bluuebunny/crossref_metadata_2025 huggingface dataset:
The Geology of Eden Patera, a Type‐Example of Plains Style Caldera Complexes on Mars
Authors: Chu Yin Yau Yoyo , Michalski Joseph R. , Webb A. Alexander G.
Published: December 2022

A population of underrecognized volcanic constructs associated with explosive and effusive volcanism is present within Arabia Terra and perhaps throughout the ancient highlands on Mars. These features, termed “plains‐style caldera complexes,” are characterized by 10s‐of‐km wide crustal collapse structures, lava flows, and potential pyroclastic deposits, but without a pronounced central edifice. Vast layered deposits around Eden Patera and throughout Arabia Terra are possibly linked to these explosive volcanisms. Remote sensing‐based morphological and geologic mapping was carried out along with geomorphological and structural analyses, and the application of terrestrial analogs to test the hypothesis that these large‐scale collapse features are controlled by magmatism and volcanic activity. Here, we map the surface geology, structure, and geomorphology of Eden Patera, providing a well‐exposed and documented benchmark for the identification of other plains‐style caldera complexes across the surface of the Martian crust. The unexplored population of explosive process‐dominated volcanic constructs could potentially be an important yet underrecognized aspect of the Martian geologic record.
An Empirical Model of the Sporadic E Layer Intensity Based on COSMIC Radio Occultation Observations
Authors: Niu Jun , Fang Han‐xian
Published: December 2022

Ionospheric sporadic E layers are common phenomena occurring in the ionospheric E region altitude (∼90–120 km) with much higher electron density. The lack of a large amount of sporadic E layer intensity observation on a global scale restrains the construction of global modeling of sporadic E layer intensity. Recent studies reveal that radio occultation observation can be used for sporadic E layer intensity inversion. In this paper, a low‐mid latitude empirical model of sporadic E layer critical frequency is constructed based on Constellation Observing System for Meteorology, Ionosphere, and Climate radio occultation data during 2007–2012. Model results show good accordance with ionosonde observations over 16 stations in different latitudes. In general, the model has a good performance in simulating the climate variation features of sporadic E layer intensity with averaged deviation 0.23 MHz which indicates a slight overestimation. Besides, spatial and temporal variations simulated by the model are also analyzed and show good agreement with known sporadic E layer features. However, the empirical may be only suitable for climate research at present and potential methods to improve the model will be investigated in the latter research.
Data-driven methods for discovery of next-generation electrostrictive materials
Authors: Trujillo Dennis P. , Gurung Ashok , Yu Jiacheng , Nayak Sanjeev K. , Alpay S. Pamir , Janolin Pierre-Eymeric
Published: December 2022

All dielectrics exhibit electrostriction, i.e., display a quadratic strain response to an electric field compared to the linear strain dependence of piezoelectrics. As such, there is significant interest in discovering new electrostrictors with enhanced electrostrictive coefficients, especially as electrostrictors can exhibit effective piezoelectricity when a bias electric field is applied. We present the results of a study combining data mining and first-principles computations that indicate that there exists a group of iodides, bromides, and chlorides that have electrostrictive coefficients exceeding 10 m4 C–2 which are substantially higher than typical oxide electrostrictive ceramics and polymers. The corresponding effective piezoelectric voltage coefficients are three orders of magnitude larger than lead zirconate titanate.
Enhancing learning and retention with distinctive virtual reality environments and mental context reinstatement
Authors: Essoe Joey Ka-Yee , Reggente Nicco , Ohno Ai Aileen , Baek Younji Hera , Dell’Italia John , Rissman Jesse
Published: December 2022

Memory is inherently context-dependent: internal and environmental cues become bound to learnt information, and the later absence of these cues can impair recall. Here, we developed an approach to leverage context-dependence to optimise learning of challenging, interference-prone material. While navigating through desktop virtual reality (VR) contexts, participants learnt 80 foreign words in two phonetically similar languages. Those participants who learnt each language in its own unique context showed reduced interference and improved one-week retention (92%), relative to those who learnt the languages in the same context (76%)—however, this advantage was only apparent if participants subjectively experienced VR-based contexts as “real” environments. A follow-up fMRI experiment confirmed that reinstatement of brain activity patterns associated with the original encoding context during word retrieval was associated with improved recall performance. These findings establish that context-dependence can be harnessed with VR to optimise learning and showcase the important role of mental context reinstatement.
Differences in fish herbivory among tropical and temperate seaweeds and annual patterns in kelp consumption influence the tropicalisation of temperate reefs
Authors: Vergés Adriana , Lanham Brendan S. , Kono Madoka , Okumura Satoru , Nakamura Yohei
Published: December 2022

Climate change is leading to novel species interactions and profoundly altering ecosystems. In marine systems, tropical and subtropical species are increasing in higher latitudes. This has been linked to the deforestation of temperate coastlines, as direct effects of ocean warming combine with increased herbivory from tropical and sub-tropical fishes and lead to the decline of canopy-forming kelp. Here, we tested the hypothesis that this deforestation may be facilitated by greater palatability of temperate kelp and other canopy seaweeds compared to tropical taxa. We used multiple-choice filmed feeding field experiments and chemical analyses to measure the palatability of temperate and tropical seaweeds from Tosa Bay (southeastern Japan) and we used single-species feeding assays to measure changes in consumption of the kelp Ecklonia cava throughout the year. We found no evidence that temperate seaweeds are more palatable to herbivorous fish. In the multiple-choice assays, consumption was concentrated on both tropical and temperate Sargassum species, which are ephemeral and peak in abundance in the spring/early summer. Consumption of the kelp Ecklonia cava peaked during the autumn, when Sargassum species are absent. The highest levels of kelp herbivory coincide with the reproductive season for E. cava and may contribute to the long-term decline of these kelp forests in southern Japan.
A tensor decomposition-based integrated analysis applicable to multiple gene expression profiles without sample matching
Authors: Taguchi Y-h. , Turki Turki
Published: December 2022

