bluuebunny/crossref_metadata_2025 huggingface dataset:
Estrategias no farmacológicas como adyuvantes para manejo del dolor agudo por punción en pediatría
Authors: Call Orellana Francisco Alfredo , Tejada Alvanés José Ernesto , Handal Acosta José Javier , García Meléndez Zayri Geraldine
Published: July 2022

El dolor en pediatría es un problema de salud pública que afecta al 78 % de pacientes hospitalizados y está frecuentemente asociado a punciones, por lo que es necesario un control rápido y efectivo. Existen en la actualidad estrategias psicológicas y físicas de estimulación sensorial para abordarlo. Se pretende describir el uso de estas como coadyuvantes en el manejo del dolor agudo por punción en pediatría. Se realizó una revisión narrativa de artículos originales y revisiones bibliográficas. El mecanismo del dolor involucra a las fibras C y a las fibras Aδ, que responden al dolor por punción. Entre las estrategias innovadoras se encuentra el dispositivo Buzzy®, que actúa mediante la teoría de compuerta del dolor, desviando la atención del dolor hacia un estímulo sensorial placentero (frío y vibración) que disminuye la intensidad en comparación con anestésicos locales (p < 0,001); así mismo, la realidad virtual desvía la atención del niño hacia un estímulo placentero, visual o auditivo, creando un ambiente tridimensional y produciendo analgesia por distracción en comparación al control (p < 0,05). El uso de estrategias no farmacológicas como coadyuvantes para el manejo de dolor por punción son efectivas para disminuir el dolor en el paciente pediátrico, así como el estrés y la ansiedad, tanto en los padres como en el personal de salud.
Infección por SARS-CoV-2 posterior a la inmunización artificial e híbrida en el personal de salud
Authors: López Contreras José Eduardo , Castillo Velez Francisco Eduardo , Murguía Gutiérrez Gustavo , Sepúlveda Marrón Jocelin , Sánchez Martínez Eduardo Pablo , Paredes Casillas Patricia
Published: July 2022

Introducción. Reportes actuales sugieren que el antecedente de infección por SARS -CoV-2 y completar un esquema de vacunación otorga mayor protección contra la presentación sintomática de COVID-19. Objetivo. Comparar el riesgo de enfermar de COVID-19 entre el personal de salud con esquema completo de vacuna contra SARS -CoV-2 BNT162b2 y el antecedente de infección por SARS -CoV-2. Metodología. Estudio de cohorte histórica en 1874 trabajadores de la salud del Nuevo Hospital Civil de Guadalajara inmunizados con la vacuna BNT162b2 entre enero y marzo de 2021. Después de seis meses de seguimiento, el grupo de no expuestos (sin antecedente de infección) fue de 1397 y el grupo expuesto (con antecedente de infección), de 477 sujetos. Resultados. La incidencia de infección por SARS -CoV-2 fue de 39 casos. El riesgo de infección en la cohorte posterior a la inmunización fue de 0,021. El grupo de inmunización híbrida presentó un riesgo menor de infección comparado con el grupo de inmunización artificial (0,015 y 0,243). La inmunización híbrida contribuyó a una reducción del riesgo atribuible a la población de 0,003 (R0 0,024; Rp 0,020). La hospitalización se presentó en el 7,69 % de los casos confirmados con SARS -CoV-2. El riesgo de hospitalización en inmunización híbrida es de 0,210 y de 0,143 en el grupo de inmunización artificial (RR 1,46 IC95 % 0,13 -16,11). Conclusión. La inmunización híbrida podría contribuir a reducir el riesgo de infección por SARS -CoV-2, potenciando la inmunidad generada por la vacuna contra COVID-19.
Investigating the moderating effect of operational risk on the relationship between social responsibility and cost of equity capital in companies listed on Tehran stock exchange
Authors: Sotoudeh Reza , Fard Tehran Fereshteh Nami , Samet Hossein
Published: July 2022

This study investigates the relationship between social responsibility and cost of equity capiral and the moderating effect of operational risk on the mentioned relationship. The study covers a 6-year research period during 2014 to 2019. 146 firms (total of 876 year-firm) are selected as the statistical sample using systematic elimination sampling method. The hypotheses are analyzed using multivariate regression models and panel data methods are also applied. The results indicate there is a significant negative relationship between social responsibility and cost of equity capital. The operational risk has a significant and inverse effect on the relationship between social responsibility and cost of equity capital.
Memoria del IV Congreso Universitario de Investigaciones Científicas de la Universidad de El Salvador
Authors: UES SIC
Published: July 2022

El IV Congreso Universitario de Ivestigaciones Centíficas, se llevó a cabo los días 26, 27 y 28 de Octubre del año 2021. La metodología para su desarrollo fue no presencial, dadas las restricciones debido a la COVID-19. Las sesiones fueron transmitidas simultáneamente por Facebook y Youtube con un total de 6 jornadas. Se recibieron un total de 95 ponenicas, de las cuales, se presentaron un total de 87. De las ponencias presentadas 9 corresponden an Ciencias Agríclas y Veterinarias, 11 a Ciencias Médicas y  de la Salud, 23 a Ciencias Naturales, 23 a Ciencias Sociales, 8 a Artes y Humanidades y finalmente 13 a Ingeniería y Tecnología .

Adicional a las ponencias, se contó con 4 conferencias magistrales que fueron presentadas durante el desarrollo de las diferentes jornadas en el orden siguiente: 1) Aportes de la Red Iberoamericana de Medio Ambiente (REIMA) a la Formación Ambiental en América Latina y El Caribe, por Dr. Yordanis Puerta de Armas, referente de REIMA, A.C.; 2) Aportes del Herbario Nacional de El Salvador (MHES) en la identificación de plantas con propiedades oxidantes por Jenny Menívar, del Museo de Historia Natural de El Salvador; 3) Investigación y Docencia. Aspector metodológicos y sociales por el Dr. Raúl Rojas Soriano de la Universidad Autónoma de México y 4) La producción científica en tiempos de pandemia. El papel de la ciencia por la Dra. Xochitl Sandoval del Instituto Nacoional de Salud. Los resúmenes de las primeras dos conferenicas magistrales se incluyen en esta memoria.

