bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical and radiological changes in acute hydrocarbon exposure in children
Authors:   Universitatea de Medicină și Farmacie „Carol Davila“, București, România, NIȚESCU Gabriela Viorela ,   Centrul Antitoxic Pediatric, Spitalul Clinic de Urgență pentru Copii „Grigore Alexandrescu”, București, România, BOGHIȚOIU Dora Andreea ,   Universitatea de Medicină și Farmacie „Carol Davila“, București, România,   Centrul Antitoxic Pediatric, Spitalul Clinic de Urgență pentru Copii „Grigore Alexandrescu”, București, România, SIMIONESCU Anca Angela ,   Universitatea de Medicină și Farmacie „Carol Davila“, București, România,   Departamentul de Obstetrică și Ginecologie, Spitalul Filantropia, București, România, NEMEŞ Roxana ,   Universitatea de Medicină și Farmacie „Carol Davila“, București, România, ULMEANU Coriolan Emil ,   Universitatea de Medicină și Farmacie „Carol Davila“, București, România,   Centrul Antitoxic Pediatric, Spitalul Clinic de Urgență pentru Copii „Grigore Alexandrescu”, București, România
Published: September 2021

Acute chemical poisoning is an important cause of morbidity and mortality for the pediatric population, with hydrocarbon exposure accounting for a significant share. The route of exposure but especially the type of hydrocarbons are responsible for the effect that these substances exert on the body and implicitly the clinical picture and an understanding of them is used in the care of the patient exposed to hydrocarbons. Objectives. Outlining the clinical and radiological profile of accidental acute hydrocarbon poisoning in children. Material and method. Medical documents of patients hospitalized in the Pediatric Antitoxic Center with a diagnosis of acute hydrocarbon intoxication over a period of 2 years were retrospectively analyzed, taking into consideration demographic characteristics, type of hydrocarbons, clinical manifestations and radiological changes. Results. 25 cases of acute hydrocarbon poisoning were identified in children. Exposure was only accidental by ingestion, with males and the 1-5 age group occupying the largest share. The main clinical manifestations were respiratory, gastrointestinal and nervous system and radiological changes were associated in only 20% of cases. Conclusions. Acute hydrocarbon poisoning in children are frequently asymptomatic or causes mild symptoms, dominated by gastrointestinal, respiratory and neurological manifestations. Pulmonary radiography is mandatory in paraclinical diagnoses but there is no correlation between the severity of the clinical picture and the radiological aspects. There may be situations in which symptomatic patients do not have radiological changes or situations with pathological radiological aspects in asymptomatic patients.
The assessment of the time-lapse between toxic exposure and examination in the Toxicology Department in pediatric severe acute poisoning
Authors:   Emergency Unit Department, ", ENACHE Cristina-Daniela ,   Grigore Alexandrescu",   Emergency Children's Hospital, Bucharest, Romania, VIVISENCO Cristina Iolanda ,   Department of Toxicology, "Grigore Alexandrescu" Emergency Children's Hospital, Bucharest, Romania,   Department of Pediatrics, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania, BOGHIŢOIU Dora Andreea ,   Department of Toxicology, "Grigore Alexandrescu" Emergency Children's Hospital, Bucharest, Romania,   Department of Pediatrics, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania, PETRAN Mădălina Elena ,   Department of Toxicology, "Grigore Alexandrescu" Emergency Children's Hospital, Bucharest, Romania,   Department of Biochemistry, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania, NIŢESCU Viorela Gabriela ,   Department of Toxicology, "Grigore Alexandrescu" Emergency Children's Hospital, Bucharest, Romania,   Department of Pediatrics, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania, ULMEANU Coriolan Emil ,   Department of Toxicology, "Grigore Alexandrescu" Emergency Children's Hospital, Bucharest, Romania,   Department of Pediatrics, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania, SIMIONESCU Anca Angela ,   Department of Obstetrics and Gynecology, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania,   Department of Obstetrics and Gynecology, Filantropia Clinical Hospital, Bucharest, Romania, DIMA Vlad ,   Department of Neonatology, Filantropia Clinica Hospital, Bucharest, Romania, STANCA Simona ,   Department of Toxicology, "Grigore Alexandrescu" Emergency Children's Hospital, Bucharest, Romania,   Department of Pediatrics, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania
Published: September 2021

The exposure of the pediatric population to xenobiotics is an important public health problem because children are particularly vulnerable to the unfavorable consequences of intoxications due to their age-related peculiarities, having limited physiological reserves, and poorly developed metabolic pathways. Numerous studies emphasize the importance of targeted therapeutic intervention and as soon as possible in patients with severe acute intoxications that associate signs of cardiogenic shock due to the severity of cases and the risk of adverse evolution. This paper presents a statistical analysis of the time-lapse impact between exposure to the toxicant and the toxicological examination on the patient's prognosis. Its purpose is to identify both qualitative and quantitative correlations between a series of parameters associated with unfavorable evolution and the time elapsed until the specific toxicological management is performed.
Interdisciplinary approach of a patient with Down syndrome
Authors:   Disciplina de Ortodonţie şi Ortopedie Dento-Facială, Facultatea de Medicină Dentară, Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, Trîmbiţaş Florina-Maria , Dragomirescu Anca-Oana ,   Disciplina de Ortodonţie şi Ortopedie Dento-Facială, Facultatea de Medicină Dentară, Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, Rădulescu Sergiu-Alexandru ,   Disciplina de Ortodonţie şi Ortopedie Dento-Facială, Facultatea de Medicină Dentară, Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, Ionescu Ecaterina ,   Disciplina de Ortodonţie şi Ortopedie Dento-Facială, Facultatea de Medicină Dentară, Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti
Published: September 2021

