bluuebunny/crossref_metadata_2025 huggingface dataset:
“I Grew Up Amidst Alcohol and Drugs:” a Qualitative Study on the Lived Experiences of Parental Substance Use Among Adults Who Developed Substance Use Disorders Themselves
Authors: Meulewaeter Florien , De Schauwer Elisabeth , De Pauw Sarah S. W. , Vanderplasschen Wouter
Published: February 2022

Experiencing parental substance use (PSU) has been associated with a heightened risk of developing substance use disorders (SUDs) in offspring. The primary goal of this study was to explore perspectives of adult children with lived experience of PSU who also developed SUDs themselves through first-hand experience. This study was conducted in Flanders (Belgium). A qualitative exploratory research design was applied. Seventeen semi-structured interviews were conducted with adult children of parents with SUDs (range: 29–48 years) who themselves had developed SUDs. All interviews were audio-taped and transcribed verbatim. Three overarching themes emerged through thematic analysis: 1) loneliness and neglect in childhood; 2) stigma and the self; and 3) the role of social connection in substance use and recovery. The narratives highlighted the central role of feelings of loneliness, isolation and belonging among children of parents with SUDs in childhood and adulthood. Increasing public awareness on the impact of PSU on children and accessible support is needed to overcome stigma and remove barriers to social inclusion for children of parents with SUDs. Findings may prove valuable in informing policy, program and treatment development aimed at breaking maladaptive intergenerational cycles.
Impact of Contextual Factors on the Attendance and Role in the Evidence-Based Chronic Disease Prevention Programs Among Primary Care Practitioners in Shanghai, China
Authors: Liu Xin , Gong Xin , Gao Xiang , Wang Zhaoxin , Lu Sheng , Chen Chen , Jin Hua , Chen Ning , Yang Yan , Cai Meiyu , Shi Jianwei
Published: February 2022

Background

The implementation of evidence-based approaches by general practitioners (GPs) is new in the primary care setting, and few quantitative studies have evaluated the impact of contextual factors on the attendance of these approaches.

Methods

In total, 892 GPs from 75 community healthcare centers (CHCs) in Shanghai completed our survey. We used logistic regression to analyze factors affecting the number of evidence-based chronic disease programs attended by GPs and whether they had held the lead position in such a program.

Results

A total of 346 (38.8%) of the practitioners had never participated in any evidence-based chronic disease prevention (EBCDP) program. The EBCDP interventions in which the GPs had participated were predominantly related to hypertension, diabetes, and cardiovascular disease. However, the proportion of GPs in the lead role was relatively low, between 0.8% (programs involving prevention and control of asthma) and 5.0% (diabetes). Organizational factors and areas were significantly associated with evidence-based practices (EBPs) of the GP, while monthly income and department were the most significantly related to GPs who have the lead role in a program. The results indicated that GPs who had taken the lead position had higher scores for policy and economic impeding factors. GPs who were men, had a higher income, and worked in prevention and healthcare departments and urban areas were more likely to take the lead position.

Conclusion

Evidence-based programs for chronic diseases should be extended to different types of diseases. Personal, organizational, political, and economic factors and the factors of female sex, lower income, department type, and suburban area environment should be considered to facilitate the translation of evidence to practice.
Physical Activity Levels of a Multi-Ethnic Population of Young Men Living in Saudi Arabia and Factors Associated With Physical Inactivity
Authors: AlTamimi Jozaa Z. , Alagal Reham I. , AlKehayez Nora M. , Alshwaiyat Naseem M. , Al-Jamal Hamid A. , AlFaris Nora A.
Published: February 2022

Objective

Regular physical activity is essential for lifelong optimal health. Contrarily, physical inactivity is linked with risk for many chronic diseases. This study was conducted to evaluate the physical activity levels and factors associated with physical inactivity among a multi-ethnic population of young men living in Saudi Arabia.

Methods

This is a cross-sectional study involving 3,600 young men (20–35 years) living in Riyadh, Saudi Arabia. Sociodemographic and physical activity data were collected from subjects by face-to-face interviews. Physical activity characteristics were evaluated by using the Global Physical Activity Questionnaire. Weight and height were measured following standardized methods, then body mass index was calculated.

Results

Physical inactivity was reported among 24.9% of study subjects. The lowest and highest rates of physical inactivity were reported among subjects from the Philippines (14.0%) and Saudi Arabia (41.5%), respectively. There is a high variation in daily minutes spent on physical activities related to work, transport, recreation, vigorous and moderate-intensity physical activities and sedentary behaviors among study participants based on their nationalities. Nationality, increasing age, longer residency period in Saudi Arabia, living within a family household, having a high education level, earning a high monthly income, and increasing body mass index were significantly associated with a higher risk of physical inactivity among the study participants.

