bluuebunny/crossref_metadata_2025 huggingface dataset:
Automatic detection of cataclysmic variables from SDSS images
Authors: Huang Junfeng , Qu Meixia , Jiang Bin , Zhang Yanxia
Published: June 2023

Investigating rare and new objects have always been an important direction in astronomy. Cataclysmic variables (CVs) are ideal and natural celestial bodies for studying the accretion process of semi-detached binaries with accretion processes. However, the sample size of CVs must increase because a lager gap exists between the observational and the theoretical expanding CVs. Astronomy has entered the big data era and can provide massive images containing CV candidates. CVs as a type of faint celestial objects, are highly challenging to be identified directly from images using automatic manners. Deep learning has rapidly developed in intelligent image processing and has been widely applied in some astronomical fields with excellent detection results. YOLOX, as the latest YOLO framework, is advantageous in detecting small and dark targets. This work proposes an improved YOLOX-based framework according to the characteristics of CVs and Sloan Digital Sky Survey (SDSS) photometric images to train and verify the model to realise CV detection. We use the Convolutional Block Attention Module to increase the number of output features with the feature extraction network and adjust the feature fusion network to obtain fused features. Accordingly, the loss function is modified. Experimental results demonstrate that the improved model produces satisfactory results, with average accuracy (mean averagePrecisionat 0.5) of 92.0%,Precisionof 92.9%,Recallof 94.3%, and$F1-score$of 93.6% on the test set. The proposed method can efficiently achieve the identification of CVs in test samples and search for CV candidates in unlabeled images. The image data vastly outnumber the spectra in the SDSS-released data. With supplementary follow-up observations or spectra, the proposed model can help astronomers in seeking and detecting CVs in a new manner to ensure that a more extensive CV catalog can be built. The proposed model may also be applied to the detection of other kinds of celestial objects.
Patterns of Affective Polarization toward Parties and Leaders across the Democratic World
Authors: REILJAN ANDRES , GARZIA DIEGO , FERREIRA DA SILVA FREDERICO , TRECHSEL ALEXANDER H.
Published: June 2023

Research indicates that affective polarization pervades contemporary democracies worldwide. Although some studies identify party leaders as polarizing agents, affective polarization has been predominantly conceptualized as a product of in-/out-party feelings. This study compares levels of party affective polarization (PAP) and leader affective polarization (LAP) cross-nationally, using data from the Comparative Study of Electoral Systems. Applying like–dislike scales and an identical index to both concepts, we reveal that while the two strongly correlate, LAP is systematically lower than PAP. The United States emerges as an exceptional case, being the only country where LAP significantly exceeds PAP. Drawing on regime input/output and institutions as theoretical building blocks, we explore cross-national variations and show that the relative strength of LAP vis-à-vis PAP is increased by presidential regime type, poor government performance, and low party system fragmentation. The findings of this study contribute to the thriving research on affective polarization and personalization of politics.
Affirmative Action, Paternalism, and Respect
Authors: Bengtson Andreas , Møller Lyngby Pedersen Viki
Published: June 2023

This article investigates the hitherto under-examined relations between affirmative action, paternalism, and respect. We provide three main arguments. First, we argue that affirmative action initiatives are typically paternalistic and thus disrespectful towards intended beneficiaries who oppose them. Second, we argue that not introducing affirmative action can be disrespectful towards these potential beneficiaries because such inaction involves a failure to recognize their moral worth adequately. Third, we argue that the paternalistic disrespect involved in affirmative action is alleviated when the potential beneficiaries' preferences against such initiatives are adaptive. We conclude that, although there is a relevant sense in which paternalistic affirmative action is disrespectful, it may be more disrespectful not to pursue such policies.
The Owl and the Occult: Popular Politics and Social Liminality in Early Modern South Asia
Authors: Cherian Divya
Published: June 2023

Historians of Islamic occult science and post-Mongol Persianate kingship in the Ottoman, Safavid, and Mughal Empires have in recent years made clear just how central this body of knowledge was to the exercise of imperial power. Alongside, scholarship on tantra has pointed to its diffuse persistence in the early modern period. But what dynamics beyond courts and elite initiates did these investments in occult science and tantra unleash? Through a focus on the seventeenth-century Mughal court and the Rajput polity of Marwar in the eighteenth century, this article weaves together the history of animals with that of harmful magic by non-courtly actors. It demonstrates the blended histories of tantra, Islamicate occult sciences, and folk magic to argue that attributions of liminality encoded people, animals, and things with occult potential. For some, like the owl, this liminality could invite violence and death and for others, like expert male practitioners, it could generate authority. By the eighteenth century, the deployment of practical magic towards harmful or disruptive ends was a political tool wielded not only by kings and elite adepts for state or lineage formation but also by non-courtly subjects and “low”-caste specialists in local social life. States and sovereigns responded to the popular use of harmful magic harshly, aiming to cut off non-courtly access to this resource. If the early modern age was one of new ideologies of universal empire, the deployment of occult power outside the court was inconsistent with the ambitions of the kings of this time.
Biofortification of maize growth, productivity and quality using nano-silver, silicon and zinc particles with different irrigation intervals
Authors: Kandil Essam E. , Lamlom Sobhi F. , Gheith El-Sayed M.S. , Javed Talha , Ghareeb Rehab Y. , Abdelsalam Nader R. , Hussain Sadam
Published: June 2023

