bluuebunny/crossref_metadata_2025 huggingface dataset:
Synthesis and Evaluation of Anticonvulsant Activity of Some
5,5-Disubstituted-N3-[(2-aryl thiazolidine-4-one-3-yl)amino]hydantoins
Authors: Rishipathak Dinesh , Vaidya Sushil , Ghodke Shantanu
Published: February 2023

According to the World Health Organization, the majority of people with epilepsy who live in developing
countries do not have access to high-quality treatment. Modern anticonvulsants are in high demand
since the unwanted effects of those compounds already in use make therapy difficult. The synthesis of
derivatives of 5,5-disubstituted-N3-[(2-aryl thiazolidine-4-one-3-yl)amino]hydantoins has been reported.
The position N3 of the hydantoin nucleus was substituted with 4-thiazolidinone moiety containing
aryl substituent at 2nd position with the goal of achieving the enhanced anticonvulsant effect.
Compounds 5c, 5d, 5l, 5r showed significant activity among the evaluated compounds compared to
control at dose of 45 mg/kg. The analysis of structural features revealed that the substitution of p-hydroxy
phenyl and cinnamyl substituted at 2nd position of thiazolidinone ring in 5,5-diphenyl-2,4-
imidazolidinedione and p-chloro phenyl, p-methoxy phenyl substituted at 2nd position of thiazolidinone
ring in (5,5-dialkyl)/(5-alkyl-5-substitutedphenyl)-2,4-imidazolidinedione skeleton enhanced the
anticonvulsant potentiality of the synthesized compounds.
Design, Synthesis, Anti-tubercular and Docking Studies of
Novel 2-Furanyl-3-substituted Quinazolin-4-one Derivatives
Authors: Kumarachari Rajasekhar Komarla , Guruvareddy Mayandigari , Phebe M. , Reddy Puttareddy Lokeswari , Nithin Marella Sai , Lakshmipathi Desingu , Manasa Maddali
Published: February 2023

In this work, the synthesis, characterization and the anti-tubercular activity of novel 2-furanyl-3-
substituted quinazolin-4-one derivatives and also predicted their affinity against Mycobacterium
tuberculosis enoyl acyl carrier protein reductase were carried out. The targeted compounds were
synthesized by the condensation of 2-(furan-2-yl)-4(3H)-1-benzoxazine-4-one with different primary
amines. After structural elucidation using spectral data, the compounds were screened for anti-tubercular
activity against Mycobacterium tuberculosis H37RV strain. The binding affinity against enoyl acyl
carrier protein reductase was predicted using MOE and FITTED docking tools. The synthesized
compounds showed a promising anti-tubercular activity in the range from 12.5 to 100 μg/mL. According
to MOE docking, the common amino acids in the active site of InhA were found to form hydrogen
bonding and hydrophobic interactions with the synthesized quinazolinones. Docking simulations also
showed that an aromatic side chain capable of forming hydrogen bond interactions can increase affinity
of 2-furanyl quinazolinones to enoyl acyl carrier protein reductase.
Casuistic cases of parathyroid carcinoma with a verified mutation in the MEN1 gene
Authors: Pylina S. V. , Kim E. I. , Bondarenko E. V. , Krupinova J. A. , Eremkina A. K. , Mokrysheva N. G.
Published: February 2023

Parathyroid cancer (PTC) is usually sporadic; however, it could be presented as a component of hereditary syndromes. The prevalence of PTC among patients with primary hyperparathyroidism (PHPT) is about 1% cases. The lack of reliable preoperative predictors significantly complicates the diagnosis of PTC. The clinical course is non-specific and in most cases is determined by severe hypercalcemia. The final diagnosis can only be made on the basis of invasive histopathologic features, while an analysis immunohistochemical (IHC) one can be used only as an additional method. Given the rarity the diagnosis of MEN1-related PTC a challenge. We present two clinical cases of patients with PTC and a verified heterozygous mutation in the MEN1 gene. The described cases demonstrate the complexity of morphological diagnosis for PTC, the heterogeneity of clinical manifestations in patients with the MEN1 mutation, as well as the need for timely screening to identify other components of MEN1 syndrome and mutations of the MEN1 gene among first-line relatives.
Cognitive and psychoemotional changes in menopausal transition: The possibility of medical correction
Authors: Gasparyan S. A. , Chotchaeva A. M. , Karpov S. M.
Published: February 2023

The increasing of older age group in the population determines studying of age related diseases and emergence of new investigations in this area. In Female body, entering the menopausal transition is the start of «aging» of reproductive function and linked with decreasing of sex hormons levels. A direct connection between changes of estrogen, progesterone, androgen ratios and cognitive function of women was revealed. The anatomical localization of sex hormone receptors, the mechanisms of interaction of hormones with these receptors determine the ways of implementing biological effects of steroids on the CNS. Modern theories of «healthy nerve cells» and «eu-estrogenemia» explains the role of additional criteria, such as the absence of neurological diseases history and the duration of hypoestrogenia, to the outcome of menopausal hormone therapy. Additional factors that can affect to MHT action include: the composition of hormone therapy, administration methods, regimens (cyclic, continuous), duration of treatment, history of endocrine diseases, diabetes mellitus, gynecological history (parity, menarche age, COC use), heredity. The sections present the effect of menopausal transition on the development of depression, mood changes, sleep disturbances and mental disabilities. The explanation of negative effects of menopausal hormone therapy to cognitive health is also described by modern point of view. The ambivalent opinions of researchers, the potential of new reading of the results of earlier studies, confirms the necessity of continuing study of this topic.
What newly brought endocrinology by the past 2022?
Authors: Melnichenko G. A. , Shestakova M. V.
Published: February 2023

In the past year, the Federal Project “Fight against Diabetes” 2023–2030 was developed in detail and submitted in detail and submitted to the Government of the Russian Federation, which will significantly improve the practice of working with patients with diabetes, providing them with maximum availability of medical care, including in updated and technologically re -equipped regional endocrinological centers, reviving the active work of “Diabetes schools”, “Diabetic foot” rooms, diagnostic laboratories, introducing new forms of communication with patients, including using personal assistants of a doctor, continuous technologies for monitoring glycemia, etc.
Tsunami: the world’s greatest waves, by James Goff and Walter Dudley, 2021. Oxford University Press, USA, 231 pages. Hardback: price 17.24$, ISBN 0197546129
Authors: Pleskot Krzysztof
Published: February 2023

