bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparative Analysis of Efficacy and Prognosis of Hemodialysis and Peritoneal Dialysis for End-Stage Renal Disease: A Meta-analysis
Authors: Lu Jingyuan , Shi Danye , Zhao Xinhui , Xi Minhui , Qi Hualin , He Qiang
Published: March 2022

Objective. This meta-analysis is aimed at systematically assessing the efficacy and prognosis of hemodialysis (HD) and peritoneal dialysis (PD) in the treatment of end-stage renal disease (ESRD). Methods. China National Knowledge Infrastructure, VIP, SinoMed, Cochrane Library, PubMed, and Embase databases were searched for relevant studies to evaluate the two different dialysis methods for ESRD. The search time was set from 2010 to 2021. Meta-analysis was performed using Stata16.0. The treatment group received PD, while the control group was given HD. Results. Out of 317 articles initially retrieved, 14 studies were finally included in our meta-analysis. The analysis results showed that there was no marked difference in the 1-year survival rate between the two groups (

RR
=
1.05

; 95% CI: 1.00, 1.10;

P
>
0.05

), but the incidence rate of adverse reactions in the treatment group was significantly lower than that in the control group (

RR
=
0.51

; 95% CI: 0.37, 0.70;

P
<
0.05

). In addition, PD and HD treatments caused significant decreases in serum creatinine levels (PD,

SMD
=
−
2.91

; 95% CI: -3.79, -2.04;

P
<
0.05

; HD,

SMD
=
−
3.09

; 95% CI: -4.01, -2.16;

P
<
0.05

) and blood urea nitrogen levels (PD,

SMD
=
−
2.54

, 95% CI: -3.37, -1.72,

P
<
0.05

; HD,

SMD
=
−
2.62

, 95% CI: -3.47, -1.77,

P
<
0.05

); however, there was no significant statistical difference in posttreatment levels of serum creatinine and blood urea nitrogen between the two groups. Compared with the control group, the hemoglobin (

SMD
=
0.56

, 95% CI: 0.07, 1.06;

P
<
0.05

) and serum albumin (

SMD
=
1.11

, 95% CI: 0.46, 1.76,

P
<
0.05

) levels were significantly increased in the treatment group after treatment. Conclusion. In summary, both PD and HD can improve renal function in uremic patients, but PD is superior to HD in reducing the incidence of adverse reactions, improving the nutritional status, and therefore improving the quality of life of patients.
Fault-Tolerant Relay Node Placement in Wireless Sensor Networks for Surveillance of Overhead Transmission Lines
Authors: Wang Kaixuan , Yang Jian
Published: March 2022

Wireless sensor networks provide a promising technology to surveil overhead transmission lines in smart grid communication. However, a great challenge for researchers is proposed by adverse outdoor environments and essential requirements of strong as well as flexible smart grid communication. Specifically, nearly linear topology, limited energy, and tolerance for faults are entangled to make the surveillance system complex. Because of the need for deep understanding of system, significant efforts have been made in the past few years. We have proposed a fault-tolerance framework for surveillance of overhead transmission lines. In this paper, we follow the framework and further explore deployment problems systematically. Firstly, we present a fault-tolerance placement model. After analyzing the model, we identify the optimal placement for fault tolerance and then propose a placement algorithm with optimal deployment. An extensive experiment highlights some useful observations for design of the fault-tolerance system and demonstrates efficient fault tolerance for relay nodes. Numerical results show that the fault-tolerance ratio is improved by at least

6
%

compared to that of previous algorithms.
Mortality Associated with Recurrent Extreme Hyperferritinemia in Critically Ill Adolescents
Authors: Baird John Scott
Published: March 2022

Introduction. Recurrent extreme hyperferritinemia (ferritin >10,000 ng/mL) was noted in 4 critically ill adolescents prior to death, though this association has not previously been described. Methods. A retrospective review of the medical records of 4 critically ill adolescents with recurrent extreme hyperferritinemia and systemic inflammation was performed to identify additional common epidemiologic factors. Results. Systemic inflammation was characterized as cytokine storm syndrome in 2 patients and hemophagocytic lymphohistiocytosis in 2 patients. Episodes of extreme hyperferritinemia were noted on at least 2 different dates in all patients; these episodes (n = 10) were separated by an interval of 2 weeks to several months and were usually (in 8 of 10 episodes) associated with the onset or worsening of multiple organ dysfunction syndrome. Death occurred within 2 weeks of the onset of an episode of recurrent extreme hyperferritinemia. Lymphocytopenia and cachexia were noted in all patients. Conclusions. Recurrent extreme hyperferritinemia—often with multiple organ dysfunction syndrome—was noted in 4 adolescents with systemic inflammation who did not survive their critical illness. Recurrent extreme hyperferritinemia may be a novel biomarker of increased mortality in patients with the syndrome of persistent inflammation, immunosuppression, and catabolism.
Active Peripheral Osteoma in the Mandibular Notch: A Longitudinal Clinical Report
Authors: Sasaki Jun , Hasegawa Shogo , Miyachi Hitoshi , Nagao Toru
Published: March 2022

