bluuebunny/crossref_metadata_2025 huggingface dataset:
Psychometric Assessment of the Malay Version of the 14-Item Resilience Scale (RS-14) in Women With Breast Cancer
Authors: Hashim Che Gon , Taib Nur Aishah , Yoon Hwan-Jin , Larkin David , Yip Desmond , Lopez Violeta
Published: February 2021

Background and purpose

There are a lack of documentation on psychometric assessments on the Malay version of 14-item Resilience scale (RS-14) in Malaysia. This study was to empirically assess its reliability and validity.

Method

A prospective test–retest design was employed on Malaysian women with early breast cancer (N = 105). Data were analyzed using SPSS version 24.

Results

The results showed overall Cronbach alpha values were .92 and .93 for test–retest, respectively. Intraclass correlation coefficient (ICC) values ranged between .62 and .75. This study accepted three factors and two factors for test–retest, respectively. Individual factors showed Cronbach alpha average ranged from .71 to .91.

Conclusion

The Malay version RS-14 tool was found to be statistically valid, reliable, and reproducible. It was able to measure resilience level in those women under study.
Total Kalça Protezi Uygulanan Bireylerin Taburculuk Sonrası Yaşadıkları Komplikasyonların Belirlenmesi
Authors: BALKAN Ali , SEKİ Züleyha
Published: February 2021

Bu çalışma Total Kalça Protezi (TKP) uygulanan bireylerin taburculuk sonrası ilk 15 günde gelişen komplikasyonları saptamak amacıyla tanımlayıcı olarak gerçekleştirilmiştir. Tanımlayıcı nitelikte yapılan araştırmaya Ege Bölgesinde bir üniversite hastanesi ve özel hastanenin ortopedi ve travmatoloji ve genel cerrahi kliniklerinde TKP ameliyatı uygulanan 100 birey dahil edilmiştir. Araştırmanın verileri literatür bilgileri doğrultusunda geliştirilen veri toplama formu ve komplikasyon değerlendirme formu kullanılarak yapılmıştır. Bu çalışmada TKP uygulanan bireylerin taburculuk sonrası ilk 15 günde gelişen komplikasyonlarına bakıldığında; en fazla %69 ile halsizlik gelişirken, %1 ile en az enfeksiyon gelişimi saptanmıştır. Rutin olarak verilen hemşirelik eğitiminin yetersiz olduğu istatistiksel olarak anlamlı bulunmuştur (P < 0,05). Bedensel Kütle İndeksi (BKİ) kilolu ve obez olan bireylerin daha fazla TKP ameliyatı geçirdiği ve BKİ’si yüksek olan bireylerde komplikasyon gelişimi arasında istatistiksel olarak anlamlı bir ilişki saptanmıştır (P < 0,05). TKP uygulanan bireylerin taburculuk sonrası komplikasyon gelişimi açısından riskli olan ameliyat sonrası ilk 15 günü içeren dönemdeki değerlendirmeler ve komplikasyonların erken dönemde belirlenmesi önem arz etmektedir. Bu dönemin hasta açısından sorunsuz geçirilebilmesi için taburculuk eğitimlerinin planlanması ve hastaların takibinin yapılması önerilmiştir.
Scientific journalism in the times of pandemic and conspiracy theories
Authors: Trzeciak Marta Alicja
Published: February 2021

On March 11, 2020, the World Health Organization announced the state of the coronavirus outbreak as a pandemic. This has contributed to the deepening of feelings of fear, anger, frustration and dissatis-faction in many people, as well as the emergence of numerous conspiracy theories related to the new coronavirus. These concepts are socially dangerous because, without bringing any positive reactions, they deepen the feeling of fear, panic or even hysteria. Thus, they hinder rational thinking, taking care of one’s own mental health and acting reasonably. This article discusses the most frequently repeated conspiracy theories in public discourse: corona-virus as a Chinese biological weapon, SARS-CoV-2 as an American biological weapon, the coronavirus created by the USA for profit, SARS-CoV-2 created or developed by Jews, the virus as an element of spy action, the pandemic as a population control program, and 5G as the cause of the pandemic.
Doświadczenie politycznej poprawności a grzeczność językowa
Authors: Garbicz-Stodolna Dorota
Published: February 2021

The aim of the article is to define the status of political correctness in the Polish language and its re-lationship with linguistic politeness. An important element is to describe the various approaches and attempts to define political correctness and to reflect on the ideologization of the studied phenomenon. The first step is to develop a theoretical basis, discussing the issue of linguistic politeness and political correctness. In the next part, both phenomena are confronted and their relationships are discussed via the example of the lexeme Murzyn (Black). The analysis of the problem showed the ideological entangle-ment of political correctness and a negative evaluation of this phenomenon, despite the assumptions convergent with linguistic politeness, which does not raise objections from language users.
Discursive processing of cultural topics in broadcast content of programs on Polish Radio One — a confrontative review
Authors: Wilk Jakub
Published: February 2021

