bluuebunny/crossref_metadata_2025 huggingface dataset:
Geostatistical Integration of Yield Monitor Data and Remote Sensing Improves Yield Maps
Authors: Dobermann A. , Ping J. L.
Published: June 2021

Grain yield maps must accurately display general yield patterns as well as details of local yield variation. Different geostatistical procedures for creating interpolated yield maps by integrating yield data with remotely sensed vegetation indices (VI) were evaluated. Yield monitor data and a multispectral satellite image at 4‐m spatial resolution were collected in an irrigated maize (Zea maysL.) field and a rainfed soybean [Glycine max(L.) Merr.] field. Ordinary kriging (OK), cokriging (CK), simple kriging with varying local means (SKLM), and kriging with external drift (KED) were compared using grain yield as primary variable and three different VI as secondary variables. At both sites, SKLM performed best in terms of the precision of grain yield maps and maps that depicted true yield patterns. Utilizing the most suitable vegetation index at each site and SKLM as interpolation method, the root mean squared error of yield predictions was increased by nearly 20% over OK. Methods such as KED or CK resulted in only small improvement of yield maps over those obtained with OK. Utilizing the satellite image decreased errors associated with yield monitor operations and allowed better prediction in areas where no reliable yield measurements were available. Due to the robust nature of modeling the relationship between primary and one or more secondary variables, the SKLM method has considerable potential for use in commercial precision‐farming software. Future efforts on improving yield mapping should concentrate on obtaining improved yield monitor data and imagery and developing yield‐sensitive VI for high‐yielding crops.
Chaotic correlation functions with complex fermions
Authors: Bhattacharya Ritabrata , Jatkar Dileep , Kundu Arnab
Published: June 2021

We study correlation functions in the complex fermion SYK
model. We focus, specifically, on the h=2 mode which explicitly
breaks conformal invariance and exhibits the chaotic behaviour. We
numerically explore a fermion six-point OTOC, with two and three real-time folds, respectively. While our approach is expected to yield an early-time chaotic growth, we nevertheless observe a near-maximal value.
Following the program of Gross-Rosenhaus, we estimate the triple
short time limit of the six point function. Unlike the conformal
modes with high values of h, the h=2 mode has contact
interaction dominating over the planar in the large q limit.
MICROBIOLOGICAL AND PHYTOCHEMICAL ANALYSES OF SOME SELECTED HERBAL MIXTURES SOLD IN NIGERIA
Authors:   Department of Physics, Kogi State College of Education, Ankpa., Nwokike Angela
Published: June 2021

Over the years, medicinal plants have played significant role in traditional medicine practice. The rise in health-related problems, and the search for potential treatments and possible cures has led to the increased patronage of herbal drugs in Nigeria. there is an overwhelming increase in the production and distribution of herbal drugs and the trend has called for concern on the quality of the products been sold in Nigeria. thus, the primary purpose of the present study is to analyze the microbiological and phytochemical constituents of Okanga powder, Goko cleanser and Deep root herbal mixtures popularly sold in Nigeria. The phytochemical tests conducted on the herbal products revealed that the herbal products contain alkaloids, flavonoids, glycosides, anthraquinones, tannins, and saponins. The result of the microbial count indicates the presence of varying microorganisms such as S. aureus, E. coli, Salmonella and Klebsiella sppin the herbal products. The study concludes that the herbal products possess active phytochemicals, however, the presence of pathogenic organisms were discovered in the herbal drugs.
NIGERIAN YOUTH AND SAFETY CONSCIOUSNESS: DOES LEVEL OF EDUCATION AND SENSE OF SELF MATTER?
Authors:   Department of Education Planning & Administration, Federal College of Education, Eha Amufu Enugu State Nigeria., C. Onyeke Paul , C. Onyebukwa Nwanoro ,   Department of Education Planning & Administration, Federal College of Education, Eha Amufu Enugu State Nigeria.
Published: June 2021

The study was conducted to determine safety consciousness among Nigerian youth based on educational level and individuals sense of self. The purpose was to ascertain whether the level of youth education and how the youths subjective perception of themselves will influence how the youth respond to insecurity situations. A total of two hundred respondents drawn from the general public completed the Security Consciousness Questionnaire and the Rosenberg Self Esteem Scale. Multiple regression analysis was conducted on the data, and the result showed that sense of self significantly predicted safety consciousness while educational level failed to influence the dependent variable. Implications and recommendations are discussed.
RELIGIOUS COMMITMENT, SELF-ESTEEM, AND ATTITUDE TOWARDS THE PHYSICALLY CHALLENGED PERSONS IN NIGERIA
Authors:   Department of Religion, Federal College of Education Eha Amufu, Enugu State, Nigeria., a Camillus , Udaya O. ,   Department of Religion, Federal College of Education Eha Amufu, Enugu State, Nigeria., O. Ajogwu Janet ,   Department of Religion, Federal College of Education Eha Amufu, Enugu State, Nigeria.
Published: June 2021

The purpose of the current study was to examine the attitudes of Nigerians towards physically challenged persons. The population of the study constituted civil servants. A total of two hundred and twenty participants comprising males and females were randomly selected from the Enugu and Kogi states civil service as the research participants. Data for the study was generated using three research instruments, including the 24-item Scale of Attitude Toward Disabled Persons (SADP), The Religious commitment inventory (RCI-10), and Rosenbergs self-esteem scale (R-SES). The multiple regression analysis results showed that religious commitment significantly predicted attitude towards physically challenged persons. However, the findings also found no significant influence of self-esteem on attitude towards the physically challenged. It is recommended that more research be conducted to fully understand the determinants of attitudes towards the physically challenged in society.
THE EDUCATION MANAGEMENT INFORMATION SYSTEM (EMIS) AND THE EDUCATIONAL INFORMATION MANAGEMENT IN NIGERIA
Authors:   Department of Computer Science, Federal College of Education, Eha Amufu, Enugu State, Nigeria., K. Taiwo Olayanju , C. Okwor Charity ,   Department of Computer Science, Federal College of Education, Eha Amufu, Enugu State, Nigeria.
Published: June 2021

