bluuebunny/crossref_metadata_2025 huggingface dataset:
Nesting in the City: Urban Environment That Invites Wildlife
Authors: Khaleque Tanjina
Published: November 2021

This study explores how important it is to keep the ecosystem in balance, maintaining healthy biodiversity in urban areas. It also seeks ways in which a growing metropolitan like Dhaka can be friendly for wildlife. Modern cities are becoming more and more hostile to fauna which eventually affects humans also. The damage done over decades cannot be rectified overnight. The approach will be in different phases that address ecological succession. The paper suggests ways urban design can aid biodiversity. A minor consideration as the introduction of nectar-producing plants may increase the honeybee population. The urban landscape should be such that it favors insects or birds. To achieve this, complementary plants should be selected that can nurture an ecosystem.This research looks for options that can be applied in Dhaka’s context. The symbiosis between native wildlife and humans is studied. Exemplary design solutions for urban built areas as flyovers, bus stops or road medians are proposed.
Ancestral architecture of Malocas, impact in communities in the ancestral people for tourism. Shuar ecuadorian Community Case study
Authors: Angulo Alicia Porras , Freire Alba Hernández , Angulo Vinicio Porras
Published: November 2021

The article presents information about ancestral indigenous ethno-knowledge of the indigenous community Shuar; the data was collected through participatory workshops, interviews and expeditions in order to collect plant species, and identify them in situ, always accompanied by local people considered them with experience and knowledge of their territory, this plants are important in the  indigenous population and tourists that visit the community because the ancestral architecture that they have its important for the tourism and design of Malocas or ancestral community tourist houses with low environmental impact and improved the ceremony and the intercultural connection between the shaman who has the ancestral heritage.
Enhanced degradation of phenol by a novel biomaterial through the immobilization of bacteria on cationic straw
Authors: Liang Jing , Gong Shuxin , Sun Yuanhan , Zhang Jiejing , Zhang Jianfeng
Published: November 2021

As phenol possesses a threat to human health, there is a great demand to search for fast and efficient methods for it to be discharged. In this study, a novel biomaterial was prepared by the immobilization of bacteria on a cationic straw carrier, and the remediation ability of the biomaterial on phenol-containing wastewater was investigated. The free bacteria could degrade 1,000 mg/L phenol within 240 h, while the prepared biomaterial was 192 h, shortening by 48 h that of free bacteria. In addition, the degradation tolerance of biomaterial increased from 1,000 mg/L to 1,200 mg/L than the free bacteria, within 216 h, which shortened by 24 h the degradation time of 1,000 mg/L phenol by free bacteria (240 h). Further, under different pH conditions, the degradation efficiency of phenol by prepared biomaterial was much higher than that of free bacteria. Especially for the lower pH 5, the degradation efficiency of biomaterial was nearly twice that of the free bacteria. This investigation demonstrates that this biomaterial has great potential in the field of remediation of organic pollution.
Emerging and New Treatment Options for Knee Osteoarthritis
Authors: Siddiq Md. Abu Bakar , Clegg Danny , Jansen Tim L. , Rasker Johannes J.
Published: November 2021

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Osteoarthritis (OA) is the most prevalent type of arthritis worldwide, resulting in pain and often chronic disability and a significant burden on healthcare systems globally. Non-steroidal anti-inflammatory drugs (NSAIDs), analgesics, intra-articular corticosteroid injections are of little value in the long term, and opioids may have ominous consequences. Radiotherapy of knee OA has no added value. Physical therapy, exercises, weight loss, and lifestyle modifications may give pain relief, improve physical functioning and quality of life. However, none of them has articular cartilage regenerating potential. Due to a better understanding of osteoarthritis, innovative new treatment options have been developed. In this narrative review, we focus on emerging OA knee treatments, relieving symptoms, and regenerating damaged articular cartilage that includes intra-articular human serum albumin, conventional disease-modifying anti-rheumatic drugs (DMARDs), metformin, lipid-lowering agents (statin), nerve growth factors antagonists, bone morphogenetic protein, fibroblast growth factors, Platelet-Rich Plasma (PRP), Mesenchymal Stem Cells (MSC), exosomes, interleukin-1 blockers, gene-based therapy, and bisphosphonate.
Ukrainian Translation and Linguistic Validation of the Gender Bias Quiz Questionnaire
Authors: Kostina Tetiana , Drozdova Diana , Bulakh Iryna
Published: November 2021

This work aims to confirm the Ukrainian variant of the Gender Bias Quiz at a linguistic level. Thе questionnaire consists of 20 questions, which allows the psychologist to determine the individual's gender bias. Respondents (university students, 20-26 years old) completed the Ukrainian translated version of the Gender Bias Quiz questionnaire, and then two weeks later, students completed the original one. Statistical analysis of the data included the use of the Wilcoxon test and the Spearman correlation test. The Wilcoxon test results showed no significant differences between the original (English) and the translated questionnaire. Instead, the Spearman test showed a positive correlation at a high level of statistical significance between respondents' scores in the first and second tests. The obtained data proved the successful linguistic validation of this questionnaire.
Repercussions of COVID-19 on the Indian stock market
Authors: Ashri Dhananjay , Sahoo Bibhu Prasad , Gulati Ankita , Haq Irfan UL
Published: November 2021

