bluuebunny/crossref_metadata_2025 huggingface dataset:
Patient-Reported Outcome Measure for Real-time Symptom Assessment in Women With Endometriosis: Focus Group Study
Authors: van Barneveld Esther , Lim Arianne , van Hanegem Nehalennia , Vork Lisa , Herrewegh Alexandra , van Poll Mikal , Manders Jessica , van Osch Frits , Spaans Wilbert , van Koeveringe Gommert , Vrijens Desiree , Kruimel Joanna , Bongers Marlies , Leue Carsten
Published: October 2021

Background

Symptoms related to endometriosis have a significant impact on the quality of life, and symptoms often recur. The experience sampling method (ESM), a digital questioning method characterized by randomly repeated momentary assessments, has several advantages over traditionally used measurements, including the ability to assess the temporal relationship between variables such as physical, mental, and social factors.

Objective

The aim of this study is to develop an ESM tool for patients with endometriosis to accurately measure symptoms and their course over time, allowing for personalized treatment and adequate monitoring of treatment efficacy in individual patients.

Methods

On the basis of international guidelines, items from validated questionnaires were selected through a literature review and during focus groups and multidisciplinary expert meetings. Data analysis was conducted using ATLAS.ti (ATLAS.ti Scientific Software Development GmbH). The feasibility and usability of the newly developed momentary assessment tool were tested for 28 consecutive days in 5 patients with endometriosis-related pain symptoms.

Results

Momentary assessment items contained questions concerning endometriosis symptoms, general somatic symptoms, psychological symptoms, contextual information, and the use of food and medication. A morning questionnaire on sleep and sexuality was included. In a pilot study, the patients considered the tool easy to use but time consuming. The average compliance rate of momentary assessments was 37.8% (106/280), with the highest completion rate during the first week (39/70, 56%). Therefore, it is advisable to use the ESM for a maximum of 7 days.

Conclusions

A new digital tool for endometriosis symptom assessment was developed using the ESM, which may help overcome the limitations of current retrospective questionnaires. After validation and testing, future studies will be planned to evaluate the use of this tool in a clinical setting in order to propose a personalized treatment plan for women with endometriosis.
Role of Telemedicine in Inflammatory Bowel Disease: Systematic Review and Meta-analysis of Randomized Controlled Trials
Authors: Pang Lanlan , Liu Hengyu , Liu Zhidong , Tan Jinyu , Zhou Long-yuan , Qiu Yun , Lin Xiaoqing , He Jinshen , Li Xuehua , Lin Sinan , Ghosh Subrata , Mao Ren , Chen Minhu
Published: October 2021

Background

Telemedicine plays an important role in the management of inflammatory bowel disease (IBD), particularly during a pandemic such as COVID-19. However, the effectiveness and efficiency of telemedicine in managing IBD are unclear.

Objective

This systematic review and meta-analysis aimed to compare the impact of telemedicine with that of standard care on the management of IBD.

Methods

We systematically searched the PubMed, Cochrane Library, EMBASE, Web of Science, and Scopus databases on April 22, 2020. Randomized controlled trials comparing telemedicine with standard care in patients with IBD were included, while conference abstracts, letters, reviews, laboratory studies, and case reports were excluded. The IBD-specific quality of life (QoL), disease activity, and remission rate in patients with IBD were assessed as primary outcomes, and the number of in-person clinic visits per patient, patient satisfaction, psychological outcome, and medication adherence were assessed as secondary outcomes. Review Manage 5.3 and Stata 15.1 were used for data analysis.

Results

A total of 17 randomized controlled trials (2571 participants) were included in this meta-analysis. The telemedicine group had higher IBD-specific QoL than the standard care group (standard mean difference 0.18, 95% CI 0.01 to 0.34; P.03). The number of clinic visits per patient in the telemedicine group was significantly lower than that in the standard care group (standard mean difference −0.71, 95% CI −1.07 to −0.36; P<.001). Subgroup analysis showed that adolescents in the telemedicine group had significantly higher IBD-specific QoL than those in the standard care group (standard mean difference 0.42, 95% CI 0.15 to 0.69; I2=0; P.002), but there was no significant difference between adults in the 2 groups. There were no significant differences in disease activity, remission rate, patient satisfaction, depression, self-efficacy, generic QoL, and medication adherence outcomes between the telemedicine and standard care groups.

Conclusions

Telemedicine intervention showed a promising role in improving IBD-specific QoL among adolescents and decreased the number of clinic visits among patients with IBD. Further research is warranted to identify the group of patients with IBD who would most benefit from telemedicine.
Provocações dialogantes sobre o ensino de filosofia na educação básica
Authors: Café Anderson Luis da Paixão
Published: October 2021

Foi com o objetivo de convidar os seus leitores a adotarem um pensamento aberto, flexível, receptivo, acolhedor, flutuante e, ao mesmo tempo, capaz de reformular-se e refazer-se a cada instante que o professor e pesquisador Dante Augusto Galeffi entregou à comunidade acadêmica e não acadêmica a obra intitulada “Filosofar & Educar 2: quando filosofar é educar”, publicada pela editora CRV, no ano de 2019, contendo 180 páginas, nas quais o professor Dante trouxe uma série de textos produzidos por ele durante as suas inúmeras participações em eventos científicos e que colabora, em muito, para se entender o papel da Filosofia no ensino básico enquanto possibilidade de desenvolvimento de um pensamento extremamente livre que se contraponha a todas e a quaisquer formas de exercícios de poder e de dominação exercidos sobre mentes e corpos na sociedade contemporânea.
Educação tecnológica no ensino fundamental, anos finais, uma pesquisa-ação participativa
Authors: Almeida Iara Carnevale de , Nascimento Erinaldo , Bittencourt João Paulo , Lazaretti Maria Gabriela Costa , Sanchez Delfino Maryangela
Published: October 2021

