bluuebunny/crossref_metadata_2025 huggingface dataset:
WEIGHT GAIN AND BREAST CANCER IN PREMENOPAUSAL PHASE OF
WOMEN
Authors: Ansari Firdous
Published: February 2021

Breast cancer (BC) is one of the leading causes of cancer mortality in female in the world. It is the second most common
cancer among Indian women.(1). It is accounted for 25% of female cancer cases at all ages and for a greater percentage
among young women. (2,3).Various studies reported that increased adiposity in childhood and before menopause is inversely associated with the
risk of breast cancer diagnosed at premenopausal and postmenopausal ages, whereas increased adiposity after menopause is positively associated
with risk.( 3-13).Obesity is associated both with a higher risk of developing breast cancer, particularly in postmenopausal women, and with worse
disease outcome for women of all ages(14).In this study we considered copious studies concerning with weight gain and breast cancer in
premenopausal phase of women. Thereafter in the last section of the study conclusion is made.
Discussion: Being a woman is a risk factor for being diagnosed with breast cancer. Studies scrutinized, are reecting that obesity as well as
premenopausal and postmenopausal phases impersonate their signicance in accentuated disease occurrence.
Optical frequency microcomb distillation for super channel data transmission
Authors: Moss David
Published: February 2021

Microcombs provide a
potential compact and efficient light source for multi-Terabit-per-second
optical superchannels. However, as the bandwidth of these multi-wavelength
light sources is increased, this can result in low per-line power. Optical
amplifiers can be used to overcome power limitations, but the accompanying spontaneous
optical noise can degrade performance in optical systems. To overcome this
issue, we propose wideband noise reduction for comb lines using a high-Q
microring resonator, whose resonances align with comb lines. When applying the
proposed distillation to a superchannel system with 18 Gbaud, 64-QAM
sub-channels in a > 10 Tb/s optical superchannel, we find that noise-corrupted
comb lines can reduce the optical signal-to-noise ratio required for the comb by
~ 9 dB when used as optical carriers at the transmitter side, and by ~ 12 dB
when used as a local oscillator at the receiver side.
ИСТОРИЯ РАЗВИТИЯ АНГЛИЙСКОГО ЯЗЫКА
Authors: Дадаева Д. М. , Хариханова Б. А.
Published: February 2021

Изучение любого языка всегда можно интерпретировать как интеллектуальное исследование. Этот интересный экскурс можно связать с тем, как менялся язык со временем и от места к месту. Сейчас мы живем в мире, где языком международного общения является английский, и сложно найти человека, который не вспомнил бы хотя бы двух – трех английских слов. Данная статья нацелена на то, чтобы проанализировать процесс формирования современного английского языка.
КОНЦЕПТ «СВОБОДА» В АНГЛИЙСКОЙ И ЧЕЧЕНСКОЙ ЛИНГВОКУЛЬТУРАХ
Authors: Докуева Х. А. , Цамакаева А. Р.
Published: February 2021

В данной статье приводится анализ основных сходств и различий концепта «свобода» (англ. «freedom», чеч. «маршо») в англоязычной и чеченской языковых картинах мира с учетом особенностей национального менталитета двух данных культур.
Научные работы, проводимые в области концептуальной сферы, доказывают, что понимание ключевых культурных лексем, в частности концепта «свобода», определяется картиной мира носителей языка, которая, в свою очередь, является результатом определенным образом зафиксированного в сознании человека представления об окружающей его действительности, и зависит это представление от культурных традиций того или иного народа.
СИНТАКСИЧЕСКИЙ ПАРАЛЛЕЛИЗМ КАК МАРКЕР СВОЕОБРАЗИЯ ИДИОСТИЛЯ ТВОРЧЕСКОЙ ЯЗЫКОВОЙ ЛИЧНОСТИ (НА МАТЕРИАЛЕ СТИХОТВОРНЫХ ПРОИЗВЕДЕНИЙ И. БАХМАН)
Authors: Толпарова Дз. В. , Дреева Дж. М.
Published: February 2021

В статье предпринимается попытка установления связи между структурно-синтаксической организацией поэтического текста и определенным типом психологической принадлежности творческой языковой личности. Предметом рассмотрения является синтаксический параллелизм, обладающий «высокой степенью развернутости» и являющийся маркером предрасположенности автора к экстравертированному типу речевого поведения. На основе анализа эмпирического материала, в качестве которого выступили стихотворные произведения И. Бахман, делается вывод о своеобразии идиостиля поэтессы и о ее психотипической принадлежности.
IMMUNOHISTOCHEMICAL FEATURES OF THE EXPRESSION OF HUMAN PAPILLOMA VIRUS TYPE 16 IN PLEOMORPHIC ADENOMAS OF SALIVARY GLAND
Authors: Brodetskyi Igor S. , Dyadyk Olena O. , Malanchuk Vladislav A. , Myroshnychenko Mykhailo S. , Krotevych Mykhailo S.
Published: February 2021