Osteomas are benign osteogenic tumors composed of mature compact or cancellous bone and are characterized by slow, painless growth. A peripheral osteoma located in the mandibular notch is extremely rare. Here, we describe the case of a 38-year-old woman with an active peripheral osteoma in the mandibular notch for long-term follow up. Surgical resection of the lesion was performed, which resulted in the improvement of the mandibular function and temporomandibular dysfunction. This is the first report of resection surgery after confirming the activity of peripheral osteoma by bone scintigraphy. Creating a three-dimensional model of the mandible promises an accurate surgical plan.
A Model of Urban Economic Resilience Development with Multisource Data Fusion
Authors: Xia Juzi
Published: March 2022

Taking a city as an example, a city physical examination index system is built around 8 aspects, including ecological livability, health and comfort, safety and resilience, and convenient transportation. Using the normalization method and hierarchical analysis method, we calculate and evaluate the natural background and operation of the city. The overall urban living environment is good, the ecological livability and neatness and orderliness of the city are high, the construction of convenient transportation and safety resilience needs to be strengthened, and there is still room for improvement in terms of style characteristics, health and comfort, innovation and vitality, diversity and tolerance, etc. The population density, the number of good air quality days, and the mortality rate of 10,000 vehicles in the urban center of the city are the highest. According to the results of the multisource urban health check, the city needs to take the problems and needs as the guide to accurately manage the “urban diseases” in the future and strive to improve the satisfaction, happiness, and sense of belonging of urban residents.
Molecular Docking and Molecular Dynamics Simulation of Fisetin, Galangin, Hesperetin, Hesperidin, Myricetin, and Naringenin against Polymerase of Dengue Virus
Authors: Fatriansyah Jaka Fajar , Rizqillah Raihan Kenji , Yandi Muhammad Yusup
Published: March 2022

Dengue fever is a disease spread by the DENV virus through mosquitoes. This disease is dangerous because there is no specific drug, vaccine, or antiviral against the DENV virus, insisting on drug discovery for dengue fever. RNA-dependent RNA polymerase (RdRp) enzyme in DENV can be a drug target because it has an important role in the virus replication process. In this research, in silico simulations were carried out on bioflavonoid compounds, namely, Fisetin, Galangin, Hesperetin, Hesperidin, Myricetin, and Naringenin with Quercetin as control ligand. QSAR analysis showed that all ligand has the probability to be antiviral and RNA synthesis inhibitor. Docking scores showed that Myricetin, Hesperidin, and Fisetin show strong performance while Hesperidin, Hesperetin, and Naringenin showed strong performance in MM/GBSA. Only Hesperidin showed strong performance in both scorings. Further investigation by ADMET analysis was done to investigate toxicology and pharmacological properties. Our molecular dynamics study through RMSD showed that even though Quercetin does not give good scoring values in both docking score and MM/GBSA, it has robust stable interaction to RdRp. The strong performance of Hesperidin was also validated by protein-ligand contact fraction in 5 ns. Overall, we observed that Hesperidin shows good potential as a DENV-3-RdRp inhibitor in par with Quercetin, although further in vitro study should be conducted.
Interactive Music Instructional Mode Based on Cloud Computing
Authors: Tian Hong
Published: March 2022

The interactive music education in cloud computing environment is designed to address the disadvantages of traditional music instructional mode. The content of interactive music education is investigated using cloud computing technology. The database of interactive teaching automation grouping platform is generated based on the basic learning information of learners in the data, and it is used to provide instructional resources and basic technical support. On this foundation, the automatic grouping algorithm is introduced to enable interactive teaching to be automatically grouped. The new music instructional mode, which incorporates IT into interactive music education, not only aids students in better understanding instructional content and mastering the inherent laws of the knowledge they have acquired but also significantly improves upon the traditional music instructional mode’s flaws. The results of the tests show that this method is extremely precise. And the designed platform has a better learning effect on students, indicating that the designed interactive music education platform has some practical application value.
The Low-Carbon Effect Measurement of the Structural Adjustment of the Ice and Snow Industry Based on Artificial Intelligence
Authors: Sun Weibo , Du Hongbo , Li Jialin , Jiao Yufeng , Liu Lei
Published: March 2022

