bluuebunny/crossref_metadata_2025 huggingface dataset:
Integrating Contemporary Art in the PYP IB Curriculum to Open Dialogues About Cultural Diversity in Norway
Authors: Balzi Leticia , Storlie Kristoffersen Cherise
Published: December 2020

What does it mean to open dialogues about cultural diversity using art in an international school in Norway? In the context of a changing Europe, cultural prejudices, sense of otherness as well as cultural and language barriers represent a challenge for educators. That is why, placing a special focus on progressive education, literacy and the humanities are key to designing a student-centered International Baccalaureate (IB) curriculum which is also inspired by the United Nations Sustainable Goals. What makes Norway’s private schools unique in comparison to other private schools that implement the IB curriculum is that a state-approved private school is 85% publicly financed. Within this context, Fagerhaug International School (in the region of Trondelag), has welcomed students coming from a wide variety of cultural and social backgrounds worldwide, and used art as a subject to integrate dissimilar cultures by opening dialogues about global issues, such as immigration. This means that many students in Norway can have access to quality public education within a multicultural environment whereby the community is enriched. The school can act as a cultural and political institution open to addressing local and global challenges to help shape a comprehensive model of the society. In this paper, three case studies are analyzed by using the theoretical approach of Diversity Pedagogy (Hernández Sheet, 2005) along with themes from theories related to democratic education (Freire, 2005). The article discusses the role of contemporary art in the teaching-learning process of art as a subject within Scandinavian socialism in the context of evolving Europe.
المسؤولية عن الأضرار الناتجة عن استخدام الطائرات بدون طيار " الدرون " في القوانين الداخلية و القانون الدولي
Authors: Marouf Shari Kh. , Aziz Yaseen M. , Khairullah Issa Kh.
Published: December 2020

ان موضوع بحثنا هو ( المسؤولية عن الاضرار الناتجة عن استخدام الطائرات بدون طيار "الدرون" في القوانين الداخلية والقانون الدولي) وقد درسنا فيه القوانين الداخلية فيما يتعلق بالمسؤولية عن استخدام هذا النوع من الطائرات التي بدون طيار،وقد اوجدنا نقاط التقاء المسؤولية الدولية عن استخدام هذه الطائرات في النزاعات المسلحة مع الاتفاقيات الدولية المنظمة لقواعد الحرب من خلال مقدمة في البحث عن تاريخ الطيران واهميته وخمسة مطالب، تناولنا في المطلب الاول ماهية الطائرة بدون طيار ، والثاني استخدامات الطائرة بدون طيار "الدرون" ، والثالث المسؤولية القانونية عن استخدام الطائرات بدون طيار في القانون الدولي ، والرابع المسؤولية القانونية عن استخدام الطائرات بدون طيار في القوانين الداخلية ، والخامس عن شروط الاعفاء من المسؤولية عن الاضرار الناتجة عن استخدام الطيارات بدون طيار، وفي الخاتمة اوردنا اهم الاستنتاجات والتوصيات ذات الصلة بالبحث ومنها سن نصوص قانونية خاصة في القوانين الداخلية تحدد ضوابط استخدام الطائرات المسيرة والاثار القانونية النترتبة على استخدامها وعدم ترك الموضوع للاجتهادات والقياس، ووضع اتفاقية دولية في اطار الامم المتحدة تنظم استخدام الطائرات المسيرة في حالات الحروب والنزاعات المسلحة.
How groundwater level can predict under the effect of climate change by using artificial neural networks of NARX
Authors:   Department of Water Resource Engineering, University of Birmingham, Edgbaston St., B152TT, UK, Javadinejad Safieh , Dara Rebwar ,   Department of Water Resource Engineering, University of Birmingham, Edgbaston St., B152TT, UK, Jafary Forough ,   Department of Water Resource Engineering, University of Birmingham, Edgbaston St., B152TT, UK
Published: December 2020

The phenomenon of climate change in recent years has led to significant changes in climatic elements and as a result the status of surface and groundwater resources, especially in arid and semi-arid regions, this issue has sometimes caused a significant decline in groundwater resources. In this paper, the effects of climate change on the status of groundwater resources in Marvdasht plain have been investigated. Water supply of different parts of this region is highly dependent on groundwater resources and therefore the study of groundwater changes in future periods is important in the development of this plain and the management of its water resources. In order to evaluate the effects of climate change, the output of atmospheric circulation models (GCM) has been used. Then, in order to adapt the output scale of these models to the scale required by local studies of climate change, precipitation and temperature data have been downscaled by LARS-WG model. Downscaled information was used to determine the amount of feed and drainage of the aquifer in future periods. To investigate changes in groundwater levels at different stages, a neural network dynamic model has been developed in MATLAB software environment. It is also possible to study and compare other points using other scenarios and mathematical modeling. The results of the study, assuming the current state of development in the region, indicate a downward trend in the volume of the aquifer due to climate change and its effects on resources and uses of the study area. The results also introduce Scenario A2 as the most critical scenario related to climate change, which also shows the largest aquifer decline in neural network modeling.
Impact of resistance to fenitrothion and esfenvalerate on the control of Rhyzopertha dominica (Coleoptera: Bostrichidae) in stored wheat
Authors: Vásquez-Castro Javier Alberto , De Baptista Gilberto Casadei , Gadanha Jr. Casimiro Dias , Bracho-Pérez Julio Cesar
Published: December 2020

