bluuebunny/crossref_metadata_2025 huggingface dataset:
(Neutrosophic) 1-Failed SuperHyperForcing in Cancer’s Recognitions And (Neutrosophic) SuperHyperGraphs
Authors: Garrett Henry
Published: January 2023

In this research, new setting is introduced for new SuperHyperNotions, namely, an 1-failed SuperHyperForcing and Neutrosophic 1-failed SuperHyperForcing. Assume a SuperHyperGraph. Then an ``1-failed SuperHyperForcing'' $\mathcal{Z}(NSHG)$ for a neutrosophic SuperHyperGraph $NSHG:(V,E)$ is the maximum cardinality of a SuperHyperSet $S$ of black SuperHyperVertices (whereas SuperHyperVertices in $V(G) \setminus S$ are colored white) such that $V(G)$ isn't turned black after finitely many applications of ``the color-change rule'': a white SuperHyperVertex is converted to a black SuperHyperVertex if it is the only white SuperHyperNeighbor of a black SuperHyperVertex. The additional condition is referred by ``1-'' about the usage of any black SuperHyperVertex only once to act on white SuperHyperVertex to be black SuperHyperVertex; a ``neutrosophic 1-failed SuperHyperForcing'' $\mathcal{Z}_n(NSHG)$ for a neutrosophic SuperHyperGraph $NSHG:(V,E)$ is the maximum neutrosophic cardinality of a SuperHyperSet $S$ of black SuperHyperVertices (whereas SuperHyperVertices in $V(G) \setminus S$ are colored white) such that $V(G)$ isn't turned black after finitely many applications of ``the color-change rule'': a white SuperHyperVertex is converted to a black SuperHyperVertex if it is the only white SuperHyperNeighbor of a black SuperHyperVertex. The additional condition is referred by ``1-'' about the usage of any black SuperHyperVertex only once to act on white SuperHyperVertex to be black SuperHyperVertex. Assume a SuperHyperGraph. Then an ``$\delta-$1-failed SuperHyperForcing'' is a \underline{maximal} 1-failed SuperHyperForcing of SuperHyperVertices with \underline{maximum} cardinality such that either of the following expressions hold for the (neutrosophic) cardinalities of SuperHyperNeighbors of $s\in S:$ $~|S\cap N(s)| > |S\cap (V\setminus N(s))|+\delta,~|S\cap N(s)| < |S\cap (V\setminus N(s))|+\delta.$ The first Expression, holds if $S$ is an ``$\delta-$SuperHyperOffensive''. And the second Expression, holds if $S$ is an ``$\delta-$SuperHyperDefensive''; a``neutrosophic $\delta-$1-failed SuperHyperForcing'' is a \underline{maximal} neutrosophic 1-failed SuperHyperForcing of SuperHyperVertices with \underline{maximum} neutrosophic cardinality such that either of the following expressions hold for the neutrosophic cardinalities of SuperHyperNeighbors of $s\in S:$ $~|S\cap N(s)|_{neutrosophic} > |S\cap (V\setminus N(s))|_{neutrosophic}+\delta,~ |S\cap N(s)|_{neutrosophic} < |S\cap (V\setminus N(s))|_{neutrosophic}+\delta.$ The first Expression, holds if $S$ is a ``neutrosophic $\delta-$SuperHyperOffensive''. And the second Expression, holds if $S$ is a ``neutrosophic $\delta-$SuperHyperDefensive''. A basic familiarity with SuperHyperGraph theory and neutrosophic SuperHyperGraph theory are proposed.
Collagen Alpha 1(XI) Is Required for Chondrocyte Differentiation through the AKT/GSK3 β/β-Catenin Signaling Axis in ATDC5 Cells
Authors: Reeck Jonathon C. , Oxford Julia Thom
Published: January 2023

Cartilage development is a tightly regulated process that involves multiple molecules and signaling pathways. The loss of expression of a single gene can alter cell behavior and disrupt the development of the cartilage. Col11a1 encodes the alpha one chain of the minor fibrillar collagen type XI that is essential in skeletal development. We used an RNAi mediated knockdown approach to investigate the role of Col11a1 expression during chondrogenesis in ATDC5 cells. Col11a1 expression promotes the transition of mesenchymal cells to the chondrogenic phenotype, and reduction of Col11a1 expression interferes with cellular differentiation. Our results indicate that collagen α1(XI) protein is required for chondrocyte cell shape, matrix production, mineralization and gene expression through a mechanism that involves AKT/GSK3β/β-catenin and TCF/LEF activity in ATDC5 cells.
Exploring Skills in Observing Teaching Competency through Video Evaluation of Class Demonstrations by Pre-service Physical Education Teachers
Authors: Kim Chul-min , Kim Min-jun , Youn Hyun-su , Jung Joo-Hyug
Published: January 2023

