bluuebunny/crossref_metadata_2025 huggingface dataset:
Surface water contamination with Acanthamoeba spp. in Ilam city, Iran
Authors: Ghadesi Azadeh , Hasanpour Hamid , Naserifar Razi , Abdi Jahangir , Mahmoudi Mohammad Reza , Turki Habibollah , Raiesi Omid , Getso Muhammad Ibrahim , Mirzaei Asad
Published: April 2024

Acanthamoeba, a widely distributed free-living amoeba with 20 genotypes identified through rRNA gene sequencing, exhibits varying degrees of pathogenicity influenced by its genotype. This study focuses on assessing the prevalence of Acanthamoeba species in the surface waters of Ilam, located in western Iran, utilizing morphological analysis and sequencing of the 18S rRNA gene through the PCR method. A total of 50 water samples were collected from various regions within Ilam city, situated in the southwest of Iran. To isolate Acanthamoeba parasites from the samples, a culture method was used, and all utilized culture media were scrutinized through microscopic and molecular techniques. The parasite's genotype was determined by sequencing a 500-bp fragment of the 18S rRNA gene. Using microscopic and molecular methods, 19 and 16 water samples tested positive, respectively. The 18S rRNA sequences revealed that the isolates belonged to the T4, T2, and T11 genotypes. This study emphasizes the presence and inclination for close contact with highly pathogenic genotypes of Acanthamoeba in the surface waters of Ilam City.
Desponte Apical de Plantas de Zínia Aumenta a Produção e a Qualidade de Hastes Florais
Authors: Suzano Ellen Maria Gomes , Bruner Amanda Paes Leme de Mello , Pêgo Rogério Gomes
Published: April 2024

Zinnia elegans é uma espécie ornamental de múltiplos propósitos de ornamentação. Nos últimos anos o potencial de uso dessas plantas como flor de corte tem sido estudado, no entanto, poucos são os estudos que determinam sua produção em campo. Uma das técnicas utilizadas para obtenção de plantas em campo com maior número de flores é o desponte apical, que tem como objetivo promover a brotação lateral de ramos e aumentar o número de flores produzidas. Por isso, esse trabalho objetivou avaliar os efeitos do desponte apical aplicado na cultura, visando uma produção com maior rendimento e qualidade de hastes florais. As plantas produzidas a partir da germinação de sementes e as mudas foram transplantadas, aos 21 dias após a semeadura, para os canteiros em espaçamento 20x20cm. Aos 15 dias após o transplantio foram realizados o desponte apical que consistiu nos tratamentos, sendo caracterizados como se segue: T0: Controle (sem desponte apical); T1: Desponte mantendo uma gema; e T2: Desponte mantendo 2 gemas. O experimento foi realizado em canteiros, sob condições naturais, a nível de campo. Utilizou-se o delineamento em blocos casualisado, com três tratamentos distribuídos em 4 blocos sendo avaliadas 8 plantas por parcela. Ao final do ciclo de produção foram avaliadas a altura da planta, o peso fresco da planta, o número de folhas, o número de inflorescências, o comprimento das hastes florais, o diâmetro das inflorescências e o ciclo da cultura. Com base nos resultados, pode-se concluir que é recomendável realizar a poda de zínia mantendo 2 gemas para aumento da produtividade e qualidade de hastes florais.
Vegetação e Legislação Ambiental: Estudo de Regularização de Passivos Ambientais Aplicado no Município de Ipiranga de Goiás – Goiás - Brasil
Authors: Césaro Silvana Gino Fernandes de , Leal Antonio Cezar , Dutra e Silva Sandro
Published: April 2024

A floresta primária que compunha a região do Mato Grosso de Goiás, e no qual atualmente está localizado em uma dessas áreas o município de Ipiranga de Goiás/GO, experimentou a partir da década de 1940, por meio da política da “Marcha para o Oeste”, uma supressão vegetal significativa desse ecossistema único. As áreas florestadas das Matas de São Patrício, porção norte do Mato Grosso de Goiás, sofreram forte impacto a partir das políticas que favoreciam a ocupação das florestas por meio de incentivo à regularização fundiária, mas sobretudo a partir da criação da Colônia Nacional Agrícola de Goiás (CANG). Atualmente, o remanescente florestal encontra-se dentro do território do bioma Cerrado, mapeamento criado a partir de 2004 e que orienta as políticas ambientais brasileiras. Assim, esse estudo reflete sobre a situação dessa região, tendo como base a legislação vigente, mas também apontando para os elementos históricos. A falta da vegetação obrigatória em Área de Preservação Permanente (APP) e de Reserva Legal (RL) é um fator que impacta negativamente a prestação de Serviços Ecossistêmicos (SE) e por isso a legislação brasileira exige que sejam recompostas. A Lei 12.651/2012 criou o Cadastro Ambiental Rural (CAR), determinando que todos os responsáveis por imóveis rurais com passivos ambientais devem promover a recomposição da vegetação legalmente protegida e que está suprimida. Os prazos para estas adequações estão vigentes em todo o país e considerando que no município de estudo a vegetação nativa está limitada a fragmentos pelo uso do solo em desconformidade com a lei, se faz necessária a recomposição destes passivos. Este artigo apresenta uma proposta sistematizada para a conexão de fragmentos de vegetação, considerando os elementos ecológicos característicos de remanescente florestal no Cerrado, com a recomposição da vegetação no município de Ipiranga de Goiás/GO, com a indicação da criação de Corredores Ecológicos nas APPs hídricas.
Serviços Ecossistêmicos e a Potencialidade da Flora do Cerrado
Authors: Vargem Daiana da Silva , Braz Vivian da Silva , Lemes Erick de Oliveira , Peixoto Josana de Castro
Published: April 2024

