bluuebunny/crossref_metadata_2025 huggingface dataset:
Determination of the active ingredient amounts of expired albendazole drugs
Authors: Atasoy Nurhayat , Aydin Funda , Akpolat Fatma , Yucel Ufuk
Published: July 2024

In this study, it was aimed to determine the active ingredient amounts of 24 expired and 3 unexpired antiparasitic drugs containing the active ingredient albendazole using UV-Vis and RP-HPLC techniques. The drugs were prepared using methanol (MeOH) and 1 N HCl (70:30, v/v) mixture. The quantitative analyses of albendazole were carried out at 338 nm in the range of 1.562-75 µg mL-1 (R2=0.9997) in UV-Vis. In RP-HPLC, separations were achieved using Nucleosil 100-5, C18 column (250 x 4.6 mm, 5µm) in isocratic elution. 0.02 M phosphate buﬀer (pH 3.0) and MeOH mobile phase (30:70, v/v) were used at a flow rate of 1.0 mL min-1. Detections were conducted in the same concentration range (R2=0.9998) using a PDA detector (210 nm). The results obtained using both techniques were evaluated by taking into account the studies in the literature. In this study, it was determined that the loss of active ingredient in veterinary drugs containing different albendazole active ingredient examined decreased over time and that some drugs containing albendazole active ingredient on the market may have less active ingredient amount than the acceptable limit values.
Thiamine-responsive neurological disorder of swine
Authors: Hough Sara , Jennings Samuel , Almond Glen
Published: July 2024

This report describes a thiamine-responsive neurological disease and the methodology leading to its diagnosis. The initial case involved one nursery farm. Approximately 5% of pigs at 5 to 7 days after weaning exhibited central nervous system signs. Over the next 3 weeks, 16 of the company’s 41 nursery farms had pigs with similar clinical signs. One month later, neurologic signs were observed in unweaned piglets in several sow farms. Pigs were weaned at approximately 19 days and moved to off-site nurseries. Live pigs and fresh and formalin-fixed samples from acutely affected pigs were sent to diagnostic laboratories. Feed samples were submitted for mycotoxin and nutrient analyses. Initial reports revealed no precise cause of the neurological condition; however, polioencephalomalacia (PEM) subsequently was identified in affected pigs. A field trial determined the response to treatment with atropine, a vitamin A, D, and E preparation, or vitamin B12 plus thiamine. Pigs treated with thiamine recovered from the neurological condition. Upon implementation of thiamine injections on a company-wide basis, neurological signs associated with PEM were no longer evident. The authors do not recommend routine thiamine injections under normal circumstances. In this case, compromised dietary thiamine levels during feed manufacturing possibly contributed to the PEM.
Effect of fenbendazole on shedding and embryonation of Ascaris suum eggs from naturally infected sows
Authors: Pittman Jeremy , Myers Gil , Stalder Kenneth , Karriker Locke
Published: July 2024

Objectives: To determine reduction of Ascaris suum egg shedding and ovicidal effects in naturally infected commercial female breeding swine treated with fenbendazole. Materials and methods: Five shedding and three embryonation experiments across three commercial sow farms were conducted. Ascaris suum-infected sows were allocated to four treatments: untreated controls; 545.5 mg fenbendazole, 1 day (Treatment 1); 545.5 mg fenbendazole, 3 consecutive days (1636.5 mg total) (Treatment 2); and 1636.5 mg fenbendazole, 1 day (Treatment 3). Fecal samples were collected and evaluated by a standard flotation method (shedding study) or eggs were isolated and incubated (embryonation study) to determine embryonation rates. Groups were compared for time-to-negative (Kaplan-Meier survival analysis); percent negative (chi-square analysis); environmental burden (analysis of variance); and embryonation rates (analysis of variance). Results: Time-to-negative ranges were 9.3-13.1, 8.9-13.1, and 9.8 days post treatment (DPT) for treatments 1, 2, and 3, respectively; control ranges were 13.4-28.2 DPT. Treatment sows were 90%-100% negative, compared to 0.0%-28.6% of controls. Environmental burden ranges were 7.0%-60.9%, 13.9%-60.8%, and 29.3% (treatments 1, 2, and 3, respectively) and 60.4%-219.0% for controls. All treatment values differed from controls (P < .05), but not from each other. Embryonation rates were lower for treatments than controls at 6 and 8 DPT (P < .001). Implications: Fenbendazole at various dosages is effective against A suum infections in sows. Treatment should begin 14 days prior to movement into clean farrowing facilities. Under the conditions of this study, fenbendazole demonstrates ovicidal activity against A suum at 4-8 DPT.
Influence of age at weaning and feeding regimes on the postnatal morphology of the porcine small intestine
Authors: Al Masri Salah , Hunigen Hana , Al Aiyan Ahmad , Rieger Juliane , Zentek Jurgen , Richardson Ken , Plendl Johanna
Published: July 2024

The small intestinal mucosal epithelium is the interface between ingested nutrients and their distribution networks in the underlying vasculature and lymphatics. This review reports on the small intestinal mucosal surface changes in the piglet from birth to the time of natural weaning (> 54 days). Despite numerous publications on the morphological characteristics of the gastrointestinal tract, there is limited comparability among these due to substantial methodological differences. The comparability of the methodological designs used in this review was achieved by relativizing the data to the day of weaning. Weaning at 35 days or later had little to no effect on the intestinal mucosa. Early weaning at 28, 21, 14, 5, 3, and 1 day after birth was associated with dramatic structural changes in the mucosa. A frequent observation after early weaning was prominent villus atrophy. While the crypt epithelium responds to redress these dramatic changes, villus recovery to near preweaning status may be slow. The earlier a piglet is weaned, the greater the villus atrophy and the longer the time to recovery. A causal relationship between reduced feed intake in the first days after weaning, independent of the diet, and the morphological alterations of the intestine is apparent.
THE ATTITUDE OF SECURITY GUARDS TOWARDS DISABLED INDIVIDUALS IN THE MEDITERRANEAN REGION OF TURKEY: A CROSS-SECTIONAL STUDY
Authors: Uskun Ersin , Yıldırım Uz Ayşe , Develi Mustafa , Bozvelioğlu İsmail , Önal Özgür , Kişioğlu Ahmet Nesimi
Published: July 2024