Insecticides resistance can significantly compromise the control programs of Rhyzopertha dominica (Coleoptera: Bostrichidae), one of the main wheat pests in warehouses. The objectives of this work were to study the occurrence of resistance to fenitrothion and esfenvalerate in two Brazilian populations of R. dominica from Santa Rosa (SR lineage) and Campo Grande (CG lineage), as well as the insecticidal effect and residual action of these insecticides when used alone or as a mixture in stored wheat. The application system was calibrated to provide grain treatment at theoretical concentrations of 10 and/or 0.5 mg kg-1 fenitrothion and esfenvalerate, respectively. By comparing the fitted mortality curves for lineages within insecticides, as well as insecticides within lineages significant differences were observed in all cases. Esfenvalerate was ineffective in controlling R. dominica. The SR lineage of R. dominica was more resistant to the insecticides tested than the CG lineage. The number of individuals in the F1 offspring of R. dominica was dependent on the lineage, insecticide, and on the time after the application of insecticide. In the untreated grains (control), the CG lineage had a greater number of progeny than the SR lineage, while the opposite was verified in the grains treated. Fenitrothion and esfenvalerate are not useful for the control of R. dominica. Factors influencing control of R. dominica are discussed in this work.
Retratos de um derrotado: Xerxes, o “Grande Rei”
Authors: Dos Santos Ricardo Neves
Published: December 2020

Aristóteles relaciona poesia dramática à pintura em algumas passagens de sua Poética. Com base nessa relação, este artigo busca argumentar que o termo “retrato”, comum às artes plásticas, também poderia ser útil na análise de aspectos presentes no teatro antigo, principalmente no que se refere à caracterização de seus personagens. Para exemplificar essa proposta, a figura de Xerxes, personagem presente tanto no trabalho historiográfico de Heródoto como na tragédia de Ésquilo, Os Persas, é trazida à discussão.
A misoginia na tradição biográfica de Eurípides
Authors: De Moura Camila
Published: December 2020

Eurípides, entre os três tragediógrafos canônicos da Grécia clássica, é aquele de quem a Antiguidade nos legou maior quantidade de material biográfico. Percorrendo esse material, nota-se a persistente caracterização do poeta como misógino (μισογύνης). A palavra figura em dois dos textos biográficos mais importantes em torno do poeta (a Vida anônima anexada aos manuscritos medievais de sua obra e o verbete do Suda), e sua “aversão às mulheres” é aludida direta ou indiretamente em todas as Vidas que chegaram aos nossos dias. Este artigo apresentará essas ocorrências e buscará analisá-las à luz da comédia de Aristófanes, propondo uma articulação entre as paradoxais recepções da obra do poeta na Antiguidade e na modernidade, quando será construída a imagem de um Eurípides “feminista”.
Artificial Unity in Scandal Mentality
Authors: Câmara Clara , Roxo da Silva Marco Antonio
Published: December 2020

In this article we reflect on some of the narrative strategies used to structure political scandals. In order to do this we conceive political scandals in journalism as a mentality. The narrative strategies contained in this mentality help toward understanding these events, which we perceive as scandals. We shall present three of these strategies contained in what we call “artificial unity”, which transmit to readers the idea that there is endless and uniform narratives on scandals. Using both critical analysis of narrative and the indiciary paradigm, we focus our reflections on a number of scandals which occurred while the Workers’ Party (PT) government was in power, as they were reported in the O Globo newspaper.Neste artigo, propomos refletir sobre algumas das estratégias narrativas que estruturam a ideia de escândalo político. Para isso, propomos conceber os escândalos políticos, no jornalismo, como uma mentalidade. É essa mentalidade que resguarda estratégias narrativas que auxiliam na compreensão desses acontecimentos, que são concebidos como escândalos. Aqui, focamos em apresentar três dessas estratégias, contidas no que chamamos de “unidade artificial”, e que oferecem ao leitor uma ideia de que há uma grande narrativa de escândalo, uniforme e infindável. Unindo pressupostos da Análise crítica de narrativa e do paradigma indiciário, focamos nossas reflexões na listagem de escândalos dos governos do Partido dos Trabalhadores (PT), feita pelo jornal O Globo. En este artículo, proponemos reflexionar sobre algunas de las estrategias narrativas que estructuran la idea del escándalo político. Para eso, proponemos concebir los escándalos políticos, en el periodismo, como una mentalidad. Es esta mentalidad la que protege las estrategias narrativas que ayudan a comprender estos eventos, que se conciben como escándalos. Aquí, nos enfocamos en presentar tres de estas estrategias, contenidas en lo que llamamos "unidad artificial", y que ofrecen al lector una idea de que hay una gran narrativa de escándalo, uniforme e interminable. Uniendo los supuestos del análisis crítico de la narrativa y el paradigma indicativo, centramos nuestras reflexiones en la lista de escándalos de los gobiernos del Partido de los Trabajadores (PT), realizada por el periódico O Globo.
Interventionist performs a “sham” lumbar microdiscectomy: Should interventionalists be performing spinal surgery?
Authors: Ghaly Ramsis F. , Perciuleac Zinaida , Candido Kenneth D. , Knezevic Nebojsa Nick
Published: December 2020

Background:

Neurosurgeons and orthopedists, who have received specific training, should be the ones performing spinal surgery. Here, we present a case in which spinal surgeons secondarily (e.g., 6 months later) found that a patient’s first lumbar discectomy, performed by an interventional specialist, had been a “sham” procedure.

Case Description:

A 30-year-old male presented with sciatica attributed to a magnetic resonance imaging documented large, extruded disc at the L4-5 level. An interventional pain management specialist (IPMS) performed two epidural steroid injections; these resulted in an exacerbation of his pain. The IPMS then advised the patient that he was a surgeon and performed an “interventional” microdiscectomy. Secondarily, 6 months later, when the patient presented to a spinal neurosurgeon with a progressive cauda equina syndrome, the patient underwent a bilateral laminoforaminotomy and L4-L5 microdiscectomy. Of interest, at surgery, there was no evidence of scarring from the IPMS’ prior “microdiscectomy;” it had been a “sham” operation. Following the second surgery, the patient’s cauda equina syndrome resolved.

