bluuebunny/crossref_metadata_2025 huggingface dataset:
Desfazimento eficiente de equipamentos eletroeletrônicos no IFES campus Serra - Espírito Santo
Authors: Almeida Marcelo Franco de , Campos Adriana Fiorotti
Published: November 2024

A pesquisa aborda o aperfeiçoamento do processo de desfazimento de bens patrimoniais no Instituto Federal do Espírito Santo (IFES), com foco no descarte de resíduos eletroeletrônicos. O objetivo geral é analisar esse procedimento e propor melhorias para torná-lo mais eficiente. Com relação aos objetivos específicos, busca-se avaliar o processo atual, identificar gargalos, classificar os bens inservíveis e sugerir soluções para otimizar a gestão patrimonial. A metodologia adotada é qualitativa, com uso de mapeamento de processos, observação participante, pesquisa documental e pesquisa bibliográfica. O mapeamento seguiu orientações do Manual de Procedimentos Patrimoniais do Centro Federal de Educação Tecnológica do Espírito Santo (CEFETES), permitindo visualizar etapas e responsabilidades do processo de desfazimento. Já a coleta de dados incluiu documentos institucionais, legislações e inventário. As principais conclusões indicam a necessidade de unificar procedimentos e melhorar a comunicação interna, que se mostrou ineficiente com o uso exclusivo de e-mails institucionais. Recomenda-se a adoção de aplicativos de mensagens instantâneas para agilizar o processo. Também se sugere uma comissão de avaliação mais engajada, com participação ativa da Coordenadoria de Tecnologia da Informação. As melhorias propostas têm o potencial de beneficiar outras instituições públicas, fortalecendo a eficiência organizacional e enriquecendo a discussão sobre a gestão de resíduos eletroeletrônicos.
Eugenia institucional: estudo dos Annaes de Eugenia
Authors: Costa Neto Antonio Gomes da
Published: November 2024

O presente trabalho analisa os Annaes de Eugenía, publicado pela Sociedade Eugênica de São Paulo. Ao se institucionalizar, a Eugenia é definida como um projeto científico, político e social, responsável por materializar e consolidar a Ciência Eugênica. Trata-se de movimento articulado, organizado e estruturado, com o intuito de implementar, de consolidar e de perpetuar suas propostas por meio das premissas identificadas no mito da pureza de sangue, no discurso colonialista e na sua operacionalização no racismo científico. Pressupostos religiosos, políticos e científicos transformaram o mito em crença e a Eugenia em Ciência; assim, o aperfeiçoamento humano converteu-se em uma verdade que se consolidou como corrente científica em escala global. Essa proposta foi desenvolvida com a intenção deliberada de constituir, de perdurar e de estabelecer a Ciência Eugênica. A Eugenia tem a finalidade de expandir, de reverberar, de materializar e de efetivar sobre a humanidade um projeto científico. É um mecanismo articulado de inculcação que visa estabelecer, fomentar, divulgar e difundir suas ideias nos diversos espaços sociais. O resultado são processos ideológicos que buscam consolidar a Eugenia na Ciência, na Política e na Sociedade.
Pharmaceutical Analysis and Evaluation of In-vitro Antibacterial Activity of Gomutra Ghana: A Concentrated and Solidified Form of Cow’s Urine
Authors: Raut Payal Ashok , Rathi Bharat Jagdish , Wanjari Anita Santoshrao , Meshram Supriya Mukunda
Published: November 2024

Introduction: Cow’s urine has been described as a highly effective animal-derived substance. Its therapeutic and pharmacological actions make it effective in the treatment of a variety of disorders. One of its notable properties is its antibacterial action, where the drug’s ability to target and inhibit the growth of bacteria. However, due to the pungent odour and taste of cow’s urine, it is difficult to consume in its natural form. Additionally, the collection of fresh cow’s urine can be challenging, especially in urban areas where access to cows may be limited. So, it is important to modify it into a dosage form, like Gomutra Ghana, which improves palatability and shelf life. Aim: To study the pharmaceutical development, quality control assessment, and in-vitro antibacterial activity evaluation of Gomutra Ghana. Materials and Methods: The pharmaceutical and analytical studies were carried out in Mahatma Gandhi Ayurved College Hospital and Research Centre and Dattatraya Ayurved Pharmacy, Salod (H), Wardha, Maharashtra, India. The in-vitro (antibacterial) study was carried out in JNMC, Sawangi (M), Wardha, Maharashtra, India, from April 2022 to August 2023. The in-vitro antibacterial study of cow’s urine and Gomutra Ghana was performed on five bacterial strains. Fresh cow’s urine was collected from a goshala (cowshed), and Gomutra Ghana was prepared in three batches by boiling the cow’s urine to a thicker consistency, then sun-drying it, followed by drying in an electric dryer. The final product was stored in a clean, sealed glass jars. Analytical parameters like pH, loss on drying at 105ºC, total ash, water-soluble ash, acid-insoluble ash, water-soluble extractives, alcohol-soluble extractives, and microbial contamination were studied. The in-vitro antibacterial activity was evaluated using the agar disc diffusion method at concentrations of 5 μL, 10 μL, and 15 μL, with results compared to those of a broad-spectrum and commonly used antibiotic, ciprofloxacin (5 μg). Statistical analysis was performed using Statistical Package for the Social Sciences (SPSS) version 27.0, employing Analysis of Variance (ANOVA) to compare three groups (Ciprofloxacin, cow’s urine, and Gomutra Ghana) at all three concentrations. A significance level was set with a p-value of <0.05 for the antibacterial study. Results: High-Performance Thin-Layer Chromatography (HPTLC) showed a peak from cow’s urine and Gomutra Ghana, with maximum heights of 500.1 and 450.4, which were nearly the same, so they may contain similar constituents. An extra peak was observed in Gomutra Ghana, suggesting the presence of additional compounds formed during its preparation. Gomutra Ghana extract showed the highest zone of inhibition against Escherichia coli. Conclusion: Gomutra Ghana showed antibacterial properties, which warrant further exploration in humans for safety and efficacy in humans.
Congenital Dermoid Fistula of the Anterior Chest Region: A Case Report
Authors: Khaladkar Sanjay M , Samudrala Sujith Kumar
Published: November 2024

