bluuebunny/crossref_metadata_2025 huggingface dataset:
Empagliflozin Improves Insulin Sensitivity of the Hypothalamus in Humans With Prediabetes: A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Trial
Authors: Kullmann Stephanie , Hummel Julia , Wagner Robert , Dannecker Corinna , Vosseler Andreas , Fritsche Louise , Veit Ralf , Kantartzis Konstantinos , Machann Jürgen , Birkenfeld Andreas L. , Stefan Norbert , Häring Hans-Ulrich , Peter Andreas , Preissl Hubert , Fritsche Andreas , Heni Martin
Published: October 2021

OBJECTIVE

Insulin action in the human brain reduces food intake, improves whole-body insulin sensitivity, and modulates body fat mass and its distribution. Obesity and type 2 diabetes are often associated with brain insulin resistance, resulting in impaired brain-derived modulation of peripheral metabolism. So far, no pharmacological treatment for brain insulin resistance has been established. Since sodium–glucose cotransporter 2 (SGLT2) inhibitors lower glucose levels and modulate energy metabolism, we hypothesized that SGLT2 inhibition may be a pharmacological approach to reverse brain insulin resistance.

RESEARCH DESIGN AND METHODS

In this randomized, double-blind, placebo-controlled clinical trial, 40 patients (mean ± SD; age 60 ± 9 years; BMI 31.5 ± 3.8 kg/m2) with prediabetes were randomized to receive 25 mg empagliflozin every day or placebo. Before and after 8 weeks of treatment, brain insulin sensitivity was assessed by functional MRI combined with intranasal administration of insulin to the brain.

RESULTS

We identified a significant interaction between time and treatment in the hypothalamic response to insulin. Post hoc analyses revealed that only empagliflozin-treated patients experienced increased hypothalamic insulin responsiveness. Hypothalamic insulin action significantly mediated the empagliflozin-induced decrease in fasting glucose and liver fat.

CONCLUSIONS

Our results corroborate insulin resistance of the hypothalamus in humans with prediabetes. Treatment with empagliflozin for 8 weeks was able to restore hypothalamic insulin sensitivity, a favorable response that could contribute to the beneficial effects of SGLT2 inhibitors. Our findings position SGLT2 inhibition as the first pharmacological approach to reverse brain insulin resistance, with potential benefits for adiposity and whole-body metabolism.
Risk Factors for Diabetic Peripheral Neuropathy in Adolescents and Young Adults With Type 2 Diabetes: Results From the TODAY Study
Authors: Katz Lorraine E. Levitt , White Neil H. , ghormli Laure El , Chan Christine L. , Copeland Kenneth C. , Lipman Terri H. , Marcus Marsha D. , Zeitler Philip , Group the TODAY Study
Published: October 2021

Objective:
Data related to diabetic neuropathy in youth with type 2 diabetes are limited. We examined the relationship of glycemic
control, sex, race-ethnicity, BMI, and other type 2 diabetes-associated factors
with the development of diabetic peripheral neuropathy (DPN) in type 2 diabetes
youth enrolled in the Treatment Options for type 2
Diabetes in Adolescents and Youth (TODAY) study.

Research
Design and Methods: The Michigan
Neuropathy Screening Instrument (MNSI) and a 10-gram monofilament exam were performed
annually. DPN was defined as a score (>2) on the MNSI-exam or combined
MNSI-exam and MNSI-survey scores (exam >2 and/or survey ≥4), or monofilament
(<8/10 correct responses) at 2 or more consecutive visits. Multivariable time-to-event
models assessed the association of risk factors evaluated longitudinally with DPN
events.

Results: 674
participants (35% male), with mean age 14 years and diabetes duration <2
years at study entry were evaluated annually over an average of 10.2 years. Males
had a significantly higher cumulative incidence of DPN than females (38.5% vs. 27.2% via MNSI-exam, p=0.002; 14.0%
vs. 5.1% via monofilament, p=0.01). Rates did not differ by race-ethnicity.
Higher HbA1c and BMI were associated with higher DPN, by both MNSI and
monofilament. In multivariable models, male sex, older age, and higher BMI were
associated with MNSI-exam DPN risk.

Conclusions: DPN was evident early
in the course of youth-onset type 2 diabetes and increased
over time. It was higher in males and related to glycemic control. These
findings raise concern for long-term development of neuropathy-related morbidity
in youth with type 2 diabetes and the need to achieve improved glycemic
control.
Research on the Teacher Training Mode of Innovation Practice Education for Mechanical Majors
Authors:   School of Mechanical & Automotive Engineering, Qilu University of Technology (Shandong Academy of Sciences), Daxue Road, Jinan, China, Li Chunling , Lu Yufeng ,   Shandong Institute of Mechanical Design and Research, Jinan, China
Published: October 2021

One of the goals of higher education teaching reform in China is to cultivate college students' innovative and practical ability. A professional and excellent teachers’ team is very important to innovation practice education. The problems in teacher training were analyzed according to the present situation of innovation practice education in universities. The teacher training mode of innovation practice education for mechanical majors was explored. Results showed that teachers' innovative and practical teaching ability has been greatly improved.
Association of Foods with Hypertension: A Call for Action
Authors: Samdani Khubaib , Rasool Faiz , Azhar Saad , Akhtar Zarish , Hassan Sarmad , Khan Tayyab Mumtaz , Mansoor Sana , Mumtaz Madeeha , Khan Sharukh
Published: October 2021

