bluuebunny/crossref_metadata_2025 huggingface dataset:
Combined Effects of Straw Return with Nitrogen Fertilizer on Ion Balance, Photosynthetic Characteristics, Leaf Water Status and Rice Yield in Saline-sodic Paddy Fields
Authors: Dang Kun , Ran Cheng , Tian Hao , Gao Dapeng , Mu Jinmeng , Zhang Zhenyu , Geng Yanqiu , Zhang Qiang , Shao Xiwen , Guo Liying
Published: March 2023

Aims salinisation severely limits crop growth and yield. In recent years, the effect of nitrogen fertilisation and different management practices on the mitigation of saline-sodic stress in crops has been less studied. Therefore, we conducted a three-year field experiment in Jilin Province, China, to investigate the effects of combined straw and nitrogen fertilizer application on the physiological and photosynthetic characteristics of rice in saline-sodic paddy fields.
Methods The experiment was designed as a split-zone trial, with straw (S) as the main zone and nitrogen fertilizer (N) as the secondary zone. The amount of straw returned was 0 t ha-1 (B) and 7 t ha-1 (T). Nitrogen treatments of 0, 150, 250 and 350 kg ha-1 were recorded as N0, N1, N2 and N3, and each treatment was repeated three times.
Results Straw combined with nitrogen fertilizer can effectively reduce the Na+/K+ value, malondialdehyde content and relative electric leakage of rice leaves in salt-alkali soil, and ensure the integrity of cell membrane. At the same time, the leaf water potential, relative water content and chlorophyll content were increased, which promoted rice photosynthesis and improved rice yield. In addition, it was found that straw combined with nitrogen fertilizer had the greatest positive effect on rice yield at 250kg ha-1.
Conclusions Straw combined with nitrogen fertilizer can improve the physiological and photosynthetic characteristics of rice in saline-alkali paddy field and provide a theoretical basis for rice yield increase in this area
Sero-prevalence of hepatitis viral infections among sanitary workers Across the Worldwide: Meta-Analysis and Systematic Review
Authors: Tolera Sina Temesgen , Alemu Fekade Ketema , Gawo Abreham Geremew , Mengistu Dechasa Adere , Temesgen Liku Muche , Sintie Tamagnu
Published: March 2023

Background: Sanitary workers are the possibility of have hepatitis viral infections due their working conditions. Thus, the aim of the review was to estimate the pooled sero-prevalence occupational related hepatitis viral infection among sanitary workers across the world.
Methods: PRISMA and PICOS were used flow diagram and review questions, respectively. Four databases other methods were used published articles from 2000 to 2022. Boolean logic (AND, OR), MeSH, and keywords were used: (Occupation *OR Job *OR Work) AND (Hepatitis Infection A *OR B *OR C *OR E) AND (Solid waste collectors [SWCs] *OR Street sweepers [SS] *OR Sewage workers [STW] *OR health facilities cleaners [HCFC) AND (Countries). CMA software used for data analysis (95%CI)
Results: A total of 178 studies were identified studies, a total of 25 studies were included from eleven countries. Of these, from developed (n=7 ) and developing countries (n=4). From total of sanitary workers (N= 7,945), 5951(74%), 1609 (21%) and 385 (5%) were STW, SWCs and SS, respectively. The overall pooled Sero-prevalence of HAV infection among sanitary workers across the world was 56.7% (95%CI: 0.44-0.69; p-value =0.32). While, 22.6% (95%CI: 0.10-0.44; p-value=0.01), 22.8% (95%CI: 0.10-0.45; p-value=0.02) and 33.1% (95%CI: 0.18-0.54; p-value=0.10) for HBV, HCV and HEV, respectively
Conclusion: The current pooled prevalence concluded that sanitary workers are at the risk of occupational related hepatitis viral infections that need governmental policies amendment and other efforts to mitigate these risks.
Effects of Febuxostat on Markers of Endothelial Dysfunction and Renal Progression in Patients with Chronic Kidney Disease
Authors: Nata Naowanit , Ninwisut Nanthawut , Inkong Pitchamon , Supasyndh Ouppatham , Satirapoj Bancha
Published: March 2023

Background

Hyperuricemia relates to chronic kidney disease (CKD) progression and impaired endothelial function. Febuxostat is potent and effective for decreasing serum uric acid levels. Information for the effect of febuxostat treatment on markers of endothelial dysfunction and renal injury in patients with CKD is limited.

Methods

A total of 84 CKD stage III-IV patients with asymptomatic hyperuricemia were randomly assigned to either the febuxostat (40 mg/day, N = 42) or the matching control (N = 42) for 8 weeks. Serum asymmetric dimethylarginine (ADMA), estimated glomerular filtration rate (eGFR), urine albumin, high sensitivity C-reactive protein (hs-CRP), ankle brachial index (ABI) and serum uric acid were measured at baseline and at the end of study.

Results

Febuxostat administration significantly reduced the serum uric acid concentration in patients with CKD when compared with control [-3.40 (95% CI -4.19 to -2.62) vs. -0.35 (95% CI -0.76 to 0.06) mg/dL; P < 0.001, respectively). No significant difference in the changes in serum ADMA, hs-CRP, eGFR and albuminuria was identified between the two groups. Subgroup analysis in patients with decline serum uric acid after febuxostat, the estimated GFR change between the febuxostat and the control group was significant difference at 8 weeks (2.01 (95%CI 0.31 to 3.7) vs. 0.04 (95%CI -1.52 to 1.61) mL/min/1.73 m2; P = 0.030, respectively). Adverse events specific to febuxostat were not observed.

