bluuebunny/crossref_metadata_2025 huggingface dataset:
The Implications of Strategic Inventory for Short-Term vs. Long-Term Supply Contracts in Nonexclusive Reselling Environments
Authors: Roy Abhishek , Gilbert Stephen M. , Lai Guoming
Published: June 2022

Problem definition: Although it is well known that a reseller’s ability to hold strategic inventory under a short-term supply contract can potentially benefit both the reseller and a supplier, existing research on strategic inventory focuses almost exclusively on exclusive reselling environments. However, in practice, multiple suppliers often sell to the same nonexclusive reseller, and it is not uncommon for suppliers to ask for future commitments to order quantities from resellers in return for their own commitment to wholesale prices. We investigate how the possibility of strategic inventory influences competing suppliers’ choices between short-term transactional and long-term commitment contracts to a nonexclusive reseller. Methodology/results: Using a game-theoretic model, we consider the interactions between two partially substitutable suppliers and a single, nonexclusive reseller over a two-period horizon in which demand is deterministic. We demonstrate that in nonexclusive reselling environments, where more than one supplier sells its product through the same reseller, the use of strategic inventory under short-term contracts intensifies the price competition between suppliers. We show how this effect can be mitigated when one or both suppliers offer a long-term contract. Moreover, we show that long-term contracts can arise as an equilibrium outcome, particularly when products are more substitutable or holding costs are large. Managerial implications: By considering the interactions between two partially substitutable suppliers and a nonexclusive reseller in a multiperiod setting, we contribute to the literature on strategic contracting and long versus short-term contracts. Our research provides managers with a new explanation, beyond the need to encourage idiosyncratic investments or eliminate the possibility of hold-up, for why long-term contracts may benefit suppliers in practice, who face competition while selling through a nonexclusive reseller.
Çocuk Acil Kliniğinde Sodyum ve Potasyum Bozuklukları: Tek Merkez Deneyimi
Authors: KONUKSEVER Dilek , YÜCEL KARAKAYA Sevinç Püren
Published: June 2022

Amaç: Bu çalışmada çocuk acil servis başvurularında sodyum ve potasyum bozuklukları spektrumunun incelenmesi amaçlanmıştır.
Gereç ve Yöntemler: Araştırmamız kesitsel ve tek merkezlidir. 2017-2020 yılları arasında çocuk acil kliniğine herhangi bir nedenle başvurup tetkiklerinde sodyum ve/veya potasyum bozukluğu tespit edilen, 18 yaşından küçük hastalar çalışmaya dahil edildi. Hastaların başvuru tanıları ve elektrolit düzeyleri kaydedildi. Elektrolit bozuklukları hafif, orta ve şiddetli olarak gruplandırıldı.
Bulgular: Çalışmaya toplam 757 hasta dahil edildi. Bunların 358 (%47.3)’i kız ve 399 (%52.7)’u erkekti. Katılımcıların 649 (85.8%)’nda tekli elektrolit bozukluğu saptanırken 108 (%14.2)’nde mikst tipte elektrolit bozukluğu saptandı. Hastalarda en sık rastlanan elektrolit bozukluğu hiponatremiydi (%56). Bunu sırasıyla hiperkalemi (%27.5), hipokalemi (%19.9) ve hipernatremi (%10.8) izledi. Akut gastroenterit, hem tek hem de mikst elektrolit bozukluğu gruplarında en sık altta yatan hastalıktı.
Sonuç: Çalışmamız, çocuk acil servislerinde en sık elektrolit bozukluklarının gastroenteritli hastalarda meydana geldiğini saptamıştır. Bu bozukluklar genellikle hafif şiddetteydi. Hafif elektrolit bozuklukları subklinik olabilir, bu nedenle pediatrik acil serviste rutin elektrolit ölçümü erken tanı için önemlidir.
The optimal cutoff score of the 2-min step test and its association with physical fitness in type 2 diabetes mellitus
Authors: Srithawong Arunrat , Poncumhak Puttipong , Manoy Pacharee , Kumfu Sirintip , Promsrisuk Tichanon , Prasertsri Piyapong , Boonla Orachorn
Published: June 2022

This study was carried out to evaluate sensitivity, specificity, and test cutoff score to predict cardiorespiratory fitness by using the 2-min step test (2MST) in patients with type 2 diabetes mellites (DM). The associa-tion of the 2MST and physical fitness tests including a 6-min walk test (6MWT), a 5 time sit-to-stand test (FTSST), and leg strength in the form of a leg performance test were also investigated. This study was cross-sectional and conducted in 100 type 2 DM patients. Patients were screened through health questionnaires, medical illness, general char-acteristics, and physical fitness tests; 2MST, 6MWT, FTSST, and leg strength. Blood was collected for assessment of fasting blood sugar and lipid profiles. The number of steps in the 2MST was positively cor-related with the distance of the 6MWT (r=0.6995, p<0.0001) and leg strength (r=0.4292, p<0.0001). 2MST was negatively correlated with time to perform the FTSST (r=-0.405, p<0.0001). Moreover, this study established the optimal cutoff score of the 2MST at ≤61 steps with 92.24% sensitivity, and 81.36% specificity to predict cardiorespiratory fitness in type 2 DM patients. Our findings indicate that the 2MST may be used as a predictor for walking capacity, leg strength, and ability to change position from sitting to standing in type 2 DM. In addition, this result may imply that patients with type 2 DM performing the 2MST at less than 61 steps was significantly associated with decreased cardio-respiratory fitness.
Utilising interpersonal skills to manage challenging client behaviour
Authors: Stansfield Emma
Published: June 2022

