bluuebunny/crossref_metadata_2025 huggingface dataset:
Obstetrical and Perinatal Outcomes Are Not Associated with Advanced Paternal Age in IVF or ICSI Pregnancies with Autologous Oocytes
Authors: Navarro-Gomezlechon Ana , Gil Juliá María , Pacheco-Rendón Rosa María , Hervás Irene , Mossetti Laura , Rivera-Egea Rocío , Garrido Nicolás
Published: September 2023

Background: In recent years, there has been an evident delay in childbearing and concerns have been raised about whether this increase in age affects reproductive outcomes. This study aimed to evaluate the effect of paternal age on obstetrical and perinatal outcomes in couples undergoing in vitro fertilization or intracytoplasmic sperm injection using autologous sperm and oocytes. Methods: This retrospective study evaluated obstetrical and perinatal outcomes from 14,125 couples that were arbitrarily divided into three groups according to paternal age at conception: ≤30 (n = 1164), 31–40 (n = 11,668) and >40 (n = 1293). Statistics consisted of a descriptive analysis followed by univariate and multivariate models, using the youngest age group as a reference. Results: The study showed significantly longer pregnancies for the fathers aged 31–40 compared to ≤30 years. However, there were no significant differences for the type of delivery, gestational diabetes, anaemia, hypertension, delivery threat, premature rupture of membranes, preterm birth, very preterm birth, and the neonate’s sex, weight, low birth weight, very low birth weight, length, cranial perimeter, Apgar score and neonatal intensive care unit admission. Conclusion: Despite our promising results for older fathers, as paternal age was not associated with clinically relevant obstetrical and perinatal outcomes, future well-designed studies are necessary as it has been associated with other important disorders.
Mitochondrial Calcium Overload Plays a Causal Role in Oxidative Stress in the Failing Heart
Authors: Dridi Haikel , Santulli Gaetano , Bahlouli Laith , Miotto Marco C. , Weninger Gunnar , Marks Andrew R.
Published: September 2023

Heart failure is a serious global health challenge, affecting more than 6.2 million people in the United States and is projected to reach over 8 million by 2030. Independent of etiology, failing hearts share common features, including defective calcium (Ca2+) handling, mitochondrial Ca2+ overload, and oxidative stress. In cardiomyocytes, Ca2+ not only regulates excitation–contraction coupling, but also mitochondrial metabolism and oxidative stress signaling, thereby controlling the function and actual destiny of the cell. Understanding the mechanisms of mitochondrial Ca2+ uptake and the molecular pathways involved in the regulation of increased mitochondrial Ca2+ influx is an ongoing challenge in order to identify novel therapeutic targets to alleviate the burden of heart failure. In this review, we discuss the mechanisms underlying altered mitochondrial Ca2+ handling in heart failure and the potential therapeutic strategies.
The Influence of Beverages on Resin Composites: An In Vitro Study
Authors: Gradinaru Irina , Vasiliu Ana Lavinia , Bargan Alexandra , Checherita Laura Elisabeta , Ciubotaru Bianca-Iulia , Armencia Adina Oana , Istrate Bogdan , Dascalu Cristina Gena , Antohe Magda Ecaterina
Published: September 2023

Dental composites, through their structural diversity, represent the biomaterials frequently used in dental reconstructive therapy. The aim of our study was to observe the influence of different beverage environment conditions on seven types of obturation dental materials with different compositions. Our research focused on the surface modification analysis of the materials after the immersion in the different beverages; in this regard, we used the EDAX technique correlated with the energy-dispersive X-ray fluorescence (XRF). The pH of the drinks and that of the simulated saliva solution were determined by the titrimetric method, a sodium hydroxide solution 0.1 mol/dm3 was prepared and used for the titration. An amount of 5 mL of each analyzed solution was added to 15 mL of distilled water to obtain a dilution, to which 3 drops of phenolphthalein (as a color indicator—Phenolphthalein, 3,3-Bis(4-hydroxyphenyl)-1(3H)-isobenzofuranone, C20H14O4 Mw: 318.32, purchased from Merck) were added for each analysis. For each solution, the experiment was repeated three times in order to obtain accurate results. The results of our study materialized into a real plea for modifying the patients’ behavior in terms of diet and preferences for acidic drinks, so that their quality-of-life valence can be improved by keeping the composite materials in a long-term unalterable state on the one hand; on the other hand, systemic damage can be prevented as well.
High-Dose Vitamin B6 (Pyridoxine) Displays Strong Anti-Inflammatory Properties in Lipopolysaccharide-Stimulated Monocytes
Authors: Mikkelsen Kathleen , Dargahi Narges , Fraser Sarah , Apostolopoulos Vasso
Published: September 2023