No abstract available.
Error analysis of approximate operators for a particle method based on Voronoi diagram
Authors: Koba Hajime , Sato Kazuki
Published: February 2023

This paper considers several approximate operators used in a particle method based on a Voronoi diagram. We introduce and study our approximate operators on gradient and Laplace operators. We derive error estimates for these approximate operators by applying our weight functions. The key idea of deriving our error estimates is to divide the integration region into a ring-shaped area and some areas. In the appendix, we give an exemplary application of the main results of this paper.
A drug utilisation pattern in non-dialysis patients of diabetic nephropathy in a government-run tertiary care hospital in South-Asia
Authors: Seetharaman Rajmohan , Advani Manjari , Mali Smita , Pawar Sudhir
Published: February 2023

Objectives

The objective of the present study was to evaluate the Drug utilisation pattern in patients of diabetic nephropathy (stage 1–4) in a tertiary care hospital in South-Asia.

Methods

A cross-sectional observational study was conducted in the nephrology out-patient-department of a tertiary care hospital in South-Asia. WHO core prescribing, dispensing, and patient care indicators were evaluated, and adverse drug reactions (ADRs) encountered by the patients were analysed for causality, severity, preventability, and outcome.

Results

The most commonly prescribed antidiabetics in diabetic nephropathy patients were insulin (17.42%), followed by metformin (4.66%). Current drugs of choice SGLT-2 inhibitors were prescribed in a lesser frequency than expected. Loop diuretics and calcium channel blockers (CCBs) were the preferred antihypertensives. The use of ACE inhibitors (1.26%) and ARBs (3.45%) for hypertension was restricted to Stage 1 and 2 nephropathy. The patients were on 6.47 drugs on average. 30.70% of drugs were prescribed by generic names, 59.07% of the drugs were prescribed from the national essential drugs list and 34.03% of the prescribed drugs were supplied by the hospital. CTCAE grade 1 (68.60%) and grade 2 (22.09%) ADR severity was the highest.

Conclusions

Prescribing patterns in patients of diabetic nephropathy were adapted from relevant medical evidence, affordability and availability of the drugs. Generic prescribing, availability of drugs and ADR preventability in the hospital have a broad scope for improvement.
Robin–Dirichlet alternating iterative procedure for solving the Cauchy problem for Helmholtz equation in an unbounded domain
Authors: Achieng Pauline , Berntsson Fredrik , Kozlov Vladimir
Published: February 2023

We consider the Cauchy problem for the Helmholtz equation with a domain in

ℝ
d

{\mathbb{R}^{d}}

,

d
≥
2

{d\geq 2}

with N cylindrical outlets to infinity with bounded inclusions in

ℝ

d
-
1

.

{\mathbb{R}^{d-1}.}

Cauchy data are prescribed on the boundary of the bounded domains and the aim is to find solution on the unbounded part of the boundary.
In 1989, Kozlov and Maz’ya [14]
proposed an alternating iterative method for solving Cauchy problems associated with elliptic, self-adjoint and positive-definite operators in bounded domains. Different variants of this method for solving Cauchy problems associated with Helmholtz-type operators exists. We consider the variant proposed by Berntsson, Kozlov, Mpinganzima and Turesson (2018) [4]
for bounded domains and derive the necessary conditions for the convergence of the procedure in unbounded domains. For the numerical implementation, a finite difference method is used to solve the problem in a simple rectangular domain in

ℝ
2

{\mathbb{R}^{2}}

that represent a truncated infinite strip. The numerical results shows that by appropriate truncation of the domain and with appropriate choice of the Robin parameters

μ
0

{\mu_{0}}

and

μ
1

{\mu_{1}}

, the Robin–Dirichlet alternating iterative procedure is convergent.
A mollifier approach to regularize a Cauchy problem for the inhomogeneous Helmholtz equation
Authors: Maréchal Pierre , Simo Tao Lee Walter , Triki Faouzi
Published: February 2023

The Cauchy problem for the inhomogeneous Helmholtz equation with
non-uniform refraction index is considered. The ill-posedness of
this problem is tackled by means of the variational form of
mollification. This approach is proved to be consistent, and
the proposed numerical simulations are quite promising.
Stability of determination of Riemann surface from its DN-map in terms of holomorphic immersions
Authors: Belishev Mikhail I. , Korikov Dmitrii V.
Published: February 2023

Suppose that

(
M
,
g
)

{(M,g)}

is a compact Riemann surface with metric g
and boundary

∂
⁡
M

{\partial M}

, and Λ is its DN-map. Let

M
′

{M^{\prime}}

be diffeomorphic to M, let

∂
⁡
M

=

∂
⁡

M
′

{\partial M=\partial M^{\prime}}

and let

Λ
′

{\Lambda^{\prime}}

be the DN-map of

(

M
′

,

g
′

)

{(M^{\prime},g^{\prime})}

. Put

(

M
′

,

g
′

)

∈

𝕄
t

{(M^{\prime},g^{\prime})\in\mathbb{M}_{t}}

if

∥

Λ
′

-
Λ

∥

H
1

⁢

(

∂
⁡
M

)

→

L
2

⁢

(

∂
⁡
M

)

⩽
t

{\lVert\Lambda^{\prime}-\Lambda\rVert_{H^{1}(\partial M)\to L^{2}(\partial M)}%
\leqslant t}

holds.
We show that, for any holomorphic immersion

ℰ
:

M
→

ℂ
n

{\mathscr{E}:M\to\mathbb{C}^{n}}

(

n
⩾
1

{n\geqslant 1}

), the relation

sup

M
′

∈

𝕄
t

⁡

inf

ℰ
′

⁡

d
H

⁢

(

ℰ
′

⁢

(

M
′

)

,

ℰ
⁢

(
M
)

)

→

t
→
0

0

\sup_{M^{\prime}\in\mathbb{M}_{t}}\inf_{\mathscr{E}^{\prime}}d_{H}(\mathscr{E}%
^{\prime}(M^{\prime}),\mathscr{E}(M))\xrightarrow{t\to 0}0

holds, where

d
H

{d_{H}}

is the Hausdorff distance in

ℂ
n

{\mathbb{C}^{n}}

and
the infimum is taken over all holomorphic immersions

ℰ
′

:

