bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluasi Waktu Optimal pada Pekerjaan Pembangunan Jalan (Studi Kasus Proyek Pembangunan Jalan Wisata Mangrove Desa Galanti Kecamatan Wolowa Kabupaten Buton)
Authors: Bahar Syamsul Bahri
Published: September 2023

Tujuan penelitian ini untuk mengetahui evaluasi waktu optimal pada pekerjaan pembangunan jalan wisata Desa Mangrove Desa Galanta Kecamatan Wolowa Kabupaten Buton. Jalan Wisata Mangrove Desa Galanti Kecamatan Wolowa Kabupaten Buton Provinsi Sulawesi Tenggara, merupakan transportasi jalan raya yang memegang peranan penting dalam pembangunan dan pengembangan suatu wilayah guna memperlancar hubungan suatu wilayah, daerah dengan daerah sekitarnya. Jalan Wisata yang dibangun pada anggaran tahun 2020. Pelaksanaan proyek pembangunan jalan untuk mencapai tujuan yang telah ditetapkan tahapan perencanaan, pelaksanaan, dan pengendalian merupakan salah satu tindakan yang dilakukan. Dalam pelaksanaannya proyek ini sering mengalami keterlambatan akibat faktor eksternal seperti cuaca yang buruk, lokasi/ area proyek yang buruk dan mobilisasi yang lambat. Proyek yang awalnya dikerjakan selama 90 hari kalender akibat terjadinya keterlambatan menjadi 120 hari kalender. Berdasarkan data yang terkumpul serta hasil analisis kuantitatif dengan metode bina marga ditemukan waktu optimal untuk menyelesaikan pekerjaan Jalan Wisata Mangrove Desa Galanti, Kecamatan Wolowa, Kabupaten Buton selama 111 hari kalender.
Analisis Status Gizi, Siklus Menstruasi, dan Konsumsi Rokok Elektrik terhadap Nyeri Dismenorea pada Wanita Usia Subur
Authors: Kusumastuti Nurry Ayuningtyas , Suarsih Acih
Published: September 2023

Nyeri saat menstruasi sering menimbulkan ketidaknyamanan pada wanita, bahkan terganggunya aktifitas sehari-hari. Kandungan rokok dapat menyebabkan ketidakseimbangan hormone yang akan berpengaruh terhadap dismenorea. Faktor risiko lainnya yang berkontribusi dalam terjadinya dismenorea, yaitu periode menstruasi dan kegemukan. Tujuan penelitian ini adalah menganalisis hubungan status gizi, siklus menstruasi, dan konsumsi rokok elektrik terhadap nyeri dismenore pada wanita usia subur. Desain penelitian ini adalah kuantitatif dengan pendekatan cross sectional. Populasi dalam penelitian ini adalah seluruh wanita usia subur di vape store wilayah kecamatan Karawaci, Tangerang. Sampel dalam penelitian ini sebanyak 100 responden dengan menggunakan teknik accidental sampling yang dilakukan selama 2 minggu. Instrumen penelitian ini menggunakan kuesioner untuk variabel independennya, yaitu status gizi, siklus menstruasi, dan konsumsi rokok elektrik. Variabel dependennya, yaitu nyeri dismenore menggunakan NRS (numeric rating scale). Hasil penelitian ini adalah nilai p-value status gizi terhadap nyeri dismenore sebesar 0.012, siklus menstruasi terhadap nyeri dismenore sebesar 0.000, dan konsumsi rokok elektrik terhadap nyeri dismenore sebesar 0.008. Kesimpulan Terdapat hubungan status gizi, siklus menstruasi, dan konsumsi rokok elektrik terhadap nyeri dismenore.
The Widening of European Union to Post Soviet Countries: Case Study of Bulgaria Acceptance and Ukraine Accession
Authors: Pulungan Eska Dwipayana
Published: September 2023

To be a part of European Union must follow complex procedures. Before joining the institution, candidate countries must meet the Copenhagen Criteria. Then fulfill membership obligations contained in Acquis Communautaire. Once fulfilled, candidate countries can join the institution. However, in contrast to Bulgaria, Bulgaria was unable to fulfill it, but was given the easiness by providing CVM assistance. Bulgaria's acceptance was considered violate the EU agreement, making several members disappointed, especially UK. The peak of UK disappointment occurred in 2016, the UK stated its exit from the EU. Then in 2022, Ukraine in the midst of the Russian invasion applying to join. Without an in-depth administrative review, EU agreed to immediately grant candidate State status. Necessarily, a country which is applying EU, First should be on the waiting list with the status of a potential candidate countries and then second go to next status as a candidate countries, the last is recognize as a member of union. But Ukraine directly jump up to second status.
Technical Barrier dalam GATT/WTO Studi terhadap Larangan Ekspor Rokok Kretek Indonesia ke Amerika
Authors: Melina Monika , Admiral Admiral
Published: September 2023

