bluuebunny/crossref_metadata_2025 huggingface dataset:
Research on optimal operation of cascade pumping stations based on an improved sparrow search algorithm
Authors: Wang Xueni , Ma Xiamin , Liu Xiaolian , Zhang Leike , Tian Yu , Ye Chen
Published: September 2023

For the low efficiency and large loss of cascade pumping stations, aiming to maximize system efficiency, an optimized scheduling model of cascade pumping stations is established with consideration of multiple constraints, and the optimal scheduling method based on the improved sparrow search algorithm (BSSA) is proposed. The BSSA is initialized by the Bernoulli chaotic map to solve the insufficient initial diversity of the sparrow search algorithm (SSA). The random boundary strategy is introduced to avoid local optimum when dealing with the scheduling problem of pumping stations. The performance and improvement strategy of BSSA are verified by eight benchmark functions. Results show that BSSA has better convergence accuracy and faster speed. BSSA is applied to a three-stage pumping station considering three flow conditions, and compared with the current scheme, particle swarm optimization and genetic algorithm optimization schemes, the operation efficiency of SSA can be increased by 0.72–0.96%, and operation cost can be reduced by ¥263,000/a–¥363,300/a. On this basis, the improvement of 0.04–0.30% and ¥14,800/a–¥109,900/a can be further achieved by the BSSA, which confirms the feasibility and effectiveness of BSSA to solve the pumping station optimal scheduling problem. The findings present useful reference for the optimized scheduling of pumping station system.
Carta de Descartes ao Padre Gibieuf
Authors: Teruel Coelho Rafael
Published: September 2023

Trata-se da tradução de uma carta enviada por Descartes ao Pe. Gibieuf datada de 19 de janeiro de 1642.
Montaigne no Sacrifício de Ifigênia
Authors: FRANCO DALTON
Published: September 2023

Os Ensaios de Michel de Montaigne requisitam justiça num contrato social. O seu trabalho não está no primeiro grupo das correntes contratuais, como deveria estar, nem é bem lembrado no bojo das teorias políticas modernas. Quanto mais o lemos, mais entendemos a preguiça com a sua obra. Na primeira seção discutimos um caminho contratual. Em segundo lugar, argumentamos a clareza de uma sociedade pré-estatal no seu trabalho. Na terceira parte do artigo, apontamos uma razão cética de Estado, baseada numa figura institucional imperfeita, nascida do imperfeito. O conjunto de contradições fratricidas de seu tempo fazem-no convocar uma grande discussão sobre a necessidade da moderação e de instituições.

Palvras-chave: Ensaios; Ceticismo; Descompostura; Contrato social
O PROJETO ARQUITETÔNICO E OS CUSTOS DAS ESTRUTURAS DE MADEIRA ENGENHEIRADA
Authors: Lotufo Oliveira Gabriela , Lopes de Oliveira Fabiana , Vilela Ramon
Published: September 2023

Tratando-se especificamente da construção de estruturas de madeira engenheirada, informações acerca de seus custos ainda são muito restritas, assim como a divulgação de pesquisas que relacionam os fatores de influência na composição final desse valor. Consequentemente, profissionais que trabalham no setor, deparam-se recorrentemente com a indagação: “qual o custo da estrutura por metro quadrado?”. A métrica de precificação por área construída de edificação por certo é a mais empregada para determinação de estimativas de custos, ainda que não pareça a mais adequada para valorar a tecnologia construtiva em estudo. Dessa forma, pretende-se aqui entender qual a real influência do projeto arquitetônico nos custos de uma estrutura de madeira engenheirada composta majoritariamente por painéis de CLT. Para isso, foram analisados orçamentos realizados por um fabricante nacional da tecnologia, visando compreender quais os principais fatores que interferem na composição de custos dessas estruturas e quais são aqueles que possuem relação direta com o projeto arquitetônico. Ao final, mesmo considerando o tamanho reduzido da amostragem analisada, foi possível demonstrar a relação direta existente entre a concepção do projeto e a otimização da estrutura de madeira engenheirada.
Import-Substitution as a Factor of Developing Sustainable Economy
Authors: Arushanova N. A.
Published: September 2023

Volatile economic and political situation in the world makes us search for new ways and methods of sustainable development of economy. The article deals with one of these methods and an acute challenge, i. e. importsubstitution. The author analyzes the need to develop import-substitution as a way to overcome stagnation in order to retain and grow our economy potential and to provide an opportunity for Russian enterprise products to enter the international market. Apart from that, import-substitution is a key factor of raising security of our economy and its sustainable development in volatile conditions of foreign-economic environment. The article describes measures of support in respect of agriculture adopted by the Government of the Russian Federation after introduction of first sanctions in March 2014. Positive and adverse aspects of import-substitution policy in the sphere of foods were discussed and statistics on it was provided. On the basis of the research the author shows results of the importsubstitution process.
The Role of University Integration in Overcoming the Gap between Education Results and Real Needs of Labour Market
Authors: Shaheen M.
Published: September 2023

