bluuebunny/crossref_metadata_2025 huggingface dataset:
Optimization of treatment and prevention of recurrence of bacterial vaginosis and vaginal candidosis in women of reproductive age
Authors:   Vinnitsa national medical University M. I. Pirogov, Vaskiv O.V. , Gorbatyuk O.G. ,   Vinnitsa national medical University M. I. Pirogov, Grigorenko A.P. ,   Vinnitsa national medical University M. I. Pirogov, Shatkovskaya A.S. ,   Vinnitsa national medical University M. I. Pirogov, Medvedev V.O. ,   Khmelnitsky State Perinatal Center
Published: March 2022

The article deals with the problem of optimization of treatment of bacterial vaginosis and vaginal candidiasis in women of reproductive age. A comparison of the results of the use of the drug Hexicon in women with bacterial vaginosis and vaginal candidiasis during menstruation and during the rest days of the menstrual cycle has been performed. The reliable high efficiency of the use of the drug Hexicon for the treatment and prevention of relapse of bacterial vaginosis and vaginal candidiasis from the first day of the menstrual cycle, that is, during menstruation, has been proven. Key words: bacterial vaginosis, vaginal candidiasis, Нexicon.
Dental Care Utilization Among Adults Aged 18−64: United States, 2019 and 2020
Authors: Cha Amy , Cohen Robin
Published: March 2022

This report uses data from the 2019 and 2020 National Health Interview Survey to describe recent changes in the prevalence of dental visits among adults aged 18−64.
Site classification of seismic recording stations of Garhwal region of earthquake early warning system for Uttarakhand, India
Authors: Kumar Pankaj , Kumar Pankaj , Pandey Bhavesh , Kamal  , Kumar Ashok
Published: March 2022

Site classification is vital to carry out seismic hazard analysis of a region and get the damage patterns caused by earthquakes. In the present study, the ground motion of earthquakes recorded from 2015 to 2019 at 84 sites of the seismic network array of Earthquake Early Warning System for Uttarakhand are analyzed for site classification purposes. The predominant period from the mean horizontal to vertical spectral ratio curves was estimated. The classification schemes devised by Japan Road Association and National Earthquake Hazards Reduction Program are applied to classify the sites. Along with this, two other site classification indexes schemes are also applied for classification purposes. Data winnowing techniques are used over the ground motion records to pick out desirable quality records. Conclusively, the site class with the highest recurrence rate amongst the used methods is selected as the final class for that particular site. The effect of magnitude, distance and depth on horizontal to vertical spectral ratio are described and concluded that these factors do not significantly affect the ratio curves. The average horizontal to vertical spectral ratio curves obtained for all the sites matches well with the existing literature. The classification of a few sites are verified from the classification done by other methods in recent studies. It is evident from the results that the classification done in this study matches well with them.
Digitalization of Tax Administration: Modern Model and Development Prospects
Authors:   Volgograd State University, Ksenda Viсtoria
Published: March 2022

The dominant technological trend of the 21st century is the Fourth Industrial Revolution (Industry 4.0). Based on robotization (automation) and digitalization of processes, it has embraced the entire advanced world community. Modern humanity has adapted to a technologically innovative way of life and actively uses social networks, messengers, distance learning formats, GPS navigation, online commerce, online government services, Internet banking, etc. Economic relations are no exception. Digital transformation has affected the financial system, on the one hand, by modifying concepts, models, methods, mechanisms, tools, and providing convenience, saving time, and security on the other. Contactless interaction becomes the basis of tax relations. The tax administration system, based on strict norms of the law, operates in a digital environment, which simplifies the procedures of interaction with taxpayers. The purpose of the work is to consider the processes of digitalization of tax administration, which will allow us to form a model and principles of the current tax administration system. For this purpose, the article examines the existing electronic services and tax administration programs, presents their classification, and identifies development prospects. The modern model of the tax administration system based on the principles of transparency of the interaction of subjects of tax relations, the functional conjuncture of the fulfillment of tax obligations, the condition and quality of services provided in a digital environment contributes to the achievement of the targets of the budget system, as well as national goals and priorities of the development of the state.
Analysis and Estimation of the Efficiency of Regional US Innovative Systems
Authors:   Ryazan State Agrotechnological University named after P.A. Kostychev, Minat Valerij
Published: March 2022

The study is based on methods of analysis and subsequent assessment of the effectiveness of regional innovation systems operating at the US state level, used by both Russian and English and American specialists. Based on statistical data and the results of previously published works by the author, revealing the empirical essence of the spatially heterogeneous innovation activity of the United States, characterized by the corresponding indices and integral indicators, an assessment of the effectiveness of regional innovation systems of each US state is given. Based on the results of the analysis using a number of methodological categories, carried out in the context of the country’s subregions, the author put forward some provisions justifying the spatial heterogeneity and unevenness of the development of US innovation activities in 2015–2019 from the standpoint of assessing the effectiveness of regional systems. The undertaken hierarchical clustering of regional innovation systems reflects a five-member diversity that characterizes, first of all, inventive efficiency in the spatial context of the United States, which takes various options depending on the qualitative characteristics of the scale and boundaries of various factors of innovation activity.
The Need to Change the Priorities of Monetary Policy
Authors:   Tambov State University named after G.R. Derzhavin, Sutyagin Vladislav , Radyukova Yana ,   Tambov State University named after G.R. Derzhavin
Published: March 2022

