli Daerah khususnya pajak hiburan, pajak restoran dan pajak hotel Kabupaten Majalengka periode 2017- 2020. Sedangkan sampel dalam penelitian ini adalah ditentukan dengan menggunakan metode sampling sensus atau sampling jenuh sehingga diperoleh 48 sampel dari bulan Januari 2017 – Desember 2020. Metode analisis yang digunakan dalam penelitian ini adalah analisis regresi linier berganda yang dilakukan dengan bantuan software SPSS 21.

Berdasarkan penelitian yang telah dilakukan maka diperoleh hasil bahwa secara parsial pajak hiburan, pajak restoran dan pajak hotel berpengaruh terhadap pendapatan asli daerah.
PENGARUH PENGHARGAAN INTRINSIK DAN PENGHARGAAN EKSTRINSIK TERHADAP KEPUASAN KERJA KARYAWAN PERUMDA BPR PUSAT MAJALENGKA
Authors: Hernita Nita
Published: March 2022

Research was conducted on employees of  Perumda BPR Pusat Majalengka. Target of this research is to identify intrinsic rewards and extrinsic rewards to employee job satisfaction, and how much influence the intrinsic rewards and extrinsic rewards to employee  job satisfaction.

The method used is by using descriptive analysis and verification techniques. The sample is this study were 45 peoples using saturated sampling techniques. Data collection are the questionnaires. Testing is done with the data instrument validity and reliability testing, while data anlysis is a classic assumption test, multiple regression test, determination, and hypothesis testing with SPSS 21 Version.

Based on research results to the variable intrinsic rewards, extrinsic rewards, and employee  job satisfaction variables included in the high category. Furthermore, based on verifikatif analysis of intrinsics rewards and extrinsics rewards have a positive and significant impact on employee job satisfaction either partially or simultaneously
PENGARUH LIKUIDITAS DAN LEVERAGE TERHADAP PROFITABILITAS PADA PERUSAHAAN MAKANAN SERTA MINUMAN YANG TERDAFTAR DI BEI TAHUN 2016-2020
Authors: Dewi Salma Mellisa , Manda Gusganda Suria
Published: March 2022

Profitabilitas ialah salah satu tolak ukur untuk menilai kinerja keuangan perusahaan. Tujuan dari riset ini ialah untuk mengetahui apakah ada pengaruh likuiditas serta leverage terhadap profitabilitas. Data dalam riset ini diambil dari laporan tahunan masing-masing perusahaan selama tahun 2016-2020. Pengambilan sampel memakai purposive sampel dengan beberapa kriteria tertentu sehingga menghasilkan 7 perusahaan dengan periode pengamatan selama 5 tahun sehingga diperoleh 35 data. Teknik analisis yang dipakai pada riset ini ialah analisis regresi berganda serta uji hipotesis. Hasil riset ini menunjukkan bahwa variabel likuiditas mempengaruhi profitabilitas sesedangkan leverage tidak mempengaruhi profitabilitas
PENGARUH DANA ALOKASI UMUM, DANA ALOKASI KHUSUS DAN BELANJA MODAL TERHADAP TINGKAT KEMANDIRIAN KEUANGAN DAERAH PADA KABUPATEN/KOTA DI PROVINSI JAWA BARAT
Authors: Riyadi Wulan
Published: March 2022

Provinsi Jawa Barat Terdapat beberapa kabupaten/kota yang kemandirian keuangan daerahnya masih rendah. Tujuan penelitian ini adalah untuk mengetahui bagaimana pengaruh dana alokasi umum, dana alokasi khusus dan belanja modal pada tingkat kemandirian keuangan daerah.

Metode penelitian yang digunakan adalah metode analisis deskriptif dan verifikatif. Populasi dalam penelitian ini adalah kabupaten/kota di Provinsi Jawa Barat yang berjumlah 27 kabupaten/kota, dan seluruhnya dijadikan sebagai sampel penelitian. Penelitian ini menggunakan analisis regresi linear berganda dan analisis koefisien determinasi dan uji hipotesis.

