bluuebunny/crossref_metadata_2025 huggingface dataset:
A novel case of glial transdifferentiation in renal medullary carcinoma brain metastasis
Authors: Gubbiotti Maria A. , McCutcheon Ian E. , Rao Priya , Genovese Giannicola , Wang Linghua , Tarasov Artem , Putintsev Vladislav , Berlinski Amber , Stupichev Danil , Kriukov Kirill , Davitavyan Suren , Salem Basim , Sarachakov Alexander , Lebedev Dmitry , Hensley Michael , Bagaev Alexander , Paradiso Francesca , Kushnarev Vladimir , Khegai Gleb , Tannir Nizar M. , Msaouel Pavlos
Published: January 2025

Renal medullary carcinoma is a rare undifferentiated tumor of the kidney associated with sickle cell trait and characterized by INI1 (SMARCB1) loss. Although metastasis to lungs, lymph nodes, and bone is commonly reported, distant spread to the central nervous system almost never occurs. Here we present an unusual case of a patient with renal medullary carcinoma with metastasis to the brain following treatment which included tazemetostat, an EZH2 inhibitor. The metastatic brain lesion harbored morphologic, immunohistochemical, and methylation profile supportive of a primary CNS phenotype with loss of the trimethylated lysine 27 residue of histone 3 while maintaining INI1 loss and a specific gene fusion shared with the patient’s tumor prior to initiation of tazemetostat therapy. Therefore, given the common genetic signatures in the brain metastasis and the patient’s prior tumor, this case represents a rare event of glial transdifferentiation in a brain metastasis of renal medullary carcinoma following the use of an epigenetic modulator. As renal medullary carcinoma has been known to cleverly utilize adaptive mechanisms for survival, we propose that such cell plasticity seen in this case may have been provoked by the use of a drug that alters the epigenetic signature of the tumor cells. Thus, careful assessment of tumor biology following novel therapeutic treatment options must be performed in order to note such unexpected consequences of treatment.
Comparison of the effect of quick response code-based training and traditional methods on the knowledge, skill, and satisfaction of the nursing students in using medical device
Authors: Bagheri-Nesami Masoumeh , Kamali Mahsa , Mollaei Amirabbas
Published: January 2025

Nurses acknowledge that their understanding of the shortcomings in the utilization of medical devices stems from insufficient knowledge about their correct usage. The use of Quick Response (QR) technology has paved a new gateway for accessing information and resources. The available evidence confirmed the usefulness of QR codes for use in clinical settings as a tool for training. The present research performed a quasi-experimental research design to compare the effect of QR code-based training and traditional methods on the knowledge, skill, and satisfaction of the nursing students in using medical device. For the control group, textual Persian manuals, visual aids in the form of pictures, and URLs were available to the students. For the intervention group, the training approach based on QR codes was explained on the first day of their presence at the heart center. The knowledge, skill and satisfaction evaluations were conducted at the end of the clinical course on day 10. The group of nursing students who used the QR code-based training method had a statistically significant higher mean knowledge and skill score compared to the traditional training method group. The level of satisfaction among students who received training using QR codes was non-significantly higher than traditional method group. Nursing managers and educators can enhance the delivery of high-quality nursing care by using QR code.
A regional site response analysis of the Petobo area after the 2018.09.28 Palu–Donggala Indonesia earthquake using an equivalent-linear model
Authors: Kusumawardani Rini , Chang Muhsiung , Upomo Togani Cahyadi , Lopez-Caballero Fernando , Permana Dadang
Published: January 2025

This paper presents a site-specific seismic ground response evaluation through convolution–deconvolution analysis in the Balaroa–Petobo area during the 2018 Palu–Donggala Indonesia earthquake. The equivalent-linear ground response analysis for the earthquake time history recorded at Balaroa was carried out using DEEPSOIL software. The results of the analysis indicate that the EW component of the earthquake motion was amplified more severely (amax) than was the NS component, as it propagated to the Petobo surface. The amplification of the bedrock motion on the Petobo surface was more serious than that on the Balaroa surface, which appears to be due to the differences in the subsurface stratification and material properties of the two sites. The Fourier spectrum and response spectra also showed greater maximum spectral accelerations (Sa,max) and maximum Fourier amplitudes (Af) at the Petobo site than at the Balaroa site. The frequency of surface soil both the Petobo and Balaroa sites computed by using comparison between response spectra analysis and the local modes analysis VS/4*H was indicated the potential decline of surface soil stiffness at Petobo area appear to account for the structural damage and liquefaction flow slides during the 2018 incident.
Clinical and radiographic outcomes of extra-short implants (≤ 6 mm) in the posterior atrophic jaws: a retrospective cohort study
Authors: Sivolella Stefano , Giovannini Stefano , Berberi Joana , Stocchero Michele , Brunello Giulia
Published: January 2025

Objective

This study aimed at investigating implant survival rate and marginal bone loss (MBL) around extra-short implants. The impact of the loading protocol and of the use of an intermediate abutment was also evaluated, to explore possible differences in terms of the outcome measures.

Materials and methods

Patients with single or multiple mandibular or maxillary posterior edentulism rehabilitated using extra-short 5–6 mm long implants were included. Different prosthetic protocols were used. Clinical and radiological follow-up was 5 years. The outcomes measures were implant survival and MBL.