Ice and snow economy is an economy characterized by ice and snow, and its foundation is ice and snow resources. The ice and snow economy covers the tertiary industry of ice and snow activities, and its core power comes from ice and snow tourism, which promotes the common development of manufacturing, transportation, catering, retail, and other industries. This paper studies the low-carbon effect measurement analysis of the structural adjustment of the ice and snow industry based on artificial intelligence, which proves that the economic benefits and carbon emissions of the structural adjustment of the ice and snow industry will be greatly improved after the addition of artificial intelligence technology. For this research, a series of investigation experiments are conducted, and the ice and snow industry in Heilongjiang Province is selected for analysis. First, the important position of artificial intelligence technology in today’s information society and its practicality are fully analyzed, and then its feasibility in combination with the structural adjustment of the ice and snow industry is analyzed. Second, it analyzes the characteristics of the structural adjustment of the ice and snow industry while taking into account its requirements for measuring low-carbon effects. The mathematical model of industrial structure optimization based on low-carbon constraints is adopted in the application model of artificial intelligence technology in the adjustment of the ice and snow industry structure, and the effects of carbon emissions before and after structural adjustments in the ice and snow industry are calculated to achieve a better industrial structure adjustment plan. Experimental data shows that with the help of artificial intelligence in the process of structural adjustment of the ice and snow industry, the average income of residents has increased by nearly 7%, and the transformation of the ice and snow industry’s contribution to the reduction of carbon emissions has rapidly increased to 12.24%.
Comparison of Clinical Effects of Temozolomide Single Agent and Combined Doxorubicin in the Treatment of Glioma
Authors: Liu Yibo , Chen Ligang
Published: March 2022

In this article, we have compared and analyzed the clinical effects of temozolomide single agent and combined doxorubicin in the treatment of glioma. To evaluate this, a total of 70 patients diagnosed with glioma in our hospital from July 2019 to July 2020 were randomly divided into two groups, the observation group and the control group, with 35 patients in each group. The control group received temozolomide capsules orally. The observation group was treated with temozolomide single agent and doxorubicin. After treatment, the clinical efficacy, adverse reactions, and KPS score of the two groups were observed. After treatment, the total response rate of the control group was 31.43%, and the total response rate of the observation group was 62.86%. The difference between the two groups was statistically significant (

P
<
0.05

). Before treatment, there was no significant difference in KPS scores between the two groups (

P
>
0.05

). After treatment, the KPS scores of both groups were improved, and the KPS scores of the observation group and the control group were significantly better, with statistical significance (

P
<
0.05

). In the observation group, 17 cases had adverse reactions, including 10 cases of nausea and vomiting, 2 cases of leucopenia, and 5 cases of thrombocytopenia, with a total incidence of 48.57%. In the control group, there were 31 cases of adverse reactions, including 22 cases of nausea and vomiting, 6 cases of leucopenia, and 4 cases of thrombocytopenia, with a total incidence of 91.43%. The difference between the two groups was statistically significant (

P
<
0.05

). The efficacy of temozolomide single agent and combined doxorubicin in the treatment of glioma was significant. Moreover, it can significantly improve clinical efficacy, reduce the incidence of adverse reactions, and improve the health status of patients, which is worthy of further clinical application.
Evaluation Model of Student Satisfaction in International Student Education Based on Neural Networks
Authors: Wang Zhisong , Gao Shuhong
Published: March 2022

Artificial neural network (ANN) theory is a rapidly developing information science around the world. The Back Propagation (BP) network is one of many artificial neural network types. It is a multilayer feedforward network with sophisticated nonlinear mapping capabilities. It is actually a relatively complex and nonlinear comprehensive decision-making problem when taking into account the comprehensive evaluation of test scores based on evaluation indicators that reflect the quality of the test papers. The five major factors of education service quality are tentatively proposed in this paper, which uses a neural network to model and analyze it. This paper examines the five factors of the education service quality evaluation model one by one and analyzes the issues that exist in the education service quality of international students in China. According to empirical research, overall satisfaction with the quality of education service in Guangxi among foreign students in China is low, and subindicators of education service quality are unbalanced. This paper analyzes the reasons for this situation from the three levels of service consciousness, emotional investment, and professional quality and proposes that the main task of improving education service quality is to optimize the entire service process, in order to narrow the gap between foreign students’ expectations and actual perceptions of educational services.
Organizational Climate, Innovation Orientation, and Innovative Work Behavior: The Mediating Role of Psychological Safety and Intrinsic Motivation
Authors: Xu Ziqing , Wang Huilin , Suntrayuth Sid
Published: March 2022

Nowadays, many high‐tech SMEs have gradually focused on innovation‐orientation and have adopted various measures to create an organizational climate, stimulate knowledge workers’ enthusiasm for innovation, and promote individual innovation behavior, but met with little success. Based on the stimulus organism response (SOR) model, the objective of this study is to explore the mediating factors that affect knowledge workers’ innovative work behavior, and construct a three‐level model of the external environment, psychological factors, and individual behavior. This study selected 575 valid samples from 24 high‐tech SMEs in Zhongguancun, which is a technology hub in Haidian District, Beijing, China. Through the convenience sampling method, This study analyze the data and perform structural equation modeling (SEM) using AMOS 23.0. The external environment (i.e., organizational climate, innovation orientation) and psychological factors (i.e., intrinsic motivation, psychological safety) have a significant positive impact on innovative work behavior. Psychological factors have the most significant impact on innovative work behavior. Besides, psychological factors also mediate the relationship between the external environment and innovative work behavior. The findings indicated that high‐tech SMEs need to formulate scientific innovation‐orientation when implementing strategies, and continue to shape a harmonious and equal organizational climate. Furthermore, high‐tech SMEs should encourage knowledge workers to speak the truth, express different voices, and stimulate work enthusiasm to improve psychological safety and intrinsic motivation, thereby enhancing knowledge workers’ innovative work behavior.
A Novel Prognostic Ferroptosis-Related lncRNA Signature Associated with Immune Landscape in Invasive Breast Cancer
Authors: Shen Shuang , Yang Danhe , Yang Yumin , Chen Yanqi , Xiong Jing , Hu Xiaochi
Published: March 2022