The article discusses the topic of overcoming the gap between results of professional education and actual needs of labour market in the current situation and the role of universities in the problem solution. Due to the fact that professional education provides students with a lot of important and fundamental knowledge in a certain sphere, but labour market needs change faster than the basic curriculum a gap turns up between education programs and requirements advanced to workers. As a result we can observe a situation when a qualified specialist possesses plenty of theoretical knowledge, but few practical skills necessary for work. It is an important and acute challenge for the education sphere, labour market and in the long run for society in general. The article studies key notions connected with interaction between labour market and education, proposes possible ways to cut the gap between education results and real needs of labour market and highlights potential barriers that can hinder this process. The author provides concrete examples of successful solution of the problem within the frames of implementing various partner programs of business and education both in Russia and abroad.
conceito de dislexia em diálogo com gestores, professores, familiares e estudantes da educação básica
Authors: Pottmeier Sandra , Santana Ana Paula
Published: September 2023

Este artigo, de abordagem qualitativa, é resultado de uma pesquisa que busca compreender de que forma gestores, professores de Língua Portuguesa, família e os próprios escolares compreendem o conceito de Dislexia. O aporte teórico-metodológico inscreve-se na perspectiva enunciativa-discursiva, a qual fundamenta as análises dos registros coletados, envolvendo 15 sujeitos (estudantes, familiares, professoras de Língua Portuguesa e gestoras de duas escolas da rede pública). Os resultados apontaram para sujeitos que desconhecem ou pouco sabem o que é a Dislexia, compreendendo-a a partir de uma perspectiva biológica/organicista e distanciando-se de uma visão sociocultural. Além disso, também desconhecem sobre as políticas e leis de inclusão. Considera-se, a partir desta pesquisa, que há necessidade de formação interdisciplinar que envolva tanto gestores, educadores e profissionais da saúde para que se possa lançar um olhar para práticas pedagógicas voltadas para processos de ensino e aprendizagem de forma integrada, considerando a singularidade constitutiva dos aprendizes.
linguagem musical e seus múltiplos sentidos
Authors: Reis Leandro Augusto dos
Published: September 2023

O presente ensaio teórico objetiva discutir as relações entre o conceito de Letramento e o processo de musicalização, como possibilidade para se pensar o Letramento Musical. Para tanto, parte-se da ideia da música como linguagem intrinsicamente relacionada à percepção, ou seja, uma linguagem dos sentidos. Embora a experiência perceptiva seja necessária no processo de construção dos aspectos musicais, ela não é suficiente para dar sentido ao real. Faz-se necessária, portanto, a atribuição de significado pelo sujeito. Esse pensamento encontra eco na Epistemologia Genética de Jean Piaget (1896-1980), em especial no modo como essa teoria concebe a construção do real. Os processos de fazer e compreender música vinculam-se ao modo de atribuir sentido às construções envolvidas na linguagem musical. Desse modo, as aprendizagens de música por meio do Letramento Musical devem considerar a totalidade da música em contexto de suas aprendizagens e não a fragmentação de seus conteúdos.
Faith and Good Deeds in the Context of Islamic Soteriology
Authors:   St. Petersburg State University, Mariia Sviatoslavovna Shavrina
Published: September 2023

The article deals with issues of Islamic soteriology and focuses on the problem of religious other. The author examines the debatable issues of the relationship between faith (īmān) and deed (ʿamal) in Islam, and the soteriological conception of Iranian thinker Murtaza Mutahhari focusing on non-Muslims and their good deeds. In the first part of the study, the author presents the classical approaches of different schools and the contemporary stance of Islamic thinkers in the context of the problem under study. In the second part, the main approaches of Murtaza Mutahhari to the problem of salvation of virtuous non-Muslims are identified. According to the author, these approaches remain relevant in the context of religious pluralism, the need for peaceful coexistence among different faiths, and the representation and justification of Islamic forms of soteriological exclusivism, inclusivism, and pluralis.
Key Tourism Development Factors in the UAE
Authors:   Dagestan State University, Djamilya Adamkadievna Gusenova
Published: September 2023

The article analyzes the practical steps of UAE state institutions to encourage the development of tourism in the country, while observing a compromise between the forced liberalization of certain spheres of social life under the pressure of external and internal circumstances, and the preservation of Islamic canons as a dominant in the ideological and practical field. It is noted that the development of the tourist sector in UAE economy became possible due to the achievement of a balance between global trends and preserving a conservative way of life in the society based on the principles of Islamic ethics. The latter reveals itself in the corporate culture – voluntary corporate social responsibility, and a strict migration policy, known as kafala, which is a component of the industrial relations between the employer (contractor) and the migrant worker. The reduction of potential socio-cultural tensions as a result of the influx of tourists from a foreign cultural environment is achieved by the state not only through the implementation of various state programmes aimed at maintaining Islamic canons in the socio-economic and spiritual spheres of the country, but also through the achievement of broad awareness of those entering the country of the presence of a wide range of prohibitions and restrictions. The author concludes that the Islamic factor combined with a nationally oriented domestic policy can lead to impressive results in travel activities, as has been achieved in the UAE.
The Problem of Differentiation Between Homage to and Worship of the Prophets and Awliya in Islamic Theological Discourse
Authors:   Dragomanov National Pedagogical University, Ludmila Borisovna Maevskaya , Khaisam Mukhammad Aga ,   Dragomanov National Pedagogical University
Published: September 2023

