bluuebunny/crossref_metadata_2025 huggingface dataset:
Equalização da disputa ou reprodução de desigualdades? Uso do Facebook por candidatas à Câmara Federal por São Paulo em 2018
Authors: Barbieri Catarina Helena Cortada , Ramos Luciana de Oliveira , Mardegan Ivan Osmo , Marin Juliana Fabbron Marin , Youssef Lais Menegon
Published: October 2021

Resumo Neste artigo, analisamos o uso de ferramentas do Facebook em campanhas eleitorais de candidatas ao cargo de deputado federal por São Paulo com o objetivo de avaliar se esse uso mitiga ou reproduz desigualdades socioeconômicas estruturais que elas vivenciam em sociedade. Acompanhamos o uso do Facebook durante a campanha eleitoral de 2018 visando entender especificamente se e como essa rede social foi utilizada por essas candidatas. A partir de uma base de dados com mais de 55 mil postagens de 465 candidatas, incorporamos um olhar interseccional sobre as múltiplas identidades dessas mulheres e correlacionamos seus marcadores sociais (estrato sócio-ocupacional, grau de instrução, idade e raça/cor) com o uso do Facebook durante a campanha eleitoral. Os resultados das análises quantitativas apontam que, em vez de mitigar as desigualdades socioeconômicas preexistentes, essa rede social acabou por reproduzi-las ao longo da campanha.
Los memes políticos como recurso persuasivo online . Análisis de su repercusión durante los debates electorales de 2019 en España
Authors: Medina Rocio Zamora , García Salvador Gómez , Martínez Helena Martínez
Published: October 2021

Resumo En el contexto del politainment online , el recurso de los memes políticos como fórmula humorística y creativa para configurar la imagen política se ha convertido en una práctica cada vez más habitual en las campañas electorales. Especialmente con motivo de la celebración de debates electorales, la difusión de memes políticos en redes sociales ha acaparado el interés de los académicos. Este artículo toma en consideración las taxonomías establecidas sobre los tipos de memes políticos y analiza su capacidad persuasiva. En concreto, la investigación incluye un análisis cuantitativo de los principales memes difundidos en Twitter durante los dos debates electorales que tuvieron lugar en la campaña electoral de 2019 en España: 4N y 7N. El estudio está fundamentado en la perspectiva del framing integrado (textual-visual) y se sustenta sobre el estudio del poder persuasivo de los memes basado en la importancia de cada uno de los elementos de la retórica ( pathos, ethos y logos ) con el objetivo de analizar, asimismo, las consecuencias sobre su viralidad y repercusión en la audiencia social.
Microbial fertilizer from PK rocks on lettuce nutrients and soil attributes in consecutive crops
Authors: Oliveira Wagner da Silva , Stamford Newton Pereira , Silva Emmanuella Vila Nova da , Arnaud Thatiana Stamford , Izquierdo Carlos Garcia , Hernández Teresa
Published: October 2021

Abstract: The objective of this work was to evaluate the effect of a microbial fertilizer, produced from phosphate and potassic rocks and earthworm compost, as an alternative to conventional fertilizers, on lettuce (Lactuca sativa) nutrients and soil attributes. The experiment was conducted in consecutive cycles (30 and 60 days) in a soil from the Lorca region, in the municipality of Murcia, Spain. The fertilization treatments were: conventional fertilizer, 100% of the recommended rate (RR); microbial fertilizer, 50% of the RR (5 Mg ha-1); microbial fertilizer, 100% of the RR (10 Mg ha-1); microbial fertilizer, 150% of the RR (15 Mg ha-1); and control, without N-P2O5-K2O fertilization. The microbial fertilizers applied at 100 and 150% of the RR showed significant and positive effects, as well as the best results for plant characteristics. The microbial fertilizer increased total N and available P and K compared with the conventional fertilizer. A residual effect was observed in the successive cycle. The effectiveness of the microbial fertilizer shows it is a viable alternative to conventional fertilizers, with positive effects on plant productivity and soil attributes.
Silicate rocks as an alternative potassium fertilizer for upland rice and common bean crops
Authors: Soratto Rogério Peres , Crusciol Carlos Alexandre Costa , Campos Murilo de , Costa Claudio Hideo Martins da , Gilabel Amanda Prado , Castro Gustavo Spadotti Amaral , Ferrari Neto Jayme
Published: October 2021

Abstract: The objective of this work was to evaluate the efficiency of molten and ground alkaline potassium-silicate rocks (K1) and of ground phonolite rock (K2) as sources of potassium for upland rice (Oryza sativa) and common bean (Phaseolus vulgaris) crops, in comparison with the traditional source (KCl). Two experiments - one with each crop - were conducted on a Typic Haplorthox in a randomized complete block design with four replicates. The treatments consisted of three sources (KCl, K1, and K2) and four rates (0, 20, 40, and 80 kg ha-1 K2O) of K. Regardless of the used source, K fertilization increased the leaf K content and grain yield of the upland rice and common bean crops. The agronomic efficiency index (AEI) of the alternative K sources varied according to the crop. For upland rice, the AEI of K2 was 8% higher than that of KCl at the recommended K rate, but similar at the highest rate. For common bean, the AEI values of K1 were close to that of KCl at the rates of 40 and 80 kg ha-1 K2O. The alternative sources K1 and K2 supply K and increase the grain yield of common bean and upland rice, respectively, similarly to KCl.
Physicochemical and aromatic composition of 'Sauvignon Blanc' wines obtained from the Y-trellis and VSP training systems
Authors: Marcon Filho José Luiz , Wurz Douglas André , Brighenti Alberto Fontanella , Kretzschmar Aike Anneliese , Rufato Leo , Caliari Vinicius
Published: October 2021

