bluuebunny/crossref_metadata_2025 huggingface dataset:
Hellenistic Painted Ceramics from Olbia
Authors:   PhD in History, Senior Research Fellow, Department of Ancient Archaeology, Institute of Archaeology of the National Academy of Sciences of Ukraine, Kotenko Viktoria
Published: July 2022

The article is devoted to the publication of a small collection of Hellenistic painted pottery from Olbia. The studying of certain categories of archaeological material provides an opportunity to explore in detail the various aspects of their characteristics and to outline issues related primarily to its origin. Among the promising vectors of the study of Olbian ceramic complex are finds of the Hellenistic period and isolation of some series of imported pottery of the Black Sea North region production. One of the representative collections of Hellenistic pottery from Olbia is stored in the Scientific Repository of the Institute of Archaeology of the National Academy of Sciences of Ukraine. It is represented by materials of excavations of the second half of the 20th century. First of all, the so-called red clay painted pottery is very interesting, the origin of which is still debated in historiography. Among the items selected for the study, table jugs predominate, which are represented by a fairly wide range of variations of profile parts and ornamental compositions. The decorations are the following: encircling lines, plant motifs or a combination of them; the painting is done mainly with dark red paint. The collection also includes fragments of ceramic flasks, which are rare forms of ware in the Black Sea North region and were used as small containers. Profile parts of vessels are described separately. The article also contains the description of the morphology of different types of jugs and their capacity. Particular attention is paid to the origin of Hellenistic ceramics. It has been found that such pottery was probably made in Tauric Chersonesos. Despite the need of chemical and technical analyses of the clay composition and clarification of the raw materials origin, it should be noted that such indicators as mass character, typological similarity and the presence of these products in situ in the places of pottery production are quite convincing factors in the process of their attribution. Its availability in the ceramic complex of Olbia testifies to the existence of interpoleis contacts in the Black Sea North region, in particular to certain connections of this centre with Taurica in the 4th – 2nd centuries BC, which has already been recorded archaeologically on the amphorae materials. Therefore, a representative collection of Hellenistic pottery from the excavations at Olbia supplemented new information about the life of the polis during its active development.
Multimodal Assessment of Systemic Blood Flow in Infants
Authors: Surak Aimann , Lalitha Renjini , Bitar Eyad , Hyderi Abbas , Hicks Matt , Cheung Po Yin , Kumaran Kumar
Published: July 2022

The assessment of systemic blood flow is a complex and comprehensive process with clinical, laboratory, and technological components. Despite recent advancements in technology, there is no perfect bedside tool to quantify systemic blood flow in infants that can be used for clinical decision making. Each option has its own merits and limitations, and evidence on the reliability of these physiology-based assessment processes is evolving. This article provides an extensive review of the interpretation and limitations of methods to assess systemic blood flow in infants, highlighting the importance of a comprehensive and multimodal approach in this population.
Formación inicial para docentes de preescolar: experiencias durante la pandemia de COVID-19 en Guatemala
Authors: Muralles Marín María Alejandra
Published: July 2022

El distanciamiento social como medida ante la pandemia de Covid-19 alteró los procesos de enseñanza, incluido el de las instituciones dedicadas a la formación inicial docente para preescolar, en las que, debido a la migración a entornos virtuales de aprendizaje, se llevaron a cabo esfuerzos para adaptar sus procesos formativos de forma emergente. Ante ello, se planteó como objetivo describir las valoraciones que hacen las personas docentes formadoras y docentes en formación de la cohorte 2018-2020 de Magisterio Inicial sobre las adecuaciones curriculares realizadas a raíz de la pandemia de Covid-19 en dos centros de formación docente privados de la ciudad de Guatemala. Se realizó un estudio cualitativo, de diseño narrativo de tópico, con alcance descriptivo en el que se contó con una muestra por disposición de 22 participantes. Se llevaron a cabo grupos focales con doce docentes en formación y entrevistas con diez personas docentes formadoras, para conocer sus experiencias durante el confinamiento. La información recolectada se procesó con la técnica de análisis por comparación constante con la ayuda del software Atlas.ti. Entre los hallazgos pueden mencionarse buenas prácticas, como el modelaje del acompañamiento emocional en el aula y la diversificación de la mediación pedagógica para incluir a las familias que fungieron como coeducadoras en el proceso escolar; desafíos como la urgencia en la inclusión de TIC en las asignaturas psicopedagógicas y la generación de espacios para práctica docente virtual; y posibles propuestas para atenderlos, tales como procesos de capacitación para la formación en entornos virtuales de aprendizaje tanto para personal docente formador como docentes en formación.
Escala de sensibilidad intercultural en estudiantes de nivel universitario de carreras de pedagogía en Chile
Authors: Ramírez Pavelic Mónica Antonieta , Contreras Salinas Sylvia
Published: July 2022