The current study aimed to investigate biofortification of maize grown under different irrigation intervals, i.e. 15, 20 and 25 days (hereinafter referred to as IR15, IR20 and IR25, respectively), using foliar application treatments (silicon (Si), zinc (Zn), silver nanoparticles (AgNPs), Si + Zn, Si + AgNPs, Zn + AgNPs and Si + Zn + AgNPs) in two growing seasons, 2020 and 2021. A split-plot design with four replications was used, where irrigation intervals and foliar treatments were assigned in main plots and subplots, respectively. IR15 received a total of 7925 m3/ha irrigation water divided over seven irrigations, while IR20 received 5690 m3/ha divided over five irrigations and IR25 received 4564 m3/ha divided over four irrigations. The highest yield and grain quality were observed in plants irrigated at 15-day intervals. Spraying the canopy with Si, Zn and AgNPs, either individually or in combination, reduced the negative impact of water stress caused by longer irrigation intervals on plant growth, yield, yield components and grain protein content. In IR15 + AgNPs + Zn, most of the studied parameters, except for proline content, showed a high positive impact, especially on 100-kernel weight (KW). In contrast, IR25 + Si + AgNPs + Zn showed the highest positive effects on proline and protein contents but a negative impact on the harvest index. Collectively, IR15 + Si + AgNPs + Zn resulted in the highest values of all studied parameters, followed by IR15 + Si + AgNPs and IR15 + Si + Zn. In conclusion, our results suggest that an irrigation interval of 15 days combined with application of Si, Zn and AgNPs has the potential to improve yield and quality of maize under water deficit stress.
The Latin American Bullring: US Evangelicals and the Reception of Anti-Protestant Violence from Cold War Colombia
Authors: KIRKPATRICK DAVID C.
Published: June 2023

In the shadow of the Cuban Revolution, American Baptist preacher Billy Graham and US President John F. Kennedy barnstormed South America through overlapping tours in 1961 and 1962. Kennedy's presidency has often been presented as an intermission in the drama of evangelical political power, but grassroots activism provides new angles for analysis at the intersection of the US and Latin America. While claiming an apolitical stance, Graham worked alongside the US State Department, planting spiritual seeds on the tilled ground of foreign policy. Graham – and Protestant leaders orbiting him – curated acts of violence, painting a picture of persecution for a watching public. This narrative employed violence to draw lines of worldwide spiritual affiliation and political obligation. US evangelicals placed themselves as custodians of America's most sacred values at home and abroad, responsible for upholding democratic values, including religious tolerance, the rule of law, and anticommunism. Graham's tactics created an entangled relationship with Kennedy, where Graham arose as a metaphorical matador, fighting for persecuted Christians. Here, American evangelicals could flex their growing political muscle, while operating as an imagined religious minority community. Narratives, discourses, and representations of violence circulated transnationally and acquired differing meanings depending on the political interests of those mobilizing them.
Gender and Managerial Job Mobility: Career Prospects for Executives Displaced by Acquisitions
Authors: Guo Xiaohu , Gupta Vishal K. , Mortal Sandra , Nanda Vikram
Published: June 2023

We investigate how men and women fare in the managerial labor market in the plausibly exogenous circumstance of their firms being acquired when most target-firm managers (about 90%) are displaced. These career disruptions result in a larger drop in rank and compensation for female managers, despite similar job search attributes. Gender differences are mitigated when hiring firms have more women in upper-echelon positions. Rich managerial experience and external board service also reduce gender-related differences. Overall, results point to a (implicit) “gender penalty” in terms of managerial job mobility, but also indicate contexts in which penalty is alleviated, and even reversed.
Credit Default Swaps, Fire-Sale Risk, and the Liquidity Provision in the Bond Market
Authors: Massa Massimo , Zhang Lei
Published: June 2023

We study the effect of credit default swaps (CDSs) on the bond market. Using a comprehensive sample of U.S. corporate bonds, we document that the presence of CDSs significantly increases bond liquidity and reduces yield spreads for investment grade bonds. We show that CDSs influence the bond market by lowering the impact of fire sales of institutional bondholders and facilitating inventory management for bond dealers who absorb fire sale shocks. However, the liquidity provision role of CDSs gets weakened after the CDS Big Bang in 2009, potentially because of the requirement of large upfront payments.
A longitudinal comparison of emotional, behavioral and attention problems in autistic and typically developing children
Authors: Wright N. , Courchesne V. , Pickles A. , Bedford R. , Duku E. , Kerns C. M. , Bennett T. , Georgiades S. , Hill J. , Richard A. , Sharp H. , Smith I. M. , Vaillancourt T. , Zaidman-Zait A. , Zwaigenbaum L. , Szatmari P. , Elsabbagh M. ,   Pathways Team
Published: June 2023

Background

Mental health problems are elevated in autistic individuals but there is limited evidence on the developmental course of problems across childhood. We compare the level and growth of anxious-depressed, behavioral and attention problems in an autistic and typically developing (TD) cohort.

Methods

Latent growth curve models were applied to repeated parent-report Child Behavior Checklist data from age 2–10 years in an inception cohort of autistic children (Pathways, N = 397; 84% boys) and a general population TD cohort (Wirral Child Health and Development Study; WCHADS; N = 884, 49% boys). Percentile plots were generated to quantify the differences between autistic and TD children.

