bluuebunny/crossref_metadata_2025 huggingface dataset:
Rolling origami of vanadium dioxide nanomembranes for enhanced multi-level solar modulation
Authors: Li Xing , Cao Cuicui , Liu Chang , He Wenhao , Wu Kaibo , Wang Yang , Xu Borui , Tian Ziao , Song Enming , Cui Jizhai , Huang Gaoshan , Zheng Changlin , Di Zengfeng , Cao Xun , Mei Yongfeng
Published: July 2022

Thermochromic window develops as a competitive solution for carbon emissions due to comprehensive advantages of its passivity and effective utilization of energy. How to further enhance the solar modulation (ΔTsol) of thermochromic windows while ensuring high luminous transmittance (Tlum) becomes the latest challenge to touch the limit of energy efficiency. Here, we demonstrated rolling origami of vanadium dioxide (VO2) nanomembranes (NMs), and designed a smart window (SW) combining mechanochromism with thermochromism to enhance multi-level solar modulation. The mechanochromism is applied by the temperature-controlled regulation of rolled-up SWs in a wide range of radiation, which benefits from effective strain adjustment in VO2 NMs upon the phase transition. Under geometry design and optimization, the rolled-up SW with high ΔTsol (42.41%) and Tlum (61.01%) is achieved for the modulation of indoor temperature self-adapted to seasons. Furthermore, such rolled-up SW enables high infrared reflectance after triggered phase transition and acts as a smart lens protective cover for high power radiation, which can remain high transmittance under normal operation. This work supports the feasibility and superiority of rolling origami technology in SWs and lens protection, which promises broad interest and practical applications of self-adapting devices and systems for smart building, intelligent sensors, and actuators with the perspective of energy efficiency.
Outcomes of total hip arthroplasty with a standard prosthesis for the affected hip in patients with poliomyelitis sequela: A mid-term retrospective follow-up study
Authors: Shi lihan , Che Guangwei , Huang Yong , Yi Min , Kang Pengde
Published: July 2022

Introduction: Total hip arthroplasty for poliomyelitis sequelae could be a technical challenge due to the higher risk for prosthetic dislocation and degenerative changes in the affected limbs. This study aimed to analyse the mid-term outcomes of primary total hip arthroplasty on the affected hip with standard prosthesis.Materials and Methods: From January 2008 to January 2018, 32 patients with poliomyelitis sequela underwent total hip arthroplasty on the affected hip with standard prosthesis. Clinical and radiographical outcomes, complications, and prosthesis survival rates were evaluated.Results: After a mean follow-up of 6.3 (2.8–11.5) years, the Harris Hip Score, University of California Los Angeles activity level rating, and 12-item Short Form Health Survey Questionnaire scale score significantly improved. The abduction and flexion motions of the hip joint improved dramatically, and the visual analogue scale pain score decreased significantly.The leg length discrepancy was effectively corrected. During the follow-up, one patient experienced prosthetic dislocation, one underwent revision surgery due to acetabular component loosening, two had osteolysis, four had heterotopic ossification, two experienced transient sciatic nerve palsy, and one had intermuscular vein thrombosis. The prosthesis survival rate was 95.7%, at 4.5 years postoperatively.No periprosthetic infection occurred.Conclusion: Total hip arthroplasty with standard prosthesis could be an effective treatment for hip arthropathy on the affected hip of patients with poliomyelitis sequela, resulting in good clinical outcomes and few complications. Constrained liner and dual mobility articulation are not recommended unless the hip muscle strength of the abductor is < III.
N-acetyl cysteine: A new look at its effect on PTZ-induced convulsions
Authors: Egilmez Cansu Bilister , Pazarlar Burcu Azak , Erdogan Mumin Alper , Erbas Oytun
Published: July 2022

Introduction /Aim:
Epilepsy is still widely investigated as a common neurological disease requiring pharmacologically effective agents. N-acetyl cysteine (NAC), the acetyl derivative of cysteine, has become a remarkable molecule with its role in both antioxidant and glutaminergic modulation. There are many points and processes waiting to be revealed regarding the role of NAC in epilepsy.
Materials and Methods
In this study, pentylenetetrazole (PTZ) was administrated to induce seizures. 30 minutes before the seizure-induced procedure, N-acetyl cysteine (NAC) was administered by intraperitoneally at doses of 300 and 600 mg/kg as pretreatment. There are 2 groups designed independently of each other with PTZ doses applied at different doses. These groups were formed in such a way that we evaluated the spike percentage with electroencephalography following 35 mg/kg PTZ, and behavioral observation following 70 mg/kg PTZ. As a biochemical analysis, malondialdehyde (MDA) which is an indicator of lipid peroxidation, was evaluated and superoxide dismutase (SOD) enzyme level was analyzed.
Results
There was a dose-dependent reduction in seizure stage and prolonged onset time of the first myoclonic jerk in rats with N-acetylcysteine pretreatment. EEG recordings resulted in a dose-dependent decrease in spike percentages. Both doses improved MDA and SOD levels, further the results indicate that the higher dose of NAC (600 mg/kg) was more effective.
Conclusion
In the light of all our findings, we can report that N-acetyl cysteine has been shown to be promising with its reducing effect on convulsions. In line with these results, it is obvious that it has a beneficial effect by preventing oxidative stress. Detailed and comparative studies are needed on the convulsion-reducing effect of N acetyl cysteine in epilepsy.
Association of Chronic Kidney Disease with Prior Tinnitus: A Case-Control Study
Authors: Hung Shih-Han , Xirasagar Sudha , Cheng Yen-Fu , Kuo Nai-Wen , Lin Herng-Ching
Published: July 2022

