bluuebunny/crossref_metadata_2025 huggingface dataset:
Esophageal perforation in premature newborns
Authors: Karavaeva Svetlana A. , Kotin Alexey N. , Volert Tatiana A. , Kornilova Anna B. , Gopienko Mikhail A. , Volkov Alexander N.
Published: October 2024

BACKGROUND: Esophageal perforation is a rare entity in newborns. This condition is most common in premature babies with very low and extremely low birth weight. The major cause of such pathology is considered to be iatrogenic trauma of either pharynx or esophagus, their soft tissues being delicate and tender enough to produce delamination and perforation of their wall. As a rule, this occurs as a complication of either a difficult tracheal intubation soon after birth or during some troubles with oro- or nasogastric tube insertion.
AIM: To analyze our experience of revealing and treatment of esophageal perforation in preterm babies, and to demonstrate conservative approach as a possible as well as reasonable option in such cases.
METHODS: A retrospective study of neonatal esophageal perforation cases was performed, including newborns without any congenital esophageal malformations or previous surgical procedures. During 2017–2022 9 newborns with esophageal perforation were treated at neonatal intensive care unit and neonatal departments of Childrens’ City Multidisciplinary Clinical Specialized Center of High Medical Technologies of Saint Petersburg. All of them were premature, 2 having very low, and 7 having extremely low birth weight. The incidence of that condition appeared to be 1:1320 live births.
RESULTS: 8 patients were treated conservatively. This included adjustment of artificial lung ventilation, pain control, antibiotics, cancellation of gastric enteral feeding and administration of total parenteral nutrition. Babies with hydrothorax, pneumothorax or ascites underwent thoraco- or laparocentesis. 2 patients died, both being born at 23th week of gestation. In both cases death occurred from polyorganic insufficiency. The mortality rate appeared to be 22%.
CONCLUSION: In most cases the esophageal perforation in premature babies can be treated conservatively, the efficacy of such treatment being largely dependent on early diagnosis of this complication. An important key-point in it is a radiologic control of gastric tube location.
Prospects for the use of perampanel in the treatment of epilepsy in patients with malignant gliomas of the brain
Authors: Wang Yi , Mufazalova Natalia A. , Mufazalova Lyaysan F. , Ilyasova Nailya V. , Muradova Raila R. , Kiyomov Ikhtiyor E. , Davurova Laylo Sh. , Samorodov Aleksandr V.
Published: October 2024

Epilepsy occurs in 35–95% of patients with low-grade malignant cerebral gliomas and in 29–71% of patients with high-grade gliomas. Seizures can be the first manifestation of a malignant cerebral glioma or may develop in the postoperative period and during chemoradiation therapy. This necessitates the use of antiepileptic drugs that can control seizures, ensure seizure prevention, and provide secondary seizure prophylaxis without reducing the effectiveness of anticancer therapy or the patient’s quality of life. The processes of epileptogenesis and oncogenesis are closely interrelated through common developmental mechanisms, with glutamate playing a key role. Increased glutamate secretion is accompanied by elevated expression and activation of its receptors, which raises seizure susceptibility. This is associated with increased levels of brain-derived neurotrophic factor, the number of synapses between peritumoral neurons and glioma cells, and the expression of various growth factors, all of which contribute to tumor progression. In this context, special attention is given to perampanel, a glutamate receptor antagonist and third-generation antiepileptic drug, in the treatment of epilepsy in patients with malignant cerebral gliomas. It has been shown that perampanel not only effectively controls seizures in patients with malignant cerebral gliomas but also suppresses tumor progression. Perampanel can dose-dependently enhance apoptosis and disrupt cell migration in malignant glioma cell lines. A synergistic effect of perampanel in combination with temozolamide has been identified. During chemoradiation therapy, perampanel exerts a protective effect on healthy peritumoral tissues. Adverse drug reactions associated with perampanel use are infrequent and mild. Further research is needed to investigate the anticonvulsant and antitumor efficacy of perampanel for the treatment of epilepsy in patients with malignant brain tumors.
Impact of social stress in early ontogenesis on food addiction and ghrelin levels in the hypothalamus of rats
Authors: Lebedev Andrey A. , Droblenkov Andrey V. , Pyurveev Sarng S. , Kosyakova Galina P. , Bezverkhiy Aleksandr A. , Lebedev Viktor A. , Netesa Maria A. , Shabanov Petr D.
Published: October 2024

