bluuebunny/crossref_metadata_2025 huggingface dataset:
MODEL FOR PREDICTING CHANGES IN THIGH CIRCUMFERENCE CHANGES IN THE LOWER THIRD OVER TIME IN STUDENTS FROM BUKOVYNA HIGHER EDUCATIONAL INSTITUTIONS BASED ON SPORT TYPE
Authors: Karatieieva S. Yu.
Published: November 2023

The dynamic comparison of thigh circumference in the lower third was conducted in 132 students of Bukovyna (the initial study was carried out during September-October 2021, and a repeat study of these same students in September-October 2022). All students in the main group, aside from their program-specific physical activities, participated in the following sports over the year: 46 (50.00%) students played football, including 38 (41.30%) boys and 8 (8.70%) girls; 19 (20.65%) students played volleyball, including 10 (10.86%) boys and 9 (9.78%) girls; 14 (22.58%) students played handball, including 8 (8.69%) boys and 6 (6.52%) girls; 13 (14.13%) students played basketball, including 9 (9.78%) boys and 4 (4.34%) girls. Students in the control group had physical education classes according to their program requirements but did not engage in additional sports activities.

All students underwent an anthropometric assessment, specifically the measurement of thigh circumference in the lower third following the method of P.P. Shaparenka. A paired t-test was employed to compare the students' measurements between the initial assessment and a follow-up one year later. The collected data were statistically analyzed using the licensed program RStudio.

Comparing the changes in thigh circumference in the lower third between the main and control groups, it was found that students in the main group who participated in various sports had higher measurements than those in the control group, with an average difference of ±4.40 cm.

Comparing the right and left thigh circumferences in the main group demonstrated that the right thigh had a larger circumference (right: 49.26±5.60 cm, left: 45.88±5.45 cm). The comparison of thigh circumference changes over the year showed a noticeable increase in thigh girth in the middle third in 2022 compared to 2021 (right: ±1.27 cm, left: ±2.84 cm).

Hence, the predictive model for right thigh circumference (Cdr) in the lower third can be represented as follows: Cdr = β1 + β2 + 0.418w, where Cdr stands for right thigh circumference in the lower third, w denotes weight, β1 values are 25.560 for young girls and 20.165 for young boys, and β2 values are -4.497 for the control group, 0.039 for the football group, 0.039 for the handball group, and 0.502 for the volleyball group.

Similarly, the predictive model for left thigh circumference in the lower third (Cdl) is expressed as: Cdl = β1 + β2 + 0.387w, where Cdl represents left thigh circumference in the lower third, w denotes weight, β1 values are 24.638 for young girls and 18.523 for young boys, and β2 values are -0.051 for the control group, 0.379 for the football group, -0.291 for the handball group, and 0.323 for the volleyball group. Gender, sport type, and weight serve as significant predictors for predicting thigh circumference in the lower third.
ORGANIZATION OF PREVENTION, EARLY DETECTION AND TREATMENT OF GENETICALLY DETERMINED OPHTHALMOLOGICAL PROBLEMS IN AZERBAIJAN
Authors: Sultanova M.M. , Hasanova R.M. , Agayeva A.M.
Published: November 2023

The aim of this research is to present an optimized plan for organizing the prevention, early detection and treatment of genetically determined eye problems. Materials and methods. The study focuses on the process of prevention, detection and treatment of hereditary eye pathology. Specifically, it addresses issues related to the timely detection of genetically determined ophthalmic diseases leading to patient disability. The study included patients of the Acad. Zarifa Aliyeva National Centre for Ophthalmology, Baku. The study employs patient survey, analytical mapping, and statistical processing of the findings obtained. Results. Genetically determined pathology of the eye occurs quite often, this problem is most common in those countries where the percentage of consanguineous marriages is high. In some cases, hereditary pathology causes disability from early childhood. The correct approach to the problem of detecting the presence of abnormalities in early pregnancy, timely diagnosis and treatment in many cases helps to avoid the birth of children with genetic abnormalities and preserve the vision of sick patients. The organization of assistance to this category of population is multi-staged and involves various organizations not related to health care. An important role is played by the level of financial capabilities and the state of medical institutions, as well as the qualifications of the staff. The first stage of assistance to the population is to identify a risk group. At stage 2, a genetic study of the foetus is carried out in mothers included in the risk group. During stage 3, dynamic control is exercised over a newborn child from a risk group. Stage 4 is the organization of medical and surgical care for patients. The creation of a clear system of informing and helping patients with genetic abnormalities will reduce the number of visually impaired people. Conclusion. Thus, it is necessary to create a clear system of medical and preventive care for children with genetic abnormalities. Only the joint work of social services and doctors of different specialties can lead to successful results in providing care to this group of patients.
MORPHOFUNCTIONAL CHANGES OF CEREBRAL CORTEX CELLS UNDER PARTIAL TRACHEAL STENOSIS IN EXPERIMENTAL ANIMALS
Authors: Molochek Yu.A. , Savosko S.I. , Makarenko O.M.
Published: November 2023

