bluuebunny/crossref_metadata_2025 huggingface dataset:
A passagem e a presença dos Jê Meridionais por São Paulo e Paraná: uma reflexão etno-histórica
Authors: Mota Lúcio Tadeu
Published: October 2017

A presença de populações de filiação linguística Jê (Kaingang e Xokleng) no sul do Brasil tem sido objeto de reflexão de pesquisadores das diversas áreas do conhecimento. A produção científica sobre elas, que remonta ao final do século XIX, teve continuidade por todo o século XX e ampliou-se no início do século XXI. Estudos linguísticos e antropológicos vinculam os Kaingang e Xokleng aos Jê do Brasil Central devido a permanência de traços linguísticos e culturais. No entanto, entendemos que os Jê do Sul (Kaingang e os Xokleng) não vieram “prontos” do Brasil Central e difundiram aqui no Sul suas “essencialidades”. Histórica e antropologicamente os grupos étnicos não são entidades fechadas, não estão isolados por fronteiras rígidas sem interação com outros grupos, e suas etnicidades não são dadas previamente. Assim, nossa proposição é iniciar uma reflexão sobre esse processo sócio-histórico de ocupação dos territórios do planalto meridional do Brasil pelos Jê do Sul, realçando as relações socioculturais dos Kaingang e Xokleng entre si e com outras populações do entorno. Focalizaremos nossas observações nos territórios das duas margens dos rios Paranapanema/ Itararé e Itapirapuã/Ribeira, por entendermos que as possíveis passagens dos Jê para o sul ocorreram em pontos ao longo desses rios. Procurar-se-á evidenciar, nesses espaços, os marcadores de cultura material e os dados históricos, que nos  apontem os possíveis corredores de transposição dessas populações por São Paulo e Paraná. Utilizaremos a Etno-história como um método interdisciplinar, por entender que ele conjuga dados e procedimentos de várias disciplinas: história, antropologia, arqueologia, linguística, geografia, ecologia, e também porque valoriza as tradições orais e os etno-conhecimentos na construção de explicações sobre o passado das populações indígenas.
Complexidade e Ocupação do Planalto Sul-Brasileiro: Um olhar a partir de São José do Cerrito, Estado de Santa Catarina, Brasil.
Authors: Beber Marcus Vinícius
Published: October 2017

A Arqueologia do Planalto Sul Brasileiro tem tido uma onda de novos trabalhos e novas abordagens ao longo dos últimos vinte anos, novas propostase novos enfoques tem permitido rediscutir antigos paradigmas, modelos interpretativos e a compreensão dos fenômenos identificados. Procurou-se aqui, discutir, parte desses modelos a partir de dois enfoques: primeiro uma revisão dos trabalhos já produzidos e por outra a retomada das pesquisas na Área Arqueológicade São José do Cerrito, SC. A partir dessa abordagem, foi possível lançar novas luzes sobre a discussão de emergência de complexidade entre as populações Jê meridionais.
News from the field ou como um projeto internacional começa a sair do papel
Authors: Corteletti Rafael , Souza Jonas Gregório , Cárdenas Macarena L. , Robinson Mark , Fradley Michael , Farias Deisi Scunderlick , Iriarte José , Mayle Frank , DeBlasis Paulo
Published: October 2017

O presente texto apresenta as questões centrais de pesquisa do projeto Paisagens Jê do Sul do Brasil e também traz resultados preliminares do primeiro ano de atividades de pesquisa em Arqueologia e Paleoecologia.
Estratégias de assentamento: uma análise sobre o sítio arqueológico Rincão dos Albinos, Planalto de Santa Catarina – Brasil
Authors: Novasco Raul Viana , Schmitz Pedro Ignácio
Published: October 2017

O presente trabalho tem como objetivo apresentar uma proposta de interpretação sobre o processo de formação do sítio arqueológico Rincão dos Albinos, elaborada a partir de resultados obtidos através de escavações arqueológicas e análises cartográficas. O referido sítio arqueológico está localizado no município de São José do Cerrito, planalto sul de Santa Catarina, e é composto por 107 casas subterrâneas de dimensões diversas, agrupadas em dois núcleos principais, ocupando uma área total de aproximadamente 6 hectares. Através das escavações arqueológicas, principalmente a partir de dados estratigráficos e cronológicos, foram obtidas informações parciais a respeito do processo de formação do sítio que, conforme sugerem as datas obtidas, tem início há 1.400 anos AP e se estende até 800 anos AP. No decorrer desta ocupação, estratégias de assentamento e uso do espaço foram desenvolvidas e, por meio de levantamentos topográficos, foi possível identificar elementos que nos permitem inferir a existência de variáveis que interferiram nas escolhas feitas pelos construtores das casas subterrâneas, em relação a sua localização e dispersão.
Influence of Intramyocardial Adipose Tissue on the Accuracy of Endocardial Contact Mapping of the Chronic Myocardial Infarction Substrate
Authors: Samanta Rahul , Kumar Saurabh , Chik William , Qian Pierre , Barry Michael A. , Al Raisi Sara , Bhaskaran Abhishek , Farraha Melad , Nadri Fazlur , Kizana Eddy , Thiagalingam Aravinda , Kovoor Pramesh , Pouliopoulos Jim
Published: October 2017

Background:

Recent studies have demonstrated that intramyocardial adipose tissue (IMAT) may contribute to ventricular electrophysiological remodeling in patients with chronic myocardial infarction. Using an ovine model of myocardial infarction, we aimed to determine the influence of IMAT on scar tissue identification during endocardial contact mapping and optimal voltage-based mapping criteria for defining IMAT dense regions.

