bluuebunny/crossref_metadata_2025 huggingface dataset:
Strengthening the Pharmacovigilance Programme in Nepal
Authors: KC Santosh , Tragulpiankit P , Gorsanam P , Edwards IR , Alam K
Published: June 2013

The aims of pharmacovigilance are early recognition of previously unknown adverse drug reactions (ADRs), recognition of changes in frequency of known ADRs, identification of risk factors and mechanism of ADRs, quantitative analysis of benefit/risk ratio and dissemination of safety information for rational drug prescribing and regulation. The pharmacovigilance programme in Nepal is a recent development. The Department of Drug Administration (DDA) took the initiative to set up a pharmacovigilance program in 2002; however, it was initiated systematically only after two years. DDA acts as the National Pharmacovigilance Centre (NPC). It collects ADR case reports from the Regional Pharmacovigilance Centre (RPC). Currently there are six RPCs operating in the country. The current reporting trends suggest high under-reporting of suspected ADRs. This paper is a review of those studies which are focused on pharmacovigilance and healthcare professionals’ perspectives on ADR reporting in Nepal. It also recommends the possible ways to improve the ADR reporting based on the context of Nepal.DOI: http://dx.doi.org/10.3126/nje.v3i1.8286 Nepal Journal of Epidemiology 2013;3 (1): 230-235
From Theory to Practice: Integrating Instructional Technology into Veterinary Medical Education
Authors: Wang Hong , Rush Bonnie R. , Wilkerson Melinda , Herman Cheryl , Miesner Matt , Renter David , Gehring Ronette
Published: July 2013

Technology has changed the landscape of teaching and learning. The integration of instructional technology into teaching for meaningful learning is an issue for all educators to consider. In this article, we introduce educational theories including constructivism, information-processing theory, and dual-coding theory, along with the seven principles of good practice in undergraduate education. We also discuss five practical instructional strategies and the relationship of these strategies to the educational theories. From theory to practice, the purpose of the article is to share our application of educational theory and practice to work toward more innovative teaching in veterinary medical education.
Glacier change of the Columbia Icefield, Canadian Rocky Mountains, 1919–2009
Authors: Tennant Christina , Menounos Brian
Published: July 2013

We determined length, area, elevation and volume change of the Columbia Icefield using Interprovincial Boundary Commission Survey maps from 1919, eight sets of aerial photographs from 1948 to 1993, and satellite data from 1999 to 2009. Over the period 1919–2009, glaciers on average retreated 1150 ± 34 m and shrank by 2.4 ± 0.2 km2. Total area loss was 59.6 ± 1.2 km2 (23 ± 5%), and mean elevation change was −49 ± 25 m w.e., resulting in a total volume loss of 14.3 ± 2.0 km3 w.e. Large outlet glaciers experienced the greatest absolute ice loss, while small, detached glaciers lost the most relative length and area. Thinning rates of debris-covered ice were 30–60% lower than those for clean ice. All glacier changes were significantly correlated with each other (p < 0.01), with r values ranging from 0.54 to 0.82. Temperature is correlated with length and area change over periods lagged 1–5 years (p < 0.05), and with elevation and volume change over periods lagged 9–18 years (p < 0.05). Precipitation is correlated with glacier change over periods lagged 1–10 years (p < 0.05).
Determination of effect of elliptic notches and grooves on stress concentration factors on notched bar in tension and grooved shaft under torsion
Authors: Ahsan Rumman Ul , Prachurja Protyasha , Ali Abu Raihan Mohammad , Mamun Mohammad Arif Hasan
Published: June 2013

Stress concentration of structural members can be reduced considerably by the judicious choice of elliptic shaped stress raisers like notch and groove. Substantial effort has been given by numerous researchers to accurately measure the effect of such stress raisers, particularly of semicircular shaped notch and groove. An exhaustive bibliographical study proved that there is scope to investigate further and establish an alternative design criteria; concerning the elliptic geometry. Computational method, primarily the finite element method has been used to analyze the models under loading. This paper suggests the use of a modified elliptic shape which gives less stress concentration when compared to semicircular notch and groove. The ratio of minor and major half axes of the ellipse should be between 0.3 and 0.4. The introduction of shoulder with elliptic notch and groove even reduces the stress concentration. The results obtained from FEM analysis propose optimal values of geometrical design parameters. The study represents not only a precise view of stress distribution, but also to develop charts that can be used by designer for practical purposes.DOI: http://dx.doi.org/10.3329/jname.v10i1.13675
Dynamic analysis of a tension leg platform under extreme waves
Authors: Chandrasekaran Srinivasan , Yuvraj Koshti
Published: June 2013

Recent observations of the sea state that result in the undesirable events confirm the presence of extreme waves like freak waves, which is capable of causing irreparable damages to offshore installations and (or) create inoperable conditions to the crew on board. Knowledge on the extreme wave environment and the related wave-structure interaction are required for safer design of deep-water offshore structures. In the current study, typical long crested extreme waves namely:  i) New Year wave at offshore Norway; and ii) Freak wave at North Sea are simulated using the combined wave model. Dynamic response of the Tension Leg Platforms (TLP) under these extreme waves is carried out for different wave approach angles. Based on the analytical studies cared out, it is seen that the TLPs are sensitive to the wave directionality when encountered by such extreme waves; ringing type response is developed in TLPs which could result in tether pull out.DOI: http://dx.doi.org/10.3329/jname.v10i1.14518
Les perspectives économiques en France pour le premier semestre 1956 d'après les chefs d'entreprises
Authors: Jankeliowitch R.
Published: July 2013