The sanctions standoff, the growing global crisis, and the pandemic have exacerbated the issues of stimulating economic growth and investment activity. This study is based on data from the IMF, Rosstat, the Bank of Russia, and the Rand Corporation. This study is based on the publications of a number of foreign and Russian scientists. It analyzes the dynamics and structure of investments in fixed assets, GDP, money supply (monetary aggregate M2), the rate of inflation, and the key interest rate. In the course of the analysis, the dynamics of GDP growth, money supply, and the monetization coefficient of the leading economies, including Russia, were analyzed. In the course of the study, the regularities, features and limits of monetization were established. The results of the study can be used to further substantiate the necessity and expediency of the monetary policy vector, as well as to develop tools for channeling the money supply. The study revealed that the sanctions regime is formed by noticeable problems with attracting foreign investment. The latter leads to a decline in investment activity and stagnation in the economy. In this situation, it is necessary to change the priorities of monetary policy.
Interregional Cooperation: Experience of the Regions of the European North of Russia
Authors:   Vologda Research Center of the Russian Academy of Sciences, Kozhevnikov Sergey , Sekushina Irina ,   Vologda Research Center of the Russian Academy of Sciences
Published: March 2022

Interregional cooperation is not only one of the key factors of economic growth, but it also ensures the preservation of the single economic space of the country. The purpose of the study is to analyze interregional interaction between the subjects of the European North of Russia. The article presents a theoretical overview of the works of domestic and foreign authors on this topic. The strategies of socio-economic development of the regions of the European North of Russia are considered in order to reflect the issues of interregional interaction in them. The existing cooperation agreements between the regions are analyzed. Content analysis of action plans for the implementation of these agreements is carried out on the example of the Republic of Karelia, Arkhangelsk and Murmansk regions. A brief overview of interregional projects implemented in the considered constituent entities of the Russian Federation is presented. Conclusions are drawn that the state authorities of the regions recognize the importance and necessity of developing interregional cooperation, but the main form of interaction is still the exchange of experience, as well as the holding of joint cultural and sports events. Not all regional socio-economic development strategies fully reflect the issues of interregional cooperation and possible prospects for its development. The obtained results contribute to the study of issues of interregional cooperation, can be used in the framework of the implementation of the state policy on the development of interregional ties, cooperation of regions to solve common problems in the economic and social spheres. As part of further research on this topic, it is planned to study interregional economic and cooperative ties, including in the implementation of joint investment projects.
Criminalization of the Economy As an Obstacle to Its Development: Problems and Solutions
Authors:   Academy of Management of the Ministry of Internal Affairs of Russia, Mikhaylova Nataliya , Timokhin Dmitriy ,   Moscow State University of Humanities and Economics, Shvetsova Ksenia ,   Academy of Management of the Ministry of Internal Affairs of Russia
Published: March 2022

The article proposes an assessment of the impact of criminalization of the economy on the systemic processes that ensure its development. The economic nature and reasons for criminalization of the economy are considered in accordance with the views of leading scientists, the interpretation of the theory of criminalization of the economy in terms of its influence on the disclosure of the potential of its economic development is carried out. The framework economic problems arising in response to the criminalization of the economy are identified, and the specifics of the manifestation of these problems in Russian realities are considered. The article assesses the scale of criminalization of economy in Russia in comparison with foreign economies and the resulting assessment of the impact of criminalization of domestic economy on parameters that are important from the standpoint of the global economy, as economic security, competitiveness of national producers and investment attractiveness of the economy in the global market is proposed. The most typical challenges for the Russian economy, associated with criminalization, have been identified. Significant differentiation of the problem under consideration on a regional basis has been proved. Statistical data for a homogeneous in terms of the degree of development region of the economic system were collected and analyzed, the dynamic impact of excesses of criminal nature on its economic development was determined. Based on the results of this work, proposals to intensify economic development by countering the systemic criminalization of the economy at the level of counteracting the factors that generate it were developed.
Analysis of the Competitiveness of Services of Hotel Enterprises Using the Parametric Method
Authors:   International Institute of Design and Service, Bodrova Ekaterina , Inyukina Aleksandra ,   International Institute of Design and Services
Published: March 2022

Many hotels appear on the market every year, which means that the competition between them also increases. Companies strive to introduce new products and services and improve existing ones in order to surpass competitors. There is an increasing need to assess the market situation. As a result, the importance of such a concept as competitiveness and methods of its assessment increases. The purpose of this article is to analyze the competitiveness of services of hotel enterprises (on the example of the Center-Hotel LLC) using the parametric method. As part of the expert evaluation, the parameters were determined according to the Regulation on the Classification of Hotels; the correspondence of the services of the Center-Hotel LLC and its competitors to the assigned category was revealed; the number of correspondences and the expression of the result as a percentage were calculated; the final assessment by type of services was formed. As part of the consumer evaluation, parameters were determined, weight was assigned to each parameter; the consumer ratings of the Center-Hotel LLC and its competitors were grouped in the form of an assessment/number of respondents; the sum of points/ratings was calculated taking into account the weight and the final assessment by type of services was formed. The article considers the sequence of parametric analysis, a modification of this method for hotel enterprises and an example of the application of analysis for a specific enterprise in the industry; the advantages and disadvantages of parametric analysis for hospitality enterprises are identified.
Mudanças e continuidades entre o Chile Solidario e o Ingreso Ético Familiar
Authors: Oliveira Maria Clara , Gonnet Cecilia Osorio
Published: March 2022