El IV Congreso contó con el apoyo de la Red Iberoamericana de Medio Ambiente (REIMA A.C.), el Museo de Historia Natural De El Salvador (MUHNES), el Instituto Nacional de Salud (INS), el Consejo Superior Universitario Centroamericano (CSUCA), el Fondo de Inversión Ambiental De El Salvador (FIAES) y el Organismo Internacional Regional de Sanidad Agropecuaria (OIRSA).
Informe sobre los restos arquitectónicos de la antigua iglesia del Buen Suceso en Madrid, abandonados en el Monte del Pardo
Authors: Comisión de Monumentos y Patrimonio Histórico
Published: July 2022

Habiendo visitado personalmente los restos arquitectónicos de la antigua iglesia del Buen Suceso en Madrid, abandonados en el Monte del Pardo, estudiada la documentación reunida por esta Comisión de Monumentos y Patrimonio Histórico, se aprueba el presente informe por la CMPH de la Real Academia de Bellas Artes de San Fernando que eleva y refrenda el Pleno de la Corporación en su sesión de 14 de marzo de 2022.
Gangrena de Fournier: hallazgos por ecografía. Reporte de caso
Authors: Ramírez Escobar Melissa , Mora Cubides Juan Fernando , Flor Patiño Romel  Antonio
Published: July 2022

La gangrena de Fournier representa una fascitis necrotizante de etiología polimicrobiana. Etiológicamente se ha descrito como una extensión dada por un foco infeccioso primario de estructuras adyacentes, en región perineal, perianal y genital. Esta patología presenta una rápida progresión y alta tasa de mortalidad, por lo que su diagnóstico precoz es fundamental en el abordaje. Se presenta el caso de un paciente con gangrena de Fournier que fue diagnosticado a partir de hallazgos ecográficos y abordado quirúrgicamente con un desenlace favorable.
Hemoperitoneo como complicación de un carcinoma hepatocelular en lóbulo de Riedel. A propósito de un caso
Authors: Zabaleta Arias César Augusto , Neira Sepúlveda Ángela , Martínez Ana M.
Published: July 2022

El hemoperitoneo puede ocurrir en diversas condiciones, entre ellas las tumorales. Se presenta el caso de una paciente de 80 años de edad, con antecedente de hipertensión arterial (HTA), falla cardiaca y accidente cerebrovascular (ACV) que ingresa por dolor abdominal en el flanco derecho; al examen físico se describe una masa palpable, en el estudio tomográfico se caracterizó un hepatocarcinoma asociado al lóbulo hepático de Riedel. A los cinco días sufrió una ruptura hepática parcial con sangrado activo al peritoneo. Falleció como consecuencia de las complicaciones.
Redes neuronales convolucionales: un modelo de Deep Learning en imágenes diagnósticas. Revisión de tema
Authors: Lubinus Badillo Federico , Rueda Hernández César Andrés , Marconi Narváez Boris , Arias Trillos Yhary Estefanía
Published: July 2022

Los avances en la inteligencia artificial han repercutido en varios espacios de la vida cotidiana, así como en la medicina. En vista de la rápida aplicación del aprendizaje profundo —conocido como Deep Learning— en los datos biomédicos, las imágenes radiológicas han comenzado a adoptar esta técnica. En lo que respecta, se espera que el aprendizaje profundo tenga un efecto en el proceso de adquisición e interpretación de imágenes, así como en la toma de decisiones. Esta revisión ofrece en primer lugar una descripción general del funcionamiento de las redes neuronales convolucionales, los conceptos básicos de estas, y las perceptivas actuales en la aplicación médica centrada en imágenes diagnósticas.
Carcinoma escamocelular de vejiga. Reporte de un caso
Authors: Cabarcas Herrera Claudia Isabel , Goenaga Pareja Julio Jesús , Salcedo Brand Juan Fernando , Márquez Florián Dolcey , Vergara Severiche Sindy Claudina , Herrera Bedoya María José
Published: July 2022

El cáncer de vejiga es la causa más común de malignidad del sistema urinario. Dentro de su espectro clínico se puede manifestar como hematuria no dolorosa, síntomas urinarios irritativos (polaquiuria, urgencia, disuria) y obstrucción urinaria, hallazgos que pueden retrasar el diagnóstico debido a sus similares características con otras patologías benignas (infección de tracto urinario, prostatitis, litiasis, hiperplasia prostática benigna). De todas las neoplasias de la vejiga, el carcinoma escamocelular corresponde del 3 al 5 % en Norte América y Europa; el más común es el carcinoma de células transicionales con una frecuencia del 95 %. Se presenta el caso de un hombre de 53 años de edad con dolor abdominal y síntomas urinarios irritativos, en quien los estudios de imagen establecieron el diagnóstico de tumor de vejiga. Se le practicó una cistoscopia transuretral y se recolectaron especímenes para valoración por patología. El estudio histopatológico con análisis histoquímico confirmó el hallazgo de un carcinoma escamocelular de vejiga.
Encuesta InES Ciencia Abierta UCen
Authors: Hartley Ricardo
Published: July 2022

Primera encuesta del proyecto InES Ciencia Abierta UCen, disponible del 20 al 24 de junio
Simulating data with identifiable information
Authors: Klein Richard , Hartgerink Chris
Published: July 2022

This NodeJS script allows for the generation of fake datasets with identifiable information. This attempt to generate synthetic datasets serves the purpose of estimating precision measures of procedures to detect identifiable information in datasets. Please note that the script has the NodeJS dependencies "@faker-js/faker" and "chance" - these can be installed using the supporting file in a folder and running "npm install".
The Influence of the Different Gain Material on the Loss Compensation of Hybrid Plasmonic Waveguide
Authors: Cavaliere Pasquale
Published: July 2022

