bluuebunny/crossref_metadata_2025 huggingface dataset:
Deep Learning-based Predictive Model of mRNA Vaccine Deterioration: An Analysis of the Stanford COVID-19 mRNA Vaccine Dataset
Authors: Sulayman Nisreen
Published: August 2023

The emergence of SARS-CoV-2, the virus responsible for the COVID-19 pandemic, has resulted in a global health crisis leading to widespread illness, death, and daily life disruptions. Having a vaccine for COVID-19 is crucial to controlling the spread of the virus which will help to end the pandemic and restore normalcy to society. Messenger RNA (mRNA) molecules vaccine has led the way as the swift vaccine candidate for COVID-19, but it faces key probable restrictions including spontaneous deterioration. To address mRNA degradation issues, Stanford University academics and the Eterna community sponsored a Kaggle competition.This study aims to build a deep learning (DL) model which will predict deterioration rates at each base of the mRNA molecule. A sequence DL model based on a bidirectional gated recurrent unit (GRU) is implemented. The model is applied to the Stanford COVID-19 mRNA vaccine dataset to predict the mRNA sequences deterioration by predicting five reactivity values for every base in the sequence, namely reactivity values, deterioration rates at high pH, at high temperature, at high pH with Magnesium, and at high temperature with Magnesium. The Stanford COVID-19 mRNA vaccine dataset is split into the training set, validation set, and test set. The bidirectional GRU model minimizes the mean column wise root mean squared error (MCRMSE) of deterioration rates at each base of the mRNA sequence molecule with a value of 0.32086 for the test set which outperformed the winning models with a margin of (0.02112). This study would help other researchers better understand how to forecast mRNA sequence molecule properties to develop a stable COVID-19 vaccine.
Hepatocellular Carcinoma Prediction and early Diagnosis of Hepatitis B and C viral infection using miR-122 and miR-223 in a sample of Iraqi patients.
Authors: Al-Juboori Saja Khudhier Essa , Al-Juboori Shaymaa I K
Published: August 2023

Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related death. Therefore, it is critical for researchers to understand molecular biology in greater depth.  In several diseases including cancer, abnormal miRNA expression has been linked to apoptosis, proliferation, differentiation, and metastasis. Many miRNAs have been studied in relation to cancer, including miR-122, miR-223, and others. Hepatitis B and C viruses are the most important global risk factors for HCC. This study is intended to test whether serum miRNAs serve as a potential biomarker for both HCC and viral infections HBV and C. The expression of miRNA in 64 serum samples was analyzed by RT-qPCR. Compared to healthy volunteers, HCC patients' sera expressed significantly lower levels of miR-122 and miR-223. Furthermore, we compared the expression of these miRNAs between early-diagnosed HCC patients and healthy controls. There was a significant difference between miR-122 expression in HCC sera and healthy volunteers' sera (0.000 and 0.253, respectively), with a P value of <0.0001. Early diagnostic patients without treatment had completely deleted miR-122 expression levels, while those treated had slightly elevated levels. Clearly, miR-122 has been identified as a biomarker for early detection and follow-up of HCC treatment. HBV and HCV specimens expressed significantly lower levels of miRNA than normal samples with a P value of <0.0001. It is recommended that these findings be further investigated for diagnostic purposes. Further, these miRNAs are highly specific for diagnosing HCC, HBV, and HCV, making them valuable therapeutic indicators.
Komparasi Kemampuan Pemecahan Masalah Matematika antara yang Menggunakan dan Tidak Menggunakan Pembelajaran RME
Authors: Kurnia Hidayati Elin Sapto Rini;
Published: August 2023

Sentral dari pembelajaran matematika adalah kemampuan pemecahan masalah atau yang lebih mengutamakan proses dari hasil. Berdasarkan hal tersebut pembelajaran matematika seharusnya dikaitkan dengan dunia nyata dan pengalaman belajar yang pernah dialami oleh siswa. Salah satunya bisa dengan menerapkan pendekatan pembelajaran RME. Namun pada kenyatannya, dalam mengajar guru lebih sering menggunakan pembelajaran konvensional.

Penelitian ini bertujuan untuk (1) mengetahui kemampuan pemecahan masalah matematika yang menggunakan pembelajaran RME pada siswa kelas IV di MI Ma’arif Mayak Ponorogo, (2) mengetahui kemampuan pemecahan masalah matematika yang tidak menggunakan pembelajaran RME pada siswa kelas IV di MI Ma’arif Mayak Ponorogo, (3) mengetahui perbedaan kemampuan pemecahan masalah matematika antara yang menggunakan dan tidak menggunakan pembelajaran RME pada siswa kelas IV di MI Ma’arif Mayak Ponorogo.

Penelitian ini menggunakan pendekatan kuantitatif, dengan 2 variabel penelitian. Penelitian ini termasuk dalam penelitian jenis eksperimen dengan posttest control group design. Variabel bebas dalam penelitian ini adalah pembelajaran yang menggunakan RME dan pembelajaran yang tidak menggunakan RME, sedangkan variabel terikatnya adalah kemampuan pemecahan masalah matematika. Populasi dalam penelitian ini adalah siswa kelas IV di MI Ma’arif Mayak Ponorogo. Sampel penelitian ini diambil menggunakan teknik simple random sampling. Instrumen pengumpulan data menggunakan tes. Analisis data hasil penelitian ini menggunakan uji t (polled varians), karena data homogen.