Perlakuan yang berbeda dalam perdagangan atas barang yang sejenis dapat menimbulkan ketidakadilan, hal ini tentunya tidak sejalan dengan prinsip yang disepakati oleh negara anggota WTO yaitu suatu perdagangan bebas serta kompetisi yang adil, namun ada beberapa pengecualiaan yang mana salah satunya WTO masih mengijinkan negara anggotanya untuk melakukan pembatasan perdagangan dengan beberapa alasan yang mana telah diatur dalam Technical Barrier to Trade yang mana dapat mengaburkan kompetisi yang adil dalam perdagangan Internasional. Hasil dari penelitian ini menunjukan ketentuan The Family Smoking Prevention and Tobacco Control Act (FSPTCA) tahun 2009 yang dikeluarkan oleh AS dinilai melindungi produk domestik negaranya sendiri dan juga dianggap telah melakukan diskriminasi terhadap produksi rokok kretek. Hal ini tentunya melanggar prinsip Non Discrimination dan National Treatment yang disepakati dan ada didalam GATT dan juga TBT pada umumnya. Hambatan teknis yang diperbolehkan melalui kebijakan tarif yang diperbolehkan untuk suatu negara melakukan proteksi dengan alasan tarif jika dianggap rasional dan dapat diprediksi. Selain pengenaan tarif, Penggunaan kebijakan non-tarif seperti Kuota juga diperbolehkan dengan alasan-alasan yang tercantum pada pasal XX GATT mengenai pengecualiaan umum (geberal exception). Namun penggunaan pasal tersebut tidak boleh dilakukan begitu saja melainkan harus mengikuti dasar hukum yang ada.
Ketersediaan dan Kebutuhan Air Daerah Irigasi Ameroro Kabupaten Konawe
Authors: Haydir Haydir , Ega Abdul Aman , Saputra Iksan , Sukri Ahmad Syarif , Hasddin Hasddin
Published: September 2023

In general, sources of agricultural irrigation in Indonesia still rely on rainwater, so the productivity of wetland agriculture, especially rice, is highly dependent on rainwater as an agricultural input. In this position, irrigation (weirs) is important in maintaining the availability of water for agricultural irrigation needs. This study aims to analyze water availability and water demand from Ameroro Irrigation. Both of these results provide information (pattern) of farmer planting. Research data comes from primary and secondary. Comparative analysis of the supply and demand for irrigation water using the Penman method and the F.J. Mock method to determine the amount of water flow from rainfall data, the hydrological characteristics of the catchment area, and evapotranspiration. The results of this study position that the construction of the Ameroro Dam has a vital role in maintaining the balance of irrigation (inflow and outflow). Maintaining this balance is at the same time the basis for irrigation engineering management efforts for agricultural activities. For farmers, those who live on or cultivate functional agricultural land A, B, and C start the planting season in May or in another month taking into account that the maximum plant growth period does not occur in the October period.
Eksistensi Hukum Adat Mosehe Masyarakat Tolaki pada Penyelesaian Perkawinan di Desa Woiha, Kolaka Timur
Authors: Haerani Yeni , Dedihasriadi La Ode , Patmasari Patmasari , Nurcahyo Edy
Published: September 2023

Mosehe is a symbol or symbol that expresses the conception of the Tolaki tribe, both to humans, the universe and the relationship between humans and other humans. Mosehe is divided into two, namely Mosehemohewu and Moseheowose or Mosehewonua. Mosehemohewu is held in a simple form, namely if there is conflict between humans, both individuals within the family, and between families. The author's focus is Mosehe in the simple form of conflict between individual humans in the family (marital problems). The research method used is empirical legal research. The data used is data that is directly obtained from data sources in the field (field research) and then described. The existence and role of Mosehe in solving problems in marriage in Woiha Village, Tirawuta District, East Kolaka Regency is very important, where the Mosehe ceremony is not only a sacred activity but is also believed to reject all dangers or repel reinforcements. Plays an important role in solving various problems in marital problems, such as elopement, pregnancy out of wedlock and other marital problems, because in the symbol of the mosehe ceremony it is symbolized as an act of purification from all sins/mistakes.
Batalnya Sertifikat Merek yang Dijadikan Agunan Kredit dalam Bentuk Jaminan Fidusia
Authors: Wijayanti Ana Wahyu
Published: September 2023

Penelitian ini bertujuan untuk mengetahui akibat hukum dari pembatalan sertifikat merek yang dijadikan objek jaminan fidusia dan pengaruhnya terhadap kreditur yang bertindak sebagai penerima jaminan. Strategi penelitian yang dipilih penulis adalah strategi penelitian hukum normatif. Dalam artikel ini akan dibahas standar hukum yang mengatur tentang merek dagang dan jaminan fidusia. Persoalan hukum yang akan datang, khususnya jika pihak yang berkepentingan mengajukan gugatan untuk menuntut haknya atas merek yang menjadi obyek jaminan fidusia dalam suatu perjanjian kredit, yang mengakibatkan pencabutan sertifikat merek dan penghapusan merek tersebut dari daftar umum merek dan dibuat tidak dapat dioperasikan. Pendekatan penelitian hukum normatif digunakan oleh penulis untuk mencari solusi dari permasalahan tersebut. Metodologi analisis hukum kualitatif digunakan dalam pekerjaan ini. Mempertimbangkan pendapat dan prinsip otoritas hukum sehubungan dengan masalah hukum yang tercakup dalam pasal ini. Sesuai Undang-Undang Nomor 24 Tahun 2019 tentang Ekonomi Kreatif, Pemerintah mendukung rencana pendanaan berbasis kekayaan intelektual bagi Pelaku Ekonomi Kreatif. Merek dapat dijadikan jaminan utang untuk mendapatkan fasilitas pembiayaan dari lembaga keuangan karena dianggap sebagai Kekayaan Intelektual dengan Nilai Ekonomi Tinggi. Namun, pihak yang berkepentingan masih memiliki opsi untuk membatalkan merek terdaftar.
Pengaruh Terpaan Informasi Dari Unggahan Akun Gosip @Playitsaferbaby Terhadap Tingkat Kepercayaan Followers
Authors: Fadia Alfiansha Zahra , Ismail Oki Achmad
Published: September 2023

