bluuebunny/crossref_metadata_2025 huggingface dataset:
Pharmacophore-Based Virtual Screening of Novel GSTP1-1 Inhibitors
Authors: BOLELLİ Kayhan , ERTAN-BOLELLİ Tugba
Published: November 2018

Glutathione
transferase enzymes play an important role in metabolism and detoxification of
numerous xenobiotics, electrophilic drugs, environmental carcinogens, and
products of oxidative stress in living organisms.
Human GST P1-1 is the most prevalent
isoform of the mammalian cytosolic GSTs and this enzyme participates in a
particular role in one of the mechanisms of the development of resistance in
cancer cells toward the administration of anticancer agents in chemotherapy.

Herein,
pharmacophore analysis were performed using bioactive conformation of the known
inhibitor of GSTP1-1, ethacrynic acid (pdb ID:2GSS). Phase module of the
Schrödinger suite was used to generate pharmacophore hypothesis. Molecules with
same pharmacophoric features were screened from among the commercially
available compounds in the ZINC database and ligand filtration was also done to
obtain an efficient collection of hit molecules by employing Lipinski “rule of
five” using Qikprop module. As a result, some of the compounds obtained from
this study, could be the promising inhibitors of hGSTP1-1 enzyme.
Türkiye’de Rüzgâr Erozyonu Toprak Duyarlılık Değişkenlerinin Ulusal Ölçekte Belirlenmesi ve Haritalanması
Authors: İNCE Kenan
Published: November 2018

Amaç: Küresel Isınma ve beraberinde gelen iklim değişimine
dair beklentilerin gerçekleşmesi durumunda, Türkiye’de rüzgâr erozyonunun
şiddetini ve etkilediği alan miktarını arttırması beklenilmektedir. Bu yayında
Yenilenmiş Rüzgâr Erozyonu Eşitliğine (Revised Wind Erosion Equation [RWEQ])
ait toprak faktörü verilerinin değerlendirilmesinde kullanılan yaklaşımlara ayrıntılı
olarak yer verilmiştir. Materyal ve Metot: Türkiye
topraklarının rüzgâr erozyonuna duyarlılıklarının belirlenmesinde, koordinatlı
ve noktasal toprak yüzey örneklerine ait 14 801 analiz sonuçlarından
faydalanılmıştır. Bulgular: Yapılan istatiksel analizlere göre sürekli yüzey
haritalarının oluşturulmasında Kriking yönteminin daha uygun sonuçlar verdiği bulunmuştur.
Ayrıca analiz ve haritalandırma sonuçlarına göre ülkemiz
toprakları EF açısından bakıldığında, minimum:0.1132,
maksimum:0.5600, ortalama:0.4173 ve standart sapmasının ise 0.0693 olduğu, SCF
açısından değerlendirildiğinde ise minimum:0.0376, maksimum: 0.7035,
ortalama: 0.1901 ve standart sapmasının ise 0.0878 olduğu bulunmuştur.

Sonuç: Türkiye RWEQ
modeli-tabanlı rüzgâr erozyonu tehlike tahmin teknolojisi uğraşıları, bitki
örtüsü ve arazi pürüzlülüğü parametrelerinin de üretilmesi çalışmaları ile
devam etmektedir. İklim ve toprak parametresine ek olarak, bitki örtüsü ve
arazi pürüzlülüğü parametrelerinin de zamansal ve konumsal ölçeklerde elde
edilmesiyle birlikte, var olan parsel temelli araştırma sonuçları ile
kalibre-edilip doğrulanarak rüzgâr erozyonu haritaları üretilebilecektir. Böylece
kullanılan tahmin sistemi ve ürettiği analitik veri altlıklarının, rüzgâr
erozyonu ile arazi tahribatının görüldüğü bölgelerde, arazi kullanım
planlamalarının hayata geçirilmesinde yaşamsal öneme sahip olması
beklenilmektedir.
18F-FLUOROESTRADIOL PET/CT IN DIFFERENTIAL DIAGNOSIS OF LUNG LESIONS IN BREAST CANCER PATIENTS: CASE REPORTS
Authors: Vikhrova N. В. , Odzharova A. A. , Dolgushin M. В. , Nevzorov D. I.
Published: November 2018

Background. Breast cancer is the second most common cancer worldwide. Despite significant advances in breast cancer treatment, more than 50 % of patients develop recurrence following completion of treatment. If there is a suspicion of disease progression, the differential diagnosis of metastatic tumor and non-metastatic lesion using the standard imaging methods can be difficult. A modern approach to the detection and assessment of the extension of recurrent disease is individual evaluation of the biological characteristics of the tumor, including determination of the status of estrogen receptors with the goal of adequate treatment. PET/CT with 18F-fluoroestradiol in patients with hormone-dependent breast cancer can be used to determine the expression of estrogen receptors (RE) in tumor tissue and assess the presence of receptor-positive metastases throughout the body in a single study.

Case description. We report the cases of 55-year-old and 57-year-old women with hormone-dependent breast cancer after standard treatment (surgery, radiation therapy and hormone therapy). During hormone therapy, lung lesions were detected in both patients. To assess the activity of these lesions, 18F-fluoroestradiol PET/CT was used. In the first case, a low uptake of 18F-FDG was observed. In the other case, no18F-FDG uptake was found. Given that both patients had hormone-dependent breast cancer, it was decided to perform PET/CT with 18F-fluoroestradiol (18F-FES) to evaluate the expression of ER. In the first case, the 18F-FES uptake was detected in all lesions that indicated the evidence of metastases. Histological examination confirmed the evidence of metastatic tumor. In the second case, no uptake of 18FFES was detected in the foci and the patient was followed-up for 6 months. Computed tomography showed decrease in the size of lesions.

