bluuebunny/crossref_metadata_2025 huggingface dataset:
Requalificação da Orla do Rio Branco, Boa Vista - Roraima
Authors: Da Silva Morales Jefferson Eduardo , Da Silva Ferko Georgia Patricia , Guerra da Costa Graciete
Published: December 2023

As requalificações dos antigos núcleos urbanos são promulgadas pelo rótulo de promoção de melhorias para as novas utilizações dos elementos existentes, quase sempre direcionadas à indústria do turismo. Na região amazônica, alguns embriões urbanos formaram-se a partir do beira-rio e as requalificações no espaço estão sendo viabilizadas pela gestão pública sob o discurso da preservação da memória e identidade. Objetiva-se compreender o processo de requalificação da orla do Rio Branco a partir da inserção e reutilização dos elementos no espaço e atuação da gestão pública. Parte-se de abordagem crítica. Os procedimentos metodológicos caracterizaram-se pela pesquisa qualitativa exploratória com a observação participante, levantamento documental e bibliográfico. Foram evidenciadas algumas utilizações da orla do Rio Branco a partir da fundação da Fazenda Boa Vista (1830) como porta de acesso para povoamento do assentamento. Identificadas edificações como a Igreja Nossa Senhora do Carmo e Prédio da Intendência, construídas no entorno imediato da margem do rio (1830-1943). Percebe-se que durante a implantação do plano urbanístico, em 1944, o porto fluvial foi denominado pela população de Porto do Cimento, o qual teve grande importância para o desenvolvimento da cidade e região. Com o declínio do Porto, em função da adoção de outros modais, o poder público negligenciou patrimônios históricos que representavam a memória e a identidade locais. As intervenções, tal como a construção do Monumento Orla Taumanan sob a égide da requalificação do núcleo urbano e as estratégias de “modernização” da cidade, impactaram diretamente em “velhos” e “novos” problemas sociais.
APORTES LEGAIS QUE DÃO LEGITIMIDADE ÀS IMPLEMENTAÇÕES DAS RECENTES PROPOSIÇÕES CIENTÍFICAS DA BIOECONOMIA SUSTENTÁVEL.
Authors: Lopes José Carlos De Jesus , Santos Paula Silva
Published: December 2023

Neste estudo objetivou-se analisar os aportes legais brasileiros, que legitimam as implantações das recentes proposições científicas da bioeconomia sustentável, nas regiões produtoras de biomassas, no Brasil. Especificamente, discutiu-se a implementação destas recentes proposições científicas, em territórios produtivos brasileiros, que apresentam aptidões naturais ao desenvolvimento das cadeias produtivas de biomassas. As produções de biomassas, à luz dessas recentes proposições, são concebidas como modalidades de produções mais limpas de alimentos, fibras e energias alternativas, derivadas dos recursos naturais renováveis. Igualmente, são tecnicamente identificadas como uma das ações mitigadoras dos efeitos adversos das mudanças climáticas. Justifica-se este estudo, pois busca dialogar com os ramos da Ciência do Direito e com os eixos das Ciências Sociais Aplicadas, ampliando novos ambientes científicos de diálogos interdisciplinares. Para tanto, aplicou-se uma revisão bibliográfica, de caráter exploratório e descritivo, que se utilizou, exclusivamente de dados secundários, que foram tratados sob a análise de conteúdo, a partir de duas categorias. Conclui-se que os aportes legais brasileiros criam mecanismos de legitimidade às implementações das proposições científicas da bioeconomia sustentável, a fim de produzir biomassas, de forma sustentável. Assim sendo, permite o Brasil tornar um player importante nas discussões sobre a Agenda 2030, no combate à injustiça socioambiental e aos efeitos extremos das mudanças climáticas, vivenciadas por todas as pessoas que vivem no planeta, sobretudo aquelas populações consideradas como as mais vulneráveis.
Peningkatan Literasi Keuangan Masyarakat Melalui Sosialisasi Manajemen Keuangan Keluarga
Authors:   Universitas Islam Indonesia, Ahmad Hanafi Farhan , Qurtubi Qurtubi ,   Universitas Islam Indonesia, Hidayat Hasibuan Syarif ,   Universitas Islam Indonesia
Published: December 2023

The majority of the livelihoods of the people of Kenaran Hamlet are vegetable farmers and itinerant vegetable traders. In facing market realities, they are often disadvantaged by a significant decline in vegetable prices due to abundant supply. Knowledge about financial literacy and sound financial management is needed to address this wisely. To realize this, community service activities must educate the community to make their lives more economically prosperous. Departing from this, a family financial management socialization program was created to improve residents' financial literacy. This program was carried out in several stages: observation, program preparation, socialization, and evaluation. The result of this program is the local community's understanding of sound financial management and increased financial literacy to achieve economic prosperity.
Sistem Informasi Aktivitas Siswa Dalam Kegiatan Ekstrakurikuler Menggunakan Fitur Whatsapp Web
Authors:   Jurusan Sistem Informasi, Fakultas Teknik, Universitas Siliwangi, Nur Rachman Andi , Irham Gufroni Acep ,   Jurusan Sistem Informasi, Fakultas Teknik, Universitas Siliwangi, Sulastri Heni ,   Jurusan Sistem Informasi, Fakultas Teknik, Universitas Siliwangi, Nur Fitriani Dewi Euis ,   Jurusan Sistem Informasi, Fakultas Teknik, Universitas Siliwangi
Published: December 2023

