bluuebunny/crossref_metadata_2025 huggingface dataset:
LEGAL ORGANIZATION OF SALES PORTS SAFETY MEASURES IN THE BLACK SEA REGION OF RUSSIA IN THE 19TH AND EARLY 20TH CENTURIES
Authors: Sharmoiants Artur N. , Klimenko Ekaterina P. , Zmerzly Boris V. , Ivashenko Ekaterina S. , Nikitina Alina P.
Published: October 2019

Purpose: Based on the analysis of legal acts and work of other researchers, a historical and legal analysis of the security measures organization was done for trading ports of the Black Sea region of Russia in the 19th and early 20th centuries in this paper.

Methodology: This study was based on a dialectical approach to studying the legal phenomena and processes by using general scientific (system, logical, analysis and synthesis) and private scientific methods.

Result: The following main components of the legal organization of security measures that are complex in nature: quarantine service; customs; pilot organizations; and port controls. The quarantine and customs authorities included quarantine and, accordingly, border guards. The tasks faced by these bodies were of anti-epidemiological measures nature, i.e. the prevention and detection of offenses with an economic, social and political persuasion.

Applications: This research can be used for businessmen and students in economy.

Novelty/Originality: In this research, the model of sales ports safety measures in the black sea region of Russia in the 19th and early 20th centuries is presented in a comprehensive and complete manner.
ISSUES AND CHALLENGES OF FUTURE NEWSPAPERS
Authors: Othman Siti Suriani , Nayan Liana Mat , Tiung Lee Kuok , Hassan Fauziah
Published: October 2019

Purpose of the study: This paper reviews recent literature on issues and challenges of the future newspaper. It traces issues and challenges that generally impacting the journalism industry worldwide and may be applied for future studies that shall further examine this matter empirically.

Methodology: This is a discussion paper that does not apply any research method. The discussion is done based on recent reviews related to the issue of the future of the newspaper and its trend.

Main Findings: Based on the review, there are five major issues and challenges identified which are the decline in newspaper circulations around the world, and the shrinking size of the industry. Following Wahl-Jorgensen et al. (2016), risks and threats, opportunities and digital journalism are fundamental questions that constitute a discussion of the future of the newspaper. Among the clear risks and threats is the issue of circulation, the emergence of the digital industry and its business model, social media and smartphones and several other issues such as identifying the direction of the newspaper's future discussions covering false news, speed of information (risks and threats), digital business model and the role of major industry players in digital world such as Google (opportunities) besides data and computer journalism (digital journalism). This discussion concludes that the future of the newspaper is seen to be very influenced by the emergence of digital journalism while the print version will continue to be vulnerable. The main issue which is seen as a threat is false news and information verification methods.

Applications of this study: The above main findings may be used for further empirical investigation on the future of the newspaper in various countries in the world. The findings may also inform media practitioners on the current issues and challenges the industry is facing in general, and on what is being researched and discussed by academia on this topic.

Novelty/Originality of this study: This discussion provides a summary of issues and challenges of the future of newspaper and this will enable readers to identify the main issues surrounding this topic. So far, there have been studies and discussions, but this paper presents the main issues and challenges on this topic in a systematic way based on recent previous studies and media reports.
A STUDY ON PSYCHOLOGICAL CAPITAL BY A METHOD OF SEMANTIC DIFFERENTIAL
Authors: Trofimov Andrii , Miliutina Kateryna , Drobot Olga , Lyuta Lesya , Otych Dariia , Pustovyi Sergey , Karamushka Taras
Published: October 2019

Purpose of the study: The purpose of the study is to create and to test a method based on the principles of semantic differential and to check the level of its consistency with the method of PsyCap.
Methodology: The study was conducted in Ukraine, at the first stage, there were 112 adult participants, where 52 were men and 60 were women. The second stage involved 69 people who were getting second higher education. For the purpose of mathematical and statistical processing of the obtained data, the SPSS 21 program was used, factor analysis and correlation analysis were performed.
Main Findings: The conducted research made it possible to reveal the semantic space of the "work" concept, and to distinguish four main factors: stability, effectiveness, relations in the team and discipline. They do not coincide with the parameters of the PsyCap, which include self-confidence, the ability and willingness to make efforts to successfully accomplish complex tasks - that is efficiency; optimism - a positive attributive style regarding the success of current and future activities; hope - vision of the perspective, purposefulness in the construction of activity; resilience - ability to overcome difficulties, solve problems in the process of achieving the goal.
Applications of this study: The study could be useful for HR-specialists, psychologists, and employees in different spheres.  In further research, it is desirable to continue the testing and standardization of the semantic differential "Attitude to work" and to conduct a cross-cultural study to find out if these factors of attitude to work are purely Ukrainian, or they are more general in nature.
Novelty/Originality: Modern methods of studying psychological capital are cumbersome and unprotected from the influence of socially desirable responses. Therefore, there was a need to create a smaller procedure based on the principles of the semantic differential.
APOS analysis on cognitive process in mathematical proving activities
Authors: Syamsuri Syamsuri , Marethi Indiana
Published: October 2019