A la fin de 1955, les perspectives économiques apparaissent aux chefs d'entreprises à peu près les mêmes que six mois plus tôt. L'optimisme prévaut toujours dans les perspectives de production — sauf dans l'industrie textile — ainsi que dans celles des affaires commerciales. L'emploi de la main-d'œuvre paraît devoir s'accroître encore un peu. Les perspectives d'exportations sont sensiblement moins favorables qu'au printemps dernier. L'éventualité d'une hausse modérée du niveau général des prix est considérée maintenant comme probable par la majorité des chefs d'entreprises.
Les problèmes de l'économie laitière
Authors: Delage M. , Mills F.D.
Published: July 2013

Extraits d'exposés présentés à un cycle d'études sur les problèmes de l'économie laitière. - Réduction des coûts de production. Organisation des marchés (Royaume- Uni et Pays-Bas).
La famille d'Hypatie (Synésios, epp. 5 et 16 G.)
Authors: Roques Denis
Published: July 2013

Deux lettres de Synésios de Cyrène (dont l'une de 413) mentionnent, dans l'entourage immédiat d'Hypatie, deux personnages : Théoteknos et Athanasios, qualifiés respectivement de «père» et de «frère». Les érudits ont attribué à ces personnages des identités et des statuts différents, mais sans voir le lien familial étroit qui les unit à Hypatie. Théoteknos est en faitThéon d'Alexandrie, le père de la mathématicienne (le nom transmis par la tradition : Théon, n'est donc qu'un hypocoristique de Théoteknos). Quant à Athanasios, il est le frère d'Hypatie, et l'on doit le substituer, dans ce statut, à l'Épiphanios à qui Théon dédicaça plusieurs de ses ouvrages : celui-ci, qu'on a considéré comme le fils de l'astronome alexandrin (et donc comme le frère d'Hypatie) n'est qu'un disciple du maître. Ces considérations impliquent 1) que Théon d'Alexandrie vivait encore en 413 ; 2) que Synésios a connu directement ce personnage et a pu être en relation avec lui, de près ou de loin, durant presque vingt ans (de ca 395 à 413) ; 3) que ces liens expliquent, autant que l'amitié pour Hypatie, l'intérêt du Cyrénéen pour l'astronomie et, en particulier, pour l'œuvre de Théon, dont il paraît par ailleurs avoir commenté le Grand commentaire aux tables faciles de Ptolémée.
La Niobé d'Eschyle : quelques jalons
Authors: Moreau Alain
Published: July 2013

L'examen des fragments de la Niobé d'Eschyle (et en particulier du PSI 1208), des données du mythe et de certaines peintures de vases italiotes du ive siècle (très vraisemblablement en relation avec une représentation de la tragédie) permet d'obtenir un certain nombre de renseignements sur le contenu de la pièce : Eschyle n'avait traité qu'une partie du mythe, celle qui se situe aussitôt après le massacre des enfants. La scène se passe à Thèbes. Niobé demeure longtemps (durant les deux cinquièmes de la pièce environ), immobile et silencieuse, sur la tombe de ses enfants. Sa mère, la reine lydienne Euryanassa, tente en vain de l'arracher à sa prostation. C'est son père, Tantale, qui y parviendra à force de prières et peut-être d'offrandes. La pièce s'achève avec l'annonce du retour en Lydie et des allusions sont faites à la pétrification. Un thème parcourt la pièce, celui de l'hubris et du châtiment d'une race de théomachoi.
La composition des concepts dans le De Anima (III, 6) d'Aristote. Commentaires grecs et arabes
Authors: Fattal Michel
Published: July 2013

Cette étude se propose de comprendre l'expression σύνθεσις τῶν νοημάτων qui apparaît en De Anima III, 6, 430a 27-28. J'essayerai tout d'abord de montrer comment les noèmaia sont des concepts ou des universels abstraits d'une matière sensible ou intelligible, et comment certains commentateurs grecs et arabes envisagent le noêma à partir des notions d'« intelligible» (νοητόν en grec, ma'qūl en arabe) et de «signification» (σημαινόμενον en grec, ma'na en arabe). Il s'agira ensuite de voir en quoi la synthesis désigne une opération discursive de l'intellect (νοῦς) qui entretient des relations complexes avec la διάνοια, l'ὑπόληψις et la νόησις. Une confrontation du De Anima et du De Interpretation permet d'établir un parallèle entre l'activité du νοῦς et le caractère synthétique du verbe «être». C'est à travers les notions de rābiṭa et de tarkib que les traducteurs et commentateurs arabes développeront la pensée aristotélicienne de la synthesis.
Perceived crowding and encounter norms of KayaKers in Pacific rim national ParK reserve, canada
Authors: Randall Carleigh , Rollins Rick B.
Published: July 2013

This article investigates crowding and encounter norms of 375 kayakers visiting the Broken group Islands in Pacific Rim National Park Reserve, Canada. To measure encounter norms, kayakers evaluated photographs showing increasing densities of (a) kayaks on the water, (b) motorboats on
the water, and (c) tents at a campsite. Norm curve characteristics helped to define kayaker standards for quality marine tourism and recreation experiences, including minimum acceptable conditions at one time (4.8 kayaks, 2.2 motorboats, 4.7 tents). In addition, significant differences existed
between marine (39% felt crowded while on the water) and terrestrial (80% felt crowded while at campsites) perceptions of crowding. Implications for park management include a need to assess the appropriateness of both terrestrial and marine conditions when managing for kayak activity. This
may include a consideration of user quotas in marine and terrestrial settings, as well as expanding the number of available campsites.
Botany and a changing world: Introduction to the Special Issue on Global Biological Change
Authors: Weller Stephen G. , Suding Katharine , Sakai Ann K.
Published: July 2013

