bluuebunny/crossref_metadata_2025 huggingface dataset:
Biodynamic Lighting: Establishing Foundational Considerations for ‘Life-Centric’ Lighting
Authors: Dugar Amardeep M.
Published: January 2023

The term ‘biodynamic’ lighting is proposed as a term to capture the true aspiration of ‘life-centric’ lighting: good human and non-human outcomes for all life-sustaining behaviours on earth driven by good design for phototropism, phototaxis, photoperiodism and circadian entrainment. While future studies are necessary to consolidate this aspiration, it is clear that lighting has immediate potential to better support planetary health. As many aspects of animal, human and plantbehaviour and survival are being perturbed by widespread exposure to artificial light at night (ALAN), lighting professionals are in the middle, attempting to make design decisions that directly affect these life forms. This paper empowers readers with fundamental understandings of how light information is used by these life forms in a way crucial for development, growth and survival. The paper then provides a process for life-centric lighting design by drawing inspiration from an existing process for human-centric lighting design which can dovetail with decision-making processes that are within the workflow of lighting professionals. Holistic consideration of life-centric lighting design should look beyond altruism and romanticism by firmly rooting itself into pragmatism about long-term considerations for planetary health. Key references are consolidated and synthesized with goals of supporting knowledge translation into pragmatic lighting strategies in a manner useful for lighting professionals. While the scientific community remains sceptical about the term ‘biodynamic’ – which is argued to be developed through mysticism instead of scientific methodology – this paper counter argues that with appropriate use, the term has the potential to comprehensively capture this aspiration.
PENGEMBANGAN MODUL SENI MERANGKAI BUNGA TANGAN PENGANTIN (HAND BOUQUETE) (DITERAPKAN PADA MATA KULIAH SENI DEKORASI RUANG KHUSUS TATA RIAS)
Authors: - Ayu Lestari
Published: January 2023

Penelitian ini merupakan jenis penelitian dan pengembangan (Research and Development) yang menghasilkan pengembangan sebuah produk berupa Modul Pembelajaran Seni Merangkai Hand Bouquet Dasar untuk Dekorasi Pengantin yang digunakan sebagai media pembelajaran mahasiswa pada mata kuliah Seni Dekorasi Ruang Khusus Tata Rias, Program Studi Pendidikan Tata Rias, Fakultas Teknik, Universitas Negeri Jakarta.Modul Pembelajaran ini menggunakan model pengembangan Thiagarajan dengan model 4D, meliputi define, design, develop, dan dissemination. Pada tahap develop, peneliti melakukan validasi modul dan revisi modul kepada Diniwaty Abidin sebagai ahli materi, Cecep Kustandi, M.Pd sebagai ahli media, dan mahasiswa program studi Pendidikan Tata Rias Universitas Negeri Jakarta angkatan 2018 sebanyak 31 mahasiswa sebagai pengguna.Berdasarkan hasil penelitian, dapat dinyatakan bahwa modul pembelajaran ini telah layak untuk dijadikan sumber alternatif belajar pada mata kuliah Seni Dekorasi Ruang Khusus Tata Rias. Hal ini didukung dengan persentase hasil penilaian dari para ahli dan pengguna. Penilaian ahli materi mendapatkan persentase 87,09%, penilaian ahli media mendapatkan persentase 86,85% dan penilaian pengguna mendapatkan persentase 90,36% dari yang diharapkan 100%. Dengan demikian, media pembelajaran modul Seni Merangkai Hand Bouquet Dasar untuk Dekorasi Pengantin sudah memenuhi berbagai aspek dari syarat media pembelajaran dan dianggap sangat layak untuk dijadikan alternatif sumber belajar pada materi Seni Merangkai Hand Bouquet.
UJI COBA KELAYAKAN PEMANFAATAN BAHAN ALAM SEBAGAI PEWARNA PADA CAT KUKU
Authors: Restu Rizkya
Published: January 2023

Pewarna kuku cair atau cat kuku merupakan bahan berbentuk cair yang biasanyadigunakan untuk mewarnai dan mempercantik penampilan kuku. Tujuan dari penelitian iniadalah untuk melakukan uji coba pemanfaatan pada bahan alam untuk dijadikan cat kuku.Bahan alam yang digunakan di bedakan dengan 3 bahan yaitu, kulit buah naga merah,rimpang kunyit dan umbi bit. Metode penelitian ini menggunakan metode eksperimen.Dengan demikian hasil yang diperoleh dari kelayakan pewarna kuku oleh ahli farmasi yaitubahan alam 1 dan bahan alam 3 belum layak digunakan karena tidak memberikan warna danketercampuran bahan yang maksimal. Pewarna alami yang digunakan dalam sediaan pewarnakuku tidak dapat bercampur dengan baik sehingga terlihat gumpalan di dasar wadah sediaan.Pada bahan alam 2 sudah cukup layak untuk digunakan karena kunyit yang ditambahkandapat bercampur dengan baik dengan sediaan formulasi pewarna kuku sehingga dapatmemberikan warna yang baik setelah diaplikasikan. Namun, masih terlihat gumpalan di dasarwadah sediaan. Sedangkan hasil kuesioner, nilai kesukaan yang tertinggi pada indikatorbentuk atau tekstur yaitu bahan alam 2 (rimpang kunyit), indikator aroma pada bahan alam 1(buah naga) dan indikator warna pada bahan alam 2 (rimpang kunyit).
Pelatihan Keterampilan Wajah Pamgguh Penari Remo Di Sanggar Umbul Arum Jombang
Authors: Zepty Nia , Biyan Yesi Wilujeng
Published: January 2023