Widespread pandemic-related disruption has led to increasingly challenging client interactions. TheBritish Veterinary Association (BVA) found that 57% of veterinary staff surveyed in 2021 reported feeling intimidated by client behaviour during the previous year; a 10% increase from 2019. The psychological impact of consistently difficult or abusive interactions can be significant and contribute to the high incidences of stress, burnout, attrition and potentially suicide increasingly noted in the industry. This understanding further highlights the need to focus on developing individual self-care strategies and leaders offering appropriate support to their team. Historically, veterinary education has overlooked the importance of training in interpersonal skills, such as communication, conflict resolution and emotional intelligence. However, human and veterinary medicine is evolving with increasing recognition of the significance of communication skills training to help prevent and manage of challenging client behaviour. This may help to ensure practitioners are better prepared for the challenges that await them.
Sustainable Recovery? Deciphering Hungary’s Residential Property Market before the Pandemic
Authors: Dötsch Jörg , Ginter Tamás
Published: June 2022

This paper develops some analytical perspectives for a proper assessment of the dynamics observed on the Hungarian residential property market over the last decade. These dynamics are examined in comparison to official policy objectives. On the one hand, sustainable development and social balance were particularly urgent issues after the last financial crisis. On the other, the residential property market was officially instrumentalised to achieve them. We examined real estate market processes using data from the Hungarian Central Statistical Office and found a change in investment motives and in the main groups of actors dominant in the market, and we also examined the role of foreign investment. At the aggregate national level, the past decade looks like a process of recovery. Nonetheless, the factors relevant for the observable dynamics do not seem to correspond to the goals also formulated in the new constitution, but rather document the investment fever of certain groups.
Housing Uncertainty: Socio-economic Inequality and Forex Loans Trajectories in the Bosnian Housing Market
Authors: Lofranco Zaira
Published: June 2022

This article explores the nexus between the financialisation of housing and socio-economic inequality in Bosnia and Herzegovina (BiH). In this context, since the post-war economic reforms, driven by deindustrialisation, the precarisation of labour, and dependent financialisation, housing loans have become a ‘privilege’ for a restricted group of people with high and stable incomes. Instead, the housing aspirations of Bosnians are generally met with the aid of consumer loans and the ostensibly cheaper FX loans that were introduced in the mid-2000s. Drawing on quantitative and qualitative data, this paper highlights the enduring features of the polarised credit market in BiH. It particularly focuses on the period after the 2008 crisis when lending policies were only mildly re-regulated. FX loans never became the object of an ad hoc law to convert them to Bosnian convertible marks. This institutional approach has been unable to challenge the extreme class segmentation of housing finance and is still fostering indebtedness and precarious housing conditions among the lower-income segments of Bosnian society even after the pandemic.
Emotional Lexicon in Down Syndrome
Authors: Declercq Christelle , Pochon Régis
Published: June 2022

We studied comprehension of emotion versus concrete/abstract words in Down syndrome (DS). Study 1 compared 26 participants with DS and 26 typically developing (TD) children matched on verbal ability. Results showed no difference between groups. Study 2 assessed whether chronological age (CA) and (non)verbal abilities predicted developmental trajectories of comprehension in 36 children with DS and 143 TD children. For the latter, these variables predicted comprehension of all three word types. For the former, receptive vocabulary predicted comprehension of all word types, but CA and nonverbal reasoning only predicted comprehension of concrete words. This suggests that people with DS have no specific emotional lexicon deficit. Supporting their general lexical development would help them access abstract and emotional meanings.
Application of ultraviolet–visible spectroscopy coupled with support vector regression for the quantitative detection of thiamethoxam in tea
Authors: Meng Delong , Ciyong Gu , Li Lin , Zhao Zhimin , Zhang Weichun , Du Chaoling
Published: June 2022

A model combining UV–visible (UV-Vis) spectroscopy and support vector regression (SVR) for the quantitative detection of thiamethoxam in tea is proposed. First, each original UV-Vis spectrum in the sample set is decomposed into some intrinsic mode functions (IMFs) and a residual via ensemble empirical mode decomposition. Next, the decomposed IMFs are reconstructed into high-frequency and low-frequency matrices, and the residuals are combined into a trend matrix. Then, the SVR is used to build regression sub-models between each matrix and the content of thiamethoxam in tea. Finally, the combination model is established by a weighted average of the sub-models. The prediction results are compared with SVR and SVR coupled with several preprocessing methods, and the results demonstrate the superiority of the proposed approach in the quantitative detection of thiamethoxam in tea.
Improvement of a capacitive UV-sensor by porous silicon powders embedded in epoxy on porous silicon film
Authors: Lin Jia-Chuan , Lai Yi-Hsin , Lu Shan-Heng , Wu Chien-Hung , Settu Kalpana
Published: June 2022

A high-sensitivity porous silicon (PS) powder-based capacitive UV-sensor is developed on the PS-film structure. To the best of our knowledge, this is the first report on PS powder-based capacitive UV-sensors. An anodization etching approach based on a sawtooth waveform electrolytic voltage is adopted to get sufficient PS-powders. The collected PS-powders are embedded on the PS-film and covered with epoxy to improve the UV sensitivity. The results show that the increase of UV sensitivity on capacitive characteristics is almost linearly related to the PS powder mass embedded inside. The proposed method is suitable for fine-tuning and improving the equivalent permittivity of the capacitive UV-sensor without changing the device geometry design, which can be compatibly applied to Si-VLSI technology.
Inferring the effective reproductive number from deterministic and semi-deterministic compartmental models using incidence and mobility data
Authors: Andrade Jair , Duggan Jim
Published: June 2022