Por exigência da atual Base Nacional Curricular Comum proposta pelo Ministério da Educação, professores das escolas públicas e privadas reveem suas práticas para atender à nova geração de nativos digitais através do ensino da tecnologia. Os docentes buscam motivar seus alunos para a inovação tecnológica ao aplicar novos métodos de ensino, tais como Lean Startup, Game Learning, Design Thinking, Lean Education Technology e Letramento Digital. Portanto, o objetivo desta pesquisa é compreender como as atuais práticas de ensino tecnológico influenciam a construção do conhecimento da geração de nativos digitais. A metodologia é de natureza aplicada com abordagem qualitativa por meio de pesquisa documental e pesquisa-ação participativa em turmas do 6o ao 9o anos de uma escola privada no estado do Paraná. O resultado desta pesquisa é o registro documental do desenvolvimento de projetos dos alunos, em que se adotaram as metodologias Lean Startup, Game Learning, Design Thinking, Lean Education Technology e Letramento Digital.
Ciudades educadoras, territorios educacionales y desarrollo profesional docente: entre prescripciones y singularidades
Authors: Cusati Iracema Campos , Santos Neide Elisa Portes dos , Carrillo Avelar Antonio
Published: October 2021

El artículo analiza la relación entre escuela, ciudad y territorio, desde perspectivas y experiencias de educación integral. El desarrollo integral considera no solo el aspecto intelectual, sino también las diferentes formas y lenguajes por los que los sujetos aprenden y construyen sus identidades, sus formas de ser y estar en el mundo, en contacto con otras personas, con el entorno y con la sociedad. En el análisis desarrollado en este artículo, la articulación con el territorio es fundamental para la educación integral en la vida escolar diaria, así como en acciones y políticas que garanticen el pleno desarrollo de la ciudadanía. En los territorios educativos, las personas construyen sus subjetividades, formas de ser y de relacionarse con los demás. A partir de una investigación bibliográfica y documental de carácter cualitativo, fue posible comprender la relación entre ciudad, escuela y territorios educativos. La elucidación del significado de territorio educativo viabiliza acciones escolares que permitan un mejor uso de los espacios en la comunidad y brinden un proceso educativo vinculado a las vivencias cotidianas de los estudiantes. Hacer de la ciudad objeto de educación significa superar los límites de superficialidad y parcialidad que a menudo puede presentar el aprendizaje que se realiza en el medio urbano.
O direito à cidade que educa e os seus territórios nas práticas docentes: desafios à formação continuada de professores
Authors: Donato Sueli Pereira , Silva Marcio Tascheto da , Santos Simone José Aparecida da Silva
Published: October 2021

Este artigo trata do direito à cidade como prerrogativa de todos, e para isto situa o papel educador, segundo uma perspectiva de aproximação entre escola e cidade por meio de intervenções político-pedagógicas e da construção de territórios educativos somados aos desafios enfrentados durante a formação continuada de professores. Sendo assim, o objetivo geral é demonstrar a relevância da efetivação, nas práticas docentes escolares, do direito à cidade que educa em prol da formação para e pela cidadania ativa. A metodologia do trabalho recorre a estudo exploratório documental e bibliográfico de abordagem qualitativa, cuja reflexão assevera que espaços urbanos constituem potenciais territórios educacionais de valiosas oportunidades de formação e de aprendizagens contextualizadas, conectadas com a vida na tessitura da cidadania ativa para assegurar o direito humano à cidade que educa. Deste modo, importa às práticas docentes escolares conceber o espaço como matriz formadora do humano e a cidade como agente, conteúdo e sujeito da educação, o que impõe desafios à formação continuada docente, visto que precisa pensar sintonizada com a retomada humana da formação da/na cidade com as pessoas, desdobramento pedagógico necessário para uma cidadania de alta intensidade no marco da cidade que educa.
Cidades Educadoras: um estado da arte entre 1990 e 2020 e a relação com a educação formal
Authors: Bacila Maria Silvia
Published: October 2021

Esta investigação discute as produções bibliográficas sobre cidades educadoras, segundo o movimento preconizado pela Associação Internacional de Cidades Educadoras (AICE), e suas relações com a educação formal, não formal e informal. Para tal, identificou-se a produção bibliográfica em livros publicados em língua portuguesa entre 1990 e 2020. A pesquisa é um estudo exploratório (TRIVIÑOS, 2006), do tipo estado da arte, pois visa mapear esta produção para responder às aproximações e aos distanciamentos com a temática educacional (ROMANOWSKI; ENS, 2006). A coleta de dados ocorreu por meio de levantamento bibliográfico e a busca das obras foi realizada em sites de e-commerce, com os descritores “cidade educadora” e “cidades educadoras”. Encontraram-se 11 obras publicadas em língua portuguesa — duas provenientes de Portugal. As obras originárias das editoras portuguesas apresentaram uma expressiva familiaridade com o movimento da AICE de Barcelona; já os outros trabalhos aludem a perspectivas formais ou não formais da educação. No entanto, um dos livros distancia-se do movimento da AICE, embora contribua com as pesquisas sobre os sujeitos e a vida na cidade. Para investigações futuras, sugere-se o levantamento de outras questões, provenientes das obras analisadas.
Pedagogias do urbanismo em intervenções urbanas
Authors: Barbieri Rodrigo Adonis , Costa Marisa Vorraber
Published: October 2021