The aim is to reveal the immunohistochemical features of human papilloma virus type 16 expression in various histological variants of pleomorphic adenomas of the salivary gland.
Materials and methods: The material of the study was surgical and biopsy material from 30 patients with pleomorphic adenomas of the salivary glands, among which in 15
cases mesenchymal was detected, in 10 – mixed, in 5 cases – epithelial histological variant, respectively. Immunohistochemical study was performed, using mouse monoclonal
antibody to human papilloma virus type 16. Visualization was performed, using an EnVisionTM FLEX detection system. Histological sections of grade III cervical intraepithelial
neoplasia (CIN III) were used as a positive control; for a negative control, the procedure was performed without primary antibodies. The immunohistochemical reaction was
assessed by a semi-quantitative method by counting the percentage of positively stained cells in the field of view of a microscope × 400. Microspecimens were studied,
photoarchived on an Olympus BX-41 microscope.
Results: Expression of human papilloma virus type 16 of varying severity was determined in 26 cases of pleomorphic adenomas of the salivary glands, which was 86.7%. The
epithelial component of the pleomorphic adenoma of the salivary gland was characterized by a more pronounced expression of the monoclonal antibody to human papilloma virus
type 16 compared to the mesenchymal component of the tumor. The severity of the immunohistochemical reaction with a monoclonal antibody to human papilloma virus type
16 depended on the histological variant of the pleomorphic adenoma of the salivary gland. Epithelial, mixed and mesenchymal variants of pleomorphic adenoma of the salivary
gland were characterized, respectively, by the most pronounced, pronounced and moderately pronounced expression of a monoclonal antibody to human papilloma virus type 16.
Conclusions: A comprehensive immunohistochemical study with a monoclonal antibody to human papilloma virus type 16 revealed the presence of a causal relationship between
the infection of a patient with human papilloma virus type 16 and development of pleomorphic adenoma of the salivary gland in him.
MEDICAL STAFF IN THE CARE OF A PREGNANT PATIENT DIAGNOSED WITH FETAL DEFECT
Authors: Dawid Weronika , Maciejewska Martyna , Janik-Fuks Inga , Ćwiek Dorota , Zimny Małgorzata , Sipak-Szmigiel Olimpia
Published: February 2021

The aim: The research conducted aims at evaluating the way the medical staff functions in the care of the pregnant patient diagnosed with fetal defects.
Material and methods: 158 midwives took part in the study. The MINI-COPE standardized questionnaire and author’s questions were used.
Results: During the period when the care was provided for the pregnant patients diagnosed with fetal defects, nearly 50% of the midwives under examination complained
about the decline of their wellbeing. 75,3% of the respondents seek help and advice on how to deal with a stressful situation. Ideal for providing a systemic support, the midwives
most often chose a psychologist and a psychotherapist. The surveyed who reported no need for a systemic support for the medical staff at the workplace, as the causes of their
attitude pointed to their diminished trust in the ward nurse and no place for honest conversations. Most of the midwives surveyed during the care of the patient with the fetal
defects experienced stress and bigger mental exhaustion. Over half of the surveyed reported lack of systemic psychological support provided for the medical staff at the workplace.
Conclusions: The research indicates the need to introduce courses and training on topics related to how to deal with stressful situations into the education system of medical staff.
THE EFFECT OF DIET ENRICHED WITH PYROPHOSPHATE (E450) ON EXPRESSION OF GENES ENCODING BONE MORPHOGENETIC PROTEIN AND OSTEOCALCIN IN MOUSE EMBRYONIC MANDIBLE TISSUES
Authors: Yakubova Inessa I. , Dosenko Victor E. , Tumanovska Lesya V. , Ostrianko Volodymyr I.
Published: February 2021

The aim: Of our study was to measure the mRNA expression of the investigated odontogenesis factors in mandible tissue of mouse embryos (17th day of pregnancy) gestated by females, kept on a E450 rich diet since 30 days before fertilization to gestation.
Materials and methods: The effect of food supplements was studied in «Overload phosphates model». Experiments were carried out on white nonlinear outbred mice with mass 25−28g (n=40). The females from the control group were fed with standard rodent food, whereas the experimental females were fed with pyrophosphate-enriched food. The materials, used for the molecular genetic study, were the lower jaws of 17-days old mouse embryos (E−17).
Results: The investigated BMP2 and osteocalcin genes are expressed at approximately the same level. Pyrophosphate-rich diet does not alter BMP2 gene expression, but it significantly increases the expression of osteocalcin.
Conclusions: The present study is the first one to describe the impact of the pyrophosphate-rich diet on mRNA expression of key osteogenesis regulators – osteocalcin and BMP2.
ONE HEALTH: ANTIBIOTIC-RESISTANT BACTERIA CONTAMINATION IN FRESH VEGETABLES SOLD AT A RETAIL MARKETS IN KYIV, UKRAINE
Authors: Salmanov Aidyn G. , Ushkalov Valerii O. , Shunko Yelizaveta Ye. , Piven Natalie , Vygovska Liliia M. , Verner Olha M. , Kushnirenko Stella
Published: February 2021

The aim: To obtain the first estimates data on the occurrence of antibiotic-resistant bacteria in a wide range of fresh vegetables available in the Kyiv city markets.
Materials and methods: We performed a multicenter study. Fresh vegetables samples were collected of the six different commodity groups from eleven of retail stores locatedin Kyiv, Ukraine. Samples were tested for up to eight bacteria of concern. The susceptibility to antibiotics was determined by disk diffusion method according to the European Committee on Antimicrobial Susceptibility Testing.
Results: The antibiotic-resistant bacteria contamination in the fresh vegetables was 24.3%. The contamination among organic produce was significantly higher than in conventionally products. Contamination was found to be higher in leafy vegetables. The predominant contaminated bacteria were: Escherichia coli, Enterobacter spp. And Enterococcus faecalis, followed by Klebsiella pneumoniae, Pseudomonas aeruginosa, E. faecium, Staphylococcus aureus and Acinetobacter spp. The overall proportion of extended spectrum beta-lactamase (ESBL) production among Enterobacteriaceae was 36.8% and of methicillin-resistance in S. aureus (MRSA) 10.7%. The prevalence of ESBL production among E. coli isolates was significantly higher than in K. pneumoniae. Vancomycin resistance was observed in 3.1% of isolated enterococci (VRE). Carbapenem resistance was identified in 35.3% of P.aeruginosa isolates and 66.8% of Acinetibacter spp. isolates. Resistance to third-generation cephalosporins was observed in 9.7% K. pneumoniae and E.coli in 14.2% isolates.
Conclusions: Research has shown that the majority of fresh vegetables available in Kiev markets is contaminated with antibiotic-resistant bacteria and is a potential vehicle for the transmission of these pathogens to consumers.
ABORTION, HUMAN RIGHTS AND MEDICAL ADVANCES IN DIGITAL AGE
Authors: Razmetaeva Yulia S. , Sydorenko Olga O.
Published: February 2021