Resumo Este artigo apresenta e discute os programas de transferência monetária condicionada implementadas no Chile, o Chile Solidario (2002-2013) e o Ingreso Ético Familiar (2013-presente), procurando identificar continuidades e diferenças entre as duas iniciativas. Tendo por base a literatura sobre mudanças em políticas públicas e, em particular, a tipologia proposta por Howlett e Cashore (2009), que distinguem entre fins e meios, faz-se uma comparação entre os dois programas, de modo a identificar objetivos e mecanismos que se mantêm, quais se alteram, bem como as novidades introduzidas. Argumenta-se que, apesar de ter sido apresentado como um programa inovador em relação ao seu antecessor, o Ingreso Ético Familiar, o Chile Solidario mantém os atributos daquele, aos quais se adicionam alguns novos elementos. O artigo traz contributos em duas áreas: traça a evolução da política de transferência condicionada no Chile nas duas últimas décadas e dialoga com a literatura sobre mudança em política social.
Portocath insertion technique: retrospective study & step-by-step surgical description without tunneling in a high-complexity service
Authors: CARDOSO ANNA MARIA GARCIA , WENGROVER FERNANDA SANTOS , WÜRZIUS ALINE , PIETA MARINA PUERARI , CARLI RAFFAELA NASCIMENTO DE , DA-CUNHA CARLOS EDUARDO BASTIAN , BREIGEIRON RICARDO
Published: March 2022

ABSTRACT Objective: to demonstrate that the use of the portocath implantation technique without tunneling the catheter is not associated with a higher rate of complications in the short or long term. In addition, we aim to improve the implantation technique of the portocath device, with the presentation of a step-by-step guide for surgeons in training. Methods: this is a retrospective descriptive study, with analytical components. Data were analyzed using information extracted from electronic medical records linked to the National Health Care procedure code between the years 2019-2020. Results: none of the 94 procedures resulted in complications on the day they were performed. Complications were recorded seven days after the procedure in only two patients (2.13%). Intraoperative radioscopy had been performed in both cases. Thirty days afters the procedure, complications were observed in two patients among the remaining 92 (2.17%), both undergoing catheter implantation without tunneling. There were no complications in the six months after portocath implantation in 57.4% of patients and there is no information about the other 42.6%. Conclusion: the portocath insertion technique without tunneling is a safe outpatient procedure, with a low risk of complications, and can be adopted to shorten procedure time and patient discomfort, without functional or safety impairments. There was no association of not tunneling the catheter, laterality of the punctured vein and performing radioscopy in the transoperative period with the rate of complications.
Global Surgery at the National Landscape: Perspectives after the XXXIV Brazilian Congress of Surgery
Authors: CAMPOS LETÍCIA NUNES , SALGADO LUCAS SOUSA , VIANA SOFIA WAGEMAKER , BEZERRA ARISTÓCLES HÍTALLO , MISHALY ASHER , RIBEIRO LÍVIA SOUSA , YABRUDE ANGELA THERESA ZUFFO , AQUINO CAROLINE MARQUES DE , FERREIRA RODRIGO VAZ , FERREIRA JÚLIA LOYOLA , BOTELHO FABIO
Published: March 2022

ABSTRACT The XXXIV Brazilian Congress of Surgery included Global Surgery for the first time in its scientific program. Global Surgery is any action in research, clinical practice, and policy-making that aims to improve access and quality of care in surgical specialties. In 2015, The Lancet Commission on Global Surgery highlighted that five billion people lack safe, timely, and affordable surgical care. Even more critical, nine of ten people cannot access essential surgical care in low and middle-income countries, where a third of the worldwide population resides, and only 6% of global surgical procedures are performed. Although Brazilian researchers and institutions have been contributing to lay the movement’s foundations since 2014, Global Surgery remains a barely debated subject in the country. It is urgent to expand the field and break paradigms regarding the surgeons’ role in public health in Brazil. Accomplishing these standards requires a joint effort to strategically allocate resources and identify collaboration opportunities, including those from medical societies and regulatory bodies. As members of the International Student Surgical Network of Brazil - a nonprofit organization by and for students, residents, and young physicians focused on Global Surgery - we review why investing in surgery is cost-effective to strengthen health systems, reduce morbimortality, and lead to economic development. Additionally, we highlight and propose key recommendations to foster the field at the national level.
Safe ultrasound-guided percutaneous tracheostomy in eight steps and necessary precautions in COVID-19 patients
Authors: MENEGOZZO CARLOS AUGUSTO METIDIERI , SORBELLO CAROLINA CARVALHO JANSEN , SANTOS-JR JONES PESSOA , RASSLAN ROBERTO , DAMOUS SERGIO HENRIQUE BASTOS , UTIYAMA EDIVALDO MASSAZO
Published: March 2022

