bluuebunny/crossref_metadata_2025 huggingface dataset:
دور المصارف الإسلامية الفلسطينية في تنمية النشاط الاقتصادي وتركزات استخدام أدوات التمويل القائمة على مفهوم الملكية والمديونية
Authors: Awadh Azmi
Published: December 2019

تهدف الدراسة إلى التعرف على دور المصارف الإسلامية الفلسطينية في تنمية النشاط الاقتصادي، وبيان تركزات استخدام المصارف الإسلامية الفلسطينية لأدوات التمويل الإسلامية القائمة على مفهوم الملكية والمديونية، وما مدى توزيع التمويلات الممنوحة من قبل المصارف الإسلامية الفلسطينية على مختلف القطاعات الاقتصادية لدفع عجلة التنمية في فلسطين ، وقد خلصت الدراسة إلى أهمية الدور الذي تؤديه المصارف الإسلامية في تمويل التنمية من الناحية النظرية، غير أن النتائج التحليلية لدور المصارف الإسلامية الفلسطينية في تنمية النشاط الاقتصادي أكدت أنها دون التوقعات والمستوى المطلوب، وأن دورها لم يكن فاعلاً بالمقارنة مع مستوى النجاح الذي حققته في تجميع المدخرات، وأن النتائج أظهرت أيضاً عدم توزيع التمويلات الممنوحة من قبل المصارف الإسلامية الفلسطينية على مختلف القطاعات الاقتصادية بشكل متوازن،كما أن الدراسة أظهرت أن المصارف الإسلامية ركزت في استخداماتها على أدوات التمويل الإسلامية القائمة على مفهوم المديونية ، وبالأخص على أداة المرابحة للآمر بالشراء ، وأهملت جزئياٌ أدوات التمويل القائمة على مفهوم الملكية ، مما أضعف دورها في تحقيق التنمية الاقتصادية ، وقد قدم الباحث العديد من التوصيات حول تنشيط الدور التنموي للمصارف الإسلامية الفلسطينية.
التَأييدَات العَلِيةُ، للأوقَاف المِصْريَة
Authors: Al Jumaili OMAR
Published: December 2019

يعالج البحث مشكلة تاريخية تتكرر على مر الأزمان، ألا وهي الاعتداء المتكرر على الأموال الوقفية، حيث تم الاعتداء على الأموال الوقفية في القاهرة، فجاءت هذه الرسالة للإمام نَجم الدِين مُحمد بن أحمَد بن عَلي الغَيطِي (ت981هـ)، لرد تلك الشبهات وإحقاق الحق، وكان هدف الباحث وراء إخراج هذه الرسالة الهامة التي عالجت أمراً مشكلاً تَعَلَقَ بإهدار المال العام، هو إلفات نظر الباحثين إلى ضرورة إخراج ذلكم التراث النافع، وهي من ناحية أخرى تدعو الى صيانة الأموال الوقفية وعدم المساس بها، وقد خلص البحث إلى أن المال الوقفي هو محتاج الآن أكثر من أي وقت مضى إلى مزيد من الرعاية والصيانة والاستثمار، كما يوصي الباحث بالاهتمام بتراث الأمة الذي يمس حاجاتها الآنية. الكلمات المفتاحية: أوقاف، الأراضي الوقفية، أوقاف مصر
معالجة الكفارات الشرعية لمشكلة الفقر
Authors: Babakr Mohammed
Published: December 2019

يسعى البحث إلى بيان الكيفية التي تتم عن طريقها معالجة الكفارات الشرعية للفقر ومن ثم التعرف على الآثار الاقتصادية للكفارات . وتبرز أهمية البحث من جهتين تفاقم مشكلة الفقر والضرورة الملحة للاستفادة من الكفارات . يهدف البحث إلى استجلاء آثار تطبيق الكفارات على مشكلة الفقر وقدرتها على ذلك يفترض البحث قدرة الكفارات الشرعية على التخفيف من مشكلة الفقر ، تنوع الكفارات يمكن الفقراء من سد حاجاتهم المتعددة . يتبع البحث المنهج التحليلي والاستقرائي ، وذلك من خلال حصر أقوال الفقهاء في المسالة الواحدة وتحليل ذلك اقتصادياً، يتكون البحث من مقدمة وثلاثة مباحث أولها : الكفارات – أنواعها وأحكامها وثانياً : كيفية تأثير الكفارات في دفع الفقر وثالثها : الآثار الاقتصادية للكفارات . الكلمات المفتاحية: الكفارات ، اليمين ، الفقير
Effect of DNA Extraction Methods on the Apparent Structure of Yak Rumen Microbial Communities as Revealed by 16S rDNA Sequencing
Authors: CHEN YA-BING , LAN DAO-LIANG , TANG CHENG , YANG XIAO-NONG , LI JIAN
Published: December 2019

To more efficiently identify the microbial community of the yak rumen, the standardization of DNA extraction is key to ensure fidelity while studying environmental microbial communities. In this study, we systematically compared the efficiency of several extraction methods based on DNA yield, purity, and 16S rDNA sequencing to determine the optimal DNA extraction methods whose DNA products reflect complete bacterial communities. The results indicate that method 6 (hexadecyltrimethylammomium bromide-lysozyme-physical lysis by bead beating) is recommended for the DNA isolation of the rumen microbial community due to its high yield, operational taxonomic unit, bacterial diversity, and excellent cell-breaking capability. The results also indicate that the bead-beating step is necessary to effectively break down the cell walls of all of the microbes, especially Gram-positive bacteria. Another aim of this study was to preliminarily analyze the bacterial community via 16S rDNA sequencing. The microbial community spanned approximately 21 phyla, 35 classes, 75 families, and 112 genera. A comparative analysis showed some variations in the microbial community between yaks and cattle that may be attributed to diet and environmental differences. Interestingly, numerous uncultured or unclassified bacteria were found in yak rumen, suggesting that further research is required to determine the specific functional and ecological roles of these bacteria in yak rumen. In summary, the investigation of the optimal DNA extraction methods and the preliminary evaluation of the bacterial community composition of yak rumen support further identification of the specificity of the rumen microbial community in yak and the discovery of distinct gene resources.
Effect of antibiotics on polymorphonuclear leukocyte functions and myeloperoxidase activity, glutathione and malondialdehyde levels in allergic asthma
Authors: RAYAMAN PERVİN , RAYAMAN ERKAN , ÇEVİKBAŞ ADİLE , DEMİRTUNÇ REFİK , ÖZER ŞEHİRLİ AHMET , ALAGÖZ ŞEYDA GÜL , GÜRER ÜMRAN SOYOĞUL
Published: December 2019