The article describes the analysis of ways in which cultural topics are presented in radio broadcasts. Two episodes of the programme Cztery pory roku (broadcast by Polish Radio One) were analysed. The aim was to determine if the discourse generated by the radio station contains the cultural background (related to Fat Thursday) that is used in communication with the audience, and if so — what are the transformation areas and general principles of it.The examined material was selected in a non-probabilistic way, considering the proportional weight of the compared elements. The analysed content consists of two episodes (dated 23rd February 2017 and 20th February 2020) — this made the confrontative comparison method available. The sample was analysed both quantitatively and qualitatively. The quantitative research part contains calculations of air time management for both episodes and summary of proportions between equivalent programme contents in different years. The qualitative research part reports the composition of broadcast content and its macrostructure. Here are shown the means used by the station to shape the discourse to process the cultural content and also ways of using the cultural background in the generated media discourse.The results prove that there is an area of consistency in the broadcaster’s discourse — unaffected by a three-year distance between the analysed episodes. The structure of the programme mostly does not change as well as its substantive shape. Among the noticed changes are (in the 2020 episode): a widened time period containing culture-related topics, a limited number of social-sensitive topics, a growth in the number of mentioned global topics but without their substantive extension.
Llaga de amor viva. El “Cántico” espiritual de Blas de Otero y sus ecos sanjuanistas
Authors: Krupa Marlena
Published: February 2021

En su juventud Blas de Otero fue un lector muy atento de la poesía de San Juan de la Cruz. Las marcas de esta lectura son claramente visibles en su primer libro de poemas, que tiene el mismo título que uno de los tres poemas místicos más importantes escritos por el místico carmelita: Cántico Espiritual. El objetivo de este artículo es investigar el lenguaje poético del Cántico Espiritual de Blas de Otero y describir la forma en que fue influido por la poética de San Juan de la Cruz.
Lung Cancer-Related Pneumopericardium
Authors: Oliveira Santos Pedro , Caldeira João Pedro
Published: February 2021

N/a.
How Effective Public Managers Transform Separation of Powers into “Inseparable Powers” in United States Foster Care Administration Networks
Authors: Padot Rebecca
Published: February 2021

Results from a four state foster care administration field research study in the United States with over 55 key player interviews produced data on what particular networking practices public managers perform that contributes to foster care administration effectiveness.  One of these practices was the concept of inseparable powers, whereby the traditional checks and balances roles of the judicial, executive, and legislative branches are slightly altered in eras of state-level foster care administration effectiveness.  During a period of inseparable powers, effective public managers work across the state branch boundaries in the United States with partners from other branches to produce better foster care outcomes.
Retreatment of mesial roots of mandibular molars filled with resin- based and bioceramic sealers
Authors: Salim Marina de Almeida , Ormiga Fabiola , Lopes Ricardo Tadeu , Gusman Heloisa
Published: February 2021

Aim: The aim of this study was to evaluate, by micro-computed tomography (micro-CT) analysis, the remaining filling material during endodontic retreatment performed with Protaper retreatment without solvent. Methods: Forty mandibular molars were divided into two groups (n = 20) according to the sealer used in the obturation: the bioceramic TotalFill BC (TF) or the resin-based AH Plus (AHP). The specimens were scanned before instrumentation, after obturation and after filling removal. Only the mesial roots were analysed. The filling volumes and the remaining filling material were calculated in the entire root canal and in the cervical, middle and apical thirds. Results: The volume of obturation and the volume of remaining filling material in the entire root canal and in the cervical, middle and apical thirds of the canal between the groups were not statistically different (independent t-test, p > 0.05). In the AHP group, there was a higher percentage of remaining filling material in the middle third than in the cervical third (p < 0.05). Conclusion: The filling material could not be entirely removed from any specimen.
Life Experience of Pregnant Woman with Gestational Diabetes Mellitus in Maternal Role Attainment in Special Region of Yogyakarta
Authors: Wulaningsih Indah , Hapsari Elsi Dwi , Pangastuti Heny Suseani , Priharjo Robert
Published: February 2021

Introduction: Gestational Diabetes Mellitus (GDM) is any abnormal carbohydrate intolerance that begins or is ﬁrst recognized during pregnancy. The presence of GDM has important implications for both the baby and the mother. Objective:  This study explored life experience of pregnant woman with GDM in maternal role attainment. Methods: This was a phenomenological approach qualitative research. Participants were 12 mothers who gave birth to a maximum of 1 year with a history of GDM selected by purposive sampling technique with sampling criteria. Data analysis used the Colaizzi method (2011). Results: There were eight categories, e.g. the experience of the mother in GDM diagnosis; the influence GDM of the pregnancy; mother's experience in trying hard to   keep her pregnancy; a variation of life experience of mothers during pregnancy, childbirth, and post-delivery; the perception of mother of her role being a mother, the factors that support the development and achievement of the maternal role attainment; the mother's experience in integrating the identity of her role as mother; gap and the desire of the mother with GDM in receiving health services. Life experience of GDM mothers in achieving  maternal role attainment has a diversity. Discussion: Pregnant mothers with GDM experience various maternal role attainments. They cannot attain the role optimally.
Research Utilization and Evidence-Based Practice in Education and Nursing Practice
Authors: Dewi Yulis Setiya , Mani Smriti Kana
Published: February 2021

Editorial: Research Utilization and Evidence-Based Practice in Education and Nursing Practice
Acquisition Cost of Land and Building Rights Based on Buying and Selling
Authors: Adhi Singgih Permana
Published: February 2021

