bluuebunny/crossref_metadata_2025 huggingface dataset:
Management of Combat Casualties during Aeromedical Evacuation from a Role 2 to a Role 3 Medical Facility
Authors: Maddry Joseph K , Araña Allyson A , Mora Alejandra G , Schauer Steven G , Reeves Lauren K , Cutright Julie E , Paciocco Joni A , Perez Crystal A , Davis William T , Ng Patrick C
Published: November 2023

Introduction

Emergent clinical care and patient movements through the military evacuation system improves survival. Patient management differs when transporting from the point-of-injury (POI) to the first medical treatment facility (MTF) versus transporting from the Role 2 to the Role 3 MTF secondary to care rendered within the MTF, including surgery and advanced resuscitation. The objective of this study was to describe care provided to patients during theater inter-facility transports and compare with pre-hospital transports (POI to first MTF).

Materials and Methods

We performed a retrospective chart review of patients with the Role 2 to the Role 3 transports in Afghanistan and Iraq from 2007 to 2016. Data collected included procedures and events at the MTF and during transport. We compared the intra-theater transport data (Role 2 to Role 3) to data from a previous study evaluating pre-hospiital transports (POI to first MTF).

Results

We reviewed the records of 869 Role 2 to Role 3 transport patients. Role 2 to Role 3 transports were longer in duration compared to POI transports (39 minutes vs. 23 minutes) and were more likely to be staffed by advanced personnel (nurses, physician assistants, and physicians) (57% vs. 3%). The sample primarily consisted of military-aged males (mean age 27 years) who suffered from explosive or blunt force injuries. Procedures performed during each phase of care reflected the capabilities of the teams and locations. Pain and cardiac events were more common in POI evacuations compared to the Role 2 to Role 3 transports, but documentation of respiratory events, hemodynamic events, neurologic events, and equipment failure was more common during the Role 2 to Role 3 transports. Survival rates were slightly higher among the Role 2 to Role 3 cohort (98% vs. 95%, difference 3% [95% confidence interval of the difference 1-5%]).

Conclusions

Inter-facility transports (Role 2 to Role 3) are longer in duration, transport more complex patients, and are staffed by more advanced level provider types compared to transports from POI.
Use of Prize Competitions to Develop Advanced Military Medical Capabilities
Authors: White Tonya Y , Walter Scott F
Published: November 2023

Research and development of military-required innovations are usually funded through the issuance of grants and contracts. The limitations of these funding methods are the a priori specifications and objectives that limit creativity and often do not produce capabilities beyond the desired outcomes or leverage the best ideas and solutions available. This limited engagement of commercial industry to develop military-required innovations usually relies solely on government funding and receipt of proposals from companies whose business model is built on receiving government grants and contracts, with the government owning most of the risks. Because the produced capabilities or products are designed to be military-unique, there is a limited or no commercial market available, usually driving the price per unit extremely high to the point that the military cannot afford to procure products in quantities sufficient to enable businesses to keep production lines open, however, for military-required or desired capabilities or products that have a commercial market, there are other funding pathways available to develop products by partnering with industry, academia, and other non-government organizations and leveraging their ideas and funding. One such way of engaging the commercial industry is through the use of prize competitions. This often under-utilized pathway has several notable strengths such as (1) reduced risks and costs for the military to develop novel capabilities and products; (2) new and novel creative solutions to solve military problems; (3) utilizing a results-oriented approach that funds the successful achievement of acceptance criteria versus funding of potential to achieve; (4) enticing investors by increased competition for a successful product or capability; and (5) delivery of a commercially available, affordable, field-tested, and viable capabilities and products. Prize competitions may be used by any/all federal agencies as authorized by Congressional Public Laws and Federal regulations. The specifics of this pathway for funding pathway and applications for use by medical researchers, developers, and project/program managers are spelled out in the article, along with the regulatory guidance and resources for finding out more about current and past prize competitions.
A Lack of Generalizability—Total Knee Demographics in the Active Duty Population
Authors: Olsen Aaron A , Junge Joshua M , Booth Greg , Abraham Vivek M , Balazs George C , Goldman Ashton H
Published: November 2023

Introduction

Age and sex are known demographic risk factors for requiring revision surgery following primary total knee arthroplasty (TKA). Military service members are a unique population with barriers to long-term follow up after surgery. This study aims to compare demographic data between active duty military personnel and a nationwide sample to identify differences that may impact clinical and economic outcomes.

Methods

A retrospective observational analysis was performed using the Military Health System Data Repository (MDR) and the National Surgical Quality Improvement Program (NSQIP). Databases were queried for patients undergoing primary TKA between January 1, 2015 and December 31, 2020. The MDR was queried for demographic data including age, sex, duty status, facility type, geographic region, history of prior military deployment, history of deployment-related health condition, branch of military service, and military rank. National Surgical Quality Improvement Program was queried for age and sex. Median age between populations was compared with the Mann–Whitney U test, and gender was compared with a chi-squared test.

Results

During the study period, 2,094 primary TKA patients were identified from the MDR, and 357,865 TKA patients were identified from the NSQIP database. Military TKA patients were 79.4% male with a median age of 49.0, and NSQIP TKA patients were 38.9% were male, with a median age of 67. Military TKA patients were significantly more likely to be male (P < .001) and younger (P < .001).