This study aimed to evaluate the level of skill in observing teaching competency in pre-service physical education (PE) teachers and provide basic data to cultivate teaching competency. A total of 21 third-year pre-service PE teachers were selected as participants. The study derived descriptive statistics to analyze the participants’ observation skills regarding teaching competency in different class stages using evaluation results of class demonstrations by pre-service teachers. Mann–Whitney U test was conducted to verify the statistical significance of the evaluation between in-service and pre-service teachers. Compared with in-service teachers, pre-service teachers reported high agreement with intuitive teaching behaviors. However, pre-service teachers indicated low agreement with skills that required complex teaching behaviors depending on various situations. Based on theories by Schon (1983), pre-service teachers showed high “knowledge for practice” and low “knowledge in practice.” Thus, pre-service education must balance practical knowledge and theory rather than focus on theory-based education. This study provided directions for pre-service teacher education to enhance the competency of pre-service teachers for leading and analyzing classes.
Recent Trends in Antisense Therapies for Duchenne muscular dystrophy
Authors: Wilton-Clark Harry , Yokota Toshifumi
Published: January 2023

Duchenne muscular dystrophy (DMD) is a debilitating and fatal genetic disease affecting 1/3500 boys globally, characterized by progressive muscle breakdown and eventual death with an average lifespan in the mid-late twenties. While no cure yet exists for DMD, gene and antisense therapies have been heavily explored in recent years to better treat this disease. Four antisense therapies have received conditional FDA approval, and many more exist in varying stages of clinical trials. These upcoming therapies often utilize novel drug chemistries to address limitations of existing therapies, and their development could herald the next generation of antisense therapy. This review article aims to summarize the current state of development for antisense-based therapies for the treatment of Duchenne muscular dystrophy, exploring candidates designed for both exon skipping and gene knockdown.
Adaptive Parametric Identification of Systems with Multiple Nonlinearities
Authors: Karabutov Nikolay
Published: January 2023

The system identification problem with multiple nonlinearities is relevant. Its decision depends on many factors. These include: feedbacks, the method of connecting nonlinear links, signal properties. They affect the identifiability of the system parameters. We introduced a condition for the excitation constancy for state variables, which considers the S-identifiability of the system. We propose system decomposition by measuring input to identify parameters. Each subsystem has an implicit identification representation. It guarantees obtaining estimates of subsystem parameters based on experimental data. The trajectories boundedness of adaptive system proved in parametric and coordinate spaces. Conditions guaranteeing exponential stability of the system obtained. Systems of self-oscillation generation and nonlinear correction of a nonlinear system consider. Conditions for the trajectories boundedness of the adaptive system obtained for these cases. The influence of nonlinearity and feedback on the system performance estimated.
Relationship between Joint and Ligament Structures of the Subtalar Joint and Degeneration of the Subtalar Articular Facet
Authors: Togashi Ryoya , Edama Mutsuaki , Shagawa Mayuu , Osanami Haruki , Yokota Hrotake , Hirabayashi Ryo , Sekine Chie , Ishigaki Tomonobu , Akuzawa Hiroshi , Yamada Yuki , Toriumi Taku , Kageyama Ikuo
Published: January 2023

This study aimed to clarify the relationship between the joint and ligament structures of the subtalar joint and degeneration of the subtalar articular facet. We examined 50 feet from 25 Japanese cadavers. The number of articular facets, joint congruence, and intersecting angle were measured for the joint structure of the subtalar joint, and the footprint areas of the ligament attachments of the cervical ligament, interosseous talocalcaneal ligament (ITCL), and anterior capsular ligament were measured for the ligament structure. Also, subtalar joint facets were classified into Degeneration (+) and (-) groups according to degeneration of the talus and calcaneus. No significant relationship was identified between the joint structure of the subtalar joint and degeneration of the subtalar articular facet. In contrast, footprint area of the ITCL was significantly higher in the Degeneration (+) group than in the Degeneration (-) group for the subtalar joint facet. These results suggest that the joint structure of the subtalar joint may not affect degeneration of the subtalar articular facet. Degeneration of the subtalar articular facet may be related to the size of the ITCL.
Altered Mesenchymal Stem Cells Mechanotransduction from Oxidized Collagen. Morphological and Biophysical Observations
Authors: Komsa-Penkova Regina , Yordanova Adelina , Tonchev Pencho , Kyurkchiev Stanimir , Todinova Svetla , Strijkova Velichka , Iliev Mario , Dimitrov Borislav , George Altankov
Published: January 2023

ECM provides various mechanical cues that are able to affect the self‑renewal and differentiation of mesenchymal stem cells (MSC). Little is known however how these ques work in a pathological environment, such as acute oxidative stress. To better understand the behavior of human adipose tissue-derived MSC (ADMSC) in such conditions here we provide morphological and quantitative evidence for significantly altered early steps of mechanotransduction when adhering to oxidized collagen (Col-Oxi). This affects both focal adhesion (FA) formation and YAP/TAZ signaling events. Representative morphological images show that ADMSCs spread better within 2 h of adhesion on native collagen (Col), while they tended to round up on Col-Oxi. It correlates also with the less development of the actin cytoskeleton and FA formation, confirmed quantitatively by morpho-metric analysis using ImageJ. As shown by immunofluorescence analysis, oxidation also affected the ratio of cytosolic to nuclear YAP/TAZ activity, concentrating in the nucleus for Col while remaining in the cytosol for Col-Oxi, suggesting abrogated signal transduction. Comparative AFM studies show that native collagen forms relatively coarse aggregates, much thinner with Col-Oxi, possibly reflecting its altered ability to aggregate. On the other hand, the corresponding Young's moduli were only slightly changed, so viscoelastic properties cannot explain the observed biological differences. However, the roughness of the protein layer decreases dramatically, from RRMS equal to 27.95 + 5.1 nm for Col to 5.51 + 0.8 nm for Col-Oxi (p<0.05), which dictates our conclusion that it is the most altered parameter in oxidation. Thus, it appears to be a predominantly topo-graphic response that affects the mechanotransduction of ADMSCs by oxidized collagen.
Performance of a 7-type HPV mRNA Test in Triage of HPV DNA Primary Screen Positive Women Compared to Liquid-based Cytology
Authors: Sørbye Sveinung Wergeland , Falang Bente Marie , Antonsen Mona
Published: January 2023

