bluuebunny/crossref_metadata_2025 huggingface dataset:
In silico Identification of Potential Small Molecules Targeting Six Proteins in Nipah Virus using Molecular Docking, Pharmacophore and Molecular Dynamics Simulation
Authors: Joy Amitha , John Arun , Padman Midhila , Praveena P.
Published: June 2022

Introduction:

Nipah virus (NiV) is a highly pathogenic zoonotic virus of the genus Henipavirus, which causes severe respiratory illness and deadly encephalitis with a fatality rate of 50%-70 % in humans. A total of 16 NiV proteins are available in the Protein Data Bank (PDB) of which six proteins belong to the structural class.

Method:

In this study, a cluster of six proteins of classes Viral attachment glycoproteins (2VWD, 2VSM), Fusion glycoprotein (5EVM, 6PD4), Matrix protein (6BK6), and Phosphoprotein (4HEO) were considered as potential therapeutic targets. Here, 25 small molecule inhibitors were chosen which include 23 natural compounds with antiviral properties and 2 antiviral drug molecules as control. The potential inhibitors among the selected compounds were identified based on docking score, significant intermolecular interactions, ADME (absorption, distribution, metabolism, and excretion) properties, pharmacophore and toxicity studies. Moreover, 100 nanoseconds molecular dynamics simulation was carried out for the best selected compound with all protein targets to understand the stability and binding strength.

Result and Discussion:

In this study, we propose that the baicalin was found to be the most potential lead molecule with higher binding affinity, strong bonded interactions, favorable pharmacophore features and higher complex stability.

Conclusion:

Hence, the compound identified shall prove effective against the Nipah virus targeting the viral attachment glycoprotein.
Patient Satisfaction regarding Conventional One-Piece Versus Two-Piece Magnet-Retained Obturator for Patients with Complete Edentulism: A Preliminary Crossover Clinical Trial
Authors: Sharaf Mohamed Yahia , Eskander Asharaf Email
Published: June 2022

Purpose:

This study aimed at evaluating patients' satisfaction with conventional one-piece obturators versus two-piece magnet-retained obturators in completely edentulous patient maxillectomy cases.

Materials and Methods:

Ten completely edentulous participants with hemimaxillectomy (8 males and 2 females) were selected in a crossover study. Participants received a conventional obturator one-piece and two-piece obturators connected by magnet attachment in alternate periods (sequences A‐B and B‐A), and outcomes were assessed after 1 week, 3 months, and 6 months Evaluation was made using Obturator Functioning Scale (OFS) and Oral Health Impact Profile for edentulous people (OHIP-EDENT). One way ANOVA test and multivariate analysis of variance with a general linear model with repeated measures was used to test the impact of the group, time, and order on each of the studied scores (α=.05).

Results:

Magnet design showed a statistically significant lower score (P<.050) than the conventional design regarding the overall satisfaction score of OFS along all follow-up periods. Concerning OHIP-EDENT, the magnet design showed a statistically significant lower score (P<.050) than the conventional design regarding total functional limitations, total physical pain, and total social disability along all follow-up periods while for total psychological discomfort, total physical disability, and total handicap, no statistically significant difference was observed between both groups (P>.050).

Conclusion:

Two-pieces magnet-retained obturator could provide better satisfaction and better restoration of orofacial function than the conventional one to manage completely edentulous patients.

Clinical Trial Registration Number:

NCT05066828
Atatürk Üniversitesi Eğitim Aile Sağlığı Merkezlerine Kayıtlı Hastalarda Diyabetik Retinopati Sıklığı, İlişkili Faktörler ve Diyabetik Retinopati Farkındalığı: Kesitsel Bir Çalışma
Authors: YILDIRIM Yeşim , ÇAYIR Yasemin , YILDIRIM Gökhan
Published: June 2022