Results

Autistic children showed elevated levels of mental health problems, but this was substantially reduced by accounting for IQ and sex differences between the autistic and TD samples. There was small differences in growth patterns; anxious-depressed problems were particularly elevated at preschool and attention problems at late childhood. Higher family income predicted lower base-level on all three dimensions, but steeper increase of anxious-depressed problems. Higher IQ predicted lower level of attention problems and faster decline over childhood. Female sex predicted higher level of anxious-depressed and faster decline in behavioral problems. Social-affect autism symptom severity predicted elevated level of attention problems. Autistic girls' problems were particularly elevated relative to their same-sex non-autistic peers.

Conclusions

Autistic children, and especially girls, show elevated mental health problems compared to TD children and there are some differences in predictors. Assessment of mental health should be integrated into clinical practice for autistic children.
Engaging and developing Ada Agada's philosophy: moral responsibility, creation, and the problem of evil
Authors: Cordeiro-Rodrigues Luis
Published: June 2023

In a recent article in Religious Studies, Ada Agada argues that the problem of evil is relevant not only to those who consider God to hold the Omni-properties but also to those who understand God as a limited deity. He rightly points out that the limited-God literature in the African philosophy of religion has neglected to address the problem of evil by too quickly dismissing it. Agada then argues that the reason why the problem of evil is philosophically relevant for the limited-God view is that He, as the creator, has sufficient powers to address evil and, thereby, moral responsibility regarding the evil in the world. In this reply, I uphold that although Agada is correct to affirm that the problem of evil is relevant for the limited-God view, he is mistaken to contend that the reason is that God is the creator. I contest this view and argue that Agada has not given enough reasons to believe that God has moral responsibility over evil in the world. However, I illuminate how Agada can develop this argument in the future.
Modal-epistemic arguments for the existence of God based on the possibility of the omniscience and/or refutation of the strong agnosticism
Authors: Bertato Fábio Maia
Published: June 2023

In this article I present some modal-epistemic arguments for the existence of God, based on the possibility of omniscience. For this, I provide modal formal systems that allow obtaining the existence of God as a theorem. Moreover, based on what I assume as reasonable premises, they show that the strong agnostic position is contradictory, since it allows the conclusion both that God exists and that God does not exist.
How much horrific suffering is enough?
Authors: Frances Bryan
Published: June 2023

Isn't there something like an amount and density of horrific suffering whose discovery would make it irrational to think God exists? Use your imagination to think of worlds that are much, much, much worse than you think Earth is when it comes to horrific suffering. Isn't there some conceivable scenario which, if you were in it, would make you say ‘Okay, okay. God doesn't exist, at least in the way we thought God was. We were wrong about that’? Pursuing this question leads to what I call the Problem of Absurd Evil.
The pragmatics of standardization: document standards and their implementation in Qin administration (late third century bce)
Authors: Staack Thies
Published: June 2023

With a view to the necessities as well as the possible problems of a document-based administration, this paper approaches the area of conflict between standardization and flexibility in the production of administrative documents in ancient China. Recently published sources from the imperial Qin period (221–207 bce) have provided the opportunity to compare administrative documents excavated at Liye with standards regulating their production. With the help of two case studies, the paper explores to what extent official document standards were implemented in everyday practice or purposefully neglected in ancient Qianling county. It also discusses which standards were followed more closely than others, and what might be the reasons behind this. Shedding light on the large grey zone between faithful adherence and complete neglect, the paper suggests that officials chose a pragmatic way influenced by both economic considerations informed by the local circumstances and the requirements imposed by the central government.
Burden of care and quality of life among informal caregivers to Alzheimer patients in Egypt
Authors: Ibrahim Ateya Megahed , Ibrahim Mahmoud Metwally , Zaghamir Donia Elsaid Fathi
Published: June 2023

Background

Alzheimer’s disease is a chronic neurodegenerative disorder that results in total cognitive impairment and functional decline. Family members are the most usual caregivers worldwide, resulting in an increasing total burden and a subsequent degradation of their quality of life.

Objectives

To evaluate the burden of care and quality of life among informal caregivers to Alzheimer patients in Egypt.

Methods

A descriptive research design was used. The study was conducted at outpatient clinics of El-Abbasya Mental Hospital in Cairo, Egypt. This study included 550 informal caregivers of Alzheimer patients. Data were gathered through questionnaires using the Sociodemographic Profile of Family Caregivers, an adopted version of the Montgomery Borgatta Caregiver Burden scale, and Health-Related Quality of Life Scale.

Results

Nearly three quarters (73.5%) of the informal caregivers were female. Additionally, the physical burden among the informal caregivers was the highest (21.58 ± 8.13), while the psychological burden was the lowest (7.48 ± 25.35). Besides, around one-third (30%) of the informal caregivers had a total poor quality of life.