ABSTRACT Percutaneous tracheostomy has been considered the standard method today, the bronchoscopy-guided technique being the most frequently performed. A safe alternative is ultrasound-guided percutaneous tracheostomy, which can be carried out by the surgeon, avoiding the logistical difficulties of having a specialist in bronchoscopy. Studies prove that the efficacy and safety of the ultrasound-guided technique are similar when compared to the bronchoscopy-guided one. Thus, it is of paramount importance that surgeons have ultrasound-guided percutaneous tracheostomy as a viable and beneficial alternative to the open procedure. In this article, we describe eight main steps in performing ultrasound-guided percutaneous tracheostomy, highlighting essential technical points that can reduce the risk of complications from the procedure. Furthermore, we detail some precautions that one must observe to reduce the risk of aerosolization and contamination of the team when percutaneous tracheostomy is indicated in patients with COVID-19.
pyPEN: uma interface gráfica user-friendly para simulação Monte Carlo em física médica
Authors: Mendes H.R. , Massera R.T. , Tomal A.
Published: March 2022

A simulação Monte Carlo (MC) pode ser usada no ensino da física das radiações ionizantes com aplicações em física médica. No entanto, os códigos MC livres disponíveis não são user-friendly para usuários novos e inexperientes, limitando sua utilização como ferramenta educacional. Este estudo se concentra no desenvolvimento de uma interface gráfica user-friendly para simulações MC com foco no aprendizado de interação da radiação ionizante aplicada à Física Médica. A interface é um arquivo executável desenvolvido em Python 3.9. A interface serve como frontend para as simulações realizadas pelo código PENELOPE v. 2014 com a extensão penEasy v. 2015. Dois tipos de simulações são disponibilizados: (i) Tracking de partículas e (ii) Deposição de dose. Os resultados obtidos no caso (i) são apresentados graficamente em três figuras que mostram a trajetória de elétrons, fótons e pósitrons, respectivamente. Para o caso (ii), o resultado é a dose em função da profundidade de um volume na forma de caixa. Em resumo, esta interface, com geometria simples e simulações rápidas, em um ambiente interativo, oferece um grande leque de possibilidades para o entendimento da interação da radiação com a matéria, que é a base da física médica.
Dental management in the Intensive Care Unit in the treatment of toxic epidermal necrolysis associated with phenytoin: case report
Authors: RUPPEL Carolina , MARTINS Nathália Christina Stremel , FERREIRA Marceli Dias , CAMARGO Larissa , CLAUDINO Marcela , CAMPAGNOLI Eduardo Bauml
Published: March 2022

ABSTRACT Stevens-Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are adverse reactions, usually medicine-related, in which extensive and painful mucocutaneous lesions are formed. Oral lesions are characterized by the presence of erosions and ulcers. The treatment usually requires intensive care in a hospital setting, where the Dentist is essential in the multidisciplinary team, as he will act in the treatment of oral lesions. In this article, a 26-year-old female patient was reported, who presented TEN-compatible mucocutaneous lesions associated with the drug Phenytoin and required admission to a Teaching Hospital. The treatment consisted of the immediate suspension of the Phenytoin use and systemic therapy with corticosteroids and immunosuppressants. Oral lesions were monitored by the hospital dentistry team. The procedures adopted were: oral hygiene with 0.12% non-alcoholic Chlorhexidine Digluconate solution, hydration of the oral tissue with an essential fatty acid, application of frozen chamomile tea, and prescription of topical Triamcinolone Acetonide. Also, low-level laser therapy sessions (red and infrared) were performed. Oral lesions evolved with significant improvement. In this case, the importance of the Dentist in the multi-professional team is demonstrated. Although there is no protocol, the procedures used in the present case can be an alternative to therapies used in SSJ and TEN oral lesions.
Fuzzy system in a ferrous sulfate pre-treatment of elephant grass
Authors: Godinho Emmanuel Zullo , Caneppele Fernando de Lima
Published: March 2022

ABSTRACT Renewable energies have been occupying more and more space in energy matrices worldwide, and lignocellulosic biomasses are promising for these energy sources. This study aimed to develop a fuzzy model to optimize the ferrous sulfate concentration and temperature in the pre-treatment of elephant grass. Five concentrations (10, 15, 20, 25 and 30 mM) and three temperatures (25, 40 and 55 ºC) were used as input. The application of the fuzzy model evidenced that the best results for cellulose exposure (53.1 %) were achieved by using a ferrous sulfate concentration between 20 and 22.5 mM and temperature between 39.5 and 42.5 ºC.
Rural-urban Moatize: water harvesting design strategies to enable community-driven development
Authors: Paiva Júlia de Souza Campos , Barbosa Eliana Rosa de Queiroz
Published: March 2022