El estudio se centró en la validación y aplicación de una escala de sensibilidad intercultural. El objetivo de la investigación fue conocer y comparar el grado de sensibilidad intercultural de las distintas disciplinas y nivel de práctica que cursa el estudiantado de pedagogía de la Facultad de Educación de una institución de educación superior privada de Chile; para ello se consideró una división por tipos de práctica (inicial, intermedia o profesional). Se trabajó con un muestreo aleatorio estratificado proporcionado, conformado por más del 30 % del estudiantado de cada una de las seis carreras de la Facultad de Educación, compuesta por 227 estudiantes de nivel universitario de dicha Facultad (19,4 % hombres y 77,1 % mujeres), quienes respondieron un cuestionario autoaplicado. Inicialmente, se realizó una adaptación cultural de los ítems con la ayuda de personas juezas expertas. Para la validación de la escala se aplicó un análisis de fiabilidad para todos los ítems. Tras su aplicación a la muestra chilena, los resultados de validación del instrumento arrojaron un Alpha de Cronbach de 0,87, donde las carreras de Educación Diferencial, Educación Básica, Inglés y Educación Parvularia, se encontraban sobre el promedio total de los diferenciados, lo que reflejó una alta sensibilidad intercultural, mientras que Educación Física y Matemáticas se hallaban por debajo de este promedio. Como conclusión, se confirma la validez y fiabilidad del instrumento, así como su adecuación al contexto local. Asimismo, se considera que esta escala podría utilizarse como una medida válida y fiable en el estudiantado universitario chileno de pedagogía, lo que se ve favorecido, además, por su fácil y rápida aplicación.
Modelos de educación musical en el siglo XXI: el modelo de mediación musical para el compromiso social
Authors: Lorenzo de Reizabal Margarita
Published: July 2022

La noción de compromiso social como un elemento transversal en el diseño curricular en las instituciones educativas ha prevalecido en los últimos 25 años en España de una manera muy desigual y dispar en su implementación diaria dentro del aula. La educación musical que se imparte en las escuelas de música, liceos y conservatorios debe tener un impacto positivo en el bienestar social de la comunidad y también debe contribuir a aliviar las disfunciones sociales del contexto en el que dichas instituciones están imbricadas, creando cohesión social y sentimientos de pertenencia e identidad comunitaria. Sin embargo, existe cierta inercia en la perpetuación de modelos tradicionales de educación musical donde no hay espacio para proyectos innovadores con compromiso social auténtico. Para paliar este problema, se presenta el modelo educativo de mediación e intervención a través de la música, que agrega una nueva orientación a la oferta tradicional en la educación musical. Este trabajo tiene los siguientes objetivos: 1) ofrecer algunas reflexiones sobre los modelos educativos tradicionales a través de una taxonomía novedosa; y 2) presentar el modelo de mediación musical que puede servir de apoyo a proyectos de educación socio-comunitaria e integrar el compromiso social dentro de la acción pedagógica. La principal contribución de este trabajo es la presentación de una clasificación de modelos actualizados de educación musical, incluidos los más recientes, como el modelo de gamificación, y la introducción en esta clasificación del modelo de mediación musical. En este nuevo modelo educativo, los profesores de música utilizan su conocimiento musical aplicado a actividades educativas para propiciar cambios y transformaciones en las personas, contribuyendo así a paliar las disfunciones sociales del medio ambiente y contribuyendo al estado de bienestar de la comunidad. Entre las conclusiones más relevantes destacan la necesidad de poner al día la formación del profesorado de música, ampliando sus competencias en materia de educación socio-comunitaria, o bien optando por una especialización en los nuevos modelos. Se constata la necesidad de diseñar estrategias didácticas, metodologías y actividades destinadas al desarrollo del modelo de mediación social y promover la investigación educativa en este ámbito. Finalmente, la taxonomía presentada responde a la realidad observada y generada a partir del escenario mundial actual, pero lejos de ser una clasificación estática, es previsible que deberá ser revisada en diálogo continuo con el contexto en los próximos años y décadas.
El arpa eólica en la literatura latinoamericana y española (del Romanticismo al Modernismo)
Authors: Cuvardic García Dorde
Published: July 2022

En Occidente, la lira y el arpa han sido adoptadas como metáforas de la poesía desde hace más de dos milenios. En estos mismos términos debería comprenderse la práctica del tópico del arpa eólica en la historia de la literatura occidental. Como objetivo principal, el presente artículo realiza un recorrido por las variantes connotativas que ha adquirido el tópico del arpa eólica en la literatura latinoamericana y española, desde su aparición en el siglo XVIII hasta el siglo XX, más allá del núcleo semántico fijo que ha tenido en todas las épocas culturales. Como resultado principal del análisis, se observa que la representación literaria de este instrumento se ha canalizado, sobre todo, como tópico metapoético. Concluimos que, originado en el norte de Europa, el arpa eólica ha sido incorporada en la literatura española y latinoamericana como alegoría del poeta y del proceso de la creación poética. Fernán Caballero, Rosalía de Castro, Gaspar Núñez de Arce, Melchor de Palau y Catalá y Fernando Sánchez de Fuentes nos ofrecen modulaciones en la literatura española, mientras que José Asunción Silva, José María Rivas Groot, Enrique González Martínez, Justo Sierra, Fabio Fiallo y, sobre todo, Rubén Darío, nos ofrecen ejemplos en la latinoamericana.
Polyphyllin I alleviates lipopolysaccharide-induced inflammation reduces pyroptosis in BEAS-2B and HPAEC cells by inhibiting NF-κB signaling
Authors: Mao Fangli , Wu Aiping
Published: July 2022