Significance of results

Total burden among informal caregivers of Alzheimer patients was relatively high (64.71 ± 26.86). Moreover, less than one-tenth (8%) of the informal caregivers for Alzheimer’s patients had a good quality of life, whereas more than half (62%) of them had an average quality of life. In the Egyptian context, ongoing health education initiatives for those who care for Alzheimer patients are essential, and additional research employing large study sample sizes in varied contexts is strongly advised.
Exchanges with and without the sword: slavery, politics-as-exchange and freedom in James M. Buchanan's institutional economics
Authors: Meadowcroft John
Published: June 2023

James M. Buchanan's politics-as-exchange retrospectively conceptualized formal institutions emerging from bilateral agreements to establish reciprocal rights and prospectively guided constitutional entrepreneurs to broker Pareto-superior reforms that had unanimous consent. Buchanan believed this conceptualization of politics-as-exchange was necessitated by his ontological–methodological individualism and would initiate a new era of consensual politics, but it is argued it led to illiberal conclusions that reflected dissonance between his Kantian individualism and Humean subjectivism. It meant, for example, that slavery was characterized as a bilateral agreement between very unequal parties and it is argued it logically implied abolition required the consent of slaveowners. But Buchanan's ontology was compatible with the introduction into his framework of a right of exit that would have differentiated between exchanges with and without the sword to produce a consistent liberal constitutionalism.
Prominence over proximity? Terror attacks’ impact on party preferences
Authors: Hoes Emma , Kamphorst Jonne , Krouwel André
Published: June 2023

How does a terrorist attack affect party preferences? Based on existing theories, we would either expect incumbent parties to benefit because of a rally-effect, or populist radical right parties (PRRPs) to gain due to a radicalization of voters’ preferences. These competing theories are tested with a unique dataset of a large sample of voters’ responses on a Voting Advice Application. We do so using a novel way to leverage exogenous events using big public opinion data. We show that a terrorist attack has a positive effect for the main incumbent party, even when voters’ positions on the issues owned by the PRRPs become more radicalized. This means that during crises, voters rally around the flag and prefer prominence over policy proximity.
Adaptive triple-fed antenna and thinned RF-chip integration into ultra thin flexible polymer foil
Authors: Fischer-Kennedy Serafin B. , Özbek Sefa , Wang Shuo , Grözing Markus , Hesselbarth Jan , Berroth Manfred , Burghartz Joachim N.
Published: June 2023

Attaching a wireless transmission system comprising a radio frequency (RF)-chip and a dipole antenna to dielectric material of largely different permittivity leads to strong variation of the antenna feed impedance. Due to the severe impedance mismatch between the RF-chip and the antenna, the performance of the system may deteriorate drastically. The proposed antenna provides three feed points, which show respective feed-point match to 100 Ohm balanced feeds for three different dielectric environments (free-space and half-spaces of permittivity 4 and 42, respectively). Thereby, the RF-chip incorporates three 100 Ohm balanced output ports that are connected to the antenna from whom only one can be selected to provide the output signal. The respective other two output ports are shorted by an internal switching circuit that is controlled by external DC voltages. The measurement of the reflection coefficient of the stand-alone antenna and the chip agree well with the simulations, allowing to interconnect these two components. Further, the radiation pattern of the whole system is measured for two different scenarios showing good functionalities.
Face, Construct and Criterion Validity, and Test-Retest Reliability, of the Adult Rejection Sensitivity Questionnaire
Authors: Mishra Mandira , Allen Mark S.
Published: June 2023

Abstract: This research sought to test the face, construct and criterion validity, and test-retest reliability of the Adult Rejection Sensitivity Questionnaire (ARSQ). In Study 1, participants ( n = 45) completed the ARSQ and questions assessing scale item relevancy, clarity, difficulty, and sensitivity. In Study 2, participants ( n = 513) completed the ARSQ and demographic questions. In Study 3, participants ( n = 244) completed the ARSQ and returned 2 weeks later to complete the ARSQ and measures of depression, anxiety, and self-silencing behavior. Study 1 provided strong support for face validity with all items deemed relevant, clear, easy to answer, and neither distressing nor judgmental. Study 2 provided adequate support for the factor structure of the ARSQ (single-factor model and two-factor model) but suggested modifications could be made to improve scale validity. Study 3 provided further support for an adequate (but not good) factor structure, and evidence for criterion validity established through medium-large effect size correlations with depression, anxiety, and self-silencing behavior. However, the 2-week scale stability appeared poor ( r = .45) in a subsample of participants. Overall, the ARSQ showed sufficient validity to recommend its continued use, but we recommend further tests of scale reliability and potential modifications to increase construct validity.
Hyporheic Oxygen Dynamics in the East River, Colorado: Insights From an In‐Situ, High Frequency Time Series During Two Distinct Flow Seasons
Authors: Gooseff Michael N. , Ghosh Ruby N. , Cantrell Erin , Matusz M. Evan , McIntire Charles , Philip Vivek
Published: June 2023

Dissolved oxygen (DO) is critical for aquatic ecosystems, however, few studies have focused on the long‐term DO dynamics in hyporheic zones, which are a function of both transport (hydrologic exchange between river and hyporheic zone) and uptake by biogeochemical reactions or respiration. We explore the dynamics of temperature and DO at 10, 20, and 35 cm depth beneath the East River, Colorado, from July–October 2017 (relatively normal water year) and April to October 2018 (comparatively low flow year), enabled by distinctive, in‐situ, high frequency (Δt = 5 min) sensors that provided continuous time‐series from the undisturbed study site over 14 months. We expect that hyporheic DO, which has a regular daily fluctuation pattern, is supplied by the surface water (at all times we estimate downwelling) and that diurnal hyporheic DO temporal patterns should be aligned with diurnal hyporheic temperature patterns. However, this was not found to be the case. Hyporheic DO becomes depleted briefly at 20 and 35 cm depths in 2017, and at all three hyporheic depths for extended periods in 2018. Whereas diurnal temperature fluctuations have consistent timings of maxima and minima, hyporheic DO rarely has as regular a pattern, and daily ranges are inconsistent. Rainfall events caused some of these changes to diurnal hyporheic DO patterns without repeatable effects. Antecedent snowpack conditions influence streamflow dynamics and therefore hyporheic DO dynamics in this alpine river. These results also point to the strong and variable influence of hyporheic microbial communities regulating hyporheic DO.
Modulation of the Central Pacific El Niño on the Relationship Between the Hadley Circulation and Tropical SST
Authors: Hong Qin , Feng Juan , Li Jianping
Published: June 2023

