bluuebunny/crossref_metadata_2025 huggingface dataset:
THE CORRELATION BETWEEN LANDUSE CHANGES WITH ROAD DENSITY IN URBAN FRINGE SOUTH SURAKARTA
Authors: Putri Dewangga Megaloka , Nurhadi Kuswanto , Rini Erma Fitria
Published: July 2019

From time to time the poplulation growth effect on the needs-of-lands. The growth of the city affect the changes of the sub-urban in a phisycal and activities. It arises as a result from the need-for-land that already not able to be fullfiled by the city Itself. Eventually, lands in the sub-urban transformed which previously dominated by non-built-up land  turn into built-up land. The movements from sub-urban to city also increased. The feeder roads between sub-urban and the city gets more dense. The study aims to review developments on the land use and density of roads in the period of time between 2010 Until 2016 and the correlation between land use development and density of roads. This research is using deductive method and ordinal regression analysis techniques. The datas that be used are primary data obtained through field observation and secondary data through study documents. The result shows the correlation between the land use development and density urban roads in the South urban fringe in the Surakarta city
EFEKTIVITAS PERKOTAAN GEMOLONG SEBAGAI PUSAT PELAYANAN PERMUKIMAN DI KABUPATEN SRAGEN
Authors: Sari Sri Murdiati Rin Permata , Hardiana Ana , Putri Rufia Andisetyana
Published: July 2019

The existence of dependency between residential service center with service area then resulted in the slice of service range from some service center adjacent. Urban Gemolong as a residential service center with six sub-districts as its service area (Gemolong, Miri, Sumberlawang, Plupuh, Kalijambe, Tanon), does not yet have a complete settlement service as well as the location of the big city (Solo, Porwodari, Boyolali) There is a tendency for the service area to not meet the needs of its services in urban Gemolong. The problem formulation in this research is how effectiveness of urban Gemolong as settlement service center in Sragen regency? The purpose of the study is the effectiveness of urban Gemolong as a settlement service center in Sragen regency. Research method in this research is deductive, with kind of quantitative research. Analytical techniques in this study is scoring analysis for suitability on each variable, and for assessment of its effectiveness by percentage approach. The conclusion obtained in this study is the effectiveness of urban Gemolong as a settlement service center in Sragen regency in the form of effective approach. Approaching effectively means that urban Gemolong as a settlement service center is in a near-successful position (approaching effectively) in fulfilling its role as a settlement service center in terms of goals, efficiency or affordability. Called approaching to succeed because of the three vaiabel approaches, there is an approach that states that viewed from the side of goals, urban Gemolong has been appropriate (effective from the side of the goal). From the approach of affordability and efficiency that is how the community to reach the service and how the availability of the number of facilities when compared with the population is still not appropriate (not yet effective). Urban Gemolong needs to improve the existing resettlement service especially from efficiency and affordability approach in order to fulfill its function and role as residential service center, in several ways that is the addition of the number of settlement service facilities, shifting and arranging the layout of the facilities so that the needs of facilities availability and affordability of the facilities are met
La precipitación geomorfológica como elemento clave en el modelado del paisaje mediterráneo
Authors: Sillero Medina Jose Antonio , Hueso Gonzalez Paloma , Ruiz Sinoga José Damián
Published: July 2019

El incremento de la frecuencia de la torrencialidad en ámbitos mediterráneos es una cuestión preocupante y no solo desde el punto de vista hidrogeomorfológico, sino también desde el humano, socioeconómico e infraestructural. La definición del umbral de torrencialidad es clave para determinar la peligrosidad de un territorio determinado. En este estudio ajustamos diferentes clasificaciones de torrencialidad con los problemas e impactos identificados en dos áreas mediterráneas contrastadas de la provincia de Málaga, una de ellas caracterizada por un clima mediterráneo subhúmedo (Guadalhorce), y otra por un clima mediterráneo seco-semiárido (Axarquía). A partir del análisis de los datos pluviométricos de 18 observatorios (Red SAIH), los resultados determinan una escasa recurrencia de los eventos torrenciales predefinidos (>100 mm 24 h-1; >60 mm h-1), razón por la que proponemos  el uso de un nuevo umbral de torrencialidad de menor duración, pero mucha más elevada intensidad (>10 mm 10 min-1), debido a que son muchos los episodios producidos por debajo de los umbrales anteriores, pero con consecuencias territoriales, como hemos constatado en el análisis mediático. La precipitación que se ajusta a este criterio ha sido definida como “precipitación geomorfológica” por su elevada capacidad de generar alteraciones en los componentes superficiales del territorio. Este tipo de precipitación presenta en ambos ambientes una alta recurrencia, un periodo de retorno prácticamente anual y una elevada erosividad.
Intervenciones no farmacológicas para reducir síntomas depresivos en mujeres con cáncer de mama
Authors: Coutiño-Escamilla Liliana , Piña-Pozas Maricela , Guimaraes-Borges Guilherme , Tobías-Garcés Aurelio , López-Carrillo Lizbeth
Published: July 2019