Conclusion

Febuxostat effectively reduced serum uric acid in the population of CKD without improvement of endothelial dysfunction. It was able to preserve renal function in subgroup CKD patients with lower serum uric acid level after treatment.
Trial registration: Thai Clinical Trials, TCTR20210224005: 24/022021 http://www.thaiclinicaltrials.org/show/TCTR20210224005
Clinical characteristics of under-triaged elderly patients in the emergency department: a Korea public hospital observational study
Authors: Seo Yon Hee , Jang Kyeongmin
Published: March 2023

BackgroundElderly patients are more likely to be undertriaged because they often suffer from multiple diseases and complain of non-specific symptoms. Therefore, it is necessary to identify the characteristics of undertriaged elderly patients in emergency departments (EDs).MethodsThis descriptive study retrospectively reviewed and analyzed the electronic medical records of elderly patients who visited the ED of a general hospital in Seoul between January and December 2019.ResultsApproximately 29% (n = 4,823) of elderly patients who visited the ED during the study period were classified as CTAS level 4 or 5, and approximately 8% (n = 397) were undertriaged. Approximately 73% (n = 288) of patients were hospitalized after visiting the ED. The characteristics of the undertriaged elderly patients were nervous system symptoms such as dizziness and headache (28.8%), cardiopulmonary symptoms such as chest discomfort, palpitations, and abdominal pain (28.4%), head trauma (12.8%), and respiratory symptoms such as cough and dyspnea (12.5%).ConclusionED triage nurses should carefully triage elderly patients because their chief complaints can be non-specific. In particular, when elderly patients visit the ED, dizziness, abnormal pain, chest discomfort, palpitations, and head trauma can occur in intensive care units, so they must be carefully classified.
Effectiveness of telehealth in preventive care: A study protocol for a randomised controlled trial of tele- exercise programme involving elderly with possible sarcopenia or at risk of fall
Authors: CHAN Karly O. W. , YUEN Peter P.M. , FONG Ben Y.F. , LAW Vincent T.S. , NG Fowie S.F. , FUNG Wilson C.P. , NG Tommy K.C. , CHEUNG I. S.
Published: March 2023

Background

Continuous loss of muscle mass and strength are the consequences of the ageing process, which increase the risk of falls among older adults. Falls can lead to severe consequences such as bone fractures and hampered physical and psychological well-being. Regular exercise is the key to reversing muscle atrophy and relieving sarcopenia. However, the frailty of the elderly and the recent COVID-19 pandemic may affect their confidence to leave home to attend classes in the community. A feasible and effective alternative should be explored.

Methods

The primary objective is to evaluate the effectiveness of tele-exercise (TE) in relation to physical functioning and exercise adherence among the community-dwelling elderly at risk of falls in comparison with a community-based group (CB). The secondary objective includes evaluating the elderly's experience with tele-exercise, emphasizing their psychological welfare, social well-being, and acceptance of the telehealth approach. The design, conduct, and report follow the SPIRIT guidelines (Standard Protocol Items: recommended items to address in a Clinical Trial Protocol and Related Documents). The elderly will be recruited from 10 local community centres in Hong Kong and randomly allocated into two groups. All participants will attend the exercise training 3 days per week for 3 months but the mode of delivery will differ, either online as the tele-exercise group (TE) or face-to-face as the community-based group (CB). The outcome measures include muscle strength, physical function, exercise adherence and dropout rate, psychological and social well-being will be assessed at the baseline, and the 3rd, 6th and 12th month. Some participants will be invited to attend focus group interviews to evaluate their overall experience of the tele-exercise training.

Discussion

Tele-exercise reduces the barriers to exercise, such as time constraints, inaccessibility to facilities, and the fear of frail elderly persons leaving their home. Promoting an online home-based exercise programme for the elderly can encourage them to engage in regular physical activity and increase their exercise adherence even when remaining at home. The use of telehealth can potentially result in savings in cost and time. The final findings will provide insights on delivering exercise via telehealth to the elderly and propose an exercise delivery and maintenance model for future practice.
Trial registration: Chinese Clinical Trial Registry (http://www.chictr.org.cn/searchproj.aspx), registration number: ChiCTR2200063370. Registered on 5 September 2022
Artificial Intelligence and Automatic Recognition application in B2C E-commerce Platform Consumer Behavior Recognition
Authors: Xie Tian
Published: March 2023

One obvious development of science and technology in people's life is the development of e-commerce. Artificial intelligence technology is now inseparable from human society, and artificial technology and human society are each other to promote progress. Voice is the carrier of language, and voice recognition is actually the conversion of voice signals into symbols that can be recognized by the system. This not only improves the efficiency and accuracy of recognition, but also converts a variety of different languages into a universal symbol so that it can be recognized by a computer and its meaning can be understood. The development of e-commerce has also experienced a certain process, from the beginning to carry out information exchange with the help of the network, to the later application of artificial intelligence and voice recognition technology, to give consumers more experience. Under this development trend, B2C e-commerce has also been greatly promoted. However, there are still many B2C e-commerce which retain the traditional business model and cannot make good use of big data. Therefore, this paper analyzes the current situation of B2C e-commerce platform and introduces artificial intelligence technology into consumer behavior recognition. Analyze the urgent needs of consumer behavior recognition. In order to be able to develop B2C e-commerce companies, it is necessary to help them find potential customers. Based on the idea of data mining and a variety of methods, this article effectively suggests a set of consumer behavior recognition models to help companies find consumers quickly.
Case report：Treatment of subacute right ventricular apical perforation caused by ventricular electrode with intermittent slow and gradual traction
Authors: Yu Wei , Gu Xiang , Zhu Ye
Published: March 2023