The effective reproduction number (ℜt) is a theoretical indicator of the course of an infectious disease that allows policymakers to evaluate whether current or previous control efforts have been successful or whether additional interventions are necessary. This metric, however, cannot be directly observed and must be inferred from available data. One approach to obtaining such estimates is fitting compartmental models to incidence data. We can envision these dynamic models as the ensemble of structures that describe the disease’s natural history and individuals’ behavioural patterns. In the context of the response to the COVID-19 pandemic, the assumption of a constant transmission rate is rendered unrealistic, and it is critical to identify a mathematical formulation that accounts for changes in contact patterns. In this work, we leverage existing approaches to propose three complementary formulations that yield similar estimates for ℜt based on data from Ireland’s first COVID-19 wave. We describe these Data Generating Processes (DGP) in terms of State-Space models. Two (DGP1 and DGP2) correspond to stochastic process models whose transmission rate is modelled as Brownian motion processes (Geometric and Cox-Ingersoll-Ross). These DGPs share a measurement model that accounts for incidence and transmission rates, where mobility data is assumed as a proxy of the transmission rate. We perform inference on these structures using Iterated Filtering and the Particle Filter. The final DGP (DGP3) is built from a pool of deterministic models that describe the transmission rate as information delays. We calibrate this pool of models to incidence reports using Hamiltonian Monte Carlo. By following this complementary approach, we assess the tradeoffs associated with each formulation and reflect on the benefits/risks of incorporating proxy data into the inference process. We anticipate this work will help evaluate the implications of choosing a particular formulation for the dynamics and observation of the time-varying transmission rate.
Mathematical modeling of the microtubule detyrosination/tyrosination cycle for cell-based drug screening design
Authors: Grignard Jeremy , Lamamy Véronique , Vermersch Eva , Delagrange Philippe , Stephan Jean-Philippe , Dorval Thierry , Fages François
Published: June 2022

Microtubules and their post-translational modifications are involved in major cellular processes. In severe diseases such as neurodegenerative disorders, tyrosinated tubulin and tyrosinated microtubules are in lower concentration. We present here a mechanistic mathematical model of the microtubule tyrosination cycle combining computational modeling and high-content image analyses to understand the key kinetic parameters governing the tyrosination status in different cellular models. That mathematical model is parameterized, firstly, for neuronal cells using kinetic values taken from the literature, and, secondly, for proliferative cells, by a change of two parameter values obtained, and shown minimal, by a continuous optimization procedure based on temporal logic constraints to formalize experimental high-content imaging data. In both cases, the mathematical models explain the inability to increase the tyrosination status by activating the Tubulin Tyrosine Ligase enzyme. The tyrosinated tubulin is indeed the product of a chain of two reactions in the cycle: the detyrosinated microtubule depolymerization followed by its tyrosination. The tyrosination status at equilibrium is thus limited by both reaction rates and activating the tyrosination reaction alone is not effective. Our computational model also predicts the effect of inhibiting the Tubulin Carboxy Peptidase enzyme which we have experimentally validated in MEF cellular model. Furthermore, the model predicts that the activation of two particular kinetic parameters, the tyrosination and detyrosinated microtubule depolymerization rate constants, in synergy, should suffice to enable an increase of the tyrosination status in living cells.
COVID-19 vaccine acceptance and hesitancy in N’Djamena, Chad: A cross-sectional study of patients, community members, and healthcare workers
Authors: Rice Dylan R. , Balamo Anatole , Thierry Allah-Rabaye , Gueral Aremadji , Fidele Djerakoula , Mateen Farrah J. , Sakadi Foksouna
Published: June 2022

As of March 2022, the COVID-19 vaccination rate in Chad approximated 1%. There are no published reports of COVID-19 vaccine hesitancy or beliefs in Chad. We aimed to study COVID-19 vaccine acceptance and hesitancy among community members, patients, and health care workers in urban Chad. We recruited a prospective convenience sample of adult patients, community members, and healthcare workers from N’Djamena, Chad between August–October 2021. Participants completed a 15-minute, 25-question survey instrument exploring demographic, social, and clinical variables related to COVID-19 and an adapted WHO SAGE Vaccine Hesitancy Survey. Primary outcomes were vaccine acceptance and vaccine hesitancy. Regression models were fit to assess associations between Vaccine Hesitancy Scale (VHS) scores, ranging from 10 (least hesitant) to 50 (most hesitant) points, and pre-selected variables of interest. An inductive thematic analysis was used to analyze the qualitative vaccine hesitancy responses. Of 508 participants (32% female; mean age 32 years), 162 were patients, 153 were community members, and 193 were healthcare workers. COVID-19 vaccine acceptance was significantly higher among patients (67%) than community members (44%) or healthcare workers (47%), p < .001. The average VHS score was 29 points (patients = 27.0, community members = 28.9, healthcare workers = 29.4), and more than one-third of participants were classified as highly vaccine hesitant (score >30 points). Knowing someone who died from COVID-19, believing local healthcare workers support vaccination, trusting the government, having a higher socioeconomic status (i.e. having electricity), and reporting medical comorbidities were each associated with less vaccine hesitancy (all p < .05). The vaccine concerns most frequently endorsed were: vaccine side effects (48%), efficacy (38%), safety (34%), concerns about the pharmaceutical industry (27%), and lack of government trust (21%). Four main themes arose from qualitative vaccine hesitancy responses (n = 116): education, trust, clinical concerns, and misinformation and false beliefs. Overall, COVID-19 vaccine acceptance was low, including among health care workers, and reasons for vaccine hesitancy were broad. We detail the most commonly reported concerns of urban Chadians for receiving the COVID-19 vaccine; we also identify subgroups most likely to endorse vaccine hesitancy. These analyses may inform future vaccination outreach campaigns in N’Djamena.
Zika virus infection drives epigenetic modulation of immunity by the histone acetyltransferase CBP of Aedes aegypti
Authors: Amarante Anderson de Mendonça , da Silva Isabel Caetano de Abreu , Carneiro Vitor Coutinho , Vicentino Amanda Roberta Revoredo , Pinto Marcia de Amorim , Higa Luiza Mendonça , Moharana Kanhu Charan , Talyuli Octavio A. C. , Venancio Thiago Motta , de Oliveira Pedro Lagerblad , Fantappié Marcelo Rosado
Published: June 2022

