bluuebunny/crossref_metadata_2025 huggingface dataset:
Inflammatory Markers Associated With Diabetes Mellitus – Old and New Players
Authors: Muzurović Emir , Stanković Zoja , Kovačević Zlata , Škrijelj Benida Š. , Mikhailidis Dimitri P.
Published: November 2020

Diabetes mellitus (DM) is a chronic and complex metabolic disorder, and also an important cause of
cardiovascular (CV) diseases (CVDs). Subclinical inflammation, observed in patients with type 2 DM (T2DM),
cannot be considered the sole or primary cause of T2DM in the absence of classical risk factors, but it represents
an important mechanism that serves as a bridge between primary causes of T2DM and its manifestation.
Progress has been made in the identification of effective strategies to prevent or delay the onset of T2DM. It is
important to identify those at increased risk for DM by using specific biomarkers. Inflammatory markers correlate
with insulin resistance (IR) and glycoregulation in patients with DM. Also, several inflammatory markers
have been shown to be useful in assessing the risk of developing DM and its complications. However, the intertwining
of pathophysiological processes and the not-quite-specificity of inflammatory markers for certain clinical
entities limits their practical use. In this review we consider the advantages and disadvantages of various inflammatory
biomarkers of DM that have been investigated to date as well as possible future directions. Key features
of such biomarkers should be high specificity, non-invasiveness and cost-effectiveness.
Application of Machine Learning Techniques in Drug-target Interactions Prediction
Authors: Zhang Shengli , Wang Jiesheng , Lin Zhenhui , Liang Yunyun
Published: November 2020

Background:

Drug-Target interactions are vital for drug design and drug repositioning. However,
traditional lab experiments are both expensive and time-consuming. Various computational methods which applied
machine learning techniques performed efficiently and effectively in the field.

Results:

The machine learning methods can be divided into three categories basically: Supervised methods,
Semi-Supervised methods and Unsupervised methods. We reviewed recent representative methods applying
machine learning techniques of each category in DTIs and summarized a brief list of databases frequently used
in drug discovery. In addition, we compared the advantages and limitations of these methods in each category.

Conclusion:

Every prediction model has both strengths and weaknesses and should be adopted in proper ways.
Three major problems in DTIs prediction including the lack of nonreactive drug-target pairs data sets, over optimistic
results due to the biases and the exploiting of regression models on DTIs prediction should be seriously
considered.
Quantitative Proteomic Study of Peripheral Blood Monocytes Identified Novel Genes Involved in Osteoporosis
Authors: Xu Qing , Xu Li , He Pei , Sun Yang-Hua , Lu Xin , Lei Shu-Feng , Deng Fei-Yan
Published: November 2020

Objective:

Osteoporosis (OP) is mainly characterized by low Bone Mineral Density (BMD)
and microarchitectural deterioration of bone tissue. We performed label-free quantitative proteomics
to discover novel proteins involved in the pathogenesis of osteoporosis.

Methods:

We employed an extreme sampling study design to collect subjects with low BMD (Z-score<-
1.30±0.47) and high BMD (Z-score>1.06±0.49). Liquid Chromatography and Mass Spectrometry
(LC-MS) technologies were used to identify Peripheral Blood Monocyte (PBM)-expressed
proteins significant for OP in Chinese elderly women (Study Sample 1) and men (Study
Sample 2), respectively.

Results:

A total of 131 Differentially Expressed Proteins (DEPs) and 200 DEPs were identified in
subjects with low vs. high BMD from the study samples 1 and 2, respectively. Interestingly, three
DEPs (WNK1, SHTN1, and DPM1) were significantly and consistently regulated with BMD in
both genders. GO analysis showed that these DEPs were significantly enriched in “extracellular exosome”,
“protein binding” and “cell-cell adherens junction” (p<0.05). Pathway enrichment results
showed that these DEPs were significantly enriched in “protein ubiquitination”, “ER-Phagosome
pathway” and “antigen processing” (p<0.05). Protein-Protein Interaction (PPI) networks were constructed,
pointing out key node proteins, including HSPA8, PKM, AKT1, and ABI1. Mining data
from independent -omics studies highlighted that 174 DEPs, as identified from above, were significant
for OP in Caucasians as well, including WNK1 and DPM1.

Conclusion:

The study identified known and novel proteins significant for OP in both genders
and/or across ethnicities in both Chinese and Caucasians. Our findings may provide clues for further
research on the underlying pathogenic mechanism of OP.
Iatrogenic Right Atrial Thrombus Complicated by Pulmonary Embolism: Management and Outcomes
Authors: Battisha Ayman , Madoukh Bader , Sawalha Khalid , Patel Brijesh
Published: November 2020