Tari remo merupakan kesenian tari tradisional yang asalnya ialah dari Jawa Timur. Tari ini awalnya berfungsi sebagai penyampai kisah yang isinya mengenai cerita pangeran yang sedang berada di peperangan, namun seiring dengan berkembangnya zaman, tarian itu sekarang berubah menjadi kesenian pertunjukan.Sanggar Umbul Arum Jombang ialah sanggar yang memfasilitasi anggota sanggar untuk belajar beragam tarian, dan satu diantaranya ialah tarian remo, namun pada pelaksanaannya ada masalah yang dialami oleh pemilik sanggar yakni mengenai tata rias, mereka tidak bisa melakukan penataan rias mereka sendiri sehingga mengharuskan mereka memanggil pihak luar. Penelitian ini bertujuan untuk memperoleh informasi terkait : 1) Keterlaksanaan pelatihan  merias wajah panggung penari remo di Sanggar Umbul Arum Jombang, 2) Aktivitas peserta pada pelatihan merias wajah panggung penari remo di Sanggar Umbul Arum Jombang, 3) Hasil keterampilan merias wajah panggung penari remo di Sanggar Umbul Arum Jombang, 4) Respon peserta pelatihan merias wajah panggung penari remo di Sanggar Umbul Arum Jombang. Penelitian ini berjenis pre-experimental design dengan rancangan penelitian one shot case study. Subyek penelitian ialah anggota Sanggar Umbul Arum Jombang yang jumlahnya ada 5 orang. Teknik pengumpulan data memakai observasi, tes dan angket. Hasil penelitian memperlihatkan bahwasannya keterlaksanaan pelatihan mendapat jumlah nilai rata-rata 4,52 (sangat baik), aktivitas peserta pelatihan mendapat jumlah nilai rata-rata 4,56 (sangat baik), penilaian kemampuan merias menurut  wajah panggung penari remo memperoleh nilai 3,6 (sangat baik), respon peserta pelatihan mendapat jumlah nilai rata-rata 92,5% (sangat baik).

Kata Kunci: Pelatihan, Tata Rias Panggung Penari Remo
Pengaruh Kadar Sari Buah Stroberi (Fragaria vesca L.) Terhadap Kualitas Masker Gel Peel Off
Authors: Juliana putri  , Ambarwati Neneng Siti Silfi
Published: January 2023

Masker termasuk kosmetik depth cleansing yaitu kosmetik yang bekerja secara mendalam karena dapat mengangkat sel-sel kulit mati. Ciri-ciri masker wajah yaitu dapat dioleskan pada kulit wajah, menimbulkan rasa kencang pada kulit dan terdapat unsur zat yang bermanfaat untuk kulit.

 

         Penelitian ini bertujuan untuk mengetahui adakah pengaruh kadar sari buah stroberi terhadap kualitas masker gel peel off. Penelitian ini menggunakan metode penelitian eksperimen. Variabel bebas dalam penelitian ini adalah sari buah Stroberi dengan konsentrasi 10%, 15%, 20%, sedangkan variabel terikatnya adalah kualitas kadar sediaan masker gel peel off sari buah Stroberi. Teknik pengumpulan data yang digunakan adalah metode observasi melalui uji pH, uji organoleptik, uji hedonik yang dilakukan oleh 3 dosen ahli farmasi. Analisis data dengan menggunakan uji normalitas dengan program SPSS dan dilanjutkan uji Friedman Test. Berdasarkan hasil penelitian dan pembahasan menunjukkan bahwa sari buah Stroberi dapat diformulasikan dalam sediaan masker gel peel off dengan variasi konsentrasi 10%, 15%, dan 20%. Hasil dari uji organoleptik dan uji hedonik menunjukkan bahwa konsentrasi masker gel peel off terbaik ialah formula 3 dengan sari buah stroberi 20%. Hasil uji pH menunjukkan semua gel yang dihasilkan memenuhi kriteria pH kulit yaitu dalam interval 4,5-7. Hal ini sesuai dengan yang diharapkan, yaitu pH berada pada rentang pH normal kulit yaitu antara 4.5 -7.
PERSEPSI ALUMNI PROGRAM STUDI PENDIDIKAN TATA RIAS TERHADAP KESESUAIAN KURIKULUM MATA KULIAH KECANTIKAN KULIT DAN RAMBUT DENGAN BIDANG KERJANYA
Authors: Puti Rania Larasati
Published: January 2023

Kurikulum Mata Kuliah Kecantikan Kulit dan Rambut sejak tahun 2019 belum mengalami evaluasi. Mengingat perkembangan sains dan teknologi yang kian pesat dan beragam pekerjaan alumni, maka diperlukan evaluasi kurikulum untuk melihat sejauh mana kurikulum tersebut dapat diaplikasikan dalam pekerjaan alumni. Penelitian ini bertujuan untuk mengetahui apakah adanya kesesuaian kurikulum mata kuliah kecantikan kulit dan rambut dengan bidang kerja alumni saat ini sebagai hairstylist, hairdresser, dan wirausaha salon. Penelitian ini menggunakan pendekatan kuantitatif deskriptif dengan metode survey serta sampel berjumlah 30 orang. Hasil penelitian ini menunjukkan bahwa sebanyak (66,7 %) responden menilai tujuan kuliah sangat sesuai dengan pekerjaannya. Sebanyak (70,0 %) responden menilai materi perkuliahan sangat sesuai dengan bidang kerjanya. Sebanyak (56,7 %) responden menilai media perkuliahan yang digunakan sangat sesuai. Sebanyak (70,0 %) responden memberikan penilaian metode yang digunakan sangat sesuai dengan bidang kerjanya. Sebanyak (60,0 %) responden memberikan penilaian sangat sesuai untuk aspek sarana dan prasarana. Kemudian, sebanyak (70,0 %) responden menilai sangat sesuai untuk aspek evaluasi. Secara keseluruhan, dapat disimpulkan bahwa sejumlah 19 responden (63,3 %)  menilai kurikulum mata kuliah kecantikan kulit dan rambut yang digunakan sangat sesuai dengan pekerjaan alumni saat ini sebagai hairstylist, hairdresser, dan wirausaha salon.
PERSEPSI WANITA TERHADAP MANFAAT KOSMETIK PERAWATAN RAMBUT DARI BAHAN DASAR BUAH ATAU SAYUR UNTUK MENGATASI PERMASALAHAN PADA RAMBUT
Authors: YULIA ELVYRA
Published: January 2023