M
′

↦

ℂ
n

{\mathscr{E}^{\prime}:M^{\prime}\mapsto\mathbb{C}^{n}}

. As it is known, Λ determines not the surface

(
M
,
g
)

{(M,g)}

but its conformal class

{

(
M
,

ρ
⁢
g

)

⁢

∣
ρ
>

⁢
0

,

ρ
|

∂
⁡
M

=
1

}

,

\bigl{\{}(M,\rho g)\mid\rho>0,\,\rho|_{\partial M}=1\bigr{\}},

while holomorphic immersions are determined by this class. In the mean time,

(
M
,
g
)

{(M,g)}

is conformally equivalent to

ℰ
⁢

(
M
)

{\mathscr{E}(M)}

,
and

(

M
′

,

g
′

)

{(M^{\prime},g^{\prime})}

is conformally equivalent to

ℰ
′

⁢

(

M
′

)

{\mathscr{E}^{\prime}(M^{\prime})}

.
Thus, the closeness of the surfaces

ℰ
′

⁢

(

M
′

)

{\mathscr{E}^{\prime}(M^{\prime})}

and

ℰ
⁢

(
M
)

{\mathscr{E}(M)}

in

ℂ
n

{\mathbb{C}^{n}}

reflects the closeness of the corresponding conformal classes for close DN-maps.
Inverse problems of identifying the unknown transverse shear force in the Euler–Bernoulli beam with Kelvin–Voigt damping
Authors: Kumarasamy Sakthivel , Hasanov Alemdar , Dileep Anjuna
Published: February 2023

In this paper, we study the inverse problems of determining the unknown transverse shear force

g
⁢

(
t
)

{g(t)}

in a system governed by the damped Euler–Bernoulli equation

ρ
⁢

(
x
)

⁢

u

t
⁢
t

+

μ
⁢

(
x
)

⁢

u
t

+

(

r
⁢

(
x
)

⁢

u

x
⁢
x

)

x
⁢
x

+

(

κ
⁢

(
x
)

⁢

u

x
⁢
x
⁢
t

)

x
⁢
x

=
0

,

(
x
,
t
)

∈

(
0
,
ℓ
)

×

(
0
,
T
]

,

\rho(x)u_{tt}+\mu(x)u_{t}+(r(x)u_{xx})_{xx}+(\kappa(x)u_{xxt})_{xx}=0,\quad(x,%
t)\in(0,\ell)\times(0,T],

subject to the boundary conditions

u
⁢

(
0
,
t
)

=
0

,

u
x

⁢

(
0
,
t
)

=
0

,

[

r
⁢

(
x
)

⁢

u

x
⁢
x

+

κ
⁢

(
x
)

⁢

u

x
⁢
x
⁢
t

]

x
=
ℓ

=
0

,

-

[

(

r
⁢

(
x
)

⁢

u

x
⁢
x

+

κ
⁢

(
x
)

⁢

u

x
⁢
x
⁢
t

)

x

]

x
=
ℓ

=

g
⁢

(
t
)

,

u(0,t)=0,\quad u_{x}(0,t)=0,\quad[r(x)u_{xx}+\kappa(x)u_{xxt}]_{x=\ell}=0,%
\quad-[(r(x)u_{xx}+\kappa(x)u_{xxt})_{x}]_{x=\ell}=g(t),

for

t
∈

[
0
,
T
]

{t\in[0,T]}

,
from the measured deflection

ν
⁢

(
t
)

:=

u
⁢

(
ℓ
,
t
)

{\nu(t):=u(\ell,t)}

,

t
∈

[
0
,
T
]

{t\in[0,T]}

, and from the bending moment

ω
⁢

(
t
)

:=

-

(

r
⁢

(
0
)

⁢

u

x
⁢
x

⁢

(
0
,
t
)

+

κ
⁢

(
0
)

⁢

u

x
⁢
x
⁢
t

⁢

(
0
,
t
)

)

,

t
∈

[
0
,
T
]

,

\omega(t):=-(r(0)u_{xx}(0,t)+\kappa(0)u_{xxt}(0,t)),\quad t\in[0,T],

where the terms

(

κ
⁢

(
x
)

⁢

u

x
⁢
x
⁢
t

)

x
⁢
x

{(\kappa(x)u_{xxt})_{xx}}

and

μ
⁢

(
x
)

⁢

u
t

{\mu(x)u_{t}}

account for the Kelvin–Voigt damping and external damping, respectively.
The main purpose of this study is to analyze the Kelvin–Voigt damping effect on determining the unknown transverse shear force (boundary input) through the given boundary measurements. The inverse problems are transformed into minimization problems for Tikhonov functionals, and it is shown that the regularized functionals admit unique solutions for the inverse problems. By suitable regularity on the admissible class of shear force

g
⁢

(
t
)

{g(t)}

, we prove that these functionals are Fréchet differentiable, and the derivatives are expressed through the solutions of corresponding adjoint problems posed with measured data as boundary data associated with the direct problem. The solvability of these adjoint problems is obtained under the minimal regularity of the boundary data

g
⁢

(
t
)

{g(t)}

, which turns out to be the regularizing effect of the Kelvin–Voigt damping in the direct problem. Furthermore, using the Fréchet derivative of the more regularized Tikhonov functionals, we obtain remarkable Lipschitz stability estimates for the transverse shear force in terms of the given measurement by a feasible condition only on the Kelvin–Voigt damping coefficient.
Correlation between descriptive and group type traits in the system of cow’s linear classification of Ukrainian Brown dairy breed
Authors: Khmelnychyiі Leontiі , Khmelnychyiі Serhii , Samokhina Yevgeniya
Published: February 2023

