bluuebunny/crossref_metadata_2025 huggingface dataset:
Triplet Phenylarsinidene and Its Oxidation to Dioxophenylarsine
Authors: Qian Weiyu , Schreiner Peter R. , Mardyukov Artur
Published: February 2023

Diradicals are key intermediates involved in numerous chemical processes and have attracted considerable attention in synthetic chemistry, biochemistry, and materials science. Even though parent arsinidene (H-As) has been characterized well, the high reactivity of subsituted arsinidenes has prohibited their isolation and characterization to date. Here, we report the preparation of triplet phenylarsinidene through the photolysis of phenylarsenic diazide, isolated in an argon matrix, and its subsequent characterization by infrared and UV/Vis spectroscopy. Doping the matrices containing phenylarsinidene with molecular oxygen leads to the formation of hitherto unknown anti-dioxyphenylarsine. The latter undergoes isomerization to novel dioxophenylarsine upon 465 nm irradiation. The assignments were validated by isotope-labeling experiments combined with B3LYP/def2-TZVP computations.
Altering the Spectroscopy, Electronic Structure, and Bonding of Organometallic Curium(III) Upon Coordination of 4,4-bipyridine
Authors: Long Brian , Beltran-Leiva Maria , Sperling Joseph , Poe Todd , Celis-Barros Cristian , Albrecht-Schoenzart Thomas
Published: February 2023

Structural and electronic characterization of (Cp'3Cm)2(4,4'-bpy) (Cp' = trimethylsilylcyclopentadienyl, 4,4'-bpy = 4,4'-bipyridine) is reported and provides a rare example of curium-carbon bonding. Cp'3Cm displays unexpectedly low energy emission that is quenched upon coordination by 4,4'-bipyridine. Electronic structure calculations on Cp'3Cm and (Cp'3Cm)2(4,4'-bpy) rule out significant differences in the emissive state, rendering 4,4'-bipyridine as the primary quenching agent. Comparisons of (Cp'3Cm)2(4,4'-bpy) with its samarium and gadolinium analogues reveal atypical bonding patterns and electronic features that offer insights into bonding between carbon with f-block metal ions.
Elecciones presidenciales en el Perú: minería de textos de los editoriales del diario La República
Authors: Castro Cáceres Mariela Lucina , Chávez Salazar David Alejandro , Urbizagástegui Alvarado Rubén
Published: February 2023

Analiza los editoriales del periódico peruano La República publicados del 5 de mayo al 6 de junio de 2021, fechas en las que se llevaron a cabo las campañas políticas de la segunda vuelta electoral para ocupar la presidencia del Perú. Se pretende descubrir información relevante para entender el uso de las terminologías comunicadas a través del lenguaje escrito en ese periódico. Mediante la técnica de minería de texto y los algoritmos de aprendizaje automático para el análisis de los datos no estructurados, se creó un dendrograma y clústeres para validar y estimar las agrupaciones de los términos más frecuentes. En relación a cada candidato, el análisis de regresión muestra una asociación diferenciada en el uso de las palabras. Estas palabras conforman una red que expresa la coyuntura política del período en estudio y se refuerza con la construcción de una nube de palabras de mayor frecuencia de uso. Se concluye que los medios de comunicación construyen sus propias representaciones sociales sobre diversos temas locales y nacionales de modo que consciente o inconscientemente evidencian sus preferencias. Estas preferencias no son ajenas en los editoriales del diario La República. La importancia de realizar este tipo de estudio radica en el potencial que tiene la teoría de las representaciones sociales para colocar al investigador frente a la posición que tienen los sujetos, que construyen y comunican los embates antagónicos de la realidad social nacional.
Loss of dyskerin facilitates the acquisition of metastatic traits by altering the mevalonate pathway
Authors: Andrades Evelyn , Toll Agustí , Deza Gustavo , Segura Sonia , Gimeno Ramón , Espadas Guadalupe , Sabidó Eduard , Haro Noemí , Pozo Óscar J , Bódalo Marta , Torres Paloma , Pujol Ramon M , Hernández-Muñoz Inmaculada
Published: February 2023

The initial dissemination of cancer cells from many primary tumors implies intravasation to lymphatic nodes or blood vessels. To investigate the mechanisms involved, we analyzed the expression of small non-coding RNAs in cutaneous squamous cell carcinoma (cSCC), a prevalent tumor that mainly spreads to lymph nodes. We report the reduced expression of small nucleolar RNAs in primary cSCCs that metastasized when compared to non-metastasizing cSCCs, and the progressive loss of DKC1 (dyskerin, which stabilizes the small nucleolar RNAs) along the metastasis. DKC1 depletion in cSCC cells triggered lipid metabolism by altering the mevalonate pathway and the acquisition of metastatic traits. Treatment of DKC1-depleted cells with simvastatin, an inhibitor of the mevalonate pathway, blocked the expression of proteins involved in the epithelial-to-mesenchymal transition. Consistently, the expression of the enzyme 3-hydroxy-3-methylglutaryl-CoA synthase 1 was associated with pathological features of high metastatic risk in cSCC patients. Our data underpin the relevance of the mevalonate metabolism in metastatic dissemination and pave the possible incorporation of therapeutic approaches among the antineoplastic drugs used in routine patient care.
PERBANDINGAN HASIL ANALISIS FINITE ELEMENT UNTUK STABILITAS DAN PENURUNAN TIMBUNAN DENGAN BEBERAPA SOIL MODEL DI LOKASI RENCANA PEMBANGUNAN JALAN TOL SUBANG
Authors: Hamonangan Efran Kemala , Syahputra Muhammad Yoke
Published: February 2023