The aim: The article analyzes the impact of abortion on human rights and women’s health in the light of medical and technological advances of the digital age.
Materials and methods: The methods of research were dialectic approach and general analysis of normative and scientific sources, analysis of the results of studies of women’s mental health after abortions, analysis of judicial practice, especially decisions of the European Court of Human Rights, the results of author’s own empirical studies, the formal legal method, the comparative legal method and the historical method. It has been established that there is no strong evidence that abortion negatively affects a woman’s mental health, including no evidence that the emotional consequences aredeeply personal, or are rather the result of societal pressure. Arguments were refuted about extending the protection of human rights regarding abortion to unborn children and their fathers.
Conclusions: The article emphasizes that the ethical burden on medical workers, especially in jurisdictions that require the approval of a doctor to legally terminate a pregnancy,increases significantly due to information flows and community expectations dictated by new medical advances.
WAYS TO IMPROVE NATURAL FERTILITY
Authors: Fartushok Tetiana V. , Semenyna Halyna B. , Yurchyshyn Oksana M. , Komissarova Olha S.
Published: February 2021

The aim: Based on the study of the results of retrospective analysis, optimize ways to improve natural fertility.
Materials and methods: Data from the American Society for Reproductive Medicine and the Society for Reproductive Endocrinology and Infertility were used to study this problem.
Conclusions: With a body mass index > 35, the time reguired for conception increases by 2 times. At the same time, when the body mass index <19, the time reguired for conception increases by 4 times. Increased levels of mercury in seafood are associated with infertility. Smoking accelerates the rate of exhaustion of the ovarian follicular apparatus. When trying to become pregnant, it is advisable to avoid drinking more than 2 servings per day. Caffeine intake over 5 cups/day in women correlates with reduced fertility.
Apakah Good Corporate Governance Perspektif dan Corporate Social Responbility Indeks Berpengaruh Terhadap Kinerja Keuangan?
Authors: Putri Anandita Zulia , Pramudiati Ningrum
Published: February 2021

This study aims to determine the effect of the implementation of Good Corporate Governance perspective and Corporate Social Responsibility on financial performance in mining sector companies listed on the Indonesia Stock Exchange in 2015-2018. Good Corporate Governance consists of audit committee, the size the board of directors, the proportion of independent directors, and the number of board of commissioners. The research uses 12 samples in mining sector companies from 2015-2018 who did not have negative profit. The research sampling technique uses purposive sampling method while for data analysis uses multiple linear regression. The results show that the proxy committee variable proxy and the size of the board of directors have a significant effect on financial performance which is proxied by the ROE variable. As for the proxy variable, the proportion of independent directors and the number of board of commissioners do not significantly influence the financial performance that is proxied by ROE. Variable Corporate social responsibility index shows the results do not affect the financial performance which is proxied by the ROE variable. This research is important to be carried out as a study material for the mining industry on the importance of implementing GCG and CSR
Pengaruh Opini Audit, Pergantian Manajemen dan Pertumbuhan Perusahaan Terhadap Auditor Switching Dengan Financial Distress Sebagai Variabel Moderasi (Studi Empiris pada Perusahaan Sektor Keuangan yang Terdaftar di Bursa Efek Indonesia Tahun 2017-2019)
Authors: Kaamilah Nisa'ul , Nugroho Tatas Ridho , Dwihandoko Toto Heru
Published: February 2021

This research aims to analyze and obtain empirical evidence about the effect of audit opinion, management change and company growth on auditor switching with financial distress as a moderating variable. The population in this study were 90 financial sector companies listed on the Indonesia Stock Exchange for the 2017-2019 period. The sampling technique used purposive sampling, 42 samples were obtained for three years of observation to produce 126 units of analysis. The research data were obtained from audited financial statements, independent auditor's reports and the company's annual report downloaded from the website www.idx.co.id. The data analysis method uses descriptive statistical analysis, logistic regression analysis and Moderated Regression Analysis using SPSS version 22. The results of the study prove that simultaneous audit opinion, management change and company growth influence auditor switching. Partially the change of management and company growth has no effect on auditor switching. While audit opinion has a positive effect on auditor switching. Financial distress is able to moderate the change of management towards auditor switching, but it can’t moderate the relationship between audit opinion and company growth with auditor switching at financial sector companies listed on the Indonesia Stock Exchange in 2017-2019.
Ten ways to get a grip on designing and implementing a competency-based medical education training program
Authors: Hsu Tina , De  Angelis Flavia , Al-asaaed Sohaib , Basi Sanraj K. , Tomiak Anna , Grenier Debjani , Hammad Nazik , Henning Jan-Willem , Berry Scott , Song Xinni , Mukherjee Som D.
Published: February 2021

Background: Globally there is a move to adopt competency-based medical education (CBME) at all levels of the medical training system. Implementation of a complex intervention such as CBME represents a marked paradigm shift involving multiple stakeholders.

Methods: This article aims to share tips, based on review of the available literature and the authors’ experiences, that may help educators implementing CBME to more easily navigate this major undertaking and avoid “black ice” pitfalls that educators may encounter.

