bluuebunny/crossref_metadata_2025 huggingface dataset:
Non-Intrusive Maternal Style as a Mediator between Playfulness and Children’s Development for Low-Income Chilean Adolescent Mothers
Authors: Léniz-Maturana Laura , Vilaseca Rosa , Leiva David
Published: March 2023

The aim of this study was to describe the relationship between low-income Chilean adolescent maternal playfulness and mothers’ non-intrusiveness in their children’s development and to analyze whether a mother’s non-intrusiveness mediates the relationship between maternal playfulness and children’s development. The Parental Playfulness Scale and the Subscale of Intrusiveness from the Early Head Start Research and Evaluation Project were used to assess maternal playfulness and mothers’ non-intrusiveness respectively. Ages and Stages Questionnaire 3rd Edition (ASQ-3) was applied to measure the children’s communication, gross and fine motor skills, problem-solving and personal–social development. The sample consisted of 79 mother–child dyads with children aged 10–24 months (M = 15.5, SD = 4.2) and their mothers aged 15–21 years old (M = 19.1, SD = 1.7). A bivariate analysis showed that maternal playfulness was significantly associated with communication, fine motor, problem-solving and personal–social development. Moreover, higher levels of communication, fine motor skills and problem-solving development were observed in the children of less intrusive mothers. Maternal playfulness had a significant effect on children’s development of language, problem-solving and personal–social skills when their mothers showed less intrusiveness during interaction. These findings contribute to the understanding of the interaction between adolescent mothers and their children. Active play and less intrusiveness can enhance child development.
Pediatric Myxedema Due to Autoimmune Hypothyroidism: A Rare Complication of a Common Disorder
Authors: Bonino Elisa , Matarazzo Patrizia , Buganza Raffaele , Tuli Gerdi , Munarin Jessica , Bondone Claudia , de Sanctis Luisa
Published: March 2023

In children, hypothyroidism usually presents non-specific symptoms; symptoms can emerge gradually, compromising a timely diagnosis. We report the case of a 13-year-old male, who was admitted to the hospital due to swelling of the torso and neck. Besides these symptoms, the child was healthy, except for a significant growth delay. Ultrasound evaluation and blood tests led to the diagnosis of myxedema secondary to severe hypothyroidism, which was due to autoimmune thyroiditis. Further investigations revealed pericardial effusion and pituitary hyperplasia, with hyper-prolactinemia. Treatment with levothyroxine led to edema regression and clinical, hemato-chemical and radiological improvement. After 6 months, growth velocity increased, although the recovery of growth already lost was not guaranteed. Brain MRI showed regression of pituitary hyperplasia. The diagnostic delay in this case was probably due to the patient’s apparent good health, and the underestimation of growth restriction. This report underlines the importance of growth monitoring in adolescence, a critical period for identifying endocrine conditions; if undiagnosed, these conditions can lead to serious complications, such as myxedema in hypothyroidism, with potential effects beyond growth on multiple organs.
The Extra Cost Due to Non-Adherence to Inhaled Treatments in Adolescents with Mild-to-Moderate Persistent Asthma
Authors: Dal Negro Roberto Walter , Turco Paola
Published: March 2023

Bronchial asthma has a high socio-economic impact in Western countries. Low adherence to prescribed inhalation treatments contributes to poor asthma control and the higher utilization of healthcare resources. Although adolescents usually do not comply with long-term inhaled treatments prescribed on a regular basis, the related economic consequences still are poorly investigated in Italy. Aim: A 12-month estimation of the economic impact of non-adherence to inhalation treatments in adolescents with mild-to-moderate atopic asthma. Methods: Non-smoking adolescents aged 12–19 years, without any significant comorbidity, prescribed with inhaled cortico-steroids (ICS) or ICS/long-acting beta(2)-adrenergics (LABA) via dry powder inhalers (DPIs) on a regular basis were automatically selected from the institutional database. Spirometric lung function, clinical outcomes, and pharmacological information were collected. The adolescents’ adherence to their prescribed regimen was calculated monthly. Adolescents were divided in two sub-groups based on their adherence to prescriptions: ≤70% (not adherent) or >70% (adherent), and statistically compared (Wilcoxon test, assuming p < 0.05). Results: Overall, 155 adolescents fulfilled the inclusion criteria (males, 49.0%; mean age, 15.6 years ± 2.9 SD; mean BMI, 19.1 ± 1.3 SD). Mean values of lung function were: FEV1 = 84.9% pred. ± 14.8 SD, FEV1/FVC = 87.9 ± 12.5 SD; MMEF = 74.8% pred. ± 15.1 SD and V25 = 68.4% pred. ± 14.9 SD. ICS had been prescribed in 57.4% of subjects and ICS/LABA in 42.6%. Mean adherence to original prescriptions was 46.6% ± 9.2 SD in non-adherent and 80.3% ± 6.6 SD in adherent adolescents, respectively (p < 0.001). The mean rates of hospitalizations, exacerbations, and GP visits; the average duration of absenteeism; the frequency of systemic steroids and antibiotics courses needed over the study period were significantly and substantially lower in adolescents adherent to prescriptions (all p < 0.001). The mean total annual extra cost calculated in the two sub-groups was EUR 705.8 ± 420.9 SD in non-adherent adolescents and EUR 192.1 ± 68.1 SD in adherent adolescents, respectively (p < 0.001), which was 3.7 times higher than in non-adherent adolescents. Conclusions: In adolescents, the clinical control of mild-to-moderate atopic asthma is directly and strictly related to the degree of adherence to prescribed inhalation therapies. All clinical and economic outcomes prove dramatically poor when adherence is low, and treatable asthma can be frequently mistaken for refractory asthma in these cases. Adolescents’ non-adherence impacts the burden of the disease quite substantially. Much more effective strategies centered specifically on adolescents’ asthma are needed.
Severe COVID-19 Pneumonia in a Three-Year-Old with Congenital Iron and B12 Deficiency Anemia of Unknown Etiology: A Case Report
Authors: Liapman Theodore Daniel , Bormotovs Jurijs , Reihmane Dace
Published: March 2023

