bluuebunny/crossref_metadata_2025 huggingface dataset:
Implementation of Global Academic Record and Verification System Against Credential Fraud
Authors: Berrios Moya Juan Alamiro , Ayoade John
Published: November 2024

Academic credential fraud poses a real challenge to the global academic and labour market. Fraudulent credentials devalue the legitimacy of bona fide certificates. The Global Academic Record and Verification based on Blockchain and Interplanetary File Systems (GARV-BI) framework was implemented and offers a holistic, privacy-preserving, immutable, secure, and interoperable system for managing academic records. Using advanced blockchain technology, it proposes zkEVM for smart contracts that enables verification of credentials without exposing the underlying data. It also integrates the use of Decentralized IDentifiers (DID) to standardize registration and identity management without relying on centralized entities. A key feature of GARV-BI is that it features a dual blockchain, which separates public and private information, allowing for greater efficiency and privacy of transactions. It also uses the interplanetary File System (IPFS), which allows for decentralized and secure storage of related documents. The result is an open-source solution that is easily integrated, as it uses a standardized Application Programming Interface (API). Extensive testing has shown that it can successfully manage transactions securely, privately, and at a lower cost than solutions based on Ethereum mainnet environments.
GARV-BI is innovative in its combination of blockchain technologies, decentralized storage, and globally unique identifiers to achieve higher levels of interoperability, security, and privacy. GARV-BI will transform academic credential management with a platform that is accessible, adaptable, and robust for use by institutions around the world to maintain the integrity of academic qualifications and enable global student mobility.
Rectangular Improvement Method for Plan View Pattern of Plate During Angular Rolling Process
Authors: He Chunyu , Luo Junyi , Xu Zhipeng , Wang Zhiqiang , Zhao Zhong , Wu Zhiqiang , Jiao Zhijie
Published: November 2024

The effect of the angular rolling process on the plan view pattern of the plate is studied, the rectangular influence factor and improvement method for plate angular rolling process are proposed in this paper. Finite element models are established for the conventional rolling and angular rolling processes respectively, and with DEFORM software, the numerical simulation is carried out. A characterization formula reflecting the rectangular degree of the rolled piece is constructed and the rectangular degree of the plates under different rolling process conditions are compared. Considering the actual rolling process conditions, the range of theoretically calculated rectangular rotation angles is extended to obtain the optimum rectangular rotation angle with finite element simulation method. The one-group two-pass angular rolling is separated to one-group four-pass rolling and the simulation results show that the rectangular degree of the four-pass process is better than the two-pass process. Angular rolling experiments are carried out, the actual data shows that the rectangular characteristic value of the rolled piece is 1.003 with the four-pass process, and 1.014 with the two-pass process. It verifies that with separating one-group two-pass angular rolling process to one-group four-pass angular rolling process can improve the rectangular degree of the rolled plate.
Scaling of Rotational Constants
Authors: Tikhonov Denis S. , Sueyoshi Colin J. , Sun Wenhao , Xie Fan , Khon Maria , Gougoula Eva , Li Jiayi , Berggötz Freya , Singh Himanshi , Tonauer Christina M. , Schnell Melanie
Published: November 2024

This manuscript introduces the concept of scaling factors for rotational constants. These factors are designed to bring computed equilibrium rotational constants closer to experimentally-fitted ground-state-averaged rotational constants. The parameterization of the scaling factors was performed for several levels of theory, namely DF-Dn/def2-mVP (DF=B3LYP,PBE0, n=3(BJ),4, m=S,TZ), PBEh-3c, and r2SCAN-3c. The obtained scaling factors systematically improve the consistency between theoretical and experimental rotational constants.
Economic Efficacy: Exploring Decision-Making In Islamic School Budgeting For Enhanced Resource Allocation
Authors: Djoko Susanto Teguh Trianung , Maryati Sri , Wulandari Adi , Goentomo Stevanni Reynita , Ramadhania Andita Putri
Published: November 2024

Making the right decisions in determining Islamic School budgets is a key element to secure the efficiency and sustainability of the education system. The purpose of this study is Economic Efficacy: Exploring Decision-Making in Islamic School Budgeting for Enhanced Resource Allocation. This research method is based on a qualitative approach that allows researchers to understand in depth the context of decision making in Islamic School budgeting. The results of this study show that decision making in Islamic School budgeting plays a key role in the economic effectiveness of education resource allocation. Several key findings highlight the complexity and variety of factors influencing the decision-making process, including education priorities, government policies, and pressure from stakeholders. The results of this study show that Data analysis and the use of accurate information have proven essential in ensuring effective decision making. Islamic Schools that use solid data to evaluate student performance and the effectiveness of educational programs tend to make better decisions in budget allocation
Developing An E-Learning Platform For Islamic Education That Incorporates The Principles Of Religious Moderation Within School Settings
Authors: Anam Saeful , Mubin Nur
Published: November 2024

