bluuebunny/crossref_metadata_2025 huggingface dataset:
Efficacy and Adverse Events of Apatinib Salvage Treatment for Refractory Diffuse Malignant Peritoneal Mesothelioma: A Pilot Study
Authors: Yang Zhi-Ran , Su Yan-Dong , Ma Ru , Wu He-Liang , Li Yan
Published: July 2022

Objective

To investigate the clinical efficacy and adverse events (AEs) of apatinib salvage treatment for diffuse malignant peritoneal mesothelioma (DMPM) that has failed to respond to the recommended treatments.

Methods

27 patients with refractory DMPM were treated with apatinib at our center from April 2014 to October 2020, at the initial dose of 250 mg/d. The dose was reduced to 125 mg/d when serious adverse events (SAEs) occurred. 28-day was set as a treatment cycle. The frequency of follow up was once every 28 days. The efficacy evaluation was conducted according to the Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 criteria and the serum tumor markers before and after apatinib treatment. The safety assessment was performed with the National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) version 5.0. The primary endpoints were objective response rate (ORR) and disease control rate (DCR), and the secondary endpoints were AEs.

Results

The 27 patients completed a median treatment-cycle of 15.0, ranging from 5.1 to 39.4 cycles. At the median follow-up of 14.3 (4.8-51.8) months, median overall survival (OS) was 59.4 months, median apatinib-treatment-related survival (ATRS) was 14.0 (4.8-36.8) months. Complete response (CR) was observed in 0 case (0.0%), partial response (PR) in 4 cases (14.8%), stable disease (SD) in 12 cases (44.4%), and progression disease (PD) in 11 cases (40.7%). The ORR was 14.8%, and DCR was 59.3%. The median serum CA125 values before and after apatinib treatment were 32.9 (7.0-4592.4) U/mL and 29.7 (6.1-4327.4) U/mL, respectively (P=0.009). The common AEs were hypertension (6/27; 22.2%), hand-foot syndrome (5/27; 18.5%), albuminuria (4/27; 14.8%), anemia (4/27; 14.8%), leukopenia (4/27; 14.8%), rash (2/27; 7.4%), fatigue (2/27; 7.4%), oral ulcers (2/27; 7.4%), hoarseness (2/27; 7.4%), nausea/vomiting (2/27; 7.4%), diarrhea (2/27; 7.4%), headache (1/27; 3.7%), and fever (1/27; 3.7%). The incidence rate of grade III/IV AEs was 16.2%.

Conclusions

Apatinib is effective in treating refractory DMPM, with promising efficacy and acceptable safety.
A Radiomics Nomogram Integrated With Clinic-Radiological Features for Preoperative Prediction of DNA Mismatch Repair Deficiency in Gastric Adenocarcinoma
Authors: Tong Yahan , Li Jiaying , Chen Jieyu , Hu Can , Xu Zhiyuan , Duan Shaofeng , Wang Xiaojie , Yu Risheng , Cheng Xiangdong
Published: July 2022

Purpose

To develop and validate a radiomics nomogram integrated with clinic-radiological features for preoperative prediction of DNA mismatch repair deficiency (dMMR) in gastric adenocarcinoma.

Materials and Methods

From March 2014 to August 2020, 161 patients with pathologically confirmed gastric adenocarcinoma were included from two centers (center 1 as the training and internal testing sets, n = 101; center 2 as the external testing sets, n = 60). All patients underwent preoperative contrast-enhanced computerized tomography (CT) examination. Radiomics features were extracted from portal-venous phase CT images. Max-relevance and min-redundancy (mRMR) and least absolute shrinkage and selection operator (LASSO) methods were used to select features, and then radiomics signature was constructed using logistic regression analysis. A radiomics nomogram was built incorporating the radiomics signature and independent clinical predictors. The model performance was assessed using receiver operating characteristic (ROC) curve analysis, calibration curve, and decision curve analysis (DCA).

Results

The radiomics signature, which was constructed using two selected features, was significantly associated with dMMR gastric adenocarcinoma in the training and internal testing sets (P < 0.05). The radiomics signature model showed a moderate discrimination ability with an area under the ROC curve (AUC) of 0.81 in the training set, which was confirmed with an AUC of 0.78 in the internal testing set. The radiomics nomogram consisting of the radiomics signature and clinical factors (age, sex, and location) showed excellent discrimination in the training, internal testing, and external testing sets with AUCs of 0.93, 0.82, and 0.83, respectively. Further, calibration curves and DCA analysis demonstrated good fit and clinical utility of the radiomics nomogram.

