bluuebunny/crossref_metadata_2025 huggingface dataset:
Musimy porozmawiać o macierzyństwie – o przełamywaniu tabu trudnego macierzyństwa we współczesnym kinie
Authors: Garncarek Emilia
Published: January 2023

Artykuł jest próbą ukazania „kinowych odzwierciedleń” współczesnego trudnego macierzyństwa, które w ostatnim czasie jest coraz częściej zauważane i przedstawiane przez zachodnią kinematografię. Autorka tekstu poszukuje odpowiedzi na pytanie – jak wybrane obrazy filmowe naruszają i dekonstruują patriarchalny porządek płci w odniesieniu do macierzyństwa? Tekst prezentuje wyniki jakościowej analizy wybranych obrazów filmowych: Musimy porozmawiać o Kevinie (2011), Córka (2021). Podstawę teoretyczną zrealizowanych badań stanowiły: podejście genderowe w badaniach społecznych oraz koncepcja winy i wstydu T. Scheffa.
O początkach greckiego dramatu satyrowego
Authors: Zalewska-Jura Hanna
Published: January 2023

In disputatione opinio ad origines fabularum satyricarum pertinens, quae contra sententias doctissimorum virum resistit, continetur.
Czy komedie Arystofanesa nadal wzbudzają śmiech?
Authors: Komornicka Anna Maria
Published: January 2023

Pour tenter de deceler la source intarissable de la vitalite comique d'Aristophane, il a fallu prendre en consideration une multiplicite aspects.
Aulos w komedii antycznej
Authors: Maciejewska Anna
Published: January 2023

In hoc articulo monstrantur testimonia comoediarum antiquarum ad tibiam ipsam, tibicines tibicinasque pertinentia.
Inspiracje antyczne w "Odprawie posłów greckich" Jana Kochanowskiego. Rekonesans badawczy
Authors: Wichowa Maria
Published: January 2023

Paper presents research on the first Polish Renaissance tragedy by Jan Kochanowski "Odprawa posłów greckich".
Evolution over Time of the Effects of Fiscal Shocks in the Peruvian Economy: Empirical Application Using TVP-VAR-SV Models
Authors: Rodríguez Gabriel , Meléndez Holguín Alexander
Published: January 2023

Esta investigación evalúa el impacto y la evolución de la política fiscal sobre la actividad económica peruana en el periodo 1993Q4-2018Q2 usando modelos TVP-VAR-SV irrestrictos y restrictos siguiendo el enfoque de Chan y Eisenstat (2018a). Los resultados señalan que la inclusión de volatilidad estocástica es indispensable y que no hay una clara evidencia de parámetros cambiantes según dos criterios de selección bayesianos. Los choques del crecimiento del gasto corriente y del crecimiento del gasto de capital impactan positivamente sobre el crecimiento del PBI (0.2% y 0.3%, respectivamente, ante un incremento de 1% de cada variable), y son importantes en la descomposición de la varianza del error de predicción (23% y 45%, respectivamente) y en la descomposición histórica del mismo (14% y 25%, respectivamente). El impacto de los choques del crecimiento de los ingresos fiscales es débil en todo el periodo de estudio. Los multiplicadores de gasto corriente y de gasto de capital se incrementan entre 1995Q1-2007Q4, pero luego muestran valores menores entre 2008Q1-2018Q2. Adicionalmente, se encuentra que los choques externos tienen un impacto fuerte y positivo sobre el crecimiento de los ingresos fiscales (0.4%). Por último, se realizan diferentes ejercicios de robustez en los que se observan pocos cambios respecto a los resultados obtenidos en el modelo baseline.
Quality Characteristics and Sensory Attributes of Dough and Bread Fortified by Carob, Malt and Soybean Flours
Authors: Hariri A. , Ouis N. , Bouhadi D. , Benattouche Z.
Published: January 2023

Background: The objective of this study was to evaluate the effect of the partial replacement of wheat flour by carob, malt and soybean flours on the characteristics of dough’s and breads. Methods: For preparation of basic dough, wheat flour was blended with water, sodium chloride and dried yeast. The samples were subjected to the operations of mixing, proofing and baking. The carob, soybean and malt flours were used in increasing ratio 1-5%. Result: Physicochemical properties of composite flours showed that the proteins level (for soybean), ash, fat, fatty acids and starch were increased with increase level of flours substitution. Composite flours prepared with carob and soybean displayed higher amounts of dry and wet gluten, Zeleny number and lower value of failing number. For sensory characteristics, carob and soybean breads received higher liking scores compared to the malt and wheat samples. For malt, only 1% was able to improve the color, section shapes and texture of bread. This study demonstrated the potential use of carob, soybean and malt flours to improve the overall characteristics of the dough’s and breads.
On Student Psychology, Patriotism, and Love for the Fatherland
Authors: Zhukov Vadim N.
Published: January 2023

The article explains the necessity of treating patriotism from the point of view of its scientific evaluation. Some peculiarities of student psychology and their influence on the perception of the idea of patriotism are considered.
Participación de padres varones en jardines infantiles privados chilenos: condiciones de posibilidad percibidas
Authors: Campillay Figueroa Francisca Pía , Gubbins Foxley Verónica
Published: January 2023