Penelitian ini bertujuan untuk mengetahui persepsi wanita terhadap manfaat kosmetik perawatan rambut dari bahan dasar buah dan sayur untuk mengatasi permasalahan pada rambut. Populasi penelitian ini adalah semua wanita usia produktif 17-45 tahun yang pernah melakukan perawatan rambut di rumah maupun di salon kecantikan. Penelitian ini menggunakan sampel sebanyak 30 orang responden.

            Metode penelitian ini ialah metode survey dengan mengambil data bersifat kuantitatif. Pengambilan data mengenai persepsi ibu-ibu rumah tangga terhadap manfaat kosmetik buah dan sayur dalam perawatan rambut. Metode pengumpulan data kuantitatif diperoleh dengan penyebaran kuisoner menggunakan pernyataan tertutup sebagai instrument utama untuk pengumpulan data, guna medapat gambaran tentang aspek pengetahuan, pandangan dan respon wanita terhadap manfaat kometik buah dan sayur dalam perawatan rambut.

             Instrumen penelitian yang digunakan untuk mengetahui persepsi wanita tersebut menggunakan dengan skala likert dengan rentang 1 - 4 tingkat.  Jawaban dari gradasi sangat positif (skala 4) sampai sangat negative (skala 1).  Uji validitas instrument ditentukan dengan menggunakan r tabel kemudian diuji reliabilitasnya.        

             Hasil penelitian ini diharapkan akan dapat menjawab apakah selanjutnya perlu dilakukan sosialisasi atau penyuluhan tentang pentingnya pengetahuan wanita terhadap kosmetik berbahan dasar buah dan sayur untukperawatan rambut sehari-hari.
Fakto-faktor Keputusan Konsumen Dalam Membeli Kosmetika Perawatan Wajah
Authors: Nindya Dwiana Putri
Published: January 2023

Industri di bidang kecantikan, khususnya kosmetika sedang berkembang dengan pesat. Dimana hal ini diimbangi dengan semakin banyaknya pertimbangan dalam memilih suatu produk yang dilakukan oleh konsumen dalam memutuskan pembelian kosmetika. Tujuan penelitian ini adalah mengetahui dan menganalisis faktor-faktor apa saja yang mempengaruhi konsumen dalam memutuskan pembelian kosmetika perawatan wajah. Pada zaman ini, perawatan wajah sudah menjadi kegiatan rutin yang dilakukan wanita maupun pria dari berbagai kalangan. Selain dilakukan di salon kecantikan, perawatan wajah juga banyak dilakukan secara pribadi karena mudahnya mendapatkan kosmetika perawatan wajah yang dijual secara umum dan beragamnya kosmetika perawatan wajah yang tersedia. Metode penelitian yang digunakan adalah penelitian kualitatif dengan kajian pustaka. Hasil dari penelitian ini adalah terdapat empat faktor yang secara signifikan mempengaruhi keputusan konsumen membeli kosmetika perawatan wajah, yaitu faktor budaya, sosial, pribadi dan psikologis.
VIDEO TUTORIAL PENERAPAN TEKNIK BAKAR FOUNDATION UNTUK KULIT WAJAH BERMINYAK
Authors: Rizka Fauziah Dwi Utami  , Eti Herawati
Published: January 2023

Abstract

Rizka Fauziah Dwi Utami, 1510519041, Video Tutorial Applying Foundation Burning Technique For Oily Facial Skin, Final Project: Diploma 3 Study Program of Cosmetology, Faculty of Engineering, State University of Jakarta, 2022.

 

The process of cooking or heating the foundation will separate the formula that is in the foundation. All the active ingredients contained in the foundation will evaporate or melt. That way, the foundation will tend to dry when applied to the face. As long as the effect is dry, its use is more suitable for your facial skin. The skin is caused by high sebum production. Sebum is a natural oil that functions to protect and keep the skin clean, but if you burn it for a long time, it will damage the properties of the foundation itself. The process of making this video tutorial consists of pre-production, production, and post-production processes. The feasibility test was carried out by 2 experts, namely: material experts and media experts. The results of the overall assessment and video tutorials on applying the foundation burn technique for facial skin have a 90% rating for material experts and 93% for media experts who fall into the very good category in overall results. Based on these results, the key is that video tutorials are very suitable to be used as references and learning resources for students of Jakarta State University Makeup and the general public.

 

Keywords: Video Tutorial, Application of Foundation Burn Technique, Oily Facial Skin.
Analisis strategi bisnis menggunakan digital marketing pada UMKM pasca pandemi covid-19
Authors: Rizky Muhammad Farhan , Permana Erwin
Published: January 2023

Studies on business strategy analysis using digital marketing are quite a lot done for large company loci. But the study of business strategy analysis using digital marketing for MSMEs is still growing. This study aims to analyze business strategies using digital marketing for MSMEs after the COVID-19 pandemic. The research was conducted with a descriptive qualitative approach. The data was obtained through searching and observing various digital applications related to MSME marketing. The results showed that in the post-covid-19 pandemic, there was a habit of people who like to shop online and a business strategy was needed to deal with this and to maintain the existence of MSMEs. with digital marketing. Business strategies can be implemented in post-pandemic MSMEs as a digitalization strategy using digital marketing, by applying search engine marketing, digital content marketing, Pay-per-click Ads, to influencer marketing. Although the pandemic has begun to end, it is believed that the use of digital media will not decrease
Mata pelajaran produktif, prakerin dan motivasi belajar : kesiapan kerja siswa
Authors: Naim Naim
Published: January 2023

