bluuebunny/crossref_metadata_2025 huggingface dataset:
Quantifying Benefit-Risk Trade-Offs Toward Prophylactic Treatment Among Adult Patients With Hemophilia A in China: Discrete Choice Experiment Study (Preprint)
Authors: Wang Limin , Liu Shimeng , Jiang Shan , Li Chaofan , Lu Liyong , Fang Yunhai , Li Shunping
Published: January 2023

BACKGROUND

Hemophilia A is a chronic condition that requires meticulous treatment and management. Patient preferences for prophylactic treatment can substantially influence adherence, outcomes, and quality of life, yet these preferences remain underexplored, particularly in China.

OBJECTIVE

This study aimed to investigate the preferences for prophylactic treatment among Chinese adult patients with hemophilia A without inhibitors, considering clinical effectiveness, side effects, dosing mode, and dosing frequency.

METHODS

A discrete choice experiment was used to elicit patient preferences for prophylactic treatment of hemophilia. The study was conducted across 7 provinces in China with socioeconomic and geographical diversity. Subgroup analysis was performed according to education level, geographic location, and treatment type, alongside the exploration of benefit-risk trade-offs.

RESULTS

A total of 113 patients completed the discrete choice experiment questionnaire, and we included 102 responses for analysis based on predetermined exclusion criteria. The study found that patients prioritized reducing annual bleeding times and avoiding the risk of developing inhibitors over treatment process attributes. Subgroup analysis revealed that lower-educated patients and those from rural areas attached more importance to the dosing mode, likely due to barriers to self-administration. Patients demonstrated a clear understanding of benefit-risk trade-offs, exhibiting a willingness to accept an increased risk of developing inhibitors for improved clinical outcomes.

CONCLUSIONS

This study provides valuable insights into the preferences of patients with hemophilia A for prophylactic treatment in China. Understanding these preferences can enhance shared decision-making between patients and clinicians, fostering personalized prophylactic treatment plans that may optimize adherence and improve clinical outcomes.
Precision Public Health Approach in Outbreak Management: Protocol for a Scoping Review (Preprint)
Authors: Mohd Hairi Farizah , Rajendran Ellappa Ghanthan , Supramaniam Rama Krishna , Tengku Mohd Tengku Amatullah Madeehah
Published: January 2023

BACKGROUND

Precision Public Health (PPH) is a newly emerging field in public health medicine. The application of various types of data such as clinical data, personal data, and environmental data combined into a large-volume database known as Big Data (BD) can improve public health initiatives including outbreak management. With good quality BD, the PPH is capable to deliver more tailored interventions to a specific population within a specific timeframe. However, the application of PPH possesses several challenges and limitations that need to be addressed.

OBJECTIVE

The objective of the present study is to provide evidence of the various use of PPH in outbreak management, the types of data that could be used in PPH application, and the limitations and barriers in the application of the PPH approach.

METHODS

We adopted the reviewer framework proposed by the Joanna Briggs Institute in the present study. Articles or studies will be searched in PubMed, Web of Science, and Science Direct. The inclusion criteria were English publications between January 2017 and January 2023, all experimental studies, observational studies, and text or opinion papers that show potential evidence of the PPH application in outbreak management. Our selection of articles was based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) for Scoping Review guidelines. Data extraction was performed using a standardized data extraction form. The outcome of the evidence assessment will be narrative instead of quantitative.

RESULTS

The database search resulted in 1059 articles. Upon completing the screening and eligibility stages, 30 articles were included in the scoping review. As of 21 February 2023, the scoping review is in the descriptive synthesis stage. We anticipate the scoping review report will be completed by June 2023.

CONCLUSIONS

This scoping review protocol presents the methods that guide the scoping review and identify and map studies that used a precision public health approach in addressing communicable disease or outbreak management. This review may address the advantages and disadvantages of implementing the precision public health concept as well as the limitations and barriers. This evidence could be beneficial for policymakers and implementers in improving outbreak management by incorporating precision public health approaches.

CLINICALTRIAL
Characteristics, completion and publication of PROSPERO records in regional anesthesia for acute perioperative pain
Authors: Carev Martina , Čivljak Marta , Puljak Livia , Došenović Svjetlana
Published: January 2023

Aim:
We analyzed characteristics and completion status of Systematic Reviews (SRs) about regional anesthesia for acute perioperative pain relief registered in PROSPERO.
Materials & methods:
PROSPERO was searched on 5 January 2022. Characteristics of PROSPERO records, completion status and publication information were extracted. PubMed and Google Scholar were searched by 31 May 2022, for additional published SRs. The inconsistency of PROSPERO records' status was analyzed by comparing the most recent PROSPERO status with subsequent publication of completed SR. Time-to-publication was calculated.
Results:
Almost half of 174 included PROSPERO records (49%) were registered in 2021. A median of 3 (IQR: 2–4.75) authors, and a search of 4 information sources (IQR: 3–5) was planned. At first registration, 51 (29%) records had already started or completed formal screening. PROSPERO records included mostly adults (48%) undergoing trunk blocks (56%), with pain intensity (74%) as a main outcome. 147 (84%) PROSPERO records had a status “ongoing”. Yet, 71 (41%) PROSPERO records were completed SRs, published after a median of 291 days. Inconsistency in status was found in 34% of PROSPERO records.
Conclusion:
Despite an increase in PROSPERO registrations about regional anesthesia, most were not published, and a third had inaccurate status.
VIBERSHIELD: An Intrusion Detection System
Authors: Sardey Dr. M. P. , Shah Tirth , Joshi Prajwal , Shah Krishna
Published: January 2023