The integrated analysis of multiple gene expression profiles previously measured in distinct studies is problematic since missing both sample matches and common labels prevent their integration in fully data-driven, unsupervised training. In this study, we propose a strategy to enable the integration of multiple gene expression profiles among multiple independent studies with neither labeling nor sample matching using tensor decomposition unsupervised feature extraction. We apply this strategy to Alzheimer’s disease (AD)-related gene expression profiles that lack precise correspondence among samples, including AD single-cell RNA sequence (scRNA-seq) data. We were able to select biologically reasonable genes using the integrated analysis. Overall, integrated gene expression profiles can function analogously to prior- and/or transfer-learning strategies in other machine-learning applications. For scRNA-seq, the proposed approach significantly reduces the required computational memory.
Transcriptomic changes underlying EGFR inhibitor resistance in human and mouse models of basal-like breast cancer
Authors: Rashid Narmeen S. , Boyd David C. , Olex Amy L. , Grible Jacqueline M. , Duong Alex K. , Alzubi Mohammad A. , Altman Julia E. , Leftwich Tess J. , Valentine Aaron D. , Hairr Nicole S. , Zboril Emily K. , Smith Timothy M. , Pfefferle Adam D. , Dozmorov Mikhail G. , Harrell J. Chuck
Published: December 2022

The goals of this study were to identify transcriptomic changes that arise in basal-like breast cancer cells during the development of resistance to epidermal growth factor receptor inhibitors (EGFRi) and to identify drugs that are cytotoxic once EGFRi resistance occurs. Human patient-derived xenografts (PDXs) were grown in immunodeficient mice and treated with a set of EGFRi; the EGFRi erlotinib was selected for more expansive in vivo studies. Single-cell RNA sequencing was performed on mammary tumors from the basal-like PDX WHIM2 that was treated with vehicle or erlotinib for 9 weeks. The PDX was then subjected to long-term erlotinib treatment in vivo. Through serial passaging, an erlotinib-resistant subline of WHIM2 was generated. Bulk RNA-sequencing was performed on parental and erlotinib-resistant tumors. In vitro high-throughput drug screening with > 500 clinically used compounds was performed on parental and erlotinib-resistant cells. Previously published bulk gene expression microarray data from MMTV-Wnt1 tumors were contrasted with the WHIM2 PDX data. Erlotinib effectively inhibited WHIM2 tumor growth for approximately 4 weeks. Compared to untreated cells, single-cell RNA sequencing revealed that a greater proportion of erlotinib-treated cells were in the G1 phase of the cell cycle. Comparison of WHIM2 and MMTV-Wnt1 gene expression data revealed a set of 38 overlapping genes that were differentially expressed in the erlotinib-resistant WHIM2 and MMTV-Wnt1 tumors. Comparison of all three data types revealed five genes that were upregulated across all erlotinib-resistant samples: IL19, KLK7, LCN2, SAA1, and SAA2. Of these five genes, LCN2 was most abundantly expressed in triple-negative breast cancers, and its knockdown restored erlotinib sensitivity in vitro. Despite transcriptomic differences, parental and erlotinib-resistant WHIM2 displayed similar responses to the majority of drugs assessed for cytotoxicity in vitro. This study identified transcriptomic changes arising in erlotinib-resistant basal-like breast cancer. These data could be used to identify a biomarker or develop a gene signature predictive of patient response to EGFRi. Future studies should explore the predictive capacity of these gene signatures as well as how LCN2 contributes to the development of EGFRi resistance.
Bioactivity and phenolics profile of aqueous and ethyl acetate extracts of Satureja kitaibelii Wierzb. ex Heuff. obtained by ultrasound-assisted extraction
Authors: Gopčević Kristina , Grujić Slavica , Arsenijević Jelena , Džamić Ana , Veličković Ivona , Izrael-Živković Lidija , Medić Ana , Mudrić Jelena , Soković Marina , Đurić Ana
Published: December 2022

The aim of the study was to investigate the biological activity and chemical composition ofSatureja kitaibeliiWierzb. ex Heuff. LC–PDA/MS analyses for the aqueous extracts (A1-stem, leaves and flowers, A2-leaves and flowers) and ethyl-acetate extracts (E1-stem, leaves and flowers, E2-leaves and flowers) obtained by ultrasound-assisted extraction enabled the identification of thirty-four compounds. Quantitative analysis revealed that the aqueous extract obtained from leaves and flowers was the richest in total phenolic acids (65.36 mg/g) and flavonoids (21.17 mg/g). The total polyphenol content was the highest in the aqueous extract obtained from leaves and flowers (274 ± 2.4 mg Gallic Acid equivalents/g). The best antioxidant activity was observed for the same extract using the DPPH (SC50 20 ± 10 µg/mL), ABTS (2.834 ± 0.02 mg Ascorbic Acid/g), FRAP (1.922 ± 0.03 mmol Fe2+/mg), and total reducing power tests (16.4 ± 1.0 mg Ascorbic Acid/g). Both ethyl acetate extracts were the most active against strains ofBacillus cereusandMicrococcus flavus(MIC 1.70–1.99 mg/mL and 1.99–3.41 mg/mL, respectively). They were more efficient againstAspergillus ochraceus(MFC 0.86 mg/mL) and towards HeLa cell lines. All the obtained results implied the good potential of the investigated extracts to be used as effective preservatives and functional ingredients in food products and dietary supplements.
DNA methylation and expression of the egfr gene are associated with worker size in monomorphic ants
Authors: Renard Thibaut , Gueydan Cyril , Aron Serge
Published: December 2022