Down syndrome is a genetic disorder that occurs at an average frequency of 1 in 800 births. This syndrome, which develops as a result of the triplication of chromosome 21, is associated with characteristic facial features, mild to moderate intellectual disability, physical growth delays, characteristic facial features, low muscle tone. Orthodontic treatment in a patient with Down syndrome represents a real challenge, both in terms of the complex manifestations of this syndrome (whether they are systemic manifestations or strictly oral manifestations) and in terms of collaboration with specialists in other medical fields and more. This case illustrates the effectiveness of cooperation within the multidisciplinary treatment team and also the good collaboration with the pacient and especially with his parents.
SYMPHYSIS MORPHOLOGY AND DIMENSIONS IN DIFFERENT VERTICAL FACIAL PATTERNS (CBCT SCAN STUDY)
Authors:   Orthodontics and Dentofacial Orthopedic Department, Tishreen University, Lattakia, Syria, Mahfoud Mohamad , Hassan Hazem ,   Orthodontics and Dentofacial Orthopedic Department, Tishreen University, Lattakia, Syria
Published: September 2021

Mandibular symphysis (MS) morphology is a valuable diagnostic and treatment-planning tool in orthodontics. It is utilised as a reference measure for esthetic purposes, specifically in the lower part of the face, as well as to predict the direction of the mandibular growth rotation as the vertical growth direction. The aim of the presenting study is to use cone beam computed tomography (CBCT) to evaluate the MS morphology and dimensions of adults with different vertical facial patterns and had no previous orthodontic treatment. The study consisted of 100 subjects (42 males and 58 females). Mean age of subjects is 27.6 years (average age of men 29.2 years, average age of women 26.4 years). The CBCT images were obtained by Scanora 3D. The evaluation of the different vertical facial patterns was carried out according to Björk and Jarabak. Six lines, four angles and one area were used in the mandibular symphysis study. The study revealed varying correlations between the parameters of the mandibular symphysis and those of the vertical facial patterns. It was found that the convexity of the mandibular symphysis (B-POG-Me) and the distance from POG to the z-axis (POG-Z Axis) are highly correlated to the parameters evaluating the vertical facial patterns. The angle between the Gonion-Nasion line and the mandibular plane (GO2-Angle) and the angle between the palatal and mandibular planes (B-Angle) were highly correlated to the measurements used on the mandibular symphysis.
Comparative study of the prevalence of Angle Class II/1 and II/2 malocclusions in the area of Craiova
Authors:   Disciplina de Ortodonţie, Facultatea de Medicină Dentară, Universitatea de Medicină şi Farmacie Craiova, Dascălu Ionela Teodora , Diaconu Oana Andreea ,   Disciplina de Odontoterapie-Endodonţie, Facultatea de Medicină Dentară, Universitatea de Medicină şi Farmacie Craiova, Gheorghiţă Lelia Mihaela ,   Disciplina de Odontoterapie-Endodonţie, Facultatea de Medicină Dentară, Universitatea de Medicină şi Farmacie Craiova, Amărăscu Marina Olimpia ,   Disciplina de Morfologia Dinţilor şi Arcadelor Dentare, Tehnologia protezelor dentare,  Facultatea de Medicină Dentară, Universitatea de Medicină şi Farmacie Craiova, Coleş Evantia ,   Disciplina de Morfologia Dinţilor şi Arcadelor Dentare, Tehnologia protezelor dentare,  Facultatea de Medicină Dentară, Universitatea de Medicină şi Farmacie Craiova, Ţîrcă Tiberiu ,   Disciplina de Morfologia Dinţilor şi Arcadelor Dentare, Tehnologia protezelor dentare,  Facultatea de Medicină Dentară, Universitatea de Medicină şi Farmacie Craiova, Scrieciu Monica ,   Disciplina de Protetică Dentară, Facultatea de Medicină Dentară, Universitatea de Medicină şi Farmacie Craiova
Published: September 2021

We analysed the prevalence of Angle Class II/1 and Angle Class II/2 subdivisions both to boys and girls. In the researched group, the prevalence of Angle Class II malocclusion was of 17.65%, the first subdivision having values of 13.59% and the second one II/2 of 4.06%. In the case of the schoolchildren’s place of origin (urban/rural) we noticed that the number of Angle malocclusions subdivision II/1 was three times bigger than the subdivision II/2. For both subdivisions, the values of the prevalence were almost equal to boys and girls registering a slight variation to schoolchildren aged (6 to 10) and (11 to 14), both in the rural and the urban area.
CRANIAL BASE SYMMETRIC AND NORMAL LOWER JAW ROTATION
Authors:   Department of Orthodontics, Faculty of Dentistry, Tishreen University, Syria, Khwanda Mohamed , Jahjah Yazan ,   Orthodontics and Dentofacial Orthopedic Department, Dental School, Tishreen University
Published: September 2021

