bluuebunny/crossref_metadata_2025 huggingface dataset:
Performance Evaluation of Cementitious Composites Incorporating Nano Graphite Platelets as Additive Carbon Material
Authors: Ahmad Farhan , Jamal Arshad , Iqbal Mudassir , Alqurashi Muwaffaq , Almoshaogeh Meshal , Al-Ahmadi Hassan M. , E. Hussein Enas
Published: January 2022

Nano graphite platelets (NGPs) belong to the carbon family and have a huge impact on the construction industry. NGPs are used as multi-functional fillers and have the potential to develop reinforcing within cementitious composites. In this paper, NGPs were incorporated in cementitious composites to investigate the effects of NGPs on the fresh, mechanical, durability, and microstructural properties of concrete. Five mixes were prepared with intrusion of NGPs (0%, 0.5%, 1.5%, 3%, and 5% by weight of cement). The properties studied involved workability, air content, hardened density, compressive strength, tensile strength, flexural strength, sorptivity, ultrasonic pulse velocity (UPV), water absorption, and external sulfate attack. The workability and percent air content decrease by 22.5% and 33.8%, respectively, for concrete with 5% NGPs compared to the control mix. The specimens containing 5% of NGPs revealed the hardened density, compressive, tensile, and flexural strength to increase by 11.4%, 38.5%, 31.6%, and 44.34%, respectively, compared to the control mix. The results revealed that the incorporation of 5%NGPs in cementitious composites reduces the sorptivity and water absorption by 32.2% and 73.9%, respectively, whereas, it increases the UPV value by 7.5% compared to the control mix. Furthermore, the incorporation of NGPs provided better resistance against external sulfate attacks. SEM–EDX spectroscopy was carried out to investigate its microstructural analysis.
Experimental and Numerical Investigation of Bond-Slip Behavior of High-Strength Reinforced Concrete at Service Load
Authors: Dey Alinda , Valiukas Domas , Jakubovskis Ronaldas , Sokolov Aleksandr , Kaklauskas Gintaris
Published: January 2022

A bond mechanism at the reinforcement-concrete interface is one of the key sources of the comprehensive functioning of reinforced concrete (RC) structures. In order to apprehend the bond mechanism, the study on bond stress and slip relation (henceforth referred as bond-slip) is necessary. On this subject, experimental and numerical investigations were performed on short RC tensile specimens. A double pull-out test with pre-installed electrical strain gauge sensors inside the modified embedded rebar was performed in the experimental part. Numerically, a three dimensional rib scale model was designed and finite element analysis was performed. The compatibility and reliability of the numerical model was verified by comparing its strain result with an experimentally obtained one. Afterwards, based on stress transfer approach, the bond-slip relations were calculated from the extracted strain results. The maximum disparity between experimental and numerical investigation was found as 19.5% in case of strain data and 7% for the bond-slip relation at the highest load level (110 kN). Moreover, the bond-slip curves at different load levels were compared with the bond-slip model established in CEB-fib Model Code 2010 (MC2010). Overall, in the present study, strain monitoring through the experimental tool and finite element modelling have accomplished a broader picture of the bond mechanism at the reinforcement-concrete interface through their bond-slip relationship.
Analysing the Interaction between Microscopic Deformation, Microstructure and Void Evolution of Near-α Titanium Alloys during Non-Superplastic Hot Deformation by an Integrated Crystal Plasticity Finite Element Model
Authors: Zhao Jie , Wang Kehuan , Lv Liangxing , Wang Liliang , Politis Denis J. , Liu Gang
Published: January 2022

High-efficiency and low-cost hot forming technologies for titanium alloys have been developed for producing complex-shaped, thin-walled tubular components under non-superplastic forming conditions. Under these forming conditions, there exist complex and highly integrated material evolution processes including microscopic heterogeneous deformation, microstructure evolution and damage behaviour. This paper presents an integrated crystal plasticity finite element model of near-α titanium alloys during non-superplastic hot deformation conditions considering grain boundary sliding (GBS), dynamic recrystallisation (DRX), as well as void evolution. The polycrystalline model of a near-α TA15 titanium alloy was established, containing α phase, β phase and grain boundary (GB) regions, in which the GB region was a visualised representation of GBS. The quantitative strength ratio between the GB regions and α phase was calculated according to the Zener–Holloman parameter Z and grain size, which determined the microscopic deformation behaviour. There were found to be two high microscopic strain regions in the α phase: intragranular deformation bands through the most favourable slipping and near the GBs through multiple slipping, which promoted continuous and discontinuous DRX, respectively. With the decrease in parameter Z or grain size, the activated dislocations accommodating GBS were found to no longer pile up inside the grain, but instead travel across the grain interior. Finally, methods to improve the macroscopic plastic formability were proposed for the difficult-to-form titanium alloys experiencing non-superplastic hot deformation.
Mesenchymal Stem Cell Senescence and Osteogenesis
Authors: Tjempakasari Artaria , Suroto Heri , Santoso Djoko
Published: January 2022

Mesenchymal stem cells (MSCs) are stem cells with the potential ability to differentiate into various cells and the ability to self-renew and resemble fibroblasts. These cells can adhere to plastic to facilitate the culture process. MSCs can be used in research into tissue biotechnology and rejuvenation medicine. MSCs are also beneficial in recipient tissue and differentiate as a breakthrough strategy through paracrine activity. Many databases have shown MSC-based treatment can be beneficial in the reduction of osteogenesis induced by senescence. In this article, we will discuss the potential effect of MSCs in senescence cells related to osteogenesis.
Effect of Clinical Inertia on Diabetes Complications among Individuals with Type 2 Diabetes: A Retrospective Cohort Study
Authors: Kaewbut Piranee , Kosachunhanun Natapong , Phrommintikul Arintaya , Chinwong Dujrudee , Hall John J , Chinwong Surarong
Published: January 2022