The problem of differentiation between homage to an worship of prophets and awliya is a centuries-long issue of Islamic theological science discussed by both theologians and secular researchers. Controversiasl attitudes thereto lead to an aggravation of relations in the religious environment and to a sharp deterioration of the socio-political situation in certain regions of the world. The latter can manifest itself in mutual accusations of disbelief by groups holding diametrally opposite views on this issue, which in some cases leads to armed conflicts. This issue has become one of the elements of the confrontation between Sufis and supporters of Wahhabism. The ways to resolve this conflict include strict adherence to the main Islamic sources of doctrine, namely the verses of the Holy Qur’an and authentic (mainly sahih, hasan) statements of Prophet Muhammad. The opinions of prominent theologians, representatives of madhhabs, are also to be considered if they do not contradict the Qur’an.
Analysis of Disinfection Technologies that can Increase the Efficiency of Indoor Logistics Processes, which has been Reduced due to the COVID Pandemic
Authors: Boldizsár Adrienn , Tóth Ákos , Török Erika , Pásztor Attila
Published: September 2023

As a result of the Coronavirus, both supply chain and internal logistics processes at factories have changed a lot. In many areas, the effectiveness of the logistics processes has declined because of the restrictions implemented against the virus. The study lists some adverse effects where logistics processes had to be modified due to the changing and protection measures against or negative effects of the virus. The authors also argue that these restrictions decreased the efficiency of logistics processes and workers' productivity. One option to increase the logistics sector's efficiency is to use air purification technologies, like the ones studied in this paper: UV-C, Bioxygen® or plasma-ion decontamination technologies. These disinfection processes can create a safe indoor environment. The authors analyse the examined technologies with SWOT analysis. The analysis results demonstrate which disinfection application is the most beneficial to help in improving indoor air quality for logistics processes.
Versenysportolók sporttevékenységgel kapcsolatos kiadásainak vizsgálata
Authors: Dorogi Kristóf Tibor
Published: September 2023

Az elmúlt évtizedekben a sport gazdasági szerepe világszerte növekedett, és ez alól Magyarország sem kivétel. A sport az egyik legfontosabb iparágak közé tartozik, amely jelentős gazdasági előnyöket kínál az országnak. Ennek megfelelően a sportgazdasági terület egyre nagyobb figyelmet kap, és egyre fontosabb szerepet játszik a nemzetközi és hazai gazdaságban egyaránt. A tanulmányban azt vizsgáltuk, hogy az embereknek mekkora kiadásai vannak a sportolással kapcsolatban. Kérdőíves felmérést végeztünk, demográfiai adatokon kívül, a sportolási szokásokra és sportolással kapcsolatos költéshajlandóságukra kérdeztünk rá. A válaszadók többsége versenysportoló, akik többnyire csapatsportágakban versenyeznek. Az eredmények szerint a megkérdezettek közül, aki csapatsportágat űz, annak semmivel sem kell több kiadásra számítania, havi szinten, mint azoknak az embereknek, akik egyéni sportágat űznek.
Determining the area of a technical system stability in fuzzy sets terms
Authors: Yastrebov M. Yu. , Komissarov P. V. , Kolesnichenko S. V.
Published: September 2023

Ensuring the stability of the technical systems functioning, including those in water transport, is an important area for the application of mathematical methods, including probabilistic and mathematical-statistical methods. The stochastic nature of disturbances affecting complex systems and worsening the level of stability of the latter should be reflected in the implemented human-machine control loops. One of the directions here is the accounting and use of (usually competing) expert assessments, on the one hand, and a reasonable definition of stability indicators, a choice from a variety of possibilities, on the other hand. From a general point of view of management theory, the method of using expert assessments developed in the paper can be considered as an integral part of the risk management problem that is being developed so far, mainly for economic systems and using only financial criteria. The concept of the minimum allowable efficiency of a technical system is introduced in the paper. On its basis, an approach in which the indicator of the stability of a technical system is linked to a system-wide criterion indicator of the quality of its functioning is implemented. The corresponding mathematical model as a problem of mathemati- cal programming is formulated. Approaches to its solution including for the nonconvex multiextremal case are discussed. A feature of the proposed approach to the definition of the integral indicator of the stability of the dynamics of a technical system is the use of expert assessments in determining the probable range of changes in the controlled variables of the optimization model, implemented as a mathematical programming problem, which logically leads to the use of fuzzy set theory. With the non-linearity of the objective functions and restrictions that arise in this case, the gradient method of searching for a conditional optimum is effective.
Patriation and Section 35: The Role of Allan Blakeney in Securing Indigenous Rights
Authors: Leeson Howard
Published: September 2023

This paper will attempt to do four things. First, it will review some of the background essential to understanding how Indigenous leaders were involved in the patriation process and why section 35 was adopted as part of the patriation package. Second, it will elaborate on the role of former Premier Allan Blakeney of Saskatchewan in securing the adoption of section 35. Third, it will examine some of the expectations for significant structural change to the Canadian political system that were contemplated by the non-Indigenous participants involved in the patriation negotiations and, most importantly, why those expectations were never met. Finally, the paper will attempt to answer the fundamental question: are Indigenous peoples and their rights protected by the adoption of a general section 35, or has the existence of such a general provision actually hindered progress toward a more complete reconciliation between Indigenous and non-Indigenous peoples in Canada?
Meanings of Life
Authors: Xiao Du , Hanru Sun
Published: September 2023