Conclusions

The radiomics nomogram combining radiomics signature and clinical characteristics (age, sex, and location) may be used to individually predict dMMR of gastric adenocarcinoma.
Colorectal Cancer Chemotherapy Drug Bevacizumab May Induce Muscle Atrophy Through CDKN1A and TIMP4
Authors: Xu Qun , Li Jinyou , Wu Yue , Zhou Wenjing , Xu Zherong
Published: July 2022

The muscle in the organism has the function of regulating metabolism. Long-term muscle inactivity or the occurrence of chronic inflammatory diseases are easy to induce muscle atrophy. Bevacizumab is an antiangiogenic drug that prevents the formation of neovascularization by inhibiting the activation of VEGF signaling pathway. It is used in the first-line treatment of many cancers in clinic. Studies have shown that the use of bevacizumab in the treatment of tumors can cause muscle mass loss and may induce muscle atrophy. Based on bioinformatics analysis, this study sought the relationship and influence mechanism between bevacizumab and muscle atrophy. The differences of gene and sample expression between bevacizumab treated group and control group were studied by RNA sequencing. WGCNA is used to find gene modules related to bevacizumab administration and explore biological functions through metascape. Differential analysis was used to analyze the difference of gene expression between the administration group and the control group in different muscle tissues. The key genes timp4 and CDKN1A were obtained through Venn diagram, and then GSEA was used to explore their biological functions in RNA sequencing data and geo chip data. This study studied the role of bevacizumab in muscle through the above methods, preliminarily determined that timp4 and CDKN1A may be related to muscle atrophy, and further explored their functional mechanism in bevacizumab myotoxicity.
In-vivo Sino-Atrial Node Mapping in Children and Adults With Congenital Heart Disease
Authors: Kharbanda Rohit K. , van Schie Mathijs S. , Ramdat Misier Nawin L. , Wesselius Fons J. , Zwijnenburg Roxanne D. , van Leeuwen Wouter J. , van de Woestijne Pieter C. , de Jong Peter L. , Bogers Ad J. J. C. , Taverne Yannick J. H. J. , de Groot Natasja M. S.
Published: July 2022

Background:

Sinus node dysfunction (SND) and atrial tachyarrhythmias frequently co-exist in the aging patient with congenital heart disease (CHD), even after surgical correction early in life. We examined differences in electrophysiological properties of the sino-atrial node (SAN) area between pediatric and adult patients with CHD.

Methods

Epicardial mapping of the SAN was performed during sinus rhythm in 12 pediatric (0.6 [0.4–2.4] years) and 15 adult (47 [40–55] years) patients. Unipolar potentials were classified as single-, short or long double- and fractionated potentials. Unipolar voltage, relative R-to-S-amplitude ratio and duration of all potentials was calculated. Conduction velocity (CV) and the amount of conduction block (CB) was calculated.

Results

SAN activity in pediatric patients was solely observed near the junction of the superior caval vein and the right atrium, while in adults SAN activity was observed even up to the middle part of the right atrium. Compared to pediatric patients, the SAN region of adults was characterized by lower CV, lower voltages, more CB and a higher degree of fractionation. At the earliest site of activation, single potentials from pediatrics consisted of broad monophasic S-waves with high amplitudes, while adults had smaller rS-potentials with longer duration which were more often fractionated.

Conclusions

Compared to pediatric patients, adults with uncorrected CHD have more inhomogeneous conduction and variations in preferential SAN exit site, which are presumable caused by aging related remodeling. Long-term follow-up of these patients is essential to demonstrate whether these changes are related to development of SND and also atrial tachyarrhythmias early in life.
Severe Pediatric Asthma Therapy: Mepolizumab
Authors: Ullmann Nicola , Peri Francesca , Florio Olivia , Porcaro Federica , Profeti Elisa , Onofri Alessandro , Cutrera Renato
Published: July 2022

There is a growing need for advanced treatment in children with persistent and severe asthma symptoms. As a matter of fact, between 2 and 5% of asthmatic children experience repeated hospitalizations and poor quality of life despite optimized treatment with inhaled glucocorticoid plus a second controller. In this scenario, mepolizumab, a humanized monoclonal antibody, has proven to be effective in controlling eosinophil proliferation by targeting interleukin-5 (IL-5), a key mediator of eosinophil activation pathways. Mepolizumab is approved since 2015 for adults at a monthly dose of 100 mg subcutaneously and it has been approved for patients ≥ 6 years of age in 2019. Especially in children aged 6 to 11 years, mepolizumab showed a greater bioavailability, with comparable pharmacodynamics parameters as in the adult population. The recommended dose of 40 mg every 4 weeks for children aged 6 through 11 years, and 100 mg for patients ≥ 12 years provides appropriate concentration and proved similar therapeutic effects as in the adult study group. A marked reduction in eosinophil counts clinically reflects a significant improvement in asthma control as demonstrated by validated questionnaires, reduction of exacerbation rates, and the number of hospitalizations. Finally, mepolizumab provides a safety and tolerability profile similar to that observed in adults with adverse events mostly of mild or moderate severity. The most common adverse events were headache and injection-site reaction. In conclusion, mepolizumab can be considered a safe and targeted step-up therapy for severe asthma with an eosinophilic phenotype in children and adolescents.
Prevalence and Related Factors of White Coat Hypertension and Masked Hypertension in Shunde District, Southern China
Authors: Zhu Hailan , Zheng Haoxiao , Liang Xiaoyan , Huang Chunyi , Sun Lichang , Liu Xiong , Qiu Min , Mai Weiyi , Huang Yuli
Published: July 2022

Background: White coat hypertension (WCH) and masked hypertension (MH) can increase the risk of target organ damage. Home blood pressure monitoring is an important method for detecting WCH and MH. However, the prevalence and related factors of WCH and MH in China have been rarely reported.

Objective: To explore the prevalence and related factors associated with white coat hypertension (WCH) and masked hypertension (MH) in Shunde District, Southern China.