Polyphyllin I is an active steroidal saponin isolated from Paris polyphylla with anti-cancer and anti-inflammatory properties. The present study investigates the role of polyphyllin I in acute lung injury. Firstly, the human bronchial epithelial cells (BEAS-2B) and human pulmonary artery endothelial cells (HPAEC) were stimulated with increasing concentrations of lipopolysaccharide at 2, 5, and 10 μg/mL. The treatment with lipopolysaccharide reduced the cell viabilities of BEAS-2B and HPAEC, downregulated superoxide dismutase (SOD) and glutathione (GSH), and up-regulated myeloperoxidase (MPO) and malondialdehyde (MDA). Moreover, the levels of TNF-α, IL-1β, and IL-6 were also up-regulated in lipopolysaccharide-treated BEAS-2B/HPAEC cells. Secondly, the lipopolysaccharide-treated cells were then incubated with different concentrations of polyphyllin I. Incubation with polyphyllin I enhanced the cell viabilities of lipopolysaccharide--treated BEAS-2B/HPAEC, up-regulated levels of SOD and GSH, and reduced MPO and MDA. Moreover, polyphyllin I reduced TNF-α, IL-1β, and IL-6 in lipopolysaccharide-treated BEAS-2B/HPAEC cells. Thirdly, the up-regulation of GSDMD-N, pro-caspase-1, and cleaved caspase-1 proteins in lipopolysaccharide-treated BEAS-2B/HPAEC cells were decreased by polyphyllin I. Polyphyllin I increased the protein expression of GSDMD-D in the lipopolysaccharide-treated BEAS-2B/HPAEC cells, and inhibited the translocation of GSDMD from cytoplasm to plasma membrane. Lastly, polyphyllin I reduced the expression of p-p65 in lipopolysaccharide-treated BEAS-2B/HPAEC cells. The over-expression of p65 counteracted with the inhibitory effects of polyphyllin I on oxidative stress and inflammation in lipopolysaccharide-treated BEAS-2B. In conclusion, polyphyllin I repressed the lipopolysaccharide-induced oxidative stress and inflammation in BEAS-2B and HPAEC, and reduced pyroptosis through inhibition of NF-κB signaling.
Diagnosis of primary immunodeficiency diseases in pediatric patients hospitalized for recurrent, severe, or unusual infections
Authors: Nepesov Serdar , Firtina Sinem , Aygun Fatma Deniz , Burtenece Nihan , Cokugras Haluk , Camcioglu Yildiz
Published: July 2022

Background: Primary immunodeficiency diseases (PID) usually presents itself with recurrent, severe, and unusual infections, along with autoimmunity and various other malignancies. But, the diversity of PID often makes the diagnosis of patients difficult for physicians other than clinical immunologists. This study aimed to describe the characteristics of patients diagnosed with PIDs during the inpatient treatment for infectious diseases, and to highlight the cases in which a PID diagnosis should be considered.
Methods: The clinical, immunological, and molecular features of 81 pediatric patients treated for infectious diseases, who were diagnosed with a PID during hospitalization was retrospectively analyzed. The diagnosis was based on the PID criteria of the International Union of Immunological Societies.
Results: The five main PID sub-types were identified. Predominantly, antibody deficiencies were the most common (61.7%) group. The average delay in diagnosis was 34.6 months, and the positive family history rate was 24.7%, while the consanguineous marriage rate was 45.7%. Around thirty-five (43%) patients were found to have mutated PID-related genes. While lower respiratory tract infections were the most common symptom, a fever of unknown origin was another remarkable diagnosis. Eight (9.9%) patients underwent allogeneic hematopoietic stem cell transplantation.
Conclusions: Clinicians should consider a PID diagnosis, especially in the cases of recurrent, severe, or atypical infections. Increased knowledge of the alarm features of PID can promote early diagnosis.
JNJ0966 inhibits PDGF-BB-induced airway smooth muscle cell proliferation and extracellular matrix production by regulating MMP-9
Authors: Zhang Yingying , Yao Fan , Qin Zhihua
Published: July 2022

The increased proliferation and extracellular matrix (ECM) production of airway smooth muscle cells (ASMCs) are crucial factors in asthma progression. JNJ0966, one of the metalloproteinase-9 (MMP-9)-specific inhibitors, has been demonstrated to be involved in the progression and development of diversified diseases. Nevertheless, the function of JNJ0966 in ASMCs remains unclear. This study aimed at investigating the effects of JNJ0966 on asthma progression. In our study, the platelet-derived growth factor BB (PDGF-BB) was first utilized to stimulate the cell model for asthma. Results demonstrated that the cell viability of ASMCs was increased by PDGF-BB (0, 10, 20, and 30 ng/mL) in a dose-dependent manner. Further investigation revealed that JNJ0966 inhibited the cell activity and migration ability of PDGF-BB-induced ASMCs. In addition, JNJ0966 relieved ECM deposition in PDGF-BB-induced ASMCs. Finally, through rescue assays, the results showed that overexpression of MMP-9 reversed the inhibitory effects of JNJ0966 on cell viability and ECM deposition in ASMCs. In conclusion, our findings suggested that JNJ0966 inhibited PDGF-BB-induced ASMC proliferation and ECM production by modulating MMP-9. These findings might provide novel insight for the treatment of asthma.
CITED2 alleviates lipopolysaccharide-induced inflammation and pyroptosis in - human lung fibroblast by inhibition of NF-κB pathway
Authors: Zhang Xuzhong , Chen Wei , Liu Wei , Li Donge , Shen Wei
Published: July 2022