Abstract

 

The challenge in designing the Subang Toll Road lies in the original soil conditions, with soil consistency between very soft and soft. This soft soil has low bearing capacity, high compressibility, and low permeability. Soil improvement using soil replacement has been common for soft soil conditions that are not thick, and this soil improvement can increase the bearing capacity of the soil and reduce the thickness of compressible soil. This study aims to perform embankment modeling using PLAXIS 2D software version 22, by comparing 3 soil models, namely the Mohr Coulomb, Hardening Soil, and Soft Soil models. Based on the modeling results, the Advanced Soil Model has a better approach compared to the Mohr Coulomb Model, which is a simple model. The results show that the Hardening Soil Model produces a settlement value that is closest to the results of 1-dimensional Terzaghi calculations. In addition, the Hardening Soil Model is the most conservative soil model, because it provides the highest settlement value, highest excess pore water pressure, and the lowest safety factor.

 

Keywords: toll road; soil consistency; soft soil; soil replacement; soil model

 

 

Abstrak

 

Tantangan dalam perancangan Jalan Tol Subang adalah pada kondisi tanah asli, dengan konsistensi tanah antara sangat lunak hingga lunak. Tanah lunak ini memiliki daya dukung yang rendah, kompresibilitas yang tinggi, dan permeabilitas yang rendah. Perbaikan tanah menggunakan soil replacement telah biasa dilakukan, untuk kondisi tanah lunak yang tidak tebal, dan perbaikan tanah ini dapat meningkatkan daya dukung tanah serta mengurangi tebal tanah kompresibel. Studi ini bertujuan untuk melakukan pemodelan timbunan dengan menggunakan perangkat lunak PLAXIS 2D versi 22, dengan membandingkan 3 soil model, yaitu model-model Mohr Coulomb, Hardening Soil, dan Soft Soil. Berdasarkan hasil pemodelan yang dilakukan, Advanced Soil Model merupakan pendekatan yang lebih baik dibandingkan dengan Mohr Coulomb Model, yang merupakan model sederhana. Hasil yang diperoleh menunjukkan bahwa Hardening Soil Model menghasilkan nilai penurunan yang paling mendekati hasil perhitungan 1 dimensi Terzaghi. Selain itu, Hardening Soil Model merupakan soil model yang paling konservatif, karena memberikan nilai penurunan yang terjadi dan angka air pori ekses yang paling tinggi serta nilai faktor keamanan yang paling rendah.

 

Kata-kata kunci: jalan tol; konsistensi tanah; tanah lunak; soil replacement; soil model
SAMBUL: SANDAL TIMBUL DENGAN MENGAPLIKASIKAN FUNGSI HURUF BRAILE YANG DILENGKAPI SENSOR SUARA GUNA MEMUDAHKAN PARA PENYANDANG TUNANETRA SAAT BERJALAN DI TROTOAR
Authors: Insaniyah Khoirotun Nisa’
Published: February 2023

Abstract

 

Not all humans in this world are born with normal physical conditions. Some of them have physical disabilities, one of which is blind. There are many problems experienced by blind people so far. One of them is that they are not aware when they are walking on the sidewalk. This is of course very dangerous for them. Based on these problems, a tool for the blind was designed in this research, in the form of embossed sandals or SAMBUL, which can be used by the blind to travel, especially on the sidewalk. With the results of this study, it is hoped that the Government can help turn the resulting designs into ready-to-use items, so that they can help blind people when walking on the sidewalks.

 

Keywords: disability; blind; Braille letters; embossed sandals; SAMBUL; sidewalk

 

 

Abstrak

 

Tidak semua manusia di dunia ini dilahirkan dengan kondisi fisik yang normal. Beberapa di antara mereka memiliki kelainan fisik, yang salah satunya ialah tunanetra. Banyak permasalahan yang dialami oleh penyandang tunanetra selama ini. Satu di antaranya ialah bahwa mereka tidak sadar jika sedang berjalan di trotoar. Hal ini tentu sangat berbahaya bagi mereka. Berdasarkan permasalahan tersebut, pada penelitian ini dirancang sebuah alat bagi penyandang tunanetra, berupa sandal timbul atau SAMBUL, yang dapat digunakan oleh para penyandang tunanetra untuk melukan perjalanan, khususnya di trotoar. Dengan adanya hasil penelitian ini, diharapkan Pemerintah dapat membantu mewujudkan desain yang dihasilkan menjadi barang siap pakai, sehingga dapat membantu para penyandang tunanetra saat berjalan di trotoar.

 

Kata-kata kunci: disabilitas; tunanetra; huruf braile; sandal timbul; SAMBUL; trotoar
In vitro efficacy of essential oils against Haematobia irritans
Authors: Castro Karina Neoob de Carvalho , Costa-Júnior Lívio Martins , Canuto Kirley Marques , Andrade Ivanilza Moreira de , Minho Alessandro Pelegrine , Souza Francisco de Assis Leite
Published: February 2023

