bluuebunny/crossref_metadata_2025 huggingface dataset:
Statistical Thermodynamics of Chiral Skyrmions in a Ferromagnetic Material
Authors: Zivieri Roberto
Published: November 2019

Solitons are a challenging topic in condensed matter physics and materials science because of the interplay between their topological and physical properties and for the crucial role they play in topological phase transitions. Among them, chiral skyrmions hosted in ferromagnetic systems are axisymmetric solitonic states attracting a lot of attention for their dazzling physical properties and technological applications. In this paper, the equilibrium statistical thermodynamics of chiral magnetic skyrmions developing in a ferromagnetic material having the shape of an ultrathin cylindrical dot is investigated. This is accomplished by determining via analytical calculations for both Néel and Bloch skyrmions: (1) the internal energy of a single chiral skyrmion; (2) the partition function; (3) the free energy; (4) the pressure; and (5) the equation of state of a skyrmion diameters population. To calculate the thermodynamic functions for points (2)–(5), the derivation of the average internal energy and of the configurational entropy is crucial. Numerical calculations of the thermodynamic functions for points (1)–(5) are applied to Néel skyrmions. These results could advance the field of materials science with special regard to low-dimensional magnetic systems.
Synthesis, Properties and Applications of Magnetic Nanoparticles and Nanowires—A Brief Introduction
Authors: Katz Evgeny
Published: November 2019

Magnetic nanoparticles and magnetic nano-species of complex topology (e.g., nanorods, nanowires, nanotubes, etc.) are overviewed briefly in the paper, mostly giving attention to the synthetic details and particle composition (e.g., core-shell structures made of different materials). Some aspects related to applications of magnetic nano-species are briefly discussed. While not being a comprehensive review, the paper offers a large collection of references, particularly useful for newcomers in the research area.
A Note on Some Identities of New Type Degenerate Bell Polynomials
Authors: Kim Taekyun , Kim Dae San , Lee Hyunseok , Kwon Jongkyum
Published: November 2019

Recently, the partially degenerate Bell polynomials and numbers, which are a degenerate version of Bell polynomials and numbers, were introduced. In this paper, we consider the new type degenerate Bell polynomials and numbers, and obtain several expressions and identities on those polynomials and numbers. In more detail, we obtain an expression involving the Stirling numbers of the second kind and the generalized falling factorial sequences, Dobinski type formulas, an expression connected with the Stirling numbers of the first and second kinds, and an expression involving the Stirling polynomials of the second kind.
On the MHD Casson Axisymmetric Marangoni Forced Convective Flow of Nanofluids
Authors: Shafiq Anum , Zari Islam , Rasool Ghulam , Tlili Iskander , Khan Tahir Saeed
Published: November 2019

The proposed investigation concerns the impact of inclined magnetohydrodynamics (MHD) in a Casson axisymmetric Marangoni forced convective flow of nanofluids. Axisymmetric Marangoni convective flow has been driven by concentration and temperature gradients due to an infinite disk. Brownian motion appears due to concentration of the nanosize metallic particles in a typical base fluid. Thermophoretic attribute and heat source are considered. The analysis of flow pattern is perceived in the presence of certain distinct fluid parameters. Using appropriate transformations, the system of Partial Differential Equations (PDEs) is reduced into non-linear Ordinary Differential Equations (ODEs). Numerical solution of this problem is achieved invoking Runge–Kutta fourth-order algorithm. To observe the effect of inclined MHD in axisymmetric Marangoni convective flow, some suitable boundary conditions are incorporated. To figure out the impact of heat/mass phenomena on flow behavior, different physical and flow parameters are addressed for velocity, concentration and temperature profiles with the aid of tables and graphs. The results indicate that Casson fluid parameter and angle of inclination of MHD are reducing factors for fluid movement; however, stronger Marangoni effect is sufficient to improve the velocity profile.
A Naso-Orbito-Ethmoid (NOE) Fracture Associated with Bilateral Anterior and Posterior Frontal Sinus Wall Fractures Caused by a Horse Kick—Case Report and Short Literature Review
Authors: Onișor-Gligor Florin , Țenț Paul Andrei , Bran Simion , Juncar Mihai
Published: November 2019

Naso-orbito-ethmoid (NOE) fractures associated with anterior and posterior frontal sinus wall fractures are among the most challenging cranio-maxillofacial injuries. These represent a major emergency, having a potentially severe clinical picture, with intracranial hemorrhage, cerebrospinal fluid (CSF) leak, meningeal lesions, pneumocephalus, contusion or laceration of the brain matter, coma, and in some cases death. In this article, we present the case of a 30-year-old patient with the diagnosis of NOE fracture associated with bilateral anterior and posterior frontal sinus wall fractures caused by a horse kick, with a fulminant post-traumatic alteration of the neurological status and major impairment of the midface bone architecture. Despite the severity and complexity of the case, early initiation of correct treatment both in terms of intensive care and cranio-maxillofacial surgery led to the successful rehabilitation of the neurological status, as well as to the reconstruction and redimensioning of midface architecture and, not least, to the restoration of the patient’s physiognomy.
Development and Characterization of an Enzyme Membrane Reactor for Fructo-Oligosaccharide Production
Authors: Burghardt Jan Philipp , Coletta Luca Antonio , van der Bolt Ramona , Ebrahimi Mehrdad , Gerlach Doreen , Czermak Peter
Published: November 2019