Extracurricular activities in the world of education are a necessity for students to improve students' psychomotor skills. Academic activities in participating in extracurricular activities will help students form creative learning patterns and be able to increase creativity in sports and skills in areas of interest and talent. The problem that occurs at Dimitra is that there is no structure in conveying information and monitoring students when taking part in extracurricular activities at Madrasah Tsanawiyah and Madrasah Aliyah Manarul Huda. The information system implemented in this service is expected to help provide information on student development in extracurricular activities and can be monitored by parents. The method applied in this activity uses the Rapid Application Development (RAD) method and applies WhatsApp technology with the aim of much faster development with better quality. From the results of the alpha testing, it shows that the application can be applied to partners for community service within the Madrasah Tsanawiyah and Madrasah Aliyah Manarul Huda as a medium for information on extracurricular developments.
Comparative Study of Organic Fertilizers on Growth, Development and Economics of Brinjal (Solanum melongena var. Azad B-3) with Reference to Temperature.
Authors: yashvardhan vidyasagar , Singh Rambatuk , singh Devendra pratap , singh Tribhuwan
Published: December 2023

Background –The brinjal is of much importance in the warm areas of Far East, being grown extensively in India, Bangladesh, Pakistan, China and the Philippines. It is also popular in Egypt, France, Italy and United States. Preserving soil fertility throughout time by preserving organic matter and soil biological diversity, mechanical intervention, as well as exercise is highly needed in upcoming future. Effect of six different fertilizer, five organic and one synthetic fertilizers listing vermicompost, poultry manure, mustard cake, neem cake, bonemeal and N:P:K study were main concern of this investigation to find out the most suitable fertilizer for the brinjal.Result - the final growth and development through N:P:K @ 1.5%(19:19:19) outperformed all the organic fertilizers but when considering only organic fertilizer performance vermicompost@5 ton/ha was outperforming all the other organic fertilizers. Coming close to it, mustard cake@1.5ton/ha has shown its inheritance in providing nutrients. Use of other organic fertilizers are also effective use of poultry manure can provide nitrogen in higher amount in short time. Higher temperature above 25 degree Celsius cause slow growth, temperature range between 21 to 14 degrees Celsius was found better in terms of growth of flower and fruit formation.Conclusion – our experiment demonstrate specific organic fertilizer use over other fertilizers in terms of brinjal different developemental parameters and there is even comparision between synthetic fertilizer with organic fertilizer readily available in market. Vermicompost showed promising result followed by mustard cake for this specific brinjal genotype in northern plain of Indian subcontinent.
Secure Proxy Re-Encryption Protocol for FANETs Resistant to Chosen Ciphertext Attacks
Authors: Park Hyun-A
Published: December 2023

This paper proposes a Secure Proxy Re-Encryption Protocol for FANETs to address the challenges of secure transmission of medical information in off-road emergency situations. The protocol utilizes cryptographic techniques, including Proxy Re-Encryption, to protect sensitive user information and enables authorized participants to access the encrypted medical records without revealing the original encryption key. The proposed solution is designed to work with drones and smartphones, forming a secure communication network. The results of the analysis show that the proposed protocol is effective in protecting user privacy and ensuring secure transmission of medical information.
Risk Factors for the Development of Parastomal Hernia: A Retrospective Cross Section Study
Authors: Matalqah Husam , Yaseen Razan , M.Abokhsab Mahmoud , E.Matalkeh Lina , Matalkeh Mohammad , Al Taani Basil , Alswalha Husni , Al-Hajjaj Maher
Published: December 2023

Introduction:Stoma formation is among the most commonly performed surgical procedures to redirect gut contents for various reasons. Parastomal hernia (PSH) is characterized as the protrusion of abdominal contents through the abdominal wall defect in the locality of the stoma. Material and Methods:We reviewed retrospectively 65 patients with stoma formation from January2021 to January 2023. Age, smoking, hypertension, diabetes mellitus, American Society of Anesthesiologists (ASA) criteria, the etiology (benign or malignant), type of surgery, location of stoma exit, and type of stoma formed were documented.The data was collected for all patients from the hospital database. Results:We studied 65 patients. The mean age 55.96 years, with males in the majority: (70.8%).Out of 65, we had 34 patients had diabetes mellitus. Most of cases were performed trans-rectus stomas electively. The majority of cases due to malignancy.During an overall median follow-up of 12 months, 25 (38.4%) developed a parastomal hernia postoperativelyConclusion:In this study, we found an elevation in number of patients who had a parastomal hernia (PSH). Many risk factors were detected to be the main cause. One of these factors, a non-trans-rectus stoma is a risk factor for PSH. Larger studies are required.
Design and Testing of a New Type of Push-Water Aerator Device for Integrated Pond Aquaculture Systems
Authors: He Kang , Tong Chengbiao , He Lv hang , Liu Hao yu , Hu Hao yu
Published: December 2023