Hasil penelitian ini yaitu dana alokasi umum tidak berpengaruh signifikan terhadap tingkat kemandirian keuangan daerah. Sedangkan untuk Dana alokasi khusus dan Belanja modal berpengaruh signifikan terhadap tingkat kemandirian keuangan daerah
PENGARUH PERTUMBUHAN PERUSAHAAN, UKURAN PERUSAHAAN, STRUKTUR MODAL DAN RETURN ON ASSETS TERHADAP KEBIJAKAN DIVIDEN
Authors: Ginanjar Yogi
Published: March 2022

Kebijakan dividen merupakan suatu kebijakan perusahaan apakah laba yang diperoleh akan dibagikan kepada pemegang saham berupa dividen atau disimpan sebagai laba ditahan untuk investasi di masa yang akan datang. Pada perusahaan sektor industri barang konsumsi masih terdapat perusahaan yang tidak membagikan dividen secara konsisten. Tujuan dari penelitian ini yaitu untuk mengetahui bagaimana pengaruh pertumbuhan perusahaan, ukuran perusahaan, struktur modal, dan return on assets terhadap kebijakan dividen pada perusahaan sektor industri barang konsumsi yang terdaftar di Bursa Efek Indonesia tahun 2016-2020.

Populasi dalam penelitian ini adalah perusahaan sektor industri barang konsumsi yang terdaftar di Bursa Efek Indonesia tahun 2016-2020 dengan total sebanyak 55 perusahaan. Pemilihan sampel dalam penelitian ini menggunakan metode purposive sampling, artinya sampel diambil dengan kriteria tertentu sehingga diperoleh sampel sebanyak 14 perusahaan maka jumlah data yang di observasi tahun 2016-2020 diperoleh 70 data. Rancangan analisis data menggunakan analisis deskriptif dan verifikatif meliputi uji asumsi klasik, analisis regresi linier berganda, analisis koefisien determinasi, uji kelayakan model, dan uji hipotesis secara parsial (uji t).

Hasil dalam penelitian ini menunjukan bahwa pertumbuhan perusahaan tidak berpengaruh terhadap kebijakan dividen. Ukuran perusahaan berpengaruh terhadap kebijakan dividen. Struktur modal berpengaruh terhadap kebijakan dividen, dan Return on Assets (ROA) berpengaruh terhadap kebijakan dividen
Acetylsalicylic acid to prevent preeclampsia and its complications. State-of-the-art of risk groups
Authors:   Pirogov Russian National Research Medical University, Moscow, Russian Federation, Kuznetsov P.A. ,   Branch of the City Clinical Hospital No. 24 — Perinatal Center, Moscow, Russian Federation, Dzhokhadze L.S. ,   Pirogov Russian National Research Medical University, Moscow, Russian Federation,   Branch of the City Clinical Hospital No. 24 — Perinatal Center, Moscow, Russian Federation, Shamugiya V.V. ,   Branch of the V.V. Veresaev City Clinical Hospital, Moscow, Russian Federation, Kravtsova O.M. ,   Pirogov Russian National Research Medical University, Moscow, Russian Federation, Dobrokhotova Yu.E. ,   Pirogov Russian National Research Medical University, Moscow, Russian Federation
Published: March 2022

This paper reviews current published data on the use of acetylsalicylic acid (ASA) for preventing preeclampsia and its complications and techniques to determine risk groups for im-plementing this preventive treatment. In addition, the authors summarize data on the history of ASA advent and introduction into medical practice (particularly obstetrics) and presumed mech-anisms of its action as first-line therapy to prevent preeclampsia. Recent review papers and guidelines addressing optimal ASA dose, treatment duration, and dosing during pregnancy in Russia and worldwide are discussed. Methods that have been studied as preventive ones for preeclampsia are briefly discussed. It was demonstrated that anamnestic determination of risk groups of early preeclampsia is not always enough. Expanded combined first-trimester screening is a perspective diagnostic tool. Success in determining high-risk groups and optimal prevention of preeclampsia may significantly affect population health by reducing maternal and perinatal mortality and long-term risk of cardiovascular events both in the mother and child. KEYWORDS: preeclampsia, acetylsalicylic acid, screening, placental disorders, trophoblast, fetal growth restriction, prevention of preeclampsia, uterine artery pulsatility index, pregnancy-associated plasma protein A (PAPP-A), placental growth factor (PlGF). FOR CITATION: Kuznetsov P.A., Dzhokhadze L.S., Shamugiya V.V., Kravtsova O.M. Acetylsalicylic acid to prevent preeclampsia and its complications. State-of-the-art of risk groups. Russian Journal of Woman and Child Health. 2022;5(1):28–34 (in Russ.). DOI: 10.32364/2618-8430-2022-5-1-28-34.
State-of-the-art therapy for salpingo-oophoritis from the perspective of novel clinical guidelines
Authors:   Volgograd State Medical University, Volgograd, Russian Federation, Selikhova M.S. , Smol’yaninov A.A. ,   Volgograd State Medical University, Volgograd, Russian Federation
Published: March 2022