Method and Results:

In 7 sheep, left ventricular endocardial and transmural mapping was performed 84 weeks (15–111 weeks) post-myocardial infarction. Spearman rank correlation coefficient was used to assess the relationship between endocardial contact electrogram amplitude and histological composition of myocardium. Receiver operator characteristic curves were used to derive optimal electrogram thresholds for IMAT delineation during endocardial mapping and to describe the use of endocardial mapping for delineation of IMAT dense regions within scar. Endocardial electrogram amplitude correlated significantly with IMAT (unipolar
r
=−0.48±0.12,
P
<0.001; bipolar
r
=−0.45±0.22,
P
=0.04) but not collagen (unipolar
r
=−0.36±0.24,
P
=0.13; bipolar
r
=−0.43±0.31,
P
=0.16). IMAT dense regions of myocardium reliably identified using endocardial mapping with thresholds of <3.7 and <0.6 mV, respectively, for unipolar, bipolar, and combined modalities (single modality area under the curve=0.80,
P
<0.001; combined modality area under the curve=0.84,
P
<0.001). Unipolar mapping using optimal thresholding remained significantly reliable (area under the curve=0.76,
P
<0.001) during mapping of IMAT, confined to putative scar border zones (bipolar amplitude, 0.5–1.5 mV).

Conclusions:

These novel findings enhance our understanding of the confounding influence of IMAT on endocardial scar mapping. Combined bipolar and unipolar voltage mapping using optimal thresholds may be useful for delineating IMAT dense regions of myocardium, in postinfarct cardiomyopathy.
Large Genomic Rearrangements of Desmosomal Genes in Italian Arrhythmogenic Cardiomyopathy Patients
Authors: Pilichou Kalliopi , Lazzarini Elisabetta , Rigato Ilaria , Celeghin Rudy , De Bortoli Marzia , Perazzolo Marra Marina , Cason Marco , Jongbloed Jan , Calore Martina , Rizzo Stefania , Regazzo Daniela , Poloni Giulia , Iliceto Sabino , Daliento Luciano , Delise Pietro , Corrado Domenico , Van Tintelen J. Peter , Thiene Gaetano , Rampazzo Alessandra , Basso Cristina , Bauce Barbara , Lorenzon Alessandra , Occhi Gianluca
Published: October 2017

Background:

Arrhythmogenic cardiomyopathy (AC) is an inherited heart muscle disease associated with point mutations in genes encoding for cardiac desmosome proteins. Conventional mutation screening is positive in ≈50% of probands. Copy number variations (CNVs) have recently been linked to AC pointing to the need to determine the prevalence of CNVs in desmosomal genes and to evaluate disease penetrance by cosegregation analysis in family members.

Methods and Results:

A total of 160 AC genotype-negative probands for 5 AC desmosomal genes by conventional mutation screening underwent multiplex ligation-dependent probe amplification. Nine heterozygous CNVs were identified in 11 (6.9%) of the 160 probands. Five carried a deletion of the entire plakophilin-2 (
PKP2
) gene, 2 a deletion of only
PKP2
exon 4, 1 a deletion of the
PKP2
exons 6 to 11, 1 a
PKP2
duplication of 5′ untranslated region till exon 1, 1 the desmocollin-2 (
DSC2
) duplication of exons 7 to 9, and 1 a large deletion of chromosome 18 comprising both
DSC2
and
desmoglein-2
genes. All probands were affected by moderate-severe forms of the disease, whereas 10 (32%) of the 31 family members carrying one of these deletions fulfilled the diagnostic criteria.

Conclusions:

Genomic rearrangements were detected in ≈7% of AC probands negative for pathogenic point mutations in desmosomal genes, highlighting the potential of CNVs analysis to substantially increase the diagnostic yield of genetic testing. Genotype–phenotype correlation demonstrated the presence of the disease in about one third of family members carrying the CNV, underlying the role of other factors in the development and progression of the disease.
Mechanisms for the Maintenance of the Wintertime Basin-Scale Atmospheric Response to Decadal SST Variability in the North Pacific Subarctic Frontal Zone
Authors: Okajima Satoru , Nakamura Hisashi , Nishii Kazuaki , Miyasaka Takafumi , Kuwano-Yoshida Akira , Taguchi Bunmei , Mori Masato , Kosaka Yu
Published: October 2017