Background and Objectives: Clinical inertia is a key obstacle that leads to suboptimal care in patients with type 2 diabetes mellitus (T2DM). It can occur at any stage of T2DM treatment. However, the effect of clinical inertia on diabetes complications has not been studied sufficiently. This study aimed to evaluate the effect of clinical inertia on the risk of diabetes complications among patients with T2DM. Materials and Methods: A retrospective cohort study was conducted at a tertiary teaching hospital in Thailand between 2011 and 2017. Outpatients with T2DM, aged 40–65 years, presenting an HbA1c greater than 7% were included in this study. Clinical inertia was identified when patients did not get treatment intensification at the index date and a subsequent prescription. The association between clinical inertia and diabetes complications, including a composite of macrovascular complications and a composite of microvascular complications, was determined using a Cox proportional hazard model. Propensity score methods were applied, to control confounding by indication. Results: Of 686 patients with T2DM, 165 (24.0%) experienced clinical inertia. Baseline low-density lipoprotein cholesterol, blood pressure, body mass index, the estimated glomerular filtration rate, and medication between the two groups did not differ significantly. Our study found that clinical inertia was associated with a significantly increased risk of diabetic nephropathy (adjusted HR 1.51, 95% CI 1.01–2.27). The results remained the same as when using propensity score methods. According to the post hoc analysis, lowering the HbA1c levels by 1% results in a significant decrease in the rate of diabetic complications (adjusted HR 0.92, 95% CI 0.86–0.99), the composite of microvascular complications (adjusted HR 0.91, 95% CI 0.84–0.98) and diabetic nephropathy (adjusted HR 0.89, 95% CI 0.80–0.98). Conclusions: Our results demonstrated a significant effect of clinical inertia on diabetic nephropathy. Patients with an HbA1c level over the target range should have their medication intensified to reduce the risk of diabetic nephropathy.
Water Age Effects on the Occurrence and Concentration of Legionella Species in the Distribution System, Premise Plumbing, and the Cooling Towers
Authors: Logan-Jackson Alshae R. , Rose Joan B.
Published: January 2022

In this study, droplet digital PCRTM (ddPCRTM) was used to characterize total Legionella spp. and five specific Legionella species from source (groundwater) to exposure sites (taps and cooling towers). A total of 42–10 L volume water samples were analyzed during this study: 12 from a reservoir (untreated groundwater and treated water storage tanks), 24 from two buildings (influents and taps), and six from cooling towers, all part of the same water system. The approximate water age (time in the system) for all sample locations are as follows: ~4.5, 3.4, 9.2, 20.8, and 23.2 h (h) for the groundwater to the reservoir influent, reservoir influent to the reservoir effluent, reservoir effluent to building Fa (building names are abbreviated to protect the privacy of site location), building ERC and the cooling towers, respectively. Results demonstrated that gene copies of Legionella spp. (23S rRNA) were significantly higher in the cooling towers and ERC building (p < 0.05) relative to the reservoir and building Fa (closest to reservoir). Legionella spp. (23S rRNA) were found in 100% (42/42) of water samples at concentrations ranging from 2.2 to 4.5 Log10 GC/100 mL. More specifically, L. pneumophila was found in 57% (24/42) of the water samples, followed by L. bozemanii 52% (22/42), L. longbeachae 36% (15/42), L. micdadei 23% (10/42) and L. anisa 21% (9/42) with geometric mean concentrations of 1.7, 1.7, 1.4, 1.6 and 1.7 Log10 GC/100 mL, respectively. Based on this study, it is hypothesized that water age in the distribution system and the premise-plumbing system as well as building management plays a major role in the increase of Legionella spp., (23S rRNA) and the diversity of pathogenic species found as seen in the influent, and at the taps in the ERC building—where the building water quality was most comparable to the industrial cooling towers. Other pathogenic Legionella species besides L.pneumophila are also likely amplifying in the system; thus, it is important to consider other disease relevant species in the whole water supply system—to subsequently control the growth of pathogenic Legionella in the built water environment.
Epigenetic Regulation of Human T-Cell Leukemia Virus Gene Expression
Authors: Ratner Lee
Published: January 2022

Viral and cellular gene expression are regulated by epigenetic alterations, including DNA methylation, histone modifications, nucleosome positioning, and chromatin looping. Human T-cell leukemia virus type 1 (HTLV-1) is a pathogenic retrovirus associated with inflammatory disorders and T-cell lymphoproliferative malignancy. The transforming activity of HTLV-1 is driven by the viral oncoprotein Tax, which acts as a transcriptional activator of the cAMP response element-binding protein (CREB) and nuclear factor kappa B (NFκB) pathways. The epigenetic effects of Tax and the induction of lymphoproliferative malignancy include alterations in DNA methylation and histone modifications. In addition, alterations in nucleosome positioning and DNA looping also occur in HTLV-1-induced malignant cells. A mechanistic definition of these effects will pave the way to new therapies for HTLV-1-associated disorders.
A Pilot Assessment of a ‘Plastic Free Community’ Initiative, Respective Community Actions and Residents’ Behavior
Authors: MacDonald Anna , Allen Deonie , João Elsa
Published: January 2022

