bluuebunny/crossref_metadata_2025 huggingface dataset:
Electric Field-Based Cancer Therapy Induces the Expression of HMGB1 and PD-L1 mRNA Genes on Breast Tumor of Female Rats
Authors: Fathurrohmah Siti , Cahyadi G.A.B Yehezkiel P. , Alamsyah Firman , Pratiwi Rarastoeti
Published: November 2022

Electro Capacitive Cancer Therapy (ECCT) is an electric field-based cancer therapy method using intermediate frequency (150 kHz) and low intensity (18 Vpp). High Mobility Group Box 1 (HMGB1) is a cytokine related to damage-associated molecular patterns (DAMPs) secreted by dead cells. The expression of Programmed Death Ligand 1 (PD-L1) is ligand present on the surface of tumor cells and its expression is associated with the increase in the number CD8+ T lymphocytes. This study aims to examine the effect of ECCT exposure on the expression of HMGB1 and PD-L1 genes on the breast tumor, brain, and liver tissues of Rattus norvegicus (Berkenhout, 1769). The tissues were obtained from the previous studies stored in RNAlater (-20˚C). Female rat tissues of the previous study from four treatment groups, namely the control group (NINT), non-DMBA-induction with therapy (NIT), DMBA-induction with non-therapy (INT), and DMBA-induction with therapy (IT). Gene expression was analyzed using the RT-qPCR. Statistical t-test with a p<0.05 significance level was performed using GraphPad Prism 9.4.0 software. The result shows HMGB1 and PD-L1 mRNA genes were both significantly expressed in breast tumor samples. The liver and brain samples of normal rats did not show any significant changes in the activity of these genes after exposure to the electric field. This study indicates that exposure to electric fields may trigger the expression of HMGB1 and PD-L on the rat’s breast tumor samples. This study also provides information related to the safety of ECCT in healthy organs of female rats, especially the brain and liver.Keywords: ECCT, breast tumor, HMGB1, PD-L1, IFN- γ.
Supplementation of guanidinoacetic acid in feed with different levels of protein on intestinal histomorphology, serum biochemistry, and meat quality of broiler
Authors: Rahmawati D. , Hanim C.
Published: November 2022

This study aimed to investigate the effect of guanidinoacetic acid (GAA) with different protein levels in feed on intestinal histomorphology, serum biochemistry, and meat quality of broiler chicken. GAA is the only direct precursor of creatine and is involved in the synthesis of bioenergy cellular. This research used 1.176 day-old chicks of the Lohmann Indian River strain that were reared for 35 days. The supplementation effect was investigated using six treatments, i.e., two levels of feed protein and three levels of GAA, with seven replications. Broiler chickens were fed with 23% and 21% crude pro-tein during the pre-starter phase, 21% and 19% during the starter phase, and 19% and 17% during the finisher phase, with a GAA addition of 0 g/ton, 600 g/ton, and 1200 g/ton, respectively. The result showed GAA supplementation with different protein levels reduced triglyceride (P<0,05), cholesterol levels in serum (P<0,05), increased surface area of the microvilli (P<0,05), pH of breast meat (P<0,05), but did not affect the chemical quality of breast meat (P>0,05). In conclusion, GAA supplementation in different level protein diets increased the surface area of the microvilli, pH of breast meat, reduce se-rum cholesterol and triglycerides, without affecting the chemical quality of broiler meat.
Effect of feeding level on growth rate, carcass characteristics and meat quality of thin tailed lambs
Authors: Luthfi N. , Adiwinarti R. , Purnomoadi A. , Rianto E.
Published: November 2022

A study was conducted to investigate the growth rate and carcass characteristics of lambs under different feeding levels. Twenty one lambs (3 months old) were allocated into 3 treatments of feeding levels, namely 4% of body weight (BW) (T1), 5.5% of BW (T2) and provided ad libitum (T3). The diet contained 13.74% of CP and 61.79% of TDN. The lambs were raised to reach 25 kg BW, before being slaughtered. The parameters observed were dry matter intake (DMI), dry matter digestibility (DMD), body weight gain (BWG), feed conversion ratio (FCR), carcass production, meat-bone ratio (MBR), fat distribution, chemical composition of meat and fatty acids profile. The data obtained were analyzed by analysis of variance and continued by Duncan's multi-range test if there was any significant difference among the treatments. The results showed that the average of DMD was 59.71% (P>0.05). The lambs fed T3 had the highest BWG (203 g/day), the lowest FCR (6.8) and the shortest rearing time (67 days) (P<0.01). The average of carcass percentage was 46.36% and meat production was 6,931 g (P>0.05). The lambs of T3 had the heaviest carcass fat (2,698 g), the lightest carcass bone (1,985 g), the highest MBR (3.6), and the highest PUFA to SFA ratio (0.55). It can be concluded that the higher the feeding level resulted in the higher growth rate, the lower feed conversion ratio, higher meat-bone ratio and higher carcass fat production, lower feed conversion ratio and the shorter rearing time; but did not af-fect the meat quality.
Kosmiczny kontekst ewolucji biologicznej i jego konsekwencje filozoficzno-teologiczne
Authors: Leciejewski Sławomir
Published: November 2022

W artykule opiszę kosmiczny kontekst ewolucji biologicznej i jego konkretyzację w postaci różnych sformułowań zasad antropicznych (słabej, mocnej, probabilistycznej, ostatecznej i partycypacyjnej), aby przejść do omówienia wybranych filozoficznych oraz teologicznych konsekwencji antropiczności Wszechświata. Celem artykułu jest odpowiedź na pytanie, czy fakt antropiczności Wszechświata prowadzi do możliwości uzasadnienia tez o ontologicznym, epistemologicznym oraz teologicznym charakterze.
Was sahen, hörten und rochen die römischen Soldaten? Versuch einer multisensorischen Rekonstruktion römischer Kriegserfahrung
Authors: Diemke Justine
Published: November 2022

