bluuebunny/crossref_metadata_2025 huggingface dataset:
Morphine-like Novel Compounds for the Treatment of Depressive Symptoms
Authors: Choudhary Diksha , Kaur Rajwinder , Kumar Bhupinder
Published: September 2023

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Depression is a severe mental disorder characterized by a major imbalance between the levels of neurotransmitters. US11534436 B2 discloses an efficient amount of µ-opioid receptor agonists or their pharmaceutically acceptable salt for efficient treatment of depression. The patent discloses a few new compounds among which compounds 1, 2, 3, 4, and 5 as well as derivatives of basic nucleus A have good µ-opioid receptor agonist activity without risks of opioid addiction or development of addiction withdrawal symptoms. The compounds displayed Emax of 5% to 45% in a GTPγS binding assay while one of the derivatives displayed Emax of 15% to 35% in a GTPγS binding assay. The patent further discloses different embodiments with different potentials. The administration of an effective dose in rats resulted in 125% to 300% efflux of dopamine of baseline. At a dosage of 1-10 mg/kg, the embodiments do not diminish the thermal pain in rodents. Although the patent explored new µ-opioid receptor agonists for the treatment of depressive symptoms, the exhaustive evaluation of toxicity and further mechanisms need to be explored via in vivo models.
Diverse Pharmacological Potential of Pyridazine Analogs against Various Diseases
Authors: Alsaiari Ahad Amer , Almehmadi Mazen M. , Asif Mohammad
Published: September 2023

Pyridazinone analogs possess diverse types of pharmacological activities, such as anticancer, antimicrobial, anticonvulsant, analgesic, anti-inflammatory, antioxidant, antihypertensive, antisecretory, antiulcer, and other useful pharmacological activities. They also possess cyclooxygenase (COX) inhibitors, dipeptidyl peptidase inhibitors, phosphodiesterase inhibitors, glutamate transporter activators, adenosine receptor antagonists, serotonin receptors antagonists, lipooxygenase, cholinesterase, vasodilator, and anesthetics. Pyridazine rings are the essential structure for some marketed drugs, such as pimobendan, levosimendan as a cardiotonic drug, and emorfozan as an analgesic and anti-inflammatory (Non-steroidal anti-inflammatory drug) agent. So, researchers all over the world have paid attention to synthesizing various pyridazinone compounds mainly due to the ease of design and synthesis of different analogs and variables in the pharmacological responses. This review article focuses on the pharmacological activities of different pyridazine analogs.
Advances in Drug Discovery and Design using Computer-aided Molecular Modeling
Authors: Singh Kuldeep , Bhushan Bharat , Singh Bhoopendra
Published: September 2023

Computer-aided molecular modeling is a rapidly emerging technology that is being used to accelerate the discovery and design of new drug therapies. It involves the use of computer algorithms and 3D structures of molecules to predict interactions between molecules and their behavior in the body. This has drastically improved the speed and accuracy of drug discovery and design. Additionally, computer-aided molecular modeling has the potential to reduce costs, increase the quality of data, and identify promising targets for drug development. Through the use of sophisticated methods, such as virtual screening, molecular docking, pharmacophore modeling, and quantitative structure-activity relationships, scientists can achieve higher levels of efficacy and safety for new drugs. Moreover, it can be used to understand the activity of known drugs and simplify the process of formulating, optimizing, and predicting the pharmacokinetics of new and existing drugs. In conclusion, computer-aided molecular modeling is an effective tool to rapidly progress drug discovery and design by predicting the interactions between molecules and anticipating the behavior of new drugs in the body.
Paediatric Palliative Care in a Reference Centre of Inherited Metabolic Diseases
Authors: Saraiva Bárbara Martins , Santos Susana , Ferreira Ana Cristina , Paiva Mafalda
Published: September 2023

Introduction:

Paediatric palliative care (PPC) has a significant role in improving the quality of life of children with life-limiting or life-threatening illnesses, diminishing symptom burden, and providing holistic support to patients and families.
Inherited metabolic diseases (IMD) are a group of heterogeneous diseases that often present with severe neurologic impairment, needing lifelong care and challenging symptom management.

Objective:

Our aim was to characterize the cohort of patients with IMD followed by the paediatric palliative care team (PPCT) and to describe the provision of care provided.

Methods:

The descriptive analysis of demographic, clinical, and care delivery data of a cohort of paediatric patients was carried out with a confirmed diagnosis of IMD, followed in a Reference Centre, in the care of PPCT between 2018 and 2023.

Results:

Thirteen (10%) of a total of 134 patients in the care of PPCT had a confirmed diagnosis of an IMD: 6 mitochondrial, 3 peroxisomal, 3 lysosomal, and 1 pterin metabolism disorder. The median age at referral was 9 years (0-18), the median duration of care was 2 years [2-4], median number of home visits in the last year was 2 [1-4], and median number of outpatient consults was 4 [2 -8].
Twelve patients (92%) had no autonomy in their activities of daily living. Neurologic (100%), gastrointestinal (92%), and respiratory (69%) symptoms were the main focus of care. All patients were polymedicated (5 or more different drugs). Nine (69%) had percutaneous gastrostomy and 2 (15%) had noninvasive ventilation. Median hospital admissions before and after starting care by PPCT were 4 and 1. Moreover, three patients died and one was at home.