Inscrito na perspectiva teórica dos Estudos Culturais em Educação, o artigo apresenta uma discussão acerca das possibilidades de uma dimensão pedagógica do urbanismo embasado em pesquisa que teve como objeto de estudo a proposta de revitalização do Cais Mauá de Porto Alegre/RS/BR. Nessa direção, expõe-se e debate-se o conceito de pedagogias culturais, adotado para a análise de tópicos do website da proposta, com aproximações à noção de revitalização no urbanismo. Argumenta-se acerca da produtividade da articulação entre campos distintos de saber – urbanismo e educação – para a investigação das cidades e das práticas que as constituem. Apontam-se estratégias empregadas no site para dirigir as percepções do público, ensinando o que seria desejável para melhorar a vida na cidade. Como corolário, entende-se o conceito de pedagogias do urbanismo como produtivo para se vislumbrar certa forma de conduzir a vida nas cidades.
Cidades inteligentes: entrevista com o pesquisador Fábio Duarte
Authors: Santos Simone José Aparecida da Silva
Published: October 2021

Esse depoimento do Professor Doutor Fábio Duarte à Revista Intersaberes é uma valiosa contribuição para socializar reflexões na perspectiva das cidades inteligentes.
Incidencia de la enfermedad de Fabry en pacientes con enfermedad renal crónica atendidos en tres centros de salud del departamento de Atlántico, Colombia. 2017-2018
Authors: Barros Camargo Luis , Santamaria Mancera Luis Eduardo , Quintero Marzola Ivan Dario , Gómez Alba Kevin Jair , Medina Buelvas Ana Mercedes , Ramos Villegas Yancarlos
Published: October 2021

Introducción:
La enfermedad de Fabry consiste en un defecto lisosomal caracterizado por la alteración de la enzima (alfa-galactosidasa A) lo que produce el acúmulo de glucoesfingolípidos en diferentes tejidos. Este defecto enzimático está ligado al cromosoma X y por ende es más frecuente en hombres. Las manifestaciones clínicas varían de acuerdo al grupo etario afectado e incluye frecuentemente lesiones en piel, anhidrosis, opacidades corneales, crisis de dolor, daño renal, entre otros.
Objetivos:
Calcular la incidencia de enfermedad de Fabry en pacientes con diagnóstico de enfermedad renal Crónica
Metodología:
Se diseñó un estudio ambispectivo, cuya población de estudio abarcó a los pacientes con diagnóstico de Enfermedad Renal crónica, que asistían a controles médicos en tres centros de prevención renal ubicados en el departamento del Atlántico, y que además cumplían los criterios de inclusión y exclusión. Posteriormente se realizó la revisión de las historias clínicas y la toma de muestras.
Resultados:
Se identificaron un total de 471 pacientes con enfermedad renal crónica, con una incidencia global de 21,23 casos por cada 1000 personas, cuya actividad de la alfa galactosidasa se encontró baja. Sin embargo, solo el 20% fueron confirmadas mediante pruebas genéticas.
Conclusiones:
La incidencia de la enfermedad de Fabry en la población estudiada es mayor a la reportada en otras cohortes y fue más frecuente en el sexo femenino.
Edulcorantes artificiales y su papel en la enfermedad renal crónica
Authors: Bohórquez Rivero José , Saenz Lopez Jose David , Restom-Arrieta José Gabriel , Tatis Villamizar Keyner Enrique , Sánchez Martínez Diego , Brieva Deulofeut Mónica , Montenegro Gómez Angélica Patricia , Abuabara-Franco Emilio
Published: October 2021

Los edulcorantes artificiales no calóricos han surgido para ofrecer una opción segura y saludable en el marco de la alimentación. Han abarcado especial atención en las ultimas décadas, precisamente por la cultura de alimentación adquirida en la actualidad, donde ha tomado especial fuerza la alimentación con la comida rápida y el alto consumo de azúcar, lo que repercute negativamente en la incidencia de enfermedades metabólicas. En ese orden de ideas los edulcorantes artificiales no calóricos, proponen una mejor salud sin la necesidad de un cambio drástico en el estilo de vida. Empero, sus beneficios no han sido estudiados a profundidad, además de que no ha habido un cambio significativo en el desarrollo de enfermedades metabólicas asociadas al consumo de azúcar, por el contrario, se han relacionado con enfermedades como la obesidad, diabetes mellitus tipo 2 y síndrome metabólico. Así mismo, provocan una serie de cambios metabólicos por distintos mecanismos que terminan en proteinuria progresiva y el descenso de la tasa de filtrado glomerular. En orden con lo anterior, se hace necesario un análisis del riesgo al que se está sometido al elegir esta opción alimenticia, y no dejarse ensordecer ni mucho menos deslumbrar por los procesos mediáticos, si no mas bien, regirse por los hallazgos científicos.
Estimation of the efficiency of measures of correction of the functional state of the cardiovascular system of operators of deep water technical means during the course of the voyage
Authors: Khankevich Yu. R. , Sapozhnikov K. V. , Cherkashin D. V. , Kutelev G. G. , Parfenov S. A. , Paulov A. A.
Published: October 2021

During the course of the voyage, divers experience the effect of the wide range of adverse factors of operator labor and ship's habitability.