Abstract This paper presents design research on Moatize rural-urban area, located in the Zambezi river basin, Mozambique. The design research intended to find measures of conserving available resources, supporting reforestation and taking advantage of the riverscape to enlarge the landscape capacity. Starting with a vision of creating resilience through landscape design, the project worked within dualities of extremes: wet versus dry; rural versus urban; endogenous versus exogenous processes. This area is in a fast transformation process, mostly driven by foreign companies that negatively impact the environment and socio-economical dynamics. From an interdisciplinary analysis, problems related to water were identified as key issues to reduce community vulnerability and therefore, community’s reliance on outside interference. The design research proposes a water capture and distribution system, with small scale elements and a scattered management. As a result, the system can be better integrated with the landscape occupation, facilitating efficient community maintenance. The design process was a result of learning from local knowledge and applying it to infrastructural solutions, a soft-engineering project that can be built integrated to natural cycles. Since the project follows the principles of community driven development, it is not a final result, but the starting point of a discussion.
Da geotecnia para a gestão participativa: uma análise crítica de projetos de extensão universitária com foco na redução de risco de desastre
Authors: Sulaiman Samia Nascimento , Moura Rodolfo Baesso , Nogueira Fernando Rocha
Published: March 2022

Resumo A extensão universitária é o espaço-tempo propício para a articulação direta entre conhecimento científico e sociedade, vinculando inovação e compromisso social da Universidade. Com foco na temática urgente da Redução de Riscos e Desastres (RRD), este trabalho analisou e sistematizou conteúdos e métodos utilizados em quatro projetos de extensão desenvolvidos pelo Laboratório de Gestão de Riscos da Universidade Federal do ABC (LabGRis-UFABC) entre 2012 e 2021. Verificou-se um processo de evolução na abordagem teórico-metodológica sobre redução de risco e desastre (RRD) e a inserção de processos participativos de aprendizagem, que corroboram a linha evolutiva de quatro marcos internacionais em RRD: Yokohama (1994), Hyogo (2005), Sendai (2015) e os Objetivos do Desenvolvimento Sustentável (2015). Os resultados apontam o papel da Universidade em fazer a crítica ao fracasso das metodologias tradicionais, expresso na trágica persistência dos desastres a que se assiste, bem como o protagonismo dos atores locais por meio de processos de coprodução dos conhecimentos e compartilhamento das tomadas de decisões sobre os riscos, que são potencializados pela extensão universitária, como o caminho a seguir para comunidades seguras, resilientes e socialmente justas.
Dissolved organic matter photodegradation in a water supply reservoir on temperate oceanic climate (Cfb): a case study of Passaúna reservoir, Brazil
Authors: Souza Carolina Ferreira de , Knapik Heloise Garcia , Azevedo Júlio César Rodrigues de
Published: March 2022

Abstract Photodegradation is an important process for aquatic metabolism, related to the dissolved organic matter (DOM) transformation in water. For example, in a water supply reservoir, DOM is an important parameter since it can react and form disinfection by-products during water treatment. Thus, the understanding and determination of photodegradation rates are especially relevant for water resources management since they can influence DOM transformation in the water column. However, besides its relevance, few studies were conducted in the southern hemisphere for photodegradation rates determination. Therefore, we carried out field experiments to characterize and evaluate DOM photodegradation rate ‒ at different depths and in two solar irradiation periods ‒ through the application of absorption spectroscopy techniques in the UV-Vis region and fluorescence excitation-emission matrices (EEM) combined with the dissolved organic carbon (DOC) measurement. Low concentrations of natural DOM and nutrients in the aquatic environment were measured during the field monitoring. Our results indicate that photodegradation rates for a temperate oceanic climate reservoir were proportional to the availability of solar radiation, being more representative considering the time scale.
EDUCAÇÃO E MÍDIA: LEITURAS DE DESENHOS ANIMADOS NA ESCOLA
Authors: Pillar Analice Dutra , Telch Evalte Tatiana
Published: March 2022

Este artigo busca problematizar a leitura da visualidade contemporânea na escola, enfocando criações audiovisuais da mídia televisiva. Analisa, com base no referencial teórico e metodológico da semiótica discursiva, três episódios do desenho animado Bob Esponja Calça Quadrada, quanto aos efeitos de sentido produzidos na inter-relação das diferentes linguagens que os constituem, e as significações que as crianças lhes atribuem. Para conhecer as significações das crianças, foi constituído um grupo focal com uma turma de 4ª série do Ensino Fundamental que, após assistir cada um dos episódios, expressou suas leituras. Ao ler essas produções, as crianças relacionaram a fatos do seu cotidiano, tematizando-os. As conclusões evidenciam a importância de refletir sobre a visualidade contemporânea na escola, procurando apreender tanto seus efeitos de sentido como o que as crianças significam ao interagirem com tais produções; e apontam possibilidades de leitura de criações audiovisuais.
La lipoproteina (a): un fattore di rischio cardiovascolare complesso e polimorfo
Authors: Bianchi Alfio Ernesto , Maggi Antonio , Colombo Francesca , Raddino Riccardo
Published: March 2022

