bluuebunny/crossref_metadata_2025 huggingface dataset:
Étude qualitative sur la santé psychologique d’étudiantes en psychoéducation
Authors: Turgeon Lyse , Thouin Éliane , Ayotte Emmanuelle , Marion Élodie , Vaillancourt Jessica , Nault-Brière Frédéric , Plusquellec Pierrich
Published: May 2023

Bien avant l’avènement de la crise liée à la COVID-19, la santé psychologique étudiante constituait une source de préoccupation majeure pour les institutions d’enseignement supérieur. Plusieurs enquêtes avaient montré que la détresse psychologique des étudiants universitaires est très élevée, tout comme l’utilisation de services psychologiques et la consommation de médicaments psychotropes. Certaines études suggèrent que cette détresse est plus élevée dans les domaines d’étude liés à la relation d’aide. Cependant, les données à ce sujet sont encore très limitées. Notre étude a pour objectif de comprendre ce qui influence la santé psychologique des étudiants en relation d’aide ainsi que les pistes d’action envisageables. Durant l’année 2018-2019, nous avons mené une étude qualitative interprétative. Onze groupes de discussion ont été réalisés auprès de 74 étudiantes en psychoéducation, de professeurs, de chargés de cours, de superviseurs de stages et de membres du personnel de soutien. Les résultats ont été analysés en utilisant le modèle écologique de Bronfenbrenner (1977). Les données sont présentées selon : 1) l’ontosystème (facteurs individuels); 2) le microsystème (milieux de vie, comme l’université et le milieu de stages); 3) le mésosystème (interactions entre les différents milieux de vie, p. ex. cohérence entre le milieu de stages et l’université); 4) l’exosystème (structures, règles, etc.); 5) le macrosystème (éléments culturels et sociétaux) et 6) le chronosystème (dimension temporelle). La discussion présente une série de recommandations visant l’amélioration de la santé psychologique étudiante.
S’appuyer sur les perceptions des élèves du primaire pour favoriser la qualité des interactions en classe : élaboration et validation d’un questionnaire
Authors: Beaudoin Manon , Nadeau Marie-France , Lessard Anne
Published: May 2023

Les interactions en classe influencent la réussite éducative de tous les élèves. Le modèle Teaching Through Interactions (Hamre et Pianta, 2007) définit celles qui prennent place entre les élèves et l’enseignant selon trois domaines et dix dimensions. Bien qu’une grille d’observation permette de faire un portrait de classe, celle-ci ne tient pas compte de la perception des élèves qui est pourtant identifiée comme une composante-clé aux pratiques inclusives. Conséquemment, un questionnaire a été développé et validé pour brosser un portrait des interactions en classe telles que perçues par des élèves québécois de 4e, 5e et 6e année (n = 574, 53 % filles). Les analyses suggèrent que l’outil est valide, quoique certaines nuances doivent être considérées. Les indices de cohérence interne sont satisfaisants sur les trois domaines (α > 0,8) tandis qu’ils sont faibles à acceptables selon les dix dimensions (0,51 < α < 0,78). Des analyses factorielles confirmatoires soutiennent la structure à trois domaines et dix dimensions (X2/dl < 5, IAC > 0,8, RCMEA < 0,6). Les réponses des élèves suggèrent qu’ils entretiennent des perceptions favorables des interactions de leur classe pour les trois domaines (3,87 < M < 4,04 sur 5) et que le « Respect du point de vue de l’élève » est la dimension la plus faible. Ces résultats laissent envisager que le questionnaire est un outil complémentaire pour les enseignants et autres intervenants scolaires afin de les orienter sur des cibles d’intervention favorisant les interactions de la classe, en prenant appui sur l’expérience des élèves.
Identification of epigenetic modulators as determinants of nuclear size and shape
Authors: Schibler Andria C , Jevtic Predrag , Pegoraro Gianluca , Levy Daniel L , Misteli Tom
Published: May 2023

The shape and size of the human cell nucleus is highly variable among cell types and tissues. Changes in nuclear morphology are associated with disease, including cancer, as well as with premature and normal aging. Despite the very fundamental nature of nuclear morphology, the cellular factors that determine nuclear shape and size are not well understood. To identify regulators of nuclear architecture in a systematic and unbiased fashion, we performed a high-throughput imaging-based siRNA screen targeting 867 nuclear proteins including chromatin-associated proteins, epigenetic regulators, and nuclear envelope components. Using multiple morphometric parameters, and eliminating cell cycle effectors, we identified a set of novel determinants of nuclear size and shape. Interestingly, most identified factors altered nuclear morphology without affecting the levels of lamin proteins, which are known prominent regulators of nuclear shape. In contrast, a major group of nuclear shape regulators were modifiers of repressive heterochromatin. Biochemical and molecular analysis uncovered a direct physical interaction of histone H3 with lamin A mediated via combinatorial histone modifications. Furthermore, disease-causing lamin A mutations that result in disruption of nuclear shape inhibited lamin A-histone H3 interactions. Oncogenic histone H3.3 mutants defective for H3K27 methylation resulted in nuclear morphology abnormalities. Altogether, our results represent a systematic exploration of cellular factors involved in determining nuclear morphology and they identify the interaction of lamin A with histone H3 as an important contributor to nuclear morphology in human cells.
Morphometric analysis of odontoid process among Arab population: a retrospective cone beam CT study
Authors: Uthman Asmaa , Salman Basheer , Shams Aldeen Hawraa , Marei Hesham , Al-Bayati Sura F. , Al-Rawi Natheer H.
Published: May 2023

Objective

This study aims to evaluate the feasibility of using cone beam computed tomography (CBCT) scans to assess the odontoid process diameter in the Arab population and to determine whether one or two cortical screws can be used for treating odontoid fractures.