The establishment of online Islamic religious e-learning with a focus on religious moderation in educational institutions is an endeavor aimed at broadening the availability of well-rounded and balanced Islamic religious education through digital learning platforms. This research aimed to create an e-learning system that specifically emphasizes the principles of religious moderation within schools. The research adopted a developmental approach (R&D), by utilizing the ADDIE model (Analysis, Design, Development, Implementation, and Evaluation). After conducting an analysis, the e-learning system was designed and developed using cutting-edge technology that enables active student interaction and engagement. Subsequently, the e-learning system was introduced as a pilot project in the school setting. Students and teachers actively participated in utilizing this system to access Islamic religious content that was customized to their individual needs and comprehension level. Throughout the implementation phase, an assessment was conducted to evaluate the effectiveness of the e-learning system in enhancing comprehension of the Islamic faith and fostering a moderate religious mindset. The findings of this research demonstrated a significant demand for Islamic religious education focused on religious moderation. There was a pressing need for the development of efficient learning tools to facilitate successful comprehension of Islamic Studies materials, particularly among junior high school students. This conclusion is supported by the analysis of data using the Wilcoxon test, which yielded a t-value of -4.878 and a p-value of 0.00, indicating statistical significance (p < 0.05).
The Development of Hadith Study in Islamic Boarding Schools and Islamic Higher Education in Indonesia
Authors: Yuliharti Yuliharti , Rahman Rahman , Nafisah Lailiyatun , Ridwan Wawan Ahmad , Ali Akbar Muhammad Yudi , Alfiah Alfiah , Nurhaidah Siti Nuri
Published: November 2024

The study of hadith as a source of Islamic teachings after the Qur’an is an important part of Islamic studies in Indonesia, both in Islamic boarding schools (pesantren) and Islamic higher education. The study of hadith at these two Islamic educational institutions has a different style. Hadith studies in pesantren are more focused on understanding the content of text (matan) of hadith by studying the traditions contained in the books of Riyad al-Salihin, Sahih al-Bukhori, Sahih Muslim and other books. Meanwhile, the study of hadith in Islamic higher education has experienced rapid development by focusing on the study of methodological mastery, for example, sanad and matan research methodologies. The books that are used as references are also more varied, such as the book of the tarikh al-ruwat, al-jarh wa al-ta'dil, rijal al-hadith, and other contemporary hadith books. This study aims to comprehensively reveal the development of hadith studies in these two Islamic educational institutions. This type of research is field research (field research). The data were collected by conducting a direct search in the field through the methods of interview, observation, and documentation. The data collected were analyzed and presented in a qualitative descriptive manner using a phenomenological approach. The research found that the study of hadith in Islamic boarding schools and Islamic higher education had different tendencies. These two tendencies need to be mapped so that they can be used as a model in comprehensively studying the Prophet's hadith.
A definição e a identificação do comentário metadiscursivo sob uma perspectiva interacionista
Authors: Braga Paloma Bernardino , Martins de Brito Daniel
Published: November 2024

Este trabalho busca oferecer um percurso para a definição e a identificação da relação de discurso comentário metadiscursivo através de uma abordagem interacionista, o Modelo de Análise Modular do Discurso (Roulet; Filliettaz; Grobet, 2001). Verificamos que o termo é utilizado, muitas vezes, sem precisão teórica e sem critérios explícitos de identificação. Assim, propomos um caminho para um tratamento mais seguro acerca do comentário metadiscursivo. Para isso, com base em informações linguísticas, textuais e referenciais, apresentamos alguns critérios para a compreensão e identificação de relações de comentário em diversos textos. Em seguida, o estudo mostra, por meio de procedimentos baseados em critérios relacionais e enunciativos, o processo de análise e identificação do comentário metadiscursivo em debate eleitoral presidencial.
RETRACTED: Numerical study on the Behavior of High Strength Concrete Encased Steel (CES) Composite Stub Columns under Compressive Load
Authors: Said Shwan H. , Khalel Raid I. , Hasan Kamalaldin F.
Published: November 2024

The authors have requested that this preprint be removed from Research Square.
RP-HPLC Method Development and Validation of Abacavir, Lamivudine and Zidovudine in combined pharmaceutical dosage by Analytical QbD
Authors: Vanparia Divyesh , Dedania Ronak , Dedania Zarna
Published: November 2024

The assessment of three antiviral medications, namely Abacavir (ABA), Lamivudine (LAMI), and Zidovudine (ZIDO) in combined pharmaceutical dosage form was accomplished by the development and validation of a high-performance liquid chromatographic technique. Using the Box-Behnken Design and the Design Expert® software (Version 11.0), the Analytical Quality by Design (AQbD) RP-HPLC method was created for the simultaneous quantification of drugs. The ideal circumstances for the composition of the mobile phase Methanol, Acetonitrile and Potassium dihydrogen phosphate (pH 3.5) 65:20:15% v/v/v on Shimadzu C18 column on an HPLC system with UV detection at 280 nm was used and a flow rate of 1.0 mL/min. It was discovered that the retention times (min) for ABA, LAMI, and ZIDO were 4.12, 6.71, and 9.25, in that order. Both the asymmetry factor and the number of theoretical plates fall within the bound. The ICH guideline was followed in the validation of the suggested approach. It was discovered that the linearity was 10–60 µg/mL ZIDO, 5–30 µg/mL LAMI, and 10–60 µg/mL ABA. Three stages of the recovery study were 50%, 100%, and 150%. With intentional parameter adjustments, the method's % RSD of peak area was less than 2%, demonstrating its robustness. The medication mixture assay shows no signs of excipient interference.
The AXL-Mediated Modulation of Myeloid-Derived Suppressor Cells (MDSC) in Nasopharyngeal Carcinoma
Authors: Lv Yu , Zhu Jiahui , Ge Sichen , Jiang Tao , Xu Yajia , Yao Weige , Jiang Chengyi
Published: November 2024

