bluuebunny/crossref_metadata_2025 huggingface dataset:
DRAMATIZAÇÃO PARA PROMOÇÃO EM SAÚDE E SUA RELAÇÃO COM OS INSTRUMENTOS BÁSICOS PARA O CUIDAR
Authors: Da Silva Barreto Ferreira Ruan , Maciel da Silva Sheila , Pereira dos Santos Jéssica Larissa , Marciano Cavalcante Érica , Guedes Oliva Fernandes Andréia , Raminelli da Silva Talita de Cássia
Published: December 2019

No âmbito da assistência à saúde, a enfermagem possui autonomia com participação ativa na promoção e prevenção, exigindo do graduando um embasamento teórico-prático que pode ser adquirido por diferentes metodologias de ensino. Objetivando descrever a experiência de discentes e docentes do curso de graduação em enfermagem, em uma atividade de promoção de saúde relacioná-la com os Instrumentos Básicos do Cuidar, através de relato de experiência e por meio da dramatização, foi possível vivenciar a aplicação dos instrumentos básicos de enfermagem preconizados por Wanda Horta, utilizados no exercício profissional do enfermeiro. Acredita-se que o uso da dramatização como metodologia ativa é importante instrumento no processo do cuidar.
Análise do comportamento da morbimortalidade hospitalar em idosos iguaçuenses:
Authors: Gutiérrez Murillo Roberth Steven , Gamarra Carmen Justina
Published: December 2019

Trata-se de um estudo epidemiológico transversal retrospetivo, de cunho analítico-descritivo e com abordagem quantitativa, que investigou o comportamento da morbimortalidade hospitalar do idoso iguaçuense – PR, no período de 2010 a 2018, por meio de uma consulta on-line ao Departamento de Informática do Sistema Único de Saúde do Brasil (DATASUS), sendo interpretadas as principais causas de morbimortalidade segundo CID – 10. Foram incluídos neste estudo registros hospitalares de indivíduos com idade igual ou superior os 60 anos, de ambos os sexos. Dentre a população estudada, destacou-se maior incidência de internação hospitalar em homens (55%), sendo 2012 o ano como mais registros de internação e, 2010 o menor. As três principais patologias que acometem ao idoso iguaçuense são, respetivamente: neoplasias (23,26%); doenças do aparelho circulatório (20,89%) e doenças do aparelho respiratório (11,96%). A maior mortalidade foi concentrada, de modo majoritário, nas seguintes patologias: doenças do aparelho respiratório (25,4%); neoplasias (22,2%) e doenças do aparelho circulatório (18%). A adoção em todo o território paranaense do Linha Guia de Saúde do Idoso em 2017 se considera um ganho para a população envelhecida, na medida em que objetiva promover a autonomia e a independência do idoso, além do reconhecimento dos direitos prescritos em Lei maior.

Palavras-chave: Foz do Iguaçu-PR; Morbimortalidade hospitalar; Saúde do idoso
Recent Advances in the Straps/Strips Technique for Out-of-plane Strengthening of Load-bearing Masonry Walls
Authors: Ferretti Elena
Published: December 2019

As is well known, the main contribution of the FRP strips to the strength of load-bearing walls is an improvement in the in-plane strength. This paper deals with the possibility of applying the FRP strips in way to modify the strengthening mechanism of the FRP reinforcing system, from an in-plane to an out-of-plane strengthening mechanism. In order to achieve this goal, a second reinforcement system – derived from the CAM system (Active Confinement of Masonry) – provides connections between the FRP strips placed on the opposite sides of the wall. This new strengthening technique – called the straps/strips technique – establishes a stiffness constraint that forces the opposing FRP strips to behave like two flanges of an FRP I-beam embedded in the wall. Consequently, the use of FRP strips also improves the flexural strength of the wall. The present paper briefly summarizes the results obtained in previous works with the straps/strips technique and proposes an improvement of this strengthening technique, based on some weak-points emerged in the early experimentations. The paper also shows the results of a further experimental test, performed with the improved straps/strips technique. Finally, the similarity between FRP strips with transversal connection and concrete wythes of a sandwich panel with flexible connectors leads to interpret the behavior of the ideal I-beam in terms of composite action established between the FRP strips. This paves the way for analytical modeling of the straps/strips technique.
Learning from Patient and Site Perspectives to Develop Better Mobile Clinical Trials: Recommendations from the Clinical Trials Transformation Initiative
Authors: Geoghegan Cindy , Nido Virginia , Botto-Ven Bemden Angie , Hallinan Zachary , Jordan Les , Kehoe Lindsay , Morin Steve , Niskar Amanda , Okubagzi Petros , Wood William
Published: December 2019

In order to harness the potential of mobile technologies to enhance the quality of clinical research, it is critical to first understand how to engage patients and research sites when planning and conducting mobile clinical trials. The Clinical Trials Transformation Initiative has developed the first comprehensive, evidence-based set of recommendations for incorporating patient and site perspectives in mobile clinical trials, which can aid in engaging stakeholders, addressing site challenges, and maximizing value for participants.
TINGKAT KESUKAAN KONSUMEN DAN KUALITAS ORGANOLEPTIK PRODUK OLAHAN IKAN
Authors: Amir Nursinah , Metusalach Metusalach , Fahrul Fahrul
Published: December 2019