The horn fly (Haematobia irritans) infestation in the cattle in Brazil leads to significant economic damage for livestock. The efficacy of many essential oils has been demonstrated in the control of veterinary ectoparasites. This study aimed to evaluate the in vitro efficacy of four essential oils to adult horn fly control. The essential oil from Mesosphaerum suaveolens (L.) Kuntze (Lamiaceae) was extracted by hydro-distillation, while that the water steam distillation method was used to extract the essential oils from Varronia curassavica (Jacq.) Roem. & Schult. (Boraginaceae), Alpinia zerumbet (Pers.) B.L. Burtt & R.M. Sm. (Zingiberaceae) and Psidium guajava L. (Myrtaceae). Afterwards, all the essential oils were analyzed by Gas Chromatography Mass Spectrometry (GC?MS) and Flame Ionization Detector (GC-FID) for determination of their chemical composition. The bioassays in vitro were performed according to the impregnated filter paper methodology. All the essential oils evaluated in this study exhibited efficacy in vitro against H. irritans. The highest mortality of H. irritans was determined by essential oils from A. zerumbet (100%) and M. suaveolens (96.2%) at 50 mg mL-1.  In concentration of 100 mg mL-1 V. curassavica and P. guajava essential oils caused the mortality of 99.2% and 82.8%, respectively. The A. zerumbet, M. suaveolens, V. curassavica and P. guajava essential oils showed in vitro efficacy against H. irritans. Further studies with associations and nanoemultions are necessary to increase the efficacy and stability of these essential oils on field conditions.
Vulnerability and Resilience to Natural Hazards among New Zealand’s Laotians
Authors:   , Konemixay Vannaly
Published: February 2023

Linguistic and cultural minorities such as migrants and refugees are particularly more vulnerable to natural hazards than the general population. Laotian New Zealanders are one such group who are not only a cultural minority but are numerically a very small group in New Zealand. Minority groups such as Laotian New Zealanders may lack capital assets to sustain their livelihoods, hence might find it more difficult to build resilience to natural disasters. Therefore, this thesis explores these twin issues of vulnerability and resilience through a Sustainable Livelihood Approach (SLA). SLA is a commonly used as a framework that analyzes human, social, natural, physical and financial capital. Using SLA I examined how such a framework can identify vulnerabilities felt by Laotian New Zealanders amidst natural hazards and how SLA can help build resilience during times of natural disasters. By employing a qualitative research approach, semi-structured interviews were carried out with 25 Laotian New Zealanders. Due to the COVID-19 pandemic, most interviews were conducted online and digitally recorded. By applying a thematic analysis main themes were identified and analysis was conducted using these themes as well as a review of government policy documents.

Study results revealed that Laotian participants feel vulnerable due to language barriers and cultural discrimination. At the same time, they feel resilient since they possess some form of human, financial, physical and social capital to sustain their livelihood. These include savings, insurance, strong family and community supports, and government support. These juxtaposing ideas led me to conclude that Laotian New Zealanders seem to be both vulnerable and resilient amidst natural disasters in New Zealand.
The Role of Skills Competitions in Improving the Practical Ability of Vocational College Students
Authors: Wang Shang , Peng Fei , Feng Zhixin
Published: February 2023

Vocational education and general education are two different types of education that are equally important. The orientation of talent training in vocational education is to nurture skilled talents to serve the society. The practical ability of students is both the focus of teaching in vocational colleges and the requirement of enterprise posts. The various types of skills competitions provide a “stage” for students to showcase their abilities. First, this paper explores students’ problem-solving ability while preparing for these competitions, expounding the importance of vocational education and skills competitions. Second, this paper summarizes the views of different scholars. Third, based on a specific case, this paper describes the improvement in students’ ability while preparing for these competitions. Fourth, this paper analyzes the results of the questionnaire survey conducted to investigate the improvement in students’ ability. Lastly, this paper puts forward several suggestions that appeal for vocational colleges to pay more attention to skills competitions.
Tingkat Status Gizi dan Kondisi Fisik pada Atlet Sepakbola Sonic Football Academy Kabupaten Nganjuk Tahun 2020
Authors: Alfiansyah Robin , Rizky Muhammad Yanuar , Firdaus Mokhammad
Published: February 2023

Latar Belakang: Semua cabang olahraga membutuhkan kesiapan fisik, penguasaan teknik, dan status gizi  yang baik di samping faktor mental dan emosional. Selain itu, status gizi merupakan bagian dari faktor penentu keberhasilan pencapaian prestasi tinggi. Cabang olahraga sepakbola sangat membutuhkan komponen tersebut dan memegang peranan penting. Permainan sepakbola merupakan cabang olahraga dinamis dengan tingkat intensitas yang tinggi baik saat bertahan maupun saat menyerang. Oleh karena itu cabang olahraga sepakbola merupakan permainan yang tidak hanya membutuhkan kondisi fisik yang baik, tetapi juga status gizi yang baik pula. Tujuan dilakukannya penelitian ini adalah untuk mengetahui tingkat status gizi dan kondisi fisik meliputi aerobic endurance, flexibility (kelentukan), agility (kelincahan), dan speed (kecepatan) pemain sepakbola Sonic Football Academy Kabupaten Nganjuk.Metode: Penelitian ini menggunakan teknik deskriptif kuantitatif. Dimana populasi adalah seluruh pemain sepakbola Sonic Football. Kemudian menggunakan teknik purposive sampling, sehingga menghasilkan sampel yaitu 25 pemain yang berusia 16 tahun.Hasil: Status gizi kriteria normal dan gemuk ringan, aerobic endurance kriteria baik, cukup, kurang dan sangat kurang, flexibility kriteria baik sekali, baik, dan sedang, agility kriteria excellent, dan above average, speed kriteria baik sekali, baik sedang, dan kurang.Kesimpulan: Tingkat status gizi dan kondisi fisik pemain sepak bola Sonic Football Academy Kabupaten Nganjuk tahun 2020 memiliki rata-rata dengan kategori baik, dan memiliki tingkat status gizi rata-rata dengan kategori normal atau ideal.
Survei Tingkat Kemampuan Power dan Kekuatan Otot Tungkai pada Atlet SSB Putra Perseta 88 Tahun 2020
Authors: Putra Deden Fransiska Rendi , Puspodari Puspodari , Firdaus Mokhamad
Published: February 2023