Methods: This study recruited subjects from the Physical Examination Center in Shunde Hospital, Southern Medical University. Office blood pressure and home blood pressure values were collected using the home blood pressure monitor with telemedicine device and office blood pressure monitor, and the prevalence of WCH and MH was calculated by the values. Multivariate logistic regression was used to explore the related factors for WCH and MH.

Results: Four-hundred and sixty-one participants (61% male), with an average age of 49 years, were included. The prevalence of WCH and MH was 5.1 and 15.2%, respectively. Multivariate logistic regression analysis showed that smoking (OR = 4.71, 95% CI = 1.05–21.15) and family history of coronary heart disease (OR = 4.51, 95% CI = 1.08–18.93) were associated with higher odds of WCH. The associated factors for higher odds of MH were smoking (OR = 2.83, 95% CI = 1.11–7.23), family history of hypertension (OR = 2.17, 95% CI = 1.11–4.26) and family history of coronary heart disease (OR = 2.82, 95% CI = 1.07–7.45).

Conclusion: WCH and MH are highly prevalent in the Physical Examination Center in Shunde Hospital, Southern Medical University. We found smoking and family history of coronary heart disease were related factors for WCH, and smoking, family history of hypertension and coronary heart disease were associated with the odds of MH. Home blood pressure monitoring with a telemedicine device should be recommended to identity abnormal BP phenotype.
The Diverse Roles of 17β-Estradiol in Non-Gonadal Tissues and Its Consequential Impact on Reproduction in Laying and Broiler Breeder Hens
Authors: Hanlon Charlene , Ziezold Clara J. , Bédécarrats Grégoy Y.
Published: July 2022

Estradiol-17β (E2) has long been studied as the primary estrogen involved in sexual maturation of hens. Due to the oviparous nature of avian species, ovarian production of E2 has been indicated as the key steroid responsible for activating the formation of the eggshell and internal egg components in hens. This involves the integration and coordination between ovarian follicular development, liver metabolism and bone physiology to produce the follicle, yolk and albumen, and shell, respectively. However, the ability of E2 to be synthesized by non-gonadal tissues such as the skin, heart, muscle, liver, brain, adipose tissue, pancreas, and adrenal glands demonstrates the capability of this hormone to influence a variety of physiological processes. Thus, in this review, we intend to re-establish the role of E2 within these tissues and identify direct and indirect integration between the control of reproduction, metabolism, and bone physiology. Specifically, the sources of E2 and its activity in these tissues via the estrogen receptors (ERα, ERβ, GPR30) is described. This is followed by an update on the role of E2 during sexual differentiation of the embryo and maturation of the hen. We then also consider the implications of the recent discovery of additional E2 elevations during an extended laying cycle. Next, the specific roles of E2 in yolk formation and skeletal development are outlined. Finally, the consequences of altered E2 production in mature hens and the associated disorders are discussed. While these areas of study have been previously independently considered, this comprehensive review intends to highlight the critical roles played by E2 to alter and coordinate physiological processes in preparation for the laying cycle.
Expression Patterns Divergence of Reciprocal F1 Hybrids Between Gossypium hirsutum and Gossypium barbadense Reveals Overdominance Mediating Interspecific Biomass Heterosis
Authors: Li Tengyu , Wang Fuqiu , Yasir Muhammad , Li Kui , Qin Yuan , Zheng Jing , Luo Kun , Zhu Shouhong , Zhang Hua , Jiang Yurong , Zhang Yongshan , Rong Junkang
Published: July 2022

Hybrid breeding has provided an impetus to the process and achievement of a higher yield and quality of crops. Interspecific hybridization is critical for resolving parental genetic diversity bottleneck problems. The reciprocal interspecific hybrids and their parents (Gossypium hirsutum and Gossypium barbadense) have been applied in this study to elucidate the transcription regulatory mechanism of early biomass heterosis. Phenotypically, the seed biomass, plant height over parent heterosis, leaf area over parent heterosis, and fresh and dry biomass were found to be significantly higher in hybrids than in parents. Analysis of leaf areas revealed that the one-leaf stage exhibits the most significant performance in initial vegetative growth vigor and larger leaves in hybrids, increasing the synthesis of photosynthesis compounds and enhancing photosynthesis compound synthesis. Comparative transcriptome analysis showed that transgressive down-regulation (TDR) is the main gene expression pattern in the hybrids (G. hirsutum × G. barbadense, HB), and it was found that the genes of photosystem I and Adenosine triphosphate (ATP)-binding may promote early growth vigor. Transgressive up-regulation (TUR) is the major primary gene expression pattern in the hybrids (G. barbadense × G. hirsutum, BH), and photosystem II-related genes mediated the performance of early biomass heterosis. The above results demonstrated that overdominance mediates biomass heterosis in interspecific hybrid cotton and the supervisory mechanism divergence of hybrids with different females. Photosynthesis and other metabolic process are jointly involved in controlling early biomass heterosis in interspecific hybrid cotton. The expression pattern data of transcriptome sequencing were supported using the qRT-PCR analysis. Our findings could be useful in theoretical and practical studies of early interspecific biomass heterosis, and the results provide potential resources for the theoretical and applied research on early interspecific biomass heterosis.
Interaction of Nitrate Assimilation and Photorespiration at Elevated CO2
Authors: Krämer Konrad , Brock Judith , Heyer Arnd G.
Published: July 2022