Thinking is very necessary in learning mathematics, both at school and college level. Several studies have attempted to reveal students' thinking in learning mathematics at college. This article aims to describe the mental structure that occurs when constructing mathematical proofs in terms of APOS theory. The APOS theory has been widely used in analyzing the formation of mathematical concepts in universities. This research explores a thinking process in proof constructing. It uses a qualitative approach. The research was conducted on 26 students majored in mathematics education in public university at Banten, Indonesia. The consideration of that was because the students were able to think a formal proof in mathematics. Results show that there are two types of thinking process in mathematical proving activities, namely:  the deductive-holistic and the inductive-partial type of thinking process. Based on the results, some suitable learning activities should be designed to support the construction of these mental categories.
PERAN PEMERINTAH KOTA MALANG DALAM MENINGKATKAN KESIAPSIAGAAN MASYARAKAT MENGHADAPI BENCANA (STUDI MANAJEMEN BENCANA)
Authors: Rusli Rusli , 'Ulya Ayu Fitriatul
Published: October 2019

In Indonesia, the dangers of disasters such as floods, droughts, storms, and landslides have caused much loss of human lives and livelihoods, economic and infrastructure degradation, social order changes as well as environmental damage. In the face of disasters, the improvement of the system's preparedness in the community to reduce the risk of hazards is done through mitigation and adaptation efforts. Under Law No.26 of 2007 on spatial planning confirms disaster mitigation to be an important aspect of attention. Malang city of East Java including the recorded area is potentially prone to disasters, either flood, landslides, tectonic earthquakes or volcanic earthquakes. This study aims to determine the efforts of Malang City Government to improve community preparedness in facing the threat of disaster in Malang. The method used is positivism approach with qualitative approach. The result of this research indicates that the readiness of Malang City Government in facing disaster is with structural and non-structural mitigation. The structural mitigation effort that is done is the improvement of urban drainage channels, increasing the RTH and RTNH, incessant in the greening program by building a city park where as a tourist place is also useful for urban RTH, river normalization, reforestation on the banks of the Brantas river and other small rivers and cutting big trees on the street. While the effort in non-structural mitigation is the existence of regional regulations governing disaster (Malang Regional Regulation No. 1 of 2017 on Disaster Management Implementation, Strategic Plan (RENSTRA) BPBD Malang City 2015 - 2018), build synergy program with all actors (ministries, state institutions, social organizations, business entities, and universities) to empower communities, simulate increased knowledge and community awareness, increase community capacity to reduce and adapt to disaster risks by simulating and direction.

Keywords: disaster; preparedness; mitigation
PERBEDAAN RELIGIUSITAS DAN MOTIVASI BERPRESTASI PADA MAHASISWA UNIVERSITAS ISLAM NEGERI UIN MAULANA MALIK IBRAHIM MALANG
Authors: Susilawati Samsul
Published: October 2019

Religiosity is a religious appreciation and depth of trust expressed by daily worship, prayer, and reading of scripture. Religiosity can give a positive role to achievement motivation for the student. Correct understanding of his religion and the constant practice of his religious beliefs that will distinguish someone from others. Without a true understanding and practice of his religious beliefs, a necessity will form skilled individuals, initiative, leadership, responsible, honest, disciplined, loyal, optimistic, passionate and tolerant. Religious perspectives can play a positive role in relation to the achievement that the student will achieve in completing his education through understanding and belief in his religion. The higher the person's religious level the easier it will be for them to better complete their duties and responsibilities and to strive for difficulties in the face of religious values.

Keywords: religiosity; achievement motivation
WOMEN RESISTANCE IN EKA KURNIAWAN’S CORAT-CORET DI TOILET SHORT STORY COMPILATION BOOK
Authors: Furoidah Asri
Published: October 2019

Eka Kurniawan's Corat-coret di Toilet short stories compilation book contains twelve short stories that tell about light stories everyday but full of social criticism. Some of the short stories that portrayed female characters presented women who were not free in their lives, one of which was titled Dongeng Sebelum Bercinta and Si Cantik yang Tak Boleh Keluar Malam. Therefore, this study aims to analyze the position of women and their resistance toward patriarchal domination. This is interesting to be studied further by using feminist theory to find the position of women in literary works written by male writers. This research will focus on the actions of female characters which shape their position in the story. The data used in this study are in the form of words, sentences or expressions from short stories that show the dominance of patriarchy towards women and their efforts to get out of domination. From research using feminist theory it was found that patriarchal domination arises in the closest male characters to female characters such as fathers, male friends and husbands. Women resistance in the story was a form of false resistance which in turn strengthened the dominance of patriarchy and the dichotomy between men and women. This was found based on the fact that every resistance made by women turned to weaken women themselves.

  
Jaime Ros Bosch, economista
Authors: Casar José I.
Published: October 2019

El ensayo pasa revista a la vida y obra académicas de Jaime Ros, economista mexicano recién fallecido. Pone en relieve sus principales contribuciones teóricas y empíricas al análisis del desarrollo y el crecimiento, así como sus aportes en el campo del análisis de la macroeconomía y la política económica en México y América Latina.
Climate Change Induced Flood and Landslides and Farmer’s Adapatation Practices in Paddy Production: Evidence of Rural Hilly Nepal
Authors: Bista Raghu Bir , Dahal Ranjan Kumar
Published: October 2019