• The impacts of global change have heightened the need to understand how organisms respond to and influence these changes. Can we forecast how change at the global scale may lead to biological change? Can we identify systems, processes, and organisms that are most vulnerable to global changes? Can we use this understanding to enhance resilience to global changes? This special issue on global biological change emphasizes the integration of botanical information at different biological levels to gain perspective on the direct and indirect effects of global change. Contributions span a range of spatial scales and include both ecological and evolutionary timescales and highlight work across levels of organization, including cellular and physiological processes, individuals, populations, and ecosystems. Integrative botanical approaches to global change are critical for the ecological and evolutionary insights they provide and for the implications these studies have for species conservation and ecosystem management.
La Place de la Perle à Manama ou la territorialisation confessionnelle de l'affrontement politique au Bahreïn
Authors: Burdy Jean-Paul , Burdy-Dubesset François
Published: July 2013

En février-mars 2011, l’épisode le plus remarqué du « printemps de Manama » a été l’occupation de la place de la Perle, souvent comparée à celle de la place Tahrir, au Caire. Mais, le conflit politique au Bahreïn restant très largement fondé sur des tensions socio-confessionnelles, la Perle était moins une centralité urbaine que le point de convergence des quartiers chiites de la périphérie de Manama. Alors que le pouvoir et la base sociale de la dynastie tribale sunnite des Al Khalifa sont surtout installés dans un « bastion sunnite » au centre de l’île, hors de la ville capitale, l’opposition, majoritaire et chiite, est ancrée dans le vieux centre ville de Manama et dans les « villages chiites » du nord-ouest et du nord-est. La spatialisation de la séquence bahreïnie des « révolutions arabes » de 2011-2012 est donc restée fondamentalement marquée par le conflit confessionnel, dans des formes qui rappellent celles du conflit d’Irlande du Nord, à Belfast par exemple.
Le Mellah d'Essaouira, un quartier marginalisé
Authors: Messous Ouafa
Published: July 2013

Essaouira petite ville, fondée au XVIII e siècle, a été le théâtre de revendications sociales, à l’instar de nombreuses villes de la région. Cette ville vivant une grave récession économique, nous a servi de toile de fond pour tenter d’illustrer quelques aspects de « l’exception » du printemps arabe marocain. A travers l’analyse des trois marginalités vécues par l’ancien quartier juif de la ville, nous avons essayé de présenter quelques aspects des revendications sociales locales, leur évolution, ainsi que le rôle et le mode opératoire des différents acteurs impliqués ou concernés.
Les « absolus » en conflits : vers quel « universel » en partage ?
Authors: Bistolfi Robert
Published: July 2013

Dans un livre récent – « Saeculum – Culture, religion, idéologie » – le philosophe Etienne Balibar a abordé frontalement nombre de questions auxquelles se heurte la construction d’un « universel » réellement en partage. À « Confluences Méditerranée » l’on pense toujours qu’une « idée méditerranéenne » dégagée de ses anciennes connotations impériales aidera à la construction d’un avenir commun aux deux rives. Cette perspective exige toutefois que soient affrontés dans la clarté les éléments culturels conflictuels présents de part et d’autre : au Nord, un enracinement dans une tradition chrétienne que les vues universalistes issues des Lumières ont prolongé ; au Sud, un ancrage dans un islam porteur de convictions universalistes tout aussi fortes. Sur le dépassement du noyau dur des incompatibilités, sur les obstacles à surmonter, Etienne Balibar apporte des réflexions plus qu’éclairantes. Sans prétendre rendre compte de tous ses apports, le texte ci-après en analyse les principaux points.
Marqueurs identitaires religieux et laïcité
Authors: John Catherine
Published: July 2013

Les enfants et adolescents maghrébins en itep se regroupent, au fil des ans, en de petits groupes communautaires, aux revendications parfois agressives, se référant à l’islam. Que ce soit à l’occasion du Ramadan ou à d’autres, il arrive que surgisse chez les professionnels en institution la crainte d’une perte des valeurs laïques. Le risque est alors dans la crispation de passer à côté des questions ouvertes par des interrogations avant tout centrées sur la question de la construction identitaire, centrale à l’adolescence, qu’il nous appartient d’accompagner.
Les sciences hume/haine
Authors: Bosc Patrice
Published: July 2013

Ce texte, écrit à la suite d’une chronique de Brice Couturier sur France Culture, tente d’illustrer par quelques observations de la vie contemporaine et le relevé de la mesure qu’on en a généralement, l’enjeu pour les sciences humaines et le politique d’une rationalité qui n’expurgerait pas l’affect ou plus simplement le vécu. Il propose des images « découpées » dans nos villes, piqûres de la vie croisée, et d’autres représentations glanées dans les médias.
Giant Intraosseous Schwannoma of the Ileopubic Ramus
Authors: Benazzo Francesco , Marullo Matteo , Rossi Stefano Marco Paolo , Viola Erika
Published: July 2013

Schwannomas are the most common tumors of the peripheral nerves. Intraosseous schwannoma is a rare entity; approximately 200 cases are described in the world literature, with only 1 involving the ileopubic ramus. To the authors’ knowledge, this article is the first to describe a giant intraosseous schwannoma of the ileopubic ramus, its clinical presentation and radiographic aspect, its histological findings, its biological behavior, and the differential diagnosis. It is also the first to describe surgical treatment of this entity.

A 63-year-old woman presented with paroxysmal pain at the right groin. Radiographs showed a multilocular lytic lesion of the right ileopubic ramus, extending from the acetabulum to the pubic symphysis. Magnetic resonance imaging revealed extraosseous extension in the pelvis and in the anteromedial region of the right thigh. An incisional biopsy revealed fibroconnective tissue with sparse spindle cells in a myxoid stroma; diffuse expression of S100 protein was observed by immunohistochemistry. Intraosseous neurofibroma was the first histopathologic diagnosis. The 12×8×4-cm lesion was entirely removed via a Letournel ileoinguinal approach. Reconstruction of the ileopubic ramus was performed with an autologous bone graft taken from the omolateral iliac crest and fixed by a pelvic reconstruction plate. Histopathological examination revealed Antoni A and B patterns with Verocay bodies, no mitosis or cellular atypia, and diffuse expression of S100 protein by immunohistochemistry, all features indicative of a benign schwannoma. The patient returned to activities of daily living with no limitations. No recurrence had occurred 24 months postoperatively.
Modelling the impact of megacities on local, regional and global tropospheric ozone and the deposition of nitrogen species
Authors: Stock Z. S. , Russo M. R. , Butler T. M. , Archibald A. T. , Lawrence M. G. , Telford P. J. , Abraham N. L. , Pyle J. A.
Published: July 2013