BACKGROUND: Factors that can trigger episodes of binge (compulsive) eating include psychological and physical stress. Our studies have shown that maternal deprivation in early ontogenesis leads to an increase in elements of gambling addiction in the Iowa Gambling Task test. This raises the question of the role of maternal deprivation in the development of other types of non-chemical addictions, particularly food addiction.
AIM: To study the role of ghrelin in the manifestation of food addiction elements in rats subjected to maternal deprivation in early ontogenesis.
MATERIALS AND METHODS: Wistar rats were separated from their mothers for 180 minutes daily from day 2 to day 12 after birth. Male rats aged 90–100 days were used in the experiments. To induce compulsive overeating, the animals were given a high-carbohydrate diet (a mixture based on chocolate paste) for 1 hour every third day for 1.5 months. Fifteen minutes before feeding, the chocolate paste was placed within 5 cm of the rat’s reach with visual contact. After compulsive overeating was established, the number and area of ghrelin-producing neuroendocrine cells in the hypothalamus were analyzed using immunohistochemistry in intact rats and animals subjected to maternal deprivation stress.
RESULTS: It was shown that intermittent consumption of the chocolate mixture predicted overeating in rats, independent of weight gain or obesity, as a result of compulsive overeating. In studying the effect of maternal deprivation on chocolate consumption, it was found that the average daily consumption in the maternal deprivation group increased (p 0.001) compared to the control group. However, there was no significant difference in standard food consumption between the maternal deprivation and control groups. The number and area of ghrelin-producing neuroendocrine cells in the lateral portion of the medial arcuate nucleus of the hypothalamus were reduced in rats after maternal deprivation.
CONCLUSIONS: It was concluded that early psychogenic stress from maternal deprivation causes a dysregulation of the ghrelin system, contributing to elements of food addiction in rats.
La division sociale de la langue: la fiction d’une langue populaire
Authors: Ducard Dominique
Published: October 2024

Résumé: L’objectif de cet article est de montrer, à travers un parcours de textes d’historiens et de (socio)linguistes, comment le discours sur la langue française, dans sa formation et son fonctionnement, est traversé par l’idée d’une division sociale constitutive d’une “langue populaire”, identifiée à une classe sociale et dévaluée. Cette investigation interroge la notion de langue et son image dans la conscience linguistique des sujets et conduit à poser la question de l’institution sociale de la langue. La langue commune, pluralisée et diversifiée dans le discours historique et linguistique, se double d’une référence à une langue normée, instituée par l’école, dont les effets ont été soulignés dans les travaux originaux de Renée Balibar. Nous finissons ainsi par une évocation des thèses de cet auteur, avec une mise en perspective de la langue normée, dans son rapport aux styles littéraires, avec la transposition des variations sociales dans la langue de la fiction.  Mots clés: langue populaire; classe sociale; conscience linguistique; norme; institution.Abstract: The objective of this paper, exploring historical and (socio) linguistic texts, is to highlight how the discourse on the French language, its formation and function, is spanned by the idea of a social division constituting of a “popular language”, identified with a social class and devalued. This investigation questions the notion of language and its image in the linguistic conscience and it raises the problem of the social institution of language. The common language, pluralized and diversified in the historical and linguistic discourse, is doubled up as a standard language, established by school, whose effects have been pointed out in the original works of Renée Balibar. So we finally mention the thesis of this author and put the standard language in perspective, as it relates to literary styles, with the transposition of social variations in a fiction language.Keywords: Popular Language; Social Class; Linguistic Conscience; Norm; Institution.
A Onomástica em diferentes perspectivas: resultados de pesquisas / Onomastics in different perspectives: research results
Authors: Seabra Maria Cândida Trindade Costa de , Isquerdo Aparecida Negri
Published: October 2024

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Seller’s Liability under Article 42 of the CISG
Authors:   Korean Academy Of International Commerce, Inc., Lee Byung-Mun , An Ye-Eun
Published: October 2024

Purpose: This study explores the liability of sellers of goods that infringe Article 42 of the United Nations convention on Contracts for the International Sale of Goods (CISG) based on the official opinion of the CISG Advisory Council.
Research design, data, and methodology: The requirements for seller liability under Article 42(1) of the CISG includes the seller's awareness and geographic limitations. This study also examines the requirements for seller immunity under Article 42(2), including the buyer's expectation of awareness and investigation.
Results: M ost o f t he e xisting o pinions a nd t he o fficial o pinions o f t he C ISG A dvisory Council seem to be consistent with the responsibility of the seller who delivers goods infringing on intellectual property rights. However, regarding the timing for determining the suitability of rights to the goods, there are areas where opinions are different from those of scholars who view them as a transfer of risk.
Conclusions: The CISG Advisory Council's official opinion appears to be a reasonable interpretation of Article 42 taking into account its purpose, which is to protect the interest of the purchaser in the free use of goods that are not subject to third-party rights or claims, the Secretariat's commentary on the Convention's legislative history, and the existing views of scholars. Therefore, practitioners should prepare for related situations by referring to the official opinion of the CISG Advisory Council on Article 42 of the CISG.
Research on Packaging Design Elements for Expanding Market Share of Fruit Juice Beverages in China
Authors:   Korean Academy Of International Commerce, Inc., Hu Liling , Chen Maowei
Published: October 2024

Purpose: By examining Chinese consumers’ preferences and needs in fruit juice beverage packaging design, this study provides scientifically grounded strategies and solutions for researching and developing packaging designs in the juice beverage industry.
Research design, data, and methodology: This study systematically analyzes the packaging design of fruit juice beverages and introduces a demand evaluation methodology for fruit juice beverage packaging by integrating the Kano model and the Analytic Hierarchy Process (AHP).
Results: Based on the calculation results, ‘Nontoxic’ and ‘Clear ingredient information’ were important in Must-Be Quality Element. ‘Portable’ and ‘Lightweight performance’ were the top 2 in One-Dimensional Quality Element. In the Attractive Quality Element, ‘Unique pattern’ was identified as the most important factor.
Conclusions: The analysis results of this study suggest the importance of fruit juice beverage packaging design elements preferred by Chinese consumers and are expected to be used as reference material by Korean companies in the future when preparing plans to enter and expand into the Chinese beverage market.
Utilization of Blockchain Electronic Bills of Lading in the 4IR Era: An Empirical Study
Authors:   Korean Academy Of International Commerce, Inc., Kim Chang-Bong , Lee Hee-Bin
Published: October 2024