Negative social attitudes towards disabled people make it very difficult for disabled people to integrate into society and the acceptance and integration of disabled people into society continues to be limited to negative attitudes encountered outside the home. The aim of this study is to determine security guards' attitudes towards people with disabilities in Turkey. Data were collected from 469 security guards working in the private or public sector using a questionnaire including the Attitudes Towards Persons with Disabilities Inventory (APDI). The mean (standard deviation) of the APDI is 180.3 (19.1). Positive attitudes are held by more than 98.0% of the research group, both overall and by subcomponents. Security guards with higher levels of education and income had significantly more positive attitudes towards people with disabilities than the others. Acquaintance with a disabled individual is a significant predictor for the competency-independent living subscale (B:2.3, p=0.008). In conclusion, presenting people with disabilities in a realistic way, with their competencies and limitations, is key to developing positive attitudes. In addition, employing individuals with a high level of education in security jobs with appropriate wages can be useful in strategies to develop positive attitudes towards people with disabilities.
SAVUNMA HARCAMALARI VE CARİ AÇIK İLİŞKİSİ: TÜRKİYE ÖRNEĞİ
Authors: Akman Ahmet Mehdi , Aydın Oğuzhan , Zeren Feyyaz
Published: July 2024

Gelişmiş ve gelişmekte olan ulusların güvenliklerine yönelik tehditlere karşı en önemli gerekliliklerden biri olarak karşımıza çıkan savunma harcamaları yine ulusların kendi aralarındaki rekabette de önemli bir harcama kalemi olarak karşımıza çıkmaktadır. Bununla birlikte yapılan bu harcamaların ekonomiye etkileri de yadsınamaz bir gerçektir ve bu da gelişmiş ve gelişmekte olan birçok ulusun önemli bir diğer sorunu olan cari açık kavramı ile bizi muhatap etmektedir. Bu çalışmada da Türkiye’deki savunma harcamaları ve cari açık ilişkisi incelenerek 2006-2023 yılları arasında çeyrek dönemler halinde veriler kullanılarak ampirik analizler yapılmıştır. Fourier Toda-Yamamoto nedensellik testinin uygulandığı çalışmada, savunma harcamalarından cari açığa doğru tek yönlü nedensellik ilişkisi olduğu ortaya çıkmıştır. Bir başka deyişle Türkiye’de yapılan Savunma Harcamaları referans alınan dönemler arasında cari açığı tetiklemiştir. Nedensellik testinden sonra Fourier ARDL Eş Bütünleşme testine geçilmiş, bunun sonucunda ise belirsizliğin söz konusu olduğu görülmüştür.
The Effect Of Job Description On Employee Performance At The Office Of The Regional Revenue Agency Of Tual City
Authors: Ahmad Faqih Zulfikar  , Sri Andayaningsih  , H. A.Muhiddin Daweng
Published: July 2024

This study aims to determine the effect of Job Description on employee performance at the Tual City Regional Revenue Agency Office. The types of data used in this study are primary data and secondary data. The research instrument used in this study used the Likert scale method. Based on the results of data research using statistical calculations through the Statistical for the Social Science (SPSS) application regarding the Effect of Job Description on Employee Performance, the author can conclude that Variable X, namely Job Description, has a positive and significant effect on Employee Performance with a Job Description (X) coefficient value of 0.393 and a calculated t value of 2,836 t > table 2.021 with a significant value of 0.007 < 0.05.
Depth In Providing Banking Credit In Support Improving Village Creative Industries In Langkat District
Authors: Meigia Nidya Sari  , Junawan Junawan , Annisa Fajariah Damanik
Published: July 2024

The national development carried out so far is a development effort sustainability in order to create a just and prosperous society based on Pancasila and the 1945 Constitution. In order to achieve this goal, implementation development must always pay attention to harmony, harmony and balance various elements of development, including in the banking sector. This research aims to deepen the provision of banking credit to support industrial improvement creative village in Langkat Regency. The population used in this research is employees at PT. BRI (Persero) in Langkat Regency. Sampling technique with using saturated samples. The sample size was 30 people. Types of data in this research are primary and secondary data. Data collection techniques use questionnaires, interviews, and documentation studies with data analysis techniques using approaches quantitative with statistical tools of multiple linear regression analysis. The research results show: 1) Internal control has a partially insignificant effect on effectiveness granting credit, 2) Internal audit has a partially significant effect on effectiveness granting credit, 3) Internal control and internal audit have a significant effect simultaneously on the effectiveness of providing credit, namely 83.3%.
Enhancing Corporate Performance Through Transformational Leadership in AI-driven ERP Systems
Authors: Zhang Yang , Huang Fei
Published: July 2024