Climate change is a buzzword in the world. Scientist has approved it as global warming with its projection of undesired and unpredicted frequent extreme events and their vulnerabilities not only at present but also at future. There is an assumption of occurrence of adaptive capacity and behavior of farmers in agriculture production activity at some extent to neutralize climate change vulnerabilities of flood and landslides on paddy production. This paper empirically examines the effects of climate change in paddy production and farmer’s adaptive behaviors to neutralize such climatic shocks and events in paddy production by employing CD production function based econometric model. The study employed primary data collected through 642 household surveys. The study finds that climatic shocks and events have huge loss (60%) in paddy production and revenue income in such plot where farmers have not indigenous knowledge and practices. But both small and larger farmers who have adaptive capacity and behavior with their indigenous knowledge have less loss in paddy production and revenue income, although they have heterogeneity in their socio economic characteristics (income, asset holding, literacy, experience, land holding and age). The farmers who have used adaptive behavior have indigenous knowledge and experiences including bamboo wall construction to control flood and landslides and seed change to resist climatic shocks and events. In hilly region, the farmers have not sufficient alternative measures, except both adaptive measures because of their poverty, illiteracy and remote locations. The study finds their higher effective level to minimize vulnerabilities to paddy production and revenue per farm plot, although these adaptive behaviors are cost effective and local entity. Comparatively, bamboo wall construction is more effective measure in the paddy production than others are (seed switch) to minimize the flooding materials from the flood and the landslides. Thus, low cost indigenous adaption behavior of farmers is effective measure to climate change and climate change induced disasters and events vulnerability in paddy production.
Determinant Factors of Successful Ex Situ Conservation of Lesser Bird of Paradise [Paradisaea minor Shaw, 1809]
Authors: Cita Ken Dara , Hernowo Jarwadi Budi , Masy'ud Burhanuddin
Published: October 2019

Recently, the population of the lesser bird of paradise (Paradisaea minor Shaw, 1809) has been decreasing due to illegal hunting, illegal trading, and habitat destruction. Meanwhile, ex situ conservation efforts of this bird are lacked and very low in the success of breeding. The aims of this research were to identify and analyze the component that determines the successful ex situ conservation of the lesser bird of paradise. The study was conducted from March until May 2016 in the TMII Bird Park, Mega Bird and Orchid Farm (MBOF), Ragunan Zoo, Bandung Zoo, and Al Wabra Wildlife Preservation (AWWP) in Qatar. Data
included an internal and external biological aspect of species, captive breeding technique, and social aspect, and were analyzed by Principle Component Analysis (PCA). The statistical analysis resulted that there were five determinant factors of successful ex situ conservation of lesser bird of paradise which the first determinant factors were maturity, diet, and ability of animal keeper.
Experimental and Theoretical Research of a Hot Condition of High Pressure Cylinder of the T-100-130 Steam Turbine
Authors: Kudinov V. A. , Kotova E. V. , Kurganova O. Yu. , Tkachev V. K.
Published: October 2019

The results of experimental and theoretical studies of the temperature state of the high- pressure cylinder (HPC) of the T-100-130 steam turbine for one of the start modes are presented. Taking into account the dependence of the coefficient of linear expansion on the temperature, the elongations of the individual sections of the casing under different temperatures and its total elongation after the turbine operation starts to correspond to the stationary operation mode have been found. The studies have shown that in the process of actuation the turbine there is a significant difference in temperature along the length of the HPC casing. In this case, the most intense heating occurs in the area from the second to the sixth section. The greatest temperature difference was observed in stationary operation at maximum temperature in the fifth section. Using the orthogonal method of L. V. Kantorovich, an approximate analytical solution of the thermal conductivity problem for a two-layer wall (turbine casing – thermal insulation) under inhomogeneous boundary conditions of the third kind is obtained. With the use of experimental data on the temperature state of the outer surface of the casing of the HPC by solving the inverse problem of thermal conductivity, the average heat transfer coefficients for the actuation period characterizing the intensity of heat transfer from steam to the casing have been found. On the basis of experimental data on the temperature change of any of the controlled parameters of the turbine over time, a theoretical method for predicting its change in a certain time range from the time of the its last measurement has been developed. The use of this method to predict the change in the temperature difference between the top and bottom of the HPC casing during the actuation showed that for a period of time equal to 3–5 minutes the forecast is fulfilled with high reliability.
Waterproofing spray-associated pneumonitis: review of 29 cases and comparisons with acute eosinophilic pneumonia and hypersensitivity pneumonitis
Authors: Shimoda Masafumi , Tanaka Yoshiaki , Fujiwara Keiji , Furuuchi Koji , Osawa Takeshi , Morimoto Kozo , Yano Ryozo , Kokutou Hiroyuki , Sasaki Yuka , Yoshimori Kozo , Ohta Ken
Published: October 2019