Pelvic inflammatory disease (PID) is an important issue due to its high occurrence in women of reproductive age and adverse effects on reproductive function. In 2021, the Ministry of Health of the Russian Federation had approved clinical guidelines that standardized management and treatment approaches to PID. These novel clinical guidelines focus on rational outpatient antimicrobial therapy using broad-spectrum medications. Treatment is prescribed empirically considering the predominant polymicrobial nature of PID. Opportunistic microbes (i.e., obligatory and facultative anaerobes) increasingly become causative agents of PID. Low titers of these microbes are found in the normal vaginal microflora, favoring broad-spectrum antibiotics effective against gram-positive and gram-negative bacteria. Treatment duration should be at least 10–14 days to completely eradicate the pathogen and prevent chronicity. Attention should be focused on choosing antibiotics with favorable safety profiles. KEYWORDS: pelvic inflammatory disease, clinical guidelines, outpatient treatment, antibiotics, doxycycline, dispersible tablet, adherence. FOR CITATION: Selikhova M.S., Smol’yaninov A.A. State-of-the-art therapy for salpingo-oophoritis from the perspective of novel clinical guidelines. Russian Journal of Woman and Child Health. 2022;5(1):35–40 (in Russ.). DOI: 10.32364/2618-8430-2022-5-1-35-40.
Female intimate hygiene is a relevant addition to prevent vulvovaginitis
Authors:   A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, Russian Federation, Manukhin I.B. , Manukhina E.I. ,   A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, Russian Federation, Safaryan I.R. ,   A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, Russian Federation, Ovakimyan M.A. ,   A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, Russian Federation
Published: March 2022

Pelvic inflammatory disease (PID) ranks first among gynecological disorders. Establishing intimate health prevents inflammatory diseases of the female reproductive system. Obstetricians and gynecologists are significantly responsible for maintaining intimate health and developing personal hygiene practices. This paper highlights intimate female health. The authors describe personal hygiene practices and intimate ethics in women of reproductive age. These habits are essential for preventing vaginal infections. Patient education contributes to the development of hygiene practices and helps take responsibility for reproductive health. Intimate hygiene maintains the healthy mucosal barrier required for normal reproductive function and prevents vaginal infections. Specific products maintaining normal pH and natural vaginal microflora (e.g., natural lactic acid-based) are recommended for intimate hygiene. Lactic acid favors the growth of Lactobacilli so that its gel can be used to prevent vaginal dysbiosis. The balanced composition provides effective hygiene of the intimate area and prevents vaginal infections. Daily use of gel is the key to intimate female health. KEYWORDS: female health, intimate hygiene, vaginal infections, vaginal microflora, lactic acid, vaginal pH, chlorohexidin, intimate hygiene gel. FOR CITATION: Manukhin I.B., Manukhina E.I., Safaryan I.R., Ovakimyan M.A. Female intimate hygiene is a relevant addition to prevent vulvovaginitis. Russian Journal of Woman and Child Health. 2022;5(1):46–50 (in Russ.). DOI: 10.32364/2618-8430-2022-5-1-46-50.
HLA class II alleles in couples with failed ART attempts
Authors:   KRIHBT, Kirov, Russian Federation, Zagarskikh A.N. , Butina E.V. ,   KRIHBT, Kirov, Russian Federation, Zaytseva G.A. ,   KRIHBT, Kirov, Russian Federation
Published: March 2022

Aim: to study immunogenetic patterns of couples who have appealed to assisted reproductive technologies (ARTs). Patients and Methods: HLA class II typing was performed in 345 couples with different outcomes of ARTs, i.e., ineffective in vitro fertilization (IVF) or intrauterine insemination (IUI), and missed miscarriage after IVF. Inclusion criteria were primary or secondary ART implantation failures. HLA class II typing was performed by real-time PCR. In addition, HLA genotypes were investigated in women examined for female infertility (ICD-10 cone N97) and men examined for urogenital infections plus spermogram, MAR test, and assessment of AZF deletions. All participants were divided into five groups of pairs based on obstetric and gynecologic history, i.e., one failed IVF attempt (n=100), two failed IVF attempts (n=64), three or more failed IVF attempts (n=87), ineffective IUI (n=48), and missed miscarriage after IVF (n=10). The comparision group included 36 couples with one or more childbirths after ARTs. Results: ART efficacy depends on the HLA genotypes of couples. In women, DQA1*01:02 is associated with IVF failure. In men, DQA1*01:01 is associated with failed ART, and DQA1*05:01 is associated with childbirth after ARTs. In men, DRB1*11 favors effective IUI. DQB1*03:03 in women and DRB1*01, DQA1*01:01, and DQB1*05:01 in men predispose to missed miscarriages after IVF and IUI. In men, DQB1*02:01 contributes to childbirths after ARTs. The outcomes of IVF and IUI are not related to husband-wife matching for HLA class II alleles. Conclusion: HLA class II typing is crucial for diagnosing infertility when using assisted reproductive technologies. KEYWORDS: infertility, in vitro fertilization, alleles, genes, HLA. FOR CITATION: Zagarskikh A.N., Butina E.V., Zaytseva G.A. HLA class II alleles in couples with failed ART attempts. Russian Journal of Woman and Child Health. 2022;5(1):5–10 (in Russ.). DOI: 10.32364/2618-8430-2022-5-1-5-10.
Cardiac and non-cardiac manifestations of infection caused by group A β-hemolytic Streptococcus
Authors:   Samara State Medical University, Samara, Russian Federation, Santalova G.V. , Lebedev P.A. ,   Samara State Medical University, Samara, Russian Federation, Garanin A.A. ,   Samara State Medical University, Samara, Russian Federation, Lyamin A.V. ,   Samara State Medical University, Samara, Russian Federation, Kuzin M.E. ,   Samara State Medical University, Samara, Russian Federation
Published: March 2022