AXL has ubiquitous expression in multiple cancers, and is strongly linked to both tumor progression, metastasis, and poor prognosis, as well as anti-tumor immune response suppression and induction of tumor resistance to immunotherapy. Therefore, it is a strong target for cancer intervention. Despite the wide application of AXL inhibitors in clinical trials, the role of AXL in the tumor immune microenvironment (TIME) remains undetermined. Herein, we established cell lines with stable AXL knockdown or overexpression using lentiviral infection. Subsequently, we co-cultured the cells with healthy human blood-derived CD33 + PBMCs. After two days in culture, we assessed the PBMCs differentiation into MDSCs and determined the IL-6 and GM-CSF contents in the co-culture supernatants. Additionally, we subcutaneously administered nasopharyngeal carcinoma (NPC) cells into mice, and evaluated the association between AXL content and MDSC aggregation in the resulting tumors. We demonstrated that AXL is a critical modulator of MDSC differentiation and accumulation in NPC. It modulates IL-6, GM-CSF, and Toll-like receptor contents to achieve the aforementioned actions. Herein, we revealed a strong and direct link between AXL, cytokines in TIME, and MDSC differentiation and accumulation. Our work highlights novel approaches to optimizing existing immunotherapeutic interventions.
Aramid Nanofibers at Ultralow Loadings: Driving Significant Multifunctionality in Epoxy Composite Dielectrics
Authors: Yuan Hao-Wen , Wang Zi , Zang Zicheng , Wu Qing-Zhou , Jiang Guoqing , Wei Hua-Chao , Zhang Yi-Yi , Zheng Jiajia , Ren Jun-Wen , Wu Guanglei , Jia Shen-Li
Published: November 2024

Epoxy materials with superior dielectric, mechanical, and thermal performance are of great interesting for electrical equipment and power electronics. However, integrating these excellent advantages into epoxy materials presents a formidable challenge. Herein, we detail a simple yet effective strategy for the concurrent enhancement of the dielectric breakdown strength, mechanical toughness, and mechanical strength of the epoxy materials by incorporation of a minimal amount of aramid nanofibers (ANFs). It is revealed that a robust interfacial interaction is established between epoxy matrix and the high aspect ratio of ANFs as corroborated by both molecular dynamics simulations and dielectric relaxation spectroscopy. The strong interaction facilitates an optimized interface that enables efficient transfer of interfacial stress and energy dissipation, in turn conferring the ANFs/Epoxy with exceptional mechanical toughness and strength of 75.68 MPa and 195 MJ/m3, respectively. Furthermore, the incorporation of ANFs introduces a multitude of deep traps which effectively impede the migration of charge carriers, contributing to a substantial improvement of the dielectric breakdown strength of the ANFs/Epoxy composite, which is elevated to 196.8 kV/mm. The versatility, exceptional electrical insulating, and scalability of ANFs/Epoxy showcase its immense potential for advanced electronics and electric power systems, especially for withstanding extra/ultra high voltage applications.
Slotting blasting model experiment and PCA-PNN evaluation model of influencing factors of slitting effect
Authors: Li Qiang , Sun Jinshan , Wang Cunguo , Wang Jianguo , Wang Xinguo , Yan Aiguo
Published: November 2024

Numerous parameters influence the slotting performance of slotted cartridge; however, the extent of influence of each parameter is not well understood. To facilitate rapid, efficient, and accurate predictions of the slotting performance, several evaluation indicators generally need to be considered. Nevertheless, these indicators frequently exhibit correlations, resulting in overlapping information. A statistical analysis of blasting experiments conducted on PMMA with six different slotted cartridge parameters yielded 12 indicators for assessing the slitting performance. Subsequently, a principal component analysis (PCA) method was introduced to reduce the dimensionality of the data associated with these indicators, and three new comprehensive indicators were extracted for a comprehensive assessment of the slotting performance. The PCA scores ranked the influence of the six slotted cartridge parameters on slotting performance as follows: decoupling coefficient, slotting width, slotting angle, slotting tube thickness, slotting tube material, and charge amount. This ranking serves as a guideline for selecting suitable slotted cartridge parameters. On the basis of the PCA, a probabilistic neural network (PNN) model was developed to assess slotting performance levels. The predictive results demonstrated that the PCA-PNN model performed well across eight different training and testing sample configurations, achieving correct prediction rates of 100%, 100%, 96.43%, 89.29%, 89.29%, 89.29%, 78.57%, and 78.57%, respectively. This corresponded to an average accuracy improvement of 11.61% compared to data that was not subjected to PCA dimensionality reduction. Moreover, the PCA-PNN model was validated as a robust and feasible approach for evaluating the slotting performance of slotted cartridge.
Urological management in people with traumatic and non-traumatic spinal cord injury in Brazil
Authors: Martins Giovana Pelosi , Corbo Letícia Noelle , Lopes Filipe , Ferreira Eliz , de Souza Daniel Rubio , Tate Denise Galuf , Faleiros Fabiana
Published: November 2024