Purpose: Waterproofing spray-associated pneumonitis (WAP) proceeds to acute respiratory failure and is characterized by diffuse bilateral ground-glass opacities on computed tomography. These features are similar to those of acute eosinophilic pneumonia (AEP) and hypersensitivity pneumonitis (HP). This study identified the characteristics of WAP and compared them with those of AEP and HP. Methods: We conducted a retrospective study of adult patients with WAP, AEP, and HP in Fukujuji Hospital from 1990 to 2018. Furthermore, data from patients with WAP were collected from publications in PubMed and the Japan Medical Abstracts Society and combined with data from our patients. Results: Twenty-nine patients with WAP, eleven patients with AEP, and thirty patients with HP were reviewed. There were no significant differences between the characteristics of WAP and AEP patients, such as age, sex, smoking habit, and laboratory findings. The features of WAP and HP were significantly different. The duration from symptom appearance to hospital visit was shorter in patients with WAP (median 1 day) than in patients with AEP (median 3 days, p =0.003) and HP (median 30 days, p <0.001). The dominant cells in the bronchoalveolar lavage fluid of patients with WAP, AEP, and HP were different (respectively macrophages, eosinophils, and lymphocytes). Conclusions: It was easy to distinguish between WAP and HP because there were many different features. However, the features of WAP and AEP were similar, making differentiation between those two diseases difficult. To distinguish among WAP, AEP and HP, the speed of disease progression and a bronchoscopic examination are very important.
Virulence-associated characteristics of carbapenem-resistant Klebsiella pneumoniae in hospital-acquired infections: results from a hospital in central China
Authors: Pengwen OUYANG , JIANG Bin , WANG Juan , PENG Na , YE Jianrong , CHEN Yiping , XIE Liangyi
Published: October 2019

Background Carbapenem-resistant Klebsiella pneumoniae (CRKP) have been a clinically significant pathogen worldwide, but related reports about their virulence features in hospital-acquired infections (HAI) are pretty lacking.Methods CRKP causing HAI were continuously collected in 2018 from a hospital in central China. Isolates identification and antimicrobial susceptibility test were done using VITEK-2 compact system or MALDI-TOF MS. String test, multilocus sequence typing, carbapenemase genes, virulence genes and capsular antigen genes detection were conducted to understand their phenotype and genetic background. As well as case datas were collected and compared to assess their virulence characteristics.Results A total of 62 isolates of CRKP from 62 patients with HAI were collected. 41 carbapenemase genestic-confirmed hypervirulent Klebsiella pneumoniae (CR-hvKP) and 21 carbapenem resistant non-hypervirulent Klebsiella pneumoniae (CR-NhvKP) were screened out. Most CRKP causing HAI were ST11 KPC-2 producing strains and maily causing pneumonia. Only for blaKPC-2 there was a significant difference between CR-hvKP and CR-NhvKP (p<0.001). No significant difference of the two group strains in resistance against amikacin, trimethoprim-sulfamethoxazoleare, cefepime, ceftazidime, imipenem, piperacillin-tazobactam, colistin and tigecycline were found except levofloxacin (p<0.001), and all strains showed sensitive to tigecycline and colistin. In the CR-hvKP group, IucA (64.5%) were the most commonly detected virulence gene, followed by iroN (48.4%), prmpA2 (30.6%) and prmpA (4.8%), only 1 (2.4%) capsular serotype positive strain and 2 (4.9%) hypermucoviscosity phenotype strains were detected, while no hypermucoviscosity phenotype or capsular antigen gene positive strain was detected in the CR-NhvKP group. And there was no significant difference between the two groups in age, types of infection, departmental distribution, survival time or the final outcome of infection.Conclusion ST11 KPC-2-producing Klebsiella pneumoniae are most prevalent CRKP in HAI. Virulence gene espacially iucA has a high proportion and worth paying attention to. Hypermucoviscous phenotype and virulence-associated capsular serotype in CRKP both have a low prevalence. CRKP harboring virulence genes have a higher expression of KPC-2 and less sensitive to levofloxacin than those harboring no virulence gene, and there is no significant difference for virulence manifestations between the two groups.
Prevalence of Frailty and Reliability of Established Frailty Instruments in Adult Elective Colorectal Surgical Patients: a Prospective Cohort Study
Authors: Howell Simon James , Baker Oliver , Burke Dermot , MacLaine Thomas Dale
Published: October 2019

Background: Frailty is associated with adverse outcome in older surgical patients but the strength of the association varies widely between studies. This may be due in part to the wide range of instruments used to assess frailty. Large population studies now demonstrate that frailty is prevalent in all adult age groups. However, there are limited data on the association between frailty and surgical outcome in younger patients. We studied the agreement between three established frailty instruments and their predictive value for postoperative complications in an adult colorectal surgery population. Methods: We studied patients aged 18 years or over presenting for elective colorectal surgery at a major teaching hospital. Preoperative frailty assessments were performed using the clinical frailty scale (CFS), accumulation deficit (AD) and frailty phenotype (FP) instruments. Data were collected on postoperative complications, length of stay, and readmission. The correlation and agreement between the frailty measures was examined in pairwise comparisons. Measures of association and prediction for postoperative complications were calculated and compared for the instruments. Results: Frailty scores were recorded in 200 patients (91 male), mean(range) age 57(18-92) years. The prevalence of pre-frailty was 52-67% and that of frailty 2-32% depending on the instrument used. Agreement between the instruments was poor, kappa 0.08 to 0.17 in pairwise comparisons. Outcome data were available on 160 patients. Only the frailty phenotype was significantly associated with adverse outcomes, odds ratio 6.1(1.5-24.5) for postoperative complications. The three frailty scoring instruments studies had good sensitivity (CFS-90%, AD-96%, FP-97%) but poor specificity (CFS-12%, AD-13%, FP-18%) for the prediction of postoperative complications. All three instruments were poorly predictive of adverse outcomes with likelihood ratios of CFS-1.03, AD-1.03 and FP-1.12. Conclusions: This study showed a significant prevalence of pre-frailty and frailty in adult colorectal surgical patients of all ages. There was poor agreement between three established frailty scoring instruments. Our data do not support the use of current frailty scoring instruments in all adult colorectal surgical patients. However, the significant prevalence of pre-frailty and frailty across all age groups of adult surgical patient justifies further research to refine frailty scoring in surgical patients.
Clinical course of grafted cartilage in osteoarticular frozen autografts for reconstruction after resection of malignant bone tumor involving an epiphysis
Authors: Hayashi Katsuhiro , Yamamoto Norio , Takeuchi Akihiko , Miwa Shinji , Igarashi Kentaro , Higuchi Takashi , Abe Kensaku , Taniguchi Yuta , Aiba Hisaki , Araki Yoshihiro , Yonezawa Hirotaka , Morinaga Sei , Tsuchiya Hiroyuki
Published: October 2019