The objective of the study is to estimate the state of cardiovascular system of operators of deep water technical means after using the complex of measures aimed at correction of function al state of operators during the course of the voyage.

Materials and methods. The study was conducted with the participation of 38 operators of deep water technical means from among the crew of nuclear submarine engaged in operator labor activity. The study was performed twice: before the voyage and after return to base and included: cardiorhythmogram and psychophysiological study methodologies of functional state. Patients were divided into two groups: main (n = 13) and control (n = 25).

Results and discussion. The control group shows sympathicotonia (reducing heart rate variability, intensity of respiratory arrhythmia). The main group, on the contrary, shows relative balance of regulatory systems. Thus, the conducted assessment of the state of cardiovascular system showed positive effects of using the complex of measures aimed at correction of functional state of operators during the course of the voyage.
А case of heparin-induced thrombocytopenia in a patient with a novel coronaviral infection, features of diagnosis and treatment in a naval hospital conditions
Authors: Shapovalov I. D. , Makarchenko V. E. , Kartina O. Yu. , Belousova T. L.
Published: October 2021

The heparin-induced thrombocytopenia is a severe, potentially life-threatening complication of heparinotherpapia associated with thrombosis, develops as a result of antibody-mediated platelet activation. In the context of the SARS CoV-2 pandemic, the frequency of use of heparin in clinical practice has significantly increased, as a result of which the doctors have become more likely to face this complication. The article presents a review of the literature, describes the pathogenesis, modern algorithms for diagnosis and treatment, demonstrates a clinical case of heparin-induced thrombocytopenia in a patient with the SARS CoV-2, and discusses the features of diagnosis and treatment of this complication in a naval hospital.
Geoecological Characteristics and Comprehensive Assessment of the Effectiveness of Urban Improvement Management in a Large Siberian City
Authors: Koroleva E. N.
Published: October 2021

Introduction. The issues of creating, preserving and improving the quality of green areas are relevant not only for the municipality — the city of Barnaul, but also for each urban settlement of the Russian Federation, village and settlement.

Methodology. To identify numerous shortcomings in the management, a statistical analysis of the main indicators of the development of the improvement sector, the main opinions of «experts», was carried out. In order to find ways out to ensure the comfort of living for each resident of the city, a theoretical generalization is used.

Results. The main geoecological characteristics of the municipality — the city of Barnaul – are described. It reflects not only the achievements of local governments in this area, but also highlights the main problem-the lack of a unified concept of landscaping. To predict the development of the city and the formation of a unified approach to landscaping, the main measures are proposed that will allow creating an up-to-date, and most importantly, allowing each resident to comfortably exist, a model for managing the field of landscaping.

Analysis and discussion. The forecast estimate for the municipality — the city of Barnaul from the proposed measures for rational use of natural resources is given.

Conclusions. The application of these results is not only possible, but it is also necessary to take into account the local self-government bodies when managing the geoecological processes of each city of the Russian Federation in order to achieve an optimal standard of living for the population.
The Evolution of Economic Research Strategies: The Role of the Concept of Strategizing V. L. Kvint
Authors: Alаbinа T. A.
Published: October 2021

The two-part series of articles reveals the purpose of the research as determining the place of the concept of strategizing of a Foreign Member of the Russian Academy of Sciences – Academician, Doctor of Economics, Professor V. L. Kvint in the system of economic research of strategies abroad, in the USSR and modern Russia on the basis of the description of the content and systematization of the basic concepts of strategizing and a review of foreign and domestic regional economic research, as well as the author’s identification of the key characteristics of this scientific school of strategy.

The object of the research is the theory of strategies abroad, in the USSR and modern Russia. The subject of the research is the concept of V. L. Kvint’s strategizing in the system of economic research on strategy.

The methodological tools include techniques and methods of system analysis, comparative analysis, logical analysis, principles of the dialectical-materialistic method of cognition and an integrated approach to the characterization of economic research, methods of generalization and concretization. The description of the study uses a historical approach and a temporary generalization based on the key milestones in the development of economic research on the theory of strategy and the methodology and practice of strategizing.

As the results of present article, the main characteristics, systematization and content aspects of foreign and domestic economic research strategies are presented. The place of V. L. Kvint’s concept of strategizing in the system of economic research are determined. The article shows the practice of strategizing the research school.
Russia at the Turn of the World Economy
Authors: Matreshina D. E. , Maryshev A. A.
Published: October 2021

The purpose of this study is to determine and substantiate the importance of deepening cooperation between the Russian Federation and the countries of the Asian region in modern conditions. The work emphasizes and substantiates the importance of the development of integration processes in the formation of a strategy for international cooperation of states in the context of global socio-economic and political restructuring. The general world tendencies influencing the Russian economy in the conditions of a gradual transition to a new world economic order are given. The article examines the policy pursued by the state that can influence its place within the framework of the new integral world economic order. The paper describes the transformation and structure of relations between the member states of the Eurasian Economic Union (EAEU) with the countries of the Shanghai Cooperation Organization (SCO) and the Association of Southeast Asian Nations (ASEAN) in the context of the emerging concept of the Greater Eurasian Partnership and the change in the world economic order.

When preparing the work, first of all, we used a logical, factorial, statistical analysis, synthesis, a systematic approach.