The purpose of this study was to determine the effect between the independent variable and the dependent variable either partially or simultaneously. The population according to Arikonto (2010:173) is the entire research subject. Population research is done if the researcher wants to see all the elements in the population. The population in this study were all students of class XI SMK Islam Donomulyo Malang Regency in the 2021/2022 academic year which consisted of 2 classes totaling 65 students. Data was collected by using questionnaires and documentation methods. Validity test with Product moment technique and Alpha Crombach reliability test, test data analysis requirements using classical assumption test and multiple linear regression analysis. Hypothesis testing using t test and F test. The results of this study show that there is a significant effect of the variable mastery of productive subjects, industrial work practices (prakerin) and learning motivation on the work readiness of class XI students at SMK Islam Donomulyo Malang Regency in the 2021/2022 academic year. of 49.905%. There is a significant influence on the mastery of productive subjects on the work readiness of class XI students at the Donomulyo Islamic Vocational School, Malang Regency, for the 2021/2022 academic year by 51.31%. There is an influence of prakerin on the work readiness of class XI students at Islamic Vocational School Donomulyo, Malang Regency in the academic year 2021/2022 by 31.84%, There is a significant influence of learning motivation on the work readiness of class XI students at SMK Islam Donomulyo, Malang Regency in the Academic Year 2021/2022 by 33.05%.
Prevalencia de lesiones pulpares y periapicales en pacientes que acuden al servicio de odontología del CAP III El Agustino Red Asistencia Almenara Essalud de diciembre 2009 a julio del 2011
Authors:   , Quesada Andrade Monica Paola
Published: January 2023

Este trabajo se realizó para evaluar la continuidad de lesiones de la pulpa y del área periapical, ya que son patologías que van de la mano y en algunos casos son el motivo principal de la consulta. Su conocimiento permitirá realizar un mejor diagnóstico y tratamiento evitando cualquier complicación. Con la finalidad de determinar la relación entre las lesiones de la pulpa y del área periapical según diversos factores se hizo un estudio observacional- transversal en 825 pacientes, 338 varones (41%) y 486 mujeres (58,9%), que fueron al servicio del centro odontológico del CAP III-EL Agustino durante el tiempo de diciembre del 2009 y julio del 2011, por medio de las historias clínicas de la institución. Se realizó la comparación según género, edad, procedencia, signos, síntomas, estado civil, nivel educativo, complicaciones, etiología y pieza dentaria. Para hacer el estudio de comparación de los grupos de las lesiones y cada sub grupo, se utilizó para cada variable la prueba de Chi-cuadrado (ρ < 0,05); encontrando diferencia altamente significativa entre las lesiones de la pulpa y del área periapical, y diversos factores. Se concluye que las lesiones de la pulpa y del área periapical tiene una alta prevalencia con un 34,7% y es de tipo multifactorial.
Comparación de la precisión de dos localizadores apicales en la determinación de la longitud de trabajo de piezas dentarias con perforaciones simuladas a diferentes niveles del conducto radicular
Authors:   , Astocaza Reátegui Teresa Flora
Published: January 2023

Introducción: El objetivo de la investigación ha sido confrontar la exactitud de dos localizadores en su longitud de trabajo de dientes que presenten perforaciones en diversos niveles de la raíz. Materiales y métodos: Se utilizó treinta y seis premolares inferiores unirradiculares, se dividieron en tres de doce dientes cada grupo, el primero consta de dientes con perforación medio y apical, el segundo consta de dientes con perforación cervical-medio y el tercero consta de dientes con perforación apical. Se utilizó los localizadores de cuarta generación y para la medida del diente se usó un calibrador, realizando estadística inferencial y descriptiva. Resultados: En cuanto se hizo la comparación de la precisión de la longitud por ambos localizadores en dientes con perforación simulada en relación a la longitud real se observaron diferencias significativas. Conclusión: El localizador Propex Pixi tuvo mejor precisión para determinar la longitud real en dientes que tengan perforaciones de la raíz.
Frecuencia de cumplimiento de la Guia Canadiense en trauma encefálico leve en el Hospital de Emergencias José Casimiro Ulloa 2021
Authors:   , Loja Blancas Rosario
Published: January 2023

El uso de tomografía cerebral para el trauma craneoencefálico ha sido bien establecido y es de uso rutinario en medicina de emergencia. El estudio de tomografía es un estudio de diagnóstico por imágenes, ha evolucionado en su rapidez, sensibilidad y especificidad en el área del sistema nervioso central. En trauma encefálico, con resultado de tomografía normal, el valor predictivo negativo alcanza el 100% y ha eliminado la necesidad de admisión a hospitales u observación después de la lesión cerebral en un paciente neurológicamente intacto. La tomografía cerebral es por tanto; una prueba confiable y simple para excluir lesiones, que agiliza el cuidado del paciente en el departamento de emergencia para un alta segura. Durante las últimas décadas se ha discutido acerca de las indicaciones de la tomografía cerebral para trauma craneoencefálico. La guía de Canadá para tomografía cerebral estudia el trauma cerebral leve con criterios de inclusión de testigos de desorientación o pérdida de conciencia. El uso clínico de esta regla ha llevado a alguna reducción en las imágenes de tomografía cerebral por trauma cerebral leve; pero en centros donde no se aplica, las solicitudes siguen en incremento. De lo expuesto planteamos la siguiente pregunta: ¿Cuál es el grado de cumplimiento de uso de tomografía cerebral luego de aplicar la guía canadiense en pacientes con traumatismo encefalocraneano leve en el Hospital Casimiro Ulloa, durante el periodo 2021?
Seguridad y salud ocupacional y su relación con el desempeño laboral de los colaboradores de la empresa Thyssenkrupp Elevadores S.A.C., 2020
Authors:   , Marcelo Seminario Ernesto Guillermo , Salazar Ventura Estefany Julissa
Published: January 2023