Organisational traits, technological adoption, and transformative leadership in Chinese enterprises are examined in this study using a dataset 2010–2022. The main goal is to understand how transformative leadership affects business performance and how AI-driven ERP systems, organisational scale, and technology adoption culture modulate this relationship. The paper provides a solid framework for understanding these complex linkages using a big dataset using R and SPSS statistical analysis. Revolutionary leadership consistently boosts business. Organisational size mediates and revolutionary leadership may work better in larger organisations. Technology adoption culture highlights an organization's readiness to accept new technology, regulating the relationship. The study also found that AI-driven ERP systems diminish the correlation, suggesting that higher-tech organisations benefit from transformational leadership. This information can help CEOs adjust their technology and company characteristics strategies. Leadership theories benefit from theoretical implications that highlight contextual aspects that affect leadership dynamics. Understanding how organisational culture affects AI-driven revolutionary leadership may also help. Integrating AI and ethical transformative leadership affects sustainability and trust. Finally, the innovative leadership of AI-driven ERP systems in numerous areas and sizes explains it.
Research on the Application of Artificial Intelligence Technology in Enterprise Digital Transformation and Manager Empowerment
Authors: Li Shanshan , Huang Fei
Published: July 2024

Significant technical developments have occurred in the digital era, altering the dynamics of modern businesses and bringing both difficulties and opportunities. The purpose of this study was to thoroughly investigate the relationship between artificial intelligence (AI) and digital transformation, as well as how these factors affect managerial empowerment and organizational performance. Additionally, the study looked at how employee engagement functions as a mediator and how digital readiness modifies these relationships. Using a quantitative method, a structured questionnaire was used to gather data from a sample of 282 companies that were chosen at random. The AMOS software's structural equation modeling (SEM) aided in the investigation of the linkages. The findings demonstrated strong and positive relationships between AI and digital transformation and organizational performance and managerial empowerment, which were mediated and regulated by employee engagement and digital preparedness. By providing a cohesive paradigm, this study gives practical insights for enterprises managing the digital landscape while also advancing theoretical understanding. This study is unique in that it examines the linkages between AI, digital transformation, employee engagement, and digital preparedness in the context of organizational performance and managerial empowerment.
Catherine’s Growth Through the Changes of Dress in Henry James’s Washington Square
Authors: Zhang Ziyue , Wang Qiusheng , Rutledge David , Liu Jian
Published: July 2024

Many of James’ works, as typical Bildungsromans, delve into the psychological and emotional growth of women. Growth can be manifested in many different ways. The change of vestiture is one of them. Dress can show the character’s taste, judgement towards the outside world, and more importantly, a view to an inner world. At the same time, through the change of dress, we can perceive this character’s psychological and emotional growth. So this essay will explore Catherine’s inner growth through the changes in dress from the perspective of Bildungsroman.
Kenneth Rexroth’s Translation of Du Fu Poetry from the Perspective of Functional Equivalence Theory
Authors: Huang Daoyu , Liu Chang
Published: July 2024

Kenneth Rexroth, a well-known American poet and translator, has contributed to Du Fu poetry translation in the Western society. From the perspective of Nida’s functional equivalence theory, this research takes Rexroth’s English translations of Du Fu poems as a case to study the translation strategies adopted by Rexroth. This explores translation strategies of Du Fu poetry from the perspective of functional reciprocity theory, and is supposed to provide references for the English translation of the ancient Chinese poetry in the future. The above examples all reflect the faithfulness and accuracy of the free translation under the theory of functional equivalence, and accurately express the connotation of the original poem. Above all, the translator has adopted literal translation when translating the above verse. in order to achieve the requirement of the theory of functional equivalence, which enabled the target readers to have the same experience as the original readers. This was the most fundamental purpose of using the literal translation here.
Analisis Kurikulum Merdeka Belajar Dalam Memfasilitasi Pembelajaran Abad Ke-21 Pada Siswa Menengah Atas
Authors: Sri Hanipah
Published: July 2024

The independent curriculum is an educational approach that aims to provide independence to students in their learning so that they can optimally develop their potential. In the era of globalization and the rapid development of information technology, 21st-century learning is an urgent need. This research aims to describe the role of the independent learning curriculum in facilitating 21st-century learning in senior high schools. The method used in this research is descriptive-qualitative with a case study design. The research was conducted at SMAN 2, Merekau, South Papua. Data collection techniques used in this research include in-depth interviews, observation, and documentation. The results showed that: 1) the independent learning curriculum for facilitating 21st century learning is good. It is proven that the learning tools of SMAN 2 Merauke have successfully integrated 21st century skills (collaboration, communication, critical thinking, creativity, character, and citizenship) into the learning tools. 2) The role of the principal and teachers: The principal as the person in charge and teachers as the implementers of learning play an important role in the successful implementation of an independent curriculum with 21st century skills.
Association between Trace elements and cognitive function among Elderly Subjects with Osteoporosis: A retrospective study
Authors: Elkerdasy Yasser Ahmed Abdelaziz , Nasrallah Tarek M , Alzokm Saad M
Published: July 2024