Fructo-oligosaccharides (FOS) are linear fructans comprising 2–5 fructose units linked to a terminal glucose residue. They are widely used as food and feed additives due to their sweetness, low calorific value, and prebiotic properties. Here we describe the synthesis of FOS catalyzed by a cell-free crude enzyme solution containing recombinant fructosyltransferase (1-FFT) produced in the yeast Kluyveromyces lactis. During the enzyme catalysis, glucose accumulates as a by-product and eventually inhibits FOS production. We therefore used an enzyme membrane reactor (EMR) to achieve the continuous removal of glucose and the simultaneous replenishment of sucrose. We observed a loss of flux during the reaction with the characteristics of complete pore blocking, probably caused by a combination of proteins (enzyme molecules) and polysaccharides (FOS). Such complex fouling mechanisms must be overcome to achieve the efficient production of FOS using EMR systems.
NK Cells from RAG- or DCLRE1C-Deficient Patients Inhibit HCMV
Authors: Wu Zeguang , Subramanian Narmadha , Jacobsen Eva-Maria , Laib Sampaio Kerstin , van der Merwe Johannes , Hönig Manfred , Mertens Thomas
Published: November 2019

The recombination-activating genes (RAGs) and the DNA cross-link repair 1C gene (DCLRE1C) encode the enzymes RAG1, RAG2 and Artemis. They are critical components of the V(D)J recombination machinery. V(D)J recombination is well known as a prerequisite for the development and antigen diversity of T and B cells. New findings suggested that RAG deficiency impacts the cellular fitness and function of murine NK cells. It is not known whether NK cells from severe combined immunodeficiency (SCID) patients with defective RAGs or DCLRE1C (RAGs−/DCLRE1C−-NK) are active against virus infections. Here, we evaluated the anti-HCMV activity of RAGs−/DCLRE1C−-NK cells. NK cells from six SCID patients were functional in inhibiting HCMV transmission between cells in vitro. We also investigated the expansion of HCMV-induced NK cell subset in the RAG- or DCLRE1C-deficient patients. A dynamic expansion of NKG2C+ NK cells in one RAG-2-deficient patient was observed post HCMV acute infection. Our study firstly reveals the antiviral activity of human RAGs−/ DCLRE1C−-NK cells.
Cracked, Porous Rocks and Fluids: Moon and Earth Paradox
Authors: Borgomano Jan V.M. , Fortin Jérôme , Guéguen Yves
Published: November 2019

Elastic wave velocities are key parameters in geosciences. In seismology at a large scale, or in seismic exploration at a more local and shallower scale, they were the main source of information for a long time. At the time of the Apollo mission, Anderson explained the unexpected result of very low velocities in Moon surface rocks by an intense cracking resulting from meteoritic impacts. Yet, it was also known that the Q factor was high. This could appear as a paradox. In the shallow layers of the Earth, rocks are porous. These shallow layers are of major importance in the Earth since they contain fluids. This is why velocities are higher and Q values lower in the Earth’s shallow layers than in the Moon’s shallow layers. Cracks have a determining effect on elastic properties because they are very compliant. Fluids also play a key role. Combining poroelasticity and effective elasticity, two independent theories much developed since the time of the Apollo mission, makes it possible to revisit the contrasting results observed in the Moon case and in the Earth case. Experimental results obtained on cracked synthetic glass show that dry cracks result in a strong decrease in velocity. On the other hand, saturated porous limestones exhibit a strong frequency-dependent attenuation when thermally cracked. The presence of fluid is the key factor.
Spanish Bentonites: A Review and New Data on Their Geology, Mineralogy, and Crystal Chemistry
Authors: García-Romero Emilia , María Manchado Eva , Suárez Mercedes , García-Rivas Javier
Published: November 2019

A review and a synthesis of the geological, mineralogical, and crystal chemical data available in the literature on active Spanish bentonitic exploitations were done, and at the same time, new data are provided from a set of representative samples from these deposits. They were located in three different areas with different geological origins: (1) Miocene sedimentary deposits from the Tajo Basin (Madrid–Toledo provinces) in the center of the Iberian Peninsula, where bentonites appear in two different units named for their colors (Green Clays and Pink Clays); (2) samples from Tamame de Sayago (Zamora province) originating from the hydrothermal alteration of granitic Variscan rocks; and 3) Miocene deposits originating from the hydrothermal alteration of volcanic or subvolcanic rocks from the Cabo de Gata volcanic area (Almería Province) in the southern part of Spain, where the three main deposits (Cortijo de Archidona, Los Trancos, and Morrón de Mateo) were studied. The bentonites from the Tajo Basin were formed mainly by trioctahedral smectites, and there were significant mineralogical differences between the Green and Pink Clays, both in terms of the contents of impurities and in terms of smectite crystallochemistry and crystallinity. The smectites from Tamame de Sayago were dioctahedral (montmorillonite–beidellite series), and they appeared with kaolinite, quartz, and mica in all possible proportions, from almost pure bentonite to kaolin. Finally, the compositions of the bentonites from the three studied deposits in Cabo de Gata were quite similar, and zeolites and plagioclases were the main impurities. The structural formulae of the smectites from Cortijo de Archidona and Los Trancos showed a continuous compositional variation in beidellite–montmorillonite, while in Morrón de Mateo, the smectites were mainly montmorillonite, although there was continuous compositional variation from Al montmorillonites to Fe–Mg-rich saponites. The variation in the smectite composition is due to the intrusion of a volcanic dome, which brings new fluids that alter the initial composition of the smectites.
Synthesis and Antibacterial Properties of Novel ZnMn2O4–Chitosan Nanocomposites
Authors: Packirisamy Rajiv Gandhi , Govindasamy Chandramohan , Sanmugam Anandhavelu , Karuppasamy K. , Kim Hyun-Seok , Vikraman Dhanasekaran
Published: November 2019