This study examined the impact of the education management information system (EMIS) on Nigerias educational information management, emphasizing tertiary institutions. The study aimed to examine the difficulties associated with accessing information in the tertiary institutions based on the absences of EMIS. A total of one hundred and eighteen undergraduates and graduates were randomly selected for the study. A self-developed instrument was used for data collection, and a simple linear regression was conducted on the data. The result implicated the absence of EMIS in the observed difficulties/challenges of information management in the school system. Finding, strengths, weaknesses, and conclusions are discussed.
PHYSICOCHEMICAL ANALYSIS & STANDARDIZATION OF SHIRISH TWAK KWATH CHURNA
Authors:   MD Scholar at UAU in Agadtantra, Rishikul Campus, Haridwar, Uttrakhand, India., Neha Shah , Amita Jhunjhunwala ,   Associate Professor at UAU in Agadtantra, Gurukul Campus, Haridwar, Uttrakhand, India.
Published: June 2021

As per Ayurvedic classics no herb in the earth is devoid of medicinal properties.In many Ayurvedic texts it is mentioned to use Shirish for various therapeutic purposes like Kustha (skin diseases), Premeha (diabetes), Swasrogas (bronchial asthma), Vranaropaka (wound healer), Sothahara (anti-inflammatory) and many more. Acharya Charak has mentioned Shirish as Sresthavishagnadravya (anti-toxic). Aim- Pharmaceutical preparation and standardization of Shirish twakkwathchurna. Material & Method-Shirish twakkwathchurna was prepared and its physicochemical testing & standardization was done by following the standard protocols. Results-Shirish twakKwathchurna was evaluated for different standardization parameters which showedLoss on drying (5.30%), Total ash (12.68%), Acid insoluble ash (1.24%), Water soluble extractive (4.69%) and Alcohol soluble Extractive (5.56%). Conclusion-Each plant is the gift of nature which can used for the well-being of mankind but this can only be done when we are well aware of its physicochemical properties. This paper highlights the physicochemical picture of widely used plant Shirish and the data developed from the study can be espoused for allocating the standards for Shirish twakkwathchurna.
PURE GONADAL DYSGENESIS: CLINICAL CASE AND REVIEW OF THE LITERATURE
Authors:   Gynecology-Obstetrics, Souissi Maternity Hospital, Mohamed V University - Rabat - Morocco., Watfeh Rana , Benani Adam ,   Gynecology-Obstetrics, Souissi Maternity Hospital, Mohamed V University - Rabat - Morocco., Hijji Maria ,   Gynecology-Obstetrics, Souissi Maternity Hospital, Mohamed V University - Rabat - Morocco., Youssfi M. ,   Gynecology-Obstetrics, Souissi Maternity Hospital, Mohamed V University - Rabat - Morocco., Bargach S. ,   Gynecology-Obstetrics, Souissi Maternity Hospital, Mohamed V University - Rabat - Morocco.
Published: June 2021

XX or XY pure gonadal dysgenesis (PGD) is defined by premature destruction of the fetal gonads which reduce to an undifferentiated stroma with absence of germ line and endocrine secretion. The phenotype is unambiguously female with a clinical picture associating primary amenorrhea and impuberty. We present in this article a clinical case illustrating this pathology in a young patient who presents a primary amenorrhea. The diagnosis of pure XX gonadal dysgenesis was retained based on the clinical and para-clinical examinations. The patient was treated with hormone replacement therapy. The chances of fertility are almost absent in our context, and the only way out is egg donation.
BREAST CANCER AND PREGNANCY: HOW TO PROCEED?
Authors:   Department of gynecology-obstetrics, Oncology and High-Risk Pregnancies, Souissi Maternity Hospital Mohamed V University- Rabat - Morocco., Watfeh Rana , Serroukh M. ,   Department of gynecology-obstetrics, Oncology and High-Risk Pregnancies, Souissi Maternity Hospital Mohamed V University- Rabat - Morocco., Kamri Fz ,   Department of gynecology-obstetrics, Oncology and High-Risk Pregnancies, Souissi Maternity Hospital Mohamed V University- Rabat - Morocco., Yousfi M. ,   Department of gynecology-obstetrics, Oncology and High-Risk Pregnancies, Souissi Maternity Hospital Mohamed V University- Rabat - Morocco., Bargach S. ,   Department of gynecology-obstetrics, Oncology and High-Risk Pregnancies, Souissi Maternity Hospital Mohamed V University- Rabat - Morocco.
Published: June 2021

Breast cancer is one of the most frequent solid tumors associated with pregnancy. The prevalence is constantly increasing with a high character and a greater frequency of advanced forms involving the maternal and fetal prognosis. Clinical, ultrasound, cytological and histological diagnosis of cancer, although slightly more difficult, is possible during pregnancy. The histological types encountered correspond to breast cancers encountered outside the pregnancy period. The prognosis of breast cancer does not appear to be affected by pregnancy, provided that it does not interfere with or delay the initiation of diagnostic and treatment procedures. Decisions should be made in a multidisciplinary meeting to ensure that the patient and her partner are as fully informed as possible about the consequences of the cancer and the possible impact of treatment on the future of their child. Breastfeeding should not be prohibited when the cancer is in complete remission. It is important to mention though that it is usually recommended that a woman who has breast cancer wait two years after completing treatment before allowing a subsequent pregnancy.
The impact of firm size on the performance of Vietnamese private enterprises: A case study
Authors: Vu Hung Cuong , Phi Vinh Tuong , Dang Thai Binh
Published: June 2021

