bluuebunny/crossref_metadata_2025 huggingface dataset:
Use of Novel m6A Regulator-mediated Methylation Modification Patterns in Distinct Tumor Microenvironment Profiles to Identify and Predict Glioma Prognosis and Progression, T-cell Dysfunction, and Clinical Response to ICI Immunotherapy
Authors: Zhang Wenxiong , Zhao Binghao , Xiang Zhongtian , Wu Bo , Zhang Xiang , Feng Nan , Wei Yiping
Published: December 2022

Background:

The specific functions of RNA N6-methyladenosine (m6A) modifications in the glioma
tumor microenvironment (TME) and glioma patient prognosis and treatment have not been determined to
date.

Objective:

The objective of the study was to determine the role of m6A modifications in glioma TME.

Methods:

Nonnegative matrix factorization (NMF) methods were used to determine m6A clusters and m6A
gene signatures based on 21 genes relating to m6A modifications. TME characteristics for each m6A cluster
and m6A gene signature were quantified by established m6A score. The utility of m6A score was validated in
immunotherapy and other antiangiogenic treatment cohorts.

Results:

Three m6A clusters were identified among 3,395 glioma samples, and they were linked to different biological
activities and clinical outcomes. The m6A clusters were highly consistent with immune profiles known
as immune-inflamed, immune-excluded, and immune-desert phenotypes. Clusters within individual tumors
could predict glioma inflammation, molecular subtypes, TME stromal activity, genetic variation, alternative
splicing, and prognosis. As for the m6A score and m6A gene signature, patients with low m6A scores exhibited
an increased tumor mutation burden, immune activity, neoantigen load, and prolonged survival. A low m6A
score indicated the potential for a low level of T-cell dysfunction, a considerably better treatment response, and
durable clinical benefits from immunotherapy, bevacizumab and regorafenib.

Conclusion:

Glioma m6A clusters and gene signatures have distinctive TME features. The m6A gene signature
may guide prognostic assessments and promote the use of effective strategies.
High-Intense Interval Training Prevents Cognitive Impairment and
Increases the Expression of Muscle Genes FNDC5 and PPARGC1A in a
Rat Model of Alzheimer's Disease
Authors: Nogueira Godinho Welton Daniel , Vasconcelos Filho Francisco Sérgio Lopes , Pinto Daniel Vieira , Alves Juliana Osório , de Souza Nascimento Tyciane , de Aguiar Isabele Dutra , Silva Almeida Guilherme Nizan , Ceccatto Vânia Marilande , Soares Paula Matias
Published: December 2022

Background:

Alzheimer's disease is the most common neurodegenerative disease in the world, characterized by the progressive loss of neuronal structure and function, whose main histopathological landmark is the accumulation of β-amyloid in the brain.

Objective:

It is well known that exercise is a neuroprotective factor and that muscles produce and release myokines that exert endocrine effects in inflammation and metabolic dysfunction. Thus, this work intends to establish the relationship between the benefits of exercise through the chronic training of HIIT on cognitive damage induced by the Alzheimer's model by the injection of β amyloid 1-42.

Methods:

For this purpose, forty-eight male Wistar rats were divided into four groups: Sedentary Sham (SS), Trained Sham (ST), Sedentary Alzheimer’s (AS), and Trained Alzheimer’s (AT). Animals were submitted to stereotactic surgery and received a hippocampal injection of Aβ1-42 or a saline solution. Seven days after surgery, twelve days of treadmill adaptation followed by five maximal running tests (MRT) and fifty-five days of HIIT, rats underwent the Morris water maze test. The animals were then euthanized, and their gastrocnemius muscle tissue was extracted to analyze the Fibronectin type III domain containing 5 (FNDC5), PPARG Coactivator 1 Alpha (PPARGC1A), and Integrin subunit beta 5 (ITGB5-R) expression by qRT-PCR in addition to cross-sectional areas.

Results:

The HIIT prevents the cognitive deficit induced by the infusion of amyloid β 1-42 (p<0.0001), causes adaptation of muscle fibers (p<0.0001), modulates the gene expression of FNDC5 (p<0.01), ITGB5 (p<0.01) and PPARGC1A (p<0.01), and induces an increase in peripheral protein expression of FNDC5 (p<0.005).

Conclusion:

Thus, we conclude that HIIT can prevent cognitive damage induced by the infusion of Aβ1-42, constituting a non-pharmacological tool that modulates important genetic and protein pathways.
Identification of Potential Inhibitors of PDE5 based on Structure-based
Virtual Screening Approaches
Authors: Xu Lei , Sun Lilei , Su Peng , Ma Teng , Yu Yingcong , Liu Haibin , Huang Xianfeng
Published: December 2022

Background:

Phosphodiesterase type 5 (PDE5), exclusively specific for cyclic guanidine
monophosphate (cGMP), a potential target for the therapy of various diseases, and PDE5 inhibitors
could be used as a treatment for erectile dysfunction (ED) or chronic pulmonary hypertension.

Objective:

In the present study, we carried out an integrated computer-aided virtual screening
technique against the natural products in the ZINC database to discover potential inhibitors of
PDE5.

Methods:

Pharmacophore, molecular docking and ADMET (Absorption, distribution, metabolism,
excretion and toxicity) properties filtration were used to select the PDE5 inhibitors with the best
binding affinities and drug-like properties. The binding modes of PDE5 inhibitors were investigated,
and these complexes' stabilities were explored by molecular dynamic simulations and
MM/GBSA free energy calculations.