Based on observational data, the effects of Central Pacific (CP) El Niño events on the relationship between the Hadley circulation (HC) and tropical sea surface temperature (SST) under different meridional structures are investigated. The variability of HC and SST have been decomposed into equatorially symmetric and asymmetric components to detect their relationship. The explained variances of the equatorially asymmetric and symmetric components of the HC's principal modes both decreased in the CP El Niño events. Compared to climatology, the responses of HC to SST under different meridional structures are suppressed during CP El Niño events. It has been discovered that SST variations in the tropical eastern Pacific (EP) are responsible for the different response of HC to tropical SST. The EP SST anomalies exhibit inhomogeneous variations during CP El Niño events, with a greater amplitude in the north EP, resulting in enhanced variation of the equatorially asymmetric SST. The modulation of the CP El Niño on the relationship between the HC and tropical SST provides evidence for its complex climate effects.
Early Holocene Laurentide Ice Sheet Retreat Influenced Summer Atmospheric Circulation in Baffin Bay
Authors: Thomas Elizabeth K. , Cluett Allison A. , Erb Michael P. , McKay Nicholas P. , Briner Jason P. , Castañeda Isla S. , Corcoran Megan C. , Cowling Owen C. , Gorbey Devon B. , Lindberg Kurt R. , Prince Karlee K. , Salacup Jeffrey
Published: June 2023

Changes in ice‐sheet size impact atmospheric circulation, a phenomenon documented by models but constrained by few paleoclimate records. We present sub‐centennial‐scale records of summer temperature and summer precipitation hydrogen isotope ratios (δ2H) spanning 12–7 ka from a lake on Baffin Island. In a transient model simulation, winds in this region were controlled by the relative strength of the high‐pressure systems and associated anticyclonic circulation over the retreating Greenland and Laurentide ice sheets. The correlation between summer temperature and precipitation δ2H proxy records changed from negative to positive at 9.8 ka. This correlation structure indicates a shift from alternating local and remote moisture, governed by the two ice‐sheet high‐pressure systems, to only remote moisture after 9.8 ka, governed by the strong Greenland high‐pressure system after the Laurentide Ice Sheet retreated. Such rapid atmospheric circulation changes may also occur in response to future, gradual ice‐sheet retreat.
PCSSR‐DNNWA: A Physical Constraints Based Surface Snowfall Rate Retrieval Algorithm Using Deep Neural Networks With Attention Module
Authors: Yan Songkun , Ma Ziqiang , Li Xiaoqing , Hu Hao , Xu Jintao , Ji Qingwen , Weng Fuzhong
Published: June 2023

Global surface snowfall rate estimation is crucial for hydrological and meteorological applications but is still a challenging task. A novel approach is developed to comprehensively use passive microwave, infrared data and physical constraints in deep‐learning neural networks with an attention module for retrieving surface snowfall rate (PCSSR‐DNNWA). The PCSSR‐DNNWA consistently outperforms traditional approaches in predicting surface snowfall rates with a correlation coefficient of ∼0.76, mean error of ∼−0.02 mm/hr, and root mean squared error of ∼0.21 mm/hr. It is found that graupel water path is of vital importance with largest contributions in retrieving surface snowfall rate. By integrating the physical constraints, the algorithm of PCSSR‐DNNWA opens a new avenue for retrieving the surface snowfall rate from satellites since some predictors are intelligently considered, resulting in an increased accuracy, interpretability, and computational efficiency.
Waves in Magnetosheath Jets—Classification and the Search for Generation Mechanisms Using MMS Burst Mode Data
Authors: Krämer E. , Hamrin M. , Gunell H. , Karlsson T. , Steinvall K. , Goncharov O. , André Mats
Published: June 2023

Magnetosheath jets are localized dynamic pressure enhancements in the magnetosheath. We make use of the high time resolution burst mode data of the Magnetospheric Multiscale mission for an analysis of waves in plasmas associated with three magnetosheath jets. We find both electromagnetic and electrostatic waves over the frequency range from 0 to 4 kHz that can be probed by the instruments on board the MMS spacecraft. At high frequencies we find electrostatic solitary waves, electron acoustic waves, and whistler waves. Electron acoustic waves and whistler waves show the typical properties expected from theory assuming approximations of a homogeneous plasma and linearity. In addition, 0.2 Hz waves in the magnetic field, 1 Hz electromagnetic waves, and lower hybrid waves are observed. For these waves the approximation of a homogeneous plasma does not hold anymore and the observed waves show properties from several different basic wave modes. In addition, we investigate how the various types of waves are generated. We show evidence that, the 1 Hz waves are connected to gradients in the density and magnetic field. The whistler waves are generated by a butterfly‐shaped pitch‐angle distribution and the electron acoustic waves by a cold electron population. The lower hybrid waves are probably generated by currents at the boundary of the jets. As for the other waves we can only speculate about the generation mechanism due to limitations of the instruments. Studying waves in jets will help to address the microphysics in jets which can help to understand the evolution of jets better.
Remote Sensing of Riverbank Migration Using Particle Image Velocimetry
Authors: Chadwick Austin J. , Greenberg Evan , Ganti Vamsi
Published: June 2023