Purpose: This paper evaluates the factors influencing the adoption and use of blockchain’s electronic bill of lading (e-B/L) in the trade and logistics industry, assessing its practical acceptability and suggesting future research directions.
Research design, data, and methodology: This paper developed a research model based on prior studies and technology acceptance models, and used survey data from Korean trade and logistics firms to identify factors influencing e-B/L adoption.
Results: Availability and suitability of a blockchain e-B/L influences its perceived ease of use positively, while security and suitability influences perceived usefulness positively. Both perceived ease of use and perceived usefulness had a positive impact on the intention to use.
Conclusions: This paper provides practitioners and researchers in the field of trade logistics with in-depth insights into the key factors influencing the adoption and utilization of a blockchain e-B/L, and provides a useful basis for future research and practical decisions.
Transformational Leadership and Employee Satisfaction on Employee Loyalty: The Mediating Role of Employee Engagement
Authors: Wardana I Made Aditya , Salain Putu Pradiva Putra , Dwinata JS I Putu Wahyu
Published: October 2024

Research aims: This study investigates employee loyalty among hospitality businesses despite improvements after the pandemic. It scrutinizes the influence of transformational leadership on employee satisfaction, engagement, and loyalty and assesses the mediating role of employee engagement.Design/Methodology/Approach: A quantitative design was implemented, and data were collected employing a questionnaire circulated to 261 employees. Then, the accumulated data was investigated using the Smart PLS 3.2.9 application.Research findings: The study highlights that transformational leadership affects employee loyalty while employee satisfaction does not. Employee engagement mediates the linkage between transformational leadership and employee satisfaction and loyalty. Employees need satisfaction to cover their turnover chances and remain loyal.Theoretical Contribution/Originality: The study expands the existing literature concerning the role of transformational leadership and job satisfaction in reinforcing employee loyalty. This type of study is infrequently due to its significant focus on performance.Practitioners/Policy Implications: Hotel business managers pay more attention to employee engagement in every activity. Accordingly, employee loyalty can be maintained, impacting hotel performance.Research Limitations/Implications: This study was performed on the four-star hotels. Consequently, these results cannot be fully implemented in different businesses. Various further elaborations are required to make it applicable to different sectors.
Malpractice litigation in multidisciplinary cancer care: Navigating medico-legal challenges and shared decision making in India
Authors: Mahani Anmol , Zadu Rudranath
Published: October 2024

Healthcare professionals participating in multidisciplinary team (MDT) cancer meetings may not have a comprehensive understanding of their medicolegal responsibilities in current times. This article aims to delineate the principal medicolegal issues pertinent to multidisciplinary cancer care and offer recommendations for future implementation. Key concerns highlighted in this literature encompass patient consent and privacy during MDT meetings, professional liability, the formal expression of dissenting views and the duty of care. The analysis of existing literature prioritizes several recommendations for addressing these issues. Given the limited precedent available for formulating recommendations, this article identifies foundational evidence that can inform the practicing clinicians of these concerns in future MDT practices.

Navigating decision-making processes in cancer care poses significant challenges for patients. This article seeks to elucidate the significance of shared decision making (SDM) within the Indian clinical context while pin pointing disparities compared to Western practices. Through a systematic search conducted in Medline and Google Scholar from 2000 to 2019, approximately 400 articles were screened, resulting in the selection of 43 relevant articles (5 from India and 38 from Western sources). The literature underscores a scarcity of information on shared decision making in India as compared to Western contexts, potentially leading to adverse physical, psychological and financial consequences reported by patients. According to one study, While Western data demonstrate extensive involvement of both patients and physicians in consensus-building for treatment decisions, such engagement in India is predominantly observed in tertiary care settings, academic institutions or cases with high therapy costs. Cultural beliefs and biases further influence patient engagement, while communication breakdowns correlate strongly with medicolegal malpractice litigations. Future research endeavours are warranted to explore strategies for integrating shared decision making into routine oncology practice in India. Physicians must actively involve patients or their immediate family members in decision-making processes to ensure a patient-centric approach, thereby mitigating the risks of un-informed decision-making or mistrust in the treating physician's expertise. Efforts such as physician and patient education, tool development, policy formulation, widespread implementation and periodic assessments hold promise for advancing the practice of shared decision making.
Correlation of CT measurements of total body gas volume and hounsfield units with post-mortem interval
Authors: Taher Mohamed Mohamed Ben , Skerry Timothy M , Cohen Marta C , Russell Jean , Offiah Amaka C
Published: October 2024

Accurate estimation of the post-mortem interval (PMI) may be a matter of crucial importance in forensic investigations.

A preliminary investigation to assess whether longitudinal changes in organ Hounsfield units (HU) and total body gas volume (TBGV), as measured from serial PMCT scans, correlate with postmortem interval (PMI).

