bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure Legends from Targeting the miR-221–222/PUMA/BAK/BAX Pathway Abrogates Dexamethasone Resistance in Multiple Myeloma
Authors: Zhao Jian-Jun , Chu Zhang-Bo , Hu Yu , Lin Jianhong , Wang Zhongqiu , Jiang Meng , Chen Ming , Wang Xujun , Kang Yue , Zhou Yangsheng , Chonghaile Triona Ni , Johncilla Melanie E. , Tai Yu-Tzu , Cheng Jin Q. , Letai Antony , Munshi Nikhil C. , Anderson Kenneth C. , Carrasco Ruben D.
Published: April 2023

Supplementary Figure Legends. Legend for Supplementary Figures S1-S4.
Supplementary Figure Legends from Intracellular Osteopontin Inhibits Toll-like Receptor Signaling and Impedes Liver Carcinogenesis
Authors: Fan Xiaoyu , He Chunyan , Jing Wei , Zhou Xuyu , Chen Rui , Cao Lei , Zhu Minhui , Jia Rongjie , Wang Hao , Guo Yajun , Zhao Jian
Published: April 2023

Supplementary Figure Legends. Legends for Supplementary Figures S1-S3.
Supplemental Video 3 from A Noninvasive Procedure for Early-Stage Discrimination of Malignant and Precancerous Vocal Fold Lesions Based on Laryngeal Dynamics Analysis
Authors: Unger Jakob , Lohscheller Jörg , Reiter Maximilian , Eder Katharina , Betz Christian S. , Schuster Maria
Published: April 2023

Supplemental Video 3: Endoscopic high-speed videos - T1a carcinoma. The video shows a short sequence of the laryngeal high-speed video from each subject of the cancer group. The segmentation of the vocal folds is also shown (red: right vocal fold, blue: left vocal fold)
Supplemental PVG Figure 2 from A Noninvasive Procedure for Early-Stage Discrimination of Malignant and Precancerous Vocal Fold Lesions Based on Laryngeal Dynamics Analysis
Authors: Unger Jakob , Lohscheller Jörg , Reiter Maximilian , Eder Katharina , Betz Christian S. , Schuster Maria
Published: April 2023

Supplemental PVG Figure 2. The phonovibrogram (PVG) from each subject of the precancerous lesion group is shown. The PVG is explained more detailed within the manuscript.
Supplementary Figure S7 from Vacuolar-ATPase Inhibition Blocks Iron Metabolism to Mediate Therapeutic Effects in Breast Cancer
Authors: Schneider Lina S. , von Schwarzenberg Karin , Lehr Thorsten , Ulrich Melanie , Kubisch-Dohmen Rebekka , Liebl Johanna , Trauner Dirk , Menche Dirk , Vollmar Angelika M.
Published: April 2023

Supplementary Figure S7. Archazolid induces DSB in 4T1 cells, which is compensated by iron.
Supplementary Figure S5 from Vacuolar-ATPase Inhibition Blocks Iron Metabolism to Mediate Therapeutic Effects in Breast Cancer
Authors: Schneider Lina S. , von Schwarzenberg Karin , Lehr Thorsten , Ulrich Melanie , Kubisch-Dohmen Rebekka , Liebl Johanna , Trauner Dirk , Menche Dirk , Vollmar Angelika M.
Published: April 2023

Supplementary Figure S5. Archazolid induces ferritin, transferrin and RRM2 mRNA levels.
Supplementary Figure S4 from Vacuolar-ATPase Inhibition Blocks Iron Metabolism to Mediate Therapeutic Effects in Breast Cancer
Authors: Schneider Lina S. , von Schwarzenberg Karin , Lehr Thorsten , Ulrich Melanie , Kubisch-Dohmen Rebekka , Liebl Johanna , Trauner Dirk , Menche Dirk , Vollmar Angelika M.
Published: April 2023

Supplementary Figure S4. Archazolid induces 6PF2K3 and aldolase C mRNA levels.
Supplementary Figure S2 from Vacuolar-ATPase Inhibition Blocks Iron Metabolism to Mediate Therapeutic Effects in Breast Cancer
Authors: Schneider Lina S. , von Schwarzenberg Karin , Lehr Thorsten , Ulrich Melanie , Kubisch-Dohmen Rebekka , Liebl Johanna , Trauner Dirk , Menche Dirk , Vollmar Angelika M.
Published: April 2023

Supplementary Figure S2. mRNA levels of ATP6V0C after knockdown.
Supplemental Movie 2 from Antibody-Dependent Phagocytosis of Tumor Cells by Macrophages: A Potent Effector Mechanism of Monoclonal Antibody Therapy of Cancer
Authors: Gül Nuray , van Egmond Marjolein
Published: April 2023

Fluorescent images from live cell imaging experiment demonstrated uptake of blue labeled chronic lymphocytic leukemia (CLL) cells by red labeled human macrophages in the presence of the anti-CD20 mAb rituximab. Time is indicated in minutes. Scale bar = 20 ÃŽÂ¼m.
Supplemental Movie 1 from Antibody-Dependent Phagocytosis of Tumor Cells by Macrophages: A Potent Effector Mechanism of Monoclonal Antibody Therapy of Cancer
Authors: Gül Nuray , van Egmond Marjolein
Published: April 2023

Overlay of bright field and fluorescent images from live cell imaging experiment demonstrated uptake of blue labeled chronic lymphocytic leukemia (CLL) cells by red labeled human macrophages in the presence of the anti-CD20 mAb rituximab. Time is indicated in minutes. Scale bar = 20 ÃŽÂ¼m.
Supplementary Methods, Figure Legends, Tables 1 - 2 from TUBB3/βIII-Tubulin Acts through the PTEN/AKT Signaling Axis to Promote Tumorigenesis and Anoikis Resistance in Non–Small Cell Lung Cancer
Authors: McCarroll Joshua A. , Gan Pei Pei , Erlich Rafael B. , Liu Marjorie , Dwarte Tanya , Sagnella Sharon S. , Akerfeldt Mia C. , Yang Lu , Parker Amelia L. , Chang Melissa H. , Shum Michael S. , Byrne Frances L. , Kavallaris Maria
Published: April 2023

Supplementary Table 1: Proteins that were identified to be differentially expressed in the cytoplasmic fraction of H460 ÃŽÂ²III-tubulin shRNA expressing NSCLC cells. Supplementary Table 2: Proteins that were identified to be differentially expressed in the nuclear fraction of H460 ÃŽÂ²III-tubulin shRNA expressing NSCLC cells.
Supplementary Figure 6 from TUBB3/βIII-Tubulin Acts through the PTEN/AKT Signaling Axis to Promote Tumorigenesis and Anoikis Resistance in Non–Small Cell Lung Cancer
Authors: McCarroll Joshua A. , Gan Pei Pei , Erlich Rafael B. , Liu Marjorie , Dwarte Tanya , Sagnella Sharon S. , Akerfeldt Mia C. , Yang Lu , Parker Amelia L. , Chang Melissa H. , Shum Michael S. , Byrne Frances L. , Kavallaris Maria
Published: April 2023