Amaç: Çalışmamızda Tip 2 diyabet hastalarımızda diyabetik retinopati (DRP) sıklığını, ilişkili faktörleri ve DRP farkındalık düzeyini değerlendirmeyi amaçladık. Gereç ve Yöntem: Çalışma Şubat 2019-Nisan 2020 tarihleri arasında Atatürk Üniversitesi Tıp Fakültesine bağlı Eğitim Aile Sağlığı merkezlerinde (EASM) yürütülmüştür. Kayıtlı 350 diyabet hastasına telefonla ulaşılıp çalışma hakkında bilgi verilerek çalışmaya davet edildi. Yapılan örneklem hesabına göre 18 yaş üstü Tip 2 diyabet tanısı almış 200 hasta çalışmaya dahil edildi. Tip 1 DM olanlar, oftalmolojik cerrahi geçirenler çalışmaya dahil edilmedi. Yüz yüze görüşme ile hastaların sosyodemografik ve klinik özellikleri kaydedilip; DRP farkındalık anketi uygulandı. Hastalar ikinci basamak sağlık kuruluşuna yönlendirildi ve bir göz hekimi tarafından detaylı oftalmalojik muayeneleri yapıldı. Veriler SPSS 20.0.0 ile analiz edildi. Anlamlılık düzeyi p<0,05 kabul edildi. Bulgular: Katılımcıların yaş ortalamaları 56,8±9,9 yıldı, %45,5’i (n=91) kadındı. Hastaların %36’sında (n=48) DRP tespit edildi. DRP’si olanların %60,4’ünde (n=29) mikrohemoraji mevcuttu. Sigara kullananlarda, ileri yaşta, DM tanı süresi fazla, HbA1c ortalaması ve sistolik kan basıncı ortalaması yüksek olanlarda DRP sıklığı daha fazlaydı (p<0,05). Bu değişkenler içinde DM tanı süresi, HbA1c düzeyi ve sigara kullanımı DRP olasılığını tahmin ettiren en önemli değişkenler olarak tespit edildi. 'Şeker hastaları ne sıklıkla göz muayenesi olmalıdır?' sorusuna %33,5 (n=37) oranında yılda bir kez cevabı verilmişti. Katılımcıların %58,5’i (n=117) en son göz muayenesine bir yıldan daha uzun zaman önce giderken; %6,5’i (n=13) hiç göz muayenesi olmamıştı. Bir hekim tarafından göz muayenesi önerilenlerin %20'sine (n=14) aile hekimi tarafından öneri yapılmıştı. Sonuç: Araştırma popülasyonunda DRP oranı yüksek olup; sigara kullananlarda, ileri yaşta, uzun süredir DM olanlarda, HbA1c ve sistolik kan basıncı yüksek olanlarda bu oran daha fazlaydı. Hastalarımızın DRP hakkında bilgi ve farkındalığı yetersizdi. Birinci basamak sağlık hizmeti sunan ve koruyucu hekimlik için kilit noktada bulunan aile hekimlerinin bu konudaki rolü önemlidir. Diyabetik hastalarda DRP gelişimini önlemek için aile hekimleri tarafından verilecek sigara bırakma danışmanlığı ve yakın takiplerle kan şekeri ve kan basıncı regülasyonunun sağlanması oldukça önemlidir.
The Effect of Physical Activity on Mental Health in Adults During Covid-19 Pandemic
Authors: SELÇUK TOSUN Alime , LÖK Neslihan , BADEMLİ Kerime , LÖK Sefa
Published: June 2022

Introduction: The COVID-19 pandemic profoundly affected the life of individuals. The purpose of this study was to determine the physical activity and mental health levels of people who had to stay home during the COVID-19 outbreak, and to examine the correlation between physical activity and mental health levels. Methods: A descriptive correlational study design was used in this study. The study sample consisted of 180 participants. The data collection form was consisted of 'The Personal Information Form', 'General Health Questionnaire (GHQ-12)' and 'Physical Activity Questionnaire (IPAQ)'. In the analysis of datas were used descriptive statistics, chi-square, mann whitney U test, one way anova, independent sample t-test and pearson correlation analysis. Results: The results have shown that in COVID-19 pandemic, the majority of participants were physically inactive, and especially in women. A negative significant correlation was found between the physical activity level and GHQ-12 score of the participants (r = -0.872, p = 0.0001). Conclusion: Majority of participants' physical activity level was negatively affected in the COVID-19 pandemic.
HERNİYASYON İLE PREZENTE BACİLLUS CALMETTE-GUERİN (BCG) AŞISIZ PEDİATRİK TÜBERKÜLOZ MENİNGOENSEFALİT OLGUSU
Authors: ALMAK Deniz , ŞEN Semra , BAYSAL Neslihan , LÜLECİ Duygu
Published: June 2022

Tüberküloz günümüzde halen belli başlı ölüm sebeplerinden bir tanesidir. Yüksek aşılama oranları ile tüberküloz meningoensefalit vakaları belirgin azalmış olmakla birlikte, göç gibi sosyal problemler nedeniyle bu klinik tablonun halen görülebileceğine sunduğumuz bu olgu ile dikkat çekilmek istenmiştir. Tüberküloz menenjitin hızla tanısı ve tedavisinin önemi vurgulanmak istenmiştir. Özellikle mülteciler gibi düşük gelirli ve sağlık güvencesi olmayan gruplarda, aşıyla önlenebilir hastalıkların ve komplikasyonlarının akılda tutulması önemlidir.
Comparision of Illness Perceptions of Individuals With and Without Colorectal Cancer in Their First-Degree Relatives
Authors: BÖLÜKBAŞI Hande , DÖNER GÜNER Pınar
Published: June 2022

Aim: This study aimed to evaluate and compare the knowledge and attitudes of relatives of patients with colorectal cancer and those who do not have colorectal cancer. Methods: The study was conducted with the relatives of colorectal cancer patients who applied to the Oncology outpatient clinic and the patients who did not have colorectal cancer in the family who applied to the Family Medicine outpatient clinic. In the data collection, the questionnaire prepared by the researcher to determine the personal characteristics of the individuals participating in the study and the 'Health Belief Model Scale for Colorectal Cancer Prevention' to determine the health beliefs were used. Results: The mean age of the 120 participants was 36.59 ± 12.7 years, 55.8% (n = 67), women, 65.8% (n=79) is married and 69.2% (n=83) live in the city. Colorectal cancer screening rate was significantly higher in the case group (p=0.004). The most frequently reported barriers to get colorectal cancer screening tests were not knowing colorectal cancer and screening tests (38.3%). The confidence benefit perception score average of the control group was significantly higher than the average score of the case group (p = 0.018). Conclusion: In our study, the level of the perception of trust and benefit was lower in the patients whose first-degree relatives had CRC compared to those who had not in their family. Although the expectation of early diagnosis, using CRC screening, was higher in the patients with CRC in their first-degree relatives, there was no significant difference between the two groups. This fact reveals the necessity of evaluating the risks for the individuals while providing counseling to them for colorectal cancer screening as well as updating the training.
Are anti-vaxxers threatening physicians? A Belgian perspective
Authors: Fastenaekels Jeroen , Steyaert Aurelia , De Cauwer Harald , Mortelmans Luc , Somville Francis
Published: June 2022