Existe consenso entre investigadores, que la participación de padres varones en la educación parvularia optimiza el desarrollo infanto-juvenil. Sin embargo, en la práctica esta participación es baja si se la compara con la de las mujeres. Este artículo expone los resultados de una investigación cualitativa cuyo objetivo es el de explorar la percepción que, padres varones con hijos e hijas que asisten a centros educativos privados chilenos, tienen sobre las condiciones que posibilitan o no su participación en el centro educativo. Se utilizan 8 entrevistas semiestructuradas. El artículo devela disposiciones a participar que se ven coaccionadas por factores culturales, estructurales e institucionales. Las condiciones de posibilidad se privatizan y dependen de la capacidad de negociar acuerdos entre figuras parentales. Este estudio aporta a la comprensión de las condiciones que afectan la participación de los padres varones en la educación inicial. Se discuten implicancias para las políticas de participación parental y el trabajo de las instituciones educativas.
Bienestar psicológico en estudiantes de primeros ciclos de una universidad privada de Lima
Authors: Rodríguez Flores Eduar Antonio , Sánchez Trujillo María de los Ángeles
Published: January 2023

La modalidad educativa a distancia, sumada a las exigencias propias del ámbito universitario, puede generar estados de ansiedad e incertidumbre en los estudiantes. Frente a ello, se realizó una investigación cuyo objetivo fue describir el bienestar psicológico de los estudiantes universitarios de primeros ciclos. Este es un estudio de caso descriptivo, con un enfoque cualitativo y diseño fenomenológico. La investigación se efectuó entre marzo y agosto de 2021, y estuvo dirigido a 20 estudiantes y 10 docentes de la Facultad de Ciencias de la Salud de una universidad privada de Lima. Para la recolección de datos, se aplicaron una guía de grupo focal dirigida a los docentes y una guía de entrevista semiestructurada dirigida a los estudiantes. Entre los hallazgos, destaca el reconocimiento de seis categorías centrales interrelacionadas: autoaceptación, propósito en la vida, autonomía, dominio del entorno, relaciones positivas y crecimiento personal. En términos generales, se evidenció el estado favorable de bienestar psicológico de los estudiantes, relacionado con un clima positivo del aula, así como una autopercepción favorable. No obstante, se identificaron ciertas debilidades, tales como la incapacidad de asumir la responsabilidad de sus propios actos, y la carencia de metas a corto, mediano y largo plazo. En conclusión, los resultados han permitido describir el bienestar psicológico del alumnado que formó parte de la muestra de estudio, lo cual ha posibilitado identificar las fortalezas y oportunidades de mejora que se debe tomar en cuenta para futuros estudios, así como el diseño de propuestas orientadas a mejorar la situación problemática.
Evaluation of improved plantain type of banana (Musa spp.) varieties at Mechara on Station, Eastern Ethiopia
Authors: Assefa Gezahegn , Girma Sintayehu , Deressa Dereje
Published: January 2023

Fruit crops are widely grown in west Hararghe by small households and plays significant role for income generation and nutrition. Plantains are cooking type’s banana producing fruits that remain starchy at maturity and need processing before consumption. Even though the environment is suitable for the production of fruit, the productivity of the crop is highly influenced by low yielding variety and low moisture. Therefore, the trail was conducted to evaluate high yielding, drought and disease resistant/tolerant Plantain types of Banana varieties at Mechara onstation. Four plantain varieties were brought from Melkasa Agricultural Research Center and evaluated for agronomic and yield and yield related traits using Completely Randomized Block Design in three replications. The Analysis of variance results revealed significant variation among plantain varieties for all traits over both harvesting cycles except Fruit diameter (cm), number of fruit per bunch and unmarketable yield. The highest bunch weight, number of hands per bunch, number of fruits per bunch, marketable yield and total yields had recorded from Nijiru variety followed by kardaba. Nijiru variety was resistance to banana disease (sigatoka and panama disease) as compared to the other varieties. Whereas the lowest bunch weight, number of fruits per bunch, marketable yield, total yields was observed from Matokke variety. The Pearson correlation coefficient showed that average bunch weight, Fruit diameter, number of finger per hand and Marketable yield were positively correlated to total yield. It is, therefore, concluded that Nijiru variety was well performed and can be recommended for the growers for Mechara and similar agro ecology of the area.
Characterization of Phytoplasmas associated with cassava (Manihot esculenta Crantz) infection in Southern and Southeastern Côte d'Ivoire
Authors: Kouame Christine Ahou , Kra Daniel Kouamé , Toualy YeyehMarie Noël , Diallo Hortense Atta , Bi Arsène Irié Zoro
Published: January 2023

In Côte d'Ivoire, cassava is an important source of food and income for the population. However, its development is confronted with the attack of numerous pathogens such as phytoplasmas as observed in several countries in recent years. The main aim of this study is to diagnose cassava leaf infection in Côte d'Ivoire in order to contribute to sustainable production. Thus, cassava leaf samples were collected from nine growing localities. Molecular analyses required the use of the universal primer pairs for the direct PCR and specific primers for Nested PCR in order to detect the presence of phytoplasmas in the DNA extracted from the samples. Mosaic, vein banding, chlorosis, shoestring and witches' broom symptoms were observed, sometimes alone and other times in complex symptoms. The prevalence of leaf infections was over 70%, with average severity scores ranging from 4.29 to 4.74 depending on the cassava variety. Of the samples tested, 42 (19.44%) were positive with the specific primer (AkwaSR/GH813f) and 32 (18.39%) with the universal primer (R16mF2n/R16mR2), thus demonstrating the presence of phytoplasmas in both symptomatic and non-symptomatic cassava leaves. The amplicons obtained with the specific primer pair allowed the detection of the phytoplasma "Candidatus Phytoplasma palmicola" of subgroup XXII-B associated with the coconut lethal yellowing disease in Côte d'Ivoire in cassava grown in the different collection localities.
On deoxidation and modification of carbon steel
Authors: Marukovich E. I. , Stetsenko V. Yu. , Stetsenko A. V.
Published: January 2023