The development of productive antibacterial agents from nontoxic materials via a simple methodology has been an immense research contribution in the medicinal chemistry field. Herein, a sol–gel one-pot reaction was used to synthesize hybrid composites of hausmannite–chitosan (Mn3O4–CS) and its innovative derivative zinc manganese oxide–chitosan (ZnMn2O4–CS). Fixed amounts of CS with different metal matrix w/v ratios of 0.5%, 1.0%, 1.5%, and 2.0% for Mn and Zn precursors were used to synthesize ZnMn2O4–CS hybrid composites. X-ray diffraction analysis indicated the formation of polycrystalline tetragonal-structured ZnMn2O4 with a CS matrix in the hybrids. Fourier-transform infrared spectroscopic analysis confirmed the formation of ZnMn2O4–CS hybrids. Detailed investigations of the surface modifications were conducted using scanning electron microscopy; micrographs at different magnifications revealed that the composites’ surface changed depending on the ratio of the source materials used to synthesize the ZnMn2O4–CS hybrids. The antibacterial activity of the Mn3O4–CS and ZnMn2O4–CS composites was tested against various bacterial species, including Bacillus subtilis, Escherichia coli, Salmonella typhi, and Pseudomonas aeruginosa. The zone of inhibition and minimum inhibitory concentration values were deduced to demonstrate the efficacy of the ZnMn2O4–CS nanocomposites as antibacterial agents.
DBD Plasma Combined with Different Foam Metal Electrodes for CO2 Decomposition: Experimental Results and DFT Validations
Authors: Li Ju , Zhai Xingwu , Ma Cunhua , Zhu Shengjie , Yu Feng , Dai Bin , Ge Guixian , Yang Dezheng
Published: November 2019

In the last few years, due to the large amount of greenhouse gas emissions causing environmental issue like global warming, methods for the full consumption and utilization of greenhouse gases such as carbon dioxide (CO2) have attracted great attention. In this study, a packed-bed dielectric barrier discharge (DBD) coaxial reactor has been developed and applied to split CO2 into industrial fuel carbon monoxide (CO). Different packing materials (foam Fe, Al, and Ti) were placed into the discharge gap of the DBD reactor, and then CO2 conversion was investigated. The effects of power, flow velocity, and other discharge characteristics of CO2 conversion were studied to understand the influence of the filling catalysts on CO2 splitting. Experimental results showed that the filling of foam metals in the reactor caused changes in discharge characteristics and discharge patterns, from the original filamentary discharge to the current filamentary discharge as well as surface discharge. Compared with the maximum CO2 conversion of 21.15% and energy efficiency of 3.92% in the reaction tube without the foam metal materials, a maximum CO2 decomposition rate of 44.84%, 44.02%, and 46.61% and energy efficiency of 6.86%, 6.19%, and 8.85% were obtained in the reaction tubes packed with foam Fe, Al, and Ti, respectively. The CO2 conversion rate for reaction tubes filled with the foam metal materials was clearly enhanced compared to the non-packed tubes. It could be seen that the foam Ti had the best CO2 decomposition rate among the three foam metals. Furthermore, we used density functional theory to further verify the experimental results. The results indicated that CO2 adsorption had a lower activation energy barrier on the foam Ti surface. The theoretical calculation was consistent with the experimental results, which better explain the mechanism of CO2 decomposition.
Investigation of Pyrophosphates KYP2O7Co-Doped with Lanthanide Ions Useful for Theranostics
Authors: Watras Adam , Wujczyk Marta , Roecken Michael , Kucharczyk Katarzyna , Marycz Krzysztof , Wiglusz Rafal J.
Published: November 2019

Diphosphate compounds (KYP2O7) co-doped with Yb3+ and Er3+ ions were obtained by one step urea assisted combustion synthesis. The experimental parameters of synthesis were optimized using an experimental design approach related to co-dopants concentration and heattreatment as well as annealing time. The obtained materials were studied with theinitial requirements showing appropriate morphological (X-Ray Diffraction (XRD), Scanning Electron Microscopy (SEM)) and spectroscopic properties (emission, luminescence kinetics). Moreover, the effect of Er3+ and Yb3+ ions doped KYP2O7 on morphology, proliferative and metabolic activity and apoptosis in MC3T3-E1 osteoblast cell line and 4B12osteoclasts cell line was investigated. Furthermore, the expression of the common pro-osteogenic markers in MC3T3-E1 osteoblast as well as osteoclastogenesis related markers in 4B12 osteoclasts was evaluated. The extensive in vitro studies showed that KYP2O7 doped with 1 mol% Er3+ and 20 mol% Yb3+ ions positively affected the MC3T3-E1 and 4B12 cells activity without triggering their apoptosis. Moreover, it was shown that an activation of mTOR and Pi3k signaling pathways with 1 mol% Er3+, 20 mol% Yb3+: KYP2O7 can promote the MC3T3-E1 cells expression of late osteogenic markers including RUNX and BMP-2. The obtained data shed a promising light for KYP2O7 doped with Er3+ and Yb3+ ions as a potential factors improving bone fracture healing as well as in bioimaging (so-called in theranostics).
Developmental Vitamin D Deficiency in the Rat Impairs Recognition Memory, but Has No Effect on Social Approach or Hedonia
Authors: Overeem Kathie , Alexander Suzy , Burne Thomas H. J. , Ko Pauline , Eyles Darryl W.
Published: November 2019