Background: A plethora of data supports HPV-based screening to be the preferred strategy for cervical cancer prevention. The shift to a more sensitive firstline test brings the need of effective triage up for discussion. Currently, most algorithms apply cytology as triage of HPV-DNA positive women. This study compared the performance of a 7-type HPV-mRNA test to cytology. Methods: From 2019-01-01, until 2021-12-31, cervical samples from 58,029 women were examined at the University Hospital of North Norway. 30.5% (17,684/58,029) fulfilled the criteria for HPV-DNA primary screening. All positive samples were triaged by cytology and followed-up according to national guidelines. Additionally, a 7-type HPV-mRNA test was applied. Study endpoint was histologically confirmed high grade lesion (CIN2+). Results: 5.6% (990/17,684) had positive HPV-DNA test, 97.2% (962/990) with valid HPV-mRNA results. 55.5% (534/962) had abnormal cytology (ASC-US+) and 35.1% (338/962) had positive HPV-mRNA test. 9.8% (94/962) had CIN2+. Sensitivity (CIN2+) of cytology versus the HPV-mRNA test was 83.0% (78/94) versus 76.6% (72/94), p=0.36. The specificity was 47.5% (412/868) versus 69.4% (602/868), p<0.001. PPV was 14.6% (78/534) and 21.3% (72/338), p=0.014 respectively. The number of colposcopies per CIN2+ detected by cytology and HPV-mRNA test was 6.8 and 4.7. Conclusion: The 7-type HPV mRNA test was more specific than cervical cytology in triage of HPV-DNA positive women. Using this biomarker as threshold for colposcopy may better balance the benefits and harms of screening.
Vocational High School Teacher's Work Ethic
Authors: Sitanggang Nathanael , Luthan Putri Lynna Adelinna
Published: January 2023

Essential research describes the work ethic of Vocational High School teachers and the indicator that mostly affects the formation of the latent variable of the vocational teacher's work ethic. The research used a survey method with a sample consisting of 212 SMK teachers in Medan. The analytical technique used was a confirmatory factor analysis with SEM analysis using AMOS tools. The analysis revealed that the SMK teachers’ work ethic reached 35.85%, categorised as high, 52.36% as adequate, 8.49% as inadequate, and 3.30% as low. It also showed that an indicator variable of having a preference for working hard served as the strongest indicator (52.70%) that formed the latent construct variable of the vocational teachers' work ethic. Subsequently, the latent construct variables of vocational teachers' work ethic contain several indicators that include a preference for working hard at 52.70%; willingness to give more than required at 50.55%; fairness at 49.14%; willingness to cooperate at 48.86%; working honestly with 42.64%; work efficiently during working hours with 39.18%; and respecting colleagues with 25.60%.
Evaluation of Learning in Civil Engineering Study Program Groups in the Field of Science and Environment in the 21st Century Learning System
Authors: Purwaamijaya Iskandar Muda , Masri Rina Marina
Published: January 2023

This article aims to evaluate group learning in the field of Civil Engineering and environmental science in the 21st-century learning system. The 21st-century learning system is designed for the 21st-century generation to keep up with the latest technological developments. Survey and mapping learning systems in pandemic conditions have adopted and implemented 21st-century learning systems, but detailed and precise information has not been studied. The research method used is the descriptive quantitative method. The participants of this study are Civil Engineering students. The pretest and posttest questions were used to collect data related to the comprehension test by giving a test via the google form link. The results showed an increase in understanding of the 21st-century learning system. The value of Civil Engineering students' knowledge about the 21st-century learning system increased. This illustrates that delivering material about the 21st-century learning system is quite successful. Thus, there is a need for advanced research on 21st-century learning related to personnel, equipment, and funding.
Legal Protection of Stateless Persons Arising From Cross-Border Marriage: Case of Indonesia – East Timor
Authors: Trihastuti Nanik , Indreswari Tri Laksmi , Kandou Daniel René , Ardani Mira Novana , Ramadhan Diastama Anggita
Published: January 2023

Statelessness is a continuing international legal issue, with individuals lacking the protection of fundamental rights within the jurisdiction of a State. One aspect contributing to this problem is customary cross-border marriage between people of different nationalities, particularly in local border towns, for a variety of reasons. This study examines the phenomenon as a cause of statelessness and undocumented individuals and what the legal protection that international human rights instruments provide for States to comply. This study uses legal research by comparing the East Timor Constitution. Based on the study's results, the potential for statelessness and undocumented people due to cross-border marriage by custom has a detrimental effect on both women and children since it is difficult for them to obtain residence documents. Cross-border marriages between East Timorese men and Indonesian women by customary causing unregistered in Indonesia and East Timor. Field research shows that Indonesian women/wives in East Timor cannot exercise their rights since they are not East Timorese nationals. Noting the conflict of nationality laws between States, especially bordering States, the failure of both States to accommodate women that married are non-nationals breaches Article 9 of CEDAW and constitutes as discrimination against women defined under Article 1 of CEDAW
Clinical Efficacy and Tolerability of Antihypertensive Therapy with Single Pill Combinations of Telmisartan in Patients with Arterial Hypertension in Clinical Practice According to the ON TIME Observational Study
Authors: Ageev F. T. , Smirnova M. D.
Published: January 2023