Suppression of ÃŽÂ²III-tubulin increases cell adhesion and decreases cell migration in NSCLC cells.
Supplementary Figure S3 from Cell–Cell Adhesion and Cytoskeleton Tension Oppose Each Other in Regulating Tumor Cell Aggregation
Authors: Saias Laure , Gomes Aurélie , Cazales Martine , Ducommun Bernard , Lobjois Valérie
Published: April 2023

Supplementary Figure S3. Inhibition of myosin IIa activity increases the kinetics of cell aggregation. Down-regulation of myosin IIa by transfection of MYH9 siRNA increased the kinetics of cell aggregation in HCT116 cells (see Fig. 5). A, western blotting (left) and immunofluorescent staining with anti-myosin IIA antibodies (right) demonstrates that MYH9 siRNA transfection inhibits myosin IIA (Myo IIA) expression in HCT116 cells after 72 hours. B, the selective myosin II inhibitor blebbistatin had a similar effect on aggregation as had MYH9 siRNA, as shown in time-lapse images (left) and measurements of area variation (right).
Supplementary Figure 3 from TUBB3/βIII-Tubulin Acts through the PTEN/AKT Signaling Axis to Promote Tumorigenesis and Anoikis Resistance in Non–Small Cell Lung Cancer
Authors: McCarroll Joshua A. , Gan Pei Pei , Erlich Rafael B. , Liu Marjorie , Dwarte Tanya , Sagnella Sharon S. , Akerfeldt Mia C. , Yang Lu , Parker Amelia L. , Chang Melissa H. , Shum Michael S. , Byrne Frances L. , Kavallaris Maria
Published: April 2023

Two-Dimensional Difference Gel Electrophoresis (2D-DIGE) of cytoplasmic and nuclear extracts of H460 NSCLC cells expressing ÃŽÂ²III-tubulin or control shRNA.
Supplementary Table S4 from Metastatic Competence Can Emerge with Selection of Preexisting Oncogenic Alleles without a Need of New Mutations
Authors: Jacob Leni S. , Vanharanta Sakari , Obenauf Anna C. , Pirun Mono , Viale Agnes , Socci Nicholas D. , Massagué Joan
Published: April 2023

Supplementary Table S4. Variant allele frequencies are listed for each sequence variation detected.
Supplementary Materials and Methods from Metastatic Competence Can Emerge with Selection of Preexisting Oncogenic Alleles without a Need of New Mutations
Authors: Jacob Leni S. , Vanharanta Sakari , Obenauf Anna C. , Pirun Mono , Viale Agnes , Socci Nicholas D. , Massagué Joan
Published: April 2023

Supplementary Materials and Methods. This file contains Supplementary Methods, References, and Figure Legends.
Supplementary Table S4 from Discovery and Validation of Biomarkers That Distinguish Mucinous and Nonmucinous Pancreatic Cysts
Authors: Park Jisook , Yun Hwan Sic , Lee Kwang Hyuck , Lee Kyu Taek , Lee Jong Kyun , Lee Soo-Youn
Published: April 2023

Overall diagnostic performance of the protein markers identified for the differential diagnosis of pancreatic cysts.
Supplementary Figure S4 from Metastatic Competence Can Emerge with Selection of Preexisting Oncogenic Alleles without a Need of New Mutations
Authors: Jacob Leni S. , Vanharanta Sakari , Obenauf Anna C. , Pirun Mono , Viale Agnes , Socci Nicholas D. , Massagué Joan
Published: April 2023

Supplementary Figure S4. Cancer associated genes affected by copy number variations.
Supplementary Table S1 from Discovery and Validation of Biomarkers That Distinguish Mucinous and Nonmucinous Pancreatic Cysts
Authors: Park Jisook , Yun Hwan Sic , Lee Kwang Hyuck , Lee Kyu Taek , Lee Jong Kyun , Lee Soo-Youn
Published: April 2023

Total identified cyst proteins using shotgun proteomics.
Supplemental Methods from Syntheses and Discovery of a Novel Class of Cinnamic Hydroxamates as Histone Deacetylase Inhibitors by Multimodality Molecular Imaging in Living Subjects
Authors: Chan C.T. , Qi J. , Smith W. , Paranol R. , Mazitschek R. , West N. , Reeves R. , Chiosis G. , Schreiber S.L. , Bradner J.E. , Paulmurugan R. , Gambhir S.S.
Published: April 2023

Supplemental Methods. Description of additional methods and procedures used in the study.
Supplemental Figure S5 from Syntheses and Discovery of a Novel Class of Cinnamic Hydroxamates as Histone Deacetylase Inhibitors by Multimodality Molecular Imaging in Living Subjects
Authors: Chan C.T. , Qi J. , Smith W. , Paranol R. , Mazitschek R. , West N. , Reeves R. , Chiosis G. , Schreiber S.L. , Bradner J.E. , Paulmurugan R. , Gambhir S.S.
Published: April 2023

Supplemental Figure S5. Determination of the specificity of 1A12 in inhibition of HDACs.
Supplemental Tables S1-S5 from The Estrogen Receptor Cofactor SPEN Functions as a Tumor Suppressor and Candidate Biomarker of Drug Responsiveness in Hormone-Dependent Breast Cancers
Authors: Légaré Stéphanie , Cavallone Luca , Mamo Aline , Chabot Catherine , Sirois Isabelle , Magliocco Anthony , Klimowicz Alexander , Tonin Patricia N. , Buchanan Marguerite , Keilty Dana , Hassan Saima , Laperrière David , Mader Sylvie , Aleynikova Olga , Basik Mark
Published: April 2023

Clinical data (S1); Expression levels of SPEN and PGR as evaluated with DNA microarrays (S2); IC50 values of SPEN-overexpressing T47D clones, SPEN-silenced MCF-7 clones and their respective controls (S3); Loss of heterozysity assessment using polymorphic microsatellite repeat markers (S4); Primers sequence for the sequencing of SPEN (S5).
Supplementary Figures S1-S5 from ITPR1 Protects Renal Cancer Cells against Natural Killer Cells by Inducing Autophagy
Authors: Messai Yosra , Noman Muhammad Zaeem , Hasmim Meriem , Janji Bassam , Tittarelli Andrés , Boutet Marie , Baud Véronique , Viry Elodie , Billot Katy , Nanbakhsh Arash , Ben Safta Thouraya , Richon Catherine , Ferlicot Sophie , Donnadieu Emmanuel , Couve Sophie , Gardie Betty , Orlanducci Florence , Albiges Laurence , Thiery Jerome , Olive Daniel , Escudier Bernard , Chouaib Salem
Published: April 2023