Abstract: The objective of this work was to compare the effect of the Y-trellis and vertical shoot position trellis (VSP) training systems on the physicochemical composition and aromatic profile of 'Sauvignon Blanc' (Vitis vinifera) wines in a high-altitude region of the state of Santa Catarina, Southern Brazil. The experiment was conducted during the 2015 vintage in a commercial vineyard located in the municipality of São Joaquim. The treatments consisted of the training systems: Y-trellis and VSP pruned in spur cordon. Sixty kilograms of grapes were harvested from each training system to make the wines, which were evaluated as to their chemical and phenolic composition and aromatic profile. There is no effect of the training system on the wine chemical variables pH, total acidity, color, and total polyphenols. The aromatic profile and phenolic composition of the wines are affected by the training systems, being related to the variables ethyl acetate, isoamyl acetate, 3-methyl-1-butanol, propanoic acid, and gallic acid in the Y-trellis, and to 1-hexanol, isovaleric acid, caprylic acid, capric acid, and catechin in VSP. The Y-trellis system can be an alternative for high-altitude regions of Southern Brazil.
Sugarcane harvest time for processing and technological quality of brown sugar
Authors: Tischler André Luís , Jeronimo Elisangela Marques , Lúcio Alessandro Dal’Col , Sari Bruno Giacomini , Melo Patrícia Jesus de , Boesso Francine Fricher , Diel Maria Inês , Tartaglia Francieli de Lima
Published: October 2021

Abstract: The objective of this work was to evaluate the optimal harvest time of ten genotypes of sugarcane (Saccharum officinarum) for the processing and quality of brown sugar. The experiment was carried out in a randomized complete block design in a 3x10 factorial arrangement in split plots, with three harvest times and ten sugarcane genotypes, in the state of São Paulo, Brazil. The qualitative parameters of brown sugar were evaluated by Scott-Knott’s test, at 5% probability. The harvest season in September, known as the middle of the harvest, is the most suitable for the production of brown sugar due to the higher of ºBrix values of cane, ºBrix of the broth, pol of brown sugar, and total reducing sugars in this period. The harvesting of the sugarcane genotypes in June-July is the most favorable for the production of brown sugar for the color characteristics a*, b*, L*, and chroma; however, it is also the period of production of brown sugar with a lower sugar content. The third harvest season (November) is the least recommended for brown sugar production due to the higher fiber and purity values. The most suitable genotype for brown sugar production and quality is 'IACSP04-704'.
De la desterritorialización a la reterritorialización en el acceso, uso y regulación de recursos socio-ambientales: caso de las provincias de Almeidas y sabana centro (Cundinamarca, Colombia)
Authors: Pérez Martínez Manuel Enrique
Published: October 2021

Objetivo: Interpretar las proyecciones de agentes sociales, que desde la escala local, plantean la necesidad de constituir pactos territoriales que contrarresten los conflictos por el acceso, uso y regulación de recursos socio-ambientales. Metodología: Se aplicó un ejercicio de georreferenciación de cuencas y explotaciones mineras en la zona de estudio, además de etnografía proyectual a 30 personas provenientes del sector público, organizaciones ambientales y de pequeños agricultores. Resultados: El caso revela altos grados de distorsión en el acceso, uso y regulación de recursos socio-ambientales, asunto que corresponde a la dispersión y limitadas opciones de solución de los agentes institucionales públicos y privados responsables. Conclusiones: La interpretación de procesos territoriales que surgen al margen de la escala estrictamente sectorial, reconoce en el sustrato empírico de las redes sociales, la posibilidad de instaurar proyectos que mitiguen las condiciones de conflictividad socio-ambiental que producen en la escala local los efectos del cambio socio-económico global.
Rôle du dictionnaire de thème dans l'apprentissage du grec moderne
Authors: TONNET Henri
Published: October 2021

On se pose la question de l'utilité pédagogique des dictionnaires bilingues grec moderne-français et français-grec moderne. En d'autres termes, un francophone peut-il apprendre la langue grecque moderne en consultant des dictionnaires ? La question est abordée de trois points de vue : historique, descriptif et prospectif. Une très rapide histoire des dictionnaires grecs modernes montre qu'on s'y est toujours proposé d'y enseigner (essentiellement aux hellénophones) une langue plus "pure" que l'idiome parlé. Dans la réalité actuelle, les dictionnaires sont rédigés pour un public grec et dans une perspective commerciale. Pour être utiles aux apprenants français les dictionnaires devront prendre en compte les difficultés spécifiques du grec pour un francophone (distinctions lexicales inconnues en français, déclinaisons du nom, déplacements de l'accent, choix des aspects verbaux).
Impacto do adoecimento crônico em mulheres com Vírus Linfotrópico T Humano (HTLV)
Authors: Dos Santos Ana Clarissa Cerqueira , Sampaio Daniela Carneiro , Cordeiro Oliveira Lavinya Lima , Dos Santos Ribeiro Dhynar Alves , Sousa Bruna Rafaella Barreto , Rivemales Maria da Conceição Costa
Published: October 2021