Vitamin B6 is shown to have anti-inflammatory properties, which makes it an interesting nutraceutical agent. Vitamin B6 deficiency is well established as a contributor to inflammatory-related conditions, whilst B6 supplementation can reverse these inflammatory effects. There is less information available regarding the effects of high-dose vitamin B6 supplementation as a therapeutic agent. This study set out to examine the effects of high-dose vitamin B6 on an LPS-stimulated monocyte/macrophage cell population via an analysis of protein and gene expression using an RT2 profiler PCR array for Human Innate and Adaptive Immune responses. It was identified that high-dose vitamin B6 has a global anti-inflammatory effect on lipopolysaccharide-induced inflammation in monocyte/macrophage cells by downregulating the key broad-spectrum inflammatory mediators CCL2, CCL5, CXCL2, CXCL8, CXCL10, CCR4, CCR5, CXCR3, IL-1β, IL-5, IL-6, IL-10, IL-18, IL-23-a, TNF-α, CSF2, DDX58, NLRP3, NOD1, NOD2, TLR-1 -2 -4 -5 -7 -8 -9, MYD88, C3, FOXP3, STAT1, STAT3, STAT6, LYZ, CASP-1, CD4, HLA-E, MAPK1, MAPK8 MPO, MX-1, NF-κβ, NF-κβ1A, CD14, CD40, CD40LG, CD86, Ly96, ICAM1, IRF3, ITGAM, and IFCAM2. The outcomes of this study show promise regarding vitamin B6 within the context of a potent broad-spectrum anti-inflammatory mediator and could prove useful as an adjunct treatment for inflammatory-related diseases.
Insights into the Fabrication and Electrochemical Aspects of Paper Microfluidics-Based Biosensor Module
Authors: Kumari Rohini , Singh Akanksha , Azad Uday Pratap , Chandra Pranjal
Published: September 2023

Over the past ten years, microfluidic paper-based analytical devices (micro-PADs) have attracted a lot of attention as a viable analytical platform. It is expanding as a result of advances in manufacturing processes and device integration. Conventional microfluidics approaches have some drawbacks, including high costs, lengthy evaluation times, complicated fabrication, and the necessity of experienced employees. Hence, it is extremely important to construct a detection system that is quick, affordable, portable, and efficient. Nowadays, micro-PADs are frequently employed, particularly in electrochemical analyses, to replicate the classic standard laboratory experiments on a miniature paper chip. It has benefits like rapid assessment, small sample consumption, quick reaction, accuracy, and multiplex function. The goal of this review is to examine modern paper microfluidics-based electrochemical sensing devices for the detection of macromolecules, small molecules, and cells in a variety of real samples. The design and fabrication of micro-PADs using conventional and the latest techniques have also been discussed in detail. Lastly, the limitations and potential of these analytical platforms are examined in order to shed light on future research.
An Updated Review on Electrochemical Nanobiosensors for Neurotransmitter Detection
Authors: Choi Hye Kyu , Choi Jin-Ha , Yoon Jinho
Published: September 2023

Neurotransmitters are chemical compounds released by nerve cells, including neurons, astrocytes, and oligodendrocytes, that play an essential role in the transmission of signals in living organisms, particularly in the central nervous system, and they also perform roles in realizing the function and maintaining the state of each organ in the body. The dysregulation of neurotransmitters can cause neurological disorders. This highlights the significance of precise neurotransmitter monitoring to allow early diagnosis and treatment. This review provides a complete multidisciplinary examination of electrochemical biosensors integrating nanomaterials and nanotechnologies in order to achieve the accurate detection and monitoring of neurotransmitters. We introduce extensively researched neurotransmitters and their respective functions in biological beings. Subsequently, electrochemical biosensors are classified based on methodologies employed for direct detection, encompassing the recently documented cell-based electrochemical monitoring systems. These methods involve the detection of neurotransmitters in neuronal cells in vitro, the identification of neurotransmitters emitted by stem cells, and the in vivo monitoring of neurotransmitters. The incorporation of nanomaterials and nanotechnologies into electrochemical biosensors has the potential to assist in the timely detection and management of neurological disorders. This study provides significant insights for researchers and clinicians regarding precise neurotransmitter monitoring and its implications regarding numerous biological applications.
Specific Tumor Localization of Immunogenic Lipid-Coated Mesoporous Silica Nanoparticles following Intraperitoneal Administration in a Mouse Model of Serous Epithelial Ovarian Cancer
Authors: Noureddine Achraf , Marwedel Benjamin , Tang Lien , Medina Lorel Y. , Serda Rita E.
Published: September 2023

Immunogenic lipid-coated mesoporous silica nanoparticles (ILM) present pathogen-associated molecular patterns (PAMPs) on the nanoparticle surface to engage pathogen-associated receptors on immune cells. The mesoporous core is capable of loading additional immunogens, antigens or drugs. In this study, the impact of lipid composition, surface potential and intercalation of lipophilic monophosphoryl lipid A (MPL-A) in the lipid coat on nanoparticle properties and cellular interactions is presented. Loading and retention of the model antigen ovalbumin into the mesoporous silica core were found to be similar for all nanoparticle formulations, with presentation of ova peptide (SIINFEKL) by major histocompatibility complex (MHC) evaluated to facilitate the selection of an anionic nanoparticle composition. ILM were able to induce lysosomal tubulation and streaming of lysosomes towards the cell surface in dendritic cells, leading to an enhanced surface presentation of MHC. Myeloid cells robustly internalized all ILM formulations; however, non-myeloid cells selectively internalized cationic ILM in vitro in the presence of 20% serum. Interestingly, ILM administration to the peritoneal cavity of mice with disseminated ovarian cancer resulted in selective accumulation of ILM in tumor-associated tissues (>80%), regardless of nanoparticle surface charge or the presence of MPL-A. Immunofluorescence analysis of the omental tumor showed that ILMs, regardless of surface charge, were localized within clusters of CD11b+ myeloid cells 24 h post administration. Selective uptake of ILMs by myeloid cells in vivo indicates that these cells outcompete other cell populations in the ovarian tumor microenvironment, making them a strong target for therapeutic interventions.
Neo-Adjuvant Treatment in Primary Resectable Pancreatic Cancer: A Systematic Review and PRISMA-Compliant Updated Metanalysis of Oncological Outcomes
Authors: Roesel Raffaello , Deantonio Letizia , Bernardi Lorenzo , Garo Maria Luisa , Majno-Hurst Pietro , Vannelli Alberto , Cefalì Marco , Palmarocchi Maria Celeste , Valli Maria Carla , Pesola Guido , Cristaudi Alessandra , De Dosso Sara
Published: September 2023

