bluuebunny/crossref_metadata_2025 huggingface dataset:
Spike threshold adaptation diversifies neuronal operating modes in the auditory brain stem
Authors: Lubejko Susan T. , Fontaine Bertrand , Soueidan Sara E. , MacLeod Katrina M.
Published: October 2019

Single neurons function along a spectrum of neuronal operating modes whose properties determine how the output firing activity is generated from synaptic input. The auditory brain stem contains a diversity of neurons, from pure coincidence detectors to pure integrators and those with intermediate properties. We investigated how intrinsic spike initiation mechanisms regulate neuronal operating mode in the avian cochlear nucleus. Although the neurons in one division of the avian cochlear nucleus, nucleus magnocellularis, have been studied in depth, the spike threshold dynamics of the tonically firing neurons of a second division of cochlear nucleus, nucleus angularis (NA), remained unexplained. The input-output functions of tonically firing NA neurons were interrogated with directly injected in vivo-like current stimuli during whole cell patch-clamp recordings in vitro. Increasing the amplitude of the noise fluctuations in the current stimulus enhanced the firing rates in one subset of tonically firing neurons (“differentiators”) but not another (“integrators”). We found that spike thresholds showed significantly greater adaptation and variability in the differentiator neurons. A leaky integrate-and-fire neuronal model with an adaptive spike initiation process derived from sodium channel dynamics was fit to the firing responses and could recapitulate >80% of the precise temporal firing across a range of fluctuation and mean current levels. Greater threshold adaptation explained the frequency-current curve changes due to a hyperpolarized shift in the effective adaptation voltage range and longer-lasting threshold adaptation in differentiators. The fine-tuning of the intrinsic properties of different NA neurons suggests they may have specialized roles in spectrotemporal processing.

NEW & NOTEWORTHY Avian cochlear nucleus angularis (NA) neurons are responsible for encoding sound intensity for sound localization and spectrotemporal processing. An adaptive spike threshold mechanism fine-tunes a subset of repetitive-spiking neurons in NA to confer coincidence detector-like properties. A model based on sodium channel inactivation properties reproduced the activity via a hyperpolarized shift in adaptation conferring fluctuation sensitivity.
Ventilation/Perfusion Matching: Of Myths, Mice, and Men
Authors: Clark Alys R. , Burrowes Kelly S. , Tawhai Merryn H.
Published: October 2019

Despite a huge range in lung size between species, there is little measured difference in the ability of the lung to provide a well-matched air flow (ventilation) to blood flow (perfusion) at the gas exchange tissue. Here, we consider the remarkable similarities in ventilation/perfusion matching between species through a biophysical lens and consider evidence that matching in large animals is dominated by gravity but in small animals by structure.
A Case of Myeloid Sarcoma following Allogeneic HSCT Presenting as Localized Hip Pain
Authors: Zhang Shannon , Charlton Casey , Amaraneni Akshay , Maher Keri
Published: October 2019

Myeloid sarcoma is a rare variant of acute myeloid leukemia (AML) which presents as an extramedullary soft tissue mass. Due to the rarity of this disease, along with nonspecific presenting symptoms, diagnosis can be delayed or missed without a high index of suspicion. In this case, we discuss a patient diagnosed with AML relapse in the form of myeloid sarcoma two years after allogeneic hematopoietic stem cell transplant (alloHSCT) for myelodysplastic syndrome (MDS) with the initial presentation for back pain misdiagnosed as spinal stenosis. This case report aims to help healthcare providers in recognizing the early signs and symptoms of this disorder as well as provide information in regards to treatment options and risk assessment.
Leiomyosarcoma after Total Laparoscopic Hysterectomy with Power Morcellation
Authors: Takahashi Tsukasa , Ugajin Tomohisa , Imai Noriaki , Hayasaka Atsushi , Yaegashi Nobuo , Otsuki Takeo
Published: October 2019

Introduction. Power morcellation is an effective and minimally invasive technique used to remove specimen tissues or the uterus in total laparoscopic hysterectomy (TLH). However, it has the risk of intraperitoneal dissemination of tissue and can cause a parasitic myoma. We report a case of leiomyosarcoma that occurred 4 years after TLH with power morcellation for fibroids. Case. A 52-year-old woman was referred to our hospital with a pelvic mass. She was diagnosed to have submucosal fibroids and had undergone TLH with power morcellation 4 years previously. The uterus weighed 398 g at that time. At present, a parasitic myoma was suspected, owing to the diagnosis of fibroids on the initial pathological evaluation. She underwent laparotomy, and the tumor was removed. Although the pathological evaluation confirmed the tumor to be a leiomyosarcoma, a review of the initial tissue did not show the presence of any malignancy. Since there was no metastasis, she was followed-up without additional treatment. Conclusion. Even if the initial pathologic evaluation suggests a benign mass, parasitic myoma and even sarcoma can occur after TLH with power morcellation. Considering the risk of dissemination and occult malignancy, the use of power morcellation should be avoided if there are alternative options to remove the tumor.
Considering Passenger Preferences in Integrated Postdisruption Recoveries of Aircraft and Passengers
Authors: Yang Tianshun , Hu Yuzhen
Published: October 2019