Produk olahan ikan merupakan bentuk diversifikasi produk yang menggunakan ikan sebagai bahan dasar.  Penelitian ini bertujuan untuk mengetahui tingkat kesukaan konsumen dan kualitas organoleptik produk olahan ikan. Sampel produk olahan ikan meliputi bakso, abon, nugget dan otak-otak. Sampel diambil dari kelompok pengolah hasil perikanan Buyang Sejahtera dan Barokah di Kelurahan Kampung Buyang Kecamatan Mariso Kota Makassar.  Tingkat kesukaan dan kualitas organoleptik ditentukan dengan menggunakan kusioner dan panelis.  Hasil menunjukkan bahwa rata-rata panelis mengatakan sangat suka terhadap produk abon dan nugget kelompok pengolah Buyang sejahtera, sangat suka terhadap produk otak-otak Kelompok Barokah, suka terhadap produk otak-otak kelompok Buyang Sejahtera serta suka terhadap produk nugget dan bakso Kelompok Barokah.
DISTRIBUSI JUVENIL TUNA BERDASARKAN HASIL TANGKAPAN PURSE SEINE DI LAUT BANDA
Authors: Rais Mohammad , Hamka Eddy , Parisa La Ode
Published: December 2019

Tuna merupakan salah salah satu jenis ikan ekonomis penting di Indonesia dan menjadi salah satu komoditas eksport utama sektor perikanan, sehingga diperlukan adanya pengelolaan yang terencana untuk menjamin keseimbangan antara pemanfaatan dan populasi tuna. Pelabuhan Perikanan Samudera (PPS) Kendari sebagai pusat pendaratan ikan menunjukkan masih banyak juvenil tuna oleh (bangkumis) tertangkap khususnya pada alat tangkap purse seine.  Tujuan dari penelitan ini yaitu untuk mengetahui (1) distribusi ukuran panjang menggunakan analisis distribusi frekuensi, (2) Produktivitas penangkapan juvenil tuna yang tertangkap menggunakan analisis CPUE, (3) Sebaran spasial lokasi penangkapan juvenil tuna menggunakan analisis spasial (GIS). Penelitian dilaksanakan pada januari sampai juni 2017 di laut banda dengan Fishing base Pelabuhan Perikanan Samudera. Pengumpulan data dilakukan dengan mengikuti operasi penangkapan purse seine pada 30 Titik penangkapan lalu melakukan pencatatan ukuran panjang dan berat total tagkapan juvenil  tuna.  Hasil penelitian menunjukkan ukuran juvenil  tuna yang tertangkap di laut banda memiliki rentang ukuran 22,5 cm - 55,4 cm. Produktivitas penangkapan dilihat dari nilai CPUE perbulan pada semua alat tangkap purse seine yang menangkap juvenil tuna di laut banda. CPUE tertinggi pada bulan juni dengan nilai 2728 kg per unit penangkapan dan terendah pada bulan maret dan april dengan nilai 1243 kg per unit penangkapan. Lokasi penangkapan juvenil tuna selama penelitian tersebar di wilayah Utara, tenggara dan selatan laut banda (030 LU – 060 LS, 1220 BT – 1240 BT). Penelitian ini memberi berkontribusi dalam perumusan kebijakan pengelolaan perikanan tuna di Indonesia, khususnya di Sulawesi Tenggara, sehingga stok sumberdaya ikan tuna secara jangka panjang akan terjaga yang pada akhirnya berdampak bagi keberlanjutan ekologi dan ekonomi usaha perikanan tuna. Kata kunci : GIS, CPUE, Produktivitas, PPS Kendari, Tuna
Using a qualitative and quantitative validation methodology to evaluate a drone detection system
Authors: Doroftei Daniela , De Cubber Geert
Published: December 2019

Now that the use of drones is becoming more common, the need to regulate the access to airspace for these systems is becoming more pressing. A necessary tool in order to do this is a means of detecting drones. Numerous parties have started the development of such drone detection systems. A big problem with these systems is that the evaluation of the performance of drone detection systems is a difficult operation that requires the careful consideration of all technical and non-technical aspects of the system under test. Indeed, weather conditions and small variations in the appearance of the targets can have a huge difference on the performance of the systems. In order to provide a fair evaluation, it is therefore paramount that a validation procedure that finds a compromise between the requirements of end users (who want tests to be performed in operational conditions) and platform developers (who want statistically relevant tests) is followed. Therefore, we propose in this article a qualitative and quantitative validation methodology for drone detection systems. The proposed validation methodology seeks to find this compromise between operationally relevant benchmarking (by providing qualitative benchmarking under varying environmental conditions) and statistically relevant evaluation (by providing quantitative score sheets under strictly described conditions).
Features of the human immune response to Helicobacter pylori infection
Authors: Novikov V. V. , Lapin V. A. , Melentiev D. A. , Mokhonova E. V.
Published: December 2019