Introduction. To date, there are limited opportunities to study the effects of congenital airway pathology in the experiment. To study the damage to body tissues in case of impaired airway ventilation, the author's version of artificial narrowing of the tracheal lumen by applying ligatures was used. The study of morphofunctional reactions and structural changes in organs and tissues of the body made it possible to identify and study pathogenetic and target tissue targets in order to develop tactics for the treatment of this pathology in newborns. Objective: to investigate the peculiarities of ultrastructural changes in the cells of the sensorimotor cortex of the cerebral hemispheres of experimental immature animals after modelling partial tracheal stenosis. Materials and methods. Ligature was applied to young rats at the level of the upper third of the trachea, which limited the tracheal lumen by about 25-30%. After modelling the pathology of the upper respiratory tract, the appearance of characteristic wheezing sounds was noted, this allowed us to consider the experimental intervention as an analogue of the stridor model in newborns. On day 7 and day 21 of the experiment, after surgery and removal of the previously applied ligature, the ultrastructure of the sensorimotor cortex of young animals was studied and, on this basis, variants of pharmacological protective and therapeutic effects and acceleration of cerebral rehabilitation in experimental animals were proposed. Results. The development of neurodystrophic processes and damage to cell ultrastructures and blood-brain barrier functions were established. After removal of the ligature from the trachea and elimination of the artificial compression effect of this factor on the airways of animals, the observed dynamics of pathological ultrastructural changes remained virtually unchanged, even after repeated surgical procedures. This indicates the need for the use of pharmacological agents and medical technologies to restore cytomembranes in cells of the central nervous system of different types under the influence of chronic hypoxia. Conclusions. Partial tracheal stenosis causes damage to the nerve cells of the cerebrocortex, and the removal of the ligature on day 7 of the stenosis modelling experiment did not affect any ultrastructural changes compared to the results obtained in the group of animals with chronic tracheal stenosis. The restoration of lung ventilation and the nature of the data revealed indicate the absence of significant recovery changes in the nerve and vascular cells of the brain. They indicate the need for urgent therapeutic and rehabilitation measures to accelerate the restoration of the structure and functions of cerebrocortical cells in the posthypoxic period.
MECHANISMS OF NITROSATIVE STRESS AND DESTRUCTION OF THE ORGANIC MATRIX OF THE RAT MANDIBLE IN THE RECOVERY PERIOD AFTER ITS INCOMPLETE FRACTURE UNDER CONDITIONS OF CHRONIC ALCOHOL INTOXICATION
Authors: Nestulia K.I. , Kostenko V.O.
Published: November 2023

The mechanisms of nitrosative stress and depolymerization of biopolymers of the mandibular bone tissue after its incomplete fracture under conditions of chronic alcohol intoxication were investigated. The experiments were conducted on 20 white Wistar rats weighing 190-240 g, divided into 4 groups: Group 1 - intact animals, Group 2 - after reproduction of chronic alcohol intoxication, Group 3 - after modeling of mandibular fracture, Group 4 - after reproduction of mandibular fracture in the setting of chronic alcohol intoxication. The activity of total NO synthase, its constitutive and inducible isoforms, ornithine decarboxylase, concentrations of peroxynitrites of alkaline and alkaline-earth metals, free hydroxyproline, N-acetylneuraminic and hexuronic acids were determined in the homogenate of the standard mandible area by spectrophotometric method. It has been shown that the reproduction of chronic alcohol intoxication significantly increases the total and inducible NO synthase activity in the mandibular homogenate, accompanied by an increase in the concentration of the key marker of nitrosative stress – peroxynitrite. On the 14th day after the reconstruction of a mandibular fracture on the background of chronic alcohol intoxication, NO synthase activity and the content of peroxynitrites of alkaline and alkaline-earth metals in the bone homogenate exceed the results of groups with separate action of pathogenic factors. Under these conditions, the activity of the key enzyme of polyamine biosynthesis, ornithine decarboxylase, significantly decreases, and the depolymerization of bone biopolymers (collagen, glycoproteins, and proteoglycans) increases, which creates prerequisites for disruption of reparative processes in the fracture site.
SUBMICROSCOPIC CHANGES OF THYMUS UNDER CELLULAR DEHYDRATION
Authors: Prykhodko O.O. , Ponyrko A.O.
Published: November 2023

Lack of water is one of the most stressful conditions for the body that can lead to changes in all the organs. The importance of the functional state of lymphoid organs for the homeostasis of the whole organism determines the relevance of their thorough investigation under their exposure to various factors, including dehydration. The purpose of the study is to investigate the patterns of submicroscopic changes in the thymus parenchyma of rats under cellular dehydration. Materials and methods. The study was conducted on 45 white mature male rats. The method of electron was applied. Results: After 10 days of the experiment, a mild level of cellular dehydration was observed, during which some cells exhibited signs of apoptosis at various stages. There were detected numerous cells in mitosis, particularly in the cortical substance of thymus lobules and the subcapsular zone. Upon reaching the 20-day mark in the experiment, an intermediate level of cellular dehydration was identified. This stage was characterized by deformations in the nuclei of both small and medium-sized thymocytes, leading to irregularities in their nuclear membrane outlines. After 30 days, under conditions of severe cellular dehydration, a reduction in the number of poorly differentiated lymphoid cells, which serve as precursors to T-lymphocytes, was observed. Thymocytes displayed unclearly defined nuclear contours and increased osmiophilicity, all vessels within the parenchyma of the gland were dilated and filled with blood, some exhibiting damage to the vessel walls, resulting in microhemorrhages, signs of stasis, and sludge syndrome within the lumen. Conclusion: The experiment has demonstrated that after 10-30 days of cellular dehydration, pronounced accidental transformation of thymus occurs, with changes intensifying over time. These findings hold relevance for morphologists and immunologists, as they may be extrapolated to other lymphoid organs under dehydration conditions. Moreover, these results lay the foundation for developing methods to prevent and treat dehydration-related conditions.
MODERN APPROACHES TO MASTERING AND IMPROVING PRACTICAL SKILLS AT THE DEPARTMENT OF HISTOLOGY, CYTOLOGY AND EMBRYOLOGY
Authors: Shepitko V.I. , Stetsuk E.V. , Boruta N.V. , Levchenko O.A. , Rud M.V.
Published: November 2023