Objective
We report a rare and severe case of subacute right ventricular apical myocardial perforation caused by ventricular electrode. Due to the lack of clear guidance, it is a great challenge for clinical diagnosis and treatment.
Case introduction:
A 78-year-old slim and weak woman underwent implantation of dual chamber permanent pacemaker to treat sick sinus syndrome 2 weeks ago. The atrial electrode was located in the right atrial appendage, and the ventricular electrode was located in the right ventricular apex of the lower septum. One week after the operation, chest tightness occurred, the pacemaker interrogation found that the ventricular electrode was not pacing, and echocardiography suggested that the right ventricular electrode was perforating the pericardium. With the guidance of Digital Substraction Angiography(DSA)and echocardiography, the patients' symptoms were relieved after surgical removal of the right ventricular electrode slowly. One week after operation, no pericardial effusion was found, and cardiac function was normal.
Conclusion
This case emphasizes the importance of meticulous technology in the process of electrode adjustment/removal in patients with right ventricular myocardial perforation caused by pacemaker electrode. Also, multidisciplinary joint diagnosis, as well as immediate and timely treatment of critically ill patients are vital.
Treatment of 5q-spinal muscular atrophy with nusinersen in Southern China: A single center retrospective study
Authors: Jiang Minyan , Liang Cuili , Zhang Yani , Zheng Kelu , Xu Kaishou , He Lu , Tao Jianping , Wu Weizhe , Zheng Ruidan , Rao Min , Zhang Wen , Liu Li
Published: March 2023

Nusinersen is the first approved disease-modifing therapy for all 5q-spinal muscular atrophy patients regardless of age or disease severity. In 2019, nusinersen treatment was approved by China Food and Drug Administration. Here, we first present the results of nusinersen treatment in Southern China. We analyzed clinical and laboratory data from 45 5q-spinal muscular atrophy patients between December 2019 and May 2022. Nine patients with 5q-spinal muscular atrophy type 1, 22 patients with type 2 and 14 patients with type 3 were enrolled. Mean age receiving therapy was 51 months. The mutational analysis revealed 3 SMN2 gene copies in the majority of patients (80.0%). Two and 4 copies were found in 4.4% and 15.6%. Total 230 nusinersen injections were performed. 98% (44/45) patients improved or remained stabilized, and 2.0% (1/45) worsened on motor scales during the follow-up. Over 60% (27/44) patients had gained a responder rate (improvement ≥ 4 points) after 4 doses injection in functional test. Nusinersen was well tolerated. But there were still 44.4% patients suffering respiratory tract infection during therapy. In conclusion, our data indicates that nusinersen treatment is safety and effective in motor function recovery for many Chinese 5q-spinal muscular atrophy pediatric patients, but the improvement of respiratory function is not obvious, which needs further assessment.
Whitham modulation theory and periodic solutions for the fifth-order nonlinear Schrödinger equation in the Heisenberg ferromagnetic spin chain
Authors: Zhang Yan , Hao Hui-Qin
Published: March 2023

In this paper, we investigate the periodic solutions and Whitham modulation theory for the fifthorder nonlinear Schrödinger equation, which can describe the one-dimensional anisotropic Heisenberg ferromagnetic spin chain. First, we introduce the principle of the finite-gap integration method. Then, we discuss the single-phase periodic solutions and their degenerate forms in two limit cases. In addition, we analyze the influence of higher-order term parameters on the propagation of periodic solutions and solitons. Further, we derive the single-phase Whitham modulation equation for the fifth-order nonlinear Schr¨odinger equation. Moreover, we systematically derive the two-phase periodic solutions and the corresponding Whitham modulation equations.
Cross-lagged analysis of the relationship between risk perception, physical activity, and adolescent mental health
Authors: Li Siyuan , Wang Ying
Published: March 2023