Conclusion:

Mitochondrial, lysosomal, and peroxisomal disorders are complex multisystemic diseases that very often have no treatment intended to cure. These patients have a heavy symptom burden and frequent intercurrences. Addressing these symptoms is challenging, but PPC has proven to reduce hospital admissions with consequent improvement in quality of life.
In the future, PPC should be available for all children and families with life-threatening conditions.
SERAC1 Deficiency- A New Phenotype
Authors: Martins Emanuel , Durães João , Nogueira Célia , Gomes João , Vilarinho Laura , Macário Carmo
Published: September 2023

Introduction:

SERAC1 deficiency phenotype range from MEGD(H)EL syndrome, the most severe, to juvenile complicated spastic paraplegia, to adult-onset dystonic features (in only one patient). The MEGD(H)EL syndrome is characterized by (3-methylglutaconic aciduria with deafness-dystonia, [hepatopathy], encephalopathy, and Leigh-like syndrome). Biochemical abnormalities: elevated urinary 3 – metilglutaconic and 3-metilglutaric acids, high lactate and alanine in serum. Diagnosis is confirmed when biallelic pathogenic variants in SERAC1 gene are found. Brain MRI: basal ganglia lesions and generalized atrophy.

Results/Case report:

A 30-year-old patient with a moderate intellectual disability, developed, since the age of 25, a progressive loss of previous capacities (hand dexterity, oral language), and later subacute generalized dystonic features. Currently he has spastic tetraparesis, dystonia, scoliosis and autistic behavior, with bilateral basal ganglia lesions on brain MRI. Genetic study revealed biallelic pathogenic variants in SERAC1 gene, confirm MEGD(H)EL. A 73 years old patient with cognitive impairment and progressive spastic tetraparesis had multiple periventricular T2 hyperintense lesions. She has a homozygotic SERAC1 variant NM_032861: exon4:c.T139A: p.F471 (rs112780453), considered benign. Biochemical study revealed elevated plasmatic alanine and urinary3-metilglutaconic and 3-metilglutaric acid. This profile is concordant with mitochondrial dysfunction and SERAC1 Deficit.

Conclusion:

The first patient has the clinical symptoms associated to the MEGD(H)EL syndrome, and the biochemical and genetic confirmation of the diagnosis, without reservations. However, in the second patient, the progressive paraparesis and cognitive impairment did not appear to be caused by multiple sclerosis nor subcortical vascular leukoencephalopathy (without vascular risk factors). The abnormal biochemical profile is suggestive of SERAC1 Deficiency, even without genetic confirmation. In what should we believe?
Anti-trypanosomatid Drugs/Candidates in Clinical Trials: What's New and What's Missing?
Authors: Fabris Marcieli , Maciel de Santiago-Silva Kaio , Henrique da Silva Lima Camilo , Ferreira Bispo Marcelle de Lima , Camargo Priscila Goes
Published: September 2023

Parasites and infectious agents are responsible for neglected tropical diseases (NTDs) that affect many countries worldwide. At least one NTD is found 149 countries, mostly in low-income countries with poor sanitation, and it impacts over a billion people. According to the World Health Organization, trypanosomiasis is a group of protozoan infections that cause Chagas disease (Trypanosoma cruzi), Human African Trypanosomiasis (sleeping sickness - Trypanosoma brucei rhodesiense or Trypanosoma brucei gambiense), and Leishmaniasis (Leishmania spp. - Trypanosomatidae family), which are all considered NTDs. It is estimated that approximately 500,000 deaths from NTD infections occur annually worldwide. Despite the many cases associated with NTDs, treatments for most of these diseases are available. However, they are associated with significant adverse effects and a growing number of drug-resistant microorganisms and require parenteral administration. Besides that, many trypanosomatid diseases are zoonotic, making eradication extremely difficult. In this way, despite scientific progress over the years, some drug discovery goals remain unmet, such as the development of new therapeutic classes, reduced toxicity, improved administration regimens, or the development of combination therapies. Therefore, this chapter intends to present the six categories of drugs, i.e., the currently used therapeutic agents, nitroaromatic compounds, azole antifungal, benzoxaboroles, nitrogen heterocycles, and miscellaneous agents in clinical trials for NTDs, focusing on infections caused by trypanosomatids. In addition, the review approach presents the development process of the new drugs or treatment regimens in Phase I, II, III, and IV studies of the clinical trials based on the Drugs for Neglected Diseases initiative (DNDi) portfolio published in December 2020.
Somatic Embryogenesis and Genetic Homogeneity Assessment in Coffea - Recent Approaches
Authors: Kumar Mishra Manoj , Kumar C. Huded Arun , Jingade Pavankumar
Published: September 2023

Coffee is one of the most preferred beverages consumed by millions of
people throughout the world. It is cultivated in more than 80 countries in tropical and
subtropical zones of Asia, Africa, and Latin America and provides livelihood to 125
million people worldwide. Among 125 coffee species known so far, only two coffee
species, Coffea arabica (arabica coffee) and Coffea canephora (robusta coffee), are
commercially cultivated for beverage production. Coffee is a perennial plant and
therefore subjected to constant environmental stress. However, during the last few
decades, sustainable coffee cultivation has been threatened by unprecedented climate
change. This calls for unified efforts, including cutting-edge research and modified
management practices. Although conventional breeding efforts have been developed to
address some issues, emerging biotechnology research, especially in-vitro propagation
technology, could augment the coffee cultivation landscape. Despite the tangible
progress made in coffee tissue culture, there were some grey areas, such as the level of
somaclonal variation and the genomic changes associated with somatic embryogenesis
in coffee, which needs to be addressed imminently. This chapter provides detailed
progress on coffee tissue culture and addresses some of the critical issues associated
with the genetic homogeneity of tissue culture plants.
Genetic Fidelity Assessment of Micropropagated Woody Plants Through Molecular Analysis
Authors: Özden Çiftçi Yelda , Kaya Ergun , Galatali Selin , Ekin Ozkaya Damla , Türkölmez Nil
Published: September 2023