The aim of this study was to evaluate the phenotypic relationships between descriptive and group linear-type traits and the final score of first-born cows of the Ukrainian Brown dairy breed. The data from the linear estimation were collected on the population of 707 cows in six herds in the Sumy region of Ukraine from 2000 to 2018. It was found that the level of correlations between descriptive and group traits of the conformation, which characterize the dairy strength, frame, feet/legs, and udder, differed in significant variability by direction, strength, and reliability. The level of positive phenotypic correlations of descriptive traits with all group traits of the conformation type and the final score was height (0.19–0.34 and 0.34), chest width (0.06–0.29 and 0.17), body depth (0.28–0.53 and 0.48), angularity (0.35–0.77 and 0.62), rump width (0.29–0.36 and 0.46), rear legs posture (0.33–0.37 and 0.48), front udder attachment (0.23–0.39 and 0.41), height of rear udder attachment (0.17–0.27 and 0.29), and central ligament (r = 0.16–0.39 and 0.36). The body condition score was related to group traits but in a negative value, with correlation coefficients ranging from −0.07 (legs) to −0.47 (dairy strength). The level of correlation between descriptive traits and the final score indicated that the selection based on the results of good development of these traits will contribute to the overall progress of cows in the direction of the desired dairy type.
Lp
-solution for BSDEs driven by a Lévy process
Authors: El Jamali Mohamed
Published: February 2023

This paper deals with the problem of existence and uniqueness of

𝕃
p

{\mathbb{L}^{p}}

-solutions for a backward stochastic differential equation in a filtration that supports Lévy processes with

p
∈

(
1
,
2
)

{p\in(1,2)}

. However, we will focus on when the data satisfy the appropriate integrability conditions and when the coefficient is Lipschitz.
How Czech Democracy Defies the Illiberal Trend
Authors: Buben Radek , Kouba Karel
Published: February 2023

Democratic backsliding in Hungary and Poland has raised questions as to whether Czech politics would follow a similar path. Focusing on transformations in the country’s political system over the past decade, this article argues that Czech democracy has proved resilient and defied the Central European illiberal trend. The starkly divergent outcomes are attributable to differences that set the Czech political tradition apart from those of Poland and Hungary. The liberal, secular, and pluralist tendencies present in the Czech democratic myth have made it more difficult to form an ideologically based movement built around a national-religious conservative narrative challenging liberal democratic values.
First-principles studies of the structural, elastic, vibrational, and thermodynamic properties of nonlinear chalcogenide LiGaTe2 under pressure
Authors:   LDDI–Laboratory, Faculty of Science and Technology, University Ahmed Draia of Adrar, 01000, Algeria, Guenfoud M. , Hamouda M. ,   LDDI–Laboratory, Faculty of Science and Technology, University Ahmed Draia of Adrar, 01000, Algeria, Arbaoui I. ,   LESEM Laboratory, Oran1 University, Ahmed Ben Bella, 31000, Algeria
Published: February 2023

First-principles calculations for the structural, elastic, thermal and vibrational properties of LiGaTe2 under pressure up to 5GPa have been systematically investigated within the framework of the density functional theory. The lattices parameters found a, c and the bulk modulus B under zero pressure and zero temperature are close with the experimental data and the theoretical results. The analysis of the mechanical constants and the frequencies of the phonons found, confirms that the compound LiGaTe2 is dynamically and mechanically stable up to 5GPa. The effect of pressure on elastic constants Cij, bulk modulus B, Young's modulus E, Poisson ratio ν, shear modulus G, and compressibility k of LiGaTe2 are also successfully obtained and discussed. In addition, the thermal properties of LiGaTe2, such the heat capacity CV and Cp, the grüneisen parameter γ and the thermal expansion coefficient α are predicted by the quasi-harmonic approximation (QHA).
GSH capped Cu-Zn-In-S quantum dots: one-pot aqueous synthesis and cell labeling applications
Authors:   College of Medical Technology, Qiqihar Medical University, Qiqihar, Heilongjiang 161006, China, Zhang L. , Wan Y. ,   College of Medical Technology, Qiqihar Medical University, Qiqihar, Heilongjiang 161006, China, Wu Y. ,   College of Medical Technology, Qiqihar Medical University, Qiqihar, Heilongjiang 161006, China, Wang J. ,   College of Medical Technology, Qiqihar Medical University, Qiqihar, Heilongjiang 161006, China, Xu D. ,   College of Medical Technology, Qiqihar Medical University, Qiqihar, Heilongjiang 161006, China, Duan W. ,   College of Medical Technology, Qiqihar Medical University, Qiqihar, Heilongjiang 161006, China, Chen D. ,   College of Medical Technology, Qiqihar Medical University, Qiqihar, Heilongjiang 161006, China, Liu D. ,   bCommunication and Electronic Engineering Institute, Qiqihar University, Qiqihar, Heilongjiang 161006, China
Published: February 2023

We report a one-pot method to directly synthesize highly luminescent Cu-In-Zn-S quantum dots(CIZS QDs) in aqueous media by using bio-compatible glutathione (GSH) as capping ligand and stabilizer. The influences of various experimental variables, including reaction time, pH value, and precursor ratio, have been systematically investigated. As a result, the stable ternary CIZS QDs with good photoluminescence emission properties and narrow size distribution can be obtained. In addition, the obtained GSH capped CIZS QDs exhibited excellent optical performance and water stability. It is a promising fluorescent probe for biological labels due to the absence of toxic heavy metal ions.
Radiation protection assessment of gamma photons in 64TeO2–10WO3–10Nb2O5– 15KF–1La2O3 glasses doped with Tm2O3 using photon-shielding and dosimetry software
Authors:   Medical and Clinical Affairs Department, King Faisal Medical City, Abha 62523, Saudi Arabia, Alqahtani A. M. , Alqahtani M. S. ,   Department of Radiological Sciences, College of Applied Medical Sciences, King Khalid University, Abha 61421, Saudi Arabia,   BioImaging Unit, Space Research Centre, Department of Physics and Astronomy, University of Leicester, Leicester LE1 7RH, UK, Hussein K. I. ,   Department of Radiological Sciences, College of Applied Medical Sciences, King Khalid University, Abha 61421, Saudi Arabia,   Department of Medical Physics and Instrumentation, National Cancer Institute, University of Gezira, Wad Medani 20, Sudan, Alkulib A. J. ,   Department of Radiological Sciences, College of Applied Medical Sciences, King Khalid University, Abha 61421, Saudi Arabia, Alqahtani F.F. ,   Department of Radiological Sciences, College of Applied Medical Sciences, Najran University, Najran 1988, Saudi Arabia, Yousef E. ,   Research Center for Advanced Materials Science (RCAMS), King Khalid University, Abha 61421, Saudi Arabia,   Physics Department, Faculty of Science, King Khalid University, Abha 61421, Saudi Arabia,   Physics Department, Faculty of Science, Al Azhar University, Assiut branch, Egypt
Published: February 2023