Der Beitrag untersucht die multisensorische Wahrnehmung römischer Soldaten. Entgegen der landläufigen Meinung, dass die Soldaten aufgrund der vorausgegangenen Gewöhnung an derartige Kriegsgewalt resilienter waren, kann der Beitrag zeigen, dass die Gewalt auf dem Schlachtfeld die Soldaten durchaus psychisch belastete. Zur visuellen Aufnahme der Toten, Verletzten und dem furchterregenden Habitus der Feinde gesellte sich die Kakophonie des feindlichen Gesanges und des Geschreies, welche die akustische Wahrnehmung der Soldaten stark beeinträchtigen konnten. Obwohl die sensuellen Erfahrungen von Topoi überlagert sind und ihre Schilderung primär der Emotionserregung des Lesers dienen, ermöglichen sie wichtige Rückschlüsse auf die individuelle Kriegswahrnehmung der Beteiligten. So waren die Soldaten einer permanenten Reizüberflutung und unterschiedlichen Emotionen, in erster Linie der Angst, ausgesetzt, was die Entwicklung einer psychischen Störung fördern konnte.
When a Crisis Empties Mosques: A Case Study of Muslim Responses to the Pandemic’s Challenges in Regards to Spiritual Care and Communal Rituals in Austria and Germany
Authors: Abdallah Mahmoud
Published: November 2022

Cases from both Germany and Austria exemplify how the COVID-19 pandemic is rapidly changing traditionally held ideas of Islamic community, religious congregations, and pastoral care. These cases were collected during Ramadan 2020, as this particular period signifies a time of paramount spirituality, social solidarity, and communal festivity. They reflect the rich and vibrant efforts and responses of Muslim leaders, organizations, and institutions to the challenges posed by the current pandemic. Different initiatives and solutions Muslim communities have developed as a response to COVID-19 are characterized as “caring communities.” Muslim chaplains, despite their highly limited personal access to secluded, lonesome, and distressed individuals in need of support, overcame the restrictions. Muslim leaders have striven to make use of the virtual space to fulfil the ordinary function of mosques as places of worship and communication. They have thus attempted to uphold social solidarity (zakat). Their responses to the pandemic raise questions about the future of religiosity and its manifestation as well as possible forms of religious communities and their ethical values.
Homo pandemicus – homo solitarius
Authors: Jaworski Krzysztof , Stecko Justyna , Wojtyła Wojciech
Published: November 2022

The purpose of the paper is to analyze the phenomenon of loneliness that was caused by the Covid-19 pandemic. As this is a very broad issue, it was just limited locally to the Polish society, and thematically to the religious aspect. Pandemic loneliness was mainly the result of social isolation to contain the spread of the Sars-CoV-2 coronavirus, causing the Covid-19 disease. In terms of religion, loneliness was caused by separation from public religious practices and the feeling of a lack of Providence. This paper presents three faces of religious loneliness caused by the COVID-19 pandemic: liturgical loneliness, doctrinal loneliness and loneliness related to the feeling of lack of full religious freedom.
White Supremacy as Counter-Telos: Pastoral Formation in the White Habitus
Authors: Senior John E.
Published: November 2022

This paper develops a model of pastoral formation that acknowledges the relentless formative pull of whiteness and centers the work of dismantling white supremacy. It critiques three related framings of pastoral formation: excellence in ministry, pastoral imagination, and Christian practical wisdom. These framings orient pastoral formation around an a-contextual telos or goal, an approach that ultimately reinforces markers of white normativity. Teleological framings of pastoral formation need not be abandoned altogether, but they do require a more nuanced reckoning with white normativity. The paper offers a preliminary re-framing of pastoral formation as a process that requires an ongoing negotiation of the terms of pastoral formation even as practitioners deepen their pastoral expertise, wisdom, and imagination.
Novel photodynamic therapy using two-dimensional NiPS3 nanosheets that target hypoxic microenvironments for precise cancer treatment
Authors: Wu Zongze , Liu Quan , Wageh Swelm , Sun Zhe , Al-Hartomy Omar A. , Al-Sehemi Abdullah G. , Yan Lesen , Chen Jiaojuan , Zhang Wenjian , Yang Jilin , Zhang Han , Liu Liping
Published: November 2022

Photodynamic therapy (PDT) is a highly promising modality against cancer, but its efficacy is severely limited by the low oxygen content in solid tumors. In this study, a smart photosensitive NiPS3 nanosheet was developed to solve the problem of low oxygen to allow PDT to be performed against tumors. The photosensitized ROS generation mechanism of NiPS3 is the photon-generated electron-hole pathway, which can generate O2
·− and ·OH at the conduction band and valance band, respectively. More crucial is that ·OH generation doesn’t need O2, and the O2
·− can also work in a low O2 environment, and depleting oxygen in tumor cells. Modified with triphenylphosphine (TPP) and based on density functional theory (DFT) calculations and experimental data, the NiPS3@TPP nano-system underwent targeted action toward mitochondria. In vitro experiments demonstrated that the reactive oxygen species (ROS) produced by NiPS3@TPP altered mitochondrial membrane permeability, which not only prolonged the PDT effect but also resulted in mitochondria apoptosis pathways inducing an apoptosis cascade. In vivo experiments demonstrated the targeting capability with low toxicity of the NiPS3@TPP nano-system. Tumor targeting at the tested dose indicated that it represented a promising biocompatible photosensitizer for in vivo biomedical applications.
Storage conditions and postharvest practices lead to aflatoxin contamination in maize in two counties (Makueni and Baringo) in Kenya
Authors: Mugure Kamano Hannah , Okoth Michael Wandayi , Makau Wambui-Kogi , Kuloba Patrick , Gitahi Nduhiu
Published: November 2022