Abstract: Dramatic increase in unlawful intruder movements throughout the countries boundaries demands design and development of unified border surveillance and intruder detection system. The purpose of this research aims to analyse the factors which affects the detection of vibrations that originates from underground or the ground surface resulting from footsteps, vehicles and animals. It also aims to detect and differentiate the vibrations and alarming the base camp using geophones and LORA communication.
Waterlogging effects on leaf element concentrations and cane weight of sugarcane genotypes
Authors:   ICAR-Indian Institute of Sugarcane Research, Lucknow-226 002, India, Singh S.P. , Singh S. ,   ICAR-Indian Institute of Sugarcane Research, Lucknow-226 002, India, Jain R. ,   ICAR-Indian Institute of Sugarcane Research, Lucknow-226 002, India, Pathak A.D. ,   ICAR-Indian Institute of Sugarcane Research, Lucknow-226 002, India, Pandey N. ,   Department of Botany, University of Lucknow, Lucknow-226 007, India
Published: January 2023

Aim: The aim of the present experiment was to examine whether waterlogging induced deficiency or excess of elements, is the cause for reduction in cane weight of sugarcane genotypes under waterlogged conditions. Methodology: The experiment was conducted in pots with eleven sugarcane genotypes grown under control and waterlogged conditions. Waterlogging treatment was imposed at 120 days crop age for a period of 60 days. Cane weight and element concentrations were measured at the end of waterlogging. Results: Compared to control, reduction in cane weight of sugarcane genotypes under waterlogging varied from 5.3% (A-46-11) to 32.3% (CoJ 64). Waterlogging caused a significant decrease in leaf N, P, K, S, Zn and Cu concentrations of sugarcane genotypes; the extent of decreases in leaf N and S were more and values for these elements dropped below their reported critical deficiency level for most genotypes. There was a significant inverse correlation between leaf K and S concentration, and reduction in cane weight of sugarcane genotypes, indicating that genotypes with high leaf K and S under waterlogging have relatively less reduction in cane weight. There were significant increase in the leaf Fe, Al, Mn and Na concentrations under waterlogging, however, increase in these elements were not correlated with reduction in cane weight of sugarcane genotypes. Interpretation: The results suggest that deficiencies of N, K and S rather than excess of Fe, Al and Mn is a major cause for reduction in cane weight of sugarcane genotypes under waterlogged condition. The genotypes tolerant to N, K and S deficiencies under waterlogging can be utilized in breeding program for developing sugarcane varieties with improved waterlogging tolerance. Key words: Cane weight, Element deficiencies, Element toxicities, Sugarcane, Waterlogging
Characterization of horse gram mutants for yield, nutrient, and anti-nutrient factors
Authors:   Sugarcane Research Station, Vellore-635 806, India, Sudhagar R. , Pushpayazhini V. ,   Department of Genetics and Plant Breeding, Agricultural College and Research Institute, Madurai-625 104, India, Vanniarajan C. ,   Department of Plant Breeding and Genetics, Agricultural College and Research Institute, Madurai-625 104, India, Hepziba S.J. ,   Department of Genetics and Plant Breeding, Agricultural College and Research Institute, Madurai-625 104, India, Renuka R. ,   Department of Biotechnology, Agricultural College and Research Institute, Madurai-625 104, India, Souframanien J. ,   Nuclear Agriculture and Biotechnology Division (NA&BTD), BARC, Mumbai-400 085, India
Published: January 2023

Aim: This experiment assessed the potential of induced mutagenesis in evolving variability for yield, nutritional and anti-nutritional, factors in horse gram. Methodology: The mutants were grown in three environments consisting of three sowing times and soil types and the data were pooled. D2 analysis was used to group the mutants. Based on the magnitude of variation and character inter-relationship, single plant yield was fixed as a selection criterion to identify promising mutants from clusters. The tagged high yielding mutants were profiled for macronutrients, micronutrients and anti-nutritional factors. Results: The induced mutagenesis evolved significant variability for yield attributing traits. It evolved the maximum variation for the traits number of pods per plant, number of clusters, plant height and single plant yield (CV= 34.80%; 33.90%; 33.80%, 30.44% and 29.60% respectively). A significant coefficient of variation was observed for nutrients (crude protein: 5.13%; crude fibre: 11.67%, crude fat: 13.44%; boron: 11.50%; magnesium: 11.52; phosphorus: 10.86; potassium: 9.53%; calcium: 18.33%; manganese: 14.25%; iron: 16.36%; copper: 12.20%; zinc: 14.50% and molybdenum: 18.41%) anti-nutritional factors (total phenol:17.24%; tannins: 10.88%; phytic acid: 16.14% and oxalic acid: 15.16%). Potential genetic stocks for yield combined with nutritional supremacy were identified for further utilization. Interpretation: Induced mutagenesis evolved potential mutants for yield and nutrients. Alas, a negative relationship between yield and nutrient contents was established. To improve yield in horse gram and alleviate malnutrition, the genotypes with an average single yield potential of 55-65 g shall be prioritized. Key words: Anti-nutritional factors, Horse gram mutants, Nutrients
A study on critical associations of media components on enhanced cellulase production from wild Trichoderma viride and cellulase immobilization on iron-oxide magnetic nanoparticles
Authors:   Centre for Biotechnology, Anna University, Chennai-600 025, India, Revathi D. , Ramalingam S. ,   Centre for Biotechnology, Anna University, Chennai-600 025, India
Published: January 2023