After a disruption to its operations, an airline needs to dispatch its aircraft and accommodate affected passengers in order to resume normal operations. When facing a flight delay or cancelation, passengers usually have two options—switching to a different itinerary or receiving ticket refunds. This paper focuses on the integrated recovery of both aircraft and passengers by taking into consideration passengers’ preferences regarding the two options. Objectives include minimizing the financial loss of airlines and minimizing the utility loss of passengers. To solve the optimization problem, we present a loop‐based multiobjective genetic algorithm (GA) by leveraging a special characteristic of flight networks. Experiments based on real‐world data demonstrate the effectiveness and stability of the algorithm in various situations. The outcome has theoretical and practical implications for disruption management and airline operations.
Polyunsaturated Fatty Acids from Astrocytes Activate PPARγ Signaling in Cancer Cells to Promote Brain Metastasis
Authors: Zou Yongkang , Watters Andrea , Cheng Nan , Perry Caroline E. , Xu Ke , Alicea Gretchen M. , Parris Joshua L.D. , Baraban Ezra , Ray Pulak , Nayak Anupma , Xu Xiaowei , Herlyn Meenhard , Murphy Maureen E. , Weeraratna Ashani T. , Schug Zachary T. , Chen Qing
Published: October 2019

Brain metastasis, the most lethal form of melanoma and carcinoma, is the consequence of favorable interactions between the invading cancer cells and the brain cells. Peroxisome proliferator–activated receptor γ (PPARγ) has ambiguous functions in cancer development, and its relevance in advanced brain metastasis remains unclear. Here, we demonstrate that astrocytes, the unique brain glial cells, activate PPARγ in brain metastatic cancer cells. PPARγ activation enhances cell proliferation and metastatic outgrowth in the brain. Mechanistically, astrocytes have a high content of polyunsaturated fatty acids that act as “donors” of PPARγ activators to the invading cancer cells. In clinical samples, PPARγ signaling is significantly higher in brain metastatic lesions. Notably, systemic administration of PPARγ antagonists significantly reduces brain metastatic burden in vivo. Our study clarifies a prometastatic role for PPARγ signaling in cancer metastasis in the lipid-rich brain microenvironment and argues for the use of PPARγ blockade to treat brain metastasis.

Significance:

Brain-tropic cancer cells take advantage of the lipid-rich brain microenvironment to facilitate their proliferation by activating PPARγ signaling. This protumor effect of PPARγ in advanced brain metastases is in contrast to its antitumor function in carcinogenesis and early metastatic steps, indicating that PPARγ has diverse functions at different stages of cancer development.

This article is highlighted in the In This Issue feature, p. 1631
Assessment of Capacity Impairment in Patients with Mental Disorders by Routine Clinical Assessment and by Structured Assessment with the Mini-ICF-APP
Authors: Muschalla Beate , Poguntke Kim Joy , Linden Michael
Published: October 2019

Background: Physicians and therapists are also consulted to give judgments on working ability. Ability to work cannot simply be derived from the patient’s symptom status but from the illness-related capacity impairments in relation to the work demands. A structured assessment of capacity impairments has been evaluated and applied internationally: the Mini-ICF-APP Social Functioning Scale. It is currently unclear whether a free-text clinical report (i.e., usual clinical practice: clinical exploration according to clinical standards, but without a standardized documentation form, instead a text is written) and a structured capacity assessment correspond to the overall work ability judgment, i.e., the decision whether a patient is “fit for work” or “unfit for work.” Objectives: This investigation assessed, for the first time, whether usual clinical judgment and the additional structured capacity rating support the work ability decision. Methods: A total of 100 medical reports from patients in a psychotherapy hospital were excerpted for psychopathological symptoms and capacity disorders using a checklist. Additionally, a structured assessment of capacity disorders was documented on the Mini-ICF-APP rating for all patients. Results: In the free-text clinical medical report, endurance, flexibility, and contacts to others were the things mainly reported as impaired. This was similar to the structured Mini-ICF-APP rating. However, other capacity impairments were also reported in the Mini-ICF-APP, i.e., adherence to rules and regulations, planning and structuring, assertiveness, and group integration. When the free-text clinical report and the structured Mini-ICF-APP rating were compared, there was a higher rate of stated impairments covering all capacity dimensions in the Mini-ICF-APP rating. Conclusions: The free-text report in the medical report shows the differences between patients who are fit for work and those who are not, and thus speak for the validity of work ability decisions. However, optimization is possible in terms of depth and differentiation of capacity impairment description by adhering to the standard set by the Mini-ICF-APP.
Real-World Outcomes of Rivaroxaban Treatment in Patients with Both Nonvalvular Atrial Fibrillation and a History of Ischemic Stroke/Transient Ischemic Attack
Authors: Minematsu Kazuo , Ikeda Takanori , Ogawa Satoshi , Kitazono Takanari , Nakagawara Jyoji , Miyamoto Susumu , Murakawa Yuji , Takeichi Makiko , Kidani Yoko , Okayama Yutaka , Sunaya Toshiyuki , Sato Shoichiro , Yamanaka Satoshi
Published: October 2019