Aflatoxins are known to cause devastating acute and chronic effects in humans and animals. The objective of the study was to determine the influence of postharvest practices and storage conditions on aflatoxin contamination in maize in two counties. Aflatoxin levels in 144 maize samples from different maize storage conditions were determined. While sampling, a structured questionnaire was also administered to evaluate farmer’s postharvest practices. Makueni County had the highest percentage of aflatoxin positive samples with up to 174 ppb attributed to the long storage under unfavourable conditions. On the other hand, Baringo County had lower positivity associated with the harvesting season at the time of sample collection. The type of storage condition had a significant effect on the extent of contamination and accounted for 11% of the variation (R
2 = 0.11). Gunny bags were the most common type of storage condition and had the highest level of contamination in both the counties. Metallic bins had the lowest level of contamination. Aflatoxin G1 and G2 were predominant in samples from Baringo County, while aflatoxin B1 and B2 were predominant in samples from Makueni County. The study concluded that the type of storage condition significantly contributes to the aflatoxin contamination in the stored maize. Proper drying of maize to the recommended moisture content and subsequent storage in hermetic structures will reduce the cases of aflatoxin contamination.
Nation-wide decrease in the prevalence of pediatric chronic pain during the COVID-19 pandemic
Authors: Aluko Boluwatife , Mitchell Adrianne N. , Tumin Dmitry , Zeldin Evan
Published: November 2022

Objectives

The COVID-19 pandemic was expected to increase prevalence and severity of chronic pain. We compared pandemic-era and pre-pandemic prevalence of chronic pain among children in the US.

Methods

Data were obtained from the 2019 and 2020 National Survey of Children’s Health, a web-or mail-based survey representative of children living in the US (n=20,359 in 2019; 29,159 in 2020). Caregiver-reported prevalence of chronic pain was compared between survey years using bivariate and multivariable methods.

Results

The prevalence of chronic pain among US children decreased from 11 to 8% in the first year of the pandemic. Multivariable analysis adjusting for children’s and caregivers’ demographics and socioeconomic characteristics confirmed that in 2020, odds of caregiver-reported chronic pain declined by 33% (95% confidence interval: 23%, 42%; p<0.001).

Conclusions

The encouraging finding of a nationwide decrease in the prevalence of chronic pain calls into question initial predictions anticipating the pandemic to contribute to onset or persistence of chronic pain among children.
A new test for non-linear hypotheses under distributional and local parametric misspecification
Authors: Bera Anil K. , Doğan Osman , Taşpınar Süleyman
Published: November 2022

In this paper, we develop a new version of Rao’s score (RS) statistic for testing a non-linear hypothesis under both distributional and local parametric misspecification. Our suggested test statistic is constructed through a size correction approach so that it becomes robust to both types of misspecification. We establish the asymptotic properties of the robust test statistic and provide several examples to illustrate its implementation. We also investigate the finite sample properties of our test along with some other well-known tests through simulations. Our simulation results demonstrate that the new test statistic has good finite sample properties in terms of empirical size and power.
From embedded propositions to complex predicates
Authors: Taine-Cheikh Catherine
Published: November 2022

This article examines verbal sequences in Arabic dialects which can correspond either to complex sentences with embedded clauses or to complex predicates with reduction of one or the other verb. The first part is devoted to complex sentences where completives and subordinates of purpose and consequence are introduced by a marker that is generally specific, but sometimes polyfunctional. The second part explores embedding without a subordinator (with distinct or identical subjects), as well as with cases of complex predicates, sometimes with reduction of V1(cases of auxiliarization and pragmatization), sometimes of V2(rare cases of serial verbs).
SDHx mutation and pituitary adenoma: can in vivo 1H-MR spectroscopy unravel the link?
Authors: Branzoli Francesca , Salgues Betty , Marjańska Małgorzata , Laloi-Michelin Marie , Herman Philippe , Le Collen Lauriane , Delemer Brigitte , Riancho Julien , Kuhn Emmanuelle , Jublanc Christel , Burnichon Nelly , Amar Laurence , Favier Judith , Gimenez-Roqueplo Anne-Paule , Buffet Alexandre , Lussey-Lepoutre Charlotte
Published: November 2022

Germline mutations in genes encoding succinate dehydrogenase (SDH) are frequently involved in pheochromocytoma/paraganglioma (PPGL) development and were implicated in patients with the ‘3PAs’ syndrome (associating pituitary adenoma (PA) and PPGL) or isolated PA. However, the causality link between SDHx mutation and PA remains difficult to establish, and in vivo tools for detecting hallmarks of SDH deficiency are scarce. Proton magnetic resonance spectroscopy (1H-MRS) can detect succinate in vivo as a biomarker of SDHx mutations in PGL. The objective of this study was to demonstrate the causality link between PA and SDH deficiency in vivo using 1H-MRS as a novel noninvasive tool for succinate detection in PA. Three SDHx-mutated patients suffering from a PPGL and a macroprolactinoma and one patient with an apparently sporadic non-functioning pituitary macroadenoma underwent MRI examination at 3 T. An optimized 1H-MRS semi-LASER sequence (TR = 2500 ms, TE = 144 ms) was employed for the detection of succinate in vivo. Succinate and choline-containing compounds were identified in the MR spectra as single resonances at 2.44 and 3.2 ppm, respectively. Choline compounds were detected in all the tumors (three PGL and four PAs), while a succinate peak was only observed in the three macroprolactinomas and the three PGL of SDHx-mutated patients, demonstrating SDH deficiency in these tumors. In conclusion, the detection of succinate by 1H-MRS as a hallmark of SDH deficiency in vivo is feasible in PA, laying the groundwork for a better understanding of the biological link between SDHx mutations and the development of these tumors.
Cognitive Development and Language Acquisition in Autistic Children
Authors: Mostek Jan
Published: November 2022

