bluuebunny/crossref_metadata_2025 huggingface dataset:
Sevoflurane postconditioning attenuates cardiomyocytes hypoxia/reoxygenation injury via PI3K/AKT pathway mediated HIF-1α to regulate the mitochondrial dynamic balance
Authors: Ma Haiping , Hou Tianliang , Wu Jianjiang , Zhao Jiyao , Cao Haoran , Masula Maisitanguli. , Wang Jiang
Published: July 2023

Background. Myocardial ischemia-reperfusion injury (I/RI) is a major cause of perioperative cardiac-related adverse events and death. Studies have shown that sevoflurane postconditioning (SpostC), which attenuates I/R injury and exerts cardioprotective effects, regulates mitochondrial dynamic balance via HIF-1α, but the exact mechanism is unknown. This study investigates whether the PI3K/AKT pathway in SpostC regulates mitochondrial dynamic balance by mediating HIF-1α, thereby exerting myocardial protective effects.
Methods. The H9C2 cardiomyocytes were cultured to establish the hypoxia-reoxygenation (H/R) model and randomly divided into 4 groups: normal control (Control) group, hypoxia-reoxygenation (H/R) group, sevoflurane postconditioning (H/R+SpostC) group and PI3K/AKT blocker (H/R+SpostC+LY) group. Cell survival rate was determined by CCK-8 method; apoptosis rate was determined by flow cytometry; mitochondrial membrane potential was evaluated by Mito Tracker™ Red; mRNA expression levels of AKT, HIF-1α, Opa1and Drp1 were detected by quantitative real-time polymerase chain reaction (qRT-PCR); Western Blot assay was used to detect the protein expression levels of AKT, phosphorylated AKT (p-AKT), HIF-1α, Opa1and Drp1.
Results. Compared with the H/R group, the survival rate of cardiomyocytes in the H/R+SpostC group increased, the apoptosis rate decreased and the mitochondrial membrane potential increased. qRT-PCR showed that the mRNA expression of HIF-1α and Opa1 were higher in the H/R+SpostC group compared with the H/R group, whereas the transcription level of Drp1 was lower in the H/R+SpostC group. In the H/R+SpostC+LY group, the mRNA expression of HIF-1α was lower than the H/R+SpostC group. There was no difference in the expression of Opa1 mRNA between the H/R group and the H/R+SpostC+LY group. WB assay results showed that compared with the H/R group, the protein expression levels of HIF-1α, Opa1, P-AKT were increased and Drp1 protein expression levels were decreased in the H/R+SpostC group. HIF-1α, P-AKT protein expression levels were decreased in the H/R+SpostC+LY group compared to the H/R+SpostC group.
Conclusion. SpostC mediates HIF-1α-regulated mitochondrial fission and fusion-related protein expression to maintain mitochondrial dynamic balance by activating the PI3K/AKT pathway and increasing AKT phosphorylation, thereby attenuating myocardial I/R injury.
Reduced graphene oxide-mediated electron-hole separation in titanium dioxide for boosting photocatalytic antibacterial activity of bone scaffold
Authors: Feng Pei , Tian Haifeng , Yang Feng , Peng Shuping , Pan Hao , Shuai Cijun
Published: July 2023

Fast electron-hole recombination in the photocatalysis process of titanium dioxide (TiO2) limits its antibacterial properties although TiO2 has great potential for preventing bacterial infection in bone defect repair because it has the ability to generate reactive oxygen species under ultraviolet irradiation to destroy bacteria. In this study, TiO2@rGO were synthesized through a hydrothermal method, where TiO2 was grown on reduced graphene oxide (rGO). Subsequently, TiO2@rGO composite powders were introduced into poly-l-lactic acid (PLLA) and then selective laser sintering was as a method for scaffold fabrication with photocatalytic antibacterial ability. It showed that TiO2 grew on the surface of rGO and formed a covalent bond connection (Ti-O-C) with rGO. The excellent conductivity of rGO promoted the separation of electron-hole pairs generated by TiO2 photocatalysis, resulting in a decrease in photoluminescence intensity that indicated an enhancement of TiO2 photocatalytic activity. In vitro antibacterial experiments indicated that the scaffold photocatalysis produced ·OH and ·O2− under ultraviolet irradiation, which destroyed the cell membrane structure and had antibacterial effects on both E. coli and S. aureus. Additionally, the scaffold exhibited enhanced mechanical properties due to the addition of TiO2@rGO as reinforcement phase and good biocompatibility for cell activity and proliferation.
Does Acuity and Severity of Injury Affect Trauma Whole-Body CT Report Turnaround Time? A Large-scale Study
Authors: Sarkar Nathan , Khedr Mustafa , Dreizin David
Published: July 2023