Objetivo. Describir y discutir los resultados de las in­tervenciones no farmacológicas (INF) adyuvantes en el tratamiento de los síntomas depresivos entre mujeres con cáncer de mama (CaMa). Material y métodos. Se realizó una revisión sistemática sobre INF, aplicadas a pacientes con cáncer y síntomas depresivos en siete bases de datos. La revisión se limitó del 1 de enero de 2006 al 31 de diciembre de 2017 y a los idiomas inglés, español y portugués. Los descriptores médicos empleados fueron “breast neoplasm” y “depression”. Resultados. Existen diversas INF que pueden estimular principalmente las dimensiones físicas o psicosociales. En este artículo se propone una clasificación basada en nueve estrategias terapéuticas identificadas, entre las que sobresalen el ejercicio, la psicoterapia y el yoga con meditación. Conclusiones. Con base en la evidencia dispo­nible, se concluye que la psicoterapia y yoga con meditación reducen los síntomas depresivos en pacientes con CaMa. Se requiere mayor investigación para determinar la magnitud de la reducción de los síntomas depresivos, de acuerdo con su gravedad, presencia de comorbilidades y diversidad de INF.
Effect of caudal ketamine on minimum local anesthetic concentration of ropivacaine in children: A prospective randomized trial
Authors: Wang Huai-Zhen , Wang Ling-Yu , Liang Hui-Hong , Fan Yan-Ting , Song Xing-Rong , She Ying-Jun
Published: July 2019

Background

Caudal ketamine has been shown to provide an effective and prolonged post-operative analgesia with few adverse effects. However, the effect of caudal ketamine on the efficacy of ropivacaine for intra-operative analgesia is unclear.

Methods

One hundred and sixty-nine children were randomized to five groups: Group C (caudal ropivacaine only), Group K0.25 (caudal ropivacaine plus 0.25 mg/kg ketamine), Group K0.5 (caudal ropivacaine plus 0.5 mg/kg ketamine), Group K0.75 (caudal ropivacaine plus 0.75 mg/kg ketamine), and Group K1.0 (caudal ropivacaine plus 1.0 mg/kg ketamine). The primary outcome was the minimum local anesthetic concentration (MLAC) of ropivacaine with/without ketamine for caudal block.

Results

The MLAC values of ropivacaine were 0.128% (0.028%) in the control group, 0.112% (0.021%) in Group K0.25, 0.112% (0.018%) in Group K0.5, 0.110% (0.019%) in Group K0.75, and 0.110% (0.020%) in Group K1.0. There were no significant differences among the five groups for the MLAC values (p=0.11). During the post-operative period the mean durations of analgesia were 270, 381, 430, 494, and 591 min in the control, K0.25, K0. 5, K0.75, and K1.0 groups respectively, which shown significant differences among the five groups (p<0.05).

Conclusions

Adding caudal ketamine to ropivacaine prolong the duration of post-operative analgesia; however, it does not decrease the MLAC of caudal ropivacaine for intra-operative analgesia in children.
Indications for adjuvant chemotherapy in patients with AJCC (7th ed.) stage IIa T3N0M0 and T1N2M0 gastric cancer – an east and west, multicenter study
Authors: Huang Ze-Ning , Desiderio Jacopo , Chen Qi-Yue , Zheng Chao-Hui , Li Ping , Xie Jian-Wei , Wang Jia-Bin , Lin Jian-Xian , Lu Jun , Cao Long-Long , Lin Mi , Tu Ru-Hong , Lin Ju-Li , Zheng Hua-Long , Huang Chang-Ming
Published: July 2019

Purpose

To determine the ideal indications of adjuvant chemotherapy(AC) in patients with stage IIa gastric cancer (T3N0M0 and T1N2M0) according to the 7th American Joint Committee on Cancer (AJCC) .

Method

1593 gastric cancer patients with T3N0M0 or T1N2M0 stage were identified from Surveillance, Epidemiology,and End Results(SEER) database in 1988.1-2012.12. Cox multiple regression, nomogram and decision curve was used.External validation was performed using database from Fujian Medical University Union Hospital(FJUUH)(n = 241) and Italy IMIGASTRIC center(n = 45).

Results

Cox multiple regression analysis showed that the risk factors that affected OS in Patients with AC were age > 65 years old, T1N2M0, LN dissection number ≤ 15, tumor size > 20 mm, and non-adenocarcinoma. Then a nomogram was constructed to predict 5-year OS and divided patients into a high-benefit from AC (points ≤ 188) or a low-benefit (points > 188) according to a recursive partitioning analysis.OS was significantly higher for the high-benefit patients in the SEER database and the FJUUH dataset than in the non-AC patients (Log-rank < 0.05), and there was no significant difference in OS between low-benefit patients and non-AC patients among the three centers (Log-rank = 0.154, 0.470, and 0.434, respectively). The decision curve indicated that the best clinical effect can be obtained when the threshold probability is 0-92%.

Conclusion

Regarding the controversy over whether T3N0M0 and T1N2M0 gastric cancer patients should be treated with AC, this study presents a predictive model that provides concise and accurate indications. These data show that high-benefit patients should receive AC.
Patients’ Perspectives of the Health Worker-patient Relationship in Cape Coast Metropolis, Ghana
Authors: Asamoah Kofi Tekyi , Appiah-Brempong Emmanuel , VAMPERE HASEHNI
Published: July 2019

Objective:
The importance of good interactions between health workers and patients cannot be over-emphasised. It calms troubled patients and allows them access to all pertinent information to ensure good health. However, some patients are harshly treated, compelling them to withhold sensitive and relevant information whiles others are given very little education on preventive health practices, hampering their preventive health practice. This study aimed to assess the health worker-patient relationship from the patients’ perspective and its effect on preventive health practices in the Cape Coast Metropolis, Ghana.
Results:
About 70% of patients were satisfied with how they are related to in hospital as 93.8% were allowed to express themselves freely without interruption by the doctor, though 22.7% believed they were not examined by the doctor. 53.1% of the participants were given explanations of their ailments, with 64.4% receiving information on how to prevent complications and recurrences. 70.7% left the consultation with a sense of control over personal health events. Below 50% were educated on intervention procedures, treatment regimens and side effects of their drugs. Generally, patients showed satisfaction with their interactions with health workers.
LUDICIDADE COMO FERRAMENTA DA DIDÃTICA: CONSTRUIR E PROMOVER O ENSINO E APRENDIZAGEM.
Authors: Franca Silva Gustavo Thayllon
Published: July 2019