Hasil dari penelitian diperoleh nilai rata-rata tes pada kelas kontrol = 46,72 dan rata-rata pada kelas eksperimen = 78,6. Hasil dari pengujian hipotesis pada pengujian nilai tes diperoleh hasil thitung > ttabel = 7,073 > 1,684. Dari pengolahan data dan pengujian hipotesis penelitian menunjukkan adanya perbedaan kemampuan pemecahan masalah matematika antara kelas kontrol dan kelas eksperimen yaitu ditunjukkan dengan nilai tes kelas eksperimen lebih tinggi dibandingkan dengan kelas kontrol dan juga berdasarkan pengujian hipotesis sehingga dapat disimpulkan bahwa terdapat perbedaan yang signifikan kemampuan pemecahan masalah matematika antara yang menggunakan dan tidak menggunakan pembelajaran RME
Pentingnya Pentingnya Pola Komunikasi Orang Tua dan Wali Kelas dalam Membangkitkan Motivasi Belajar Siswa melalui Kegiatan Paguyuban
Authors: Miftachul Choiri Widya Agustin Ningrum;
Published: August 2023

Pola komunikasi yang sehat, tanggap, dan aktif orang tua dan wali kelas sangat penting kaitannya dengan perkembangan siswa. Orang tua dapat mengetahui tumbuh kembang anak di rumah dan wali kelas dapat melihat tumbuh kembang siswa di sekolah. Dengan adanya kegiatan paguyuban orang tua dan wali kelas dapat mengkomunikasikan lebih jelas tentang perkembangan siswa untuk meningkatkan semangat belajar. Tujuan dari penelitian ialah untuk mengetahui pola komunikasi yang terjadi antara orang tua siswa dengan wali kelas, mengetahui kegiatan yang dilakukan untuk menjalin komunikasi lebih lanjut antara orang tua siswa dengan wali kelas dalam membangun motivasi belajar siswa, mengetahui dampak komunikasi antara orang tua siswa dengan wali kelas yang terjadi terhadap motivasi belajar siswa, dan mengetahui hambatan komunikasi yang terjadi antara orang tua siswa dengan wali kelas terhadap motivasi belajar siswa. Penelitian ini menggunakan pendekatan kualitatif dengan jenis penelitian studi kasus. Sumber data utama penelitian ini yakni kata-kata dan tindakan, selebihnya dokumentasi dan lain-lain. Penentuan informan dalam penelitian ini dilakukan dengan teknik purposive dan teknik snowball, dalam memperoleh data pada penelitian untuk pemilihan awal peneliti memilih orang tua, wali kelas yang memiliki anak didik kurang termotivasi dalam belajar. Hasilnya menunjukan bahwa motivasi belajar yang tumbuh dalam diri siswa-siswi sudah tampak. Hal ini tidak bisa dipisahkan dengan diadakannya berbagai jenis komunikasi yang sudah diterapkan antara orang tua dan wali kelas seperti pertemuan setiap bulan program paguyuban karena dalam kegiatan tersebut orang tua dengan wali kelas memiliki wadah setiap bulannya untuk mengetahui dan bertukar informasi tentang tumbuh kembang sang anak.
Analisis Kemampuan Pemecahan Masalah Matematika Pada Soal Cerita Berdasarkan Taksonomi Solo (Structured of Observed Learning Outcome) di SDN Kutuwetan Jetis Ponorogo
Authors: Widiasari Fitria , Hidayati Kurnia
Published: August 2023

Pentingnya kemampuan pemecahan masalah dalam proses pembelajaran, khususnya pada pembelajaran matematika. Penelitian ini bertujuan untuk mengetahui kemampuan pemecahan masalah matematika siswa kelas V SDN Kutuwetan ditinjau berdasarkan taksonomi SOLO. Penelitian ini merupakan penelitian kualitatif. Teknik analisis data menggunakan model Milles dan Hubermen yaitu (1) reduksi data; (2) penyajian data; dan (3) penarikan simpulan. Subjek penelitian ini berjumlah empat orang siswa yang diambil menggunakan teknik purposive sampling yang dikategorikan dalam tingkatan menurut taksonomi SOLO yaitu prestructural, unistructural, multistructural, relational, extended abstract. Namun pada penelitian ini subjek hanya mampu mencapai tingkatan relational. Hasil penelitian menunjukkan bahwa subjek A dengan level prestructural menunjukkan hanya mampu pada tahap memahami masalah dengan menggunakan sedikit informasi. Subjek B dengan level unistructural mampu memahami masalah dan merencanakan penyelesaian. Subjek C dengan level multistructural mampu memahami masalah, merencanakan masalah, serta mampu melaksanakan rencana tetapi masih terdapat kegagalan. Subjek D dengan level relational mampu memahami masalah, merencanakan masalah, serta mampu melaksanakan rencana dengan benar namun pada proses evaluasi subjek tidak melaksanakan sehingga mengalami kesalahan.
KREATIVITAS SISWA DALAM MEMANFAATKAN BARANG BEKAS SEBAGAI MEDIA PEMBELAJARAN SENI BUDAYA DAN KETERAMPILAN (SBK) KELAS V SDN KUTUKULON
Authors: Suryani Lilis , Susilowati Tintin
Published: August 2023

Tujuan dari penelitian ini ialah untuk menganalisis kreativitas siswa dalam memanfaatkan barang bekas sebagai media pembelajaran SBK, untuk mengetahui faktor yang mendorong keberhasilan keberhasilan siswa dalam memanfaatkan barang bekas sebagai media pembelajaran SBK serta untuk mengetahui faktot yang menghambat keberhasilan siswa dalam memanfaatkan barang bekas sebagai media pembelajaran SBK. Penelitian ini menggunakan pendekatan kualitatif yang bersifat analisis deskriptif. Subjek penelitian dalam penelitian ini ialah guru dan siswa kelas V SDN Kutukulon, dan barng bekas sebagai media. Pada teknik pengumpulan data, peneliti menggunakan metode wawancara, observasi, dan dokumentasi. Teknik analisis data menggunakan teknik analisis kualitatif Miles, Huberman, dan Saldana, yang meliputi kondensasi, penyajian data, dan penarikan kesimpulan.