Mechanisms for the maintenance of a large-scale wintertime atmospheric response to warm sea surface temperature (SST) anomalies associated with decadal-scale poleward displacement of the North Pacific subarctic frontal zone (SAFZ) are investigated through the following two ensemble experiments with an atmospheric general circulation model (AGCM): one with climatological-mean SST and the other with positive SST anomalies along the SAFZ prescribed on top of the climatological-mean SST. As actually observed, the simulated January ensemble response over the North Pacific is anticyclonic throughout the depth of the troposphere, although its amplitude is smaller. This response is maintained through energy conversion from the ensemble climatological-mean circulation realized under the climatological SST as well as feedback from anomalous transient eddy activity, suggesting that the response may have characteristics as a preferred mode of variability (or “dynamical mode”). Conversions of both available potential energy and kinetic energy from the climatological-mean state are important for the observed anomaly, while the latter is less pronounced for the model response. Net transient feedback forcing is also important for both the observed anomaly and simulated response. These results imply that a moderate-resolution (~1°) AGCM may be able to simulate a basin-scale atmospheric response to the SAFZ SST anomaly through synoptic- and basin-scale dynamical processes. Weaker PNA-like internal variability in the model may lead to the weaker response, suggesting that misrepresentation of intrinsic atmospheric variability can affect the model response to the SST anomaly.
Toward a Polarimetric Radar Classification Scheme for Coalescence-Dominant Precipitation: Application to Complex Terrain
Authors: Porcacchia Leonardo , Kirstetter P. E. , Gourley J. J. , Maggioni V. , Cheong B. L. , Anagnostou M. N.
Published: October 2017

Accurate quantitative precipitation estimation over mountainous basins is of great importance because of their susceptibility to natural hazards. It is generally difficult to obtain reliable precipitation information over complex areas because of the scarce coverage of ground observations, the limited coverage from operational radar networks, and the high elevation of the study sites. Warm-rain processes have been observed in several flash flood events in complex terrain regions. While they lead to high rainfall rates from precipitation growth due to collision–coalescence of droplets in the cloud liquid layer, their characteristics are often difficult to identify. X-band mobile dual-polarization radars located in complex terrain areas provide fundamental information at high-resolution and at low atmospheric levels. This study analyzes a dataset collected in North Carolina during the 2014 Integrated Precipitation and Hydrology Experiment (IPHEx) field campaign over a mountainous basin where the NOAA/National Severe Storm Laboratory’s X-band polarimetric radar (NOXP) was deployed. Polarimetric variables are used to isolate collision–coalescence microphysical processes. This work lays the basis for classification algorithms able to identify coalescence-dominant precipitation by merging the information coming from polarimetric radar measurements. The sensitivity of the proposed classification scheme is tested with different rainfall-rate retrieval algorithms and compared to rain gauge observations. Results show the inadequacy of rainfall estimates when coalescence identification is not taken into account. This work highlights the necessity of a correct classification of collision–coalescence processes, which can lead to improvements in quantitative precipitation estimation. Future studies will aim at generalizing this scheme by making use of spaceborne radar data.
Effects of thermal gradients on defect formation during the consolidation of partially impregnated prepregs
Authors: Centea T , Peters G , Hendrie K , Nutt SR
Published: October 2017

We describe the effects of thermal gradients on the consolidation of partially impregnated prepregs. Laminates were cured on a heated tool in isothermal and nonisothermal conditions. Key process parameters were varied, including thermal gradient magnitude, air evacuation direction, and vacuum quality. Laminate quality was assessed using microscopy of polished cross-sections and X-ray computed tomography, and interpreted relative to the evolution of resin and prepreg properties during cure. The results show that thermal gradients influenced the rate of impregnation of the prepreg and the rate of gas transport, and affected the amount and distribution of porosity when air was not fully evacuated. Temperature distributions that led to cold regions at the ply boundaries were advantageous, typically exhibiting lower porosity than isothermal baselines. Conversely, gradients resulting in hotter-than-average part perimeters effectively sealed air within the laminate, degrading quality. The results clarify fundamental defect formation mechanisms for partially impregnated prepregs and other processes reliant on air evacuation through an unsaturated preform and provide guidelines for part, tool, and process design.
External Versus Two Different Internal Foci of Attention in Long-Distance Throwing
Authors: Oki Yuta , Kokubu Masahiro , Nakagomi Shiro
Published: October 2017

The present study examined the influence of attentional focus on performance during a long-distance throwing task. Twelve participants executed three maximum-effort, long-distance baseball throwing attempts in three focus conditions: internal focus on wrist flexion (wrist internal focus), internal focus on the separation between pelvis and upper torso orientations (torso internal focus), and external focus on the ball path (external focus). Compared with the external focus and torso internal focus conditions, performance was poorer in the wrist internal focus condition. Performances were not different in the torso internal and external focus conditions. In addition, attentional focus affected the release angle of the ball but not its initial velocity. Our results reveal that the body part targeted for internal focus of attention and the forcefulness of the motor activity can be as important to motor performance as whether the attention is internal or external.
Automated Sentiment Analysis in Tourism: Comparison of Approaches
Authors: Kirilenko Andrei P. , Stepchenkova Svetlana O. , Kim Hany , Li Xiang (Robert)
Published: October 2017

Interest in applying Big Data to tourism is increasing, and automated sentiment analysis has been used to extract public opinion from various sources. This article evaluates the suitability of different types of automated classifiers for applications typical in tourism, hospitality, and marketing studies by comparing their performance to that of human raters. While the commonly used performance indices suggest that on easier-to-classify data sets machine learning methods demonstrate performance comparable to that by human raters, other performance measures such as Cohen’s kappa show that the results of machine learning are still inferior to manual processing. On more difficult and noisy data sets, automated analysis has poorer performance than human raters. The article discusses issues pertinent to selection of appropriate sentiment analysis software and offers a word of caution against using automated classifiers uncritically.
Experience Value Cocreation on Destination Online Platforms
Authors: Zhang Hongmei , Gordon Susan , Buhalis Dimitrios , Ding Xifen
Published: October 2017