The problems of plastic pollution are increasing and have been linked to sustainability efforts. Some communities have tried to tackle this issue by implementing ‘plastic free’ initiatives, such as the ‘Plastic Free Community’. Community initiatives foster change and encourage improved environmental outcomes; however, it is unclear if ‘plastic free’ initiatives have the capacity to ‘snowball’ into further sustainable behaviors or if they are a ‘distraction’ from more pressing environmental issues. This study presents the behavioral changes, snowball and distraction effects from the first Scottish mainland ‘plastic free community’ initiative. The pilot study of ‘Plastic Free Anstruther’ (Scotland) identifies self-transcending values and locus of control as important drivers for change, but adoption of single-use plastic alternatives and a ‘single use’ mindset resulted in a limited ‘snowball’ effect. Future ‘Plastic Free Community’ initiatives should focus on encouraging more circular approaches and individual behavior change to reduce waste and improve environmental outcomes. While the initiative resulted in greater awareness of wider environmental issues, additional incentives for individual and business pro-environmental behavior could further improve economic, social and environmental sustainability.
The Immuno-Modulatory Activities of Pentaherbs Formula on Ovalbumin-Induced Allergic Rhinitis Mice via the Activation of Th1 and Treg Cells and Inhibition of Th2 and Th17 Cells
Authors: Li Peiting , Tsang Miranda Sin-Man , Kan Lea Ling-Yu , Hou Tianheng , Hon Sharon Sze-Man , Chan Ben Chung-Lap , Chu Ida Miu-Ting , Lam Christopher Wai-Kei , Leung Ping-Chung , Wong Chun-Kwok
Published: January 2022

Allergic rhinitis (AR) is a highly prevalent allergic disease induced by immunoglobulin (Ig) E-mediated hypersensitivity reaction at the nasal epithelium against inhaled allergens. Previous studies have demonstrated that Pentaherbs formula (PHF), a modified herbal formula comprising five herbal medicines (Flos Lonicerae, Herba Menthae, Cortex Phellodendri, Cortex Moutan and Rhizoma Atractylodis), could suppress various immune effector cells to exert anti-inflammatory and anti-allergic effects in allergic asthma and atopic dermatitis. The present study aimed to further determine the anti-inflammatory activities of PHF in an ovalbumin (OVA)-induced AR BALB/c mouse model. Nasal symptoms such as sneezing and nose rubbing were recorded and the serum total IgE and OVA-specific IgG1, as well as interleukin (IL)-4, IL-5, IL-10, IL-13, chemokines CXCL9 CXCL10, and tumor necrosis factor (TNF)-α concentrations in nasal lavage fluid (NALF) were measured during different treatments. Effects of PHF on the expression of inflammatory mediators in the sinonasal mucosa were quantified using real-time QPCR. PHF was found to suppress allergic symptoms, infiltration of inflammatory cells, and hyperplasia of goblet cells in the nasal epithelium of the OVA-induced AR mice. PHF could reduce OVA-specific IgG1 level in serum, and TNF-α and IL-10 in nasal lavage fluid (NALF), significantly up-regulate the splenic regulatory T (Treg) cell level, increase the Type 1 helper T cell (Th1)/Type 2 helper T cell (Th2) ratio, and reduce the Th17 cells (all p < 0.05). PHF could also alleviate in situ inflammation in sinonasal mucosa of OVA-induced AR mice. In conclusion, oral treatment of PHF showed immuno-modulatory activities in the OVA-induced AR mice by regulating the splenic T cell population to suppress the nasal allergy symptoms and modulating inflammatory mediators, implicating that PHF could be a therapeutic strategy for allergic rhinitis.
Forensic Analysis and Identification Processes in Mass Disasters: Explosion of Gun Powder in the Fireworks Factory
Authors: Marrone Maricla , Tarantino Francesca , Stellacci Alessandra , Baldassarra Stefania Lonero , Cazzato Gerardo , Vinci Francesco , Dell’Erba Alessandro
Published: January 2022

A mass disaster is a situation that involves criticality between the number of victims and resources, in terms of both men and means, present on the site of an event that is mostly unexpected and sudden. In the multidisciplinary teams that intervene, the role of forensic pathologists, who are responsible for the direction and coordination of post-mortem operations, is central, and must remain so. The authors report the case of an explosion of a pyrotechnic artifice factory, as a result of which numerous victims and injuries are recorded. So, the team completed the autopsies and created a protocol to obtain biological samples (bones, blood, teeth, muscles), while the forensic pathologists contacted the families of the alleged victims and each provided a blood sample that was collected for the DNA. The geneticist, using the method of gene extraction and amplification, obtained the DNA from each bone, tooth, and muscle of blood taken from the victims and then compared it with that extracted from the blood samples of the relatives; the electropherograms showed at least one allele for each genetic marker of the “Combined DNA Index System” in common between the victims and the families, thus allowing to establish the identity of all the subjects involved in the event. Having established the identity of all workers, it was possible to determine their whereabouts in the environment at the time of the location of fires and explosions. The results of the various forensic analyzes (autopsies, genetic investigations and even traumatological investigations) have allowed us to validate a scientific method useful in all mass disasters even when any type of anthropological or forensic dental research is difficult.
Novel Substituted Purine Isosteres: Synthesis, Structure-Activity Relationships and Cytotoxic Activity Evaluation
Authors: Dimitrakis Spyridon , Gavriil Efthymios-Spyridon , Pousias Athanasios , Lougiakis Nikolaos , Marakos Panagiotis , Pouli Nicole , Gioti Katerina , Tenta Roxane
Published: January 2022