Establecer cómo la seguridad y salud ocupacional está relacionada con el desempeño laboral de los colaboradores de la organización Thyssenkrupp Elevadores S.A.C. representó la principal finalidad de este estudio. Presenta un enfoque cuantitativo, de diseño no experimental y del tipo transversal, y es aplicada con nivel correlacional, la población se compuso por 132 colaboradores. Asimismo, mediante el muestreo no probabilístico por juicio u opinión no intencional se determinó una muestra conformada por 114 colaboradores. Fue usada la encuesta como técnica, en la primera variable fue empleado el cuestionario como instrumento y en la segunda variable se usó una cartilla de valoración. Los resultados alcanzados demostraron que la seguridad y salud ocupacional sobre el desempeño laboral de los colaboradores se correlaciona significativamente, una correlación muy alta de 0.856 conforme al estadístico de Spearman con nivel de significancia de 0.000 entre ambas variables así lo evidenció.
Determinación del riesgo potencial por ingesta de alimentos contaminados con metales pesados en las ciudades de Moyobamba, Lamas, Tarapoto Juanjuí y Tocache
Authors:   , Rivero Paucar Maria Claudia
Published: January 2023

La contaminación de alimentos por metales pesados es una problemática de vital importancia para la seguridad alimentaria y la salud de las personas. Por ello, es fundamental conocer el riesgo a la exposición a través de la ingesta. La presente investigación tuvo como objetivo evaluar el riesgo potencial por ingesta de Cd, Pb y Ni en el arroz (Oryza sativa), lechuga (Lactuca sativa), aguaje (Mauritia flexuosa) y ají charapita (Capsicum frutescens), adquiridos en los principales mercados de las ciudades de Moyobamba, Lamas, Tarapoto, Juanjuí y Tocache. Para este propósito se desarrollaron encuestas de consumo en las principales ciudades de la región San Martín (Tocache, Juanjuí, Tarapoto, Lamas y Moyobamba) y se colectaron muestras de arroz, lechuga, ají charapita y aguaje en los principales mercados de estas ciudades. Las muestras pasaron por un proceso de lavado, secado y molienda para determinar las concentraciones de Cd, Pb y Ni mediante la técnica de ICP-MS. Con esta información se realizaron cálculos de análisis de riesgo, dosis diaria promedio (ADD), cociente de riesgo (HQ) y el índice de peligro (HI). Los resultados expresan que la mayoría de las concentraciones de Cd, Pb y Ni en los alimentos evaluados sobrepasan los estándares permitidos estipulados por la WHO, (2007), Unión Europea, (2006) y el Codex Stan 193-1995, (2009). Se destacó que pese a tener altos niveles de metales pesados en arroz (Oryza sativa), lechuga (Lactuca sativa), aguaje (Mauritia flexuosa) y ají charapita (Capsicum frutescens) podrían no inducir a un riesgo potencial a la salud en la región San Martín. Sin embargo, al diferenciar el índice de peligro entre adultos y niños, se vio que este último es el más expuesto por el consumo total de estos alimentos, especialmente la ciudad de Juanjuí.
Estimación de la población de gatos con dueño y sus características generales en el distrito de Chorrillos, Lima-Perú, 2018
Authors:   , Inga Yañez Arturo
Published: January 2023

El objetivo del presente estudio fue estimar la población de gatos con dueño y describir sus características generales en el distrito de Chorrillos, Lima – Perú, 2018. La metodología consistió en aplicar una encuesta en viviendas que fueron seleccionadas mediante un muestreo aleatorio de distribución proporcional. Se obtuvieron 756 encuestas válidas que fueron principalmente de casas (82,8%±2.7), departamentos (4,8%±1.5) y viviendas precarias (12,4%±2.4). La población de gatos con dueño estimada fue de 42 174, la relación persona: gato fue de 8.08 y el promedio de gatos por vivienda fue de 0.62 (469/756). Hubo un amplio predominio de la raza mestiza (97.7%±1.4) sobre la raza pura (2.3%±1.4). La tenencia de hembras fue ligeramente mayor (51.6%±4.52) a la de machos (45.8%±4.51). El 53.9%±4.5 de los gatos habían sido desparasitado en los últimos 6 meses, el 28.8%±4.1 habían sido vacunados contra la rabia en el último año y el 25.6%±3.9 de los gatos habían sido esterilizados. El 95.1% de gatos no sobrepasa los 7 años, estando su mayoría (44.8%±4.5) en el grupo etario Joven, es decir mayores de 7 meses, pero sin superar los 3 años. La información de este trabajo debe ser tomado en cuenta con el fin de mejorar la planificación y ejecución de programas sanitarios en el distrito.
Androgen supplement did not accelerate tunica albuginea remodeling to facilitate penile growth
Authors: Li Tao , Tian Yuan , Tian Ye , Chen Peng , Zhang Junhao , Du Guangshi , Li Lei , Jiang Yiting , Jiang Kehua
Published: January 2023