Aim: The current study is a preliminary step towards enhancing the cellulase productivity in wild Trichoderma viride which will enable robust valorization of non-edible lignocellulosic biomass through co-generative enzymatic saccharification, specifically concentrating on influence of individual media components on biomass growth and cellulase productivity. Further, cellulase immobilization on iron-oxide magnetic nanoparticles was also achieved that can increase the shelf life of the enzyme. Methodology: The cellulase production in the wild Trichoderma viride was enhanced using media design and formulation. EDC {1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide} functionalized iron-oxide nanoparticles were chosen to act as carriers for cellulase immobilization. The binding efficiency and relative activity were measured in addition to optimal pH and temperature for cellulase bound iron-oxide nanoparticles. Further, the hydrolysis efficiency of immobilized cellulases was also measured after which it was subjected to consecutive hydrolytic cycles to calculate the recycle rate. Results: A maximum growth rate of 60 PCV (Packed cell volume) and total cellulase activity of 7.4 U ml-1 was obtained on media design and formulation. 82.5% binding efficiency was achieved on EDC functionalized iron-oxide magnetic nanoparticles which showed good stability at 5pH and 500C. There was 44.4% activity loss after 5 consecutive hydrolytic cycles which showed steady decline with increased cycle number and finally at the end of the 10th hydrolytic cycle, 22.2% of total relative activity was retained. Interpretation: Unprecedented total cellulase activity from a wild strain was obtained through media design. The stability of cellulases was further enhanced using iron-oxide magnetic nanoparticle immobilization. Key words: Cellulases, Immobilization, Iron-oxide magnetic nanoparticles, Submerged fermentation, Trichoderma viride
Evaluación de una estrategia educativa sobre tuberculosis y diabetes mellitus para personal de salud de atención primaria en México
Authors: Chavarría-Guzmán Kathleen Lanette , Saldaña-Medina Caleb David , Leyva-López Ahidée Guadalupe , Ostos-Ortíz Olga Lucía
Published: January 2023

Antecedentes. En la literatura se ha identificado una asociación fuerte entre la tuberculosis y la diabetes mellitus, asimismo, algunos estudios han reportado un nivel bajo de conocimiento de esta relación por parte del personal de salud. Objetivos. Explorar el cambio en los conocimientos y actitudes del personal de salud de atención primaria sobre epidemiología y políticas públicas de la asociación de Tuberculosis (TB) y Diabetes (DM) después de una sesión de entrenamiento. Material y Métodos. Diseño de medición pre-post intervención de un solo grupo de 31 participantes, mediante un cuestionario estructurado autodiligenciado construido ad hoc. Se utilizaron las pruebas de rangos signados de Wilcoxon para estimar diferencias entre las evaluaciones pre y post, análisis de correlaciones y la prueba Chi cuadrada. Se consideró un conocimiento adecuado a puntajes mayores a 70%. Resultados.El 12,9% de los participantes tuvieron conocimientos adecuados en la evaluación previa, mientras que el 16,1% en la evaluación post. Hubo un aumento porcentual en el nivel de conocimientos (pre= 53,43% versus post= 58,27%) y actitudes (pre=89,56% versus post=96,29%); sin embargo, fue estadísticamente significativo sólo para las actitudes (p= 0.000). Conclusión. La evaluación inicial (pre) muestra la importancia y necesidad de entrenar al personal de salud para lograr el abordaje integral de un paciente con la  asociación TB-DM.
Enfermedad mínima residual por citometría de flujo en pacientes con leucemia linfoblástica aguda
Authors: Cuta Hernandez Estefania , Bernal-Estévez David Andrés , Cruz Baquero Claudia Andrea
Published: January 2023

Antecedentes. La citometría de flujo (CMF) es una técnica que permite el análisis multiparamétrico de poblaciones celulares, siendo esencial en la investigación biomédica y como herramienta diagnóstica. Esta técnica rápida tiene una alta sensibilidad, evaluandocaracterísticas en la población de interés como es el caso del tamaño, granularidad, complejidad del citoplasma celular y proteínas de que permiten la clasificación fenotípica y funcional de un gran número de células. Por estas razones, esta técnica ha adquiridoimportancia en el diagnóstico y seguimiento de enfermedades y anomalías hematológicas, como leucemias, síndromes mielodisplásicos y síndromes mieloproliferativos, entre otras. Objetivo. La presente revisión se enfoca en los avances en la implementación de la CMF en la Enfermedad Mínima Residual (EMR) presente en la Leucemia Linfoblástica Aguda (LLA), la cual es una población mínima leucémica que se detecta en un paciente después de suministrar un tratamiento oncológico, donde se evalúa su eficacia, el riesgo de una recaída y el proceso de remisión completa. Metodología. Se realiza una revisión no sistemática deliteratura en bases de datos, de los últimos 15 años, donde evalúen las implicaciones del uso de citometría de flujo en la EMR, de esta revisión se extraen aspectos relevantes al momento de emplear la CMF para el diagnóstico y seguimiento de pacientes con leucemias. Resultados. La CMF es una técnica muy versátil e importante para el diagnóstico y seguimiento de la EMR por su alta sensibilidad para la detección de bajos números de células resistentes a la terapia. Adicionalmente se muestra la importancia de la estandarización de protocolos como EUROFLOW para un adecuado procesamiento y análisis clínico de las muestras de pacientes.
The bargain purchase option: Should it be more than an option?
Authors: Kameel Tariq , Al-Hajaya Nour , Alqudah Mutasim Ahmad
Published: January 2023