Supplementary Figures S1-S5. Figure S1. Differential susceptibility of 786-0, PRC3, and WT7 cell lines to NK-mediated lysis. Figure S2. Role of ANGPTL4 and ADM in RCC cell susceptibility to NK-mediated lysis. Figure S3. VHL and NK ligand expression in RCC cells. Figure S4. Silencing of HIF-2α and NK ligand expression in 786-0 cells. Figure S5. VHL status, targeting of HIF-2α or silencing of ITPR1 does not regulate autophagy in 786-0 cells.
Supplemental Figures S1-S8 from The Estrogen Receptor Cofactor SPEN Functions as a Tumor Suppressor and Candidate Biomarker of Drug Responsiveness in Hormone-Dependent Breast Cancers
Authors: Légaré Stéphanie , Cavallone Luca , Mamo Aline , Chabot Catherine , Sirois Isabelle , Magliocco Anthony , Klimowicz Alexander , Tonin Patricia N. , Buchanan Marguerite , Keilty Dana , Hassan Saima , Laperrière David , Mader Sylvie , Aleynikova Olga , Basik Mark
Published: April 2023

SPEN is mutated in T47D cells (S1); SPEN is down-regulated and mutated in breast cancer (S2); SPEN regulates cell growth and survival (S3); SPEN knockdown in triple negative breast cancer cell lines limits proliferation (S4); SPEN regulates cell death and survival (S5); SPEN regulates transcriptional activity of the Estrogen Receptor (S6); SPEN regulates response of ERα-positive breast cancer cells to tamoxifen (S7); SPEN does not affect ERα-positive breast cancer cells response to fulvestrant (S8).
Supplementary Tables 3-6 from High-Frequency Targetable EGFR Mutations in Sinonasal Squamous Cell Carcinomas Arising from Inverted Sinonasal Papilloma
Authors: Udager Aaron M. , Rolland Delphine C.M. , McHugh Jonathan B. , Betz Bryan L. , Murga-Zamalloa Carlos , Carey Thomas E. , Marentette Lawrence J. , Hermsen Mario A. , DuRoss Kathleen E. , Lim Megan S. , Elenitoba-Johnson Kojo S.J. , Brown Noah A.
Published: April 2023

Univariate Cox regression analysis for ISP progression to SNSCC, Multivariate Cox regression analysis for ISP progression to SNSCC, Summary of EGFR mutation status and clinicopathologic features of a large ISP cohort.
Supplementary Figure 2 from Pharmacological Inhibition of β3 Integrin Reduces the Inflammatory Toxicities Caused by Oncolytic Adenovirus without Compromising Anticancer Activity
Authors: Browne Ashley , Tookman Laura A. , Ingemarsdotter Carin K. , Bouwman Russell D. , Pirlo Katrina , Wang Yaohe , McNeish Iain A. , Lockley Michelle
Published: April 2023

Female CD1nu/nu mice with intraperitoneal SKOV3ip1 tumours were injected IP with dl922-947 (10 particles) or vehicle. mRNA and protein were extracted from the same tumours and cytokines at 1, 6 and 24 hours were compared to cytokines at 0 hours (3-5 mice were analysed per time point).
Supplementary Fig 6 from Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance
Authors: Gurden Mark D. , Westwood Isaac M. , Faisal Amir , Naud Sébastien , Cheung Kwai-Ming J. , McAndrew Craig , Wood Amy , Schmitt Jessica , Boxall Kathy , Mak Grace , Workman Paul , Burke Rosemary , Hoelder Swen , Blagg Julian , Van Montfort Rob L.M. , Linardopoulos Spiros
Published: April 2023

ddPCR analysis of drug-resistance mutations shows they are pre-existing in cancer cell lines and quickly introduced into a population of HCT116 cells.
Supplementary Fig 4 from Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance
Authors: Gurden Mark D. , Westwood Isaac M. , Faisal Amir , Naud Sébastien , Cheung Kwai-Ming J. , McAndrew Craig , Wood Amy , Schmitt Jessica , Boxall Kathy , Mak Grace , Workman Paul , Burke Rosemary , Hoelder Swen , Blagg Julian , Van Montfort Rob L.M. , Linardopoulos Spiros
Published: April 2023

CCT251455-resistant HCT116 clones.
Supplementary Fig 3 from Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance
Authors: Gurden Mark D. , Westwood Isaac M. , Faisal Amir , Naud Sébastien , Cheung Kwai-Ming J. , McAndrew Craig , Wood Amy , Schmitt Jessica , Boxall Kathy , Mak Grace , Workman Paul , Burke Rosemary , Hoelder Swen , Blagg Julian , Van Montfort Rob L.M. , Linardopoulos Spiros
Published: April 2023

CCT251455 kills cancer cells by inhibiting the kinetochore recruitment of SAC protein.
Supplementary Methods and References from Tenascin-C Protects Cancer Stem–like Cells from Immune Surveillance by Arresting T-cell Activation
Authors: Jachetti Elena , Caputo Sara , Mazzoleni Stefania , Brambillasca Chiara Svetlana , Parigi Sara Martina , Grioni Matteo , Piras Ignazio Stefano , Restuccia Umberto , Calcinotto Arianna , Freschi Massimo , Bachi Angela , Galli Rossella , Bellone Matteo
Published: April 2023

Supplementary Methods and References. Description of additional methods and procedures used in the study. Also includes Supplementary References.
Supplementary Figures S1-S10 from Rapamycin Impairs Antitumor CD8+ T-cell Responses and Vaccine-Induced Tumor Eradication
Authors: Chaoul Nada , Fayolle Catherine , Desrues Belinda , Oberkampf Marine , Tang Alexandre , Ladant Daniel , Leclerc Claude
Published: April 2023

Supplementary Figure S1. T-cell gating strategy in the spleen, lymph nodes and tumors. Supplementary Figure S2. Rapamycin treatments inhibit the lymphocyte recruitment to the spleen and abrogate CyaA-E7's effect. Supplementary Figure S3. MDSC gating strategies in the spleens, lymph nodes and tumors. Supplementary Figure S4. Impact of high-dose rapamycin treatment on CD8+ T-cells in the lymphoid tissues and tumor. Supplementary Figure S5. Impact of high-dose rapamycin treatment on tumor-infiltrating CD4+ T-cells. Supplementary Figure S6. Impact of low-dose rapamycin treatment on lymphoid recruitment to spleen and lymph nodes. Supplementary Figure S7. Impact of the low-dose rapamycin treatment on tumor-infiltrating T-cells. Supplementary Figure S8. Impact of the low-dose rapamycin treatment on CD8+ T-cells in the spleen and LN. Supplementary Figure S9. Lack of inhibitory effect of an early treatment by rapamycin. Supplementary Figure S10. Rapamycin inhibits the OVA-specific CTL responses in a dose-dependent manner. Supplementary Figure Legends. Legends for Supplementary Figures S1-S10.
Supplementary Tables S1-S4 from Androgen-Induced TMPRSS2 Activates Matriptase and Promotes Extracellular Matrix Degradation, Prostate Cancer Cell Invasion, Tumor Growth, and Metastasis
Authors: Ko Chun-Jung , Huang Cheng-Chung , Lin Hsin-Ying , Juan Chun-Pai , Lan Shao-Wei , Shyu Hsin-Yi , Wu Shang-Ru , Hsiao Pei-Wen , Huang Hsiang-Po , Shun Chia-Tung , Lee Ming-Shyue
Published: April 2023