The reproductive division of labour is a hallmark of eusocial Hymenoptera. Females are either reproductive queens or non-reproductive workers. In ants, workers often display further task specialisation that is associated with variation in size and/or morphology. Because female polyphenism is typically under environmental control, it is thought epigenetic mechanisms (such as DNA methylation) play a central role since they mediate gene-by-environment interactions. Methylation of the growth-promoting geneepidermal growth factor receptor(egfr) was indeed shown to control worker size in a highly polymorphic ant. However, it remains unknown ifegfrmethylation could also regulate worker size in monomorphic species. By combining experimental pharmacology and molecular biology, we show that worker size is associated withegfrmethylation in two monomorphic ants. Furthermore, we functionally demonstrate that EGFR signalling affects worker size. These results indicate that worker size regulation byegfrmethylation has been mechanistically conserved in ants but remains unexploited in monomorphic species.
Nonlinear Rayleigh wave propagation in thermoelastic media in dual-phase-lag
Authors: Youssef A. A. , Amein N. K. , Abdelrahman N. S. , Abou-Dina M. S. , Ghaleb A. F.
Published: December 2022

A model of generalized thermoelasticity within dual-phase-lag is used to investigate nonlinear Rayleigh wave propagation in a half-space of a transversely isotropic elastic material. It is assumed that the coefficient of heat conduction is temperature-dependent, a fact that plays an important role in the coupling behaviour analysis of thermoelastic and piezo-thermoelastic solids. Taking such a dependence into account becomes a necessity at higher temperatures and in nano-structures, when the material properties can no longer be considered as constants. Normal mode analysis is applied to find a particular solution to the problem under consideration. A concrete case is solved under prescribed boundary conditions and tentative values of the different material coefficients. The results are discussed to reveal the effect of temperature dependence of the heat conduction coefficient, as well as the thermal relaxation times, on nonlinear Rayleigh wave propagation. All quantities of practical interest are illustrated in two-and three-dimensional plots. The presented results may be useful in the detection of the second harmonic amplitudes through measurements related to the propagating heat wave.
Bisphosphonate affects the behavioral responses to HCl by disrupting farnesyl diphosphate synthase in mouse taste bud and tongue epithelial cells
Authors: Oike Asami , Iwata Shusuke , Hirayama Ayaka , Ono Yurika , Nagasato Yuki , Kawabata Yuko , Takai Shingo , Sanematsu Keisuke , Wada Naohisa , Shigemura Noriatsu
Published: December 2022

Little is known about the molecular mechanisms underlying drug-induced taste disorders, which can cause malnutrition and reduce quality of life. One of taste disorders is known adverse effects of bisphosphonates, which are administered as anti-osteoporotic drugs. Therefore, the present study evaluated the effects of risedronate (a bisphosphonate) on taste bud cells. Expression analyses revealed that farnesyl diphosphate synthase (FDPS, a key enzyme in the mevalonate pathway) was present in a subset of mouse taste bud and tongue epithelial cells, especially type III sour-sensitive taste cells. Other mevalonate pathway-associated molecules were also detected in mouse taste buds. Behavioral analyses revealed that mice administered risedronate exhibited a significantly enhanced aversion to HCl but not for other basic taste solutions, whereas the taste nerve responses were not affected by risedronate. Additionally, the taste buds of mice administered risedronate exhibited significantly lower mRNA expression of desmoglein-2, an integral component of desmosomes. Taken together, these findings suggest that risedronate may interact directly with FDPS to inhibit the mevalonate pathway in taste bud and tongue epithelial cells, thereby affecting the expression of desmoglein-2 related with epithelial barrier function, which may lead to alterations in behavioral responses to HCl via somatosensory nerves.
Voice quality changes after functional endoscopic sinus surgery in patients with nasal polyps
Authors: Naruekon Jakkree , Kasemsiri Pornthep , Thanaviratananich Sanguansak , Prathanee Benjamas , Thongrong Cattleya , Reechaipichitkul Wisoot
Published: December 2022

Nasal polyps are associated with hyponasality. The effect of functional endoscopic sinus surgery (FESS) on voice quality has not been adequately investigated; therefore, this study developed objective and subjective measurements to compare nasal polyp patients pre- and postsurgery. An observational prospective study was conducted at Srinagarind Hospital, Khon Kaen University, Thailand. Bilateral nasal polyposis patients who underwent FESS between August 1, 2015 and August 1, 2017, were recruited. All participants were assessed for nasal polyp grade, nasometry, acoustic parameters, acoustic perception, and patient satisfaction before surgery and at the 1-, 3- and 6-month follow-ups. Forty-six patients, 29 males and 17 females (mean age 48.2 years ± 16.2 years), were enrolled. Mean nasometry scores were significantly improved at 1, 3 and 6 months after surgery (p < 0.05), whereas the acoustic parameters were not significantly different after surgery (p > 0.05). Overall acoustic perception, assessed with a set of words and sentences, showed significant improvement in hyponasality voice after surgery (p < 0.05), whereas GIRBAS showed no significant change after surgery in each parameter of perception (p > 0.05). Patient satisfaction with voice changes after surgery was high, with significantly increased mean scores between the 1- and 6-month follow-ups (p < 0.05). The results showed that FESS for nasal polyposis patients improved voice quality and patients’ voice satisfaction ratings.