: Eight euthanised lambs each had five whole body CT scans performed over seven days and measurements were taken from the brain, heart, lungs, liver, kidneys and spleen. HU tissue density was measured directly from the PMCT images, while TBGV was calculated using ImageJ software. A random effect model was fitted with the subject fitted as a random intercept. Ethical and Animal Welfare approval was obtained.

: The average increase in TBGV was 422 ml/Kg with a change of 77 ml/Kg per day. For each additional post-mortem day, the HU of the brain, heart, lung, liver and spleen decreased by per day since death, while HU for the kidneys increased by day since death.

Expect for the kidney where it increased, there was clear and progressive decrease in tissue densities and for all organs there was an increase in TBGV over time. However, the overlap in values between cases indicates that more work is required before either HU or TBGV can be developed as non-invasive methods to reliably determine time of death in humans.
Soil: forensic interpretation some cases study
Authors: Sharma Mukesh , Bansal Kanika , Daga S. S
Published: October 2024

While investigating a crime scene related to murder, hit-and-run accidents, road accident analysis, vehicles collisions, rapes and burglaries, forensic soil examination is used for linking the suspect or an object to the crime scene.

Comparison of soil provide information about location and place where from picked up by an automobile tire (location) with the soil sample taken from the crime site may help to prove that the suspect automobile may have been used in crime (place of happening). Similarly, soil or mud found adhering to clothing or shoes of a person may provide the clue that can link a suspect to a particular crime site.

In the present study we reported the importance of soil and their interpretation as forensic evinces. The study has been reported with the help of cases study to provide exemplary explanation.
Knockout of TMEM206 in mice associated with a loss of corneal transparency
Authors:   Department of Ophthalmology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201801, China, Yang Zi-Jian , Zhou Yu-Feng ,   Department of Ophthalmology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201801, China, Sun Shun-Chang ,   Department of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201801, China
Published: October 2024

AIM: To investigate the role of transmembrane protein 206 (TMEM206) in corneal edema in mice by knockout the TMEM206 gene using CRISPR/Cas9 editing technology.
METHODS: TMEM206-knockout mice were generated using the CRISPR-Cas9 system. Variations in ophthalmic pathology were observed using slit lamp microscope and optical coherence tomography (OCT), intraocular pressure (IOP) was measured using a TonoLab Rebound Tonometer, and the ultrastructure of the corneal was observed using a transmission electron microscope.
RESULTS: Corneal opacity was observed in 4/18 homozygous TMEM206-/- mice whereas a similar change was not observed in heterozygous TMEM206+/- mice and wild-type littermates. OCT examination showed that the mean central cornea thickness was 125±5.4 µm in 4 homozygous TMEM206-/- mice developed corneal edema and 115±1.2 µm in wild-type mice (t=3.468, P<0.05) at 43wk. The mean IOP was 12.08±0.07 mm Hg in four right eyes with corneal edema and 12.03±0.03 mm Hg in three normal left eyes (P>0.05). Transmission electron microscopy revealed a disruption in the organization of the collagen fibrils in the central part of the cornea in homozygous TMEM206-/- mice.
CONCLUSION: TMEM206 is associated with corneal edema which caused organizational disruption of collagen fibrils in corneas of mice.
NMI, POLR3G and APIP are the key molecules connecting glaucoma with high intraocular pressure: a clue for early diagnostic biomarker candidates
Authors:   Department of Ophthalmology, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia, Almarzouki Nawaf
Published: October 2024

AIM: To understand the molecular connectivity between the intraocular pressure (IOP) and glaucoma which will provide possible clues for biomarker candidates.
METHODS: The current study uncovers the important genes connecting IOP with the core functional modules of glaucoma. An integrated analysis was performed using glaucoma and IOP microarray datasets to screen for differentially expressed genes (DEGs) in both conditions. To the selected DEGs, the protein interaction network was constructed and dissected to determine the core functional clusters of glaucoma. For the clusters, the connectivity of IOP DEGs was determined. Further, enrichment analyses were performed to assess the functional annotation and potential pathways of the crucial clusters.
RESULTS: The gene expression analysis of glaucoma and IOP with normal control showed that 408 DEGs (277 glaucoma and 131 IOP genes) were discovered from two GEO datasets. The 290 DEGs of glaucoma were extended to form a network containing 1495 proteins with 9462 edges. Using ClusterONE, the network was dissected to have 12 clusters. Among them, three clusters were linked with three IOP DEGs [N-Myc and STAT Interactor (NMI), POLR3G (RNA Polymerase III Subunit G), and APAF1-interacting protein (APIP)]. In the clusters, ontology analysis revealed that RNA processing and transport, p53 class mediators resulting in cell cycle arrest, cellular response to cytokine stimulus, regulation of phosphorylation, regulation of type I interferon production, DNA deamination, and cellular response to hypoxia were significantly enriched to be implicated in the development of glaucoma. Finally, NMI, POLR3G, and APIP may have roles that were noticed altered in glaucoma and IOP conditions.
CONCLUSION: Our findings could help to discover new potential biomarkers, elucidate the underlying pathophysiology, and identify new therapeutic targets for glaucoma.
Correlation between blepharospasm and psychological diseases: the anxiety, depression and sleep disorder study
Authors:   Eye Center of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China, Zhang Hui-Na , Xie Jia-Jun ,   Eye Center of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China, Ye Juan ,   Eye Center of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China
Published: October 2024

