bluuebunny/crossref_metadata_2025 huggingface dataset:
The Intermediatory Role of Microfinancing: Creating Sustainability and Enhancing Agripreneurship in Developing Countries
Authors: Alao Esther Monisola
Published: January 2023

With GDP growth rate of 8.99% agriculture, contributes 24% to the Nationâ€™s GDP while the entrepreneurial sector contributes 47%, improving the economic base through agri-preneurship is achievable. The study thus examines, â€˜the intermediatory role of Microfinancing, creating sustainability and enhancing agri-preneurship in developing countriesâ€™ through a descriptive survey, with questionnaire administered to 80 purposively selected long-time microfinance banks from 2 geo-political zones. Findings indicated that microfinance banks are closer to the grassroot, yet its financial inclusion does not embrace agriculture; very sparse microfinance presence in rural areas, and agro-policy of micro-finance banks should be all-inclusive. Persistent inflation affects the value of loan (Mean 3.1667); Relationship exists between microfinancing and customer growth with 62.3% correlation which is significant at 5% level. Equally, a positive relationship subsists between microfinancing and agri-preneurship depicting a possible link for agripreneurship Vision 2020. The study recommended that new microfinance strategies that can enhance economic growth must be seriously pursued. Efficient linkage to stakeholders within and outside the microfinance system require best practises by managers. Microfinancing targeted at rural agri-preneurship development is suggested
A Conceptual Review of the Challenges of Effective Tax Collection from the Informal Sector in Kano, Nigeria
Authors: Kofar Wambai Usman Sani , Derashid Chek , Ibrahim Idawati
Published: January 2023

The informal sector is often referred to as unregulated financial undertakings and poses a serious challenge to government in relation to tax revenue collection. The main issue of concern is why a wide gap exists between the actual tax collections from the informal sector and the potential tax that should be collected. Thus, the main aim of this study is to identify and examine some of the challenges militating against effective tax collection from the informal sector in Kano State, Nigeria. The paper is literature based, as such, it critically examines current literature on tax collection. It was discovered that issues such as reliance on cash based transactions, absence of required records and weak tax laws are some of the challenges preventing effective tax collection from the informal sector. It is therefore recommended that tax collection from the informal sector could be enhanced when government educates the informal operators, strengthens tax laws, emphasize on adequate records keeping and simplify the formalization procedures.
Effect of Tax Rates, Penalty Rate, Detection Probability, Cost of Compliance, Royalty Rates, Environmental Regulations, and Petroleum Profit Tax Compliance the Moderating Role of Trust in Government: A Conceptual Framework
Authors: Yaâ€™u Abba , Saad Natrah , Masâ€™ud Abdulsalam
Published: January 2023

The paper presents a theoretical framework on the moderating effect of trust inauthority on the relationship between tax rates, penalty, detection probability, costof compliance, royalty rates, environmental regulations, and petroleum profit taxcompliance. The objective of the proposed framework is to expand the Allinghamand Sandmo (1972) model of tax compliance by adding two more predictor variablesrelevant to the oil and gas industry (royalty rates and environmental regulations), andmoderating variable (trust) to better explain the relationship. Allingham and Sandmo(1972) model received a lot of criticisms for not considering other non-human factorsthat can help in determining taxpayersâ€™ compliance behavior, hence the expansion ofthe model to include new variables, purely non-human factors which are relevant to theindustry in question. A thorough search of the following databases: Scopus database,Web of Science, Emerald, Google Scholar, among others was conducted to come upwith the relevant and related literature on the subject matter. Providing empiricalevidence through validation of this framework would have important implicationsfor policymakers in host oil and gas producing countries, oil and gas operators, thedeterrence theory as well as future research.
Unveiling the Determinants of Work-Related Stress in the Policing Occupation
Authors: Mohd Zin Md. Lazim , Ibrahim Hadziroh , Mohd Noor Mohd Hafiz , Ahmad Umair
Published: January 2023

The present study attempts to provide empirical evidence on the relationship betweenworkload, working conditions, role conflict and job stress among the Royal MalaysianPolice (RMP) Personnel. A survey among 178 RMP from six departments at one XYZPolice District in Selangor was conducted. Self-reported measures for all variableswere used to obtain data pertaining to determinants of job stress. Multiple regressionwas employed to investigate three hypotheses that postulated significant positiverelationships between workload, working conditions, role conflicts and job stress.The regression results found that workload and working conditions have positiverelationships with job stress. However, role conflict did not significantly influence jobstress. Plausible justifications for the relationships between workload and workingconditions and job stress were discussed. The study provides a foundation for discussingboth theoretical and managerial aspects of policing occupation.
Spatial Analysis of Changes in the Demographic Characteristics of the Cres-Lošinj Area Using the GIS Model
Authors: Hamzić Marta
Published: January 2023

