bluuebunny/crossref_metadata_2025 huggingface dataset:
A phenotypic model recapitulating the neuropathology of Parkinson's disease
Authors: Ferris Craig F. , Marella Mathieu , Smerkers Brian , Barchet Thomas M. , Gershman Benjamin , Matsuno‐Yagi Akemi , Yagi Takao
Published: April 2013

This study was undertaken to develop a phenotypic model recapitulating the neuropathology of Parkinson's disease (PD). Such a model would show loss of dopamine in the basal ganglia, appearance of Lewy bodies, and the early stages of motor dysfunction. The model was developed by subcutaneously injecting biodegradable microspheres of rotenone, a complex I inhibitor in 8–9 month old, ovariectomized Long–Evans rats. Animals were observed for changes in body weight and motor activity. At the end of 11–12 weeks animals were euthanized and the brains examined for histopathological changes. Rotenone treated animals gain weight and appear normal and healthy as compared to controls but showed modest hypokinesia around 5–6 weeks posttreatment. Animals showed loss of dopaminergic (DA) neurons and the appearance of putative Lewy bodies in the substantia nigra. Neuroinflammation and oxidative stress were evidenced by the appearance of activated microglia, iron precipitates, and 8‐oxo‐2′‐deoxyguanosine a major product of DNA oxidation. The dorsal striatum, the projection site of midbrain DA neurons, showed a significant reduction in tyrosine hydroxylase immunostaining, together with an increase in reactive astrocytes, an early sign of DA nerve terminal damage. Levels of vesicular monoamine transporter 2 (VMAT2) were significantly reduced in the dorsal striatum; however, there was an unexpected increase in dopamine transporter (DAT) levels. Old, ovariectomized females treated with rotenone microspheres present with normal weight gain and good health but a modest hypokinesia. Accompanying this behavioral phenotype are a constellation of neuropathologies characteristic of PD that include loss of DA neurons, microglia activation, oxidative damage to nuclear DNA, iron deposition, and appearance of putative Lewy bodies. This phenotypic model recapitulating the neuropathology of Parkinson's disease could provide insight into early mechanisms of pathogenesis and could aid in the identification of biomarkers to identify patients in early stage, PD.
B6eGFPChAT mice overexpressing the vesicular acetylcholine transporter exhibit spontaneous hypoactivity and enhanced exploration in novel environments
Authors: Nagy Paul M. , Aubert Isabelle
Published: April 2013

Cholinergic innervation is extensive throughout the central and peripheral nervous systems. Among its many roles, the neurotransmitter acetylcholine (ACh) contributes to the regulation of motor function, locomotion, and exploration. Cholinergic deficits and replacement strategies have been investigated in neurodegenerative disorders, particularly in cases of Alzheimer's disease (AD). Focus has been on blocking acetylcholinesterase (AChE) and enhancing ACh synthesis to improve cholinergic neurotransmission. As a first step in evaluating the physiological effects of enhanced cholinergic function through the upregulation of the vesicular acetylcholine transporter (VAChT), we used the hypercholinergic B6eGFPChAT congenic mouse model that has been shown to contain multiple VAChT gene copies. Analysis of biochemical and behavioral paradigms suggest that modest increases in VAChT expression can have a significant effect on spontaneous locomotion, reaction to novel stimuli, and the adaptation to novel environments. These observations support the potential of VAChT as a therapeutic target to enhance cholinergic tone, thereby decreasing spontaneous hyperactivity and increasing exploration in novel environments.
Polyethylene glycol‐based low generation dendrimers functionalized with β‐cyclodextrin as cryo‐ and dehydro‐protectant of catalase formulations
Authors: Santagapita Patricio R. , Mazzobre M. Florencia , Cruz Ariel García , Corti Horacio R. , Villalonga Reynaldo , Buera M. Pilar
Published: April 2013

Polyethylene glycol (PEG)‐based low generation dendrimers are analyzed as single excipient or combined with trehalose in relation to their structure and efficiency as enzyme stabilizers during freeze‐thawing, freeze‐drying, and thermal treatment. A novel functional dendrimer (DGo‐CD) based on the known PEG's ability as cryo‐protector and β‐CD as supramolecular stabilizing agent is presented. During freeze‐thawing, PEG and β‐CD failed to prevent catalase denaturation, while dendrimers, and especially DGo‐CD, offered the better protection to the enzyme. During freeze‐drying, trehalose was the best protective additive but DGo‐CD provided also an adequate catalase stability showing a synergistic behavior in comparison to the activities recovered employing PEG or β‐CD as unique additives. Although all the studied dendrimers improved the enzyme remaining activity during thermal treatment of freeze‐dried formulations, the presence of amorphous trehalose was critical to enhance enzyme stability. The crystallinity of the protective matrix, either of PEG derivatives or of trehalose, negatively affected catalase stability in the freeze‐dried systems. When humidified at 52% of relative humidity, the dendrimers delayed trehalose crystallization in the combined matrices, allowing extending the protection at those conditions in which normally trehalose fails. The results show how a relatively simple covalent combination of a polymer such as PEG with β‐CD could significantly affect the properties of the individual components. Also, the results provide further insights about the role played by polymer–enzyme supramolecular interactions (host–guest crosslink, hydrogen bonding, and hydrophobic interactions) on enzyme stability in dehydrated models, being the effect on the stabilization also influenced by the physical state of the matrix. © 2013 American Institute of Chemical Engineers Biotechnol. Prog., 29:786–795, 2013
Hemorheological implications of perfluorocarbon based oxygen carrier interaction with colloid plasma expanders and blood
Authors: Vásquez Diana M. , Ortiz Daniel , Alvarez Oscar A. , Briceño Juan C. , Cabrales Pedro
Published: April 2013