Background: Despite advances in treatment, the prognosis of resectable pancreatic adenocarcinoma remains poor. Neoadjuvant therapy (NAT) has gained great interest in hopes of improving survival. However, the results of available studies based on different treatment approaches, such as chemotherapy and chemoradiotherapy, showed contrasting results. The aim of this systematic review and meta-analysis is to clarify the benefit of NAT compared to upfront surgery (US) in primarily resectable pancreatic adenocarcinoma. Methods: A PRISMA literature review identified 139 studies, of which 15 were finally included in the systematic review and meta-analysis. All data from eligible articles was summarized in a systematic summary and then used for the meta-analysis. Specifically, we used HR for OS and DFS and risk estimates (odds ratios) for the R0 resection rate and the N+ rate. The risk of bias was correctly assessed according to the nature of the studies included. Results: From the pooled HRs, OS for NAT patients was better, with an HR for death of 0.80 (95% CI: 0.72–0.90) at a significance level of less than 1%. In the sub-group analysis, no difference was found between patients treated with chemoradiotherapy or chemotherapy exclusively. The meta-analysis of seven studies that reported DFS for NAT resulted in a pooled HR for progression of 0.66 (95% CI: 0.56–0.79) with a significance level of less than 1%. A significantly lower risk of positive lymph nodes (OR: 0.45; 95% CI: 0.32–0.63) and an improved R0 resection rate (OR: 1.70; 95% CI: 1.23–2.36) were also found in patients treated with NAT, despite high heterogeneity. Conclusions: NAT is associated with improved survival for patients with resectable pancreatic adenocarcinoma; however, the optimal treatment strategy has yet to be defined, and further studies are required.
Cytology and HPV Co-Testing for Detection of Vaginal Intraepithelial Neoplasia: A Retrospective Study
Authors: Stuebs Frederik A. , Dietl Anna K. , Koch Martin C. , Adler Werner , Geppert Carol Immanuel , Hartmann Arndt , Knöll Antje , Mehlhorn Grit , Beckmann Matthias W. , Schulmeyer Carla E. , Heindl Felix , Emons Julius , Seibold Anja , Behrens Annika S. , Gass Paul
Published: September 2023

(1) Background: Vaginal intraepithelial neoplasia (VaIN) is a rare premalignant disease caused by persistent human papillomavirus (HPV) infection. Diagnosing VaIN is challenging; abnormal cytology and positive HPV tests are usually the first signs, but published data on their accuracy for detecting it are rare and contradictory. The aim of this study is to compare the results of hrHPV and cytology co-testing with the histological findings of the vagina. (2) Methods: In the certified Dysplasia Unit at Erlangen University Hospital, cytology and HPV samples from the uterine cervix or vaginal wall after hysterectomy were obtained between 2015 and 2023 and correlated with histological findings in biopsies from the vaginal wall. Women without vaginal biopsy findings or concomitant cervical disease were excluded. (3) Results: In all, 279 colposcopies in 209 women were included. The histological results were: benign (n = 86), VaIN I/vLSIL (n = 116), VaIN II/vHSIL (n = 41), VaIN III/vHSIL (n = 33), and carcinoma (n = 3). Accuracy for detecting VaIN was higher in women with previous hysterectomies. Positive HPV testing during colposcopy increased the likelihood for VaIN II/III/vHSIL threefold. The detection rate for VaIN III/vHSIL was 50% after hysterectomy and 36.4% without hysterectomy. (4) Conclusions: Women with risk factors for VaIN, including HPV-16 infection or prior HPV-related disease, need careful work-up of the entire vaginal wall. Hysterectomy for HPV-related disease and a history of cervical intraepithelial neoplasia (CIN) also increased the risk for VaIN II/III/vHSIL.
Unraveling the Role of Hepatic PGC1α in Breast Cancer Invasion: A New Target for Therapeutic Intervention?
Authors: Ganesan Kumar , Xu Cong , Liu Qingqing , Sui Yue , Chen Jianping
Published: September 2023