Congenital Dermoid Fistula of the Anterior Chest Region (CDFACR) is a subcutaneous fistula that ends caudally in the subcutaneous tissue close to the sternoclavicular joint, originating from the skin at the anterior border of the sternocleidomastoid. The fistulous track is lined by keratinised stratified squamous epithelium with hair follicles, sebaceous glands and sweat glands. It presents clinically as a cutaneous pit, sinus, or infected mass. It is rare and can be complicated by recurrent infection and abscess formation. Before surgery, imaging the complete extent of the sinus is essential to prevent recurrence. Authors hereby, report a case of a 20-year-old male presenting with discharge from the anterior chest wall. On radiological and histopathological examination, it was diagnosed as a congenital dermoid fistula. In the present report, authors present a case of CDFACR confirmed through comprehensive evaluation, including sonography, Computed Tomography (CT) sinography, Magnetic Resonance Imaging (MRI) and histopathology. The present case also represents the first documented instance of CDFACR from India, highlighting the importance of multimodal imaging in the diagnosis and management of this rare congenital anomaly.
Gen-Z Entrepreneurial Intentions: Exploring the Impact of Risk, Achievement Needs, and Social Media Engagement
Authors: Aryoko Yudhistira Pradhipta , Anggara Ali Akbar , Fauziridwan Meydy
Published: November 2024

This research explores the relationship between risk-taking propensity, need for achievement, social media engagement, attitudes toward entrepreneurship, and entrepreneurial intention among Gen-Z entrepreneurs in Banyumas Purwokerto. Gen-Z, known for their digital fluency and innovative outlook, presents unique insights into entrepreneurial intention, making them a compelling focus for this study. Using Structural Equation Modeling (SEM) with the Partial Least Square (PLS) approach, selected for its ability to handle complex models with mediating effects, the study surveyed 150 participants. Findings reveal that risk-taking propensity, need for achievement, and social media engagement significantly and positively influence entrepreneurial intention. Additionally, attitudes toward entrepreneurship mediate these effects, highlighting the role of mindset in translating individual characteristics into entrepreneurial ambitions. Practical implications suggest that educators, policymakers, and business mentors can enhance entrepreneurial intention by fostering supportive environments that nurture these traits and positively shape attitudes toward entrepreneurship among Gen-Z.
Physico-Chemical Analysis of Textile Effluents from Bagru, Jaipur (Rajasthan, India): Implications for Environmental Impact and Treatment Needs
Authors: Singh Malvika , Bhadauria Seema , Meena Sumit
Published: November 2024

The textile industry is one of the largest water polluters worldwide. The coloured and bad odour effluent discharged from such industries pollutes not only the water bodies but also affects groundwater quality. In the present study, thirty-five water samples were collected from different dyeing units of the Bagru textile area (Rajasthan, India) famous for using natural dyes for textile processing. The physico-chemical analysis of these water samples shows that all parameters exceeded the permitted range recommended by the Central Pollution Control Board (CPCB) and World Health Organization (WHO). The analysis revealed the use of synthetic dyes in Bagru's textile industry for dyeing and printing. Based on the estimated characteristics, these textile effluents must be properly treated before releasing into the environment as the discharge of untreated effluents into local water bodies leads to significant water pollution, adversely affecting aquatic ecosystems and biodiversity. Additionally, contaminants can permeate the soil, compromising agricultural productivity and food safety. The air quality is also compromised due to the release of volatile organic compounds (VOCs) during the dyeing process, posing respiratory risks to nearby communities. This research underscores the urgent need for improved waste management practices and regulatory measures to mitigate the adverse environmental effects associated with synthetic dyes in Bagru's textile industry.
Impact of Land Use and Land Cover Changes on Soil Physico-Chemical Properties in Southern Tigray, Northern Ethiopia
Authors: Gidey Abadi , Tassew Tuemay
Published: November 2024

Soil quality declines due to the conversion of natural vegetation into farmland and grazing areas. The response of soil properties to land use and land cover changes (LULC) exhibits both spatial and temporal variations. This study aimed to assess the effects of LULC changes on the physico-chemical properties of soil in the Wojic watershed. Soil samples were collected from natural forests, bushland, shrubland, and cultivated lands across three landforms of the watershed (upper, middle, and lower) to evaluate the physical and chemical properties of the soil associated with different LULC types. The LULC categories were compared using mean values and critical thresholds for selected physicochemical soil properties. Soil analysis was conducted using R software, employing one-way analysis of variance (ANOVA). A normality test was performed before the post hoc analysis, and Tukey’s honest significance difference (HSD) test was utilized for mean separation among the LULC types. Additionally, a normalized difference vegetation index (NDVI) was calculated for the years 1997 and 2017. A simple linear regression model was developed to estimate soil physico-chemical properties over the past 20 years, using laboratory soil parameters and the NDVI for 2017. The pH values showed a slight decrease in cultivated land (from 5.7 to 5.4), bushland (from 7 to 6.6), and shrubland (from 6.5 to 6.2) over the study period. The analysis indicated a declining trend in physico-chemical properties, attributed to changes in vegetation cover and management practices. Consequently, the government needs to enforce policies and regulations that promote effective land resource management and utilization, with particular emphasis on the proper management and conservation of forests, bushlands, and shrublands, as well as measures to prevent increased land resettlement.
Exploring the Role of Artificial Intelligence in Revolutionizing Microbial Diagnostics
Authors: Elshafei Ali Mohamed
Published: November 2024