Conclusion

Physical inactivity prevalence is relatively high among a multi-ethnic population of young men living in Saudi Arabia. The findings confirmed notable disparities in the physical activity characteristics among participants from different countries living in Saudi Arabia.
COVID-19 Vaccination Does Not Affect Reproductive Health Parameters in Men
Authors: Reschini Marco , Pagliardini Luca , Boeri Luca , Piazzini Francesca , Bandini Veronica , Fornelli Gianfranco , Dolci Carolina , Cermisoni Greta Chiara , Viganò Paola , Somigliana Edgardo , Coccia Maria Elisabetta , Papaleo Enrico
Published: February 2022

With the implementation of COVID-19 vaccine up-take, doubts regarding the impact of immunization on future fertility have begun to emerge. We have examined vaccine safety on male reproductive health. We set up a multicentre (three infertility centers), retrospective study in order to assess semen parameters and fertilization rate of one hundred-six men in a pairwise comparison between the first and second assisted reproduction technology (ART) attempt, performed respectively before and after COVID-19 vaccination. Median time (range) between the first vaccine dose and the second ART cycle was 75 days (39–112). Semen parameters did not change before and after the exposure. Fertilization rate was also similar before and after vaccination. Twenty-five patients (24%) were oligozoospermic before the vaccination while 26 (25%) after the exposure (P = 0.87). Severe asthenozoospermia were present in 11 patients before as well as after the exposure. No difference was observed even after considering different types of vaccines (mRNA or viral vector). COVID-19 vaccination did not affect sperm quality and fertilization capacity of men undergoing ART treatments and should be considered safe for men's reproductive health.
Professors Prioritize Increasing Female Retention in Academic Physics Over Advisee’s Interests
Authors: Bailey Kimberlyn , Horacek David , Worthington Steven , Schmitz Melissa
Published: February 2022

Decades of initiatives have striven to fix the so-called “leaking pipeline” problem—persistent high attrition of women from the career/educational path toward STEM professorship. Though these initiatives call on academics to increase female retention along this path, it remains unknown whether academics actually prioritize this goal. To investigate this, we tested whether academics would prioritize female retention at the cost of a competing goal when giving career advice to students at risk of leaving the “pipeline.” We present results from a national survey in which United States professors (n = 364) responded to vignettes of three hypothetical undergraduates, rating the extent to which they would encourage or discourage each student from pursuing a PhD in physics. Professors were randomly assigned vignettes with either male or female gender pronouns. Two vignettes featured students who cogently explained why remaining in the physics pipeline would not match their individual goals and interests, while another vignette presented a student with goals and interests that clearly matched pursuing physics graduate school. Professors who received female-gendered vignettes were thus forced to choose between prioritizing striving to increase female retention in physics and acting in the best interest of the individual student. We present evidence that professors seem prepared to encourage women more strongly than men to remain in physics, even when remaining is contrary to the stated goals and interests of the student: Our logistic regression results suggest that professors have higher odds of encouraging women over men, net of vignette and other controls. We also find that male professors have higher odds of encouraging undergraduates and find no evidence that, relative to non-STEM professors, STEM professors have higher odds of encouraging women over men.
Predictive Factors for Drain Placement After Laparoscopic Cholecystectomy
Authors: Calini Giacomo , Brollo Pier Paolo , Quattrin Rosanna , Bresadola Vittorio
Published: February 2022

Purpose

Currently, surgical drainage during a laparoscopic cholecystectomy (LC) is still placed in selected patients. Evidence of the non-beneficial effect of the surgical drain comes from studies with a heterogeneous population. This preliminary study aims to identify any clinical, demographic, or intraoperative predictive factors for a surgical drain placement during LC as the first step to identify population for a prospective randomized study.

Method

The study was conducted in a single referral center and academic hospital between 2014 and 2018. Patients who underwent unconverted LC were divided into two groups: Group A (drain) and Group B (no drain). We explored baseline, preoperative, intraoperative characteristics, and postoperative outcomes.

Results

Between 409 patients who underwent LC: 90 (22%) patients were in Group A (drain). Age >64 years, male sex, cholecystitis, Charlson comorbidity index (CCI) ≥ 1, experienced surgeon, intraoperative technical difficulties, need for an additional trocar, operative time >60 min, and estimated blood loss >10 ml were predictive factors at univariate analysis. While at multivariate analysis, cholecystitis (odds ratio [OR]: 2.8, 95% CI:1.5–5.1; p < 0.001), CCI ≥ 1 (OR:1.9, 95% CI:1.0–3.5; p = 0.05), intraoperative technical difficulties (OR: 3.6, 95% CI:1.8–6.2; p < 0.001), need of an additional trocar (OR: 2.5, 95% CI: 1.4–4.4; p < 0.005), and estimated blood loss >10 ml (OR: 3.0, 95% CI:1.7–5.3; p < 0.0001) were predictive factors for a surgical drain placement during LC.

Conclusions

This study identified predictive factors that currently drive the surgeons to a surgical drain placement after LC. Randomized prospective studies are needed to define the use of drain placement in these selected patients.
Staged Hybrid Techniques With Straightforward Bypass Surgery Followed by Flow Diverter Deployment for Complex Recurrent Middle Cerebral Artery Aneurysms
Authors: Tanabe Jun , Nakahara Ichiro , Matsumoto Shoji , Morioka Jun , Hasebe Akiko , Watanabe Sadayoshi , Suyama Kenichiro , Kuwahara Kiyonori
Published: February 2022

Background

Recurrent complex middle cerebral artery (MCA) aneurysms after combined clipping and endovascular surgery are challenging, and if conventional techniques are adapted, advanced surgical, endovascular, and a combination of both techniques are often required. For such complex aneurysms, safe and effective straightforward techniques for all neurovascular surgeons are warranted. We describe the details of staged hybrid techniques with straightforward bypass surgery followed by flow diverter deployment in a patient with complex MCA aneurysm.

Illustrative Case

A 69-year-old woman presented with left recurrent large MCA aneurysm enlargement 25 years after direct surgery and coil embolization for ruptured aneurysm. The recurrent MCA aneurysm had large and complex morphology and was adhering to the brain tissues. Therefore, it was unsuitable to treat such aneurysm with conventional surgical and endovascular techniques with a high risk of morbidity. We performed (1) M2 ligation following superficial temporal artery-M2 bypass and (2) flow diverter deployment assisted with coil packing in two sessions. Three months after the second session, the aneurysm was completely occluded with endothelialization of the neck. Angiographic findings revealed no recurrence 12 months after the treatment.