The influence of different gain materials and waveguide parameters on propagation properties are analyzed in detail. In this paper, three materials including Al2 O3 , Si3 N4 , and Polymethylmethacrylate (PMMA) as low index materials are introduced instead of SiO2 which is used in many experiments. The results obtained via simulations showed that by increasing the width of metal, field confinement increased and for widths larger than 450 nm the filed profile was completely confined in below the metal (zone I). In addition to, simulation results showed that Al2 O3 and Si3 N4 are more efficient than SiO2 whereas PMMA is completely similar to SiO2 in loss compensation. It was attributed to the fact that the refractive index of PMMA is close to the refractive index of SiO2 . Moreover, the effect of InGaAsP as high index gain material instead of Si is analyzed. In this case, InGaAsP also reveals a loss compensation effect similar to Si due to their close refractive indexes. Therefore, the configuration with new different gain materials potentially offers an appealing solution to provide lossless light transport via low compensation gain, hence opening venues for ultra-compact active plasmonic devices.
The Modern Transformation of Pre-qin Confucian Ethics of Responsibility
Authors: Zhao Beixin
Published: July 2022

The pre-Qin Confucian responsibility ethics takes "harmony" as the value appeal, "courtesy" as the system guarantee, and responsibility consciousness as the internal requirement, pursuing the moral realm of "honesty". They have achieved remarkable results in the implementation of the guarantee responsibility, and cultivated a group of people with lofty ideals who take the world as their own responsibility. With the advent of the stranger society, the rapid development of science and technology and the deep popularity of the idea of rights, the pre-Qin Confucian ethics of responsibility will inevitably encounter some challenges in modern times. In the absence of responsibility and the lack of responsibility consciousness of social members are becoming increasingly serious, it is a feasible path for the transformation of traditional Confucian responsibility ethics to establish the concept of benevolence responsibility, adhere to the responsibility standard and give play to the value guiding role of pre-Qin Confucian responsibility ethics.
Insect pollinators of teak (Tectona grandis) in Kerala
Authors: Mohanadas K. , Mathew George , Narendran T.
Published: July 2022

Insects play a major role in pollination of teak. Insect visitation was observed to commence in the morning and continued till noon after which the activity decreased. Maximum insect visit coincided with the anthesis, which occurred from 8 AM to 12 PM. Insects observed on the teak florescence belonged to the orders Hymenoptera, Lepidoptera, Coleoptera, Diptera, Thysanoptera, and Hemiptera. Of these, maximum number of species belonged to Hymenoptera and Lepidoptera. Based on the quantity of pollen carried and potential to effect pollen transfer, the solitary bees, Halictus tectonae Narendran & Joberaj, Nomia ellioti Smith, Anthophora niveocincta Smith and A. zonata Lin. as well as the wasps Eumenes flavopicta Blanch. and Rhynchium brunneum (Smith) were ranked as the most efficient pollinators. When the approach of the pollinators to the teak inflorescence was prevented using nylon nets and cloth bags, that inflorescence showed marked reduction in fruit setting, which indicates the role of insects in pollination of teak.
Uzaktan Sağlık Hizmeti Sunumu-Samsun Örneği
Authors: Öz Hatice
Published: July 2022

Sağlık hizmeti hizmet türünün içeriği gereği diğer hizmet türlerinden ayrılmaktadır. Son dönemde küresel olaylar ve teknolojik gelişmeler hizmet sunumunda değişikliklere neden olmuştur. Uzaktan sağlık hizmeti sağlık hizmet sunumunda bir fırsat olarak karşımıza çıkmıştır. Pandemi süreci kapsamında bulaşın azaltılması ve riskli kişilerin halk sağlığını tehdit etmeden sağlık hizmetlerine ulaşması açısından için Sağlık Bakanlığı, Tele Sağlık Sistemini duyurmuştur. Öncelikle kamu hastanelerinde başlayan bu uygulamanın, birinci basamak sağlık hizmetlerinden aile hekimliği uygulaması süreçlerinin geliştirilmesi amaçlanmıştır. Samsun ili de bu uygulama için pilot il seçilmiştir. Bu hizmetten özellikli izlem gerektiren durumlar, kronik hastalıklar, engelli ve yaşlı bireyler ve evde sağlık hastaları gibi birçok alanda sağlık hizmet sunumundan faydalananlara yönelik deneyimler yapılmıştır. Sonuç olarak hizmetin kişilerin izlem ve takiplerinde kullanılabileceği, aynı zamanda doğru beslenme, kronik yara bakımı, anne sütünün kullanımın artırılması, emzirme eğitimleri, gebelerde farkındalık gibi bilgilendirmede ve evde yatağa bağımlı hastaların yakınlarına danışmanlık hizmeti gibi işlemlerde kullanımının daha uygun olacağı rapor olarak Halk Sağlığı Genel Müdürlüğü’ne sunulmuştur.
Reflections on fostering student nurse evidence-based practice competencies via integration of nursing best practice guidelines
Authors: Ewers Kathryn , Anyinam Charles , Davis Erin
Published: July 2022

Evidence-based nursing practice has been identified as an important nurse competency and standard of practice by nurse regulators and nurse educators in both the United States and Canada, yet little is known about the curricular strategies which foster development of evidence-based competencies in the undergraduate nursing context. Although there are several evidence-based practice models that are being used by nurses, much of the literature reflects evidence-based practice implementation strategies which are focused on nurses already in practice. It remains unclear how evidence-based practice competencies are being taught to undergraduate nursing students. In the Canadian context, the Registered Nurses’ Association of Ontario, promotes the implementation of Nursing Best Practice Guidelines as a viable strategy for implementing evidence-base nursing practice in both the clinical and academic contexts. Clinical and academic institutions that implement best practice guidelines and meet the outcome criteria of the Registered Nurses Association may be designated as a Best Practice Spotlight Organization. In this paper, two of the authors reflect on the curricular strategies they used to integrate Best Practice Guidelines into selected undergraduate nursing courses and the challenges and opportunities that this engendered as part of their university school of nursing’s journey to achieve designation as a Best Practice Spotlight Organization (Academic).
Ulica Nadrzeczna w Ciechanowie. Nazwy, ludzie i historia ogólna ulicy
Authors: Bielasta Barbara
Published: July 2022