Mobile river channels endanger human life and property and over centuries shape ecosystems, landscapes, and stratigraphy. Quantifying channel movements from remote sensing is difficult, in part due to the diversity of river mobility processes (e.g., channel migration, cutoffs, avulsion) and planform morphologies (e.g., meandering, braided). Here, we present a framework for quantifying riverbank migration from remote sensing that upscales recent methodological advances from laboratory flume studies utilizing particle image velocimetry (PIV). We apply PIV to image time series of 21 rivers worldwide, showing PIV ignores cutoff and avulsion processes by design and is well suited for tracking riverbank migration regardless of planform morphology. We show that PIV‐derived results for riverbank migration are consistent with published results from centerline‐ and bank‐based Lagrangian methods. Unlike existing methods, PIV offers a grid‐based Eulerian framework where defining channel centerlines is unnecessary and quantified uncertainty in riverbank positions is propagated into uncertainty in migration rates. PIV offers means to efficiently extract global patterns in riverbank migration from decades of satellite data, as well as investigate river response to climate change and human activities in our rapidly changing world.
Salivary biomarkers: novel noninvasive tools to diagnose chronic inflammation
Authors: Dongiovanni Paola , Meroni Marica , Casati Sara , Goldoni Riccardo , Thomaz Douglas Vieira , Kehr Nermin Seda , Galimberti Daniela , Del Fabbro Massimo , Tartaglia Gianluca M.
Published: June 2023

Several chronic disorders including type 2 diabetes (T2D), obesity, heart disease and cancer are preceded by a state of chronic low-grade inflammation. Biomarkers for the early assessment of chronic disorders encompass acute phase proteins (APP), cytokines and chemokines, pro-inflammatory enzymes, lipids and oxidative stress mediators. These substances enter saliva through the blood flow and, in some cases, there is a close relation between their salivary and serum concentration. Saliva can be easily collected and stored with non-invasive and cost-saving procedures, and it is emerging the concept to use it for the detection of inflammatory biomarkers. To this purpose, the present review aims to discuss the advantages and challenges of using standard and cutting-edge techniques to discover salivary biomarkers which may be used in diagnosis/therapy of several chronic diseases with inflammatory consequences with the pursuit to possibly replace conventional paths with detectable soluble mediators in saliva. Specifically, the review describes the procedures used for saliva collection, the standard approaches for the measurement of salivary biomarkers and the novel methodological strategies such as biosensors to improve the quality of care for chronically affected patients.
A Phase I study of Milademetan (DS3032b) in combination with low dose cytarabine with or without venetoclax in acute myeloid leukemia: Clinical safety, efficacy, and correlative analysis
Authors: Senapati Jayastu , Muftuoglu Muharrem , Ishizawa Jo , Abbas Hussein A. , Loghavi Sanam , Borthakur Gautam , Yilmaz Musa , Issa Ghayas C. , Dara Samuel I. , Basyal Mahesh , Li Li , Naqvi Kiran , Pourebrahim Rasoul , Jabbour Elias J. , Kornblau Steven M. , Short Nicholas J. , Pemmaraju Naveen , Garcia-Manero Guillermo , Ravandi Farhad , Khoury Joseph , Daver Naval , Kantarjian Hagop M. , Andreeff Michael , DiNardo Courtney D.
Published: June 2023

In TP53 wild-type acute myeloid leukemia (AML), inhibition of MDM2 can enhance p53 protein expression and potentiate leukemic cell apoptosis. MDM2 inhibitor (MDM2i) monotherapy in AML has shown modest responses in clinical trials but combining options of MDM2i with other potent AML-directed agents like cytarabine and venetoclax could improve its efficacy. We conducted a phase I clinical trial (NCT03634228) to study the safety and efficacy of milademetan (an MDM2i) with low-dose cytarabine (LDAC)±venetoclax in adult patients with relapsed refractory (R/R) or newly diagnosed (ND; unfit) TP53 wild-type AML and performed comprehensive CyTOF analyses to interrogate multiple signaling pathways, the p53-MDM2 axis and the interplay between pro/anti-apoptotic molecules to identify factors that determine response and resistance to therapy. Sixteen patients (14 R/R, 2 N/D treated secondary AML) at a median age of 70 years (range, 23–80 years) were treated in this trial. Two patients (13%) achieved an overall response (complete remission with incomplete hematological recovery). Median cycles on trial were 1 (range 1–7) and at a median follow-up of 11 months, no patients remained on active therapy. Gastrointestinal toxicity was significant and dose-limiting (50% of patients ≥ grade 3). Single-cell proteomic analysis of the leukemia compartment revealed therapy-induced proteomic alterations and potential mechanisms of adaptive response to the MDM2i combination. The response was associated with immune cell abundance and induced the proteomic profiles of leukemia cells to disrupt survival pathways and significantly reduced MCL1 and YTHDF2 to potentiate leukemic cell death. The combination of milademetan, LDAC±venetoclax led to only modest responses with recognizable gastrointestinal toxicity. Treatment-induced reduction of MCL1 and YTHDF2 in an immune-rich milieu correlate with treatment response.
Neurokinin-1 receptor drives PKCɑ-AURKA/N-Myc signaling to facilitate the neuroendocrine progression of prostate cancer
Authors: Zhang Xiao-Wei , Li Jing-Yi , Li Lin , Hu Wen-Qian , Tao Yan , Gao Wen-Yan , Ye Zi-Nuo , Jia Hao-Yuan , Wang Jia-Nan , Miao Xiao-Kang , Yang Wen-Le , Wang Rui , Mou Ling-Yun
Published: June 2023