Dari hasil penelitian ini ditemukan bahwa: 1) Kreativitas siswa dalam memanfaatkan barang bekas sebagai media pembelajaran SBK dapat menghasilkan karya yang baru baik berupa gagasan maupun karya nyata yang relatif berbeda dengan karya sebelum-sebelumnya. Para siswa menghasilkan karya yang berbeda-beda dari segi ide maupun bentuknya. 2) Dalam berkarya tersebut ada beberapa faktor yang mendorong keberhasilan siswa dalam memanfaatkan barang bekas yakni siswa memiliki keinginan untuk mencoba hal yang baru dan bermanfaat dari barang bekas, kemudian dampingan serta dukungan dari orang tua dan dukungan serta motivasi dari lingkungan sekolah atau dari guru
Pola Asuh Orang Tua Tunggal Ayah (Single Father) dalam Menanamkan Karakter Disiplin Anak Usia Sekolah Dasar
Authors: Putri Puspa Arum  , Puspidalia Yuentie Sova
Published: August 2023

Abstrak

Selain menjalankan peran sebagai pencari nafkah, ayah juga mengasuh dalam pembentukan karakter. Ketidakhadiran seorang ibu membuat ayah kesulitan membagi waktu antara pekerjaan dan urusan rumah tangga termasuk dalam pengasuhan anak. Akibatnya, ayah tidak konsisten dalam pola pengasuhan, aturan yang berubah-ubah, kurang tegas dalam menanamkan karakter disiplin, dan juga emosi yang tidak stabil mempengaruhi perkembangan anak. Sehingga, anak menjadi kurang disiplin. Tujuan penelitian ini yaitu mendeskripsikan bentuk pola asuh dan upaya orang tua tunggal ayah (single father) dalam menanamkan karakter disiplin anak usia sekolah dasar di dusun Seweru, Kare, Madiun. Penelitian ini menggunakan pendekatan kualitatif dengan jenis studi kasus. Teknik pengumpulan data melalui observasi, wawancara, dan dokumentasi. Teknik analisis data menggunakan analisis yang dikemukakan oleh Miles dan Huberman meliputi teknik reduksi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian ini menunjukkan bahwa (1) pola asuh yang diterapkan oleh orang tua tunggal ayah (single father) di Dusun Seweru, Kare, Madiun dalam menanamkan karakter disiplin anak usia sekolah dasar yaitu pertama, pola asuh demokratis, pola asuh permisif, dan pola asuh situasional. (2) Upaya yang dilakukan oleh orang tua tunggal ayah (single father) di Dusun Seweru, Kare, Madiun dalam menanamkan karakter disiplin anak usia sekolah dasar, yaitu melalui pemberian teladan oleh orang tua, kebersamaan orang tua dalam merealisasikan aturan/nilai moral, menghayati dunia anak, pemberian aturan dan konsekuensi logis, mengontrol perilaku anak, pengajaran nilai agama sebagai dasar penanaman karakter disiplin.
Pengaruh Penerapan Model Pembelajaran Discovery Learning Terhadap Minat dan Kemampuan Siswa Dalam Pemecahan Masalah Matematika pada Materi Bnagun Datar Kelas IV SDN Ngrukem
Authors: Bela Zaiyuri Rani Haryuti  , Sofwan Hadi
Published: August 2023

Pentingnya model pembelajaran discovery learning terhadap minat dan kemampuan siswa dalam pemecahan masalah matematika. Penelitian ini bertujuan untuk mengetahui pengaruh dari penerapan model pembelajaran discovery learning terhadap minat dan kemampuan siswa dalam pemecahan masalah matematika pada materi bangun datar kelas IV SDN Ngrukem. Penelitian ini merupakan penelitian kuantitatif. Jenis penelitian yang digunakan dalam penelitian ini adalah Pre Eksperimental Desaign (non-design). Desain penelitian yang digunakan adalah one group pretest posttest design yakni didalamnya terdapat pretest sebelum diberikan perlakuan penerapan model pemeblajaran discovery learning dan posstest sesudah diberikan perlakuan peneran model pembelajaran discovery learning. Subjek pada penelitian ini adalah seluruh siswa kelas IV SDN Ngrukem, teknik pengambilan sampel yang digunakan adalah sampling jenuh. Berdasarkan hasil perhitungan dengan menggunakan uji T dan uji Manova terdapat pengaruh yang signifikan penerapan model pembelajaran discovery learning terhadap minat siswa pada materi bangun datar kelas IV SDN Ngrukem dengan nilai sig 0,004 < 0,05, terdapat pengaruh yang signifikan penerapan model pembelajaran discovery learning terhadap kemampuan siswa dalam pemecahan masalah matematika pada materi bangun datar kelas IV SDN Ngrukem dengan nilai sig 0,000 < 0,05 dan terdapat pengaruh yang signifikan penerapan model pembelajaran discovery learning terhadap minat dengan nilai sig 0,003 < 0,05 dan kemampuan siswa dalam pemecahan masalah matematika dengan nilai sig 0,000 < 0,05 pada materi bangun datar keals IV SDN Ngrukem. Maka dapat disimpulkan bahwa penerapan  model pembelajaran discovery learning ini berpengaruh terhadap minat dan kemampuan siswa dalam pemecahan masalah matematika pada materi bangun datar kelas IV SDN Ngrukem.
Upaya Guru Dalam Meningkatkan Pemahaman Fiqih Wanita Pada Materi Haid Bagi Siswi Kelas 4 MI Bahrul Ulum Buluh Krandegan Kebonsari Madiun
Authors: Alifvia Nurkasanah  , M. Fathurahman
Published: August 2023