Conclusions

Staged hybrid techniques with straightforward bypass surgery followed by flow diverter deployment may be a safe and effective treatment for complex recurrent MCA aneurysms.
Efficacy of New Local Bacterial Agents against Pyrenophora tritici-repentis in Kuban Region, Russia
Authors: Asaturova Anzhela , Zhevnova Natalya , Tomashevich Natalya , Pavlova Marina , Kremneva Oksana , Volkova Galina , Sidorov Nikita
Published: February 2022

The phytopathogenic fungus Pyrenophora tritici-repentis is a causal agent of tan spot. Antagonistic microorganisms can be used as a non-chemical alternative treatment against the tan spot of wheat. Bacillus velezensis BZR 336 g and BZR 517 stains were selected as the most active microorganisms and potential biocontrol agents. We found that B. velezensis strains BZR 336 g and BZR 517 exhibited antagonistic activity against P. tritici-repentis Kr-15/2016 in vitro: they inhibited mycelium growth by 72.4–94.3% and caused its degenerative changes. Treatment of seeds and plants with strains BZR 336 g and BZR 517 provided a biological efficiency of 31.2–38.4% against tan spot, while artificial inoculation of plants provided only 28.4–43.8% biological efficiency. Treatment of seeds and plants with BZR 336 g and BZR 517 in a three-year field trial demonstrated 24.6–50% biological efficiency. BZR 336 g and BZR 517 provided 5.0–7.6% additional yield. We conclude that BZR 336 g and BZR 517 are promising options for novel bioproducts that can control P. tritici-repentis tan spot.
Applied Machine Learning on Phase of Gait Classification and Joint-Moment Regression
Authors: Jung Erik , Lin Cheryl , Contreras Martin , Teodorescu Mircea
Published: February 2022

Traditionally, monitoring biomechanics parameters requires a significant amount of sensors to track exercises such as gait. Both research and clinical studies have relied on intricate motion capture studios to yield precise measurements of movement. We propose a method that captures motion independently of optical hardware with the specific goal of identifying the phases of gait using joint angle measurement approaches like IMU (inertial measurement units) sensors. We are proposing a machine learning approach to progressively reduce the feature number (joint angles) required to classify the phases of gait without a significant drop in accuracy. We found that reducing the feature number from six (every joint used) to three reduces the mean classification accuracy by only 4.04%, while reducing the feature number from three to two drops mean classification accuracy by 7.46%. We extended gait phase classification by using the biomechanics simulation package, OpenSim, to generalize a set of required maximum joint moments to transition between phases. We believe this method could be used for applications other than monitoring the phases of gait with direct application to medical and assistive technology fields.
Carbon Monoxide (CO) as a Retinal Regulator of Heme Oxygenases -1, and -2 (HO’s) Expression
Authors: Nowak Sławomir , Gilun Przemysław , Kozioł Katarzyna , Romerowicz-Misielak Maria , Koziorowska-Gilun Magdalena , Wąsowska Barbara
Published: February 2022

Carbon monoxide (CO) has been proposed as a chemical light signal and neural system modulator via heme oxygenases -1 and -2 (HO-1 and HO-2). Many papers have proven the CO-HO circuit to be important for such physiological pathways as the molecular biological clock and the GnRH axis, but also in such pathological occurrences as ischemic injuries, or inflammation as a regenerative and neuroprotective factor. In this in vivo experiment, we used three groups of pigs: control—housed in natural conditions without any procedures; without CO—adapted and kept in constant darkness, infused with blank plasma; and with CO—adapted and kept in constant darkness infused with CO-enriched plasma. After the experiments, each animal was slaughtered and its eyes were collected for further analysis. Quantitative PCR and Western blot analysis were performed to show statistical differences in the expressions between the experimental groups. Our data revealed that exogenous CO is regulator of mRNA transcription for HO-1 and HO-2 and PCNA. Moreover, the mRNA abundance of analyzed factors in the experimental group after CO elevation revealed a restored gene-expression level similar to the control group, which we had observed in the group’s restored protein level after CO elevation. In conclusion, exogenous CO regulates HO’s and PCNA gene expression on transcriptional and translational levels in a similar way as a light cue.
Equal Efficacy and Safety Profile in Elderly Patients with Hepatocellular Carcinoma Receiving Palliative Treatment
Authors: Fründt Thorben W. , Casar Christian , von Felden Johann , Schöler Ulrike , Priebe Maximilian , Kraczyk Jenny , Ahrend Hannes , Salamon Johannes , Adam Gerhard , Huber Samuel , Lohse Ansgar W. , Wege Henning , Schulze Kornelius
Published: February 2022