Developmental vitamin D (DVD) deficiency is a risk factor for schizophrenia. In rodents we show that DVD-deficiency alters brain development and produces behavioral phenotypes in the offspring of relevance to the positive symptoms of schizophrenia. The aims of this study are to examine behavioral phenotypes specific to the cognitive and negative symptoms of schizophrenia in this model, and to vary the duration of vitamin D deficiency during gestation and beyond birth. We hypothesize that a longer duration of DVD-deficiency would result in greater behavioral impairments. Female vitamin D-deficient Sprague Dawley dams were mated at 10 weeks of age. Dietary vitamin D was reintroduced to dams and/or pups at different developmental time-points: Conception, Birth, Post-natal day (PND) 6 and PND21. Adult male and female offspring were assessed on a battery of behavioral tests, including sucrose preference, open field, novel object recognition (NOR), social approach and social novelty. We find that all windows of DVD-deficiency impaired NOR a cognitive measure that requires intact recognition memory. Sucrose consumption, social approach and social memory negative symptom-like phenotypes were unaffected by any maternal dietary manipulation. In addition, contrary to our hypothesis, we find that rats in the Conception group, that is the shortest duration of vitamin D deficiency, demonstrate increased locomotor activity, and decreased interaction time with novel objects. These findings have implications for the increasing number of studies examining the preclinical consequences of maternal vitamin D deficiency, and continue to suggest that adequate levels of maternal vitamin D are required for normal brain development.
Associations between Food Group Intake, Cognition, and Academic Achievement in Elementary Schoolchildren
Authors: Bleiweiss-Sande Rachel , Chui Kenneth , Wright Catherine , Amin Sarah , Anzman-Frasca Stephanie , Sacheck Jennifer M.
Published: November 2019

Nutrition plays an important role in proper physical and cognitive functioning. However, there is limited evidence on the relationship between overall diet, cognition, and academic success in children, particularly among low-income and diverse groups. The objective of this study was to examine the relationships between healthful versus less healthful food group intake, cognitive performance, and academic achievement in a diverse sample of schoolchildren. 868 urban schoolchildren (age 8 to 10 years) participated in the study. Intake of healthful (fruits, vegetables, unsweetened beverages) and less healthful (sweet and salty snacks, sugar-sweetened beverages) food groups was determined via a food frequency questionnaire. Digit Span and Stroop test scores were used to assess cognitive performance. Academic achievement was assessed via standardized test scores. Multiple Poisson and multiple linear regression were used to test the associations between diet and cognitive scores. Multiple ordered logistic regression was used to assess the associations between diet and academic achievement. Potential confounders (age, sex, body mass index (BMI) z-score, race/ethnicity, English language learner status, individualized education plan enrollment, physical activity, and parent education level) were tested for inclusion in all models. The sample included 868 children (56.7% girls; 33.2% non-Hispanic white, 26.2% Hispanic, 17.1% multiracial/other, 8.3% non-Hispanic black; 40.5% overweight/obese). The most frequently consumed foods were fruits and sweet snacks (1.9 and 1.6 servings per day, respectively). There were no statistically significant associations between diet and cognitive test scores. Greater intake of less healthful food groups (sweet snacks, salty snacks, and sweetened beverages) was associated with lower math (OR = 0.91, CI [0.84, 0.98], p = 0.014) and English standardized test scores (OR = 0.87, CI [0.80, 0.94, p = 0.001). Greater intake of sweet snacks and fruits was associated with lower English scores (OR = 0.72, 95% CI [0.59, 0.88] p = 0.001; and OR = 0.75, 95% CI [0.72, 0.94] p = 0.003, respectively). Consumption of less healthful food groups was associated with poorer academic achievement. Further research may shed light on unexpected associations between fruit consumption and achievement. Policies targeting multiple dietary components may positively influence child academic achievement and development.
Microbial Phenolic Metabolites: Which Molecules Actually Have an Effect on Human Health?
Authors: Marhuenda-Muñoz María , Laveriano-Santos Emily P. , Tresserra-Rimbau Anna , Lamuela-Raventós Rosa M. , Martínez-Huélamo Miriam , Vallverdú-Queralt Anna
Published: November 2019

The role of gut microbiota in human health has been investigated extensively in recent years. The association of dysbiosis, detrimental changes in the colonic population, with several health conditions has led to the development of pro-, pre- and symbiotic foods. If not absorbed in the small intestine or secreted in bile, polyphenols and other food components can reach the large intestine where they are susceptible to modification by the microbial population, resulting in molecules with potentially beneficial health effects. This review provides an overview of studies that have detected and/or quantified microbial phenolic metabolites using high-performance liquid chromatography as the separation technique, followed by detection through mass spectrometry. Both in vitro experimental studies and human clinical trials are covered. Although many of the microbial phenolic metabolites (MPM) reported in in vitro studies were identified in human samples, further research is needed to associate them with clinical health outcomes.
Exploring the Health Care Challenges and Health Care Needs of Arabic-Speaking Immigrants with Cardiovascular Disease in Australia
Authors: Abdelmessih Erini , Simpson Maree-Donna , Cox Jennifer , Guisard Yann
Published: November 2019