It has been shown that the elementary crystal cells of the basic products of deoxidation and modification of carbon steel, δ ferrite and austenite do not correspond to the principle of structural and dimensional correspondence of Dankov – Konobeevsky. Modifying elements Ba, Ca, Mg, Ce, Al increase the surface energy of the iron‑carbonaceous melt by binding surface active oxygen. Deoxidizers combine dissolved (free) oxygen into oxides, and modifiers – adsorbed oxygen. Steel modification is a nanostructural process in which modifying elements refine elemental iron nanocrystals from adsorbed oxygen and hydrogen atoms. Modifying elements reduce the concentration of dissolved hydrogen, which contributes to the modifying effect. The strongest deoxidizer and modifier of carbon steel is magnesium.
Concept for development of economically alloyed ausferritic (bainitic) ductile cast irons
Authors: Pokrovsky A. I.
Published: January 2023

The distribution of the castings production in the world, whose total output is more than 112 million tons, is considered. A steady trend to the replacement of rolled alloy steel, which is used for critical engineering products, by Austempered Ductile Iron (ADI) is outlined. The latter is ductile cast iron with globular graphite, which is austempered (isothermally quenched) to produce ausferritic (bainitic) structure. The dynamics of prices for main alloying elements in ADI (molybdenum, nickel and copper, whose total amount in the alloy reaches 5 %) is considered and their steady growth is outlined.

The research goal is to develop a concept of economical alloying of ADI (the total content of Mo, Ni and Cu should not exceed 2 %) retaining sufficient hardenability and substantially decreasing the cost price. The goal is attained by decreasing the content of the most expensive alloying element, molybdenum, to a minimal level along with the use of microalloying and applying one of the methods of hot plastic deformation to the casting.

The reduced content of the main ‘triad’ of alloying elements is compensated by microadditives of strontium or barium, vanadium, boron, niobium and the addition of misch metal. Several groups of economically alloyed cast irons are proposed: (1) low‑nickel and low‑molybdenum with increased content of copper (up to 1.8 %) and the addition of vanadium, (2) molybdenum‑free with microadditive of boron, (3) molybdenum‑free with microadditives of niobium and boron, and (4) molybdenum‑free minimally alloyed with nickel and copper.

It is shown that plastic deformation, along with giving the product the required shape, affects the kinetics of structural‑phase transformations. and acts similarly to alloying with Mo and Ni, shifting the TTT‑curve to the right. Therefore, the ausferritic structure can be obtained at a lower cooling rate.

The mechanical properties with such alloying and the use of plastic deformation are the following: ultimate tensile strength 1100–1500 MPa and elongation to failure 2–4 % for lower bainite; ultimate tensile strength 800–1100 MPa and elongation to failure is 4–7 % for upper bainite.
On modification of silumins
Authors: Marukovich E. I. , Stetsenko V. .Yu. , Stetsenko A. V.
Published: January 2023

It has been shown that the elementary crystal cells of the basic products of modification of silumins, aluminum and silicon do not correspond to the principle of structural and dimensional correspondence of Dankov – Konobeevsky. Modifying elements B, Sr, P significantly increase the surface energy of liquid silumins, and Zr and Ti practically do not affect it. Modification of silumins is a nanostructured process. Ti, Zr, B form intermetallides that refine aluminum nanocrystals from demodifying adsorbed hydrogen atoms. Phosphorus, atomically dissolving in silumin, refiners silicon nanocrystals from adsorbed oxygen. Na and Sr form an emulsion and colloid in liquid silumin, which protect eutectic microcrystals of α‑and βSi‑phases from demodifying molecular hydrogen. All these processes increase the concentration of crystallization centers of dendritic microcrystals α‑and βSi‑phase, make them more branched and compact.
The effect of Etanercept therapy on adrenal steroid metabolism in juvenile idiopathic arthritis: a steroid metabolomics approach
Authors: Aviel Yonatan Butbul , Keinan Ariel , Hartmann Michaela F. , Wudy Stefan A. , Tiosano Dov
Published: January 2023

Objective: To evaluate the impact of anti-tumor necrosis factor-alpha (TNFα: etanercept [Etanercept ®]) therapy on adrenal activity in juvenile idiopathic arthritis (JIA) .
Method: Eleven JIA patients aged 12±6.2 years with a disease duration of 6.3±5.2 years were enrolled. They were treated once weekly with etanercept (0.8 mg/kg) for 3±2.8 years. Urine samples for gas chromatography-mass spectrometry steroid hormone analysis were collected before, and 1 and 3 days after etanercept injection and compared to age- and sex-matched healthy controls.
Results: The levels of 21 of the 31 metabolites were low before etanercept treatment. Those 21 metabolites included 4 C19 steroids (androgens), 5 C C21 steroid hormone intermediates, 10 cortisol metabolites, and 2 corticosterone metabolites. One day after treatment, only 5 of the 21 metabolite levels remained low. They included 2 C19 metabolites, 2 C21 steroid metabolites and 1 cortisol metabolite β –Cortol (β-Cl). Three days after treatment, the only metabolites levels that continued to be low were 2 C19 metabolite, 2 C21 steroid hormone intermediates and 1 cortisol metabolite α-Cortol (a-Cl), while the remaining 15 metabolites had already normalized after 1 day. Dehydroepiandrosterone-sulfate and 17-hydroxypregnenolone metabolite levels were the last ones to recover. Urinary metabolite ratios reflecting cytochrome P450 CYP21A2 (21-hydroxylase) and 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) enzymatic activities were lower in JIA patients than in controls, although significant was not reached.
Conclusion: Almost all of the pre-etanercept treatment cortisol urinary metabolite levels were significantly lower than normal, and almost all rose to normal values by 1 day after treatment. The therapeutic effect of anti-TNFα treatment in JIA may be related to its effect on the restoration of adrenal function and cortisol levels.
Mathematical Model for the Quantification of Pulmonary and Intrapulmonary Arteriovenous Anastomoses Blood Flow
Authors: Vanni Rosalba
Published: January 2023