Right atrial thrombus can originate from distal venous sources or can be iatrogenic, secondary
to the placement of central venous catheters, atrial devices, or surgeries. One of the most
common complications of Central Venous Catheters (CVCs) is thromboembolism, which can be either
fixed to the right atrium or can be free-floating. Device-related Right Atrial Thrombosis
(RAT) can result in catheter occlusion, vascular occlusion, infection, and pulmonary embolism.
The true incidence of these complications is unknown because the diagnosis may not be considered
in asymptomatic patients, and it might be missed by Transthoracic Echocardiography (TTE). In
this literature review, we discuss iatrogenic etiologies of RAT that is complicated by pulmonary
embolism. We highlight the importance of maintaining a high index of suspicion of iatrogenic
RAT, possible complications, and its management.
Trends and Applications of Brain Computer Interfaces
Authors: Veer Karan , Yadav Drishti , Yadav Shilpee
Published: November 2020

This article provides a comprehensive review of the recent trends and applications of
BCIs. This review also provides future directions towards the acceleration and maturation of BCI
technology. Based on a methodical search strategy, major technical databases were searched in quest
of research papers of average and outstanding interest. A total of 188 research works were included
within this review due to their suitability and state-of-the-art achievements. This review identifies
various eminent applications of BCIs in medical and non-medical domains. The findings of this review
reveal the need for further exploration of BCI devices outside the laboratory-based settings for
their development and seamless integration. In addition, applications of BCIs, including neuromarketing,
neurorehabilitation, and neuroergonomics, require additional investigations for further validation
and fruition of BCI technology. Based on this review, it is concluded that BCIs are in their
embryonic stage and seek further research and investigation for their maturation.
Synthesis, Aromatase Inhibitory, Antiproliferative and Molecular Modeling Studies of Functionally Diverse D-Ring Pregnenolone Pyrazoles
Authors: Banday Abid H. , Saeed Bahjat A. , Al-Masoudi Najim A.
Published: November 2020

Background:

Aromatase, a cytochrome P450 hemoprotein that is responsible for estrogen
biosynthesis by conversion of androgens into estrogens, has been an attractive target in the treatment of hormonedependent
breast cancer. Design of new steroidal aromatase inhibitors becomes imperative.

Objective:

Synthesis and biological evaluation of two classes of structurally and functionally diverse D-ring pregnenolone pyrazoles as type I aromatase inhibitors and antiproliferative agents.

Methods:

Pregnenolone (1) was converted to 3β-hydroxy-21-hydroxymethylidenepregn-5-en-20-one (2), which
upon cyclization with phenylhydrazine generated regioisomeric pairs of pyrazoles 4 and 5. Further, Knoevenagel
condensation of pregnenolone (1) with 3-oxo-3-phenylpropanenitrile (6) produced 2-benzoyl-3-(3b-hydroxyandrostan-
5-ene-20-ylidene)-but-2-enenitrile (7), which upon cyclization with hydrazine or phenylhydrazine
generated the pyrazoles 8 and 9. All new steroidal derivatives were tested for their aromatase inhibition activity
using Dibenzylfluorescein (DBF) based fluorescence assay developed by Stresser et al. Antiproliferative
activities were measured using Sulforhodamine B assay. The activities were promising and there was a coherence
between aromatase inhibitory and antiproliferative activities.

Results:

The study reveals the immense potential of pregnenolone pyrazoles as aromatase inhibitors for the
treatment of breast cancer. Molecular docking studies proved efficient binding of the new steroidal analogs on
human placental aromatase.

Conclusions:

n the overall study, most of the compounds exhibited potential activity for the treatment of
hormone dependent breast cancer. Compounds 4c and 4d were found to be the most promising pharmacons.
Furthermore, compounds 4c and 4d were applied for their molecular docking study on human placental
aromatase to predict their possible binding modes with the enzyme. These studies revealed that such molecules
have high scope and potential for further investigation towards the treatment of estrogen dependent breast cancer.
Research Status of Subsequent Machining of Laser Cladding Layers
Authors: Li Lei , Cai Yujun , Li Guohe , Liu Meng
Published: November 2020

Background:

As an important method of remanufacturing, laser cladding can be used to obtain the parts with
specific shapes by stacking materials layer by layer. The formation mechanism of laser cladding determines the “Staircase
effect”, which makes the surface quality can hardly meet the dimensional accuracy of the parts. Therefore, the subsequent
machining must be performed to improve the dimensional accuracy and surface quality of cladding parts.

Methods:

In this paper, chip formation, cutting force, cutting temperature, tool wear, surface quality, and optimization of
cutting parameters in the subsequent cutting of laser cladding layer are analyzed. Scholars have expounded and studied
these five aspects but the cutting mechanism of laser cladding need further research.

Results:

The characteristics of cladding layer are similar to that of difficult to machine materials, and the change of
parameters has a significant impact on the cutting performance.

Conclusion:

The research status of subsequent machining of cladding layers is summarized, mainly from the aspects of
chip formation, cutting force, cutting temperature, tool wear, surface quality, and cutting parameters optimization. Besides,
the existing problems and further developments of subsequent machining of cladding layers are pointed out. The efforts are
helpful to promote the development and application of laser cladding remanufacturing technology.
The Polymorphism of miR-146a (rs2910164) and Breast Cancer Risk: A Meta-Analysis of 17 Studies
Authors: Moossavi Maryam , Shojaee Maryam , Musavi Mahsa , Ibrahimi Reza , Ibrahimi Mostafa , Khorasani Milad
Published: November 2020

Background:

Single-Nucleotide Polymorphisms (SNPs) in genes responsible for coding
microRNAs (miRNAs) are shown to be crucial in progression of Breast Cancer (BC).