Somaclonal variation is generally undesirable in woody plant tissue cultures
when the main aim is In Vitro micropropagation or transformation of selected material,
however, it could sometimes be useful for the production of new and valuable varieties.
Thus, the determination of somaclonal variation is very important for the genetic
fidelity of the micropropagated woody plant species. Molecular markers are generally
used in the identification of plant species, analysis of qualitative and quantitative trait
loci, determination of the genetic distance between genotypes, detection of stable, high
yielding and qualified varieties for variety registration and certification. Moreover,
molecular markers are also very useful for the evaluation of the genetic fidelity of
micropropagated cultures. Among many markers, ISSRs, SSRs, AFLPs and MSAPs
are found to be very efficient for the assessment of genetic stability of micropropagated
different woody plants since they are easy to apply, quick to use, and more reliable due
to their efficiency and repeatability. In this context, the aim of the present book chapter
is to review the advantages of molecular markers together with the summarization of
the studies on the determination of genetic stability of micropropagated woody species
using this technique in the last decade and causes of somaclonal variation.
GRUPOS VULNERÁVEIS E MINORIAS
Authors: Fardin de Vargas Eliziane , Hennig Leal Mônia Clarissa
Published: September 2023

o estudo pretende identificar se a Constituição Federal de 1988 e a jurisprudência do Supremo Tribunal Federal — quando trata do direito de igualdade e não discriminação — estabelecem uma distinção terminológica entre “minorias” e “grupos vulneráveis”, identificando quais grupos são enquadrados como minoritários e vulneráveis conforme a jurisprudência do mais alto tribunal brasileiro. Para tanto, utilizou-se do método de abordagem dedutivo e do método de procedimento analítico, objetivando, de início, elucidar a respeito da importância de uma nítida distinção terminológica entre “minorias” e “grupos vulneráveis”, a fim de prestar uma adequada proteção a esses grupos. Em seguida, analisar como se constrói e é incorporada na Constituição Federal de 1988 a noção de especial proteção de “grupos vulneráveis”, buscando identificar se em seu texto há uma distinção terminológica e metodológica entre “minorias” e “grupos vulneráveis”. E, por fim, pretendeu-se averiguar se é possível identificar nas construções jurisprudenciais do STF uma distinção terminológica entre os conceitos de “minorias” e “grupos vulneráveis”, bem como, a partir da análise jurisprudencial desenvolvida, identificar quais os grupos que o STF enquadra dentro de cada conceito.
EU E O DIREITO ADMINISTRATIVO
Authors: Monteiro Vera
Published: September 2023

O artigo é um depoimento pessoal sobre minha experiência como aluna, professora e espectadora do direito administrativo. Relato em primeira pessoa sobre as influências e o caminho profissional percorrido. Valorização do ambiente acadêmico colaborativo e inclusivo. Abordagem de manual não ajuda na solução de desafios contemporâneos envolvendo o direito administrativo.
A Rare Case of Isolated Infarcts of the Pons with Sudden Vertigo: Clinical Features and Imaging Findings
Authors: Kwon Dong Hwan , Jeon Eun kyung , Seo Young Joon
Published: September 2023

Isolated infarcts of the pons (IIP) are a rare subtype of ischemic stroke, accounting for less than 1% of all strokes. It refers to a specific type of ischemic stroke that occurs within the pons region of the brain. IIP can be associated with vertebrobasilar insufficiency in certain cases. This case report describes a 64-year-old female patient who presented with acute vertigo and spontaneous nystagmus to the lesion side, ultimately diagnosed with IIP in the posterior right side of pons. Tegmental pontine infarcts typically manifest as oblique small (lacunar) infarctions that are localized in the mediolateral tegmental area of the middle to upper pons. The patient’s symptoms resolved spontaneously, but a 2-mm infarct was confirmed by brain diffusion magnetic resonance imaging. This case highlights the distinctive symptoms associated with IIP and emphasizes the importance of careful neurological examination and advanced neuroimaging techniques for accurate diagnosis.
Developing Picture Storybook Learning Media in Terms of Students’ Critical and Creative Thinking Skills
Authors: Gunawan Gunawan , Suhardi Suhardi , Makawawa Junita Cristi
Published: September 2023