Over the last ten years, the integrated pond aquaculture (IPA) has been developing rapidly as a new aquaculture mode, and mechanical power oxygenator is a common oxygenation device in this aquaculture mode. However, with the gradual expansion of the application range of this aquaculture mode, the problems of low efficiency, poor oxygenation uniformity, and low applicability of mechanical power oxygenators, which can produce water reflux and suction pollution accumulation, have gradually emerged. Therefore, we designed a new type of push-water aerator device (NPWAD) applicable to the integrated recirculating water aquaculture mode of ponds. Mainly, the specific parameters of the key components were clarified through the selection calculation and structural design, and the experiments were carried out in the self-constructed pond integrated aquaculture system at the experimental base. The experiments were carried out on the water in the tank for grass carp culture, and the oxygenation and water pushing effects of the type of push-water aerator device under 15 groups of different operating parameters were carried out by using multiple types of high-precision water quality monitoring sensors, with the rotational speed of the device, the operating time (0-30 min) and the height of the water (0.5-1.5 m) as the independent variables, and the oxygenation amount R, the oxygenation power efficiency E_s and the surface layer of the water as the evaluation indexes, average flow velocity V_f were used as its evaluation indexes of oxygenation and water pushing. The results show that the optimal parameters of the NPWAD are impeller water lifting component speed n_1=1000r/min, small-hole aeration component speed n_2=2280r/min. At this time, the average oxygen increase of this device is R=1.96mg/L, the average oxygenation power efficiency is E_s=3.8 kg·(h·kW)-1, the DO uniformity of the water M_1=95.3%, and the average flow velocity V_f=190.8mm/s, which can effectively promote the water directional flow and achieve the water circulation and layer exchange, and it is in line with the preferred swimming speed of grass carp at various growth stages. The new type of push-water aerator device is able to enhance the DO concentration of the water faster, but also to achieve the purpose of promoting the directional flow of the water and renewing the water in the tank, as well as in a short period of time to improve the uniformity of the DO of the water faster, for the improvement of the pond aquaculture production efficiency has practical significance.
Role of mir-554 and mir-3117 in trigger and develop Non-small cell lung cancer
Authors: Afshinpour Maral , Ghamnak Faezeh Sojoudi , Salimi Alireza
Published: December 2023

Background: Lung cancer is known as one of the most common cancers worldwide. Non-small cell lung cancer (NSCLC) is found in 85% of cases of lung cancer. In this study, we tried to identify genes that can be used to prevent cancer from progressing by inhibiting their expression by microRNAs. These gels can be targeted as a treatment.
Method: In this study, using the data obtained from the article, 37 genes were finally reached with the Venny 2.1 database. We then analyzed the genes involved in lung cancer, using databases such as DAVID, PANTHER, and ENRICHER.
Results: Our work provides insight into PDGFRA, LAMC1, and MAP3K8 have critical roles in important pathways and biological processes which can develop cancer such as; angiogenesis, integrin signaling pathway, and development process. for the first time, mir-554 and mir-3117plays a critical role by inhibiting the proto- oncogene genes map3k8, PDGFR and lamc1.
Long non-coding RNAs underlie multiple domestication traits and leafhopper resistance
Authors: Ma Jianxin , Wang Weidong , Duan Jingbo , Wang Xutong , Feng Xingxing , Chen Liyang , Clark Chancelor , Swarm Stephen , Wang Jinbin , Lin Sen , Nelson Randall , Meyers Blake , Feng Xianzhong
Published: December 2023

The origination and functionality of long non-coding RNAs (lncRNAs) remain poorly understood. Here, we show that multiple quantitative trait loci modulating distinct domestication traits in soybeans are pleiotropic effects of a locus composed of two tandem lncRNA genes. These lncRNA genes, each containing two inverted repeats (IRs) originated from coding sequences of MYB genes, function by generating clusters of small RNAs in wild soybeans to inhibit the expression of their MYB gene relatives through posttranscriptional regulation. In contrast, the expression of the lncRNA genes in cultivated soybeans is severely repressed, and consequently, the corresponding MYB genes are highly expressed, shaping multiple distinct domestication traits as well as leafhopper resistance. The IRs were formed before the divergence of the Glycine genus from the Phaseolus/Vigna lineage and exhibit strong structure-function constraints. This study exemplifies a new type of targets for selection during plant domestication and uncovers mechanisms of lncRNA formation and action.
Quality evaluation of effective abrasive micro-edge honing based on Tra-FAH and SPA
Authors: Yu Yue , Liang Yuan , Liu Lin , Su Jie , Wang Fuwei , Zhou Jian cong , 高 阳
Published: December 2023

CNC powerful gear honing can comprehensively improve the tooth surface performance and is widely used in the finishing process of high-performance gears in the transmission system of new energy vehicles. Accurate evaluation of gear honing processing quality has important engineering application value for popularizing the process of "honing instead of grinding". In this paper, 12 factors, such as abrasive particle size, are determined qualitatively by analyzing the factors affecting gear honing accuracy, tooth surface quality and machining efficiency. Based on trapezoidal fuzzy analytic hierarchy process (Tra-FAH) and set pair analysis method (SPA), a quantitative evaluation model of CBN abrasive micro edge honing quality is established. Through the influence factor weight and key factor sensitivity analysis, it is quantitatively determined that the honing process parameters and abrasive particle size, abrasive particle shedding, abrasive particle breakage and other factors are the key factors affecting the honing quality. Taking the particle size factor as an example, the machining experiment and analysis show that the model can correctly evaluate the honing quality of high quality hardened gears and can be used to study the mechanism of honing characteristics and improve the comprehensive quality of powerful gear honing.
Effects of the Shielding Gas and Substrate Thickness on Dilution and Microstructure of Inconel® 625 MIG/MAG Welded Coatings
Authors: Macedo Rodrigo Jorge , Celente Cristiano de Azevedo , Souza Daniel , Costa Henara Lillian
Published: December 2023