Latar Belakang: Unsur power otot tungkai dan kekuatan otot tungkai termasuk komponen kondisi fisik yang mendasar dalam cabang olahraga sepakbola.Metode: Jenis penelitian ini merupakan non eksperimen dengan menggunakan metode pendekatan deskriptif kuantitatif. Subjek penelitian ini merupakan 20 orang atlet SSB Putra Perseta88. Teknik sampling yang digunakan yaitu teknik sampling jenuh. Instrumen pengumpulan data berupa tes vertical jump untuk mengetahui power otot tungkai dan tes back and leg dynamometer untuk mengetahui kekuatan otot tungkai.Hasil: Data terkait tingkat kemampuan power otot tungkai relevansinya dengan prasyarat menunjukkan bahwa pada atlet SSB Putra Perseta88 yaitu 5% dengan kategori baik, 20% dengan kategori baik, 50% di kategori sedang, 10% di kategori kurang dan 15% di kategori kurang sekali. Kemudian pada kekuatan otot tungkai yaitu 15% di kategori baik sekali, 15% di kategori baik, 45%, di kategori sedang, 20% di kategori kurang dan 5% di kategori kurang sekali.Kesimpulan: Rata-rata kemampuan power tungkai sedang.
Analisis Teknik Dasar Bermain Futsal Timnas Putri Indonesia Pada Piala AFC Woman’s Championship Tahun 2018
Authors: Ditya Agischa Rike , Wahyudi Heri
Published: February 2023

Latar Belakang: Teknik dasar adalah suatu keterampilan dan kemampuan seseorang untuk bergerak secara efektif dengan memiliki satu tujuan. Keberhasilan melakukan teknik dasar tersebut dapat dilihat dalam pertandingan Timnas Futsal Putri Indonesia melawan Macau pada Piala AFC Women Futsal Championship di Thailand tahun 2018. Tujuan penelitian bedasarkan latar belakang tersebut adalah untuk mengetahui (1) Mendeskripsikan teknik dasar bermain yang digunakan dalam pertandingan piala AFC Women's Futsal Championship tahun 2018 (2) Mendeskripsikan banyaknya teknik dasar yang digunakan dalam hitungan persen.
Metode: Dengan menggunakan jenis penelitian kuantitatif metode deskriptif
Hasil: Ditemukan hasil penelitian sebagai berikut: terdapat empat teknik dasar yang digunakan Tim Nasional Futsal Putri di piala AFC Women’s Championship 2018 saat pertandingan berlangsung yaitu passing, dribbling, shooting, dan kontrol.
Kesimpulan: Teknik dasar yang paling banyak digunakan adalah kontrol sebanyak 41%, teknik pasiing dan dribbling memiliki selisih yang cukup tipis yakni sebanyak 4% dengan passing 28% dan dribbling 24%. Sedangkan teknik dasar shooting paling sedikit digunakan yakni 7%. Rincian dari teknik dasar jika dilihat dalam hitungan jumlah adalah 1) Passing sebanyak 371 dengan 329 passing dalam dan 42 passing luar. 2) Dribbling sebanyak 319 dengan 148 pertama dan 171 kedua. 3) Shooting sebanyak 93 dengan bola hidup 63 dan bola mati 30. 4) Kontrol sebanyak 540 dengan 281 pertama dan 259 kedua.
Rancangan Sistem Penyimpanan Arsip Surat Puskesmas Dengan Microsoft Access
Authors: Afifah Afifah , Yoyet Eva , Agustin Nila
Published: February 2023

Archives are records of activities that serve as a source of information when making decisions. Over time, archive management in various agencies began to require electronics and advances in information technology. Likewise, with archives at the health center, their management already requires an electronic touch, so finding and utilizing them can be done quickly. Based on these needs, an archive storage system was designed for the Pauh Health Center, located in one of the sub-districts in the city of Padang. Archive storage system designed based on Microsoft Access; this application was chosen because it is relatively easy to learn and is an application that is included in Microsoft Office. The design of this system uses data from puskesmas archives from 2020 to 2022. The application design consists of: a login menu, incoming and outgoing mail tables, relations between tables, incoming and outgoing mail forms, incoming and outgoing mail reports, and switchboard menus. The weakness of this system design is that it has not been able to provide different access rights between admins and ordinary visitors. Another weakness is that the application can only be used internally at the health center and cannot be connected to the Padang City Health Office.
Los paisajes de los geógrafos
Authors: Martínez de Pisón Eduardo
Published: February 2023

El paisaje entendido y propuesto por la geografía es una contribuciónconceptual y metodológica en los campos de la ciencia y la cultura, concontenidos propios, que aporta una imagen original de la Tierra. Lo manifiestanasí sus logros en los fundamentos integradores de los componentes del paisaje.Se muestra la contribución general al paisaje desde la geografía, se señala suimplantación original y se indican sus posibles orientaciones actuales.
Eros y compromiso. El nuevo realismo en la poesía de Erika Martínez
Authors: Morales Barba Rafael
Published: February 2023

