bluuebunny/crossref_metadata_2025 huggingface dataset:
PENGARUH ONLINE PERSONAL BRANDING TOKOH POLITIK TERHADAP MINAT PEMILIH PEMULA
Authors: Asri Rahman , Arianti Gusmia , Mandjusri Alma
Published: August 2020

Konvergensi media saat ini telah mampu menggabungkan dan mengintergrasikan media konvensional ke dalam bentuk digitalisasi informasi, salah satunya menggunakan platform media sosial diantaranya melalui facebook dan instagram yang populer dengan jumlah pengguna terbanyak. Media sosial tidak hanya digunakan perusahaan atau brand, tapi banyak pula pihak secara individu diantaranya pejabat public yang melakukan kegiatan online personal branding  di media sosial. Ridwan Kamil dengan followers sebanyak 6 juta, seorang pejabat publik yang aktif melalui instagram untuk membentuk personal branding. Penelitian ini menganalisa pengaruh online personal branding terhadap minat pemilih pemula di Pilkada Jawa Barat 2018.
PHYSIOLOGICAL AND ENVIRONMENTAL MONITORING OF TECHNOGENIC XENOBIOTICS IN THE FOOD-ANIMAL-PRODUCTION SYSTEM
Authors: Velychko V. O.
Published: August 2020

One of the main reasons that significantly affect the functional state of the organism, animal and human health, scientists and practitioners consider the environmental state of the environment. This is primarily due to the content of toxicants, in particular heavy metals in feed grown in areas of man-made pollution, the feeding of which leads to impaired metabolism in the animal body. Certain heavy metals (Pb, Cd, Hg, As, etc.) are highly toxic and can affect the body even in very small quantities. Therefore, monitoring the toxic elements in the soil-plant-feed-animal-production-human-chain trophic chain is considered a priority area in research, under conditions of man-made loading. The works of a number of leading scientists, in particular R. Y. Kravtsiv, O. I. Razputny, I. V. Kalinin, Yu. I. Savchenko, R. Fedoruk, indicate that the ability to the accumulation of toxic elements by organisms is determined not only by the geochemistry of the environment, but also by their biological nature and the biogeochemical chain through which the connection between organisms and the environment (soil-plant-animal-human). Unfavorable ecological situation in some regions is caused by violation of requirements for chemical fertilizers, plant treatment with pesticides (herbicides, pesticides, etc.), which is especially characteristic nowadays, when large agro-industrial structures (holdings, concerns, etc.) for the cultivation of intensive crops.

The mentioned reasons include animal and poultry growth promoters, certain groups of medicines, uncontrolled industrial emissions, man-made accidents, pollution of the environment by motor vehicle emissions, etc. As a result, the compounds of Plumbum, Cadmium, Hydrargyrum, Strontium and other heavy metals also enter the atmosphere. And what is characteristic (according to literature sources) is that some of them, together with atmospheric moisture, form even more toxic compounds, which in the form of rain fall on farmland and ponds, from where they enter plants and organisms of animals and food, in particular milk and meat. That is why it is necessary to carry out physiological and environmental monitoring, respectively, and control of the migration of harmful elements in the environment, in particular, their receipt and concentration in soils, plants of food groups, feeds, animals and food. In view of this, it is especially important to improve the diets of animals fed under conditions of techno-genic loading using sorbents and their biologically active additives. Such adsorbents R. Y. Kravtsіv and coauthors, O. O. Kalinin include zeolites that have adsorbing, ion exchange, catalytic and other properties, although their use should be carried out taking into account agro-environmental conditions, as well as the forms and properties of xenobiotics, which requires research with scientific and practical substantiation.
THE ACTIVITY AND ISOFORMS OF SUPEROXIDE DISMUTASE IN TISUES OF REPRODUCTIVE ORGANS OF RATS
Authors: Kuzmina N. , Ostapiv D. , Chajkovska A. , Panych A.
Published: August 2020

The aсtivity of superoxide dismutase, the content of its isoforms in testis, epididimis, and in epididimal spermatozoa of pubescent rat males were studied. The experiments were performed on adult male rats (age 5 - 6 months). After decapitation, the testes and the epididimis were taken, from which the spermatozoa were washed with 0.9 % sodium chloride solution. The total protein and activity of superoxide dismutase (SOD) were determined in the supernatant and the sperm suspension. SOD isoforms were detected after electrophoresis in 10 % polyacrylamide gel by specific staining of gel plates with nitrosine tetrazolium. The highest activity was found to be in the tissue of the testes (18.2 ± 2.59 IU/mg of protein), less on 34.6% in the epididymis and the lowest on 46.7% in epididymal sperm. Electrophoresis in 10 % polyacrylamide gel and specific staining in the tissues of testis, epididymis, and epididymal sperm of rats revealed five major SOD isoforms, which, depending on the speed of movement in PAAG, were labeled, from maximum to least mobile, such as S1, S2, S3, S4 and S5. The specifity of testicular tissue is the presence of two minor isoforms (S1a- and S1b-isoforms), which are characterized by high electrophoretic mobility and lower intensity of manifestation, and the color disappears over time, unlike other proteins of the enzyme. It was found that the SOD isoenzyme spectrum is characterized by tissue specificity and depended on the physiological and functional features of the tissue of the reproductive organs of males and spermatozoa. In the testis tissue, S2 isoform was in the largest amount– 36.7 ± 1.91%, less and almost the same content of S1-, S3- and S4-isoforms (18.0 ± 3.27, 19.3 ± 3.98 and 15.7 ± 2.15%) and the least – S5-, S1a- and S1b-isoform (6.2 ± 1.20%; 2.2 ± 0.03 and 1.9 ± 0.01%). In the epididimis tissue, the content of the S3-isoform was higher on 17.9% and S2- and S1- respectively on 7.9% and 4.9%, respectively, compared to the testis. SOD isoenzymes of epididymal spermatozoa are characterized by a high content of S2 isoforms, which is more on 11.2% than in the testis, and the content of S1 isoforms, by contrast, is lower on 10.0%. The established differences in the content and activity of individual isoforms of the enzyme indicate the existence of tissue specificity of SOD proteins, due to the functional characteristics of the studied tissues. Optimal protection of sperm from O2• - in the process of their differentiation and maturation is ensured by the activity of different SOD isoforms, confirming the established differences in the isoenzyme spectrum.
QUALITY INDICATORS OF EGGS OF LOHMANN BROWN AND LOHMANN SANDY CROSSBREEDS
Authors: Romanyk H. M. , Fedorovych V. V.
Published: August 2020