La Lipoproteina (a) [LP(a)] viene oggi ritenuta un emergente ed importante fattore di rischio cardiovascolare per la sua azione di tipo pro-aterogeno, pro-trombotico e pro-infiammatorio. L’incremento dei livelli plasmatici di LP(a) concorre a determinare un proporzionale incremento del rischio cardiovascolare. L’aumento plasmatico della LP(a) può favorire la comparsa di cardiopatia ischemica, di stenosi aortica e dello stroke. La riduzione dei livelli di LP(a) si può ottenere mediante l’utilizzo dell’anticorpo monoclonale (PCSK9i), dell’oligonucleotide antisense e del tutto recentemente mediante l’inclisiran. Le statine non hanno mostrato alcun effetto riduttivo sulla LP(a), anzi il loro utilizzo sembra possa incrementarne i valori.
Imaging cardiologico e radiazioni ionizzanti nel 2022
Authors: Gimelli Alessia , Cademartiri Filippo
Published: March 2022

Le tecniche di imaging invasivo e non invasivo stanno assumendo un ruolo sempre più importante nella valutazione diagnostica e prognostica delle malattie cardiovascolari. La crescente consapevolezza dell’uso e dei possibili effetti collaterali da radiazioni ionizzanti, sia sui pazienti che sugli operatori, ha stimolato l’introduzione di nuovi protocolli e lo sviluppo di nuove tecnologie per ridurre la quantità di dose erogata, mantenendo inalterata la qualità finale dell’esame in oggetto. Scopo di questa review è quello di analizzare da un punto di vista clinico e tecnico le strategie migliori per ottimizzare la strategia diagnostica riducendo al massimo l’esposizione di pazienti ed operatori.
La dignità del morire. L’evoluzione del pensiero
Authors: Larcher Mauro
Published: March 2022

“Meglio la morte” si dice abbia esclamato Luigi XIV°, il Re Sole, ingurgitando l’ennesimo intruglio che i suoi archiatri protomedici gli propinavano, peraltro senza beneficio, per sedare il dolore della gangrena alla gamba che lo avrebbe presto portato alla tomba. Anche se il concetto è un po’ tirato per i capelli, questa esclamazione potrebbe essere considerata una dichiarazione anticipata di trattamento ante litteram.
Aritmie ventricolari minacciose in un paziente COVID non ospedalizzato: potenziale ruolo del monitoraggio remoto del pacemaker
Authors: Campana Andrea , De Pasquale Michele , Perrotti Renato , Ravera Marta , Di Mauro Michele
Published: March 2022

Le aritmie rappresentano una delle principali complicanze dell’infezione da SARS-CoV-2. È stato riportato che i pazienti COVID-19 ospedalizzati che presentano aritmie hanno un maggior numero di comorbidità e frequentemente sviluppano una malattia più grave. Sono molto limitate, al momento, le conoscenze inerenti le aritmie “lifethreatening” in pazienti con COVID-19 non ospedalizzati. Un paziente di 74 anni, obeso, coronaropatico, portatore di pacemaker, diabetico ed iperteso, si ammalò di COVID nel gennaio 2021. I Sanitari preposti lo assegnarono al trattamento domiciliare con antibiotici, cortisone, eparina sottocute ed ossigeno-terapia. Alcuni esami diagnostici strumentali furono eseguiti dopo la ripetuta negativizzazione del tampone molecolare. La tomografia computerizzata ad alta risoluzione del torace rivelò il quadro di una recente polmonite e l’ecocardiogramma mise in luce verosimili esiti di una pericardite. L’interrogazione del pacemaker evidenziò, inaspettatamente, un sorprendente numero di aritmie ventricolari potenzialmente fatali, tre le quali tachicardie ventricolari sostenute e non sostenute, occorse durante la fase acuta e subacuta della malattia. Considerata la buona funzione contrattile del ventricolo sinistro e la causa transitoria delle aritmie, completamente regredite nei ripetuti follow-up successivi, non si ritenne di procedere ad “upgrade” ad ICD ed il paziente fu indirizzato al monitoraggio remoto (MR). Aritmie minacciose possono verificarsi nei pazienti COVID trattati a domicilio, particolarmente in quelli con comorbidità; nei portatori di pacemaker affetti da infezione da SARS-CoV-2, l’uso del MR può giocare un ruolo decisivo nella diagnosi precoce delle aritmie.
Node Propagation of Switchgrass v1
Authors: Brennan Darlene , Lowry David
Published: March 2022

This protocol can be used to clonally propagate switchgrass under sterile conditions in six weeks. It describes how to prepare and propagate the nodes on an MS-based media. These shoots are ideal for experiments that would require pest and pathogen-free switchgrass clones, such as microbiome studies.
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Authors: XS Keto Ketosium
Published: March 2022

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Crystallization, data collection and structure solution of PxP-VAB v1
Authors: not provided jyoti.adlakha
Published: March 2022

Protocol lists the steps to obtain PxP(Mcp1ct)-VABct crystals, X-ray diffraction data acquisition and obtaining the structure solution using molecular replacement with a model generated by AlphaFold2.
[RETRACTED] Ketosium XS Keto Reviews – Must Read Complaints and Warnings | Real Ketogenic Formula or Scam? v1
Authors: XS Keto Ketosium
Published: March 2022