This article outlines the organization of the educational process at the Department of Histology, Cytology, and Embryology of Poltava State Medical University. The significance of this study lies in its comprehensive approach to enhancing students' practical skills while concurrently incorporating interactive teaching methods.

Recognizing the growing importance of integrating new information technologies into education, we have introduced innovative ways for students to engage with our subject. In addition to traditional light microscopy in practical lessons, we have seamlessly integrated electronic resources and digitized histological samples into our academic curriculum.

Our department has implemented additional educational technologies through computer classes. This digital transformation of the student's learning environment enables access to a wide array of electronic educational materials, interactive testing, and digitized histological specimens. This multimedia electronic teaching resource opens up exciting avenues for progressive teaching methods, fostering increased student engagement and interest in the subject. It also allows students to study histological specimens independently, either within the Department of Histology, Cytology, and Embryology or on their personal devices, well in advance of practical classes.

Today, we can confidently assert that the process of digitizing medical education is progressing ahead of schedule. By combining traditional academic instruction with modern digital technologies and tools, we are nurturing a new generation of graduates equipped with substantial theoretical knowledge and practical skills.
AETIOLOGICAL CHARACTERISTICS OF DENTAL IMPLANT FAILURE
Authors: Yefimenko A. O. , Stepanskyi O. D. , Bogomolna L. V. , Zhernosekova I. V. , Ishchenko O. V.
Published: November 2023

Dental implant placement is a predictable and widely used procedure in modern dentistry. Nevertheless, several factors can negatively affect the functioning and duration of implant restoration. Considering the significant data supporting the role of the microbial factor in the development of tissue inflammation around the prosthesis, the purpose of this review was to investigate the etiological structure of implant loss from a microbiological point of view. Materials and methods. We conducted a comprehensive content analysis of scientific publications available in the PubMed/MEDLINE and Google Scholar databases. Results and discussion. Six groups of microorganisms are known as potential contributor to the dental biofilm. These groups are designated by a specific color – yellow, green, purple, orange and red. The orange and red groups include pathogens of periodontal inflammation, and also play a significant role in the development of peri-implant (PI) inflammation. Implants and teeth share histopathological and ecological similarities, thus, we can suggest that the microbial communities around these structures are similar. In the studies, the composition of the PI-associated complex of microorganisms including Porphyromonas gingivalis, Porphyromonas endodontalis, Tannerella forsythia, Filifactor alocis, Fretibacterium fastidiosum, Desulfobulbus spp. and Treponema lecithinolyticum was decsribed. It has been reported that the PI microbiome is specific to the site where an implant is placed, and the microbial composition of the biofilm of the contralateral healthy sites is more similar to the spectrum of healthy prostheses, including other subjects, than those from the same oral cavity. We can suggest that the changes in the implant microbiocenosis are dynamic. Several studies have shown the long-term consequences of dental implant restoration that can include the modification of the microbiome consisting in the progressive increase of P. gingivalis, T. forsythia, A. actinomycetemcomitans and Prevotella intermedia within 3-6 months following the procedure of implant placement. There is also an opinion about the peculiarities of the biofilm microbiota of the peri-implant tissues in case of early and late loss of the dental prosthesis. Bacteria are an important component of the microbiocenosis in any ecological niche, but the role of archaea is often overlooked. Methanogenic archaea, and Methanobrevibacter oralis are components of the normal oral microbiome, but their considerable prevalence may also be associated with peri-implant tissue inflammation. Conclusions. We have elucidated the complex nature of microbial communities within peri-implant sites and established an association between peri-implant diseases and the dysbiosis of subgingival microbial communities. Our study underscores the pivotal role of microbiota in peri-implant diseases.
POST-TRAUMATIC STRESS DISORDER AS PRESSING ISSUES OF OUR TIME
Authors: Mohylnyk A. , Zhyvotovska L. , Tarasenko K. , Boiko D. , Sonnik Ye. , Arkhipovets O.
Published: November 2023

