bluuebunny/crossref_metadata_2025 huggingface dataset:
An Overview of the Middle Paleolithic of Northern Burgundy/Franche-Comté
Authors: Lamotte Agnès , Hallégouet Bernard , Huguenin Gilles , Aubry Denis , Debenham Nick
Published: April 2024

Since prehistoric times, the northern part of Bourgogne/Franche-Comté (east central France) has been an attractive transition area for populations and fauna, allowing movement from central to western Europe (and vice versa) via the Upper Danube Basin and the Belfort Gap. It also constitutes a North-South and South-North transition area via the main river valleys (Saône, Rhône, Rhine, Meuse, Moselle). In this region, the topography is varied and defined by hills that rise to between 300 and 600 m asl, including the Morvan and Côte-d’Or mountains, the Vosges hills and mountains and the foothill plateaux of the Jura. Prehistoric populations settled here at different times and for different durations. The late Middle Paleolithic and the Upper Paleolithic are the best represented prehistoric periods in the region. Since 2005, our research on the Middle Paleolithic has revealed that the lithic assemblages have many affinities with those of central Europe (Alth-mülian, Micoquien, Eastern Mousterian) including with facies dating to the transition with the Upper Paleolithic (Szélétien, Jankovichien, etc.). A spatio-temporal study shows that while topographical, geological (including raw material availability) and environmental factors facilitated the movement of and/or occupation by people and animals, this scenario cannot be applied in a blanket manner, varying locally and over time. Recent integrated scientific research, encompassing absolute dating, paleoenvironmental work, zooarchaeological studies and in-depth techno-typological analyses, sheds new light on the occupation of this part of France and Europe.
Middle Paleolithic Sites atop the Scoria Cones of the East Eifel Volcanic Field of the Central Rhine Valley
Authors: Bosinski Gerhard , Conard Nicholas J.
Published: April 2024

While controversial from the point of view of its impact on the landscape, the large-scale mining of lava from the scoria cones of the East Eifel led to the discovery of many Middle Paleolithic find horizons within the volcanic craters atop these elevated positions. This paper summarizes the important finds from sites including Plaidter Hummerich, Schweinskopf, Tönchesberg and Wannen and discusses their chronostratigraphic and cultural stratigraphic context. Archaeologists based at the museum and research institute of Monrepos overlooking the Neuwied Basin excavated most of these sites during the 1980s as part of a major research project exploring the geology and prehistory of the East Eifel. Subse-quently little field work has been conducted on the Middle Paleolithic in the region. The find horizons date to the penultimate and last glaciations and document a wealth of often ephemeral occupations in the craters of the scoria cones. In the case of Wannen, researchers discovered cranial remains of a Neanderthal associated with lithic artifacts in a loess from the penultimate glaciation. The lithic assemblages recovered from the volcanic craters document a high level of technological variability and the use of diverse local and non-local raw materials. While patterns of subsistence varied from site to site, Neanderthals often hunted equids, cervids and bovids in or near the scoria cones. Archaic hominins were likely drawn to the top of these small volcanic mountains to exploit the view they commanded over the landscape and perhaps to use the water that at times collected in these settings. Such water sources may also have attracted game to the top of the scoria cones. While these settings contain numerous Middle Paleolithic find horizons, Upper Paleolithic finds are extremely rare. We hypothesize that the many scoria cones of the Eifel that have not been subjected to large-scale mining also contain similar Middle Paleolithic find horizons, making this prominent feature of the landscape an important part of the Middle Paleolithic settlement dynamics of the region.
Exploring Learner Subpar Performance in Linear Programming at Munkuye Secondary School in Zambia: Hermeneutic Perspective: A Glance on Distance as a Promoter
Authors: Mwambazi Chrispine Mulenga
Published: April 2024

This paper aims to investigate the impact of distance on learners; linear programming performance, employing a qualitative approach. The author argues that effective learning of linear programming requires an accommodation for tardy learners and consideration of their physical distance from school. To reduce absenteeism, math teachers should motivate tardy learners to put extra effort into their studies rather than penalizing them. Additionally, the school administration can arrange transportation for students who face difficulties commuting to class through providing a bus service. Such measures will encourage active participation in class activities and instill positive attitudes towards education among students. Furthermore, relevant parties need to work together to purchase a school bus that facilitates the transportation of learners efficiently. The study concludes by recommending the establishment of more residential schools near communities offering competitive bursaries as it inspires parents and students to support each other.
Contribution of Hepatitis D Virus in Liver Cancer Among Hepatitis B Virus Infected Populations of Central Africa: A Systematic Review and Meta-Analysis
Authors: Henri Mbia Job , Liliane Lebomo Etogo Eugene , Duriannie Njandja Seuyip Darryl
Published: April 2024