It has been shown repeatedly that exposure to elevated atmospheric CO2 causes an increased C/N ratio of plant biomass that could result from either increased carbon or – in relation to C acquisition - reduced nitrogen assimilation. Possible reasons for diminished nitrogen assimilation are controversial, but an impact of reduced photorespiration at elevated CO2 has frequently been implied. Using a mutant defective in peroxisomal hydroxy-pyruvate reductase (hpr1-1) that is hampered in photorespiratory turnover, we show that indeed, photorespiration stimulates the glutamine-synthetase 2 (GS) / glutamine-oxoglutarate-aminotransferase (GOGAT) cycle, which channels ammonia into amino acid synthesis. However, mathematical flux simulations demonstrated that nitrate assimilation was not reduced at elevated CO2, pointing to a dilution of nitrogen containing compounds by assimilated carbon at elevated CO2. The massive growth reduction in the hpr1-1 mutant does not appear to result from nitrogen starvation. Model simulations yield evidence for a loss of cellular energy that is consumed in supporting high flux through the GS/GOGAT cycle that results from inefficient removal of photorespiratory intermediates. This causes a futile cycling of glycolate and hydroxy-pyruvate. In addition to that, accumulation of serine and glycine as well as carboxylates in the mutant creates a metabolic imbalance that could contribute to growth reduction.
Evolutionary Dynamics of the Repeatome Explains Contrasting Differences in Genome Sizes and Hybrid and Polyploid Origins of Grass Loliinae Lineages
Authors: Moreno-Aguilar María Fernanda , Inda Luis A. , Sánchez-Rodríguez Aminael , Arnelas Itziar , Catalán Pilar
Published: July 2022

The repeatome is composed of diverse families of repetitive DNA that keep signatures on the historical events that shaped the evolution of their hosting species. The cold seasonal Loliinae subtribe includes worldwide distributed taxa, some of which are the most important forage and lawn species (fescues and ray-grasses). The Loliinae are prone to hybridization and polyploidization. It has been observed a striking two-fold difference in genome size between the broad-leaved (BL) and fine-leaved (FL) Loliinae diploids and a general trend of genome reduction of some high polyploids. We have used genome skimming data to uncover the composition, abundance, and potential phylogenetic signal of repetitive elements across 47 representatives of the main Loliinae lineages. Independent and comparative analyses of repetitive sequences and of 5S rDNA loci were performed for all taxa under study and for four evolutionary Loliinae groups [Loliinae, Broad-leaved (BL), Fine-leaved (FL), and Schedonorus lineages]. Our data showed that the proportion of the genome covered by the repeatome in the Loliinae species was relatively high (average ∼ 51.8%), ranging from high percentages in some diploids (68.7%) to low percentages in some high-polyploids (30.7%), and that changes in their genome sizes were likely caused by gains or losses in their repeat elements. Ty3-gypsy Retand and Ty1-copia Angela retrotransposons were the most frequent repeat families in the Loliinae although the relatively more conservative Angela repeats presented the highest correlation of repeat content with genome size variation and the highest phylogenetic signal of the whole repeatome. By contrast, Athila retrotransposons presented evidence of recent proliferations almost exclusively in the Lolium clade. The repeatome evolutionary networks showed an overall topological congruence with the nuclear 35S rDNA phylogeny and a geographic-based structure for some lineages. The evolution of the Loliinae repeatome suggests a plausible scenario of recurrent allopolyploidizations followed by diploidizations that generated the large genome sizes of BL diploids as well as large genomic rearrangements in highly hybridogenous lineages that caused massive repeatome and genome contractions in the Schedonorus and Aulaxyper polyploids. Our study has contributed to disentangling the impact of the repeatome dynamics on the genome diversification and evolution of the Loliinae grasses.
HAPPE: A Tool for Population Haplotype Analysis and Visualization in Editable Excel Tables
Authors: Feng Cong , Wang Xingwei , Wu Shishi , Ning Weidong , Song Bo , Yan Jianbin , Cheng Shifeng
Published: July 2022

Haplotype identification, characterization and visualization are important for large-scale analysis and use in population genomics. Many tools have been developed to visualize haplotypes, but it is challenging to display both the pattern of haplotypes and the genotypes for each single SNP in the context of a large amount of genomic data. Here, we describe the tool HAPPE, which uses the agglomerative hierarchical clustering algorithm to characterize and visualize the genotypes and haplotypes in a phylogenetic context. The tool displays the plots by coloring the cells and/or their borders in Excel tables for any given gene and genomic region of interest. HAPPE facilitates informative displays wherein data in plots are easy to read and access. It allows parallel display of several lines of values, such as phylogenetic trees, P values of GWAS, the entry of genes or SNPs, and the sequencing depth at each position. These features are informative for the detection of insertion/deletions or copy number variations. Overall, HAPPE provides editable plots consisting of cells in Excel tables, which are user-friendly to non-programmers. This pipeline is coded in Python and is available at https://github.com/fengcong3/HAPPE.
Positive Classification Advantage of Categorizing Emotional Faces in Patients With Major Depressive Disorder
Authors: Zhao Lun , Wang Xiaoyu , Sun Gang
Published: July 2022