Understanding the complexities of cranial base development, function, and architecture is important for testing hypotheses about many aspects of craniofacial variation and evolution. Architecturally, the cranial base provides the platform upon which the brain grows and around which the face grows. In addition, the cranial base connects the cranium with the rest of the body: it articulates with the vertebral column and the mandible, provides conduits for all the vital neural and circulatory connections between the brain, the face and the neck, houses and connects the sense organs in the skull, and forms the roof of the nasopharynx. The shape of the cranial base is therefore a multifactorial product of numerous phylogenetic, developmental, and functional interactions. Aim. The aim of this research is to perform a morphometric analysis of the skull base to investigate the symmetry between the two hemibases of the cranial fossa with each other in adult patients with normal type of lower jaw rotation using cone beam copmuted tomography CBCT in transversal plane. Materials and methods. In result of radiographic study, 35 Caucasian adult patients with no prior orthodontics treatment were selected (16 males, 19 females) from 16 to 27 years (mean age of 20.02 years: females average age was 20.15 years; males average age was 21.84 years) of age with normal type of lower jaw rotation according to the sum of Björk. Pearson’s Correlation Coefficient was calculated to investigate the symmetry between the two hemibases of the cranial fossa with each other. Results. A difference was found amongst the two genders of the sample subjects in the strength of the correlation between the CBCT angular measurements evaluating the two hemibases of the cranial base symmetry. Conclusion. A difference was found amongst the two genders. This study found no exact symmetry between the samples, but it was in high level for adult females.
Methods used to assess the osseointegration of dental implants
Authors:   Departamentul de Implantologie Orală, Facultatea de Medicină Dentară, Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, Ciortea Claudiu , Cărămidă Mariana ,   Departamentul de Implantologie Orală, Facultatea de Medicină Dentară, Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, Sîrbu Ioan ,   Departamentul de Implantologie Orală, Facultatea de Medicină Dentară, Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti
Published: September 2021

The stability of dental implants is a prerequisite for osseointegration. Osseointegration is the process that involves the formation of bone around the dental implant, resulting in increased stability and its integration in the organism. Therefore, successful osseointegration contributes to a functionally optimal treatment. There is a need for a clinical method capable of measurement of bone quality at the time and following implant placement, to measure the degree of osseointegration and the ability of the implants to distribute loads to the surrounding bone. Research to date focuses on finding an ideal method to assess the osseointegration of dental implants in order to improve and broaden the clinical indications of dental implant systems. This paper aims to supply information about current methods used to assess the osseointegration of dental implants. In this regard, a literature review was conducted. Full-text scientific articles relevant to the chosen topic, written in English or whose text could be accessed in English were included.
Study of the apical leakage of the root canal filling made with Guttapercha versus Resilon
Authors:   Departamentul de Endodonţie, Facultatea de Medicină Dentară, Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, Perlea Paula , Nistor Cristina Coralia ,   Departamentul de Endodonţie, Facultatea de Medicină Dentară, Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, Suciu Ioana ,   Departamentul de Endodonţie, Facultatea de Medicină Dentară, Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, Aminov Liana ,   Departamentul de Endodonţie, Facultatea de Medicină Dentară, Universitatea de Medicină şi Farmacie „Grigore T. Popa“, Iaşi, Gheorghiu Irina ,   Departamentul de Odontoterapie Restauratoare, Facultatea de Medicină Dentară, Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, Iliescu Alexandru Andrei ,   Departamentul de Reabilitare Orală, Facultatea de Medicină Dentară, Universitatea de Medicină şi Farmacie Craiova
Published: September 2021

The purpose of the study is to assess the apical sealing ability of the endodontic space using two types of canal filling techniques: vertical compaction of warm gutta-percha and AhPlus sealer compared with Resilon and RealSeal SE. Two sets of extracted human teeth were prepared with rotary instruments, each 20 teeth being obturated by the two techniques: the classical and the adhesive root canal filling. The apical leakage of the root canal filling made with Resilon and RealSeal SE was higher than the one with gutta-percha and AhPlus. The difference was statistically significant.
The assessment of parents’ knowledge about toothbrushing of preschool children
Authors:   Disciplina de Pedodonţie, Facultatea de Medicină Dentară, Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, Munteanu Aneta , Luca Rodica ,   Disciplina de Pedodonţie, Facultatea de Medicină Dentară, Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, Farcaşiu Cătălina ,   Disciplina de Pedodonţie, Facultatea de Medicină Dentară, Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, Stanciu Ioana-Andreea ,   Disciplina de Pedodonţie, Facultatea de Medicină Dentară, Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, Farcaşiu Titus-Alexandru ,   Disciplina de Protezare Parţială Mobilizabilă, Facultatea de Medicină Dentară, Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti
Published: September 2021

Aim. To assess the knowledge of the preschool children’ parents about their toothbrushing. Material and method. During the first visit to the clinic, a questionnaire about the mother’ education level and children’ dental hygiene was given to the parents of 276 children aged 1 to 5 years, with caries in primary dentition. Results. a) 194 parents (70.29%) filled the questionnaire; b) in 15.46% of children (aged between 1 year 3 months and 3 years 3 months) the toothbrushing has not been yet introduced; most of the mothers with ≤10 classes started the toothbrushing after the age of 2 and mothers with middle and higher education level – in most cases after the age of 1; c) in 41.50% of children the toothbrushing was performed 1 time/day or less; d) 29.37% of children brushed their teeth without a parental surveillance and 48.75% with supervision. Conclusions. 1) Only in 5% of children toothbrushing was started before the age of 1; 2) About 30% of children had no parental supervision during their toothbrushing; 3) In a large percentage of mothers, especially those with lower education level, the knowledge about oral health care of preschool children are scarce.
Platelet rich fibrin (PRF) in oral implantology. Case study
Authors:   Facultatea de Medicină Dentară, Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, Tuţă Alexandra Mihaela , Sîrbu Valentin Daniel ,   Catedra de Reabilitare Orală, Facultatea de Medicină Dentară, Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, Sîrbu Ioan ,   Catedra de Implantologie Orală, Facultatea de Medicină Dentară, Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, Nichita Ştefan ,   Facultatea de Medicină Dentară, Universitatea de Medicină şi Farmacie „Titu Maiorescu“, Bucureşti
Published: September 2021

