bluuebunny/crossref_metadata_2025 huggingface dataset:
Remote, proactive, telephone based management of toxicity in outpatients during adjuvant or neoadjuvant chemotherapy for early stage breast cancer: pragmatic, cluster randomised trial
Authors: Krzyzanowska Monika K , Julian Jim A , Gu Chu-Shu , Powis Melanie , Li Qing , Enright Katherine , Howell Doris , Earle Craig C , Gandhi Sonal , Rask Sara , Brezden-Masley Christine , Dent Susan , Hajra Leena , Freeman Orit , Spadafora Silvana , Hamm Caroline , Califaretti Nadia , Trudeau Maureen , Levine Mark N , Amir Eitan , Bordeleau Louise , Chiarotto James A , Elser Christine , Husain Juhi , Laferriere Nicole , Rahim Yasmin , Robinson Andrew G , Vandenberg Ted , Grunfeld Eva
Published: December 2021

Objective

To evaluate the effectiveness of remote proactive management of toxicities during chemotherapy for early stage breast cancer.

Design

Pragmatic, cluster randomised trial.

Setting

20 cancer centres in Ontario, Canada, allocated by covariate constrained randomisation to remote management of toxicities or routine care.

Participants

All patients starting adjuvant or neoadjuvant chemotherapy for early stage breast cancer at each centre. 25 patients from each centre completed patient reported outcome questionnaires.

Interventions

Proactive, standardised, nurse led telephone management of common toxicities at two time points after each chemotherapy cycle.

Main outcome measures

The primary outcome, cluster level mean number of visits to the emergency department or admissions to hospital per patient during the whole course of chemotherapy treatment, was evaluated with routinely available administrative healthcare data. Secondary patient reported outcomes included toxicity, self-efficacy, and quality of life.

Results

Baseline characteristics of participants were similar in the intervention (n=944) and control arms (n=1214); 22% were older than 65 years. Penetration (that is, the percentage of patients who received the intervention at each centre) was 50-86%. Mean number of visits to the emergency department or admissions to hospital per patient was 0.91 (standard deviation 0.28) in the intervention arm and 0.94 (0.40) in the control arm (P=0.94); 47% (1014 of 2158 patients) had at least one visit to the emergency department or a hospital admission during chemotherapy. Among 580 participants who completed the patient reported outcome questionnaires, at least one grade 3 toxicity was reported by 48% (134 of 278 patients) in the intervention arm and by 58% (163 of 283) in the control arm. No differences in self-efficacy, anxiety, or depression were found. Compared with baseline, the functional assessment of cancer therapy trial outcome index decreased by 6.1 and 9.0 points in the intervention and control participants, respectively.

Conclusions

Proactive, telephone based management of toxicities during chemotherapy did not result in fewer visits to the emergency department or hospital admissions. With the rapid rise in remote care because of the covid-19 pandemic, identifying scalable strategies for remote management of patients during cancer treatment is particularly relevant.

Trial registration

ClinicalTrials.govNCT02485678.
Sustained positive behaviour change of wounded, injured and sick UK military following an adaptive adventure sports and health coaching recovery course
Authors: Sutton Rebecca J , Kay C W P , McKenna J , Kaiseler M
Published: December 2021

Introduction

A rising trend has occurred in the physical and mental health challenges faced by recovering UK service personnel. To support these individuals, bespoke inclusive multiactivity and adventurous training courses (MAC) have been developed. This study investigated the MAC’s influence on participants’ ability to sustain day-to-day changes that facilitate positive mental health and psychological need satisfaction.

Methods

The 146 UK service personnel who participated in this study attended a five-day MAC 12 months ago. To investigate how the supportive experience influenced participants’ lives, quantitative and qualitative data were collected via an online survey. Open-ended questioning and abductive analysis were conducted to understand mechanisms, influential aspects of the course and positive behaviour change.

Results

Positive behaviour changes were reported by 74% of the respondents. These changes align with positive psychological well-being (98%). Impactful elements of the course experienced by participants mostly aligned with the three basic psychological needs of autonomy (34%), competence (36%) and relatedness (61%).

Conclusions

Recovery support programmes that encompass health coaching adventurous activities, such as the MAC, can initiate long-term positive behaviour change for recovering military personnel. In this specific context, the concurrence of the self-determination theory concepts that underpin the course delivery and participant outcomes is a powerful endorsement of implementation fidelity.
Effectiveness of decision aids on cancer-screening decision-making: an umbrella review protocol
Authors: Hibino Masaya , Hamashima Chisato , Iwata Mitsunaga , Terasawa Teruhiko
Published: December 2021

Introduction

Although systematic reviews have shown how decision aids about cancer-related clinical decisions improve selection of key options and shared decision-making, whether or not particular decision aids, defined by their specific presentation formats, delivery methods and other attributes, can perform better than others in the context of cancer-screening decisions is uncertain. Therefore, we planned an overview to address this issue by using standard umbrella review methods to repurpose existing systematic reviews and their component comparative studies.