Penile size is closely concerned and short penis contributes serious sexual dysfunction and tremendous psychological problems to couples. Androgen is essential for penile development and testosterone replacement is recommended to patients with micropenis. We previously proved that inhibiting activity of lysyl oxidase (Anti-lysyl oxidase, Anti-LOX) combined with vacuum erectile device (VED) lengthened penis by remodeling tunica albuginea. We thus explored whether androgen supplement could accelerate tunica albuginea remodeling (induced by Anti-LOX + VED) to promote penile growth. Forty-two SD male rats (4 weeks old) were purchased and divided into 7 groups: control, Anti-LOX, HCG, VED (with a negative aspirated pressure of -300 mmHg), Anti-LOX + VED, HCG + VED, and Anti-LOX + HCG + VED. After an intervention for 4 weeks, all rats’ penile length, exposed penile length, and erectile function were measured. Serum samples were collected to detect hormone levels and penile corpus cavernosum were harvested for histo-pathological analysis. All intervention groups showed significantly longer penis than controlled rats. Anti-LOX sharply increased penile length and exposed length by 15% and 9% respectively, this lengthening effect was more obvious in Anti-LOX + VED group (26% and 19%, respectively). Although HCG promoted penile length by 8%, this effect was slight for exposed length (3%). Moreover, Anti-LOX + HCG + VED dramatically increased penile length and exposed length by 22% and 18%, respectively, which was similar with that in Anti-LOX + VED (26% and 19%, respectively). HCG dramatically stimulated testosterone and dihydrotestosterone secretions than control group, whether with or without Anti-LOX and VED; while it induced more AR expression than other groups. Finally, all procedures did not improve or deteriorate normal erectile function. Although we verified that Anti-LOX + VED lengthened penis by inducing tunica albuginea remodeling, however, androgen supplement did not synergize with Anti-LOX + VED to accelerate albuginea remodeling to facilitate penile growth.
Prophylactic Antibiotic Administration in Adults with Out-of-Hospital Cardiac Arrest: A Systematic Review and Meta-analysis
Authors: Wang Ying , Lin Jian-dong , Xiao Wen-biao , Xiao Xiong-jian
Published: January 2023

Background: There is a debt whether prophylactic antibiotic use may further hamper prognosis of patients with OHCA. In this study, we have performed a meta-analysis to assessed the effect of prophylactic antibiotic administration.
Methods: Electronic databases were searched for trials in which prophylactic antibiotic had been administered to adults with OHCA. The predefined primary outcome was the incidence of pneumonia.
Results: The included 6 trials enrolled a total of 5061 patients. Prophylactic antibiotic administration was not associated with decreased incidence of pneumonia and early-onset pneumonia (OR 0.44; 95%CI (0.19, 1.02); p= 0.056; I2=95.9% vs. OR 0.54; 95%CI (0.22, 1.32); p= 0.175; I2=46.8%). No adverse effect on mortality was found among trials (OR 1.17; 95%CI (0.46, 2.97); p= 0.748; I2=87.8%).
Conclusion: Given this conflicting collection of limited quality, no difference in the incidence of pneumonia (including early-onset pneumonia) and mortality was found when receiving prophylactic antibiotic administration in patients suffering out-of-hospital cardiac arrest. Randomized trials are warranted to define the best prophylactic antibiotic protocol.
PROSPERO registration number: CRD42022341601. 07 March, 2022 retrospectively registered.
Effect of demographic factors on the outcome of early intervention therapy among the children with autism spectrum disorder in Bangladesh
Authors: Hafiz Promugdha , Hoque Mahfara , Rahman Md. Sahidur
Published: January 2023

Autism Spectrum Disorders is a group of neuro-developmental disorders affecting one in every 100 children worldwide. The cornerstone of ASD management is based on early intervention programs targeted to improve communication, socialization, and behavior skills. This study, conducted at the child development center of a tertiary care hospital in Chattogram city of Bangladesh, aimed to determine the effect of age and other demographic variables on the outcome of early intervention therapy on the improvement of skills of children with ASD. Participants included two groups of children (75 per group) with ASD having different ages - below three years and three to five years. The diagnosis was confirmed using different tools like neurodevelopment assessment form, Bayley scales, M Chat, ICD 10 criteria, and how and why. The intervention was provided on a 1:1 basis and given six subsequent sessions every two months throughout the one-year study period. Statistically significant improvements were observed in different skills in the young age children than in the older group. Almost half of the children (49.3%) from the old age group remained in own agenda stage. On the other hand, all children of young age have significantly improved in early communicator (46.7%), the requester (41.3%), and partner (12%) stages. Moreover, the monthly family income of children posed a significant effect on the outcome of the intervention therapy. The study suggests the initiation of early intervention therapy before age three to get a significant improvement in communication skills of children.
Downregulation of KLF14 accelerated cellular senescence and aging
Authors: Hou Yuli , Song Qiao , Wang Yaqi , Liu Jing , Cui Yuting , Zhang Xiaomin , Zhang Jingjing , Fu Jingxuan , Cao Min , Zhang Chi , Liu Congcong , Wang Xiaoling , Duan Huanli , Wang Peichang
Published: January 2023

Aging has been considered as a risk factor in many diseases, thus, comprehensively understanding the cellular and molecular mechanisms of delayed aging is important. Here we investigated whether KLF14 is a suppressor of cellular senescence and aging. In our research, KLF14 levels significantly decreased not only in the serum and lymphocytes of healthy people but also in the cells and tissues of mice with aging. We performed in vitro and in vivo experiments on cells and mice to reveal the function of KLF14 in aging. KLF14 deficiency facilitates cellular senescence and aging-related pathologies in C57BL/6 mice, whereas KLF14 overexpression attenuates cellular senescence. Mechanistically, KLF14 delays aging by binding to the POLD1 promoter to positively regulate POLD1 expression. Remarkably, cellular senescence mediated by KLF14 downregulation could be alleviated by POLD1expression. In addition, perhexiline, an agonist of KLF14, could delay cellular senescence and aging-related pathologies in SAMP8 mice by inducing POLD1 expression, as perhexiline could enhance the effect of KLF14’s transcription activation to POLD1 by elevating the binding level of KLF14 to the POLD1 promoter. Our data indicate that KLF14 might be a critical element in aging by upregulating POLD1 expression, indicating that the activation of KLF14 may delay aging and aging-associated diseases.
Redefining the connectome: A multi-modal, asymmetric, weighted, and signed description of anatomical connectivity
Authors: Tanner Jacob , Faskowitz Joshua , Teixeira Andreia Sofia , Seguin Caio , Coletta Ludovico , Gozzi Alessandro , Misic Bratislav , Betzel Richard
Published: January 2023