Results:

Two natural compounds (Z171 and Z283) were identified and may be used as a critical
starting point for the development of novel PDE5 inhibitors. The MM/GBSA free energy decomposition
analysis quantitatively analyzed the importance of hydrophobic interaction in PDE5-
ligands binding.

Conclusion:

In this study, we identified two novel natural compounds from the ZINC database to
effectively inhibit PDE5 through virtual screening. The novel scaffolds of these compounds can be
used as the starting templates in the drug design of PDE5 inhibitors with good pharmacokinetic
profiles. These results may promote the de novo design of new compounds against PDE5.
An Overview of Radiolabeled RGD Peptides for Theranostic Applications
Authors: Badipa Fateme , Alirezapour Behrouz , Yousefnia Hassan
Published: December 2022

Angiogenesis phenomenon, as a highly affecting factor on the growth and spread of
cancer cells, depends on specific molecular interactions between components of the extracellular
matrix and vascular cells. αv integrin acts as a cell adhesive molecule involved in tumor invasion
and angiogenesis. Among the various combinations of integrin subunits expressed on the surface
of cells, αvβ3 integrin has a particularly interesting expression pattern during angiogenesis. The
αvβ3 integrin is a vital receptor affecting tumor growth, tumor invasiveness, metastasis, and angiogenesis
overexpressed on various human tumors, leading to the development of different
theranostics probes and radiopharmaceuticals. The αvβ3 integrin can recognize several extracellular
matrix molecules in the base of the RGD adhesive sequence. This review provides an overview
of the status, trends and future of the most studied αvβ3 integrin-binding ligand, RGD tripeptides,
labeled with various radioisotopes. An overview of the pre-clinical models for radiolabeled RGD
peptides and clinical aspects of the RGD- based radiopharmaceuticals is provided with some new
considerations and ways forward.
Emergence of BA.4/BA.5 Omicron Sub-lineages and Increased SARSCoV-
2 Incidence in Senegal
Authors: Diagne Moussa Moise , Diallo Amadou , Sankhe Safietou , Top Ndeye Marieme , Kane Mouhamed , Mbanne Maimouna , Faye Martin , Barry Mamadou Aliou , Dia Ndongo , Sall Amadou Alpha , Loucoubar Cheikh , Faye Ousmane
Published: December 2022

Background:

The Omicron variant B.1.1.529 has led to a new dynamic in the COVID-19 pandemic, with an increase in cases worldwide. Its rapid propagation favors the emergence of novel sub-lineages, including BA.4 and BA.5. The latter has shown increased transmissibility compared to other Omicron sub-lineages. In Senegal, the emergence of the Omicron variant in December 2021 characterized the triggering of a short and dense epidemiological wave that peaked at the end of February. This wave was followed by a period with a significant drop in the number of COVID-19 cases, but an upsurge in SARS-CoV-2 infection has been noted since mid-June.

Objective:

The purpose of this brief report is to give an update regarding the genomic situation of SARS-CoV-2 in Dakar during this phase of recrudescence of cases.

Methods:

We performed amplicon-based SARS-CoV-2 sequencing on nasopharyngeal swab samples from declared COVID-19 patients and outbound travelers that tested positive.

Results:

Ongoing genomic surveillance activities showed that more than half of recent COVID-19 cases were due to the BA.4 and BA.5 sub-lineages that share two critical mutations associated with increased transmissibility and immune response escape. The circulation of recombinants between Omicron sub-lineages was also noted.

Conclusion:

Despite the lack of proven severity of BA.4 and BA.5 sub-lineages, their increased transmissibility causes a rapid spread of the virus, hence a surge in the number of cases. This rapid spread constitutes a greater risk of exposure for vulnerable patients. To tackle this issue, any increase in the number of cases must be monitored to support public health stakeholders. Therefore, genomic surveillance is an ever-essential element in managing this pandemic.
Airway Management in Pregnancy
Authors: Martinez Hurtado Eugenio D. , Agudo Laura Reviriego , Charco Mora Pedro , Fernández Vaquero Miguel Ángel , Gómez Rojo María
Published: December 2022

Airway management in the obstetric patient is a challenge for
anaesthesiologists, not only because of the anatomical and physiological changes
during pregnancy, but also because of the surgery´s urgency, the location of the
procedure, which sometimes takes place even outside the operation theatre, and also
due to conflicts emerging between the needs of the mother and fetus. The arising
maternal comorbidities such as obesity, contribute to complications in airway
management in this population.
Uterotonic Agents
Authors: Correa Barrera Juan José , Pulgar Vázquez Blanca Gómez del , Vinasco Adriana Orozco , Rodríguez Enrique Alonso
Published: December 2022

Postpartum haemorrhage due to uterine atony is one of the major causes of
maternal morbidity and mortality worldwide. Different control strategies have been
postulated, especially during the third stage of labour, but the gold standard treatment is
the use of uterotonic drugs. There are currently three well-defined groups of drugs:
oxytocics, ergot derivatives and prostaglandins. Although the literature is
heterogeneous, it is clear that oxytocin is the uterotonic of choice in both prophylaxis
and treatment of postpartum haemorrhage. Detailed knowledge of protocols based on
current evidence is mandatory, which vary according to the different medical societies
and dictate the doses and order of administration of different drugs.
Mindfulness-Based Interventions during Pregnancy and Labour
Authors: Sánchez Merchante Míriam , Martinez Hurtado Eugenio D.
Published: December 2022