Trial registration: This trial was registered at the Thai Clinical Trial Registry (TCTR20210324004).
Nocturnal hypoxemia is related to morning negative affectivity in untreated patients with severe obstructive sleep apnea
Authors: Kumagai Hajime , Sawatari Hiroyuki , Kiyohara Yuka , Kanoh Akiko , Asada Kana , Kawaguchi Kengo , Arita Aki , Murase Yoko , Konishi Noriyuki , Hoshino Tetsuro , Hayashi Mitsuo , Shiomi Toshiaki
Published: December 2022

The relationship between sleep apnea and morning affectivity remains unclear. We aimed to clarify how sleep disturbance in patients with obstructive sleep apnea (OSA) influences their affectivity. The enrolled participants underwent the Positive and Negative Affect Schedule on their beds immediately before and after overnight polysomnography. Thirty patients with OSA were divided into two groups according to the apnea–hypopnea index (AHI): mild to moderate OSA (5 ≤ AHI < 30/h) and severe OSA (AHI ≥ 30/h) groups. Additionally, 11 healthy participants (AHI < 5/h) were included as the control group. No independent association was found between affectivity and OSA severity markers in the whole population; however, the severe OSA group had a significantly higher cumulative percentage of sleep time at saturations < 90% (CT90) and worsened morning negative affectivity. Multiple regression analysis showed that CT90 was an independent factor for increasing negative affectivity in the severe OSA group (p = 0.0422). In patients with OSA, the receiver operating characteristic curve analysis showed that the best cutoff value for CT90 for predicting no decrease in negative affectivity after sleep was 1.0% (sensitivity = 0.56, specificity = 0.86); the corresponding area under the curve was 0.71. Worsening of negative affectivity in the morning was influenced by nocturnal hypoxemia in patients with severe OSA.
Correlation of photoreceptor damage with anti-retina antibodies level in aqueous humor in macular edema patients
Authors: Han Xinyao , Zhang Linqi , Tang Jiyang , Wang Zongyi , Li Siying , Yuan Li , Qu Jinfeng
Published: December 2022

This study aimed to investigate the correlation between the severity of photoreceptor damage and the level of anti-retina antibodies (ARAs) in aqueous humor, including recoverin, CA II and enolase-α IgG antibody of macular edema patients. Aqueous humor samples were collected from macular edema patients and from cataract patients. Patients were divided into three groups according to the severity of discontinuity of ellipsoid zone (EZ) shown on optical coherence tomography (OCT) imaging: cataract patients with intact EZ, macular edema patients with mild EZ damage, and macular edema patients with severe EZ damage. The level of ARAs was determined with enzyme-linked immunosorbent assay (ELISA). The correlation between the level of ARAs and the degree of photoreceptor damage was analyzed. The level of ARAs of the intact EZ group was significantly lower than that in the severely damaged group (P < 0.05). The level of recoverin IgG of the intact EZ group was significantly lower than mildly damaged group (P = 0.030). In a subgroup analysis, the level of recoverin IgG of DME patients was correlated with their central retinal thickness (CRT) (r = 0.462, P = 0.035). The level of ARAs in aqueous humor of patients with DME and RVO-ME was correlated with the degree of photoreceptor damage.
Filaggrin and cytokines in respiratory samples of preterm infants at risk for respiratory viral infection
Authors: Rodrigo-Muñoz José M. , Sastre Beatriz , Sánchez-García Laura , García-García María Luz , Gonzalez-Carrasco Ersilia , Fabra Celia , Gil-Martínez Marta , Lorente-Sorolla Clara , García-Latorre Raquel , Alcolea Sonia , Casas Inmaculada , Calvo Cristina , del Pozo Victoria
Published: December 2022

Respiratory viral infections (RVIs) are frequent in preterm infants possibly inducing long-term impact on respiratory morbidity. Immune response and respiratory barriers are key defense elements against viral insults in premature infants admitted to Neonatal Intensive Care Units (NICUs). Our main goals were to describe the local immune response in respiratory secretions of preterm infants with RVIs during NICU admission and to evaluate the expression and synthesis of lung barrier regulators, both in respiratory samples and in vitro models. Samples from preterm infants that went on to develop RVIs had lower filaggrin gene and protein levels at a cellular level were compared to never-infected neonates (controls). Filaggrin, MIP-1α/CCL3 and MCP-1 levels were higher in pre-infection supernatants compared to controls. Filaggrin, HIF-1α, VEGF, RANTES/CCL5, IL-17A, IL-1β, MIP-1α and MIP-1β/CCL5 levels were higher during and after infection. ROC curve and logistic regression analysis shows that these molecules could be used as infection risk biomarkers. Small airway epithelial cells stimulated by poly:IC presented reduced filaggrin gene expression and increased levels in supernatant. We conclude that filaggrin gene and protein dysregulation is a risk factor of RVI in newborns admitted at the NICU.
Multimode transistors and neural networks based on ion-dynamic capacitance
Authors: Liang Xiaoci , Luo Yiyang , Pei Yanli , Wang Mengye , Liu Chuan
Published: December 2022