Trauma is a leading cause of death in the United States. Whole-Body CT is routinely used to screen for major injuries and hemorrhage and to plan interventions. Report Turn-Around-Time (RTAT) plays a role in the flow of patient management and is an objective marker of efficiency that could be improved upon with development and implementation of AI CAD tools for trauma patients. Currently, the degree to which this metric is affected by injury acuity and severity is poorly documented. The study included 11,251 patients who underwent admission trauma whole-body CT at two trauma centers within a single hospital system; a level I trauma center (n=9043) and a regional urban level II trauma center (n=2208). Patients were selected between July 2016 and September 2022. Clinical data and RTAT were extracted from the trauma registry and medical records. Overall median RTAT was 24 minutes (IQR: 4-48). RTAT was significantly longer in those who had hemodynamic shock (37 minutes vs 22 minutes, p<0.0001), polytrauma (ISS≥16) (34 minutes vs 21 minutes, p<0.0001), or massive transfusion (47.5 minutes vs 24 minutes, p<0.0001); those who expired (41 minutes vs 23 minutes,p<0.0001); the older cohort (age>55) (28 minutes vs 22 minutes, p<0.0001), and those with penetrating vs blunt injuries (27 minutes vs 23 minutes, p=0.001). Overall, these findings indicate that increased traumatic injury severity is associated with non-negligible increases in whole-body CT RTATs. The results provide strong justification for computer-aided detection/diagnosis (CAD) research and development to reduce cognitive load and augment diagnostic efficiency in severely injured patients who stand to benefit most from such tools.
Identification and classification of ATS in oral fluid based on Ag nanoassemblies on Si surface doped with Au nanobipyramids
Authors: Cui Sheng-Feng , Yang Hai-Long , Huang Xin , Wan Jing-Wei
Published: July 2023

Herein, a novel Ag NP substrate doped with Au nanobipyramids was designed and fabricated via a convenient procedure of galvanic reaction for the identification and classification of amphetamine-type stimulants (ATS) in oral fluids in combination with surface-enhanced Raman spectroscopy (SERS). The substrate was shown to have a three-dimensional nanostructure, high SERS activity, and good stability. In combination with SERS, the Ag NP substrate doped with Au nanobipyramids was able to detect ultra-low traces of ATS, including amphetamine, methylamphetamine, 3,4-methylenedioxyamphetamine, and 3,4-methylenedioxymethylamphetamine in oral fluid, with limit of detection values as low as 10–14 mg/mL, which is much better than the current spectroscopic techniques, and there exists a good negative linear relation between concentration and peaks intensity at nanogram (10–9 mg/mL) concentration level. In addition, multivariate analysis showed that partial least squares-discriminant analysis model could discriminate among different ATS. The approach can be broadly applied to the ultra-low trace detection of ATS and would be particularly useful for the analyses of nitrogenous organic compounds.
The control of hormogonia induction/suppression by the alteration of scmucilage signaling molecules in Cycas plant in an endosymbiotic cyanobacterium
Authors: Sanniyasi Elumalai , R Kreedika , Gopal Rajesh Kanna , Damodharan Rajesh , Raj Preethy P , Prakash Rejoy Antony
Published: July 2023

This study focuses on the role of mucilage signaling molecules secreted by the Cycad plant in the regulation of hormogonia induction/suppression in a novel endosymbiotic cyanobacterium (Cyanocohniella cycadae sp. nov.) isolated from the coralloid root of Cycas circinalis. Through a series of experiments using a combination of extraction, screening, acid-hydrolysis, derivatization, and GC-MS approaches, we sought to identify and characterize the mucilage signaling molecules secreted by Cycas circinalis and their role in the regulation of hormogonia induction/suppression in Cyanocohniella cycadae. Our results indicated that the mucilage components secreted in the coralloid root (CA) vary with the pre-coralloid root (PCA) of the same Cycas plant. Hence, we identified the presence of specific monosaccharides like arabinose (14.93 %), galactose (5.61 %), xylose (6.46 %), glucose (6.70 %), and altrose (4.41 %) in CA results in the suppression of hormogonia, whereas, glucose (29.86 %), fructose (18.86 %), talose (6.73 %), and lyxose (3.88 %) in PCA induces hormogonia development. Overall, this study provides new insight into the role of the alteration of mucilage signaling molecules. A shift between hexose and pentose in the pre-coralloid and coralloid root switches the induction and suppression of hormogonia in the cyanobacterium respectively. Further studies are needed to elucidate the mucilage biosynthetic pathways in the regulation of hormogonia induction/suppression in a variety of endosymbiotic cyanobacteria.
Transverse Mandibular Morphology in Different Sagittal Skeletal Malocclusions: A CBCT Study
Authors: Chalhoub Mohamad , Kanj Abdel Hadi , Osman Essam , KMEID Roland , Wak Terry El , Bouserhal Joseph
Published: July 2023

Objectives The study aimed to evaluate the mandibular width in males and females in different sagittal skeletal malocclusions (SSMs) using cone-beam-computed-tomography (CBCT).Materials and methods The study sample consisted of 90 CBCT scans of subjects (45 males and 45 females) aged between 18 and 40 years old with a mean age of 31.91 ± 7.61, divided into six equal groups with fifteen subjects each according to their SSM: Class I males and females (CIM, CIF), Class II males and females (CIIM, CIIF) and Class III males and females (CIIIM, CIIIF). Landmarks were identified on the axial plane as well as on the three-dimensional reconstructed views, then the distances between the right and left: condylar superior (CsupR-CsupL), Antegonions (AGR-AGL) and mental foramens (MFR-MFL) were measured using Dolphin imaging-software along with the following 2 angles: CsupR-AGR/CsupL-AGL and AGR-MFR/AGL-MFL. All relevant data were then analyzed with a two-way ANOVA.Results Mandibular width was significantly superior in males compared to females in all SSMs at the level of Csup, AG and MF, except in CII subjects at the MF area where it was higher in females. AGR-AGL as well as MFR-MRL distances was elevated in CIIIM compared to CIIM and CIM. CsupR-AGR/CsupL-AGL angle was smaller in CIIIF compared to CIF and CIIF subjects. AGR-MFR/AGL-MFL angle was higher in CIIM than that of CIIF.Conclusions Although the mandibular width increases in CIII malocclusion compared to CI and CII, the intercondylar distance does not significantly change.Clinical Relevance: Surgically facilitated orthodontic treatment (SFOT) can be a better alternative than mandibular distraction osteogenesis in class II transversally deficient mandibles as the latter increases the intercondylar width while the former does not.
Verifiable and privacy-preserving fine-grained data management in vehicular fog computing: A game theory-based approach
Authors: Seyedi Zahra , Rahmati Farhad , Ali Mohammad , Liu Ximeng
Published: July 2023