Inconel® 625 alloy is a corrosion-resistant nickel-based superalloy, often deposited onto cheaper substrates due to its high cost. In this research, deposition of Inconel 625 was carried out by MIG/MAG (Metal Inert Gas/Metal Active Gas) welding process due to its ease of operation, automation and productivity. The main purpose of this work is to evaluate the shielding gas and substrate thickness on the cooling rate, dilution and microstructure of Inconel® 625 coatings welded by the MIG/MAG process. The cooling rate during deposition was measured using thermocouples. Dilution was evaluated from macrographs of cross section of the welded coatings using Image J software. The microstructure of the coatings was assessed via SEM/EDS (Scanning Electron Microscope/Energy Dispersive Spectroscopy) and X-ray diffraction (XRD). The results showed that cooling rates were higher for plates welded with Ar + 25% He, leading to lower dilution. In the microstructure, a γ-Ni matrix with precipitated phases of Mo and Nb was identified.
Data Mining of Electronic Health Records to Identify Undiagnosed Patients with Rare Genetic Diseases
Authors: Moynihan Daniel , Monaco Sean , Ting Teck Wah , Narasimhalu Kaavya , Hsieh Jenny , Kam Sylvia , Lim Jiin Ying , Lim Weng Khong , Davila Sonia , Bylstra Yasmin , Balakrishnan Iswaree Devi , Heng Mark , Chia Elian , Yeo Khung Keong , Goh Bee Keow , Gupta Ritu , Tan Tele , Baynam Gareth , Jamuar Saumya Shekhar
Published: December 2023

Rare genetic diseases affect 5-8% of the population but are often undiagnosed or misdiagnosed. Electronic health records (EHR) contain large amounts of data, which provide opportunities for analysing and mining. Data mining was performed on a database containing deidentified health records of 1.28 million patients across 3 major hospitals in Singapore, in a bid to improve the diagnostic process for patients who are living with an undiagnosed rare disease, specifically focusing on Fabry Disease and Familial Hypercholesterolaemia (FH). On a baseline of 4 patients, we identified 2 additional patients with potential diagnosis of Fabry disease, suggesting a 50% increase in diagnosis. Similarly, we identified >12,000 individuals who fulfil the clinical and laboratory criteria for FH, suggesting that data mining of EHR may allow for increased diagnosis of patients with rare disorders. This proof-of-concept study showed that it is indeed possible to perform data mining on EHR albeit with some challenges and limitations.
VIRMA-mediated m6A modification is essential for active ribosome biogenesis
Authors: Zhou Tao , Wu Min , Wu Xiaoli , Sun Haifeng , Wang Wen , Zhang Leyi , Liu Xia , Zhang Yifan , Zhang Xinning , Liu Jun , Shen Bin
Published: December 2023

N6-methyladenosine (m6A) modification plays crucial roles in tissue development and homeostasis. However, the mechanisms underlying cellular adaptation of m6A modification and their impact on protein synthesis machinery remain unclear. VIRMA, the largest and evolutionarily conserved core of the m6A methyltransferase complex, is highly expressed in the embryonic brain and various cancers. Here, we demonstrate that VIRMA-mediated m6A modification is essential for active ribosome biogenesis. VIRMA depletion destabilizes the entire writer complex and reduces m6A levels, leading to decreased proliferation and increased apoptosis of neural progenitor/stem cells (NPCs), ultimately causing severe forebrain developmental defects. Mechanistically, VIRMA depletion impairs ribosome biogenesis by inhibiting mRNA decay, triggering a P53-dependent ribosomal stress response and compromising global protein synthesis. Importantly, these findings extend to human cancer cells, suggesting the conservation of this mechanism. Overall, our study reveals the critical role of m6A in adapting protein synthesis machinery during brain development and in cancer.
Repeat drug-coated balloon angioplasty for femoropopliteal lesions: 12-month results from a retrospective observational study
Authors: Haraguchi Takuya , Tsujimoto Masanaga , Kashima Yoshifumi , Sato Katsuhiko , Fujita Tsutomu
Published: December 2023

Background: The clinical implications of restenosis after drug-coated balloon (DCB) treatment remain unclear. We compared the clinical outcomes between DCB angioplasty for restenosis and de novo femoropopliteal artery lesions. This single-center retrospective study included 571 patients (737 limbs) who underwent either repeat (54 patients, 64 limbs) or de novo DCB (517 patients, 673 limbs) without bailout stenting. After propensity score matching, 49 matched pairs were analyzed. The primary endpoint was the 1-year primary patency, with secondary endpoints including the freedom from target lesion revascularization (TLR), major adverse limb events (MALE), and early restenosis.
Results: The repeat-DCB group displayed significantly lower rates of 1-year primary patency and freedom from TLR compared to those of the de novo-DCB group (50.1% vs. 77.4%, p=0.029 and 54.9% vs. 83.6%, p=0.0.44, respectively). No significant differences were observed in early restenosis or MALE (10.7% vs. 5.9%, p=0.455 and 48.3% vs. 73.4%, p=0.055, respectively). Restenosis after DCB angioplasty was associated with repeat DCB (hazard ratio [HR], 5.13; 95% confidence interval [CI], 1.43–18.4; p=0.012) and small vessel size of <4.5 mm (HR, 6.25; 95% CI, 1.17–33.4; p=0.032). Furthermore, restenosis after repeat DCB angioplasty was associated with the Peripheral Artery Calcification Scoring System (PACSS) grade 4 (HR, 4.20; 95% CI, 1.08–16.3; p=0.038), small vessel size of <4.5 mm (HR, 9.44; 95% CI, 1.21–73.7; p=0.032), and intravascular ultrasound (IVUS) use (HR, 0.05; 95% CI, 0.01–0.44; p=0.007).
Conclusions: The 1-year primary patency rate following repeat DCB angioplasty for femoropopliteal lesions was notably lower than that of DCB treatment for de novo lesions. Repeat DCB strategy was associated with an increased risk of patency loss. Regarding repeat restenosis after DCB treatments, PACSS grade 4 calcification and small vessel diameter of <4.5 mm were associated with an increased risk of restenosis, whereas IVUS use correlated with a decreased risk of restenosis.
Co-option and neofunctionalization of stomatal executors for defense against herbivores in Brassicales
Authors: Shirakawa Makoto , Oguro Tomoki , Sugano Shigeo , Yamaoka Shohei , Sagara Mayu , Tanida Mai , Sunuma Kyoko , Iwami Takuya , Nakanishi Tatsuyoshi , Horiuchi Keita , Kumaishi Kie , Yoshida Soma , Watanabe Mutsumi , Tohge Takayuki , Suzuki Takamasa , Ichihashi Yasunori , Takemiya Atsushi , Yamaguchi Nobutoshi , Kohchi Takayuki , Ito Toshiro
Published: December 2023