The COVID-19 pandemic showed how anti-government, anti-science and anti-vaxxer rhetoric collide in an international movement against vaccination and lockdown measures. We assessed if Belgian physicians were threatened by anti-vaxxers using an online survey. We assessed what the impact was on their clinical activities and how they coped with anti-vaxxer rhetoric. N=283 physicians completed the survey. Since the COVID-19 pandemic started 11% of the respondents received threats from anti-vaxxers. Threats were distributed via social media (55%), personal email (35%), personal letter (16%), and a posted flyer (39%). Physicians that got media attention were four times more likely to be threatened. We conclude that a substantial proportion of physicians were threatened by anti-vaxxers. The impact of anti-vaxxer rhetoric on clinical practice is various: some physicians feel angry, others are tired, while some even are scared. Another group of physicians is still combative in convincing anti-vaxxers.
STRENGTHENING HISTORICAL THINKING SKILLS THROUGH TRANSCRIPT BASED LESSON ANALYSES MODEL IN THE LESSON OF HISTORY
Authors: Abbas Ersis Warmansyah , Syaharuddin Syaharuddin , Mutiani Mutiani , Susanto Heri , Jumriani Jumriani
Published: June 2022

Strengthening historical thinking skills is needed in History subjects. This skill is eductive so that students can describe the chronology of events based on historical facts. Observations on subjects are needed to improve historical thinking skills, namely by implementing lesson study (ls) activities. This article aims to describe the strengthening of historical thinking in history learning through the LS activity of the Transcript Based Lesson Analysis (TBLA) model. The approach through the descriptive method is used in research. Three stages of data collection, namely; observation, interview, and documentation. Miles and Huberman's model is used for analyzing the saturation of the data obtained. Results describe students can demonstrate historical thinking skills by providing arguments during group discussions. The arguments are given to put forward the causal relationship (causality) in the sub-discussion ABRI's dual function. Transcript analysis of overall learning activities illustrates that there is a balance of conversation between teachers and students. This is because the learning conditions are conducive and teachers have no difficulty in increasing the participation of studentsKeywords; historical thinking, TBLA, and History learning
Abstrakcja malarska a abstrakcja muzyczna w dziełach Wasyla Kandyńskiego i Arnolda Schönberga
Authors: Chmielewska Aleksandra
Published: June 2022

The article describes the birth of new tendencies in painting and music as responses to the spiritual crises which ruled upon entering the twentieth century. The starting points for the discussion are chosen works by Wassily Kandinsky and Arnold Schonberg, as well as the theoretical treatise Concerning the Spiritual in Art by Kandinsky. The article presents similarities and various relations between artistic works of the two friendly artists.
Oratorium Chrystus na Górze Oliwnej opus 85 Ludwiga van Beethovena a estetyka Friedricha von Schillera
Authors: Grajter Małgorzata
Published: June 2022

Beethoven’s only oratorio, Christ on the Mount of Olives, Op. 85, was created in the phase marked by the strong influence of the thought of Immanuel Kant and the Weimar classics (in particular Goethe and Schiller), described as the climactic phase of Classicism. The musical activity of this phase is a response to the Enlightenment concept of man as a sensual-spiritual being. It gains the power of not only aesthetic but also ethical impact on the recipient. Beethoven, as a creator aware of his mission to create music, which was to raise an individual towards the ideals of humanity, was particularly influenced by Schiller’s philosophical and aesthetic thought: the influence of the great philosopher was by no means limited to the Ninth Symphony. Concerning Beethoven’s oratorio, this influence is particularly noticeable in the way the figure of Christ in the Garden of Gethsemane is depicted – both as a divine being and as a suffering, lonely man facing torment and death. Therefore, the aim of this article is to present Beethoven’s work in the context of the aesthetic writings of Friedrich von Schiller, with particular emphasis on the categories of beauty, sublime and pathetic.
Refleksje Henryka Mikołaja Góreckiego wokół tekstów Michała Hellera
Authors: Sołtysik Michał S.
Published: June 2022

Henryk Mikołaj Górecki (1933–2010) in many of his statements mentioned various philosophers or quoted their words, and other philosophical inspirations have been noted by researchers of his life. However, no separate discussion of this kind of inspiration has so far been written in relation to the author of the „Copernican” Symphony and Michał Heller (b. 1936). The present article is therefore an attempt to fill this lack in the scope of inspiration of the thought of this Cracovian philosopher. His selected texts are presented in relation to Górecki’s reflections on the basis of the composer’s statements and comments. The text is divided into three complementary parts: the first one is devoted to the beginnings of Górecki’s fascination with themes taken up in Heller’s works, the second one is a juxtaposition of the composer’s statements with musical and philosophical threads of the described thinker, and the third one presents Heller’s texts chosen by Górecki for the speech delivered during the ceremony of awarding the composer with an honoris causa doctorate of the Academy of Music in Cracow. From Górecki’s speeches and readings discussed in this article a wide range of themes which interested the composer in Heller’s texts can be seen. The most important and most frequently quoted by the author of the „Copernican” Symphony are those fragments in which the Cracovian philosopher pointed to analogies between music and the beauty of the symphonic ontology of the cosmos. Górecki did not stop at presenting these themes but also referred to Heller’s thoughts on other issues connected with philosophy and existential questions.
Muzyka jako droga i doświadczenie. Fenomenologiczne ścieżki badań nad doświadczeniem muzycznym
Authors: Szyszkowska Małgorzata A.
Published: June 2022

