bluuebunny/crossref_metadata_2025 huggingface dataset:
Las Competencias Laborales en el Sector Diseño, Confección y Moda de Colombia: Identificación de Retos y Oportunidades a Partir de un Estudio de Caso
Authors: Velásquez Restrepo Sandra Milena , Gaviria Londoño Fabio Andrés , Giraldo Vásquez Diego Hernán
Published: July 2024

Se presenta un estudio de caso con funcionarios de empresas del sector diseño, confección y moda de Colombia, identificando si su nivel de experticia en veintiséis funciones laborales presenta correlación con su nivel de formación, tiempo de experiencia laboral y edad. La experiencia laboral mostró ser un factor más incidente sobre la apropiación de las competencias laborales que el nivel de formación alcanzado. Se identificó que las brechas en materia de competencias laborales que deben abordarse se relacionan con el uso de tecnologías para mercadeo y producción, el desarrollo de materiales con tecnologías de punta y el desarrollo sostenible.
Phthalates Adsorption on Nanostructures for Environmental Remediation: an ab initio Study
Authors: Tonel Mariana , Schemmer Jaine , Vendrame Laura , Zanella Ivana , Fagan Solange
Published: July 2024

Phthalates are organic molecules found in various everyday materials, such as plastics, but they do not bond chemically to the product. Consequently, they are released and contaminate the environment. In humans, ingesting phthalates can stimulate a functionality similar to estrogen hormones, acting as endocrine disruptors, thus requiring selective adsorption. This paper demonstrates the use of cyclodextrins (CDs), which are useful due to their capacity for selective adsorption by the inclusion of organic molecules in their internal cavities to remove pollutants from water. Graphene (Gr) is also evaluated due to its interesting electronic properties and a large surface, making this nanomaterial ideal for molecule adsorption. Through ab initio simulations, three phthalate molecules, benzyl butyl phthalate (BBP), dicyclohexyl-phthalate (DCHP), and dipropyl phthalate (DPP) interacting with β-CD and Gr, were evaluated. The results indicate that a weak interaction occurs, through physical adsorption. β-CD interacting with phthalates tends to form a host-guest complex. In the case of Gr, weak adsorption is favored by π-π interactions and H-bonds. Therefore, this study shows that these nanosystems are promising for removing phthalate molecules from wastewater.
Apakah Kepemimpinan Memiliki Peran Moderasi dalam Kualitas Pengawasan pada Auditor Internal Pemerintah?
Authors: Arif Rizal Nur , Firmansyah Amrie
Published: July 2024

This research aims to analyze the influence of competence, independence and integrity on the quality of supervision carried out by auditors at the BPKP Representative Office of Banten Province. This research used 35 Functional Auditor Officials (PFA) at the BPKP Representative Office of Banten Province as respondents. This quantitative research uses SEMPLS with the SmartPLS application as a supporting application in data processing. This research shows that auditor competence has a positive effect on the quality of supervision, while auditor independence and integrity have no effect on the quality of supervision. The research also concludes that leadership does not strengthen the positive influence of the partial relationship between auditor competence, independence and integrity on supervisory quality. It is hoped that the results of this research can provide input for the Banten Province BPKP Representative so that they can implement policies that focus on developing PFA competencies to improve the quality of supervision. This research contributes to the literature on public sector internal auditing, which is still rare in previous research, especially when using Indonesian data. This research also places leadership moderating variables in the relationship between independent and dependent variables, which have rarely been used in previous research.
Faktor yang Mempengaruhi Keputusan Transfer Pricing pada Perusahaan Sektor Consumer Non-Cyclicals
Authors: Sari Natasya Permata , Veni Veni
Published: July 2024

The study aimed to determine the impact of Tax Minimization, Company Size, Debt Covenant, and Profitability on the Transfer Pricing decision in non-cyclical companies. The theoretical framework supporting this study is the agency theory. The study used a quantitative causal comparative approach with a population and sample of non-cyclical companies listed on the Indonesia Stock Exchange (BEI) from 2018 to 2022. The sample was obtained based on predefined criteria. The analysis in this study included descriptive statistics, classical assumption tests, and linear regression analysis, which was processed using IBM SPSS version 25. Based on the test results, it was found that: (1) Tax Minimization had a significant negative impact on transfer pricing; (2) Company Size had not a significant positive impact on transfer pricing; (3) Debt Covenant had a significant negative impact on transfer pricing; (4) Profitability had not a significant negative impact on transfer pricing.
Kant no Século XXI
Authors: Bresolin Keberson , Moreira Paulsen Carolina
Published: July 2024

O presente artigo busca expor, sucintamente, o direito cosmopolita kantiano como um princípio aplicável à situação dos refugiados no mundo atual. Para isso, primeiro será exposto o conceito de direito cosmopolita na obra À Paz Perpétua (1795), de Kant. Em um segundo momento, será abordada a formação do pensamento cosmopolita kantiano, como uma ideia oposta ao egoísmo, na sua cidade natal de Königsberg. Por fim, apresentaremos uma história de refúgio do mundo atual e a cotejaremos com o princípio de hospitalidade exigido pelo direito cosmopolita kantiano, para demonstrar que o tratamento dado aos refugiados, como regra geral, viola os princípios kantianos propostos na Paz Perpétua. A finalidade deste artigo é demonstrar que o direito cosmopolita, extraído da filosofia kantiana, pode e deve ser pensado como um princípio norteador para o tratamento dos refugiados no mundo atual, e que isso levaria a um tratamento digno e condizente com a humanidade e dignidade dos buscadores de refúgio, os cidadãos do mundo no século XXI.
Pensamento Livre e Obediência
Authors: Borges de Santana Junior Paulo
Published: July 2024

