bluuebunny/crossref_metadata_2025 huggingface dataset:
Late-stage functionalization of glucosides and aminoglycosides to combat resistant pathogens
Authors: guo tianyun , yan xiaoxiao , cao haonan , lu lei , gao lina , tang shouchu , liu jian , wang xiaolei
Published: June 2022

The rapid emergence of resistant bacteria and the scarcity of antibiotic pipeline has been a persistent threat to the global health. To expand the antibiotic pipeline, we have focused our strategy by revitalizing the current antibiotic via novel site-specific derivatization. Aminoglycosides (AGs), once considered effective therapeutics for treating clinical infections, are now seeing limited use due to drug-induced toxicity and AG-resistant bacteria. Challenges in synthesis and modifications of AGs impedes their potential for re-gaining efficacy. Here we discuss a photoredox catalyzed late-stage modification of glucosides including AGs. Our chemistry can selectively install an alkyl group at the 3- position of unprotected glucoside with a broad substrate scope and high yields. Among the products, we characterized a series of compounds that can overcome drug resistance caused by APH (3’) and one of them achieved 30-fold potency compared to kanamycin against sensitive strains. The chemistry we describe here opens a new avenue for discovering new AGs antibiotics that overcome drug resistance and may also serve as the basis for understanding their SARs.
Strategies for Transferring Photobiocatalysis to Continuous Flow Exemplified by the Photodecarboxylation of Fatty Acids
Authors: Simić Stefan , Jakštaitė Miglė , Huck Wilhelm T. S. , Winkler Christoph K. , Kroutil Wolfgang
Published: June 2022

The challenges of light-dependent biocatalytic transformations of lipophilic substrates in aqueous media are manifold. For instance, photolability of the catalyst as well as insufficient light penetration into the reaction vessel may be further exacerbated by a heterogeneously dispersed substrate. Light penetration may be addressed by performing the reaction in continuous flow, which allows two modes of applying the catalyst: (i) heterogenously, immobilized on a carrier, which requires light-permeable supports, or (ii) homogenously, dissolved in the reaction mixture. Taking the light-dependent photodecarboxylation of palmitic acid catalyzed by the fatty-acid photodecarboxylase from Chlorella variabilis (CvFAP) as a showcase, strategies for the transfer of a photoenzyme-catalyzed reaction into continuous flow were identified. A range of different supports was evaluated for the immobilization of CvFAP, whereby Eupergit C250 L was the carrier of choice. As the photostability of the catalyst was a limiting factor, a homogeneous system was preferred instead of employing the heterogenized enzyme. This implied that photolabile enzymes may preferably be applied in solution if repair mechanisms cannot be provided. Furthermore, when comparing different wavelengths and light intensities, extinction coefficients may be considered to ensure comparable absorption at each wavelength. Employing homogenous conditions in the CvFAP-catalyzed photodecarboxylation of palmitic acid afforded a space-time yield unsurpassed by any reported batch process (5.7 g/L·h, 26.9 mmol/L·h) for this reaction, demonstrating the advantage of continuous flow in attaining higher productivity of photobiocatalytic processes.
Grapefruit IntegroPectin isolation via spray drying and via freeze drying: a comparison
Authors: Di Prima Giulia , Scurria Antonino , Angellotti Giuseppe , Belfiore Elena , Pagliaro Mario , Meneguzzo Francesco , De Caro Viviana , Ciriminna Rosaria
Published: June 2022

The comparison of grapefruit IntegroPectin powders isolated via spray drying and via freeze drying in terms of phenolic content, quantification of the most representative flavonoids (naringin and hesperidin), radical scavenging activity, total protein content and pH of the aqueous solutions provides relevant information. Except for the protein content, the two drying methods afford largely similar pectins. Optimization of the spray drying parameters allowed to maximize the yield of isolated pectin that nearly approached (>95%) the quantitative yield obtained via freeze drying.
Making Friends Meet: Network Formation with Introductions
Authors: Siedlarek Jan-Peter
Published: June 2022

This paper proposes a parsimonious model of network formation with introductions in the presence of intermediation rents. Introductions allow two nodes to form a new connection on favorable terms with the help of a common neighbor. The decision to form links via introductions is subject to a trade-off between the gains from having a direct connection at lower cost and the potential losses for the introducer from lower intermediation rents. When nodes take advantage of introductions, stable networks tend to exhibit a minimum amount of clustering. At the same time, intermediary nodes have incentives to protect their position, and stable networks can exhibit nodes exploiting structural holes, that is, bridges across otherwise unconnected parts of the network earning intermediation rents.
Upholding Multilateralism: Indonesia’s Foreign Policy in Responding to Covid-19 Pandemic
Authors: Luerdi Luerdi , Setiawan Azhari
Published: June 2022

The 2019 Coronavirus disease or COVID-19 has apparently become a new global challenge. Not only did the pandemic drive all actors to make response, but it also affected the relations among them. That Indonesia raised multilateralism in the unprecedented situation while more unilateral or populist actions taken by a number of states encouraged this research. This paper attempts to explain Indonesia’s foreign policy in upholding multilateralism to respond to the COVID-19. Such response was intended to mitigate the impacts caused by the pandemic. This research applied holistic constructivism in understanding the determinants of Indonesia’s foreign policy by investigating both domestic and international cause. This research utilized the qualitative method with an explanatory analysis. The findings show that such Indonesia’s foreign policy was driven by its identity constructed by both indigenous norm of ‘Gotong Royong’ and global norm of ‘International Health Regulation’. The norm-laden or identity-based foreign policy was leading it to uphold multilateralism which was considered appropriate in order to coordinate, collaborate and cooperate with international communities. In addition, Indonesia maintained its trust on and support to the World Health Organization as the most leading actor in health governance championing fight against the pandemic. This paper argues that the norm factors do matter in Indonesia’s foreign policy in facing uncertainties in the vulnerable and interconnected world. Through the case studied, this paper suggests that looking at the domestic actor as well as the state in international system help provide a better understanding on the state behavior in international relations.
Resolving or Creating Conflicts Examining Role of Political Talk Shows in Pakistan
Authors: Awais Sajida , Ashraf Atif , Shabir Ghulam , Balouch Saba
Published: June 2022

Purpose: This study is “Role of Television Talk Shows in Political Conflict Resolution after General Elections 2013: A Study of Pakistan Tehreek e Insaaf and Pakistan Muslim League –N”. The research has aimed to explore the role of political talk shows in resolving the political conflict between PTI and PML-N, to assess their issues regarding their conflict, to examine the discussion on matters of common interest among them and to compare and analyze the discussion on matters of common interests and disputing issues between PTI and PML-N in television political talk shows.