The paper aims to carry out a spatial analysis of the changes in selected demographic characteristics of the Cres-Lošinj area using the GIS model. For this purpose, data from all censuses carried out so far (1857−2021) were used, which were primarily analyzed cartographically by using Mean Center and the Standard Deviational Ellipse (Directional Distribution) spatial analysis methods, which are an integral part of the basic software package ArcGIS Desktop version 10.0 produced by ESRI. Tabular and graphical appendices were used to additionally complement the analyses. The analyses were carried out on three levels: the level of the Cres-Lošinj area as a whole, the individual level of the Town of Cres and the Town of Mali Lošinj, and the level of settlements. For the area of Cres-Lošinj as a whole, the results showed a tendency of the mean center of the population moving towards the north in the 1857−1948 period, then towards the southwest in the 1948−1991 period, while in subsequent censuses the tendency was again towards the north. Among the local self-government units, a common feature of the movement of the mean center of the population is that in the observed period (1857−2021), and particularly the last observed year (2021), the mean centers of the population are very close to the center of the town/municipality. Using the standard deviational ellipse (directional distribution) method, it was determined that larger settlements (Mali Lošinj, Cres and Veli Lošinj) have an increasing influence on the population direction, and it was determined that the population is concentrated closer to the larger settlements, i.e. to the centers of local self-government, while at the same time the influence on the directional distribution of the population of a large number of small settlements in the northern part of the research area decreased due to an increasing reduction in the number of inhabitants. The GIS model used in this study is suitable for researching the complexity of the demographic dynamics of the so-called of small populations because it enables an analysis at multiple spatial levels and contains methods of spatial analysis that use absolute numbers.
Inclusive and Exclusive Understanding of the Doomsday Prediction Hadith
Authors: Nawir Mohammad
Published: January 2023

This study aims to compare the understanding of the hadith about the signs of the Day of Judgment in order to achieve an accurate understanding of the hadith of the Prophet, this research is a literature study using an analytic descriptive approach. This research is based on several pro and contra arguments related to the understanding of end-time hadith, groups or figures who welcome it with a similar response, including: the Shia sect, which thinks that at the end of time an imam named Imam Mahdi will be born who will lead the end-time ummah against all forms of abuse that is currently happening, this is what the Shi'a followers have been waiting for. Zulkifli Ali, with his argument that there is no other way than for the Muslim community to prepare themselves to welcome the arrival of Imam Mahdi and Dajjal, and the signs expressed in various hadith narrations have occurred a lot. Muhammadiyah organization, which responds to oblique hadiths that mention the appearance of an imam at the end of time (Imam Mahdi) with the argument that such an understanding comes from Shia groups that do not come from the prophet. Fazlurrahman argued that almost all hadiths that are technical in nature cannot be accounted for their authenticity to the prophet, including hadiths that discuss signs of the doomsday. This research is very urgent, because the debate over the arguments studied is directly related to facts that lead to disruption and even negative accusations against hadith speakers (Prophet Muhammad).
Between Ushlub Tahlili and Maudhu‘i: Which One Is More Relevant to Nowadays?
Authors: Haq Sansan Ziaul , Irham Irham , Basith Yudril
Published: January 2023

The demand for renewal of the methodology of Qur’anic interpretation is a modern phenomenon. The Qur’an as the main source of Islamic teachings is fixed and does not change, but on the other hand, the dynamics of the times require the Qur’an to answer new problems. This is what then encourages the experts to review how to present the guidance of the Qur’an in the current context. Among these various updates are those related to the techniques of presenting interpretations (asalib al-tafsir). This paper specifically examines and compares the two most popular techniques of Quranic interpretations, namely ushlub tahlili and ushlub maudhu'i. Regarding these two techniques, some experts consider that the second is more relevant to the demands of nowadays than the first. However, this paper analytically concludes that these two techniques cannot be compared to negate each other because each has advantages and disadvantages. In fact, this two ushlub are still in use, with various adjustments, so that they are considered relevant in the midst of the times.
Eyeshadow as a Fashion Cosmetic in Review of Hadith
Authors: Mulyani Welia , Febriyeni Febriyeni
Published: January 2023

The use of eyeshadow using itsmid has become a habit carried out by the Prophet Muhammad and of course this is also a recommendation for his people. In a hadith narrated by Ibn Majah it is stated that kohl made from itsmid material can clear the eyes and lengthen the eyelashes. Today, eyeshadow is more widely used by women as a fashion in the world of cosmetics and beauty. The materials used have also undergone variations, no longer made from itsmid. This study examines the hadiths of wearing eyeshadow, and reviews the contextualization of this hadith using eyeshadow as a fashion. This type of research is literature with takhrij and ma'anil hadith approaches. The results of the study show that the hadiths about celak are listed in six source books, namely sunan Abu Dawud, sunan at-Tirmidhi, sunan Ibnu Majah, sunan ad-Darimi, sunan an-Nasa'i, and musnad Ahmad bin Hanbal. The best kolak is itsmid which comes from the country of Ashbahan in the form of very black, almost reddish stones. Itsmid celak functions as an eye medicine, which sharpens eyesight, grows eyelashes. However, based on the purpose and benefits of wearing kohl, using kohl other than itsmid is permissible, as well as for fashion purposes, as long as it's not excessive, which doesn't harm eye health.
The advertisement call of Mannophryne lamarcai Mijares-Urrutia et Arends 1999 (Anura: Dendrobatidae)
Authors: Cardozo-Urdaneta Arlene , Sánchez-Mercado Ada
Published: January 2023

