bluuebunny/crossref_metadata_2025 huggingface dataset:
Closed loop control of lactate concentration in mammalian cell culture by Raman spectroscopy leads to improved cell density, viability, and biopharmaceutical protein production
Authors: Matthews Thomas E. , Berry Brandon N. , Smelko John , Moretto Justin , Moore Brandon , Wiltberger Kelly
Published: May 2016

Accumulation of lactate in mammalian cell culture often negatively impacts culture performance, impeding production of therapeutic proteins. Many efforts have been made to limit the accumulation of lactate in cell culture. Here, we describe a closed loop control scheme based on online spectroscopic measurements of glucose and lactate concentrations. A Raman spectroscopy probe was used to monitor a fed‐batch mammalian cell culture and predict glucose and lactate concentrations via multivariate calibration using partial least squares regression (PLS). The PLS models had a root mean squared error of prediction (RMSEP) of 0.27 g/L for glucose and 0.20 g/L for lactate. All glucose feeding was controlled by the Raman PLS model predictions. Glucose was automatically fed when lactate levels were beneath a setpoint (either 4.0 or 2.5 g/L) and glucose was below its own setpoint (0.5 g/L). This control scheme was successful in maintaining lactate levels at an arbitrary setpoint throughout the culture, as compared to the eventual accumulate of lactate to 8.0 g/L in the historical process. Automated control of lactate by restricted glucose feeding led to improvements in culture duration, viability, productivity, and robustness. Culture duration was extended from 11 to 13 days, and harvest titer increased 85% over the historical process. Biotechnol. Bioeng. 2016;113: 2416–2424. © 2016 Wiley Periodicals, Inc.
A Solvent‐dependent Fluorogenic Probe Containing Julolidine for Cr(III) and Cu(II)
Authors: Anjong Tikum Florence , Park Yu Mi , Jang Ha Yoon , Kim Jinheung
Published: May 2016

A julolidine‐containing naphthylamine probe (EW1) was prepared for sensing specific metal ions. Probe EW1 afforded a broad low fluorescence at 500–600 nm in acetonitrile, but gave a relatively stronger fluorescence at 540 nm in methanol. EW1 showed a selective turn‐on emission for Cr3+ in CH3CN. Upon treatment with Cr3+, a strong emission was observed at 515 nm, but other metal ions, such as K+, Ag+, Ca2+, Zn2+, Co2+, Ni2+, Cu2+, Cd2+, Hg2+, Fe2+, and Fe3+, failed to induce such an emission band. A clean isosbestic point appeared at 405 nm in the UV–vis titration with Cr3+. The emission intensity of EW1 was enhanced with incremental addition of Cr3+, indicating the formation of a 1:1 complex of the probe EW1 and chromium ion. However, EW1 showed a selective turn‐off response with Cu2+ in CH3OH. The emission band of EW1 at 540 nm was quenched only with Cu2+ and not with other control metal ions. The absorption band of EW1 at 410 nm progressively decreased, and a new absorption at 390 nm appeared upon progressive addition of Cu2+. All spectroscopic titration experiments and ESI mass data provided evidence for the formation of a 1:1 complex between EW1 and Cu2+.
Reverse‐phase high‐performance liquid chromatography for the simultaneous determination of sildenafil and N‐desmethyl sildenafil in plasma of children
Authors: Goffredo Bianca Maria , Cairoli Sara , Vitale Alessia , Corsetti Tiziana , Pastore Anna
Published: May 2016

Sildenafil is a selective inhibitor of cGMP‐specific type 5 phosphodiesterase used for the treatment of pulmonary arterial hypertension (PAH) in the adults. In pediatrics, PAH treatment options include the off‐label use of sildenafil. Sildenafil is metabolized in the liver by cytocrome P450 into its active metabolite, N‐desmethyl sildenafil. The determination of plasma levels of sildenafil and N‐desmethyl sildenafil could be useful for therapy optimization and pharmacokinetic studies. We have developed and validated a method for the quantification of sildenafil and its metabolite in plasma of children by rapid extraction, using high‐performance liquid chromatography with ultraviolet detection. The calibration range was fitted at least square model (r2 ≥ 0.999), with an accuracy and an intra‐ and inter‐day relative standard deviation <15% for both analytes. The mean recovery was 102.5% for sildenafil and 101.8% for N‐desmethyl sildenafil. This simple method could be successfully used in children with PAH under treatment with sildenafil.
Improvement of the reflective learning in engineering education using MATLAB for problems solving
Authors: Vicéns José L. , Zamora Blas , Ojados Dolores
Published: May 2016

This paper presents a procedure for the improvement of the reflective learning in Engineering, including the use of MATLAB for problems solving. Three effects are produced in students. The first, the searching of the solution of a particular case is substituted by the modeling of the general problem. The second, a reflection on their theoretical knowledge is encouraged. The third, the motivation for an autonomous learning of MATLAB is increased, taking into account the clear interest of this tool in the teaching–learning in Engineering. Lastly, several benchmark problems are presented and discussed. © 2016 Wiley Periodicals, Inc. Comput Appl Eng Educ 24:755–764, 2016; View this article online at wileyonlinelibrary.com/journal/cae; DOI 10.1002/cae.21748
Preprocedural fractional flow reserve and microvascular resistance predict increased hyperaemic coronary flow after elective percutaneous coronary intervention
Authors: Murai Tadashi , Kanaji Yoshihisa , Yonetsu Taishi , Lee Tetsumin , Matsuda Junji , Usui Eisuke , Araki Makoto , Niida Takayuki , Isobe Mitsuaki , Kakuta Tsunekazu
Published: May 2016

Background

Epicardial focal coronary artery stenosis, diffuse coronary disease, and microvascular resistance (MR) may limit coronary flow. The purpose of percutaneous coronary intervention (PCI) is to increase coronary flow by targeting epicardial lesions. After PCI, MR might change and affect coronary flow. We investigated whether PCI influences MR using the index of microcirculatory resistance (IMR) and if pre‐PCI fractional flow reserve (FFR) or MR predicts the post‐PCI change in hyperaemic coronary flow.

Methods and Results

This prospective study included 245 vessels from 229 patients with stable angina pectoris undergoing elective PCI. FFR and IMR were measured before and after PCI. Post‐PCI increase in hyperaemic coronary flow was assessed using the change in thermodilution‐derived transit time (pre‐PCI Tmn – post‐PCI Tmn). IMR significantly decreased after PCI (median 1.9; interquartile range, −4.9 to 10.1) and was significantly associated with pre‐PCI IMR (r = 0.70, P < 0.001). Increased coronary flow was significantly correlated with pre‐PCI IMR (r = 0.62, P < 0.001) and pre‐PCI FFR (r = 0.51, P < 0.001). In multivariate analysis, factors significantly associated with decreased post‐PCI IMR were pre‐PCI IMR (odds ratio [OR], 1.13; 95% confidence interval [CI], 1.08–1.19; P < 0.001) and angiographic reference diameter (OR, 2.44; 95% CI; 1.09–5.48; P = 0.03). Factors significantly associated with increased coronary flow post‐PCI were pre‐PCI IMR (OR, 1.15; 95% CI, 1.08–1.23; P < 0.001) and pre‐PCI FFR (OR, <0.001; 95% CI, 0.000–0.003; P < 0.001).

