bluuebunny/crossref_metadata_2025 huggingface dataset:
Real-life data of patients with hypoparathyroidism: a case-control study
Authors: TAN Vedat , TUZCU Alparslan Kemal , PEKKOLAY Zafer
Published: January 2022

Objective: This study aims to investigate real-life data of patients with hypoparathyroidism.

Material and Method: This retrospective case-control study was carried out in a tertiary endocrine center between 1 January 2010 and 31 December 2019. Patients with a confirmed diagnosis of persistent hypoparathyroidism and healthy controls were included. Demographic characteristics of the patients, laboratory findings, etiologies of hypoparathyroidism, treatments they received, reasons for hospitalization, and complications were investigated.

Results: Sixty-five patients (mean age 42.80±13.4 years, 91% female) with hypoparathyroidism, and 54 healthy controls (mean age 33.58±11.9 years, 65% female) were included. Mean calcium level 7.95±0.92 mg/dl, and mean PTH level 9.99±6.30 pg/ml in hypoparathyroidism. Regarding the etiology of HypoPT, 51 (78%) patients had hypoPT due to surgery; 14 (22%) patients developed HypoPT due to non-surgical causes. In patients with hypoPT who underwent surgery, the mean calcium value was 8.03±0.93 mg/dl; the mean calcium value in patients with non-surgical HypoPT was 7.67±0.85 mg/dl. The mean PTH levels in non-surgical group, other group 10.16±6.21 pg/ml and 9.36±6.82 pg/ml, respectively. The most common surgery was due to multinodular goiter (72%). In 46 percent, the most common treatment was calcitriol 0.5 mcg/day and calcium 2000 mg/day. Nearly half of the patients had treatment non-compliance (46%). Eighteen percent of patients had kidney stones. Forty-three percent of the patients had been hospitalized in the last year. The most common reason for the hospitalization of patients with hypoparathyroidism was hypocalcemia, and the most common reason for this was treatment non-compliance.

Conclusion: In our study, the most common cause of hypoparathyroidism is surgery due to multinodular goiter. The most common reason for hospitalization is treatment non-compliance. Up to one-fifth of patients had kidney stones.
Alteration of cerebral perfusion and cortical thickness in depression episodes: a comparative MRI study
Authors: KILINÇ Özkan , HIZAL Mustafa , ARISOY Özden , ÖZGEDİK Nur , KALAYCIOĞLU Oya
Published: January 2022

Aim: We aimed to determine the difference between cerebral perfusion and cortical thickness between first attack and recurrent in major depression patients. Material and Method: Our study was conducted prospectively between 01.03.2017-03.03.2018 in Izzet Baysal University Psychiatry department. 40 patients (21 first episodes and 19 recurrent episodes) diagnosed with depression according to DSM 5 by the American Psychiatric Association and a control group of 16 healthy individuals were evaluated for cerebral blood flow and cortical thickness with Perfusion MRI. Patients were also evaluated by Hamilton depression rating scale. Findings: The cortical thickness was significantly decreased in recurrent attacks.There was no significant difference of CBF in first episode and recurrent episodes, except cingulate cortex, which showed significantly reduced CBF values in recurrent group. In patients with higher Hamilton depression scale points, the CBF values of insular cortex were decreased. Conclusion: These findings suggests that cortical atrophy and activation of default mode network in recurrent episodes which leads to decreased response to treatment.
The relationship between non-alcoholic fatty liver disease and breast cancer: a retrospective case-control study
Authors: FIRAT Sevde Nur , DURHAN Abdullah , EREL Serap , ÇULHA Cavit
Published: January 2022

Aim: Breast cancer is the most common cancer among women and is one of the main causes of death in women. It is known that some metabolic components that are risk factors for non-alcoholic fatty liver disease are also risk factors for breast cancer. The aim of this retrospective cohort study was to show the prevalence of non-alcoholic fatty liver disease breast cancer patients and the effect of non-alcoholic fatty liver disease on breast cancer development through comparisons with a control group with normal mammography.

Material and Method: The study included 108 patients who were operated on for breast cancer in the general surgery clinic of our hospital between January 2015 and December 2018 and who underwent abdominal ultrasound for breast cancer staging. A control group was formed of 102 women with benign breast lesions on routine mammography and who underwent abdominal ultrasound within 6 months before mammography. The prevalence of diabetes, hypertension and hyperlipidemia and body mass indexes were similar in both groups.

Results: In the evaluation of all the study participants, an association was found between non-alcoholic fatty liver disease and breast cancer. In the obese and non-obese subgroups, non-alcoholic fatty liver disease was significantly associated with breast cancer in the non-obese subgroup. [OR 2.67%, 95% confidence interval [95% CI) 1.1-6.0, p=0.020].

Conclusion: Non-alcoholic fatty liver disease was seen to be significantly associated with breast cancer regardless of known risk factors. This relationship there was in non-obese women with NAFLD, but not in the obese group.
Publication rate of oral presentations presented at national pathology congresses, 5-year analysis
Authors: BUĞRA Aytül , BUĞRA Abdul Kerim
Published: January 2022

Aim: In this study, the contribution of the oral presentations presented at national pathology congresses to the literature was investigated.

Material and Method: A total of 378 abstracts presented at national pathology congresses between 2014-2018 were scanned in PubMed and Google Academic databases. In order to determine whether these abstracts were obtained from thesis studies, they were scanned in the database of the National Thesis Center. The screening was performed simultaneously with the verbal title and authors. The abstracts were examined in terms of the study design, the type of institution where the study was conducted, whether it was a thesis study, the status of its publication in scientific journals, the type of peer-reviewed journal in which it was published, and the time from presentation to publication.