Os serviços ecossistêmicos (SE), ou serviços ambientais, são considerados os bens e serviços que obtemos dos ecossistemas de forma direta ou indiretamente, sendo essenciais para o bem-estar humano. Isso se faz útil para avaliar a relação entre homem e natureza, e também sobre sua capacidade de conservação dos recursos naturais. Dentre os benefícios oferecidos pelos SE estão os serviços culturais, de suporte, de regulação e de provisão, destacando-se para estes últimos, os recursos medicinais fornecidos pela flora. O objetivo deste estudo foi realizar uma abordagem teórica sobre a conceituação e classificação dos SE, evidenciando a potencialidade da flora do Cerrado na provisão destes serviços. A metodologia utilizada neste estudo foi uma revisão bibliográfica sistemática da produção quantitativa e qualitativa do tema nos últimos vinte anos.
Evaluación de dos complejos enzimáticos en dietas de postura sobre la reproducción de la Codorniz Japonesa
Authors: Cumpa G. Marcial , Chia G. Liu
Published: April 2024

Un experimento fue llevado a cabo con el objetivo de evaluar el efecto de la adición de dos complejos enzimáticos a dietas de  codornices reproductoras. 135 codornices japonesas (90 hembras y 45 machos) fueron asignadas durante 56 días en 3 tratamientos: T-1 (Control), T-2 (con adición de celulasa y proteasa) y T-3 (con adición de amilasa, xilanasa y proteasa). Los resultados del experimento no mostraron diferencias significativas entre tratamientos en producción de huevos, masa de huevo, peso de huevo, consumo de alimento, conversión alimenticia,  fertilidad, incubabilidad, natalidad y peso de codorniz BB. Al análisis de la  retribución económica del alimento se determinó que  la mayor eficiencia la obtuvo el tratamiento 1, sin suplementación de enzimas.
Evaluación del diámetro, longitud y rendimiento al lavado de la fibra de Vicuña en el Patronato del Parque de las Leyendas
Authors: Trejo C. Wilder , Baquerizo R. Maite , Palacios P. Gloria
Published: April 2024

El presente trabajo se ha llevado a cabo con 35 animales, 19 machos y 16 hembras, pertenecientes al Patronato del Parque de las Leyendas en Lima - Perú.  El objetivo ha sido determinar el diámetro de fibra, longitud de fibra y rendimiento al lavado de tres zonas corporales del animal (paleta, costillar y grupa). El promedio general del diámetro de fibra fue de 11.23 ± 2.25 µ; con un coeficiente de variabilidad de 20.02%. El diámetro correspondiente a las tres zonas estudiadas han reportado valores de 11.15 ± 2.25 µ para la zona de paleta, 11.25 ± 2.25 µ para la zona de costillar medio y un valor de 11.31 ± 2.22 µ para la zona de grupa, el vellón de la vicuña es homogénea pues no presenta diferencias significativas; lo cual impide encontrar una zona representativa para el muestreo del diámetro; en cuanto a la diferencia de sexo, se ha encontrado que las hembras tienen un diámetro promedio de 11.35 ± 2.32 µ, mientras que los machos tienen 11.10 ± 3.32µ. También se realizó la curva de distribución de frecuencia la cual nos indica que el 81.73% de la fibra se encuentra por debajo del promedio (11.23 µ). Para el caso de la longitud de fibra el promedio encontrado ha sido de 0.94±0.54 pulg., con un coeficiente de variabilidad de 62.12%. Para el promedio por de 62.12%. Para el promedio por zonas  registró que la zona del costillar medio es la más larga con una longitud de 1.02 ± 0.56 pulgadas seguida de la zona de grupa con 0.97 ± 0.56 pulgadas y la zona de menor largo es la zona de paleta con 0.82 ± 0.45 pulg. La curva de distribución de frecuencia nos indica que el 58.47% de la fibra se encuentra por debajo de 0.94 pulgadas. En cuanto a la longitud para los sexos hay una alta diferencia significativa (P<0.01) entre las hembras con 1.19 ± 0.63 pulg., y los machos con 0.70 ± 0.44 pulg. El rendimiento al lavado nos reporta un rendimiento de 72.67%. Para el rendimiento de acuerdo al sexo se tiene que las hembras tienen un rendimiento de 77.46% y los machos 67.88% con alta diferencia significativa (P<0.01).  Palabras
Seroprevalencia de Neospora caninum en una población ganadera lechera de la Cuenca de Lima
Authors: Gamarra C. Segundo , Salazar R. Ivonne , Zarate R. Daniel , Vargas M. Jorge
Published: April 2024

La neosporosis es una parasitosis que afecta el rendimiento económico con pérdidas importantes para la industria pecuaria al ocasionar abortos y mortalidad neonatal. El objetivo del presente estudio fue determinar la seroprevalencia de la infección por Neospora caninum en bovinos de una granja lechera, ubicada en el distrito de La Molina, departamento de Lima, en el año 2005. Se evaluaron 56 muestras de suero sanguíneo, recolectadas de vacas Holstein, mediante la prueba de inmunofluorescencia indirecta (IFI). El 69.64 % de los animales presentaron anticuerpos contra el parásito. Se encontró evidencia de transmisión vertical y horizontal; la edad no representó un factor de riesgo, pero existe la predisposición de que el animal adquiera la enfermedad conforme avanza la edad. Estos resultados corroboran la presencia de N. caninum en bovinos lecheros de la cuenca de Lima.
Problema de Valor Inicial para un Sistema Dispersivo No Lineal de Ondas Largas Regularizado
Authors: Mendoza U. Aldo
Published: April 2024