Conclusion

Patients undergoing TKA in the military are younger and more likely to be male compared to national trends. Current evidence suggests these factors may place them at a significant revision risk in the future. The application of quality metrics based on nationwide demographics may not be applicable to military members within the Military Health System.
Genotypic diversity and antifungal susceptibility of Cryptococcus neoformans species complex from China, including the diploid VNIII isolates from HIV-infected patients in Chongqing region
Authors: Zhang Lanyu , Wang Saisai , Hong Nan , Li Muyuan , Liu Yiting , Zhou Tao , Peng Yan , Hu Changhua , Li Xiaoxu , Zhang Zhen , Guo Mengzhu , Cogliati Massimo , Hitchcock Megan , Xu Jianping , Chen Min , Liao Guojian
Published: November 2023

Although previous studies on the genotypic diversity and antifungal susceptibility of the Cryptococcus neoformans species complex (CNSC) isolates from China revealed ST5 genotype isolates being dominant, the information about the CNSC isolates from Chinese HIV-infected patients is limited. In this study, 171 CNSC isolates from HIV-infected patients in the Chongqing region of Southwest China were genotyped using the International Society for Human and Animal Mycology-multilocus sequence typing consensus scheme, and their antifungal drug susceptibilities were determined following CLSI M27-A3 guidelines. Among 171 isolates, six sequence types (STs) were identified, including the dominant ST5 isolates, the newly reported ST15, and four diploid VNIII isolates (ST632/ST636). Moreover, a total of 1019 CNSC isolates with STs and HIV-status information were collected and analyzed from Mainland China in the present study. A minimum spanning analysis grouped these 1019 isolates into three main subgroups, which were dominated by the ST5 clonal complex (CC5), followed by the ST31 clonal complex (CC31) and ST93 clonal complex (CC93). The trend of resistance or decreasing susceptibility of clinical CNSC isolates to azole agents within HIV-infected patients from the Chongqing region is increasing, especially resistance to fluconazole.
Spectropolarimetry of the Type IIP supernova 2021yja: an unusually high continuum polarization during the photospheric phase
Authors: Vasylyev Sergiy S , Yang Yi , Patra Kishore C , Filippenko Alexei V , Baade Dietrich , Brink Thomas G , Hoeflich Peter , Maund Justyn R , Patat Ferdinando , Wang Lifan , Wheeler J Craig , Zheng WeiKang
Published: November 2023

We present six epochs of optical spectropolarimetry of the Type IIP supernova (SN) 2021yja ranging from ∼25 to 95 d after the explosion. An unusually high continuum linear polarization of $p \approx 0.9~{{\ \rm per\ cent}}$ is measured during the early photospheric phase, followed by a steady decrease well before the onset of the nebular phase. This behaviour has not been observed before in Type IIP supernovae (SNe IIP). The observed continuum polarization angle does not change significantly during the photospheric phase. We find a pronounced axis of symmetry in the global ejecta that is shared in common with the Hα and Ca ii near-infrared triplet lines. These observations are consistent with an ellipsoidal geometry. The temporal evolution of the continuum polarization is also compatible with the SN ejecta interacting with aspherical circumstellar matter (CSM), although no spectroscopic features that may be associated with strong interaction can be identified. Alternatively, we consider the source of the high polarization to be an extended hydrogen envelope that is indistinguishable from low-density CSM.
The eROSITA final equatorial-depth survey (eFEDS): host-galaxy demographics of X-ray AGNs with Subaru Hyper Suprime-Cam
Authors: Li Junyao , Silverman John D , Merloni Andrea , Salvato Mara , Buchner Johannes , Goulding Andy , Liu Teng , Arcodia Riccardo , Comparat Johan , Ding Xuheng , Ichikawa Kohei , Imanishi Masatoshi , Kawaguchi Toshihiro , Kawinwanichakij Lalitwadee , Toba Yoshiki
Published: November 2023

We investigate the physical properties, such as star-forming activity, disc versus bulge nature, galaxy size, and obscuration of 3811 SRG/eROSITA-detected AGNs at 0.2 < z < 0.8 in the eFEDS field. Using Subaru Hyper Suprime-Cam imaging data in the grizy bands, we measure the structural and stellar properties for their host galaxies by performing a 2D AGN-host image decomposition. We find that (1) AGNs can contribute significantly to the total optical light down to ${\rm log}\, L_{\rm X}\sim 42.5\ \rm erg\ s^{-1}$, thus ignoring the AGN component can significantly bias the structural measurements; (2) AGN hosts are predominately star-forming galaxies at ${\rm log}\, \mathcal {M}_\star \lesssim 11.3\, \mathrm{M}_\odot$; (3) the bulk of AGNs (64 per cent) reside in galaxies with significant stellar discs ($\rm S\acute{e}rsic$ index n < 2), while their host galaxies become increasingly bulge dominated (n ∼ 4) and quiescent at ${\rm log}\, \mathcal {M}_\star \gtrsim 11.0\, \mathrm{M}_\odot$; (4) the size–stellar mass relation of AGN hosts tends to lie between that of inactive (i.e. non-AGN) star-forming, and quiescent galaxies, suggesting that the physical mechanism responsible for building the central stellar density also efficiently fuel the black hole growth; (5) the hosts of X-ray unobscured AGNs are biased towards face-on systems, suggesting that some of the obscuration of the nuclei could come from galaxy-scale gas and dust. This will bias against the detection of unobscured AGNs in gas-rich star-forming galaxies, which may partly account for the deficiency of star-forming discs as host galaxies for the most massive AGNs (missing star-forming fraction up to $\sim 40{{\ \rm per\ cent}}$). Our results are consistent with a scenario in which the black hole and galaxy transform in structure and star-forming activity while grow in mass, as desired to establish the local $\mathcal {M}_{\rm BH}-\mathcal {M}_{\rm bulge}$ relation.
Optimal metallicity diagnostics for MUSE observations of low-z galaxies
Authors: Easeman Bethan , Schady Patricia , Wuyts Stijn , Yates Robert M
Published: November 2023