The Arabic-speaking immigrant group, which makes up the fourth largest language group in Australia, has a high prevalence of cardiovascular disease. The objective of this study was to explore the health care challenges and needs of Arabic-speaking immigrants with cardiovascular disease (CVD), using a comparative approach with English-speaking patients with CVD as the comparable group. Methods: Participants were recruited from community settings in Melbourne, Australia. Face-to-face semi-structured individual interviews were conducted at the recruitment sites. All interviews were audio-taped, transcribed, and coded thematically. Results: 29 participants with CVD were recruited; 15 Arabic-speaking and 14 English-speaking. Arabic-speaking immigrants, and to a lesser extent English-speaking patients with CVD may have specific health care challenges and needs. Arabic-speaking immigrants’ health care needs include: effective health care provider (HCP)-patient communication, accessible care, participation in decision-making, and empowerment. English-speaking participants viewed these needs as important for CVD management. However, only a few English-speaking participants cited these needs as unmet health care needs. Conclusion: This study suggests that Arabic-speaking immigrants with CVD may have unique needs including the need for privacy, effective HCP-patient communication that takes into account patients’ limited English proficiency, and pharmacist-physician collaboration. Therefore, there may be a need to identify a health care model that can address these patients’ health care challenges and needs. This, in turn, may improve their disease management and health outcomes.
The Yield Prediction of Synthetic Fuel Production from Pyrolysis of Plastic Waste by Levenberg–Marquardt Approach in Feedforward Neural Networks Model
Authors: Abnisa Faisal , Anuar Sharuddin Shafferina Dayana , bin Zanil Mohd Fauzi , Wan Daud Wan Mohd Ashri , Indra Mahlia Teuku Meurah
Published: November 2019

The conversion of plastic waste into fuel by pyrolysis has been recognized as a potential strategy for commercialization. The amount of plastic waste is basically different for each country which normally refers to non-recycled plastics data; consequently, the production target will also be different. This study attempted to build a model to predict fuel production from different non-recycled plastics data. The predictive model was developed via Levenberg-Marquardt approach in feed-forward neural networks model. The optimal number of hidden neurons was selected based on the lowest total of the mean square error. The proposed model was evaluated using the statistical analysis and graphical presentation for its accuracy and reliability. The results showed that the model was capable to predict product yields from pyrolysis of non-recycled plastics with high accuracy and the output values were strongly correlated with the values in literature.
Amino-Functionalized Lead Phthalocyanine-Modified Benzoxazine Resin: Curing Kinetics, Thermal, and Mechanical Properties
Authors: Zu Li-wu , Gao Bao-chang , Pan Zhong-cheng , Wang Jun , Dayo Abdul Qadeer , Liu Wen-bin
Published: November 2019

Phenol-diaminodiphenylmethane-based benzoxazine (P-ddm)/phthalocyanine copolymer was prepared by using P-ddm resin as matrix and 3,10,17,24-tetra-aminoethoxy lead phthalocyanine (APbPc) as additive. Fourier-transform infrared (FTIR), differential scanning calorimetry (DSC), dynamic mechanical analysis (DMA), and thermogravimetric analysis (TGA) were used to investigate the curing behavior, curing kinetics, dynamic mechanical properties, thermal stability, and impact strength of the prepared copolymers. The kinetic parameters for the P-ddm/APbPc blend curing processes were examined by utilizing the iso-conversional, Flynn–Wall–Ozawa, and Málek methods. The P-ddm/APbPc blends exhibit two typical curing processes, and DSC results confirmed that the blending of APbPc monomer can effectively reduce the curing temperature of P-ddm resin. The autocatalytic models also described the non-isothermal curing reaction rate well, and the appropriate kinetic parameters of the curing process were obtained. The DMA and impact strength experiments proved that the blending of APbPc monomer can significantly improve the toughness and stiffness of P-ddm resin, the highest enhancements were observed on 25 wt.% addition of APbPc, the recorded values for the storage modulus and impact strength were 1003 MPa and 3.60 kJ/m2 higher, respectively, while a decline of 24.6 °C was observed in the glass transition temperature values. TGA curves indicated that the cured copolymers also exhibit excellent thermal stabilities.
Flat Die Extruded Biocompatible Poly(Lactic Acid) (PLA)/Poly(Butylene Succinate) (PBS) Based Films
Authors: Gigante Vito , Coltelli Maria-Beatrice , Vannozzi Alessandro , Panariello Luca , Fusco Alessandra , Trombi Luisa , Donnarumma Giovanna , Danti Serena , Lazzeri Andrea
Published: November 2019