[RETRACTED]

Ketosium XS Keto Reviews : Supplements May Be Risky! Quality Ingredients That Work?
[RETRACTED] KetoSlim Supreme Gummies Reviews : Shocking Price & Customer Feedbacks and Shocking Side effects v1
Authors: not provided ketoslimgummies
Published: March 2022

[RETRACTED]

KetoSlim Supreme Gummies is a weight-loss supplement that is both sophisticated and medically approved. The technique aids customers in losing weight and attaining their desired physique in real-time.
Transnational Social Protection: Inclusion for Whom? Theoretical Reflections and Migrant Experiences
Authors: Scheibelhofer Elisabeth
Published: March 2022

With migration being a reality within and between nation‐states worldwide, transnational social protection has become a concern on various levels. This thematic issue focuses on nation‐state conceptions and policies, migrants’ experiences with regards to accessing social protection, as well as the social inequalities resulting from the nexus of transnational social protection and migration.
The Effects of the Assimilation and Use of IT Applications on Financial Performance in Healthcare Organizations
Authors: Setia Pankaj ,   University of Arkansas, Setia Monika ,   Duke-NUS Graduate Medical School, Krishnan Ranjani ,   Michigan State University, Sambamurthy Vallabh ,   Michigan State University
Published: March 2022

This research examines the impacts of the assimilation and use of IT on the financial performance of hospitals. We identify two dimensions of IT assimilation and use. They are the IT applications architecture spread, which is the adoption of a broad array of IT solutions, and IT applications architecture longevity, which is the length of experience with use of specific IT solutions. We examine the extent to which these dimensions of assimilation within the business and clinical work processes impact hospital performance. Compared with the effects of IT applications architecture spread, we find that the IT applications architecture longevity has a more significant effect on financial performance. In addition, the effects of assimilation manifest differently across the business and clinical process domains. Our results enhance understanding about the manner in which the assimilation and use of IT contributes to the financial performance of hospitals.
Comparative evaluation of combined and isolated applications of high-intensity focused ultrasound and super-selective uterine artery embolization in treatment of patients with uterine fibroids
Authors: Politova Alla K. , Kira Evgeny F. , Bolomatov Nikolay V. , Kitayev Vycheslav   M. , Bruslik Sergey V. , Sviridova Tatyana I. , Slabozhankina Ekaterina A. , Amelina Yulia L. , Politova Alexandra A.
Published: March 2022

BACKGROUND: Uterine fibroids are a benign tumor found in two out of three women of reproductive age. The most modern methods of organ preserving treatment of uterine fibroids are uterine artery embolization, which is a minimally invasive procedure, and high intensity focused ultrasound (HIFU) ablation, which is a non-invasive procedure. According to the literature and our own experience, uterine artery embolization is ineffective in 17.1% of cases and HIFU ablation in 16% of cases, mainly due to the peculiarities of blood supply to myomatous nodes.
AIM: The aim of this study was to compare the effectiveness of the treatment of uterine fibroids using an isolated HIFU ablation technique and combined sequential application of selective embolization of uterine artery supplying the myomatous node and HIFU ablation.
MATERIALS AND METHODS: This study included two groups of patients with symptomatic uterine fibroids. Group 1 consisted of 133 patients treated using the isolated HIFU ablation, and group 2 comprised 90 patients treated sequentially using supplying the myomatous node and HIFU ablation. Age and clinical manifestations of the disease (menometrorrhagia, pain syndrome, impaired function of adjacent organs, anemia) did not differ in the both groups.
RESULTS: The following parameters were different in the study groups: the duration of ultrasound ablation (p 0.005) and the decrease in the volume of myomatous nodes in one, six and 12 months after surgery (p 0.001). The duration of ultrasound ablation was 610.84 (56.26) minutes in group 1 and 215.28 (70.57) minutes in group 2. In group 1, the decrease in the volume of myomatous nodes was 12.2% in one month and 58.97% in 12 months after surgery, compared to the initial value. In group 2, the decrease was 42.9% and 67.5%, respectively.
CONCLUSIONS: The combined treatment of uterine fibroids using supplying the myomatous node and FUVI ablation techniques allowed for reducing the duration of the FUVI ablation operation three times and the volume of the node by 67.5% within one year compared to group 1 (58.97%).
Technology for early differential diagnosis of hypertensive disorders during pregnancy
Authors: Mudrov Victor A. , Mudrov Andrey A.
Published: March 2022