The present paper determines the repercussions of the coronavirus on the Indian financial markets by taking the eight sectoral indices into account. By taking the sectoral indices into account, the study deduces the impact of virus outbreak on the various sectoral indices of the Indian stock market. Employing Welch's t-test and Non-parametric Mann-Whitney U test, we empirically analysed the daily returns of eight sectoral indices: Nifty Auto, Nifty FMCG, Nifty IT, Nifty Media, Nifty Metal, Nifty Oil and Gas, Nifty Pharma, and Nifty Bank. The results unveiled that pandemic had a negative impact on the automobile, FMCG, pharmaceuticals, and oil and gas sectors in the short run. In the long run, automobile, oil and gas, metals, and the banking sector have suffered enormously. The results further unveiled that no selected indices underperformed the domestic average, except NIFTY Auto.
Identification of the Most Suitable App to Support the Self-Management of Hypertension: Systematic Selection Approach and Qualitative Study
Authors: Alessa Tourkiah , Hawley Mark , de Witte Luc
Published: November 2021

Background

Smartphone apps are increasingly being used to aid in hypertension self-management, and a large and ever-growing number of self-management apps have been commercially released. However, very few of these are potentially effective and secure, and researchers have yet to establish the suitability of specific hypertension apps to particular contexts.

Objective

The aim of this study is to identify the most suitable hypertension app in the context of Saudi Arabia and its health system.

Methods

This study used a 2-stage approach to selecting the most suitable app for hypertension self-management. First, a systematic selection approach was followed to identify a shortlist of the most suitable apps according to the criteria of potential effectiveness, theoretical underpinning, and privacy and security. Second, an exploratory qualitative study was conducted to select the most suitable from the shortlist: 12 doctors were interviewed, and 22 patients participated in 4 focus groups. These explored participants’ attitudes towards self-management apps in general, and their views towards the apps identified via the systematic selection process. The qualitative data were analyzed using framework analysis.

Results

In the first stage, only 5 apps were found to be potentially effective while also having a theoretical underpinning and protecting users’ data. In the second stage, both doctors and patients were generally interested in using hypertension apps, but most had no experience with these apps due to a lack of awareness of their availability and suitability. Patients and doctors liked apps that combine intuitive interfaces with a pleasant and clear visual design, in-depth features (eg, color-coded feedback accompanied with textual explanations), activity-specific reminders, and educational content regarding hypertension and potential complications. When the pros and cons of the 5 apps were discussed, 3 apps were identified as being more suitable, with Cora Health rated the highest by the participants.

Conclusions

Only 5 apps were deemed potentially effective and secure. Patients’ and doctors’ discussions of the pros and cons of these 5 apps revealed that 3 out of the 5 are clearly more suitable, with the Cora Health app being judged most suitable overall.
Telerehabilitation’s Safety, Feasibility, and Exercise Uptake in Cancer Survivors: Process Evaluation
Authors: Dennett Amy , Harding Katherine E , Reimert Jacoba , Morris Rebecca , Parente Phillip , Taylor Nicholas F
Published: November 2021

Background

Access to exercise for cancer survivors is poor despite global recognition of its benefits. Telerehabilitation may overcome barriers to exercise for cancer survivors but is not routinely offered.

Objective

Following the rapid implementation of an exercise-based telerehabilitation program in response to COVID-19, a process evaluation was conducted to understand the impact on patients, staff, and the health service with the aim of informing future program development.

Methods

A mixed methods evaluation was completed for a telerehabilitation program for cancer survivors admitted between March and December 2020. Interviews were conducted with patients and staff involved in implementation. Routinely collected hospital data (adverse events, referrals, admissions, wait time, attendance, physical activity, and quality of life) were also assessed. Patients received an 8-week telerehabilitation intervention including one-on-one health coaching via telehealth, online group exercise and education, information portal, and home exercise prescription. Quantitative data were reported descriptively, and qualitative interview data were coded and mapped to the Proctor model for implementation research.

Results

The telerehabilitation program received 175 new referrals over 8 months. Of those eligible, 123 of 150 (82%) commenced the study. There were no major adverse events. Adherence to health coaching was high (674/843, 80% of scheduled sessions), but participation in online group exercise classes was low (n=36, 29%). Patients improved their self-reported physical activity levels by a median of 110 minutes per week (IQR 90-401) by program completion. Patients were satisfied with telerehabilitation, but clinicians reported a mixed experience of pride in rapid care delivery contrasting with loss of personal connections. The average health service cost per patient was Aus $1104 (US $790).

Conclusions

Telerehabilitation is safe, feasible, and improved outcomes for cancer survivors. Learnings from this study may inform the ongoing implementation of cancer telerehabilitation.
Long-Term Survival Among Histological Subtypes in Advanced Epithelial Ovarian Cancer: Population-Based Study Using the Surveillance, Epidemiology, and End Results Database (Preprint)
Authors: Yang Shi-Ping , Su Hui-Luan , Chen Xiu-Bei , Hua Li , Chen Jian-Xian , Hu Min , Lei Jian , Wu San-Gang , Zhou Juan
Published: November 2021

BACKGROUND

Actual long-term survival rates for advanced epithelial ovarian cancer (EOC) are rarely reported.

OBJECTIVE

This study aimed to assess the role of histological subtypes in predicting the prognosis among long-term survivors (≥5 years) of advanced EOC.

METHODS

We performed a retrospective analysis of data among patients with stage III-IV EOC diagnosed from 2000 to 2014 using the Surveillance, Epidemiology, and End Results cancer data of the United States. We used the chi-square test, Kaplan–Meier analysis, and multivariate Cox proportional hazards model for the analyses.