Background
Anxiety symptoms were prevalent in teenagers during the new coronavirus pandemic at 31% and depression symptoms were at 34%, both significantly higher than they were before the pandemic, according to research on global adolescent mood disorders during the epidemic. It is unclear, nevertheless, if physical activity still promotes mental health given the perceived danger of sickness, even though it has been demonstrated to be useful in reducing teenage mental health issues. Therefore, this study looked into the relationship between teenage mental health, risk perception, and physical activity.
Methods
In December 2022 and January 2023, two surveys were given to the same pupils in five high schools. During the New Crown pandemic, the risk perception scores, physical activity levels, and mental health of adolescents were examined in the study N=344.
Results
For adolescents' risk perceptions, there were significant gender differences (P＜0.01), with gender difference effects of 0.255 (d = 0.416) and 0.195 (d = 0.402) for the two measurements, respectively. For mental health, there were gender differences, with gender difference effects of 0.159 (d = 0.262) and 0.179 (d = 0.278) for the two measurements. The levels of risk perception, physical activity, and teenage mental health met persistent connections across months with contemporaneous correlations, however gender differences in physical activity levels were not significant (p > 0.05); Contrarily, in the cross-lagged study, males had higher levels of physical activity and mental health than females, and teenagers' risk perception was higher. Physical activity and mental health were both predicted by T1 ( values of 0.28, 0.19, and P＜0.01, respectively). Risk perception T1 physical exercise T2 mental health T2 (mediating value impact of 0.012, the Z value of 0.112), as well as the indirect effect of Bootstrap, were all able to predict mental health T2 (β= 0.33, P ＜0.01). Indicating a substantial mediating role for physical activity between risk perception and mental health is the 95% CI, not the 0 value from this pathway.
Conclusion
Raising awareness of physical activity among adolescents according to gender is important for improving mental health and there is a longitudinal causal relationship between perceived risk of disease, physical activity, and mental health among adolescents, suggesting that physical activity still has a role in mental health in the presence of risk perception.
Clocking effect on the internal flow field and pressure fluctuation of PAT based on entropy production theory
Authors: Zhang Yang , Qi Shuaiwei , Jiang Wei , Xu Lei , Wang Yuchuan , Chen Diyi
Published: March 2023

The high-quality development of energy is closely related to the efficiency of energy utilization, and improving the hydraulic performance of the pump as turbine ( PAT ) has become increasingly important. In order to explore the influence mechanism of the clocking effect on the hydraulic performance of the pump as turbine, the energy loss analysis method based on entropy production theory is used to explore its hydraulic performance and internal flow characteristics. The results show that the clocking effect has an impact on the pump as turbine at all flow rates. Compared to the initial scheme, the efficiency of the C6 scheme is improved by 1.60% and 1.93% at the design and overload conditions. With the increase of the guide vane clocking angle, the flow field near the tongue and guide vane is improved, and the loss of the vortices in the volute is weakened, which in turn improves the hydraulic performance of the PAT. The effect of the clocking effect on pressure pulsation at low flow rates is more significant, and the C6 scheme has the best pressure pulsation characteristics. The research in this paper reveals the cause of the clocking effect, which can provide a theoretical basis for the hydraulic optimization of the pump as turbine.
Mining local exome and HLA data to characterize actionable pharmacogenetic variants in Saudi Arabia
Authors: Abouelhoda Mohamed , Almuqati Noura , Goach Ahmad Abu , Alfuraih Firas , Maddirevula Sateesh , Alkuraya Fowzan
Published: March 2023

Pharmacogenomics (PGX) is a promising field of precision medicine where efficacy of drugs is maximized while side effects are minimized for individual patients. Knowledge of the frequency of PGX-relevant variants in the local population is a pre-requisite to informed policy making. Unfortunately, such knowledge is largely lacking from the Middle East. Here, we describe the use of a large clinical exome database (n=13,473) and HLA haplotypes (n=64,737) from Saudi Arabia, one of the largest countries in the Middle East, to ascertain allele frequencies of known PGX variants. In addition, we queried another exome database (n=816) of well-phenotyped research subjects from Saudi Arabia to discover novel PGX candidate variants. Although our results show that only 26% (63/242) of class 1A/1B PharmGKB variants were identified, we estimate that 99.57% of the local population have at least one PGX variant (class 1A/1B PharmGKB). This translates to a minimum estimated impact of 9% of medications dispensed by our medical center annually. We also highlight the contribution of rare variants where 71% of the genes devoid of common PGX variants had at least one potentially deleterious rare variant. Thus, we show that approaches that go beyond the use of commercial PGX kits that have been optimized for other populations should be implemented to ensure universal and equitable access of all members of the local population to personalized prescription practices.
Application of embedded voice and digital forensics system in financial cost management
Authors: Lin Yang
Published: March 2023

This article first describes the embedded voice processing process, and uses the two-door restriction method for endpoint detection. Next, the wavelet+MFCC algorithm is proposed. The Fourier transform will replace it with ripple. The disadvantage of the ripple is that the size of the Fourier transform window cannot move with frequency. On this basis, the overall goal of the system is proposed, the overall structure is constructed, and the functions of the system are divided. Android mobile phone data collection technology has been extensively researched, including logical search, temporary access to permissions, JTAG search and ISP search. The design and implementation of the logical search engine based on root authority, the physical search engine based on Qualcomm processor, and the data analysis system have been completed, and the evidence collection of e-commerce applications has been completed. Based on the digital forensics system, this article studies and designs an Android device digital forensics system suitable for China's national conditions and laws from the three perspectives of data collection, analysis and storage. At the same time, brainstorming methods must be used between corporate financial management and cost management personnel. Finally, through research, scientifically construct the framework of the financial cost management system, distinguish the various requirements of the construction system, classify the importance, urgency, and feasibility of the requirements, establish the basic requirements and extension requirements, set the demand function to complete the schedule and Perform as planned. Through the research of embedded voice and digital forensics system, this paper applies it to the research of financial cost management, thereby promoting the development of enterprise financial management.
Propensity score-matched analysis of oncological and functional outcomes of submental island flap versus radial forearm free flap for oral cavity cancer reconstruction
Authors: Sittitrai Pichit , Ruenmarkkaew Donyarat , Kumkun Chananchida , Srivanitchap Chonticha
Published: March 2023