Conclusion:

IMPS, who are not trained as spinal surgeons should not be performing spinal surgery/ microdiscectomy.
Nonconvulsive status epilepticus associated with Alzheimer’s disease mimicking symptomatic focal epilepsy following the resection of a frontal parasagittal meningioma
Authors: Abe Keisuke , Mukae Nobutaka , Morioka Takato , Sangatsuda Yuhei , Sakata Ayumi , Suzuki Satoshi O. , Mizoguchi Masahiro
Published: December 2020

Background:

Epilepsies are frequent in patients with Alzheimer’s disease (AD); however, epilepsies in AD can easily go unrecognized because they usually present as focal impaired awareness seizures or nonconvulsive status epilepticus (NCSE) and can overlap with other symptoms of AD.

Case Description:

We performed an epilepsy surgery in a 69-year-old woman with progressive cognitive impairment and consciousness disorder, who was diagnosed with focal NCSE related to the resected meningioma in the right frontal parasagittal region. Intraoperative electrocorticography revealed localized periodic paroxysmal discharges with beta and gamma activities in the neighboring cortex where the meningioma existed. The histopathological diagnosis of AD was first made from the resected epileptogenic cortex.

Conclusion:

Even when there is a suspected epileptogenic lesion that could cause focal NCSE, AD should be ruled out in elderly patients with progressive cognitive decline.
Management dilemma of tuberculous paraplegia in pregnancy – A case report and review of literature
Authors: Srivastava Sudhir , Raj Aditya , Agarwal Rishi , Bhosale Sunil , Marathe Nandan
Published: December 2020

Background:

Tuberculosis (TB)/tuberculous spondylodiscitis of the spine causing paraplegia in the 2nd trimester of pregnancy is rare and poses significant management dilemmas. Pregnancy, a relatively immunocompromised state with high hormonal levels, may prompt rapid TB destruction of a vertebral body resulting in an acute/ profound neurological deficit. Here, a pregnant paraplegic mother was diagnosed with spondylodiscitis that warranted immediate decompression/fusion to achieve neurological recovery.

Case Description:

A 26-year-old female was 23 weeks pregnant when she presented with an acute spastic paraplegia (complete motor, sensory deficit, and sphincter loss). Operative decompression utilized a Versatile Approach along with a “Hartshill rectangle” for fusion and sublaminar wiring. This procedure accomplished simultaneous anterior and posterior fixation with a single approach without the need for intraoperative radiologic imaging. Although the pregnancy was continued with an uneventful perioperative period, intra-uterine fetal demise was documented 1 month postoperatively. Within 18 postoperative months the patient was neurologically intact, and fusion was confirmed on a computed tomography scan.

Conclusion:

A 23-week pregnant female acutely became paraplegic due to T5 tuberculous spondylitis confirmed on an X-ray (only source of radiation), and magnetic resonance imaging. Following a decompression/ instrumented fusion performed without fluoroscopic guidance, the patient regained full neurological function. However, 1 month postoperatively, the fetus spontaneously aborted.
Successful balloon-assisted coil embolization for a diagnostically difficult case of spontaneous vertebrovertebral arteriovenous fistula
Authors: Mizuhashi Satomi , Kominami Shushi , Fukuda Kazumasa
Published: December 2020

Background:

We describe a rare case of idiopathic lower cervical vertebro-vertebral arteriovenous fistula (VVAVF) with compression of the nerve roots and spinal cord, successfully treated with detachable coils utilizing the transarterial balloon-assisted technique without complication of coil mass.

Case Description:

A 68-year-old woman was admitted for numbness of the left upper limb and pain in the left neck. Cervical magnetic resonance imaging (MRI) revealed compression of nerve roots and spinal cord by a large vascular lesion. The left vertebral angiography demonstrated a VVAVF draining into the vertebral venous plexus at C5 level. Under general anesthesia, the fistula site was accessed with a microcatheter through the right femoral artery, and successful embolization performed by compactly placing several detachable coils using balloon-assisted technique. The patient made a full recovery, with long-term MRI-documented left vertebral artery patency and no fistular leakage, and without postoperative complications.

Conclusion:

Target occlusion utilizing the balloon-assisted technique in this case of VVAVF with compression of nerve roots and spinal cord, was effective in improving neurological symptoms, and achieved long-term occlusion when preservation of the VA was desired.
Preliminary development of a deep learning-based automated primary headache diagnosis model using Japanese natural language processing of medical questionnaire
Authors: Katsuki Masahito , Narita Norio , Matsumori Yasuhiko , Ishida Naoya , Watanabe Ohmi , Cai Siqi , Tominaga Teiji
Published: December 2020

Background:

Primary headaches are widespread and costly public health problems. However, there are insufficient medical resources for their treatment in Japan due to two reasons. First, the numbers of headache specialists and clinics remain insufficient. Second, neurologists and neurosurgeons mainly treat headaches in Japan. However, they mainly work as general stroke neurologists, so they cannot focus on primary headache treatment. To solve these problems, we preliminarily developed a deep learning (DL)-based automated diagnosis model from patients’ Japanese unstructured sentences in the medical questionnaire using a DL framework. We hypothesized that the model would reduce the time and burden on both doctors and patients and improve their quality of life.

Methods:

We retrospectively investigated our primary headache database and developed a diagnosis model using the DL framework (Prediction One, Sony Network Communications Inc., Japan). We used age, sex, date, and embedding layer made by the medical questionnaire’s natural language processing (NLP).

Results:

Eight hundred and forty-eight primary headache patients (495 women and 353 men) are included. The median (interquartile range) age was 59 (40–74). Migraine accounted for 46%, tension-type headache for 47%, trigeminal autonomic cephalalgias for 5%, and other primary headache disorders for 2%. The accuracy, mean precision, mean recall, and mean F value of the developed diagnosis model were 0.7759, 0.8537, 0.6086, and 0.6353, which were satisfactory.