Perfluorocarbon (PFC) emulsions used as artificial oxygen carriers lack colloid osmotic pressure (COP) and must be administered with colloid‐based plasma expanders (PEs). Although PFC emulsions have been widely studied, there is limited information about PFC emulsion interaction with PEs and blood. Their interaction forms aggregates due to electrostatic and rheological phenomena, and change blood rheology and blood flow. This study analyzes the effects of the interaction between PFC emulsions with blood in the presence of clinically‐used PEs. The rheological behavior of the mixtures was analyzed in vitro in parallel with in vivo analysis of blood flow in the microcirculation using intravital microscopy, when PEs were administered in a clinically relevant scenario. The interaction between the PFC emulsion and PE with blood produced PFC droplets and red blood cell (RBCs) aggregation and increased blood viscosity in a shear dependent fashion. The PFC droplets formed aggregates when mixed with PEs containing electrolytes, and the aggregation increased with the electrolyte concentration. Mixtures of PFC with PEs that produced PFC aggregates also induced RCBs aggregation when mixed with blood, increasing blood viscosity at low shear rates. The more viscous suspension at low shear rates produced a blunted blood flow velocity profile in vivo compared to nonaggregating mixtures of PFC and PEs. For the PEs evaluated, human serum albumin produced minimal to undetectable aggregation. PFC and PEs interaction with blood can affect sections of the microcirculation with low shear rates (e.g., arterioles, venules, and pulmonary circulation) when used in a clinical setting, because persistent aggregates could cause capillary occlusion, decreased perfusion, pulmonary emboli or focal ischemia. © 2013 American Institute of Chemical Engineers Biotechnol. Prog., 29:796–807, 2013
Cell‐based screening of traditional chinese medicines for proliferation enhancers of mouse embryonic stem cells
Authors: Li Ding , Isherwood Sarah , Motz Andrew , Zang Ru , Yang Shang‐Tian , Wang Jufang , Wang Xiaoning
Published: April 2013

A high‐throughput cell‐based method was developed for screening traditional Chinese herbal medicines (TCHMs) for potential stem cell growth promoters. Mouse embryonic stem (mES) cells expressing enhanced green fluorescent protein (EGFP) were cultured in growth media supplemented with various TCHM extracts. The dosage‐dependent effects of TCHM extracts on cell growth, including proliferation and cytotoxicity, were assessed via EGFP fluorescence measurement. Seven TCHMs were investigated, and among them Panax notoginseng (PN), Rhizoma Atractylodis macrocephalae, Rhizoma chuanxiong, and Ganoderma lucidum spores (GLS) showed potential to improve mES cell proliferation. Eleven mixtures of these four TCHMs were then studied, and the results showed that the mixture of PN and GLS had the strongest growth promoting effect, increasing the specific growth rate of mES cells by 29.5% at a low dosage of 0.01% (wt/vol) PN/GLS (P < 0.01) and 34.2% at 0.1% (wt/vol) PN/GLS (P < 0.05) compared to the control. The growth promoting effect of PN/GLS was further confirmed with ES cells cultured in spinner flasks. A 29.3‐fold increase in the total cell number was achieved in the medium supplemented with 0.01% PN/GLS after 5 days, while the control culture only gave a 16.8‐fold increase. This cell‐based screening method thus can provide an efficient and high‐throughput way to explore potential stem cell growth promoters from TCHMs. © 2013 American Institute of Chemical Engineers Biotechnol. Prog., 29:738–744, 2013
Metabolic engineering of Clostridium acetobutylicum for the enhanced production of isopropanol‐butanol‐ethanol fuel mixture
Authors: Jang Yu‐Sin , Malaviya Alok , Lee Joungmin , Im Jung Ae , Lee Sang Yup , Lee Julia , Eom Moon‐Ho , Cho Jung‐Hee , Seung Do Young
Published: April 2013

Butanol is considered as a superior biofuel, which is conventionally produced by clostridial acetone‐butanol‐ethanol (ABE) fermentation. Among ABE, only butanol and ethanol can be used as fuel alternatives. Coproduction of acetone thus causes lower yield of fuel alcohols. Thus, this study aimed at developing an improved Clostridium acetobutylicum strain possessing enhanced fuel alcohol production capability. For this, we previously developed a hyper ABE producing BKM19 strain was further engineered to convert acetone into isopropanol. The BKM19 strain was transformed with the plasmid pIPA100 containing the sadh (primary/secondary alcohol dehydrogenase) and hydG (putative electron transfer protein) genes from the Clostridium beijerinckii NRRL B593 cloned under the control of the thiolase promoter. The resulting BKM19 (pIPA100) strain produced 27.9 g/l isopropanol‐butanol‐ethanol (IBE) as a fuel alcohols with negligible amount of acetone (0.4 g/l) from 97.8 g/l glucose in lab‐scale (2 l) batch fermentation. Thus, this metabolically engineered strain was able to produce 99% of total solvent produced as fuel alcohols. The scalability and stability of BKM19 (pIPA100) were evaluated at 200 l pilot‐scale fermentation, which showed that the fuel alcohol yield could be improved to 0.37 g/g as compared to 0.29 g/g obtained at lab‐scale fermentation, while attaining a similar titer. To the best of our knowledge, this is the highest titer of IBE achieved and the first report on the large scale fermentation of C. acetobutylicum for IBE production. © 2013 American Institute of Chemical Engineers Biotechnol. Prog., 29:1083–1088, 2013
Phase II study of TAS‐106 in patients with platinum‐failure recurrent or metastatic head and neck cancer and nasopharyngeal cancer
Authors: Tsao Anne , Hui Edwin Pun , Juergens Rosalyn , Marur Shanthi , Huat Tan Eng , Cher Goh Boon , Hong Ruey‐Long , Hong Waun Ki , Chan Anthony Tak‐Cheung
Published: April 2013

TAS‐106, a RNA polymerase inhibitor, was studied in solid tumors with potential clinical benefit and reasonable tolerability. We conducted a multicenter, international phase II trial of TAS‐106 in salvage metastatic or recurrent head and neck squamous cell cancer (HNSCC) and nasopharyngeal cancer (NPC) patients. TAS‐106 monotherapy was given at 6.5 mg/m2 over 24‐h continuous infusion every 3 weeks. Translational studies for blood and tissue were included. Twenty‐seven enrolled patients experienced the most common drug‐related adverse events of neutropenia, fatigue, non‐neutropenic fever, injection site reaction, and skin rash/dermatitis. The greater than or equal to grade 3 adverse events included neutropenia (14.8%), febrile neutropenia (7.4%), pneumonia (7.4%), and peripheral neuropathy (3.7%). The overall response rate was 0% in both subgroups; five HNSCC patients had stable disease (median duration 99 days) and four NPC patients had stable disease (median duration of 92.5 days). Median progression‐free survival (PFS) for HNSCC patients was 52 days (95% CI 43.0–99.0 days) and 48 days (95% CI 41.0–83.0 days) for NPC. Median overall survival (OS) for HNSCC patients was 175 days (95% CI 92.0–234.0 days) and 280 days (95% CI 107.0–462.0 days) for NPC. The TAS‐106 plasma levels were equivalent between Asian and Caucasian patients. There was no significant correlation of tumor UCK2 protein expression levels to TAS‐106 efficacy. TAS‐106 was reasonably tolerated in patients with platinum‐failure HNSCC and NPC. The administration schedule of 24‐h continuous infusion prevented neurologic toxicity, but had myelosuppression as its main toxicity. There was no anti‐tumor efficacy seen with TAS‐106 monotherapy. Future studies will focus on TAS‐106 combinations and mechanisms of drug resistance.
Subtypes of aggression in patients with schizophrenia: The role of personality disorders
Authors: Bo Sune , Forth Adelle , Kongerslev Mickey , Haahr Ulrik Helt , Pedersen Liselotte , Simonsen Erik
Published: April 2013

Background

Research has repeatedly demonstrated that schizophrenia has a small but significant association with violence. It is further recognised that a subgroup of people with such links also have personality disorders, but the extent to which type of violence or aggression varies according to subgroup is less clear.