Results: 47.4% (n=179) of 378 papers were retrospective and 52.6% (n=199) were prospective studies. 73.5% (n=278) of the studies of the presentations were done in universities, 23.5% (n=89) in training and research hospitals, and 3% (n=11) in other institutions. 16.9% (n=64) of the abstracts were obtained from the thesis. A total of 27% (n=102) of the abstracts were published in a scientific journal as an article. A significant difference was found in terms of publication in prospective studies compared to retrospective studies (p=0.03). University hospitals had the highest rate (25.5%, n=71). The average period of publication of papers in a scientific journal was 15.0 ±12.3 months (0-68.9) months. 61.8% (n=63) of the abstracts were published in SCI(E) journals, 18.6% (n=19) in other international peer-review journals and 19.6% (n=20) in national peer-review journals.

Conclusion: We believe that researchers should develop not only oral presentation but also encouraging methods to transform studies into publications.
Shifting Fatherhood and Gender: Negotiating Power and Sexuality in Yoruba
Authors: Daniels Oluwasola
Published: January 2022

Indeed, Yorùbá is one of the vastly researched ethnics in Africa, but all the sub-groups, like Àkókó, are not sufficiently known in scholarship. Thus, with specific focus on Àkókó, this paper discusses gender in pre-colonial marital practices. It argues that while some of these practices made fatherhood fluid and accrued uncommon agency to women, others framed women in taboo and sexuality. The central contribution of this paper is that as a study in gender, it brings the discourse within the framework of shifting fatherhood and sexuality in Yorùbá. The study is approached from historical perspective with the methodology of narration and critical analysis of data. This research uses inter-disciplinary approach like ethnography to have full grasp of the marital dynamisms. In all, non-homogenization of history is crucial to understand hierarchies of power that shaped woman history and gender in Yorùbá.
Yorùbá Literary Artists on Youths and Parenthood
Authors: Adagbada Olufadekemi , Adeyemo Olatunde Adeleye , Salami Ejitoyosi O.
Published: January 2022

The youths of any nation are the bedrock of her development, through viable socio-political and economic contributions. They are the indispensable agents of change that can turn the table round for better, especially in developing nations. The natural psycho-biological development of youths and young adults, living in a nation going through socio-political economic and security challenges, coupled with their being nurtured in some cases through faulty parenting, have manifested in the typology of Nigerian youths. The nation now has a high number of misguided youths who portray demeaning image about Nigeria. This study, hinged on Elkind’s (1967) constructionists’ perspective of adolescents’ cognitive development and womanists’ theory as opined by Hudson-Weems (1993) and Kolawole (1997), to the effect that the desire of the agitating African women is complementarity with men in all aspects of life. With these views; exemplified with excerpts from randomly selected Yoruba dramatic, prosaic, and poetic texts, this essay submits that improper parenting, peer group pressure, excessive drive for material wealth, unemployment, poverty, inaccessibility to social and financial aids as experienced by the youths, are some of the reasons why the future appears bleak for Nigeria. The study recommends collective responsibility by parents, to become positive role models for their children by spending undivided and qualitative time with them, thus creating a good and safe environment for their children to be free to express themselves. Corporate organizations and religious bodies should pay back to the society by organizing workshops and low-capital focused entrepreneurial seminars for the youths. Government should as a matter of urgency, put massive employment generation on priority list, ensure a drastic reduction in the years of working experience required before youths’ employment and ensure desirable remuneration for employed youths by individual and corporate bodies.
A Tribute to Chief Raphael Ige Ibigbami (1939-2020): The Father of Modern Nigerian Ceramic Art
Authors: Famule Olawole
Published: January 2022

Awo kìí kú, Awo kìí rùn

 Awo ńpa’pòódà ni

B’Áwo bá p’èhìnd ̣ à tán

K’éni máse s ̣ è’dárò Awo

 The knowledgeable ones do not die and do not become rotten

 They only transition to the spiritual realm of ancestors

Therefore, when a knowledgeable one transitioned

 Let no one mourn but rather celebrate the transition

 Ìyè ̣rè ̣ Ifá dirge for a deceased Babaláwo, Ifá diviner (‘Father of ancient wisdom’).

We celebrate the life of our knowledgeable and well accomplished retired Ceramics Professor at the Obafemi Awolowo University, Ile-Ife, Nigeria, Chief Raphael Ìgè Ibigbami, who transitioned to the realm of ancestors on August 26, 2020.
PENGARUH KEPUASAN KERJA DAN MOTIVASI BERPRESTASI TERHADAP KINERJA MANAJERIAL DIMEDIASI KOMITMEN AFEKTIF PADA KEJAKSAAN TINGGI WILAYAH KALIMANTAN TIMUR
Authors: Ideris Adhitia Ferdinand , Hidayati Tetra , Heksarini Ariesta
Published: January 2022

The purpose of this study is to test the influence between job satisfaction and motivation of achievement on managerial performance with affective commitment as an intervening variable in Kejaksaan Tinggi Kalimantan Timur area. This research is classified as quantitative research that is expected to measure the influence between variables. Data collection was conducted using questionnaires with sampling techniques are saturated samples, as many as 60 respondents. Data processing is done using SEM (Structural Equation Modelling). The results of this study showed that job satisfaction, performance motivation and affective commitment each had a significant positive effect on managerial performance. The results of the analysis also showed that affective commitment mediates the indirect influence between job satisfaction and the motivation of achievement on managerial performance and the nature of partial mediation. The meaning of this research is that the better employee job satisfaction and the higher the motivation of employee achievement, the higher the affective commitment that will further improve employee performance.
KESEIMBANGAN KEHIDUPAN KERJA DALAM MENJALANKAN PERAN GANDA STUDI PADA MAHASISWA UNIVERSITAS PAMULANG
Authors: Wiyanto Wiyanto
Published: January 2022