Identifying the microorganisms responsible for illnesses and infections is crucial for accurate diagnosis, which is an essential aspect of providing medical care. Artificial intelligence (AI) systems can enhance drug discovery, epidemiological monitoring, prediction of antibiotic resistance, and disease management in the field of microbiological diagnosis. Artificial intelligence (AI) is a branch of science and technology that uses computers to simulate human intelligence. AI has recently shown tremendous promise as a powerful computational tool for the detection and management of bacterial infections. These machines can imitate human thought processes and cognitive capacities. Today, pathogen identification and Antimicrobial Susceptibility Testing (AST) in clinical laboratories often rely on culturing and isolating pathogens. With the rapid advancement of technology, Artificial Intelligence (AI) has become a vital tool for bacterial AST, providing numerous fast and efficient methods for testing drug susceptibility. AI systems offer enhanced diagnostic methods and early detection of antibiotic resistance. Moreover, they can rapidly and accurately identify diseases, including those that are novel or drug-resistant. In addition, AI can be applied to identify cells infected with malaria, detect drug resistance in pathogens like tuberculosis (TB) and HIV, understand and tackle antimicrobial resistance (AMR), and predict outbreaks. The primary goals of applying AI to bacterial diagnosis are the rapid and precise identification of pathogens and the prediction of drug resistance.
Current Models of Innovation and Market Strategies in Pharmaceutical Development: A Comprehensive Review
Authors: Gad Aliaa Gad Mohamed , Osarhiemen Itohanosa Omolara , Idama Vivian
Published: November 2024

This paper examines innovative models and market strategies in the pharmaceutical industry, highlighting how these innovations shape drug development, market dynamics, and public health outcomes. Pharmaceutical innovation spans product enhancements, process efficiencies, and organizational and marketing transformations, all aimed at improving patient outcomes and healthcare access. The methodology explored comprehensive literature review, focusing on recent developments in pharmaceutical innovation, drug marketing practices, and regulatory frameworks. Primary sources include scholarly articles from Google Scholar, ResearchGate, Scopus, and Web of Science, as well as industry reports and case studies from leading pharmaceutical firms. Key strategies explored include product and process innovations that make medications more effective and accessible, as well as open innovation models, which promote collaboration and cost-sharing in research. The review underscores the ethical and regulatory complexities of the industry, from patient-centered marketing to the rise of biosimilars. Future directions in pharmaceutical innovation, such as artificial intelligence and precision medicine, are presented as transformative tools for advancing personalized healthcare. These advancements reflect the sector's ongoing response to regulatory demands, economic pressures, and global health challenges, positioning the pharmaceutical industry as a crucial driver of public health and economic sustainability.
Biochemical Studies of Averrhoa carambola Ethanol Leaf and Fruit Extracts on Alloxan-induced Diabetic Rats
Authors: Onyinyechi Uju Philippa , Adamma Emejulu Angela , Ifeyinwa Ukairo Doris , Kelechi Ekeke Light
Published: November 2024

The use of herbal medicines has always been an option to treat diseases such as diabetes cancer and other ailments. This study aimed to evaluate the effect of Averrhoa carambola leaf and its fruit ethanol extracts on biochemical parameters and histopathology features. Forty five albino rats were assigned into 9 groups of 5 rats each. Except for the normal control group, others were induced to be diabetic by a single intraperitoneal injection of alloxan. Group 1 (normal control) and Group 2 (diabetic untreated) received water. Group 3 received 2.5mg/kg glibenclamide, Groups 4-9 received graded doses (250mg/kg, 500mg/kg and 750mg/kg) of leaf and fruit extracts of Averrhoa carambola. Treatment lasted 14days. At the end of the treatment, blood samples and organ (pancreas) were collected from the animals for biochemical and histopathological evaluation. Treatment of alloxan-induced diabetic rats significantly (p<0.05) reduced the glucose concentration across all treated groups. Following induction of diabetic mellitus, the serum activities of liver enzymes (Alanine amino transferase, Aspartate aminotransferase and Alkaline phosphatase), low-density lipoprotein cholesterol (LDL-C) and triglyceride were significantly (p<0.05) elevated in diabetic untreated group with corresponding reduction in serum protein, albumin and high-density lipoprotein cholesterol (HDL-C) compared to the normal control and treated groups. However, the fruit extracts exhibited a high increase in urea and creatinine levels especially at dose of 750mg/kg body weight when compared with the leaf though not significantly higher than the diabetic untreated group. From histopathology studies, the groups treated with the leaf extract of Averrhoa carambola showed greater structural improvement and an increase in pancreatic islet cells. Therefore this study showed that although ethanol extracts of Averrhoa carambola leaf and fruit have antidiabetic properties, the leaf extract possesses more antidiabetic effect.
Comparative Analysis of Nitrogen Use Efficiency in Boro Rice under Long-term Inorganic and Organic Fertilization Practices
Authors: Tabassum Thashin , Afrose Rashma , Kader Md. Abdul
Published: November 2024