We investigated the effect of ciprofloxacin, rifampicine and doxycycline on myeloperoxidase (MPO) activity, glutathione (GSH) and malondialdehyde (MDA) levels in allergic asthma patients and healthy volunteers. Polymorphonuclear leukocytes (PMNs) were isolated with ficoll-hypaque gradient centrifugation method. MPO activity was assayed with modified o-dianisidine, GSH by Ellman's and MDA levels by Beuge's method. PMN functions and MDA levels of patients significantly decreased when compared with healthy volunteers. Ciprofloxacin significantly increased PMN functions, MPO activity and MDA levels of both groups. We have demonstrated that ciprofloxacin has beneficial effects on MPO activity and PMN functions in allergic asthma patients and healthy volunteers.
Characteristics of the Pseudomonas aeruginosa PA01 intercellular signaling pathway (Quorum Sensing) functioning in presence of porphyrins bismuth complexes
Authors: GALKIN MYCOLA , IVANITSIA VOLODIMIR , ISHKOV YURIY , GALKIN BORIS , FILIPOVA TETIANA
Published: December 2019

The influence of synthetic and natural porphyrins bismuth complexes on P. aeruginosa quorum sensing system was carried out by detection of the pyocyanin, rhamnolipids and autoinducers biosynthesis level. The highest ability to reduce pyocyanin biosynthesis showed Bi(III)-TPP. Rhamnolipids production level also decreased in the presence of studied compounds. This effect was the most expressed in presence of 40 and 80 µM of the synthetic meso-substituted porphyrins. Autoinducers biosynthesis, especially 3-oxo-C12-HSL was suppressed in presence of the bismuth complexes. That suggest that the mechanisms of action of this substances is an inhibition of signaling molecules or/and receptor for them.
Immunomodulatory effect of β-glucan on peritoneal macrophages of Babl/c mice
Authors: ROUDBARY MARYAM , DANESHMANDI SAEED , HAJIMORADI MONIRE , ROUDBARMOHAMMADI SHAHLA , HASSAN ZUHAIR M.
Published: December 2019

We assessed the effect of β-Glucan on macrophages by Griess reagent and viability by MTT assay and cytotoxicity. Assay of macrophages culture supernatants were carried out on WEHI-164 fibrosarcoma cell line as tumor necrosis factor-α bioassay were done. NO release was increased at the dose of 10 µg/ml (P = 0.001) of β-Glucan while the viability of macrophages in all concentrations was the same. In TNF-α bioassay, the supernatant of macrophages stimulated with β-Glucan had a significant cytotoxic effect on WEHI-164 cells (P = 0.023). β-Glucan had a positive effect on increasing tumoricidal activity of macrophages which may help in anti-cancer immune responses.
KAJIAN HUBUNGAN KUAT LENTUR DENGAN KUAT TEKAN BETON
Authors: Suhendra Suhendra
Published: December 2019

Currently, rigid pavement in almost all national, provincial and district roads is used instead of flexible pavement. One of the rigid concrete pavement quality controls is the flexural strength (fr = 45 kg / cm2 at 28 days) as stated in the General Specification of Binamarga year 2010 revision 3. This specification no longer regulates the value of compressive strength of the rigid pavement. This is a challenge for the construction’s practicians in implementation of the specification, because during this time the procurement of cement concrete is based on the compressive strength. The formula is in SNI 2847: 2013 on concrete that fr = 0,62Öfc’. While the construction practitioners generally still use the binamarga specifications of previous revisions that contain the quality of concrete (K-350), so that the quality of bending in general is not achieved. This research covers the value of bending test results conducted in the Engineering Laboratory on beams provided by third parties using lab services, as well as test specimens made in the laboratory. The test results show that there is a correlation between the flexure strength to the compressive strength of the concrete. The relationship is more or less the same as the formula contained in SNI concrete.Keywords: Concrete, Flexure strength, compressive strength, Binamarga Specs 2010 rev. 3
PENGARUH PENAMBAHAN SERAT GONI TERHADAP KUAT TEKAN DAN KUAT TARIK BETON
Authors: Nuklirullah M
Published: December 2019

Concrete has less good properties, ie brittle so it is not strong enough to withstand tensile. To overcome the bad nature of the concrete can be done by adding fiber (fiber) on the concrete mix. The goal is to reinforce concrete with fiber that is spread uniformly into a concrete mix. The commonly used fibers are made of steel, polymer, or glass fiber. One type of fiber that can be used is roselle fiber which is the material of the burlap maker which belongs to the category of natural fiber. This research was conducted with the aim to know the compressive strength and tensile strength of concrete due to the influence of the addition of jute fiber. Variation of mixed fiber used is 0%, 1% and 3%. The test specimens were used in the form of a cylinder with a diameter of 15 cm and a length of 30 cm for a compressive strength test of 3 pieces and a tensile strength test of 3 pieces for each variation of the jute fiber mixture used. The results showed that with the addition of jute fiber decreased the value of workability. The unit weight of concrete decreases with increasing fiber content. Concrete strength and concrete tensile strength decrease with increasing jute fiber.Keywords: Concrete, Fiber, Compressive Strength, Tensile Strength
Perencanaan Tebal Lapis Perkerasan Kaku pada Tanah Lunak di Jalan Antar Kota Menggunakan Metode AASHTO Tahun 1993
Authors: Febriani Ditty Trianita
Published: December 2019

