bluuebunny/crossref_metadata_2025 huggingface dataset:
P02-238 - Neurotropic Activity of Aminoalcohols Based on Glycidylcamphorimide
Authors: Zlenko H. , Kasyan L. , Golodaeva H. , Palchikov V. , Novak O.
Published: June 2010

The present work deals with neurotropic activity of three novel aminoalcohols C-81, C-78 and C-115, synthesized from glycidylcamphorimide, exo- and endo-aminomethylnorbornenes and aminoethyladamantan (remantadin). Experiments have been carried out on both genders adult white mice at the dozes of 1/10 LD50. Acute toxicity of compounds (LD50) has been measured by Litchfield & Wilcoxon method in Prozorovsky V.B. modification and amounts 803 – 1196 mg/kg for C-81, C-78 respectiverly (they are considerably less toxic than exo- and endo-aminomethylnorbornenes, LD50 for which amounts 335 and 331 mg/kg). The most toxic compound is aminoalcohol C-115 with adamantane fragment (LD50 370 mg/kg). Investigation of analgesic activity has been carried out by determination of pain threshold by thermal irritation method (hot plate) at 55°C. Anticonvulsive activity has been studied by corazole spasm test. Tranquilizing activity of preparations was studied by the test of barbituric sleep duration increase caused by hexenale prepared ex tempore (60 mg/kg). Antihypoxic activity was investigated using the closed space model by mice lifetime duration. The activity has been calculated in percentage in relation to control group of animals. All aminoalcohols by all types of activity essentially surpass initial amines. For exo-aminoalcohol C-81 the most intense activities are analgesic (+195.0%) and tranquilizing (+102.3%), and for endo-isomer C-78 - anticonvulsive activity (+213.3%). Levels of antihypoxic effect of aminoalcohols C-115, C-81 and C-78 amount 16.0, 42.0 and 47.5% accordingly. Compound C-115 shows medium analgesic activity (67.1%), and on all other parameters considerably concedes aminoalcohols with a norbornene fragment.
P03-08 - Perceived Psychological Burden of Multiple Sclerosis on Primary Caregivers
Authors: Assimakopoulos K. , Karanasios P. , Argyriou A. , Iconomou G. , Giannakopoulou F. , Makris N.
Published: June 2010

Objectives

Primary caregivers are more likely to have a higher risk of depression and a lower quality of life (QOL). Multiple sclerosis (MS) can adversely affect the psychological and physical function of patients as also of their caregivers. Our aim was to assess the perceived psychological burden and QOL in a sample of primary caregivers of patients with MS under natalizumab treatment.

Methods

20 males and 10 females primary caregivers (mean age 50.6±12.9 years) of an equal number of patients with MS completed the Greek validated version of the Hospital Anxiety and Depression Scale (HADS) and the EuroQOL (EQ-5D), an instrument measuring health outcome and QOL.

Results

Our sample experienced higher degree of anxiety than depression. The mean score on the 7-item HADS-A subscale (range 0-21) was 10±3.8 and the mean score on the 7-item HADS-D subscale (range 0-21) was 7.8±3.4. Twenty-one caregivers were diagnosed as manifesting anxiety (7 mild/14 moderate anxiety), whereas 13 of them also had depression (5 mild/8 moderate depression). The increased psychological distress was supported further by the responses on the anxiety/depression dimension of health of the EQ-5D. Sixteen persons reported moderate and 5 extreme degree of anxiety/depression. Mean EQ-VAS scores were 60.2±14.5 (range 40-100). Ten caregivers rated their health status with a score of 50 or lower.

Conclusions

Our study revealed that caregivers of patients with MS are psychologically burdened in a significant degree, a fact that obviously deteriorates their QOL. Appropriate psychopharmacological interventions are warranted to reduce caregivers’ burden.
P03-10 - Psychological Impact of Chemotherapy Induced Alopecia
Authors: Baati I. , Mnif L. , Masmoudi J. , Allouche C. , Damak R. , Halwani N. , Feki A. , Ayadi N. , Jaoua A.
Published: June 2010

Objectives

The aim of this work was:

•

to understand and measure the emotional effects of chemotherapy-induced alopecia by exploring self-esteem, body image, anxiety and depression in cancer patients

•

to analyse the strategies used to cope with hair loss.

Methods

This was a cross-sectional study. It involved the use of a questionnaire with patients from the medical oncology unit of the Habib Bourguiba University Hospital. The questionnaire included Socio-demographic data, type and stage of cancer, data concerning the alopecia (partial or total) and its impact on social life, work, and sexuality.

Four measurement scales were used:

-

Rosenberg's Self-Esteem scale,

-

Bruchon-Schweitzer's Body image questionnaire (QIC)

-

Hospital Anxiety and Depression scale (HAD)

-

Brief cope

Results

Preliminary study

It was a population of 24 patients. 55.2% were males. The mean age was 45.9 years. 75.9% were married.

Alopecia was the most distressing side effect of chemotherapy in 30.4% of cases. 45.8% were suffering from the stigma of the alopecia which disturbed their social interaction. It led to a loss in self-confidence in half of patients and altered sexuality in third. Self-esteem was low in 34.5%.

The average score of the scale body image was 61. 41.4% of patients were anxious and only 27.6% were depressed.

The religion was the major strategy used to cope with alopecia.