Objective:

The purpose of this meta-analysis is to obtain more definitive and reliable results due to the
ambiguity and inconsistency of the previous findings in this regard. This study aimed at clarifying the
association of mir14a polymorphisms with breast cancer.

Methods:

We searched PubMed, EMBASE, Web of Science and Google Scholar databases for papers
published before August 10, 2019. Afterward, genotypes’ distribution, genotyping methods and ethnicity
groups were extracted and Overall analyses were conducted. A total number of seventeen researches
on 7676 subjects and 7476 controls were found to meet our criteria in this meta-analysis.

Results:

Our observations confirmed the increased risk in breast cancer with rs 2910164 polymorphism
in three genetic models: allele contrast fixed genetic model, Recessive fixed genetic model and
CC vs. GG genetic model (P value 0.0109, 0.0404 and 0.0019, respectively).

Conclusion:

The rs2910164 polymorphism is associated with increased breast cancer risk. We suggest
that more multicenter studies with larger samples investigate this matter to further clarify the association
and verify our findings.
MEMBANGUN KARAKTER GENERASI MUDA MELALUI NILAI RITUAL METRI
Authors:   IAIN Tulungagung, Mulyaningtyas Rahmawati , Arinugroho Yogi Dian ,   SMK Negeri 4 Malang
Published: November 2020

The salvation ritual or it is so called metri in Ringinpitu Village still exists and goes on. The values contained in the ritual of metri can be used as a means to build the worthy character of the youth generation. This study uses descriptive qualitative method. Data were obtained from the results of interviews and literature review. Interviews were conducted with the elders of Ringinagung Subvillage, Ringinpitu Village, , Tulungagung Regency. The results of this study reveal that there are philosophical and religious values in ritual of metri in Ringinpitu Village. These values are contained in the ijab (speech / prayer of the leader of metri ritual) and the special dishes prepared. Worthy characters that can be built from metri rituals are mutual cooperation, cooperation, harmony, always remembering God, and always remembering the merits of the predecessors or ancestors.
Variations in Secondary Health Resource Utilization Post Clozapine Initiation
Authors:   Cumbria, Northumberland, Tyne and Wear NHS Foundation Trust, Monkwearmouth Hospital, Newcastle Road, Sunderland SR1 , UK, de Silva Prasanna N.
Published: November 2020

This study looked at secondary care utilization metrics as an effectiveness indicator of Clozapine initiation in 77 patients over the following year compared to the year prior to initiation. It was found that there was a marginal drop in psychiatric bed utilization, alongside reduced crisis team use. Medical and psychiatric outpatient use increased, as did physical health interventions. Overall, compared with costs over the year preceding Clozapine initiation, an estimated saving per patient of £3,867 ($5,065) was achieved.
Smartphone-Based Monitoring of Parkinson Disease: Quasi-Experimental Study to Quantify Hand Tremor Severity and Medication Effectiveness (Preprint)
Authors: Kuosmanen Elina , Wolling Florian , Vega Julio , Kan Valerii , Nishiyama Yuuki , Harper Simon , Van Laerhoven Kristof , Hosio Simo , Ferreira Denzil
Published: November 2020

BACKGROUND

Hand tremor typically has a negative impact on a person’s ability to complete many common daily activities. Previous research has investigated how to quantify hand tremor with smartphones and wearable sensors, mainly under controlled data collection conditions. Solutions for daily real-life settings remain largely underexplored.

OBJECTIVE

Our objective was to monitor and assess hand tremor severity in patients with Parkinson disease (PD), and to better understand the effects of PD medications in a naturalistic environment.

METHODS

Using the Welch method, we generated periodograms of accelerometer data and computed signal features to compare patients with varying degrees of PD symptoms.

RESULTS

We introduced and empirically evaluated the tremor intensity parameter (TIP), an accelerometer-based metric to quantify hand tremor severity in PD using smartphones. There was a statistically significant correlation between the TIP and self-assessed Unified Parkinson Disease Rating Scale (UPDRS) II tremor scores (Kendall rank correlation test: z=30.521, P<.001, τ=0.5367379; n=11). An analysis of the “before” and “after” medication intake conditions identified a significant difference in accelerometer signal characteristics among participants with different levels of rigidity and bradykinesia (Wilcoxon rank sum test, P<.05).

CONCLUSIONS

Our work demonstrates the potential use of smartphone inertial sensors as a systematic symptom severity assessment mechanism to monitor PD symptoms and to assess medication effectiveness remotely. Our smartphone-based monitoring app may also be relevant for other conditions where hand tremor is a prevalent symptom.
Zero-Effort Ambient Heart Rate Monitoring Using Ballistocardiography Detected Through a Seat Cushion: Prototype Development and Preliminary Study (Preprint)
Authors: Malik Ahmed Raza , Boger Jennifer
Published: November 2020

BACKGROUND

Cardiovascular diseases are a leading cause of death worldwide and result in significant economic costs to health care systems. The prevalence of cardiovascular conditions that require monitoring is expected to increase as the average age of the global population continues to rise. Although an accurate cardiac assessment can be performed at medical centers, frequent visits for assessment are not feasible for most people, especially those with limited mobility. Monitoring of vital signs at home is becoming an increasingly desirable, accessible, and practical alternative. As wearable devices are not the ideal solution for everyone, it is necessary to develop parallel and complementary approaches.

