bluuebunny/crossref_metadata_2025 huggingface dataset:
ICMS Ecológico: viabilidade de sua utilização a partir do passivo ambiental gerado pela FIOL
Authors: Sobral Neto Rivaldo Ribeiro , Baiardi Amilcar
Published: December 2021

O presente estudo busca avaliar o potencial do ICMS Ecológico (ICMS-E), como instrumento de política pública para os municípios afetados pela construção da Ferrovia de Integração Oeste-Leste (FIOL). Este trabalho possui caráter exploratório, de abordagem quali-quantitativa, tendo como foco um grupo de municípios baianos. Fundamenta-se na Constituição Federal, no Código Tributário Nacional, na Legislação Ambiental e nas Leis Estaduais. Com base em uma análise comparativa, visa estimar se os modelos de arrecadação do ICMS-E adotados pelos estados de Tocantins e Pernambuco se aplicam à Bahia. Investiga-se no contexto da inserção da FIOL, a interface da mesma com os recursos naturais e a destinação de todos os resíduos resultantes das intervenções. Avalia-se que a e temática é de grande relevância, visto que a proteção ambiental é uma preocupação global. Observou-se que a possível implementação do ICMS-E na Bahia poderia representar uma arrecadação superior a 255 milhões de reais, para os municípios baianos influenciados pela FIOL, entre os anos 2016 e 2020. Finalizando o artigo sugere que a implementação do ICMS-E na Bahia poderá ser uma alternativa viável para reverter o passivo ambiental gerado pela FIOL, constituindo-se mais um instrumento de proteção da biodiversidade.
Study of biodegradation of Poly(butylene adipate co-terephthalate) (PBAT) by maritime microorganisms from the Atlhantic Coast of Recife-PE (Brazil)
Authors: Barreto Lhaira Souza , Silva Erika Emanuele Gomes da , Henrique Mariana Alves , Barbosa Josiane Dantas Viana , Oliveira Sara Horácio de , Almeida Yeda Medeiros Bastos de , Vinhas Gloria Maria
Published: December 2021

Biodegradable polymers undergo a degradation process resulting from the action of microorganisms such as bacteria, fungi and algae. Poly(butylene adipate co-terephthalate) (PBAT) is considered a biodegradable synthetic polymer, even if its degradation has been confirmed under industrial composting conditions, the investigation of its degradation in the marine environment is still limited. Therefore, this work aims to study the biodegradation in the marine environment, of the biodegradable polymer (PBAT), and for that, it was submerged in a static system, using seawater from the coastal region of Pernambuco/Brazil as a fluid. The samples were studied by chemical, thermal and microbiological analyses, after 7, 14, 30, 90, 120 and 180 days of immersion. Microbiological analyzes indicated that aerobic heterotrophic bacteria (AHB), anaerobic heterotrophic bacteria (AnHB) and iron precipitating bacteria (IPB) were quantified in the system at all times at high concentrations, with the exception of Sulfate reducing bacteria (SRB), fungi and Pseudomonas that showed lower concentrations compared to other bacterial groups. Biodegradation was observed by the percentage of mass loss of approximately 2.25%. In the DSC, the expansion of melting peaks after exposure to the marine environment was noted, while the TGA did not show changes in the curve trends. The FTIR showed that no new band appeared, nor displacement, since the vibrations of the covalent bonds of the groups are present regardless of the biodegradation. Indicating that no significant microbiological degradation of PBAT was observed.
Agronomic potential of four rock powders, pure or mixed, as soil remineralizers
Authors: Cunha Gabriel Octávio de Mello , Almeida Jaime Antonio de
Published: December 2021

Detailed knowledge of chemical, petrographic and mineralogical compositions as well as the effects of applying rock powder on soil chemical properties and plant production are required for classifying these materials as soil remineralizers (SR), as according to Brazilian legislation in force. This study aimed to evaluate the potential of rock powders siltstone, tephrite and olivine melilitite, pure or mixed, on improving the fertility of a Cambisol and a Nitisol as well as the yield of soybean and barley crops grown in succession inside a greenhouse. For that purpose, these products were characterized as their granulometry, chemical, mineralogical and petrographic compositions. Based on the results, it was verified which products met the requirements for registration as SR established by the Normative Instruction Number 5 (NI5) from MAPA. Elemental chemical and grain size analyses indicated that all tested products met the NI5 requirements for their registration as SR. The mineral composition identified through petrographic analyses was confirmed by analyses performed via X-ray diffractometry techniques. Olivine melilitite rock, pure or mixed with siltstone, had the highest agronomic potential when compared to other powders, thus acknowledged as a SR. Although tephrite had little agronomic response on evaluated soils and crops, it also meets the SR requirements. Siltstone fulfilled most of NI5 criteria, except for exceeding the maximum content of free silica (quartz); therefore, it likely does not meet the requirements for its admittance as a SR.
Contribution of Wild Vegetables to meet Nutritional Demand of tribal population of
Surgana, District Nashik, Maharashtra, India
Authors: Kharat Agnes J. , Bhandare Ravindra Y.
Published: December 2021