Niniejsze opracowanie jest efektem zainteresowań autorki historią ciechanowskich ulic. Począwszy od ich powstania, pochodzenia i zmiany nazw, poprzez rozwój przestrzenny, a także prezentację rodzajów budowli stojących przy nich w różnych okresach historycznych (domy mieszkalne, obiekty użyteczności publicznej, zakłady przemysłowe). W historie ulic wpisują się też biogramy ciechanowskich mieszczan, w tym właścicieli poszczególnych parceli miejskich oraz informacje o innych ich użytkownikach.
„Zgasła w pierwszym rozkwicie młodości onegdaj w Zakopanym”. Przyczynek do poznania Zofii Krasińskiej (1873–1891)
Authors: Woźniak Beata
Published: July 2022

Wśród wielu opracowań dotyczących rodziny Krasińskich dominują, co zrozumiałe, opracowania poświęcone głównie Zygmuntowi Krasińskiemu – wybitnemu poecie, jednemu z polskich wieszczów narodowych. Ale interesujące mogą być również losy innych członków tej zasłużonej dla Polski rodziny. W szczególności tych, na których życiu odciskały swoje piętno skomplikowane uwarunkowania zdrowotne potomków Zygmunta Krasińskiego. Niniejszy artykuł poświęcony jest Zofi i Krasińskiej, jego wnuczce,która przez swoje krótkie życie zmagała się z dziedziczną w tej rodzinie chorobą – gruźlicą.
Study of mental health of medical staff in a specialized hospital for COVID-19 in Novi Sad
Authors: Kuljancic Dusan
Published: July 2022

Background and Objectives: The highly infectious novel coronavirus disease (COVID-19) emerged in Wuhan, China in late 2019 and soon became a global pandemic. COVID-19 is escalating medical staff psychological. In Novi Sad Clinical Centre of Vojvodina (CCV) for the past 2 years there has been a continuous struggle against the COVID-19 crisis. Both senior specialist doctors and newly hired young doctors, some without work experience, were hired immediately after completing their studies. Aim: To investigate the mental health of clinical first-line medical staff in COVID-19 epidemic. Methods: This is a cross-sectional study involving CCV staff who worked in the first line of patient treatment during the COVID-19 pandemic. They were given a self- administered questionnaire which included information on demographic and socio- economic characteristics and the validated DASS-21 and IES-R scale instrument. A total of 200 medical workers were involved. Results: Twenty-eight (14%) participants screened positive for depression, 49 (24,5%) for anxiety, 66 (33%) for stress, and 22 (11%) for clinical concern of PTSD. The most endangered are young nurses and doctors with less than 6 months of previous work experience. Conclusion: In conclusion, our results suggest frontline medical staff involved in treatment of COVID-19 patients should be closely monitored as a high-risk group for depression and anxiety, and given proper training before deployment.
Time gain compensation in orbital ultrasonography
Authors: Khazaei Dr. Hadi M , Seethapathy Dr. G
Published: July 2022

Time gain compensation (TGC) is a setting applied in diagnostic ultrasound imaging to account for tissue attenuation. By increasing the received signal intensity with depth, the artifacts in the uniformity of a B-mode image intensity are reduced. The purpose of TGC is to normalize the signal amplitude with time, compensating for depth. When the image is displayed, similar materials should have similar brightness, regardless of depth; this is achieved by “Linear-in-dB” Gain, which means the decibel gain is a linear function of the control voltage. Gain is expressed in dB, a logarithmic ratio of the output power relative to the input power. Gain can be calculated by subtracting the input from the output levels when both are expressed in dBm, which is power relative to 1 milliwatt. The TGC creates uniformity in the brightness of the echoes when used in conjunction with the overall gain. The best approach is to center all the TGC settings before adjusting the overall gain. After adjusting the overall gain, the TGC can then be adjusted to compensate for attenuation at specific depth. Gain is a uniform amplification of the ultrasonic signal that returns to the transducer after it travels through the tissue.
Terminologies and characteristics of natural mineral and thermal waters in selected European countries
Authors: ELSTER Daniel , SZŐCS Teodóra , GÁL Nóra , HANSEN Birgitte , D. VOUTCHKOVA Denitza , SCHULLEHNER Jörg , LIONS Julie , MARTARELLI Lucio , GIMÉNEZ-FORCADA Elena , DÍAZ-MUÑOZ José Ángel , MALCUIT Eline , SCHUBERT Gerhard , HOBIGER Gerhard , RMAN Nina
Published: July 2022

This study discusses 1) the national legislative frameworks, terminologies, and criteria for the recognition of natural mineral waters and thermal waters in selected European countries (Austria, Bosnia and Herzegovina, Denmark, France, Hungary, Iceland, Italy, Lithuania, Poland, Portugal, Romania, Serbia, Slovenia, and Spain), and 2) it provides a first extensive multi-national overview of hydrogeological and hydrogeochemical characteristics of numerous water sources from those regions. Natural mineral waters are well defined and regulated in the European Union by the Directives 2009/54/EC and 2003/40/EC that are implemented by national law regulations. In contrast, no legal definition exists for thermal waters on an EU level and national definitions commonly differ or are not present. Defining thermal waters by water temperatures of at least 20 °C at the outlet is commonly found (6 out of 15 countries), but other definitions like considering the difference to the average air temperature are also present. Furthermore, no definitions on a national level are quite frequent (5 out of 15 countries), those countries preferentially refer to expert recognitions. We considered 678 natural mineral waters and 2,390 thermal waters in this study and collected information on practical use, hydrogeological settings and hydrogeochemical conditions. The comparison of the datasets shows commonalities like a predominance porous aquifers, especially sandy aquifers, and sedimentary carbonate rock aquifers (limestone, dolomite, chalk). Furthermore, natural mineral waters commonly show TDS contents of less than 1 g/l and alkaline-earth-HCO3 water types. Surprisingly, 21 % of the considered sources bear water temperatures above 20 °C and could be considered as thermal waters as well. Thermal waters – the majority (above 30 °C) is found in Hungary - usually show water temperatures between 20 and 70 °C and TDS contents between 1 and 14.5 g/l. The hydrogeochemical properties show a larger variation in contrast to natural mineral waters, but Na-(HCO3, Cl) waters seem to be most commonly found.
Rare earth elements and yttrium in cold mineral and thermal (􀂽30-60 °C) waters from Tertiary aquifers in the Mura Basin, north-eastern Slovenia: A review
Authors: KRALJ Polona
Published: July 2022