This article investigates the effect of firm size on the performance of Vietnamese private enterprises. Based on the data from the Annual Enterprise Survey from 2009 to 2018, this study uses an ordinary least-squares regression model (OLS) to point out the effects of firm size (growth rate, total assets, and total labor) on the performance of Vietnamese private enterprises in both static and dynamic states. According to the results of the quantitative model, total assets are the biggest factor for determining firm performance, followed by total labor and growth rate. The results highlight the issue in Vietnamese private enterprises development in terms of scale, despite the fact that their number is growing, as the scale of enterprises decreases (the proportion of micro and small enterprises increases, but the proportion of medium and big enterprises decreases). Besides, the disadvantages of scale also negatively affect the development process of Vietnamese private enterprises, including accessing capital, increase in production or productivity, business expansion, and improving competitiveness.
AcknowledgmentsThis research is supported by the National Science Project “Development of Private Enterprises in the Southwest Region in the new context” (KHCN-TNB/14-19/X15).
Technical and economical viability of a graywater recycling system employing an integrated preliminary settlement and filtration process
Authors: ShiGuang Chen , QiuLi Chen , Yu Zhang
Published: June 2021

The collection and reuse of graywater has become an important strategy for achieving the goal of sustainable development. In this work, an integrated preliminary settlement and filtration process was developed for treating shower water which was obtained from a college bathroom toilet. The system's pollutant removal efficiency was examined for three different filter media: manganese sand, quartz sand and ceramsite. The results showed that for ceramsite, the average removal of turbidity, CODcr, NH3-N, and anionic surfactant was 93.3%, 68.6%, 78.9, and 83.5% respectively. For manganese sand, the values were 84.6%, 61.5%, 57.8 and 59%, while for quartz, they were 88.9%, 47.9%, 39.5% and 51.9%. A cost–benefit analysis revealed that the payback period of graywater recycling systems ranges from 3.16–5.30 years and benefit–cost ratios are in the range of 1.23–1.67, depending on tank size. The proposed system provides a new strategy for enhancing water-use efficiency in buildings in a more decentralized way.
MAIN DIRECTIONS OF STATE SUPPORT IN INNOVATIVE ACTIVITIES RESIDENT ORGANIZATIONS OF TECHNOPOLIS
Authors: Panfilova Elena Evgenevna
Published: June 2021

The article is devoted to the consideration of the principles, methods and mechanisms of state support for industry in "points of growth" - special economic zones. The issues of state innovation policy in relation to small and medium-sized businesses are considered, key features of state support for resident companies are highlighted.
Reflection of Functions and Linear Prognosis
Authors: Pavlov Andrei Valerianovich
Published: June 2021

Periodicity of wide class of functions as a result of reflection of even and arbitrary regular functions is proved. By consideration of new scalar work in space of linear shell of initial n vectors the equivalence of values of two different scalar productions is proved. The example of linear transformation is considered on plane for the symmetric case, resulting in possibility to make to use the orthogonal sides of rhombus at projection on the plane of its parties.
Social well-being of families in light of regional social policy
Authors: Mehrishvili Lamara L. , Tkachjova Nina A. , Judashkin Andrej V.
Published: June 2021

This article studies the social well-being of the families of the Tyumen Region (excluding the Khanty-Mansi Autonomous Area — Yugra and Yamalo-Nenets Autonomous Area). This article considers the theoretical approaches to the concept of “social well-being” presented in the Russian academic literature. The results of a sociological study conducted by the authors in 2020 are presented. The novelty of the research lies in highlighting the specifics of intraregional differentiation of the influence of factors influencing the social well-being of families. The main research method was a questionnaire survey, which allowed providing a quantitative description of the phenomenon under consideration. The construction of the research sample model was carried out taking into account the center-peripheral model, which implies the analysis of the data obtained in the context of various types of territories represented in the region. The volume of the quota sample of the study was 1,200 people — the representatives of regional families with children. The main goal of the article is to determine the general level of social well-being of regional families, as well as to show its specificity in such social-territorial communities as a large city, a small town, rural settlements of the central type and peripheral villages. The following were considered as the components of social well-being: satisfaction with various aspects of life; availability of social infrastructure facilities; assessment of the state of various spheres of life; problems that concern families, their needs. Based on the results of the analysis, it was concluded that in different types of settlements, the level and nature of social well-being change. This circumstance should become the object of close attention of the authorities implementing social policy. The authors noted the need to develop a social policy that takes into account the spatial characteristics of the region. At the same time, the research component is of great importance, which makes it possible to analyze the problems of families in a territorial context, and it is also important to develop clear criteria for the classification of socio-territorial communities, taking into account the tendencies of their changes over time.
Erken Çocukluk Dönemindeki Sığınmacı ve Türk Asıllı Çocukların Okula Uyum Sürecinin Analizi
Authors: Türker-üçüncü Şenay , Aktan Acar Ebru
Published: June 2021