A number of pyrrolo[2,3-c]pyridines, pyrrolo[3,2-d]pyrimidines and pyrazolo[4,3-d]pyrimidines were designed and synthesized as antiproliferative agents. The target compounds possessed selected substituents in analogous positions on the central scaffold that allowed the extraction of interesting SARs. The cytotoxic activity of the new derivatives was evaluated against prostatic (PC-3) and colon (HCT116) cell lines, and the most potent analogues showed IC50 values in the nM to low µM range, while they were found to be non-toxic against normal human fibroblasts (WI-38). Flow cytometric analysis of DNA content revealed that the most promising derivative 14b caused a statistically significant accumulation of PC-3 cells at G2/M phase and induced apoptosis in PC-3 cells.
GaN-Based Resonant-Cavity Light-Emitting Diodes Grown on Si
Authors: Chen Wen , Feng Meixin , Tang Yongjun , Wang Jian , Liu Jianxun , Sun Qian , Gao Xumin , Wang Yongjin , Yang Hui
Published: January 2022

GaN-on-Si resonant-cavity light-emitting diodes (RCLEDs) have been successfully fabricated through wafer bonding and Si substrate removal. By combining the chemical mechanical polishing technique, we obtained a roughness of about 0.24 nm for a scan area of 5 μm × 5 μm. The double-sided dielectric distributed Bragg reflectors could form a high-quality optical resonant cavity, and the cavity modes exhibited a linewidth of 1 nm at the peak wavelength of around 405 nm, corresponding to a quality factor of 405. High data transmission in free space with an opening in the eye diagram was exhibited at 150 Mbps, which is limited by the detection system. These results showed that GaN-based RCLEDs grown on Si are promising as a low-cost emitter for visible light communications in future.
The Importance of Glycerophospholipid Production to the Mutualist Symbiosis of Trypanosomatids
Authors: de Azevedo-Martins Allan C. , Ocaña Kary , de Souza Wanderley , Vasconcelos Ana Tereza Ribeiro de , Teixeira Marta M. G. , Camargo Erney P. , Alves João M. P. , Motta Maria Cristina M.
Published: January 2022

The symbiosis in trypanosomatids is a mutualistic relationship characterized by extensive metabolic exchanges between the bacterium and the protozoan. The symbiotic bacterium can complete host essential metabolic pathways, such as those for heme, amino acid, and vitamin production. Experimental assays indicate that the symbiont acquires phospholipids from the host trypanosomatid, especially phosphatidylcholine, which is often present in bacteria that have a close association with eukaryotic cells. In this work, an in-silico study was performed to find genes involved in the glycerophospholipid (GPL) production of Symbiont Harboring Trypanosomatids (SHTs) and their respective bacteria, also extending the search for trypanosomatids that naturally do not have symbionts. Results showed that most genes for GPL synthesis are only present in the SHT. The bacterium has an exclusive sequence related to phosphatidylglycerol production and contains genes for phosphatidic acid production, which may enhance SHT phosphatidic acid production. Phylogenetic data did not indicate gene transfers from the bacterium to the SHT nucleus, proposing that enzymes participating in GPL route have eukaryotic characteristics. Taken together, our data indicate that, differently from other metabolic pathways described so far, the symbiont contributes little to the production of GPLs and acquires most of these molecules from the SHT.
Bacteriome Diversity of Blackflies’ Gut and Association with Onchocerca volvulus, the Causative Agent of Onchocerciasis in Mbam Valley (Center Region, Cameroon)
Authors: Efon Ekangouo Arnauld , Nana Djeunga Hugues C. , Sempere Guilhem , Kamgno Joseph , Njiokou Flobert , Moundipa Fewou Paul , Geiger Anne
Published: January 2022

Vector control using larvicides is the main alternative strategy to address limits of preventive chemotherapy using ivermectin for the control of onchocerciasis. However, it remains substantially limited by implementation difficulties, ecological concerns and the resistance of vector populations. Therefore, efficient and environmentally safe alternative control strategies are still needed. This study explores the composition of the blackfly bacteriome and its variability in the presence of Onchocerca volvulus infection, in order to determine their potential as a novel vector control-based approach to fight onchocerciasis. An entomological survey of a collection of samples was performed in the Bafia health district, a historical endemic focus for onchocerciasis in Cameroon. A total of 1270 blackflies were dissected and the infection rate was 10.1%, indicative of ongoing transmission of onchocerciasis in the surveyed communities. Sequencing process of blackflies’ gut DNA for bacteria screening revealed 14 phyla and 123 genera, highlighting the diversity of gut blackflies bacterial communities. Eight bacteria formed the core of blackfly bacteriome and Wolbachia was the predominant genus with 73.4% of relative abundance of blackflies’ gut bacterial communities. Acidomonas and Roseanomas genera were significantly abundant among infected blackflies (p = 0.01), whereas other genera such as Brevibacterium and Fructobacillus were associated with the absence of infection (p = 0.0009). Differences in gut bacterial distribution of blackflies according to their infection status by the parasite suggest a causal relationship between the bacteriome composition and the onset of blackflies’ infection by O. volvulus or vice versa. Blackfly native bacteria are then potentially involved in infection by O. volvulus, either by facilitating or preventing the parasite infestation of the vector. These bacteria represent an interesting potential as a biological tool/target for a novel approach of vector control to fight onchocerciasis.
GOLT1B Activation in Hepatitis C Virus-Infected Hepatocytes Links ER Trafficking and Viral Replication
Authors: Butterworth Jacqueline , Gregoire Damien , Peter Marion , Roca Suarez Armando Andres , Desandré Guillaume , Simonin Yannick , Virzì Alessia , Zine El Aabidine Amal , Guivarch Marine , Andrau Jean-Christophe , Bertrand Edouard , Assenat Eric , Lupberger Joachim , Hibner Urszula
Published: January 2022