Breast cancer (BC) is the most common cancer among women worldwide and the main cause of cancer deaths in women. Metabolic components are key risk factors for the development of non-alcoholic fatty liver disease (NAFLD), which may promote BC. Studies have reported that increasing PGC1α levels increases mitochondrial biogenesis, thereby increasing cell proliferation and metastasis. Moreover, the PGC1α/ERRα axis is a crucial regulator of cellular metabolism in various tissues, including BC. However, it remains unclear whether NAFLD is closely associated with the risk of BC. Therefore, the present study aimed to determine whether hepatic PGC1α promotes BC cell invasion via ERRα. Various assays, including ELISA, western blotting, and immunoprecipitation, have been employed to explore these mechanisms. According to the KM plot and TCGA data, elevated PGC1α expression was highly associated with a shorter overall survival time in patients with BC. High concentrations of palmitic acid (PA) promoted PGC1α expression, lipogenesis, and inflammatory processes in hepatocytes. Conditioned medium obtained from PA-treated hepatocytes significantly increased BC cell proliferation. Similarly, recombinant PGC1α in E0771 and MCF7 cells promoted cell proliferation, migration, and invasion in vitro. However, silencing PGC1α in both BC cell lines resulted in a decrease in this trend. As determined by immunoprecipitation assay, PCG1a interacted with ERRα, thereby facilitating the proliferation of BC cells. This outcome recognizes the importance of further investigations in exploring the full potential of hepatic PGC1α as a prognostic marker for BC development.
Mutant Cytochrome C as a Potential Detector of Superoxide Generation: Effect of Mutations on the Function and Properties
Authors: Chertkova Rita V. , Oleynikov Ilya P. , Pakhomov Alexey A. , Sudakov Roman V. , Orlov Victor N. , Semenova Marina A. , Arutyunyan Alexander M. , Ptushenko Vasily V. , Kirpichnikov Mikhail P. , Dolgikh Dmitry A. , Vygodina Tatiana V.
Published: September 2023

Cytochrome c (CytC) is a single-electron carrier between complex bc1 and cytochrome c-oxidase (CcO) in the electron transport chain (ETC). It is also known as a good radical scavenger but its participation in electron flow through the ETC makes it impossible to use CytC as a radical sensor. To solve this problem, a series of mutants were constructed with substitutions of Lys residues in the universal binding site (UBS) which interact electrostatically with negatively charged Asp and Glu residues at the binding sites of CytC partners, bc1 complex and CcO. The aim of this study was to select a mutant that had lost its function as an electron carrier in the ETC, retaining the structure and ability to quench radicals. It was shown that a mutant CytC with substitutions of five (8Mut) and four (5Mut) Lys residues in the UBS was almost inactive toward CcO. However, all mutant proteins kept their antioxidant activity sufficiently with respect to the superoxide radical. Mutations shifted the dipole moment of the CytC molecule due to seriously changed electrostatics on the surface of the protein. In addition, a decrease in the redox potential of the protein as revealed by the redox titrations of 8Mut was detected. Nevertheless, the CD spectrum and dynamic light scattering suggested no significant changes in the secondary structure or aggregation of the molecules of CytC 8Mut. Thus, a variant 8Mut with multiple mutations in the UBS which lost its ability to electron transfer and saved most of its physico-chemical properties can be effectively used as a detector of superoxide generation both in mitochondria and in other systems.
High Thermal Stability of Enzyme-MOF Composites at 180 °C
Authors: Cui Shitong , Ge Jun
Published: September 2023

Encapsulating enzymes in a tailored scaffold is of great potential in industrial enzymatic catalysis, which can enhance the stability of enzymes thus expanding their applications. Metal–organic frameworks (MOFs) are emerging as promising candidates for enzyme encapsulation due to their precise pore structure, ease of synthesis and good biocompatibility. Despite the fact that enzymes encapsulated in MOFs can obtain enhanced stability, there has been little discussion about the thermal stability of enzyme-MOF composites in solid state under extremely high temperatures. Herein, we fabricated the enzyme-MOF composites, CALB-ZIF-8, via a convenient coprecipitation method in aqueous solution, which exhibited good thermal stability at 180 °C. It was found that the activity of CALB encapsulated in ZIF-8 retained nearly ~80% after heating for 10 min at 180 °C. A finite element method was applied to investigate the heat transfer process within a ZIF-8 model, indicating that the air filled in cavities of ZIF-8 played a significant role in hindering the heat transfer and this may be an important reason for the outstanding thermal stability of CALB-ZIF-8 at 180 °C, which paves a new path for expanding the industrial application of enzyme-MOF composites.
Prenatal Workshops and Support Groups for Prospective Parents Whose Children Will Need Neonatal Care at Birth: A Feasibility and Pilot Study
Authors: Boutillier Béatrice , Ethier Guillaume , Boucoiran Isabelle , Reichherzer Martin , Luu Thuy Mai , Morin Lucie , Pearce Rebecca , Janvier Annie
Published: September 2023