Background and Objectives: Accurately quantifying blood flow through a shunt vessel is vitally important, because shunt prevents gas exchange and can provide a pathway for emboli to bypass the pulmonary microcirculation. Some current techniques allow only an approximate estimate of the pulmonary shunt and present technical-evaluation difficulties that can compromise the result.
To overcome the technical-evaluation problems and obtain an accurate detection of the pulmonary blood flow
(Qp) and intrapulmonary arteriovenous anastomoses (QIPAVA), it is necessary to find and isolate the fundamental parameters of gas exchange associated with chemical-physical laws that regulate them, develop a specific algebraic-analytical model and subsequently validate it by entering some experimental data.
Methods: Elaboration of nine literal equations designed similarly to physics formulas of universal application. Some experimental data were entered to validate them.
Results: Qp and QIPAVA were detected at rest, moderate (50% of VO2max) and heavy exercise (≥90% of VO2max)
both in normoxia (FIO2= 0.2093) and acute hypoxia (FIO2= 0.125).
In normoxia under heavy exercise, Qp decreased slightly (97.56% of Qt), and QIPAVA represented 2.44% of Qt.
Instead, in hypoxia at heavy exercise, Qp decreased significantly (85.25% of Qt), and QIPAVA increased significantly (14.75% of Qt).
It was possible to demonstrate a negative contribution of QIPAVA directly to gas exchange efficiency and identify incorrect Qt measurements.
Conclusions: These equations are precise and of universal application. They describe the real phenomenon of gas exchange for each individual.
Qp differs significantly from Qt under some physiological conditions already in healthy subjects.
The use of this model will allow research a general advance in the understanding of this critical biological function and in clinical practice a precise and early detection of the pathology.
Stillbirth and Its Association with Early rupture of Membranes in Sub-Saharan Africa: Systematic Review and Meta-Analysis
Authors: Yezengaw Telksew Yelma , Dingeta Tariku , Assebe Tesfaye , Tusa Biruk Shalmeno
Published: January 2023

Background
Stillbirth rate is an important indicator of access to quality antenatal and delivery care services. Many previous pocket studies were conducted to assess the magnitude of stillbirth and its association with premature rupture of membrane. However, the level of stillbirth, as well as its relationship with premature rupture of membrane (PROM), varies from study to study. This systematic review and meta-analysis was conducted to estimate the pooled prevalence of stillbirth and its association with the early rupture of membranes in sub-Saharan Africa.
Method
Electronic databases such as PubMed Central PMC, Cochrane library, Medline via Virtual Health Library (VHL), HINARI (Health Inter Network Access to Research Initiative) portal, and Google scholar were used for searching for original articles. The heterogeneity of the studies was checked by I-squared statistics. A Random-effects method was applied to estimate the pooled prevalence of stillbirth and the effect size of the early rupture of membranes in sub-Saharan Africa. Subgroup analysis was performed based on region (East, West, Central, and Southern Africa) and year of study (before 2015 and after 2015). A funnel plot and Egger’s regression test was used to see publication bias.
Result
Pooled prevalence of stillbirth in sub-Saharan Africa was 6.4% (95% CI: 5.5–7.3). In sub-group analysis, Southern African regions had a higher stillbirth prevalence and the western African regions had a lower than East and Southern Africa. The prevalence of stillbirth in the region is increased from 4.1% (95% CI: 2.2–6.0) before 2015 to 7.1% (95% CI: 5.8–8.3) after 2015. The pooled odds ratio results from seven studies showed the non-significant effect of early rupture of membrane on stillbirth (pooled OR = 1.54, 95% CI: 0.26–2.82). According to the regression test (Egger test), there was no small study effects or publication bias (P = 0.108).
Conclusions
The pooled prevalence of stillbirth in sub-Saharan Africa was relativity high. The analysis establishes the minimal effects of early rupture of membrane on stillbirth. Therefore, we recommend that strengthening the testing intervention is crucial to reduce the still relatively high stillbirths.
Upper body compression wear improves muscle oxygenation following intense video game training: a randomized cross-over study among competitive gamers
Authors: DiFrancisco-Donoghue Joanne , Rothstein Alexander , Jung Min-Kyung , Zwibel Hallie , Werner William G
Published: January 2023