Aim

This study aimed to investigate, among co‐morbid cases, if the number or type of personality disorders predicts type of aggression.

Methods

In a cross‐sectional study, 108 patients with schizophrenia were assessed for personality disorder, Axis‐I diagnosis, verbal IQ, social functioning and type of aggression.

Results

Logistic regression revealed that the more personality disorders identified (Cluster B personality disorders compared with Clusters A and C) and anti‐social personality disorder compared with other Cluster B disorders significantly predicted premeditated aggression.

Conclusions

These findings suggest that detailed personality assessment should be a routine part of comprehensive assessment of patients with schizophrenia. Improved knowledge of the presence and type of personality disorders may help detect and manage the risk of some types of aggression. Copyright © 2013 John Wiley & Sons, Ltd.
An evaluation and 20‐year follow‐up of a community forensic intellectual disability service
Authors: Lindsay William R , Steptoe Lesley , Wallace Lisa , Haut Fabian , Brewster Eleanor
Published: April 2013

Background

Since the middle of the 20th century, there have been several heterogeneous studies of recidivism by offenders with intellectual disabilities (ID) who have been in specialist mental health services after an index offence. Although some were long term, as befits a chronically needy group, laws and services have changed in that time. It may no longer be appropriate to rely on findings from the 1960s and 1970s.

Aims

To compare mental health presentations and recidivism between male sex offenders, men convicted of other offences and female offenders from a 1986–2008 cohort of offenders referred to specialist forensic ID services in Scotland.

Method

A 20‐year follow‐up of an assessment and treatment service for 309 offenders with ID (156 sex offenders, 126 non sexual male offenders and 27 women) was conducted.

Results

Sex offenders were more likely to be referred from the courts and had lower anger levels. Women were more likely to be diagnosed with mental illness. There was a split between groups with sex offenders committing few nonsexual offences and the other groups showing few sexual offences. During the study period, 16% of sexual offenders, 43% of male nonsexual offenders and 23% of women committed at least one further offence. Following assessment and treatment there was a 90–95% reduction in offending incidents.

Conclusions

Although recidivism rates are disappointing, harm reduction data suggests that assessment and treatment for offenders with ID can be highly successful in terms of public safety. Copyright © 2013 John Wiley & Sons, Ltd.
Assembly of Gold Nanoparticles on Functionalized Si(100) Surfaces through Pseudorotaxane Formation
Authors: Boccia Alice , D'Orazi Fabio , Carabelli Elena , Bussolati Rocco , Arduini Arturo , Secchi Andrea , Marrani Andrea G. , Zanoni Robertino
Published: April 2013

The assembly of gold nanoparticles (AuNPs) on a hydrogenated Si(100) surface, mediated by a series of hierarchical and reversible complexation processes, is reported. The proposed multi‐step sequence involves a redox‐active ditopic guest and suitable calix[n]arene‐based hosts, used as functional organic monolayers of the two inorganic components. Surface reactions and controlled release of AuNPs have been monitored by application of XPS, atomic force microscopy (AFM), field‐emission scanning electron microscopy (FESEM) and electrochemistry.
Columnar Self‐Assembly in Electron‐Deficient Heterotriangulenes
Authors: Kivala Milan , Pisula Wojciech , Wang Suhao , Mavrinskiy Alexey , Gisselbrecht Jean‐Paul , Feng Xinliang , Müllen Klaus
Published: April 2013

A series of soluble carbonyl‐bridged heterotriangulenes, in which flexible n‐dodecyl chains are attached through different spacers to the planar nitrogen‐centered polycyclic core, have been synthesized. The introduction of triisopropylsilylethynyl moieties enabled, for the first time, the characterization of single‐crystal columnar packing of a substituted heterotriangulene by X‐ray crystallography. Electrochemical studies disclosed the carbonyl‐bridged heterotriangulene core as a reasonably strong acceptor for a reversible two‐electron transfer. The tendency of substituted heterotriangulenes to self‐assemble in solution, on surfaces, and in the bulk appeared to sensitively depend on the nature of the lateral substituents, their steric demand, and the applied solution processing conditions. It can be concluded that 1) additional phenylene moieties between the heterotriangulene core and the n‐dodecyl chains facilitate self‐assembly by extending the π‐conjugated polycyclic disc, 2) the rod‐like ethynylene spacers introduce some additional flexibility and hence lower the overall aggregation tendency, and 3) the combination of both features in the phenylene–ethynylene moieties induces thermotropic liquid crystallinity.
ChemInform Abstract: Novel Environmentally Friendly Inorganic Yellow Pigments Based on CeO2—SiO2—Al2O3 —Bi2O3.
Authors: Wendusu Wendusu , Kato Daisuke , Masui Toshiyuki , Imanaka Nobuhito
Published: April 2013

Ce0.36Si0.31‐zBi0.33Alz O2‐(0.33+z)/2 with 0 ≤ z ≤ 0.13 is synthesized to enhance the thermal stability as well as the yellow hue of the previously reported yellow pigment Ce0.36Si0.31Bi0.33O1.835.
ChemInform Abstract: Color Point Tuning by Partial Ba2+ Substitution of Ca2+ in (Ca1‐xBax)3(PO4)2 Phosphor for White Light Emitting Diodes.
Authors: Xu Shiqing , et al. et al.
Published: April 2013

(Ca1‐xBax)3 (PO4)2:Eu2+ (x = 0, 0.051) phosphor is synthesized by solid state reaction of stoichiometric mixtures of BaCO3, CaCO3, NH4H2PO4, and Eu2O3 (5% H2/N2, 1300 °C, 3 h).
ChemInform Abstract: Template‐Free Solvothermal Synthesis and Enhanced Thermoelectric Performance of Sb2Te3 Nanosheets.
Authors: Sun Shaolin , Peng Jing , Jin Renxi , Song Shuyan , Zhu Pinwen , Xing Yan
Published: April 2013