Palliative treatment of elderly patients with hepatocellular carcinoma (HCC) is often challenging due to comorbidities or frailty, and data about the outcome and overall survival (OS) in these patients are limited. This was a retrospective single centre study. Patients were grouped according to their age as young (<60 years; YP), intermediate (60–70 years; IP) or elderly (>70 years; EP). Administration of chemotherapy or transarterial chemoembolization (TACE) was defined as palliative treatment. Therapy-related adverse events (AE) were assessed via CTCAE 5.0. Out of 656 patients analyzed, n = 359 received palliative treatment: YP: n = 90; IP: n = 127 and EP: n = 142. The median OS (months) in patients receiving TACE (n = 254) was 17 vs. 18 vs. 20 months for YP, IP, and EP, respectively (p = 0.44) and 15 vs. 16 vs. 17 months (p = 0.56), respectively, in patients receiving chemotherapy (n = 105). AEs differed non-significantly between the subgroups. Multivariate analysis revealed impaired liver function and advanced tumor stage as significant factors for impaired OS. In this study, the mOS and rate of AEs were equal between elderly and younger HCC patients receiving palliative treatment. Therefore, we propose regular palliative treatment stratification in spite of the high age of patients.
Species and Competition Interact to Influence Seasonal Stem Growth in Temperate Eucalypts
Authors: Plumanns-Pouton Ella , Bennett Lauren T. , Najera-Umaña Julio C. , Griebel Anne , Hinko-Najera Nina
Published: February 2022

Insights on tree species and competition effects on seasonal stem growth are critical to understanding the impacts of changing climates on tree productivity, particularly for eucalypts species that occur in narrow climatic niches and have unreliable tree rings. To improve our understanding of climate effects on forest productivity, we examined the relative importance of species, competition and climate to the seasonal stem growth of co-occurring temperate eucalypts. We measured monthly stem growth of three eucalypts (Eucalyptus obliqua, E. radiata, and E. rubida) over four years in a natural mixed-species forest in south-eastern Australia, examining the relative influences of species, competition index (CI) and climate variables on the seasonal basal area increment (BAI). Seasonal BAI varied with species and CI, and was greatest in spring and/or autumn, and lowest in summer. Our study highlights the interactive effects of species and competition on the seasonal stem growth of temperate eucalypts, clearly indicating that competitive effects are strongest when conditions are favourable to growth (spring and autumn), and least pronounced in summer, when reduced BAI was associated with less rainfall. Thus, our study indicates that management to reduce inter-tree competition would have minimal influence on stem growth during less favourable (i.e., drier) periods.
What Do Consumers Think About Foods Processed by Ultraviolet Radiation and Ultrasound?
Authors: Monteiro Maria Lúcia G. , Deliza Rosires , Mársico Eliane T. , de Alcantara Marcela , de Castro Isabele P. L. , Conte-Junior Carlos A.
Published: February 2022

This study aimed to investigate Brazilian consumers’ perception concerning foods processed by ultraviolet (UV) radiation and ultrasound (US) and define consumer segments considering their socioeconomic characteristics and eating habits towards industrialized products through free word association tasks answered by 1004 participants via an online platform. UV- and US-treated foods were more frequently related to unfamiliar words/terms (21.51 and 36.95%) and negative associations (36.25 and 26.70%) than positive ones (29.89 and 24.20%), respectively. Unfamiliarity and health risk concerns were more reported for US-treated foods by women aged 18–25 and ≥46 with low income, and low and frequent industrialized products consumption, as well as for UV-treated foods by consumers ≤35 years old with low and medium income, and low and frequent industrialized products consumption. This indicates that more clear and trustworthy information is needed before introducing these products in the Brazilian market, mainly for potential target consumer groups identified in this study.
Optimization of Raw Ewes’ Milk High-Pressure Pre-Treatment for Improved Production of Raw Milk Cheese
Authors: Inácio Rita S. , Barros Rui , Saraiva Jorge A. , Gomes Ana M. P.
Published: February 2022

Serra da Estrela protected designation of origin (PDO) cheese is manufactured with raw milk from Bordaleira and/or Churra Mondegueira da Serra da Estrela sheep breeds. Several socio-environmental shortcomings have reduced production capacity; hence, treatments that may contribute to its efficient transformation into cheese are welcome. High-pressure processing (HPP) milk pre-treatment may contribute to a cheese yield increment, yet optimization of processing conditions is warranted. An initial wide-scope screening experiment allowed for pinpointing pressure intensity, holding time under pressure and time after HPP as the most important factors influencing curd yield. Based on this, a more targeted screening experiment allowed for selecting the range of experimental conditions to be used for an experimental design study that revealed an HPP treatment at 121 MPa for 30 min as the optimum for milk processing to improve curd yield (>9%) and effectively maintain the beneficial cheese microbiota; the optimum was validated in a final experimental framework.
Identification of the CesA Subfamily and Functional Analysis of GhMCesA35 in Gossypium hirsutum L.
Authors: Zhao Ruolin , Cheng Hailiang , Wang Qiaolian , Lv Limin , Zhang Youping , Song Guoli , Zuo Dongyun
Published: February 2022

The cellulose synthase genes control the biosynthesis of cellulose in plants. Nonetheless, the gene family members of CesA have not been identified in the newly assembled genome of Gossypiumhirsutum (AD1, HEBAU_NDM8). We identified 38 CesA genes in G. hirsutum (NDM8) and found that the protein sequence of GhMCesA35 is 100% identical to CelA1 in a previous study. It is already known that CelA1 is involved in cellulose biosynthesis in vitro. However, the function of this gene in vivo has not been validated. In this study, we verified the function of GhMCesA35 in vivo based on overexpressed Arabidopsis thaliana. In addition, we found that it interacted with GhCesA7 through the yeast two-hybrid assay. This study provides new insights for studying the biological functions of CesA genes in G. hirsutum, thereby improving cotton fiber quality and yield.
Psychometric Assessment of the Need Satisfaction and Frustration Scale with Professional Romanian Athletes
Authors: Alexe Dan Iulian , Abalasei Beatrice Aurelia , Mares Gabriel , Rata Bogdan Constantin , Iconomescu Teodora Mihaela , Mitrache Georgeta , Burgueño Rafael
Published: February 2022