The collection of regional taxes and levies must be based on Law Number 28 of 2009 concerning Regional Taxes and Regional Levies, and for the Banyumas Regency area, it has been regulated in Regional Regulation Number 1 of 2011 concerning Regional Taxes in conjunction with Regional Regulation Number 22 of 2016 concerning Amendments to the Second Regulation Region Number 1 the Year 2011 concerning Regional Taxes. One type of tax that is under the authority of the regions is the Fees for Acquisition of Rights on Land and Buildings, hereinafter referred to as BPHTB. The approach method used in thisresearch is the normative juridical approach method. The data used are secondary data and primary data as a complement to secondary data. The results and discussion are the application of BPHTB based on the  sale and purchase of the implementation including the process of filling in the SSPD BPHTB, determining tax objects, tax taxes, calculating taxes, research or validation, and payment. BPHTB is based on the sale and purchase of applications based on the PDRD Law and Regional Tax Regulations, the basis for calculating the BPHTB is the transaction price, therefore based on the Regent Regulation, the RegionalFinance Agency carries out a research procedure (validation) of BPHTB based on buying and selling with the truth of the transaction price value used to calculate BPHTB. PPAT which regulates the deed of transfer of rights, without ta  supervision has been paid and validated giving legal consequences for PPAT in the form of sanctions in the form of fines for each award. Law enforcement of sanctions on administrative fines against PPAT and the procedures for its implementation are not regulated and have not been further regulated in the PDRD Law, Regional Tax Regional Regulations, or in implementing regulations.Keywords: Regional Taxes; Fees for Acquisition of Rights on Land and / or Buildings; Legal Consequencesof Land Deed Making Officials.
Authentication of Deed of Minutes of General Meeting of Shareholders Implemented With The Concept of Cyber Notary Reviewed From Article 16 Paragraph (1) Letter M of Law No. 2 of 2014 On Notary Department
Authors: Amrullah Reza
Published: February 2021

Cyber Notary is the use or utilization of information technology such as computers, computer networks, and/or other electronic media, such as teleconferences or video conferences in carrying out the tasks of the authority of a Notary Public. This study analyzes the authentication of electronic documents in the form of the minutes of the General Meeting of Shareholders in the Cyber Notary concept and the proof of the minutes of the General Meeting of Shareholders held with the concept of Cyber Notary. The research method used in this study is normative juridical. The source of legal material in this research is secondary legal material. This Legal Material Analysis Method is Normative Qualitative. Based on the results of the study found that Authentication of electronic documents in the form of the minutes of the General Meeting of Shareholders in the concept of Cyber Notary can be done by means of a Notary does not need to be present during the General Meeting of Shareholders of the Cyber Notary takes place. If the Notary is present directly at the meeting then it is actually dangerous for the Notary, because in the Cyber Notary RUPS there are meeting participants who attend using teleconferences or video conferences that do not allow the Notary to get to know all meeting participants who were present at the meeting. Making Deed of Minutes of the meeting is sufficient to be made by a Notary based on the Minutes of Meeting under the hand of the authorized shareholders to the Board of Directors to be drawn up by a Notary. Keywords: Strength of Proof; GMS Deed; Cyber Notary.
Application of Prudential Principles in Registration of Granting Mortgage Right (APHT)
Authors: Kusumaningrum Hesti
Published: February 2021

The precautionary principle serves as a guideline for PPAT in carrying out the APHT registration process. In-Law No.4 of 1996 concerning Underwriting Rights, PPAT Position, and Civil Regulations No.1 Year 2006 implies the precautionary principle regarding the provision that the PPAT is personally responsible for the duties and authorities in the process of making the deed. PPAT must apply accuracy in registering APHT to the Land Office. Registration becomes an important moment for the birth of Underwriting Right, the fulfillment of the principle of publicity, the position of the preferred creditor as the holder of the Underwriting Right. The data used in this study are secondary data with primary data as secondary data supplementary data. The approach method used in this study is the normative juridical approach. The results of the study obtained concluded that 2 (two) terms of the application of the precautionary principle of the form and content of APHT made by PPAT in accordance with applicable regulations, however, APHT registration occurred later than the 7 (seven) working day deadline. Not applying the precautionary principle can lead to legal consequences for the PPAT, APHT. and preferred creditors, from the aspects of civil, criminal, and administrative law. Preventive and repressive legal protection for all parties concerned in the series of APHT registration processes. Suggestions for PPAT need to apply the precautionary principle to minimize late APHT registration, the Land Office needs to apply administrative sanctions. Keywords: prudential principles; APHT registration; legal consequences
The Role of The National Land Agency in Monitoring The Issuing Land Deed by The Temporary Land Deed Officer in Indramayu Regency
Authors: Astuti Sabrina Widya
Published: February 2021