The scientific novelty of the work consists in defining and describing Russia’s potential within the framework of the transition to a new world economic order, taking into account a combination of factors, namely: its position in the Eurasian Economic Union, the implementation of the Strategic Directions for the Development of Eurasian Economic Integration until 2025, the development of cooperation with the SCO and ASEAN states, as well as conjugation of the EAEU and the One Belt, One Road project.
Global Changes in Higher Education: Post-Covid Times
Authors: Bayer J. P. , Churaev N. A.
Published: October 2021

In this article we talk about education as a global phenomenon that includes many actors with their own political interests. In this regard, the question of the anthropological component of modern education, including in the international context, arises extremely sharply: what kind of person is formed by the new global education, to whom it applies, and what values it forms. Main trends in global education policy are defined. The formation of a global educational policy has not yet been completed, and the pandemic of coronavirus infection has brought both positive and negative aspects. We name both of them: the advantages and disadvantages of pandemic situation that shifted the global higher education into the different format. Also, we make the forecast on further higher education development.
Higher Education. How to See 2027 from 2021?
Authors: Shamakhov V. A.
Published: October 2021

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A PATH GUIDED METHOD FOR QUICKLY LABELING ROADS IN SATELLITE IMAGES
Authors: ÖZCAN Samet Cengiz , BÜLBÜL Muhammed Abdullah
Published: October 2021

Determining roads from satellite images has gained more research interest after the recent progress on data-heavy machine learning methods which are also accelerated by the increased amounts of accessible data. An important challenge of learning-based approaches is obtaining labeled data to train the systems. In this study, we propose a method for quickly labeling roads over satellite images of any desired location. Our method exploits the 2D path information obtained from OpenStreetMap, an online community-contributed source of geolocated information. In this environment, roads are roughly described as line segments without their exact shapes and sizes. Using this rough information, we propose a simple interactive user interface where users easily label the road boundaries over presented satellite images. Using our approach, it is possible to rapidly label regions with different road characteristics. Such an approach allows for training separate machine learning systems for different parts of the world which would be advantageous over training a single system to identify all kinds of roads.
ArVirInd - a database of arboviral antigenic proteins from the Indian subcontinent
Authors: Atre Nitin , Alagarasu Kalichamy , Shil Pratip
Published: October 2021

Studies on antigenic proteins for arboviruses are important for
providing diagnostics and vaccine development. India and its
neighbouring countries have huge burden of arboviral diseases. Data
mining for country-specific sequences from existing databases is
cumbersome and time-consuming. This necessitated the development of a
database of antigenic proteins from arbo-viruses isolated from the
countries of the Indian subcontinent. Arboviral antigenic protein
sequences were obtained from the NCBI and other databases. In silico
antigenic characterization was performed (Epitope predictions) and data
incorporated in the database. The front end is designed and developed
using HTML, CSS and PHP. For the backend of the database, we have used
MySQL. A database, named ArVirInd, is created as a repository of
information on antigenic proteins. This enlists sequences by country and
year of outbreak or origin of the viral strain. For each entry antigenic
information is provided along with functional sites, etc. Researchers
can search this database by virus/protein name, country and year of
collection (or in combination). It is available publicly via Internet at
http://www.arvirind.co.in. ArVirInd will be useful in the study of
immuno-informatics, diagnostics and vaccinology for arboviruses.
Global identification of full-length cassava lncRNAs unveils the role of CRIR1 in cold stress response
Authors: li shuxia , Cheng Zhihao , Dong Shiman , Li Zhibo , Zou Liangping , Zhao Pingjuan , Guo Xin , Bao Yan , Wang Wenquan , Peng Ming
Published: October 2021

Long non-coding RNAs (lncRNAs) have been considered to be important
regulators of gene expression in a range of biological processes in
plants. A large number of lncRNAs have been identified in plants.
However, most of their biological functions still remain to be
determined. Here, we identified total 3 004 lncRNAs in cassava under
normal or cold-treated conditions from Iso-seq data. We further
characterized a lincRNA, CRIR1, as a novel positive regulator of the
plant response to cold stress. CRIR1 can be significantly induced by
cold treatment. Overexpression of CRIR1 in cassava enhanced the cold
tolerance of transgenic plants. Transcriptome analysis demonstrated that
CRIR1 regulates a range of cold stress-related genes in a
CBF-independent pathway. We further found that CRIR1 RNA can interact
with MeCSP5, a homolog of the cold shock protein that acts as RNA
chaperones, indicating that CRIR1 may recruit MeCSP5 to improve the
translation efficiency of mRNA. In summary, our study greatly extends
the repertoire of lncRNAs in plants as well as its responding to cold
stress. Moreover, it reveals a sophisticated mechanism by which CRIR1
regulates plant cold stress response by modulating the expression of
stress-responsive genes and increasing the translational yield.
Whole genome resequencing reveals signatures of rapid selection in a virus affected commercial fishery
Authors: Holland Owen , Toomey Madeline , Ahrens Collin , Hoffmann Ary , Kroft Larry , Sherman Craig , Miller Adam
Published: October 2021