Results

The analysis included 56 implants placed in 34 adults (12 males and 22 females; mean age 60 years, SD 11). Six implants failed during a median follow-up of 5 years and 4 of them were recorded in one patient at 2-year follow-up. The 5-year implant survival was 89% overall (87% in conventional and 94% in immediate loading). At univariate analysis, during follow-up immediate loading was associated with higher MBL (mean variation 0.21 mm, 95%CI 0.01 to 0.40; p = 0.02), while intermediate abutment was associated with lower MBL (mean variation -0.23 mm, 95%CI -0.39 to -0.09; p = 0.003). Multivariable analysis confirmed that immediate loading was associated with higher MBL.

Conclusion

Within its limitations, this study showed that extra-short implants under immediate loading conditions can be a reliable solution. The application of horizontal and vertical platform switching with the use of intermediate abutments seems to be able to contribute to the reduction of MBL.

Graphical Abstract
In silico analysis of hub genes and regulatory networks implicates the putamen in non-motor Parkinson’s disease disorders
Authors: Akanbi Stephen Tunmise , Yusuf Joshua Ayodele , Ayandele Thompson Oluwaferanmi , Oladipupo Dayo Samson , Olorunlowu Darasimi Racheal , Olawuyi Blessing Dorcas , Adepoju Joshua Oluwafisayo , Opasina Dolapo Emmanuel , Opoola Elizabeth Kehinde , Ugwuanyi Uchenna Victor , Adeleye Olufunto Omodele
Published: January 2025

Background

Parkinson’s disease (PD) is a neurodegenerative condition marked by the gradual degeneration of dopaminergic neurons in the substantia nigra, leading to depletion of the dopaminergic neurons in the substantia nigra as well as degeneration as and decreased activity in the putamen. This study aims to identify the role of putamen in non-motor PD symptoms as well as potential therapeutic target in the putamen of PD.

Methods

Transcriptome profiles of PD (dataset number: GSE205450, obtained from postmortem putamen and caudate samples from forty controls and thirty-five PD patients) were retrieved from the Gene Expression Omnibus (GEO) database. Specifically, we focused on putamen data for controls and PD patients. Differential gene expression analysis was carried out using with Limma, filtering for genes with |logFC|> 1 (fold change) and p < 0.05 (p-value). Protein–Protein Interaction networks were constructed using stringDB (combined score > 0.7) and analyzed in Cytoscape to identify hub genes based on various topological measures (EPC, MCC, MNC, Degree, and EcCentricity). Enrichment analysis of target genes was conducted using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). Also, we constructed transcription factor (TF)-hub gene expression networks, miRNA-hub gene expression networks, and disease hub gene association networks using the JASPAR database, Tarbase database, and DisGeNET via NetworkAnalyst platform, respectively.

Results

Seven genes, namely SST, NPY, IL6, PVALB, ALB, NTS, and TH were identified as hub genes in PD putamen. Notable miRNAs included hsa-mir-34a-5p, hsa-mir-15a-5p, hsa-mir-424-5p, and hsa-mir-19b-3p, while key transcription factors include GATA2, CREB1, FOXC1, FOXL1, TID1, NFKB1, YY1, SPIB, GATA3, and STAT3.

Conclusions

Our findings revealed close associations between the hub genes of PD putamen and non-motor symptoms of PD such as major depressive disorder, mood disorders and schizophrenia. These findings may provide a new direction for developing therapy for non-motor symptoms of PD and wet lab research is encouraged.
Serum connexin 26 as a potential marker of non-syndromic hearing loss
Authors: Moness Hend M. , Abdullah Noha M. , Amrousy Doaa El , Gamal Reham , Mohamed Hatem A. , Gomaa Mohammed A. , Hafez Shaimaa Moustafa , Mohamed Zamzam Hassan
Published: January 2025

Background

Hearing loss (HL) represents the most common form of sensory impairment in both children and adults. In children, genetic causes account for over 50%. The genetic causes of HL include multiple syndromes associated with HL. In non-syndromic hearing loss (NSHL), patients have only hearing impairment or loss. 35delG, 167delT are common mutations that lead to severe HL. The prevalence of these mutations varies according to region, population characteristics, and within the same region according to the genetic pools. There is currently no approval for laboratory investigations to diagnose non-syndromic hearing loss (NSHL) except few studies that are based on expensive genetic tests. This study evaluates the value of connexin 26 as a screening test for NSHL.

Methods

One hundred forty children participated in our study; they were divided into two groups. Seventy children with NSHL and 70 children as control group. All children were subjected to Audiometry, measurement frequency of 35delG, 167delT by PCR–RFLP, and connexin26 level by ELISA.

Results

We found that the connexin 26 level by ELISA was significantly lower in patients compared to controls (p = 0.0001). In addition, there was a significant negative correlation between connexin 26 levels and the degree of hearing loss by audiometry (r = − 0.403, p < 0.0001). In ROC curve analysis, serum levels of connexin 26 have sensitivity (94.3%) and specificity (100%). Measuring of connexin 26 by ELISA is more sensitive and specific than 35 del G mutation where sensitivity was 11.45 and 5.7% for both hetero and homo mutation.