Dental implant therapy based on osseointegration has known a big expansion in dentistry in the last years. Dental implant rehabilitation is a common procedure in restoring partial or total edentulous pacients in our days. A problem regarding implant rehabilitation appears when the pacient doesn’t have enought bone to allow implant insertion in safety conditions. In this cases the clinician has to turn to complementary interventions in order to improve bone width and height so that implants could be inserted. One of the most known procedures is guided bone regeneration (GBR – guided bone regeneration) wich consists in placing a membrane to the bone defects. Platelet rich fibrin (PRF – platelet rich fibrin) is a second generation platelet concentrate wich gives the clinician access to growth factors throught a simple and up to date technology. These growth factors wich are autologous, non-toxic and non-immunogenic enhance and accelerate normal bone regeneration pathways. (1)
Statistic study regarding mandibular canal in dentate human specimens
Authors:   Disciplina Anatomie, Facultatea de Medicină Dentară, Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, Nimigean Victor , Sîrbu Valentin Daniel ,   Disciplina Reabilitare Orală, Facultatea de Medicină Dentară, Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, Nimigean Vanda Roxana ,   Disciplina Reabilitare Orală, Facultatea de Medicină Dentară, Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, Buţincu Lavinia ,   Disciplina Reabilitare Orală, Facultatea de Medicină Dentară, Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, Sălăvăstru Dan Ionuţ ,   Disciplina Anatomie, Facultatea de Medicină Dentară, Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, Poll Alexandru ,   Disciplina Reabilitare Orală, Facultatea de Medicină Dentară, Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, Ivaşcu Roxana ,   Disciplina Anatomie, Facultatea de Medicină Dentară, Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti
Published: September 2021

The major risk of dental implant treatment in the mandible is represented by the mandibular canal. Precise location of the mandibular canal is essential for oral rehabilitation with dental implants. The aim of this study was to analyze the topography of the mandibular canal in order to increase the long-term performance of oral rehabilitation with dental implants in „poor areas“. The topography of the mandibular canal was statistically studied on 11 human mandibles. The results obtained show similarities but also differences with data reported in other specialized references.
The spectrum of clinical manifestations of antiphospholipid syndrome
Authors:   Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, Diaconu Camelia C. ,   Clinica de Medicină Internă, Spitalul Clinic de Urgenţă Floreasca, Bucureşti, Dediu Giorgiana ,   Clinica de Medicină Internă, Spitalul Clinic de Urgenţă Floreasca, Bucureşti, Paraschiv Bianca ,   Institutul Naţional de Pneumologie „Marius Nasta“, Bucureşti
Published: September 2021

Antiphospholipid syndrome is an acquired autoimmune disease characterized by the appearance of thrombosis (venous, arterial and microvascular) and/or complications during pregnancy, in the presence of antiphospholipid antibodies. The clinical spectrum of the disease is now more complex and include organ-specific and systemic symptoms induced not only by thrombotic mechanisms, but also immune-mediated. Patients diagnosed with antiphospholipid syndrome should be evaluated clinically and laboratory periodically to detect lung damage, cardiac, neurological, skin, eye, hematological, gastrointestinal complications.
SERONEGATIVE ANTIPHOSPHOLIPID SYNDROME
Authors:   Department of Physiology, Faculty of Medicine, „Titu Maiorescu“ University, Bucharest, Cojocaru Manole ,   „Dr. Ion Stoia“ Clinical Center for Rheumatic Diseases, Bucharest, Cojocaru Inimioara Mihaela ,   Department of Neurology, „Carol Davila“ University of Medicine and Pharmacy, Bucharest,   „Prof. Gheorghe Marinescu“ Clinic of Neurology, Clinical Hospital Colentina, Bucharest, Chicos Bogdan ,   „Dr. Ion Stoia“ Clinical Center for Rheumatic Diseases, Bucharest
Published: September 2021

Seronegative antiphospholipid syndrome (seronegative APS) has remained an enigma and the concept is controversial. A small group of APS patients remain persistently negative for routine assays of antiphospholipid (aPL) antibodies. The clinical features are well defined, and include the tendency to both arterial and venous thrombosis, to recurrent miscarriages, and to occasional thrombocytopenia. Patients with clinical manifestations highly suggestive of APS but persistently negative conventional aPLs are classified as having seronegative APS.
Foreign body with multiple location – trachea, nose, cavum nasi – in a child. Case presentation
Authors:   Institutul Naţional de Neurologie şi Boli Neurovasculare, Bucureşti, Toader Corneliu ,   Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, Toader Mioriţa ,   Spitalul Clinic de Urgenţă pentru Copii „Grigore Alexandrescu“, Bucureşti, Vivisenco Iolanda Cristina ,   Spitalul Clinic de Urgenţă pentru Copii „Grigore Alexandrescu“, Bucureşti,   Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti
Published: September 2021