The paper presents the results of researches of the chemical and morphological composition of eggs of chicken crossbreeds Lohmann Brown and Lohmann Sandy. It was established that the chemical composition of egg yolks depended on the specific crossbreed and age of chickens. The chemical composition of the egg yolk of Lohmann Brown crossbreed mainly prevailed over the chemical composition of the egg yolk of Lohmann Sandy chickens of the same age, however this difference was mostly doubtful. The most relevant difference in the age of 21 weeks was in the content of the fat (0,16 % when Р<0,005), in the age of 49 weeks – in the content of the dry matter and ash (0,69% and 0,06 % respectively when Р<0,001 in both cases), in the age of 71 weeks – in the content of the protein and ach (0.18% (Р<0,01) and 0,24 % (Р<0,001) respectively).

With aging of chickens, the most of the researched indicators of eggs of Lohmann Brown crossbreed underwent fluctuant changes, and only the content of the raw fat in the yolk decreased. At the same time, the eggs of Lohmann Sandy chickens of the same age demonstrated a lowering content of raw protein, raw fat and raw ash, while changes of the content of the dry matter had a fluctuant character. At the same time, with aging of both crossbreeds we observed the highly probable increase in the weight, length and width of eggs, the weight of the yolk, white and shell, while the thickness of the shell on the blunt end decreased with every next age period. The majority of morphological indicators of eggs of Lohmann Brown crossbreed exceeded the similar indicators of eggs of Lohmann Sandy chickens of the same age.

This prevalence in the egg weight depending on the age period ranged from 6,81 to 7,95 grams, in the egg length – from 1,1 to 3,0 mm, in the egg width – from 1,6 to 1,8 mm, in the yolk weight – from 2,2 to 2,55 grams, in the egg white weight – from 3,83 to 4,44 grams. The concentration of hydrogen ions (pH) of the egg yolk and white depending on the age period and crossbreed of chicken ranged within 6,28-6,43 and 8,11-8,21 respectively, that corresponds to the permissible levels. The difference of the first indicator for birds of different crossbreeds was statistically reliable (P<0,001) and constituted 0,02-0,05 depending on the age period, while the difference in indicators related to the egg white was doubtful and comprised 0,02-0,13. The energy value of eggs of both controllable crossbreeds was almost equal, with the highly probable difference in the age of 21 weeks and 77 weeks.
ETHOLOGICAL REACTIONS IN F2 WEANING FEMALE AND MALE RATS INFLUENCED BY DIFFERENT DOSES OF GERMANIUM CITRATE
Authors: Tesarivska U.
Published: August 2020

The paper considers the condition of emotional and behavioral responses on growth and development of 40-days F2 rats, while weaning them from their mothers, by the exposure of 10, 20 and 200 mcg Ge / kg b.w. doses of Germanium (Ge) citrate. Behavioral characteristics and emotionality were assessed using an «open-field» test, which is widely used in modern neurophysiological experiment. The results of the studies indicate that the animals, which used to drink Germanium citrate, noted a smaller, overall intensity of locomotion, except for males which were given 10 μg Ge/kg b.w., in relation to control group, which may indicate an increased anxiety of animals in an unusual environment caused by exposure to Germanium citrate. The results of the orienting research reaction, determined by the “hole-to-open” test, indicate that both sexes animals, which were exposed by 10 μg Ge / kg b.w., noted the increasing of their activity. When exposed to 20 μg Ge / kg b.w., a decrease in the above mentioned indicator was observed. During the exposure of the highest dose of Germanium citrate, 200 mcg Ge/kg bw, the females reacted with a slight increase, and males with a decrease in cognitive activity. Therefore, the study of the orientational research activity of animals indicates about dose-depended and inter-sex differences in the level of the «hole» reflex. When exposed by 10 μg Ge/kg b.w., animals of all research groups, except males, noted lower level and duration of grooming, compared with the indices of the intact animals. This cosmetic behavior, as a factor of emotionality, is sensitive to stress and various pharmacological manipulations. As for retioning, this index was higher than control in both sexes animals, which were exposed with 20 and 200 μg Ge/kg b. w., except the animals which were given the lowest concentration (10 μg Ge/kg b.w.) Ge citrate. The results of the clambing study, as another test of the rat's motor and research activity, indicate that females of all study groups and males, when they were exposed to 10 and 200 μg Ge/kg b. w., observed the higher its level, than that of the intact animals. Therefore, in most animals the use of Germanium citrate results the higher level of vertical activity. When using different doses of Germanium citrate, in females less or equal to the control number of boluses were noted, but males observed quite noticeable increase of this index which was although statistically incredible. A high level of bowel movements indicates an excessively high emotionality of the animal. During testing no abnormal movements were observed in both sexes animals, and both control and experimental groups.
Deficiencia congénita del factor VII de la coagulación: relato de casos de una institución de atención ambulatoria
Authors: Brandenburg Thaís Byanca , Andrade Reginaldo Jose , Michels De Oliveira Antônio Carlos , Schossler Loss Francisco
Published: August 2020