The macroscale connectome is the network of physical, white-matter tracts between brain areas. The connections are generally weighted and their values interpreted as measures of communication efficacy. In most applications, weights are either assigned based on imaging features--e.g. diffusion parameters--or inferred using statistical models. In reality, the ground-truth weights are unknown, motivating the exploration of alternative edge weighting schemes. Here, we explore a multi-modal (combining diffusion and functional MRI data) regression-based, explanatory model that endows reconstructed fiber tracts with directed and signed weights. Benchmarking this method on Human Connectome Project data, we find that the model fits observed data well, outperforming a suite of null models. The estimated weights are subject-specific and highly reliable, even when fit using relatively few training samples. Next, we analyze the resulting network using graph-theoretic tools from network neuroscience, revealing bilaterally symmetric communities that span cerebral hemispheres. These communities exhibit a clear mapping onto known functional systems. We also study the shortest paths structure of this network, discovering that almost every edge participates in at least one shortest path. We also find evidence of robust asymmetries in edge weights, that the network reconfigures in response to naturalistic stimuli, and that estimated edge weights differ with age. In summary, we offer a simple framework for weighting connectome data, demonstrating both its ease of implementation while benchmarking its utility for typical connectome analyses, including graph theoretic modeling and brain-behavior associations.
DeepTrace: Learning to Optimize Contact Tracing in Epidemic Networks with Graph Neural Networks
Authors: Tan Chee Wei , Yu Pei-Duo , CHEN Siya , Poor H. Vincent
Published: January 2023

The goal of digital contact tracing is to diminish the spread of an epidemic or pandemic by detecting and mitigating public health emergencies using digital technologies. Since the start of the COVID-$19$ pandemic, a wide variety of mobile digital apps have been deployed to identify people exposed to the SARS-CoV-2 coronavirus and to stop onward transmission. Tracing sources of spreading (i.e., backward contact tracing), has been used in Japan and Australia, has proven crucial as going backward can pick up infections that might otherwise be missed at superspreading events. Can network science robustify backward contact tracing? How to automatically optimize data-driven contact tracing? This will entail a learning by design approach. In this paper, we formulate the forward and backward contact tracing problem for contagion source inference as a maximum-likelihood (ML) estimation problem with iterative infection networked data sampling. This covers a well-known special case of a priori knowing the entire infection network topology. As the full infection network topology is rarely accurately known upfront, this problem is challenging to solve due to its combinatorial complexity, problem scale and the speed of spreading as a disease virus becomes more infectious over time (e.g., the COVID-19 Omicron variant). We propose a Graph Neural Network (GNN) learning framework, DeepTrace, to efficiently compute the ML estimator and to track the most-likely superspreader iteratively as the contact tracing networked data grows in size. The GNN supervised learning leverages the likelihood-estimation structure so as to endow the training set with useful topological features to facilitate accelerated training time and convergence behavior. Using data of COVID-19 variants with different infectiousness property, we show that DeepTrace has better performance than the state-of-the-art for identifying superspreaders and can serve as a statistically rigorous basis to design scalable digital contact tracing for future epidemics.
Klotho Reduces the Risk of Osteoporosis in Postmenopausal Women: A cross-sectional Study of the National Health and Nutrition Examination Survey (NHANES)
Authors: Jiang Jialin , Liu Qinyu , Mao Yaqian , Wang Nengyin , Lin Wei , Li Liantao , Liang Jixing , Chen Gang , Huang Huibin , Wen Junping
Published: January 2023

Background: We explored a convenient and accurate factor to predict the risk factors of osteoporosis (OP) in postmenopausal women based on the study of the database.
Methods: This is a retrospective study. We searched and collected the data of 3 survey cycles in the National Health and Nutrition Examination Survey (NHANES) database, and included 885 postmenopausal women over 50 years old. All participants took dual-energy X-ray absorptiometry examination and serum Klotho test at the time of investigation. We used logistic regression to predict the risk model, and used P for trend and restricted cubic spline (RCS) to explore the nonlinear relationship between variables.
Results: The influencing factors of OP included age, race, BMI and Klotho. Klotho is a protective factor (OR[log2Klotho] =0.561, P =0.023). We build a prediction model to evaluate the prediction ability. The C-index is 0.765, indicating a good prediction ability. After adjusting the full variable, P for trend has significant difference. RCS showed that when Klotho concentration reached 824.09pg/ml, the risk of OP decreased significantly.
Conclusion: Through the study of NHANES database, we propose that Klotho is a protective factor for postmenopausal OP, and it can be used to assess the risk of OP.
Is the proximal femoral nail antirotation better than hemiarthroplasty ? : A Meta-analysis involving 1283 elderly patients with unstable intertrochanteric fractures
Authors: OUYang jian-feng , Yuan hong , Li Binquan , Du Xiufan
Published: January 2023

BACKGROUND

Surgical treatment is an accepted method for intertrochanteric fractures. For the older adults accompanied by severe osteoporosis and other diseases, how to treat intertrochanteric fractures still remains controversial.

OBJECTIVE

To evaluate the effectiveness and safety of proximal femoral nail antirotation versus hemiarthroplasty in the treatment of unstable intertrochanteric fractures in older adults through meta-analysis.