Autism spectrum disorder (ASD) is typically perceived as a social communication and behavioral disability. However, it is a neurodevelopmental or brain-based condition with widespread consequences on cognitive and social-emotional development caused by genetic events that begin before birth. Cognitive functions of a higher level or those requiring integrative processing are disproportionately hampered in ASD. Normal children can learn any existing language based on their environment; however autistic youngsters find it difficult. The exploration of autistic children’s cognitive and language features has been greatly influenced by theoretical models and research approaches.
Multi-Spectral Imaging for Weed Identification in Herbicides Testing
Authors: López Luis O. , Ortega Gloria , Agüera-Vega Francisco , Carvajal-Ramírez Fernando , Martínez-Carricondo Patricio , Garzón Ester M.
Published: November 2022

A new methodology to help to improve the efficiency of herbicide assessment is explained. It consists of an automatic tool to quantify the percentage of weeds and plants of interest (sunflowers) that are present in a given area. Images of the crop field taken from Sequoia camera were used. Firstly, the quality of the images of each band is improved. Later, the resulting multi-spectral images are classified into several classes (soil, sunflower and weed) through a novel algorithm implemented in e-Cognition software. Obtained results of the proposed classifications have been compared with two deep learning-based segmentation methods (U-Net and FPN).
Zoning of radioactively contaminated territories after the Chornobyl accident
Authors:   Ukrainian Institute of Agricultural Radiology, National University of Life and Environmental Sciences of Ukraine, Kyiv, Ukraine, Kashparov V.O. , Holiaka D.M. , Levchuk S.E. , Berkovskyy V.B. ,   Center for Environmental Radioactivity (CERAD), Norwegian University of Life Sciences, Ås, Norway,   Ukrainian Radiation Protection Institute, Kyiv, Ukraine,   National Research Center for Radiation Medicine of the NAMS of Ukraine, Kyiv, Ukraine
Published: November 2022

The radiological zoning of Chornobyl contaminated areas was one of the essential elements of social and radiation protection. The zoning was based on estimates of annual committed effective doses to members of the public and on the levels of radionuclide deposition density. In 1991, 86 settlements were classified as associated with the zone of unconditional (mandatory) resettlement, and 841 settlements were assigned to the zone of guaranteed voluntary resettlement. The status of these settlements has been preserved until now. The assessments showed that as of 2022, for all settlements located outside the Chornobyl Exclusion Zone the radiological conditions do not exceed the current legislative criteria for inclusion in the zone of unconditional (mandatory) resettlement. It is also shown that in 2022, the zone of guaranteed voluntary resettlement can be assigned for: only 38 settlements, according to the legislative criterion "90Sr density of contamination" and only 17 settlements, according to the legislative criterion "137Cs density of contamination". The work also indicates and analyses the provisions of current legislation that require clarification.
Relações entre a saúde mental e a conjugalidade de gestantes primíparas
Authors: Oliveira João Marcos de , Alvarenga Patrícia , Soares Zelma Freitas
Published: November 2022

Este estudo avaliou as relações entre variáveis sociodemográficas, saúde mental da mulher e conjugalidade durante a gestação. Participaram desta pesquisa correlacional 50 mulheres primíparas, que coabitavam com o genitor do bebê e que estavam no segundo ou terceiro trimestre de gestação do primeiro filho. Os sintomas de transtornos mentais comuns foram avaliados pelo Self-Reporting Questionnaire (SRQ-20) e os sintomas depressivos pelo Inventário Beck de Depressão (BDI-I). A conjugalidade foi avaliada com a Escala de Ajustamento Diádico. Os resultados de testes de correlação e de comparação de grupos mostraram que a presença de sintomas de transtornos mentais comuns e de depressão esteve associada a menor nível de ajustamento diádico. Discute-se a importância de identificar problemas na saúde mental da mulher e no ajustamento diádico durante a gestação, para favorecer o bem-estar da tríade mãe-pai-bebê na transição para a parentalidade.
Development Of Maharah Qira'ah Evaluation Tool Using Moodle For Eighth Graders at MTs
Authors: Fadhilah Khairani , Rahmawati Rahmawati
Published: November 2022

Evaluation is the main component in the teaching and learning process, these components ‎are objectives, materials, methods, evaluation. The good evaluation standards are; inclusivity of evaluation; continuity of evaluation;  objectivity; differentiation, and variety. Evaluation in the teaching and learning process is very ‎important because it uses various and different tools in evaluating reading skills learning to ‎find out how far their progress in learning to read. Evaluation as a data collection tool has ‎many tools, and these tools are tests and non-tests. The test as an assessment tool has ‎various types. One type is a written test and one of the tools in Moodle. the problem statement is ‎evaluation of reading skills in MTs has not used an evaluation tool with Moodle, students ‎are less enthusiastic in evaluating reading skills, and teacher lacks mastery technology. The ‎problem statement in this study is how to develop a reading skill evaluation tool using ‎Moodle for eighth grade in MTs?. The research method used is research and development ‎with 4D models (define, design, develop, disseminate) but the author limits it to the third ‎stage that is development. The results of this study are: (1) needs analysis includes analysis of the ‎‎2013 education curriculum, student books and the forms of tests used, analysis of the needs ‎of Arabic teachers and students (they really need the development of this tool) (2) Designing ‎a reading skill evaluation tool using Moodle includes writing a grid of questions, writing test ‎questions, and making evaluation tools in Moodle (3) The results of developing a reading ‎skill evaluation tool using moodle for eighth grade in MTs include the validity of linguists ‎and evaluations and media, and the results of all of them show very good ratings and this ‎means it is possible to use Moodle in the evaluation without correction
Development Of Arabic Teaching Materials For Integrated Islamic Kindergartens Al-Irsyad Dharmasraya
Authors: Anggraini Riri
Published: November 2022