Introducción. La deficiencia del factor VII (FVII) de la coagulación es una coagulopatía hereditaria rara que presenta amplia diversidad genética y manifestaciones hemorrágicas de grado variable, desde situaciones asintomáticas hasta episodios hemorrágicos potencialmente letales. El diagnóstico se realiza por exámenes de laboratorio de una muestra de sangre con pruebas de rutina y dosificación del factor. El tratamiento se determina de acuerdo con la correlación entre la dosificación del factor y las manifestaciones hemorrágicas de la enfermedad. Objetivo. Elestudio abordó la revisión de los casos de deficiencia del FVII, abarcó aspectos clínicos, diagnósticos y terapéuticos de la enfermedad. Material y Métodos. Casos de pacientes que fueron reportados con deficiencia congénita del FVII en un ambulatorio. El estudio fue realizado con una revisión de los prontuarios de seis pacientes, registrados en el Hemepar en Cascavel/Paraná. Se realizó un análisis de la literatura basada en artículos de la base de datos PubMed y Scielo, así como el Manual de Coagulopatías Raras del Protocolo del Ministerio de Salud Brasileña. Investigación sometida y aprobada por el Comité de Ética en Investigación con Seres Humanos de la Fundación Asís Gurgacz portando CAAE 90617418.3.0000.5219. Resultados. De los seis pacientes, cinco pacientes presentaron FVII mayor de 20 % y uno, FVII menor de 1 %; cuatro no tenían antecedentes de sangrado previo, tres no tenían historia familiar de la enfermedad y cinco recibieron reposición de FVII. Conclusión. Este estudio mostró la importancia de realizar una investigación completa del paciente e individualizó cada caso para evaluar la real necesidad de reposición del FVII y evitar su desperdicio.
Síndrome de Sweet en un paciente infectado con el VIH
Authors: Pachas Quiroz Alessandra Ynes , Chian García César , Villarreal Menchola Juan
Published: August 2020

El síndrome de Sweet (SS) fue descrito por primera vez por Robert Douglas Sweet, en 1964, tras observar a ocho pacientes mujeres en el Hospital General de Plymouth. Entre 1949 y 1964 se describieron las cuatro características fundamentales para el diagnóstico de la enfermedad: fiebre; leucocitosis neutrofílica; erupción aguda en forma de placas y/o nódulos eritematosos y edematosos generalizados; infiltrado neutrofílicodérmico masivo sin vasculitis. El SS se ha descrito en todo el mundo sin predilección racial y es caracterizado por la aparición abrupta de fiebre, neutrofilia, lesiones eritematoso cutáneas e, histológicamente, por un infiltrado difuso de neutrófilos ubicado en la dermis superior.
Tuberculosis pericárdica con efusión hemorrágica
Authors: Herrera Valdivia Raúl , Rojas Contreras Christian , De la Cruz Yaya Eduardo , Florián Molina Mery
Published: August 2020

Se presenta el caso de un paciente varón de 19 años con tres semanas de enfermedad, fiebre, diaforesis, tos, pérdida de peso, disnea progresiva. Llegó al servicio de Emergencia con síntomas de insuficiencia cardiaca. Los estudios demostraron derrame pericárdico moderado. Se realizó una ventana pericárdica donde se evidenció liquido pericárdico hemorrágico. El estudio histológico del pericardio y de un ganglio mediastínico reveló uninfiltrado crónico granulomatoso y caseificante, sugerente de tuberculosis pericárdica. Respondió favorablemente al tratamiento antituberculoso más prednisona.
OPERATIONAL PERFORMANCE OF KINFRA INDUSTRIAL PARKS IN KERALA: SELECT INFERENCES
Authors: Dr. P. Noufal
Published: August 2020

Kerala aims to become one of the top 10 ranking States in the country in terms of ease of doing business and in promotion of a typical business and entrepreneurial culture at par with global standards. Being an active facilitator and industrial catalyst of the State, the Kerala Industrial Infrastructure Development Corporation (KINFRA) has a saga of success in making Kerala as one of the most promising and vibrant business cynosure with leading-edge infrastructure. The industrial parks set up by KINFRA are today recognised as important instruments for promoting rapid industrial development, innovation, competitiveness, productivity and focused growth of the regional economy of the State. It is in the context, the paper attempts to explore the operational performance of KINFRA industrial parks within the ambit of the extent of realisation of its objectives.