This study aims to explore the relationship between prior tinnitus and the occurrence of chronic kidney disease (CKD) using a nationwide, population-based case-control study. We used data from the Taiwan National Health Insurance Research Database to explore the association of CKD with tinnitus. We identified 15,314 patients aged ≥ 40 years old with a first-time diagnosis of CKD as cases. We used propensity-scored matching to select 45,942 controls (1:3 ratio). We performed multivariate logistic regression to estimate the odds ratio (OR) of a prior tinnitus diagnosis among the CKD group vs control group. Analysis showed that 770 (1.26%) out of the 61,256 sampled patients had previously diagnosed tinnitus. Chi-square test revealed a significant difference in the rate of previously diagnosed tinnitus between cases and controls (3.86% vs. 0.93%, p<0.001). Univariate logistic regression analysis showed an OR of prior tinnitus for cases of 10.249 (95% confidence interval [CI]: (8.662 ~ 12.126)) relative to controls. In adjsuted analysis, cases were more likely than controls to have a prior diagnosis of tinnitus (OR=10.970, 95% CI=9.255 ~ 13.004, p<0.001) after adjusting for age, sex, monthly income, geographic location, urbanization level, hypertension, diabetes, coronary heart disease, hyperlipidemia, obesity and autoimmune disease. Our study shows that persons with tinnitus are at higher risk of a subsequent diagnosis of CKD. Patients diagnosed with tinnitus may benefit from proactive measures to prevent CKD and detect it early through lifestyle modifications and regular renal function examinations regardless of CKD-related symptoms.
Wnt/PCP-YAP-BIRC2 axis maintains cartilage stem/progenitor cell homeostasis in osteoarthritis
Authors: Zhang Lina , Wang Xinxing , Xia Guang , Huang Junjie , Wen Zi , Liang Chi , Cao Xu , Wu Song
Published: July 2022

Background
The cartilage stem/progenitor cells (CSPCs) play a critical role in maintaining cartilage homeostasis. However, the regulation of CSPC function in the microenvironment of Osteoarthritis (OA) is not fully understood.
Methods
The joint fluid of 10 OA patients were collected and analyzed for WNT signaling. CSPCs derived from these patients were isolated, identified, and evaluated for cellular functions. The effect of non-canonical WNT signaling and Yes-associated protein (YAP) expression on CSPCs was investigated in vitro. The OA rat model was established by Hulth’s method. Lentivirus-mediated YAP (Lv-YAP) or lentivirus-mediated YAP RNAi (Lv-YAP-RNAi) was injected intra-articularly to modulate YAP expression in rat joint. In addition, allogeneic CSPCs overexpressing or silencing YAP were transplanted by intra-articularly injection. We also evaluated the functions of CSPC and the OA-related cartilage phenotype in the rat model. Finally, the transcriptome of OA-CSPCs overexpressing YAP was examined to explore the downstream targets of YAP in CSPC.
Results
OA-CSPCs exhibited impaired function in the microenvironment dominated by Wnt/β-catenin signaling and activated function in Wnt/PCP signaling. Wnt5A/B improved the proliferative activity and migration ability of OA-CSPCs. In OA-CSPCs, Wnt/PCP signaling upregulated YAP, which maintained the homeostasis and functions of CSPCs. Upregulation of YAP in the joint delayed OA progression and improved the cartilage regeneration capacity of CSPCs. Using transcriptomic analysis, we found that YAP regulates CSPC function by upregulating Baculoviral IAP repeat-containing 2 (BIRC2). Furthermore, knockdown of BIRC2 significantly impaired the cellular functions of CSPCs and largely blocked the regulation of YAP on CSPCs.
Conclusion
In this study, dysregulation of the Wnt/PCP-YAP-BIRC2 signaling axis contributes to OA-CSPC dysfunction, impairs cartilage's intrinsic reparative ability and accelerates OA progression. This provides a potential therapeutic target for OA.
Successful induction of artificial lactation in non-pregnant gilts
Authors: Cordeiro Ágatha Decroix , Conterato Ana Júlia , Bianchi Ivan , Dartora Débora Lis , Zanella Ricardo , Marques Mariana Groke , Gasperin Bernardo , Lucia Thomaz
Published: July 2022

The increase in litter resulted in increased demand for milk in farrowing rooms to improve piglet survival. This study tested a protocol for induction of artificial lactation (AL) in non-pregnant gilts as a mean to supply milk to newborn piglets. In Experiment I, five gilts received 10 mg estradiol cypionate (EC) on the last day of estrus expression (D0), 10 mg EC and 300 mg long-acting progesterone (P4) on D26, and two doses of a prostaglandin F2α analogue (PGF) I.M. on D36 (0.53 mg each, 12 h apart). Blood was collected on D12, D19, D26 and D33. Milk secretion occurred in all treated gilts 24 h after the PGF administration, lasting at least 8 d. Milk samples were collected from D37 to D45. The circulatory P4 concentration was lower on D12 than subsequently (P < 0.05), but the estradiol concentration did not differ (P > 0.05). The milk produced during the AL was generally richer in protein and poorer in fat than the milk produced during the lactation of a control sow, but both concentrations were only altered near to the 3rd d of the AL. In Experiment II, the same protocol for induction of AL was administered to two gilts. After milk secretion started, each gilt received four 5-d old piglets fostered from other litters. The piglets were nursed for 22 d and weaned weighing approximately 5 kg. Considering both experiments, AL was induced in all treated gilts and the milk produced was capable to nurture fostered piglets.
Improved outcome of adult T-cell leukemia-lymphoma with cord blood transplantation: a nationwide retrospective study
Authors: Tokunaga Masahito , Nakano Nobuaki , Fuji Shigeo , Wake Atsushi , Utsunomiya Atae , Ito Ayumu , Eto Tetsuya , Kawakita Toshiro , Mori Yasuo , Moriuchi Yukiyoshi , Suehiro Youko , Miyazaki Yasuhiko , Uchida Naoyuki , Sawayama Yasushi , Ishitsuka Kenji , Kanda Junya , Kimura Takafumi , Ichinohe Tatsuo , Atsuta Yoshiko , Fukuda Takahiro , Yoshimitsu Makoto , Kato Koji
Published: July 2022