Helicobacter pylori is considered the etiological agent of acute and chronic forms of gastritis, and is also capable of exerting a multifactorial effect on the host organism and on the nature of the immune response. The inflammatory response to H. pylori infection has its own characteristics. With an active course, inflammatory reactions, when the modulating effect of regulatory T-lymphocytes (T-reg) is weakened and populations of pro-inflammatory cells (T-helpers 1, 17, 22 type and follicular T-helpers) are activated, which have pronounced destructive changes in the gastric mucosa and the duodenum. guts. Macrophages, dendritic cells and neutrophils are cellular factors of the innate immune system, as well as adaptive immunity, which provides protection against infection. In turn, H. pylori uses a variety of mechanisms to evade the destruction of the host immune system. Long-term preservation of inflammation can cause local activation of mutagenesis, which initiates the development of malignant neoplasms of the gastric mucosa. A review of the host immune response to H. pylori is devoted to this analytical review.
Correlation of Mobility Reduction of HPAM Solutions at High Velocity in Porous Medium with Ex-Situ Measurements of Elasticity
Authors: Jouenne Stephane , Heurteux Guillaume
Published: December 2019

When injected at high flow rates in a porous medium, polymer solutions exhibit a resistance to flow that is a signature of chain conformation and size. For biopolymers, which exist in solution as semirigid rods, mobility reduction follows the shear-thinning behavior measured in shear flow on a rheometer. For flexible coils, such as hydrolyzed polyacrylamide (HPAM), flow thickening is observed in a porous medium, whereas bulk viscosity presents a shear-thinning behavior. This difference is the result of the complex flow experienced in the porous medium, combined with the viscoelastic properties at large strains of the solutions.

In this study, we investigate the effect of physicochemical parameters such as salinity, polymer concentration, molecular weight, and degradation state on the mobility reduction in a porous medium at high flow rates. All the experiments are performed on a short-length, 4-darcy sintered ceramic core. The bell shape of the mobility-reduction curves (mobility reduction vs. flow rate) is characterized by three parameters: the onset rate of flow thickening (QC), the maximum of mobility reduction (Rmmax), and the flow rate at which this maximum occurs (Qmax). Curves are rescaled by use of the two groups, Rm/Rmmax and β×Q, where β accounts for the shift in Qmax when physicochemical conditions are varied. After rescaling, all the normalized mobility-reduction curves are superposed. We show that the two parameters Rmmax and β are not correlated with the bulk viscosity of the solutions but rather with their elasticity evaluated through screen-factor measurement. This old and rough measurement, widely used in the enhanced-oil-recovery (EOR) community to evaluate “solution elasticity,” is an indirect measurement of the extensional viscosity of polymer solutions. The pertinence and the physical meaning of this rough measurement are assessed through comparison with measurements performed on a newly developed extensional viscometer [EVROC™ (Extensional Viscometer/Rheometer On a Chip), RheoSense, Inc., San Ramon, California, USA], which consists of measuring the pressure drop when the fluid is injected through a hyperbolic contraction (in which the strain rate is constant at the centerline). A correlation of “screen factor” vs. “extensional viscosity” is obtained.

These results give some insight on the behavior of polymer solutions in injectivity conditions along with a method to characterize their elastic properties from bulk measurements. Finally, the inadequacy of traditional small-strain viscoelastic measurements to characterize the elastic behavior of polymer solutions at large strain is discussed.
Moderate and deep sedation for non-invasive paediatric procedures in tertiary maternity and children’s hospitals in China: A questionnaire survey from China
Authors: Li Bo , Zhang Ruidong , Huang Yue , Zhang Kan , Wat Chun Yin , Bai Jie , Zhang Mazhong , Zheng Jijian
Published: December 2019

Background: Moderate and deep sedation are well-established techniques in many developed countries, and several guidelines have been published. However, they have received attention in China only in recent years. The aim of this study is to investigate current paediatric sedation practices in tertiary children’s hospitals and tertiary maternity and children hospitals in China. Methods: All tertiary children’s hospitals and tertiary maternity and children hospitals registered with the National Health Commission of the People’s Republic of China were invited to participate in an electronic survey, which included information on the sedation caseload, facility availability, staff structure, clinical skill requirements for sedation providers, fasting guidelines, patient-monitoring practices, and choice of sedatives. Results: Fifty-eight of the 63 hospitals that completed the survey (92.1%) provided moderate and deep sedation. Dedicated sedation rooms and post-sedation recovery rooms were found in 14 (24.1%) and 19 (32.8%) hospitals, respectively. Sedation for non-invasive procedures was primarily performed by anaesthesiologists (69.0%); however, 75.9% of the sedation providers had not received paediatric basic or advanced life-support training. Children were asked to fast from clear liquids for at least 2 hours in 44.8% of hospitals and up to 6 hours in 5.2% of hospitals; they were asked to fast from solid food/milk for at least 4 hours in 27.6% of hospitals and more than 8 hours in 1.7% of hospitals. The most commonly used sedative in all groups was chloral hydrate. For rescue, propofol was the most widely used sedative, particularly for children older than 4 years. Conclusions: Moderate and deep sedation practices vary widely in tertiary children’s hospitals and tertiary maternity and children hospitals in China. Optimised practices should be established to improve the quality of moderate and deep sedation.
The geography of evolutionary divergence in the highly endemic avifauna from the Sierra Madre del Sur, Mexico
Authors: Rocha-Méndez Alberto , SÁNCHEZ-GONZÁLEZ LUIS A. , GONZÁLEZ CLEMENTINA , NAVARRO-SIGÜENZA ADOLFO G.
Published: December 2019