KEYWORDS: Kerala Industry, Industrial Development, Industrial Parks, Operational Efficiency, KINFRA.
TINGKAT KEPUASAN KONSUMEN TERHADAP ATRIBUT BUAH PEPAYA DI PASAR TRADISIONAL KOTA SURAKARTA
Authors: M.Th. Handayani  , Ratih Dwi Kartikasari  , Nur Husnina Fatin
Published: August 2020

This study aims to determine the level of satisfaction of consumers towards the attributes of papaya in the traditional market of Surakarya City. Data is processed using the CSI (Customer Satisfaction Index) method. The study was conducted from January to March 2020 in Surakarta City with 100 consumers as respondents. CSI analysis is used to measure the level of customer satisfaction through the calculation of consumer ratings of the attributes of indicators attached to an item. The results of the study based on CSI values indicate that the results of consumer satisfaction in traditional markets are classified as satisfied (80,59%). The order of consumer satisfaction with the attributes of papaya in traditional markets is the variable taste, size, level of maturity and price. Consumers are satisfied because the expectations in buying for papaya in traditional markets in the city of Surakarta have been fulfilled.
Osterwa po wojnie albo Pięknosłużca w Polsce Ludowej
Authors: Cymerman Jarosław
Published: August 2020

Artykuł jest poświęcony działalności Juliusza Osterwy po II wojnie światowej, w latach 1944–1947. Autor charakteryzuje społeczną i artystyczną postawę Osterwy wobec nowej rzeczywistości i przypomina rolę, jaką odegrał on w odbudowywaniu polskiego teatru po wojnie. Rysuje także obraz jego skomplikowanych relacji z komunistyczną władzą, pokazując, że wymykają się one jednoznacznym klasyfikacjom i ocenom. Tekst koncentruje się w głównej mierze na przedstawieniach zrealizowanych w tym czasie przez twórcę Reduty: Uciekła mi przepióreczka Stefana Żeromskiego (1945) w Krakowie, Fantazy Juliusza Słowackiego (1945) w Łodzi, Lilla Weneda Słowackiego (1946) i Papuga Kazimierza Korcellego (1946) w Warszawie, wreszcie Fantazy w Krakowie (1946) z ostatnią rolą Osterwy. Na podstawie prasowej recepcji tych spektakli tworzy obraz nadziei i napięć towarzyszących powojennej działalności wybitnego aktora, reżysera i pedagoga w ostatnich latach jego życia. Wspomina także o niezrealizowanych pomysłach, których śmiertelnie chory Osterwa nie zdołał urzeczywistnić.
«Samarski smutek» Osterwy
Authors: Lappo Irina
Published: August 2020

Artykuł jest próbą interpretacji znaczenia pobytu Juliusza Osterwy w Samarze (lipiec 1915–luty 1916) w procesie jego artystycznego rozwoju. Podstawę interpretacji stanowi literatura dokumentu osobistego: Zeszyt samarski i list do Makuszyńskiego z 1915 oraz wspomnienia artysty z lat trzydziestych. Obraz samarskiego życia Osterwy uzupełniają prace rosyjskich historyków rekonstruujących losy polskich uchodźców podczas I wojny światowej. Konfrontacja obrazu Samary wyłaniającego się z prac historycznych z obrazem nakreślonym w zapiskach Osterwy umożliwia ukazanie mechanizmu przesłaniania bolesnych doświadczeń konstrukcjami mentalnymi w autonarracjach artysty. W artykule postawiono hipotezę, że pobyt w Samarze wiązał się z poważnym kryzysem egzystencjalnym przezwyciężonym w grudniu 1915 dzięki zrealizowanemu razem z Drabikiem widowisku jasełkowemu. „Samarski smutek” pozwolił Osterwie zdobyć się na dystans wobec własnego statusu gwiazdy. Zderzenie z obcością wyostrzyło świadomość kulturową i uruchomiło nową perspektywę widzenia. Bożonarodzeniowe przedstawienie pomogło lepiej zrozumieć społeczną funkcję teatru jako miejsca przezwyciężania kryzysu tożsamościowego.
In Service of the Living Word: Some Thoughts on «Reducie na stulecie: studia i rozpoznania»
Authors: Salata Kris
Published: August 2020

Conceived as a symbolic gift to honor Teatr Reduta on the 100th anniversary of its inception and dedicated to the memory of recently passed theatre historian, Zbigniew Osinski, this extensive volume does more than commemorate and celebrate. It advances the studies of one of the most original and deeply influential undertakings in Polish theatre, which, despite securing its emblematic place in histry, deserves a closer analysis from the contemporary perspective, and further dissemination among scholars and practitioners. Reading the book from across the Atlantic Ocean, I will add, that this need for continued rethinking of theatre in dialogue with Osterwa and Limanowski in current Polish cultural and political context seems to be as important as challenging. On the one hand, religious and spiritual underpinnings of Reduta may be particularly susceptive to “committed” interpretations, to use Adorno’s term. On the other hand, memories bring the threat of nostalgia and sentimentalism which help to mythologize rather than analyze unique phenomena. Has Reducie na stulecie managed to stay free from these historiographic traps? What value do these history lessons bring to us today
CRIAÇÃO DE UM INSTRUMENTO PARA CLASSIFICAÇÃO DE RISCO DE ABANDONO NO TRATAMENTO DA TUBERCULOSE
Authors: De Souza Correa Ana Clara , Carneiro Flor Sandra Maria , Do Carmo Leão Maria Cecília , Moreira Fontenele Júnior Antônio Ademar , Siqueira Lima Freitas Cibelly Aliny , De Araújo Dias Maria Socorro
Published: August 2020