Esport players require a high number of action moves per minute to play with substantial contractions of the wrist extensor muscles. Players frequently suffer from acute fatigue. The purpose of this study was to examine the use of below the elbow compression sleeves on Sm02 during intense aim training. Secondly, to examine players’ performance and perception with and without compression. Methods This study was conducted at the New York Institute of Technology and enrolled fifteen collegiate esport players, 2 women and 13 men (age 21.2 ± 2.2). All subjects signed written consent. Participants performed 3 high intensity bouts of an aim trainer followed by a 15-minute rest before doing another 3 bouts of high intensity training conducting the other arm. The compression wear order was randomized. The primary outcome included Sm02 of the extensor carpi radialis longus using near-infrared spectrometry. Secondary outcomes included Kills Per Second (KPS), Score, Total Time to Kill (TTK), accuracy, and perceived performance. Results Following 15 minutes of recovery, there was a significant rise in Sm02 while wearing the compression sleeve compared to no compression sleeve (p = 0.004). No change in Sm02 was seen while gaming. In trials 1 and 2, wearing the compression sleeve resulted in a significant increase in KPS and score when compared to not wearing it (p = 0.002,0.006). Although TTK and accuracy did not alter, 46.7% of participants believed the compression sleeve aided their performance. Conclusions This study provides support that wearing below the elbow upper body compression sleeves while performing high intensity gaming may reduce fatigue, improve muscle recovery and gaming performance. Trial registration: Clinicaltrials.gov identifier NCT05037071. Registered September 8, 2021, URL: Arm Compression on Muscle Oxygen Saturation - Full Text View - ClinicalTrials.gov
Blood-brain barrier disruption in Long COVID-associated cognitive impairment
Authors: Greene Chris , Connolly Ruairi , Brennan Declan , Laffan Aoife , O'Keeffe Eoin , Zaporojan Lilia , Connolly Emma , Cheallaigh Cliona Ni , Conlon Niall , Doherty Colin , Campbell Matthew
Published: January 2023

Vascular disruption has been heavily implicated in COVID-19 pathogenesis and may predispose the neurological sequelae associated with the condition now known as long COVID. To date, no studies have objectively assessed blood-brain barrier (BBB) function in individuals with neurological complications stemming from prior SARS-CoV-2 infection. Here, we explored the neurobiological effects of SARS-CoV-2 infection in humans with acute infection (n = 76) and those with persistent long COVID with and without neurological impairment. Following acute infection, patients with neurological impairment had increased serum S100β, indicative of BBB disruption. Furthermore, using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in long COVID patients (n = 32), we observed elevated BBB permeability in distinct neuroanatomical regions including the frontal cortex, occipital lobe and temporal lobes which correlated with global brain volume and white matter volume deficits in patients with neurological impairment. Patients with neurological impairment had increased levels of blood-based biomarkers including GFAP, TGFβ and IL8 with levels of TGFβ that correlated with BBB permeability and structural brain changes. Peripheral blood mononuclear cells isolated from unaffected and long COVID patients had persistent upregulation of inflammatory markers including IFNA/G and showed increased adhesion to human brain endothelial cells in vitro. Finally, exposure of endothelial cells to serum from long COVID patients induced increases in ICAM-1, VCAM-1 and TNF irrespective of neurological sequelae. Together, these data suggest that sustained systemic inflammation and persistent localised BBB dysfunction is a feature of long COVID-associated neurological impairment. Importantly, this may also be therapeutically relevant in the treatment and clinical management of this patient group.
Title of manuscript: Gamma-rays induced genome wide stable mutations in cowpea deciphered through whole genome sequencing
Authors: Punniyamoorthy Dhanasekar , Jegadeesan Souframanien
Published: January 2023

Gamma-rays are the most widely exploited physical mutagen in plant mutation breeding. They are known to be involved in development of more than 60% of global cowpea mutant varieties. Nevertheless, the characteristics of genome wide mutations induced by gamma-rays has not been studied in cowpea (Vigna unguiculata (L.) Walp.). In the present investigation, mutations elicited by gamma rays in three cowpea mutant lines in M6 generation were characterized through whole-genome sequencing. Gamma rays induced a relatively higher frequency (91.1%) of single base substitutions (SBSs) with an average transition to transversion ratio (Ti/Tv) of 2.82. A>G transitions including its complementary T>C transitions predominated the transition mutations, while all the four types of transversion mutations were detected with almost equal frequencies (5.6% to 7.4%). Indels constituted about 9% of the total induced variation wherein small insertions (5.3%) were relatively more prominent than small deletions (3.7%). Among the indels, single base indels and in particular those involving A/T bases showed preponderance, albeit indels of up to five bases were detected in low proportions. Distributed across all 11 chromosomes, only a fraction of SBSs (19.3%) and indels (12.7%) potentially altered the encoded amino-acids/peptides. The inherent mutation rate induced by gamma-rays in cowpea was observed to be in the order of 1.76 x 10-6 per base pair. Therefore, gamma-rays with greater tendency to induce SBSs and to a lesser extent indels could be efficiently and effectively exploited in cowpea mutation breeding.
Application value of Ki67 and serum CA125 in the deep myometrial invasion of endometrial cancer
Authors: Qin Lin
Published: January 2023