Electrolyte-gated transistors can function as switching elements, artificial synapses and memristive systems, and could be used to create compact and powerful neuromorphic computing networks. However, insight into the underlying physics of such devices, including complex ion dynamics and the resulting capacitances, remains limited. Here we report a concise model for the transient ion-dynamic capacitance in electrolyte-gated transistors. The theory predicts that plasticity, high apparent mobility, sharp subthreshold swing and memristive conductance can be achieved—on demand—in a single transistor by appropriately programming the interfacial ion concentrations or matching the scan speed with ion motions. We then fabricate such multimode transistors using common solid-state electrolyte films and experimentally confirm the different capabilities. We also show in software that the multimode devices could be used to create neural networks that can be switched between conventional artificial neural networks, recurrent neural networks and spiking neural networks.
A mechanically tough and ultra-swellable microneedle for acute gout arthritis
Authors: Jiang Suping , Wang Wen , Ke Jiming , Huang Shan , Wang Jie , Luo Chengxi , Li Xiaoxia , Zhang Kaili , Liu Huanhuan , Zheng Wensheng , Zhang Jiwen , Peng Can
Published: December 2022

A tough and ultra-swellable microneedle was fabricated using in situ photopolymerization. Colchicine release was triggered by diffusion when microneedles were used on MSU-induced acute gout rats, resulting in decreased levels of inflammatory cytokines.
Additively manufactured thermosetting elastomer composites: small changes in resin formulation lead to large changes in mechanical and viscoelastic properties
Authors: Wang Ye , McAninch Ian M. , Delarue Antoine P. , Hansen Christopher J. , Robinette E. Jason , Peterson Amy M.
Published: December 2022

Better resin wettability increases strength and stiffness in high solids loading composites that can be additively manufactured with high resolution.
Local transplantation of GMSC-derived exosomes to promote vascularized diabetic wound healing by regulating the Wnt/β-catenin pathways
Authors: Liu Ziwei , Yang Shuo , Li Xiaoming , Wang Situo , Zhang Tong , Huo Na , Duan Ruixin , Shi Quan , Zhang Jianjun , Xu Juan
Published: December 2022

GMSCs-Exo promote proliferation, migration, and tube formation of HUVECs by regulating the Wnt/β-catenin signalling pathway in a high-glucose environment. GMSCs-Exo were loaded and delivered via PHE microspheres, novel porous microscaffolds with superb biocompatibility.
Isolation of cytotoxic daphnane-type and tigliane-type diterpenoids from Daphne genkwa using MetGem software
Authors: Mi Si-Hui , Duan Zhi-Kang , Wang Yu-Jue , Dong Shu-Hui , Zhao Peng , Yao Guo-Dong , Liu Qing-Bo , Lin Bin , Song Shao-Jiang , Huang Xiao-Xiao
Published: December 2022

Guided by MetGem Molecular Networking, eight daphnane-type and tigliane-type diterpenoids including four undescribed compounds were isolated from Daphne genkwa.
Synthesis of mono-nitroxides and of bis-nitroxides with varying electronic through-bond communication
Authors: Giannoulis Angeliki , Ackermann Katrin , Bogdanov Alexey , Cordes David B. , Higgins Catherine , Ward Joshua , Slawin Alexandra M. Z. , Taylor James E. , Bode Bela E.
Published: December 2022

The electron–electron exchange interaction (J) underpins quantum coherence phenomena. Here, synthetic strategies to moderate J in model compounds were evaluated with electron paramagnetic resonance spectroscopy.
An improved stereodivergent and practical synthesis of α- and β-pseudouridines
Authors: Barát Viktor , Chen Anqi , Lim Yee Hwee
Published: December 2022

A simplified stereodivergent and concise route featuring non-cryogenic conditions enable access to both anomers of pseudouridine.
Remotely controlled flow photo-Fries-type rearrangement of N-vinylazetidinones: an efficient route to structurally diverse 2,3-dihydro-4-pyridones
Authors: Dolna Magdalena , Narodowiec Jakub , Staszewska-Krajewska Olga , Szcześniak Piotr , Furman Bartłomiej
Published: December 2022

The photoexcited N-vinylazetidinones could undergo a ring expansion by a [1,3]-acyl shift to afford 2,3-dihydro-4-pyridones. A modular set-up was used for the studies in flow, with remote real-time control of the reaction course via UV-Vis.
A study of the conversion of ethanol to 1,3-butadiene: effects of chemical and structural heterogeneity on the activity of MgO–SiO2 mixed oxide catalysts
Authors: Szabó Blanka , Hutkai Virág , Novodárszki Gyula , Lónyi Ferenc , Pászti Zoltán , Fogarassy Zsolt , Valyon József , Barthos Róbert
Published: December 2022