Design/Methodology/Approach: This research has used quantitative content analysis for collecting data and has concluded that the political talk shows have not been playing a positive role in resolving the political conflict between conflicting parties and moreover the role of political talk shows has been escalating in the process of political conflict resolution between PTI and PML-N. 

Findings:  This study has also concluded that the role of anchor persons has not facilitated the discussion of talk shows towards a need of any possible solution regarding the discussed problem between PTI and PML-N.  

Implications/Originality/Value: It has been concluded that the political talk shows have highlighted the disputing and controversial issues between the conflicting parties instead of discussing the matters of common interests among them. The political talk shows have not encouraged a need of any possible solution regarding the political conflict resolution between PTI and PML-N after general elections 2013.
Karakterisasi dan Uji Efektivitas Sediaan Gel Aloe vera Kombinasi Kitosan sebagai Antibakteri Staphylococcus aureus
Authors: Cahyaningrum Sari Edi , Susanti Perintis Gita
Published: June 2022

Penelitian mengenai pengembangan sintesis sediaan gel Aloe vera kombinasi kitosan sebagai antibakteri Staphylococcus aureus telah dilakukan. Penelitian ini memiliki tujuan untuk mengetahui pengaruh perbandingan komposisi Aloe vera dengan kitosan terhadap karakterisasi dan efektivitas antibakteri Staphylococcus aureus sebagai kandidat obat luka sayat. Sintesis sediaan gel Aloe vera kombinasi kitosan dilakukan dengan cara mencampurkan Aloe vera dan larutan kitosan menggunakan perbandingan berat 2:1; 1:1; dan 1:2 (AvK1, AvK2, dan AvK3), serta penambahan Na-CMC, gliserin, dan propilen glikol, yang mana hasil sediaan gel dinetralkan hingga mencapai pH 6,5–7,0. Hasil sediaan gel dikarakterisasi secara organoleptik, pengukuran viskositas, identifikasi gugus fungsional, serta uji efektivitas antibakteri Staphylococcus aureus dengan metode difusi. Hasil penelitian menunjukkan dari pengamatan organoleptik yaitu warna, aroma, dan tekstur. Karakterisasi pengukuran viskositas terendah dihasilkan oleh gel AvK3 yakni sebesar 13,0412 mPa.s. Hasil identifikasi gugus fungsional dari semua sediaan gel menunjukkan adanya vibrasi ulur O–H dan N–H, vibrasi ulur C=O, dan vibrasi tekuk C–H, serta vibrasi ulur C–O. Serta uji antibakteri Staphylococcus aureus dari sediaan gel Aloe vera kombinasi kitosan dengan berbagai variasi menunjukkan hasil yang efektif yakni yang terkuat ditunjukkan oleh gel AvK1 dengan zona hambat sebesar 26 mm.

 

Kata kunci : kitosan, Aloe vera, antibakteri, Staphylococcus aureus
PENGARUH PEMBERIAN SIRUP UMBI YAKON TERHADAP KADAR KALSIUM TULANG FEMUR TIKUS PUTIH (Rattus Norvegicus)
Authors: Yuanita Leny , K Kelvin Rio
Published: June 2022

Tujuan penelitian untuk mengetahui: 1) pengaruh suplementasi sirup umbi yakon terhadap kadar kalsium tulang tikus 2) korelasi jumlah total asam lemak rantai pendek (ALRP) terhadap kadar kalsium tulang tikus. Hewan coba yang digunakan adalah 36 ekor Rattus norvegicus, terbagi 3 kelompok perlakuan suplemen: 1) perlakuan air, 2) sirup umbi yakon, 3) FOS komersial. Perlakuan selama 48 hari, tulang femur digunakan sebagai sampel yang dianalisis kadar kalsium dengan metode destruksi. Instrumen  yang digunakan adalah HPLC untuk uji kadar ALRP, GC uji kadar FOS, dan AAS uji kadar kalsium.. Analisis data melalui uji Anova satu jalur (α=0,05), Post Hoc LSD, dan korelasi product moment (α=0,05). Hasil analisis menunjukkan 1) Kenaikan hasil rata-rata kadar kalsium dari kelompok K(-) terhadap P1 sebesar 1,211 mg/mL dan uji statistik post hoc antara kelompok K(-) dan P1 (p>0,05) menunjukkan tidak adanya perbedaan secara signifikan suplementasi sirup umbi yakon terhadap kadar kalsium tulang tikus. 2) Analisis korelasi menunjukkan hasil koefisien korelasi sebesar r = 0,394 sehingga terdapat hubungan yang rendah antara jumlah total ALRP dengan kadar kalsium pada tulang femur hewan coba.

Kata kunci: umbi yakon, FOS, kalsium, absorpsi
Artearen historia digital parekiderantz: euskal emakume artistak Wikipedian
Authors: Luengo Aguirre Maite , Arranz Bombín Marina
Published: June 2022

Euskal testuinguru akademikoan humanitate digitalak garatzen ari diren honetan, ikerketa-ildo berriak zabaltzen ari dira. Horietako bat euskarazko Wikipediak ezagutza-alorrekin duen harremana dugu. Artikulu honetan, zehazki, artearen historia osatzean emakume artistak ikusarazteko duen gaitasunaren azterketa burutu dugu. Helburu nagusia izan da autoreen ikusgaitasunerako Wikipediak eskaintzen dituen aukera eta erronken inguruan hausnartzea. Horretarako, lehendabizi artearen historiako kontaketaren oinarriak berrikusi ditugu, irizpide tradizionaletatik abiatu eta gero, berrikuspen feministetan kokatu gara, Wikipediak eskaintzen dituen aukerak behatzeko. Ondoren, Wikipediako euskal artisten sarrerak aztertu ditugu. Alde batetik, artista kopuruen genero-banaketak hartu ditugu kontuan joerak azaleratzeko; bestetik, existitzen diren biografien ezaugarriak aztertu ditugu, idazkera, adinjoera eta irudien presentzian arreta jarriz. Era horretan, euskal emakume artistek Wikipedian duten oraingo egoera argitu eta, etorkizunera begira, ikerketa-ildo hau garatzeko oinarrizko ezagutza eskainiko dugu.
Euskal traol-aktibismo feminista: 2021eko Emakumeen Nazioarteko Egunaren elkarrizketa digitalaren azterketa
Authors: Orbegozo Terradillos Julen , Zarrabeitia Bilbao Enara , Alvarez Meaza Izaskun
Published: June 2022