It is a challenge for each individual who carries out more than one concurrent role in his life (Dual Role) as experienced by Pamulang University Students. Roles need to be aligned and strategies need to be implemented to avoid problems. Problems such as work, family and college conflicts have the potential to occur. This study aims to determine work, family and college conflicts and explore various strategies to overcome conflicts used by Pamulang University students in carrying out multiple roles. Qualitative research methods were used for this research. Data were collected through interviews and questionnaires. Respondents who became the subject of this study were determined through three criteria. The collected data were analyzed and concluded. Research results Work, family and college conflicts experienced by Pamulang University students are caused by pressure in lectures such as, lecture materials, coursework, lecture time, time to do college assignments, tuition fees, missing lecture information, forgetting to do college assignments, problems knowledge. While the pressure at work such as, a lot of work volume, complex work that requires extra brain performance, short time to complete work, infrastructure that is considered lacking, the presence of a leader who does not fit, co-workers who are less comfortable, canteen menus that are considered inadequate. expensive. In addition, the dual roles that are carried out simultaneously also cause their own pressure, for example the pressure to complete work and college assignments at the same time. Various strategies taken by students in carrying out multiple roles in order to minimize conflict and even to resolve conflicts and can lead students to achieve the desired goals. The strategy adopted is adjusted to the type of conflict that exists. Every conflict, pressure requires resolution separately or not the same between one pressure with another pressure.Keywords : Work Life Balance, Multiple Roles
STUDI KOMPARASI PEMBUATAN PAKAN IKAN DENGAN MODEL CANVAS
Authors: Oktavia Sheli
Published: January 2022

One of the main obstacles in fish farming is the problem of feed. Feed sucks up to 70% of the production cost of fish farming. The purpose of this study was to identify the business model in the Mina Perkasa Cangkring Group and the Mujaer Lele Nila Group with the Business Model Canvas approach; create a business model that has been perfected in the Mina Perkasa Cangkring Group and the Mujaer Lele Nila Group, with the Business Model Canvas approach and create improvement programs that can be made from the enhanced business model. The results of the research on identification of customer segments from the Mina Perkasa Cangkring group were vaname shrimp cultivators in the Mina perkasa Cangkring group, vaname shrimp cultivators in Cantigi and Losarang sub-districts. Meanwhile, the Mujaer Lele Nila group was catfish cultivators in the Nila Lele Mujaer Group. Identification of value proposition elements The Mina Perkasa Cangkring group is located in the cultivation area, the quality of the feed offered is relatively good and the price is cheap. Meanwhile, the Mujaer Lele Nila group is only cheap. The identification of customer relationship elements from the Mina Perkasa Cangkring group is a discount for group members and commissions for customers who selling feed. Meanwhile, the Mujaer Lele Nila Group does not take any profit from selling feed to fellow members. Identification of channel elements in the Mina Perkasa Cangkring Group is to use network facilities among shrimp farmers in Cantigi District. Meanwhile, the channel of the mujaer catfish tilapia group uses group members and extension workers. The results of the identification of key activities elements of the Mina Perkasa Cangkring Group are semi-intensive vaname shrimp cultivation and feed production. Meanwhile, the Mujaer Lele Nila group is catfish cultivation and feed manufacture. The results of the identification of key resource elements in the Mina Perkasa Cangkring and Mujaer Lele Nila groups are mini feed factories, warehouses, printing machines, flour machines, mixing machines, raw materials and human resources. Identification of key partnership elements from the Mina Perkasa Cangkring Group and Mujaer Lele Nila, who are providers of raw materials and extension workers. The results of the identification of revenue stream elements in the Mina Perkasa Cangkring and Mujaer Lele Nila groups are the results of the sale of feed. The results of the identification of cost structure elements in the Mina Perkasa Cangkring Group are equipment maintenance, purchase of raw materials, employee salaries, packaging costs and promotion costs. Meanwhile, the cost structure for the Mujaer Lele Nila Group is equipment maintenance, purchase of raw materials and employee salaries.Keywords: Fish Feed Business, Canvas Model
Analisisi Efisiensi Penggunaan Data Berbasis Digitalisasi Dan Keamanan Arsip pada PT Angkasa Pura II Jakarta Periode 2019 – 2020 (24 Bulan) (Studi Kasus Dimasa Pandemi Covid-19)
Authors: Sampurnaningsih Sri Retnaning , Suharyadi Agus , Rusnaeni Nani , Sukasmono Juni , Wulansari Retno
Published: January 2022

Technological advances in the 4.0 era have made digitalization technology develop more rapidly where information can be obtained more quickly and this of course has an impact on the efficiency of data use in the company. This study aims to analyze the efficiency of data use based on data digitization and archive security at PT Angkasa Pura II, during the Covid-19 pandemic. The method used in this study is causal associative with multiple linear regression analysis, classical assumption test and hypothesis testing. The sample in this study uses digitized data, data security and frequency of data usage. The results of this study are data digitization (X1) shows a significant effect on the efficiency of data use (Y). Archive security (X2) shows a significant effect on the efficiency of data use (Y). Furthermore, data digitization and archive security simultaneously have a significant effect on the efficiency of data use. Statistically, the coefficient of determination with an R-square value of 0.489 indicates that the contribution of data digitization and archive security to the efficiency of data use is 48.9% and the remaining 51.1% can be explained from other variables. It can be concluded that with the development of digitalization technology, it is easier for people to use data. The development of digitalization technology, both directly and indirectly, has affected the company's performance which is becoming more efficient in the use of its data so that it has an impact on faster information obtained that can support the decision-making process in a company.Keywords: Digitization, Archive Security, Data Use Efficiency
SOSIALISASI PENCEGAHAN PENULARAN VIRUS COVID-19 PADA KELURAHAN CIPUTAT, CIPUTAT TANGERANG SELATAN
Authors: Sari Shella Puspita , Lestiyadi Ayu Puspa , Dewi Kartika Sari , Indraswari Tutri
Published: January 2022