An experiment was conducted during Boro rice in the permanent experimental field of the Department of Soil Science, Bangladesh Agricultural University (BAU), Mymensingh to investigae the long term outcome of manure and fertilizers on the yield and Nitrogen Use Efficiency (NUE) of BRRI dhan29 in floodplain (Subtropical) soil (Aeric Haplaquepts). The experiment was designed in a randomized complete block design with three replications. There were ten treatment combinations viz, control; Nitrogen (N); (Nitrogen Phosphorus) NP; Nitrogen Potassium (NK); Nitrogen Phosphorus Potassium (NPK); Nitrogen Zinc (NZn); Nitrogen Sulphur (NS); Nitrogen Sulphur Zinc (NSZn), Nitrogen Phosphorus Potassium Sulphur Zinc (NPKSZn) and NPK+FYM. The yield contributing characters and yield of BRRI dhan29 significantly increased due to different treatments. Grain and straw yields were highly influenced by the application of nutrients in various combinations. The longest panicle length (25.3 cm), the highest 1000 grain weight (22.7 g), the maximum grain yield (6.29 t ha-1), the highest nitrogen uptake in grain (70.4 kg ha-1) were found for the NPKSZn treatment. Grain yield increased by 24.8%, 85.8%, 40.7%, 68.9%, 29.2%, 33.2%, 107.1%, 28.9% and 78.9% due to N, NP, NK, NPK, NS, NSZn, NPKSZn, NZn and NPK+FYM treatments respectively and the corresponding straw yields attainment by 49.6%, 51.1%, 82.0%, 95.3%, 37.8%, 34.4%, 82.7%, 41.8% and 90.2%. The maximum value of apparent nitrogen use efficiency was obtained with NPKSZn (54.06%) treatment which evidently suggested its resultness for the long term fertilized soil.
Barriers and Strategies for Rotavirus and Cholera Vaccine Uptake: A Systematic Review of Community-based Interventions in Bangladesh, India, and Pakistan
Authors: ADINDU Kelechi Nelson , ENEMUO Nkechi Rita , OYEDEMI Daniel , NWAFOR Bafford , ONYEJELAM Frank Uche , JUDE Nnorom Obioma , NWABUEZE Ifunanya , OJOMO Philip , ONUOMA Ehioma Peter
Published: November 2024

Background: Diarrhea is the second leading cause of death in children and poses a major threat to public health. It is mainly caused by pathogenic organisms of viral, bacterial, or fungal origin, two of which has been preventable via vaccination and has been identified as rotavirus and cholera. In 2020, India, Pakistan, and Bangladesh were among the top 10 South Asian countries with the highest mortality rates from childhood diarrhea. India and Pakistan are further listed by the WHO among the top five countries with the highest recorded mortality among children under five years old. Bangladesh has experienced the highest number of cholera epidemics. Vaccination is recommended as a potent preventive approach against rotavirus and cholera induced diarrhea and is considered the most cost-effective prevention method. However, despite their proven effectiveness, other factors appear to affect the impact of vaccination strategies in these countries. Therefore, this study aimed to explore these nonclinical factors. 
Methods: This study was conducted as a systematic review which involved the systematic search and selection of qualitative data from primary studies concerning the research topic which was developed using the SPIDER framework. The PRISMA tool was used to carry out this process, and the CASP was used to evaluate the methodological quality of each study. The combined data were then harmonized using meta-synthesis and analyzed thematically. 
Findings: Four themes emerged from the analysis of the study data: pre-vaccination strategy experience, post-vaccination strategy impact, opportunities for vaccination strategies, and threats to successful implementation of vaccination strategies. This formed the basis of the study discussion and expounded on the impact of vaccine strategies in the selected countries.
Conclusion: The results of this study showed that providing the participants with correct information, vaccine education, willingness to learn despite poor knowledge, and access to vaccination are important solutions to the factors that surround the uptake and coverage of cholera and rotavirus vaccines in Bangladesh, India, and Pakistan as critical influencers of the prevalence of childhood diarrhea induced by rotavirus and cholera pathogens, respectively.
Optimization of Nano-DAP Fertilization for Improvement in Growth and Yield of Finger Millet (Eleusine coracana (L.) Gaertn.)
Authors: Khati Vaishnavi , Kumar Ajay , Kishore Amit , Paliwal Arunima , Raj Pratiksha , Rawat Anchal , Bisht Aditya Raj , Kumar Pankaj
Published: November 2024

Aim: Optimization of nano-DAP fertilization for improvement in growth, yield and to maximize the production of finger millet.
Study Design: Randomized Block Design (RBD).
Place and Duration of Study: This investigation was conducted in Kharif 2021 and 2022, with variety VL-352 at the Research and Extension Centre, Gaja, College of Forestry, Ranichauri (Tehri Garhwal), Uttarakhand, India.
Methodology: This experiment comprised of ten treatments viz., T1- NK 100% (Control), T2- NPK 100%, T3- 75%P + 100%N + 100%K, T4- 50%P + 100%N + 100%K, T5- 75%P + 100%N + 100%K + Seed Treatment (ST) + Foliar Spray (FS) (2mL), T6- 75%P + 100%N + 100%K + ST + FS(4mL), T7- 50%P + 100%N + 100%K + ST + FS(2mL), T8- 50%P + 100%N + 100%K + ST + FS (4mL), T9- 50%P + 100%N + 100%K + ST + FS(2mL) + FS(2mL), T10- 50%P + 100%N + 100%K + ST + FS (4mL) + FS(4mL) and was laid out in RBD with three replications. Measurements and calculations of plant growth parameters, yield attributes, and economic considerations were made.
Result: The plant growth and yield attributing parameters were recorded significantly higher in the treatment T10- 50%P +100%N + 100%K + ST + FS (4mL) + FS(4mL) while significantly lower yield was recorded in T1- NK 100% (Control).
Conclusion: The use of 50% P through DAP and 100% NK along with seed treatment by nano DAP @5mL/kg seed as well as two foliar sprays of nano-DAP @4 mL/L of water, first at 30-35 days after germination and second at 45 days after seed germination gave significantly higher plant growth, seed yield and seed quality of finger millet.
Impact of Fertility Levels and Biofertilizers on Chickpea Yield, Soil Fertility and Economic Returns
Authors: Kumar Y S Satish , Nayak S Balaji , Prabhakar K , Kiranmayi M. Jyostna , Kumar K Arun , Raghavendra T , Jayalakshmi V.
Published: November 2024