During pregnancy, events occur that can negatively affect a woman's mental
health, such as vaginal bleeding, concern for the health of the fetus, decreased fetal
movements, ultrasound results, or fear of childbirth itself. Pregnant women must be
able to cope with these stressful events, as perinatal mental health problems can have
adverse consequences for both parents and babies.
Psychological disturbances in the mother during pregnancy can adversely affect the
development of the fetus, leading to long-term negative effects on the health of the
child. It is therefore important to identify prenatal interventions that can reduce this
maternal distress, and one possible approach to address these perinatal mental health
difficulties is mindfulness-based interventions.
IDENTIFIKASI Escherichia coli PADA AIR MINUM ISI ULANG
Authors: Sulistyani Nunung
Published: December 2022

Air memiliki peran penting bagi setiap makhluk hidup untuk memenuhi kebutuhan esensial. Asupan cairan dalam hal ini air minum menjadi sangat penting bagi tubuh manusia, maka perlu diperhatikan kualitas air minum sesuai standar yang telah ditetapkan. Saat ini, banyak penyelenggara air minum  isi ulang mendapatkan ijin operasi untuk memproduksi air minum bagi masyarakat. Untuk menjaga kualitas air minum yang dikonsumsi masyarakat, dilakukan pengawasan secara berkala baik secara internal maupun eksternal. Uji mikrobiologis dalam penelitian ini dilakukan pada air minum isi ulang “KHAIRA” Yogyakarta yang memberikan pelayanan air minum isi ulang dengan kualitas terjamin yang telah mendapatkan sertifikat laik higienis dari Dinas Kesehatan Kota Yogyakarta. Untuk itu perlu dilakukan pengawasan eksternal melalui penelitian ini, sehingga dapat dilakukan pengkajian kualitas air minum isi ulang Khaira melalui uji mikrobiologis. Penelitian ini dilakukan dengan melakukan identifikasi Escherichia coli pada air minum isi ulang. Data diperoleh melalui pemeriksaan air isi ulang menggunakan metode Most Probable Number (MPN). Hasil uji MPN menunjukkan tidak terdeteksi Escherichia coli pada semua sampel air. Kualitas air minum isi ulang yang diproduksi “Khaira” Yogyakarta berdasarkan uji identifikasi Escherichia coli memenuhi persyaratan batas cemaran mikroba
Изменение характеристик контактных пятен при протекании токов короткого замыкания через замкнутые сильноточные электрические контакты
Authors: Хрестин А.В. , Павлейно М.А. , Сафонов М.С.
Published: December 2022

Numerical simulation of heating of the vicinity of contact spots of closed copper high-current contacts by short-circuit currents of various shapes is carried out. The relationship between the parameters of thermal and mechanical fields when heated to temperatures exceeding the recrystallization temperature of the material is established. The dynamics of changes in the sizes of elastic and plastic deformations and their localization is shown. It is revealed in which cases the results of heating the contact surroundings may differ significantly with the flow of thermally equivalent currents.
Evaluation of OPTIMISE (Online Programme to Tackle Individual’s Meat Intake Through Self-regulation): Cohort Study
Authors: Stewart Cristina , Piernas Carmen , Frie Kerstin , Cook Brian , Jebb Susan A
Published: December 2022

Background

There is an urgent need to reduce society’s meat consumption to help mitigate climate change and reduce noncommunicable diseases.

Objective

This study aimed to investigate changes in meat intake after participation in an online, multicomponent, self-regulation intervention.

Methods

We conducted a pre-post observational study among adult meat eaters in the United Kingdom who signed up to a website offering support based on self-regulation theory to reduce meat consumption. The program lasted 9 weeks (including a 1-week baseline phase, a 4-week active intervention phase, and a 4-week maintenance phase), comprising self-monitoring, goal setting, action planning, and health and environmental feedback. Meat intake was estimated during weeks 1, 5, and 9 using a 7-day meat frequency questionnaire. We analyzed the change in mean daily meat intake from baseline to week 5 and week 9 among those reporting data using a hierarchical linear mixed model. We assessed changes in attitudes toward meat consumption by questionnaire and considered the acceptability and feasibility of the intervention.

Results

The baseline cohort consisted of 289 participants, of whom 77 were analyzed at week 5 (26.6% of the baseline sample) and 55 at week 9 (71.4% of the week 5 sample). We observed large reductions in meat intake at 5 and 9 weeks: –57 (95% CI –70 to –43) g/day (P<.001) and –49 (95% CI –64 to –34) g/day (P<.001), respectively. Participants’ meat-free self-efficacy increased, meat-eating identities moved toward reduced-meat and non–meat-eating identities, and perceptions of meat consumption as the social norm reduced. Participants who completed the study reported high engagement and satisfaction with the intervention.

Conclusions

Among people motivated to engage, this online self-regulation program may lead to large reductions in meat intake for more than 2 months, with promising signs of a change in meat-eating identity toward more plant-based diets. This digital behavior change intervention could be offered to complement population-level interventions to support reduction of meat consumption.
Effect of ferroptosis on infectious, inflammatory, and immune diseases is receiving attention: visualization and bibliometric analysis (Preprint)
Authors: Fang Hui , Xie Jun , Peng Jianxiang , Gong Xiaoling , Wang Youhua , Xie Yong
Published: December 2022

BACKGROUND

Ferroptosis is a novel type of programmed death that is gaining attention for its role in disease development. Recent research indicated that it is important in infectious, inflammatory, and immune diseases.

OBJECTIVE

This paper aims to examine global research trends in the relationship between ferroptosis and infectious, inflammatory, and immune diseases and generate new research ideas.