This study aims to explore the meaning of life for the interviewees from a more real-life perspective, thus trying to expand the answer to the question of the meaning of life. It goes beyond understanding the meaning of life from the perspective of vague and unclear philosophical concepts. This study analyzes the content of the face-to-face interviews by using the ikigai theory, which demonstrates the influence of cultural formulation, social negotiation, and institutional channeling on the formation of individuals’ meaning of life. Finally, an idea is provide that genetic factors may also influence the formation of meaning in one’s life.
Research on the Influence of Host Country’s Economic Policy Uncertainty on China’s OFDI
Authors: Wei Yixuan
Published: September 2023

The influence of host county economic policy uncertainty (EPU) on China’s outward foreign direct investment is examined in this article (OFDI). The impact of host country economic policy uncertainty on China’s OFDI is investigated using panel data from Chinese OFDI to 20 important investment countries from 2011 to 2020. A fixed effects model is used, with the host country’s economic policy uncertainty as the main explanatory variable and six significant variables chosen as control variables. According to the results of the empirical analysis, the host country’s economic policy uncertainty will inhibit investment from the home country to that country.
Menurunkan Perilaku Maladaptif Pada Gangguan Skizoafektif dengan Behavioral activation
Authors: Maulida Tiara , Prabowo Adhyatman
Published: September 2023

Schizoaffective disorder is a serious mental disorder that combines symptoms of schizophrenia with mood symptoms such as depression or mania. The main symptom of this disorder is affection problems, with possible motor movement and behavioral disorders. The study aims to develop effective treatment to reduce maladaptive behavior with behavioral activation. Assessment methods used through test and non-test techniques. Behavioral activation is a therapeutic approach that aims to overcome disorders by increasing positive activity and changing behavior patterns that hinder emotional well-being.  The results showed that behavioral activation can reduce maladaptive behavior of schizoaffective disorder. This meant that the duration of the subject's maladaptive behavior decreased as the intervention progresses until the end of the intervention.
Gangguan skizoafektif adalah gangguan mental serius yang menggabungkan gejala skizofrenia dengan gejala suasana hati seperti depresi atau mania. Gejala utama gangguan ini adalah masalah kasih sayang, dengan kemungkinan gangguan gerak motorik dan perilaku. Penelitian ini bertujuan untuk mengembangkan pengobatan yang efektif untuk mengurangi perilaku maladaptif dengan aktivasi perilaku. Metode penilaian yang digunakan melalui teknik tes dan non tes. Aktivasi perilaku merupakan pendekatan terapeutik yang bertujuan untuk mengatasi gangguan dengan meningkatkan aktivitas positif dan mengubah pola perilaku yang menghambat kesejahteraan emosional. Hasil penelitian menunjukkan bahwa aktivasi perilaku dapat menurunkan perilaku maladaptif gangguan skizoafektif. Artinya, durasi perilaku maladaptif subjek menurun seiring berjalannya intervensi hingga akhir intervensi.
La educación alimentaria fomenta el consumo de amaranto para mejorar el estado de nutrición infantil
Authors: Calderón Martínez María Elena , Taboada Gaytán Oswaldo Rey , López Pedro Antonio , Ortiz Torres Enrique , Argumedo Macías Adrián , Cervantes Rodríguez Margarita
Published: September 2023

El estado nutricional infantil es vulnerable ante crisis alimentarias, especialmente en zonas rurales; además, la falta de conocimientos en alimentación y patrones de consumo poco saludables aumentan el riesgo de mal­nutrición. La educación alimentaria focalizada y el aprovechamiento de cultivos tradicionales locales, como el amaranto, pueden favorecer la nutrición y seguridad alimentaria, enriqueciendo la cultura alimentaria local. Los objetivos del estudio fueron promover el consumo de amaranto a través de educación alimentaria para observar su efecto sobre indicadores nutricionales de niños y presentar la metodología implementada para fomentar el aprovechamiento de este recurso alimentario en la zona del estudio. Se planteó un diseño mixto, explicativo y longitudinal. Se realizó una evaluación basal a nueve niños entre tres y ocho años de Tochimilco, Puebla, quienes consumieron 20 g/día de amaranto reventado como complemento de platillos caseros durante cinco meses; se implementaron talleres alimentarios individuales y se monitoreó la antropometría y patrones de consumo. A través de la educación alimentaria focalizada en las familias, el amaranto se visibilizó y fue consumido en la dieta regular; aún en contingencia sanitaria permaneció disponible, accesible y estable en el paisaje alimentario familiar. Su ingesta y diversificación de platillos aumentaron en todos los casos, después de la educación alimentaria. Sobre los indicadores antropométricos, siete casos mejoraron y finalizaron con diagnóstico saludable, pero dos casos finalizaron con sobrepeso. Se concluyó que la educación alimentaria focalizada ayuda a incorporar al amaranto a la alimentación regular y posibilita el mejoramiento del estado nutricional de niños aún en crisis alimentarias.
THE AGREEMENT ON THE CONSTRUCTION OF MOSQUE INTERIORS IN THE PERSPECTIVE OF AL-IJĀRAH ALA AL- 'AMĀL CONTRACT IN ABDYA DISTRICT OF ACEH
Authors: Najimi Ahmad , Saifullah Saifullah , Mustaqim Riza Afrian
Published: September 2023