MgO–SiO2 catalysts were synthesized by using non-porous and mesoporous MgO for ethanol to butadiene reaction. Significantly higher butadiene yields were achieved over mesoporous MgO based catalysts.
Narrowband photoresponse of a self-powered CuI/SrTiO3 purple light detector with an ultraviolet-shielding effect
Authors: Zhang Yong , Liu Hui , Liu Shuai , Gong Qian , Liu Yushen , Tian Dan , Kang Lixing
Published: December 2022

The CuI/SrTiO3 photodetector presents excellent self-powered characteristics and shows a narrowband photoresponse at zero bias. This device shows a transparency of 70% over the visible light region and blocks 99.9% UV light.
The Factors Affecting Building Damage in Balitata Village Due to 7.2 Magnitude Earthquake
Authors: Harisun Endah , Purnomo Hery , Haryati
Published: December 2022

The strength of the building's response to earthquakes is primarily determined by building construction. The earthquake in the southern part of Halmahera Regency destroyed thousands of homes. Specifically, in Balitata village affected by the earthquake, there were dozens of damaged houses. This study was conducted to determine the cause of house collapse without considering the shear forces caused by earthquakes, while the research method used was qualitative descriptive. The conclusions obtained were many factors that caused dozens of houses to collapse in Balitata village
Evaluation of the Lightning Protection System at the Khairun University Rectorate Building
Authors: Masri Rifan , Djufri Idham A. , Rasyid Ramly
Published: December 2022

Multi-story buildings must be equipped with lightning protection to prevent direct lightning strikes. This study aims to evaluate the lightning protection system in the Khairun University rectorate building using the rolling ball method. The estimated hazard of lightning strikes based on PUIPP is 14, so the Khairun University rectorate building needs SPP. With a height of 27 meters and an efficiency value of SPP E = 0.22. Thus, the Khairun University rectorate building is not known for its level of SPP needs. The rectorate building of Khairun University with the rolling ball method has a radius of protection known from the efficiency table for the value of 0.22 does not exist. Thus, the calculation of the radius of the protected area cannot be used. The ground resistance in the Khairun University rectorate building does not meet the PUIL 2000 standard with a standard value of not more than 5 Ohms.
E-Government Risk Optimization Capability Measurement
Authors: Wulansari Anita , Prasetyo Carena Learns , Mukaromah Siti , Kartika Dhian Satria Yudha , Safitri Eristya Maya , Najaf Abdul Rezha Efrat
Published: December 2022

Bureau XYZ strived to facilitate the realization of good governance through electronic government (e-government). There were various information systems that were implemented as part of this effort, one of which was the mail management information system. Bureau XYZ has implemented an Information Security Management System (ISMS) using ISO 27001:2013 standards. Nevertheless, optimization and management of information technology risks were necessary to ensure that the implementation of the software was in accordance with the capabilities and objectives of the organization. Therefore, it was necessary to measure the capability level to determine the actions that need to be taken to improve information security risk management in implementing the software. This study aimed to obtain the capability level of the mail management information system's information security risk management process, find out the gap between the actual and desired capability level and provide recommendations for improvement according to COBIT 5. This study measured the EDM03-Ensure Risk Optimization process. The assessment results showed that the EDM03 process was at Level 1 (Performed) and had a gap value of 2 from the desired capability level, Level 3 (Established). Recommendations for improvement were also included in this study to help the organization achieve the desired level based on the assessment results, list of findings, and validation of work products.
The Application Construction of Fala Kanci as Healthy House for The Future
Authors: Andriani Tiara Puput , Marasabessy Firdawaty , Muhammad Asri A
Published: December 2022

House is everything during the current Covid-19 pandemic. The house does not only function as a place to live, but more than that it is used for work, study, sports, and others. The concept of a healthy home that must be presented during this pandemic cannot be separated from the washing of health protocols, namely an optimized natural ventilation system, the availability of isolation rooms in each home, and the provision of hand sanitizing facilities (washtafel). The concept of structuring houses in traditional houses in North Maluku is following the concept of the current health protocol. Considering that the concept of traditional houses, especially people's houses, in several aspects are following health protocols, for this reason, it is necessary to model a healthy house after the Covid-19 pandemic to get a decent healthy house as a mitigation effort from biological disasters. The purpose of this study was to observe traditional houses that apply the principles of health protocols and the basics of these houses in the form of concept drawings.The result of the research is to make a new prototype to be modeled by considering natural ventilation systems, social distancing, and sanitation systems.
A Desk Study Based on SWOT Analysis: An Adaptation of Life Cycle Assessment (LCA) in the Pulp and Paper Industry
Authors: Pulansari Farida , Nugraha Isna , Adi Saputro Erwan
Published: December 2022

Today, the industrial world is experiencing intense competition with challenges related to environmental issues, and the domestic paper industry is no exception. This study is a follow-up of the research conducted by Palupi et al. (2015) at Company X which, through an LCA study, found an acute water ecotoxicity value of 7.16 kPt, a chronic water ecotoxicity value of 6.5 kPt, and a soil human toxicity value of 2.69 kPt. However, that study did not come with a SWOT matrix. Therefore, using a desk study,the present study aimed to map a SWOT matrix. A desk study based on SWOT analysis from 12 international journals and two national journals sourced from Elsevier, IWA Publishing, MDPI Publisher, Taylor & Francis, and Garuda was used to determine the SWOT matrix. Desk studies have the objective of comprehensively evaluating published journal articles, books, and other sources on given problem domains.Based on the results of the study, some recommendations for actions on the internal and external factors of the company are offered, consiting of steps for the company to mitigate identified weaknesses and threats.This study found that most of the pulp and paper industry engaged in internal strengths and external opportunities and faced numerous internal weaknesses and external threats. Currently, Company X occupied the first quadrant (Growth), indicating that the company was in a highly profitable condition. The company was enjoying many strengths and opportunities. Therefore, it is critical for the company to use its strengths to capture opportunities to minimize its emissions to the environment and to implement LCA in the company.
Rainfall Prediction Using Backpropagation with Parameter Tuning
Authors: Setiawan Wahyudi , Barokah Asyroful , Mula’ab
Published: December 2022