In period of crisis, wild vegetables are used for their nutritional values as well as for getting additional food supplements. During present investigation total 44 wild vegetables and fruits were recorded from Surgana Region of Nashik District. Detailed information regarding local name, botanical name, family, habit, utilization of plant part and seasonal availability have been recorded. Most of these wild vegetables have become rare due to erratic rainfall and increasing urbanization in Surgana region. These less known and sometimes rare edible plant species can be promising source of income and nutrition for poor families. So steps are needed to be undertaken for extensive exploration and awareness about wild vegetables. Availability of wild vegetables through online shopping mode is helpful in creating awareness among common civic as well as it encourages cultivation and collection of these wild vegetables.
Momordica charantia constituents and the anti-proliferative activity against an ovarian
cancer cell-line SKOV-3
Authors: Pundir Vishal , Chandel Aditya
Published: December 2021

Momordica charantia fruits contain terpenoidal saponins, phenolic acids, minerals and amino acids, all of which are shown to confer beneficial effects on human health. This study describes a method to conduct qualitative composition analysis of bioactive compounds in the fresh juice of Momordica charantia fruits harvested locally in Jaunpur (Uttar Pradesh, India) grown under traditional farming conditions. Fruit juice extract consisting primarily of phenolic acids, showed presence of 12 compounds. Crude extract inhibited the viability of a platinum resistant ovarian cancer cell-line SKOV-3 in-vitro during 48 hours of treatment.
Screening of Azotobacter strains from rice plant rhizosphere for phosphate solubilizing
properties
Authors: Dewangan Niharika , Anwar Shirin
Published: December 2021

Azotobacter is a plant growth promoting bacteria which solubilize phosphorous and make it available for plants. In the present study the efforts have been taken to fulfill the aim to isolate, characterize and screen Azotobacter for phosphate solubilization from the rice rhizosphere of Durg district. Total 8 strains of Azotobacter were isolated from different rice fields. It was observed that all the strains were found to be phosphate solubilizing but in different quantity. RAZB6 is highest phosphate solubilizer (234.4±1mg/L) and RAZB4 shows minimum (82.09±1mg/L) quantity of phosphate solubilization. Since phosphorous is necessary for the plants proper development and it increases the growth of rice plant and make soil more fertile for other plants growth also so they must be commercialized and used more and more in the crop fields other than the agrochemicals.
Study of cestode infection in relation to the sex of the host fish, Mastacembelus armatus
Authors: Khare Reetesh Kumar
Published: December 2021

The present communication deals with the study of cestode infection in a popular freshwater fish, Mastacembelus armatus in relation to the male and female sex of the host. In this study the author calculated the maximum prevalence, mean intensity and relative density in the males of host fish.
Эффективность мероприятий реинжиниринга территории и застройки
Authors: СБОРЩИКОВ Сергей Борисович , ЖУРАВЛЕВ Павел Анатольевич
Published: December 2021

Рассмотрены вопросы выработки подхода к оценке эффективности мероприятий реинжиниринга территории и застройки. Определены результаты реализации данных мероприятий, состоящие из экономического, социального и градостроительного эффектов. Изложена процедура формирования экономического эффекта, включающая в себя этапы обоснования инвестиций, реализации реинжиниринговых мероприятий и эксплуатации. Приведена организационная схема обеспечения эффективности реинжиниринга территории и застройки. Идентифицирован показатель, который является следствием принятой рациональной организационной схемы реинжиниринга. Констатируется, что данный показатель прибыли формируется по результатам управления стоимостью, жизненным циклом и качеством. Отмечено, что достижение результативности мероприятий реинжиниринга территории и застройки осуществляется путем построения системы управления - производственно-инжинирингового центра. Представлена структура производственно-инжинирингового центра, реализующего мероприятия реинжиниринга. Подход к оценке эффективности мероприятий реинжиниринга, направленных на качественное преобразование территории и застройки, выражается в создании информационно-аналитической системы, содержащей не только данные о реализованных мероприятиях, производстве работ, оказании услуг, но и о земельных участках и объектах капитального строительства, расположенных на них.
Kinerja dan Potensi Daerah Irigasi di Kabupaten Pati
Authors: Astuti Arieyanti Dwi , Wahyudi Jatmiko , Damayanti Herna Octivia
Published: December 2021