Conclusion

The findings suggest that the chemotherapy-induced alopecia has the potential to affect various aspects of patient's life, but Tunisian cancer patients seems to be less affected compared with literature.
P03-14 - A Quasi-Experimental Controlled Intervention to Reduce Violence on an Acute Psychiatric Ward
Authors: Beezhold J. , Williams P. , Taylor J. , Harris A. , Kandasamy S.
Published: June 2010

Introduction

Violence and aggression are a major concern in acute inpatient psychiatric wards. Hard outcome data on the impact of service change are scarce. This poster presents the outcomes of service changes designed to improve the acute ward environment and patient experience.

Aims and objectives

To implement changes to the delivery of acute inpatient psychiatric services and to measure the outcome of these changes in objective verifiable form.

Method

Significant changes were introduced to an acute psychiatric inpatient service. These included introducing a dedicated inpatient psychiatrist “hospitalist”, replacing weekly ward rounds with daily multidisciplinary care and discharge planning meetings and promoting increased roles for nursing staff in decision-making and patient contact. Outcomes measured included routinely recorded incidents of violence with and without injury, use of restraint for medication and use of constant nursing observation. The control group was a similar service in the same hospital subject to the same general policies and admitting patients demographically comparable, but that did not at the time undergo the interventions implemented in the trial service. All data was recorded by staff who were unaware of this study or even that any analysis of the data would occur.

Results and conclusions

Violent incidents in the intervention ward dropped by 34% per patient (p=< 0.02) whilst increasing by 3% in the control ward; restraints decreased by 28% (p=ns) whilst increasing by 12% in the control ward; with an overall reduction in constant observation. The intervention was highly effective in reducing violent incidents.
P02-240 - Personality Factors Related to Emerge of Stress in University Students
Authors: Aghajanipour H. , Homayouni A.
Published: June 2010

Objectives

The study aimed to investigate relationship among personality dimensions (introversion-extroversion E/I, intuition-sensing N/S, thinking-feeling T/F, perceiving-judging P/J) based on Jungian personality types and stress in university students.

Methods

200 students of university were randomly selected and Hogan-Champagne's Personal Style Inventory (PSI) and Coudron's Stress Inventory (CSI) were administered on them. The PSI assesses eight personality dimensions based on Jungian personality types mentioned above. The data were analyzed with Pearson correlation coefficient.

Results

Findings showed significant positive correlation between introversion and stress and significant negative correlation between extroversion and stress. In addition, more analysis of personality dimensions showed female are more sensing than male and male are more intuition than female.

Conclusions

In regard to introverted are independently constraints and prodding from situation, culture, people, or things around them, so facing to stress factors interrupt their own world and reduce their function, cause to variability in situation and stress emerge.
P02-243 - Neurocognition and Temperament in Borderline and Schizotypal Personality Disorder
Authors: Berlin H.A. , Hamilton H. , Rogers K. , Goldstein K.E. , Siever L.J. , New A.S. , Hazlett E.A.
Published: June 2010

Objective

Explore the neurocognitive and temperament profile of borderline personality disorder (BPD) and schizotypal personality disorder (SPD) to better understand their underlying neurobiology for improved treatment.

Methods

17 BPD, 16 SPD, and 15 healthy controls (HCs) were given a comprehensive neuropsychological battery (CANTAB), the Iowa Gambling Task, a time perception task, and questionnaires of impulsivity, temperament, emotion, and frontal behavior (measures orbitofrontal cortex (OFC) dysfunction).

Results

BPD and SPD patients performed significantly worse on the delayed match to sample (DMS) task compared to HCs, but had preserved function on decision-making, planning, time perception and attention tasks. SPD patients performed significantly worse on spatial working memory (SWM) tasks, and had higher religious commitment scores than HC and BPD groups, which correlated with their SWM deficits. BPD patients had significantly more frontal behaviors and emotions than both groups, which correlated with their emotionality, impulsivity, BPD symptoms, and temperament traits.

Conclusions

Both BPD and SPD groups had a deficit on the DMS task, sensitive to medial temporal lobe (MTL) dysfunction, but only SPD patients had SWM deficits, indicative of dorsolateral frontal cortex (DLFC) dysfunction, which correlated with their high religious commitment in line with their odd beliefs and magical thinking. Only BPD patients had frontal behavior deficits, related to OFC dysfunction, which positively correlated with their emotionality, impulsivity, and temperament traits. While both disorders may have a deficit in MTL function, DLFC dysfunction may contribute to SPD symptoms, and OFC dysfunction to BPD symptoms, suggesting treatment should target unique prefrontal cortex regions respectively.
P02-246 - Factors Predicting the use of Internet at Work for Non-Work Purposes for a Random Sample of Company Workers in Greece
Authors: Frangos C. , Frangos C. , Sotiropoulos I.
Published: June 2010

Indroduction

Internet is an important means of communication but its use must be monitored to prevent inefficiency in the working places and to become a behavioral disorder for workers.

Objectives

The aim of this paper is to investigate the relationships between the use of Internet at work for non-work purposes (Cyberloafing) and factors such as gender, age, years of work at company, education, excessive use of Internet at home, company salary and certain psychological attitudes such as loneliness and lack of self-esteem.

Methods

A random sample of 409 workers (180 men, 229 women) was interviewed using a questionnaire with demographics, applications of Internet and Young's criteria of Internet addiction sections. We performed a binary logistic regression analysis using the SPSS 18 with depended variable the amount of time spent every day on using the internet at work for non-work purposes.

Results

The following factors were found statistically significant predictors of the depended variable. Sex, Length of time for viewing Sports news at work, General Information, Buying pages, Playing games and Gambling. The mean age of the Cyberloafers was 35 years and the percentage of the workers who could use Internet at work for non-work purposes was 9.1%. The percentage of men who were using Internet at work for non-work purposes was 12.2%, whereas the analogues percentage for women was 6.6%.

