bluuebunny/crossref_metadata_2025 huggingface dataset:
Preparation and Application of Platinum Composite Microelectrode (PCM) for the Routine Analysis of Acetaminophen in Pharmaceutical Products
Authors: Riyanto Riyanto , Safarudin Ahmad
Published: March 2017

Preparation and application of platinum composite microelectrode (PCM) for the routine analysis of acetaminophen in pharmaceutical products has been carried out. This electrode was prepare by Pt powder and PVC in 4 mL tetrahydrofuran (THF) solvent and swirled flatly to homogeneous followed by drying in an oven at 100 °C for 3 h. The mixture was placed in 0.5 cm diameter stainless steel mould and pressed at 10 ton/cm2. The cyclic voltammetry were performed in a three electrodes system using PCM as a working electrode, an Ag/AgCl (saturated KCl) as reference electrode and platinum wire as the counter electrode. Electroanalysis of acetaminophen was performed in 0.1 M H2SO4 as an electrolyte. The result of the study showed that the correlation of determination using PCM electrode for electroanalysis acetaminophen was R2 = 0.999. Precision, recovery, LOD and LOQ of the PCM towards acetaminophen were found to be 1.04%, 100.54%, 19.52 mg/L and 65.08 mg/L, respectively. As a conclusion, the methods can be used for routine analysis of acetaminophen in pharmaceutical product. Simplicity of sample preparation and use of low cost reagents are the additional benefit of this method.
Antiplasmodial Evaluation of One Compound from Calophyllum flavoranulum
Authors: Abbas Jamilah , Syafruddin Syafruddin
Published: March 2017

Calophyllum flavoranulum (Clusiaceae family) is a big tree and medical plants from the tropical rain forest of the Indonesian continent. The organic extracts from stem bark yielded phenyl coumarin. The structure was elucidated with the aid of spectroscopic technique. Antiplasmodial activities of isolated compound was tested in vivo against Plasmodium berghei parasite and showed the best antiplasmodial activity. New flavoranulum coumarin compound showed activity against P. berghei parasite with inhibition growth 0, 31.33, 40, 30.67, 46 and 34% at dosage 1.1x10-10, 1.1x10-9, 1.1x10-8, 1.1x10-7, 1.1x10-6, and 1.1x10-5 mg/mL, respectively. Flavoranulum coumarin very active as antiplasmodial, and at 3 and 4 day incubation all of parasite were died.
Deactivation and Regeneration of Ni/ZA Catalyst in Hydrocracking of Polypropylene
Authors: Khabib Imam , Kadarwati Sri , Wahyuni Sri
Published: March 2017

The phenomena of catalyst deactivation and the effects of regeneration method on the characteristics and activity of Ni/ZA catalyst after being used in a continuous cracking reaction of polypropylene have been studied. Ni/ZA catalyst was prepared using sonochemical method with total metal intake of 4%. Characteristics and activity of fresh, spent, and regenerated catalyst were evaluated to get a better understanding about the catalyst deactivation. Characteristics which have been observed include catalyst acidity, porosity, crystallinity, and surface morphology. Catalytic activity test of Ni/ZA catalyst on polypropylene cracking reaction at temperature of 500 °C with H2 flow rate of 20 mL/min and catalyst:feed ratio of 1:2 (w/w) showed the decrease of some catalyst characteristics such as specific surface area, total pore volume, and acidity due to coke fouling over a five-times continuous experiment. Regeneration of catalyst with oxidation-reduction method has been able to increase the activity and acidity of catalyst up to 7.47% and 38.54%, respectively, compared to those of spent catalyst, while the catalyst surface area and total pore volume decreased up to 32.83% and 26.92%, respectively.
Chemical and Physical Properties of Cassava Starch–CM-Chitosan–Acrylic Acid Gel Copolymerization by Gamma Irradiation
Authors: Rekso Gatot Trimulyadi
Published: March 2017

Starch is a renewable natural polymer that can be decomposed easily in the environment and can be modified to various applications such as biomedical, agricultural and pharmaceutical applications. Copolymerization of gelatinized starch–CM-chitosan and acrylic acid (AAc) in aqueous medium using γ-irradiation was carried out. The preparation conditions, such as irradiation dose and AAc concentration were investigated. The copolymers were characterized by FTIR spectroscopy, thermo-gravimetric analysis (TGA) and scanning electron microscopy (SEM). The results show that by increasing of irradiation dose the gel fraction increases till the dose of 15 kGy. Above the stating dose the gel fraction decreases. The Equilibrium Degree of Swelling (EDS) value slightly increases with increasing irradiation dose and after dose of 15 kGy is decreasing. The swelling of starch–CM-chitosan–AAc hydro gels reduced as the gel content increases. The results indicated that the optimum condition for obtaining hydro gels with desirable properties was irradiated at dose of 15 kGy. The results indicated that SEM revealed that the higher the dose, the lower the copolymer pore size. The starch–CM-chitosan–AAc copolymers have thermal stability higher than that for starch individually.
SECONDARY METABOLITE FROM ENDOPHYTIC FUNGI Chochlibus lunatus OF THE RHIZOME OF TUNJUK LANGIT (Helmynthostachys zaylanica)
Authors: Fitrya Fitrya , Muharni Muharni
Published: March 2017

Helmynthostachys zaylanica which is locally known as tunjuk langit is included Ophioglosaceae genus. The rhizome of tunjuk langit is traditionally used as anticancer. Chochlibolus lunatus was isolated from the tissues of tunjuk langit rhizome. Fungal strain was identified based on the characteristics of its colony and cell morphology. Chochlibolus lunatus was cultured in Potato Dextrose Broth (PDB) medium and it was then extracted using ethylacetate (EtOAc). A secondary metabolite compound was isolated from EtOAc extract. This isolation was done by chromatography technique and the structure of this compound was determined by mean of UV, IR and NMR spectroscopic technique. Isolated compound is like oil. Based on spectra analyses, we concluded that this isolated compound was 11,12,13-trimethylheksyl-2-methylhexa-2,4-dienoat.
COMPARATIVE EVALUATION OF CONVENTIONAL VERSUS RAPID METHODS FOR AMPLIFIABLE GENOMIC DNA ISOLATION OF CULTURED Azospirillum sp. JG3
Authors: Ethica Stalis Norma , Nataningtyas Dilin Rahayu , Lestari Puji , Istini Istini , Semiarti Endang , Widada Jaka , Raharjo Tri Joko
Published: March 2017