Infectious diseases are recognised as one of the greatest global threats
to biodiversity and ecosystem functioning. Consequently, there is a
growing urgency to understand the speed at which adaptive phenotypes can
evolve and spread in natural populations to inform future management.
Here we provide evidence of rapid genomic changes in wild Australian
blacklip abalone (Haliotis rubra) following a major population crash
associated with an infectious disease. A genome wide association study
on H. rubra was conducted using pooled whole genome re-sequencing data
from commercial fishing stocks varying in historical exposure to
haliotid herpesvirus-1 (HaHV-1). Approximately 25,000 SNP loci
associated with virus exposure were identified, many of which mapped to
genes known to contribute to HaHV-1 immunity in the New Zealand pāua (H.
iris) and herpesvirus response pathways in haliotids and other animal
systems. These findings indicate genetic changes across a single
generation in H. rubra fishing stocks decimated by HaHV-1, with stock
recovery determined by rapid evolutionary changes leading to virus
resistance. This is a novel example of rapid adaptation in natural
populations of a non-model marine organism, highlighting the pace at
which selection can potentially act to counter disease in wildlife
communities.
Advancing Remote Sensing and Machine Learning-Driven Frameworks for Groundwater Withdrawal Estimation in Arizona: Linking Land Subsidence to Groundwater Withdrawals
Authors: Majumdar Sayantan , Smith Ryan , Conway Brian , Lakshmi V
Published: October 2021

Groundwater plays a crucial role in sustaining global food security but
is being over-exploited in many basins of the world. Despite its
importance and finite availability, local-scale monitoring of
groundwater withdrawals required for sustainable water management
practices is not carried out in most countries, including the United
States. In this study, we combine publicly available datasets into a
machine learning framework for estimating groundwater withdrawals over
the state of Arizona. Here we include evapotranspiration, precipitation,
crop coefficients, land use, well density, and watershed stress metrics
for our predictions. We employ random forests to predict groundwater
withdrawals from 2002-2020 at a 2 km spatial resolution using in-situ
groundwater withdrawal data available for Arizona Active Management
Areas (AMA) and Irrigation Non-Expansion Areas (INA) from 2002-2009 for
training and 2010-2020 for validating the model respectively. The
results show high training (R≈ 0.86) and good testing
(R≈ 0.69) scores with normalized mean absolute error
(NMAE) ≈ 0.64 and normalized root mean square error (NRMSE) ≈ 2.36 for
the AMA/INA region. Using this method, we spatially extrapolate the
existing groundwater withdrawal estimates to the entire state and
observe the co-occurrence of both groundwater withdrawals and land
subsidence in South-Central and Southern Arizona. Our model predicts
groundwater withdrawals in regions where production wells are present on
agricultural lands and subsidence is observed from Interferometric
Synthetic Aperture Radar (InSAR), but withdrawals are not monitored. By
performing a comparative analysis over these regions using the predicted
groundwater withdrawals and InSAR-based land subsidence estimates, we
observe a varying degree of subsidence for similar volumes of
withdrawals in different basins. The performance of our model on
validation datasets and its favorable comparison with independent water
use proxies such as InSAR demonstrate the effectiveness and
extensibility of our combined remote sensing and machine learning-based
approach.
Estimation of subsurface flow from high-resolution temperature profiles
Authors: Zhang Bo , Gu Kai , Bayer Peter , Shi Bin , Xiang Fulin , Wei Zhuang , Wang Baojun
Published: October 2021

Subsurface flow rates are critical for hydrology and geothermal
research, while field characterization remains a challenge. There are
several analytical solutions for calculating the vertical water flux
based on measured temperatures. Heat is a popular natural tracer to
estimate subsurface flow rates. However, quantifying flow rates is
impeded by insufficient sensors spacing during field investigations or
simplifying assumptions for analysis such as sinusoidal temperature
boundary. The objective of this study is to develop a convenient method
to investigate subsurface flow on the sub-meter scale. Here, we present
a program to estimate water fluxes based on temperature-depth profiles,
so-called TempFlow. TempFlow is a numerical program written in MATLAB
that calculates steady state flow in transient heat tracing based on the
inversion of measured high-resolution temperature-depth series observed
at a certain time. In this program, the Fiber Optic Distributed
Temperature Sensing (FO-DTS) is recommended for temperature collection.
FO-DTS techniques provide high-resolution temperature measurements with
continuous temperature profiles that account for sub-meter scale and
nonperiodic boundary conditions in saturated sediments. The estimated
subsurface flow using TempFlow was validated in a medium-scale tank with
a series of experiments, where the hydraulic and temperature boundary
conditions were well-controlled. The results indicate that the
estimation using TempFlow obtained similar results as the experiments.
Thus, the method could potentially be used to determine the flow rate of
the subsurface.
A coupled dynamic leakage loss and flood routing model for ephemeral rivers with complex sections
Authors: Liu Congmin , Pan Chengzhong , Liu Chunlei , Zhai Yuanzheng , Xue Wanlai
Published: October 2021

Ephemeral rivers commonly occur in regions with a shortage of water
resources, and their channel configuration tends to change substantially
owing to cultivation, tree planting and sand extraction. There is an
urgent need to restore degraded river ecosystems. During short-term
water conveyance, water storage in sand pits and leakage in dry
riverbeds retards the flow of water, which is detrimental for ecological
restoration of the riparian zone. A coupled dynamic leakage loss and
flood routing model was established to predict the flow processes in the
complex river channel of the Yongding River in China. The model mainly
included three sub-models of flow dynamics, dynamic leakage loss, and
water balance along multiple cross sections of the river channel. The
complex section is reflected in the different infiltration properties
for each section, and the existence of sand pits. The water head was
dominated by flow velocity and the overflow from sand pits. Owing to the
difference in landforms and the deposited sediment size of the riverbed
bottom, the river channel was divided into 11 cross sections and a sand
pit to ascertain the respective infiltration or leakage loss processes.
The input parameters of the model came from field surveys of sand pits,
river geometry and hydrogeology. The model was also calibrated and
validated using monitoring data from ecological water releases into the
Yongding River in 2019 and 2020. This coupled model can predict the
water leakage loss and flow process of the water head and also provide
important guidance for river reconstruction and ecological restoration.
Ground-nesting by arboreal American robins (Turdus migratorius)
Authors: Winnicki Sarah , Hauber Mark , Benson Thomas , Abolins-Abols Mikus
Published: October 2021