Methods

The odontoid process of 142 individuals aged 12–75 years, including 72 males (mean age: 35.5) and 70 females (mean age: 36.2), were analyzed using CBCT scans. The sagittal and coronal CBCT views were used to evaluate the antero-posterior (AP) and transverse diameters of the odontoid process.

Results

Males had substantially bigger transverse and AP diameters of the odontoid process than females (p < 0.05 & P < 0.01 respectively). Among the sample, 97 individuals (67.4%) had external transverse diameter (METD) of less than 9 mm which is slightly bigger than that of Indians and 48 individuals (31.83%) had enough room for two 3.5 mm or two 2.7 mm screws as their METD was more than 9 mm like that of Greek and Turkish. Age had no significant impact on the morphometric measurements of the odontoid process.

Conclusion

More than sixty percent of the sample had METDs of less than 9 millimeters, indicating that a single 4.5-mm Herbert screw may be suggested for fixing fractured odontoid processes in the Arab population.
teoría del marco de memoria-predicción y los cognits en el origen y la organización cortical del lenguaje
Authors: Martín-Pascual Miguel Ángel , Andreu-Sánchez Celia
Published: May 2023

Tradicionalmente se consideraba al lenguaje como ejemplo de fenómeno cultural y social, en contraposición a lo natural o biológico. Esta distinción de lo cultural adquirido (nurture) frente a lo natural (nature) refleja, en realidad, la brecha previa entre las dos culturas de las ciencias humanas y naturales que Snow pretendía solucionar ya en 1951. Hoy se considera que el lenguaje tiene una profunda base biológica con pruebas bien asentadas en la comunidad científica. Para afirmar que la facultad del lenguaje depende de los genes, parece que hace falta un marco más amplio de comprensión de la cognición humana donde el lenguaje se integraría con el resto de procesos cognitivos neurogenéticos y neurofisiológicos en la interacción de la humanidad con la realidad.
Sur la notion linguistique de vicariance
Authors: Bidaud Samuel
Published: May 2023

Nous proposons ici une définition de la notion de vicariance. En effet, les grammairiens français qui utilisent ce concept ne l’ont pas défini de façon précise. Nous verrons quelle est la spécificité des mots vicariants, qui peuvent être définis comme des mots avec un sémantisme abstrait qui sont sémantiquement identiques avec leur antécédent
metáfora gramatical en los textos escolares de Ciencias Sociales en español
Authors: Moss Gillian , Barletta Manjarrés Norma , Chamorro Miranda Diana , Mizuno Haydar Jorge
Published: May 2023

En el presente artículo abordamos el estudio de la metáfora gramatical en español, específicamente en textos escolares de Ciencias Sociales empleados en Colombia. Nuestro interés se centra en analizar, desde la perspectiva de la Gramática Sistémico-Funcional (Halliday, 1994, 2004b), las particularidades de la metáfora gramatical ideacional en español y sus implicaciones para la formación ciudadana y el aprendizaje. El corpus lo conforman tres capítulos de textos para octavo grado que aluden a la Revolución Industrial. El proceso seguido para realizar nuestros análisis nos ha permitido identificar la presencia de metáforas gramaticales en los términos hallidayanos: nominalizaciones de procesos y cualidades, y el uso de verbos causales en lugar de conjunciones. Asimismo, hemos identificado otros tipos de metáforas: cláusulas no ergativas, presente histórico, participantes no animados. En el artículo resaltamos la importancia del desempaque de las metáforas en los procesos de análisis y también de enseñanza y aprendizaje, ya que a través de él se visibiliza la información escondida en la metáfora.
Estructura informativa y fisonomía acústica en oraciones copulativas ecuacionales
Authors: Pinuer Rodríguez Claudio , Ruiz Mella Magaly , Pérez Muñoz Hernán , Soto-Barba Jaime
Published: May 2023

Este artículo presenta los resultados de un estudio acústico y gramatical de 21 oraciones ecuacionales o copulativas enfáticas, a través de un análisis melódico (Cantero, 2002; y Cantero y Font, 2009) seguido de una interpretación pragmática de los principales hallazgos en términos de su funcionalidad como correlatos fónicos de la fisonomía informativa que singulariza a las oraciones ecuacionales como construcciones de foco (Gutiérrez, 1997; Cid y Maluenda, 2005; NGLE 2009) especializadas en realzar un segmento oracional con independencia a su grado de novedad (dado o nuevo) y función comunicativa (contraste o ampliación). La investigación se desarrolló bajo los principios generales del funcionalismo (Silva-Corvalán, 2001; Halliday y Matthiessen, 2004; Halliday, 2005), por lo cual los rasgos prosódicos, sintácticos y pragmáticos relevados en el análisis se consideraron pertinentes para las diversas presentaciones de la oración copulativa enfática. Los resultados mostraron una tendencia robusta en la realización del acento enfático en posición inicial de enunciado, con independencia al tipo focal (contrastivo o neutro) y modalidad ecuacional (hendida, pseudohendida y pseudohendida inversa).
Siniestros viales en la Zona Metropolitana del Valle de México.
Authors: Juarez Flores Jorge , Hernández Ortiz Kevin
Published: May 2023

Los siniestros viales constituyen una de las pandemias con mayor mortalidad del siglo XXI. En 2018, perdieron la vida 1.35 millones de personas en el mundo a causa de traumatismos por siniestros viales, en la región de América Latina y el Caribe se registraron 155,000 muertes y 16,725 en México por este hecho. En la región y en la Zona Metropolitana del Valle de México, los siniestros viales se encuentran dentro de las diez causas de muerte en población general, junto a enfermedades crónicas no transmisibles como la diabetes y el riesgo cardiovascular; superando en letalidad al VIH/SIDA, tuberculosis o enfermedades diarreicas. El objetivo del presente artículo es mostrar a la Zona Metropolitana del Valle de México, como punto clave donde se desarrollan de manera prominente, los efectos de los siniestros viales; debido a su alta densidad poblacional, nivel de movilidad elevado, medios de transporte compartidos e infraestructura vial limitada. Lejos de mostrar los datos como hechos, se busca el reconocer los siniestros viales como pandemia ignorada, evidenciar su magnitud e impacto en México y la región, de tal modo, buscar medidas para reducir muertes en población general y particularmente en grupos vulnerables: peatones, ciclistas y motociclistas.
Participación ciudadana anticipada en proyectos de riego en Chile
Authors:   Estudiante de Magíster, Universidad Católica, Herrera Javiera
Published: May 2023