AIM: To investigate the relationship between benign essential blepharospasm (BEB) symptoms and depression/anxiety/sleep disorder in a prospective manner and to determine whether treatment the BEB with botulinum toxin type A (BoNT/A) can impact psychological symptoms.
METHODS: This prospective interventional case series recruited 61 adults with evidence of BEB. Patients were administered the Jankovic Rating Scale (JRS), the Blepharospasm Disability Index (BSDI), Personal Health Questionnaire Depression Scale (PHQ-8), Generalized Anxiety Disorder 7-item scale (GAD-7) and the Athens insomnia scale (AIS) to evaluate the severity of BEB symptoms, depression, anxiety and sleep disorder before and 1wk, 1, 3mo after the BoNTA treatment. Statistical analysis was performed to assess the relationships between changes in the survey scores.
RESULTS: The mean score for JRS, BSDI, PHQ-8, and GAD-7 improved significantly (P<0.0001), respectively, compared to the initial visit at follow-up. At baseline, worse BSDI scores were correlated with worse GAD-7 and PHQ-8, but not with worse AIS. At 1mo follow-up visit, there was no correlation between change in BSDI and PHQ-8/AIS, the change in GAD-7 showed a mild association with change in BSDI. The change in BSDI was correlated with the change in both PHQ-8 and GAD-7 in the subgroup of patients without a prior diagnosis of depression or anxiety. Patient satisfaction with BoNT/A treatment reached the highest at 1mo of follow-up (83.6%, 51/61).
CONCLUSION: BEB may lead to psychological diseases. BoNT/A can significantly improve motor and non-motor symptoms of BEB, which emphasize the effectiveness of BoNT/A and therefore pave the way for its use in the field of psychiatry. However, further research is needed to confirm these findings and understand the underlying mechanisms.
Intraocular lens exchange or explantation post cataract surgery
Authors:   Department of Cataract, LV Prasad Eye Institute, Kallam Anji Reddy Campus, Hyderabad 500034, Telangana, India; Shantilal Shanghvi Cornea Institute, LV Prasad Eye Institute, Kallam Anji Reddy Campus, Hyderabad 500034, Telangana, India, Dvivedi Arundhati , Manga Sukesh ,   Department of Cataract, LV Prasad Eye Institute, Kallam Anji Reddy Campus, Hyderabad 500034, Telangana, India
Published: October 2024

AIM: To report incidence, indications, and visual outcomes of intraocular lens (IOL) exchange/explantation surgery.
METHODS: Retrospective analysis of 60 eyes requiring IOL exchange/explantation surgery between 1st January 2017 and 31st December 2022. The overall outcomes as well as comparison between the trainee versus experienced surgeons were analyzed.
RESULTS: Out of 39 778 cataract surgeries (with no preexisting ocular co-morbidities) during a six-year period (2017–2022), 60 (0.15%) needed IOL exchange/explantation. Surgeons-under-training performed 36/60 cases (60%) while 24/60 (40%) were by experienced surgeons. The commonest indication was subluxated IOL in 26 (43.3%), followed by dislocated IOL in 20 (33.3%), postoperative refractive surprise in 7 (11.6%), IOL induced uveitis in five and broken haptic in two eyes. Twenty-four (40%) eyes had intraoperative complications during primary surgery. Posterior chamber IOL (PCIOL) was the commonest secondary IOL in 21 (35%) eyes, scleral fixated in 20 (31.6%), anterior chamber IOL (ACIOL) in 13 (21.6%), iris fixated IOL in three (5%) and three eyes (5%) were left aphakic. The mean time between primary and secondary surgery was 168d (168±338.8). Best corrected visual acuity (BCVA) of >20/60 was obtained in 43 eyes (71.66%), 20/80–20/200 in 14 (23.33%), 20/250 in two and hand movements in one. No statistically significant difference in visual outcome was noted at post-op one month between trainees versus experienced surgeons (UCVA 0.45±0.29 vs 0.53±0.32, P=0.20, BCVA 0.34±0.25 vs 0.37±0.26, P=0.69).
CONCLUSION: IOL subluxation as the commonest indication and posterior capsular rupture is the commonest intraoperative risk factor. This complication can be effectively addressed with selection of the appropriate secondary IOL achieving good visual outcomes in over 70% of patients.
Short-term effectiveness of intelligent navigated laser photocoagulation versus subthreshold micropulse laser in patients with chronic central serous chorioretinopathy
Authors:   Nanjing Medical University Affiliated Eye Hospital, Nanjing 290091, Jiangsu Province, China, Zhou Fen , Zhou Chen-Chen ,   Nanjing Medical University Affiliated Eye Hospital, Nanjing 290091, Jiangsu Province, China, Liu Sha ,   Nanjing Medical University Affiliated Eye Hospital, Nanjing 290091, Jiangsu Province, China, Yao Jin ,   Nanjing Medical University Affiliated Eye Hospital, Nanjing 290091, Jiangsu Province, China, Jiang Qin ,   Nanjing Medical University Affiliated Eye Hospital, Nanjing 290091, Jiangsu Province, China
Published: October 2024