Animals with dependent and vulnerable young need to decide where to
raise their offspring to minimize ill effects of weather, competition,
parasitism, and predation. These decisions have critical fitness
consequences through impacting the survival of both adults and
juveniles. Birds routinely place their nest in specific sites, allowing
species to be broadly classified based on nest location (e.g., ground-
or tree-nesting). However, from 2018–2020 we observed 24 American robin
(Turdus migratorius) nests placed not on their species-typical arboreal
substrates or human-made structures but on the ground at a predator-rich
commercial arbor in Illinois, U.S.A. This behavior does not appear to be
in response to competition and did not affect nest daily survival rate
but was restricted to the early half of the breeding season. We
hypothesize that ground-nesting may be an adaptive response to avoid
exposure and colder temperatures at sites above the ground early in the
breeding season or a non-adaptive consequence of latent robin
nest-placement flexibility.
Biological and physiological properties of reverse ankyrin engineered for dimer construction to enhance HIV-1 capsid interaction
Authors: Juntit On-anong , Yasamut Umpa , Sakkhachornphop Supachai , Chupradit Koollawat , Thongkum Weeraya , Wisitponchai Tanchanok , Prangkio Panchika , Srisawat Chatchawan , Lee Vannajan , Chokepaichitkool Tawan , Kongtawelert Prachya , Nimmanpipug Piyarat , Tayapiwatana Chatchai
Published: October 2021

Assembly and budding in the late-stage of human immunodeficiency virus
type 1 (HIV-1) production relies on the polymerization of Gag protein at
the inner leaflet of the plasma membrane. We previously generated an
ankyrin repeat protein (Ank1D4) that specifically interacts with the
CAp24 protein. This study aimed to improve the binding activity of
Ank1D4 by generating two platforms for the Ank1D4 dimer. The design of
these constructs featured a distinct orientation of monomeric Ank1D4
connected by a linker peptide (G S) .
The binding surfaces in either dimer generated from the C-terminus of
the Ank1D4 monomer linked with the N-terminus of another monomer (Ank1D4
) or its inverted form (Ank1D4
), similar to monomeric Ank1D4. The interaction of
Ank1D4 with CAp24 from capture ELISA was
significantly greater than that of Ank1D4 and the
parental Ank1D4. The bifunctional characteristic of Ank1D4
was further demonstrated using sandwich ELISA. The
binding kinetics of these ankyrins were evaluated using bio-layer
interferometry analysis. The K of Ank1D4
, Ank1D4 and monomeric Ank1D4
was 3.5 nM, 53.7 nM, and 126.2 nM, respectively. The dynamics of the
interdomain linker and the behavior of ankyrin dimers were investigated
in silico. Upon the binding distance calculation from the
candidate structures, the achievement in obtaining double active sites
is more possible in Ank1D4 . The CD spectroscopic
data indicated that secondary structure of dimer forms resemble Ank1D4
monomer α-helical content. This finding confers the strategy to generate
dimer from rigid scaffold for acquiring the binding avidity.
Program improving autonomy and scientific research in remote education
Authors: Venegas-Claros Juana , Gonzales-Sánchez Aracelli , Alex-Valenzuela Luis , Visurraga-Agüero Joel , Luy-Montejo Carlos Augusto
Published: October 2021

Students in Regular Basic Education have shown some difficulties in developing autonomy during their learning sessions; however, this situation increased when remote education was implemented, due to mandatory confinement, caused by the emergence of Covid 19, an alternative had to be sought, which allowed solutions to this situation to be provided. It was formulated as a study objective was to implement a Program improving autonomy and scientific research in remote education. The method used was a quantitative approach, with experimental design, a population of 84 students from the I.E. Celso Lino Ricaldi was used, a program was applied in ten sessions, resulting after its implementation, in the post test that 35.71% of the control group and 67.86% of the experimental group are at the level achieved. This data led to the conclusion that the programme implemented has positive effects on the autonomous learning and scientific research of the chosen educational institution.
Directions of formation of humanistic values in higher education institutions: problems and perspectives
Authors: Jabbarli Matanat
Published: October 2021

The article analyzes the directions of the formation of humanistic values in higher education institutions. The results of the study showed that students have a high attitude to humanistic values, regardless of the level of self-affirmation and self-esteem. The main mechanisms of formation of humanistic values in students depend on the provocative features of social values, which occupy a dominant place in the hierarchy of values and professional self-confidence, which reflects the integrated qualities of the individual. It was found that there is a positive correlation between humanistic qualities and personal qualities and academic achievements. There is an important connection between self-awareness, self-esteem, self-assertion, and a social ideal that reflects humanistic qualities in students. It can be concluded that in order to develop humanistic values, it is necessary to develop socially important values and personality traits. Here it is necessary to consider the cognitive needs, opportunities for self-affirmation, as well as learning achievements.
The use of digital technologies in the professional training of bachelors of arts in the context of distance learning
Authors: Barytska Oleksandra , Gavran Iryna , Hutsal Rosina , Turovska Natalia , Tsaruk Svitlana
Published: October 2021