Single‐crystalline Sb2Te3 nanosheets are prepared by a simple template‐free solvothermal approach using SbCl3, Na2TeO3, N2H4·H2O, and NH3 in ethylene glycol (autoclave, 473 K, 12 h).
ChemInform Abstract: Preparation of Multiferroic Co Substituted BiFeO3 with Enhanced Coercive Force and Its Application in Sorption Removal of Dye Molecules from Aqueous Solution.
Authors: Luo Lirong , Shen Kai , Xu Qingyu , Zhou Qin , Wei Wei , Gondal M. A.
Published: April 2013

The photocatalyst BiFeO3 and multiferroic Co substituted BiFeO3 (BiFe0.95Co0.05O3) perovskite are synthesized by a tartaric acid modified sol—gel method involving Bi(NO3)3, Fe(NO3)3, and Co(NO3)2 hydrates in stoichiometric proportions.
ChemInform Abstract: Toward Na‐Ion Batteries—Synthesis and Characterization of a Novel High Capacity Na Ion Intercalation Material.
Authors: Buchholz Daniel , Moretti Arianna , Kloepsch Richard , Nowak Sascha , Siozios Vassilios , Winter Martin , Passerini Stefano
Published: April 2013

The new Na+ ion intercalation compound Na0.45Ni0.22Co0.11Mn0.66 O2 is synthesized by solid state reaction of NaOH and Ni0.22Co0.11Mn0.66(OH)2 (1.
ChemInform Abstract: Intercalation of Sodium Ions into Hollow Iron Oxide Nanoparticles.
Authors: Koo Bonil , Chattopadhyay Soma , Shibata Tomohiro , Prakapenka Vitali B. , Johnson Christopher S. , Rajh Tijana , Shevchenko Elena V.
Published: April 2013

Cation vacancies in hollow γ‐Fe2O3 nanoparticles serve as hosts for sodium ions in the voltage range of 4.0—1.1 V.
ChemInform Abstract: Electrodeposition of CoxFe3‐xO4 Epitaxial Films and Superlattices.
Authors: He Zhen , Koza Jakub A. , Mu Guojun , Miller Andrew S. , Bohannan Eric W. , Switzer Jay A.
Published: April 2013

CoxFe3‐xO4 (0 < x < 1) thin films are prepared by a one‐step electrodeposition from alkaline Fe3+‐ and Co2+‐triethanolamine solutions.
ChemInform Abstract: A Simple Synthetic Route to Enantiopure α‐Hydroxy Ketone Derivatives by Asymmetric Hydrogenation.
Authors: Sun Tian , Zhang Xumu
Published: April 2013

High enantioselectivities are observed in the Rh‐catalyzed asymmetric hydrogenation of α‐ketone enol acetates using DuanPhos as the ligand.
ChemInform Abstract: Copper‐Catalyzed Enantioselective Allylic Substitution with Alkylboranes.
Authors: Shido Yoshinori , Yoshida Mika , Tanabe Masahito , Ohmiya Hirohisa , Sawamura Masaya
Published: April 2013

The first catalytic enantioselective substitution reaction with in situ generated alkylboron reagents proceeds with excellent γ‐selectivities and high enantioselectivities.
ChemInform Abstract: Asymmetric [4 + 3] Cycloadditions of Enantiomerically Enriched Epoxy Enolsilanes.
Authors: Lo Brian , Lam Sarah , Wong Wing‐Tak , Chiu Pauline
Published: April 2013

The title reaction of the enolsilane (I) gives a mixture of endo and exo cycloadducts with unexpected high enantioselectivity.
ChemInform Abstract: Lewis Acid Catalyzed Intramolecular Condensation of Ynol Ether‐Acetals. Synthesis of Alkoxycycloalkene Carboxylates.
Authors: Tran Vincent , Minehan Thomas G.
Published: April 2013

The title reaction catalyzed by scandium triflate affords several five‐, six‐, and even seven‐membered alkoxycycloalkene carboxylates in good yields.
ChemInform Abstract: Palladium‐Catalyzed Reactions of Enol Ethers: Access to Enals, Furans, and Dihydrofurans.
Authors: Lauer Matthew G. , Henderson William H. , Awad Amneh , Stambuli James P.
Published: April 2013

The present oxidation reaction of alkyl enol ethers to enals employs low loadings of the palladium catalyst.
ChemInform Abstract: Ruthenium‐Catalyzed C—H Bond Oxygenations with Weakly Coordinating Ketones.
Authors: Thirunavukkarasu Vedhagiri S. , Ackermann Lutz
Published: April 2013

Chemo‐ and siteselective oxygenation of aromatic ketones is achieved under optimized conditions.
ChemInform Abstract: Electrophilic α‐Amination Reaction of β‐Ketoesters Using N‐Hydroxycarbamates: Merging Aerobic Oxidation and Lewis Acid Catalysis.
Authors: Sandoval David , Frazier Charles P. , Bugarin Alejandro , de Alaniz Javier Read
Published: April 2013

The first α‐amination of carbonyls is developed by using nitrosoformate intermediates generated in situ from readily available N‐hydroxycarbamates.
ChemInform Abstract: Stille Couplings in Water at Room Temperature.
Authors: Lu Guo‐ping , Cai Chun , Lipshutz Bruce H.
Published: April 2013

The nonionic amphiphile TPGS‐750‐M enables efficient Stille coupling reactions between a wide range of substrates in water as the only medium.
ChemInform Abstract: One‐Pot Combination of the Wittig Olefination with Bromination and Oxidation Reactions.
Authors: Karama Usama , Mahfouz Refat , Al‐Othman Zeid , Warad Ismail , Almansour Abdulrahman
Published: April 2013

Z‐Configured‐bromo‐unsaturated esters (III) are obtained in a stereoselective one‐pot reaction.
ChemInform Abstract: Poly(N‐vinylimidazole) as an Efficient Catalyst for Acetylation of Alcohols, Phenols, Thiols and Amines under Solvent‐Free Conditions.
Authors: Khaligh Nader Ghaffari
Published: April 2013

The catalyst can be recovered and reused several times.
ChemInform Abstract: Transition‐Metal‐Free Synthesis of Aryl‐Substituted tert‐Butyl Ynol Ethers Through Addition/Elimination Substitution at an sp Centre.
Authors: Gray Vincent J. , Slater Ben , Wilden Jonathan D.
Published: April 2013