En este trabajo de investigación, estudiaremos el sistema de ecuaciones no lineales dispersivas bajo el efecto de disipación, es un número entero. Nuestro objetivo es demostrar que el sistema dispersivo o problema de Cauchy, esta bien formulado localmente y globalmente. Por esta razón vemos varias propiedades de las soluciones reales.
Análisis de Productividad y Costos en la Fabricación de Pisos de Shihuahuaco (Dipteryx spp.)
Authors: Vidal M. Mariana , Chuquicaja S. Carlos , Meléndez C. Miguel
Published: April 2024

Se analiza el rendimiento y productividad, así como se determina la estructura de costos del proceso de transformación de la madera Dipteryx spp. de tablones a tablillas de piso deck en una empresa maderera de la ciudad de Pucallpa. El rendimiento de la materia prima se halla en base a una muestra de 106 tablones; el estudio de tiempos así como el análisis y cálculo de costos se realizan en base a una orden de trabajo por 20 m3 de pisos. Se encontró un rendimiento de tablón a producto de 29,12%, con un desperdicio del 58.81% luego de recuperar el 11.07% del volumen inicial de los tablones. Se determinó que para la producción de un contenedor de 20 m3 de decks considerando un turno diario, se requieren 30 días laborables: 13 turnos de trabajo y 17 días adicionales para el secado de la madera. El costo de un metro cúbico de piso tipo deck en madera shihuahuaco es de US$ 762; en caso no asignar los costos fijos dicho costo disminuye a US$ 699.
Nulidad del Acto Jurídico
Authors: Ardiles R. Grecia
Published: April 2024

El presente trabajo de investigación fue realizado aplicando la escuela metodológica del Sincretismo de Carnelutti, el cual consiste en la ubicación histórica del tema (Nulidad del Acto Jurídico) y su evolución. Así como punto importante del planteamiento de ésta escuela metodológica, es la búsqueda del dato, la cual nosotros la hemos ubicado en la voluntad, puesto que, la voluntad es lo que direcciona el sentido de nuestros actos y desemboca por consiguiente en consecuencias jurídicas. El objeto de la presente investigación es poder establecer el avance conceptual de la nulidad del acto jurídico, puesto que, a la fecha un acto se reputa como nulo, porque encuentra un defecto en su estructura. Asimismo como principal conclusión podemos resaltar que la Legislación Civil Peruana vigente, trata como sinónimos a los términos nulidad e invalidez, teniendo cada uno de éstos definiciones distintas, dado que, la invalidez constituye el género y la nulidad una especie, por lo que, es errada la asignación de nulidad como sinónimo de invalidez en la normativa civil peruana, conllevando por lo cual a una confusión en el sistema jurídico.
Lo absurdo y lo fantástico en los cuentos de Julio Ramón Ribeyro
Authors: Vega M. Nehemías
Published: April 2024

La narrativa fantástica de Julio Ramón Ribeyro está integrada por un grupo pequeño de cuentos, quizás por ello ha sido poco estudiada por la crítica literaria peruana y extranjera que ha preferido analizar sus cuentos realistas. La mayoría de los estudios sobre la narrativa fantástica de Ribeyro comete errores al considerar algunos cuentos absurdos como fantásticos. El presente trabajo mostrará la diferencia entre lo fantástico y lo absurdo para así evitar la confusión entre ambas modalidades que Ribeyro trabaja en su narrativa corta. Para ello, analizaremos los cuentos “La insignia”, “Silvio en El Rosedal”, “Doblaje” y “Ridder y el pisapapeles”.
Evaluación del pardeamiento enzimático durante el almacenamiento en congelación del puré de Palta (Persea americana Mill) Var. Hass.
Authors: Hernández M. Ernesto , Briceño B. Luis
Published: April 2024

Con la finalidad de prolongar su tiempo de conservación, pulpa refinada de palta variedad Hass fue tratada con antioxidantes ( mezcla de ácido cítrico y ácido ascórbico) y envasada al vacío y sin vacío, luego de lo cual fue almacenada en congelación (-18 ºC) durante 150 días. Al inicio y durante el almacenamiento se determinó la actividad enzimática de la polifenoloxidasa (PFO) y se evaluó el color de la pulpa en base al sistema de coordenadas de cromaticidad L, a y b. Durante el almacenamiento se evaluó también el pH y las características sensoriales. Se encontraron altas reducciones de actividad de la PFO cuando el ácido cítrico y el ácido ascórbico fueron adicionados como aditivos. El puré con alta disminución de la actividad de la PFO fue menos sensible al cambio de color, el que se manifestó por la pérdida de la luminosidad original y el verdor de la pulpa. Los aditivos utilizados fueron los factores que más evitaron las reacciones de pardeamiento.
Recent Advances in Catalytic Systems for the Reduction of Aromatic and Aliphatic Nitrile Compounds to Amines
Authors: Ansari Sara , Shariati Shahab
Published: April 2024