Technology is critical for facilitating the experience value cocreation process in tourism. Online platforms in particular enable consumers to develop realistic expectations and to cocreate their experiences. Limited empirical research has been done to investigate the experience value cocreation process, especially in tourism. This study fills this gap by proposing a cognition–emotion–behavior model. A scenario experiment approach is used to investigate the experience value cocreation process on destination online platforms in the pretravel stage. Structural equation modeling analysis shows that online platform experience significantly affects the destination emotional experience. This, in turn, has significant effects on the five dimensions of destination engagement intention. The mediating effect of destination emotional experience on the relationship between online platform experience and destination engagement intention is supported. These findings contribute to a better understanding of the experience value cocreation process and theoretical and managerial implications are proposed.
Revisiting the Organized/Disorganized Model of Sexual Homicide
Authors: Mjanes Karin , Beauregard Eric , Martineau Melissa
Published: October 2017

This study examined the organized/disorganized model to determine if support exists for two discrete offender types among a sample of 350 Canadian cases of sexual homicide. Variables related to crime scene characteristics and the offender’s modus operandi were tested using latent class analyses. Results suggest that sexual murderers can be separated into two distinct profiles that share similarities with the organized/disorganized dichotomy in terms of the detection avoidance strategies, control, and type of violence used by the offender. The latent class results show further support for the FBI model in relation to the offender’s approach, sexual acts, and postmortem activities.
Infinite-dimensional disturbance-observer-based control for an axially moving non-uniform system with input constraint
Authors: Zhao Zhijia , Liu Yu , Luo Fei
Published: October 2017

In this paper, the vibration control and input saturation constraint problem of an axially moving non-uniform system subject to unknown disturbances is investigated. The key control objectives are to control the vibration of the system and eliminate the effects of the input saturation constraint. To that end, a boundary control with an auxiliary system is designed by utilizing Lyapunov’s direct method. Additionally, a boundary disturbance observer is proposed to deal with the boundary disturbance, and an infinite-dimensional disturbance observer is introduced to mitigate the effects of the distributed disturbance. With the designed boundary control, uniformly bounded stability of the controlled system is achieved through rigorous Lyapunov analysis without any model reduction. Finally, simulation results are given to show the effectiveness of the designed control scheme.
Effects on Cancellous Bone in the Metaphysis
Authors: Gropp Kathryn E.
Published: October 2017

Cancellous bone has high metabolic activity compared to many other bone compartments and can be affected not only by changes in physeal activity but also by perturbations in homeostasis caused by changes in physiology or on-target pharmacology. Examples of several types of resulting morphologic findings were presented; if known, the pathways causing morphologic changes were discussed.
Understanding Latino/a language brokers’ identity goals in association with parent–child relational quality
Authors: Pines Rachyl L. , Kam Jennifer A. , Bernhold Quinten
Published: October 2017

In the U.S., children of immigrant families often language broker—linguistically and culturally mediate for their family and members of U.S. mainstream culture. Previous research indicates that language brokering can have important implications for the parent–child relationship. Using survey data from 274 Latino/a sixth- to eighth-grade students, we examined how young brokers’ identity goals (i.e., “acting Latino/a” and “acting U.S. American”) and cultural identification are associated with parent–child relational closeness and parent–child destructive conflict management. Results showed that, in general, accommodating their parent by “acting Latino/a” was associated with higher relational quality for young language brokers who reported weak Latino/a cultural identification. Accommodating Latino/a parents’ cultural identity while language brokering might help improve parent–child relational quality for young Latino/a language brokers.
Combined transarterial chemoembolization and radiofrequency ablation for small treatment-naïve hepatocellular carcinoma infeasible for ultrasound-guided radiofrequency ablation: long-term outcomes
Authors: Hyun Dongho , Cho Sung Ki , Shin Sung Wook , Park Kwang Bo , Lee Sang Yub , Park Hong Suk , Do Young Soo
Published: October 2017

Background

Ultrasound (US)-guided radiofrequency ablation (RFA) for small hepatocellular carcinoma (HCC) is often infeasible due to unfavorable location and poor conspicuity. Those small HCCs can be treated with combined transarterial chemoembolization (TACE) and RFA.

Purpose

To evaluate long-term outcomes of combined TACE and RFA for small treatment-naïve HCC infeasible for US-guided RFA.

Material and Methods

Between February 2009 and January 2014, 69 patients with small (≤3 cm) HCC infeasible for US-guided RFA received TACE and subsequent RFA in one session as a first-line treatment. Local tumor progression (LTP), overall survival (OS), and event-free survival rates were evaluated. Univariate and multivariate analyses were conducted to identify prognostic factors.