Background: There are several options for biological reconstruction after bone tumor resection. If the tumor invades an epiphysis, the reconstruction is far more complicated because there is no option to restore large joint cartilage using currently available medical techniques. Frozen autograft with liquid nitrogen has been used as recycled autologous bone graft and the purpose of the present study was to assess the outcome of grafted cartilage in osteoarticular frozen autografts used in the treatment of patients with bone and soft-tissue sarcoma.
Method: We have treated 27 patients with cases of bone tumor resection involving an epiphysis where frozen autografts were used for reconstruction. If the tumor was located in a limited part of the epiphysis, partial resection of the epiphysis was performed to preserve the healthy part of the cartilage in 4 cases. The survival of grafted frozen cartilage was assessed by X-ray imaging. The end point was defined as grade IV of the Kellgren and Lawrence osteoarthritis grading system and was recorded using the Kaplan–Meier method. In case of removal of grafted bone after the surgery, pathological findings were assessed by hematoxylin and eosin staining of sections of resected cartilage in available cases to observe the fate of grafted cartilage over time.
Result: The postoperative mean follow-up period was 94.0 months. Grade IV osteoarthritis occurred in 12 patients. All patients in the partial epiphyseal freezing group survived compared with only 1 patient in the total epiphyseal freezing group who had survived to the final follow up (p < 0.01). Resected specimens with grafted cartilage were examined histologically. A sample excised after 14 months had dead cartilage with empty lacunae and the surface of the cartilage had reactive fibrous tissue.
Conclusion: Grafted cartilage of frozen osteoarticular autografts was worn out over time. However, intraepiphyseal resection preserving partial healthy cartilage resulted in excellent survival. This technique requires careful planning of the surgery but might be an alternative to megaprosthesis.
Haploidentical Related Donor versus Matched Sibling Donor Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia and Myelodysplastic Syndrome Aged Over 50 Years: A Single-Center Retrospective Study.
Authors: Huang Jiafu , Huang Fen , Fan Zhiping , Xu Na , Xuan Li , Liu Hui , Shi Pengcheng , Jiang Ling , Zhang Yu , Sun Jing , Liu Qifa
Published: October 2019

BACKGROUND Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative therapeutic option for patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). Increasing data supports the utility of haploidentical related donor (HID) HSCT in fit older patients and resulting in improvement of outcomes. This study compared the outcomes of acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) patients age ≥50 years underwent haploidentical related donor (HID) or matched sibling donor (MSD) allogeneic hematopoietic stem cell transplantation (allo-HSCT).METHODS We provided HID transplantation to 38 patients of AML/MDS age ≥50 years and compared their outcomes with 55 patients of the same ages who underwent matched sibling donor (MSD) transplantation.RESULTS The 100-day cumulative incidence of II-IV° acute graft-versus-host disease (GVHD) were 34.2 ± 7.7% and 23.6 ± 5.7%, respectively, in HID and MSD groups (P = 0.189), and III-IV° acute GVHD were similar between two groups (5.3% and 7.3%, respectively, P=0.700). The 2-year cumulative incidence of limited and extensive chronic GVHD was not statistically different in HID and MSD groups(22.8 ± 10.8% vs. 18.2 ± 6.0% and 18.3 ± 10.4% vs. 22.1 ± 6.8%, P = 0.890 and P=0.424, respectively). The 2-year cumulative incidences of relapse (29.5±10.3% and 20.7 ±6.1%, P=0.458), 2-year overall survival (58.5±9.7% and 67.9±6.8%, P=0.373), 2-year transplant-related mortality (17.3±6.4% and 15.0±5.3%, P=0.717), 2-year progression free survival (56.8±9.7% and 64.6±7.4%, P=0.312) were similar in the two groups.CONCLUSION We conclude that HID allo-SCT is feasible and safe for elderly AML/MDS patients.
Synergistic effect of low doses of Chlorhexidine and Clotrimazole against Candida spp.
Authors: Feng Shijun , Li Huarui , Ai Dongfang , Yan Hua , Zhang Guangjing , Wang Zhengxiang , Ma Jing
Published: October 2019