Results: Careful planning prior to, during and post implementation will help programs transition successfully to CBME. Involvement of key stakeholders, such as trainees, teaching faculty, residency training committee members, and the program administrator, prior to and throughout implementation of CBME is critical. Careful and selective choice of key design elements including Entrustable Professional Activities, assessments and appropriate use of direct observation will enhance successful uptake of CBME. Pilot testing may help engage faculty and learners and identify logistical issues that may hinder implementation. Academic advisors, use of curriculum maps, and identifying and leveraging local resources may help facilitate implementation. Planned evaluation of CBME is important to ensure choices made during the design and implementation of CBME result in the desired outcomes.

Conclusion: Although the transition to CBME is challenging, successful implementation can be facilitated by careful design and strategic planning.
Acute effect of detergent on lipid alteration in freshwater gastropod Bellamya bengalensis (Lamarck)
Authors: Kumari P. Raghava
Published: February 2021

The freshwater gastropod Bellamya bengalensis exposed to 69.18ppm concentration of detergent (Tide) on lipid content in the tissue of foot, mantle and digestive glands for 96 hours exposure. Compare to control group there was significant change in lipid contents from foot, mantle and digestive glands in detergent exposed groups. Total lipids in the digestive gland increased after 96 hrs of exposure to detergent (Tide). The percent change in lipid level is +13.87. But in case of foot and mantle, decrease of lipids was observed at 96 hrs exposure. This may be due to increased lipid synthesis or probably to facilitate transfer of materials from the storage organ to other parts of the body.
Scope and reason of travel in accordance with Maslow’s hierarchy of needs
Authors: Shrivastava Ram , Nagaich Manish
Published: February 2021

This paper examines the need and necessity of travel of people to satisfy all the levels of need which are bracketed in various five levels of hierarchy of needs namely physiological needs, safety and security needs, love and belonging need, self-esteem needs and the need of self-actualization of Maslow's.
Length-weight relationship and ponder index of two Indian major carps in Dejla Dewada reservoir, Khargone, M.P.
Authors: Pathak S.K. , Kshetre Sandhya
Published: February 2021

The total 200 specimens of Catla catla and Cirrhinus mrigla were worked out during the two year study periods, from Dejla Dewada reservoir of Khargone district. Total length and body weight were estimated. The correlation coefficient (“r”) and ponder index (“Kn”) have also been computed. The result showed the growth of two IMC is satisfactory. The value of exponent ‘n’ in the equation W=cLn were 1.9416 and 1.4798 for Catla catla and Cirrhinus mrigla. The relative condition factor (“Kn”) remained greater than one fir both IMC indicating their good well being.
Processing deteriorated beet. Part 2: Preventive and process measures
Authors: Bruijn Jan Maarten de
Published: February 2021

This paper describes the different methodologies which can be used to deal with the technological impact of deteriorated beet on processing. The procedure developed by EU sugar beet research institutes to protect long-term stored beet against the outside weather conditions is considered a necessary preventive measure to limit beet deterioration. In addition, a wide range of process measures is available to handle incoming deteriorated beet material in beet sugar manufacture. The specific dextran processing problems associated with frost-damaged beet cannot normally be solved by the usual process measures and require the addition of the rather expensive enzyme dextranase. A few alternative processes which could either improve or even enable the processing of deteriorated beet are briefly discussed. The financial consequences of processing deteriorated beet on the manufacturing costs of white sugar are outlined. Finally, the point is explained at which processing of very badly affected beet is supposed to be technologically as well as economically unacceptable.
POLİETİLENİN ALINMASI PROSESİNİN OPTİMALLAŞDIRILMASI
Authors: Əsədov Rəfail , Məhərrəmova Tamella , Məlikov Elçin
Published: February 2021

Polietilen ilk yüksək tutumlu və ən geniş yayılmış polimer materialdır. Polietilen etilenin sərbəst radikal mexanizmi ilə polimerləşməsi nəticəsində istehsal olunan sintetik polimerdir. Xüsusi plyonkalar, çantalar, plastik qablar, bidonlar istehsalı üçün ən əvəz olunmaz və vacib olan ən qədim polimerlərdən biri polietilendir. Yeni texnologiyaların sürətli inkişafına və müasir materialların tətbiqinə baxmayaraq, polietilenə tələbat daim artır. Bu nöqteyi-nəzərdən, effektiv müasir kompleks texniki vasitələrindən, effektiv riyazi modellər, metodlar və idarəetmə alqoritmlərdən istifadə edərək, yüksək təzyiqli polietilen əldə etmək üçün baxılan texnoloji prosesin optimal idarə edilməsi məsələsini həll etmək aktual və vacibdir.
Açar sözlər: yüksək təzyiqli polietilen, polimerləşmə prosesi, borulu reaktor, texnoloji parametrlər, optimallaşdırma məsələsi, termal parçalanma, Laqranj metodu, qeyri-xətti proqramlaşdırma, optimal iş rejimləri.
AKUSTİK DALĞALARIN QEYRİ XƏTTİ PARAMETRLƏRİNİN ANALİZİ
Authors: Sadəddinli Elçin
Published: February 2021