As an initial attempt to reveal genetic information of Azospirillum sp. JG3 strain, which is still absence despite of the strains' ability in producing valued enzymes, two groups of conventional methods: lysis-enzyme and column-kit; and two rapid methods: thermal disruption and intact colony were evaluated. The aim is to determine the most practical method for obtaining high-grade PCR product using degenerate primers as part of routine-basis protocols for studying the molecular genetics of the Azospirillal bacteria. The evaluation includes the assessment of electrophoresis gel visualization, pellet appearance, preparation time, and PCR result of extracted genomic DNA from each method. Our results confirmed that the conventional methods were more superior to the rapid methods in generating genomic DNA isolates visible on electrophoresis gel. However, modification made in the previously developed DNA isolation protocol giving the simplest and most rapid method of all methods used in this study for extracting PCR-amplifiable DNA of Azospirillum sp. JG3. Intact bacterial cells (intact colony) loaded on electrophoresis gel could present genomic DNA band, but could not be completely amplified by PCR without thermal treatment. It can also be inferred from our result that the 3 to 5-min heating in dH2O step is critical for the pre-treatment of colony PCR of Azospirillal cells.
IMPRINTING ZEOLITE-MODIFIED GLASSY CARBON AS A VOLTAMMETRIC SENSOR FOR URIC ACID
Authors: Khasanah Miratul , Harsini Muji , Widati Alfa Akustia
Published: March 2017

Development of the uric acid sensor through coating of glassy carbon (GC) electrode with imprinting zeolite (IZ) was carried out. Zeolite was synthesized by mixing TEOS, TBOT, TPAOH, and water followed by hydrothermal process. Zeolite was molded together with uric acid to produce IZ. The deposition potential of IZ and uric acid to the GC surface was -0.6 V during 150 sec with addition of KNO3 0.02 M as supporting electrolyte. The method gives linearity of 0.9834 (concentration 5.6x10-9M - 2.8x10-8 M), precision 1.89 - 7.65%, sensitivity 0.33 µA/nM/cm2, limit of detection 5.9x10-9 M, and accuracy 96.26 ± 0.55% (n = 5). The developed sensor showed a high selectivity toward uric acid. The presence of ascorbic acid, creatine, and creatinine with an equal concentration with uric acid did not interfere on the uric acid analysis.
Kinetics and Mechanism of Ni/Zeolite-Catalyzed Hydrocracking of Palm Oil into Bio-Fuel
Authors: Kadarwati Sri , Rahmawati Fitri , Rahayu Puji Eka , Supardi Kasmadi Imam
Published: March 2017

Kinetics and mechanisms of Ni/zeolite-catalyzed cracking reaction of methyl ester palm oil (MEPO) were studied using a continuous flow-fixed bed reactor system at an atmospheric pressure. The catalyst was prepared by wet impregnation method with a solution of nickel nitrate hexahydrate as the precursor and zeolite as carrier. The characteristics of catalyst including active Ni metal content, crystallinity, total acidity, and porosity were evaluated. The reactions were performed with a varied hydrogen flow rate as a carrier gas as well as a reductant and reaction time. Liquid products were analyzed by GC. Analysis by GC-MS was only conducted on a product at hydrogen flow rate with the best conversion. It has been shown that the catalyst has a superior character for hydrocracking reactions of MEPO into green fuel. No considerable effect of hydrogen flow rate on the total conversion was observed. The tests showed that the kinetics of Ni/zeolite-catalyzed cracking reaction followed pseudo-first order kinetics. GC-MS analysis revealed the formation of light hydrocarbon products with C6-C8 of aliphatic and cyclic components without oxygenates. Distribution of the product indicated that the cracking reaction as well as the isomerization of the products of hydrocracking occurred. Thus, Ni/zeolite-catalyzed cracking involved cracking /hydrogenation, isomerization, cyclization, and deoxygenation.
Design of New Potent Insecticides of Organophosphate Derivatives Based on QSAR Analysis
Authors: Mudasir Mudasir , Wibowo Yari Mukti , Pranowo Harno Dwi
Published: March 2017

Design of new potent insecticide compounds of organophosphate derivatives based on QSAR (Quantitative Structure-Activity Relationship) analytical model has been conducted. Organophosphate derivative compounds and their activities were obtained from the literature. Computational modeling of the structure of organophosphate derivative compounds and calculation of their QSAR descriptors have been done by AM1 (Austin Model 1) method. The best QSAR model was selected from the QSAR models that used only electronic descriptors and from those using both electronic and molecular descriptors. The best QSAR model obtained was:Log LD50 = 50.872 - 66.457 qC1 - 65.735 qC6 + 83.115 qO7 (n = 30, r = 0.876, adjusted r2 = 0.741, Fcal/Ftab = 9.636, PRESS = 2.414 x 10-6)The best QSAR model was then used to design in silico new compounds of insecticide of organophosphate derivatives with better activity as compared to the existing synthesized organophosphate derivatives. So far, the most potent insecticide of organophosphate compound that has been successfully synthesized had log LD50 of -5.20, while the new designed compound based on the best QSAR model, i.e.: 4-(diethoxy phosphoryloxy) benzene sulfonic acid, had log LD50 prediction of -7.29. Therefore, the new designed insecticide compound is suggested to be synthesized and tested for its activity in laboratory for further verification.
IN VITRO INHIBITION OF CELERY (Apium graveolens L.) EXTRACT ON THE ACTIVITY OF XANTHINE OXIDASE AND DETERMINATION OF ITS ACTIVE COMPOUND
Authors: Iswantini Dyah , Ramdhani Tuti Hayati , Darusman Latifah K
Published: March 2017