Aim. To assess the clinical outcomes and tolerability of antihypertensive therapy with single pill combinations (SPC) amlodipine + telmisartan and hydrochlorothiazide + telmisartan in clinical practice.

Material and methods. Patients with hypertension of grade 1-3 (n=13647; 57.6% women; age 59.3±11.4 years) who received therapy with SPC amlodipine + telmisartan or hydrochlorothiazide + telmisartan were included in an observational multicenter study. Information on complaints, history, previous therapy, history of novel coronavirus infection (COVID-19) during the previous year was obtained. Also, measurement of height, body weight, waist circumference (WC) and hips (HC), office blood pressure (BP) three times with an interval of 4 weeks, completion of questionnaires of satisfaction with therapy using the Likert scale, and assessement of adherence to therapy according to the patient's opinion was performed.

Results. A statistically significant decrease in systolic (SBP) and diastolic blood pressure (DBP) was found both in all patients and in the analysis of subgroups according to the grade of hypertension (p<0.001 between visits in all cases). The degree of BP reduction depended on baseline BP levels. The average decrease in SBP/DBP at the 3rd visit for the grade 1 hypertension was 24.5/14.6 mm Hg, for the grade 2 hypertension – 34.4/16.8 mmHg, for the grade 3 hypertension – 49.6/22.1 mmHg (p<0.001 between groups). Target levels of SBP (≤140 mmHg) and DBP (≤90 mmHg) were achieved in 95.3% and 98.1% of patients, respectively. Target levels of SBP (≤130 mmHg) and DBP (≤80 mmHg) were achieved in 74.9% and 78.2% of patients, respectively. WC decreased by 0.5%; HC – by 1.5%; body weight – by 0.42% (p<0.001 in all cases). Scores in patients with a history of COVID-19 did not differ from those in individuals without a history of COVID-19. There were no violations of the therapy regimen during the observation period in 94% of patients. Most doctors and patients were "satisfied" or "completely satisfied" with the clinical effect, convenience and tolerability of therapy. Adverse events occurred in 1.35% of patients.

Conclusion. Therapy with SPC amlodipine + telmisartan or hydrochlorothiazide + telmisartan in clinical practice had a high antihypertensive efficacy and had an optimal safety profile. The efficacy of therapy did not depend on the initial grade of hypertension, as well as the past infection with COVID19. The results of the ON TIME study confirm the feasibility of using the SPC amlodipine + telmisartan and hydrochlorothiazide + telmisartan for a wide range of hypertensive patients.
A Case Report of Differential Diagnosis of Causes of Severe Valvular Heart Disease (Takayasu's Arteritis, Infective Endocarditis and Myxomatous Degeneration) with the Key Role of Histological and PCR Examination
Authors: Pisaryuk A. S. , Kotova E. O. , Ageev P. V. , Moiseeva A. Yu. , Povalyaev N. M. , Domonova E. A. , Silveistrova O. Yu. , Tsimbalist N. S. , Babukhina Ju. I. , Meray I. A. , Kakhktsyan P. V. , Meshkov A. D. , Safarova A. F. , Kobalava Zh. D.
Published: January 2023

Aortic valve lesion is a common and may have diverse causes, from degenerative, congenital and infectious diseases to autoimmune conditions. We present a rare case of Takayasu arteritis and severe heart lesion due to the myxomatous degeneration of the aortic and mitral valves associated with development of infective endocarditis (IE) complicated by abscess, fistula, valve perforation and recurrent acute decompensated heart failure in a young female patient. A combined use of histopathological and PCR analyses of valve tissues was critically important for differential diagnosis of the valve lesions, as it made it possible to identify the true cause of the disease. The presence of Takayasu arteritis has played an indirect role by creating conditions for the development of immunosuppression and determining the disease severity and its progression.
Juridical Review of the Right to Restitution, Rehabilitation, and Compensation for Victims of the Crime of Trafficking in Persons according to Law No. 21 of 2007 on Court Decisions
Authors: Putri Syntia Puspita Andini Ika Hariyanto , Rosnawati Emy
Published: January 2023

The two continents and oceans around Indonesia make Indonesia in the position of international shipping trade routes. However, in the geographical location of the State of Indonesia, it is threatened to become a traffic lane for crime. Trafficking in people or persons is not only a domestic concern, but is a universal problem that is increasing every year. The purpose of this research is to find out or provide knowledge about the fulfillment of restitution rights and rehabilitation rights, and compensation for victims of trafficking in persons which are criminal acts in court decisions. Normative juridical law is the method used by the author in this study. This study provides results that the right to rehabilitation, restitution, and compensation for victims of the Criminal Act of Trafficking in Persons in Decision No. 257/Pid.Sus./2019/PN SDA and Decision No. 889/Pid.Sus/2018/PN SDA according to the Law No. 21 of 2007 was not implemented or not applied by the Panel of Judges.
The Effect of Earnings Management, Capital Intensity, Firm Size, Fiscal Loss Compensation on Tax Avoidance
Authors: Nisa Khoirun , Ernandi Herman
Published: January 2023