Infection caused by group A β-hemolytic Streptococcus (GABHS) is characterized by significant diversity of clinical presentations accounted for by different GABHS strains and individual patients’ predisposition to immune inflammation. This paper reviews current data on streptococcal infection and poststreptococcal cardiac and non-cardiac complications and describes early diagnostic tools. Superficial infections are the most common forms (particularly in pediatrics) manifested as pharyngitis, tonsillitis, otitis, or sinusitis. Invasive infections (pneumonia, necrotizing fasciitis) are potentially lethal conditions accompanied by bacteremia and generalized inflammation. Strains producing exotoxins (GABHS superantigens) provoke scarlet fever and streptococcal toxic shock syndrome. The primary burden of cardiac complications of GABHS infections is still chronic rheumatic heart disease resulting from undiagnosed and untreated acute rheumatic fever. Valvulitis underlying cardiac complications have a subclinical course, requiring echocardiography to establish the diagnosis. Antibacterial treatment with β-lactam antibiotics as a first-line treatment for GABHS infection and prevention of cardiac and non-cardiac complications increase the relevance of early etiological diagnosis. These tools are clinical syndrome scale, culture, and rapid diagnostic tests based on streptococcal DNA and antigen detection. KEYWORDS: group A β-hemolytic Streptococcus, manifestations and complications of streptococcal infections, acute rheumatic fever, chronic rheumatic heart disease. FOR CITATION: Santalova G.V., Lebedev P.A., Garanin A.A. et al. Cardiac and non-cardiac manifestations of infection caused bygroup A β-hemolytic Streptococcus. Russian Journal of Woman and Child Health. 2022;5(1):63–71 (in Russ.). DOI: 10.32364/2618-8430-2022-5-1-63-71.
One strain of L. reuteri implies many options. Important issues in pediatrics
Authors:   Central Research Institute of Epidemiology of the Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russian Federation, Nikolaeva S.V. , Kanner E.V. ,   Central Research Institute of Epidemiology of the Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russian Federation, Shushakova E.K. ,   Central Research Institute of Epidemiology of the Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russian Federation, Ploskireva A.A. ,   Central Research Institute of Epidemiology of the Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russian Federation,   Pirogov Russian National Research Medical University, Moscow, Russian Federation
Published: March 2022

Probiotics are living organisms that favor human health if administered in adequate amounts. In recent years, mechanisms of action of probiotics have been described. Moreover, strong evidence of their efficacy for preventing intestinal and respiratory infections, managing allergic and gastrointestinal disorders, and other pathologic conditions in children of different years was retrieved. Complex, physiological effects probiotics (if microbial strains are to be carefully selected and monitored for safety) contributed to the emergence of many probiotic preparations on the market. Lactobacillus reuteri, a well-known species of Lactobacillus, modulates immune response modulation, prevents infections and diseases, and is beneficial to human health. This paper addresses critical evidence of the efficacy of L. reuteri in children. Numerous clinical studies established its safety and tolerability. L. reuteri is effective for preventing and treating many diseases, including infantile colic, diarrhea, functional abdominal pain, atopic dermatitis, and allergy. L. reuteri is considered one of the available and effective medications for colic and other functional gastrointestinal disorders in children. KEYWORDS: children, probiotics, Lactobacillus reuteri, infantile colic, diarrhea, atopic dermatitis, allergy. FOR CITATION: Nikolaeva S.V., Kanner E.V., Shushakova E.K., Ploskireva A.A. One strain of L. reuteri implies many options. Important issues in pediatrics. Russian Journal of Woman and Child Health. 2022;5(1):72–77 (in Russ.). DOI: 10.32364/2618-8430-2022-5-1-72-77.
Role of fat malabsorption during breastfeeding in late hemorrhagic disease of the newborn
Authors:   Yaroslavl State Medical University, Yaroslavl, Russian Federation, Mozzhukhina L.I. , Kalgina S.E. ,   Yaroslavl State Medical University, Yaroslavl, Russian Federation, Stroeva L.E. ,   Yaroslavl State Medical University, Yaroslavl, Russian Federation, Teyf V.A. ,   Regional Children’s City Hospital, Yaroslavl, Russian Federation
Published: March 2022