Biodegradable polymers are promising materials for films and sheets used in many widely diffused applications like packaging, personal care products and sanitary products, where the synergy of high biocompatibility and reduced environmental impact can be particularly significant. Plasticized poly(lactic acid) (PLA)/poly(butylene succinate) (PBS) blend-based films, showing high cytocompatibility and improved flexibility than pure PLA, were prepared by laboratory extrusion and their processability was controlled by the use of a few percent of a commercial melt strength enhancer, based on acrylic copolymers and micro-calcium carbonate. The melt strength enhancer was also found effective in reducing the crystallinity of the films. The process was upscaled by producing flat die extruded films in which elongation at break and tear resistance were improved than pure PLA. The in vitro biocompatibility, investigated through the contact of flat die extruded films with cells, namely, keratinocytes and mesenchymal stromal cells, resulted improved with respect to low density polyethylene (LDPE). Moreover, the PLA-based materials were able to affect immunomodulatory behavior of cells and showed a slight indirect anti-microbial effect. These properties could be exploited in several applications, where the contact with skin and body is relevant.
Thermo/pH Responsive Star and Linear Copolymers Containing a Cholic Acid-Derived Monomer, N-Isopropylacrylamide and Acrylic Acid: Synthesis and Solution Properties
Authors: Castro-Hernández Ana , Cortez-Lemus Norma Aidé
Published: November 2019

In this work three CTAs trithiocarbonate-type were synthesized—bifunctional (with PEG), trifunctional (with glycerol), and tetrafunctional (PERT)—and used in the controlled polymerization of 2-(acryloyloxy)ethyl cholate (CAE) via reversible addition-fragmentation chain transfer (RAFT) polymerization. The resulting macroCTAs containing a cholic acid-derived polymer were chain extended with N-isopropylacrylamide with or without acrylic acid. The thermosensitive and/or pH properties of these copolymers were studied in PBS solutions. The copolymers synthesized without poly(acrylic acid) (PAAc) were unstable above the transition temperature. Similar behavior was observed for the copolymer solutions containing PAAc (2% in feed) at lower values of pH showing a faster precipitation above the LCST. On the contrary, copolymer solutions containing PAAc showed great stability at higher pH values for a longer time period at 37 °C. Interestingly, the Dh of the aggregates ranged from 18 to 30 nm in all copolymers (with or without PAAc) below the transition temperature, although the topology and the block sequence in the chain were significantly different.
Assessing Muslim Higher Education and Training Institutions (METIs) and Islamic Studies Provision in Universities in Britain: An Analysis of Training Provision for Muslim Religious Leadership after 9/11
Authors: Shah Jawad
Published: November 2019

The training of Imams and Muslim religious leaders has received much interest in the post-9/11 era, resulting in a vast amount of research and publications on the topic. The present work explores this literature with the aim of analysing key debates found therein. It finds that throughout the literature there is a pervasive demand for reform of the training and education provided by Muslim higher education and training institutions (METIs) and Islamic studies programmes at universities in the shape of a synthesis of the two pedagogic models. Such demands are founded on the claim that each is lacking in the appositeness of its provision apropos of the British Muslim population. This article calls for an alternative approach to the issue, namely, that the university and the METI each be accorded independence and freedom in its pedagogic ethos and practice (or else risk losing its identity), and a combined education from both instead be promoted as a holistic training model for Muslim religious leadership.
Tail Dependence in Financial Markets: A Dynamic Copula Approach
Authors: Cortese Federico Pasquale
Published: November 2019

This article is concerned with the study of the tail correlation among equity indices by means of dynamic copula functions. The main idea is to consider the impact of the use of copula functions in the accuracy of the model’s parameters and in the computation of Value-at-Risk (VaR). Results show that copulas provide more sophisticated results in terms of the accuracy of the forecasted VaR, in particular, if they are compared with the results obtained from Dynamic Conditional Correlation (DCC) model.
Beyond Gathering the ‘Low-Hanging Fruit’ of Green Technology for Improved Environmental Performance: an Empirical Examination of the Moderating Effects of Proactive Environmental Management and Business Strategies
Authors: Forés Beatriz
Published: November 2019

This study draws on the natural resource-based view and the dynamic capabilities theory to analyse the effects of green technology, proactive environmental management and business strategy on environmental performance. This paper offers a novel analysis of the direct effect of the integrated use of green technology on environmental performance, considering a non-linear relationship between them, and how this impact can be leveraged through a formal proactive environmental planning, coordination and control system, and a defined business strategy. In order to test the research hypotheses, multiple linear regression was used on a sample of 446 Spanish tourism firms. The results confirm a non-linear relationship between green technology and environmental performance. They also indicate the importance of defining a clear, proactive environmental management and prospector strategy to achieve more efficient products/services, processes and technologies, with minimal environmental impact. This research also provides some insights into the moderating effect exerted by proactive environmental management in terms of strengthening the relationship between green technology and environmental performance. In addition, the analysis confirms that whereas defender strategies reduce the impact of green technology on environmental performance, analyser and prospector strategies enhance its influence. These results can be used to offer a series of guidelines for both private and public agents in the tourism sector.
Investigations of Laser Produced Plasmas Generated by Laser Ablation on Geomaterials. Experimental and Theoretical Aspects
Authors: Enescu Florin , Irimiciuc Stefan Andrei , Cimpoesu Nicanor , Bedelean Horea , Bulai Georgiana , Gurlui Silviu , Agop Maricel
Published: November 2019