Hypertension (HTN) is a very prevalent health issue around the world. Many factors influence HTN and some of those include diabetes, obesity, gender, age, and diet. Impact of diet on hypertension, is understudied in our region, therefore, this study was set to manifest the effect of diet on HTN prevalence. This cross-sectional study was performed among local Islamabad of population, Pakistan in 3 months from November 2019 to January 2020. 138 people were recruited in study via a developed criterion. Data was collected by self-designed proforma. Data analysis was done by applying IBM SPSS version 25. Descriptive statistics were used for quantitative variables. As data was non-parametric, so we applied non-parametric statistical tests like Mann Whitney test, Kruskal–Wallis test and Spearman correlation analysis were applied to assess, the difference in means of both systolic and diastolic BP between female and male, difference in means of both systolic and diastolic BP among three consumption frequency levels, and association, direction, and strength of between HTN and foods consumption. Present study indicates overall high prevalence of HTN (39.86%) among study population. Means of age, systolic and diastolic BP for study population were 43.42 (with SD of ±8.30) years, 138.01mmHg (with SD of ±19.37), and 89.38mmHg (with SD of ±7.10) respectively. Difference in means of both systolic and diastolic between females and males was not significant (p=0.093 and p=0.078 respectively) although these were higher among males and gender was not associated with HTN significantly (p=0.069). Strength and direction for association between fast food and HTN was strong and positive, for association between snack food and HTN was strong and positive while for association between fresh fruits and raw vegetables was strong and negative with correlation coefficients (+0.690 for diastolic, +0.710 for systolic), (+0.651 for diastolic, +0.661 for systolic), (-0.712 for diastolic, -0.712 for systolic) respectively. In short, present study concludes that HTN was more prevalent among males, fast food, snack foods eaters and fresh fruits and raw vegetables non-eater in contrast to females, fresh fruits and raw vegetables eaters and non-eaters of fast foods and snack foods. Higher consumption of fast foods and snack lead to higher prevalence of HTN and vice versa whereas higher consumption of fresh fruits and raw vegetables bring decline in the incidence of HTN incidence and vice versa. So, we are dependent on awareness among people about the influence of food on HTN and gender specific measures for each gender to reduce HTN incidence.
Acyanotic Truncus Arteriosus Type 4 in a Sudden Infant Death: A Case Report
Authors: Razak Nadiawati , Yih Lee Jiun , Zainun Khairul Anuar
Published: October 2021

A congenital cyanotic heart defect such as Truncus Arteriosus (TA) is rare and is represented by a single arterial trunk that develops from the heart and gives rise to the pulmonary trunk in several manners. TA comprises 0.7% of all complex congenital heart malformations caused by numerous aetiologies, with the majority being genetic in origin. This malformation can be recognised in the prenatal period so that further medical intervention can be advocated. There are four types of the defect based on the Collett-Edwards classification. Type 4 is a rare form in which the pulmonary arteries are non-existent. Therefore, the lungs are supplied by major aortopulmonary collateral arteries. It may also describe this anatomical picture as pulmonary atresia with VSD. We report here a unique case of truncus arteriosus type 4 in an apparently well-thriving and acyanotic 6-month-old male infant. The deceased was presented with a brief history of inconsolable cry shortly before his demise and the underlying cardiac abnormalities were discovered at autopsy. A meticulous post-mortem examination elucidates a better diagnosis approach. Genetic counselling can be offered to parents in recurrent cases, such as cases of consanguinity.
Psychopathology of Dementia: Psychology’s Pivotal Role
Authors: Garrett Mario Dominic
Published: October 2021

Biology does not completely explain dementia. We can neither predict nor confirm a diagnosis of dementia based purely on its biology. Recent studies looking at prevention using social interventions hold better promise for ameliorating the disease. Yet, we do not have a major theory to explain these outcomes without resorting to biology. By understanding that there are mediating and moderating psychological factors promoting dementia, we take a broader view of the disease than a simple binary approach. Psychology plays a vital role in this clinical disease, in how cognition affects dementia. The presumption is that all of cognition: perception, orientation, novelty, attention, the application of knowledge (praxis), calculation, language, abstract thinking, and memory can affect and bring about dementia. It is not dementia that causes cognitive decline but cognitive decline that causes dementia. The psychopathology of dementia can initiate dementia, moderate it by enhancing or retarding the progression of the disease or mediate the disease by acting as a confirmatory process. The tipping point expressed by apathy and depression heralds a change in cognition. The psychopathology of dementia is important in understanding the etiology of dementia as it holds the most promising avenue for curing some dementias.
Study on Effectiveness of Kaltenborn Mobilization Techniques Grade III in Patient with Frozen Stage of Adhesive Capsulitis of Shoulder Joint
Authors: Rezwan A. K. M. , Shahriar T. M. , Rasal A. N. M. , Rahman M. , Haque T. , Sharmin N. A.
Published: October 2021

Background: Frozen shoulder is the stage II of adhesive capsulitis characterized by progressive loss of shoulder movement and symptoms of pain, decrease joint range of motion.