Pathology of tracheobronchial foreign bodies in children is a major emergency, because by their unpredictable evolution following mobilization, can cause sudden asphyxia. The most frequent location for airway foreign bodies is in the right primary bronchus, followed by the left primary bronchus and most rarely in the trachea. Sometimes in children, we can fi nd multiple airway foreign bodies. Very rare in children, we can fi nd airway foreign bodies with multiple location. The authors present a very rare case, unique in all pathology resolved along their quite vast experience – multiple foreign body with multiple location in the trachea, nose and cavum nasi in a child aged 1 year and 5 months.
The role of medical statistics in the study of clinical epidemiology and therapy of gastric cancer
Authors:   Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, Suliman Emine , Armean Petru ,   Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, Suliman Emel ,   Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, Palade Radu ,   Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti
Published: September 2021

Gastric cancer is among digestive tract cancers, the second as incidence, following as frequency after colorectal neoplasms. On a lot of 811 gastric cancer patients, hospitalized in SUUB in a period of five years (2010-2014), statistical analysis of casuistry highlights important elements regarding clinical epidemiology and therapeutics of this disease.
Pediatric case report: acute respiratory failure of initially unknown etiology
Authors:   Institutul Naţional de Neurologie şi Boli Neurovasculare Bucureşti, Toader Corneliu , Toader Mioriţa ,   Spitalul Clinic de Urgenţă pentru Copii „Grigore Alexandrescu“, Bucureşti, Mitea Gabriela ,   Spitalul Clinic de Urgenţă pentru Copii „Grigore Alexandrescu“, Bucureşti, Drăghici Mircea ,   Dentirad Hospital, Ploieşti, Şerbănică Andreea ,   Spitalul Clinic de Urgenţă pentru Copii „Grigore Alexandrescu“, Bucureşti, Oprea Alina ,   Spitalul Clinic de Urgenţă pentru Copii „Grigore Alexandrescu“, Bucureşti, Vivisenco Iolanda ,   Spitalul Clinic de Urgenţă pentru Copii „Grigore Alexandrescu“, Bucureşti
Published: September 2021

Acute respiratory failure represents a syndrome with a persistent high rate of mortality and morbidity among the pediatric population. Therefore, a rapid therapeutic intervention is of paramount importance. The frequent etiology in children is the occlusion of upper respiratory airways as a result of bronchospasm, foreign body or tumor. We present a case of a child with a sinusochoanal polyp of impressive dimensions which produced a symptomatology with acute onset. Sinusochoanal polyp are benign tumors which originate from paranasal sinuses with a frequency of 4-6% among nasal polyps, are solitary and occur especially in males. The case intrigues through its atypical debut and symptomatology, given the dimensions of the polyp.
Polymorphism of MTHFR gene (677 and 1298) in females with spontaneous abortions in Bihor County
Authors:   Compartimentul de genetică medicală, Spitalul Clinic Municipal „Dr. Gavril Curteanu“ Oradea, Kozma Kinga ,   Facultatea de Medicină şi Farmacie, Universitatea din Oradea, Jurca Claudia ,   Compartimentul de genetică medicală, Spitalul Clinic Municipal „Dr. Gavril Curteanu“ Oradea; Facultatea de Medicină şi Farmacie, Universitatea din Oradea, Bembea Marius ,   Compartimentul de genetică medicală, Spitalul Clinic Municipal „Dr. Gavril Curteanu“ Oradea; Facultatea de Medicină şi Farmacie, Universitatea din Oradea
Published: September 2021

Introduction. The MTHFR gene polymorphism is cited as a possible cause of spontaneous abortion. Aim. The genotype profile determination for the MTHFR (677 and 1298) gene and its correlations with spontaneous abortion in a female study group from Bihor County, Romania. Material and methods. This is a comparative research type conducted on a study group (SG) consisting of 46 female patients with a history of spontaneous abortions and a control group (CG) consisting of 50 females with no spontaneous abortions, no familial or personal history of thromboembolic events and who have had at least two previous live births. All women in both groups were genotyped for the MTHFR gene in positions 677 and 1298 by the Real-Time PCR method. Results. The proportion and the statistic significance of MTHFR 677/1298 genotype combinations found by us in the SG compared with the CG was, as follow: C677C/A1298A 2,17%, vs. 22% (p=0,01), C677T/A1298A 23,91%, vs. 20% (p=0,81), C677C/A1298C 21,73%, vs. 16% (p=0,61), C677C/C1298C 17,39%, vs. 4% (p=0,09), T677T/A1298A 13,04%, vs. 8% (p=0,51), C677T/A1298C 19,56%, vs. 28% (p=0,49), C677T/C1298C 2,17%, vs. 2% (p=1) and T677T/A1298C 0%, vs. 0% (p=1). Conclusion. The C677C/A1298A genotype combination (wild type/wild type) is in a significant higher percentage (p<0.05) in the control group compared to the study group, suggesting its protective role in producing spontaneous abortion. No other polymorphism of this gene has been statistically associated with spontaneous abortion.
TELEDERMATOLOGY: CONCEPTS AND APPLICATIONS IN MEDICINE
Authors:   IInd Department of Dermatology, Colentina Clinical Hospital, Bucharest, Romania, Constantin Maria-Magdalena ,   „Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania, Răducan Anca ,   IInd Department of Dermatology, Colentina Clinical Hospital, Bucharest, Romania, Poenaru Elena ,   „Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania, Constantin Traian ,   „Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania,   Urology Department, „Prof. Dr. Th. Burghele“ Clinical Hospital, Bucharest, Romania
Published: September 2021