What is the phenomenology of music and how one distinguishes it from all other domains of studying music is the silent question that drives this text. The author assumes that the answer lies in pondering different ways of describing and analyzing music that is circular and continuous, based on experience and close, personal examination. Those elements, as the author suggests, are the most telling for recognizing the phenomenological studies on music. The author explores pathways to the experience of music as well as pathways into an understanding of music presenting certain examples of meandering ways of philosophying on music. Roman Ingarden, Maurice Merleau-Ponty, Jean-Francois, Arnold Berleant’s writings on music are mentioned to provide examples of very different and yet quite possibly deeply experiential ways of providing an understanding of music.
Effectiveness of a Diabetes-Focused Electronic Discharge Order Set and Postdischarge Nursing Support Among Poorly Controlled Hospitalized Patients: Randomized Controlled Trial
Authors: White Audrey , Bradley David , Buschur Elizabeth , Harris Cara , LaFleur Jacob , Pennell Michael , Soliman Adam , Wyne Kathleen , Dungan Kathleen
Published: June 2022

Background

Although the use of electronic order sets has become standard practice for inpatient diabetes management, there is limited decision support at discharge.

Objective

In this study, we assessed whether an electronic discharge order set (DOS) plus nurse follow-up calls improve discharge orders and postdischarge outcomes among hospitalized patients with type 2 diabetes mellitus.

Methods

This was a randomized, open-label, single center study that compared an electronic DOS and nurse phone calls to enhanced standard care (ESC) in hospitalized insulin-requiring patients with type 2 diabetes mellitus. The primary outcome was change in glycated hemoglobin (HbA1c) level at 24 weeks after discharge. The secondary outcomes included the completeness and accuracy of discharge prescriptions related to diabetes.

Results

This study was stopped early because of feasibility concerns related to the long-term follow-up. However, 158 participants were enrolled (DOS: n=82; ESC: n=76), of whom 155 had discharge data. The DOS group had a greater frequency of prescriptions for bolus insulin (78% vs 44%; P=.01), needles or syringes (95% vs 63%; P=.03), and glucometers (86% vs 36%; P<.001). The clarity of the orders was similar. HbA1c data were available for 54 participants in each arm at 12 weeks and for 44 and 45 participants in the DOS and ESC arms, respectively, at 24 weeks. The unadjusted difference in change in HbA1c level (DOS – ESC) was −0.6% (SD 0.4%; P=.18) at 12 weeks and −1.1% (SD 0.4%; P=.01) at 24 weeks. The adjusted difference in change in HbA1c level was −0.5% (SD 0.4%; P=.20) at 12 weeks and −0.7% (SD 0.4%; P=.09) at 24 weeks. The achievement of the individualized HbA1c target was greater in the DOS group at 12 weeks but not at 24 weeks.

Conclusions

An intervention that included a DOS plus a postdischarge nurse phone call resulted in more complete discharge prescriptions. The assessment of postdischarge outcomes was limited, owing to the loss of the long-term follow-up, but it suggested a possible benefit in glucose control.

Trial Registration

ClinicalTrials.gov NCT03455985; https://clinicaltrials.gov/ct2/show/NCT03455985
Correction: Age- and Sex-Specific Differences in Multimorbidity Patterns and Temporal Trends on Assessing Hospital Discharge Records in Southwest China: Network-Based Study (Preprint)
Authors: Wang Liya , Qiu Hang , Luo Li , Zhou Li
Published: June 2022

BACKGROUND

Multimorbidity represents a global health challenge, which requires a more global understanding of multimorbidity patterns and trends. However, the majority of studies completed to date have often relied on self-reported conditions, and a simultaneous assessment of the entire spectrum of chronic disease co-occurrence, especially in developing regions, has not yet been performed.

OBJECTIVE

We attempted to provide a multidimensional approach to understand the full spectrum of chronic disease co-occurrence among general inpatients in southwest China, in order to investigate multimorbidity patterns and temporal trends, and assess their age and sex differences.

METHODS

We conducted a retrospective cohort analysis based on 8.8 million hospital discharge records of about 5.0 million individuals of all ages from 2015 to 2019 in a megacity in southwest China. We examined all chronic diagnoses using the ICD-10 (International Classification of Diseases, 10th revision) codes at 3 digits and focused on chronic diseases with ≥1% prevalence for each of the age and sex strata, which resulted in a total of 149 and 145 chronic diseases in males and females, respectively. We constructed multimorbidity networks in the general population based on sex and age, and used the cosine index to measure the co-occurrence of chronic diseases. Then, we divided the networks into communities and assessed their temporal trends.

RESULTS

The results showed complex interactions among chronic diseases, with more intensive connections among males and inpatients ≥40 years old. A total of 9 chronic diseases were simultaneously classified as central diseases, hubs, and bursts in the multimorbidity networks. Among them, 5 diseases were common to both males and females, including hypertension, chronic ischemic heart disease, cerebral infarction, other cerebrovascular diseases, and atherosclerosis. The earliest leaps (degree leaps ≥6) appeared at a disorder of glycoprotein metabolism that happened at 25-29 years in males, about 15 years earlier than in females. The number of chronic diseases in the community increased over time, but the new entrants did not replace the root of the community.