The relatively red wavelength range (4800–9300 Å) of the VLT Multi Unit Spectroscopic Explorer (MUSE) limits which metallicity diagnostics can be used; in particular excluding those requiring the [${\rm O\, {\small II}}$]λλ3726,29 doublet. We assess various strong line diagnostics by comparing to sulphur $T_{\rm {\it e}}$-based metallicity measurements for a sample of 671 H ii regions from 36 nearby galaxies from the MUSE Atlas of Disks (MAD) survey. We find that the O3N2 and N2 diagnostics return a narrower range of metallicities that lie up to ∼0.3 dex below $T_{\rm {\it e}}$-based measurements, with a clear dependence on both metallicity and ionization parameter. The N2S2H α diagnostic shows a near-linear relation with the $T_{\rm {\it e}}$-based metallicities, although with a systematic downward offset of ∼0.2 dex, but no clear dependence on ionization parameter. These results imply that the N2S2H α diagnostic produces the most reliable results when studying the distribution of metals within galaxies with MUSE. On sub-H ii region scales, the O3N2 and N2 diagnostics measure metallicity decreasing towards the centres of H ii regions, contrary to expectations. The S-calibration and N2S2H α diagnostics show no evidence of this, and show a positive relationship between ionization parameter and metallicity at $12 + \log (\rm {O/H})$ > 8.4, implying the relationship between ionization parameter and metallicity differs on local and global scales. We also present hiidentify, a python tool developed to identify H ii regions within galaxies from H α emission maps. All segmentation maps and measured emission line strengths for the 4408 H ii regions identified within the MAD sample are available to download.
Nested solitons in two-field fuzzy dark matter
Authors: Luu Hoang Nhan , Mocz Philip , Vogelsberger Mark , May Simon , Borrow Josh , Tye S-H Henry , Broadhurst Tom
Published: November 2023

Dark matter as scalar particles consisting of multiple species is well motivated in string theory where axion fields are ubiquitous. A two-field fuzzy dark matter (FDM) model features two species of ultralight axion particles with different masses, m1 ≠ m2, which is extended from the standard one-field model with $m_a \sim 10^{-22} \, {\rm eV}$. Here we perform numerical simulations to explore the properties of two-field FDM haloes. We find that the central soliton has a nested structure when m2 ≫ m1, which is distinguishable from the generic flat-core soliton in one-field haloes. However, the formation of this nested soliton is subject to many factors, including the density fraction and mass ratio of the two fields. Finally, we study non-linear structure formation in two-field cosmological simulations with self-consistent initial conditions and find that the small-scale structure in two-field cosmology is also distinct from the one-field model in terms of DM halo counts and soliton formation time.
Damping of MHD turbulence in a partially ionized medium
Authors: Hu Yue , Xu Siyao , Arzamasskiy Lev , Stone James M , Lazarian A
Published: November 2023

The coupling state between ions and neutrals in the interstellar medium plays a key role in the dynamics of magnetohydrodynamic (MHD) turbulence, but is challenging to study numerically. In this work, we investigate the damping of MHD turbulence in a partially ionized medium using 3D two-fluid (ions + neutrals) simulations generated with the athenak code. Specifically, we examine the velocity, density, and magnetic field statistics of the two-fluid MHD turbulence in different regimes of neutral-ion coupling. Our results demonstrate that when ions and neutrals are strongly coupled, the velocity statistics resemble those of single-fluid MHD turbulence. Both the velocity structures and kinetic energy spectra of ions and neutrals are similar, while their density structures can be significantly different. With an excess of small-scale sharp density fluctuations in ions, the density spectrum in ions is shallower than that of neutrals. When ions and neutrals are weakly coupled, the turbulence in ions is more severely damped due to the ion-neutral collisional friction than that in neutrals, resulting in a steep kinetic energy spectrum and density spectrum in ions compared to the Kolmogorov spectrum. We also find that the magnetic energy spectrum basically follows the shape of the kinetic energy spectrum of ions, irrespective of the coupling regime. In addition, we find large density fluctuations in ions and neutrals and thus spatially inhomogeneous ionization fractions. As a result, the neutral-ion decoupling and damping of MHD turbulence take place over a range of length-scales.
Supervirial hot phase in Milky Way circumgalactic medium: further evidences
Authors: McClain Rebecca L , Mathur Smita , Das Sanskriti , Krongold Yair , Gupta Anjali
Published: November 2023