OBJETIVO: analisar de que modo as alterações causadas pelo HTLV impactam no cotidiano das mulheres e as formas de enfretamento a presença do referido vírus. MÉTODO: pesquisa descritiva qualitativa realizada com utilização de dados secundários extraídos a partir da base de dados do projeto de pesquisa intitulado “Vivência da sexualidade: representações das pessoas soropositivas para o HTLV”. A coleta de dados foi feita com 12 mulheres HTLV positivas atendidas no ambulatório de infectologia de um Hospital Universitário em Salvador/BA; e no Centro de Testagem e Aconselhamento (CTA) do município de Santo Antônio de Jesus/BA, utilizando como estratégia metodológica o Discurso do Sujeito Coletivo. RESULTADOS: Os depoimentos e falas de mulheres soropositivas para o HTLV revelam o estigma vivenciado por elas, o afastamento de amigos e familiares após o diagnóstico do HTLV e o impacto negativo para as mulheres. Quanto às formas de enfrentamento para driblar o estigma, as mulheres ocultam detalhes relacionados à infecção pelo HTLV e encobrem totalmente sua condição sorológica, até mesmo para seus familiares. CONCLUSÃO: O HTLV causa impactos no cotidiano das mulheres que convivem com o vírus. Assim, a assistência de saúde prestada deve ser baseada no bem estar físico e biopsicossocial, contribuindo assim, com o enfrentamento do estigma no cotidiano da mulher soropositiva.
Educação clínica em enfermagem: desenvolvimento de uma casa simulada para a operacionalização de visita domiciliar
Authors: Da Silva Thiago , Hennemann Aline Carla , Souza Hilário Thamires , Greff Machado Denise , Lunardelli Adroaldo
Published: October 2021

OBJETIVO: Relatar a construção de uma casa simulada para implementação de cenários de alta fidelidade na realização de visita domiciliar pelos acadêmicos de Enfermagem com vistas à atenção primária à saúde. MÉTODO: Relato de experiência de professores realizado no período de março de 2019 a novembro de 2020. RESULTADO: A casa simulada exigiu esforço na montagem de sua infraestrutura física, pois conta com acústica controlada, equipamentos para gravação, espelho semitransparente e mobiliário funcional. O cenário implementado trata de um atendimento de um paciente com deficiência auditiva e que apresenta hipertensão arterial. Foi utilizado, também, um aplicativo para telefone móvel que auxilia na linguagem de sinais pode ser considerada como algo funcional e proveitoso. CONCLUSÃO: O cenário estruturado apresentado mostra uma maneira elegante de trabalhar as visitas domiciliares com os estudantes, que poderão exaurir seus esforços em um ambiente controlado para dilatar suas habilidades e tornarem-se regentes de qualidade quando chegado o momento da atuação profissional.
Características sociodemográficas e acadêmicas de estudantes de enfermagem em formação profissional
Authors: Saho Mari , Lomanto Georgina Almeida , Salviano Isabel Cristina de Barros , Reis Erenice Santos , Dos Anjos Karla Ferraz , Santa Rosa Darci de Oliveira
Published: October 2021

OBJETIVO: Descrever as características sociodemográficas e acadêmicas de estudantes de enfermagem de uma instituição de ensino superior sobre sua formação profissional. MÉTODO: Estudo descritivo, quantitativo, realizado com 197 estudantes do curso de graduação em enfermagem, matriculados em todos os períodos do curso.  Os dados foram coletados por meio de um questionário fechado autopreenchido e aplicado no período de maio a agosto de 2017. RESULTADOS: Evidenciou-se entre os estudantes de enfermagem o predomínio do sexo feminino (82,2%), solteiros (76,1%), com inserção no mercado de trabalho formal (49,7%), possuem filhos (44,7%), residem distantes da unidade de ensino (69%), utilizam transporte coletivo para deslocar para a IES (82,7%) e faz uso da internet como principal recurso para os estudos (91,4%). Entre as áreas de atuação almejadas durante a formação, tem-se a de assistência e da enfermagem obstétrica.  CONCLUSÃO: Verificou-se possíveis contribuições à estruturação do projeto pedagógico do curso, uma vez que o estudo traz elementos que caracterizam o perfil e algumas demandas acadêmicas dos estudantes que frequentam o curso de graduação em enfermagem de uma instituição de ensino.
Percepção da equipe multiprofissional: um cuidado necessário a pessoa com obesidade na unidade de terapia intensiva
Authors: Sebold Luciara Fabiane , Girondi Juliana Balbinot Reis , Amante Lúcia Nazareth , Pardal Bruna Machado , Kagaochi Thainá de Souza , Silveira Bárbara Mohr da
Published: October 2021