The issue of combat-related psychological trauma and the development of post-traumatic disorders during wartime are of great significance now. The ongoing conflict with the invasion of neighbouring forces and the large-scale war against Ukraine poses a threat that could extend for years, if not decades, and potentially affect other regions. The constant shelling of border areas, missile attacks, and the dire social, humanitarian, and epidemiological conditions in occupied territories of Kherson, Zaporizhzhia, Donetsk and Luhansk regions have resulted in profound psychological distress among not only military personnel but also the entire population of Ukraine. This situation has led to a complex and diverse development of post-traumatic stress disorder in the contemporary context. However, despite these tragic events, this topic is of interest due to its scientific, practical, epidemiological significance, among other aspects. There is still no universally accepted theoretical framework defining approaches to the study of the psychological and biological mechanisms underlying post-traumatic stress disorder. Several pathogenetic models of the development of this disorder are currently under development. This disorder is characterized by a wide range of symptoms, including asthenia, anxiety, affective, behavioural, and psychotic disorders, which often present challenges in therapy. The most effective approach involves the use of combined pharmacological and psychotherapeutic interventions, with antidepressants being the only pharmacological agents endorsed in international clinical guidelines as first-line treatments. While experimental treatment methods exist, they require further investigation. Nonetheless, only about half of the patients achieve remission. Consequently, symptomatic therapy, placebo medications, and polypharmacy have become common in clinical practice, as clinicians attempt to address various comorbid psychopathological symptoms. This approach, to some extent, reflects the lack of well-established effective therapeutic methods and often results in prolonged illness, the development of treatment resistance, and the occurrence of side effects. In general, the efficacy of comprehensive therapy is insufficiently studied and necessitates further representative placebo-controlled and comparative clinical studies, as well as the development of more suitable and effective experimental approaches to investigate novel treatment methods.
GENETIC ASPECTS OF PROOXIDANT-ANTIOXIDANT BALANCE IN PATIENTS WITH DIABETIC NEPHROPATHY
Authors: Semenovykh P. , Nesen A. , Savicheva K. , Schenyavska O. , Shkapo V.
Published: November 2023

The aim of this work is to study the state of the prooxidative-antioxidant balance in patients with diabetic nephropathy depending on the functional state of the kidneys and taking into account the polymorphism of ACE gene. Participants and methods. This study involved 82 patients with type 2 diabetic and nephropathy. The control group consisted of 20 healthy individuals. The prooxidant-antioxidant balance of blood serum was calculated as the ratio of total hydroperoxide content to total antioxidant activity. The content of total hydroperoxides and total antioxidant activity were determined by the colorimetric method. Results. Oxidative stress plays an important role in the pathogenesis of diabetic nephropathy. Angiotensin I-converting enzyme (ACE) gene polymorphism is associated with the development and progression of acute and chronic kidney diseases. However, the features of antioxidant protection in patients with diabetic nephropathy, who are carriers of different genotypes of this polymorphism, have not been studied. Association analysis using the SNPStats online program has demonstrated that in patients with diabetic nephropathy, the I/I polymorphism is associated with an increase in the concentration of total hydroperoxides in blood serum (difference = 23.62 (6.16-41.08); p = 0.017 — codominant model inheritance; difference = 22.73 (7.70-37.75); p = 0.0042 — recessive model of inheritance). We found a significant increase of total hydroperoxides in diabetic nephropathy patients - carriers of the homozygous I/I genotype of the ACE gene polymorphism, compared to carriers of the D-allele (I/D and D/D genotypes), p=0.03.The highest values of prooxidant-antioxidant balance of blood serum in patients with diabetic nephropathy are noted in carriers of the I/I and I/D genotypes of the ACE gene/ These findings may indicate a negative effect of the I allele on the general state of the prooxidant-antioxidant balance in this category of patients. Conclusions. The analysis of the data we obtained allows us to assume an important influence of the ACE gene polymorphism on the pathogenesis of diabetic kidney disease due to changes in the prooxidant-antioxidant balance in patients with type 2 diabetes.
CLINICAL RESULTS IN PATIENTS WITH REDUCED OVARIAN RESERVE IN PROTOCOLS OF ASSISTED REPRODUCTIVE TECHNOLOGIES
Authors: Khmil S.V. , Terletska N.Yu.
Published: November 2023

Introduction. The issues of infertility treatment remain relevant, even in light of significant advances in reproductive medicine. Among the primary factors contributing to reproductive function disorders in women, age stands out prominently. The trend of women delaying pregnancy planning due to their emphasis on social fulfillment and financial stability has been steadily increasing. The aim of this study is to assess the effectiveness of protocols of controlled ovarian stimulation using pre-gravid preparation in patients with reduced ovarian reserve when using assisted reproductive technologies. Participants and methods. This study involved 112 women experiencing infertility due to reduced ovarian reserve and tubal infertility factors. These women underwent a brief ovulation stimulation protocol as part of an assisted reproductive technologies program. The participants were categorized into three groups: the first group comprised 43 women with infertility due to reduced ovarian reserve; prior to controlled ovarian stimulation (COS) and follicular puncture, this group received a combined treatment, which included a vitamin complex containing inositol ("FT500 plus"), a dietary supplement based on alpha-lipoic acid and magnesium ("Pelvidol"), dehydroepiandrosterone (DHEA), and growth hormone ("Zomacton"); the second group consisted of 38 women with infertility associated with reduced ovarian reserve who did not receive any pre-conception preparation; the third group, serving as the control, consisted of 31 women with infertility resulting from tubal factors, and they did not undergo any pre-conception preparation. The clinical outcomes of the women in both research groups and the control group were analyzed based on their treatment tactics within the ovulation stimulation protocols in assisted reproductive technologies programs. Results and discussion. The average number of oocytes obtained from patients with infertility under reduced ovarian reserve who underwent pre-gravid preparation with the medications "FT500 plus" and "Pelvidol" is statistically higher compared to the group of women with reduced ovarian reserve who did not undergo pre-gravid preparation for COS. Clinical results also indicate positive dynamics regarding proper fertilization, blastulation of embryos and subsequent pregnancy in women, who underwent pre-gravid preparation with an inositol-based pharmaceutical "FT500plus" and the dietary supplement "Pelvidol", dehydroepiandrosterone (DHEA) and "Zomacton" (growth hormone).Conclusion. The results of this clinical study demonstrate the effectiveness of pre-conception preparation for patients with reduced ovarian reserve (poor response). This preparation positively impacts the number of oocytes and embryos obtained, the controlled stimulation of oocytes, and the subsequent implantation of the embryo, leading to successful pregnancies.
ANALYSIS OF THE IMPACT OF BASE PLASTICS ON ORAL FLUID INDICATORS IN PATIENTS WEARING PARTIAL REMOVABLE DENTURES
Authors: Antoshchuk M.M.
Published: November 2023