This study aims to analyze how the role of the National Land Agency in terms of supervision of the making of a land deed by the Acting Land Actor in the District of Indramayu. based on research that has been carried out the role of supervision carried out by the National Land Agency in Indramayu Regency contained in the regulation of the Minister of Agrarian Affairs and Spatial Planning No. 2 of 2018 concerning Supervision and Development of Land Deed Making Officials. Research shows that supervision of the Temporary Land Deed Making Officials in Indramayu Regency has not been carried out by the National Land Agency. Supervision based on Permen ATR Number 2 of 2018 namely preventive and repressive supervision. Preventive supervision is to supervise the implementation of the PPAT position while repressive supervision is carried out by enforcing the rule of law in accordance with statutory provisions in the PPAT field. Keywords: National Land Agency, supervision, PPAT
Local Government Policy in The Procurement of Rental Official Vehicle (ROV) in Keerom District, Papua
Authors: Bawono Icuk Rangga , Pradana Adhitia
Published: February 2021

The implementation of regional government requires supporting facilities and infrastructure for the smooth implementation. One of them is adequate transportation facilities. Therefore, the local government provides official vehicles for commitment and responsibility in giving attention and concern to duties of the state civil apparatus implementation. This study aims to formulate urgency of leasing operational service vehicles in the Keerom District Government. This study uses normative legal research as research method. The legal material obtained will describe and relate in such a way that it is presented in a more systematic writing to answer problems that have been formulated. Result shows the procurement of official vehicles was chosen through the rental process to minimize expenditure in the context of budget economy, effectiveness, and efficiency. Rental official vehicles in the Keerom Regency Government function as a support for regional government in achieving targets as its responsibility to provide welfare for community. Keywords: local government; operational service vehicles; rental
The Role of Alveolar Edema in COVID-19
Authors: Yuan Shu , Jiang Si-Cong , Li Zi-Lin
Published: February 2021

The coronavirus disease 2019 (COVID-19) has spread over the world for more than one year. COVID-19 often develops life-threatening hypoxemia. Endothelial injury caused by the viral infection leads to intravascular coagulation and ventilation-perfusion mismatch. However, besides above pathogenic mechanisms, the role of alveolar edema in the disease progression has not been discussed comprehensively. Since the exudation of pulmonary edema fluid was extremely serious in COVID-19 patients, we bring out a hypothesis that severity of alveolar edema may determine the size of poorly-ventilated area and the blood oxygen content. Treatments to pulmonary edema (alcohol-oxygen vapor therapy and fluid management) may be great helpful for reducing occurrence of severe cases. Given that late mechanical ventilation may cause mucus (edema fluid) to be blown to the deep of the small airways, oxygen therapy should be given at the early stages. The optimal time and SpO2 threshold for oxygen therapy are also discussed.
Shark Conservation – Analysis and Synthesis
Authors: Porcher Ila France , Darvell Brian W , Ziegler Iris
Published: February 2021

A detailed analysis of fishing records has shown that the shark species accessible to global fisheries have been systematically depleted for decades. They were already fished to about 10 percent of their former levels by 2003. Now one species after another is being listed on the IUCN Red List of Threatened Species as their numbers drop towards extinction. Shark depletion has not been well documented and a large proportion of shark mortality has been bycatch, the target species being teleost fish. But with the rise in value of shark fins due to the shark fin trade, at the same time as teleost fish stocks have become severely overfished, sharks, along with tuna, have become the most valuable catches. Fishing on the high seas is scarcely profitable, and so is heavily supported by subsidies. But the shark fin trade, in which organized crime is heavily involved, is driven by enormous profits and provides a powerful demand for the fins of all sharks. Thus it is now being supplied by fisheries around the world. There is no interest in sustainability in consumer countries, and neither the will nor the resources to manage the trade exist. Although some shark fisheries might have been managed sustainably in some regions for certain species for meat, such fisheries are increasingly dependent on the shark fin trade.. The rising global demand for shark fins, coupled with the increasing depletion of the animals supplying that demand, makes commercial fishing for sharks unsustainable. Given their high ecological value across the aquatic ecosystems they inhabit, it is important that they receive more effective measures of protection going far beyond the currently existing ones. In particular, protection of all sharks, manta rays, devil rays and rhino rays through an Appendix I CITES listing should be effected immediately due to the scale of the global take of the shark fin trade and the state of shark depletion amply documented in the literature.
Oligodendroglial Energy Metabolism and (re) Myelination
Authors: Tepavcevic Vanja
Published: February 2021

Central nervous system (CNS) myelin has a crucial role in accelerating the propagation of action potentials and providing trophic support to the axons. Defective myelination and lack of myelin regeneration following demyelination can both lead to axonal pathology and neurodegeneration. Energy deficit has been evoked as an important contributor to various CNS disorders, including multiple sclerosis (MS). This suggests that dysregulation of energy homeostasis in oligodendroglia may be an important contributor to myelin dysfunction and lack of repair observed in the disease. This article will focus on energy metabolism pathways in oligodendroglial cells and highlight differences dependent on the maturation stage of the cell. In addition, it will emphasize that the use of alternative energy sources by oligodendroglia may be required to save glucose for functions that cannot be fulfilled by other metabolites, thus ensuring sufficient energy input for both myelin synthesis and trophic support to the axons. Finally, it will point out that neuropathological findings in a subtype of MS lesions likely reflect defective oligodendroglial energy homeostasis in the disease.
Microring Distributed Sensors Using Electron Cloud Generated by Four-point Probe Sagnac Interferometer
Authors: Garhwal Anita , Arumona Arumona Edward , Ray Kanad , Youplao Phichai , Singh Ghanshyam , Yupapin Preecha
Published: February 2021