Penelitian ini bertujuan untuk mengetahui apakah informasi dari unggahan akun gosip Playitsaferbaby masih mendapatkan kepercayaan atau tidak dari followers-nya. Penelitian ini akan menggunakan teori dependensi efek komunikasi massa. Teori ini beranggapan bahwa jika tuntutan informasional yang tidak dapat dipenuhi melalui pengalaman langsung dapat terpenuhi, maka kepercayaan individu terhadap media akan terus meningkat. Peneliti memilih jenis penelitian dengan menggunakan metode kuantitatif. Penelitian akan dilakukan melalui survei dalam bentuk kuesioner. Pengumpulan data didasarkan oleh hasil responden kuisioner terhadap pertanyaan yang telah diajukan oleh peneliti. Hasil pengujian koefisien determinasi, didapatkan nilai R square sebesar 36,6%. Hal ini menunjukan bahwa terpaan informasi akun gossip @playitsaferbaby berpengaruh sebesar 36,6% terhadap tingkat kepercayaan followers. Pada uji hipotesis, didapatkan nilai t hitung sebesar 7.515 dengan tingkat signifikasi sebesar 0,05%. Dikarenakan nilai t hitung > t tabel (7,515 > 1,660), hal tersebut membuktikan bahwa terdapat pengaruh terapaan informasi dari unggahan akun gosip @playitsaferbaby berpengaruh signifikan terhadap tingkat kepercayaan followers.
Sports Marketing Dalam Menarik Minat Penonton Formula E di Indonesia
Authors: Alfario Reinaldo , Kuswoyo Chandra
Published: September 2023

This research was conducted to test and find out the influence of sports marketing (sports advertising, star athletes, and sports sponsorship) in attracting Formula E spectators in Indonesia. Quantitative approach is the technique used in this study. Data collection was carried out by distributing online questionnaires and a total of 135 respondents were obtained. Data was collected using an online survey. After being created using the Google Form, the questionnaire was distributed to the Indonesian people online. Questionnaire measurements were carried out using a Likert scale, where 1 indicated strongly disagree and 5 indicated strongly agreed. Testing is done by testing the instrument, namely testing the validity and reliability of the questionnaire. The analysis technique used is multiple regression analysis. The research findings found that there is a simultaneous effect of sports advertising, star athlete, and sports sponsorship variables on audience interest. Meanwhile, based on partial research results, the elements of sports marketing that influence audience interest are sports advertising and star athletes. Sports sponsorship does not have a significant influence in attracting audience interest.
Kajian Etnokuliner Tradisional Suku Melayu di Kabupaten Mempawah dan Analisis Potensi Ekonominya
Authors: Syamsuri Syamsuri
Published: September 2023

Etnokuliner adalah olahan pangan tradisional oleh suatu suku atau etnis, yang sifatnya turun temurun dan menjadi indigenous knowledge di wilayah tersebut. Tujuan penelitian ini yaitu menginventarisir olahan pangan tradisional suku Melayu di Kabupaten Mempawah  dan menganalisis potensi ekonominya untuk mengetahui peluang wirausaha dari olahan pangan tersebut. Implikasi penelitian ini diharapkan dapat menambah informasi pengetahuan yang sifatnya ilmiah mengenai jenis pangan tradisional yang memiliki potensi wirausaha khususnya olahan pangan tradisional Suku Melayu di Kabupaten Mempawah. Metode penelitian untuk menginventarisir jenis olahan pangan tradisional yaitu menggunakan teknik Participatory Rural Appraisal (PRA), melalui observasi dan wawancara terhadap narasumber. Responden penelitian yaitu masyarakat Melayu di Kabupaten Mempawah, sedangkan responden kunci yang digunakan yaitu ketua adat dan masyarakat yang ahli mengolah masakan tradisional Melayu. Data empiris yang diperoleh selanjutnya dicatat dan disajikan dalam bentuk tabel, kemudian dianalisis secara deksriptif, sedangkan potensi ekonomi untuk menentukan peluang wirausahanya dianalisis menggunakan rumus penerimaan dan pendapatan. Hasil penelitian menunjukkan bahwa jenis olahan pangan tradisional Suku Melayu di Kabupaten Mempawah yaitu kerupuk basah, bubur pedas, pengkang, sotong pangkong, patlau, lemang, mie sagu, bingke berendam dan tempoyak. Analisa potensi ekonomi diperoleh bahwa penerimaan total tiap jenis olahan pangan tersebut lebih besar dibandingkan biaya operasional atau biaya pembuatannya
Komunikasi Interpersonal antara Guru dengan Anak Penyandang Tunarungu dalam Menyampaikan Ajaran Agama Islam di SLB Daarus Salam Kabupaten Asahan
Authors: Sibarani Zordy Andrean , Simamora Irma Yusriani
Published: September 2023

Penelitian ini bertujuan untuk menggali informasi mengenai komunikasi interpersonal siswa tunarungu dalam pembelajaran Agama Islam. Metode yang digunakan yaitu kualitatif deskriptif. Informan penelitian yaitu guru dan anak murid. Menggunakan tehni pengumpulan data yaitu wawancara dan observasi dan dokumentasi. Lokasi penelitian tunarungu di daarus salam kabupaten asahan. Teknik analisis data yang digunakan yakni pengumpulan data, reduksi data, dispalay data dan verifikasi data. Teknik keabsahan data menggunakan trigulasi sumber, tehnik dan waktu. Hasil penelitian menunjukkan bahwa siswa tunarungu membutuhkan pendekatan komunikasi interpersonal yang berbeda dengan siswa normal, termasuk dalam pembelajaran Agama Islam. Guru-guru tersebut mengaplikasikan beberapa teknik dan metode komunikasi interpersonal seperti penggunaan bahasa isyarat, tulisan, gambar, dan media visual untuk membantu siswa tunarungu memahami konsep Agama Islam. Selain itu, mereka juga berkolaborasi dengan orang tua peserta didik. Kesimpulan sangat penting peranan guru dalam berkomunikasi interpersonal dengan siswanya dimana disebabkan dengan berkomunikasi dengan baik maka akan mudah siswa atau guru memahami apa yang mereka sampaikan atau bicarakan.
Analysis Company Value based Good Corporate Governance on Financial Performance in the Service Trade and Investment Sector on the Indonesian Stock Exchange 2020-2022
Authors: Azaluddin Azaluddin
Published: September 2023