Objectives. To assess the concepts of teledermatology (TD), a subspecialty of dermatology and one of the most common applications of telemedicine. Material and methods. This systematic review, totaling 32 works, is aimed to evaluate the advantages and limitations of teledermatology, which can be delivered in two ways: real-time (synchronous), using videoconference technology, and store-and-forward (SAF) methods (aynchronous), using digital images via internet, a cheaper and more convenient modality for the health care provider. Results. So far, teledermatology has been implemented in dermoscopy, dermatopathology and chronic wound care. However, other chronic skin disease, such as psoriasis, dermatitis, acne, rosacea and skin cancers can be evaluated and monitored using store-and-forward methods. Conclusions. In order to develop a teledermatology platform, Romanian dermatology requires specific protocols and equipment for taking and sending photographs. A dermatologist would then review the data using store-and forward method and respond with a diagnosis and therapeutic algorithm.
Dental students’ knowledge regarding hepatitis C
Authors:   Facultatea de Medicină Dentară, Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, Comănescu Cristian , Antipa Cristiana ,   Facultatea de Medicină Dentară „Titu Maiorescu“, Bucureşti, Rădulescu Sergiu ,   Facultatea de Medicină Dentară, Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, Andrei Cătălin ,   Facultatea de Medicină Dentară, Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, Pătraşcu Ion ,   Facultatea de Medicină Dentară, Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti
Published: September 2021

The present study, conducted in november 2015, with questionnaires completed by students in Bucharest Dental School at UMF „Carol Davila“ University, evaluates the attitude and general knowledge regarding Hepatitis C infection (VHC) (for students in the first years I and II) and specific knowledge after studying the matter Virology during college (middle and final years III to VI). 192 students were included in the study, the level of knowledge being evaluated by quntifying correct answers. Statistically significant data was obtained regarding wheather the students had or had not been studying Virology in the faculty curricula (p < 0.0001, mean 12-15, %CI = 11.03-15.43) and also regarding the age of the participants (p < 0.0001, mean 11-15, 95% CI = 9.128-17-73). By comparing the results between the 2 groups one can easily see an improovement of the knowledge level after studying Virology, proving that the scientifical, specialized information is a very efective way of making people aware and a way of prevention, both in the proffesional and in the private life of the future dentists.
The collaboration between the cardiologist and general practitioner – the key of post-myocardial infarction management
Authors:   Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, Scafa-Udrişte Alexandru , Tăutu Oana ,   Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, Zaharescu Carmen ,   Spitalul Clinic de Urgenţă Floreasca, Bucureşti, Bătăilă Vlad ,   Spitalul Clinic de Urgenţă Floreasca, Bucureşti, Tatu-Chiţoiu G.P. ,   Spitalul Clinic de Urgenţă Floreasca, Bucureşti, Dorobanţu Maria ,   Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti
Published: September 2021

The therapeutic strategy for a discharged patient who suffered a miocardial infarction implies a complexity of therapeutic measures and recommendations that guide the mid- and long-time outcome. A main factor of this process is represented by the thrust the patient has in the physician, physician being the person who prescribes and adjusts the treatment, and decides upon the investigations that need to be done. This is a dinamic process, the status of a patient who suffered a miocardial infarction being able to vary at any time during this evolution, especially in associated pathologies. The patient may be evaluated by multiple doctors, the therapeutic strategy being established by a cardiologist, general practitioner, or a team composed of cardiologist and general practitioner. However, the one who knows this best is the patient. This study is exclusively addressed to the patients (structured as a qestionnaire), future discussion being based on their answers. In this context, following the guideline recommandations concerning monitorization, recovery and the quality of life of the patient suffering from miocardial infarction, best result are obtained when the therapeutic strategy is established by a team formed from cardiologist and general practitioner.
Bio-psycho-social factors with occupational risk in Anesthesy and Intensive Care staff
Authors:   Spitalul Clinic de Urgenţă pentru Copii „Marie S. Curie“, Bucureşti, Sirghie Rodica Eugenia , Iamandescu Ioan Bradu ,   Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti
Published: September 2021

Profesional stress affects, among physicians, those who practise some medical specialities as oncology, neurosurgery, emergency medicine etc. and especially physicians of anesthesy intensive care units (AIC). Literature data concerning activity of AIC professionals evidentiate the high frequency of burnout syndrome, which may be considered as a first stage of a lot of troubles like behavioral, psychosomatic and psychiatrical ones. Daily distress encountered in AIC physicians and nurses is provoked mainly by the occupational pressure which cumulates the effects of many stressors, they are specific for this profession: overload (intensive and prolonged work – physically and psychically demanding, limited rest and sleep), high emotional tension (working with patients who are at the limit of life, time pressure, danger of severe drugs intolerance etc.), and some strong relational difficulties. These psycho-social stressors are not enough compensated during the recuperation period and act also in an aggravating manner on the frail personality wich is predisposed to anxiety, depression and psychosomatic pathology. After one presentation of general occupational distress, authors have synthesized the causes of burnout syndrome – specific for the AIC unities – and suggested the opportunity for a professional selection in the candidates for AIC speciality, based on psychodiagnostic evaluation.
Thyroid function in hearing impaired children with cochlear implant
Authors:   Spitalul Clinic de Urgenţă pentru Copii „M.S. Curie“, Bucureşti, Neagu Alexandra-Cristina , Gheorghiu Monica ,   Institutul Naţional de Endocrinologie „C.I. Parhon“, Bucureşti,   Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti
Published: September 2021