Results

Cumulative rates of LTP were 4.4%, 6.8%, 8.2%, 9.5%, and 9.5% at one, two, three, five, and seven years, respectively. Cumulative one-, two-, three-, five-, and seven-year OS rates were 100%, 95%, 89%, 80%, and 80%, respectively. Cumulative one-, two-, three-, five-, and seven-year event-free survival rates were 81%, 63%, 54%, 31%, and 20%, respectively. No significant prognostic factors for LTP, OS, and event-free survival were identified in univariate analysis.

Conclusion

Combined TACE and RFA appears to be an effective treatment for small treatment-naïve HCC infeasible for US-guided RFA in terms of LTP and OS.
Auditory Pitch Perception in Autism Spectrum Disorder Is Associated With Nonverbal Abilities
Authors: Chowdhury Rakhee , Sharda Megha , Foster Nicholas E. V. , Germain Esther , Tryfon Ana , Doyle-Thomas Krissy , Anagnostou Evdokia , Hyde Krista L.
Published: October 2017

Atypical sensory perception and heterogeneous cognitive profiles are common features of autism spectrum disorder (ASD). However, previous findings on auditory sensory processing in ASD are mixed. Accordingly, auditory perception and its relation to cognitive abilities in ASD remain poorly understood. Here, children with ASD, and age- and intelligence quotient (IQ)-matched typically developing children, were tested on a low- and a higher level pitch processing task. Verbal and nonverbal cognitive abilities were measured using the Wechsler’s Abbreviated Scale of Intelligence. There were no group differences in performance on either auditory task or IQ measure. However, there was significant variability in performance on the auditory tasks in both groups that was predicted by nonverbal, not verbal skills. These results suggest that auditory perception is related to nonverbal reasoning rather than verbal abilities in ASD and typically developing children. In addition, these findings provide evidence for preserved pitch processing in school-age children with ASD with average IQ, supporting the idea that there may be a subgroup of individuals with ASD that do not present perceptual or cognitive difficulties. Future directions involve examining whether similar perceptual-cognitive relationships might be observed in a broader sample of individuals with ASD, such as those with language impairment or lower IQ.
On Bayesian Simplicity in Human Visual Perceptual Organization
Authors: van der Helm Peter A.
Published: October 2017

A returning idea among some Bayesians in research on human visual perceptual organization is that the surprisal of something (i.e., the negative logarithm of its probability) expresses its complexity (i.e., the length of its shortest description). Bayes’ rule is a powerful modeling tool and descriptive simplicity is a rich concept, but this idea is wishful thinking at best: If true, it would unify the simplicity and likelihood principles, which reflect two traditionally opposed schools of thought on perceptual organization. Some rapprochement between the two principles can certainly be discerned, but the aforementioned idea lacks formal underpinning and confounds otherwise perfectly good ideas. Here, this idea is revisited and its latest version is debunked step by step. In addition, I argue that its likely origin lies, inadvertently, in a standard Bayesian textbook: The author made (a) a pivotal mistake and (b) a compelling argument that was overinterpreted by others.
No funeral bells: Public reason in a ‘post-truth’ age
Authors: Jasanoff Sheila , Simmet Hilton R
Published: October 2017

The label ‘post-truth’ signals for many a troubling turn away from principles of enlightened government. The word ‘post’, moreover, implies a past when things were radically different and whose loss should be universally mourned. In this paper, we argue that this framing of ‘post-truth’ is flawed because it is ahistorical and ignores the co-production of knowledge and norms in political contexts. Debates about public facts are necessarily debates about social meanings, rooted in realities that are subjectively experienced as all-encompassing and complete, even when they are partial and contingent. Facts used in policy are normative in four ways: They are embedded in prior choices of which experiential realities matter, produced through processes that reflect institutionalized public values, arbiters of which issues are open to democratic contestation and deliberation, and vehicles through which polities imagine their collective futures. To restore truth to its rightful place in democracy, governments should be held accountable for explaining who generated public facts, in response to which sets of concerns, and with what opportunities for deliberation and closure.
Effect of pneumatic spreading on impregnation and fiber fracture of continuous fiber-reinforced thermoplastic composites
Authors: Ren Feng , Yu Yang , Cao Minghua , Li Ying , Xin Chunling , He Yadong
Published: October 2017

The fiber pre-spreading is of great importance when the continuous fiber-reinforced thermoplastic composites are produced by the melt impregnation process. In this paper, an improved spreading device is introduced, in which via grooving the pins for the airflow, the fiber is pre-spread by the combination of the airflow and the rolls. The objective of this operation is to reduce the contact friction between the fiber bundle and the pins surface, thereby reducing fiber fracture during the pre-spreading process. The influence of airflow on the pre-spreading of the fiber bundle is also investigated in this paper. It is found that the effect of airflow on the impregnation is significant and the fiber fracture rate is reduced effectively by analyzing the water absorption rate, interlayer shear strength and fiber fracture rate of the prepreg. When the air pressure is 0.2 MPa, the performance of the prepreg is optimal.
Point-of-Care Testing in Community Pharmacies: Keys to Success From Pennsylvania Pharmacists
Authors: Steltenpohl Emily A. , Barry Brandon K. , Coley Kim C. , McGivney Melissa S. , Olenak Julie L. , Berenbrok Lucas A.
Published: October 2017

Background

Clinical Laboratory Improvement Amendments (CLIA)-waived tests allow for quick, accurate, and noninvasive laboratory testing. Community pharmacists utilize CLIA-waived tests to provide clinical services such as point-of-care (POC) testing to help manage chronic disease and acute illness.