Vehicular fog computing (VFC) is an effective technology in providing end-users and vehicles with ultra-low-latency services by extending fog computing to regular vehicular networks. It enables connected Vehicular Fog Nodes (VFNs) to process real-time data and promptly respond to users’ queries. However, touching unencrypted data by VFNs raises security challenges definitely, the top of which is confidentiality, and giving encrypted data to VFNs causes other problems such as encrypted data processing. Apart from these, how to inspect and encourage VFNs to provide a secure, honest, and user-satisfactory network is of vital importance to this area. To address these challenges, we design a novel fine-grained data management (FGDM) approach for VFC-assisted systems. Our FGDM provides control over both retrieval and access to outsourced data in fine-grained ways. Also, it offers highly efficient approaches for the accuracy verification of operations performed by VFNs. In designing the system, we consider a three-player game among system entities to capture their interactions. We formulate the management problems as a Nash Equilibrium (NE) problem and show the existence of an equilibrium. Our security analysis and empirical results demonstrate that the FGDM is secure in the standard model and acceptably efficient.
New approach of creation and modifying the characteristics of AuNPs/MWCNT/PSi hybrid structures
Authors: Ali Samah G. , Alwan Alwan M. , Jabbar Allaa A.
Published: July 2023

In this paper, a new approach is presented on modifying the properties of hybrid structures of gold nanoparticles (AuNPs) and multi wall carbon nanotubes (MWCNT); deposited on morphologically controlled porous silicon (PSi) surface. The PSi layer was prepared by Photo-electrochemical etching using a current density between 15 to 30mA/cm2. The AuNPs/ MWCNT was decorated on a PSi surface by simple ion reduction from aqueous solutions of gold salt (HAuCl4) at 5\(\times\)10−2 M, 10− 2 M, 10− 3 M, and 10− 4 M concentrations. Structural, morphological and optical characterizations of (AuNPs/MWCNT/PSi) hybrid structure were analyzed with respect of the PSi layer morphology. The obtained results showed a possibility of effectively controlling the hybrid structures morphology, the AuNPs size and the surface area by controlling the pores’ diameters. The deposition of the MWCNT and AuNPs on the wall and pore may enhance the specific surface area of the hybrid structure. Moreover, the decrease of the concentration of the gold salt aqueous solution led a significant decrease of the AuNPs sizes, and this added another means to modify the hybrid structures.
A facile and on-demand optimizing strategy for polyurethane elastomers via programmable hydrogen bonding
Authors: Zou Meishuai , Bai Zichen , Li Xiaodong , Wu Tianhao , Jiang Hao , Zhang Xudong , Zhang Lichen , Yang Yi , Liu Shuang , Lei Lisha , Song Ningning , Wang Zhengdi , Su Xing
Published: July 2023

Polyurethane elastomers have advantages in terms of elasticity, toughness and oil-resistance because of its unique hydrogen bonding structure. It has been widely used in industry. However, the poor designability of hydrogen bonding structure in existing polyurethane elastomers severely restricts the on-demand regulation of their properties. Moreover, like most polymer materials, polyurethane elastomers are susceptible to heat or radiation induced aging which significantly limit their practical effectiveness. Herein, a facile, universal, efficient and programmable strategy based on physical modification of polyphenol aggregates was proposed, which could systematically improve the overall performance of engineering polyurethane elastomers. Through precisely manipulated heat-induced phase transition and/or photo-induced interfacial hydrogen bonding upgrading due to polyphenol aggregates, programmable strengthening and toughening effect could be achieved with high precision. Typically, the tensile strength and toughness of our proposed polyurethane elastomers could be enhanced by 3.23 and 2.22 times comparing with neat polyurethane samples, respectively. The relevant results were supported by various characterization and mathematical modeling. In addition, the polyurethane elastomers exhibited unique selective biocompatibility, rapid self-healing capability under mild conditions and nice recyclability, which could fulfill a variety of functions. Our proposed modifying strategy by using polyphenol aggregates can not only programmably optimize the comprehensive properties of polyurethane elastomers, but also inspire programmable regulation of polyurethane performance through programmable design of its certain microstructure in the future. Our proposed polyurethane materials hold big promise in the application of structure materials, programmable devices, artificial intelligence, biomedicine, environmental protection and etc.
Hopf bifurcation and patterns in a modified SIR model
Authors: Yang Wenjie , Zheng Qianqian , Shen Jianwei , Guan Linan
Published: July 2023