Pembelajaran merupakan suatu proses untuk memahamkan siswa. Sehingga dalam pemahaman diperlukan adanya upaya. Namun dalam memudahkan pemahaman bagi siswa, guru pasti mempunyai kendala dalam memahamkan siswa. Pada saat ini siswi kelas 4 MI yang sudah ada mengalami haid, dikarenakan haid berhubungan langsung dengan thaharah yang merupakan syarat melakukan ibadah. Oleh karena itu, pentingnya pemahaman haid bagi seorang wanita. Penelitian ini bertujuan untuk mendeskripsikan upaya guru dalam meningkatkan pemahaman pembelajaran fiqih wanita pada materi haid siswi kelas 4 dan hasil dalam meningkatkan pemahaman fiqih wanita pada materi haid siswi kelas 4 di MI Bahrul Ulum. Penelitian ini termasuk dalam penelitian kualitatif. Teknik pengumpulan data menggunakan metode wawancara, observasi, dan dokumentasi. Hasil penelitian dapat disimpulkan bahwa guru berupaya dalam merencanakan pembelajaran dengan menyusun rencana pembelajaran terkait dengan metode, strategi materi pembelajaran. Upaya dalam proses pembelajaran, menggunakan metode pembelajaran. Guru juga menggunakan materi tambahan yang berupa diktat. Dalam diktat terdapat materi mengenai fiqih wanita diantaranya bagaimana bersuci dari hadas besar, batasan aurat wanita. Upaya guru memotivasi siswa, upaya dalam membimbing siswa, upaya dalam evaluasi. Hasil dari diadakannya upaya guru dibuktikan dengan meningkatnya hasil evaluasi melalui nilai siswa dengan predikat baik, kesadaran dalam melakukan larangan ibadah saat mengalami haid yaitu dengan tidak memasuki area masjid, dan mengetahui batasan aurat seorang wanita. Dengan hasil tersebut dapat dikatakan peningkatan pemahaman siswa mengenai fiqih wanita tentang haid meningkat
Analisis Kompetensi Profesional dan Kepribadian Guru Pada Film Serdadu Kumbang
Authors: Sendyta Meilani  , Weni Tria Anugrah Putri
Published: August 2023

Pendidikan merupakan proses pengubahan sikap dan perilaku seseorang atau kelompok orang. Film Serdadu Kumbang merupakan film yang tepat untuk dijadikan panutan menjadi guru yang baik dan profesional. Penelitian ini bertujuan untuk (1) mendeskripsikan kompetensi professional guru dalam aspek pengelolaan kelas dan penggunaan media pembelajaran dalam film serdadu kumbang, (2) mendeskripsikan kompetensi professional guru dalam kehidupan sehari-hari, (3) mendeskripsikan kompetensi kepribadian guru dalam aspek interaksi yang bersifat mengayomi peserta didik dan memiliki sikap yang baik dalam film serdadu kumbang, (4) mendeskripsikan kompetensi kepribadian guru dalam kehidupan sehari-hari, (5) mendeskripsikan kompetensi kepribadian guru dalam berpenampilan dewasa sebagai pendidik yang layak diteladani dalam film serdadu kumbang. Data penelitian ini diperoleh dengan menggunakan pendekatan penelitian study kepustakaan (libbrary research) dengan tehnik analisi isi (content analysis). Hasil penelitian ini menunjukkan bahwa (1) terdapat kompetensi professional guru dalam aspek pengelolaan kelas secara humanis yakni mampu menyampaikan materi dengan baik serta mampu mengelola kelas dan penggunaan media pembelajaran yang tepat sehingga membuat siswa nyaman dalam belajar. (2) Dalam kesehariannya guru juga bersikap baik di lingkungan masyarakat. (3) Kompetensi professional guru dalam sehari-hari secara humanis mampu mengajar, mendidik dan mempunyai wawasan yang luas adalah dengan mengajar dan mendidik siswa dengan penuh kasih sayang dan memusatkan siswa pada proses pembelajaran.(4) Kompetensi kepribadian guru dalam memiliki sikap baik juga diterapkan dalam film serdadu kumbang secara humanis dengan bersikap demokratis, sabar dalam menjalani profesinya sebagai guru dan mengembangkan dirinya. (5) Terdapat cara berpakaian guru yang humanis adalah memberikan contoh sebgai panutan peserta didik dalam beretika dan berpakaian secara baik dan benar sesuaai aturan yang telah di tetapkan.
RELEVANSI NILAI KARAKTER TANGGUNG JAWAB PADA FILM NANTI KITA CERITA TENTANG HARI INI KARYA ANGGA DWIMAS SASONGKO DENGAN KEPRIBADIAN ANAK USIA SEKOLAH DASAR
Authors: Sherin Permatasari  , Farida Yufarlina Rosita
Published: August 2023

Film Nanti Kita Cerita Tentang Hari Ini adalah salah satu film nasional yang di dalamnya terdapat nilai karakter yang dimiliki setiap pemain. Nilai karakter ini muncul karena film ini bercerita mengenai problematika antaranggota keluarga dan perjuangan para tokoh untuk menyelesaikan konfliknya. Hal ini memunculkan banyak dialog yang mengandung unsur kata yang menunjukkan karakter seseorang. Tujuan penulisan ini adalah untuk menjelaskan relevansi nilai karakter tanggung jawab dengan kepribadian anak usia sekolah dasar. Penelitian ini adalah penelitian kepustakaan. Data dalam penelitian ini adalah dialog yang terdapat dalam film Nanti Kita Cerita Tentang Hari Ini. Adapun teknik pengumpulan data menggunakan literer atau documenter dan teknik analisis data menggunakan teknik analisis isi (content analysis). Berdasarkan hasil analisis penelitian, ditunjukkan bahwa terdapat nilai karakter tanggung jawab dalam film Nanti Kita Cerita Tentang Hari Ini yang relevan dengan kepribadian anak usia sekolah dasar
KOMPARASI MOTIVASI BELAJAR IPA BERDASARKAN PENERAPAN MODEL PEMBELAJARAN EXAMPLE NON EXAMPLE BERBANTUAN MEDIA MIND MAPPING PADA SISWA KELAS IV DI MI MA’ARIF NGRUPIT JENANGAN PONOROGO TAHUN AJARAN 2021/2022
Authors: Ardiyana Trining Tiyas  , Anis Afifah
Published: August 2023