Background and aims: Hepatocellular carcinoma (HCC) is a rampant disease in sub-Saharan Africa. Viral hepatitis is currently the most common factor in the occurrence of HCC in sub-Saharan Africa. Hepatitis B virus (HBV) causes liver disease which may or may not progress to HCC. In a dual infection with Hepatitis D virus (HDV), HCC tends to have a faster turn out. Our aim is to evaluate the influence of HDV on the risk of HCC and elaborate on factors favouring HDV infection. Methods: A review of available literature in English or French was conducted in major data bases with the search terms “liver disease”, “hepatocellular carcinoma”, “hepatitis delta and liver disease”, “hepatitis D virus infection”, “prevalence of HDV”, and “hepatitis D in Central Africa”, and each term was associated to a central African country. A meta-analysis of included publications was then performed. Results: The prevalence of HDV was 28% (95% CI). There was a higher risk of HCC in HBV-HDV dual infection (OR: 0.82 [95% CI: -0.01 to 1.65]) compared to that in HBV mono-infection. HDV genotype 1 was found to be the most prominent in central Africa, with HDV subgenotypes 1a and 1b dominating. Hepatitis delta was more prevalent in rural areas than in urban areas. Conclusion: Hepatitis D is highly prevalent in the HBV population of central Africa. The presence of HDV increases the risk of HCC. More research has to be carried out to understand how HDV speeds up liver disease and hence how to prevent it.
OPTIMIZATION IN SYSTEMS ENGINEERING: A REVIEW OF HOW DATA ANALYTICS AND OPTIMIZATION ALGORITHMS ARE APPLIED
Authors: Oladele Junior Adeyeye  , Ibrahim Akanbi
Published: April 2024

This research review article provides a comprehensive examination of optimization techniques in systems engineering, highlighting their pivotal role in enhancing system performance, efficiency, and problem-solving capabilities. Through a structured exploration encompassing theoretical frameworks, methodologies, applications, and significant findings, the article synthesizes current knowledge and advancements in the field. It delves into various optimization methods, including traditional linear and nonlinear programming, alongside emerging trends such as swarm intelligence, nature-inspired algorithms, and the integration of machine learning. Case studies and recent research findings underscore the practical implications and effectiveness of these techniques across diverse engineering challenges. The review identifies key insights, demonstrating the versatility and potential of optimization techniques to drive innovation in systems engineering. Furthermore, it offers recommendations for future research directions and practical applications, emphasizing the importance of interdisciplinary approaches, algorithm development, and the adoption of advanced techniques in industry practices. This article aims to inform researchers and practitioners alike, fostering the continued evolution and application of optimization techniques in systems engineering.

Keywords: Optimization Techniques, Systems Engineering, Swarm Intelligence, Machine Learning, Algorithm Development.
A REVIEW OF DATA-DRIVEN DECISION MAKING IN ENGINEERING MANAGEMENT
Authors: Oladele Junior Adeyeye  , Ibrahim Akanbi
Published: April 2024

This research review article explores the transformative impact of data-driven decision-making (DDDM) across various sectors, highlighting the integration of advanced analytics to enhance organizational efficiency, innovation, and strategic planning. Despite the potential benefits, the adoption of DDDM poses significant challenges, including data quality issues, integration complexities, and the need for a cultural shift towards valuing data analytics. Through a comprehensive analysis of recent research and case studies, this article synthesizes key findings, emerging trends, and future research areas in DDDM. It provides practical recommendations for practitioners aiming to implement and optimize DDDM processes, emphasizing the importance of fostering a data-driven culture, investing in robust data infrastructure, and ensuring the ethical use of data. Additionally, the article offers suggestions for continuous improvement and adaptation to technological advancements, advocating for regular strategy reviews, monitoring emerging trends, and fostering innovation. By addressing these challenges and leveraging the outlined recommendations, organizations can unlock the full potential of DDDM, driving significant advancements in efficiency, competitiveness, and strategic decision-making in the digital age.

Keywords: Data-driven Decision Making, Engineering Management, Machine Learning, Big Data, Advanced Analytics, Organizational Efficiency, Data Quality and Infrastructure, Technological Advancements.
THE FUTURE OF ENGINEERING EDUCATION: A DATA ANALYTICS APPROACH
Authors: Oladele Junior Adeyeye  , Ibrahim Akanbi
Published: April 2024

The landscape of engineering education is undergoing a significant transformation, driven by the integration of data analytics and machine learning (ML) technologies. This paper explores the potential of these technologies to revolutionize engineering education by personalizing learning experiences, predicting student performance, and enhancing curriculum development. Through a comprehensive review of current practices and case studies, we examine the application of data-driven approaches in identifying individual learning patterns, tailoring educational content, and implementing adaptive learning technologies. We also investigate the role of predictive analytics in forecasting academic success and enabling proactive interventions for at-risk students. Furthermore, the paper discusses the challenges and ethical considerations associated with the adoption of these technologies, including data privacy concerns and the digital divide. Our analysis highlights the importance of collaboration among educators, policymakers, and technologists to navigate these challenges and fully realize the benefits of a data-analytics approach in engineering education. The paper concludes with a vision for the future, emphasizing the need for continuous innovation and adaptation in curricula to prepare engineering graduates for the evolving demands of the workforce and society. This investigation sheds light on the transformative potential of data analytics and ML in engineering education and provides a roadmap for its successful integration into teaching and learning processes.