Methods and analysis

We will search PubMed, Embase, the Cochrane Database of Systematic Reviews and the Database of Abstracts of Reviews of Effects from inception through 31 December 2021 with no language restriction and perform full-text evaluation of potentially relevant articles. We will include systematic reviews of randomised controlled trials or non-randomised studies of interventions that assessed a decision aid about cancer-screening decisions and compared it with an alternative tool or conventional management in healthy average-risk adults. Two reviewers will extract data and rate the study validity according to standard quality assessment measures. Our primary outcome will be intended and actual choice and adherence to selected options. The secondary outcomes will include attributes of the option-selection process, achieving shared decision-making and preference-linked psychosocial outcomes. We will qualitatively assess study, patient and intervention characteristics and outcomes. We will also take special care to investigate the presentation format, delivery methods and quality of the included decision aids and assess the degree to which the decision aid was delivered and used as intended. If appropriate, we will perform random-effects model meta-analyses to quantitatively synthesise the results.

Ethics and dissemination

Ethics approval is not applicable as this is a secondary analysis of publicly available data. The review results will be submitted for publication in a peer-reviewed journal.

Prospero registration number

CRD42021235957.
International guidelines for self-report and proxy completion of paediatric health-related quality of life measures: a protocol for a systematic review
Authors: Mpundu-Kaambwa Christine , Chen Gang , Dalziel Kim , Devlin Nancy , Ratcliffe Julie
Published: December 2021

Introduction

Measures of health-related quality of life (HRQoL), accompanied by the values (or utilities) required to estimate quality-adjusted life-years, are crucial for determining health benefits within economic evaluation and health technology assessment. Several generic and condition-specific measures or instruments of HRQoL, accompanied by values, currently exist for application with child populations. However, there is a lack of a structured summary of guidelines and recommendations for applying these measures in practice. This protocol describes a systematic review of guidelines and recommendations for child and proxy completion of child-specific measures of HRQoL. The aims of the review are to (1) identify and summarise published guidelines and recommendations for existing child-specific measures of HRQoL, (2) determine whether the identified guidelines and recommendations differ by instrument and child characteristics, (3) identify current gaps in these guidelines and recommendations and (4) identify best practices for child self and proxy assessment in paediatric HRQoL measurement for economic evaluation and health technology assessment.

Methods and analysis

The review will identify, collate and synthesise published guidelines and recommendations for existing child-specific utility measures of HRQoL. Electronic databases to be searched include the Cochrane Library, Medline, Scopus, Web of Science, EconLit, PsycINFO, CINAHL, Embase and Informit. The search will be extended to websites of (1) international organisations for health technology assessment, (2) regulation, health economics and HRQoL outcomes research and (3) instrument developers. Three reviewers will independently screen titles and abstracts against the inclusion criteria. A narrative synthesis will describe the key features of the guidelines identified.

Ethics and dissemination

Ethical approval is not required as the proposed systematic review will not use primary data. A paper of the systematic review will be submitted to a peer-reviewed journal for publication.

PROSPERO registration number

CRD42020207160.
Determining the effectiveness of cognitive behavioural therapy in improving quality of life in patients undergoing endometriosis surgery: a study protocol for a randomised controlled trial
Authors: Boersen Zoë , Oosterman Joukje , Hameleers Esther Gerdien , Delcliseur Heidi Sabine Mathilde Jeanne , Lutters Cobie , IJssel de Schepper Alicia , Braat Didi , Verhaak Christianne M , Nap Annemiek
Published: December 2021

Introduction

Endometriosis can cause chronic pain and subfertility thereby negatively affecting quality of life (QoL). Surgical removal of endometriosis lesions leads to improved health-related QoL, although not to the level of QoL of healthy controls. Pain intensity and cognitions regarding pain can play a crucial role in this health-related QoL following surgical treatment. Cognitive behavioural therapy (CBT) is a psychological treatment. In patients with chronic pain caused by a variety of medical conditions, CBT is effective in improving QoL. We designed a research protocol to investigate the effect of CBT on QoL in patients with endometriosis-associated chronic pain who are undergoing surgery.

Methods and analysis

This is a study protocol for a randomised controlled trial in which 100 patients, undergoing endometriosis removal surgery due to endometriosis-associated chronic pain, will be randomised between post-surgery usual care with CBT and post-surgery usual care only. Participants in the CBT group will additionally receive seven sessions of CBT, focused on expectancy management, cognitions regarding pain and emotional and behavioural impact of pain. To determine the primary outcome Quality of life, both groups will complete questionnaires assessing QoL. The secondary outcomes pain intensity, pain cognitions, fatigue and perceived stress are also measured using questionnaires. Additionally, a marker for stress (cortisol extracted from a hair sample) will be assessed at T0 (baseline assessment), T1 (post-intervention; 2 weeks after completion of all CBT sessions) and T2 (follow-up; 14 weeks after T1). Statistical analysis will be performed using SPSS software.

Ethics and dissemination

The study protocol has been approved by the Medical Ethical Committee of the region Arnhem-Nijmegen from the Radboud University Medical Centre on 2 September 2020. The findings of this study will be published in scientific journals and will be presented at scientific conferences.