Conclusion

PCI affected MR. Pre‐PCI FFR and MR were independent predictors of post‐PCI changes in hyperaemic coronary flow. © 2016 Wiley Periodicals, Inc.
Invasive angiography and revascularization in patients with stable angina following prior coronary artery bypass grafting: Results from the East Denmark heart registry
Authors: Joshi Francis R. , Biasco Luigi , Pedersen Frants , Holmvang Lene , Helqvist Steffen , Tilsted Hans‐Henrik , Abildgaard Ulrik , Kelbaek Henning , Lassen Jens F. , Jørgensen Erik , De Backer Ole , Engstrøm Thomas
Published: May 2016

Background

There are limited data to guide the optimum approach to patients presenting with angina after coronary artery bypass grafting (CABG). Although often referred for invasive angiography, the effectiveness of this is unknown; angina may also result from diffuse distal or micro‐vascular coronary disease and it is not known how often targets for intervention are identified.

Methods

Retrospective review of 50,460 patients undergoing angiography in East Denmark between January 2010 and December 2014. Clinical and procedural data were prospectively stored in a regional electronic database. Follow‐up data were available for all patients, by means of records linked to each Danish social security number.

Results

In patients with prior CABG and stable angina (n = 2,309), diagnostic angiography led to revascularization in 574 (24.9%) cases. Chronic kidney disease (HR 1.93 [1.08–3.44], P = 0.027), significant angina (HR 1.49 [1.18–1.88], P = 0.006 for angina class ≥ II, and HR 2.04 [1.61–2.58], P < 0.001 for angina class ≥ III) and a positive pre‐procedural stress test (HR 2.56 [1.42–4.60], P < 0.001) were independent predictors of revascularization. Stress testing was, however, used less frequently than in patients without prior CABG (17.2% vs. 24.2%, P < 0.001). The positive predictive values for subsequent revascularization were 47.8%, 51.4%, and 66.9% for exercise ECG, stress echocardiography, and myocardial perfusion scintigraphy (MPS), respectively.

Conclusions

Invasive angiography leads to revascularization in a quarter of patients with angina and prior CABG; the threshold for referral may be too low. Non‐invasive stress testing predicts the need for revascularization but appears underused and MPS, in particular, may better identify patients likely to require revascularization. © 2016 Wiley Periodicals, Inc.
Hyperpolarization of Nitrogen‐15 Schiff Bases by Reversible Exchange Catalysis with para‐Hydrogen
Authors: Logan Angus W. J. , Theis Thomas , Colell Johannes F. P. , Warren Warren S. , Malcolmson Steven J.
Published: May 2016

NMR with thermal polarization requires relatively concentrated samples, particularly for nuclei with low abundance and low gyromagnetic ratios, such as 15N. We expand the substrate scope of SABRE, a recently introduced hyperpolarization method, to allow access to 15N‐enriched Schiff bases. These substrates show fractional 15N polarization levels of up to 2 % while having only minimal 1H enhancements.
ChemInform Abstract: Semiconductor‐Metal Transition in Bismuth Pyrochlores of the Bi2Pt2‐yIryO7 System.
Authors: BECK E. , KEMMLER‐SACK S.
Published: May 2016

Bi2Pt2O7, prepared for the first time under normal pressure, is a semiconductor and forms a continuous series of solid solutions with the metallic conductor Bi2Ir2O7.
ChemInform Abstract: Metal Carbonate Equilibria. Part 16. Beryllium(II)‐Water‐Carbon Dioxide(g) System in Neutral‐to‐Alkaline 3.0 mol dm‐3 Perchlorate Media at 25 °C.
Authors: BRUNO J. , GRENTHE I. , MUNOZ M.
Published: May 2016

Solubility and e.m.f. data are explained by assuming that (I) is the predominant species responsible for the solubility of β‐Be(OH)2 in bicarbonate solutions.
ChemInform Abstract: In situ Surface Extended X‐Ray Absorption Fine Structure Spectroscopy of a Lead Monolayer at a Silver(111) Electrode/Electrolyte Interface.
Authors: SAMANT M. G. , BORGES G. L. , GORDON J. G. II , MELROY O. R. , BLUM L.
Published: May 2016

A Pb adlayer on a Ag(111) electrode has been generated by underpotential deposition (UPD) from aqueous acetate solution, and its X‐ray absorption spectrum is obtained, at the PbLIII edge, with the use of fluorescence detection and grazing incidence excitation.
ChemInform Abstract: Ultrahigh Resolution in Proton NMR Spectra at 500 MHz: Two‐Bond Intrinsic Chlorine and Silicon Isotope Effects.
Authors: ANET F. A. L. , KOPELEVICH M.
Published: May 2016

It is shown that 37Cl/35Cl isotope effects on the 1H chemical shifts in chlorinated methanes CH3Cl, CHDCl2, and CHCl3 are about + 0.2 ppb (ca.
ChemInform Abstract: Template‐Controlled Oligomerization of Methyl Methacrylate
Authors: FELDMAN K. S. , LEE Y. B.
Published: May 2016

(VI).
ChemInform Abstract: Dynamics of the Wolff Rearrangement: Spectroscopic Evidence of Oxirene Intermediate.
Authors: TANIGAKI K. , EBBESEN T. W.
Published: May 2016

Spectroscopic and trapping experiments point to the fact that the first intermediate detected in the photolysis of the diazoketone (I) is the oxirene (III) and that the ketone (IV) is formed from it giving the final product, the acid (V), by reaction with water.
ChemInform Abstract: Do the Organocopper Conjugate Additions to α,β‐Unsaturated Esters Proceed in a 1,4‐ or 1,2‐Fashion?.
Authors: YAMAMOTO Y. , YAMADA J. , UYEHARA T.
Published: May 2016

The organocopper conjugate addition to methyl tiglate (I) or angelate (IV) followed by protonolysis gives the syn (II) and anti (III) adducts in the same isomer ratio.
ChemInform Abstract: Simple Syntheses of 2‐Hydroxymethyl‐1,3‐propanediol and Related Compounds.
Authors: LATOUR S. , WUEST J. D.
Published: May 2016

2‐Hydroxymethyl‐2‐nitro‐1,3‐propanediol (Ia) is converted to the title compound (Va) by consecutive acylation, replacement of the nitro group by hydrogen, and methanolysis.
ChemInform Abstract: Dihydropentalenes.
Authors: MEIER H. , PAULI A. , KOLSHORN H. , KOCHHAN P.
Published: May 2016

Applying the MNDO method the enthalpies of formation and the frontier orbitals of the six isomeric dihydropentalenes are calculated (ΔHf = 50.7, 50.8, 54.9, 55.4 kcal/mol for (II)‐(V) in the order given and 59.0 and 60.0 kcal/mol for the 1,6a‐ and 1,3a‐dihydroisomer, respectively).
ChemInform Abstract: Synthesis and Solvolysis of Cyclic Dienynyl Triflates.
Authors: HANACK M. , RIETH R.
Published: May 2016

The cyclic enyne ketones (II) are prepared from the dienes (I) by a known procedure and converted to the title compounds (IV) and (VI).
ChemInform Abstract: Phenylsulfonyl‐Substituted Octabisvalenes. Syntheses and Reactions.
Authors: RUECKER C. +
Published: May 2016