Abstract. We examine the effects of ozone precursor emissions from megacities on present-day air quality using the global chemistry-climate model UM-UKCA. The sensitivity of megacity and regional ozone to local emissions, both from within the megacity and from surrounding regions, is important for determining air quality across many scales, which in turn is key for reducing human exposure to high levels of pollutants. We use two methods, perturbation and tagging, to quantify the impact of megacity emissions on global ozone. We also completely redistribute the anthropogenic emissions from megacities, to compare changes in local air quality going from centralised, densely populated megacities to decentralised, lower density urban areas. Focus is placed not only on how changes to megacity emissions affect regional and global NOx and O3, but also on changes to NOy deposition and to local chemical environments which are perturbed by the emission changes. The perturbation and tagging methods show broadly similar megacity impacts on total ozone, with the perturbation method underestimating the contribution partially because it perturbs the background chemical environment. The total redistribution of megacity emissions locally shifts the chemical environment towards more NOx-limited conditions in the megacities, which is more conducive to ozone production, and monthly mean surface ozone is found to increase up to 30% in megacities, depending on latitude and season. However, the displacement of emissions has little effect on the global annual ozone burden at the surface (0.12% change). Globally, megacity emissions are shown to increase total NOy deposition by ~3%. The changes in O3, NOx and NOy deposition described here are useful for quantifying megacity impacts and for understanding the sensitivity of megacity regions to local emissions. The small global effects of the 100% redistribution carried out in this study suggest that the distribution of emissions on the local scale is unlikely to have large implications for chemistry-climate processes on the global scale.
Simulating circuits with impasse points
Authors: Thiessen T. , Mathis W.
Published: July 2013

Abstract. In this paper circuits with impasse points, i.e. with jumps in their configuration space will be analyzed. These non-regularized circuits exhibit a fold in their configuration space, which can lead to difficulties during the simulation with standard circuit simulators like SPICE. The former developed geometric approach to simulate these circuits without regularization will be extended by a detailed discussion of which coordinate system has to be chosen. Furthermore, two new approaches for a numerically efficient calculation of the hit points will be shown.
Polarimetric radar cross section under SAR geometry
Authors: Phruksahiran N. , Chandra M.
Published: July 2013

Abstract. In this paper, the radar cross section of canonical scatter, with perfectly conducting surface, under the synthetic aperture radar geometry and polarized electromagnetic wave, has been considered and a new approach of polarized scattered electric field approximation for its evaluation has been developed.
Electromagnetic diffraction and scattering of a complex-source beam by a semi-infinite circular cone
Authors: Brüns H. , Klinkenbusch L.
Published: July 2013

Abstract. A complex-source beam (CSB) is used to investigate the electromagnetic scattering and diffraction by the tip of a perfectly conducting semi-infinite circular cone. The boundary value problem is defined by assigning a complex-valued source coordinate in the spherical-multipole expansion of the field due to a Hertzian dipole in the presence of the PEC circular cone. Since the incident CSB field can be interpreted as a localized plane wave illuminating the tip, the classical exact tip scattering problem can be analysed by an eigenfunction expansion without having the convergence problems in case of a full plane wave incident field. The numerical evaluation includes corresponding near- and far-fields.
Comparison of the Extended Kalman Filter and the Unscented Kalman Filter for Magnetocardiography activation time imaging
Authors: Ahrens H. , Argin F. , Klinkenbusch L.
Published: July 2013

Abstract. The non-invasive and radiation-free imaging of the electrical activity of the heart with Electrocardiography (ECG) or Magnetocardiography (MCG) can be helpful for physicians for instance in the localization of the origin of cardiac arrhythmia. In this paper we compare two Kalman Filter algorithms for the solution of a nonlinear state-space model and for the subsequent imaging of the activation/depolarization times of the heart muscle: the Extended Kalman Filter (EKF) and the Unscented Kalman Filter (UKF). The algorithms are compared for simulations of a (6×6) magnetometer array, a torso model with piecewise homogeneous conductivities, 946 current dipoles located in a small part of the heart (apex), and several noise levels. It is found that for all tested noise levels the convergence of the activation times is faster for the UKF.
Fusion of cooperative localization data with dynamic object information using data communication for preventative vehicle safety applications
Authors: Kloeden H. , Schwarz D. , Rasshofer R. H. , Biebl E. M.
Published: July 2013

Abstract. Cooperative sensors allow for reliable detection, classification and localization of objects in the vehicle's surroundings – even without a line-of-sight contact to the object. The sensor principle is based on a communication signal between the vehicle and a transponder attached to the object of interest – a pedestrian, for example. Thereby, localization information is gathered by measuring the round-trip time-of-flight (RTOF) and evaluating the angle-of-arrival (AOA) of the incident signal. After that, tracking algorithms are used to recover the kinematic state of the object providing a basis for situation assessment. This paper investigates possibilities and benefits of extending this principle by the communication of information from inertial sensors which are locally attached to the transponder. Furthermore, this paper presents a robust approach for fusing the localization data with dynamic object information using the Dempster-Shafer theory. The approach is evaluated by performing real-world experiments for the analysis of pedestrian accidents.
Recoil Induced Room Temperature Stable Frenkel Pairs in a-Hafnium Upon Thermal Neutron Capture
Authors: Butz Tilman , Das Satyendra K. , Dey Chandi C. , Ghoshal Shamik
Published: July 2013

Ultrapure hafnium metal (110 ppm zirconium) was neutron activated with a thermal neutron flux of 6:6 ·