Supplementary Tables S1-S4. Oligonucleotide primers used in this study (S1); Antibodies used in this study (S2); List of proteins identified from the conditioned media by LC-MS/MS analysis (S3); List of protein identities in the 160-kDa band of matrigel after LC/MS/MS analysis (S4).
Supplementary Tables S1-S5 from NKX3.1 Suppresses TMPRSS2–ERG Gene Rearrangement and Mediates Repair of Androgen Receptor–Induced DNA Damage
Authors: Bowen Cai , Zheng Tian , Gelmann Edward P.
Published: April 2023

Supplementary Tables S1-S5. RT-PCR primers (S1); Real time PCR primers (S2); ChIP PCR primers (S3); 3C primers (S4); ANOVA p-Values for ChIP Assays (S5).
Supplementary Methods and Reference from Androgen-Induced TMPRSS2 Activates Matriptase and Promotes Extracellular Matrix Degradation, Prostate Cancer Cell Invasion, Tumor Growth, and Metastasis
Authors: Ko Chun-Jung , Huang Cheng-Chung , Lin Hsin-Ying , Juan Chun-Pai , Lan Shao-Wei , Shyu Hsin-Yi , Wu Shang-Ru , Hsiao Pei-Wen , Huang Hsiang-Po , Shun Chia-Tung , Lee Ming-Shyue
Published: April 2023

Supplementary Methods and Reference. Description of additional methods and procedures used in the study. Also includes Supplementary Reference.
Supplemental Figures S1-S5 from Pancreatic Cancer Cell Migration and Metastasis Is Regulated by Chemokine-Biased Agonism and Bioenergetic Signaling
Authors: Roy Ishan , McAllister Donna M. , Gorse Egal , Dixon Kate , Piper Clinton T. , Zimmerman Noah P. , Getschman Anthony E. , Tsai Susan , Engle Dannielle D. , Evans Douglas B. , Volkman Brian F. , Kalyanaraman Balaraman , Dwinell Michael B.
Published: April 2023

Representative time plot of oxygen consumption rate (OCR) and extracellular acidification rate (ECAR) measurements & migratory and AMPK phosphorylation response to CXCL12 of patient-derived pancreatic cancer cells ; Characterization of murine-derived pancreatic cancer cells ; CXCL12-induced AMPK activity is Gαi and CXCR4 dependent ; CXCL12-induced AMPK activity is calcium dependent ; Cytostatic CXCL12 stimulates MYPT1 phosphorylation at T853 .
Supplementary Tables S1-S2 from CHK1 Inhibition Synergizes with Gemcitabine Initially by Destabilizing the DNA Replication Apparatus
Authors: Koh Siang-Boon , Courtin Aurélie , Boyce Richard J. , Boyle Robert G. , Richards Frances M. , Jodrell Duncan I.
Published: April 2023

Supplementary Tables S1-S2. Kinase specificity of S1181 (S1); Percentages of S-phase cells (S2).
Supplementary Figure S1 from Foretinib Is Effective Therapy for Metastatic Sonic Hedgehog Medulloblastoma
Authors: Faria Claudia C. , Golbourn Brian J. , Dubuc Adrian M. , Remke Marc , Diaz Roberto J. , Agnihotri Sameer , Luck Amanda , Sabha Nesrin , Olsen Samantha , Wu Xiaochong , Garzia Livia , Ramaswamy Vijay , Mack Stephen C. , Wang Xin , Leadley Michael , Reynaud Denis , Ermini Leonardo , Post Martin , Northcott Paul A. , Pfister Stefan M. , Croul Sidney E. , Kool Marcel , Korshunov Andrey , Smith Christian A. , Taylor Michael D. , Rutka James T.
Published: April 2023

Supplementary Figure S1. Subgroup-specific copy number aberrations in primary medulloblastomas
Supplemental Methods from Effective Cancer Vaccine Platform Based on Attenuated Salmonella and a Type III Secretion System
Authors: Xu Xin , Hegazy Wael A.H. , Guo Linjie , Gao Xiuhua , Courtney Amy N. , Kurbanov Suhrab , Liu Daofeng , Tian Gengwen , Manuel Edwin R. , Diamond Don J. , Hensel Michael , Metelitsa Leonid S.
Published: April 2023

Supplemental Methods
supplementary figure 5 from Microenvironmental Remodeling as a Parameter and Prognostic Factor of Heterogeneous Leukemogenesis in Acute Myelogenous Leukemia
Authors: Kim Jin-A , Shim Jae-Seung , Lee Ga-Young , Yim Hyeon Woo , Kim Tae-Min , Kim Myungshin , Leem Sun-Hee , Lee Jong-Wook , Min Chang-Ki , Oh Il-Hoan
Published: April 2023

supplementary figure 5: surface phenotypic characterization of primitive subpopulation of MSCs (P-MSCs).
Supplementary Materials and methods from Full-Length Semaphorin-3C Is an Inhibitor of Tumor Lymphangiogenesis and Metastasis
Authors: Mumblat Yelena , Kessler Ofra , Ilan Neta , Neufeld Gera
Published: April 2023

Supplementary Materials and methods. Contains the description of materials and methods used in the experiments shown in the supplementary figures and additional details for some of the methods and reagents used in the main manuscript which could not be described in sufficient detail in the main manuscript due to constraints of length.
supplementary figure 2 from Microenvironmental Remodeling as a Parameter and Prognostic Factor of Heterogeneous Leukemogenesis in Acute Myelogenous Leukemia
Authors: Kim Jin-A , Shim Jae-Seung , Lee Ga-Young , Yim Hyeon Woo , Kim Tae-Min , Kim Myungshin , Leem Sun-Hee , Lee Jong-Wook , Min Chang-Ki , Oh Il-Hoan
Published: April 2023

supplementary figure 2: expression levels of cytokine-related genes in MSCs co-cultured with normal or AML CD34+ cells.
Supplemental Movie 4 from Full-Length Semaphorin-3C Is an Inhibitor of Tumor Lymphangiogenesis and Metastasis
Authors: Mumblat Yelena , Kessler Ofra , Ilan Neta , Neufeld Gera
Published: April 2023

Supplemental Movie 4. A time lapse movie showing the effect FR-Sema3C on the proliferation of lymphatic endothelial cells (LEC).
Supplemental Movie 3 from Full-Length Semaphorin-3C Is an Inhibitor of Tumor Lymphangiogenesis and Metastasis
Authors: Mumblat Yelena , Kessler Ofra , Ilan Neta , Neufeld Gera
Published: April 2023

Supplemental Movie 3. A time lapse movie of proliferating lymphatic endothelial cells (LEC).
supplemental figure legends from Microenvironmental Remodeling as a Parameter and Prognostic Factor of Heterogeneous Leukemogenesis in Acute Myelogenous Leukemia
Authors: Kim Jin-A , Shim Jae-Seung , Lee Ga-Young , Yim Hyeon Woo , Kim Tae-Min , Kim Myungshin , Leem Sun-Hee , Lee Jong-Wook , Min Chang-Ki , Oh Il-Hoan
Published: April 2023

supplemental figure legends
Supplementary Figure Legends from STAT3 Blockade Inhibits Radiation-Induced Malignant Progression in Glioma
Authors: Lau Jasmine , Ilkhanizadeh Shirin , Wang Susan , Miroshnikova Yekaterina A. , Salvatierra Nicolas A. , Wong Robyn A. , Schmidt Christin , Weaver Valerie M. , Weiss William A. , Persson Anders I.
Published: April 2023

