bluuebunny/crossref_metadata_2025 huggingface dataset:
Integrating Electronic Medical Records and Claims Data for Influenza Vaccine Research
Authors: Boikos Constantina , Imran Mahrukh , De Lusignan Simon , Ortiz Justin R. , Patriarca Peter A. , Mansi James A.
Published: May 2022

Real-world evidence (RWE) increasingly informs public health and healthcare decisions worldwide. A large database has been created (“Integrated Dataset”) that integrates primary care electronic medical records with pharmacy and medical claims data on >123 million US patients since 2014. This article describes the components of the Integrated Dataset and evaluates its representativeness to the US population and its potential use in evaluating influenza vaccine effectiveness. Representativeness to the US population (2014–2019) was evaluated by comparison with demographic information from the 2019 US census and the National Ambulatory Medical Care Survey (NAMCS). Variables included in the Integrated Dataset were evaluated against World Health Organization (WHO) defined key and non-critical variables for evaluating influenza vaccine performance. The Integrated Dataset contains a variety of information, including demographic data, patient medical history, diagnoses, immunizations, and prescriptions. Distributions of most age categories and sex were comparable with the US Census and NAMCS populations. The Integrated Dataset was less diverse by race and ethnicity. Additionally, WHO key and non-critical variables for the estimation of influenza vaccine effectiveness are available in the Integrated Dataset. In summary, the Integrated Dataset is generally representative of the US population and contains key variables for the assessment of influenza vaccine effectiveness.
Immunity after HPV Vaccination in Patients after Sexual Initiation
Authors: Pruski Dominik , Łagiedo-Żelazowska Małgorzata , Millert-Kalińska Sonja , Sikora Jan , Jach Robert , Przybylski Marcin
Published: May 2022

Vaccinations against human papillomavirus (HPV) are included in the primary prevention of precancerous intraepithelial lesions and HPV-related cancers. Despite the undeniable effectiveness of vaccination in the juvenile population, there is still little research on the effect in patients after sexual initiation. Our study aims to assess anti-HPV (L1 HPV) antibodies in healthy patients and diagnosed cervical pathology after 9-valent vaccination. We provide a prospective, ongoing 12-month, non-randomised pilot study in which 89 subjects were enrolled. We used an enzyme-linked immunosorbent assay to determine IgG class antibodies to HPV. We noted significantly higher levels of antibodies in vaccinated individuals than in the unvaccinated control group. The above work shows that vaccination against HPV might be beneficial in patients after sexual initiation as well as in those already diagnosed with HPV or SIL infection.
ProAKAP4 Semen Concentrations as a Valuable Marker Protein of Post-Thawed Semen Quality and Bull Fertility: A Retrospective Study
Authors: Dordas-Perpinyà Marta , Sergeant Nicolas , Ruelle Isabelle , Bruyas Jean-François , Charreaux Frédéric , Michaud Sandrine , Carracedo Sara , Catalán Jaime , Miró Jordi , Delehedde Maryse , Briand-Amirat Lamia
Published: May 2022

Functional sperm quality markers to predict bull fertility have been actively investigated. Among them, proAKAP4, which is the precursor of AKAP4, the main structural protein in the fibrous sheath of spermatozoa; appears to be promising, especially since spermatozoa lacking AKAP4 expression were shown to be immotile, abnormal, and infertile. In this study, the objective was to evaluate proAKAP4 concentration values with the classic sperm motility descriptors and fertility outcomes (NRR at 90 days) in post-thawed conditions of 10 bulls’ semen. ProAKAP4 expression was confirmed by Western blotting and proAKAP4 concentrations were determined by ELISA. Variations in proAKAP4 concentrations were observed independently of the motility sperm descriptors measured using computer-assisted semen analysis (CASA). A ProAKAP4 concentration of 38.67 ± 8.55 ng/10 million spermatozoa was obtained as a statistical mean of all samples. Threshold values of proAKAP4 were then determined between 19.96 to 96.95 ng/10 million spermatozoa. ProAKAP4 concentrations were positively correlated with progressive motility and the linearity coefficient. The sperm showing the lowest progressive motility were the samples exhibiting proAKAP4 concentrations below 20 ng/10 million spermatozoa. Furthermore, proAKAP4 concentrations were significantly higher in bulls with a higher NRR in the field. Our results demonstrate a correlation between the semen concentration of proAKAP4 and NRR-90d (p = 0.05) in post-thawed bull semen, highlighting the potential of proAKAP4 as a predictive marker of bull fertility.
Forme della poesia
Authors: Driussi Paolo
Published: May 2022

L'analisi del testo è un campo di ricerca ampio e ricco. L'analisi linguistica formale dei testi non è diffusa, non certo in Italia, ma può aiutare proficuamente nella lettura e nell'interpretazione. Questo può essere facilmente dimostrato con la poesia. In questo articolo introduco alcuni fondamenti di questo approccio e mostro come si applicano a due poesie per presentare alcuni dei suoi vantaggi.
OPTIMIZACIÓN FINANCIERA PARA ESTABLECER UN SISTEMA AGROFORESTAL: COSTO-BENEFICIO, PRECIOS ALEATORIOS, DISTINTOS ESCENARIOS Y EXTERNALIDADES
Authors: Zamudio-Sánchez Francisco José , Romo-Lozano José Luis , Loera-García Guillermo
Published: May 2022