Background: Mesoamerica is a remarkable region with a high geological and ecological complexity. Within northern Mesoamerica, the biotic province of the Sierra Madre del Sur (SMS) in southwestern Mexico harbors exceptionally high avian endemism and diversity. Herein, we searched for spatially and temporally concordant phylogeographic patterns, in four bird genera from three distinct avian orders co-distributed across Mesoamerica and investigated their causes through hypothesis testing regarding historical processes. Selected species include endemic and differentiated populations across the montane forests of Mesoamerica, and particularly within the SMS. Results: We gathered mitochondrial DNA sequences for at least one locus from 177 individuals across all species. We assessed genetic structure, demographic history, and defined a framework for the coalescent simulations used in biogeographic hypothesis testing temporal and spatial co-variance. Our analyses suggested shared phylogeographic breaks in areas corresponding to the SMS populations, and between the main montane systems in Mesoamerica, with the Central Valley of Oaxaca and the Nicaragua Depression being the most frequently shared breaks among analyzed taxa. Nevertheless, dating analyses and divergence patterns observed were consistent with the hypothesis of broad vicariance across Mesoamerica derived from mechanisms operating at distinct times across taxa in the SMS. Conclusions: Our study provides a framework for understanding the evolutionary origins and historical factors enhancing speciation in well-defined regions within Mesoamerica, indicating that the evolutionary history of extant biota inhabiting montane forests is complex and often idiosyncratic.
Health effects of nutrients and environmental pollutants in Baltic herring and salmon: a quantitative benefit-risk assessment
Authors: Tuomisto Jouni T , Asikainen Arja , Meriläinen Päivi , Haapasaari Päivi
Published: December 2019

Background
Health risks linked with dioxin in fish remain a complex policy issue. Fatty Baltic fish contain persistent pollutants, but they are otherwise healthy food. We studied the health benefits and risks associated with Baltic herring and salmon in four countries to identify critical uncertainties and to facilitate an evidence-based discussion.
Methods
We performed an online survey investigating consumers' fish consumption and its motivation in Denmark, Estonia, Finland, and Sweden. Dioxin and methylmercury concentrations were estimated based on Finnish studies. Exposure-response functions for several health endpoints were evaluated and quantified based on the scientific literature. We also quantified the infertility risk of men based on a recent European risk assessment estimating childhood dioxin exposure and its effect on sperm concentration later in life.
Results
Baltic herring and salmon contain omega-3 fatty acids and vitamin D, and the beneficial impact of these fishes on cardiovascular diseases, mortality, and the risk of depression and cancer clearly outweighs risks of dioxins and methylmercury in people older than 45 years of age and in young men. Young women may expose their children to pollutants during pregnancy and breast feeding. This study suggests that even in this critical subgroup, the risks are small and the health benefits are greater than or at least similar to the health risks. Value of information analysis demonstrated that the remaining scientific uncertainties are not large. In contrast, there are several critical uncertainties that are inherently value judgements, such as whether exceeding the tolerable weekly intake is an adverse outcome as such; and whether or not subgroup-specific restrictions are problematic.
Conclusions
The potential health risks attributable to dioxins in Baltic fish have more than halved in the past ten years. The new risk assessment issued by the European Food Safety Authority clearly increases the fraction of the population exceeding the tolerable dioxin intake, but nonetheless, quantitative estimates of net health impacts change only marginally. Increased use of small herring (which have less pollutants) is a no-regret option. A more relevant value-based policy discussion rather than research is needed to clarify official recommendations related to dioxins in fish.
Overexpression of nicotinamide mononucleotide adenyltransferase (nmnat) increases growth rate, Ca2+ content and cellulase production in Ganoderma lucidum
Authors: Wang shengli , Han jing , Xia Jiale , Hu Yanru , Shi Liang , Ren Ang , Zhu Jing , zhao mingwen
Published: December 2019

Background: There is an urgent need to search for new and economical ways to utilize diverse lignocellulose. Ganoderma lucidum is well-known edible medicinal fungus that has a strong ability to degrade a wide variety of cellulosic biomass and its nutrient utilization is closely related to extracellular cellulase. Nicotinamide adenine dinucleotide (NAD+), a nutritional sensor molecule, can respond to nutritional states and regulate cellular metabolism. Nicotinamide mononucleotide adenyltransferase (nmnat) is the key enzyme that catalyses the biosynthesis of NAD+.Result: In this study, a homologue of the gene encoding nmnat was cloned from G. lucidum. The Agrobacterium tumefaciens -mediated transformation (ATMT) method was used to construct the two overexpression strains OE:: nmnat4 and OE:: nmnat19 in G. lucidum. In the overexpression strains, the transcript levels of the nmnat gene and the NAD+ content were significantly increased. Gl nmnat overexpression strains showed dramatically stronger colony growth on different carbon sources, and the intracellular Ca 2+ concentration increased 3.95-fold and 2.10-fold in OE:: nmnat4 and OE:: nmnat19 , respectively, compared with WT strains. The CMCase activity increased by approximately 2.8-fold and 3-fold, and p NPGase activity increased by approximately 1.9-fold and 2.1-fold in OE:: nmnat4 and OE:: nmnat19 strains compared with the WT strains, respectively. Furthermore, it was found that NAD+ might induce cellulase production by regulating cytosolic Ca 2+ concentration.Conclusions: Taken together, our results revealed for the first time that NAD + could stimulate cellulase production and demonstrated that NAD + could increase the transcript levels of cellulase genes via the intracellular Ca 2+ concentration in G. lucidum. This research also provides a theoretical basis for conducting cellulase-related work on other basidiomycetes.
Examining Notions of Uncertainty in the Healthcare Setting: A Qualitative Study
Authors: Meawad Veronica , Fraenkel Liana
Published: December 2019