Epigenetic mechanisms are responsible for a wide range of biological phenomena in insects, controlling embryonic development, growth, aging and nutrition. Despite this, the role of epigenetics in shaping insect-pathogen interactions has received little attention. Gene expression in eukaryotes is regulated by histone acetylation/deacetylation, an epigenetic process mediated by histone acetyltransferases (HATs) and histone deacetylases (HDACs). In this study, we explored the role of the Aedes aegypti histone acetyltransferase CBP (AaCBP) after infection with Zika virus (ZIKV), focusing on the two main immune tissues, the midgut and fat body. We showed that the expression and activity of AaCBP could be positively modulated by blood meal and ZIKV infection. Nevertheless, Zika-infected mosquitoes that were silenced for AaCBP revealed a significant reduction in the acetylation of H3K27 (CBP target marker), followed by downmodulation of the expression of immune genes, higher titers of ZIKV and lower survival rates. Importantly, in Zika-infected mosquitoes that were treated with sodium butyrate, a histone deacetylase inhibitor, their capacity to fight virus infection was rescued. Our data point to a direct correlation among histone hyperacetylation by AaCBP, upregulation of antimicrobial peptide genes and increased survival of Zika-infected-A. aegypti.
Synergistic effect of probiotic, chicory root powder and coriander seed powder on growth performance, antioxidant activity and gut health of broiler chickens
Authors: Gurram Srinivas , Chinni Preetam V. , Vijaya Lakshmi K. , Raju M. V. L. N. , Venkateswarlu M. , Bora Swathi
Published: June 2022

Gut health plays an important role on production and performance of broilers. This trial was undertaken with an aim to evaluate the synergistic effect of probiotic, chicory root powder and coriander seed powder on the performance and gut health of broiler chicken. For this purpose, a total of 240 day-old broiler chicks were randomly allotted to six dietary treatments with 8 replicates of 5 birds in each. Treatment groups included T1 as control i.e., basal diet (BD) without any growth promoter and T2—BD + antibiotic (BMD 0.05%). In the remaining experimental diets, T3—probiotic (@ 0.01%) + chicory root powder (@ 1.0%), T4—probiotic (@ 0.01%) + coriander seed powder (@ 1.5%), T5—chicory root powder (@ 1.0%) + coriander seed powder (@ 1.5%) and T6—probiotic (@ 0.01%) + chicory root powder (@ 1.0%) + coriander seed powder (@ 1.5%). The results indicated that supplementation of probiotic + chicory (T3), probiotic + coriander (T4), chicory + coriander (T5) and probiotic + chicory + coriander (T6) in combination resulted in significantly (P<0.05) higher weight gain and better FCR compared to control and antibiotic groups at 42 d of age. Supplementation of different dietary groups did not show any significant (P>0.05) effect on feed intake of broilers. Supplementation of all the test diets (T3 to T6) significantly (P<0.05) increased the glutathione peroxidase (GSHPx), glutathione reductase (GSHRx) and superoxide dismutase (SOD) enzyme activity when compared to control and antibiotic groups at 42 d of age. Supplementation of all the test diets (T3 to T6) significantly (P<0.05) lowered the pH in the gut, increased Lactobacillus counts, and reduced E. coli and Salmonella counts in the ileum compared to control and antibiotic groups. Supplementation of all the test diets (T3 to T6) significantly (P<0.05) increased the villus height (VH), crypt depth (CD), VH:CD ratio and villus width (VW) in the duodenum and only VH and CD in the ileum compared to control and antibiotic groups. Significantly (P<0.05) higher jejunal VH and VW and increased the goblet cell number in duodenum, jejunum and ileum was recorded in all test diets (T3 to T6) compared to control and antibiotic groups. Therefore, combinations of probiotic (0.01%), chicory root powder (1.0%) and coriander seed powder (1.5%) can be used as feed additive for improving performance and gut health of broiler chicken.
Genome sequence diversity of SARS-CoV-2 obtained from clinical samples in Uzbekistan
Authors: Abdullaev Alisher , Abdurakhimov Abrorjon , Mirakbarova Zebinisa , Ibragimova Shakhnoza , Tsoy Vladimir , Nuriddinov Sharofiddin , Dalimova Dilbar , Turdikulova Shahlo , Abdurakhmonov Ibrokhim
Published: June 2022