Ikerketa honek 2021eko martxoaren 8an, Emakumeen Nazioarteko Egunean, Twitterren sortutako elkarrizketa digitala aztertzen du. Helburua da euskal feminismoaren online mobilizazioaren deskribapena egitea, euskarazko traolen monitorizazioaren bitartez. martxoaren 4tik 9ra, 4.444 erabiltzaileren 10.569 txiok osatzen dute lagina eta txioak big data teknikak aplikatuz prozesatu dira, Pajek, Gephi eta Orange Data Mining softwareak erabiliz. Hala, ad-hoc diseinatutako prozesu metodologiko zehatza inplementatzen da. Emaitzek agerian utzi dute ikertutako elkarrizketak sare horizontal eta plurala eraikitzen duela, bi ardatz nagusi oinarri hartuta: ezkerreko ideologia eta abertzaletasuna. Halaber, kasu paradigmatikoa da eztabaida publiko digitaletan eragiteko eragileen estrategiek dituzten ondorioak ikusarazteko.
Muturreko goiztiarren profil neuropsikologikoaren luzetarako azterketa
Authors: Labayru Isusquiza Garazi , Arrizabalaga Ane , Santos Andrea , Aliri Lazcano Jone , Marti Carrera Itxaso , Sistiaga Berrondo Andone
Published: June 2022

Muturreko goiztiarrek neurogarapenari dagokionez duten zaurgarritasunaren inguruan literatura zientifikoa bada ere, gaur egun arte ez da horren deskribapenik egin gure inguru geografikoan. Haurren zailtasun eta beharrak garapeneko aldi bakoitzean aldatzen direla kontuan izanik, lan honen helburua muturreko goiztiarren jarraipen neuropsikologikoa egitea da. Bi urterekin garapen psikomotorra (Bayley- III) eta 6 urterekin adimen-maila (WISC-V) eta domeinu kognitibo zein sintoma sozioemozional desberdinak aztertu dira 23 haurretan. Bi urterekin domeinu zehatz batzuetan zailtasunak aurkeztu badira ere (hitzezko ekoizpenean eta motrizitate sendoan), eskola-adinean adimen-koziente arinki murriztua eta arreta mantenduan, funtzio exekutiboan eta hitzezko ulermenean zailtasunak behatu dira. Aldiz, ez da maila sozioemozionalean zailtasunik topatu. Emaitzek aditzera ematen dute muturreko goiztiarren zaurgarritasuna eta populazio horren jarraipena skolaadineraino egiteko beharra. Era berean, gure lurraldean tresna neuropsikologikoen baliozkotasunaren inguruan egin beharreko lana agerian uzten da.
Penerapan Kode Etik Keinsinyuran untuk Mengatasi Permasalahan Kegiatan Program Pengembangan Produk Unggulan Daerah (PPPUD)
Authors: Kusuma Yudha Adi , Bima Alim Citra Aria
Published: June 2022

Kode etik menjadi panduan dalam melangkah berdasarkan lingkup pekerjaan yang dijalani. Sebagai seorang insinyur profesional mematuhi kode etik adalah hal yang mutlak agar tidak salah sasaran. Persatuan Insinyur Indonesia (PII) telah menetapkan perihal kode etik insinyur melalui “catur karsa sapta dharma insinyur Indonesia”. Kajian klasifikasi masalah kode etik pada Program Pengembangan Produk Unggulan Daerah (PPPUD) dibagi menjadi awal kegiatan, pelaksanaan dan akhir kegiatan. Berdasarakan pengukuran anailisis diskriptif ditemukan 7 permasalahan yang terjadi saat program PPPUD berlangsung. Atas dasar catur karsa sapta dharma insinyur diharapkan memberikan kontribusi terhadap kegiatan PPPUD sebagai program untuk meningkat mutu produk unggulan daerah.
Analisis Risiko K3 pada Area Produksi Shuttlecock menggunakan Metode Hirarc Di UKM Prospek Badminton Shuttlecock
Authors: Khotimah Ika anggraeni Khusnul , Allo Afrilia Linggi
Published: June 2022

UKM prospek badminton shuttlecock merupakan salah satu perusahaan di kota Malang yang memproduksi shuttlecock untuk didistribusikan ke berbagai wilayah jawa, sumatra, sulewesi dan wilayah indonesia timur. Identifikasi permasalahan yang ada di UKM yaitu terkait dengan kesehatan dan keselamatan kerja yang belum ada Standar  Operasi  Prosedur, lingkungan UKM masih belum menerapkan K3, dan mengabaikan bahaya  yang dapat menimbulkan kecelakaan kerja. Penelitian ini bertujuan untuk melakukan identifikasi bahaya dan penilaian risiko kerja yang termasuk dalam kategori risiko extreme di UKM prospek badminton shuttlecock sehingga mampu memberikan rekomendasi dan mitigasi risiko untuk mencegah terjadinya kecelakaan kerja. Metode yang digunakan adalah HIRARC. Adapun tahapan dalam metode tersebut adalah mengidentifikasi bahaya (hazards identification), penilaian risiko (risk assessment) dan pengendalian risiko (risk control). Dari hasil perhitungan Berdasarkan hasil analisis data yang telah dilakukan, maka kesimpulan yang dapat diambil dalam penelitian ini, aktivitas kerja yang memiliki potensi bahaya dan risiko dengan kategori risiko extreme yang akan diberikan usulan pengendalian risikonya yaitu  aktivitas pemasakan bulu, bor gabus, pemasangan bulu, penjahitan, pengeleman, pengetesan, servis, pengemasan.
Efficacy and safety of hyperbaric oxygen treatment to treat COVID-19 pneumonia: a living systematic review update
Authors:   Department of Anesthesiology and Pain Medicine, The Ottawa Hospital, Ottawa, Canada, Boet Sylvain ,   Department of Anesthesiology and Pain Medicine, The Ottawa Hospital, Ottawa, Canada,   Francophone Affairs, Faculty of Medicine, University of Ottawa, Ottawa, Canada, Etherington Cole ,   Clinical Epidemiology Program, The Ottawa Hospital Research Institute, Ottawa, Canada, Ghanmi Nibras ,   Department of Public Health Sciences, Faculty of Health Sciences, Queens University, Ontario, Canada, Ioudovski Paul ,   Department of Public Health Sciences, Faculty of Health Sciences, Queens University, Ontario, Canada, Tricco Andrea C ,   Li Ka Shing Knowledge Institute, St Michael’s Hospital, Unity Health Toronto, Toronto, Ontario, Canada,   Epidemiology Division and Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada,   Queen’s Collaboration for Health Care Quality: A JBI Centre of Excellence, Ontario, Canada, Sikora Lindsey ,   Health Sciences Library, University of Ottawa, Ottawa, Canada, Katznelson Rita ,   Department of Anesthesia and Pain Management, University Health Network, Toronto, Ontario, Canada
Published: June 2022