Objective

To identify key themes in the successful delivery of POC testing services by community pharmacists in Pennsylvania.

Results

An initial search identified 51 Pennsylvania pharmacies with a CLIA waiver. Of these, five independent pharmacies met inclusion criteria, three of which completed interviews. The remaining 38 chain pharmacies were represented by three interviews. In total, five key themes were identified as essential to POC testing services: (1) utilize state resources and professional connections to navigate federal and state regulations, (2) establish relationships with physician partners (3) offer tests that are meaningful to patients and their physicians, (4) evaluate financial impact, workflow adaptations, and marketing approaches when implementing POC testing services, and (5) focus on individualized attention and convenience of community pharmacy-based POC testing to improve patient satisfaction.

Conclusion

Successful POC testing services in community pharmacy practice rely on utilizing resources, partnering with known physicians, selecting meaningful tests for patients, and analyzing finances, workflow, and marketing to provide individualized attention and convenient care.
Study on the micro-scale effect in the micro–nano organic pores of a shale reservoir
Authors: Wu Zisen , Dong Pingchuan , Lei Gang , Cao Nai , Li Yudan , Wang Yifan , Zhang Xuejiao
Published: October 2017

The micro-scale effect occurs because of the gas flows in shale reservoirs containing small organic pores. In this study, based on a lattice Boltzmann model incorporating the bounce-back and specular-reflection boundary conditions, the gas flow through two parallel plates driven by differential pressures is simulated, which in turn verifies the model. Considering the effects of the slippage, surface diffusion, and adsorption, the gas flow in the organic channels is simulated based on the proposed lattice Boltzmann model. It is shown that the micro-scale effect is significant in the gas flows in the micro-scale channels. The compression effect leads to a nonlinear distribution of pressures along the centreline of the flow channels, and the nonlinearity increases with an increase in the pressure difference between the two sides of the flow channel. In case of gas flows in organic pores, the adsorption effect decreases the free-gas velocities, and with a decrease in pore sizes, the average free-gas velocity is reduced owing to the increased adsorption effect. The slippage effect and surface diffusion have a significant impact on the free-gas velocity of the mass flow. Compared to the slippage effect, surface diffusion contributes more to the mass flow of gas in organic pores. An increase in the Knudsen number intensifies the slippage effect and surface diffusion and enhances the mass flow.
Prediction of bearing damage in wind turbines based on the quadratic root mean square of sub-band manifold
Authors: Guangbin Wang , Moujun Du , Liangpei Huang , Long Li
Published: October 2017

When a high-power wind turbine runs in normal status, and if bearing current exists for a long time, multiple point corrosion would occur and gradually increase, eventually forming a ripple groove on the inner ring race, outer ring race and rolling body. It would lead to more vibration and shock, thereby causing fault in the equipment; the best way to prevent the this kind of fault is to find the effective fault characteristics and predict the damage’s degree on the bearing. In this paper, an adaptive neural network prediction method based on the quadratic root mean square of sub-band manifold is proposed. The damage characteristics can be analyzed by following steps: firstly, the vibration signal is decomposed into multidimensional time frequency space by wavelet packet method. Secondly, the sub-band of the manifold is constructed. The third step is to extract the root mean square value. Finally, the damage characteristics of the bearing current of the two square root sub-band manifold are obtained. Based on the back propagation network, the adaptive prediction model is built, and the training speed could be adjusted automatically according to the prediction error and precision. According to the bearing’s fault mechanism with current damage on the high-power wind turbine, one fault experiment platform has been built to simulate the current damage process of the bearing and verify the prediction method based on the quadratic root mean square of sub-band manifold. The experimental results show that the method can effectively predict the degree of bearing current damage, and the relative error of prediction is less than 5%.
LncRNA HOXA11-AS promotes proliferation and invasion by targeting miR-124 in human non–small cell lung cancer cells
Authors: Yu Wanjun , Peng Weidong , Jiang Hao , Sha Hanyun , Li Jipeng
Published: October 2017

Long non-coding RNAs have been implicated in human cancer but their mechanisms of action are mainly undocumented. In this study, we found that HOXA11-AS expression was upregulated in non–small cell lung cancer tissues and cell lines. High levels of HOXA11-AS expression were correlated with larger tumor size and lymph node metastasis. Functional analysis revealed that HOXA11-AS promotes non–small cell lung cancer cell proliferation and invasion. In particular, HOXA11-AS functions as a competing endogenous RNA to regulate transcriptional factor Sp1 expression via sponging miR-124. Collectively, our findings reveal an oncogenic role for HOXA11-AS in non–small cell lung cancer tumorigenesis.
Arbitrary ministerial power under the Migration Act: Permanent residents beware!
Authors: Hilkemeijer Anja
Published: October 2017