En los proyectos desarrollados por el Estado, como los proyectos de riego, se consideran procesos de participación ciudadana anticipada, los cuales pueden ser una excelente manera de lograr que el diseño de los proyectos sea acorde con las necesidades de sus potenciales beneficiarios y adecuados parala realidad de los territorios en los que se emplazarán. De esta misma forma, los procesos participativos pueden ser una adecuada forma de canalizar las controversias existentes en los territorios, la percepción de pocas instancias de participación e involucramiento de los habitantes en la toma de decisiones, y así gestionar adecuadamente los potenciales conflictos socioambientales asociados a obras de infraestructura hídrica, las cuales se presentan potencialmente conflictivas por su naturaleza. El presente artículo da cuenta de algunas experiencias y de la evolución de los procesos participativos desarrollados por la Comisión Nacional de Riego (CNR) en sus estudios y proyectos y la disminución de las conflictividades en los territorios.
A implementação de ERP nos hospitais universitários federais brasileiros: uma análise institucional
Authors: Lordello Heloisa Siqueira , Caria Ana , Oliveira Lídia
Published: May 2023

Os Hospitais Universitários Federais (HUFs) no Brasil integram o sistema público de saúde (Sistema Único de Saúde) e têm grande importância neste, pois são responsáveis por exercer assistência, ensino, pesquisa e extensão. A complexidade destas instituições, juntamente com a necessidade de proporcionar serviços de elevada qualidade, faz com que o seu gerenciamento seja particularmente complexo. Este artigo analisa o processo de mudança dos HUFs brasileiros decorrentes da implementação de um novo ERP de gestão hospitalar com foco no paciente. Trata-se de um estudo qualitativo que adota uma abordagem interpretativa e utiliza a Nova Sociologia Institucional. São analisadas as respostas dos HUFs às pressões institucionais no período de 2009-2018, com recurso a análise documental e entrevistas semiestruturadas. Os Hospitais Universitários Federais (HUFs) aderentes à gestão privada sofreram pressões isomórficas para a implementação do ERP e as práticas existentes foram descontinuadas. Constatou-se resistência dos funcionários da parte assistencial, que relutaram em compartilhar informações para legitimar estruturas de poder estabelecidas. Verificou-se falta de investimentos na infraestrutura, de planejamento e de experiência do pessoal e do fornecedor, para além de muitas alterações no sistema e processos mal implantados. Esta investigação contribui para a compreensão do processo de mudança em hospitais universitários públicos com a implementação de gestão privada e sistemas ERP no contexto brasileiro. Fornece também novos insights sobre o comportamento das organizações e seus atores em contextos institucionais complexos, bem como das condições sob as quais as organizações resistem às pressões institucionais. O estudo contribui ainda para entender como o ambiente institucional influencia e molda as práticas organizacionais dos HUFs.
Towards Doubling of Farmer’s Income in India: A Critical Appraisal
Authors: Deepika  , Kathpalia Jatesh , Tyagi Rashmi , Kumari Vinod
Published: May 2023

Farmers have been performing agriculture and allied activities since the dawn of human civilization. The agriculture industries rely heavily on the hard work and dedication of the farmers to provide food and other resources to the entire population. Despite, their vital role many farmers struggle to make ends meet due to low revenue of farm produce. The paper addresses the current nature of Indian agriculture, the change in the pattern variables governing them, and the challenges faced by Indian farmers at large. Doubling farmer’s income is necessary to address these challenges and to ensure sustainable agriculture. Furthermore, it can help in improving their livelihoods and well-being by enabling them to meet their basic needs. The researcher’s focus will be towards generating substantial returns for the farmers. A thorough exposition will also be on the welfare approach and how the government’s decisive role in policymaking will go to lengths to protect the interests of the farmers. In addition to these, a discussion of the novel techniques will also find a place in the paper. The paper will eventually end on a note providing a sociological analysis of how the improved, innovative technologies have are harbinger of new era for Indian agriculture in general and farmers in particular.
Study the Socio-economic Status of Fishers of Egra-I Block of Purba Medinipur District, West Bengal, India
Authors: Bera Sushil , Maity Joydev
Published: May 2023

The present study was carried out to assess the socio-economic condition of fishermen of Egra-I block in Purba Medinipur district during the period from August 2022 to December 2022. The data were collected from 65 fishermen through survey sheet. The study was executed on the basis of personal interview. The study shows that most of the fishermen (95%) were Hindus, where 5% Muslims. The educational level of fishermen was very poor, 2% illiterate, 75% Primary pass, 15% Secondary pass and only 8% Higher Secondary pass. The housing condition of fishermen is maximum kutcha (65%), pucca (25%) and semi-pucca (10%). It was observed that there were 85% nuclear and 15% joint families. The annual income of fishermen varies from Rs.45,000 to Rs.1,00000. The main occupation of fishermen is the cultivation of paddy and ground nut. Fishing is the secondary occupation.
Effect of Carbohydrate Type on Brain Composition and Senescence in Aging, Hyperinsulinemia-prone OBESE LA/Ntul//-cp Rats
Authors: Tulp Orien L.
Published: May 2023