The causes of late hemorrhagic disease of the newborn (HDN) are parenteral nutrition, severe diseases (e.g., biliary atresia, congenital or inherited diseases associated with cholestasis, short bowel syndrome), exclusive breastfeeding, and digestive disorders with malabsorption. Meanwhile, vitamin K deficiency develops in severe malabsorption and digestive disorders resulting from an irrational diet of a nursing mother or viral infections with the intestinal syndrome. Lipidogram of feces was evaluated by thin-layer chromatography in 15 children with late HDN. Lipidogram demonstrated high lipid content (on average, 77.47 μg/g). Moreover, the maximum levels of higher fatty acids, cholesterol, and phospholipids were detected in children with the most severe clinical presentations of bleeding. Clinical manifestations of hemorrhagic syndrome included umbilical cord bleeding (66.7%), gastrointestinal bleeding (28.5%), and intracranial hemorrhage (6.7%). In addition, all children have one or more clinical symptoms of digestive disorders (i.e., frequent bowel movements, excessive pooping, watery diarrhea). Occasionally, bloody streaks were reported. Education of nursing mothers to plan their diet and follow a balanced diet demonstrates that strict adherence to these recommendations significantly reduces the risks of vitamin K deficiency in newborns and late HDN. KEYWORDS: vitamin K, vitamin K deficiency bleeding, breastfeeding, children, lipidogram of feces, late hemorrhagic disease of the newborn, malabsorption. FOR CITATION: Mozzhukhina L.I., Kalgina S.E., Stroeva L.E., Teyf V.A. Role of fat malabsorption during breastfeeding in late hemorrhagic disease of the newborn. Russian Journal of Woman and Child Health. 2022;5(1):85–89 (in Russ.). DOI: 10.32364/2618- 8430-2022-5-1-85-89
Worster-Drought syndrome. Neurological pattern (case report)
Authors:   Children’s City Hospital No. 1, St. Petersburg, Russian Federation, Shchugareva L.M. ,   I.I. Mechnikov North-Western State Medical University St. Petersburg, Russian Federation, Poteshkina O.V. ,   Children’s City Hospital No. 1, St. Petersburg, Russian Federation,   I.I. Mechnikov North-Western State Medical University St. Petersburg, Russian Federation, Petrova V.D. ,   I.I. Mechnikov North-Western State Medical University St. Petersburg, Russian Federation, Salamanov P.A. ,   I.I. Mechnikov North-Western State Medical University St. Petersburg, Russian Federation
Published: March 2022

Worster-Drought syndrome (WDS) is a rare neurological disorder characterized by dissociation of voluntary and involuntary movements of the face, mouth, tongue, dysarthria, and oromotor dyspraxia. WDS rate varies from 1–9 per 100,000 to 1 per 25,000–30,000 newborns. Anterior (frontal) operculum, including the lower Rolandic area. WDS is diagnosed in the neonatal period based on a typical phenotype and neuroimaging findings. The prognosis is determined by medical care, epilepsy management, and rehabilitation. We describe a child with a severe WDS phenotype. In this child, abnormal intrauterine neuronal migration was associated with established cytomegalovirus meningoencephalitis in the neonatal period. Moreover, phenotypic signs (dissociation of voluntary and involuntary movements, dysarthria, severe salivation, microcephaly, and epilepsy) were coupled with neuroimaging findings (bilateral polymicrogyria of the opercular area and microcephalia). Pediatricians should be aware of WDS clinical polymorphism. The knowledge base is upgraded annually. KEYWORDS: Worster-Drought syndrome, congenital pseudobulbar palsy, seizures, dysarthria, developmental delay, microcephalia, polymicrogyria. FOR CITATION: Shchugareva L.M., Poteshkina O.V., Petrova V.D., Salamanov P.A. Worster-Drought syndrome. Neurological pattern (case report). Russian Journal of Woman and Child Health. 2022;5(1):90–96 (in Russ.). DOI: 10.32364/2618-8430-2022-5-1-90-96.
Violencia, Educación y Teoría Mimética. Hacia una mímesis positiva
Authors: Oñate Cantero María Araceli
Published: March 2022