Conclusion. The use of 18F-FES PET/CT can be an important diagnostic tool for detection of disease progression in patients with hormone-dependent breast cancer. In case of detection of positive foci on 18F-FES PET/CT scans, hormone therapy for breast cancer can be administered without invasive procedures for verifying the diagnosis.
ARRANGEMENT OF WORK AT PALLIATIVE CARE DEPARTMENT IN ALMETYEVSK BRANCH OF THE REPUBLICAN CLINICAL ONCOLOGICAL DISPENSARY OF THE MINISTRY OF HEALTH OF TATARSTAN REPUBLIC
Authors: Akhmetzyanov F. Sh. , Khayrullin I. I. , Gazizov R. А. , Karamalikov S. A. , Shaimardanov I. V.
Published: November 2018

In the Russian Federation, the incidence of cancer diagnosed at an advanced stage still remains high. A majority of patients (75 %) present with an advanced disease. The goal of palliative care is achievement of the best quality of life and relief of suffering of cancer patients. However, today there is no single model of palliative care.

The aim of the studywas to analyze the activities of the Department of Palliative Care of Almetyevsky Branch of the Republican Clinical Oncology Center of the Republic of Tatarstan.

Material and methods.The Palliative Service of the Republic of Tatarstan is unites several institutions, including the Almetyevsky branch of the Republican Clinical Oncological Dispensary, which was organized in 2015. Based on the population of Almetyevsky region, there are two medical outreach teams.

Results.Between 2016 and 2017, 1 025 patients received palliative care at home, and 6 625 visits were made. Pain syndrome was the most common reason for admission (more than 80 %) followed by depression (more than 80 %), disability disorders (more than 40 %), insomnia (25 %), dyspnea (22 %), and impaired consciousness (5 %). As a result of the creation of this service, a decrease in the number of ambulance visits to patients was recorded: from 92 to 12 % for the reason of severe intolerable pain, from 75 to 6.6 % due to moderate pain and from 6.7 to 0, 3 % due to mild pain. The incidence of unjustified hospital stay decreased by 28 %.

Conclusion.Organization of the team of professionals invoplved in providing high-quality cancer care in Almetyevsk helped to improve the quality of palliative care for incurable cancer patients.
Social and economic drivers of national economic development: the case of OPEC countries
Authors: Saady Mahmood Abaas Mlaabdal , Chygryn Olena , Kubatko Oleksandr , Pimonenko Tetyana
Published: November 2018

This paper examines the economic relationships between oil price volatility and socially-economic development of 14 Organization of the Petroleum Exporting Countries (OPEC) using the annual panel data for the period 1990–2014 obtained from the World Bank (WB) statistical data sets. Hausman specification test has been performed to choose the method of panel data analysis, and the results were in favor of fixed effects estimation. The main findings indicate the direct relationship between economic growth and oil price volatility. The research supports the hypothesis that an increase in crude oil prices is positively related to GDP, and a 10% increase in oil prices correlates with 0.6-4% GDP improvements. Structural changes in employment in favor of service sector are negatively correlated with GDP per capita. Changes in GDP structure in favor of oil rents on 10% lead to the shrinking of GDP on 1%. Life expectancy at birth, as an indirect indicator of health, positively influences the economic growth indicators and an improvement in life expectancy on one percentage leads on average to 1% growth in GDP and 0.5-1.33% growth in GDP per capita. Energy efficiency improvements are positive drivers of GDP values at OPEC, and our findings suggest that a 10% increase at GDP per unit of energy use leads to 3% increase of GDP itself. The study recommends investing in energy efficiency, human capital, and capital formation to guarantee long-run economic development and prosperity of OPEC counties.
Primera época - Año IV, Número 10, enero 2002
Authors: De San Luis Revista de El Colegio
Published: November 2018

Este número corresponde a la primera época de la Revista de El Colegio de San Luis, denominado VETAS.
Primera época - Año IV, Número 12, septiembre-diciembre de 2002
Authors: De San Luis Revista de El Colegio
Published: November 2018

Este número corresponde a la primera época de la Revista de El Colegio de San Luis, denominado VETAS.
In-Vitro Drug Dissolution Studies in Medicinal Compounds
Authors: Bozal-Palabiyik Burcin , Uslu Bengi , Ozkan Yalcin , Ozkan Sibel A.
Published: November 2018

After oral administration, drug absorption from solid dosage forms depends on the
release of the drug active compounds from the dosage form, the dissolution or solubilization
of the drug under physiological conditions, and the permeability across the gastrointestinal
tract. Dissolution testing is an essential part of designing more effective solid dosage forms
in pharmaceutical industry. Moreover, dissolution testing contributes to the selection of appropriate
formulation excipients for improving the dosage form efficiency. This study aims
to analyze in-vitro drug dissolution testing in solid dosage forms since 2010 in order to present
a comprehensive outlook of recent trends. In doing that the previous studies in the literature
are summarized in the form of a table to demonstrate the apparatuses used for dissolution
testing, the media in which the solid dosage form is dissolved, the method preferred for
analysis from dissolution media, the conditions of analyses and the results obtained.
In silico Analysis and Molecular Docking Studies of Novel 4-Amino-3- (Isoquinolin-4-yl)-1H-Pyrazolo[3,4-d]Pyrimidine Derivatives as Dual PI3-K/mTOR Inhibitors
Authors: Panchal Ishan I. , Badeliya Sandip N. , Patel Rakesh , Patel Ashish , Devaligar Animesh
Published: November 2018

Background:

mTORC1/ PI3K control multiple anabolic pathways, including protein
synthesis, ribosome production, lipogenesis, and nucleotide synthesis, are all important for cell and
tissue growth. Sapanisertib and Dactolisib inhibit PI3K/AKT/mTOR pathway, an important signaling
pathway for many cellular functions such as growth control, metabolism and translation initiation.

Methods:

Dactolisib contains quinolin-3-yl-2,3-dihydroimidazo[4,5-c]quinolin scaffold and Sapanisertib
contains benzo[d]oxazol-5-yl-1-ethyl-1H-pyrazolo[3,4-d]pyrimidinnucleous. From the reference
to both of drug novel series of 4-Amino-3-(isoquinolin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin was
developed by molecular docking. In sillico analysis was done with SWISSADME online tools.

Results:

Among all the designed derivatives, compounds 6(-10.6 kcal/mol) , 12( -10.7 kcal/mol),
14( -10.2 kcal/mol), and 16(-10.2 kcal/mol) have a good binding affinity than others. Biological
activity was predicted by Molinspirationonline software tool showing that all compounds are active
on G- protein coupled receptor. In silico toxicity profile of designed compounds was performed
using the SWISSADME program, indicating that all the compounds follow the Lipinski
rule of five and do not penetrate Blood brain barrier.