Akustik dalğaların qeyrixətlilik xassələrinin yaranmasına aid tədqiqatlar göstərir ki, elastik dalğaların yayılması prosesi həmişə qeyrixətli baş verir. Belə prosesin yaranmasının əsas səbəbi dalğaların yayılması baş verən mühitdir. Xətti asılılığın meyletmə səviyyəsinin qeyrixətti parametrlə xarakterizə olunması qəbul edilmişdir. Beləliklə, qeyrixətlilik rolunun açılması ilə akustik qeyrixətti parametrin qiyməti maddənin elastiklik xüsusiyyətlərini xarakterizə edən əlavə parametr olur.
Elastiklik xüsusiyyətləri tətbiq olunan gücün qiymətindən qeyrixətti asılıdır. Bu o deməkdir ki, akustik dalğanın bu defektlərdən keçməsi zamanı o güclü qeyrixətti təhriflərə məruz qalır. Yüksək qeyrixətti xarakteristikalara malik sahələrin lokallaşdırılması defektin yerini, hətta mümkündürsə, onun tipini də müəyyən etməyə imkan verir.
Açar sözlər: akustik dalğalar, qeyri xətti parametr, qeyrixətlilik, effekt, akustik üsul.
Penentuan Diameter Rambut Menggunakan Laser Sebagai Fenomena Difraksi Pada Biomaterial
Authors: Nuraeni Ayuni , Nurfa Nisa Nisriana , Nisa Purnama Ainun , Azzahra Ulfa Hanifa , Sujarwanto Eko
Published: February 2021

Fenomena difraksi dapat terjadi pada biomaterial misalnya terjadi pada pewarnaan bagian tubuh hewan tertentu (natural coloration). Penelitian ini bertujuan untuk menunjukkan fenomena difraksi yang melibatkan rambut sebagai biomaterial dan menentukan diameter rambut menggunakan konsep difraksi. Penelitian ini menggunakan rambut sebagai penghalang (obstacle) dan LASER merah. Hasil penelitian menunjukkan bahwa fenomena difraksi dapat dihasilkan dengan menggunakan LASER dan rambut. Sementara itu, hasil pengukuran diameter terhadap sampel rambut yaitu berkisar pada 6×10-5m sampai 18×10-5 m.  Penelitian ini menunjukkan bahwa pola difraksi dapat dibentuk dengan peralatan sederhana dan konsep difraksi dapat dimanfaatkan untuk melakukan pengukuran tak langsung.
Pengaruh Model Pembelajaran ROPES (Review, Overview, Presentation, Exercise, Summary) Terhadap Keaktifan dan Prestasi Belajar Siswa Fisika
Authors: Man Un Visensius , Hudha Muhammad Nur , Pranata Kurriawan Budi
Published: February 2021

Tujuan penelitian ini untuk mengetahui pengaruh model pembelajaran ROPES terhadap keaktifan dan prestasi belajar siswa fisika kelas VII di SMP PGRI 6 Malang dan mengetahui adanya interaksi antara model pembelajaran ROPES dengan keaktifan dan prestasi belajar siswa. Populasi dalam penelitian ini merupakan semua siswa kelas VII SMP PGRI 6 Malang. Teknik penentuan sampel menggunakan simple random sampling, di peroleh kelas VII B sebagai kelas eksperimen dan kelas VII D sebagai kelas kontrol. Metode penelitiannya merupakan Quasi Experimental Design. Rancangan penelitian pada penelitian ini mengunakan pretest - post-test control group design. Data keaktifan dikumpulkan melalui observasi dan data prestasi dikumpulkan melalui tes. Data yang terkumpul dianalisis dengan uji anova dua jalur dengan menggunakan bantuan program SPSS 16. Hasil penelitian menunjukkan adanya perbedaan keaktifan dan prestasi belajar siswa yang menggunakan pembelajaran model ROPES dengan siswa yang pembelajaran model konvensional. Hal ini diperkuat oleh nilai keaktifan dan prestasi yang lebih tinggi dengan model pembelajaran ROPES dibandingkan dengan model pembelajaran konvensional. Hasil penelitian juga menunjukkan adanya interaksi antara model ROPES terhadap keaktifan dan prestasi belajar siswa. Dengan demikian, dapat diambil simpulan bahwa model pembelajaran ROPES lebih berpengaruh terhadap keaktifan dan prestasi belajar siswa.
()-Epigallocatechin-3-Gallate Inhibits EBV Lytic Replication via Targeting LMP1-Mediated MAPK Signal Axes
Authors: Li Hongde , Li Yueshuo , Hu Jianmin , Liu Sufang , Luo Xiangjian , Tang Min , Bode Ann M. , Dong Zigang , Liu Xinqi , Liao Weihua , Cao Ya
Published: February 2021

EpsteinBarr virus (EBV)-encoded latent membrane protein 1 (LMP1) plays an important oncogenic role in the viral latent infection. Recently, increasing evidence indicates that the high expression of LMP1 during EBV lytic cycle is related to the viral lytic replication. However, the mechanism by which LMP1 regulates EBV lytic replication remains unclear. ()-Epigallocatechin-3-gallate (EGCG) prevents carcinogenesis by directly targeting numerous membrane proteins and effectively inhibits EBV lytic cascade. Here, we demonstrated that LMP1 promotes EBV lytic replication through the downstream signal molecules MAPKs, including ERKs, p38, and JNKs. LMP1 induces the phosphorylation of p53 through MAPKs to enhance the ability of wild-type p53 (wt-p53) to activate expression of BZLF1 gene, while the JNKs/c-Jun signal axis appears to be involved in EBV lytic replication induced by LMP1 in p53 mutant manner. We provided the first evidence that EGCG directly targets the viral membrane LMP1 (Kd=0.36 M,n=1) using fluorescence quenching, isothermal titration calorimetry (ITC) assay, and CNBR-activated Sepharose 4B pull-down affinity chromatography. Furthermore, we revealed that EGCG inhibits EBV lytic replication via suppressing LMP1 and thus blocking the downstream MAPKs/wt-p53 signal axis in AGS-EBV cells and JNKs/c-Jun signal axis in p53 mutant B95.8 cells. Our study, for the first time, reports the binding and inhibitory efficacy of EGCG to the LMP1, which is a key oncoprotein encoded by EBV. These findings suggest the novel function of LMP1 in the regulation of EBV lytic cycle and reveal the new role of EGCG in EBV-associated malignancies through suppressing viral reactivation.
PEMBERIAN AIR REBUSAN DAUN JAMBU BIJI TERHADAP KADAR GLUKOSA DARAH PENDERITA DIABETES MELITUS
Authors: Buheli Kartin , Ratna Ratnawati
Published: February 2021