Recent discoveries of a supervirial hot phase of the Milky Way circumgalactic medium (CGM) have launched new questions regarding the multiphase structure of the CGM around the Galaxy. We use 1.05 Ms of archival Chandra/high-energy transmission grating observations to characterize highly ionized metal absorption at z = 0 along the line of sight of the quasar NGC 3783. We detect two distinct temperature phases with T$_1 = 5.83^{+0.15}_{-0.07}$ K, warm–hot virial temperature, and T$_2=6.61^{+0.12}_{-0.06}$ K, hot supervirial temperature. The supervirial hot phase coexisting with the warm–hot virial phase has been detected in absorption along only two other sightlines and in one stacking analysis. There is scatter in temperature of the hot as well as warm–hot gas. Similar to previous observations, we detect supersolar abundance ratios of metals in the hot phase, with a Ne/O ratio 2σ above solar mixtures. These new detections continue the mystery of the mechanism behind the supervirial hot phase, but provide evidence that this is a true property of the CGM rather than an isolated observation. The supervirial CGM could hold the key to understanding the physical and chemical history of the Milky Way.
Reconsidering photometric estimation of local star formation environment and its correlation with Type Ia supernova luminosity
Authors: Kim Y-L , Briday M , Copin Y , Hook I , Rigault M , Smith M
Published: November 2023

Recent studies on the environmental dependence of Type Ia supernova (SN Ia) luminosity focus on the local environment where the SN exploded, considering that this is more directly linked to the SN progenitors. However, there is a debate about the local environmental, specifically local star formation rate (SFR), dependence of the SN Ia luminosity. A recent study claims that the dependence is insignificant (0.051 ± 0.020 mag; 2.6σ), based on the local SFR measurement by fitting local ugrizy photometry data. However, we find that this photometric local SFR measurement is inaccurate. We argue this based on the theoretical background of SFR measurement and the methodology used to make that claim with their local ugrizy photometry data, especially due to a limited range of extinction parameters used when fitting the data. Therefore, we reanalyse the same host galaxies with the same fitting code, but with more physically motivated extinction treatments and global ugriz photometry of host galaxies. We estimate global stellar mass and SFR. Then, local star formation environments are inferred by using the method which showed that SNe Ia in globally passive galaxies have locally passive environments, while those in globally star-forming low-mass galaxies have locally star-forming environments. We find that there is significant local environmental dependence of SN Ia luminosities: SNe Ia in locally star-forming environments are 0.072 ± 0.021 mag (3.4σ) fainter than those in locally passive environments, even though SN Ia luminosities have been further corrected by the BEAMS with Bias Corrections method that reduces the size of the dependence.
Swift, NuSTAR, and INTEGRAL observations of the symbiotic X-ray binary IGR J16194-2810
Authors: Bozzo E , Romano P , Ferrigno C , Ducci L
Published: November 2023

We report on a simultaneous observational campaign with both Swift/XRT and NuSTAR targeting the symbiotic X-ray binary (SyXB) IGR J16194-2810. The main goal of the campaign was to investigate the possible presence of cyclotron scattering absorption features in the broad-band spectrum of the source, and help advance our understanding of the process of neutron star formation via the accretion-induced collapse of a white dwarf. The 1–30 keV spectrum of the source, as measured during our campaign, did not reveal the presence of any statistically significant absorption feature. The spectrum could be well described using a model comprising a thermal black-body hot component, most likely emerging from the surface of the accreting neutron star, and a power law with no measurable cut-off energy (and affected by a modest absorption column density). Compared to previous analyses in the literature, we could rule out the presence of a colder thermal component emerging from an accretion disc, compatible with the idea that IGR J16194-2810 is a wind-fed binary (as most of the SyXBs). Our results were strengthened by exploiting the archival XRT and INTEGRAL data, extending the validity of the spectral model used up to 0.3–40 keV and demonstrating that IGR J16194-2810 is unlikely to undergo significant spectral variability over time in the X-ray domain.
Prospective dark matter annihilation signals from the Sagittarius Dwarf Spheroidal
Authors: Venville Thomas A A , Duffy Alan R , Crocker Roland M , Macias Oscar , Tepper-García Thor
Published: November 2023

The Sagittarius Dwarf Spheroidal galaxy (Sgr) is investigated as a target for dark matter (DM) annihilation searches utilizing J-factor distributions calculated directly from a high-resolution hydrodynamic simulation of the infall and tidal disruption of Sgr around the Milky Way. In contrast to past studies, the simulation incorporates DM, stellar and gaseous components for both the Milky Way and the Sgr progenitor galaxy. The simulated distributions account for significant tidal disruption affecting the DM density profile. Our estimate of the J-factor value for Sgr, JSgr = 1.48 × 1010 M$_\odot ^2$ kpc−5 (6.46 × 1016 GeV cm−5), is significantly lower than found in prior studies. This value, while formally a lower limit, is likely close to the true J-factor value for Sgr. It implies a DM cross-section incompatibly large in comparison with existing constraints would be required to attribute recently observed gamma-ray emission from Sgr to DM annihilation. We also calculate a J-factor value using a NFW profile fitted to the simulated DM density distribution to facilitate comparison with past studies. This NFW J-factor value supports the conclusion that most past studies have overestimated the dark matter density of Sgr on small scales. This, together with the fact that the Sgr has recently been shown to emit gamma-rays of astrophysical origin, complicate the use of Sgr in indirect DM detection searches.
Warp and flare of the old Galactic disc as traced by the red clump stars
Authors: Uppal Namita , Ganesh Shashikiran , Schultheis Mathias
Published: November 2023