Kegiatan Pengabdian Kepada Masyarakat ini bertujuan untuk memberikan sosialisasi pencegahan penularan virus Covid-19 terhadap pada staff ataupun peserta. Metode kegiatan yang digunakan adalah kerjasama dengan Bapak Lurah Kelurahan Ciputat, yang beralamat di Ciputat, Tangerang Selatan dan memberikan sosialisasi serta pengarahan cara mengantisipasi penularan virus Covid19 pada masyarakat. Setelah di analisis maka kami memberikan sosialisasi dan pemaparan virus Covid-19 dari mulai gejala yang timbul di lingkungan keluarga dan masyarakat, cara penyembuhan hingga bagaimana menghadapi orang yang sedang mengidap Covid-19. Hasil kegiatan menunjukkan bahwa sebelum pelaksanaan PKM, para staff Kelurahan Ciputat belum mengetahui hal apa saja yang bisa dilakukan untuk meningkatkan pengetahuan tentang penularan virus Covid-19, namun setelah pelaksanaan kegiatan PKM ini diketahui para peserta setidaknya sudah mempunyai sedikit bekal dan dapat memahami virus Covid-19, dan bagaimana cara mengantisipasi penularan virus Covid-19, mengetahui apa saja gejala Covid-19, dan bagaimana cara penyembuhannya. Kegiatan PKM berperan positif dalam meningkatkan pengetahuan dan pengharapan untuk selalu meningkatkan kebersihan dan jaga kesehatan.Kata Kunci : PKM, Sosialisasi, Pencegahan, Penularan, Virus Covid-19
PEMBERDAYAAN ZAKAT DAN WAKAF PRODUKTIF DALAM KAJIAN EKONOMI SYARIAH DAN HUKUM POSITIF DALAM MENINGKATKAN EKONOMI UMAT
Authors: Sadiyah Khotimatus , Hasbiyah AN Wiwik , Haryono Haryono , Samiyono Sugeng , Zamzami R. Mohd
Published: January 2022

Pengabdian masyarakat ini berjudul “Pemberdayaan Zakat dan Wakaf Produktif dalamKajian Ekonomi Syariah Dan Hukum Positif Dalam meningkatkan Ekonomi Umat” yangdilaksanakan di yayasan Al-Kamilah Sawangan Depok. Tujuan pengabdian ini adalahmemberikan penyuluhan dan pendampingan terhadap Santriwan santriwati berkaitan dengan zakat dan wakaf produktif dan hukum positif dengan harapan dengan adanya penyuluhan tersebut pada Santriwan dan santriwati mampu memahami pengetahuan Agama dan pengetahuan hukum negara sehingga santriwan santriwati mampu menerapkan pemberdayaan zakat dan wakaf serta hukum positif bagi diri sendiri khususnya dan bagi masyarakat umumnya di yayasan Alkamilah guna meningkatkan ekonomi umat. Metode pelaksanaan pengabdian ini adalah dengan penyuluhan dan pendampingan melalui rangkaian kegiatan identifikasi, pengkajian serta proses belajar yang terencana dengan 3 tahapan yaitu 1) Pengumpulan data, dengan memberikan data wawancara kepada Santriwan santriwati tentang pemahaman pemberdayaan zakat dan wakaf produktif dalam sudut kajian agama dan hukum 2). Pelatihan pemberdayaan zakat dan wakaf produktif dalam sudut kajian agama dan hukum dengan memberikan penyuluhan kepada Santriwan santriwati di yayasan Alkamilah. 3) Memberikan pendampingan Pelatihan tentang penghitungan zakat dan wakaf produktif dalam sudut kajian agama dan hukum. Untuk mendukung hal itu diperlukan sebuah rencana kegiatan diantaranya adalah tahap persiapan yaitu dengan menyiapkan semua peralatan yang dibutuhkan untuk melaksanan kegiatan pkm, studi literatur dan melakukan koordinasi dengan instansi lembaga yayasan terkait serta ketua yayasan khususnya. Tahap penentuan lokasi, yaitu dengan melakukan kunjungan ke lokasi. Tahap Perancangan implemnetasi dan pengawasan melalui pelatihan pemasaran syariah yang dilakukan oleh 5 orang dosen universitas pamulang fakultas ekonomi prodi akuntansi kepada santriwan santriwati di yayasan Alkamilah sawangan Depok. Kesimpulan dari pengabdian ini adalah peserta pengabdian sangat antusias terhadap pelatihan, hal ini ditunjukan dengan banyaknya antusiasme pertanyaan tentang zakat dan wakaf, baik penghitungan dan pengolahan zakat dan wakaf, serta kajian hukumnya.Kata kunci : Zakat, Wakaf, Agama, Hukum, Sosial, Ekonomi
Pengaruh Layanan Konseling Kelompok dengan Teknik Self-Talk terhadap Burnout Siswa
Authors: Syahriman Syahriman , Herawati Anna Ayu , Nopriani Uni Nopriani
Published: January 2022

This research is motivated by the existence of learning burnout which causes problems for students in learning. This study aims to describe the effect of group counseling services using self-talk techniques on learning burnout of XI MIPA F students at SMA Negeri 2 Bengkulu City. This research method uses an experiment with a one-group pretest-posttest design. There are 35 students of class XI MIPA F as a population with a purposive sampling technique taken as a sample of 6 people. The data collection technique used a Likert scale questionnaire. Data analysis used a T-test (paired sample test). The results obtained in this study indicate a decrease in student learning burnout after being given group counseling with self-talk as a treatment. This is indicated by the value of T = 11,400 and sig (2-tailed) 0,000, which means 0,000 <0.05 so that H0 is rejected and Ha is accepted. This means that there is an effect of group counseling services with self-talk techniques on learning burnout of XI MIPA F students at SMA Negeri 2 Bengkulu City.
Komunikasi Interpersonal melalui Layanan Bimbingan Kelompok di STAI Ma'arif Jambi
Authors: Yulianti Yulianti , Hayati Ria
Published: January 2022