bazenAbstractCold mineral and thermal waters from Tertiary aquifers in the Mura Basin mainly belong to the Ca-(Mg)-(Na)-HCO3 and Na-HCO3 hydrogeochemical facies, respectively, and the concentrations of yttrium (Y) and lanthanides or rare earth elements (REEs) are far below (10-2 – 10-4) the abundances in the aquifer sediments. Mineral waters are high pCO2, and the plots of concentrations of YREEs normalised to Post Archean Australian Shale (PAAS) show fractionation of Y and heavy REEs (HREEs) over light REEs (LREEs), and a significant positive europium (Eu) anomaly. Thermal water from regionally developed aquifer Thermal I (recently also termed the Mura/Ujfalu Formation aquifer) shows a similar PAAS-normalised pattern with an obvious positive Eu anomaly and the tendency of enrichment with middle REEs (MREEs). The plots of PAAS-normalised YREE concentrations in thermal waters from the underlying low-permeability aquifers with poorly developed fracture porosity and abundant CO2 are flat with insignificant positive Eu anomaly. The abundance and fractionation of YREEs in mineral and thermal waters seems to be mainly controlled by the presence of carbonate complexing ligands, permeability of the aquifers and the related time of water-rock interaction. YREEs have been used for geochemical recognition of overexploitation of the Sob-1 well that yields mixed waters from Thermal I and the underlying low-permeability aquifers. The well overexploitation has resulted in continuous 30-to-80-minute changes in hydrodynamic pressure in Thermal I, and the related change in temperature and chemical composition of abstracted water. Leakage from clayey-silty layers rich in coal and organic matter has been recognised over a several-year time scale by increased abundances of total organic carbon (TOC), YREEs, gallium (Ga), thallium (Tl) and selenium (Se). PAAS-normalised plots of YREE concentrations have shown significant positive anomalies of samarium (Sm), terbium (Tb) and holmium (Ho) and indicate the YHREE complexing ligands could be, beside carbonate species, humic and/or fulvic acids.
What is the prevalence of hepatic steatosis on ultrasonography in patients followed for nephrolithiasis?
Authors: Nguyen David-Dan , Bouhadana David , Wong Philip , Andonian Sero
Published: July 2022

Introduction: Patients with non-alcoholic fatty liver disease (NAFLD) have higher prevalence of nephrolithiasis. The aim of the present study was to determine prevalence of hepatic steatosis on ultrasonography in nephrolithiasis patients.
Methods: Charts of 318 consecutive nephrolithiasis patients seen in stone clinic between January and February 2018 were retrospectively reviewed. Ultrasound reports were reviewed for hepatic steatosis. Subsequent liver investigations were noted. Patients’ demographic predictors of hepatic steatosis were identified using univariable logistic regression models.
Results: A total of 162 patients was included, of which 76 (46.9%) were found to have hepatic steatosis and 22 (13.6%) were found to have moderate-to-severe hepatic steatosis. Median followup was 2.03 years. Predictors of hepatic steatosis included higher body mass index and smoking (both p<0.05). Progression of fatty liver on ultrasound was noted for 13 (17.1%) and regression was noted for two (2.6%). Of the 16 patients with a FIB-4 score, four (25.0%) patients required further investigation and 12 (75.0%) were unlikely to have advanced fibrosis. Of 12 patients who underwent fibroscan, one (8.3%) had both fibrosis and cirrhosis, two (16.7%) fibrosis only, and two (16.7%) moderate-to-severe steatosis.
Conclusions: Hepatic steatosis on ultrasound followup of nephrolithiasis patients is common, especially in smokers and overweight patients. Current recommendations suggest that primary care physicians calculate a FIB-4 score upon the detection of hepatic steatosis on ultrasound. The decision to refer to hepatology for a corroborative fibroscan is then based on the FIB-4 score.
Effect of Carbonization Temperature on Physical Properties and Specific Capacitance of Activated Carbon Derived from Banana Stem and Its Application as Supercapacitor Electrodes
Authors: Dulyaseree Paweena , Sama Hasanee , Sada Suraida , Ukkakimapan Pundita , Yordsri Visittapong , Sattayarut Vichuda , Wongwiriyapan Winadda
Published: July 2022

In this work, activated carbons (ACs) for electrodes supercapacitor applications were successfully synthesized from banana stem. Banana is one of the popular fruits that is easy to grow and most parts of the plant can be used. However, banana cultivation generates a lot of wastes, especially from the stem. Thus, using banana stem as raw material for ACs was investigated. The synthesis of AC consisted of 2 processes; carbonization and activation. The advantage of a two-step synthesis was the low weight loss of charcoal. Firstly, the carbonization process was conducted by varying the temperature between 300-600°C, and then inorganic elements were removed by treatment with 1 M sulfuric acid. After that, activation was conducted at 720°C under an argon atmosphere. The electrochemical properties of banana stem-derived ACs (BCH-ACs) were studied using sodium sulfate as an electrolyte. The BCH-ACs carbonized at 400C showed the highest performance with a specific capacitance of 55.45 Fg-1, an energy density of 7.70 Whkg-1 and a power density of 133.94 Wkg-1. The highest specific capacitance of the BCH400-AC was likely due to the increase in the amount of oxygenated functional group, which facilitated the access of electrolyte ions into the electrode. These results suggest that banana stem can be used to synthesize ACs via carbonization at 400C, and the ACs generated can be applied as electrode in supercapacitors.
«The Rules for Terakoya School Disciples» by Sasayama Baian (late 17th century): Japanese text and Russian translation
Authors: Lushchenko A. Yu.
Published: July 2022