RESULTS

We included 8050 patients in this study, including 6929 (86.1%), 743 (9.2%), 237 (2.9%), and 141 (1.8%) patients with serous, endometrioid, clear cell, and mucinous tumors, respectively. With a median follow-up of 91 months, the most common cause of death was primary ovarian cancer (80.3%), followed by other cancers (8.1%), other causes of death (7.3%), cardiac-related death (3.2%), and nonmalignant pulmonary disease (3.2%). Patients with the serous subtype were more likely to die from primary ovarian cancer, and patients with the mucinous subtype were more likely to die from other cancers and cardiac-related disease. Multivariate Cox analysis showed that patients with endometrioid (hazard ratio [HR] 0.534, P<.001), mucinous (HR 0.454, P<.001), and clear cell (HR 0.563, P<.001) subtypes showed better ovarian cancer-specific survival than those with the serous subtype. Similar results were found regarding overall survival. However, ovarian cancer–specific survival and overall survival were comparable among those with endometrioid, clear cell, and mucinous tumors.

CONCLUSIONS

Ovarian cancer remains the primary cause of death in long-term ovarian cancer survivors. Moreover, the probability of death was significantly different among those with different histological subtypes. It is important for clinicians to individualize the surveillance program for long-term ovarian cancer survivors.
A NEW ROBUST ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF RIBOCICLIB AND LETROZOLE IN SOLID DOSAGE FORM (TABLET)
Authors: SATAPATHY BHAGYALATA , BANGARI CHAITANYA
Published: November 2021

Objective: The objective of the study was to develop a new robust, sensitive, precise, accurate RP-HPLC analytical method and validate for simultaneous estimation of ribociclib and letrozole in solid dosage form (tablet).
Methods: The chromatographic separation was carried out on Waters, symmetry C18 (150 mm×4.6 mm with 3.5 μm), mobile phase used was a mixture of buffer and acetonitrile in the ratio of 80:20, with flow rate of 1ml/min and injection volume of 10 μL for the assay. The detection was done using PDA at 260 nm, with run time of 5 min. The retention time for the drugs ribociclib and letrozole was detected to be 2.648 min and 3.151 min, respectively. The method was validated according to ICH guidelines.
Results: The linearity of letrozole and ribociclib was observed to be in the range of 0.50–7.50 and 40.01–600.15, Correlation coefficient (r2) 0.999 and 0.9983, respectively. Accuracy for ribociclib and letrozole is carried out by repeatable concentrations of 50%, 100%, and 150. Validation factors of robustness and ruggedness were detected to be in limits.
Conclusion: The developed method was simple, rapid, and consistent; it can be used for the simultaneous estimation of ribociclib and letrozole tablet dosage form in routine analysis.
STUDY ON ANTIMICROBIAL RESISTANCE PATTERN IN A TERTIARY CARE HOSPITAL – AN OBSERVATIONAL RETROSPECTIVE STUDY
Authors: M RANGAPRIYA , LORANCE ALINA , VARGHESE ANISHA MERIN , HANIF ARSHI , S ARUNA
Published: November 2021

Objective: The aim of the study was to monitor the magnitude and trends in antimicrobial resistance through surveillance programs and bacteriological diagnostic methods.
Methods: The study research has performed a retrospective observational study for period of 6 months (Dec 2019–June 2020) to determine the antimicrobial susceptibility pattern on cultures of various specimens at Vivekanandha Medical Care Hospital. The resultant data were computed in Microsoft Excel. Analyses were expressed as the total number, frequencies, and percentage.
Results: A total of 110 culture and sensitivity reports were collected from microbiology departments. Among the culture report, 84% accounted for gram-negative and 16% for Gram-positive organisms. Out of eight specimens, 15 different bacteria were identified and the most common bacteria were Klebsiella pneumonia (25%), E. coli (14%), Staphylococcus aureus (13%), and Pseudomonas aeruginosa (12%).
Conclusion: The interferences from the present study can help in bridging the gap in future educations, training, and adequate decision-making.
CONSUMPTION TREND OF OPIOIDS IN AMBULATORY PATIENTS IN ALBANIA 2014-2019
Authors: KAKARIQI LAERTA , XHAXHO SOKRAT , DEDA LEONARD , VYSHKA GENTIAN
Published: November 2021

Objective: The aim of this paper is to evaluate 6‐year trends in community use of prescribed opioid analgesics in Albania, using the Anatomic Therapeutic Chemical Classification-Defined Daily Dose methodology.
Methods: We collected the data from the database of the Health Insurance Institute (HII). Analysis of the data includes the period 2014–2019; also, we analyzed the data of import and domestic production of drugs, which represent the real consumption of drugs in the country. These data were subsequently involved in a comparative analysis of the utilization data according to the HII.
Results: We report a 2.5 fold increase in opioid utilization over the study period. The maximal rise in consumption refers to fentanyl, oxycodone, and tramadol. Meanwhile, the maximal values of consumption refer to strong opiate, morphine. We note that around 30% of the consumption of this class flows out of the scheme. Furthermore, around 25% of consumption of morphine and oxycodone flows out of scheme too. Meanwhile, the tramadol consumption runs out of the scheme over 200%.
Conclusions: The outcomes indicate that patients in Albania have low access to opioids medications mainly because of low opioids availability. A strong opiophobia among the population and the medical professionals constitutes one of the major impediments for efficient palliative care.
БОРТОВЫЕ РАДИОЛОКАЦИОННЫЕ ИНФОРМАЦИОННО-УПРАВЛЯЮЩИЕ СИСТЕМЫ: СОВРЕМЕННОЕ СОСТОЯНИЕ И НАПРАВЛЕНИЯ РАЗВИТИЯ
Authors: Антипов В.Н. , Колтышев Е.Е. , Медуницин Н.Б. , Сусляков Д.Ю. , Фролов А.Ю. , Янковский В.Т.
Published: November 2021