Objectives Systemic diseases or oral situation changes can result in oral infections like candidiasis. Mouthwash is the most prevalent method to prevent or cure these infections. To formulate a more effective mouthwash, we combined Clotrimazole with a low dose of Chlorhexidine to investigate the in vitro effect against Candida spp.Methods and Materials Combinations of Chlorhexidine (0.03-16ug/ml) and Clotrimazole (0.03-16ug/ml) were tested against Candida spp. by microdilution chequerboard technique and disk diffusion method.Results From the chequerboard combination assay, the MICs of Chlorhexidine and Clotrimazole against Candida spp. decreased from >16µg/ml to 2–1µg/ml and from 2-0.25µg/ml to 0.5–0.125µg/ml, respectively, demonstrating favorable synergistic effects against 21 (84%) strains of Candida spp. The disk diffusion method showed an increase in halo size for the combination group when compared to the Clotrimazole alone group.Conclusions Studies have shown that combinations of antiseptic and antifungal agents are effective in nature. In our study, we found that low concentrations of Chlorhexidine can enhance the antifungal effect of Clotrimazole against Candida spp.. We predict that the mechanism of this synergism could be due to the increased penetration of Clotrimazole brought about by the binding of Chlorhexidine to the cell membrane. Further studies to determine the mechanism and in vivo effects could increase its probable usage in clinical studies.
A hybrid hydraulic model for gradual transition from intermittent to continuous water supply in Amman, Jordan: a theoretical study
Authors: El Achi Nassim , Rouse Michael J.
Published: October 2019

Intermittent water supply (IWS) is associated with numerous negative consequences with respect to health and access along with technical impacts that aggravate the sustainable supply of water, thus rendering Sustainable Development Goal 6.1 (SDG 6.1) hardly achievable. The gradual, or zone-by-zone, transition from IWS to continuous water supply is very effective in terms of economic scarcity. This work focused on designing a theoretical ‘hybrid’ hydraulic model where both types of services, intermittent and continuous, were included in the modelling. The preliminary, not calibrated model, which was applied in a district in Amman, has shown to be efficient on both the technical and economic sides as it achieves independent district metering areas. Sustainable access to water, however, necessitates an integrated solution taking into account the technical, economic, social and psychological factors along with the modelling aspect highlighted in this work.
Comparative iTRAQ Proteomic Analysis Provides the Molecular Basis of the Metabolites in Cultivated Glycyrrhiza uralensis and its Wild-Type
Authors: Wang Chengcheng , Chen Lihong , Cai Zhichen , Feng Sijing , Yue Moyi , Yang Jiaojiao , Zou Lisi , Liu Xunhong
Published: October 2019

Background:

Licorice is an herbal medicine applied extensively worldwide, and most of the
licorice for clinical consumption is provided by Glycyrrhiza uralensis Fisch. Evidence suggests that
there is a significant difference in the metabolite composition of licorice from different ecotypes.

Objective:

To better understand the proteomic changes and molecular mechanisms of metabolite formation
in wild and cultivated Glycyrrhiza uralensis Fisch.

Methods:

Firstly, we established a proteome database by annotating protein sequences according to the
genomic and transcriptomic data of G. uralensis. Then, iTRAQ and LC-MS/MS were applied to detect
significant protein changes between cultivated and wild G. uralensis. A total of 2751 validated proteins
were obtained with high confidence, and 333 were differentially expressed. Differentially expressed
proteins were identified and analysed by GO, KEGG, and STRING for network and pathway enrichment.
Ultimately, we combined the iTRAQ results with our previous investigation on metabolites to
understand the molecular mechanisms underlying metabolite accumulation.

Results:

The results showed that differentially expressed proteins were mainly involved in the anabolism
of carbohydrates and important amino acids that participate in primary metabolism and secondary
metabolite synthesis. Another important pathway is the synthesis of flavonoids, which are generally accepted
as important bioactive constituents of G. uralensis, and the accumulation of flavonoids in different
synthesis stages in two ecotypes of G. uralensis was diverse. Therefore, the differentially abundant proteins
in wild and cultivated G. uralensis possibly resulted in differences in medicinal compounds.

Conclusion:

Our study will provide novel clues for revealing the molecular mechanism of secondary
metabolite synthesis as well as quality formation in wild and cultivated G. uralensis.
Design, Synthesis and Biological Evaluation of 3-(3,4,5-Trimethoxyphenyl)- 5-(2-(5-arylbenzo[b]thiophen-3-yl)oxazol-5-yl)isoxazole Derivatives as Anticancer Agents
Authors: Premalatha Syndla , Rambabu G. , Hatti Islavathu , Ramachandran Dittakavi
Published: October 2019

A new series of 3-(3,4,5-trimethoxyphenyl)-5-(2-(5-arylbenzo[b]thiophen-3-yl)oxa zol-5-
yl)isoxazole derivatives were designed and synthesized. All these derivatives were evaluated for their
anticancer activity against various human cancer cell lines such as MCF-7 (breast cancer), A549 (lung
cancer), DU-145 (prostate cancer) and MDA MB-231 (breast cancer)-four human cancer cell lines by
using MTT assay. Here, etoposide was used as a standard reference drug and most of the compounds
were exhibited good anticancer activity with respect to cell lines. Among all compounds, five compounds
11b, 11c, 11f, 11i and 11j showed more potent activity than standard drug, in which, compound
11f was the most promising compound.
Integrative Analysis of Whole-genome Expression Profiling and Regulatory Network Identifies Novel Biomarkers for Insulin Resistance in Leptin Receptor-deficient Mice
Authors: Zhang Yuchi , Wu Xinyu , Zhao Cong , Li Kai , Zheng Yi , Zhao Jing , Ge Pengling
Published: October 2019

Background:

Molecular characterization of insulin resistance, a growing health issue
worldwide, will help to develop novel strategies and accurate biomarkers for disease diagnosis and
treatment.