We examined 1495 patients with adult T-cell leukemia-lymphoma (ATL) who underwent their first allogeneic hematopoietic cell transplantation (HCT) in 2008–2017. We evaluated cord blood (CB) transplantation (CBT) outcomes in two groups, 2008–2012 and 2013–2017, using a propensity score-matched (PSM) analysis. The median age at HCT was 61 years in patients who received CBT in 2013–2017. After PSM analysis, CBT patients in 2008–2012 had high transplantation-related mortality (TRM) (2-year TRM: 45.6%) and poor overall survival (OS) (2-year OS: 30.2%). In 2013–2017, 2-year OS (28.0% vs. 35.7%, respectively; P = 0.273), 2-year ATL-related mortality (35.7% vs. 30.7%, respectively; P = 0.377), and 2-year TRM (36.4% vs. 33.5%, respectively; P = 0.806) were comparable between patients with CBT and those with HCT from other donor sources. We found more anti-human leukocyte antigen antibody testing, infused CB total nucleated cells, and patients achieving neutrophil engraftment as well as fewer infectious disease deaths among CBT patients in 2013–2017 than in 2008–2012, which may have contributed to the decrease in TRM. In conclusion, OS and TRM following CBT improved despite the advanced age of ATL patients, and CB is now a reasonable alternative donor source for ATL.
Highly efficient glycerol acetalization to solketal over Keggin type heteropolyacid supported on ionic liquid decorated hierarchical faujasite zeolite, prepared through a novel approach
Authors: Tarighi Sara , Sadjadi Samahe , Delangiz Motahareh
Published: July 2022

To handle huge amount of glycerol produced in biodiesel industry, glycerol is transformed to value-added products. In this regard, glycerol acetalization to solketal is industrially attractive. As in this process various by-products can be formed, designing highly selective catalysts is of great importance. In this line, we wish to report a novel catalyst that benefits from strong acidity, high specific surface area and thermal stability, which can selectively form solketal in glycerol acetalization. To prepare the catalyst, hierarchical zeolite was prepared via a novel method, in which partially delaminated NaY was treated with Pluronic®F-127 and then reacted with NH4NO3 to furnish the H-form zeolite. Hierarchical faujasite was then achieved through calcination and template removal. Subsequently, it was functionalized with ionic liquid and used for the immobilization of heteropolyacid. The results indicated the importance of the mesoprosity of zeolite and the presense of ionic liquid functionality for achiveing high solketal yield. Moreover, among three investigated heteropolyacids, phosphomolybdic acid exhibited the highest catalytic activity. In fact, using 10 wt.% catalyst at 55°C and glycerol to acetone molar ratio of 1: 20, solketal with yield of 98% was furnished under solvent-less condition. Besides, the catalyst was recyclable with low leaching of heteropolyacid.
Oncogenic role of a long-term high-fat diet-induced DNM1 in hepatocellular carcinoma
Authors: Wu Hsing-Ju , Chou Dev-Aur , Chen Po-Ming , Chu Pei-Yi , Tang Feng-Yao , Chiang En-Pei Isabel
Published: July 2022

Background:Dietary patterns play important roles in the occurrence and development of numerous human cancers including hepatocellular carcinoma (HCC). In this study, we explored and investigated the potential tumor-promoting genes in mice received high-fat diet (HFD).Methods:We initiated the process by analyzing liver gene expression profile of mice received HFD downloaded from Gene Expression Omnibus (GEO No. GSE108169). Differentially overexpressed genes were assembled and analyzed for the clinical prognosis and biological functions in human cancer databases. The Cancer Genome Atlas Liver Hepatocellular Carcinoma (TCGA-LIHC) were screened by The University of ALabama at Birmingham CANcer data analysis Portal (UALCAN), Human Protein Atlas (HPA), LinkedOmics analysis, TIMER2.0, and Q-omics analysis. Survival analyses were performed to examine the significance for the newly identified biomarkers for HCC.Results: Among the top 10 overexpressing genes in HFD-fed mice liver, a neuron-specific protein, dynamin 1 (DNM1) was identified as a significant prognostic predictor for poor HCC survival examined by UALCAN. Using HPA, we discovered that normal liver tissue does not express DNM1 protein whereas it was found in 30% HCC, and abundant DNM1 protein was detected in HCC cell cytoplasm and membrane. DNM1 gene expression is positively correlated some genes enhanced epithelial-mesenchymal transition (EMT), proliferation, and neural transduction signaling, and its negatively correlated genes enhanced certain metabolism and host-defense ability. Furthermore, positive correlations between DNM1 and CD8 T cells, regulatory T cells (Treg), B cells, macrophages, and natural killer (NK) cells were observed, indicating possible associations between DNM1 and infiltrating immune cells. We then identified a common gene, TAR (HIV-1) RNA Binding Protein 1 (TARBP1) by overlapping the differentially downregulated genes of HCC cells with single-guide DNM1 (sgDNM1), short-hairpin DNM1 (shDNM1), and the TCGA DNM1 correlated genes that also correlated significantly with poor overall survival and disease-free survival of HCC. ConclusionsThis is the first study proposing a role of the HFD-induced hepatic DNM1 over-expression might affect tumor development and immune microenvironment in human HCC. The discovery of this novel marker can add insights into the link of high fat diet and HCC, and provide potential therapeutic target pathways for treating HCC. We suggest DNM1 be a potential prognostic biomarker and therapeutic target for HCV-positive human HCC.
On the dynamics of non-spherical test particle in the spatial collinear restricted four-body problem
Authors: Asique Chand , Alhowaity Sawsan , Alhowaity Awatif , Aggarwal Rajiv , SURAJ Md SANAM , Hamam Haneem
Published: July 2022