Co-option of gene regulatory networks leads to the acquisition of new cell types and tissues. Stomata, valves formed by guard cells (GCs), are present in most land plants and regulate CO2 exchange. The transcription factor (TF) FAMA globally regulates GC differentiation but also promotes the development of idioblast myrosin cells (MCs), another type of specialized cell along the vasculature essential for Brassicales-specific chemical defenses. Here, we show that the TF gene WASABI MAKER (WSB), directly induced by FAMA, triggers MC differentiation. WSB and STOMATAL CARPENTER 1 (SCAP1), a stomatal lineage–specific direct FAMA target, synergistically promote GC differentiation. wsb mutants lacked MCs, while the wsb scap1 double mutant lacked normal GCs. Evolutionary analyses revealed that WSB is conserved across stomatous angiosperms. Furthermore, the FAMA–WSB positive feedback loop acts as a cell fate switch. We propose that the conserved and reduced transcriptional FAMA–WSB module was co-opted before evolving to induce MC differentiation.
Proteome profiling of serum reveals PSMD6 as a biomarker in breast cancer metastasis
Authors: Ding Chen , Meng Yue , Huang Minjing , Xu Ganfei , Li Xinwei , Gu Bing
Published: December 2023

Breast cancer (BC) has the highest mortality rate and prevalence among cancers in females worldwide. Here, we performed proteomic profiling of 322 serum samples from the discovery cohort [56 healthy controls (HCs), 112 benign breast tumor (BBT) patients, and 154 BC patients] and a prospective validation cohort [27 HCs, 29 BBT patients and 57 BC patients]. Integrated proteomic analysis of tissue and serum samples revealed highly specific tumor biomarkers and demonstrated that the serum proteome can distinguish the different pathological substages in BC progression. We also identified PSMD6 as a potential metastatic breast cancer (MBC) biomarker. Comprehensive analysis of the multicenter independent validation cohort, which included retrospective and prospective cohorts including 61 HCs, 72 BBT patients, and 247 BC patients, indicated that PSMD6 overexpression was an important cause of BC metastasis and an indicator of poor prognosis. Further study revealed that the CLTA-PSMD6-neutrophil axis promotes the transition from invasive ductal carcinoma (IDC) to MBC. Importantly, CLTA amplification might be a potential therapeutic target for MBC patients. We also developed a highly accurate predictive model (accuracy = 0.87) to differentiate benign and malignant tumors and validated its good performance in the prospective validation cohort. Collectively, this study demonstrates the elaborate BC serum proteomic landscape and provides valuable information regarding serum biomarkers, which could reveal novel therapeutic targets and provide opportunities for MBC treatment.
Corporate lobbying and its implications for global food governance: mapping and analysing the global corporate influence network of the transnational ultra-processed food industry
Authors: Slater Scott , Lawrence Mark , Wood Benjamin , Serodio Paulo , Baker Phillip
Published: December 2023

Background
A major challenge to transforming food systems to promote human health and sustainable development is the global rise in the manufacture and consumption of ultra-processed foods (UPFs). A key driver of this dietary transition is the globalization of UPF corporations, and their organized corporate political activity (CPA) intended to counter opposition and block government regulation. UPF industry CPA and the corporate interest groups who lobby on their behalf have been well described at the national level, however, at the global level, this network has not been systematically characterized. This study aims to map, analyse, and describe this network, and discuss the implications for global food policy action on UPFs, global food governance (GFG), and food systems transformation.
Methods
We conducted a network analysis of the declared interest group memberships of the world's leading UPF corporations, extracted from web sources, company reports, and relevant academic and grey literature. Data on the characteristics of these interest groups were further extracted for analysis, including year founded, level, type, and headquarter location.
Results
We identified 268 interest groups affiliated with the UPF industry. The UPF manufacturers Nestlé (n = 171), The Coca-Cola Company (n = 147), Unilever (n = 142), PepsiCo (n = 138), and Danone (n = 113) had the greatest number of memberships, indicating strong centrality in coordinating the network. We found that this network operates at all levels, yet key actors now predominantly coordinate globally through multistakeholder channels in GFG. The most common interest group types were sustainability/corporate social responsibility/multistakeholder initiatives, followed by branding and advertising, and food manufacturing and retail. Most corporate interest groups are headquartered where they can access powerful government and GFG decision-makers, nearly one-third in Washington DC and Brussels, and the rest in capital cities of major national markets for UPFs.
Conclusions
The UPF industry, and especially its leading corporations, coordinate a global network of interest groups spanning multiple levels, jurisdictions, and governance spaces. This represents a major structural feature of global food and health governance systems, which arguably poses major challenges for actions to attenuate the harms of UPFs, and to realising of healthy and sustainable food systems.
A novel feature dimensionality reduction method for gearbox fault diagnosis with HMSDE, DANCo-DDMA and KELM
Authors: Huang Peng , Gu Yingkui , Qiu Guangqi
Published: December 2023