Our study aims to investigate the outer disc structure of the Milky Way Galaxy using the red clump (RC) stars. We analysed the distribution of the largest sample of RC stars to date, homogeneously covering the entire Galactic plane in the range of 40° ≤ ℓ ≤ 340° and −10° ≤ b ≤ +10°. This sample allows us to model the RC star distribution in the Galactic disc to better constrain the properties of the flare and warp of the Galaxy. Our results show that the scale length of the old stellar disc weakly depends on azimuth, with an average value of 1.95 ± 0.26 kpc. On the other hand, a significant disc flaring is detected, where the scale height of the disc increases from 0.38 kpc in the solar neighbourhood to ∼2.2 kpc at R ≈15 kpc. The flare exhibits a slight asymmetry, with ∼1 kpc more scale height below the Galactic plane as compared to the Northern flare. We also confirm the warping of the outer disc, which can be modelled with Zw = (0.0057 ± 0.0050) [R − (7358 ± 368)(pc)]1.40 ± 0.09sin (ϕ − (− 2${_{.}^{\circ}}$03 ± 0${_{.}^{\circ}}$18)). Our analysis reveals a noticeable north–south asymmetry in the warp, with a greater amplitude observed in the southern direction compared to the northern. Comparing our findings with younger tracers from the literature, we observe an age dependency of both the flare and warp. An increase in flare strength with age suggests the secular evolution of the disc as the preferred mechanism for forming the flare. The increase of the maximum warp amplitude with age indicates that the warp dynamics could be the possible cause of the variation in the warp properties with age.
Planetary entropy production as a thermodynamic constraint for exoplanet habitability
Authors: Petraccone Luigi
Published: November 2023

Any biosphere emerges, lives, and grows producing entropy. Entropy production is a thermodynamic function crucial in the framework of non-equilibrium thermodynamics as it is directly related to the dynamical behaviour of far-from equilibrium systems. The extent of entropy production is proportional to the ability of such systems to dissipate free energy and thus to ‘live’, to evolve, to grow in complexity. Generally, a certain threshold of entropy production must be exceeded for the emergence of complex self-organizing structures. Thus, the entropy production can be considered as the thermodynamic thrust that drives life emergence and evolution. In this perspective, we propose that the value of the planetary entropy production (PEP) can provide a first order estimate of the thermodynamic potential of planetary environment to sustain a complex biosphere. Here we use a simplified approach to evaluate the upper limit to the PEP and to the corresponding free energy as function of stellar temperature and orbital parameters of the planet. We found that only Earth-like planets in the circumstellar habitable zone (CHZ) of G and F stars can have a PEP value higher than the Earth value. Further significant thermodynamic differences exist between the inner and outer edge of the CHZ, with the inner edge being thermodynamically more advantageous for the development of complex biospheres. Interestingly, among the recently proposed habitable exoplanets, the ones belonging to the Hycean planets appear the thermodynamically best candidates.
Towards future challenges in the measurement and modelling of night sky brightness
Authors: Barentine John C , Wallner Stefan , Kocifaj Miroslav
Published: November 2023

In ground-based astronomy, the brightness of the night sky is the limiting factor that determines the efficacy of any particular telescope in terms of detecting faint objects. Proper measurement and monitoring of night sky brightness (NSB) is therefore key to protecting sites of astronomical observatories from light pollution and maximizing their scientific productivity. However, current data sources and modelling approaches exhibit practical shortcomings that significantly limit their utility. By considering the current situation in measuring light pollution, we identify opportunities for improvements. These include defaulting to spatially resolved sky brightness measurements, routinely incorporating spectral information and polarization, and collecting simultaneous meteorological data. Given the acute threat to astronomy posed by rapidly increasing NSB around the world, we argue that the time has come for the standardization of NSB measurement and monitoring methods and protocols.
Measuring distances to galaxies with globular cluster velocity dispersions
Authors: Beasley Michael A , Fahrion Katja , Gvozdenko Anastasia
Published: November 2023

Accurate distances are key to obtaining intrinsic properties of astronomical objects such as luminosity or size. Globular clusters (GCs) follow a well-defined relation between their absolute magnitudes and internal stellar velocity dispersions (σ), offering an independent way to measure distances to their host galaxies via high-resolution spectroscopy. This is reminiscent of the ‘Faber–Jackson’ for elliptical galaxies. However, unlike galaxies, GCs have a very narrow range of mass-to-light ratios and simple star formation histories. Here, we show that the GC MV−log10(σ) relation is linear, whose slope is identical for the Milky Way and M31 GC systems. Based on this, we use 94 Milky Way GCs which have distances from GAIA parallaxes, or proper-motion dispersion profiles to derive a ‘GC velocity dispersion’ distance (GCVD) to M31, obtaining (m − M)0 = 24.51 ± 0.08 (d = 798 ± 28 kpc), in excellent agreement with independent measurements. Combining data for these two galaxies to create a fiducial relation using 296 GCs with high-quality measurements, we obtain a zero-point uncertainty (±0.06 mag) corresponding to a distance uncertainty of $\sim 3~{{\ \rm per\ cent}}$. We then use GCVD to obtain a distance to the giant elliptical galaxy NGC 5128 (Centaurus A), finding (m − M)0 = 27.95 ± 0.09 (d = 3.89 ± 0.16 Mpc). This is in excellent agreement with, and in some cases more precise than, literature estimates from the tip of the red giant branch or surface brightness fluctuations. We apply GCVD to Local Group galaxies with appropriate data and find good agreement with literature values even in cases with only one GC velocity dispersion measurement.
Clouds of Theseus: long-lived molecular clouds are composed of short-lived H2 molecules
Authors: Jeffreson Sarah M R , Semenov Vadim A , Krumholz Mark R
Published: November 2023