Background: Shared decision-making relies on the premise that individuals are well-informed regarding the benefits and harms of all available treatment options before coming to a decision regarding their healthcare. There is often significant aleatory and epistemic uncertainty associated with proposed risks and benefits, but prior studies have demonstrated that uncertainty is rarely communicated in provider-patient interactions. Additionally, there has been conflicting evidence regarding the use of visual aids as a method to improve understanding of uncertainty.Methods: We conducted a qualitative, think-aloud study to examine how individuals understand uncertainty as it relates to the probability of medication risks and benefits. We used a within-subjects design and presented individuals with two hypothetical medications after which they received either no additional information, an icon array, or a spinner. We performed individual in-depth interviews following a semi-structured interview guide. Transcripts were analyzed using the constant comparative method of grounded theory.Results: We reached thematic saturation after 20 patient interviews. The participants’ mean (SD) age was 64.6 (18); 60% male, 84% were non-Hispanic Whites, 10% Blacks, and 60% had a college education or higher. Several themes regarding difficulties understanding uncertainty emerged: 1) Rejection of uncertainty; 2) Failure to distinguish between epistemic and aleatory uncertainty; 3) Difficulty distinguishing between different magnitudes of probabilities; 5) Reduction of uncertainty by manipulation of the scenario to eliminate choices. The use of visual aids did not appear to facilitate understanding of uncertainty in most cases.Conclusions: Providers must understand whether and how patients interpret probabilistic information in order to best communicate with them in the healthcare setting. Features such as “talk-back” should be used to ensure reasonable understanding of uncertainty during shared decision-making encounters.
Integrating Protein-Protein Interaction Information into Drug Response Prediction by Graph Neural Encoding
Authors: Xie Yuan , Peng Jian , Zhou Yuan
Published: December 2019

Predicting tumor cells' reactions to medical treatments has enormous significance for both medical and clinical studies. Many machine learning approaches have been previously applied to predict the effectiveness of anti-cancer drugs by analyzing genomic profiles. However, most of the current methods neglect the fact that proteins rarely act alone and often team up as "molecular machines" characterized by intricate dynamic connections to perform biological functions. Other studies indicate that subnetworks of protein-protein interaction (PPI) networks could be crucial for the development of cancer and could be used as new therapeutic targets. Recent advances in graphical representation learning inspired by deep neural networks have provided a potential solution to include PPI information into drug response prediction to improve performance.

We present a graph neural network (GNN) based approach, GNNDR, to incorporate PPI information into drug sensitivity prediction based on genomic profiles. By communicating information among neighborhoods on the PPI network, our model fuses genomic features into a structural PPI graph which encodes information relevant to drug responses. We compare our approach with state-of-the-art baselines on three publicly available datasets which include both genomic features and drug responses of cell lines and Patient Derived Xenografts (PDX). We investigate the impact of different types of interactions as well as the effectiveness of different graph pooling strategies. Experimental results demonstrate the superior performance of our model over the baselines. In particular, on the NIBR-PDXE dataset, our model outperforms the baselines in 21 out of 26 cancer-treatment pairs and achieves a MSE of 1.46 on the CCLE-GDSC dataset and a MSE of 0.11 on the NCI-ALMANAC dataset. In addition, our model provides substantial model interpretability in terms of gene similarity and gene importance via the graph pooling procedures.

We propose GNNDR, a GNN based approach which not only possesses the large learning capacity, but provides a solution to combine PPI information with genomic features for drug response prediction. Empirical evaluation demonstrates the effectiveness of adding protein information. Our approach, as far as we know, the first GNN based model for drug response prediction, provides a promising perspective for the identification of anti-cancer therapies.
Dynamic Modulus and Field Performance of Cold-in-Place Recycled Asphalt Pavement
Authors: Islam M. R. , Kalevela S. A. , Rivera J. A. , Rashid T. B.
Published: December 2019

This study investigates the dynamic modulus of cold-in-place recycling (CIR) asphalt material and its performance using pavement performance data and laboratory dynamic modulus testing. Colorado Department of Transportation (CDOT) has 37 projects with over 8 million square yards using CIR materials. Sites from ten projects were selected to monitor the performances and collect samples for laboratory testing. Dynamic modulus testing on the CIR cores was conducted by the CDOT. Results show measured distresses of CIR rehabilitation techniques are mostly below the threshold values during the service period. International Roughness Index, rutting, and transverse cracking never exceeded the threshold values during the studied period. Only two CIR pavements exceeded the threshold values for fatigue cracking after 8-10 years of service. Measured distresses of CIR rehabilitation techniques are similar to conventional pavements based on engineering judgment. The laboratory dynamic modulus test results show CIR has about 50 % less dynamic modulus compared to the traditional asphalt mixture.