Introduction: Support groups in neonatal intensive care units (NICUs) are beneficial to parents. The usefulness of prenatal support groups for prospective parents who will have a newborn requiring admission to the NICU has never been investigated. Methods: We assessed the needs of NICU parents regarding topics they would have wished to discuss prenatally and developed the content of a prenatal support workshop. A standardized survey prospectively evaluated the perspectives of pregnant women admitted to a high-risk pregnancy unit who participated in the resulting workshops. Results: During needs assessment, 295 parents invoked themes they would have wished to discuss antenatally: parental guilt, future parental role, normalizing their experience/emotions, coping with many losses, adapting to their new reality, control and trust, information about the NICU, technology around the baby, common neonatal interventions, the NICU clinical team, and the role of parents in the team. These findings were used to develop the workshop, including a moderator checklist and a visual presentation. Practical aspects of the meetings were tested/finalized during a pre-pilot phase. Among 21 pregnant women who answered the survey (average gestational age 29.3 weeks), all agreed that the workshop was useful, that it made them feel less lonely (95%), that exchanges with other women were beneficial (95%) and gave them a certain amount of control over their situation (89%). All answers to open-ended questions were positive. Conclusion: Prenatal educational/support workshops provide a unique and useful means to support future NICU parents. Future investigations will explore whether these prenatal interventions improve clinical outcomes.
p62 Is a Potential Biomarker for Risk of Malignant Transformation of Oral Potentially Malignant Disorders (OPMDs)
Authors: Takasaki Ryo , Uchida Fumihiko , Takaoka Shohei , Ishii Ryota , Fukuzawa Satoshi , Warabi Eiji , Ishibashi-Kanno Naomi , Yamagata Kenji , Bukawa Hiroki , Yanagawa Toru
Published: September 2023

To determine the intracellular behavior of p62, a marker of selective autophagy, in oral potentially malignant disorders (OPMDs). This retrospective study includes 70 patients who underwent biopsy or surgical resection and were definitively diagnosed with OPMDs. Immunohistochemical staining for p62, XPO1, p53, and ki67 was performed on all samples and positive cell occupancy was calculated. We statistically investigated the correlation between protein expression in OPMDs and the association between malignant transformation, clinicopathological characteristics, and occupancy. ki67 expression was negatively correlated with p62 expression in the nucleus (p < 0.01) and positively correlated with p62 expression in the cytoplasm (p < 0.01). For malignant transformation, the expression of p62 in the nucleus (p = 0.03) was significantly lower in malignant transformation cases, whereas the expression of p62 in the cytoplasm (p = 0.03) and the aggregation expression (p < 0.01) were significantly higher. Our results suggest that the function of p62 is altered by its subcellular localization. In addition, defects in selective autophagy occur in cases of malignant transformation, suggesting that p62 is a potential biomarker of the risk of malignant transformation of OPMDs.
Influence of Microstructure on Tensile Properties and Fatigue Crack Propagation Behavior for Lath Martensitic Steel
Authors: Deng Yongjie , Liang Yilong , Zhao Fei , Xu Fahong , Yang Ming , Long Shaolei
Published: September 2023

This paper addresses the role of multilevel microstructures on the fatigue crack propagation behavior and the tensile properties of lath martensite with different substructure sizes. Microstructure characterization of the alloy was carried out by transmission electron microscopy (TEM), scanning electron microscopy (SEM), electron back-scattering diffraction (EBSD), and optical microscopy (OM). Based on the classic Hall–Petch relationship, the results of tensile tests showed that martensitic block is the effective control unit of yield strength. Furthermore, the plasticity of lath martensite is not sensitive to grain size. The tensile deformation mechanisms were also discussed. Fatigue crack propagation tests revealed that the coarse grain has a higher crack propagation threshold and lower crack propagation rate than the fine grain in lath martensitic steel. The change in the plasticity zone ahead of the crack tip leads to the transitional behavior of the fatigue crack propagation rate. When plasticity zone sizes are equal to the block size, the fatigue crack propagation reverts to a stable propagation stage. Finally, an empirical model was established to predict the fatigue crack propagation rate of the stable propagation stage based on the tensile properties of the lath martensitic steel.
Enhancement in the Capillary Performance of Aluminum Groove through Laser Textured Deposition
Authors: Lou Deyuan , Chen Pengjian , Jiang Hongliang , Yang Dongchao , Yang Qibiao , Tao Qing , Liu Dun
Published: September 2023

Groove is widely used in the wicks of heat pipes. In this paper, a laser texture deposition (LTD) process was proposed to texture deposit SiO2 in rectangular aluminum groove. Both the SEM and XPS analysis revealed that a fluffy SiO2 layer was deposited on the surface of alumina fluff, which increased the fluff density. Statistically, the density of fluff on the surface of LTD was 1.12 times higher than that on the laser texture (LT) surface, leading to an increase in porosity and decrease in effective capillary radius. This significantly improved the capillary performance of the LTD groove. The results showed that, compared to the Raw and LTD grooves, the increase in height of the LTD groove was enhanced by 2.42 and 1.07 times, respectively, in 5 s, while the capillary performance factor (M) was increased by 2.83 and 1.04 times, respectively, in 1 s. This study introduces a novel process for enhancing the capillary performance of aluminum groove.
Prioritizing Solutions and Improving Resources among Young Pediatric Brain Tumor Survivors: Results of an Online Survey
Authors: Bonanno Marco , Bourque Claude Julie , Robichaud Lye-Ann , Levesque Ariane , Lacoste-Julien Ariane , Rondeau Émélie , Dubé Émilie , Leblanc Michelle , Bertrand Marie-Claude , Provost Carole , Desjardins Leandra , Sultan Serge
Published: September 2023