Students' critical and creative thinking skills are important in developing elementary school student's knowledge. However, many still found that elementary school students critical and creative thinking skills are still low. This condition is caused by learning that has not been able to facilitate the learning characteristics of elementary school students, especially in terms of the use of learning media in elementary schools. This study aims to develop picture storybook learning media regarding fifth-grade students' critical and creative thinking skills at SD Cluster IV Sintang. The method employed in this study was research and development of the Borg Gall model with ten stages consisting of: 1) research and information gathering, 2) planning, 3) initial product development, 4) initial field testing, 5) major product revision, 6) main product testing, 7) operational product revision, 8) operational field testing, 9) final product revision, and 10) dissemination and implementation. Data were collected utilizing interview techniques, expert validation, teacher and student response questionnaires, and critical and creative thinking skill test instruments. The results of this study indicate that the development of picture storybook learning media meets the aspects of quality, practicality, and product effectiveness in terms of the critical and creative thinking skills of fifth-grade elementary school students.
How to Improve the Performance of Public Elementary Schools? an Empirical Evidence from Indonesia
Authors: Kamaludin Kamaludin
Published: September 2023

This study aims to assess the construct validity of public elementary school performance from the proposed performance theory so that the observed variables can form a latent variable. This study used a quantitative approach with a measurement model in the form of First Order Confirmatory Factor Analysis. The sample in this study amounted to 233 principals of public elementary schools. Meanwhile, the location in this study is Brebes Regency, Central Java Province, Indonesia. Then, the data analysis in this research starts with developing the theoretical model, making a causality relationship path diagram, selecting the input matrix and obtaining the model estimate, assessing the identification of the structural model, and assessing the criteria of Goodness of Fit. This study reveals variables for measuring school performance, such as content standards, process standards, graduate competency standards, educator and education staff standards, facilities and infrastructure standards, management standards, financing standards, and education assessment standards, indicating that three observational variables are not significant and invalid in forming school performance latent variables, namely standards of educators and educational staff, standards of facilities and infrastructure, and standards of financing. In this regard, this research makes a practical contribution, namely that there is a need to change the orientation of fulfilling national education standards, which leads to school assessment based on performance appraisal based on curriculum development and implementation, teacher professional development, and optimizing the responsibility of stakeholders to improve educational quality so that schools able to provide optimal performance in providing services to the community.
Results of radiation therapy for invasive cervical cancer. Review of Russian literature
Authors:   Russian Scientific Center of Roentgenoradiology, Solodkiy V.A. , Panshin G.A. ,   Russian Scientific Center of Roentgenoradiology, Titova V.A. ,   Russian Scientific Center of Roentgenoradiology, Kondrashov A.A. ,   Russian Scientific Center of Roentgenoradiology
Published: September 2023

Over the past decades, the healthcare system in oncology has undergone significant changes associated with the introduction of information and digital technologies, new diagnostic and treatment algorithms based on visually controlled and fundamentally new technologies of surgical, radiation and drug treatment. These changes also affected socially significant oncological diseases, including cervical cancer (cervical cancer). However, it has not yet been completely possible to adequately solve the problem of diagnosing breast cancer within the 0-I stage of the disease and maintain the priorities of "monotherapy" (organ-preserving options for surgical or radiation treatment). At the same time, the treatment of locally advanced cervical cancer (International Federation of Gynecology and Obstetrics (FIGO) 2009/2018 – stages IB2-IVA/IB3-IVA) has not undergone major changes for almost 80 years and, at the same time, only radiation therapy was considered the standard of treatment for this spread of the tumor process. It should be emphasized that currently the development and implementation of increasingly expensive multicomponent treatment programs for such patients is ongoing, aimed, among other things, at achieving fairly satisfactory results, both in patients' survival and in their quality of life.
An Integrated Approach to ESP Teaching: A Case Study
Authors: KONE Kassoum
Published: September 2023

This article is about the relevance of the integrated approach in English for Specific Purposes (ESP) teaching. The purpose was to show the extent to which that teaching approach is essential in meeting ESP learners’ needs, as compared to a training based on grammar points and discrete items of the language. The study was grounded in the genre theory and it was made around main questions as follows: what is the appropriate approach to ESP teaching-learning? Should teaching ESP be about discrete items, grammar, or an integrated approach? What does the adoption of the integrated approach entail? To address these concerns, we conducted a research with the target population (6 learners from two different companies), through a semi-structured interview guide. The findings revealed that the integrated approach gives to ESP courses more meaning. The implementation of authentic activities is a means of giving the possibility to the students to build and acquire global knowledge in the language, which is far better than focusing on grammar points and isolated and floating terminologies.
A Fuzzy Robust Controller for Robotic Systems
Authors: Alnufaie Lafi
Published: September 2023

In this work a combination of type 2 fuzzy logic and nonsingular fast sliding mode technique is proposed to design a robust controller for a robotic system. Indeed, a nominal type 2 fuzzy model is used to contract the equivalent control signal. The switching signal is designed using adaptive type 2 fuzzy systems to overcome the knowledge of the upper bounds of uncertainties and external disturbances. Several simulation results are given to show the efficiency of the proposed approach.
Construcción de portafolios condicionales vs tradicionales: aplicación al Mercado Integrado Latinoamericano (MILA)
Authors: Sosa Castro Magnolia Miriam , Cabello Rosales Alejandra , Ortiz Calisto Edgar
Published: September 2023