Conclusion:

Series of pyrazolo[3,4-d]pyrimidin derivatives gives good binding affinity with pan-
PI3-Kinese/Mtor inhibitors. The present study provided a better understanding of the molecular
modeling requisite for maintaining and/or improving PI3K/mTOR inhibitors.
Management of NEC: Surgical Treatment and Role of Traditional X-ray Versus Ultrasound Imaging, Experience of a Single Centre
Authors: De Bernardo Giuseppe , Sordino Desiree , De Chiara Carolina , Riccitelli Marina , Esposito Francesco , Giordano Maurizio , Tramontano Antonino
Published: November 2018

Introduction:

Necrotizing enterocolitis is the most common cause of the postnatal critical
conditions and remains one of the dominant causes of newborns’ death in Neonatal Intensive Care.
The morbidity and mortality associated with necrotizing enterocolitis remains largely unchanged
and the incidence of necrotizing enterocolitis continues to increase. There is no general agreement
regarding the surgical treatment of the necrotizing enterocolitis.

Methods:

In this paper, we want to evaluate the results obtained in our centre from different types of
necrotizing enterocolitis’s surgical treatment and to analyse the role of traditional X-ray versus ultrasound
doppler imaging in the evolutionary phases of necrotizing enterocolitis. The study was
conducted in the Department of Emergency-Urgency NICU, A.O.R.N. Santobono-Pausilipon in
Naples from January 2010 to December 2016. Patients were monitored by hematochemical examinations
and radiological orthostatic exams every 12 hours, so that they had a surgical opportunity
before intestinal perforation occurred. Ultrasonography was performed to monitor preterm infants
who were hospitalized in NICU and that showed NEC symptomatology in phase I Bell staging.

Results:

They were recruited 75 premature infants with NEC symptomatology in phase I-III of Bell
staging, who underwent surgical or medical treatment. In infants with a birth weight >1500 g
(N=30), laparotomy and necrotic bowel resection has generally been our preferred approach. In 46
patients we practiced a primary anastomosis after resection of an isolated necrotic intestinal segment.
In patients with multiple areas of necrosis and dubious intestinal vitality, were performed a
'second-look' scheduled after 24 to 48 hours to re-evaluate the intestine. In the initial phase of necrotizing
enterocolitis, when the radiographic examination shows only a specific dilation of the
loops, ultrasonography shows more and more specific signs, as wall thickening, alteration of parietal
echogenicity, increase in wall perfusion, single or sporadic airborne microbubbles in the thickness
of wall sections.

Conclusion:

Optimal surgical therapy for NEC begins with adequate antibiotic therapy, reintegration
of liquids but above all with timely diagnosis, aimed to discover early prodromic phases of wall
damage by US, a fundamental tool. Abdomen radiography shows specificity frameworks only when
barrier damage is detected while US provides real-time imaging of abdominal structures, highlighting
some elements that are completely excluded by radiograph.
Effect of Chondroitin Sulfate on Blood Serum Cytokine Profile during Carrageenan-induced Edema and Monoiodoacetate-induced Osteoarthritis in Rats
Authors: Korotkyi Oleksandr , Vovk Andrii , Blokhina Oksana , Dvorshchenko Kateryna , Falalyeyeva Tetyana , Abenavoli Ludovico , Ostapchenko Liudmyla
Published: November 2018

Background:

Blood cytokines affect the development of inflammatory processes in both
normal and pathological states. We have studied changes in the concentration of interleukins (ILs) -
1β, IL-4, IL-10, IL-12B p40, transforming growth factor β (TGF β), tumor necrosis factor (TNF-α) in
acute carrageenan-induced inflammation and degenerative-dystrophic changes of knee joint caused
by monoiodoacetate-induced Osteoarthritis (OA) in experimental models on rats. We also investigated
the change in the cytokine profile during prophylactic and therapeutic administration of chondroitin
sulfate to animals under experimental conditions.

Methods: The concentration of the cytokines was measured in blood serum by enzyme-linked immunosorbent
assay.

Results:

The manifestation of articular lesions was characterized by a disturbance in the balance between
proinflammatory (IL-1β, IL-12B p40, TNF-α) and anti-inflammatory (IL-4, IL-10, TGF -β)
cytokines.

Conclusion:

A reduction in the concentration of proinflammatory cytokines in blood serum after
prophylactic and therapeutic administration of chondroitin sulfate to the rat with experimental models
of acute inflammation of the hind limb and degenerative-dystrophic changes in the knee joint
with OA is associated with anti-inflammatory and regenerative properties of the drug.
Review of the Literature Examining the Association of Serum Uric Acid with Osteoporosis and Mechanistic Insights into Its Effect on Bone Metabolism
Authors: Kaushal Neelam , Vohora Divya , Jalali Rajinder K , Jha Sujeet
Published: November 2018

Background And Objective:

Osteoporosis is a common bone disorder that increases susceptibility to fragility bone fractures. The clinical and public health repercussions of osteoporosis are huge due to the morbidity, mortality, and cost of medical care linked with fragility fractures. Clinical assessment of osteoporotic risk factors can help to identify candidates at an early stage that will benefit from medical intervention and potentially lowering the morbidity and mortality seen with fractures and complications. Given this, research is ongoing to evaluate the association of osteoporosis with some novel or less well-studied risk factors/bio-markers such as uric acid (UA).

Discussion:

Uric acid’s antioxidant activity has been proposed to be one of the factors responsible for increasing longevity and lowering rates of age-related cancers during primate evolution, the level of which increased markedly due to loss of uricase enzyme activity (mutational silencing). Accumulated evidence shows that oxidative stress is the fundamental mechanism of age-related bone loss and acts via enhancing osteoclastic activity and increasing bone resorption. Antioxidant substances such as ascorbic acid scavenge free radicals are positively related to bone health. Thus, it is hypothesized that uric acid holds bone-protective potential owing to its potent antioxidative property. Several correlation studies have been conducted globally to investigate the relationship between serum uric acid with bone mineral density and osteoporosis. Few pre-clinical studies have tried to investigate the interaction between uric acid and bone mineral density and reported important role played via Runt-related transcription factor 2 (RUNX2)/core-binding factor subunit alpha-1 (CBF-alpha-1), Wingless-related integration site (Wnt)-3a/β-catenin signaling pathway and 11β Hydroxysteroid Dehydrogenase type 1.