We use passive gas tracer particles in an Arepo simulation of a dwarf spiral galaxy to relate the Lagrangian evolution of star-forming gas parcels and their H2 molecules to the evolution of their host giant molecular clouds. We find that the median chemical lifetime of H2 is 4 Myr, with an interquartile range between 2 and 9 Myr. This chemical lifetime is independent of the lifetime of the host molecular cloud, which may extend up to 90 Myr, with around 50 per cent of star formation occurring in longer lived clouds (>25 Myr). The rapid ejection of gas from around young massive stars by early stellar feedback is responsible for the short H2 survival time, driving down the density of the surrounding gas, so that its H2 molecules are dissociated by the interstellar radiation field. This ejection of gas from the H2-dominated state is balanced by the constant accretion of new gas from the galactic environment, constituting a ‘competition model’ for molecular cloud evolution. Gas ejection occurs at a rate that is proportional to the molecular cloud mass, so that the cloud lifetime is determined by the accretion rate, which may be as high as 4 × 104 M⊙ Myr−1 in the longest lived clouds. Our findings therefore resolve the conflict between observations of rapid gas ejection around young massive stars and observations of long-lived molecular clouds in galaxies. We show that the fastest-accreting, longest lived, highest mass clouds drive supernova clustering on sub-cloud scales, which in turn is a key driver of galactic outflows.
Nature of 4FGL J1838.2+3223: A flaring ‘spider’ pulsar candidate
Authors: Zyuzin D A , Kirichenko A Yu , Karpova A V , Shibanov Yu A , Zharikov S V , Gilfanov M R , Perez Tórtola C
Published: November 2023

An unidentified γ-ray source 4FGL J1838.2+3223 has been proposed as a pulsar candidate. We present optical time-series multiband photometry of its likely optical companion obtained with the 2.1-m telescope of Observatorio Astronómico Nacional San Pedro Mártir, Mexico. The observations and the data from the Zwicky Transient Facility revealed the source brightness variability with a period of ≈4.02 h likely associated with the orbital motion of the binary system. The folded light curves have a single sine-like peak per period with an amplitude of about three magnitudes accompanied by fast sporadic flares up to one magnitude level. We reproduce them modelling the companion heating by the pulsar. As a result, the companion side facing the pulsar is strongly heated up to 11300 ± 400 K, while the temperature of its back side is only 2300 ± 700 K. It has a mass of 0.10 ± 0.05 M⊙ and underfills its Roche lobe with a filling factor of $0.60^{+0.10}_{-0.06}$. This implies that 4FGL J1838.2+3223 likely belongs to the ‘spider’ pulsar family. The estimated distance of ≈3.1 kpc is compatible with Gaia results. We detect a flare from the source in X-rays and ultraviolet using Swift archival data and another one in X-rays in the eROSITA all-sky survey. Both flares have X-ray luminosity of ∼1034 erg s−1 which is two orders of magnitude higher than the upper limit in quiescence obtained from eROSITA assuming spectral shape typical for spider pulsars. If the spider interpretation is correct, these flares are among the strongest observed from non-accreting spider pulsars.
Unipolar solar flares as a manifestation of ‘topological’ magnetic reconnection
Authors: Dumin Yurii V , Somov Boris V
Published: November 2023

Solar flares – the most prominent manifestation of solar activity – typically manifest themselves as a single or a set of luminous arcs (magnetic flux tubes) rooted in regions of opposite polarity in the photosphere. However, a careful analysis of archival data from the Hinode satellite reveals occasional surprising cases of flaring arcs whose footpoints belong to regions of the same polarity or to areas without any appreciable magnetic field. Despite the counterintuitive nature of this phenomenon, it can be reasonably interpreted in the framework of the so-called ‘topological model’ of magnetic reconnection, whereby a magnetic null point is formed owing to a specific superposition of influences from remote sources rather than by local current systems. As a result, the energy release propagates along the separator of a flipping two-dome structure rather than along a fixed magnetic field line. Therefore, the luminous arc no longer needs to be associated immediately with the magnetic sources. Here, we report observational cases of the above-mentioned type and provide a theoretical model and numerical simulations.
Higher beta-hydroxybutyrate ketone levels associated with a slower kidney function decline in ADPKD
Authors: Knol Martine G E , Bais Thomas , Geertsema Paul , Connelly Margery A , Bakker Stephan J L , Gansevoort Ron T , van Gastel Maatje D A ,   the DIPAK Consortium, Drenth J P H , de Fijter J W , Peters D J M , Salih M , Hoorn E J , Nijenhuis T , Meijer E
Published: November 2023

Background

Dysregulated energy metabolism is a recently discovered key feature of autosomal dominant polycystic kidney disease (ADPKD). Cystic cells depend on glucose and are poorly able to use other energy sources such as ketone bodies. Raising ketone body concentration reduced disease progression in animal models of polycystic kidney diseases. Therefore, we hypothesized that higher endogenous plasma beta-hydroxybutyrate (BHB) concentrations are associated with reduced disease progression in patients with ADPKD.

Methods

We analyzed data from 670 patients with ADPKD participating in the Developing Intervention Strategies to Halt Progression of ADPKD (DIPAK) cohort, a multi-center prospective observational cohort study. BHB was measured at baseline using nuclear magnetic resonance spectroscopy. Participants were excluded if they had type 2 diabetes, were using disease-modifying drugs (e.g. tolvaptan, somatostatin analogs), were not fasting or had missing BHB levels, leaving 521 participants for the analyses. Linear regression analyses were used to study cross-sectional associations and linear mixed-effect modeling for longitudinal associations.