Conclusions

Specific steps of monitoring the Internet use and organizing companies seminars for avoiding the dependence on the internet are recommended for maximum efficiency.
P02-260 - Sociocultural Pressure, Body Dissatisfaction and Disordered Eating in Female French Students
Authors: Rodgers R. , Valls M. , Faure K. , Chabrol H.
Published: June 2010

Objective

To examine the association between sociocultural pressures, body dissatisfaction and disordered eating among female French students.

Method

Participants were 201 women from a Toulouse University (mean age=20.70 years, SD=2.56). Pressure perceived from the media, peers and parents was assessed using parallel scales. The questionnaire also assessed body dissatisfaction (BD), drive for thinness (DT), bulimia (BU) and self-reported height and weight.

Results

Participants reported higher scores of peer pressure (mean= 6.87, SD=1.82), than media pressure (mean= 6.14, SD=2.32) and parental pressure (mean= 5.41, SD= 1.44). The difference between the pressure perceived from each source was significant (p< .001). BD was significantly correlated with pressure from the media (r= .25), peers (r= .19), and parents (r= .21). DT was also significantly correlated with pressure from all three sources (r= .21; r= .25 and r= .17 respectively). BU was significantly correlated only with media pressure (r= .16). Hierarchical regression revealed that BMI, and sociocultural pressures, accounted for 38% of the variance in BD F(4, 190)= 28.63, p=< 001, with BMI, media and parental pressure as predictors. BMI, media and peer pressure were predictors of DT F(4, 190)= 28.26, p=< 001, R2=21. BMI and media pressure were predictors of BU F(4, 190)= 6.41, p=< 001, R2=12.

Discussion

Sociocultural pressure contributes strongly to body image and eating concern among French students. These findings highlight the importance of developing sociocultural models among French populations, and the need for prevention interventions that build on these frameworks.
P02-261 - Efficacy of Psychotherapies for Borderline Personality Disorder - a Meta-Analysis of Randomized Controlled Trials
Authors: Stoffers J. , Völlm B. , Lieb K.
Published: June 2010

Introduction

Psychotherapeutic therapies play an important role in borderline personality disorder (BPD) treatment. Pharmacotherapy can be helpful for some symptom clusters, but overall psychotherapy remains the most promising approach to treat persons with BPD. In the last two decades, disorder specific psychotherapeutic approaches have been developed and evaluated.

Aims

To systematically identify, integrate and review the current evidence on treatment efficacy using systematic Cochrane Collaboration review methodology.

Methods

Thorough literature searches were done to identify all available randomized controlled trials (RCTs) on psychotherapy in adult BPD patients. Retrievals were assessed by two reviewers independently in terms of matching the inclusion criteria and fulfilling a pre-defined study quality standard. Data were analyzed according to standards of the Cochrane Collaboration. Outcome variables were BPD pathology, associated psychopathology, and treatment compliance in terms of attrition.

Results

Included RCTs comprised both comparisons of specific treatments (among others, dialectical behavior therapy, mentalization-based therapy, schema-focused therapy, transference-focused therapy, systems training for emotional predictability and problem solving, interpersonal therapy) vs. unspecific control conditions (such as treatment as usual or standard care) and head-to-head comparisons of specific treatments.

Conclusions

Most beneficial effects were found for BPD-specific psychotherapies, whereas effects of non-specific treatments were marginal. Short-time interventions yielded some promising findings, but sustainability remains questionable. Findings will be discussed in terms of evidence robustness and data quality as well as applicability to real-world settings.
P02-265 - Mind and its Trouble as Aspired by the Century old Philshopers and Saints in India
Authors: Acharya A.
Published: June 2010

Introduction

Mind and it's role in human growth and devoloptment & it's different layers are always an arena of great interest to the ancient philoshopers as well as the religious teacher of ancient India. In different religios sector in Hinduism or in Budhism mind and it's control was a key factor in attaining the bliss or the enlightment.

Objectives

Here we examine some of the relevant philoshophical doctrines that may be applied/amalgamated with our modern pharmacology and therapy in a benefecial way. For the peace, calmness, attaining tranquility in distubed mind our approach may be hollistic with blending the aroma & flavour of those great philoshopers analysis on mind & their ways to derived a peaceful state in a restless mind.

Aims

it will be to beneficialy tuned the philoshophers insight into our modern way of management.

Methods

Here we willcite a few philoshopers connocation derived from GITA of Hinduism & from Budhist Philoshophy. According to Budda “…attachment is the root of all evils inmind…”. An non attachment theory or a non meself doing the things keeps the mind free. The 4 noble truth preached by Lord Budda are

1)

There is sorrow in life.

2)

there is cause for this sorrow or disrurbed state

3)

there is way for remedy of this.

4)

thatremoval of sorrow or non-peace is possible in life.

In Bhagbat GITA In karmay yog all works are directed to perform in a non ““I” state.

Calmness of mind could be achieved by “Practice” (meditation) & Dispassionate.

Conclusions

Philosophical aspects of mind will enrich our knoweledge.
P02-267 - How to Hold Happiness & Increase Efficiency in Life
Authors: Acharya A.
Published: June 2010

Introduction

Quest of happiness in life is time immortal. Meaning of happyness do differ from region or country & culture to culture. Still the search for happiness in life is universal & a goal that can be achived easily, specialy in the outlook of eastern philoshophical doctrine.

Objectives

Happiness and peace of mind is out of out an inner thing, contained in each person. Only it's expression or realisation needs a practice, positive thinking attitude & positive lifestyles.