Conclusion

Serum connexin 26 could be used as a good diagnostic marker to detect NSHL in children. It could be used as a potential marker for NSHL in newborns as it is more rapid and easily available than genetic study, especially in developing countries.
Idiopathic pulmonary fibrosis is a risk factor for cardiovascular disease: potential role of KL-6 and systemic inflammation
Authors: AbdelGhany Mohamed F. , Khaleel Waleed GamalEldin , Ahmed Asmaa Omar , Ahmed Ahmad BaheyElden , Bakkar Lamees M.
Published: January 2025

Background

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and fatal disease of the lungs. It is characterized by pulmonary and extrapulmonary comorbidities. So far, little is known as regards the prevalence of cardiovascular comorbidities in IPF patients. This study aims to investigate the prevalence of cardiovascular comorbidities in patients with IPF and correlate it with different radiological and laboratory indices of disease severity.

Methods

This prospective case–control study was performed on 134 IPF patients above 18 years. Diagnosis of IPF was based on diagnostic radiologic criteria addressed by ATS guidelines. Patients were recruited from the Pulmonology Department, Assiut University Hospitals, from June 2023 to June 2024. Cardiac comorbidities were assessed by ECG and echocardiography. All patients had C-reactive protein (CRP), Krebs von den Lungen-6 (KL-6), and lipid profile including cholesterol level, triglyceride level, HDL-cholesterol level, and LDL-cholesterol level measured. Patients were divided into two groups: IPF patients with cardiovascular comorbidities and IPF patients without cardiovascular comorbidities. Comparison between both groups as regards clinical, radiological, and laboratory criteria was carried out.

Results

The studied group consists predominantly of females (65%). Sixty out of the 134 documented IPF patients had cardiovascular comorbidities (44.7%), cardiomyopathy (mean ± SD: 43.63 ± 10.56), pulmonary hypertension (mean ± SD: 41.67 ± 15.32), ECG-ischemic changes (40.0%), and atrial fibrillation (13.3%). IPF patients with cardiovascular comorbidities vs. patients without had higher radiological HRCT total fibrosis score TFS (P value < 0.001). As regards laboratory serum biomarkers, the group with comorbidities showed significantly higher CRP, KL-6, cholesterol level, triglyceride level, and LDL-cholesterol level (P value < 0.001). Box plot analysis demonstrated significantly higher KL-6 serum level among IPF patients with cardiovascular comorbidities. Sensitivity 90.0%, specificity 94.6%, and accuracy 92.5% were associated with a cutoff value of KL-6 ≥ 299 for prediction of associated cardiovascular comorbidities among the studied IPF group.

Conclusions

Dyslipidemia and cardiovascular comorbidities were detected in a large group of IPF patients. These comorbidities were associated with a high HRCT TFS score. High serum levels of CRP and KL-6 were predictors of associated cardiovascular comorbidities in IPF.

Trial registration

ClinicalTrials.gov. NCT06539962.
Langerhans Cell Histiocytosis With Hypothalamic-pituitary and Bone Involvement: A Report of 2 Cases
Authors: Giraldi Erica A , Allen Jason W , McLemore Morgan L , Ioachimescu Adriana G
Published: January 2025

Case 1: A 31-year-old woman presented with secondary amenorrhea, polyuria, and polydipsia. Three years later, magnetic resonance imaging of the brain done for headaches found thickening of the pituitary infundibulum. Laboratory evaluation indicated central vasopressin deficiency, mild hyperprolactinemia, and central hypogonadism. Six months later, progression of the infundibular lesion was documented, now contacting the optic chiasm. Biopsy showed epithelioid histiocytes, chronic inflammation, and gliosis. On postoperative scan, a lesion in the parietal calvaria was identified, which was solitary on a bone scan. The patient received cytarabine for 12 months with resolution of infundibular and bone lesion on positron emission tomography-computed tomography scan 1 year later. Case 2: A 23-year-old man presented with polyuria, polydipsia, and unilateral tinnitus. Laboratory evaluation indicated vasopressin deficiency and central hypogonadism. External ear canal biopsy indicated an infiltrative lesion with eosinophils, small lymphocytes and histiocytes. Magnetic resonance of the brain revealed hypothalamic/infundibular and parietal and mastoid bone lesions; no other lesions were identified on positron emission tomography-computed tomography. Patient received cytarabine for 1 year with resolution of lesions, which was maintained during follow-up of 4 years. Although rare, Langerhans cell histiocytosis in adults should be considered in the appropriate clinical scenario. Multidisciplinary treatment is required.
Stellate Ganglion Blockade as Rescue Therapy for Recurrent Torsades de Pointes and as a Bridge to Surgical Sympathectomy in a Pediatric Patient: A Case Report
Authors: McWhirter Ryan , Holly Tsione , Ayad Ihab A. , Moore Jeremy P. , Biniwale Reshma , Rahman Siamak
Published: January 2025

Management of refractory ventricular fibrillation (VF) in patients with implantable implantable cardioverter defibrillator (ICD) presents a therapeutic challenge. We present a case of pediatric refractory ventricular tachycardia (VT)/Torsade de Pointe managed effectively with bilateral stellate ganglion block (SGB) with a long-acting local anesthetic for 18 days as a bridge to more definitive surgical management.
Posterior Reversible Encephalopathy Syndrome on the Operating Room Table After a Robotic Radical Nephrectomy: A Case Report
Authors: Srinivasaraghavan Nivedhyaa , Ramakrishnan Priyadarshini , Kumar K Vinoth , Balakrishnan Kalpana , Krishnamurthy Shalini Shree , Raja Anand , Kumaravel Velu Prabhakar
Published: January 2025