Pembelajaran IPA yang dilakukan di kelas IV MI Ma’arif Ngrupit diketahui adanya motivasi belajar siswa yang rendah. Salah satu faktornya yaitu belum adanya penerapan model pembelajaran yang inovatif. Dalam penelitian ini peneliti menggunakan model pembelajaran Example Non Example berbantuan media Mind Mapping. Model dan media yang digunakan bertujuan agar pembelajaran yang dilakukan terkesan menarik sehingga dapat memacu motivasi siswa untuk belajar. Tujuan penelitian ini adalah untuk mengetahui bagaimana motivasi belajar siswa yang menggunakan dan tanpa menggunakan model pembelajaran Example Non Example berbantuan media Mind Mapping, serta mengetahui ada tidaknya perbedaan motivasi belajar siswa secara signifikan antara yang menggunakan dengan tanpa menggunakan model pembelajaran Example Non Example berbantuan media Mind Mapping. Metode yang digunakan adalah kuantitatif eksperimen, dengan sampel sejumlah 51 siswa. Sampel tersebut berasal dari dua kelas yaitu kelas IV A dengan jumlah 25 siswa sebagai kelas kontrol dan kelas IV B dengan jumlah 26 siswa sebagai kelas eksperimen. Hasil pada penelitian ini menunjukkan motivasi belajar siswa yang menggunakan dan tanpa menggunakan model pembelajaran Example Non Example berbantuan media Mind Mapping memiliki kategori cukup. Analisis data penelitian ini menggunakan t-test uji beda dua mean independen. Hasilnya terdapat perbedaan motivasi belajar siswa antara kelas kontrol dan kelas eksperimen yang ditunjukkan dengan skor rata-rata posttest kelas eksperimen lebih tinggi dibandingkan kelas kontrol yaitu 107,00

> 95,00. Kemudian, berdasarkan pengujian hipotesis diketahui bahwa nilai t pada equal variances assumed adalah 4,337 dengan sig. 0,000, yang menunjukkan nilai sig. 0,000 < 0,05.
PERAN ORANG TUA DALAM PEMBINAAN KARAKTER DISIPLIN BELAJAR PASCA MASA PANDEMI PADA ANAK KELAS 2 MI AL-FAJAR KEDUNGGALAR NGAWI
Authors: Siti Nurhidayah  , Ika Rusdiana
Published: August 2023

Orang tua memiliki peran yang besar dalam diri seorang anak terutama dalam pendidikan  anak dan juga tidak terkecuali pada pembinaan karakter disiplin belajar pada anak, dikarenakan karakter disiplin tidak terbentuk secara instan maka tetap ada proses pembentukan disiplin belajar salah satunya yakni dengan adanya peran orang tua, karena peran orang tua sangat penting untuk tumbuh kembang anak terutama peran orangtua dirumah. Peran orangtua dirumah antara lain yakni sebagai motivator dan fasilitator bagi anak. Disiplin sendiri tidak dapat di bangun secara instan dibutuhkan proses yang panjang agar melekat kuat dalam diri seorang anak, oleh karena itu disiplin harus dilakukan sejak dini agar mereka belajar hal-hal baik utuk mempersiapkan di masa dewasa. penelitian ini bertujuan untuk menjelaskan peran orang tua sebagai motivator dan fasilitator dalam pembinaan karakter disiplin belajar. Penelitian ini menggunakan metode penelitian deskriptif  kualitatif yang terdiri dari tiga tahap. Hasil penelitian ini menunjukkan bahwa peran orang tua sebaga motivator diwujudkan dengan memberikan contoh yang baik kepada anak serta membimbing dan menasehati anak, sedangkan peran orang tua sebagai fasilitator diwujudkan dengan memberikan suasana nyaman untuk anak belajar dan mendampingi anak belajar dirumah
Constructing an Ecological System for College English Education Based on Artificial Intelligence and Environmental Responsibility
Authors: Anqi Dou , Li Wen
Published: August 2023

The use of data innovation has led to changes in people’s lifestyle and productivity, as well as in the mode of schooling and educating. As the application of data innovation in the field of schooling turns out to be increasingly extensive, there is a growing use of modern technology and methods of data presentation. This paper aims to promote an alternative language teaching mode in the PC network environment and support the ecological development of online language teaching. This paper proposes using educational environments to guide the integration of computer networks and foreign language courses, which can help address the imbalanced foundations and environmental disturbances in online language teaching. The principals and laws of schooling environment are utilized to create and improve a teaching model that can be environmentally adapted for online foreign language teaching. In the process of testing the teaching system, the experimental results demonstrate that the adaptive GA-BPNN algorithm converged in only 6 iterations with a smooth error sum of 0.19, which increased convergence speed by 76%. The mean sum of squared error was also reduced by 79%. The comparison shows that the adaptive GA-BPNN variant can quickly achieve global optimization.
The dynamic relationship between nuclear energy, CO2 emissions, and economic growth: evidence from the richest countries in Europe and Asia
Authors: Sharma Kshitiz , Bal Debi Prasad , Mohanty Seba
Published: August 2023

This study examines the dynamic relationship between the share of nuclear energy, growth in CO2 emissions, and GDP growth for the wealthiest countries of the two continents, Europe and Asia, from 1965 to 2021. The results from the SVAR model show a significant positive relationship between GDP growth and the growth of CO2 emissions in the case of all countries in the present study. However, this is important in the values of the coefficients obtained in the case of different countries of both continents. Further, it has been observed that the relationship between the growth of nuclear energy and the growth in CO2 emissions is more complex and varies from country to country. The results specify a strong negative relationship between nuclear energy and CO2 emissions among France, Russia, the United Kingdom, and India. At the same time, there is no significant relationship between Germany, Italy, and China. Finally, the result shows no significant relationship between the growth in the share of nuclear energy and the GDP growth rate. From the policy perspective, this study suggests that alternative energy sources like nuclear energy are better for creating a healthy environment.
Antipsychotic medication non-adherence and factors associated among patients with schizophrenia in eastern Ethiopia
Authors: Mohammed Fethia , Geda Biftu , Yadeta Tesfaye Assebe , Dessie Yadeta
Published: August 2023