OBJETIVO: Conhecer a percepção da equipe multiprofissional sobre o cuidado à pessoa com obesidade em uma Unidade de Terapia Intensiva (UTI). MÉTODO: Estudo exploratório e descritivo, com abordagem qualitativa, desenvolvido em uma UTI do sul do Brasil, com 14 profissionais da equipe de saúde. Os dados foram coletados por meio de entrevista semiestruturada, entre junho e setembro de 2018, e a análise se deu por meio da análise de conteúdo de Bardin. RESULTADOS: Após análise das informações coletadas dos relatos dos participantes, emergiram quatro categorias: Dificuldades para a realização do cuidado; Cuidados Específicos; Gestão do cuidado: Equipe de Trabalho; Sentimentos e reações diante do cuidado às pessoas com obesidade. A equipe de saúde percebe algumas dificuldades para a realização do cuidado, mas que alguns são especiais, a gestão do cuidado está pautada na equipe de trabalho e no contexto ético. CONCLUSÕES: Os cuidados prestados pela equipe de saúde à pessoa com obesidade são realizados mesmo diante das adversidades relacionadas aos materiais, equipamentos, número de profissionais e questões éticas.
Atendimento de adolescentes na atenção básica de saúde durante a pandemia de Covid 19
Authors: De Melo Emily Tavares , Souza Ikaro Victor Ferreira , Amorim Carolaine Freitas , De Oliveira João Victor Lima , De Albuquerque Miriã Pontes , Da Costa Ruth Silva lima
Published: October 2021

OBJETIVO: Descrever o atendimento à saúde de adolescentes em uma unidade de saúde do Acre durante a pandemia de COVID 19. MÉTODO: Estudo transversal, exploratório, realizado junto a adolescentes em busca de atendimento em uma unidade de saúde. RESULTADOS: A maioria encontrava-se com 16 anos (40%), solteiros (90%), cor da pele parda (55%), renda familiar de 1 salário mínimo (63%), ensino médio incompleto (55%). Não exerciam trabalho remunerado (88%), não frequentavam religião (60%), moravam com os pais (75%), quando buscaram atendimento obtiveram êxito (100%). Dentre os motivos da busca por atendimento, destacou-se a consulta médica (35%), seguido da realização de exames (33%). Alegaram não possuir nenhum problema de saúde pré-existente (98%) e que não haviam participado de ação educativa nos últimos 12 meses (100%). Afirmaram não conhecer o agente comunitário de saúde de sua área de abrangência e que ele não realizava as visitas domiciliares regularmente (100%). A maior parte recebeu orientações dos profissionais de saúde durante o atendimento (80%) e achavam que as ações da unidade voltadas para os adolescentes eram satisfatórias (48,0). CONCLUSÃO: De forma geral, os adolescentes conseguiram acessar os serviços de saúde no seu loco região durante a pandemia e estavam satisfeitos com o atendimento.
THE MODEL OF STRENGTHENING NATIONAL IDENTITY IN THE CADRE PROCESS OF STUDENT ORGANIZATION
Authors: Sjam Darda Abdullah , Budimansyah Dasim , Nurdin Encep S. , Malihah Elly
Published: October 2021

This study aims to identify the model of strengthening the national identity through the cadre pattern in the Islamic Student Association organization (HMI). This study applied a qualitative approach with a case study method. Student organizations have a crucial role in providing insight, sense, and spirit of Indonesian nationalism that is wrapped in the frame of Unity in Diversity. One of the challenges faced by a student organization in Indonesia is the ability of this organization to protect its noble goals from certain interests, which can direct the activities to the issues that violate the motto. In this context, cadre in student organizations must strive to foster and strengthen the spirit of nationalism. The presence of a student religious organization provides its uniqueness that is noteworthy to study. Therefore, this study will identify how the concept of student religious organization regeneration, especially the Islamic Student Association. In this article, the researcher views that the cadre of a religious student organization such as the Islamic Student Association has a very unique and strong style of regeneration. It can be observed from the numerous cadres of Islamic Student Association who work in government, non-governmental organizations, and other sectors who are highly open with differences and voice about the importance of togetherness in unity, which is based on the ideology of struggle, i.e., pluralism, democracy, state administration, and law enforcement. The three struggle programs are determinative factors for caring for the National Identity (Unity in Diversity).
The Role of Female Coach Leadership on Martial Arts Athlete Achievements
Authors: Berliana B , Purnamasari Ira , Febrianty Mona Fiametta , Nurjaya Dede Rohmat
Published: October 2021

The purpose of this study was to reveal the success of female coaches in training elite sports. The method used was descriptive. The questionnaire was distributed to male and female athletes whom female coaches trained. The population involved in this study were eight female martial arts coaches (aged 25 to 45 years with training experience ranging from 5 to 15 years) and 72 martial arts athletes (35 male, 37 female) aged 15 to 40 years. The sport that was deliberately chosen was the martial arts sport. Martial art sport was chosen as female coaches in martial arts sports were still relatively few. The study results reported that there was a significant relationship between the leadership of female coaches and the performance of Judo athletes. Meanwhile, for Tae Kwondo, Tarung Derajat, Boxing, and Fencing sports, there was an insignificant relationship between female coach leadership and athlete achievement. Therefore, it is suggested to provide opportunities for female coaches to train martial arts sports.
Editors and Guidelines of the MIMBARDIK Journal, Issue of September 2017
Authors: MIMBARDIK Editor Journal
Published: October 2021