De duas maneiras distintas, Kant articula a liberdade de pensamento com a obediência civil. No texto sobre o Esclarecimento, o uso público da razão seria “a mais inofensiva de todas as liberdades”, colocando-se, juntamente com mote de Frederico II, em paradoxo com a liberdade civil. Passando ao Conflito das Faculdades, cujo prefácio tematiza a obediência à luz de uma carta de censura e de sua resposta, Kant defenderá uma prerrogativa da Faculdade de Filosofia de manter legitimamente um conflito com as faculdades superiores, i.e., com as ciências permeadas pelo poder e pelas ordens de um governante. A partir desses textos, almejamos ressaltar a especificidade de uma liberdade de pensamento tratada não tanto como liberdade civil, mas como uso público da razão. Compreendendo que tal uso não deve ser permitido ou proibido segundo o arbítrio de um governo, pensaremos em que medida a Filosofia enquanto Faculdade contribuiria para garantir essa acepção ativa de público.
FILOSOFIA PRÁTICA DE KANT COMO ANTÍDOTO AO USO DE FAKE NEWS
Authors: Souza Vidal Maia José da Conceição
Published: July 2024

O presente artigo investiga o uso das denominadas fake news, no âmbito da política à luz da filosofia prática kantiana. O histórico das falsas informações, da utilização da mentira na política, a definição de fake news e pós-verdade, a propagação através da manipulação de dados são partes dessa análise e nesse sentido, refletimos como a filosofia prática de Kant, a partir de sua rejeição a mentira pode contribuir como um antídoto com o re-estabelecimento da verdade, da ética na política, nesse cenário do uso exacerbado das falsas notícias. Para tanto, o exercício responsável e racional das liberdades, a valorização da dignidade da pessoa, por sujeitos autônomos em combate a menoridade do pensamento e a heteronomia são fundamentais para o cultivo de outras relações na política, condizentes com a realidade dos fatos e sujeitos éticos comprometidos com a verdade.
Palavras-chave: Kant; filosofia prática; fake News.
Integrating Molecular Biology and Network Pharmacology to Analyze the
Antidepressant Mechanism of Glycyrrhizaglabra
Authors: Liang Liting , Jiang Yongmei , Kuang Linghan , Liu Xingxin , Luo Jingjing , Ling Jiaji , Wu Wenjing
Published: July 2024

Introduction:

Antidepressants have adverse effects and induce drug resistance when
used excessively or frequently. Therefore, adjuvants are needed to reduce the use of antidepressants during treatment. Traditional Chinese medicine (TCM) is an important adjunctive approach to depression with safety, environmental protection, and low toxicity. Glycyrrhizaglabra
(licorice, GG) is a plant commonly used in various herbal remedies.

Method:

We investigated the antidepressant activity of GG, its active constituents, and potential
depression-related targets. We combined animal behavioral and molecular biological assays
with network pharmacology to analyze the antidepressant mechanism of GG. GG extracts reversed lipopolysaccharide (LPS)-induced depression-like behavior in behavioral tests. We selected 56 active compounds and 695 target compounds of licorice from TCMSP. The PPI network screened 80 core targets for enrichment analysis. It shows that GG significantly affected
neurodegeneration pathways, neuroactive ligand-receptor interaction, cAMP signaling pathway,
serotonergic synapse, dopaminergic synapse, and MAPK signaling pathway.

Result:

Mechanistic studies showed that GG reduced IL-1β, IL-6, and TNF-α levels, 5-HTRA1
expression, and GSK3β phosphorylation in mouse hippocampus. It also increased BDNF and
DRD1 expression and CREB and ERK1/2 phosphorylation.

Conclusion:

It shows that GG acted on these proteins to affect multiple pathways that mediate
the pathogenesis of depression.
Promoter Hypermethylation Downregulates MiR-125b-5p and MiR-199b-5p Targeting of ΔNp63, Resulting in PI3K/AKT/mTOR Pathway Activation
and Keratinocyte Differentiation
Authors: Ding Yi , Ma Shi-Qi , Li Min , Chen Long , Feng Shu-Mei
Published: July 2024

Background:

Normal keratinocyte differentiation is important for epidermal wound
healing. ΔNp63 is a major gene regulating epidermal formation and differentiation. We identified
miRNAs targeting ΔNp63 and studied the association between the miRNAs and DNA
methylation in keratinocyte differentiation.

Aims:

This study aimed to explore the mechanisms regulating ΔNp63 expression during
keratinocyte differentiation.

Methods:

Bioinformatics analysis was performed to screen the miRNAs targeting ΔNp63 and uncover
potential pathway mechanisms. The differentiation model of keratinocytes was established
by CaCl2 treatment. Furthermore, the effects of the miRNA transgenic technique on Δ Np63 and
keratinocyte differentiation were studied. In addition, the RNA FISH experiment was conducted to
detect the location of different miRNAs. A double luciferase reporter experiment was carried out to
verify the potential bindings between the miRNAs and ΔNp63. A rescue experiment was also performed
to assess the effects of different miRNAs targeting ΔNp63 on keratinocyte differentiation.
We analyzed the methylation patterns of the promoter regions of miRNAs using keratinocytes
treated with 5-Aza-2’-deoxycytidine. Finally, we designed a methylation rescue experiment to verify
the effects of miRNA promoter methylation on keratinocyte differentiation.