Tracking temporal and spatial genomic changes and evolution of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are among the most urgent research topics worldwide, which help to elucidate the coronavirus disease 2019 (COVID-19) pathogenesis and the effect of deleterious variants. Our current study concentrates genetic diversity of SARS-CoV-2 variants in Uzbekistan and their associations with COVID-19 severity. Thirty-nine whole genome sequences (WGS) of SARS-CoV-2 isolated from PCR-positive patients from Tashkent, Uzbekistan for the period of July-August 2021, were generated and further subjected to further genomic analysis. Genome-wide annotations of clinical isolates from our study have revealed a total of 223 nucleotide-level variations including SNPs and 34 deletions at different positions throughout the entire genome of SARS-CoV-2. These changes included two novel mutations at the Nonstructural protein (Nsp) 13: A85P and Nsp12: Y479N, which were unreported previously. There were two groups of co-occurred substitution patterns: the missense mutations in the Spike (S): D614G, Open Reading Frame (ORF) 1b: P314L, Nsp3: F924, 5`UTR:C241T; Nsp3:P2046L and Nsp3:P2287S, and the synonymous mutations in the Nsp4:D2907 (C8986T), Nsp6:T3646A and Nsp14:A1918V regions, respectively. The “Nextstrain” clustered the largest number of SARS-CoV-2 strains into the Delta clade (n = 32; 82%), followed by two Alpha-originated (n = 4; 10,3%) and 20A (n = 3; 7,7%) clades. Geographically the Delta clade sample sequences were grouped into several clusters with the SARS-CoV genotypes from Russia, Denmark, USA, Egypt and Bangladesh. Phylogenetically, the Delta isolates in our study belong to the two main subclades 21A (56%) and 21J (44%). We found that females were more affected by 21A, whereas males by 21J variant (χ2 = 4.57; p ≤ 0.05, n = 32). The amino acid substitution ORF7a:P45L in the Delta isolates found to be significantly associated with disease severity. In conclusion, this study evidenced that Identified novel substitutions Nsp13: A85P and Nsp12: Y479N, have a destabilizing effect, while missense substitution ORF7a: P45L significantly associated with disease severity.
Nitric oxide versus epoprostenol for refractory hypoxemia in Covid-19
Authors: Poonam Pai B. H. , Koscik Rebecca , Nguyen Trong , Rikhi Shefali , Lin Hung-Mo
Published: June 2022

Objective

To compare the efficacy and outcomes with inhaled nitric oxide (iNO) and inhaled epoprostenol (iEPO) in patients with refractory hypoxemia due to COVID-19.

Design

Retrospective Cohort Study.

Setting

Single health system multicenter academic teaching hospitals.

Patients OR subjects

Age group of 18–80 years admitted to the medical ICU.

Interventions

Mechanically ventilated patients with COVID-19 infection, who received either iNO or iEPO between March 1st, 2020, and June 30th, 2020.

Measurements and main results

The primary outcome was the change in the PaO2/FiO2 (P/F) ratio 1 hour after initiation of pulmonary vasodilator therapy. Secondary outcomes include P/F ratios on days 1–3 after initiation, positive response in P/F ratio (increase of at least 20% in PaO2), total days of treatment, rebound hypoxemia (if there was a drop in oxygen saturation after treatment was stopped), ventilator free days (if any patient was extubated), days in ICU, days to extubation, days to tracheostomy, mortality days after intubation, 30-day survival and mortality. 183 patients were excluded, as they received both iNO and iEPO. Of the remaining 103 patients, 62 received iEPO and 41 received iNO. The severity of ARDS was similar in both groups. Change in P/F ratio at one hour was 116 (70.3) with iNO and 107 (57.6) with iEPO (Mean/SD). Twenty-two (53.7%) patients in the iNO group and 25 (40.3%) in the iEPO group were responders to pulmonary vasodilators n(%)(p = 0.152) (more than 20% increase in partial pressure of oxygen, Pao2), and 18 (43.9%) and 31 (50%) patients in the iNO and iEPO group (p = 0.685), respectively, had rebound hypoxemia. Only 7 patients in the cohort achieved ventilator free days (3 in the iEPO group and 4 in iNO group).

Conclusions

We found no significant difference between iNO and iEPO in terms of change in P/F ratio, duration of mechanical ventilation, ICU, in-hospital mortality in this cohort of mechanically ventilated patients with COVID-19. Larger, prospective studies are necessary to validate these results.
Fervor Forever
Authors: Brossard Nicole , Davis Christine
Published: June 2022

A conversation Nicole Brossard and artist Christine Davis about their collaboration Typhon Dru (1990), and Brossard’s relationship to archives (her own and historical) as well as queerness, desire, and the theme of devotion.
René Highway: David Earle with Jonathan Osborn
Authors: Osborn Jonathan
Published: June 2022

A conversation with David Earle about his friendship and collaboration with dancer René Highway, spending particular attention to his collection of personal photographs and how memory/legacy functions in a dance context.
Remembering Ching Ho Cheng
Authors: Wu Simon
Published: June 2022

An interview with Sybao Cheng-Wilson, the sister and executor of Ching Ho Cheng’s estate, with a focus on his life and art and the decisions made after his death regarding his legacy.
Alexander Wilson: Queer Parrhesiast
Authors: Maynard Steven
Published: June 2022