Study desing: Despite the critical need for data to support public health policies in Brazil, there is a glaring lack of national epidemiological studies on neurogenic lower urinary tract dysfunction (NLUTD).
Objectives: This study aimed to illuminate the factors associated with the urological management of NLUTD among individuals with traumatic spinal cord injury (TSCI) and non-traumatic spinal cord injury (NTSCI).
Methods: Employing a quantitative, cross-sectional, and descriptive design, this study analyzed electronic medical records of NLUTD and SCI patients monitored within the SARAH network from 2007 to 2017. Sociodemographic and clinical data were collected, including the ASIA Impairment Scale, and statistical analyses such as the Mann-Whitney and Pearson's Chi-square tests were conducted.
Results: The findings revealed that out of 903 patients, 67% had TSCI and 33% had NTSCI. Clean intermittent catheterization (CIC) was the primary bladder emptying method, utilized by 66.11% of the participants. The average emptying frequency was 4.71 times a day, and urinary incontinence was reported in 58.4% of cases. A significantly higher rate of positive urinary colonization was found among TSCI patients.
Conclusions: The study highlighted significant differences in NLUTD management between TSCI and NTSCI patients, with NTSCI patients more frequently achieving voluntary urination and using maneuvers to stimulate urination. These distinctions underscore the need for more individualized approaches and deeper understanding of each type of spinal cord injury, aiming to enhance bladder rehabilitation programs in Brazil.
The Effects and Durability of 8 weeks of Dynamic Neuromuscular Stabilization Exercises on Balance and Neuromuscular Coordination of Adults with Intellectual Disabilities
Authors: Babagoltabar-Samakoush Hamed , Aminikhah Behnoosh , Bahiraei Saeid
Published: November 2024

Background
Individuals with intellectual disabilities (IDs) often exhibit
lower levels of physical fitness compared to the general
population, including reduced balance and neuromuscular
coordination. Dynamic neuromuscular stabilization (DNS) training
has been proposed as a potential intervention to improve physical
fitness in this population, but the effectiveness and durability of
DNS training on specific fitness components have not been
well-established. Therefore, the aim of the present study was to
investigate the effects and durability of 8 weeks of DNS exercises
on the balance and coordination of adults with IDs.

Methods
A total of 31 participants were randomly assigned to either an
intervention group (n = 16) or a control group (n = 15). Balance
and neuromuscular coordination were assessed at baseline,
immediately after the intervention, and 2 months following the
intervention using the Balance Error Scoring System test, walking
forward heel-to-toe test, and bilateral coordination test.
Participants in the intervention group engaged in the DNS training
program for 8 weeks, with 3 sessions per week, while the control
group maintained their usual activities.

Results
The analysis of the outcome measures revealed significant time,
group, and time-group interaction effects. Post-hoc analyses
indicated that the DNS group exhibited significantly greater
improvements in BESS scores and coordination compared to the
control group (p < 0.01). These improvements were maintained at
the 2-month follow-up assessment in the DNS group.

Conclusion
In general, it seems that the DNS exercises could improve
balance, and neuromuscular coordination of middle-aged people with
IDs ities, and the gained improvements were still existing after 8
weeks.
Adverse events in the nervous system associated with blinatumomab: A real-world study
Authors: Gao Wen , Yu Jingwei , Sun Yifei , Song Zheng , Liu Xia , Han Xue , Li Lanfan , Qiu Lihua , Zhou Shiyong , Qian Zhengzi , Wang Xianhuo , Zhang Huilai
Published: November 2024

Background
Nervous system toxicity (NST) is frequent and dangerous adverse events of blinatumomab, which is the first bispecific antibody drug targeting CD19 and CD3. Current data from clinical trials do not fully reflect the real-world situation. This study aimed to evaluate the NST of blinatumomab in real-word.
Methods
Data were retrieved from the FAERS. The reporting odds ratio (ROR), proportional reporting ratio (PRR), Bayesian confidence interval progressive neural network (BCPNN), and multi-item gamma Poisson shrinker (MGPS) algorithms were used for data mining.
Results
A total of 5,962 cases involving blinatumomab were extracted. NST occurred more frequently in male (40.19%) and was prevalent among young (18–45 years, 20.21%) and the United States patients (58.60%). Forty-three signals of NST were identified, of which neurotoxicity, neurological symptoms, agnosia, intention tremor, and immune effector cell-associated neurotoxicity syndrome had the highest ROR values. Concomitant use of medication for age, musculoskeletal system, genitourinary system and sexual hormones were independent risk factors for NST, and age was an independent protective factor for fatal NST. For neurological events, the median time to onset (TTO) was 3 days (range, 1 ~ 17). The highest fatality rate for neurological events was observed for increased intracranial pressure disorders, which also had the highest co-occurrence rate with cytokine release syndrome (CRS).
Conclusions
Age is an independent protective factor for fatal NST and CRS leads to a higher fatality rate for NST patients treated with blinatumomab. Thorough medication evaluation should be conducted before administering blinatumomab, especially for high-risk patients with preexisting neurological conditions.
Development and validation of a nomogram for predicting postoperative pulmonary complications in older patients undergoing noncardiac thoracic surgery: a prospective, bicentric cohort study
Authors: Zhou Yongxin , Wang Haiyan , Lu Dianyu , Jiang Tao , Huang Zhanpeng , Wang Feixiang , Yao Yonghua , Gu Yu , Wei Wei
Published: November 2024