Results:

Bioinformatics analysis showed that the miR-125b-5p and miR-199b-5p binding to the
ΔNp63 3’UTR region decreased during skin development. Moreover, such binding may downregulate
the PI3K/AKT/mTOR pathway. The expression levels of CK10, Inv, TG1, ΔNp63, and
PI3K/AKT/mTOR were all significantly increased during keratinocyte differentiation. Both miR-
125b-5p and miR-199b-5p were localized in the cytoplasm. Luciferase assay results showed that
both miR-125b-5p and miR-199b-5p can bind to the 3’UTR region of ΔNp63. Overexpression of
ΔNp63 can significantly counteract the inhibitory effect of miRNA mimics on keratinocyte differentiation.
Moreover, the promoter regions of both miR-125b-5p and miR-199b-5p had methylation
sites, and the methylation levels in those promoter regions were significantly increased during
keratinocyte differentiation. 5-Aza-2’-Deoxycytidine treatment increased the expression of miR-
125b-5p and miR-199b-5p and inhibited the differentiation of keratinocytes. Finally, miRNA inhibitors
reversed the inhibitory effects of 5-Aza-2’-deoxycytidine on keratinocyte differentiation.

Conclusion:

Promoter hypermethylation in miR-125b-5p and miR-199b-5p seem to promote
keratinocyte differentiation via upregulation of ΔNp63 expression and the activation of the
PI3K/AKT/mTOR pathway. The findings of this study are helpful for future research on skin
development and clinical scar-free healing.
ADAMTS16 Suppression by MicroRNA-25 Leads to Oncogenic Properties in Renal Cell Carcinoma
Authors: Huang Jian , Tang Zhe , Zhong Guangjun , Guo Linjie , Feng Ye
Published: July 2024

Introduction:

Increasing evidence indicates that microRNAs (miRNAs) play a crucial
role in modulating tumor growth. This study is centered on investigating the contribution of
miR-25 to the progression of Renal Cell Carcinoma (RCC).

Methods:

The investigators examined the expression levels of miR-25 and ADAMTS16 in RCC
samples and cell lines. The association between miR-25 and ADAMTS16 was validated via a luciferase
reporter assay. Cell viability, apoptosis, migration, and invasion were evaluated utilizing
CCK-8 and flow cytometry techniques, while the expression levels of ADAMTS16, β-catenin,
GSK-3β, and p-GSK-3β were assessed through western blot analysis.

Results:

The investigation revealed elevated expression levels of miR-25 in RCC tissues. Subsequently,
ADAMTS16 was identified as a target of miR-25. Increased miR-25 levels were associated
with decreased expression of ADAMTS16, resulting in enhanced cell viability and diminished
apoptosis. Conversely, inhibition of miR-25 led to decreased cell viability, proliferation,
and migration. Additionally, the researchers observed that miR-25 triggered the phosphorylation
of GSK-3β and β-catenin while leaving the total GSK-3β level unaffected.

Conclusion:

This study suggests that miR-25 regulates the expression of ADAMTS16 through
the Wnt/β-catenin signaling pathway, providing new insights into the cause and potential treatment
of RCC.
Nanoemulsions in Skin Cancer Therapy: A Promising Frontier
Authors: Basu Biswajit , Dutta Ayon , Ash Dipanjana , Prajapati Bhupendra
Published: July 2024

Skin cancer, a global burden for particularly white people, is classified as various
histopathological types, including malignant melanoma, basal and squamous cell carcinoma, on
the basis of affected different skin layers. Clinical adjuvant therapy (electro-chemotherapy, radio-
and immuno therapy), surgical techniques (Cryosurgery, laser treatment, dermabrasion,
Moh's micrographic surgery), photodynamic treatment and theranostic approaches are confined
only for the treatment of serious health issues. Therefore, nanotechnology based approaches,
especially nanoemulsion, a non-spontaneous, transparent or translucent, kinetically stable nanostructured
(1-1000nm) colloidal dispersion (comprised of oil, water and surfactant/cosurfactant),
are being popularised as a potential topical nanocarrier to deliver BCS class II and
IV anti-neoplastic drugs attributing to its capacity for both active and passive tumor targeting in
controlled or sustained manner and improving bioavailability via enhancing permeabilityretention
effect with minimal adverse effects. Numerous research on nanoemulsion for the
treatment of both melanoma and non-melanoma skin cancer is only limited to preclinical stages
as several physiological variables reduce the effectiveness of nanoemulsion via restricting topical
penetration.
The Association between Cadmium Exposure and Thyroid Function in Animals: A Systematic Review
Authors: Nazarian Maryam , Mohammadparast Tabas Pouria , Harifi-Mood Mohammad Sadra , Aramjoo Hamed , Bavali-Gazik Ahmad , Saberi Amirhossein , Peyghambari Yasaman , Mohammadparast-Tabas Peyman , Anghoshtary Amirhosein , Samarghandian Saeed , Farkhondeh Tahereh
Published: July 2024

Background:

Several studies have indicated an association between
cadmium (Cd) exposure and the induction of thyroid dysfunction in animal models.

Objective and Aims:

There are inconsistent findings on the effect of Cd on the thyroid
gland. Therefore, this systematic study was designed to determine the association
between changes in thyroid function markers and Cd exposure in animals.

Method:

The search was performed on Scopus, PubMed, Web of Science and
databases, and Google Scholar until May 2023. Studies on the relationship between
Cd exposure and fish's thyroid function were conducted on rodents and fish.