Under recent amendments to the Migration Act, the Minister for Immigration and Border Protection may cancel or refuse a visa if they suspect that a person belongs to a group, other members of which they suspect are involved in criminal conduct. A visa may be cancelled without first hearing the person affected and there is only limited opportunity for judicial review: confidential police and intelligence information forming the basis of the decision may be withheld from both the person affected and the Court. The operation of this set of statutory powers diminishes the rule of law in Australia. This is demonstrated by examining the 2016 Federal Court of Australia’s decision in Roach v Minister for Immigration and Border Protection [2016] FCA 750 in light of Martin Krygier’s definition of arbitrary power .
Treatment history and antimicrobial susceptibility results for Mannheimia haemolytica, Pasteurella multocida, and Histophilus somni isolates from bovine respiratory disease cases submitted to the Iowa State University Veterinary Diagnostic Laboratory from 2013 to 2015
Authors: Magstadt Drew R. , Schuler Adlai M. , Coetzee Johann F. , Krull Adam C. , O’Connor Annette M. , Cooper Vickie L. , Engelken Terry J.
Published: October 2017

Bovine respiratory disease is the most costly disease facing the cattle industry. Increasing resistance to antimicrobial treatment has been presented as a significant contributing factor, often through summarized susceptibility testing data. We assessed the relationship between previous antimicrobial treatment and antimicrobial susceptibility results from isolates of Mannheimia haemolytica, Pasteurella multocida, and Histophilus somni cultured from bovine respiratory cases submitted to the Iowa State University Veterinary Diagnostic Laboratory from 2013 to 2015. Antimicrobial susceptibility data from 1,251 bacterial isolates were included for analysis. More bacterial isolates from cattle that received antimicrobial treatment showed resistance compared to isolates from untreated cattle, and the percentage of resistant isolates increased as the number of antimicrobial treatments increased. Resistance to enrofloxacin, spectinomycin, tilmicosin, and tulathromycin was present in >75% of M. haemolytica isolates from cattle that had received 3 or more antimicrobial treatments; resistance to each of those 4 antimicrobials was present in ≤10% of M. haemolytica isolates from untreated cattle. Similar but less dramatic trends were apparent for isolates of P. multocida and H. somni. The percentage of multi-drug resistant bacterial isolates also increased with the number of treatments. Results of our study suggest that previous antimicrobial treatment may have a profound effect on antimicrobial susceptibility testing. Summarized susceptibility results from diagnostic laboratories should not be used to make generalized statements regarding trends in antimicrobial resistance without providing context regarding antimicrobial treatment history.
Magnetorheological properties and polishing characteristics of silica-coated carbonyl iron magnetorheological fluid
Authors: Hong Kwang Pyo , Song Ki Hyeok , Cho Myeong Woo , Kwon Seung Hyuk , Choi Hyoung Jin
Published: October 2017

While magnetorheological fluids can be used for ultra-precise polishing, for example, of advanced optical components, oxidation of metallic particles in water-based magnetorheological fluids causes irregular polishing behavior. In this study, carbonyl iron microspheres were initially coated with silica to prevent oxidation and were used to polish BK7 glass. In addition, their rheological and sedimentation characterizations were investigated. Material removal and surface roughness were analyzed to investigate the surface quality and optimal experimental conditions of polishing wheel speed and magnetic field intensity. The maximum material removal was 0.95 µm at 95.52 kA/m magnetic field intensity and 1854 mm/s wheel speed. A very fine surface roughness of 0.87 nm was achieved using the silica-coated magnetorheological fluid at 47.76 kA/m magnetic field intensity and 1854 mm/s wheel speed.
Size-dependent electro-elastic analysis of a sandwich microbeam based on higher-order sinusoidal shear deformation theory and strain gradient theory
Authors: Arefi Mohammad , Zenkour Ashraf M
Published: October 2017

The governing equations of bending analysis of a sandwich microbeam are derived in this article. The sandwich microbeam includes an elastic micro-core and two piezoelectric micro face-sheets. The microbeam is subjected to transverse loads and two-dimensional electric potential. Higher-order sinusoidal shear deformation beam theory is used for description of displacement field. To account for size dependency in governing equations of bending, strain gradient theory is used to mention higher-order stress and strains. An analytical approach for simply supported sandwich microbeam with short-circuited electric potential is proposed. The numerical results indicate that various types of parameters such as foundation, material and loads parameters have significant effect on the bending results. Comparison of valid references is performed to validate our numerical results. The numerical results indicate that maximum displacement and electric potential are approximately insensitive to applied voltage unlike to beam rotation and beam higher-order rotation of sandwich microbeam that are changed with applied voltage.
Masculinities Representations Inventory (MRI, English Version): A Measure of Gender (Re)Presentation
Authors: Luyt Russell
Published: October 2017

This article introduces the Masculinities Representations Inventory (MRI), English version, as a multidimensional measure of gender (re)presentation. It provides structural, convergent, and divergent validity, as well as reliability evidence, in support of its use among English speakers in South Africa. Principal components analysis with a male student sample ( n = 319) confirms the measure’s construct multidimensionality. Three factors inform a 29-item total- and subscale measure, including dominant Representations of Othering (Anti-Effeminacy and Homo-Negativity), Responsibility (Dependability and Success), and Control (Dominance and Toughness). Evidence of convergent validity is seen in predicted patterns of correlation between MRI scale scores and those of the Male Role Norms Inventory as well as Gender Role Conflict Scales. Evidence of divergent validity is apparent in nonsignificant correlations, in all but one case (Masculinity), with the Personal Attributes Questionnaire scale scores.
Single-Surgeon Experience and Complications of a Fixed-Bearing Total Ankle Arthroplasty
Authors: Pangrazzi Garett J. , Baker Erin A. , Shaheen Phillip J. , Okeagu Chikezie N. , Fortin Paul T.
Published: October 2017