Objective To investigate the application value of Ki67 and serum CA125 in diagnosing the deep myometrial invasion of endometrial cancer.
Methods This study retrospectively analyzed 80 EC patients, who underwent procedure from January 2018 to June 2021 at Senior Department of Obstetrics & Gynecology, the Seventh Medical Center of PLA General Hospital assigned to the Fourth Medical Center. The general clinical data, serum CA125 and Ki67 levels were compared between the superficial muscular infiltration group and the deep myometrial invasion group. We investigated the application value of Ki67 and serum CA125 in diagnosing the deep myometrial invasion of EC by the ROC curve.
Results 80 patients were retrospectively analyzed, and 53 cases were superficial muscular infiltration, 27 cases were deep myometrial invasion. There was significant difference in age, tumor diameter, lymph node metastasis, Ki67, serum CA125, p53 status, serum CA125 and Ki67 levels between the two groups (p<0.05). As high as 35% of Ki67 was the optimal cutoff value for predicting DMI in EC, and the area under ROC curve was 0.691, the sensitivity and specificity of diagnosis were 88.9% and 56.6%. As high as 43.645 U/ml of serum CA125 was the optimal cutoff value for predicting DMI in EC, and the area under ROC curve was 0.668，the sensitivity and specificity of diagnosis were 40.7% and 92.5%. After combined detection of both, the area under ROC curve was 0.719, and its sensitivity and specificity of diagnosis were 96.3% and 43.4%.
Conclusion Serum CA125 and Ki67 may be used to evaluate DMI in patients with EC, and the diagnostic value of combination is higher, which provide reference for clinical treatment.
The visceral adipose tissue bacterial microbiota provides a signature of obesity based on inferred metagenomic functions
Authors: Sun Jiuwen , Germain Alberic , Kaglan Gracia , Lelouvier Benjamin , Servant Florence , Federici Massimo , Fernández-Real José Manuel , Sala Daniela Tatiana , Neagoe Radu , Bouloumié Anne , burcelin Remy
Published: January 2023

Metabolic inflammation mediated obesity requires bacterial molecules to trigger immune and adipose cells leading to inflammation and adipose depot development. Beside the established gut microbiota dysbiosis we and others identified a leaky gut in obese patients and animal models as notably characterized by the existence of a tissue microbiota in the adipose fat pads. To identify its potential role, we here sequenced the bacterial 16S rRNA genes within the visceral adipose depot of obese patients. Immense surgical, biochemical and bioinformatic care were taken to avoid environmental contaminants. We performed different statistical discriminant analyses to identify specific signatures and constructed network of interactions between variables. The data show that a specific 16SrRNA gene signature was composed of numerous bacterial families discriminating lean versus obese and extremely obese patients. Burkholderiaceae, Yearsiniaceae, and Xanthomonadaceae were the main discriminant families, notably all gram negative. Interestingly, the Morganellaceae were totally absent from non-obese while preponderant in all obese patients. To generate hypotheses regarding their potential role we inferred metabolic pathways from the 16SrRNA gene signatures. We identified several pathways associated with adenosyl-cobalamine previously described to be linked with adipose tissue development. We further identified chorismate biosynthesis involved in aromatic amino-acid metabolism which could be important players. This innovative approach generates novel hypotheses regarding the gut to adipose tissue axis in obesity.
Optimal partial regularity of discontinuous sub-elliptic systems with VMO coefficients related to H\"{o}rmander's vector fields
Authors: Zhu Yan , Wang Jialin , Liao Dongni
Published: January 2023

In this paper, we study the discontinuous sub-elliptic systems with VMO coefficients related to Hörmander's vector fields. In the case of growth exponential p ≥ 2, the regularity results of the partial Hölder continuity of weak solutions are established based on the 𝓐-harmonic approximation method under the controllable growth condition.
Effectiveness of emergent coastal vegetation as a defence system to mitigate debris load on a structure during extreme event
Authors: Gupta Aditya , Behera Manasa R.
Published: January 2023

Recent research has shown the effectiveness of a vegetation patch in reducing the fluid force of a tsunami wave or storm surge. However, according to the author’s knowledge, the research on the loading behaviour of debris such as shipping containers in presence of these coastal defence system does not exist. This paper, therefore, elucidates the behaviour of impact loading on a column structure due to modeled shipping container in presence of rigid staggered vegetation (RSV) and Tilting staggered vegetation (TSV) with relevance to Reduced Fluid Force Index (RFI), Reduced Momentum Index (RMI) and Transmission coefficient (CT). The non-linearities and the free surface of the fluid are dealt with Smoothed Particle Hydrodynamics (SPH) and the dynamics of vegetation tilt are dealt using Differential Variational Inequality (DVI). The experimental study is conducted for the quantification of debris impact loads on the structure and is then numerically simulated by introducing a vegetation patch in the flume to mitigate this extreme impact loading. Finally, a relationship between trunk tilting and its corresponding underestimation of peak debris impact load on a column structure for half emerged vegetation patch is shown. This study provides significant understanding on the effect of coastal vegetation in mitigating peak debris impact.
Gas Metal Arc Welding parameters obtainment via Artificial Neural Networks: a study of the influence of resampling in the experimental field on prediction error
Authors: Melgaço Ivis Fernanda Teles Alves , Lima Eduardo José , Alves Helias Raphael Teles
Published: January 2023

Welding is the most important metal bonding process used in industry, with applications ranging from microelectronic to structural as in oil prospection constructions. Control processes in electric arc welding aim to improve the quality of the generated weld bead and also to increase process repeatability. In addition to the above factors, robotic welding minimizes the need for a highly skilled operator, reduces waste caused by failures during the welding process as well as human losses and environmental damage. Proper prediction of welding parameters can be understood as the path to process repeatability as well as guaranteed weld quality. Artificial Neural Networks (ANN) are mathematical models that resemble biological neural structures with computational capacity acquired through learning and generalization. With the ability to learn by example and to generalize information one can consider a great ally in problem solving. The general objective of this work is to evaluate the effect of replication resampling on artificial neural networks applied in the prediction of robotic Gas Metal Arc Welding (GMAW) welding parameters. Replications of 2, 3, 5, 10, 20 and 100 times were used. Replication of 2 times the number of samples presented the smallest error among the researched ones.
Sunlight active cellulose/g-C3N4/TiO2 nano-photocatalyst for degradation of industrial dye and pharmaceutical drug in real wastewater
Authors: Garg Anushka , Chauhan Anjali , Agnihotri Charu , Singh Bhim Pratap , Mondem Vasundhara , Basu Soumen , Agnihotri Shekhar
Published: January 2023