Keywords: asphalt pavement, cold-in-place recycling, dynamic modulus, fatigue cracking, transverse cracking.
Conspecific pheromone extracts enhance entomopathogenic infectivity
Authors: Shapiro-Ilan David I. , Kaplan Fatma , Oliveira-Hofman Camila , Schliekelman Paul , Alborn Hans T. , Lewis Edwin E.
Published: December 2019

Entomopathogenic nematodes (EPNs) provide economic control of various insect pests. However, field efficacy can be inconsistent. The ability of a nematode to find and infect (invade) a host insect is critical to successful pathogenesis. Thus, behaviors including dispersal and infectivity play important roles in improving efficacy. Previously, we discovered that EPN-infected host substances enhance nematode dispersal. Later we found that a mixture of pheromones in the infected host induced dispersal and improved EPN efficacy. In this study, we determined if dispersal-inducing pheromone extracts also increase nematode infectivity (the propensity to invade a host insect). Two nematode species, Steinernema carpocapsae and Steinernema feltiae, and two insect hosts, Galleria mellonella and Diaprepes abbreviatus, were tested. We discovered that conspecific dispersal pheromone extracts of each EPN species enhanced infectivity. These results indicate that the utility of dispersal pheromone extracts for enhancing EPN activity and biocontrol efficacy is improved not only due to increased nematode movement, but also due to increased host infection.
HYBRID MULTIPLE IMPUTATION IN A LARGE SCALE COMPLEX SURVEY
Authors: Razzak Humera , Heumann Christian
Published: December 2019

Large-scale complex surveys typically contain a large number of variables measured on an even larger number of respondents. Missing data is a common problem in such surveys. Since usually most of the variables in a survey are categorical, multiple imputation requires robust methods for modelling high-dimensional categorical data distributions. This paper introduces the 3-stage Hybrid Multiple Imputation (HMI) approach, computationally efficient and easy to implement, to impute complex survey data sets that contain both continuous and categorical variables. The proposed HMI approach involves the application of sequential regression MI techniques to impute the continuous variables by using information from the categorical variables, already imputed by a non-parametric Bayesian MI approach. The proposed approach seems to be a good alternative to the existing approaches, frequently yielding lower root mean square errors, empirical standard errors and standard errors than the others. The HMI method has proven to be markedly superior to the existing MI methods in terms of computational efficiency. The authors illustrate repeated sampling properties of the hybrid approach using simulated data. The results are also illustrated by child data from the multiple indicator survey (MICS) in Punjab 2014.
THE IMPACT OF THE APPLIED TYPOLOGY ON THE STATISTICAL PICTURE OF POPULATION AGEING IN URBAN AREAS IN POLAND – A COMPARATIVE ANALYSIS
Authors: Klimanek Tomasz , Filas-Przybył Sylwia
Published: December 2019

The aim of the paper is to review and compare the processes of population ageing in Polish urban areas. The study presents a novel approach to the problem, because in addition to measuring this phenomenon according to the National Official Register of the Territorial Division of the Country (TERYT) classification, it also measures population ageing according to the classification for urban areas (LAU 2 units) – Degree of Urbanisation (DEGURBA). Several traditional demographic measures for population ageing were applied, such as the median age, parent support ratio, ageing index, elderly dependency ratio, share of people aged 65 and older, and total dependency ratio. Also, Chu’s alternative measure of population ageing accompanied by a dynamic version of ageing index was computed. The values of these indicators for 2016 were compared with those for 2010. The authors carried out a more detailed analysis of the differences between the ageing of populations in urban areas according to the degree of urbanization (DEGURBA), and compared the outcome with the results of the TERYT-based measurement (the traditional administrative territorial division). The comparison of the outcomes of both the above-mentioned ways of measuring the phenomenon of population ageing showed discrepancies, namely the ageing process measured according to the DEGURBA typology proved to be less intensive than the same process assessed according to the TERYT typology. This indicates that there are differences between the statistical pictures of population ageing in urban areas depending on whether demographical and morfological aspects are taken into consideration or not.
ON PERMUTATION LOCATION–SCALE TESTS
Authors: Polko-Zając Dominika
Published: December 2019

Statisticians are constantly looking for methods of statistical inference that would be both effective and would require meeting as few assumptions as possible. Permutation tests seem to fit here, as using them makes it possible to perform statistical inference in situations where classical parametric tests do not work. Permutation tests appear to be comparably powerful to parametric tests, but require meeting fewer assumptions, e.g. regarding the size of the sample or the from of distribution of the tested variable in a population. The presented tests make it possible to verify the overall hypothesis about the identity of both location and scale parameters in the studied populations. In literature, the Lepage test and the Cucconi test are most often referred to in this context. The paper considers various forms of test statistics, and presents a simulation study carried out to determine the size and power of the tests under normality. As the study demonstrated, the advantage of the proposed method is that it can be applied to small-size samples. A nonparametric, complex procedure was used to assess the overall ASL (achieved significance level) value by applying the permutation principle. For comparative purposes, the results for the permutation Lepage test and the permutation Cucconi test are also presented.
SUBJECTIVE AND COMMUNITY WELL-BEING INTERACTION IN A MULTILEVEL SPATIAL MODELLING FRAMEWORK1
Authors: Okrasa Włodzimierz , Rozkrut Dominik
Published: December 2019