Results:

In total, 171 articles were obtained from the main databases using the search
strategy mentioned in this study. Finally, 24 articles were selected according to our
inclusion criteria for systematic studies. The findings indicated an increase/decrease or
no change in triiodothyronine (T3), thyroxine (T4), and thyroid stimulating hormone
(TSH) levels in rodents, fish, and animals exposed to Cd. Conclusion: Our findings
indicated an association between Cd exposure and thyroid dysfunction in rodents, fish,
and other animals. However, the association between urinary and blood Cd levels and
thyroid function remains unclear in humans because of controversial findings and a
lack of strong mechanistic evidence. We perform large cohort human studies to the
answer to this question.
SkinLiTE: Lightweight Supervised Contrastive Learning Model for Enhanced
Skin Lesion Detection and Disease Typification in Dermoscopic Images
Authors: Alzahrani Salha M.
Published: July 2024

Introduction:

This study introduces SkinLiTE, a lightweight supervised contrastive learning model tailored to enhance the detection and typification of skin
lesions in dermoscopic images. The core of SkinLiTE lies in its unique integration of supervised and contrastive learning approaches, which
leverages labeled data to learn generalizable representations. This approach is particularly adept at handling the challenge of complexities and
imbalances inherent in skin lesion datasets.

Methods:

The methodology encompasses a two-phase learning process. In the first phase, SkinLiTE utilizes an encoder network and a projection head to
transform and project dermoscopic images into a feature space where contrastive loss is applied, focusing on minimizing intra-class variations
while maximizing inter-class differences. The second phase freezes the encoder's weights, leveraging the learned representations for classification
through a series of dense and dropout layers. The model was evaluated using three datasets from Skin Cancer ISIC 2019-2020, covering a wide
range of skin conditions.

Results:

SkinLiTE demonstrated superior performance across various metrics, including accuracy, AUC, and F1 scores, particularly when compared with
traditional supervised learning models. Notably, SkinLiTE achieved an accuracy of 0.9087 using AugMix augmentation for binary classification of
skin lesions. It also showed comparable results with the state-of-the-art approaches of ISIC challenge without relying on external data,
underscoring its efficacy and efficiency. The results highlight the potential of SkinLiTE as a significant step forward in the field of dermatological
AI, offering a robust, efficient, and accurate tool for skin lesion detection and classification. Its lightweight architecture and ability to handle
imbalanced datasets make it particularly suited for integration into Internet of Medical Things environments, paving the way for enhanced remote
patient monitoring and diagnostic capabilities.

Conclusion:

This research contributes to the evolving landscape of AI in healthcare, demonstrating the impact of innovative learning methodologies in medical
image analysis.
Extraction, Isolation and Characterization of Bioactive Compounds from Euphorbia neriifolia (L.) Leaf and Evaluation of their Antioxidant Activity
Authors: Chaudhary Priya , Singh Devendra , Meena Mukesh , Janmeda Pracheta
Published: July 2024

Background:

Amidst the identification of numerous secondary chemicals from Euphorbia
neriifolia, there is a desperate need for the development of primary metabolite separation techniques.

Objectives:

In order to do that, bioactive chemicals from Euphorbia neriifolia (L.) leaf were extracted,
isolated, and characterized. Subsequently, their antioxidant activity was evaluated.

Methods:

In this study, the determination of linoleic acid (LA) in petroleum ether extract (PEE) of
Euphorbia neriifolia leaf (ENL) was carried out the first time by using thin-layer chromatography
(TLC) and high-performance thin-layer chromatography (HPTLC) methods.

Results:

The chromatographic analysis of the PEE of ENL shows better spots and well-separated
peak of LA with 0.49 retention factor (Rf) value and 22.54 ng LA content. The linearity of the calibration
curve ranges from 5-25 ng/spot with a high correlation coefficient. The proposed method was
characterized by better accuracy close to 99.5%, well robustness, and good precision range from
0.183% (intra-day) to 0.242% (inter-day). The percentage (%) RSD, which determined the stability
of standard LA, did not exceed 2% after time period of 12, 24, 36, 48, and 72 h. The GC-MS analysis
revealed the presence of different types of low or high-molecular-weight phytocompounds of varying
quantities from the fractions of ENL. The FT-IR spectrum of ICs showed various peaks that confirmed
the presence of C=C bending, C-H stretching, O-H stretching, CH2 stretching, and a carboxyl
group. The 1H-NMR spectrum of the ICs from ENL confirmed the presence of octadecanoic in IC1,
L-(+)-ascorbic acid dihexadecanoate in IC2, hexadecanoic acid in IC3, linoleic acid in IC4, and oleic
acid in IC5, respectively. IC-4 showed greater antioxidant activity in comparison to other compounds
with an IC50 value of 3.9 ± 0.01 μg mL-1.

Conclusion:

Thus, the present study identified five different phytocompounds that may be utilized as
an effective option for the cure of different diseases.
Advancements in Natural Alkaloid-Loaded Drug Delivery Systems for Enhanced Peptic Ulcer Treatment: A Review
Authors: Shahin Nagma , Jain Parag , - Ajazuddin , Nagori Kushagra
Published: July 2024

Peptic ulcers, which damage the gastrointestinal tract lining, are a significant global health
issue. The traditional approaches to treating peptic ulcers have poor bioavailability, unstable formulations,
and undesirable side effects. Natural alkaloids have garnered increased interest as potential
therapeutic agents in recent years due to their diverse pharmacological actions and decreased toxicity
profiles. This manuscript summarizes recent progress in natural alkaloids for peptic ulcer treatment,
highlighting new drug delivery methods. Natural alkaloids, originating from different plants, have
anti-inflammatory, antioxidant, and antibacterial properties, potentially accelerating the healing of
peptic ulcers. Moreover, medicines don't always function properly because they degrade too fast,
don't dissolve well, and have other problems, such as insufficient bioavailability. Creative liposome
delivery systems, microspheres, nanocarriers, and other customized delivery strategies have shown
promise in overcoming these barriers. By distributing the medication gradually and precisely, these
innovative techniques improve the medication and effectiveness at the ulcer site. As a result, natural
ingredients work better and provide better treatment results.
Gender Incongruence: Prevalence and Therapeutic Options Among
Transsexuals Belonging to a Single Center
Authors: Vetri Mario Giuseppe , Greco Annamia , Tobino Cinzia , Rapisardi Giovanni , Grasso Giuseppe , D'Agata Anna Maria
Published: July 2024