Penelitian ini bertujuan untuk mengetahui perencanaan tebal lapis perkerasan kaku pada tanah lunak dengan metode AASHTO 1993 dan membandingkan perencanaan tebal lapis perkerasan kaku pada tanah lunak dengan perencanaan dan perhitungan tebal lapis perkerasan kaku pada tanah yang tidak lunak. Berdasarkan hasil analisis Tebal Lapis Perkerasan kaku menggunakan metode AASHTO untuk tanah lunak dengan CBR 2,83% adalah 11,42 Inchi atau 29 cm. Rincian sebagai berikut Lebar Pelat = 2 x 3,5 m, Panjang Pelat = 5,5 m, Dowel bars digunakan Ø32 mm, panjang 45 cm, dan jarak 300 mm, Tie Bars digunakan Ø16 mm, panjang 80, dan jarak 600 mm, Mesh Bars digunakan Ø12 mm dan jarak 200 mm. Tebal Lapis Perkerasan  kaku menggunakan metode AASHTO untuk tanah lunak dengan CBR 2,83% adalah 11,42 Inchi atau 29 cm. Sementara tebal Lapis Perkerasan  kaku menggunakan metode AASHTO untuk tanah tidak lunak dengan CBR 6% adalah 11,02 Inchi atau 28 cm. Jadi, CBR tanah dasar sangat mempengaruhi tebal lapis perkerasan kaku. Sebagai tambahan tanah lunak pada dasarnya mudah mengalami lendutan sehingga untuk mengantisipasi hal tersebut dibutuhkan pemasangan besi tulangan.
THE ROOT CAUSES AND NEXUS OF MILITANT ISLAMIC MOVEMENTS IN INDONESIA: CASE STUDIES OF DARUL ISLAM AND JEMAAH ISLAMIYAH
Authors: Yunanto Sri , Damayanti Angel
Published: December 2019

Many scholars believe that every religion has its peaceful interpretation as well as violent practices. Yet, this article elaborates more on the Islamic radical movements in Indonesia, particularly on the questions of what factors have triggered them to conduct such violence, how they linked each other and what action should be taken by the Indonesian government to counter-terrorism. To answer the question, the paper will focus on the ideology part and organization network of Darul Islam (DI) and Jemaah Islamiyah (JI), which shared similar ideology, network and methods of recruitment. Authors argue that ideology and organization become vital elements for DI and JI, in which the government, coupled with all stakeholders, should pay more attention if they want to eradicate violence in the name of religion. Although there is â€œno prescription fits allâ€ in eradicating terrorism, the ability to understand the root causes and organization network of terrorism in Indonesia will help the government and all stakeholders to establish a proper strategy.

 

Key words: Counter-terrorism, salafi jihadism, Darul Islam, Jemaah Islamiyah

 

 

Abstrak

 

Banyak pengamat percaya bahwa setiap agama mengandung interpretasi damai sekaligus juga tindak kekerasan. Namun, artikel ini akan mengulas lebih banyak tentang gerakan radikal Islam di Indonesia, terutama yang terkait dengan faktor-faktor apa saja yang mendorong mereka melakukan aksi kekerasan, bagaimana kelompok-kelompok tersebut saling memiliki keterkaitan dan tindakan apa yang perlu diambil oleh pemerintah Indonesia dalam melakukan kontra-terorisme. Untuk menjawab pertanyaan tersebut, paper ini akan menjelaskan ideologi dan jaringan organisasi dari Darul Islam (DI) dan Jemaah Islamiyah (JI), di mana keduanya memiliki kemiripan termasuk juga dalam metode rekrutmen. Penulis berpendapat bahwa ideologi dan organisasi merupakan elemen penting bagi DI dan JI. Oleh karena itu, pemerintah dan seluruh elemen masyarakat harus memperhatikan hal ini jika ingin memberantas kekerasan atas nama agama. Walaupun tidak ada â€œresep ampuhâ€ yang dapat mengatasi terorisme, kemampuan untuk memahami akar permasalahan dan jaringan organisasi kelompok terorisme di Indonesia akan membantu pemerintah dan seluruh elemen masyarakat untuk menyusun strategi yang tepat.

 

Kata Kunci: Counter-terrorism, salafi jihadisme, Darul Islam, Jemaah Islamiyah
PROYEKSI INDONESIA BERGABUNG DALAM TRANS-PACIFIC PARTNERSHIP
Authors: Maya Arthuur Jeverson
Published: December 2019

This article discusses the projection high standard free trade cooperation of the Trans-Pacific Partnership (TPP) which attracts Indonesia to join under President Joko Widodo (Jokowi). It is analyzed predictively calculation of the situation that occurred if Indonesia was determined to join TPP in the future. This is analyzed using the concept of political communication, the concept of neoliberalism, and the critical theory of neomarxism, supported by qualitative research methods and data collection from secondary sources. Found evidence indicating the inability of Indonesia's competitiveness against majority member states of TPP. As a result, they have the potential to engage in exploitative, dependent, and monopoly relationships with Indonesia's economic and social if join TPP at this time. Therefore, it is recommended to reject TPP until Indonesia has the optimal competitiveness ability to refer to the effectiveness, efficiency, and productivity of the population, low poverty, high gross national income percapita, high value human development index, high value global competitive advantage, anti-corruption business bureaucracy, and adequate infrastructure.