Radiation-shielding applications are necessary to protect against deleterious effects of radiation. This study tested thulium oxide (Tm2O3) added to the glass-system composition 64TeO2–10WO3–10Nb2O5–15KF–1La2O3. Adding Tm2O3 increased sample density from 5.22 to 5.40 g/cm3 and measured at photon energy of 15 keV–15 MeV. Multiple radiationshielding parameters were evaluated and assessed using photon-shielding and dosimetry software, including linear and mass attenuation coefficients, half-value layers, mean free paths, atomic and electronic cross sections, effective atomic numbers, effective electron density, and exposure buildup factors. Half-value layer and mean free-path values were compared with those of well-known radiation-shielding materials, ie, conventional concrete and commercial glasses. Atomic and electronic cross-section values effectively increased with the addition of thulium oxide to the glass systems. While the highest linear and attenuation coefficients were 242–281 cm2 /g at 15 keV, the denser glass recorded the highest mass attenuation coefficients value of 52.17 cm2 /g across all samples. The highest effective atomic number and effective electron density were recorded for the denser glass, because it had the highest thulium oxide fraction and was more burdened by interaction with photon energy. Half-value layers and mean free paths showed similar behavior, and high-density materials achieved low values. At high energy, exposure buildup-factor values increased, while at low energy, values decreased.
Hydrocarbons detection using surface plasmon resonance with As2S3 thin film waveguide
Authors:   National Institute R&D of Optoelectronics, INOE 2000, 409 Atomistilor str., PO BOX MG. 5, 77125 Magurele, Ilfov, Romania, Baschir L. , Miclos S. ,   National Institute R&D of Optoelectronics, INOE 2000, 409 Atomistilor str., PO BOX MG. 5, 77125 Magurele, Ilfov, Romania, Savastru D. ,   National Institute R&D of Optoelectronics, INOE 2000, 409 Atomistilor str., PO BOX MG. 5, 77125 Magurele, Ilfov, Romania, Simandan I. D. ,   National Institute of Materials Physics, Atomistilor 405A, Magurele 077125, Romania, Popescu A. A. ,   National Institute R&D of Optoelectronics, INOE 2000, 409 Atomistilor str., PO BOX MG. 5, 77125 Magurele, Ilfov, Romania
Published: February 2023

Surface plasmon resonance containing amorphous As2S3 film is proposed as a chemical sensor to highlight several liquid hydrocarbons. Method is label-free and is based on detection of small changes in the refractive index. As2S3 operates as plasmonic waveguide which confines the probing beam to the interface with liquid hydrocarbons. The method can easily distinguish hydrocarbons with very close refractive indices. The film thicknesses were optimized to obtain the best sensitivity and resolving power. Minimum reflectance of SPR less than 1 % was found for optimal calculated film thicknesses, the sensitivity to the refractive index changes being 2·10-5 .
MULTIFUNCTIONAL NANOPARTICLE PLATFORMS FOR BIOMEDICAL APPLICATIONS: A REVIEW
Authors:   Nuclear Engineering Department, Faculty of Engineering, King Abdulaziz University, Po Box 80204, Jeddah, 21589, Saudi Arabia, ABOLABAN F. , DJOUIDER F. ,   Nuclear Engineering Department, Faculty of Engineering, King Abdulaziz University, Po Box 80204, Jeddah, 21589, Saudi Arabia
Published: February 2023

Many scientific and technological areas have benefited, in the last few decades, considerably from the introduction of nanomaterials especially the biomedical field. Despite the use of a myriad of drugs to diagnose and treat diseases, the dilemma is how to selectively target diseased cells while lessening collateral harmfulness to surrounding healthy tissues. Novel advances in theragnostics showed that nanoparticles (NPs), owing to their exceptional physicochemical properties, are an exceptional integrated platform for this purpose. This review paper first depicts nanoparticles in their general structural aspects and second, in their application in medicine (bioconjugation with drugs, cellular internalization, drug delivery and phagocytosis).
EFFECTS OF ANNEALING ON THE PHYSICAL PROPERTIES OF ITO THIN FILMS GROWN BY RADIO FREQUENCY MAGNETRON SPUTTERING
Authors:   University of Bucharest, Faculty of Physics, 405 Atomistilor, Magurele, 077125, Ilfov, Romania, RADU A. , LOCOVEI C. ,   University of Bucharest, Faculty of Physics, 405 Atomistilor, Magurele, 077125, Ilfov, Romania, ANTOHE V. A. ,   University of Bucharest, Faculty of Physics, 405 Atomistilor, Magurele, 077125, Ilfov, Romania, SOCOL M. ,   National Institute of Materials Physics, 405A Atomistilor, Magurele, 077125, Ilfov, Romania, COMAN D. ,   University of Bucharest, Faculty of Physics, 405 Atomistilor, Magurele, 077125, Ilfov, Romania, MANICA M. ,   University of Bucharest, Faculty of Physics, 405 Atomistilor, Magurele, 077125, Ilfov, Romania, DUMITRU A. ,   University of Bucharest, Faculty of Physics, 405 Atomistilor, Magurele, 077125, Ilfov, Romania, DAN L. ,   University of Bucharest, Faculty of Physics, 405 Atomistilor, Magurele, 077125, Ilfov, Romania, RADU C. ,   University of Bucharest, Faculty of Physics, 405 Atomistilor, Magurele, 077125, Ilfov, Romania, RADUTA A. M. ,   University of Bucharest, Faculty of Physics, 405 Atomistilor, Magurele, 077125, Ilfov, Romania, ION L. ,   University of Bucharest, Faculty of Physics, 405 Atomistilor, Magurele, 077125, Ilfov, Romania, IFTIMIE S. ,   University of Bucharest, Faculty of Physics, 405 Atomistilor, Magurele, 077125, Ilfov, Romania, ANTOHE S. ,   University of Bucharest, Faculty of Physics, 405 Atomistilor, Magurele, 077125, Ilfov, Romania
Published: February 2023