Pediatric Brain Tumor Survivors (PBTS) often experience social, academic and employment difficulties during aftercare. Despite their needs, they often do not use the services available to them. Following a previous qualitative study, we formulated solutions to help support PBTS return to daily activities after treatment completion. The present study aims to confirm and prioritize these solutions with a larger sample. We used a mixed-methods survey with 68 participants (43 survivors, 25 parents, PBTS’ age: 15–39 years). Firstly, we collected information about health condition, and school/work experience in aftercare. Then, we asked participants to prioritize the previously identified solutions using Likert scales and open-ended questions. We used descriptive and inferential statistics to analyze data, and qualitative information to support participants’ responses. Participants prioritized the need for evaluation, counseling, and follow-up by health professionals to better understand their post-treatment needs, obtain help to access adapted services, and receive information about resources at school/work. Responses to open-ended questions highlighted major challenges regarding the implementation of professionals’ recommendations at school/work and the need for timely interventions. These results will help refine solutions for PBTS and provide key elements for future implementation. Translating these priorities into action will need further work involving professionals and decision makers.
A New Odd Beta Prime-Burr X Distribution with Applications to Petroleum Rock Sample Data and COVID-19 Mortality Rate
Authors: Suleiman Ahmad Abubakar , Daud Hanita , Singh Narinderjit Singh Sawaran , Ishaq Aliyu Ismail , Othman Mahmod
Published: September 2023

In this article, we pioneer a new Burr X distribution using the odd beta prime generalized (OBP-G) family of distributions called the OBP-Burr X (OBPBX) distribution. The density function of this model is symmetric, left-skewed, right-skewed, and reversed-J, while the hazard function is monotonically increasing, decreasing, bathtub, and N-shaped, making it suitable for modeling skewed data and failure rates. Various statistical properties of the new model are obtained, such as moments, moment-generating function, entropies, quantile function, and limit behavior. The maximum-likelihood-estimation procedure is utilized to determine the parameters of the model. A Monte Carlo simulation study is implemented to ascertain the efficiency of maximum-likelihood estimators. The findings demonstrate the empirical application and flexibility of the OBPBX distribution, as showcased through its analysis of petroleum rock samples and COVID-19 mortality data, along with its superior performance compared to well-known extended versions of the Burr X distribution. We anticipate that the new distribution will attract a wider readership and provide a vital tool for modeling various phenomena in different domains.
Nonlinear Fokker–Planck Equations, H-Theorem and Generalized Entropy of a Composed System
Authors: Evangelista Luiz R. , Lenzi Ervin K.
Published: September 2023

We investigate the dynamics of a system composed of two different subsystems when subjected to different nonlinear Fokker–Planck equations by considering the H–theorem. We use the H–theorem to obtain the conditions required to establish a suitable dependence for the system’s interaction that agrees with the thermodynamics law when the nonlinearity in these equations is the same. In this framework, we also consider different dynamical aspects of each subsystem and investigate a possible expression for the entropy of the composite system.
The Algorithm for Assessing the Effects of Distance Education in General Education on Students’ Academic Results
Authors: Gaidelys Vaidas , Čiutienė Rūta , Cibulskas Gintautas , Baliute Asta
Published: September 2023

Distance education has gained great interest during the COVID-19 pandemic, when schools all over the world faced the challenge of transferring the traditional education processes to digital platforms. In this context, school communities not only discovered the new opportunities, but also encountered a number of problems when trying to provide high quality distance education and minimise learning losses for students. The rapid transition to distance education has had a negative impact on the academic results and daily routines of the students from all social groups, especially socially vulnerable families. Thus, it has become relevant to research various aspects of students’ learning losses. The purpose of this article is to theoretically substantiate the algorithm intended for assessing the effects of distance education on students’ academic results. The research was based on the methods of scientific literature analysis, secondary data analysis, theoretical modelling, inductive content analysis, and expert evaluation. The algorithm is intended for general education institutions. Results: After conducting scientific literature and secondary data analysis, the theoretical model for assessing the effects of distance education on students’ academic results was developed and substantiated. The model consists of four structural parts, represented by 11 criteria, which reveal the effects of distance education in general education following the appropriate algorithm.
Teacher Learning towards Equitable Mathematics Classrooms: Reframing Problems of Practice
Authors: Solomon Yvette , Eriksen Elisabeta , Bjerke Annette Hessen
Published: September 2023

This study responds to the debate on understanding and evaluating teacher learning in professional development programmes, with particular reference to the development of equitable mathematics classrooms. Conducted in the context of a year-long PD mathematics programme for primary teachers in Norway, designed to disrupt teachers’ assumptions about mathematics pedagogy and how it relates to students’ mathematical thinking, this study takes teachers’ entry goals as its point of departure. Sixteen teachers participated in interviews at the end of the course. Recognising the situated nature of the development of pedagogic judgement in our analysis of teachers’ reflections on their learning, we report on the shift in their “problems of practice” towards actionable concerns about student inclusion. We argue that this shift underpins a fundamental change in their assumptions about teaching and learning and a critical stance towards their own professional practice, suggesting an important indicator of what constitutes sustainable professional development for critical mathematics education.
The Distributed HTAP Architecture for Real-Time Analysis and Updating of Point Cloud Data
Authors: Kim Juhyun , Moon Changjoo
Published: September 2023