Objective: To determine the effectiveness of kaltenborn mobilization technique grade-III to the treatment of frozen stage of adhesive capsulitis of shoulder joint.

Methods: This quasi-experimental study in total number of 40 respondent were diagnosed with frozen stage of adhesive capsulitis of shoulder joint and randomly allocated into 2 groups. Within both group (n=20) & experimental group were treated by kaltenborn mobilization technique grade III whereas control group were treated by routine physiotherapy treatment and apply one session per day for four weeks. Outcome measures used were Visual analog scale (VAS) and Shoulder disability questioner (SDI). Paired ‘t’-tests was used to compare the pre and posttest value of treatment within both groups. Participants were selected based on the inclusion and exclusion criteria.

Statistics & Results: Data was collected on a data sheet & encoded for computerized analysis using SPSS version 19. The statistical analysis of post values of Group A (Kaltenborn mobilization technique grade III) where VAS mean of pretest (6.90 ± 1.02) and posttest (4.35 ± 1.60) value where (p < 0.0001). SDI mean of pretest (4.1±1.45) and posttest (2.9 ±1.20) value where (p < 0.0002). In group B (Routine physiotherapy treatment) where VAS mean of pretest (6.75 ± 1.07) and posttest (6.25 ± 1.06) value where (p < 0.0003). SDI mean of pretest (4.1±1.45) and posttest (3.5 ±0.49) value where (p < 0.0077).

Conclusion: It was concluded that both techniques were effective but kaltenborn mobilization techniques grade III was more effective then routine physiotherapy technique.
Comparison of Body Mass Index and Cholelithiasis Diagnosed on Ultrasound in the Population of Pindi Bhattian
Authors: Mehmood I. , Uzair M. , Malik A. , Gillani Y. , Shahwar D. E. , Illayas Z. , Fatima N.
Published: October 2021

Obesity is one of the emerging conditions in our population. Gallstones are composed of cholesterol. It is postulated that gallstones are associated with the deposition of cholesterol. Ultrasound is the first line imaging modality for the diagnosis of cholelithiasis. If gallstones are correlated with BMI, it will open up a new vista for further research.
In Yaqoob Ultrasound Clinic, PindiBhattian, Pakistan, a cross sectional analytical study was conducted. All included patients were inquired regarding variables like Age, Height, Weight, Presences of stones, Wall thickness of gall bladder, and location of gall stones on grey scale ultrasound findings. Patients were asked to lie down and expose their abdomen; grey scale abdominal ultrasound was performed of these patients. All variables mentioned above for each patient was recorded and maintain in their individual case record form (CFR). Data was collected during allocated period. Statically package SPSS version 2.4 was used to check the collected data and to organize and compile results. According to results out of total 160 patients, 105 were females and 55 were male. Out of 160 patients 150 (93.8%) were present with gall stones and 10 (6.3%) were having no gall stone. In total 61 patients (38.1%) were having single gall stone whereas 89 (55.6%) were diagnosed with multiple gall stones. According to the results, minimum age was 18 years and maximum was 80 years. Our study concluded that obesity is one of the major risk factors for gall stones. Obesity is usually more common in females, so they are more likely to have gall stones and overweight patients were more prone to GB stones.
Gas mixture explosion as a tool for generating impulsive disturbances
Authors: Polyakovskyi V.A.
Published: October 2021

The work is devoted to the development of a device for generating impulsive perturbations in soil massifs. It is proposed to use the explosion energy of a high-pressure acetylene-oxygen gas mixture as a source of impulse perturbations. Applying the standard method of measuring mechanical stresses and using piezoelectric sensors, it is obtained the stress fields occurring in the soils when an explosion of the gas mixture takes place. It is revealed that the dependences of the maximal stresses in the soil massif on the relative distance to the source, when the gas charge under high pressure acts, are the power functions. The exponents of power functions approximating these experimental dependences are obtained. The attenuation of the maximal radial stresses with the distance is considered for the two cases when the charges filled with gas mixture under low and high pressure act. The comparison of these cases indicates their similarity. In the paper it is also performed the analysis of modern methods of using explosive and non-explosive sources for seismic wave generation during investigations in the search geophysics. The existing structural sources of seismic waves used in the seismic exploration are analyzed in detail. The disadvantages and advantages of explosive and non-explosive impulsive sources of seismic waves are indicated. Among the advantages of the proposed wave sources it is worth noting their low price and mobility. There is no need to obtain special permits for their use. The obtained results allow one to expand the field of gas detonation application. In particular, it can be used as an alternative source of seismic waves. The proposed method is promising for training in search geophysics and in the study of properties of soil massifs.
The Differences in Body Image in terms of Gender, Cultural Background, and Students Admission Path
Authors: Yuca Verlanda , Zahri Triave Nuzila , Magistarina Elrisfa
Published: October 2021