Happyness as such cannot be imported from any outside agency, or a person, that beutiful women, or a nice hanging decorating balcony on the opposite pavement.

Aims

Through rays onthe path that can increase output & efficiency in life.

Methods

3 practical way may bring happyness readily;

1.

Good thoughts, encouraging thoughts, positive thougts, positive attitude & life doctrine.

2.

Good works--meaning works that supports or serve others, that please others.& not irks others, not violate thier rights rather works that brings joys in other life sphere.

3.

Good behavior. Any moment it will not be a unpleasent behavoir or a behavior that will not brings us close.

Satisfaction with the little we have achieved.

What are the obstacles to the path of happiness?

“attachment is the root of all evils” was sais by lord budha.

Any attachment to property, to person, or even to self will desttroy happyness, by imparting expectatios & unfulfillment of desires borneout of expectation.

Dispassionate (“Vairaggya”) and non-attachment will make us free.

Results

A selfness vision, works not done by me rather by thou.

Conclusions

Non-attachment & passionless living means happyness.
P02-271 - Psychiatric Trainning as a “Rite of Passage”: a Field Study in Spain
Authors: Calero-Fernández R. , Serrano E. , Magariños M. , Picazo J. , Peláez C. , Fernández L. , Martín M.J. , García I. , Carmona R. , Caballero-Martínez L.
Published: June 2010

Background

“Rite of passage” is an etnographic concept developed by VanGennep that defines the vital transition of an individual between two different status. It is divided in three stages: separation, liminal/threshold and aggregation. Turner described the liminal phase, and the terms of “communitas” and “liminoid” (structure of a rite without religious/spiritual elements). One widely-known Rite of Passage is the initiation of the shamans.

Objetives

Study the elements of a rite of passage present in Psychiatric Trainning.

Method

•

Field study (observational, descriptive, non-experimental).

•

Preliminary Sample=10trainees (5man+5women); last year of Psychiatric Trainning.

•

“ad hoc” semi-structured interview (21items subdivided in open questions). 10interviews (average duration=75mins). Permanent register:digital recorder.

•

Summary and analysis of the answers. Review of the literature.

Results

-

Psychiatric Trainning shared the elements and tri-phasic structure of VanGennep's “rite of passage” concept

-

Trainees saw themselves as more empathic(7/10) and humanistic(8/10) than other specialties colleagues. Stigma towards mental illness(8/10) and fear of suicide(9/10) were also considered as their distinctives.

-

The collective behaved as a communitas(10/10)

-

No spiritual elements(0/10): liminoid process

-

Resemblances of the ancestral shamans' Initiation: Despite bloody practices were over, suffering was also present(7/10), but was seen as necessary(6/10) and well tolerated(7/10).

-

Trainees felt that they grew spiritual and mentally(7/10) during the trainning years

Conclusions

Results suggest that Psychiatric Trainning has stable phenomena that:

•

are compatible with the Rite of Passage schema

•

Are considered exclusive of Psychiatry by trainees

•

Have not been systematically studied as a whole, which could help to improve the training.
P02-275 - Early Prevention of Mental Disorder is the Key in Keeping Good Mental Health
Authors: Acharya A.
Published: June 2010

Introduction

Keeping and maintaining mental health in a community or at a large in a soceity is a difficult,but promising task.Mental health is a dynamic state as that of state of health which is also going to be redefined than a state of complete physical, mental and soceial health. A positive mental health is not merely absence of any mental disorders, rather a flourishng environment where an individual can grow,work, and fulfil his dreams & aspiration & also nurcher own imagination in a fruitful manner.

Objectives

Here it was a comparism between a rural and a community catchment area of 2 different places and mental health questionories were distributed among 2 high scool students who are derived fom 2 different socioeconomic status.

Methods

50 male & 50 female student of 2 catchment area in rural,as well in city school were collected in same proforma.Facilities in village school includes large playing ground,more joint family stucture & more choseveness.In city per capita income, library facility, playing facility,rcreationalsopes are more flourishly arranged.Mental disorders noted are early diagonosed and early intervenation done in city school.In rural scools all 12 known cases of some mentaldisturbances were takencare of in late.

Results

From the questinary itself, from the reports of teachers and fellow student it shows mental health is more in positively maintanned state in city environment scools, as well early diagnosis & care.In rural settings good library and liberal friend ship & chosive pattern of family & soceity helps.
P02-280 - The Combination of Amisulpiride and Clozapine for the Treatment of Treatment-Resistant Schizophrenia
Authors: Istikoglou C. , Foutsitzis D. , Papouli F. , Polonifis N. , Kanellos P. , Theodorakopoulos G. , Kogeorgos J. , Vlissides D. , Michelidakis K. , Salla T.
Published: June 2010

Objectives

Treatment-resistant schizophrenia is an old term, describing the form of schizophrenia that does not respond to a treatment dose of Chloropromazine, equal to 1,5 gr.

Methods

20 (n=20) patients have been studied, that were diagnosed with schizophrenia, and did not respond to any combination of typical or non-typical anti-psychotic drugs. These patients were 19-62 years of age, and were administered the BPRS and PANSS scales at start of the examination or the hospitalization, and during the 1st, 3rd, and 6th month evaluation. The said patients were treated with a combination of Amisulpiride, and Clozapine.

Results

The patients received a dosage range of 400-1200mg for the Amisulpiride, and 300-900mg for the Clozapine. 18 patients (90%) responded to this treatment, and showed an improvement in the BPRS and PANSS scales, from the 1st month of treatment using a combination of Amisulpiride-Clozapine. Later, during the 3rd month of treatment, one of the patients discontinued the treatment, as she presented leucopenia (white cell count: 3250). The discontinuation of Clozapine treatment was decided. Clozapine was replaced by 20mg Olanzapine.