Conclusion:

In this review, the authors provided a comprehensive summary of the literature related to association studies reported in humans as well work done until date to understand the potential cellular and molecular mechanisms that interplay between uric acid and bone metabolism.
Bacterial Meningitis Profile in Newborns: Is the Epidemiology Changing?
Authors: Bennaoui F. , Slitine N. El Idrissi , Cissé S.B. , Soraa N. , Maoulainine F.M.R
Published: November 2018

Objective:

The aim of the study was to determine the epidemiological characteristics of bacterial meningitis observed in neonates.

Materials and Methods:

A retrospective study of all cases of meningitis, hospitalized in the neonatal intensive care unit, Mohamed VI University Hospital, from January 2016 to December 2016.

Results:

Twenty of 794 neonates admitted (2.5%) developed meningitis,with a male predominance (12 boys). The mean age of symptom presentation was 5 days. All patients were symptomatic. The most common clinical features were: fever, respiratory distress and seizure. Microbiological analysis of cerebrospinal fluid was positive in 14 cases and resulted in the isolation of several unusual species such as, Streptococcus pneumoniae (4 cases), Coagulase-negative Staphylococci (3 cases), Enterococci (2 cases), Acinetobacter baumannii (2 cases) and one case each of Escherichia coli , Neisseria meningitidis and Klebsiella pneumonia. Interestingly, the two A. baumannii cases were nosocomially-acquired, while the origins of the other infections were community-acquired. Gram-positive bacteria were more frequently responsible (9/14, 64%). All cases were treated with a combination of third-generation cephalosporins-aminoglycosides, 1 case as treated by by adding ciprofloxacin and 3 cases were treated by adding glycopeptide antibiotics to the clinical therapeutic regimes. We reported 3 cases complicated with hydrocephalus. The mortality rate was 25%.

Conclusion:

Bacterial meningitis is a medical emergency, and immediate diagnostic steps must be taken to establish the specific cause so that appropriate antimicrobial therapy can be initiated. Even with optimal therapy, morbidity and mortality may occur. Neurologic sequelae are common among survivors.
Kelas Cendekia Versi Mobile yang Terintegrasi dengan Sistem Rekomendasi
Authors: Abdurrahmansyah Nur Ridho , Ananta Timur Muhammad Idham
Published: November 2018

Urgency usefulness of online learning system based on social constructivism which is the mobile virtual classroom learning philosophy is of concern, because the system is built on the pattern of reciprocity between users in order to produce the most quality materials see the absence of a system that provides online learning for it. Content of lecture materials that have been divided into certain categories are processed into virtual versions and delivered lightly. The recommendation system is designed to respond users who have rated it by providing good quality course material. Software is created with Unity Engine and incorporated the recommended system protocol with data stored in a scholarly research database. The recommendation system implemented is the items based collaborative filtering with the specification of training data used are 401 rating data, 51 records and 17 users. With sparsity data training amounted to 53.74%, tested the prediction accuracy resulted RMSE 0.91523 and the accuracy of 81.69%. The mobile version of virtual class that has been planted with recommendation system is tried and tested on several brands of android smartphone. Results obtained on the questionnaire resulted in a rating of 4,762 on performance and 4,572 against the intellectual class software interface. Whereas the level of user enthusiasm for the virtual class reaches 4,0588 on a scale of 1 to 5.
Low Cost Sensor Node Device for Monitoring Landslides
Authors: Awaludin Lukman , Dhewa Oktaf Agni
Published: November 2018

Landslides are one of the natural disasters that often occur in Indonesia. Therefore, this disaster cannot be eliminated, but it can minimize the disadvantage caused by an early warning mechanism. Early warning systems rely on a sensor node used to read soil conditions with specific parameters. Those parameters that are read lead to the detection of mass movements. With the tightness of the monitoring process, of course, a reliable sensor node is needed. However, there are challenges in how to minimize losses that occur due to damage to sensor nodes when landslides occur. Sensor nodes are made using IMU sensors to monitor mass movements and its use two processors, namely microcontroller and mini SBC, which are inexpensive to manufacture and do not require large space in the installation.
Potensi Simpanan Karbon pada Beberapa Tipologi Hutan Rawa Gambut di Kalimantan Tengah
Authors: Qirom Muhammad Abdul , Yuwati Tri Wira , Santosa Purwanto Budi , Halwany Wawan , Rachmanadi Dony
Published: November 2018