METHODS

This work aims to systematically discuss the “ferroptosis in infection, inflammation and immune diseases” research by bibliometric analysis. Documents were retrieved from the Web of Science Core Collection database on May 16, 2021. Statistical analysis and visualization analysis were conducted by the VOSviewer 1.6.18, and CiteSpace 5.8. R3 and Microsoft Excel 2019.

RESULTS

A total of 1109 publications on ferroptosis in infection, inflammation, and immune diseases publication were identified. The literature on this has grown since 2014 and will continue to a higher degree in the following years. China contributed the most significant proportion (68.62%) to ferroptosis publications. The keywords with the strong bursts were “apoptotic cell”, “autophagy”, “necroptosis”, “immune response” and “polyunsaturated fatty acids”. There are four main hotspots: ferroptosis and other programmed death: autophagy, apoptosis, and necroptosis, ferroptosis is involved in inflammatory diseases and immune infiltration, ferroptosis is applied to immunotherapy for tumors, and ferroptosis illuminates the prognosis of tumor treatment.

CONCLUSIONS

Ferroptosis in infectious, inflammatory, and immune diseases have received increased attention in recent years, with research focusing on the association with other programmed deaths, inflammatory diseases, immune infiltration, and immunotherapy for tumors and prognosis.
Nurses and care management in clinical emergencies: Bibliographic review
Authors: Assunção Letícia Almeida de , Costa Claudeth Freitas da , Monteiro Raimundo Lima , Uchôa Thaís Lopes do Amaral , Sousa Ralrizônia Fernandes , Melo Adriana Borges , Santos Eliana Maria dos , Braz José Carlos Nunes , Caldeira Priscila Morgana da Silva , Lago Sarah Jacqueline Costa do , Assunção Luana Priscila , Penha José Gustavo Monteiro , Costa Leonardo Silva da , Miranda Milton Nazareno de Quadros , Chagas Francielma Pinheiro das , Jacinto Regina Racquel dos Santos , Pereira Rogério Gomes , Magno João Victor Elyakim Pantoja , Oliveira Elane Magalhães , Guimarães Júlio Éliton Lima , Rupf Josiane Macedo de Oliveira , Silva Adams Brunno , Santos HioneTavares dos , Ribeiro Yasmin Pacheco , Rodrigues Thamyris Abreu Marinho , Castilho Carla Caroline Motta , Lemos Alda Lima , Souza Edioneise Dantas de , Silva Luceme Martins , Rodrigues Jhennifer Pereira , Ferreira Lucineia Ferreira , Martins Ana Caroline Guedes Souza
Published: December 2022

Objective: This study aims to gather, characterize, evaluate and integrate studies that investigated the management of nursing care in the main clinical emergencies. Method: This is a review of national and international literature, which includes the analysis of research results that offer support to nurses in relation to conduct in the main clinical emergencies. Results: Among the most cited clinical emergencies in the articles, the management of nursing care in hypertensive crisis, hyperglycemic crisis, upper and lower gastrointestinal bleeding, acute pulmonary edema, burn patients and sepsis stand out. Final considerations: The study had limitations regarding the number of scientific articles specifically related to urgency and nursing care. Furthermore, it is concluded that nurses play a fundamental role in the prevention, diagnosis, treatment, evolution and stabilization of the clinical picture.
Intelligence Network: Examine the competitive intelligence Network and its role on Organizational Performance
Authors: Ismail Zaid Saad , Jwmaa Swran Jawamir , Younus Saif Qudama , Othman Baban Jabbar , Rashad Muhammed Khazal , Kanabi Idrees Sadeq , Jamil Diyar Abdulmajeed , Mahmood Rozhgar Khorsheed
Published: December 2022

Over the past two decades, the fundamentals of organizations have undergone a tremendous shift due to changes and uncertainty. To remain competitive in the face of both internal and external challenges, organizations have begun to actively monitor their surroundings in order to better understand the possibilities and threats that exist in such settings. The purpose of this research is to examine the function of competitive intelligence networks in the decision-making processes of small and medium-sized enterprises (SMEs) in the Kurdistan area of Iraq. Researchers, however, used five variables of competitive intelligence networks (network extensiveness, third-party strategy, homophily, issue awareness, and promotion effort) to gauge the direct influence on company performance at SMEs. In addition, the investigation was able to delve into the oblique function of competitive intelligence networks by using them as a mediator between company performance and competitive intelligence. Researchers in the Kurdistan area of Iraq utilized hierarchical multiple regression and the Sobel test to examine the impact of a competitive intelligence network on the financial success of small and medium-sized enterprises. Five elements of a competitive intelligence network were used to quantify the direct effect on SME performance (extensiveness network, third-party strategy, homophily, issue awareness, and promotion effort). In addition, the researchers utilized the competitive intelligence network as a mediator to quantify its effect on company performance. This allowed the analysis to delve into the indirect influence of the competitive intelligence network. The following competitive intelligence network aspects were used to analyze the direct and indirect impact of competitive intelligence networks on SME performance: network extensiveness, third-party strategy, homophily, problem awareness, and promotional effort.
Poe’s “Metzengerstein” – Untangling the Skeins
Authors: Koshal Dr. Vikram Krishan
Published: December 2022