La poesía española de corte realista inauguró nuevas rutas entre 1990-2000 buscando nuevas perspectivas frente a la claridad denotativa de los años 80, donde la nueva sentimentalidad pareció asumir protagonismo. Desde Jorge Gimeno o Carlos Pardo o incluso Josep María Rodríguez, comenzaron juegos con la sinécdoque y el fragmento, para mostrar una nueva manera de contar las cosas y que, en propuestas más recientes, han evolucionado hacia una angulación o perspectiva compleja, para retomar la idea de compromiso (cuidadosamente sorteada en el verso en los 80), ante las nueva realidad. La poesía de Erika Martínez responde a todo ello y supone, junto a la de Marisa martínez Pérsico, un nuevo camino que denota y sortea esos asuntos desde un realismo desconcertante a veces, y que se emplea en el "proema" como nueva fórmula acorde a los tiempos que corren.
Materialidades temporales: écfrasis y suspensión en "Ciencias ocultas" (2019) de Mike Wilson
Authors: De los Ríos Valeria
Published: February 2023

Este artículo aborda Ciencias ocultas de Mike Wilson a partir de la noción de descripción como opuesta a la narración. En la novela de Wilson las cosas descritas forman parte de una escena del crimen, el cual no es nunca resuelto, ya que la escritura se detiene en pos de la descripción de las cosas al interior de la escena del crimen. Entre estas, aparecen objetos cotidianos, pero también imágenes que son descritas en forma de écfrasis, figura paradigmática de la relaciones entre escritura e imagen. La obra de Wilson es leída a partir del marco propuesto por los nuevos materialismos que otorgan agencia a la materia, la cual posee un una potencia vibrante (Bennett). Uno de los principales efectos de la descripción en  Ciencias ocultas es la ralentización y la suspensión temporal.
Juan Benet y el “Afuera”: una lectura blanchotiana
Authors: Navajas Espinal Laura
Published: February 2023

El propósito de este artículo es analizar la obra de Juan Benet, concretamente su novela Un viaje de invierno, bajo la perspectiva del espacio literario blanchotiano y el pensamiento del Afuera foucaltiano desarrollado a partir de los presupuestos teóricos de Maurice Blanchot. Nos apoyaremos, para tal tarea, en los siguientes ensayos de Benet: “Elángel del Señor abandona a Tobías”; “Un extempore”; “Op. Posth” y “Un ensayo: La deuda de la novela hacia el poemareligioso de la antigüedad”. La propuesta es desvincular la hermenéutica en torno a la obra benetiana de los presupuestos histórico-político-sociales que condicionan su perspectiva de análisis y elaborar una nueva aproximación exegética centrada en la reflexión acerca del propio hecho literario, de su estrecha relación con la muerte, de la imposibilidad de experimentar lo acontecimental salvo como ausencia, como rastro o huella y de la inutilidad de toda memoria o testimonio.
La literatura como museo: los jardines entre la naturaleza y la historia
Authors: Gabrieloni Ana Lía
Published: February 2023

En diálogo con la historia de la pintura formal, pretendemos recuperar y reflexionar sobre imaginería literaria alojada en musées imaginaires que rehúye las categorías estéticas y tradicionales animando el origen y desarrollo del género para, en cambio, proporcionar un nuevo motivo paisajístico al repertorio clásico de los "loci horridi". Inusuales o directamente inverificables en la pintura de caballete, los jardines en ruinas tal como están descritos en dos novelas de Gustave Flaubert y Virginia Woolf sugieren considerar la función restauradora/museística de la literatura en el seno de la cultura visual. A la vez, estos jardines de extraordinaria orinalidad, que pueden verse como "paisajes de la devastación", reclaman una historia del arte irrestricta e inclusiva, alternativa a la canónica que permita reconocer y pensar las imágenes no solo a través de la literatura y la pintura, sino también a través de la historia de la naturaleza y la historia de la humanidad, mas no como diametralmente opuestas sino mutuamente complementarias. Entrelazadas y determinándose crucialmente una a la otra como en la novela Nevermore (2021) de la escritora y traductora francesa Cécile Wajsbrot, quien reconoce en la naturaleza abandonada a sí misma en el jardín de "Time Passes" de Woolf la imagen más "inquietante y trágica" de la devastación en la historia.
Benny Wenda’s Political Propaganda about the Free Papua Issue Through Twitter
Authors: Zahidi M. Syaprin
Published: February 2023

The purpose of this study was to explain the political propaganda of the free Papua issue spread by Benny Wenda via his Twitter account. This study used a qualitative approach to analyze Benny Wenda's Twitter account. The NVivo 12 Plus software was used in this study because it can process Benny Wenda's Twitter data. This research discovered Benny Wenda's Twitter propaganda of the free Papua issue divided into 11 important topics, namely "Occupation", "media", "independence", "colonial", "today", "support", "rights", "prisoners", "Political prisoners", "people" and "Papuan". The 11 topics were further broken down into several important topics related to the issue of an independent Papua. From the analysis of Benny Wenda's Twitter account, it was also found that support for the Papuan independence movement was spread in several regions, including North America, South America, Europe, Africa, Asia, and Australia. Despite this massive support, the UN has not recognized this movement, as stated by UN Secretary-General Antonio Guterres that Papua is part of Indonesian territory through uti possideti iuris, the NY Agreement of 1962, the Act of Free Choice of 1969, and UNGA resolution 2504 (XXIV) of 1969.
The Governance of School Operational Assistance (SOA) Funds for Elementary Schools in Medan
Authors: Harmen Hilma , Dalimunthe Muhammad Bukhori , Dewi Rosmala , Panggabean Fitri Yani , Dalimunthe Raudah Zaimah
Published: February 2023