Introduction: Prior stroke is a risk factor for stroke and bleeding during anticoagulation in patients with atrial fibrillation (AF). Although rivaroxaban is widely prescribed to reduce their risk of stroke in patients with nonvalvular AF (NVAF), the real-world evidence on rivaroxaban treatment is limited. We aimed to examine the outcomes of rivaroxaban treatment in NVAF patients with prior ischemic stroke/transient ischemic attack (TIA) by using the data of the Xarelto Post-Authorization Safety and Effectiveness Study in Japanese ­Patients with AF, a prospective, single-arm, observational study. Methods: The clinical outcomes of 9,578 patients who completed the 1-year follow-up were evaluated. Safety and effectiveness outcomes were compared between patients with and without prior ischemic stroke/TIA. Results: Among the patients, 2,153 (22.5%) had prior ischemic stroke/TIA. They were significantly older and had lower body weight, lower creatinine clearance, higher CHADS2, CHA2DS2-VASc, and modified HAS-BLED scores as compared to those without prior ischemic stroke/TIA. Any bleeding (9.1 vs. 7.2 events per 100 patient-years), major bleeding (2.3 vs. 1.6 events per 100 patient-years), and stroke/non-central nervous system systemic embolism/myocardial infarction (3.4 vs. 1.3 events per 100 patient-years) were more frequent in patients with prior ischemic stroke/TIA. Stepwise regression analysis suggested that body weight of ≤50 kg and diabetes mellitus were predictive of major bleeding in patients with prior ischemic stroke/TIA. Conclusions: Safety and effectiveness event rates were higher in patients with prior ischemic stroke/TIA than those without. This might be explained by differences in several risk profiles including age, body weight, renal function, and risk scores such as CHADS2 between the groups. Clinicaltrials.gov: NCT01582737.
Validation of the ILD-GAP Model and a Local Nomogram in a Singaporean Cohort
Authors: Kam Michelle L.W. , Li Hui Hua , Tan Yi Hern , Low Su Ying
Published: October 2019

Background: The ILD-GAP model was developed and validated in a Western cohort to predict 1-, 2- and 3-year mortality in chronic interstitial lung disease (ILD). Objectives: We aimed to validate the ILD-GAP model and identify predictors of mortality to derive a nomogram to predict mortality in our local Asian population. Methods: Characteristics of patients on follow-up in a tertiary ILD referral center were retrospectively reviewed. Results: There were 181 patients and 48 mortalities. 29.8% had idiopathic pulmonary fibrosis, 2.8% unclassifiable ILD, 33.1% connective tissue disease-associated interstitial lung disease (CTD-ILD), 28.7% idiopathic nonspecific interstitial pneumonia and 5.5% chronic hypersensitivity pneumonitis. Univariable analysis showed that a higher ILD-GAP index, unclassified ILD, males, older age, higher pulmonary artery systolic pressure, lower forced vital capacity percent predicted and carbon monoxide diffusion capacity (DLCO) correlated with increased mortality, and CTD had lower mortality. Multivariable analysis utilizing Akaike’s information criterion stopping rule showed males and a lower DLCO predicted increased mortality, while CTD predicted lower mortality. These were used to generate a nomogram which predicted overall mortality better (C index 0.817, adequacy index 99.5%) than ILD-GAP (C index 0.777, adequacy index 60.7%) and provided superior estimates based on likelihood ratio testing. Calibration plots showed the nomogram predicted 1-year mortality better, whilst the ILD-GAP model predicted 2- and 3-year mortality closer to actual mortality rates but underpredicted 1-year mortality. Conclusion: The nomogram performed better than ILD-GAP in predicting overall mortality and 1-year mortality. Both demonstrated good performance in predicting mortality risk.
Antiallodynic Effect of Intrathecal Korean Red Ginseng in Cisplatin-Induced Neuropathic Pain Rats
Authors: Kim Yeo Ok , Song Ji A , Kim Woong Mo , Yoon Myung Ha
Published: October 2019

Background: Chemotherapy-induced neuropathic pain (CINP) is a serious side effect of chemotherapy. Korean Red Ginseng (KRG) is a popular herbal medicine in Asian countries. We examined the therapeutic potential of intrathecally administered KRG for CINP and clarified the mechanisms of action with regard to 5-hydroxytryptamine (5-HT)7 receptor at the spinal level. Methods: CINP was evoked by intraperitoneal injection of cisplatin in male Sprague-Dawley rats. After examining the effects of intrathecally administered KRG on CINP, 5-HT receptor antagonist (dihydroergocristine [DHE]) was pretreated to determine the involvement of 5-HT receptor. In addition, intrathecal 5-HT7 receptor antagonist (SB269970) was administered to define the role of 5-HT7 receptor on the effect of KRG. 5-HT7 receptor mRNA expression levels and 5-HT concentrations were examined in the spinal cord. Results: Intrathecally administered KRG produced a limited, but a dose-dependent, antiallodynic effect. Intrathecally administered DHE antagonized the antiallodynia caused by KRG. Furthermore, intrathecal SB269970 also reversed the effect of KRG. No changes in 5-HT7 receptor mRNA expression were seen in the dorsal horn of the spinal cord after cisplatin injection. After injecting cisplatin, 5-HT levels were decreased in the spinal cord, whereas those of 5-HT were increased by intrathecal KRG. Conclusions: Intrathecally administered KRG decreased CINP. In addition, spinal 5-HT7 receptors contributed to the antiallodynic effect of KRG.
Erythema Gyratum Repens in Long-Term Smoker
Authors: Sauvageau Andrew P. , Mojeski Jacob , Fiorica Thomas W. , Miller Craig C.
Published: October 2019

Erythema gyratum repens (EGR) is a rare paraneoplastic skin condition characterized by the eruption of expanding, concentric, erythematous patches and plaques. The condition may precede a symptomatic appearance of internal malignancy, and therefore provides a unique opportunity to prevent additional morbidity and mortality secondary to undetectable cancer growth. We report the case of a 71-year-old female patient clinically diagnosed with EGR and subsequently diagnosed with otherwise asymptomatic adenocarcinoma of the lung.
Nanoparticle Albumin-Bound Paclitaxel- and/or Gemcitabine-Induced Scleroderma Accompanied by Acanthosis Nigricans-Like Skin Changes
Authors: Motegi Sei-ichiro , Ishikawa Mai , Sekiguchi Akiko , Ishikawa Osamu
Published: October 2019