AIM: To compare the short-term effectiveness of intelligent navigated laser photocoagulation and 577-nm subthreshold micropulse laser (SML) treatment in patients with chronic central serous chorioretinopathy (cCSC).
METHODS: This observational retrospective cohort study included 60 consecutive patients who underwent intelligent navigated laser photocoagulation (n=30) or 577-nm SML treatment (n=30) for cCSC between Jan. 2021 and Oct. 2022. During 3mo follow-up, all patients underwent assessments of best correct visual acuity (BCVA) and optical coherence tomography (OCT).
RESULTS: The operation of laser treatment was successful in all cases. At 1mo, BCVA improved significantly more in the intelligent navigated laser photocoagulation group compared to the SML group (P<0.05). The change was not significantly different at 3mo (P>0.05). Central macular thickness (CMT) in the intelligent navigated laser photocoagulation group was lower than in the SML group at 1mo (P<0.05). The subfoveal choroidal thickness (SFCT) in two groups were all significantly improved at 3mo (all P<0.05). The change between two groups was not significantly different at 1mo or at 3mo (P>0.05).
CONCLUSION: Intelligent navigated laser photocoagulation is superior to SML for treating cCSC, leading to better improvements in vision and CMT for short term.
Short-term fluctuation of intraocular pressure and influencing factors following intravitreal injection in patients with retinal vascular diseases
Authors:   Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Institute of Ophthalmology, Beijing Key Laboratory of Institute of Ophthalmology and Visual Sciences, Beijing 100730, China, Miao Jing-Peng , Gu Xin-Ming ,   Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Institute of Ophthalmology, Beijing Key Laboratory of Institute of Ophthalmology and Visual Sciences, Beijing 100730, China, Zhang Xin-Yuan ,   Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Institute of Ophthalmology, Beijing Key Laboratory of Institute of Ophthalmology and Visual Sciences, Beijing 100730, China
Published: October 2024

AIM: To investigate the patterns of short-term intraocular pressure (IOP) fluctuations and identify the contributing factors following intravitreal injection in patients with retinal vascular diseases.
METHODS: Totally 81 patients were enrolled in this case control study. Eyes were categorized into 7 groups, including age-related macular degeneration (AMD), polypoidal choroidal vasculopathy (PCV), idiopathic choroidal neovascularization (CNV), proliferative diabetic retinopathy (PDR), diabetic macular edema (DME), macular edema secondary to branch (BVOME) and central (CVOME) retinal vein occlusion. IOP was measured in all patients using rebound tonometer at 7 preset time points perioperatively. Additionally, based on the administered medication, the eyes were classified into three treatment groups, including dexamethasone intravitreal implant (IVO), intravitreal conbercept (IVC), and intravitreal ranibizumab (IVR). To compare IOP values at various time points across groups, we employed one-way ANOVA, independent sample t-test or χ2 test and multivariate logistic regression analysis.
RESULTS: Peak IOP values across all groups were observed at 40s, and 5min after intravitreal injection. Statistical differences in IOP were detected at the 5min among the 7 indication groups (F=2.50, P=0.029). When examing the impact of medications, the IVO group exhibited lower average IOP values at both 40s and 5min compared to the IVC and IVR groups (P<0.001; P=0.007). The IOP values at 40s and 5min were significantly higher in BVOME and CVOME group compared to non-retinal vein occlusion-secondary macular edema (RVOME) group (P<0.001). Multivariate logistic regression analysis further confirmed that IOP measurement at 40s was significantly higher in CVOME group than in non-RVOME group (OR=1.64, 95%CI: 1.09-2.47; P=0.018).
CONCLUSION: Needle size plays a crucial role in the transient changes of IOP following intravitreal injection. Before administering intravitreal injection to patients with central retinal vein occlusion, it is essential to exclude any underlysing causes of increased IOP.
Avaliação da eficácia do método oficial para detecção de neutralizantes químicos (hidróxido de sódio e bicarbonato de sódio) em amostras de leite
Authors: Silva Maria Stéfane Da , Souza Karolyne Amorim , Goulart Simone Machado , Castro Leonardo Magalhães de , Santos João Paulo Victorino
Published: October 2024

O controle de qualidade e a segurança na cadeia produtiva do leite são prioridades para técnicos e órgãos reguladores. Medidas como higienização das instalações, higiene pessoal, qualidade da matéria-prima e uso de maquinário adequado são rigorosamente regulamentadas e inspecionadas para minimizar o risco de contaminação do produto. Entretanto, ainda ocorrem casos de contaminação por agentes químicos, como neutralizantes de acidez, utilizados para mascarar acidez titulável causada por microrganismos devido a más condições de higiene e refrigeração inadequada. Nesse contexto, o presente estudo teve como objetivo avaliar a eficácia do método oficial na detecção de neutralizantes químicos em diferentes concentrações. Para tanto, amostras foram preparadas com níveis de acidez de 0,14%, 0,18%, 0,20% e 0,22% e testadas com hidróxido de sódio e bicarbonato de sódio em concentrações próximas ao limite de detecção. Os resultados indicaram que o método oficial não é eficaz na detecção desses neutralizadores em níveis elevados de acidez, comprometendo a avaliação da qualidade do leite. O estudo sugere a necessidade de combinar diferentes metodologias analíticas, pois a falha do método oficial, associada à acidez do leite, pode permitir a comercialização de um produto com qualidade comprometida, representando um potencial risco à saúde dos consumidores.
Research on bridge safety early warning method based on strain energy theory and health monitoring data
Authors: Li Yinghua , Zeng Xiaoqing , Tang Yanxing
Published: October 2024