Updating the most recent set of point cloud data is critical in autonomous driving environments. However, existing systems for point cloud data management often fail to ensure real-time updates or encounter situations in which data cannot be effectively refreshed. To address these challenges, this study proposes a distributed hybrid transactional/analytical processing architecture designed for the efficient management and real-time processing of point cloud data. The proposed architecture leverages both columnar and row-based tables, enabling it to handle the substantial workloads associated with its hybrid architecture. The construction of this architecture as a distributed database cluster ensures real-time online analytical process query performance through query parallelization. A dissimilarity analysis algorithm for point cloud data, built by utilizing the capabilities of the spatial database, updates the point cloud data for the relevant area whenever the online analytical process query results indicate high dissimilarity. This research contributes to ensuring real-time hybrid transactional/analytical processing workload processing in dynamic road environments, helping autonomous vehicles generate safe, optimized routes.
Analysis of Onshore Synthetic Inertia and Primary Control Reserve Contributions of Alternating Current-Side Meshed Offshore Grids with Voltage-Source Converter and Diode Rectifier Unit High-Voltage Direct Current Connections
Authors: Herrmann Michael , Alkemper Merlin , Hofmann Lutz
Published: September 2023

The increasing use of renewable energy sources in place of conventional generation units is leading to a reduction in onshore inertia and to the development of offshore wind park grids connected by multiple high-voltage direct current (HVDC) connections to the onshore alternating current (AC) grid. For AC-side meshed offshore grids with voltage-source converter (VSC) and diode rectifier unit (DRU) HVDC connections towards onshore grids, this study focuses on the energetic feasibility of synthetic inertia (SI) and primary control reserve (PCR) contributions triggered locally at the onshore converters of both connection types. To this end, the obstacles preventing contributions for VSC HVDC connections and the mechanisms allowing contributions for DRU HVDC connections are identified first. Based on these findings, the article proposes an enhancement of the offshore HVDC converter controls that is continuously active and allows locally triggered onshore contributions at all onshore HVDC converters of both connection types without using communication and requiring only minimal system knowledge. Additional simulations confirm that, although the enhancement is continuously active, the operational performance of the offshore HVDC converter controls for normal offshore grid operation and its robustness against offshore AC-side faults are not affected.
Investigation of Cooling Techniques for Roof-Mounted Silicon Photovoltaic Panels in the Climate of the UAE: A Computational and Experimental Study
Authors: Abdelaty Tarek , Chaudhry Hassam Nasarullah , Calautit John Kaiser
Published: September 2023

The increased adoption of photovoltaic (PV) systems for global decarbonisation necessitates addressing the gap in reduced panel efficiency due to overheating. This issue is especially prominent in countries with extremely hot and humid climates where PV utilisation is hindered by declining panel output. A systematic review of PV cooling techniques suggests passive systems are more economical, sustainable, and easier to implement than active systems, despite possessing a lower cooling potential. Air-based systems were deemed the most viable for the UAE’s climate, considering both performance and cost. Based on these findings, two individual improvements for air-based cooling systems were combined in an attempt to achieve greater cooling: a segmented multiangular aluminium fin heatsink developed from previous works. Various perforation patterns were simulated on the chosen heatsink using CFD software to determine the most optimal arrangement. The original and optimised models were both tested under real-life conditions in Dubai, United Arab Emirates, revealing similar cooling potential between the two. The results of this study indicate that the PV cell temperature can be decreased by up to 10 °C with the placement of an aluminium fin heatsink, which corresponds to an approximate efficiency increase of 5%.
Review, Comprehensive Analysis and Derivation of Analytical Power Loss Calculation Equations for Two- to Three-Level Midpoint Clamped Inverter Topologies with Hybrid Switch Configurations
Authors: Radomsky Lukas , Mallwitz Regine
Published: September 2023

Increased performance requirements in new power electronics areas of application, such as electric aircraft, make innovations on different design levels necessary. In order to quickly compare different topologies, analytical loss equations provide a fast and straightforward way to narrow down the possible solution space. The approach widely used in the literature results in long and complex terms, which can only be compared between different literature sources with great effort. Moreover, the literature lacks a detailed summarizing description of these analytical equations and their derivation, starting from the standard two-level VSI up to three-level midpoint clamped inverter topologies, such as the ANPC topology in its different modulation schemes. The application of such higher-level inverter topologies allows hybrid device configurations to become performant solutions. This work aims to give a closed-form description of the analytical loss modeling and the theoretical background and provide an implementation approach for a wide span of inverter topologies and for different modulation methods.
Structuring Nutrient Yields throughout Mississippi/Atchafalaya River Basin Using Machine Learning Approaches
Authors: Zhen Yi , Feng Huan , Yoo Shinjae
Published: September 2023