CONCLUSIONS

Our multimorbidity network analysis identified specific differences in the co-occurrence of chronic diagnoses by sex and age, which could help in the design of clinical interventions for inpatient multimorbidity.
A randomised controlled trial of a conversational virtual avatar-led cognitive behavioural therapy app intervention for improving the quality of life and mental health of people with epilepsy. (Preprint)
Authors: Burbach Frank , Lecce Francesca , Allen Victoria M.E. , Porter Catherine M.
Published: June 2022

BACKGROUND

Epilepsy is a common neurological disorder affecting about 1 in 100 people in the UK. Many individuals experience a lower quality of life as a result of their epilepsy diagnosis and are more likely to develop mental health problems such as anxiety and depression. Medical interventions for this client group tend to focus on the treatment of seizures while mental health disorders often remain undiagnosed and untreated. Early identification and treatment of mental health difficulties in people with epilepsy are vital to ensure better outcomes and improve their quality of life.

OBJECTIVE

In this exploratory randomised controlled trial (RCT), we will evaluate whether an 8-week cognitive behavioural therapy (CBT)-based intervention delivered through a mobile app, ThinkNinja for epilepsy, is a clinically efficacious and effective tool to improve the quality of life, mental health and emotional wellbeing in a large sample of people with epilepsy and anxiety or co-morbid anxiety and depression.

METHODS

The study aims to recruit 184 individuals between 18 - 65 years of age with a self-reported diagnosis of epilepsy and anxiety, or comorbid anxiety and depression. Participants will be randomly assigned to either the ThinkNinja for epilepsy app condition (Arm A) or the waiting list control group (Arm B). Participants assigned to Arm A will receive access to ThinkNinja for epilepsy app first. The waiting list control group (Arm B) will receive the same full access to the ThinkNinja for epilepsy app as the participants in condition A after 8 weeks. This design will allow an initial between-subjects analysis between the two conditions as well as a within-subject analysis including all participants. The primary outcome is participants’ quality of life (QOLIE-10-P) while the secondary outcomes include measures of anxiety (GAD-7), depression (PHQ-9), medication adherence (MAQ) and impression of change (PGIC).

RESULTS

The recruitment of this study began in March 2022 and will run until October 2022.

CONCLUSIONS

This study aims to determine the clinical efficacy, effectiveness and safety of ThinkNinja for epilepsy at improving the quality of life, mental health and emotional wellbeing of people with epilepsy. The findings from our study will hopefully contribute to addressing the critical gap in universal provision and accessibility of mental health and emotional wellbeing support for people with epilepsy.

CLINICALTRIAL

ISRCTN 16270209 (04/03/2022)
A global analysis of COVID-19 infection fatality rate and its associated factors during the Delta and Omicron variant periods: Observational study (Preprint)
Authors: Nguyen Nhi Thi Hong , Ou Tsong Yih , Huy Le Duc , Shih Chung-Liang , Chang Yao-Mao , Phuc Phan Thanh , Huang Chung-Chien
Published: June 2022

BACKGROUND

As new variants keep emerging and threatening public health achievements, it is of great importance for governments to keep track of potential country-level pandemic indicators and traverse appropriate COVID-19 control remedies effectively and quickly.

OBJECTIVE

This study aims to compare COVID-19 average weekly infection fatality rate (AWIFR) and investigate factors associated with COVID-19 AWIFR over two periods of Delta and Omicron variants. Additionally, the study is to explore the factors linked to the increase in COVID-19 AWIFR between two periods of Delta and Omicron variants.

METHODS

We carried out an ecological study of 110 countries over the first twelve weeks during two periods of Delta and Omicron variant dominance, using publicly available databases. We calculated the AWIFR in aggregate data of twelve weeks in each period. Multivariable linear regression models were utilized to determine the factors associated with AWIFR and the increase in AWIFR between two periods.

RESULTS

The Omicron period was found to have a lower AWIFR than Delta period, although it exhibited greater rates of average weekly infection and average weekly fatality. During the Delta variant period, region, high government indicators, and proportion of the population fully vaccinated were significantly associated with a lower AWIFR, and high death rates caused by diabetes and kidney diseases were linked to higher AWIFR. During the Omicron variant period, countries with a high proportion of the population vaccinated with a booster dose had a significantly lower AWIFR, whereas the proportion of the population over 65, income levels, and years lived with disability (YLDs) caused by metabolic diseases were adversely linked with AWIFR. Over two periods of Delta and Omicron, we found a lower increase in AWIFR in countries with high levels of government effectiveness index and stringency index. In contrast, the countries with high death rates caused by diabetes and kidney, and the proportion of people aged over 65 were linked to a greater increase in AWIFR.

CONCLUSIONS

Our findings suggest that government needs to keep fostering the rates of vaccine coverage, enhancing coordination between the intensity and duration of non-pharmaceutical interventions, strengthening interventions for chronic diseases, and implementing more assessments on metabolic disorders to alleviate the COVID-19 outcomes.
Evaluating the Impact of Mask Mandates and Political Party Affiliation on Mental Health Internet Search Behavior in the United States During the COVID-19 Pandemic: Generalized Additive Mixed Model Framework (Preprint)
Authors: Gyorda Joseph A , Lekkas Damien , Price George , Jacobson Nicholas C
Published: June 2022

BACKGROUND

The impacts of the COVID-19 pandemic on mental health worldwide and in the United States have been well documented. However, there is limited research examining the long-term effects of the pandemic on mental health, particularly in relation to pervasive policies such as statewide mask mandates and political party affiliation.