In the present manuscript, the dynamics of the non-spherical test particle in the spatial collinear restricted four-body problem is presented. Using the numerical methods, the parametric variation of the position of libration points (LPs) is illustrated when the oblateness/prolateness parameters vary in the pre-assumed intervals. Moreover, it is also unveiled that how these parameters affect the stability of the LPs and the regions of motion. For all the LPs, we have shown their nature by classifying
them not only in two category i.e., as linearly stable and unstable but also as maxima, index-1, and index-2 saddles.The performed numerical investigations strongly suggest that the oblateness/prolateness parameters are indeed very influential factors in this dynamical model.
The roles of land-ocean geometry and ocean heat transport on continental wetness and its response to climate change
Authors: Scheff Jacob , Frierson Dargan M. W.
Published: July 2022

Terrestrial hydroclimate change projections in full-complexity climate models are characterized by a patchwork of regional drying and wetting responses for most variables, even as temperatures warm and evaporative demand increases. Yet, certain geologic proxies suggest that during warm climates of the deep past, the continents were very wet. Recent studies also find that climate models do not reproduce the observed enhancement of tropical precipitation by the presence of land.

Motivated by this gap in understanding, we explore continental hydroclimates and their responses to global warming in an atmospheric model over several different idealized land-ocean configurations, with ocean heat transport turned on and off. We find that the presence and width of Mediterranean-like subtropical seaways play key roles in wetting the continents, and that the cooling of the tropical ocean by heat transport further wets the tropical continent(s) in a thermally direct response. Critically, configurations with drier (wetter) tropical continents tend to further dry (wet) them with global warming, and these responses are strongly concave-down nonlinear. We also briefly test the roles of land parameters, astronomical choices, and topography.
Association of Dyslipidemia, Renal dysfunction, and Uricemia with HPV mediated Cervical Cancer
Authors: Kushwah Atar Singh , Mishra Rajnikant , Srivast Kirti , Mishra Shambhavi , Banerjee Monisha
Published: July 2022

Recently obesity, dyslipidemia and uricemia has been implemented in cancer progression and development. Therefore, in the present study lipid profile, renal function and uric acid levels have been evaluated and their association has been assessed in HPV-mediated cervical cancer (CaCx) patients. Women diagnosed with CaCx were tested for HPV infection using conventional PCR. Anthro-demographic and clinicopathological characteristics were recorded and samples from patients (n = 103) and healthy women (n = 108) were analyzed for dyslipidemia (total cholesterol, TC; triglycerides, TG; high-density lipoprotein, HDL; low-density lipoprotein, LDL levels), serum urea, creatinine and uric acid using commercially kits. All statistical analysis was done using SPSS (ver.21.0) and GraphPad. Out of 103 CaCx patients, 86 were HPV + ve and 17 were HPV-ve. BMI was associated with HPV + ve with a higher risk (1.55 folds) while cholesterol was relatively significant in HPV-ve cases with a 1.01 folds crude OR. TG, HDL and LDL were found significantly associated with an increased adjusted OR in HPV + ve cases. Urea levels were found significantly higher in HPV + ve as compared to HPV-ve (1.63 vs 1.12 folds Crude OR). while the adjusted OR became deceased in HPV + ve CaCx patients (1.10) compared to HPV-ve CaCx patients (1.31). Both creatinine and uric acid showed significantly higher adjusted OR (11.07, 1.53) in HPV + ve cases as compared to HPV-ve (10.37, 1.46). Dyslipidemia, renal dysfunction, and uricemia were found clinically significant in CaCx patients. Therefore, TG, HDL, LDL, serum urea, creatinine, and uric acid can be used as prognostic biomarkers for HPV-mediated cervical cancer.
Patient Journey for Hypertension and Dyslipidemia in Saudi Arabia: Highlighting the Evidence Gaps
Authors: Amir Ashraf , Alasnag Mirvat , Al-Raddadi Rajaa , Al-Bassam Tawfik , Saeed Kanwal , Yazıcıoğlu Mehmet , Shabana Ayman
Published: July 2022