Conclusions

Despite the fact that the sample of patients was very small (n=20), it seems that the combination of Amisulpiride and Clozapine is effective for the treatment of patients showing resistance in pharmaceutical treatment and the combination of typical and non-typical neuroleptics.
P02-283 - Psychotic-Like Experiences, Emotional and Behavioral Problems in Nonclinical Adolescents
Authors: Paino M. , Fonseca-Pedrero E. , Lemos-Giráldez S. , Sierra-Baigrie S. , Villazón-García U. , Muñiz J.
Published: June 2010

Approximately 5 % of adolescents present psychotic symptoms which are not necessarily associated with a psychopathological alteration and that are known as subclinical psychotic-like experiences. Said symptoms have been found to be closely linked to the presence of affective psychopathology, such as high levels of anxiety, stress, dysphoria or depression in this population.

Objectives

The main objective of this work was to compare the emotional and behavioral problems reported by adolescents with and without psychotic-like symptoms.

Method

The sample was composed of 1,713 non-clinical adolescents with a mean age of 14.7 years (SD = 1.7), of which 832 (48.6 %) were males.

Results

The results showed that the participants with psychotic-like symptoms reported a higher number of emotional and behavioral problems compared to the participants who did not inform of said experiences.

Conclusions

The findings converge with data from previous studies of patients with schizophrenia as well as in schizophrenia-prone individuals, offering support to the dimensional models of psychosis, and have clear implications with a view to establishing primary prevention strategies for these high-risk individuals.
P02-284 - On-Going Real Life Applications in Mental Health Prevention and Promotion Among Young Adults: Bringing Elders and Youth Together for Healing
Authors: Lloyd R.
Published: June 2010

Objectives

This paper outlines evidence from field work conducted in Sydney (a large capital city on the southern east coast of New South Wales, Australia) and in Alice Springs (a small town located in Central Australian desert in the Northern Territory, in the heart of Australia), among young adults living with mental distress. It aims to explore the efficacious effects of bringing young and elders together, in unconditionally supportive communities of belonging, providing mirroring and feedback in the journey of recovery and growth for both groups.

Methods

The paper applies case study profiling and autoethnographic practitioner reflection on work conducted between 2004-2009, in a PhD field group of 60 participants in an “open urban tribe”; and among all ages of the community involved with headspace youth mental health project in Alice Springs.

Results

The paper describes positive impacts on both age groups from sharing in the practice of “working the business of life” together - in the indigenous sense of giving feedback, humour, witnessing and testimony, about individual's life choices.

Conclusions

The evidence arising from this work is that sharing perspectives, experiences, fears and triumphs, in environments of trust and safety, can lead to strengthening and growthful outcomes for all ages. The paper concludes that combining people of diverse ages, cultures and consciousnesses can have efficacious effects on all involved. This leads to further evidence for the author's All Fruits Theory, akin to Queer Theory only referring to diversity in consciousness rather than gender preference.
P03-315 - Pisa Syndrome in a Patient Using Ziprasidone - a Case Report
Authors: Steiner A.B. , Steiner O.
Published: June 2010

Objective

Atypical antipsychotics are used in large scale in reason of their few side effects, as extrapyramidal symptoms. Dispite of this safety they can cause severe dystonia as Pisa Syndrome.

This case brings an example of Pisa Syndrome induced by the use of Ziprasidone.

Methods

A thirty five year old female, diagnosed with Bipolar disorder was treated in a psychiatry ambulatory with lithium 1200mg and haloperidol 10mg. As the psycosis persisted it was necessary to change the antipsychotic and ziprasidone was chosen.

Three months after the introduction of ziprasidone, the patient began to present severe dystonia symptoms. In the occasion could be noticed sustained involuntary flexion of the body and head to one side as well as slight rotation of the trunk.

Results

In reason of the extrapyramidal symptoms, ziprasidone was suspended.

The case was treated with anticholinergic drugs. Prometazine and biperidene were tried but neither was effective.

Two months after the suspension of Ziprasidone the patient recovered completely and did not present any signs of dystonia.

Conclusions

Pisa Syndrome can be caused by atypical neuroleptics as ziprasidone.

The treatment is difficult and anticholinergics are not effective.

In some situations Pisa Syndrome can be definitive.

The use of atypical antipsychotics requires knowledgment and experience from the psychiatrist. The potencial of atypical antipsychotics to cause extrapyramidal symptoms as Pisa Syndrome can not be forgotten.
P03-317 - Agomelatine Facilitates Benzodiazepine Discontinuation in Schizophrenia with Severe Insomnia
Authors: Morera-Fumero A.L. , Diaz-Mesa E. , Abreu-Gonzalez P. , Henry M. , Yelmo S. , Fernandez-Lopez L. , Gracia-Marco R.
Published: June 2010

We present the case of a schizophrenic patient with severe insomnia that had a partial response to high doses of benzodiazepines and sedating antipsychotics. Treatment with agomelatine allowed to suspend benzodiazepine treatment and restore quality of sleep.