Background The ARISCAT score, a prospectively developed generic classification for postoperative pulmonary complications (PPCs), has shown excellent predictive performance in general surgery. However, there is no reliable classification instrument for PPCs prediciton in thoracic surgery.
Objective This study aimed to develop and validate a novel nomogram for estimating the risk of pulmonary complications in older patients (≥ 65 years) within 30 days after NCTS.
Methods A nomogram was developed using predefined candidate predictors of 30-day PPCs. It was fitted with least absolute shrinkage and selection operator and logistic regression methods. Internal validation was performed using a bootstrap-resampling approach, while external validation used an independent, temporally separated cohort. The model’s performance was assessed based on its discriminative potential (area under the receiver operating characteristic curve [AUC]), predictive ability (calibration plots), and clinical utility (net benefit).
Results In the development (n = 1449) and validation (n = 449) cohorts, 34.9% and 31.4% of patients, respectively, developed pulmonary complications 30 days post-surgery. The final nomogram incorporated eight predictors (age, surgical approach, desaturation of < 92% for more than 2 min, duration of surgery, smoking status, FEV1/FVC%, respiratory infection in the last 30 days, and neoadjuvant chemotherapy). The nomogram showed excellent discrimination (AUC = 0.866, 95% confidence interval [CI], 0.846–0.885), calibration (Hosmer- Lemeshow test, P = 0.97) and overall performance (Brier score = 0.014) in the development cohort. Similar results were observed in the external validation cohort (AUC = 0.825, 95% CI, 0.786–0.864). A decision curve analysis indicated that the nomogram offers a positive net benefit compared with the ARISCAT and LAS VEGAS scores.
Conclusions This novel nomogram can reliably identify older patients with a high risk for pulmonary complications within 30 days after NCTS.
Trial registration ChiCTR2100051170.
Multi-centre retrospective study compared the outcomes of laparoscopic and open gastric resection for gastric cancer
Authors: Saad Hassan A. , Baz Azza , Riad Mohamed , Eraky Mohamed E , Farid Mohamed I , Said Huda EM , Elgammal Eid Rizk , Harira Mervat , Yousef Ahmed El-Sayed
Published: November 2024

The use of minimally invasive techniques has not attained the same widespread acceptance for the treatment of more advanced tumors, principally because of existing concerns about its feasibility and oncological adequacy.
Laparoscopy is rarely used to treat stomach malignancy. We compared the outcomes of laparoscopic gastrectomy with those of open surgery, and results evaluated .
There is still a debate regarding whether one of these options is superior. We need to compare the primary and secondary outcomesof laparoscopic versus open gastrectomy in patients with locallyadvanced gastric cancer, therefore, complete acceptance as a legitimate therapy is hampered by the lack of thorough investigation of long-term oncological consequences, including recurrence and fatality.
Methods
We retrospectively evaluated patients who underwent laparoscopic or open gastrectomy between February 2015 and November 2022. After collecting the database from the board sheet of our Zagzig University Hospital and six other specialist surgical hospitals, patients were divided into two groups: open surgery and laparoscopic surgery. Logistic regression was used to compare the 30-day complications and fatalities in both groups.
Results
The Risk ratio (RR) and 95% confidence interval (CI) were calculated. For consistent results, the mean difference (MD) or standardized mean difference (SMD) and 95% confidence interval (CI) were calculated. The meta-analysis was conducted using Review Manager 5.3 and STATA software. A total of 8,232 gastric cancer patients were divided into two groups based on the type of surgery they underwent: open gastrectomy (n= 7,450; 90.5%) and laparoscopic surgery (n = 782; 9.5%). Preoperative measurement of risk variables was important (CI = 0.45-0.82, p = 0.001, odds ratio [OR] 0.61, 95% confidence interval). We found no significant differences in mortality between groups when the preoperative risk variable was measured (OR = 0.74; 95% CI = 0.32-1.72; p = 0.481).
Readmission of patients with hypertriglyceridemia-induced acute pancreatitis: A prospective cohort study
Authors: Liu Yuxiang , Ding Ling , Xu Xin , Guan Langyi , He Wenhua , Xia Liang , Lu Nonghua , Zhu Yin
Published: November 2024

Background
Acute pancreatitis (AP) is a common cause of acute hospital admissions in digestive system diseases. In East Asia, hypertriglyceridemia is gradually emerged as the second most common cause of pancreatitis. Vigilance for recurrence and unplanned readmissions due to other causes is still necessary after discharge. studies on hypertriglyceridemia-induced acute pancreatitis (HTG-AP) are scarce and mainly consists of retrospective studies.
Methods
This was a prospective cohort study of adult patients with first episode of HTG-AP from December 2019 to February 2021 who were followed up for two years. Unscheduled readmission after the index discharge was the primary outcome. The Cox proportional-hazards model, and the Fine and Gray's competing-risk model were applied to the analyses.
Results
Totally, 293 survival patients were followed-up after discharge. The overall unplanned readmission rate was 30.0% in two years. Among them, 60 (20.5%) patients were readmitted to hospital once, 16 (5.5%) were readmitted twice, and 13 (4.4%) were readmitted three times or more. In summary, a total of 143 cases of readmission information were collected during the follow-up period. The recurrence accounts for a significant 77.3% proportion and stands as the primary cause for readmission. Cox regression model favors infection (Hazard ratio [HR], 3.066; 95% confidence interval [CI], 1.192-7.888; P = 0.02) and age lower than 41.5 years old (HR, 3.157; 95% CI 1.883-5.292; P<0.01) as independent risk factors for patient readmission by multivariate analysis. The competing-risk model support the similar results compared with the former.
Conclusion
Unplanned readmission of patients with hypertriglyceridemia-induced acute pancreatitis is common, especially for young patients with occurrence of any infection during hospitalization, and warrant further investigation.
Trial registration
The study was registered at https://www.chictr.org.cn (ChiCTR1900028594) and was performed in accordance with the Declaration of Helsinki principles.
Epigenetic Aging and Risk of Obstructive Sleep Apnea: a bidirectional Mendelian randomization study
Authors: Xu Chenyi , Yang Gang , Liu Yuehua
Published: November 2024