As a part of physiological needs, human physical appearance is considered an essential part of people's lives. That integral part determines the formation of body image in the community. Body image is a mental picture of the body state. The development of student body image is not well-formed, so that it affects their life. In the lecture process, students tend to be inactive and have low self-esteem, which impact student life. Some factors that affect the body image are gender, cultural background, and the admission way. This study aims to describe the body image in terms of gender, cultural background, student's admission way, and the group's interaction. This study used a descriptive comparative method with 600 samples—the data collection using Yuca Puji Body-Image Inventory (YPBI) and ANOVA as an analyzing tool. The result shows significant differences in body image in terms of gender, cultural background, and admission. The results of this research can prove that student can develop body image in a positive direction. This result of the study will be used as a basic concept to determine a body image module.
Zoom breakout room for students’ collaborative skill enhancement in history learning during Covid-19 outbreak
Authors: Agustina Ema , Suharya Toto
Published: October 2021

The new transformation in history learning is needed in online learning, especially when it comes to improving students’ collaborative skills in solving problems, finding solutions, making decisions, and negotiating to achieve particular goals in 21st-century learning skills. Virtual learning rooms such as Zoom are used to ensure students’ involvement and collaboration in learning and provide opportunities for students to realize active learning with many features that can be applied. Despite many studies that have portrayed virtual learning with Zoom during the COVID-19 pandemic, fewer studies seek the utilization of Zoom Breakout Room in history learning. This study uncovered how teachers enhance students’ collaborative skills in history learning through the Zoom Breakout Room. The current study employed the qualitative approach under the case study design. In-depth interviews were directly conducted with one history teacher who was experienced in working history learning with Zoom Breakout Room to obtain the empirical data. The results showed that Teachers could use the zoom Breakout Room to improve students’ collaborative skills. In the current study, the Zoom Breakout Room, as one of the innovative tools in the Virtual Learning Environment (VLE) answered the ineffective learning with large groups in Zoom main room discussion. The breakout Room feature in Zoom itself supported an active learning process. The students are given more space to communicate in small groups and seek information, discuss, solve problems, and make collective agreements. The Zoom Breakout Room could be an alternative for teachers in facing learning challenges amid the COVID-19 outbreak.
Kindergarten principal leadership and academic supervision of supervisors as contributing factors to kindergarten teacher performance
Authors: Hafnizar Hafnizar , Daharnis Daharnis , Putra Febri Wandha
Published: October 2021

Research based on phenomena that show a decline in teacher performance. The purpose of this study was to describe the contribution of kindergarten principal leadership and academic supervision to performing kindergarten teachers. This type of research is quantitative, with a descriptive correlational approach. The population in this study were kindergarten teachers, amounting to 43 people. Respondents in this study amounted to 43 people. The instrument used is a Likert model scale and a questionnaire about teacher performance, the leadership of the kindergarten principal, and the academic supervision of the education unit supervisor. Test the validity using the product moment correlation. For the reliability test using Cronbach’s alpha. The requirements analysis tests carried out are; normality test, linearity test and multicollinearity test. The data analysis technique used simple regression and multiple regression. The results showed that; 1) there is a contribution from the leadership of the kindergarten head to performing the kindergarten teacher, 2) there is the contribution of the academic supervision of the education unit supervisor to the kindergarten teacher’s performance, and 3) there is the contribution of the leadership of the kindergarten head and the academic supervision of the education unit supervisor to the kindergarten teacher performance.
PROFILE OF MALIGNANT IN CHILDREN OF VINNITSIA REGION, CLINICAL EXPERIENCE
Authors: Rubina O. , Kulik J. , Моravska О. , Bеrtsun К. , Homon R.
Published: October 2021

Introduction. The structure of cancer incidence inchildren has its own characteristics. The majority of tumorsthat appear in childhood are of embryonic origin. Malignantneoplasms (MN) remain one of the most serious diseases ofchildhood. At present, it is obvious that it is impossible totake measures aimed at reducing morbidity and mortalityfrom MN and to improve the quality of life of cancerpatients without proper accounting and registration of thispatients’ group. The structure of oncopathology in childrenof different age groups of Vinnitsia region is given.The purpose of the study is to provide medical andstatistical assessment of malignant neoplasms in children ofVinnitsia region and to highlight the experience of treatmentof a newborn with giant teratoblastoma of external-internallocalization and teratoma of internal localization.Results. The profile of malignant neoplasms in childrenof Vinnitsia region has been presented and the clinical caseof giant teratoblastoma of external-internal localizationand teratoma of internal localization has been described.Conclusions. The most informative diagnostic methodis computed tomography with contrast enhancement, whichallows you to clearly determine the topographic location ofthe tumor and its relationship to the surrounding anatomicalstructures, considering the complexity of the anatomicallocation of sacrococcygeal teratoblastoma (SCT). Earlysurgical treatment of SCT, namely removal of the tumorwith the coccyx, is the only correct and justified treatmenttactic.
PROBLEM ISSUES OF PREVENTIVE WORK OF PRIMARY CARE INSTITUTIONS
Authors: Domytrachuk I.S. , Melnychuk L.V.
Published: October 2021