We herein present the first case of nanoparticle albumin-bound paclitaxel (nab-paclitaxel)- and/or gemcitabine-induced scleroderma accompanied by acanthosis nigricans-like skin changes in a 54-year-old Japanese male. He was diagnosed with pancreatic cancer and received 17 courses of nab-paclitaxel and gemcitabine chemotherapy. Edema and skin sclerosis in his legs appeared after the first and third course, respectively. Histological examination of the hyperkeratotic lesion of the ankle revealed hyperkeratosis, acanthosis, papillomatosis, increased number of melanocytes in the basal layer, and dermal fibrosis. Awareness of the clinical characteristics of nab-paclitaxel- and/or gemcitabine-induced scleroderma accompanied by acanthosis nigricans-like skin changes is important for dermatologists to establish an accurate diagnosis.
Gastric Electrical Stimulation Is an Effective Treatment Modality for Refractory Gastroparesis in a Postsurgical Patient with Pancreatic Cancer
Authors: Doshi Shreyans , Patel Aniruddh , Stocker Abigail , Scoggins Charles , Agrawal Laila , Abell Thomas
Published: October 2019

Gastroparesis-related hospital visits contribute significantly to healthcare costs. Gastroparesis can lead to chronic symptoms, such as nausea, vomiting, bloating, early satiety, and abdominal pain. It can result in a significant impairment of quality of life. Diabetes and postsurgery are common causes for gastroparesis, but most cases of gastroparesis are idiopathic in presumed etiology. Malignancy-related gastroparesis has also recently been described in the literature, and pancreatic cancer is a malignancy commonly associated with gastroparesis. Whipple surgery for pancreatic cancer is often complicated by gastroparesis during its postoperative course. We report a case where gastric electrical stimulation was an effective treatment option in the treatment of refractory malignancy-related gastroparesis.
Representation of Arabic and Syriac in the Samaritan Version of Saadya Gaon’s Translation of the Pentateuch
Authors: Zewi Tamar
Published: October 2019

Saadya ben Joseph al-Fayyumi (Saˁīd b. Yūsuf al-Fayyūmī, Saadya Gaon, b. Egypt 882—d. Baghdad 942) translated the Pentateuch as well as several other parts of the Bible into Arabic in the first half of the 10th century. The translation, named tafsīr by Saadya himself, was transmitted in two versions, one in Hebrew letters, probably intended for and used by Jewish-Rabbanite communities, and another in Arabic letters, probably intended for and used by other communities. Several manuscripts holding a Saadyan version in Arabic letters were used by Christian communities in the Near East. Some of these manuscripts probably reached the Samaritans, or at least one Samaritan community. The main source consisting of the Samaritan version of Saadya Gaon’s translation of the Pentateuch is MS London BL OR 7562. The article discusses the status of this manuscript among the other Samaritan Arabic translations, its characteristics, and demonstrates the reflections of Arabic and Syriac vocabulary in its Samaritan script.
Notes on typification and nomenclature of four taxa of Geraniaceae described by Turczaninow from New Zealand and Australia

Authors: MOSYAKIN SERGEI L. , DE LANGE PETER J.
Published: October 2019

Issues of the nomenclature and typification of four species of Geraniaceae described by Turczaninow from Australia and New Zealand are discussed. It is emphasized that holotypes or syntypes of all taxa described by Turczaninow in his Animadversiones series of articles are deposited in the Turczaninow historical herbarium at KW, unless noted otherwise in the protologue. Lectotypes are designated here for the names Geranium homeanum Turcz. (KW, second-step lectotypification), Erodium peristeroides Turcz. (KW), Pelargonium stenanthum Turcz. (K, to replace the lost holotype formerly held in KW), and P. inodorum Willd. (B, second-step lectotypification). Taxonomic identities of some names are discussed: Geranium homeanum and Pelargonium drummondii Turcz. (holotype in KW) are currently accepted species, Erodium peristeroides is considered a synonym of Pelargonium inodorum, and P. stenanthum is a synonym of P. littorale Huegel.
Aristida surperuanensis (Poaceae, Aristidoideae), a new species from a desert valley in southern Peru

Authors: GUTIÉRREZ HAROL , CASTAÑEDA ROXANA , QUIPUSCOA VICTOR , PETERSON PAUL M.
Published: October 2019

Aristida surperuanensis sp. nov. is described and illustrated. The new species, from southern Moquegua (Peru), differs from A. flaccida in having contracted panicles, spikelets to 1–1.1 cm long and lemmas 5.5–6.5 mm long. The central awn is straight, ascending, 3–6 mm long and lacking a column, the lateral awns are ascending, 1–2.5 mm long and 1/3 as long as the central awns, and the caryopses are fusiform and 4–4.5 (–6) mm long. A key to the species of Aristida in Peru is included and the conservation status of the new species is evaluated.
Martensia incipiens (Delesseriaceae, Rhodophyta), a newly recognized species of red algae from the Sultanate of Oman