Akurasi pendugaan simpanan karbon hutan rawa gambut dapat ditingkatkan melalui pengukuran masing-masing gudang/sumber karbon dan berbagai macam tipologi hutannya. Pengukuran tersebut berkaitan dengan besarnya kandungan dan fraksi simpanan karbon pada masing-masing gudang karbon. Penelitian ini bertujuan untuk mendapatkan kandungan dan potensi simpanan karbon pada masing-masing gudang karbon di tipologi gambut. Pengukuran simpanan karbon dilakukan pada lima gudang karbon yakni vegetasi (tingkat permudaan pohon), serasah, tumbuhan bawah, nekromasa dan tanah. Hasil penelitian menunjukkan kandungan karbon adalah 50% dari berat kering biomassa. Kandungan karbon tidak dipengaruhi oleh gudang karbon dan tipologi gambut. Pada tanah gambut, kedalaman gambut mempengaruhi besarnya kandungan karbon sehingga besarnya faktor konversi harus memperhatikan kedalaman masing-masing tipologi gambut. Potensi simpanan karbon terbesar pada tipologi hutan sekunder dengan kedalaman gambut antara 3-3,5 m sebesar 3.722,08 Mg/ha sedangkan potensi simpanan karbon terendah pada tipologi semak belukar dengan kedalaman gambut 3-3,5 m sebesar 2243,49 Mg/ha. Pada hutan gambut, gudang karbon tanah menyumbang >95% dari simpanan karbon total. Gudang karbon nekromasa memberikan sumbangan simpanan karbon terkecil. Fraksi simpanan karbon pada masing-masing gudang karbon berturut-turut adalah tanah> vegetasi> serasah> tumbuhan bawah> nekromasa.Carbon Stocks Potential of Peatland Forests Typologies in Central KalimantanAbstractAccuracy of carbon stocks estimation can be enhanced by measuring each carbon pools in various forest peatland typologies. The carbon stocks measurement is associated with the amount of contents and fractions of carbon stocks. The research objectives were to obtain the information of carbon contents and carbon stocks potentials in each carbon pool in the peat typologies. Carbon stocks measurement was conducted in five carbon pools which were: vegetation (tree stages), litter, understory, necromass, and soil. The results showed that the carbon contents reached more than 50% of its dry weight. The carbon contents were not affected by the carbon pools and peat typologies. In the soil carbon pools, peat depth affected the amount of carbon content so that the magnitude of the conversion factor should concentrate to the depth of each peat typology. The greatest potential of carbon stocks was found in the secondary forest (3,733.08 Mg/ha) with the peat depths between 3-3.5 m, while the lowest potential of carbon stocks found in the bush typology (2243.49 Mg/ha) with the peat depths between 3-3.5 m. In the peat typology, soil carbon stocks contributed more than 95% of total carbon stocks whereas necromass carbon stocks contributed the smallest amount of carbon. The fractions of carbon stocks in each carbon pools were soil> vegetation> litter> understorey> necromass, respectively.
Uji Fitokimia dan Aktivitas Antibakteri Tumbuhan Pranajiwa (Euchresta horsfieldii (Lesch.) Benn.)
Authors: Prihantini Amalia Indah , Krisnawati Krisnawati , Rahayu Anita Apriliani Dwi , Nugraheni Yosephin Martha Maria Anita , Samawandana Gipi
Published: November 2018

Euchresta horsfieldii merupakan tanaman obat yang dikenal di Nusa Tenggara Barat dan Bali sebagai pranajiwa. Pada penelitian ini telah dilakukan analisis fitokimia dan aktivitas antibakteri dari akar, batang, daun, dan biji pranajiwa. Pengujian aktivitas antibakteri dilakukan terhadap bakteri Bacilus subtilis Inacc-B334, Staphylococccus aureus Inacc-B4, dan Escherchia coli Inacc-B5. Hasil analisis fitokimia menunjukkan bahwa alkaloid sebagai komponen senyawa yang paling dominan pada pranajiwa dan terdeteksi di setiap bagian tanaman. Bagian akar pranajiwa terdeteksi memiliki komponen senyawa yang paling bervariasi seperti alkaloid, tanin, flavonoid, saponin, dan terpenoid. Analisis GC-MS dari batang, akar, dan biji pranajiwa menunjukkan mome inositol, sophoridane, dan asam lemak seperti asam palmitat dan asam stearat sebagai komponen utamanya. Adapun uji aktivitas antibakteri pranajiwa menunjukkan bagian batang dan akar memiliki aktivitas antibakteri terhadap S. aureus Inacc-B4 dan E. coli Inacc B-5, sedangkan bagian biji memiliki aktivitas antibakteri terhadap B. subtilis Inacc-B-334 dan S. aureus Inacc-B4. Hasil-hasil penelitian tersebut dapat mendukung penelitian terkait potensi E. horsfieldii sebagai sumber alternatif obat antibakteri. Phytochemical Test and Antibacterial Activity of Pranawija (Euchresta horsfieldii (Lesch.) Benn.)AbstractEuchresta horsfieldii is a medicinal plant known in West Nusa Tenggara and Bali as pranajiwa. This study investigated phytochemical analysis and antibacterial activity of roots, stems, leaves, and seeds of E. horsfieldii. The samples were analyzed for their antibacterial activity against Bacilus subtilis Inacc-B334, Staphylococccus aureus Inacc-B4, and Escherchia coli Inacc-B5. The phytochemistry result indicated that alkaloids was the most dominant constituent of E. horsfieldii as it was detected in all parts of the plant. GC-MS analysis of the stems, roots, and seeds showed mome inositol, sophoridane, and fatty acids such as palmitic acid and strearic acid as the main components. The roots had the most varied constituents with detection of alkaloids, tannins, flavonoids, saponins, and terpenoids. Further, antibacterial activity assay showed that the stems and roots had antibacterial activity against S. aureus Inacc-B4 and E. coli Inacc B-5, whereas the seeds had antibacterial activity against B. subtilis Inacc-B-334 and S. aureus InaccB4. The result of the present study supports the investigation on potentiality of E. horsfieldii as alternative source for antibacterial agents.
The New Turkish Presidential System
Authors: Altinors Mehmet Nur
Published: November 2018

The New Turkish Presidential System
Real-world US healthcare costs of psoriasis for biologic-naive patients initiating apremilast or biologics
Authors: Feldman Steven R , Pelletier Corey L , Wilson Kathleen L , Mehta Rina K , Brouillette Matthew A , Smith David , Bonafede Machaon M
Published: November 2018

Aim:
Biologics and apremilast have advanced psoriasis management by adding treatment options. This study evaluated persistence, adherence and healthcare costs among biologic-naive patients receiving apremilast or biologics.
Methods:
Administrative claims data for adults starting apremilast or biologics from 1 January 2013 to 30 June 2016 were matched based on demographics.
Results:
Apremilast (n = 703) and biologics (n = 1378) had similar baseline characteristics. 12-month persistence and adherence rates were similar. Adjusted total healthcare costs were lower with apremilast versus biologics (p < 0.001) due to lower total outpatient pharmacy costs (p < 0.001).
Conclusion:
Real-world apremilast users had similar adherence and lower total healthcare costs versus biologic users. Apremilast's cost advantage was evident regardless of whether the patients were persistent or nonpersistent, or switched or did not switch treatments.
Ovarian activity regulation by anti-Müllerian hormone in early stages of human female life, an overview
Authors: Jusiakowska-Piputa Małgorzata , Kaczmarek Maria
Published: November 2018