OBJECTIVE

This research aims to develop a zero-effort, unobtrusive, cost-effective, and portable option for home-based ambient heart rate monitoring.

METHODS

The prototype seat cushion uses load cells to acquire a user’s ballistocardiogram (BCG). The analog signal from the load cells is amplified and filtered by a signal-conditioning circuit before being digitally recorded. A pilot study with 20 participants was conducted to analyze the prototype’s ability to capture the BCG during five real-world tasks: sitting still, watching a video on a computer screen, reading, using a computer, and having a conversation. A novel algorithm based on the continuous wavelet transform was developed to extract the heart rate by detecting the largest amplitude values (J-peaks) in the BCG signal.

RESULTS

The pilot study data showed that the BCG signals from all five tasks had sufficiently large portions to extract heart rate. The continuous wavelet transform–based algorithm for J-peak detection demonstrated an overall accuracy of 91.4% compared with electrocardiography. Excluding three outliers that had significantly noisy BCG data, the algorithm achieved 94.6% accuracy, which was aligned with that of wearable devices.

CONCLUSIONS

This study suggests that BCG acquired through a seat cushion is a viable alternative to wearable technologies. The prototype seat cushion presented in this study is an example of a relatively accessible, affordable, portable, and unobtrusive zero-effort approach to achieve frequent home-based ambient heart rate monitoring.

CLINICALTRIAL
Deriving Key Architectural Features of FHIR-BlockChain Integration through the Qualitative Content Analysis (Preprint)
Authors: Lee Jaehoon , Park Yu Rang , Beck Sang Sook
Published: November 2020

BACKGROUND

The blockchain has been highlighted its possibility as a technology to ensure immutability, transparency, and decentralization of data in information systems in various industries. Amongst the possibility of blockchain in the healthcare industry, one of the informatics areas that leverage the benefits of using blockchain in healthcare information exchange while it is combined with the use of fast healthcare interoperability resources (FHIR).

OBJECTIVE

To investigate the key architectural features of FHIR and blockchain integration that provides the benefits of the immutability of transaction data for a decentralized and secured healthcare information exchange framework.

METHODS

We conducted an in-depth, individual, semi-structured interview with four domain knowledge experts in the area of FHIR and medical blockchain. Our interview plan were qualified by the COREQ criteria (Consolidated Criteria for Reporting Qualitative Research), which is an analysis method for the qualitative content analysis. We conducted the interview based on seven key questions and additional open discussion of technical, business, and legal aspects of the FHIR-blockchain architectures. The results of the interviews were recorded, summarized, and codified in a structured way.

RESULTS

As a result of the interview, we characterized 1) the types of on-chain information from FHIR transactions to be stored inside blocks and 2) the features of FHIR - blockchain architectures and their possible use case scenarios. In addition to the characterization of the architectures, we discussed the topics; 1) potential legal issues and 2) justification of using blockchain in healthcare information exchange, and 3) practical implications and guidelines of the architectures for implementation.

CONCLUSIONS

Although FHIR-blockchain integration has been considered as a promising tool for decentralized and secured healthcare information exchange, it should be clarified as to how it aligned with business requirements. A detailed and/or tailored guidelines of implementation in the architectural, functional, and legal perspectives may need to be demonstrated by the benefits of using FHIR-blockchain integration.
Esaxerenone (CS-3150) in Patients with Type 2 Diabetes and Microalbuminuria (ESAX-DN)
Authors: Ito Sadayoshi , Kashihara Naoki , Shikata Kenichi , Nangaku Masaomi , Wada Takashi , Okuda Yasuyuki , Sawanobori Tomoko
Published: November 2020

Background and objectives

Diabetic kidney disease is an important complication of type 2 diabetes. In a phase 2b study, adding esaxerenone to renin-angiotensin system inhibitors dose dependently reduced the urinary albumin-to-creatinine ratio in patients with type 2 diabetes and microalbuminuria. This 52-week phase 3 study further investigated the effects of esaxerenone on the urinary albumin-to-creatinine ratio in this patient group.

Design, setting, participants, & measurements

In this multicenter, randomized, double-blind study, patients with type 2 diabetes and a urinary albumin-to-creatinine ratio of 45 to <300 mg/g creatinine treated with renin-angiotensin system inhibitors were randomized to esaxerenone or placebo for 52 weeks (n=455). Esaxerenone was initiated at 1.25 mg/d and titrated to 2.5 mg/d on the basis of serum potassium monitoring. The primary endpoint was the proportion of patients achieving urinary albumin-to-creatinine ratio remission (<30 mg/g creatinine and ≥30% reduction from baseline on two consecutive occasions).