Background
In recent years, Saudi Arabia has witnessed staggering rates of hypertension and dyslipidemia- related cardiovascular (CV) deaths, overburdening the healthcare ecosystem of the country. Appropriate public health interventions can be devised through quantitative mapping of evidence. Identification of potential data gaps can prioritize future research needs and develop a ‘best-fit’ framework for patient-centric management of hypertension and dyslipidemia.
Methods
This review quantified data gaps in the prevalence and key epidemiological touchpoints of the patient journey including awareness, screening, diagnosis, treatment, adherence, and control in patients suffering from hypertension and dyslipidemia in Saudi Arabia. Studies published in English between January 2010–December 2021 were identified through a structured search on MEDLINE, Embase, BIOSIS and PubMed databases. An unstructured search on public and government websites including Saudi Ministry of Health without date limits was carried out to fill data gaps. After exclusion of studies based on pre-defined criteria, a total of 14 studies on hypertension, 12 studies and one anecdotal evidence for dyslipidemia were included in the final analyses.
Results
The prevalence of hypertension was reported to be 14.8–41.8% while that for dyslipidemia was 12.5–62.0%, respectively. The screening rate for hypertension was 100.0% as revealed by the nationwide surveys. Among hypertensive patients, only 27.6–61.1% patients were aware of their condition, 42.2% patients underwent diagnosis, 27.9–78.9% patients received antihypertension treatment, 22.5% patients adhered to treatment medication while blood pressure (BP) control was achieved in 17.0–45.0% patients. Likewise, among patients with dyslipidemia, 10.5–47.3% patients were aware of their condition, 34.6% patients were screened and 17.8% underwent diagnosis. Although high treatment rates ranging from 40.0–94.0% were reported, medication adherence recorded was 45.0–77.4% among the treated patients. The overall control rates ranged from 28.0–41.5%.
Conclusions
The study findings highlight evidence gaps along key touchpoints of patient journey touchpoints. Reinforcing the efforts for high-quality evidence-based research at a national level may pave a path for better resource utilization and provide guidance to practice and amend health policies for patients, healthcare practitioners (HCPs) and healthcare policy makers for better patient outcomes in Saudi Arabia.
Static and free vibration analysis of gravity dam under the influence of hydrostatic pressure using ANSYS finite element models
Authors: name Pandimani no family , Vipparthy Ravindra
Published: July 2022

Dams are considered to be very important structures as they play an important role in the economic and social development of the area in which it is being constructed as well as utilized for hydropower generation. The concrete gravity dam is a solid structure that retains its stability against the design loads through its self-weight alone. The dam considered in this study is a structure of the Indirasagar polavaram gravity dam which is located in the village called Ramayyapeta comes under the West Godavari District, Andhra Pradesh. In this study, the finite element (FE) method is employed to numerically analyze the 2-D concrete gravity dam. The main objective of this study is to perform a linear FE analysis of the Indirasagar Polavaram gravity dam by varying the upstream hydrostatic pressure with constant downstream tailwater pressure. In the static analysis parameters like displacements, stresses and strains are assessed at each node, and their corresponding distributions are noticed. Subsequently, in the dynamic analysis approach, only free vibration analysis (Modal analysis) is done by considering only the dam's weight, the first five-mode shapes and their respective natural frequencies are extracted using ANSYS. The linear material behavior of the dam is modeled using the quadrilateral 4 node PLANE182 elements and the hydrostatic pressure is applied as triangular distribution. From the numerical analysis, it is concluded that the maximum tensile stresses are accumulated at the heel portion of the dam for cases 1 to 4, whereas it is observed distributed along the dam base for the rest of the cases. The lateral displacement and strain are observed maximum for case 1. The First mode's natural frequency of 5.81 Hz is ascertained and the maximum frequency and displacement are produced under the fifth mode.
Generating and Choosing Organisations for Multi-Agent Systems
Authors: Amaral Cleber Jorge , Hübner Jomi Fred , Cranefield Stephen
Published: July 2022

The design of organisations is a complex and laborious task. It is the subject of recent studies, which define models to automatically perform this task. However, existing models constrain the space of possible solutions by requiring a priori definitions of organisational roles and usually are not suitable for planning resource use. This paper presents GoOrg, a model that uses as input a set of goals and a set of available agents to generate different arrangements of organisational structures made up of synthesised organisational positions. The most distinguishing characteristics of GoOrg are the use of organisational positions instead of roles and that positions are automatically synthesised rather than required as a priori defined inputs. GoOrg qualifies the generated structures according to multiple attributes; These characteristics facilitate the parametrisation, the use for resource planning and the chance of finding feasible solutions. This paper also introduces two model specialisations, which define processes and constraints that illustrate how GoOrg suits different domains. Among aspects that surround an organisation design, this paper discusses models' input, agents' abstractions and procedures for adapting the organisation during its life-cycle.
Self-DNA accumulation as a risk factor for accelerating the pathogenesis of rheumatoid arthritis in elderly individuals
Authors: Luo Weidan , Wong Vincent Kam Wai
Published: July 2022