This study aims to determine the application of group guidance services to develop colage student interpersonal communication in STAI MAARIF JAMBI study program BKPI. The research method used is descriptive qualitative. Data obtained from interviews, observations and documentation sourced from students of the BKPI Study Program STAI MAARIF JAMBI. The collected data is followed up with data reduction, data display and drawing conclusions. Group guidance service is one of the services that exist in counseling guidance services, where group guidance services aim to train students to dare to express their opinions, train to convey solutions, practice critical thinking. Group guidance services are expected to be able to improve students' skills in good communication.
Influences of Advertisement on Buying Behaviour
Authors: Utama A.A. Gde Satia , Nair Rajesh Kumar , Cheng Wan En , Kee Daisy Mui Hung , Chen ZeXian , Cheng Min Ru , Cheng ZiHang , Talesara Shruti
Published: January 2022

In this era of advanced technology, sellers are provided with different methods, platforms, and designs to prepare their advertisements. This study examines the ways advertisement influences consumer buying behavior in Malaysia and India. A total of 100 responses were collected from surveys to 51 Malaysian respondents and 49 Indian respondents from universities’ groups, personal friends, and families. The findings indicate that advertising is highly persuasive. Also, we identify that social media ad achieve the most affecting advertising channels. We have also identified the difference of view about the influences of advertisement before and after the pandemic.
A Sorbent with Synthetic Ligand for Removing Pro-atherogenic and Pro-inflammatory Components from Human Blood Plasma
Authors: Dmitrieva Oksana A. , Ovchinnikova Ekaterina D. , Utkina Elena A. , Levashov Pavel A. , Afanasieva Olga I. , Adamova Irina Y. , Pokrovsky Sergey N.
Published: January 2022

Elevated levels of apoB-100 containing lipoproteins and markers of systemic inflammation are often observed in patients with cardiovascular diseases. The concentrations can be reduced by pharmacotherapy or extracorporeal treatment. The sorbent, which removes CRP and atherogenic lipoproteins, simultaneously reduces the bloodstream concentration of these components. The efficacy and selectivity of the designed sorbent were studied, desorption constants of CRP (Kd = 4.2 10-8 M) and LDL (Kd = 7.7 10-7 M) were distribution coefficients of CRP (Kc = 101) and Lp(a) (Kc = 38) were calculated, and the ability to bind large amounts of atherogenic lipoproteins (up to 32 mg of TC per mL of the sorbent gel) was demonstrated. Our sorbent can be recommended for performing complex removal of CRP and atherogenic lipoproteins from the blood plasma in patients with refractory hyperlipidemia and CVD that are accompanied by elevated levels of CRP.
The rs1800470 Polymorphism of the TGFB1 Gene Is Associated with Myocardial Fibrosis in Heart Transplant Recipients
Authors: Gichkun Olga E. , Shevchenko Olga P. , Kurabekova Rivada M. , Mozheiko Natalya Р. , Shevchenko Alex O.
Published: January 2022

The transforming growth factor 1 (TGF1), whose level may depend on the polymorphism of the TGFB1 gene, is involved in the formation of myocardial fibrosis. Myocardial fibrosis in a cardiac allograft may lead to a hearts structural and functional remodeling and subsequent dysfunction. The frequency of occurrence of alleles and genotypes of the TGFB1 gene polymorphic regions rs1800469, rs1800470, and rs1800471 in heart transplant recipients and their association with graft myocardial fibrosis were analyzed. Carriers of the CC genotype (p = 0.023, OR = 0.12, 95% CI: 0.0171.0), and more often the G allele of rs1800471 (p = 0.023, OR = 7.76, 95% CI: 1.060.20), were found among heart transplant recipients less frequently than among healthy individuals. In patients with ischemic heart disease (IHD), the GG genotype was less common (p = 0.035, OR = 2.68, 95% CI: 1.0616.793), while the A allele of rs1800469 was found more frequently (p = 0.035, OR = 0.37 95% CI: 0.1480.942) than in patients with dilated cardiomyopathy (DCM). In heart transplant recipients with the AA genotype of rs1800470, myocardial fibrosis, verified by endomyocardial biopsy, was detected more often than in carriers of the G allele (OR = 10.4, 95% CI: 1.15294.538, p = 0.013). The revealed differences suggest a relationship between TGFB1 gene polymorphism and graft myocardial fibrosis. Studies on a larger group of patients would make it possible to characterize the influence of genetic factors on the formation of myocardial fibrosis in heart transplant recipients.
Nanobodies Are Potential Therapeutic Agents for the Ebola Virus Infection
Authors: Esmagambetov Ilias B. , Shcheblyakov Dmitriy V. , Egorova Daria A. , Voronina Olga L. , Derkaev Artem A. , Voronina Daria V. , Popova Olga , Ryabova Ekaterina I. , Shcherbinin Dmitriy N. , Aksenova Ekaterina I. , Semenov Andrey N. , Kunda Marina S. , Ryzhova Natalia N. , Zubkova Olga V. , Tukhvatulin Amir I. , Logunov Denis Yu. , Naroditsky Boris S. , Borisevich Sergey V. , Gintsburg Alexander L.
Published: January 2022