Results

Overall, 49 (22%) and nine (4%) patients in the esaxerenone and placebo groups, respectively, achieved urinary albumin-to-creatinine ratio remission (absolute difference 18%; 95% confidence interval, 12% to 25%; P<0.001). The percent change in urinary albumin-to-creatinine ratio from baseline to end of treatment was significantly higher with esaxerenone versus placebo (−58% versus 8%; geometric least-squares mean ratio to placebo 0.38, 95% confidence interval, 0.33 to 0.44). There was a significant improvement with esaxerenone versus placebo in time to first remission (hazard ratio, 5.13; 95% confidence interval, 3.27 to 8.04) and time to first transition to urinary albumin-to-creatinine ratio ≥300 mg/g creatinine (hazard ratio, 0.23; 95% confidence interval, 0.11 to 0.48). More patients had a serum potassium level ≥6.0 or ≥5.5 mEq/L on two consecutive measurements in the esaxerenone group (20 [9%]) versus placebo (5 [2%]); these events were asymptomatic and resolved after dosage reduction or treatment discontinuation.

Conclusions

Adding esaxerenone to existing renin-angiotensin system inhibitor therapy in patients with type 2 diabetes and microalbuminuria increased the likelihood of albuminuria returning to normal levels, and reduced progression of albuminuria to higher levels.
Typology of Stakeholders in Perspective of Sustainable Tourism Development Use Mactor Method
Authors: Ariyani Nafiah , Umar Farhat
Published: November 2020

Tourism represents a complex multi-actor system. The successful sustainable development of tourism areas requires all stakeholders’ support and a map of the strengths, the relations, and the interests of stakeholder actors to determine appropriate institutional policies. This study aims to map stakeholders’ character at the Kedung Ombo tourism area development as a favorite potential destination in Central Java, Indonesia. Data collection used the focused group discussions method. The data analysis used was the Mactor method. This research shows that the Pemalijuana River Flow Management Office, the Indonesian State Forest Company, and the Regional Development Planning Agency were the dominant actors. The Department of Youth, Sports and Tourism, College, village government, the youth organization, and business people are relay actors. College is an autonomous actor; meanwhile, the youth organization, local government, and community are actor-dependent. The Regional Development Planning Agency Department of Youth, Sports and Tourism, college, village government, youth organizations, and business people are convergent actors who can build strong alliances. The support of BBWS Pemali Juana and Perhutani to collaborate is needed to succeed. The research findings are the basis for making a participative institutional design for the Kedung Ombo tourist area’s success and sustainability.
Peningkatan Pengetahuan dan Keterampilan Kader Posyandu dalam Pengukuran Antropometri di Kelurahan Cilandak Barat Jakarta Selatan
Authors: Fitriani Anna , Purwaningtyas Desiani Rizki
Published: November 2020

The low knowledge and skills of posyandu cadres in anthropometric measurements, from installing and measuring measuring instruments, weighing, measuring body length and height of toddlers to recording measurement results have an impact on inaccurate data collection and reporting of nutritional status. One of the contributing factors is the lack of counseling and training for posyandu cadres. Therefore, this community partnership program (PKM) provides solutions in the form of counseling and training on anthropometric measurements for posyandu cadres in West Cilandak Village. The knowledge and skills of cadres before and after the intervention were measured. The results of the analysis showed a significant increase in the average score of knowledge (11.13 to 14.67) and skills score (26.59 to 39.00) (p value = 0.001). This shows that counseling and training are effective in increasing the knowledge and skills of posyandu cadres.
Experience of launching the Doctor of Public Administration programs in Russia
Authors:   Russian Presidential Academy of National Economy and Public Administration, ZANKO TIGRAN A.
Published: November 2020

The article discusses the prerequisites, approaches to the creation as well as the experience of starting the implementation of Doctor of Public Administration programs in Russia. First of all, it is noted that MPA level programs first began to be implemented in Russia at the Institute of Public Administration and Civil Service of the RANEPA more than ten years ago. Currently, among professional officials a request for Doctor of Public Administration (DPA) top-level training programs has arisen. When developing a new DPA-level educational program for Russia, it was necessary first of all to establish the requirements and criteria for the selection of candidates. Key parameters at the same time were the level and administrative orientation of the education of applicants, mandatory work experience in senior positions. The knowledge of the applicants is checked by comprehensive entrance tests, which include testing of understanding the system and mechanisms of public administration, a practical task to check the knowledge of a foreign language, as well as interviewing and evaluating of the concept of a socially significant scientific project. The first DPA program in Russia has a modular architecture of the educational process. Each of the 12 modules, which take place every two months with an average frequency, is devoted to various aspects of state and municipal administration. At the same time, practical exercises for the development of soft skills are integrated in each DPA module. The key goal of DPA training is to prepare and defend publicly significant research in the field of state and municipal administration.
On the devaluation of expert opinion or why do we need a law about the basics of expert activity
Authors:   Autonomous non-profit organization ‘Institute of digital transformation of education’, BIKTIMIROV MARAT R. , PILIPENKO OLGA V. ,   Committee on Education and Science of the State Duma of the Russian Federation, SAFONOV MAXIM S. ,   Russian Academy of Sciences
Published: November 2020