Since COVID-19 first emerged in Wuhan, China, and was declared a global pandemic by the WHO, researchers have been meticulously studying the disease and its complications. Studies of severe COVID-19 disease among pediatric populations are scarce, leading to difficulty in establishing a comprehensive management approach. Case presentation: This report outlines a case of a long-standing combined iron and vitamin B12 deficiency anemia in a three-year-old treated at the Children’s Clinical University Hospital due to severe COVID-19 disease. The patient’s clinical condition coincided with the derangement of biomarkers described in the literature, including lymphopenia, increased neutrophil/lymphocyte ratio (NLR), decreased lymphocyte/C-reactive protein ratio (LCR), as well as elevated inflammatory markers such as CRP and D-dimers. The patient developed severe bilateral pneumonia requiring invasive ventilation, high-flow oxygen, immunosuppressive therapy with dexamethasone and tocilizumab, and supplementation of anemia deficits with blood transfusion and vitamin B12 administration. Conclusions: Our findings are consistent with the most important biomarkers reported in the literature indicative of severe disease progression. Additionally, poorly controlled anemia may be suggested as a potentially important risk factor for severe COVID-19 disease among children. However, additional quantitative research is required to establish the nature and severity of the risk.
Methionine Sources Differently Affect Production of Reactive Oxygen Species, Mitochondrial Bioenergetics, and Growth of Murine and Quail Myoblasts In Vitro
Authors: Stange Katja , Schumacher Toni , Miersch Claudia , Whelan Rose , Klünemann Martina , Röntgen Monika
Published: March 2023

An optimal supply of L-methionine (L-Met) improves muscle growth, whereas over-supplementation exerts adverse effects. To understand the underlying mechanisms, this study aims at exploring effects on the growth, viability, ROS production, and mitochondrial bioenergetics of C2C12 (mouse) and QM7 (quail) myoblasts additionally supplemented (100 or 1000 µM) with L-Met, DL-methionine (DL-Met), or DL-2-hydroxy-4-(methylthio)butanoic acid (DL-HMTBA). In both cell lines, all the supplements stimulated cell growth. However, in contrast to DL-Met, 1000 µM of L-Met (C2C12 cells only) or DL-HMTBA started to retard growth. This negative effect was stronger with DL-HMTBA and was accompanied by significantly elevated levels of extracellular H2O2, an indicator for OS, in both cell types. In addition, oversupplementation with DL-HMTBA (1000 µM) induced adaptive responses in mitochondrial bioenergetics, including reductions in basal (C2C12 and QM7) and ATP-synthase-linked (C2C12) oxygen consumption, maximal respiration rate, and reserve capacity (QM7). Only QM7 cells switched to nonmitochondrial aerobic glycolysis to reduce ROS production. In conclusion, we found a general negative effect of methionine oversupplementation on cell proliferation. However, only DL-HMTBA-induced growth retardation was associated with OS and adaptive, species–specific alterations in mitochondrial functionality. OS could be better compensated by quail cells, highlighting the role of species differences in the ability to cope with methionine oversupplementation.
BCL11A Expression in Breast Cancer
Authors: Kątnik Ewa , Gomułkiewicz Agnieszka , Piotrowska Aleksandra , Grzegrzółka Jędrzej , Rusak Agnieszka , Kmiecik Alicja , Ratajczak-Wielgomas Katarzyna , Dzięgiel Piotr
Published: March 2023

B-cell leukemia/lymphoma 11A (BCL11A) is a transcription factor that regulates the expression of genes involved in cell division or apoptosis. A link between high BCL11A expression and a worse prognosis has been demonstrated in patients with various cancers. The aim of this study was to investigate the expression pattern of BCL11A in breast cancer (BC) cases and mastopathy samples and to correlate the results with the clinicopathological data. The expression of the BCL11A protein was investigated using immunohistochemistry (IHC) on 200 cases of BC and 13 mastopathy samples. The level of BCL11A mRNA was determined using real-time PCR in 22 cases of BC and 6 mastopathy samples. The expression of BCL11A was also examined at the protein and mRNA levels in BC cell lines. A higher expression level of BCL11A in BC cases was shown compared to mastopathy samples. The expression level of BCL11A in BC cases and in the studied cell lines decreased with the increasing grade of histological malignancy (G). It was also negatively correlated with the primary tumor size. A significantly lower expression of BCL11A was found in BC that did not express estrogen or progesterone receptors and in triple-negative cases. The results of our research suggest that BCL11A may be relevant in the development of BC.
The Solar Radiation Climate of Saudi Arabia
Authors: Farahat Ashraf , Kambezidis Harry D. , Labban Abdulhaleem
Published: March 2023