Several surface investigation techniques, such as X-ray diffraction (XRD), EDX, and optical microscopy, were employed in order to describe the mineral contents in several geomaterials. Space and time resolved optical emission spectroscopy was implemented to analyze the plasma generated by the laser–geomaterial interaction. The values of the plasma parameters (velocity and temperature) were discussed with respect to the nature of the minerals composing the geomaterials and the morphological structure of the samples. Correlations were found between the excitation temperatures of the atomic and ionic species of the plasmas and the presence of calcite in the samples. A mathematical model was built to describe the dynamics in ablation plasma using various mathematical operational procedures: multi structuring of the ablation plasma by means of the fractal analysis and synchronizations of the ablation plasma entities through SL (2R) type group invariance and in a particular case, through self-modulation in the form of Stoler type transformations. Since Stoler type transformations are implied in general, in the charge creation and annihilation processes, then the SL (2R) type group invariance become fundamental in the description of ablation plasma dynamics.
A Computationally Efficient Joint Cell Search and Frequency Synchronization Scheme for LTE Machine-Type Communications
Authors: Jung Yong-An , Shin Dongkyoo , You Young-Hwan
Published: November 2019

The key features for future machine-type communication cellular systems facilitate low-power, low-cost, narrow-band, and wide-area systems. One of the challenging tasks to realize these requirements in machine-type communication cellular networks is a low-cost initial synchronization. To address this issue, this paper presents a reduced-complexity joint estimation of integer carrier frequency offset and cell identity for machine-type communication in the long-term evolution system. Using the conjugate property of a primary synchronization signal, joint search space of a number of hypotheses is reduced by two-thirds, facilitating low-complexity detection. The performance is assessed in terms of theoretical probability of detection failure. Simulation results confirm that the proposed estimation scheme achieves approximately the same performance as the conventional scheme with notably low complexity.
Methylmercury Epigenetics
Authors: Culbreth Megan , Aschner Michael
Published: November 2019

Methylmercury (MeHg) has conventionally been investigated for effects on nervous system development. As such, epigenetic modifications have become an attractive mechanistic target, and research on MeHg and epigenetics has rapidly expanded in the past decade. Although, these inquiries are a recent advance in the field, much has been learned in regards to MeHg-induced epigenetic modifications, particularly in the brain. In vitro and in vivo controlled exposure studies illustrate that MeHg effects microRNA (miRNA) expression, histone modifications, and DNA methylation both globally and at individual genes. Moreover, some effects are transgenerationally inherited, as organisms not directly exposed to MeHg exhibited biological and behavioral alterations. miRNA expression generally appears to be downregulated consequent to exposure. Further, global histone acetylation also seems to be reduced, persist at distinct gene promoters, and is contemporaneous with enhanced histone methylation. Moreover, global DNA methylation appears to decrease in brain-derived tissues, but not in the liver; however, selected individual genes in the brain are hypermethylated. Human epidemiological studies have also identified hypo- or hypermethylated individual genes, which correlated with MeHg exposure in distinct populations. Intriguingly, several observed epigenetic modifications can be correlated with known mechanisms of MeHg toxicity. Despite this knowledge, however, the functional consequences of these modifications are not entirely evident. Additional research will be necessary to fully comprehend MeHg-induced epigenetic modifications and the impact on the toxic response.
Molecular Characterization of a Novel Avian Influenza A (H2N9) Strain Isolated from Wild Duck in Korea in 2018
Authors: Yeo Seon-Ju , Than Duc-Duong , Park Hong-Seog , Sung Haan Woo , Park Hyun
Published: November 2019

A novel avian influenza virus (A/wild duck/Korea/K102/2018) (H2N9) was isolated from wild birds in South Korea in 2018, and phylogenetic and molecular analyses were conducted on complete gene sequences obtained by next-generation sequencing. Phylogenetic analysis indicated that the hemagglutinin (HA) and neuraminidase (NA) genes of the A/wild duck/Korea/K102/2018 (H2N9) virus belonged to the Eurasian countries, whereas other internal genes (polymerase basic protein 1 (PB1), PB2, nucleoprotein (NP), polymerase acidic protein (PA), matrix protein (M), and non-structural protein (NS)) belonged to the East Asian countries. A monobasic amino acid (PQIEPR/GLF) at the HA cleavage site, E627 in the PB2 gene, and no deletion of the stalk region in the NA gene indicated that the A/wild duck/Korea/K102/2018 (H2N9) isolate was a typical low pathogenicity avian influenza (LPAI). Nucleotide sequence similarity analysis of HA revealed that the highest homology (98.34%) is to that of A/duck/Mongolia/482/2015 (H2N3), and amino acid sequence of NA was closely related to that of A/duck/Bangladesh/8987/2010 (H10N9) (96.45%). In contrast, internal genes showed homology higher than 98% compared to those of other isolates derived from duck and wild birds of China or Japan in 2016–2018. The newly isolated A/wild duck/Korea/K102/2018 (H2N9) strain is the first reported avian influenza virus in Korea, and may have evolved from multiple genotypes in wild birds and ducks in Mongolia, China, and Japan.
HBV Reactivation in Patients Undergoing Hematopoietic Stem Cell Transplantation: A Narrative Review
Authors: Gentile Giuseppe , Antonelli Guido
Published: November 2019