This study investigated whether patients with MDD (major depressive disorder) have deficits in emotional face classification as well as the perceptual mechanism. We found that, compared with the control group, MDD patients exhibited slower speed and lower accuracy in emotional face classification. In normal controls, happy faces were classified faster than sad faces, i.e., positive classification advantage (PCA), which disappeared under the inverted condition. MDD patients showed PCA similar to the control group, although the inversion effects of happy and sad faces were more evident. These data suggest that the dysfunction of categorizing emotional faces in MDD patients could be due to general impairment in decoding facial expressions, reflecting the more common perceptual motion defects in face expression classification.
Embodied Interaffectivity in the Emergence and Maintenance of Group Cohesion
Authors: Jones Cheryl , Pino-Pasternak Deborah , Volet Simone
Published: July 2022

Group cohesion is an affect-laden construct, with a large body of research indicating its importance for success of teams. Surprisingly, it has received scant attention in collaborative learning contexts, and little is known about its development as dynamically emergent in the spontaneous, interdependent actions of actors during groupwork. This paper details an illustrative case analysis which took an embodied perspective to explore the role of interaffectivity in the emergence and maintenance of cohesion in one small group of university students who reported a highly positive and productive experience of collaborative science activities over a semester. The case analysis made visible group cohesion as unfolding and enactive in the myriad ephemeral and seemingly inconsequential microlevel behaviors that evolved into macro-temporal patterns of positive embodied interaffectivity, magnifying their visibility and collective impact. A fine-grained embodiment lens unveiled how participants cocreated collaborative affordances in actions that involved corporeal orientation as well as use of space, task, and other material artifacts. Task-related humor within routine task interaction offered the potential for establishing group cohesion in early group life, but also posed a potential threat to task-focused cohesiveness, requiring careful modulation at critical task points. Attentiveness not only to the task but importantly, to one another as interpersonal attentiveness, appeared to be a key factor in developing and maintaining group cohesion, also demonstrating collaborative learning as a process of orienting to and understanding tasks through one another. An embodiment lens highlighted mutual attentiveness in the ongoing orienter-orientee microprocesses that facilitated group orientation early in group life, and in reorienting to positive embodied interaffectivity when the group reconvened for their joint science activities in subsequent weeks.
Explanations for the Cloudy Evidence That Theory Benefits Health Promotion
Authors: Cummins Kevin M.
Published: July 2022

Persuasive arguments for using theory have been influential in health behavior and health promotion research. The use of theory is expected to improve intervention outcomes and facilitate scientific advancement. However, current empirical evaluations of the benefits of theory have not consistently demonstrated strong effects. A lack of resolution on this matter can be attributed to several features of the current body of evidence. First, the use of theory may be confounded with other features that impact health-related outcomes. Second, measurement of theory use has not been reliable. Third, the field conflates models and theories. Lastly, the evidentiary status and applicability of theories are not considered. Addressing these challenges during the execution of meta-analyses and designing original research specifically to estimate the benefits of theory could improve research and practice.
Regional Social Development Gap and Regional Coordinated Development Based on Mixed-Methods Research: Evidence From China
Authors: Liu Weiwei , Liu Zhiwei , Wang Lian , Liu Haiming , Wang Yan
Published: July 2022

Due to the continuous acceleration of the global urbanization process, the unbalanced development of regional cities has become an unavoidable reality under the rapid economic and social development of China. Unbalanced social development will affect coordinated and sustainable economic development, regional ethnic unity, and political and social stability. This research uses data from the 2011–2015 period, 2016–2020 period, and various special development plans of 35 large and medium cities, combines qualitative analysis and quantitative analysis, establishes a comprehensive evaluation model, and conducts cluster analysis, using standard deviation. The coefficient of variation aims to measure and study whether the gap in China’s regional social development has continued to widen over the past decade. This study found that: (1) From the overall national perspective, there are obvious differences in the level of social development in the development plans of 35 large and medium-sized cities. The social development level of each large and medium-sized city has been improved to a certain extent, and the social development gap between cities has also been reduced to a certain extent. (2) From the 2011–2015 period to the 2016–2020 period, the social development gap between the three regions of my country’s eastern, central, and western regions has declined. (3) The trend of social development disparity within the three major regions of the eastern, central, and western regions is not the same. The internal social development gap in the eastern region shows a downward trend, while the internal social development gap in the central and western regions shows an upward trend. This study provides a valuable reference for rapidly urbanizing developing countries in the process of globalization.
Patients With Severe Alcohol-Related Cognitive Impairment Improve in Flexibility When Abstinence Is Maintained: A Comparative Study With Alzheimer’s Disease
Authors: Clergue-Duval Virgile , Barré Thomas , Cognat Emmanuel , Brichet Anne-Laure , Géraud Claire , Azuar Julien , Michaud Philippe , Lecallier Dorothée , Arfaoui-Geffroy Sonia , Hispard Eric , Paquet Claire , Bellivier Frank , Questel Frank , Vorspan Florence ,   all members of the ResAlCog care network
Published: July 2022