Education is a process of rebuilding experiences by which students acquire knowledge, skills, attitudes and values. In other words, it is the number of methods by which the elements of the environment around the learner are organized representing what is extended by the word environment in the sense of obtaining certain educational items. Teaching materials are one of the tools or teaching tools that contain materials, methods a`nd assessments that design educational materials to achieve educational goals. This research is a development research with 4D model which consists of four steps, namely; definition, design, development, and deployment. However, the researcher limits the development procedure in terms of assessing media based on experts in terms of  teching material, design, language. The development procedure in this research is; the development needs analysis stage, namely the analysis of the needs of Arabic teachers, and student books. The results of the data obtained show a rating of "Very Good" in the sense that the development of these teaching materials is very much needed. Then the planning stage starts from collecting teaching materials and then making teaching materials. After finishing making teaching material products, proceed to the development stage, namely; with expert leverage, product modification, product trial and final production. The results of the validation of teaching materials show a value of "Very Good" which means that teaching materials can be used in learning Arabic for integrated Islamic kindergartens.
OPTIMASI FUNGSI NONLINEAR TIGA VARIABLE MENGGUNAKAN ALGORITMA GENETIKA
Authors: Adri Didin
Published: November 2022

Pada penelitian ini akan ditentukan nilai minimum dari tiga buah fungsi yang berbeda menggunakan algortima genetika. Pengkodean algortima genetika pada penelitian ini menggunakan binary encoding. Metode crossover yang dipilih adalah uniform crossover dengan menggunakan parameter Jumlah Maksimum generasi (mIt) = 100; Jumlah Populasi (nPop) = 100; Probabilitas Crossover (pCro) = 0,01; Probabilitas Mutasi (pMut) = 0,02. Kemudian Program dijalankan sebanyak 20 kali untuk melihat konsistensi nilai yang dihasilkan dari kode program yang dibuat, kemudian diperoleh hasil sebagai berikut : Nilai minimum untuk fungsi pertama adalah  1,0000, nilai minimum dari fungsi kedua adalah 0 dan nilai minimum dari fungsi ketiga adalah 49,0000
PENDEKATAN MULTIVARIATE ADAPTIVE REGRESSION SPLINES UNTUK MEMODELKAN TINGKAT KEMISKINAN DI PROVINSI SUMATERA BARAT
Authors: Putra Romy Yunika , Roza Afnita , Putri Hesti Maria
Published: November 2022

Multivariate Adaptive Regression Splines (MARS) merupakan salah satu metode statistik yang menggunakan pendekatan regresi nonparametrik. Regresi nonparametrik digunakan apabila tidak terdapat informasi tentang bentuk fungsi dan tidak ada pola hubungan antara variabel dependen dengan variabel independen. Pada penelitian ini metode MARS diaplikasikan pada data tingkat kemiskinan di Provinsi Sumatera Barat. Unit observasi pada penelitian ini adalah 19 Kabupaten/Kota di Provinsi Sumatera Barat. Hasil penelitian menunjukkan bahwa model MARS terbaik adalah dengan menggunakan Basis Fungsi (BF) = 18, Maksimum Interaksi (MI) = 2, dan Minimum Observasi (MO) = 3 dengan GCV yang dihasilkan sebesar 0,001 dan nilai R2 sebesar 99,99%. Variabel independen yang memberikan kontribusi terhadap tingkat kemiskinan pada model terbaik secara berturut-turut adalah Tingkat Partisipasi Angkatan Kerja (X3) sebesar 100%, Jumlah Puskesmas (X5) sebesar 55,5%, Angka Harapan Hidup (X4) sebesar 45%, Rumah Tangga yang Menempati Rumah dengan Status Tidak Milik Sendiri (X6) sebesar 28,6%, dan Angka Partisipasi Sekolah (X1) sebesar 19,5%.Kata Kunci: Kemiskinan, MARS, Regresi Nonparametrik
ESTIMASI HARGA OPSI BELI TIPE EROPA MENGGUNAKAN EKSPANSI GRAM-CHARLIER PADA SAHAM LUAR NEGERI
Authors: Agustina Dina , Zulfa Femilya Sri
Published: November 2022