Aim:

This study aimed to describe characteristics and treatment choices among AMABs
(Assigned Male At Birth) and AFABs (Assigned Female At Birth) transgenders enrolled
from March 2021 to July 2023 at the PTA S. Giorgio of the ASP3-Catania

Case History:

A total of 145 patients were studied, and there was no prevalence of
AMAB/AFAB. At first observation for AMABs, the age was 26 years and 25 years for AFABs,
with 11 AMAB/AFAB declared as "non-binary" (average age 17 years).

Results:

In AMAB/AFAB, we evaluated hormonal treatment, efficacy, and dosage/hormonal
levels. In AMABs, oral estradiol valerate (4 mg/day) or transdermal estradiol in gel (2 mg/day)
+ oral cyproterone acetate (25 mg/day) for both estrogenic formulations were used. Testosterone
(TE), LH, FSH, and PRL at baseline and during chronic treatment were measured. In
AFABs, we used injectable TE (250 mg/3-4 weeks or 1 g/12-16 weeks) or transdermal TE (60-
80 mg/day). In these patients, we analyzed blood count, LH, FSH, and TE. Hematocrit, hemoglobin,
and red blood cell count showed a modest elevation after 4-6 months of treatment.
About 32% of AFABs complained of transient uterine bleeding, but no hypertension or ovarian
pathology was detected.

Conclusion:

In AMABs, despite the short observation period, no patient showed an increased
risk of myocardial infarction and ischemic stroke. Among AFABs, no increased risk of cardiovascular
or cerebrovascular disease was observed. Furthermore, given the complexity of the
phenomenon, the integration between the different professional figures who require specific and
qualified skills is fundamental.
El tamaño de las operaciones de diseño en arquitectura y pintura
Authors: Guerri Claudio , González Carlos G.
Published: July 2024

El control de la forma mediante algún recurso geométrico es una actividad realizada por todos los artistas o diseñadores desde tiempos inmemoriales. Durante milenios, el uso de algún tipo de trazado regulador se limitó a controlar los aspectos formales siempre dentro de los límites del propio objeto. Solo a fines del siglo pasado, con la creación del tercer lenguaje gráfico —el TDE o Proyecciones Geométricas Relacionales—, se puede demostrar que, en realidad, los trazados reguladores trascienden los límites físicos de la obra arquitectónica o pictórica. Esta nueva posibilidad de lectura e interpretación de las obras produce información estética, técnico-gramatical y valorativa para el estudiante, el diseñador o un curador.
Diseño-arte-ciencia: perspectivas transdisciplinares en ámbitos de la formación doctoral
Authors: Londoño L. Felipe César , Gómez Alzate Adriana
Published: July 2024

Diseño, arte, ciencia: perspectivas transdisciplinares en ámbitos de la formación doctoral presenta los procesos investigativos que se han llevado a cabo para proponer y estructurar un programa de formación doctoral de carácter latinoamericano en el contexto de indagaciones disruptivas que le apuestan a la innovación educativa. El propósito de integrar diseño-arte-ciencia implica conceptualizar una idea que transforma una tradición investigativa y académica centrada en las divisiones disciplinares del conocimiento para, a partir de diálogos transversales, generar confluencias entre ámbitos de la tecnología, la ética de la vida, la estética de las acciones y los avances científicos que conllevan a que, en conjunto, las investigaciones aporten a la solución de los grandes problemas, para una regeneración socioambiental.
 
En esta línea, el nuevo programa doctoral se estructura a partir de la voluntad de consiliencia, un concepto instaurado por William Whewell en La filosofía de las ciencias inductivas ([1840] 2017) y posteriormente profundizado por el biólogo humanista Edward Osborne Wilson, quien describe en Consilience: la unidad del conocimiento (1999) la necesidad de entender que un campo del saber estudia un subconjunto de la realidad que depende de factores estudiados por diversas disciplinas para su comprensión holística. Este propósito de integración de saberes ya había sido abordado por C. P. Snow en su polémico libro Las dos culturas y la revolución científica (1988), el cual abre el paso a discusiones futuras en torno a la necesidad de unir conocimientos y cerrar brechas entre las ciencias y las humanidades, para una mejor comprensión de la sociedad.
 
Los debates en torno a la consiliencia, así como la intención misional de la Universidad de Bogotá Jorge Tadeo Lozano de extender los trabajos iniciados en arte y ciencia desde la Expedición Botánica en Colombia, las experiencias recopiladas durante 26 años en eventos como el Festival Internacional de la Imagen y los procesos de creación e investigación llevados a cabo por personas vinculadas a la Red MediaLab Brasil de la Universidad Federal de Goias, la maestría en Diseño Interactivo de la Universidad de Buenos Aires, el Museo de Arte Contemporáneo, la maestría en Artes Mediales de la Universidad de Chile y la Cátedra Max Aub Transdisciplina en Arte y Tecnología de la Universidad Nacional Autónoma de México hicieron posible concretar esta propuesta doctoral en Diseño, Arte y Ciencia que hoy se oferta en la Universidad de Bogotá Jorge Tadeo Lozano. Este artículo también retoma los debates llevados a cabo en EDUMMET-Encuentro Internacional de Intercambios de Aprendizaje, que se realizó en Madrid, España en el año 2022.
Xenofuturismo. Figuraciones decoloniales del futuro a partir de semioversos vernáculos
Authors: Voto Cristina , Martin-Iglesia Rodrigo , Agra Rocío
Published: July 2024