Bridges are technology-intensive and heavily invested permanent infrastructure. After completion and opening to traffic, bridge structures are easy to be affected by factors such as traffic load and atmospheric environment. Therefore, it is necessary to do safety warning and evaluation of bridges, especially the abnormal behavior in the early stages of bridge operation. In this research paper, a large-span continuous rigid frame bridge installed with the health monitoring system (HMS), of which a large amount of health monitoring data are collected by the HMS, is used as an example, and then a bridge safety early warning method is proposed when the bridge is during early operating period. First of all, the research finding that the internal stress of the prototype bridge obeys normal distribution through statistical analysis is used; next, we deduce that the strain energy inside the prototype bridge is subject to the Non-central Chi-square distribution combined with the strain energy and statistical theories; in the end, the key probability density distribution function of strain energy and its parameters are derived by using the key stress distribution function of the high performance concrete C50 strength grade used in the prototype bridge. The method recommended in this paper is conducive to the formulation of bridge preventive maintenance strategies.
Methodological approaches to the creation and functioning of serial robotic production of small satellites
Authors: Tkachenko I. S.
Published: October 2024

The article considers a system approach to the creation of robotic production of small nano satellites to ensure their serial production. The analysis of key trends in the creation and development of modern satellite production was carried out; the factors characterizing serial robotic production are identified and systematized. An intelligent production cell is described as the main element of serial robotic matrix-type production. The main types of design solutions aimed at adapting the design of a small satellite for robotic assembly are presented. The description of the project to create a prototype for serial production of small satellites in the format of a cyberphysical factory, implemented at the advanced aerospace engineering school of Samara University, is given.
Selection of design parameters of a spacecraft electric propulsion engine ensuring the geostationary orbit raising mission
Authors: Kolesov A. V. , Salmin V. V.
Published: October 2024

The problem of selecting suboptimal parameters of an electric propulsion system as part of a spacecraft, ensuring a geostationary orbit raising mission using a Soyuz-5 launch vehicle at the initial launch stage, is investigated. An expression is obtained for the main optimality criterion – the payload relative mass. An algorithm is obtained for solving the problem of parametric optimization of an electric propulsion system as part of a hybrid transportation system. The task of selecting the optimal electric propulsion engine for launching a spacecraft with an electric propulsion system to a geostationary orbit using the launch vehicle under consideration is solved. A design ballistic calculation and a comparative analysis of the obtained data are performed.
Social and emotional learning understood through the Oho and Ata resources
Authors: Lunjevich Cat , Roberts Josie
Published: October 2024

Cat Lunjevich responds to Set’s questioning about how her understanding of social emotional learning deepened along the journey of making the Oho and Ata cards, which are now readily available to New Zealand teachers.
Ka ara ake te akoranga i te whenua: Perspectives from the classroom and the field
Authors: Po Ching Jacinta , Harcourt Michael , Hirini Haimana
Published: October 2024

Teachers can respond to the climate crisis through deliberate choices about what and how to teach. We suggest that, for history teachers, this requires stepping outside traditional topics that often focus on political change. Instead, they need to select contexts for learning that illustrate how global forces of colonisation impact the ecology of local places and how iwi and hapū resist these changes. While this learning can begin in the classroom, it is not enough on its own. Wherever possible, teachers and students need to head into the field, alongside mana whenua. Furthermore, when this learning is consolidated by place-based projects that centre an Indigenous kaupapa, students become more active agents of change with a deep connection to the whenua. We share some of our experiences through excerpts from a reflective conversation between the three of us, two secondary school teachers and their student.
Delving into division
Authors: Hopkins Tracey , Mills Judith
Published: October 2024

When teaching the multiplicative domain in New Zealand primary schools, teachers tend to spend a greater proportion of time on the meaning and processes of multiplication, to the detriment of a specific focus on understanding the concept of division. When division is taught, it tends to be by reversing the context and turning the division scenarios into multiplication problems. While this article stems from wider research based on teaching division in Years 5 and 6, it is relevant to all primary school teachers as they teach the mathematical process of division to the students in their classroom.
La cultura en los Tratados de Libre Comercio de Colombia
Authors: Wodnicky Miriam Dermer
Published: October 2024

El objetivo del presente capítulo es precisar la perspectiva del gobierno colombiano en el proceso de liberalización comercial con relación al espacio de la cultura. En ese sentido la pregunta que se va a responder es: ¿cuál es el espacio de la cultura en los principales acuerdos comerciales de Colombia?
Latinoamérica: “el cuarto de san Alejo” en la geopolítica de Occidente. Comentario sobre la geopolítica latinoamericana
Authors: Torres-Torres Néstor Hugo
Published: October 2024