Neste artigo foi proposto o estudo do lÃºdico, os conceitos de brincar, o papel do brinquedo no desenvolvimento da crianÃ§a, e as prÃ¡ticas da ludicidade no processo pedagÃ³gico, ainda apresentar como a ludicidade trabalha em conjunto com a didÃ¡tica objetivando um resultado de melhoramento no processo educacional, os mÃ©todos de pesquisa utilizados foram o de levantamento bibliogrÃ¡fico em diversas fontes da literatura como por exemplo livros de autores especialistas no assunto, periÃ³dicos cientÃ­ficos, revistas, jornais e demais fontes de acesso a informaÃ§Ã£o, resultando assim em uma complexa e robusta pesquisa onde serÃ£o apresentados discursÃµes acerca da importÃ¢ncia da didÃ¡tica e da ludicidade na concepÃ§Ã£o do brincar para o melhoramento dos desdobramentos da educaÃ§Ã£o da crianÃ§a e ainda mostrar que o brinquedo e a brincadeira tem papel de fundamental importÃ¢ncia neste contexto.
O SINDICATO E SEUS DELINEAMENTOS NO DIREITO DO TRABALHO
Authors: Reis JoÃ£o Emilio de Assis , Boer Leonardo Caetano
Published: July 2019

A legislaÃ§Ã£o trabalhista brasileira no que se refere ao sindicalismo Ã© fruto do desenvolvimento histÃ³rico, remontando ao Estado Novo atÃ© as atuais configuraÃ§Ãµes do direito coletivo, temos uma gama de proteÃ§Ãµes sindicais e garantias na luta sindical, nÃ£o obstante dissonÃ¢ncia com o atual estÃ¡gio do capitalismo. A estrutura sindical brasileira com suas vicissitudes e natureza jurÃ­dica singular Ã© unica, e com qual forma apresenta-se o sindicato no sistema brasileiro, seus delineamentos, virtudes e defeitos. Assim como seus princÃ­pios basilares em exame.
Double Cerclage In Cervical Insufficiency: A Single Tertiary Center Experience
Authors: Hortu Ismet , Sahin Cagdas , Ilgen Orkun , Kazandi Mert , Akdemir Ali , Ergenoglu A. Mete
Published: July 2019

Objective: The aim of this study is to compare the perinatal outcomes of double cerclage via laparoscopic plus transvaginal technique in women with a history of transvaginal cerclage failure, between women with single transvaginal cerclage.Study Design: Five women who were diagnosed with cervical insufficiency with a history of at least one vaginal cerclage failure and 10 women who were diagnosed with cervical insufficiency were included in this study. Laparoscopic cerclage was performed to all women who have a medical history of vaginal cerclage failure, before pregnancy and additional transvaginal cervical cerclage was performed during their pregnancy (Group 1). Single transvaginal cervical cerclage was performed to the 10 women who had a short cervix and/or cervical insufficiency during their pregnancy (Group 2). The number of cerclage failure, perinatal outcomes, gestational week at the time of delivery, birth weight and Apgar scores were evaluated.Results: All five women in group 1 underwent a cesarean section. None of them had chorioamnionitis or poor obstetric outcomes and all gave birth after the 34th week of pregnancy. All ten women in group 2 were evaluated. Two women gave birth vaginally at the 33rd week of pregnancy. Remaining eight cases gave birth above 34th week of pregnancy. Six of the eight cases underwent cesarean section and two of the remaining were delivered vaginally. Mean birth weight of the fetuses were 2490±265 g and 2.710 ±361 g in group1 and group 2, respectively. Mean gestational age at the time of birth in group 1 and group 2 were found 36±1.83 weeks and 35.6±1.14 weeks, respectively.Conclusion: Laparoscopic cervical cerclage during pregnancy could be a safe and effective treatment. However, sometimes it might not be enough and transvaginal cervical cerclage may be needed to strengthen cervical tension.
Evaluating occurrence of contaminants of emerging concerns in MF/RO treatment of primary effluent for water reuse – Pilot study
Authors: Farrokh Shad Mojtaba , Juby Graham J. G. , Delagah Saied , Sharbatmaleki Mohamadali
Published: July 2019

This study experimented with the novel approach of using a microfiltration (MF) and reverse osmosis (RO) treatment train to treat the effluent of a primary settling tank at the Inland Empire Utility Agency in Chino, CA. The pilot used polyvinylidene fluoride hollow-fiber MF modules as pretreatment for an RO skid, which used Hydranautics ESPA2 membranes in a two-stage configuration with a feed capacity of 6 gallon per minute (gpm). In this pilot configuration, researchers monitored the removal of 38 most prevalent contaminants of emerging concerns (CECs) through the MF/RO process. To investigate how operating the RO process at two fixed recovery rates of 55% and 80% would affect the performance of the MF/RO membranes, researchers applied different fluxes (8, 10, 12 and 14 gal/d/ft2 (gfd)) and evaluated the removal of CECs in 1-stage and 2-stage RO configurations. The occurrence of CECs in the MF influent, MF effluent, RO permeate, and RO concentrate were analyzed and studied. In the first phase (1-stage the RO process), flux of 14 gfd showed a better rejection value of inorganics (95.2%) when compared with those of other fluxes. Meanwhile, in the second phase (2-stage RO process), flux of 12 gfd showed a better rejection of inorganics (93.7%) when compared with those of other fluxes. Although concentrations of CECs slightly decreased in the RO permeate as the flux has increased, statistical analysis showed no significant differences between different fluxes in terms of CEC rejection.
Quinone-modified metal-organic frameworks MIL-101(Fe) as heterogeneous catalysts of persulfate activation for degradation of aqueous organic pollutants
Authors: Guo Huaisu , Guo Weilin , Liu Yang , Ren Xiaohua
Published: July 2019