The present study aimed at describing the anti-Müllerian hormone (AMH), with special focus on molecular background for ovarian activity, in particular the role AMH plays in sex determination and gonadogenesis process in early stages of prenatal life and folliculogenesis in postnatal life. It is a review of the literature currently indexed and abstracted in MEDLINE, SCOPUS and Google Scholars. The process of sex determination and gonad differentiation occurring during embryogenesis was discussed along with underlying molecular mechanisms. In the postnatal life the impact of AMH on the process of folliculogenesis was described. Clinical use of recent findings was shown as well. Genetic studies and molecular analyses have demonstrated that AMH is highly conservative, indicating its significance in reproductive process on the background of evolutionary processes.
La influencia de la iniciativa URBANA 2007-2013 en el desarrollo de la capacidad institucional de la administración municipal
Authors: Casado Maestre Valle , Huete García María Ángeles , Merinero Rodríguez Rafael , González Medina Moneyba
Published: November 2018

Desde hace años, la Unión Europea viene haciendo especial énfasis en la promoción de la capacidad institucional de las administraciones en el marco de los programas de desarrollo local y urbano. Sin embargo, hasta el momento son pocos los trabajos destinados al análisis de la capacidad institucional entre las administraciones locales españolas como producto de estas iniciativas. Este trabajo se destina al estudio de la promoción de dicha capacidad en las ciudades españolas que han implementado programas de desarrollo, en concreto, la iniciativa URBANA 2007-2013.A través de la administración de un cuestionario entre los ayuntamientos españoles y entrevistas en profundidad con actores clave en el diseño e implementación del programa, se trata de analizar la medida en que dicha capacidad se ha desarrollado, así como la relación entre su nivel de desarrollo y otros elementos del contexto local o institucional, como son la experiencia previa acumulada en programas similares y el modelo de gestión en el marco del cual se implementa el programa. Estos elementos se mostrarán como factores clave en el desarrollo de la capacidad institucional.
Jaime FERRI DURÁ y Manuel BARROSO SEVILLANO (coords.). Ciudadanía y servicios públicos locales: Un estudio en las comunidades autónomas de Madrid y Castilla y León
Authors: Keidel Fernández Mirian
Published: November 2018

El presente monográfico es el resultado de la coordinación por parte de Jaime Ferri Durá y Manuel Barroso de una investigación sobre la prestación de servicios públicos locales, en la que participan Juan C. Cuevas Lanchares, Eduardo Gutiérrez Díaz, Eliseo López Sánchez, Francisco J. Loscos, Luis Pérez Rodríguez y en la que también colaboran  Tomás Villasante, Manuel Tamayo y Ernesto Carrillo tras haber colaborado  en un Curso de verano de la UCM impartido en San Lorenzo de El Escorial en julio de 2016.
Rancang Bangun Aplikasi Jelajah Virtual Panorama Berbasis Web Pada Universitas PGRI Madiun
Authors: Anwar Muhammad Syaiful
Published: November 2018

Universitas PGRI Madiun merupakan salah satu perguruan tinggi unggulan di Jawa Timur. Untuk memudahkan masyarakat terutama calon mahasiswa baru, diperlukan sebuah aplikasi yang dapat menyajikan informasi mengenai lokasi dan fasilitas yang ada. Aplikasi jelajah virtual ini dirancang untuk mengatasi permasalahan tersebut. Dengan memanfaatkan gambar panorama yang telah disesuaikan, sehingga pengguna aplikasi dapat merasakan pengalaman berkunjung ke Universitas PGRI Madiun secara online terasa realistis. Metode perancangan yang digunakan dalam penelitian ini adalah metode Waterfall. Hasil dari penelitian ini berupa sebuah aplikasi jelajah virtual berupa halaman web yang dapat diakses dari manapun selama ada koneksi internet. Dengan adanya aplikasi ini diharapkan minat calon mahasiswa baru Universitas PGRI Madiun dari luar daerah Madiun makin meningkat.
INTEGRASI PENDIDIKAN KARAKTER TANGGUNG JAWAB PADA PEMBELAJARAN BIOLOGI MATERI METODE ILMIAH MELALUI PEMBELAJARAN BERBASIS PROYEK BERBANTUAN FORMO
Authors: Atmawati Trisni
Published: November 2018

The research problem is how to integrate the character of responsibility in formo-based project-based learning and how to improve the character of student responsibilities after formo-based project-based learning. This research is a research and development research, with a sample of students of class X SMAN 1 Purworejo Lesson year 2017/2018. The results of this study are formo-assisted project-based learning that can integrate the character of responsibility through the use of formo planning at the end of the project preparation phase, the implementation formo at the project implementation stage and final form in the test result stage; 2) there is an increase of student responsibility from the beginning of preparation project up to the finished project ie from 80% to 100%.
Penggunaan Metode Take and Give untuk Meningkatkan Motivasi dan Prestasi Belajar Siswa pada Materi “Otonomi Daerah” SMP Negeri 3 Maospati Magetan
Authors: Suhadi Suhadi
Published: November 2018