Amines are important and valuable compounds widely used in the chemical industry
to produce various products such as dyes, detergents, solvents, additives, pharmaceutical products,
and anti-foam agents. A property that distinguishes primary amines from other compounds
is their straightforward functionalization. Therefore, the synthesis of different amine compounds
has been considered by many researchers in recent years. Usually, primary amines are produced via amination of alcohols, reductive amination, and reduction of nitro and amide compounds. Furthermore, a useful and atom-economical method for producing primary amines
is reducing nitrile compounds using catalytic systems. Traditionally, nitriles are reduced using
metal hydrides such as LiAlH4 or NaBH4. These methods have important restrictions in terms
of selectivity and waste generation. Hence, the heterogeneous and homogeneous catalysts were
investigated for the hydrogenation of nitriles to diverse amines. This review describes the performance
of different catalytic systems for reducing nitrile compounds to their corresponding
amines.
Structural Perspectives in the Development of Novel EGFR Inhibitors for
the Treatment of NSCLC
Authors: Makhija Rahul , Sharma Anushka , Dubey Rahul , Asati Vivek
Published: April 2024

Non-small cell Lung cancer (NSCLC) is the most common type of lung cancer, which is
caused by high consumption of tobacco and smoking. It is an epithelial lung cancer that affects
about 2.2 million people across the globe, according to International Agency for Research on Cancer
(IARC). Non-small cell lung cancer is a malignant tumor caused by EGFR mutation that occurs
in the in-frame deletion of exon 19 and L858R point mutation in exon 21. Presently, clinically
available inhibitors of EGFR (including erlotinib, lapatinib, gefitinib, selumetinib, etc.) are not specific
and responsible for undesirable adverse effects. Moreover, to solve this problem search for
newer EGFR inhibitors is the utmost need for the treatment and/or management of increasing lung
cancer burden. The discovery of therapeutic agents that inhibit the specific target in tumorous cells,
such as EGFR, is one of the successful strategies in treating many cancer therapies, including lung
cancer. The exhaustive literature survey (2018-2023) has shown the importance of medicinally privileged
pyrimidine derivatives together, fused and/or clubbed with other heterocyclic rings to design
and develop novel EGFR inhibitors. Pyrimidine derivatives substituted with phenylamine, indole,
pyrrole, piperazine, pyrazole, thiophene, pyridine and quinazoline derivatives substituted with phenylamine,
pyrimidine, morpholine, pyrrole, dioxane, acrylamide, indole, pyridine, furan, pyrimidine,
pyrazole etc. are privileged heterocyclic rings shown promising activity by inhibiting EGFR and
TKIs. The present review summarizes the structure-activity relationship (SAR) and enzyme inhibitory
activity, including IC50 values, percentage inhibition, and kinetic studies of potential compounds
from various literature. The review also includes various aspects of molecular docking studies
with compounds under clinical trials and patents filed on pyrimidine-based EGFR inhibitors in
treating non-small cell lung cancer. The present review may benefit the medicinal chemist for developing
novel compounds such as EGFR inhibitors.
Heteroaromatization of Coumarin Part II: Synthesis, Reactions, and Antimicrobial Activities of Novel Pyrido[2,3-d]pyrimidine Derivatives
Authors: Borik Rita M. A. , Abd El-Wahab Ashraf H. F. , Mohamed Hany M. , Ismail Khatib S.
Published: April 2024

Background:

Condensation of 3-acetyl coumarin (1) with 2‐(4-methoxy- benzylidene)
malononitrile (2) in ammonium acetate/acetic acid or absolute ethanol/piperidine affords
pyridine (3) and chromen-2-one (4) derivatives, respectively.

Methods:

In this study, the reaction of 3 with an electrophilic reagent, namely, formic acid,
acetic anhydride and formamide afforded the pyridopyrimidinone and pyridine derivatives (6-
9). Also, treatment of 3 with different aromatic aldehydes, carbon disulfide, NaN3/NH4Cl, 2-
(4-methoxybenzylidene)malononitrile and acetophenone afforded pyridopyrimidinone, carbamodithioic
acid, tetrazol-5-yl-chromen-2-one, 2H-chromen-2-one, and pyridine derivatives
(10-14), respectively.

Results:

This study synthesized coumarins with antimicrobial activity and verified the structure
and purity of the synthesized compounds using spectral data.

Conclusion:

The new compounds were evaluated in vitro for their antimicrobial activity
against gram-positive bacteria (Staphylococcus aureus, Methicillin-resistant Staphylococcus
aureus) and gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa), in addition
to fungus (Candida albicans). The investigated substances 3 and 14 presented good activity
against MRSA, E. coli, P. aeruginosa and C. albicans, while compounds 9, 10a-c, 11, 12 and
13 exhibited good to moderate activity.
Filtration of Natural Derivatives as MAO Inhibitors by Virtual Screening: A Potential Lead for Neurodegenerative Disorders
Authors: Malik Neelam , Agnihotri Supriya , Dhiman Priyanka
Published: April 2024

Aim:

The purpose of the current study was to explore the virtual library for the
screening against Monoamine oxidase (MAO) isoforms. An in-house library of natural based
ligands was docked within the active sites of MAO isoforms and their in vitro study was also
conducted.

Objective:

The prime objective of the current study was to screen and validate the natural-based
derivatives for MAO inhibitory action with the least adverse effects and get molecular aspects
about further structural modifications on the most active leads.

Background:

The importance of MAOs in controlling the activity of the central nervous system
has been extensively studied. Our goal in this work is to identify a prospective natural lead molecule
that has a stronger affinity for the MAO enzyme in order to produce a more effective natural
candidate for a neurological agent.