Introduction. The article is devoted to the problematicissues of preventive work of primary care institutions.The purpose of the study: is to analyze the effectivenessof preventive areas of work of primary care physicians.Material and methods. The implementation of thevolume of preventive vaccinations for 2018-2020, theresults of preventive examinations of children has beenstudied. A survey of medical workers and parents of childrenon the effectiveness of preventive work was carried out.Results. Irregular delivery of vaccines (from 35% to78% for all groups of immunological drugs) significantlyaffected the implementation of preventive vaccinations,which decreased compared to previous years. Theuncertainty of the health workers themselves about thesafety of vaccines, which is the case with family doctors(65.33 ± 2.92 %) and their nurses (51.24 ± 2.53 %), remainsproblematic. Examples of successful prevention work arethe increase in the number of children under 6 monthsof age who were exclusively breastfed (74.3 %) and thecommitment of parents to breastfeeding (83.5 - 85.5 %).Conclusions. The problematic issues of preventivework are lack of time, lack of vaccines, low prestige ofpreventive work and lack of material incentives. From30.6% of parents at pediatricians to 41.7% of parentsat family doctors are dissatisfied with the amount ofinformation received from medical workers.
Modern possibilities of forensic medical evaluation and differentiation of acute intoxications
Authors: Dunaiev Oleksandr , Kozlov Serhii , Oliynyk Igor , Bratenko Mykhailo
Published: October 2021

This article analyzes modern scientific sources on the problems of detection of toxic substances in the human body, considers the existing methods of toxicological examination used in practical forensic medicine to establish and differentiate acute intoxications with various chemical compounds. Despite the presence of a large number of methods of toxicological analysis, forensic diagnosis of poisoning is often complicated due to lack of data on the circumstances of the event, clinical data of poisoning, pathognomonic signs of poisoning, the difficulty of interpreting the results.

Conclusions. When interpreting the results of a toxicological study should always take into account the circumstances of the case and factors that may have influenced the change in the concentration of toxic substances. There is a need to develop and implement in practice forensic toxicology laboratories fundamentally new diagnostic approaches for the detection of toxic substances and the differentiation of types of poisoning.
Forensic differential diagnosis of ethanol and carbon monoxide poisoning by diffused tomography of polarization images of polycrystalline blood films
Authors: Ivaskevych Igor , Vanchulyak Oleh , Olar Oleksandr
Published: October 2021

This work is devoted to the study of the possibilities of applying the method of differential polarimetric microscopy with algorithmic reproduction of fluctuations of linear and circular birefringence of polycrystalline component of human blood films in forensic practice for differential diagnosis of alcohol and carbon monoxide poisoning.

Aim of the work. Development of a set of forensic objective criteria for the possibility of differential diagnosis of ethanol and CO poisoning by diffuse tomography of polarization images of polycrystalline films of human blood.

Materials and methods. The object of the study were polycrystalline blood films obtained from 98 corpses of both sexes aged 18 to 70 years. The cause of death was acute ethanol poisoning (n=36), acute CO poisoning (n=32) and biological tissue samples from those who died of coronary heart disease (n=30) were used for control. The studies were performed by diffuse tomography of linear and circular birefringence of fluctuations of the polycrystalline structure of human blood films.

Results. The results of statistical analysis of data of algorithmic polarization reproduction of coordinate distributions of linear birefringence of fluctuation of albumin-globulin polycrystalline networks and circular birefringence of optically active chiral molecules, revealed a high level (statistical reliability p1; p2; p1;2<0,05) of diagnostic efficiency of forensic digital differentiation of blood films samples from people died of coronary heart disease, ethanol and carbon monoxide poisoning based on the calculation of a set of statistical moments of the 1-4-th orders.

Conclusions. The possibility of statistically significant (p1; p2<0,05) differentiation of cases of ethanol and CO poisoning by diffuse tomography of linear and circular birefringence of fluctuations of the polycrystalline component of the blood films has been established. The operational characteristics of the diagnostic power of the method corresponding to the excellent (92 % and 97 %) level are determined.
Microbiota of semen samples with normozoospermia: analysis of real-time PCR data
Authors: Voroshilina ES , Zornikov DL , Ivanov AV , Pochernikov DG , Panacheva EA
Published: October 2021

The analysis of semen microbiota is difficult due to the lack of established criteria for interpretation of microbiological tests. The aim of the study was to determine the stable clusters of semen microbiota analyzed by real-time PCR in samples with normozoospermia. Semen samples of 227 men with normal spermiograms were included in the study. The quantity of total bacterial DNA and at least one group of microorganisms was more than 103 GE/ml in 107 (41.7%) samples. Four stable microbiota clusters with the prevalence of a specific microorganism group were distinguished in these samples: obligate anaerobes (OA) cluster (proportion in the centroid — 81.1%); Lactobacillus spp. cluster (proportion in the centroid — 64.3%); gram-positive facultative anaerobes (GPFA) cluster (proportion in the centroid — 92.5%); Enterobacteriaceae/Enterococcoccus (EE) cluster (proportion in the centroid — 80.8%). The clusters were ranked by frequency of occurrence: OA cluster was the most prevalent (43 (40.2%) of 107), second-most frequent were GPFA-cluster (27 (25.2%)) and Lactobacillus-cluster (22 (20.6%)). EE-dominated cluster was found in 15 (14.0%) cases.
POSSIBILITIES OF CYBER-PHYSICAL APPROACH TO STUDYING FREQUENCY PROPERTIES OF CLOSED SYSTEM WITH INCOMPLETE INFORMATION ABOUT CONTROL OBJECT MODEL
Authors: Krushel Elena Georgievna , Potafeeva Ekaterina Sergeevna , Ogar Tatyana  Petrovna , Stepanchenko Ilya Viktorovich , Kharitonov Ivan Mikhailovich
Published: October 2021