In the present work, we investigate the solar radiation climate of Saudi Arabia, using solar radiation data from 43 sites in the country covering the period 2013–2021. These data include hourly values of global, G, and diffuse, Gd, horizontal irradiances from which the direct, Gb, horizontal irradiance is estimated. The diffuse fraction, kd; the direct-beam fraction, kb; and the ratio ke = Gd/Gb, are used in the analysis. Solar maps of the annual mean G, Gd, kd, kb, and ke are prepared for Saudi Arabia under all- and clear-sky conditions, which show interesting but explainable patterns. Additionally, the intra-annual and seasonal variabilities of these parameters are presented, and regression equations are provided. We find that Gb has a negative linear relationship with kd; the same applies to G with respect to kd or the latitude, φ, of the site. It is shown that kd and kb can reflect the scattering and absorption effects of the atmosphere on solar radiation, respectively; therefore, they can be used as atmospheric scattering and absorption indices. Part of the analysis considers the defined solar energy zones in Saudi Arabia.
The Properties of the CH3NH3PbI3/TiO2 Composite Layer Prepared from PbO-TiO2 Mesoporous Layer under Air Ambience
Authors: Chen Qinmiao , Zhu Wei , Ni Yi , Yuan Hongcun
Published: March 2023

In TiO2-based perovskite solar cells (PSC), the preparation of the CH3NH3PbI3/TiO2 composite layer is very important, since the morphology of the perovskite adsorbed onto the surface of the TiO2 nanoparticles has decisive significance for the absorption of the incident sunlight and separation of the generated carrier. The traditional two-step spin-coating method for the deposition of CH3NH3PbI3 into the porous mesoporous TiO2 layer usually suffers from filling block problems. In this study, the PbO-TiO2 mesoporous layer was prepared with various ratios of Pb:Ti in the raw materials. Morphological, optical, and element analysis of the prepared thin films indicated that Pb was gradually mixed into the TiO2 mesoporous layer with the increased Pb:Ti ratios. The element distribution characteristics of the optimal thin films showed that the distribution of Pb was uniform throughout the whole TiO2 thin film, which indicates the successful mixing of Pb into the TiO2 electrode layer. Combined with dip coating, the PbO-TiO2 mesoporous layer was prepared into a CH3NH3PbI3/TiO2 composite layer and subsequently to a solar cell device. The prepared solar cell shows a short-circuit photocurrent density of 16.4 mA/cm2, an open-circuit voltage of 900 mV, a fill factor of 61%, and a power conversion efficiency (PCE) of 9.00%. The PCE of the PSC is promoted by nearly 25% when compared with that prepared with the traditional method. The proposed preparation method that combines TiO2 nanoparticle electrode with a mixing and dip coating provides a new effective way to improve the deposition of perovskite into the mesoporous TiO2 layer, which is very helpful for the fabrication of high-efficiency and low-cost PSC.
FL* Interpretation of a Dichotomy in the Spin Susceptibility of the Cuprates
Authors: Marchetti Pieralberto
Published: March 2023

We propose that some dichotomic Fermi liquid versus non-Fermi liquid behaviours of physical quantities in hole-doped cuprates can be explained in terms of the FL* fractionalized Fermi liquid concept, introduced some years ago, even beyond the region of underdoping. The particle excitations of this FL* system are the holon carrying charge, the spinon carrying spin 1/2, gauge fluctuations coupling them and the hole as a spinon–holon bound state or resonance due to gauge binding. In our proposal, physical responses have a Fermi-liquid-type behaviour if they are dominated by the hole resonance, whereas a non-Fermi liquid behaviour appears if they are dominated by spinon–spinon (and possibly also holon–holon) gauge interactions. The specific case of spin susceptibility in the so-called "strange metal phase" is discussed. The uniform susceptibility turns out to be hole-dominated, the spin-lattice relaxation rate in the Cu sites is spinon-dominated.
Encryption Scheme of Verifiable Search Based on Blockchain in Cloud Environment
Authors: He Buzhen , Feng Tao
Published: March 2023

While transferring data to cloud servers frees users from having to manage it, it eventually raises new problems, such as data privacy. The concept of searchable encryption has drawn more and more focus in research as a means of resolving the tension between data accessibility and data privacy. Due to the lack of integrity and correctness authentication in most searchable encryption techniques, malicious cloud servers may deliver false search results to users. Based on public key encryption with searching (PEKS), the study suggests a privacy-preserving method for verifiable fuzzy keyword searches based on the Ethernet blockchain in a cloud context to overcome the aforementioned security concerns. The search user can check the accuracy and integrity of the query document using the unalterability characteristics of the Ethernet blockchain system in this scheme to prevent the cloud server from giving incorrect query results. Furthermore, a fair transaction between the cloud server and the data user is achieved and can be tracked back to the malicious user using hash functions and Ethereum smart contracts, even if the user or the cloud is malicious. Finally, the security analysis shows that, under the random oracle model, our technique fulfils the adaptive selection keyword’s semantic security. The performance assessment demonstrates that the proposed scheme outperforms other related schemes in terms of computational efficiency.
Comparison of the Strain Rate Sensitivity in AZ31 and WE43 Magnesium Alloys under Different Loading Conditions
Authors: Lei Yudong , Zhan Mei , Xin Hai , Ma Lifeng , Yuan Yuan , Zhang Hongrui , Zheng Zebang
Published: March 2023