Background
The aim of this study is to compare the oncological and functional outcomes of the submental island flap versus the radial forearm free flap used for oral cavity cancer reconstruction after minimizing differences in baseline characteristics.
Methods
Propensity scores for each oral cavity cancer patients who underwent surgical resection and immediate reconstruction with a submental island flap or a radial forearm free flap with a flap size ≤ 60 cm2 between October 2008 and December 2021 were generated based on the likelihood of being selected given their baseline characteristics. Patients were matched using a 1:1 nearest-neighbor approach.
Results
The final matched-pair analysis included 51 patients in each group. The 5-year overall survival, disease-specific survival, and locoregional control rates were 70.1% and 64.8% (p = 0.612), 77.3% and 83.7% (p = 0.857), and 76.1% and 73.3% (p = 0.664), respectively, for the submental island flap group and the radial forearm free flap group. Speech and swallowing functions were comparable between groups. However, there were significantly lower rates of complication associated with both donor and recipient sites in the submental island flap group and also the duration of hospital stay and hospital costs were significantly lower in these patients. A subgroup analysis of patients in which the reconstruction was carried out using the submental island flap procedure revealed that the presence of clinically and pathologically positive level I lymph nodes did not affect survival or locoregional control rates.
Conclusions
Although this study was not randomized, the matched-pair analysis of surgically treated oral cavity cancer patients showed that submental island flap reconstruction is as effective as radial forearm free flap reconstruction with regard to oncological and functional outcomes with lower complication rates, hospital stay, and hospital costs. This flap can be safely and effectively performed in selected cases with clinically and pathologically positive level I lymph nodes.
A mathematical interpretation for outbreaks of bacterial meningitis under the effect of time-dependent transmission parameters
Authors: Türkün Can , Gölgeli Meltem , Atay Fatihcan Mehmet
Published: March 2023

We consider a SIR-type compartmental model divided into two age classes to explain the seasonal exacerbations of bacterial meningitis, especially among children outside of the meningitis belt. We describe the seasonal forcing through time-dependent transmission parameters that may represent the outbreak of the meningitis cases after the annual pilgrimage period (Hajj) or uncontrolled inflows of irregular immigrants. We present and analyze a mathematical model with time-dependent transmission. We consider not only periodic functions in the analysis but also general non-periodic transmission processes. We show that the long-time average values of transmission functions can be used as a stability marker of the equilibrium. Furthermore, we interpret the basic reproduction number in case of time-dependent transmission functions. Numerical simulations support and help visualize the theoretical results.
Mathematics Subject Classification (2020) 93A30 · 92D30 · 34A34
Assessment of Automated Threshold selection methods and Flood Frequency Analysis of Hydrological extremes.
Authors: Ghaleh Laleh Rezaei , Rezaie Hossein , Ghorbani Khalil
Published: March 2023

Flood Frequency Analysis (FFA) is a popular approach providing important information about the frequency of future extreme values. Employing this information can be very effective for better planning, design, and operation of flood protection defenses, which leads to more reliable watershed management. The present study, considering Haji-Ghoshan, Ghouchmaz, and Ghareh-Shour hydrometric stations of the Gorgan Roud River basin as the study area, examined the behavior of six different GPD parameter estimators using Monte-Carlo simulations, compares three automated threshold selection techniques based on POT and finally evaluates the performance of each threshold selection methods using NRMSE and relative index of agreement. The results indicate that in all stations the SE method provided smaller thresholds than other threshold selection techniques. Short tail distribution is provided for the normality of differences method in in Haji-Ghoshan and Ghouchmaz stations. The SE, MAX PV, and Cramer-von Mises/Kolmogorov-Smirnov methods provided the optimum thresholds based on\({r_d}\)and NRMSE in Haji-Ghoshan, Ghouchmaz and Ghareh-Shour stations, respectively.
Reanalysis of Linear Accelerator Use Factors for Shielding Calculations based on DICOM-RT
Authors: Choi Dong Hyeok , Ahn Sohyun , Park So Hyun , Kim Dong Wook , Ahn Woo Sang , Lee Rena , Kim Jin Sung
Published: March 2023

Our study reanalyzed the use factor of linear accelerators (LINACs) by using an in-house program based on Digital Imaging and Communications in Medicine radiation therapy (DICOM-RT). We took into account the impact of advancements and changes in treatment trends, including modality, technology, and radiation dose. The use factor was calculated for four LINACs in three hospitals and compared with that of the NCRP 151 report. We analyzed the results based on the treatment techniques and treatment sites for three-dimensional conformal radiation therapy (3D CRT) and intensity modulated radiation therapy or volumetric modulated arc therapy. Our findings revealed that the use factors obtained at 45° and 90° were 14.8% and 13.5% higher than those of the NCRP 151 report. In treatment rooms with a high 3D CRT ratio, the use factor at a specific angle differed by up to 14.6% relative to the NCRP 151 report value. Additionally, the use factors for different treatment sites, especially for breast and spinal treatments, were significantly different from those of the NCRP 151 report.
Delphi panel to obtain clinical consensus about using long-acting injectable antipsychotics to treat first-episode and early-phase schizophrenia: Treatment goals and approaches to functional recovery
Authors: Arango Celso , Fagiolini Andrea , Gorwood Philip , Kane John M. , Diaz-Mendoza Sergio , Sahota Navdeep , Correll Christoph U
Published: March 2023