Suriye'de yaşanan iç savaşın uzaması ve memleketini terk edip gelen sığınmacıların ülkelerine geri dönememelerinden dolayı bir çok çocuk farklı ülkelerde ve kademelerde okula gitmeye başlamıştır. Sığınmacı çocukların acil olarak karşılanması gereken ihtiyaçlarının başında da eğitim ihtiyacı gelmektedir. Bu araştırma, erken çocukluk döneminde okul öncesi eğitimi alan, sığınmacı ve Türk asıllı çocukların okula uyum sorunlarını belirlemek amacıyla yürütülmüştür. Çocukların dil engeli ve yaşadıkları travmanın okula uyumlarına etkisinin incelendiği bu çalışmada çocuk gözlemleri, ebeveyn ve eğitmen görüşleri alınmak suretiyle nitel araştırma modellerinden Durum Araştırması uygulanmıştır. Araştırmanın çalışma grubunu, Çanakkale Onsekiz Mart Üniversitesi ÇABA Çok Amaçlı Erken Çocukluk Eğitimi Merkezi’nde (ÇABAÇAM) kayıtlı 4 sığınmacı çocuk ve özellikle gelişimsel olarak dezavantajlı ailelerden gelen 4 Türk asıllı çocuk, ebeveynleri ve 11 eğitmen oluşturmaktadır. Katılımcılar amaçlı örnekleme yöntemlerinden Ölçüt Örneklemesi olarak nitelendirilen örneklem türü kullanılarak belirlenmiş, verilerin analizinde betimsel analiz yöntemi kullanılmıştır. Araştırmanın sonucunda sığınmacı çocukların okula uyumunu etkileyen en önemli faktörün dil sorunu olduğu görülmüştür.
Cannabinoids and Myocardial Ischemia: Novel insights, Updated
Mechanisms, and Implications for Myocardial Infarction
Authors: Seif El Dahan Karim , Machtoub Dima , Massoud Gaelle , Nasser Suzanne A. , Hamam Bassam , Kobeissy Firas , Zouein Fouad A. , Eid Ali H.
Published: June 2021

:

Cannabis is the most widely trafficked and abused illicit drug due to its calming
psychoactive properties. It has been increasingly recognized as having potential
health benefits and relatively less adverse health effects as compared to other illicit
drugs; however, growing evidence clearly indicates that cannabis is associated with considerable
adverse cardiovascular events. Recent studies have linked cannabis use to myocardial
infarction (MI); yet, very little is known about the underlying mechanisms. A MI
is a cardiovascular disease characterized by a mismatch in the oxygen supply and demand
of the heart, resulting in ischemia and subsequent necrosis of the myocardium.
Since cannabis is increasingly being considered a risk factor for MI, there is a growing
need for better appreciating its potential health benefits and consequences. Here, we discuss
the cellular mechanisms of cannabis that lead to an increased risk of MI. We provide
a thorough and critical analysis of cannabinoids’ actions, which include modulation
of adipocyte biology, regional fat distribution, and atherosclerosis, as well as precipitation
of hemodynamic stressors relevant in the setting of a MI. By critically dissecting the
modulation of signaling pathways in multiple cell types, this paper highlights the mechanisms
through which cannabis may trigger life-threatening cardiovascular events. This
then provides a framework for future pharmacological studies which can identify targets
or develop drugs that modulate cannabis’ effects on the cardiovascular system as well as
other organ systems. Cannabis’ impact on the autonomic outflow, vascular smooth muscle
cells, myocardium, cortisol levels and other hemodynamic changes are also mechanistically
reviewed.
123I-Ioflupane SPECT and 18F-FDG PET Combined Use in the Characterization of Movement and Cognitive Associated Disorders in Neurodegenerative Diseases
Authors: Nuvoli Susanna , Tanda Giovanna , Stazza Maria L. , Palumbo Barbara , Frantellizzi Viviana , De Vincentis Giuseppe , Spanu Angela , Madeddu Giuseppe
Published: June 2021

Background:

Both movement (MD) and cognitive (CD) disorders can occur associated
in some neurodegenerative diseases, such as Parkinson’s disease (PD) and Alzheimer’s disease
(AD).

Objective:

We further investigated the usefulness of 123I-Ioflupane SPECT and 18F-FDG PET
combined use in patients with these disorders in the early stage.

Methods:

We retrospectively enrolled twenty-five consecutive patients with MD and CD clinical
symptoms of recent appearance. All patients had undergone neurologic examination, neuropsychological
tests, and magnetic resonance imaging. 123I-Ioflupane SPECT was performed in all cases,
followed by 18F-FDG PET two weeks later. In the two procedures, both qualitative (QL) and quantitative
(QN) image analyses were determined.

Results:

In patients with both 123I-Ioflupane SPECT and 18F-FDG PET pathologic data, associated
dopaminergic and cognitive impairments were confirmed in 56% of cases. Pathologic SPECT
with normal PET in 16% of cases could diagnose MD and exclude an associated CD, despite clinical
symptoms. On the contrary, normal SPECT with pathologic PET in 28% of cases could exclude
basal ganglia damage while confirming CD. QN 123I-Ioflupane SPECT analysis showed better performance
than QL since QN correctly characterized two cases of MD with normal QL. Moreover,
correct classification of normal metabolism was made only by QN analysis of 18F-FDG PET in
four cases, despite suspect areas of hypometabolism at QL.