Effect of Earnings Management, Capital Intensity, Firm Size, and Fiscal Loss Compensation on Tax Avoidance (Study on Food and Beverage Companies listed on the Indonesia Stock Exchange in 2015-2019). This study aims to obtain evidence on the effect of earnings management, firm size, capital intensity, and compensation for tax losses on tax avoidance. In this study, using purposive sampling method to show the sample. The population in this thesis are manufacturing companies with the food and beverage sector with a population of 80 companies listed on the Indonesia Stock Exchange (IDX). With the selection of criteria, there is a total sample of 16 companies in an observation period of 5 years starting from 2015-2019. In this observation, tax avoidance is calculated through the formulation of the ETR. The tester for the hypothesis in this observation uses multiple regression analysis techniques. The results of this observation show that earnings management, firm size, and tax loss compensation affect tax avoidance. But capital intensity can not affect tax avoidance.
Analysis of the Effect of Liquidity, Profitability and Debt Policy on Firm Value with Dividend Policy as Moderating Variable
Authors: Wanti Fadilah Herdiana , Sari Herlinda Maya Kumala
Published: January 2023

The purpose of this study is to analyze the effect of liquidity, profitability, and debt policy on firm value with dividend policy as a moderating variable on LQ45 index companies listed on the Indonesia Stock Exchange for the 2018-2020 period. This study is a quantitative study using purposive sampling technique with a sample of 14 companies from a population of 62 companies and tested by multiple linear regression analysis and MRA (Moderated Regression Analysis) using SPSS version 22 software. The results showed that liquidity (CR) had a significant negative effect. on firm value (PBV), profitability (ROA) has a significant positive effect on firm value (PBV), debt policy (DER) has no effect on firm value (PBV), dividend policy (DPR) is able to moderate by significantly weakening the effect of liquidity (CR ) on firm value (PBV), dividend policy (DPR) is able to moderate by significantly strengthening the effect of profitability (ROA) on firm value (PBV) and dividend policy (DPR) is not able to significantly moderate the effect of debt policy (DER) on firm value. (PBV).
The Influence of Tax Understanding, Taxpayer Awareness and the E-Samsat System in the Covid-19 Era on the Implementation of Motor Vehicle Tax Payments Instructions in Sidoarjo
Authors: Safrida Harli Aulia
Published: January 2023

This study aims to clarify and understand the meaning of taxation, taxpayer awareness and the use of the ESamsat system for payment of vehicle taxes in the Sidoarjo area during the covid19 pandemic. This research is based on motor vehicle tax revenues that are not yet optimal. This research method uses quantitative data collection by distributing 100 questionnaires to respondents from all vehicle taxpayers in the Sidoarjo area. This study states that the results of tax understanding (X1) have a positive effect on the implementation of vehicle tax payments (Y) and taxpayer awareness (X2) has a negative effect on the implementation of vehicle tax payments (Y) and the E-Samsat system in the Covid19 era (X3). positive effect on the implementation of motor vehicle tax payments (Y).
The Influence of Organizational Culture Leadership Style and Work Stress on Commitment
Authors: Susilo Agil Panji , Indayani Lilik
Published: January 2023

This study aims to determine the effect of Leadership Style, Organizational Culture and Work Stress on Organizational Commitment at PT. Ciomas Adisatwa Sidoarjo. This research is a type of quantitative research with hypothesis testing. The sample used in this study are employees of PT. Ciomas Adisatwa F&A, P&GA, Purchasing and Ppic divisions, totaling 39 employees. This study uses quantitative data analysis techniques. Descriptive statistical analysis and inferential statistical analysis were used to analyze quantitative data. The analytical tool used in this research is SPSS Software. The data used in this study are questionnaire data and data sourced from PT. Ciomas Adiasatwa Sidoarjo. Data collection techniques using questionnaires, interviews and observations. The results of this study prove that Hypothesis 1: Leadership Style Variable has a significant and positive effect on Organizational Commitment. Hypothesis 2: Organizational Culture Variable has a significant and positive effect on Organizational Commitment. Hypothesis 3: Work Stress Variable has a significant and negative effect on Organizational Commitment. Hypothesis 4: Leadership Style, Organizational Culture and Work Stress Together have an effect on organizational commitment.
The Influence of Product Design, Brand Image and Product Quality on Purchase Decisions on Oppo Brand Mobile Products
Authors: Hidayat Rahmat , Indayani Lilik
Published: January 2023

This study aims to determine that product design, brand image and product quality influence purchasing decisions on Oppo brand mobile phones. This study uses quantitative research with hypothesis testing. The sampling technique used in this study used a non-probability sampling technique with an accidental sampling method of 96 respondents. And the data analysis technique uses data quality test, classical assumption test, and multiple linear regression analysis. The results of this study indicate that product design and product quality have a significant effect on purchasing decisions, while brand image has no effect on purchasing decisions.
Building Productive Behavior with Leadership, Interpersonal Communication and Organizational Climate as Intervening Variables
Authors: Maulana Emerald Rafif , Abadiyah Rifdah
Published: January 2023