The purpose of the study is to carry out a comparative evaluation of the analysis of the impact of partially removable dentures on the parameters of the oral fluid in individuals undergoing orthopedic rehabilitation with partial removable dentures.

Materials and Methods: To ensure the objectivity of our results, patients aged 46 to 72 years were divided into two groups: I group – control (n=22) and II group – main (n=24). Each group was further subdivided into subgroups including primary prosthetic patients and secondary prosthetic patients. The control group received partial removable constructions made from standard domestic hot polymerization plastic, while the main group underwent orthopedic treatment using advanced techniques and newly developed domestic cast plastics. To assess the interaction between acrylic plastic removable prostheses and the oral tissues during the period of patient’s adaptation to the prostheses, we conducted biophysical studies of oral fluid both before treatment and one month after wearing prosthesis.

Results: This study revealed a significant (p < 0.001) increase in pH levels in the primary control group, rising by 2.7% from (6.12±0.03) units to (6.29±0.05) units after treatment. The secondary prosthetic control group also saw a slight pH increase, from (6.16±0.04) units to (6.22±0.06) units, with no significant difference between these parameters (p > 0.05).

Conclusions: The results obtained from our improved treatment method suggest a positive impact on oral fluid parameters during the stages of treatment with partial removable lamellar prostheses. Patients in the main group experienced no significant disruptions in their oral fluid, which directly influences their adaptation to removable structures and overall quality of life.
EXPERIENCE IN APPLYING OSTEOPLASTIC MATERIALS CONTAINING MULTIPOTENT MESENCHYMAL STROMAL CELLS AND HYDROXYAPATITE IN PATIENTS BEFORE THE PROCEDURE OF DENTAL IMPLANT PLACEMENT
Authors: Bambuliak А.V. , Kuzniak N.B. , Dmytrenko R.R. , Lopushniak L.Ya.
Published: November 2023

Introduction of modern osteoplastic material into practical work is extremely important for effective filling of bone defects, restoration of lost periodontal tissue, relief of postoperative symptoms and reduction of inpatient treatment of patients after surgery. Up-to-date materials will improve regenerative and reparative properties of the bone tissue and promote its increasing volume for further successful dental implantation. Objective of the research was to determine an application effect of osteoplastic materials based on multipotent mesenchymal stromal cells of the adipose tissue and hydroxyapatite used for filling bone defects during dental surgery in patients, before dental implantation. Materials and methods. 140 patients were examined and treated by means of dental implantation. Before implantation, in order to increase the volume of the bone tissue of the cellular processes and cellular part of the corresponding jaw, various osteoplastic materials were applied during surgery. All the patients were distributed into III groups: І included 49 individuals (35,0 %), II group – 62 patients (44,29 %), and III (control) group included 29 patients (20,71 %). In I group a bone tissue substitute based on hydroxyapatite was used to restore the bone tissue of the cellular processes and the cellular pert of the corresponding jaw. In II group augmentation of bone defects was carried out by means of the suggested composition consisting of multipotent mesenchymal stromal cells of the adipose tissue, platelet-rich blood plasma and bone tissue substitute based on hydroxyapatite. In ІІІ group, the wound healed spontaneously under a blood clot. Results. After installation of dental implants, the peri-implant tissues were found to restore completely in cases where the combination of multipotent mesenchymal stromal cells of the adipose tissue, a bone substitute based on hydroxyapatite, and platelet-rich blood plasma was used for filling bone defects. Moreover, according to X-ray findings obtained 12 months later, in patients from II group the volume of the bone tissue resorption in the areas of implantation was 1,4 and 1,8 times lower than in individuals from І group, р1<0,01, and ІІІ control group, р2<0,01, respectively. Conclusions. The effectiveness of application of osteoplastic materials based on multipotent mesenchymal stromal cells of the adipose tissue and hydroxyapatite is confirmed by the values of the stability coefficient of implants. After 12 months of the research, these values were reliably higher than those of the reference, р<0,01. They were 12,43 % and 19,33 % higher than in patients from І main group and ІІІ control group.
GENERALIZED HISTOSTRUCTURAL AND MORPHOMETRIC CHARACTERISTICS OF THE FRONTAL SINUS OF HUMAN IN HEALTH
Authors: Serbin S.I. , Dubyna S.O. , Bondarenko S.V. , Sovgyrya S.M. , Koptev M.M.
Published: November 2023