MIMBAR PENDIDIKAN: Jurnal Indonesia untuk Kajian Pendidikan (Indonesian Journal for Educational Studies) This journal, with ISSN 2527-3868 (print) and 2503-457X (online), was firstly published on March 11, 2016, by UPI (Indonesia University of Education) Press in Bandung and orgnized by the Lecturers of UPI Journal Developer Team. The MIMBAR PENDIDIKAN  is a new version journal from the old journal with the similar name that was published since 1995 to 2005. This journal is dedicated not only for Indonesian scholars who concern about educational studies, but also welcome to the scholars of Southeast Asian countries and around the world who care and share related to the educational studies in general. The MIMBAR PENDIDIKAN journal is published twice a year i.e. every March and September. Bandung, Indonesia: September 30, 2017.Prof. Dr. Didi SukyadiEditor-in-Chief of the MIMBAR PENDIDIKAN Journal in Bandung, West Java, Indonesia.
Protection of a Stationary Object from the Massive Impact of Mobile Objects under Conditions of von Neumann's Mixed Game
Authors:   Povolzhskiy State University of Telecommunications and Informatics, Samara, 443010, Russian Federation, Maslov O. N.
Published: October 2021

The method of statistical simulation modeling (SSM) has been used to analyze the operating conditions and the efficiency of the physical protection system of a stationary object from the massive impact of unmanned aerial vehicles (drones). It is shown that the conditions of the problem correspond to the reflexive version of a two-sided von Neumann's mixed game. statistical risk-oriented characteristics for two variants of the object protection system implementation using force mechanical and electromagnetic effects on the "drones cloud" are determined. The possibilities and the prospects for using the results obtained using the SSM method are presented.
Reconstruction of a Symbolic Periodic Sequence from a Sequence with Noise
Authors:   National Research University Higher School of Economics, Moscow, 101000, Moscow, Russian Federation, Zhukova G. N. , Ulyanov M. V. ,   V. A. Trapeznikov Institute of Control Sciences of Russian Academy of Sciences, Moscow, 117997, Russian Federation,   Lomonosov Moscow State University, Moscow, 119991, Russian Federation
Published: October 2021

The problem of constructing a periodic sequence consisting of at least eight periods is considered, based on a given sequence obtained from an unknown periodic sequence, also containing at least eight periods, by introducing noise of deletion, replacement, and insertion of symbols. To construct a periodic sequence that approximates a given one, distorted by noise, it is first required to estimate the length of the repeating fragment (period). Further, the distorted original sequence is divided into successive sections of equal length; the length takes on integer values from 80 to 120 % of the period estimate. Each obtained section is compared with each of the remaining sections, a section is selected to build a periodic sequence that has the minimum edit distance (Levenshtein distance) to any of the remaining sections, minimization is carried out over all sections of a fixed length, and then along all lengths from 80 to 120 % of period estimates. For correct comparison of fragments of different lengths, we consider the ration between the edit distance and the length of the fragment. The length of a fragment that minimizes the ratio of the edit distance to another fragment of the same length to the fragment length is considered the period of the approximating periodic sequence, and the fragment itself, repeating the required number of times, forms an approximating sequence. The constructed sequence may contain an incomplete repeating fragment at the end. The quality of the approximation is estimated by the ratio of the edit distance from the original distorted sequence to the constructed periodic sequence of the same length and this length.
Automated Feature Engineering Method in the Problem of Forecasting Energy Consumption
Authors:   National Research University Higher School of Economics, Moscow,101000, Russian Federation, Danilov K. V. ,   PJSC NLMK, Moscow, 119017, Russian Federation, Maltseva S. V. ,   National Research University Higher School of Economics, Moscow,101000, Russian Federation
Published: October 2021

The automated feature engineering method in the problem of forecasting energy consumption is considered. The algorithm of the method and the scheme of the forecasting model construction are stated. The proposed approach was tested on data about electricity consumption in Russian regions. The results of the computational experiments carried out using the described method demonstrate an increase in the efficiency of the developed forecasting model and improvement of accuracy.
National Curricular Parameters for Mathematics: From the Creation of the Kaleidoscope to the Necessity to Look Back to Move Forward
Authors: Godoy Elenilton Vieira , Britis Karen Gonçalves , Vianna Carlos Roberto
Published: October 2021

Background: In the last decades in Brazil, the prescriptions of the official curricular documents of school mathematics have been constituted as a practice of successive governments. However, there is still little research on the participation of mathematics teachers and educators in the construction of these prescriptions. Objective: To present the perspective of the research collaborator in the general coordination of the PCNs (National Curriculum Parameters) in the area of Mathematics (3rd and 4th cycles of elementary education). Design: This is a qualitative research, with the production of a documentary source through interviews with thematic oral history procedures. Setting and participants: The research collaborator was professor Dr. Célia Maria Carolino Pires, and the interviews were conducted at her residence. Data collection and analysis: Oral sources were used, in the form of interviews with a researcher in the field of mathematics education, as well as written sources that complemented the necessary information. Results: This article presents a thematic section that, on the one hand, makes public the opinions of a person who actively participated in the elaboration and diffusion of the PCNs; and, on the other hand, it invites us to reflect on how - in the last 50 years in Brazil - primary school teachers have had the opportunity to be supporting/protagonists in terms of curriculum production, and how this production has been conducted and understood as a government policy (and political parties) and not a State policy.  Conclusions: The article presents considerations made by a participant engaged in the process of elaborating and disseminating the Mathematics PCNs for the 3rd and 4th cycles of elementary education and - in addition - it was constructed to promote a reflection on more recent themes that include, for example, to think about how external assessments start to induce the production of curricula, functioning as thermometers that supposedly can capture the productivity indices of the school system and, at the same time, promote more symptoms of the illness they intend just to “gauge”
DETECTION OF MINIMAL TUMOR CELLS FOR THE DIAGNOSIS AND TREATMENT MONITORING OF CHILDREN WITH NEUROBLASTOMA
Authors: Shubina I. Zh. , Burlaka N. A. , Kazantsev A. P. , Dolzhikova Yu. I. , Petkevich A. A. , Kirgizov K. I. , Kiselevskiy M. V.
Published: October 2021

Diagnosis, treatment and designing an adequate strategy of neuroblastoma (NB) therapy in children is still a complicated tasks for pediatric oncology and hematology. One of the key aspects of NB control is detection and monitoring of minimal residual disease.