Supplementary Figure Legends from STAT3 Blockade Inhibits Radiation-Induced Malignant Progression in Glioma
Supplementary Figure 1 from Breast Cancer Detection by B7-H3–Targeted Ultrasound Molecular Imaging
Authors: Bachawal Sunitha V. , Jensen Kristin C. , Wilson Katheryne E. , Tian Lu , Lutz Amelie M. , Willmann Jürgen K.
Published: April 2023

Supplementary Figure 1. Composite IHC scores for B7-H3 vascular staining in whole tissue breast cancer samples.
Supplementary Tables S1-S2 from miR-25 Modulates Invasiveness and Dissemination of Human Prostate Cancer Cells via Regulation of αv- and α6-Integrin Expression
Authors: Zoni E. , van der Horst G. , van de Merbel A.F. , Chen L. , Rane J.K. , Pelger R.C.M. , Collins A.T. , Visakorpi T. , Snaar-Jagalska B.E. , Maitland N.J. , van der Pluijm G.
Published: April 2023

Supplementary Tables S1-S2. Real time-qPCR primers (S1); Primers used for cloning and mutagenesis (S2).
Supplementary Video S2 from Real-time Imaging of the Resection Bed Using a Handheld Probe to Reduce Incidence of Microscopic Positive Margins in Cancer Surgery
Authors: Erickson-Bhatt Sarah J. , Nolan Ryan M. , Shemonski Nathan D. , Adie Steven G. , Putney Jeffrey , Darga Donald , McCormick Daniel T. , Cittadine Andrew J. , Zysk Adam M. , Marjanovic Marina , Chaney Eric J. , Monroy Guillermo L. , South Fredrick A. , Cradock Kimberly A. , Liu Z. George , Sundaram Magesh , Ray Partha S. , Boppart Stephen A.
Published: April 2023

Negative surgical margin. Video OCT cross-sectional images of a negative tumor margin from the in vivo resection bed of a 72 year-old female WLE patient with invasive ductal carcinoma as the surgeon sweeps the handheld probe along the margin.
Supplementary Figures 1 - 4, Table 1 from Anti-CD20 Therapy Acts via FcγRIIIA to Diminish Responsiveness of Human Natural Killer Cells
Authors: Capuano Cristina , Romanelli Maddalena , Pighi Chiara , Cimino Giuseppe , Rago Angela , Molfetta Rosa , Paolini Rossella , Santoni Angela , Galandrini Ricciarda
Published: April 2023

Supplementary Figure Legends - Supplementary Figure Legends 1- 4. Supplementary Figure 1 - Evaluation of CD16 internalization upon rituximab- or ofatumumab-opsonised target interaction. Supplementary Figure 2 - Analysis of cytotoxic activity and degranulation induced by individual activating receptors. Supplementary Figure 3 - Rituximab-induced hyporesponsiveness is independent from IL-2 treatment. Supplementary Figure 4 - Lytic granule exocytosis is impaired in both CD16+ and CD16 down-regulated rituximab experienced NK cells. Supplementary Table 1 - CLL patient characteristics.
Supplementary Figure 5 from Tumor-Induced Pressure in the Bone Microenvironment Causes Osteocytes to Promote the Growth of Prostate Cancer Bone Metastases
Authors: Sottnik Joseph L. , Dai Jinlu , Zhang Honglai , Campbell Brittany , Keller Evan T.
Published: April 2023

Supplementary Figure 5: MMPs promote PCa migration and invasion. A) CM was isolated from MLO-Y4 and PCa cell lines, normalized by total protein concentration, and compared by zymography for MMP expression. Densitometry of zymograph assays is also presented. B) Densitometry of zymograph in Figure 4A of MMP activity. C) mRNA from MLO-Y4 cells exposed to pressure for 24 hours was analyzed by real time PCR for MMP2 and MMP9 expression and normalized to GAPDH. D) MLO-Y4 CM (0 mmHg) was incubated with batimastat to inhibit OCy-derived MMP. CM with batimastat or DMSO control where utilized to determine alterations in PCa migration and invasion. E) PCa cells were incubated in the indicated CM and recombinant MMP2 added at the indicated concentrations. MMP2 concentrations from 40 mmHg CM were recapitulated in 0 mmHg CM through addition of recombinant (exogenous) MMP2. Invasion of PCa towards CM with additional MMP2 was measured. PCR, densitometry, and MMP2 addition experiments were analyzed using One-way ANOVA with Bonferroni post-test. Student's two-tailed t-test was used to analyze MMP inhibition experiments. All bars represent significant relationships of p>0.05.
Supplementary Figure 3 from Tumor-Induced Pressure in the Bone Microenvironment Causes Osteocytes to Promote the Growth of Prostate Cancer Bone Metastases
Authors: Sottnik Joseph L. , Dai Jinlu , Zhang Honglai , Campbell Brittany , Keller Evan T.
Published: April 2023

Supplementary Figure 3: Osteocyte conditioned media promotes viability of breast and lung cancer cell lines. OCy CM was incubated with breast (MDA-MB-231 and MCF7) and lung (A549 and H441) tumor cells for 24 hours before determination of viability using resazurin. Student's two-tailed unpaired t-test was used to assess statistical differences; p<0.05.
Supplementary Figure 1 from Tumor-Induced Pressure in the Bone Microenvironment Causes Osteocytes to Promote the Growth of Prostate Cancer Bone Metastases
Authors: Sottnik Joseph L. , Dai Jinlu , Zhang Honglai , Campbell Brittany , Keller Evan T.
Published: April 2023

Supplemental Figure 1: PC3 growth in bone does not increase ImP. PC3 tumor cells were injected into SCID mice 24 hours prior to implant with a wireless pressure monitoring device. A) A small increase in ImP during week 2 was observed, but was not statistically significant. B) Significant bone lysis due to tumor growth was observed. Tumor induced bone lysis may be a mechanism for relieving the pressure associated with more osteoblastic PCa tumors such as ACE1 and DU145.
Supplemental Figure Legends from Tumor-Induced Pressure in the Bone Microenvironment Causes Osteocytes to Promote the Growth of Prostate Cancer Bone Metastases
Authors: Sottnik Joseph L. , Dai Jinlu , Zhang Honglai , Campbell Brittany , Keller Evan T.
Published: April 2023

Supplemental Figure Legends. Figure legends accompanying all supplementary figures and table.
Supplementary Table S3 from Hepatocellular Shuttling and Recirculation of Sorafenib-Glucuronide Is Dependent on Abcc2, Abcc3, and Oatp1a/1b
Authors: Vasilyeva Aksana , Durmus Selvi , Li Lie , Wagenaar Els , Hu Shuiying , Gibson Alice A. , Panetta John C. , Mani Sridhar , Sparreboom Alex , Baker Sharyn D. , Schinkel Alfred H.
Published: April 2023