O estudo tem como objetivo relatar a experiência da criação de uma ficha de classificação de risco de abandono de pacientes diagnosticados com tuberculose (TB). Trata-se de um estudo descritivo, do tipo relato de experiência, desenvolvido pela Célula de Vigilância Epidemiológica do Município de Sobral. A ação foi realizada em agosto de 2017, no auditório da Unidade de Vigilância em Zoonoses. A intervenção teve como objetivo discutir os casos de abandono no tratamento de tuberculose, através de estudos de casos apresentado por profissionais da saúde dos Centros de Saúde da Família que tiverem casos de abandono, para assim obter subsídios que ajudassem na prevenção desses casos. Com a criação e aaplicação do instrumento foi possível identificar um declínio nos casos de abandono de TB, uma vez que proporcionou um maior acompanhamento pela equipe de saúde. As variáveis avaliadas permitem aos profissionais analisar o cenário no qual os pacientes se encontram e, com isso, possibilitam uma intervenção de forma efetiva por parte da equipe multidisciplinar. Dessa forma, é possível minimizar os riscos de abandono do tratamento e interromper a cadeia detransmissão.
Language Choice Among Commuter Bus Conductors (Drivers' Mates) and Passengers at Kumasi Kejetia Bus Terminal, Ghana
Authors: Isaac Oduro  , Mercy Asantewaa  , Olivia Donkor  , Francis Kwadwo Kusi  , Wilson Oduro  , Felicia  Asamoah-Poku
Published: August 2020

This research aims to examine the language used by the commuter bus conductors and passengers moving to and from Kejetia bus terminal in the Kumasi Metropolis, Ghana. This research basically focuses on sociolinguistics approach. The source of the data is purely the utterances of the bus conductors and the passengers on board in the commuter buses. Observation and recording were used as the data collection instruments in the study. Both qualitative and quantitative methods were used to analyze the data gathered. The study found Asante Twi dialect as the most dominant language choice of the majority of the sampled population (passengers and drivers' mates). The use of unmarked code switching in conversational discourse was not uncommon among participants. Finally, the study found English language to be the second most dominant language choice in the participants' verbal discourse. The implication is that apart from Akan language, all the other seven languages stand the risk of experiencing language shift leading to eventual language death should the ethnic groups concerned fail to maintain their languages.
Development and Antimicrobial Evaluation of Binary Ethosomal Topical Gel of Terbinafine Hydrochloride for the Treatment of Onychomycosis
Authors: V Kishan , K Shruthi , D Narendar , N Arjun
Published: August 2020

The objective of this investigation was to prepare and evaluate the binary ethosomal gel containing terbinafine HCl (TH) to treat onychomycosis. It was reported that binary ethosomes possessed good permeation and stability characteristics than ethosomes. Binary ethosomes of TH were prepared by film hydration method. Prepared binary ethosomes were evaluated for optimized system. Further, ex-vivo skin permeation studies were conducted with rat skin. The formulation of binary ethosomes was converted to gel by using carbopol 934 and evaluated for rheological properties. Antifungal testing of gel was done by cup plate method, using Candida albicans and zones of inhibition of growth were measured. The size, ZP and EE of the prepared binary ethosomes ranged from 200-320nm, -20 to -30mV and 70-92% respectively. In-vitro and ex-vivo diffusion studies indicated that formulation BE4 with greater amount of binary alcoholic phase, showed faster release and increased flux over others. SEM studies revealed that binary ethosomes were in spherical shape. Based on size, EE, drug release profile and antifungal studies, the BE4 formulation was selected for gel preparation. The prepared 0.5% binary ethosomal BE4 gel showed good content uniformity, pH 5.5, no skin irritation, good consistency and better rheological behaviour. Further, antifungal studies of BE4 gel indicated that gel had lower antifungal activity than plain BE4 formulation, probably due to gelling effect in agar diffusion studies. In conclusion, we developed a pharmaceutical gel containing binary ethosomes of BE4 having TH to provide anti-fungal effects useful for the treatment of onychomycosis.
Terpenoids from Dicliptera chinensis (L.) Nees Grown in Vietnam and their Anti-inflammatory Activities
Authors: Duc Loi Vu , Thanh Tung Bui , Huu Tung Nguyen
Published: August 2020

The main goal of this study was to isolate and screen the therapeutic potential of some terpenoids from Dicliptera chinensis (L.) Nees grown in Vietnam. From the leaves of Dicliptera chinensis (L.) Nees (Acanthaceae) collected in Nam Dinh province, one new terpenoid (1) together with five known (2-6) were isolated by chromatographic methods. These compounds were identified as 6-hydroxy-1,12-oleanadien-3-on (1), 1β,4β-dihydroxyeudesm-11-ene (2), 3β-hydroxylup-20(29)-en (3), stigmast-5,22-dien-3-β-ol (4), rutaevine (5), mangiferin (6). All of them were isolated from this plant for the first time. Compound 4 showed signficant potential for COX-2 inhibitory effects with IC50 values of 7.32± 1.82 µg/mL. These pilot results suggest the potential of Dicliptera terpenoids for treating inflamatory conditions.
Proteus penneri Assisted Synthesis of Metal Nanoparticles: Biofunctional Evaluation and Characterization
Authors: S Satish , H. P. Spoorthy , H B Vasanth Patil , N D Rekha
Published: August 2020

The metal nanoparticles synthesized by green synthesis can be used as an alternative strategy to overcome antimicrobial resistance. In this study, metal nanoparticles were synthesized using Proteus penneri, a Gram-negative rod-shaped bacteria that facilitated the reduction of metals into their respective nanoparticles. Biosynthesized particles were characterized by DLS, SEM, UV-visible spectroscopy. It was selected for the study and was found to have the ability to form silver, gold, chromium, copper, nickel and zinc nanoparticles as observed by change in color of the reaction. The spectral analysis confirmed the presence of carbonyl groups from the amino acid residues wherein proteins have the stronger capability to bind the metal that probably aid in the formation of metal nanoparticles. Antibacterial property reveals that silver, gold and chromium based metal nanoparticle are best suitable candidates to overcome antibiotic resistance. Zn and Au showed significant anti-inflammatory property by inhibiting PLA2, further they could inhibit angiogenesis there by exhibiting anti cancerous property
Development, Solubility Enhancement and Characterization of Nimodipine Solid Dispersions
Authors: D. V. R. N. Bhikshapathi , G Muralichand
Published: August 2020