The authors make a concise review of the up-to-date methods, such as immunocytochemistry, fluorescent in situ hybridization (FISH), flow cytometry, the methods of qualitative and quantitative polymerase chain reaction (PCR) to estimate mRNA (RT-PCR and QRT-PCR), which are currently used for minimal residual disease detection in patients with NB. Disialoganglioside GD2, a specific NB marker, is traditionally determined by immunocytochemistry with fluorochromes that enhance its specificity, and by flow cytometry, as well. At present, FISH test is a gold standard for evaluation of the MYCN gen status in NB. A widely used multicolor flow cytometry method allows achieving high specificity of the analysis for NB diagnosis. RT-PCR may search for various targets to reveal NB cells, however, at the moment the only accepted immune target is tyrosine hydroxylase mRNA. Moreover, the studies established that quantitative QRT-PCR has more advantages than traditional qualitative RT-PCR, since this method allows a more accurate and quantitative detection of one or several mRNAs in clinical samples. The review discusses advantages and disadvantages of the main methods currently used for minimal residual disease evaluation of NB cells, such as RT-PCR, flow cytometry, FISH, etc. Comparative studies included multicolor flow cytometry with various combinations of CD9/CD81/CD56/CD45/GD2 monoclonal antibodies, conventional RT-PCR and quantitative QRT-PCR to reveal circulating/disseminated NB cells in the clinical samples of cancer patients and healthy volunteers.

The authors analyze the results of various studies that compared accuracy and sensitivity of diagnostic methods such as RT-PCR, flow cytometry, FISH and some others. Despite the advantages of each method, the authors emphasize that multicolor flow cytometry is the optimal approach for the rapid and reliable detection of minimal residual disease and micrometastases of NB.
ADHESION CONCEPT IN CANCER BIOLOGY: LOCAL AND CENTRAL MECHANISMS (PART 1)
Authors: Bocharova O. A. , Matveev V. B. , Bocharov E. V. , Karpova R. V. , Kucheryanu V. G.
Published: October 2021

The review presents the concept the key mechanism of the tumor process is a violation of adhesion interactions involving local and central mechanisms. Local features of adhesive dysregulation are demonstrated in the first part. The lack of histospecific adhesion molecules expression resulting from stress or genetic mutation damages an important mechanism of antitumor protection of the tissue disrupting the processes of proliferation and differentiation. The deficiency of histone-specific homotypic adhesion molecules which occurs later exacerbates the disorders. This leads to a decrease in the expression of leukocyte integrins (LFA-1, Mac-1) ligands of the β2 family on the surface of immune effectors and to an increase also in the expression of adhesion molecules to the substrate-antigens VLA (very late activation) family of β1 -integrins on tumor cells. The first restricts the interaction of ICAM family molecules with their contra-receptors from the β2 -integrin family reducing the elimination of target cells by immune effectors which contributes to the screening of the tumor from antitumor surveillance. The second promotes the invasion of the tumor into the surrounding tissues, the formation of blood vessels as well as its heterotypic adhesion with other tissues which further stimulates the proliferation and suppression processes of tumor cells apoptosis. So, the adhesion molecules can be compared to the Phoenix bird: disappearing at the beginning of the process (between the similar cells), they reappear in a new quality (increasing adhesion to cells of other tissues), increasing the totalysm of the tumor. It should be taken into account that tumor cells due to adhesion dysregulation “isolate themselves from society”, lose their differentiation, their maturity and “fall into childhood”, being unable to perform specific, “adult” functions. So, cancer can be considered as a manifestation of the cells aging. Therefore, the anti-stress, endogenous geroprotective mechanisms activation based on the adhesion correction can be effective for preventing and treatment the oncological process.
DEVELOPMENT OF POLYMERIC MICROPARTICLES WITH RADACHLORINE AND ESTIMATION OF THE PROSPECTS OF THEIR USE IN PHOTODYNAMIC THERAPY
Authors: Miroshkina A. M. , Krechetov S. P. , Solovieva N. L. , Krasnyuk I. I.
Published: October 2021

Introduction. Nowadays, the development of delivery systems based on micro- and nanoparticles is being actively pursued to increase the selectivity and efficiency of photosensitizers in photodynamic therapy. Such microparticles could increase the effectiveness of the already used chemotherapeutic drugs due to their accumulation in the tumor and help to overcome the drug resistance of tumor cells.

The aim of this research was to obtain microparticles based on a biocompatible block copolymer of lactic and glycolic acids with the inclusion of the photosensitizer radachlorin, magnetic nanoparticles, and perfluorodecalin and their subsequent evaluation as therapeutic agents for photodynamic therapy.