The objective of this study was to determine the inhibition effect of celery extracts toward xanthine oxidase by in vitro method, and its active compounds. Roots and herb of celery were extracted using water and ethanol solvents. Results indicated that the herbal ethanol extract had the highest inhibition effect (91.40%) at 1400 ppm. The components contained in the herbal ethanol extract were then separated by column chromatography using the best eluent (chloroform : ethyl acetate at 7:3). All of the fractions had inhibition effect greater than 50%. The fraction number 4 was the one with the highest inhibition effect followed by fraction 5 with inhibition percentage of both fractions at 200 ppm were 88.62 and 85.44%, respectively. The analysis of the ultraviolet spectrum of fraction 4 showed the presence of π-π* transition which was resulted by the aromatic C=C, -OH, and C-O chromophores, and also showing the n-σ* transition which was given by -C=O chromophore. The infrared spectrum analysis indicated the presence of aromatic -C=C, -OH, and C=O functional groups. Based on the phytochemical assay and both instrumental spectrums, it was thought that the active compounds of fraction 4 and 5 were in the flavonoid group.
3,4-DIHYDROXYBENZOIC ACID AND 3,4-DIHYDROXYBENZALDEHYDE FROM THE FERN Trichomanes chinense L.; ISOLATION, ANTIMICROBIAL AND ANTIOXIDANT PROPERTIES
Authors: Syafni Nova , Putra Deddi Prima , Arbain Dayar
Published: March 2017

3,4-dihydroxybenzoic acid (1) and 3,4-dihydroxybenzaldehyde (2) have been isolated from ethyl acetate fraction of methanolic fractions of leaves, stems and roots of the fern Trichomanes chinense L. (Hymenophyllaceae). These two compounds also showed significant antioxidant using DPPH and antimicrobial activities using the disc diffusion assay.
MOLECULAR CLONING, EXPRESSION AND FUNCTIONAL INTERACTION OF p48 SUBUNIT OF CHICKEN CHROMATIN ASSEMBLY FACTOR 1 WITH HISTONE DEACETYLASE 2 AND HISTONE ACETYLTRANSFERASE 1
Authors: Ahmad Ahyar
Published: March 2017

We cloned and sequenced cDNA encoding p48 subunit of the chicken CAF-1, chCAF-1p48, and histone acetyltransferase-1, chHAT-1 from chicken DT40 cell lines. We showed that the p48 subunit of CAF-1 tightly binds to two regions of chicken histone deacetylase 2, chHDAC-2, located between amino acid residues 82-180 and 245-314, respectively. We also established that two N-terminal, two C-terminal, or one N-terminal and one C-terminal WD repeat motif of chCAF-1p48 are required for this interaction. The GST pulldown assay, involving truncated and missense mutants of chCAF-1p48, revealed not only that a region containing the seventh WD dipeptide motif of chCAF-1p48, comprising amino acids 376-405, binds to chHAT-1 in vitro, but also that mutation of the motif has no influence on the in vitro interaction. We also established that the region, which is located between amino acids 380-408 of chHAT-1 and contains a leucine zipper motif, is required for its in vitro interaction with chCAF-1p48. Mutation on each of four Leu residues in the leucine zipper motif of chHAT-1 causes the disappearance of the interaction with chCAF-1p48. These results should be useful information for understanding the participation of chCAF-1p48 protein as histones chaperone in DNA-utilizing processes, such as replication, recombination, repair and gene expression in DT40 chicken B cell.
SGLT2 Inhibition in the Diabetic Kidney—From Mechanisms to Clinical Outcome
Authors: van Bommel Erik J.M. , Muskiet Marcel H.A. , Tonneijck Lennart , Kramer Mark H.H. , Nieuwdorp Max , van Raalte Daniel H.
Published: March 2017

Diabetic kidney disease not only has become the leading cause for ESRD worldwide but also, highly contributes to increased cardiovascular morbidity and mortality in type 2 diabetes. Despite increased efforts to optimize renal and cardiovascular risk factors, like hyperglycemia, hypertension, obesity, and dyslipidemia, they are often insufficiently controlled in clinical practice. Although current drug interventions mostly target a single risk factor, more substantial improvements of renal and cardiovascular outcomes can be expected when multiple factors are improved simultaneously. Sodium-glucose cotransporter type 2 in the renal proximal tubule reabsorbs approximately 90% of filtered glucose. In type 2 diabetes, the maladaptive upregulation of sodium-glucose cotransporter type 2 contributes to the maintenance of hyperglycemia. Inhibiting these transporters has been shown to effectively improve glycemic control through inducing glycosuria and is generally well tolerated, although patients experience more genital infections. In addition, sodium-glucose cotransporter type 2 inhibitors favorably affect body weight, BP, serum uric acid, and glomerular hyperfiltration. Interestingly, in the recently reported first cardiovascular safety trial with a sodium-glucose cotransporter type 2 inhibitor, empagliflozin improved both renal and cardiovascular outcomes in patients with type 2 diabetes and established cardiovascular disease. Because the benefits were seen rapidly after initiation of therapy and other glucose-lowering agents, with the exception of liraglutide and semaglutide, have not been able to improve cardiovascular outcome, these observations are most likely explained by effects beyond glucose lowering. In this mini review, we present the drug class of sodium-glucose cotransporter type 2 inhibitors, elaborate on currently available renal and cardiovascular outcome data, and discuss how the effects of these agents on renal physiology may explain the data.
Cognitive Radio: Sistim Radio Cerdas
Authors: Alaydrus Mudrik
Published: March 2017