The widespread application of antiandrogen therapies has aroused a significant increase in the incidence of NEPC, a lethal form of the disease lacking efficient clinical treatments. Here we identified a cell surface receptor neurokinin-1 (NK1R) as a clinically relevant driver of treatment-related NEPC (tNEPC). NK1R expression increased in prostate cancer patients, particularly higher in metastatic prostate cancer and treatment-related NEPC, implying a relation with the progression from primary luminal adenocarcinoma toward NEPC. High NK1R level was clinically correlated with accelerated tumor recurrence and poor survival. Mechanical studies identified a regulatory element in the NK1R gene transcription ending region that was recognized by AR. AR inhibition enhanced the expression of NK1R, which mediated the PKCα-AURKA/N-Myc pathway in prostate cancer cells. Functional assays demonstrated that activation of NK1R promoted the NE transdifferentiation, cell proliferation, invasion, and enzalutamide resistance in prostate cancer cells. Targeting NK1R abrogated the NE transdifferentiation process and tumorigenicity in vitro and in vivo. These findings collectively characterized the role of NK1R in tNEPC progression and suggested NK1R as a potential therapeutic target.
SMYD3 drives the proliferation in gastric cancer cells via reducing EMP1 expression in an H4K20me3-dependent manner
Authors: Zeng Yi , Ma Gang , Cai Fenglin , Wang Pengliang , Liang Han , Zhang Rupeng , Deng Jingyu , Liu Yong
Published: June 2023

Protein lysine methyltransferase SET and MYND domain-containing 3 (SMYD3) is aberrantly expressed in various cancer settings. The mechanisms that SMYD3 activates the expression of critical pro-tumoral genes in an H3K4me3-dependent manner have been well described in previous reports. Besides H3K4me3, H4K20me3 is another catalytic product of SMYD3, however it is a transcriptionally repressive hallmark. Since it is not clear that how SMYD3-elicited transcriptionally repressive program functions in cancer, we used gastric cancer (GC) as a model to investigate the roles of SMYD3-H4K20me3. Herein, online bioinformatics tools, quantitative PCR, western blotting and immunohistochemistry assays demonstrated that SMYD3 expression was markedly increased in GC tissues from our institutional and The Cancer Genome Atlas (TCGA) cohort. Additionally, aberrantly increased SMYD3 expression was closely associated with aggressive clinical characteristics and poor prognosis. Depletion of endogenous SMYD3 expression using shRNAs significantly attenuates the proliferation in GC cells and Akt signaling pathway in vitro and in vivo. Mechanistically, chromatin immunoprecipitation (ChIP) assay showed that SMYD3 epigenetically repressed the expression of epithelial membrane protein 1 (EMP1) in an H4K20me3-dependent manner. Gain-of-function and rescue experiments validated that EMP1 inhibited the propagation of GC cells and reduced p-Akt (S473) level. Based on these data, pharmaceutical inhibition of SMYD3 activity using the small inhibitor BCI-121 deactivated Akt signaling pathway in GC cells and further impaired the cellular viability in vitro and in vivo. Together, these results demonstrate that SMYD3 promotes the proliferation in GC cells and may be a valid target for therapeutic intervention of patients with GC.
High glucose induces tau hyperphosphorylation in hippocampal neurons via inhibition of ALKBH5-mediated Dgkh m6A demethylation: a potential mechanism for diabetic cognitive dysfunction
Authors: Qu Minli , Zuo Linhui , Zhang Mengru , Cheng Peng , Guo Zhanjun , Yang Junya , Li Changjun , Wu Jing
Published: June 2023

Tau hyperphosphorylation in hippocampal neurons has an important pathogenetic role in the development of diabetic cognitive dysfunction. N6-methyladenosine (m6A) methylation is the most common modification of eukaryotic mRNA and is involved in regulating diverse biological processes. However, the role of m6A alteration in tau hyperphosphorylation of hippocampus neurons has not been reported. We found lower ALKBH5 expression in the hippocampus of diabetic rats and in HN-h cells with high-glucose intervention, accompanied by tau hyperphosphorylation. ALKBH5 overexpression significantly reversed tau hyperphosphorylation in high-glucose-stimulated HN-h cells. Furthermore, we found and confirmed by m6A–mRNA epitope transcriptome microarray and transcriptome RNA sequencing coupled with methylated RNA immunoprecipitation that ALKBH5 regulates the m6A modification of Dgkh mRNA. High glucose inhibited the demethylation modification of Dgkh by ALKBH5, resulting in decreases in Dgkh mRNA and protein levels. Overexpression of Dgkh reversed tau hyperphosphorylation in HN-h cells after high-glucose stimulation. Overexpression of Dgkh by adenovirus suspension injection into the bilateral hippocampus of diabetic rats significantly ameliorated tau hyperphosphorylation and diabetic cognitive dysfunction. In addition, ALKBH5 targeted Dgkh to activate PKC-α, leading to tau hyperphosphorylation under high-glucose conditions. The results of this study reveal that high glucose suppresses the demethylation modification of Dgkh by ALKBH5, which downregulates Dgkh and leads to tau hyperphosphorylation through activation of PKC-α in hippocampal neurons. These findings may indicate a new mechanism and a novel therapeutic target for diabetic cognitive dysfunction.
Immunoception: the insular cortex perspective
Authors: Rolls Asya
Published: June 2023