Objective:

Integrative analysis of gene expression profiling and gene regulatory network was exploited
to identify potential biomarkers early in the development of insulin resistance.

Methods:

RNA was isolated from livers of animals at three weeks of age, and whole-genome expression
profiling was performed and analyzed with Agilent mouse 4×44K microarrays. Differentially
expressed genes were subsequently validated by qRT-PCR. Functional characterizations of
genes and their interactions were performed by Gene Ontology (GO) analysis and gene regulatory
network (GRN) analysis.

Results:

A total of 197 genes were found to be differentially expressed by fold
change ≥2 and P < 0.05 in BKS-db +/+ mice relative to sex and age-matched controls. Functional
analysis suggested that these differentially expressed genes were enriched in the regulation of
phosphorylation and generation of precursor metabolites which are closely associated with insulin
resistance. Then a gene regulatory network associated with insulin resistance (IRGRN) was constructed
by integration of these differentially expressed genes and known human protein-protein
interaction network. The principal component analysis demonstrated that 67 genes in IRGRN
could clearly distinguish insulin resistance from the non-disease state. Some of these candidate
genes were further experimentally validated by qRT-PCR, highlighting the predictive role as biomarkers
in insulin resistance.

Conclusions:

Our study provides new insight into the pathogenesis and treatment of insulin resistance
and also reveals potential novel molecular targets and diagnostic biomarkers for insulin resistance.
Dairy Safety Prediction Based on Machine Learning Combined with Chemicals
Authors: Chen Jiahui , Zhou Guangya , Xie Jiayang , Wang Minjia , Ding Yanting , Chen Shuxian , Xia Sijing , Deng Xiaojun , Chen Qin , Niu Bing
Published: October 2019

Background:

Dairy safety has caused widespread concern in society. Unsafe dairy
products have threatened people's health and lives. In order to improve the safety of dairy products
and effectively prevent the occurrence of dairy insecurity, countries have established different prevention
and control measures and safety warnings.

Objective:

The purpose of this study is to establish a dairy safety prediction model based on machine
learning to determine whether the dairy products are qualified.

Methods:

The 34 common items in the dairy sampling inspection were used as features in this
study. Feature selection was performed on the data to obtain a better subset of features, and different
algorithms were applied to construct the classification model.

Results:

The results show that the prediction model constructed by using a subset of features including
“total plate”, “water” and “nitrate” is superior. The SN, SP and ACC of the model were
62.50%, 91.67% and 72.22%, respectively. It was found that the accuracy of the model established
by the integrated algorithm is higher than that by the non-integrated algorithm.

Conclusion:

This study provides a new method for assessing dairy safety. It helps to improve the
quality of dairy products, ensure the safety of dairy products, and reduce the risk of dairy safety.
Comprehensive Review on Model Predictive Control Applied to Power Electronics
Authors: Alam Mahetab , Ahmad Shahbaz , Anees M. Anas , Tariq Mohd. , Azeem Abdul
Published: October 2019

Model Predictive Control (MPC) in the field of power electronics has recently gained a
lot of interest in the research community. Even though the computations are very complex in MPC
algorithm, the availability of powerful processors has helped this approach to acquire a notable
place in the area of control. They can take into account the nonlinearities and constraints very precisely.
Having these advantages, they are found to be very attractive for controlling power converters
and drives. This paper presents the review of growth and applications of MPC applied to power
converters and drives. Some of the key elements like prediction model and its discretization, cost
function, weighing factor and optimization algorithm are highlighted in this paper.
Total-dose Effects on Power MOSFET in SEPIC Converter for Nanosatellite Applications
Authors: Krishnamurthy Saranya , Kannan Ramani , Mohamad Faidhi F.A. , Ahmad Muhamad S. , Abdullah Yusof
Published: October 2019

Background:

Power converters used in nanosatellite application required to be more tolerant
to radiations including proton, electron and heavy-ion radiation.

Methods:

A Single-Ended Primary Inductance Converter (SEPIC) is selected for the nanosatellite
application because of the availability to step up and down the input voltage as well as having a
non-inverting polarity between the input and output voltage. In this paper, remodeled SEPIC converter
proposed with an improved performance at radiation environment to work for nanosatellite
application. In addition, the analysis is carried out for the irradiated power MOSFET in SEPIC converter
to check its impact on converter behavior.

Results:

Experiments conducted with the help of power MOSFET switch used in converter, irradiated
with Cobalt60 gamma ray dose level from 50krad to 300krad and output characteristics analyzed
by chancing the duty cycle of converter. Investigations shown that conventional converter
output characteristics were virtually constant from 10% to 60% duty cycle when different radiated
MOSFETs used in the converter.

Conclusion:

The electrical characteristics started to fluctuate at 60% duty cycle and onwards, while
the remodeled converter circuit was less distorted when increasing the radiation dose.
The Multi-step Transformation Control and Exponentially Stability for Linear Discrete-time Systems with Additional Control Delay
Authors: Zhu Qixin , Liu Hongli , Zhu Yonghong
Published: October 2019

Background:

Few results about the controller of linear discrete-time system with control
delay are reported.