Ebola fever is an acute, highly contagious viral disease with a mortality rate that can reach 90%. There are currently no licensed therapeutic agents specific to Ebola in the world. Monoclonal antibodies (MAbs) with viral-neutralizing activity and high specificity to the Ebola virus glycoprotein (EBOV GP) are considered as highly effective potential antiviral drugs. Over the past decade, nanobodies (single-domain antibodies, non-canonical camelid antibodies) have found wide use in the diagnosis and treatment of various infectious and non-infectious diseases. In this study, a panel of nanobodies specifically binding to EBOV GP was obtained using recombinant human adenovirus 5, expressing GP (Ad5-GP) for alpaca (Vicugna pacos) immunization, for the first time. Based on specific activity assay results, affinity constants, and the virus-neutralizing activity against the recombinant vesicular stomatitis virus pseudotyped with EBOV GP (rVSV-GP), the most promising clone (aEv6) was selected. The aEv6 clone was then modified with the human IgG1 Fc fragment to improve its pharmacokinetic and immunologic properties. To assess the protective activity of the chimeric molecule aEv6Fc, a lethal model of murine rVSV-GP infection was developed by using immunosuppression. The results obtained in lethal model mice have demonstrated the protective effect of aEv6Fc. Thus, the nanobody and its modified derivative obtained in this study have shown potential protective value against Ebola virus.
Development of Neutralizing Nanobodies to the Hemagglutinin Stem Domain of Influenza A Viruses
Authors: Voronina Daria V. , Shcheblyakov Dmitry V. , Esmagambetov Ilias B. , Derkaev Artem A. , Popova Olga , Shcherbinin Dmitry N.
Published: January 2022

The influenza virus infection claims ~650,000 lives annually. Taking into account the evolving resistance of the pathogen to antiviral drugs and the waning effectiveness of vaccination among certain populations, new approaches to the treatment of influenza are needed. The current study is aimed at obtaining single-domain antibodies (Nanobodies) to the highly conserved stem domain of influenza A virus hemagglutinin by phage display. Two high-affinity neutralizing clones of Nanobodies with a particular specificity were selected; they ensured 100% neutralization of the H1N1 and H5N2 influenza viruses in vivo. The obtained data demonstrate that it is possible to develop highly effective VHH-based drugs for the treatment of influenza.
A Comparative Analysis of CSF and the Blood Levels of Monoamines As Neurohormones in Rats during Ontogenesis
Authors: Murtazina Alya R. , Bondarenko Nadegda S. , Pronina Tatiana S. , Chandran Kristina I. , Bogdanov Vsevolod V. , Dilmukhametova Lilya K. , Ugrumov Michael V.
Published: January 2022

According to the literature, the cerebrospinal fluid (CSF) in the cerebral ventricles contains numerous neuron-derived physiologically active substances that can function as neurohormones and contribute to volume neurotransmission in the periventricular region of the brain. This study was aimed at carrying out a comparative analysis of CSF and the blood levels of monoamines in rats during ontogenesis as an indicator of age-related characteristics of monoamine transport to body fluids and their function as neurohormones in volume neurotransmission in the periventricular region of the brain. We have shown that CSF in the perinatal period and adulthood contains the most functionally significant monoamines: dopamine, noradrenaline, and serotonin. A comparison of the monoamine levels in the CSF and blood of animals of different age groups revealed that CSF contains monoamines of predominantly neuronal (cerebral) origin and almost no monoamines derived from the general circulation. We also established that monoamines are found in the CSF at physiologically active levels that allow them to act as neurohormones in both reversible volume neurotransmission in the adult brain and irreversible regulation of brain development in the perinatal period.
Competências socioemocionais em publicações em educação nos últimos cinco anos: uma breve revisão
Authors: Ferreira Ricardo Batista , Fecury Amanda Alves , Oliveira Euzébio de , Dendasck Carla Viana , Dias Claudio Alberto Gellis de Mattos
Published: January 2022

O conceito de competência é composto pelas nossas ações racionais e emocionais influenciadas por fatores socioculturais. A competência aliada ao controle das emoções em situação social facilita a resolução de conflitos. O objetivo deste trabalho foi fazer uma revisão bibliográfica sobre competências emocionais em educação presentes em publicações nos últimos cinco anos. O método utilizado foi uma breve revisão bibliográfica sobre competências socioemocionais em publicações sobre educação entre 2017 e 2021, em língua portuguesa, em bases de dados de pesquisa Google Acadêmico. É preciso identificar quais competências são necessárias e quais podem ser desenvolvidas no ambiente escolar. As políticas educacionais parecem exigir a inclusão de competências socioemocionais nos currículos da educação básica, porém ocorre a falta de capacitação dos professores. A reestruturação dos currículos deveria também abranger situações diárias de ensino que fossem possíveis de serem realizadas, a partir da reorganização dos espaços pedagógicos, alinhado às estratégias de ensino fundamentadas nas competências. A modernização dos currículos com a inclusão de competências socioemocionais proporciona aos alunos uma formação integral (omnilateral). Na Educação profissional e Tecnológica (EPT) o saber técnico-profissional deve ser para além de uma formação de conteúdo, preparando os discentes para enfrentarem situações reais da futura profissão. A vida adulta, e a vida no trabalho, exige comportamentos e conhecimentos que o aluno utilizará em sua prática social e profissional, fora do ambiente escolar.
Права людини в особливих правових режимах: досвід України
Authors:   кафедра конституційного права Національного університету «Одеська юридична академія»
Published: January 2022