Treatment of arylated alkynyl sulfonamides with KOtBu in anhydrous DMF allows a new access to tert‐butyl ynol ethers via an addition/elimination pathway.
ChemInform Abstract: Chiral Copper(II)‐Catalyzed Enantioselective Boron Conjugate Additions to α,β‐Unsaturated Carbonyl Compounds in Water.
Authors: Kobayashi Shu , Xu Pengyu , Endo Toshimitsu , Ueno Masaharu , Kitanosono Taku
Published: April 2013

This is the first example of a chiral Cu(II)‐catalyzed asymmetric 1,4‐addition of diboron in water and has also the highest turnover frequency ever reported for an asymmetric boron conjugate addition reaction (TOF = 17,600 h‐1).
ChemInform Abstract: Carbolithiation of Styrenes with N‐tert‐Butyl Aldimines.
Authors: Liu Jie , Dang Hai‐Shan
Published: April 2013

A simple and straightforward route for the synthesis of 4‐phenyl‐substituted butanals is developed using carbolithiation of styrenes with lithiated aldimines.
ChemInform Abstract: Copper‐Catalyzed Aerobic Oxidative Synthesis of α‐Ketoamides from Methyl Ketones, Amines and NIS at Room Temperature.
Authors: Zhang Juan , Wei Ying , Lin Shaoxia , Liang Fushun , Liu Pengjun
Published: April 2013

A scalable, simple, efficient, and practical one‐pot procedure for the title synthesis is developed by using a cheap catalyst, readily available starting materials, and air as oxidant and oxygen source.
ChemInform Abstract: Efficient Pyridylbenzamidine Ligands for Palladium‐Catalyzed Suzuki—Miyaura Reaction.
Authors: Huang Ying‐Tang , Tang Xiao , Yang Yi , Shen Dong‐Sheng , Tan Cheng , Liu Feng‐Shou
Published: April 2013

The phosphine‐free ligand is successfully applied to the title reaction.
ChemInform Abstract: Synthesis of a New Palladium Salt Using N‐Benzyl DABCO Chloride and Its Application in Suzuki Reaction.
Authors: Hajipour Abdol Reza , Dehbane Ifa Mahboobi , Rafiee Fatemeh
Published: April 2013

An efficient catalytic system, which uses readily available and inexpensive materials, for the Suzuki cross‐coupling reaction is developed.
ChemInform Abstract: Direct Synthesis of Substituted Naphthalenes from 1,3‐Dicarbonyl Compounds and 1,2‐Bis(halomethyl)benzenes Including a Novel Rearrangement Aromatization of Benzo[c]oxepine.
Authors: Wang Jun‐gang , Wang Meng , Xiang Jia‐chen , Zhu Yan‐ping , Xue Wei‐jian , Wu An‐xin
Published: April 2013

Substituted naphthalene derivatives are obtained by rearrangement aromatization of benzo[c]oxepines (I).
ChemInform Abstract: Regioselective Prins Cyclization of Allenylsilanes. Stereoselective Formation of Multisubstituted Heterocyclic Compounds.
Authors: Okada Takuya , Shimoda Airi , Shinada Tetsuro , Sakaguchi Kazuhiko , Ohfune Yasufumi
Published: April 2013

The Prins cyclization of hydroxy‐substituted allenylsilanes such as (I) with carbonyl compounds is efficiently achieved with TmsOTf to yield 2,3‐dihydrofuran structures.
ChemInform Abstract: Microwave Heating for Rapid Conversion of Sugars and Polysaccharides to 5‐Chloromethyl Furfural.
Authors: Breeden S. W. , Clark J. H. , Farmer T. J. , Macquarrie D. J. , Meimoun J. S. , Nonne Y. , Reid J. E. S. J.
Published: April 2013

A range of carbohydrates such as fructose (I) and glucose (III) are rapidly and selectively converted to furfural derivative (III) using microwave heating in a biphasic reaction system.
ChemInform Abstract: Mild Synthesis of Furans with a Quaternary Carbon Substituent at the 2‐Position
Authors: Iwamoto Akihisa , Katori Aki , Sashihara Yoshiaki , Kojima Satoshi
Published: April 2013

via HFIP‐mediated reaction of (Z)‐4‐oxopentenal (II) with β‐dicarbonyl compounds
ChemInform Abstract: Polyaromatic Ribbon/Benzofuran Fusion via Consecutive Endo Cyclizations of Enediynes.
Authors: Byers Philip M. , Rashid Julian I. , Mohamed Rana K. , Alabugin Igor V.
Published: April 2013

Cross‐coupling of enediynes and iodophenol and subsequent cyclization result in the formation of a wide range of polyaromatic compounds.
ChemInform Abstract: Diastereoselective Synthesis of CF3‐Substituted, Epoxide‐Fused Heterocycles with β‐(Trifluoromethyl)vinylsulfonium Salts.
Authors: Fritz Sven P. , West Thomas H. , McGarrigle Eoghan M. , Aggarwal Varinder K.
Published: April 2013

Base‐promoted reaction of α‐functionalized carbonyl compounds with triflate (II) offers a diastereoselective approach to various heterobicyclic epoxides.
ChemInform Abstract: Reductive Cyclization of Bromoenynamides with Alcohols as Hydride Source: Synthesis and Reactions of 2‐Amidodienes.
Authors: Greenaway Rebecca L. , Campbell Craig D. , Chapman Helen A. , Anderson Edward A.
Published: April 2013

Bromoenynamides undergo cyclization to cyclic amidodienes, representing the first example of a carbopalladation/reduction cyclization process which employs an alcohol as hydride source, proceeding via β‐hydride elimination from a palladium alkoxide.
ChemInform Abstract: Iodine‐Mediated α‐Acetoxylation of 2,3‐Disubstituted Indoles.
Authors: Zaimoku Hisaaki , Hatta Takashi , Taniguchi Tsuyoshi , Ishibashi Hiroyuki
Published: April 2013

A new method for direct α‐functionalization of disubstituted indoles is developed.
ChemInform Abstract: A Facile Access to Enantioenriched Isoindolines via One‐Pot Sequential Cu(I)‐Catalyzed Asymmetric 1,3‐Dipolar Cycloaddition/Aromatization.
Authors: He Zhaolin , Liu Tanglin , Tao Haiyan , Wang Chun‐Jiang
Published: April 2013