The article considers a method of reducing the time spent on the experimental study of the frequency properties of an object with an unknown mathematical model by using the cyber-physical approach to the automation of the experiment. Nonparametric estimates of unknown frequency characteristics of an object are received from experimental data on the reaction of the object's output to the input harmonic signal in the form of a mixture of sinusoidal signals of different frequencies. To divide the output signal into components corresponding to each frequency, a computer technology is used that implements an optimization procedure for finding the values of both real and imaginary frequency characteristics, according to the frequencies represented in the harmonic input signal. The method is also suitable for accelerated evaluation of the frequency characteristics of an object with an unknown delay. There are considered the aspects of frequency properties estimation in the problem of closed system stability analysis, which is supposed to control an object with incomplete information about its model using a series-connected proportional-integral controller. The results of quick estimating the frequency characteristics of the object are used to identify the parameters of its transfer function. To solve the parameterization problem, there are used automation tools for calculating the transfer function according to data on the points of frequency characteristics implemented as part of the open-access computer mathematics system Scilab. There is given an example illustrating the possibilities of developing a control system using

a reduced-order object model, as one of the applications of the results of parametric identification of the transfer function
ALGORITHM AND METHODS OF RANKING GROUP OF BITMAP IMAGES
Authors: Afonin Viktor , Savkina Anastasia Vasilevna , Nikulin Vladimir
Published: October 2021

The article presents an algorithm and a methodology of ranking a group of raster images by using the criterion of their expected quality. Ranking refers to the evaluation of a sample of bitmap images in a descending order of their quality, the image quality assessment being performed on the basis of a number of statistical parameters, such as coefficients of variation, determination, rank correlation index, as well as errors (absolute maximum error, average error, average quadratic error). The differences between the images are based on converting a full-color RGB image into HSV, Lab, NTSC, XYZ, YCbCr color models, which are represented as one-dimensional pixel ma-trices. The colour model RGB is taken as a reference. In relation to it, the proposed statistical char-acteristics of other color models are compared, any object of each color model being compared with the base model - an RGB image. Based on this comparison, all images of a given group are analyzed independently of each other. Image quality assessment is performed in a module that can be used to cycle through multiple images and is represented in numerical form as a real number. One of the module blocks calculates the statistical parameters between each color model and the base RGB model. After receiving the values of the quality scores they are ranked according to their values. As a result, an image with a higher or lower scene quality can be determined. Images with blocking artifacts, noisy images of the salt & pepper type, and images with strobe effects artifacts were considered as test images.
FROM INHABITANT TO ATTENDEE IN THE EVENTFUL CITY OF CLUJ-NAPOCA: AN EXPLORATORY AND DESCRIPTIVE APPROACH
Authors: BOTA Marius , LAMUREAN Lavinia
Published: October 2021

Worldwide the events industry is a developing one. It can be pointed out that it is directly connected to the development of communities in each destination. Events are well-known as an ageless concept, as being a part and of high importance in our footprint as humans. Cluj-Napoca, known as events destination, became a qualitative source of entertainment with options ranging from cultural festivals, gastronomic fairs, business meetings, self-development seminars, community gatherings to sports and athletic demonstrations. It displays a top-class portfolio of events, a range of all sizes and content, from the local traditional fairs, emblematic festivals such as TIFF Festival and Electric Castle, to a major entertainment source that is Untold Festival. Moreover, every event has its own authenticity and content, making it almost impossible for its participants to not find one in Cluj-Napoca with options ranging from all kinds of events. The purpose of our study was to identify and analyze the motivating and inhibiting factors for the residents, in attending events from Cluj-Napoca market, as well as the development of a profile of them as consumers. A secondary data analysis was used to explore the field of events. In 2020 for two months, a survey was conducted for data collection. A short questionnaire was implemented through a correspondence interview. The retained sample was 258 residents from Cluj-Napoca. Only a part of the collected data was used in the present study.
JEL classification: L83, M31
A Content Analysis of Public Policy Design and Implementation in Slovenia: Weighing Strategic and Normative Factors
Authors: KOTNIK Žiga , STANIMIROVIĆ Dalibor
Published: October 2021