Tuntutan komunikasi nirkabel yang handal dan kapasitas sistim yangtinggi tidak terlepas dari ketersediaan resource berupa spectrumfrekuensi yang cukup. Pemanfaatan spectrum secara efisien yangsemaksimal mungkin dengan interferensi yang bisa ditoleransi adalahtujuan penting sistim radio kognitif. Ada tiga langkah penting dalamradio kognitif, observasi kondisi lapangan, mengambil keputusanmelalui suatu proses optimasi dan men-setting parameter pemancar. Halkunci dalam sistim radio kognitif adalah managemen spectrum yangdinamis, suatu interval frekuensi yang bebas digunakan oleh pengguna,di kala pengguna utamanya (primary user) sedang tidak menggunakan.Penggunaannya tidak terikat pada suatu teknologi tertentu.
Analisis Pertumbuhan Layanan Data Berbasis Ethernet di Wilayah Kota 2
Authors: Asrar Leni Devera
Published: March 2017

PT. X adalah perusahaan yang intensif mengakomodir keinginan konsumen untuk mendapatkan akses informasi. Saat ini perangkat router terbaru yang digunakan adalah Metro Ethernet Network (MEN) yang memiliki kapasitas 80 port dan digunakan pada awal September 2008. Tulisan ini pertama menganalisis pertumbuhan layanan pada periode September 2008-September 2009, dan dengan dasar ini, digunakan untuk mengestimasi penambahan perangkat ethernet jangka waktu 5 tahun ke depan (60 bulan). Beberapa metoda digunakan, diantaranya linear, eksponensial dan polinomial orde 2 dan 3. Dengan analisis ketepatan, dapat ditentukan bahwa perkembangan layanan ethernet adalah y (jumlah port) = 0,091x3-2,322x2+18,38x+6,160, dengan ketelitian hampir 95%. Hasil penelitian menunjukkan jika tidak terjadi perubahan pertumbuhan pelanggan maka penambahan perangkat Ethernet baru dilakukan pada bulan ke 16,seperti halnya jika perubahan pertumbuhan pelanggan diasumsikan sama dengan pertumbuhan penduduk kota Jakarta Utara (2005-2009) yang besarnya 0,32%. Jika perubahan pertumbuhan pelanggan 5%, 10% dan 15% maka penambahan perangkat Ethernet baru dilakukan pada bulan ke 15. Sedangkan pada bulan ke 60 atau Agustus 2013 dengan perubahan pertumbuhan pelanggan 0.32%, 5%, 10% dan 15% maka total perangkat ethernet yang digunakan masing-masing adalah 156 unit, 163 unit, 171 unit dan 179 unit.
Optimasi Parameter Transmisi OFDM pada DVB-T untuk Penerimaan Tetap dan Bergerak
Authors: Arfianto Teguh
Published: March 2017

Standar Televisi digital yang digunakan di PT. M2V merupakan standarTV digital untuk siaran terrestrial yang dikembangkan di Eropa. SistemDVB-T memiliki ketahanan tinggi terhadap berbagai gangguan akibatkondisi kanal yang buruk dengan adanya derau, lintasan jamak, danvariasi daya terima karena fading karena dipadu dengan dua lapis teknikpengodean untuk koreksi sinyal. Dengan menggunakan sistem ini, dalamsetiap frekuensi carier 8 Mhz diisi dengan 8 channel program siaran.DVB-T juga dapat diimplementasikan dalam mode SFN (SingleFrequency Network) di mana suatu operator dapat memasang beberapapemancar dengan frekuensi yang sama tersebar pada suatu area dengantujuan untuk memperluas dan memperbaiki kualitas cakupan tanpa perlumenambah frekuensi. Pada Teknologi DVB-T yang digunakan di M2Vmenggunakan parameter-parameter yang memang berbeda denganTeknologi televisi digital yang dipakai Nexmedia di frekuensi VHFmaupun TVRI di frekuensi UHF. Di M2V telah mengaplikasikan DVBTpada penerimaan bergerak (mobile), dan rencana pengembanganuntuk mengaplikasikan DVB-T pada rumah (fixed), sehingga diperlukanadanya perubahan sistem transmisi. Dalam penelitian ini penulis akanmelakukan analisis parameter transmisi dengan harapan diperolehparameter transmisi yang cocok untuk penerimaan di rumah (fixed) danpenerimaan bergerak (mobile), sehingga dapat membantu rencanapengembangan di M2V.
Optimalisasi Strategi Bisnis Tower Sharing
Authors: Simbar Veronika
Published: March 2017

Persaingan industri bisnis telekomunikasi khususnya layanan TowerSharing yang semakin ketat seiring dengan munculnya pendatangpendatangbaru dalam industri ini, ditambah dengan variasi permintaandari klien, mengharuskan PT. Protelindo sebagai perusahan TowerProvider untuk melakukan optimalisasi strategi bisnis, dengan caramengidentifikasi posisi perusahan terhadap industri; pencapaian apa sajayang telah diperoleh dan yang belum, faktor apa yang kemudianmenjadi penghambat serta langkah apa yang bisa ditempuh untukoptimalisasi dimaksud. Untuk mendukung tujuan analisa tersebutdigunakan Porter Five Forces dan IE Matriks sebagai alat filterisasiMASUKAN untuk mengetahui posisi perusahan, selanjutnya AnalisaSWOT, Matriks BCG dan Strategi Besar yang digunakan sebagai alatuntuk PENCOCOKAN, mencari rekomendasi rekomendasi strategistrategiyang sesuai dengan hasil identifikasi awal, dan untuk tahapanKEPUTUSANnya sendiri digunakan Matriks Perencanaan StrategiKuantitatif, dimana diperoleh Penetrasi Pasar sebagai strategi bisnisyang paling tepat untuk diimplementasikan saat ini oleh PT. Protelindodengan cara meningkatkan promosi, pendekatan ke klien, dan membuat diferensiasi layanan.
Analisa Saluran Transmisi Nonhomogen dengan Metoda Persamaan Integral
Authors: Alaydrus Mudrik
Published: March 2017