Penelitian ini bertujuan untuk mengetahui pengaruh pemberian air rebusan daun jambu biji terhadap kadar glukosa darah pada penderita diabetes melitus di Puskesmas Kota Selatan Kota Gorontalo. Metode yang dipakai dalam penelitian ini yaitu metode Pra-Expreriment yang bersifat One group pre-test dan post-test design. Populasi dalam penelitian ini adalah semua penderita diabetes melitus di Puskesmas Kota Selatan Kota Gorontalo yang berjumlah 64 Penderita. Adapun ampel yang akan diambil oleh peneliti berjumlah 37 orang menggunakan teknik purposive sampling. Hasilnya, yaitu ada pengaruh yang sangat signifikan antara air rebusan daun jambu biji dan penurunan kadar glukosa darah pada penderita diabetes melitus di Wilayah Kerja Puskesmas Kota Selatan.
The Mechanism of Ensuring Economic Security of Strategic Interests of Machine-building Enterprises of Ukraine Taking Into Account Modern Machine-building Technologies
Authors: Ievgeniia Mishchuk , Bogdan Dergaliuk , Volodymyr Ilchenko , Irina Polishchuk , Sergii Rtyshchev
Published: February 2021

The purpose of this article is to improve the mechanism of economic security of enterprise`s strategic interests on example of machine-building enterprises of Ukraine. It is substantiated in article that existing and described in the literature mechanisms for ensuring strategic economic security have omissions. It is related with retrospective analysis of hazards (threats) and focus on resource provision. The article relations nonlinearity between level / state of economic security and results of its provision and management, provoked by influence of business environment factors beyond control of enterprise, is determined. It is proposed, in contrast to the approaches existing in the literature, to define mechanism of economic security of strategic interests as vision of dangers / threats and opportunities in future flow of events, which forms information basis for developing and implementing integrated set of management actions aimed at achieving and maintaining desired level (state) of economic security in long run. Developed mechanism is considered on example of machine-building enterprises of Ukraine. Influence of modern engineering technologies is taken into account. Analytical basis for realization of mechanism of maintenance of economic security of strategic interests of machine-building enterprises of Ukraine is developed. Its practical application will be useful for management personnel in the development and decision-making process to ensure the economic security of enterprises.
U-Slot Cut Rectangular Microstrip Antenna with a Large Ground Plane and a Thin Substrate
Authors: Garza-Resendiz Eva Karla , Reyes-Ayala Mario , Andrade-Gonzalez Edgar Alejandro , Terres-Peña Hilario
Published: February 2021

It is very well known that the Rectangular Microstrip Antennas (RMA) are narrowband, but it is possible to enhance its bandwidth by cutting slots inside the patch. Some slots variations have been used to improve this important feature in modern mobile radiocommunication systems. U-slot antennas are employed in broadband applications, but it is very important to consider the usage of a thick substrate with a low dielectric constant. In this paper, an U-slot RMA built in a The Printed Circuit Board (PCB) with a thin FR4 substrate for 800 MHz to 900 MHz is presented and analyzed. The PCB that is necessary to fabricate the antenna is very low cost and it is conformable in many mobile terminals. The antenna was simulated in HFSS and measured using return losses and its antenna patterns.
High Quality CPR Pada Alumni Keperawatan STIKES dr. Soebandi Jember
Authors: Feri Ekaprasetia  , Eky Madyaningtyas
Published: February 2021

ABSTRAK

High Quality Cardiopulmonary Resuscitation sangat dibutuhkan dalam menambah angka harapan hidup pasien dengan henti jantung. Pemantapan materi High Quality Cardiopulmonary Resuscitation di kuliah menjadi dasar pengetahuan dan ketermapilan  mahasiswa ketika sudah bekerja di tatanan klinik untuk melakukan High Quality CPR . Tujuan dari penelitian ini adalah untuk mengetahui bagaimana pengetahuan tentang High Quality Cardiopulmonary Resuscitation pada alumni keperawatan STIKES. Dr. Soebandi Jember. Desain penelitian ini adalah deskriptif analitik Sampel penelitian ini melibatkan 48 responden. Metode pengambilan sampel dengan menggunakan teknik accidental sampling selama 1 bulan. Teknik pengambilan data dengan menggunakan google form. Hasilnya adalah 100% responden pernah mengikuti pelatihan kegawatdaruratan, 77,1% responden bekerja di klinik/rumah sakit, 81,3% responden pernah melakukan CPR pada pasien dan pengetahuan responden tentang High Quality Cardiopulmonary Resuscitation masih di bawah nilai 100, yaitu rata-rata pengetahuan dengan nilai 75,83. Kesimpulan dari penelitian ini adalah pengetahuan tentang High Quality Cardiopulmonary Resuscitation perlu ditingkatkan dengan pemantapan materi pada saat tahap kuliah di program sarjana keperawatan.

Kata Kunci  : High Quality Cardiopulmonary Resuscitation, Henti Jantung, Alumni Keperawatan
Demonstrasi First Aid Pada Polisi Untuk Penanganan Korban Kecelakaan Lalu Lintas
Authors: Bayu Akbar Khayudin  , H.S Angger
Published: February 2021

ABSTRAK

Latar belakang : Prehospital care merupakan pelayanan yang dilakukan oleh perawat ambulan di luar rumah sakit pada keadaan gawat darurat baik trauma maupun non trauma. Salah satu contoh penyebab kejadian gawat darurat adalah kecelakaan lalu lintas. Penolong korban kecelakaan yang sering dijumpai dan memberikan first aid adalah petugas kepolisian. Akan tetapi keterampilan petugas kepolisian dalam memberikan pertolongan pertama pada korban kecelakaan masih dipertanyakan. Tujuan dari penelitian ini adalah untuk mengetahui keterampilan polisi dalam memberikan pertolongan pertama kecelakaan lalu lintas.