Conclusion:

The combined use of these imaging procedures proved a reliable diagnostic tool to accurately
identify and characterize MD and CD in early stage. QN analysis was effective in supporting
QL evaluation, and its routine use is suggested, especially with inconclusive QL.
Reactive Oxygen Species (ROS): Key Components in Cancer Therapies
Authors: Sahoo Biswa Mohan , Banik Bimal Krishna , Borah Preetismita , Jain Adya
Published: June 2021

Reactive Oxygen Species (ROS) refers to the highly reactive substances which contain oxygen radicals.
Hypochlorous acid, peroxides, superoxide, singlet oxygen, alpha-oxygen, and hydroxyl radicals are the major examples
of ROS. Generally, the reduction of oxygen (O2) in molecular form produces superoxide (•O2
−) anion. ROS are
produced during a variety of biochemical reactions within the cell organelles, such as endoplasmic reticulum, mitochondria,
and peroxisome. Naturally, ROS are also formed as a byproduct of the normal metabolism of oxygen. The
production of ROS can be induced by various factors such as heavy metals, tobacco, smoke, drugs, xenobiotics, pollutants,
and radiation. From various experimental studies, it is reported that ROS acts as either a tumor-suppressing or a
tumor-promoting agent. The elevated level of ROS can arrest the growth of tumors through the persistent increase in
cell cycle inhibition. The increased level of ROS can induce apoptosis by both intrinsic and extrinsic pathways. ROS is
considered to be a tumor-suppressing agent as the production of ROS is due to the use of most of the chemotherapeutic
agents in order to activate cell death. The cytotoxic effect of ROS provides impetus towards apoptosis, but in higher
levels, ROS can cause initiation of malignancy that leads to uncontrolled cell death in cancer cells. In contrast, some
species of ROS can influence various activities at the cellular level, including cell proliferation. This review highlights
the genesis of ROS within cells by various routes and their role in cancer therapies.
Evaluation of Silibinin-Loaded Microbubbles Combined with Ultrasound in Ovarian Cancer Cells: Cytotoxicity and Mechanisms
Authors: Zhou Liguang , Liu Jing , Meng Wen , Zhang Huawei , Chen Bo
Published: June 2021

Background:

The anticancer activity of silibinin (SB) has been demonstrated in various cancer cell types.
However, its low solubility and poor bioavailability limit its clinical potential in biomedical applications. Microbubbles
in combination with ultrasound are promising vehicles for local drug delivery.

Objective:

The present study determined the antitumour effects and molecular mechanism of silibinin-loaded microbubbles
(SBMBs) in combination with ultrasound on ovarian cancer in vitro.

Methods:

SBMBs were prepared using mechanical vibration. The viability of A2780 cells was determined using the
MTT assay. Flow cytometry was performed to detect cell apoptosis and the cell cycle. The expression of Receptor
Tyrosine Kinase (RTK)-associated downstream proteins was detected using multiplex assays and Western blots.

Results:

The present study designed and synthesized SBMBs. SBMBs in combination with ultrasound decreased
A2780 cell viability in a dose- and time-dependent manner. The half maximal inhibitory concentration (IC50) showed
that the cytotoxicity of the SBMBs was approximately 1.5 times greater than that of the SB in A2780 cells. SBMBs in
combination with ultrasound resulted in significantly higher apoptosis efficiency compared to the SB group, and the
SBMB population of cells was arrested in the G1/G0 phase. Further experiments demonstrated that SBMBs decreased
the expression of signal transducer and activator of transcription 3 (STAT3), Ak strain transforming (AKT), and extracellular
signal-regulated kinase (Erk) and had a greater effect than SB in A2780 cells. Inhibitors of AKT, Erk and
STAT3 promoted the cytotoxicity of SBMBs.

Conclusion:

SBMBs in combination with ultrasound may enhance the cytotoxicity efficiency of SB via the promotion
of apoptosis and cell cycle arrest in ovarian cancer cells and the inactivation of the STAT3, AKT and Erk signalling
pathways.
A Pan-cancer Analysis Reveals the Abnormal Expression and Drug Sensitivity of CSF1
Authors: Dai Xiaoshuo , Chen Xinhuan , Chen Wei , Chen Yihuan , Zhao Jun , Zhang Qiushuang , Lu Jing
Published: June 2021

Background:

Colony-stimulating factor-1 (CSF1) is a cytokine that is closely related to normal
organ growth and development as well as tumor progression.

Objective:

We aimed to summarize and clarify the reasons for the abnormal expression of CSF1 in tumors and
explore the role of CSF1 in tumor progression. Furthermore, drug response analysis could provide a reference
for clinical medication.

Methods:

The expression of CSF1 was analyzed by TCGA and CCLE. Besides, cBioPortal and MethSurv databases
were used to conduct mutation and DNA methylation analyses. Further, correlations between CSF1 expression
and tumor stage, survival, immune infiltration, drug sensitivity and enrichment analyses were validated
via UALCAN, Kaplan-Meier plotter, TIMER, CTRP and Coexperia databases.

Results:

CSF1 is expressed in a variety of tissues; meaningfully, it can be detected in the blood. Compared with
normal tissues, CSF1 expression was significantly decreased in most tumors. The missense mutation and DNA
methylation of CSF1 might cause the downregulated expression. Moreover, decreased CSF1 expression was
related to higher tumor stage and worse survival. Further, the promoter DNA methylation level of CSF1 was
prognostically significant in most tumors. Besides, CSF1 was closely related to immune infiltration, especially
macrophages. Importantly, CSF1 expression was associated with a good response to VEGFRs inhibitors, which
may be due to the possible involvement of CSF1 in tumor angiogenesis and metastasis processes.