Background: Although athletes’ experiences of autonomy, competence, and relatedness play in key role in their motivation, performance-related outcomes, and wellness, there is no evidence to date on measures of autonomy, competence, and relatedness in the Romanian sport context. Building upon self-determination theory, the objective of this research was to adapt the Need Satisfaction and Frustration Scale and analyze its psychometric properties in the Romanian sport context. Methods: The participants were 642 professional athletes (354 males and 288 females; Mage = 22.81, SD = 5.78) who competed at the international and/or national level. Results: The results from confirmatory factor analyses psychometrically supported a six-factor correlated model, which was invariant across gender, age, and sport. Convergent validity was met by average variance extracted values between 0.60 and 0.74. Discriminant validity was underpinned by values from −0.72 to 0.72 for a heterotrait–monotrait ratio of correlations among the six factors. Reliability was endorsed by Cronbach’s alpha scores between 0.75 and 0.89, and between 0.76 and 0.89 for Raykov’s composite reliability coefficient. Criterion validity was supported by positive relationships of autonomy, competence, and relatedness satisfaction to autonomous motivation, and positive associations of autonomy, competence, and relatedness frustration with controlled motivation and amotivation. Conclusions: The Need Satisfaction and Frustration Scale is shown to be a valid and reliable measure of need satisfaction and frustration in professional Romanian athletes.
Acknowledgment to the Reviewers of the Journal of Nanotheranostics in 2021
Authors:   Journal of Nanotheranostics Editorial Office
Published: February 2022

Rigorous peer reviews are the basis of high-quality academic publishing [...]
The Effect of Scandium on the Structure, Microstructure and Superconductivity of Equimolar Sc-Hf-Nb-Ta-Ti-Zr Refractory High-Entropy Alloys
Authors: Krnel Mitja , Jelen Andreja , Vrtnik Stanislav , Luzar Jože , Gačnik Darja , Koželj Primož , Wencka Magdalena , Meden Anton , Hu Qiang , Guo Sheng , Dolinšek Janez
Published: February 2022

In this study, we investigate the scandium-containing Sc-Hf-Nb-Ta-Ti-Zr system of refractory high-entropy alloys (HEAs). Using the arc-melting method, we synthesized nine equimolar alloys (five 4-, three 5- and one 6-component), with all of them containing Sc. The alloys were characterized by XRD, electron microscopy and EDS, while superconductivity was investigated via electrical resistivity, specific heat and the Meissner effect. The results were compared to the parent Hf-Nb-Ta-Ti-Zr refractory HEAs, forming a single-phase body-centered cubic (bcc) structure and quite homogeneous microstructure. The addition of Sc produces a two-phase structure in the Sc-Hf-Nb-Ta-Ti-Zr alloys, with one phase being bcc and the other hexagonal close-packed (hcp). The hcp phase absorbs practically all Sc, whereas the Sc-poor bcc phase is identical to the bcc phase in the Hf-Nb-Ta-Ti-Zr parent system. Upon the Sc addition, the microstructure becomes very inhomogeneous. Large bcc dendrites (10–100 µm) are homogeneous in the central parts, but become a fine dispersion of sub-micron precipitates of the bcc and hcp phases close to the edges. The interdendritic regions are also a fine dispersion of the two phases. Superconductivity of the Sc-Hf-Nb-Ta-Ti-Zr alloys originates from the bcc phase fraction, which demonstrates identical superconducting parameters as the bcc Hf-Nb-Ta-Ti-Zr parent alloys, while the Sc-containing hcp phase fraction is non-superconducting.
Reuse of Red Mud and Bauxite Tailings Mud as Subgrade Materials from the Perspective of Mechanical Properties
Authors: Ou Xiaoduo , Chen Shengjin , Jiang Jie , Qin Jinxi , Zhang Lu
Published: February 2022

In order to reuse red mud and bauxite tailings mud (two typical aluminum industrial wastes) to reduce the occupation of land resources and environmental damage, these two wastes were combined to develop subgrade materials for the first time. With different combinations, the effects of the amounts of red mud, tailings mud, and cementitious materials on the strength of tested subgrade materials were investigated. The mechanism of strength growth was analyzed by a micro-test. The test results showed that the material strength of three combinations met the requirements when the unconfined compression strength (UCS) of all combinations increased with age. The UCS of the A1BC2 combination (the mass ratio of red mud and tailings mud was 2:1, the mass ratio of cement and quicklime was 1:1, and the mass ratio of waste and cementitious materials was 1:0.2) was the best, with the UCS being 3.03 MPa in 7 days. Microscopic imaging showed that specimens with high red mud contents had compact structures without cracks. The strength of these materials is mainly due to hydration reactions and pozzolanic reactions; the cementitious products generated by the reactions solidify Na+ and inhibit the release of OH−, while the addition of tailings mud can reduce the content of Na2O in the material, which makes the environmental compatibility of the A3BC2 combination the best (the mass ratio of red mud and tailings mud was 1:2, the mass ratio of cement and quicklime was 1:1, and the mass ratio of waste and cementitious materials was 1:0.2). Its pH value was 8.75. This experiment verifies the feasibility of the combined application of red mud and tailings mud in subgrade materials. To this end, a feasible scheme for the simultaneous consumption of these two kinds of aluminum industrial wastes has been proposed.
Mechanical Properties, Cytotoxicity, and Fluoride Ion Release Capacity of Bioactive Glass-Modified Methacrylate Resin Used in Three-Dimensional Printing Technology
Authors: Raszewski Zbigniew , Kulbacka Julita , Nowakowska-Toporowska Agnieszka
Published: February 2022