Desain pra eksperimental dengan rancangan one group pretest posttest design. sample yang diambil sebanyak 50 responden dengan Teknik non probability sampling yaitu purposive sampling.

Hasil penelitian menyatakan bahwa sebelum diberikan demonstrasi first aid menunjukkan responden yang memiliki keterampilan cukup yaitu 50 responden (100%). setelah dilakukan demonstrasi first aid sebagian besar responden setelah dilaksanakan demonstrasi memiliki keterampilan cukup yaitu 35 responden (70%) dan 15 responden (30%) memiliki keterampilan baik. Berdasarkan uji Wilcoxon signed ranks test nilai signifikansi yang diperoleh adalah Sig. 0.000.

Kesimpulannya bahwa ada pengaruh demonstrasi first aid pada polisi lalu lintas untuk penanganan korban kecelakaan lalu lintas.

Kata Kunci : Polisi, Kecelakaan, Pertolongan Pertama
Zoning of Catchments of Small Rivers in the South of the Volga Upland by the Water Protection Role of Forests
Authors:   Federal Scientific Centre of Agroecology, Complex Melioration, and Protective Afforestation, Kosheleva Olga Yu.
Published: February 2021

The article presents the results of the spatial distribution analysis of protective forest plantations within the catchment basins of in the south of the Volga Upland (within the Volgograd region). The data obtained are important for planning agroforestry and land reclamation. The interpretation of 133 reservoirs using satellite images and large-scale (Scale – 1:100 000) isolinear mapping of forest cover in the key areas allowed us to find that for the majority of catchments the low forest cover of the central part of the basin, caused by agricultural land use, is typical. The main environment protection function is performed by large forests of natural (growing in floodplains, uplands and steppe ravines) and artificial origin (forest shelterbelts), localized near the source (in watersheds) and the mouths of small rivers. Depending on the type of plantations and their presence or absence near the source or mouth of the river 6 types of forest cover of catchments in the south of the Volga Upland have been identified: I – river source and mouth have maxima (relative to the rest of the catchment basin) of natural forest cover; II – the source has a maximum of artificial forest cover, the mouth has a maximum of natural forest cover; III – there are no plantations at the source, there is a maximum of natural forest cover at the mouth; IV – there is a maximum of natural forest cover at the source, there are no plantations at the mouth; V – there is a maximum of artificial forest cover at the source, there are no plantations at the mouth; VI – there are no plantations at the source and mouth. It is found that the largest area within the south of the Volga upland is occupied by catchments of the III type (38.3 %), the relief of which is characterized by the predominance of gentle slopes, which have been exposed to the greatest extent to plowing and destruction of natural forest vegetation. Together with catchments of the IV–VI types, having no afforestation in the lower stream, about 59.2 % of plantations of the south of the Volga Upland are not protected from the processes of water erosion and deflation.
Extremely high mortality of newborn juveniles in the nursery colony of Myotis myotis at Žihobce, SW Bohemia, Czech Republic (Chiroptera: Vespertilionidae)
Authors: Červený Jaroslav , Bufka Luděk
Published: February 2021

In 2020, an extremely high mortality of juveniles was recorded in a nursery colony of Myotis myotis at Žihobce (Klatovy Dist.), reaching 50.6% of the potential growth. Most juveniles died within two weeks of age (67.4%). The cause of this phenomenon is not known. The results of chemical analyses carried out in five dead juveniles showed neither the presence of heavy metals nor pesticides in the bodies. The dissection of cadavers revealed a good nutrition state. In all dissected individuals, intestinal inflammation was recorded. Most juveniles in the colony were significantly parasitised. In the period of parturition, it was cold and very rainy for several days, the mortality thus may have been caused by chilling of the juveniles. The effort of females to nurse even the dying juveniles which fell down from the colony was observed. The mortality of juveniles was checked in further 28 control colonies in different parts of the Czech Republic in 2020. At eight sites, making up 27.6% of all studied sites, the mortality of 10.1–20.0% was recorded. At the remaining twenty sites (69% of the studied sites), the mortality reached 0–10%. High mortality of juveniles of M. myotis (18.7–39.2%) was also recorded at Vyšší Brod (Český Krumlov Dist.) in the years 1988–1991. In that case, the probable cause was the application of Lastanox (tributyltin oxide), a toxic chemical used for timber treatment in the colony roost.
Hairs of wild Felis silvestris silvestris and domestic Felis catus – are they distinctive after all? (Carnivora: Felidae)
Authors: Lehmann Lisa , Stefen Clara
Published: February 2021

This study addressed the question whether it is possible to clearly differentiate between wild and tabby domestic cats on the basis of hairs (guard hairs in particular). The colour banding pattern of individual hairs is studied in this context for the first time. Also, hair length and width, as well as parameters of the hair cuticle were checked for differences, as it is well known that wild cats have long hairs and a fine, silky fur. Several banding patterns were observed, some shared between both cat forms, but with different frequencies. But this is not enough for species differentiation and more specimens need to be studied to get a better idea of the variation in this trait. The cuticle pattern even in the same region of the hairs (medium and shield-free part of the hair shaft) varies considerably and statistically significant differences were found only for few measured parameters: hair length, hair width and scale perimeter. Nevertheless, even most of them are not sufficient to determine wild or domestic cats. However, as expected, the hairs of wild cats are statistically significantly longer than those of tabby domestic cats, and hairs longer than 50 mm can be clearly attributed to wild cats.
The systematic status of the Libyan bats of the genus Plecotus (Chiroptera: Vespertilionidae)
Authors: Spitzenberger Friederike
Published: February 2021