The disease progression of severe alcohol-related cognitive impairment (ARCI) is debated. The aim of this study was to compare the cognitive change of patients with severe ARCI in inpatient setting to that of patients with Alzheimer’s disease (AD). Fifteen consecutive patients with severe ARCI were recruited between 2013 and 2015. They received inpatient detoxification, neurological assessment, and inpatient cognitive rehabilitation in specialized facilities. Twelve patients, with documented AD matched on sex and initial cognitive impairment severity, were selected. All have benefited from two neuropsychological assessments. The neurocognitive change was tested in both groups with pair-wised Wilcoxon tests. ARCI and AD patients’ time course was compared with Mann–Whitney–Wilcoxon test. In ARCI group, first assessment occurred at 2.9 (± 2.2) months of abstinence and follow-up 6.5 (± 2.9) months later, the mean age was 56.5 (± 7.4) years, and 12 were men. In AD group, follow-up occurred at 12.8 (± 2.9) months (p < 10–3), the mean age was 72.3 (± 8.4) years (p < 10–3), and 10 were men. ARCI patients significantly improved on one executive function test (TMT-B; p < 0.05), while AD patients have worsened memory subtests on Free-and-Cued-Selective-Reminding Test (p < 0.05). These tests showed a statistically different change between severe ARCI and AD group (p < 0.05). Severe ARCI patients have improved in executive functioning, discernible on the TMT-B test, in specific care setting, including abstinence maintenance and rehabilitation. The disease progression was different from that observed in AD patients.
A Theoretical Review on the Role of English as a Foreign Language Teachers’ Self-Disclosure in Shaping Classroom Climate and Immediacy
Authors: Qin Jing
Published: July 2022

Teachers’ interpersonal communication skills and strategies have been widely considered effective pedagogical tools in academia. Despite the growing research in this area, unraveling the power of English as a foreign language (EFL) teachers’ self-disclosure in shaping classroom climate and immediacy has been relatively left intact. To fill the gap and provide new insights into this strand of research, the present article was an effort to present a theoretical analysis of the interplay of self-disclosure, classroom climate, and immediacy. In so doing, the definitions, conceptualizations, dimensions, underlying theories, and empirical evidence in support of the interaction among these three constructs were presented. Moreover, practical implications for EFL teachers, teacher trainers, and L2 scholars were provided to raise their awareness of interpersonal communication skills and their outcomes in academia. Finally, the study provided some suggestions for further research in this line of inquiry.
How Does Servant Leadership Influences Creativity? Enhancing Employee Creativity via Creative Process Engagement and Knowledge Sharing
Authors: Chen Meizhao , Zada Muhammad , Khan Jawad , Saba Noor Ul
Published: July 2022

Grounding on social exchange theory and using the creative process engagement as a lens, this article study investigates the influence of servant leadership on employee creativity. In addition, the research examines the role of knowledge sharing in the link between servant leadership and employee creativity. Time lag method was used to collect the data from 242 employees and 57 managers employed in Chinese publicly listed companies. The data collection was divided into two parts. The subordinates were asked to rate servant leadership, their creative process engagement behavior, and knowledge sharing. The supervisors were asked to rate their associates regarding employee creativity. According to the results, employees creative process engagement behaviors mediated servant leadership and employees’ creativity. In addition, the link between servant leadership and employees’ creativity was strengthened by knowledge sharing. A detailed model is also provided, highlighting the significance of leadership, work engagement, knowledge sharing in fostering employee creativity in the Asian environment.
Characterizing Creative Thinking and Creative Achievements in Relation to Symptoms of Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder
Authors: Stolte Marije , Trindade-Pons Victoria , Vlaming Priscilla , Jakobi Babette , Franke Barbara , Kroesbergen Evelyn H. , Baas Matthijs , Hoogman Martine
Published: July 2022

Previous research on ADHD and ASD has mainly focused on the deficits associated with these conditions, but there is also evidence for strengths. Unfortunately, our understanding of potential strengths in neurodevelopmental conditions is limited. One particular strength, creativity, has been associated with both ADHD and ASD. However, the distinct presentations of both conditions beg the question whether ADHD and ASD associate with the same or different aspects of creativity. Therefore, the current study investigated the links between ADHD and ASD symptoms, creative thinking abilities, and creative achievements. To investigate the spectrum of ADHD and ASD symptoms, self-reported ADHD and ASD symptoms, convergent (Remote Associations Test) and divergent thinking (Alternative Uses Task) and creative achievements (Creative Achievement Questionnaire) were assessed in a self-reportedly healthy sample of adults (n = 470). We performed correlation analysis to investigate the relation between ADHD/ASD symptoms and creativity measures. In a second phase of analysis, data from an adult ADHD case-control study (n = 151) were added to investigate the association between ADHD symptoms and divergent thinking in individuals with and without a diagnosis of ADHD.

Our analysis revealed that having more ADHD symptoms in the general population was associated with higher scores on all the outcome measures for divergent thinking (fluency, flexibility, and originality), but not for convergent thinking. Individuals with an ADHD diagnosis in the case-control sample also scored higher on measures of divergent thinking. Combining data of the population based and case-control studies showed that ADHD symptoms predict divergent thinking up to a certain level of symptoms. No significant associations were found between the total number of ASD symptoms and any of the creativity measures. However, explorative analyses showed interesting links between the ASD subdomains of problems with imagination and symptoms that relate to social difficulties. Our findings showed a link between ADHD symptoms and divergent thinking abilities that plateaus in the clinical spectrum of symptoms. For ASD symptoms, no relation was found with creativity measures. Increasing the knowledge about positive phenotypes associated with neurodevelopmental conditions and their symptom dimensions might aid psychoeducation, decrease stigmatization and improve quality of life of individuals living with such conditions.
Immersive Media-Based Tourism Emerging Challenge of VR Addiction Among Generation Z
Authors: Saneinia Saba , Zhou Rongting , Gholizadeh Ali , Asmi Fahad
Published: July 2022