Chronic hepatitis C carries a high risk of development of hepatocellular carcinoma (HCC), triggered by both direct and indirect effects of the virus. We examined cell-autonomous alterations in gene expression profiles associated with hepatitis C viral presence. Highly sensitive single molecule fluorescent in situ hybridization applied to frozen tissue sections of a hepatitis C patient allowed the delineation of clusters of infected hepatocytes. Laser microdissection followed by RNAseq analysis of hepatitis C virus (HCV)-positive and -negative regions from the tumoral and non-tumoral tissues from the same patient revealed HCV-related deregulation of expression of genes in the tumor and in the non-tumoral tissue. However, there was little overlap between both gene sets. Our interest in alterations that increase the probability of tumorigenesis prompted the examination of genes whose expression was increased by the virus in the non-transformed cells and whose level remained high in the tumor. This strategy led to the identification of a novel HCV target gene: GOLT1B, which encodes a protein involved in ER-Golgi trafficking. We further show that GOLT1B expression is induced during the unfolded protein response, that its presence is essential for efficient viral replication, and that its expression is correlated with poor outcome in HCC.
Genome-Wide Identification of Stress-Associated Proteins (SAPs) Encoding A20/AN1 Zinc Finger in Almond (Prunus dulcis) and Their Differential Expression during Fruit Development
Authors: Fatima Sidra , Zafar Zeeshan , Gul Alvina , Bhatti Muhammad Faraz
Published: January 2022

Stress-associated proteins (SAPs) are zinc finger proteins involved in the regulation of various stresses in a variety of plant species. A total of nine PdSAP genes were identified in Prunus dulcis. Phylogenetic and synteny analyses were performed to analyze the homology and evolutionary relationship of PdSAP genes. The functions of PdSAP genes were assessed by further analyses, including cis-regulatory elements, gene duplication, gene ontology, gene structure, subcellular localization, and motif pattern. This study found that PdSAP genes were unevenly distributed on chromosomes 2, 3, 6, and 7. Phylogenetic analysis of PdSAP genes with Arabidopsis thaliana and Oryza sativa suggested that six subgroups have a similar pattern of AN1 and A20 domains in each subgroup. PdSAP genes lacked duplicated blocks. The majority of PdSAP genes were localized in the nucleus region. Three hormonal and five stress cis-regulatory elements were found in the upstream promoter region of the PdSAP gene family. RNA-seq analysis revealed differential gene expression of PdSAP genes at days 12, 17, 22, 27, 32, and 37 of fruitlet development after flowering. This study identifies the SAP genes in P. dulcis and also provides insights into the expression of PdSAP genes in abnormal fruitlets with diapause atrophic growth at various developmental stages.
Kié a kockázatmentes hozam? : Arbitrázslehetőség a magyar diákhitelrendszerben
Authors: Tóth Fanni
Published: January 2022

A felsőfokú végzettséggel rendelkezőket kisebb mértékben érinti a szegénység. A végzettség megszerzése tehát létfontosságú lehet a szegénységből való kitöréshez. Magyarországon a felsőoktatás államilag finanszírozott, ingyenes elérése teljesítménytől függ. Mivel a leghátrányosabb helyzetű jelentkezők gyengébben teljesítenek, sokkal alacsonyabb eséllyel nyerhetnek felvételt valamely felsőoktatási intézmény képzésére. Az egyenlő esélyek javítása érdekében a hallgatók rendelkezésére áll egy jól megtervezett diákhitelrendszer hazánkban. A tanulmány bemutatja, hogy a felsőoktatási finanszírozási politika pillanatnyilag tovább növeli a szakadékot a szegények és tehetősebbek között. A Diákhitel 1 felvételével és annak Magyar Állampapír Plusz (MÁP Plusz) értékpapírba történő befektetésével arbitrázshozamot érhetnek el azok a hallgatók, akiknek nincs szükségük a tandíjuk és a megélhetésük hitelből történő finanszírozására. A magyar rendszer tehát ahelyett, hogy támogatná az alacsony jövedelmi hátterű diákok felzárkózási folyamatát, további támogatást nyújt a jobb körülményekkel rendelkező hallgatók számára. A nemzetközi diákhitelrendszerek példájára érdemes lenne univerzális helyett célzott megközelítést alkalmazni például kamattámogatás formájában, vagy célszerű lenne jövedelmi helyzethez kötni a hiteligénylést.
Mapas conceptuales como herramienta de aprendizaje en estudiantes de Educación Superior
Authors: Valero Ancco Vidnay Noel , Calderon Quino Katty Maribel , Morales Chipana Elias , Cornejo Valdivia Gabriela
Published: January 2022

La investigación tuvo como objetivo determinar la eficacia de los mapas conceptuales como herramienta de aprendizaje en estudiantes del Instituto Superior  Tecnológico  Público  de   Manú. La metodología corresponde al enfoque cuantitativo, con un diseño pre experimental de un solo grupo  con  pre  y  pos  prueba. La muestra estuvo conformada por 30 estudiantes seleccionados bajo un criterio no probabilístico. Las técnicas de investigación corresponden al examen con el instrumento prueba de entrada y salida y la técnica de análisis de contenido con el instrumento rúbrica. Los resultados afirman la existencia de una diferencia entre el promedio que obtuvieron los estudiantes en la prueba de entrada en relación a la prueba de salida que se aplicó después del experimento, por lo tanto, se concluye que los mapas conceptuales son eficaces como herramienta de aprendizaje del módulo de cultura artística en estudiantes del Instituto Superior Tecnológico Público de Manú.
Comprensión estructural de textos escritos en estudiantes de nivel secundaria de Lima Metropolitana
Authors: Paucca Gonzales Nelson , Cobos Ruiz Cesar , Romaní Allende Freddy Gamaniel , Rafayle Cuadra Rusbel Jhon , Paucca Gonzales Hilarion
Published: January 2022