Introduction: As the COVID-19 pandemic evolves, new effective treatment options are essential for reducing morbidity and mortality as well as the strain placed on the healthcare system. Since publication of our initial review on hyperbaric oxygen treatment (HBOT) for hypoxaemic COVID-19 patients, interest in HBOT for COVID-19 has grown and additional studies have been published. Methods: For this living systematic review update the previously published search strategy (excluding Google Scholar) was adopted with an extension from 01 February 2021 to 01 April 2022. Study inclusion criteria, data extraction, risk of bias estimation and dispute resolution methods were repeated. Results: Two new studies enrolling 127 patients were included in this update, taking the total to eight studies with 224 patients. Both new studies were randomised controlled trials, one at moderate and one at high risk of bias. Across these eight studies, 114 patients were treated with HBOT. All reported improved clinical outcomes without observation of any serious adverse events. Meta-analysis remained unjustified given the high heterogeneity between studies and incomplete reporting. Conclusions: This updated living systematic review provides further evidence on the safety and effectiveness of HBOT to treat acute hypoxaemic COVID-19 patients.
Hyperbaric oxygen treatment in a rare complication of intramuscular injection: four cases of Nicolau syndrome
Authors:   Department of Underwater and Hyperbaric Medicine, Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey, Korpinar Sefika
Published: June 2022

Intramuscular injections are one of the most common clinical procedures. The objectives of this case series are to analyse the role, timing and efficacy of hyperbaric oxygen treatment (HBOT) in the management of Nicolau syndrome (NS), an extremely rare complication of this common intervention. Clinical, demographic, laboratory and microbiological data extraction were performed through retrospective analysis of the medical records of all patients with NS who were referred for HBOT over a 10-year period with wounds, ischaemia, infection or necrosis at the injection site following drug injection; four patients with NS were included. All injections were made via the intramuscular route; three adult cases followed a non-steroidal anti-inflammatory drug, diclofenac sodium and one in a child followed penicillin injection. The time between diagnosis/injection and HBOT ranged from five to 33 days. NS can develop despite all preventive measures based on injection technique guidelines. HBOT appeared beneficial to healing of NS when administered with other therapeutic approaches. Due to the missing pieces of the puzzle in pathogenesis, NS is rarely completely reversible; keeping the awareness high for undesirable complications stands out as the most effective approach.
Муниципальное хозяйство: история и современность
Authors:   НОЧУ   ВО   «Московский   экономический институт», Коробко В.И. , Соклакова И.В. ,   НОЧУ ВО «Московский экономический институт», Останкова Н.В. ,   НОЧУ ВО «Московский экономический институт», Сергеева С.А. ,   МГИМО, Сурат И.Л. ,   НОЧУ  ВО «Московский экономический институт», Трофимовская А.В. ,   Московский городской университет управления Правительства Москвы., Коробко В.И.
Published: June 2022

Представлена история возникновения и формирования муниципального хозяйства в России и за рубежом. Рассмотрено муниципальное хозяйство в современных условиях рынка с позиции комплексного метода исследования исторических, экономических и правовых основ местного самоуправления (в сфере муниципальной недвижимости, жилья, муниципальных земельных облигаций, жилищного коммунального хозяйства).Для научных работников, служащих сферы муниципального управления, преподавателей, аспирантов, студентов магистратуры и бакалавриата.
Análisis de la Educación Inclusiva: Un enfoque desde la realidad institucional en la ciudad de Quito-Ecuador
Authors: Cañar Carolina , Baquero Dayana
Published: June 2022

La Educación Inclusiva permite eliminar las barreras de exclusión social educativa, donde los planteles y sus docentes deben considerar la diversidad presente en la clase, pues existen personas que dependen de una necesidad educativa asociada o no a la discapacidad, de esta manera, es necesario preparar estrategias metodológicas, incentivando el aprendizaje de todos los niños por igual. El propósito del escrito es evidenciar si los centros educativos y sus docentes están preparados para atender a los estudiantes con algún tipo de discapacidad. Por otra parte, los objetivos específicos se basan en indagar la normativa educativa vigente en el país y demostrar la discrepancia que existe entre lo que propone el Estado y lo evidenciado en instituciones fiscales, municipales y particulares de la ciudad de Quito. Método: La muestra estuvo compuesta por 30 docentes y 30 estudiantes de la provincia de Pichincha pertenecientes a instituciones educativas fiscales, municipales y particulares; en donde se registró los datos mediante encuestas. Resultados: se identificó que las instituciones no capacitan al personal docente, asumiendo que 9 de cada 10 escuelas no implementan en sus aulas un equipamiento adecuado y 5 de cada 10 no realizan adaptaciones físicas para atender las NEE de sus estudiantes.
PENGARUH PERENCANAAN PENUGASAN TERHADAP KUALITAS HASIL PEMERIKSAAN DI INSPEKTORAT KABUPATEN BENER MERIAH
Authors: Saroh Umi , Nurafni Nurafni , Muntasir Muntasir
Published: June 2022