The virtual reality (VR) applications in entertainment and tourism industry have become growingly intense among generation Z. Interestingly, some pilot research on tourism studied concluded the positive impact of its flow experience on adoption of VR tourism, which is also driving the risk of immersive addictive. In the context of tourism and information and communication technology (ICT)-based innovation, there is a lack of immersive addictive behavior (IAB)-related literature. In addition, during the currently ongoing pandemic crisis, VR technology has gained particular importance in the tourism industry among generation Z. The present venture underlines the mechanism of IAB, investigates the VR addiction while underlining the cognitive abilities of individuals. This study applies empirical framework of cognitive–behavioral model. Results demonstrate that in the case of VR tourism, the immersive experience (presence and flow) determines the addictive behavior. Furthermore, VR imagery (VI), psychological curiosity (PC), and VR convenience (VRC) have significant influence on the VR presence and immersive flow. Moreover, the practical and theoretical implications have been discussed in the current research to prevent IAB.
The Prevalence and the Associated Sociodemographic-Occupational Factors of Professional Burnout Among Health Professionals During COVID-19 Pandemic in Malang, Indonesia: A Cross-Sectional Study
Authors: Daryanto Besut , Putri Frilya Rachma , Kurniawan Jemmy , Ilmawan Muhammad , Fajar Jonny Karunia
Published: July 2022

Background

Since 2020, Indonesian health professionals have been affected by burnout as the physiological impact due to the COVID-19 pandemic. Malang has contributed to a substantial number of new daily cases and death rates in East Java, an epicenter of COVID-19 in Indonesia. However, a study about how burnout affected Malang health professionals was never conducted.

Objectives

This research aimed to assess the prevalence and factors associated with burnout among health professionals during the COVID-19 pandemic in Malang, Indonesia.

Materials and Methods

A cross-sectional study was carried out with an online survey conducted in 5 major hospitals in Malang. We conducted a study about the prevalence rate of burnout in Malang and the association between sociodemographic factors, occupational hazards, and the Maslach Burnout Inventory-Human Services Survey (MBI-HSS). The associations were presented as odds ratio (OR) and 95% confidence interval (CI).

Results

We analyzed 1,077 health professionals in Malang. Our result showed that the prevalence of burnout among health professionals in Malang is 22.0%. Respondents under the age of 30 tend to experience a higher level of burnout by 3.4-fold (OR = 3.43, p-value < 0.001), compared with those over the age of 40 years. Our data showed that respondents working longer than 100 h/week tend to experience burnout by 3.8-fold (OR = 3.83, p-value < 0.001).

Conclusion

Approximately one-fifth of the health professionals in Malang suffered from burnout during the COVID-19 pandemic, and MBI-HSS subscales are strongly associated with age and work hours.
Lexical Features of Economic Legal Policy and News in China Since the COVID-19 Outbreak
Authors: Liu Jiaqi
Published: July 2022

Lexical features are influenced by different languages and genres. The study of lexical features in different genres of texts on the same topic is helpful to understand the universalities and peculiarities of languages. This study constructs a research on the lexical feature and word collocations of two self-build corpora (China's economic Legal Policy Corpus and English News Corpus during the COVID-19 pandemic), the methods of Quantitative Linguistics and context interpretation are adopted. It was found that: (1) the word length, word frequency, word cluster and high frequency word distribution in English economic news and Chinese economic legal policies are influenced by language and genre to some extent, and they conform to different functional image distribution; (2) during the COVID-19 pandemic, “development” has been the focus of China's economic legal policies and English news, the two have attached importance to economic recovery and taken a positive attitude toward it in different ways. These findings suggest that: (1) There are some universalities and peculiarities between English economic news and Chinese economic legal policies in the distribution of lexical feature; (2) there is a certain synchronization between laws and news, and both of them maintain a positive and objective attitude toward the economic development during the pandemic. This study carries out a macroscopic investigation on internal structure and external interpretation, which enriches the study on lexical features and cultural features of language and provides some references for relevant studies.
Biochar Amendments Facilitate Methane Production by Regulating the Abundances of Methanogens and Methanotrophs in Flooded Paddy Soil
Authors: Gao Jiakai , Liu Ling , Shi Zhaoyong , Lv Jialong
Published: July 2022