This study examines the bargain purchase option, which gives the lessee the option to buy the leased asset at the end of the lease period at a price significantly less than its fair market value. The study analyses the approach that the laws of Jordan and the United Arab Emirates (UAE) employ to enable the lessee to practice this option (Al-Azzawi, 2013). To achieve this goal, the main foundations and characteristics of the lessee’s option to purchase are studied under both jurisdictions showing that while Jordanian law treats the option to purchase as a contractual choice (Al Khasawana, 2005), the UAE law moved further to protect the option by law. This difference is discussed in terms of its impact on the degree of protection that prospective users of financial leases may enjoy with regard to the bargain purchase option. This article concludes with some results and recommendations for sake of improvement, mainly the need to embrace legal protection of the option to purchase under the Jordanian legal system, and the need to grant the lessee the right to seek compensation in the case of lessor’s failure to transfer the leased property within the period set by the law in the UAE.
Successful Crizotinib-Targeted Therapy of Pediatric Unresectable ERC1::ALK Fusion Sarcoma
Authors: Wood Megan L. , Fanburg-Smith Julie C. , Brian James M. , White Jason , Powell Jonathan , Freiberg Andrew
Published: January 2023

Anaplastic lymphoma kinase ( ALK)-fusion sarcomas are
rare, part of the emerging theoretically-targetable tyrosine-kinase
RAS::MAPK-pathway fusion myopericytic-ovoid-sarcomas. We report
our clinicopathologic and treatment experience with an ALK-fusion
sarcoma. A novel ERC1-unaligned-ALK-fusion infiltrative
nonmetastatic low-grade sarcoma of the right hand of a 15-month-old male
was treated with crizotinib, an ALK tyrosine-kinase inhibitor as
oral monotherapy, inducing complete radiographic and clinical resolution
by 10 months and sustained response now 8 months after elective
discontinuation. Crizotinib can successfully be used to treat
unresectable novel ALK-fusion sarcomas.
Disturbance alters transience but nutrients determine equilibria during grassland succession with multiple global change drivers
Authors: DeSiervo Melissa , Sullivan Lauren L. , Kahan Larissa , Seabloom Eric , Shoemaker Lauren
Published: January 2023

Disturbance and environmental change may cause communities to converge
on a steady state, diverge towards multiple alternative states, or
remain in long-term transience. Yet, empirical investigations of
successional trajectories are rare, especially in systems experiencing
multiple concurrent anthropogenic drivers of change. We examined
succession in old field grassland communities subjected to disturbance
and nitrogen fertilization using data from a long-term (22-year)
experiment. Regardless of initial disturbance, after a decade
communities converged on steady states largely determined by resource
availability, where species turnover declined as communities approached
dynamic equilibria. Species favored by the disturbance were those that
eventually came to dominate the highly fertilized plots. Furthermore,
disturbance made successional pathways more direct under low nutrients,
revealing an important interaction effect between nutrients and
disturbance as drivers of community change. Our results underscore the
dynamical nature of grassland and old field succession, demonstrating
how community properties such as beta-diversity change through transient
and equilibrium states.
Allergic disease as a causal protective factor for severe covid-19: a multivariable mendelian randomization study
Authors: Lu Qianjin , Yu Yangyiyi
Published: January 2023

Allergic diseases were recently reported related to both SARS-CoV-2
infection and severe COVID-19 through observational studies. However,
their causal relationship remains unclear. Herein, we performed
univariate and multivariate Mendelian randomization (MR) studies to
investigate the causal association between various allergic diseases and
COVID-19. Genome-wide association studies (GWAS) summaries were used in
this study, with 360838 participants in the allergic disease database,
455449 in asthma, 217914 in allergic rhinitis (AR), and 205764 in atopic
dermatitis (AD). In univariate MR analysis, the allergic disease was not
causally in connection with SARS‐CoV‐2 infection but have a causal
protective effect on severe COVID-19. In contrast, no significant causal
effect was found of SARS-CoV-2 infection/severe COVID-19 on the allergic
disease. AD, mixed asthma, and childhood asthma were causal protective
factors for severe COVID-19. Multivariate MR analysis further revealed
the dominant role of asthma in allergic diseases and the dominance of
childhood asthma in asthma subtypes. In summary, this study, based on
the population genetic variation model, pointed out the protective
effect of allergic diseases against severe COVID-19, which may provide
some inspiration for further exploration of the pathophysiological
mechanisms of COVID-19.
THE RELATIONSHIP BETWEEN ECONOMIC GROWTH AND MIGRATION IN TERMS OF 14 EUROPEAN UNION COUNTRIES AND TURKEY
Authors: Yavuz Hasan , Parlinska Agnieszka
Published: January 2023