El objetivo de este trabajo es construir portafolios, a partir del cálculo de parámetros no condicionales (tradicionales) y condicionales, estos últimos mediante modelos Generalizados Autoregresivos con Heteroscedasticidad Condicional (GARCH) univariados y de Correlación Condicional Dinámica (GARCH-DCC), bajo una distribución t-Student. Una vez realizada la estimación con ambos tipos de parámetros, se comparan los portafolios tradicionales con respecto a los condicionales, determinando cuál de ellos resulta en estimar una mejor relación riesgo-rendimiento. Para el diseño de los portafolios óptimos se emplean los índices bursátiles del Mercado Integrado Latinoamericano (MILA) constituido por Colombia, Chile, México y Perú, precios de cierre diarios de enero 2017 a junio 2022. Los resultados señalan que, los portafolios condicionales tienen mejor desempeño que los portafolios construidos de manera tradicional. Los hallazgos tienen importantes implicaciones en términos del desarrollo de estrategias de inversión internacional en mercados emergentes.
Implicaciones de la entrada en vigor de la RCEP en el comercio entre México, China y Estados Unidos: el caso del sector eléctrico
Authors: Liu Sun Xuedong , González García Juan
Published: September 2023

En este artículo, se analizan las perspectivas de la relación comercial entre México, China y Estados Unidos, ante la entrada en vigor de la Asociación Económica Regional Integral (RCEP) a partir de principios de 2022, lo que completa el nuevo marco del libre comercio global basado en la firma, instrumentación y puesta de operación de varios mega acuerdos regionales en el mundo como el TIPAT, el T-MEC, entre otros. Se plantea la hipótesis de que México podría ver fortalecido su intercambio comercial con Malasia y Vietnam, países que forman parte del TIPAT y de la RCEP simultáneamente, pero registraría potenciales pérdidas de competitividad en el mercado de Estados Unidos y una posible reducción en sus intercambios bilaterales con China. Para comprobar la hipótesis, se formula un modelo vector autorregresivo (VAR) para los productos pertenecientes al Capítulo 85 del sistema armonizado que México comercializó con Estados Unidos, China, Malasia y Vietnam entre 2010-2023.
Estructura económica y empleo en México: propuesta de análisis para políticas públicas
Authors: Arriaga Navarrete Rosalinda , Ramírez Cedillo Eduardo , González Pérez Claudia Rocío
Published: September 2023

Los niveles de empleo en una sociedad son un tema de suma importancia sobre los cuales se deberían de enfocar las políticas públicas. En la perspectiva del mercado laboral la literatura ha coincidido en que los mejores resultados se obtienen con un adecuado diseño de los programas, para lo cual es importante definir el objetivo que se quiere lograr y de forma adicional establecer un diagnóstico de la estructura económica y las interrelaciones que se dan entre subsectores y que abonan a la generación directa e indirecta de empleo. En este sentido, la presente investigación mediante el análisis de la Matriz Insumo-Producto ofrece evidencia de que los subsectores de la industria alimentaria, edificación, agricultura, preparación de alimentos y bebidas, equipo de transporte, construcción de obras de ingeniería civil, fabricación de prendas de vestir y cría y explotación de animales resultan ser los idóneos para proponer una política laboral dada su capacidad generadora de empleo.
Oferta laboral para el psicólogo recién egresado
Authors: García Reyes Mayra , Amador Velázquez Reyna
Published: September 2023

El presente trabajo tiene como objetivo describir las posibilidades de inserción al mercado laboral que poseen los egresados del programa educativo de la Licenciatura en Psicología, para ello se realizó una investigación documental, transversal, en la cual se revisaron sistemáticamente las ofertas laborales publicadas en los principales diarios del área centro de México y se consultó vía Internet bolsas de trabajo de las instituciones y empresas de la zona. También se tomó en cuenta a empresas transnacionales y empresas no transnacionales, estableciendo como requisito que ambas fueran del Estado de México. Los resultados derivados de la revisión evidencian que de las ofertas laborales, solo el .6 % corresponde a la profesión; en cuanto a las áreas más requeridas son educativa y laboral; las competencias en particular más solicitadas demandan experiencia laboral, las cuales no se poseen al ser recién egresado. Se puede concluir que el mercado laboral no permite al recién egresado de la Licenciatura en Psicología insertarse al trabajo remunerado por falta de pertinencia en el diseño curricular de su plan de estudios.
Los Estudios de Posgrado en México: propuesta para su Fortalecimiento e Impulso
Authors: Robledo Ramírez Erika , Delgado Coellar Alma Elisa , Márquez Villeda Huberta
Published: September 2023

El presente documento muestra un panorama general del posgrado en México, partiendo de una breve revisión de los antecedentes e instituciones con los que surge en nuestro país, ya que estos estudios, poslicenciatura, datan del siglo pasado por lo que son relativamente jóvenes. Asimismo, la reflexión se orienta a las principales políticas públicas que han imperado en el posgrado como la profesionalización docente, el otorgamiento de becas, el impulso a la investigación y la interinstitucionalidad de los programas. Según lo anterior y a partir de las necesidades que imperan derivadas de la incorporación de los modelos y modalidades educativas con tecnologías digitales en la educación, se sustenta el planteamiento de una serie de ejes orientados al fortalecimiento del posgrado.
Percepción del desempeño docente en alumnos regulares e irregulares
Authors: Cepeda Islas María Luisa , Alvarado Guerrero Irma Rosa , del Bosque Fuentes Ana Elena , Vega Valero Zaira , Rodríguez de la Rosa María Esther
Published: September 2023