To determine if phenotype and the carbohydrate type resulted in alterations in brain composition in the obese phenotype of the congenic LA/Ntul//-cp rat, groups (n= 8 rats/group) of male littermate lean and obese rats were fed standardized isocaloric diets containing 54% (w/w) cornstarch (ST diet) or 54% (w/w) sucrose (SUC diet) from 1 until 10.5 ± 0.5 months of age. The obese phenotype of his strain develops early onset chronic hyperinsulinemia without NIDDM associated with hypertrophic-hyperplastic obesity during early postweaning growth. Brain tissues were dissected, and representative aliquots subjected to total fat, protein, and DNA analysis. Body weights of obese >> lean and were greater when fed the SUC than the ST diet in both phenotypes. Brain mass of lean > obese, and diet was associated with modestly lower brain weights in rats fed the SUC than the ST diet. Brain total Protein and DNA content of lean rats were > obese rats and were modestly Lower in SUC than ST fed rats in both phenotypes, but the percent of lipid content was proportional to brain mass. Total body fat mass of obese was significantly greater than occurred in lean littermates and was only modestly greater in SUC than ST fed rats in both phenotypes. These results indicate that brain growth and cellular development is impaired in the aging, hyperinsulinemia-prone obese phenotype of this strain, were further impaired when fed SUC than ST diets, and the decreased brain parameters were likely associated with development of a chronic neuronal inflammatory syndrome common to excessive fat accretion and obesity, resulting in premature brain senescence.
Evaluating the Effectiveness of Low Impact Development Practices against Climate Induced Extreme Floods
Authors: Ghimire Amrit Babu , Banjara Mandip , Bhusal Amrit , Kalra Ajay
Published: May 2023

Short but extreme flooding events have been frequent and severe globally due to climate change and urbanization in recent years. Similarly, researchers, scientists, and water managers are suggesting the application of sustainable flood management strategies such as Low Impact Development (LID) to mitigate the impacts of such extreme flooding events. However, most of these strategies have primarily been evaluated using historical precipitation events, which may not accurately represent the impact of climate-induced flooding events, which are projected to become more extreme. In this context, this study assesses the effectiveness of LIDs in combating climate change-induced flooding events. The North American Regional Climate Change Assessment Program (NARCCAP) climate model was applied in this study to quantify the magnitude of future projected storm depths, which are expected to increase due to climate change. Similarly, Personal Computer Storm Water Management Model (PCSWMM) was used to develop a rainfall-runoff simulation model and to assess the effectiveness of three LID techniques (Permeable Pavement, Green Roof, and Bio-Retention Cell) in reducing surface runoff under various climate scenarios. The results revealed that under the climate change scenarios the future projected design depths are expected to increase by up to 104%.  Similarly, peak discharge, and total flooding volume were found to increase by 37.72% and 88.73%, respectively under the most extreme climate change scenario. Furthermore, the study demonstrated that applying LID strategies decreases peak discharge, offering a viable solution to tackle flooding events induced by climate change. The results illustrated the performance of permeable pavement was superior in reducing the peak discharge by up to 28.57%. Similarly, applying green roofs and bioretention cells reduced the peak discharge by up to 19.93% and 14.25%, respectively.
Evaluation of F1 Crosses of Brinjal (Solanum melongena L.) Landraces for Fruit Yield, Quality and Tolerance to Bacterial Wilt
Authors: Mishra Subha Laxmi , Tripathy P. , Sahu G. S. , Lenka D. , Mishra M. K. , Tripathy S. K.
Published: May 2023

Field experiment was carried out at All India Coordinated Research Project on Vegetable Crops, OUAT, Bhubaneswar, Odisha, India in order to identify the superior F1 crosses for marketable fruit yield quality and resistance to bacterial wilt. All total 21 F1 crosses evolved from seven distinctly diverse local landraces of brinjal along with a hybrid check, Mahy Green were evaluated by adopting Randomized Block Design and replicated twice in rabi 2021-2022. Results revealed significant variations among various fruit quality attributes (TSS: 4.32 oBrix to 6.00 oBrix and ascorbic acid content of fruit: 5.10 mg100g-1 to 7.10 mg100g-1), incidence of bacterial wilt (30 DAT: 0.00% to 4.17%, 60 DAT: 0.00% to 12.50% and 90 DAT: 0.00% to 20.83%). Out of 21 crosses, nine cross showed immune reaction to bacterial wilt at 90 DAT. The marketable fruit yield plant-1 varied significantly from 1.00 kg to 1.99 kg. The F1 cross viz. BBSR-08-2 × Selection from BBSR-145-1(1.99 kg) recorded significantly highest fruit yield plant-1 followed by BBSR-08-2 × BBSR-10-25(1.87 kg) and BBSR-08-2 × BBSR-10-26 (1.81 kg). Thus, it may be concluded that, F1 crosses obtained from local landraces of brinjal viz., BBSR-08-2 × Selection from BBSR-145-1, BBSR-08-2 × BBSR-10-25 and BBSR-08-2 × BBSR-10-26 may be recommended for higher marketable fruit yield, fruit quality and over all resistance to bacterial wilt for higher profit. These local landraces may also be used for future brinjal improvement programme towards development varieties with higher fruit yield quality and resistance to bacterial wilt.
Luana, Eliza e a Lei Maria da Penha: o acontecimento em discussão//Luana, Eliza and Maria da Penha law: the event under discussion
Authors: Sarmento Rayza , Mendonça Ricardo Fabrino
Published: May 2023