Se propone un sistema agroforestal en el noreste del estado de Morelos, México, como una alternativa para el uso sostenido de los recursos naturales. Los criterios de evaluación de la eficiencia del sistema fueron el aumento o constancia de la productividad de la tierra sin causar degradación, la optimización de la utilidad neta obtenida cuando hay restricciones de tierra-capital y una condición de riesgo medida por la relación beneficio-costo. Los costos de las externalidades se incorporaron como una alternativa para garantizar el restablecimiento de las condiciones originales del proceso de producción. Los precios de los productos se seleccionaron aleatoriamente de una distribución apropiada. La optimización del sistema se realizó en tres escenarios de rendimiento: desfavorable, promedio y favorable. Los resultados muestran que los cultivos extensivos de higo (Ficus carica L.) y chapulixtle (Dodonaea viscosa (L.) Jacq.) reducen los riesgos de la inversión con relación a los intensivos: calabacita (Cucurbita pepo (L.) Sesse y Moc), melón (Cucumis melo L.) y cebolla (Allium cepa L.). La tierra y el capital no fueron recursos comparables, cuando existe exceso o equilibrio de tierra frente a capital se obtienen soluciones racionales, no así cuando se tiene exceso de capital respecto al de tierra.
MEJOR PREDICTOR LINEAL E INSESGADO PARA APTITUD COMBINATORIA ESPECÍFICA DE LOS DISEÑOS DOS Y CUATRO DE GRIFFING
Authors: Montesinos-López Osval Antonio , Martínez-Garza Ángel , Mastache-Lagunas Ángel Agustín| , Rendón-Sánchez Gilberto
Published: May 2022

La estimación de parámetros en los experimentos de cruzas dialélicas ayuda a tomar decisiones objetivas en los programas de mejoramiento genético. En estos experimentos la estimación de aptitud combinatoria específica se ha efectuado como si el modelo fuera de efectos fijos, cuando se sabe que su naturaleza es aleatoria. Por ello en el presente trabajo, para los diseños dos y cuatro de Griffing establecidos en un diseño experimental de bloques completos al azar, se derivan los mejores predictores lineales e insesgados de aptitud combinatoria específica, bajo el modelo de efectos mixtos. Además, se presenta un algoritmo computacional en SAS-IML para la obtención de estos estimadores.
Does a Memorable Experience Exist During the Covid-19 Pandemic? a Natural Attraction Study
Authors: Andrianto Tomy , Septyandi Chandra Budhi , Hukma Shabiyya Agustin
Published: May 2022

During Pandemic Covid-19 natural attractions have become one of the favorite place to visit even though there are various restrictions on movement and activities. Most of the visitors try to explore unforgettable visiting experience during their visit. The aim of this research is to understand whether the visitors able to access a memorable experience during the Covid-19 pandemic at natural tourist attractions. This research aplied quantitative methods by using descriptive analysis from online survey of 100 respondents who visited Situ Pattengang as one of natural attraction from May to July 2021. As a result, visitors still able to access several memorable experiences but lacking several others. The highest dimension turns out to be refreshment out of daily activities, then hedonism experience and uniqueness in novelty. Then followed by interaction with local communities. While the third lowest dimension is involvement with activities, meaningfulness, and knowledges.
Seam pucker detection through presser foot displacement monitoring
Authors: GORAN DEMBOSKI , MAJA JANKOSKA , CARVALHO MIGUEL ANGELO
Published: May 2022

The paper investigates the relation between seam pucker, woven fabric formability, and the presser foot displacement
during stitch formation. Superimposed seams of class 1 were sewn in warp and weft direction using woven fabrics for
tailored garments. The presser foot height was continuously monitored during stitch formation for different sewing
machine speeds. The foot displacement during the sewing cycle was correlated with seam pucker. The obtained results
showed various patterns of pressure foot displacement regarding the sewing machine speeds. It was found that at a
lower machine speed there is no bouncing of the presser foot and the ratio of the height of the presser foot before and
after rising and declining movement versus double thickness of the fabric (h/T1), correlates significantly with the seam
pucker percentage. The fabrics having a higher h/T1 ratio showed a higher percentage of seam pucker. The obtained
results suggest that online monitoring of this parameter can be a useful indication of on-seam pucker appearance,
providing reliable means to obtain a quality seam.
Competitiveness indicators assessment of the textile organizations
from Serbia
Authors: MILETIĆ VUK S. , ĆURČIĆ NIKOLA V. , GRUJIĆ BILJANA VUČKOVSKI
Published: May 2022

An assessment of the indicators contributing to the success of the textile organizations doing business in Serbia from
the point of view of their specificities in relation to the other industrial sectors is the subject matter of the research study
presented in this paper. The original premise says that there are numerous factors that determine the competitiveness
of textile organizations, all those factors have a different influence on the results of those organizations’ business
activities. The study is aimed at singling out and assessing the factors significant for the adaptation of the existing
concept of the business operations undertaken by Serbian textile organizations through continuous changes in the
textile and clothes global market. Namely, once the Textile Agreement made between the member states of the World
Trade Organization ceased to be in force, trading textile products between the member states became completely
liberalized, which led to the competition within the world frameworks becoming much more severe. In order to respond
to said changes, there is a need for textile organizations to engage qualified personnel with competencies, knowledge
and skills (know-how), who is simultaneously able to respond to all the challenges they are faced within the conditions
of accelerated changes in the numerous indicators that determine their competitiveness. The obtained results are
indicative of the fact that the following are the key factors for their business success: design functions through the
continuous improvement of employees’ knowledge, investment in relationship marketing and the development of
domestic brands, together with the procurement of modern technological solutions and equipment. In the subject-matter
research study, the following methods were used, namely: hypothetical-deductive, analytical-deductive and
comparative, historical and statistical-descriptive, as well as comparative statistics methods (chi2-test, ANOVA).
Estrategias de utilización de un simulador de entrevistas de trabajo para adultos hipoacúsicos con ayudas auditivas
Authors:   , Quintana Nelba Graciela
Published: May 2022