El presente trabajo aborda la evaluación de la práctica docente a partir de la opinión de los alumnos en situación de rezago y regulares. El objetivo es identificar si existen diferencias entre la opinión de ambos tipos de alumnos, con miras a establecer acciones para mitigar el problema del rezago académico. Se utilizó un instrumento elaborado por el equipo de investigación. Incluye 63 reactivos y presenta cuatro opciones de respuesta a través de una escala tipo likert: siempre, frecuentemente, algunas veces y nunca. Las dimensiones a evaluar son: conocimiento del tema por parte del maestro, manejo de estrategias de aprendizaje que favorecen tanto el aprendizaje como la integración de los estudiantes y los sistemas de evaluación. Los resultados manifiestan algunas diferencias significativas entre las opiniones de los alumnos en situación de rezago y los regulares, en determinadas dimensiones, revelando que la calificación otorgada (aprobatoria o reprobatoria), influye en la percepción que se forman los alumnos del desempeño académico.
Enseñanza Remota de Emergencia: evaluación del aprendizaje en procesos educativos, en estudiantes universitarios
Authors: Flores Zepeda Margarita
Published: September 2023

La sindemia de Covid-19 provocó un cambio repentino a la enseñanza no presencial, que trascendió en la implementación de nuevas técnicas de enseñanza y evaluación. Bajo este contexto, el objetivo que se persigue es conocer el logro del aprendizaje alcanzado por los estudiantes universitarios usando la propuesta de “Aprendizaje-evaluación”, la cual hace uso de instrumentos de aprecio como exámenes en línea desarrollados en la plataforma DAEX; elaboración de proyectos y portafolio digital de evidencias como parte de la “Estrategia de cambio”, diseñada en apoyo al proceso educativo bajo la modalidad de Educación Remota de Emergencia, ERE, en cursos de corte metodológico en la Facultad de Estudios Superiores Cuautitlán, durante el año escolar 2021 y 2022.

Para el estudio se implementó una metodología con alcance descriptivo de naturaleza cuantitativa y diseño cuasi experimental, con cuatro grupos intactos y una población de 221 alumnos para la obtención de datos que permitan a los docentes conocer si, ¿el aprendizaje alcanzado por los estudiantes les permite acreditar el curso? mediante el uso de la propuesta de Aprendizaje-evaluación. El artículo concluye que la propuesta es apropiada para valorar el aprendizaje de los estudiantes que cursan asignaturas de corte metodológico.
High Performance VLSI Architecture for DC and Planar Modes of Intra Prediction in HEVC
Authors: B Sunil , M Vijaya Prakash A
Published: September 2023

Abstract: High Efficiency Video Coding (HEVC) achieves improved compression efficiency, but it introduces higher computational complexity due to intricate partitioning and increased angular modes in intra prediction. In this study, we propose a hardware architecture for handling the direct current (DC) and planar modes of intra prediction in the HEVC standard. To evaluate our proposed architecture, we performed synthesis using both TSMC 180nm and TSMC 90nm technologies. We later conducted physical implementation using Physical Cell 90nm technology. The results show significant improvements when moving from TSMC 180nm to TSMC 90nm technology, with the chip area reducing by approximately three times and power consumption decreasing by over six times. After completing the physical layout phase, we obtained a chip area of 112.19 mm2 and a power consumption of 3.88 mW. Comparing the synthesis results with the physical design phase, we observed a slight increase in chip area by around 1.5 times, while the power consumption decreased by approximately 0.4 times. The proposed architecture achieves a throughput of 27 pixels per clock cycle and supports a block size of 16x16, with the potential for further extension
ALÉM DAS EXPLICAÇÕES CAUSAIS: a compreensão do suicídio na perspectiva da psicologia fenomenológica existencial
Authors: Rosa Roberta da Rocha , Mallmann Loivo José , Sales Amanda Kelly Charato , Bernardes Andressa Bretas , Momose Danielle Miyuki , Silva Mariana Andrade , Coriolano Viviane Taís
Published: September 2023

This article is about suicide on the Phenomenological Existential Psychology perspective. The question that guides this study is: how does the Phenomenological Existential Psychology understands and analyses the suicide subject? The general goal of the article is to discuss the matter of the suicide under the heideggerian Phenomenological Existential Psychology’s view. The specific goals are: contextualize the suicide matter; to understand the finitude, death and autonomy categories; and analyse the discussion of moralization, blaming and pathologizing of the suicide. This is a narrative literature review that attempts to describe the development of such theme, through the analysis of scientific production. Starting with a statistical analysis and the different ways of understanding of the suicide, this article attempted to reach a deeper reflection about the existential matters about the phenomenon. Going through reflections about the meaning of finitude, using some ideas, such as anguish, freedom and choice, and also aspects involving matters of cause and motive. Lastly, we attempted to deepen the interpretations of traditional labelers that that remains about the ways of understanding the behavior of putting an end to one’s own life. With an emphasis for the moralizing view, of blaming and pathologizing. We hope that the discussions made can favor a point of view that encompasses the subjectivity and complexity of each existence regarding suicide.
The rights and obligations of leasers-farmers in Attica of the second half of the IV century BC. according to the lease agreements of sacred lands
Authors: Bulycheva Elena Vladimirovna
Published: September 2023

The purpose of the study is to reconstruct the range of rights and obligations of farmers-tenants of sacred lands (temenos) in Attica in the second half of the 4th century BC on the basis of epigraphic material. In modern historiography, there are no special works devoted to this problem. At the same time, the study of the legal status of the tenant farmer is of great importance for understanding the nature of land relations in Attica in the 4th century BC. Having studied the temenos lease agreements, the author characterized the legal status of tenant farmers, considering in detail their rights and obligations. The author’s conclusions: in accordance with the terms of the lease agreement, the tenant farmers personally cultivated the sacred lands, while their rights and obligations were clearly fixed in the temenos lease agreements.
The duel between Marius and the Celtiberian: a new reading
Authors: Merkulov Ivan Vasilievich
Published: September 2023