Рассмотрены состояние и направления развития аппаратуры и программноалгоритмического обеспечения современных бортовых радиолокационных информационно-управляющих систем.
ОЦЕНКА НАДЕЖНОСТИ СУБ-100-НМ КМОП ИС С ИСПОЛЬЗОВАНИЕМ УСКОРЕННЫХ ИСПЫТАНИЙ ТЕСТОВЫХ СТРУКТУР
Authors: Сивченко А.С.
Published: November 2021

Разработаны тестовые структуры, методики и автоматизированные программы ускоренных измерений, позволяющие проводить оценку надежности суб-100-нм КМОП ИС. Представлены результаты исследования основных механизмов физических отказов КМОП-технологии с проектными нормами 65 нм.
СИСТЕМА ПОМОЩИ ВОДИТЕЛЮ (ADAS) ОТ КОМПАНИИ АО "ПКК МИЛАНДР"
Authors: Мякочин Ю.О.
Published: November 2021

Представлены результаты разработки платформы для построения системы помощи водителю для дорожного транспорта. Система состоит из трех компонентов: миллиметрового радара, цифровой камеры и блока управления автомобилем.
Konsep diri membaca dan minat baca pada siswa sekolah dasar
Authors: Ama Roy Gustaf Tupen , Widyana Rahma
Published: November 2021

Reading interest is very important for students in the learning process. This study aimed to determine the correlations between reading self concept and students reading interest. In this study, the researcher used two scales namely scaleof reading self concept, and scale of students interest in reading. The population in this study were all students of grade3,4,5 at X Sleman Elementary School in Yogyakarta, Indonesia. The sampling technique in this study was incidentalsampling with a sample size of 124. The results of the analysis show that there is a correlation between reading self concept and students reading interest with an r value of 0.855 (p = 0.01). It is important for elementary school students to form a reading self concept so that a high reading self concept will increase students reading interest.
Enfermagem e a atenção à saúde da população indígena brasileira: Scoping review
Authors: Silva Berenice , Dalla Nora Carlise Rigon
Published: November 2021

Objetivo: O presente estudo objetiva descrever a produção do conhecimento da enfermagem sobre atenção à saúde da população indígena Brasileira. Método: Realizou-se uma scoping review nas bases LILACS, IBECS, MEDLINE, SCOPUS, SciELO, BDENF, BTDB, Portal de Periódicos da CAPES e google acadêmico, em janeiro e fevereiro de 2020. Incluíram-se artigos originais, teses e dissertações. A revisão abrangeu 16 estudos publicados entre 2010 e 2018. Resultados: Da análise, resultaram duas categorias: as ações de enfermagem no cuidado a população indígena Brasileira e as modalidades assistenciais que são utilizadas pela enfermagem no cuidado a população indígena. Conclusão: Conclui-se que os resultados desta revisão podem ser úteis para os enfermeiros que atuam no cuidado a população indígena, os quais precisam estar preparados e sensibilizados para os desafios que incluem trabalhar com essa população.
Significado de la experiencia materna en torno al apoyo durante su proceso de amamantamiento
Authors: Carrasco Salazar Paulina , Márquez-Doren Francisca , Lucchini-Raies Camila
Published: November 2021

Introducción: Se ha descrito la existencia de experiencias de la vida de las personas que tienen la capacidad de modular el sistema nervioso, lo que influye directamente en el desarrollo humano. Intervenir oportunamente en la primera infancia tiene el potencial de impactar positivamente en su desarrollo. En esta lógica, la lactancia materna cobra especial protagonismo, ya que aumenta la probabilidad de sobrevivir, brinda una nutrición y estimulación adecuada, favorece un entorno seguro, además de ser un inmenso aporte en el fortalecimiento de los lazos sociales, entre otros beneficios. El apoyo que reciba la madre durante el proceso es fundamental para lograr un amamantamiento exitoso. Objetivo: Develar el significado de la experiencia materna en torno al apoyo en el proceso de amamantamiento. Metodología: Estudio de diseño fenomenológico en el cual se realizó un análisis con datos secundarios, según la perspectiva de Edmund Husserl. Para asegurar el rigor metodológico de esta investigación se aplicaron los criterios de Guba y Lincoln. Los aspectos éticos de la investigación fueron abordados desde los siete requisitos éticos de Ezekiel Emanuel. Resultados: El significado de la experiencia materna en torno al apoyo en el proceso de amamantamiento se develó en cuatro categorías comprensivas: la experiencia materna de amamantamiento, experiencia de apoyo de los profesionales de la salud, experiencia de apoyo de la pareja y experiencia de apoyo de otros familiares. Conclusión: Las tres fuentes de apoyo identificadas nutren y modulan la experiencia de amamantamiento de manera complementaria, por lo que la indivisibilidad de las influencias ejercidas por ellas es una característica constitutiva para que el apoyo sea percibido por las madres como comprensivo y contenedor.
The Changes in an Childhood Teacher While Caring for Animals and Plants Based on the Viewpoint of Sustainable Development
Authors: Park Su Kyoung , Lee Yeon Ho
Published: November 2021