Model Black-Scholes merupakan salah satu model untuk menentukan harga opsi tipe Eropa dengan asumsi return dari saham harus berdistribusi normal. Pada kenyataannya return saham tidak mengikuti bentuk distribusi normal, dimana artinya skewness dan kurtosis saham tidak sama dengan 0 dan 3. Untuk mengatasi ketidaknormalan dari return saham dilakukan modifikasi model Black-Scholes dengan ekspansi Gram-Charlier dengan pendekatan polynomial untuk mengatasi bentuk data yang tidak berdistribusi normal. Harga opsi dengan ekspansi Gram-Charlier dipengaruhi oleh beberapa faktor yakni harga saham awal (), harga kontrak (), tingkat suku bunga bebas risiko (), waktu jatuh tempo (), volatilitas ( ), skewness dan kurtosis. Hasil dari studi menunjukkan bahwa dengan penentuan harga opsi dengan menggunakan metode Gram-Charlier sedikit lebih mendekati harga pasar dari pada menggunakan model Black-Scholes.Kata Kunci: Call option, Black-Scholes, Ekspansi Gram-Charlier, polinomial Hermite, kurtosis
EFFECT OF TEAMWORK ON SURVIVAL OF MANUFACTURING SMALL AND MEDIUM ENTERPRISES IN NIGERIA
Authors:   University of KwaZulu-Natal, South Africa, Nwankwo Cosmas Anayochukwu , Kanyangale MacDonald Isaac ,   University of KwaZulu-Natal, South Africa
Published: November 2022

In many industries, teamwork is critical to enterprise existence. However, many manufacturing small and medium firms (SMEs) in Nigeria have failed to survive before their fifth birthday. The aim of this positivistic study is to examine the effect of teamwork on the survival of manufacturing SMEs in Nigeria. A structured questionnaire is used to collect data from 364 owner-managers of manufacturing SMEs selected using stratified random sampling technique. Structural equation modeling (SEM) is used to analyze data. Results show that teamwork has a strong, positive, and significant effect on the survival of manufacturing SMEs in Nigeria. More specifically, the dimension of communication is a strong predictor of SME's survival, followed by recognition, team spirit, and collaboration. The study concludes that there is a variety of critical dimensions of teamwork for the survival of manufacturing SMEs. The study also recommends that if manufacturing SMEs are to survive and thrive in Nigeria, owner-managers must demonstrate and promote a multi-dimensional and nuanced vision of teamwork. The study's findings have key pragmatic and research implications.
PRE-COVID MORTALITY IN NORTH OSSETIA-ALANIA
Authors:   Georgia Southern University, USA, Brock Gregory
Published: November 2022

North Ossetia-Alania (NOA) regional mortality over thirty years of transition is described in detail for the first time. Though NOA and other Caucasus regions are perceived to have higher life expectancy than Russia overall, we find that, like the rest of Russia, men live much shorter lives in both rural and urban areas. Urban mortality is lower for most causes of death than rural mortality with women in particular showing improvements in lowering mortality and higher life expectancy at birth. Male mortality across all ages is better in the 21st century than the 1990s but has not improved recently relative to the early 2000s. Sigma and beta mortality divergence reveal little improvement in male mortality relative to female mortality with the gender gap unchanged since the Soviet era which is unusual at the regional level. Nostalgia for Soviet era health systems is misplaced as health has improved since then especially like other regions in the area of infant mortality and deaths before the age of 5. Policy recommendations include moving some health care out of the capital of Vladikavkaz to take advantage of relatively lower rural mortality as well as promoting more rural economic development.
Effect of systemic isotretinoin use on neutrophil/lymphocyte ratio in acne patients: A retrospective study
Authors: AKÇA Hanife Merve
Published: November 2022

Objective: Acne vulgaris (AV) describes a chronic inflammatory condition that occurs in the pilosebaceous unit, which is common in the community. Increase in sebum production, abnormal follicular keratinization, Propionibacterium acnes (P.acnes) colonization and inflammation play a role in acne development. ISO, comedolytic, is the only agent that has an effect on all four conditions that determine the pathogenesis of acne, such as a large reduction in sebaceous gland size, suppression of sebum production and reduction in inflammation. In this study, it was aimed to compare the N/L ratio values at the beginning of the treatment and at the 4th month of the treatment in acne vulgaris patients receiving systemic ISO treatment. Material and Method 50 patients with acne vulgaris who applied to the dermatology outpatient clinics of Karaman Training and Research Hospital between October 2020 and February 2021, had moderate and severe acne vulgaris and were started on oral isotretinoin were included in the study. The medical records of the patients were reviewed retrospectively. The neutrophil/lymphocyte (N/L) ratio values of the patients at the beginning of Isotretinoin treatment and after four months were recorded. Results The mean age of the patients was 23.1±6.23, 52.0% (26 persons) were male. There was a significant decrease in the N/L ratio in total and in both genders with isotretinoin use (p
Comparison Of Winograde And Vandenbos Surgical Techniques According To Heifetz Stage In The Treatment Of Ingrown Toenails
Authors: KAYA Emre , COŞKUN Tamer
Published: November 2022

Abstract

Background: In ingrown toenail, classifications and the treatment approaches according to staging has been clearly reported in the literature. However, there are not enough data about the selection of the appropriate surgical technique according to the stage. In this study, we compared two different surgical techniques in patients with Heifetz stage 2 and 3 in means of surgical results, recovery time, patient comfort and cosmetics.

Methods: Between January 2019 and January 21, patients who applied with the complaint of ingrown toenails who were treated with two mentioned surgical techniques in two centers with at least 1 year follow-up were included. The patients were evaluated preoperatively in means of the Heifetz classification. In group 1 (n:54) matrix excising Winograd and in group 2 (n:51) matrix preserving Vandenbos techniques were used. Postoperative recovery time, complication rates, functional and cosmetic patient satisfaction were evaluated in tall cases.

Results: 105 cases of ingrown toenails treated surgically were included in the study. 62 (59%) cases were Heifetz stage 2, 43 (41%) cases were Heifetz stage 3. No statistically significant difference was found between Heifetz stage 2 and stage 3, regardless of surgical technique, in complication, recurrence, patient functional/cosmetic satisfaction rates, and recovery time. In overall analysis regardless of Heifetz staging, recovery time was shorter with Winograd method (p:0.0001), complication and recurrence rates were lower with Vandenbos method (p:0.0001), and VAS cosmetic satisfaction was higher in Vandenbos (p:0.002).