Results

Of the participants, 61% were female, with an age of 47.3 ± 11.8 years, a height-adjusted total kidney volume (htTKV) of 834 [interquartile range (IQR) 495–1327] mL/m and an estimated glomerular filtration rate (eGFR) of 63.3 ± 28.9 mL/min/1.73 m2. The median concentration of BHB was 94 (IQR 68–147) µmol/L. Cross-sectionally, BHB was associated neither with eGFR nor with htTKV. Longitudinally, BHB was positively associated with eGFR slope {B = 0.35 mL/min/1.73 m2 [95% confidence interval (CI) 0.09 to 0.61], P = .007}, but not with kidney growth. After adjustment for potential confounders, every doubling in BHB concentration was associated with an improvement in the annual rate of eGFR by 0.33 mL/min/1.73 m2 (95% CI 0.09 to 0.57, P = .008).

Conclusion

These observational analyses support the hypothesis that interventions that raise BHB concentration could reduce the rate of kidney function decline in patients with ADPKD.
Evolution of Influenza A(H3N2) Viruses in 2 Consecutive Seasons of Genomic Surveillance, 2021–2023
Authors: Fall Amary , Han Lijie , Yunker Madeline , Gong Yu-Nong , Li Tai-Jung , Norton Julie M , Abdullah Omar , Rothman Richard E , Fenstermacher Katherine Z J , Morris C Paul , Pekosz Andrew , Klein Eili , Mostafa Heba H
Published: November 2023

Background

The circulation and the genomic evolution of influenza A(H3N2) viruses during the 2021/2022 and 2022/2023 seasons were studied and associated with infection outcomes.

Methods

Remnant influenza A–positive samples following standard-of-care testing from patients across the Johns Hopkins Health System (JHHS) were used for the study. Samples were randomly selected for whole viral genome sequencing. The sequence-based pEpitope model was used to estimate the predicted vaccine efficacy (pVE) for circulating H3N2 viruses. Clinical data were collected and associated with viral genomic data.

Results

A total of 121 683 respiratory specimens were tested for influenza at JHHS between 1 September 2021 and 31 December 2022. Among them, 6071 (4.99%) tested positive for influenza A. Of these, 805 samples were randomly selected for sequencing, with hemagglutinin (HA) segments characterized for 610 samples. Among the characterized samples, 581 were H3N2 (95.2%). Phylogenetic analysis of HA segments revealed the exclusive circulation of H3N2 viruses with HA segments of the 3C.2a1b.2a.2 clade. Analysis of a total of 445 complete H3N2 genomes revealed reassortments; 200 of 227 of the 2022/2023 season genomes (88.1%) were found to have reassorted with clade 3C.2a1b.1a. The pVE was estimated to be −42.53% for the 2021/2022 season and 30.27% for the 2022/2023 season. No differences in clinical presentations or admissions were observed between the 2 seasons.

Conclusions

The increased numbers of cases and genomic diversity of influenza A(H3N2) during the 2022/2023 season were not associated with a change in disease severity compared to the previous influenza season.
Characterizing juvenile dispersal dynamics of invasive Barred Owls: Implications for management
Authors: Watson Whitney A , Hofstadter Daniel F , Jones Gavin M , Kramer H Anu , Kryshak Nicholas F , Zulla Ceeanna J , Whitmore Sheila A , O’Rourke Virginia , Keane John J , Gutiérrez R J , Peery M Zachariah
Published: November 2023

Characterizing natal dispersal can help manage the spread of invasive species expanding their ranges in response to land use and climate change. The Barred Owl (Strix varia) is a prominent example of an apex predator undergoing a rapid range expansion, having spread from eastern to western North America where it is now hyperabundant—threatening the Northern Spotted Owl (Strix occidentalis caurina) with extinction and potentially endangering many other native species. We attached satellite tags to 31 Barred Owl juveniles at the southern leading edge of the Barred Owl’s expanding range in California to characterize natal dispersal patterns and inform management. Juveniles traveled up to 100 km from natal territories and experienced high mortality (annual survival = 0.204). At landscape scales, juveniles preferentially used forests, shrublands, and lower elevations during dispersal and avoided grasslands and burned areas. At finer scales, juveniles preferred shorter (younger) forests, lower elevations, and drainages, and avoided unforested areas. Our results suggest that the Barred Owl range expansion is being driven primarily by high reproductive rates and densities despite low juvenile survival rates and dispersal through putatively suboptimal younger forests as a result of exclusion from high-quality habitat by territorial individuals. These findings also point to several strategies for conserving Spotted Owls and other native species in the Barred Owl’s expanded range, including: (1) creating and maintaining Barred Owl-free reserves bounded by open or high elevation areas, (2) creating reserves large enough to reduce immigration by long-distance dispersers, and (3) removing Barred Owls from large riparian corridors.
Magnolia Warbler flight calls demonstrate individuality and variation by season and recording location
Authors: Ress Elliott M , Farnsworth Andrew , Morris Sara R , Lanzone Michael , Van Doren Benjamin M
Published: November 2023