Trial registration number

NCT04448366.
Surgery versus non-operative treatment for ER-stress unstable Weber-B unimalleolar fractures: a study protocol for a prospective randomized non-inferiority (Super-Fin) trial
Authors: Kortekangas Tero , Lehtola Ristomatti , Leskelä Hannu-Ville , Taimela Simo , Ohtonen Pasi , Savola Olli , Järvinen Teppo , Pakarinen Harri
Published: December 2021

Roughly two-thirds of ankle fractures are unimalleolar injuries, the Weber B-type fibula fracture being by far the most common type. Depending on the trauma and the accompanying soft-tissue injury, these fractures are either stable or unstable. Current clinical practice guidelines recommend surgical treatment for unstable Weber B-type fibula fractures. An ongoing randomized, parallel group, non-inferiority trial comparing surgery and non-operative treatment for unstable Weber B-type ankle fractures with allocation ratio 1:1. The rationale for non-inferiority design is as follows: By being able to prove non-inferiority of non-operative treatment, we would be able to avoid complications related to surgery. However, the primary concern related to non-operative treatment is increased risks of ankle mortise incongruency, leading to secondary surgery, early post-traumatic osteoarthritis and poor function. After providing informed consent, 126 patients aged 16 years or older with an unimalleolar Weber B-type unstable fibula fracture were randomly assigned to surgery (open reduction and internal fixation) or non-operative treatment (6-week cast immobilization). We have completed the patient enrolment and are currently in the final stages of the 2-year follow-up. The primary, non-inferiority outcome is the Olerud-Molander Ankle Score (OMAS) at 2 years (primary time point). The predefined non-inferiority margin is set at 8 OMAS points. Secondary outcomes include the Foot and Ankle Score, a 100 mm Visual Analogue Scale for function and pain, the RAND-36-Item Health Survey for health-related quality-of-life, the range-of-motion of the injured ankle, malunion (ankle joint incongruity) and fracture union. Treatment-related complications and harms; symptomatic non-unions, loss of congruity of the ankle joint, reoperations and wound infections will also be recorded. We hypothesize that non-operative treatment yields non-inferior functional outcome to surgery, the current standard treatment, with no increased risk of harms.
Humoral and cellular correlates of a novel immune-related adverse event and its treatment
Authors: Gonugunta Amrit S , von Itzstein Mitchell S , Mu-Mosley Hong , Fattah Farjana , Farrar J David , Mobely Angela , Rashdan Sawsan , Lai Sunny , Bhai Salman F , Bermas Bonnie L , Karp David , Li Quan-Zhen , Wakeland Edward K , Gerber David E
Published: December 2021

Immune-related adverse events (irAE) may affect almost any organ system and occur at any point during treatment with immune checkpoint inhibitors (ICI). We present a patient with advanced lung cancer receiving antiprogrammed death 1 checkpoint inhibitor who developed a delayed-onset visual irAE treated with corticosteroids. Through assessment of longitudinal biospecimens, we analyzed serial autoantibodies, cytokines, and cellular populations. Months after ICI initiation and preceding clinical toxicity, the patient developed broad increases in cytokines (most notably interleukin-6 (IL-6), interferon-γ (IFNγ), C-X-C motif chemokine ligand 2 (CXCL2), and C–C motif chemokine ligand 17 (CCL17)), autoantibodies (including anti-angiotensin receptor, α-actin, and amyloid), CD8 T cells, and plasmablasts. Such changes were not observed in healthy controls and ICI-treated patients without irAE. Administration of corticosteroids resulted in immediate and profound decreases in cytokines, autoantibodies, and inflammatory cells. This case highlights the potential for late-onset changes in humoral and cellular immunity in patients receiving ICI. It also demonstrates the biologic effects of corticosteroids on these parameters. Application of humoral and cellular immune biomarkers across ICI populations may inform toxicity monitoring and management.
Efficacy of anti-SARS-CoV-2 mRNA vaccine in systemic autoimmune disorders: induction of high avidity and neutralising anti-RBD antibodies
Authors: Tani Chiara , Pratesi Federico , Talarico Rosaria , Cardelli Chiara , Caruso Teresita , Di Cianni Federica , Laurino Elenia , Italiano Nazzareno , Moretti Michele , Manca Maria Laura , Migliorini Paola , Mosca Marta
Published: December 2021

Objectives

In patients with systemic autoimmune rheumatic disorders (SARDs), vaccination with SARS-CoV-2 mRNA vaccines has been proposed. The aim of this study is to evaluate the immune response elicited by vaccination with mRNA vaccine, testing IgM, IgA and IgG antibodies to SARS-CoV-2 receptor-binding domain (RBD) and measuring neutralising antibodies.

Methods

IgG, IgM and IgA anti-RBD antibodies were measured in 101 patients with SARDs. Antibodies inhibiting the interaction between RBD and ACE2 were evaluated. Antibody avidity was tested in a chaotropic ELISA using urea. Twenty-one healthcare workers vaccinated with mRNA vaccine served as control group.

Results

Anti-RBD IgG and IgA were produced after the first dose (69% and 64% of the patients) and after the boost (93% and 83%). Antibodies inhibiting the interaction of RBD with ACE2 were detectable in 40% of the patients after the first dose and 87% after boost, compared with 100% in healthy controls (p<0.01). Abatacept and mycophenolate had an impact on the titre of IgG anti-RBD antibodies (p<0.05 and p<0.005, respectively) and on the amount of neutralising antibodies. No effect of other therapies was observed. Vaccinated patients produce high avidity antibodies, as healthy controls.