Indium-doped tin oxide (ITO) thin films were fabricated by radio frequency magnetron sputtering and were subjected to in-situ and ex-situ annealing, at 200°C, 300°C and 400°C, respectively. The in-situ thermal treatment consisted to intentionally heating the samples’ substrates, while the ex-situ annealing was performed using an oven, under ambient atmosphere. For the ITO samples subjected to ex-situ annealing, the density of oxygen vacancies increased leading to the decrease of the electrical resistivity. No significant changes were noticed in terms of transmission spectroscopy after the thermal treatment; while by evaluating the Skewness parameter was determined that the annealing improves the planarity of samples’ surface.
EFFECT OF BORIC ACID CONCENTRATIONS ON THE CHARACTERIZATION OF THE In2O3 THIN FILMS GROWTH BY SPRAYING PYROLYSIS METHOD
Authors:   Selcuk University Karapınar Aydoğanlar Vocational School, 42400- Konya/TURKEY, TEMİZ M. , YILDIRIM R. G. ,   Eng. Fac. Department of Engineering Physics, Gaziantep University, 27310- Gaziantep/TURKEY, BEDİR M. B. ,   Eng. Fac. Department of Engineering Physics, Gaziantep University, 27310- Gaziantep/TURKEY, ÖZTAŞ M. ,   Eng. Fac. Department of Engineering Physics, Gaziantep University, 27310- Gaziantep/TURKEY
Published: February 2023

Indium oxide thin films with undoped and boron doped were produced by spray pyrolysis method at a substrate temperature of 380 °C on the glass substrate using boric acid (H3BO3) as the dopant source. The effects of doping concentration on the features of undoped and boron doped In2O3 thin films have been investigated. The XRD analyses indicate that all thin films are polycrystalline with cubic structure, which is the dominant peaks of the (222), (400), (440) and (622) reflection planes with lattice parameter, approximately 9-10 Å. As the boron enters the structure, a decrease in band gap energy occurs. This decrease continues up to 0.03 M of boron additives and tends to increase again above this value. As the boron concentration increases up to 0.03 M, the resistance value decreases and the carrier concentration and Hall mobility values increase, which caused by the scattering of carriers that are severely weakened due to increased crystal quality.
INVESTIGATIONS ON HYDROTHERMAL SYNTHESIS PARAMETERS IN PREPARATION OF ZEOLITE W
Authors:   College of Chemistry and Chemical Engineering, Xuchang University, Xuchang, 461000, China, ZHANG X. , LIU Q. ,   College of Chemistry and Chemical Engineering, Xuchang University, Xuchang, 461000, China, YANG S. ,   College of Chemistry and Chemical Engineering, Xuchang University, Xuchang, 461000, China
Published: February 2023

Zeolite W crystals were synthesized via hydrothermal process, the influence of crystallization time, aging time and temperature, the molar ratios Al2O3/SiO2 and K2O/SiO2 on the crystalline final products were studied. The results revealed that well-developed twin-ball shaped morphology zeolite W crystals were obtained after 6 h of crystallization, the longer crystallization time would not result in substantial changes in crystal morphology and size of end products. However, the crystals transferred from twin-ball to bouquet-like in shape with increasing aging time, while the high aging temperature resulted in zeolite F developed. Also, the Al2O3/SiO2 and K2O/SiO2 molar ratios of the hydrogel had major influences on synthesis of pure form zeolite W. Well-crystallized pure phase zeolite W products were obtained with Al2O3/SiO2=0.20, which were composed of many square pillars crystals, with average width in the range of 0.2–0.5 μm and length approximately 10 μm. Mild alkalinity circumstance was in favor of zeolite W crystallization, when the K2O/SiO2 molar ratio was increased to 9.42, the product obtained was pure phase of zeolite LTJ.
THICKNESS INFLUENCE ON THE PYROELECTRIC SIGNAL OF DOPPED PZT CERAMIC PELLETS
Authors:   National Institute of Materials Physics, Atomistilor 405A, 077125 Magurele, Ilfov Romania, STANCU V. , BOTEA M. ,   National Institute of Materials Physics, Atomistilor 405A, 077125 Magurele, Ilfov Romania, AMARANDE L. ,   National Institute of Materials Physics, Atomistilor 405A, 077125 Magurele, Ilfov Romania, PINTILIE L. ,   National Institute of Materials Physics, Atomistilor 405A, 077125 Magurele, Ilfov Romania
Published: February 2023

Pb0.98Bi0.02Zr0.5Fe0.1Nb0.09Ti0.31O3 (PBiZFNT) powder obtained by a solid state reaction technique was uniaxial pressed and sintered at 1200°C in order to fabricate dense thin disk ceramics with different thickness (200µ up to 600µm). The pyroelectric response was influenced by the thickness of the ceramics. The thin ceramic disks of 250 µm thickness show better pyroelectric signal (≈35 mV) which recommend them for potential use in laser energy meters.
SYNTHESIS OF GRAPHENE/Mn0.2Cd0.8S HIERARCHICAL NANOSPHERES FOR PHOTOCATALYTIC DEGRADATION OF ORGANIC POLLUTANTS
Authors:   College of Mechanical Engineering, Hunan University of Arts and Science, Changde 415000, People’s Republic of China, ZENG B. , WANG R. ,   Hunan Collaborative innovation Center for construction and development of Dongting Lake Ecological Economic Zone, Changde 415000, People’s Republic of China
Published: February 2023