Conclusion:

The abnormal expression of CSF1 could serve as a promising biomarker of tumor progression and
prognosis in pan-cancer. Significantly, angiogenesis and metastasis inhibitors may show a good response to
CSF1-related tumors.
A Torsion Relative Angle Measurement Method Based on Fiber-Loop
Ring-Down with Intra-Cavity Amplification
Authors: Ma Tao , Tian Yongsheng , Liu Shaohui , Ma Jiahe , Liu Heng , Wang Fang , Zhou Ziqiang
Published: June 2021

Background:

The fiber-loop ring-down spectroscopy technique has the benefits of optical
fiber sensors and also has many unique advantages. Combined with various sensor structures, the
FLRD system can achieve different physical, chemical, and biological sensors.

Objective:

To find a way to solve the problems of light fluctuation and low sensitivity, high sensitivity,
and reliability torsion relative angle measurement system is necessary.

Methods:

The torsion relative angle measurement is achieved by using the fiber loop ring-down intra-
cavity amplification. The sensitivity, correlation coefficient, and repeatability are analyzed with
the experiment.

Results:

The sensitivity and correlation coefficient of the proposed system are 4.05 μs/° and 0.9996,
respectively. The repeated experiments show that the standard deviation is 9.592×10-4.

Conclusion:

The proposed measurement method provides a way to solve the problems of light fluctuation
and low sensitivity and has promising applications in the optically active solutions, fiber radial
stress birefringence and polarization state measurement of fiber lasers.
A Method of Quantifying Refrigerant Distribution in a Two-Pass
Micro-Channel Evaporator
Authors: Xu Geng , Chen Hua , Zhao Songtian , Ren Shusong , Zhao Wei
Published: June 2021

Background:

The flow rate distribution in the flat tubes of a micro-channel evaporator
is essential for its heat transfer performance. Due to a large number of flat tubes in a microchannel
evaporator, the flow rate distribution is often difficult to determine.

Objective:

An evaporator test rig was constructed to study the quantification of the refrigerant
mass flow rate distribution in a two-pass evaporator without destroying its structure.

Methods:

A heat transfer performance test rig for a two-pass evaporator was utilized. Subcooled
refrigerant R134a was pumped into the inlet header, and infrared thermography was used to obtain
the cloud map of the wall temperature distribution on the surface of the evaporator. The flow rate
distribution in each flat tube was calculated based on an analysis that combines the heat balance
between the air side and the refrigerant side with the effectiveness-Number of Transfer Units (ε-
NTU) method.

Results:

The flow rate distribution was found to be in good agreement with the evaporator wall
temperature distribution.The difference between the calculated and measured total mass flow rates
was less than 15.9%, which proves that the method is simple and effective. And the unevenness of
flow rate distribution in the 1st and 2nd pass is 0.13 and 0.32, respectively.

Conclusion:

This method is simple and effective, and does not destroy the structure of the microchannel
evaporator. However, it is only suitable for cases in which there exists a subcooled zone in
a pass, and is not applicable to a pass in which the refrigerant is only in a single-phase or a twophase
state.
PENINGKATAN AKTIVITAS BELAJAR MATEMATIKA PESERTA DIDIK KELAS XI KR3 SMK NEGERI 3 YOGYAKARTA MELALUI PEMBELAJARAN KOOPERATIF TWO STAY TWO STRAY
Authors: Daniati Arga
Published: June 2021

Based on the low participation of the student during the classroom activities, this study aimed to improve students’ participation and academic achievement on Mathematics. The procedures of this study consisted of planning, implementation, observation, and reflection. There were 24 students of Class XI KR 3 SMK N 3 Yogyakarta 2013/2014 participated in this study. Data were obtained through observation sheets, student worksheets, test, and notes. This study implemented a Cooperative learning model action at Two Stay Two Stray. The students were divided into 6 groups (each group consisted 4 students). The results revealed that (1) the students who actively participated in the classroom activities are 77.08%; (2) the students who passed the test 77.35%, and (3) the students who passed the minimum criteria for the study are 87.5%. It can be concluded that implementing Cooperative Learning, Two Stay Two Stray model, is effective to enhance students’ participation and academic achievement in mathematics.
XXV Международный симпозиум Нанофизика и наноэлектроника", Нижний Новгород, 9-12 марта 2021 г. Излучательные свойства ап-конверсионных покрытий, формируемых на основе ксерогелей титаната бария, легированных эрбием
Authors: Гапоненко Н.В. , Корнилова Ю.Д. , Лашковская Е.И. , Живулько В.Д. , Мудрый А.В. , Радюш Ю.В. , Андреев Б.А. , Степихова М.В. , Яблонский А.Н. , Гусев С.А. , Subasri R. , Reddy D.S.
Published: June 2021

Исследована стоксова и антистоксова люминесценция эрбия в ксерогелях титаната бария (BaTiO3 : Er), полученных золь-гель методом, и в многослойных покрытиях BaTiO3/SiO2, сформированных на кремниевых подложках. Показано, что ап-конверсия эрбия в ксерогелях титаната бария, сформированных с использованием нитрата или ацетата эрбия, наблюдается при концентрации эрбия > 3 ат%. Ап-конверсия эрбия наблюдается на длине волны возбуждения ~ 980 нм и характеризуется интенсивной полосой в области 520-560 нм, соответствующей излучательным переходам иона эрбия 2H11/2->4I15/2 и 4S3/2->4I15/2, а также полосами в области 650 и 850 нм, связанными с переходами 4F9/2->4I15/2 и 4I9/2->4I15/2. На основе полученных ксерогелей BaTiO3 : Er на кремниевых подложках сформированы многослойные структуры BaTiO3 : Er/SiO2/Si, обеспечивающие значительное, по сравнению с однослойными структурами BaTiO3 : Er/Si, усиление интенсивности люминесценции эрбия на длине волны основного излучательного перехода (1540 нм). Обсуждаются перспективы разработки ап-конверсионных покрытий на основе титаната бария, легированного эрбием, для практических применений. Ключевые слова: титанат бария, эрбий, ап-конверсия, люминесценция, золь-гель метод, многослойные структуры.
Мощность насыщения оптического усилителя на основе самоорганизующихся квантовых точек
Authors: Жуков А.Е. , Крыжановская Н.В. , Моисеев Э.И. , Надточий А.М. , Зубов Ф.И. , Фетисова М.В. , Максимов М.В. , Гордеев Н.Ю.
Published: June 2021