Poe’s “Metzengerstein” stands in a class of its own. It is first and foremost, a Gothic tale but, at the same time, it is much more as well. The Gothic mores embedded in the narrative are open to all the usual interpretations associated with Gothicism. Fear induced by the uncanny in the Freudian sense of unheimliche is an integral part of the text under consideration. What makes this tale special is the fact that the Gothic conventions have been used as an allegory for the decline and disintegration but ultimate vindication of creative imagination. The contemporary commodification of literature makes a writer’s journey a tight ropewalk as he traverses the precarious path marked by the breakdown of ‘Imagination’ in the Coleridgean sense of the term but culminating in its definitive exoneration. Viewed from a modern standpoint, “Metzengerstein” can be looked upon as a projection of Poe’s own fears and desires. It is also a repository of our apprehensions of being a ‘Doppleganger’.
Blockchain Based Payment Method for Secure Transactions
Authors: Hakke Harshad , Bharati Abhishek , Ranit Akshay , Khonde S R
Published: December 2022

Abstract: Blockchain is a type of distributed ledger that sits on the internet for recording transaction and maintaining a permanent and verifiable record-set of information. Token was created to reduce the government's control over cross-border transactions and to speed up the transaction process by removing the need for third-party intermediaries, Blockchain, on the other hand, provides a secure environment that token needs for peer-to-peer transactions. In other words, blockchain acts as bitcoin's ledger and maintains all the transactions of token. Token has a high degree of anonymity. Though the transactions are visible, it is close to impossible to identify the user. It is the purely peer-to-peer version of electronic cash would allow online payments to be sent directly from one party to another without going through a financial institution. Digital signatures provide part of the solution, but the main benefits are lost if a trusted third party is still required to prevent double spending or high security. We propose a solution to the double-spending problem
Predictive Analysis of Adverse Drug effects using Machine Learning
Authors: Sarde Atharva , Badgujar Mayur , Athayle Gargee , Sondkar Prof. Shilpa
Published: December 2022

Abstract: The objective of this work is to develop machine learning (ML) methods that can accurately predict adverse drug reactions (ADRs) using databases like SIDER (Side Effect Research) and OFFSIDES (Government medical records). In this paper, three Machine Learning algorithms SVM (Support Vector Machine), Random Forest, and Gradient boosted trees are implemented on the datasets to predict various disorders caused due to adverse effects, and the performance is evaluated based on performance metrics such as average precision, recall, accuracy, f1 binary, f1 macro, and f1 micro. Finally, the two datasets were merged to understand and compare the performance of a combined dataset to a single dataset.
Formulation and Evaluation of Mucoadhesive Bilayered Buccal Tablet of Ziprasidone Hydrochloride
Authors: Omer Mohammed , Shahidulla S.M.
Published: December 2022

The present project was carried out to formulate and evaluate the mucoadhesive bilayered buccal tablet of Ziprasidone Hcl. Ziprasidone HCl is an antipsychotic agent with half-life of about 2hrs and shows extensive metabolism i.e the drug concentration is < 5% after elimination in the body. The formulations (F1 to F6) were developed which comprises of polymers such as Hydroxypropyl methyl cellulose (HPMC K-15), Polyvinyl pyrollidine (PVP K-30) in various concentrations along with carbopol to achieve the desired characteristics. Mucoadhesive bilayered buccal tablets were fabricated with the aid of direct compression technique and the prepared formulation was evaluated for its physicochemical parameters along with evalauation test. The results from different evaluation test demonstrated that the formulation F1 containing HPMC (25 mg) and CP (10 mg) was selected as optimised formulation and result values of precompression parameters were within the limits and post compression results showed the mucoadhesive strength of F1 formulation was 25.27gm, the drug release at 8th hr was 85.7 % and the formulation was stable throughout the stability studies. Hence mucoadhesive bilayered buccal tablets of Ziprasidone HCl can be prepared. Based on the above results it can be stated that mucoadhesive bilayered buccal tablets can be successfully developed. Formulation described that the nature of tablet depends not only on the se lected polymer excipient but also on the concentration of polymers selected. 

Keywords:  Ziprasidone HCl, Bilayered Buccal Tablet, Mucoadhesion.
A Review on Ayurvedic Cosmeceuticals and their Mode of Actions
Authors: Hirudkar Vandana N. , Shivhare Vishal
Published: December 2022

The uses of herbal ingredients in cosmetic industry increases day by day since these products improves natural beauty and also gives anti-aging effect. The presence of chemicals such as essential oils, alkaloids, proteins, flavonoids, vitamins and minerals, etc., contributed towards the cosmeceutical properties of herbal cosmetics. Ayurveda described uses of cosmetic for retaining health of skin, hair and tooth, etc. The Ayurveda cosmeceutical provides Vayasthapana, Varnya, Sandhaniya, Tvachya, Shothahara and Tvachagnivardhani effects thus helps to retain beauty and resist symptoms of early aging. Natural products such as Amla, Gotukola, Neem, Henna, Bael, Brahmi, Haritaki, Shikakai, Bhringaraj and Reetha, etc. mainly used for the beautification purpose. Some Ayurveda formulations or topical preparations and oils also recommended for improving health of skin and hair. Ayurveda cosmeceuticals offers advantages of availability, safety and free from unwanted chemical reactions. Present article summarizes the key aspects related to the natural cosmeceuticals and their mode of action.