The bis(phenylsulfonyl) derivative (X), the first derivative of octabisvalene, is synthesized in preparatively useful quantities in an eight‐step sequence starting from cis‐benzene trioxide (I) via the intermediates shown in the scheme.
ChemInform Abstract: Preparation of Anilinomethylenepropanedioic Acid Alkyl Esters by Direct Condensation.
Authors: MUNOZ H. , TAMARIZ J. , ZAMORA H. S. , LAZARO M. , LABARRIOS F.
Published: May 2016

The anilines (I) are coupled with triethyl orthoformate (II) and diethyl malonate (III) in the presence of acetic anhydride and zinc chloride to produce the anilinomethylenemalonates (IV).
ChemInform Abstract: Organosulfur Compounds. Part 42. N‐Bromosuccinimide‐Catalyzed Transesterification and Racemization of Sulfinates.
Authors: DRABOWICZ J.
Published: May 2016

Transesterification of the sulfinates (III), prepared from the sulfinyl chlorides (I) and the alcohols (II), with an excess of the alcohols (IV) is catalyzed by N‐bromosuccinimide.
ChemInform Abstract: Synthesis, Conformation, and Structure of 8,11‐Bis(methoxycarbonyl)‐(6)paracyclophane.
Authors: TOBE Y. , NAKAYAMA A. , KAKIUCHI K. , ODAIRA Y. , KAI Y. , KASAI N.
Published: May 2016

Photocycloaddition of the enone (I) with methyl acrylate (II) gives the isomeric adducts (III) and (IV).
ChemInform Abstract: The Gas‐Phase Photolysis of Perfluoro α‐Diazo Ketones: Furan Formation and the Involvement of Transient Oxirenes.
Authors: MAHAFFY P. G. , VISSER D. , TORRES M. , BOURDELANDE J. L. , STRAUSZ O. P.
Published: May 2016

Gas‐phase photolysis of the diazo ketone (I) in the presence of hexafluoro‐2‐butyne (II) as the trapping agent yields the furan (III) as the main product.
ChemInform Abstract: Azadiene Chemistry. Part 8. Polycyclic Amines via Novel (2 + 2) Cycloaddition of Imine.
Authors: RAMMASH B. KH. , ATWOOD J. L. , WEEKS J. A. , WONG J. L.
Published: May 2016

Perchloroazacyclopentadiene (I) reacts with norbornadiene (II) to give the azaaldrin (III) and the isoazaaldrin (IV) as reported previously, together with the urazole‐type adduct (V).
ChemInform Abstract: Synthesis of 2,6‐Diformyl‐3‐hydroxypyridine Bis(N‐methyl‐N‐(2′‐pyridyl)hydrazone): A Pentadentate N,N,N,N,N‐Ligand for the Preparation of Chelating Resins.
Authors: BALDO M. A. , CHESSA G. , MARANGONI G. , PITTERI B.
Published: May 2016

The synthesis of the title compound (VII) from 2‐bromopyridine (I) and 3‐hydroxypyridine (IV) is described.
ChemInform Abstract: A Derivative of 1,3‐Indandione from Phthalaldehyde.
Authors: DUSEMUND J. , KROEGER E. +
Published: May 2016

Treatment of phthalic aldehyde (I) with sodium methoxide gives a mixture of the compounds (II) ‐ (IV) as a result of intramolecular Cannizzaro and subsequent reactions.
ChemInform Abstract: Preparation of Substituted Tetrahydroxy‐1,4‐benzoquinones.
Authors: DALLACKER F. , BOTH‐POLLMANN E.‐M.
Published: May 2016

The tetraalkoxy‐p‐benzoquinones (II) and (VII) are prepared by treatment of the phenols (Ib), (V), or (VIII) with potassium nitrosodisulfonate or by oxidation of the corresponding hydroquinones (IIId) and (VI).
ChemInform Abstract: Transformation of Pyrrolidine Enaminothiones into 4,5‐Dihydro‐6H‐thieno(2,3‐c)azepines.
Authors: DANNHARDT G. , GROBE A. , OBERGRUSBERGER R.
Published: May 2016

The pyrrolidine enaminothiones (I) react with the bromomethyl ketones (II) to form the intermediate spiroheterocycles (III) which are rearranged with triethylamine, yielding the thienoazepins (IV).
ChemInform Abstract: Dibisyldiphosphene: New Routes and First Aspects of Its Reactivity.
Authors: RANAIVONJATOVO H. , ESCUDIE J. , COURET C. , SATGE J.
Published: May 2016

Two methods of preparing the dibisyldiphosphene (V) are investigated as shown in the reaction scheme.
ChemInform Abstract: Equilibria Studies Involving Ligand Coordination to “Open Titanocenes”: Phosphine and Pentadienyl Cone Angle Influences and the Existence of these Electron‐Deficient Molecules.
Authors: STAHL L. , ERNST R. D.
Published: May 2016

The phosphine adducts (I) are prepared in high yields by the two reactions shown in the scheme for the synthesis of (Ia).
ChemInform Abstract: Synthesis and Ring Inversion of the First Hafnocene Ditellurolene Chelate: ((η5‐C5H5)2Hf(1,2‐Te2C6H4)).
Authors: KLAPOETKE TH. + , KOEPF H. + , GOWIK P.
Published: May 2016

The title complex (Ia) is the last missing member of the widely investigated subgroup (IV) metallocene dichalcogenolene chelate complexes (I).
ChemInform Abstract: Linear N‐Acyl Imines. An Independent Class of Compounds? Part 1. N‐Acyl Aldimines
Authors: MALASSA I. , MATTHIES D.
Published: May 2016

Review: (44 refs.
ChemInform Abstract: Discharge Flow Kinetic Study of NO3 Reactions with Free Radicals: The Reaction of NO3 with Cl.
Authors: MELLOUKI A. , LE BRAS G. , POULET G.
Published: May 2016

The rate constant of the reaction shown in the scheme is directly measured using the discharge flow technique to be k1 = 2.6·10‐11 cm3 molecule‐1 s‐1at 298 K. The measurements are performed under pseudo‐first‐order conditions with NO3 in excess which is produced via the second reaction in the scheme (k2 = 2.7·10‐11 cm3 molecule‐1 s‐1.
ChemInform Abstract: Total Synthesis of Debromoaplysiatoxin and Aplysiatoxin.
Authors: PARK P. , BROKA C. A. , JOHNSON B. F. , KISHI Y.
Published: May 2016

The synthesis of debromoaplysiatoxin (IXa) starts from the reaction between the sulfone (I) and the epoxide (II) and is carried out as shown in the scheme.
ChemInform Abstract: Morphological and Thermal Investigations of the “Active” Dimer Hydroxide of Chromium(III)
Authors: SPICCIA L. , MARTY W. , GIOVANOLI R.
Published: May 2016

, (Cr2(μ‐OH)2(OH)4(OH2)4)·2 H2O (I), have been performed by means of IR spectroscopy, XRD, electron microscopy and thermal analysis (TG,DTG,DSC).
ChemInform Abstract: Organic Sulfur Compounds. Part 14. Reactions of 1,2,2,6,6‐Pentamethyl‐ 4‐oxothianium Tetrafluoroborate with Alkali Metal Halides in a Solid State.
Authors: OHASHI T. , TOKUNO K. , OTODA Y.
Published: May 2016