Authors: WYNNE MICHAEL J.
Published: October 2019

Martensia incipiens sp. nov. is described from the Sultanate of Oman, based upon collections made in the Governate of Dhofar, Northern Arabian Sea. The type locality is Sadah. The delicate blades display a dazzling iridescence with pink to lilac colors in the living condition. The distinguishing morphological feature of this novel species is that the latticework is confined to a very narrow marginal fringe, consisting of vertical files of only six to nine cells in length and without any cross-links between the vertical files. Putative young tetrasporangial sori have a scattered arrangement over the blades.
Mariticide in Milan between 1990 and 2017: A criminological and medico-legal analysis
Authors: Merzagora Isabella , Battistini Alessio , Caruso Palmina , Mottale Nicole , Pleuteri Lorenza , Travaini Guido
Published: October 2019

Most murder victims in a romantic relationship are women but sometimes they will kill their husbands or partners (mariticide). This paper focuses on these rarer cases using a sample taken from the autopsy reports of the Department of Legal Medicine of the University of Milan whose territory includes the municipality of Milan and part of the province of Milan and Monza – approximately four million inhabitants.
A method to produce ring single yarn with fancy and anti-frictional structure by feeding filaments in front of the front roller nip
Authors: Xia Zhigang , Wang Hong Shan , Ye Wenxiang
Published: October 2019

In this study, a composite ring spinning via feeding filaments in front of the front roller nip method was developed as a novel, effective way to form yarn surface looped fancy wrappings. The novel method was theoretically demonstrated to produce fil-wrap yarn with tight filament wrappings and periodic filament loop decorations on the surface. Tight filament wrappings fasten staple fibers firmly onto the yarn stem to achieve excellent anti-friction, while filament loops decorate the yarn surface to yield a fancy appearance. However, intensive bending of looped and wrapping filaments are likely sheared down to decrease the yarn’s tensile strength. The novel method was combined with corefil spinning to produce a fil-clamp yarn with enhanced structural fastness and strength. Experiments were conducted to validate the approach. Experimental results proved that the novel fil-wrap and fil-clamp yarns had periodic filament looped and tight wrappings, resulting in eliminated hairiness and increased fancy loops after comparison with conventional sirofil and corefil yarns. respectively. The fil-wrap yarn with only surface-bending filament wrappings was weaker, but more friction-resistant than conventional sirofil and corefil yarns. Yarn strength and anti-friction were enhanced after burying straight filaments in the fil-wrap yarn body to form a fil-clamp yarn. The fil-clamp yarn with fancy and anti-frictional structure is expected to endow fabrics with improved fluffiness, softness and anti-frictional properties.
Glitchy vignettes of platform urbanism
Authors: Leszczynski Agnieszka
Published: October 2019

‘Platform urbanism’ has recently gained traction as a designator for emergent dynamics and material configurations associated with the increasing presence of digital platform enterprises in cities. Initial scholarly engagements with platform urbanism have tended to coalesce around critiques of digital platforms as progenitors of inevitably dystopian urban futures. In this paper, I advance a counter-topographical minor theory of platform urbanism. I do so by drawing on Legacy Russell's notion of the glitch as a tendency toward both error and erratum (correction) in digital systems, mobilizing space/times where platforms appear ‘glitchy’—unexpectedly, otherwise than anticipated, or not at all—as the margins of platform urbanism. Through the narration of three specific platform/city interfaces from the minors of their glitchy margins, I capture the ways in which platform–urban configurations are demonstrably open to negotiations, reconfigurations, and diffractions through tactical maneuvers rooted in everyday digital practices of urban denizens. Theorized from the minor, platform urbanism is a phenomenon that may beget an array of possible outcomes that remain shapeable by mundane tactical interventions in the platform-mediated present. This ultimately underwrites possibilities for more hopeful digital urban politics, theory, and futures.
Altered brain structural and cognitive impairment in end-stage renal disease patients with secondary hyperparathyroidism
Authors: Gong Xijun , Zou Liwei , Wu Hanqiu , Shan Yanqi , Liu Guiling , Zheng Suisheng , Wang Longsheng
Published: October 2019

Background

Cognitive impairment has received attention as an important problem in patients with end-stage renal disease, although end-stage renal disease patients with secondary hyperparathyroidism have not been studied.

Purpose

To assess the pattern of brain volume changes in end-stage renal disease patients with secondary hyperparathyroidism by using voxel-based morphometry and correlating these measures with clinical markers and the Montreal Cognitive Assessment scores.

Material and Methods

Fifty end-stage renal disease patients with no anatomical abnormalities in conventional MRI (25 patients with secondary hyperparathyroidism, 14 men, mean age 42.20 ± 7.53 years; 25 patients without secondary hyperparathyroidism, 15 men, mean age 41.96 ± 6.17 years) were selected in this study. All patients underwent laboratory tests, neuropsychological tests, and MRI. Voxel-based morphometry analysis was performed to detect regional gray matter volume differences between the two groups. The relationships between abnormal gray matter volume and clinical markers and Montreal Cognitive Assessment scores were investigated.

Results

Voxel-based morphometry revealed increased gray matter volume in end-stage renal disease patients with secondary hyperparathyroidism in the bilateral caudate and bilateral thalamus compared with non- secondary hyperparathyroidism end-stage renal disease patients ( P < 0.05, FWE corrected). Regarding the laboratory and neuropsychological tests, we found significant correlations between volume in these brain regions and intact parathyroid hormone levels and negative correlations with the Montreal Cognitive Assessment scores. There were no significant associations between brain volume changes and other clinical data (disease duration, urea, creatinine, and uric acid levels).