Infectious diseases have constantly threatened human safety because the diffusion of the susceptible and infected may make more individuals infected and even die. In this paper, a modified SIR model with both external stimulus and diffusion is considered to illustrate the dynamical mechanism of the periodic outbreak and pattern formation. Firstly, we propose a modified SIR model based on the propagation behavior of infectious diseases to show the effects of the different parameters and diffusion on the outbreak. The Hopf bifurcation and multiscale methods are performed to analyze the stability of this model, which explains the dynamical mechanism of the periodic outbreak. Then the pattern formation and Turing instability are discussed through comparison principles to reveal the role of periodic disturbances and diffusion in selecting pattern formation. Also, we find rich patterns that may occur when the frequency modulation is close to the intrinsic frequency. Finally, our theoretical results are verified by numerical simulation.
2010 MSC: 34F10, 35B36, 92C42.
Conditions Necessary for Optimizing the Performance of Volunteers in Sports Events
Authors: Asefi Ahmadali , Kameli Fatame
Published: July 2023

Volunteers play a crucial role in the success of sports events, and optimizing their performance can significantly impact the overall quality of the event. Therefore, the purpose of this study was to identify and prioritize the conditions necessary for optimizing the performance of volunteers in sports events. To achieve this objective, we reviewed relevant literature on volunteering and identified important factors for the optimal performance of volunteers in sports events. We then used the Best Worst Method (BWM) to determine the importance and weight of each factor. By addressing these factors, sports event managers can influence volunteer behavior and optimize their performance, ultimately leading to a successful and memorable sports event. It's important to note that the specific factors that need to be addressed may vary depending on the context of the sports event and the volunteers involved.
Analysis of a novel insulin lisargine at the molecular level using X-ray crystallography and biophysical techniques
Authors: Zhu Zhu , Wang Han , Wang Li , Yang Qingrong , Zhou Wei , Wang Peng , Zheng Zhiming
Published: July 2023

The structural characterization of insulin analogs is crucial for their clinical applications. In previous study, we developed a novel long-acting insulin analog called insulin lisargine, which exhibits superior sustained-release properties. However, its structure remains unclear and requires thorough investigation. We determined the amino acid sequence of insulin lisargine using mass spectrometry and analyzed its secondary structure using circular dichroism spectroscopy. Furthermore, we employed X-ray crystallography experiments at the Shanghai Synchrotron Radiation Facility to elucidate the crystal structure of the insulin lisargine analog, achieving a resolution of approximately 2.0Å. Comparison with the human insulin structure in the Protein Data Bank revealed structural similarities between the two. These findings suggest promising prospects for the insulin lisargine analog and provide essential foundational information for subsequent drug design and optimization. In summary, we conducted a comprehensive structural study on the insulin lisargine analog, shedding light on its potential applications in the field. The obtained insights pave the way for future drug development and optimization efforts.
Correlation Challenges for North-Sea Offshore Wind Power–A Norwegian Case Study
Authors: Hjelmeland Martin , Nøland Jonas Kristiansen
Published: July 2023

Offshore wind power projects are currently booming around the North Sea. However, there are inherent correlation challenges between wind farms in this area, which has implications for the optimal composition of locations and the scale-up of installed capacities. This paper is aimed at addressing the correlation problem by minimizing the variance of total wind power accumulated around the North Sea. We show that this nonlinear convex optimization problem can be solved by applying the Augmented Lagrangian optimization algorithm. The premise of the study is that more interconnections between the EU countries will be prioritized in order to optimize and smooth out the wind power production patterns. A dataset with historical hour-by-hour data spanning over 18 years was used for the analysis. We have focused on two scenarios for Norwegian offshore wind. One scenario includes the ongoing activities on the European continental side of the North Sea and the implications for Norway. Here we show the benefits of focusing on wind power buildouts in the north of Norway to increase the value of the wind power generated. Another reference scenario overlooks this impact by ignoring interconnections. Here, significantly more offshore wind will be built in the south of Norway, Sørige Nordsjø II, in particular. Our work has also estimated the wind power correlation coefficient in the North Sea as a function of the distance. Finally, the deviations and intermittencies in the North Sea wind power have been analyzed over different time intervals, highlighting that the perceived integration challenges strongly depend on the considered time resolution in the analysis.
Evaluation of Occupational Stress Among Pg Residents and Practitioners of Oral and Maxillofacial Surgery in South Kerala Population
Authors: Rajan Ravi , Varghese Geethu Philo
Published: July 2023

OBJECTIVE
The objective of our study was to assess the stress level among Post-graduate residents and practitioners of Oral and maxillofacial surgery in south Kerala population.
MATERIALS AND METHODS
Nearly 56 Oral and maxillofacial surgeons from the south Kerala population were given a self-administered questionnaire. This was composed of four sections including, demographic information, professional practice characteristics, work stress factors and response of to stress. The descriptive data were analyzed and Chi-square, t-test and F tests were used for statistical significance (P < 0.05).
RESULTS
32.3% of respondents responded. In all, 50% of them were under 30 years old, and 76.8% had work experience of less than five years. The stressors with the highest mean scores (SD) of 2.93 are those connected to dental procedures (1.46). Uncooperative patients (57.2%), an excessive or insufficient quantity of labour (60.5%), and a persistent pursuit of technical perfection (54.6%) were the most common causes of stress. Numerous symptoms of stress were seen in dentists, including physical weariness in 63% of cases and anxiousness in 57.1%.
CONCLUSION
In the south Kerala population, oral and maxillofacial surgery is a stressful profession. The primary significant elements that contributed to stress were a lack of experience, a poor income, uncooperative patients, and factors linked to dental procedures.
Lightweight PCB defect detection algorithm based on MSD-YOLO
Authors: zhou Guoao , Yu Lijuan , Su Yixin
Published: July 2023