La presente tesis desarrolla un prototipo de simulador en línea como herramienta de formación inclusiva para adultos postlocutivos. Es una propuesta de formación para un grupo de personas con discapacidad (PCD) emergente gracias a los avances de la tecnología - implantes cocleares y los audífonos de alta gama, sistemas de FM y demás dispositivos tecnológicos en constante desarrollo - que han permitido a muchas personas hipoacúsicas moderadas y severas poder seguir oyendo y aspirar a una mayor inclusión social, laboral y educativa.
Variedades del español de la Argentina: La alternancia de los verbos Perfecto Simple y Perfecto Compuesto
Authors:   , Álvarez Garriga Dolores
Published: May 2022

Uno de los principales interrogantes que se plantea esta investigación gira en torno a cuál es la esencia que define a los verbos y qué función cumplen en la comunicación. Este trabajo se centra específicamente en los significados de las formas verbales conocidas como Pretérito Perfecto Simple y Pretérito Perfecto Compuesto y se apoya en los principios teóricos fundamentales de la Escuela Lingüística de Columbia (Diver 1975, 1995) y de la Etnopragmática en particular (García 1988, 1995, Martínez 2009, 2012, 2020, Martínez y Speranza 2009, 2012). De acuerdo con esta mirada, se piensa que las estructuras lingüísticas tienen un significado único y que su aporte a la comunicación es constante e invariable. La teoría diveriana explica que la racional que asocia un significado con distintas explotaciones discursivas está posibilitada por la inteligencia humana, capaz de crear una infinita cantidad de mensajes con un número limitado de significados. Nuestro corpus de análisis es un corpus genuino de entrevistas orales a distintas comunidades de habla de la Argentina (rioplatense, sanjuanina y boliviana de Buenos Aires), desde donde parten las hipótesis de los significados y desde donde se testean, tanto cualitativa como cuantitativamente, la validez de dichas hipótesis. El hecho de que las fuentes correspondan a comunidades de habla diferentes ha revelado sesgos interesantes en la manera en que cada comunidad asocia las formas Perfecto Simple y Compuesto a los contextos de habla específicos. Esto nos ha permitido mostrar y explicar un hecho esencial del lenguaje y es que los paradigmas de una lengua tienen ‘juego’ (Martínez 2010, 2012) es decir, que existen desplazamientos entre distintas variedades de una lengua y que esto responde a que cada variedad consolida sistemas gramaticales fuertemente ligados a la mirada que tienen sobre el mundo.
À sombra das crônicas imortais
Authors: Sansevero Bernardo
Published: May 2022

Meu objetivo neste artigo é trazer as crônicas de Nelson Rodrigues sobre futebol para um lugar de destaque com a defesa de sua “imortalidade”, contrariando uma visão comum que as enxerga como um mero apêndice da consagrada obra rodrigueana. Faço isto com base na estética de Kant, para quem o belo é algo que dá muito a pensar, sempre suscitando novas reflexões, uma vez que nenhuma explicação consegue abarcar por completo a forma bela e a rica matéria da obra de arte. Defendo o caráter “imortal” da crônica esportiva de Nelson Rodrigues em duas etapas: primeiro mostro que a forma de escrita presente em toda a obra rodrigueana (sua crônica não-esportiva, os romances e teatro) atravessa também seus textos sobre futebol, fazendo com que possuam, além de uma matéria específica (o futebol), uma forma estética que por si só gera um encantamento com a obra; e na segunda etapa (2) defendo que o assunto de suas crônicas esportivas, o futebol, traz consigo uma rica matéria estética, uma vez que este passa a ser entendido a partir de seu traço fundamental, sua inexplicabilidade, decisiva para a sustentação do caráter “imortal” da crônica esportiva de Nelson Rodrigues.
Karakteristik Kimiawi dan Total Bakteri Asam Laktat (BAL) Kecap Ikan Tandipang (Dussumieria sp.) dengan Penambahan Ekstrak Buah Nanas
Authors: Makanoneng Gabriella Amelia , Mentang Feny , Dien Henny Adeleida , Onibala Hens , Palenewen Joyce Christiana Valencia , Makapedua Daisy Monica
Published: May 2022

The purpose of this study was to obtain a formula of rainbow fish sauce with pineapple extract and to determine the effect of adding pineapple extract on the fermentation process and total lactic acid bacteria. With the addition of 0%, 5%, 10%, 15%, and pineapple extract treatment and fermented for 7, 14, 21 days in an incubator with a temperature of 40-50 ℃. The test parameters are Sensory Analysis which includes appearance, aroma, and viscosity (SNI 01-2346-2006), pH (AOAC, 2005), total lactic acid bacteria. The results of the sensory test research for the appearance of the 5% sample, 15% aroma, 10% viscosity with a fermentation time of 21 days were the most preferred by panelists with an average value of 6.8, 6.4, 7. The average pH value on day 7 ranged from 6.77 to 6.67, day 14 ranges from 6.67 to 6.59, day 21 ranges from 6.40 to 6.35. The test results of the highest colony Lactic Acid Bacteria in the sample with the addition of pineapple extract as much as 15% fermentation on the 21st day with a total colony number of 1.46 × 10³ CFU / ml.
Pengaruh Ekstrak Kulit Manggis terhadap Mutu Ikan Cakalang Asap
Authors: Gusu Jahara , Onibala Hens , Pongoh Jenki , Taher Nurmeilita , Dotulong Verly , Mentang Feny , Sanger Grace
Published: May 2022