Keywords: Data Analytics, Machine Learning, Personalized Learning, Predictive Analytics, Curriculum Development, Adaptive Learning Technologies, Student Performance Prediction, Technological Integration.
Mobil szociológia?
Authors: Zsinka Flóra
Published: April 2024

A tanulmány célja az új mobilitási paradigma néven ismert interdiszciplináris irányzat bemutatása és kritikai kiértékelése, különös tekintettel arra a programra, amelyet John Urry fogalmazott meg a szociológia megújítása céljából. Urry írásaiban amellett érvel, hogy a 21. században jelentkező olyan tendenciák, mint a technológiai újítások révén egyre fokozódó mobilitás, a növekvő hálózatosodás, hibridizáció és komplexifikáció, indokolttá teszik a korábbi területiség-központú megközelítés felülvizsgálatát, és olyan konceptuális keretek és módszertani eljárások kialakítását, amelyek alkalmasak lehetnek a társadalmi élet átalakuló formáinak tanulmányozására. Jelen írás e program összefoglalását követően először elméleti, majd módszertani szempontból értékeli az Urry és szerzőtársai által javasolt újításokat, azután az irányzat folyóiratában, a Mobilitiesban 2006 és 2023 között megjelent tanulmányok áttekintésével vizsgálja a mobilitási fordulat hatását. A tanulmány mindezek alapján amellett érvel, hogy az új mobilitási paradigma képviselői által kínált elméleti és módszertani megfontolások hiányosságaik ellenére sok tekintetben gazdagíthatják a szociológiai kutatások eszköztárát, és elősegíthetik bizonyos társadalmi jelenségek árnyaltabb értelmezését, de egységes paradigmáról nem beszélhetünk. Az Urry által kidolgozott elméleti szintézis nagymértékben épít más szerzők műveire, és úgy tűnik, hogy a megközelítés újdonsága sok esetben inkább az általa hivatkozott elméletek sajátja. A vizsgált folyóiratcikkek alapján arra lehet következtetni, hogy Urry elméleti-módszertani programja a kritikai mobilitáskutatás területén sem vált egységesen elfogadott értelemzési keretté.
TRANSTORNOS NA INFÂNCIA E COMO MELHORAR A INTERAÇÃO DESSAS CRIANÇAS
Authors: Silveira Luciana Thaís Gomes Cordeiro da , Pinho Nayara Gonçalves de
Published: April 2024

O presente trabalho abordou estratégias para melhorar a interação social e emocional de crianças com transtornos na infância. Discutiu-se a importância de reconhecer e valorizar as habilidades e interesses individuais das crianças, destacando como isso pode promover sua autoestima e motivação para se envolver em interações sociais. Estratégias como a criação de ambientes estruturados, o ensino de habilidades sociais específicas e a promoção da inclusão em atividades sociais foram exploradas em detalhes, enfatizando a necessidade de uma abordagem individualizada e adaptada às necessidades de cada criança. Além disso, ressaltou-se o papel crucial dos pais, escola e profissionais de saúde na promoção do desenvolvimento social e emocional das crianças, enfatizando a importância da colaboração entre esses diferentes atores. Por fim, foram discutidos desafios futuros e perspectivas, destacando a importância contínua da pesquisa e do investimento em serviços de saúde mental e educação especial.
ANÁLISE DO POTENCIAL EÓLICO NA REGIÃO SUL DO BRASIL
Authors: Ganem Marcelo Alvinho Sanjuan Dias
Published: April 2024

O objetivo do trabalho a seguir é a determinação do potencial eólico da região Sul do Brasil a partir do levantamento de dados, que foram obtidos por meio do Operador Nacional do Sistema Elétrico (ONS), pela Agência Nacional de Energia Elétrica (ANEEL) e Atlas de Potencial Eólico disponíveis. A análise foi desenvolvida baseando-se em dados consolidados em pesquisas realizadas por instituições da região sul, que, junto com o governo dos estados da região, buscam alavancar a geração eólica como fonte determinante na matriz energética dos estados do Paraná, Santa Catarina e Rio Grande do Sul.
FORMAÇÃO DE PROFESSORES DE MATEMÁTICA: O PAPEL DA PSICOLOGIA DO AFETO E DO LÚDICO NO PROCESSO DE ENSINO-APRENDIZAGEM
Authors: Silva Lilian Maria Santos da , Leal Débora Araújo , Melo Márcia Colaço Ferreira de , Tourinho Cleber , Melo Agnaldo Ferreira de
Published: April 2024

Este trabalho aborda a importância da integração entre estratégias lúdicas e o aspecto afetivo no ensino da Matemática, visando promover um ambiente de aprendizagem mais acolhedor e estimulante. Destaca-se a necessidade de uma formação de professores que vá além da simples transmissão de conhecimento, abrangendo habilidades pedagógicas sólidas e compreensão das teorias de aprendizagem. A metodologia se baseia numa revisão narrativa de literatura, envolvendo a análise de pesquisas que demonstram a eficácia do uso de jogos, atividades lúdicas e estratégias baseadas na Psicologia do Afeto para promover a motivação, engajamento e bem-estar emocional dos alunos. Além disso, ressalta-se a importância da formação contínua dos professores, permitindo que se mantenham atualizados sobre as tendências e metodologias de ensino. O texto enfatiza que, ao criar um ambiente emocionalmente seguro e motivador na sala de aula, os professores podem influenciar positivamente o processo de aprendizagem e o desenvolvimento integral dos alunos. Conclui-se que a formação do professor de Matemática não apenas impacta a qualidade da educação, mas também contribui para a construção de uma sociedade mais competente em relação aos desafios matemáticos contemporâneos.
Nota editorial: desafíos del derecho en el Siglo XXI
Authors: Tejeiro Duque Octavio Augusto
Published: April 2024

Esta publicación constituye un aporte de quienes se atreven a exponer sus reflexiones en busca de las soluciones que el derecho debe ir encontrando.
Un relato del trabajo de campo en el ETCR Mariana Páez.
Authors: Scolaro Feijóo Florencia
Published: April 2024