In this work, quinone-modified metal-organic framework MIL-101(Fe)(Q-MIL-101(Fe)), as a novel heterogeneous Fenton-like catalyst, was synthesized for the activation of persulfate (PS) to remove bisphenol A (BPA). The synthetic Q-MIL-101(Fe) was characterized via X-ray diffraction, scanning electron microscope, Fourier transform infrared, electrochemical impedance spectroscopy, cyclic voltammetry and X-ray photoelectron spectroscopy. As compared to the pure MIL-101(Fe), Q-MIL-101(Fe) displayed better catalytic activity and reusability. The results manifested that the Q-MIL-101(Fe) kept quinone units, which successfully promoted the redox cycling of Fe3+/Fe2+ and enhanced the removal efficiency. In addition, the reaction factors of Q-MIL-101(Fe) were studied (e.g. pH, catalyst dosage, PS concentration and temperature), showing that the optimum conditions were [catalyst] = 0.2 g/L, [BPA] = 60 mg/L, [PS] = 4 mmol/L, pH = 6.79, temperature = 25 °C. On the basis of these findings, the probable mechanism on the heterogeneous activation of PS by Q-MIL-101(Fe) was proposed.
El fenómeno de los food trucks en la ciudad de Barranquilla, ¿éxito, fracaso o una simple moda?
Authors: Lama-Acosta Alex José , Ucros-Berrio Martha Cecilia , Silva-Guerra Harold
Published: July 2019

Hablar de los food trucks hoy en día en Barranquilla, es casi como hablar del pasado, debido a la particularidad que caracteriza a los Barranquilleros de tomar hasta la comida como algo de moda, así como a todas las cosas que giraron en torno al fenómeno de los food trucks en la ciudad. Al no poder movilizarse libremente por las calles, debido a las restricciones de ley, el negocio de los food trucks se trasladó a las plazas de comidas de food trucks, parqueaderos habilitados para vender comida, en las cuales los precios del arriendo por metro cuadrado superaba considerablemente el precio de un arriendo en un centro comercial y el cual exigía una prima de ingreso alta para ingresar; sin garantizar un número de clientes por día y sin darle a los propietarios la libertad de vender lo que ellos querían, pues si en la plaza ya había un negocio de pizza no podía haber otro de pizza.  Además, no resultaba nada fácil para personas sin experiencia y con poco capital operar en un espacio de 2x2, era un modelo que estaba destinado al fracaso.
Sunk cost effect in the decision-making process: an analysis with accounting and business administration students
Authors: Meireles Jéssica Priscila Rodrigues , Azevedo Yuri Gomes Paiva , Schwarz Lucas Allan Diniz , Gomes Hellen Bomfim
Published: July 2019

Purpose: The objective of this paper was to analyze the influence of the sunk cost effect in the decision-making process of Accounting and Business Administration undergraduate students of the Federal University of Rio Grande do Norte.
Methodology: The sample comprised 655 students, of which 347 were from the Accounting program and 308 from a Business Administration program. Data were collected through the application of structured questionnaires, based on the studies of Arkes and Blumer (1985), Rover, Wuerges, Tomazzia and Borba (2009) and Silva and Domingos (2010). After tabulation, the data were analyzed through descriptive statistics, as well as a Mann-Whitney U test to verify if there are differences between the answers of the Accounting and Business Administration students.
Results: The main results suggest that the amount of sunk cost can influence the occurrence of the sunk cost effect, and this evidence is perceived through the mean values, considering that the reduction of the amount of sunk cost is inversely proportional to the average disposition of the respondents in continue investing in the course of action. In addition, to identify that the investigated students take the sunk costs into consideration in the decision-making process, it is verified that there is no statistically significant difference between the medians of the respondents with regard to the questions that allow identifying the susceptibility to the sunk cost effect in the context of business decision-making.
Contributions of the Study: The study contributes to signal that the future professionals of Administration and Accounting are susceptible to the sunk cost effect, which can imply in a report of biased accounting information by future accountants, as well as biased decisions by future administrators. Furthermore, these results contrast previous evidence that suggests that agents from different areas of knowledge react differently to the presence of sunk costs.
An Intergenerational Information and Communications Technology Learning Project to Improve Digital Skills: User Satisfaction Evaluation
Authors: López Seguí Francesc , de San Pedro Marc , Aumatell Verges Eva , Simó Algado Salvador , Garcia Cuyàs Francesc
Published: July 2019

Background

“Digital Partners” is an intergenerational information and communications technology learning project carried out in the municipalities of Vic and Centelles (Catalonia) from April to May 2018. Within the framework of the introduction of community service as a subject in secondary education, the Centre for Health and Social Studies (University of Vic) created a training space with 38 intergenerational partners (aged 14-15 years and >65 years), with the aim of improving the senior users’ digital skills in terms of use of smartphones and tablets, thus helping reduce the digital divide in the territory.