O artigo propõe-se a discutir o papel de acontecimentos na promoção de debates sobre temas de interesse público. O objetivo é compreender se, e como, discussões morais são desencadeadas por eventos que mobilizam a atenção pública, amplamente noticiados por envolverem personalidades públicas. Para explorar tais questões, analisamos dois acontecimentos relacionados à violência doméstica e a implementação da Lei Maria da Penha: (1) a agressão envolvendo o ator Dado Dolabella e a atriz Luana Piovani e (2) o desaparecimento/assassinato de Eliza Samúdio, a partir de notícias publicadas nos jornais Folha de S. Paulo e O Globo. Utilizamos a noção de individuação do acontecimento para apresentá-los e constatamos que os eventos se revelam catalisadores importantes para debates morais sobre o tema em questão.
Processos interculturais em Baby do Brasil: caminhos para compreender o trânsito da cantora entre o gospel e o secular//Intercultural processes of Baby do Brasil: ways to understand the singer's transit between gospel and secular music
Authors: Pichiguelli Isabella , Silva Míriam Cristina Carlos
Published: May 2023

Esse artigo tem como objetivo compreender de que modo se dá a mistura de elementos distintos na incorporação que a cantora Baby do Brasil faz de linguagens e práticas da música gospel em seus shows ao retornar à música secular – assim chamada pela maioria dos que são evangélicos no Brasil – interpretando canções de sua carreira com os Novos Baianos e da fase solo, em um processo intercultural. Com base nos conceitos de dialogismo, de Mikhail Bakhtin, e de semiosfera, de Iuri M. Lotman, a pesquisa sugere que uma série de fatores encontrados ao redor do universo da cantora ou na própria história de vida da artista, textos externos e subtextos, permitem a mescla que Baby do Brasil faz de ambientes culturais desde muito separados pelos muros da doutrina evangélica e do mercado musical.
Jornalismo na ambiência das mídias sociais digitais: apropriação de características do Facebook em postagens de jornais brasileiros//Journalism in the ambience of digital social media: Facebook’s appropriation features in brazilian newspaper posts
Authors: Menezes Carvalho Luciana , Mariano da Rocha Barichello Eugenia
Published: May 2023

A partir da perspectiva sociotécnica da Ecologia dos Meios, as mídias são mais do que suportes, constituindo-se em ambiências com características que se desenvolvem na interação entre tecnologia e apropriações dos usuários. Assim, compreende-se que o jornalismo, ao se apropriar de um meio, adapta-se às suas lógicas. Na ambiência das mídias sociais digitais, características como hipertextualidade, multimidialidade, linguagem informal e conversacional, promocionalidade, participação e autorreferencialidade são apropriadas de modos distintos por parte das organizações jornalísticas em suas publicações. Neste texto, que integra uma pesquisa mais ampla, é descrita uma observação exploratória em dois corpora, de 2014 e 2015, constituídos de postagens de quatro jornais brasileiros em suas páginas no Facebook. São encontradas 19 características que podem ser atribuídas às lógicas das mídias sociais digitais no conjunto das publicações. Os resultados identificam uma adaptação maior a essa ambiência nos jornais Estadão e Zero Hora, em 2014. Entretanto, em 2015, Zero Hora é o que se apropria de mais características, seguido da Folha e do Estadão. Constata-se que O Globo demonstra um processo mais retraído de inserção nas lógicas dessas mídias nos períodos analisados.
Mapeando os Caminhos do Jornalismo Transmídia: a morte de Teori Zavascki em Zero Hora e nas interações dos leitores // Mapping the Paths of Transmedia Journalism: the death of Teori Zavascki in Zero Hora and in readers’ interactions
Authors: Zago Gabriela da Silva , Belochio Vivian de Carvalho
Published: May 2023

A possibilidade de distribuição multiplataforma vem trazendo transformações em todas as etapas do processo jornalístico. Mapear esses múltiplos caminhos pode ser um desafio na medida em que envolve rastrear diferentes plataformas, bem como a produção de diferentes atores. Isso porque, para além da notícia, o ambiente digital permite ainda a circulação de comentários, respostas e reações de leitores, em especial através dos espaços disponibilizados pelas redes sociais na internet. Com base nesse cenário, o artigo propõe a realização de análise das estratégias da narrativa transmidiática no jornalismo considerando-se o papel das interações com os públicos nessas ações. Para isso, aplica técnica de análise composta pelo mapeamento dos caminhos da estratégia de narrativa transmidiática de Zero Hora na cobertura da morte de Teori Zavascki que se completa com a verificação das trocas entre os leitores geradas a partir desses caminhos originalmente disponibilizados pelo veículo. Resultados apontam para uma complementaridade entre meios, com diferentes conteúdos circulando nos diferentes pontos de acesso à franquia. As interações dos leitores também diferem em cada espaço, com diferentes graus de contribuição e visibilidade.
A crítica de cinema enquanto um sistema promotor de crises: uma abordagem epistemológica//Film criticism as a crisis promoter system: an epistemological approach
Authors: Araújo Denize Correa , Vilela Teixeira Luiz Gustavo
Published: May 2023

Ao eleger critérios, recortes e métodos de abordagem, o exercício crítico se configura em um olhar epistemológico diante do cinema. A crítica de cinema é um meio possível pelo qual se chega ao cinema, refletindo sobre seu impacto no mundo. A proposta deste texto é examinar os mecanismos da crítica enquanto um sistema social, partindo da proposição de José Luiz Braga (2006) e promovendo um diálogo com pensadores clássicos do cinema, como André Bazin (2014) e Jean-Claude Bernardet (1986). Em se configurando a crítica como um sistema, deve-se compreender como a mesma se articula diante do cinema e da sociedade e quais são os mecanismos que operam estes sentidos.
Transcatheter Mitral Valve Repair for Degenerative Mitral Regurgitation
Authors: Makkar Raj R. , Chikwe Joanna , Chakravarty Tarun , Chen Qiudong , O’Gara Patrick T. , Gillinov Marc , Mack Michael J. , Vekstein Andrew , Patel Dhairya , Stebbins Amanda Lee , Gelijns Annetine C. , Makar Moody , Bhatt Deepak L. , Kapadia Samir , Vemulapalli Sreekanth , Leon Martin B.
Published: May 2023

Importance

There are limited data on the outcomes of transcatheter edge-to-edge mitral valve repair for degenerative mitral regurgitation (MR) in a real-world setting.