Background: Clinically, three-dimensional (3D) printing technology is becoming a popular and efficient dental processing technology. Recently, there has been an increasing demand for dental materials that exhibit bioactive properties. The present study aimed to evaluate the mechanical properties, cytotoxicity, and fluoride ion release capacity of 3D-printed dental resins modified with bioactive glass. Materials and methods: The resin FotoDent splint used in the production of removable orthodontic splints, was modified by the addition of two types of bioactive glasses that are capable of releasing fluoride ions. The novel materials used for the production of dental splints were examined for their mechanical, physical, and biological properties (fracture resistance, sorption, solubility, elution of nonpolymeric substances, and release of fluoride ions over time) and cytotoxic effects on cell cultures. Results: Initially, the fracture toughness of the 3D-printed resin was found to be 55 MPa, but after modification with glass, the resistance was reduced to about 50 MPa. Sorption and solubility values of the materials (19.01 ÷ 21.23 µg/mm3 and 0.42 ÷ 1.12 µg/mm3, respectively) complied with the safety limits imposed by ISO standard. Modified resins were capable of releasing fluoride ions, and the maximum releasing effect was observed after 14 days of incubation. Both the modified resins, after four days of contact with human gingival fibroblasts, exhibited moderate cytotoxic properties. Conclusions: The experimental results showed that modification of methacrylate resin, used in 3D printing technology, with bioactive glasses produces novel dental materials that possess desirable bioactive properties. The findings of this study indicate the potential ability of modified polymethacrylate resins to release fluoride ions in the oral cavity environment. The modified materials are characterized with a moderate decrease in physical properties and mild cytotoxicity on direct contact with human fibroblasts.
Effect of Tie Bars on Axial Compressive Behavior of Round-Ended Rectangular CFST Stub Columns
Authors: Ren Zhigang , Li Qi , Liu Chuang
Published: February 2022

Round-ended rectangular concrete-filled steel tube (RRCFST) columns are prone to local buckling that are close to straight steel plates when used as piers of a bridge and affect its long-term use. In order to solve this problem, tie bars were used in this research to stiffen RRCFST columns. Eleven specimens with tie bars and three specimens without tie bars were tested to analyze influences of cross-sectional aspect ratio, longitudinal spacing, limb numbers and diameter of the tie bar on failure model, confined effect, bearing capacity and ductility of RRCFST stub columns. Finite element models (FEM) with different concrete constitutive models for rectangular and circle parts were established and validated to reveal the mechanism of the constrained effect of tie bars. Experimental and FEM results show that the local buckling scope was decreased and gradually moved to middle height with decreased longitudinal spacings tie bars. The addition of tie bars in RRCFST columns with large aspect ratios slightly enhanced the ultimate bearing capacity, the diameter of tie bars changing from 8 mm to 12 mm greatly enhanced displacement and energy ductility by 58.4% and 85.1%, respectively. However, more tie bars (e.g., two or three limbs) utilization could not further improve the bearing capacity and failure mode. While, the tie bars had very limited contribution to bearing capacity and ductility for RRCFST columns with small aspect ratios, because the outer steel tubes already individually provided for enough confinement on inner concrete. By considering different concrete confined models for rectangular and round-ended parts, an analytical model was proposed and validated to predict the ultimate bearing load for RRCFST stub columns with tie bars.
Synthesis of Novel Nano-Sulfonamide Metal-Based Corrosion Inhibitor Surfactants
Authors: Khowdiary Manal M. , Taha Nahla A. , Saleh Nashwa M. , Elhenawy Ahmed A.
Published: February 2022

The synthesis of novel corrosion inhibitors and biocide metal complex nanoparticle surfactants was achieved through the reaction of sulfonamide with selenious acid to produce a quaternary ammonium salt. Platinum and cobalt surfactants were then formed by complexing the first products with platinum (II) or cobalt (II) ions. The surface properties of these surfactants were then investigated, and the free energy of form micelles (ΔGomic) and adsorption (ΔGoads) was determined. The obtained cationic compounds were evaluated as corrosion inhibitors for carbon steel dissolution in 1N HCl medium. The results of gravimetric and electrochemical measurements showed that the obtained inhibitors were excellent corrosion inhibitors. The anti-sulfate-reducing bacteria activity known to cause corrosion of oil pipes was obtained by the inhibition zone diameter method for the prepared compounds, which were measured against sulfate-reducing bacteria. FTIR spectra, elemental analysis, H1 NMR spectrum, and 13C labeling were performed to ensure the purity of the prepared compounds.
Magnetism of Tetragonal β-Fe3Se4 Nanoplates Controllably Synthesized by Thermal Decomposition of (β-Fe2Se3)4[Fe(tepa)] Hybrid
Authors: Kuang Qifeng , Men Xiaoling , Shang Xiaolei , Yang Bing , Zhou Yangtao , Zhang Bo , Li Zhiwei , Li Da , Zhang Zhidong
Published: February 2022