Llegué a UNIMETA, en el marco de una beca de estancia de investigación con el fin de concluir las entrevistas para la tesis doctoral que estoy llevando a cabo. La investigación consiste en desarrollar un análisis de las memorias de mujeres firmantes de la paz a partir de sus experiencias en el marco del conflicto armado, poniendo en consideración el binomio guerra/paz, es decir, sus experiencias en el marco de la guerrilla y durante el postacuerdo.
La proyección social en los programas académicos de derecho
Authors: Cárdenas Moreno María Alejandra
Published: April 2024

Cuando hablamos de Instituciones de Educación Superior (IES), inmediatamente nos vienen a la mente dos funciones principales relacionadas con la docencia y la investigación. En el imaginario de nuestra sociedad, una IES está establecida para (i) enseñar en los espacios de aprendizaje y para desarrollar proyectos de investigación, cuyos resultados son de interés de una minúscula comunidad científica. No obstante, todas aquellas instituciones que obtienen el registro calificado por parte del Ministerio de Educación para impartir cualquier programa académico de formación profesional deben ejercer como función sustantiva, además de la docencia y la investigación, una muy importante: la proyección social.
Ontología política de los derechos de la naturaleza en el Nuevo Constitucionalismo Latinoamericano
Authors: Duque Acosta Carlos Andrés
Published: April 2024

Este trabajo expone una reflexión en torno a los derechos de la naturaleza o Madre Tierra en el marco del Nuevo Constitucionalismo Latinoamericano (NCL), en especial, respecto al proceso constituyente del Ecuador (2008) y Bolivia (2009), desde la perspectiva de la ontología política. Se argumenta que los avances jurídico-políticos del NCL se conectan con los procesos históricos de descolonización del continente y la construcción de otros mundos posibles que den respuesta a la crisis multidimensional global que hoy enfrenta la humanidad ubicándola en el horizonte de la auto-extinción.
Habilidades terapéuticas en logopedia: punto de vista de profesionales y pacientes
Authors: Calabuig-Sanfeliu Beatriz , Cervera-Mérida José Francisco , Ygual-Fernández Amparo
Published: April 2024

Las profesiones sanitarias evolucionan hacia un Modelo Clínico Centrado en el Paciente, heredero del modelo biopsicosocial, caracterizado por su comprensión holística, la relación de ayuda y la toma de decisiones compartidas. Este modelo requiere que los profesionales dispongan de habilidades terapéuticas que favorezcan la relación y el bienestar subjetivo del paciente. Nuestro estudio investiga las opiniones de logopedas y pacientes sobre el papel de estas habilidades, cuál consideran la más importante y cómo influye la experiencia laboral en sus percepciones. En este estudio tomaron parte 558 personas divididas en dos grupos: Profesionales y Pacientes-Familiares. Los datos se recabaron con formularios separados para logopedas y pacientes. Se compararon las respuestas de los grupos y se correlacionó con la experiencia profesional. los pacientes valoran las habilidades terapéuticas por encima de conocimientos y experiencia. Los profesionales otorgan más importancia a los conocimientos a medida que aumentan experiencia y toman sus decisiones en función de las pruebas o de su propio criterio, antes que en un intercambio de información con el paciente. La habilidad terapéutica más valorada por ambos grupos es la empatía y esta apreciación crece conforme aumenta la experiencia. Los pacientes vinculan la excelencia del profesional a sus habilidades terapéuticas. Los pacientes otorgan el máximo valor a las habilidades terapéuticas y los logopedas les confieren un papel muy importante, equiparándolas a los conocimientos. Estos resultados soportan la idea de que los logopedas han asumido el modelo biopsicosocial, pero no confirman que apliquen la Toma de Decisiones Compartidas, núcleo del Modelo Clínico Centrado en el Paciente.
The Investigation of the Untapped Winemaking Potential of the Grape Variety “Hastakot”
Authors: Gabrielyan A.H. , Iskandaryan G.B.
Published: April 2024

Research works demonstrate a rising demand for high-quality wine in Armenia. Our objective was to produce premium red and rosé wines using the relatively unexplored grape variety “Hastakot”. Throughout the research, we utilized various winemaking technologies to produce red and rosé wines of the grape variety “Hastakot”. Simultaneously, multiple physicochemical and sensory attributes were investigated in the produced must and wine. The obtained results highlight the ability to make unique wines from the grape variety “Hastakot”, indicating a potential market impact and gaining consumer appreciation.
Garbage to Beauty: Development and In-Vitro Evaluation of Antioxidant Rich Microsponge Sunscreen Lotion from Fish Scale and Mango Kernels
Authors: K Raslamol , V Babu Alvina , K U Anjali Krishna
Published: April 2024

This study aims to develop and assess a herbal sunscreen formulation for skin protection against sun damage, utilizing ingredients from plant extracts such as Mangifera indica (mango seed kernels) and animal extract from Sardinella longiceps (pearl essence extracted from fish scales). Mango seed kernels, known for their high stability and antioxidant activity, offer a valuable commodity by repurposing waste. The pearl essence, derived from fish scales, contains guanine, an iridescent substance found in the epidermal layer and scales.
The herbal sunscreen formulation incorporates fixed oils, medicinal plants, and animal materials. Mango seed kernels are extracted using a soxhlet apparatus, while pearl essence is obtained through a solvent diffusion method. Regular use of sunscreen has been shown to reduce the development of actinic keratosis, squamous cell carcinoma, and melanoma by absorbing or reflecting the sun's ultraviolet radiation, protecting the skin. The escalating incidence of skin cancers and the detrimental effects of ultraviolet radiation have amplified the use of sunscreening agents, demonstrating their efficacy in mitigating symptoms.
The prepared sunscreen, enriched with mango kernel extract and pearl essence, as well as curcumin microsponge, offers a multifaceted sunblocking action due to high antioxidant activity and imparts a shimmering effect on the skin. The inclusion of curcumin microsponge aids in the penetration of the lotion into the skin, ensuring a comprehensive effect. Evaluation of the sunscreen lotion encompassed parameters such as pH, viscosity, spreadability, and stability, confirming the safety of the herbal sunscreen for skin use.