Objective

To evaluate the outcomes of transcatheter mitral valve repair for degenerative MR.

Design, Setting, and Participants

Cohort study of consecutive patients in the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapies Registry who underwent nonemergent transcatheter mitral valve repair for degenerative MR in the US from 2014 through 2022.

Exposure

Transcatheter edge-to-edge mitral valve repair with the MitraClip device (Abbott).

Main Outcomes and Measures

The primary end point was MR success, defined as moderate or less residual MR and a mean mitral gradient of less than 10 mm Hg. Clinical outcomes were evaluated based on the degree of residual MR (mild or less MR or moderate MR) and mitral valve gradients (≤5 mm Hg or >5 to <10 mm Hg).

Results

A total of 19 088 patients with isolated moderate to severe or severe degenerative MR who underwent transcatheter mitral valve repair were analyzed (median age, 82 years; 48% women; median Society of Thoracic Surgeons predicted risk of mortality with surgical mitral valve repair, 4.6%). MR success was achieved in 88.9% of patients. At 30 days, the incidence of death was 2.7%; stroke, 1.2%; and mitral valve reintervention, 0.97%. MR success compared with an unsuccessful procedure was associated with significantly lower mortality (14.0% vs 26.7%; adjusted hazard ratio, 0.49; 95% CI, 0.42-0.56; P < .001) and heart failure readmission (8.4% vs 16.9%; adjusted hazard ratio, 0.47; 95% CI, 0.41-0.54; P < .001) at 1 year. Among patients with MR success, the lowest mortality was observed in patients who had both mild or less residual MR and mean mitral gradients of 5 mm Hg or less compared with those with an unsuccessful procedure (11.4% vs 26.7%; adjusted hazard ratio, 0.40; 95% CI, 0.34-0.47; P < .001).

Conclusions and Relevance

In this registry-based study of patients with degenerative MR undergoing transcatheter mitral valve repair, the procedure was safe and resulted in successful repair in 88.9% of patients. The lowest mortality was observed in patients with mild or less residual MR and low mitral gradients.
Acute myeloid leukemia in elderly patients: New targets, new therapies
Authors: Park Hae J. , Gregory Mark A.
Published: May 2023

Prior to the past few years, the development of new therapies for acute myeloid leukemia (AML) has been disappointingly slow. For several decades, the standard therapy for AML has consisted of intensive induction chemotherapy, and potentially a subsequent hematopoietic stem cell transplant. Unfortunately, older patients are less responsive to, and are frequently unfit to tolerate, such intensive chemotherapy. Given that a majority of AML patients are elderly, this population has been most affected by the lack of newer less toxic therapies. However, in recent years, the treatment landscape for AML has dramatically shifted with the approval of many new drugs. As summarized in this review, several of these new drugs are targeted agents that are better tolerated than standard chemotherapy and could substantially benefit elderly patients. Although drug resistance remains a major concern, the treatment options for elderly AML patients are more numerous than ever before, bringing new promise for improved patient outcomes.
Skin sympathetic nerve activity as a biomarker for outcomes in spontaneous intracerebral hemorrhage
Authors: Wang Weiwei , Cheng Hongyi , Zhang Yike , Cui Chang , Lin Zhiqiao , Xing Yantao , Zhong Xiaoyuan , Liang Xichen , Cao Quan , Chen Yan , Chen Minglong
Published: May 2023

Objective

A rapid and accurate forecast for the early prognosis of ICH patients is challenging. This study investigated whether heart rate variability (HRV) and skin sympathetic nerve activity (SKNA) could prognosticate poor neurological outcomes in ICH patients.

Methods

Between November 2020 and November 2021, we studied 92 spontaneous ICH patients in the First Affiliated Hospital of Nanjing Medical University. Glasgow Outcome Scale (GOS) score at 2 weeks after the ICH was used to categorize patients into good and poor outcome groups. The modified Rankin Scale (mRS) assessed patients' ability to live independently for 1 year. We utilized a portable high‐frequency electrocardiogram (ECG) recording system to record the HRV and SKNA information in ICH patients and control participants.

Results

77 patients were eligible for the prediction of neurological outcome and were allocated into the good (n = 22) or poor (n = 55) outcome groups based on the GOS grade. In univariate logistic regression analysis, significant variables that could differentiate the outcomes were age, hypertension, tracheal intubation, Glasgow Coma Scale (GCS) score, existing intraventricular hemorrhage, white blood cells, neutrophil, lnVLF, lnTP, and aSKNA. Variables in the best fit multivariable logistic regression model were age, hypertension, GCS score, neutrophils, and aSKNA. The GCS score was the only independent risk factor for poor outcomes. At 30 days and 1 year of follow‐up, patients with lower aSKNA had poor outcomes.