The purpose of this study was to examine the effect of financial performance, as measured by return on equity (ROE), on firm value by including good corporate governance (GCG) as a moderator. The study used a sample of eight companies listed on the Indonesia Stock Exchange (IDX). Information about company revenues, one of the information included in financial reports, is used as a focal point because information about company revenues can be used to assess management performance and responsibilities with a total of 32 observations. The data collection method used in this study reads, records and records monthly reports for 2021-2022 related to downloading data and information on companies in the trade, services and investment sectors listed on the Indonesian Stock Exchange. The results of this study indicate that financial performance has a positive impact on goodwill. The results of this study indicate that the value of Indonesian companies, especially those engaged in the trade and investment services sector, is determined by the earning power of company assets, and the higher the earning power, the more efficient the turnover of assets and funds is displayed.
Development of Digital Literacy on Role of the Instagram Platform in Elementary School Students
Authors: Manan Manan , Yurfiah Yurfiah , Nuraini Nuraini , Verdianto Verdianto , Kamasiah Kamasiah
Published: September 2023

The purpose of this study is to describe the role of the Instagram platform in increasing digital literacy among grade IV students at Elementary School Country 2 Wameo. Researchers used a qualitative descriptive research method.  The subjects of this study were 25 grade IV students. This study uses instruments in collecting data, namely: observation, interviews, and documentation. The data analysis techniques used include: (1) Data reduction (2) Data presentation (3) Conclusion. The results of the study show the role of the Instagram platform in increasin students digital literacy in class IV Elementary School Country 2 Wameo creating interest in students as well as teachers and students being more creative in using technology, making use of up to date learning resources, students' skills in using new media, students obtaining a variety of relevant information. more broadly, and students have experience from the internet so they can improve students' digital literacy skills by fulfilling competencies in the form of technical abilities, critical understanding, and the ability to communicate and participate.
Analisis Keragaan Usaha Tahu di Industri Rumah Tangga Dwi Berkah Kabupaten Buton
Authors: Purnamasari Wa Ode Dian , Al Zarliani Wa Ode , Wabula Fikri Haykal
Published: September 2023

Keragaan atau kinerja industri rumah tangga ditunjukkan dengan kemampuan produsen mengelola industri rumah tangga tempat mereka beroperasi untuk mencapai efisiensi pertumbuhan ekonomi, menciptakan lapangan kerja dan menghasilkan pendapatan. Jumlah Produksi ditahun 2020 sebanyak 15.480 Kg, ditahun 2021 sebanyak 16.200 Kg, selanjutnya ditahun 2022 sebanyak 18.000 Kg (Industri Dwi Berkah). Jumlah produksi tahu IKM Dwi Berkah yang semakin meningkat setiap tahunnya dikarenakan tingginya permintaan dari pembeli. Tujuan dari penelitian ini adalah untuk mengetahui keragaan usaha tahu di industri rumah tangga Dwi Berkah Kabupaten Buton. Populasi dan sampel dalam penelitian sebanyak 1 Industri. Teknik pengumpulan data yang dilakukan melalui observasi dan wawancara. Variabel dalam penelitian ini adalah  Keragaan usaha dan Efisiensi usaha. Hasil penelitian disimpulkan bahwa keragaan usaha sangat menguntungkan dimana memperoleh keuntungan sebesar Rp.10.972.255 per bulan dan memiliki efisiensi usaha sebesar R/C 1,4. Hal ini dihitung berdasarkan skala yang telah diadaptasi dari BEP (Break Event Point) apabila R/C >1 maka usaha dianggap sudah dijalankan dengan efisien atau dengan kata lain menguntungkan
Evaluation of Blood Pressure in Children Treated with Ceftriaxone: A Case-Control Study
Authors: Esmaeili Mahdi , Sarmadian Roham , Fatahibayat Gholamali , Yousefichaijan Parsa , Habibi Danial
Published: September 2023

Background: In children, high blood pressure can develop into hypertension and its consequences during puberty and adulthood. High blood pressure in children is often secondary to other causes, including renal diseases. Nephrolithiasis is one of the causes of secondary hypertension. The extensive use of cephalosporins in hospitals, particularly ceftriaxone, can result in nephrolithiasis. Therefore, the purpose of this study was to assess the relationship between ceftriaxone treatment and elevated blood pressure in children.
Method: The research was conducted as a case-control study over an 18-month period from 2018 to 2019. In this study, blood pressure was measured in 111 children aged 3-13 years who were hospitalized at Amir Kabir Hospital in Arak and received ceftriaxone for at least 48 hours. As a control group, 111 children who did not receive ceftriaxone had their blood pressure measured. The blood pressure levels and percentiles of children in the two groups were then compared.
Result: In the case and control groups, the mean age was 5.1±1.61 and 6.04±2.4 years, and the mean height was 109.17±10.71 and 114.86±12.95 cm, respectively. A slightly higher mean systolic blood pressure percentile was observed in the case group (65.59±18.17) than in the control group (65.28±14.51) (P=0.112), and the mean diastolic blood pressure percentile was also slightly higher in the case group (58.89±18.88) than in the control group (54.85±19.28) (P=0.317). The difference in diastolic blood pressure was greater than in systolic blood pressure. However, these detected differences were slight and not statistically significant.
Conclusion: This study showed no association between blood pressure levels and ceftriaxone treatment in children older than three years who received the medicine for at least 48 hours. However, additional research is suggested, focusing on the effects of the medicine at higher doses and over a longer period of time following administration.
Safety of Adalimumab: An Analysis of the FDA Adverse Event Reporting System (FAERS) Database
Authors: Ghanem Buthainah
Published: September 2023