OBJECTIVE

The goal of this study was to examine whether statewide mask mandates and political party affiliations yielded differential changes in mental health symptoms across the United States by leveraging state-specific internet search query data.

METHODS

This study leveraged Google search queries from March 24, 2020, to March 29, 2021, in each of the 50 states in the United States. Of the 50 states, 39 implemented statewide mask mandates—with 16 of these states being Republican—to combat the spread of COVID-19. This study investigated whether mask mandates were associated differentially with mental health in states with and without mandates by exploring variations in mental health search queries across the United States. In addition, political party affiliation was examined as a potential covariate to determine whether mask mandates had differential associations with mental health in Republican and Democratic states. Generalized additive mixed models were implemented to model associations among mask mandates, political party affiliation, and mental health search volume for up to 7 months following the implementation of a mask mandate.

RESULTS

The results of generalized additive mixed models revealed that search volume for “restless” significantly increased following a mask mandate across all states, whereas the search volume for “irritable” and “anxiety” increased and decreased, respectively, following a mandate for Republican states in comparison with Democratic states. Most mental health search terms did not exhibit significant changes in search volume in relation to mask mandate implementation.

CONCLUSIONS

These findings suggest that mask mandates were associated nonlinearly with significant changes in mental health search behavior, with the most notable associations occurring in anxiety-related search terms. Therefore, policy makers should consider monitoring and providing additional support for these mental health symptoms following the implementation of public health–related mandates such as mask mandates. Nevertheless, these results do not provide evidence for an overwhelming impact of mask mandates on population-level mental health in the United States.
Threats to Democracy
Authors: Nooteboom Bart
Published: June 2022

After a discussion of the literature on the development of societies and of the multiple causality of societies, this paper discusses 12 threats to democracy: autocracy, cultural decline, polarisation, elite paradox, populism, confusion, capitalism, dilemma of benevolence and justice, institutional crowding, sort-termism and depletion, AI and robots.
China's foreign direct investment in Mexico's auto parts-automotive industry:
Authors: Ortiz Velásquez Samuel , Prudencio Vazquez Jaime Alberto
Published: June 2022

In 2020 China displaced the United States as the main country of origin of cross-border M&A type investments and ranked fourth as the origin of new greenfield projects. In the regional context, since 2010 Mexico appears as the second destination of Chinese direct investment directed to manufacturing and as the first destination in the automotive auto parts industry (AAI). The article examines the determinants of Chinese direct investment in Mexico from a regional perspective and from the case study of the Chinese multinational Minth based on Aguascalientes, Mexico. The results allow us to conclude that the growing presence of direct investment by Chinese private companies in the AAI is explained by the favorable prospects for demand generated by the presence of global assemblers in Mexico and geographic and institutional variables such as the proximity whit United States, the agglomeration economies presence and benefits of the United States-Mexico-Canada Agreement (USMCA).
¿Cómo estudiar la migración en el sistema Meso-Norteamericano?
Authors: Schiavon Jorge A.
Published: June 2022

Este artículo responde la pregunta: ¿cómo se debe estudiar el fenómeno migratorio en el sistema Meso-Norteamericano? Esta pregunta se responde proponiendo cinco estrategias que permiten entender y analizar la migración de manera integral, a saber: 1) desagregar el análisis en los cinco componentes internacionales que lo integran (emigración, inmigración, tránsito, retorno y refugio 2) examinarlo regionalmente como un sistema migratorio; 3) estudiarlo multi-causalmente, organizando las variables en dos categorías (“push” y “pull”) y, posteriormente, desagregándolas en tipos de variables causales (políticas, económicas, de seguridad, medio ambiente, sociales, entre otras); 4) analizarlo racionalmente como un fenómeno y no como un problema; y, 5) evaluarlo identificando si se siguen las “5-Cs” de las buenas políticas migratorias (coherencia, consistencia, corresponsabilidad, coordinación y cooperación).
Estilos de vida estudiantes de primer semestre de odontología de una universidad privada, Cali 2016
Authors: Lara Parra Yeny Mabel , Quiroga Vásquez Claudia Patricia , Jaramillo Echeverry Adriana , Bermeo de Rubio Myriam
Published: June 2022

Objetivo: Identificar los estilos de vida de los estudiantes de primer semestre de Odontología en una universidad privada en el año 2016.Materiales y métodos: Estudio descriptivo, transversal, cuantitativo, con una muestra de 58 estudiantes de primer semestre de una universidad privada de Cali. Se diligenció de manera virtual y anónima el cuestionario FANTÁSTICO que consta de 25 preguntas cerradas de escala Likert, que mide varios dominios físicos, psicológicos y sociales relacionados con el estilo de vida. Se realizó análisis estadístico uni y bivariado con el programa Stata 13®, buscando asociación entre cada ítem y el resultado final con el sexo del estudiante, mediante la prueba chi2 con un alfa de 0,05.Resultados: Las categorías en las que se obtuvo un bajo puntaje fueron actividad física, alimentación, fumar, consumo de alcohol, hábitos de sueño y estrés. Hubo diferencias significativas en el consumo de cigarrillo, siendo mayor en hombres.Conclusión: El estilo de vida en la mayoría de los estudiantes fue excelente y bueno.Palabras clave: estilo de vida, estudiantes universitarios, cuestionario Fantástico.
Hacia el liderazgo transformacional en la educación superior: competencias para responder a la crisis del COVID-19
Authors: Muñoz-Chávez J. Patricia , Valle-Cruz David , Barrios-Quiroz Héctor , García-Contreras Rigoberto
Published: June 2022