Materials and methods. Microparticles were obtained using the double emulsion method, described using of electron microscopy. Evaluation of their photodynamic properties was carried out using spectrophotometry and MTTtest on cell culture.

Results. Spherical microparticles with a size of less than 1 μm were obtained. The release of the active substance from microparticles occurred gradually over two weeks, and in the case of the presence of magnetic nanoparticles, the concentration of radachlorin remained practically unchanged for a month. Exposure of microparticles to the light of LED is accompanied by the formation ofsinglet oxygen. Electron microscopy indicated intracellular position of microparticlesin tumor cells. The MTT test revealed a significant inhibition of cell viability in the presence of microparticles.

Conclusion. The research results allow us to consider the obtained biocompatible polymer microparticles with the inclusion of radachlorin as a depot of radachlorin for local use in photodynamic therapy of tumors.
Increasing the medico-economic efficiency of preventive counseling for patients with arterial hypertension and behavioral risk factors for non-communicable diseases
Authors: Zadvornaya O. L. , Pishchita A. N.
Published: October 2021

Objective:to evaluate behavioral risk factors (BRF) in patients with arterial hypertension (AH) and to determine the ways of improvement of the approaches to preventive consulting targeted to increase medico-economic efficiency of the prevention of cardiovascular diseases (CVDs).

Material and methods.A total of 107 patients aged 40–60 years old that attended health-promoting schools for patients with AH at the institutions of primary medical help in Moscow in 2017–2019 were surveyed. The authors used diagnostic criteria of the risk factors for noncommunicable diseases that have behavioral character according to the classification of the World Health Organization (WHO). Along with that, the authors reviewed the opinion of 128 top managers of the institutions of primary medical help that attended the courses of their qualification improvement “Organization of public healthcare” in 2019. The course was dedicated to the possible ways of improvement of preventive consulting of patients with AH and BRF. The methods of content analysis, synthesis, statistical analysis, comparison, etc. were applied. The authors analyzed the documentation on the prevention of CVDs, scientific publications on the subject from eLibrary, Cochrane Library, PubMed, Scopus databases, and official sites of biomedical journals.

Results.The sociological survey revealed data on the presence of BRF of non-communicable diseases in patients aged 40–60 years old with verified AH based on scientifically proven criteria and WHO classification. These criteria allowed to evaluate the degree of the proneness of patients with AH to the influence of harmful risk factors (smoking, alcohol consumption, lack of physical activity, unhealthy eating habits) and their combinations. The sociological survey data obtained from the top management of institutions of primary medical help indicated the necessity of the improvement of approaches to group preventive consulting of patients with AH and BRF.

Conclusion.The results of the study revealed the main areas of the systemic mistakes in the preventive consulting of patients with AH that have BRF, associated with the evaluation of individual-psychological peculiarities of a personality, and in the organizational aspects of preventive counseling.
Pharmacoeconomic analysis of the application of strong opioids for the treatment of chronic pain syndrome in patients with pancreatic cancer
Authors: Bobrova O. P. , Zyryanov S. K. , Shnayder N. A. , Petrova M. M.
Published: October 2021

Objective: to evaluate the clinical and economic feasibility of opioid therapy based on the analysis of its cost and effectiveness in patients with chronic pain syndrome in pancreatic cancer.

Material and methods. An observational prospective study in parallel groups of patients with chronic pain syndrome associated with pancreatic cancer was carried out. The analysis of cost minimization and cost-effectiveness was applied, as well as pharmacoeconomic modeling, which included the construction of a decision tree in patients receiving morphine sulfate (n=45) and fentanyl TTS (n=45) for pain relief. The sensitivity of the obtained data was assessed using one-way analysis.

Results. It was shown that the treatment of chronic pain syndrome in patients with pancreatic cancer with opioid analgesics as part of combined treatment is the least expensive in the morphine sulfate group (incremental cost-effectiveness ratio 144.93). Based on the results of modeling, the prognostic factors of influence on the cost of analgesic therapy were determined: the cost of combined analgesic therapy, the cost of treatment of adverse reactions, and the cost-effectiveness ratio.

Conclusion. Analgesic therapy of chronic pain syndrome with morphine sulfate in patients with pancreatic cancer is pharmacoeconomically feasible.
Pharmacoeconomic evaluation of the effectiveness of therapy for metastatic colorectal cancer
Authors: Petukhova Yu. Yu. , Eliseeva E. V. , Volkov M. V. , Li O. N. , Petukhova A. G.
Published: October 2021

Objective: to perform a pharmacoeconomic evaluation of the effectiveness of therapies for metastatic colorectal cancer (mCRC) based on real practical data on medical help for patients with this disease.

Material and methods. The authors performed a comparative cost-effectiveness analysis and the calculation of resource consumption in the application of several options of chemotherapy for mCRC: FOLFOX, FOLFIRI, and FOLFOXIRI; targeted therapy: FOLFOX + bevacizumab, FOLFOX + panitumumab, FOLFIRI + cetuximab, FOLFIRI + aflibercept, regorafenib monotherapy.