To minimize the eutrophication pressure along the Gulf of Mexico or reduce the size of the hypoxic zone in the Gulf of Mexico, it is important to understand the underlying temporal and spatial variations and correlations in excess nutrient loads, which are strongly associated with the formation of hypoxia. This study’s objective was to reveal and visualize structures in high-dimensional datasets of nutrient yield distributions throughout the Mississippi/Atchafalaya River Basin (MARB). For this purpose, the annual mean nutrient concentrations were collected from thirty-three US Geological Survey (USGS) water stations scattered in the upper and lower MARB from 1996 to 2020. Eight surface water quality indicators were selected to make comparisons among water stations along the MARB over the past two decades. Principal component analysis (PCA) was used to comprehensively evaluate the nutrient yields across thirty-three USGS monitoring stations and identify the major contributing nutrient loads. The results showed that all samples could be analyzed using two main components, which accounted for 81.6% of the total variance. The PCA results showed that yields of orthophosphate (OP), silica (SI), nitrate–nitrites (NO3-NO2), and total suspended sediment (TSS) are major contributors to nutrient yields. It also showed that land-planted crops, density of population, domestic and industrial discharges, and precipitation are fundamental causes of excess nutrient loads in MARB. These factors are of great significance for the excess nutrient load management and pollution control of the Mississippi River. It was found that the average nutrient yields were stable within the sub-MARB area, but the large nitrogen yields in the upper MARB and the large phosphorus yields in the lower MARB were of great concern. t-distributed stochastic neighbor embedding (t-SNE) revealed interesting nonlinear and local structures in nutrient yield distributions. Clustering analysis (CA) showed the detailed development of similarities in the nutrient yield distribution. Moreover, PCA, t-SNE, and CA showed consistent clustering results. This study demonstrated that the integration of dimension reduction techniques, PCA, and t-SNE with CA techniques in machine learning are effective tools for the visualization of the structures of the correlations in high-dimensional datasets of nutrient yields and provide a comprehensive understanding of the correlations in the distributions of nutrient loads across the MARB.
Study on the Limit of Moisture Content of the Sub-Surface Fires Converted to the Surface Fires in the Boreal Forests of China
Authors: Shan Yanlong , Chen Xiang , Yin Sainan , Cao Lili , Tang Shuyuan , Yu Bo , Cui Chenxi
Published: September 2023

A sub-surface forest fire is a type of smoldering combustion with a slower spread rate, longer combustion time, and lower combustion temperature compared with flame combustion. Sub-surface fires are usually accompanied by surface fires, and the surface fires’ conversion from sub-surface fires has great uncertainty. Therefore, there are considerable difficulties in monitoring and fighting sub-surface fires. However, there are few studies on the conversion from sub-surface fires to surface fires, and the mechanism and influencing factors of the conversion remain unclear. This study focuses on Larix gmelinii forests, which are representative of the boreal forest of China and hot spots of sub-surface fires, studies the moisture content limit of sub-surface fires’ conversion to surface fires by simulating a smoldering experiment, and establishes a monitoring model of sub-surface fires and an occurrence probability prediction model of sub-surface fires’ conversion to surface fires. The results showed that the moisture content limit of the conversion was 25% in the grass–Larix gmelinii forest and Ledum palustre–Larix gmelinii forest and 20% in Rhododendron dauricum–Larix gmelinii forest. There was a significant positive correlation between the time and temperature caused by the smoldering. The monitoring model of the sub-surface fires based on the surface temperature and moisture content had a good fitting effect (p < 0.01). The occurrence probability prediction model of the sub-surface fires’ conversion to surface fires, based on a logistic regression model, had high prediction accuracy (AUC = 0.987). The lower the moisture content of the humus, the closer the smoldering came to the surface and the higher the probability of conversion. This research could contribute to the study of the mechanism of sub-surface fires’ conversion into surface fires.
Innovative Approaches to Fungal Food Production: Mycelial Pellet Morphology Insights
Authors: Cheng Chih-Yu , Wang Yu-Sheng , Wang Zhong-Liang , Bibi Sidra
Published: September 2023

Mycelia products enhance edible mushrooms in alignment with future sustainability trends. To meet forthcoming market demands, the morphology of mycelial pellets was optimized for direct consumption. Among ten commercial edible mushrooms in Taiwan, Pleurotus sp. was selected for its rapid growth and was identified via an internal transcribed spacer sequence. A combination of Plackett-Burman design and Taguchi’s L9(34) orthogonal table revealed the optimal formula as potato dextrose broth (2.4%), olive oil (2%), calcium carbonate (0.5%), yeast extract (0.75%), and soy flour (0.5%). This led to a biomass increase to 19.9 ± 1.1 g/L, resulting in a 2.17-fold yield increase. To refine morphology, image processing by ImageJ quantified spherical characteristics. The addition of 0.2 to 1.0% Tween 80 enhanced pellet compaction by over 50%. Dilution of the medium improved uniformity (0.85) and conversion rate (42%), yielding mycelial pellets with 2.10 ± 0.52 mm diameters and a yield of 15.1 ± 0.6 g/L. These findings provide an alternative evaluation and application of edible mycelial pellets as future food.
A Study on the Formation of Flavor Substances by Bacterial Diversity in the Fermentation Process of Canned Bamboo Shoots in Clear Water
Authors: Li Ke , Gao Ning , Tang Jiaojiao , Ma Huiqin , Jiang Jiayan , Duan Yufan , Li Zongjun
Published: September 2023

Canned bamboo shoots in clear water could produce a unique flavor through bacterial diversity via the fermentation process. Weissella, Streptococcus, Leuconostoc, Acinetobacter, Lactococcus and Lactobacillus were the main microorganisms. Tyrosine was the most abundant free amino acid (FAA), which had a negative correlation with Lactococcus. Ten kinds of flavor substances, such as 3-methyl-1-butanol, acetic acid, 2-phenylethyl ester, benzene acetaldehyde, benzoic acid and ethyl ester, were important influential factors in the flavor of fermented bamboo shoots. Through the verification test of tyrosine and phenylalanine decarboxylase, it was found that Lactococcus lactis TJJ2 could decompose tyrosine and phenylalanine to produce benzaldehyde and benzene acetaldehyde, which provided the fermented bamboo shoots with a grassy aroma.