Breast cancer (BC) represents the most common form of malignant tumors in women. However, the effectiveness of BC immunotherapy remains very low. Ferroptosis is a recently described form of programmed cell death which has unique characteristics, and associated long-chain noncoding RNAs (lncRNA) are thought to influence the occurrence and development of a variety of tumors. We identified 1,636 lncRNAs associated with ferroptosis in BC patients. 299 differentially expressed ferroptosis-related lncRNAs were subjected to univariate, LASSO regression, and multivariate Cox regression analyses to construct a ten ferroptosis-related lncRNA signature. This ten ferroptosis-related lncRNA signature performed very well in predicting survival of BC patients, and the risk score of the mRNA signature was identified as an independent prognostic factor in this cancer entity. In addition, the signature could be used to predict the immune landscape of BC patients. Low-risk patients had enriched immune-related pathways and more infiltration of most types of immune cells. The signature was also associated with the tumor mutation burden in BC. The results have allowed us to assess the potential for immunotherapy targets exposed by this model. The ferroptosis-related lncRNA risk model reported in the current study has clinical utility in BC prognosis and predicted immunotherapy response.
Research on Mental Health of Migrant Children Based on Wireless Communication Detection Technology
Authors: Jiang Ziyun , Ma Xuejia
Published: March 2022

The current domestic survey of children in large and medium cities shows that the mental health of children in my country is generally not optimistic, and the mental health problems are worsening year by year. Due to the lack of research on the mental health of migrant children, the purpose of this paper is to study the mental health of migrant children based on computer technology. Methods. According to the definition of migrant children and psychological problems, the functional requirements of the system were analyzed, and a mental health assessment system for migrant children with advanced technology, safe data management, and efficient information management was established. The server uses the most secure WINDOWSXP operating system and large-scale distributed SQL server database for database management. Taking the students from the sixth grade to the ninth grade of the compulsory education M primary school as the survey objects, the mental health problems of their stores were analyzed. The experimental results showed that compared with children in other grades, migrant children in grade 9 were significantly more sensitive and impulsive.
Research on Travel Reimbursement Behavior Management Based on Deep Learning in Financial Sharing Mode
Authors: Zhang Qian , Feng Bowei
Published: March 2022

The standardization, transformation and upgrading of financial management plays an important supporting role in promoting the standardized management and healthy operation of corporate expense reimbursement behaviors. This paper starts with the behavioral portrait of enterprise personnel travel expense reimbursement. Based on the problems of lengthy process and complex financial accounting in most reimbursement behaviors at this stage, an efficient and efficient expense reimbursement processing method is proposed, that is, reimbursement through collection Information images, using the convolutional neural network algorithm under deep learning, to detect target images and identify valid information, and rely on the financial shared service center's screening function of expense reimbursement behavior portraits under big data, the integrity of expense reimbursement data. Compliance is judged, thus forming a complete set of standardized and procedural personal self-service reimbursement model, which optimizes the management of enterprise expense reimbursement behavior, avoids subsequent losses and resource waste caused by human risks, and improves enterprise operation efficiency and expenses. Control has certain value and reference significance.
The Effects of the Task Balance Training Program on the Glial Cell Line‐Derived Neurotrophic Factor Levels, Cognitive Function, and Postural Balance in Old People
Authors: Abdullah Meutiah Mutmainnah , Sinrang Andi Wardihan , Aras Djohan , Tammasse Jumraini
Published: March 2022

Exercise in the form of physical activity can provide neuroprotective benefits. The purpose of this study is to determine the effect of the task balance training program (TBT program) on the glial cell‐derived neurotrophic factor levels, cognitive function, and postural balance in old people. The population of this study was the old people members of the Batara Hati Mulia Gowa Foundation who were willing to participate in the study (n = 66). The sample of this study was obtained through a random sampling technique to determine the treatment (n = 32) and control (n = 34) groups. Before and after implementing the TBT program, glial cell‐derived neurotrophic factor (GDNF) level measurement and cognitive function and postural balance assessment were performed. Cognitive function was measured by using Montreal cognitive assessment (MoCA). Postural balance was measured in two ways by using the timed up and go (TUG) test and Tinetti performance‐oriented mobility assessment (POMA). The treatment group showed significantly greater changes than the control group in GDNF levels (2.24 (±0.63) vs. 1.24 (±0.43), P = 0.001), cognitive function (24.66 (±3.42) vs. 19.18 (±2.67), P = 0.001), and postural balance (TUG [14.00 (±4.04) vs. 18.68 (±3.98)]; POMA [26.53 (±1.74) vs. 23.47 (±3.06)], P = 0.001) after training. The treatment group also showed a significant relationship between GDNF levels and cognitive function (r = 0.840, P = 0.001) and postural balance (TUG [r = 0.814, P = 0.001]; POMA [r = 0.630, P = 0.001]). The TBT program affects the levels of GDNF in old people. The TBT program involves cognitive function improvement and affects postural balance changes in old people.
Synthesis and Characterization of Activated Carbons Prepared from Agro-Wastes by Chemical Activation
Authors: Njewa Joel Brian , Vunain Ephraim , Biswick Timothy
Published: March 2022