The genus Mannophryne includes 19 described species from Venezuela and two species from Trinidad and Tobago. We described for the first time the advertisement call of Mannophryne lamarcai, an endemic and Critically Endangered species from the Cerro Socopó at western Venezuela. M. lamarcai was spatially restricted in appropriate habitats. Males were calling actively on top of rocks and fallen trucks, along small streams. Calling activity was registered between 13:00 - 19:00 h. The call of M. lamarcai comprises a single note arranged in call groups of 37 to 202 notes (130.35; ± 45.62) with five harmonics. The second harmonic is the dominant with a frequency band of 3.7 kHz. The call lasts the duration of one note from 0.01 to 0.03 s (0.033 ± 0.006), while the call group lasts up to 16 s (5.88 – 28.34; ± 5.51. Call bouts were arranged in groups of eight trains (6 – 13; ± 1.73), with an inter-note gap of 0.08 s (0.05 to 0.33; ± 0.04). The inter-note interval was longer during the first 4.5 s of the call group than later.
Investigation on Losses with Various Emerging Core and Winding Materials in a High Frequency Planar Transformer
Authors: Venugopal Arya , Robert Femi
Published: January 2023

In this work, various emerging core and winding materials suitable for a high frequency planar transformer (PT) has been analyzed and compared. Core and winding materials used in a transformer has a significant effect mostly in the core and winding losses of the transformer. Emerging core materials like amorphous and nanocrystalline cores were compared against the conventional ferrite core. The results obtained showed that core losses were reduced by around 48.14% on using amorphous or nanocrystalline cores instead of the conventional ferrite cores. Typical copper and aluminum windings were also compared with emerging materials like carbon nanotube (CNT), Cu/CNT and Al/CNT. Winding losses was found to be the lowest on using CNT windings instead of metal windings like Cu or Al, or metals composite windings like Cu/CNT and Al/CNT. A winding loss reduction of about 56.2% was seen with CNT windings. Thus, it was concluded that the best possible core and winding combination was amorphous or nanocrystalline cores with CNT windings, as they give the lowest possible core and winding losses for the PT. Finite Element Analysis was carried out on a 2-kW PT operating at 100 kHz frequency, with the software Altair FLUX for the analysis.
« Stella maggior della cadente notte » : nocturnes mélancoliques à la fin du dix-huitième siècle
Authors: Bianco Francesca
Published: January 2023

L’essai reconstruit le milieu culturel italien de la deuxième moitié du dix-huitième siècle et en souligne les caractéristiques par rapport aux contextes européens. Si de nombreuses œuvres allemandes ou anglaises se servent souvent du français avant d’être traduites en italien, d’autres passent directement à l’italien. C’est le cas des Poesie di Ossian traduites par Melchiorre Cesarotti, œuvre qui est aussi une expérience linguistique et culturelle, puisqu’elle se propose comme fenêtre ouverte sur un monde complètement nouveau, dont la mélancolie et la nuit représentent des fondements thématiques cardinaux. L’expérimentalisme linguistique de Cesarotti trouve dans sa traduction un point de rupture avec la tradition classique, qui ouvrira la voie à la grande poésie romantique.
“Dietro le porte”: “Lo spavento notturno” di Giacomo Leopardi, i terrori della notte e la morte in culla tra “errori popolari” e nosologia medica
Authors: Camilletti Fabio
Published: January 2023

Testo peculiarmente instabile, nella lunga storia editoriale della poesia leopardiana, l’idillio che per convenzione denominiamo “Odi, Melisso” porta anche, negli anni 1819–26, il titolo “Lo spavento notturno.” L’accostamento del sostantivo “spavento” e dell’aggettivo “notturno” non è privo di echi per un’analisi storico-culturale del pensiero leopardiano e dei modi in cui questo affronta temi che sono al cuore della riflessione post-illuminista: da un lato, la natura e l’origine della paura; e, dall’altro, la metamorfosi nel rapporto tra l’essere umano e la notte. In particolare, in questa sede, suggerirò la possibilità che il lessema possa obliquamente rimandare alla definizione clinica del disturbo infantile noto – ancora oggi – come pavor nocturnus; nella conclusione, indicherò come tale congettura possa ulteriormente confermare l’idea dell’idillio come trascrizione verbale e dialogica di un’esperienza quintessenzialmente pre-verbale.
Tildrakizumab for the treatment of exfoliative cheilitis
Authors: COWAN Timothy , ABU ALRUB Nada , WİLSON Anna , MAKHİJA Mani , MURRELL Dedee
Published: January 2023

Exfoliative cheilitis is an inflammatory condition that can significantly impair quality of life. This is the first reported case of an interleukin-23 inhibitor, tildrakizumab, for the treatment of a chronic, refractory case of exfoliative cheilitis.
Treatment of pemphigus beyond rituximab: chimeric autoantibody receptor T cell (CAAR-T cell) therapy
Authors: ERMİŞ AKKUŞ Hande
Published: January 2023

Pemphigus vulgaris is a rare, life-threatening, autoimmune bullous disease. After decades of systemic corticosteroids and corticosteroid-sparing immunosuppressants being used to control the disease, the efficacy of rituximab has been shown in randomized controlled studies. Hence rituximab constitutes the first-line treatment for mild and moderate-to-severe pemphigus vulgaris according to the most recent European S2K guideline. Despite promising results with rituximab, there is still no disease-specific treatment available. In that regard, chimeric autoantibody receptor therapy (CAAR-T cell therapy) is under the spotlight utilizing a cutting-edge technology.
Giant wart on the tongue
Authors: ÖZCANLI Adil , HASBAL Nuri Barış , ARMUTLU Ayşe , ALTUNTAŞ Ozan , VURAL Seçil
Published: January 2023