Background:

Total ankle arthroplasty (TAA) has historically resulted in inferior survivorship rates compared with total hip and knee arthroplasty, because of technical issues unique to ankle anatomy. In this study, a single-surgeon series of intra- and postoperative complications as well as resultant reoperations/revisions of the Tornier Salto Talaris, a fixed-bearing TAA prosthesis, were reviewed.

Methods:

Medical records from index procedure to latest follow-up of primary TAA were reviewed. Complications were categorized according to the Glazebrook classification; additional complications were documented. Concurrent procedures were recorded, and radiographs were analyzed for alignment, subsidence, and cyst formation. Time to complication onset and learning curve analyses were performed. One hundred four Salto Talaris TAA prostheses (96 patients), with an average follow-up of 46 months, were included.

Results:

Thirty-five complications were identified in 32 ankles with a 34% complication rate, resulting in 11 reoperations (5 TAA revisions). Technical error (n = 12), wound healing (n = 9), and aseptic loosening (n = 4) were the most common complications, and there were no statistically significant differences in demographics or follow-up duration between cases with versus without complications. In both the cohorts with and without complications, there were moderate, negative correlations between radiographically observed keel osteopenia and lucency (ρ = −0.548, P = .00125, and ρ = −0.416, P = .000303, respectively); also, in the complication cohort, a weak, positive correlation between subsidence and lucency (ρ = 0.357, P = .0450) was found.

Conclusion:

Salto Talaris TAA survivorship and reoperation rates in our series were comparable with previous reports, using either the same or similar mobile-bearing prostheses; new information regarding complication, radiographic, and learning curve analyses was presented.

Level of Evidence:

Level IV, retrospective case series.
Pregnancy and Childbearing Among Young Adults Who Experienced Foster Care
Authors: Combs Katie Massey , Begun Stephanie , Rinehart Deborah J. , Taussig Heather
Published: October 2017

This study explores rates of early pregnancy and parenthood among a sample of young adults ( N = 215), ages 18–22, with a history of foster care. The study also compares the educational attainment, financial resources, and homelessness experiences of young adults who became parents to those who did not. By age 21, 49% of the young women became pregnant, and 33% of young men reported getting someone pregnant. Over a quarter of participants experienced parenthood, which was associated with lower educational attainment, less employment, not having a checking or savings account, and a history of homelessness. Gender moderated the association between parenthood and employment such that males who were parents were more likely than female parents to be employed. Given that these young adults were at risk of early pregnancy and parenthood regardless of emancipation status and across several racial/ethnic groups, the results suggest a need for early pregnancy prevention efforts for all youth with child welfare involvement as well as improving resources and support for those who become young parents.
Mobilizing Dis/Ability Research: A Critical Discussion of Qualitative Go-Along Interviews in Practice
Authors: Castrodale Mark Anthony
Published: October 2017

In this article, I document the challenges of operationalizing critical qualitative mobile research methods, specifically go-along interviews. Mobility-oriented qualitative inquiry is a way to examine disabled and Mad persons’ socio-spatial knowledges and study spatial inequalities impacting these persons. I reflect on my own positionality as an able-bodied researcher, while conducting research with self-identifying Mad and disabled research participants. I further discuss the limitations, enabling factors, constraints, and implications of engaging in go-along interviews. Next, I unpack how and why this method at many times was not desired by my research participants in favor of more traditional interview techniques, such as sit-down face-to-face interviews. There is a need to critically (re)consider space and place in research practices in ways that value the often subjugated voices and socio-spatial knowledge(s) of Mad and disabled persons.
Pleuroperitoneal Communication and Ovarian Cancer Complicating Peritoneal Dialysis: A Case Report of a Patient with End-Stage Kidney Disease
Authors: Akimoto Tetsu , Yamazaki Tomoyuki , Kohara Marina , Nakagawa Saki , Kanai Yoshihiko , Izawa Sayoko , Yamamoto Hisashi , Nakazawa Eiko , Masuda Takahiro , Kobayashi Takahisa , Saito Osamu , Muto Shigeaki , Kusano Eiji , Nagata Daisuke
Published: October 2017

Peritoneal dialysis has been a widely accepted modality for treating end-stage kidney disease, but a regular dialysis schedule can be seriously disrupted by various comorbid conditions requiring surgical intervention. A 40-year-old woman who had been receiving peritoneal dialysis was sequentially but separately complicated by pleuroperitoneal communication and ovarian cancer. Despite the need for temporary interruption of her peritoneal dialysis schedule, it was successfully resumed after the relevant surgeries for each disease. Several concerns regarding overall postoperative dialytic management strategies, including how to deal with the peritoneal dialysis catheter during the postoperative period as well as how long peritoneal dialysis should be interrupted, which remain an unresolved issue in the field of nephrology, are also discussed.