Aiming at the problems of low accuracy and slow detection rate of existing target detection algorithms for PCB defect detection, and too many parameters of algorithm model leading to the inability to deploy on mobile terminals, a PCB defect detection algorithm based on MSD-YOLOv5 is proposed.Firstly, to ensure both detection accuracy and speed while reducing the model's size,we combine the lightweight MobileNet-v3 network with the CSPDarknet53 network.Further,the attention mechanism is introduced to highlight the important feature channels and weaken the less useful ones, so as to improve the feature extraction ability of the network. Finally, the coupling detection head is replaced with a decoupling detection head, and the defect location information and category information on the PCB are extracted and learned respectively, which solves the problem of highly coupling of different information feature distributions and enhances the generalization ability of the model.We conduct experiments on a publicly available PCB defect dataset from Peking University using this algorithm.The results show that the proposed method reduces the parameters of YOLOv5 model by 46% and improves the detection accuracy by 3.34%.
External quality assessment scheme for sperm DNA fragmentation: A pilot study in China
Authors: Zheng Yan , Wu Ying-Bi , Jia Ye-Lin , Ying Li-Juan , Yang Ting-Ting , Cheng Qing-Yuan , Qin Jiao , Luo Chen , Yu Lin , Li Fuping
Published: July 2023

Background: The aim of this article is to establish an external quality assessment(EQA) scheme for sperm DNA fragmentation(SDF) detection, and to assess the feasibility of the scheme.
Material and Methods: In 2021 and 2022, 10 and 28 laboratories in China volunteered to participate in the EQA program. The ejaculates that remained after semen analysis were mixed to provide two lots (one high and one low ), the pooled semen samples were evenly distributed into cryotubes with the volume of 500μl, which were then directly immersed in liquid nitrogen for preservation. Samples were transported to each laboratory in dry ice. Participants were asked to test EQA samples according to the laboratory’s routine procedure.
Results: A large spread of results was obtained for the four samples, and the highest values were 13.7, 4.2, 8.0 and 4.0 times the lowest, respectively. The Coefficient of variations (CVs) were very high for samples with 46.6%, 30.1%, 26.7% and 30.3%, respectively. The CVs of the samples with high SDF values were lower than those of the samples with low SDF values. There was no significant difference between the results of sperm chromatin structure assay(SCSA) and sperm chromatin dispersion(SCD). In 2021, the CVs of low value sample and high value sample of 10 participants were 46.6% and 30.1%, and the CVs decreased to 32.5% and 22.7% in 2022.
Conclusion: This is the first study to evaluate the EQA program on SDF, which involved a number of laboratories, and demonstrated to be feasible. It is recommended that all laboratories are expected to participate in the EQA of SDF to ensure the accuracy of the results.
Neoadjuvant Trastuzumab-Based Chemotherapy and Pathologic Complete Response in HER2-Positive Breast Cancer; A Systematic Review
Authors: Fazal Faizan , Khan Amina , Adil Maham Leeza , Abbas Farrukh , Bashir Muhammad Nauman
Published: July 2023

Introduction: Breast cancer is a prevalent global disease, with higher incidence in developed countries and greater mortality rates in developing countries due to disparities in screening, diagnostics, and treatment access. Classification is based on histology and molecular markers, with hormone receptor status and HER2 expression guiding treatment decisions. Trastuzumab has significantly improved outcomes for HER2-positive breast cancer. A systematic review was conducted to evaluate the effectiveness of neoadjuvant chemotherapy and Trastuzumab in achieving pathological complete response (pCR).
Methods: Nine clinical trials focusing on HER2-positive breast cancer patients undergoing neoadjuvant chemotherapy and Trastuzumab were included. Eligibility criteria encompassed non-metastatic operable, locally advanced, or inflammatory breast cancer cases with pCR as the primary or secondary endpoint. Trials employed various chemotherapy and targeted therapy regimens with different Trastuzumab dosages. The primary outcome of interest was the pCR rate, while other survival outcomes were not analyzed. Data extraction and outcome definitions followed specific criteria.
Results: Out of 3,126 initially identified studies, only nine trials met the inclusion criteria. Selected trials were described in terms of design, patient numbers, disease staging, HER2 status, administered neoadjuvant chemotherapy and Trastuzumab regimens, and primary/secondary endpoints. Among 1,209 patients receiving neoadjuvant chemotherapy and Trastuzumab, the overall pCR rate was 42%. Detailed information on pCR rates, endpoints, and trial numbers was provided, noting slight variations in the definition of pCR.
Conclusion: In conclusion, this systematic review demonstrated a 42% pCR rate with neoadjuvant chemotherapy and Trastuzumab in HER2-positive breast cancer
Seven Stage Model of the Soft System Methodology for Software Development Process
Authors: Günaydın Gökçe , Yıldırım Sevgi Özkan
Published: July 2023