"Policy processes are complex systems and require an in-depth and comprehensive analysis. Especially, factors that affect public policy design and implementation, as two important stages of the public policy cycle, have not been sufficiently explored. The aim of the paper is to analyze the relationship between two critical factors that influence the design and implementation of public policies in the case of Slovenia, namely strategic factors and normative factors, and offer a basis for comparison with similar countries.
Based on twenty-two structured interviews with prominent public policy experts in Slovenia and content analysis of the responses, the findings reveal that, although strategic factors are identified by the interviewees as the most critical, the role of normative factors is also important and should not be underestimated. For various reasons, in practice, normative factors often turn out to be crucial."
Notas sobre o direito à memória no ambiente digital e sua relação com os arquivos
Authors: Cabral Jacqueline Ribeiro , Pereira Igor Muniz
Published: October 2021

Aborda a relação entre o direito à memória e os documentos de arquivo. Recorre à psicologia para conceituar, em um primeiro momento, a memória como um fenômeno individual. Posteriormente, destaca-se a dimensão coletiva que assume ao ser discutida no campo da arquivologia. Apresenta situações nas quais os arquivos são utilizados com a finalidade de permitir o exercício do direito à memória, citando como exemplo o contexto da redemocratização após as ditaduras militares brasileira e argentina. Questiona as possibilidades de construção da memória no ambiente digital. Com o objetivo de investigar iniciativas que tratam dessa temática, conceitua o modelo OAIS, enfatizando as plataformas arquivísticas de descrição, difusão e acesso. É apresentado um estudo de caso de dois sites que se utilizam destas para construção da memória: Mercosur - Guía de Archivos Y Fondos Documentales; e Lesser Slave Lake IRC Treaty Aboriginal Rights. Por fim, reflete sobre a atuação de arquivistas e sua capacidade para lidar com os documentos diante da realidade digital.
O contexto da política de indexação em arquivo permanente
Authors: Nakagawa Jacqueline , Fujita Mariângela
Published: October 2021

A política de indexação é constituída por diretrizes para tomada de decisão pelo profissional indexador que visam a padronização e sistematização do processo de representação temática da informação de documentos, porém, esse tema é pouco explorado no cenário dos arquivos permanentes. Com o objetivo de identificar e caracterizar a política de indexação em arquivos permanentes foi realizado estudo de observação participante no Centro de Documentação e Memória da Unesp (CEDEM) com aplicação de três técnicas de coleta de dados: questionário adaptado das bibliotecas para os arquivos permanentes, entrevista e a técnica introspectiva do protocolo verbal. Os resultados obtidos das coletas de dados revelam que a falta de manual ou roteiro de procedimentos de uma política de indexação, podem acarretar em falta de padrões que facilitem a atividade do profissional atuante em um arquivo permanente, por mais que os documentos possuam especificidades diferentes de uma biblioteca. Conclui-se que existe carência de estudos em torno da política de indexação em concomitância com os arquivos permanentes, e dessa forma, dificulta a atividade do profissional de indexação/descrição temática, que no caso do CEDEM, seria imprescindível para garantir melhor resultado na recuperação da informação, devido ao baixo número de pessoas dedicadas à essa atividade.
Silencios forzados
Authors: Bantar Patricia Elizabeth
Published: October 2021

El presente trabajo propone al lector un recorrido por diferentes músicas creadas en los campos de concentración y/o exterminio nazi. Invita a la escucha atenta y situada de las producciones artísticas a fin de apelar en el presente, tanto a la memoria como a la reflexión susceptible de compromiso.
Formación en Escritura Creativa para un desenvolvimiento como crítico, narrador y educador. Entrevista a Ángel Misari
Authors: Delgado Del Aguila Jesús Miguel
Published: October 2021

En este trabajo, se realizó una entrevista al docente Ángel Misari, quien explica cómo aplica sus conocimientos adquiridos en la Maestría en Escritura Creativa que hizo en la Universidad Nacional Mayor de San Marcos. Su intervención es de utilidad, ya que profundizará en la transferencia oportuna de ese saber en tres ámbitos: en su función como crítico de la producción artística, en su interés ficcional en la parte creativa y en la educación con estudiantes. En suma, la experiencia que manifiesta revela su formación literaria, así como las influencias y los motivos que lo impulsaron a desenvolverse en esta carrera.
Desigualdad social en Argentina: trabajo y género
Authors: Jodurcha Carolina
Published: October 2021

La propuesta pedagógica presentada está orientada a estudiantes que cursan la materia Geografía en 5to. año del Bachillerato de Bellas Artes “Prof. Francisco A. De Santo”. A partir del abordaje de temas que involucran los procesos de desigualdad socioespacial y el reconocimiento de la importancia del trabajo y el empleo para la sociedad contemporánea, se busca situarlos/as en su propia experiencia social y del espacio, bajo marcos de interpretación y saberes geográficos actualizados y diversos. De este modo, se analizan, desde la perspectiva de género, estudios de caso, permitiendo el ejercicio de la crítica y la reflexión sobre la sociedad en la que viven.
Developing the socially responsible investment practice in the context of national economic security
Authors: KHUTOROVA Natal'ya A. , KHUTOROV Andrei O.
Published: October 2021