Comprender la complejidad del acoso y la violencia escolar constituye un paso previo necesario a la propuesta de cualquier modelo de prevención cuya eficacia se postule y cuyo fundamento sea la centralidad de la persona y la búsqueda de la verdad en el ámbito educativo, lugar privilegiado de encuentro. La Teoría Mimética descrita por Girard no sólo explica las raíces de la violencia presente en las aulas, sino que constituye su fundamento antropológico y el marco teórico adecuado para revertirla, además de reconocer en la víctima inocente la piedra angular del edificio de la educación.

Las exigencias internacionales, las reformas del Código penal y de los mecanismos de protección a la infancia recuerdan, a instituciones públicas y privadas, la responsabilidad de garantizar un entorno seguro a todos y cada uno de sus escolares. Compromiso de toda la Comunidad educativa, aprobación de Protocolos de Buen Trato por parte de los alumnos, identificación precoz mediante la evaluación periódica de la violencia, gestión de las actitudes en el aula y mentorías de evolución psicosocial; triple mirada institucional, psicosocial e individual del Programa AVE de Prevención de la Violencia y el Acoso Escolar que, a partir de las aportaciones de René Girard y Jean Chistian Fauvet, viene demostrando su eficacia al servicio de la erradicación del acoso escolar y la discriminación de nuestras aulas.
Energy Demand Modeling for the Eastern Economic Corridor of Thailand: A Case Study of Rayong Province
Authors: Tippichai Atit , Lunsamrong Chanidaporn
Published: March 2022

This paper assesses long-term energy consumption and greenhouse gas (GHG) emissions in Rayong Province which is one of the three provinces in the Eastern Economic Corridor (EEC) of Thailand. LEAP (the Low Emissions Analysis Platform) is used to project final energy demand for each economic sector by using the 2019 data as a base year. In the model, we defined the energy consumption into two scenarios; a business-as-usual (BAU) scenario and a low carbon scenario (LCS), to see different energy demand and CO2 emissions up to the year 2050. There are different assumptions between BAU and LCS in each sector such as energy efficiency improvement, shift to modern energy, the share of high energy-efficient vehicles, etc. In the BAU scenario, the final energy consumption needed by Rayong Province will increase with an average annual growth rate (AAGR) of 3.49%, while only 1.52% for the LCS. CO2 emissions in the LCS will be reduced by 41.7% by 2050 when compared with the BAU scenario. Most interestingly, even though energy demand in Rayong Province will be increasing up to 2050, CO2 emissions will peak about 2035 and then reduce. The industry and transport sectors are the most final energy consumption and the highest CO2 emissions. This is because EEC is driven by a production-based economy. The solution for this is to transform to alternative energies sourcing, shift all productions to sustainable ones, restructure the industrial estate to become the eco-industrial and GHG emissions management, which will also result in obvious carbon reduction. This kind of information will be beneficial to energy demand conservation and GHG emission mitigation at the provincial level which will depend on the energy policies initiated and implemented in the future.
Anesthetic Management with Dexmedetomidine During the Awake Craniotomy Surgery: A Case Report
Authors: Uzun Şennur , İzgi Murat , Rasulova Turana
Published: March 2022

Objective: Awake craniotomy is a procedure of choice when the area to be resected is close to the eloquent regions of the cerebral cortex. In this case report, the anesthetic technique in the awake craniotomy case presented.

Case Presentation: A 62 years old female was scheduled for awake craniotomy procedure. Anatomically, the tumor involved the motor tracts of the right hand. Following the intravenous access and monitorization of the patient, 4.5 mg midazolam and 50 mcg of fentanyl used for sedation of the patient and dexmedetomidine was used for maintenance. We used Bispectral Electroencephalogram Index in order to measure the deepness of sedation during the surgery. Desaturation and hypercapnia on the arterial blood gas analysis seen following the addition of 3 mg of midazolam to deeper the sedation after hemostasis. The dose of dexmedetomidine increased and flumazenil administered to reverse the midazolam.