Organizations always try to improve processes, optimize workflows and minimize turnover rate in order to enhance efficiency, increase productivity, reduce waste and improve performance. Process improvement is a vital component for organizations and it can be achieved through a variety of quality methods, such as, total quality management, Lean, Six Sigma and etc. Process improvement begins with complete understanding of current processes which requires data analysis, stakeholder engagement followed by an implementation with proper methods. Soft Systems Methodology (SSM) is a perfect problem-solving approach to analyze complex processes and to find suitable implementations. This paper uses SSM in software development process (SDP) within two interrelated organizations. In this research, SSM applies some problem-solving techniques, such as systems thinking, rich picture drawings, root definition and related systems construction, conceptual model creations and action planning to maintain continuous process improvement. This thesis study contains four sub-processes of SDP. These sub-processes are called Design Management, Technical Development, Testing and Training processes. Seven-staged SSM is applied to sub-processes in order to enhance system performance. Last stage of SSM, which is action taking, is presented however it is not applied yet. Apart from this, rich pictures of sub-processes are drawn, relevant systems and root definition are identified, conceptual models are created with focus group studies. Lastly, suggestions are offered regarding to real world activities and conceptual models. Results of study shows effectiveness of SSM for ill-structured problems in SDP. It emphasizes real world activities and proposes needed activities in sub-processes to overcome issues in SDP.
A Parallel Hybrid Model for Integrating Protein Adsorption Models with Deep Neural Networks
Authors: Gama Marlon de Souza Gama , Lima Fernando Arrais Romero Dias Lima , Santana Vinícius Viena Santana , Nogueira Idelfonso Bessa dos Reis Nogueira , Tavares Frederico Wanderley Tavares , Barreto Amaro Gomes Barreto Junior
Published: July 2023

A high-accuracy modeling of the mass front evolution in a fixed bed is determined by considering the equilibrium information of the components’ concentration adsorbed on the stationary phase. Thus, adsorption isotherms based on thermodynamic principles are required in the mass balance. It is challenging to include isotherms with a high level of detail due to the necessity to compile it on each instant and position, drastically increasing the computation time. Pattern identification methods may be a solution to use a high-level isotherms model quickly and efficiently. Here, we structure a Deep Neural Network aiming to train a surrogate model using the solution of a non-linear Poisson-Boltzmann equation as a data set, modified to include the ionic dispersion potential from the Lifshitz Theory. Thus, the surrogate model output is used in the mass balance model while solving the partial differential equations which describe a column mass front. This approach generates a hybrid model in a serial identification strategy. For a case study, we analyze the mass front behavior of lysozyme in a silica-packed-bed column from pH 6 to pH 10, using different salts: NaCl, NaBr, and NaI. The results indicate a low retention time for the pHs near the isoelectric points for lysozyme (pH 10.8) and silica (pH 5.7) [1]. In addition, differences in salt types allow a significant decay in retention time and an increase in mass front compressibility in the following order: I– > Br– > Cl– due to the differences in anion polarizability. The results here indicate that a link between different scales is successfully achieved using DNN.
Transcriptomic Profiling Identified Hub Genes Linking Barrett’s Esophagus and Esophageal Adenocarcinoma
Authors: Zhang Yuting , Dai Jiacheng , Wang Danke , Zhou Jiaqi , Wang Shangzi , Suo Chen , Chen Xingdong
Published: July 2023

Background Barrett’s esophagus (BE) is a common type of metaplasia and is recognized as a precursor of esophageal adenocarcinoma (EAC). However, the gene expression pattern underlying the progression of BE and EAC remains to be comprehensively explained. Herein we performed transcriptomic analyses using public microarray data (158 EAC, 51 BE, and 27 control samples).Results Differentially expressed genes that were common and unique to BE and EAC were consequently identified. Further, NFE2L3 and MCM2 showed a higher effect size in EAC than in BE; we validated their biological functions in influencing cell proliferation using CRISPR screen data. We found that the common DEGs between EAC and BE were strongly enriched for development, differentiation, and proliferation in keratinocytes. Besides, our co-expression network revealed shared and distinct gene regulation patterns in EAC and BE. Cell markers of fibroblasts were enriched in EAC/BE-shared modules, suggesting the tissue microenvironment in BE undergoes similar dysregulation as in EAC. T cells were found to be enriched in EAC-specific modules, highlighting the involvement of the immune response against tumors. Moreover, we used an independent dataset from The Cancer Genome Atlas to validate hub genes in EAC-specific modules.Conclusions To summarize, our findings provide comprehensive insights into the gene expression profile of BE and EAC and highlight the potential roles of key regulator genes and hub genes, some of which may have a potential clinical application.
A predictive model for early death in elderly colorectal cancer patients: A population-based study
Authors: Wang QI , Shen Kexin , Fei Bingyuan , Luo Hai , Li Ruiqi , Wang Zeming , Wei Mengqiang , Xie Zhongshi
Published: July 2023