Background
Given that antipsychotic medication is a cornerstone for treating and preventing relapse in people with schizophrenia, non-adherence has been indicated as a big challenge. This study aimed to assess antipsychotic medication non-adherence and factors associated among patients with schizophrenia in eastern Ethiopia
Methods
We conducted an institution-based cross-sectional study in two public hospitals in Eastern Ethiopia from December 1, 2022, to January 31, 2023. Antipsychotic medication adherence was assessed using MOrisky medication adherence rating scale questionnaire, and insight was measured using the self-report insight scale for Psychosis (ISP). Multiple stepwise logistic regression models with Adjusted Odds Ratio (AOR) and 95% confidence interval (CI) were applied to identify the factors. Statistical significance was considered at p-value ≤ 0.05.
Results
We found that 44.57% of patients with schizophrenia experienced non-adherence to their antipsychotic medication. Being single (AOR = 2.48, 95% confidence interval [CI]:1.71, 3.58), alcohol users (AOR = 2.00, 95% confidence interval [CI]:1.46, 2.72), Khat chewers (AOR = 2.84, 95% confidence interval [CI]; 2.06, 3.90) and having no insight to their illness (AOR = 2.1, 95% confidence interval [CI]:1.52, 2.90) were more likely to be non-adherent to their antipsychotic medications
Conclusions
Non-adherence is a considerable burden among schizophrenia patients, and those who are single in their marital status, substance use short duration in their illness, are on multiple antipsychotic medications, and developing side effects require special attention at all steps of treatment levels caring process of such patients.
miR-let-7a inhibits sympathetic nerve remodelling after myocardial infarction by downregulating the expression of nerve growth factor
Authors: Jin Yanyan , （MS） Lei Qi , Zhang（MS） Xueli , Zheng（MS） Lu , Yang Peijin , Wan Kang , Wan Yu , Tan（MS） Jiayu , Yi Jie , Sh Yugen , Y Qingxia , Ya Suhua
Published: August 2023

Objective
Sympathetic hyperinnervation following myocardial infarction (MI) is a one of the primary causes of ventricular arrhythmias (VAs) after MI. Nerve growth factor (NGF) is a key molecule that induces sympathetic nerve remodelling. Previous studies have confirmed that microRNA (miR)-let-7a interacts with NGF. However, whether miR-let-7a is involved in sympathetic remodelling after MI remains unknown. Our aim was to investigate whether miR-let-7a was associated with the occurrence of VA after MI.
Methods and Results
A rat model of myocardial infarction was established using left coronary artery ligation. miR-let-7a expression levels were analysed by reverse transcription-quantitative PCR. Western blotting was also used to examine NGF expression levels in vivo and in M1 macrophages in vitro. The relationship between miR-let-7a and NGF levels was investigated using a luciferase reporter assay. The results revealed that the expression of miR-let-7a decreased significantly after MI, while NGF expression was significantly upregulated. In addition, overexpression of miR-let-7a effectively inhibited NGF expression in rats, which was also verified in M1 macrophages. Tyrosine hydroxylase and growth-associated protein 43 immunofluorescence results revealed that the administration of a miR-let-7a overexpression lentivirus to rats inhibited sympathetic remodelling after MI. Programmed electrical stimulation, renal sympathetic nerve activity recording, and heart rate variability measurements showed that miR-let-7a overexpression decreased sympathetic activity.
Conclusions
These findings provide novel insights into the molecular mechanisms by which miR-let-7a and NGF contribute to the progression of sympathetic nerve remodelling after MI. Therefore, miR-let-7a may be a promising therapeutic target to reduce the incidence of arrhythmia following MI.
Practical Guidelines for the Orthoplastic Approach: A Systematic Review of High-Quality Evidence for the Lower Extremity Trauma
Authors: Amendola Francesco , Cottone Giuseppe , Alessandri-Bonetti Mario , Carbonaro Riccardo , Innocenti Marco , Chen Hung-Chi , serror kevin , Vaienti Luca
Published: August 2023

Background: The aim of this review is to produce a high-quality evidence-based protocol for lower extremity traumas, from the immediate wound management to the final reconstruction, summarizing only the high-quality evidence present in literature.
Methods: Pubmed, EMBASE and Cochrane libraries were searched for high-quality studies on the orthoplastic approach for lower limb traumas. Search terms were: “trauma” OR “fracture”, “lower extremity” OR “lower limb” OR “leg” OR “tibia” OR “fibula”, “bone infection” OR “osteomyelitis”, “orthoplastic”, “flap” OR “reconstruction”. Inclusion criteria were cohort study, clinical trial, randomized controlled trial, systematic review or meta-analysis; lower extremity open fractures; detailed reports about patient and treatment; defined follow-up and outcomes. The PRISMA statement was followed. Exclusion criteria were diabetic foot, open fractures of the foot, not clearly defined protocol of treatment, case series and case reports. Three independent authors (MAB, GC and RC) searched the literature and extracted data from studies, based on eligibility criteria.
Results: We summarized the available evidence in three main time settings: fracture management in the emergency department; optimal management during the first 24 hours; optimal management and final goal within 72 hours.
Conclusions: The optimal goal is to achieve bone fixation and definitive coverage in a single surgery within 24 hours from injury. If not possible, the main purpose of the orthoplastic team should be the definitive coverage within 72 hours. A dedicated operating room and efficient referral to a specialized trauma center are paramount to reduce infection and costs.
Level of evidence: Level II, therapeutic study
Occurrence of Cryptosporidium in human stool samples in Qatar
Authors: Sabooni Sallama , Salah Husam , Singh Rajvir , Al-Qadi Khloud , Taj-Aldeen Saad J. , Ibrahim Emad
Published: August 2023

Background Cryptosporidium is a common pathogenic parasite known to cause diarrhea in humans, particularly young children living in poor-resource settings, as well as animals. Symptoms are usually mild in immunocompetent individuals and may progress to a life-threatening disease among immunocompromised patients. The diagnosis of cryptosporidiosis can be challenging due to insensitive conventional diagnostic tests. This study aimed to investigate the prevalence of cryptosporidiosis infection in Qatar and to compare four different diagnostic methods for detection of Cryptosporidium in human stool samples.Methods Stool samples obtained from patients with various gastrointestinal symptoms were received at the microbiology laboratory of Hamad general hospital, Qatar, for ova and parasites examination over a period of two years (January 2018 to December 2019). Stool samples were tested using four diagnostic methods: routine microscopy, immunochromatography (ICT), multiplex polymerase chain reaction (PCR), and modified Kinyoun's acid fast stain (MKS).Results Out of 205 stool samples, we detected Cryptosporidium in 17.6%, 15.0%, 7.0%, and 6.0% of specimens using PCR, ICT, MKS, and routine microscopy, respectively. Among the 36 positive patients, 39.0⁒ patients were under five years old, 17.0⁒ were aged between five and 10 years, 19.0⁒ were between 10 and 20 years, 17.0⁒ were between 20 and 40, and 8.0⁒ were over 40 years old. OF the positive cases, 61.1⁒ patients were male and 38.9⁒ were female. Additionally, 61.1⁒ of patients were Qatari nationals, while 38.9⁒ were from other origins.Conclusions For a better diagnosis of Cryptosporidium infection, PCR or ICT techniques should be incorporated alongside conventional microscopy methods. Future research using multi-locus sequence typing will to provide valuable insight to the molecular epidemiology and species diversity of Cryptosporidium species in Qatar.
Fintech, Green Imports, Technology, and FDI Inflow: Their Role in CO2 Emissions Reduction and the Path to COP26 - A Comparative Analysis of China
Authors: Guo Qi , Yin Chengyuan
Published: August 2023