Keywords: Trans-Pacific Partnership (TPP), Indonesia, Neoliberalism, Neomarxism

 

 

Abstrak

 

Artikel ini membahas proyeksi kerja sama perdagangan bebas berstandar tinggi Trans-Pacific Partnership (TPP) yang menarik minat Indonesia dibawah kepemimpinan Presiden Joko Widodo (Jokowi) untuk bergabung di dalamnya. Ia dianalisis prediktif mengenai kalkulasi situasi yang terjadi apabila Indonesia nekat bergabung dalam TPP di masa depan. Ini dianalisa menggunakan konsep komunikasi politik, konsep neo-liberalisme, dan teori kritis neo-marxisme, didukung metode penelitian kualitatif dan pengumpulan data dari sumber sekunder. Ditemukan bukti-bukti yang mengindikasikan ketidakmampuan Indonesia bersaing dengan mayoritas negara-negara anggota TPP. Akibatnya, mereka berpotensi melakukan hubungan eksploitatif, ketergantungan, dan monopoli ekonomi dan sosial indonesia jika memutuskan bergabung dalam TPP saat ini. Oleh sebab itu, direkomendasikan untuk menolak TPP sampai Indonesia memiliki kemampuan daya saing optimal mengacu efektivitas, efisiensi, dan produktifitas populasi, kemiskinan rendah, pendapatan nasional perkapita tinggi, indeks pembangunan manusia tinggi, keunggulan nilai dalam menghadapi persaingan global, birokrasi bisnis anti-korupsi, dan infrastruktur yang memadai.

 

Kata Kunci: Trans-Pacific Partnership (TPP), Indonesia, Neoliberalisme, Neomarxisme
EKSISTENSI JEPANG DAN TIONGKOK DALAM GEOPOLITIK ENERGI DI ASIA TENGAH
Authors: Suhartini Ayu , Pratiwi Dian Permata , Sudarno Jorshy Amanda , Siregar Paulus Anggiat , De Queljoe Shybill Natalia , Geyasra Syahrir Roni
Published: December 2019

Abstract

In addition to its existence stretching along Silk Road between Europe and East Asia which later made it theheart of Euroasia, the Central Asia region is also a region rich in energy resources, specifically oil and naturalgas. These two factors then brought the region of Central Asia to develop into the second largest oil and gasproducing region in the world, after the Middle East. This makes the Central Asian region as an arena as well asa battle theater for energy interests between western countries, Russia, China, Japan, South Asian countries andthe Middle East. Japan and China particulary, in the past decade began to show their interest and concentrationin this region. This can be seen through the establishment of the 2004 Central Asia Plus Japan Dialogue and the2006 Official Development Assistance (ODA) by Japan. Do not want to fall behind, in 2013 through itsPresident, Xi Jinping, China building the cooperation with the Central Asia through the One Belt One Road(OBOR) initiative. The purpose of this paper is to explain how the existence of Japan and China and theirinfluence in the dynamics of geopolitical energy in the Central Asian region. To complete this paper, the authorused qualitative research methods. From this paper, it was found that the existence of Japan and China hadpositive impact on the dynamics of energy geopolitics in the Central Asia region.

Keywords: Geopolitical energy, oil, natural gas, Japan, China, Central Asia.

 

Abstrak

Selain keberadaannya yang terbentang di sepanjang Silk Road antara Eropa dan Asia Timur sehinggamenjadikannya jantung dari Euroasia, Asia Tengah juga merupakan wilayah yang kaya akan sumber daya energiterutama minyak dan gas alam serta penghasil terbesar kedua di dunia setelah Timur Tengah. Hal ini membuatkawasan Asia Tengah sebagai arena sekaligus teater pertempuran kepentingan energi antara negara-negara barat,Rusia, Tiongkok, Jepang, negara-negara Asia Selatan dan Timur Tengah. Jepang dan Tiongkok secara khususdalam dekade terakhir mulai menunjukan minat dan konsentrasinya pada kawasan ini. Terbukti melaluipembentukan Central Asia Plus Japan Dialogue tahun 2004 dan Official Development Assistance (ODA) tahun2006 oleh Jepang. Tidak ingin ketinggalan pada tahun 2013 melalui Presidennya, Xi Jinping, Tiongkokmembangun kerjasama melalui inisiatif One Belt One Road (OBOR). Adapun tujun dari tulisan ini adalah untukmenjelaskan bagaimana eksistensi dan pengaruh dari keberadaan Jepang dan Tiongkok dalam dinamikageopolitik energi di kawasan Asia Tengah. Dalam menyelesaikan tulisan ini, penulis menggunakan metodepenelitian kualitatif. Dari tulisan ini didapatkan bahwa keberadaan Jepang dan Tiongkok cukup memberikanpengaruh positif bagi dinamika geopolitik energi di kawasan Asia Tengah.

Kata Kunci: Geopolitik energi, minyak bumi, gas alam, Jepang, Tiongkok, Asia Tengah
15 rokov v Európskej únii: aktuálne otázky a súčasné výzvy
Authors: Miháliková Valéria
Published: December 2019