Objective

The aim of this paper is to evaluate the satisfaction of both junior and senior participants toward the intervention and to explore its main drivers.

Methods

Participants who volunteered to participate in the study were interviewed. Quantitative and qualitative data gathered in paper-based ad hoc surveys were used to assess participants’ satisfaction.

Results

The experience shows a broad satisfaction of both junior and senior users. The project’s strengths include the format of working in couples; randomly pairing individuals by operating system; the ability to practice with the device itself; individuals’ free choice to decide what they wish to learn, develop, or practice; and the availability of voluntary practice material that facilitates communication and learning. With regard to aspects that could be improved, there is a need to review the timetabling flexibility of meetings to avoid hurrying the elderly and to extend the project’s duration, if necessary.

Conclusions

This activity can serve to create mutual learning through the use of mobile devices and generate security and motivation on the part of the seniors, thus reducing the digital divide and improving social inclusion.
Understanding End-User Perspectives of Mobile Pulmonary Rehabilitation (mPR): Cross-Sectional Survey and Interviews (Preprint)
Authors: Dobson Rosie , Herbst Pauline , Candy Sarah , Brott Tamzin , Garrett Jeffrey , Humphrey Gayl , Reeve Julie , Tawhai Merryn , Taylor Denise , Warren Jim , Whittaker Robyn
Published: July 2019

BACKGROUND

Pulmonary rehabilitation (PR) is an effective intervention for the management of people with chronic respiratory diseases, but the uptake of and adherence to PR programs is low. There is potential for mobile health (mHealth) to provide an alternative modality for the delivery of PR, overcoming many of the barriers contributing to poor attendance to current services.

OBJECTIVE

The objective of this study was to understand the needs, preferences, and priorities of end users for the development of an adaptive mobile PR (mPR) support program.

METHODS

A mixed methods (qualitative and quantitative) approach was used to assess the needs, preferences, and priorities of the end users (ie, patients with chronic respiratory disorders) and key stakeholders (ie, clinicians working with patients with chronic respiratory disorders and running PR). The formative studies included the following: (1) a survey to understand the preferences and priorities of patients for PR and how mobile technology could be used to provide PR support, (2) ethnographic semistructured interviews with patients with chronic respiratory disorders to gain perspectives on their understanding of their health and potential features that could be included in an mPR program, and (3) key informant interviews with health care providers to understand the needs, preferences, and priorities for the development of an mPR support program.

RESULTS

Across all formative studies (patient survey, n=30; patient interviews, n=8; and key stakeholder interviews, n=8), the participants were positive about the idea of an mPR program but raised concerns related to digital literacy and confidence in using technology, access to technology, and loss of social support currently gained from traditional programs. Key stakeholders highlighted the need for patient safety to be maintained and ensuring appropriate programs for different groups within the population. Finding a balance between ensuring safety and maximizing access was seen to be essential in the success of an mPR program.

CONCLUSIONS

These formative studies found high interest in mHealth-based PR intervention and detailed the potential for an mPR program to overcome current barriers to accessing traditional PR programs. Key considerations and features were identified, including the importance of technology access and digital literacy being considered in utilizing technology with this population.
DESIGN AND DEVELOPMENT OF TOPICAL HYDROGEL FORMULATION OF IRBISARTAN
Authors: SHAIKH ZEESHAN
Published: July 2019

Objective: Irbesartan is an antihypertensive with limited bioavailability. The objective of the study was to develop controlled release matrix tablets of irbisartan drug.

Methods: Tablets were prepared by wet granulation process. Result: In vitro drug release study revealed that HPMC causes initial burst release of drug hence combining HPMC sustained the action for 8 h (95.92±0.57% release). Fitting the in vitro drug release data to Korsmeyer equation indicated that diffusion along with erosion could be the mechanism for drug release. Compared to conventional tablets, the release of model drug from these HPMC matrix tablets was prolonged, leading to achieve an effective therapy with a low dosage of the drug, to reduce the frequency of medication. The pharmacological and clinical properties of irbesartan, a noncompetitive angiotensin II receptor type 1 antagonist, successfully used for more than a decade in the treatment of essential hypertension.

Results: Compatibility Studies In order to investigate the possible interactions between irbesartan and distinct polymers and/or diluents, FT-IR and DSC studies were carried out. FT-IR results proved that the drug was found to be compatible with excipients as wave numbers are almost similar for pure drug and also drug excipients mixture. In picture 1 and 2. DSC studies indicate that chosen excipients for the formulation were found to be compatible with the active ingredient as the melting endothermic peaks are in the range of 250-320 °C which is same as the melting point of irbisartan.

Conclusion: Irbesartan exerts its antihypertensive effect through an inhibitory effect on the pressure response to angiotensin II. Irbesartan 150–300 mg once daily confers a lasting effect over 24 h, and its antihypertensive efficacy is further enhanced by the coadministration of hydrochlorothiazide.
PRELIMINARY PHYTOCHEMICAL SCREENING AND IN VITRO ANTIMICROBIAL ACTIVITY OF THE LEAF EXTRACT OF THUNBERGIA COCCINEA (FAMILY-ACANTHACEAE)
Authors: SULTANA NARGIS , DAS SUMIT
Published: July 2019

Objective: To estimate the antimicrobial activity of the leaf extract of Thunbergia coccinea in association with phytochemical analysis.