The initial texture effect of strain rate sensitivity response in magnesium alloys was studied using the quasi in situ electron backscatter diffraction technique. The strain accumulations, under uniaxial loading of both tensile and compression along the rolling direction, showed strain rate dependency. For the AZ31 magnesium sheets with strong basal texture (max intensity to 11.2), twinning first occurs at the onset of plastic deformation, resulting in macroscopic strain rate insensitivity. With further loading, the strain rate sensitivity significantly increases (with the strain rate sensitivity coefficient m increased from 0.0025 to 0.012), arising from the initiation of slip. For the WE43 alloy sheets with weak basal texture (max intensity to 2.6), the overall deformation is sensitive to strain rate under both tensile and compression. The twinning growth rate and twinned volume fraction have been used to identify whether the process is twin-dominated or slip-dominated during the plastic deformation of a magnesium alloy.
Decrease in the Adsorption Capacity of Adsorbents in the High-Temperature Carbonate Loop Process for CO2 Capture
Authors: Kyselová Veronika , Jílková Lenka , Ciahotný Karel
Published: March 2023

In this study, the sorption capacity of limestone samples for CO2 was investigated to determine the conditions under which they can be used in the high-temperature carbonate loop process. For the work, limestone samples from the Czech Republic were used, which contained a high proportion of CaO (more than 97 wt.%). A total of 20 cycles of calcination (950 °C) and subsequent CO2 sorption–carbonation (650 °C) were performed for each limestone sample tested. The sorption capacity towards CO2 in the 20th cycle was less than 10% of the value determined in the first carbonation cycle of the samples and the most significant decrease was observed between the first and second cycles. The highest sorption capacity was determined for the Branžovy sample, which captured 268 mL of CO2/per 1 g of sorbent by chemisorption. Only 15 mL of carbon dioxide per 1 g of sorbent was bound by physisorption. However, in repeated use, the Vitošov limestone had the highest sorption capacity for CO2. For all samples, the amount of carbon dioxide bound by physisorption was in the range of 4 to 10% of the amount bound by chemisorption. Due to sintering of the material, the BET specific surface area decreased by 95 to 96%.
Functional Outcomes and Shoulder Instability in Reconstruction of Proximal Humerus Metastases
Authors: El Motassime Alessandro , Meschini Cesare , Di Costa Doriana , Rovere Giuseppe , Matrangolo Maria Rosaria , De Maio Fernando , Farsetti Pasquale , Ziranu Antonio , Maccauro Giulio , Vitiello Raffaele
Published: March 2023

(1) Background: Some of the goals of orthopedic surgical oncology are saving limbs and function. The humerus is the third most frequent site in primary tumors and one of the most involved sites for metastases. Prosthetic replacement with modular megaprosthesis is one of the treatment choices, but there are several types of complications, such as problems with function and pain. The aim of our study is to assess functional outcomes and shoulder instability in the reconstruction of proximal humerus metastases. (2) Methods: This is a retrospective observational study. Twenty-eight patients, with proximal humerus metastases, admitted to the department of Orthopaedics and Traumatology of our University Hospital between 2014 and 2022 were recruited. Each patient underwent resection and prosthetic replacement surgery with modular megaprosthesis. Clinical evaluation was assessed through MSTS score, WOSI index, and DASH score. (3) Results: Twenty patients were included in the study. Fairly good results, especially regarding pain, function, and emotional acceptance, were obtained in all three tests: DASH, MSTS, and WOSI. Patients who reported shoulder instability actually have worse outcomes than those who report having stable shoulders. In addition, patients with a resection >10 cm have worse outcomes than those who had a resection of 10 cm. No significant differences were found between the deltopectoral approach group and the lateral approach group. (4) Conclusions: Reconstructive surgery with megaprosthesis of the proximal humerus in patients with metastases can be considered a treatment option, especially in patients with pathological fractures or injuries with a high risk of fracture and good life expectancy. This study shows how this type of surgery affects instability, but in terms of functionality, pain, and patient satisfaction, it gives satisfactory results.
Genetic Diversity and Structure of Latvian Trifolium fragiferum Populations, a Crop Wild Relative Legume Species, in the Context of the Baltic Sea Region
Authors: Ruņģis Dainis E. , Andersone-Ozola Una , Jēkabsone Astra , Ievinsh Gederts
Published: March 2023

The aim of the present study was to investigate the genetic diversity and structure of eight Trifolium fragiferum populations in Latvia in the context of the Baltic Sea region. In addition, one wild population from Estonia and one from Denmark were analyzed, as well as the commercial cultivar ‘Palestine’. The genetic diversity of wild populations was low, compared to the higher diversity in the cultivar ‘Palestine’. The wild populations were differentiated into four clusters, separate from the cultivar ‘Palestine’. Three of the genetically similar Latvian populations were also geographically proximal, but the four populations geographically located near the capital, Riga, were genetically differentiated from each other. The genetic results were compared to previously published physiological studies of the same populations. The results from this study can be used as a basis for further studies of T. fragiferum populations in the Baltic Sea region, and to develop in situ and ex situ conservation strategies for this crop wild relative species.
Unrecognised Ant Megadiversity in Monsoonal Australia: The Tetramorium spininode Bolton Group in the Northern Territory
Authors: Andersen Alan N. , Brassard François , Hoffmann Benjamin D.
Published: March 2023