Background: Cognitive dysfunction and osteoporosis (OP) are common among elderly subjects. Different mechanisms are reported. However the potential role of trace elements is not well studied.  The current work aimed to estimate the toenail levels of trace elements in older patients with cognitive function with or without osteoporosis.
Methods:  In a retrospective manner, we collected data of people older than 60 years of age. We collected data of 165 subjects, with 1:1:1 distribution for studied groups (i.e., 55 subjects in each group). The first group for normal cognition with no OP; the second for cognitive dysfunction with no OP and the third for cognitive dysfunction with OP.  The cognitive function was determined by the mini-mental state examination (MMSE), while osteoporosis was diagnosed by the measurement of bone mineral density (BMD) with calculation of T-scores.  Toenail samples were collected and prepared to estimate the levels of trace elements. 
Results: Calcium and zinc were significantly reduced in groups (2 and 3) than the normal group (15.44±1.17 and 13.47±1.81 versus 18.93±1.90 µg/g, respectively; and 88.16±6.10 and 84.07±6.56 versus 104.27±4.79 µg/g, respectively). However, there were significant increase of toenail lead, aluminum and copper in the second and third groups than the first group. But, chromium and selenium were reduced in the second and third groups than the first group. The MMSE and T-scores were proportionately correlated with T-score, body mass index, calcium, zinc, chromium and selenium. But, inversely correlated with lead, aluminum and copper. Finally, calcium, zinc lead, age and BMI were the significant predictors of cognitive impairment and OP.
Conclusion: Trace elements are associated with cognitive impairment with or without osteoporosis. Some are protective and others had harmful effects with different mechanism. Thus, monitoring of these trace elements should be considered to avoid further cognitive decline with or without osteoporosis in future.
AVANÇOS NA TERAPIA GÊNICA PARA TRATAMENTO DE DOENÇAS GENÉTICAS HEREDITÁRIAS
Authors: Silva Luiz Silva , Amorim Adriano , Ortiz Carlos Ortiz , Arruda Karine , Cunha Larissa , Fortes Pedro Fortes , Mello Priscila , Sousa Ricardo , Guarabyra Roberto
Published: July 2024

A terapia gênica tem emergido como uma das abordagens mais promissoras para o tratamento de doenças genéticas hereditárias, oferecendo a possibilidade de intervenções curativas que atuam diretamente na correção das mutações subjacentes. Este artigo revisa os avanços mais recentes nesse campo, baseando-se em uma análise detalhada de 25 estudos que exploram uma variedade de técnicas, incluindo edição genética com CRISPR/Cas9, uso de vetores virais como AAVs e lentivírus, e terapias inovadoras baseadas em células CAR-T. Os resultados desses estudos indicam um progresso significativo tanto em modelos pré-clínicos quanto em ensaios clínicos, com melhorias notáveis em doenças como a β-talassemia, distrofia muscular de Duchenne, e retinose pigmentar. Além disso, avanços na engenharia de vetores virais têm aumentado a eficiência da entrega de genes, ao mesmo tempo em que reduzem o risco de imunogenicidade. No entanto, desafios consideráveis permanecem, incluindo a necessidade de maior precisão na edição genética para evitar mutações off-target, e a complexidade de gerenciar as respostas imunológicas dos pacientes. Este artigo discute esses desafios em detalhes, além de destacar as perspectivas futuras da terapia gênica, que incluem o desenvolvimento de novas tecnologias de edição genética, a otimização dos vetores virais, e a expansão das aplicações das células CAR-T para outras doenças. Conclui-se que, embora a terapia gênica esteja em um estágio avançado de desenvolvimento, a sua implementação generalizada na prática clínica dependerá de mais pesquisas para superar as limitações atuais e garantir a segurança e eficácia a longo prazo.
A Sociopsychological Study of Dystopia in Price's Starters
Authors: Munir Rabia , Imtiaz Rakia , Din Umar-Ud-
Published: July 2024

Dystopia and utopia work in parallel in the same sphere. Every Dystopia has a Utopia, and every negativity has traces of positivity. Utopia is an attribute of modern thought and one of the most obvious results. With a contradiction at its core that does not need to be resolved, it was clear early on in its history that it could take on new meanings, serve new purposes, and crystallize into new structures. This study describes the issues raised by the psychological condition of the protagonist in Lissa Price's Starters, which relates her situation to a dystopian world and leads her to Utopia. In contrast, a descendant of satirical Utopia and anti-utopia, dystopia rejects the idea that humans can attain perfection. Taking mainly the shape of a process and refusing the label of an 'impossible dream', Utopia is a program for change and a gradual betterment of the present; in that sense, it operates at different levels, as a means of political, economic, social, moral and pedagogical reorientation. Finally, Utopia has become a strategy of creativity, clearing the path humans can only follow: the path of creation.
Diagnóstico situacional de uma equipe de saúde da família em municípo de tríplice fronteira: relato de experiência
Authors: Dominguez Cristhian Rolando Agüero , Jimenez Matilde Cristobalina Rosado , Costa Pedro Luís Flora da , Soares Nandra Martins , Mombelli Monica Augusta
Published: July 2024

Entende-se por diagnóstico situacional o resultado de um processo de coleta, tratamento e análise dos dados obtidos no local onde se deseja realizar o estudo. Esta ferramenta é fundamental para conhecer os determinantes sociais em saúde, as características da população vinculada à Unidade de Saúde e sua respectiva equipe de Saúde da Família, bem como a organização dos serviços de saúde. O diagnóstico situacional é essencial para identificar problemas e planejar estrategicamente ações de saúde mais focalizadas e efetivas no território selecionado. O objetivo deste estudo foi relatar a experiência acadêmica no contexto da Estratégia de Saúde da Família para o desenvolvimento do diagnóstico situacional de uma equipe de Saúde da Família. Trata-se de um estudo exploratório-descritivo. Os dados foram coletados por meio de visitas in loco, entrevistas com profissionais de saúde, usuários do serviço e registros do sistema e-SUS. Esta atividade permitiu identificar a importância de reconhecer as demandas de saúde individuais e coletivas, as quais devem ser analisadas considerando as especificidades do contexto territorial e comunitário. Assim, as informações obtidas foram fundamentais para organizar os processos de trabalho da equipe e utilizar o diagnóstico situacional no planejamento adequado das ações oferecidas aos usuários, suas famílias e à comunidade. No que tange a contribuição da experiência a formação acadêmica, destaca-se que o contato direto com a realidade da comunidade e a aplicação prática dos conhecimentos teóricos adquiridos permitiram aos discentes compreender de maneira mais profunda as complexidades do sistema de saúde e as necessidades específicas da população atendida.
Levantamento traumático do seio maxilar com stick boner seguido de instalação de implante: relato de caso
Authors: Delmiro Junior Raimundo da Silva , Vale Nayane Esterfany Souza do , Cruz Érica Karolinne Souza , Souza Rafael Reis de
Published: July 2024