This study aimed to test the measurement and structural models of SOA fund governance constructed by participation, transparency, and accountability. A total of 348 respondents were involved in this study consisting, including the headmaster (n=20), teachers (n=76), and parents (n=252). Data were collected using a questionnaire distributed to respondents using Google Forms for four months. Data analysis used confirmatory factor analysis through Partial Least Squares-Path Modeling (PLS-PM), which assisted the Smart PLS. Testing the measurement model using construct validity and internal consistency reliability showed two items (P4-participation and A3-accountability) having loading factors that do not satisfy the criteria. Likewise, both items were excluded from the model, which impacted the acceptance of the model fit. Furthermore, testing the quality of the structural model using the goodness of fit (GoF=0.524) was more significant than 0.36, which meant the quality of the structural model was very strong and significant. The transparency aspect had the most robust coefficient, which signals that everyone regarding the implementation of SOA funds in schools freely obtained the disclosure of financial and academic information. Other scholars can explore the role of the principal, teachers, and parents in making learning successful in schools by optimizing the use of SOA funds.
Evaluation of mammary gland health in dairy cows treated by pegylated granulocyte colony-stimulating factor
Authors: Tabery Josef , Andrlíková Michaela , Bína Vladislav , Hochmanová Adriena , Indrová Eva , Mizeráková Monika , Páleník Tomáš , Stařecká Veronika , Švédová Kateřina , Čech Svatopluk
Published: February 2023

The study aimed to determine the effect of the treatment by pegbovigrastim on the health of the mammary gland in dairy cows. Experimental animals were successively treated with 15 mg of pegylated bovine granulocyte colony-stimulating factor (bG-CSF, pegbovigrastim, PEG, Imrestor, Elanco) 10 ± 3 days before expected parturition and 1 day after actual parturition. Cows in the control group remained without treatment. The occurrence of clinical and subclinical mastitis in dairy cows during the first three months postpartum, and bacteriological findings in milk and milk yield were evaluated after preventive pegbovigrastim treatment. The influence of pegbovigrastim, as an additional treatment of mastitis caused by Streptococcus uberis in dairy cows on the standard course of treatment, was evaluated. The average number of antimicrobial (AML) interventions necessary for healing, the proportion of cows with 1, 2, 3 and more AML interventions, milk somatic cell count before treatment, 1 and 2 months after treatment and average milk withdrawal time were evaluated between groups. The results of the study did not find positive effects of pegbovigrastim on any evaluated variables.
Effect of sperm and glycerol concentration on epididymal sperm motility parameters after thawing
Authors: Andrlová Petra , Mráčková Miroslava , Jánová Eva , Kološ Filip , Sedlinská Markéta
Published: February 2023

The aim of this study was to evaluate the effect of different glycerol concentrations and different sperm concentrations on stallion epididymal sperm motility indicators after thawing. For statistical analysis, 25 stallions were used. Collection of the epidydimal spermatozoa was performed as a retrograde flush of cauda epididymis and ductus deferens within 12 h post castration. After evaluation, the resuspended spermatozoa were centrifuged, the supernatant removed and the spermatozoa resuspended in Gent semen extender to get three different groups with different concentrations of sperm (250 × 106 in ml, 500 × 106 in ml, 1000 × 106 in ml) and different final glycerol concentrations (2%, 4%, and 6%). Therefore, 9 different samples were finally obtained from each stallion. The spermatozoa were packed and placed in a fridge (4 °C) for 2 h, then placed in liquid nitrogen vapour (−80 to −100 °C) and after 25 min plunged into the liquid nitrogen and stored at −196 °C for at least 5 days. The selected straws were individually thawed in a 38 °C water bath for 30 s prior to post-freezing analysis. Motility indicators were assessed at 0, 60, 120, and 180 min after thawing. Parametric test was used for analysis; the measured indicators were total motility, progressive motility, curvilinear velocity, straightness, and average-path velocity. In this study, the best results were reached in samples diluted into a concentration of 1,000 × 106 in ml, regardless of the concentrations of glycerol.
Determination of African swine fever virus viability in meat during long-term storage and sous-vide cooking using cell culture and real-time PCR combined with palladium compound pre-treatment methods
Authors: Krzyžánková Miroslava , Prodělalová Jana , Krásna Magdaléna , Vašíčková Petra
Published: February 2023

African swine fever virus is the causative agent of an acute and highly contagious disease affecting domestic and wild members of the family Suidae. The virus can be transmitted by direct contact among infected animals or via a contaminated environment or feed. Since the contaminated meat or products thereof have been characterised as the most probable vehicle in several outbreaks, the aim of the present study was to define viability of the virus in meat under conditions of freezing and chilling (−25 °C and 6 °C) and low temperature cooking (55 °C for 2.5 h and for 1 h). Two independent methods were employed; cell culture as a reference and real-time polymerase chain reaction combined with palladium compound (BB-PdCl2 and PdCl2COD) pre-treatment as an alternative method. Obtained results demonstrated a minimal decrease in the infectious virus titre during storage at −25 °C, and a remaining amount of viruses in meat stored at 6 °C for 14 months that can cause a disease after ingestion. The results obtained by both methods applied on the samples corresponded to each other. In contrast, results related to the virus’ persistence in thermal-treated meat indicated much lower stability than previously thought; infectious viruses were not detected by infectivity assay after the treatment at 55 °C for 1 h. The observed difference of one order of magnitude of virus detected using palladium compound pre-treatment suggests presence of intact rather than infectious viruses. A better suitability of PdCl2COD compared to BB-PdCl2 pre-treatment was demonstrated.
The effect of conazoles on reproductive organs structure and function – a review
Authors: Maretta Milan , Marettová Elena , Legáth Jaroslav
Published: February 2023