A micro Sagnac interferometer integration is proposed for electron cloud distributed sensors. The Sagnac interferometer consists of four microring probes integrated into a Sagnac loop. Each of the microring probes is embedded with the silver bars to form the plasmonic wave oscillation. At the center microrings, electrons are trapped and oscillated by the whispering gallery modes (WGMs), where the plasmonic antennas are established and applied for wireless fidelity (WiFi) and light fidelity (LiFi) transmissions for distributed sensors. The antenna gains are 2.59dB, 0.93dB, 1.75dB, and 1.16dB respectively for the four antennas formed at the center microrings. The polarized light of 1.50µm wavelength is fed into the interferometer input, which is polarized randomly into upstream and downstream directions. The polarization components can be obtained by the space-time modulation control. By controlling the electron cloud spin orientation, the space-time projection can be applied, and the ultra-high measurement resolution can be obtained in terms of fast switching time (change in phase). In manipulation, the applied stimuli are substituted by the change in input source power. The light input power variation causes a change in electron cloud density. Similarly, when the electron cloud is excited by the microscopic medium, which can be employed as the microscopic sensors. The WGM sensors have sensitivities of 1.35µm-2, 0.90µm-2, 0.97µm-2 and, 0.81µm-2, respectively. The WGMs behave as a four-point probe for the electron cloud distributed sensors, where the electron cloud sensitivities of 2.31 prads-1mm3 (electrons)-1, 2.27prads-1mm3 (electrons)-1, 2.22 prads-1mm3(electrons)-1, 2.38prads-1mm3(electrons)-1 are respectively obtained.
Coordinated Adaptive Directional Overcurrent Protection System for AC Microgrids
Authors: Hussain Noor , Nasir Mashood , Khayat Yousef , Vasquez Juan C. , Guerrero Josep
Published: February 2021

In this research work, an adaptive scheme for the coordinated protection of AC Microgrids using directional overcurrent (DOCR) relays is presented. Protection of AC MGs is a complex and challenging issue due to the dynamic nature of the network including, a) its capability to reconfigure the modes of operation ranging from grid-connected to the islanded mode, c) bidirectional-power flow capability, and c) integration of intermittent renewable energy resources with real-time variations in the resource availability. Consequently, the fault current contributions may largely vary depending upon the incident conditions on the network. Conventional protection schemes, generally designed for radial networks, and unidirectional power flow from the source end to the load may either mal-operate or exhibit very poor performance, if not adapted according to the dynamic conditions of the network. To address this issue, a communication-based adaptive protection scheme capable to adapt its settings according to the generation resource availability and network configuration is presented in this work. The proposed scheme consists of an intelligent central protection unit (ICPU) capable to update the settings and communicate it to the individual relays based on the pre-calculated offline settings. The directional overcurrent relays employed in the scheme use two-stage settings, i.e. definite time and inverse definite minimum time characteristics for the effective coordination among the downstream and upstream relays. An adaptive algorithm for ICPU operation is presented and a case study is implemented for a modified IEEE 9-bus system using DigSilent Power factory. The results for various scenarios including, a) grid-connected mode of operation, b) islanded mode of operation, and c) variable distributed generation mode are obtained and compared to the static scheme, which validates the effectiveness of the proposed scheme.
Characterizing the Performance of a Compact BTEX GC-PID for Near-Real Time Analysis and Field Deployment
Authors: Frausto-Vicencio Isis , Moreno Alondra , Goldsmith Hugh , Hsu Ying-Kuang , Hopkins Francesca M.
Published: February 2021

In this study, we test the performance of a compact gas chromatograph with photoionization detector (GC-PID) and optimize the configuration to detect ambient (sub-ppb) levels of benzene, toluene, ethylbenzene, and xylene isomers (BTEX). The GC-PID system was designed to serve as a relatively inexpensive (~$10k) and field-deployable air toxic screening tool alternative to conventional benchtop GCs. The instrument uses ambient air as a carrier gas, and consists of a Tenax-GR trap preconcentrator, a gas sample valve, two capillary columns, and a photoionization detector (PID) with a small footprint and low power requirement. The performance of the GC-PID has been evaluated in terms of system linearity and sensitivity in field conditions. The BTEX-GC system demonstrated the capacity to detect BTEX at levels as high as 500 ppb with a linear calibration range of 0-100 ppb. A detection limit lower than 1 ppb was found for all BTEX compounds with a sampling volume of 1 L. No significant drift in the instrument was observed. A time-varying calibration technique was established that requires minimal equipment for field operations and optimizes the sampling procedure for field measurements. With an analysis time of less than 15 minutes, the compact GC-PID is ideal for field deployment of background and polluted atmospheres for near-real time measurements of BTEX. The results highlight the application of the compact and portable GC-PID for community monitoring and screening of air toxics.
Androgen Receptor Binding Prediction with Random Forest, Deep Neural Networks, and Graph Convolutional Neural Networks
Authors: García-Sosa Alfonso T.
Published: February 2021