Los problemas de comprensión de textos escritos en los estudiantes de los niveles de Educación Básica Regular en Perú, muestran cierto grado de deficiencia, por lo que la investigación tuvo como objetivo central, comparar la comprensión estructural de textos escritos en estudiantes de un colegio público  y  parroquial.   Metodológicamente la investigación corresponde al método estadístico de enfoque cuantitativo, tipo básico–no experimental y de diseño causal comparativo.   La   información   se   obtuvo a través de la técnica de la encuesta y el instrumento denominado tipo de  prueba. Esta última se aplicó a 130 estudiantes del grupo muestral. Finalmente, para el contraste de hipótesis se utilizó la prueba de Wilcoxon, la cual permitió concluir que no existen diferencias significativas estadísticas en la comprensión de  textos  escritos.  Además, de las dimensiones de microestructura, macroestructura y superestructura en estudiantes de quinto grado de nivel secundaria de la ciudad de Lima – Perú.
Satisfacción laboral y cultura organizacional en docentes universitarios en una Facultad de Ciencias de la Salud
Authors: Díaz Tinoco Angélica , Valderrama Rios Olga Giovanna , Merino Lozano Alicia Lourdes , Nuñez Zarazú Llerme , Cuba Sancho Juana Matilde
Published: January 2022

Identificar la relación de la cultura organizacional en la satisfacción laboral de los  docentes  de  una  universidad  de la costa peruana. Investigación descriptiva, correlacional y transversal. La muestra fue de 48 docentes, obtenidos mediante muestreo aleatorio simple.  Los  instrumentos  utilizados  fueron dos; la escala de satisfacción laboral SL- SPC y otro para cultura organizacional, ambos en escala de Likert. Para los análisis estadísticos se usó la correlación de Spearman. El 66.7% presentó una cultura  organizacional  neutra,  el  20.8% fuerte y el 12.5% débil. El 79.2% indicaron tener una satisfacción laboral media, 14.6% alta y solo el 6.3% baja. La cultura organizacional se relacionó con la satisfacción laboral de los docentes (r=0,375, p= 0,009).
Akuntansi DETERMINASI SISTEM PENGENDALIAN MUTU DAN SIKAP PROFESIONALISME AUDITOR TERHADAP KUALITAS AUDIT
Authors: Astuti Wati Aris , Nur Islamiati Suci Agustin
Published: January 2022

Terdapat fenomena yang terjadi di Kantor Akuntan Kota Bandung dimana kualitas audit yang dihasilkan bermasalah dalam pelaksanaan tugasnya mengenai penerapan sistem pengendalian mutu dan sikap profesionalisme auditor sehingga terjadi penundaan izin untuk auditor. Tujuan 

penelitian ini adalah untuk mengetahui, menganalisis, dan memahami bukti determinasi sistem pengendalian mutu dan sikap profesionalisme auditor terhadap kualitas audit pada Kantor Akuntan Publik di Kota Bandung.

Metode yang digunakan dalam penelitian ini adalah metode kuantitatif dengan pendekatan analisis deskriptif dan analisis verifikatif, sampel yang digunakan adalah auditor senior, supervisor dan partner dari 19 Kantor Akuntan Publik di Kota Bandung yang terdaftar di Otoritas Jasa Keuangan sebanyak 47 responden dan alat analisis yang digunakan adalah Uji Validitas, Uji Reliabilitas, Uji Normalitas, Uji Multikolinieritas, Uji Heteroskedastisitas, Regresi Linear Berganda, Koefisien Determinasi, Koefisien korelasi, dan Uji t.

Hasil dari penelitian ini menunjukkan bahwa Sistem Pengendalian Mutu, Sikap Profesionalisme Auditor dan Kualitas Audit memiliki kriteria cukup baik.
THE IMPACT OF DIVIDEND POLICY AND CAPITAL STRUCTURE ON FIRM VALUE IN AGRICULTURAL SECTOR
Authors: Luckyardi Senny , Agustini Kamelia , Nugraha Nugraha , Sari Maya
Published: January 2022

This study aims to determine the effect of Dividend Policy and Capital Structure on Agricultural Sector’s Company Value. The research method used in this study is verification method with quantitative approach. The case study was conducted on agricultural sector companies listed on the Indonesia Stock Exchange in 2015-2019. The sample used is Price Book Value (PBV) and Debt to Equity Ratio (DER) in 14 agricultural sector companies obtained from Financial Statements published on the Indonesia Stock Exchange website: www.idx.co.id for the period 2015-2019. The results showed that the variables of Dividend Policy and Capital Structure had a negative and not significant effect on company value.
Upbringing of Talents: Youth Aspect
Authors: Odegov Yu. G. , Kulapov M. N. , Karasev P. A. , Tikhonov A. R.
Published: January 2022