Conclusion

Our results showed significantly increased gray matter volume in end-stage renal disease patients with secondary hyperparathyroidism, which was associated with intact parathyroid hormone levels and cognitive impairment. Serum intact parathyroid hormone levels may be a risk factor for cognitive impairment in end-stage renal disease patients with secondary hyperparathyroidism.
Efficient solar radiation estimation using cohesive artificial neural network technique with optimal synaptic weights
Authors: Kumar S , Kaur T
Published: October 2019

Estimation of solar potential is vital for renewable energy applications. In several studies, artificial neural networks have been employed to model solar radiation using various meteorological parameters. The collection and availability of the most appropriate input parameters is important for getting an accurate artificial neural network model. The present study aims to estimate the global solar radiation using different meteorological parameters and identify the significant parameters based on the analysis of synaptic weights in an artificial neural network model using the connection weight approach. Initially, artificial neural network and empirical models is applied to estimate the solar radiation in Chamba region. The artificial neural network architecture 5-48-15-1 resulted in minimum mean absolute percentage error of 12.15%. The mean absolute percentage error values for linear models are found to be 18.95%, 15.39%, and 21.62%, respectively. Thereafter, connection weight approach is applied to find significant parameters. The efficacy of the approach has been shown through a case study related to estimation of solar radiations in the Hamirpur region situated in the state of Himachal Pradesh (India). Five input parameters, namely temperature (T), relative humidity (RH), clearness index (KT), precipitation (PT), and pressure (P), have been considered to estimate solar radiations using a feed-forward neural network. The proposed approach infers that temperature is the most significant parameter followed by humidity and pressure. The clearness index and precipitation has been found to have the least effect on the estimation of solar radiations. Results also indicate that artificial neural network based technique is more accurate compared to empirical model.
The prevalence of distress, depression, anxiety, and substance use issues among Indigenous post-secondary students in Canada
Authors: Hop Wo Nolan K , Anderson Kelly K , Wylie Lloy , MacDougall Arlene
Published: October 2019

This study aimed to estimate the prevalence of mental illness and substance use among Indigenous students attending Canadian post-secondary institutions. We obtained data from the National College Health Assessment - American College Health Association Spring 2013 survey, which includes 34,039 participants in 32 post-secondary institutions across Canada. We calculated prevalence estimates with 95% confidence intervals (CI). We compared Indigenous and non-Indigenous students using age- and sex-adjusted prevalence ratios (PR) obtained from Poisson regression models. Of the total sample, 1,110 (3.3%) post-secondary students self-identified as Indigenous. Within the past 12 months, Indigenous students had higher odds of intentionally injuring themselves (PR = 1.53, 95% CI = 1.27–1.84), seriously considering suicide (PR = 1.32, 95% CI = 1.12–1.56), attempting suicide (PR = 1.74, 95% CI = 1.16–2.62), or having been diagnosed with depression (PR = 1.26, 95% CI = 1.08–1.47) or anxiety (PR = 1.18, 95% CI = 1.02–1.35) when compared with non-Indigenous students. Indigenous students also had higher odds of having a lifetime diagnosis of depression (PR = 1.31, 95% CI = 1.17–1.47) when compared with non-Indigenous students. Indigenous students were more likely to report binging on alcohol (PR = 1.10, 95% CI = 1.02–1.19), using marijuana (PR = 1.21, 95% CI = 1.06–1.37), and using other recreational drugs (PR = 1.32, 95% CI = 1.06–1.63) compared to non-Indigenous students. This study demonstrates that Indigenous students at post-secondary institutions across Canada experience higher prevalence of mental health and related issues compared to the non-Indigenous student population. This information highlights the need to assess the utilization and ensure the appropriate provision of mental health and wellness resources to support Indigenous students attending post-secondary institutions.
Vibration characteristic analysis of spur gear systems under tooth crack or fracture
Authors: Li Xu , Chen Kangkang , Huangfu Yifan , Ma Hui , Zhao Baishun , Yu Kun
Published: October 2019

Tooth fractures and cracks are common defects in gear transmission systems. Crack propagation paths of the spur gears are acquired using the fracture mechanics theory. Based on the simulated crack propagation path, the flexible body model of the cracked gear system is established in multibody dynamic software ADAMS. The vibration signals of cracked gear under different torques obtained from the simulation are verified by the experimental results. Some statistical indictors (root mean square and Kurtosis) are used to quantify the damage degree. In addition, the fault features of the gear system under crack and tooth fracture faults are analyzed by utilizing the instantaneous energy. The results indicate that the amplitude of the harmonics of the meshing frequency and the sideband frequencies increase gradually with the increase of torques and crack lengths. Especially, for the tooth fracture fault, its influence on Kurtosis value is particularly obvious. Meanwhile, according to the instantaneous energy, the tooth fracture fault will result in severe energy impacts and cause a sharp increase in the vibration amplitude.
Development of simultaneous determination of empagliflozin and metformin in human plasma using liquid chromatography–mass spectrometry and application to pharmacokinetics
Authors: Wattamwar Tejas , Mungantiwar Ashish , Halde Supriya , Pandita Nancy
Published: October 2019