The aim of our study is to determine the histo-topographic and morphometric features of the structural components of the mucous membrane of the human frontal sinus on different walls. Materials and methods: to achieve the goal, we used a set of methods for morphological studies including the method of serial semi-thin sections, histochemical studies, and the morphometric method. The thickest mucous membrane on the lower wall has an average epithelium thickness of 51.45±1.59 μm on the left and 50.78±1.64 μm on the right. On the left, the lamina propria thickness is 42.49±5.34 μm, and on the right, it is 43.03±2.22 μm. The submucosal base has a thickness of 423.67±21.33 μm on the left and 426.45±16.77 μm on the right, which is four times higher than the average thickness of the back wall and septum (p<0.05). The average diameter of the lumen of the resistive and capacitive links of the hemomicrocirculatory channel is the largest in the mucous membrane of the front wall of the human frontal sinus (respectively, 11.16±0.37 μm on the left and 11.34±0.31 μm on the right (p<0.05); 7, 63±0.08 μm on the left and 7.57±0.09 μm on the right), the smallest is in the mucous membrane of the back wall (respectively, 6.96±0.19 μm on the left and 6.56±0.35 μm on the right; 8.82±0.16 μm on the left and 9.02±0.43 μm on the right (p<0.05)). Exchangeable hemomicrovessels with the smallest diameter had a measurement of 3.89±0.08 μm on the left and 4.19±0.02 μm on the right (р<0.05) within the specified area. The study revealed the largest capillaries in the mucosal lining of the lower wall, which measured 4.88±0.07 μm on the left and 4.73±0.12 μm on the right (p<0.05). Furthermore, complex alveolar-tubular glands were evident in the submucosal base of the mucosal lining in all walls of the designated sinus. It has been found that the glands on the lower wall have the largest diameter of the terminal sections, whereas those on the septum have the smallest. On the left, the glands on the lower wall have a diameter of 30.42±2.36 μm, while those on the septum have a diameter of 25.42±1.68 μm. On the right, the corresponding measurements are 31.01±1.34 μm and 25.89±1.38 μm (p<0.05). In conclusion, this study highlights the distinct differences in gland diameter and type among different sections of the organ. The glands on the front and back comprised a mixture of protein and mucous types, while two types were identified on the lower wall and septum. The statistical processing of the obtained histo-topographic, histological, histochemical, and morphometric data significantly enhances the comprehension of the microscopic structure of the mucous membrane in the frontal sinus. These findings can be important in modern morphology and otorhinolaryngology.
On the curves lying on parallel-like surfaces of the ruled surface in $E^{3}$
Authors: YURTTANÇIKMAZ Semra
Published: November 2023

In this paper, it has been researched curves lying on parallel-like surfaces $M^{f}$ of the ruled surface $M$ in $E^{3}$. Using the definition of parallel-like surfaces it has been found parametric expressions of parallel-like surface of the ruled surface and image curve of the directrix curve of the base surface. Moreover, obtaining Darboux frames of curves lying on surfaces $M$ and $M^{f}$, it has been compared the geodesic curvatures, the normal curvatures and the geodesic torsions of these curves.
Re:Urbia : Lähiöiden segregaatiohaaste ja tulevaisuus
Authors: Vaattovaara Mari , Joutsiniemi Anssi , Bernelius Venla , Page Mathew , Rönnberg Oskar , Stjernberg Mats , Iltanen Sanna , Ramos Lobato Isabel , Jama Teemu
Published: November 2023

Re:Urbia on tutkimus lähiöiden tilasta ja kehityksestä 2020-luvun Suomessa. Hankkeessa analysoidaan lähiöiden moniulotteista segregaatioprosessia muun muassa muuttoliikkeen, koulujen ja lähiöiden veto- ja pitovoiman näkökulmasta ja konseptoidaan uudelleen lähiöiden suunnitteluratkaisuja ja palveluita. Re:Urbia on osa Ympäristöministeriön rahoittamaa lähiöohjelmaa vuosille 2020–2022.
ANALISIS KUALITAS LAPORAN KEUANGAN DAN RELEVANSINYA TERHADAP LAPORAN OPINI AUDIT PADA BADAN KEUANGAN DAN ASET DAERAH PEMERINTAH KABUPATEN ALOR
Authors: Anamuli Chindy Larasati , Wijaya I Nyoman Agus Wijaya Nyoman Agus
Published: November 2023

Penelitian ini bertujuan untuk mengidentifikasi faktor penentu meningkatkan kualitas laporan keuangan dan pengaruhnya terhadap opini audit pada Badan Keuangan dan Aset Daerah Pemerintah Kabupaten Alor. Hasil dari penelitian ini akan bermanfaat bagi pemerintah daerah untuk mengetahui bagaimana mereka dapat mencapai kualitas tinggi untuk laporan keuangan dan pada akhirnya akan mendapatkan opini Wajar Tanpa Pengecualian (WTP). Penelitian ini dilakukan berdasarkan dari fenomena pmerintah daerah (Kabupaten Alor) yang dalam 3 tahun terakhir belum mendapatkan opini WTP. Penelitian ini dilakukan dengan memproses data kualitataif dan data kuantitatif menggunakan metode campuran. Hal ini merupakan metode baru untuk mengukur kualitatif atas laporan keuangan dengan penelitian kualitatif dan pengaruhnya terhadap opini audit WTP menggunakan penelitian kuantitatif. Data diperoleh melalui wawancara dan observasi dalam Badan Keuangan dan Aset Daerah Pemerintah Kabupaten Alor. Penelitian ini menggunakan pegawai yang bekerja dalam Badan Keuangan dan Aset Daerah Pemerintah Kabupaten Alor sebagai sampel penelitian ini.