The oxothianium salt (I) mentioned in the title is treated with alkali halides in the solid state.
ChemInform Abstract: Synthesis and Thermal Reactions of New Cyclic Sulfur Ylides Possessing 10π Electrons, 8‐Alkyl‐1,3‐diphenyl‐2H‐dibenzo(b,f)cyclopenta(d)thiepinio‐2‐ides.
Authors: HORI M. , OKITSU M. , KATAOKA T. , SHIMIZU H.
Published: May 2016

The cyclopentadienodibenzothiepin (II), prepared by reduction of the ketone (I), is alkylated with the iodides (III) in the presence of silver chlorate to form the thiaazulenium salts (IV).
ChemInform Abstract: Enzymatic Lactonization of γ‐Hydroxy Esters in Organic Solvents. Synthesis of Optically Pure γ‐Methylbutyrolactones and γ‐Phenylbutyrolactones.
Authors: GUTMAN A. L. , ZUOBI K. , BOLTANSKY A.
Published: May 2016

The γ‐hydroxy esters (I) are cyclized with porcine pancreatic lipase to form the lactones (II).
ChemInform Abstract: Ab initio Studies of NH3···X2 Complexes.
Authors: KULKARNI G. V. , CHANDRA A. K.
Published: May 2016

Ab initio SCF MO calculations on molecular complexes of NH3 with Li2, C2, and N2 using the 4‐31G basis set show ammonia to form stable van der Waals' complexes with Li2 and C2.
ChemInform Abstract: Sintering and Mechanical Properties of Yttria‐Doped Tetragonal ZrO2 Polycrystal/Mullite Composites.
Authors: ISHITSUKA M. , SATO T. , ENDO T. , SHIMADA M.
Published: May 2016

Sintering of the title composites at 1450‐1500 °C in air causes development of rodlike mullite grains (aspect ratio > 2) at the grain boundaries.
ChemInform Abstract: Phase Equilibria in the Iron Oxide‐Cobalt Oxide‐Phosphorus Oxide System.
Authors: DE GUIRE M. R. , PRASANNA T. R. S. , KALONJI G. , O'HANDLEY R. C.
Published: May 2016

Determination of the solid‐state equilibria in the Fe2O3‐FePO4‐Co3(PO4)2‐CoO system in air at 1000 °C show the previously unknown compounds CoFe(PO4)O (I) and Co3Fe4(PO4)6 (II) to be stable.
ChemInform Abstract: Oxygen Evolution on Ru and RuO2 Electrodes Studied Using Isotope Labelling and On‐Line Mass Spectrometry.
Authors: WOHLFAHRT‐MEHRENS M. , HEITBAUM J.
Published: May 2016

The isotope labelling experiments clearly show that the oxide layer is involved in the O2 evolution process on Ru electrodes that are oxidized in H2O and on RuO2 film electrodes.
ChemInform Abstract: Variation of Catalytic Activity over PtRe/γ‐Al2O3.
Authors: AUGUSTINE S. M. , SACHTLER W. M. H.
Published: May 2016

The hydrogenolysis and the deuterium exchange of cyclopentane have been studied over a series of PtRe/γ‐Al2O3 catalysts with similar metal loading but varying Pt/Re ratios.
ChemInform Abstract: Regioselectivity of Addition of Thiols and Amines to Conjugated Allenic Ketones and Esters.
Authors: SUGITA T. , EIDA M. , ITO H. , KOMATSU N. , ABE K. , SUAMA M.
Published: May 2016

The allenyl ketones (I) are coupled with the thiols or amines (II) to give the adducts (III) and/or (IV).
ChemInform Abstract: Photoactivation of Metal Oxide Surfaces: Photocatalyzed Oxidation of Alcohols by Heteropolytungstates.
Authors: FOX M. A. , CARDONA R. , GAILLARD E.
Published: May 2016

Photoinduced oxidation of alcohols such as (I) catalyzed by several tungstates of varying structural complexity (e.g.
ChemInform Abstract: Photochemistry of Polyenes. Part 24. Regioselective Photoisomerization of Fluoro Aryl Dienes. Role of Dipolar Intermediates of Excited Dienes.
Authors: MUTHURAMU K. , LIU R. S. H.
Published: May 2016

With the exception of (Ia), all photoisomerizations are highly regioselective, favoring formation of 4‐cis isomers (IIb)‐(IId).
ChemInform Abstract: A Novel Synthesis of 1‐Naphthyl Methyl Carbamate from Ethyl Acetate.
Authors: NAYAK U. R. , DEODHAR V. B. , DALAVOY V. S.
Published: May 2016

Ethyl acetate (I) is converted to the azide (III) via the hydrazide (II).
ChemInform Abstract: The Biscycloadduct of Hexamethyl‐2,4‐cyclohexadienone and a 1,4‐Benzadiyne Equivalent.
Authors: OK D. , HART H.
Published: May 2016

The diaminobenzobistriazole (I) which is a synthetic equivalent of 1,4‐benzadiyne reacts with the hexamethylcyclohexadienone (II) in the presence of lead tetraacetate to produce the bisadduct (III).
ChemInform Abstract: Thiophene as a Structural Element of Physiologically Active Compounds. Part 16. Thienoisoxazoles by Substitution at the Oxime Nitrogen.
Authors: BINDER D. , NOE C. R. , HOLZER W. , BAUMANN K.
Published: May 2016

The hydroxythienopyranone (I) reacts with hydroxylamine to produce the thienoisoxazole (II).
ChemInform Abstract: An Entry to the Optically Pure β‐Lactam Skeleton Based on 1,3‐Dipolar Cycloaddition of Nitrones to 4,6‐Di‐O‐acetyl‐2,3‐dideoxy‐D‐threo‐hex‐2‐ enone‐1,5‐lactone.
Authors: PANFIL I. , BELZECKI C. , CHMIELEWSKI M.
Published: May 2016

Cycloaddition reaction of the nitrones (II) with the unsaturated lactone (I) yields stereoselectively the adducts (III) as the main products, together with (IV).
ChemInform Abstract: Synthesis and Antifungal Activity of New 1‐Vinylimidazoles.
Authors: OGATA M. , MATSUMOTO H. , SHIMIZU S. , KIDA S. , SHIRO M. , TAWARA K.
Published: May 2016

Reaction of the o‐hydroxyacetophenones (I) with the sulfoxides (II) gives the 1‐vinylimidazoles and ‐triazoles (III) which are alkylated to yield the derivatives (V).
ChemInform Abstract: Endoperoxides as Potential Antimalarial Agents.
Authors: KEPLER J. A. , PHILIP A. , LEE Y. W. , MUSALLAM H. A. , CARROLL F. I.
Published: May 2016

Photooxygenation of the dienes (VIII) which are obtained from the octalin derivative (I) as outlined in the reaction scheme gives the corresponding endoperoxides (IXa) ‐ (IXc).
ChemInform Abstract: Reaction of Sulfenes with Heterocyclic N,N‐Disubstituted α‐Aminomethylene Ketones. Part 8. Synthesis of 1,2‐Oxathiino(6,5‐f)quinazoline Derivatives.
Authors: MENOZZI G. , BARGAGNA A. , MOSTI L. , SCHENONE P.
Published: May 2016