Methods and Results:

In order to get insight into how different categories of natural compounds
interact with the targeted protein, we virtually screened the numerous natural compound categories
in the current study. Rhamnetin, quercetin, piperine, eugenol, and umbelliferone showed the
highest dock scores in the case of MAO-B, with scores of -10.57, -9.938, -9.445, and 7.821, respectively.
For MAO-A, umbelliferone, curcumin, caffeic acid, and quercetin, the corresponding
dock scores were -8.001, -7.941, -7.357, and -6.658. Additionally, an in vitro MAO inhibitory
experiment was utilized to assess the top-ranked compounds with the best docking scores.
The most potent Human Monoamine oxidase (hMAO-A) inhibitor, with an IC50 of 10.98±0.006
M and a selectivity index (SI) of 0.607, was discovered to be the compound umbelliferone.
Rhamnetin, the lead chemical, has demonstrated hMAO-B activity with a value of 10.32±0.044
M (SI value of 3.096).

Conclusion:

These natural potential ligands have been found remarkable to the standard compounds
against MAO-A and MAO-B, and they could be used as a lead chemical in the development
of novel therapeutic candidates. The in silico screening results and in vitro hMAO inhibitory
efficacy exhibited strong correlations.
Micropropagation Studies on Genus Cissus A Review
Authors: Joshi Ridhi , Saini Parmila , Singh Nathawat Raghunandan , Patni Vidya
Published: April 2024

The genus Cissus Linn. belongs to the Family Vitaceae (formerly
Ampelidaceae) and comprises about 350 species distributed all over the world, having
rich phytochemicals with medicinal as well as commercial value. This genus is a
storehouse of large varieties of phytochemicals such as alkaloids, flavonoids, and
phytosterols, making this genus pharmaceutically important. Some species contain high
quantity of calcium ions in their stem extract, which is possibly responsible for their
bone healing activity. In vitro propagation of plantlets provides the opportunity to
conserve endangered species as well as to use the beneficial species without disturbing
their natural habitat. The present review comprises in vitro protocols used to conserve
the species, exploit and enhance useful metabolites. The whole plant, parts and
metabolites isolated from in vitro cultures of Cissus species may be used further for
pharmaceutical purposes.
Micropropagation Protocol in Atropa acuminata Royle ex Lindl. and Atropa belladonna L.
Authors: Manjula S. , Manjula B. L.
Published: April 2024

Atropa, a Solanaceae member, contains many active chemical compounds
such as atropine, saponins, polyphenols, scopolamine and hyoscyamine. Because of the
presence of these active principles, endangered species Atropa acuminata and Atropa
belladonna have been indiscriminately exploited in traditional medicine for treating
various disorders and thus Atropa acuminata has become an endangered species in
some regions. Due to the threat of extinction, low seed germination and seedling
survival rate, there is a need for conservation through efficient micropropagation
protocols. In this regard, the current chapter is focused on micropropagation
methods/protocols developed by various researchers using various explants of Atropa
acuminata and Atropa belladonna and their responses to different media compositions
with respect to direct and indirect organogenesis in vitro, as the technique of in vitro
regeneration has played a pivotal role in the mass multiplication of many plant species.
Micropropagation of the Medicinal Plant 'Sarpagandha' [Rauvolfia serpentina (L.) Benth. ex Kurz] and its Applications in Human Welfare
Authors: Mukherjee Suproteem , Biswas Diptesh , Ghosh Biswajit
Published: April 2024

Rauvolfia serpentina (L). Benth. ex Kurz., commonly known as
Sarpagandha (Indian snakewood), of the family Apocynaceae, is a medicinally
important woody shrub. Since ancient times, the root of this shrub has been used for
treating numerous diseases, especially hypertension, mental agitation and
cardiovascular diseases. In addition to eighty different alkaloids, all well-known for
their pharmaceutical properties, the plant also contains reserpine, recognized as the
world's first antihypertensive drug. Thus, the demand for this plant has only grown in
the pharmaceutical industry. However, overexploitation and abysmal traditional
propagation methods have endangered this valuable species' natural vegetation,
creating an unpleasant gap between the demand and availability. In this scenario, the in
vitro micropropagation technique comes as an alternative strategy to help replenish this
threatened shrub's natural vegetation loss and commercial needs. Furthermore, the
beneficial features of the plant tissue culture technique by providing genetically
uniformed disease-free true-to-type plant propagation within a short time, and
conserving elite variety plantlets makes this technique an inevitable tool for the rapid
production of economically important plants in the 21st century. Therefore, this chapter
focuses on the different in vitro plant tissue culture techniques applied to regenerate R.
serpentina plants. In addition, the roles of various physical and chemical factors that
could affect the regeneration rate, geographical distribution, bioactive compounds and
their bioactivity have also been discussed. The comprehensive data could be helpful for
further studies on this valuable plant.
Micropropagation of Wrightia Species
Authors: Asha S.
Published: April 2024

The genus Wrightia belongs to the Apocyanaceae family and encompasses
32 species. This genus has many pharmacological properties and is used for many of
the human ailments in the traditional systems of medicine. It also has commercial
importance for its timber, dye, etc. Due to its commercial importance, some of the
species of this genus, like Wrightia tinctoria and W. arborea are overexploited and
have become endangered. There is a need to conserve these species. One of the
techniques to conserve plants and multiplication is micropropagation. In this chapter,
regeneration studies that include collection, sterilization, shoot and root generation, and
acclimatization of Wrightia tinctoria and W. arborea are described.
In vitro Regeneration and Conservation of the Medicinal and Aromatic genus Kaempferia: An Overview
Authors: Chakraborty Avijit , Ghosh Biswajit
Published: April 2024