A cirurgia de levantamento de seio maxilar visa a corrigir a insuficiência óssea na região posterior da maxila e viabilizar a instalação dos implantes em casos de perda dentária que geram grande reabsorção óssea e pneumatização do seio maxilar. O presente estudo tem por objetivo relatar um caso clínico de levantamento traumático do seio maxilar com stick boner seguido de instalação de implante, demonstrando à eficiência da técnica cirúrgica e eficiência do implante em sua instalação concomitante a elevação do seio. Paciente F.E.S.A., sexo masculino, 59 anos de idade, compareceu a Clínica Odontológica da Faculdade do Amazonas - IAES com queixa principal “falta de dentes na parte de cima”. Na radiografia panorâmica, além da ausência dos elementos, pode-se observar uma pneumatizacão do seio maxilar, sendo então proposto para o paciente o levantamento traumático do seio maxilar com utilização de plasma rico em fibrina (PRF) e stick-bone para auxiliar a cicatrização e conjuntamente a instalação dos implantes em sessão única. Pôde-se concluir que a técnica utilizada é eficaz garantindo bons resultados e favorecendo o processo de reparo tecidual, contribuindo assim na aceleração e na neoformação tecidual e óssea.
Integração do UpToDate na prática clínica: um estudo abrangente
Authors: Silva Anderson Matheus Pereira da , Barcelos Janice Oliveira Fontenele , Branco Sarah Cecília Guimarães Castelo , Fernandes Neto Rildo Cavalcanti , Lima Keylla Raissa de Paula , Neves Monalisa Macedo Aguiar , Oliveira Victoria Hamaoka de , Almeida Maria Elizabeth Lima , Carvalho Giulia Carolina Pretto , Moreira Anadiely , Cordeio Ligia Pinheiro
Published: July 2024

O UpToDate é uma plataforma digital amplamente reconhecida e respeitada que fornece informações médicas baseadas em evidências. A plataforma oferece uma vasta gama de informações, abrangendo diagnósticos, tratamentos, medicamentos, e diretrizes de manejo para uma ampla variedade de condições médicas. Este estudo visa analisar a integração da ferramenta diagnóstica​ na prática clínica, investigando como médicos e outros profissionais de saúde utilizam a plataforma em suas rotinas diárias. Realizou-se uma análise comparativa entre o UpToDate e outras ferramentas de suporte à decisão clínica. Esta análise foi conduzida com base em critérios estabelecidos na literatura, incluindo a qualidade das informações fornecidas, a abrangência dos conteúdos abordados, a facilidade de uso da plataforma e a frequência com que as informações são atualizadas. A qualidade das informações é um critério fundamental, pois a precisão e a confiabilidade dos dados impactam diretamente a eficácia das decisões clínicas tomadas pelos profissionais de saúde. Os resultados indicam que o UpToDate é amplamente utilizado por médicos e outros profissionais de saúde em todo o mundo. A plataforma distingue-se por fornecer informações atualizadas e confiáveis sobre uma vasta gama de condições médicas, incluindo doenças raras e com plataformas complexas.
O uso de uma Tecnologia Digital de Informação e Comunicação na educação básica para compreensão da matemática como linguagem
Authors: Pivaro Gabriela Fasolo , Couto Mariany de Alencar
Published: July 2024

As mudanças no currículo básico trazem consigo novos desafios. Entre eles, a inserção de aulas de tecnologia na educação básica. Considerando este contexto, analisamos como o ensino de matemática pode ser articulado com a aula de tecnologia através do uso do programa Excel. Para isso, realizamos uma entrevista com uma professora da educação básica da rede pública do Estado de São Paulo, que ministra aulas de Matemática, Física e Tecnologia e Inovação, e inseriu o uso de Excel nas suas aulas de Tecnologia, utilizando conceitos da matemática para fazer pontes entre as disciplinas. A entrevista mostrou as dificuldades para implementação das práticas pedagógicas, como a ausência de computadores para todos os estudantes e a falta de interesse de alguns, mas também apresenta resultados positivos, com estudantes afirmando terem novas noções sobre o que são funções matemáticas. Conclui-se que, apesar dos desafios, o uso de tecnologias pode ser benéfico às práticas de ensino e aprendizagem quando há uma intencionalidade direcionada do professor.
Evidencialidade e extensão mirativa em Kadiwéu
Authors: Couto Mariany de Alencar , Lourenço Gustavo Ribeiro
Published: July 2024

Este trabalho realiza um levantamento da literatura sobre evidencialidade e aspectos de extensão mirativa dentro da evidencialidade, com o objetivo de demonstrar que a língua Kadiwéu (da família Guaicuru) possui esse fenômeno gramaticalizado. Neste idioma, o termo one é utilizado como uma marca do sistema evidencial reportado, enquanto o correspondente negativo é aona, aplicado a eventos passados recentes ou distantes, e atone é usado para evidencialidade com extensão mirativa. A análise dessas palavras dentro das categorias de tipo de fonte de informação propostas por Aikhenvald (2004) revelou-se a abordagem mais eficaz, uma vez que essa autora se dedicou extensivamente a essa categoria. Além disso, Aikhenvald foi pioneira ao afirmar que evidencialidade e miratividade podem se conectar através da extensão mirativa. Isso significa que uma palavra pode ser categorizada como evidencial por sua capacidade de transmitir a fonte da informação, ao mesmo tempo em que fornece informações sobre algo desconhecido e inesperado para o ouvinte, um conceito que Aikhenvald (2004) denomina como mente desprevenida. Este estudo é justificado pela importância do estudo da diversidade linguística para as ciências humanas.
Neologismos semânticos em postagens e reportagens envolvendo conteúdo político na internet
Authors: Burgo Vanessa Hagemeyer , Lourenço Gustavo Ribeiro , Couto Mariany Alencar , Ferreira Eduardo , Freitas Mariana dos Santos
Published: July 2024