V prvom polroku tohto roku sa v Košiciach uskutočnila vedecká konferencia: „15 rokov v Európskej únii: aktuálne otázky a súčasné výzvy“, príspevky z ktorej sú obsiahnuté v predkladanom rovnomennom Zborníku. Zámerom jej tradičného organizátora tj. UPJŠ v Košiciach, Právnická fakulta, Ústav medzinárodného práva a európskeho práva bolo tematicky nadviazať na predošlú konferenciu z r. 2014 „10 rokov v EÚ - Vzťahy, otázky, problémy“ a s odstupom piatich rokov opäť poskytnúť záujemcom priestor na analýzu a výmenu názorov na problémy späté s vplyvom a uplatňovaním ako úniového práva v Slovenskej republike tak aj s aktuálnymi výzvami, ktoré prinieslo úniové právo v období posledných piatich rokov. Obsahovo a tematicky rôznorodé príspevky skúmajú vzťah úniového práva a vybraných ustanovení Ústavy Slovenskej republiky, aktuálne problémy prejudiciálnych otázok v činnosti Ústavného súdu Slovenskej republiky a úlohu úniového práva v konaní o súlade právnych predpisov, pričom v pomerne značnom počte skúmajú autori príspevkov vplyv úniového práva na vybrané oblasti slovenského právneho poriadku napr. v oblasti audiovizuálnych mediálnych službách, procesných práv jednotlivca v oblasti environmentálnych práv, v práve obchodných spoločností, konkurzného práva, trestného práva, ochrany ľudských práv a i.. Z príspevkov zahraničných účastníkov možno spomenúť ten, ktorý je venovaný európskej legislatíve v praxi českej Poslaneckej sněmovne. Po tretej “päťročnej“ konferencii venovanej úniovému právu jej organizátori s potešením konštatujú rastúci záujem akademickej obce o problematiku úniového práva a predovšetkým jeho vplyvu na vnútroštátne právne poriadky jednotlivých štátov. Rastúci záujem o túto tému sa neprejavil len v počte prednesených príspevkov, ale aj vo vysokej odbornej úrovni ich spracovania a podnetnej diskusii. Zostavovatelia zborníka preto dúfajú, že predkladaný zborník sa stane hodnotným študijným prameňom ako pre vážnejších záujemcov o úniové právo, tak aj súčasťou odporúčanej literatúry na výučbu európskeho práva alebo jeho špecializovaných kurzov na právnických fakultách.
On significance of immunoglobulin class G to glycoprotein E in diagnosis of varicella-zoster virus
Authors: Arsenyeva V. A. , Avdonina A. S. , Mardanly S. S. , Mardanly S. G.
Published: December 2019

Purpose.To evaluate the significance of IgG detection to glycoprotein E of varicella-zoster virus (VZV) for the infection stage diagnosis.

Materials and methods.Integration of literature data.

Results.Analysis of literature data allows to make quite reasonable conclusion that the dynamics of IgG antibodies to glycoprotein E of VZV is subject to the general laws of the antibody productions in the course of infectious processes, although the final completion of this discussion the essential results of direct detection of the dynamics of these antibodies in various stages and forms of the indicated infection.
Features of structural and functional parameters of superficial veins of lower extremities in men with arterial hypertension
Authors: Vagapov T. F. , Baev V. M. , Druzhina L. N. , Letyagina C. V.
Published: December 2019

The aim of the work was to assess the structural and functional parameters of the superficial veins of the lower extremities in men with arterial hypertension. A comparative analysis of the results of the angioscanning of the superficial veins of the lower extremities between 60 men with arterial hypertension and 27 men with normal blood pressure at the age of 30–50 years was performed. In hypertension, an increased rate of venous blood flow and signs of chronic vein diseases are recorded — an increased diameter and area of the lumen of the veins; abnormal venous reflux marked in 10 % of men; in 3 % — varicose veins and thrombotic masses, signs of postrombotic lesion of the superficial veins.

Conclusion. For men with hypertension aged 30–50 years, there is an increased rate of venous blood flow and signs of chronic venous disease of the lower extremities: chronic venous insufficiency, varicose and postrombotic venous disease, which must be considered when stratifying cardiovascular risks and treating hypertension.
Dosing of antibiotics in patients with sepsis, including those undergoing renal replacement therapy
Authors: Shalginskikh A. O. , Yakovlev S. V. , Protsenko D. N. , Sychev I. N. , Suvorova M. P. , Bykov A. O.
Published: December 2019

In critically ill patients the adequacy of starting empirical antimicrobial therapy is a determining factor of the survival of patients with sepsis This article describes the main aspects of the empirical prescription of antibiotics in patients with sepsis who are on renal replacement therapy. Changes in the pharmacokinetic and pharmacodynamic mechanisms that lead to the selection of specific dosing regimens for antibiotics are described. Information on dosing changes for current groups of antibacterial drugs is presented. The purpose of this article is to rationalize antibiotic therapy in a selected group of patients.
On recurrent myocardial infarction and reinfarction
Authors: Gazaryan G. A. , Ermolov A. S.
Published: December 2019

The paper presents three case reports to discuss the criteria of myocardial reinfarction. The cases are of interest because of a short-term interval (from 1 to 14 days) between the infarctions occurred in different coronary arteries. In two cases resulting in a fatal outcome after ineffective PCI, the total affected area of the left ventricle reached 90 %; in one more case, early re-canalizations of two infarct-related arteries at an interval of one day, made it possible to prevent a fatal outcome and preserve the contractile function of the heart. The currently used classification defines such infarctions as primary recurrent infarctions due to the persisting occlusion in one and the same infarct-related artery. In our cases, the infarctions were the results of occlusions in different coronary arteries, and therefore, the total affected area, in case of no effective PCI, covered almost the entire left ventricle, which resulted in a fatal outcome. Such infarctions, despite their early development, should reasonably be defined as reinfarctions rather than as recurrent myocardial infarctions.
Analysis of the use of a selective modulator of cosmulation of T‑lymphocytes abatacept in the treatment of rheumatoid arthritis: data from international clinical practice
Authors: Borisova M. A. , Lukina G. V.
Published: December 2019

This article presents the results of international studies of abatacept efficacy and safety and searching for possible predictors of a good response to the therapy with this drug in real clinical practice.
Improving efficiency of orthopedic treatment of partial teeth loss in inflammatory pathology of periodont
Authors: Amkhadova M. A. , Garazha S. N. , Rakhaeva D. Yu. , Grishilova E. N. , Khubaev Z. S.-S. , Khachaturov S. S. , Nekrasova E. F. , Muzaeva Z. R.
Published: December 2019