Verruca vulgaris is a benign infection caused by the human papillomavirus (HPV). The lesions appear primarily on the cutaneous surfaces; however, mucosal involvement is less frequent. The typical presentation is asymptomatic papules varying in size and number. The differential diagnosis includes a diverse list of benign and malignant conditions. Herein, we present a 65-year-old male patient with an asymptomatic cauliflower-like mass on the tongue incidentally observed during internal medicine physical examination. The excisional biopsy revealed verruca vulgaris, and no new lesions were detected in the follow-up.
Development of Resistant Starch-Pectin Microsphere for Improving Oral Colon-specific Drug Delivery of 5-Fluorouracil
Authors: Ema Nushrat Jahan , Hossain S M Rakibul , Shahriar Saimon , Islam Muhammad Rashedul , Chowdhury Jakir Ahmed
Published: January 2023

Conventional chemotherapy is ineffective for colorectal cancer as the drug moiety does not reach its intended site. 5-Fluorouracil (5-FU) microspheres aimed at colon-specific drug delivery have been developed by using the solvent evaporation technique in this study. The influence of utilizing different percentages of resistant starch-pectin polymer on the drug loading, encapsulation efficiency, and release behavior of the drug was investigated. The characterization of prepared microspheres was done by shape, surface morphology, drug loading, encapsulation efficiency and in vitro drug release studies. Drug-polymer interactions and drug stability were investigated by Differential Scanning Calorimetry (DSC) and FTIR spectroscopy. The 5-Fluorouracil polymeric microspheres that were formulated utilizing a resistant starch (RS) and pectin polymer displayed ideal physicochemical properties and spherical particles. The targeted microspheres demonstrated a high drug loading, encapsulation efficiency, and a satisfactory drug release pattern over the time period of 8 hours. Studies on drug release conducted under conditions that simulate stomach to colon transit have demonstrated that the drug was prevented from being released in the physiological conditions of the stomach and small intestine. Creating a new multiparticulate system using RS-pectin microspheres in order to forecast the protection that the combination might provide to the dosage form that will ensure localized drug release in the colon. Finally, it was found that the 5-Fluorouracil polymeric microsphere is a suitable microcarrier for effective colon-specific drug delivery tools with increased chemotherapeutic efficacy.
Bangladesh Pharmaceutical Journal 26(1): 36-44, 2023 (January)
Decision Making System Using Fuzzy Mamdani in Detecting Cholestrol Disease
Authors: Novita Nanda , Anisa Yuan , Zuanda M.Khafi , Eliska Eliska , Widiantho Yuri
Published: January 2023

Cholestrol is a physical property of natural substances in the form of fat which is useful as an essential building material for the body for the synthesis of important substances such as cell membranes and insulation materials around nerve fibers. In addition, it is useful for sex hormones, kidney children and bile acids. High cholesterol levels or hypercholesterolemia in the blood triggers hypertension. This is because high cholesterol is the cause of blockages in peripheral blood vessels that reduce blood supply to the heart. Based on these studies, it shows that the influence of obesity (overweight) and blood pressure has a role in the risk of cholesterol disease. Based on the rule view, it can be seen that the cholesterol level is 210 or it can be said that it is in the alert category, it can be seen for blood pressure 100.6 and BMI 31.8.The fuzzy mamdani method is often also known as the min-max method. Where it uses min or minimum on the implication function and max or maximum on the composition between implication functions. In its application, the madani fuzzy method uses 4 stages, namely the formation of fuzzy sets, application of implication functions, rule composition, defuzzification. This research uses a simulation method of calculating cholesterol. This research analyzes using fuzzy mamdani and matlab software assistance.
Análisis del aprendizaje basado en proyectos y estrategias colaborativas en carreras de ingeniería durante la pandemia de la COVID-19. Caso: Curso de Teoría de Control I
Authors: Rua Esteban , Henríquez Ricardo , Chang Jordán Ignacio Jacinto
Published: January 2023

La pandemia por la COVID-19 provocó que en el sector educativo se pasara de las clases en modalidad presencial a la no presencial, producto de las medidas de bioseguridad. Luego, garantizar el aprendizaje significativo a distancia se convirtió en una necesidad esencial. En este documento se analiza la aplicación del aprendizaje basado en proyectos (ABPr) combinado con estrategias colaborativas de aprendizaje y sus efectos en la eficacia de la educación superior en el curso de Teoría de Control I de la Facultad de Ingeniería Eléctrica de la Universidad Tecnológica de Panamá. El análisis demostró que la metodología es una herramienta complementaria que facilita y potencia un ambiente de aprendizaje que desarrolla en gran medida el pensamiento crítico y reflexivo en los estudiantes, cualidades de las que debe gozar todo profesional de la ingeniería. Los resultados demostraron que los proyectos desarrollados por estudiantes pueden convertirse en unidades de autoaprendizaje para otros estudiantes, brindando una retroalimentación directa de los conceptos vistos en el curso.
El problema de secuenciamiento parcialmente flexible, multiobjetivo, basado en un algoritmo genético de selección natural
Authors: Álvarez González Monserrat
Published: January 2023