Tujuan Penelitian ini untuk mendapatkan ekstrak kulit buah manggis yang dikeringkan selama 4 dan 8 hari sebagai bahan pengawet dan melihat pengaruh tingkat kesukaan konsumen terhadap ikan cakalang (Katsuwonus pelamis L.) asap yang direndam dalam ekstrak kulit buah manggis. Data hasil pengamatan uji organoleptik yang tertinggi terdapat pada Aroma dengan nilai 8,1 pengeringan 8 hari dengan perendaman 15 menit (A2B1) dalam penyimpanan 0 hari dan data hasil uji organoleptik yang terendah terdapat pada Rasa dengan nilai 2,5 pengeringan 4 hari dengan perendaman 30 menit dalam penyimpanan hari ke-10. Hasil penelitian TVB-N menunjukkan bahwa larutan kulit buah manggis dengan penyimpanan 0 hari sampai hari ke-10 sudah diatas Standarisasi Nasional Indonesia (SNI) sehingga sudah tidak layak untuk dikonsumsi.
Upaya Guru PAI Dalam Membentuk Karakter Tanggung Jawab Siswa Di SMP Negeri 1 Ploso Jombang
Authors: Nisa' Khoirun , Astari Nurie
Published: May 2022

Tujuan penelitian ini adalah untuk mengetahui upaya guru pendidikan agama islam, faktor pendukung dan penghambat, dam solusi mengatasi hambatan dalam membentuk karakter tanggung jawab siswa di SMP Negeri 1 Ploso.1. Metode penelitian ini adalah penelitian lapangan dengan melihat masalah yang dikaji dengan melalui pendekatan kualitatif. Jenis penelitian yang digunakan dalam penelitian ini yaitu deskriptif. Hasil penelitian menunjukkan bahwa upaya guru PAI dalam membentuk karakter tanggung jawab dalam pembentukan karakter tanggung jawab pada peserta didik waka kesiswaan mempunyai beberapa pencapaian antara lain : memahami perbedaan karakter peserta didik, memerlukan waktu tersendiri dan bertahap, mengedepankan tanggung jawab, memberikan motivasi dan nasehat , keteladanan, intervensi, terintegrasi upaya guru pai dalam pembentukan karakter tanggung jawab memahami perbedaan karakter peserta didik, memerlukan waktu tersendiri dan bertahap, mengedepankan tanggung jawab , memberikan motivasi dan nasehat, pemberdayaan yang dimaksud dengan pemberdayaan, keteladanan, intervensi, terintegrasi. Penelitian ini berkontribusi terhadap isu-isu Pendidikan karakter khususnya karakter tanggungjawab dalam diri anak.
IMPACT OF PREGANCY RELATED ACUTE KIDNEY INJURY IN MATERNAL HEALTH IN CENTRAL INDIA- A CASE SERIES
Authors: Kumar Gupta Anil , Jamra Yogendra , Porwal Monika
Published: May 2022

Many pregnancies associated diseases are adding to the development of Pregnancy Related Acute
Kidney Injury (PR-AKI) like Pre-Eclampsia/Eclampsia (PE/E), HELLP Syndrome, Antepartum/Postpartum
Hemorrhage (APH/PPH) and Pregnancy Associated Thrombotic Microangiopathy (P-TMA) are common. Puerperal sepsis, septic
abortion, Pre-Eclampsia/Eclampsia, HELLP Syndrome, Antepartum and Postpartum Hemorrhage are common risk factors for
PR-AKI development. PR-AKI patients have adverse impact on the maternal health and may leads to development of CKD even
death.
THE EFFECT OF KIND OF MEDIA ON F0 AND F1 BUTTON MUSHROOM SPAWN GROWTH
Authors: Rahayu Siska , Aiman Umul , Dinarto Wafit
Published: May 2022

Quality spawns are an important factor to support the success of button mushroom cultivation. The
quality of mushroom spawn is inuenced by the nutritional composition of the media. The purpose of this
study was to determine the best media for the growth of F0 and F1 button mushroom. The research was carried out in March-May
2021 at the Biology Laboratory, Faculty of Agroindustry, University of Mercu Buana Yogyakarta. The study consisted of 2 series of
experiments. This study consisted of 2 series of experiments. The rst experiment was to test the growth quality of F0
champignon on 3 types media, that is potato dextrose agar (PDA),mung been sprout extract media, and white sweet potato
media. The second experiment tested the growth quality of F1 button mushroom grown on three types of media, that is corn,
barley and sorghum. Both experiment were single factor trials arranged in a completely randomized design (CRD) with three
replications, and each replication consisted of 5 units. The results showed that the growth of F0 button mushroom grown on PDA
media and mung bean sprout extract was better than white sweet potato extract media. For the growth of F1 button mushroom,
the best media was corn, the second was sorghum and the third was barley.
MORPHOLOGICAL STUDY OF JUGULAR FORAMEN IN HUMAN ADULT NEUROCRANIUM
Authors: Vidya Lakshmi Kanna Naga , P Amarnath , K Padmavathi.
Published: May 2022