Methods: The extraction of the leaves of Thunbergia coccinea was done by using a various solvent like petroleum ether, chloroform and methanol. The phytochemical constitutes are investigated by using standard methods. Antimicrobial activity of leave extract was carried out against gram positive bacteria (Staphylococcus aureus) and one gram negative bacteria (Escherichia coli). The anti-fungal activity of the plant extract was evaluated on Candida albicans. The testing was done by using disc diffusion method. The zone of inhibition was compared with standard Amikacin for anti-bacterial activity and fluconazole for anti-fungal activity.

Results: The present investigation shows the phytochemical analysis which revealed the presence of alkaloid, flavonoid, cardiac glycoside, saponin glycoside, tannin and phenolics. The antimicrobial activity of plant extract is showed significant result against all three of the test organism.

Conclusion: The present study concluded that the leaf extract of Thunbergia coccinea contain various phytochemicals and possess promising antimicrobial activity when compared with the standards.
HOME MEDICINE REVIEW ELDERLY BASED ASSESSMENT OF MEDICATION RELATED PROBLEMS IN MYSURU CITY
Authors: KUMAR JAIDEV , MAHENDRAPPA
Published: July 2019

Objective: Patients with medication-related problems will not be able to achieve the correct therapeutic endpoint which can ultimately result in further progression of disease and complications of the disease. The common risk factors of medication related problems are such as increased co morbidities, hepatic impairment, renal impairment, lack of certain biological enzymes such as glucose 6 phosphate dehydrogenase, the safety of medications that needs to be considered in specialised population such as pregnant and lactating women followed by infants, children, and elderly persons. Today in India there are lot of drug-related problems which goes unnoticed as most of the medical case sheets in hospitals are not properly screened due to lack of clinical pharmacy services which do not exist in most of the hospitals. To assess the medication-related problems among chronically ill patients.

Methods: Patients who met study criteria were enrolled in this research study, followed by the standard operating procedure of home medicine review was applied to carry out this research study. Drug-related problems of enrolled patients were evaluated by applying Hepler and Strand drug-related problem scale.

Results: The pharmacist intervention rate in this research study were found was 58%. The medication-related problems identified in this study were drug given without indication which was accountable for 32 % followed by drug duplication 5.21%, drug interactions 11% and adverse drug reactions 6.52 %.

Conclusion: This research study concludes that prevalence of drug-related problems among elderly patients was accountable for 40.49 % among Home Medicine Review in Mysore city due to more comorbidity which had resulted in more number of medications with respect to the individual medical case. Elderly patients will have lot of confusion which makes difficult to follow strict directions of medications prescribed by the concerned consultant. The situation of elderly patients can make still more miserable when no family members are living with them. Therefore in this type of situation, the role of pharmacist can play an important role in creating more awareness of medications to elderly patients.
A REVIEW ON FORMULATION AND CHARACTERIZATION OF HERBOSOME COMPLEX
Authors: CHAUDHURY IMDADUL HAQUE , DEB PULAK , DAS SUMIT
Published: July 2019

The major amount of active constituents comprises in herbal drugs with excellent bioactivity in vitro but less in vivo because of their poor lipid solubility and improper size of the molecules. This results in poor absorption and bioavailability of active constituents from the herbal extract. Herbosome technology enhances the bioavailability of herbal extracts. Herbosome act as the bridge between the novel delivery system and conventional delivery system. It is a complex of natural active ingredients and phospholipids (phosphatidylcholine, phosphatidylserine etc.) which increases absorption of herbal extract. Herbosome is the novel emerging technique applied to phytopharmaceuticals for the enhancement of bioavailability of herbal extract for medicinal applications. This article overviews about herbosome technology, recent advance, their application for various standardized herbal extracts and aims to provide complete scientific information, characterization about herbosomes as a promising drug delivery system.
PROPERTIES, PHARMACEUTICAL APPLICATION AND VARIOUS TECHNIQUE OF CHEMICAL MODIFICATION IN NATIVE STARCH: A DESCRIPTIVE REVIEW
Authors: BORDOLOI BISHAL JYOTI , KALITA BHUPEN , SHIL DIBYENDU
Published: July 2019

Starch is one important natural polymer that finds application in the formulation of dosage forms as the binder, disintegrates, diluents, gelling agent etc. Starch is drawing the attention in drug delivery as it is cheap, non-toxic, renewable, biodegradable and compatible with many other materials for industrial application. Starch has vital intrinsic properties that have made its pharmaceutical applications possible. It has also been used for a wide range of particular drug delivery applications, such as the delivery of challenging molecules and targeting to specific sites in the body. Starches are integrally unsuitable for most applications such as loss of viscosity and thickening power upon cooking and storage, retrogradation characteristics and absence of certain groups responsible for a particular function etc. So, in order to reduce its limitations and improve its applications, modification of starch is necessary. It can be modified by several ways like chemical modification, physical modification and genetic modification but the most important one is the chemical modification. This review summarizes the properties and application of native starchin conventional drug delivery systems within a world of dynamic drug production technology. It also describes the chemical modification like cross-linking, esterification, etherification and dual modification of starch.
Harm Reduction, Stigma and the Problem of Low Compassion Satisfaction
Authors: Knaak Stephanie , Christie Romie , Mercer Sue , Stuart Heather
Published: July 2019

Background and Objective

Canada is in the midst of an opioid crisis. Given the sheer magnitude of the crisis and escalating death toll, the mobilization of harm reduction interventions is an important priority. Currently, little is known about the role played by stigmatization, particularly in terms of how this may impact the endorsement and uptake of harm reduction strategies and initiatives among frontline providers.