Gain saturation in a semiconductor optical amplifier with an array of quantum dots was studied analytically and by numerical simulation on the basis of an analysis of the rate equations. It is shown that, at a moderate injection level, the saturation power increases in proportion to the current density, and then reaches its maximum value, limited by the rate of capture of charge carriers to the ground state and by the number of quantum dots interacting with photons. Expressions are proposed that allow an explicit description of the dependence of the saturation power on the current and its relationship with the internal parameters of the active region.
Needs and Experiences of Users of Digital Navigation Tools for Mental Health Treatment and Supportive Services: Survey Study (Preprint)
Authors: Stafford Elizabeth , Brister Teri , Duckworth Ken , Rauseo-Ricupero Natali , Lagan Sarah
Published: June 2021

BACKGROUND

Despite a recent proliferation in web-based and digital resources that are designed to assist users in finding appropriate mental health treatment and supportive services, it can be overwhelming, confusing, and difficult for an individual or family member to access and use an appropriate navigation tool. As digital resources are increasingly sought after, there is an urgent need for a clearer understanding of digital navigation tools in order to help link individuals with the tool that is best suited to their needs.

OBJECTIVE

The objective of this study was to determine the needs of individuals seeking mental health treatment and supportive services and to quantify their experiences and satisfaction with available digital navigation tools.

METHODS

A survey was offered via an email newsletter and social media posting throughout the extended membership of the National Alliance on Mental Illness, which includes both individuals with a mental health condition and their family members and support networks. A 13-item anonymous survey, which consisted of multiple-choice and open response options, was developed to measure participants’ past use of and experiences with web-based, mobile, and phone-based navigation tools. The survey was available from April 9 through May 21, 2020.

RESULTS

A total of 478 respondents completed the survey; the majority of respondents were female (397/478, 83.1%) and aged ≥35 years (411/478, 86%). Younger respondents were more likely to report seeking mental health services for themselves, while older respondents were more likely to be searching for such services on behalf of a family member. The majority of respondents seeking such services on behalf of a family member (113/194, 58.2%) required a combination of mental health treatment and supportive services. Furthermore, two-thirds of respondents (322/478, 67.4%) used a navigation tool to find treatment or services. The majority of respondents who provided feedback about their experiences with navigation tools (224/280, 80%) reported difficulties, with data availability and accuracy being the most commonly reported issues.

CONCLUSIONS

The survey results suggest that issues with data availability and accuracy in available navigation tools remain a major barrier for locating timely and appropriate mental health treatment and supportive services within the population of individuals seeking such services. Particularly for individuals seeking care on behalf of a family member, improving the accuracy of and users’ experiences with navigation tools could have a major impact on effectively connecting people to treatment and support services.
Digital Divide of Shattered “Iron Rice Bowl”: Economic Insecurity and Digital Divide in China (Preprint)
Authors: Li Zhuo , Yin Haijie , Wang Teng
Published: June 2021

BACKGROUND

Although economic factors account for the digital divide, the effect of economic insecurity on digital access has not been determined. The market-oriented reform of the Chinese State-Owned Enterprises in the 1990s resulted in massive layoffs, encouraging us to investigate the relationship between economic insecurity and the digital divide.

OBJECTIVE

First, the study investigates the relationship between economic insecurity and the digital divide. Second, the study provides insight into m-health for policymakers in the context of the worldwide COVID-19 pandemic.

METHODS

We draw on data from the China Health and Retirement Longitudinal Study (CHARLS 2011) and CHARLS Life History Survey (2014). To handle endogenous problems related to economic insecurity, we introduced instrumental variables to our models. We also divided digital access into personal and infrastructure information communication technology (ICT).

RESULTS

We found a negative relationship between economic insecurity and the digital divide only in infrastructure ICT. Additionally, we found that only chronic disease contributes to the digital divide among older people.

CONCLUSIONS

Older people are confronted with a dual digital divide: health-related and economic insecurity-related.This study provides insight into mobile health policy involving underprivileged people under the context of economic insecurity triggered by COVID-19.
Mobile Applications for Mental Health Self-care: A Scoping Review (Preprint)
Authors: Ahmed Arfan , Ali Nashva , Giannicchi Anna , Abd-Alrazaq Alaa A , Ahmed Mohamed Ali Siddig , Aziz Sarah , Househ Mowafa
Published: June 2021

BACKGROUND

Background: Over the past decade, there has been a steady increase of the number of mobile and web-based applications that enable patients with mental disorders to self-regulate their mental health needs, to feel autonomous, and to take responsibility for their own care. To the best of our knowledge, no current reviews explore the features of self-care applications used for mental disorders.

OBJECTIVE

Objective: The purpose of this review is to explore the characteristics of novel mobile applications utilized for mental health self-care.

METHODS

Methods: A scoping review of literature was conducted. The search sources consisted of searching 6 electronic databases (e.g., Medline, PsychINFO) and conducting backward and forward reference list checking. Rayyan software was used for this study selection process. One reviewer checked the eligibility of the retrieved studies and extracted data from the included studies. A narrative approach was used to synthesize the extracted data.