1012 cm-2s-1 in order to obtain 181Hf for subsequent time differential perturbed angular correlation (TDPAC) experiments using the nuclear probe 181Hf(β-) 181Ta. Apart from the expected nuclear quadrupole interaction (NQI) signal for a hexagonal close-packed (hcp) metal, three further discrete NQIs were observed with a few percent fraction each. The TDPAC spectra were recorded for up to 11 half lives with extreme statistical accuracy. The fitted parameters vary slightly within the temperature range between 248 K and 373 K. The signals corresponding to the three additional sites completely disappear after ‘annealing’ at 453 K for one minute. Based on the symmetry of the additional NQIs and their temperature dependencies, they are tentatively attributed to Frenkel pairs produced by recoil due to the emission of a prompt 5:694 MeV -ray following thermal neutron capture and reported by the nuclear probe in three different positions. These Frenkel pairs are stable up to at least 373 K.
A study on achene macro- and micromorphological characters of Polish species of the Senecio jacobaea group
Authors: Bednorz Leszek , Podsiedlik Marek
Published: July 2013

A study on achene macro- and micromorphological characters of the following five Polish species of the Senecio jacobaea group was carried out by LM and SEM: S. aquaticus (var. aquaticus and var. barbareifolius), S. erucifolius (subsp. erucifolius and subsp. tenuifolius), S. jacobaea, S. paludosus, and S. subalpinus. The achenes differed in several characters, but the most distinctive differences concerned their indument, especially the length and morphology of hairs. The study clearly shows that two morphologically similar species, S. jacobaea and S. erucifolius, which are often confused can be easily distinguished based on the morphological characters of achenes. Additionally, we showed differences between the achenes of S. erucifolius subsp. erucifolius and subsp. tenuifolius, the two taxa which were not distinguished in floristic studies and herbarium collections from Poland. The key to determine Polish species of the Senecio jacobaea group, based on the morphological characters of achenes, is also given.
Microdeletion 5q14.3 and anomalies of brain development
Authors: Hotz Alrun , Hellenbroich Yorck , Sperner Jürgen , Linder‐Lucht Michaela , Tacke Uta , Walter Caren , Caliebe Almuth , Nagel Inga , Saunders Dawn E. , Wolff Gerhard , Martin Peter , Morris‐Rosendahl Deborah J.
Published: July 2013

5q14.3 deletions spanning and flanking MEF2C as well as intragenic MEF2C mutations have recently been described as a cause of severe intellectual disability, epilepsy, and muscular hypotonia, with variable brain and other anomalies. With an increasing number of patients described, the clinical presentation of the patients appears to be relatively uniform, however the structural brain phenotypes described are variable. We describe two unrelated patients with overlapping de novo interstitial deletions of 4.1 and 1.9 Mb, including MEF2C in 5q14.3, one of whom had a complex brain malformation which could be best described as microcephaly with simplified gyral pattern (MSG). Expression analysis in both patients confirmed haploinsufficiency for MEF2C, decreased MECP2 expression and increased C3ORF58 (DIA1) expression, which is a new finding. A detailed analysis of brain and white matter abnormalities reported in patients with 5q14.3 deletion syndrome to date revealed a greater number of reported abnormalities in patients with deletions not including MEF2C than those with deletions or mutations directly affecting MEF2C. Screening an additional 43 patients with malformations of cerebral cortical development (MCD) for mutations in MEF2C and/or deletions in 5q14.3q15, did not detect any additional mutations, allowing us to conclude that 5q14.3 deletion syndrome is a rare cause of microcephaly with simplified gyral pattern. © 2013 Wiley Periodicals, Inc.
Application of statistical techniques for elucidating flow cytometric data of batch and fed‐batch cultures
Authors: Shirsat Nishikant , Avesh Mohd , English Niall J. , Glennon Brian , Al‐Rubeai Mohamed
Published: July 2013

The objective of this work is to develop structured, segregated stochastic models for bioprocesses using time‐series flow cytometric (FC) data. To this end, mammalianCHOcells were grown in both batch and fed‐batch cultures, and their viable cell numbers (VCDs), monoclonal antibody (MAb), cell cycle phases, mitochondria membrane potential/mitochondria mass,Golgi apparatus, and endoplasmic reticulum (ER) were analyzed. For the fed‐batch mode, soy hydrolysate was introduced at 24‐H intervals. The cytometric data were analyzed for early indicators of growth and productivity by multiple linear regression analysis, which involved taking into account multicollinearity diagnostics,Durbin–Watson statistics, andHouston tests to determine and refine statistically significant correlations between categorical variables (FCparameters) and response variables (yield parameters). The results indicate that the percentage ofG1 cells andERwas significantly correlated withVCDandMAb in the case of batch culture, whereas for fed‐batch culture, the percentage ofG2 cells andERwas correlated significantly. There was a significant difference between cells in the batch and fed‐batch cultures in theirERcontent, suggesting that the increase in protein synthesis as reflected by theERcontent and consequent increase in growth rate andMAb productivity both can be monitored at the cellular level byFCanalysis ofERcontent.
Adjustment of Process Conditions in Seeded Batch Cooling Crystallization
Authors: Prlic Kardum J. , Hrkovac M. , Leskovac M.
Published: July 2013

The influence of seed addition temperature, seed surface area, and seeds of different origin on granulometric characteristics and polymorphism of glycine was examined. At sufficient surface seed area, a regular and narrow crystal size distribution (CSD) was obtained. Polymorphism was investigated by differential scanning calorimetry and X‐ray diffraction analysis. Differences in seed size and seed mass couple affected the granulometric properties but did not cause changes in polymorphic structure. Four experiments with different origin seeds were carried out under optimal process conditions determined by preliminary experiments. Various seed origins caused differences in supersaturation level and CSD but the structure of the obtained crystals remained the same as the loaded seed.
ChemInform Abstract: Structure, Atomistic Simulations, and Phase Transition of Stoichiometric Yeelimite.
Authors: Cuesta Ana , De la Torre Angeles G. , Losilla Enrique R. , Peterson Vanessa K. , Rejmak Pawel , Ayuela Andres , Frontera Carlos , Aranda Miguel A. G.
Published: July 2013