Conclusions

These data show that double-dose vaccination induced in patients with SARDs anti-RBD IgG and IgA antibodies in amounts not significantly different from controls, and, most interestingly, characterised by high avidity and endowed with neutralising activity.
Effects of the COVID-19 pandemic on patients with inflammatory joint diseases in Sweden: from infection severity to impact on care provision
Authors: Bower Hannah , Frisell Thomas , di Giuseppe Daniela , Delcoigne Bénédicte , Alenius Gerd-Marie , Baecklund Eva , Chatzidionysiou Katerina , Feltelius Nils , Forsblad-d'Elia Helena , Kastbom Alf , Klareskog Lars , Lindqvist Elisabet , Lindström Ulf , Turesson Carl , Sjöwall Christopher , Askling Johan
Published: December 2021

Objectives

To compare risks for COVID-19-related outcomes in inflammatory joint diseases (IJDs) and across disease-modifying antirheumatic drugs (DMARDs) during the first two waves of the pandemic and to assess effects of the pandemic on rheumatology care provision.

Methods

Through nationwide multiregister linkages and cohort study design, we defined IJD and DMARD use annually in 2015–2020. We assessed absolute and relative risks of hospitalisation or death listing COVID-19. We also assessed the incidence of IJD and among individuals with IJD, rheumatologist visits, DMARD use and incidence of selected comorbidities.

Results

Based on 115 317 patients with IJD in 2020, crude risks of hospitalisation and death listing COVID-19 (0.94% and 0.33% across both waves, respectively) were similar during both waves (adjusted HR versus the general population 1.33, 95% CI 1.23 to 1.43, for hospitalisation listing COVID-19; 1.23, 95% CI 1.08 to 1.40 for death listing COVID-19). Overall, biological disease-modifying antirheumatic drugs (bDMARDs)/targeted synthetic disease-modifying antirheumatic drugs (tsDMARDs) did not increase risks of COVID-19 related hospitalisation (with the exception of a potential signal for JAK inhibitors) or death. During the pandemic, decreases were observed for IJD incidence (−7%), visits to rheumatology units (−16%), DMARD dispensations (+6.5% for bDMARD/tsDMARDs and −8.5% for conventional synthetic DMARDs compared with previous years) and for new comorbid conditions, but several of these changes were part of underlying secular trends.

Conclusions

Patients with IJD are at increased risk of serious COVID-19 outcomes, which may partially be explained by medical conditions other than IJD per se. The SARS-CoV-2 pandemic has exerted measurable effects on aspects of rheumatology care provision demonstrated, the future impact of which will need to be assessed.
Role of clinical and biochemical inflammation in structural progression of patients with psoriatic arthritis
Authors: Borst Carina , Alasti Farideh , Smolen Josef S , Aletaha Daniel
Published: December 2021

Objective

To determine the contribution of clinical and biochemical inflammation to structural progression of patients with psoriatic arthritis (PsA).

Methods

We analysed patients from the Infliximab Multinational Psoriatic Arthritis Controlled Trial 2 trial (infliximab vs placebo). We obtained total modified Sharp/van-der-Heijde Scores from baseline and year one images, and swollen joint counts (SJC) and levels of C reactive protein (CRP) throughout the second half of year 1 (5 measurements) from 74 placebo-treated patients. We computed radiographic progression, time-averaged SJC (taSJC) and CRP (taCRP) values and assessed their impact on structural progression by logistic regression analysis. We further categorised patients as ‘active’ (+) or ‘inactive’ (−) based on their taSJC (cut-off point: 2/66 joints) and taCRP (cut-off point: 0.5 mg/dL) and compared radiographic progression across three groups (double inactive, single active, double active).

Results

ORs for progression were 1.24 (95 % CI 1.04 to 1.47; p=0.016) for taSJC and 6.08 (95 % CI 1.12 to 33.03; p=0.036) for taCRP. When predictors were dichotomised (+ vs −), differences were maintained between taSJC+ and taSJC− patients (1.05±3.21 and 0.56±2.30, respectively), as well as for taCRP+ vs taCRP− patients (1.14±3.23 and 0.05±2.37, respectively). Progression was intermediate in the presence of abnormalities of one but not the other inflammatory variable, indicating increasing radiographic progression with increasing inflammation (p=0.05).

Conclusion

In patients with PsA, both clinical and biochemical inflammation have an impact on structural progression. Overall, progression is smallest in the absence of both clinical and biochemical inflammation, higher when either clinical or biochemical inflammation is present and highest with both clinical and biochemical inflammation.
Incidence, prevalence and risk of stroke in patients with Takayasu arteritis: a nationwide population-based study in South Korea
Authors: Ahn Sung Soo , Han Minkyung , Park Yong-Beom , Jung Inkyung , Lee Sang-Won
Published: December 2021

Background

Takayasu arteritis (TAK) is a disease associated with increased risk of cardiovascular complications. We aimed to evaluate the incidence, prevalence and risk of stroke in patients with TAK.

Methods

Data from 1065 patients were obtained from a national database (2010–2018). The annual incidence and prevalence per 100 000 persons were estimated using the registration population in the midst of every year, and the standardised incidence ratio (SIR) of stroke was compared with the general population based on the data from the 2006 national report for cardiovascular and cerebrovascular diseases. Age-adjusted incidence rate ratio (IRR) of stroke based on the time interval after diagnosis was also calculated. A time-dependent Cox regression was conducted to investigate predictive factors of stroke.