Subject. The article addresses the issue of sustainable and socially responsible investment in the context of economic security.
Objectives. The aim is to prove a hypothesis that the development of the practice of socially responsible investment can be considered as one of factors in strengthening the economic security of the State.
Methods. We employ general scientific research methods.
Results. We analyze the main indicators of the development of the socially responsible investment market in the world and in Russia, systematize key participants of the market, their functions and role in ensuring the economic security of the State and company. We offer a number of areas for the development of socially responsible investment, which will contribute to strengthening the economic security, including raising awareness of the financial community about sustainable financing and formation of new behavioral patterns of investment portfolios; incorporating ESG instruments in the monetary policy of the Bank of Russia; developing incentive mechanisms for companies that actively use ESG principles in their business models, formulating international initiatives and standards for ESG financing in the EAEU.
Conclusions. In the current financial market conditions and active transformation of business models, the influence of ESG factors will increase. It will stimulate the development of the market for socially responsible investment and contribute to economic security strengthening. The proposed measures can be integrated into the process of formulating a long-term strategy of socio-economic development of the Russian Federation.
Polymodeling of time series structures, neighborhood of residuals distribution, wavelet transformation for meso-dynamics assessment
Authors: SEMENYCHEV Valerii K. , KHMELEVA Galina A. , KOROBETSKAYA Anastasiya A.
Published: October 2021

Subject. The article provides the results of meso-dynamics analysis of main twelve industries, based on monthly data for 82 Russian regions, from January 2005 till December 2020.
Objectives. The purpose of the study is to address the problem of balanced and stable spatial development of Russia’s regions and Russia, which requires modeling of adequate tools and forecasting nonlinear mesodynamics.
Methods. The study follows the econophysics methodology.
Results. We consider additive and multiplicative interactions of regular time series components between each other and the residuals, thus expanding the scope of tools application for the variety of considered industries and their models. Using the common and new trend models, we analyze structural changes, introduce the topological measure of proximity to the neighborhood of residuals with heavy-tailed distribution, which is estimated by median values of trends and cycles for regular components. The traditional time series decomposition (by trend, cycle, seasonality, and residual) is supplemented by our unique complex of wavelet transformations, which forms the models of cycles, using auto regression. We obtained representative and time-synchronized analytical estimates of regular components of industries’ dynamics for meso- and macro-indicators of the Russian economy that have higher accuracy than the known results for the accuracy of modeling and forecasting.
Conclusions. The offered methodology and tools enable a more adequate analysis of non-linear dynamics of regions’ middle-term development. They help shift to growth point identification, create the atlas of economic industrial cycles, analyze stages of bifurcations and scenario predictive planning.
Sandwich EVAR is Salvageable Technique in Juxtarenal AAA
Authors:   Khon Kaen University, Prasertcharoensuk Supatcha
Published: October 2021

The most common technical concern in Endovascular Aneurysm Repair (EVAR) is the proximal landing zone of stent. Sandwich technique is the effective procedure to preserve internal iliac blood flow. This case report describes using this procedure for successful EVAR in patient with juxtarenal abdominal aortic aneurysm.
Mathematical Modeling of Blood Flow to Evaluate the Hemodynamic Significance of Peripheral Vascular Lesions
Authors:   Memorial Care Heart And Vascular Institute, Shavelle David
Published: October 2021

Background: Evaluating the severity of peripheral artery lesions is challenging. Image-based blood flow modeling from peripheral Computed Tomographic Angiography (pCTA) may provide a non-invasive method to determine the hemodynamic significance of lesions. This pilot study evaluates the performance of pCTA-based blood flow modeling in diagnosing functionally significant peripheral lesions in comparison with Digital Subtraction Angiography (DSA). Methods: Ten patients undergoing DSA and pCTA were included. The peripheral arteries were divided into 8 segments per extremity and stenosis severity was graded by visual estimation from DSA. Each segment was graded 0 to IV (normal, mildly-stenotic, moderately-stenotic, severely-stenotic, occluded) or non-evaluable. Independent from DSA review, a Resting Pressure Drop (RPD) and an Exercise Pressure Drop (ExPD) for each segment was calculated from pCTA-based blood flow modeling. A functionally significant (FS) lesion was defined as grade III or IV by DSA and RPD > 5 mmHg from pCTA-based modeling. Analysis was repeated with an ExPD > 20 mmHg. Sensitivity, specificity and accuracy were calculated for RPD > 5 mmHg and ExPD > 20 mmHg using DSA as the standard. Results: Mean age was 52±16 years, 4 patients were male, 8 patients presented with critical limb ischemia, mean ankle brachial index was 0.60±0.29, and 66 arterial segments were available for both assessment methods. Twenty-two segments had FS lesions by DSA. Using an RPD > 5 mmHg, sensitivity was 80%, specificity was 85% and accuracy was 79%. Using an ExPD > 20 mmHg, sensitivity was 84%, specificity was 89% and accuracy was 88%. Conclusion: Use of a resting pressure drop > 5 mmHg and an exercise pressure drop > 20 mmHg, measured by blood flow modeling from CT angiography, can accurately identify functionally significant stenosis in patients with peripheral vascular disease. This information motivates the need for a larger-scale prospective imaging trial to further validate this novel non-invasive approach.