Background: Pneumonia, a severe infectious respiratory disease, is one of the leading causes of mortality and morbidity in children. Cbp/P300 interacting transactivator with Glu/Asp-rich carboxy-terminal domain 2 (CITED2) functions as a transcription cofactor, and plays critical roles in the development of embryonic and extra-embryonic tissues, including fetal lung maturation. The present study investigates the role of CITED2 in infantile pneumonia.
Methods: The human fetal lung fibroblasts (MRC-5 and WI-38) were treated with lipopolysaccharides to induce cytotoxicity, and the cell viability was detected by MTT. Inflammation was evaluated by ELISA, and western blot was used to investigate the pyroptosis.
Results: CITED2 was down-regulated in lipopolysaccharide-treated MRC-5/WI-38 cells. The over-expression of CITED2 protected MRC-5 and WI-38 cells from lipopolysaccharide--induced cytotoxicity by increasing the cell viability and decreasing LDH expression. CITED2 reduced the expression of TNF-α, IL-6, IL-1β in lipopolysaccharide-treated MRC-5/WI-38 cells. Lipopolysaccharide stimulated pyroptosis in MRC-5 and WI-38 cells through the up-regulation of NL+RP3, GSDMD-N, caspase-1, IL-1β and IL-18. However, CITED2 down-regulated the expression of NLRP3, GSDMD-N, caspase-1, IL-1β, and IL-18 protein in lipopolysaccharide-treated MRC-5/WI-38 cells. CITED2 also down-regulated the protein expression of p-p65 in lipopolysaccharide--treated MRC-5/WI-38 cells.
Conclusion: CITED2 exhibited anti-inflammatory effect on lipopolysaccharide-treated human lung fibroblasts and reduced pyroptosis through inactivation of NF-κB pathway.
Automatic earthquake detection and phase picking in Muong Te, Lai Chau region: an application of machine learning in observational seismology in Vietnam
Authors: Nguyen Cong Nghia , Nguyen Van Duong , Ha Thi Giang , Dinh Quoc Van , Nguyen Le Minh , Huang Bor-Shouh , Pham The Truyen , Nguyen Tien Hung , Le Quang Khoi , Nguyen Huu Hung
Published: July 2022

We applied the automatic detection and picking of P- and S-wave to one-year continuous raw seismic data from 17 seismic stations in the Muong Te area, northwestern Vietnam. The deep learning picker, Earthquake Transformer, has performed automatic picking of P- and S-waves, and phase association, then we located the earthquakes using Hypoinverse and NonLinLoc programs. The newly derived catalog consisted of 893 events, which is significantly higher than the number of events in the manual catalog. From this new catalog, we can observe more earthquakes related to the Muong Te ML 4.9 earthquake on June 16, 2020, and the earthquake activity in other faults such as the Dien Bien Phu and Muong Nhe faults. The extended catalog can further study the seismogenesis and the seismic velocity structure of the crust beneath northwestern Vietnam.
A Rare Variant of Mazabraud’s Syndrome Overlapping with McCune-Albright Syndrome with a Clinical Review: A Case Report
Authors: Lee Da Woon , Kwak Si Hyun , Jang Si-Hyong , Choi Hwan Jun , Kim Jun Hyuk
Published: July 2022

Mazabraud syndrome (MS) is a rare and sporadic disorder. It is mainly characterized by fibrous dysplasia (FD) of single or multiple bones and intramuscular myxomas (IM). Data on the prevalence since it was first reported, clinical features, and prognosis are extremely scarce. We report a case of a 59-year-old woman with IM and polyostotic FD. She also had multiple cafe’-au-lait spots suggestive of McCune-Albright syndrome (MAS). On magnetic resonance imaging, there are masses with well-defined heterogeneous enhancement, accompanied by an inner cyst in the vastus lateralis muscle and femur. These radiological results are identical to those of FD. After surgical intervention with excision of intramuscular soft-tissue mass, a diagnosis of IM of MS was confirmed. Given that cafe’-au-lait spots also appeared, the patient was diagnosed with a variant of MS with some of the clinical characteristics of MAS.
Idiopathic Omental Infarction to Be a Rare Cause of Acute Abdomen: A Case Report
Authors: Song Geum Jong
Published: July 2022

Omental infarction is a rare entity, representing hemorrhagic omental necrosis as a result of impaired omental perfusion. It can occur secondary to omental torsion or to inflammatory and neoplastic infiltration of the omental segment from adjacent organs. If the foregoing reasons can be excluded, omental infarction is called primary or idiopathic omental infarction. Occlusions of small omental arteries are rare and may be found in patients with thromboembolic disease, arteriolosclerosis, arteritis, or amyloidosis. The author presents a case of idiopathic omental infarction in a 66-year-old male presenting with abdominal pain. The patients underwent an emergent operation and recovered without any complication after surgery.
Primary Diffuse B-cell Lymphoma of Uterine Cervix: A Case Report
Authors: Choi Haeryung , Kim Haemin , Kim Jongsoo
Published: July 2022

Primary diffuse large B-cell lymphoma (DLBCL) of the female genital tract is a rare case. It is hard to diagnose DLBCL of the uterine cervix before surgery because it is often misdiagnosed as cervical myoma or cervical squamous cell carcinoma. Here, we report a case of cervical DLBCL misdiagnosed as a cervical myoma. A 48-year-old premenopausal woman was referred to the gynecology department due to abnormal uterine bleeding with a normal Papanicolaou smear. The initial diagnosis according to ultrasound and computed tomography was a cervical myoma. She had undergone a hysterectomy with bilateral salpingectomy. The final diagnosis was cervical DLBCL and she was referred to the department of hematology for treatment with Rituximab combined chemotherapy. After six courses of chemotherapy, complete remission was reached. At a 2-year follow-up, the patient is alive without interval change.
Relief of Symptoms by Early Administration of Infliximab in Patients with Suspected Spondyloarthritis: A Case Report
Authors: Lee Hyun Keun , Chung Ji Won
Published: July 2022