Park Su Kyoung);이연호(Lee Yeon Ho
Scqubits: a Python package for superconducting qubits
Authors: Groszkowski Peter , Koch Jens
Published: November 2021

scqubits is an open-source Python package for simulating and analyzing superconducting circuits. It provides convenient routines to obtain energy spectra of common superconducting qubits, such as the transmon, fluxonium, flux, cos(2ϕ) and the 0-π qubit. scqubits also features a number of options for visualizing the computed spectral data, including plots of energy levels as a function of external parameters, display of matrix elements of various operators as well as means to easily plot qubit wavefunctions. Many of these tools are not limited to single qubits, but extend to composite Hilbert spaces consisting of coupled superconducting qubits and harmonic (or weakly anharmonic) modes. The library provides an extensive suite of methods for estimating qubit coherence times due to a variety of commonly considered noise channels. While all functionality of scqubits can be accessed programatically, the package also implements GUI-like widgets that, with a few clicks can help users both create relevant Python objects, as well as explore their properties through various plots. When applicable, the library harnesses the computing power of multiple cores via multiprocessing. scqubits further exposes a direct interface to the Quantum Toolbox in Python (QuTiP) package, allowing the user to efficiently leverage QuTiP's proven capabilities for simulating time evolution.
Linguistic formulas - a priority of modern teaching "In the universe of grammar I"
Authors:   The University of Georgia, Tbilisi, Georgia, Shavtvaladze Nana
Published: November 2021

We have the variety of forms, ways, methods, strategies of teaching in the 21st century. It`s important to achieve the goal, to gain the result, to perceive the given materials. Everyone is free to choose any ways from the given approaches. Most of the textbooks are dedicated to English language. English is dominated worldwide and it`s not only foreign language but a second language as well in many countries. There are different visions and approaches in teaching a language as a foreign or as a second one. Textbooks are mades based on the four skills: reading, writing, speaking, listening. Demand of Georgian as a foreign language has increased. Many philologists have occupied themselves with teaching Georgian as a Foreign language. Plus, they have means of teaching, once there are many textbooks already created, especially for the beginner levels. Online teaching has also increased these demands. Every author forms his/her own style, approach and vision when creating a textbook. In my opinion, it`s important to first calculate the common methodical view from the beginning to the end and only then start working on the new textbook. This kind of approach helps instructor gain the results and consistent logical motion is encouraging hopeful for the student.
On strong convergence theorems for a viscosity-type extragradient method
Authors: Ceng L.C. , Fong C.S.
Published: November 2021

In this paper, we introduce a general viscosity-type extragradient method
for solving the fixed point problem of an asymptotically nonexpansive
mapping and the variational inclusion problem with two accretive operators.
We obtain a strong convergence theorem in the setting of Banach spaces. In
terms of this theorem, we establish the strong convergence result for
solving the fixed point problem (FPP) of an asymptotically nonexpansive
mapping and the variational inequality problem (VIP) for an inverse-strongly
monotone mapping in the framework of Hilbert spaces. Finally, this result is
applied to deal with the VIP and FPP in an illustrating example.
Quasicontinuous functions and the topology of uniform convergence on compacta
Authors: Holá Lubica , Holý Dusan
Published: November 2021

Let X be a Hausdorff topological space, Q(X,R) be the space of all
quasicontinuous functions on X with values in R and ?UC be the topology of
uniform convergence on compacta. If X is hemicompact, then (Q(X,R), ?UC) is
metrizable and thus many cardinal invariants, including weight, density and
cellularity coincide on (Q(X,R), ?UC). We find further conditions on X under
which these cardinal invariants coincide on (Q(X,R), ?UC) as well as
characterizations of some cardinal invariants of (Q(X,R), ?UC). It is known
that the weight of continuous functions (C(R,R), ?UC) is ?0. We will show
that the weight of (Q(R,R), ?UC) is 2c.
Association between bipolar affective disorder, use of antidepressants and osteoporosis
Authors: Cvjetkovic-Bosnjak Mina , Okanovic Milana , Pavlovic Sanja , Zivanovic Olga , Vasic Vesna , Vejnovic Ana-Marija
Published: November 2021

Introduction/Objective. Osteoporosis is one of the most common comorbid disorders in depressive mood disorder. The aim of this study was to assess the association between the use of antidepressants and osteoporosis in patients with bipolar affective disorder (BPAD). Methods. The study included 73 inpatients, aged 50?72 years, male and female, hospitalized with a depressive episode of BPAD from 2016 to 2020 at the Clinic of Psychiatry, Clinical Centre of Vojvodina, divided into two groups: a) the first group (40) was treated with selective serotonin reuptake inhibitors (SSRIs) in combination with mood stabilizer (lithium carbonate/lamotrigine); b) the second group (33) was treated with mood stabilizer only. Study included two control groups as well. Clinical measurements of bone mineral density at lumbar spine and hip was made using dual energy X-ray absorptiometry. CrossLaps and levels of calcium and vitamin D were collected from blood samples. The data was analyzed by the analysis of variance and the Kruskal?Wallis test. Results. Osteoporosis was registered in 25% of patients in the first group and in 18% of patients in the second group, while osteopenia was observed within 40% of patients in the first group and in 37% of patients in the second group. There was significant difference in value of CrossLaps, and the level of 25(OH)D vitamin between the control groups and the first two groups, as well as in prevalence of osteoporosis and osteopenia. Conclusion. Depressive episodes in BPAD is connected with higher prevalence of osteoporosis. Patients treated with SSRIs have higher prevalence of osteoporosis than patients treated with mood stabilizers only.
Ancestry-Matched and Cross-Ancestry Genetic Risk Scores of Type 2 Diabetes in Pregnant Women and Fetal Growth—A Study in an Ancestrally Diverse Cohort
Authors: Ouidir Marion , Zeng Xuehuo , Chatterjee Suvo , Zhang Cuilin , Tekola-Ayele Fasil
Published: November 2021