Background
Schizophrenia is mostly a chronic disorder whose symptoms include psychosis, negative symptoms and cognitive dysfunction. Poor adherence is common and related relapse can impair outcomes. Long-acting injectable antipsychotics (LAIs) may promote treatment adherence and decrease the likelihood of relapse and rehospitalization. Using LAIs in first-episode psychosis (FEP) and early-phase (EP) schizophrenia patients could benefit them, yet LAIs have traditionally been reserved for chronic patients.
Methods
A three-step modified Delphi panel process was used to obtain expert consensus on using LAIs with FEP and EP schizophrenia patients. A literature review and input from a steering committee of five experts in psychiatry were used to develop statements about patient population, adverse event management, and functional recovery. Recruited Delphi process psychiatrists rated the extent of their agreement with the statements over three rounds (Round 1: paper survey, 1:1 interview; Rounds 2–3: email survey). Analysis rules determined whether a statement progressed to the next round and the level of agreement deemed consensus. Measures of central tendency (mode, mean) and variability (interquartile range) were reported back to help panelists assess their previous responses in the context of those of the overall group.
Results
The Delphi panelists were 17 psychiatrists experienced in treating schizophrenia with LAIs, practicing in seven countries (France, Italy, US, Germany, Spain, Denmark, UK). Panelists were presented with 73 statements spanning three categories: patient population; medication dosage, management, and adverse events; and functional recovery domains and assessment. Fifty-five statements achieved ≥ 80% agreement (considered consensus). Statements with low agreement (40%-79%) or very low agreement (< 39%) concerned initiating dosage in FEP and EP patients, and managing loss of efficacy and breakthrough episodes, reflecting current evidence gaps. The panel emphasized benefits of LAIs in FEP and EP patients, with consensus that LAIs can decrease the risk of relapse, rehospitalization, and functional dysfunction. The panel supported links between these benefits and multidimensional longer-term functional recovery beyond symptomatic remission.
Conclusions
Findings from this Delphi panel support the use of LAIs in FEP and EP schizophrenia patients regardless of disease severity, number of relapses, or social support status. Gaps in clinician knowledge make generating evidence on using LAIs in FEP and EP patients critical.
Virtualized Resource Provisioning for Hybrid Cloud Computing Services Using Optimal Data Analytics
Authors: G Sathish , KATIRAVAN JEEVAA
Published: March 2023

Resource Provisioning is the important method to offer cloud as services to the user. Nowadays cloud computing has multiple access and application levels. We need a hybrid and virtualized method to provide efficient resource provisioning method. In existing resources can be offered based on user request or availability. But current scenario we need any time access privilege based services offering systems. Also data analytics is another factor to analyse the data and make effective decision making approach. We propose an efficient virtualized dynamic resource provisioning method for cloud application and virtualized optimizer for topological cloud management. We prepare optimal data analytics method to predict the accuracy and performance of cloud access and resources. In this paper automated machine learning technique is applied to measure the temporal features and queuing results. In this case loads are distributed to server and optimize the cloud using service level agreement. Our research method can provide the result of time service analysis, accuracy index, performance factors and optimality value. Also our method can test over provisioning and energy consumption. We use CloudSim for simulating cloud environment and TensorFlow for testing accuracy using Deep belief network optimization.
Genotype-Degree of hemolysis Correlation in Hereditary Spherocytosis
Authors: Shi Yimeng , Li Yuan , Yang Xiawan , Li Xiaoxia , Peng Guangxin , Zhao Xin , Liu Xu , Zhao Yufei , Hu Jing , Hu Xiangrong , Zhang Baohang , Zhou Kang , Yang Yang , Xiong Youzhen , Li Jianping , Fan Huihui , Yang Wenrui , Ye Lei , Jing Liping , Zhang Li , Zhang Fengkui
Published: March 2023

Objective:To investigate the potential genotype-degree of hemolysis association in hereditary spherocytosis (HS).
Methods: 23 HS patients in our cohort all conducted next-generation sequencing (NGS) to detect erythrocyte membrane protein gene mutations and Levitt's carbon monoxide (CO) breath test to detect erythrocyte (RBC) lifespan. The data of RBC lifespan were statistically analyzed according to different mutation genes, types and sites.
Results: There were 8 ANK1,9 SPTB,5 SLC4A1 and 1 SPTA1 mutations in our cohort, and the median RBC lifespan of 23 HS patients was 14(8-48) days. The median RBC lifespan of patients with ANK1, SPTB and SLC4A1 mutations was 13(8-23), 13(8-48) and 14(12-39) days, with no statistically significant difference(P=0.618). The median RBC lifespan of patients with missense, splice and nonsense/insertion/deletion mutations was 16.5 (8-48), 14 (11-40) and 13(8,-20) days, respectively, with no statistical difference(P=0.514). The median RBC lifespan of patients with mutations located in the spectrin-binding domain and the non-spectrin-binding domain was 14(8-18) and 12.5(8-48) days, with no statistical difference(P=0.959). 25% of patients with mild hemolysis carried ANK1 or SPTA1 mutations and 75% carried SPTB or SLC4A1 mutations, while 46.7% of patients with severe hemolysis had ANK1 or SPTA1 mutations and 53.3% had SPTB or SLC4A1 mutations. The composition of mutated genes did not differ statistically between the two groups(P=0.400).
Conclusion: This is the first study focusing on the genotype-degree of hemolysis association in HS. Our findings indicate that there is no clear correlation between genotype and degree of hemolysis in HS.
Null Broadening Beamforming for Passive Sonar Based on Weighted Similarity Vector
Authors: Wang Yuhao , Zhang Zhenkai
Published: March 2023