Using a Nonlinear Autoregressive Distributed Lag (NARDL) model, this study investigates the relationships among CO2 emissions, green energy imports, foreign direct investment (FDI) inflow, and financial technology (Fintech) in China. The study considers both short- and long-term asymmetries, reflecting both the positive and negative effects of the variables of interests on CO2 emissions. Results reveal that both green technology and fintech significantly increase CO2 emissions for both positive and negative shocks. In contrast, FDI inflows have conflicting outcomes, being positively beneficial during positive shocks and adversely significant during negative shocks. Furthermore, green energy imports result in a considerable rise in CO2 emissions during negative shocks. These findings emphasize the necessity of taking economic factors into consideration when developing environmental regulations. Under COP26 aims to build a greener, more sustainable future for China, policy recommendations include fostering sustainable Fintech innovation, investing in green technology research, bolstering renewable energy imports, and improving climate legislation.
Intention to Use Personal Health Record System and Its Predictors Among Chronic Patients Enrolled at Public Hospitals in Bahir Dar City, Northwest Ethiopia: Using Modified UTAUT-2 Model
Authors: Abebe Solomon Abuhay , Endehabtu Berhanu Fikadie , Walle Agmasie Damtew , Hailu Debela Tsegaye , Gashu Kassahun Dessie
Published: August 2023

Introduction: Chronic diseases are the leading causes of death in the world. In sub-Saharan Africa, it leads to more mortality than almost every other region in the world. Currently, digital health technology like personal health records plays a crucial role in managing patients with chronic diseases. In low-resource countries like Ethiopia, it is uncertain how many chronic patients intend to use PHRs and the accompanying circumstances. Hence, the aim of this study was to assess chronic patients’ intention to use PHRs and its predictors enrolled in public health hospitals in Bahir Dar City, northwest Ethiopia.
Method: An institutional-based cross-sectional study was conducted among 924 respondents from April 5 to May 9, 2023, in Bahir-Dar city public hospitals. A stratified sampling technique followed by a systematic sampling technique was applied to select the study participants. An interviewer-administrated questionnaire was conducted using Kobo Collect. A UTAUT2 model was applied to develop theoretical frameworks. SPSS version 25 software was used to estimate the descriptive statistics, and the structural equation model analysis was used to evaluate model constructs using AMOS version 21 software.
Results: In this study, a total of 908 study subjects participated. The proportion of chronic patients’ intention to use PHR was 46.7% (95.0% CI (43.4-50.1)). According to the findings, performance expectancy (β=0.259, p-value<0.001), effort expectancy (β=0.214, p-value<0.001), social influence (β=0.174, p-value<0.001), and facilitating condition (β=0.114, p-value<0.01) had a significant effect on the intention to use PHRs.
Conclusion: Generally, the overall intention to use PHR was low. Our finding illustrates that the effects of performance expectancy, effort expectancy, social influence, and facilitating conditions had a positive effect on patients’ intentions to use PHRs. The effect of effort expectancy on the intention to use a PHR was positively moderated by age. In addition, implementers should focus on improving patient capacity, motivating users, and raising awareness regarding PHR.
Assessment of Current Practices and Emerging Trends: A Pilot Survey of the Thyroid Disease Committee of the Sichuan Medical Association
Authors: Zhang Sicheng , Zeng Dingfen , Shui Chunyan , Li Chao
Published: August 2023

Background
The Thyroid Disease Committee of the Sichuan Medical Association (TDCSMA) conducted a periodic survey to assess the current state of thyroid-related treatment practices in Sichuan Province.
Methods
A comprehensive 40-question survey was distributed to 44 thyroid-related departments across the hospitals in Sichuan province. Data collection took place from June 15th to June 30th.
Results
The hospitals surveyed are mainly situated in the eastern plains of Sichuan. Of these hospitals, 52.27% have 31–60 beds, and 54.55% of the departments are staffed by 5–10 doctors. Most doctors were born between 1990 and 2000. In terms of specialization, 75% of the surveyed departments have doctors majored in thyroid and breast, 47.73% in general surgery, and 6.82% each in otolaryngology and vascular surgery. The survey respondents have diverse years of training before entering practice: 27.27% have 2–3 years, 31.82% have 3–4 years, and 20.45% have 4–5 years. Thyroid cancer accounts for 100% of the responses, followed by thyroid adenoma (90.91%) and thyroid cyst (81.82%). Regarding thyroid surgery, 54.54% of the departments perform 100–500 open thyroid surgeries annually, and 72.73% conduct more than 10 endoscopic-assisted thyroid surgeries each year. With the implementation of China's medical insurance reform in 2023, 52.27% of the hospitals adjust prices for thyroid surgery. Additionally, 52.27% of the departments report that their doctors work over 50 hours per week, and the overall career satisfaction rate is 75% (very satisfied or satisfied). Moreover, 34.09% of department heads report a decrease in average patient intake from 2020 to 2023, while the operative volume increased for 72.73% of the surveyed departments in the past 12 months.
Conclusions
The data provides a comprehensive and current overview of the thyroid-related departments, covering medical status, disease distribution, case and operative volume, and career satisfaction. The findings indicate a relative imbalance in the allocation of medical resources for thyroid diseases within Sichuan Province.
Self-perceptions’ knowledge, training, management and personal experience in psychiatric emergencies according to work experience: an explorative study among Italian nurses employed in the Emergency Departments
Authors: Chang Yun-Chen , Mea Rocco , Vitale Elsa
Published: August 2023