Results

The overall incidence rate of TAK ranged between 0.2 and 0.3/100 000 person-years annually; the prevalence of TAK gradually increased, reaching 3.25/100 000 person-years in 2018. Seventy-three (6.9%) patients experienced stroke during follow-up, and the risk of developing stroke was higher than the general population (overall SIR 7.39, 95% CI 5.79 to 9.29; men: SIR 5.70, 95% CI 2.84 to 10.20; women: SIR 7.06, 95% CI 5.41 to 9.05). Most stroke events (90.9%) were cerebral infarction for men, whereas the proportion of cerebral infarction was lower (62.9%) in women. Over half of stroke events occurred within 6 months after diagnosis, and stroke was more common within 6 months of diagnosis compared with after 3 years in women (IRR 13.46, 95% CI 6.86 to 26.40). In Cox regression analysis, age was the sole predictor of stroke (adjusted HR 1.02, 95% CI 1.00 to 1.04, p=0.043).

Conclusions

The annual incidence of TAK was similar to the previous studies from Asia, and the risk of stroke increased in TAK. Different patterns of subtype and incidence of stroke were found according to sex, although age was the only predictor.
Endovascular treatment with or without intravenous alteplase for acute ischaemic stroke due to basilar artery occlusion
Authors: Nie Ximing , Wang David , Pu Yuehua , Wei Yufei , Lu Qixuan , Yan Hongyi , Liu Xin , Zheng Lina , Liu Jingyi , Yang Xinxuan , Ding Yarong , Liu Dacheng , Duan Wanying , Zhang Zhe , Yang Zhonghua , Wen Miao , Gu Weibin , Hou Xinyi , Leng Xinyi , Pan Yuesong , Miao Zhongrong , Liu Liping
Published: December 2021

Background and purpose

It remains controversial if endovascular treatment (EVT) can improve the outcome of patients with acute basilar artery occlusion (BAO). This study aims to compare the functional outcomes between EVT with and without intravenous thrombolysis (IVT) first in patients who had acute ischaemic stroke (AIS) due to BAO.

Methods

Patients who had AIS with BAO who underwent EVT within 24 hours of onset were enrolled in this multicentre cohort study, and the efficacy and safety were compared between IVT+EVT and direct EVT. The primary outcome was 90-day functional independence. All outcomes were assessed with adjusted OR (aOR) from the multivariable logistic regression. In addition, a meta-analysis was performed on all recently published pivotal studies on functional independence after EVT in patients with BAO.

Results

Of 310 enrolled patients with BAO, 241 (78%) were treated with direct EVT and 69 (22%) with IVT+EVT. Direct EVT was associated with a worse functional outcome (aOR, 0.46 (95% CI 0.24 to 0.85), p=0.01). IVT+EVT was associated with a lower percentage of patients who needed ≥3 passes of stent retriever (10.14% vs 20.75%). The meta-analysis regression revealed a potential positive correlation between bridging with IVT first and functional independence (r=0.14 (95% CI 0.05 to 0.24), p<0.01).

Conclusions

This study showed that compared with direct EVT, EVT with IVT first was associated with better functional outcomes in patients with BAO treated within 24 hours of onset. The meta-analysis demonstrated similar favourable efficacy of IVT first followed by EVT in patients with BAO.
Late Cretaceous granitoids of the Sikhote–Alin orogenic belt, southeastern Russia: implications for the Mesozoic geodynamic history of the eastern Asian continental margin
Authors: Kemkin Igor V. , Grebennikov Andrei V. , Ma Xing-Hua , Sun Ke-Ke
Published: December 2021

We present new U–Pb age data for granitoids in the Central Sikhote–Alin orogenic belt in SE Russia, which refute the established opinion about the absence of the Late Cretaceous magmatism at the eastern margin of the Palaeo-Asian continent. It was previously thought that a period of magmatic quiescence occurred from 88 to 50 Ma, related to subduction of the Palaeo-Pacific plate under the eastern margin of the Palaeo-Asian continent, although this is inconsistent with evidence from the Sikhote–Alin, Sakhalin and Japan regions. Three suites of plutonic rocks with different ages were identified in this study. The first suite has ages of 105–92 Ma and formed in a syn-orogenic setting. The second (86–83 Ma) and third (
c.
73 Ma) suites formed during the post-orogenic stage of the Sikhote–Alin orogenic belt. The second and third suites were coeval with Late Cretaceous granitoids that formed in a supra-subduction continental arc known as the Eastern Sikhote–Alin volcanic–plutonic belt. However, the studied rocks are located far inland from the Eastern Sikhote–Alin volcanic–plutonic belt. The ages of the studied granitoids coincide with the timing of a change in the angle of convergence between the Palaeo-Pacific plate and eastern margin of the Palaeo-Asian continent. This change in motion of the oceanic plate with respect to the continental plate was probably caused by a rupture in the subducted slab (i.e. a slab tear), followed by asthenospheric upwelling and partial melting of the overlying crust, which ultimately generated post-orogenic intrusive magmatism.

Supplementary material:
Laser ablation–inductively coupled plasma–mass spectrometry zircon U–Pb data of the Bikin–Bol. Ussurka granitoid suites are available at
https://doi.org/10.6084/m9.figshare.c.5738616
Effect of pH and Al Cations on Chromate Inhibition of Galvanic-Induced Corrosion of AA7050-T7451 Macro-Coupled to 316SS
Authors: Charles-Granville Utibe-Eno , Glover Carol F. , Scully John R. , Kelly Robert G.
Published: December 2021