An elderly patient with renal cell carcinoma underwent a robotic nephrectomy. After an uneventful intraoperative period, soon after extubation she developed generalized seizures and was diagnosed with posterior reversible encephalopathy syndrome (PRES) on neuroimaging. Management included antiepileptic and antihypertensive therapies, necessitating intensive care and neurorehabilitation. This case is noteworthy as it represents the first reported instance of PRES occurring immediately in the operating room after robotic surgery. PRES was attributed to compromised renal function, chronic hypertension, and the effects of pneumoperitoneum. Early diagnosis, aggressive treatment, and rehabilitation are crucial for the management and recovery of patients with PRES.
Air–liquid interface culture combined with differentiation factors reproducing intestinal cell structure formation in vitro
Authors: Ogawa Isamu , Nakai Takaaki , Iwao Takahiro , Matsunaga Tamihide
Published: January 2025

Reproducing intestinal cells in vitro is important in pharmaceutical research and drug development. Caco-2 cells and human iPS cell-derived intestinal epithelial cells are widely used, but few evaluation systems can mimic the complex crypt-villus-like structure. We attempted to generate intestinal cells mimicking the three-dimensional structure from human iPS cells. After inducing the differentiation of iPS cells into intestinal organoids, these were dispersed into single cells and cultured two-dimensionally. An air–liquid interface culture was used, with CHIR99021, forskolin, and A-83-01 used as key compounds. Long-term culture was also performed by adding Wnt3a, Noggin, and RSPO1, which are frequently used in organoid culture. The air–liquid interface culture combined several compounds that successfully induced the formation of a crypt-villus-like structure, which grew rapidly at around day 6. The expression of pharmacokinetic genes such as CYP3A4 was also enhanced. The intestinal stem cells were efficiently maintained by the addition of Wnt3a, Noggin, and RSPO1. We were able to construct a crypt-villus-like structure on cell culture inserts, which is considered a very simple culture platform. This structure had characteristics extremely similar to living intestinal tissues and may have a superior homeostatic mechanism.
Regulation of cell cycle in plant gametes: when is the right time to divide?
Authors: Simonini Sara
Published: January 2025

Cell division is a fundamental process shared across diverse life forms, from yeast to humans and plants. Multicellular organisms reproduce through the formation of specialized types of cells, the gametes, which at maturity enter a quiescent state that can last decades. At the point of fertilization, signalling lifts the quiescent state and triggers cell cycle reactivation. Studying how the cell cycle is regulated during plant gamete development and fertilization is challenging, and decades of research have provided valuable, yet sometimes contradictory, insights. This Review summarizes the current understanding of plant cell cycle regulation, gamete development, quiescence, and fertilization-triggered reactivation.
KNTC1 introduces segmental heterogeneity to mitochondria
Authors: Tsukamura Atsushi , Ariyama Hirotaka , Hayashi Natsuki , Miyatake Satoko , Okado Satoko , Sultana Sara , Terakado Ichiro , Yamamoto Takefumi , Yamanaka Shoji , Fujii Satoshi , Hamanoue Haruka , Asano Ryoko , Mizushima Taichi , Matsumoto Naomichi , Maruo Yoshihiro , Mori Masaki
Published: January 2025

Mitochondria contribute to cellular metabolism by providing a specialised milieu for energising cells by incorporating and processing the metabolites. However, heterogeneity in the mitochondria within is only partially elucidated. Mitochondria dynamically alter their morphology and functions during the life of animals, in which cells proliferate and grow. We here show that Kntc1, a highly evolutionarily conserved protein, translocates from the Golgi apparatus to linear mitochondrial segments (LMS) upon glutamine deprivation and plays an essential role in maintaining LMS. The LMS with Kntc1 localisation exhibits an increase in the membrane potential, suggesting the role of Kntc1 in functioning as a reservoir for the energy-generating potential. Suppression of Kntc1 leads to glutamine consumption and lactate production, thus impacting cellular metabolism, eventually leading to anchorage-independent growth of cells. Indeed, the KNTC1 variant was identified in a patient with ovarian cancer, suggesting that segmental regulation of the mitochondrial function is essential for maintaining tissue integrity.
Factors influencing patient satisfaction in home care services: A systematic review
Authors: Rahadian Syah Deby Zulkarnain , Yetti Krisna , Novieastari Enie , Gayatri Dewi , Nining Sri
Published: January 2025

Background Home care services are an extension of hospital services provided by hospital staff. The hospital must conduct evaluation, coordination, and education for home care patients to ensure proper care and expedite their recovery. This service also introduces a new concept to the community, as it can help save on costs and equipment. The purpose of this study namely to determine what factors can influence patient satisfaction with home care services from previously published literature. Methods PRISMA guidelines were followed in this systematic review using three electronic databases namely ScienceDirect, Scopus, and Google Scholar. There were 228 articles with the keywords Home Care Services AND Satisfaction and derivatives of these terms, full text article type, English language. Subject nursing and health professions, with open access. The data extraction process, irrelevant articles such as articles on patient satisfaction in nursing homes and outside home care were removed. PROSPERO submitted and approved the research protocol with the following number: CRD42023482315. Result Two hundred eighty-eight articles were selected, but 10 met the inclusion criteria. It was found that factors influenced patient satisfaction with home care services. Conclusion Fifteen aspects influence patient satisfaction and two aspects that influence general patient satisfaction in long-term home care. It is expected that the results of this literature review can be used as a reference for hospitals that provide home care services to pay attention to aspects that can affect satisfaction. The author realizes that the varying methods in the articles reviewed are deficiencies in the results of this study.
A humanised thrombus-on-a-chip model utilising tissue-engineered arterial constructs: A method to reduce and replace mice used in thrombosis and haemostasis research.
Authors: Ranjbar Jacob , Gibbins Jonathan M. , Roe Jordan , Roach Paul , Yang Ying , Harper Alan G.S.
Published: January 2025