We report magnetism of tetragonal β-Fe3Se4 nanoplates controllably synthesized by thermal decomposition at 603 K of inorganic–organic (β-Fe2Se3)4[Fe(tepa)] hybrid nanoplates (tepa = tetraethylenepentamine). (β-Fe2Se3)4[Fe(tepa)] hybrid precursor and β-Fe3Se4 nanoplates are in single crystal features as characterized by selected area electron diffraction. Rietveld refinements reveal that ordered inorganic–organic (β-Fe2Se3)4[Fe(tepa)] hybrid nanoplates are in a tetragonal layered crystal structure with a space group of I4cm (108) and room-temperature lattice parameters are a = 8.642(0) Å and c = 19.40(3) Å, while the as-synthetic tetragonal β-Fe3Se4 nanoplates have a layered crystal structure with the P4/nmm space group, and room-temperature lattice parameters are a = 3.775(8) Å and c = 5.514(5) Å. Magnetic measurements show the weak ferrimagnetism for (β-Fe2Se3)4[Fe(tepa)] hybrid nanoplates at room temperature, while the as-synthetic β-Fe3Se4 nanoplates are antiferromagnetic in a temperature range between 120 and 420 K but in a ferrimagnetic feature below ~120 K. The as-synthetic β-Fe3Se4 nanoplates are thermally instable, which are transformed to ferrimagnetic β-Fe3Se4 nanoplates by annealing at 623 K (a little higher than the synthetic temperature). There is an irreversible change from antiferromagnetism of the as-synthetic β-Fe3Se4 phase to the ferrimagnetism of the as-annealed β-Fe3Se4 phase in a temperature between 420 and 470 K. Above 470 K, the tetragonal β-Fe3Se4 phase transforms to monoclinic Fe3Se4 phase with a Curie temperature (TC) of ~330 K. This discovery highlights that crystal structure and magnetism of Fe-Se binary compounds are highly dependent on both their phase compositions and synthesis procedures.
Comparative Study of Early Impacts of Post-COVID-19 Pneumonia on Clinical Manifestations, Pulmonary Function, and Chest Radiographs
Authors: Niyatiwatchanchai Nutchanok , Deesomchok Athavudh , Chaiwong Warawut , Duangjit Pilaiporn , Pothirat Chaicharn , Liwsrisakun Chalerm , Bumroongkit Chaiwat , Theerakittikul Theerakorn , Limsukon Atikun , Tajarernmuang Pattraporn , Trongtrakul Konlawij , Euathrongchit Juntima , Wannasopha Yutthaphan , Srisuwan Tanop
Published: February 2022

Background and Objectives: Scant data regarding early post-COVID-19 effects are available, especially in younger people. Therefore, the objective of this study was to explore the early clinical impacts of post-COVID-19 pneumonia, comparing severe and non-severe patients. Materials and Methods: A cross-sectional study was conducted in adult patients admitted with COVID-19 pneumonia from April to May 2021. Demographic data, symptoms and signs, quality of life, Hospital Anxiety and Depression Scale (HADS), chest radiograph (CXR), pulmonary function tests (spirometry, impulse oscillometry), fractional exhaled nitric oxide (FeNO), and exercise capacity were assessed one month after hospital discharge. Twenty-five healthy control subjects that were age- and gender-matched were recruited for comparisons. Results: One hundred and five patients, with a mean age of 35.6 ± 15.8 years and 54 (51.4%) males, participated and were categorized into the non-severe pneumonia (N = 68) and severe pneumonia groups (N = 37). At a one-month follow-up visit (the time from the onset of the disease symptoms = 45.4 ± 5.9 days), the severe group had more cough, fatigue, and skin rash with higher dyspnea scale, more residual CXR lesions, and lower quality of life scores. Forced vital capacity (FVC) was lower in the severe group (88.3% of predicted value) and non-severe group (94.6% of predicted value) than in the healthy controls (p = 0.001). The six-minute walk distance was significantly lower in the non-severe group, at 79.2 m, and in the severe group, at 103.8 m, than in the healthy control subjects (p < 0.001). Conclusions: Adult patients with COVID-19, especially those with clinically severe pneumonia, still had residual symptoms and chest radiographic abnormalities, together with poorer quality of life and lower exercise capacity, one month after hospital discharge.
The Added Value of Intraoperative Hypnosis during Spinal Cord Stimulation Lead Implantation under Awake Anesthesia in Patients Presenting with Refractory Chronic Pain
Authors: Wood Chantal , Martiné Gaëlle , Espagne-Dubreuilh Gaëlle , Le Goff Karine , Moens Maarten , Goudman Lisa , Baron Sandrine , David Romain , Naïditch Nicolas , Billot Maxime , Rigoard Philippe
Published: February 2022

To improve pain relief for refractory pain condition, spinal cord stimulation (SCS) needs to target the dedicated neuronal fibers within the dorsal columns. Intraoperative feedback from the patient can optimize lead placement but requires “awake surgery”, allowing interaction between patient and surgeon. This can produce negative effects like anxiety and stress. To better manage these aspects, we propose to combine intraoperative hypnosis with awake anesthesia. Seventy-four patients (35 females, 22–80 years) presenting with chronic refractory pain, were offered intraoperative hypnosis during awake SCS lead implantation. Interactive conversational hypnosis was used as well as interactive touch, which was enhanced during painful moments during the lead intraoperative programming. All patients participated actively during the intraoperative testing which helped to optimize the lead positioning. They kept an extremely positive memory of the surgery and of the hypnotic experience, despite some painful moments. Pain could be reduced in these patients by using interactions and touch, which works on Gate Control modulation. Positive memory was reinforced by congratulations to create self-confidence and to induce positive expectations, which could reinforce the Diffuse Noxious Inhibitory Controls at the spinal level. Cooperation was improved because the patient was actively participating and thus, much more alert when feedback was required. Combining intraoperative hypnosis with awake anesthesia appears helpful for SCS lead implantation. It enhances patient cooperation, allows optimization of lead positioning, and leads to better pain control, positive and resourceful memory.
New Method of Cardiac Lead Evaluation Using Chest Radiography
Authors: Mlynarski Rafal , Glowoc Sebastian , Mlynarska Agnieszka , Golba Krzysztof
Published: February 2022