Beamforming technology is very important for passive sonar to detect targets. However, the performance of beamformer is seriously degraded in practical applications due to the complex and changeable underwater environment. In this paper, a null broadening algorithm for passive sonar based on weighted similarity vector is proposed for underwater fast moving strong interference signals. First, The covariance matrix is reconstructed through the correlation between the steering vector and the subspace eigenvector, which is used to calculate the similarity vector. Then, the maximum power in the interference angle sector is used as the virtual interference source power to broaden the null trap in the angle sector. Next, the difference between the optimal weight vector and the similar vector is minimized, interference-plus-noise power constraints and norm constraints are added, and it is written as a quadratic constrained quadratic programming (QCQP) problem, which is converted into a convex optimization problem by using the semidefinite relaxation technique. Finally, the optimal solution is calculated by using eigen decomposition. The simulation results show that the algorithm can guarantee deep nulling and effectively suppress sidelobe height under various error conditions, which shows that the proposed algorithm has good suppression effect and strong robustness for fast strong interference.
Exact and Approximate Digraph Bandwidth
Authors: Jain Pallavi , Kanesh Lawqueen , Lochet Willian , Saurabh Saket , Sharma Roohani
Published: March 2023

Note: Please see pdf for full abstract with equations.
In this paper, we introduce a directed variant of the classical BANDWIDTH problem and study it from the view-point of moderately exponential time algorithms, both exactly and approximately. Motivated by the definitions of the directed variants of the classical CUTWIDTH and PATHWIDTH problems, we define DIAGRAPH BANDWIDTH as follows. Given a digraph D and an ordering σ of its vertices, the digraph bandwidth of σ with respect to D is equal to the maximum value of σ(v) − σ(u) over all arcs (u, v) of D going forward along σ (that is, when σ(u) < σ(v)). The DIAGRAPH BANDWIDTH problem takes as input a digraph D and asks to output an ordering with the minimum digraph bandwidth. The undirected BANDWIDTHeasily reduces to DIAGRAPH BANDWIDTH and thus, it immediately implies that DIAGRAPH BANDWIDTH is NP-hard. While an O⋆(n!)∗ time algorithm for the problem is trivial, the goal of this paper is to design algorithms for DIAGRAPH BANDWIDTH which have running times of the form 2O(n). In particular, we obtain the following results. Here, n and m denote the number of vertices and arcs of the input digraph D, respectively.
• DIAGRAPH BANDWIDTH can be solved in O⋆(3n · 2m) time. This result implies a 2O(n) time algorithm on sparse graphs, such as graphs of bounded average degree (planar graphs).
• Let G be the underlying undirected graph of the input digraph. If the treewidth of G is at most t, then DIAGRAPH BANDWIDTH can be solved in time O⋆(2n+(t+2) log n). This result implies a 2n+O(√ n log n) algorithm, for directed planar graphs and, in general, for the class of digraphs whose underlying undirected graph excludes some fixed graph H as a minor.
• DIAGRAPH BANDWIDTH can be solved in min{O∗(4n · bn),O∗(4n · 2b log b log n)} time, where b denotes the optimal digraph bandwidth of D. This allow us to deduce a 2O(n) algorithm in many cases, for example when b ≤ n / log2n.
• Finally, we give a (Single) Exponential Time Approximation Scheme for DIAGRAPH BANDWIDTH. In particular, we show that for any fixed real ϵ > 0, we can find an ordering whose digraph bandwidth is at most (1+ϵ) times the optimal digraph bandwidth, in time O∗(4n · (⌈4/ϵ⌉)n).
∗The O⋆ notation hides the polynomial factors in the instance size.
Target focus capture system based on enhancement learning and impedance variable structure control
Authors: Zhang Zhihuan , Hu Chao , Zhang Sheng
Published: March 2023

For the robotic detecting and grasping of the digestive tract, a cyber-physical system of focus capturing based on a physician's vision and the high-performance robot impedance control method are proposed in this study. The structure of the cyber-physical system for the focus information is given, which includes the physician, the network, the robot, and the digestive tract. The structure is controlled remotely by physicians through a 5G network, and is divided into two layers. The upper layer is mainly for physicians to capture the target of digestive tract focus through enhancement learning, and send instructions to the lower layer robot impedance control set and joint controller through space conversion and 5G network. In this way, the lower layer robot joint can quickly find the target of the digestive tract focus according to the instruction. At the same time, the optimal performance of target capturing, target trajectory processing of Akima, and time-varying nonlinear mapping between robot workspace and joint space are discussed. Finally, the Target Focus Capture system based on enhancement learning and new variable structure impedance control is first proposed for the Doctor-Robot system, and the simulation results show that the remote control method is feasible. In addition, it can be used for reference in COVID-19 prevention and control. At the same time, it is of great help to the examination and operation of unskilled professional physicians.
Balance Assessment in Selected Stages of Parkinson’s Disease Using Stock Exchange Indices
Authors: Wodarski Piotr , Jurkojć Jacek , Michalska Justyna , Kamieniarz Anna , Juras Grzegorz , Gzik Marek
Published: March 2023