A field experiment was conducted for two rabi seasons (2019-20 & 2020-21) at Regional Agricultural Research Station, Nandyala, Andhra Pradesh to study biofertilizers of PSB and inorganic fetilizers on growth, yield and quality Chickpea crop for Kurnool district of Andhra Pradesh. Afetr two years of the study, Significantly highest available soil Nitrogen (188 kg ha-1), Phosphorous (66.9 kg ha-1) and Potassium (484 kg ha-1) were recorded in treatment T8 (100% RDF + PSB in liquid form). Significantly highest chickpea yield of 2156 kg ha-1 was recorded with T8 (100% RDF + PSB (liquid form), the lowest yield was recorded with control (1839 kg ha-1). However, this treatment yielded results comparable to all treatments except the control during the two rabi seasons of 2019-20 and 2020-21. The economic evaluation of biofertilizers and chemical fertilizers application in chickpea crop revealed that maximum net returns (Rs 1,02,675) and higher B: C ratio (3.45) were obtained with application of 50% RDF plus PSB application. The present study was done to study to evaluate the influence of bio fertilizers on growth and yield of chickpea.
PCR Based Technique for Identification of Bile Salt Hydrolase Positive Lactobacilli
Authors: B.M Manjunatha , G.S Spoorthy , Vijaykumar B.
Published: November 2024

In the burgeoning landscape of probiotic research, the intricate interplay between the gut microbiota and host health has underscored the significance of specific enzymatic activities, notably bile salt hydrolase (BSH) produced by Lactobacilli. Harnessing the potential health benefits associated with BSH activity necessitates a meticulous identification strategy. In response, this study introduces a sophisticated PCR-based technique tailored for the rapid and precise discrimination of lactobacilli strains boasting BSH enzymatic prowess. This PCR-based approach offers a valuable tool for researchers and industry professionals involved in the selection and characterization of probiotic strains with bile salt hydrolase activity. Its speed, accuracy, and adaptability make it a promising method for large-scale screenings and applications in diverse fields, ranging from food science to the development of probiotic supplements aimed at enhancing human health through the modulation of bile acid metabolism. robiotic supplementation, where the modulation of bile acid metabolism holds promise for promoting human health and well-being.
Influence of Different Nitrogen Concentrations on Growth, Yield, and Yield Attributes of Hydroponically Grown Cherry Tomato
Authors: Chettri Pravachan , Thapa Umesh , Shil Sanjoy , Tamang Dupchen , Tamang Tshering
Published: November 2024

This scientific study aimed to determine the optimal nitrogen concentration within a hydroponic solution for the Rosa variety of cherry tomato plants cultivated in a controlled greenhouse environment. The study was conducted over a period of October 2019 to April 2021. Various treatments were administered, each with distinct nitrogen concentrations, to evaluate their effects on plant growth, yield, and yield-attributing characteristics. The results unequivocally demonstrated that the application of 8 mmol/L of nitrogen (T3) emerged as the most efficacious treatment for optimizing the growth, yield, and yield-attributing characteristics of the cherry tomato plants. These findings hold significant implications for refining nitrogen management practices in horticultural crop production, particularly for the Rosa variety of cherry tomatoes, within controlled greenhouse settings.
Pathogenesis of Pyometra: Treatment and Diagnosis
Authors: Kartik  , MN Vinayaka , MG Kanakaraja , Kumar Sunil
Published: November 2024

Pyometra refers to an acute or persistent suppurative inflammation of the uterine wall. A six-year-old Persian cat was admitted to Pet Hospital, with history of anorexia and chronic emaciation.  During abdominal examination, the uterus felt larger and firmer than usual. Then ultrasonography examination was done and it revealed anechoic multiple pus pockets. Blood analysis showed that the level of AST, ALT, urea, creatinine increased, and PCV and Hb% decreased. All the findings confirmed that cat had suffering from pyometra. After confirmation, it was decided to do ovariohysterectomy under general anaesthesia. The suture was removed after fourteen days. The cat had a complete recovery without any complication.
Assessment of Risk for Immune and Psychiatric Disorders Using qPCR-Based Monitoring of the nan Gene in Gut Microbiota: A Non-invasive Approach
Authors: Nagasaka Mitsuo , Fujii Tadashi , Kamano Toshiaki , Mihara Seiya , Funasaka Kohei , Ohno Eizaburo , Mogi Chie , Hirooka Yoshiki , Tochio Takumi
Published: November 2024