Case report

Mr. Y is a 36 year old male patient diagnosed with simple schizophrenia that has complained of insomnia since the age of sixteen. During the last three years the treatment that the patient was following was stable and consisted of 100 mg of diazepam, 300 mg of levomepromazine and 120 mg of clotiapine every night. During the last year 60 mg of duloxetine were added to treat a moderate depression. His mood improved with the prescribed treatment, but eleven months later it worsened. In an attempt to simultaneously treat the mood and the sleep disorder, during a period of 4 days, a dosis of 12.5 mg of aglomelatin at dinner was introduced while the morning dose of duloxetine was reduced to 30mg. On the fifth day, agomelatine was increased to 25 mg at dinner while duloxetine was suspended. The antipsychotic treatment was kept stable while the patient was instructed to reduce 10 mg of diazepam every week until next appointment one month later. In the next appointment the patient had completely suspended diazepam one week before the appointment. The patient referred improved sleep quality and no rebound insomnia.

Conclusion

Agomelatine may be a valid treatment of insomnia in schizophrenia.
P03-324 - Clinical Remission in Schizophrenia Patients Treated Wiht Ziprasidone for up to One Year
Authors: Campos Mangas M.C. , Ruiz Feliu M.A.
Published: June 2010

Introduction

Schizophrenia is a debilitating and cronic disease for which full recovery is typically not considered to be a realistic treatment endpoint. Symptomatic remission, however, may be an objectively attainable treatment goal.

Obtectives

We wanted to assess remission rates over 52 weeks in patients with schizophrenia treated with ziprasidone

Methods

Remission rates were calculated using data from a 52 week study in which patients diagnosed with acute schizophrenia were stabilized with ziprasidone (n=30, dose 120-140mg/day) For this analysis, remission was operationalized according to the consensus-based symptomatic remission criteria established by the Remission in Schizophrenia Working Group. Accordingly, patients were required to achievescores Syndrome Scale (PANSS) items (delusions, unusual thought content, hallucinatory behavior, conceptual disorganization, mannerisms/posturing, blunted affect, social withdrawal, lack of spontaneity) and to maintainthe item score threshold for at least 6 consecutive months.

Results

Thirty-seven percent of ziprasidone treated patients satisfied the criteria for symptomatic remission within the 52-week trial period. Approximately 7% of patientslost their remission status prior to the end of thetrial, with mean time in remission of 6.5 months. Forty-six percent of patients never met the PANSS item threshold. During the 52-week study, few patients discontinued due to adverse events other than worsening of symptoms(7%) or received concomitant medication for EPS (18%)

Conclusions

Nearly one third of the patients treated with ziprasidone achieved remission status within 6 months. Most patients who achieved remission remained in remission for more than 9 months until trial termination. Overall CGI-Is of these patients were significantly better than for patients without remission.
P03-325 - Functional and Symptomatic Improvement in Adults with ADHD - Data from the Open Label Extension of the Lamda Trial
Authors: Casas M. , Trott G.-E. , Kooij S. , Ramos-Quiroga J.A. , Dejonckheere J. , van Oene J. , Schaeuble B. , Buitelaar J.
Published: June 2010

Objective

To explore the relationship between symptomatic and functional outcomes in adults (age 18-65 years) with ADHD during open label treatment with PR OROS MPH.

Methods

Post hoc analyses of a 7-week open-label extension (OLE) (N=370) of a 5 week, placebo controlled double-blind study (DB) which explored safety, efficacy, functional and quality of life outcomes in subjects with a diagnosis of ADHD (DSM-IV). Medication was flexibly dosed (18-90 mg/day) and adjusted individually to best effect during OLE. Regression analyses were performed on the change from DB baseline at OL endpoint in functionality and quality of life as measured by the Sheehan Disability Scale (SDS) and Quality of Life (Q-LES-Q). Baseline score, country, randomization group, sex, change from baseline in CAARS Hyperactivity / Impulsivity, CAARS Inattention and CGI-S at DB endpoint were included as covariates in the analyses.

Results

337 / 370 patients completed the 7-week open label treatment. Improvement on CAARS Hyperactivity / Impulsivity at DB endpoint was significantly related with improvement in SDS “work”, “social life”, “family life” (at least p< 0.005) and “total score” as well as quality of life (p< 0.05) at the end of open label treatment. Change in CGI-S and CAARS Inattention at DB endpoint vs. DB baseline were not related with improvements in any of the functional or quality of life scales at OL endpoint (p>0.05).

Conclusion

These results indicate that improvement in daily functioning and QOL under active treatment may be particularly related to improvement in hyperactivity symptoms.
P03-327 - What About Dosing Olanzapine Plasma Concentration in Mania? Plasma Threshold Determination
Authors: Denizot H. , Blanc O. , Libert F. , Dubray C. , Schwan R. , Llorca P.-M.
Published: June 2010

Objectives

Olanzapine plasma concentration ≥ 23, 2 ng/ml have been identified as a predictor of clinical response in acutely ill patients with schizophrenia. Aim was to determine relation between plasma concentration of olanzapine in a sample of inpatients or outpatients with acute mania by defining a plasma threshold (above which a better clinical response was obtained).

Methods

Open label, longitudinal, multicentric study including patients with acute mania and treated by olanzapine for 6 weeks; plasma concentration of olanzapine was measured at 3 and 6 weeks by high-performance liquid chromatography. Patients were considered “responsive” if they showed at least a 50% reduction in Young Mania Rating Scale score and a Clinical Global Impression Severity scale score of ≤ 3.

Results

Twenty patients were including (13 men and 7 women), mean age 57.4 yr. The mean olanzapine dosage was 11.46 mg/day (SD=2.49) at the same dosage for 16.8 days (SD=6.5). Receiver operating characteristic curve analysis determined a plasma threshold to be 15, 9 ng/ml.