Este trabalho tem como objetivo descrever e classificar neologismos políticos empregados na internet e analisar os processos semânticos de ressignificação associados a esses termos. A fundamentação teórica se apoia em autores como Alves (2007), Biderman (1978, 2001), Carvalho (2000), Correia e Almeida (2012), e Pilla (2002), entre outros autores. O corpus de análise é composto principalmente por postagens nas redes sociais Facebook, X (anteriormente Twitter) e Instagram, além de textos jornalísticos com caráter político, todos disponíveis em meio digital entre 2018 e 2021. Os resultados revelam que a ressignificação é um recurso linguístico comum e essencial para a comunicação, permitindo a criação de novos significados e nuances para palavras já existentes no léxico. Esse fenômeno não apenas reflete as mudanças nas discussões políticas online, mas também evidencia a adaptabilidade e a evolução contínua da linguagem no ambiente digital. O estudo enfatiza a importância de observar a velocidade com que esses processos se desenvolvem, uma vez que uma notícia ou evento online pode ter repercussões globais em questão de minutos, ampliando significativamente as discussões políticas tanto no Brasil quanto no cenário internacional.
A HISTÓRIA DO CONFORTO AMBIENTAL E EFICIÊNCIA ENERGÉTICA EM EDIFICAÇÕES: FATORES, REGULAMENTAÇÕES, TECNOLOGIA E ALGORITMOS
Authors: Monteiro Suzane Cruz de Aquino , Monteiro Flávia Pessoa , Oliveira Sávia Mara , Reis Carla Taiane dos Santos , Souza Geldiney Wai Wai de , Santos Raimundo Júlio Viana dos
Published: July 2024

Há setores cujo consumo de energia elétrica é empregado majoritariamente na manutenção e conforto térmico e luminoso dos seus prédios, como o setor residencial, público e comercial, onde suas maiores cargas estão nos sistemas de condicionamento de ar, iluminação e aquecimento ambiental e de água. A relevância desse assunto se dá ao impacto ambiental atrelado à construção (cerca de 16% do fornecimento de água e 25% de madeira a nível mundial) e no consumo de energia elétrica na fase de utilização. No Brasil, as edificações compõem 51,0% da energia elétrica consumida, segundo o Balanço Energético Nacional 2023 e a complexidade está no balanceamento ideal entre o conforto ambiental e a eficiência energética. Este artigo visa apresentar uma revisão desta área, como os principais fatores que influenciam no conforto ambiental e eficiência energética em edificações, além de regulamentações, tecnologias e algoritmos de otimização a fim de contribuir na fundamentação de pesquisas nessa área.
Avaliação das condições de saúde mental dos trabalhadores da estratégia saúde da família do município de Campina Grande – PB
Authors: Santos Kauê Kemiac , De Moraes Allana Renally Cavalcante Santos , De Espíndola Cínthia Andrade , Cruz Cristine Diniz Coutinho , Chaves Arélli Pâmella Brasileiro , Santos Eclésio Cavalcante , Lima Monalyza Myllenna Silva Monteiro , Santos Edenilson Cavalcante
Published: July 2024

Mental disorders are considered a serious public health problem, so that, according to the Pan American Health Organization (PAHO), one billion people in the world have some type of mental disorder. Approximately 15% of workers suffer from some type of mental disorder, which is one of the main causes of years lived with disability and absence from work. The objectives of this study were: to investigate the mental health conditions of workers of the Family Health Strategy (FHS) in Campina Grande – PB and to identify the prevalence of Common Mental Disorders (CMD) among workers. This is an observational, descriptive, quantitative, cross-sectional research, carried out with FHS workers from the Medical Residency Program in the Municipality of Campina Grande – PB, between October 2023 and January 2024. The structured tools "Sociodemographic Questionnaire", "Occupational Questionnaire" and "Self Report Questionnaire" (SQR-20) were used. The mean age of the participants was 41.5 ± 11.3 years, most of them Community Health Agents, female, married, with up to two children and per capita income greater than 2 minimum wages. The overall prevalence of CMD was 43.5%, being present in all professional categories, and more frequent among social workers (100%), but without statistical differences. The study identified that professionals have a high prevalence of psychic disorders, especially female professionals.
Meningkatkan Aktivitas dan Hasil Belajar Siswa MAN 3 Kota Banjarmasin Melalui Model Pembelajaran Kooperatif Tipe TPS Pada Materi Diferensial
Authors: Hamdani
Published: July 2024