HBV reactivation (HBVr) can occur due to the ability of HBV to remain latent in the liver as covalently closed circular DNA and by the capacity of HBV to alter the immune system of the infected individuals. HBVr can occur in patients undergoing hematopoietic stem cell transplantation (HSCT) with a clinical spectrum that ranges from asymptomatic infection to fulminant hepatic failure. The risk of HBVr is determined by a complex interplay between host immunity, virus factors, and immunosuppression related to HSCT. All individuals who undergo HSCT should be screened for HBV. HSCT patients positive for HBsAg and also those HBcAb-positive/HBsAg-negative are at high risk of HBV reactivation (HBVr) due to profound and prolonged immunosuppression. Antiviral prophylaxis prevents HBVr, decreases HBVr-related morbidity and mortality in patients with chronic or previous HBV. The optimal duration of antiviral prophylaxis remains to be elucidated. The vaccination of HBV-naïve recipients and their donors against HBV prior to HSCT has an important role in the prevention of acquired HBV infection. This narrative review provides a comprehensive update on the current concepts, risk factors, molecular mechanisms, prevention, and management of HBVr in HSCT.
The Capsid Protein of Hepatitis E Virus Inhibits Interferon Induction via Its N-Terminal Arginine-Rich Motif
Authors: Lin Shaoli , Yang Yonglin , Nan Yuchen , Ma Zexu , Yang Liping , Zhang Yan-Jin
Published: November 2019

Hepatitis E virus (HEV) causes predominantly acute and self-limiting hepatitis. However, in HEV-infected pregnant women, the case fatality rate because of fulminant hepatitis can be up to 30%. HEV infection is zoonotic for some genotypes. The HEV genome contains three open reading frames: ORF1 encodes the non-structural polyprotein involved in viral RNA replication; ORF2 encodes the capsid protein; ORF3 encodes a small multifunctional protein. Interferons (IFNs) play a significant role in the early stage of the host antiviral response. In this study, we discovered that the capsid protein antagonizes IFN induction. Mechanistically, the capsid protein blocked the phosphorylation of IFN regulatory factor 3 (IRF3) via interaction with the multiprotein complex consisting of mitochondrial antiviral-signaling protein (MAVS), TANK-binding kinase 1 (TBK1), and IRF3. The N-terminal domain of the capsid protein was found to be responsible for the inhibition of IRF3 activation. Further study showed that the arginine-rich-motif in the N-terminal domain is indispensable for the inhibition as mutations of any of the arginine residues abolished the blockage of IRF3 phosphorylation. These results provide further insight into HEV interference with the host innate immunity.
A Three-Feature Model to Predict Colour Change Blindness
Authors: Le Moan Steven , Pedersen Marius
Published: November 2019

Change blindness is a striking shortcoming of our visual system which is exploited in the popular ‘Spot the difference’ game, as it makes us unable to notice large visual changes happening right before our eyes. Change blindness illustrates the fact that we see much less than we think we do. In this paper, we introduce a fully automated model to predict colour change blindness in cartoon images based on image complexity, change magnitude and observer experience. Using linear regression with only three parameters, the predictions of the proposed model correlate significantly with measured detection times. We also demonstrate the efficacy of the model to classify stimuli in terms of difficulty.
Vision and Hyper-Responsiveness in Migraine
Authors: Aldrich Amelia , Hibbard Paul , Wilkins Arnold
Published: November 2019

We investigated contrast processing in relation to visual comfort from coloured light in individuals with migraine. In Experiment 1, 24 individuals who experienced migraine with aura (MA), 15 migraine without aura (MO), and 23 healthy controls, identified which of four patterns, one in each quadrant, had the greatest contrast. Although there were no significant differences between groups, contrast discrimination was superior in the visual field affected by aura in all eight participants in whom the aura was consistently lateralised. In Experiment 2, 20 participants without aura and 20 controls selected comfortable light with a chromaticity close to the daylight (Planckian) locus, whilst 20 individuals with aura chose more strongly saturated colours, mostly distant from the locus. In Experiment 3, nine participants with consistently unilateral aura undertook the contrast discrimination task wearing (a) lenses that provided a comfortable colour of light and (b) grey lenses of similar transmission. With grey lenses, seven of the nine individuals with unilateral aura showed a superior performance in the affected field, as before. With lenses providing a comfortable colour, however, the performance was relatively poor for the nine individuals with unilateral aura, but not for the 10 controls. This was the case in both visual fields. The cortical hyper-responsiveness with which migraine is associated may improve the perception of contrast. The perception is poorer (and more normal) with ophthalmic lenses having a comfortable colour.
Impact of Climate Change on Water Balance Components and Droughts in the Guajoyo River Basin (El Salvador)
Authors: Blanco-Gómez Pablo , Jimeno-Sáez Patricia , Senent-Aparicio Javier , Pérez-Sánchez Julio
Published: November 2019

This study assessed how changes in terms of temperature and precipitation might translate into changes in water availability and droughts in an area in a developing country with environmental interest. The hydrological model Soil and Water Assessment Tool (SWAT) was applied to analyze the impacts of climate change on water resources of the Guajoyo River Basin in El Salvador. El Salvador is in one of the most vulnerable regions in Latin America to the effects of climate change. The predicted future climate change by two climate change scenarios (RCP 4.5 and RCP 8.5) and five general circulation models (GCMs) were considered. A statistical analysis was performed to identify which GCM was better in terms of goodness of fit to variation in means and standard deviations of the historical series. A significant decreasing trend in precipitation and a significant increase in annual average temperatures were projected by the middle and the end of the twenty–first century. The results indicated a decreasing trend of the amount of water available and more severe droughts for future climate scenarios with respect to the base period (1975–2004). These findings will provide local water management authorities useful information in the face of climate change to help decision making.