Keywords: Ayurveda, Beauty, Cosmeceuticals, Vayasthapana, Tvachya
Availability of Drugs for Mothers and Children in Community Health Centers in Commune VI of the Bamako Health District
Authors: TRAORE Sylvestre , COULIBALY Issa , TRAORE Mohamed dit Sarmoye , MALLE Fatoumata S , BAH Sekou
Published: December 2022

Introduction: Improving maternal and child health is a worldwide priority. An estimated 8.1 million children under five die each year. Approximately 1,000 women, most of whom live in developing countries, die every day from complications of pregnancy or childbirth. The objective of this work was to assess the availability of mother's and child's medicines at the level of the community health center VI of the Bamako district, Mali.

Materials and methods: This were a prospective cross-sectional study which was took place in Bamako in the community health center VI in 12 months over the period from November 2019 to October 2020. We carried out a survey in the 11 community health center VI. Data entry and analysis were performed using SPSS version 21.0 software.

Results: In this study, the sex ratio was 2.66. Half of the people surveyed were doctors (50%) who assumed the role of DTC (Technical Director of the Center). As for the profiles of managers, in our sample, accountants were the most represented with a rate of 31.82%. Almost all depot managers have received training in logistics management (86% of cases). 73.00% of Community health centers correctly followed the SDADME (drug supply and distribution master plan). The Community health centers were supplied by other suppliers in the event of a shortage at the PPM (Popular Pharmacy of Mali) with a rate of 86.40%. The total availability rate of medicines for mothers and children was 60%. Breaks were recorded for eight (08) products. The causes mentioned in relation to drug breaks were, among others: non-ordering of drugs, non-availability at the PPM and non-prescription of drugs by providers.

Conclusion: This study revealed a good availability of drugs for mother and child. However, we found that some of these drugs were out of stock. These shortages were due either to the non-availability of the PPM store, or to the non-ordering of these products by the Community health centers.

Keywords: management, medicine, CSComs, mothers and children, Bamako.
C-Reactive Protein (CRP) Medium and Severe Symptoms Levels of COVID-19
Authors: Manalu Erida , Winanda Adelia , Luhulima Danny Ernest Jonas
Published: December 2022

Coronavirus Disease 2019 (COVID-19) is a disease caused by SARS-CoV-2 and has caused a global pandemic. Patients with COVID-19 can experience symptoms such as fever, dry cough, headache, and shortness of breath which can lead to pneumonia. Excessive inflammation is considered a leading cause of critical illness and death in COVID-19 patients. C-Reactive Protein is a sensitive indicator as an early marker of infection and inflammation. This study presents an overview of the difference in the average CRP levels between patients with moderate and severe confirmed COVID-19 symptoms at UKI Hospital for June-September 2021. The study design was cross-sectional with descriptive and analytical data presentation obtained from medical record documents at UKI Hospital. The average CRP level of COVID-19 patients with moderate symptoms is 63,705 mg/L, totaling 139 patients. The average CRP level of COVID-19 patients with severe symptoms is 132,050 mg/L, totaling 57 patients. The results obtained from the Mann-Whitney test between groups of patients with moderate and severe COVID-19 showed a significant difference between CRP levels with moderate and severe symptoms with p <0.05.

Keywords: COVID-19, CRP levels, SARS-CoV-2
Contribution to the ethnobotanical and phytochemical study of Zanthoxylum zanthoxyloides (Lam.) Waterman (Rutaceae) from Mali
Authors: Cissé Salimatou , Somboro Aimé Anin , Cissé Mody , Bouaré Sékou , Tangara Ousmane , Dembélé Niaboula , Samaké Drissa , Togola Issiaka
Published: December 2022

Zanthoxylum zanthoxyloides (Lam.) Waterman (Rutaceae) is a tree from 5 to 15 m high that grows spontaneously in West Africa. It is frequently used in Malian traditional medicine for the treatment of various ailments. Thus, the present work is part of the development of this plant through an ethnobotanical survey and a phytochemical study of its leaves, stems and roots collected in Yanfolila and Ouélessébougou. The ethnobotanical survey showed that this species is used in the treatment of various pathologies such as tooth decay, toothache, throat, stomach and headaches, sickle cell anemia, sterility, cardiovascular diseases, edema, childbirth pains, and other diseases, sexual impotence, malaria, bilharzia, diabetes, hemorrhoids, dermatosis, constipation, fever, eye infections, dysentery. In most cases the preparation is done by decoction. The phytochemical screening showed the presence of coumarins, sterols and terpenes in the three investigated organs from the two sites. The alkaloids have been found in the roots and in the stems; the mucilages in all parts except in the roots of Yanfolila. The tannins are present everywhere except in the roots and in the stems of Yanfolila; flavonoids are present everywhere except in the stems of Yanfolila. The richness of the powder of these different organs in mineral elements such as calcium, iron, magnesium, sodium, potassium and copper was also highlighted.

Keywords: Zanthoxylum zanthoxyloides, ethnobotanical survey, phytochemistry, mineral elements
Floristic analysis of Medicinal Plants from the Sholas of Nilgiris, Tamil Nadu, India
Authors: Vishnu Kumar S , Danny Kingsley Jemima , Dharani S , Narayanan N , Thejan S.M.
Published: December 2022