The main aim of this study was to formulate and characterize nimodipine solid dispersions using various novel polymers. Solid dispersions were prepared by solvent evaporation method in order to improve the solubility and overall bioavailability of nimodipine. Solubility and dissolution studies indicate that Kolliwax RH 40 is the most suitable polymer. The solubility studies was corresponded with dissolution data and the formulation SD15 was found to be having highest drug release of about 98.96 ± 5.15% in about 90 minutes. In vitro release data from several formulations containing Nimodipine was determined kinetically using different mathematical models like Zero order, First order, Higuchi, and Korsmeyer–Peppas model. XRD and SEM studies indicate no crystallinity in the optimized formulation SD15. FTIR studies suggested good drug excipient compatibility between all components of prepared formulation. These results confirm the viability of enhancing the solubility of nimodipine by formulating the drug as solid dispersions in Kolliwax.
Metallic Nanoparticle Synthesis by Green Chemistry
Authors: Sood Anikate , Agarwal Shweta
Published: August 2020

Nanotechnology is the most sought field in biomedical research. Metallic nanoparticles have wide applications in the medical field and have gained the attention of various researchers for advanced research for their application in pharmaceutical field. A variety of metallic nanoparticles like gold, silver, platinum, palladium, copper and zinc have been developed so far. There are different methods to synthesize metallic nanoparticles like chemical, physical, and green synthesis methods. Chemical and physical approaches suffer from certain drawbacks whereas green synthesis is emerging as a nontoxic and eco-friendly approach in production of metallic nanoparticles. Green synthesis is further divided into different approaches like synthesis via bacteria, fungi, algae, and plants. These approaches have their own advantages and disadvantages. In this article, we have described various metallic nanoparticles, different modes of green synthesis and brief description about different metabolites present in plant that act as reducing agents in green synthesis of metallic nanoparticles.
Nanoneedle Mediated Delivery of Silver for Topical Therapies
Authors: B.S. Wakure , Bhatia N.M.
Published: August 2020

We explored the nanoneedles− a novel nanostructured material (NSM) fabricated by nanofabrication techniques and assessed their suitability as a carrier for delivery of silver drug cargo. We achieved individual nanoneedles with tip diameter of 220-250 nm, desired micro-scale length, high Young’s modulus (~100 GPa), and large external surfaces. Owing to large external surfaces of nanoneedles compared to micro-carriers utilized to deliver cargo of drug substances for topical drug delivery. Drug molecules were conjugated on nanoneedle surface and then released by means of predesigned surface chemistry. SEM, TEM, FTIR, XRD and TGA confirmed surface morphologies, structure of nanoneedles. SQUID magneto-meter was used to ascertain the magnetic behavior of nanoneedles. In vivo methods were carried out to assess wound healing potential of Silver Chitosan nanoneedle, wherein it shows the better results for wound healing. Thus, it could provide better scaffold for wound healing in near future.
Review of Atypical Lipoma and its Natural Treatment
Authors: Dasvani, Brijesh , Khristi Avani , Thiyagarajan Vanniyer
Published: August 2020

Atypical lipomatous are rare tumors that typically arise out of soft tissues in the body and common in adults. Most lipomas comprise of mature fat cells that exhibit characteristic of benign tumor by nature. They are round, motile, non-painful slow growing masses, with a characteristic soft and soggy feel, usually appear in the hypodermic area of skin. Atypical lipomas, though uncommon and slow growing can be associated with syndromes such as multiple hereditary lipomatosis, colorless adipose, Gardner's syndrome and Madelung's disease. While surgery has been the primary treatment modality, doctors have managed few patients with radiation therapy (RT). Median age of diagnosis was found in the range: 36–76 years but intramuscular lipomas may occur irrespective of age group, right from childhood to old age. However, the occurrence dominancy was found between the ages of 42 and 72 years, with the average age at presentation reported as 47 to 57 years.
Nano Sponges
Authors: Salunke Amarjit Salunke , Upamanyu Neeraj , Singh Alka , Jaiswal Ashish
Published: August 2020

The convenient and recent drug delivery system always likely to have some ideal and unique characters, particularly for safety, desired actions, accurate delivery, enrich with a therapeutic index with minimal adverse occurrence. In this regard, Nano sponges serve as a recent advance new drug delivery. Many researchers are attracted and concerned on Nano sponges presently. The present twofold objective of the review clarifies why Nano sponges are recent and advanced delivery system along with challenges related to solubility, stability and controlled release of Nano sponge and proven techniques to overcome. Since the nano-sized drug free carriers are recently formulated and suggested for drug delivery, which can be loaded with the numerous drugs, hence dealing with an appropriate technique for drug release is the need of the present time. This article states the most convenient method for drug release, and at concluding part gives awareness on recent work done and result obtained on Nano sponge worldwide along with the unique summary on the US granted patents for Nano sponges. Thus, a complete scenario on recent work, methods for evaluations, unique and multiple characters of Nano sponge has been discussed and summarized.
Green Synthesis of Silver Nanoparticles Using Olden-landia corymbosa and Ocimum sanctum Leaf Aqueous Extract
Authors: Chatterjee Prof.(Dr.) Sirshendu Chatterjee , Das Shaktijit , Saha Moumita , Ghosh Pranabesh , Sengupta Titav , Nandi Subhadra , Kulavi Sohini , Mandal Suprodip
Published: August 2020