Materials and Methods

Opening Minds, the anti-stigma initiative of the Mental Health Commission of Canada, undertook a one-and-a-half-year research project to understand the qualities, characteristics, sources, consequences, and solutions to the problem of stigmatization on the front-lines of the opioid crisis. A qualitative key informant design was selected. Participants included various first responder and health provider groups, people with lived experience of opioid or other drug use, and people in key policy or programming roles. Eight focus groups were held across Canada, and 15 one-on-one key informant interviews were completed.

Results

Analysis of focus group and key informant interviews revealed three main ways in which stigma shows up on the front lines of the opioid crisis among providers. These themes coalesced around a central main problem, that of low compassion satisfaction. Suggestions for how these concerns can be addressed were also identified.

Conclusion

The findings from this research revealed several key ways that stigma shows up in the experiences and perceptions of frontline providers and provide several promising avenues for combating stigmatization related to opioid use and harm reduction. An important avenue for future research is to develop and elaborate on the theoretical connections between the concepts of stigmatization and compassion satisfaction as a way to better understand the problem of stigmatization in helping environments.
A CONSTRUÇÃO DO HERÓI NO DESENHO ANIMADO: O PERÍODO DAS NARRATIVAS HÍBRIDAS (1980 – 2000)
Authors: Luiz Fernando Teixeira
Published: July 2019

Revela-se, nas últimas décadas do século XX, a incidência de séries animadas protagonizadas por heróis primordiais, afinados à mitologia pagã e às Novelas de Cavalaria. Nessa direção, o presente estudo ocupa-se em rastrear, a partir de uma perspectiva crítica, descritiva e historicista, as propostas veiculadas pelo cinema gráfico entre 1980 e 2000 e suas articulações com a literatura, o cinema e os quadrinhos. Não está em cogitação, assim, a análise minuciosa de uma obra, mas o delineamento de um panorama histórico que permita visualizar as perspectivas de representação de heróis tradicionais ao longo de vinte anos. Para tanto, recorre-se à crítica especializada, às teorias da narrativa e aos estudos sobre desenho animado e indústria cultural. Em linhas gerais, a pesquisa apontou para um quadro curioso, se comparado às décadas anteriores, marcado, predominantemente, pelo hibridismo. Assim, diversos estúdios lançavam mão de uma teia de signos típicos de circuitos específicos, como o universo da mitologia, o substrato medieval, a literatura arturiana, a fantasia futurista, o faroeste norte-americano e as fontes lendárias dos samurais.

Palavras-chave: Desenho animado. Literatura. Estética. Leitor. Herói.

THE CONSTRUCTION OF HEROES IN CARTOONS: THE PERIOD OF HYBRID NARRATIVES (1980 – 2000)

Abstract: The last decades of the 20th century saw the incidence of animated series featuring primordial heroes, attuned to pagan mythology and to chivalric romance. From a critical, descriptive and historical perspective, this paper aims to track the initiatives conveyed in animated movies between 1980 and 2000 and their correlation with literature, cinema and comic books. The paper offers a historical outline, which provides an overview of perspectives that traditional heroes were represented within a twenty-year time span. In order to do so, it relies on specialized criticism, narrative theory, and on studies about animation and cultural industry. Overall, it points towards an interesting scenario if compared to earlier decades, which were mostly marked by the presence of hybridity. Thus, diverse studios employed a network of signs from specific contexts, such as mythology, medievalism, Arthurian literature, science fiction, American western, and Japanese samurai epics.

Keywords: Animated Cartoon. Literature. Aesthetics. Reader. Hero.
“Enegrecendo o feminismo”: a opção descolonial e a interseccionalidade traçando outros horizontes teóricos
Authors: Bambirra Natércia Ventura , Lisboa Teresa Kleba
Published: July 2019

Os feminismos negros vêm prestando um grande serviço às epistemologias feministas e aos estudos sobre racismo. Ao tensionarem a omissão do feminismo branco em relação às pautas antirracistas, as mulheres negras expuseram a fragilidade das tendências universalistas. O convite aqui posto, inspirado numa revisão preliminar da literatura, é à imersão nas pautas, protagonismos e produção de conhecimento da e sobre as mulheres negras, a partir do lugar de fala da mulher negra. A perspectiva descolonial é utilizada nesse artigo como caminho teórico que evidencia a urgência em visibilizar e garantir o direito a voz às mulheres negras, sem desconsiderar o recorte de classes, o objetivo consiste na valorização de narrativas e subjetividades ainda subalternizadas. Nesse sentido, concluímos que a opção descolonial, racializada e generificada, oferece mais fundamentos para a análise das estruturas sociais a partir e por aqueles/as que lutam pelo direito a voz, escuta e visibilidade.
O corpo no poema e o poema e seu corpo na literatura de autoria feminina: um exemplo em Cecilia Meireles
Authors: Morelato Adrienne Kátia Savazoni
Published: July 2019

A poesia de Cecília Meireles foi considerada pela crítica tradicional uma poesia sem corpo, etérea e alienada das relações sociais e políticas, isto é, sem a presença do eu e alheia ao presente. Contudo, a análise de algumas obras e poemas de Meireles, tendo em vista a busca tanto do seu corpo autoral quanto do feminino, revelam uma poesia tecida com gestos e sons transfigurados em natureza. Ao mesmo tempo, a chamada eteriedade da poeta carioca esconde um corpo fluido, o qual as vezes precisa ser negado para se fazer presente e existente, enquanto sua tessitura poética será uma forma de resistência ao patriarcado que monopolizou a palavra escrita e falada, deixando para a mulher o silêncio como habitação. Neste artigo, a tessitura do corpo no tecido do texto será mostrada na poesia de Cecília Meireles como forma de resistência e existência significativa do que é ser mulher e poeta.
Um livro para pensar a participação das mulheres nos enredos da história no Alto Sertão da Bahia
Authors: Marques Tatyanne Gomes , Reis Sônia Maria Alves de Oliveira
Published: July 2019