En el presente trabajo se buscó resolver un problema de secuenciación parcialmente flexible, energéticamente eficiente, con tiempos de preparación dependientes de la secuencia, penalizaciones de costos por finalización temprana y tardía y mantenimiento preventivo. Estas variables y objetivos fueron seleccionados porque se considera que estos son los que tienen mayor impacto en el día a día de las empresas. Para la solución se propone un algoritmo genético compatible con las variables propuestas y capaz de obtener una solución de manera eficiente. Para comprobar el funcionamiento de la propuesta, se prueba el algoritmo con una simulación que combina datos de otros trabajos con información ficticia. El algoritmo encontró una solución para las tres funciones objetivo propuestas a partir de la información de cinco generaciones de datos. El resultado fue un cronograma óptimo, la duración total y el costo de los envíos tardíos y los adelantos que no se pudieron evitar.
Quality of Information in YouTube Videos on Penis Enlargement Surgery
Authors: Karakol Perçin , Tas Tuncay
Published: January 2023

Background: An increasing number of patients and their aesthetic curiosity are causing the online questioning of penis enlargement surgery (PES). Although there is a wealth of healthcare information about PES on the internet, the quality of PES-related information on YouTube, the most visited online video streaming service, has not fully known. It is aimed to evaluate the quality of information about PES in YouTube videos. Materials and Methods: In January 2021, we cross-sectionally performed YouTube search using the keywords "penis enlargement surgery", "penis lengthening surgery", or "penis thickening surgery". We sorted the videos as reliability in terms of containing scientifically proven information by 1 urologist and 1 plastic surgeon. Irrelevant, non-Turkish, and silent videos were not included. Video demographics were analyzed based on the quality and source of the video. A 5-point global quality scale, a 5-point reliability (DISCERN) tool, kappa statistic, the intraclass correlation coefficient, and descriptive statistics in the form of proportions and percentages were used. Results: A total of one-hundred PES videos published on YouTube between 2015-2021 were searched. Thirty-nine of these videos were removed due to duplicate, irrelevant, lack of sound or misleading information. Deceptive videos had a significantly higher number of likes than useful videos. On the other hand, useful videos had significantly more views than misleading videos. Useful videos had a higher DISCERN score compared to misleading videos. The fact that the uploader was sourced by professionals and doctors working at universities significantly contributed to the usefulness of the videos. Conclusion: As searching for information about PES on YouTube, patients are exposed to low-quality and confusing videos. Complexity in the number of views and likes could make accessing the informative PES video difficult. It may be recommended that patients prefer PES videos created by professionals.
Bilateral Pudendal Thigh Flap In The Creation of A Neovagina and Restoration of Utero-Neovaginal Continuity – A Case Report
Authors: OGUNDIPE Kolawole Olubunmi , ENOCH Elizabeth Evelyn
Published: January 2023

The pudendal thigh flap is a sensate flap based on the posterior labial artery, which has shown great versatility in the reconstruction of genital anomalies as well as genital oncologic reconstruction. This report showcases the creation of a neovagina with the restoration of uterovaginal continuity in a 12-year-old girl who had vaginal atresia. She presented with concealed menstruation and cyclical abdominal pain and had a creation of a neovagina with utero-vaginal continuity using a bilateral pudendal thigh fascio-cutaneous flap. Post-operatively, she attained normal menstrual flow and a sensate neovagina with a satisfactory vaginal canal depth. Partial wound dehiscence of the flap donor site was managed with dressing and healing by secondary intention. Even in new centres, the pudendal thigh flap remains a versatile flap for managing vaginal atresia.
The Mediastinal Ganglioneuroma in a Case Operated on in Mali
Authors: DOUMBIA Modibo , DIARRA Check Mansour , DIARRA Baba Ibrahima , COULIBALY Souleymane , KONE Salif , LY Madani , DIALLO Binta , TRAORE Salia , Koita Siriman , TOGOLA Birama , DIARRA Mamadou B , Togo Seydou , Ouattra Moussa Abdoulaye , Kamaté Bakourou , COULIBALY Bréhima , Yena Sadio
Published: January 2023

Ganglioneuroma is a benign tumor of the sympathetic nervous system belonging to the neuro-cristopathies, the pathogenesis of which remains less well known. In Mali, no mediastinal ganglioneuroma has been published in the literature. The diagnosis was confirmed by anatomopathological examination. We report a case of mediastinal ganglioneuroma in a 14-year-old female patient and review the literature.
Two Cases of Primary Leiomyosarcoma of the Vagina: Histomorphologic Presentation with Review of the Literature
Authors: FG Mouamba , RG Buambo , L Mozoma , B Samba , GC Bizib , K Mavoungou , B Senga , JF Peko
Published: January 2023

Leiomyosarcoma is a rare lesion and its localization to the vagina extremely rare. We report two cases of primary leiomyasarcoma of the vagina, involving the posterior wall, in a 46-year-old woman and a 56-year-old woman, describing their histomorphological and evolutionary characteristics, with review of the literature.
Manajemen Pembelajaran Dalam Meningkatkan Prestasi Belajar Siswa
Authors: Sofiyah Siti
Published: January 2023