Low back pain is one of the most common musculoskeletal symptoms, and it can be difficult to make an accurate diagnosis based on symptoms alone. Osteitis condensans ilii (OCI) is one of the benign etiologies of low back pain and buttock pain mainly in young multiparous women. It can be diagnosed by radiological findings of the triangular sclerotic bone lesion, in the bilateral iliac bone of sacroiliac joints. Spondyloarthritis is a group of chronic inflammatory rheumatic diseases with common features, including axial and peripheral inflammatory arthritis, enthesitis, and an association with the human leukocyte antigen B27. Since both diseases may have similar clinical symptoms, the differential diagnosis may be difficult. We present a case of relief of symptoms by administration of infliximab in patients with suspected early spondyloarthritis that may be confused with OCI.
Means of Musical Dialogues and Reciprocity
Authors: Vlachová Zuzana
Published: July 2022

This study investigates improvisational music therapy (IMT) and its influence on the social interaction (SI) of a preschool child with autism spectrum disorder (ASD) in the Czech Republic. This case study tests the use of music therapy as an augmentative intervention for children with ASD. Using a qualitative design and incorporating microanalysis, the aim was to apply methodological protocols of direct and indirect observation on individual IMT sessions. Three SI domains were assessed using microanalysis in this single case study research: a) nonverbal communication, b) sharing, and c) solace. Varied musical features elicited certain intentional behaviors, allowing the interpretation of their meanings. The nonverbal communication studied shows intention to relate, self-awareness, awareness of others, and sharing. The IMT context provides a unique space for dialogues and reciprocity in a protected and settled environment. Children’s improved SI can provide insight into their ability to interact with others. IMT presents promising care for children with ASD, extending comprehensive care by including dimensions of individualization and an intrinsic, non-directive approach, allowing the child to acquire and further develop their own ways of expression for the regulation of SI. Ideas around the quality of SI within IMT need to be further investigated.
Harmonizing Hearts with Many Voices – Analysis of Koolulam, a Mass-Singing Phenomenon, and its Contribution to Resiliency
Authors: Wiess Chava , Maor Rotem
Published: July 2022

Koolulam is a social musical initiative launched in 2017. The aim of Koolulam is to strengthen the fabric of society through mass singing - collaborative singing in large groups. This is the first study worldwide that examines this social musical phenomenon. The aim of the study to examine the profile of people who participate in Koolulam events and their motives for partaking in such an event, and to examine whether the social, communal and emotional characteristics of mass singing such as in a Koolulam event, include elements that may help strengthen the resilience of individuals in a group.  This study used a mixed method approach, combining quantitative and qualitative techniques. The data were collected through questionnaires answered by 914 participants. The findings indicate that Koolulam events are perceived as a unique phenomenon, different from other multi-participant events. The shared singing experience at these events has social, communal and emotional characteristics.

Conclusions: The study shows that singing even one song in a large group consisting of a combination of different voice types, fosters harmony and tolerance among the different voices in the group.
A Perspective on the Development of Itinerant Education for Students with Special Needs: Revisiting the Concept of Itinerant Education and Analyzing 2021 Special Education Statistics
Authors:   The Korean Society of Special Education, Kim Jiyeon
Published: July 2022

The study’s purpose is to revisit the concept of itinerant education at a time of rapid legal and administrative changes regarding itinerant education; furthermore, it will explore and analyze the current state of itinerant education within Korea and suggest developmental plans for it based on the results of this study. Data were collected through related research and laws, and from the 2021 special education statistics. The study results are as follows. First, itinerant education was interpreted from the perspective of educational placement and support for students with special needs based on the concept of the least restrictive environment. The continuous alternative placement model of Korea was suggested. Based on this model, Korean itinerant education was conceptualized; in addition, the concept was divided into ‘itinerant education for schools not assigned with special education teachers’ and ‘home-based itinerant education.’ Second, 5.88% of students with special needs were receiving itinerant education services according to the 2021 Special Education Statistics. The characteristics of these students were confirmed by dividing them into ‘educational placement’ and ‘itinerant education provider. In addition, the characteristics of 17 metropolitan and provincial education offices were suggested. Based on the results of this study, the development of the itinerant education in Korea was discussed in terms of 'revisiting both the concept and terminology of itinerant education,' 'preparation of the itinerant education system that reflects school-level specificity,’ 'operating a differentiated itinerant education system that reflects the specialties of metropolitan/provincial educational offices,' and 'establishing the role of special education support centers and their teachers.’ Finally, the limitations and suggestions of these discussions for future studies were discussed.
The Current Status of Diagnosis and Evaluation and Demand for Support of Special Education Support Centers for Children from Multicultural Families: Focusing on the Seoul Metropolitan Area
Authors:   The Korean Society of Special Education, Jeong Joohee , Jung Pyung-Gang
Published: July 2022