Penelitian ini mengaji tentang pengaruh perencanaan penugasan terhadap kualitas hasil pemeriksaan di inspektorat Kabupaten Bener Meriah. Tujuan penelitian adalah adalah untuk mengetahui pengaruh perencanaan penugasan Audit terhadap kualitas hasil pemeriksaan pada Inspektorat Kabupaten Bener Meriah dan bagaimana proses penempatan personil Aparatur Pengawasan Intern Pemerintah di Inspektorat Kabupaten Bener Meriah. Perspektif teori yang digunakan adalah teori manajemen sumber daya manusia dan pengujian secara simultan dan parsial. Penelitian ini menggunakan metode kuantitatif, teknik pengumpulan data dilakukan dengan kuesioner skala linkert kepada 40 responden Aparatur Pengawasan Intern Pemerintah (APIP). Analisis data dilakukan dengan menggunakan SPSS (Statistical Package for Social Science) versi 26. Berdasarkan hasil analisis linier berganda diperoleh bahwa masing-masing variabel bebas mempengaruhi variabel terikat yaitu kualitas hasil pemeriksaan. Nilai koefisien regresi sebesar 0,416 untuk variabel perencanaan penugasan audit. Nilai koefisien regresi ini menunjukkan bahwa perencanaan penugasan audit terhadap kualitas hasil audit tidak sama dengan nilai nol atau i (i = 1, 2, 3) 0. Dengan demikian, dapat dikatakan bahwa penugasan audit perencanaan secara bersama-sama mempengaruhi kualitas hasil audit. Pengujian secara individual (parsial) nilai koefisien regresi perencanaan penugasan audit adalah 0,001, lebih kecil atau di bawah taraf signifikan 0,05 sehingga perencanaan penugasan berpengaruh positif terhadap kualitas hasil audit. Hasil penelitian menunjukkan bahwa Perencanaan penugasan audit secara parsial berpengaruh terhadap terhadap kualitas hasil pemeriksaan.
PENGEMBANGAN LKS (LEMBAR KERJA SISWA) BERBASIS VIRTUAL LAB BERBANTUAN SIMULASI PHET UNTUK MENINGKATKAN KETERAMPILAN BERPIKIR KRITIS SISWA PADA MATERI GETARAN HARMONIK
Authors: Muliani Muliani , Siska Deassy , Hasri Ainul
Published: June 2022

Penelitian ini bertujuan untuk: 1)  mengetahui kelayakan LKS berbasis virtual lab berbantuan simulasi PhET. 2) mengetahui besar peningkatan keterampilan berpikir kritis siswa setelah menggunakan LKS berbasis virtual lab berbantuan simulasi PhET. 3) mengetahui respon siswa terhadap LKS berbasis virtual Lab berbantuan simulasi PhET. Penelitian ini menggunakan  metode Research and Development (R&D). Instrumen pengumpulan data menggunakan LKS, soal  Essay dan angket respon siswa. Berdasarkan hasil penelitian menunjukkan bahwa LKS berbasis virtual lab berbantuan  simulasi PhET  1) layak digunakan dengan nilai validasi dosen ahli media sebesar 82%, guru ahli materi sebesar 92% dengan kategori “sangat valid”. 2) dapat meningkatkan keterampilan berpikir kritis siswa dengan nilai  rata-rata N-Gain Score  sebesar 0.70 dengan  kategori “tinggi”. 3) respon siswa sebesar 90% dengan kategori “sangat positif”. Berdasarkan hasil penelitian dapat disimpulkan bahwa LKS berbasis virtual lab berbantuan simulasi PhET yang dikembangkan memunuhi kriteria valid dan dapat meningkatkan keterampilan berpikir kritis siswa, serta mendapat respon positif dari siswa.
PENGEMBANGAN MEDIA PEMBELAJARAN BERBASIS VIDEO PADA MATERI MOMENTUM DAN IMPULS PADA MASA PANDEMI COVID-19 DI SMA NEGERI I DEWANTARA ACEH UTARA
Authors: Sakdiah Halimatus , Putri Syurvani Else , Dewi Rozanna
Published: June 2022

Media video pembelajaran adalah media yang menyajikan audio dan visual yang berisi pesan-pesan pembelajaran baik yang berisi konsep, prinsip, prosedur, teori aplikasi pengetahuan untuk membantu pemahaman terhadap suatu materi pembelajaran. Penelitan ini bertujuan untuk mengetahui hasil validitas ahli dan respon siswa terhadap pengembangan media pembelajaran berbasis video pada materi momentum dan implus pada masa pandemi Covid-19 di SMA Negeri I Dewantara Aceh Utara. Sampel dalam penelitian ini adalah peserta didik kelas x mipa 1 dan x mipa 2. Penelitian ini menggunakan metode R&D dengan model pengembangan 4-D yaitu define, design, develop, disseminate. Telah dilakukan uji validitas oleh para ahli serta uji coba lapangan kepada siswa. Berdasarkan hasil validasi yang dilakukan oleh ahli materi memperoleh rata-rata sebesar 87.45% dengan kategori “sangat layak”, validasi ahli media memperoleh rata-rata sebesar 89.81% dengan kategori “sangat layak” dan hasil respon siswa 98.08% dengan kategori “sangat layak”. Maka dapat disimpulkan bahwa media pembelajaran berbasis video dinyatakan sangat layak dan dapat digunakan dalam pembelajaran.
PENGARUH MODEL PEMBELAJARAN MAKE A MATCH TERHADAP KETERAMPILAN BERPIKIR KREATIF SISWA SMA NEGERI 2 PEUSANGAN
Authors: Faradhillah Faradhillah , Jannah Wirdatul , Syafrizal Syafrizal
Published: June 2022

Penelitian ini bertujuan untuk mengetahui adanya pengaruh yang signifikan pada penerapan model pembelajaran make a match terhadap keterampilan berpikir kreatif siswa pada konsep gerak lurus kelas X SMA Negeri 2 Peusangan. Jenis penelitian ini adalah Quasi Eksperimen dengan rancangan Nonequivalent Control Group Design. Pengambilan data dilakukan di kelas X IPA 1 sebagai kelas eksperimen dengan jumlah 30 siswa sedangkan kelas X IPA 2 sebagai kelas kontrol dengan jumlah 32 siswa dengan menggunakan teknik purposive sampling. Berdasarkan data uji independent sample t test menggunakan aplikasi SPSS ver. 2016 diperoleh nilai signifikan (2-tailed) sebesar 0,015 < 0,05 maka H0 ditolak dan H1 diterima. Hal ini menunjukkan bahwa terdapat pengaruh model pembelajaran Make a Match terhadap keterampilan berpikir kreatif siswa pada materi gerak lurus di SMA Negeri 2 Peusangan.
IMPLEMENTASI ASESMEN AUTENTIK PADA MATA PELAJARAN FISIKA DI SMAN 1 SUNGAI PENUH
Authors: Agustina Ulan , Fadrina Saputri Fadrina , Sepriyanti Eny , Hidayat M
Published: June 2022