The field of nanotechnology is the most renowned area of research in modern day science. One of the most convenient and comprehensive technique related to the synthesis of nanoparticles using plant extracts and their subsequent action. On the other hand, herbal medicines become an integral part of modern-day treatment strategy around the globe; combination of these two ways are widely accepted and beneficial due to its low cost, better societal recognition and less side effects. Phytochemical analysis revealed that leaf aqueous extract of two medicinal plants Oldenlandia corymbosa and Ocimum sanctum, harbours high concentration of antioxidants and bioactive molecules. Hence our present course of study aims at the green synthesis of silver nano-conjugates using Oldenlandia corymbosa and Ocimum sanctum leaf aqueous extracts. The synthesized nano-conjugates have undergone advanced chara-cterization techniques including UV-Vis Spectro-photometry, DLS, and FT-IR. The UV-Vis spectroscopy results showed single peak at 420 nm and 430 nm for Oldenlandia corymbosa and Ocimum sanctum nano-conjugates, respectively. The particle size for Oldenlandia corymbosa and Ocimum sanctum nano-particles are 21.04 nm and 24.36 nm, respectively as observed from the DLS data, and finally, the FT-IR data confirms the conjugation of bioactive molecules of the medicinal plants indicating that primary amines, secondary amines, alcohols, phenols, aldehydes, aliphatic amines, alkenes, functional groups of the bioactive molecules are responsible for the stability of prepared silver nano-conjugates
Tinjauan Teoritis Efektivitas Pemeriksaan Pajak Di Indonesia
Authors: Lim Setiadi Alim , Indrawati Lilik
Published: August 2020

Each country can use a tax collection system that varies between countries. Basically, each country can choose one of the tax collection systems, namely between the official assessment system or the self assessment system. On the official assessment system the amount of tax payable and must be paid by the taxpayer is determined by the tax authority. Whereas in the self assessment system the amount of tax payable and must be paid will be calculated, deposited and reported by the taxpayer himself. Most countries in the world use the self assessment system. A country that applies the self assessment system will usually experience problems related to the low level of tax compliance. To increase the level of taxpayer compliance, countries that implement the self assessment system must routinely carry out tax audit actions to test the compliance of taxpayers. In

order for the purpose of the tax audit to be achieved, the tax audit must be carried out effectively. Indicators that are usually used to assess the effectiveness of tax audits are compliance from taxpayers. The effectiveness of tax audits is also influenced by several factors that can generally be summarized into 7, namely: organization, organizational independence, taxpayer, tax audit quality, tax auditor, regulation, and management support. This research is intended to see whether the tax audit in Indonesia has been running effectively. The effectiveness of tax audits is evaluated by looking at whether the factors that influence the effectiveness of the tax audit have been included in the tax audit in Indonesia. This research is a library research with a statute approach, conceptual approach, and comparative approach. The results of the study show that from the evaluation of all factors that might influence the effectiveness of tax audits, organizational factors, tax auditors, regulations, and management support from the Directorate General of Taxation have met the criteria for the realization of effective tax audits in Indonesia. But the taxpayer factor, the independence of the organization and the tax audit quality have not supported the realization of an effective tax audit. Then when viewed from the level of taxpayer compliance as an indicator that shows that tax audits have been carried out effectively, tax audits in Indonesia have not been effective, because the level of compliance from taxpayers is only at 62.96% for corporate taxpayers and non-individual taxpayers employees and Compliance Ratio Submission of Annual Income Tax Returns in 2017 only reached 72.64%.
Apakah Keputusan Pembelian Konsumen Java Origin Terkait Dengan Pemasaran Produk Online?
Authors: Dewi Liliana , Wiryono Liem Evan
Published: August 2020

Java Origin is a company that produces batik shirts in modern design by using mixing cloth and denim fabric.  This study aims to determine the influence of online media and personal selling of people in this research to know the purchasing decisions of Java Origin consumers. Determination of source data used samples saturated with 77 respondents, that is consumers who have purchased Java Origin products. The method in this research is a quantitative method. This data retrieval method uses a questionnaire that is distributed directly by using multiple linear regression as a data analysis technique. The result of this research is the online media and personal sale variable influence significant to a decision of purchasing Java Origin.
Entrepreneurial Intention Ditinjau Dari Entrepreneurial Motivation Dan Education Mahasiswa Manajemen Universitas Ciputra
Authors: Tali Feilany , Dewi Liliana
Published: August 2020

The purpose of this research is to know the influence of Entrepreneurial Motivation and  Entrepreneurship Education toward Entrepreneurial Intention on Faculty of Business Management, Ciputra University. The sample were used 93 students. This research used a quantitative research, random sampling and data was collect by questionnaire. The analysis technique used correlation pearson, cronbach alpha, multiple linear regression, t test, F test, and classical assumptions test. The result of multiple linear regression analysis is Ŷ = 0,750 + 0,585X1 + 0,240 X2, that means entrepreneurial intention influenced by entrepreneurial motivation and entrepreneurship education. Based on the results of study, it was found: 1) entrepreneurial motivation have positive and significant impact on entrepreneurial intention; based on multiple linear regression analysis (t test), is known tcount> ttable (5.331> 1.818) and the significance value <0.05(0,000). 2) entrepreneurship education have positive and significant impact on entrepreneurial intention; based on multiple linear regression analysis (t test), is known tcount> ttable (3,077 > 1,818) and the significance value <0.05 (0,003). 3) entrepreneurial motivation and entrepreneurship education together have a strong influence and direction of entrepreneurial intention (44.6%), while 54.4% are influenced by other variables not examined by researcher.
Tinjauan Sistem Informasi Akuntansi UMKM Berbasis Cloud
Authors: Prilahardo Rahadian
Published: August 2020