ABSTRAK
Diferensial fungsi trigonometri merupakan materi yang diajarkan di kelas 12 IPA Madrasah Aliyah Negeri 3 Banjarmasin. Dari hasil ulangan harian siswa kelas 12 IPA 1 MAN 3 Banjarmasin diketahui kemampuan siswa dalam hal ini masih belum memuaskan. Sehingga diperlukan perbaiki agar pembelajaran siswa yang diberikan lebih bermakna. Contextual Teaching and Learning (CTL) atau pendekatan kontekstual adalah kemampuan pembelajaran yang memungkinkan bagi siswa untuk mengaitkan pelajaran di madrasah dengan konteks nyata pada kehidupan sehari-hari sehingga memahami makna yang dipelajari. Penelitian ini bertujuan untuk meningkatkan kemampuan siswa kelas 12 IPA 1 MAN 3 Banjarmasin dalam menyelesaikan diferensial fungsi trigonometri serta untuk mengetahui aktivitas siswa selama proses pembelajaran melalui pendekatan kontekstual dengan model pembelajaran kooperatif tipe TPS.
Metode yang dipakai pada riset ini adalah metode PTK (Penelitian Tindakan Kelas). Subjek pada roset ini adalah siswa kelas XII IPA 1 MAN 3 Banjarmasin sebanyak 38 siswa. Teknik pengumpulan data yang dipakai adalah tes dan observasi serta dokumentasi. Analisis data yang dihasilkan adalah dengan persentase, dan rata-rata hasil belajar.
Hasil riset menyatakan bahwa kemampuan siswa dalam menyelesaikan turunan fungsi trigonometri meningkat, yaitu adanya peningkatan secara klasikal persentase ketuntasan siswa dan dilihat dari nilai mean bahwa hasil belajar siswa meningkat dari siklus 1 ke 2. Melalui pendekatan kontekstual, model pembelajaran kooperatif tipe TPS, terjadi peningkatan aktivitas siswa pada pembelajaran matematika.
Kata kunci: Meningkatkan, Aktivitas, Diferensial, Kooperatif, TPS
Resilience as a predictor of suicide risk in volunteers of the Ecuadorian Red Cross
Authors: Gaibor Gonzalez Ismael Alvaro , Vargas Espín Alba del Pilar , Rodríguez Pérez Mayra Lucía , Lara Salazar Cristina Mariela , Gavilanes Gómez Guillermo Daniel
Published: July 2024

Introduction: suicide is a public health problem against which resilience, which is the ability to cope positively with adversity, could act as a protective factor.Objective: to determine whether resilience can predict suicidal risk. Methods: a descriptive, cross-sectional, correlational and predictive study was conducted. A descriptive, cross-sectional, correlational and predictive study was carried out, the Plutchik Suicide Risk Scale and the Wagnild and Young Resilience Scale were applied to a group of 288 Ecuadorian Red Cross volunteers between 18 and 67 years of age, 58,3 % of whom were women, 41,7 % men. Results: a slight negative correlation was found between resilience and suicidal risk and that resilience predicted suicidal risk in this population, in addition most of those evaluated presented a low level of resilience and did not show suicidal risk. Conclusions it is possible that resilience acts as a protective factor against suicidal risk
Methodological research competencies of pre-service teachers
Authors: Rivas-Urrego Gabriela , Urrego Ana Jacqueline , Araque Juan Carlos , Valencia Samir
Published: July 2024

The exercise of teaching requires the development of research processes as an activity inherent to the profession. From this statement, the objective of this research was derived, which was to analyze the methodological competencies in research of teachers in training at two universities in Ecuador. To this end, a study was developed with a quantitative approach, with a non-experimental design and exploratory field research. The sample was intentional with 325 students from two universities in Ecuador, to whom a digital form was shared, attending to the methodological dimensions referred to determination of approaches, designs, scope, sample selection, instrument design, as well as information analysis, among others. The results indicated greater difficulties in defining the appropriate methodological route for the research, connecting the methodological theory to the reality of the study, constructing the instruments according to the research interests, interpreting and/or analyzing the results obtained and relating the results to the existing theory. It is concluded that the student's willingness to develop metacognitive processes that self-regulate their learning and the dedication of the teacher is required for the search for strategies that allow the achievement of the objectives in the subjects of the epistemology and research methodology field
Emerging Strategies in Thyroid Cancer Immunotherapy: A Comprehensive Systematic Review and Meta-Analysis of Clinical Outcomes
Authors: Estrella Cornejo Daniel Alejandro , Carriel Alvarado Meylin Yalitza , Chávez Villagómez Norma Susana , Díaz Parra Alberto Dario , Navas Espinosa María Fernanda
Published: July 2024

Introduction: the most prevalent endocrine cancer is thyroid cancer (TC), which has a low death rate despite a rising frequency. In order to assess the clinical results of novel immunotherapeutic approaches in TC, this systematic review and meta-analysis will concentrate on treatment-related adverse events (AEs), overall response rate (ORR), progression-free survival (PFS), and overall survival (OS). Methods: a thorough search was done on PubMed, Embase, and ClinicalTrials.gov, covering research published between January 2018 and December 2023. The inclusion criteria were satisfied by 14 research, including a range of TC subtypes and study methodologies.Results: the effectiveness of immunotherapy varied throughout TC subtypes. In advanced TC with PD-L1 positivity, pembrolizumab showed a 9 % ORR and a 7-month PFS. In advanced/metastatic TC, camrelizumab + famitinib demonstrated ORRs of 33,3 %-62,5 % and 8,4-month PFS. Patients who tested positive for PD-L1 had greater responses to spartalizumab (19 % ORR) in ATC. Combination treatments, such as pembrolizumab and lenvatinib, demonstrated encouraging outcomes in ATC and poorly differentiated thyroid cancer (PDTC), with 34,3 % ORRs and a significant increase in PFS. With the fixed-effects model, the pooled ORR was 40,8 % (95 % CI, 37,2 %-44,5 %), and with the random-effects model, it was 33,4 % (95 % CI, 20,8 %-48,9 %). Considerable heterogeneity (I2 = 94,4 %, p < 0,01) demonstrated varying treatment outcomes across several immunotherapy protocols. Conclusion: immunotherapy has promise in the treatment of advanced tuberculosis, especially aggressive forms such as ATC, especially when used in combination regimens. Subsequent investigations have to concentrate on refining combination tactics and finding biomarkers for patient selection
Beyond Boundaries Uniting Internal Medicine and Surgery in Patient Care - A Narrative Synthesis
Authors: Vera Alay Danny Manuel , Costales Vallejo Luis Ricardo , Bernal Cevallos Valeria Lizbeth , Jiménez Aleman Viviana Nataly , Medina Herrera Gary Adolfo , Astudillo Pinos Daniel Ismael , Delgado Medina Luz María , Sarango Coronel Maryuri Guicella
Published: July 2024