The study of in vivo thrombus formation has principally been performed using intravital microscopy in mice and other species. These have allowed us to visualise the molecular and cellular processes that regulate thrombus formation inside the body. However current in vivo arterial thrombosis models are difficult to standardise between labs and frequently produce results that do not reliably translate successfully in human clinical trials. Here we provide a step-by-step description with accompanying video tutorials to demonstrate how to produce a 3D humanised thrombus-on-a-chip model, which uses perfusion of fluorescently-labelled human blood over a mechanically-injured human tissue engineered arterial construct (TEAC) within a 3D printed microfluidic flow chamber to replicate thrombus formation within a healthy artery. We also provide a written methodology on how to use 3D printing to produce a mechanical injury press that can reproducibly damage the TEAC as a stimulus for thrombus formation as part of a mechanical injury model. Perfusion of the uninjured TEAC with whole human blood containing DiOC6-labelled platelets without initiating notable thrombus formation. The mechanical injury press was shown to induce a reproducible puncture wound in the TEAC. Fluorescence microscopy was used to demonstrate that thrombus formation could be observed reproducibly around sites of injury. This humanised thrombosis-on-a-chip model can replace the use of animals in in vivo thrombosis models for preclinical assessment of anti-thrombotic therapies. This method also offers multiple scientific advantages: allowing new drugs to be directly tested on human blood from a diverse array of donors, facilitating use of a realistic and reproducible injury modality as well as removing the potential confounding effects of general anaesthetics in animal studies. The use of human thrombus-on-a-chip models combining TEACs offers a new methodology to reduce animal use whilst improving the predictive capabilities of preclinical trials of anti-thrombotic therapies.
Enhancing Energy Efficiency in Micro-Apartments using Phase Change Materials: A Case Study in Alexandria, Egypt
Authors: Yasser Ayah , Hany Nermine , Mosaad Gihan
Published: January 2025

Background Adequate housing is a fundamental human need, yet in Egypt and the MENA region, they face challenges due to rising population pressures and economic difficulties. Affordable options are increasingly scarce, especially for those unable to meet housing market rates. This research explores micro-apartments as an eco-friendly solution aligned with global trends toward minimalism, offering compact living spaces of about 40 square meters. In Alexandria, where awareness is limited and energy consumption is high, the study emphasizes micro-apartments as a housing solution with the aim to improve thermal comfort and energy efficiency for the occupants using Phase Change Materials (PCMs) and passive design strategies. Methods This research evaluates micro-apartments as affordable housing in Egypt, emphasizing passive design and RT24HC Phase Change Material for wall insulation in Alexandria. A prototype is developed, and Design Builder software, using version 7.0.2.006 & Energy Plus 9.4 plugin, simulates the chosen RT24HC PCM’s energy efficiency. This methodology optimizes land use and enhances thermal comfort by integrating PCM with passive design, assessing Predicted Percentage of Dissatisfaction (PPD%) and Predicted Mean Vote (PMV). Results The results indicate that integrating the chosen Phase Change Material with passive design significantly lowers discomfort levels in micro-apartments. Four scenarios tested included: two layers of RT24HC PCM, one layer of RT24HC PCM with XPS insulation, two RT24HC PCM layers with window shading, and two RT24HC PCM layers with 1-meter overhang. The fourth scenario, achieving a 14.18% reduction in predicted discomfort (PPD%) and a Predicted Mean Vote of 1.3, highlights the potential of micro-apartments as an energy-efficient housing through effective PCM integration. Conclusion This study advocates for micro-apartment designs using RT24HC PCM tailored to Alexandria’s climate in Egypt to improve thermal comfort and reduce energy consumption. It provides insights for architects, developers, and policymakers in Egypt, highlighting the importance of PCM in sustainable urban housing solutions.
Atlantic mackerel population structure does not support genetically distinct spawning components
Authors: Manuzzi Alice , Aguirre-Sarabia Imanol , Díaz-Arce Natalia , Bekkevold Dorte , Jansen Teunis , Gomez-Garrido Jessica , Alioto Tyler S. , Gut Marta , Castonguay Martin , Sanchez-Maroño Sonia , Álvarez Paula , Rodriguez-Ezpeleta Naiara
Published: January 2025