Maternal genetic
variants associated with offspring birth weight and adult type 2 diabetes (T2D)
risk loci show some overlap. Whether T2D genetic risk influences longitudinal
fetal weight and the gestational timing when these relationships begin is
unknown. We investigated the associations of T2D genetic risk score (GRS) with
longitudinal fetal weight and birth weight among 1,513 pregnant women from four
ancestral groups. Women had up to 5 ultrasonography. Ancestry-matched GRS were
constructed separately using 380 European- (GRSeur), 104 African- (GRSafr),
and 189 East Asian- (GRSeas) related T2D loci discovered in different
population groups. Among European Americans, the highest quartile GRSeur
was significantly associated with 53.8 g higher fetal weight (95% confidence
interval [CI] 19.2-88.5 g) over the pregnancy. The associations began at
gestational week 24 and continued through week 40, with a 106.8 g (95% CI:
6.5-207.1 g) increase in birth weight. The findings were similar in analysis further
adjusted for maternal glucose challenge test results. No consistent association
was found using ancestry-matched or cross-ancestry GRS in non-Europeans. In
conclusion, T2D genetic susceptibility may influence fetal growth starting at mid-second
trimester among Europeans. Absence of similar associations in non-Europeans urges
the need for further genetic T2D studies in diverse ancestries.
The Effect of General Adiposity and Central Body Fat Distribution on the Circulating Metabolome: a Multi-Cohort Non-Targeted Metabolomics Observational and Mendelian Randomization Study
Authors: Ahmad Shafqat , Hammar Ulf , Kennedy Beatrice , Salihovic Samira , Ganna Andrea , Lind Lars , Sundström Johan , Ärnlöv Johan , Berne Christian , Risérus Ulf , Magnusson Patrik KE , Larsson Susanna C , Fall Tove
Published: November 2021

Obesity is associated with adverse health outcomes, but the metabolic
effects have not yet been fully elucidated. We aimed to investigate the
association between adiposity with circulating metabolites and to address
causality with Mendelian randomization (MR). Metabolomics data was
generated by non-targeted ultra-performance liquid-chromatography coupled to time-of-flight
mass-spectrometry in plasma and serum from three population-based Swedish cohorts:
ULSAM (N=1,135), PIVUS (N=970), and TwinGene (N=2,059). We assessed
associations between general adiposity measured as body mass index (BMI) and central
body fat distribution measured as waist-to-hip ratio adjusted for BMI (WHRadjBMI)
with 210 annotated metabolites. We employed MR analysis to assess causal effects.
Lastly, we attempted to replicate
the MR findings in the KORA and TwinsUK cohorts (N=7,373), the CHARGE
consortium (N=8,631), the Framingham Heart Study (N=2,076) and the DIRECT consortium
(N=3,029). BMI
was associated with 77 metabolites, while WHRadjBMI was associated with 11 and
3 metabolites in women and men, respectively. The MR analyses in the Swedish
cohorts suggested a causal association (p-value
<0.05) of increased general adiposity and reduced levels of arachidonic
acid, dodecanedioic acid and lysophosphatidylcholine (P-16:0) as well as with increased creatine levels. The replication
effort provided support for a causal association of adiposity on reduced levels
of arachidonic acid (p-value 0.03). Adiposity
is associated with variation of large parts of the circulating metabolome,
however causality needs further investigation in well-powered cohorts.
Syndromic Monogenic Diabetes Genes Should be Tested in Patients With a Clinical Suspicion of MODY
Authors: Colclough Kevin , Ellard Sian , Hattersley Andrew , Patel Kashyap
Published: November 2021

At present, outside of
infancy, genetic testing for monogenic diabetes is typically for mutations in MODY
genes that predominantly result in isolated diabetes. Monogenic diabetes syndromes
are usually only tested when this is supported by specific syndromic clinical
features. It is not known how frequently patients with suspected MODY have a
mutation in a monogenic syndromic diabetes gene and thus missed by present
testing regimes.

We performed
genetic testing of 27 monogenic diabetes genes (including 18 associated
with syndromic diabetes) for 1280 patients with a clinical suspicion of MODY
from routine clinical care that were not suspected of having monogenic syndromic
diabetes. We confirmed monogenic diabetes in 297 (23%) patients. Mutations in 7
different syndromic diabetes genes accounted for 19% (95%CI 15-24%) of all monogenic diabetes. The
mitochondrial m.3243A>G and mutations in HNF1B were responsible for
the majority of mutations in syndromic diabetes genes. They were also the 4th
and 5th most common causes of monogenic diabetes overall. These patients lacked typical features and their
diabetes phenotypes overlapped with non-syndromic monogenic diabetes patients. Syndromic
monogenic diabetes genes (particularly m.3243A>G and HNF1B) should be routinely tested in patients with suspected MODY that
do not have typical features of a genetic syndrome.
Numerical Modelling of Multiphase Flow With Application to Industrial Processes
Authors:   , Bhokare Ashutosh
Published: November 2021