Монографія підготовлена кафедрою конституційного права Національного університету «Одеська юридична академія» із запрошенням експертів, науковців інших установ та організацій. Монографія є колективною науковою працею, результатом критичного переосмислення конституційно-правової дійсності та реалізації прав людини в Україні в умовах особливих правових режимів. Авторами проведено конституційно-правовий аналіз правових засад міжнародного права прав людини, міжнародного гуманітарного права, а також національної законодавчої бази та судової практики, щодо права держав вживати заходів у відступі від своїх юридичних зобов’язань у надзвичайних ситуаціях. Для студентів, аспірантів, викладачів юридичних вишів і факультетів, юристівпрактиків, працівників державних органів і органів місцевого самоврядування, а також фахівців у галузі конституційного права, захисту прав людини. The monograph was prepared by the Department of Constitutional Law of the National University "Odessa Law Academy" with the involvement of experts, scientists from other institutions and organizations. The monograph is a collective scientific work, the result of a critical rethinking of the constitutional and legal reality and the implementation of human rights in Ukraine in conditions of special legal regimes. The authors conducted a constitutional and legal analysis of the legal framework of international human rights law, international humanitarian law, as well as the national legal framework and case law on the right of states to take measures to derogate from their legal obligations in emergencies. It is prepared for students, graduate students, teachers of law schools and faculties, lawyers, practitioners, government officials and local governments, as well as specialists in the field of constitutional law, human rights.
МОНІТОРИНГ ХВОРОБ ШКІРИ СОБАК В УМОВАХ ПРИВАТНОЇ ВЕТЕРИНАРНОЇ КЛІНІКИ «АЛЬФА-ВЕТ», М. КОНОТОП
Authors: Стоцька Ольга Ігорівна
Published: January 2022

В роботі був проведений моніторинг захворюваності собак на дерматити поліетіологічного походження. Дерматит – загальне визначення для будь-якого типу запалення шкіри. Цей термін, зазвичай, використовують для опису стану шкіри до досягнення конкретного діагнозу. Існує безліч причин запалення шкіри, включаючи зовнішні подразники, опіки, алергени, травми та інфекції (бактеріальні, вірусні, паразитарні або грибкові). Дерматит також може бути пов’язаний із захворюваннями внутрішніх органів Дослідження проводилися на базі клініки ветеринарної медицини «Альфа-вет» (м. Конотоп, вул. Красногірська 4а) в період 2020-2021 рр. Пацієнтами для проведення досліджень були хворі на дерматити собаки порід мопс, ягд-тер’єр, лабрадор, стафордширський тер’єр, німецька вівчарка, шарпей, такса, французький бульдог, різних вікових груп та статі. Всього клінічно за цей період було обстежено 730 собак. При постановки діагнозу враховували дані анамнезу, клінічні ознаки, результати мікроскопічних досліджень, клінічні та біохімічні показники крові, цитологічні дослідження. Саркоптичний дерматит був зареєстрований у восьми випадках, в яких, крім саркоптичних кліщів, також були помічені нейтрофіли, макрофаги та плазматичні клітини та ороговілі епітеліальні клітини. Гематологічними дослідженнями встановлена відносну нейтрофілія та легка еозинофілію. Важкого та генералізованого демодекозу, ускладненого бактеріями та Malassezia sp. також було зафіксовано у 28 випадках зараження. Гістопатологічно численні Demodex sp. було виявлено кліщів у різній стадії дозрівання, які пошкоджують волосяні фолікули разом із супутніми патологічними змінами та гранулемами стороннього тіла. Крім того, алергічний дерматит від бліх також спостерігався у 89 собак. Цитологія виявилася однозначно ефективною при діагностиці паразитарного дерматиту. Собак з атопічним дерматитом було зафіксовано 28 випадків. Однак виникнення нових випадків постійно зростає. Патогенетичні механізми цього захворювання до кінця не вивчені, проте доведено участь аномальних генів та змінених імунологічних процесів. У собак діагноз атопічного дерматиту ґрунтується на зборі анамнезу, клінічному обстеженні та диференційній діагностиці. Основну частину захворювань займають алергічні хвороби шкіри та бактеріальні захворювання шкіри собак. При проведенні моніторингу дерматитів у собак було встановлено, що алергічні дерматити складали 63,01 % випадків; паразитарні – 24,66 %, грибкові – 9,32 % та бактеріальні – 3,01% Найбільш складні у діагностуванні та лікуванні атопічний, контактний та алергічний дерматити.
АНАЛІЗ ЗАСТОСУВАННЯ ФІТОПРЕПАРАТІВ ФІРМИ AMMA
Authors: Кистерна Олеся Сергіївна , Мусієнко Олексій Володимирович , Тендітнік Роман Олександрович
Published: January 2022

У статті наведено результати аналізу ринку фітопепаратів. Встановлено, що 89 % ветеринарних фітопрепаратів на ринку України для різних видів тварин представлені вітчизняними виробниками, такими як: "O.L.KAR-АгроЗооВет-Сервіс", "Дивопрайд", "Укрзоветпромпостач", "Природа", "Бровафарма", "Укрветпромпостач", "Ветпрепарати", "Фарматон", більшість з яких мають протипаразитарне і гігієнічне значення та окремі препарти гепатопротекторної дії – «Карсилін», "Бровафарма". Фітопрепарати з лінійкою для лікування і профілактики різних патологій для дрібних тварин представлені: 10 % – російськими виробниками: "Veda" – «Кот Баюн», «Кот Ервін» і «Фітоміни» – фірма «Апісан». Та 1% – це препарати українського виробництва компанії «Амма Лайф Саєнсіз» із індійської сировини, що є виробником фітокомплексів для людей і тварин. Такі як: Стоніл Вет (сечовивідна система), Ревма Вет (опорно-руховий апарат), Лівофер Вет (печінка, травна система), Імуно Вет (імунітет), Карді Вет (серцево-судинна система), Пурісан Вет (протиалергічнна дія), Мансі Вет (нервова система), Крумі Вет (виведення гельмінтів), Глюко Вет (контроль глюкози), Фемі Вет (репродуктологія). Спостереження за станом шпиця після курсу етіотропної терапії лептоспірозу, з хронічними патологіями бронхолегеневої (звуження трахеї) та сечовивідної систем на фоні використання фітопрепаратів «АММА» впродовж п’яти місяців: з ветеринарної лінійки: Стоніл Вет (сечовивідна система), Мансі Вет (нервова система);– Сумишварі – з лінійки для людей, демонструє нормалізацію загального стану пацієнта по виявленим патологіям. А саме: зникли тривалі спазматичні напади кашлю, що інколи проявлялися на фоні психоемоційного навантаження без агресивного і тривалого прояву; зменшилась збудливість нервової системи на різні фактори, що викликали занепокоєння; нормалізувалося сечовиділення та показники сечі, зменшилася кількість і розмір уролітів в сечовому міхурі, що свідчить про ефективність дії фітопрепаратів «АММА»: Стоніл Вет, Мансі Вет, Сумишварі за хронічної бронхолегеневої та сечової патологій. Досягнуте покращення стану даного конкретного пацієнта – шпиця з виявленим патологічним звуженням трахеї на фоні використання комплексу фітопрепаратів фірми «АММА», не може бути класичним прикладом стабілізації стану без проведення хірургічного втручання – стенування трахеї та досягнута компенсація потребує подальшого спостереження. Даний клінічний випадок на фоні комплексного підходу лікування до пацієнта, якому по певним причинам не могла бути проведена операція, свідчить про можливість застосування подібних схем лікування з метою покращення якості життя та мінімізації загрозливих симптомів з боку бронхолегеневої системи.
ВИЗНАЧЕННЯ ВПЛИВУ ЗБУДНИКІВ МАСТИТУ НА СКЛАД МОЛОКА
Authors: Титух Ярослав Вікторович
Published: January 2022