Ageing is an unavoidable process in humans and a major factor for the increasing risk of various diseases. In the United States, more than 50% of rheumatoid arthritis patients are middle-aged or elderly, but the risk factors and mechanisms by which ageing increases the incidence of rheumatoid arthritis are not known. It has been suggested that the accumulation of DNA fragments increases the risk of autoimmune diseases, such as systemic lupus erythematosus. DNA fragments are a common nucleic acid metabolite in ageing organisms as well as in the serum of humans and animals with rheumatoid arthritis; therefore, we hypothesize that DNA fragments are one of the factors contributing to the development of rheumatoid arthritis due to ageing. First, we analysed two in vitro DNA damage response models by using a gene silencing approach and determined that the DNA fragment clearance gene TREX1 can regulate inflammatory factor release in normal cells. Second, after TREX1 expression was knocked down locally or systemically in rats via the Cre-LoxP system and compared with that in AIA (adjuvant-induced arthritis) model rats treated with AAV-TREX1, it was determined that DNA fragments can result in manifestations of arthritis and abnormal activation of the immune system in rats. These results, including the low expression of the TREX1 gene in clinical patient and AIA model samples and the results of immunohistochemical, Western blot, and transcriptome analyses, revealed that the TREX1 gene can regulate cellular senescence-associated secretory phenotype (SASP)-related manifestations and showed that dysregulation of c-Jun and c-Fos, components of the TREX1 transcription factor AP-1, is associated with SASP induction. Finally, it was confirmed in vitro that different causes of decreased c-Fos expression can inhibit TREX1 expression. These DNA fragments are potent producers of inflammation-releasing mediators, and TREX1 is an effective degrader of DNA fragments; it is also a key gene that regulates cellular immunity and ageing. Therefore, effectively clearing excess DNA fragments from the body and ensuring the health of senescent cells may be a potential prevention strategy for RA.
The Quality Problems in Low İrradiance at Grid Connected PV Solar System
Authors: adak suleyman
Published: July 2022

Photovoltaic (PV) energy is one of the main topics that have attracted the attention of researchers in recent years. The use of solar energy is increasing rapidly in the world. Although PV energy has many advantages, it has some disadvantages. Among these disadvantages, power factor (PF) and Total Harmonic Distortion (THD) issues are discussed in this article. PF and THD are dependent on the radiation values. The solar inverter output voltage and current waveform should be in sinusoidal waveform. However, the sinusoidal waveform of current and voltage lose their sinusoidal characteristics due to non-linear loads on grid-connected solar system. Harmonic components often occur in grid-connected solar PV systems. In addition, at low irradiance the amplitude of harmonic components increases, whereas the power factor of the PV system decreases. Low power factor and high amplitude of harmonics cause the efficiency of the solar system to decrease. PF and THD values were measured in a particular cloudy day for analysis. The grid-connected PV system was modeled by using Matlab /simulation program and carried out the analysis of the solar PV system. Thus, the analytical expression of the PF and THDI dependent on irradiation were found with a new method by using statistical package for the social sciences (SPSS) program and curve fitting method.
Fault Detection and Diagnosis of Induction Motor Using Hybrid POA – SNNLA technique
Authors: Kumar R. Senthil , Rajesh P. , Shajin Francis H.
Published: July 2022

The authors have requested that this preprint be removed from Research Square.
Methylphenidate dose-response in children with ADHD: Evidence from a double-blind, randomized placebo-controlled titration trial
Authors: Vertessen Karen , Luman Marjolein , Swanson James M. , Bottelier Marco , Stoffelsen Reino , Bet Pierre , Wisse Annemiek , Twisk Jos W.R. , Oosterlaan Jaap
Published: July 2022

Background
Methylphenidate (MPH) is highly efficacious in reducing symptoms of attention-deficit/hyperactivity disorder (ADHD) in children. Generally higher doses are found to result in better symptom control, however, it remains unclear whether this pattern can be observed at the individual level, given the large heterogeneity in individual dose-response relationships and observed placebo responses.
Methods
A double-blind, randomized, placebo-controlled cross-over trial was used to compare weekly treatment with placebo and 5, 10, 15 and 20 mg of MPH twice daily on parent and teacher ratings of child ADHD symptoms and side effects. Participants were 5–13 year old children with a DSM-5 diagnosis of ADHD (N = 45). MPH response was assessed at group and individual levels and predictors of individual dose-response curves were examined.
Results
Mixed model analysis showed positive linear dose-response curves at group level for parent and teacher rated ADHD symptoms and parent rated side effects, but not for teacher rated side effects. Teachers reported all dosages to improve ADHD symptoms compared to placebo, while parents only reported > 5 mg/dose as effective. At the individual level, most (73–88%) children showed positive linear dose-response curves. Higher severity of hyperactive-impulsive symptoms and lower internalizing problems, lower weight, younger age and more positive opinions towards diagnosis and medication partly predicted steeper linear individual dose-response curves.
Conclusions
Our study confirms that higher doses of MPH yield greater symptom control at a group level. However, large interindividual variation in the dose-response relationship was found and higher doses did not lead to greater symptom improvement for all children.
Reusable titania-SBA-15 photocatalyst synthesized by different silica/titania ratios for enhancing methylene blue photodegradation
Authors: Göl Sevgi Can , Akbay Elif
Published: July 2022