Aim: This study aimed to establish a non-invasive, rapid, and cost-effective method to assess the potential risk of immune and psychiatric disorders by quantifying nan gene levels in gut microbiota, specifically focusing on Ruminococcus gnavus and other Lachnospiraceae species associated with mucin degradation.
Methodology: We first designed a primer set targeting the consensus sequence of the nanA gene, which is highly conserved within nan gene clusters. To validate this primer set, we performed Next-Generation Sequencing (NGS) on the PCR-amplified fragments. To explore the association between nan levels and immune or psychiatric disorders, we conducted qPCR to quantify nan levels in the intestines, analyzing intestinal DNA from both allergy-induced mice with or without fructan treatment, and dogs with or without aggressive behavior. Additionally, to assess whether nan levels reflect the clinical status of immune disorders, fecal samples were collected from 45 patients with ulcerative colitis (UC) and analyzed for nan levels.
Results: NGS analysis of DNA fragments amplified from various intestinal samples using the nan primer set confirmed the presence of nanA sequences from R. gnavus and other members of the Lachnospiraceae family, including Blautia and Dorea species. The qPCR quantification of nan levels using this primer set revealed that allergy-induced mice treated with fructans, which are known to be associated with lower allergy scores compared to untreated mice, exhibited significantly reduced nan levels. Additionally, the nan levels of aggressive dogs were substantially higher than those of non-aggressive dogs. Notably, nan levels were also substantially elevated in patients with UC in comparison to the healthy control individuals.
Conclusion: qPCR-based measurement of nan levels in gut microbiota shows potential for selectively detecting pathogenic nan-harboring strains and may reflect the clinical status of immune and psychiatric disorders. This approach could provide a non-invasive, rapid, and cost-effective method for assessing the risk of these disorders.
No princípio, era a angústia
Authors: Cesar Jamile
Published: November 2024

Este ensaio busca explorar a distinção e a interconexão entre a ansiedade e a angústia, tendo como foco suas origens etimológicas, interpretações filosóficas e psicológicas. A partir da análise da obra Angst de Edvard Munch e das traduções de respectivo termo norueguês, busca-se argumentar que a angústia, mais do que a ansiedade, poderia ser o termo original usado para descrever certas emoções profundas e existenciais retratadas na arte e discutidas na filosofia. A discussão culmina na ideia de que, embora a ansiedade seja frequentemente vista como distinta da angústia, ambas compartilham raízes conceituais profundas e sua separação pode ser mais uma questão de terminologia do que de essência. Assim, o ensaio não apenas revisita a complexidade semântica dos termos, mas também propõe uma reflexão sobre como as palavras moldam e limitam nossa compreensão das emoções e das experiências humanas.
ANGÚSTIA NA POÉTICA DE POE E BAUDELAIRE
Authors: Dos Santos Raul Lima
Published: November 2024

No ensaio que se segue, proponho-me a fazer uma leitura da manifestação da angústia em duas obras: no conto “The Fall of the House of Usher”, de Edgar Allan Poe; e no poema “Os Sete Anciões”, de Charles Baudelaire. Como pressuposto teórico sigo o seminário dez de Jacques Lacan, que ocorreu nos anos de 1962-1963; bem como o texto de Sigmund Freud publicado em 1919, intitulado “Das  Unheimliche”. Através da leitura conjunta dessas obras observamos os mecanismos por onde a angústia se manifesta e, dentro de sua especificidade, como ela pode ser apreendida e narrada em um texto poético-literário.
Macabê-a-bá
Authors: Machado Nuno Figueiredo Souza Venâncio Lopes
Published: November 2024

O desejo do sujeito é instaurado após a extração do objeto a da realidade, sendo constituído pelo lugar vazio deixado por ele, que engendra a movimentação do sujeito na tentativa de reintroduzi-lo na linguagem. Dito isso, a escrita literária pode ser pensada como uma produção motivada por um desejo, na tentativa de explicar essa falta. Logo, neste artigo, trata-se de elaborar, a partir da obra A hora da estrela, da autoria de Clarice Lispector, as possíveis aproximações acerca do desejo e seu objeto, no viés da teoria psicanalítica, com a narrativa de um texto literário. Nesse intuito, será argumentado como o encontro com um vazio desloca as personagens e a autora a constituírem o texto, buscando situar esse objeto na linguagem. Através da aproximação entre psicanálise e literatura, percebe-se a extensão de comutatividade que o saber psicanalítico e as obras literárias possuem entre si, permitindo um aprofundamento acerca do objeto.
“ESCREVER ASSIM MESMO, APESAR DO DESESPERO. NÃO: COM O DESESPERO” — DIÁLOGOS POSSÍVEIS ENTRE ESCRITA, ANGÚSTIA E PSICANÁLISE.
Authors: Queiroz Amanda Rodrigues
Published: November 2024

RESUMO
O presente ensaio tem como objetivo evidenciar as estreitas interlocuções entre escrita, angústia e psicanálise. Para tanto, foi fundamental revisitar a obra de alguns autores da psicanálise e da literatura, a fim de ampliar as discussões acerca da função e dos possíveis efeitos da escrita sobre o sujeito que escreve atravessado pela angústia. O gosto pronunciado pelas palavras aproxima o psicanalista, aquele que escreve e lê em sua prática, da figura do escritor; ambos lidam com o real e ensaiam formas de dizer o indizível. Escrever constitui uma experiência de elaboração que é única para cada sujeito, que compõe e decompõe a linguagem à sua maneira, a partir de suas marcas, histórias e bagagens simbólicas. À vista dessa abordagem, tomando a angústia como uma referência chave neste trabalho, enfatiza-se a importância da escrita para a psicanálise que, desde os seus primórdios, serve-se da arte e dos textos literários.
NOTAS SOBRE O CONCEITO DE ANGÚSTIA EM JÓ
Authors: Roger Jayder
Published: November 2024