Background
Balance disorders in patients diagnosed with Parkinson’s disease (PD) are associated with a change in balance-keeping strategy and reflex disorders which regulate the maintenance of vertical body posture. Center of foot pressure (COP) displacement signals were analyzed during quiet standing experiments to define such changes. The research aimed to apply stock exchange indices based on the trend change analyses to the assessment of a level of the Parkinson disease progression on the grounds of the analysis of the COP signals.
Methods
30 patients in two stages of PD, 40 elderly participants, and 20 individuals at a young age were studied. Each person was subjected to 3 measurements with open and closed eyes. A technical analysis of the COP displacement signal was performed, and the following quantities were determined: indices related to the number of trend changes (TCI), indices defining a mean time (TCI_dT), and mean displacement (TCI_dS) and mean velocity (TCI_dV) between such changes.
Results
The results indicate a higher TCI value for PD than for CG (p < 0.05). In the case of PD patients, there was also an increase in the TCI_dS value by 2–5 mm, which mainly contributed to the increase in TCI_dV. Statistically significant differences for the TCI_dT values occurred between all groups in which differences in the average COP velocity were noted.
Conclusions
The TCI and TCI_dV results obtained for the healthy participants enabled the development of indices supporting PD diagnostics. The causes of the TCI_dV changes in patients were determined, i.e., whether they resulted from an increase in the TCI_dT or TCI_dS between the moments of trend changes indicated by the developed algorithm. The developed methodology provides new information on the impact of PD on the strategy of maintaining balance, which was impossible to obtain using currently used analyses. The use of this method to differentiate the stage of PD requires further research.
Trial registration:
The conducted research is an observational study and does not include a health care intervention. Participants gave their consent to participate in the research and the procedure was approved by the Institutional Bioethics Committee.
A Novel Framework for Mobile Forensics Investigation Process
Authors: Moreb Mohammed , Salah Saeed , Amro Belal
Published: March 2023

Investigating digital evidence by gathering, examining, and maintaining evidence that was stored in smartphones has attracted tremendous attention and become a key part of digital forensics. The mobile forensics process aims to recover digital evidence from a mobile device in a way that will preserve the evidence in a forensically sound condition, this evidence might be used to prove to be a cybercriminal or a cybercrime victim. To do this, the mobile forensics process lifecycle must establish clear guidelines for safely capturing, isolating, transporting, storing, and proving digital evidence originating from mobile devices. There are unique aspects of the mobile forensics procedure that must be taken into account. It is imperative to adhere to proper techniques and norms in order for the testing of mobile devices to produce reliable results. In this paper, we develop a novel methodology for the mobile forensics process model lifecycle named Mobile Forensics Investigation Process Framework (MFIPF) which encompasses all the necessary stages and data sources used to construct the crime case. The developed framework contributes to identifying common concepts of mobile forensics through the development of the mobile forensics model that simplifies the examination process and enables forensics teams to capture and reuse specialized forensic knowledge. Furthermore, the paper provides a list of the most commonly used forensics tools and where can we use them in our proposed mobile forensic process model.
Chemical pancreatectomy in non-human primates ablates the acini and ducts and enhances beta-cell function
Authors: Kalsi Ranjeet S. , Kreger Alexander M. , Saleh Mohamed , Yoshida Shiho , Sharma Kartikeya , Fusco Joseph , Saloman Jami L. , Zhang Ting , Thomas Madison , Sehrawat Anuradha , Wang Yan , Reif Jason , Mills Juliana , Raad Sarah , Zengin Bugra , Gomez Ana , Singhi Aatur , Tadros Sameh , Slivka Adam , Esni Farzad , Prasadan Krishna , Gittes George
Published: March 2023

Chronic pancreatitis is a debilitating disease affecting millions worldwide. These patients suffer from bouts of severe pain that are minimally relieved by pain medications and may necessitate major surgeries with high morbidity and mortality. Previously, we demonstrated that “chemical pancreatectomy,” a pancreatic intraductal infusion of dilute acetic acid solution, ablated the exocrine pancreas while preserving the endocrine pancreas. Notably, chemical pancreatectomy resolved chronic inflammation, alleviated allodynia in the cerulein pancreatitis model, and improved glucose homeostasis. Herein, we extensively tested the feasibility of a chemical pancreatectomy in NHPs and validated our previously published pilot study. We did serial computed tomography (CT) scans of the abdomen and pelvis, analyzed dorsal root ganglia, measured serum enzymes, and performed histological and ultrastructural assessments and pancreatic endocrine function assays.  Based on serial CT scans, chemical pancreatectomy led to the loss of pancreatic volume. Immunohistochemistry and transmission electron microscopy demonstrated exocrine pancreatic ablation with endocrine islet preservation. Importantly, chemical pancreatectomy did not increase pro-nociceptive markers in harvested dorsal root ganglia. Also, chemical pancreatectomy improved insulin secretion to supranormal levels in vivo and in vitro. Thus, this study may provide a foundation for translating this procedure to patients with chronic pancreatitis or other conditions requiring a pancreatectomy.