Objective: This study aims to assess the safety profile of adalimumab and its biosimilars for each approved indication by analyzing adverse events (AEs) reported in the FDA Adverse Event Reporting System (FAERS) database.
Method: We conducted a retrospective pharmacovigilance analysis of AE reports documented from 2002 to 2022 in the FAERS database. This analysis included descriptive statistics and binary logistic regression analyses. We calculated reporting odds ratios (RORs) with 95% confidence intervals (CI) to investigate safety signals related to the disproportionate reporting of serious AEs for adalimumab and its biosimilars compared to currently available biological products for the same proposed indications.
Results: A total of 543,873 AEs related to adalimumab treatment were reported, with 49.8% classified as serious. Hospitalization was the most frequently reported AE. Risk factors associated with serious AEs included age (≥60 years), male sex, and the concurrent use of adalimumab (ROR >1, P<0.05). Adalimumab exhibited a lower risk of serious AEs compared to abatacept, certolizumab, infliximab, or rituximab. Conversely, etanercept and ixekizumab showed lower odds of serious AEs than adalimumab (ROR <1, P<0.05).
Conclusion: In summary, these findings suggest that adalimumab has a well-tolerated safety profile for approved indications when compared to currently available biological alternatives.
Therapeutic Potential of Traditional Medicinal Plants from Algeria for Treatment of Liver Diseases
Authors: Ali Boutlelis Djahra , Sabrina Chrait , Mounia Benkaddour , Salah Benkherara , Ibtissam Laib , Chaima Benine
Published: September 2023

The objective of our study is to conduct an ethnobotanical investigation of traditional medicinal plants used by people in El-Oued state, southeast Algeria, for the treatment of liver diseases. We collected data through personal interviews and questionnaires. In total, we conducted interviews with 156 respondents, the majority of whom were aged 50 or older. Our study of medicinal plants used for treating liver diseases led to the discovery of 78 species from 41 families and various genera, including 52% of medicinal plants found in the wild. Approximately 77% of these plants were primarily used in dried form for remedy preparation. The most commonly employed preparation method was decoction. Interestingly, 70% of the participants mentioned Zizyphus lotus (L.) Lam., Silybum marianum L., and Atriplex halimus L. as sources for treating liver illnesses. This investigation revealed that many people in the research region still rely on herbal remedies to treat liver disorders. Moreover, the present study provides valuable ethnobotanical data on medicinal plants, serving as a foundational resource for future extensive research in this field.
C-Jun N-Terminal Kinases Inhibition: A New Approach to the Regulation of Venlafaxine Pharmacokinetics
Authors: Zyuz`kov Gleb , Zyuz`Kova Yuliya , Bryushinina Olga , Abdrashitova Nataliya , Lakeev Alexandr , Tsuran Darya , Frelikh Galina , Udut Vladimir
Published: September 2023

The effect of the c-Jun N-terminal kinases (JNK) inhibitor 'IQ-1' on the pharmacokinetics of the antidepressant venlafaxine was studied. An acceleration of the metabolism of this psychotropic agent was revealed when a modifier of intracellular signal transduction was administered to experimental animals in vivo. The JNK blockade was accompanied by a decrease in the plasma level of the antidepressant without changes in the concentration of the pharmacologically active metabolite O-desmethylvenlafaxine. The results obtained indicate a modification of the pattern of venlafaxine biotransformation, involving a change in metabolic pathways with an increase in the formation of other metabolites, or a correction of its distribution in the body. The revealed properties of the JNK inhibitor can be used to develop fundamentally new approaches to improve the effectiveness of antidepressant therapy with venlafaxine within the framework of implementing the 'Strategy for Targeted Regulation of Xenobiotic Metabolism and Drug Pharmacokinetics'.
Decriminalization of Narcotics in Jordanian Legislation: Theory and Practice
Authors: Alhrerat Khalid Abdulrahman , Zakaraya Zainab , Abu Dayyih Wael , Hailat Mohammad , Hamad Mohammed , Alabbadi Ibrahim
Published: September 2023

This study delves into recent legislation in Jordan regarding the decriminalization of narcotics and traces the evolution of related legislation in the country. It explores the definition and underlying philosophy of decriminalization while examining arguments from both proponents and opponents of drug decriminalization from a jurisprudential perspective. Additionally, the research sheds light on practices that have emerged in response to the decriminalization of narcotics in other jurisdictions. The study thoroughly examines the advantages and disadvantages of decriminalizing narcotics, analyzing its potential impact on drug consumption. Finally, the researcher proposes the implementation of a gradual and partial systematic plan within Jordanian legislation to address the growing trend of drug decriminalization. The paper also provides insights into the stances of the United States and other countries on this issue and how their legislations have addressed it.
The Influence of ChatGPT and AI Tools on Vietnamese Education
Authors: Nguyễn Thu
Published: September 2023