Human resources are productive individuals who act as organizational drivers with asset functions in both organizations and companies, so training and skills development are needed. To train skills that meet the needs of the company, a human resource management strategy is needed that will bring progress and change to the company. This study aims to examine the effect of leadership and interpersonal communication on employee productive behavior through organizational climate as an intervening variable at Gubug Makan Mangengking Surabaya. This research is a type of quantitative research with hypothesis testing. The sample used in this study were 60 employees of Gubug Makan Mangengking Surabaya. The analytical tool used in this research is SPSS. The results of this study prove that Leadership has an effect on Organizational Climate, Interpersonal Communication has an effect on Organizational Climate, Leadership has an effect on Employee Productive Behavior, Interpersonal Communication has an effect on Employee Productive Behavior, Organizational Climate has an effect on Employee Productive Behavior, Leadership has an effect on Employee Productive Behavior mediated by Organizational Climate, Interpersonal Communication has an effect on Employee Productive Behavior mediated by Organizational Climate. The benefits of research for science are that it adds knowledge and provides an opportunity for writers to apply the knowledge of personnel that has been studied so far. Keywords: Leadership, Interpersonal Communication, Employee Productive Behavior and Organizational Climate.
The Effect of Product Innovation, Brand Image, and Utilization of E-Commerce on Consumer Purchase Decisions
Authors: Bahalwan Faiz , Indayani Lilik
Published: January 2023

This study aims to determine that product innovation, brand image, and e-commerce have a simultaneous effect on consumer purchasing decisions. In mid-March 2020 the whole world was struck by a calamity. This disaster is known as the Covid-19 pandemic. All existing sectors have had a negative impact due to the Covid-19 pandemic, one of which is the economy. Where MSME traders who sell online are also affected by the Covid-19 pandemic. The income they receive is drastically reduced, eventually resulting in bad effects for the sustainability of their business. The problem in this study is that there are differences between previous research and the research that will be carried out. In this study using quantitative methods. According to Zechmester (2000) quantitative research can be regarded as a method that describes a study whose assessment focuses on the relationship between variables that arise naturally. Meanwhile, the data analysis technique used in this research is data quality test, classical assumption test, and multiple linear regression analysis. The results show that Product Innovation has a significant effect on consumer purchasing decisions. Brand Image has no effect on consumer purchasing decisions. E-Commerce has an effect on consumer purchasing decisions.
The Effect of Culture Characteristics, Commitment, and Organizational Communication on Employee Performance at Educational Institutions.
Authors: Fikri Syamsur Rizalul , Ubaidillah Hasan
Published: January 2023

This study aims to determine the effect of cultural characteristics, commitment, and organizational communication on the performance of employees of the Independent Cendekia Insan Educational Institution. The analytical tool used is tabulating the questionnaire, collecting data in the form of validity testing and reliability testing. The hypotheses in this study were tested using classical assumption analysis, multiple linear regression, coefficient of determination (R2), partial correlation coefficient, t test, F test and test using SPSS software for Windows version 18. The results of this study resulted in several conclusions, namely: ( 1) There is a simultaneous influence of organizational culture characteristics, Commitment, and Communication on employee performance (2) There is a partial influence of organizational culture, Commitment, and Communication characteristics on managerial performance (3) Among the characteristics of organizational culture, Commitment, and Communication, cultural characteristics organization has the most significant effect on employee performance.
Juridical Overview of the Application of the Caning Law in the Province of Nanggroe Aceh Darussalam from the Human Rights Perspective
Authors: Mardiana Nana , Rosnawati Emy
Published: January 2023

This study aims to describe and explain the application of caning in Aceh in terms of human rights. Since the issuance of the legal instrument of Aceh Qanun Number 6 of 2014 there have been pros and cons in the community regarding this punishment. This research method uses normative or doctrinal, the data collection process is carried out by reviewing literature that is relevant to the problems written by the author. The result of this research is that the caning punishment in Aceh cannot be said to violate human rights. Because in its implementation it is very concerned about the safety aspect for convicts of whipping. In contrast to imprisonment, the caning sentence after the execution process of the convict can immediately return to normal activities and caning can teach the community not to commit violations.
The Influence of Business Location, Price, and Consumer Satisfaction on Buying Interest in Stores
Authors: Andani Retno , Oetarjo Mas
Published: January 2023

In an effort to bring in new customers and also retain customers, it requires high buying interest from consumers who ultimately make purchasing decisions. There are several factors that must be considered by entrepreneurs in starting a business, namely to coincide with the selection of location, price, and consumer satisfaction. To find out that the location of the business affects the interest in buying in Pak Tris 5758 Stores. This research uses quantitative methods. Sampling in this study used incidental sampling methods in consumers of Pak Tris 5758 Stores, namely consumers who shop at Pak Tris 5758 Stores, with a total of 96 respondents. The data collection technique used is to use kuesioner. The data analysis technique in this study uses multiple linear regression through the SPSS Statistic program version 22.  The results showed that Business Location (X1), Price (X2), and Consumer Satisfaction (X3) simultaneously affect Buying Interest (Y) in Pak Tris 5758 Stores. Business Location (X1) partially affects Buying Interest (Y), Price (X2) partially affects Buying Interest (Y) and Consumer Satisfaction (X3) partially affects Buying Interest (Y).
The Influence of Consumer Focus, Operational Focus on Business Results of Cafe and Warkop Angkringan Owners in East Java
Authors: Nugroho Brilian , Sukmono Rita Ambarwati
Published: January 2023