BACKGROUND: To date, no test provides sufficient sensitivity and specificity for the early diagnosis of severe preeclampsia. Meanwhile, severe preeclampsia is a condition that threatens the life of not only the mother, but also the fetus, and requires a solution to the issue of delivery. Therefore, the search for markers of severe preeclampsia is still relevant today.
AIM: The aim of this study was to create a technology that allows for early differential diagnosis of hypertensive disorders during pregnancy based on a comprehensive analysis of echocardiographic data.
MATERIALS AND METHODS: Based on the data collected in the Regional Clinical Hospital Perinatal Center, Chita, Russia in 2018-2021, the retrospective analysis of 112 cases of labor was carried out. The total sample was divided into five study groups: 30 relatively healthy women (group 1); 25 patients with chronic arterial hypertension (group 2); 21 patients with gestational arterial hypertension (group 3); 13 patients with moderate preeclampsia (group 4); and 23 patients with severe preeclampsia (group 5). The groups were formed in accordance with current clinical guidelines. Echocardiographic examination in all cases was carried out upon admission to the hospital. Statistical processing of the results was performed using the IBM SPSS Statistics Version 25.0 program.
RESULTS: The technology for early differential diagnosis of hypertensive disorders during pregnancy is implemented based on a multilayer perceptron, the percentage of incorrect predictions being 20.5 %. The structure of the trained neural network included six input neurons: gestational age, left atrium size in the parasternal position, right ventricular size, interventricular septal thickness, systolic blood flow velocity, and pressure gradient in the pulmonary artery.
CONCLUSIONS: Comprehensive analysis of echocardiographic data allows for early differential diagnosis of hypertensive disorders during pregnancy, while considering the result of neural network analysis as an additional criterion for severe preeclampsia. In the future, the use of this technology in clinical practice will not only optimize the tactics of managing patients with hypertensive disorders at admission to the hospital, but also reduce the incidence of adverse obstetric and perinatal outcomes.
Comprehensive molecular and morphological study of abortion material in missed abortion of the first trimester
Authors: Romanova Olga A. , Pechenikova Victoria A.
Published: March 2022

BACKGROUND: Missed abortion is the main cause of reproductive loss in the first trimester, and genetic causes come first in the etiology of this disease. The immunological aspects of the mother-fetus system are currently widely discussed. In this regard, the study of the immunological relationship between the mothers body and the fetus in missed abortion, depending on the chorion karyotype, as well as after suffering reproductive loss, is a topical task, as it can optimize the methods of examining patients with missed abortion and identify factors that contribute to the development of recurrent miscarriage.
AIM: The aim of this study was to investigate the morphological and immunohistochemical characteristics of abortion material in missed abortion, depending on the presence of chorionic chromosomal abnormalities and the patients history of reproductive losses.
MATERIALS AND METHODS: We performed a comprehensive morphological and immunohistochemical study (CD56, HLA-DR-II) of abortion material in 273 cases of missed abortion. Group 1 consisted of patients with different variants of chorionic chromosomal abnormalities (n = 169); group 2 included subjects with a normal karyotype of the chorion (n = 104). The data analysis was carried out taking into account the anamnesis of patients, depending on the presence of reproductive losses.
RESULTS: We revealed the morphological features of the abortion material in missed abortion in cases with chromosomal abnormalities of the chorion: pronounced edema, sclerosis, necrosis of chorionic villi, more pronounced inflammatory changes in the form of moderate and severe macrophage infiltration of the decidual tissue and endometrium, and accumulations of leukocytes as microabscesses. It has been proven that the severity of inflammatory changes in abortuses depends only on the chorion karyotype and does not depend on either the duration of the presence of an unviable fetal egg in the uterine cavity, or the patients history of reproductive losses. It was shown that the CD56 and HLA-DR-II expressions in the abortion material depend on the patients history of reproductive losses, regardless of the chorion karyotype.
CONCLUSIONS: In patients with an unburdened obstetric and gynecological history in the first missed abortion, it is advisable only to determine the chorion karyotype in order to identify the cause of missed abortion. The immunohistochemical study of the abortion material with the determination of the CD56 and HLA-DR-II expressions is important in repeated missed abortions, regardless of the chorion karyotype.
Change.org как форма “случайной политики”: анализ русскоязычных петиций
Authors: Иваненко Елена
Published: March 2022

Исследование представляет собой эмпирический анализ петиций на Change.org как характерного инструмента цифрового гражданского активизма. Данные собраны за весь период существования платформы в России с 2012 г. по 2020 г. включительно; всего обработано 27 259 петиций на русском языке. В качестве теоретической оптики в статье предлагается использовать концептуальный аппарат философской антропологии жертвы и рассмотреть специфику работы Change.org как способ взаимодействия граждан с виктимизированными объектами социальной действительности, включив таким образом действие цифровых петиций в пространство экономики жертвы. Обнаруженное сходство между виктимогенными категориями культурной виктимологии и ключевыми темами петиций Change.org позволяет утверждать, что цифровые петиции маркируют зоны, восприимчивые к конструкту жертвы, понятому предельно широко как социальная асимметрия, построенная на уязвимости и требующая децентрализованного коллективного решения о справедливости/несправедливости. Децентрализованная горизонтальная структура цифрового активизма проблематизируется через понятия “случайные политики” и “слактивизм”, а сопутствующий тип гражданской ответственности определяется с помощью концепта “театр солидарности”. Проведенная работа с базой данных позволила определить петиции, сопровождаемые общественным резонансом, собрать их характеристики и получить общую картину динамики цифрового гражданского активизма в России по годам. В целом исследование вносит вклад в тематизацию нового знания в двух областях: в области теории политического цифрового участия и в области философской антропологии жертвы.