Sorafenib and SG pharmacokinetic parameters in FVB mice (2-hour study).
Supplementary Figure 5 from Tuning Sensitivity of CAR to EGFR Density Limits Recognition of Normal Tissue While Maintaining Potent Antitumor Activity
Authors: Caruso Hillary G. , Hurton Lenka V. , Najjar Amer , Rushworth David , Ang Sonny , Olivares Simon , Mi Tiejuan , Switzer Kirsten , Singh Harjeet , Huls Helen , Lee Dean A. , Heimberger Amy B. , Champlin Richard E. , Cooper Laurence J.N.
Published: April 2023

Engraftment of intracranial tumor and CAR+ T-cell phenotype prior to administration of T cells
Supplementary Figure 2 from Therapeutic Targeting of the Warburg Effect in Pancreatic Cancer Relies on an Absence of p53 Function
Authors: Rajeshkumar N.V. , Dutta Prasanta , Yabuuchi Shinichi , de Wilde Roeland F. , Martinez Gary V. , Le Anne , Kamphorst Jurre J. , Rabinowitz Joshua D. , Jain Sanjay K. , Hidalgo Manuel , Dang Chi V. , Gillies Robert J. , Maitra Anirban
Published: April 2023

Supplementary Figure 2. H&E and Masson's trichrome staining of PDXs.
Supplementary Figure 1 from Therapeutic Targeting of the Warburg Effect in Pancreatic Cancer Relies on an Absence of p53 Function
Authors: Rajeshkumar N.V. , Dutta Prasanta , Yabuuchi Shinichi , de Wilde Roeland F. , Martinez Gary V. , Le Anne , Kamphorst Jurre J. , Rabinowitz Joshua D. , Jain Sanjay K. , Hidalgo Manuel , Dang Chi V. , Gillies Robert J. , Maitra Anirban
Published: April 2023

Supplementary Figure 1. Baseline TIGAR mRNA expression in tumors.
Supplementary Tables S1-S6 from Leptin–STAT3–G9a Signaling Promotes Obesity-Mediated Breast Cancer Progression
Authors: Chang Chao-Ching , Wu Meng-Ju , Yang Jer-Yen , Camarillo Ignacio G. , Chang Chun-Ju
Published: April 2023

Supplementary Tables S1-S6. List of proteins with expression levels significantly changed in MCF7 cells under leptin treatment using antibody array (S1); G9a is a new STAT3-associated protein under leptin treatment (S2); STAT3-G9a regulates a cohort of genes involved in cell differentiation process (S3); Body composition analysis from DEXA scans (S4); Categorization of tumor number and tumor type in each group of animals (S5); Elevated LEP, p-STAT3, and OBR levels are correlated with reduced miR-200c expression in diet-induced obesity and breast cancer rats (S6).
Supplementary Figures S1-S6 from Differentiation and Loss of Malignant Character of Spontaneous Pulmonary Metastases in Patient-Derived Breast Cancer Models
Authors: Bockhorn Jessica , Prat Aleix , Chang Ya-Fang , Liu Xia , Huang Simo , Shang Meng , Nwachukwu Chika , Gomez-Vega Maria J. , Harrell J. Chuck , Olopade Olufunmilayo I. , Perou Charles M. , Liu Huiping
Published: April 2023

Supplementary Figures S1-S6. Supplemental Figure S1. The Differentiation scores (Dscore) of primary tumors and lung met-derived tumors. Supplemental Figure S2. miRNA expression in breast tumors. Supplemental Figure S3. Increased miR-138 expression in metastases versus paired primary tumors. Supplemental Figure S4. FISH analysis of miR-138 gene copy number Supplemental Figure S5. Ability of the miR-138 activity signature to predict breast cancer-specific survival. Supplemental Figure S6. Downstream targets of miR-138.
Suppl Table S4 from Differentiation and Loss of Malignant Character of Spontaneous Pulmonary Metastases in Patient-Derived Breast Cancer Models
Authors: Bockhorn Jessica , Prat Aleix , Chang Ya-Fang , Liu Xia , Huang Simo , Shang Meng , Nwachukwu Chika , Gomez-Vega Maria J. , Harrell J. Chuck , Olopade Olufunmilayo I. , Perou Charles M. , Liu Huiping
Published: April 2023

Suppl Table S4. Predicted transcription factor binding sites
Supplementary figure 1Figure S1 from Decoy Receptor DcR1 Is Induced in a p50/Bcl3–Dependent Manner and Attenuates the Efficacy of Temozolomide
Authors: Mansour Nassir M. , Bernal Giovanna M. , Wu Longtao , Crawley Clayton D. , Cahill Kirk E. , Voce David J. , Balyasnikova Irina V. , Zhang Wei , Spretz Ruben , Nunez Luis , Larsen Gustavo F. , Weichselbaum Ralph R. , Yamini Bakhtiar
Published: April 2023

Supplementary figure 1. A, Venn diagram showing overview of genes significantly (FDR < 0.05) altered in response to TMZ in U87 cells stably expressing control or p105 shRNA. DCR1 (TNFRSF10C) was identified as a gene specific to control cells. B, flow cytometric analysis of DcR1 surface expression in U87 cells following treatment with 100 μM TMZ for the indicated time. C, flow cytometric analysis of DcR1 expression in U87-sh-cntl and U87-sh-p105 cells following treatment with TMZ at the indicated concentration. D, immunoblot with anti-p53 and anti-p21 antibodies in U87 cells at indicated time following treatment with 100 μM TMZ.
Supplementary Methods, Figures 1 - 7 from Genetic Regulation of Fate Decisions in Therapeutic T Cells to Enhance Tumor Protection and Memory Formation
Authors: Veliça Pedro , Zech Mathias , Henson Sian , Holler Angelika , Manzo Teresa , Pike Rebecca , Santos e Sousa Pedro , Zhang Lei , Schiedlmeier Bernhard , Pule Martin , Stauss Hans , Chakraverty Ronjon
Published: April 2023

Supplementary methods for flow cytometry and retroviral construct generation. Supplementary Figure 1. Expression of activated caspase-3 in CD8+ T cells overexpressing RHEB or PRAS40. Supplementary Figure 2. Expression of CD25 and CD69 in CD8+ T cells overexpressing RHEB or PRAS40. Supplementary Figure 3. Expression of killer cell lectin-like receptor subfamily G member 1 in CD8+ T cells overexpressing RHEB or PRAS40. Supplementary Figure 4. Recall immunity is impaired in CD8+ T cells overexpressing RHEB or PRAS40. Supplementary Figure 5. GFP induction with Doxycycline in CD8+ T cells transduced with iGFP and iPRAS vectors. Supplementary Figure 6. Levels of phosphorylated S6 after stimulation of CD8+ T cells transduced with pMP71-PRAS40 or pMP71-vector control. Supplementary Figure 7. Frequency of CD8+ T cells expressing shRNAs against mTOR or Raptor in peripheral blood 10 days after injection in tumor-bearing hosts.
Supplemental Table 1 from Neutrophil Extracellular Traps Accumulate in Peripheral Blood Vessels and Compromise Organ Function in Tumor-Bearing Animals
Authors: Cedervall Jessica , Zhang Yanyu , Huang Hua , Zhang Lei , Femel Julia , Dimberg Anna , Olsson Anna-Karin
Published: April 2023