Saluran transmisi adalah salah satu komponen penting di teknik elektro,baik untuk mentransmisikan energi ataupun informasi. Saluran transmisiyang memiliki besaran karakteristik yang tidak homogen (nonhomogen)biasa digunakan untuk rangkaian matching, delay equalizer, filter, waveshaping, pemprosesan sinyal analog dan interkoneksi VLSI . Metodapersamaan integral digunakan untuk menganalisa struktur salurantransmisi ini. Metoda persamaan integral yang diimplementasikandengan metoda momen memberikan hasil yang sangat baik. Kasuskanonikal, saluran transmisi homogen dengan dan tanpa kerugian untukkondisi matching dan tidak matching memberikan verifikasi programkomputer yang dikembangkan, bekerja dengan baik, hasil yangdidapatkan sejalan dengan apa yang didapatkan secara teoretis.Pengamatan saluran transmisi nonhomogen melibatkan salurantransmisi dengan besaran karakteristik yang berubah secara perlahandan yang berubah secara mendadak. Analisa struktur filter lolos bawahmemberikan hasil yang secara kualitatif sama dengan yang diberikan dipustaka.
Analisis Penerapan Project Management Information System (PMIS) Menggunakan Metode Technology Acceptance Model (TAM) Studi Kasus PT. INDOSAT, Tbk
Authors: Rizal Arizal
Published: March 2017

Project Management Information System (PMIS) adalah suatu sistem alat dan teknik yang digunakan dalam manajemen proyek untuk menyampaikan informasi. PMIS digunakan untuk membandingkan baseline dengan actual project dari setiap kegiatan, mengelola material dan merecord catatan untuk tujuan pelaporan. PMIS digunakan untuk menggantikan pekerjaan proyek yang selama ini dilakukan secara manual. Masalahnya adalah apakah Project Management Information System yang telah diimplementasikan sekarang ini dapat memenuhi harapan dari Project Implementator ? Apakah PMIS ini dapat membantu mempercepat pekerjaan proyek ?Kendala-kendala selama ini sewaktu melakukan pekerjaan dokumen project adalah delay dalam hal pengumpulan hasil uji terima yang disebabkan oleh jarak pengiriman, banyaknya dokumen yang harus diproses dalam waktu bersamaan, banyaknya lembaran dokumen yang harus melalui proses approval dan inisiasi pejabat terkait, sehingga membutuhkan waktu dan effort yang tidak sedikit. Semua dokumen tersebut dikerjakan secara manual, baik dalam penyusunan maupun pemeriksaan awal. Permasalahan yang terkandung didalam pertanyaan diatas adalah object penelitian yang diharapkan dapat memberikan jawaban. Penelitian dilakukan dengan melakukan survey kepada pemakai PMIS yang sebelumnya menggunakan sistem secara manual. Penelitian ini menggunakan Technology Acceptance Model (TAM). Penggunaan model TAM didasarkan pada kenyataan bahwa sejauh ini TAM merupakan sebuah konsep yang dianggap paling baik dalam menjelaskan perilaku user terhadap sistem teknologi informasi baru. Populasi dalam penelitian ini adalah vendor-vendor yang terkait, staf admin project dan project Manager. Analisa dilakukan dengan SEM (Structural Equation Modelling) dengan software AMOS (Analysis of Moment Structures) version 6.0.
Kajian Strategi Penjualan Femtocell Sebagai Produkt Baru Menggunakan Fuzzy-Logic
Authors: Maharani Sharita
Published: March 2017

Meningkatnya permintaan layanan internet membuat operator seluler harus terus menyediakan kapasitas jaringan untuk memenuhi permintaan tersebut. Masalah baru kemudian muncul, para pengguna layanan internet dan suara tidak dapat mengakses sinyal ketika berada di dalam ruangan. Femtocell adalah suatu produk baru untuk masyarakat Indonesia dan berfungsi membantu kinerja BTS untuk menangani beban traffic data (load data traffic) dalam suatu area yang tidak terjangkau oleh BTS, semisal di dalam ruangan. Metode Fuzzy-logic dengan pendekatan New Product development (NPD) dipilih karena lebih akurat dalam menilai dua kemungkinan atau lebih dibandingkan dengan metode lainnya untuk menganalisa suatu produk baru yang akan diluncurkan ke masyarakat. Dengan merancang skala linguistic untuk rating dan bobot yang berbentuk kurva linguistic angka Fuzzy, yang nantinya digunakan untuk menilai kriteria-kriteria yang telah dibuat. Lalu nilai yang berbentuk bahasa linguistic tersebut ditransformasikan ke dalam bilangan fuzzy untuk mendapatkan FPSR (Fuzzy Possible Success Rating), untuk kemudian digambarkan pada kurva bobot dan rating. Penggambaran FPSR pada kedua kurva tersebut ternyata memiliki hasil yang mendekati sama.
Studi Eksperimen Pengiriman Sinyal Video Real-Time Dengan Aplikasi Skype Mobile Pada Jaringan Nirkabel 802.11 di Tengah Interferensi Kepadatan Lalu Lintas Manusia
Authors: Karya Oki Teguh
Published: March 2017