ENGLISHThe management of irrigation networks affects agricultural productivity. Apart from agriculture, the development of local resource potential needs to do  to spur community economic development. The objectives of this research were (1) to analyze the irrigation area performance, and (2) to analyze the potential of the irrigation area in Pati Regency. This research was a descriptive study with quantitative approach held in February-September 2020 with the research location in the Gabus Irrigation Area, Cabean Irrigation Area, Sonorejo Irrigation Area, Keden Irrigation Area, Bendo Irrigation Area, and Lenggi Irrigation Area. Samples were members of the Water User Farmer Association and farmers in the research location. The research sample was taken by the purposive sampling technique. Analysis of performance uses the of the minister of public works and public housing regulation Number 12/PRT/M/2015 and evaluation of RAP (Rapid Appraisal Procedure), while for analysis of potential irrigation area it was calculated by scoring. The result of this research was a that performance in the Irrigation area of Pati Regency was poor  and it needs attention category, while the agricultural sector was still the most potential for the Irrigation area and other fields that have begun to develop was the livestock sector. INDONESIAPengelolaan jaringan irigasi sangat berpengaruh terhadap produktivitas pertanian. Kinerja dalam pengelolaan jaringan irigasi sangat penting dalam upaya meningkatkan produksi pertanian. Selain pertanian, pengembangan potensi sumber daya lokal perlu dilakukan untuk memacu pembangunan ekonomi masyarakat. Tujuan penelitian ini adalah (1) menganalisis kinerja daerah irigasi di Kabupaten Pati dan (2) menganalisis potensi daerah irigasi di Kabupaten Pati. Penelitian merupakan penelitian deskriptif dengan pendekatan kuantitatif dan dilaksanakan pada bulan Februari-September 2020. Lokasi penelitian di Daerah Irigasi (DI) Gabus Kecamatan Gabus, DI Cabean Kecamatan Winong, DI Sonorejo Kecamatan Jakenan, DI Keden Kecamatan Tambakromo, DI Bendo Kecamatan Margoyoso dan DI Lenggi Kecamatan Dukuhseti Kabupaten Pati. Sampel dalam penelitian adalah anggota Perkumpulan Petani Pemakai Air (P3A) dan petani di daerah irigasi lokasi penelitian. Teknik pengambilan sampel penelitian dilakukan secara purposive sampling. Analisis data kinerja dengan berdasarkan Permen PUPR No.12/PRT/M/2015 dan Evaluasi RAP (Rapid Appraisal Procedure), sedangkan untuk analisis potensi daerah irigasi dihitung dengan metode skoring. Hasil penelitian menunjukkan kinerja DI di Kabupaten Pati masuk kategori kinerja jelek dan perlu perhatian. Sektor pertanian masih merupakan sektor paling potensial untuk DI sedangkan sektor lain yang sudah mulai berkembang yaitu sektor peternakan.
Hubungan Status Gizi dan Status Hidrasi dengan Fungsi Memori Jangka Pendek Anak Usia Sekolah
Authors: Winarsih Biyanti Dwi , Fatmawati Yayuk , Hartini Sri
Published: December 2021