Efforts to get rid of poverty cause migration movements that have consequences not only for themselves, but also for future generations. Migration movements affect many economic variables such as human capital, demand, supply, the balance of payments, income distribution, wage level, and national income. The literature on migration is often studied in the economic, political and security fields. This study focuses on the relationship of migration with economic growth. There are studies that determine two-way causality in the relationship between economic growth and migration. It is seen that the country groups specified here can explain these different results. In this study, our purpose is to investigate whether international migration affects the economic growth of the receiving country. Therefore, the actual relationship between migration and the eco- nomic growth rate in terms of economic size using 14 similar European Union countries and Turkey for the period 1978-2019 (with panel data analysis) was tested. It is seen that the test results explain the positive effects of migration in accordance with the literature.
Relacja ziemia-praca w warunkach finansowego wsparcia rolnictwa na przykładzie wybranych krajów świata i Unii Europejskiej-15 po 1986 r.
Authors: Czyżewski Andrzej , Kułyk Piotr
Published: January 2023

W artykule przedstawiono zmiany zachodzące w alokacji zasobów ziemi i pracy w rolnictwie w 30. krajach, w tym UE-15. Zwrócono uwagę na zróżnicowanie w zachodzących przekształceniach w poszczególnych państwach wskazując na procesy dominujące i występujące osobliwości. Wskazano na znaczenie finansowego wsparcia na alokację zasobów w rolnictwie. Przedstawiono zależność pomiędzy jego zmianami a zmianami zasobu pracy, podkreślając, iż impulsy fiskalne oddziaływały na dynamikę realokacji tych zasobów.
Obszary wiejskie i rolnictwo jako źródło dóbr publicznych w agroturystyce
Authors: Przezbórska-Skobiej Lucyna
Published: January 2023

Wielofunkcyjne obszary wiejskie, wielofunkcyjne rolnictwo i wielofunkcyjne gospodarstwo rolne dostarczają społeczeństwu wielu różnych dóbr o charakterze rynkowym i nierynkowym (dóbr publicznych). W ostatnich latach dyskusja nad problematyką dóbr publicznych oferowanych przez obszary wiejskie, rolnictwo i gospodarstwa rolne nasiliła się w związku z debatą na temat przyszłości Wspólnej Polityki Rolnej, a w szczególności nad wsparciem finansowym sektora rolnego i obszarów wiejskich. W dyskusjach tych pojawia się także agroturystyka jako forma aktywności, która nie może rozwijać się bez dóbr publicznych dostarczanych przez obszary wiejskie, rolnictwo i gospodarstwa rolne.
Konkurencyjność sektora rolno-spożywczego UE w świetle wyników handlu zagranicznego wybranych państw
Authors: Wieliczko Barbara
Published: January 2023

Wobec rosnącej konkurencji na światowych rynkach produktów rolno-spożywczych stałe podtrzymywanie potencjału konkurencyjnego sektora rolno-spożywczego UE nabiera rosnącego znaczenia. Celem artykułu jest ocena stanu konkurencyjności sektora rolno-spożywczego UE dokonana w oparciu o wyniki handlu zagranicznego artykułami rolno-spożywczymi oraz określenie kierunków działań mających na celu utrzymanie pozycji handlowej UE. Uzyskane wyniki wskazują na systematyczny wzrost wartości wymiany handlowej oraz jej koncentrację na wybranych grupach produktów. Wskazano również na możliwość konkurowania w oparciu o jakość oraz unikalną specyfikę produktów rolno-spożywczych wytwarzanych w UE.
Rozwój OZE na obszarach wiejskich i ich wpływ na środowisko przyrodnicze w opinii doradców rolnych
Authors: Wielewska Izabela
Published: January 2023

Działania dotyczące rozwoju energetyki rozproszonej i prosumenckiej stanowią znaczący element zrównoważonego rozwoju obszarów wiejskich. Mądre i efektywne wykorzystywanie energii winno się bowiem opierać na zasadach zrównoważonego rozwoju i sprzyjać rozkwitowi społeczno-gospodarczemu tych terenów, a także poprawie walorów środowiskowych i jakości życia mieszkańców. Inwestycje w energetykę odnawialną wiążą się z obniżeniem ujemnego wpływu na środowisko (degradacji gleb i krajobrazu, emisji zanieczyszczeń, powstawania odpadów). Analizę badawczą dokonano na podstawie wyników badań ankietowych, które zostały przeprowadzone w kwietniu 2014 roku wśród doradców rolnych i rolno środowiskowych z województw kujawsko-pomorskiego i pomorskiego. W opinii badanych, zarówno stan infrastruktury energetycznej, jak i poziom usług energetycznych na wsi jest niski. Chociaż wzrost udziału energii z OZE w Polsce jest niższy, niż w UE, to jednak niesie ze sobą ogromne możliwości dla ochrony środowiskowych walorów obszarów wiejskich.
Characteristics Determining a Market Value of an Agricultural Real Estate with use of Multiple Correspondence Analysis
Authors: Kozioł-Kaczorek Dorota
Published: January 2023

The paper consider a problem of identify a variables affecting market value of agricultural real estate. Furthermore, in the paper was discussed a problem of identify a homogenous group of agricultural real estate. The purpose of this paper is to determine the possibilities of using of the Multiple Correspondence Analysis in terms of agriculture real estate. This method has a special relevance in situations with a lack of information, large numbers of possible variables, unknown market and a limited number of transactions, as is often in the case with agricultural real estate.
Research on the Social and Economic Differentiations in the Greek Rural Sector During the Period 1830-2030
Authors: Papailias Michail
Published: January 2023