Ca4[Al6O12]SO4 (yeelimite) is prepared by solid state reaction of CaCO3, Al2O3, and CaSO4 (1300 °C, 4 h, slow cooling).
ChemInform Abstract: Chromium(V) Oxide Trichloride, and Some Pentachlorido‐oxido‐chromate(V) Salts: Structures and Spectroscopic Characterization.
Authors: Hector Andrew L. , Levason William , Light Mark E. , Reid Gillian , Sardar Kripasindhu , Zhang Wenjian
Published: July 2013

CrOCl3 crystallizes in the monoclinic space group P21/c with Z = 4 (single crystal XRD).
ChemInform Abstract: Dimensionally Reduced One‐Dimensional Chains of TiSe2.
Authors: Li Tianyang , Liu Yi‐Hsin , Porter Spencer , Goldberger Joshua E.
Published: July 2013

TiSe2(en) is prepared by dissolution of Se powder and NaBH4 in en followed by injection of TiCl4 (1.
ChemInform Abstract: Perovskite‐Structured BaScO2(OH) as a Novel Proton Conductor: Heavily Hydrated Phase Obtained via Low‐Temperature Synthesis.
Authors: Cervera Rinlee B. , Miyoshi Shogo , Oyama Yukiko , Elammari Youssef E. , Yagi Takehiko , Yamaguchi Shu
Published: July 2013

BaScO2(OH) is prepared by sol—gel reaction of Ba(O‐Bu)2 and Sc(O‐Pr)3 in 2‐methoxyethanol (reflux, 30 min) followed by hydrolyzation and crystallization in a steel vessel with a water vapor supply (150 °C, 2h).
ChemInform Abstract: Reversible Hydrogen Storage Properties of NaAlH4 Enhanced with TiN Catalyst.
Authors: Li Li , Wang Ying , Qiu Fangyuan , Wang Yijing , Xu Yanan , An Cuihua , Jiao Lifang , Yuan Huatang
Published: July 2013

A mixture of commercial NaAlH4 and 2 wt.% of nanocrystalline TiN is subjected to ball milling (stainless steel vessel, 450 rpm, 1 h, Ar atmosphere).
ChemInform Abstract: Enantioselective Mukaiyama—Michael Reaction of Silyl Enol Ethers to 2‐Enoylpyridine N‐Oxides Catalyzed by Copper‐Bis(oxazoline) Complex.
Authors: George Jimil , Reddy Basi V. Subba
Published: July 2013

A variety of silyl enol ethers such as (II) undergo Michael addition with 2‐enoylpyridine N‐oxides (I) to furnish the corresponding Michael adducts (III) in high yields and enantioselectivities.
ChemInform Abstract: Palladium‐Catalyzed Intermolecular Desulfinylative Cross‐Coupling of Heteroaromatic Sulfinates.
Authors: Sevigny Stephane , Forgione Pat
Published: July 2013

An efficient and environmentally benign palladium‐catalyzed protocol for the synthesis of aryl‐substituted heteroaromatics using a sulfinate as a nucleophilic coupling partner is developed.
ChemInform Abstract: Copper‐Catalyzed Decarboxylation of Aromatic Carboxylic Acids: En Route to Milder Reaction Conditions.
Authors: Cahiez Gerard , Moyeux Alban , Gager Olivier , Poizat Mael
Published: July 2013

The use of TMEDA is crucial to lower the reaction temperature of the decarboxylation reaction.
ChemInform Abstract: Modular Synthesis of Polyene Side Chain Analogues of the Potent Macrolide Antibiotic Etnangien by a Flexible Coupling Strategy Based on Hetero‐bis‐metalated Alkenes.
Authors: Altendorfer Mario , Raja Aruna , Sasse Florenz , Irschik Herbert , Menche Dirk
Published: July 2013

Hetero‐bis‐metalated alkenes (I) are used as building blocks for preparation of functionalized oligo‐enes by established coupling procedures.
ChemInform Abstract: Palladium‐Mediated [2 + 1] Cycloaddition of Norbornene Derivatives with Ynamides.
Authors: Clavier Herve , Lepronier Aymeric , Bengobesse‐Mintsa Nathalie , Gatineau David , Pellissier Helene , Giordano Laurent , Tenaglia Alphonse , Buono Gerard
Published: July 2013

The title reaction shows general applicability to various functionalized bicyclo[2.2.1]hept‐2‐enes, such as (I), (IV), (VII), (IX), and (XI) and ynamides.
ChemInform Abstract: Copper‐Catalyzed Hydrodefluorination of Fluoroarenes by Copper Hydride Intermediates.
Authors: Lv Hongbin , Cai Yuan‐Bo , Zhang Jun‐Long
Published: July 2013

A variety of fluorobenzenes and pentafluoropyridine are subjected to the methodology.
ChemInform Abstract: Nitrogen‐Doped sp2‐Hybridized Carbon as a Superior Catalyst for Selective Oxidation.
Authors: Gao Yongjun , Hu Gang , Zhong Jun , Shi Zujin , Zhu Yuanshuai , Su Dang Sheng , Wang Jianguo , Bao Xinhe , Ma Ding
Published: July 2013

The N‐doped graphite catalyst displays excellent activity for oxidation of arylalkanes in aqueous phase even at room temperature.
ChemInform Abstract: One‐Pot Oxidative Passerini Reaction of Alcohols Using a Magnetically Recyclable TEMPO under Metal‐ and Halogen‐Free Conditions.
Authors: Karimi Babak , Farhangi Elham
Published: July 2013