Substances that can modify the androgen receptor pathway in humans and animals are entering the environment and food chain with the proven ability to disrupt hormonal systems and leading to toxicity and adverse effects on reproduction, brain development, and prostate cancer, among others. State-of-the-art databases with experimental data of human, chimp, and rat effects by chemicals have been used to build machine learning classifiers and regressors and evaluate these on independent sets. Different featurizations, algorithms, and protein structures lead to different results, with deep neural networks on user-defined physicochemically-relevant features developed for this work outperform graph convolutional, random forest, and large featurizations. The results can help provide clues on risk of substances and better experimental design for toxicity assays. Source code and data are available at https://github.com/AlfonsoTGarcia-Sosa/ML
Accuracy analysis and improvement for the cell-centered scheme with the quasi-one-dimensional reconstriction
Authors: Bakhvalov Pavel Alexeevisch
Published: February 2021

We study the cell-centered finite-volume scheme with the quasi-one-dimensional reconstruction. For the model transport equation with a constant velocity, we prove that on translationally-invariant (TI) triangular meshes it possesses the second order of the truncation error and, if the solution is steady, the third order of the solution error. We offer the modification possessing the third order of the solution error on TI-meshes for unsteady solutions also and verify its accuracy on unstructured meshes.
Method of designing technology for future teacher intellectual work culture formation
Authors: Mukhametshin Alexandr Albertovich , Nasibullov Ramis Rafagatovich , Adilova Valentina Khamitovna
Published: February 2021

Relevance of the problem under study is due to the need for monitoring diagnostics of the intellectual work culture formation of future teacher and the lack of development of specific ways, approaches and conditions of technology as a way of its qualitative design. The purpose of the article is to develop a method for designing the technology for forming the future teacher's intellectual work culture in line with the anthropological paradigm and testing it. Research methods: the leading method of researching this problem is modeling a method of designing technology, which allows analyzing the methodological, theoretical, technological and practical ways, approaches and conditions for future teacher intellectual work culture formation. Results of the research: the article presents a method of designing technology for future teacher intellectual work culture formation, consisting of differentiation of ways, psychological and pedagogical conditions, and effective approaches established through monitoring diagnostics and determining the goal of its concept in line with the anthropological paradigm. Practical significance: The method of designing technology for future teacher intellectual work culture formation is aimed at transforming specific types of activity of the students on the basis of quality determination, the efficiency and effectiveness of the ways policies and conditions by means of monitoring diagnostics.
PELAKSANAAN HARMONISASI RANCANGAN UNDANG-UNDANG PERLINDUNGAN DATA PRIBADI (RUU PDP)
Authors: Widyantari Padma , Sulistiyono Adi
Published: February 2021

Abstract
Establishment of legislation is the process of making legislation basically starting from planning, preparation, techniques of preparation, formulation, discussion, endorsement, enactment, and dissemination. Among the series of processes above, there is a process that is not explicitly mentioned but has a very important role, namely the harmonization process. Harmonization is one of a series of processes for the formation of legislation which is an effort to harmonize a statutory regulation with other laws and regulations, both higher, equal and lower, and other matters outside of legislation. laws, so that they are arranged systematically, not conflicting or overlapping. The problem in this study is how to harmonize the Personal Data Protection Bill. The method of this study uses a descriptive normative legal research approach with a statute approach . The primary legal sources are laws, books, journals, while the secondary legal sources are the results of interviews with related parties. The results of this study are expected to allow readers to know how to implement harmonization of legislation in general, and the implementation of harmonization of the Personal Data Protection Bill in particular.
Keywords: Harmonization; Legislation; Personal Data Protection Bill.

Abstrak
Pembentukan peraturan perundang-undangan adalah proses pembuatan peraturan perundangundangan pada  dasarnya dimulai dari perencanaan,persiapan,  teknik penyusunan,perumusan,pembahasan, pengesahan,
pengundangan, dan penyebarluasan. Di antara rangkaian proses di atas ada proses yang tidak disebutkan secara tegas tetapi mempunyai peran yang sangat penting, yaitu proses harmonisasi.Harmonisasi merupakan
salah satu dari rangkaian proses pembentukan peraturan perundang-undangan yang merupakan upaya untuk menyelaraskan suatu peraturan perundangundangan dengan peraturan perundang-undangan lain,  baik  yang  lebih tinggi,  sederajat, maupun yang  lebih rendah,  dan  hal-hal lain di  luar  peraturan perundang-undangan, sehingga tersusun secara  sistematis, tidak  saling  bertentangan atau tumpang tindih (overlaping). Permasalahan dalam kajian ini adalah bagaimana pelaksanaan harmonisasi Rancangan Undang-Undang Perlindungan  Data Pribadi Metode kajian ini menggunakan metode pendekatan penelitian hukum normatif deskriptif
dengan pendekatan perundang-undangan (statute approac). Adapun sumber hukum primernya adalah undang-undang, buku, jurnal, sedangkan sumber hukum sekundernya adalah hasil wawancara pihak terkait. Hasil kajian ini diharapkan agar pembaca mengetahui bagaimana pelaksanaan harmonisasi peraturan perundang-undangan pada umumnya, dan pelaksanaan harmonisasi Rancangan UndangUndang Perlindungan Data Pribadi pada khususnya.
Kata Kunci: Harmonisasi; Peraturan Perundang-Undangan; RUU Perlindungan Data Pribadi.
Projected All-Cause Deaths Attributable to COVID-19–Related Unemployment in the United States
Authors: Matthay Ellicott C. , Duchowny Kate A. , Riley Alicia R. , Galea Sandro
Published: February 2021

Objectives. To project the range of excess deaths potentially associated with COVID-19–related unemployment in the United States and quantify inequities in these estimates by age, race/ethnicity, gender, and education.