The practice of Borongan work agreement on the manufacture of mosque interiors between CV Serba Na Plafon and the mosque BKM is carried out in the form of an oral agreement and both parties have agreed to the contents of the agreement. However, after the work was completed and the work contract ended, there was damage to the interior of the mosque and the BKM mosque asked for responsibility for CV Serba Na Plafon. This study examines how the work agreement between the management of the BKM Mosque and the contractor in making the interior of the mosque and the review of the al-ijārah ala al-amāl contract on the agreement and implementation of mosque interior design work in Southwest Aceh Regency. This research is a descriptive qualitative research analysis with a normative sociological approach, where the data obtained comes from observations and interviews. Based on the results of the research, it is found that: First, the work agreement between the BKM and the contractor is carried out in the form of an oral agreement, in the agreement a three-month warranty is given to complete the work with the provision that if damage occurs, then all damage is not the responsibility of CV Seba Na Plafon. Second, the review of the al-ijārah ala al-amāl contract on the agreement and implementation of the mosque interior design work is not in accordance with the terms and conditions of the al-ijārah ala al-amāl contract. In its implementation, the BKM of the mosque asks for responsibility for damage to the interior of the mosque carried out by CV Serba Na Plafon, which should be according to the al- ijārah ala al-"amāl contract, the BKM of the mosque has no right to do so because the parties must adhere to the terms agreed upon at the beginning of the agreement. In Islamic law, the parties to the collaboration must comply with the agreements in the contract.
O melodrama enquanto estratégia comunicacional
Authors: Sousa Santos Thátilla , Lima Satler Lara
Published: September 2023

This article make an epistemological discussion about the topic of interest to actuate theories from the field of communication. In this way, a brief bibliographic research on melodrama is presented to then address the melodramatic characteristics that point to communicability and incommunicability, to highlight its connection with communication. As a result, melodrama is understood as part of a circular system of meaning construction that works through interpretation, interaction and reflection. Therefore, it’s suggested to consider the melodramatic narrative as a communicational strategy, instead of referring to the notion of melodrama as a closed genre, to perceive its language acting as a mediator of different audiovisual works and their receivers.
Síndrome de Imerslund-Gränsbeck: caso clínico.
Authors: Vargas Rodriguez Ledmar Jovanny , Rozo Ortiz Edwar Jassir , Acosta Pérez Camila Andrea , Barón Barón Javier Orlando , Siachoque Morantes Mariana
Published: September 2023

Introducción: el síndrome de Imerslund-Gräsbeck es un trastorno congénito infrecuente caracterizado por disminución de la vitamina B12, anemia megaloblástica y proteinuria.
Caso clínico: mujer de 58 años de edad con cuatro episodios de movimientos tónicos generalizados cuyos paraclínicos mostraban deficiencia de cianocobalamina, por lo que en el interrogatorio se reportaba la presencia de alteraciones en la marcha y síndrome constitucional que requería ampliar los estudios. Los exámenes de extensión confirmaron el síndrome de Imerslund-Gräsbeck tipo 1, de modo que se decidió continuar el manejo con cianocobalamina y valoración con nutrición, con lo que se obtuvo una adecuada evolución y se decidió dar egreso a la paciente.
Conclusión: esta patología tiene una baja prevalencia y afecta principalmente a la primera década de la vida, tiene predilección por el sexo femenino y se caracteriza por una disminución de la vitamina B12, que puede predisponer a otras alteraciones como ataxia y retraso en el crecimiento.
Hepatitis granulomatosa, descifrando un soslayado espectro: enfoue basado en un caso clínico
Authors: Rondón Carvajal Julián , Reyna Carrasco Óscar Andrés , Lara Viáfara Melissa Fernanda
Published: September 2023

La hepatitis granulomatosa es una entidad histopatológica bien definida que se caracteriza por la presencia de agregados de macrófagos modificados (de aspecto epitelioide) y otras células inflamatorias que se acumulan luego de la exposición persistente a antígenos, lo que induce una respuesta inmunitaria celular mediada por la liberación de varias citocinas (entre las que se destacan el interferón gamma [INF-γ], el factor de necrosis tumoral alfa [TNF-α] y la interleucina 12 [IL-12]) que estimulan la fusión de células mononucleares para culminar en la formación de células gigantes multinucleadas con un borde circundante de linfocitos y fibroblastos. Representa entre el 2 % y el 15 % de todos los estudios anatomopatológicos de hígado, en el curso por lo general de un patrón bioquímico de tipo infiltrativo o colestásico. Se propone un enfoque práctico a partir de un caso clínico retador de un paciente con fiebre de origen desconocido en una zona de incidencia intermedia para tuberculosis, como lo es Colombia.
Investigating the propagation of droughts under the influence of climate changes in Luanhe River Basin
Authors: li min , Feng Zilong , 张 铭锋
Published: September 2023

The analysis of the law of drought propagation under climate change is
of great significance for drought early warning and reducing social and
economic losses. In spite of large spatiotemporal variability in drought
propagation, the propagation probability and threshold from
meteorological to hydrological droughts were not examined at seasonal
and regional scales over the Luanhe River basin. To estimate the
propagation probability and threshold of the Luanhe River basin, the
meteorological and hydrological variables were obtained at a grid
resolution of 0.25◦ Lat × 0.25◦ Lon in this study. Based on the GAMLSS
framework, the stationary model and the non-stationary model were
constructed to capture the characteristics of seasonal droughts without
considering climate change and considering climate change. Then the
Copula model was constructed, and the drought propagation probability
and the threshold under stationary and non-stationary conditions were
calculated. The results show that, under the combined influence of AMO,
temperature, relative humidity and wind speed, the propagation
probabilities became larger and the propagation thresholds became
higher, especially in spring and winter in the upstream and midstream
regions. The increase in temperature and the decrease in relative
humidity may be the key factors contributing to the occurrence of
hydrological drought in the basin.
Dietary Advancement Therapy using milk and egg ladders among children with a history of anaphylaxis
Authors: Gallagher Aoife , Cronin Caoimhe , Heng Tessa Ah , McKiernan Anne , Tobin Ciara , Flores Laura , McGinley Anne Marie , Loughnane Conor , Velasco Roberto , Hourihane Jonathan O’B , Trujillo Juan
Published: September 2023