Genus Kaempferia comprises about 124 species distributed in Southeast
Asia and is well known for it's diverse medicinal, nutritional and industrial values. The
plants of the genus are rhizomatous, perennial, and oil-yielding plants; some are also
used as spices. The essential oil obtained from the plants has a considerable market
value worldwide. The rhizomes of these plants were used in traditional medicine due to
the presence of diverse bioactive compounds and used to treat urinary tract infections,
fever, cough, hypertension, metabolic disorder, asthma, rheumatism, epilepsy, skin
diseases, etc. Seed dormancy, seasonal outgrowth and seed made through crosspollination were found to be non-viable, which are the prime limitations of ex situ
conservation regarding this genus. To overcome this type of problem, in vitro tissue
culture is the way to get the plants available over the year without any limitations. This
chapter is based mainly on exploring those bioactive compounds containing species of
the genus Kaempferia, and obtaining an alternative resource of phyto-compounds for
use in pharmaceuticals and conserving them through an artificial way to get them
throughout the year without exploiting the area and genotypic alteration.
Clarification of the precedence relationship between “Gujiga” and “Haega” Viewed as a narrative backdrop
Authors:   Korean Language & Literature, Byeon Sook-ja , Hyeon Seung-hwan
Published: April 2024

This study starts from the question of the sequential relationship between the two songs, based on the relationship between “Gujiga” and “Haega” shown in the tale of King Suro of Gaya in “Garakgukgi” and Lady Suro of Silla in “Surobuinjo” recorded in “Samgukyusa”. To state the conclusion in advance, I would like to reveal that “Haega” is more ancient than “Gujiga”. It is said that “Haega” was sung during the reign of King Seongdeok of Silla, so the temporal distance from“Gujiga” to “Haega” is a whopping 700 years. The main focus is to understand what changes have occurred in the process of transmission of the two songs. The foundation is found in the methodology of historical folklore. The purpose is to find meaning by comparing the changes in folklore 700 years ago and 700 years later. In this article, we attempted to explain the sequential relationship between “Gujiga” and “Haega” based on folkloristic evidence related to the historical change process of the “Gimhae” region, which is the regional background of “Garakgukgi”, and the ancient marriage ritual and Ritual for wishing for a child. Based on the findings of the research, it can be asserted that “Haega”, originating from the belief in the marine realm, predates “Gujiga” which amalgamates beliefs in the sea and the subsequent celestial domain.
A Study on the Language of Haenyeo in Wando-gun, Jeollanam-do
Authors:   Korean Language & Literature, Kim Gyoung-pyo
Published: April 2024

This study analyzed the language of Haenyeo in Wando-gun lexically, grammatically, and phonologically. In the case of the vocabulary related to the name of the Haenyeo, their work style, and their work tool in Wando-gun, it was similar to the vocabulary used under the influence of the Jeju Haenyeo, but the Jeonnam dialect vocabulary was also used. Regarding the act, Wando’s native Haenyeo used ‘hwipalam, hukkesoli’, and Wando’s settlement Haenyeo used ‘hombes-soli, sonbi-soli, sunbi-soli’, so there was a difference between the two. The particles and connective ending in the language of Haenyeo in Wando-gun coexisted with both Jeonnam dialectal forms and standard language. However, The standard language was used more frequently. Glide was similar to Jeonnam dialect or Jeju dialect. The w-glide formation was coexisting in two forms, but the form in which w-glide formation occurred was more common. The y-glide formation was coexisting in two forms, but the ‘i+eo→yeo’ type is likely to be more common after glide formation. These linguistic characteristics of Wando-gun Haenyeo seem to have been influenced by various factors, including broadcasting media, keeping a distance from local residents, collection methods such as traditional methods and scuba diving, and increased income.
Effect of salinity on Growth and Secondary Metabolites of Sesbania Grandiflora seedlings: An Analytical Study
Authors: Nikam Nisha , Kolla Vara Prasad , Choudhari Yamini , Tiwari Roshni
Published: April 2024

Plants can undergo different types of stresses like biotic and abiotic stresses. Plants develop mechanisms to overcome these threats of biotic and abiotic stresses, which influence secondary metabolite production, enhancing the potential to overproduce useful phytochemicals for varied applications. Salt stress has a major impact on Agriculture. It results in losses of 806.4 billion rupees per year due to low production yield. Salinity affects plants in various aspects including water stress, ion toxicity, nutritional imbalance, oxidative stress, metabolic processes, membrane disorganization, cell division, and genotoxicity. Using in vitro plant cell culture to produce chemicals and pharmaceuticals has made great strides. A soft wooded tree, Sesbania grandiflora has many significant medicinal values that have been proven scientifically. It is known to work as an immune modulator along with the property of nitrogen fixation. A study was conducted to determine the effect of NaCl salinity on growth, morphological analysis, and phytochemical content in Sesbania grandiflora using in vitro method. Seeds of Sesbania grandiflora germinated on 10, 20, and 30mM NaCl salt concentrations for varying durations, and total flavonoid and phenolic content production was calculated to observe the correlation between salt stress and phenolic production. Thus, the salt stress effect and its effect on the phytochemicals were observed. The present study findings provide additional information for the accumulation of phytochemical compounds under salt stress in the plant which might help to explain the increased levels of secondary metabolites in other plant species.
Psychosomatic Disorder
Authors: Dhale Pranita
Published: April 2024