Key words: Herbal sunscreen, Mango kernal, Pearl essence, Microsponge drug delivery system, Antioxidant activity.
Cushing’s Syndrome Secondary to Steroid Abuse
Authors: Enekole Aitafo Josephine , Imafidon Sotonye Peace , Onubogu Uchenna
Published: April 2024

Introduction: Cushing’s syndrome, a rare endocrine disorder may result from exogenous administration of steroids.
Case Report: E.P, 4 years old female presented to RSUTH at 3 years 7 months with complaints of speech delay and difficulty standing from sitting position. She had left convergent squint, Grade 3/6 systolic murmur and proximal muscle weakness. Initial diagnosis was ‘Duchenne muscular dystrophy and Acyanotic congenital heart disease’. Echocardiography revealed Atrial and Ventricular Septal Defects. Creatine kinase was normal. She was placed on tabs prednisolone, furosemide, spironolactone and physiotherapy; counselled and booked for follow-up in 2 weeks.
She defaulted from follow-up and continued to give Prednisolone. Five months later, she presented to the Cardiology clinic with excessive weight gain and breast development. She had moon face, truncal obesity, and elevated BP. She was referred to the Endocrinology clinic where, in addition, cushingoid appearance, hirsutism, acanthosis nigracans, a hump, striae, with a left convergent squint were noted. Breast was Tanner stage 2. Diagnosis was Cushing’s syndrome secondary to Steroid Abuse, Stage 2 hypertension, Premature thelarche? Diabetes mellitus? Pituitary tumour. Brain MRI and abdominal USS were normal. HbA1c was elevated, insulin, C-peptide and Adrenocorticotropic hormone (ACTH) levels were reduced. Other hormonal indices were normal. She was given tabs Amlodipine and Prednisolone stopped. She steadily improved. Six months later, her blood pressure and sugar had normalized.
Conclusion: Cushing’s syndrome though rare may occur secondary to steroid abuse. Strict compliance to doctor’s prescription and follow up cannot be over emphasized.

Key words: Cushing’s, Syndrome, Steroid, Abuse
A Case of Emergency Caesarean Section in Patient with Large Atrial Septal Defect with Severe Pulmonary Arterial Hypertension
Authors: Venkataramana Dr Shivanna , S Dr Shilpa
Published: April 2024

Pregnancy with pulmonary hypertension carries a very high risk of morbidity and mortality and therefore women with severe pulmonary hypertension are advised not to become pregnant. However, many women with severe pulmonary hypertension become pregnant and present with complications. Here we present successful management of a patient with severe pulmonary hypertension presented for emergency caesarean section under epidural anaesthesia.

Key words: pulmonary arterial hypertension (PAH), atrial septal defect (ASD), pregnancy, epidural anaesthesia.
Effect of Scalene and Pectoralis Minor Stretching Exercises in Patients with Carpal Tunnel Syndrome: A Case Series
Authors: Soni Aasha , Mehra Suman , Dabla Surekha
Published: April 2024

Introduction- Carpal tunnel syndrome (CTS) is considered the most common peripheral entrapment neuropathy, which manifests as unpleasant symptoms, such as burning, tingling, or numbness in the palm that extends to the fingers. As the disease progresses, individuals also report decreased grip strength accompanied by hand weakness and atrophy of thenar muscles and hence affects the activities of daily living of the patients. There are both surgical and conservative treatments available for relieving strain on the median nerve.
Purpose- To find out the effect of scalene and pectoralis minor muscles stretching exercises on pain intensity, symptoms severity and functional status in patients with CTS
Methodology- In this case series 5 diagnosed cases of CTS had undergone scalene and pectoralis minor muscles stretching exercises along with conventional treatment which included median nerve mobilization, flexor tendon gliding exercises. Treatment was given 3 times in a week for 4 weeks. Outcome measures were pain intensity, symptoms severity and functional status of hand.
Result & conclusion- There was significant reduction in pain, symptoms severity and also significant improvement in functional status of the hand in all 5 patients.

Key words: Carpal Tunnel Syndrome, Tendon Gliding exercises, Splinting, Pain, Median Nerve Gliding exercises.
Prevalence of Disability in Food Delivery Boys with Chronic Occupational Low Back Pain - An Observational Study
Authors: Chavan Sanskruti , Jain Sonam
Published: April 2024

Introduction: Due to rapid urbanization, the work of food delivery boys is tremendously increasing, leading to an increased prevalence of low back pain in them. This low back pain may eventually lead to temporary or permanent disability. Thus, the need of the study was to understand the prevalence of the disability due to chronic occupational low back pain which may occur in this population.
Aim: To find the prevalence of disability in food delivery boys with chronic occupational low back pain.
Objectives: To determine the prevalence of disability in food delivery boys with chronic low back pain using the Oswestry low back disability questionnaire.
Methods: An observational study was conducted with 361 food delivery boys, aged 30-40 years, complaining of low back pain for more than 6 months. Only males who could read and understand English and who traveled for at least 6 hours a day were included in the study. The ones who had spinal deformities, any recent fractures, neurological disorders, or recent soft tissue or ligament injuries around the spine were excluded from the study. Food delivery boys who were involved in any other occupation were also excluded.
Results: The average hours of riding the bike have been reported as 10.96 hours/day with an average distance of 141.69 kilometers daily. The average score on the Oswestry low back disability questionnaire was 8.63, accounting for 18.64% disability i.e. Minimal disability.
Conclusion: This study concluded that the prevalence of disability in food delivery boys having chronic occupational low back pain is 64% indicating Minimal and 36% indicating Moderate disability.