Introduction: the evolving landscape of healthcare necessitates the integration of internal medicine and surgery to address complex patient needs comprehensively. Traditional boundaries between these disciplines are increasingly blurred, prompting a holistic approach to patient care.Objective: this narrative review aims to synthesize current literature on the integration of internal medicine and surgery, exploring collaborative models, integrated care pathways, technological advancements, and interdisciplinary initiatives to enhance patient outcomes.Method: a comprehensive literature search was conducted across PubMed, Scopus, Web of Science, and Google Scholar using keywords and MeSH terms related to internal medicine, surgery, interdisciplinary collaboration, and patient outcomes. Inclusion criteria included 30 articles discussing integrated care models and their impact on patient outcomes, published in English between 2009 and 2024. Data extraction focused on study characteristics, key findings, and outcomes. Results: the review identified several collaborative frameworks, such as multidisciplinary teams and perioperative surgical homes, which improved diagnostic accuracy, treatment efficacy, and patient satisfaction. Integrated care pathways demonstrated effectiveness in managing chronic diseases and complex surgical cases. Technological advancements, including EHRs and telemedicine, facilitated seamless communication and data sharing. Challenges to integration included institutional silos, cultural differences, and time constraints, but these were mitigated through interdisciplinary training and policy incentives.Conclusions: integrating internal medicine and surgery enhances patient care by leveraging the combined expertise of both fields. Overcoming barriers through technological innovations, education, and policy changes is crucial. Future research should focus on long-term outcomes, patient engagement, and the role of personalized medicine in integrated care
Technological innovations in cardiac rehabilitation: effectiveness and impact on patient's quality of life
Authors: Ivanovska Olha , Tyravska Oksana , Shtepa Olha , Meleha Kseniia , Fedorenko Tetiana
Published: July 2024

Introduction: today, the issue of effective rehabilitation of patients after ischemic damage to the heart muscle is relevant in connection with the annual increase in the number of patients with chronic cardiovascular pathology. Objective: to establish modern effective methods of cardiorehabilitation through a literature search. Methods: a review of the literature on the topic of innovations in cardiorehabilitation using databases: GoogleScholar, PubMed, Web of Science, Scopus was carried out using the survey and system analysis method. These methods provide the possibility of remote monitoring of patients with chronic cardiovascular diseases using telemonitoring, which encourages patients to monitor the state of the cardiovascular system based on ECG, blood pressure, and oximetry. Telecardiorehabilitation is a modern method that has been widely implemented in the last 10 years, and especially during the outbreak of the COVID-19 pandemic. Taking into account that after discharge from the hospital, elderly people sometimes find it difficult to get to rehabilitation centers or work in groups. Development:  as an alternative, specialists found the possibility of physical rehabilitation with a set of exercises at home and constant monitoring with the help of smart technologies. The introduction of modern techniques increased the percentage of patients who were involved in cardiorehabilitation, which reduced mortality rates and positively affected the quality of life of patients. Conclusions: the implementation of telemonitoring and telecardiorehabilitation in the conditions of aging population and increasing share of patients with chronic course is a very promising direction of modern rehabilitation
Hasta ve hasta yakınlarının erkek hemşireye ilişkin görüşleri: sistematik derleme
Authors: Şahin İsa , Baykal Ülkü
Published: July 2024

Bu çalışma erkek hemşirelerle ilgili yapılan çalışmaların değerlendirilerek hasta ve hasta yakınlarının erkek hemşirelere ilişkin görüşlerini ortaya koymak amacıyla yapılmıştır. Çalışmalara ulaşabilmek için Google Scholar, Web of Science, Pubmed, YÖK Tez Tarama ve Türk Tıp Dizini veri tabanları kullanılmıştır. Veri tabanlarında “erkek hemşire”, “hasta” “hasta yakını” ve “Türkiye” gibi anahtar sözcükler ile İngilizce ve Türkçe dillerinde taranmıştır. Veri tabanlarında yapılan taramalar sonucunda 90 ulusal yayına ulaşılmıştır. Araştırmaya dahil edilme kriterlerine uygun olan 15 yayın çalışma kapsamında değerlendirilmiştir. Tüm yayınlar çalışma yöntemleri ve bulguları açısından incelenmiştir. Türkiye’de erkek hemşireleri inceleyen çalışmaların çoğunlukla 2012-2018 yılllarında, tanımlayıcı araştırma olarak yapıldığı saptanmıştır. Hasta ve hasta yakınlarının, hemşirelik mesleğini her iki cinsiyetinde yapabileceği konusunda farkındalığı bulunmaktadır. Çalışma, Türkiye’deki erkek hemşirelere ilişkin yapılan çalışmaların çok fazla olmadığını ve erkek hemşirelerle ilgili daha fazla çalışmanın yapılmasına gereksinim duyulduğunu ortaya koymuştur. Ayrıca erkek hemşirelere ilişkin yaklaşımlarını belirlemeye yönelik herhangi bir ölçek çalışmasının olmadığı saptanmıştır.