Abstract: The word psychosomatics comes from the Greek word “psyche (mind) and “soma” (body) psychosomatic illness is on illness that affects the mind And body in some case mentl and emotions disorders can increases many studies have shown that chronic diseases . mouth burns etc. Psychosomatic disorder include physical and mental disorders. The physical symptoms of the diseases are caused by mental or emotional problems if often lead to stress , anixiety ,and depression when menatal disorder are not recognized ,physical pain wil occure due to hystriea although oral and paraoral patterns indicate psychosomatic disorders . The term psychosomatic diseases ,oral diseases , stress etc .relevent articles were selected and filtrated from the database using .
Online Fraud Detection System
Authors: Dhanwani Prof. D. C.
Published: April 2024

Abstract: Financial services are used everywhere and function with high complexity. With the increase in online transacting, frauds too are increasing alarmingly. An automated Fraud Detection System is thus required. With millions of transactions taking place, it is practically impossible to detect frauds manually with good speed and accuracy. We propose a system is that provides a robust, cost effective, efficient yet accurate solution to detect frauds in both online payment transactions and credit card payments. The proposed solution is a Machine Learning model that will serve the purpose of detecting “fraudulent” and all the “genuine” transactions in real time. This is beneficial for all sectors that are even mildly aligned to finance. The solution will help them analyse based on various factors if the ongoing transaction can be harmful and will prevent many unfortunate incidents.
Comparison of Bracings and Fluid Viscous Dampers in 15-Storey Buildings across All Seismic Zones of India under Bi-Directional Excitation
Authors: A Akarsh , Shivaraju GD
Published: April 2024

Abstract: An earthquake is a natural phenomenon i:e, sudden horizontal movement of earth’s crust that causes sudden collapse of buildings and other structures such as large monuments, bridges etc. The damage of the building is based on the amount of magnitude and intensity of the earthquake. A building can withstand in lower intensity of earthquake. But higher intensity causes lots of damages on building or a building can suddenly collapse and causes increase in number of deaths. To mitigate these effects a control system is to be provided such as base isolations, dampers, bracings etc. The current topic is based on the behavior of linear and non linear fluid viscous damper provided at center and both side corners of 15 Storey RC building in diagonally bracing system. The building is modeled and analyzed by using ETABS software. Here IS 1983(part1): 2002 and medium soil type are to be considered for analysis with respect to all seismic zones (zone II - zone V) of India. Here linear static and response spectrum analysis are applied in each model. Results are to be drawn based on base shear, storey displacement and storey drift to understand how fluid viscous dampers helps to reduce the effects of earthquake.
Do indirect measures of attitudes improve our predictions of behavior? Evaluating and explaining the predictive validity of GATA
Authors: Chernozub O. L.
Published: April 2024

The generalization of the results accumulated to date has shown that the implicit measures of attitudes (some even suggest defining them with a less pretentious term “indirect”) show a disappointingly weak predictive potential in relation to real behavior. Thus, the predictive validity of the Graphical Association Test of Attitude (GATA), which also claims to be an indirect method, has been questioned. To check this assumption, we analyzed the results obtained with GATA in 64 predictions provided that the predicted outcome could be verified by real action. Such forecasts cover the domains of electoral, consumer and communicative behavior. In some cases, the prediction based on the data from a representative sample was checked referring to the actual behavior of the group represented by the sample, e.g., the electorate, or the consumers of a certain category of goods, etc. In other cases, the accuracy of the forecast was checked for each respondent. This allows to avoid the effect of “mutual compensation” of erroneous forecasts with opposite valence. The test method consisted of a comparison of the prediction accuracy of pairs of “control” and “experimental” prediction models: the only difference identified was that the latter used the data from indirect measurements of GATA as an additional factor of action. In the article, all models are presented in their simplest and most transparent versions. The results of the conducted meta-analysis do not fully correspond to the general trend: the use of the GATA data significantly and continuously improves the accuracy of predicting behavior. In addition, the incremental effect on the accuracy of individual forecasts (for each respondent) turned out to be higher than that of the sample-based group forecasts.
Forms of the higher education participation in ensuring labor productivity
Authors: Toshchenko Zh. T
Published: April 2024

Such a formulation of the question as labor productivity in the context of higher education may seems unusual and controversial, since in most cases this issue is considered in the analysis of economic problems, of the use of such resources in production as the improvement of technology, equipment and management, working conditions and organization. However, this list of means for increasing labor productivity should include an analysis of the preliminary stages at which future specialists begin to develop a set of qualities for productive work - educational process in all its diversity, which receives insufficient attention. The article identifies the forms of participation of Russian universities in solving one of the central tasks in increasing the efficiency of the economy - training future specialists for productive work. As a rule, the concepts ‘productive labor’ and ‘labor productivity’ are used in relation to the real production, as evidenced by numerous studies, technological and economic policies, and actual production activity. The article shows that for the implementation of the national program “Labor Productivity and Employment” the preparatory stage for solving this problem is especially important, which involves a radical reconstruction of the universities’ strategies for training students for future work: career guidance, professional selection, professional practice, and professional adaptation. The author considers these forms of the higher education participation in solving problems of labor productivity and productive labor referring to the research conducted by the Institute of Sociology of the Federal Center of Theoretical and Applied Sociology of the Russian Academy of Sciences and by the Russian State University for the Humanities and to the conclusions and suggestions of scientists, teachers and practitioners who studied, applied and/or summarized the experience of students’ preparation for future professional life.
Innovation bureaucracy in the higher education management
Authors: Barkov S. A , Markeeva A. V , Gavrilenko O. V
Published: April 2024