Penelitian ini bertujuan untuk 1)mengetahui pelaksanaan asesmen autentik di SMAN 1 Sungai Penuh, 2)mengetahui faktor pendukung asesmen autentik dan 3)faktor penghambat asesmen autentik. kegiatan penelitian ini dilaksanakan pada semester ganjil tahun pelajaran 2021, dengan subjek penelitian yaitu siswa 10 Mipa 2 dan 10 Mipa 5. Penelitian ini dilakukan dengan menggunakan metode deskriptif kualitatif melalui wawancara dan observasi. Wawancara dilakukan terhadap dua orang guru fisika di SMAN1 Sungai Penuh  Ditemukan hasil bahwa SMAN 1 masih belum afektif dalam melaksanakan asesmen autentik. Masih banyak jenis-jenis asesmen autentik yang belum dilaksanakan dengan baik dan hal tersebut terjadi karena adanya beberapa faktor penghambat . Asesmen penilaian proyek, kinerja maupun portofolio membutuhkan waktu yang cukup maksimal dalam pelaksanaannya serta membutuhkan perencanaan kegiatan sebaik mungkin Tingkat kemampuan pemahaman siswa. Tingkat kemampuan pemahaman siswa berbeda-beda. Adapun solusi untuk menangani hal tersebut untuk praktikum atau penilaian kinerja ,proyek atau portofolio bisa dilakukan secara mandiri dirumah untuk meminimalisir waktu.
Seçici Lazer Ergitme (SLM) Yöntemi ile Üretilen AlSi10Mg Alaşımlı Parçalarda Kusurlar, Mekanik Özellikler ve Yüzey Pürüzlülüğü-Bir Araştırma
Authors: SİYAMBAŞ Yusuf , TURGUT Yakup
Published: June 2022

Metal esaslı eklemeli imalat, bir enerji kaynağı ile metalik tozun veya telin katman katman eritilmesi yoluyla üç boyutlu (3B) nesnelerin imal edildiği modern bir üretim sürecidir. Seçici lazer eritme (SLM) yöntemi, karmaşık ve hafif yapıların üretimine olanak sağladığından hem bilimsel hem de endüstriyel alanlarda kullanılmaktadır. AlSi10Mg alaşımı havacılık, otomotiv, denizcilik ve medikal endüstrilerin yanı sıra, özel tasarımlara ihtiyaç duyulan çeşitli uygulamalarda yaygın olarak kullanılmakta ve SLM araştırmalarında öne çıkan malzemelerden biri durumundadır. SLM yöntemi ile üretilen bir ürünün kalitesi, ergitme için gerekli olan enerji yoğunluğunu etkileyen imalat parametrelerinin (lazer gücü, tarama hızı, tarama mesafesi, katman kalınlığı) optimizasyonunu gerektirmektedir. Uygun olmayan imalat parametrelerinin kullanılması ile süreç gereği deformasyon mekanizmalarından kaynaklanan iç gerilmeler oluşmakta ve parça üzerinde çarpılma, çatlama ve boyutsal değişim meydana gelmektedir. Toz malzeme özellikleri, toz tabakasının düzgün olmayan dağıtımı, imalat sırasında deformasyon, lazer ışınındaki değişiklikler gibi değişkenler metalurjik gözeneklere neden olabilmektedir. İmalat sürecinde oluşan her türlü kusur nihai parçanın mekanik özellikleri ve yüzey kalitesi üzerinde olumsuz etkiye sahiptir. Bu çalışmada seçici lazer ergitme yöntemi ile AlSi10Mg alaşımından yüksek yoğunlukta, yüksek mukavemet özelliklerinde ve yüksek yüzey kalitesinde parçalar üretmek için literatürde yapılan çalışmalar araştırılarak elde edilen sonuçlar sunulmuştur. Araştırma sonucunda, enerji yoğunluğunun ürün kalitesi üzerinde daha belirleyici olduğu tespit edilmiştir. Ürünlerde en az gözeneklilik için ideal enerji yoğunluğunun 50-75 J/mm3 aralığında olduğu, eklemeli imalat ile üretilen AlSi10Mg alaşımlı parçaların döküm yöntemi ile üretilenlere kıyasla daha iyi mukavemet özelliği gösterdiği belirlenmiştir.
मथुरा संग्रहालय में संग्रहीत कुषाण कालीन ‘बोधिसत्व’ मूर्तियों का अध्ययन
Authors: Gupta Sunita , Chandra Umesh
Published: June 2022

उत्तर प्रदेश के मथुरा जनपद में स्थित पुरातात्विक संग्रहालय में कुषाणकालीन बोधिसत्व मूर्तियों को यहाँ के शिल्पी ने बड़ी ही दक्षता के साथ उकेरा है। इन मूर्तियों में शरीर को आकर्षित एवं सुडौल मॉशल युक्त दर्शाया है। स्पष्ट भाव-भंगिमायें, हल्का, सलवटदार वस्त्र उकेरा गया है। इन मूर्तियों में कलाकार ने सफेद चित्तीदार लाल बलुए पत्थर का प्रयोग किया है। कुषाण सम्राट कनिष्क, हुविष्क व बासुदेव का शासन काल मथुरा कला का ‘स्वर्णिम काल’ माना गया है।
Peningkatan Pengetahuan Kelompok Tani Aren melalui Pelatihan Usaha Gula Aren di Kabupaten Maros, Sulawesi Selatan
Authors: Makkarennu Makkarennu , Supratman Supratman , Yumeina Diyah
Published: June 2022