In this study, a series of TiO2/SBA-15 photocatalysts were synthesized with different Si/Ti ratios by a one-step hydrothermal method with TiO2 nano-powder as a titanium source. These materials were characterized by XRD, SEM-EDX, N2 adsorption-desorption isotherms-desorption isotherms, XRF, and UV-DRS analysis. During the synthesis of TiO2/SBA-15s, the SBA-15 pore structure and channels did not deteriorate, and the Si/Ti molar ratios are close to the expected nominal ratios. SBA-15 and TiO2/SBA-15s exhibited a uniform- narrow pore size distribution, but TiO2/SBA-15s pore size shifted to a smaller range, and the BET area values of TiO2/SBA-15s materials are in the range of the 621–583 m2/g. TiO2 nanocrystals into the SBA-15 mesopores walls wall up to the ratio of Si/Ti = 16. With high TiO2 loading of that value, clogging occurs in the SBA-15 pores. The optical band gap energies were significantly blue-shifted which is the quantization effects improving the photocatalytic activities Photocatalytic activities of TiO2/SBA-15s were evaluated by degradation of methylene blue under UV-light irradiation at constant TiO2 content. The highest efficiency was obtained in the TiO2/SBA-15 (16) photocatalyst at 79.6%, and all efficiencies in synthesized photocatalyst are higher than bulk TiO2 photocatalyst activity (27.52%) due to the poor dispersion of active phases. Reused photocatalyst has no activity losses for five runs and may be used for long periods without loss of activity. For the stability of the photocatalyst, a combination of XRD, SEM, and N2 adsorption-desorption isotherms was employed after the fifth run. These results demonstrate that the photocatalyst activity and stability are good, and photocatalytic activity was sustainable after reuse for several cycles.
The Physical Properties Study of The Hybrid One-Part Alkali-Activated Mortar
Authors: Yusslee Eddy Mohd Fairuz Mohd , Beskhyroun Sherif
Published: July 2022

One-part alkali-activated materials (AAMs) are an alternative material to respond to the shortcoming of the conventional two-part systems. One-part AAMs are more practical and safer to handle from transporting to the casting stage on site. It can be applied in the form of paste, mortar, and concrete, providing more options than an ordinary cement binder. The most common aluminosilicate precursors sources for the one-part AAMs are the combination or single raw material of fly ash, ground granulated blast furnace slag and metakaolin. However, it was found that the one-part AAMs experienced high porosity levels primarily due to their inconsistent pore structures that affect their long-term performance. One-part AAMs mortar is one of the cementitious products used as concrete repair materials that may be affected by these weaknesses. Nevertheless, the combination of aluminosilicate precursor by-products with the ordinary Portland cement or hybrid AAMs help to develop a robust performance mainly used as a patching product for concrete repair materials. This hybrid one-part AAMs mortar can be composed with other admixtures with a suitable mix design to ensure its stability and useable in the form of a fresh and hardened state. Unlike the ordinary concrete, hybrid one-part AAMs have significantly strengthened growth beyond the 28th day. In this study, the mechanical strength of the mortar increased over time up to 63 N/mm2 at 56 days of curing age, shorter setting time and workable comparable to the control samples. In addition, the water to binder ratio of 3.0 activated the dry mixes and significantly improved the physical and microstructure of the hybrid one-part AAMs mortar.
Does corruption affect private firm performance in Uzbekistan?
Authors: Suyunov Alisher , Amanova Maftuna
Published: July 2022

The study investigates the impact of corruption on private firm performance in Uzbekistan. The results point up a negative relationship between corruption and firms performance in Uzbekistan. We found the perceived corruption deteriorates firms’ performance and decreases firms’ total annual sales by 28.8% in private firms in Uzbekistan. The study enriches existing empirical studies examining the effect of corruption on firm performance in the context of various countries and regions.
Quality of household drinking water and its associated risk factors in flood-prone settings of Northwest Ethiopia: a cross-sectional community-based study.
Authors: Birhan Tsegaye Adane , Destaw Bikes , Dagne Henok , Eyachew Dagnachew , Azanaw Jember , Andualem Zewudu , Dessie Awrajaw , Guyasa Gebisa , Getaneh Alem , Addisu Ayenew , Genet Mengesha , Tadege Garedew , Tesfaye Amensisa Hailu
Published: July 2022

Background: Drinking water quality deterioration is a big issue in many countries which could be a result of many interconnected biological, physical, and chemical factors. The main contaminants of water sources are human excreta, animal waste, and effluent agricultural practices. Even if the source is safe, water may also become faecally contaminated during collection, transportation, storage, and drawing in the home. Furthermore, a better water source does not lead to full health benefits in the absence of improved water storage and sanitation. Therefore, Regular quality control mechanisms need to be in place. The objective of this study is therefore to determine the level of physioco-chemical and bacteriological quality of household drinking water and its associated factors in flood-prone settlements of South Gondar Zone, Ethiopia.Methods: A community-based cross-sectional study was conducted in flood-prone settlements of the South Gondar Zone from January to March 2021. Household water samples were taken from each household using standardized water sampling techniques. Face-to-face interview using structured questionnaires was used to collect socio-economic and behavioral data. Univariate and multivariate analyses were done using logistic regression models.Results: A total of 675 households participated in the study. The prevalence of positive fecal coliform in household water samples in flood-prone settlements of the South Gondar Zone was found to be 62.2% (n=417) with [95% CI (53-60)]. In multivariate analysis, family size [AOR=2.205, 95%CI (1.375-3.536)], presence of latrine [AOR=3.449, 95%CI (1.349-8.823)], and having a separate can to take water from its storage [AOR=0.454, 95%CI (0.249-0.827)] are variables identified as predictors for fecal coliform contamination of household water.Conclusion: In this study, the prevalence of positive fecal coliform household water was high. Family size, the presence of a latrine, and having a separate can to take water from its storage had significant associations with the presence of fecal coliform in household drinking water.
Financial Market Trends as a Part of Regional Development: Manifestations of Behavioral Reactions and Impulses
Authors: Anna Rosokhata Anna , Jasnikowski Adam , Kropyva Viacheslav , Deryzemlia Maksym
Published: July 2022