AIM: To evaluate bilateral morphological features of the Jugular Foramen in human adult skulls.
Material and methods: Study was conducted in 50 crania(unknown sex) of Indian origin. Morphological
features of the Jugular foramen studied in detail like likeDome (presence/ absence),Septa(presence/ absence) & Type of septa
(complete/ incomplete) were noted and are the values are compared with the earlier literature.
OBSERVATIONS & RESULTS: Morphology of the jugular foramen is observed for Dome (presence/ absence),Septa(presence/
absence) & Type of septa (complete/ incomplete).Mean Dimensions for the right side (APD, MLD& AREA) were 11.8+
2.03mm,15.7+2.42mm, 141.45+41.18mm and the left side were 11.3+ 1.85mm,13.72+ 2.31mm ,120.41+36.24mm respectively
CONCLUSION:. In depth knowledge on morphological features of the jugular foramen could assist the neurosurgeons and the
radiologists
ALLOPURINOL INDUCED ADVERSE DRUG REACTIONS: CASE SERIES
Authors: K. Mulchandani Dheeraj , Sharma Chetan
Published: May 2022

Allopurinol is widely used drug for patients of hyperuricemia and gout. The few adverse drug reactions
related to allopurinol are diarrhea, fever, hepatotoxicity, Steven Johnson Syndrome- Toxic Epidermal
Necrolysis (SJS-TEN), congestive heart failure and renal failure. In this article we have described eleven cases to evaluate the
causality, cause and management of this syndrome. In this study eleven retrospective cases were selected from the ADR reports.
The full details of the cases were collected from Christian Medical College from the period of 2012 to 2016. Causality was
established using Naranjo scale and classication was done based on severity and resolution of ADR. It was observed that
cases presented with mild to severe reactions of allopurinol, which is the suspected offending agent. Cases were resolved with
supportive treatment while ve case had a prolong hospitalization and two cases had a life threatening drug reaction. Early
detection and management of this severe form of systemic reaction is very important for better will be the prognosis.
GUILLAIN-BARRÉ SYNDROME FOLLOWING COVID-19: A NEWLY EMERGING COMPLICATION
Authors: C P Ganesh , Pahel Meitei Soibam , Rebika Devi Takellambam , Lalremmawi Hannah
Published: May 2022

BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-cov-2) is causing a worldwide
pandemic of COVID-19. As case numbers increase, the body of research around SARS-cov-2 and the
pathophysi- ology of the disease process it causes (COVID-19), expands daily. Patients with COVID-19 typically present with
fever and respiratory illness; however, a wide range of other symptoms have been described. While the neurological sequelae of
the virus remain poorly understood, there are a growing number of reports of neurological manifestations of COVID-19.A recent
study from Wuhan reported that 78 (36.4%) out of 214 patients admitted with COVID-19 had neurological symptoms ranging
from anosmia and taste disturbances to cerebrovas- cular to strokes and seizures.
Additionally, there is increasing recognition Of a link between COVID-19 and Guillain-Barré syndrome (GBS), with three
international case reports and one case series of ve patients are the only published cases to date. To help add to this small but –
developing body of evidence, this is the rst published case of GBS secondary to COVID-19 in the North east India
PREDICTIVE CORRELATION OF ADVERSE CLINICAL OUTCOMES WITH THROMBOCYTOPENIA IN DENGUE FEVER: A SINGLE CENTER EXPERIENCE
Authors: Thakura Manisha , Chauhan A , Jambunathan Prashant , Awasthid Shikha , K Thilagavathi
Published: May 2022

Background: Dengue fever is the most widely distributed viral infection in the world with more than 100
million people affected. In this study we attempt to study the co-relation between the nadir of the platelet
count and the onset of warning signs (persistent pain abdomen and vomiting, mucocutaneous bleed or clinical uid
accumulations). A positive co-relation in between these two elements could help predict onset of shock and third spacing and
facilitate prognostication and early intervention.
Methods: We studied 82 patients with a diagnosis of dengue fever, the basis of which was clinical signs and symptoms with a
positive NS1 antigen test. The nadir of thrombocytopenia and rise in transaminases were studied along with onset of various
warning signs.
Results:The nadir of thrombocytopenia correlates with onset of warning signs such as clinical uid accumulation (two tailed P
value <0.002) and mucosal bleed (two tailed P value <0.001). However, the rising value of transaminases does not co-relate
statistically with onset of warning signs in Dengue fever.
Conclusions: The age of patients ranged from 18 to 60 with 23 out of 83 (27.7%) being in the 30-40 years age group. Clinical uid
accumulation was seen in 54 (64.7%) patients, mucosal bleed in 61 patients (74.3%) and liver was palpable more than 2 cm in
28 patients (33.7%). The importance of serial monitoring of platelets is important not only for the prediction of severe dengue,
but also with the onset of other warning signs such as clinical uid accumulation. This nuanced fact re-enforces the critical
importance of platelet count predict other warning signs which contribute to morbidity and mortality in dengue fever.
ALVEOLAR RHABDOMYOSARCOMA: PRESENTATION OF A CASE AND REVIEW OF THE LITERATURE
Authors: Muñoz Murillo Jessica Alejandra , Jaime Aguirre Andrea Carolina , González Pinilla Andres Mauricio , Ramirez Munõz Daniel Santiago , Cardenas Casallas Jonathan Gerardo , Martos Narváe Marly Yonency , Chamorro Garcia Yesid
Published: May 2022

Rhabdomyosarcoma (RMS) is a rare type of soft tissue malignant neoplasm that currently represents
about 7% of cancers in children, it is found in a much smaller proportion in adults, which represents about
1% of cancers, the global incidence of RMS is 4.5/million people under 20 years of age. Alveolar rhabdomyosarcoma (ARMS) is a
widely studied subtype in minors and very rarely in adults. The most common presentation in extremities is of the alveolar
subtype, most frequently affecting the lower extremities.
We present a narrative review based on a case report of a patient with alveolar rhabdomyosarcoma in a lower extremity
DENTAL ORAL HEALTH - ATTITUDE, BEHAVIOR, KNOWLEDGE AMONG DENTAL STUDENTS IN SOUTHERN RAJASTHAN DENTAL COLLEGE
Authors: Chowdhery Divya
Published: May 2022