In recent decades, the Russian education system has been constantly reformed. Its current state and problems cannot be understood without identifying the subject initiating and carrying out these permanent changes. Such a subject is an innovative bureaucracy - a specific type of bureaucracy that serves innovative processes and creates social and organizational routines from them. This bureaucracy managed to make a conveyor of innovations, which often moves in a circle - without beginning or end. The reforms have become pendulum and repeat at certain intervals. The article considers numerous consequences and excesses of the innovative bureaucracy’s dominance in the higher education management, which are determined by this bureaucracy success in replacing the real, socially significant goals of the higher education system with indicators that can be quickly achieved and reported as if for the public good. The harsh administrative pressure of the innovative bureaucracy leads to the constant updating and combination of standards (although not all their content can be standardized), to an increase in reporting (including in electronic, online form) and in teaching load. The lack and ambivalence of goals and the non-stop projects of changes hinder the formation of institutional matrix to meet the contemporary challenges and determine destabilizing processes in the education system. The authors argue that an institutional approach to the higher education management can change the situation, since it focuses not on administrative orders and formal goals but on establishing norms and rules for the education system self-development. Thus, the efficiency of the education system should be evaluated by the society and the state and not by representatives of the innovative bureaucracy, who strive to preserve the innovation conveyor. The principles of post-industrial management should be applied in the higher education system, replacing the bureaucratic approach to the implementation of innovations.
Opening speech at the meeting of the scientific-sectoral section “Sociological Sciences” of the 6th Professorial Forum “ Science and Education as the Basis for the Development of Russia. Personnel for an Innovative Economy”
Authors: Gorshkov M. K
Published: April 2024

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Ideia de “cidade intermediária” à luz do conceito de transação social
Authors: Dimas Cardoso Antônio
Published: April 2024

El artículo aborda el concepto de transacción social a la luz de la idea de “ciudad intermedia”, según el planteamiento del sociólogo belga Jean Remy. Considera el papel de intermediación que desempeñan las ciudades de tamaño mediano en áreas urbanizadas o en proceso de urbanización, dependiendo de sus respectivos contextos nacionales o regionales, particularmente en Brasil. Desde una perspectiva interpretativa, el estatus de “ciudad intermedia” está asociado al concepto de transacción social y, así, puede revelar los vínculos sociales entre los habitantes de la ciudad que interactúan en el espacio urbano. Este trabajo postula que el concepto de Remy contribuye en gran medida a la comprensión de situaciones concretas en los intersticios de las ciudades, siendo las transacciones sociales mediadoras de acciones y relaciones simultáneas de proximidad y distancia, incluso en América Latina.
Beyond Words: Transformations of 'Hamlet'
Authors: Eliana Polvere
Published: April 2024

This paper proposes a reworking of scenes 4 and 5 from William Shakespeare's "Hamlet" through an interdisciplinary approach combining textual analysis and artistic production. The investigation begins with an analysis of key words extracted from the original text, conducted through the use of the AI KOBI platform. The reflections and suggestions that emerged from this phase played a key role in inspiring my creative process. The paper follows the research journey from its initial stage to its development and conclusion. The research culminates in the creation of a series photographic images transforming the concepts explored.
Alcanzar la presión arterial y el colesterol LDL objetivo no previene la progresión de la carga de placa aterosclerótica en una población de alto riesgo
Authors: H A Perez , E Majul , A L Oliszynsky , A Delia , D Bocchetto , C B Albrecht , I M Baez , T I Foa , L M Gonzalez Rinaldi , S A Lambrech , S E Muñoz , M N Carrillo , D J Spence , N H Garcia
Published: April 2024

INTRODUCION: La enfermedad aterosclerótica es una enorme carga para la salud en todo el mundo, y su prevención está basada en gran medida en el control de los factores de riesgo tradicionales, a pesar de la eficacia limitada en la prevención de eventos cardiovascular (ECV). La mejoría en la estratificación del riesgo se puede lograr a través de la detección de progresión del área total de la placa (TPA) medida por ecografía carotidea, la cual ha demostrado duplicación del riesgo basal en estos pacientes en un intervalo de 1 año. Nuestra hipótesis es que el control de la presión arterial y el colesterol LDL sérico en valores objetivo (según guías clínicas actuales) son insuficientes para reducir la progresión de la aterosclerosis en personas sin eventos previos, con alto riesgo cardiovascular. METODOS Y RESULTADOS: Estudio observacional prospectivo de 742 participantes con alto riesgo cardiovascular en un programa de prevención primaria cardiovascular. Se determinaron dos mediciones de ultrasonido de TPA para cada participante durante al menos un año. Incluimos en el análisis 57 participantes que mantuvieron una presión arterial por debajo de 130/80 mmHg y un colesterol sérico de lipoproteínas de baja densidad (LDL-C) por debajo de 100 mg/dl durante todo un año. Los participantes con progresión de la placa de TPA definida como aumento sobre el basal mayor de 5 mm2 se compararon con aquellos con cambios de TPA de 5 mm2 o menos (grupo sin progresión) mediante análisis de regresión logística multivariable. Después de una media de estadía en programa de casi 8 años, con Presión Arterial de 120.4 + 9/68.6 + 8 mmHg y LDL colesterol de 81 + 25 mg/dl, identificamos progresión de TPA en 22 de 57 (39%) participantes. No detectándose diferencias para ninguna covariable al comparar progresión versus no progresión. CONCLUSIÓN: La progresión de TPA ocurre hasta en el 39% de los individuos a pesar de mantener la presión arterial por debajo de 130/80 y el LDL-C sérico por debajo de 100 mg/dl. La evaluación de TPA puede ayudar a resolver las limitaciones de las pautas establecidas para la prevención de eventos de ECV en personas de alto riesgo.