The article contains a full Russian translation of «The Rules for Terakoya School Disciples» («Terako seikai shikimoku») written by the Osaka-based calligraphy teacher Sasayama Baian (late 17th century). This text was not only a list of school rules and moral teachings, but it also functioned as a model text to be copied by hand. It was republished many times in the 18th–19th centuries, gaining popularity as a text widely studied in terakoya schools. Japanese text and Russian translation presented in this article are based on the edition published in 1835. The work’s focus is not on handwriting techniques, but on the significance of mastering handwriting and on the proper behavior of disciples. The text’s author attaches great importance to the concept of the Human Way (hito no michi), that is rooted in Confucian ethics. Relationship between handwriting and human heart/mind (kokoro) figures prominently in this work. Its teachings cover various aspects of a disciple’s life: handling of writing utensils, interaction with teachers and classmates, diligence and concentration, etiquette, harmful habits, behavior in school and on the street. In general, this text clarifies what was approved and criticized in terakoya schools. This didactic text contains expressions written in the epistolary style (sōrōbun) that was used in letters and documents. The text is written in cursive style commonly used in the Edo period. This and other textbooks of the 17th–19th centuries can still be used for educational purposes. For example, it seems useful to read and copy them by hand following the practice of terakoya schools.
The influence of Fredric W. Brown’s micro fiction on Hoshi Shin’ichi’s and Akagawa Jirō’s short-short stories
Authors: Khronopulo L. Yu.
Published: July 2022

The short-short story was first introduced by Japanese writer Tsuzuki Michio, who in the late 1950s – the early 1960s familiarized the Japanese reader with extra-short stories of American author Fredric W. Brown (1906–1972); his traditions were followed by Japanese writer Hoshi Shin’ichi (1926–1997), Akagawa Jirō (b. 1948), and other authors experimenting in the new genre of social and psychological science fiction, as well as in the genre of fantasy and detective stories. In American literature, three major specific features of a short-short story were formulated: 1) a fresh idea, 2) an unexpected turn of events, 3) an unpredictable ending. These specific features can be traced in Japanese extra-short stories as well. Since the process of the emergence and development of the extra-short story as a new form of Japanese literature was influenced by American micro fiction, the research examines the elements borrowed from Fredric W. Brown’s micro fiction in Hoshi Shin’ichi’s and Akagawa Jirō’s first short-short stories; this includes genres, topics, canons, artistic styles and devices, as well as the treatment of certain social problems. The paper analyzes Hoshi’s and Akagawa’s short-short fiction from a comparative perspective, with an emphasis on intertextuality – shaping of a text’s meaning by another text, in this case, the texts by an American writer. Some literary parallels to Fredric W. Brown’s micro fiction can be found in Hoshi Shin’ichi’s first collection of short-short stories «Bokko-chan» (1971), which consists of stories written in 1958–1970, as well as in Akagawa Jirō’s first collection of short-short stories «The Dancing Man» (1986), which consists of stories written in the late 1970s – early 1980s. The succession of plots and philosophical ideas by Brown is examined on the material of seven early short-shorts by Hoshi, where the allusion to the American writer’s micro fiction can be traced; in addition, it is also noted that, in some mystic extra-short stories by Akagawa, it is not the plots which are borrowed, but mostly artistic devices and various techniques, such as psychologism, black humor, wordplay, and metaphorical images. American origins of the Japanese short-short story are investigated for the first time.
Retinopati Klorokuin dan Hidroksiklorokuin
Authors: Alberta Ivana Beatrice , Tri Ekaputri Maria Vania , Amita Angela Shinta Dewi
Published: July 2022

Klorokuin dan hidroksiklorokuin kerap digunakan sebagai tatalaksana berbagai penyakit autoimun, infeksi malaria, dan kini menjadi salah satu obat penanggulangan darurat Coronavirus Disease-19 (COVID-19). Kedua obat ini berpotensi sebagai antiinflamasi dan antivirus. Namun penggunaannya sering menimbulkan berbagai efek samping seperti pada jantung, saraf, saluran pencernaan, dan juga mata. Efek samping pada mata dapat berupa toksisitas retina yang dapat berakhir menjadi retinopati ireversibel. Guna menghindari cacat permanen, diperlukan pencegahan yang tepat dengan mengenali faktor risiko dan skrining, serta pemantauan ketat penggunaan obat.

Chloroquine and hydroxychloroquine are often used as a treatment for autoimmune disease, malaria infection, and now become an emergency drug for Coronavirus Disease-19 (COVID-19). Both are potential anti-inflammatory and antiviral agents. However, potential various side effects to the heart, nerves, gastrointestinal tract, and also eyes must be considered. Side effects on the eyes are retinal toxicity which can end up as irreversible retinopathy. Proper prevention is needed by recognizing risk factors and screening, as well as strict monitoring of drug use.
Perkembangan Diagnosis dan Tatalaksana Infeksi Mycoplasma genitalium
Authors: El Novita Sylviany
Published: July 2022

Mycoplasma genitalium adalah organisme penyebab infeksi menular seksual dengan prevalensi pada populasi risiko tinggi sekitar 10-41% pada laki - laki dan 7,3-14% pada perempuan. Mycoplasma genitalium menjadi penyebab sekitar 15-20% kasus uretritis non spesifik pada laki - laki dan 30% menyebabkan uretritis persisten atau rekuren. Infeksi M. genitalium dapat asimtomatik atau dengan gejala. Pada tahun 2019, US Food and Drug Administration menetapkan Aptima Mycoplasma genitalium Assay sebagai tes amplifikasi asam nukleat pertama yang diautorisasi untuk mendeteksi M. genitalium. Tes yang akurat dan spesifik berperan penting dalam pemilihan terapi, yang dapat membantu mengurangi penggunaan antibiotik berlebihan dan membantu melawan resistensi antibiotik.