The paper critically addresses two contemporary environmental challenges: the water crisis and the unrestricted discharge of organic pollutants in waterways together. An eco-friendly method was used to fabricate a cellulose/g-C3N4/TiO2 photocatalytic composite that displayed a remarkable degradation of methylene blue dye and atenolol drug under natural sunlight. Introducing graphitic carbon nitride (g-C3N4) onto pristine TiO2 improved hybrid material’s photonic efficacy and enhanced interfacial charge separation. Furthermore, immobilizing TiO2/g-C3N4 on a semi-interpenetrating cellulose matrix promoted photocatalyst recovery and its reuse, ensuring practical affordability. Under optimized conditions, the nano-photocatalyst exhibited ~95% degradation of both contaminants within two hours while retaining ~55% activity after ten cycles demonstrating a promising photostability. The nano-photocatalyst causes 66% and 57% reduction in COD and TOC values in industrial wastewater containing these pollutants. The photocatalysis was fitted to various models to elucidate the degradation kinetics, while LC-MS results suggested the mineralization pathway of dye majorly via ring opening demethylation. >98% disinfection was achieved against E. coli (10-105 CFU∙mL-1) contaminated water. This study thus paves multifaceted strategies to treat wastewater contaminants at environmental levels employing nano-photocatalysis.
A New Stable Boundary Layer Parameterization for Weather and Forecasting Models: a Heat Flux Budget Approach
Authors: Maroneze Rafael , Costa Felipe Denardin , Acevedo Otávio Costa , Medeiros Luiz Eduardo , Puhales Franciano Scremin , Anabor Vagner , Mortarini Luca
Published: January 2023

The present study introduces a new boundary layer parameterization for weather and forecasting models. It is implemented here as a boundary layer module in Weather Research and Forecasting (WRF) model. The main novelty in the new scheme is that it includes prognostic equations for the heat flux and temperature variance, being the first WRF boundary layer scheme with that feature. This is specially aimed at improving the representation of nocturnal stable boundary layer and of its turbulence regimes, weakly and very stable. The effort is supported by previous studies that found that the two regimes and the transitions between them are better represented by simplified numerical schemes that represent the interactions between the surface and the air adjacent to it when the heat flux and temperature variance are solved prognostically. The results show that the two regimes are adequately simulated by the new scheme. Such an evaluation is presented in terms of the relationship between the turbulence velocity scale and mean wind speed, of the dependence of the potential temperature gradient near the surface and the mean wind speed, and by the relationship between flux and gradient Richardson numbers. In the new scheme, the relationship between thermal structure and the mean and turbulent flows arises naturally from the heat flux prognostic equation, not being arbitrarily imposed by an empirical stability function.
Investigation of Mg-doping effect on the activity and P tolerance of V2O5-MoO3/TiO2 catalysts for NH3-SCR
Authors: qi liqiang , Li Silan , Wang Wen , Li Jingxin
Published: January 2023

V2O5-MoO3/TiO2 catalyst modified by Mg was studied to obtain higher NOx SCR activity and higher P, SO2 and H2O resistance than the V2O5-MoO3/TiO2. The results show that Mg modification can promote the denitration activity of V2O5-MoO3/TiO2 catalyst, and the maximum NOx removal efficiency of Mg1-SCR catalyst was 97.5%, the optimum reaction temperature and flow rate were 350℃ and 1200 ml/min, respectively. Mg doping can broaden the reaction temperature window of the catalyst, and the denitration efficiency can reach more than 87% at 300℃. P2O5 solution was prepared as poisoning precursor and mixed with catalyst to simulate the process of catalyst P-poisoning. The step-wise study showed that Mg0.5-SCR and Mg1-SCR catalyst displays higher durable resistance to P, SO2 and H2O than original catalyst. The catalysts have been characterized by XRD, BET, SEM, TEM, XPS, CO2-TPD, NH3-TPD and H2-TPR. The obtained results suggested that the Mg doping made the active components more dispersed on the surface of the supports, improved the thermal stability of the catalyst, promoted the transition of VOx from monomeric state to polymerized state, inhibited the interaction between P and V, and protected the acid site.
Forming nursing home practices that support quality care for residents. A qualitative observational study
Authors: Stokke Randi , Sogstad Maren , Wibe Torunn
Published: January 2023

Background
Residents of nursing homes are increasingly frail and dependent. At the same time, there are increased demands for quality of care and social life for individual residents. In this article, we explore how care workers provide quality care, including meaningful activities and social life in shared living rooms in nursing homes.
Methods
An ethnographically inspired design was applied, and a purposive sample of six units for long-term care in three nursing homes in Norway was included in the study. Data were collected by participant observation, including informal conversations with the staff and residents, and the data were analysed using thematic analysis.
Results
The analysis identified three main themes: working within the given frames, forming practices, and organising activities. The empirical findings demonstrate that care takes place within given frames of architecture, culture, and resources, focusing on meeting residents’ physical and social needs and aiming for a social life.
Conclusions
The results of this study illustrate that nursing home practices are focused on residents as a group. However, care workers take advantage of personal skills and resources to work towards person-centred care within the given frames. The quality of care is recognised in terms of how care workers meet individual residents’ needs. The quality of care seems highly related to the competence, capability, and skills of individual care workers.
Cross-sectional association between red blood cell distribution width and regional cerebral tissue oxygen saturation over the first 14 days in preterm infants
Authors: Mu Yuju , Wang Hua , Tian Mengting , Hu Yong , Feng Yi , Lu Ruifeng , He Qi , Jiang Shouliang , Huang Jinglan , Duan Surong , Mu Dezhi
Published: January 2023