Medicinal plant documentation is a wide field of research to identify the chronicle of indigenous knowledge about plant its usage and scientifically validating the valuable species. Several field trips were carried out in Nilgiri hills between September 2021 – January 2022, covering different seasons, in order to know the phenology of the plants, Intensive and extensive field surveys was done in and around villages in Coonoor and Ooty. A total of 42 plant species belonging to 28 families and 31 genera. The majority of the documented plants were climber (13), tree (9), herb (7), shrub (6) and twiner (1). The part of the plant most frequently used was the fruit (22) followed by leaves (13), root (3), tuber (2), rhizome and bark (1). The main uses of the herbal drug have been reported to have several medicinal importance such as anti-diabetic, anti-inflammatory, anti-tumour, gastric ulcer, skin disease, cancer, alzhimer disease, parkinsons, anti-hypertensive, hypolipidemic, antifungal, arthritis, rheumatism, lumbago, anti-asmatic, diuretic, anti-septic, anti- analgesic, anti-proliferative, sedative, anti-microbial, antipyretic, anthelmintic. During this survey documentation of medicinal plants seems to be identified to have high medicinal importance. Cayratia pedata, Fragaria nilgerrensis, Syzygium densiflorum and Syzygium grande are some of the very commonly used medicinal plants. There is a need to document the threats which increase biotic interference and climatic change there is an urgent need to create awareness among the local people for the sustainable utilization as well as conservation of these medicinal plants in their original habitat.
Keywords: Documentation, Nilgiris, Medicinal Plants, Utilization
Dependência versus autonomia no envelhecimento: sob a luz da Psicanálise
Authors: Boufleuer Teresinha Rita , Maria Pandolfi Koch Hack Soraya , Felipi Elizangela
Published: December 2022

Introdução: O aumento da geração idosa demanda atenção para estados psíquicos e para patologias próprias da longevidade. A expectativa de vida longa aumenta a consciência das perdas decorrentes dos processos degenerativos do corpo e de condições sociais conquistadas na vida adulta. Ao mostrar que o inconsciente não envelhece, a Psicanálise qualifica a escuta, adequando métodos de análise nesta população. Objetivo: Compreender o envelhecimento humano no que se refere aos processos de dependência progressiva versus luta pela autonomia, explicitando contribuições da clínica psicanalítica com adultos maduros. Metodologia: O estudo qualitativo, de caráter bibliográfico e filmográfico, baseia-se na teoria de desenvolvimento e amadurecimento infantil de Winnicott, considerando “dependência absoluta, dependência relativa e rumo à independência”. A discussão atualizada é ilustrada com diálogos entre os personagens da minissérie “Meu amor: seis histórias de amor verdadeiro”. Resultados: A partir de contribuições de autores contemporâneos sobre a clínica com idosos, reflete-se que um adulto que conquistou patamares importantes de independência e autonomia, a depender das suas condições de saúde e ambiente em que vive, pode retornar para um estado de dependência relativa e absoluta. Considerações finais: Percebem-se gradativas mudanças nas concepções sobre o envelhecimento e, para além de limitações e patologias, vê-se os idosos com direitos e potencialidades. Estima-se que a ampliação de estudos sobre o adulto maduro contribua para a atualização de práticas na atenção à saúde mental, considerando o envelhecimento como um período de investimento libidinal.
Organizational and societal goals in tension? A survey of communication practitioners at Swiss higher education institutions
Authors: Fürst Silke , Volk Sophia Charlotte , Schäfer Mike S. , Vogler Daniel , Sörensen Isabel
Published: December 2022

The public communication of higher education institutions (HEIs) has gained importance both in practice and research and can serve different goals. Many scholars argue that HEI communication departments mainly aim to promote their organization and are less concerned with broader societal goals and normative principles of communication. Since these assumptions have not yet been explored empirically, we surveyed 203 communication practitioners from all 42 Swiss HEIs on their role conceptions and the quality criteria used in their communication departments. Our results show no general dominance of organizational over societal goals and revealed few differences between different types of HEIs.
Ēdiens kā sociālo pārmaiņu liecinieks dzīvesstāstos un jaunākajā latviešu prozā (20. gadsimta 80./90. gadu mija)
Authors: Kalniņa Ieva , Kursīte Elīna
Published: December 2022

Ēdiens ir sociālo pārmaiņu marķieris. Proza par jauno gastronomisko pieredzi ironizē un sakāpina to līdz hiperbolai, bet ēdienu izvēles lietišķais apraksts tuvojas dzīvesstāstam
Agama, Covid-19, dan Tatanan Budaya Baru: Pengabdian Kalangan Muda NU Soloraya terhadap Pandemi Covid-19
Authors: Mibtadin Mibtadin , Masamah Ulfa , Fatimah Lilis
Published: December 2022

Covid-19 emerged in early 2020 until now its spread has not been able to be stopped and changed the order of life, including religion. This article captures the role of NU Soloraya's young people in responding to the spread of Covid-19. This devotion is descriptive qualitative and uses a sociology of religion approach. The young people of NU Soloraya responded to providing spiritual guidance and encouraged pilgrims to actively develop a theology of moderation, namely a theology of concern for others that is manifested in the spirituality of humanity. They position themselves as facilitators, animators, enablers, catalysts so that they can become opinion leaders and balance discourse about Covid-19. With empathy, sympathy, and concern, they strengthen social resilience so that the network of taklim majlis and pesantren becomes social capital to overcome Covid-19.
Permainan Tradisional untuk Mengatasi Adiktif Gawai pada Anak di Desa Alastuwo
Authors: Joni Rusdiana  , Putri Haura Sabita
Published: December 2022