A rapid and sensitive liquid chromatography–mass spectrometry method was developed, optimized, and validated for simultaneous quantification of empagliflozin and metformin in human plasma using empagliflozin D4and metformin D6 as an internal standard. Analytes and internal standard were extracted from plasma by optimized solid-phase extraction technique using Strata X polymeric reverse phase (30 mg-1cc) solid-phase extraction cartridges. The prepared samples were chromatographed on Orosil C18 column (150 × 4.6 mm, 3 µ). Separation was done by pumping isocratic mobile phase consisting of methanol and 10 mM ammonium trifluoroacetate (90:10, v/v) in positive ion mode at a flow rate of 0.8 mL/min. The API 3200 liquid chromatography–mass spectrometry system having turbo ion spray as an ion source coupled with Shimadzu Prominence ultrafast liquid chromatography system was operated under the selected reaction monitoring mode. Turbo ion spray ionization was used for mass transition of m/z 468.070/355.100 and m/z 130.072/71.200 for empagliflozin and metformin, respectively. A method was successfully validated for concentration range of 10.09–5013.46 ng/mL for both the analytes and according to the United States Food and Drugs Administration guidelines. The linearity was found to be in the range of 10.09–403.46 ng/mL for empagliflozin and 25.44–5013.46 ng/mL for metformin. The limit of quantification was found to be 10.09 ng/mL for empagliflozin and 25.44 ng/mL for metformin. Intra- and inter-day/between batch precision determination for empagliflozin and metformin, expressed as coefficient of variation were within the acceptance limits and ranged below 13.16%. A short run time of 3.3 min allows analysis of more than 400 plasma samples per day. The developed method was successfully applied to fasting pharmacokinetic study in healthy human volunteers. Results of incurred sample re-analysis were within the acceptance range of ±20% of original value, for 97.2% of samples reanalyzed for empagliflozin and 100% of samples reanalyzed for metformin.
Role of E2Fs and mitotic regulators controlled by E2Fs in the epithelial to mesenchymal transition
Authors: Jusino Shirley , Saavedra Harold I
Published: October 2019

The epithelial-to-mesenchymal transition (EMT) is a complex cellular process in which epithelial cells acquire mesenchymal properties. EMT occurs in three biological settings: development, wound healing and fibrosis, and tumor progression. Despite occurring in three independent biological settings, EMT signaling shares some molecular mechanisms that allow epithelial cells to de-differentiate and acquire mesenchymal characteristics that confer cells invasive and migratory capacity to distant sites. Here we summarize the molecular mechanism that delineates EMT and we will focus on the role of E2 promoter binding factors (E2Fs) in EMT during tumor progression. Since the E2Fs are presently undruggable due to their control in numerous pivotal cellular functions and due to the lack of selectivity against individual E2Fs, we will also discuss the role of three mitotic regulators and/or mitotic kinases controlled by the E2Fs (NEK2, Mps1/TTK, and SGO1) in EMT that can be useful as drug targets.

Impact statement

The study of the epithelial to mesenchymal transition (EMT) is an active area of research since it is one of the early intermediates to invasion and metastasis—a state of the cancer cells that ultimately kills many cancer patients. We will present in this review that besides their canonical roles as regulators of proliferation, unregulated expression of the E2F transcription factors may contribute to cancer initiation and progression to metastasis by signaling centrosome amplification, chromosome instability, and EMT. Since our discovery that the E2F activators control centrosome amplification and mitosis in cancer cells, we have identified centrosome and mitotic regulators that may represent actionable targets against EMT and metastasis in cancer cells. This is impactful to all of the cancer patients in which the Cdk/Rb/E2F pathway is deregulated, which has been estimated to be most cancer patients with solid tumors.
Effects of auditory-motor synchronization on 400-m sprint performance: An applied study
Authors: Karageorghis Costas I , Hutchinson Jasmin C , Bigliassi Marcelo , Watson Michael PE , Perry Francis A , Burges Lewis D , Melville-Griffiths Troy , Gomes-Baho Tristan JG
Published: October 2019

There is a conspicuous dearth of empirical research regarding the ergogenic and psychological effects of synchronous music when applied in a sports training context. The main purpose of this longitudinal intervention study was to investigate the ergogenic and psychological effects of synchronous music applied over a one-month period of speed endurance training. Twelve participants (six women and six men; 21.1 ± 1.7 years) were randomly assigned to either an experimental group (sprint training coordinated with synchronous music) or a control group (conventional sprint training). Immediately after each training session and each time trial, the Feeling Scale, CR-10 Rating of Perceived Exertion Scale, and Physical Activity Enjoyment Scale were administered to each participant. No significant interaction effect of Group × Time for Rating of Perceived Exertion ( p = .898) or Physical Activity Enjoyment Scale ( p = .411) was identified during the training sessions. A significant Group × Time interaction was identified for Feeling Scale scores ( p = .007). Nonetheless, following Bonferroni adjustment for pairwise comparisons, the between-group differences in Feeling Scale scores did not reach significance. No significant interaction effect of Group × Time or main effect of group was identified for sprint performance, although the latter effect was associated with a large effect size (ηp2 = 0.35). Experimental group participants executed the 400-m time trials 5.07% faster than control group participants. This finding is noteworthy from an applied perspective, given the potential ergogenic effects associated with auditory-motor synchronization.
Cognitive behavioural therapy significantly reduces anxiety in patients with implanted cardioverter defibrillator compared with usual care: Findings from the Screen-ICD randomised controlled trial
Authors: Berg Selina K , Rasmussen Trine B , Herning Margrethe , Svendsen Jesper H , Christensen Anne V , Thygesen Lau C
Published: October 2019

Aim

The aim of this study was to investigate the effect of a cognitive behavioural therapy intervention provided by trained cardiac nurses plus usual care compared with usual care alone in patients with an implanted cardioverter defibrillator who, prior to randomization, had presented with symptoms of anxiety measured by the Hospital Anxiety and Depression Scale.