RESULTS

Results: 2,744 citations were identified by searching the electronic databases. Of those, 15 studies were included in this review. Twelve studies used mobile applications while the remaining three studies used web-based applications. Applications in most of the included studies targeted depression (9/15, 60%). Only two types of study designs were identified from the included studies: Randomized control trials (10/15, 67%) and Usability and feasibility studies (5/15, 33%). Six studies had a sample size of less than 50 while six studies had a sample size of more than 200.

CONCLUSIONS

Conclusion: While many mobile apps have been developed to promote self-care, there is a gap in the current literature discussing the validity of such mental health resources. We were only able to identify 15 such studies from our initial search returning 2744 studies. As such, this review will ideally encourage developers to produce future, empirically reviewed apps that rise to the challenge of both being user-friendly as well as scientifically valid.
Analysis of purse seine fisheries business feasibility in coastal fishing port Pondok Dadap, Sendang Biru, East Java, Indonesia
Authors: Firdaus Imam Nurul , Prasetyo Dony , Sutarjo Ganjar Adhywirawan , Hermawan David
Published: June 2021

A purse seine is a fishing tool made of nets which are operated by circling the hordes of fish to a bowl-shaped tool at the end of the fishing process and is commonly used to catch pelagic fish by fishermen at UPT PPP Pondokdadap. The purpose of this study was to determine the technical aspects and income of the purse seine vessels in Sendang Biru village and to analyze the feasibility of the purse seine fishery business in the Sendang Biru village. This research was conducted from May to June 2019 at UPT PPP Pondokdadap, Sendang Biru, Malang Regency. The research sample was taken by purposive sampling. Data analysis using descriptive analysis and business financial analysis. The results of the calculation of the business analysis and investment on the purse seine ship found a profit of IDR 1,394,798,872, R/C of 43, PP of 13 months, ROI of 92, NPV of IDR 90,337,780,072, IRR of 633.8 %, and Net B/C is 61. The results show that the purse seine fishery business meets the requirements and is still feasible to be implemented.
Analysis of catching of sea cucumber (Stichopus variegatus) in Kramian islands, Sumenep regency, East Java
Authors: Prasetyo Dony , Hakim Riza Rahman , Andriyanto Andriyanto
Published: June 2021

Kramian Island is located in the north of the Masalembu Islands, East Java. This area has good sea cucumber resources, but the rules on the prohibition of overfishing of sea cucumbers have not been implemented by the government in the Kramian Islands, so that fishing activities carried out by fishermen, continuously regardless of the type and size of sea cucumbers, can cause sea cucumbers in the wild to run out and the impact of sea cucumbers will be extinct. The research was conducted with the aim of knowing the fishing location, fishing method, sea cucumber species, number of catches, and benefits of sea cucumber catch. This research was conducted in March-June 2020. The method used in the study was observed with fishermen. The results of the discovery of the location of sea cucumbers using GPS, there were 3 types of sea cucumbers, namely Tanduk (Stichopus variegatus), Kapuk (Stichopus variegatus), and Susu (Holothuria rigida). Sea cucumber catch in March (253.4 kg), April (261.1 kg), May (124.1 kg), June (733.6 kg). The highest sea cucumber catch data occurred in June, while the lowest catch occurred in May.
Effect of different types of feed (squid, sea worms, and trash fish) to gonad maternity and fundamental levels of Galah shrimp (Macrobrachium Rosenbergii)
Authors: Sutarjo Ganjar Adhywirawan , Hermawan David , Nisa Alvi Zahrotun
Published: June 2021

Giant prawns (Macrobrachium rosenbergii) need enough nutrients for the reproductive process. One way to give feed which contains high enough protein. Complete nutritional content, especially protein, can be found in natural food. The type of natural feed used for main feeds including squid, sea worms, trash fish. Complete nutrient content can affect the rate of gonadal development and fecundity. (Squid, sea worms, trash fish) on the level of gonadal maturity and density of broodstock parents (Macrobrachium rosenbergii). This research was conducted by a completely randomized design (CRD) trial design. This study used 4 replications of different types of feeding. The types of feed given are squid, sea worms, trash fish, and pellets at a dose of 5% from biomass/day. The parameters of observation include observation of the level of gonad resistance, fundamentality of broodstock parent, and measurement of water quality (temperature, pH, and dissolved oxygen). The results showed that the administration of different types of feed (sea worms, trash fish) had a very significant effect on the level of maturity and had a significant effect on the probability of prawns (M. rosenbergii). After analysis of variance, the results of F Calculations are greater than F Table 0.05 and F Table 0.01. The smallest significant difference test (LSD) was obtained in P1 (Squid feed) with the Gonad maturity rate ± 5- 6 days as much as 83 % parent and fecundity average results of 28,846 ± 4,925.3 thousand / 45 g.
MODIFIED FINITE-DIFFERENCE SCHEME FOR SOLVING ONE CLASS OF CONVECTION-REACTION-DIFFUSION PROBLEMS
Authors:   Anna Vladimirovna Pavelchuk Amur State University, Pavelchuk Anna Vladimirovna , Maslovskaya Anna Gennadievna ,   Anna Gennadievna Maslovskaya Amur State University
Published: June 2021

The paper reviews approaches to the construction of finite-difference methods for solving time-dependent diffusion equations and transport equations. A modified computational scheme for solving a semilinear multidimensional equation of the «reaction – diffusion – convection» type is presented. The hybrid computational scheme is based on the alternating directions method and the Robert-Weiss scheme.