Conclusion:

The DL-based diagnosis model for primary headaches using the raw medical questionnaire’s Japanese NLP would be useful in performing efficient medical practice after ruling out the secondary headaches.
A new approach to treatment of stomatitis in experiments on white rats (experimental research)
Authors: Ганина Е.Б. , Червинец Ю.В. , Грудинин Н.В. , Шестакова В.Г. , Червинец В.М. , Миронов А.Ю.
Published: December 2020

Цель исследования - охарактеризовать микробиологическую картину стоматита до и после его лечения высокоактивными культурами лактобацилл, дать оценку эффективности их применения при экспериментальном стоматите. Методика. Опыты проводились на 32 самках беспородных белых крыс массой 230 г. Моделирование стоматита включало 2 этапа: моделирование травматического стоматита и воспроизведение бактериального стоматита на базе травматического. У крыс контрольной и опытных серий на всех этапах эксперимента брали мазки с поверхности десен для характеристики микробиоценоза ротовой полости. Результаты. После обработки слизистой оболочки полости рта (СОПР) культурой патогенного штамма Staphylococcus aureus существенно снизились частота встречаемости и количество условно-патогенных микроорганизмов. Лечение стоматита у крыс культурами лактобацилл ( Lactobacillus 11 зв., Lactobacillus 2 п.рта, Lactobacillus 24 д.ст.) и их комбинацией приводило к снижению распространенности S. aureus вплоть до его исчезновения, а также к нормализации количества условно-патогенной микробиоты. Заключение. Исследования показали эффективность использования отдельных высокоактивных штаммов лактобацилл или их комбинации при лечении заболеваний СОПР, в частности бактериального стоматита.

Aim. To characterize the microbiological picture of stomatitis in intact rats before and after the treatment with highly active cultured lactobacilli and to evaluate the effectiveness of this treatment in experiments on white rats. Methods. Experiments were carried out on 32 mongrel female white rats weighing 230 g. Smears were taken from the gum surface of control and experimental rats at all stages of the experiment to characterize the oral cavity microbiocenosis. Results. After treatment of the oral cavity with cultured Staphylococcus aureus , the occurrence and quantity of opportunistic microorganisms significantly decreased. The treatment of stomatitis in rats with cultured lactobacillus ( Lactobacillus 11 zv., Lactobacillus 2 p.r., Lactobacillus 24 d.st. and their combination) led to a decrease in S. aureus prevalence up to its extinction and to normalization of the quantitative composition of opportunistic microbiota. Conclusions. The study showed the effieacy of highly active lactobacillus strains individually or their combinations in the treatment of oral diseases, in particular, bacterial stomatitis.
Hyperhomocysteinemia and chronic kidney disease
Authors: Круглова М.П. , Иванов А.В. , Введенская О.Ю. , Кубатиев А.А.
Published: December 2020

Гипергомоцистеинемия (ННсу) является независимым фактором риска развития сердечно-сосудистых осложнений, а также непосредственной причиной ренальных повреждений у пациентов с хронической болезнью почек (ХБП). В данном обзоре рассмотрены возможные механизмы нарушения метаболизма гомоцистеина (Нсу) при ХБП, а также молекулярные и клеточные механизмы повреждений, опосредованных гипергомоцистеинемией (ННсу)

Hyperhomocysteinemia (HHcy) is an independent risk factor for cardiovascular disease and the direct cause of renal injury in patients with chronic kidney disease (CKD). This review considers the potential mechanisms of homocysteine (Hcy) metabolism disorders, and pathogenesis of molecular and cellular damage mediated by hyperhomocysteinemia (ННсу)
Neurobiological predisposition to addictive disorders. Antibodies to neurotransmitters
Authors: Давыдова Т.В. , Невидимова Т.И. , Ветрилэ Л.А. , Захарова И.А. , Савочкина Д.Н. , Бохан Н.А.
Published: December 2020

Выявление нейробиологической предрасположенности к развитию аддиктивных расстройств является актуальной задачей при решении проблемы профилактики болезней зависимости от психоактивных веществ. Ключевую роль в разработке этой проблемы играет изучение молекулярных нейроиммунных механизмов регуляции нейромедиации в развитии аддиктивных расстройств. Целью работы было изучение в сыворотке крови иммуноферментным методом содержания аутоантител к нейромедиаторам для построения паттерна их изменения при формировании зависимости к психоактивным веществам. Показано, что система антител к дофамину, норадреналину, глутамату изменяется в процессе развития зависимости от психоактивных веществ и может рассматриваться в качестве нейроиммунного маркера для выявления групп риска развития наркомании.

Identification of neurobiological susceptibility to addictive disorders is an important issue of preventing psychoactive substance dependence. A key role in approaching this issue belongs to studying molecular neuroimmune mechanisms for neurotransmission regulation during development of addictive disorders. The aim of this study was to construct a pattern of changes in serum neurotransmitter autoantibodies during formation of psychoactive substance dependence using immunoassay. The system of antibodies to dopamine, norepinephrine, and glutamate changed during the development of psychoactive substance dependence and can be considered as a neuroimmune marker for identifying groups at risk of drug addiction.
Preventive phototherapy in the blue range of optical radiation in preparation for underwater activities
Authors: Карганов М.Ю. , Панкова Н.Б. , Карандашов В.И. , Черепов А.Б.
Published: December 2020

Исследовали эффекты профилактического оптического излучения в синем диапазоне в течение четырех недель на функциональное состояние кардио-респираторной системы человека. При тестировании использовали нагрузочные пробы. Эффекты фототерапии проявились в отсутствии изменений ряда показателей сердечно-сосудистой системы, характерных для периода максимального прироста светового дня.