The purpose of this study was to determine the effect of consumer focus, operations focus on business results on cafe owners and Angkringan Warkop owners in East Java. This research is a descriptive study using quantitative methods. Probability sampling technique to determine the population, and using accidential sampling for sampling. for the number of samples in this study took as many as 150 respondents to be the research sample. Then the validity test and reliability test will be carried out by using the Smart PLS method as a data processing application to conclude the proposed hypothesis and to answer the problem formulation. The results of this study, show results that can prove that Consumer Focus, Operations Focus has an effect on Business Results owners of Cafes and Warkop Angkringan in East Java.
The Influence of Celebrities/Celebrities Endorsers and Shopee E-Commerce on Consumer Purchase Interests of Products
Authors: Ardiansah Fani , Rocmaniah Ainur
Published: January 2023

The study aims to determine the effect of Selebgram/Celebrity Endorser and E-Commerce Shopee on consumer buying interest of Erigo product. The method used in this research is quantitative. The populations in this study were Instagram followers @erigostore with a sample of 205 respondents who were taken using the Slovin Formula’s and using a simple random sampling technique. Data collection is done by ditributing questioners with the help of google form. This study uses multiple linier regression, and data analysis with the help of SPSS 20.0 software. The result of this study indicate that there is an influence of Selebgram/Celebrity Endorser and E-Commerce Shopee on consumer buying interest with an Adjusted R Square value of 0,489 with a contribution of 48,9% independent variables. There result of the T Test show that there is a parsial effect of Selebgram/Celebrity Endorser and E-Commerce Shopee on consumer buying interest in Erigo products. And the result of the F Test shiow the influence of Selebgram/Celebrity Endorser and E-Commerce Shopee on consumer buying interest in Erigo products together or simultan
Analysis Of Discipline, Organizational Culture and Public Service Performance
Authors: Adi Sujito Nazelia Lestari , Firdaus Vera
Published: January 2023

This study aims to examine the influence of the work environment, work discipline, and organizational culture on employee performance. This study uses a quantitative approach with a descriptive method. The sampling technique used was proportional stratified random sampling. The sample used in this study amounted to 236 employees. Data analysis techniques used the SPSS Statistical Package for the Social Sciences
The Effect of Authoritarian Leadership Style, Work Motivation, and Discipline on Employee Loyalty
Authors: Purnami Charina Laras , Indayani Lilik
Published: January 2023

This research was conducted with the aim of knowing the influence of leadership styleauthoritarian, work motivation, and discipline partially and simultaneously to loyaltyemployees at PT. Jayaland Hills Rays. This study uses a quantitative approach with questionnaire data collectiondistributed to 185 respondents. Samples are taken based on o`ne of the techniquesnon-probability sampling , the type of which is purposive sampling. Technical analysis of the data using the test instrument statement on the questionnaire (test validity,and reliability), classical assumption test (normality, linearity, multicollinearity, autocorrelation and heteroscedasticity) and multiple linear regression (multiple correlation test, multiple determination test,partial test and simultaneous test). The results obtained from this study are that there is an influence of leadership styleauthoritarian, work motivation, and discipline partially and simultaneously to loyaltyemployees at PT. Jayaland Hills Ray.
Analysis of the Influence of Organizational Culture, Competence, and Employee Welfare on Organizational Citizenship Behavior at Company
Authors: Susetyo Izzuel Harits , Sumartik
Published: January 2023

The purpose of the study was to analyze the influence of organizational culture . competence and employe welfare on organizational citizenship behavior (OCB) partially or simultaneosly at PT. Ekadharma international Tbk. in this study the researrcher used Quantitative research. The data in this study used tabulated data from respondents trough both observation and the questionnaire results. The sampling technique was purposive sampling. The sample used in this study were sixty employees at PT. Ekadharma Internasional Tbk. The analysis used multiple linear regression analysis, t test, F test and classical assumption test using SPSS version 25 software. The results of thisstudy indicated that : (1) Organizational Culture, Competence and welfare partially affected organizational citizenship behavior (OCB), (2) Organizational Culture, Competence, and Welfare simultaneously affected organizational citizenship behavior (OCB). based on the finding results, the researcher concluded that competencevariable had the most significant effect on Organizational Citizenship Behavior (OCB) at PT. Ekadharma Internasional Tbk.
The Effect of Organizational Commitment and Physical Work Environment on Turnover Intention with Job Satisfaction as an Intervening Variable at Company
Authors: Solikhah Safa’atus , Andriani Dewi
Published: January 2023