We document unrecognised diversity within the Tetramorium spininode Bolton group of the Australian monsoonal tropics, which has a single described species. At the time of its description, T. spininode was known from just two collections, but there have since been hundreds of collections from throughout monsoonal Australia. We document morphological and genetic (CO1) variation within the group’s fauna of the Northern Territory (NT), in the centre of its range, where collection intensity has been highest. We recognise 20 species among 124 CO1-sequenced specimens, and 32 species in total from the NT. A key to these species is provided. The most intensively sampled regions within the NT are the mesic (>1000 mm mean annual rainfall) Top End in the far north (with 14 species) and the semi-arid (500–900 mm) Sturt Plateau region to its south (13 species). Only one species is known from both regions. Given such high regional turnover and highly patchy sampling, we estimate that at least 40 species of the T. spininode group occur in the NT. Similar diversity appears to occur in Western Australia, especially in the Kimberley region, but less in Queensland. Our findings suggest that the total number of species in the T. spininode group is likely to be around 100. Our study provides further evidence that monsoonal Australia is an unrecognised global centre of ant diversity.
Batik Nitik 960 Dataset for Classification, Retrieval, and Generator
Authors: Minarno Agus Eko , Soesanti Indah , Nugroho Hanung Adi
Published: March 2023

Batik is one of the traditional heritages of Indonesia, with each motif of batik having a profound cultural and philosophical significance. This article introduces Batik Nitik 960 dataset from Yogyakarta, Indonesia. The dataset was extracted from a piece of fabric with 60 Nitik patterns. The dataset was supplied by the Paguyuban Pecinta Batik Indonesia (PPBI) Sekar Jagad Yogyakarta collection of Winotosasto Batik and the data were extracted from the APIPS Gallery. Each of the 60 categories in the collection contains 16 photographs, for a total of 960 images. The photographs were acquired with a Sony Alpha a6400, illuminated with a Godox SK II 400, and the data were compressed using the jpg file format. Each category contains four motifs rotated by 90, 180, and 270 degrees. Thus, the total number of images per motif is 16. Each class has a specific philosophical significance associated with the motif’s origins. This dataset aims to enable the training and evaluation of machine learning models for classification, retrieval, or generation of a new batik pattern using a generative adversarial network. To our knowledge, this study is the first to present a Batik Nitik dataset equipped with philosophical significance that is freely accessible.
On Liquid Flow Maldistribution through Investigation of Random Open-Structure Packings
Authors: Dzhonova-Atanasova Daniela , Stefanova Konstantina , Nakov Svetoslav
Published: March 2023

The optimal design of packed columns for separation processes is strongly dependent on an accurate prediction of the fluid flows in the packing. Insufficient knowledge about the complex factors and mechanisms governing hydrodynamic effects is compensated for by empirical information. The present study fills the gap in experimental data about the liquid phase distribution in plastic Raschig Super-Ring (RSRP) packing and plastic Ralu–Flow (RF) packing. These belong to the family of widely used random packings with an open lattice structure characterized by high mass transfer efficiency and a low pressure drop. The study was performed using the liquid collection method with a device with concentric annular collection sections at the packing outlet. Large-scale liquid maldistribution in the central and peripheral zones of the packed bed were evaluated in comparison data on competing random and structured packings. The effects of the packing size and the liquid load on the radial distribution of the superficial liquid velocity, wall flow formation and the maldistribution factor were investigated and analyzed. The results contribute to deepening the knowledge about the phenomenon of large-scale liquid flow maldistribution in packed columns, as well as to design enhancement.
Prediction of the as Low as Diagnostically Acceptable CT Dose for Identification of the Inferior Alveolar Canal Using 3D Convolutional Neural Networks with Multi-Balancing Strategies
Authors: Al-Ekrish Asma’a , Hussain Syed Azhar , ElGibreen Hebah , Almurshed Rana , Alhusain Luluah , Hörmann Romed , Widmann Gerlig
Published: March 2023

Ionizing radiation is necessary for diagnostic imaging and deciding the right radiation dose is extremely critical to obtain a decent quality image. However, increasing the dosage to improve the image quality has risks due to the potential harm from ionizing radiation. Thus, finding the optimal as low as diagnostically acceptable (ALADA) dosage is an open research problem that has yet to be tackled using artificial intelligence (AI) methods. This paper proposes a new multi-balancing 3D convolutional neural network methodology to build 3D multidetector computed tomography (MDCT) datasets and develop a 3D classifier model that can work properly with 3D CT scan images and balance itself over the heavy unbalanced multi-classes. The proposed models were exhaustively investigated through eighteen empirical experiments and three re-runs for clinical expert examination. As a result, it was possible to confirm that the proposed models improved the performance by an accuracy of 5% to 10% when compared to the baseline method. Furthermore, the resulting models were found to be consistent, and thus possibly applicable to different MDCT examinations and reconstruction techniques. The outcome of this paper can help radiologists to predict the suitability of CT dosages across different CT hardware devices and reconstruction algorithms. Moreover, the developed model is suitable for clinical application where the right dose needs to be predicted from numerous MDCT examinations using a certain MDCT device and reconstruction technique.
Voltage-Dependent Anion Channel 1 Expression in Oral Malignant and Premalignant Lesions
Authors: Allon Irit , Pettesh Jacob , Livoff Alejandro , Schlapobersky Mark , Nahlieli Oded , Michaeli Eli
Published: March 2023