Background: In Italy, the number of incoming arrives in Emergency Departments (ED) that include psychiatric patients has significantly increased. To assess how ED nurses perceived their self-perceptions’ knowledge, the arguments of the greatest interest in the training and management of psychiatric emergencies and also personal experience in emergency psychiatric patients according to both nursing educational levels and work experience.
Methods: An observational, cohort, cross-sectional and multicenter study was conducted from August to September 2022.
Results: This study was completed with 413 Italian nurses surveyed. Knowledge in psychiatric emergency conditions was important for an emergency nurse (t=2.444, p=.015), and nurses considered as important current knowledge on issues of relevant to emergency psychiatry (t=3.516, p<.001). Significant associations were assessed between: nursing educational level and psychiatric aggressions received (t=-2.675, p=0.008) and arguments of interactions with psychiatric drugs (t=-2.106; p=0.036); with the hypochondriacally anxiety (t=-2.274; p=0.024); the hallucinated patients (t=2858; p=0.004); the use of counseling in psychiatric wards (t=1.555, p=0.121). Significant associations were recorded between work experience and pharmacological management of the psychiatric patients (t=-3.035; p=.003); psychiatric drugs in emergency (t=2.758; p=.006); medico-legal aspects in psychiatric emergencies (t=2.554; p=.011); the management of negative experiences of the multidisciplinary team towards the patient (t=-2.684; p=.008); patients who simulated (t=-2.138; p=.033).
Conclusions: ED nurses required to perform their knowledge to identify the psychological and the physical signs and symptoms of psychological distress as well as the skills to provide appropriate care at the EDs, by improving nurses’ competencies to recognize and manage psychiatric patients.
Explaining the resources wastage and its underlying factors in COVID-19 management in Iran: A qualitative study
Authors: vatandoost vahid , barooni mohsen , Tabatabaee Seyed Saeed , Okhovati maryam
Published: August 2023

Background:
Identifying factors affecting health costs can be useful in determining the best policies for controlling and managing health costs. To this end, the present study aimed to analyze resource wastage and identify factors underlying it in COVID-19 management in the Iranian health sector.
Method:
This qualitative content analysis study was conducted in the Iranian health sector. The participants were 23 senior, middle, and operational managers in the health sector. The data were collected through semi-structured interviews with the managers. The participants were selected using purposive, quota, and snowball sampling techniques. The interviews continued until the data were saturated. The collected data were analyzed using MAXQDA software (version 10).
Results:
Following the data analysis, the factors affecting the wastage of health resources were divided into 4 categories and 9 subcategories. Vaccines, diagnostic kits, medicines, and human resources were the main factors underlying resource wastage. The identified subcategories were open and unused vials, nonuse of distributed vaccines and their expiration, excess supply and decreased demand for vaccines, expiration of diagnostic and laboratory kits and their quantitative and qualitative defects, the large number of tests, non-organization of medical staff, and the inefficiency and expiration of medicines.
Conclusion:
Given the limited health funds and the increased healthcare costs, effective preparation and planning and making reasonable decisions for unexpected events can minimize unnecessary costs and resource wastage, which requires some revisions in attitudes toward COVID-19 management in the healthcare sector.
WITHDRAWN: An Extension of the Geometric G Family of Probability Distributions with Statistical Properties, Copulas and Modeling Real-life Data Sets
Authors: Hashem Atef F. , Abdelkawy M. A. , Muse Abdisalam Hassan , Yousof Haitham M.
Published: August 2023

A novel compounded two-parameters-G family of continuous probability distributions is presented here thanks to this body of work. Calculations are done to determine and examine the pertinent mathematical properties. There is a dedicated focus on the typical reciprocal-Weibull baseline model both mathematically and statistically in one of the special parts. We used the copula method to generate a number of bivariate and multivariate distributions. These new distributions will be useful for modeling bivariate and multivariate data. The new compounded two-parameters-G family's applicability and flexibility are demonstrated by means of three applications to real-world data sets. These examples prove the family's applicability.
Genome-wide investigation of the TGF-β superfamily in scallops
Authors: Zhang Qian , Chen Jianming , Wang Wei
Published: August 2023

Background
Transforming growth factor β (TGF-β) superfamily genes can regulate various processes, especially in embryogenesis and adult development and homeostasis. To understand the evolution and divergence patterns of the TGF-β superfamily in scallops, genome-wide data from the Bay scallop (Argopecten irradians), the Zhikong scallop (Chlamys farreri) and the Yesso scallop (Mizuhopecten yessoensis) were systematically analyzed using bioinformatics methods.
Results
Twelve members of the TGF-β superfamily were identified for each scallop. The phylogenetic tree supported that these genes were grouped into 11 clusters, including BMPs, ADMP, NODAL, GDF, activin/inhibin and AMH. The number of exons and the conserved motif showed some differences between different clusters, while genes in the same cluster showed a high degree of similarity. Selective pressure analysis showed that the TGF-β superfamily in scallops was evolutionarily conserved. The spatiotemporal expression profiles suggested that different TGF-β members have distinct functions. Several BMP-like and NODAL-like genes were highly expressed in early developmental stages, patterning the embryonic body plan. GDF8/11-like genes showed high expression in striated muscle and smooth muscle, suggesting that these genes may play a critical role in regulating muscle growth. Further analysis revealed a possible duplication of AMH, which played a key role in gonadal growth/maturation in scallops. In addition, this study found that several genes were involved in heat and hypoxia stress in scallops, providing new insight into the function of the TGF-β superfamily.
Conclusion
Characteristics of the TGF-β superfamily in scallops were identified, including sequence structure, phylogenetic relationships, and selection pressure. The expression profiles of these genes in different tissues, at different developmental stages and under different stresses were investigated. Generally, the current study lays a foundation for further study of their pleiotropic biological functions in scallops.