Background The Atlantic mackerel, Scomber scombrus (Linnaeus, 1758) is a commercially valuable migratory pelagic fish inhabiting the northern Atlantic Ocean and the Mediterranean Sea. Given its highly migratory behaviour for feeding and spawning, several studies have been conducted to assess differentiation among spawning components to better define management units, as well as to investigate possible adaptations to comprehend and predict recent range expansion northwards. Methods Here, the genome of S. scombrus was sequenced and annotated, as an increasing number of population genetic studies have proven the relevance of reference genomes to investigate genomic markers/regions potentially linked to differences at finer scale. Such reference genome was used to map Restriction-site-associated sequencing (RAD-seq) reads for SNP discovery and genotyping in more than 500 samples distributed along the species range. The resulting genotyping tables have been used to perform connectivity and adaptation analyses. Results The assembly of the reference genome for S. scombrus resulted in a genome of 741 Mb. Our population genetic results show that the Atlantic mackerel consist of three previously known genetically isolated units (Northwest Atlantic, Northeast Atlantic, Mediterranean), and provide no evidence for genetically distinct spawning components within the Northwest or Northeast Atlantic. Conclusions Therefore, our findings resolved previous uncertainties by confirming the absence of genetically isolated spawning components in each side of the northern Atlantic, thus rejecting homing behaviour and the need to redefine management boundaries in this species. In addition, no further genetic signs of ongoing adaptation were detected in this species.
Global language geography and language history: challenges and opportunities
Authors: Urban Matthias
Published: January 2025

While it has almost become a truism of comparative linguistics that linguistic diversity is unevently distributed across the globe, the reasons are poorly understood up to the present day. Linguists are thus in the embarassing situation that they do not understand significant regularities in the way the objects of their study –languages– pattern. In this essay, I explore three interrelated strands of thought to create a perspective on the question that is different from those explored so far: first, I suggest that instead of looking at present-day levels of diversity statically, we should take an approach that looks into how these distributions were generated. Related to this point and in contradistinction to extant work, second, I advocate an inductive approach that departs from qualitative case studies that inform theory-building. Third, I ponder that, in contrast to the traditional focus of historical linguistics on language diversification and expansion, understanding how the ranges of languages are reduced might be the key missing piece of evidence in a global theory of language diversity and its genesis. This new perspective is also able to address the striking correlation between linguistic and biological diversity that suggest that the processes that created and maintain both are, on some level, qualitatively similar.
The artificial intelligence cooperative: READ-COOP, Transkribus, and the benefits of shared community infrastructure for automated text recognition
Authors: Terras Melissa , Anzinger Bettina , Gooding Paul , Mühlberger Günter , Nockels Joe , Romein C. Annemieke , Stauder Andy , Stauder Florian
Published: January 2025

Background Artificial Intelligence (AI) and Machine Learning (ML) technologies are integral to developing sophisticated digital infrastructures. Ownership and stakeholder input are critical for creating AI systems that are both innovative and accountable. This paper examines READ-COOP (https://readcoop.eu), the first platform cooperative to develop and host its own AI and ML tools (https://transkribus.org). This case study demonstrates an alternative cooperative governance model for responsible AI infrastructure. Methods We employ Research In Action and qualitative questionnaires to analyse the development of READ-COOP, following its transition from funded European Commission (EC) project to cooperative business. We assess the cooperative’s structure, management, and community engagement from 2019 to 2024. Data was collected on membership dynamics, use of Transkribus, and feedback on the cooperative’s governance and operational efficacy. Results As of October 2024, READ-COOP has 227 members from 30 countries, fostering a strong user base of over 235,000 registered individuals. Transkribus has transcribed approximately 90 million digital images of historical texts, demonstrating effective AI utilization in the cultural heritage sector, winning the European Union’s Horizon Impact Award 2020. The cooperative approach facilitates democratic decision-making, leading to sustainable growth, and significant stakeholder involvement. Qualitative feedback indicates high levels of satisfaction with the cooperative’s governance and the perceived integrity and utility of the AI infrastructure. Conclusions READ-COOP exemplifies that a cooperative business model can effectively sustain AI and ML infrastructures while promoting democratic participation and equitable ownership. This offers a viable blueprint for other sectors seeking to develop responsible and trustworthy AI solutions. We suggest that cooperative frameworks are particularly suitable for AI infrastructures initially funded through public grants, providing a sustainable transition from public development to long-term, sustainable community-ownership. We recommend wider application and exploration of cooperative models for hosting and developing AI and ML technologies to ensure their responsible creation, governance, and use.
Relationship between Blastocystis infection and clinical outcomes: A scoping review protocol
Authors: Tunali Varol , Nagavci Blin , Carmena David , Robertson Lucy J. , Doğruman Al Funda , Gentekaki Eleni , Tsaousis Anastasios D.
Published: January 2025

Blastocystis, a common protist in the human gastrointestinal tract, exhibits substantial genetic diversity and has been linked to varying clinical outcomes. However, its role in human health remains debated, with studies suggesting both commensal and pathogenic interactions. This scoping review aims to systematically map the existing evidence on the association between Blastocystis presence and human clinical outcomes. Herein, we present our proposed protocol, where, using systematic search methods, studies will be identified from multiple databases, focusing on diagnostic procedures, clinical outcomes, and treatment options. Findings will provide a comprehensive evidence map, highlighting knowledge gaps and guiding future research. The resulting data is intended to inform clinical and public health perspectives on Blastocystis and its potential implications for human health.
Behavioral Economics and Finance
Authors: Rahmeeva Irina , Komarova Oksana , Lyaskin Gennadiy , Dzhoy Elena , Zagurskiy Aleksandr , Tuhtarova Evgeniya , Filatov Dmitriy
Published: January 2025