The performance of chromate in protecting AA7050-T7451 coupled to 316SS in simulated fastener environments, including those representative of the boldly exposed surfaces and downhole conditions, was investigated utilizing a number of electrochemical and surface characterization techniques. The influence of pH and Al3+ on the galvanic coupling behavior and damage evolution on AA7050 as a function of chromate concentration were assessed. The degree of chromate inhibition was observed to decrease as pH decreased, owing to chromate speciation and reduced capacity to suppress the hydrogen evolution reaction (HER) compared to the oxygen reduction reaction (ORR). The addition of 0.1 M Al3+ significantly increased HER kinetics and produced a large buffer effect which overwhelmed the ability of chromate to slow damage propagation on AA7050. Assessment of cathodes indicated that Cu was more important than 316SS in driving damage initiation, but less active than 316SS in supporting high-rate damage propagation in simulated crevice environments. The implications of this study for actual bimetallic systems are discussed.
Breviscapine Participates in the Progression of Prostate Cancer by Inhibiting ZFP91 Expression through Upregulation of MicroRNA-129-5p
Authors: Yang Jie , Jin Wanjun , Zhang Xiaokang , Chang Pengcheng , Zheng Duo
Published: December 2021

Objective. To investigate the effect of breviscapine (BVP) on the development of prostate cancer and its molecular mechanism. Materials and Methods. After treatment with breviscapine and microRNA-129-5p, MTT (3-(4,5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide) and cell counting kit-8 (CCK-8) tests were performed to examine the proliferation rate of cells, while Transwell was used to analyze cell migration ability; at the same time, quantitative real-time polymerase chain reaction (qRT-PCR) was applied to detect the expression of microRNA-129-5p and ZFP91 in prostate cancer cells. In addition, the binding of microRNA-129-5p and ZFP91 was confirmed by dual-luciferase reporting assay; meanwhile, cell reverse experiment verified that breviscapine can regulate ZFP91 via upregulating microRNA-129-5p. Results. The results of MTT, CCK-8, and Transwell experiments demonstrated that breviscapine inhibited the proliferation as well as the migration capacities of PC cells; meanwhile, it upregulated the level of microRNA-129-5p in PC cells while downregulated that of ZFP91. Furthermore, dual-luciferase reporter gene assay verified that ZFP91 was a potential target of microRNA-129-5p. Finally, cell reverse experiment confirmed that breviscapine downregulated ZFP91 expression by upregulating microRNA-129-5p, while downregulation of microRNA-129-5p partially reversed the inhibitory effect of breviscapine on cell proliferation ability. Conclusions. Breviscapine may inhibit the expression of ZFP91 through upregulating microRNA-129-5p and thus participating in the progression of PC.
Tert-Butylhydroquinone Prevents Oxidative Stress-Mediated Apoptosis and Extracellular Matrix Degradation in Rat Chondrocytes
Authors: Yang Bo , Huang Haisheng , He Qisong , Lu Wei , Zheng Lu , Cui Li
Published: December 2021

Oxidative stress-induced chondrocyte apoptosis and degradation of the extracellular matrix (ECM) play an important role in the progression of osteoarthritis (OA). In addition, tert-butylhydroquinone (TBHQ) is an activator of the nuclear factor erythroid derived-2-related factor 2 (Nrf2). The present study aimed to determine the effectiveness of TBHQ in preventing the apoptosis of chondrocytes and degradation of the extracellular matrix, induced by oxidative stress, in vitro. Therefore, rat chondrocytes were exposed to 20 μM tert-butyl hydroperoxide (TBHP) for 24 h to establish an oxidative damage model, in vitro. Thereafter, cell viability was evaluated using the Cell Counting Kit-8 assay. Moreover, the level of ROS was determined through 2′,7′-dichlorofluorescein diacetate staining. The mitochondrial membrane potential of chondrocytes was also measured using JC-1. Furthermore, cell apoptosis was assessed through Annexin V-fluorescein isothiocyanate/propidium iodide staining. The study also performed Western blotting and qPCR to evaluate the expression of extracellular matrix components, matrix catabolic enzymes, and changes in signalling pathways. The results showed that 2.5 and 5 μM of TBHQ reduced the TBHP-induced generation of excessive ROS and improved cell viability. Additionally, 2.5 and 5 μM of TBHQ prevented mitochondrial damage and apoptosis in rat chondrocytes. Treatment with TBHQ also increased the mRNA and protein expression levels of aggrecan and collagen II. However, TBHQ reduced the mRNA and protein expression levels of matrix metalloproteinase 3 (MMP3) and matrix metalloproteinase 13 (MMP13) in rat chondrocytes. In addition, treatment with TBHQ enhanced the protein expression levels of Nrf2, NADPH quinone oxidoreductase 1 (NQO-1), and hemeoxygenase-1 (HO-1) in rat chondrocytes. The current study showed that TBHQ was not only effective in protecting against TBHP-induced oxidative stress but also inhibited the apoptosis of rat chondrocytes and degradation of the ECM by activating the Nrf2 pathway. The results therefore suggest that TBHQ holds potential for use in the treatment of OA.
Mechanism of Acupuncture and Moxibustion on Chronic Prostatitis/Chronic Pelvic Pain Syndrome: A Narrative Review of Animal Studies
Authors: Wu Xiaoling , Cheng Kai , Xu Chang , Liu Shaoming , Sun Qianhui , Yang Zhiwen , Dai Xingye , Li Na
Published: December 2021

Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a genitourinary disease commonly seen in males, with symptoms involving pelvic pain, urinary system disease, and sexual dysfunction, which seriously affects physical and mental health, and it also influences the quality of life of patients. At present, the disease’s aetiology and pathogenesis are unclear, and there is also no effective treatment for it. Acupuncture and moxibustion have been a way to CP/CPPS, showing good curative effect with advantages of safety and affordability. However, the relevant research in this field is less discussed. By adopting databases, such as CNKI, VIP, Wanfang, PubMed, and Medline, this review article used keywords including chronic prostatitis, chronic pelvic pain syndrome, and electric acupuncture, manual acupuncture, moxibustion, and animal experiments, rats, mice, and mechanism research and reviewing research papers published from 1998 to 2021. Then, it further summarized and evaluated the mechanism research and gave a brief comment about modeling methods, acupoints selection, and stimulus parameters that have been used in the selected research papers. Equally important, this review article proposes a reference for the in-depth study of the mechanism of acupuncture and moxibustion on CP/CPPS and provides a theoretical basis to better treat the disease in the clinic.
Liquefaction Evaluation Based on Shear Wave Velocity Using Random Forest
Authors: Liu Lu , Zhang Shushan , Yao Xiaofei , Gao Hongmei , Wang Zhihua , Shen Zhifu
Published: December 2021

Liquefaction evaluation on the sands induced by earthquake is of significance for engineers in seismic design. In this study, the random forest (RF) method is introduced and adopted to evaluate the seismic liquefaction potential of soils based on the shear wave velocity. The RF model was developed using the Andrus database as a training dataset comprising 225 sets of liquefaction performance and shear wave velocity measurements. Five training parameters are selected for RF model including seismic magnitude (Mw), peak horizontal ground surface acceleration (amax), stress‐corrected shear wave velocity of soil (Vs1), sandy‐layer buried depth (ds), and a new introduced parameter, stress ratio (k). In addition, the optimal hyperparameters for the random forest model are determined based on the minimum error rate for the out‐of‐bag dataset (ERROOB) such as the number of classification trees, maximum depth of trees, and maximum number of features. The established random forest model was validated using the Kayen database as testing dataset and compared with the Chinese code and the Andrus methods. The results indicated that the random forest method established based on the training dataset was credible. The random forest method gave a success rate for liquefied sites and even a total success rate for all cases higher than 80%, which is completely acceptable. By contrast, the Chinese code method and the Andrus methods gave a high success rate for liquefaction but very low for nonliquefaction which led to the increase of engineering cost. The developed RF model can provide references for engineers to evaluate liquefaction potential.
Fast CU Size Decision Method Based on Just Noticeable Distortion and Deep Learning
Authors: Zhao Jinchao , Wang Yihan , Zhang Qiuwen
Published: December 2021

With the development of broadband networks and high-definition displays, people have higher expectations for the quality of video images, which also brings new requirements and challenges to video coding technology. Compared with H.265/High Efficiency Video Coding (HEVC), the latest video coding standard, Versatile Video Coding (VVC), can save 50%-bit rate while maintaining the same subjective quality, but it leads to extremely high encoding complexity. To decrease the complexity, a fast coding unit (CU) size decision method based on Just Noticeable Distortion (JND) and deep learning is proposed in this paper. Specifically, the hybrid JND threshold model is first designed to distinguish smooth, normal, or complex region. Then, if CU belongs to complex area, the Ultra-Spherical SVM (US-SVM) classifiers are trained for forecasting the best splitting mode. Experimental results illustrate that the proposed method can save about 52.35% coding runtime, which can realize a trade-off between the reduction of computational burden and coding efficiency compared with the latest methods.
Screening for FMR1 CGG Repeat Expansion in Thai Patients with Autism Spectrum Disorder
Authors: Hnoonual Areerat , Jankittunpaiboon Charunee , Limprasert Pornprot
Published: December 2021

Autism spectrum disorder (ASD) is a complex disorder with a heterogeneous etiology. Fragile X syndrome (FXS) is recognized as the most common single gene mutation associated with ASD. FXS patients show some autistic behaviors and may be difficult to distinguish at a young age from autistic children. However, there have been no published reports on the prevalence of FXS in ASD patients in Thailand. In this study, we present a pilot study to analyze the CGG repeat sizes of the FMR1 gene in Thai autistic patients. We screened 202 unrelated Thai patients (168 males and 34 females) with nonsyndromic ASD and 212 normal controls using standard FXS molecular diagnosis techniques. The distributions of FMR1 CGG repeat sizes in the ASD and normal control groups were similar, with the two most common alleles having 29 and 30 CGG repeats, followed by an allele with 36 CGG repeats. No FMR1 full mutations or premutations were found in either ASD individuals or the normal controls. Interestingly, three ASD male patients with high normal CGG and intermediate CGG repeats (44, 46, and 53 CGG repeats) were identified, indicating that the prevalence of FMR1 intermediate alleles in Thai ASD patients was approximately 1% while these alleles were absent in the normal male controls. Our study indicates that CGG repeat expansions of the FMR1 gene may not be a common genetic cause of nonsyndromic ASD in Thai patients. However, further studies for mutations other than the CGG expansion in the FMR1 gene are required to get a better information on FXS prevalence in Thai ASD patients.
A Random Walk with Restart Model Based on Common Neighbors for Predicting the Clinical Drug Combinations on Coronary Heart Disease
Authors: Che Yushi , Cheng Wei , Wang Yiqiao , Chen Dong
Published: December 2021