Esse ensaio busca elaborar sobre o drama subjetivo da angústia do personagem bíblico de Jó, onde se revela uma condição humana universal, refletindo a luta para simbolizar e compreender o sofrimento. A resposta de Deus ao sofrimento de Jó não esclarece o motivo do tormento, mas destaca a complexidade do mundo e a impossibilidade de uma compreensão total, mostrando que até o divino está envolvido na dinâmica do desejo e da falta.
Amor, Não Monogamia e a Angústia da falta
Authors: Almeida Natália Vitória Coelho de
Published: November 2024

O relacionamento romântico, historicamente valorizado, envolve uma busca por completude e idealização do outro. Há séculos, um filósofo antigo falou sobre o amor como a busca pela metade perdida. Muito tempo depois, um psicanalista francês o define como a sublimação do desejo. Mais recentemente, outros autores propõem pensá-lo como um acontecimento pela diferença. Em meio a essas reflexões, a não monogamia se estabelece como uma contra norma à monogamia compulsória e como uma oposição ao amor romântico. Afeto este que, marcado pela busca de completude, nos gera angústia diante da falta. Considerando-se que somos sujeitos viventes, em constante transformação, atravessados por tudo o que nos toca, propõe-se refletir, então, como lidar com esta falta que nos é constitutiva, fazendo do amor um meio e não um fim. Conclui-se que viver em busca de nos completar vai contra a natureza do vazio que nos move. Em última análise, o amor nos possibilita admitir a falta que constitui tanto a nós mesmos quanto o outro.
Não se Deixar Afetar é Sintoma de Quê?
Authors: Machado Ricardo Gusmão
Published: November 2024

O presente ensaio propõe uma reflexão sobre o medo de se entregar ao amor, interpretando-o como um mecanismo de defesa contra a angústia de perder a falta primordial, constitutiva do sujeito. Com base nas distinções entre afeto e sintoma na psicanálise freudiana e lacaniana, é proposta a hipótese de que, em alguns casos, a evitação dos afetos serve para que o sujeito preserve sua incompletude, essencial para sustentar o movimento contínuo do desejo. A análise sugere que essa resistência ao amor reflete a necessidade de manter a falta, garantindo, assim, a permanência do desejo.
Editorial
Authors: Machado Ricardo Gusmão
Published: November 2024

Editorial do terceiro número da Revista Nós.
Comparison of semiautomated tangential VMAT with 3DCRT for breast or chest wall and regional nodes
Authors: Byrne Mikel , Archibald‐Heeren Ben , Hu Yunfei , Fong Andrew , Chong Leena , Teh Amy
Published: August 2018

Radiotherapy to the breast after surgery sometimes requires adjoining nodes to be included in the treatment volume. In these cases, the traditional approach has been a complex 3‐Dimensional Conformal Radiotherapy (3DCRT) beam arrangement which can result in significant dose heterogeneity at the beam junctions. A Volumetric Modulated Arc Therapy (VMAT) beam arrangement has previously been proposed for breast cases, where the chest wall/breast is treated with a limited angle (partial arc) tangential VMAT technique (Virén et al. [2015] Radiat Oncol. 10:79). In our study, this approach is extended to breast and chest wall cases with adjoining nodes by adding a separate conventional VMAT arc field specifically limited to the superior nodes. This VMAT method was implemented using a semiautomated approach on 27 patients, and the resultant plan compared to a monoisocentric 3DCRT plan. Plan statistics, Dose‐Volume Histogram (DVH) analysis and Radiation Oncologist (RO) preference were assessed. When compared to the 3DCRT technique, the VMAT planning method was found to result in better target volume coverage, high doses to organs at risk (OAR) were reduced but greater OAR volumes received low doses. Having said that, the volume receiving low doses with this tangential VMAT technique was less than that of other VMAT planning methods described in the literature, and the integral dose was less than the 3DCRT method. The VMAT technique also resulted in more robust junction doses that the 3DCRT method. RO review found that the VMAT technique was preferred in 81% of cases. Specifically, the VMAT plans were preferred in all categories of patients except left chest wall cases where the intermammary nodes were also treated. The VMAT technique described here is a useful addition to the treatment options available for breast/chest wall and nodal patients.
Efficient Perovskite Light‐Emitting Diodes via Tuning Nanoplatelet Distribution and Crystallinity Orientation
Authors: Zou Yatao , Huang Qi , Yang Yingguo , Ban Muyang , Li Siying , Han Yujie , Wu Tian , Tan Yeshu , Gao Xingyu , Song Tao , Sun Baoquan
Published: August 2018

Quasi‐2D Ruddlesden–Popper (RP) perovskites with quantum‐size‐tuned nanoplatelet crystallites are particularly attractive for light‐emitting diode (LED) applications because of their excellent charge transport, bandgap tunability, and narrow emission peaks. Favorable energy cascade structure in 2D RP perovskites can funnel the photoexcitation from large‐bandgap nanoplatelets to the lowest bandgap ones, which promises efficient radiative recombination. However, how to rationally control the nanoplatelet distribution as well as the crystallization characteristics to ensure efficient energy transfer and charge transport in perovskite films is still challenging. Here, a simple path to facilely tune the nanoplatelet distribution as well as the crystal orientation via carefully controlling postannealing condition is provided. With optimizing the thermal annealing time, compact and flat perovskite films with high photoluminescence quantum yield are obtained. Based on the optimized perovskite films, green LED with a current efficiency of 43.7 cd A−1, corresponding to an external quantum efficiency of 13.9%, is achieved. This work provides a simple path to target highly efficient perovskite LED devices.
MnO2/PtNP Embedded Wet‐Spun Fiber Supercapacitors
Authors: Kim Ji Hwan , Lee Jae Myeong , Park Jong Woo , Kim Keon Jung , Kim Seon Jeong
Published: August 2018