Results. The cost-effectiveness parameter, calculated as a ratio of the cost of therapy to the median survival without progression, for chemotherapeutic schemes varied from 108 to 167 thousand rubles and for the targeted therapy schemes – from 223 to 930 thousand rubles. The calculation of resource consumption showed that in the case of a limited budget, 100% of patients can be treated by FOLFOX scheme, or 26% of patients by FOLFOX + panitumumab, or 47% of patients by FOLFOX + bevacizumab; and 100% of patients by FOLFIRI scheme or 11.5% of patients by FOLFIRI + cetuximab (aflibercept). Besides, it was established that in the case of a similar budget, 100% of patients with mCRC can be treated by chemotherapy schemes or a limited number of patients with regorafenib.

Conclusion. The cost of targeted therapy significantly exceeds the cost of chemotherapeutic schemes. Still, considering the gross domestic product per capita in the Russian Federation, they can be an economically feasible investment and the optimum option of therapy
The concept of syndromic diagnoses of osteoarthritis and back pain as a cause of therapy failure
Authors: Putilina M. V. , Teplova N. V. , Gerasimova O. S.
Published: October 2021

Osteoarthritis is considered a peripheral joint disease and is often ignored when discussing the prevalence and treatment of back pain. Traditionally, clinical guidelines from various countries are devoted to the treatment of nonspecific back pain (lower back pain), although this diagnosis is syndromic and is absent in ICD-10. Therefore, in real clinical practice, such diagnoses as osteochondrosis and dorsopathy simultaneously exist. The treatment strategies for back pain do not take into account chronic inflammation directly related to pro-inflammatory cytokines and oxidative stress, which makes drug therapy ineffective. It is advisable from the first days of therapy to choose parenteral forms from the group of symptomatic slow-acting drugs containing chondroitin sulfate (Chondroguard®), which will accelerate the onset of the analgesic effect and increase the effectiveness of pathogenetic therapy.
Review of methods for planning the scope of medical care and financing of the healthcare system by the subjects of the Russian Federation
Authors: Kovaleva S. A. , Fedyaev D. V. , Sisigina N. N.
Published: October 2021

The article presents a review of current and alternative methods for planning the scope and financing of medical care in the subjects of the Russian Federation. The relevance of the issue is due to the imperfection of the current planning model, which stimulate representatives of the profile bodies and independent experts to develop alternative methods. The current approaches and legal documents regulating the procedure for distributing the scope of medical care and financial resources to pay for this care are discribed. The analysis of alternative methods shows how different demographic and infrastructural features of regions can be used to redistribute the scope of medical care and the corresponding financial support.
Assessment of Inclusive Culture in a Preschool Educational Organization
Authors: Shemanov A.Y. , Samsonova E.V.
Published: October 2021

The purpose of the article is to discuss the characteristics of the tool for assessing the inclusive culture of a preschool educational organization, which involves not only examining the perception and attitude to the values of inclusion, but also making a statement of the observed parameters of their implementation in educational practice. Method: the results of a pilot study using a survey of teachers (N=46) and parents (N=78) according to the author's questionnaires are considered as a reflection of the problems of implementing the declared values of inclusive culture in the conditions of preschool educational organizations. Results: it was shown that, despite the generally positive assessment of the need to create conditions for the accessibility of the educational environment, support for children's initiative, and acceptance of all children, some respondents note the facts of rejection and exclusion from communication of some children, non-support of children's initiative. Conclusions: a questionnaire that includes specific indicators reflecting the implementation of inclusive values, in case of an interested answer to the questions posed, will allow respondents to assess the gap between the declaration and implementation and take steps to change the organizational culture towards greater inclusiveness, provided that the management supports inclusion and the involvement of subjects of educational interaction in changing it.
Overview of the 2nd International Congress on Civil Comparative Studies
Authors: Morgunova E. A.
Published: October 2021

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External study possibilities of a dead body solution about the death occurrence from psychotropic and narcotic drug poisoning
Authors: Travenko Elena N. , Porodenko Valeriy A.
Published: October 2021

Background: Poisoning with psychotropic and narcotic substances is still leads to the general structure of fatal intoxications. A decreased traditional psychotropic and narcotic drug fatal poisoning and an increased new synthetic psychoactive substances and combined consumption are recorded in the country. Aims: This study aimed to study the dynamics of drug poisoning incidence according to the annual report data in 20172020 in the Krasnodar territory and establish their predominant etiology. Analyze the medical literature and identify the data mostly described during the external examination that suggests narcotic drug exposure possibility of the body. Comparison of the literature and external examination results of the corpse from the Expert Conclusions (Acts of forensic medical research) to further use the signs to create a profile of the suspected poisoned corpse with narcotic substances. Material and methods: The study material includes the annual reports of the State Budgetary Healthcare Institution Bureau SME of the Ministry of Health of the Krasnodar Territory in 20172020, archival medical documentation autopsy reports in cases of death from narcotic substances; domestic and foreign literary sources. Results: In the Krasnodar Territory, opiates account for a large proportion of drug deaths. Psychotropic and narcotic drug intake is often (up to 30%) combined with alcohol consumption. The study showed that forensic pathology rarely uses external signs that make up the profile of a corpse suspected of drug poisoning at the initial stage. The most common signs (in 50% of cases) were: injection traces, cyanotic and flushed face, conjunctival hemorrhages, and whitish-pink foam in the nose or mouth openings. Others were not given due attention. Conclusion: The research topic dictates the need for further study and problem development, accumulation, and systematization of the obtained material for subsequent use.