Background
Obstructive Sleep apnea (OSA) is a prevalent sleep disorder characterized by repetitive interruptions of breathing during sleep, significantly impacting cardiovascular and metabolic health. Epigenetic aging, measured via DNA methylation-based clocks, has emerged as a robust predictor of biological aging and associated health outcomes. This study investigates the causal relationship between epigenetic aging and the risk of sleep apnea using a bidirectional Mendelian randomization (MR) approach.
Methods
We utilized genome-wide association study (GWAS) summary statistics for epigenetic aging markers (HannumAge, HorvathAge, PhenoAge, and GrimAge) and sleep apnea from FinnGen. Instrumental variables were selected based on stringent criteria to ensure validity. The causal association was assessed using inverse variance weighted (IVW), weighted median (WM), and MR-Egger methods. Sensitivity analyses, including heterogeneity and pleiotropy assessments, were conducted to validate the robustness of the findings.
Results
In this study, using Mendelian randomization analysis, we investigated the relationship between epigenetic age acceleration markers HannumAge, HorvathAge, PhenoAge, and GrimAge, and the risk of obstructive sleep apnea (OSA). The results showed that these markers of epigenetic age acceleration were not significantly associated with an increased risk of OSA. Quality control assessments confirmed the reliability of our findings. Although previous literature suggests an association between epigenetic age acceleration and sleep apnea, our study did not support a causal relationship between the two. This finding provides a new perspective on the relationship between epigenetic age acceleration and OSA, highlighting the need for further research.
Conclusion
The current Mendelian randomization analysis revealed no causal relationship between epigenetic clocks and obstructive sleep apnea (OSA). However, the potential for a shared genetic architecture should be considered. Conducting a comorbidity genetic analysis may provide further insights into this relationship.
Gentrification, measures of neighborhood change, and infant mortality in Michigan
Authors: Murosko Daria , Passarella Molly , Montoya-Williams Diana , Mehdipanah Roshanak , Lorch Scott
Published: November 2024

Infant mortality (IM), or death prior to the first birthday, is a key public health metric that increases with neighborhood structural inequities. However, neighborhood exposures shift as communities undergo gentrification, a pattern of neighborhood change defined by increasing affluence (in wealth, education, and housing costs). Gentrification has inconsistent associations with infant health outcomes like IM, which may be due to differing relationships between its composite measures and such outcomes. We designed a retrospective cohort analysis of all births and deaths from 2010–2019 across 4 metropolitan areas in Michigan to determine how gentrification and its neighborhood-change components are associated with risk of IM, using multilevel multivariable logistic regression models. Among 672,432 infants, 0.52% died before 1 year. IM was not associated with gentrification overall. However, in unadjusted models, odds of IM were 40% and 15% lower for infants living in tracts in the top quartile increase in household income and college completion, respectively, compared to infants from tracts with the least amount of change. Odds of IM were conversely increased 29% in infants from tracts with the most increases in rent, though these differences were attenuated when adjusting for individual social factors. Indicators of increasing community affluence, which are often combined to define gentrification, have opposing relationships with IM. Policies and interventions that address rising housing costs may reduce IM.
Role of Soil Fungal Communities in Root Decomposition Across Various Root Orders in Temperate Forest Plantations
Authors: Gao Yang , Pan Li , Zhao Dehai , Sun Tao , Wang Xiuwei
Published: November 2024

Background and Aims: Root decomposition is pivotal for nutrient cycling and energy flow in forest ecosystems, yet the comprehensive understanding of this process, particularly concerning root order, remains elusive.
Methods:Our three-year experimental study explores root decomposition dynamics of four prevalent tree species in northeastern China under the influence of global warming trends. Utilizing spatial variation, we investigate how native and non-native root decompose across different sites.
Results: Our findings reveal that root decomposition rates vary significantly with site, tree species, and litter source. Notably, decomposition rates decreased with increasing latitude, with slower rates observed at specific root levels regardless of climate or microbial influence. Furthermore, the composition and abundance of ectomycorrhizal fungi, saprotrophs, and pathotrophs in the soil play a crucial role in root litter decomposition, particularly influencing the mass remining in mid-order roots.
Conclusion: Our study sheds light on order-based root decomposition dynamics and enhances understanding of carbon dynamics in perennial plantation-dominated soil ecosystems.
Deriving non-perturbative gravity dual of quantum Liouville theory from BCFT operator algebra
Authors: Hung Ling-Yan , Chen Lin , Jiang Yikun , Lao Bingxin
Published: November 2024