Supplemental Table 1: Primers used for q-PCR analysis.
Supplementary Figures 1-9 from Pancreatic Cancer Combination Therapy Using a BH3 Mimetic and a Synthetic Tetracycline
Authors: Quinn Bridget A. , Dash Rupesh , Sarkar Siddik , Azab Belal , Bhoopathi Praveen , Das Swadesh K. , Emdad Luni , Wei Jun , Pellecchia Maurizio , Sarkar Devanand , Fisher Paul B.
Published: April 2023

Supplementary Figures 1-9. Sabutoclax has greater efficacy than ABT-737. (S1) Sabutoclax causes a G1-S phase cell cycle arrest. (S2) Pancreatic cancer cells exhibit varying levels of sensitivity to Minocycline. (S3) Sabutoclax and Minocycline induce cytotoxicity in PANC-1 cells that is reversed with zVAD. (S4) Sabutoclax and Minocycline show synergy. Combination index (CI) values for the combination of Sabutoclax and Minocycline in MIA PaCa-2 cells. (S5) The cytotoxicity induced by Sabutoclax and Minocycline is caspase-dependent and dependent upon loss of Stat3 activation. (S6) Sabutoclax and Minocycline reduce tumor growth in a subcutaneous xenograft model of pancreatic cancer. (S7) Tumors from Pdx-1-Cre/K-rasLSL-G12D/p53flox/wt and Pdx-1-Cre/K-rasLSL-G12D/p53flox/flox mice overexpress Mcl-1 and show sensitivity to Sabutoclax and Minocycline. (S8) Tumors from KPC (Pdx-1-Cre/K-rasLSL-G12D/p53flox/flox )mice treated with Sabutoclax and Minocycline show decreased Stat3 activation. (S9)
Supplementary Methods from HSP90 Supports Tumor Growth and Angiogenesis through PRKD2 Protein Stabilization
Authors: Azoitei Ninel , Diepold Kristina , Brunner Cornelia , Rouhi Arefeh , Genze Felicitas , Becher Alexander , Kestler Hans , van Lint Johan , Chiosis Gabriela , Koren John , Fröhling Stefan , Scholl Claudia , Seufferlein Thomas
Published: April 2023

Supplementary Methods. Description of additional methods and procedures used in the study.
Supplemental Figure Legend from Oncogenic Transformation Can Orchestrate Immune Evasion and Inflammation in Human Mesenchymal Stem Cells Independently of Extrinsic Immune-Selective Pressure
Authors: Miranda Alex , Funes Juan M. , Sánchez Nilda , Limia Celia M. , Mesa Mónica , Quezada Sergio A. , Pérez Rolando , de León Joel
Published: April 2023

Supplemental Figure Legend. Legend for Supplemental Figures S1-S12.
Supplementary Figure S4 from HSP90 Supports Tumor Growth and Angiogenesis through PRKD2 Protein Stabilization
Authors: Azoitei Ninel , Diepold Kristina , Brunner Cornelia , Rouhi Arefeh , Genze Felicitas , Becher Alexander , Kestler Hans , van Lint Johan , Chiosis Gabriela , Koren John , Fröhling Stefan , Scholl Claudia , Seufferlein Thomas
Published: April 2023

Supplementary Figure S4. HSP90 inhibition impairs tumor growth in vivo in a PRKD2-dependent manner.
Supplementary Figure S3 from HSP90 Supports Tumor Growth and Angiogenesis through PRKD2 Protein Stabilization
Authors: Azoitei Ninel , Diepold Kristina , Brunner Cornelia , Rouhi Arefeh , Genze Felicitas , Becher Alexander , Kestler Hans , van Lint Johan , Chiosis Gabriela , Koren John , Fröhling Stefan , Scholl Claudia , Seufferlein Thomas
Published: April 2023

Supplementary Figure S3. Relationship between degradation of AKT1 or RAF1 and killing cancer cells by HSP90 inhibitors.
Supplemental Figure 4 from Evaluating Robustness and Sensitivity of the NanoString Technologies nCounter Platform to Enable Multiplexed Gene Expression Analysis of Clinical Samples
Authors: Veldman-Jones Margaret H. , Brant Roz , Rooney Claire , Geh Catherine , Emery Hollie , Harbron Chris G. , Wappett Mark , Sharpe Alan , Dymond Michael , Barrett J. Carl , Harrington Elizabeth A. , Marshall Gayle
Published: April 2023

Supplemental Figure 4A: Mean FOV and Mean % endogenous gene raw count between the first test (month 0) and the last test (month 9) shown to illustrate effect of storage of a cartridge at 4ºC over a nine month period. Mean raw counts were determined from 2 DLBCL cell line samples HBL-1 and SU-DHL-10 (n=6 each) with a CodeSet consisting of 320 genes including 33 housekeeping genes. Supplemental Figure 4B: Correlation scatter plot of Mean normalised log2 counts between the first test (month 0) and the last test (month 9) (C) shown to illustrate effect of storage of a cartridge at 4ºC over a nine month period. Mean normalised log2 values were determined from 2 DLBCL cell line samples HBL-1 and SU-DHL-10 (n=6 each) with a CodeSet consisting of 320 genes including 33 housekeeping genes.
Supplemental Figure 1 from Evaluating Robustness and Sensitivity of the NanoString Technologies nCounter Platform to Enable Multiplexed Gene Expression Analysis of Clinical Samples
Authors: Veldman-Jones Margaret H. , Brant Roz , Rooney Claire , Geh Catherine , Emery Hollie , Harbron Chris G. , Wappett Mark , Sharpe Alan , Dymond Michael , Barrett J. Carl , Harrington Elizabeth A. , Marshall Gayle
Published: April 2023

Supplemental Figure 1A: Variability due to number of FOV captured. A total of 287 genes were ranked on expression level and grouped as LOW, MEDIUM or HIGH expression for each FOV category. The Standard Deviation (SD) is calculated from mean of 3 fresh clinical DLBCL samples. A sample was determined below LOD if one or both technical replicates were Not-Detected. Data was normalised against 33 housekeeping genes. Supplemental Figure 1B: Reduction in raw counts observed after re-scanning the same cartridge at 280 FOV for a total number of 10 times. The mean % reduction in raw counts of the top positive control spike of 5 independent samples (4 FFPE prostate and UHR) is illustrated. The CodeSet size used was 516 genes including 9 housekeeping genes. Supplemental Figure 1C: Variability due to Cartridge Lane and Analyser Station Slot Position; A human Reference RNA sample was replicated across the 12 lanes of the same cartridge. The cartridge was read at 25 FOV in each of the 6 slots in the Analyser Station. The normalised log2 expression values of a HIGH (mean = 18.1{plus minus}0.14) and a LOW abundance gene (mean = 10.1{plus minus}0.40) are illustrated from a CodeSet consisting of 48 housekeeping genes. Data was normalised against 2 randomly selected housekeeping genes. Supplemental Figure 1D: Correlation scatter plot of normalised log2 counts of representative gastric FFPE sample replicated at 100ng on nCounter GEN1 and GEN2 Prep Stations. Only genes above the LOD are shown from a CodeSet consisting of 506 genes including 8 housekeeping genes.
Supplementary Figure 5 from KAT6B Is a Tumor Suppressor Histone H3 Lysine 23 Acetyltransferase Undergoing Genomic Loss in Small Cell Lung Cancer
Authors: Simó-Riudalbas Laia , Pérez-Salvia Montserrat , Setien Fernando , Villanueva Alberto , Moutinho Catia , Martínez-Cardús Anna , Moran Sebastian , Berdasco Maria , Gomez Antonio , Vidal Enrique , Soler Marta , Heyn Holger , Vaquero Alejandro , de la Torre Carolina , Barceló-Batllori Silvia , Vidal August , Roz Luca , Pastorino Ugo , Szakszon Katalin , Borck Guntram , Moura Conceição S. , Carneiro Fátima , Zondervan Ilse , Savola Suvi , Iwakawa Reika , Kohno Takashi , Yokota Jun , Esteller Manel
Published: April 2023