Background: The voltage-dependent anion channel 1 protein (VDAC1) plays a role in cellular metabolism and survival. It was found to be down or upregulated (overexpressed) in different malignancies but it was never studied in application to oral lesions. The purpose of this study was to retrospectively evaluate the expression of VDAC1 in biopsies of oral premalignant, malignant, and malignancy-neutral lesions and to examine the possible correlations to their clinicopathological parameters. Materials and methods: 103 biopsies including 49 oral squamous cell carcinoma, 33 epithelial dysplasia, and 21 fibrous hyperplasia samples were immunohistochemically stained with anti-VDAC1 antibodies for semi-quantitative evaluation. The antibody detection was performed with 3,3′-diaminobenzidine (DAB). The clinicopathological information was examined for possible correlations with VDAC1. Results: VDAC1 expression was lower in oral squamous cell carcinoma 0.63 ± 0.40 and in oral epithelial dysplasia 0.61 ± 0.36 biopsies compared to fibrous hyperplasia biopsies 1.45 ± 0.28 (p < 0.01 for both; Kruskal–Wallis test). Conclusion: Oral squamous cell carcinoma and epithelial dysplasia tissues demonstrated decreased VDAC1 protein expression if compared to fibrous hyperplasia samples, but were not different from each other, suggesting that the involvement of VDAC1 in oral carcinogenesis is an early stage event, regulating cells to live or die.
Role of Changes in Driving Pressure and Mechanical Power in Predicting Mortality in Patients with Acute Respiratory Distress Syndrome
Authors: Wu Huang-Pin , Leu Shaw-Woei , Lin Shih-Wei , Hung Chen-Yiu , Chen Ning-Hung , Hu Han-Chung , Huang Chung-Chi , Kao Kuo-Chin
Published: March 2023

Driving pressure (ΔP) and mechanical power (MP) are associated with increased mortality in patients with acute respiratory distress syndrome (ARDS). We aimed to investigate which was better to predict mortality between changes in ΔP and MP. We reanalyzed data from a prospective observational cohort study of patients with ARDS in our hospital. Serial ΔP and MP values were calculated. The factors associated with survival were analyzed. Binary logistic regression showed that age (odds ratio (OR), 1.012; 95% confidence interval (CI), 1.003–1.022), Sequential Organ Failure assessment (SOFA) score (OR, 1.144; 95% CI, 1.086–1.206), trauma (OR, 0.172; 95% CI, 0.035–0.838), ΔP (OR, 1.077; 95% CI, 1.044–1.111), change in ΔP (OR, 1.087; 95% CI, 1.054–1.120), and change in MP (OR, 1.018; 95% CI, 1.006–1.029) were independently associated with 30-day mortality. Change in MP, change in ΔP, and SOFA scores were superior to ΔP in terms of the accuracy of predicting 30-day mortality. In conclusion, calculating change in ΔP is easy for respiratory therapists in clinical practice and may be used to predict mortality in patients with ARDS.
Pitfalls of Thrombotic Microangiopathies in Children: Two Case Reports and Literature Review
Authors: Mocanu Adriana , Bogos Roxana Alexandra , Lazaruc Tudor Ilie , Cianga Anca Lavinia , Lupu Vasile Valeriu , Ioniuc Ileana , Alecsa Mirabela , Lupu Ancuta , Ivanov Anca Viorica , Miron Ingrith Crenguta , Starcea Iuliana Magdalena
Published: March 2023

Thrombotic microangiopathy can present itself in the form of several clinical entities, representing a real challenge for diagnosis and treatment in pediatric practice. Our article aims to explore the evolution of two rare cases of pediatric thrombotic thrombocytopenic purpura (TTP) and atypical hemolytic uremic syndrome (aHUS) with extremely similar clinical pictures, which, coincidentally, presented at approximately the same time in our hospital. These cases and our literature review demonstrate the multiple facets of thrombotic microangiopathy, which can produce various determinations and salient manifestations even among the pediatric population. TTP and aHUS may represent genuine diagnostic pitfalls through the overlap of their clinical and biological findings, although they develop through fundamentally different mechanisms that require different therapeutic approaches. As a novelty, we underline that COVID-19 infection cannot be excluded as potential trigger for TTP and aHUS in our patients and we predict that other reports of such an association will follow, raising a complex question of COVID-19’s implication in the occurrence and evolution of thrombotic microangiopathies. On this matter, we conducted literature research that resulted in 15 cases of COVID-19 pediatric infections associated with either TTP or aHUS. Taking into consideration the morbidity associated with TTP and aHUS, an elaborate differential diagnosis and prompt intervention are of the essence.
Application of Drug Testing Platforms in Circulating Tumor Cells and Validation of a Patient-Derived Xenograft Mouse Model in Patient with Primary Intracranial Ependymomas with Extraneural Metastases
Authors: Liang Muh-Lii , Yeh Ting-Chi , Huang Man-Hsu , Wu Pao-Shu , Wu Shih-Pei , Huang Chun-Chao , Yen Tsung-Yu , Ting Wei-Hsin , Hou Jen-Yin , Huang Jia-Yun , Ding Yi-Huei , Zheng Jia-Huei , Liu Hsi-Che , Ho Che-Sheng , Chen Shiu-Jau , Hsieh Tsung-Han
Published: March 2023