METHODS

According to the Cochrane system evaluation, a computer-based retrieval of Medline、Pubmed、SPINGER、John Wiley、Science Direct、Elsevier、SAGE、EBSCO databases between 2000 and 2018 was performed. The keywords were “proximal femoral nail ant-irotation or PFNA, hemiarthroplasty, unstable intertrochanteric fractures” in English respectively. The literate was screened based on inclusion and exclusion criteria, and then quality evaluation was conducted. Meta-analysis was undergone on the Rev-Man 5.1.

RUSULTS :

(1) Twelve clinical trials were included, involving 1283 patients, and including 6 randomized controlled trials. (2) Meta-analysis results showed that the operation time in the proximal femoral nail antirotation group was shorter [MD=-17.02, 95%Cl(-29.64,-4.77), P < 0༎01], intraoperative blood loss was lower [MD=-216.91, 95༅CI(-269.84, -163.99), P < 0.01], hospitalization time was shorter [MD=-1.72, 95༅CI(-3.25, -0.19), P < 0.05], the postoperative in HSS was higher [MD = 4༎78, 95༅Cl(2.59, 6༎97), P < 0.01], excellent and good rate of postoperative HSS was better [RR = 1.54, 95༅Cl(1.09, 2.16, P < 0.05], compared with the hemiarthroplasty group. (3) In the hemiarthroplasty group, the ambulation time was earlier [MD = 4.8, 95༅CI(1.31, 8.29), P < 0.01], but the rate of mortality was higher [RR = 0.5, 95༅Cl༈0.36, 0.70, P < 0.01], compared with the proximal femoral nail antirotation group. (4) There was no significant difference between two groups in the postoperative Implant-related or medical complications, re-operation rates and infection rate (P > 0.05).

CONCLUSION

For the treatment of senile unstable intertrochanteric fractures, the proximal femoral anti-rotation intramedullary nailing is faster, less intraoperative bleeding, shorter hospital stay, better postoperative function and lower mortality, and its efficacy is better than that of hemiarthroplasty.
Integration of Fractal Geometry and Correspondence Analysis Geochemistry Methods to Reconnaissance High-Potential Promising Areas in a Field of NE Iran
Authors: Hosseini Seyed Aliakbar , Khah Nasser Keshavarz Faraj , Kianoush Pooria , Shirinabadi Reza
Published: January 2023

The background Anomaly separation is one of the essential stages in geochemical explorations. Most geochemical and geostatistical works in mining exploration aim to identify an anomaly better based on scientific discussions. In this paper, Integrating the correspondence analysis and fractal method, the results of analysis data for river sediment sampling at the Khusf area in NE Iran have been investigated. Correspondence analysis with 170 data samples and 20 elements was done. According to correspondence analysis, separating one or several elements is the reason for anomalous value in the study area. Separating one or several samples is the reason for the aimed elements at the studied samples. The results of seven samples show the highest concentration relative to the variables Pb, As, and Cd elements. The correspondence analysis results show that the Khusf area at some locations for Pb, Cd, and as elements have been probability anomalous. After the correspondence analysis, the best variogram for the Khusf area using Win_Gslib software was obtained. The obtained variogram and designed network for estimation by the kriging method at the mentioned area was used. Therefore using the fractal method, three statistical sets determined that the third set showed the anomaly for Pb, Cd and As elements nearly. The separation value, respectively, determined about 55, 7.2, and 0.88 ppm. Finally, it is suggested that this region has the potential of essential metals, especially of the above elements, and will carry out geophysical operations on a local identification scale.
Consequences of polyploidy and divergence as revealed by cytogenetic mapping of repetitive elements in African clawed frogs (Xenopus, Pipidae)
Authors: Fornaini Nicola R. , Bergelová Barbora , Gvoždík Václav , Černohorská Halina , Krylov Vladimír , Kubíčková Svatava , Fokam Eric B. , Badjedjea Gabriel , Evans Ben J. , Knytl Martin
Published: January 2023

Repetitive elements have multiple copies in a genome and have been identified in several amphibian genomes using whole genome sequencing, but few studies have used cytogenetic mapping to visualize these elements in this vertebrate group. Here we compared the numbers and positions of repetitive elements in diploid and tetraploid species of the genus Xenopus, specifically between the diploid Xenopus tropicalis and its close allotetraploid relative X. calcaratus (both from Silurana subgenus), and also in more phylogenetically distant allotetraploids from the amieti, muelleri, and laevis species groups (all from subgenus Xenopus). Results allowed us to qualitatively evaluate the relative roles of polyploidization and divergence in the evolution of repetitive elements because our focal species include allotetraploid species derived from two independent polyploidization events – one closely related to the diploid species and one that is more distant. We used fluorescence in situ hybridization (FISH) to map the U1 and U2 small nuclear RNA (snRNA), histone H3, and retroelement Rex3 repeat loci. Our results demonstrated that U1 and U2 snRNA loci were conserved in copy number and position in the Silurana genomes, with one copy of U1 and U2 snRNA in diploid genome and one copy in each subgenome of allotetraploid species in subgenus Silurana and the muelleri species group. However, snRNA content varied among allotetraploid species in the amieti and laevis species groups, with only one U1 and U2 snRNA copy present in the entire allotetraploid genome of three species. Probes interrogating repetitive H3 and Rex3 loci were present on all chromosomes in diploid and allotetraploid species in subgenus Silurana, and in the muelleri species group. In the amieti and laevis species groups, H3 and Rex3 repeats were present on about half of all chromosomes. Overall, the results indicated that variation in the position and copy number of repetitive elements increases with phylogenetic distance, with high conservation in diploid and tetraploid Silurana species but more variation between Xenopus subgenera and among species groups in the subgenus Xenopus. In general and as expected, the effect of allotetraploidization was to increase the copy number of repetitive elements relative to diploid species, with the exception of the amieti and laevis species groups.