The aminomethylenequinazolinones (I) react with the sulfene (II), generated in situ from methanesulfonyl chloride and triethylamine, to give the adducts (III).
ChemInform Abstract: Ethylation of Pyrazines Using Alkylmetals, such as Triethylaluminum, Diethylzinc, and Triethylborane.
Authors: OHTA A. , OHTA M. , IGARASHI Y. , SAEKI K. , YUASA K. , MORI T.
Published: May 2016

Ethylation of the chloropyrazines (I) with triethylborane (II) yields the ethyl derivatives (III), together with the dechlorinated by‐products (IV).
ChemInform Abstract: Action of Nitrogen Nucleophiles on Oxiranes of β‐Aroylacrylic Acids.
Authors: OMRAN S. A. , SALEM M. A. I. , HARB N. S. , MARZOUK M. I.
Published: May 2016

The epoxides (II) are subjected to various conversions such as basic hydrolysis or condensation with the N‐nucleophiles (V) and (VIII) or hydroxylamine hydrochloride.
ChemInform Abstract: Rearrangement of a Substituted Epoxytetrahydropyran to the Corresponding Tetrahydrofurancarbaldehyde.
Authors: SEQUIN U. , SCHNEIDER A.
Published: May 2016

Treatment of the epoxytetrahydropyran (I) with N,N‐(dimethyl)trimethylsilylamine (II) in the presence of aluminum chloride gives the chlorosilyl ether (III) and the ring contraction product (IV) instead of the expected β‐amino silyl ether.
ChemInform Abstract: The Synthesis, Structure, and Some Reactions of Sterically Hindered α‐Silylisoxazoles.
Authors: BORTH M. , BOWLES K. D. , SCHLICKSUPP L. , NATALE N. R.
Published: May 2016

Reaction of the isoxazoles (I) with butyllithium at ‐78°C, followed by coupling with the organosilyl chlorides (II) yields the 5‐silylmethylisoxazoles (III).
ChemInform Abstract: Nucleophilic Phosphorylation of N‐(α‐Chlorobenzyl)benzimidoyl Chloride with Trivalent Phosphorus Compounds.
Authors: SUVALOVA E. A. , CHUDAKOVA T. I. , ONYS'KO P. P. , SINITSA A. D.
Published: May 2016

In the phosphorylation reaction of the benzimidoyl chloride (II) with the phosphine (Ia), the phosphinite (Ib), or the phosphite (Id), the chlorine atom at the sp3 carbon atoms is substituted, yielding the phosphonium salt (III), the phosphine oxide (IVb), or the phosphonate (IVc).
ChemInform Abstract: Synthesis, Structure, and Redox Properties of New Dithiocarbamates Containing a Heteroaromatic Ring.
Authors: GOL'DFARB YA. L. , OSTAPENKO E. G. , VINOGRADOVA V. G. , ZVEREV A. N. , POLYAKOV A. V. , YANOVSKII A. I. , YUFIT D. S. , STRUCHKOV YU. T.
Published: May 2016

Reduction of the bisazomethines (I) yields bisfurfuryl‐ or bisthenylamine (II) which are coupled with carbon disulfide (III) in the presence of metal salts to give the dithiocarbamate complexes (IV) which are soluble in organic solvents.
ChemInform Abstract: Crystal Structure of N2H5Sn2F5.
Authors: VILMINOT S. , GRANIER W. , WAHBI H. , COT L.
Published: May 2016

The title compound crystallizes in the monoclinic system, space group P21/a with Z=4.
ChemInform Abstract: Ionic Transport Properties of the Solid Solutions Cd1‐xInxF2+x (I) and Cd1‐xBixF2+x (II).
Authors: LAGASSIE P. , GRANNEC J. , EL OMARI M. , REAU J.‐M.
Published: May 2016

The new solid solutions (I) with 0 ≤ x ≤ 0.14 and (II) with 0 ≤ x ≤ 0.35 are obtained by annealing mixtures of the binary fluorides at 750 and 600 °C, resp., for 12 hours.
ChemInform Abstract: Induced Magnetic Anisotropy in Iron‐Aluminum‐Carbon Alloys.
Authors: SZYMURA S.
Published: May 2016

Annealing under an externally applied tensile stress or a magnetic field induces a uniaxial magnetic anisotropy in the permanent magnetic alloy Fe‐7.91 wt.% Al‐1.98 wt.% C with the easy magnetization direction coinciding with the direction of the external force.
ChemInform Abstract: The System SnS‐Sb.
Authors: KURBANOVA R. D. , MOVSUM‐ZADE A. A. , ALLAZOV M. R.
Published: May 2016

The phase diagram of the title system is determined.
ChemInform Abstract: Effect of Molecular Structure on Stereoselectivity During the Hydrolysis of Diastereoisomeric Permethrinic Acid Esters.
Authors: SIMON K. , BOROS I. , BALOGH G. , HIDASI G. , FOGASSY E. , FAIGL F. , ACS M.
Published: May 2016

Alkaline hydrolysis of the trans‐ester (Ia) is twice as fast as the reaction of the cis‐isomer (IIa).
ChemInform Abstract: Methyl Trideuteriomethyl (E)‐(α‐Bromoarylidene)malonates: Simple Stereochemical Probes in Nucleophilic Vinylic Substitution near the Retention/Stereoconvergence Borderline.
Authors: RAPPOPORT Z. , GAZIT A.
Published: May 2016

The electrophilic title compounds (IVa) and (IVb), which are activated to vinylic substitution by two chemically identical but isotopically distinguishable COOMe groups, are prepared starting from the compounds (Ia)/(Ib) or (Ic)/(Id).
ChemInform Abstract: Samarium‐Promoted, Stereocontolled Cyclopropanation Reactions.
Authors: MOLANDER G. A. , ETTER J. B.
Published: May 2016

The allylic alcohols (I) are cyclopropanated with diiodomethane (II) in the presence of samarium or samarium amalgam, producing the cyclopropyl carbinols (III) and (IV).
ChemInform Abstract: Preparation of 3‐(2‐Oxocyclododecyl)propionitrile from Cyclododecanone and Acrylonitrile and Some of Its Conversions.
Authors: ZAKHARKIN L. I. , CHURILOVA I. M.
Published: May 2016

The title compound (III) is prepared in high yield by a novel one‐step procedure.
ChemInform Abstract: An Improved Synthesis of 2‐Methylbenz(a)anthracene.
Authors: DECK L. M. , DAUB G. H. , LEON A. A.
Published: May 2016

Acylation of anthracene (I) with methylsuccinic anhydride (II) gives the keto acid (IIIa).
ChemInform Abstract: Functionalization of 3,5,6‐Trialkyl‐4‐hydroxy‐2‐pyrones in the 6‐α Position.
Authors: KOESTER G. + , HOFFMANN R. W.
Published: May 2016