Effects of preventive optical radiation in the blue range on the functional state of the human cardiorespiratory system were studied for four weeks using loading tests. The effects of phototherapy were evident as the absence of changes in several cardiovascular indexes characteristic for the period of maximum increase in daylight hours.
Plasma low molecular weight aminothiols in patients with acute ischemic stroke
Authors: Максимова М.Ю. , Булгакова П.О. , Иванов А.В. , Вирюс Э.Д. , Александрин В.В. , Никифорова К.А. , Охтова Ф.Р. , Суанова Е.Т. , Пирадов М.А. , Кубатиев А.А.
Published: December 2020

Цель: оценить гомеостаз низкомолекулярных аминотиолов (цистеина, цистеинил-глицина, гомоцистеина и глутатиона) в плазме крови в остром периоде ишемического инсульта. Методика. Обследован 41 пациент с атеротромботическим и кардиогенным эмболическим инсультом. 31 пациент с хронической ишемией головного мозга был включен в контрольную группу. Общий уровень низкомолекулярных аминотиолов и уровни их восстановленных форм определяли в 1-е, 3-и, 7-е и 15-е сут. инсульта. Результаты. Уровни восстановленных форм цистеина и цистеинил-глицина у больных с инсультом были снижены в 1-е-7-е сут. инсульта. Наблюдалось раннее повышение общего содержания глутатиона и цистеина, носящее, по всей видимости, адаптивный характер. Различий между уровнями низкомолекулярных аминотиолов у пациентов с атеротромботическим и кардиогенным подтипами инсульта выявлено не было. Анализ логистической регрессии показал, что исходные уровни восстановленного гомоцистеина, общего цистеинил-глицина и редокс-статус цистеина у пациентов являлись прогностическими факторами возникновения атеротромботического и кардиогенного эмболического инсульта с вероятностью 86,2% (р <0,001). Выводы. Уровни низкомолекулярных аминотиолов ассоциируются с тяжестью неврологических нарушений и объемом инфарктов головного мозга. Их определение может иметь диагностическое значение как в острейшем периоде ишемического инсульта, так и при мониторинге его течения.

Objectives: To evaluate homeostatic disorders of plasma low molecular weight aminothiols (LMWTs: cysteine, cysteinylglycine, homocysteine, and glutathione) during acute and early subacute stages of ischemic stroke. Patients and Methods: 41 patients with primary large-artery atherosclerosis and cardioembolic stroke were admitted within the first 6-24 h of the onset of neurologic symptoms. The control group included 31 patients with chronic cerebral ischemia. Concentrations of total LMWTs and their reduced forms were measured on days 1, 3, 7, and 15 after stroke. Results and Discussion: Concentrations of cysteine and cysteinylglycine reduced forms were decreased in patients with stroke on days 1-7. Also, early adaptive increases in total glutathione and cysteine levels were observed. LMWT concentrations did not differ between stroke subtypes. The analysis of logistic regression indicated that concentrations of reduced homocysteine and total cysteinylglycine and the redox status of cysteine at admission were predictive factors for development of ischemic stroke with a probability of 86.2% (p < 0.001). Conclusion: Concentrations of LMWTs may indicate the severity of neurological deficit and the size of cerebral infarct. Measuring these concentrations can be diagnostically important both at an early stage of ischemic stroke and during stroke monitoring.
Activities of regulatory RNAs that affect development of tumor cells in patients with laryngeal cancer
Authors: Салеева Д.В. , Михайлов В.Ф. , Шуленина Л.В. , Виноградов В.В. , Бахтин А.А. , Акопян К.В. , Незнанова М.В. , Засухина Г.Д.
Published: December 2020

Цель. Определение прогностической значимости и роли экспрессии некодирующих РНК (длинные РНК и микроРНК), и белка кодирующих генов в патогенезе рака гортани. Методика. Исследован биопсийный материал и периферическая кровь 35 пациентов с диагнозом плоскоклеточный рак гортани (ПРГ) с классификацией от T1N0M0 до T4N1M0. Контролем служили образцы близлежащей гистологически неизмененной ткани гортани тех же больных. Для оценки экспрессии генов исследовали кровь 27 здоровых доноров. Содержание мРНК генов ( р53, CCND1, ORAOV1, hPTEN ), длинных некодирующих РНК (днРНК): NEAT1, MALAT1, ROR , а также зрелых микроРНК (miR-21, miR-27a, miR-34a, miR-101, miR-124, miR-125b, miR-181а) в опухолевой ткани и крови определяли методом ПЦР в реальном времени (ПЦР-РВ). Результаты. Выявлено увеличение содержания мРНК генов CCND1, hPTEN , днРНК NEAT1, MALAT1 и miR-21, miR-27a в крови у пациентов с ПРГ. Установлено, что уровень мРНК генов CCND1, ORAOV1 был значимо выше при исследовании биоптатов у больных 3-й - 4-й стадии, чем у больных 1-й - 2-й стадии заболевания. Такая же закономерность выявлена для днРНК NEAT1, MALAT1 и для miR-101. Экспрессия miR-27a и miR-124 на более поздних стадиях болезни была ниже, чем у пациентов 1-2 стадии. Заключение. Выявлена возможность использования исследованных днРНК, микроРНК и мРНК белоккодирующих генов для индивидуального прогноза заболевания при создании панели биомаркеров.