Penelitian ini dilatarbelakangi oleh rendahnya prosentase ketercapaian atas Kriteria Ketuntasan Minimal (KKM) yang diperoleh siswa kelas IX H SMP Negeri 3 Maospati. Dari jumlah siswa 22 orang yang mengikuti post tes pada bahan ajar Otonomi Daerah dengan pembelajaran model Take and Give, hanya 3 orang yang dapat dinyatakan lulus (14%) dan sisanya  19 orang dinyatakan belum lulus (86%). Oleh karena itu, untuk kasus tersebut perlu diadakan remedial klasikal. Proses remedial klasikal dalam kasus ini penulis lakukan melalui kegiatan penelitian tindakan kelas.Penerapan metode  take and give dapat meningkatkan motivasi dan prestasi belajar bidang studi PKn pada siswa kelas IX H  SMP Negeri 3 Maospati. Dari aspek motivasi belajar siswa terjadi kenaikan dari siklus 1 ke siklus 2. Pada siklus 1 rata-rata skor motivasi belajar siswa mencapai 57,4, sedangkan pada siklus 2 rata-rata skor motivasi belajar siswa mencapai 77. Nilai prestasi belajar siswa bisa dilihat dari hasil test yang dilakukan guru setelah selesai melaksanakan kegiatan belajar mengajar. Sebagai data awal atau prasiklus nilai rata-rata mencapai 57, kemudian siklus 1 mandapatkan nilai rata-rata 64. Pada siklus 2 nilai rata2 menacapai 78. Sedangkan data aktivitas guru menunjukkan ada kenaikan antara siklus 1 bila dibandingkan dengan siklus 2. Siklus 1 mendapat rata-rata skor 65 dan siklus 2 mendapat rata-rata skor 90.
Penerapan Metode Investigasi Kelompok Untuk Meningkatkan Sikap Solidaritas Sosial Dan Keterampilan Komunikasi Siswa Kelas V SDN Selosari 2 Magetan Semester Gasal Tahun Pelajaran 2017/2018
Authors: Setyowati Mamik
Published: November 2018

Penelitian ini bertujuan untuk meningkatkan sikap solidaritas sosial dan keterampilan komunikasi siswa kelas V SDN Selosari 2 Magetan Semester Gasal Tahun Pelajaran 2017/2018 dengan menerapkan investigasi kelompok. Ada beberapa penyebab rendahnya sikap solidaritas sosial dan keterampilan komunikasi IPS, diantaranya karena penggunaan mengajar selama ini masih sangat monoton yang didominasi ceramah sehingga aktivitas anak kurang nampak. Maka menjadi suatu tantangan bagi seorang guru untuk senantiasa melakukan inovasi dalam menggunakan mengajar. Subyek penelitian yang digunakan oleh peneliti adalah kelas V SDN Selosari 2 sebanyak 25 anak. Pengumpulan data dalam penelitian ini menggunakan wawancara dan observasi. Dalam Penelitian Tindakan Kelas ini peneliti bekerja sama dengan salah seorang guru sebagai kolaborator sekaligus observer dalam mengamati aktivitas belajar siswa. Penerapan investasi kelompok dapat meningkatkan keterampilan komunikasi dan sikap solidaritas siswa kelas V SDN Selosari 2. Aspek keterampilan komunikasi terjadi kenaikan pada siklus 2 daripada siklus 1. Nilai rata-rata pada siklus 1 mencapai 74,5, sedangkan pada siklus 2 naik menjadi 93. Sedangkan aspek sikap solidaritas sosial siswa selama kegiatan belajar mengajar juga mengalami kenaikan. Siklus 1 mendapatkan rata-rata 75,5, sedangkan pada siklus 2 mencapai 90,5. 
Implementasi Graphical User Interface (GUI) MATLAB untuk analisis spektrum biosensor berbasis Surface Plasmon Resonance (SPR)
Authors: Nurrohman Devi Taufiq , Purwanto Riyadi
Published: November 2018

Penelitian ini bertujuan untuk membuat aplikasi sederhana menggunakan GUI MATLAB untuk menganalisis spektrum biosensor berbasis Surface Plasmon Resonance (SPR). Metode yang dilakukan dalam pembuatan aplikasi dimulai dari tahap analisis, tahap desain interface, tahap coding dan tahap pengujian. Tombol Kurva simulasi pada menu editor berisi perintah untuk menampilkan spektrum SPR simulasi berdasarkan data indeks bias dan ketebalan yang dimasukkan dalam data input. Sedangkan Kurva Eksperimen berisi perintah untuk menampilkan titik – titik hasil eksperimen. Akhirnya sensitifitas dari biosensor berbasis SPR dapat ditentukan nilainya dengan mengganti nilai – nilai pada penel input data. Selain itu sistem SPR yang tidak diketahui nilai indeks bias dan ketebalannya dapat diprediksi nilainya dengan membandingkan kurva simulasi dan kurva eksperimen.
Karakteristik Gain kaca TZB yang didadah Ion Er3+ untuk penguat pada sistem komunikasi Optik
Authors: Susanto Rudi , Hasanah Herliyani
Published: November 2018

Paper ini menyajikan karakteristik gain pada kaca tellurite dengan komposisi 55TeO2-2Bi2O3-(43-x)ZnO-xEr2O3 dimana (x=0,5; 1,0; 1,5; 2,0; 2,5; 3,0). Serapan optik kaca diukur mengunakan Ultra Violet-Visible Spectroscopy (UV-Vis) lambda 25. Pengukuran dilakukan pada panjang gelombang 400 nm sampai dengan 1100 nm dengan range 0,1 nm.  Pola cross section emisi serta absorbsi kaca didapat dengan menggunakan persamaan McCumber kemudian digunakan untuk menentukan gain cross section.  Hasil penelitian menunjukkan bahwa penguatan muncul saat rasio inversi mencapai 0,4 atau lebih karena emisi lebih dominan dan dapat mengimbangi absorbsi. Berdasarkan hasil penelitian urutan tinggi intensitas puncak gain cross section pada berbagai rasio inversi dari tinggi ke rendah adalah x=3.0> x=1.0> x=2.5> x=1.5> x=0.5> x=2.0.
Pengembangan modul fisika berbasis Scientific Approach untuk meningkatkan Keterampilan Proses Sains siswa
Authors: Sumiati Eli , Septian Damar , Faizah Faizah
Published: November 2018