Background

Around 20–25% of all patients with an implanted cardioverter defibrillator experience anxiety. Among these patients anxiety is associated with mortality, presumably explained by risk behaviour and activation of the autonomic nervous system. We hypothesised that cognitive behavioural therapy provided by cardiac nurses in an out-patient setting would be an effective treatment of anxiety.

Methods

This was an investigator-initiated randomised clinical superiority trial with blinded outcome assessment, with 1:1 randomisation to cognitive behavioural therapy plus usual care or to usual care. The primary outcome was Hospital Anxiety and Depression Scale-Anxiety mean score at 16 weeks. Secondary outcomes included Hospital Anxiety and Depression Scale-Depression, Becks Anxiety Inventory, HeartQoL and Hamilton Anxiety Scale. Primary outcome analysis was based on the intention-to-treat principle.

Results

A total of 88 participants were included, 66% men, mean age 64.3 years and 61% had primary indication implantable cardioverter defibrillator. A significant difference after 16 weeks was found between groups: intervention group (Hospital Anxiety and Depression Scale-A mean (standard deviation) 4.95 points (3.30) versus usual care group 8.98 points (4.03) ( p < 0.0001)). Cohen's d was –0.86, indicating a strong clinical effect. The effect was supported by secondary outcomes.

Conclusion

Cognitive behavioural therapy provided by cardiac nurses to patients with a positive screening for anxiety had a statistically and clinically significant effect on anxiety compared with patients not receiving cognitive behavioural therapy.
Trusting Your Teacher: Implications for Policy
Authors: Corriveau Kathleen H. , Winters Marcus A.
Published: October 2019

Despite decades of research, predictors of teacher quality have been difficult to determine, leading to challenges in proposing policy. The current review suggests that students’ trust in teachers may be an important, but understudied, part of teacher success. Indeed, even young children are surprisingly adept at deciding what type of a teacher to choose to learn new information. First, they prefer to learn from a teacher who has been an accurate source of information in the past. But they also take into account various social features of the teacher such as familiarity, emotional relationship, and social group membership. This research on children’s trust in teachers can translate into practice and policies for improving student outcomes.
Integrating Social-Emotional and Academic Development in Teachers’ Approaches to Educating Students
Authors: Cross Francis Dionne , Liu Jinqing , Bharaj Pavneet Kaur , Eker Ayfer
Published: October 2019

Student success should incorporate not only academic achievement, but also the skills and competence to identify and effectively pursue personal life goals. However, success has become narrowly defined by test scores, which minimizes students’ opportunities for growth and development. Research findings show the interrelatedness of social, emotional, and cognitive dimensions of learning and how these dimensions shape positive student outcomes. In this article, we discuss how schools can integrate social, emotional, and academic development in optimizing student learning. Foregrounding teachers, the engines that drive the educational practices within schools, we describe their role in shaping student outcomes and identify the essential knowledge and skills needed to create academically and emotionally enriched spaces for students. We discuss the gaps in current teacher education and professional development (PD) programs that result in teachers being ill-prepared for the realities of the classroom. Finally, policy implications for teacher education, PD, and school reorganization are discussed.
Metabolome and transcriptome analyses reveal quality change in the orange-rooted Salvia miltiorrhiza (Danshen) from cultivated field
Authors: Zhan Zhilai , Fang Wentao , Ma Xiaohui , Chen Tong , Cui Guanghong , Ma Ying , Kang Liping , Nan Tiegui , Lin Huixin , Tang Jinfu , Zhang Yan , Lai Changjiangsheng , Ren Zhenli , Wang Yanan , Zhao Yujun , Shen Ye , Wang Ling , Zeng Wen , Guo Juan , Huang Luqi
Published: October 2019

Background

The dry root and rhizome of Salvia miltiorrhiza Bunge, or Danshen, is a well-known, traditional Chinese medicine. Tanshinones are active compounds that accumulate in the periderm, resulting in red-colored roots. However, lines with orange roots have been observed in cultivated fields. Here, we performed metabolome and transcriptome analyses to investigate the changes of orange-rooted Danshen.

Methods

Metabolome analysis was performed by ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC/Q-Tof–MS) to investigate the metabolites variation between orange Danshen and normal Danshen. RNA sequencing and KEGG enrichment analysis were performed to analyzing the differentially expressed genes between orange-rooted and normal Danshen.

Results

In total, 40 lipophilic components were detected in metabolome analysis, and seven compounds were significantly decreased in the orange Danshen, including the most abundant active compounds, tanshinone IIA and tanshinone I in normal Danshen. Systematic analysis of transcriptome profiles revealed that the down-regulated genes related to catalytic dehydrogenation was not detected. However, two genes related to stress resistance, and four genes related to endoplasmic reticulum (ER)-associated degradation of proteins were up-regulated in orange Danshen.

Conclusions

Decreases in the content of dehydrogenated furan ring tanshinones such as tanshinone IIA resulted in phenotypic changes and quality degradation of Danshen. Transcriptome analysis indicated that incorrect folding and ER-associated degradation of corresponding enzymes, which could catalyze C15-C16 dehydrogenase, might be contributed to the decrease in dehydrogenated furan ring tanshinones, rather than lower expression of the relative genes. This limited dehydrogenation of cryptotanshinone and dihydrotanshinone I into tanshinones IIA and I products, respectively, led to a reduced quality of Danshen in cultivated fields.