In the last decade of the XXth century, Russian employers began to experience difficulties with the selection of qualified personnel. The current situation was due to a structural imbalance between the supply and demand of labor and a general decline in the level of skilled personnel employed in industry. Over the years of reforms associated with the transition to market relations, the Russian industry has lost a significant number of production personnel, including people with the highest qualifications. The acute shortage, and sometimes the staff shortage, which many enterprises of the country are experiencing today are mainly of a structural nature, since the country uses technologies of different technological modes, and resource constraints on economic development from the supply of labor and its quality generations are poorly counted. According to various estimates, from 40 to 60 % of graduates of educational institutions do not work in their specialty and do not stay in the first place of work for a long period. Most leave after six months or a year. But the economy is changing rapidly. It is becoming innovative, high-tech and digital. The noted processes lead to the growth of the importance of the human factor and increase the requirements for people who enter the economy and must move it forward. For this, among other conditions, it is necessary to advance training of young personnel in the framework of newly emerging professions and even to «run ahead» somewhat in this matter. Since one of the main problems of Russian professional education today is the quality of training of specialists and qualified personnel, mastering a set of skills, characteristic of newly emerging professions and industries. The main trends against which the formation of today’s 6–14-year-old generation will take place are the subject of this article. The fourth industrial revolution is closely related to the latest technological advances – digitalization, robotization, the creation of artificial intelligence, etc., which in the short term will lead to the following: - about half of all existing professions will die out in the next decade; a huge mass of people will be without work, as the world will enter an era of high technological unemployment; the rate of technological change will be so high that workers physically do not keep up with retraining for new specialties, continuously replenishing the army of the unemployed. As a result of these transformations, not only the level, but also the structure of labor demand is changing – some professions become obsolete, others are replenished. J. Schumpeter said that the process of industrial mutation continuously reconstructs the economic structure from the inside, destroying the old and creating a new one.
Modelagem computacional de cargas não-lineares residenciais via interface gráfica ATPDraw/ Computational modeling of residential nonlinear loads via ATPDraw graphical interface
Authors: Neto Luiz Emanoel Mendes , Fernandes Júlia Oliveira , Araújo João Vitor Gomes , Breda Jáder Fernando Dias
Published: January 2022

Quando um sistema apresenta uma onda senoidal com corrente e tensão em estado de equilíbrio, e a sua frequência e amplitude são constantes, dizemos que isso é representação de uma boa qualidade de energia elétrica. De acordo com o desenvolvimento tecnológico e social, e a crescente demanda de produtos eletroeletrônicos, quando estes são conectados à rede, eles são responsáveis por causar interferências em todo o sistema devido às suas características não lineares. Este trabalho tem como intuito caracterizar os harmônicos decorrentes do uso de tais aparelhos eletroeletrônicos, pelos consumidores residenciais, tal caracterização é dada pelas simulações computacionais realizadas utilizando o ATPDraw. A partir da escolha de quatro cenários essenciais, baseados em horários de maior fluxo, as simulações individuais de cada aparelho foram feitas, constituindo um conjunto de cargas. E diante disso, foi possível avaliar o seu impacto em forma senoidal de corrente e tensão, e ao volume de harmônicos produzidos, quando não há conexão com a rede da concessionária de energia, e logo após, as simulações foram realizadas com conexão com a rede a fim de mensurar o impacto harmônico causado pelas cargas não lineares provenientes do uso de aparelhos eletroeletrônicos em uma residência específica. Os resultados obtidos mostram que, individualmente, uma residência é capaz de gerar um considerável conteúdo harmônico, e que, a mesma única residência não é capaz de causar um impacto significativo quando conectada à concessionária de energia elétrica.
Determinação de propriedades mecânicas de tração de compósitos híbridos reforçados utilizando fibras de bambu tratadas em solução NaOH e lama vermelha
Authors: Santos Alessandro José Gomes dos , Farias Dorivane Cohen , Silva Nayla Gonçalves da , Costa Deibson Silva da
Published: January 2022

Buscando sugerir novas rotas para resíduos industriais oriundos da indústria mineradora, e, também, contribuir com a pesquisa e desenvolvimento de novos materiais, de fontes renováveis e sustentáveis, desenvolveu-se neste trabalho um material compósito híbrido composto de matriz polimérica, fibras de bambu tratada quimicamente e resíduo industrial (lama vermelha). Os compósitos produzidos foram analisados quanto sua resistência à tração de acordo com a norma ASTM D3039. As análises fractográficas foram realizadas por Microscopia Eletrônica de Varredura (MEV). O compósitos que apresentou melhor desempenho mecânico foi para proporção 3 %/10 % (fibra/resíduo) com um limite de 35,30 MPa. A fractografia realizada nas morfologias das fraturas dos compósitos demonstraram mecanismos como: trincas na matriz, descolamento e desfibrilamento de fibras, fibras rompidas e fibras arrancadas (pull-out).
A relevância da atenção farmacêutica no manejo de reações adversas no tratamento oncológico: uma revisão sistemática / The relevance of pharmaceutical care in the management of adverse reactions in oncologic treatment: a systematic review
Authors: Soares Laiara Da Cruz , Sena Marlon Macedo , Peres Sandra Da Costa , Pinheiro Shayna Vilaça
Published: January 2022

Introdução: a atenção farmacêutica visa a melhoria da qualidade de vida do paciente, através de um modelo de prática profissional voltada à farmacoterapia inclusive em tratamentos oncológicos, dos quais muitas vezes são desconfortáveis para o paciente devido aos seus efeitos adversos. O profissional farmacêutico, dessa forma, tem o papel de tornar o tratamento menos oneroso para os pacientes.Objetivo: este trabalho tem como objetivo descrever a importância da atenção farmacêutica no tratamento oncológico, relatando a importância do acompanhamento do profissional farmacêutico para adesão do tratamento e efeitos colaterais mais comuns relatados pelos pacientes. Metodologia: para alcançar os dados esperados será utilizado um estudo de revisão bibliográfica, através do método prisma, com artigos dos anos de 2015 a 2020. A atenção farmacêutica em usuários de tratamento oncológico, também proporciona orientações sobre as prescrições e esclarece as queixas e dúvidas técnicas referentes ao uso dos antineoplásicos. Desta forma, tem-se o intuito de demostrar que a presença do profissional farmacêutico na atenção ao paciente em tratamento oncológico visa essencialmente promover condutas de prevenção, promoção, reabilitação, recuperação, de forma segura e eficaz.Resultados: foram identificados ao todo identificados 233 trabalhos, sendo selecionados 22 trabalhos que correspondiam aos critérios de elegibilidade escolhidos. Os artigos foram divididos em relação à temática abordada respondendo os objetivos dispostos nessa pesquisa. Quanto as reações adversas reportadas por farmacêuticos, é observável a importância deste profissional devido seu conhecimento clínico em reconhecê-las e classificá-las em relação ao seu risco. O farmacêutico em maioria das intervenções aplicadas, obteve um grande sucesso em relação a melhora do tratamento do paciente e consequentemente qualidade de vida deste. A interação entre o farmacêutico e a equipe multiprofissional demonstrou-se ser de grande importância devido a facilidade de criar propostas de intervenção para os problemas relacionados a medicamentos identificados. Conclusão: o farmacêutico é um elemento crucial em oncologia quando se trata de identificar e reportar reações adversas de forma a otimizar tratamentos, diminuir desconforto e melhorar da qualidade de vida do paciente quando se há a comunicação ideal entre os profissionais da equipe oncológica.
Parâmetros antropométricos, bioquímicos como indicadores de riscos cardiovasculares em usuários de antipsicóticos / Anthropometric, biochemical parameters as indicators of cardiovascular risks in antipsychotic users
Authors: De Ataíde Bruno Rafael Batista , Pereira Glendson de Sousa , Rocha Naiara Carvalho , Guterres Aldair da Silva , Torres Rosileide de Souza
Published: January 2022