The effectiveness of complex orthopedic treatment of partial loss of teeth in inflammatory periodontal disease is a very serious problem. Of particular importance is the choice of materials for removable dentures, as it can contribute to the adsorption of periodontal pathogens. This paper studied the tolerance of dental alloys (cobalt alloy ‘Gialloy PA Co/Cr’, gold-based ‘CASDEN-B’ cobalt alloy ‘Gialloy PA Co/Cr’ with zircon gold plated ‘Kamadan’) to parodontoceras microflora (Staphylococcus aureus, Escherichia coli, Streptococcus pyogenes, Pseudomonasa eroginosa, Candida albicans). It is established that all the studied samples of dental alloys are subject to colonization by periodontal microorganisms in the oral cavity, while the degree of colonization depends on the chemical composition of the alloys and the type of bacterial cultures. Cobalt-chromium alloy with gold-zirconium coating, which is recommended as a structural material in periodontal pathology, has the lowest tolerance indicators of dental structural alloys to periodontal microflora. Based on the analysis of clinical studies, we have established a high efficiency of the use of prostheses made of cobalt-chromium alloy with gold-zirconium coating in the treatment of chronic generalized periodontitis of moderate severity against the background of tooth loss in comparison with the traditional alloy.
Modern ultrasound assessment of elastic properties of the thoracic aorta in patients with coronary atherosclerosis
Authors: Mushkambarov I. N. , Beresten N. F. , Tkachenko S. B. , Romanov S. N. , Kolesnikov V. N.
Published: December 2019

The main goal of echocardiography is not to diagnose CAD or changes associated with CAD, but to reveal non-coronary heart disease. Currently, the development of ultrasound technologies makes it possible to expand the standard echocardiography by evaluating the elastic properties of the thoracic aorta. Due to the fact that studies show correlation between the presence and severity of coronary atherosclerosis with changes in the elastic properties of the thoracic aorta, this solution improves the usefulness of echocardiography in patients with CAD. The most promising in assessing the elastic properties of the thoracic aorta during the traditional transthoracic echocardiography are tissue doppler imaging (TDI) and color M-mode. Color M-mode is a technology that is mainly used in echocardiography to assess the compliance of the left ventricle by examining the mitral inflow propagation velocity. This technology may be used in the descending part of the thoracic aorta, where it will similarly display the elastic properties.
Iron deficiency syndromes in clinical oncology and their correction with nutritive action drugs
Authors: Kostyuchenko L. N. , Mikhailyantz G. S. , Danilov M. Y. , Atroshchenko A. O. , Kruglov A. D. , Noskova K. K. , Lychkova A. E. , Kostyuchenko M. V.
Published: December 2019

Treatment of iron deficiency conditions by nutritive support media is one of the debatable areas. In the analysis of nutritional status, nutritional risk and ferrumdeficiency parameters in patients with operated colorectal cancer in different stages, the possibility of correction of prelatent and latent iron deficiency with ferrum‑containing media of nutritional alimentation is shown. With the development of anemia, the use of с intravenous correction (preferably with drugs sorbed on a special matrix that allows the gland to be isolated in portions) is shown.
Metabiotics: prospects, challenges and opportunities
Authors: Shenderov B. A. , Tkachenko E. I. , Zakharchenko M. M. , Sinitsa A. V.
Published: December 2019

In this review authors discuss modern condition of treatment and prophylaxis of human metabolic diseases associated with microecological imbalance of intestinal symbiotic microbiota. Now the most frequently for these aims various probiotic nutrient additives and functional fermented foods prepared on the basis of living bacteria have been used. Unfortunately such probiotics have not possessed the real effectiveness and are not completely safe. Instead of traditional commercially available living probiotics the authors suggest to use novel microecological means (metabiotics) that are structural components of probiotic bactrerial strains, and/or their metabolites and/or signaling molecules with known chemical structure. Metabiotics can optimize host‑specific physiological, regulator, metabolic and/or hormone/behavior functions and reactions. Metabiotics possess some advantages in future personalized medicine because they have exact chemical structure, well dosed, safe and long shelf‑life.
Clinical efficacy of Meteospasmyl in treatment of painful abdominal and dyspeptic syndromes in patients with chronic pancreatitis
Authors: Grinevich V. B. , Kravchuk Yu. A. , Ped’ V. I. , Rodionov G. G. , Shantyr’ I. I. , Kuvakin V. I. , Svetkina E. V. , Arapkhanovа M. M. , Medvedko S. A.
Published: December 2019

The presented study is devoted to one of the urgent problems of the conservative treatment of chronic pancreatitis — relief of painful abdominal and dyspeptic syndromes. Polymorphism of the etiopathogenetic variants of the formation of pancreatic diseases naturally justifies the need for complex therapy, including secretolytics, antispasmodics medications and polyenzyme drugs. The use of Meteospasmyl in complex therapy effectively relieves abdominal pain and dyspepsia, modifies the composition of the intestinal microbiota and improves the quality of life in patients with chronic pancreatitis.
Treatment of premenstrual dysphoric disorders with combined oral contraceptives
Authors: Loginova K. B. , Dyukova G. M. , Dobrokhotova Yu. V. , Danilov A. B.
Published: December 2019

Premenstrual dysphoric disorder (PMDD) is a severe form of premenstrual syndrome (PMS) with severe psycho-emotional disorders. The frequency of occurrence of PMDD in women of the reproductive period of the Russian Federation is estimated at an average of 15.6 %. The development of PMDD is based on the individual sensitivity of neurotransmitters and neuropeptides to fluctuations in the levels of sex steroid hormones of the ovulatory menstrual cycle, therefore, hormone therapy drugs are used for PMDD therapy — combined oral contraceptives (COC) that suppress ovulation.