This study aims to examine the Effect of Organizational Commitment and physical Work Environment on Turnover Intention With Job Satisfaction As an Intervening Variable. This study uses a quantitative approach with a survey method. The sampling technique used a saturated sample, that is, the total population was Sampled. So the sample used in this study amounted to 70 employees who work at PT. Setia Kawan Grup in Mojosari. The data analysis technique used Partial Least Square (PLS) with SmartPLS software. The results of study found that there was an influence between Organizational Commitment on Job Satisfaction at PT. Setia Kawan Grup, there is no effect of Organizational Commitment on Turnover Intention at PT. Setia Kawan Grup, there is an effect of the Physical Work Environment on Job Satisfaction at PT. Setia Kawan Grup, there is no effect of the Physical Work Environment on Turnover Intention at PT. Setia Kawan Grup, there is no effect of Job Satisfaction in Turnover Intention at PT. Seti Kawan Grup, there is an effect of Organizational Commitment on Turnover Intention with Job Satisfaction as an intervening variable at PT. Setia Kawan Grup, and there is no influence of the Physical Work Environment on Turnover Intention with Job Satisfaction as an intervening variable at PT. Setia Kawan Grup.
The Effect of Job Satisfaction, Organizational Culture, and Perceived Organizational Support on Organizational Citizenship Behavior on Employee in Company
Authors: Aureliyah Putri Ladynah Zarrah , Kusuma Kumara Adji
Published: January 2023

This study aims to determine the effect of job satisfaction, organizational culture and perceptions of organizational support on organizational citizenship behavior in employees of PT. EMKL Transindra Perkasa Surabaya. This research is a quantitative research type. This research used a sample of 60 employees of PT. EMKL Transindra Perkasa Surabaya. This study uses multiple linear analysis as an analytical technique with the help of the SPSS (Statistical Program for Social Science) version 18.0 application. This study uses primary data and secondary data obtained from the company. Questionnaires are used in research as a tool for statistical testing. The results of the study prove that job satisfaction has an effect on OCB, organizational culture has an effect on OCB, perceptions of organizational support have an effect on OCB. And job satisfaction, organizational culture and perceived organizational support simultaneously affect OCB.
Chronic pain patients in the Brazilian private healthcare system: a claim database study with the experts’ perspective
Authors: Henriques Alexandre , Ogata Alberto , Gondo Celso , Kobayashi Ricardo , Oliveira Rogério , Stefani Stephen , Silva Marco Antonio da , Bilevicius Elizabeth
Published: January 2023

Objective: This study aimed to describe the demands and costs from chronic pain patients over the private Brazilian healthcare system. Methods: This was a retrospective claim database study to assess the resource utilization of pain patients in the private setting. We used a four-year follow-up period to assess inpatient, outpatient, and procedures reported. Further, we promoted a forum of discussion with five pain experts and healthcare managers to address the management of chronic pain and assistance models.Results: We identified 79,689 patients with chronic pain. The orthopedist was the main medical specialist consulted with a total number of 38,879 visits performed. The ophthalmologist, cardiologist, gynecologist, and general practitioner were also frequently consulted (rheumatologist was seldom consulted). Among non-medical specialists, the physical therapist was consulted 87,574 times by 12,342 patients (15% of the entire cohort), Among chronic pain patients, 96% performed at least one exam and 86% of the patients presented at least one ER visit during the follow-up period. In 4 years, we estimate that pain patients costed more than 3 billion reais to the private health care system. According to the experts’ opinions, a fragmented healthcare system and the lack of patient centered interdisciplinary approaches contributes to a high ineffective pain management leading to a high use of resources. Conclusion: There is an urgent need to change the chronic pain care model in the Brazilian private setting. Qualification in pain management, a multidisciplinary patient centered care, integrated approaches, pain centers, and patients’ education may help changing this scenario.
Custo de um município do sul do Brasil com medicamentos de uso contínuo dispensados na Atenção Primária à Saúde
Authors: Gewehr Daiana , Colet Christiane , Bandeira Vanessa
Published: January 2023

Objetivo: Avaliar o custo com medicamentos básicos de uso contínuo de usuários da Atenção Primária em Saúde de Santa Rosa-RS. Métodos: Estudo transversal e analítico realizado em um município do noroeste do Rio Grande do Sul. Foram incluídos usuários cadastrados nas 17 unidades de estratégia de saúde da família, das áreas urbana e rural, em uso de no mínimo um medicamento de uso contínuo. A coleta de dados foi realizada pelo acesso ao sistema informatizado de prescrição eletrônica. Resultados: Foram incluídos 642 usuários, com idade média de 60,40 anos, sendo 64,3% mulheres. Identificou-se média de 4,68 ± 2,82 medicamentos/prescrição e 47,4% ± 14,48 dos usuários em uso de cinco ou mais medicamentos. Dos medicamentos em uso, 87,9% pertencem ao componente básico da assistência farmacêutica. O custo anual do município por usuário de medicamento foi em média de R$ 250,60. O sistema cardiovascular foi o grupo anatômico com maior custo total. Verificou-se maior frequência de uso de medicamentos entre os idosos, que consequentemente representam o grupo etário com maior custo de tratamento. Conclusão: Evidenciou-se que a maioria dos medicamentos prescritos atua sobre os sistemas cardiovascular e nervoso, e pertence ao componente básico da assistência farmacêutica. O custo com medicamentos demonstrou investimento do município de valores 25 vezes maiores do que o mínimo estabelecido pela legislação vigente, com vistas a garantia de acesso ao tratamento e manutenção da qualidade de vida da população assistida.