El objetivo de nuestra investigación es cuestionar las narrativas del futuro del Norte Global a través de construcciones semióticas vernáculas alternativas. Analizaremos el impacto que los semioversos vernáculos americanos tienen en la posibilidad de generar figuraciones decoloniales de futuros alternativos, basándonos en el marco teórico de lo que denominamos xenofuturismo. Arraigado en América Latina, el xenofuturismo tiene dos vertientes complementarias: la recuperación de una memoria activa de la deconstrucción decolonial y la comprensión de la alteridad radical. Dentro de estos semioversos, exploraremos las figuraciones culturales aymaras, para las que el futuro no está delante sino detrás, desorientándonos del presente, única dimensión temporal en la que existimos. La idea de futuro-pasado, o de que el pasado puede ser visto como futuro, deviene entonces central. Esta hibridez temporal desgarra la linealidad del tiempo y perfila la emergencia de figuraciones del futuro que contienen una densidad de tensiones temporales en el presente.
Az alternatív fehérjét gyártó vállalkozások jellemzői
Authors: Szenderák János
Published: July 2024

Excessive consumption of animal-based protein has led to a significant negative impact on the environment and human health. Companies producing alternative protein end-products aim to produce substitute products that are similar to conventional animal-based products with less environmental impact. In this research, 955 alternative protein companies were analyzed using descriptive methods. The results revealed a significant increase in the number of companies after 2015, indicating high industry potential and an increasing global focus on sustainability. Plant-based products dominated the production structure because they were more appealing to consumers and may reach price parity sooner. Current food systems are unsustainable. Thus, although some factors still hinder the market uptake of alternative proteins, a shift towards a more sustainable food system is inevitable in the future.
The probable impact of policies and policy measures on globalisation
Authors: Losoncz Miklós
Published: July 2024

This paper aims to identify the impact of the recent economic and non-economic shocks on the globalisation of trade in terms of trade policy and structural openness, and to take a side in the discussion about the reversal, the slowdown, and the continuation of trade globalisation. The report argues that geopolitical decisions based on pure political priorities and different macro- and micro-policies may harm trade globalisation temporarily. Nevertheless, in the long run, underlying economic factors, such as decreasing trade costs and expanding services trade remain the critical driving forces of globalisation. The speed of the process is likely to be slower than before, and its characteristics are different. With weakening multilateralism and increasing fragmentation, the emerging global world order will be suboptimal from the point of view of economic efficiency. 
Journal of Economic Literature (JEL) codes: F01, F02, F13, F60.
The cross-talk between autoimmune diseases and sarcopenia (Preprint)
Authors: Gao Yue , Zhang Yingjuan , Wu Qingqian , Chen Qingyan , Wang Yi , Li Bei , Zhao Qingwen , Wang Qianzhuo , Wang Yule , Han Shuang
Published: July 2024

UNSTRUCTURED

With the coming of aging society, the prevalence of sarcopenia increases rapidly. Sarcopenia is a progressive, generalized reduction in muscle mass, muscle strength, and physiological function accompany aging and it is a risk factor for many metabolic diseases. Previous studies found that immune cells take part in the whole process of muscle regeneration. Autoimmune diseases are a series of related diseases characterized by dysregulation of immune system, which could lead to inflammation and multi-tissue damage. Meanwhile, autoimmune diseases have a negative effect on the physiologic behavior of the skeletal muscles, which could exacerbate and accelerate the occurrence of sarcopenia. Among all of the autoimmune diseases, type 1 diabetes mellitus, rheumatoid arthritis, and inflammatory bowel disease are the three common immune diseases, and the interaction between them and sarcopenia is more likely to lead to adverse clinical outcomes, poor effects of drug treatment and prognosis, low quality of life, and the patients would under huge financial pressure. Thus, a comprehensive analysis of the relationships between the three autoimmune diseases and sarcopenia will help us better understand the potential mechanism, explore more effective treatments, guide clinical care and reduce complications. Moreover, it also provides new thinking for future scientific research.
A Informal Sector Self-Employed Workers’ Old Age Pension Scheme in Retail Sector in Zimbabwe
Authors: Makochekanwa Albert , Cheure Cheure , Chundu Moses , Mavodyo Elisha
Published: July 2024

The high incidence of informality in Zimbabwe implies that a large proportion of the adult population does not have access to contributory pension schemes during their working lives, rendering them ineligible for old-age pensions. The primary goal of this research is to develop a pragmatic informal retail sector noncontributory old-age pension scheme in Zimbabwe. The study drew empirical evidence from a comprehensive countrywide study using mixed-methods research. The study concluded that several factors, including the respondents' demographic characteristics, are important considerations in developing an effective non-contributory old-age informal sector pension scheme. Based on the study's findings, the study proposes alternative non-contributory old-age informal sector pension schemes, such as financing the non-contributory old-age social pension, determining the monthly amount of a non-contributory old-age pension, and gradually covering a non-contributory old-age pension gap. The study recommends the introduction of a non-contributory informal sector retirement pension fully funded by the government.
Keywords: retail informal sector old-age pension scheme; social security; informal sector; Zimbabwe.
Practical Exploration of Net-Zero Building Technology in Hot Summer and Cold Winter Regions—Qingdao Sino-German Eco-Park Longfor Guangnian Project as an Example
Authors: Jing Wang , Lijuan Chen , Huili Cao , Miaomiao Liu , Qianqian Cheng , Chuanli Yang , Yibo Li
Published: July 2024