The textbook is devoted to behavioral economics, a popular modern field of economics. Behavioral economics, as a discipline that arose at the intersection of economic theory and psychology, is of undoubted interest to both economics students and a wide audience. The main concepts that form the analytical foundation of behavioral economics are considered, as well as the areas of its application — behavioral finance, consumer behavior, choice architecture, etc.
Meets the requirements of the latest generation of federal state educational standards for higher education.
For the preparation of students of all forms of education in the fields of Economics, Management, Business Informatics, Public and Municipal Administration, researchers, business practitioners and representatives of government authorities, as well as for a wide range of readers interested in economic psychology and behavioral economics.
The latest Russian journalism
Authors: Mal'kevich Aleksandr
Published: January 2025

The textbook highlights the most important basic issues of journalism as a social institution and a modern profession. The role and functions of journalism in society, the profession of a journalist, his rights and duties, genres and genre system in journalism, types and main directions of journalism, its legal and ethical foundations in the Russian Federation are considered.
A significant place is occupied by the coverage of key issues of the creation of a journalistic work: the stages, methods of creation, compositional structure and language of the journalistic text; the use of non-verbal means, etc.
The textbook highlights such issues as social responsibility and professional values of a journalist, the implementation of the national patriotic principle of journalism, and journalistic practices during the military operation in Ukraine.
It contains self-control questions and creative tasks for each paragraph, literary sources, as well as appendices.
Meets the requirements of the latest generation of federal state educational standards for higher education.
For students majoring in Journalism and Public Relations, university professors, and anyone interested in journalism.
University lecturer: technology and organization of activities
Authors: Reznik Semen , Vdovina Ol'ga
Published: January 2025

The textbook examines the technologies and organization of the activities of a teacher of a higher educational institution. Special attention is paid to the preparation and conduct of training sessions, the use of an electronic information and educational environment in the educational process, the organization of research and educational work among students, and self-assessment of the effectiveness of a teacher's personal activities.
It is an integral part of the textbook series "Management in higher education", comprehensively covering the objects and subjects of university management: "University student", "University teacher", "Department management", "Faculty management", "Management of higher education institution".
For university teachers, as well as for heads of departments, deans and rectors of higher educational institutions.
Complexity and incoherence of self-narration versus self-esteem and perceived social support in healthy people and individuals with a diagnosis of psychotic disorders
Authors: Mazurek Martyna , Wajda Zbigniew
Published: January 2025

Cel pracy

Celem prezentowanego badania było porównanie autonarracji wśród osób z doświadczeniem psychozy i bez doświadczenia psychozy oraz korelacja tej zmiennej z samooceną i postrzeganym wsparciem społecznym w badanych grupach.

Metoda

Grupę badaną stanowiło 31 osób dorosłych z rozpoznaniem psychozy według ICD-10 (F20-29), a grupę kontrolną stanowiło 31 osób dorosłych bez rozpoznania psychiatrycznego. Bodźcem do stworzenia autonarracji uczestników była pierwsza część wywiadu autobiograficznego McAdamsa, wg którego określono spójność i złożoność wypowiedzi. Inne narzędzia wykorzystane w badaniu to kwestionariusz samooceny Rosenberga oraz skala postrzeganego wsparcia społecznego Zimeta i wsp.

Wyniki

Badania wykazały, że obie grupy różniły się istotnie pod względem złożoności autonarracji (t= -3,185; p<0,05), grupy nie różniły się istotnie pod względem spójności. Ponadto zanotowano ujemną korelację między pomiarem spójności autonarracji, a wynkiem samooceny w grupie osób zdrowych (r= -,455; p<0,05).

Wnioski

Autonarracje osób z diagnozą zaburzenia psychotycznego okazały się mniej złożone niż autonarracje osób z grupy osób zdrowych, z kolei niespójność wypowiedzi ujemnie korelowała z samooceną, lecz tylko w grupie kontrolnej. Grupy - kliniczna i kontrolna nie różniły się pod względem niespójności autonarracji. Prezentowane badanie pokazuje możliwości wykorzystania metod jakościowych i wywiadu autobiograficznego do analizy języka osób chorych psychiczne oraz zdrowych i ich powiązanie z cechami psychologicznymi. Zarówno procedura badania jak i uzyskane wyniki mają swoje ograniczenia, które szczegółowo omówiono w artykule.
Arte y ciencia. La inmolación de las células
Authors: Barrionuevo Pérez Raquel , Nogaledo Gómez Laura
Published: January 2025

La exposición "Arte y ciencia. La inmolación de las células" se llevó a cabo en el Museo Nacional de Ciencia y Tecnología (MUNCYT) en A Coruña, del 18 de julio al 30 de noviembre de 2024. Comisariada por Raquel Barrionuevo Pérez y Laura Nogaledo Gómez, la muestra reunió obras de artistas e investigadores de la Universidad de Sevilla, explorando la intersección entre arte y ciencia. Este proyecto buscó fomentar un diálogo enriquecedor entre ambas disciplinas, destacando la importancia de la investigación y la creatividad en la comprensión de fenómenos biológicos y tecnológicos contemporáneos. A través de diversas obras, se abordaron temas como la autoinmolación celular y la relación entre lo ordinario y lo extraordinario, invitando a los visitantes a reflexionar sobre la fragilidad de la vida y el impacto de la tecnología en la existencia humana. La exposición también contó con la colaboración de instituciones como la Sociedad Española de Bioquímica y Biología Molecular y la Fundación Cajasol.
Estudiantes universitarias mexicanas y la intención de emprender. Un enfoque desde la teoría de la acción planificada.
Authors: Ortiz González David Josué , Sánchez Limón Mónica Lorena
Published: January 2025