Background: Attitude and Knowledge of dental student towards Dental oral health plays a crucial role in
for delivering a good dental service in total.
Objectives: The objective of the study is to determine and compare the Dental oral health attitude, behavior, knowledge among
dental students.
Methodology: A cross-sectional survey of 155 dental students from third year, nal year and internship was conducted from
Department of Public Health Dentistry, Pacic dental college &Research centre Udaipur. A self-administered questionnaire was
used to conduct the survey. Convenience sample was the chosen method of sampling.
Results: On an average the knowledge obtained by the students about oral health is 73% and their attitude towards
maintaining their personal oral hygiene is 61%.
Conclusion: It has been found that the knowledge in oral health increased over years of awareness programe and education
and the implementation of this knowledge in improving their personal oral hygiene was satisfactory
The educational value, both past and present, of an ancient scientific collection: the collection of anatomical preparations illustrating the various phases of bone development, from the second month of intrauterine life to adulthood
Authors: Martini Mariano , Aglianò Margherita , Orsini Davide
Published: May 2022

Italy’s museums possess an enormous patrimony of historical scientific artefacts. This raises important questions regarding the conservation and safeguard of such materials and prompts reflection as to the utility of current modalities of popularising science. The collections housed in scientific museums were created in order to promote scientific education by making science more accessible and more comprehensible. The authors ask whether this heritage can still be used for educational purposes today, and examine a collection of preparations on the ossification of human bones in the Anatomical Museum of the University of Siena. They conclude that such materials can still be of educational value if they are made part of exhibitions that meet the needs of the public and of students in training. Indeed, it is essential to bear witness to the long pathway of the development of scientific knowledge and, in particular, to the value of the research on which this knowledge is based. Through the implementation of ad hoc exhibitions, this precious historical scientific patrimony can continue to play an important role in presenting medical/healthcare issues of topical interest without losing sight of the relevance of past experience to basic teaching.
INTERFERÊNCIA NO PAR LINGUÍSTICO PORTUGUÊS-ESPANHOL: UM ESTUDO SOBRE A NASALIDADE EM TEXTOS ESCRITOS POR VENEZUELANOS
Authors: Mota Fabricio Paiva
Published: May 2022

O contato linguístico é a relação entre duas ou mais línguas em uma mesma localidade, as quais compartilham espaços comuns, tais como áreas de comércio e de educação, principalmente em áreas fronteiriças. Roraima faz fronteira com dois países: Venezuela e Guiana. O objetivo geral desta tese é analisar as interferências linguísticas presentes em produções textuais de venezuelanos aprendizes de português na fronteira Brasil/Venezuela. Para este artigo, fundamentamo-nos em Weinreich (1974 [1953]), Silva-Valdivia (1994) e Siguan (2001) para definir interferência. Os autores a conceituam como a influência de uma língua A sobre uma língua B, o que resulta em estruturas que não pertencem ao sistema gramatical de nenhuma das línguas envolvidas. A coleta dos dados aconteceu entre os anos de 2015 e 2017 em um curso de português para estrangeiros na fronteira Brasil/Venezuela. O corpus foi composto por 47 redações escritas por 23 venezuelanos. Para este artigo, selecionamos as interferências correspondentes a nasalidade e podemos concluir que os informantes ora grafam -n ora grafam -m em contexto de final de palavra. Ao grafar -n, o informante marca apenas esse elemento como sendo de sua língua materna, pois o radical da palavra está em português.

Palavras-chave: Contato linguístico. Interferência linguística. Português como Língua Estrangeira.
Ed Cooper, Rule 56, and Charles E. Clark's Fountain of Youth
Authors: Gensler Steven
Published: May 2022

Nobody had a greater impact on the formulation of the original Civil Rules than Clark. His role as both the principal architect and the principal draftsman of the Civil Rules is well known. As Professor Wright once put it, although the Civil Rules were a joint effort, "the end product bears the unmistakable Clark stamp." But Clark started shaping the Civil Rules even before drafting began. Initially, Chief Justice Hughes thought the civil rules project should be limited to creating rules for actions at law (leaving in place-and separate-the existing equity rules). A passionate advocate for merging law and equity procedure, Clark mounted a multi-front campaign to get the Court to change its course. His campaign succeeded. Clark also succeeded in persuading the Court to adopt a centralized drafting process, with the work to be done by a select group of experts, many of whom Clark himself recommended. Finally, Clark maneuvered to be named Reporter, a position that no doubt contributed to the Civil Rules bearing his stamp. In this Essay, however, I want to focus not on the events that led up to the 1938 rules but on what happened after they took effect. Was the work of the Advisory Committee done? Did the Advisory Committee even exist anymore? If so, what was the Committee's assignment? It should come as no surprise that, just as Clark had strong views about the initial drafting of the rules, he also had strong views about how they should be superintended. Clark lobbied for the creation of a standing Advisory Committee, and he wrote extensively about what the work of the Committee should be. In one capacity or another, Clark continued to toil in the rulemaking fields for another twenty-four years until his death in 1963. This Essay proceeds in three parts. Part I looks back at the development of the institution of the standing Advisory Committee. It tells two stories. First, it provides a quick history of what the Advisory Committee did after 1938 and how it came to be in its current form. Second, it sets forth Clark's very influential views about what role a standing Advisory Committee should play. Part II returns us to modern times. It analyzes the most recent set of major amendments to the Civil Rules-the 2010 amendments to Rule 56-to see how that project relates to Clark's views on the continuing rulemaking process. Part III concludes with a few reflections on Ed's role in advancing some of the rulemaking values that Clark held so dear.
Professor Ed Cooper: Zen Minimalist
Authors: Mullenix Linda
Published: May 2022