Rainfall is one of the important elements in the process of weather and climate. The high intensity of rainfall every year can hamper the mobility of the population and the distribution of goods, especially in the port area. Rainfall prediction is needed to handle the impacts caused by high rainfall. The data was obtained from the website dataonline.bmkg.go.id with observations made by the Tanjung Perak Surabaya Maritime Meteorological Station. The prediction method uses an artificial neural network with Backpropagation. Autocorrelation function is used to determine the number of input neurons with the best features in the Artificial Neural Network. Rainfall data is divided into two parts,: January 2008 to December 2019 used for training data and January to August 2020 for testing data. The validation technique used is 10-Fold Cross Validation. The experiment uses parameter tuning of iteration and learning rate. The training process obtained the best learning rate was 0.2 and 1000 iterations with a MSE validation score of 0.02591.Finally, the testing process has a Mean Square Error value of 0.02769 and a percentage of true rain character of 62.5%.
Work Posture Simulation Using Catia VSR20 at Virgin Coconut Oil Production
Authors: Latif Lita Asyriati , Munim Yulinda Sakinah , Harbelubun M. Muzni , Rais Sandi , Abbas M. Fadly Hi.
Published: December 2022

This study aims to measure the posture of a worker by analyzing the level of occupational health risk and the level of fatigue of the physical load in a posture with a high level of posture risk and proposes to improve posture to reduce the risk of musculoskeletal disorders. RULA is a method used to evaluate work posture, CATIA V5R20 software is used to simulate workers while doing work, and heart rate are the data used to identify the level of physical workload. The results of the work posture analysis show that the workers at station coconut husk stripping have the highest level of risk with a RULA score of 7 (red), which means that the work is very tiring and at risk of experiencing MSDs and needs to improve immediately.Based on the analysis of the classification of physical workloads, it shows that 76% of the coconut husk stripping work activity is a heavy and tiring workload category for the work. The proposed posture improvement shows a decrease in score.
Determination of Ginger Simplicial Marketing Strategy in Madura with EFE and IFE Matrix Approach
Authors: Widiaswanti Ernaning , Yunitarini Rika , Indriartiningtias Retno
Published: December 2022

Ginger plants have the potential for business to be developed. Part of the ginger plant that is commonly utilized is rhizome. Zingiber rhizome is processed first before storing or selling, one of the ways is in the form of simplicia. Ginger simplicia is often used as a basic ingredient of herbal medicine. Madura Island has a reputation as one of the herbs that have been tested by the National empirical use. Many herbal medicine industries in Madura use ginger simplicia as their raw material. In Madura, ginger simplicia is majorly produced by SMEs. The problems faced by SMEs in Madura are the distribution channels that are not well ordered, lack of venture capital, technology is still very simple, competition with similar businesses both from within and outside the region, and changes in raw material prices. The aim of this research was to formulate a priority marketing strategy for ginger simplicia that can be carried out by SMEs in Madura.The analytical methods used are IFE matrix, EFE matrix, IE matrix, and SWOT matrix. The results of the analysis show 4 priority strategies that can be applied
Waisenhilfe statt Orphan Drugs
Authors: Aldag Ulrike
Published: December 2022

Unter einem nicht pharmakologischen Gesichtspunkt existieren durchaus interessante Besserungs- oder sogar Heilungsmöglichkeiten. Alternativinteressierte können dazu vom funktionell-informativen Wissen über die Fähigkeiten des vegetativen Nervensystems profitieren. Dieses überall vernetzte autonome Nervensystem agiert automatisch, unterbewusst und besonders über Organgeflechte als psychosomatischer Koppler. Hat das Gehirn anamnestisch schlechte Eindrücke auf Geist-, Körper- oder Seelenebene erlebt, kann jede Erfahrungsnarbe im Körpergedächtnis über dieselbe Meldestrecke überschrieben (= entstört) werden. Jede Krankheit bringt negative Erlebnisse als Symptome zum Ausdruck. Deshalb können auch Symptomenkomplexe seltener Erkrankungen mit körperlicher Neuraltherapie plus psychoemotionaler Techniken verblassen, solange noch keine Dialyse nötig ist. Werden akute Symptome prinzipiell regulationsmedizinisch behandelt, kommt es eher nicht zur Chronizität.
Hydrology and runoff water quality from three improved pastures compared with virgin brigalow (
Authors: Elledge Amanda , Thornton Craig
Published: December 2022