In the context of a pandemic and the introduction of quarantine measures, the issue of proper organization of the educational process without interfering with the curriculum becomes especially relevant. Distance learning is a way to solve this problem, but for this type of learning to be effective, it is necessary to understand what digital technologies will help to master the educational program. Therefore, the purpose of the study was to identify which of the modern digital technologies are the most effective for distance learning and based on the analysis to develop a model of online training for Bachelor of Arts. The study applied an analysis, which helped to evaluate modern digital technologies in terms of efficiency for use in distance learning, and modelling, which helped to create an optimal learning model in terms of distance learning.
Introduction of innovative technologies in the study of music disciplines in higher educational institutions of Ukraine
Authors: Karas Hanna , Romaniuk Lesia , Novosiadla Iryna , Obukh Liudmyla , Zvarychuk Zhanna
Published: October 2021

The problem of modernization of the modern educational system in Ukraine, updating the content and organizational forms of teaching and education, techniques and methods of pedagogical work in higher education encourages the search for new methods and tools of teaching and learning, introduction of innovative technologies, including information and communication. The study considers the application of multimedia technologies, interactive learning and coaching technologies in the study of music-theoretical and music-historical disciplines ("Music Theory", "Solfeggio", "Harmony", "Polyphony", "Analysis of Musical Works", "History of World Music" and "History of Ukrainian Music"), which constitute the fundamental basis of musical training of future professionals, the development of their musicological competencies of various types and content, as well as in mastering the disciplines ("Piano as the Major Instrument", "Choral Conducting", "Choral Class"), which develop special competencies.
Pengaruh Beban Kerja terhadap Kepuasaan Karyawan di Hotel Grand Zuri Padang
Authors: Monica Shinta , Asnur Lise
Published: October 2021

Penelitian ini dilatarbelakngi oleh berbagai permasalahan diantaranya: tidak adanya promosi jabatan untuk karyawan, terjadinya konflik antara sesama rekan kerja, karyawan yang merasa terbebani oleh waktu mengerjakan tugas yang diberikan oleh atasan, dan karyawan yang komplain mengenai jam istirahat yang tidak sesuai dengan yang diharapkan menyebabkan kurangnya kepuasaan karywan dalam bekerja. Penelitian ini bertujuan untuk melihat pengaruh beban kerja  terhadap kepuasan kerja karyawan di Hotel Grand Zuri Padang. Jenis penelitian ini adalah penelitian deskriptif kuantitatif dengan pendekatan asosiatif kausal. Data yang digunakan data primer yaitu jumlah karyawan. Sampel yang digunakan adalah sampel jenuh dimana seluruh karyawan yang ada di Hotel Grand Zuri Padang. Pengumpulan data dilakukan dengan menyebar angket dengan memakai metode skala likert. Analisis data yang digunakan dalam penelitian ini adalah analisis regresi linier berganda. Hasil penelitian ini menunjukkan bahwa beban kerja berada pada kategori baik (59,72%) kepuasan kerja berada pada kategori baik (52,78%) didapatkan nilai F 28,083, nilai t 5.299 dan nilai R square 0,286.Kata Kunci : Beban Kerja, Kepuasan Kerja
Tingkat Pengetahuan Kesehatan Pribadi di Masa Covid 19 pada Remaja
Authors: Antara Kadek Yogi
Published: October 2021

Dewasa ini, dunia sedang diguncang oleh pandemik hebat bernama Covid-19 (Corona Virus Disease). Peningkatan dari hari kehari jumlah pasien terinfeksi virus Covid-19 sudah sulit dikendalikan diperlukannya suatu perencanaan yang jelas dan lugas dari pemerintah untuk menangulangi permasalahan ini. Penelitian ini bertujuan untuk mengetahui tingkat pengetahuan remaja pada Desa Banjar Tengah Kecamatan Negara Kabupaten tentang kesehatan pribadi dimasa Covid19. Penelitian ini merupakan penelitian deskriptif dengan satu variabel bebas, yaitu pengetahuan tentang kesehatan pribadi. Populasi adalah remaja Desa Banjar Tengah Kecamatan Negara Kabupaten Jembrana  berjumlah  100 orang remaja. Instrumen penelitian dalam bentuk teknik tes tertulis dengan model tes obyektif dan hasilnya berupa skor. Pengujian instrumen model contruct validity, dengan instrument yang sudah mendapatkan pengujian dari ahli (judgment experts). Analisis data yang digunakan dalam penelitian ini menggunakan teknik analisis deskriptif kuantitatif dengan persentase. Didapatkan kesimpulan bahwa tingkat pengetahuan kesehatan pribadi dimasa Covid19 pada remaja Desa Banjar Tengah Kecamatan Negara Kabupaten Jembrana dengan jumlah populasi 100 orang remaja, adalah untuk 18 remaja kategori tinggi atau sebesar 18%; 62 remaja kategori sedang atau sebesar 62%; dan 20 remaja kategori rendah atau sebesar 20%. Adapun saran untuk penelitian ini adalah sebaiknya peningkatan tentang pengetahuan kesehatan pribadi tidak hanya melibatkan remaja, tetapi semua masyarakat dengan menggunakan sampel yang lebih banyak sehingga diharapkan hasil penelitian yang di dapat akan lebih maksimal hasilnyaKata Kunci: Pengetahuan, Kesehatan Pribadi, Remaja Desa Banjar Tengah