The catalyst system allows the preparation of various derivatives in a diastereoselective manner with high enantioselectivities.
ChemInform Abstract: Cyclodienyl 1,3‐Dianionic Synthons: A Novel Synthesis of 5,5‐Dimethyl‐1,3‐bis‐(trimethylsilyl)cyclohexa‐1,3‐diene and Its Diels—Alder [π4s + π2s] Cycloadditions with Six Dienophiles.
Authors: Bhoothappa Venkatesh G. , Suresh HariPrasad
Published: April 2013

The first synthesis of the novel cyclic 1,3‐dianic synthon (IV) using a Wurtz—Fittig coupling reaction is described.
ChemInform Abstract: Generation and Cross‐Coupling of Benzyl and Phthalimide‐N‐oxyl Radicals in a Cerium(IV) Ammonium Nitrate/N‐Hydroxyphthalimide/ArCH2R System.
Authors: Terent'ev Alexander O. , Krylov Igor B. , Sharipov Mikhail Y. , Kazanskaya Zoya M. , Nikishin Gennady I.
Published: April 2013

Phthalimide (I) plays a dual role in the oxidative cross‐coupling reaction with alkylarenes (II) and (IV).
ChemInform Abstract: Propargyl Hydrazides: Synthesis and Conversion into Pyrazoles Through Hydroamination.
Authors: Yoshimatsu Mitsuhiro , Ohta Katsuki , Takahashi Nami
Published: April 2013

Coupling of propargyl alcohols with tosylhydrazine in the presence of Lewis acid provides a convenient approach to propargyl hydrazides.
ChemInform Abstract: Copper Catalyzed N‐Arylation of Amidines with Aryl Boronic Acids and One‐Pot Synthesis of Benzimidazoles by a Chan—Lam—Evans N‐Arylation and C—H Activation/C—N Bond Forming Process.
Authors: Li Jihui , Benard Sebastien , Neuville Luc , Zhu Jieping
Published: April 2013

Benzamidines are synthesized in two steps either via intermediate amidates or in a one‐pot procedure.
ChemInform Abstract: Copper on Iron: Catalyst and Scavenger for Azide—Alkyne Cycloaddition.
Authors: Kovacs Szabolcs , Zih‐Perenyi Katalin , Revesz Adam , Novak Zoltan
Published: April 2013

The Fe amount not only behaves as support for Cu but also represents a redox scavenger and reduces the copper contamination of the organic products.
ChemInform Abstract: Reaction of Oximes of α‐Diketones with Diphosphorous Tetraiodide for Preparation of Oxadiazoles and Nitriles.
Authors: Telvekar Vikas N. , Takale Balaram S.
Published: April 2013

Diphosphorous tetraiodide is used as mild agent for the simple dehydration of oximes to 1,2,5‐oxadiazole (IV), (VI), (VIII) as well as the rearrangement of oximes to normal Beckmann product 1,2,4‐oxadiazole (II).
ChemInform Abstract: Chemoselective Activities of Fe(III) Catalysts in the Hydrofunctionalization of Allenes.
Authors: Jung Min Seok , Kim Won Sun , Shin Ye Ho , Jin Ha Jeong , Kim Young Sam , Kang Eun Joo
Published: April 2013

The intramolecular hydroalkylation and hydroamination reactions of allenes in the presence of the iron catalysts afford tetrahydropyrans and piperidines, respectively.
ChemInform Abstract: Construction of Chiral Multi‐Functionalized Polyheterocyclic Benzopyran Derivatives by Using an Asymmetric Organocatalytic Domino Reaction.
Authors: Guo Zhi‐Wei , Li Xin‐Sheng , Zhu Wei‐Dong , Xie Jian‐Wu
Published: April 2013

This method yields fused benzopyran derivatives from electron‐deficient α,α‐dicyano olefins and nitrobenzopyrans in excellent diastereoselectivities and moderate to good enantioselectivities using a readily available bifunctional thiourea organocatalyst.
ChemInform Abstract: Rh‐Catalyzed C—C Cleavage of Benzyl/Allylic Alcohols to Produce Benzyl/Allylic Amines or Other Alcohols by Nucleophilic Addition of Intermediate Rhodacycles to Aldehydes and Imines.
Authors: Zhang Xi‐Sha , Li Yang , Li Hu , Chen Kang , Lei Zhi‐Quan , Shi Zhang‐Jie
Published: April 2013

This reaction proceeds via the transfer of a 2‐pyridyl‐aryl group.
ChemInform Abstract: Free‐Amine‐Directed Alkenylation of C(sp2)—H and Cycloamination by Palladium Catalysis.
Authors: Liang Zunjun , Ju Long , Xie Yongju , Huang Lehao , Zhang Yuhong
Published: April 2013

PdCl2/CuCO3‐mediated treatment of biaryl‐2‐amines with various alkenes like (II) and (VII) is found to allow a new, regio‐ and chemoselective access to phenanthridine derivatives.
ChemInform Abstract: Palladium‐Catalyzed Carbonylative Cyclization/Arylation Cascade for 2‐Aroylindolizine Synthesis.
Authors: Li Zhou , Chernyak Dmitri , Gevorgyan Vladimir
Published: April 2013

The present new synthesis of the title compounds proceeds via 5‐endo‐dig cyclization of an intermediate 2‐propargylpyridine triggered by an aroyl palladium complex.
ChemInform Abstract: An Expedient Phase Transfer Catalyst‐Mediated Synthesis of 2‐Alkyl/Aryl‐1,8‐phenanthrolines.
Authors: Chakrabarty Manas , Mukherji Ajanta
Published: April 2013

The first PTC‐mediated Skraup/Doebner—von Miller synthesis of the 1,8‐phenanthroline skeleton is given.
ChemInform Abstract: Cu(OAc)2‐Catalyzed Tandem Blaise/Pinner‐Type Reaction for One‐Pot Synthesis of Pyrimidin‐4‐ones.
Authors: Chun Yu Sung , Kim Ju Hyun , Choi Suh Young , Ko Young Ok , Lee Sang‐gi
Published: April 2013

A novel synthesis of the title compounds proceeds via reaction of nitriles with Reformatsky reagent followed by Co(O‐Ac)2‐catalyzed reaction of the Blaise‐type intermediate with a second nitrile.
ChemInform Abstract: Fe+3‐Montmorillonite K‐10 as a Green and Reusable Catalyst for the Synthesis of New Generation of Dihydropyrimidinones
Authors: Nikpassand Mohammad , Fekri Leila Z. , Gharib Maryam , Marvi Omid
Published: April 2013

via a simple Biginelli protocol; 8 examples
ChemInform Abstract: Synthesis and Antibacterial Activity of New Diaryldiamines.
Authors: Samrin Farhana , Sharma Akash , Khan Inshad Ali , Puri Sadhna
Published: April 2013