The purpose of this research is to provide information on planning, implementing and evaluating learning to improve student performance. This study uses qualitative methods. The survey was conducted from March to June 2022 at MIN 3 Purworejo. Informants for this survey were madrasah leaders, teachers and students. Data collection techniques using interviews, observations and documentation. Validity of data using triangulation. Data analysis uses the Miles & Huberman model, which consists of data collection, data reduction, data display, and inference. The results of this study show that: (1) Teachers implement lesson plans by creating curricula, annual programs, semester programs, KKM, time allocation, learning implementation plans, support and enhancement programs. (2) The delivery of learning is performed by teachers, including preparatory activities (perception), core activities (including exploration, elaboration, and validation), and conclusion activities. Teachers use learning media and apply different learning methods. (3) Evaluation of learning is done by teachers and heads of madrasas. Teachers implement assessment systems in the form of learning processes and learning outcomes. This includes her three areas: cognitive, psychomotor, emotional. Madrasah principals regularly monitor teachers to improve their performance
Manajemen Pendidikan Aqidah Akhlak MTs Al Munawwarah di Lingkungan Eks Lokalisasi Pekerja Sex Komersial (PSK) Desa Slarang Kecamatan Kesugihan Kabupaten Cilacap
Authors: Sudadi Sudadi
Published: January 2023

The purpose of this study is to describe the management of MTs The Impact on Students Who Come from the Ex-Localization of Slarang Commercial Sex Workers (PSK) in the 2019/2020 Academic Year. This research was conducted with a qualitative approach. The subjects of this study were the principal, teachers, and students. Data collection techniques from this study using the method of observation, interviews, and documentation. The results of this study indicate that, 1) Learning planning by teachers is carried out by compiling annual programs, semester programs, developing learning syllabus, and developing lesson plans. 2) Organizing learning is carried out by the teacher, namely: structuring classrooms, structuring students, using learning resources, using learning media, and using facilities and infrastructure. 3) Implementation of learning is the teacher carrying out learning activities including preliminary activities, core activities, and closing activities. 4) Learning evaluation is the principal of madrasah providing guidance, assistance, supervision and assessment on problems related to the technical implementation and development of teaching education in the form of improving teaching education programs and activities to create teaching and learning situations. Meanwhile, the teacher evaluates learning through process assessment and results assessment. Process assessment is carried out on student participation both individually and in groups during the learning process. Assessment of results is carried out at the middle and end of the semester. 5) Reporting of learning outcomes that the content of reporting learning outcomes includes things such as student learning profiles at madrasah (academic, physical, social and emotional), student participation in activities at madrasah (active, moderate, insufficient or inactive), progress of results student learning during a certain learning period, appeal to parents.
Etnomatematika Sebagai Inovasi Pembelajaran dalam Mengintegrasikan Nilai Kearifan Lokal dan Konsep Matematika untuk Meningkatkan Hasil Belajar Siswa Madrasah Ibtidaiyah
Authors: Arif Sofiyudin , Mahmudah Umi
Published: January 2023

This study aims to analyze the effectiveness of the implementation of ethnomathematics learning in improving student achievement in Islamic elementary schools. This research is focused on the learning outcomes of the flat wake concept. Internalization of local wisdom values in the concept of mathematics as an innovation carried out by educators in understanding students as well as providing direct learning experiences in the real world. This research applies a quantitative approach. A total of 25 students were sampled in this study which were taken randomly. Methods of collection and use of test sheets. Data analysis used paired sample t-test. The results of the hypothesis test indicated that the H0 decision was rejected (tcount = 6.297, ttable = 2.069, and and p-value = 0.000). These results indicate that there are differences in the average results of mathematics when learning mathematics internalizes local traditional values in society. These results have implications that the implementation of ethnomathematics can improve mathematics learning achievement.
DYNAMICS OF INDONESIAN LABOR COOPERATION RELATIONSHIP WITH SAUDI ARABIA
Authors: Venisha Leriche
Published: January 2023

Each country will meet each other and work together to meet the needs of their respective countries. In bilateral relations, Indonesia cooperates through an agreement on the protection and placement of domestic sector workers between the Republic of Indonesia and the Kingdom of Saudi Arabia with an effort to agree on a moratorium on sending Indonesian Migrant Workers (PMI) to Saudi Arabia. The problem discussed in this study is the relationship between Indonesia and Saudi Arabia regarding the protection and legal remedies for Indonesian workers in Saudi Arabia. This research uses normative juridical mode. Methods of collecting information from books, magazines and the internet such as relations between Indonesia and Saudi Arabia. The results show that the governments of Indonesia and Saudi Arabia have agreed on a Memorandum of Understanding (MoU) on the placement and protection of Indonesian Migrant Workers in Saudi Arabia. The effect of the signing of this Memorandum of Understanding is to guarantee the protection of the rights and welfare of Indonesian Migrant Workers who work there.

Keywords:Cooperation, Indonesia - Saudi Arabia, Employment, International Law
DAMPAK PEMBELAJARAN PASCA DARING TERHADAP SIKAP SISWA SEKOLAH DASAR DI SDN 95 PEKANBARU
Authors: Qalbina Fithrah , Witri Gustimal , Antosa Zariul
Published: January 2023