Interpretation

ICH patients had reduced aSKNA, which could be a prognostic indicator. A lower aSKNA suggested a worse prognosis. The present data indicate that ECG signals could be helpful for prognosticating ICH patients.
Amide (n, π*) Transitions Enabled Clusteroluminescence in Solid‐State Carbon Dots
Authors: Li Hui‐Jun , Chen Yanlu , Wang Hao , Wang Huan , Liao Qiaobo , Han Sancan , Li Ying , Wang Ding , Li Guisheng , Deng Yonghui
Published: May 2023

Carbon dots (CDs) demonstrate great superiority in optoelectronic devices due to their tunable emission and photobleaching resistance properties. Although the fluorescence of CDs in solution has been extensively studied, their solid‐state fluorescence (SSF) mechanism still remains largely unexplored experimentally. Herein, solid‐state fluorescent CDs with unique clusteroluminescence (CL) generated from clusterization‐triggered emission are designed based on condensation between precursors with carboxyl and amino groups. The CDs demonstrate obvious concentration‐dependent fluorescence and quench‐resistant SSF, which is attributed to the activation of amide (n, π*) transition by the clusterization process. This sub‐luminophore is non‐luminescent at long wavelengths in isolated state, while it induces photoluminescence redshift via through‐space interaction in aggregated state. Besides, the SSF of CDs can be tuned from quenched to quenching‐resistant emission through amide formation, and the dominant fluorescent center of CDs solids is switchable from surface to edge state through amide passivation. Based on their long‐wavelength CL feature, high‐purity red light‐emitting diode devices exhibiting 656‐nm warm light are fabricated with the Commission Internationale de l´Eclairage (CIE) coordinates of (0.66, 0.34) and unchanged wavelength under different driving currents. These findings provide novel insights into the SSF mechanism of CDs and a universal strategy to construct fluorescent materials with tailored properties.
Calcium Phosphate Microcapsules as Multifunctional Drug Delivery Devices
Authors: Kost Jonas , Huwyler Jörg , Puchkov Maxim
Published: May 2023

More challenging active pharmaceutical ingredients are entering the market, spurring the introduction of novel drug delivery strategies that necessitate a paradigm shift from exhausted excipients to materials with combined actions and multiple functionalities. In this study, an inorganic calcium phosphate microparticle with a hollow internal structure is introduced as a biocompatible and multifunctional microcapsule: the template inverted particle (TIP). A robust process is presented to create a unique particle geometry, which is characterized by a particle size of 20 µm and a hollow cavity enclosed by a specially engineered porous shell. This study focuses on the characterization of TIP as an excipient for the design of solid dosage forms. The cavities in the particle centers serve as an encapsulation space, resulting in boosted water uptake capacity of 5.3 cm3 g−1. Benefiting from the material's high wettability and water uptake rates, TIP tablets immediately disperse in the oral cavity. Mechanistic studies reveal a viscoelastic behavior of empty TIP microcapsules in accordance with the Kelvin–Voigt model of a parallel spring‐dashpot configuration. The unique particle geometry is maintained during compaction thanks to its exceptional structural integrity. This study demonstrates how multifunctional TIP microcapsules can be applied as a pharmaceutical drug delivery device.
Ultra‐Fast Photonic Digital Polymerase Chain Reaction based on N‐Heterocyclic Carbene Self‐Assembled Monolayer
Authors: Kim Kyung Ho , Seo Sung Eun , Kim Jinyeong , Park Seon Joo , An Jai Eun , Shin Chan Jae , Ryu Choong‐Min , Lee Sung Woon , Nam Ho Chul , Yoon Tae Ho , Shin Jong Cheol , Kim Yu Kyung , Oh Hanseul , Hong Jung Joo , Kim Brian N. , Lee Kyoung G. , Song Hyun Seok , Lee Sang Hun , Kwon Oh Seok
Published: May 2023

A molecular diagnosis of the respiratory syncytial virus (RSV) without bulky and expensive instrumentation is of great importance for the early detection and prevention in a fast‐spreading pandemic. However, the current representative diagnostic methods have the limitation of being time‐consuming, cost, the processing time for polymerase chain reaction (PCR), and inaccurate for lateral flow assay (LFA), representatively. Herein, an integrated photonic digital PCR (dPCR) is developed with high‐velocity photonic scanner for in situ fluorescence detection by introducing the N‐heterocyclic carbene self‐assembled monolayer‐based Au film to prevent the quenching effect. The on‐site rapid molecular diagnostic platform shows the driving of 40 cycles in under 8 min and fluorescence scanning in under 7 min, resulting in a total analysis time within 15 min. In particular, the technology clearly demonstrates the classification of SARS‐CoV‐2 patients and healthy controls (99% in sensitivity, 98.6% in specificity, and 96.4% in accuracy with RdRp gene), comparing with standard RT‐qPCR. This platform can be utilized for prompt point‐of‐care molecular diagnostics in early diagnosis and large‐scale prevention of next pandemic spreading for upcoming infectious diseases and for the distinction diagnosis with other RSV.
Electronic‐State Modulation of Metallic Co‐Assisted Co7Fe3 Alloy Heterostructure for Highly Efficient and Stable Overall Water Splitting
Authors: Wang Xinyu , Xu Xiaoqin , Nie Yao , Wang Ruihong , Zou Jinlong
Published: May 2023

Manipulating electronic structure of alloy‐based electrocatalysts can eagerly regulate its catalytic efficiency and corrosion resistance for water splitting and fundamentally understand the catalytic mechanisms for oxygen/hydrogen evolution reactions (OER/HER). Herein, the metallic Co‐assisted Co7Fe3 alloy heterojunction (Co7Fe3/Co) embeds in a 3D honeycomb‐like graphitic carbon is purposely constructed as a bifunctional catalyst for overall water splitting. As‐marked Co7Fe3/Co‐600 displays the excellent catalytic activities in alkaline media with low overpotentials of 200 mV for OER and 68 mV for HER at 10 mA cm−2. Theoretical calculations reveal the electronic redistribution after coupling Co with Co7Fe3, which likely forms the electron‐rich state over interfaces and the electron‐delocalized state at Co7Fe3 alloy. This process changes the d‐band center position of Co7Fe3/Co and optimizes the affinity of catalyst surface to intermediates, thus promoting the intrinsic OER/HER activities. For overall water splitting, the electrolyzer only requires a cell voltage of 1.50 V to achieve 10 mA cm−2 and dramatically retains 99.1% of original activity after 100 h of continuous operation. This work proposes an insight into modulation of electronic state in alloy/metal heterojunctions and explores a new path to construct more competitive electrocatalysts for overall water splitting.
X‐Ray Nanoanalysis Revealing the Role of Electronically Active Passivation Layers in Perovskite X‐Ray film Detectors
Authors: Verdi Matteo , Ciavatti Andrea , Segura‐Ruiz Jaime , Basiricò Laura , Sorrentino Roberto , Goncalves Isabel Pinto , Petrozza Annamaria , Boscherini Federico , Fraboni Beatrice
Published: May 2023