As the approaching of the clinical big data era, the prediction of whether drugs can be used in combination in clinical practice is a fundamental problem in the analysis of medical data. Compared with high-throughput screening, it is more cost-effective to treat this problem as a link prediction problem and predict by algorithms. Inspired by the rule of combined clinical medication, a new computational model is proposed. The drug-drug combination was predicted by combining the number of adjacent complete subgraphs shared by the two points with the restart random walk algorithm. The model is based on the semisupervised random walk algorithm, and the same neighborhood is used to improve the random walk with restart (CN-RWR). The algorithm can effectively improve the prediction performance and assign a score to any combination of drugs. To fairly compare the predictive performance of the improved model with that of the random walk with restart model (RWR), a cross-validation of the two models on the same drug data was performed. The AUROC of CN-RWR and RWR under the LOOCV validation framework is 0.9741 and 0.9586, respectively, and the improved model results are more reliable. In addition, the top 3 predictive drug combinations have been approved by the public. The new model is expected that this model can be extended to predict the use of combination drugs for other diseases to find combinations of drugs with potential clinical benefits.
Differential Evolution Algorithm‐Based Iterative Sliding Mode Control of Underactuated Ship Motion
Authors: Yan Huaran , Xiao Yingjie , Li Qinrong , Wang Renqiang
Published: December 2021

The differential evolution algorithm (DEA)‐based iterative sliding mode control (ISMC) method was proposed for the path tracking problem of three‐degree‐of‐freedom (3‐DoF) underactuated ships under external interference, with the nonlinear separate model proposed by mathematical model group (MMG). To improve control quality and enhance robustness of the control system, a swarm intelligence optimization algorithm is used to design a controller parameter optimization system. The DEA was adopted in the system to solve the minimum system evaluation index function, and the optimal controller parameters are acquired. Considering the impact of chattering on the actual project, a chattering measurement function is defined in the controller design and used as an input of the controller parameter optimization system. Finally, the 5446TEU container ship is carried out for simulation. It is verified that the designed controller with strong robustness can effectively deal with the disturbances; meanwhile, the chattering of the output is significantly reduced, and the control rudder angle signal conforms to the actual operation requirements of the ship and is more in line with the engineering reality.
[Retracted] A Novel Smart Healthcare Monitoring System Using Machine Learning and the Internet of Things
Authors: Alazzam Malik Bader , Alassery Fawaz , Almulihi Ahmed
Published: December 2021

The Internet of Things (IoT) has enabled the invention of smart health monitoring systems. These health monitoring systems can track a person’s mental and physical wellness. Stress, anxiety, and hypertension are key causes of many physical and mental disorders. Age‐related problems such as stress, anxiety, and hypertension necessitate specific attention in this setting. Stress, anxiety, and blood pressure monitoring can prevent long‐term damage by detecting problems early. This will increase the quality of life and reduce caregiver stress and healthcare costs. Determine fresh technology solutions for real‐time stress, anxiety, and blood pressure monitoring using discreet wearable sensors and machine learning approaches. This study created an automated artefact detection method for BP and PPG signals. It was proposed to automatically remove outlier points generated by movement artefacts from the blood pressure signal. Next, eleven features taken from the oscillometric waveform envelope were utilised to analyse the relationship between diastolic blood pressure (SBP) and systolic blood pressure (DBP). This paper validates a proposed computational method for estimating blood pressure. The proposed architecture leverages sophisticated regression to predict systolic and diastolic blood pressure values from PPG signal characteristics.
Migration, Distribution, and Safety Evaluation of Specific Phenotypic and Functional Mouse Spleen-Derived Invariant Natural Killer T2 Cells after Adoptive Infusion
Authors: Chen Dongzhi , Xu Wenbin , Teng Jingfang , Liu Huifang , Wang Yuanyuan , Wang Yan , Cheng Shujie , Meng Ming
Published: December 2021

Herein, the migration distribution and safety of specific phenotypic and functionally identified spleen-derived invariant natural killer T2 (iNKT2) cells after adoptive infusion in mice were studied. The proliferation and differentiation of iNKT cells were induced by intraperitoneal injection of α-galactosylceramide (α-GalCer) in vivo. Mouse spleens were isolated in a sterile environment. iNKT cells were isolated by magnetic-activated cell sorting columns (MS columns). Cytometric bead array (CBA) assay was used to detect cytokine secretion in the supernatant stimulated by iNKT cells. The basic life status of the mice was observed, and systematic quantitative scoring was conducted after injecting spleen-derived iNKT cells through the tail vein. An in vivo imaging system was used to trace the migration and distribution of iNKT cells in DBA mice. The percentage of the iNKT2 subgroup was the highest in 3 days after intraperitoneal injection of α-GalCer, and iNKT2 subsets accounted for more than 92% after separation and purification by magnetic-activated cell sorting (MACS). Anti-inflammatory cytokine IL-4 was mainly found in the supernatant of cell cultures. The adoptive infusion of iNKT cells into healthy mice resulted in no significant change in the basic life status of mice compared with the noninjected group. iNKT cells were detected in the lung, spleen, and liver, but no fluorescence was detected in lymph nodes and thymus. After dissecting the mice, it was found that there were no significant abnormalities in the relevant immune organs, brain, heart, kidney, lung, and other organs. Intraperitoneal injection of α-GalCer results in a large number of iNKT2 cells, mainly secreting anti-inflammatory cytokine IL-4, from the spleen of mice. After adoptive infusion, the iNKT2 cells mainly settled in the liver and spleen of mice with a satisfactory safety profile.