Methods. We used previously published meta-analyzed hazard ratios (HRs) for the unemployment–mortality association, unemployment data from the Bureau of Labor Statistics, and mortality data from the National Center for Health Statistics to estimate 1-year age-standardized deaths attributable to COVID-19–related unemployment for US workers aged 25 to 64 years. To accommodate uncertainty, we tested ranges of unemployment and HR scenarios.

Results. Our best estimate is that there will be 30 231 excess deaths attributable to COVID-19–related unemployment between April 2020 and March 2021. Across scenarios, attributable deaths ranged from 8315 to 201 968. Attributable deaths were disproportionately high among Blacks, men, and those with low education.

Conclusions. Deaths attributable to COVID-19–related unemployment will add to those directly associated with the virus and will disproportionately burden groups already experiencing incommensurate COVID-19 mortality.

Public Health Implications. Supportive economic policies and interventions addressing long-standing harmful social structures are essential to mitigate the unequal health harms of COVID-19.
Wage-Setting Policies, Employment, and Food Insecurity: A Multilevel Analysis of 492 078 People in 139 Countries
Authors: Reeves Aaron , Loopstra Rachel , Tarasuk Valerie
Published: February 2021

Objectives. To examine the association between wage-setting policy and food insecurity.

Methods. We estimated multilevel regression models, using data from the Gallup World Poll (2014–2017) and UCLA’s World Policy Analysis Center, to examine the association between wage setting policy and food insecurity across 139 countries (n = 492 078).

Results. Compared with countries with little or no minimum wage, the probability of being food insecure was 0.10 lower (95% confidence interval = 0.02, 0.18) in countries with collective bargaining. However, these associations varied across employment status. More generous wage-setting policies (e.g., collective bargaining or high minimum wages) were associated with lower food insecurity among full-time workers (and, to some extent, part-time workers) but not those who were unemployed.

Conclusions. In countries with generous wage-setting policies, employed adults had a lower risk of food insecurity, but the risk of food insecurity for the unemployed was unchanged. Wage-setting policies may be an important intervention for addressing risks of food insecurity among low-income workers.
Effects of early mobilization (EM) in patients with noninvasive positive pressure ventilation (NIPPV) in Intensive Care Unit (ICU): a randomized controlled trial
Authors: Wang Yanhao , Huang Zixuan , Duan Jun , Xu Wenxin , Mao Jiayi , Yan Xiaoying , Yang Qin , Chen Jianli , Mou Shaoyu , Lan Rong
Published: February 2021

Background

Early mobilization (EM) may be an effective intervention for the promotion of rehabilitation in noninvasive positive pressure ventilation (NIPPV) patients. The aim of this study was to investigate the effects of EM in patients with NIPPV in Intensive Care Unit (ICU).
Methods

Participants were randomly allocated to the intervention group involving active and passive activities combined with routine treatments and the control group with routine treatments in this single-center, parallel-designed randomized controlled trial. Participants accepted initiative and passive activities following brought by medical and nursing team who were standardized training The primary outcomes were the incidence of ICU-AW, length of ICU stay, duration of ventilation and mortality.
Results

There were no adverse event in participants during EM. Compared with the control group, there was a significantly lower length of ICU stay (m = 6.0 vs 7.8 days, respectively, P = 0.038), incidence of ICU-acquired weakness (n = 17.4% vs 50%, respectively, P = 0.026), duration of ventilation (m = 2.1 vs 4.0 days, respectively, P = 0.019) in the intervention group.
Conclusions

EM is feasible and safe in noninvasive ventilator patients, it can decrease the incidence of ICU-acquired weakness, length of stay and duration of noninvasive ventilation in ICU, and promoted the recovery of grip strength.
Methylene Blue has a potent antiviral activity against SARS-CoV-2 and H1N1 influenza virus in the absence of UV-activation in vitro
Authors:   Valeria Cagno1, Medaglia Chiara , Cerny Andreas , Cerny Thomas , Zwygart Arnaud , Cerny Erich , Tapparel Caroline
Published: February 2021

Methylene blue is an FDA (food and drug administration) and EMA (european medicines agency) approved drug with an excellent safety profile. It displays broad-spectrum virucidal activity in the presence of UV light and has been shown to be effective in inactivating various viruses in blood products prior to transfusions. In addition, its use has been validated for methemoglobinemia and malaria treatment. In this study, we first evaluated the virucidal activity of methylene blue against Influenza Virus H1N1 upon different incubation times and in the presence or absence of light activation, and then against SARS-CoV-2. We further assessed the therapeutic activity of methylene blue by administering it to cells previously infected with SARS-CoV-2. Finally, we examined the effect of co-administration of the drug together with immune serum.
Our findings reveal that methylene blue displays virucidal preventive or therapeutic activity against Influenza Virus H1N1 and SARS-CoV-2 at low micromolar concentrations and in the absence of UV activation. We also confirm that MB antiviral activity is based on several mechanisms of action as the degradation of genomic RNA is only observed in the presence of light and after long exposure. Our work supports the interest of testing methylene blue in clinical studies to confirm a preventive or therapeutic efficacy against both Influenza Virus H1N1 and SARS-CoV-2 infections.
How is Dignity Understood and Preserved in Patients with Palliative Needs in the Middle East? An Integrative Review
Authors: Sailian Silva Dakessian , Salifu Yakubu , Saad Rima , Preston Nancy
Published: February 2021