Drawing on and contextualizing the papers of Alexander Wilson (1953-1993), a Toronto-based writer, activist, and horticulturalist, this article explores the reciprocal relationship between Wilson’s intellectual and political work. It focuses on Wilson’s involvement with The Body Politic during the late 1970s and early 1980s, and highlights Wilson’s role in interviewing Michel Foucault in Toronto in 1982. Encompassing feminism, socialism, and environmentalism as part of a critique of narrow notions of ‘gay’ identity and aesthetics, Wilson’s project, it is suggested, prefigured the emergence of queer politics. At the same time, Wilson enacted a queer parrhesia in keeping with Foucault’s Toronto lectures on “speaking the truth about oneself.”
Dad Can Dance
Authors: Ross Jamie
Published: June 2022

An essay about the author’s unexpected discovery about his father’s artistic past, a subsequent search through an archive, and the process of excavating its implications for their relationship and family histories.
Vertical Integration (I visited Vince Aletti)
Authors: Mayer Marc
Published: June 2022

An essay about the interior of Vince Aletti’s home in the context of queer archival practices.
On the Edge of Visibility
Authors: Kearney Simone , Guyer Léonie
Published: June 2022

Poet and artist Simone Kearney interviews artist Léonie Guyer about the history of her work, focusing on the relationships between “shape” and space, form and content, queerness, and the working archives of her own artworks.
GOVERNANCE AND THE NEW BRAZILIAN LAW ON PUBLIC BIDDING AND CONTRACTS: THE POTENTIAL LIMITATION OF COMPETITION UNDER DEBATE
Authors: Prieur Julien , Garbaccio Grace , Marques Bruno
Published: June 2022

Contextualization: The new model of State, which is based more on the stereotype of a constitutional State, imposes an objective of not allowing any constitutional directive to be distorted by the Public Administration. Thus, a recent discussion has been raised among Brazilian academics, following the presentation by the new Law of Acquisition of Public Services and Products; Law 4.253/2020, already approved, which focuses on the requirement of governance by state suppliers, in the same way as is already required of private companies.

Objectives: This article aims to demonstrate how the concept of Public Administration is constantly changing in the face of the various state models adopted. Thus, a requirement such as governance by State suppliers cannot be considered inexcusable, especially in light of the principle of neutrality that should permeate the entire Public Administration.

Methodology: This is a dogmatic study using the dialectical-inductive method of discourse analysis, and content provided by the availability bibliography.

Result: This study discusses how, in the 21st Century any governance requirement that results in a restriction of competitiveness it is considered inconceivable. The assumption of a governance requirement, despite its compatibility with the transparency of the contracts of the century, can never result in a reduction in competitiveness between public providers. This new law should ensure that a certain certiﬁ cate of governance can only be one that is already provided by the Public Administration itself, unless this requirement is imposed after the contractual agreement with the Administration.
LIVRE CONVENCIMENTO JUDICIAL E VERDADE: CRÍTICA HERMENÊUTICA ÀS TEORIAS DE FERRAJOLI, TARUFFO E GUZMÁN
Authors: Streck Lenio , Jung Luã
Published: June 2022

Contextualização: O conceito de livre convencimento judicial é tão institucionalizado no direito brasileiro quanto incompreendido. Nesse sentido, a sua banalização no âmbito judicial e também doutrinário dá azo à discricionariedade.

Objetivo: No presente texto, objetiva-se realizar uma análise acerca dos pressupostos teóricos que sustentam o conceito de livre convencimento judicial, na legislação e no imaginário do direito brasileiro.

Metodologia: O método adotado foi o fenomenológico hermenêutico.

Resultado: Como resultado da pesquisa, conclui-se que a defesa teórica do conceito de livre convencimento se revela insuﬁciente diante dos contra-argumentos apresentados e se sugere um novo modelo de racionalidade judicial pautado pela necessidade epistêmica e política de justiﬁcação.
CONSTITUCIONALIZACIÓN DEL DERECHO EN EL PERÚ
Authors: Grados Guido
Published: June 2022

Contextualización: El fenómeno de la Constitucionalización del Derecho se ha dado en el Perú y en casi todos los estados constitucionales de Derecho. Ha signiﬁ cado el despertar de la Constitución Jurídica, la búsqueda de la eﬁ cacia de los Derechos Fundamentales y el predominio de la Jurisprudencia Constitucional como fuente del Derecho.

Objetivo: De esta forma, el artículo tiene como objetivo analizar el fenómeno de la constitucionalización de los derechos en el Perú.

Metodología: El método adoptado fue el hipotéticodeductivo y la investigación hizo uso de la revisión bibliográﬁca, analizando la evolución doctrinal, así como el posicionamiento de la Corte Constitucional en el Perú.

Resultado: Se concluyó que la Constitución dejó de tener un papel enunciativo y declarativo para ser la medida de toda la juridicidad. Con una diferencia no menor. Mientras la ley es una norma, casi siempre, completa, precisa y concreta, ahora su lugar ha sido ocupado por el texto constitucional que por naturaleza es incompleto, impreciso y general. Resultado, existe la necesidad de que el texto constitucional sea desarrollado, desglosado y adecuado a las nuevas exigencias.
An exploration of interventions for healing intergeneration trauma to develop successful healing programs for Aboriginal Australians: A literature review
Authors:   Twofold Aboriginal Corporation, Simpson Alison , Abur William ,   Deakin University, Charles James ,   Deakin University
Published: June 2022