The purpose of this study is to investigate the current status of diagnosis, evaluation process, and demands of the Special Education Support Center (SESC) for personnel who have experience in diagnosing and evaluating children from multicultural families. To this end, questionnaires were developed and distributed online to the personnel at the SESC; a total of 39 answers were collected. The results of this analysis are as follows. First, the diagnostic evaluation process has been conducted as an individual effort of the personnel without specific guidelines and standards to identify children from multicultural families. However, resources and supports were insufficient across all aspects; this included collecting various pre-referral information, supporting active parent participation, determining dominant languages, composing a multidisciplinary team, and building the personnel’s expertise in the diagnostic evaluation process. Second, the personnel had difficulties dealing with communication with multicultural families; furthermore, they pointed out a problem to refer the children from multicultural families to SESC without any efforts to implement pre-referral intervention. In addition, it was difficult to compose a multidisciplinary team including multicultural experts due to a lack of recognition regarding the importance of the team for children of multicultural families. Third, the personnel requested supports for effective communication with multicultural families; additionally, they wanted legal basis, specific guidelines, and systematic pre-referral intervention systems. The personnel requested professional development programs about children with disabilities from multicultural families; including programs that combine theoretical and practical knowledge, as well as a collaboration system between SESC and multicultural-related institutions to support reliable diagnosis and evaluation of children from multicultural families. Based on these results, practical implications and future research were discussed.
The Effect of Augmented Reality-Based Teaching During Free Play on Changes in Mean length of utterance and Communication Function of Children with Moderate Physical Disabilities
Authors:   The Korean Society of Special Education, Park Chanwoo
Published: July 2022

The purpose of this study is to investigate the effect Augmented Reality-based teaching in free play has on both the average length of spontaneous speech and changes in communication function regarding children with moderate physical disabilities. The subject of this study was a five-year-old child with moderate physical disabilities. The research method was designed as a baseline, intervention, generalization, and maintenance phase by designing a medium-to-multiple intermittent baseline between situations. The intervention strategy was mediated by AR based teaching that applied sensory information, action induction, context maintenance, and recognition. The results of this study are as follows: First, the average utterance length of children with severe physical disabilities increased through AR-based instruction in the free play scenario; and second the communication function of children with severe physical disabilities has been diversified through AR-based teaching in the free play scenario. This study is meaningful in that it had a positive effect on the development of spontaneous speech and communication skills in children with moderate physical disabilities; all accomplished through AR-based teaching with in a play situation.
Family implications during deprivation of liberty and Attachment Theory: a qualitative metasynthesis
Authors: Gato Caroline Menzel , Nascimento Lucila Castanheira , Simoneti Rafaela Azevedo Abrantes de Oliveira , Massaroli Aline , Silva Sílvio Éder Dias da , Araújo Jeferson Santos
Published: July 2022

ABSTRACT Objectives: to synthesize evidence from qualitative studies about the implications that the deprivation of liberty process has on incarcerated adults’ family relationships. Methods: a qualitative meta-synthesis, carried out in January 2021, by searching for publications indexed in six databases. The sample consisted of 10 studies, which were analyzed by MaxQDA®, and an interpretative synthesis was performed based on Attachment Theory. Results: based on first-order concepts, it was possible to synthesize second- and third-order concepts and present them in two interpretive context units: Strategies for strengthening family ties; Relationships that contribute to breaking down family ties. It was evidenced that visits, phone calls and letters favor the strengthening of secure attachment. Final Considerations: incarceration causes consequences in tie formation, reflecting on the attachment process between family members.
Can we use Ki67 expression to predict prostate cancer aggressiveness?
Authors: MAIA RONALDO , SANTOS GABRIEL ARANTES DOS , REIS SABRINA , VIANA NAYARA I , PIMENTA RUAN , GUIMARÃES VANESSA R , RECUERO SAULO , ROMÃO POLIANA , LEITE KATIA RAMOS MOREIRA , SROUGI MIGUEL , PASSEROTTI CARLO CARMARGO
Published: July 2022

ABSTRACT Introduction: specialists have an urge for biomarkers that can discriminate indolent prostate cancer from aggressive tumors. Ki67 is a proliferation marker, and its expression is associated with the aggressiveness of several cancers. Objective: analyze the expression of Ki67 in prostate cancer samples correlating with the aggressiveness of the disease. Methods: Ki67 mRNA levels were determined utilizing data from a TCGA cohort (Tumor(n)=492 and control(n)=52). The protein expression was determined on 94 biopsies from patients by immunohistochemical assay. Results: in mRNA, the Ki67 upregulation is associated with cancer tissue (p<0.0001) and worst disease-free survival (p=0.035). The protein upregulation is associated with increase of the ISUP score (p<0.0001), cancer stage (p=0.05), biochemical recurrence (p=0.0006) and metastasis (p<0.0001). We also show a positive correlation between Ki67 expression and ISUP score (r=0.5112, p<0.0001) and disease risk stratification (r=0.3388, p=0.0009). Ki67 expression is a factor independently associated with biochemical recurrence (p=0.002) and metastasis (p<0.0001). Finally, the patients with high Ki67expression shows better survival regarding biochemical recurrence (p=0.008) and metastasis (p=0.056). Patients with high Ki67 expression are 2.62 times more likely to develop biochemical recurrence (p=0.036). Conclusion: Ki67 upregulation is associated with prostate cancer aggressiveness.
Uma alternativa de interpretação do II PND
Authors: AGUIRRE BASÍLIA MARIA BAPTISTA , SADDI FABIANA DA CUNHA
Published: July 2022