Palm sugar as one of the non-timber forest products commonly used by communities around the forest area to be processed into palm sugar that can be sold to make ends meet. Community service activities is carried out in one of the villages adjacent to the Hasanuddin University Educational Forest Village Rompegading Cenrana Maros District of South Sulawesi province. The purpose of the implementation of this activity is to increase the quality of palm sugar processers who are part of the Palm Sugar Farmer Group through training and mentoring. This is based on the problems faced by the group, namely the low knowledge of the community in the processing of palm sugar, production process, product diversification, packaging and marketing. The number of trainees as many as 20 people who are the target partners of the group Tani Moncong Jai. The implementation of the activity is carried out through several stages, namely the preparation stage, introduction of activities, implementation of training and evaluation stage. The external target that has been achieved is the improvement of participants' knowledge of the materials submitted. The results of the pre-test and post-test showed that there was a 30% increase in the knowledge of farm group members related to the handling of raw materials, 53% product diversification, and 34% marketing. In addition, there is a design of printed palm sugar that can be used to market their products.
Pemberdayaan Masyarakat Desa Karang Asem Timur dalam Optimalisasi Budi Daya Ikan dan Produk Olahannya
Authors: Arsyianti Laily Dwi , Hidayatulloh Furqon Syarief , Maulana Fajar
Published: June 2022

In early 2020, Karang Asem Timur Village received a grant from the Ministry of Marine Affairs in the form of a catfish farming system in buckets (budikdamber). This program is conducted by several business groups that are widely spread in the community. Many of the catfish farmers in Karang Asem Timur Village complain about the high cost of commercial feed which is commonly used, made the profits earned very insignificant and even tend to lose, thus need supervision. The IPB Serving Lecturer Program attempts to empower the people of Karang Asem Timur Village in optimizing fish farming activities and their processed products. This program as an extension of the Thematic Field Apprenticeship Lecture (KKN-T) program, partners with the catfish business group in Karang Asem Timur Village look for other feeding alternatives that are cheaper and have good nutritional content for catfish. In addition, the program also cooperates with youth organizations and family welfare empowerment to open business opportunities for processed catfish products and catfish cultured products. It is hoped that the progress and independence of the village economy can be achieved. The society eagerly participate and propose for the program to be continued gradually and sustainably in the near future.
Peningkatan Pengetahuan Petani melalui Penyuluhan Pascapanen Cabai pada Kelompok Tani Kebun Berseri, Bintaro, Jakarta Selatan
Authors: Nauly Dahlia , Gustia Helfi , Rosdiana Rosdiana , Yuningsih Siska , Dwiputro Hafiz
Published: June 2022

Chili is a perishable product which require farmers to maintain its freshness. Rotten chili can not be sold causing the profits to decrease. One way to minimize the damage level of post harvest agricultural products is by applying the Good Handling Practice (GHP) system. The application of GHP will reduce the risk of contamination of fresh chili during handling, packaging, storage and transportation. The objective of this activity is to increase Kebun Berseri farmer’s group knowledge, ability and skill in handling chili post harvest and processing activities. The method of implementing this activity was extension, demonstration and evaluation. Extension activity was conducted using lecturing method. The topic discussed was related to increasing the value added, processing techniques for commercially valuable chilies, packaging techniques and a broader marketing system. Demonstrations were conducted to improve the skills of farmer’s group members in applying Good Handling Practice (GHP) correctly. The results of the evaluation showed that from these activities, farmers gained additional knowledge and new technology related to post-harvest handling and processing of chilies into shredded and chili oil.
Nu-Covid Eduboard: Edukasi Pesan Gizi Seimbang dan Protokol Kesehatan pada Siswa MDA Al-Muhajirin di Kota Medan
Authors: Mulifajar Putri , Zhaki Marhabsyah , Nasution Muhammad Iqbal , Nirwani Hanny , Alin Mulki Nur , Fadhilla Fiskianda , Fathia Fani Nurul , Qurrotul’aini Nurul Fathi , Simanjuntak Megawati
Published: June 2022

The Covid-19 virus is a virus that spread quickly either directly or indirectly. Prevention of the Covid-19 virus can be accompanied by a strong immune system, namely by improving a healthy lifestyle with balanced nutritional foods. Nutrition education stands for an effort to increase knowledge of nutrition and eating behavior which is important for elementary school children. The media which common to use is a playing board that can help students to understand and recall what has been conveyed. Based on this reason, the Medan Kota 02 KKN-T group designed a program to increase understanding of nutrition to prevent Covid-19 among elementary students in MDA Al-Muhajirin, in Kota Matsum IV Village. The activity began by filling out a pre-test to find out student's knowledge before receiving education material. After that, continued with delivering nutrition and covid materials including an explanation of the balanced nutrition cone, then continued with the health protocol material, playing the board game by attaching food stickers to the picture of the balanced nutrition cone and matching the picture with the health protocol description. In the last session, all the students were asked to filling out the post-test. The impact of this program is that students understand and apply how to maintain healthy and balanced nutrition guidelines (PGS) and comply with prokes. The results indicated that the value of the participants from pre-test to post-test increased not too significantly, namely by 0.034, which could be caused by knowledge bias due to distraction. The distraction may be caused by the participants' unpreparedness in receiving the material, the class conditions that are not supportive, and the lack of initiative of the participants to take notes and understand the material provided. Nu-Covid eduboard may be an alternative program for increasing student knowledge about balanced nutrition guidelines and prokes in covid-19 pandemic situation.
PENGARUH STRUKTUR KEPEMILIKAN, TRANSAKSI PIHAK TERKAIT, DAN REPUTASI PERUSAHAAN TERHADAP MANAJEMEN LABA
Authors: Zaenal Fanani  , Sari Yunita
Published: June 2022

Perusahaan dikelola oleh manajer yang seringkali bukan pemilik perusahaan. Situasi ini pada akhirnya akan mengarah pada pemisahan kepemilikan dari manajemen dan dapat menciptakan konflik kepentingan antara manajer dan pemilik. Penelitian ini menguji pengaruh struktur kepemilikan, transaksi pihak terkait, dan reputasi perusahaan terhadap manajemen laba. Sampel penelitian ini terdiri dari perusahaan manufaktur sektor industri barang konsumsi makanan dan minuman yang terdaftar di BEI periode 2015-2019. Penelitian ini menggunakan uji saphiro wilk dan uji multikolinearitas. Penelitian ini menghasilkan korelasi negatif antara kepemilikan terkonsentrasi, kepemilikan manajerial dengan manajemen laba, serta korelasi positif antara kepemilikan keluarga, kepemilikan institusional, reputasi perusahaan dengan manajemen laba. Namun demikian, transaksi piutang pihak terkait, transaksi utang pihak terkait tidak berhubungan dengan manajemen laba.
INTELLECTUAL CAPITAL PERFORMANCE: EVIDENCE FROM TOURISM AND HOSPITALITY INDUSTRY
Authors: Angkasaputra Cindy Olivia , Aditya Arya Aji , Nur Azizah
Published: June 2022