Introduction Health outcomes and life expectancy of Indigenous people throughout the world are far poorer than non-Indigenous populations. Emerging evidence from research shows that many social issues which impact on Indigenous peoples globally is linked to trauma over generations. This review explores literature about Indigenous people from around the world to seek interventions which have been successful in healing intergenerational trauma. Method To identify interventions that have been successful in healing intergenerational trauma amongst Indigenous populations globally, a systematic search strategy was conducted using keywords and synonyms related to the topic. Peer reviewed academic literature was sourced from four different databases i.e. Ebscohost, PubMed, CINAHL and Medline. Results There were 89 citations, 55 were identified as relevant, after duplicate copies were removed. Of these 55 papers, 23 met inclusion/exclusion criteria. Two additional papers from a reference lists were included and a total of 25 papers were analysed. A comprehensive critical appraisal of the literature was undertaken using three different appraisal tools. This review found that interventions which were successful in healing intergenerational trauma amongst Indigenous populations incorporated traditional cultural practices within their healing method(s). Discussion There was strong evidence that strengthening and reclaiming cultural identity enhances mental health disorders commonly experienced throughout Indigenous populations. Often non-Indigenous clinicians, although well intentioned, fail to address the needs of Indigenous people because they lack the understanding and awareness of Indigenous people’s culture. This review highlights benefits of blending Indigenous and Western approaches into healing intergenerational trauma and the concept of ‘Two-Eyed Seeing’. This concept acknowledges that each of our worlds has its strengths and if we respectfully and methodically accept these strengths, they can work together and effectively to bring about healing. Conclusion Healing from intergenerational trauma is not a straightforward process. Incorporating traditional healing methods assists in the development of cultural identity, which was found to be extremely important in the healing process. To address trauma effectively, clinicians need to acknowledge the historical impact from public policies by having a real understanding of our history.
Aboriginal Health Consumers Experiences of an Aboriginal Health Curriculum Framework
Authors:   Monash University, Atkinson Petah , Baird Marilyn ,   Monash University, Adams Karen ,   Monash University
Published: June 2022

Introduction In settler colonised countries medical education is situated in colonist informed health systems. This form of colonisation is characterised by overt racism and contributes to the significant health inequities experienced by Indigenous peoples. Not surprisingly, medical accreditation bodies in these countries have mandated the curriculum include content relating to Indigenous peoples. However, what is absent is the Indigenous health consumer worldview of health care and their nuanced lived experience of the delivery of medical care. Methods Yarning methods, integral to Aboriginal peoples’ ways of understanding and learning, were utilised. A Yarning guide was constructed with Social Yarn and Research Topic Yarn questions to understand Aboriginal health consumer experiences of the five learning domains within the Aboriginal and Torres Strait Islander Health Curriculum Framework. Data were analysed using Framework Analysis. Results Seventeen Aboriginal adults from urban and rural areas participated in the Yarns during 2018 and 2019. Coding and mapping data identified medical practitioner enacting practices that either perpetuated racism and the settler colonial ideology or facilitated anti-racist health care. Unwanted care included three racism themes described as the practitioner perpetuating and being unresponsive to racism; assimilation and an inability to consider impacts of settler colonialism. Desired care included four anti-racist themes expressed as responsiveness to racism and settler colonialism; advocating within the settler colonial health system; engaging with diversity of Aboriginal ways of knowing, being and doing and lifelong learning and reflection. Conclusion Medical practitioners are promoting ill health through racist practices with Aboriginal health consumers. Aboriginal people’s experiences of racism via continued settler colonial processes and anti-racism in the Australian health system, are critical to meaningful curricula. However, there is a risk for tokenism if the academy continues its coloniality by privileging the biomedical model of illness and health over other models of health.
Protocols for an Aboriginal-led, Multi-methods Study of the Role of Aboriginal and Torres Strait Islander Health Workers, Practitioners and Liaison Officers in Quality Acute Health Care
Authors:   Flinders University, Wilson Annabelle , Mackean Tamara ,   Flinders University, Withall Liz ,   Flinders University, Willis Eileen ,   Flinders University, Pearson Odette ,   South Australian Health and Medical Research Institute, Hayes Colleen ,   Flinders University, O'Donnell Kim ,   Flinders University, Kelly Janet ,   University of Adelaide, Taylor Kerry ,   Flinders University, Dwyer Judith ,   Flinders University, Bourke Elizabeth ,   University of New South Wales, Hunter Kate ,   University of New South Wales, Murakami-Gold Lorna ,   Flinders University, Ivers Rebecca ,   University of New South Wales, Baum Fran ,   Flinders University
Published: June 2022

Objectives Aboriginal and Torres Strait Islander Health Workers/Practitioners and Liaison Officers play an important, often critical role providing advocacy and cultural and emotional support for Aboriginal and Torres Strait Islander patients. The main goals of this research are to explore i) how Aboriginal and Torres Strait Islander Health Workers/Practitioners and Liaison Officers are integrated in the routine delivery of care for Aboriginal and Torres Strait Islander peoples in hospital, and ii) how the role of Aboriginal and Torres Strait Islander Health Workers/Practitioners and Liaison Officers facilitates quality health outcomes. Methods This study is being conducted in three different hospitals using a multi-method approach including: yarning and Dadirri, patient journey mapping, survey and semi-structured interviews. Ethics approval has been provided from four ethics committees covering the three project sites in Australia (Adelaide, South Australia; Sydney, New South Wales and Alice Springs, Northern Territory). Significance This study uses innovative methodology founded on the privileging of Aboriginal and Torres Strait Islander knowledges to collect Aboriginal and Torres Strait Islander perspectives and understand patient journeys within acute health care systems. This project is led by Aboriginal and Torres Strait Islander researchers and guided by the Project Steering Committee comprised of stakeholders. Implications There is limited research that explores quality acute care processes and the integration of Aboriginal and Torres Strait Islander Health Workers/Practitioners work within health care teams. This research will make a valuable contribution to understanding how hospital services can achieve quality acute health care experiences for Aboriginal and Torres Strait Islander People.
Examining the Associations Between Experiences of Perceived Racism and Drug and Alcohol Use in Aboriginal Australians
Authors:   Monash University, Gentile Victoria , Carter Adrian ,   Monash University, Jobson Laura ,   Monash University
Published: June 2022