Mycoplasma genitalium is a sexually transmited bacterium with 10-41% prevalence in men and 7,3-14% in women in the high risk population. Mycoplasma genitalium is responsible for 15-20% non specific urethritis in men and cause of 30% persistent or recurrent urethritis. Aptima Mycoplasma genitalium Assay is the first FDA authorized nucleic acid amplification test to detect M.genitalium. Accurate and reliable tests to identify specific bacteria can lead to the appropriate treatment, reduce antibiotics overuse and antimicrobial resistance.
Kejang Demam sebagai Faktor Predisposisi Epilepsi pada Anak
Authors: Hasibuan Dede Khairina , Dimyati Yazid
Published: July 2022

Kejang demam adalah bangkitan kejang pada anak berumur 6 bulan sampai 5 tahun yang mengalami kenaikan suhu tubuh (di atas 38°C dengan metode pengukuran suhu apapun) yang tidak disebabkan oleh proses intrakranial. Faktor-faktor risiko kejang demam berkembang menjadi epilepsi adalah kelainan neurologis atau perkembangan yang jelas sebelum kejang demam pertama, kejang demam kompleks (KDK), riwayat epilepsi pada orangtua atau saudara kandung, dan kejang demam sederhana (KDS) berulang 4 episode atau lebih dalam satu tahun. Kombinasi faktor risiko tersebut akan lebih meningkatkan risiko epilepsi. Pemberian obat rumatan kejang demam belum terbukti dapat mencegah epilepsi di kemudian hari.

Febrile seizure is a seizure episode in children aged 6 months to 5 years preceded with an increase in body temperature (above 38° C with any measurement method) not caused by intracranial process. Risk factors to epilepsy are neurological or developmental abnormalities before the first febrile seizure, complex febrile seizures, history of epilepsy in parents or siblings, and simple febrile seizures 4 episodes or more in one year. Combination of these risk factors will increase the likelihood of epilepsy. Febrile seizure prophylaxis medication has not been proven to prevent epilepsy.
Gambaran Klinis dan Patologi Melanoma Maligna Kutaneus
Authors: Chandra Rudi
Published: July 2022

Melanoma maligna (MM) merupakan keganasan sel-sel melanosit terutama di kulit. Paling sering didiagnosis pada pada wanita < 40 tahun, dan pada pria > 40 tahun. Predileksi MM tersering pada kulit punggung (pria) dan pada ekstremitas bawah (wanita). Secara klinis dan patologis, melanoma maligna diklasifikasikan sebagai superﬁcial spreading melanoma, nodular melanoma, lentigo maligna melanoma, acral lentiginous melanoma, dan varian lain yang jarang.

Malignant melanoma (MM) is melanocyte cells malignancy located mainly in the skin; most often diagnosed in women <40 years, and in men >40 years. MM predilection is in the back (men) and in lower extremities (women). Clinically and pathologically, malignant melanoma is classified as superficial spreading melanoma, nodular melanoma, malignant lentigo melanoma, acral lentiginous melanoma, and other rare variants.
Uremic Frost - Kelainan Kulit pada Gagal Ginjal Kronis
Authors: - Nathasia , Wijayadi Linda Julianti
Published: July 2022

Uremic frost merupakan kelainan kulit yang jarang, karena ditemukan pada pasien gagal ginjal kronik yang belum menjalani hemodialisis. Kelainan ini ditandai dengan lapisan putih kekuningan akibat kristal urea yang mengendap di permukaan kulit. Seorang wanita 44 tahun datang dengan keluhan utama kulit kering, bersisik, dan gatal seluruh tubuh sejak 1 bulan. Pasien baru didiagnosis gagal ginjal kronis. Pada pemeriksaan dermatologi didapatkan makula hiperpigmentasi, berbatas tegas, multipel, ukuran lentikular-plakat dan krusta putih kekuningan. Tatalaksana dermatologi uremic frost adalah dengan pelembap dan antihistamin oral, pengobatan lebih lanjut untuk penyakit ginjal penyakit ginjal yang mendasari.

Uremic frost is a rare skin disorder, found in chronic kidney failure patients who have not undergone hemodialysis. This disorder is characterized by yellowish white layer on the skin surface due to urea crystals. A 44-year-old female patient presented with dry, scaly, and itchy skin on the whole body in the last 1 month. The patient has just been diagnosed with chronic kidney failure. Dermatological examination revealed hyperpigmented macules, well-defined, multiple, lenticular-placard size and also a yellowish-white crust. Management in dermatology is with moisturizers and oral antihistamines, further treatment should be given to underlying kidney disease.
Peran Ultrasonografi Toraks pada Kasus Kegawatdaruratan Paru
Authors: Purnomo Wahyu Agung
Published: July 2022

Dahulu USG terbatas hanya untuk mengevaluasi masa atau efusi pleura. Namun dalam perkembangannya USG toraks ternyata mampu mendiagnosis pneumonia, Penyakit Paru Obstruktif Kronis (PPOK) atau asma eksaserbasi ; juga edema paru, tromboemboli paru, pneumotoraks, serta efusi pleura maupun empyema. Beberapa protokol dikembangkan untuk membantu mempermudah diagnosis kasus kegawat daruratan kardiorespirasi Tinjauan pustaka ini membahas peran ultrasonografi toraks pada kasus kegawat darutan paru agar dapat digunakan sebagai referensi di instalasi rawat darurat.