Artificial Intelligence (AI) has become increasingly integrated into various sectors of society, including education. This paper explores the impact of ChatGPT and other AI tools on Vietnamese education. We examine the benefits, challenges, and implications of AI in the Vietnamese educational context, focusing on its role in enhancing teaching and learning, addressing educational disparities, and fostering innovation. We also consider the ethical and cultural aspects of AI adoption in education. Through a comprehensive analysis of existing research and case studies, we provide insights into the potential future developments and recommendations for harnessing the full potential of AI in Vietnamese education
Development of Learning Facilities for ADHD Student Aged 6-9 Years Old at Special School in Indonesia
Authors:   Department of Industrial Design, Institut Teknologi Sepuluh Nopember, Surabaya, Indonesia., Tristiyono Bambang , Tualeka AC Halimatus Sa’diyah ,   Department of Industrial Design, Institut Teknologi Sepuluh Nopember, Surabaya, Indonesia.
Published: September 2023

Attention-Deficit / Hyperactivity Disorder (ADHD) is a neurobiological disorder in the form of inability to focus attention, easily distracted, impulsive, and hyperactive. Children with ADHD are usually aggressive, unable calm down, are difficult to teach, and have trouble focusing when doing an activity. With this, children with ADHD need treatment, special handling, as well as facilities and infrastructure that are suitable for children with ADHD. One special facility for ADHD that looks significant compared to other normal facilities is a study furniture designed for children with ADHD. The study furniture is important because it often interacts with children with ADHD for a long time. The good consideration of a design is the fulfillment of needs that can adapt to user conditions. To get a solution, interviews with experts were conducted, potential users that is children with ADHD aged 6-9 years, literature studies on ADHD, active seating, fidgeting, ergonomics, color, benchmarking to product existing, and analysis of user needs. The results of this design are furniture sets in the form of tables and chairs that use active seating, calm, adjustable, and safe as the concept to support the learning activities of children with ADHD in special schools. The chair design uses the concept of active seating in the form of whole body fidgeting to support hyperactive and inattention symtoms. This design utilizes digital simulation to digitize the concept and simulate it, reducing trial and error during prototype development. Furniture with adjustable height system for children aged 6-9 years with a simple and safe form for the needs of children with ADHD. This design uses muted brown color to give a clean impression and not cause distraction, combined with a muted blue color to give a calming feel from a psychological standpoint and fulfill user preferences.
The effect of Urf (common law) on family laws in Islamic Jurisprudence
Authors: Rostami Soheila , Hafidi Wrya , Roustaie Mehrangiz
Published: September 2023

Common law as something accepted by the rule of wisdom found in the very self of humans formed the earliest type of the legal systems of societies. In most of the legal systems of the world, common law is known as one of the most important resources and is of high significance. Most of the Islamic jurisprudents agree on the authority of common law as an independent or dependent reason or proof. In this regard, the jurisprudents have referred to reasons of the Book (Holy Quran), the Tradition (Sunna), and wisdom. Family laws are included as the most potential fields for the common law to play a significant role in updating the rules and placing them in the right path of recognizing the required components. Thus, by applying a descriptive-analytical method, the present study attempts at studying the function of common law in laws related to the family through investigating the nature, range of inclusion, and legitimacy of common law among the jurisprudents of different Islamic schools and sects as well as studying the opponents’ reasons for its documentary authority
Assessment of Livelihood Activities of Beneficiaries of Village Alive Development Initiative, Kwara State, Nigeria
Authors: P. Popoola O. , J. Yusuf A. O. T. , D. Ishola S. O. , T. Adara C. , S. Yakubu , O. Oyeyemi P. , I. Nwankpa F.
Published: September 2023

The study assessed the livelihood activities of beneficiaries of Village Alive Development Initiative (VADI) in Kwara State, Nigeria. It specifically identified the types of livelihood of beneficiaries in the study area and assessed how the programme benefited rural communities. Data were collected using structured questionnaire administered to fifty-seven beneficiaries using three-stage sampling technique. Data generated were analyzed with descriptive and inferential statistical tools. The study revealed that the age bracket is uniformly distributed across the age groups with greater proportion (37.78%) of the respondents’ ages falling within the age bracket of above 56years.Majority of the respondents were married (91.11%) and educational exposure (84.4%). Also, about 25% (11) of the respondents earned less than ₦100,000 annually and (77.27%) made use of their personal savings to run their enterprises. The majority of farmers engaged in crop production (77.27%) and plant grains (57.14%) as their major crop produce. Also, majority (72.09%) of the Community farmers had no access to credit facilities and nearly half of the respondents (46.51%) did not practice record keeping. The study further showed that majority (56.1%) adopted the banking savings as their preferred mode of saving and (83.33%) do not belong to any existing groups and cooperatives. (64%) had never participated in any agricultural and rural development project. The study found out that access to credit facilities was the major interest of communities and existing groups were not strong enough to control market or operate as pressure group to influence access to credit facilities. Thus, the study recommends a simple and functional micro credit delivery system to the farmers in order to enable them access loan for their businesses, there should be awareness of the project in order to increase and strengthen their livelihood activities.
Rosa Damescana: A review of its conventional uses Phytochemistry and Pharmacology
Authors: Chishti Muhammad Amjad , Akram Muhammad , Laila Umme , Zainab Rida , Ifthikar Momina , Ozdemir Fethi Ahmet , Kebede Isayas Asefa
Published: September 2023