Conclusion: Winograd and Vandenbos in Heifitz stages 2 and 3 have low complication rates and high patient satisfaction. Earlier healing could be achieved with the Winograd technique, while low complication/recurrence rates and high cosmetic satisfaction could be achieved with the Vandenbos technique. Early recovery/high cosmetic expectation should be considered instead of Heifetz staging in determining the surgical technique.
Retrospective Analysis of Oral and Maxillofacial Pathologies
Authors: HAYLAZ Emre , ŞEKER Çiğdem , GEDUK Gediz , İÇEN Murat , GÜLŞEN Elif Aslı
Published: November 2022

Objectives: The aim of this study is to analyze the biopsy results of oral and maxillofacial lesions and to discuss them in the accompanied by the literature. Material and Method: In the study, biopsy results of 644 patients who were admitted to Zonguldak Bülent Ecevit University Faculty of Dentistry, Department of Oral and Maxillofacial Radiology between 2016-2021 for various reasons and subsequently diagnosed with oral and maxillofacial pathology were retrospectively analyzed using digital archives. Age, gender, location of the lesions and pathological diagnoses of the patients were recorded. Results: In the study, 344 (53,41%) of the patients whose biopsy reports were examined were male and 300 (46,59%) were female, and the male: female (M: F) ratio was determined to be 1,15:1. The age range varied between 7 and 88 years and the mean age was 37,85±17,35 years. Out of a total of 644 lesions, 436 (67,8%) were cysts, 148 (23,1%) were inflammatory/reactive lesions, 57 (9,3%) were benign tumors and tumor-like lesions, and 3 (0,5%) were included in the malignant tumor and tumor-like lesion group. Conclusions: The analysis of data on oral and maxillofacial lesions is of great importance for the planning of preventive and therapeutic services. Amaç: Bu çalışmanın amacı, oral ve maksillofasiyal lezyonların biyopsi sonuçlarını analiz etmek ve literatür eşliğinde tartışmaktır. Gereç ve Yöntem: Çalışmada, 2016-2021 yılları arasında Zonguldak Bülent Ecevit Üniversitesi Diş Hekimliği Fakültesi Ağız, Diş ve Çene Radyolojisi Anabilim Dalı'na çeşitli nedenlerle başvuran ve sonrasında oral ve maksillofasiyal patoloji tanısı alan 644 hastanın biyopsi sonuçları dijital arşiv kullanılarak retrospektif olarak incelenmiştir. Hastaların yaşları, cinsiyetleri, lezyonların lokalizsyonları ve patolojik tanıları kaydedildi. Bulgular: Çalışmada, biyopsi raporu incelenen hastaların 344'ü (%53,41) erkek, 300'ü (%46,59) kadın olup, erkek:kadın (E:K) oranı 1,15 :bir olarak belirlendi. Yaş aralığı 7 ile 88 arasında değişmekte olup, yaş ortalaması 37,85±17,35 yıl idi. Toplam 644 lezyonun 436'sı (%67,8) kist, 148'i (%23,1) inflamatuar/reaktif lezyonlar, 57'si (%9,3) iyi huylu tümörler ve tümör benzeri lezyonlardı ve geriye kalan 3 (% 0,5) patoloji malign tümör ve tümör benzeri lezyon grubundaydı. Sonuç: Oral ve maksillofasiyal lezyonlara ilişkin verilerin analizi, koruyucu ve tedavi edici hizmetlerin planlanması için büyük önem taşımaktadır.
Study on the Impact of Fresh Food E-Commerce Logistics Service Quality on Customer Satisfaction, Customer Trust, and Repurchase Intention
Authors:   The Korea International Trade Research Institute, Zhou Huizhuo , Xing Xiaoyu
Published: November 2022

Purpose - This study is meaningful in providing strategic implications for improving the logistics service quality of fresh food e-commerce companies by empirically analyzing the impact of logistics service quality on customer satisfaction, customer trust, and repurchase intention.
Design/Methodology/Approach - The study collected data on 285 customers with shopping experience on fresh food e-commerce platforms and verified with a structural equation model using AMOS 26.0.
Findings - First, it was confirmed that the delivery quality, timeliness, and reliability of fresh food e-commerce logistics service quality had a positive impact on customer satisfaction. Second, it was found that delivery quality, information quality, and reliability of fresh food e-commerce logistics service quality had a positive impact on customer trust. Third, both customer satisfaction and customer trust had a positive impact on repurchase intention.
Research Implications - In terms of theory, theoretical research is carried out by investigating which factors of fresh food e-commerce logistics service quality can improve customer satisfaction and customer trust. In terms of practice, it provides reference suggestions for fresh food e-commerce enterprises to improve the quality of logistics services and improve business performance in the future. It will also provide a reference for other follow-up research.
Vehicle Currency Pricing and the Effect of Exchange Rates on Export and Import Prices
Authors:   The Korea International Trade Research Institute, Chiang Bong-Gyu
Published: November 2022