Energy saving and carbon reduction in the building sector is crucial to the realization of China’s “double-carbon” goal, and the development of passive house/net-zero buildings is an important initiative to achieve this goal. This paper takes Longfor Guangnian, a passive house project in Qingdao, as a case study, summarizes the technical practice of net-zero buildings in coastal areas with hot summers and cold winters, and gives an optimization plan in combination with the existing problems of the case. The final result is to improve the building energy efficiency and optimize the building energy structure. It accumulates experience and provides reference for the promotion of net-zero buildings in cold areas, and provides support for green and low-carbon development in the field of housing and urban-rural construction.
Risk Reduction and Recovery from Flood Hazard- A Case of Human Adjustment in Lower Damodar Basin, West Bengal
Authors: Mandal Lipika
Published: July 2024

The study investigates the risk of flood hazards in the lower Damodar basin, focusing on human perception and adjustment strategies to mitigate and recover from the societal risk posed by these hazards. The river Damodar is known as ‘the sorrow of Bengal’ due to its flood ravages in the entire Damodar valley, which caused much unhappiness and distress in the lower Damodar region. In this area, the main flood-causing agents are rainfall and discharge from upland reservoirs. In the study, the annual peak flow is used to determine the flood frequency analysis. Flood inundation mapping analysis revealed that Amta and Khanakul blocks of Hooghly district are most vulnerable to maximum flood inundation during monsoon months. The damage due to floods in terms of economic loss and the probability of flood occurrences are used for assessing flood risk and the magnitude of vulnerability in the study area. The adopted structural measures in this area have not yielded sufficient results to mitigate the chronic flood problems. Therefore, some non-structural measures, particularly human adjustment strategies, are taken into consideration, like flood forecasting, alternative cropping arrangements, choices for other livelihood options, and capacity building through self-help- groups.
Production of Indole Acetic Acid from soil bacteria: A alternative approach on plant growth
Authors: Chudiwal Anupriya ,   Institute of Biosciences and Technology, MGMU Chh. Sambhajinagar, Nalawade Atharva ,   Institute of Biosciences and Technology, MGMU Chh. Sambhajinagar
Published: July 2024

Indole acetic acid (IAA) production is a major assets of rhizosphere bacteria that stimulate and enhance plant growth. The present work deals with isolation and identification of indole acetic acid producing bacteria from the rhizosphericsoil collected from Pomegranate, Guava and Amla farm. Out of ten Indole acetic acid producing isolates, two wereselected as efficient producers. Spectrometric analysis of IAA was done after 24, 48 and 72 hours of culture whichshowed that the isolated bacteria produced maximum concentration of IAA after 72 hours of incubation period at 37°C. The concentration was measured using a standard IAA curve and the maximum concentration was obtained byAA2. Subsequently, effect on plant growth was tested by pot assay. The in vitro treatment of pea seeds with AA2isolate for germination showed better result than control. In conclusion the study suggests the IAA producing bacteriaas efficient inoculants to promote plant growth. Keywords: rhizobacteria, IAA, pot assay plant growth
Cayley fuzzy graphs on groups
Authors: Jisha Mary John , Riyas A. , Geetha K.
Published: July 2024

We investigate some properties of Cayley fuzzy graphs on groups in terms of algebraic structures. And we also discuss the connectedness on it. In this paper, we prove that the Cayley fuzzy graph induced by (Zm × Zn, +, ν) is the disjoint union of Cay (aH, R) provided ν(h) > 0 ∀ h ∈ H and ν(h′) =0 ∀ h′∈ Zm × Zn\H, where H is the cyclic subgroup of order n in Zm × Zn.
On the right automorphic generalised Bol loops
Authors: Abdulkareem Abdulafeez Olalekan , Oyebo Y. T. , Adeniran J. O.
Published: July 2024

This study centers on right automophic generalised Bol loops. Having established the generators of inner mapping group of generalised Bol loops, some properties of generalised Bol loops, in terms of right translation map, are obtained. These properties are later used to established a condition under which right automorphic generalised Bol loop is a generalised Moufang loop.
Induced dominating sequence and ESD graphs
Authors: Alex Liju , Mullor John Joy , Gopalapillai Indulal
Published: July 2024

A vertex subset D of a graph G = (V,E) is said to be a dominating set if every vertex in G is either in D or adjacent to some vertex in D. The minimum cardinality of such a set is the domination number, which is denoted as γ(G). In this paper, we define a sequence associated with the domination concept in graphs and studied the basic properties of the sequence in terms of various parameters of graphs. Using this sequence we order the vertices of a dominating set according its significance and propose Equally Significant Dominating (ESD) graphs. We also introduced domination related topological indices and compute their lower bounds for trees, unicyclic graphs and bicyclic graphs. All the graphs attaining the bounds are characterized.
Diez años de investigación educativa sobre discapacidad en México y prospecciones
Authors: Gajardo Espinoza Katherine , Hernández-Tapia María Cristina , Campos-Bedolla Mónica Leticia , Zardel Jacobo Blanca Estela , Salazar Silva María de Lourdes , Cáceres-Iglesias Judith
Published: July 2024