Taking practical responsible decisions in the field of social and industrial management in the context of rapid development of digital technologies in the era of the knowledge economy is impossible without reliance on expertise. A kind of organization of activities for the production of ‘predictions’ is required, when not only an accurate assessment of the impact of certain factors and their possible interactions with each other is given, but also as a result of creative construction of scenarios for the development of processes and events, an understanding comes which factors need to be taken into account. At the same time, the expertise constantly faces criticism, calling the conclusions of experts arbitrary, unreliable and subjective. Often, expertise is confused with monitoring, evaluation, diagnosis, inspection or counseling. The authors of the article carried out a structural analysis of the content of the expertise processes in the project management vector in the digitalization era and came to the conclusion that the effectiveness of the expertise is significantly increased in case of clear regulation of this type of activity, providing the necessary status.
Biographical predictors of individual psychological characteristics included in the ‘Big Five’ of personal qualities
Authors:   Russian Presidential Academy of National Economy and Public Administration, SINYAGIN YURY V. , SINYAGINA NATALYA Y. ,   Russian Presidential Academy of National Economy and Public Administration
Published: November 2020

The article analyzes the role of biographical predictors of individual psychological characteristics that are included in the ‘Big Five’ of personal qualities. The analysis of the relationship of answers to psychobiographical questions included in the questionnaire of management potential (Y.V. Sinyagin, 2014) with the results of the ‘Big Five’ model is presented. The necessity of studying personality traits conducive to successful activities is substantiated. On the basis of empirical research, predictors of managerial success are characterized. Arguments are given for including data containing biographical information in methods of psychological analysis of a person. The authors show that the obtained empirical data can find their practical application in several areas. First of all, it is their direct use during interviews and interviews with leaders.
Increasing the efficiency of regulatory impacts to reduce information asymmetry of the insurance contract
Authors:   Financial University under the Government of the Russian Federation, BRYZGALOV DENIS V. , GRYZENKOVA JULIA V. ,   Financial University under the Government of the Russian Federation, TSYGANOV ALEXANDER A.
Published: November 2020

The article provides a comparative analysis of state policy in terms of protecting the rights of consumers of insurance services and the results of market research of 30 leading Russian insurers on the issues of informing and explaining the terms of the insurance contract. The main directions of the state policy on consumer protection at the stage of concluding an insurance contract are highlighted and described, which are expressed through informing about the insurer, about the insurer’s activities, about the insurance conditions and insurance tariff, and about consumer rights protection mechanisms. Aspects of the positive impact of the new Standard for the Protection of the Rights of Consumers (Recipients) of insurance services on the relationship of insurers and consumers, which are manifested in the specification and expansion of consumer awareness, as well as in the normalization of requirements for a place and an employee selling insurance services, are highlighted. The authors reviewed and explained the results of their own market research on the situation in terms of informing consumers and explaining the terms of insurance contracts.
Models of financing mechanism for public-private partnership projects and the specifics of their functioning
Authors:   Russian Presidential Academy of National Economy and Public Administration, LOKSHIN NIKITA V.
Published: November 2020

This article considers the public-private partnership (PPP) projects financing mechanism through the analysis of its models. The importance and necessity of using variability in structuring of different elements of financing mechanism are proved, which allows to detect the ways of their effective interaction in order to increase the efficiency of using financial resources during PPP projects implementation. The existence of basic models for PPP projects financing mechanism is justified including direct financing, project financing and financing with professional participants in the securities market. The schemes and algorithms of their functioning are presented. The article argues that in the modern conditions it is expedient to supplement the basic models for PPP projects financing mechanism by the new elements: postponed tax payments, bonds with special purpose, elements of Islamic financing mechanism models. Combining new and classic elements contributes to improvement of financing mechanism models and focuses on expanding the circle of potential investors for PPP projects.
Management by values and goals: innovative development of public corporations
Authors:   Russian Presidential Academy of National Economy and Public Administration, TOLPEGINA OLGA A. , RUDENKO EKATERINA I. ,   Russian Presidential Academy of National Economy and Public Administration
Published: November 2020

The article proposes a methodology for assessing the innovative activity of a company, one of the areas of values of state corporations: «Innovation, innovative development, the ability to upgrade». To evaluate the effectiveness, the principle of decomposition of a global goal was used with its replacement for individual specific tasks according to the designated functional subsystems and objects (blocks) of assessment, which together give a generalized description of technological, technical innovations, their development and use, implementation of the latest digital information technologies, results intellectual research, the development of new business processes, management methods, organizational forms in business practice, as well as ability to sustainable renovation, improvement and prospects for innovative growth of the company and its sustainable renewal.The scoring methodology using the developed criteria boundaries of efficiency from ambitious to low efficiency and with assignment of significance scales by expert means involves the inclusion in each assessment block of six to fifteen traditional and composite author’s indicators, the complexity of which is determined by the complexity of the subject of the study and the described process. The methodology is universal in nature, can be used for large corporations and small companies according to a reduced set of indicators, it can be used in determining ratings.
Stages for implementing the “Moscow Longevity” program
Authors:   Russian Academy of Sciences, KORNILOVA MARINA V.
Published: November 2020