Previously, ultrasound use was limited to evaluate mass or pleural effusion. But in its development thoracic ultrasound was able to diagnose pneumonia, Chronic Obstructive Pulmonary Disease (COPD) or exacerbation asthma, pulmonary edema, pulmonary thromboembolism, pneumothorax, as well as pleural effusion and empyema. Several protocols were developed to help simplify the diagnosis of emergency cases of cardiorespiratory emergencies. This literature review will discuss the role of thoracic ultrasonography in cases of pulmonary emergency to be used in emergency settings.
Hiperkoagulabilitas pada Kehamilan dengan COVID-19
Authors: Marpaung Richardo , Chandra Evelyne , Suwanto Denny
Published: July 2022

Pandemi coronavirus disease 2019 (COVID-19) akibat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) menginfeksi lebih dari 7 juta jiwa di seluruh dunia dengan angka kematian lebih dari 400.000 jiwa. Koagulopati adalah salah satu sekuele paling berat dari COVID-19. Hipotesis terkait koagulopati ini melibatkan peningkatan signifikan respon inflamasi yang mengakibatkan trombo-inflamasi melalui mekanisme seperti badai sitokin, aktivasi komplemen, dan endotelitis. Dalam kehamilan, terdapat beberapa perubahan fisiologis yang memengaruhi koagulasi dan sistem fibrinolisis mengakibatkan kondisi hiperkoagulabilitas dan meningkatkan risiko kejadian tromboemboli. Tulisan ini memaparkan mekanisme hiperkoagulasi dalam COVID-19 dan kehamilan, manifestasi klinis, pemeriksaan laboratorium yang diperlukan, serta rekomendasi terapi.

Coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects more than 7 million people worldwide with a death toll of more than 400,000. Coagulopathy is one of the most severe sequelae of COVID-19. This coagulopathy-related hypothesis involves a significant increase in the inflammatory response that causes thrombo-inflammation , through several mechanism such as cytokine storms, complement activation, and endothelitis. In pregnancy, several physiological changes affect coagulation and fibrinolysis system which results in hypercoagulability and increases the risk of thromboembolic events. This article describes the mechanism of hypercoagulation in COVID-19 and pregnancy, clinical manifestations, necessary laboratory tests, and recommendations for therapy.

 
Fase Krisis Blast Chronic Myeloid Leukemia dengan Acute Renal Failure
Authors: Wibianto Anastasia , Prihadi Dinny Gustina
Published: July 2022

Leukemia myeloid kronik merupakan penyakit mieloproliferatif dengan komplikasi tersering gagal ginjal. Fase krisis blast cukup jarang tetapi terberat dari seluruh fase leukemia myeloid kronik dengan risiko kematian tertinggi. Kasus: Perempuan 72 tahun dengan leukositosis 218.700/µl dan gagal ginjal akut dengan kreatinin 7,1 mg/dL. Dari morfologi darah tepi disimpulkan leukemia mieloid kronik dengan sel blast 54%. Pasien diterapi dengan dua sesi leukapheresis, dan idarubicin selama 3 hari dengan terapi pengganti ginjal berkelanjutan. Selanjutnya pasien diberi sitarabin IV selama 7 hari, dengan hasil remisi.

Chronic myeloid leukemia is a myeloproliferative disease with renal failure as the most common complication. Blast crisis is the rarest but worst phase of chronic myeloid leukemia with highest mortality. Case: A 72-year-old woman presented with leukocytosis 218,700/µl, and acute renal failure with creatinine 7,1 mg/dL. The peripheral blood morphology showed chronic myeloid leukemia with 54% blast cells. The patient was treated with two sessions of leukapheresis, and idarubicinfor 3 days in the setting of continuous renal replacement therapy, followed with 7 days of continuous cytarabineinfusion. The patient went into a complete remission.
Penggunaan Hydroxychloroquine dalam Tatalaksana Covid-19
Authors: Kristiningrum Esther
Published: July 2022

Penyakit coronavirus 2019 (Covid-19) telah menyebar dengan cepat ke seluruh dunia. Saat ini berbagai obat telah diteliti dalam upaya mengobati dan mencegah penularan virus tersebut, salah satunya adalah hydroxychloroquine yang selama ini dikenal sebagai obat antimalaria dan obat penyakit autoimun seperti lupus eritemasosus sistemik. Selain efek imunomodulasi, studi in vitro menunjukkan bahwa hydroxychloroquine juga memiliki efek antivirus, namun studi pada pasien Covid-19 hasilnya bervariasi dalam hal perbaikan outcome. Saat ini pada kondisi pandemi, hydroxychloroquine secara darurat bisa digunakan terbatas dalam pengawasan ketat oleh dokter untuk pengobatan pasien Covid-19 dewasa dan remaja yang memiliki berat badan 50 kg atau lebih dan dirawat di rumah sakit.

The 2019 coronavirus disease (Covid-19) has spread rapidly throughout the world. Various drugs have been studied for treating and preventing virus transmission, including hydroxychloroquine, known as antimalarial and an autoimmune disease drug such as systemic lupus erythematosus. In addition to an immunomodulating effect, in vitro studies have shown that hydroxychloroquine also has antiviral effects, but studies on Covid-19 patients have shown mixed results. Currently, in pandemic conditions, hydroxychloroquine can be limitedly used for emergency under close medical supervision for treating adults and adolescents weighed 50 kg or more with Covid-19 in a hospital setting.
Best Vitelliform Dystrophy
Authors: Wisesaputra Tjok Agung Purnama
Published: July 2022

Best Vitelliform Dystrophy or Best disease is an autosomal dominant maculopathy caused by mutations in the BEST1 (or VMD2), which is located on chromosome 11 and encodes the protein bestrophin, this protein localizes to the basolateral plasma membrane of the RPE. Affected individuals frequently show a yellow macular lesion, like egg yolks. This disease tends to present in children or young adults. Until now there has been no treatment for Best disease.

Best Vitelliform Dystrophy atau Best disease autosomal dominant maculopathy disebabkan oleh mutasi gen BEST1 (atau VMD2), yang terletak pada kromosom 11 dan mengkodekan protein bestrophin, protein ini terlokalisir pada membran plasma basolateral RPE. Individu Best disease sering menunjukkan lesi makula berwarna kuning, seperti kuning telur. Penyakit ini cenderung muncul pada periode anak-anak atau dewasa muda, Sampai saat ini belum ada pengobatan untuk Best disease.