Penelitian ini bertujuan untuk mendeskripsikan dampak pembelajaran pasca daring terhadap sikap siswa kelas tinggi Sekolah Dasar Negeri 95 Pekanbaru. Pembelajaran pasca daring merupakan proses belajar mengajar yang pelaksanaan pembelajarannya secara tatap muka kembali. Penelitian ini menggunakan metode kuantitatif. Teknik pengumpulan data yang digunakan yaitu teknik kuesioner dan wawancara, dengan skala pengukuran yang digunakan skala likert. Subjek penelitian adalah siswa kelas IV, V, dan VI Sekolah Dasar. Hasil dari penelitian ini adalah Dari 6 Indikator sikap jujur, disiplin, tanggung jawab, percaya diri, santun dan toleransi  didapatkan skor dengan rata-rata 3,24 kategori baik.. Berdasarkan dari 6 indikator sikap yang berdampak negatif pada indikator sikap percaya diri, hal itu terlihat bahwa sebagian besar siswa tidak berani untuk menampilkan hasil diskusinya, dan bertanya kepada guru.
Case Report: Double Orifice Mitral Valve with Cleft in Anterior Leaflet of Dominant Valve in an Afro-Caribbean
Authors: Williams-Phillips Sandra
Published: January 2023

Double orifice mitral valve (DOMV) is a rare congenital mitral valve (MV) disorder. It is associated with other types of congenital heart disease in 45% of patients, but it has been documented to be isolated with or without noncompaction of the left ventricle. The focused features of this case report are the transthoracic echocardiographic images of an isolated case of DOMV, with an additional rare association of a cleft in the anterior leaflet of the dominant MV presenting as mitral regurgitation in a 13-year-old Afro-Caribbean female.
Emerging Options for Patients with Atrial Fibrillation
Authors: Bell Juliet
Published: January 2023

Dr Jeffrey Weitz chaired the symposium and welcomed Dr Christian Ruff, who discussed and summarised recent results from key trials of new oral anticoagulants (NOACs) in atrial fibrillation (AF) with a focus on edoxaban. Prof Andreas Goette then evaluated the current guidelines for the use of cardioversion in AF treatment and recent findings from NOAC trials. Dr Jack Ansell described the current management strategies for NOACs and the limitations therein, as well as novel reversal strategies for NOACs currently under development. Finally Prof John Camm, co-chair, summed up the use of NOACs as an alternative to warfarin in the prevention of stroke in patients with AF, and closed the meeting.
Biomarker-Based Guideline-Directed Medical Therapy of Heart Failure: The Gap Between Guidelines and Clinical Practice
Authors: Berezin Alexander E. , Berezin Alexander A.
Published: January 2023

Current clinical recommendations provided by the 2016 European Society of Cardiology (ESC) and 2017 American College of Cardiology (ACC)/American Heart Association (AHA)/Heart Failure Society of America (HFSA) are substantially distinguished in the use of circulating biomarkers in the management of heart failure (HF). To date, natriuretic peptides continue being the universal biomarkers used in diagnosis, risk stratification, and prediction of cardiovascular death, all-cause mortality, and HF-related outcomes for patients with both phenotypes of HF. However, biomarkers of fibrosis and inflammation, including soluble suppressor of tumourgenicity 2 and galectin-3, were able to increase predictive ability of natriuretic peptides in HF patients regardless of cardiovascular risk-factor presentation and HF phenotypes. Therefore, there are many various biomarkers describing several pathophysiological processes such as fibrosis, inflammation, oxidative stress, neurohumoral activation, extracellular matrix turnover, and vascular reparation, that play a pivotal role in the natural evolution of HF. This review discusses whether multiple biomarker models are more effective than a single biomarker in improving risk stratification strategies in patients with HF. It emphasises how in routine clinical practice, the multiple biomarker approach to elicit response to therapy of HF and predict clinical outcomes is rare, probably because of the relatively high cost, low affordability, lack of clear recommendations for clinical implementation, and significant disagreements in the interpretation of the data obtained.
Isotretinoin and Psychiatric Effects
Authors: Takci Zennure , Karadag AyseSerap , Burakgazi Yilmaz Hatice
Published: January 2023

Isotretinoin is a vitamin A derivative that has been commonly used by dermatologists for the treatment of acne. Isotretinoin has many dose-related side-effects, which have caused many debates lately, especially related to psychiatric and gastrointestinal issues. Since the introduction of isotretinoin into the market, there have been a growing number of reported cases of psychiatric side-effects, including: depression, suicide, aggression, psychosis, mood swings, violent behaviour, hostility, bipolar disorder, and obsessive compulsive disorder. According to some animal studies, isotretinoin can pass the blood-brain barrier and it may cause serious side-effects. On the other hand, it has been shown that isotretinoin can decrease the psychiatric symptoms of many psychiatric patients. Because a definitive causal relationship has not been established, it remains unclear as to whether isotretinoin therapy leads to psychopathology. In this review article, we evaluate the published articles about the psychiatric side-effects of isotretinoin and discuss the psychopathologic effects of isotretinoin.
Gram-Negative Bacterial Toe Web Intertrigo
Authors: Atzori Laura , Zucca Myriam , Lai Michela , Pau Monica
Published: January 2023