To define the systemic neuroimmune interactions in health and disease, we recently suggested immunoception as a term that refers to the existence of bidirectional functional loops between the brain and the immune system. This concept suggests that the brain constantly monitors changes in immune activity and, in turn, can regulate the immune system to generate a physiologically synchronized response. Therefore, the brain has to represent information regarding the state of the immune system, which can occure in multiple ways. One such representation is an immunengram, a trace that is partially stored by neurons and partially by the local tissue. This review will discuss our current understanding of immunoception and immunengrams, focusing on their manifestation in a specific brain region, the insular cortex (IC).
Ferromagnetism emerged from non-ferromagnetic atomic crystals
Authors: Gong Cheng , Zhang Peiyao , Norden Tenzin , Li Quanwei , Guo Zhen , Chaturvedi Apoorva , Najafi Arman , Lan Shoufeng , Liu Xiaoze , Wang Yuan , Gong Shi-Jing , Zeng Hao , Zhang Hua , Petrou Athos , Zhang Xiang
Published: June 2023

The recently emerged ferromagnetic two-dimensional (2D) materials provide unique platforms for compact spintronic devices down to the atomic-thin regime; however, the prospect is hindered by the limited number  of ferromagnetic 2D materials discovered with limited choices of magnetic properties. If 2D antiferromagnetism could be converted to 2D ferromagnetism, the range of 2D magnets and their potential applications would be significantly broadened. Here, we discovered emergent ferromagnetism by interfacing non-magnetic WS2 layers with the antiferromagnetic FePS3. The WS2 exhibits an order of magnitude enhanced Zeeman effect with a saturated interfacial exchange field ~38 Tesla. Given the pristine FePS3 is an intralayer antiferromagnet, the prominent interfacial exchange field suggests the formation of ferromagnetic FePS3 at interface. Furthermore, the enhanced Zeeman effect in WS2 is found to exhibit a strong WS2-thickness dependence, highlighting the layer-tailorable interfacial exchange coupling in WS2-FePS3 heterostructures, which is potentially attributed to the thickness-dependent interfacial hybridization.
Importance of subsurface water for hydrological response during storms in a post-wildfire bedrock landscape
Authors: Atwood Abra , Hille Madeline , Clark Marin Kristen , Rengers Francis , Ntarlagiannis Dimitrios , Townsend Kirk , West A. Joshua
Published: June 2023

Wildfire alters the hydrologic cycle, with important implications for water supply and hazards including flooding and debris flows. In this study we use a combination of electrical resistivity and stable water isotope analyses to investigate the hydrologic response during storms in three catchments: one unburned and two burned during the 2020 Bobcat Fire in the San Gabriel Mountains, California, USA. Electrical resistivity imaging shows that in the burned catchments, rainfall infiltrated into the weathered bedrock and persisted. Stormflow isotope data indicate that the amount of mixing of surface and subsurface water during storms was similar in all catchments, despite higher streamflow post-fire. Therefore, both surface runoff and infiltration likely increased in tandem. These results suggest that the hydrologic response to storms in post-fire environments is dynamic and involves more surface-subsurface exchange than previously conceptualized, which has important implications for vegetation regrowth and post-fire landslide hazards for years following wildfire.
Spin current driven by ultrafast magnetization of FeRh
Authors: Kang Kyuhwe , Omura Hiroki , Yesudas Daniel , Lee OukJae , Lee Kyung-Jin , Lee Hyun-Woo , Taniyama Tomoyasu , Choi Gyung-Min
Published: June 2023

Laser-induced ultrafast demagnetization is an important phenomenon that probes arguably the ultimate limits of the angular momentum dynamics in solid. Unfortunately, many aspects of the dynamics remain unclear except that the demagnetization transfers the angular momentum eventually to the lattice. In particular, the role and origin of electron-carried spin currents in the demagnetization process are debated. Here we experimentally probe the spin current in the opposite phenomenon, i.e., laser-induced ultrafast magnetization of FeRh, where the laser pump pulse initiates the angular momentum build-up rather than its dissipation. Using the time-resolved magneto-optical Kerr effect, we directly measure the ultrafast-magnetization-driven spin current in a FeRh/Cu heterostructure. A strong correlation between the spin current and the magnetization dynamics of FeRh is found even though the spin filter effect is negligible in this opposite process. This result implies that the angular momentum build-up is achieved by an angular momentum transfer from the electron bath (supplier) to the magnon bath (receiver) and followed by the spatial transport of angular momentum (spin current) and dissipation of angular momentum to the phonon bath (spin relaxation).