Purpose The purpose of the present study was to investigate independent risk factors for early death in elderly colorectal cancer patients (ECRC) and to develop prediction model.Methods Patients diagnosed with ECRC in Surveillance, Epidemiology, and End Result datasets (SEER) between 2010 and 2015 were included in this retrospective cohort study. For external validation, a data set from the Chinese population was gathered. Logistic regression analyses were used to identify independent risk factors for early death and to establish nomograms. Internal and external validation was performed to evaluate the nomograms using the receiver operating characteristic curve (ROC), calibration curve, and decision curve analysis (DCA).Results A total of 28111 patients in the SEER cohort and 222 patients in the Chinese cohort were included. Patients from the SEER database were randomly divided into the training cohort (n = 19,679) and internal validation cohort (n = 8,432). Patients in the Chinese cohort were selected for the external validation cohort. Overall, 3579(12.73%) patients experienced early death in the SEER cohort and 31(13.96%) in the Chinese cohort. Two reliable nomograms were constructed on the basis of some significant risk factors. Internal validation and external validation of the nomograms showed high accuracy in predicting early death.Conclusion These nomograms were considered practical tool to predict the risk of early death in ECRC patients. It was no doubt that it would aid in clinical decision-making and the development of tailored treatment strategies for this group.
Building and Evaluating Prospective Scenarios for Corn-based Biorefineries
Authors: Matos Jullyana Souza , Justi Ana Clara Alves , Miranda Júlio Cesar de Carvalho
Published: July 2023

Global warming and increasing environmental pollution have become global concerns that, coupled with the scarcity of traditional forms of energy, have motivated the implementation of more sustainable production systems, such as biorefineries. This is because biorefineries are capable of integrating technologies and processes in a single facility, generating biofuels, value-added chemicals, and energy. Thus, the aim of the study was to investigate the bioproducts and emergent technologies surrounding the processing of corn into bioethanol and refined oil. A bibliometric analysis he was carried out in order to construct and evaluate prospective scenarios related to corn biorefineries. An analysis of the proposed layouts highlighted flexibility in the production process, given that one raw material could be transformed into various bioproducts. Thus, the results presented provide a bibliographic foundation for future studies on integrating residues-processes-products in corn processing. The reason for this is that the technological routes presented could be considered incremental innovations to develop a biorefinery, which takes place gradually, given that highly integrated biorefineries are highly complex.
The Challenge of Transdisciplinarity: the Subject Area "Conflict-Compromise"
Authors: Шабунина А.К.
Published: July 2023

В статье рассматриваются аспекты конструирования и реализации исследовательских трансдисциплинарных моделей применительно к проблемному полю «конфликт-компромисс». Описываемые теоретические конструкты становятся ответом на запрос о многомерном изучении отдельного явления прошлого. Автор приводит анализ этапов развития конфликта и его эволюцию в компромисс через наддисциплинарную категорию культуры. Делается вывод, что трансдисциплинарные модели как проявление метанаучной методологии строятся на основе выбора, апробирования и иерархизации традиционного инструментального набора методов с учетом феноменологической специфики объекта исследования.

The article discusses aspects of the construction and implementation and research of transdisciplinary models in relation to the problem field "conflict-compromise". The described theoretical constructions have become a response to a request for a multidimensional study of individual phenomena of the past. The author provides an analysis of the analysis of the development of the conflict and its evolution in compromise through the supra-disciplinary structure of culture. It is concluded that transdisciplinary models as a demonstration of metascientific methodology are built on the basis of the selection, testing and hierarchization of a reliable instrumental set of methods, taking into account the phenomenological specifics of the object of study.
Sussex School of Intellectual History
Authors: Горбунов А.В.
Published: July 2023

Сассекская школа – это одно из направлений современной интеллектуальной истории. Актуальность статьи обусловлена тем, что интеллектуальная история в России является востребованным методом, о чём свидетельствуют всё чаще появляющиеся статьи с ключевым словосочетанием «интеллектуальная история». В данной статье представлен аналитический обзор основных принципов данной школы и отношения к ней со стороны других исследовательских направлений. В рамках критического анализа установлен характер самоидентификации её представителей, рассмотрена история становления школы, сформулированы основные идеи и принципы методологии Школы. Показано, что в основании её подхода положен поликонтекстуальный взгляд на интеллектуальную жизнь прошлого; указывается, что историками Сассекской школы предлагается особый исследовательский подход с крайне историкоориентированным, эклектичным и междисциплинарным характером.

The article is devoted to the Sussex School that is one of the directions of modern intellectual history. The relevance of the article is due to the fact that intellectual history in Russia is a popular method, as evidenced by the increasingly appearing articles with the keyword "intellectual history". This article presents an analytical review of the basic principles of this school and the attitude towards it from other research areas. Within the framework of the critical analysis, the nature of the self-identification of its representatives is established; the history of the formation of the school is considered; the main ideas and principles of the methodology of the School are formulated. It is shown that its approach is based on a polycontextual view of the intellectual life of the past; it is pointed out that the historians of the Sussex School offer a special research approach with an extremely historically oriented, eclectic and interdisciplinary character.
Eventfulness and Mundanity in Personal Diarys: Narrative vs Mentative
Authors: Савушкин И.С.
Published: July 2023

Статья посвящена сравнительному анализу личных дневников белоэмигрантов начало 20-х годов, прошлого века, пересекающих границу России или уже находящихся за ее пределами. В качестве аналитического инструмента автор использует понятие «ментатив», которое было введено Н.В. Максимовой в ее докторской монографии. По словам Максимовой, ментатив означает мысль-рассуждение в его речевой форме. Автором статьи устанавливается следующая корреляция: дневниковая наррация прямо связана с перемещением автора в пространстве и внешней событийностью, тогда как стратегия ментатива эксплицирует отсутствие внешних событий, остановку динамики, и фиксацию ментального состояния автора. При этом, установлено, что переход нарратива к ментативу и обратно оказывается связанным с пересечением границ государств.