A resenha analisa o livro "Mulheres, história e literatura em João Gumes: Alto sertão da Bahia, 1897-1930" de autoria de Maria Lúcia Porto Silva Nogueira. A obra é apontada como uma importante contribuição para o registro da participação das mulheres na história, principalmente, naquela construída no Alto-sertão da Bahia.
Negofeminismo: Teorizar, Praticar e Abrir o Caminho da África
Authors: Nnaemeka Obioma G.
Published: July 2019

O presente artigo irá explorar, entre outras questões, o entrelaçamento do momento colonial, das políticas de trabalho de campo, e as políticas de representação nos estudos feministas e nos estudos de desenvolvimento, revisando os processos de elaboração teórica e a construção de conhecimento em um ambiente de relações de poder desiguais e a diferença cultural. Os diferentes aspectos e métodos de engajamento feminista na África serão utilizados para propor o que eu chamo de negofeminismo (o feminismo da negociação; não ego feminismo) como um termo que nomeia os feminismos africanos. Ciente de uma prática (feminismo na África) que é tão diversa quanto o continente mesmo, proponho negofeminismo não para ocluir a diversidade, mas para argumentar que um aspecto recorrente em muitas culturas africanas pode ser usado para nomear a prática. Para além disso, por meio de uma breve discussão do início de um programa de estudos femininos na África, irei abordar questões de fronteiras disciplinares, pedagogia, e construção institucional em uma atmosfera de intensas atividades de ONGs limitadas e estruturadas por interesses de doadores, condicionalidades e políticas. Ademais, irei advogar em favor do questionamento e do reposicionamento de duas questões cruciais nos estudos feministas – posicionalidade e interseccionalidade. Por fim, vislumbro também uma mudança modulada no foco da interseccionalidade de raça, gênero, classe, etnicidade, sexualidade, religião, cultura, origem nacional, e assim por diante, de considerações ontológicas (estando lá) para imperativos funcionais (fazendo o que lá) e pretendo endereçar questões importantes de igualdade e reciprocidade na intersecção e no cruzamento de fronteira.
Midgard RPG: uma experiência de gamificação na educação
Authors: Serrano Paulo Henrique
Published: July 2019

A estruturação de uma experiência de gamificação ambientada em um universo de fantasia medieval é apresentada neste artigo. Baseando-se na perspectiva teórica de Gee (2007) e Werbach Hunter (2012) o universo ficcional e os elementos de jogo que o caracteriza foram criados. Os jogadores puderam escolher entre classes de personagens, diferentes conteúdos da disciplina, superar desafios com suas avaliações e gerenciar os seus recursos na aquisição de itens. A simplicidade e flexibilidade da gamificação aqui estruturada permite a sua utilização em outras disciplinas e contextos ficcionais.Palavras-chave: Gamificação. RPG. Experiência de ensino.
ENSINO DE FILOSOFIA E CRIAÇÕES CURRICULARES NA ESCOLA
Authors: Piol Andréa Scopel , Paiva Jair Miranda de
Published: July 2019

Este trabalho objetiva discutir a problemática do ensino de Filosofia e seus agenciamentos curriculares, na perspectiva da experiência de pensamento, em interface com as criações curriculares cotidianas. Apontamos a tensão existente entre, de um lado, a proposta salutar de uma metodologia do ensino de filosofia, dos requisitos imprescindíveis a um professor de filosofia no ensino médio e, de outro lado, o reconhecimento de que, nas escolas públicas brasileiras, professores e professoras de filosofia e de outras habilitações engendram outras práticas curriculares, considerando que, nos cotidianos escolares, no fazer-se professor pelo ensino, são produzidos currículos e invenções. Apontamos para possibilidades insuspeitas aos professores e professoras de filosofia efetivarem experiências de pensamento com seus alunos, experiências livres, transgressoras, potentes e criadoras.
A ORGANIZAÇÃO CURRICULAR E OS CICLOS DE FORMAÇÃO HUMANA NO ESTADO DE MATO GROSSO
Authors: Damasceno Kelly Katia , Ferreira Benedito De Jesus Pinheiro
Published: July 2019

Este artigo tem por objetivo analisar a maneira como a proposta curricular na rede estadual mato-grossense se vincula à política de organização do trabalho pedagógico a partir dos ciclos de formação humana. São empregadas as refêrenciais fundamentais da pedagogia histórico-crítica, isto é, toma-se como referência pedagógica fundamental o princípio da humanização como assimilação dos elementos clássicos da cultura humana. Os dados apresentados provêm da análise documental das Orientações Curriculares do Estado de Mato Grosso (OC´s) e das respostas de 31 (trinta e um) professores que responderam a um questionário aplicado em agosto de 2017, em quatro (04) escolas da rede estadual de educação, no município de Cuiabá/MT. A partir desse levantamento procurou-se analisar os aspectos conceituais relevantes da proposta curricular voltados à promoção da humanização, via ação intencional voltada à assimilação dos conhecimentos científicos, artísticos e filosóficos, efetiva forma de compromisso político que se entende que deve estar presente na escola organizada por ciclos de formação humana. A partir do estudo realizado, foi possível desvelar algumas fragilidades acerca da consistência do documento oficial de referência curricular do Estado de Mato Grosso e dos vínculos com a prática pedagógica.