RESUMO Este artigo tem como objetivo apresentar uma interpretação alternativa da lógica de concepção e implementação do II PND. Utiliza a contribuição de Weber e de outros autores que desenvolveram o conceito de patrimonialismo para melhor compreender a forma como o Estado brasileiro conduziu esse projeto. Destaca que o plano não se pautou exclusivamente por uma lógica econômica, mas também por razões políticas.
Uma proposta de unificação monetária dos países do Mercosul
Authors: GIAMBIAGI FABIO
Published: July 2022

RESUMO Este artigo trata do possível fortalecimento futuro da integração econômica entre os países do Mercosul, semelhante à integração europeia relacionada ao acordo de Maastricht. São apresentados alguns dos problemas associados à coordenação das políticas macroeconômicas e à unificação monetária e defende-se a viabilidade de um acordo semelhante ao de Maastricht entre os membros do Mercosul. Por fim, é feita uma proposta de cronograma - a ser anunciado em 2002 e ocorrer no ano de 2012 - para se conseguir uma integração monetária entre Brasil, Argentina, Uruguai, Paraguai e eventualmente outros países.
Uso das Tecnologias da Informação e Comunicação (TDIC) como Recursos Pedagógicos para o Ensino de Climatologia: Estudo de caso na Região Metropolitana de Fortaleza, CE
Authors: Silva Emerson Mariano da , Silva Francisco Bruno Santana da , Araújo Leonardo Manuel de Morais , Silva Lindenberg Lucena da , Barbosa Wellington Antonio
Published: July 2022

Resumo Nesse estudo apresentam-se os resultados obtidos de uma pesquisa realizada com professores de escolas públicas localizadas na Região Metropolitana de Fortaleza, CE (RMF) pertencentes a Secretaria Municipal de Educação, Ciência e Tecnologia - SMECT do município de Caucaia/CE sobre o uso das TDIC nas aulas de climatologia no ensino fundamental. Em adição, apresentam-se os resultados do uso das técnicas de Sensoriamento Remoto (SR) como método pedagógico nas aulas de climatologia nas turmas do terceiro ano do ensino médio. Os resultados mostraram o uso incipiente das TDIC como tecnologia educacional apesar do reconhecimento dos benefícios que essas ferramentas proporcionam no ensino de climatologia além da necessidade de um programa de formação continuada para os professores que atuam nessa faixa etária. A aplicação das técnicas de SR no estudo de ilhas de calor mostraram que essa metodologia representa um grande potencial como recurso didático e que facilitou a compreensão da formação desse fenômeno e seus efeitos no clima, na saúde e no bem-estar das comunidades que vivem nessas áreas além de auxiliar os estudantes na resolução das questões do Exame Nacional do Ensino Médio (ENEM).
Correlação Entre a Exatidão da Medida de Posição do GPS e as Condições Atmosféricas
Authors: Saraiva Matheus Duarte , Sousa Gerbison Ferreira de , Marreira Rubens Damiglê Alves , Pinheiro Francisco Geraldo de Melo
Published: July 2022

Resumo O Global Positioning System (GPS) é capaz de calcular a posição de um receptor na superfície do Planeta Terra ou próxima a este. Contudo, como todo sistema de medição, o GPS está sujeito a erros. São muitas as causas destes erros. Um destes é a dinâmica da refração atmosférica. Esta é composta por diversas camadas, com estruturas e comportamentos particulares. Se o índice de refração de cada camada fosse constante, isto não seria um problema. Ocorre que a dinâmica da atmosfera torna o índice de refração instável. Usuários comuns já perceberam claramente que, em dia de chuva, é comum que seus aplicativos de localização apresentem falhas nesta localização. Este trabalho apresenta a relação da exatidão de um GPS com as condições atmosféricas em especial eventos de chuva. Para tanto, foram utilizados dados de um receptor GPS e dados da atmosfera. Os resultados apresentados neste trabalho demostram que durante eventos de chuva a exatidão do GPS fica comprometida.
The effect of the dark triad traits on the relationship between obedience pressure and budgetary slack,
Authors: Nottar Daiane Inacio da Silva , Schiavo Priscila dos Santos , Vesco Delci Grapégia Dal , Santos Cleston Alexandre dos
Published: July 2022

ABSTRACT The aim of this paper was to evaluate the effect of personality traits on the relationship between obedience pressure and the creation of budgetary slack. Concatenating the dark triad personality traits and obedience pressure in a decision-making scenario relating to the creation of budgetary slack enables us to widen the investigation of factors associated with the practicing of budgetary slack. The relevance of this study lies in understanding how personality traits influence decision making under hierarchical obedience pressure in relation to the creation of budgetary slack, enabling us to measure and detect possible biases in managers’ decision making due to these factors, thus being able to predict or mitigate decisions in the organizational environment. It was verified that the practice of creating budgetary slack can be carried out independently of a hierarchical order and that personality traits influence decision making with relation to the execution and planning of budgets. The article makes theoretical contributions to the accounting area, enabling the advancement and deepening of the discussion of social aspects (obedience theory) and behavioral aspects (personality traits) associated with decision making relating to the creation of budgetary slack. The approach is quantitative and experimental (2 x 2 factorial design), using 82 accounting sciences students. The data were analyzed using Mann-Whitney and Kruskal-Wallis tests and binary logistic regression. It was found that, independently of being under obedience pressure, individuals with high dark triad personality traits were more inclined toward the creation of budgetary slack, demonstrating that the intrinsic personality traits of each individual have an effect over decision making. However, regarding obedience pressure, it was verified that there was no significant effect on the creation of budgetary slack. These results offer contributions to organizations, as their managers and teams do not practice slack due to obedience pressure scenarios, but rather according to personality traits.
Network care: relationship between prenatal care adequacy and hospital obstetric care in a cross-sectional study
Authors: Ferreira Fernanda Marçal , Venâncio Kelly Cristina Máxima Pereira , Narchi Nádia Zanon
Published: July 2022