We demonstrate that, by utilizing the boundary conformal field theory (BCFT) operator algebra of the Liouville CFT, one can express its path-integral on any Riemann surface as a three dimensional path-integral with appropriate boundary conditions, generalising the recipe for rational CFTs. This serves as a constructive method for deriving the quantum holographic dual of the CFT, which reduces to Einstein gravity in the large central charge limit. As a byproduct, the framework provides an explicit discrete state-sum of a 3D non-chiral topological theory constructed from quantum 6j symbols of $\mathcal{U}_q(SL(2,\mathbb{R}))$ with non-trivial boundary conditions, representing a long-sought non-perturbative discrete formulation of 3D pure gravity with negative cosmological constant, at least within a class of three manifolds. This constitutes the first example of an exact holographic tensor network that reproduces a known irrational CFT with a precise quantum gravitational interpretation.
PACS numbers: 11.15.-q, 71.10.-w, 05.30.Pr, 71.10.Hf, 02.10.Kn, 02.20.Uw
Effects of the Conditional Cash Transfer Program on Poverty and Income Distribution in the Dominican Republic
Authors: Vásquez Harold , Pellerano José , Rosa Daniel De la
Published: November 2024

This study assesses the impact of the Dominican Republic?s PROSOLI cash transfer program on poverty and inequality from 2005 to 2019, offering insights into the program?s role in reducing poverty. Using simulations based on administrative data, we find that PROSOLI reduces overall poverty by an average of 0.83 percentage points, with notable declines in extreme poverty, particularly under optimized beneficiary targeting. Our results highlight the advantage of leveraging administrative data over self-reported survey data, improving the precision of poverty measures and program evaluations. We simulate various scenarios, comparing the impact with potential outcomes from alternative beneficiaries and benefit allocations. This approach provides a unique perspective, demonstrating how administrative data can significantly enhance the effectiveness of social programs by offering a more accurate assessment of their impact. Our findings underscore the potential of evidence-based policymaking to address poverty and inequality challenges more effectively. Overall, this paper contributes to the literature on cash transfer programs by presenting a method that refines poverty measurements and highlights the broader socioeconomic benefits of such initiatives, offering valuable insights for policymakers aiming to optimize social assistance programs.
JEL Classification: C54 , D63 , I38
Daily range sizes correlate positively with resting metabolic rate in bush Karoo rats (Otomys unisulcatus)
Authors: QIU Jingyu , Makuya Lindelani
Published: November 2024

Home range size limits the number of resources an individual can access; hence, it often increases with energy demands. However, maintaining a large home range also requires more energy expenditure, and foraging over a larger area can decrease search efficiency, especially for central place foragers that travel frequently between a home base and food patches. Consequently, individuals may need to reduce energy expenditure in other aspects, such as resting metabolic rate (RMR). So far, studies examining the relationship between home range size and RMR are limited. In this study, we investigated whether RMR is correlated with home range size in bush Karoo rats (Otomys unisulcatus). Using the Foxbox and mini-GPS dataloggers, we measured body mass, RMR (scaled by body mass), and daily home ranges of 25 female adult bush Karoo rats in the field. As commonly found in home range studies, body mass was associated with range size in bush Karoo rats. In addition, body mass-scaled RMR was positively associated with home range size. This suggests that a larger home range provides sufficient energy to support the increased energy expenditure required for foraging, as well as a higher energy budget for basal biological processes in female bush Karoo rats.
Financial Development and Economic Growth: A Case of Developing Countries
Authors: Pham Diem Thi Thuy , Nguyen Hoai Trong
Published: November 2024

This study analyses the effect of financial development on economic growth in 64 developing countries during the period 2003–2017 using a Bayesian model averaging approach. The results indicate that financial development has a significant U-shaped effect on economic growth, providing new insight concerning the relationship between financial development and economic growth. We also demonstrate that investment to gross domestic product ratio and foreign direct investment have significant positive effects on economic growth, whereas population growth has a significant negative impact on economic growth.
JEL classification: C11, N2, O1, O4.
IDENTIFICATION OF NEW CHEMICAL ENTITIES AS VHL INHIBITORS FOR DIABETIC WOUND HEALING
Authors:   Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Ooty-643001, Tamil Nadu, India, Mariappan Esakkimuthukumar , Thiruselvan Gokula Krishnan , Sam Jenkinson Sam Harrison , Appavoo Saravana Kumar Chellaperumal , Krishnamoorthi Suranther , Swaroop Akey Krishna , Selvaraj Jubie
Published: November 2024