Analysing the cross-level interaction between individual and community well-being requires a joint involvement of both ‘vertical’ and ‘horizontal’ perspectives. While multilevel modelling separates the effects resulting from personal characteristics from those resulting from community features, the need to account for spatial variation and geographic membership proves that space and place matter, too. In this paper, the explicitly-spatial multilevel model has been developed to this effect, namely to identify both types of effects, space and place-related, using the hierarchical (nested) data structure for the smallest administrative units – NUTS5/LAU2, i.e. communes (gminas). In their analysis, the authors employed two methods for measuring well-being: (i) individual (subjective) well-being measure derived from the nation-wide Time Use Survey data, which they occasionally replaced with ‘life satisfaction’ type of self-reported measures, and (ii) multidimensional index of local deprivation composed of eleven domain-scales. The spatial multilevel modelling has been extended by an attempt to assess what effect spatial interaction has on cross-level relationships. Its inclusion in the discussion with which this paper concludes seems recommendable, as it indicates the need for more systematic efforts towards a spatially-integrated approach to this kind of modelling problems.
Duality CEO-Chairman and its relation with the effectiveness of the board control
Authors: Freire Cesar
Published: December 2019

The study focused on analyzing the duality CEO-Chairman and its relation on the effectiveness of the board control. A sample of 347 companies with annual sales volume greater than five million US dollars was selected; a questionnaire was provided in order to measure the effectiveness of the board control. To measure the duality CEO-Chairman secondary information was used, and verification was made about the existence of the duality. The effectiveness of the board was measured by an index obtained through the use of confirmatory factorial analysis. Statistical tests were performed, such as Student’s t-test for mean difference, Chi-square to measure the dependence and regression by simultaneous equations to answer the questions. As a result, it was found out that the duality CEO-Chairman is connected in a significant way with the performance of independent directors and risk supervision of the board. The results regarding the duality relationship CEO-Chairman and performance of independent directors are shown to be inverse, while with risk supervision it becomes direct. The obtained results theoretically contribute to the knowledge regarding the practices of good corporate governance.
Transformasi Gender: Strategi Pembebasan Perempuan dari Jerat Pembangunan dan Kapitalisme
Authors: Shalihin Nurus , Firdaus Firdaus
Published: December 2019

Indonesia has long been aware of the importance of gender equality through accommodating women's public rights and recognizing the importance of women's position in development. However, the efforts have not been fully able to create equal and fairness relations between men and women. This conceptual paper is the purpose to explore the main issues in order to develop gender equality relations in Indonesia. Through the study of existing literature, the authors find two main issues on gender equality develop­ment in Indonesia. First, the problem of human resources development policy that not yet based on empowerment oriented. Second, the penetration capitalism on placed the women in not favorable position. In order to solve the two main problems, authors offer a gender transformation as strategies to raise gender equality.
Rozwiązania w zakresie zarządzania ruchomością narządową i unieruchomień stosowanych w radioterapii podczas konferencji ESTRO 36 w Wiedniu.
Authors: Kaczmarek Krzysztof
Published: December 2019

Celem niniejszej pracy było zwrócenie uwagi na najnowsze doniesienia technologiczne i trendy w teleradioterapii. Analizę oparto o wybrane raporty oraz problemy badawcze zaprezentowane podczas dorocznego spotkania ESTRO 36 w Wiedniu.
Rapid Climate Adaption Assessment (RCAA) of water supply and sanitation services in two coastal urban poor communities in Accra, Ghana
Authors: Clemenz Nikolaus , Boakye Richard , Parker Alison
Published: December 2019

This study assessed the impact of different hydrological scenarios on existing vulnerabilities of water and sanitation services in Chorkor and Shiabu, two coastal urban poor communities in Accra, Ghana. The hydrological scenarios were developed from the literature on climate change projections. This paper recommends adaptations for community members, service providers, and the municipality based on the impact assessment. Chorkor and Shiabu are vulnerable to an increase in rainfall because of the lack of adequate solid waste management and hydrological sound drains. Shiabu's topography and the indiscriminate sand mining along its beach make it vulnerable to an increase in sea level. Looking beyond Chorkor and Shiabu's community boundaries, the urban water utility which supplies water vendors in both communities may be severely impacted by a decrease in rainfall, which would lead to water scarcity and a shortage in hydroelectricity. Regardless of which climate change scenario emerges, many of the recommended adaptations are good water management practice, for example, increasing the number of household connections and reducing non-revenue water. Putting climate change high on the agenda has the potential to generate additional funding to help address Chorkor and Shiabu's water and sanitation problems, and climate-proof services for the future. However, the study method does not address the governance of these adaptations.
Predictive Role of BNP/NT-proBNP in Non-Heart Failure Patients Undergoing Catheter Ablation for Atrial Fibrillation: An Updated Systematic Review
Authors: Papageorgiou Nikolaos , Providência Rui , Falconer Debbie , Wongwarawipat Tanakal , Tousoulis Dimitris , Lim Wei Yao , Chow Anthony W. , Schilling Richard J. , Lambiase Pier D.
Published: December 2019

:

Atrial Fibrillation (AF) is a growing public health issue, associated with significant morbidity
and mortality. In addition to pharmacological therapy, catheter ablation is an effective strategy in
restoring and maintaining sinus rhythm. However, ablation is not without risk, and AF recurs in a significant
proportion of patients. Non-invasive, easily accessible markers or indices that could stratify
patients depending on the likelihood of a successful outcome following ablation would allow us to
select the most appropriate patients for the procedure, reducing the AF recurrence rate and exposure to
potentially life-threatening risks.