Key words: Chronic occupational low back pain, Disability, Food delivery boys, Oswestry disability index.
Adenovirus-Induced Intussusception in a 3-Year-Old Patient: A Case Report and Review of the Literature
Authors: Dohadwala Taha Kassim , Siradze Nino , Mikeladze Aleksandre
Published: April 2024

Intussusception is characterised by invagination of the proximal bowel segment into the lumen of a distal segment leading to acute bowel obstruction. In the pediatric population, idiopathic ileocolic intussusception is the most common form with a small subset of the patient's presenting with concurrent adenovirus infection. We present a rare case of adenovirus-induced intussusception in a pediatric patient, highlighting the potential association of viral factors and GI conditions.
Three y/o male presents’ with a 3-day history of fever, vomiting and colicky abdominal pain. Imaging tests revealed characteristic “target sign” which along with the presenting symptoms confirmed the diagnosis of ileocolic intussusception. Due to the persistence and severity of the patient's symptoms, surgical intervention was undertaken to relieve the obstruction and a subsequent PCR confirmed concurrent adenovirus infection.
Although a causative factor for only a subset of pediatric intussusception cases, it remains necessary nevertheless to understand the pathogenesis and raise awareness among healthcare workers of the potential link between adenovirus infection and intussusception in the pediatric population.

Key words: Intussusception, Target sign, Surgical Intervention, PCR, Adenovirus.
Analysis of the effectiveness of freelance exchanges and their demand among corporate customers in the context of tax regulation
Authors: Rexhepi Burhan Reshat , Daci Enver , Mustafa Labeat , Berisha Burim Isa
Published: April 2024

The relevance of the study is conditioned by the dynamic development of the freelance market and the prospects for cooperation between freelancers and corporations, considering the specifics of taxation of such labour relations. The paper examines the essence of the concepts of “freelancer” and “freelance exchange” and substantiates the reasons for the establishment and popularisation of freelancing in modern conditions. The freelance markets of the countries of the Balkan Peninsula and Ukraine were analysed in terms of supply and demand, the number of vacant projects, the cost that the customer is willing to pay for the completed project. The purpose of this study is to analyse the actual performance indicators of existing freelance exchanges and assess the prospects for cooperation between corporations and freelance employees in the context of the possibility of optimising the taxation of legal entities. The methodological basis of the study was the use of system analysis in evaluating the results of freelance exchanges and attracting and cooperating with corporate clients, theoretical data on further prospects for using online labour exchanges by enterprises to attract the contractor of project work were highlighted. The advantages and disadvantages of cooperation in the customer-contractor field on the online labour exchange in the context of financial aspects are summarised. The relevance of the further study of the development processes of freelance exchanges, due to their growing popularity among employers, is substantiated. The study results and the conclusions formulated on their basis are of significant importance for the management level of companies, since based on the conducted research and already existing analytical information, the effectiveness of attracting freelance employees through freelance exchanges, the possibility of reducing the company’s labour costs and optimising the tax burden in terms of paying taxes for an employee has been confirmed
Antibiotic resistance of conditionally pathogenic Enterobacteriaceae strains causing acute diarrhoea diseases
Authors: Guţu Nadejda , Rudic Valeriu
Published: April 2024

Acute diarrheal disease presents a major public health problem, and the identification of pathogens serves both to identify the sources of spread of infections and to establish the correct treatment. In this context, the aim of this research was to detect the conditionally pathogenic agents from the Enterobacteriaceae family, which cause more frequently acute diarrheal diseases, and to test their sensitivity to antibiotics. The research was carried out during 2019–2022 within the Public Health Medical Institution TMA Buiucani, mun. Chișinău. 537 strains were isolated and eight conditionally pathogenic agents from the Enterobacteriaceae family were identified. During the study period, a slow decrease in the values of the quantitative indices of the conditional pathogenic agents was observed, the etiological spectrum was dominated by Klebsiella spp. (43,58 %). Conditionally pathogenic agents have registered a different degree of resistance to antibiotics, which underlines the importance of an antibiogram for the effectiveness of the therapy. A very high resistance was recorded to the penicillin. The results obtained during the study period reveal the importance of monitoring the antibiotic resistance, which is very significant in the treatment of acute diarrheal diseases.
The agroecological potential of clones of Merlot variety
Authors: Voinesco Cornelia
Published: April 2024