Methods:

By means of the multi-step transformation with memory, the linear discrete-time systems
with additional control delay can be transformed to the equivalent linear discrete-time systems without
control delay, and the dimension of the transformed system is not increased. By designing the
optimal controller of the finite horizon optimal controller of linear discrete time systems without
time delay, the controller of linear discrete time systems with additional control delay can be obtained.
At the same time, by designing the optimal controller of the infinite horizon optimal controller
of linear discrete time systems without time delay, the controller of linear discrete time systems
with additional control delay can be obtained as well.

Results:

The corresponding finite horizon optimal controller has proved to render the closed-loop
system exponentially stable. And the corresponding infinite horizon optimal controller has proved to
render the closed-loop system exponentially stable when the open-loop system is either controllable
or stabilizable. Finally, two examples are used to verify the theoretical results of this paper.

Conclusion:

The controller design and the exponentially stability of discrete-time linear system
with additional state delay will be investigated in the future.
Dari Pengobatan ke Pergerakan: Nasionalisme dan Kebangkitan Dokter-Dokter Indonesia dalam Merawat Bangsa
Authors: Moordiati Moordiati
Published: October 2019

Profesi dokter bukan lagi hanya terikat dan terbatas pada persoalan medis dan kesehatan semata, tetapi para dokter juga mampu berperan aktif dalam pengambilan keputusan dan pergerakan politik suatu bangsa. Dokter-dokter di Indonesia telah membuktikan itu dalam perjalanan sejarah bangsa. Mereka aktif merawat bangsanya melalui semangat pergerakan dan kebangsaan (Nasionalisme).
Prevalencia de factores y estratificación de riesgo cardiovascular en personal que labora en una unidad de medicina familiar
Authors: Zavala Rubio Juan de Dios , Rivera Montellano María Luisa , Sánchez Martínez Saúl , De la Mata Márquez Miriam Judith , Torres Rodríguez María Mirta
Published: October 2019

Objetivo: determinar la prevalencia de factores y estratificación del riesgo cardiovascular (rcv) en personal que labora en la Unidad de Medicina Familiar (umf) no. 24 de Ciudad Mante, Tamaulipas, México. Métodos: estudio transversal, muestreo no probabilístico, participaron trabajadores del Instituto Mexicano del Seguro Social (imss) que acudieron a valoración anual en los Servicios de Prevención y Promoción de la Salud para Trabajadores imss (sppstimss); se evaluaron 85 trabajadores adscritos a la umf no. 24. Criterios de inclusión: trabajadores mayores de dieciocho años, ambos sexos, cualquier categoría laboral. Se evaluaron variables de edad, género, categoría laboral, medidas antropométricas, antecedentes familiares y personales, niveles séricos de glucosa y perfil de lípidos; se aplicó la escala de Framingham para determinar rcv global. Resultados: del total de trabajadores, 65 pertenecían al sexo femenino (76.4%), la edad promedio fue de 39.4 años. La hipertensión arterial estuvo presente en seis trabajadores (8.2%); nueve presentaron diabetes mellitus tipo 2 (dm2) (10.5%) y uno, cardiopatía (1.1%); 66 presentaron algún grado de sobrepeso u obesidad (76.4%). El riesgo cardiovascular global con base en la escala Framingham fue bajo en 76 participantes (89.4%), moderado en ocho (9.4%) y alto en uno (1.1%). Conclusiones: el rcv global calculado fue bajo para la mayoría de trabajadores, sin embargo, la prevalencia de factores de riesgo cardiovascular (frcv) del personal se mostró elevado; se requieren implementar estrategias educativas en promoción de la salud en el lugar de trabajo para disminuir la prevalencia de dichos factores.
Impacto de una estrategia educativa sobre salud sexual y reproductiva en adolescentes de una escuela secundaria
Authors: Cadena Téllez Claudia Adriana , Martini Blanquel Haydee Alejandra
Published: October 2019

Objetivo: evaluar el impacto de una estrategia educativa participativa en el conocimiento que tienen los adolescentes de una escuela secundaria sobre salud sexual y reproductiva. Métodos: estudio cuasiexperimental en un grupo de 37 alumnos de tercer año de una escuela secundaria pública de la Ciudad de México, durante el mes de mayo de 2017; se construyó y validó un instrumento que midió el conocimiento en salud sexual y reproductiva. Posterior a una prueba premuestreo, se calculó su confiabilidad con la prueba alfa de Cronbach y se utilizó la prueba U de Mann Whitney para comparar las dos mitades del instrumento (semipartición) y corroborar si existía o no diferencia entre ellas. La estrategia educativa tuvo una duración de tres días y cada actividad constó de tres fases: 1) actividad previa, 2) trabajo y discusión en subgrupos y 3) sesión plenaria. El instrumento se aplicó antes y después de la estrategia educativa participativa y se compararon los resultados con la prueba de McNemar. Resultados: el coeficiente de confiabilidad del instrumento fue de 0.7; al comparar sus dos mitades, no se encontró diferencia estadísticamente significativa entre ellas (p= 0.06). 40.5% de participantes obtuvo un conocimiento alto antes de la estrategia (n= 15) y 72.9% posterior a ésta (n=27), con una diferencia estadísticamente significativa (p < 0.001). Conclusión: la estrategia educativa participativa resultó ser útil, esto puede ser de gran ayuda para que los adolescentes elaboren su propio conocimiento sobre salud sexual y reproductiva, y en consecuencia lo puedan aplicar en su vida cotidiana.