The improved preparation of the pyrone (Va) starting from the diketone (I) is reported.
ChemInform Abstract: 1‐Methyl(benzyl)‐2,5‐dimethyl‐4‐N‐(aryl(alkyl)amino)piperidines and Their N‐Acyl Derivatives.
Authors: KYZNETSOV V. V. , GAIVORONSKAYA L. A. , FOMICHEV A. A. , ROMERO R. M. , PROSTAKOV N. S.
Published: May 2016

Boranate reduction of the azomethines (I) gives the 4‐aminopiperidines (II).
ChemInform Abstract: Syntheses of 1‐, 2‐, 3‐, and 4‐Acridinecarbaldehydes.
Authors: TAKAHASHI K. , CASTLE R. N. , LEE M. L.
Published: May 2016

The isomeric methylacridines (I) are brominated to give the bromomethylacridines (II) which are converted to the pyridinium salts (III).
ChemInform Abstract: The Synthesis of Monomethoxy(1)benzothieno(2,3‐c)quinolines.
Authors: CASTLE S. L. , BUCKHAULTS P. J. , BALDWIN L. J. , MCKENNEY J. D. JUN. , CASTLE R. N.
Published: May 2016

The cinnamic acids (I), prepared from the corresponding benzaldehydes, undergo ring closure with thionyl chloride in pyridine to give the 3‐chlorobenzothiophene‐2‐carboxylic chlorides (II) which react with the amines (III) to yield the amides (IV).
ChemInform Abstract: Synthesis and Reactions of Benzo(b)furo(2,3‐c)pyrylium Salts.
Authors: DULENKO V. I. , TOKUNOV S. V.
Published: May 2016

Cyclization of the acetonyl‐ and phenacylbenzofurans (I) with the aliphatic carboxylic anhydrides (II) in the presence of perchloric acid gives the pyrylium salts (III) which react with ammonia, producing the fused pyridines (IV).
ChemInform Abstract: Studies on Pyrimidine Derivatives. Part 39. Site‐Selectivity in the Reaction of 5‐Substituted and 4,5‐Disubstituted Pyrimidine N‐Oxides with Trimethylsilyl Cyanide.
Authors: YAMANAKA H. , SAKAMOTO T. , NISHIMURA S. , SAGI M.
Published: May 2016

Reaction of the substituted pyrimidine‐N‐oxides (I) with trimethylsilyl cyanide (II) leads to the formation of the pyridinecarbonitriles (III) and/or (IV).
ChemInform Abstract: Synthesis of Nitro and Amino N‐Heterocycles via Ring Transformation of 2‐Methyl‐3‐nitrochromone.
Authors: TAKAGI K. , TANAKA M. , MURAKAMI Y. , OGURA K. , ISHII K. , MORITA H. , AOTSUKA T.
Published: May 2016

Heating of 2‐methyl‐3‐nitrochromone (I) with various nitrogen‐containing compounds results in cleavage of the pyran ring, yielding 2‐hydroxyphenyl heterocycles.
ChemInform Abstract: Synthesis and Reactivity of Novel Bicyclic β‐Lactams.
Authors: PFAENDLER H. R. , STRASSER R.
Published: May 2016

The synthesis of the novel diazabicyclooctane carboxylates (I) starting from the readily available compound (II) (for (Ia), (Ib)) or (IX) (for (Ic)) is described.
ChemInform Abstract: Synthesis of 5‐Chloro‐5,8‐dideaza Analogues of Folic Acid and Aminopterin Targeted for Colon Adenocarcinoma.
Authors: HYNES J. B. , KUMAR A. , TOMAZIC A. , WASHTIEN W. L.
Published: May 2016

Coupling of the triaminoquinazoline (I) with ethyl p‐formylbenzoate (II) gives the anil (III) which is reduced to yield the ester (IVa).
ChemInform Abstract: Acidic Hydrolysis of 3‐(Aryl)‐2‐hydrazino‐4(3H)‐quinazolinones and 1‐Substituted 5(4H)‐s‐Triazolo(4,3‐a)quinazolinones.
Authors: SCHLEUDER M. , KOTTKE K. , KUEHMSTEDT H. + , SZKORUPA I.
Published: May 2016

Acidic hydrolysis of the hydrazinoquinazolinone (I) yields the compounds (II) ‐ (VI).
ChemInform Abstract: Chemistry of Amino Acid Thionoester Derivatives. An Unexpected Change in the Reaction Course between Heterocyclic‐2‐carboxylic Acid Hydrazides and N‐Substituted Thionoglycinates. Preferential Formation of 4‐Amino‐1,2,4‐triazole Adducts over 1,3,4‐Oxadiazole Products.
Authors: SIKORSKI J. A. , MISCHKE D. A. , SCHULTE B. J.
Published: May 2016

The N‐protected α‐amino thionoester (I) reacts with the aroyl hydrazides (IIa) and (IIb) to form the oxadiazoles (IIIa) and (IIIb).
ChemInform Abstract: On Triazoles. Part 7. Synthesis of Novel Tri‐ and Tetracyclic Ring Systems.
Authors: REITER J. , PONGO L. , KRAJCSI P. , ESSES‐REITER K. , SOHAR P. , MOLNAR H. , DVORTSAK P.
Published: May 2016

The 2‐(o‐nitrophenyl)‐3‐aminotriazoles (I) are converted to the diamino derivatives (II) which are cyclized with the orthoester (III) to give the tautomeric triazolobenzotriazepines (IV) and (V).
ChemInform Abstract: 2‐Aminoethoxyarsanes.
Authors: ASLANIDIS P. , KOBER F.
Published: May 2016

The arsanes (III) are obtained by reaction of the aminoarsanes (I) with ethanolamine (II).
ChemInform Abstract: Synthesis, Structure, and Reactivity of (Fe(dbt)(CO)2(Cp))(BF4) and Related S‐Bonded Thiophene Complexes.
Authors: GOODRICH J. D. , NICKIAS P. N. , SELEGUE J. P.
Published: May 2016

Displacement of isobutene from (I) by S‐ligands L (II) produces the complexes (III).
ChemInform Abstract: Synthesis, Characterization, and Reactivity of New Ruthenium and Osmium N2O2 Complexes.
Authors: MULLER J. G. , TAKEUCHI K. J.
Published: May 2016

The title complexes (IIIa)‐(IIId) are prepared in order to investigate further the effects that ligand systems may have on the stabilization of several oxidation states of Ru and Os complexes.
ChemInform Abstract: Heterobimetallic Au‐Ir, Ag‐Ir, and Au‐Ru Bis(μ‐hydrido) Complexes. X‐Ray Crystal and Molecular Structures of (AuRu(H)2(dppm)2(PPh3))PF6 and (Ir(H)2(bpy)(PPh3)2)PF6.
Authors: ALEXANDER B. D. , JOHNSON B. J. , JOHNSON S. M. , BOYLE P. D. , KANN N. C. , MUETING A. M. , PIGNOLET L. H.
Published: May 2016

Complex (III) (space group P21/n, Z=4) and (IVb) (space group P21/c, Z=4), which is obtained by anion metathesis from (IVa), are characterized structurally.
ChemInform Abstract: Binuclear Platinum(II) and ‐(III) Complexes of Pyridine‐2‐thiol and Its 4‐Methyl Analogue. Synthesis, Structure, and Electrochemistry.
Authors: UMAKOSHI K. , KINOSHITA I. , ICHIMURA A. , OOI S.
Published: May 2016