Modul fisika berbasis scientific approach dikembangkan untuk meningkatkan keterampilan proses sains siswa yang disesuaikan dengan hakikat sains sebagai proses, karakteristik materi fluida statis, dan penggunaan kurikulum 2013 yang identik dengan scientific approach. Penggunaan modul ini bertujuan untuk mengetahui: (1) karakteristik hasil pengembangan modul fisika berbasis scientific approach, (2) keefektifan penggunaan modul fisika berbasis scientific approach dalam meningkatkan keterampilan proses sains siswa. Penelitian ini merupakan penelitian Research and Development (R&D) yang mengacu pada model Four-D (4D). Data dari angket dianalisis secara deskriptif dengan persentase sedangkan data hasil keterampilan proses sains siswa dianalisis dengan uji t dua sampel berpasangan menggunakan software IBM SPSS Statistics 19, uji n gain score, dan uji effect size dari Cohen. Berdasarkan hasil analisis data disimpulkan: (1) karakteristik modul menyajikan materi yang meninjau aspek keterampilan proses sains (menginterpretasi, memprediksi, mengaplikasikan konsep, merancang percobaan, dan mengkomunikasikan); (2) modul memiliki nilai keefektifan sebesar 64% dalam kategori “efektif”dengan nilai effect size sebesar 1,32 dalam kategori “Besar”.
Pengembangan model pembelajaran sains kontekstual untuk peserta didik difabel netra
Authors: Winarti W
Published: November 2018

Penelitian ini bertujuan untuk mengembangkan sebuah model pembelajaran sains berbasis kontekstual untuk peserta didik difabel netra dalam setting sekolah inklusi. Model yang dikembangkan ini menjadi sangat penting untuk memfasilitasi kelamahan pembelajaran fisika selama ini untuk peserta didik difabel netra. Penelitian ini merupakan penelitian pengembangan (Research and Development) yang mengacu pada langkah pengembangan dari Borg & Gall. Dari sepuluh langkah penelitian pengembangan Borg & Gall, pada penelitian ini dibatasi pada tahap validasi. Hasil penelitian ini menunjukkan bahwa telah berhasil dikembangkan model pembelajaran sains kontekstual untuk peserta didik difabel netra dengan nama Model pembelajaran Art of Contextual Learning for Disability (A-CLeD).  Model A-CLeD ini memiliki sintak yaitu; (1) Orientasi, (2) Korelasi, (3) Transformasi, (4) Mediasi dan (5) Refleksi.  Hasil validasi isi (content validity) terhadap model ini menunjukkan kesimpulan bahwa model ini berkategori baik dan dapat digunakan dalam pembelajaran fisika untuk peserta didik difabel netra.
Karakteristik keterampilan berpikir kreatif dalam pemecahan masalah fisika berdasarkan gender
Authors: Trianggono Muhammad Maulana , Yuanita Setyaningsih
Published: November 2018

Setiap orang memiliki potensi kreatif yang berbeda-beda. Perbedaan tersebut dapat dipengaruhi oleh pengalaman, pola berpikir, cara menentukan sudut pandang, dan faktor-faktor lainnya. Penelitian ini bertujuan untuk mendeskripsikan perbedaan karakteristik keterampilan berpikir kreatif antara laki-laki dan perempuan dalam konteks pemecahan masalah fisika. Subjek yang diteliti adalah mahasiswa berusia antara 18-20 Tahun yang terdiri dari 5 laki-laki dan 5 perempuan. Perbedaan karakteristik keterampilan berpikir kreatif tersebut dianalisis secara kuantitatif menggunakan uji-t dan secara deskriptif berdasarkan hasil observasi pada pola jawaban dalam tes uraian. Berdasarkan hasil analisis uji-t antara keterampilan berpikir kreatif laki-laki dan perempuan, secara umum tidak terdapat perbedaan yang signifikan antara keduanya dengan t hitung (0,75) < t tabel (1,86). Perbedaan karakteristik keterampilan berpikir kreatif baru terlihat pada indikator keterampilan berpikir kreatif, yakni pada indikator fluency, flexibility, dan elaboration, sedangkan pada indikator originality tidak terdapat perbedaan yang signifikan. Perbedaan karakteristik yang terjadi dalam penelitian ini disebabkan oleh perbedaan pola penalaran antara subjek laki-laki dan perempuan dalam memecahkan masalah fisika yang diberikan. Subjek laki-laki cenderung menuangkan banyak ide dan penalaran jawaban yang bervariasi, sedangkan subjek perempuan memiliki kecenderungan untuk merinci secara detail jawaban yang dikemukakannya
PELATIHAN PEMBUATAN BAHAN AJAR BERBASIS TEKNOLOGI INFORMASI DENGAN CAMTASIA STUDIO BAGI GURU DI SMK MUHAMMADIYAH 2 MUNTILAN - MAGELANG
Authors: Sholeh Muhammad , Suraya Suraya , Suraya Ign.
Published: November 2018

Abstract. Teaching materials as one of the media that teachers can use to explain the material to the students. In the era of the development of information technology today, teachers must develop teaching materials that utilize information technology. With the support of information technology, materials or teaching materials that are packaged can be displayed more interesting and interactive. Many applications that teachers can use in creating teaching materials. One of them is Camtasia Studies. With this application, teachers do not need a programming understanding in the development of teaching materials. This application developed video-based and can be equipped with more attractive appearance. As an effort to improve the role of teachers in developing teaching materials, in SMK Muhammadiyah 2 Muntilan has been held training to create teaching materials with Camtasia Studio application. The
results of training to produce teaching materials and ready to be given to students either through flash disk or uploaded in elearning school.

Abstrak. Bahan ajar sebagai salah satu media yang dapat digunakan guru untuk menjelaskan materi kepada para siswa. Di era perkembangan teknologi informasi saat ini, guru harus mengembangkan bahan ajar yang memanfaatkan teknologi informasi. Dengan dukungan teknologi informasi, materi atau bahan
ajar yang dikemas dapat ditampilkan lebih menarik dan interaktif. Banyak aplikasi yang dapat digunakan guru dalam membuat bahan ajar. Salah satu nya adalah Camtasia Studi. Dengan aplikasi ini, guru tidak memerlukan pemahaman pemrograman dalam pengembangan kan bahan ajar. Aplikasi ini dikembangkan
berbasis video dan dapat dilengkapi dengan tampilan-tampilan yang lebih menarik. Sebagai upaya meningkatkan peran guru dalam mengembangkan bahan ajar, di SMK Muhammadiyah 2 Muntilan telah diselenggarakan pelatihan membuat bahan ajar dengan aplikasi Camtasia Studio. Hasil pelatihan  menghasilkan bahan ajar dan siap untuk diberikan ke siswa baik melalui flash disk maupun di unggah di elearning sekolah.