The purpose of this study was to determine the impact of intellectual capital on financial performance in Indonesia's hotel, restaurant, and tourism industries between 2018 and 2020. Annual reports from www.idx.co.id for the years 2018 until 2020 were used as secondary data. The sampling method was purposive sasmpling, while the measurement of human capital using VAIC. As a result, the multiple linear regression analysis finds that structural and human capital employed have an effect on financial performance while human capital does not. Based on the analysis result, we can conclude that tourism and hospitality businesses should determine the strategic role of strategic resources within the organization, particularly intellectual capital, during COVID-19. This is bolstered by the hotel, restaurant, and tourism industries, all of which rely heavily on intangible assets.
PENGARUH HARGA SAHAM, UKURAN PERUSAHAAN, PROFITABILITAS, DAN LEVERAGE TERHADAP NILAI PERUSAHAAN MANUFAKTUR YANG TERDAFTAR DI BEI TAHUN 2018-2020
Authors: Samosir Ruth Chintya , Herlina Novita  , Rutmia  , Kristina Sarumaha  , Eliza Saragih
Published: June 2022

ABSTRAK

Nilai pada sebuah perusahaan merupakan bagian faktor penentu untuk investor agar berinvestasi atas modalnya, dan perusahaan akan disebut sebagai baik jika nilai perusahaan tersebut tinggi.Tujuannya dalam penelitian ini guna menjalankan analisis pengaruhnya Harga saham, Leverage, Ukuran perusahaan dan Profitabilitas terhadap Nilai perusahaan pada Perusahaan Manufaktur listing di BEI tahun 2018-2020. Populasinya sebanyak 75 dengan  225 sampel dari Perusahaan Manufaktur dikali 4 tahun dengan menggunakan metode kuantitatif dalam pengambilan sampel. Metode penelitian ini memakai regresi linear berganda. Skor dari hasil uji koefesien dari nilai Adjusted R Square senilai 0,123 berarti berarti bahwa 12,3% variasi nilai perusahan dapat dijelaskan dengan variabel independen, sementara sisa lainnya 87,7% dijelaskan dengan variabel lainnya diluar dari variabel yang diteliti.Secara simultan menunjukan bahwa secara signifikan harga saham, Leverage, Ukuran Perusahaan dan Profitabilitas mempengaruhi nilai perusahaan. Menunjukan bahwasannya secara parsial harga saham, Ukuran perusahaan dan Profitabilitas tidak mempengaruhi nilai perusahaan dengan signifikan, sedangkan Leverage mempengaruhi nilai perusahaan dengan signifikan.
OPINI AUDIT GOING CONCERN DAN FAKTOR-FAKTOR PENYEBABNYA
Authors: Widhiastuti Ni Luh Putu , Putu Diah Kumalasari
Published: June 2022

Penelitian ini bertujuan  untuk menganalisis faktor-faktor yang memengaruhi opini audit going concern dengan menggunakan data sekunder yang diperoleh dari laporan tahunan perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia periode 2019-2020. Pengujian regresi logistik dilakukan pada 224 sampel perusahaan menggunakan metode purposive sampling.  Hasil penelitian menunjukkan bahwa  profitabilitas dan opini audit tahun sebelumnya memiliki hubungan negatif dengan opini audit going concern. Namun demikian, total asset turnover, debt to asset ratio, debt to equity ratio, pertumbuhan perusahaan, kualitas audit dan ukuran perusahaan tidak memiliki hubungan signifikan dengan opini audit going concern. Dalam konteks ini, hasil penelitian ini mengimplikasikan bahwa profitabilitas dan opini audit tahun sebelumnya menjadi early warning dari auditor dalam memberikan opini going concern untuk menilai kesehatan keuangan dan  keberlangsungan perusahaan.
IoT applied to irrigation systems in agriculture: A usability analysis
Authors: Romero-Riaño Efrén , Galeano-Barrera Claudia , Guerrero César D. , Martinez-Toro Mauricio , Rico-Bautista Dewar
Published: June 2022

The Internet of Things favors using technological tools in rural environments thanks to the ability to connect to the Internet between devices that facilitate daily tasks. The research aims to evaluate the usability of the decision support system for irrigation in agriculture, AgroRIEGO, through the development of an IoT-based device. The sponsors of this project were the Ministry of Information and Communication Technologies and the Center of Excellence in the Internet of Things Appropriation (CEA-IoT) in Colombia. Among the methods used is the use of the heuristic evaluation technique, structured into 15 categories and 62 subcategories of assessment. This analysis was complemented by the contribution of a group of experts in the design and development of IoT applications and devices and agriculture to assess the system's attributes.
O Pensar Sacramental
Authors: Boff Leonardo
Published: June 2022

A pesquisa sobre a palavra sacramenturn-mysterium e seu respectivo horizonte de compreensão (cf. REB 34, 1974, 860-895) resultou na seguinte conclusão fundamental: um determinado modo de ver toda a realidade está à base do universo sacramental cristão. As duas palavras-chaves não constituem apenas uma doutrina teológica dos Padres, mas uma verdadeira estrutura de pensar e um modo de ver o mundo. Tentava-se captar, numa visão sintética, dimensões diferentes da realidade como o divino e o humano, o transcendente e o imanente, o imperceptível e o perceptível, o temporal e o eterno...
O Primeiro Sacerdote do Brasil
Authors: Willeke Venâncio
Published: June 2022

Os grandes vultos da nossa incipiente história pátria são quase desconhecidos. O primeiro sacerdote que veio na armada de Pedro Alvares Cabral para muitos não passa de figura decorativa a celebrar as duas missas campais da Baía Cabrália, perante os maravilhados Tupiniquins. Como Frei Henrique de Coimbra apenas de passagem para a índia estabelecesse o primeiro contato da Igreja Católica com os silvícolas da Bahia, dele tratam pouco os historiadores, quer brasileiros, quer portugueses. E alguns interpretam mal certos passos deste franciscano...