Background: Patients with palliative needs experience high psychological and symptom distress that may lead to hopelessness and impaired sense of dignity. Maintaining patient dignity or the quality of being valued is a core aim in palliative care. The notion of dignity is often explained by functionality, symptom relief and autonomy in decision making. However, this understanding and its implications in Middle Eastern countries is not clear.The aim of this review is to 1) explore the understanding of dignity and how dignity is preserved in adult patients with palliative care needs in the Middle East 2) critically assess the findings against the Dignity Model dominant in western literature.Method: Using an integrative review we searched four databases EMBASE, Psych-Info, CINAHL, and PubMed. These databases retrieve a broad literature on palliative care and are often chosen in other palliative care reviews. To enhance the search strategy, three online journals were hand searched, reference lists of review papers scanned, and forward citations sought. No time limits were applied. The retrieved papers were assessed independently by two authors including quality assessment using the Hawker’s appraisal tool.Results: Out of the 5113 studies retrieved, 294 full texts were assessed. Sixteen studies were included for synthesis of which fourteen were published in Iran. Seven themes were developed after data analysis: Maintaining Privacy and Secrecy; Gentle communication with a dialogue that preserves hope instead of blunt truth-telling; Abundance characterised by accessibility to medical supplies and financial stability; Family Support where relatives deliver major assistance in care; Physical Fitness; Reliable health care, and Social justice that endorses equal care to all.Conclusion: The results are compatible with the existing evidence from the Dignity Model ascertaining that dignity is socially mediated and influenced by interactions and physical fitness. Nevertheless, the findings highlight that patient dignity is also shaped by the socio-political, cultural, and economic conditions of the country, where family support, gentle communication and accessible health care are essential elements.
Epigenetic Events and Germ Line Transmission in Rag1 knock-out Chimeric Mice Produced by CRISPR/Cas9 Technology
Authors: Salimi Maryam , Mehravar Maryam , Shirazi Abolfazl , Sarvari Ali , Naderi Mohammad Mahdi , Malekpour Ali , Mehrazar Mohammad Mehdi , Majidi Mohammad , Behzadi Bahareh
Published: February 2021

Considering the effects of epigenetic changes on the embryonic development through altering the gene expression of pluripotency, trophectoderm, and imprinting genes, we determined the pattern of epigenetic alterations in transgenic embryos produced by injecting transgenic mESCs into the morula. To aim this, RAG1 knock-out mESCs were produced using CRISPR-Cas9 editing system and then microinjected into morulas to develop chimeric embryos. Afterward, the expression of pluripotency, trophectoderm genes, and imprinting genes in these embryos were evaluated using real-time PCR. Immunohistochemical analysis was carried out to determine the methylation rates of H3K9me3 and H3K4me3. In the following, since epigenetic alterations can be at least one of the possible reasons of male infertility and the loss of germ-line transmission capacity, the germ-line transmission ability in chimeric mice was also evaluated by breeding them and subsequent backcrosses to wild type strains. Our findings showed that the methylation rates of H3K4me3 and H3K9me3 were significantly lower and higher respectively in the RAG1 knock-out embryos compared others groups. Moreover, the chimeric embryos exhibited the decreased expression of NANOG, OCT4, CDX2, TEAD4, and H19 genes. Following the breeding of chimeric males with normal female mouse, 40% of chimeras had no germ-line transmission (GLT), and 60% were infertile.We showed that the manipulation of mESC by CRISPR-Cas9 approach remarkably changed the methylation status of H3K9me3 and H3K4me3, resulting in impaired development of embryos through dysregulation of genes involved embryonic development and then, may be one of the reasons of infertility and lack of GLT.
Prediction of COVID-19 status using baseline demographics and lab data
Authors: Zhang Jimmy , Jun Tomi , Frank Jordi , Nirenberg Sharon , Kovatch Patricia , Huang Kuan-lin
Published: February 2021

The global surge in COVID-19 cases underscores the need for fast, scalable, and reliable testing. Current COVID-19 diagnostic tests are limited by turnaround time, limited availability, or occasional false findings. Here, we developed a machine learning-based framework for predicting COVID-19 positive test status relying only on readily-available baseline data, including patient demographics, comorbidities, and common lab values. Leveraging a cohort of 31,739 adults within an academic health system, we trained and tested multiple types of machine learning models, achieving an area under the curve of 0.75. Feature importance analyses highlighted serum calcium levels, aspartate aminotransferase levels, and oxygen saturation as key predictors. Additionally, we developed a single decision tree model that provided an operable method for stratifying sub-populations. Overall, this study provides a proof-of-concept that COVID-19 status prediction models can be developed using only baseline data. The resulting prediction can complement existing tests to enhance screening and pandemic containment workflows.