This paper proposes a gearbox fault diagnosis method with HMSDE, DANCo-DDMA and AOA-KELM. Firstly, the raw HMSDE features are extracted from the raw time domain signals, then, the intrinsic dimension of the HMSDE features is estimated by DANCo, and the extracted HMSDE features are dimensionality reduction by DDMA for eliminating the redundant information. Finally, AOA-KELM is used to classify the reduced HMSDE features. Two experiments are used for verifying the effectiveness and practicality of the proposed gearbox fault diagnosis method, and the results showed that the HMSDE feature has exhibited better characterization performance for the operating state and real behavior of the mechanical system compared with MMSDE, HSDE, and RCMSDE. The AOA-KELM classifier has reached 100% classification accuracy by inputting the reduced HMSDE features, and has achieved a maximum classification accuracy with a minimum fluctuation among LSSVM, RF, KNN, and SOF classifiers, indicating that the proposed method is effectively realized the gearbox fault diagnosis under different working conditions.
Complete uterine rupture in the second trimester of pregnancy and covered by greater omentum to stop bleeding：a case report
Authors: Huang Jia-Zhen , Sun Hai-Yan
Published: December 2023

Background: Uterine rupture usually occurs during delivery, acompany with abnormal fetal heart rate, acute blood loss and hemorrhagic shock. But in our case, the rupture happened on the 20th weeks, the location of uterine rupture was not at common surgical incision, and because of the rupture was covered by the greater omentum, the patient didn’t have severe tearing pain, hypovolemic shock, significant decrease in hemoglobin, vaginal bleeding, and normal fetal heart rate. It was a situation that was easy to miss diagnosis and cause serious maternal complications.
Case presentation: A 24-year-old G2C1 pregnant woman was admitted to our hospital due to "20 + 5 weeks of menopause, epigastric and right lower abdominal pain with nausea and vomiting for 6 days". The patient underwent laparoscopic exploration, and During the laparoscopic exploration: the appendix, intestine, spleen, ovary and other abdominal organs were normal, we only found the fundus of the uterus was adherent to the greater omentum, and the remaining uterus was smooth. Only by decisively separating the greater omentum from the position of close adhesion with the uterus can the rupture be seen. After separating, the amniotic sac ruptured naturally, a male stillborn fetus was delivered through the rupture and we suture the rupture.
Conclusions: For the first and second trimester of pregnancy, abdominal pain is the only major clinical symptom of uterine rupture, and the pain is non-specific, starting a few hours to a few days before the diagnosis. Uterine rupture usually happens after uterine surgery, placental implantation, improper use of uterine contraction drugs, and obstetric surgical procedures. These suggest that uterine rupture should be considered in the diagnosis of all pregnant women with acute abdomen pain. The greater omentum as a source of resident inflammatory cells and stem cells that can be used to participate in the local control of infection, wound healing, and tissue regeneration. If patients’ symptom is untypical, we should take attention to the greater omentum’s influences.
De novo inverse materials design by combining optimization algorithm, universal potential and universal property model
Authors: Yin Wan-Jian , Cheng Guanjian , Gong Xin-Gao
Published: December 2023

We present a de novo inverse materials design (DNID) approach that fully automates the materials design for target physical properties, without the need to provide atomic composition, chemical stoichiometry, and crystal structure in advance. Here we used density functional theory reference data to train a universal machine learning potential (UPot), and transfer learning to train a universal bulk modulus model (UBMod). Both UPot and UBMod were able to cover materials systems composed of any elements among 42 elements. Interfaced with optimization algorithm and enhanced sampling, the DNID is applied to find the materials with the largest cohesive energy and the largest bulk modulus, respectively. NaCl-type ZrC was found to be the material with the largest cohesive energy and many other new materials were discovered to have the strong atomic cohesion, such as C, TiC, and ZrO2. For bulk modulus, diamond was identified to have the largest value and many other new carbon prototypes, several carbon borides and carbon nitrides were found to have large bulk modulus close to diamond. The DNID approach is applicable to design the materials with other multi-objective properties with accuracy limited principally by the amount, reliability and diversity of the training data. It provides a new way for the inverse materials design with other functional properties for practical applications.
Physical and Structural Characterization of Bis-Acryl Composite Resin
Authors: Guardado Wendy E. Rodríguez , Muñoz Eric M. Rivera , Bello Janeth Serrano , Pérez Marco A. Álvarez , Pérez Ruben A. Domínguez , Valdés Elias Nahum Salmerón , Vázquez Febe C. Vázquez , Cuevas Osmar A. Chanes , Malo Beatriz Millán , Ledesma Carmen Leticia Peza , Prado Rodrigo Correa
Published: December 2023