In this present study, activated carbons were prepared from rice husks and potato peels by chemical activation with 40% phosphoric acid (H3PO4). The effects of carbonization temperature and impregnation ratio were investigated with a continuous activation period. Physicochemical characteristics such as surface morphology, surface charge, and surface functional groups were assessed. According to X-ray diffraction measurements, the results showed that the activated carbons had identical pHpzc (6.8) and that the activated carbons generated were carbonaceous. The existence of hydroxyl, carbonyl, amines, aromatic, and other functional groups, which are excellent for adsorption, was revealed by surface chemistry studies. Micrographs taken with a scanning electron microscope indicated wide opening pores with a larger mesoporous surface area and many linked pores. Rice husk activated carbon outperformed potato peel activated carbon in laboratory tests. The research has shown that the agro-wastes employed in the study are possible precursors for making locally activated carbons at a low cost, thus resolving the problem of agro-waste disposal.
Stromal FAP Expression is Associated with MRI Visibility and Patient Survival in Prostate Cancer
Authors: Pellinen Teijo , Sandeman Kevin , Blom Sami , Turkki Riku , Hemmes Annabrita , Välimäki Katja , Eineluoto Juho , Kenttämies Anu , Nordling Stig , Kallioniemi Olli , Rannikko Antti , Mirtti Tuomas
Published: March 2022

Some clinically significant prostate cancers are missed by MRI. We asked whether the tumor stroma in surgically treated localized prostate cancer lesions positive or negative with MRI are different in their cellular and molecular properties, and whether the differences are reflected to the clinical course of the disease.

We profiled the stromal and immune cell composition of MRI-classified tumor lesions by applying multiplexed fluorescence IHC (mfIHC) and automated image analysis in a clinical cohort of 343 patients (cohort I). We compared stromal variables between MRI-visible lesions, invisible lesions, and benign tissue and assessed the predictive significance for biochemical recurrence (BCR) and disease-specific survival (DSS) using Cox regression and log-rank analysis. Subsequently, we carried out a prognostic validation of the identified biomarkers in a population-based cohort of 319 patients (cohort II).

MRI true-positive lesions are different from benign tissue and MRI false-negative lesions in their stromal composition. CD163+ cells (macrophages) and fibroblast activation protein (FAP)+ cells were more abundant in MRI true-positive than in MRI false-negative lesions or benign areas. In MRI true-visible lesions, a high proportion of stromal FAP+ cells was associated with PTEN status and increased immune infiltration (CD8+, CD163+), and predicted elevated risk for BCR. High FAP phenotype was confirmed to be a strong indicator of poor prognosis in two independent patient cohorts using also conventional IHC.

The molecular composition of the tumor stroma may determine whether early prostate lesions are detectable by MRI and associates with survival after surgical treatment.

Significance:

These findings may have a significant impact on clinical decision making as more radical treatments may be recommended for men with a combination of MRI-visible primary tumors and FAP+ tumor stroma.
Association of Anemia with Dementia and Cognitive Decline among Community-Dwelling Elderly
Authors: Weiss Avraham , Beloosesky Yichayaou , Gingold-Belfer Rachel , Leibovici-Weissman Yaara , Levy Yochai , Mulla Farhan , Issa Nidal , Boltin Doron , Koren-Morag Nira , Meyerovitch Joseph , Sharon Eran , Schmilovitz-Weiss Hemda
Published: March 2022

Introduction: The association of anemia with dementia in elders is controversial. We examined the potential association of anemia with dementia in a large population of elders. Methods: Historical-prospective registry-based study. Included 36,951 community-dwelling elders (65–113 years) that were followed during 2002–2012. Anemia of all kinds was defined according to Clalit Health Services (CHS) definitions: hemoglobin (HGB) <14 g/dL men, <12 g/dL women; and World Health Organization (WHO): HGB <13 g/dL men, <12 g/dL women. Anemia was categorized as mild (HGB 11–13 g/dL men, 11–12 g/dL women) or moderate-severe (HGB <8–10.9 g/dL men and women). Background data, laboratory values, and diagnosis of dementia and cognitive decline (DCD) were reviewed. Results: During the 10-year follow-up period, DCD was newly diagnosed in 7,180 subjects (19.4%). Subjects with DCD had a higher rate of anemia than those without DCD. Time to development of DCD was 1.5 years shorter in those with than without anemia. On multivariate Cox regression analysis adjusted for age and sex, the hazard ratio (HR) for DCD was 1.45 (95% CI: 1.37–1.54) by CHS and 1.51 (95% CI: 1.41–1.61) WHO anemia criteria. The more severe the anemia, the greater the risk of DCD development (HGB 13–14 g/dL [men only], HR = 1.20 [95% CI: 1.09–1.32]; mild anemia, HR = 1.38 [95% CI: 1.28–1.49]; moderate-severe anemia, HR = 1.64 [CI: 1.41–1.90]). Every decrease in 1 standard deviation of HGB (1.4 g/dL) increased the DCD risk by 15%. A competing risk model has weakened the association of anemia with DCD risk. Conclusions and implications: Anemia in community-dwelling elders appears to be associated with an increased DCD risk in a dose-response manner. Application of the WHO anemia criteria in men may miss patients with mild anemia that places them at DCD risk. Further research should look at anemia as a cause of reversible dementia.
Gifted students' number sense skills in terms of number sense components
Authors: Er Zübeyde , Artut Perihan Dinç
Published: March 2022