The purposeof this study was to evaluate the effectiveness of COC containing drospirenone in the treatment of PMDD.

Materials and methods.78 women of the reproductive period underwent a comprehensive examination and treatment of PMDD symptoms with contraceptives containing 30 mg of ethinyl estradiol and 3 mg of drospirenone (Midian).

Results of the study.The age of patients with PMDD averaged 33.7 years; 55 % of women were between 25–34 years old; 97 % needed contraception; all women represented in the group had higher education, normal menstrual function and body mass index. After 3 months of treatment, there was a statistically significant decrease in pain of various localization, problems with appetite, difficulties in communicating with others, sleep disturbances, and an increase in productivity at work, at home and in school. After 6 months of treatment, COC psycho-emotional symptoms, such as depression, anger, irritation, emotional lability, anxiety, tension, loss of control, significantly regressed, while the effectiveness of therapy reached 50 % relative to the original background. Physical symptoms of PMS, such as swelling of the mammary glands, pain of various locations, sleep disturbances, were stopped on average by 70 %.

Conclusions.COC containing drospirenone can be used to treat severe premenstrual syndrome, i. e. PMDD.
Evaluation of effectiveness of termination of pregnancy in later stages of combined method with congenital malformations of fetus, incompatible with life
Authors: Kravchenko E. N. , Kolombet E. V. , Kuklina L. V.
Published: December 2019

Objective: to evaluate the effectiveness of termination of pregnancy in the later stages of a combined method for congenital malformations of the fetus, incompatible with life. The prospective study involved 195 pregnant women, divided into two groups. The main group consisted of 98 women who underwent termination of pregnancy in the later periods by the following combined method. The comparison group included 97 women, abortion was carried out according to the WHO scheme. The effectiveness of the combined method of termination in late pregnancy in the main group was 99.0 % and 96.9 % in the comparison group.
Risk and possibilities of preventing cardiovascular diseases in women in peri- and postmenopause
Authors: Kuznetsova I. V.
Published: December 2019

Cardiovascular morbidity remains the leading cause of death in the world, in both men and women. But the programs for the prevention of cardiovascular diseases (CVD), which significantly reduced the incidence of cardiovascular complications among men, proved to be ineffective among the female population. Differences in CVD risk factors in different sexes, different responses of the female and male organism to the same treatment effects induce, on the one hand, the development of gender-oriented cardiological practices and, on the other hand, determine the need to include gynecologists in the development and implementation of cardiovascular reduction measures vascular morbidity and mortality.
Postoperative cognitive dysfunction: progress mechanisms and clinical characteristics
Authors: Manysheva K. B. , Akhmedov M. A. , Rakhmanova A. A. , Khutalieva S. M.
Published: December 2019

The article is devoted to the study of postoperative cognitive dysfunction — a syndrome that is often found in the postoperative period and does not depend on the volume of surgeon. Based on the analysis of the results of modern studies, the authors cite the most likely etiological causes of the syndrome, grouped according to different categories of risk factors. The pathogenetic algorithm for cognitive dysfunction includes the appearance of systemic inflammation, improving blood-brain barrier permeability with the endothelial dysfunction, the migration of inflammatory agents into the central nervous system, and the formation of oxidative stress. The clinical manifestations of cognitive deficit in the outcome of surgeon performed under general anesthesia, the authors illustrate with their own observations of patients with a neurosurgical profile with spinal pathology operated on with the use of propofol anesthesia, comparing the results of neuropsychological testing with an assessment of the level of anxiety. In conclusion, the authors outline a strategy for the prevention of postoperative cognitive dysfunction and recommend conducting neuropsychological rehabilitation as an important component of postoperative recovery for all patients with a diagnosed cognitive deficit that occurred after surgery.
Clinical efficacy of complex therapy in patients with chronic pancreatitis and atherosclerosis using ursodeoxycholic acid and high doses of substitute therapy with pancreatic enzymes
Authors: Sirchak E. S. , Opalenyk S. M.
Published: December 2019

The results are presented and the efficacy of prescribing ursodeoxycholic acid and high doses of replacement therapy with pancreatic enzymes for clinical and laboratory indicators in patients with chronic pancreatitis and atherosclerosis is analyzed. The positive effect of the drug UDCA at a dose of 15 mg/kg of body weight for 3 months and high doses of substitution therapy with Pangrol 25 000, 2 capsules 3 times per day for symptoms of diseases, lipid profile,13C-amylase and13C-mixed triglyceride breathing tests in these patients.
40th anniversary of latex allergy and prospects for its overcoming in Russian healthcare
Authors: Volkova O. I.
Published: December 2019

The prevalence of latex allergy among representatives of the Russian medical community is estimated lower (1.9 – 3.8 %) than in the world as a whole (9.7 %), although the incidence of skin, respiratory and other symptoms after contact with latex gloves varies in the range from 18.8 to 35 %. Accurate assessment of differentiated reactions in mediators is hindered by the very rare reference of Russian researchers to the topic of latex allergy. Its prevention is not among the priorities of practical public health, as evidenced by the lack of professional pathology of the skin and upper respiratory tract pathways of latex genesis in the list of occupational diseases, as well as the low level of quality requirements for personal protective equipment for doctors when choosing and purchasing medical gloves. It justifies the need to introduce into practice a number of measures for the prevention and management of latex allergy among health workers: identifying risk groups, verifying diagnosis, providing recommendations on safety management, studying differentiated needs and searching for possible options to meet them.
Application of artificial neural networks to detect bone remodeling changes in diabetes mellitus
Authors: Safarova S. S.
Published: December 2019