:

There has been much attention paid to Brain Natriuretic Peptide (BNP) and N-Terminal prohormone of
Brain Natriuretic Peptide (NT-proBNP) as possible predictive markers of successful ablation. Several
studies have demonstrated an association between higher pre-ablation levels of these peptides, and a
greater likelihood of AF recurrence. Therefore, there may be a role for measuring brain natriuretic peptides
levels when selecting patients for catheter ablation.
Characteristics of Blood Lipid Profiles of Professional Athletes: A Literature Review
Authors: Varaeva Yurgita R. , Livantsova Elena N. , Polenova Natalia V. , Kosyura Svetlana D. , Nikitjuk Dmitriy B. , Starodubova Antonina V.
Published: December 2019

Regular physical activity significantly affects lipid status. In this literature review, the specific features
of athletes blood lipid profiles were analysed. Professional athletes blood lipid status was found considerably
preferable compared to sex- and age-matched sedentary population. Regardless of endurance or power type of
sports activities, athletes perform lower levels of TC, LDL-C and TG and comparable or higher blood levels of
HDL-C. The differences in blood lipids levels and sports disciplines were introduced. Although there are much
more factors as diet, place of origin, training regime, and even genetic predisposition that should be taken into
consideration for future research.
An Overview of Recent Advances in Biological and Pharmaceutical Developments of Fluoro-containing Drugs
Authors: Khaligh Nader G. , Abbo Hanna , Titinchi Salam J.J. , Johan Mohd R.
Published: December 2019

:

This review article provides a brief assessment of the biological and pharmaceutical
developments of fluorinated drugs. It also discusses possible impacts on the further
development of new fluoro-containing pharmaceuticals. Structural aspects of new
drug-candidates currently under development and their biological properties, therapeutic
potential and syntheses are critically evaluated
Three Major Phosphoacceptor Sites in HIV-1 Capsid Protein Enhances its Structural Stability and Resistance Against the Inhibitor: Explication Through Molecular Dynamics Simulation, Molecular Docking and DFT Analysis
Authors: Rasool Nouman , Hussain Waqar
Published: December 2019

Background:

Human Immunodeficiency Virus 1 (HIV-1) is a lentivirus, which causes various HIV-associated infections. The HIV-1 core dissociation is essential for viral cDNA synthesis and phosphorylation of HIV-1 capsid protein (HIV-1 CA) plays an important role in it.

Objective:

The aim of this study was to explicate the role of three phosphoserine sites i.e. Ser109, Ser149 and Ser178 in the structural stability of HIV-1 CA, and it’s binding with GS-CA1, a novel potent inhibitor.

Method:

Eight complexes were analyzed and Molecular Dynamics (MD) simulations were performed to observe the stability of HIV-1 CA in the presence and absence of phosphorylation of serine residues at four different temperatures i.e. 300K, 325K, 340K and 350K, along with molecular docking and DFT analysis.

Results:

The structures showed maximum stability in the presence of phosphorylated serine residue. However, GS-CA1 docked most strongly with the native structure of HIV-1 CA i.e. binding affinity was -8.5 kcal/mol (Ki = 0.579 µM).

Conclusion:

These results suggest that the phosphorylation of these three serine residues weakens the binding of GS-CA1 with CA and casts derogatory effect on inhibition potential of this inhibitor, but it supports the stability of HIV-1 CA structure that can enhance regulation and replication of HIV-1 in host cells.
Cytotoxicity, Docking Study of New Fluorinated Fused Pyrimidine Scaffold: Thermal and Microwave Irradiation Synthesis
Authors: Alnaja Alaa M.A. , Farghaly Thoraya A. , El-zahabi Heba S.A. , Shaaban Mohamed R.
Published: December 2019

Background:

Azolopyrimidines are imposed on the arena of drugs treated for cancer.
The urgent need to discover new selective anticancer agents, paved the way to explore the antitumor
significance of such fused systems. From the synthetic point of view, Microwave facilitated
technique for synthesis is very strongly associated with green method in chemistry field.

Aim:

Our aim is to synthesize bioactive compounds using docking simulation run by MOE program
to explore the binding mode of the most active enzyme inhibitor among the target compounds.

Method:

In addition to the use of conventional heating, the MARS system of CEM utilized for
Microwave irradiation that is equipped with a multi-mode platform with a magnetic stirring plate
and a rotor that allows the parallel processing of many vessels per batch. All the synthesized compounds
were tested for their anticancer activity against hepatic cancer (HepG-2), breast cancer
(MCF-7) and colon cancer (HCT-116). Screening against the cancer cell lines was performed, using
doxorubicin as a reference drug. Docking studies were conducted using MOE software.

Result:

A novel series of fluorinated fused-pyrimidine namely, pyrazolopyrimidine, triazolopyrimidine
and pyrimidobenzimidazole were designed and synthesized conventionally and
under microwave irradiations. The mechanistic pathways as well as the structure of all products
were debated and demonstrated based on all possible spectral data. In-vitro examination of the
novel prepared derivatives versus the three different human cancer cell lines [hepatic cancer
(HepG-2), breast cancer (MCF-7) and colon cancer (HCT-116)] was evaluated to estimate their actual
activity.

Conclusion:

We have developed a simple, facile, and efficient procedure for the formation of new
series of azolopyrimidines. All spectra of all products were investigated deliberately to confirm
their structures. The anti-cancer activity has been examined against three cancer cell lines e.g.
HepG-2, MCF-7 and HCT116. Molecular modeling study was carried out in order to rationalize
the in vitro anti-tumor results.