Gram-negative infection of the toe web space is less frequent than dermatophytes and yeasts, but it is more challenging, especially with the involvement of Pseudomonas aeruginosa in relation to antibiotic resistance and the increased risk of potentially lethal complications. Many conditions, other than infections, might initially present with the same clinical features, recognising the common initial damage (intertrigo), due to skin-on-skin rubbing in a moist environment with air entrapment, which is typical of interdigital spaces. Conditions such as contact eczema, atopic dermatitis, and inverse psoriasis, frequently predispose to, and are maintained by, the intertrigo, triggering a vicious circle. The dermatologist is in a lead position to address the correct assessment and management. A careful screening for predisposing factors is necessary: overweight, diabetic, but also athletes or people attending swimming pools, gyms, public showers/dressing rooms, and thermal baths are also at an increased risk of intertrigo of the toe web spaces. Occupational activities other than recreational might be relevant, such as the use of safety shoes or working in wet warm conditions. Incongruous therapy for tinea pedis or contact dermatitis, frequently auto-prescribed, might be among promoting factors altering the microbial ecosystem balance. The aim of this review is to evaluate the main epidemiologic and clinical features of Gram-negative bacteria intertrigo, the role of promoting factors, and the measures taken to treat and prevent this disorder. Appropriate treatment and patient education are crucial to prevent further infection and relapses.
Treatment of Advanced Cholangiocarcinoma: Current Status and Future Perspectives
Authors: Kuhlmann Jan B.
Published: January 2023

Cholangiocarcinoma (CC) is a tumour with a poor prognosis. The treatment of CC is challenging as the tumour is usually diagnosed late and the treatments are not very effective except when complete surgical resection is possible. However in the majority of cases, surgical resection is not possible and palliation is the mainstay of treatment. Currently chemotherapy combining gemcitabine with a platinum agent is the recommended first- line treatment regimen for advanced CC. Since, CCs have only a limited tendency to metastasize locoregional therapy is an interesting approach.

The aim of this short review is to give an update on standard and prospective treatment concepts in advanced cholangiocarcinoma based on a comprehensive review of the recent literature and guidelines.
Treatment of HIV-Associated Burkitt Lymphoma
Authors: Donadoni Giovanni , Bruno-Ventre Marta , Ferreri Andrés J. M.
Published: January 2023

Burkitt lymphoma (BL) is a highly aggressive B-cell malignancy, occurring with increased frequency among patients infected with HIV. For several years, the immunocompromised state of HIV-positive patients was advocated as a sufficient reason to avoid the intensive chemotherapeutic regimens used in HIV-negative BL. However, with the introduction of the highly active antiretroviral therapy (HAART), the subsequent improvement of the immunological state of HIV-positive patients, and the disappointing results of less intensive schedules, investigators began to apply the same chemotherapeutic regimens used as a gold standard in HIV-negative non-Hodgkin lymphoma (NHL), including the use of rituximab. Despite promising results of different schedules in early-phase studies, agreement on the treatment of HIV-positive BL is still lacking, and further trials are needed to define a standard of care. Moreover, new treatment frontiers need to focus on improving the outcome for patients with advanced immunosuppression, unfavourable prognostic features- such as advanced stages and high International Prognostic Index (IPI) scores – and for those with adverse tumour biology.

This paper aims to revise the main epidemiological and physiopathological features of HIV-positive BL, to summarise the most relevant steps in the treatment of affected patients, and to elucidate the role of HAART in allowing HIV-positive patients to be managed with the therapeutic strategies currently used in HIV-negative patients with BL.
Acute-On-Chronic Liver Failure: Applying the PIRO Concept
Authors: Adebayo Danielle , Morabito Vincenzo , Jalan Rajiv
Published: January 2023

Acute-on-chronic liver failure (ACLF), a clinical syndrome associated with a dismal prognosis, occurs acutely in previously stable cirrhotic patients. An important feature of this syndrome is the potential for reversibility if it is recognised early and supportive measures are instituted before multi-organ failure ensues. In response, there have been recent efforts to better define and understand the pathophysiological basis of the condition so as to aid early diagnosis and management. The PIRO concept is conceptually useful as it indicates a distinction between the insult and the response. Interventions that target inflammation may adversely impact on the ability to control the infection, and interventions that target infection may not be useful if pathophysiological process is being driven through inflammation. A classification based on the PIRO concept may allow the categorisation of patients into distinct pathophysiologic and prognostic groups and allow a multidimensional definition of ACLF.
Retrograde Approach for Chronic Total Occlusions: The Importance of Experience and Proctorship
Authors: Stojkovic Sinisa , Zivkovic Milorad , Beleslin Branko
Published: January 2023

Recanalisation of chronic total occlusions has remained suboptimal in the field of percutaneous coronary intervention (PCI). Hopes for a better outcome have been raised since its introduction and evolvement of new techniques, including retrograde approach. Along with conventional antegrade approaches this technique led to a success rate of more than 90% in experienced and chronic total occlusion-dedicated centres. This article focuses on contemporary retrograde approach strategy and the importance of experience and proctorship in PCI of coronary chronic total occlusions (CTO).
Pacemaker-Dependence After Transcatheter Aortic Valve Implantation
Authors: Yildiz Mustafa , Yildiz Banu Sahin , Akin Ibrahim
Published: January 2023

Transcatheter aortic valve implantation (TAVI) has emerged as an alternative for multimorbid patients not suitable for open heart surgery. The vicinity of the conduction system, especially the atrioventricular node and His bundle to the non-coronary and right coronary aortic cusp, predisposes these patients to conduction abnormalities. However, due to the shape of both available transcatheter aortic valves (CoreValve and Edwards SAPIEN valve) these rates are different. To date, there is no clear information about the true rate of atrioventricular block, the significance of left bundle branch block as well as the transient or permanent nature of these conduction disorders. Due to this, the rate of subsequent pacemaker implantation exceeds up to 50%, which itself may be associated with worse clinical outcomes. Thus, there is a need for further data from large-scale series with a glance to the true rate of clinically relevant conduction disorders.