As a descriptive survey research, this study aimed to investigate the number sense skills of gifted in terms of number sense components. Participant of this research consisted of 123 gifted secondary school students, who were selected according to the convenience sampling method in Turkey. The data of this research were collected in the 2021-2022 academic year. The number sense test was used as the data collection tool. This test is comprised of 20 items which were prepared in line with five basic number sense components. The data obtained from the data collection tool were analysed by quantitative analysis methods. As a result of the analysis, it was confirmed that the number senses of gifted secondary school students differed according to gender and this difference was in favour of the male students. The highest number sense performance according to grade levels belonged to eight grade level students. Furthermore, it was observed that the number sense performance increased in parallel with the grade levels of the students. In addition, when the mean of correct answers for the number sense components was considered, it was concluded that the highest mean was in the understanding of the effect of the operation and the lowest mean was in the understanding of the number concept, respectively.
STEM literacy in growing vocational school student HOTS in science learning: A meta-analysis
Authors: Agussuryani Qori , Sudarmin Sudarmin , Sumarni Woro , Cahyono Edy , Ellianawati Ellianawati
Published: March 2022

The low higher order thinking skills (HOTS) of vocational students is shown from the approaches and models used in learning that are not specific, learning activities are limited to methods that have not been able to grow HOTS. One of the approaches offered in science, technology, engineering, and mathematics (STEM). The research objective was to analyze STEM in growing HOTS through literature studies. The data collection method used a STEM systematic review from 2016-2020 based on the indexed findings of Google Scholar and Scopus (Database: Elsevier, Scopus, and Science Direct). Qualitative descriptive data analysis technique was employed on inductive deductive patterns. Based on data analysis, there are findings of 18 Google Scholar indexed articles and 20 Scopus indexed articles according to the inclusion criteria. The results showed that: i) STEM integration patterns in growing HOTS obtained six STEM literacy patterns of 28% on Google Scholar and four STEM integration patterns by 65% in Scopus; ii) The trend of STEM and HOTS research from 2016-2020 has increased the most in 2020 by 56% on Google Scholar and 40% on Scopus. Most of the methods used are research and development (R&D) with data analysis techniques in the form of t-test on Google Scholar data and survey methods with descriptive analysis on Scopus data. The difference in the publication trend on the integration pattern, the number of samples used is greater in the Scopus data. The method used is more dominant in the survey than R&D, but whatever the research design in STEM literacy is, in principle, it can empower HOTS to increase learning activities.
Mathematical connections made during investigative tasks in statistics and probability
Authors: Quilang Liezl Joy Lazaro , Lazaro Lyndon Laborte
Published: March 2022

The Philippines has undergone a fundamental overhaul of its educational system to highlight basic education and overcome its deficiencies. The educational reform prompts prospective teachers to connect the concepts taught to instill a more profound understanding. As such, the researchers explored the mathematical connections made by prospective secondary mathematics teachers while completing investigative tasks. The study employed a concurrent triangulation mixed-methods design. Data were gathered from 39 prospective secondary mathematics teachers enrolled in the state universities' flagship campuses in Northeastern Philippines. Data were gathered using mathematical connections evaluation, think-aloud strategy, and interviews. Frequency counts, percentages, mean percent scores, Pearson product-moment correlation coefficient, and analysis of the interviews' transcriptions were employed in the study. Results showed that the prospective teachers performed best in making instruction-oriented connections but have difficulty in making implications connection. Also, the prospective teachers' ability to successfully make the mathematical connection is directly linked to their knowledge of the concept, the algorithm, and the part-whole relationship. As such, reform efforts should be made to enhance mathematical connections, emphasizing statistical thinking, and reasoning. Moreover, higher education institutions should incorporate connecting as one of the intended learning outcomes for prospective mathematics teachers.
Pre-licensure examination as predictor of licensure examination for teachers result
Authors: Fiscal Rainer R. , Roman Adriel G.
Published: March 2022