A novel domino oxidative Passerini three‐component reaction is developed with either primary or secondary alcohols (I) instead of their corresponding aldehydes and ketones by using a recyclable magnetic core‐shell nanoparticle supported TEMPO catalyst.
ChemInform Abstract: Stereospecific Allyl—Aryl Coupling Catalyzed by in situ Generated Palladium Nanoparticles in Water under Ambient Conditions.
Authors: Zhao Jingming , Ye Jiang , Zhang Yong Jian
Published: July 2013

The cross‐coupling of secondary allylic carbonates (I) and (IV) with arylboronic acids catalyzed by in situ generated Pd‐nanoparticles without any ligands and additional stabilizers is described.
ChemInform Abstract: Efficient Synthesis of 9,10‐Bis(phenylethynyl)anthracene Derivatives by Integration of Sonogashira Coupling and Double‐Elimination Reactions.
Authors: Toyota Shinji , Mamiya Daiki , Yoshida Rie , Tanaka Ryo , Iwanaga Tetsuo , Orita Akihiro , Otera Junzo
Published: July 2013

Starting from aldehyde (I), a combination of Sonogashira coupling and double elimination with benzyl phenyl sulfones is used to synthesize unsymmetrical title compounds as fluorescent building blocks in material chemistry.
ChemInform Abstract: Carbometalation—Carboxylation of 2,3‐Allenols with Carbon Dioxide: A Dramatic Effect of Halide Anion.
Authors: Li Suhua , Miao Bukeyan , Yuan Weiming , Ma Shengming
Published: July 2013

A convenient method for the synthesis of 2(5H)‐furanones is presented.
ChemInform Abstract: Rhodium‐Catalyzed Intermolecular Oxidative Cross‐Coupling of (Hetero)arenes with Chalcogenophenes.
Authors: Reddy Vutukuri Prakash , Qiu Renhua , Iwasaki Takanori , Kambe Nobuaki
Published: July 2013

The reaction of arenes and heteroarenes with thio‐ and selenophene derivatives proceeds via double C‐H bond cleavage by using Cu(O‐Ac)2 or Cu(O‐Ac)2/AgSbF6 as an oxidant.
ChemInform Abstract: Rhodium‐Catalyzed Direct Addition of Indoles to N‐Sulfonylaldimines.
Authors: Zhou Bing , Yang Yaxi , Lin Sui , Li Yuanchao
Published: July 2013

The Rh(III)‐catalyzed addition of indoles (I) to a variety of aromatic or alkyl‐N‐sulfonylimines (II) via C—H bond functionalization to afford 2‐indolylmethanamine derivatives (III) is reported.
ChemInform Abstract: Unprecedented One‐Pot, Domino Tertiary Alcohol Protection—Michael Type Addition of Halides to Morita—Baylis—Hillman Adduct of Isatin with RCOX/K2CO3: Diastereoselective Synthesis of Oxindole Appended β‐Halo Esters.
Authors: Solaiselvi Rajarethinam , Shanmugam Ponnusamy , Mandal Asit Baran
Published: July 2013

The tert‐hydroxyl protection in Morita—Baylis—Hillman (MBH) adducts of isatin using the system acyl halogenide/potassium carbonate is studied.
ChemInform Abstract: Organocatalytic Asymmetric Michael Addition of Aliphatic Aldehydes to Indolylnitroalkenes: Access to Contiguous Stereogenic Tryptamine Precursors.
Authors: Chen Jian , Geng Zhi‐Cong , Li Ning , Huang Xiao‐Fei , Pan Feng‐Feng , Wang Xing‐Wang
Published: July 2013

The Michael addition products can be further transformed into tryptamine derivatives, e.
ChemInform Abstract: Asymmetric Hydrogenation of Isoquinolinium Salts Catalyzed by Chiral Iridium Complexes: Direct Synthesis for Optically Active 1,2,3,4‐Tetrahydroisoquinolines.
Authors: Iimuro Atsuhiro , Yamaji Kenta , Kandula Sathaiah , Nagano Takuto , Kita Yusuke , Mashima Kazushi
Published: July 2013

In the presence of a chiral iridium catalyst, 1‐ and 3‐substituted as well as 1,3‐disubstituted isoquinolinium salts can be hydrogenated, giving the corresponding 1,2,3,4‐tetrahydroisoquinolines in high enantiomeric excess.
ChemInform Abstract: Scaffold Hopping via a Transannular Rearrangement—Encompassing Cascade.
Authors: Vrijdag Johannes L. , Van den Bogaert An M. , De Borggareve Wim M.
Published: July 2013

An efficient protocol for the preparation of oxazoloquinolinones using a flow method is described.
ChemInform Abstract: Exploring 6‐(Substituted sulfonyl)imidazopyridines as a Potential Scaffold for the Design of 5‐HT6 Ligands.
Authors: Heloire Valeria Moas , Furman Christophe , Melnyk Patricia , Carato Pascal
Published: July 2013

Novel imidazopyridine derivatives such as (X) are designed, synthesized, and evaluated for their ability to interact with 5‐HT6 receptors.
ChemInform Abstract: An Efficient Synthesis of Novel Sucrose‐Containing Dilactams
Authors: Potopnyk Mykhaylo A. , Jarosz Slawomir
Published: July 2013

such as (I) (6 examples)
ChemInform Abstract: Nanoparticles
Authors: Thomas P. John
Published: July 2013

Review: advances reported in 2011; 161 refs.
ChemInform Abstract: Functionalization Methods of Carbon Nanotubes and Its Applications
Authors: Chen Lifei , Xie Huaqing , Yu Wei
Published: July 2013

Review: 79 refs.
ChemInform Abstract: Recent Advances in Mechanochromic Luminescent Metal Complexes
Authors: Zhang Xiqi , Chi Zhenguo , Zhang Yi , Liu Siwei , Xu Jiarui
Published: July 2013