Diabetes is a kind of endocrine disease that impacts around 6% of the world's population. Globally, 68% of amputations were performed in persons with diabetes. Hypoxia-inducible factor 1-alpha (HIF-1) is a crucial regulator of wound healing in diabetic patients, which includes epithelialization, angiogenesis, granulation, tissue development, and wound contraction. Even though diabetic wounds are hypoxic, HIF-1 levels are decreased during diabetic conditions. Diabetic wound healing necessitates the modulation of hypoxia-induced responses by VHL–HIF-1 protein-protein inhibition (PPI). Our proposed hypothesis is to increase HIF-1 levels by inhibiting VHL and HIF-1 interactions by small bioactive molecules, accelerating diabetic wound healing. Three features (Two hydrogen bond acceptors and One hydrogen bond donor) pharmacophore model was generated from the existing VHL inhibitors. Virtual screening was done based on the generated pharmacophore, and a library of 700 compounds was selected using ZINCPharmer. Based on the docking analysis the Top 15 HITs were selected & after performing ADMET studies, the Top 2 HITs (ZINC04214700 and ZINC12529886) were identified as potential VHL inhibitors. From this finding, we demonstrated that inhibiting the VHL and HIF-1 connection is a promising strategy for treating diabetic wounds.
CHORIOCARCINOME GESTATIONNEL DECOUVERT A J46 DUN ACCOUCHEMENT NORMAL
Authors:   Service de Gynecologie-Obstetrique CHR Hassan II-Agadir., Krite Saloua , El Farouqui Abdalah ,   Service de Gynecologie-Obstetrique CHR Hassan II-Agadir.
Published: November 2024

The choriocarcinoma is a rare and aggressive tumor that can grow quickly and spread easily to other parts of the body, sometimes occurring after spontaneous or elective abortion, tubal pregnancy or, more rarely, normal pregnancy. In our case, we reported abnormal uterine bleeding following vaginal delivery at day46. The post-partum period was unremarkable, and the diagnosis of gestational choriocarcinoma was evoked and retained in view of the clinical, biological and radiological picture, management was multidisciplinary and timely, and the prognosis was favorable.
ANAESTHESIA MANAGEMENT IN A CASE OF HYPERTHYROID WITH PROPTOSIS FOR ENDOSCOPIC DECOMPRESSION
Authors: Raj Ashish , Jadhav Mona
Published: November 2024

This article describes a case of a 65-year-old man with hyperthyroid and who underwent left orbit endoscopic decompression for left eye proptosis. The article also discusses the management of thyroid eye disease (TED) in general. Thyroid associated orbitopathy, also known as Graves orbitopathy, is the most common cause of proptosis ( bulging of the eye). It is an autoimmune disease that affects the muscles and fatty tissues around the eye. TED is most commonly associated with Graves disease, an autoimmune disease that causes an overactive thyroid gland. However, TED can also occur in people with normal thyroid function or an hyperactive thyroid gland. The article presents a case of a 65-year-old man with TED who underwent decompressive surgery to relieve pressure . The article also discusses the importance of maintaining euthyroid (normal thyroid function) in patients with TED.
REFLECTION ON KEY ELEMENTS AND CHALLENGES OF TRIBES OF KERALA IN HIGHER EDUCATION: ROLE OF POLITICS AND ECONOMY
Authors:   Assistant Professor School of Ethics, Governance Culture and Social System Chinmaya Vishwavidyapeeth Deemed to be University Piravom -682313., M.P. Bindu
Published: November 2024

One child, one teacher, one book, one pen can change the world. Education is education. We should learn everything and then choose which path to follow. Education is neither Eastern nor Western, it is human. Malala Yousafza (2014). Education is the root of development and is the must tool to ensure equality of opportunity following this philosophy, the central and state governments have been making various efforts to educate the masses. Even after intensive programmes and policies offered by the central and state government, the development hasnt reached the education sector among the tribal community. According to Unified District Information System for Education (UDISE) 2016-17 about 19.6% of students belong to Scheduled Castes at the primary level, but this fraction falls to 17.3% at the higher secondary level. These enrolment drop-offs are more severe for Scheduled Tribes students (10.6% to 6.8%), and differently-abled children (1.1% to 0.25%), with even greater declines for female students within each of these categories. The decline in enrolment in higher education is even steeper. (National Education Policy, NEP,2020). Weak academic performance and the increasing dropout rate are even today common among Scheduled Tribe communities. Politics, economy, community, and gender are correlated with ones life aspirations, overall learning skills, and adjustment to the educational institution.
Iron deficiency conditions in gynaecology: Effective management of perioperative anaemia
Authors: Vinogradova M. A. , Serebriyskaya D. S.
Published: November 2024

Iron deficiency anaemia is one of the most common diseases among women, and is most often caused by posthemorrhagic conditions. Gynaecological diseases requiring surgical treatment play a determinant role in the genesis of heavy iron loss in women. Anaemia can prevent from the timely surgery, and failure to eliminate local causes of blood loss can deteriorate the patients’ condition and quality of life. Anaemia is currently regarded as a serious risk factor for the outcomes of surgical treatment, which can and should be eliminated. At the same time, substitution transfusion that was previously often used to manage anaemia in less time is not only ineffective and has a temporary effect, but can itself cause such serious complications as haemolysis, infection, anaphylaxis. Therefore, it is recommended to apply an approach that combines diagnosis and treatment of anaemia, reduces blood loss and improves the general condition of patients. This approach can lead to about 40% reduction in the incidence of complications. The review summarizes the main features of iron deficiency anaemia in gynaecology and the most effective approaches to therapy. Early onset of modern oral ferrotherapy allows to assign treatment courses of required duration without side effects and prevents severe iron deficiency. Parenteral administration of iron carboxymaltose has significantly reduced the duration of treatment and improved its effectiveness in severe recurrent and perioperative anaemia. Timely management of anaemia allows not only to perform surgical intervention in time, when indicated, but also to reduce the likelihood of complications and improve the women’s quality of life.