In 1830 farmers constituted the majority of the Greek population. Part of these was small landowners or small livestock farmers, while the largest part of them was landless. The large farms were few. In the 1920s the entrance of 1.5 million refugees from Asia Minor and the departure of 600 thousands Muslims (with the exchange of populations) had as a result the dissolution of the manors, which were in the hands of the Turks. In the year 1950 due to the German occupation (1941-1944) and civil war (1946-1949) the agriculture returned in the level of the 1930s. In 2000, almost twenty years from the Greece’s accession to the EU (in 1981), the massive subsidies and the clear agricultural policy, led to disruption of productivity of rural sector.
The estimates for 2030 are formulated both from the changes that have occurred over time and from the consequences of the accession of Greece in the support mechanism (2010), after the silent bankruptcy of the country. The purpose of this paper is to reflect the changes in the social structure of agriculture from independence (1830) until today and to make estimations for 2030. The Greek case differs from that of European countries, as it has not developed the institution of manor and similar as extensive feudal relations. It also differs from the countries of the Balkans as it maintained the institution of the small private property.
The methodology of this study uses the historical approach and is based on evaluation of secondary sources, but also in primary research by the author for the economic efficiency of agriculture. It uses also comparative analysis interpreting the social relations that existed in Greece and in the rest of the Balkans.
The paper is structured in four parts. The first refers to the history of the research objective. In the second and the third, economic and social differentiations are presented. In the fourth the above findings are evaluated.
Poland's Competitiveness in Foreign Trade in Apples
Authors: Trajer Marzena , Mieczkowski Martyn , Smoliński Paweł
Published: January 2023

Poland is one of the largest global producers and particularly exporters of apples. The export is of great importance to domestic producers of these fruits. The objective of the article was to assess Poland’s competitiveness in world trade in apples in the years 2003–2013. In connection with that, in an innovative way ten mutually complementary indices of ex-post competitiveness have been calculated for Poland and analysed. The study presents ranges in which the values of particular indices of competitiveness may be comprised. It also explains the impact which re-export may have on the levels of some of these indices, making it difficult for their correct interpretation. The studies have demonstrated that in the analysed period, Poland was characterised by high and growing competitiveness in foreign trade in apples, particularly in the years 2012–2013.
Stellar coronal mass ejections
Authors: Leitzinger M. , Odert P.
Published: January 2023

Stellar coronal mass ejections (CMEs) are a growing research field, especially during the past decade. The large number of so far detected exoplanets raises the open question for the CME activity of stars, as CMEs may strongly affect exoplanetary atmospheres. In addition, as CMEs contribute to stellar mass and angular momentum loss and are therefore relevant for stellar evolution, there is a need for a better characterization of this phenomenon. In this article we review the different methodologies used up to now to attempt the detection of stellar CMEs. We discuss the limitations of the different methodologies and conclude with possible future perspectives of this research field.
Historical and statistical aspects of risk groups analysis and testing in the context of gestational diabetes mellitus
Authors: Macura Maja , Dugalic Stefan , Todorovic Jovana , Gutic Bojana , Milincic Milos , Bozic Dragana , Stojiljkovic Milica , Soldatovic Ivan , Pantic Igor , Perovic Milan , Parapid Biljana , Gojnic Miroslava
Published: January 2023

In order to enhance cost-benefit value of the gestational diabetes mellitus screening (GDM) the concept of universal screening i.e., screening of all pregnant women for gestational diabetes, has mostly been abandoned in favor of the concept of selective screening. Selective screening implies that only women with risk factors are being screened for GDM. However, some recent studies have shown that with the application of the selective screening approach, some women with GDM may not receive proper and timely diagnosis. This review addresses the pros and cons of both concepts. It will also discuss screening methods and methods of preparation and performance of oral glucose tolerance test and the interpretation of its results.
On the Relation Between Exciton Dynamics and Nano-Morphology in Organic Semiconductor Blends
Authors:   , Riley Drew B.
Published: January 2023

Optoelectronic processes in semiconductor-based devices are widely understood through the constructs of highly-symmetric crystalline inorganic systems, where the lattice periodicity allows significant simplification. Emerging technologies, such as organic semiconductor-based devices, share many qualities with crys-talline inorganic semiconductors; however, they diverge in subtle yet important ways. Optical absorption in organic semiconductors gives rise to long-lived and tightly-bound excitons, which migrate in manner often disregarded in the un-derstanding of highly-symmetric crystalline inorganic semiconductors. Further, ‘free’ charge carriers in organic semiconductors ‘hop’ between organic molecules in a disordered film rather than the undergo band transport that delocalised car-riers in periodic lattices do. This hopping transport leads to lower charge carrier mobilities which have far-reaching ramifications to device operation.In the work summarised in this thesis the effect that excitonic and charge transport have on device performance of solar cells based on organic photo-voltaics will be explored. Experimental techniques are designed and developed to gain insight into the efficiency of exciton transport, the nanostructure of organic-semiconductor blends, and the relation between charge injection and extraction. Utilising these techniques, various state-of-the art systems are examined in detail and various pathways for improving device performance are voiced.Specifically, a technique to measure the exciton diffusion length in organic semiconductors is developed and shown to have many advantages over established techniques while improving the accuracy of the measurement. This technique is expanded to blends of organic semiconductors to quantify the efficiency of dif-fusion and quenching occurring between semiconductors in blends. This, along with a developed theoretical understanding, allows for the size of the phase sepa-rated domains to be quantified. Relationships between the excitons generated in organic semiconductors, charge carriers created in the blends, and the transport of charges to and extraction at the electrodes is considered in detail. Finally, a technique to distinguish between the nonradiative recombination occurring within an organic semiconductor blend and at the interface between the blend and the larger device structure is introduced. This technique utilises the well-establish reciprocity theory to reconcile the imbalance between charge injection and ex-traction unique to low-mobility organic semiconductors.
Nos passos do Concílio.
Authors: Leva José Ulisses
Published: January 2023