Objective
To determine if the chemical and structural characteristics could cause to increase the fracture resistance using four bis-acryl resins Luxatemp, Protemp, Structur and Telio.
Materials and Methods
Three-points bending by Flexural test, SEM, and FTIR were carried out to compare the Kruskal-Wallis test.
Results
The Kruskal-Wallis test indicated a significant difference in the materials (< 0.0001) that showed higher flexural strength found in Luxatemp, while comparing all bis-acryl resins by Dunn's multiple comparison test indicate that there was no significant difference between Luxatemp VS Structur, and Protemp VS Telio. SEM analysis showed that different sizes of filler particles were observed in all samples, which causes them to present irregular surfaces. By FTIR, typical C = O and CH2 groups were observed corresponding to methyl methacrylate and methylene groups respectively, and different bands located at 1460 − 1350 cm− 1 assigned to pigment materials, stabilizers, and filler particles. In conclusion, a long cross-linkage polymer chain, and the presence of CO3, SiO2 and N-H groups as a fillers particle interacting with OH groups could be the cause of our results.
Conclusion
It is necessary a longer storage under a different condition that would emulate the oral environment and allow us to determine changes in the chemical compounds as well as changes in ultrastructural characteristics related to mechanical properties to identify their correct clinical use.
Clinical Relevance
During the preparation of fixed prosthesis (including individual bridges and crowns) it is important to select the materials that have the best features and properties to predict a successful clinical treatment.
Generation and characterization of cerebellar granule neurons specific knockout mice of Golli-MBP
Authors: Miyazaki Haruko , Ikawa Masahito , Nukina Nobuyuki , Nishioka Saki , Yamanaka Tomoyuki , Abe Manabu , Imamura Yukio , Miyasaka Tomohiro , Kakuda Nobuto , Oohashi Toshitaka , Shimogori Tomomi , Yamakawa Kazuhiro
Published: December 2023

Golli–myelin basic proteins, produced by the myelin basic protein gene, are widely expressed in the neurons and oligodendrocytes of the central nervous system. Previous reports have shown that Golli–myelin basic protein is necessary for myelination and neuronal maturation during central nervous system development. In this study, we established Golli–myelin basic proteins–floxed mice to elucidate the cell-type-specific effect of Golli–myelin basic proteins knockout–generated conditional knockout mice (Golli–myelin basic proteinsfl/fl; E3CreN), in which Golli–myelin basic proteins was specifically deleted in the cerebellar granule neurons, where abundant Golli–myelin basic proteins were expressed in wild-type mice. To investigate the role of Golli–myelin basic proteins in cerebellar granule neurons, we performed a pathohistological analysis using Golli–myelin basic proteinsfl/fl; E3CreN mice. However, they did not show any morphological changes or degeneration of the major cellular components of the cerebellum. Furthermore, behavioral analysis showed that Golli–myelin basic proteinsfl/fl; E3CreN mice were healthy and did not display any abnormal behavior. These results suggested that the loss of Golli–myelin basic proteins in cerebellar granule neurons does not lead to cerebellar perturbations or behavioral abnormalities. This mouse model could be employed to analyze the effect of Golli–myelin basic proteins deletion in specific cells of the central nervous system and other cell types expressing Golli–myelin basic proteins, such as those of the immune system.
Thermally Stimulated Transformation of Oxygen Atoms between Phase States in a Silicon Single Crystal
Authors: Kalanov M. U. , Sadikov I. I. , Khugaev A. V. , Malikov Sh. R. , Saidov A. S. , Usmanov Sh. N. , Saparov D. V.
Published: December 2023

The high-temperature X-ray diffraction method showed the presence of two phase states of oxygen in the volume of a single crystal of silicon grown by the Czochralski method: a dissolved (interstitial) state in the composition of “quasimolecules” - SiO2 and a chemically bound (precipitate) state in the composition of silicon dioxide - SiO2; the precipitate state of oxygen in the bulk of silicon is in the form of crystalline SiO2(c), and in the near-surface layer of a single crystal in the amorphous form of SiO2(a). The thermally stimulated transformation of oxygen atoms between dissolved and precipitate states of oxygen in crystalline form in the bulk of a silicon single crystal has been established.
Latitude-driven functional trait variations in Zizania latifolia: insights into climate adaptation
Authors: Jiang Hong Sheng , Fan Xiangrong , Wagutu Godfrey Kinyori , Wang Wuchao , Li Wei , Chen Yuanyuan
Published: December 2023

Background
Global warming could have a significant impact on plant adaptation to local environments. Widespread species provide a useful model to examine the population dynamic under climate change. However, it is still unclear how widespread aquatic species respond to rapidly changing environments. Wild-rice Zizania latifolia is an emergent macrophyte widely distributed across East Asia. Here, 28 Z. latifolia natural populations covering above 30 latitudes were transplanted in a common garden.
Results
The growth, photosynthesis and reproduction traits were quantified and compared among populations, and pairwise relationships among geographic, genetic and growth traits were estimated. Results showed that, in the common garden, the high-latitude populations grew in small size indicating weaker competitiveness in warmer temperatures; the low-latitude populations had no sexual reproduction, suggesting that low-latitude individuals stood little chance to migrate successfully to higher latitude. Significantly positive correlations among the distances of genetic, geographic and biological traits for populations indicated that both isolation by distance and isolation by environment models affected the genetic pattern of populations, and phenotypic traits of Z. latifolia populations might be determined genetically.
Conclusions
All our results suggested that, despite widespread, the genetically determined differentiation of Z. latifolia populations causing growth and reproduction traits could not rapidly acclimate to the accelerated increase of temperature, which implies this widespread species could fail to cope with global warming via migration.
Multiple Cystic Brain Infection: A Diagnostic Dilemma of Neurocysticercosis and Intracranial Tuberculoma - Case report
Authors: Chew JX , Tan JK , Ho WC , Arifin NM , Chinnasami S , Amran MH , Lim KC , Kamaludeen S
Published: December 2023