Supplementary Figure 5. Biochemical and cellular assays to determine KAT6B activity
Supplementary Figure 3 from KAT6B Is a Tumor Suppressor Histone H3 Lysine 23 Acetyltransferase Undergoing Genomic Loss in Small Cell Lung Cancer
Authors: Simó-Riudalbas Laia , Pérez-Salvia Montserrat , Setien Fernando , Villanueva Alberto , Moutinho Catia , Martínez-Cardús Anna , Moran Sebastian , Berdasco Maria , Gomez Antonio , Vidal Enrique , Soler Marta , Heyn Holger , Vaquero Alejandro , de la Torre Carolina , Barceló-Batllori Silvia , Vidal August , Roz Luca , Pastorino Ugo , Szakszon Katalin , Borck Guntram , Moura Conceição S. , Carneiro Fátima , Zondervan Ilse , Savola Suvi , Iwakawa Reika , Kohno Takashi , Yokota Jun , Esteller Manel
Published: April 2023

Supplementary Figure 3. Expression of KAT6B isoforms in SCLC cell lines.
Supplementary Figure S2 from Blocking Tumor Necrosis Factor α Enhances CD8 T-cell–Dependent Immunity in Experimental Melanoma
Authors: Bertrand Florie , Rochotte Julia , Colacios Céline , Montfort Anne , Tilkin-Mariamé Anne-Françoise , Touriol Christian , Rochaix Philippe , Lajoie-Mazenc Isabelle , Andrieu-Abadie Nathalie , Levade Thierry , Benoist Hervé , Ségui Bruno
Published: April 2023

Supplementary Figure S2. Tumor growth of B16-BL6 and Yumm melanoma cell lines in TNF-deficient mice.
Supplementary Figure 2 from KAT6B Is a Tumor Suppressor Histone H3 Lysine 23 Acetyltransferase Undergoing Genomic Loss in Small Cell Lung Cancer
Authors: Simó-Riudalbas Laia , Pérez-Salvia Montserrat , Setien Fernando , Villanueva Alberto , Moutinho Catia , Martínez-Cardús Anna , Moran Sebastian , Berdasco Maria , Gomez Antonio , Vidal Enrique , Soler Marta , Heyn Holger , Vaquero Alejandro , de la Torre Carolina , Barceló-Batllori Silvia , Vidal August , Roz Luca , Pastorino Ugo , Szakszon Katalin , Borck Guntram , Moura Conceição S. , Carneiro Fátima , Zondervan Ilse , Savola Suvi , Iwakawa Reika , Kohno Takashi , Yokota Jun , Esteller Manel
Published: April 2023

Supplementary Figure 2. Copy number and expression levels of six KATs in SCLC cell lines
Supplementary Methods and References from SOCS2 Controls Proliferation and Stemness of Hematopoietic Cells under Stress Conditions and Its Deregulation Marks Unfavorable Acute Leukemias
Authors: Vitali Caterina , Bassani Claudia , Chiodoni Claudia , Fellini Elisa , Guarnotta Carla , Miotti Silvia , Sangaletti Sabina , Fuligni Fabio , De Cecco Loris , Piccaluga Pier P. , Colombo Mario P. , Tripodo Claudio
Published: April 2023

Supplementary Methods and References. Description of additional methods and procedures used in the study. Also includes Supplementary References.
Supplemental Figure S4 from KRAS Genomic Status Predicts the Sensitivity of Ovarian Cancer Cells to Decitabine
Authors: Stewart Michelle L. , Tamayo Pablo , Wilson Andrew J. , Wang Stephanie , Chang Yun Min , Kim Jong W. , Khabele Dineo , Shamji Alykhan F. , Schreiber Stuart L.
Published: April 2023

A, CRAF-amplifed melanoma cancer cell line (A375) was pre-treated with decitabine (0.5 ÃŽÂ¼M) or DMSO for three, six or nine days followed by co-treatment of viable cells for three additional days with decitabine (0.5 ÃŽÂ¼M) or DMSO and small molecule inhibitors, GDC-0941, bortezomib or NVP-TAE684 (two biological replicates, mean {plus minus} SD). B, A375 cells were pre-treated as described above, followed by co-treatment with decitabine and navitoclax, trametinib or selumetinib for three additional days. Data is a representative example of two independent experiments.
Supplemental Figure S1 from KRAS Genomic Status Predicts the Sensitivity of Ovarian Cancer Cells to Decitabine
Authors: Stewart Michelle L. , Tamayo Pablo , Wilson Andrew J. , Wang Stephanie , Chang Yun Min , Kim Jong W. , Khabele Dineo , Shamji Alykhan F. , Schreiber Stuart L.
Published: April 2023

Cell viability is shown for sensitive (IC50 < 150 nM, red) and resistant (IC50 > 150 nM, blue) cell lines after nine days of treatment with decitabine. KRAS mutation status is marked with an asterisk (*). Data are representative of two independent experiments each measured in 14 replicates (mean, error bars removed for clarity).
Supplementary Figure S4 from A Molecular Portrait of High-Grade Ductal Carcinoma In Situ
Authors: Abba Martin C. , Gong Ting , Lu Yue , Lee Jaeho , Zhong Yi , Lacunza Ezequiel , Butti Matias , Takata Yoko , Gaddis Sally , Shen Jianjun , Estecio Marcos R. , Sahin Aysegul A. , Aldaz C. Marcelo
Published: April 2023

Supplementary Figure S4: SOX10, SOX15 and SOX17 mRNA expression among normal and invasive breast carcinomas from TCGA dataset classified according the intrinsic subtypes.
Supplementary Figure S7 from G-CSF Promotes Neuroblastoma Tumorigenicity and Metastasis via STAT3-Dependent Cancer Stem Cell Activation
Authors: Agarwal Saurabh , Lakoma Anna , Chen Zaowen , Hicks John , Metelitsa Leonid S. , Kim Eugene S. , Shohet Jason M.
Published: April 2023

Supplementary Figure S7. STAT3 knockdown analysis in human neuroblastoma cell lines.