Nos passos do Concílio ... apresento os 45 anos da EN do papa São Paulo VI.
TEOLOGIA E DIREITOS HUMANOS A PESSOA COM DEFICIÊNCIA E AS INCLUSÕES POLÍTICAS SOCIAIS E NA IGREJA CATÓLICA
Authors: Rodrigues José Eduardo
Published: January 2023

RESUMOA Inclusão da Pessoa Com Deficiência na Igreja Católica, tema TCC do autor é uma reflexão investigativa sobre as legislações em seu processo histórico remetidos à inclusão da pessoa com deficiência na Igreja Católica em busca da sua santidade como outros cristãos no reino de Deus e na sociedade civil, sob o olhar das Sagradas Escrituras. Realizado, através de uma leitura da Campanha da Fraternidade/2019 com tema: “Fraternidade e políticas públicas”, enfatizando as políticas de inclusão incorporadas às políticas de Governo de Estado e religiosa com a DSI. A Igreja busca a santificação dos fiéis como modelo de vida, incluindo-se as pessoas com deficiência, “sede santos, porque Eu sou santo” Lv 11, 45. O Concílio Vaticano II salientou que todos os fiéis independente de qual for a sua condição ou estado são chamados ao Senhor sendo cada um por um caminho. Com o isolamento provocado pelo COVID-19 a sociedade demorou um pouco para lançar olhares para as pessoas com deficiência, porém, isto foi mitigado com os alertas realizado pela ONU e pelos órgãos que defendem a DSI.
QUESTÕES LITÚRGICAS EM TEMPOS DE PANDEMIA
Authors: Fernandes Veronice
Published: January 2023

Estamos passando por um “tempo emergencial”, por conta de doenças provocadas por coronavírus ou Covid-19 que levou a Organização Mundial da Saúde decretar uma pandemia.Esta nova situação obrigou governos do mundo tomarem medidas extraordinárias, algumas mais e outras menos restritivas, para conter ou mitigar seus efeitos sobre a saúde das pessoas, inclusive o fechamento de Igrejas. Sem a possibilidade de reunião presencial, tanto a Congregação para o Culto Divino e Disciplinas dos Sacramentos, como as Conferências Episcopais em cada país se pronunciaram, com orientações em relação ao modo de celebrar neste tempo particular, no intuito de resguardar a vida dos fiéis. As duas formas de celebrações mais utilizadas em tempos de pandemia foram e são ainda, onde o isolamento social continua, as celebrações eucarísticas (e outras) transmitidas por diversos meios de comunicação, como também as celebrações nas casas – Igreja doméstica. Neste artigo vamos tratar destas formas celebrativas, tendo como fundamento a natureza da liturgia definida pelo Concílio Vaticano II e alguns documentos pós Concílio.
A GRANDE COMISSÃO: BREVE ANÁLISE DE MATEUS 28:16-20 E O PROCESSO DE DESENVOLVIMENTO DOS DONS ESPIRITUAIS
Authors: Dos Santos Mauro Ribeiro
Published: January 2023

Este artigo abordará o tema da “grande comissão” conforme descrito na Bíblia Sagrada no livro de Mateus 28:16-20. O objetivo será extrair os elementos basilares da ordem de Jesus Cristo aos discípulos e destacar, dentre eles, os aspectos fundamentais do processo de discipulado cristão. Através de uma breve análise teológica, serão destacados os termos apresentados por Mateus buscando a compreensão objetiva desta ordem. Serão apresentados, também, alguns conceitos contemporâneos de discipulado com base nos “Dons Espirituais” descritos na Bíblia Sagrada nos livros de Efésios 4:11-13, Romanos 12:6-8, 1 Coríntios 12:8-11, 1 Coríntios 12:28 e 1 Pedro 4:11, objetivando mapear introdutoriamente o perfil ministerial embasado nas dádivas concedidas aos seres humanos para o desenvolvimento do serviço eclesiástico, aperfeiçoamento dos fiéis e cumprimento da missão evangélica.
GEODYNAMICS
Authors:   Istanbul Technical University, Batur Maryna , Babii Kateryna ,   M. S. Poliakov Institute of Geotechnical Mechanics of the National Academy of Sciences of Ukraine
Published: January 2023