Licensure examination for teachers (LET) is the major requirement of teachers in the Philippines before practicing teaching profession. As such, it is imperative to monitor necessary parameters to increase passing percentage of teachers in LET. This study attempted to examine the relationship between performance in pre-LET and LET of 71 elementary education (BEEd) and 127 secondary education (BSEd) graduates in one university in the Philippines. Individual and aggregated data were secured from the college of teacher education dean’s office and Professional regulations commission (PRC). Using the descriptive-correlation method of research, this study presented the null hypothesis that pre-licensure is not a predictor of LET results. Findings showed that there is a notable relationship between the pre-LET and LET examination performances. Using linear regression analysis, ratings attained by the graduates in pre-LET can predict the performance in LET with higher level of confidence. The study confirmed that for general education (GenEd) and professional education components of licensure examination for BEEd, the pre-LET scores of education graduates are significant predictors.
Abstract 109: Neurologists versus Hospitalists: The Effect of Physician Specialty on Stroke Care and Outcomes After Ischemic Stroke and TIA
Authors: Comer Amber R , Comer Adam D , Dethoff Alison , Templeton Evan J , Slaven James J
Published: March 2022

Background:
On July 1, 2015, a 315 bed, level one trauma center changed the delivery of inpatient stroke care. Prior to the transition, stroke patients were admitted and managed primarily by the neurology team. Post transition, stroke patients were admitted under the care of hospitalists, with neurologists utilized as consultants for stroke related care. No previous studies have examined the transition of stroke care within a single hospital. This study compares the effects of physician specialty on stroke care and patient outcome.

Methods:
A retrospective cohort study of 399 patients with ischemic stroke and TIA, treated 14 months pre-and-post a change in stroke care delivery (May 1, 2014 - September 20, 2016), was conducted. ICD-9 and ICD-10 codes were utilized to extract patient information including stroke care and outcome measures, such as prescriptions, diagnostic examination orders, hospital length of stay, mortality, discharge location, and 30-day readmission rates. Chi-square and logistic regression statistical analyses were performed using SAS statistical software.

Results:
287 patients were treated primarily by a neurology team, while 112 patients were treated primarily by a hospitalist team. The average patient age was 61.2 (±13.2) years old. There was no meaningful difference in provision of stroke care between the hospitalist and neurologist teams as measured by 20 stroke care measures including, provision of diagnostic examinations and prescriptions. While patients on the hospitalist teams were found to have statistically shorter length of hospital stay (median (range) = 2 (0-50) days vs. 3 (0 - 46), p<0.01), there were no statistical differences between 30-day readmission rates (17.9% vs. 14.6%, p=0.42), in-hospital mortality (2.7% vs. 4.5%, p=0.57), 30-day all-cause mortality (2.7% vs. 5.9%, p=0.21), or discharge disposition (p=0.45).

Conclusions:
There is no evidence that patients received dissimilar stroke related care or experienced different outcomes regardless of the physician specialty serving as the primary service. However, stroke patients with hospitalists as their primary team had shorter hospital stay. This difference may be due to hospitalists’ expertise in managing patients with multiple co-morbidities, including stroke patients with underlying diabetes, atrial fibrillation, and hypertension. Based on these findings, utilizing neurology as a consult service for stroke related care will not affect provision of stroke care or patient outcomes.
Abstract 121: Anxiety and Depression in Patients With Fibromuscular Dysplasia: A Report From the US Registry for Fibromuscular Dysplasia
Authors: Pawlik Cameron , Kline-Rogers Eva , Olin Jeffrey W , Gornik Heather L , Mace Pamela , Gu Xiaokui , Swan Kirby , Krallman Rachel , Kim Esther S , Wells Bryan J , Weinberg Ido , Sharma Aditya M , Gray Bruce , Froehlich James B
Published: March 2022

Introduction/Background:
Fibromuscular dysplasia (FMD) is a non-inflammatory, non-atherosclerotic arterial disease that may result in arterial stenosis, dissection, aneurysm, and tortuosity. Anxiety (A) and depression (D) are prevalent in patients with rare and uncommon diseases compared to the general population; however, there are limited data on A and D in the FMD population. This study describes characteristics of FMD patients with and without A and/or D (A/D).

Methods:
Patients enrolled in the US Registry for FMD between 2009-2017 and had A/D information were analyzed (n=985). Diagnosis of A/D was ascertained from patient charts or self-reported via medical history questionnaires at time of registry enrollment. Demographics, family history, past medical history, presenting symptoms, and affected vascular beds were compared between patients with and without A/D.

Results:
A total of 351 (35.6%) had A/D. Of patients with A/D, 126 (35.9%) had both. Patients with A/D were more likely to have a family history of aneurysm (33.6% v. 23.7%, p=0.001) and stroke (53.6% v. 46.1%, p=0.03), and have a medical history of hemispheric TIA (15.5% v. 10.9%, p=0.04), subarachnoid hemorrhage (4.4% v. 1.8%, p=0.015) and smoking (43% v. 28%, p<0.001). Patients with A/D were more likely to present at the time of diagnosis with headache (68.6% v. 53.8%, p<0.001), pulsatile tinnitus (42.2% v. 34%, p=0.014), dizziness (45.3% v. 29.2%, p<0.001), neck pain (40% v. 24.9%, p<0.001) and carotid/vertebral arterial dissection (21.6% v. 14.7%, p=0.007). Patients with A/D were less likely to have renal artery FMD (58.4% v. 68.9%, p=0.002). No differences in the time between symptom onset and FMD diagnosis (2.7±6.2 v. 3.1±6.9 years, p=0.89) or number of vascular beds involved (1.9±1.1 v. 1.9±1.1, p=0.77) were seen between groups.