The article examines the work of the “Moscow Longevity” state project/program. The analysis is carried through on the assessments given by the elderly residents of Moscow, as well as specialists from social welfare institutions responsible for the implementation of the program. The program is newly established and has been working in Moscow for over two years. The author names 4 stages for the implementation of the program: preparatory, trial, main, and “special” stages. This staging is based on the existing legal acts regulating the implementation of the project, as well as on the analysis of sociological research. The primary sources of data are: interviews conducted by the author with elderly residents of Moscow regarding the “Moscow Longevity” program (April-May 2020); surveys and focus groups conducted by the author during her work at the Moscow Institute of Additional Professional Training of Social Workers (2016-2017). The article examines statistics and publications in the mass media concerning the success of the “Moscow Longevity” project. Elderly Muscovites and employees of social organizations highly appreciated the ongoing activities, noting their relevance and timeliness, both for involving senior citizens in an active lifestyle and for adapting the elderly to a new period of life “for themselves”. Participants of the program take computer courses, study foreign languages, attend dance lessons, go to sports classes, develop artistic and aesthetic skills, master tourism, and visit cultural sites in Moscow. However, the program also has significant drawbacks, eliminating which requires significant material and technical resources as well as personnel work. Each year the participants voiced the same problems associated with the poor condition of the premises and the lack of an individual approach to activities’ organization. The “special” stage related to the situation with the coronavirus pandemic revealed a lack of computer skills among the program participants (despite the conducted computer classes) and inability to quickly adapt to new conditions.
Comparative morphometric study of adipose tissue in ovariectomized mice of different ages
Authors:   Chebotarev State Institute of Gerontology of the National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine, Ivanishchev V. , Ustymenko A. ,   State Institute of Genetic and Regenerative Medicine of the National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine; Chebotarev State Institute of Gerontology of the National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine, Kyryk V. ,   State Institute of Genetic and Regenerative Medicine of the National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine; Chebotarev State Institute of Gerontology of the National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine, Butenko G. ,   State Institute of Genetic and Regenerative Medicine of the National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine; Chebotarev State Institute of Gerontology of the National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine
Published: November 2020

It is known that estrogen deficiency leads to the dysfunction of many organs and systems, including adipose tissue. Therefore, the study of morphological changes in the components of adipose tissue during estrogen deficiency will expand our understanding of both its dysfunction and possible ways to correct it. The purpose of the study is to conduct a comparative analysis of morphometric parameters of subcutaneous adipose tissue in ovariectomized mice of different ages. Materials and methods. Subcutaneous adipose tissue samples from young (2 months) and old (14 months) mice were studied two months after ovariectomy in comparison with the samples from sham-operated animals of the same age. The number of adipocytes and capillaries per 1 mm2 of the area and the average area of adipocyte were determined on histological slices of adipose tissue. Results and discussion. It was shown that along with a significant decrease in the number of adipocytes per 1 mm2 of the area in young ovariectomized mice, a significant increase in the average area of adipocytes was observed compared with the control group of animals of the same age. In old ovariectomized animals at a slight decrease in the number of adipocytes, there was also a probable increase in their average area compared with the control group of the same age. Conclusion. The morphological properties of subcutaneous adipose tissue change significantly in the conditions of artificially induced estrogen deficiency during ovariectomy in mice.
COVID-19 Causing Persistent Cacosmia In A pregnant Patient: First Case Report.
Authors: Okar Lina , Abdelkarim Eman , Moussa Rasha , Aseel Muna
Published: November 2020

Olfactory and gustatory dysfunctions were prescribed in COVID-19
infection. Monitoring and early detection for COVID-19 infection in
pregnancy is essential. Keeping rare presentations and the impact they
have on the pregnancy in mind is crucial.This is the first case of
pregnant woman who had cacosmia as persistent symptoms after infection
Ultrasound assessment of gastric emptying in premature infants treated with non-invasive ventilatory support
Authors: Kurepa Dalibor , Schanler Richard , Weinberger Barry , Hlaing Arkar Ye
Published: November 2020