Conazoles are azole antifungals used in agricultural and pharmaceutical products. Exposure to conazole fungicides leads to several toxic endpoints, including reproductive and endocrine. The results of animal experiments have shown that various conazole fungicides at high doses affect the structure and functions of reproductive organs. In males, adverse effects of conazole fungicides are manifested in the testes, prostate, sperm viability, fertility and sexual behaviour. Reduced testis weight, testis atrophy and reduced or absent sperm production were frequently observed. In female genitalia, structural changes in the ovaries and uterus have been observed. The extent of the changes depends on the dose and duration of treatment. Triazoles affected the expression of multiple genes involved in steroid hormone metabolism and modulate enzyme activity of multiple cytochrome P450 (CYP) and other metabolic enzymes in mammalian liver and other tissues. Conazole fungicides act as endocrine disruptors. Conazoles have been reported to reduce oestradiol and testosterone production and to increase progesterone concentration, indicating the inhibition of enzymes involved in the conversion of progesterone to testosterone. The reproductive effects are consistent with impairment of testosterone homeostasis. The disruption in steroid homeostasis is a common mode of action, leading to abnormal reproductive development and diminished reproductive function. At high doses, azole fungicides affect reproductive organs and fertility in several species.
Effect of Tarantula cubensis alcoholic extract on tumour pathways in azoxymethane-induced colorectal cancer in rats
Authors: Akcakavak Gokhan , Ozdemır Ozgur
Published: February 2023

The aim of this study was to determine the effects of Tarantula cubensis alcoholic extract (TCAE) on tumour development pathways in azoxymethane (AOM)-induced colorectal cancer in rats by molecular methods. Eighteen paraffin-embedded intestinal tissues, six from each group, were studied in the healthy control (C), cancer control (CC), cancer + TCAE (C-TCAE) groups. Sections of 5 µm thickness were taken from the paraffin blocks and submitted to staining with haematoxylin-eosin. In the histopathological examination, the number of crypts forming aberrant crypt foci (ACF) and the degree of dysplasia in the crypts were scored. Real-time PCR analysis was completed to determine β-catenin, KRAS (Kirsten rat sarcoma virus), APC (adenomatous polyposis coli) and P53 expressions on samples from each paraffin block. The grading scores of the number of crypts forming ACF and dysplasia in the crypts showed an evident decrease in the C-TCAE group in comparison to the CC group (P < 0.05). In real-time PCR analysis, mRNA expression levels of P53 (P > 0.05) and APC (P < 0.001) genes were found to be increased in the C-TCAE group according to the CC group. The expression levels of KRAS (P < 0.01) and β-catenin (P < 0.005) mRNA were found significantly decreased in the C-TCAE group. In conclusion, the effects of TCAE on AOM-induced colorectal cancer (CRC) in rats were evaluated molecularly; TCAE was found to modulate some changes in CRC developmental pathways, inhibiting tumour development and proliferation, and stimulating non-mutagenic tumour suppressor genes. Thus, it can be stated that TCAE is an effective chemopreventive agent.
A mathematical model for vaccine cold chain network design considering social sustainability
Authors: YILDIZ Nur Hivda , AKTAŞ Nadide , DEMİREL Neslihan
Published: February 2023

Breakages that may occur in the cold chain cause serious economic, environmental, and social costs, as well as a substantial risk for human and public health. Therefore, it is necessary to design an effective, robust, and strong vaccine cold chain network. Sustainable Development Goal 3 titled “Good Health and Well Being” emphasizes children's health and specifies reducing the mortality rate for under five ages. In this study, we consider the Expanded Programme on Immunization (EPI) vaccine cold chain in Türkiye and develop a linear programming model for a multi-product, multi-period, multi-stage vaccine cold chain network in light of Sustainable Development Goal 3. The study aims to maximize fully immunized children for up to five years and propose a framework for a vaccine cold chain network design. The proposed model is applied to a real case. Finally, various scenario analyzes are applied to show the results of the model under different conditions.
SPATIALITY AND TEMPORALITY OF ARTISTIC MEANING
Authors:   Russian State University for the Humanities, Podkovyrin Yuri V. ,   Moscow University for Industry and Finance “Synergy”
Published: February 2023

The article studies how the spatial and temporal characteristics of the world in a literary work are determined by the specific updating of artistic meaning. The specifics of the artistic meaning in the article are described using the concept of incarnation (embodiment). Using the example of the analysis of texts by A.E. Kruchenykh and M.Y. Lermontov, the author of the article shows how space and time are comprehended in the horizons of the heroes (in the internal semantic dimension of the work) and in the horizons of the author and recipients (in the external – aesthetic – semantic dimension of the text). The author of the article points out a number of significant differences between the semantics of space and time in the life and artistic contexts of comprehension. Characteristics of the vital understanding of space and time: 1) space and time are comprehended teleologically; 2) space and time semantically articulate a private life situation; 3) space and time are the coordinates of the comprehending relationship to the world. Characteristics of artistic understanding of space and time: 1) space and time are conceptualized ontologically; 2) space and time semantically articulate the whole of the characters’ lives; 3) space and time are the coordinates of the location of the heroes’ being as an incarnation of their (being) meaning
“WE SHOULD NOT PREVENT PEOPLE FROM GOING CRAZY”. MEDICAL, SOCIAL AND ARTISTIC DISCOURSES IN A.P. CHEKHOV’S “WARD NO. 6” AND “THE BLACK MONK”
Authors:   Russian State University for the Humanities, Odesskaya Margarita M.
Published: February 2023