Background: Anaphylaxis is increasing in recent years, with
common triggers in infants being milk and eggs. Currently the mainstay
of treatment for milk and/or egg allergy is strict avoidance. Recently
new therapies have emerged including stepwise introduction of allergens
via a ladder approach. The suitability of infants for the ladders is
debated. This study aims to focus on the use of food ladders in children
with anaphylaxis to egg or milk. Methods: Retrospective review
of paediatric patients diagnosed with IgE-mediated milk and/or egg
allergy between 2011-2021. Inclusion and exclusion criteria applied.
Anaphylaxis defined as per the WAO amended criteria 2020. Data analysis
utilised SPSS Version 28. Results: 1552 patient charts
reviewed, 1094 excluded (n=458). 70 infants had anaphylaxis at diagnosis
(milk n=36, egg n=34). 77.8%-85.2% with anaphylaxis successfully
completed the ladder, 88.9-92.9% without anaphylaxis were successful.
Children who successfully completed the ladder did so at similar rates.
20.6-50% children presenting with anaphylaxis at diagnosis experienced
allergic symptoms during treatment, compared to 17.3-40.7% without
anaphylaxis. Reactions were mild, mostly cutaneous and not requiring
medical attention. Patients experiencing allergic symptoms while on the
ladder were less likely to successfully complete treatment.
Conclusion: Milk and egg ladders are a safe and effective way
of inducing tolerance in infants, including those with a history of
anaphylaxis at diagnosis. There are no obvious predictors for who will
experience allergic reactions while on the ladder, however these
children are less likely to complete the ladder so parents should be
educated in management of mild allergic reactions at home.
From academia to industry: how reinvention and understanding your motivations can help you find your path.
Authors: D'Cruz Louise
Published: September 2023

In July 1999, I took my final curtsey as an aspiring ballet dancer in
London. At the time, I was devastated, having been ‘assessed out’ by the
ballet school I’d attended the year after I finished high school in
Ireland. I wish I knew then what I know now: there are no endings in a
career, just different paths. It took a few more iterations for me to
learn that lesson. I hope my experience can provide some reassurance for
anyone out there grappling with their next career move.
Alcohol and Alcoholism associated Neurological disorders: Current updates in a global perspective and recent recommendations
Authors: Verma Henu Kumar , Sahu Prashanti , Lakkakula Bhaskar
Published: September 2023

Background: Alcohol Use Disorder (AUD) is a debilitating
condition characterized by an individual’s inability to control their
alcohol consumption despite adverse consequences. Understanding the
neurological aspects of AUD is crucial for effective intervention. This
review encompassed a comprehensive search of reputable databases,
revealing key insights. Objective: To gain a better
understanding of the neurological environment of alcoholism and to shed
light on the role of various neurotransmitters in the phenomenon of
alcoholism. Methods: A comprehensive search of online
databases, including PubMed, EMBASE, Web of Science, and Google Scholar,
was conducted to identify relevant articles. Results:
Neurotransmitters such as dopamine, GABA, serotonin, and glutamate play
pivotal roles in alcoholism. A disrupted balance of these
neurotransmitters contributes to the development and maintenance of AUD.
Genetic factors also heavily influence susceptibility to alcoholism,
with ADH1B and ALDH2 genes displaying significant impacts on risk.
Conclusion: This review will provide a detailed overview of the
neurobiology of alcohol addiction, followed by recent studies published
in the genetics of alcohol addiction, molecular mechanism and detailed
information on the various acute and chronic neurological manifestations
of alcoholism for the Future research.
Amazonian Tectonic Evolution of Ceraunius and Tractus Fossae, Mars, and Implications for Local Magmatic Sources
Authors: Shahrzad Stephanie , Bramham Emma K , Piazolo Sandra , Thomas Mark , Byrne Paul K.
Published: September 2023

The heavily faulted Martian terrains of Ceraunius Fossae and Tractus
Fossae, south of the Alba Mons volcano, have previously only been
considered as parts of larger tectonic studies of Alba Mons, and the
complexity of the faulting remains consequently unclear. As these
terrains are in midst of the large Tharsis’ volcanoes, the study of
their surface deformation has the potential to help unravel the
volcano-tectonic deformation history associated with the growth of
Tharsis, as well as decipher details of the responsible magma-tectonic
processes. In this study, we distinguish between faults and collapse
structures based on image and topographic evidence of pit-crater chains.
We mapped ~12,000 faults, which we grouped into 3
distinct fault groups based on orientation, morphology, and relative
ages. These show a temporal evolution in the mapped fault orientations
from NE to NS to NW, with associated perpendicular stress orientations.
Collapse features were also mapped and categorized into 4 different
groups: pit-crater chains, catenae, u-shaped troughs and chasma.
Examining the 4 collapse structures reveals that they are likely 4
different steps in the erosional evolution of pit-crater chains.
Together this revealed a structural history heavily influenced by both
local (radial to Alba Mons, Pavonis Mons and Ascraeus Mons) and regional
(Tharsis radial) lateral diking, and vertical diking from a proposed
Ceraunius Fossae centred magma source. This, along with an updated
crater size-frequency distribution analysis of the unit ages, reveals a
highly active tectonic and magmatic environment south of Alba Mons, in
the Late Amazonian.
Extreme dry advection dominates the record-breaking Yangtze River heatwave in midsummer of 2022
Authors: hu Shuai , Zhou Tianjun , Peng Dong dong , Jiang Wanyi , Lu Bo , Wu Bo , Chen Xiaolong , Zhang Lixia , Zhang Wenxia
Published: September 2023