The application of biochar in conjunction with fertilizer in agricultural production is one of the most promising types of management to improve soil quality. However, the effects on the soil microbial community and methane (CH4) emissions from the interactive mechanisms of biochar combined with fertilizer are unclear. In this study, soil column trial was conducted to monitor the surface water nitrogen, dissolved organic carbon (DOC) and CH4 emission dynamics during the process of leaching. Additionally, bacterial and archaeal communities of the soil (0-10 cm) amended with biochar derived from different pyrolysis temperatures (300°C, 500°C, and 700°C) were also analyzed. High-throughput sequencing revealed that the soil archaeal and bacterial community diversities increased under the biochar amendments. The CH4 emission flux of all the treatments in the whole leaching period ranged from 0.0001 to 2.04 μg m-2 h-1, and the DOC ranged from 1.86 to 24.4 mg L-1. Our results showed that biochar amendments significantly increase the soil pH, total nitrogen (TN), and DOC contents, while inhibiting the loss of NO3− N during leaching. In addition, biochar addition increased the paddy soil CH4 emissions, which ascribed to the increasing ratio of the abundances of methanogens to methanotrophs. Consequently, the higher CH4 emissions were probably caused by the stimulation of methanogenic archaea under the biochar amendments. Thus, the results obtained in this study can be applied to guide the application of biochar on greenhouse gas emissions in paddy soil.
Farming Systems, Food Security and Farmers' Awareness of Ecosystem Services in Inland Valleys: A Study From Côte d'Ivoire and Ghana
Authors: Alemayehu Tesfahun , Assogba Guy Marius , Gabbert Silke , Giller Ken E. , Hammond James , Arouna Aminou , Dossou-Yovo Elliott Ronald , Ven Gerrie W. J. van de
Published: July 2022

Inland valleys (IVs) in West African countries have increasingly been used for crop production, including rice cultivation. Though it is widely assumed that IVs have a high potential to contribute to food security of West African countries, a comprehensive assessment of farming systems addressing agricultural, institutional, food security, poverty, and ecosystem indicators is still lacking. This study characterizes IVs' smallholder farm households at the regional and farm type level using Rural Household Multiple Indicator Survey (RHoMIS) data collected from 733 randomly selected farm households in four agro-ecological regions, i.e., Bouaké and Gagnoa in Cote d'Ivoire, and Ahafo Ano North and Ahafo Ano South in Ghana. A farm typology is developed, and farm households are characterized with regard to demographic, agricultural, economic, and institutional indicators. Furthermore, farm households' food security and poverty status, and the importance of rice in the portfolio of crops, is assessed. Finally, farmers' awareness of different ecosystem services (ES) for their food security is examined. Four farm types are identified, i.e., farmers who rent all the land cultivated, farmers who own some land and rent extra land, farmers who own and cultivate all their land, and farmers cultivating only a part of the land they own. We find that the variation in farm households' demographic, economic, and institutional characteristics is greater between regions than within regions. Crop production, either for direct consumption or marketing, especially rice production, is the main contributor to daily energy intake, followed by wild food consumed. Still, a substantial percentage of the farm households (16–38%) in all regions cannot meet minimum daily energy requirements. Farmers of all farm types, and in all regions, attach high relevance to IVs' provisioning ES, particularly the ability to provide food. A majority of farmers in all regions highlighted the relevance of regulating ES, including climate regulation, water storage, and groundwater values for their wellbeing. In contrast, farmers attached relatively lower relevance to cultural ES. Interventions to improve national rice production need to acknowledge and preserve the diversity ES that IVs provide to smallholder farm households.
Absorbable Artificial Dura Versus Nonabsorbable Artificial Dura in Decompressive Craniectomy for Severe Traumatic Brain Injury: A Retrospective Cohort Study in Two Centers
Authors: Zhang Zhong-Ding , Zhao Li-Yan , Liu Yi-Ru , Zhang Jing-Yu , Xie Shang-Hui , Lin Yan-Qi , Tang Zhuo-Ning , Fang Huang-Yi , Yang Yue , Li Shi-Ze , Liu Jian-Xi , Sheng Han-Song
Published: July 2022

Background

Severe traumatic brain injury (TBI) patients usually need decompressive craniectomy (DC) to decrease intracranial pressure. Duraplasty is an important step in DC with various dura substitute choices. This study aims to compare absorbable dura with nonabsorbable dura in duraplasty for severe TBI patients.

Methods

One hundred and three severe TBI patients who underwent DC and dura repair were included in this study. Thirty-nine cases used absorbable artificial dura (DuraMax) and 64 cases used nonabsorbable artificial dura (NormalGEN). Postoperative complications, mortality and Karnofsky Performance Scale (KPS) score in one year were compared in both groups.

Results

Absorbable dura group had higher complication rates in transcalvarial cerebral herniation (TCH) (43.59% in absorbable dura group vs. 17.19% in nonabsorbable dura group, P = 0.003) and CSF leakage (15.38% in absorbable dura group vs. 1.56% in nonabsorbable dura group, P = 0.021). But severity of TCH described with hernial distance and herniation volume demonstrated no difference in both groups. There was no statistically significant difference in rates of postoperative intracranial infection, hematoma progression, secondary operation, hydrocephalus, subdural hygroma and seizure in both groups. KPS score in absorbable dura group (37.95 ± 28.58) was statistically higher than nonabsorbable dura group (49.05 ± 24.85) in one year after operation (P = 0.040), while no difference was found in the rate of functional independence (KPS ≥ 70). Besides, among all patients in this study, TCH patients had a higher mortality rate (P = 0.008), lower KPS scores (P < 0.001) and lower functionally independent rate (P = 0.049) in one year after surgery than patients without TCH.

Conclusions

In terms of artificial biological dura, nonabsorbable dura is superior to absorbable dura in treatment of severe TBI patients with DC. Suturable nonabsorbable dura has fewer complications of TCH and CFS leakage, and manifest lower mortality and better prognosis. Postoperative TCH is an important complication in severe TBI which usually leads to a poor prognosis.