Congenital hypothyroidism may be associated with hearing loss. However, the prevalence of thyroid abnormalities in children with severe hearing loss is not clearly evaluated. The authors assessed the thyroid function in 30 children with profound sensorineural bilateral hearing loss, with cochlear implant, to determine if there is any association between congenital hearing loss and hypothyroidism. Serum levels of TSH and free thyroxine were normal in the study group. None had Pendred syndrome. We present a literature review on the association between hearing loss and thyroid abnormalities and the importance of testing hearing in children with congenital hypothyroidism.
Anticoagulant treatment after a bleeding event: between Scila and Caribda
Authors:   Universitatea de Medicină şi Farmacie „Carol Davila“ Bucureşti, Diaconu Camelia C. ,   Spitalul Clinic de Urgenţă Floreasca, Clinica de Medicină Internă, Bucureşti, Hostiuc Mihaela ,   Universitatea de Medicină şi Farmacie „Carol Davila“ Bucureşti,   Spitalul Clinic de Urgenţă Floreasca, Clinica de Medicină Internă, Bucureşti, Ilie Mădălina ,   Universitatea de Medicină şi Farmacie „Carol Davila“ Bucureşti,   Spitalul Clinic de Urgenţă Floreasca, Clinica de Medicină Internă, Bucureşti, Bălăceanu Alice L. ,   Universitatea de Medicină şi Farmacie „Carol Davila“ Bucureşti,   Spitalul Clinic de Urgenţă Sf. Ioan, Clinica de Medicină Internă, Bucureşti
Published: September 2021

Anticoagulant therapy is very important in preventing thromboembolic complications in a broad category of patients. When a bleeding event appears in anticoagulated patients, we should take into consideration the circumstances and the moment when the anticoagulant treatment should be resumed in patients who have an indication for temporary or permanent anticoagulation. This decision is often difficult. It should be weighted very carefully, on one hand, the thromboembolic risk of the patient, on the other hand the risk of recurrence of the recent bleeding event. The decision to resume the anticoagulant therapy depends also on the severity of the bleeding event, as well as the source of bleeding.
Surgical techniques used for tonsil disease in children
Authors:   Spitalul Clinic de Urgenţă pentru Copii „Grigore Alexandrescu“, Bucureşti, Zamfir-Chiru-Anton A. , Gheorghe D.C. ,   Spitalul Clinic de Urgenţă pentru Copii „M.S. Curie“, Bucureşti
Published: September 2021

The authors review the techniques described for the surgical treatment of the tonsils. Each new method has its own advantages and disadvantages. The difference can be evaluated by studying the intraoperative blood loss and safety of the procedure. Also, the postoperative complications and quality of life can be used as an adjunct to objectively appreciate the different surgical techniques. There is no literature consensus about the superiority of one technique over the other. Multiple studies brought multiple significant results. It is also hard to evaluate the entire panel of surgical methods described concomitantly. The experience of one surgeon and his/her mastering of a certain technique is the actual cause of so many surgical options still in use for tonsil treatment in children.
Cerebrospinal fluid fistula management – border pathology ENT-neurosurgery
Authors:   Institutul Naţional de Neurologie şi Boli Neurovasculare, Bucureşti, Toader Corneliu , Toader Mioriţa ,   Spitalul Clinic de Copii „Grigore Alexandrescu“, Bucureşti, Drăghici Mircea ,   Dentirad Hospital Ploieşti, Oprea Alina ,   Spitalul Clinic de Copii „Grigore Alexandrescu“, Bucureşti, Constantin Anca ,   Spitalul Clinic de Copii „Grigore Alexandrescu“, Bucureşti, Niculescu Liviu ,   Spitalul Clinic de Copii „Grigore Alexandrescu“, Bucureşti, Palade Dragoş ,   Universitatea de Medicină şi Farmacie „Gr. T. Popa“, Iaşi
Published: September 2021

The authors of this article mention the diagnostic methods, the surgery techniques and the postoperative care for the patients diagnosed with fistula of cerebrospinal fluid (CSF). The surgery cure depends on many factors, including here the etiology of the rhino-basis defect, intracranial pressure, anatomical location of the rhino-basis defect and it is strictly individualized, which depends on the success of all surgery procedures. ENT physicians, together with the neurosurgeons, were able to have a dominant role in the diagnostic evaluation and in the treatment of skull base pathology can give us a CSF fistula. Nasal endoscopy has revolutionized the treatment of CSF fistula, with a high rate of success.
Endocrine secondary hypertension
Authors:   Institutul Naţional de Endocrinologie „C.I. Parhon“, Bucureşti, Ghemigian A. ,   Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, Popescu I. ,   Institutul Naţional de Endocrinologie „C.I. Parhon“, Bucureşti, Petrova E. ,   Institutul Naţional de Endocrinologie „C.I. Parhon“, Bucureşti, Buruiană A. ,   Institutul Naţional de Endocrinologie „C.I. Parhon“, Bucureşti
Published: September 2021