(IVb) is obtained with 0.5 mol CHCl3, (IVa) with two mol.
ChemInform Abstract: Iridoids. Part 22. Glucosidation of Hemiacetals Highly Stereoselective Synthesis of Iridoid Glucosides.
Authors: TIETZE L. F. , FISCHER R. , REMBERG G.
Published: May 2016

Reaction of the racemic iridoid aglucone acetates (Ia)‐(Id) with the glucopyranoside derivative (II) in the presence of trimethylsilyl trifluoromethanesulfonate in liquid SO2 followed by solvolysis gives nearly exclusively the β‐glucoside isomers (III) and (IV).
ChemInform Abstract: The Effect of Perchloric Acid on the Moessbauer Parameters of 119Sn in Frozen Solutions.
Authors: CHENG H. S. , HSU C. M. , CHEN M. Y. , LUH H.
Published: May 2016

The Moessbauer parameters of frozen solutions of 0.05 M Sn(H2O)(ClO4)2, Sn(H2O)2(ClO4)4, SnCl4·5 H2O, SnBr4, and Na2SnBr6 are found to be linearly related to the concentration of perchloric acid.
ChemInform Abstract: Phase Relations in the Systems Na2O‐M2O3‐V2O5 (M: Sc, Y, La).
Authors: KHODOS M. YA. , FOTIEV A. A.
Published: May 2016

The phase diagrams of the title systems are constructed for the subsolidus region.
ChemInform Abstract: Radiationless Deactivation of Singlet Oxygen (1δg) by Solvent Molecules.
Authors: SCHMIDT R. , BRAUER H.‐D.
Published: May 2016

Measurements of 1O2 lifetimes in several weakly deactivating solvents (e.g.
ChemInform Abstract: Synthesis, Structure and Optical Properties of NdPS4.
Authors: VOLODINA A. N. , KUVSHINOVA T. B. , MAKSIMOVA S. I. , MURAV'EV E. N. , NIYAZOV SH. A. , ORLOVSKII V. P. , PALKINA K. K. , CHIBISKOVA N. T.
Published: May 2016

The novel title compound is prepared from stoichiometric mixtures of Nd2S3 and P4S10 by heating at 700 °C and a pressure of 0.133 Pa for 65 h. An X‐ray analysis of a single crystal reveals that the title compound belongs to the space group I41/acd with Z=16.
ChemInform Abstract: Molecular Bridge Effects on Distant Charge Tunneling.
Authors: ONUCHIC J. N. , BERATAN D. N.
Published: May 2016

The question as to whether different hydrocarbon bridges should give different electron‐transfer rates is answered on the basis of energetic and topological (interference) effects gleaned from one‐electron models.
ChemInform Abstract: Diels‐Alder Reactions of 1,3‐Dienylboronates as a New Route to Functionalized Carbocycles.
Authors: VAULTIER M. , TRUCHET F. , CARBONI B. , HOFFMANN R. M. , DENNE I.
Published: May 2016

The enynes (I) are hydroborated with (II) to form the dienes (IIIa) (IIIc) which are converted to the dienylboronates (IIId) ‐ (IIIh).
ChemInform Abstract: 1H,1H‐Perfluoroalkylation of Enol Silyl Ethers with (1H,1H‐Perfluoroalkyl)‐phenyliodonium Triflates. A New Method for the Preparation of β‐ and δ‐Trifluoromethyl Carbonyl Compounds and Their Higher Perfluoroalkyl Homologues.
Authors: UMEMOTO T. , GOTOH Y.
Published: May 2016

The enol trimethylsilyl ethers (II) or (IV) react with the iodonium triflates (I) to give the β‐perfluoroalkyl carbonyl compounds (III) or (V).
ChemInform Abstract: Behaviour of Tetrahydrofurfuryl Halides Under Conditions of the Grignard Reaction.
Authors: KOCHETKOVA I. V. , BIRYUKOVA D. A. , ZAV'YALOV V. I. , KARAKHANOV R. A.
Published: May 2016

Preparation of the Grignard compounds from the furfuryl halides (I) and subsequent hydrolysis give the alcohols (II).
ChemInform Abstract: Chelation Controlled Regioselective Alkylation and 1,4‐Chirality Transfer in Optically Active 1‐Alkoxy‐1,4‐cyclohexadienes.
Authors: STANSSENS D. , DE KEUKELEIRE D. , VANDEWALLE M.
Published: May 2016

The chiral phenyl ethers (I) are reduced to form the 1,4‐cyclohexadienes (II).
ChemInform Abstract: Carbonyl Ylides as Intermediates in the Photochemical Reaction of Aromatic Ketones with Halo Ketene Acetals.
Authors: OOMS P. , HARTMANN W.
Published: May 2016

Photochemical coupling of the ketones (I) with the ketene acetals (II) yields the O‐heterocycles (III) ‐ (V).
ChemInform Abstract: Induction of Asymmetry by a Remote Chiral Center in the Amide Acetal Claisen Rearrangement.
Authors: WELCH J. T. , ESWARAKRISHNAN S.
Published: May 2016

Claisen rearrangement of the amide acetals derived from the prolinol derivative (I) and both the (E)‐ and (Z)‐alkenes (II) proceeds with relative and internal induction of asymmetry to give the amides (III) with an average relative asymmetric induction of 4.7:1.
ChemInform Abstract: Intramolecular Rearrangement with Ring Contraction of 1,4‐Dihydroxy‐3‐ bromo‐2,2,6,6‐tetramethylpiperidine.
Authors: KRINITSKAYA L. A. , ZAICHENKO N. L. , ROZYNOV B. V. , OSMANOVA S. R.
Published: May 2016

Alkaline treatment of the N‐hydroxypiperidine (Ia) gives the N‐hydroxypyrrolidine (II).
ChemInform Abstract: Addition of Phthalimidonitrene to Substituted N‐Benzenesulfonylindoles.
Authors: KUMAR P. R.
Published: May 2016

The reaction of the indoles (I) with phthalimidonitrene, generated in situ from the phthalimide (II), yields the aziridines (III) (no yield given for (IIIa)).
ChemInform Abstract: A Synthetic Approach to Benzo(1,2‐b:4,5‐b′)dipyrroles from Isoquinolines.
Authors: MEGHANI P. , STREET J. D. , JOULE J. A.
Published: May 2016

6,7‐Dimethoxy‐1‐methylisoquinoline (I) is converted into the dihydroisoquinoline (VIb) which undergoes cyclization, forming the benzodipyrrole derivative (VIIa).
ChemInform Abstract: Synthesis of Asymmetrically Substituted Aminohalogenobenzimidazoles.
Authors: CAMARASA M.‐J. , COE P. L. , JONES A. S. , WALKER R. T.
Published: May 2016

The nitration of the fluoroacetanilide (III) affords the products (I) or (IV) depending on the reaction temperatures.
ChemInform Abstract: N‐Nitration of 3‐Amino‐1,2,4‐triazole and Its Derivatives by Tetranitromethane and Pentaerythritol Tetranitrate.
Authors: MAYANTS A. G. , PYRESEVA K. G.
Published: May 2016