Flight calls are short vocalizations frequently associated with migratory behavior that may maintain group structure, signal individual identity, and facilitate intra- and interspecific communication. In this study, Magnolia Warbler (Setophaga magnolia) flight call characteristics varied significantly by season and recording location, but not age or sex, and an individual’s flight calls were significantly more similar to one another than to calls of other individuals. To determine if flight calls encode traits of the signaling individual during migration, we analyzed acoustic characteristics of the calls from the nocturnally migrating Magnolia Warbler. Specifically, we analyzed calls recorded from temporarily captured birds across the northeastern United States, including Appledore Island in Maine, Braddock Bay Bird Observatory in New York, and Powdermill Avian Research Center in Pennsylvania to quantify variation attributable to individual identity, sex, age, seasonality, and recording location. Overall, our findings suggest that Magnolia Warbler flight calls may show meaningful individual variation and exhibit previously undescribed spatiotemporal variation, providing a basis for future research.
Conserved serine phosphorylation regulates histone deacetylase activity in Arabidopsis and humans
Authors: Liu Xiaojing , Cheng Weijia , Yao Peng , Ren Kexin , Wang Yu , Sun Yingnan , Hou Xin , Lu Li , Chen Xiangsong
Published: November 2023

Conserved serine phosphorylation regulates histone deacetylase activity in Arabidopsis and humans
Arabidopsis FIBRILLIN6 influences carotenoid biosynthesis by directly promoting phytoene synthase activity
Authors: Iglesias-Sanchez Ariadna , Navarro-Carcelen Juan , Morelli Luca , Rodriguez-Concepcion Manuel
Published: November 2023

Carotenoids are health-promoting plastidial isoprenoids with essential functions in plants as photoprotectants and photosynthetic pigments in chloroplasts. They also accumulate in specialized plastids named chromoplasts, providing color to non-photosynthetic tissues such as flower petals and ripe fruit. Carotenoid accumulation in chromoplasts requires specialized structures and proteins such as fibrillins (FBNs). The FBN family includes structural components of carotenoid sequestering structures in chromoplasts and members with metabolic roles in chloroplasts and other plastid types. However, the association of FBNs with carotenoids in plastids other than chromoplasts has remained unexplored. Here, we show that Arabidopsis (Arabidopsis thaliana) FBN6 interacts with phytoene synthase (PSY), the first enzyme of the carotenoid pathway. FBN6, but not FBN4 (a FBN that does not interact with PSY), enhances the activity of plant PSY (but not of the bacterial PSY crtB) in Escherichia coli cells. Overexpression of FBN6 in Nicotiana benthamiana leaves results in a higher production of phytoene, the product of PSY activity, whereas loss of FBN6 activity in Arabidopsis mutants dramatically reduces the production of carotenoids during seedling de-etiolation and after exposure to high light. Our work hence demonstrates that FBNs promote not only the accumulation of carotenoids in chromoplasts but also their biosynthesis in chloroplasts.
A new fossil frog (Lissamphibia: Anura) from the Late Cretaceous of Brazil and the early evolution of neobatrachians
Authors: Santos Rodolfo Otávio , Carvalho Alberto B , Zaher Hussam
Published: November 2023

Although neobatrachians represent about 95% of anuran diversity, their fossil record, especially during the Mesozoic, remains scarce and often limited to a few damaged specimens with uncertain affinities. In South America, fossil neobatrachians have been identified from the Cretaceous deposits in Chile, Argentina, and Brazil. Here, we describe a new species of fossil neobatrachian from the Late Cretaceous (Campanian) Bauru Basin, south-eastern Brazil, based on several well-preserved specimens. The morphology of the new species was described in detail using high-resolution micro-CT, and its taxonomic affinities were investigated through a phylogenetic analysis encompassing both living and extinct taxa. The new taxon was recovered among hyloids, more specifically as closely related to other well-ossified taxa. However, due to the lack of any synapomorphies with extant families, we were unable to assign the new species to a more specific group within Neobatrachia. The discovery of a new fossil frog in the Late Cretaceous Bauru Basin significantly enhances our understanding of neobatrachian early morphology during the Late Cretaceous of South America.
Information Transfer Among Grape Producers in the Western United States on Pest and Disease Management
Authors: Lowder Sarah R. , Moyer Michelle M. , Cooper Monica L. , Pscheidt Jay W. , Mahaffee Walter F.
Published: November 2023

Knowledge about how producers subjectively assess and communicate about different information resources can help optimize Agricultural Extension efforts. In particular, how do growers use different information resources when making decisions on pest and disease management? Using pest and disease management in wine grapes ( Vitis vinifera) as a case study, three surveys were conducted among grape producers in the western United States to qualitatively explore resource options ( n = 15), examine the relative importance of the 23 different information resources identified ( n = 63), and investigate the social networks where information is passed within and between regions ( n = 65). Five different informational archetypes emerged, demonstrating different preferences for information resource use, which explained 66% of the variance in survey responses. Personal connections (e.g., discussion with professional network, with field foreman and supervisors, and with an Extension agent) were extremely important to the participants. In the communication network analysis, 65 participants were used to form a 324-actor network with 448 links, which were then subdivided into intra-state networks. The networks show evidence of structures that facilitate information diffusion and cooperation between independent producers. Additionally, even with networks much smaller than the grape producer populations in these states, influential individuals could be identified. These individuals, when targeted by outreach professionals, could assist with information dissemination and facilitate changes in opinion or behaviors in the region.

[Formula: see text] The author(s) have dedicated the work to the public domain under the Creative Commons CC0 “No Rights Reserved” license by waiving all of his or her rights to the work worldwide under copyright law, including all related and neighboring rights, to the extent allowed by law, 2024.