The focus of our attention is Chekhov’s attitude to the institute of psychiatry as а part of Russian social system at the end of the 19th century. “Ward No. 6” is an invaluable material on the history of social medicine, comparable with the few documentary evidence of zemstvo (the county) doctors about the state of psychiatry in the Russian province of the late nineteenth century. The story “The Black Monk” draws increasing attention to the discussion around the topic of genius and madness, which received a new impetus in the fin de siècle era.
GRAMMATICAL AND PSYCHOLOGICAL READING OF PLATONOV’S “SHARMANKA (BARREL ORGAN)”
Authors:   Russian State University for the humanities, Myasnikov Elisei I.
Published: February 2023

The article deals with Andrei Platonov’s play “Sharmanka”. Its analysis shows how the author’s original and hidden language relates to the meaning of the text and to the author’s life. The play is also considered in the context of the poetics of the writer’s works close in time: the general tendency of thought, invariance of details and themes; different combinations of motifs and development of some leitmotifs are revealed. The method used is hermeneutics, as it is defined by Friedrich Schleiermacher – the art of understanding and interpreting the text. The “grammatical” and the “psychological” sides in such analysis remain identical – they are not separated, but constantly touching and mutually percepting, like part and parcel in a hermeneutic circle. First of all, that allows to approach the interpretation of difficult parts through the prism of the author’s life, thereby giving them a reasonable and convincing explanation; and secondly, to call “Sharmanka” partly an autobiographical work. Thus, the article studies the originality of Platonov’s language, its connection with the realities of Soviet times in the 20s and 30s; the intersection of the plot with important events in the writer’s life, such as the repudiation of the literary community, in particular his patron and comrade Alexander Fadeev; as well as the place of “Sharmanka” in the creative legacy of Andrei Platonov.
“WHAT THE HELL ARE WOLVES?” VYSOTSKY’S WORD IN “SHEEP HUNT” BY BORIS BELOKUROV (USOV)
Authors:   Russian State University for the Humanities, Domanskii Yuri V.
Published: February 2023

The article deals with the reference to the song by Vladimir Vysotsky “Hunting for wolves” in the text of Boris Belokurov (Usov) “Hunting for sheep”. The conclusion is made about the specific role of someone else’s word in the strong positions of the text – in the title, refrain, final verse, on the basis of which the author’s attitude is also characterized.
FINANCIAL AND CREDIT MECHANISM OF INNOVATION IN THE DEVELOPMENT OF REGIONAL BANKING
Authors: Slepakov Sergey , Magomaeva Leyla
Published: February 2023

Modern banking today is characterized not only by the entry into the market of new banking products, but by a significant complication of innovative tools that form a single financial and credit mechanism in the regions of the Russian Federation. Innovative activities cover various areas of the regional economy, being an integral part of modern banking, which has experienced a massive decline over the past seven years. The publication examines the reasons for the regional expansion of large, systemically important banks in the regions of the Russian Federation, substantiates the factors influencing the development of innovative technologies and discloses options for their successful implementation. The authors define innovative activity as the main condition for creating a stable demand for banking services in the regions in the face of fierce competition from the backbone financial institutions. The authors proposes fundamentally new forms of innovation entering the regional market through new integration associations: a regional credit and financial union; the bank for regional innovative cooperation and the fund for the development of banking and non-banking innovations, created in the form of non-profit organizations of regional significance. The targeted development of innovations in the banking industry is defined by the author as an opportunity for the successful functioning of the regional economy, as well as a new direction for the development of the financial and credit mechanism in the regions.
Types of rural settlements
Authors: Semenov Aleksandr
Published: February 2023

The article considers various approaches to the classification of rural settlements. This problem is important for planning the placement of social infrastructure facilities. Adhering to the typification of rural settlements of Rosstat by the number of living population, it is shown that small settlements with a population of 500-999 people are the most widespread. and 1000-1999 people. (21,8%). It is necessary to increase the provision of these settlements with social infrastructure facilities in order to reduce the compression of small settlements of this type.
Analysis of Student Ability in Using the AutoCAD Program in Civil Engineering Study Program Faculty of Engineering University Muhammadiyah of Aceh
Authors: Dama Yanti Ira , Maimunah  , Yeni Manovri
Published: February 2023

Every world of business and world of work (WBWW) needs human resources who can master and learn science and technology, which are continuously transforming. Civil engineering jobs include designing, constructing, maintaining, and repairing buildings. Auto Computer Aided Design (AutoCAD) technology software is very useful for civil engineering work when designing buildings. All WBWW in the field of civil engineering uses AutoCAD software when designing engineering, so human resources working in this field must be able to master AutoCAD software. On this basis, graduates of civil engineering are required to be able to master and operate application programs in the field of engineering. In the field of construction, human resources who are proficient in using AutoCAD are much needed. The Faculty of Engineering (FT) at the University Muhammadiyah of Aceh (UNMUHA) implements the use of AutoCAD in its curriculum. AutoCAD is one of the tools that supports the skills and development of the Civil Buildings Drawing (CBD) II Course. AutoCAD is an application program used for drawing, designing drawings, and testing materials. This research is to assess the frequency of the levels of mastery, skill, motivation, and discipline of Civil Engineering Study Program students at FT UNMUHA. The sampling technique used was purposive sampling, which is a sampling technique with the consideration that the respondents in this study were students of the Civil Engineering Study Program at FT UNMUHA who were active in the Even Semester of the 2021-2022 Academic Year and who programmed CBD II Course in their Study Plan Card (SPC), totaling 74 respondents. The results of this study indicate that students of the Civil Engineering Study Program at FT UNMUHA have high levels of mastery, interest, motivation, and discipline in completing drawing assignments using the AutoCAD application in the CBD II Course in the even semester of the 2021–2022 academic year.