Background: Hypoxia can threaten the metabolic functions of various body systems of the immature neonate, particularly the central nervous system. Red blood cell distribution width (RDW) has been recently reported as a prognostic factor in neurologic diseases. This study examined the correlation between RDW and regional cerebral tissue oxygen saturation (rcSO2).
Methods: This cross-sectional study, including 110 preterm infants with gestational age (GA) of <32 weeks or birth weight (BW) of <1500 g from January to June 2022 in our institution, monitored rcSO2 with near-infrared spectroscopy. RDW was extracted from the complete blood count during the first 14 days of life. RDW and rcSO2 measurements were analyzed using a cross-sectional research method.
Results: This study included 53 preterm neonates with rcSO2≥55% and 57 preterm neonates with rcSO2<55%. Mean rcSO2 decreased with increasing RDW during the first 14 days of life. Significantly higher RDW levels were seen in the low rcSO2 group compared with those of the high rcSO2 group. According to threshold effect analysis, the value of rcSO2 decreased with RDW levels above 17.84% (β, -0.03; 95% CI, -0.04– -0.02; p<0.0001). After adjusting for potential confounders, an RDW of ≥17.84% was determined as the predictive cutoff value for preterm infants with low rcSO2 (Model I: OR, 3.31; 95% CI, 1.36–8.06; p=0.009; and Model II: OR, 3.31; 95% CI, 1.28–8.53; p=0.013).
Conclusions: An RDW of ≥17.84% was associated with a high risk of low rcSO2 in preterm infants. A high RDW in preterm infants correlates with an increased risk of cerebral hypoxia.
Trial registration: This study was registered at ChineseClinicalTrials.gov (09/04/2022,ChiCTR2200058482).
Myopic Emotion-Reason Dilemma Judgment (MERDJ): A Spiking Neuron Model of Moral Judgment in Trolley Dilemmas
Authors: Gothard Timothy , Davies Jim
Published: January 2023

People will make different moral judgments in similar moral dilemmas where one can act to sacrifice some number of lives to save several more. Research has shown that although people can reason that an action would save more lives, automatic processes can overwrite deliberate reasoning (J.D. Greene, Morelli, Lowenberg, Nystrom, & Cohen, 2008; J.D. Greene, Sommerville, Nystrom, Darley, & Cohen, 2001). Having participants imagine hypothetical moral dilemmas, researchers have discovered that factors such as action/omission, means/side-effect, and personal/impersonal can affect judgment. Joshua Greene suggests that these features do not affect people’s judgment because they are morally relevant but are instead a result of the myopic nature of the automatic moral process (J.D. Greene, 2013). Greene hypothesizes that there is some myopic module (2013) or domain-general (2017) process that attaches a negative emotional response to an action when one is contemplating violent actions. In the present research a model of this myopic automatic process is paired with an analytic system to replicate deontological and utilitarian responses to moral dilemmas. Our system, MERDJ, models this in simulated spiking neu-rons. The system takes in representations of specific moral dilemmas as inputs and outputs judgments of appropriate or inappropriate.
OmegaROP-2 prospective study: Expression of placental fatty acid receptors in preterm newborns with retinopathy of prematurity
Authors: Carré Chloé , Acar Niyazi , Daruich Alejandra , Grégoire Stéphane , Martine Lucy , Buteau Bénédicte , Aho Serge , Eid Petra , Arnould Louis , Bron Alain , Driessen Marine , Kermorvant Elsa , Simon Emmanuel , Creuzot-Garcher Catherine , Gabrielle Pierre-Henry
Published: January 2023

Background

Incomplete vascularization of the retina in preterm infants carries a risk of retinopathy of prematurity (ROP). Progress in neonatal resuscitation in developing countries has led to the survival of an increasing number of premature infants, resulting in an increased rate of ROP and consequently in visual disability. Strategies to reduce ROP involve optimizing oxygen saturation, nutrition, and normalizing factors such as insulin-like growth factor 1 and n-3 long-chain polyunsaturated fatty acids (LC-PUFA). Our previous study, OmegaROP, showed that there is an accumulation or retention of docosahexaenoic acid (DHA) in mothers of infants developing ROP, suggesting abnormalities in the LC-PUFA placental transfer via fatty acid transporting proteins. The present study aims to better understand the LC-PUFA transport dysfunction in the fetoplacental unit during pregnancy and to find a novel target for the prevention of ROP development.

Methods

The study protocol is designed to evaluate the correlation between the expression level of placental fatty acid receptors and ROP occurrence. This ongoing study will include 100 patients: patients giving birth before 29 weeks of gestational age (GA) and patients with full-term pregnancies. Recruitment is planned for over 46 months. Maternal and cord blood samples as well as placental tissue samples will be taken following delivery. ROP screening will be performed using wide-field camera imaging according to the International Classification of ROP consensus statement.

Discussion

The results of this study will have a tangible impact on public health. Indeed, if we show a correlation between the expression level of placental omega-3 receptors and the occurrence of ROP, it would be an essential step in discovering novel pathophysiological mechanisms involved in this retinopathy.
Trial registration: 2020-A03253-36