Aim. To study the role of non-coding RNA (long RNAs and microRNAs) expression and protein-coding genes in the pathogenesis of laryngeal cancer to determine their prognostic significance for oncotransformation. Methods. The expression of long non-coding RNAs, microRNAs and protein-coding genes was examined in biopsy samples (fresh frozen tissue) and peripheral blood samples from 35 patients with laryngeal squamous cell cancer (LSCC) at T1N0M0 - T4N1M0 stages. Samples of surrounding, histologically unchanged tissues collected from the same patients were used as control. Gene expression was evaluated in blood samples from 27 healthy donors. Contents of gene mRNAs ( p53, CCND1, ORAOV1, hPTEN ), long non-coding RNAs (IncRNA) ( NEAT1, MALAT1, ROR ), and mature miRNAs (miR-21, miR-27a, miR-34a, miR-101, miR-124, miR -125b, miR-181a) were measured in tissue and blood using real-time PCR. Results. Contents of CCND1 and hPTEN gene mRNAs, lncRNAs ( NEAT1, MALAT1), miR-21, and miR-27a were increased in blood of patients with LSCC. Levels of CCND1 and ORAOV1 gene mRNAs were significantly higher in biopsy samples from stage 3-4 patients compared to stage 1-2 patients. A similar expression pattern was observed for lncRNAs NEAT1 and MALAT1 and miR-101. On the other hand, expression of miR-27a and miR-124 was lower at later stages than at stages 1-2. Conclusion. The studied lncRNAs, microRNAs and protein-coding genes can be used in development of a biomarker panel for individual prognosis of the disease.
Platelet apoptosis and phenotype in patients with acute ischemic stroke
Authors: Соколовская А.А. , Максимова М.Ю. , Вирюс Э.Д. , Московцев А.А. , Иванов А.В. , Александрин А.А. , Кубатиев А.А.
Published: December 2020

Aim. To develop of knowledge of platelet apoptosis and phenotype in patients with acute ischemic stroke and to study the prognostic value of some membrane-bound proteins. Method. The study included 18 patients aged 59-78 with acute ischemic stroke. Platelet were isolated by immonomagnetic separation within the first 24 hours and at 7 days of ischemic stroke. The expression of surface antigens was measured using monoclonal antibodies. For detection of phosphatidylserine (PS) externalization platelets were incubated with Annexin V. The mitochondrial membrane potential (MMP) was measured using JC-1 during platelets apoptosis. Immediately after the incubation, platelets were analyzed by flow cytometry. Results. On day 1 of stroke, the expression of CD62p (P-selectin) was higher than in healthy subjects (18.3% vs . 4.1%, respectively, p<0.05). The PS externalization on platelets from patients with stroke was significantly higher than in healthy subjects (20.6% vs. 3.2%, respectively, p<0.01). A decrease in MMP to 70% was observed in platelets from patients with stroke compared to 94% in the control group (p<0.05). Conclusion. Therefore, acute ischemic stroke was associated with the following platelet abnormalities: increased PS expression and declined MMP in parallel with increased P-selectin expression, which reflects platelet activation. Further studies of platelet phenotype and apoptosis biomarkers will provide a deeper insight into the pathogenetic role of platelets in ischemic stroke and contribute to the development of methods for monitoring effects of antiplatelet therapy.
Effects of fibrinogen concentrate, factor XIII, and thrombin-activatable fibrinolysis inhibitor on clot firmness and fibrinolytic resistance in the model of hyperfibrinolysis
Authors: Будник И.А. , Морозова О.Л. , Цымбал А.А. , Шенкман Б. , Эйнав Ю.
Published: December 2020

Цель исследования - изучение возможности коррекции формирования кровяного сгустка и его фибринолитической устойчивости с помощью концентратов фибриногена, фактора XIII и активируемого тромбином ингибитора фибринолиза (TAFI) в модели гиперфибринолиза in vitro . Методика. В образцы цитратной крови, полученной от 24 взрослых здоровых добровольцев, добавляли концентрат фибриногена, фактора XIII и/или TAFI. Фибринолиз индуцировали добавлением тканевого активатора плазминогена. Свертывание крови индуцировали рекальцификацией и добавлением препарата тканевого фактора. Формирование и лизис сгустка изучали методом ротационной тромбоэластометрии. Результаты. Индукция фибринолиза не влияла на время свертывания и скорость формирования сгустка, но значительно уменьшала максимальную плотность сгустка и вызывала его лизис. Концентрат фибриногена замедлял скорость лизиса сгустка; концентрат фактора XIII усиливал механическую прочность сгустка и замедлял скорость его лизиса, не влияя при этом на время начала лизиса; TAFI усиливал механическую прочность и значительно отдалял время начала лизиса, оказывая тем самым наибольший корригирующий эффект. Заключение. Полученные данные демонстрируют потенциальную возможность коррекции гемостатического потенциала крови при гиперфибринолизе с помощью концентратов фибриногена, фактора XIII и TAFI, которые могут стать альтернативой традиционным антифибринолитикам.

Aim. To investigate effects of fibrinogen concentrate, factor XIII, and thrombin-activatable fibrinolysis inhibitor (TAFI) on clot formation and fibrinolytic resistance using an in vitro model of hyperfibrinolysis. Methods. Citrated whole blood from 24 adult healthy volunteers was supplemented with fibrinogen concentrate, factor XIII, and/or TAFI. Fibrinolysis was induced by tissue plasminogen activator. Clotting was induced by recalcification and addition of tissue factor and monitored using rotation thromboelastometry. Results. Induction of fibrinolysis did not affect clotting time and the rate of clot formation but significantly reduced the maximum clot firmness and caused lysis of a clot. Addition of fibrinogen concentrate to blood reduced the rate of clot lysis without affecting clot firmness or lysis onset time; addition of factor XIII improved clot firmness and reduced clot lysis rate without affecting lysis onset time; TAFI improved clot firmness and considerably delayed the onset of clot lysis thereby providing the greatest antifibrinolytic effect. Conclusion. Fibrinogen concentrate, factor XIII, and TAFI may potentially serve as an alternative to traditional antifibrinolytic agents and be beneficial for the treatment of patients with hyperfibrinolysis.
A review article on home remedies during COVID-19 pandemic lockdown
Authors: Anagha Hirapure  , Saurabh Deshmukh  , Shweta Parwe
Published: December 2020