In celebration of his twentieth year as the Reporter for the Advisory Committee on Civil Rules, I write to contribute some modest reflections on Professor Cooper's tenure as Advisory Committee Reporter. My comments are those of an academic who had the opportunity to observe the Advisory Committee for nearly a decade, but they are largely the comments of an outsider. Readers might be disappointed to find that there is no dish or inside baseball here.
Shoes That Did Not Drop
Authors: Marcus Richard
Published: May 2022

I take "Shoes That Did Not Drop"' as my topic because I appreciate, by now, that what the Advisory Committee on Civil Rules does not do is, in some ways, as important as what it does. Similarly, the decision not to do something is equally important as, and may be more difficult than, the decision to do something. It may sometimes seem that amending the Rules is too easy. Greg Joseph once said that they are amended as often as the telephone book.2 Some even think that it was a mistake to create a Rules Committee.3 These reactions are overstated, however. Amendments do not and should not happen often. Amending the rules is not easy and should not be.
They Were Meant for Each Other: Professor Edward Cooper and the Rules Enabling Act
Authors: Kravitz Mark , Levi David , Rosenthal Lee , Scirica Anthony
Published: May 2022

This introduction to the essays in this Symposium illuminates Professor Ed Cooper's years as Reporter to the Civil Rules Committee by first briefly describing those who preceded him in the position and his own background. We then describe some of Ed Cooper's many contributions to the Civil Rules Committee, the Federal Rules, rulemaking, and civil procedure by examining the present state of the Rules Committees' work under the Rules Enabling Act. We conclude that after almost eighty years of experience under that Act, it is working well in large part because of the sound leadership provided by Ed Cooper over his twenty years as Reporter. It was during these years that the Committee developed an approach to rulemaking that was at once transparent and empirical, with multiple opportunities for participation by members of the public, the bench, the academy, and the bar; with many informal opportunities for consultation with members of Congress and the Executive Branch; and with an understanding by the Committee of its role in relation to the courts, Congress, and the Executive. Two episodes of recent rulemaking and related activity are described as examples of how well the Rules Enabling Act is working, in large part because of the very flexibility and discretion the Act has provided since 1934. One of those episodes occurred when Judge Anthony Scirica chaired the Standing Committee and then- Judge David Levi chaired the Civil Rules Committee. The other occurred when Judge Lee Rosenthal and Judge Mark Kravitz were the chairs of the Standing and Civil Rules Committees, respectively. Both episodes provide a basis for optimism about the future. And they make clear Ed Cooper's continued steady role in supporting and cultivating the robust good health of the rulemaking process and the institutional values it protects.
Toward Comprehensive Reform of America's Emergency Law Regime
Authors: Thronson Patrick
Published: May 2022

Unbenownst to most Americans, the United States is presently under thirty presidentially declared states of emergency. They confer vast powers on the Executive Branch, including the ability to financially incapacitate any person or organization in the United States, seize control of the nation's communications infrastructure, mobilize military forces, expand the permissible size of the military without congressional authorization, and extend tours of duty without consent from service personnel. Declared states of emergency may also activate Presidential Emergency Action Documents and other continuity-of-government procedures, which confer powers on the President-such as the unilateral suspension of habeas corpus-that appear fundamentally opposed to the American constitutional order. Although the National Emergencies Act, by its plain language, requires Congress to vote every six months on whether a declared national emergency should continue, Congress has done so only once in the nearly forty-year history of the Act. This Note and an accompanying online compendium attempt, for the first time since the 1970s, to reach a reasonably complete assessment of the scope and legal effects of the thirty national emergencies now in effect in the United States. The Note also proposes specific statutory reforms to rein in the unchecked growth of these emergencies and political reforms to subject the vast executive powers granted by the U.S. emergency law regime to the democratic process.
What the Awards Tell Us about Labor Arbitration of Employment Discrimination Claims
Authors: Levinson Ariana
Published: May 2022

This Article contributes to the debate over mandatory arbitration of employment-discrimination claims in the unionized sector. In light of the proposed prohibition on union waivers in the Arbitration Fairness Act, this debate has significant practical implications. Fundamentally, the Article is about access to justice. It examines 160 labor arbitration opinions and awards in employment-discrimination cases. The author concludes that labor arbitration is a forum in which employment-discrimination claims can be-and, in some cases, are-successfully resolved. Based upon close examination of the opinions and awards, the Article recommends legislative improvements in certain cases targeting statutes of limitations, compulsory process, remedies, class actions, discovery, and a union's duty of fair representation.
Concepcion's Pro-Defendant Biasing of the Arbitration Process: The Class Counsel Solution
Authors: Korn David , Rosenberg David
Published: May 2022