This article is concerned with a comparative analysis of the personal diaries of White Russian émigrés of the early 1920s who crossed the border of Russia or were already outside of it. As an analytical tool, the author uses the concept of "mentative", which N.V. Maximova introduced in her doctoral dissertation. According to Maximova, mentative means speculative thinking in a verbal form. The author of this article establishes the following correlation: diary narration is directly related to the diarist migration and current location together with external events and circumstances, whilst the strategy of mentative explicates the absence of such external events, lack of dynamics, and fixed mental state of the diarist. At the same time, it has been established that transitioning from the narrative to the mentative and vice versa is associated with crossing state borders.
New colors for the portrait of Militsa Vasilyevna Nechkina
Authors: Корзун В.П. , Сидорова Л.А.
Published: July 2023

Рассматривается эвристический потенциал новой документальной публикации творческого наследия академика М.В. Нечкиной, составленной В.Г. Бухертом. Показано, как ее переписка с историками, писателями и деятелями культуры, а также поэтическое творчество могут открывать неизвестные ранее стороны яркой и разносторонней личности выдающегося ученого и многие страницы советской исторической науки в целом.

The heuristic potential of a new documentary publication of the creative heritage of academician M.V. Nechkina, compiled by V.G. Bukhert, is considered. It is shown how her correspondence with historians, writers and cultural figures, as well as poetic creativity can reveal previously unknown sides of the bright and versatile personality of an outstanding scientist and many pages of Soviet historical science as a whole.
When They Turn Feathers to Bayonets (Review of Maciej Górny's “The Great War of the Professors”)
Authors: Пискунов М.О.
Published: July 2023

Статья является рецензией на книгу польского историка Мацея Гурного «Великая война профессоров», посвященную идеологическим столкновениям интеллектуалов враждующих сторон Первой мировой войны. Концентрируясь на восточно-европей-ских географах, физических антропологах, психологах и врачах, автор рисует широкое полотно взаимных упреков и обвинений, в которые превратилась наука враждующих стран после 1914 г. Гурный демонстрирует, как эти в научном смысле бесплодные рассуждения стали основой политической операционализации понятия раса. Истоком такого нового для Европы военного режима социально-гуманитарных наук автор видит полемику французских и немецких интеллектуалов периода 1870–1871 гг.

This article is a review of a book by Polish historian Maciej Górny, "The Great War of Professors," which deals with the ideological clashes between intellectuals on opposing sides of the First World War. Concentrating on Eastern European geographers, physical anthropologists, psychologists, and physicians, the author draws a broad canvas of mutual recriminations and accusations into which the science of the warring countries turned after 1914. Gurny demonstrates how this scientifically sterile discourse became the basis for the political operationalization of the concept of race. The author sees the origins of this new European military regime of the social and human sciences in the polemics of French and German intellectuals of the period 1870-71.
Tacitus and Russia. On the Possibilities of Historiographical Reflection
Authors: Крих С.Б.
Published: July 2023

In the article, the author gives a description and assessment of the generalizing monograph by A.P. Belikov aimed to the Roman historian Cornelius Tacitus in Russian historiography. The book is a comprehensive overview of Tacitus's translations, the main achievements in the study of his work and the most influential ideas about the views of the Roman historian on Emperor Tiberius, about imperial power in general, as well as about his narrative style. But the main theme of the article is a methodological questions, because writing such generalizing works raise problems of the relevance of old methods of the history of scholarship, which now should be discussed with particular care: about the use of “political” periodization in historiographical works, about an evaluative approach and about question how much a general historical context is needed for historiography.
Evaluation of coronal microleakage in teeth with intraorifice barriers at 2mm and 3mm: An in vitro study
Authors: Rawat Dr Ananya , Gurtu Dr Anuraag
Published: July 2023

Context:

An intraorifice barrier after endodontic therapy could remarkably mitigate the movement of bacteria and their by-products and improve the long-term prognosis of a root canal treated teeth by serving as barriers against fluid and bacterial ingress.

Aims:

The idea of the present study was to compare the coronal microleakage in teeth with 2-mm and 3mm intraorifice barriers of Bulkfill flowable composite, Glass Ionomer Cement (GIC), Cention and Biodentin under a stereomicroscope.

Methods and Material:

Eighty freshly extracted human single rooted mandibular premolars with single canal were chosen for the study. Teeth were obturated with gutta-percha using AH plus sealer. The teeth were further divided into 5 groups (16 premolars each) on the basis of intraorifice barrier material used: Bulkfill composite, GIC, Cention, Biodentin and control group. These groups were further subdivided into 2 subgroups each of 2mm and 3mm (8 teeth each) and evaluated under stereomicroscope

Statistical analysis used:

Coronal microleakage was determined under stereomicroscope using 15X magnification. Data were statistically analyzed using two-way ANOVA

Results:

According to the results, GlC at 2mm exhibited the highest micro leakage and least microleakage was shown by Biodentin at 3mm.

Conclusions:

Intraorifice barriers play a key role in reducing coronal microleakage.

Keywords:

Biodentine, Bulkfill composite, Cention, Coronal microleakage, Glass Ionomer Cement, intraorifice barrier