Since 24 February 2022, a significant number of spheres of human life in Ukraine have been significantly modified. Mass fluctuations in behavior have affected all socio-economic components of society, a clear example of which is the financial sector. These events, which took place in Ukraine on February 24, 2022, were reflected in the behavioral reactions of representatives of other countries, and in some places we can say that the whole world. Investigating behavioral changes in individual countries around the world is a clear example of the analysis of behavior in the digital environment. In this space, you can clearly track the demands of individual consumers in a particular sector of life and economy. Thus, we conducted a research of retrospective empirical comparative analysis of consumer requests in the main sectors of the financial system, taking into account the most trendy words and phrases that are relevant to requests in the Internet environment. The purpose of this work is to evaluate and analyze mass behavioral reactions of people depending on the situation. Justification of the theoretical and practical foundations of mass behavior and their prerequisites. The task of the article is to formulate the main connection between the issues of behavioral impulses of the masses of our society and behavior in general in one or another situation. The article provides an empirical, retrospective and comparative analysis of behavioral impulses in Ukraine in the banking sector and in the world from the standpoint of researching trends and trends in consumer behavior and the formation of behavioral impulses and reactions under their influence. Yes, the experience of Ukraine is compared with the world experience in this field. Research methods are analysis of literary sources, analysis and synthesis, induction and deduction, specification and comparison, graphic method and generalization. The article presents the main fundamental behavioral and socio-economic issues in the banking sector, which in turn shape consumer behavioral changes. The concept of deposit panic and examples of trends that can form it depending on the financial situation of Ukrainian banks are considered. The results of the study can be used in the development of means of influence and regulation of mass management. Development of social studies. Using a behavioral approach in building a socially oriented economy will give more effective results. This work expands the possibilities of using methods of analysis and research of behavioral impulses, socio-economic manifestations in society.
Gender diversity in the boardroom and shareholder wealth maximisation: Evidence from the United Kingdom
Authors: Hasan Fakhrul
Published: July 2022

In this research our aims to provide further evidence in the research area behind the effects of gender diversity in the board room. The empirical consensus is gender diversity increases a firm’s financial performance, and greater financial performance increases dividends and stock price. This research will provide evidence for the direct link between the two. We used FTSE 100 companies across the period 2011-2020. Data analysis shows that FTSE 100 found no relationship between gender and dividends, of 0.01% statistical significance, no relationship or statistical significance between gender and return, and a weak positive correlation of 0.015 statistical significance between gender and EPS. This therefore drawn to the conclusion of given its establishment, constituents of the FTSE 100 are subject to foreseeable levels of performance and profits. Given their size and lack of volatility at that sector of the stock market, that alteration of gender diversity at board level will result in a change in dividend or stock returns and is more likely to be due to more operational aspects of the companies.
Efficiency in the MENA banking industry, the stochastic frontier approach (SFA)
Authors: Rizk Samar
Published: July 2022

The main focus of this paper is the study of efficiency in the Middle Eastern and North African (MENA) banking industries throughout the period 1999-2017. The study of efficiency in many other regions reveals the existence of failures in the allocation of resources for banking sectors which results in the appearance of banking inefficiency in terms of cost. The empirical results, using a parametric cost frontier applied, show a fluctuating yet improving efficiency in the MENA and are used to rank efficiency of banking industries by country over the years (1999- 2017). Promoting a strong and stable banking system reduces uncertainties and systemic risk which leads to greater efficiency. A stable and efficient banking system is then, necessary, for economic development. Since 1990s, and due to reforms required by supervisory authorities, banks in the MENA region have faced many structural changes and have tried to develop their activities by seeking to enter new markets and new sectors of activity in order to adapt to the economic and institutional environment changes by adopting internal and / or external growth strategies. These strategies can increase banks market power and diversify banking industries’ activities in order to achieve efficiency gains.
Studies of $b$-hadrons and quarkonia at LHCb
Authors: Xiang Zhiyu
Published: July 2022

LHCb has productive studies of quarkonia and b-hadrons which provide
essential inputs to study quantum chromodynamics (QCD). In this
proceeding, seven recent results are reported: the observation of a new
excited \Xi_b^0Ξb0
resonance in \Xi_b^-\pi^+Ξb−π+
final states, the new excited B_s^0Bs0
state is observed in B^+K^-B+K−
mass spectrum, the first observation of suppressed semileptonic
B_s^0\to K^-\mu^+\nu_\muBs0→K−μ+νμ
decay, the first observation of the decay B^0\to D^0\bar{D^0}K^+\pi^-B0→D0D0‾K+π−,
the first observation of the Cabibbo-suppressed decay
\Lambda_b^0\to\Lambda_c^+K^+K^-\pi^-Λb0→Λc+K+K−π−,
the first observation of decay, and end this report with the first
search for the doubly heavy baryon \Omega_{bc}^0Ωbc0
and a search for \Xi_{bc}^0Ξbc0
baryon.
Recent results on top quark mass and properties and rare/anomalous top quarks interactions in CMS
Authors: Wuchterl Sebastian
Published: July 2022

The amount of data collected by the CMS experiment at the CERN LHC in the second data taking period provides the possibility to study absolute and differential cross sections of top quark interaction processes with high precision. Utilizing these results, fundamental standard model parameters such as the top quark mass are extracted. Moreover, given standard model measurements are interpreted in the context of beyond the standard model theories.
Recent results on top quark properties and rare or anomalous top quark interactions by CMS are presented in these proceedings. Furthermore, the implications of experimental results to effective field theory are discussed.