The hierarchically structured hybrids of graphene and Mn0.2Cd0.8S solid-solution, resulting in G/Mn0.2Cd0.8S HN, are successfully synthesized by using microwave method with the assistance of L-Histidine. Moreover, X-ray diffraction (XRD), UV-vis absorption spectroscopy, scanning electron microscopy (SEM) and transmission electron microscopy (TEM) are employed to analyze the structural and optical properties. Furthermore, the decoloration of methyl orange (MO) under visible light irradiation indicates that the G/Mn0.2Cd0.8S HN is a promising photocatalyst for the degradation of organic pollutants. Herein, a possible photocatalytic mechanism of G/Mn0.2Cd0.8S is proposed, showing the synergistic influence of hierarchical nanospheres morphology, optimal bandgap and conductive graphene scaffold on photocatalytic activity. Overall, the photodegradation performance is improved due to the effective separation of electron/hole pairs and efficient transportation of photogenerated electrons from Mn0.2Cd0.8S to graphene. The current work demonstrates an environment-friendly route to fabricate multi-component chalcogenides for high-performance photocatalytic applications.
PREPARATION, ELECTROCHEMISTRY PROPERTIES OF LiNi0. 5－xFe0.0485Mn1. 5－yO4 BY SPRAY-DRY METHOD WITH DIFFERENT Mn/Ni RATIOS
Authors:   Central Academe, Shanghai Electric Group. Co., Ltd, Shanghai, [200433], China, ZHOU L. , LI W. ,   Central Academe, Shanghai Electric Group. Co., Ltd, Shanghai, [200433], China, WAN L. ,   Central Academe, Shanghai Electric Group. Co., Ltd, Shanghai, [200433], China
Published: February 2023

LiNi0.5Mn1.5O4 is considered to be one of the most promising cathode material for next generation high-energy density secondary lithium batteries because of its high theoretical specific capacity of 146.7 mA h g−1 and high theoretical specific energy of 650 W h kg−1 . In this work, LiNi0.5－xFe0.0485Mn1.5－yO4 with different Mn/Ni ratios were prepared via spray-dry process by controlling reaction conditions. The results show that LiNi0.5－ xFe0.0485Mn1.5－yO4 has good crystallinity, good conductivity and less impurities with excellent electrochemical properties. The electrochemical tests show that the LiNi0.485Fe0.0485Mn1.475O4 sample delivers a high initial discharge capacity of 128 mA h g-1 and a good cycling stability (reversible discharging capacity of 124 mA h g-1 with a capacity retention of 95% in 200 cycles and approximately 124 mA h g-1 in 300 cycles operated at 1 C rate).
PREPARATION OF MIXED In2O3 – CdO THIN FILMS BY CSP TECHNIQUE FOR LIGHT SENSING
Authors:   Department of Physics, College of Science, University of Baghdad , Baghdad, Iraq, MOHAMMED A. A. , ALYAS M. K. ,   Ministry of Education, Nineveh Education, Nineveh, Iraq, IBRAHIM I. M. ,   Department of Physics, College of Science, University of Baghdad , Baghdad, Iraq, ALI I. M. ,   Department of Physics, College of Science, University of Baghdad , Baghdad, Iraq
Published: February 2023

In this work, chemical spray pyrolysis deposition (CSP) technique was used to prepare a mixed In2O3-CdO thin films with different CdO content (10, 30 and 50)%volume ratio on glass substrates at 150 ᵒC substrate temperature. The surface morphology and structural properties were measured to find the optimum conditions to improve thin films properties for using as photo detector. Current –Time, the sensitivity and response speed vary for each mixture. Samples with 10% vol. CdO content has square pulse response with average rise time nearly 1s and fall time 1s.
FLUOROMETRIC DETERMINATION OF HYDROGEN PEROXIDE USING Fe3O4 MAGNETIC NANOPARTICLES AS A MIMETIC ENZYME
Authors:   School of Chemistry and Chemical Engineering, Guangxi University, Nanning, Guangxi 530004, China, FENG X. , YANG J. ,   Medical College, Guangxi University of Science and Technology, Liuzhou, Guangxi, 545006, China, WU S. ,   Medical College, Guangxi University of Science and Technology, Liuzhou, Guangxi, 545006, China, LIAO D. ,   School of Chemistry and Chemical Engineering, Guangxi University, Nanning, Guangxi 530004, China
Published: February 2023

Hydrogen peroxide（H2O2）is used as a chemical in many food industries and excessive residual H2O2 in the food will cause harm to people's health. To establish a simple, low-cost and accurate analytical methods to detect H2O2 by using metal oxide nanoparticle as mimetic enzyme. In this paper, we utilized the instinct peroxidase-like property of Fe3O4 magnetic nanoparticles (Fe3O4MNPs) to establish a fluorescence assays of H2O2 and benzoic acid (BA) as indicator. Fe3O4MNPs were prepared by co-precipitation and characterized using TEM, magnetization and N2-BET surface area measurement. The fluorescence of system (with excitation/emission peaking at 294/411 nm) was enhanced on increasing the concentration of H2O2 due to form hydroxybenzoic acid. Under optimized conditions, the system gave a ratiometric fluorometric response in the 0.5 to 12.5 μM H2O2 with a 0.122 μM limit of detection. The Ea and Km for the reaction of H2O2 with the Fe3O4MNPs were respectively calculated to be 44.65 kJ/mol and 234.30 mM. The system is highly sensitive and selective toward H2O2 which the relative standard deviation (RSD) of samples was 4.86% (n=6). The proposed method provides a quick, easy and cheap way and was applied to the determination of H2O2 in disposable chopsticks with satisfactory results. The average hydrogen peroxide content in disposable chopsticks was 2.321±0.32 mg/kg. The method for H2O2 determination described here would be of great value in food and agricultural industry.
EFFECT OF ALUMINA TRIHYDRATE WITH ACRYLONITRILE BUTADIENE STYRENE / GRAPHENE NANOPLATELETS AND BASALT FABRIC ON PROPERTY ENHANCEMENT
Authors: METRO M. M. , SELVARAJ M. ,   Sri Sivasubramaniya Nadar College of Engineering, Department of Mechanical Engineering, Kalavakkam, 603 110, Chennai, India
Published: February 2023

During the last several decades, polymeric composites have attracted much attention from researchers and industrialists due to their excellent mechanical and thermal properties. Currently, these materials are gradually replacing metallic parts in bearings, home appliances, and electrical devices. This study investigated the physical and mechanical responses of thermoplastic composite laminates fabricated from acrylonitrile-butadienestyrene polymer, graphene nanoplatelets, alumina trihydrate powder, and single-ply woven basalt fabric reinforced by a hot-pressing method. The main properties of these laminates were evaluated by applying appropriate testing standards. The obtained results indicated that the prepared thermoplastic composites possessed enhanced mechanical properties as compared with those of the polymer matrix without fillers.
MANAJEMEN DAN PENGURANGAN RISIKO BENCANA MELALUI PENGEMBANGAN DESA TANGGUH BENCANA (DESTANA)
Authors: Nugroho Efa , Indarjo Sofwan , Nisa Alfiana Ainun , Isniyati Heni , Hermawan Dwi Yunanto , Widyaningrum Heny , Wasono Edy , Laily Linuria Asra , Utami Annisa Novanda Maharani , Suci Cahyani Wulan , Yuswantoro Rico Novian
Published: February 2023