La investigación sobre el acceso a la educación para personas con discapacidad en México ha correspondido con la evolución global del tema. Este artículo tiene como objetivo describir los temas y enfoques teóricos más comunes de la investigación educativa en torno a la discapacidad, discriminación y exclusión en México durante los últimos diez años, así como su prospectiva. Para ello, se exponen los resultados de una revisión sistematizada de la literatura, especialmente la publicada en revistas científicas entre 2013 y 2022. Los resultados muestran que las metodologías más utilizadas son las cualitativas, las cuales muestran un interés en las prácticas, actores y contextos relacionados con los derechos humanos. Además, aunque sigue siendo predominante el enfoque médico-rehabilitador, se observa un acercamiento al enfoque crítico e inclusivo. Se hace un llamado a realizar investigaciones centradas en la persona, no en la discapacidad.
La gestión del conflicto en la Universidad Complutense de Madrid
Authors: Dorado Barbé Ana Isabel , González Casas David , Noa de la Fuente Roldán Iria , Ducca Cisneros Linda Vanina
Published: July 2024

El objetivo del presente artículo es analizar las experiencias del alumnado complutense en relación con la gestión del conflicto en el contexto universitario. Para ello, se realizó un estudio cualitativo en el que se desarrollaron seis grupos focales con 45 alumnos de la Universidad Complutense de Madrid que participaron de manera voluntaria. Los resultados obtenidos muestran cómo los conflictos más habituales son los que se generan con el profesorado, los cuales son motivados, principalmente, por situaciones de poder, discriminación, conciliación laboral/universitaria, organización docente y rigidez administrativa. Asimismo, el estilo de afrontamiento más habitual es el evitativo; mientras que las propuestas de mejora derivadas de las experiencias analizadas se orientan a aumentar la participación y el protagonismo del alumnado en los sistemas de gestión de conflictos y a incluir asignaturas/competencias transversales de mediación.
La cualidad multicultural de los espacios de aprendizaje en la educación superior
Authors: González Hernández Walfredo
Published: July 2024

El aprendizaje de los estudiantes transcurre en diferentes lugares, como los museos y los espacios virtuales, entre muchos otros, por lo que el concepto de espacio de aprendizaje permite caracterizar todas las áreas donde se puede aprender en cualquier nivel educativo. En estos espacios el estudiante puede aprender de varias culturas, incluso en las aulas, donde se dan encuentros culturales desde lo individual hasta lo social. Por ello, el objetivo de este artículo es argumentar la cualidad multicultural de los espacios de aprendizaje donde el estudiante se implica para aprender. En el cuerpo del artículo se analizan los conceptos de cultura y su relación con el aprendizaje, que permitirán analizar, en un segundo momento, la multiculturalidad en los espacios de aprendizaje escolarizados y no escolarizados. Por último, se abordan los espacios de aprendizaje cuyos integrantes provienen de culturas diferentes y las relaciones que se pueden establecer.
La Metodología de la Ciencia Básica del Derecho y la Investigación Parlamentaria.
Authors: Álvarez León José Antonio
Published: July 2024

En el presente escrito se desarrollará el esquema básico del proceso de investigación centrado en el emparejamiento de la estructura del protocolo de investigación con los pasos del método científico, lo cual permitirá al jurista y al legislador poder guiarse de forma más sencilla en el camino complejo de la investigación. Se abordará de forma novedosa el acercamiento de los métodos, técnicas y contenidos justificadores usados en la ciencia jurídica dentro de los procesos de investigación social para poder proyectar productos legislativos. No se pretende ser reiterativo de lo que ya se ha dicho o escrito en varios textos, de hecho se seguirán algunos conceptos tradicionales pero con las aplicaciones en la ciencia jurídica.
Law and Policy for the Quantum Age
Authors: Palacios Garita Rene
Published: July 2024

En los tiempos que corren, nos enfrentamos al fenómeno denominado la cuarta revolución industrial y los retos de la época demandan a los estudiosos del derecho herramientas adecuadas para hacer frente a la realidad de nuestros días. Un problema fundamental para el gremio está relacionado con discernir el impacto disruptivo de las tecnologías en general, y en particular, la tecnología cuántica, de manera que se maximicen los beneficios potenciales a la par de la potencialización de importantes aspectos como los derechos humanos. Esto teniendo como moción la mitigación de riesgos y la protección de los valores fundamentales de la sociedad en un entorno tecnológico en constante evolución.
Enhanced Diabetes Prediction and Monitoring through Integration of Multimodal Data Using XGBoost
Authors: Pandey Asheesh
Published: July 2024

Abstract: Diabetes is a critical and become more complicated disease that can cause serious health problems if it is not adequately managed. The early diagnosis and treatment of diabetes is a critical component of the condition that can be greatly aided by data analysis and predictive algorithms. Through the use of data mining techniques, such as classification and prediction models, it is possible to analyse various elements of diabetes data and extract useful information that can be used for the early detection and prediction of the condition. One machine learning technique that can effectively and highly precisely predict diabetes is the XGBoost classifier. This method makes use of the gradient-boosting architecture and can handle large and intricate datasets with independent high-dimensional feature sets. Conversely, it is crucial to remember that the choice of the best algorithm for diabetes prediction could depend on the specifics of the data as well as the area of study being investigated. Data analysis and prediction methods can be applied not only to anticipate diabetes but also to monitor the disease's progression, find risk factors for diabetes and its complications, and assess the effectiveness of treatment. By using these techniques, medical professionals can obtain important insights into the disease's underlying causes, which helps them make informed decisions about patient management. The early detection and management of diabetes, a chronic disease that is rapidly expanding and poses major health risks, has the potential to be significantly improved through the application of data analysis and prediction algorithms. An accuracy rate of 89% was achieved by the XGBoost classifier, which demonstrated the highest level of performance.