The Fitzroy Basin in central Queensland has the largest cattle herd of any natural resource management region in Australia, and legumes have been widely used to boost fertility of rundown soil and improve cattle liveweight gains. However, there is a paucity of information on the effect of leguminous pastures on hydrology and water quality. This study investigated runoff water quality over eight hydrological years from virgin brigalow (Acacia harpophylla) woodland and three improved pastures, namely, buffel grass (Pennisetum ciliare), butterfly pea (Clitoria ternatea) and leucaena (Leucaena leucocephala). Runoff event mean concentrations and loads of total and dissolved nitrogen, phosphorus, and carbon in addition to total suspended solids are reported. Brigalow woodland had the greatest loss of sediment and nitrogen attributed to the inherently fertile Vertosols (clay soil), but the low occurrence and amount of runoff meant that it had a low risk to water quality. Despite a similar number of runoff events from the improved pastures, leucaena pasture had less total runoff and a lower maximum peak runoff rate in addition to lower nitrogen and carbon in runoff. Total suspended solids and carbon in runoff were greater from grass pasture than from the leguminous pastures, whereas nitrogen and phosphorus were greatest from the butterfly pea pasture, especially in the first 2 years post-planting. Greater exports of phosphorus from the improved pastures were concerning, given the potential for downstream impacts.
A dynamic and evidence-based approach to mapping burn potential
Authors: van Dongen Richard , Ruscalleda-Alvarez Jaume , Gosper Carl R.
Published: December 2022

Background Fire management is a crucial part of managing ecosystems. The years since last burn (YSLB) metric is commonly used in fire planning to predict when an area might be suitable to burn; however, this metric fails to account for variable recovery due to climate variability. Aim The aim of this study was to develop a predictor of when an area may be able to ‘carry’ fire based on observed patterns of vegetation recovery and fire occurrence that is responsive to climate variability. Methods Fire history maps and Landsat satellite imagery within the Great Victoria Desert of Australia were used to map vegetation recovery following fire. Burn potential models were then created by calculating the distributions of YSLB and vegetation recovery values for areas that subsequently burnt. Key result A burn potential model based on vegetation recovery is a better predictor of when an area is likely to burn than a model based on YSLB. Conclusions A burn potential model based on vegetation recovery provides an evidence-based and dynamic assessment of whether an area is likely to burn. Implications This approach provides a model that is responsive to climate variability that can assist fire managers in burn planning and assessing fire risk.
Cross-cultural differences in mental representations of diagonal time lines
Authors: Yang Wenxing , Dong Jiaqi , Bi Ruidan , Gu Jian , Feng Xueqin
Published: December 2022

Accumulating evidence over the last two decades has established that people represent elapsing time along a
horizontal or a vertical mental time line (MTL). A recent research (Hartmann et al.,
2014) discovered an additional diagonal MTL which develops from bottom left to top right. The present study sought to
extend Hartmann et al.’s (2014) work by exploring if the particular representations of
diagonal time lines vary across cultures. Two experiments which recruited English and Arabic speakers as participants were
conducted. The experimental setups measured participants’ space-time mappings along the bottom-left/top-right,
top-left/bottom-right, bottom-right/top-left and top-right/bottom-left axes. Converging evidence demonstrates that there are
indeed cross-cultural differences in mental representations of diagonal time lines. While English speakers displayed a salient
propensity to conceive of time as oriented from bottom left to top right, Arabic speakers favored a time line unfolding from
bottom right to top left. To the best of our knowledge, this study is the first to investigate if diagonal MTLs are
cross-culturally represented. Findings of the present study add to existing literature by highlighting the important role of
cultural artifacts such as writing direction in structuring people’s MTLs. Writing directions not only bring about cross-cultural
discrepancies in space-time associations along the horizontal axis (e.g., left-to-right for English speakers and right-to-left for
Arabic speakers), but also affect the creation of culturally specific concepts of diagonal time lines.
Conceptual metaphor in trading card games
Authors: Papišta Žolt
Published: December 2022

The current study aims to demonstrate that trading card games (TCGs), also called collectible card games (CCGs),
represent a potentially fruitful area of research in metaphor studies. A popular trading card game called
Yu-Gi-Oh! is examined, and the argument is made that players utilize the cognitive mechanisms of conceptual
metaphor to conceptualize its core game mechanics. Based on the results of a survey (n = 186) it was concluded
that players conceptualize such game mechanics in line with the logics inherent in the Location Event Structure Metaphor, in
conjunction with the metaphors birth is arrival, life is being present here, and death is departure.
This implies that it is precisely the embodied cognitive mechanisms of conceptual metaphor which allow for a shared,
intersubjective understanding between players to exist regarding the meanings of various gameplay scenarios in
Yu-Gi-Oh!, and possibly in many other trading card games as well.
Effects of bypass-current and out plasma current on droplet transfer behaviours during plasma-MIG hybrid arc welding
Authors: Miao Yugang , Wang Ziran , Wang Lin , Ma Xubo , Deng Qingwen , Zhang Benshun
Published: December 2022

A new method, bypass-current plasma-MIG hybrid arc welding, was proposed to weld AA 5083 aluminium alloy. A comparative investigation between simulation and experiment was performed to quantify different effects of bypass-current and out plasma current on droplet transfer behaviours. The results show that when the bypass-current is 15 A, the droplets present a projected transfer mode, and its period is 22 ms. But if the outer plasma current is 15 A, the transfer frequency increases 19.1 Hz, and the sizes of the droplet show a slight increase. This is due to the reduction of electromagnetic force and arc plasma force on droplets. The research outcomes provide benefits to the droplet transfer behaviours in control and optimisation during aluminium alloy welding.