ABSTRACT Objective: To assess the relationship between prenatal care adequacy and the demand for hospital obstetric care. Method: A cross-sectional, quantitative study, conducted in a Brazilian capital, at six basic units and a hospital unit, from 2017 to 2020. Pregnant women who met the predefined inclusion and exclusion criteria participated in the study. Data were collected by structured questionnaire, and follow-up of participants was in person, by phone and by application. Descriptive and analytical statistics were performed using a statistical program. Results: A total of 224 women were investigated. Prenatal care was adequate in 42.4% of cases, and the mean percentage of adequacy was 76.7% of assessed indicators. Of the 1,067 hospital visits, 63.1% were inopportune. The regression model showed that the variable “prenatal care adequacy” was statistically relevant (0.043), with a 2.2 times higher Odds Ratio (OR) of women who had inadequate prenatal follow-up seeking the hospital inanely. Conclusion: Prenatal care inadequacy was related to the inopportune search for emergency room care, with care overload for this point in the care network.
LIVING WITH PREGNANCY-ASSOCIATED CANCER: GROUNDED THEORY BASED ON FAMILY EXPERIENCES
Authors: Gomes Joseila Sonego , Sand Isabel Cristina Pacheco Van der , Girardon-Perlini Nara Marilene Oliveira
Published: July 2022

ABSTRACT Objective: to understand the experience of families living with pregnancy-associated cancer. Method: grounded theory with symbolic interactionism as a theoretical reference. Twelve families with a woman diagnosed with pregnancy-associated cancer participated in the study. Data were collected by identification form, genogram and interview, between March 2018 and March 2019, and the analysis followed the stages of substantive and theoretical coding. Results: the constant comparative analysis of the data developed the substantive theory "Living between weaknesses and motivations: experiences of families with pregnancy-associated cancer" explaining the experience with the central concept "Living between losses that weaken and the arrival of the child who strengthens", which represents the symbolic actions and strategies of the family that perceives itself in a condition of duality. Conclusion: throughout the experience, the family moves from a condition in which illness is identified as a difficulty for the experience of pregnancy and birth to another in which pregnancy and birth are seen as motivators for cancer treatment.
A Neoinstitutionalist Proposal to Study the BRICS
Authors: Guerrero Mario Guillermo
Published: July 2022

Abstract This article seeks to contribute to the current disciplinary discussion about the BRICS from a neoinstitutionalist perspective. Here, we understand BRICS as an international institution which has deepened its technical-bureaucratic dynamics after the trust effect that was created from coordination and consistency experiences around aspects of the international economic agenda during the 2008/2009 economic-financial crisis. Therefore, our analytical proposal approaches the BRICS from its three institutional elements: its deliberation spaces; its information system; and its institutional incentive system. In summary, we consider that the proposed approach will allow us to understand in greater detail what institutional factors and features affect the probability of reaching consensus and cooperation among the BRICS member countries, as well as to identify in greater detail the institutional particularities that differentiate the BRICS from similar institutional experiences.
EVALUATION AND COMPREHENSIVE COMPARISON OF OCTADECYLAMINE AND STEARAMIDE-BASED SOLID LIPID NANOPARTICLES FOR EFFICIENT GENE DELIVERY
Authors: Kirmizitaş Fatma Ceren , Varlı Hanife Sevgi , Türkoglu Nelisa
Published: July 2022

In recent years various nonviral vector systems have been developed to overcome the disadvantages of viral vectors. Thus, researchers have turned to more secure and easy to reach vector systems. In this study, we have evaluated the gene transfer efficiency of two different nonviral vectors prepared using two lipids: octadecylamine and stearamide. The solid lipid nanoparticles were produced with the emulsion-solvent evaporation method. Particles' mean size, polydispersity index (PDI), and zeta potential values for octadecylamine nanoparticle (ONP) are, respectively, 382.7 nm (± 20), 0.4, and 28 mV (±

2.03) and for stearamide nanoparticle (SNP) are 276.9 nm (± 10.45), 0.3, and 20.4 mV (± 4.03), as determined by using Zetasizer via the dynamic light scattering (DLS) method. Morphological characterization of nanoparticles was performed with scanning electron microscope (SEM) and atomic force microscope (AFM). The chemical characterization was performed by Fourier-transform infrared spectroscopy (FTIR). The cytotoxicity of nanoparticles were determined via 3-(4,5-Dimethylthiazol)-2,5-diphenyltetrazolium bromide (MTT) assay with an MCF-7 human breast cancer cell line. The cytotoxicity for both ONP and SNP were calculated over 55%. Also nanoparticles/plasmid DNA conjugates cytotoxicity were determined with no significant toxicity obtained. The transfection efficiency was evaluated by observing green fluorescent protein (GFP) expression in the MCF-7 human breast cancer cell line. The transfection efficiency was 67.5% (± 2.3) for ONP, 77.6% (± 1.2) for SNP, and 70.7% (± 1.4) for commercially available transfection agent.