Este artículo tiene como objetivo examinar las competencias asociadas al liderazgo transformacional para enfrentar la contingencia del COVID-19 por parte de los docentes de una institución de educación superior en México. El enfoque del estudio es cualitativo y transversal a partir de un estudio de caso, en el que se aplicaron entrevistas en profundidad semiestructuradas a los docentes y al líder de la institución. Los hallazgos resaltan la importancia de que el líder de la organización tenga la capacidad de motivar al personal, inspirar a la gente y dar confianza en tiempos de pandemia; además de impulsar una organización flexible, así como facilitar la generación de estrategias emergentes ante situaciones contingentes, apoyadas en el uso e implementación de tecnologías de la información que coadyuven a la supervivencia de las organizaciones.
Editorial. Entre transformaciones y reflexiones
Authors: Ulloa Hung Jorge
Published: June 2022

No necesita de un resumen.
A New Hybrid Solar-Wind Charging Station for Electric Vehicle Applications and Its Simulation
Authors: Chaudhari Mr. Subodh , Tibude Prof. Sneha
Published: June 2022

Abstract: Electric vehicles play a vital role in energy saving and emission reduction of harmful greenhouse gases. electrical vehicles dispersion into the vehicles market has not been up to the mark because of less value effective and these vehicles have to be compelled to be compelled to recharge once in sixty-five to seventy klick drive. The novel hybrid vehicle charging station carries with it fully totally different sources like PV systems, wind systems, the AC provide, batteries area unit used as a main energy storage system, kind DC little grid permanently energy delivery. Thus, grid offers decent quality of power to 3 totally different hundreds notably 110-volt AC single-phase output ,100 v DC output. The grid is at 230 V rms with fifty cps connected isolator in relation to the DC bus. The three-part output of the grid is regenerated to the rippled DC by utilization of DBR (Diode Bridge Rectifier). The regenerated DC voltage is fed to graphic symbol device that might be a DC-DC device, making the rippled DC to constant DC with the use of a buck device, this paper justifies comparative performance hybrid charging station mistreatment buck and letter convertor to stabilize the DC voltage. planned system analysis in MATLAB Simulink. Keywords: Charging station, DC grid, Electric vehicle, MATLAB Simulink
Database Security using Cryptography
Authors: Singhal Yash , Agarwal Adwit , Mittal Shivank , Katyayani Shristi , Sharma Amit
Published: June 2022

Abstract: There has been an explosion in data since last two decades and this explosion of data is due to high rates of data conversion and better internet services worldwide [21]. All the conventional methods of data handling have been replaced by much more sophisticated means. One of the typical shifts of the emerging information society is that information is becoming a crucial if not the most vital source. Information contrasts profoundly from further resources; for example and it can be imitative without cost, it can be erased without leaving traces. [22] Protecting the new resource information is a major issue in the information economy [20]. One such means is a Database. It makes it easier for data related queries butit can be dangerous if this data is leaked or sent outside the organization. A high price is positioned on confidentiality when information concerning statesecrets, business plans, war strategy, medical recordsand financial transactions needs to be stored or transmitted. Since its inception, the Internet has enable [19]. A cyber crime emerging in recent years data breachis one of the most notorious and disastrous data crimes majorly caused due to unsecure database. To secure these databases we can apply the concepts of AES algorithm. It is an algorithm used in cryptographywhich changes normal text to unreadable or cypher text. Keywords: Cryptography, AES, cypher, digitzation, confidentiality
HCI Based Virtual Controlling System
Authors: Thorat Sakshi
Published: June 2022

Abstract: Researchers around the globe are working on making our devices more interactive and making them function with minimal physical contact in this research project. The proposed system is an interactive computer system that can operate without a physical keyboard or mouse. This system will benefit everyone, particularly immobilized people with special needs operating a physical keyboard and mouse. So in the system, they have developed an interface that uses visual hand-gesture analysis. These gestures are used to assist those who are having trouble controlling or operating computers or gadgets. The model is being developed in such a way that it can assist us in recognizing and implementing it. Regarding hand gestures, our interface uses OpenCV, Python, and computer vision algorithms that can detect different finger orientations, distinguish the user's hand from the background, and distinguish significant hand movements from unwanted hand movements. Keywords: Machine Learning, Computer Vision, Image Processing, OpenCV, Human-Computer Interaction (HCI)
Arduino Based Congestion Control System for Ambulance
Authors: Rishitha Ch. , Bhavana M. , Sriya P. , Sreenivasulu Dr. Y.
Published: June 2022