Objective This study aimed to explore the relationships between experiences of perceived racism, mental health and drug and alcohol use among Aboriginal Australians. Method Sixty-two Aboriginal Australians, ranging in age from 19-64 years (Mage = 33.71, SD = 12.47) and residing in Victoria completed an online questionnaire containing measures of perceived racism, alcohol use, substance use and mental health. Results First, 66% of the sample reported experiencing interpersonal racism, with the highest proportion of reported experiences occurring in health settings, educational/academic settings and by staff of government agencies. Second, perceived racism was significantly associated with poorer mental health and well-being. Finally, while perceived racism was not significantly associated with substance use, there was an indirect pathway from perceived racism to substance use through mental health concerns. Conclusions The current research indicates that racism is still frequently experienced by Aboriginal Australians and is directly associated with poorer mental health, and indirectly with substance use through poorer mental health. The findings demonstrate a clear need for further research in this area.
Analisis Karakter Tanggung Jawab Ditinjau dari Kemampuan Awal Pemecahan Masalah melalui Problem Based Learning
Authors: Kuncoro Krida Singgih , Istiqomah  , Hakim Luki Luqmanul , Widodo Sri Adi
Published: June 2022

Karakter tanggung jawab merupakan salah satu karakter yang harus dimiliki oleh mahasiswa sebelum terjun ke dunia kerja. Penelitian ini bertujuan untuk mengetahui karakter tanggung jawab ditinjau dari kemampuan awal pemecahan masalah melalui model pembelajaran Problem Based Learning. Metode penelitian yang digunakan adalah metode kombinasi (mixed method) dengan model sequential explanatory yakni penggabungan metode penelitian kuantitatif dan metode kualitatif secara berurutan. Analisis data kuantitatif diarahkan untuk menganalisis kemampuan awal pemecahan masalah mahasiswa dan analisis data kualitatif diarahkan untuk mengetahui karakter tanggung jawab berdasarkan kemampuan awal pemecahan masalah. Subjek penelitian ini adalah mahasiswa pendidikan matematika Universitas Sarjanawiyata Tamansiswa semester 1 sejumlah 37 mahasiswa. Hasil penelitian menunjukkan bahwa terdapat peningkatan pembentukan karakter tanggung jawab mahasiswa selama pembelajaran Problem Based Learning jika ditinjau dari kemampuan awal pemecahan masalah.
Penyelesaian Soal Geometri Analitik Mahasiswa Ditinjau dari Karakteristik Cara Berpikir
Authors: Azka Raekha , Nurvitasari Ika , Permatasari Dian
Published: June 2022

Geometri analitik merupakan mata kuliah wajib yang harus ditempuh mahasiswa Pendidikan Matematika. Penyelesaian persoalan geometri menjadi salah satu hal yang harus dipunyai oleh mahasiswa. Karakteristik cara berpikir mahasiswa perlu diketahui agar dapat melihat perbedaan dalam penyelesaian soal maupun dalam penerimaan konsep-konsep. Penelitian ini mempunyai tujuan melihat lebih jauh karakter cara berpikir mahasiswa dalam penyelesaian soal geometri. Penelitian ini merupakan penelitian analisis deskriptif di mana jumlah mahasiswa yang diteliti berjumlah 31 orang dengan mahasiswa wawancara dipilih 8 orang. Dilakukan 2 buah tes yaitu tes mengenai persoalan geometri analitik dan tes untuk melihat tipe cara berpikir mahasiswa. Dari hasil data didapat tipe berpikir mahasiswa ada 4  yaitu Sekuensial kongkret, Sekuensial Abstrak, Acak kongkret, Acak abstrak serta 2 tipe campuran yaitu Acak kongkret Acak abstrak dan Acak kongkret, Acak abstrak Acak abstrak. Masing - masing tipe mempunyai cara penyelesaian berbeda dan pemahaman berbeda mengenai persoalan geometri analitik ditinjau dari proses pengerjaannya, teknik dan ketelitian.
Students' Mathematical Communication: COVID-19 Problem-solving Experience Among High Achievers
Authors: Purbaningrum Mayang , Lus Windyana Palupi Evangelista
Published: June 2022

Mathematical communication skills are the ability to convey mathematical ideas, strategies, and solutions to solve mathematical problems, both written and verbal. The community must express ideas to solve mathematical problems in daily life or tell essential information, such as the news related to COVID-19. . The selection of subjects in this study used purposive sampling with the subjects of 3 high achievement students in ten grade. Subjects are selected based on the average daily test scores. Data collection was conducted by mathematical communication test using PISA liked problem uncertainty and data context about hand sanitizer and interview. The triangulation technique analyzed the result of test and interview data. The results showed that students with high achievement have high mathematical communication skills. Students with high achievement can present mathematical ideas orally and in writing, interpret and evaluate the strategy, the results obtained, and use terms, mathematical notation, and math symbols. Thus, high achievement students can communicate and solve problems in the context of COVID-19. This research provides new information about the mathematical communication of students with high mathematical abilities, so it can be one of the teacher's guidelines for determining appropriate learning to improve students' mathematical communication.