The research presented in this article consists in studying the agroecological potential of the clones of Merlot wine variety (cl. 181, cl. 343, cl. 347, cl. 348, cl. 349) under the conditions of the Mereni wine-growing center, Codru region. The climate changes of recent years have brought more and more challenges to the farmers to study and better understand how high temperatures affect the vine and not only. Increasing variety diversity is an important task that involves both enhancing the quality of selection and improving the varieties themselves. This study presents the results of a research on a series of clones of Merlot grape variety. The evolution of the main phenological phases of the vine vegetation cycle was directly influenced by the climatic, pedological and topographical conditions of the area. Based on the study, it was found that in the conditions of the Mereni wine-growing area, the Codru Region, the mentioned clones of Merlot wine variety recorded a various level of significance of the difference in the values of the analyzed characters, depending on the year and the clone. The Merlot cl. 347 showed a maximum harvest of 18.08 t/ha. The Merlot cl. 348 showed a maximum sugar content of 264.5 g/dm3. The Merlot cl. 347 showed a minimum content of titratable acidity of 8.32 g/dm3.
Academician Vasile Micu (1938–2019), famous scientist and man of culture
Authors: Rotaru Tatiana , Micu Svetlana
Published: April 2024

The study is dedicated to the research activity of the academician Vasile Micu, a remarkable personality in the history of Romanian science and culture, and his contribution to the development of agricultural sciences in the Moldavian SSR and the Republic of Moldova. He was the founder of the scientific school of corn genetics and improvement in the Republic of Moldova, author of more than 100 corn hybrids approved in seven countries, which are grown annually on extensive areas (over 55-60 million hectares in total); co-author of 39 varieties of aromatic and medicinal plants, included in the Register of Plant Varieties of the Republic of Moldova, author of over 250 scientific works, including 4 monographic studies. He exercised important scientific and managerial functions, including director of the Scientific Research Institute for Maize and Sorghum of AŞP "Hybrid" and general director of AŞP "Porumbeni" (1986–2008), later reorganized into the "Porumbeni" Institute of Phytotechnology.
Terms and concepts related to the diachronic-ontological approach of reading by Alberto Manguel
Authors: Pâslaru Vlad
Published: April 2024

The study “follows the author” in building a synthesis of the reading concepts revealed historically in an essayistic stylistic key by Alberto Manguel (b. 1948, Argentina). More or less sufficiently examined by modern literary theory, Manguel (Istoria lecturii –The history of lecture, Bucharest: Orion (Nemira), 2022) gives the concepts of reading not only a narrative-diachronic vision, but also a philosophical-artistic depth, his vision shining a light on the thicket of terms in which the essence of reading is often hidden in theory literary studies. Since literary theory investigates the visible - the text and the message, from which it assembles an abstract, virtual reader, and Manguel discovers the very nature of reading, the primordial importance of reading-writing for the becoming of man in his own cultural-spiritual being. . After nature, reading is the second existence of the human being, respectively, an essential necessity for his education as a being that coexists in nature and in culture. Reading makes man a transcendental being. Reading makes the man a transcendental being. Reading is the creator of the man and all his activities that continually build him culturally. Or, precisely in this context, reading is also examined by the theory of literary-artistic education, which Manguel’s diachronicphilosophical vision ennobles on the epistemic side.
Digital competences in terms of socio-cultural education
Authors: Danila Victoria
Published: April 2024

The purpose of this paper is to present a model for the digital culture development of the students from the International Free University, the Computer Graphics Programming specialty, second year, first cycle, bachelor's degree. The results of the study carried out during the classes using programs and information technologies according to the digital skills training program are analyzed. The study focused on the development of sociocultural values, essential for the growth and training of young people as qualified personalities and specialists. Digital skills are not only the core of students' digital culture, but a complex, interdisciplinary phenomenon, therefore requiring a comprehensive analysis through the prism of different fields of science (philosophy, sociology, psychology, pedagogy, study of arts). Values of digital culture are indispensable for organizing social and cultural activities within society, promoting the products of non-commercial organizations, etc. The work capitalizes on the idea of students` collaboration and motivation in the development of fundamental products through digital tools in the teaching-learning-evaluation process.
The village as a source of inspiration in Sergiu Galben's painting
Authors: Toma Ludmila
Published: April 2024

The article highlights the creative originality of Sergiu Galben, a prominent representative of Moldavian fine arts from the second half of the 20th century – the beginning of the 21st century. His works, varied in terms of motifs and expressive means, impress with the author’s emotional openness, suggest his harmonious connection with the universe of nature, his love for his native land. The artist is emotionally close to the environment of working people from the countryside, which he paints based on the well-assimilated European plastic culture.
Design, Synthesis and Anticancer Activity of Substituted
1, 3-Thiazolidin-4-One Derivatives
Authors: Barkade Ganesh D. , Sawant Ramesh L.
Published: April 2024

Background: Cancer is the global cause of death worldwide. Anticancer drug development is the need in today’s scenario. Thiazolidine is the nucleus that shows several pharmacological activities like anticancer, anti-inflammatory, antioxidant, antibacterial, antifungal, antidiabetic, antihyperlipidemic, and antiarthritic activity. In the present work molecular docking Glide module (Schrodinger Inc., USA) has been used for ligand docking against the Polo-like kinase-1. The series of substituted 3-Benzothiazol-2-yl-2-phenyl)-thiazolidin-4-ones were synthesized by the microwave-assisted synthesis system (CEM, USA) and characterized by melting point, FT-IR, 1H NMR, 13C NMR, and HR-MS analysis. Results: Molecular docking studies shows good docking score as well as interactions. Among the synthesized compounds, BG2 had the highest docking score of -8.381, followed by BG8 (-8.19) and BG1 (-8.156). All the newly synthesized compounds were examined for their in vitro anticancer activity against breast cancer cell line MCF-7 by Sulforhodamine B (SRB) assay. Conclusion: BG1, BG2, BG3, BG4, BG5, BG8, BG9, BG10, BG11, BG12, and BG13 (GI50: <80 µg/ml) exhibited significant cell growth inhibitory activity. These results indicate that compounds showing in-vitro activity by molecular docking studies and SRB assay could be lead compounds for further development of anticancer agents and suitable candidates for in-vivo anticancer activity.
Phyto-Morphological and Phytochemical Insights: A Comprehensive Study of Hygrophila triflora (Roxb.) Fosb. and Sachet Leaves
Authors: Sahu Dipsundar , Dutta Sreya , Bhushan Shakti , Das Manosi , Mondal Susmita , Babu G.
Published: April 2024