By mandating that numerous plaintiffs litigate their common question claims separately in individual arbitrations rather than jointly in class action arbitrations, the Supreme Court in AT&T Mobility LLC v. Concepcion entrenched a potent structural and systemic bias in favor of defendants. The bias arises from the parties' divergent stakes in the outcome of the common question litigation in individual arbitrations: each plaintiff will only invest to maximize the value of his or her own claim, but the defendant has an incentive to protect its entire exposure and thus will have a classwide incentive to invest more in contesting common questions. This investment advantage enables the defendant to wield superior litigation power against each plaintiff skewing the outcome of individual arbitrations in its favor and frequently rendering claims not worth filing. Concepcion perpetuates the bias by precluding the use of a class arbitration solution. We propose that courts neutralize the Concepcion bias by appointing class counsel to represent each plaintiff in individual arbitrations. Without threatening Concepcion's holding that arbitral efficiency precludes class arbitration unless the parties specify otherwise, the class counsel solution equalizes the parties' investment incentives to transform individual arbitrations into a socially useful legal system for promoting the deterrence, compensation, and other public policy objectives of federal and state substantive law.
The Future of Classwide Punitive Damages
Authors: Sharkey Catherine
Published: May 2022

Conventional wisdom holds that the punitive damages class action is susceptiblenot only to doctrinal restraints imposed on class actions but also to constitutionaldue process limitations placed on punitive damages. Thus, it would seem that theprospects for punitive damages classes are even grimmer than for class actionsgenerally.This conventional picture misunderstands the role of punitive damages and, inparticular, the relationship between class actions and punitive damages. It eitherignores or underestimates the distinctly societal element of punitive damages, whichmakes them especially conducive to aggregate treatment. Furthermore, punitivedamages classes offer a solution to the constitutional due process problem of juriesawarding "classwide" damages in a single-plaintiff case.Courts' conceptualization of punitive damages as either individualistic or societaldictates how they decide the certification question. My survey of recent case lawreveals that courts taking the plaintifffocused individualistic view of punitivedamages tend to deny class certification, while courts embracing the defendantfocusedsocietal view are more likely to certify a punitive damages class, all elsebeing equal. Therefore, the viability of the punitive damages class depends upon thepersuasiveness of the societal conception of punitive damages.Based on this empirical grounding I discuss two possibilities for reform. First, statelegislatures and courts could affirmatively define the collectivized, societal rationalefor punitive damages. Such state legislative measures would likely withstand constitutionalscrutiny under Philip Morris USA v. Williams, given the U.S.Supreme Court's reaffirmation of the primacy of the state's role in defining thelegitimate purposes of punitive damages. Second, federal courts-in the absence ofdefinitive guidance from authoritative sources on state substantive law-couldconsider the underlying societal rationale for punitive damages in the course oftheir certification decisions. To do so would not only be permitted, but indeed warranted,by the Rules Enabling Act.
The Future of Securities Class Actions against Foreign Companies: China and Comity Concerns
Authors: Muir Dana , Liu Junhai , Xu Haiyan
Published: May 2022

In Morrison v. National Australia Bank Ltd., the U.S. Supreme Court limited the application of U.S. securities fraud law in transnational situations. The Supreme Court noted that its decision was influenced by international comity considerations. In this Article, we evaluate the availability of class actions in China in cases involving alleged securities fraud. Because we find that the availability of those actions is too limited to fully protect U.S. shareholders, we argue that U.S. investors should be permitted to bring securities fraud class actions against non-U.S. companies whose securities are traded on a U.S. exchange regardless of where those investors entered into the relevant securities transactions.
ANALISIS SALAH SATU OBAT HERBAL DI SUMATERA UTARA TAHUN 2021
Authors: Tambusai Christivo , Nerdy Nerdy , Fahdi Firdaus
Published: May 2022

The existence of competition between chemical and traditional drugs has resulted in increasingly being displaced from the market. In addition, another problem that traditional medicine has not been widely used for both self-medication and formal health services is that most of the efficacy of traditional medicine has not been scientifically tested. Therefore, it is very important to do an analysis through research. The purpose of this study was to determine the efficacy of traditional medicine PT. Amanah Berkah Kencana in improving health and body immunity. The research method used in this study is a descriptive method with a cross- sectional  approach.  The  main  informants  in  this  study  were  consumers  of traditional medicine PT. Amanah Berkah Kencana. This research was conducted in North Sumatra from December 2021 to February 2022.
The results of the study explain that 82.5% strongly agree. The results of this percentage show a very good picture for consumers who use Haseda traditional medicine in maintaining health and increasing human immunity. The remaining
17.5% do not agree because of lack of public education and knowledge about the use and benefits of traditional medicine for health.
For health observers, there should be socialization to the public about the use of traditional medicines.
FORMULASI SEDIAAN MASKER Gel Peel Off EKSTRAK ETANOL DAUN JAMBU BIJI (Psidium Guajava L.) SEBAGAI PEMBERSIH WAJAH
Authors: Tarigan Palas
Published: May 2022

Guava plants contain psiditanin “eugenol” essential oil, tannis, flavonoids, saponins, alkaloids. Compounds that have very good strength come from the class of flavanoids, vitamin C which can be usedas a facial cleanser. This study aims to determine the preparation of peel gel mask of guava leaf extract is effective as a facial cleanser and to find out the peel off gel mask of guava leaf extract can irritate the skin of volunteers. The made with 4 formulation with concentrations of 0%, 10%, 15%, 20%. The testing of the peel off gel mask formulation ethanol extract on cleanliness was carried out with the analysis of the ms. Excel bar diagram. The results showed that (psidium guajava L) contain flavonoid, alkaloids, tannins and saponins. The results of the characteristics of the simplicia powder were 5,42% water content 9,56% total ash content 0,34% acid insoluble ash, ethanol soluble extract 64,295. The results of the peel off gel mask formulation test with a cleanliness test on the panelists facial skin concentration of 15% included in the category can clean the panelist’s facial skin.Guava leaf ethanol extract has a facial cleansing activitywith a score of 3