Several new quinolones and quinazolines (V), (XIII), (XVIII) are synthesized from cheap and readily available starting materials.
ChemInform Abstract: Palladium Catalyzed One‐Pot Sequential Suzuki Cross‐Coupling—Direct C—H Functionalization of Imidazo[1,2‐a]pyrazines.
Authors: Gembus Vincent , Bonfanti Jean‐Francois , Querolle Olivier , Jubault Philippe , Levacher Vincent , Hoarau Christophe
Published: April 2013

The present new functionalization method of imidazo[1,2‐a]pyrazines proceeds selectively at C3 and C6 positions.
ChemInform Abstract: An Efficient Catalyst System for the Synthesis of N‐(p‐Benzoylaminoaryl)‐N′‐Boc Piperazines under Microwave Conditions.
Authors: Reddy Mule S. , Satyanarayana Peruri V. V. , Haribabu Bollikolla
Published: April 2013

The title compounds are synthesized by a new combination of a catalyst/ligand system under microwave conditions in short reaction times.
ChemInform Abstract: Divergent Synthesis of 2,6‐Diaryl‐Substituted 5,7,8‐Trimethyl‐1,4‐benzoxazines via Microwave‐Promoted Palladium‐Catalyzed Suzuki—Miyaura Cross Coupling and Biological Evaluation.
Authors: Koini Eftychia N. , Avlonitis Nicolaos , Martins‐Duarte Erica S. , de Souza Wanderley , Vommaro Rossiane C. , Calogeropoulou Theodora
Published: April 2013

Compounds (III) inhibit Toxoplasma gondii tachyzoite proliferation, exhibiting inhibition concentration values in the low micromolar range.
ChemInform Abstract: Boric Acid/Glycerol as an Efficient Catalyst for Synthesis of Thiomorpholine 1,1‐Dioxide by Double Michael Addition Reaction in Water.
Authors: Halimehjnai Azim Ziyaei , Hosseyni Seyedmorteza , Gholami Hadi , Hashemi Mohammed M.
Published: April 2013

The catalytic system is also successfully used for the Michael addition reaction of aromatic amines (II) to electron‐deficient alkenes (IV).
ChemInform Abstract: Synthesis of Antimalarial Trioxanes via Continuous Photo‐Oxidation with 1O2 in Supercritical CO2.
Authors: Hall Jessica F. B. , Bourne Richard A. , Han Xue , Earley James H. , Poliakoff Martyn , George Michael W.
Published: April 2013

The continuous photo‐oxidation of allylic alcohol (I) to its hydroperoxides (II) as a key step of the synthesis of antimalarial trioxanes such as (IV) is described.
ChemInform Abstract: Studies of Intramolecular Nitrone‐Alkene Cycloaddition Reaction: Regio‐ and Diastereoselective Synthesis of Chlorinated Isoxazolidines.
Authors: Roy Brindaban , De Rajendra Narayan
Published: April 2013

Readily available, stable nitrones (III) suffer an intramolecular cycloaddition in refluxing xylene furnishing chlorinated isoxazolidine derivatives (IV) in a regio‐ and diastereoselective fashion.
ChemInform Abstract: Cobalt‐Catalyzed Asymmetric 1,6‐Addition of (Triisopropylsilyl)acetylene to α,β,γ,δ‐Unsaturated Carbonyl Compounds.
Authors: Sawano Takahiro , Ashouri Akram , Nishimura Takahiro , Hayashi Tamio
Published: April 2013

A highly regio‐ and enantioselective 1,6‐addition is presented.
ChemInform Abstract: An Efficient Synthesis of Alkynyl Selenides and Tellurides from Terminal Acetylenes and Diorganyl Diselenides or Ditellurides Catalyzed by Recyclable Copper Oxide Nanopowder.
Authors: Godoi Marcelo , Ricardo Eduardo W. , Frizon Tiago E. , Rocha Manuela S. T. , Singh Devender , Paixao Marcio W. , Braga Antonio Luiz
Published: April 2013

The products are synthetically important compounds.
ChemInform Abstract: Regioselective Azidotrimethylsilylation of Carbohydrates and Applications Thereof.
Authors: Rao L Mallikharjuna , Yousuf Syed Khalid , Mukherjee Debaraj , Taneja Subhash Chandra
Published: April 2013

This method uses Mitsunobu conditions and trimethylsilyl azide to substitute primary alcohol moieties of carbohydrates with azide groups while secondary alcohol moieties are silylated.
ChemInform Abstract: The New Convenient Synthesis of Novel γ‐Alkylidenebutenolides from 6‐Aminopenicillanic Acid.
Authors: Yu Bin , Zhang En , Fang Yuan , Sun Xiao‐nan , Ren Jing‐li , Yu De‐quan , Liu Hong‐min
Published: April 2013

The methanolysis of azetidinone‐fused oxazoline (II) affords dipeptide (IV), which is readily converted into novel butenolide (V) and its 5‐substituted derivatives (VII)/(VIII).
ChemInform Abstract: Mixed Organotin(IV) Chalcogenides: From Molecules to Sn—S—Se Semiconducting Thin Films Deposited by Spin‐Coating.
Authors: Wagner Tomas , et al. et al.
Published: April 2013

Spin‐coating deposition of compound (IIIa) as a single‐source precursor provides amorphous Sn—S—Se semiconducting thin films.
ChemInform Abstract: The Road from Animal Electricity to Green Energy: Combining Experiment and Theory in Electrocatalysis
Authors: Greeley Jeffrey , Markovic Nenad M.
Published: April 2013

Review: 172 refs.
ChemInform Abstract: Creation of Next Generation Photoactive Materials
Authors: Emeline A. V. , Kuznetsov V. N. , Ryabchuk V. K. , Serpone N.
Published: April 2013

Review: 45 refs.
ChemInform Abstract: Main Challenges for High Performance NAS Battery: Materials and Interfaces
Authors: Wen Zhaoyin , Hu Yingying , Wu Xiangwei , Han Jinduo , Gu Zhonghua
Published: April 2013

Review: research progress and application of Na‐S batteries in large scale energy storge; 109 refs.
ChemInform Abstract: Solid‐State NMR: A Key Tool for the Understanding at a Molecular Level of Well‐defined Heterogeneous Catalysts
Authors: Gajan David , Lapadula Giuseppe , Schwarzwalder Martin , Coperet Christophe
Published: April 2013