Penggunaan mobile phone sebagai alat komunikasi sangat demikian pesat peningkatan pengguna serta beragam jenis fungsi yang terdapat didalamnya. Diantara dari sekian banyak aplikasi yang terdapat pada mobile phone adalah Skype berbasis mobile phone OS yang digunakan untuk telekonferensi. Hal yang tidak bisa dilepaskan dari aplikasi ini adalah dibutuhkannya akses jaringan internet yang mumpuni agar aplikasi ini dapat dirasakan maksimal fungsinya. Wi-fi merupakan salahsatu akses internet yang lazim digunakan masyarakat saat ini. Banyak faktor yang menyebabkan akses pada internet yang tersedia tidak selalu memberikan performa yang terbaik, satu diantaranya adalah interferensi. Pada penelitian ini dilakukan sebuah uji coba berupa transmisi sinyal video secara real-time dengan menggunakan aplikasi pada mobile phone yaitu Skype mobile phone OS. Skype ini dijalankan pada jaringan internet wi-fi, yang dipengaruhi atau diinterferensi oleh kehadiran objek (berupa lalu lintas manusia) di sekitar jaringan tersebut. Wireshark digunakan untuk mendapatkan data keandalan jaringan wi-fi yang digunakan atau dikenal dengan QoS. Pada sisi lain EvalVid digunakan untuk mendapatkan data QoE yang dibatasi hanya mendapatkan data PSNR (Peak Signal to Noise Ratio). Video delay time diperhitungkan sebagai acuan kepuasan end user dalam menggunakan layanan konferensi video. Hasil penelitian menunjukan bahwa kepadatan karyawan di dalam ruangan dapat memberikan pengaruh terhadap nilai QoS dan QoE jika kepadatan karyawan itu disertai dengan lalu-lintas karyawan di dalam ruangan tersebut. Namun jika kepadatan karyawan tidak disertai dengan lalu-lintas di dalamnya maka kepadatan karyawan itu sendiri tidak memberikan pengaruh pada parameter yang diukur.
Analisis Perencanaan Jaringan LTE di Pita Frekuensi 3500 MHz dengan Mode TDD dan FDD
Authors: Saputro Dheni Kuncoro Adri
Published: March 2017

Perkembangan telekomunikasi saat ini mengalami kemajuan yangsangat pesat. kemajuan dalam telekomunikasi ini seiring denganpeningkatan jumlah pengiriman data. Hal ini memicu munculnya erabroadband yang dapat mengatasi masalah pengiriman data yang lebihbesar dengan waktu yang lebih cepat. Teknologi LTE (Long TermEvolution) merupakan salah satu teknologi dari era broadband yangdapat menawarkan kecepatan akses data mencapai 100 Mbps atausekitar 4 kali kecepatan teknologi HSPA+. Salah satu hal yang menjadipermasalahan dalam implementasi LTE di Indonesia adalah alokasifrekuensi. LTE memang memberikan beberapa alternatif alokasifrekuensi yang dapat digunakan seperti 700, 850, 900, 1800, 2100 dan2600 MHz dan dengan lebar pita yang dapat disesuaikan yaitu 5, 10, 15dan 20 MHz. Namun pada pita frekuensi tersebut telah dialokasikanuntuk jaringan lain maka frekuensi 3500 MHz dapat diambil sebagaialternatif untuk penerapan LTE. Dalam perencanaan jaringan LTEdikenal mode FDD dan TDD sebagai akses komunikasi antara jaringan(eNB) ke penerima (UE). Dalam penelitian ini dilakukan pemodelan didaerah pulau Batam yang mewakili karakteristik geografis yangberagam di Indonesia, kemudian melakukan pengukuran pada setiapmode dengan disesuaikan lebar bandwidth berdasarkan throughputmelalui pengukuran uplink throughput dan downlink throughputkemudian parameter coverage melalui pengukuran SINR dan RSRPsehingga diperoleh analisa untuk penerapan frekuensi 3500 MHzsebagai frekuensi alternatif untuk perencanaan jaringan LTE diIndonesia.
Analisis Tekno Ekonomi Kelayakan Migrasi Jaringan 2G/3G ke 4G LTE Pada Frekuensi 900 MHz dan 1800 MHz di DKI Jakarta
Authors: Utama Rangga Yudha
Published: March 2017

Tantangan penyediaan jaringan komunikasi nirkabel yang handaldengan kapasitas sistem yang tinggi tidak terlepas dari biaya investasiyang tinggi. Pemanfaatan resource spectrum secara efisien yangsemaksimal mungkin merupakan salah satu solusi untuk mengatasibiaya investasi yang tinggi. Penelitian ini mem-fokuskan pada analisistekno ekonomi implementasi secara co-existance antara jaringan 2G/3Gexisting dan 4G LTE sesuai dengan tingkat prosentase pertumbuhanpelanggan nirkabel layanan data (2015-2019) dengan membandingkanmana yang lebih ekonomis apakah menggunakan resource spektrumfrekuensi di 900MHz atau 1800MHz.Pada penelitian ini model analisa yang digunakan berdasarkan prinsiptekno-ekonomi dengan metoda capacity estimation dan coverageplanning untuk menentukan perancangan teknologi 4G LTE dan metodaDCF untuk menganalisa secara ekonomi dalam mengukur kelayakanbiaya yang dikeluarkan untuk implementasi 4G LTE tersebut denganmemanfaatkan resource spectrum frekuensi secara efisien pada operatorselluler Indosat Ooredoo.Hasil dari penelitian menunjukan bahwa implementasi migrasi jaringan2G/3G ke 4G LTE pada frekuensi 1800MHz menggunakan bandwidth10 MHz dari perhitungan ekonomi menghasilkan hasil yang lebihefisien dan layak untuk di implementasikan. Diperoleh diperoleh nilaiNPV positif sebesar Rp107.749.194.676 dan IRR sebesar 31.07%,dengan nilai Pay Back Period 3 Tahun 6 Bulan. Dibandingkan denganpenggelaran 4G LTE pada frekuensi 900MHz dengan bandwidth 5MHzdiperoleh nilai NPV positif sebesar Rp 61.075.272.890, namun IRRhanya sebesar 1,71% (dibawah suku bunga perbankan), dengan nilaiPay Back Period 4 Tahun 1 Bulan.
The factors influencing auditor independence: The perceptions of auditors in Bahrain
Authors: Albaqali Qasim , Kukreja Gagan
Published: March 2017