The purpose of this study is to identify considerations of acquiring Cloud based Accounting Information System as Software as a Service (SaaS) towards small to medium businesses which has evolve alongside information technology revolution by comprehensively review basic concept of cloud computing and flexibility and agility values added by cloud computing onto conventional Accounting Information System thus may change the decision making process for small to medium business owners and management. This study provides comprehensive review of Cloud-based Accounting Information System and Non-cloud for small and medium business.
Face Perception and Narcissism: Variations of Event-Related Potential Components (P1 & N170) with Admiration and Rivalry
Authors: Mück Markus , Ohmann Katharina , Dummel Sebastian , Mattes André , Thesing Ulrike , Stahl Jutta
Published: August 2020

Previous studies have demonstrated that highly narcissistic individuals perceive themselves as grandiose and devaluate and sometimes overvalue others. These results are mainly based on behavioural data, but we still know little about the neural correlates underlying, such as perceptional processes. To this end, we investigated event-related potential components (ERP) of visual face processing (P1 and N170) and their variations with narcissism. Participants (N = 59) completed the Narcissistic Admiration and Rivalry Questionnaire and were shown pictures of their own face, a celebrity’s face, and a stranger’s face. Variations of P1 and N170 with Admiration and Rivalry were analysed using multilevel models. Results revealed moderating effects of both narcissism dimensions on the ERP components of interest. Participants with eitherhighAdmiration orlowRivalry scores showed a lower P1 amplitude when viewing their own face compared with when viewing a celebrity’s face. Moreover, the Self-Stranger difference in the N170 component (higher N170 amplitude in the Self condition) was larger for higher Rivalry scores. The findings showed, for the first time, variations of both narcissism dimensions with ERPs of early face processing. We related these effects to processes of attentional selection, an expectancy-driven perception, and the mobilisation of defensive systems. The results demonstrated that by linking self-report instruments to P1 and N170, and possibly to other ERP components, we might better understand self- and other-perception in narcissism.
Automated high-content imaging for cellular uptake, from the Schmuck cation to the latest cyclic oligochalcogenides
Authors: Martinent Rémi , López-Andarias Javier , Moreau Dimitri , Cheng Yangyang , Sakai Naomi , Matile Stefan
Published: August 2020

Recent progress with chemistry tools to deliver into living cells has seen a shift of attention from counterion-mediated uptake of cell-penetrating peptides (CPPs) and their mimics, particularly the Schmuck cation, toward thiol-mediated uptake with cell-penetrating poly(disulfide)s (CPDs) and cyclic oligochalcogenides (COCs), here exemplified by asparagusic acid. A persistent challenge in this evolution is the simultaneous and quantitative detection of cytosolic delivery and cytotoxicity in a high-throughput format. Here, we show that the combination of the HaloTag-based chloroalkane penetration assay (CAPA) with automated high-content (HC) microscopy can satisfy this need. The automated imaging of thousands of cells per condition in multiwell plates allows us to obtain quantitative data on not only the fluorescence intensity but also on the localization in a very short time. Quantitative and statistically relevant results can be obtained from dose–response curves of the targeted delivery to selected cells and the cytotoxicity in the same experiment, even with poorly optimized cellular systems.
Micronúcleos en reticulocitos de ratones Balb/c tratados de forma oral con nanopartículas de plata
Authors: Castañeda-Yslas Idalia Yazmin , Ruiz-Ruiz Balam , Arellano-García María Evarista , Juárez-Moreno Karla Oyuki , Torres-Bugarín Olivia , Bogdanchikova Nina , Pestryakov Alexey , Radilla-Chávez Patricia
Published: August 2020

El estudio de la genotoxicidad en modelos murinos es útil para responder las dudas relacionadas con la seguridad por el uso de nanomateriales, sobre todo cuando se pretende el desarrollo de nuevas opciones terapéuticas.  El propósito de este trabajo fue evaluar la capacidad genotóxica de AgNPs Argovit™ a partir de la técnica de micronúcleos en reticulocitos de sangre periférica de ratones, prueba ampliamente utilizada para conocer el potencial genotóxico de diferentes agentes. Las nanopartículas de plata se suministraron en dosis terapéuticas por vía oral (indicadas para perros como tratamiento para el moquillo) durante tres días a un grupo conformado por siete ratones y a otros dos grupos con igual número de ratones se administró respectivamente agua inyectable y arabinosa C. Los especímenes fueron medidos, pesados antes y después del experimento. También se tomaron diariamente muestras de sangre periférica mediante un corte en la punta de la cola para posteriormente realizar extendidos sobre portaobjetos para la prueba de micronúcleos en reticulocitos. Los frotis se fijaron en etanol al 80 % y se tiñeron con anaranjado de acridina para posteriormente leer en 1000 reticulocitos la presencia de micronúcleos con microscopio de fluorescencia. Los resultados preliminares muestran diferencias significativas en el número de micronúcleos en reticulocitos entre los tres grupos, por lo que se requiere comprobar este resultado con otro tipo de modelos in vitro.