The study analyzes the coordinate time series of five permanent International GNSS Service (IGS) stations located in New Zealand. It also considers their annual movement from 2009 to 2018. The raw data in the form of Receiver Independence Exchange (RINEX) files were taken from IGS database and processes by means of online processing service AUSPOS. Using coordinate time series, horizontal and vertical displacement rates were calculated covering the ten-year study period. According to the results, stations located at the North Island of New Zealand revealed an uplift of 31-32 mm/yr. At the same time, stations placed on the South Island showed the 21-22 mm/yr of positive vertical displacement. Regarding the horizontal displacements, their rates increase in North-South direction over the study region. In particular, two stations of North Island, located at the North-Western part, appeared in 24-25 mm/yr displacement, and one station at the Southern part of North Island showed the 35 mm/yr displacement rate. Stations, established at South Island, showed the horizontal displacement rates of 41-56 mm/yr. This research confirms the main contribution made to the field of crustal deformation studies, including the updated values of displacements along with their directions over the recent years. The results of this study can be used for further geodynamics investigations as well as for finding the most likely earthquake locations of the current study area.
Implementation of a rehabilitation program in a virtual reality for post-Covid-19 patients - preliminary results
Authors: Rutkowski Sebastian , Rutkowska Anna , Kirejczyk Lukas , Radosz Bartosz , Bogacz Katarzyna , Szczegielniak Jan
Published: January 2023

This study aims to present the preliminary results of a novel rehabilitation program for post-COVID-19 patients that incorporates virtual reality (VR). The study included 20 patients who had previously been affected by SARS-CoV-2 and participated in inpatient pulmonary rehabilitation. These patients were randomly divided into either a VR group or a control group. The both the VR group and the control group participated in the same rehabilitation program, which consisted of exercise capacity training on a cycle ergometer, breathing exercises, resistance and general fitness training, and relaxation. Each training component was performed once a day. The groups that participated differed based on the training settings they received on the cycle ergometer and relaxation training. The study assessed exercise tolerance (6MWT), lung function (FEV1, FVC, TLC, FEV1%VC), stress levels (PSS-10), quality of life (WHOQOL-BREF), likewise anxiety and depression symptoms (HADS). The results showed that the VR group had a statistically significant improvement in all of the functional capacity tests compared to the control group. The VR group also had a statistically significant improvement in quality of life compared to the control group. These results suggest that the inclusion of VR in rehabilitation programs may be beneficial for post-COVID-19 patients.
Examination of Complications and Differentiating Factors (Method of Conception, Nutritional Status, Weight Gain) in Twin Pregnancies
Authors: Karácsony Ilona , Deáki Laura , Pakai Annamária , Ferenczy Mónika
Published: January 2023

Introduction. The aim of our study was to examine the complications and differentiating factors (method of conception, nutritional status, rate of weight gain) of twin pregnancies. Methods. In our quantitative, cross-sectional, retrospective study we examined medical data sheets of women pregnant with twins (N=89) in the western regions of Transdanubia, Hungary. Results. Conditions occurring during pregnancy affected almost half of the mothers. Hypertension and preeclampsia are increased risk factors among the complications of twin pregnancies, independently of the method of conception (p>0.05). Abnormal weight gain during pregnancy was observed in half of the mothers. Weight before pregnancy is a strong predictor of weight gain during pregnancy (p<0.05). Conclusion. Our research showed that abnormal weight gain and obesity during twin pregnancy has a negative effect on maternal health, and correlates with maternal complications (hypertension/preeclampsia, gestational diabetes). Effective and preventative strategies are necessary, already during pregnancy planning, to prevent obesity before pregnancy.
A Study on Undergraduate Business Students’ EFL Learning Needs with a View to Studying and Working Abroad
Authors:   Alexandru Ioan Cuza University, Faculty of Economics and Business Administration, Iași, Romania, Alexa Oana Alexandra , Brânzilă Carina Ionela ,   Alexandru Ioan Cuza University, Faculty of Economics and Business Administration, Iași, Romania
Published: January 2023

A lot of headlines have been made over the last decades on the brain drain in Romania and elsewhere. We have seen a lot of our students leave the country right after graduating from university and many of them do not plan on returning in the near future. From the perspective of the professor teaching English to business undergraduates, this raises a few issues, from managing the students’ expectations and learning needs to adapting the course itself to a split reality. This paper discusses the findings of a small study conducted at the beginning of the 2022-2023 academic year among first- and second-year business students at the Faculty of Economics and Business Administration in Iași, as it tries to find out what plans they have for studying and/or working abroad in relation to their expectations and learning needs regarding (business) English courses.
TINJAUAN HUKUM ISLAM DAN HUKUM POSITIF TERHADAP ABORSI BAGI WANITA KORBAN PEMERKOSAAN
Authors: Ardina  , Nurinayah
Published: January 2023

This study aims to identify and analyze legal norms, especially those related to Islamic law and positive law in Indonesia regarding abortion as a result of rape. In general, the legal status of abortion according to Islamic law is haram. Likewise, it is found in article 346 of the Criminal Code that abortion is also not permitted. However, regarding the legal status of abortion caused by rape, there are several opinions in Islamic law and positive law in Indonesia. The research in this thesis uses normative juridical research (normative legal research), namely legal research conducted by examining literature or secondary data. In accordance with the characteristics of the study, this study used the library research method (literary study). The results of the study show that the legal status of abortion as a result of rape according to Islamic law has several opinions. The Tarjih Muhammadiyah Council forbids abortion as a result of rape, the Bahtsul Masail NU and the MUI fatwa allow it. Whereas in positive law in Indonesia as contained in Law Number 36 of 2009 concerning Reproductive Health both allow abortion due to rape.