Explorar el progreso del emprendimiento desde la intención ha captado considerable
interés en diversas investigaciones. Aun así, el emprendimiento femenino no ha sido
suficientemente investigado por lo que abordar esa brecha es esencial para fomentar su
potencial. El objetivo de este trabajo es examinar un conjunto de variables psicológicas (Actitud,
Normas Subjetivas y Control Conductual) en relación con la intención de emprender entre
estudiantes universitarias mexicanas, utilizando los criterios de la teoría de la acción planificada
para la creación del modelo propuesto. Se administro un cuestionario a 303 estudiantes que se
encuentran en el nivel universitario en México. La investigación se realizó bajo un enfoque
cuantitativo, orientado a metas causales, fundamentado en un razonamiento lógico-deductivo.
El alcance de esta investigación fue de naturaleza correlacional causal, adoptando una
clasificación no experimental y de corte transversal. Los resultados obtenidos señalan una relación
positiva y significativa entre la actitud y la intención de emprender.
AGENTES E IMAGINARIOS EN LA CONSTRUCCIÓN DE LA MARCA PATRIMONIAL “ALBUFERA” (VALÈNCIA, ESPAÑA). EL CASO DE LA GASTRONOMÍA Y LA RESTAURACIÓN EN EL PARQUE NATURAL DE L’ALBUFERA.
Authors: Vizcaíno Estevan Aida
Published: January 2025

Este artículo trata de comprender la marca “Albufera” y cómo ésta dialoga con la marca,
o tal vez marcas, “Parc Natural de l’Albufera” de València. Las fronteras entre uso y
consumo patrimonial se diluyen para dar explicación al complejo entramado turísticorecreativo, presente en este humedal desde los años 30, que vive un nuevo estadio de
desarrollo con la declaración del Parque Natural. Se centra la atención en el papel que
han jugado las administraciones conservacionistas en la (re)formulación de la imagen de
la Albufera y del PNA, a través de su actuación en el proceso de declaración de nuevas
figuras patrimoniales y su interacción con los dos principales vectores turísticos del
humedal: la restauración y el paseo en barca. En el caso del sector hostelero, el denso y
complejo entramado de imaginarios superpuestos presentes en el humedal, dan espacio al vinculado con la gastronomía y su consumo patrimonial, que encuentra acomodo
conforme la figura de parque natural se consolida. En este proceso, la apropiación y
reinterpretación que las comunidades locales vinculadas al turismo y la restauración
hacen de la marca y los productos potenciados por estas oficinas, confirman la rentabilidad
económica y patrimonial que produce un espacio natural y la gastronomía que en él se
inserta.
EL LEGADO DE LOS INTELECTUALES EN LA VALORIZACIÓN Y CONOCIMIENTO DE LA CULTURA POPULAR DE ANDALUCÍA.
Authors: Herrera Justicia Sonia
Published: January 2025

Este artículo analiza la contribución de los intelectuales al conocimiento y valorización
de la cultura popular andaluza desde el siglo XIX. Artistas, escritores folcloristas y otros
estudiosos, tanto de Andalucía como de otras partes del mundo, quedaron cautivados
por sus ricas tradiciones, paisajes únicos y su universo cultural. Esta fascinación subraya
la posición preeminente de Andalucía en la historia del folclore español, marcada por
una visión romántica que destaca su diverso patrimonio cultural. El estudio se enfoca
en la labor etnográfica que permitió preservar costumbres y tradiciones andaluzas ante
los cambios sociales y la modernización. Se mencionan contribuciones significativas
de figuras como David Roberts, Demófilo, Federico García Lorca o Manuel de Falla,
quienes, a través de su arte y estudios, difundieron y revalorizaron lo popular de
Andalucía. Además, se abordan los esfuerzos por recopilar y estudiar el saber popular en Jaén y Granada, mostrando cómo este interés por lo popular se ha mantenido y
transformado hasta la actualidad, reflejando la adaptación de la cultura popular a los
cambios de su época y el resurgimiento del interés en las tradiciones en corrientes como
el “neorruralismo”
La circulación política y la distribución departamental del voto del partido Conservador entre 2006-2022
Authors: GARCIA CRUZ NICOL VANESA , TORO BONILLA LINA MARCELA
Published: January 2025

La Constitución Política de 1991 creó la circunscripción nacional del Senado en Colombia para fomentar en los candidatos la construcción de apoyos electorales en el territorio nacional. Sin embargo, los antecedentes muestran la inclinación de los candidatos por mantener sus apoyos electorales concentrados en uno o pocos departamentos aún después de 1991. Por lo cual, el presente artículo indaga si, tras los efectos de la reforma electoral de 2003, los senadores del partido Conservador han ajustado sus estrategias electorales, de acuerdo con los objetivos de los constituyentes. Para ello se implementó una metodología integrada por métodos cuantitativos que permitieron determinar la circulación política del partido, el tipo de distribución de los votos, e identificar los departamentos en los que se concentran los votos de los senadores. Finalmente, se encontró que, pasados 32 años del establecimiento de la circunscripción nacional, los senadores conservadores han concentrado sus votos en pocos departamentos entre 2006-2022.