Bencana alam merupakan acaman besar bagi Indonesia. Selama  tahun 2020,  dilaporkan terjadi bencana sejumlah 2.939 kejadian di Indonesia. Kabupaten Magelang merupakan salah satu wilayah di provinsi Jawa Tengah yang memiliki tingkat risiko bencana yang tinggi. Kabupaten Magelang juga berada pada sesar tektonik yang berpotensi terjadi gempa bumi. Selain itu, aspek iklim juga menjadi ancaman bencana, pasalnya curah hujan yang dibarengi oleh aktivitas vulkanik maupun tektonik dapat memicu bencana tanah longsor dan banjir. Pengembangan Desa Tangguh Bencana (DESTANA) dapat dijadikan sebagai upaya pengurangan risiko bencana dengan berbasis pemberdayaan masyarakat. Kegiatan pengembangan DESTANA ini bertujuan untuk: 1). Menggambarkan risiko bencana di Kabupaten Magelang, 2). Menggambarkan kondisi masyarakat Kabupaten Magelang dalam Kesiapsiagaan Penanggulangan Bencana, 3). Mengembangkan model desa tangguh bencana dengan pendekatan Participatory Action Research di Kabupaten Magelang. Dalam implementasinya, program ini bekerjasama dengan Perkumpulan Keluarga Berencana Indonesia (PKBI) dan Badan Penanggulangan Bencana Daerah (BPBD) Kabupaten Magelang. Temuan penelitian menginformasikan pengembangan model DESTANA dalam upaya manajemen dan pengurangan risiko bencana di Kabupaten Magelang. Konsisten dengan pendekatan participatory action research, mereka yang paling berisiko terdampak bencana akan dilibatkan dalam semua fase penelitian termasuk desain awal, pengembangan penelitian alat dan proses, pengumpulan dan analisis data, desain dan implementasi intervensi, dan penyusunan program.
Antonio Arroyo Almaraz (dir.), José Manuel Mora-Fandos & Manuel A. Broullón-Lozano (eds): "Galdós". "Nuevas Visiones". Madrid: Fragua, 2021. ISBN 978-84-7074-907-0. 189 pp.
Authors: Rodríguez González Luis
Published: February 2023

Reseña del libro Galdós. Nuevas visiones, resultado de la celebración del centenario del Benito Pérez Galdós (1920-2020). Coordinador: Antonio Arroyo Almaraz
First generation of residents in the era of Covid-19. Giving honor to whom honor is due
Authors: M. Whizar-Lugo Victor , Iñiguez- López Karen
Published: February 2023

Since its first report in December 2019, coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become the most recent pandemic rapidly affecting all countries of the planet, leaving until today a balance of 118 754 336 infected persons and 2 634 370 fatalities in the world. As the COVID-19 pandemic progresses, it has modified our way of life, the economy has been severely damaged, and health systems have been insufficient throughout the planet. The COVID-19 pandemic had in a short time rapid and unavoidable effects on the training and work plans of all new healthcare personnel, especially residents, interns, and nurses, as well as undergraduate students from medicine and nursing. The first generation of specialists and subspecialists trained under these changes have just graduated. The last year of their medical training was damaged due to the time they had to spend managing COVID-19 patients. Many of these young doctors lost their lives in the line of fire. The training of the fellows who survived should be complemented in their first years of their practice as specialists, but their knowledge and skills acquired during their residency will benefit global health by having doctors properly trained in the fight against COVID-19.
Successful treatment with transesophageal pacemaker for medically refractory bradycardia during endovascular thoracoabdominal aortic aneurysm surgery: 2 case reports
Authors: Larsen MD Elizabeth R , Luk MD MS K H Kevin
Published: February 2023

We present two cases of external pacing using esophageal atrial pacing for the treatment of medically refractory bradycardia during endovascular treatment of thoracoabdominal aortic aneurysms (TAAA) under general anesthesia. TAAA are life-threatening medical emergencies. Prompt management is required to prevent rupture or further dissection. Management focuses on impulse and blood pressure control followed by endovascular repair. Beta-blockers and antihypertensives are considered first line agents. General anesthetics can potentiate the effect of these medications intraoperatively. In our patients, favorable outcome was achieved using transesophageal pacing. Currently, there is limited literature supporting the use of transesophageal pacing in the perioperative setting.
Direct Admission to Hospital for Children in the United States
Authors: Leyenaar JoAnna K. , Hill Vanessa , Lam Vinh , Stern Rebecca , Vaughan Kristin Williams ,   COMMITTEE ON HOSPITAL CARE, Rauch Daniel A. , House Samantha , Hsu Benson , Mauro-Small Melissa , Ortiz-Mato Nerian , Vinocur Charles , Webb Nicole , Hill Vanessa , Ernst Kimberly , Lam Vinh , Leonard Michael S. , Castleberry Karen , Hanson Nancy , Gigli Kristin Hittle , Romito Barbara , Alexander S. Niccole
Published: February 2023

One in four unscheduled hospital admissions for children and adolescents in the United States occurs via direct admission, defined as hospital admission without first receiving care in the hospital’s emergency department. The purpose of this policy statement is to present recommendations to optimize the quality and safety of this hospital admission approach for children. Recommendations included in this policy statement provide guidance related to: (i) direct admission written guidelines, (ii) clear systems of communication between members of the health care team and with families of children requiring admission, (iii) triage systems to identify patient acuity and disease severity, (iv) identification of hospital resources needed to support direct admission systems of care, (v) consideration of patient populations that may be at increased risk of adverse outcomes during the hospital admission process, (vi) addressing the relevance of local factors and resources, and (vii) ongoing evaluation of direct admission processes and outcomes. The recommendations included in this policy statement are intended to support the implementation of safe direct admission processes and to foster awareness of outcomes associated with this common portal of hospital admission.