In the presence of the strong bases MOH (IV), the 3‐amino‐1,2,4‐triazoles (I), (VI) and (VIII) react with (III) or (V) to give the nitramine salts (II), (VII) and (IX).
ChemInform Abstract: Construction of Contiguous Quaternary and Tertiary Carbon Centres via the Asymmetric Michael Reaction.
Authors: TOMIOKA K. , YASUDA K. , KOGA K.
Published: May 2016

The β‐keto esters (I) are converted into the chiral lithioenamines (III) which are coupled with dimethyl ethylidenemalonate (IV) to produce the keto triesters (V) as the main products.
ChemInform Abstract: Reaction of Ketenes with N,N‐Disubstituted α‐Aminomethylene Ketones. Part 20. Synthesis of 2H‐Pyrano(2,3‐f)quinazoline Derivatives.
Authors: MOSTI L. , MENOZZI G. , SCHENONE P.
Published: May 2016

The hydroxymethylene ketones (I) react with the amines (II) to give the aminomethylene derivatives (III).
ChemInform Abstract: Pteridines. Part 84. Synthesis, Reactivity, and Properties of 1,3‐Dimethyllumazine‐6‐ and 7‐carboxaldehyde Derivatives.
Authors: KANG Y. , SOYKA R. , PFLEIDERER W.
Published: May 2016

5,6‐Diamino‐1,3‐dimethyluracil (I) couples with the oximes (II) to give the lumazines (IV) via the intermediates (III).
ChemInform Abstract: Preparation and Antibacterial Activity of 2‐Phenyl‐3‐(2,4‐diarylamino‐ s‐triazin‐6‐yl)‐5‐H/CH3/carboxymethyl‐4‐thiazolidinones and 2‐Aryl‐3‐ (p‐aminosulfophenyl/2‐pyrimidylaminosulfophenyl)‐p‐carboxymethyl‐4‐ thiazolidinones.
Authors: KAMDAR G. C. , CHAVDA A. C. , PARIKH A. R.
Published: May 2016

The title compounds (IV) and (VII) are synthesized as shown in the reaction scheme.
ChemInform Abstract: Tetracyclic Benzodiazepines. Part 3. Synthesis of the 2,3‐Dihydro‐1Hquino(1,8‐a)(1,5)benzodiazepine Ring System, and Derivatives of Potential Biological Interest.
Authors: GLAMKOWSKI E. J. , CHIANG Y.
Published: May 2016

Tetrahydroquinoline (I) reacts with the halogenides (II) to give the N‐substituted quinolines (III).
ChemInform Abstract: Reaction of 6,11‐Dihydrodibenzo(b,e)thiepin‐11‐carbonitrile with 1,2‐Dibromoethane, a Reinvestigation. Formation of 11,12‐Dihydro‐6H‐6,12‐methanodibenzo(b,f)thiocin‐12‐carbonitrile.
Authors: SINDELAR K. , BUDESINSKY M. , VANEK T. , HOLUBEK J. , SVATEK E. , MATOUSOVA O. , REES C. W. , PROTIVA M.
Published: May 2016

The compounds (IIIa) and (IV) are shown to be the products of the title reaction.
ChemInform Abstract: Synthesis and Properties of Partially Silylated Tri‐ and Tetraphosphanes. Reaction of Lithiated Diphosphanes with Chlorophosphanes.
Authors: FRITZ F. , VAAHS T.
Published: May 2016

In addition to the synthesis of triphosphanes via the cleavage of a Si‐P bond and formation of chlorinated diphosphanes a further access is pointed out starting from Li‐derivatives such as (I).
ChemInform Abstract: The Tungsten‐Tungsten Triple Bond. Part 14. Factors Influencing Triple Bonds Between Tungsten Atoms Having Valence Molecular Orbital Configurations of σ2π4 and π4δ2 and Preparation and Characterization of Bis(neopentyl)bis(acetato)bis(diethyldithiocarbamato)ditungsten.
Authors: CHISHOLM M. H. , CLARK D. L. , HUFFMAN J. C. , VAN DER SLUYS W. G.
Published: May 2016

Compounds having the general formula W2R2(O2CX)4 (R: an alkyl lacking β‐hydrogens; X: alkyl, aryl, NR2) adopt one of the two basic structures with W‐W triple bonds of approximate valence MO configurations of either π4δ2 (I) or σ2π4 (II).
ChemInform Abstract: Exceptional Efficacy of Some New Lacunar Dioxygen Carriers Based on Schiff Bases Derived from β‐Diketones and Triamines.
Authors: DELGADO R. , GLOGOWSKI M. W. , BUSCH D. H.
Published: May 2016

The new lacunar pentadentate Schiff base complexes (I) and (II) provide a protected cavity for O2 binding.
ChemInform Abstract: Structural Elucidation of New Diterpenoids Isolated from Rabdosia umbrosa var. leucantha f. Kameba.
Authors: TAKEDA Y. , ICHIHARA T. , TAKAISHI Y. , FUJITA T. , SHINGU T. , KUSANO G.
Published: May 2016

The terpenoids kamebakaurinin (I), kamebacetal A (II), kamebacetal B (III) and kamebakaurin (IVa) are isolated together with the known kamebanin (IVb).
ChemInform Abstract: The Br(CO)3Re Moiety. A Novel N‐Protecting Group in Peptide Synthesis.
Authors: IOGANSON A. A. , KOVALEV YU. G. , VOLKOV V. E.
Published: May 2016

The bromocarbonylrhenium amino acid complex (I) previously described reacts with the amino acid esters (II) using the carbodiimide method to give the dipeptide complexes (III).
ChemInform Abstract: Alkylation and Condensation Reactions of N,N‐Dibenzylglycine Ethers: Synthesis of α‐Amino Acid Derivatives.
Authors: GRAY B. D. , JEFFS P. W.
Published: May 2016

The α‐amino esters (I) are N‐dibenzylated and then coupled with the alkyl halides (IV) or the carbonyl compounds (VI) to give the α‐substituted carboxylates (V) and (VII).
ChemInform Abstract: Paramagnetic Resonance Evidence for Anion Fluctuations in the Paraelectric Phase of Potassium Dihydrogen Phosphate.
Authors: OWENS F. J.
Published: May 2016

In order to investigate the order‐disorder behavior of the anions, the phosphate anion in potassium dihydrogen phosphate has been replaced by the isostructural radical SeO43‐ and the temp. dependence of the EPR spectrum studied.
ChemInform Abstract: Mixed Donor Macrocyclic Ligands. Comparative X‐Ray Diffraction, IR, and Fast Atom Bombardment Mass Spectrometric Studies of the Nickel Thiocyanate Complexes of Three O2N3‐Donor Macrocycles.
Authors: ADAM K. R. , LEONG A. J. , LINDOY L. F. , MCCOOL B. J. , EKSTROM A. , LIEPA I. , HARDING P. A. , HENRICK K. , MCPARTLIN M. , TASKER P. A.
Published: May 2016

Minor changes in the substitution pattern of the backbone of the 17‐membered macrocyclic ring (I) incorporating O2N3 donor atoms have been demonstrated to have a significant influence on the ligand coordination modes in the corresponding Ni thiocyanate complexes of the type NiL(NCS)2·nH2O (L: (I); n: 0, 0.5, or 1).