Primary intracranial ependymoma is a challenging tumor to treat despite the availability of multidisciplinary therapeutic modalities, including surgical resection, radiotherapy, and adjuvant chemotherapy. After the completion of initial treatment, when resistant tumor cells recur, salvage therapy needs to be carried out with a more precise strategy. Circulating tumor cells (CTCs) have specifically been detected and validated for patients with primary or recurrent diffused glioma. The CTC drug screening platform can be used to perform a mini-invasive liquid biopsy for potential drug selection. The validation of potential drugs in a patient-derived xenograft (PDX) mouse model based on the same patient can serve as a preclinical testing platform. Here, we present the application of a drug testing model in a six-year-old girl with primary ependymoma on the posterior fossa, type A (EPN-PFA). She suffered from tumor recurrence with intracranial and spinal seeding at 2 years after her first operation and extraneural metastases in the pleura, lung, mediastinum, and distant femoral bone at 4 years after initial treatment. The CTC screening platform results showed that everolimus and entrectinib could be used to decrease CTC viability. The therapeutic efficacy of these two therapeutic agents has also been validated in a PDX mouse model from the same patient, and the results showed that these two therapeutic agents significantly decreased tumor growth. After precise drug screening and the combination of focal radiation on the femoral bone with everolimus chemotherapy, the whole-body bone scan showed significant shrinkage of the metastatic tumor on the right femoral bone. This novel approach can combine liquid biopsy, CTC drug testing platforms, and PDX model validation to achieve precision medicine in rare and challenging tumors with extraneural metastases.
Importance of Anatomical Variation of the Hepatic Artery for Complicated Liver and Pancreatic Surgeries: A Review Emphasizing Origin and Branching
Authors: Malviya Kapil Kumar , Verma Ashish
Published: March 2023

Knowledge of anatomical variations of the hepatic artery from its origin to intrahepatic segmentation is of utmost importance for planning upper abdominal surgeries including liver transplantation, pancreatoduodenectomy, and biliary reconstruction. The origin and branching pattern of the hepatic artery was thoroughly described by the classification of Michels and Hiatt. Some rare variations of the hepatic artery were classified by Kobayashi and Koops. By the use of the multidetector computed tomography (MDCT) technique, the branching pattern of the hepatic artery can be visualized quite accurately. Unawareness of these arterial variations may lead to intraoperative injuries such as necrosis, abscess, and failure of the liver and pancreas. The origin and course of the aberrant hepatic arteries are crucial in the surgical planning of carcinoma of the head of the pancreas and hepatobiliary surgeries. In liver transplant surgeries, to minimize intraoperative bleeding complications and postoperative thrombosis, exact anatomy of the branching of the hepatic artery, its variations and intrahepatic course is of utmost importance. This review discusses variations in the anatomy of the hepatic artery from its origin to branching by the use of advanced imaging techniques and its effect on the liver, pancreatic, biliary and gastric surgeries.
The Role of the Marrakesh Treaty in Supporting Access to Printed Material for People Who Are Blind or Visually Impaired: A Critical Discussion of the Results of an Empirical Study Conducted in Six European Countries
Authors: Ferri Delia , Rossello Giulia
Published: March 2023

Less than 7% of published works are accessible. To overcome this book famine, the Marrakesh Treaty was enacted with the view of enhancing access to published works for people with visual impairments, blind people, and people that are otherwise print-disabled. Leveraging survey data from six European countries (Italy, Ireland, Sweden, Germany, Hungary, and the Netherlands), we investigate the respondents’ knowledge of the Marrakesh Treaty and whether they experienced improved access to printed material after its implementation. The results of the survey show that people who are blind and use braille printers are more likely to report an improvement in accessing printed material, suggesting that the exceptions provided for in the Marrakesh Treaty best support the reproduction and availability of copyrighted works in braille rather than other formats.
Five-Year Clinical Performance of Complex Class II Resin Composite and Amalgam Restorations—A Retrospective Study
Authors: Santos Maria Jacinta M. C. , Rêgo Heleine Maria C. , Siddique Imad , Jessani Abbas
Published: March 2023

The aim of this retrospective study was to investigate the clinical performance of posterior complex resin composite (RC) and amalgam (AM) restorations after a five-year period. One hundred and nineteen complex Class II restorations placed by dental students were evaluated using the USPHS criteria. Data were analyzed using Chi-square, Mann–Whitney, and Wilcoxon tests at a 0.05 level of significance. After five years, the percentages of clinically satisfactory complex Class II RC and AM restorations were 78% and 76.8%, respectively. The main reasons for the failure of AM restorations included secondary caries (Bravo—10.1%), defective marginal adaptation (Charlie—8.7%), and fracture of the tooth (Bravo—7.2%). RC restorations presented failures related to the fracture of the restoration (Bravo—16%) and defective marginal adaptation (Charlie—8.2%). There was a significantly higher incidence of secondary caries for AM restorations (AM—10.1%; RC—0%; p = 0.0415) and a higher number of fractures for RC restorations (AM—4.3%; RC—16%; p = 0.05). Regarding anatomy, AM restorations presented a significantly higher number of Alfa scores (49.3%) compared to RC restorations (22.4%) (p = 0.0005). The results of the current study indicate that complex class II RC and AM restorations show a similar five year clinical performance.
Radiometric Correction of Multispectral Field Images Captured under Changing Ambient Light Conditions and Applications in Crop Monitoring
Authors: Xue Beibei , Ming Bo , Xin Jiangfeng , Yang Hongye , Gao Shang , Guo Huirong , Feng Dayun , Nie Chenwei , Wang Keru , Li Shaokun
Published: March 2023