Abstract: Congestion problem is a fact which contributed large impact on the transport system in the country. because many problems especially when there are emergency cases at traffic light junctions which are always busy with so many vehicles. A congestion control system is designed in order to solve all these problems. This system was designed in such a way that it should be activated when it receives a signal from an ambulance based on radio frequency (RF) transmission and uses a microcontroller to change the sequence back to the normal sequence before the emergency mode is activated. This system will lessen what often happens at the traffic light intersections because other vehicles have to gather together for giving a special route to an emergency vehicle. As a result, this project is successful and the implementation of wireless communication i.e. the radio frequency (RF) transmission in the traffic light control system for emergency vehicles like an ambulance is made possible. The main aim of this project is to design a system that is capable to identify an emergency situation in an ambulance and automatically controls the traffic at the signal. In the future, this system can be improved by controlling real traffic congestion, in fact improving the present traffic light system technology. The existing traffic control system has a lot of limitations because of its fixed time method used. The traffic signal will not alter based on the real-time traffic on road near the junction of two or more roads. Due to this, the traffic congestion cannot be controlled efficiently and the utilization of roads cannot be done to its maximum limit.
Organización y nuevos rasgos alimentarios en el campo mexicano: alternativas productivas en Ameca, Jalisco
Authors: Castillo Girón Víctor Manuel , Ayala Ramírez Suhey
Published: June 2022

Teniendo como referencia el municipio de Ameca, Jalisco, nuestro objetivo es identificar los productos alimentarios derivados de alternativas productivas locales y analizar sus características distintivas y factores que impulsan e inhiben su desarrollo. Conceptualmente definimos los productos locales por su grado de anclaje con los factores naturales del territorio, el nivel de participación de los productores en su transformación y comercialización, y el grado y tipo de consumo que ocurre localmente. Los datos se sustentan en información obtenida de 96 encuestas aplicadas a igual número de hogares seleccionados mediante los principios del muestreo aleatorio simple, así como de más de una veintena de entrevistas abiertas a los responsables de las alternativas productivas más relevantes de donde derivan los productos locales en cuestión. En las conclusiones destacamos que los nueve productos locales identificados guardan débiles vínculos territoriales y su valorización está limitada por las externalidades negativas del cultivo de caña de azúcar, el uso deliberado de acuerdos contractuales para contener la oferta o de nuevos participantes así como la falta de capacidad de gestión de los gobiernos locales que emparejadas con los huecos institucionales o reglas de operación de las políticas públicas alientan proyectos individuales en demérito de las acciones colectivas.
Redes sociales de investigación sobre sostenibilidad y agricultura: una oportunidad para generar sectores agroalimentarios resilientes
Authors: Núñez Espinoza Juan Felipe , Magdaleno Hernández Adalberto
Published: June 2022

Comprender la estructura de vínculos sociales involucrada en la generación de conocimientos científicos será un tema estratégico al momento de confrontar exitosamente las condiciones de cambio climático que están ejerciendo una continua presión sobre las capacidades agroalimentarias de las sociedades. En esta dirección, el objetivo de este documento fue analizar parte del perfil socio-estructural responsable del conocimiento científico agrícola en México. Esto permite un análisis topológico del proceso de gestión estructural de cualidades sociales, tales como confianza y reciprocidad, involucradas directamente en la generación de este tipo de conocimiento agrícola. Los resultados mostraron que en este tipo de estructuras sociales subyacen diversas capacidades que podrían ser útiles al momento de buscar construir sólidos sistemas de investigación para los sectores agroalimentarios, a fin de poder afrontar escenarios climáticos adversos.
Estado nutricional y su relación con la seguridad alimentaria en el medio rural de Oaxaca
Authors: Angeles Coronado Imelda A. , Herrera Haro José G. , Ortega Cerrilla María Esther , León Merino Aurelio , Periago-Castón María J. , Martínez Castañeda Francisco E. , Jerez Salas Martha Patricia
Published: June 2022

Las percepciones de seguridad alimentaria no garantizan un estado nutricional apropiado, este último se encuentra influenciado por la edad y condición fisiológica del individuo, y no por las sensaciones de saciedad. El objetivo de la investigación fue relacionar la percepción de la familia sobre su seguridad alimentaria (SA) con la diversidad de alimentos de que dispone y el aporte de macronutrientes de su dieta. Se muestrearon 100 familias y se determinó el tipo y cantidad de alimentos, el aporte de las proteínas, la grasa y los carbohidratos al valor calórico total (VCT) y la percepción de SA. Los resultados evidencian que el rezago social y la edad de los integrantes de la familia afectan negativamente al estado de SA. El aporte al VCT de las proteínas se adecuó a las recomendaciones oficiales, en torno a 12 %, la grasa tuvo un aporte inferior a 25% y los carbohidratos sobrepasaron 60%. El aporte de 80% de energía consumida proviene del maíz, trigo, frijol, aceite, arroz y en menor proporción de cárnicos. Se concluye que la ingesta energética, proteica y de grasas de la dieta son independientes de la percepción de SA que tienen las familias.
A Case Report of Elderly Delirium Treated with Shihogayonggolmoryo-tang
Authors: Lee Su-jung , Yang Ji-soo , Cho Eun-chai , Lew Jae-hwan
Published: June 2022

Objective: The purpose of this study is to report the effects of Shihogayonggolmoryo-tang on elderly delirium.Methods: A patient suffering from delirium was treated with Shihogayonggolmoryo-tang herbal therapy for 35 days. To evaluate the therapeutic effects, the Korean version of the Mini Mental State Examination (MMSE-K) and the Korean Nursing Delirium Screening Scale (nu-DESC) were used twice a week.Results: After treatment, the patient’s MMSE-K score increased from 0 to 12, and the nu-DESC results decreased 4 to 0.Conclusion: These scores suggest that therapy with Shihogayonggolmoryo-tang has a positive effect on elderly delirium.