El presente ensayo tiene el propósito de hacer un comentario personal sobre la geopolítica latinoamericana a partir del curso de cualificación docente Geopolítica Moderna y Contemporánea, impartido por la Universidad La Gran Colombia. A riesgo de caer en una generalización que puede resultar impertinente, se toma a Latinoamérica como un objeto de estudio unitario, desde el argumento de que la mayor parte de su territorio fue colonizado por España, lo cual supone un punto común que puede determinar algunas tendencias que se repiten de forma muy similar en los Estados de América del Sur. La metodología usada corresponde con el enfoque cualitativo, desde la revisión de literatura y el análisis hermenéutico. El trabajo presenta como conclusión general que la geopolítica latinoamericana siempre ha dependido de algún poder estatal foráneo, el español o el estadounidense, razón por la cual se puede explicar la condición de subdesarrollo y la falta de apropiación de sistemas políticos propios y de procesos económicos más acordes con el mundo industrializado.
No entre el que no sepa geometría
Authors: Fonseca Martínez Miguel
Published: October 2024

La lógica sería la ciencia que permitiría tal corrección del pensamiento respecto de las entidades matemáticas. La primera metodología lógica planteada por Platón hace referencia al espacio, por supuesto, en coherencia con su educación geométrica. El método que preludia directamente el ejercicio de la lógica formal de Aristóteles es el método denominado diairesis expuesto con detenimiento en el Sofista. La lógica constituye entonces el primer esquema normativo en relación con el ser de las cosas. La norma, nomos , es una manifestación del orden del cosmos que se corresponde en todos los niveles del ser. Para Platón, el entendimiento y sus reglas precisamente se moverían de tal suerte, y según la disposición de los números. La lógica debe moverse como debe moverse el músico según las leyes de la armonía, si bien cada canción es diferente y particular cuando se llena de algún contenido.
El Teatro La Candelaria: hacia la construcción de los caminos del teatro y la identidad nacional
Authors: Wodnicky Miriam Dermer
Published: October 2024

El Teatro en Colombia ha sufrido de una serie de dificultades para su consolidación y en consecuencia se constituye en sujeto político mediante su constitución en sujeto cultural- teatral2, que mostró una insatisfacción respecto al poco desarrollo que este tema tiene en el Estado Colombiano de manera histórica por su tardía autonomía que se da a partir del año de 1968 con la creación de Colcultura, autonomía estatal que en su desarrollo ha sido rígida en la inclusión de las críticas y las especificidades de las prácticas teatrales que son una síntesis de necesidades, luchas y aportes relegados en relación con trayectorias culturales y con reflexiones sobre la identidad nacional colombiana.
Verdad y perdón: más allá de las instituciones
Authors: Carvajalino Slaghekke Alberto
Published: October 2024

El presente artículo aborda las razones de la ausencia del perdón en la historia del conflicto en Colombia como una posibilidad ignorada para acceder a la paz. Para tal fin explora los orígenes del perdón como concepto y establece diferencias con respecto a la utilización del concepto de verdad como una expresión tácita del perdón. Explica por qué la verdad resulta insuficiente para abordar la terminación de un conflicto y plantea la necesidad de acudir a la acción del perdón para llenar un vacío capaz de trascender el dolor de nuestra historia de conflictos y explorar una vía para la reconstrucción de un tejido social profundamente herido. El artículo también expone las razones que caracterizan la debilidad de los acuerdos políticos en nombre de un gobierno o partido político. Por ello, explora las experiencias en otros contextos culturales a través de investigaciones anteriores para comprender como los condicionamientos culturales facilitan o complican la utilización del perdón en la búsqueda de asentar la paz. Las ideas desarrolladas en el artículo tienen su origen en la investigación doctoral que indaga sobre las formas de la violencia en Colombia y la ausencia del perdón como mecanismo para acceder a la paz.
Leer la "Antología de mujeres poetas afrocolombianas". El territorio
Authors: Guardia Hernández Andrea Milena , Montejo Vélez Natalia , González Sánchez William Fernando
Published: October 2024

El proyecto de investigación “Leer desde las asimetrías: Poesía afrofemenina colombiana” (JCG2022_FCE_01) tiene como objetivo proponer una ruta de análisis literario con enfoque interseccional de un corpus de autoras colombianas racializadas que pueda ser utilizada en el ámbito de la educación básica en el área de Lenguaje. En consecuencia, se construye un recorrido por algunos poemas de la “Antología de mujeres poetas afrocolombianas”, publicada por el Ministerio de Cultura en 2010, a partir de la pregunta por el territorio, con el interés de ofrecer elementos de análisis que puedan ser implementados en las aulas y que permitan acercarse a los textos desde la reflexión sobre las relaciones entre los sujetos y los espacios, tanto físicos (como el barrio o la ciudad) como simbólicos (como el cuerpo o la idea de nación).
Talleres trabajo de grado
Authors: Bolívar Castañeda Cindy Cristina
Published: October 2024

Este documento es una guía para estudiantes que emprenden el camino hacía la investigación, para establecer la relación entre investigación, innovación y desarrollo social. Sus talleres son los siguientes: 1: Estado de la cuestión. 2: Población y contexto de la investigación. 4: identificación de problemas, el árbol de problemas - árbol de objetivos - estrategia óptima. 5: Descripción del problema y pregunta problema. 6: Formulación de hipótesis, objetivos y justificación. 7: Marco de referencia. 8: Diseño metodológico.