Applications of unmanned aerial vehicle (UAV) spectral systems in precision agriculture require raw image data to be converted to reflectance to produce time-consistent, atmosphere-independent images. Complex light environments, such as those caused by varying weather conditions, affect the accuracy of reflectance conversion. An experiment was conducted here to compare the accuracy of several target radiance correction methods, namely pre-calibration reference panel (pre-CRP), downwelling light sensor (DLS), and a novel method, real-time reflectance calibration reference panel (real-time CRP), in monitoring crop reflectance under variable weather conditions. Real-time CRP used simultaneous acquisition of target and CRP images and immediate correction of each image. These methods were validated with manually collected maize indictors. The results showed that real-time CRP had more robust stability and accuracy than DLS and pre-CRP under various conditions. Validation with maize data showed that the correlation between aboveground biomass and vegetation indices had the least variation under different light conditions (correlation all around 0.74), whereas leaf area index (correlation from 0.89 in sunny conditions to 0.82 in cloudy days) and canopy chlorophyll content (correlation from 0.74 in sunny conditions to 0.67 in cloudy days) had higher variation. The values of vegetation indices TVI and EVI varied little, and the model slopes of NDVI, OSAVI, MSR, RVI, NDRE, and CI with manually measured maize indicators were essentially constant under different weather conditions. These results serve as a reference for the application of UAV remote sensing technology in precision agriculture and accurate acquisition of crop phenotype data.
UAV Deployment Optimization for Secure Precise Wireless Transmission
Authors: Shen Tong , Xia Guiyang , Ye Jingjing , Gu Lichuan , Zhou Xiaobo , Shu Feng
Published: March 2023

This paper develops an unmanned aerial vehicle (UAV) deployment scheme in the context of the directional modulation-based secure precise wireless transmissions (SPWTs) to achieve more secure and more energy efficiency transmission, where the optimal UAV position for the SPWT is derived to maximize the secrecy rate (SR) without frequency diverse array (FDA) and injecting any artificial noise (AN) signaling. To be specific, the proposed scheme reveals that the optimal position of UAV for maximizing the SR performance has to be placed at the null space of Eves channel, which impels the received energy of the confidential message at the unintended receiver deteriorating to zero, whilst benefits the one at the intended receiver by achieving its maximum value. Moreover, the highly cost FDA structure is eliminated and transmit power is all allocated for transmitting a useful message which shows its energy efficiency. Finally, simulation results verify the optimality of our proposed scheme in terms of the achievable SR performance.
Tsallis Entropy of a Used Reliability System at the System Level
Authors: Kayid Mohamed , Alshehri Mashael A.
Published: March 2023

Measuring the uncertainty of the lifetime of technical systems has become increasingly important in recent years. This criterion is useful to measure the predictability of a system over its lifetime. In this paper, we assume a coherent system consisting of n components and having a property where at time t, all components of the system are alive. We then apply the system signature to determine and use the Tsallis entropy of the remaining lifetime of a coherent system. It is a useful criterion for measuring the predictability of the lifetime of a system. Various results, such as bounds and order properties for the said entropy, are investigated. The results of this work can be used to compare the predictability of the remaining lifetime between two coherent systems with known signatures.
Change-Point Detection for Multi-Way Tensor-Based Frameworks
Authors: Qin Shanshan , Zhou Ge , Wu Yuehua
Published: March 2023

Graph-based change-point detection methods are often applied due to their advantages for using high-dimensional data. Most applications focus on extracting effective information of objects while ignoring their main features. However, in some applications, one may be interested in detecting objects with different features, such as color. Therefore, we propose a general graph-based change-point detection method under the multi-way tensor framework, aimed at detecting objects with different features that change in the distribution of one or more slices. Furthermore, considering that recorded tensor sequences may be vulnerable to natural disturbances, such as lighting in images or videos, we propose an improved method incorporating histogram equalization techniques to improve detection efficiency. Finally, through simulations and real data analysis, we show that the proposed methods achieve higher efficiency in detecting change-points.
About the Entropy of a Natural Number and a Type of the Entropy of an Ideal
Authors: Minculete Nicuşor , Savin Diana
Published: March 2023

In this article, we find some properties of certain types of entropies of a natural number. We are studying a way of measuring the “disorder” of the divisors of a natural number. We compare two of the entropies H and H¯ defined for a natural number. An useful property of the Shannon entropy is the additivity, HS(pq)=HS(p)+HS(q), where pq denotes tensor product, so we focus on its study in the case of numbers and ideals. We mention that only one of the two entropy functions discussed in this paper satisfies additivity, whereas the other does not. In addition, regarding the entropy H of a natural number, we generalize this notion for ideals, and we find some of its properties.