Coronaviruses are the group of new viruses that have been endangered in animals and humans in the year November 2019. There are 6 types of coronaviruses which has been known to infect human and form a host factor. Out of 6 types of coronaviruses 229E, NL63, OC43, HKU, are responsible for causing symptoms from mild to moderate whereas MERS-CoV & SARS-CoV is of zoonotic which cause the symptoms from moderate to severe, where it affects the human respiratory system which causes difficulty in breathing. The specific treatment is yet to come but to get relief from the symptom of the disease. One has to improve own immune system so as to fight the viral fever, dry cough, and other symptoms by practising the use of some herbal home ingredients and home remedies so as to boost up the immunity. This review article mostly focused on the covid-19 pandemic, drastic information about coronavirus and the preventive measures to boost up the immunity by home-made herbal ingredients so as to prevent COVID-19 spread. The main aim of the article is to inform about the ingredients which are present at home and can be used in order to make herbal remedies for boosting up the immunity power. The immune system plays an important role in fighting the virus by creating antibodies against the viral infection. This article is based on the homemade immune boosters.
Coronavirus - Past and Present
Authors: Alfiya Qamar
Published: December 2020

Coronavirus infectious disease 2019 (COVID-19) caused by a new mutant strain of coronavirus (SARS-CoV-2) which is an ongoing global health pandemic. However, you'll have first become conversant in the term coronavirus during the severe acute respiratory syndrome (SARS) outbreak in 2002. Here we summarize important distinguishing characteristics concerning both SARS-CoV and SARS-CoV2. SARS-Cov2, which is caused by the new novel coronavirus, has been highlighting the news lately. The virus that causes SARS is entitled as SARS-CoV, while the virus that causes COVID-19 is entitled as SARS-CoV-2. SARS was declared a global pandemic in late 2002 in China, when a healthcare practitioner got infected with a virus and unknowingly travelled to Hong Kong, with rapid spread to other nearby countries by international travelling of people. But due to many other factors, SARS was restrained in around 30 countries with an estimated mortality rate of 10% by the end of the pandemic in mid-2003. The focal point of this current novel coronavirus outbreak is within Wuhan city of China. Animal host act as a reservoir for novel coronavirus and it can infect human by crossing this barrier. Hence, a seafood wholesale market in the city was thought to be one among the places from where the transmission of COVID-19 initiated. As we go further in this article, we will come across the differences in genomic structure, pathogenicity, clinical features and lab investigations among SARS-CoV2 and SARS-CoV.
Nilai Dasar Collaborative Governance Dalam Studi Kebijakan Publik
Authors: Nasrulhaq Nasrulhaq
Published: December 2020

This paper examines the basic values of collaborative governance based on theoretical studies and empirical facts in an integrative manner. The starting point study of the relationship between stakeholders in each stage of public policy is increasingly complex. Based on this complexity, studies on governance also experience dynamics. The collaborative framework in governance provides a meaning that is more than just governance. Collaborative governance is a concept in public policy that has developed in the last few decades. In principle, the collaborative is different from the network as well as the partnership. There is an essential value attached to it. Henceforth, it becomes part of its characteristics. The basic values referred to are consensus orientation, collective leadership, multidirectional communication, and resource sharing. The four basic values are integrated into one integrated process in any collaborative governance action.
Restrukturisasi Organisasi dan Kualitas Pelayanan di Dinas Penanaman Modal Pelayanan Terpadu Satu Pintu Kota Makassar
Authors: Darwis Darwis , Haning Mohamad Thahir , Indar Nur Indrayati Nur
Published: December 2020

This study aims to determine the Organizational Restructuring and Service Quality in the One-Stop Integrated Service Investment Service in Makassar City. The type of research in this research is quantitative with a descriptive style. The population in this study are all people who take care of permits at DPMPTSP Makassar City. The sample in this study amounted to 75 people. The data collecting technique in this research is using a questionnaire. Then the collected data were analyzed descriptively quantitatively. This study's results indicate that the variable of organizational restructuring includes the complexity of 62.3, formalization of 62.2, and centralization of 61.9. Meanwhile, service quality variables include reliability 61.26, tangible 66.13, responsiveness 62.26, Assurance 58.53, and empathy 62.4.
ADOÇÃO HOMOPARENTAL, MELHOR INTERESSE DA CRIANÇA E RELAÇÕES DE PODER: UMA ANÁLISE A PARTIR DA TEORIA DE MICHEL FOUCAULT
Authors: GALEÃO DE AZEVEDO THIAGO AUGUSTO , MATOS LORENA ARAÚJO
Published: December 2020

Trata-se de um estudo sobre a adoção homoparental à luz da teoria de Michel Foucault, mais especificamente da sua ideia de dispositivo de sexualidade. Busca-se compreender as concepções subjacentes ao questionamento da adoção homoparental poder representar o melhor interesse da criança, em uma situação concreta. Para tanto, inicialmente, expõe-se o princípio do melhor interesse da criança, seguido de uma explanação sobre a teoria de Michel Foucault e seu dispositivo de sexualidade. E, em um terceiro momento, a partir da construção teórica crítica construída analisar a adoção homoparental no ordenamento jurídico pátrio.
O ACESSO À INFORMAÇÃO COMO INSTRUMENTO À EDUCAÇÃO INCLUSIVA: UM OLHAR A PARTIR DO DESENVOLVIMENTO SUSTENTÁVEL
Authors: Lazaretti Isadora , Both Voos Yana Paula , Stecanella Elouise Mileni
Published: December 2020