Multiphase ﬂows are witnessed often in nature and the industry. Simulating the behaviour of multiphase ﬂows is of importance to scientists and engineers for better prediction of phenomena and design of products. This thesis aims to develop a multiphase ﬂow framework which can be applied to industrial applications such as placement of concrete in construction and proppant transport in oil and gas. Techniques available in literature to model multiphase ﬂows are systematically introduced and each of their merits and demerits are analysed. Their suitability for diﬀerent applications and scenarios are established. The challenges surrounding the placement of fresh concrete in formwork is investigated. Construction defects, the physics behind these defects and existing tests used to monitor fresh concrete quality are evaluated. Methods used to simulate fresh concrete ﬂow as an alternative to experiments are critically analysed. The potential beneﬁts of using numerical modelling and the shortcoming of the existing approaches are established. It is found that the homogeneous Bingham model is currently the most widely used technique to model fresh concrete ﬂow. Determining the Bingham parameters for a given concrete mix remains a challenge and a novel method to obtain values for them is demonstrated in this work. The Bingham model is also applied to a full-scale tremie concrete placement procedure in a pile. Knowledge on the ﬂow pattern followed by concrete being placed using a tremie is extracted. This is used to answer questions which the industry currently demands. The need for a more sophisticated model is emphasised in order to obtain an even greater understanding of fresh concrete ﬂow behaviour. A CFD-DEM framework in which the multiphase nature of concrete is captured is developed. To validate this framework a new benchmark test is proposed in conjunction with the ﬂuidised bed experiment. A comparative study of the drag models used in CFD-DEM approaches is performed to systematically assess each of their performances. CFD-DEM modelling is then applied to model fresh concrete ﬂow and its potential to model defect causing phenomena is demonstrated. A model to capture more complex behaviours of concrete such as thixotropy is introduced and demonstrated.
Assessment of sustainability of the Lviv city transport system according to the indicator of accessibility
Authors:   Lviv Polytechnic National University, Zhuk Mykola , Pivtorak Halyna ,   Lviv Polytechnic National University, Gits Ivanna ,   Lviv Polytechnic National University
Published: November 2021

Transport accessibility of the territory determines the possibility of getting a certain area using a certain transport mode of the existing transport network. The paper describes the concept of accessibility of the territory as a factor of sustainability of the urban transport system and methods of its assessment for urban conditions. It is proposed to use the indicator of the number of non-stop public transport routes between transport zones as a criterion for the "cost" of travel. Non-stop travel increases the comfort of public transport and reduces the financial costs of the passenger. The route network of the city of Lviv and interconnections of transport zones by public transport routes (bus, tram, and trolleybus) are analyzed. Modelling of passenger traffic volumes and their distribution by modes (private transport, public transport, and pedestrian traffic) was done in the PTV Visum software based on the matrix of a duration of movement and the matrix of the number of non-stop routes. It was found that at commensurate distances between transport zones, the number of non-stop routes increases the share of public transport users. The relationship between the number of non-stop routes and the share of public transport users is described by the logarithmic dependence. Comparing the simulated passenger flows on the public transport routes with the results of field researches, it was found that taking into account the number of non-stop routes between transport zones during the simulation allows increasing the accuracy of the results. Further research may focus on analyzing the impact of other factors that characterize the accessibility of the territory on the distribution of transport users between modes, and on the development of recommendations to the responsible city authorities to improve the city's passenger route network.
Minimization of traffic delay in traffic flows with coordinated control
Authors:   Lviv Polytechnic National University, Royko Yuriy , Yevchuk Yurii ,   Lviv Polytechnic National University, Bura Romana ,   Lviv Polytechnic National University
Published: November 2021

The method and results of transport research, carried out by field research method, on the determination of the main indicators of traffic flows with significant unevenness of the movement on the arterial street in conditions of coordinated control is reviewed in the paper. Time parameters of traffic light control for which a reduction in traffic delay is achieved in direct and opposite traffic flow by the change of permissive signal depending on traffic intensity are determined using the simulation method. Change (increase) of the duration of the permissive signal provides uninterrupted movement of vehicles` group during their passage of stop-line at traffic light objects. The proposed method can be used on sections of transport networks with coordinated control, where there is significant heterogeneity of traffic flow, and it prevents the dissipation of groups that consist of vehicles with different dynamic characteristics. Such a result is being performed in the case when in the system of automated control, which combines adjacent intersections on an arterial street, fixed-time program control of traffic light signalization is operating. In this condition, there is a possibility to adjust the duration of signals of traffic light groups by correcting the width (permissive signal duration) and angle of inclination (speed of movement) of the timeline in coordination graphs. The scientific novelty of this research is that the method of traffic delay minimization in conditions of coordinated control acquired further development. The essence of the method is in the controlled change of the range of permissive signal duration in conditions of simultaneous control of the speed of movement between adjacent intersections. Practical value is the application of different programs of traffic light control on sections of arterial streets in transport districts where a significant difference of values of traffic intensity by directions is in morning and evening peak periods.
Intervention Proposal for Infant Prognathism: A Case Report in a Non-Syndromic Pediatric Patient
Authors: Chedid Silvia J. , Húngaro Renata
Published: November 2021