The recommendation of the PPPA Ministry is that children should ideally be allowed to use gadgets after they are at least 13 years old. However, the fact is that in Alastuwo Village, Kebakkramat, Karanganyar, many children under the age of 13 are addicted to gadgets. For this reason, the UIN Raden Mas Said Surakarta service team intends to provide a solution to this problem through a traditional game outreach program. The method used is Participatory Action Research (PAR) by actively participating in activities with the subject of Alastuwo Village children who are studying from kindergarten to elementary school. There are three types of games that we socialize. They are jumping rope, marbles, and gobak sodor. This program shows positive results, that are evidenced by the reduced frequency and intensity of using gadgets in children. In addition, this game is also continuously repeated by children in the following days along with peers. We hope that this program can be recommended and carried out in other areas experiencing similar problems, both with the same game and other types of traditional games.
Mediterranean intermittent rivers and ephemeral streams: temperature and water level responses to precipitation events
Authors: Galea Alexander Borg , Hannah David , Galdies Charles , Sadler Jon
Published: December 2022

Despite continued interest in flow regime variability and its influence
on stream dynamics in intermittent rivers and ephemeral streams, the
link between different precipitation events and its control on water
presence in hydrologically transient catchments with varying land cover
and biophysical characteristics, has rarely been studied. This paper
presents the results from high-resolution (30-min) precipitation data
and streambed temperatures collected from a fifteen-month period from
six different Mediterranean intermittent and ephemeral catchments. The
monitoring timeframe proved to be one of the driest periods in the
studied areas in the last 50 years and most recorded rain events were
small, the majority of which not exceeding 0.4mm of rainfall in a single
event. The results demonstrate the larger studied catchments had longer
water level response lag times to precipitation episodes. In addition,
reduced water level responses to autumn rain events in rural areas
indicated that the soil water retention capacity due to the limited soil
moisture content during the summer period and the empty water-retention
infrastructure, play an important role in governing flow presence. The
smaller and predominantly urban catchment, resulted with the second most
rapid water presence response times and the highest average streambed
temperature peaks following precipitation events. Conversely, rural
catchments that have groundwater springs contributing to stream flows,
showed more stable temperature variations. This research highlights the
need for the improved understanding of the intrinsic landscape and basin
properties that control the spatio-temporal patterns of transient flows
and thermal responses to varying rain events, especially in a changing
climate.
In-plane Mesoporous MXene Nanocomposite Electrodes: Maximizing Ion Accessibility/Transport Pathway and Mechanical Strength of Pristine MXene
Authors: Zhang Yuhang , Wang Yongxin , Cheng Yongfa , Ma Yanan , Wang Mengjie , Wei Zhichao , Li Ao , Cheng Feng , Ge Binghui , Wang Shiliang , Yue Yang
Published: December 2022

Developing electrode materials with mechanical integrity and high
electrochemical performance applied for flexible electronic devices
remains a great challenge. This work reports a porous MXene/aramid
nanofiber (ANF) electrode material. The introduction of mesopores and
reduced lateral sizes in the plane of MXene nanosheets provides lots of
active sites and ion transport channels. Moreover, the addition of ANF
as an intercalator enlarges the interlayer spacing, which also acts as
an interlocking agent to form hydrogen bonds to connect the nanosheets,
while endowing the super mechanical strength. In addition, zinc ion
microcapacitors (ZIMC) are built with the electrode material, which
exhibited high specific capacitance of 207 mFcm-2 at a scan rate of 5
mVs-1. It shows a high energy density of 109.6mWhcm-2 at a power density
of 4200mWcm-2. The integrated pressure sensing device powered by this
ZIMC demonstrates good promise for use in the field of detection of
human motion signal.
Spineless and overlooked: DNA metabarcoding of Autonomous Reef Monitoring Structures reveals population genetic structure in Mediterranean invertebrates
Authors: Thomasdotter Anna , Shum peter , Mugnai Francesco , Vingiani Marina , Abbiati Marco , Costantini Federica
Published: December 2022

The ability to gather genetic information from organisms obtained
directly from environmental samples is crucial to determine biodiversity
baselines and understanding population dynamics in the marine realm.
While DNA metabarcoding is effective in evaluating biodiversity at
community level, genetic patterns within species are often concealed in
metabarcoding studies and overlooked for marine invertebrates. In the
present study, we implement recently developed bioinformatics tools to
investigate intraspecific genetic variability for invertebrate taxa in
the Mediterranean Sea. Using metabarcoding samples from Autonomous Reef
Monitoring Structures (ARMS) deployed in three locations, we present
haplotypes and diversity estimates for 145 unique species. While overall
genetic diversity was low, we identified several species with high
diversity records and potential cryptic lineages. Further, we emphasize
the spatial scale of genetic variability, which was observed from
locations to individual sampling units (ARMS). We carried out a
population genetic analysis of several important yet understudied
species, which highlights the current knowledge gap concerning
intraspecific genetic patterns for the target taxa in the Mediterranean
basin. Our approach considerably enhances biodiversity monitoring of
charismatic and understudied Mediterranean species, which can be
incorporated into ARMS surveys.
Recurrent malignant peritoneal mesothelioma treated by a second resection: A case report
Authors: Miyata Takashi , Nishiki Hisashi , Shinden Yuki , Motoyama Shota , San-nomiya Yuta , Tamezawa Hozumi , Nagayama Taigo , Kin Ryosuke , Hashimoto Akifumi , Kaida Daisuke , Tomita Yasuto , Nakamura Naohiko , Miyashita Tomoharu , Fujita Hideto , Ueda Nobuhiko , Takamura Hiroyuki
Published: December 2022

Malignant peritoneal mesothelioma, a rare disease with a very poor
prognosis, is seldom treated surgically, especially for recurrence.
However, early diagnosis and aggressive treatment of primary and
recurrent tumors, particularly the localized type of malignant
peritoneal mesothelioma, can achieve long-term patient survival.