Hasil dari Penelitian ini menemukan bahwa dengan meningkatkan pengelolaan atas aset akan meningkatkan transparansi data dan akhirnya akan meningkatkan kualitas atas laporan keuangan. Dengan meningkatkan transparansi data dalam mengelola aset akan meningkatkan potensi mendapatkan opini WTP untuk laporan keuangan dalam Badan Keuangan dan Aset Daerah Pemerintah Kabupaten Alor.
PR Technologies in the Art-Cultural Realm: Interaction between PR Strategies and Vocal Artist Promotion
Authors: Lievit Dmytro
Published: November 2023

This article examines the use of PR technologies in the context of art and culture. Focusing on the Ukrainian experience, the purpose of the research is to unveil the dynamics of interaction between PR strategies and the promotion of a vocal artist. The research methodology is based on the principles of a systemic approach and content analysis, as well as fundamental tenets of the theory and history of PR technologies in the cultural and artistic sphere. Employing a research-oriented approach, a comprehensive literature review was conducted, encompassing both domestic and international sources. The research underscores the significance of effective PR tactics in the development and promotion of art projects, particularly within the Ukrainian cultural arena. The scientific novelty of this research lies in the first attempt within Ukrainian art studies to organise approaches to PR technology usage and create an algorithm within the context of vocalist promotion. Conclusions. The multifaceted role of PR technologies in shaping the image of a vocalist, their perception by the public, support, engagement, and ensuring sustained artistic influence has been revealed. It is determined that the promotion of an artist takes place on two intersecting planes: within the audience realm and the entertainment industry system. It is emphasised that among the traditional main marketing goals of the music showbiz are the maximisation of both qualitative and quantitative indicators of the artist's popularity, the enlargement of the target audience, and the enhancement of project quality. The study has identified that the social effect of the promotion process is manifested in elevating the initial social value and significance of the musical product in mass consumer consciousness, improving the performer's stage image in front of audiences, and increasing the growth of music product sales.

Keywords: PR technologies, PR strategies, vocal artist promotion, social effect.
Post-Avant-Garde and German Neo-Baroque of the 21st Century
Authors: Babukhivskyi Vasyl
Published: November 2023

The purpose of this work is to identify stylistic clarifications regarding such an all-encompassing and extremely influential direction from the last century as neo-baroque, which was perceived as an offshoot of the overall neoclassicism of the 20th century, taking into account the post-avant-garde contribution from the 1970s and the post-post-avant-garde ("neo-post-avant-garde") addition from 2010s – in the conditions of the German music world. The latter has held basic positions in art music since the times of the Viennese classicism, significantly supplying the repertoire of performance even today. The methodological basis of the study is the intonation approach, as it was noted in the works of B. Asafiev's followers in Ukraine (see the publications of D. Androsova, O. Markova, O. Muravska, and others), as well as based on the development of instrumental performance of the Odesa school (works by Z. Bupkatskyi, K. Muhlberg, other scholars). The scientific novelty of the work is noted due to the originality of the presentation of the meaning of the stylistic diffusions of instrumental art from the 20th to the 21st centuries, which made it possible to revive in the performance of works that bypassed artistry in favour of either church aestheticism of expression or frankly traditionalist thinking, which was not associated with ideas about the stylistic dynamism of German music of the last two centuries. Conclusions. The neo-baroque stylistic eclecticism of German art from the 20th century was based on the contributions of the stylistic extremism of P. Hindemith, which bypassed the "soft" detections in the works of A. Zemlinsky, Z. Wagner, F. Schmidt, and more, leading to the "neo-Schubertianism" of V. Rimm, which became the recognised leader of the German musical world at the break of the post-avant-garde and post-post-avant-garde heritages. Performance practice, performing the works of German post-avant-garde composers at the level of B. Zimmerman, J. Widman, A. Raiman, and other masters, organically combined it with the revival of the legacy of A. Zemlinsky, F. Schreker, Z. Wagner, F. Schmidt, as well as composers of the Baroque era – J. Molter, H. Telemann, and so on, whose thinking did not coincide with the criteria of the author's work of the New Age, but corresponded to the neo-baroque filling of the post-avant-garde with compositions marked by church aestheticism in bypassing the criterion of artistry, which we denote by the term "post-avant-garde neo-baroque" in music.