The aim of this research is to assess the relationship between the presumed AI influencing factors and AI from the standpoint of auditors in Bahrain. Researchers have continuously identified and assessed several factors that are expected to safeguard AI and objectivity to mitigate the potential threats faced by the audit profession worldwide. As a result of the promising Bahrain Economic Vision 2030 that emphasizes on ‘fairness’ as a one of major principle, the regulators in Bahrain are expected to adopt new measures that enhance the role of auditors in maintaining fairness and transparency. This research hence investigated the subject matter in a way that intended to assess the AI influencing factors in a Bahraini context. The research is quantitative in nature, whereby questionnaires were distributed to a range of auditors representing the audit firms in the Kingdom of Bahrain. Following reliability and validity tests, the responses were analyzed descriptively, along with empirical analysis through using the Multiple Regression Model. The findings signified the substantial role of the audit regulations and related provisions in enhancing AI and impartiality, when compared to other presumed factors. The research recommendations focused on the importance of overseeing the audit firms and accounting professionals through the formation of an independent audit quality board as well as considering the adoption of a joint-audit practice for the listed companies
Perception of collective bargaining and satisfaction with collective bargaining on employees’ job performance
Authors: Babalola Sunday Samson , Ishola Ajibola Abdulrahamon
Published: March 2017

This study explores the influence of collective bargaining and satisfaction with bargaining on employees’ job performance. A structured questionnaire was distributed to selected sample of 181 unionized employees in the public sector organizations. The results revealed two models, with the first model indicating that satisfaction with collective bargaining (β = .56, p < 0.01) was a significant direct predictor of job performance among employees. The second model showed 35% incremental change in employees’ job performance. This indicated that age
(β = .27, p < .01), and educational qualification (β = .58, p < .01) were significant independent predictors of employees job performance. This study showed that collective bargaining process is very critical in determining organizational industrial relations which in turn help to improve job related outcome such as employees’ job performance
A mixed methodology to view internal audits internal control functioning
Authors: Ackermann Christo
Published: March 2017

The purpose of this paper is to holistically examine internal audit’s internal control functioning, by adopting a data transformation triangulation design. This entailed using questionnaire data and transformed qualitative content analysis data, to perform triangulation. It was found that internal audit functions (IAFs) are important role players in assisting audit committees in their internal control oversight responsibility and that a broad range of internal control work is performed by internal audit. However, in the public eye, there is scant information on IAFs’ functioning and a gap exists between what IAFs actually do and what is presented in public annual reports. The methodology used can be useful for future mixed method studies exploring the broad field of internal auditing. The results of this paper can be used as a starting point to create guidance on internal audit disclosure in public reports and to cultivate further research in the area of internal audit disclosure.
Management control systems, culture, and upper echelons – a systematic literature review on their interactions
Authors: Andersen Christian Vium , Lueg Rainer
Published: March 2017

This systematic literature review of 99 empirical studies, between 1926 and 2016, synthesizes evidence on the interaction of management control systems (MCS) with both national culture and corporate culture. We cast our net widely by considering MCS as a package in relation to macro (national), meso (organizational) and micro culture (upper echelon theory). The literature reviewed suggests that evidence on the interaction of culture and MCS is highly fragmented, and only some authors find that culture matters for MCS. The main reason for these inconsistent findings is that studies investigating organizational MCS tend to focus only on one aspect of culture (macro, meso, or micro). This impairs a comprehensive understanding of the MCS-culture relationship. Our main insight is that culture affects MCS, provided that culture is considered as a multi-layered phenomenon that combines internal aspects of culture – e.g., upper echelon theory – with external aspects of culture, e.g., national culture. The contemporary literature mostly limits itself to discussing whether national culture matters for MCS. Hence, this focus is slightly misguided. Future studies should rather inquire which aspects of culture interacts with MCS across varying contexts.
Optimality conditions for invex interval valued nonlinear programming problems involving generalized H-derivative
Authors: Ahmad Izhar , Singh Deepak , Dar Bilal
Published: March 2017

In this paper, some interval valued programming problems are discussed. The
solution concepts are adopted from Wu [7] and Chalco-Cano et al. [34]. By
considering generalized Hukuhara differentiability and generalized convexity
(viz. ?-preinvexity, ?-invexity etc.) of interval valued functions, the KKT
optimality conditions for obtaining (LS and LU) optimal solutions are
elicited by introducing Lagrangian multipliers. Our results generalize the
results of Wu [7], Zhang et al. [11] and Chalco-Cano et al. [34]. To
illustrate our theorems suitable examples are also provided
Expressions and perturbations for the Moore-Penrose inverse of bounded linear operators in Hilbert spaces
Authors: Du Fapeng
Published: March 2017

Let A,X,Y be bounded linear operators. In this paper, we present the explicit
expression for the Moore-Penrose inverse of A-XY. In virtue of the expression
of (A+X)?, we get the upper bounds of ||(A + X)?|| and ||(A + X)?-A?||.
Permutability degrees of finite groups
Authors: Otera D.E. , Russo F.G.
Published: March 2017

Given a finite group G, we introduce the permutability degree of G, as pd(G)
= 1/|G| |L(G)| ?X?L(G)|PG(X)|, where L(G) is the subgroup lattice of G and
PG(X) the permutizer of the subgroup X in G, that is, the subgroup generated
by all cyclic subgroups of G that permute with X ? L(G). The number pd(G)
allows us to find some structural restrictions on G. Successively, we
investigate the relations between pd(G), the probability of commuting
subgroups sd(G) of G and the probability of commuting elements d(G) of G.
Proving some inequalities between pd(G), sd(G) and d(G), we correlate these
notions.
Asymptotic analysis of the lubrication problem with nonstandard boundary conditions for microrotation
Authors: Pazanin Igor
Published: March 2017

The purpose of this paper is to propose a new effective model describing
lubrication process with incompressible micropolar fluid. Instead of usual
zero Dirichlet boundary condition for the microrotation, we consider more
general (and physically justified) type of boundary condition at the
fluid-solid interface, linking the velocity and microrotation through a
so-called boundary viscosity. Starting from the linearized micropolar
equations, we derive the second-order effective model by means of the
asymptotic analysis with respect to the film thickness. The resulting
equations, in the form of the Brinkman-type system, clearly show the
influence of new boundary conditions on the effective flow. We also discuss
the rigorous justification of the obtained asymptotic model.
Partial resection of the splenic cyst using radiofrequency ablation system
Authors: Putnik Srdjan , Ilic Miroslav
Published: March 2017