Atualmente o tratamento mais eficaz para pacientes com transtornos mentais veem sendo os antipsicóticos, entretanto, o uso dessas drogas, tanto as de primeira geração quanto às de segunda geração, ocasionam importantes efeitos adversos.  O presente trabalho tem como objetivo, avaliar os parâmetros antropométricos, bioquímicos e suas correlações como preditores de risco cardiovascular em usuários de antipsicóticos internados em um serviço de internação breve. Foram avaliados 113 pacientes, portadores de esquizofrenia internados em um hospital de referência em psiquiatria. Avaliou-se os parâmetros antropométricos, bioquímicos e suas correlações, com significância estatística de p < 0,05. Os resultados apresentaram que 50,4% dos avaliados apresentavam sobrepeso, dentre os lipídeos, os triglicerídeos com 153.8±24.1 mg/dL e o LDL-c 114.5±26.8 mg/dL estavam com as médias acima dos valores recomendados, ao correlacionar os parâmetros antropométricos e bioquímicos, demonstrou-se valores positivos, exceto para a correlação triglicerídeos e HDL-c, desmontando indicativos de risco para doenças cardiovasculares no público estudado.  Concluímos que apesar dos efeitos positivos no controle das psicoses e auxilio na melhora dos transtornos mentais, os antipsicóticos geram alguns danos a níveis metabólicos nos seus usuários, propiciando o risco de complicações cardiovasculares e a presença de diabetes tipo 2, diminuindo assim a expectativa de vida desses pacientes.
Biográfica: Viagem narrativa mediada por artefato de formação na relação entre professor e estudante / Biographical: Narrative journey mediated by artifact of formation in the relationship between teacher and student
Authors: Da Costa Tabata Afonso , Barreiro Cristhianny Bento , Weymar Lúcia Bergamaschi Costa
Published: January 2022

O presente artigo apresenta uma síntese da pesquisa desenvolvida no âmbito da sala de aula com o livro de artista intitulado “Biográfica”. O livro abarca fragmentos de vida, lembranças, objetos e músicas que deflagram diversas inquietações e originam a questão que orienta a pesquisa: "o que produz nos estudantes ter acesso/conhecer as narrativas de vida do professor?”. Considerando essa questão, o objetivo principal do estudo foi compreender os efeitos que as narrativas de vida docente podem produzir nos estudantes, tendo o livro de artista sido ajustado para ser utilizado na pesquisa, passando a ser denominado artefato de formação. A partir da metodologia qualitativa e baseada no método de investigação narrativa, foram definidos dois momentos para produção de dados: primeiramente a aplicação do artefato de maneira individual com cada uma das quatro estudantes que participaram da investigação; seguida de uma entrevista conversa realizada de modo online devido à pandemia da Covid-19. Foram utilizados conceitos ligados à construção do sujeito, sua identidade e suas ancoragens coletivas, relação entre professor e estudante, espaços de intersubjetividade e aproximações com a investigação narrativa, a partir de autores como Hall (1999), Josso (2004, 2007, 2010, 2014), Clandinin e Connelly (2011), Maturana (1995, 1997, 2002), dentre outros. Os dados produzidos foram analisados e trazidos à pesquisa de maneira narrativa, inserindo as inquietações, aprendizados e novos questionamentos. Como resultados, aponta-se a relevância para todos os envolvidos na percepção do livro Biográfica como artefato de formação, indicando que a experiência foi produtora de espaços de intersubjetividade e apontada como um “aproximador” ao atuar na relação professor-estudante no âmbito da educação.
Manifestações patológicas: Fissuras em estrutura de concreto armado e alvenaria estrutural, estudo de caso em duas obras unifamiliares / Pathological manifestations: Cracks in reinforced concrete structure and structural masonry, case study in two single-family works
Authors: De Moura Felipe Lins , Miranda Walzenira Parente , Pinheiro Érika Cristina Nogueira Marques
Published: January 2022

O respectivo artigo tem por fim indicar, de acordo com as normas vigentes e análise diagnóstica em obra, as manifestações patológicas, mais especificamente as principais causas de fissurações em edificações que ocorrem em estrutura de concreto armado e alvenaria estrutural. Para assim, examinar o surgimento de fissuras em duas obras unifamiliares, quais são os tipos de fissuras e classificá-las de acordo com suas características. Para então, determinar as possíveis causas de seu desenvolvimento e propor soluções nas patologias encontradas nas obras em um estudo de caso.