Discussion: Dexmedetomidine belongs to alpha-2 adrenergic agonist group, which acts through its sedative effects at the locus coeruleus. Different from GABA, alpha-2 adrenoreceptors produce sedation without the entire spectrum of stupor letting patients stay somnolent and easily awakened with verbal stimuli becoming compatible to be tested. In conclusion, dexmedetomidine is one of the possible choices of medication for awake craniotomy as it maintains the patient’s convenience, reduces analgesic needs, and level of deliberateness without any confusion and agitation.
CRISPR-based Approaches for the Point-of-Care Diagnosis of COVID19
Authors: Uzay İhsan Alp , Dinçer Pervin
Published: March 2022

Severe acute respiratory syndrome coronavirus -2 (SARS-CoV-2), is a novel Betacoronavirus variant that emerged in December 2019 causing the coronavirus disease 19 (COVID19) pandemic. It is reported that asymptomatic and presymptomatic individuals can transmit the virus and this silent transmission has been a major obstacle for the control of the pandemic. To overcome this obstacle, widespread testing with a rapid turnaround time is required. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) is currently the golden standard for the diagnosis of COVID19 worldwide. Even though RT-qPCR is an efficient method in terms of sensitivity and specificity, the need for elaborate instrumentation and skilled personnel restricts its widespread use. Restriction of RT-qPCR to a limited number of laboratories makes it further time-consuming. Many approaches are present to address the requirement for a rapid and accurate COVID19 diagnosis. In this review, different CRISPR-based approaches for the point-of-care diagnosis of COVID19 are compared. Among these approaches, CRISPR-FDS on-chip assay is found to be the best option as it is reported to be highly sensitive and specific, has a short turnaround time (15 min), does not need RNA isolation or special tools, and simple to perform. In terms of clinical validation, SHERLOCK, STOPCovid, and DETECTR were the most extensively studied ones and they are also reported to be highly sensitive and specific compared to RT-qPCR.
Investigation of Mean Platelet Volume as a Prognostic Criterion in Non-Healing Wounds
Authors: Tutak Fatma Nilay , Doğan Fatih , Vural Aşkı
Published: March 2022

Objective: We aimed to evaluate if the Mean Platelet Volume (MPV) is an acute phase reactant in non-healing wounds, by analyzing its correlation with Erythrocyte Sedimentation Rate (ESR).

Method: Our study was carried out in a descriptive type with the participation of patients with non-healing wounds. The laboratory data and characteristics of the patients were accessed retrospectively, and the obtained data were recorded in the data recording form.

Results: The sample group consisted of 92 patients with non-healing wounds. 26.9% of the patients with non-healing wounds had pressure sores, 37.6% of them had diabetic foot wounds, 18.3% had non-healing wounds developed after trauma, and 17.2% had necrotizing fasciitis. The average age of the patients was 53.22±19.13, and the average length of stay in the hospital was 108.98±18.78 (min 3 months, max 6 months) days. The MPV value, which was found to be high in the early stages of non-healing wounds, decreased after the wound was completely healed. When the MPV value was compared to ESR, an acute phase reactant, a positive and strong statistically significant correlation was found between MPV and ESR based on the result of this correlation analysis (r=0.256, p<0.01).

Conclusion: MPV can be used as a marker, just like ESR, in the presence of non-healing wounds. MPV value can be measured with blood taken into the complete blood count. However, an extra blood sample and a different tube are required for ESR. Using MPV value instead of ESR will provide savings in terms of cost and labor.
The Factors Related to the 6 Minute Walk Test: The Experience of a Referral Lung Transplantation Center
Authors: Atagün Güney Pınar
Published: March 2022

Objectives: The 6-minute-walk test is a practical and widely used test, which indicates the exercise capacity in patients with a severe pulmonary disease. The study aims to investigate the related factors with the 6-minute-walk test in lung transplantation candidates.

Materials and Method: The data were collected retrospectively from 349 patients, between January 2012 and September 2020. The patients were grouped according to their underlying lung disease as obstructive lung diseases, interstitial lung diseases, and infective lung diseases. The data collected included patient demographics, gender, body mass index, artery blood gas, the results of the respiratory function test, six-minute walk test, long-term oxygen therapy, and the need for non-invasive mechanical ventilation [such as group 1 (6MWD<200) and group 2(6MWD≥200)]. All of the collected data were analyzed and compared between the groups.