The duel of Gaius Marius with a Celtiber is one of the heroic episodes of the early biography of the future seven-time consul and commander. Plutarch’s information about this duel is fragmentary and does not allow us to fully clarify the circumstances under which it took place. In part, they are clarified by the archaeological data obtained by A. Schulten during excavations in the area of ancient Numantia. After analyzing the sources and literature, the author came to the conclusion that the episode with the duel became for Marius the starting point in his military career, from which his rise began. According to the author, in fact, the notorious duel could have been an ordinary skirmish, but later Marian propaganda turned it into a heroic deed of Marius, a brilliant military leader and an experienced «father commander». The author does not exclude the possibility that Plutarch himself became the culprit of the confusion, who did not distinguish between an individual duel and participation in a collective hand-to-hand combat.
Hamiltonian simulation in the Pauli basis of multi-qubit clusters for condensed matter physics
Authors: André Eduardo L. , Tsirulev Alexander N.
Published: September 2023

We propose an efficient method for Hamiltonian simulation of multi-qubit quantum systems with special types of interaction. In our approach, the Hamiltonian of a \(n\)-qubit system should be represented as a linear combination of the standard Pauli basis operators, and then decomposed into a sum of partial Hamiltonians, which are, in general, not Pauli operators and satisfy some anticommutation relations. For three types of Hamiltonians, which are invariant with respect to permutations of qubits, the effectiveness of the main algorithm in the three-qubit cluster model is shown by calculating the operator exponentials for these Hamiltonians in an explicit analytical form. We also calculate the density operator, partition function, entropy, and free energy of the cluster weakly coupled to a thermal environment. In our model, the cluster is in the Gibbs state in the temperature interval \(0.1\!-\!2\:\!\text{K}\), which corresponds to the operating range of modern quantum processors. It follows from our analysis that the thermodynamic properties of such systems strongly depend on the type of internal interaction of qubits in the cluster.
“Employee of the Transcaucasus Mission.” Publication of the Diocesan Church Brotherhood of the Holy Faithful Prince Alexander Nevsky in Sukhum. Index of Articles
Authors:   Autonomous Non-profit Organisation “Book Club of the Writers’ Union”, Sterlikova Sofiyanina A.
Published: September 2023

The index of articles published on the pages of the journal “Employee of the Transcaucasian Mission” — a publication of the Diocesan Church Brotherhood of the Holy Right-Believing Prince Alexander Nevsky in the city of Sukhum, contains a page-by-page list of publications published in 93 issues, from January 1, 1912 to August 1916. The value of the presented material lies in its reference and bibliographic nature. The index gives an idea of a wide range of problems and topics of publications, the relevance of the tasks of the Sukhumi diocese, and the proposed ways to solve them. Among the frequently discussed issues are the religious and moral needs of the population of the Sukhum diocese, opposition to the influence of Mohammedanism and the spread of sects, the organization of pastoral and parochial schools. The circle of authors of the “Cooperate ...” were clergymen, historians, ethnographers, writers who stood at the origins of the Abkhaz enlightenment: Bishop Andrei (Ukhtomsky) of Sukhumi, the founder of the Abkhaz written literature D.I. Gulia, local historian and teacher K.D. Machavariani, local historian-ethnographer A.I. Chukbar, educator Art. A. Alferov and others.
Translation as an Important Factor of Interliterary and Intercultural Dialogue (From the History of Translation Activities in Abkhazia and Russia: Russian-Abkhaz and Abkhaz-Russian Segments)
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Biguaa Vyacheslav A.
Published: September 2023

The article examines the history of the Russian-Abkhaz and Abkhaz-Russian segments of literary translation, theoretical problems of translation. The history of the formation of the Russian translation school and thought is reflected. Literary translation is seen as an essential element of intercultural and interliterary dialogue. The presented material indicates that at the initial stage of the formation of Abkhaz literature, like Russian and many other literatures, translation occupied a special place, often the very history of national literature began with translation. The first translations from Russian into the Abkhaz language were mainly associated with spiritual Christian literature. The first period in the history of translation in Abkhazia (1860s — early 1920s) is educational in nature. The history of the Abkhaz-Russian and Russian-Abkhaz artistic translation of the Soviet period is highlighted. At this time, many works of Russian writers sounded in the Abkhaz language For the Abkhaz creative intelligentsia, the Russian language has become a bridge that provides access to world literature. Foreign classics were also translated through Russian translations. A huge number of works by Abkhaz writers have been translated from Abkhaz into Russian. The flourishing of the Russian translation school is noted. The article highlights promising directions in the study of literary translation.
Translation — Recovery Tool of the Common Cultural Space
Authors:   Abkhazian Institute for Humanities Research named after D.I. Gulia under the Academy of Sciences of Abkhazia, Zantaria Vladimir K.
Published: September 2023