Background: Neurocysticercosis (NCC) is a central nervous system infection caused by Taenia solium, or pork tapeworm, affecting millions worldwide and possibly represents a leading cause of epilepsy in developing countries. NCC may be challenging to distinguish from intracranial tuberculomas, with tuberculosis highly prevalent in developing countries. We highlight the importance of clinical history, including exposure history and neuroimaging, in obtaining an accurate diagnosis to enable prompt treatment.
Case presentation: This case illustrates a 26-year-old gentleman diagnosed with NCC presenting with acute giddiness and headache. Clinical history suggested ingestion of undercooked pork, absence of constitutional symptoms, and neuroimaging demonstrated cerebral lesions with scolex and multiple lesions less than 2cm in diameter on brain MRI. He recovered well following a combination of oral albendazole and praziquantel, with corticosteroids prescribed as adjunct.
Conclusion:
This case highlights the salient features to distinguish NCC from intracranial tuberculoma. Early, accurate diagnosis will enable patients to obtain correct treatment and expedite recovery.
pH-responsive Nanosystems for Targeted Drug Delivery to Glioblastoma Multiforme and MRI-facilitated Monitoring of Content Release
Authors: Mundžić Mirjana , Ultimo Amelia , Lazović Jelena , Mladenović Minja , Pavlović Aleksandra , Gobbo Oliviero , Ruiz-Hernandez Eduardo , Santos-Martinez Maria , Knežević Nikola
Published: December 2023

Despite the current state-of-the-art glioblastoma treatment options, a clear indication of therapeutic delivery and efficacy is still missing, especially in early therapy. Substantial advancements, particularly in the areas of image-guided and targeted therapy of the most aggressive type of brain cancer-Glioblastoma multiforme (GBM), are needed to improve the quality of life and survival rates of patients. Herein we describe a proof of principle study toward developing a novel methodology for non-invasive monitoring of the release of cargo molecules from theranostic nanoparticles. This is achieved by quantifying changes in longitudinal relaxation time (T1) before and after the pH-responsive release of contrast agents for magnetic resonance imaging (MRI), from the pores of GBM-targeted mesoporous silica nanoparticles (MSNs). The pores of MSNs were loaded either with the anticancer drug paclitaxel (PTX) or FDA-approved contrast agent Gadobutrol, and their retention inside the pores was ensured by covalent attachment of β-cyclodextrin monoaldehyde to hydrazine-functionalized MSN, through acidification-cleavable hydrazone linkage. In vitro studies using a GBM cell line revealed that the developed nanoparticles effectively delivered their therapeutic cargo, leading to cell death, which was further enhanced with additional functionalization of MSNs with glioma-homing oligopeptide chlorotoxin (CHX). Furthermore, the changes in T1, occurring in response to the release of GdB from the pores of MSNs were successfully demonstrated by MRI measurements. These results are promising for the development of MRI-based methodology for monitoring and tracking the release of therapeutic content in tumor tissues. It is envisioned that this approach using contrast agent-loaded nanoparticles, before the treatment with the drug-filled analogues, could be applied in the future to provide increasingly personalized clinical management of cancer patients.
Current Status, Challenges, and Future Career Pathways of Diploma-Prepared Nurses from the Stakeholders’ Perspective: A Qualitative Study
Authors: Nasser Seema
Published: December 2023

Background
Researchers have examined the nursing profession in Saudi Arabia and the Kingdom 2030 Vision and highlighted that several issues challenge the nursing profession in Saudi Arabia in terms of nursing shortages, underdeveloped nursing education, and undistinguishable scope of practice. It was highlighted that when viewed within the context of 2030, it is thus clear that there is an urgent demand for policy maker to improve nursing care in Saudi Arabia by attending to the nursing shortage, generating strategies to enhance nursing education, and establishing the scope of practice guidelines. Therefore, retention of diploma-prepared nurses is an urgent matter as well, with the notion of the vast numbers in the nursing workforce. Although the experiences of diploma-prepared nurses have been described in the literature, there is a lack of evidence to support the job career paths for nurses and the retention of diploma nurses in Saudi Arabia. Understanding the current challenges and future trends, and solutions from the stakeholders’ perspective is a critical first step that will retain diploma-prepared nurses in the profession and ultimately lead policymakers to formulate policies to address these issues.
Objective
to generate an empirically derived substantive framework to overcome challenges and develop tailored career pathways for diploma-prepared Nurses from the stakeholders’ perspective.
Methods
Thematic analysis qualitative study and grounded theory method will be employed to produce a detailed description and theoretical analysis of the challenges and future of diploma-prepared nurses.
Results
Several themes emerged, and results generated an empirically derived substantive framework to overcome challenges and develop tailored career pathways for diploma-prepared Nurses from the stakeholders’ perspective.
Conclusion
The generated framework will indirectly enhance the delivery of quality healthcare, as it will stimulate the development and implementation of career path programs to promote a better quality of healthcare delivery for patients.