Keywords: baroque, neo-baroque of the 20th century, neoclassicism, post-avant-garde neo-baroque, German style in music, style of the era, post-avant-garde.
Conceptual Basis for the Development of Folklore and Jazz Direction in Cultural and Artistic Space of Ukraine in Late 20th - First Quarter of the 21st Century
Authors: Hodlevskyy Volodymyr
Published: November 2023

The purpose of the work. Based on the theoretical and practical achievements of representatives of modern folklore and jazz trends, identify and explore their conceptual basis, establish distinctive features and formulate your own vision of the development of the folklore-jazz trend in the cultural and artistic space of Ukraine in the period of late 20th – the first quarter of the 21st centuries. The research methodology consists in considering historical, analytical and systemic approaches to reveal the main principles and methods of development of the folk-jazz direction in the cultural and artistic space of Ukraine in late 20th – the first quarter of the 21st centuries. Scientific novelty lies in the actualisation and implementation of innovative developments in the spheres of theoretical, practical, and executive programme of activity in the work of the specified research direction. Conclusions. The folk-jazz direction in the cultural and artistic space of Ukraine in late 20th – the first quarter of the 21st centuries is a promising stage in the formation of musicological, cultural, and other aspects in modern Ukrainian musical art. Practical interest in mixing folklore and jazz opens up new perspectives and horizons of study, analysis, approbation and implementation of new trends, models and forms in educational, performance, and research processes. The interest and use of folk-jazz direction is really relevant in today's realities. Ukrainisation of modern music content has led to a new surge in the desire to use national melos and colour among professional musicians, actors, directors and artists and among almost all sections of society. The desire to identify each individual as a Ukrainian dictates new principles for the implementation of the folk-jazz direction in the musical culture of Ukraine and the perception of the folk code of the nation beyond its borders.

Keywords: folklore, jazz, folklore-jazz direction, musical art, art history, art, music, research, culture, culturology, innovation.
The Role Of The Opening Of The Saxophone Class In The Sixhuan Conservatory In The Establishment Of The Chinese Saxophone School
Authors: Pang Botian
Published: November 2023

The purpose of the research is to identify evidence of pedagogical, performing and scientific-methodical activities of teachers after the opening of the saxophone class at the Sichuan Conservatory in 1980. To prove that the results of their work give a reason to state the beginning of the formation of the Chinese saxophone school. Research methodology. The realisation of the purpose required the use of the following set of methods: source study – for processing and systematisation of the found materials; musicological – in the analysis of concert pedagogical, performing and scientific-methodical activities of teachers of the department of saxophone playing; systemic – in the holistic study of the activities of Chinese and Western saxophonists and the determination of their role in the formation of the saxophone school. Narrative analysis was used for specific characteristics of the performance of individual Chinese saxophonists. Scientific novelty consists in realisation of the first research of musicologist of founding and activity of pedagogical carrying out composition of class of saxophone game in Sichuan conservatory during the first twenty years of the XXI century. Conclusions. The article examines aspects of the activities of saxophone teachers of the Sichuan Conservatory and their interaction with European, American and Ukrainian specialists. The formation of a bright professional saxophone school in China has been proven.
Keywords: saxophone class, scientific-methodical and performance activities, concerts, Western saxophonists, saxophone school of China.
“Kuyavian fantasy” by V. Malyszewski in Review of Spiritual and Ethical Instructions of Polish National Revival of the First Half of the XX Century
Authors: Petrovska Natalia
Published: November 2023

The purpose of the research is to reveal the poetic and intonation uniqueness of V. Malyszewski's “Kuyavian Fantasy” in the stream of ideas of Polish national revival, actualised in the 20s and 30s of the 20th century. The methodology of the work is based on the intonation concept of music from the perspective of intonation-stylistic, etymological analysis. Analytical-musicological, genre-stylistic, and interdisciplinary approaches were essential for the work, which made it possible to reveal and investigate the genre-intonational nature of V. Malyszewski's “Kuyavian Fantasy” and its correlation with the ideas of Polish national revival at the beginning of the 20th century. The scientific novelty of the work is determined by its analytical perspective, which takes into account both the genre-stylistic specificity of V. Malyszewski's work and its correlation with the historical realities of Polish national state-building and the representation of his ideas in the culture and music of the first half of the 20th century. Conclusions. V. Malyshweski is an outstanding composer, teacher, whose multifaceted activity became a brilliant embodiment of personal Renaissance encyclopedism and creative universalism against the background of an organic synthesis of Slavic cultures, the genesis of which went back to the spiritual-national and religious-ethical guidelines of the Polish-Lithuanian Commonwealth. The latter became relevant during the period of restoration of Polish statehood (1918) against the background of the ideas of Prometheus. “Kuyavian fantasy” by V. Malyshewsky, which combined genre features of fantasy, suite and concert, became an artistic embodiment of the leading ideas of its time, symbolically directed to the ancient instructions of the Slavic world and Polish statehood, which is also evident in the programmatic appeal to the image of Kuyavia as an ancient Polish region; and to the etymological affinity of the name of these lands with ancient Kuyavia, related to ancient Ukrainian territories and Kyiv. “Kuyavian fantasy”, on the one hand, carefully reproduces the genre palette of Kuyaviak both as a regional dance-suite and as an example of Polish dance culture in general. On the other hand, the composer's overcoming of the purely applied role of this dance, which demonstrates the code section of the work, which acquires the characteristics of a majestic hymn to the revived Motherland, is indicative.

Keywords: the work of V. Malyshewski, “Kuyavian fantasy” by V. Malyshewski, the Polish-Lithuanian Commonwealth, prometheism, polonaise, kuyaviak, mazurka, Polish dance music.