Fiber‐shaped microsupercapacitors that have small volume and high flexibility are particularly needed due to the sudden high demand for appropriate power sources for wearable electronics, smart textiles, and microrobotics. For commercialization of fiber supercapacitors, an economical and mass‐producible fabrication process is required. However, most wet‐spun fiber supercapacitors are graphene‐based electrodes that require complicated and dangerous post‐treatment, such as using heat and chemical reaction. Here, continuous wet‐spun fiber supercapacitors composed of manganese dioxide (MnO2), carbon nanotube (CNT), and platinum nanoparticle (PtNP) are fabricated by a simple one‐step process. Low equivalent series resistance of 2.8 kΩ at 1 kHz and capacitance of 53.1 mF cm−2 are achieved from the MnO2/PtNP fiber supercapacitor. Because of good electrical conductivity, the rate capability remains at 60% from 10 to 100 mV s−1 in the three‐electrode system. The wet‐spun fiber supercapacitors and their manufacturing process are industrially useful because they have enhanced conductivity and electrochemical performance, can be mass‐produced in a simple manner, and can be used in various fields, such as fiber‐type batteries and solar cells, by altering the functional active materials.
Plasmonic Detection of Carbohydrate‐Mediated Biological Events
Authors: García Isabel , Mosquera Jesús , Plou Javier , Liz‐Marzán Luis M.
Published: August 2018

The incorporation of nanomaterials in glycoscience research enables the design of highly selective and sensitive bioanalytical devices for the detection of disease‐associated biomarkers. In particular, localized surface plasmon resonance (LSPR) and surface enhanced Raman scattering (SERS) spectroscopies are powerful biosensing techniques that employ metallic nanostructures to achieve efficient detection of biomolecules. Herein, the most recent achievements are reviewed toward the use of plasmonic nanomaterials together with glycans or glycan‐interacting moieties, to detect carbohydrate‐mediated biological interactions. The review thus focuses on the use of novel optical nanosensors, mainly LSPR and SERS, for the detection of saccharides, lectins, viruses, bacteria, and even whole eukaryotic cells.
Occupational exposure to flour dust and the risk of head and neck cancer
Authors: Carton Matthieu , Menvielle Gwenn , Cyr Diane , Sanchez Marie , Pilorget Corinne , Guizard Anne‐Valérie , Stücker Isabelle , Luce Danièle ,   for the Icare Study Group
Published: August 2018

Background

To investigate the association between head and neck squamous cell cancer (HNSCC) risk and occupational exposure to flour dust in women and men, using data from ICARE, a French population‐based case‐control study.

Methods

The analysis included 2053 cases of HNSCC and 3507 controls. Lifelong occupational history was collected. A job‐exposure matrix was used to assess exposure to flour dust. Odds‐ratios (ORs) and 95% confidence intervals (CI), adjusted for smoking, alcohol drinking, and asbestos exposure, were estimated with logistic regression models.

Results

Ever exposure to flour dust was associated with elevated ORs in women (OR = 2.15, 95%CI: 1.01 4.55) and in men (OR = 1.55, 95%CI: 1.11 2.17). In women, the risk increased with the probability, the duration, and the cumulative level of exposure. No dose‐response relationships were observed in men.

Conclusions

Although the results were less conclusive in men than in women, overall, these findings provide some support to the hypothesis of a role of flour dust in the occurrence of HNSCC.
Chelation‐Assisted C−N Cross‐Coupling between Picolinamides and Aryl Boronic Acids under Nickel Catalysis
Authors: Xiao Zhen , Shu Sihao , Lin Yi , Zhang Qian , Ren Peng , Li Dong
Published: August 2018

A nickel‐catalyzed C−N cross‐coupling between picolinamides and aryl boronic acids was developed. It was promoted by the chelation assistance of picolinyl group without the use of ligands. The reaction proceeded under simple and mild conditions. It was applicable to various picolinamides as well as aryl boronic acids, providing the unsymmetrical N‐aryl tertiary amides in moderate to good yields.
Ability of suvorexant to prevent delirium in patients in the intensive care unit: a randomized controlled trial
Authors: Azuma Kazunari , Takaesu Yoshikazu , Soeda Hiroshi , Iguchi Aki , Uchida Kotaro , Ohta Shoichi , Mishima Shiro , Inoue Takeshi , Inoue Yuichi , Oda Jun
Published: August 2018

Aim

There are no effective, tolerable, and established medications for preventing delirium in critically ill patients admitted to the intensive care unit (ICU). We investigated whether suvorexant was effective in preventing ICU delirium.

Methods

This randomized controlled study evaluated 70 adult patients (age ≥20 years) admitted to the mixed medical ICU of the Tokyo Medical University Hospital (Tokyo, Japan) between May 2015 and February 2017. Patients were randomized using a sealed envelope method to receive either suvorexant (n = 34; 15 mg for elderly patients and 20 mg for younger adults) or conventional treatment (n = 36) for a 7‐day period. The primary outcome was delirium incidence based on the definition in the 5th edition of the Diagnostic and Statistical Manual of Mental Disorders.

Results

No significant between‐group differences were observed in the demographic or clinical characteristics. Kaplan−Meier estimates revealed that time to delirium onset was significantly longer in the suvorexant group than in the conventional group (P < 0.05).

Conclusion

Suvorexant might be effective in preventing delirium in ICU patients.