Purpose - Since most of Korea's import/export transactions are made using US dollars as the invoicing currency, it is necessary to consider not only the won/dollar exchange rate but also the exchange rate between the dollar and the import/export currency when examining the effect of exchange rates on import/export prices.
Design/Methodology/Approach - This essay theoretically examined that in the vehicle currency trades, the prices in vehicle currency are affected not only by the exchange rate between the exporting country currency and the vehicle currency but also by the exchange rate between the vehicle currency and the importing country currency. This was confirmed by empirical analysis in Korea's imports and exports.
Findings - In exports by country, the coefficient of the won/dollar exchange rate showed a significant value in 11 out of 21 countries, and the effect of the dollar/importing country currency exchange rate was significant in 13 out of 21 countries. In imports by country, the dollar/exporting currency exchange rates showed significant effects in 10 out of 21 countries, and the effect of the won/dollar exchange rate was significant in 8 countries.
Research Implications - When studying the effect of exchange rates on import/export prices in the case of vehicle currency pricing, not only the effects of the exchange rate between the importing/exporting country currencies but also the effects of various exchange rates should be considered according to the invoicing currency.
What Factors Influence the Churn Intention in the Context of Online Learning Platform
Authors:   The Korea International Trade Research Institute, YAN Jinzhe , Zhao Zhao , Kim Yeonggil
Published: November 2022

Purpose - With the rapid development of Internet technology, the large-scale popularization of intelligent terminals, and the influx of users into online learning platforms caused by COVID-19, online education has become a new outlet for the internet. However, with the control of COVID-19, online learning platforms face problems of low user stickiness and severe loss. Therefore, it is necessary to discuss the factors that affect users’ willingness to pay for online learning platforms.
Design/Methodology/Approach - Using Unified Theory of Acceptance and Use of Technology and Regulatory Focus theory, this study constructed the influencing factor model of paying user turnover intention of online learning platform. This study collected 332 valid sample data through a questionnaire survey, and tested the main effect and moderating effect by adopting regression analysis. This study explored the factors affecting the churn intention of paying users of online learning platforms and the influence degree of each factor, and explored the influencing factors of the churn intention of paying users on online learning platforms from multiple angles.
Findings - The results identified that the influencing factor model of user turnover intention constructed in this paper is practical, seven hypotheses are tenable, and three hypotheses are partially supported. Finally, based on the above research conclusions, this study puts forward strategies to reduce the churn intention of paying users on online learning platforms on three aspects: user segmentation, continuous use process, and influencing factors of online learning platform users, to provide some reference value for online learning platform operators and designers.
Research Implications - Based on the previous analysis results, this study puts forward corresponding improvement strategies from three aspects: user segmentation, continuous use process, and influencing factors in order to provide a specific reference value for reducing the churn of paying users’ online learning platforms.
Biodentine stimulates the migratory and biological responses of human gingival fibroblast
Authors:   Laboratory of Tissue Bioengineering. Postgraduate Studies Division. Faculty of Dentistry. UNAM, Ciudad Universitaria 3000, Col. Copilco Universidad, Coyoacán. 04360. CDMX, Mexico., Vázquez-Vázquez Febe , Rodríguez-Hidalgo Alejandra ,   Dept of Endodontics. Postgraduate Studies Division. Faculty of Dentistry. UNAM, Ciudad Universitaria 3000, Col. Copilco Universidad, Coyoacán. 04360. CDMX, Mexico., Suaste-Olmos Fernando ,   Dept of Molecular Biology and Biotech-nology. Institute of Biomedical Research and Institute of Cellular Physiology. UNAM, Ciudad Universitaria s/n, 04510. CDMX, Mexico., González-Alva Patricia ,   Laboratory of Tissue Bioengineering. Postgraduate Studies Division. Faculty of Dentistry. UNAM, Ciudad Universitaria 3000, Col. Copilco Universidad, Coyoacán. 04360. CDMX, Mexico., Alvarez-Perez Marco ,   Laboratory of Tissue Bioengineering. Postgraduate Studies Division. Faculty of Dentistry. UNAM, Ciudad Universitaria 3000, Col. Copilco Universidad, Coyoacán. 04360. CDMX, Mexico.
Published: November 2022

Introduction: Biodentine (BD), a dentin substitute, is currently used to treat external cervical root resorption, but its effects on gingival fibroblasts (GFs) are not fully known. Objective: To investigate and compare BD and MTA (mineral trioxide aggre-gate) in terms of proliferative, migratory, and adhesion effects on human pulpal and gingival cells. Material and Methods: Cells were incubated directly on the surface of BD and MTA disks. Adhesion (4 and 24 h) and proliferation (3, 5, 7, 14, 21) were evaluated with crystal violet and MTT assays (n=9 X each group). A wound-healing assay was performed for cell migration, with 0.2 and 2 µg/ml MTA or BD (n=6 X each group). The cut-off point for statistical significance was set at p<0.05, p<0.01 and p<0.001. Results: The best adhesion and proliferation results for gingival fibroblast (GFs) were obtained with BD (p<0.01). MTA and BD enhanced the migration of GFs in a dose-dependent manner, with superior results with BD, and 2 µg/ml was the optimal concentration for enhancing the migration of GFs. Conclusion: Results indicate that BD and MTA exhibit excellent compatibility in terms of cell adhesion, proliferation, and cellular migration. Also, the results suggested that BD is associated with better results than MTA in GFs. The results support the clinical application of BD in areas colonized with GFs.
Javítóintézeti nevelők metaforákban tükröződő intézményképe
Authors: Izsák Hajnalka
Published: November 2022

The juvenile detention center or reformatory is a specific world that operates simultaneously as a penal and a pedagogical institution. On the one hand, as part of the child protection system, it has an educational function, on the other hand, correctional education is a judicial measure applicable to juvenile offenders in the case of a criminal offense. The aim of the present study is to provide through correctional educators’ metaphors an insight into how educators relateto their workplace and the way they experience working in a closed institution. The metaphors used by correctional educators outline the specifics of the institution in a typical way; in addition, we can also obtain a large amount of information about the educational work carried out in the institution.