Abstract Background: Nasal CPAP introduces positive pressure of air into
both trachea and stomach, which may affect gastric emptying. The rate of
gastric emptying can be estimated by US by two validated techniques:
“antral cross-sectional area” (2-dimensional estimate of the surface
area at the gastric antrum), and “spheroid gastric volume”
(3-dimensional estimate of the stomach content volume). No study
examined gastric emptying rate in infants on bubble CPAP (bCPAP).
Objective: To compare gastric emptying rates in neonates on
machine-derived nasal CPAP (MD-nCPAP) with those on bCPAP. Methods:
Ultrasound measurements of the amount of milk in the stomach were
performed before feeding and at 1, 2, and 3 hours after the start of
feeding, using both the ACSA and spheroid methods. Rates of gastric
emptying were calculated during the “early” (1-2 hours) and “late”
(2-3 hours) phases after feeding. Results: We recruited 32 infants
(25-34 weeks gestational age). Seventeen infants were treated with
MD-nCPAP [median birth weight 1015 g (IQR: 870 to 1300), gestational
age 28 weeks (IQR: 27 to 29), postnatal age 20 days (IQR: 14 to 28)],
while 15 infants were treated with bCPAP [median birth weight 960 g
(IQR: 855 to 1070), gestational age 27 weeks (IQR: 26 to 28), postnatal
age 17 days (IQR: 15 to 25)]. Gastric emptying rates (% emptied/min)
were significantly faster in the “early” compared to the “late”
phase for all infants. There were no significant differences in the
rates of gastric emptying (either “early” or “late”) or volumes of
gastric residuals between infants receiving MD-nCPAP or bCPAP, measured
by either method. Conclusions: Gastric emptying is faster during the
“early” compared to the “late” phase. Gastric emptying rates are not
different in infants receiving MD-nCPAP vs bCPAP.
Anesthesia for Transoral Endoscopic Parathyroidectomy by Vestibular Approach (TOEPVA)
Authors: YILMAZ Fulya , BAS Koray
Published: November 2020

Introduction: After thyroid diseases, hyperparathyroidism is one of the
most common endocrine surgical disease. The increasing diagnosis of
thyroid pathologies in early stages and a societal emphasis on physical
appearances, especially in young women, have been led to development of
new surgical techniques alternative to conventional transcervical
incision consistently. Here, we describe our anaesthesia experience for
parathyroidectomy with Transoral Endoscopic Parathyroidectomy by
Vestibular Approach (TOEPVA). Material-method: Patients undergo TOEPVA
at the Health Sciences University Izmir Bozyaka Training and Research
Hospital between November 2018 and April 2019 were reviewed. Demographic
data and hemodynamic parameters were reported. Seven patients were
operated successfully by this technique none of which required
conversion to conventional open surgery. Two patient required atropine
and one patient required ephedrine during insufflation. Conclusion:
After induction of anaesthesia with propofol, remifentanil and
rocuronium; anaesthesia managed by desflurane co-administered with
continous infusion of remifentanil, provide feasible and safe
anaesthesia for TOEPVA. However, especially during hydrodissection and
insufflation, a close cooperation between surgeon and anaesthetist have
a great value to improve patient management.
Economic Impact Analysis of Improved Connectivity in Nepal
Authors: Hayashi Tadateru , Basu Das Sanchita , Singh Khadka Manbar , Isono Ikumo , Keola Souknilanh , Tsubota Kenmei , Hayakawa Kazunobu
Published: November 2020

This study estimates and analyzes the economic impact of ongoing and future infrastructure development projects in Nepal by using the geographical simulation model developed by the Institute of Developing Economies (IDE-GSM). The IDE-GSM is a computational general equilibrium model based on spatial economics. The simulation analysis reveals that ongoing infrastructure development projects in Nepal benefit the country’s economy, and that the planned connectivity improvement with India will have positive impact with anticipated major shift in mode of transport for trade. The study takes into consideration efforts by the Government of Nepal to promote and strengthen international connectivity under the South Asia Subregional Economic Cooperation framework.
Study on evolution characteristics of overburden caving and void during multi-horizontal sectional mining in steeply inclined coal seams
Authors: Yang Wen-Hua , Lai Xing-Ping , Cao Jian-Tao , Xu Hui-Cong , Fang Xian-Wei
Published: November 2020

In this paper, the evolution characteristics of overburden caving and void
during multi-horizontal sectional mining in steeply inclined coal seams are
studied. Based on the typical engineering background of steeply inclined
coal seams mining in Wudong Coal Mine, the physical simulation model is
build. The evolution characteristics of overburden caving and void during
multi-horizontal sectional mining is systematically studied, combined with
the monitoring data of overburden infrared thermal image, void ratio, void
network fractal dimension, and peak mine pressure. It is showed that,
during multi-horizontal sectional mining in steeply inclined coal seams, the
movement rule of overburden is extremely complicated, and the temperature
changes in infrared thermal image were significant.
Effect of low temperature damage on tensile strength of coal under the liquid nitrogen freezing
Authors: Su Shan-Jie , Gao Feng , Cai Cheng-Zheng , Du Meng-Lin , Wang Ze-Kai
Published: November 2020

To explore the influence of low temperature damage on the tensile strength of
coal under the liquid nitrogen freezing, the Brazilian splitting tests are
conducted on the bedding coal in this paper. The tensile strength, macro
fracture surface morphology, failure path and micro-structures of the coal
samples before and after liquid nitrogen treatment were analyzed
systematically. The results show that the tensile strength of coal after
liquid nitrogen freezing is reduced, the macro fracture surfaces with greater
roughness or fractal dimension were induced in the coal treated by liquid
nitrogen freezing during the Brazilian splitting tests, the opening and
number of the failure paths of coal after liquid nitrogen freezing increase
significantly, and the microscopically, the bedding and matrix structures of
coal are destroyed due to the temperature stress caused by large temperature
difference between the liquid nitrogen and coal matrix.