Conclusions

It's the first time that a threshold of Olanzapine is determined in bipolar mania into a consequent population. This result could be considered as additional tools to adjust posology for improve cares, when manic patients are resistant.
P03-335 - Clinical Controlled Study of Venlafaxine and Fluoxetine in Treatment of Obsessive-Compulsive Disorder
Authors: Liu H. , Ji C. , Xiao W. , Wang G.
Published: June 2010

Objective

The aim of this study was to compare the clinical efficacy and the safety of venlafaxine and fluoxetine in the treatment of obsessive-compulsive disorder (OCD).

Methods

One hundred and Eight inpatients who met the Diagnostic and Statistical Manual of Mental Disorders, the Forth Edition(DSM-IV) for OCD were involved in this study. The subjects were randomly divided into venlafaxine group or fluoxetine group. Efficacy of venlafaxine and fluoxetine in treatment of OCD were assessed with Yale-Brown Obsessive Compulsive Scale (Y-BOCS) and Clinical Global Impression-Severity(CGI-S), the side effects were evaluated with Treatment Emergent Symptom Scale (TESS).

Results

The therapeutic efficacy in venlafaxine group was similar to that in fluoxetine (70.36%vs68.29%, P>0.05) after eight weeks’ therapy. The improve-rates of Y-BOCS after 2 weeks’ therapy of venlafaxine were significant higher than those of baseline, while the improve-rates of Y-BOCS after 4 weeks’ therapy of fluoxetine were significant higher than those of baseline(P< 0.05). The side effects of venlafaxine group were similar to fluoxetine group (P>0.05).

Conclusion

The results indicate that both venlafaxine and fluoxetine is effective in the treatment of OCD, but venlafaxine work faster than fluoxutine.
P03-337 - Escitalopram in Treatment of Poststroke Depression
Authors: Havle N. , Altunkaynak Y. , Dayan C. , Ilnem M.C. , Arpaci B.
Published: June 2010

Objective

Poststroke depression (PD) occurs in approximately one third of the patients within first two years of a cerebrovascular event. However, no definite consensus has been reached on the best treatment option. The aim was to determine the efficacy and safety escitalopram, a selective serotonin reuptake inhibitor, in PSD treatment.

Methods

Patients with symptoms of depression within 6 months of a cerebrovascular event were included. Patients with Hamilton depression (HAM-D) score of < 13, mini mental standardized test score of < 23, schizophrenia, behavioral disorders, substance abuse, history of alcoholism, current use of antidepressants, and history of stroke or major depression within the last one year were excluded. Patients were administered escitalopram 10 mg/day for 3 months. HAM-D scores, stroke severity and extent of functional impairment were assessed and side effects were recorded; the relationship between HAM-D scores and sociodemographic variables and stroke localization was investigated.

Results

Totaly,35 patients (60% female; mean age, 67± 6) were included. Depression was diagnosed 3±1.2 months after the stroke. HAM-D scores decreased significantly in all visits (days 15, 30, 45 and 90). The mean HAM-D score decreased from 27.5±4.7 to 4.65±2.47 at day 90 (p< 0.0001). No significant correlation was found between HAM-D scores and cerebrovascular event localization, sociodemographic variables and medical history (p>0.05). Escitalopram was well tolerated. A total of 9 patients reported nausea, anxiety, drowsiness and dyspepsia.

Conclusion

In this open-label study escitalopram was found to be safe and effective for use in poststroke depression patients.
P03-343 - Treatment Choice in Psychiatry? How Would European Trainees Treat Psychosis for Their Patients and Themselves, and what Influences Decision-Making?
Authors: Jauhar S. , Guloksuz S. , Gama Marques J. , Bendix M. , Lydall G. , Andlauer O. , Gerber S. , Roventa C. , Van Zanten J. , De Vriendt N. , Nawka A. , Nwachukw I. , Dobrzynska E. , Mufic A. , Nazaraliev A. , Dumitrescu I. , Mendonca L. , Riese F. ,   European Federation of Psychiatric Trainees (EFPT) Research Group
Published: June 2010

Objectives

Recent evidence has questioned modern psychiatric clinical practice, specifically the prescribing of “atypical” antipsychotics. Our Pan-European Research Group wished to ascertain clinical practice amongst European trainees, which treatments trainees would desire for themselves, and factors influencing this.

Methods

A semi-structured survey was constructed from prior literature, piloted, and a homogenous sample size of at least 50 was agreed upon from each country, with 50% minimum response rate. It was distributed via web-link, with questions on preference of antipsychotic for patients in given scenarios, and factors influencing choice. Physicians were asked for their preference should they develop psychosis.

Results

i)

Treatment choice of antipsychotic for patients

93% (n=600) of respondents chose to prescribe “atypical” antipsychotics (excluding Clozapine), 6% (n=42) choosing “typical” antipsychotics, 1% (n=6) choosing Clozapine as first-line therapy.

ii)

Treatment choice if trainees developed psychosis

89% (n=530) of responders chose to prescribe “atypical” antipsychotics (excluding Clozapine), 7% (n=40) choosing “typical” antipsychotics, 4% (n=23) choosing Clozapine as first-line therapy.

iii)

Factors influencing choice

These mapped onto three domains: cost, efficacy and side-effect profile (less than 5% other reasons). 79% (n=458) of those who responded felt efficacy most important, 46% (n=270) felt side-effect profile most important and 3% (n=16) considered cost of paramount importance.

38% (n=272) of those who responded to the survey stated that the CATIE trial had influenced their decision-making.