Традиційно ідентифікація і діагностика мікоплазм проводилися за допомогою мікробних культур. Зовсім недавно використання полімеразної ланцюгової реакції запропоновано для виявлення мікоплазм з молока великої рогатої худоби. Полімеразна ланцюгова реакція має більш високу ефективність, специфічність і чутливість для лабораторної діагностики в порівнянні з традиційними методами, заснованими на мікробіологічних дослідженнях. Дослідження проводили ТОВ «Агрофірма Лан», Сумська обл., Сумський р-н, с. Кіндратівка. Процедури поводження з тваринами в рамках дослідження були затверджені Комітетом з етики Сумського національного аграрного університету (затвердження №: 2017/01). Експерименти виконувались на коровах голштинської породи 1-5 лактації. Загалом було досліджено 200 голів. Захворювання на мастит визначали за допомогою каліфорнійського тесту та визначення кількості соматичних клітин у молоці. Проби молока для дослідження збирали під час ранкового доїння з кожної чверті вимені щотижня. Всі дослідження експерименти виконувались згідно рекомендацій та норм. Також у молоці мікробіологічними методами визначали мікроорганізми-збудники субклінічного маститу. Сортність молока за кМАФАнМ визначали згідно з ДСТУ 7357, ДСТУ 7089, ДСТУ ISO 4833, ДСТУ IDF 100B та соматичних клітин згідно з ДСТУ ISO13366-1, ДСТУ ISO13366-2, ДСТУ 7672. Крім того, були проведені молекулярно-генетичні дослідження біологічного матеріалу (молоко) від корів у ПЛР. Дослідженнями було встановлено, що кількість соматичних клітин (КСК) у молоці корів 1 дослідної групи було більше на 1265 %, кількість мезофільних аеробних і факультативно-анаеробних мікроорганізмів (кМАФАнМ) було більше на 31 %, порівняно до здорових тварин у контролі. Також у корів 1 дослідної групи шляхом проведення ПЛР у молоці була виявлена Mycoplasma spp. У другій дослідній групі, де був виділений Staphylococcus spp.у молоці, КСК було вище на 18,5% та кМАФАнМ – на 1010 %. У корів 3 дослідної групи основний патоген у молоці був виділений E. coli . При цьому КСК було вище на 24 %, а кМАФАнМ – на 1108 %, порівняно до здорових тварин. За результатами проведених досліджень було встановлено, що виділені ізоляти мікроорганізмів проявляли чутливість до пеніцилінових, аміноглікозидів та цефалоспоринофих груп антибактеріальних препаратів.
Using discarded oyster shells to obtain biodiesel
Authors: De la Cruz-De la Cruz Miguelina , De la Cruz Burelo Patricia , Hernández-Núñez Emanuel , Santiago-González Ramón Eduardo , Valerio-Cárdenas Cintya , Villegas-Cornelio Víctor Manuel
Published: January 2022

Objective: To evaluate the CaO made from oyster shell (C. virginica) as a heterogeneous catalyst in the transesterification of edible vegetable oil used for the production of biodiesel.
Design / methodology / approach: A completely randomized experimental design was used, which grouped 3 treatments with 3 repetitions, generating a total of 9 experimental units. The response variable was the performance of the transesterification reaction that was evaluated with 2%, 3% and 4% of CaO obtained from oyster shells. The density, kinematic viscosity, acidity, and conversion efficiency to methyl esters were determined by 1H NMR of the products of each treatment.
Results: The treatment with 3% catalyst showed the highest reaction yield (92.2%) compared to the treatments with 2% (86.8%) and 4% catalyst (87.13%). The 1H NMR spectra confirmed the presence of methyl esters in the product of the three treatments. The treatment with 3% and 4% by weight of catalyst presented products with similar characteristics with acceptable values ​​of density, viscosity and acid number in accordance with the ASTM D6751 and EN1421 standards.
Study limitations / implications: A concentration of 2% by weight of CaO generates a conversion percentage far from the content of methyl esters established by the ASTM D6751 and EN14214 Standards (> 96.5%).
Findings / conclusions: 1H NMR results indicate that the conversion efficiency to methyl esters is positively affected by the amount of catalyst. In the treatments with catalyst loading greater than 2%, the conversion to methyl esters increased significantly to values ​​around 90%.