Hygrophila triflora (Roxb.) Fosb. and Sachet, a notable member of the Acanthaceae family, is a herbaceous plant indigenous to South Asia, commonly found along watercourses. This study delves into the taxonomic history, morphological diversity, ecological relevance, and physicochemical properties of Hygrophila triflora. Morphologically, the plant displays dimorphism in its leaves, with adaptations suited for both aquatic and terrestrial environments. Leaves were collected from Baruipur, West Bengal, and authenticated, followed by a series of processing and microscopic analyses to explore the plant's anatomical features. The physicochemical evaluations highlighted properties such as moisture content, ash values, and extractive values, establishing a foundation for the plant's quality assessment. High-Performance Thin Layer Chromatography (HPTLC) was employed to derive a comprehensive phytochemical profile, revealing distinct Rf values when observed at two wavelengths, 254 nm and 366 nm. Additionally, a qualitative analysis showcased the presence of various secondary metabolites, such as alkaloids and flavonoids, in different extracts of the plant. These findings contribute valuable insights into the anatomical, chemical, and potential therapeutic attributes of Hygrophila triflora, paving the way for deeper pharmacological investigations and potential applications in traditional and modern medicine. This research underscores the importance of continued exploration of indigenous plant species, elucidating their roles in ecosystems and potential contributions to scientific and therapeutic domains.
MTT Assay on Anticancer properties of the different extracts of roots of Lantana camara Linn.
Authors: Ali Ashraf , Malipatil Malikarjun , Ahmed Layikh
Published: April 2024

Lantana camara, considered a weed is an evergreen plant found throughout the world. Traditionally it has been used in the treatment of various ailments and has been supported by scientific investigation. Phytoconstituents present in almost all parts of this plant have been reported in various literature. This study has been done on the root part of Lantana camara, the dried and powdered root was subjected to continuous solvent extraction with Hexane followed by Ethyl Acetate and Methanol. Ethyl Acetate and Methanol extracts were evaluated for anticancer activity by MTT assay, MCF7 cell line was used with Cisplatin a known anti-cancer drug as a standard reference, and the measurements were carried out at wavelengths 570 and 630nm. The percentage of growth inhibition was calculated. The concentration of test extract needed to inhibit cell growth by 50% (IC50) value generated from the dose-response curve. IC50 values of Ethyl Acetate extract were greater than 500µg/ml and Methanol extract 450.05µg/ml.
Tyrosinase Inhibitory Activity of n-Hexane, Ethyl Acetate and Methanol Extracts of Padina sp
Authors: Akbar Andi , Rasyid Herlina , Natsir Hasnah , Bahrun Bahrun , Soekamto Nunuk Hariani
Published: April 2024

Melanin is a color pigment in the skin, if produced in excess will cause browning of the skin. The formation of melanin (melanogenesis) is assisted by tyrosinase through two reactions, namely monophenolase and diphenolase. Melanogenesis can be reduced through the tyrosinase enzyme inhibition mechanism. Seaweed can be used as a tyrosinase inhibitor (brightening agent), such as Padina sp containing secondary metabolites such as alkaloids, flavonoids, terpenoids, phenolics, and saponins. This study aimed to determine the tyrosinase inhibitory activity of Padina sp. The extraction method used was graded maceration with n-hexane (n-Hx), ethyl acetate (Et-OAc), and methanol (Me-OH) solvents, then carried out phytochemical screening, antioxidant test using the DPPH method, and tyrosinase inhibitory test by measuring the enzymatic reaction using L-tyrosine (monophenolase) and L-DOPA (diphenolase). Phytochemical analysis of extracts by GC-MS and in silico analysis by molecular docking were also carried out. The results showed that the total yield of the three extracts was 5.50%. The three extracts had moderate category of antioxidants. The IC50 values monophenolase of n-Hx, Et-OAc, Me-OH extracts, and Kojic acid were 937.68; 132, 92; 268.68; and 20.99μg/mL, respectively. The IC50 values diphenolase of n-Hx, Et-OAc, Me-OH extracts, and Kojic acid were 989.74; 178.33; 356, 87; and 31.76 μg/mL, respectively. The phytochemical of Et-OAc extract based on GC-MS data showed a variety of compounds that have been shown to have pharmacological effects. This data is supported by the results of molecular docking analysis, where compound Spiro(tetrahydrofuryl)2.1'(decalin), 5',5',8'a-trimethyl (1) is able to show a relatively low binding energy, namely -6.86 kcal/mol. The binding energy is even lower than the standard compound (Kojic acid) interaction which only has binding energy of -3.73 kcal/mol. Based on the study carried out, extract from Padina sp has the potential to be developed as a a skin brightening agent.