O presente trabalho tem como tema central os direitos fundamentais no que se refere ao acesso à informação como instrumento à educação inclusiva, a partir da perspectiva da Agenda 2030 da Organização das Nações Unidas (ONU).  Para tanto, fora proposta uma análise acerca da Agenda 2030, bem como um estudo bibliográfico sobre o direito humano fundamental ao acesso à informação e seu impacto na educação. A pesquisa utilizou a técnica de pesquisa bibliográfica, por sua natureza exploratória, por meio da utilização de artigos da base de dados da CAPES, além da legislação brasileira, documentos internacionais oficiais e outros artigos e obras sobre a temática.
A COMPLEXIDADE DO RACISMO ESTRUTURAL: REDUÇÃO DE TRABALHADORES À CONDIÇÃO ANÁLOGA A DE ESCRAVOS COMO CONTINUÍSMO DO SISTEMA ECONÔMICO ESCRAVOCRATA
Authors: Correa de Melo Herena Neves Maues
Published: December 2020

O objetivo é discernir as bases do racismo estrutural no Brasil, a fim de compreendermos porque o trabalho escravo contemporâneo no Brasil deve ser enfrentado a partir desta lógica, no escopo de que se sua mitigação ocorra de forma sustentável. A metodologia é de caráter qualitativo e exploratório, a partir das nuances da revisão bibliográfica e documental. Percebe-se o racismo estrutural como a fonte causal da normalização da prática de reduzir trabalhadores à condição análoga a de escravos e da reprodução e florescimento da prática, havendo a necessidade de modificação escalonada de ações que envolvam políticas públicas institucionais e educacionais.
VEDAÇÃO AO RETROCESSO EM DIREITOS TRABALHISTAS: UMA ABORDAGEM SOBRE A TERCEIRIZAÇÃO E SEUS IMPACTOS
Authors: Borges Nathaly Giunta , Striquer Soares Marcos Antonio , Wasilewski Rodrigues Tatiana Kolly
Published: December 2020

O trabalho abordou aspectos da recente reforma trabalhista, que trouxe um grande retrocesso social no que se trata da incompatibilidade com os princípios base do Estado Democrático de Direito. A investigação questiona se a reforma trabalhista pode ser encarada como retrocesso social, limitadora de direitos e garantias ante os direitos já conquistados pelos trabalhadores. O método utilizado foi à pesquisa bibliográfica contida em diversos autores renomados que abordam o tema buscando por fim, concluir que as alterações trazidas pela Lei nº 13.467/2017, em relação à terceirização trouxeram prejuízos e acentuaram a condição de trabalhadores em condições inadequadas.
LIBERDADE DE EXPRESSÃO E CENSURA JUDICIAL: UMA ANÁLISE DA INTERNET
Authors: Sousa Peterson Pedro Souza , Brito Filho Jose Claudio Monteiro
Published: December 2020

A pesquisa analisou a liberdade de expressão e a censura judicial no contexto inserido pela internet. Por meio do estudo bibliográfico e jurisprudencial, buscou-se definir o conteúdo do direito à liberdade de expressão e o seu exercício através da internet. Em seguida, passou-se a examinar o polêmico Inquérito das “fake news” (4.781 DF), do qual emanaram-se decisões colidentes com as garantias conferidas à liberdade de expressão. Por fim, após a discussão dos resultados, buscou-se evidenciar os perigos da censura judicial nas plataformas virtuais.
INVENTÁRIO EXTRAJUDICIAL: LACUNA LEGISLATIVA SOBRE ATOS QUE DEPENDEM DE AUTORIZAÇÃO JUDICIAL
Authors: Veroneze Flávia Izac , Batista Rogerio Franco , Franceschet Julio Cesar
Published: December 2020

O presente artigo visou discorrer sobre a ausência de previsão legal na legislação brasileira no tocante à prática de atos pelo inventariante no curso do inventário extrajudicial, mais especificamente, aqueles previstos no artigo nº 619 do Código de Processo Civil. Diante disso, o artigo teve como objetivo estudar a intenção do legislador ao editar a lei 11.411/07, que visa a desburocratização e descongestionamento do Poder Judiciário e a possibilidade da prática de atos pelo inventariante independentemente de autorização judicial, desde que devidamente autorizado por todos os demais herdeiros e interessados.
Problems in College English Teaching from the Perspective of College English Teachers and Their Coping Strategies
Authors: Liu Fuhua
Published: December 2020

The present paper is an analysis of problems in college English teaching from the perspective college English teachers and their coping strategies. The four major problems concerning vocabulary-oriented teaching method, collective lesson preparation, on-line and off-line resources and college English teachers’ comprehensive abilities are introduced and analyzed and corresponding coping strategies are offered.
Research on Intangible Cultural Heritage Education and Inheritance in Universities
Authors: Ma Tao
Published: December 2020

This paper first analyzes the advantages and problems of intangible cultural heritage education and inheritance in Chinese universities, and then points out the key points of local universities in constructing the education system of intangible cultural heritage in terms of curriculum setting, textbook preparation and pedagogical reform, and perfecting teacher deployment and teaching conditions.
Irony and Restructuring: Greig’s Postmodern Rewrite of Macbeth
Authors: Chen Lanxi
Published: December 2020

Dunsinane is a postmodern rewrite adapted from William Shakespeare’s play Macbeth by David Greig. This article mainly deals with the problem that specifically, how Dunsinane is rewritten from Macbeth. The article firstly analyzes from rhetorical perspective that irony, the frequently-used literary device in Macbeth is also a prominent rhetorical strategy of rewriting in Dunsinane. The restructuring of the characters Macbeth, Malcolm and Siward from Scottish perspectives as well as the the restructured theme behind the rewrite are also introduced.