Review: 35 refs.
ChemInform Abstract: Solid‐State NMR of Inorganic Semiconductors
Authors: Yesinowski James P.
Published: April 2013

Review: 380 refs.
ChemInform Abstract: Main Group Chemistry: Metal‐reinforced Bonding
Authors: Himmel Hans‐Joerg
Published: April 2013

Review: 11 refs.
ChemInform Abstract: N‐Alkylsulfonylimines as Dipolarophiles in Cycloaddition Reactions
Authors: Stubbing Louise A. , Savage G. Paul , Brimble Margaret A.
Published: April 2013

Review: 25 refs.
ChemInform Abstract: Carbonium Ions on the Surface of Acidic Catalysts
Authors: Anon. Anon.
Published: April 2013

Review: 113 refs.
ChemInform Abstract: Frontiers and Approaches to Chemical Synthesis of Oligodeoxyribonucleotides
Authors: Abramova Tatyana
Published: April 2013

Review: 72 refs.
ChemInform Abstract: Sesterterpenoids
Authors: Wang Lishu , Yang Bin , Lin Xiu‐Ping , Zhou Xue‐Feng , Liu Yonghong
Published: April 2013

Review: 166 refs.
ChemInform Abstract: Direct C—H Bond Arylations and Alkenylations with Phenol‐Derived Fluorine‐Free Electrophiles
Authors: Kozhushkov Sergei I. , Potukuchi Harish Kumar , Ackermann Lutz
Published: April 2013

Review: 126 refs.
ChemInform Abstract: Alternative Approaches for the Aqueous—Organic Biphasic Hydroformylation of Higher Alkenes
Authors: Obrecht Lorenz , Kamer Paul C. J. , Laan Wouter
Published: April 2013

Review: 107 refs.
ChemInform Abstract: Palladium‐Catalyzed Synthesis of Carbo‐ and Heterocycles Through Norbornene‐Mediated ortho C—H Functionalization
Authors: Ferraccioli Rafaella
Published: April 2013

Review: ca. 100 refs.
ChemInform Abstract: Laser‐Induced Femtosecond Magnetism
Authors: Zhang G. P. , George Thomas F.
Published: April 2013

Review: tutorial review; 29 refs.
ChemInform Abstract: High‐Field NMR. Sixty Years to Revolutionize Science
Authors: Zagdoun Alexandre , Emsley Lyndon
Published: April 2013

Review: 38 refs.
ChemInform Abstract: Natural Products as a Source of Antiherpes Simplex Virus Agents
Authors: Zhong Mei‐Gong , Xiang Yang‐Fei , Qiu Xian‐Xiu , Liu Zhong , Kitazato Kaio , Wang Yi‐Fei
Published: April 2013

Review: 147 refs.
ChemInform Abstract: Amino Acid and Peptide Bioconjugates
Authors: Mihala Nikolett , Hudecz Ferenc
Published: April 2013

Review: 234 refs.
ChemInform Abstract: Molecular Motors: A Turn in the Right Direction
Authors: Ernst Karl‐Heinz
Published: April 2013

Review: 9 refs.
ChemInform Abstract: Organic Stereochemistry. Part 1. Symmetry Elements and Operations, Classification of Stereoisomers
Authors: Testa Bernard , Vistoli Giulio , Pedretti Alessandro
Published: April 2013

Review: 56 refs.
ChemInform Abstract: A Quantitative Approach to Nucleophilic Organocatalysis
Authors: Mayr Herbert , Lakhdar Sami , Maji Biplab , Ofial Armin R.
Published: April 2013

Review: 114 refs.
Fluorine Substitution Effects on Flexibility and Tunneling Pathways: The Rotational Spectrum of 2‐Fluorobenzylamine
Authors: Calabrese Camilla , Maris Assimo , Evangelisti Luca , Caminati Walther , Melandri Sonia
Published: April 2013

The effect of ring fluorination on the structural and dynamical properties of the flexible model molecule 2‐fluorobenzylamine has been studied by rotational spectroscopy in free‐jet expansion and quantum chemical methods. The complete potential energy surface originating from the flexibility of the aminic side chain has been calculated at the B3LYP/6‐311++G** level of theory and the stable geometries were also characterized with MP2/6‐311++G**. The rotational spectra show the presence of two of the predicted four stable conformers: the global minimum (I), in which the side chain’s dihedral angle with the phenyl plane is almost perpendicular, is stabilized by an intramolecular hydrogen bond between the fluorine atom and one hydrogen of the aminic group; and a second conformer II (EII−EI≈5 kJ mol−1) in which the dihedral angle is smaller and the amino group points towards the aromatic ortho hydrogen atom. This conformation is characterized by a tunneling motion between two equivalent positions of the amino group with respect to the phenyl plane, which splits the rotational transition. The ortho fluorination increases, with respect to benzylamine, the tunneling splitting of this motion by four orders of magnitude. The motion is analyzed with a one‐dimensional flexible model, which allows estimation of the energy barrier for the transition state as approximately 8.0 kJ mol−1.
Water‐Soluble Palladium Click Chelating Complex: An Efficient and Reusable Precatalyst for Suzuki–Miyaura and Hiyama Reactions in Water
Authors: Kong Fanzhen , Zhou Chunshan , Wang Jinyun , Yu Zhangyu , Wang Ruihu
Published: April 2013

A water‐soluble ionic palladium(II) nitrogen‐containing chelating complex, [palladium(II) 1‐(4‐N,N′,N′′‐trimethylbutylammonium)‐4‐(2‐pyridyl)‐1H‐1,2,3‐triazole dichloride] chloride (3), was prepared through the click reaction of 1‐chloro‐4‐bromobutane, sodium azide, and 2‐ethynylpyridine, followed by the quarternization of Me3N and subsequent reaction with [Pd(cod)Cl2] (cod=1,5‐cyclooctadiene). The catalytic performances of complex 3 were preliminarily evaluated through Suzuki–Miyaura and Hiyama cross‐coupling reactions of aryl bromides; excellent catalytic activity in water was observed. TEM analysis revealed that small palladium nanoparticles (NPs) with a narrow size distribution were formed after the catalytic reaction. The NPs were stabilized by the synergetic effect of coordination and electrostatic interactions from the ionic, bidentate, nitrogen‐containing ligand; no palladium black was detected after the aqueous solution of palladium NPs was stored in air for months. The use of 3 as a precursor in the formation of palladium NPs was further explored by using NaBH4 and hydrogen as reductive reagents. The resulting NPs displayed different sizes, surface properties, and catalytic performances in the Suzuki–Miyaura cross‐coupling reaction in water.