Results: Overall, 349 patients were included in the study, and there were 123 females and 226 males (35.2% and 64.8% respectively) with a mean age of 46.92 ± 14.1 years. Their mean body mass index was 23.58 ± 12.52 kg/m2, the median FEV1(%) was 35.3 (33.4-37.2), the median six-minute walk distance was 222 m (125-335 m), and the mean PaO2/FiO2 (P/F) was 250.32% ± 74.81, the mean PCO2 was 45.71 mmHg ± 11.97. Furthermore, the patients using long-term oxygen therapy were (n=274, 78.5%) and non-invasive mechanical ventilation were (n=125, 35.8%). The mortality status, P/F, long-term oxygen therapy usage, and non-invasive mechanical ventilation usage were different between Group 1 and Group 2 (p=0.001, p=0.001, p<0.001, and p<0.001, respectively). There was no difference between the groups in patients with and without IPF between underlying diseases. The 6-minute walk test was found to have moderate correlation with FEV1 and P/F; and a negative correlation with age and PCO2 (p<0.01, r=0.33.8, p<0.001, r= 38.1 and p=0.17, r=12,7, p<0.001, r=-0.30.6, respectively). There was no correlation between P/F, FEV1, and body mass index; and also, between PCO2, age, and body mass index. Age had a weak correlation with FEV1(p<0.001, r=19.3). There was no correlation between the age and 6MWD, as well as P/F, PCO2, and the body mass index. The factors affecting survival in multivariate analysis were investigated by using the Cox regression model. It was observed that gender (OR, 0.001; 95% CI, 0.246-0.716; p=0.42), FEV1(OR, 1.02; 95% CI, 1.00-1.04; p<0.001), P/F (OR, 1.00; 95% CI, 1.00-1.01; p<0.001), and LTOT (OR, 9.83; 95% CI, 3.70-26.14; p<0.001) were independent factors associated with 6MWD<200 m.

Conclusion: The 6-minute walk test is associated with mortality, gender, poor oxygenation, and with the utilization of domiciliary non-invasive mechanical ventilation or long-term oxygen therapy. Furthermore, it is an independent risk factor for mortality in lung transplant candidates and in providing a valuable method for the management of patients.
Distribution of Intestinal Parasites Detected in Ankara Training and Research Hospital between 2017 and 2020
Authors: Kaya Filiz , Kocaağa Mustafa
Published: March 2022

Objective: The aim of this study was to evaluate the current prevalence of intestinal parasites in patients admitted to Ankara Training and Research Hospital during the period of 2017 to 2020.

Materials and Methods: Intestinal parasitic examination results of patients between 2017 and 2020 were evaluated retrospectively. Data on demographic and clinical parameters were obtained from the laboratory information management system.

Results: E. vermicularis eggs were found in 7.2% of 2348 samples examined by cellophane tape method. One or more intestinal parasites were detected in 18.2% of 4211 samples examined stool concentration method. Intestinal parasite positivity was the highest in children aged 6-18 years among age groups. The most frequently detected intestinal parasites were Blastocystis sp., E. vermicularis, Dientamoeba fragilis and Giardia intestinalis.

Conclusion: Although our hospital is in the center of Ankara Training and Research Hospital, it mostly serves patients with low socioeconomic status and immigrant individuals; therefore total intestinal parasite detection rate was found relatively high. Intestinal parasitic infections are still an important public health issue in our country. It is important to determine the prevalence of parasitic infections to develop optimal prevention and treatment strategies.
Comparison of Favipiravir to Hydroxychloroquine Plus Azithromycin in the Treatment of Patients with Non-critical COVID-19: A Single-center, Retrospective, Propensity Score-matched Study
Authors: Uyaroğlu Oğuz Abdullah , Sönmezer Meliha Çağla , Telli Dizman Gülçin , Çalık Başaran Nursel , Karahan Sevilay , Uzun Ömrüm
Published: March 2022

Objectives: In this study, we compared the clinical outcomes and effects of the treatments on laboratory parameters between patients who were treated with favipiravir (FAV) or hydroxychloroquine plus azithromycin (HCQ/AZ) for COVID-19 pneumonia in non-Intensive Care Unit (non-ICU) patients.

Methods: We collected data of 260 moderate or severe COVID-19 patients hospitalized in COVID-19 wards between March 20, 2020, and September 30, 2020 retrospectively. We used propensity score matching to evaluate treatment effect on laboratory parameters of COVID-19 infection.

Results: We compared 42 patients using FAV and 42 HCQ/AZ after propensity score matching. While there were statistical differences between the therapy groups in terms of transfer to ICU and/or exitus before matching (p=0.031), this was not significant after propensity analysis (p=0.250). Patients treated with FAV stayed in the hospital nearly one more day than HCQ/AZ group but the difference was not statistically significant (9.02 days vs 8.14 days, p=0.903). The levels of AST,ALT, and LDH increased at discharge in both groups, especially in the FAV group.

Conclusions: FAV is not superior to HCQ/AZ in the treatment of COVID-19 infection in hospitalized patients with pneumonia.