X‐ray direct detectors based on hybrid lead‐halide perovskite have seen a dramatic increase of interest in the last years. A rush for the achievement of high performing devices drives the scientific community. In this context, several photoconductor sensors employ functional layers to increase the gain effect, but the full comprehension of the mechanism is still lacking. Here, X‐ray nanoanalysis is used, performed by simultaneous acquisition of X‐ray Fluorescence and X‐ray Beam Induced Current maps, to investigate at the nanoscale level the role of [6,6]‐phenyl‐C61‐butyric acid methyl ester fullerene (PCBM) molecules when interacting with MAPbI3 polycrystalline thin films acting as photo‐conductors in X‐ray detectors. At the device‐scale level it shows that the addition of PCBM enhances the X‐ray sensitivity by four times. At the nanoscale level how the perovskite grain boundaries act as high photocurrent generation centers is demonstrated. The addition of the PCBM increases the photocurrent generation, as the macroscopic performance does, and the charge collection becomes uniform over the full crystallite volume. The results clarify the role of grain boundaries and charge selecting layers and establish the X‐ray nanoanalysis techniques as a powerful tool to investigate charge transport and collection in perovskite films.
Safety and effectiveness of metabolic surgery in older Japanese patients
Authors: Takemoto Minoru , Hayashi Aiko , Inaba Yosuke , Tanaka Tomohiro , Chun Tae‐Hwa , Hayashi Hideki , Kasama Kazunori , Saiki Atsuhito , Sasaki Akira , Okazumi Shinichi , Matsubara Hisahiro , Tatsuno Ichiro
Published: May 2023

Aim

According to the current guidelines in Japan, the upper age limit for bariatric and metabolic surgery is 65 y. This study aimed to examine the appropriateness of this upper age limit.

Methods

Using the database maintained by the Japanese Society for Treatment of Obesity, we conducted an analysis of patients in two age groups: those aged <65 y and those aged ≥65 y. Our analysis focused on postoperative weight loss, improvement in comorbidities, and frequency of perioperative complications.

Results

A total of 2885 patients aged <65 y (mean, 43.9 ± 9.5 y) with a preoperative body mass index of 42.4 ± 8.1 kg/m2, while 56 aged ≥65 y (mean, 67.3 ± 3.2 y; maximum, 78 y) with a preoperative body mass index of 40.5 ± 6.6 kg/m2. Patients aged ≥65 y had a higher rate of dyslipidemia and hypertension. The rates of reoperation, surgical complications, and postoperative complications did not differ between the age groups. Both groups achieved significant weight loss postoperatively, and no differences in the improvement of comorbidities were noted. After adjusting the covariate balance via propensity score matching, no age‐related differences in perioperative and postoperative complications were observed.

Conclusion

Metabolic surgery is safe and effective for older patients with clinically severe obesity. Weight loss was less in patients aged ≥65 y, but the percentage of total weight loss did not differ between the groups.
Global rural health disparities in Alzheimer's disease and related dementias: State of the science
Authors: Wiese Lisa Ann Kirk , Gibson Allison , Guest Marc Aaron , Nelson Amy R. , Weaver Raven , Gupta Aditi , Carmichael Owen , Lewis Jordan P. , Lindauer Allison , Loi Samantha , Peterson Rachel , Radford Kylie , Rhodus Elizabeth K. , Wong Christina G. , Zuelsdorff Megan , Saidi Ladan Ghazi , Valdivieso‐Mora Esmeralda , Franzen Sanne , Pope Caitlin N. , Killian Timothy S. , Shrestha Hom L. , Heyn Patricia C. , Ng Ted Kheng Siang , Prusaczyk Beth , John Samantha , Kulshreshtha Ambar , Sheffler Julia L. , Besser Lilah , Daniel Valerie , Tolea Magdalena I. , Miller Justin , Musyimi Christine , Corkey Jon , Yank Veronica , Williams Christine L , Rahemi Zahra , Park JuYoung , Magzamen Sheryl , Newton Robert L. , Harrington Candace , Flatt Jason D. , Arora Sonakshi , Walter Sarah , Griffin Percy , Babulal Ganesh M.
Published: May 2023

INTRODUCTION

Individuals living in rural communities are at heightened risk for Alzheimer's disease and related dementias (ADRD), which parallels other persistent place‐based health disparities. Identifying multiple potentially modifiable risk factors specific to rural areas that contribute to ADRD is an essential first step in understanding the complex interplay between various barriers and facilitators.

METHODS

An interdisciplinary, international group of ADRD researchers convened to address the overarching question of: “What can be done to begin minimizing the rural health disparities that contribute uniquely to ADRD?” In this state of the science appraisal, we explore what is known about the biological, behavioral, sociocultural, and environmental influences on ADRD disparities in rural settings.

RESULTS

A range of individual, interpersonal, and community factors were identified, including strengths of rural residents in facilitating healthy aging lifestyle interventions.

DISCUSSION

A location dynamics model and ADRD‐focused future directions are offered for guiding rural practitioners, researchers, and policymakers in mitigating rural disparities.

HIGHLIGHTS

Rural residents face heightened Alzheimer's disease and related dementia (ADRD) risks and burdens due to health disparities.

Defining the unique rural barriers and facilitators to cognitive health yields insight.

The strengths and resilience of rural residents can mitigate ADRD‐related challenges.

A novel “location dynamics” model guides assessment of rural‐specific ADRD issues.