The publication is devoted to the unique experience of translating Russian classics into the Abkhazian language, and summarizes the results of painstaking work in this subtlest area of artistic creativity. Outstanding translations of Russian poetry are proposed, which organically entered the culture of Abkhazia and reflected the spirit, philosophy and symbolism of Russian culture. The poetic anthology of Russian classics in the Abkhaz language is represented by A.S. Pushkin’s poems “Arion,” “I am here, Inezilya ...,” “If life deceives you ...,” M.Yu. Lermontov’s “Prisoner,” “I look at the future with fear ...,” “Ballad (A beautiful maiden sits over the sea ...),” A.A. Fet’s “Your cheeks are burning ...,” “Do not wake her at dawn ...,” F.I. Tyutchev’s “Insomnia,” “And there is no feeling in your eyes ...,” “Probleme (Problem),” “The Last Cataclysm,” N.S. Gumilyov’s “By the Fireplace,” “Eagle,” A.A. Blok’s “The Girl Sang in the Church Choir,” “To Friends,” V.Ya. Bryusov’s “Assargadon,” “Do not cry and do not think...,” A.A. Akhmatova’s “I am not with those who left the earth...,” “And now you are heavy and dull...,” “Tearful autumn, like a widow …,” “I had a voice,” V.F. Khodasevich’s “From weak eyelids driving a vague dream…,” “By grain.”
Philological Analysis of Artistic Text as a Means of Understanding Spiritual Power and Beauty of the Russian Word (Subject-Didactic Aspects)
Authors: Bobylev Boris G.
Published: September 2023

The article is devoted to the subject-didactic concept of the academic discipline “Philological Analysis of a Literary Text” (FAKHT) in the system of professional training of Russian language teachers for a international school. The methodological basis of the concept is the linguodidactic tradition laid down in the works of Academician of the Russian Academy of Education N.M. Shansky: taking into account the various features of the mastering Russian verbal culture by speakers of other languages. The modern linguistic and educational situation in the Republic of Abkhazia, as well as other Russian-speaking enclaves of the post-Soviet space, is characterized. It is indicated that Russian classical literature is the highest and most perfect embodiment of the national linguistic personality. It is noted that the preservation and revival of the Russian world involves bringing this fact to a clear understanding of the people, as well as revealing all the spiritual power and all-humanity of the classical literature of Russia. It is emphasized that one of the main methodological foundations of the FAKHT course is the optimal combination of emotional-intuitive and rational-logical aspects of perception and understanding of a literary work. The article characterizes the three-level methodology of the FAKHT in an international audience. The explanatory power of this technique is revealed, which helps to expand the boundaries of understanding the meaning inherent in the text. The connection of the proposed technique of analysis and understanding of a literary text with the psycholinguistic theory of N.I. Zhinkin is shown, which reveals the mechanisms of mastering the code by the learners, which objectifies the meaning inherent in the literary text. At the same time, understanding is considered not only as the perception of the literary idea as a whole, but also as a stage of spiritual growth. The article presents a variant of the FAKHT course program, aimed at the Abkhazian audience.
Philosophical Lyrics of Bagrat Shinkuba in Russian Translation
Authors:   Abkhazian Institute for Humanities Research named after D.I. Gulia under the Academy of Sciences of Abkhazia, Zantaria Vladimir K.
Published: September 2023

The article analyzes the experience of translating the philosophical lyrics of the outstanding Abkhaz poet Bagrat Shinkuba into Russian as an example of high professionalism in such a refined and delicate area. Considered as the most successful transcriptions of the lyrical works of the Abkhaz master, translations of the poems “My Star” (S. Lipkin), “They drink for my long life!” (K. Simonov), “This inevitable hour will come ...” (D. Chachkhalia), “The hearth burns and the flame curls” (Y. Kozlovsky), “The word has a soul” (L. Ozerov). It is noted that translators turned to classical principles and stylistic devices, which made it possible to convey the structure of the poetic fabric of the original, a synthetic fusion of elements of the folklore and mythological worldview of the “elements of folk thinking” and the poet’s lyrical self-expression. It is shown how in translations, while maintaining mainly the stylistic constructions of the original, a kind of Russian artistic model of the Abkhazian classical verse is created. It is emphasized that the translation of the lyrics of Bagrat Shinkuba into Russian is an important and responsible artistic task.
Pages of History in B.V. Shinkub’s Novel “The Last of the Departed”
Authors:   Institute of Oriental Studies of the Russian Academy of Sciences, Tsvizhba Larisa I.
Published: September 2023

The historical novel by B.V. Shinkuba “The Last of the Departed” is based on the confession of the hundred-year-old Zaurkan Zolak, the last of the Ubykhs, who lived out his days in one of the Turkish villages. The novel conveys documented military clashes between the Russian army and the peoples of the Caucasus in the 19th century. Comparison of individual scenes of the novel and archival documents makes it possible to identify the coincidence of artistic descriptions of the tragic history of the Ubykhs with real events: their place of residence, lifestyle, raids, including on Abkhazia, disagreements in Ubykh society on the issue of attitude towards Russia, the role of the main Ubykh surname Berzek, to which Hadji Berzek and his nephew belong. Both in the novel and in archival documents, much attention is paid to the ruler of Abkhazia, Mikhail Shervashidze, who acted as an intermediary between the Ubykhs and Russian generals. Solving the key question for themselves: to submit and stay to live where the Russian generals indicate, or to move to Turkey, the Ubykhs chose resettlement, which entailed their complete disappearance. The identified historical sources confirm the authenticity of the events described in B. Shinkuba’s novel “The Last of the Departed.”