The Yangtze River Valley (YRV) experienced an unprecedented heatwave in
midsummer of 2022, but the detailed physical processes involved in the
influence of anomalous large-scale atmospheric circulation on the
heatwave remain unknown. Here, we show that the positive meridional
gradient of anomalous atmospheric moisture at the middle-lower
troposphere and associated extreme dry air advection over the YRV are
key prerequisites for the formation of the 2022 YRV heatwave. The 2022
YRV heatwave is dominated by the interannual variability, which
contributes 72.7% to the total temperature anomalies. Diagnosis of the
surface heat budget equation indicates that the surface cloud radiative
forcing is the most important process in driving the 2022 YRV heatwave,
which is dominated by the positive surface short-wave cloud radiative
forcing associated with the suppressed precipitation and the middle-low
clouds. The suppressed precipitation is induced by the vertical
dynamical processes of anomalous moisture advection caused by the
anomalous descending flows over the YRV, which are driven by the
negative advection of anomalous latent heat energy by climatological
meridional wind (anomalous dry air advection) according to the
atmospheric moist static energy equation. Simulations from the
Lagrangian model FLEXPART further indicate that the moisture anomaly
over the north of YRV is mainly originated from the surface evaporation
in the YRV, implying that there is a positive land-air feedback during
the life cycle of the YRV heatwave. Our study adds a perspective to the
existing mechanism analyses of the 2022 YRV heatwave to serve accurate
climate prediction and adaptation planning.
Clonal Hematopoiesis of Indeterminate Potential (CHIP) and Incident Type 2 Diabetes Risk
Authors: Tobias Deirdre K. , Manning Alisa K. , Wessel Jennifer , Raghavan Sridharan , Westerman Kenneth E. , Bick Alexander G. , Dicorpo Daniel , Whitsel Eric A. , Collins Jason , Correa Adolfo , Cupples L. Adrienne , Dupuis Josée , Goodarzi Mark O. , Guo Xiuqing , Howard Barbara , Lange Leslie A. , Liu Simin , Raffield Laura M. , Reiner Alex P. , Rich Stephen S. , Taylor Kent D. , Tinker Lesley , Wilson James G. , Wu Peitao , Carson April P. , Vasan Ramachandran S. , Fornage Myriam , Psaty Bruce M. , Kooperberg Charles , Rotter Jerome I. , Meigs James , Manson JoAnn E. ,   TOPMed Diabetes Working Group and National Heart, Lung, and Blood Institute TOPMed Consortium
Published: September 2023

OBJECTIVE

Clonal hematopoiesis of indeterminate potential (CHIP) is an aging-related accumulation of somatic mutations in hematopoietic stem cells, leading to clonal expansion. CHIP presence has been implicated in atherosclerotic coronary heart disease (CHD) and all-cause mortality, but its association with incident type 2 diabetes (T2D) is unknown. We hypothesized that CHIP is associated with elevated risk of T2D.

RESEARCH DESIGN AND METHODS

CHIP was derived from whole-genome sequencing of blood DNA in the National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine (TOPMed) prospective cohorts. We performed analysis for 17,637 participants from six cohorts, without prior T2D, cardiovascular disease, or cancer. We evaluated baseline CHIP versus no CHIP prevalence with incident T2D, including associations with DNMT3A, TET2, ASXL1, JAK2, and TP53 variants. We estimated multivariable-adjusted hazard ratios (HRs) and 95% CIs with adjustment for age, sex, BMI, smoking, alcohol, education, self-reported race/ethnicity, and combined cohorts’ estimates via fixed-effects meta-analysis.

RESULTS

Mean (SD) age was 63.4 (11.5) years, 76% were female, and CHIP prevalence was 6.0% (n = 1,055) at baseline. T2D was diagnosed in n = 2,467 over mean follow-up of 9.8 years. Participants with CHIP had 23% (CI 1.04, 1.45) higher risk of T2D than those with no CHIP. Specifically, higher risk was for TET2 (HR 1.48; CI 1.05, 2.08) and ASXL1 (HR 1.76; CI 1.03, 2.99) mutations; DNMT3A was nonsignificant (HR 1.15; CI 0.93, 1.43). Statistical power was limited for JAK2 and TP53 analyses.