Conclusions:
More than 1/3 of patients in the FMD registry had A, D, or both, and these patients showed multiple differences compared to patients without A/D. More study is required to understand this relationship. Given the high prevalence of A/D in this population, FMD patients should be screened for the presence of A/D and offered appropriate treatment.
Abstract 136: Blood Pressure Control According to Race and Gender in a University Cardiology Clinic
Authors: Ahmad Sajjad , Hujier Fares , Omar Bassam A , Awan G. Mustafa , Malozzi Christopher
Published: March 2022

Background:
Racial and gender differences influence control of coronary disease risk factors, and have often been related to socioeconomic issues.

Methods:
Encounters from a university-based primary cardiology clinic with broad referral base were analyzed for BP by race and gender in patients on antihypertensive medications.

Results:
A total of 200 encounters were examined: 53% (105) females; systolic BP (SBP) 134 ± 20 mmHg compared with 47% (95%) males; SBP 130 ± 18 mmHg (NS). There were 50% (100) African American; SBP 134 ± 20 mmHg compared with 50% (100) White patients; SBP 130 ± 18 mmHg (NS). Comparing each subgroup to the remainder of the patients revealed African American females (AAF) with SBP of 137 ± 21 mmHg (P < 0.01), White females with SBP 129 ± 19 mmHg (NS), African American males with SBP 128 ± 18 mmHg (NS), White males SBP 131 ± 18 mmHg (NS). Diastolic BP was 83 ± 13 mmHg in AAF compared with 78 ± 11 mmHg in the remaining groups (P < 0.01). Age, heart rate, LDL levels and weights in AAF were 59 ± 13 years, 70 ± 10 BPM, 91 ± 44 mg/dL and 214 ± 77 lbs compared with 61 ± 13 years, 70 ± 12 BPM, 88 ± 38 mg/dL and 209 ± 68 lbs respectively in the remaining patients (NS).

Conclusion:
Highest documented BP was observed in African American females with treated hypertension. Lack of compliance with medications is unlikely as these patients had insurance and their LDL levels were adequately controlled with medications. Slightly higher body weight in AAF, though not statistically significant, may have contributed to a higher BP. White-coat-hypertension is another potential explanation, which has been previously reported to be prevalent in African American females. Further studies with ambulatory BP monitoring may help better explain this observation. AAF remain at very risk for cardiovascular disease, and would benefit from efforts to improve detection and control of hypertension, in addition to other cardiac risk factors.
Abstract 139: Examining the Effect of Post-Hospital Syndrome on Outcomes in Patients Discharged After an Acute Coronary Syndrome
Authors: Gajar Anicka , Krallman Rachel , Montgomery Daniel , Morgan Spencer , Kline-Rogers Eva , Eagle Kim A , Bumpus Sherry M
Published: March 2022

Background:
Hospital readmissions are increasingly observed and reported as quality indicators. The literature is critical of studies that use
all cause
readmission definitions, suggesting that not every readmission is related to the index admission diagnosis. However, hospitals are not a therapeutic environment. Patients are often kept on ”nothing by mouth” (NPO) status, subjected to testing at irregular hours, placed on bed rest, and discharged on new medications. Thus, patients may be more vulnerable to adverse outcomes at discharge; some have characterized this phenomenon as “post-hospital syndrome.” This study sought to compare these inpatient stressors (NPO status, after-hours testing, new medications, and bed rest) to patient outcomes (ED visits, readmissions).

Methods:
A retrospective chart review of 100 randomly selected ACS patients referred to a cardiac transitional care program (BRIDGE) between 2014-2015 was conducted. Associations between hours NPO, number of new medications, number of tests at irregular hours (11pm-5am), prescribed bed rest and outcomes at 30 and 180 days were analyzed.

Results:
Of 100 patients, 72% were male with a mean age of 65.87 ± 12.33 and a mean Charlson comorbidity score of 5.42 ± 2.58. Bed rest was prescribed for 69% of patients. The average patient was prescribed 4.43 new medications at discharge, underwent 4.37 tests at irregular hours, and spent 11.40 hours NPO. Median length of stay was 3 days (range: 0-18 days). Number of tests at irregular hours was positively correlated with readmission at 30 days (r=0.272, p=0.006), and 180 day ED visits (r=0.282, p=0.004) and readmissions (r=0.363, p<0.001). No other significant correlations were observed between inpatient stressors and outcomes.

Conclusions:
NPO status and tests at irregular hours were correlated with negative short and longer-term outcomes. Efforts should be made to limit these inpatient stressors or to stabilize patients prior to discharge. Future research on post hospital syndrome is warranted to better understand potential longer-term relationships and to better plan for care transitions.