Introduction. This paper presents a case of a patient with a benign splenic cyst, which was removed by way of partial resection of the spleen. Case outline. The patient?s benign cyst in the lower pole of the spleen was excised using single CooltipTM radiofrequency ablation electrode (Cool-tip RF Ablation System, CovidienTM, Dublin, Ireland). More than half of the spleen was excised without setting stitches to the splenic parenchyma and without any other hemostyptics. This way, the function of the spleen was preserved, which was proven with scintigraphy and computed tomography two years after the intervention. Conclusion. Radiofrequency ablation system with internally cooled needles can be used successfully and without any consequences to the organ, especially in case of large benign splenic cysts, when it is necessary to preserve the function of the spleen.
The case study of binary power plant based on thermoeconomics in Sichuan, China
Authors: Luo Chao , Wang Yongzhen , Gong Yulie , Ma Weibin , Zhao Jun , An Qingsong
Published: March 2017

In China, renewable energy power plant will be built from the year 2016 to 2020, because of CO2 emission assignment and energy company demand. A geothermal power plant will be designed in Sichuan province. The wet temperature 15?C is selected for cooling temperature. Thermoeconomics of geothermal power system are analyzed using the engineering equation solver. The results show that the capacity of binary power system is 3506 kW and optimum vaporizing pressure is 28 bar, the thermal and exergy efficiency is 13% and 45%. The turbine shaft work of flash power system is 2301 kW and the parasitic load is 71 kW, the optimum flash pressures is 0.95 bar, the thermal and exergy efficiency is 7.9% and 34.7%. the total capital investment of binary system is about 9,767,000 US$, the average annual profit is 1,308,000 $/year; the average rate of return is 13.39%; the payback period is less than 6 years. Condenser destruction and loss exergy is more than other components in the power system. The geothermal power production cost is 0.04 US$/kWh in Sichuan province.
VEGF-A–Expressing Adipose Tissue Shows Rapid Beiging and Enhanced Survival After Transplantation and Confers IL-4–Independent Metabolic Improvements
Authors: Park Jiyoung , Kim Min , Sun Kai , An Yu Aaron , Gu Xue , Scherer Philipp E.
Published: March 2017

Adipocyte-derived vascular endothelial growth factor-A (VEGF-A) plays a crucial role in angiogenesis and contributes to adipocyte function and systemic metabolism, such as insulin resistance, chronic inflammation, and beiging of subcutaneous adipose tissue. Using a doxycycline-inducible adipocyte-specific VEGF-A–overexpressing mouse model, we investigated the dynamics of local VEGF-A effects on tissue beiging of adipose tissue transplants. VEGF-A overexpression in adipocytes triggers angiogenesis. We also observed a rapid appearance of beige fat cells in subcutaneous white adipose tissue as early as 2 days postinduction of VEGF-A. In contrast to conventional cold-induced beiging, VEGF-A–induced beiging is independent of interleukin-4. We subjected metabolically healthy VEGF-A–overexpressing adipose tissue to autologous transplantation. Transfer of subcutaneous adipose tissues taken from VEGF-A–overexpressing mice into diet-induced obese mice resulted in systemic metabolic benefits, associated with improved survival of adipocytes and a concomitant reduced inflammatory response. These effects of VEGF-A are tissue autonomous, inducing white adipose tissue beiging and angiogenesis within the transplanted tissue. Our findings indicate that manipulation of adipocyte functions with a bona fide angiogenic factor, such as VEGF-A, significantly improves the survival and volume retention of fat grafts and can convey metabolically favorable properties on the recipient on the basis of beiging.
Association Between Diabetes and 1-Year Adverse Clinical Outcomes in a Multinational Cohort of Ambulatory Patients With Chronic Heart Failure: Results From the ESC-HFA Heart Failure Long-Term Registry
Authors: Dauriz Marco , Targher Giovanni , Laroche Cécile , Temporelli Pier Luigi , Ferrari Roberto , Anker Stephan , Coats Andrew , Filippatos Gerasimos , Crespo-Leiro Maria , Mebazaa Alexandre , Piepoli Massimo F. , Maggioni Aldo P. , Tavazzi Luigi ,   for the ESC-HFA Heart Failure Long-Term Registry
Published: March 2017

OBJECTIVE

Diabetes mellitus is associated with an increased risk of cardiovascular disease (CVD) and death. Because the prevalence of diabetes is rising worldwide and chronic heart failure (CHF) is becoming increasingly common with the aging population, it is timely to examine the impact of diabetes per se on 1-year adverse outcomes in patients with CHF.

RESEARCH DESIGN AND METHODS

We prospectively assessed whether diabetes status independently affected the 1-year risk of all-cause and CVD mortality and first hospitalization for worsening heart failure (HF) in a multinational cohort of 9,428 outpatients with CHF enrolled in the European Society of Cardiology and Heart Failure Association Long-Term Registry.

RESULTS

Compared with those patients without diabetes, patients with diabetes (n = 3,440, 36.5%) had higher cumulative rates of 1-year all-cause death (9.4% vs. 7.2%; adjusted hazard ratio [HR] 1.28; 95% CI 1.07–1.54), CVD death (4.8% vs. 3.8%; adjusted HR 1.28; 95% CI 0.99–1.66), and HF hospitalization (13.8% vs. 9.3%; adjusted HR 1.37; 95% CI 1.17–1.60), all independent of age, sex, BMI, smoking, systolic blood pressure, estimated glomerular filtration rate, hemoglobin, HF etiology, left ventricular ejection fraction, hypertension, statin use, and prior stroke or chronic obstructive pulmonary disease. Among CHF patients with HbA1c measurements available at baseline (n = 2,567), there was a significant and independent association between increasing HbA1c levels and the risk of 1-year survival outcomes.

CONCLUSIONS

The presence of diabetes markedly increases the risk of 1-year adverse clinical outcomes in outpatients with CHF independent of multiple common risk factors. More effective and personalized treatment for diabetes should be considered in this particularly high-risk patient population.