Conclusions

Psychiatry trainees’ choice of antipsychotic medication for both patients and themselves is based on perceived benefits, as opposed to evidence base and recent literature.
P03-344 Epileptic Seizures Associated with Quetiapine use: Report of two Cases
Authors: Karslioglu E. , Manisali Erkek B. , Peker S. , Ulusoy Kaymak S. , Özalp E. , Cankurtaran E. , Soygür H.
Published: June 2010

Approximately 1.7% of all epileptic seizures are induced by drugs, mostly psychotropics. Although the risk is known to be the lowest, a few reports notified quetiapine-induced epileptic convulsions. We report two additional cases.

Case 1

Twenty-five-year old man suffering from paranoid psychosis was given quetiapine for persisting symptoms. He also had myoclonic disorder which has become worse just after administering quetiapine. Physical, neurological and laboratory findings were normal. He once had a generalized seizure in our clinic. The electroencephalography (EEG) revealed an epileptic focus on frontal region. He has been diagnosed as frontal lobe epilepsy exacerbated by quetiapine. He has recovered and was doing well after withdrawn the drug.

Case 2

Twenty-three-year old women who had bipolar disorder was hospitalized due to a manic episode. Physical examination and routine laboratory tests were normal. Lithium at 600mg/d and quetiapine at 300 mg/d were started. Quetiapine has been gradually increased up to 900 mg/d at which the myoclonic symptoms first noted. They were disappeared after quetiapin was tapered to 600 mg/d. To control manic symptoms, quetiapine dosage had to be increased up to 700 mg/d again, but myoclonus was reappeared. Quetiapin was replaced with risperidon and manic symptoms subsided. No myoclonic seizures were noted during follow-up.

Conclusion

EEG abnormalities particularly likely with clozapine and olanzapine, moderate with risperidone, and the lowest with quetiapine. The risk of quetiapine-induced epilepsy was estimated as 0.75%. Evaluating of patients for the epileptic background is important in selecting proper antipsychotic medication.
P03-346 Effects of Placebo-Controlled Withdrawal After Long-Term Open Label Treatment with OROS MPH in Adults with ADHD
Authors: Kooij S. , Nyrerod H.J. , Casas M. , Dejonckheere J. , Waechter S. , van Oene J. , Schaeuble B. , Buitelaar J.
Published: June 2010

Objective

To explore maintenance of effect with OROS MPH in adults with ADHD.

Methods

Multicenter study randomizing adult subjects with ADHD who completed open-label (OL) treatment with OROS MPH (18-90mg/day) for at least 52-week and consented to a 4-week, randomized, double-blind (DB), placebo-controlled (PLC) withdrawal period. Efficacy measures included total CAARS score, CAARS-S:S, GAE, CGI-S and CGI-C. Endpoint analyses were performed using LOCF.

Results

99/155 patients completed the OL OROS MPH treatment phase, only 45/99 patients consented to double-blind randomization. At DB baseline, mean ± SD TCS was 12.1±5.34 (n=23) in the continued OROS MPH group and 16.5±7.49 (n=22) in the placebo group. CAARS changed from DB baseline to DB endpoint by 4.0±7.61 and 6.5±7.82, respectively (p = 0.2586 between groups). CGI-C scores indicated more worsening of symptoms in the placebo group compared to the continued PR OROS MPH (p = 0.0422). Median (range) GAE scores at endpoint were 2.0 (0-3) and 0.5 (0-3), respectively (p=0.0254). Other efficacy endpoints were numerically in favor of OROS MPH. The randomized withdrawal phase may have been underpowered to show statistical significance between treatment groups for the primary outcome. The incidence of treatment-emergent AEs during the DB phase was comparable between groups.

Conclusions

The results indicate that treatment discontinuation after long-term exposure of adults with ADHD to OROS MPH is associated with worsening of clinical symptoms. Statistical significance for several outcomes was not reached, possibly due to study limitations.
P03-347 Transitioning Onto OROS MPH is Associated with Improved Functioning and Quality of Life in Children and Adolescents with ADHD
Authors: Kordon A. , Hultzsch W. , Mattejat F. , Dichter S. , Schaeuble B.
Published: June 2010

Objective

To explore functionality and quality of life outcomes in children and adolescents with ADHD transitioning from IR MPH, ER MPH or ATX onto OROS MPH.

Methods

Pooled analyses of two similar 12 week open label, flexibly dosed studies including children (6-18 yrs) diagnosed with ADHD (ICD-10) transitioning from shorter acting stimulants or Atomoxetine onto OROS MPH. Connor's parents rating scale, children's global assessment scale and quality of life (ILC, LQ-0-28) were applied.

Results

822 patients (84.9% boys; median age 10 yrs) were analyzed. 81% of patients concluded the study. Starting and final dose was based on physician's judgment. Median dose at baseline and endpoint was 36mg/day. On average, C-GAS ratings improved by 12 points (p< 0.001). The percentage of children showing “variable functioning with sporadic difficulties” at baseline or worse decreased from 57,2% to 43,3% at endpoint. 61% of patients improved by at least 30% on CPRS. The percentage of children meeting educational demands at school at least “rather good” increased from 26,6% to 47,4% at endpoint. Results were similar for “social interaction with other children”, “emotional status”, “occupying with him or herself”. Burden of disease (patients or care givers) decreased (p< 0.001). Improved C-GAS and LQ 0-28 correlated with decreased CPRS. Treatment emergent AEs occurred in 35.6%. AEs ≥ 4%: insomnia (8%), muscle twitches (5%) and anorexia (4%).

Conclusion

Transitioning onto OROS MPH was associated with clinically relevant improvements in daily functioning, aspects of quality of life and decreased burden of disease in patients and their cares.