This paper describes the task of authentication of bone turnover indicators using the developed method of building a decision support system based on an artificial neural network. A method has been developed for the calculation of risk determinants, which helps the physician in early diagnosis to make an informed decision, based on the identification of changes in bone turnover that increased risk of fragility fractures in diabetes mellitus.
Difficulties in differential diagnosis of atypical forms of dermatofibroma and melanoma (clinical case)
Authors: Vertieva E. Yu. , Saribekyan E. K. , Olisova O. Yu. , Berestok T. S.
Published: December 2019

Dermatofibroma is a benign, often occurring, mesenchymal tumor with extremely low malignant potential. In rare cases, the transformation of this formation into a dermatofibrosarcoma is possible. Dermatofibroma is characterized by a wide range of clinical manifestations due to the abundance of morphological options. Typical variants of diagnostic difficulties usually do not cause. However, atypical forms of dermatofibroma can clinically and dermatoscopically mimic another aggressive tumor, melanoma.
Kaposi’s sarcoma: clinical picture and treatment methods (lecture)
Authors: Yakovlev A. B. , Golanova O. A.
Published: December 2019

The article is presented in the format of a lecture. The material presents data on the etiology and pathogenesis of Kaposi’s sarcoma, the clinical picture of dermatosis, and modern methods of therapy.
Anogenital localization of localized scleroderma in older women: complexity of diagnosis and clinical features
Authors: Snarskaya E. S. , Semenchak Yu. A.
Published: December 2019

According to the criteria of the world health organization, the geriatric population is people who have reached the age of 60 years. Biological aging is accompanied by a progressive decrease in the functional and reserve capabilities of all structural elements of the skin, is a complex process and the result of the influence of both non-modifiable (chronological aging, ethnicity and natural anatomical changes) and modifiable factors (hypoestrogenation, exposure to ultraviolet rays, stress, etc.) Dermatoses occurring with the defeat of the anogenital region in the geriatric group of patients are a big problem not only for diagnosis and treatment, but also significantly worsen the quality of life of patients. Extensive lesions of the anogenital zone are one of the characteristic clinical signs of limited scleroderma, in particular one of its clinical variants — scleroatrophic lichen. (Lichen sclerosisandatroficus). Scleroatrophic lichen (SL) is a chronic autoimmune dermatosis, occurring with a predominant lesion of anogenital tissues, in 85–93 % of cases in women and men.
Chronic spontaneous urticaria: news about problem and treatment (literature review)
Authors: Kruglova L. S.
Published: December 2019

Despite advances in understanding the mechanisms of development of chronic urticaria, in a large percentage of cases there are unsatisfied treatment results, there is no possibility of controlling the disease. Currently, the treatment of patients with chronic urticaria is of a staged nature. In 2014, omalizumab was registered in Russia for extended indications, which makes it possible to achieve control of the refractory form of chronic spontaneous urticaria. The article presents data on the effectiveness and safety of omalizumab. According to the results of numerous studies, omalizumab showed a quick and pronounced effect in the treatment of patients with chronic spontaneous urticaria who do not respond to therapy with H1-receptor blockers. The issues of effective dose, safety and tolerability of the therapy, timing of evaluating the effectiveness, duration of the course and tactics of managing patients with a partial response or lack of response were considered.
Certolizumab pegol for treatment of severe plaque psoriasis: local experience
Authors: Rudneva N. S. , Sadunashvili T. G. , Chumakova Ya. Yu. , Natarova E. V.
Published: December 2019

The article represents the results of a prospective analysis of 28 patients with severe plaque psoriasis and advanced psoriatic arthritis with insufficient response to previous systemic therapy, treated with certolizumab pegol at the Tula Regional Clinical Dermatovenerologic Dispensary in years 2017–2019. Certolizumab pegol demonstrated high and sustained efficacy in improving skin disease and manifestations of psoriatic arthritis. Safety profile of certolizumab pegol was consistent with the therapeutic class.
Features of choice of drugs for external therapy of scleroatrophic lichen of vulva
Authors: Ignatovsky A. V.
Published: December 2019

The article discusses the peculiarities of the choice of the means of external therapy etiology of lichen sclerosus of the vulva based on recent data on vsini of the skin microflora on the course of dermatitis. The efficacy and safety of the cream containing a combination of mometasone, gentamicin, econazole and dexpanthenol are shown.
Diverticular disease of colon. Unresolved issues
Authors: Orlova N. V. , Lukanin D. V.
Published: December 2019

Diverticular disease of the colon is one of the common diseases of the intestine, which is caused by the formation of bag-shaped diverticula in the wall of the colon. The article discusses the clinic, diagnosis, treatment of various clinical forms of diverticular disease. A review of clinical trials of the efficacy of the nonabsorbable antibiotic Rifaximin-alpha is presented. The concept of a microbiome and its functions is given. The article substantiates the appointment of dietary fiber for diverticular disease.
Clinical case of progressive vascular leukophalopathia
Authors: Fedulaev Yu. N. , Kaminer D. D. , Chuprakova A. Yu. , Fatullaev S. T. , Dmitriev B. D.
Published: December 2019

Binswanger’s disease is a rare one. Its cause is vascular damage to the brain. The article discusses the clinic, diagnosis, treatment of Binswanger’s disease on the example of a clinical case.
Current management approaches to patients with atrial fibrillation and percutaneous coronary intervention
Authors: Barbarash O. L. , Kashtalap V. V.
Published: December 2019

In this review are provided relevant positions of the American and European clinical guidelines for antithrombotic therapy in the patients with a combination of atrial fibrillation and coronary heart disease with percutaneous coronary intervention. Similarities and distinctions of positions of two expert communities were discussed. In addition, the evidence-based positions concerning the choice of the optimal antithrombotic therapy are noted. Primary positions of a clopidogrel when choosing the antiagregants for double or triple antithrombotic therapy were designated.