Treating Class III malocclusions has been presently considered one of the most challenging and complex interventions of orthodontic daily practice. In this study, we report a case of a 17-month-old female patient, initially diagnosed with Angle Class III malocclusion, mandibular protrusion, and without genetic syndromes. Upon initial admission at the dental office, patient’s parents reported an inadequate bite pattern while the patient tried to eat solid food. Upon dental examination, a negative overjet of 8 millimeters was noticed and a two-phased treatment plan was established: 1. Performance of functional exercises; 2. Implementation of protractor device associated with masticatory guidance exercises. Radiographic examination and cephalometric analyses were performed throughout the case follow-up. Overall, the digital compression protocol carried out reverted the primary mandibular protrusion of -8 millimeters to +1 millimeters overbite, during the 6 months of treatment. In addition, the use of premaxillary protractor appliance increased the overbite to + 2 millimeters. The patient responded satisfactory to the treatment plan performed, and after 2 years, a proper primary occlusion, oral functionality, and facial aesthetics were improved.
POLA PERTUMBUHAN DAN PRODUKSI TANAMAN CABAI MERAH KERITING (Capsicum annuum L.) AKIBAT APLIKASI KALIUM NITRAT PADA DAERAH DATARAN RENDAH
Authors: Handono Satrio Tri , Hendarto Kus , Kamal Muhammad
Published: November 2021

Cabai (Capsicum annuum L.) merupakan salah satu komoditas hortikultura yang memiliki nilai ekonomi penting di Indonesia, sehingga budidaya cabai sangat menarik bagi petani.  Permintaan produk cabai cenderung meningkat terus sehingga dapat diandalkan sebagai komoditas nonmigas. Seiring dengan permintaan yang meningkat sehingga kurangnya pasokan yang tersedia maka peningkatan luas tanam diarahkan untuk mencapai keseimbangan pasokan dan permintaan. Salah satu usaha yang dapat dilakukan adalah melakukan teknik budidaya yang baik dan benar sehingga hasil yang diperoleh optimal. Salah satu aspek yang penting dalam budidaya tanaman adalah pemupukan.Penelitian ini bertujuan untuk mengetahui respon pola pertumbuhan tanaman cabai merah terhadap aplikasi Kalium Nitrat dan untuk mengetahui respon komponen hasil cabai terhadap pemberian Kalium Nitrat dengan konsentrasi berbeda. Penelitian ini dilaksanakan di Desa Sukabanjar Kecamatan Gedong Tataan Kabupaten Pesawaran dari Oktober 2011 sampai April 2012. Penelitian disusun menggunakan Rancangan acak kelompok dengan  perlakuan tunggal yaitu konsentrasi KNO3 yang terdiri atas : 0, 2, 4, 6, 8 g l-1, dengan 3 kali ulangan.  Seluruh data yang diperoleh dianalisis ragam. Homogenitas  ragam diuji dengan uji Bartlett sedangkan aditivitas diuji dengan uji Tukey. Analisis data dilanjutkan dengan uji polinomial ortogonal pada taraf 5%. Hasil penelitian menunjukan bahwa pada pola pertumbuhan vegetatif untuk variabel tinggi tanaman dan tingkat percabangan aplikasi kalium nitrat pada berbagai taraf konsentrasi yaitu : 0, 2, 4, 6, 8 g l-1 tidak memberikan pengaruh yang nyata dan pada pemberian kalium nitrat dengan konsentrasi 4, 6, 8 g l-1 meningkatkan jumlah bunga di tanaman cabai. Peningkatan  jumlah buah tertinggi terdapat pada aplikasi kalium nitrat dengan konsentrasi 8 g l-1, sedangkan pada bobot buah total tertinggi terjadi pada konsentrasi  6 g l-1.
RESPONS GULMA TERHADAP LAMA FERMENTASI CAIRAN PULP KAKAO SEBAGAI BIOHERBISIDA
Authors: Kusnendar Dwi Apri , Sembodo Dad R.J. , Susanto Herry
Published: November 2021

Cairan fermentasi pulp kakao merupakan limbah yang belum banyak dimanfaatkan. Kandungan asam organik yang terdapat pada cairan fermentasi membuat limbah tersebut berpotensi sebagai bioherbisida pascatumbuh. Berdasarkan hasil uji awal limbah ini dapat meracuni dengan munculnya klorosis pada gulma.  Penelitian bertujuan untuk mengetahui: (1) pengaruh lama fermentasi cairan buah kakao terhadap tingkat keracunan pada gulma; (2) pengaruh beberapa jenis gulma terhadap tingkat keracunan; dan (3) pengaruh interaksi antara lama fermentasi dan jenis gulma terhadap tingkat keracunan gulma. Aplikasi pulp kakao dilakukan secara pascatumbuh, perlakuan disusun secara faktorial (10 x 7).  Faktor pertama adalah lama fermentasi pulp kakao (F) yaitu 0, 1, 2, 3, 4, 5, 6, 7, 8 minggu dan kontrol (tanpa diaplikasi)) sebagai pembanding. Faktor kedua adalah 7 jenis gulma (G) yaitu Mimosa invisa; Borreria latifolia; Richardia brasiliensis; Asystasia gangetica; Setaria plicata; Axonopus compressus; Cyperus kyllingia.  Percobaan dilakukan dengan Rancangan Petak Berjalur (Strip Plot Design). Data dianalisis ragam dan dilanjutkan dengan uji BNT pada α 0,05. Hasil penelitian menunjukkan bahwa: (1) Carian pulp kakao yang difermentasi selama 4 sampai 5 minggu dapat meracuni gulma paling tinggi. (2) Cairan fermentasi pulp kakao yang diaplikasikan secara langsung ke gulma sangat efektif dalam meracuni gulma M. pudica, B. latifolia, R. brasiliencis, A. gangetica, dan A. compressus, sedangkan Setaria plicata dan Cyperus kyllingia tahan terhadap aplikasi cairan pulp kakao yang di fermentasi; (3) Ada pengaruh interaksi antara lama fermentasi dan jenis gulma dalam mempengaruhi persentase keracunan.