Background and Objectives: There is currently no method that can be used for a precise evaluation of pacemaker leads using X-ray images, which could be a valuable add-on in the follow-up of patients. The aim of this paper was to create a simple method to measure selected points and lines using the chest radiography of patients with cardiac pacemakers. Materials and Methods: The study included 99 patients after permanent pacemaker implantation (72.0 ± 12.9 y; 58 W). The newly created method was used to evaluate the course of the leads based on an X-ray of the chest in an AP (posterior–anterior) projection (standing up) with optimization. The chest X-ray was applied to the original measurement grid, which was determined by specific anatomical points. For the purpose of this paper, a number of measurable parameters have been proposed. Results: The technical quality of the images was very good (4.50 ± 0.72). There were no gender-specific differences: women 4.46 ± 0.75/men 4.56 ± 0.67; p = 0.5183. The quality of the imaging of the leads was also good (3.72 ± 0.83), and no statistical differences were found between the genders. After verifying the technical quality of the X-ray images, the tract of the leads was measured. The only significant difference was found in parameter E—this value describing the so-called “death bend”, which was significantly lower in women (3.98 ± 1.35) vs. men (4.58 ± 1.49): p = 0.039. Conclusions: The presented method permitted the leads of a cardiac pacemaker to be precisely described with good clinical validity using chest radiography.
In Vitro Assessment of Antistaphylococci, Antitumor, Immunological and Structural Characterization of Acidic Bioactive Exopolysaccharides from Marine Bacillus cereus Isolated from Saudi Arabia
Authors: Selim Samy , Almuhayawi Mohammed S. , Alharbi Mohanned Talal , Nagshabandi Mohammed K. , Alanazi Awadh , Warrad Mona , Hagagy Nashwa , Ghareeb Ahmed , Ali Abdallah S.
Published: February 2022

A strain of Bacillus cereus was isolated from the Saudi Red Sea coast and identified based on culture features, biochemical characteristics, and phylogenetic analysis of 16S rRNA sequences. EPSR3 was a major fraction of exopolysaccharides (EPS) containing no sulfate and had uronic acid (28.7%). The monosaccharide composition of these fractions is composed of glucose, galacturonic acid, and arabinose with a molar ratio of 2.0: 0.8: 1.0, respectively. EPSR3 was subjected to antioxidant, antitumor, and anti-inflammatory activities. The results revealed that the whole antioxidant activity was 90.4 ± 1.6% at 1500 µg/mL after 120 min. So, the IC50 value against DPPH radical found about 500 µg/mL after 60 min. While using H2O2, the scavenging activity was 75.1 ± 1.9% at 1500 µg/mL after 60 min. The IC50 value against H2O2 radical found about 1500 µg/mL after 15 min. EPSR3 anticytotoxic effect on the proliferation of (Bladder carcinoma cell line) (T-24), (human breast carcinoma cell line) (MCF-7), and (human prostate carcinoma cell line) (PC-3) cells. The calculated IC50 for cell line T-24 was 121 ± 4.1 µg/mL, while the IC50 for cell line MCF-7 was 55.7 ± 2.3 µg/mL, and PC-3 was 61.4 ± 2.6 µg/mL. Anti-inflammatory activity was determined for EPSR3 using different methods as Lipoxygenase (LOX) inhibitory assay gave IC50 12.9 ± 1.3 µg/mL. While cyclooxygenase (COX-2) inhibitory test showed 29.6 ± 0.89 µg /mL. EPSR3 showed potent inhibitory activity against methicillin-resistant Staphylococcus aureus (MRSA) and coagulase-negative staphylococci. The exposure times of EPSR3 for the complete inhibition of cell viability of methicillin resistant S. aureus was found to be 5% at 60 min. Membrane stabilization inhibitory gave 35.4 ± 0.67 µg/mL. EPSR3 has antitumor activity with a reasonable margin of safety. The antitumor activity of EPSR3 may be attributed to its content from uronic acids with potential for cellular antioxidant and anticancer functional properties.
Automated Recommendation of Research Keywords from PubMed That Suggest the Molecular Mechanism Associated with Biomarker Metabolites
Authors: Kanazawa Shinji , Shimizu Satoshi , Kajihara Shigeki , Mukai Norio , Iida Junko , Matsuda Fumio
Published: February 2022

Metabolomics can help identify candidate biomarker metabolites whose levels are altered in response to disease development or drug administration. However, assessment of the underlying molecular mechanism is challenging considering it depends on the researcher’s knowledge. This study reports a novel method for the automated recommendation of keywords known in the literature that may be overlooked by researchers. The proposed method aided in the identification of Medical Subject Headings (MeSH) terms in PubMed using MeSH co-occurrence data. The intended users are biocurators who have identified specific biomarker metabolites from a metabolomics study and would like to identify literature-reported molecular mechanisms that are associated with both the metabolite and their research area of interest. The proposed method finds MeSH terms that co-occur with a MeSH term of the candidate biomarker metabolite as well as a MeSH term of a researcher’s known keyword, such as the name of a disease. The connectivity score S was determined using association analysis. Pilot analyses demonstrated that, while the biological significance of the obtained MeSH terms could not be guaranteed, the developed method can be useful for finding keywords to further investigate molecular mechanisms in association with candidate biomarker molecules.