Review: 57 refs.
ChemInform Abstract: Off the Beaten Track: The Use of Secondary Amines in the Ugi Reaction
Authors: Tron Gian Cesare
Published: July 2013

Review: 37 refs.
ChemInform Abstract: Selective Alkane C—H Bond Substitutions: Strategies for the Preparation of Functionalized Diamondoids (Nanodiamonds)
Authors: Fokin Andrey A. , Schreiner Peter R.
Published: July 2013

Review: 172 refs.
ChemInform Abstract: Delocalized Lipophilic Cations as a Source of Naked Fluoride and Phase Transfer Catalysts
Authors: Kalinovich Nataliya , Kazakova Olesya , Roeschenthaler Gerd‐Volker
Published: July 2013

Review: 39 refs.
ChemInform Abstract: α‐Oxo Aldehyde or Glyoxylyl Group Chemistry in Peptide Bioconjugation
Authors: El‐Mahdi Ouafaa , Melnyk Oleg
Published: July 2013

Review: 272 refs.
ChemInform Abstract: Synthetic Survey and Activity of 2′‐Deoxy‐methanocarba Nucleosides
Authors: Guerra Krassimira P. , Afonso Carlos A. M.
Published: July 2013

Review: 102 refs.
ChemInform Abstract: Iron(0) Nanoparticle Catalysts in Organic Synthesis
Authors: Welther Alice , von Wangelin Axel Jacobi
Published: July 2013

Review: 92 refs.
ChemInform Abstract: Syntheses and Properties of Cyclosilazanes and Cyclocarbosilazanes
Authors: Kavala Miroslav , Hawkins Alison , Szolcsanyi Peter
Published: July 2013

Review: 80 refs.
ChemInform Abstract: Fluorescent Amino Acids: Modular Building Blocks for the Assembly of New Tools for Chemical Biology
Authors: Krueger Andrew T. , Imperiali Barbara
Published: July 2013

Review: 98 refs.
ChemInform Abstract: The Biosynthesis of Nitrogen‐, Sulfur‐, and High‐Carbon Chain‐Containing Sugars
Authors: Lin Chia‐I. , McCarty Reid M. , Liu Hung‐wen
Published: July 2013

Review: 219 refs.
ChemInform Abstract: New Materials for Biosensor Construction
Authors: Singh Man , Kale R. K. , Singh Sunita
Published: July 2013

Review: 34 refs.
ChemInform Abstract: Determination of Diphenylamine in Contaminated Air of Agricultural Buildings Using Active Sampling on Solid Sorbents
Authors: Gagoulia Athanasia G. , Amvrazi Elpiniki G. , Tsiropoulos Nikolaos G.
Published: July 2013

Review: 35 refs.
ChemInform Abstract: High‐Resolution Solid‐State NMR Spectroscopy of Steroids and Their Derivatives
Authors: Sievanen Elina , Kolehmainen Erkki
Published: July 2013

Review: 84 refs.
Enhanced H2 Separation through Mixed Proton–Electron Conducting Membranes Based on La5.5W0.8M0.2O11.25−δ
Authors: Escolastico Sonia , Seeger Janka , Roitsch Stefan , Ivanova Mariya , Meulenberg Wilhelm A. , Serra José. M.
Published: July 2013

La5.5WO11.25−δ is a proton‐conducting oxide that shows high protonic conductivity, sufficient electronic conductivity, and stability in moist CO2 environments. However, the H2 flows achieved to date when using La5.5WO11.25−δ membranes are still below the threshold for practical application in industrial processes. With the aim of improving the H2 flow obtained with this material, La5.5WO11.25−δ was doped in the W position by using Re and Mo; the chosen stoichiometry was La5.5W0.8M0.2O11.25−δ. This work presents the electrochemical characterization of these two compounds under reducing conditions, the H2 separation properties, as well as the influence of the H2 concentration in the feed stream, degree of humidification, and operating temperature. Doping with both Re and Mo enabled the magnitude of H2 permeation to be enhanced, reaching unrivaled values of up to 0.095 mL min−1 cm−2 at 700 °C for a La5.5W0.8Re0.2O11.25−δ membrane (760 μm thick). The spent membranes were investigated by using XRD, SEM, and TEM on focused‐ion beam lamellas. Furthermore, the stability in CO2‐rich and H2S‐containing atmospheres was evaluated, and the compounds were shown to be stable in the atmospheres studied.
Single transistor high linearity and wide dynamic range active inductor
Authors: Leuzzi G. , Stornelli V. , Pantoli L. , Del Re S.
Published: July 2013

In this paper, an active inductor (AI) with high linearity and high dynamic range, including a minimum number of components, is presented. The AI is composed by a single transistor, and by a passive compensation network; the latter allows the control of the values of both the inductance and the series resistance.

In order to show the feasibility of the proposed AI for filter applications, a prototype board on a TLX8 substrate with a first‐order active band‐pass filter has been fabricated and tested. The filter has a center frequency of 2470 MHz (useful for Bluetooth applications) and a measured noise figure (NF) of 9 dB with a −5 dBm P1dB compression point, and a 75 dB dynamic range. Copyright © 2013 John Wiley & Sons, Ltd.
An authenticated group key distribution mechanism using theory of numbers
Authors: Liu Yanjun , Harn Lein , Chang Chin‐Chen
Published: July 2013

A group key distribution protocol can enable members of a group to share a secret group key and use it for secret communications. In 2010, Harn and Lin proposed an authenticated group key distribution protocol using polynomial‐based secret sharing scheme. Recently, Guo and Chang proposed a similar protocol based on the generalized Chinese remainder theorem. In this paper, we point out that there are some security problems of Guo and Chang's protocol and propose a simpler authenticated group key distribution protocol based on the Chinese remainder theorem. The confidentiality of our proposed protocol is unconditionally secure. Copyright © 2013 John Wiley & Sons, Ltd.