The need to evaluate patients for secondary hypertension is common in clinical practice. Suspicion of endocrine hypertension occurs when the disease starts suddenly at young age, in cases with loss of blood pressure control in a patient with previously well-controlled blood pressure or labile blood pressure cases. Careful medical history and physical examination are very important to rule out other factors responsible for these patterns of hypertension (certain medications, alcohol, lack of compliance to treatment or dietary salt restriction, panic attacks etc). Pheochromocytoma and Cushing syndrome – the major endocrine diseases associated with secondary hypertension – are rare in clinical practice. Instead, primary hyperaldosteronism is becoming more frequently identified. It can go unnoticed because of nonspecific clinical presentation and of the fact that hypokalaemia, classically described, is actually rare in practice.
Burnei’s disease: teratological spondylolysis
Authors:   Clinica de Chirurgie şi Ortopedie Pediatrică „Prof. Dr. Alexandru Pesamosca“, Spitalul de Urgenţă pentru Copii „Maria Sklodovska Curie“, Bucureşti, Gavriliu Ştefan , Ghiţă Raluca ,   Clinica de Chirurgie şi Ortopedie Pediatrică „Prof. Dr. Alexandru Pesamosca“, Spitalul de Urgenţă pentru Copii „Maria Sklodovska Curie“, Bucureşti, Japie Ecaterina Maria ,   Clinica de Chirurgie şi Ortopedie Pediatrică „Prof. Dr. Alexandru Pesamosca“, Spitalul de Urgenţă pentru Copii „Maria Sklodovska Curie“, Bucureşti, Nayef Taysir El ,   Clinica de Chirurgie şi Ortopedie Pediatrică „Prof. Dr. Alexandru Pesamosca“, Spitalul de Urgenţă pentru Copii „Maria Sklodovska Curie“, Bucureşti, Macadon Mădălina ,   Clinica de Chirurgie şi Ortopedie Pediatrică „Prof. Dr. Alexandru Pesamosca“, Spitalul de Urgenţă pentru Copii „Maria Sklodovska Curie“, Bucureşti
Published: September 2021

Teratological spondylolysis is a pathological entity noted for the first time in the speciality literature by Gh. Burnei in „The Spine Journal“ on September 25th 2014. This disease was described in a short presentation of the first case treated by the author. The aim of this paper is to expose in a didactic manner the main characteristic aspects of Burnei’s disease: embryological, clinical, imaging and treatment data and also to make this pathological entity with all its pathognomonic diagnostic elements known. This paper is based on daata obtained after analysing 2 cases of teratological spondylolysis: a 18 years old patient with triple L3-L5 teratological spondylolysis with Pang 1 spinal dysraphism and a 1 year old child with teratological spondylolysis and retrospondylolisthesis.
THE ASO REACTION – CLINICAL USES AND LABORATORY METHODS
Authors:   „Carol Davila“ Central Military Emergency Hospital, Bucharest, Romania, Gireada Alexandra , Bacalbasa Nicolae ,   „Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania, Balescu Irina ,   „Ponderas“ Hospital, Bucharest, Romania
Published: September 2021

ASO reaction is one of the most commonly used laboratory tests especially due to the fact that Group A Streptococcal infection is a very often seen situation. Epidemiological studies have shown that ASO titers widely vary among different age groups and population groups; wide variations related to the moment of determination have been also reported.
Epidemiology of depression
Authors:   SCM Polimed APACA, Bucureşti, Patriche Diana , Filip Irina ,   Kaiser Permanente, California, SUA, Tănase Carmen ,   SCM Polimed APACA, Bucureşti
Published: September 2021

The World Health Organization estimates that depression is met in 350 million people. In the US, it was estimated in 2013 that 15.7 million people (6.7% of all US adults) had at least one major depressive episode in the previous year. A study conducted in 2012 at the European level (30 countries including Romania) showed that the average annual prevalence for major depressive disorder was 5.8%. In Romania in 2008 it was observed that the prevalence of major depressive episode in the examination was approximately 9% and over 21% during life. Significant statistical data showed that: depression is more common in women, it is often unrecognized or hidden by population and its economic impact is significant. Epidemiology of depression is needed to determine ways of identifying people at risk and improving their quality of life.
Maternal mortality rate in developed west-european countries
Authors:   Spitalul Clinic „Nicolae Malaxa“, Bucureşti, Gardescu Marrie Jeanne , Matei Alexandru ,   Spitalul Clinic „Nicolae Malaxa“, Bucureşti, Antoine Edu ,   Spitalul Clinic „Nicolae Malaxa“, Bucureşti, Nanu Dimitrie ,   Clinica de Obstetrică-Ginecologie „Bucur“, Bucureşti
Published: September 2021

The international medical organizations have as a main concern the maternal mortality in matter of finding solutions to diminish it. The maternal mortality rate in Romania has been decreasing in the last years. Even so it remains at a high level compared to the average rate recorded in this geographical zone. If in the developing countries, including our country, maternal mortality is deternined by hemorrhage, infection and complications of abortion, in developed countries the main cause of maternal mortality is represented by the complications of pregnancy induced hypertension.
Considerations on the quality of life in patients with dual diagnosis of depressive disorder and alcohol dependence
Authors:   SCM Polimed APACA, Bucureşti, Patriche Diana , Vasiliu Octavian ,   Spitalul Militar Central „Carol Davila“, Bucureşti, Filip Irina ,   Kaiser Permanente,California, SUA, Tănase Carmen ,   SCM Polimed APACA, Bucureşti, Radfar Amir ,   A.T. Still University, Mesa, Arizona, SUA
Published: September 2021

Quality of life is defined as the individual’s perception of his social, cultural value systems in the context in which one lives and in corelation with his needs, aspirations and standards (WHO, 1994). Patients with depression and alcoholism are associated with low scores on tests assessing quality of life. Quality of life assessment is useful for planning and evaluation of medical and psychological treatment outcomes.