This paper briefly reviews the taxonomic history of the Plecotus kolombatovici complex, the bat populations which occur in isolated ranges surrounding the Mediterraean Basin, including Maghreb, Tripolitania, Cyrenaica, Anatolia, Balkans, and Italy, plus numerous Mediterranean islands. Since this complex exhibts genetic characters close to Plecotus teneriffae from the Canary Islands, the samples of the complex from Cyrenaica (NE Libya) were described as a subspecies P. teneriffae gaisleri. However, this name was later used for all populations of the complex inhabiting North Africa as P. gaisleri, a full species separated from P. kolombatovici. However, the available results of molecular genetic analyses of the complex support the opinion that these allopatric populations are conspecific and referrable to P. kolombatovici and reopens the question regarding the systematic status of P. teneriffae.
A long distance migration in Nyctalus leisleri from the Czech Republic to southern France (Chiroptera: Vespertilionidae)
Authors: Tájek Přemysl , Tájková Pavla
Published: February 2021

On 28 January 2020, three living individuals of the Leisler’s bat, Nyctalus leisleri, were found in a shed in Malaucène, southern France (44°11’34”N, 05°07’26”E). Two of these bats had bands with the inscription CESON.ORG used in the Czech Republic since 2019. The whole ring code was detected in one case (CZ03313), in a female captured and banded in a bat-box near Bečov nad Teplou, western Bohemia, Czech Republic (50°05’27”N, 12°51’38”E) on 9 September 2019, 878 km away from Malaucène. This is the first case of a long distance migration in the population of Nyctalus leisleri of the Czech Republic. This observation also gives a direct evidence of a flight during the maximum 141 days in late summer or autumn from the central or northeastern Europe to the southwestern parts of the continent.
CRIMINAL AND LEGAL CHARACTERISTICS AND PROBLEMS OF PUBLIC DANGEROUS EFFECTS OF RAPE
Authors: Акопов Эдуард Мясникович
Published: February 2021

Статья посвящена рассмотрению проблемных аспектов ст. 131 Уголовного кодекса Российской Федерации: вопросов вменения, квалификации, латентности данного деяния. Автором рассматриваются трудности квалификации данного преступления (ст. 131) от смежных статей Уголовного кодекса Российской Федерации. Для анализа субъектов данных преступлений автором выделены группы потерпевших женщин, достигших совершеннолетия, несовершеннолетних девочек и малолетних девочек, не достигших 12 лет, которые не могли осознавать совершаемых с ними действий. Также в статье рассматривается применение физического насилия для достижения состояния несопротивления от потерпевшей, которое часто приводит к причинению различного вида тяжести вреда здоровью (побои, легкий, средний, тяжелый вред здоровью), и психического насилия (угроза причинения физического насилия к иным лицам), которое влечет дополнительную квалификацию по другим статьям Уголовного кодекса Российской Федерации, а также правила их квалификации.

The article is devoted to the consideration of the problematic aspects of Art. 131 of the Criminal Code of the Russian Federation: questions of imputation, qualification, latency of this act. The author examines the difficulties of qualifying this crime (Art. 131) from related articles of the Criminal Code of the Russian Federation. For the analysis of the subjects of these crimes, the author singled out groups of women victims who have reached the age of majority, minor girls and young girls under 12 years old, who could not realize the actions committed with them. The article also discusses the use of physical violence to achieve a state of non-resistance from the victim, which often leads to infliction of various types of severity of harm to health (beatings, light, moderate, severe harm to health), and mental violence (threat of physical violence to other persons), which entails additional qualifications under other articles of the Criminal Code of the Russian Federation, as well as the rules for their qualification.
MODEL TOLERANSI PROPHETIK DI MADINAH PASCA HIJRAH DAN RELEVANSINYA TERHADAP PLURALITAS SOSIAL BUDAYA INDONESIA
Authors: Muhamad Lutfi  , Norfaridatunnisa  , Baihaki  , Mahrus Alwi Hasan Siregar
Published: February 2021

Tolerance between religious communities is an important issue to be discussed. This is because in recent years various acts of radicalism and tolerance in the name of religion have increasingly occurred in various parts of the world. This study aims to analyze the inter-religious tolerance model practiced by the Prophet Muhammad in Medina. Using a qualitative method with a literature review approach, this research found that the tolerance built by the Prophet in Medina was dominant with the positive-active tolerance model. This study also found that the reality of tolerance in Medina is basically relevant to the plurality of religions in Indonesia. Therefore, the tolerance model developed by the Prophet in Medina is relevant to be implemented in Indonesia. Of course, the implementation of the tolerance model is by adjusting the sociocultural construction of today's society.
PENGARUH FERMENTASI ALAMI LIMBAH INDUSTRI KALAMANSI TERHADAP PENINGKATAN RENDEMEN DAN MUTU MINYAK ATSIRI
Authors: Tutuarima Tuti
Published: February 2021

Orange peel oil is stored in the oil glands located on the outer skin. Orange peel contains cellulose, hemicellulose, pectin and other components. Microorganisms can damage the skin layer and are expected to increase oil yield. This study aimed to evaluate the effect of natural fermentation on citrus peel waste on yield and quality of the essential oils produced. This study used natural fermentation time as a treatment factor for 2, 3, and 4 days. The results of this study indicated that the natural fermentation time that occurs in kalamansi peel waste can increase the oil yield. Natural fermentation for 4 days produces the highest yield. This natural fermentation process also does not affect the quality characteristics of the oil.