In the past ten years, the use of herbal and ayurvedic medications has gained international attention due to their potential medicinal and financial benefits. The consistency, safety, and effectiveness of herbs have come under scrutiny due to their extensive use throughout the world. Also known as Black Cutch, Acacia catechu wild is employed for several pharmacological and phytochemical functions. In Indian traditional medical systems, it is a very powerful medicinal plant. As a result, providing adequate logical support or evaluation for herbal health arguments has become the standard. This article examines traditional knowledge or claims, phytochemical and pharmacological justifications, as well as pharmacogenetic reasoning, and the plant's prospective applications. Since ancient times, people have been taking advantage of the earth's resources to discover novel phytoconstituents that can be used to cure a wide range of illnesses. Many of these treatments are still useful in today's medicine. The search for potent natural and fresh semi-synthetic or copied compounds to treat human ailments is still ongoing, according to emerging data, and it is leading to the discovery of novel potent natural and fresh semi-synthetic or copied compounds.
Climate Change and Crop Adaptation: Its Impacts and Opportunities for Crops Production
Authors: Zigene Zewdinesh Damtew
Published: September 2023

Climate change is the departure of a region's weather patterns from the norm or from conditions that have been historically documented as usual. The term "climate" refers to long-term weather patterns, whereas the term "climate change" refers to changes in weather patterns through time. Climate, which can refer to a county, state, continent, or the entire world, is simply the pattern of weather that prevails on average in a location. Despite rigorous analysis of weather data conducted, it is difficult to forecast the effects of climate change for a specific agricultural operation because of the numerous human and environmental elements influencing it as well as the increased variability in weather over time and across space. After more than a decade of disagreement, the scientific community has now come to the conclusion that climate change is one of the planet's most pressing environmental issues of this century. The issue has evolved from a scientific to a political and economic matter, with dire economic repercussions, according to conventional thinking. Climate change has numerous impacts on the production of crops. The productivity of crops is subjected to a variety of stress and potential yields are rarely achieved. In order to sustain crop production with present-day challenges, there have to be packages to manage stresses caused by climate change. If properly managed, some sectors such as the horticulture sector could be might benefit from the impact of climate change in terms of energy, productivity, and market advantages. This review paper, therefore, reviews the impact opportunity and challenges of climate change on the productivity of crops.
Reproductive Performance of Pig Based on Age of the Sows and Litter Size
Authors: Gustina Sri , Pasau Nopriadi Sambo , Sukoco Hendro , Hasbi Hasbi
Published: September 2023

Pigs farming is one of the livestock commodities that have the potential to be developed, so it is necessary to observe age of the sows and litter size to determine the reproductive performance of pigs. This study was conducted in the Jambutua village of Polewali Mandar Regency with descriptive methods by observing directly. A total of 60 sows were surveyed using saturated sampling. The parameters observed were the age of the sows and the litter size. The results showed that the age study of sows in Jambutua Village had an average age of 3 years with 4 times of births. Litter size increases with each birth. The average of litter size was the highest at the fourth parity of 12 piglets, followed by the third parity of 10, the second birth of 8, and the lowest number of piglets per birth, the first birth of 7. The results of the analysis conducted that the parity has a correlation with the age of sows with the significance value (P) is 0.000, and the correlation value (R2) is 39.2%.
An Examination of the Impact of Capital Flight on Economic Growth in Nigeria
Authors: Muhammad Sanusi Yakubu , Bello Umar Farida , Nwanneka Nduka Kodili , Adamu Momohsanni
Published: September 2023

The study examined the impact of capital flight on economic growth in Nigeria applying annual data sourced from Central Bank of Nigeria Statistical Bulletin from 1986 to 2020 and using an Error Correction Model (ECM). The results of the cointegration test demonstrated that the variables have a long-term relationship. The findings show that most of the constituents of Capital flight (first, second and third lags of foreign direct investment and portfolio Investment) have negatively impacted Nigeria’s economic growth. In contrast, external debt and current account balances positively impact on economic growth in Nigeria. This, therefore, confirmed that changes in capital flight impact economic growth in Nigeria. The study recommends that the government and stakeholders create an attractive, conducive, and enabling environment suitable for ease of doing business that will attract and retain foreign investors in the country. More importantly, the Government should ensure proper use of the funds borrowed, by channelling it to the productive sector of the economy and will also increase Government revenues.
Language Changes and the Evolution of Christian Doctrines in Cameroon
Authors: Ndi Eunice Ndem
Published: September 2023

This article examines how the world through Cameroon is experiencing rapid changes in the sphere of Christianity and how language is responding to such changes. Language is a tool of communication that enables societal realities to be effected. New doctrines, practices and ideologies conceived by denomination and church planters are advocated via meaningful words and expressions, including absolute adjectives in church names, songs, crusade and sermon themes, to communicate the intended information to participants. Preachers use words and expressions that are captivating enough to appeal to the senses of their followers and potential followers. They use words and expressions that purport to unveil the quality, objectives and mission statements of their churches in an attempt to attract members. Most of the names insinuate miraculous and deliverance practices that seem to meet the needs of potential followers, but the issue is that if the language of persuasion does not meet the needs of the converts at the end of the day, language use will be volatile as converts will subsequently backslide.
Management of Anesthesia in Pre-Eclamptic Patients with Covid 19 Infection
Authors: Morshed Mohammed Mamun , Faruk Abdullah Al
Published: September 2023