CONCLUSIONS

CHIP was associated with higher incidence of T2D. CHIP mutations located on genes implicated in CHD and mortality were also related to T2D, suggesting shared aging-related pathology.
Data-driven density prediction of AlSi10Mg parts produced by laser powder bed fusion using machine learning and finite element simulation
Authors: Bossen Bastian , Kuehne Maxim , Kristanovski Oleg , Emmelmann Claus
Published: September 2023

Powder bed fusion of metals using laser beam (PBF-LB/M) is a commonly used additive manufacturing process for the production of high-performance metal parts. AlSi10Mg is a widely used material in PBF-LB/M due to its excellent mechanical and thermal properties. However, the part quality of AlSi10Mg parts produced using PBF-LB/M can vary significantly depending on the process parameters. This study investigates the use of machine learning (ML) algorithms for the prediction of the resulting part density of AlSi10Mg parts produced using PBF-LB/M. An empirical data set of PBF-LB/M process parameters and resulting part densities is used to train ML models. Furthermore, a methodology is developed to allow density predictions based on simulated meltpool dimensions for different process parameters. This approach uses finite element simulations to calculate the meltpool dimensions, which are then used as input parameters for the ML models. The accuracy of this methodology is evaluated by comparing the predicted densities with experimental measurements. The results show that ML models can accurately predict the part density of AlSi10Mg parts produced using PBF-LB/M. Moreover, the methodology based on simulated meltpool dimensions can provide accurate predictions while significantly reducing the experimental effort needed in process development in PBF-LB/M. This study provides insights into the development of data-driven approaches for the optimization of PBF-LB/M process parameters and the prediction of part properties.
Entre o digital e o físico: integrando recursos com o GeoGebra para práticas criativas em espaços de aprendizagem
Authors: Lieban Diego
Published: September 2023

Neste artigo, são apresentados e discutidos exemplos de propostas que procuram privilegiar o aspecto interativo e criativo da matemática, seja com materiais físicos ou digitais. Através de abordagens que envolvem a Educação STEAM e a Cultura Maker, procura-se refletir sobre o papel docente e discente no processo de aprendizagem em espaços que não sejam restritos à sala de aula, com ênfase para a aprendizagem baseada em projetos. Em particular, é considerado o papel da formação tecnológica integrando o GeoGebra com tecnologias emergentes como impressão 3D e corte a laser, levando em conta a articulação com o conhecimento pedagógico e de conteúdo, à luz do modelo TPACK.
Pengaruh Dosis Pupuk dan Tinggi Permukaan Air pada Budidaya Padi Varietas M70D dengan Media Pasir
Authors: Ridwan Ridwan , Sholihah Annisa Mar'atus , Amien Elhamida Rezkia , Amin Muhammad
Published: September 2023

This study aims to obtain the most suitable combination of water table level and organic fertilizer dosage for the growth and production of M70D rice varieties in sand media. The tools used include glass pots with a thickness of 5 mm, digital scales, floats, pipes, sprayers, tape measure and ruler. The materials used were rice seeds of the M70D variety, husk charcoal, soil, river sand, water, granule organic ghally fertilizer, and liquid ghally organic fertilizer. The research method used was a factorial experiment in a completely randomized design with 2 factors, namely fertilizer dose (d) and water level (a) with each treatment repeated 3 times (U). The growth of rice plants (Oryza Sativa L.) variety M70D will be optimum if given a dose of 5 g of fertilizer in the vegetative phase. Whereas in the generative phase, it will be optimum with a 15 gr fertilizer dose. A water level of -1 cm below the surface had the best effect on plant height and number of leaves of Paddy (Oryza Sativa L.) variety M70D in the vegetative phase. Whereas in the generative phase, will be optimum with the water level of 0.5 cm. The application of a fertilizer dose of 15 g and a water level of 0.5 provides the most optimal effect for the growth and development of rice variety M70D. Keyword: Fertilizer, Glass, Paddy, Potted rice, Sand media.
Short-term effects of a digital patient journey solution on patient-reported outcomes and health care utilization in arthroplasty: a pragmatic randomized controlled trial
Authors: Jansson Miia , Liedes Hilkka , Vuorinen Anna-Leena , Harjumaa Marja , Similä Heidi , Koivisto Jonna , Puhto Ari-Pekka , Vesty Gillian , He Hong-Gu , Pikkarainen Minna
Published: September 2023

Mobile health solutions for patient support have been proposed as promising and safe alternatives to usual care in adults undergoing primary total hip and knee arthroplasty. Studies of such applications, however, have produced conflicting results and only moderate- to low-quality evidence.
This study aims to evaluate the short-term effects of a digital patient journey solution on patient-reported outcomes and health care utilization in patients undergoing total hip and knee arthroplasty using a pragmatic randomized controlled trial design. Randomly allocated patients in the control arm (n = 35, 64 ± 9 years) received usual care, while patients in the intervention arm (n = 34, 62 ± 11 years) received the digital patient journey solution in addition to usual care.
The primary outcome was health-related quality of life as measured by the EuroQol EQ-5D-5L scale. Secondary outcomes included functional recovery, pain, self-efficacy, patient experience, adherence to fast-track protocol, and health care utilization. Participants were followed from a preoperative surgical visit until a postoperative follow-up visit at 6–12 weeks.
The health-related quality of life, functional recovery, pain, patient experience, adherence to the fast-track protocol, and health care utilization did not differ between the arms. During the study, however, the self-efficacy to use digital health services (p=0.027) increased in the intervention arm.
The use of the digital patient journey solution was not superior to usual care in terms of patient-reported outcomes and health care utilization. However, the solution improved the self-efficacy of patients to use digital health services, which may lead to greater demand for similar digital offerings as patient become more familiar with mobile health solutions.