Background: Pregnant women with immunological and cardiopulmonary system abnormalities may experience more severe symptoms from respiratory virus infections. Objectives: The aim of this study was to assess the management of anesthesia in pre eclamptic patients with covid 19 infection. Methods: This cross-sectional descriptive study was carried out in the Department of Anaesthesia, Uttara Adhunik Medical College Hospital, during October 2020 to September 2021. A total of 50 pregnant women with pre-eclampsia and had positive polymerase chain reaction (PCR) test for COVID-19 with nasopharyngeal swabs were included in the study irrespective of age and patients who were not willing to participate were and who were clinically suspected (such as a clinical situation or travel history) but tested negative for COVID-19 excluded from this study. Statistical analyses of the results were be obtained by using window based Microsoft Excel and Statistical Packages for Social Sciences (SPSS-22), where required. Results: The mean age of the patients was 26± 2.0 years. 36% patients were within 26-31 weeks of gestational age, 40% patients were within 32-36 weeks of gestational age, 20% patients were within 37-42 weeks of gestational age, and only 4% had more than 42 weeks of gestational age. About 60% patients had mild pre-eclampsia and 40% had severe pre-eclampsia. 98% patients had given spinal anesthesia and 2% had given epidural type of anesthesia. The indication for caesarian section was 50% for severe pre-eclampsia, 25% for uterine rupture in pre-eclampsia and 25% for previous caesarean section. The mean Hemoglobin was 12.17 ± 1.70, mean Aspartate aminotransferase was 28.05 ± 21.11, mean Alanine aminotransferase, was 17.06 ± 12.98, mean Creatine was 0.68 ± 0.71, mean C-reactive protein was 2.10 ± 2.33 and mean D-Dimer was 3.00 ± 2.26. About 60% of the patients were fit to discharge within 4 days and 40% within 5 days. Conclusion: Preeclampsia as one of pregnancy related complications is a notable burden of adverse health. Regional anaesthesia is not considered to be prohibited by the diagnosis of COVID-19 alone. In conclusion, COVID-19-infected pregnant women should be managed by specialised teams in a multidisciplinary facility, and all medical personnel involved in the caesarean section should be careful to use Level-3 PPE equipment. Due to the increased risk of infection and morbidity in general anaesthesia in pregnant women with COVID-19, regional anaesthesia becomes more prevalent. We also noted that there is no umbilical chord transmission from mother to child.
Portal Hypertension in Children at the Department of Pediatric Gastroenterology & Nutrition, BSMMU, Dhaka, Bangladesh
Authors: P Marjan , ASMB Karim , M Rukunuzzaman , SR Das , M Mondal , N Sarker , H Akther , AS Chowdhury
Published: September 2023

Background: Portal hypertension is the hemodynamic abnormality frequently associated with serious liver disease, although it is recognized in a variety of extrahepatic diseases also. Portal hypertension is an important cause of morbidity and mortality in Bangladeshi children. Development of esophageal varices and bleeding is one of the major complications of CLD. The mortality from each episode of variceal bleeding is 30-50% depending on the clinical status of the patient. All conditions that interfere with blood flow at any level within the portal system can lead to portal hypertension. For better management of this disorder, it is important to determine the underlying cause. Objective: To assess the portal hypertension in children at the Department of Pediatric Gastroenterology & Nutrition, BSMMU, Dhaka, Bangladesh. Methods: This cross-sectional descriptive study was conducted at the Department of Pediatric Gastroenterology & Nutrition, BSMMU during the period Jan 2018 to July 2019. 50 patients who were diagnosed as portal hypertension were determined by Upper GI Endoscopy. Doppler USG was also done for supporting the diagnosis of Portal HTN as well as to differentiate between extrahepatic Portal HTN and CLD with portal HTN. Demographic data and other related information regarding etiology and complications were recorded in a standard datasheet. Results: Results: A total of 50 cases were included in this study. Their age range was 1.5-16 years. It was observed that 21 (42.0%) patients belonged to age group 6-10 years. The mean age was 9.22±9.85 years with ranged from 2.5 to 16 years. It was observed that almost two third 31 (62.0%) patients were male and 19 (38.0%) were female. Among 50 patients 29 were diagnosed as extrahepatic portal hypertension and 21 were diagnosed as CLD with portal HTN. Shows the etiology of portal hypertension of studied patients. Extrahepatic portal hypertension was the most common etiology (58.0%). Among CLD patients Wilson disease was the most common (13; 26.0%). Two (4.0%) patients were cryptogenic CLD and two (4.0%) were Budd Chiari Syndrome. One patient was Biliary cirrhosis and one patient had Auto immune hepatitis. Conclusion: We concluded that Extrahepatic Portal HTN is the most common cause of portal hypertension in children in this center. Among the intrahepatic causes of portal HTN Wilson disease was the
Functional Composition, Minerals and Antioxidant Vitamins Content of Juice of (Botria africanus)
Authors: Zubairu A. Y. , Saidu I. , Mukhtar M. , Sani J. , Zubairu A. , Nababa H. A. , Abubakar S. S. , Habibu A. , Ibrahim Z.
Published: September 2023

Fruits play important role in human nutrition, particularly as sources of dietary fiber, minerals, and vitamins. This research is able to highlight essential composition available in juice of (Botria africanus), the functional composition, mineral and antioxidant vitamin contents were determined. The results identified availability of nutrients were obtained to be moisture content (20.17±0.76mg/dL), ash content (5.33±0.58mg/dL), crude protein (3.81±0.02mg/dL), crude lipid (12.33±0.12mg/dL), crude fibre (1.33±0.58mg/dL), and carbonhydrate (57.08±0.01mg/dL). The mineral contents were also identified to be Iron (3.723±0.003mg/dL), Manganese (0.405±0.005 mg/dL), Magnesium (ND±ND mg/dL), Phosphorus (31.15±0.050mg/dL), Potassium (5800 ± 100.000mg/dL), Sodium (150 ± 5.000mg/dL) and Zinc (0.016±0.008mg/dL) at the end the vitamins content were also obtained to be vit C> vit E > vit A the values are 53.6 ± 0.300> 50.21 ±3.357> 1.158±0.008, the research concluded that juice of (Botria africanus) contained an important nutritional components that are useful which are able to protect the body against oxidative stress.