ENGLISHShort-term memory in school-age children is significant in the learning process and academic ability improvement. Adequate intake of nutrients and body fluids are needed to accelerate brain performance so that children have optimum memory function. A preliminary study on short term memory of students in SD N Gembong 2, Pati Regency showed that some students experienced a decrease in short-term memory. The objective of this study was to analyze the correlation between nutritional status and nutritional status with children's short-term memory. This study used a correlational design and involved 52 students from 4th - 6th grade in elementary school. The measurement of hydration status used urine specific gravity, while short-term memory was measured using a digit span test. Then, the Chi-Square test was applied to analyze the data. This study result showed that more than half of children had normal nutritional status, good hydration status and normal short-term memory. Furthermore, nutritional status and hydration status were associated with children's short-term memory. Parents should provide more attention to their children’s nutritional and fluid needs, by 1) the children are getting used to taking breakfast before going to school and 2) parents provide meals and drinks from home for their children. INDONESIAMemori jangka pendek pada anak usia sekolah sangat berpengaruh terhadap proses belajar dan upaya peningkatan kemampuan akademik. Asupan nutrisi dan cairan tubuh yang cukup dibutuhkan untuk meningkatkan kerja otak sehingga fungsi memori anak lebih optimal.  Data awal penelitian terkait memori jangka pendek anak di SD N Gembong 2 Pati menunjukkan sebagian anak mengalami penurunan memori jangka pendek. Tujuan penelitian ini adalah menganalisis hubungan status gizi dan status nutrisi dengan memori jangka pendek anak. Metode penelitian korelasional dengan jumlah sampel 52 responden anak kelas 4-6 SD. Pengumpulan data status gizi melalui pengukuran berat badan dan tinggi badan. Pengukuran status hidrasi menggunakan pemeriksaan berat jenis urine dan memori jangka pendek menggunakan test digit span. Analisa menggunakan chi square. Hasil penelitian  menunjukkan sebagian besar anak mempunyai status gizi normal, status hidrasi baik dan memori jangka pendek yang normal. Terdapat hubungan antara status gizi dan status hidrasi dengan memori jangka pendek anak. Orang tua sebaiknya lebih memperhatikan kebutuhan nutrisi dan cairan anak  dengan cara: 1) membiasakan sarapan sebelum berangkat sekolah; dan 2) pada saat anak ke sekolah lebih baik dibawakan bekal makanan dan minuman.
Strategi Peningkatan Kualitas Air Sungai: Studi Kasus Sungai Sani
Authors: Mailisa Evta Rina , Warsito Budi , Yulianto Bambang
Published: December 2021

ENGLISHApart from supporting irrigation systems, The Sani River has become a source of raw water for a water treatment company called PDAM Tirta Bening to provide clean water to the community. The purpose of this study was to investigate the water quality of the Sani River and formulate priority strategies for improving water quality according to the conditions of the Sani River. This research uses the descriptive-analytic method. Data were obtained from the document of Pati Regency Environmental Service, interviews, field observations, and questionnaires. To determine water quality, this study compared the test result with the water quality standards. Meanwhile, Analytic Hierarchy Process (AHP) became a tool to formulate strategic priorities. The result was TSS in the downstream, BOD, COD, and total phosphate from upstream to downstream, fecal coliform in the middle and downstream, and total coliform in the downstream conditions have exceeded water quality standard. The concentration of Dissolved Oxygen from upstream to downstream was <4 mg/L so it did not comply with the standard. The alternative strategies to improve included increasing community participation, increasing collaboration among stakeholders, supervision and law enforcement, environmental quality monitoring, and river normalization. INDONESIASungai Sani berfungsi dalam irigasi dan sumber air baku untuk PDAM Tirta Bening. Sungai ini termasuk sungai prioritas yang digunakan dalam perhitungan Indeks Kualitas Air Kabupaten Pati. Tujuan dari penelitian ini adalah untuk mengetahui kualitas air Sungai Sani dan merumuskan prioritas  strategi peningkatan kualitas air yang sesuai dengan kondisi Sungai Sani. Penelitian ini menggunakan metode deskriptif analitik. Data dalam penelitian ini diperoleh dari dokumen hasil uji Dinas Lingkungan Hidup Kabupaten Pati, hasil wawancara, observasi lapangan, dan pengisian kuesioner. Metode analisis data untuk mengetahui kualitas air adalah dengan membandingkan data hasil uji dengan baku mutu air. Dalam merumuskan prioritas strategi, menggunakan Analytic Hierarchy Process (AHP). Hasilnya adalah TSS di bagian hilir,  BOD, COD, dan total fosfat dari hulu sampai ke hilir, fecal coliform di bagian tengah dan hilir, serta total coliform di bagian hilir kondisinya telah melebihi baku mutu air kelas II. Untuk DO, dari hulu sampai  hilir konsentrasinya <4 mg/L  sehingga tidak mencapai baku mutu air kelas II. Hasil analisis alternatif strategi peningkatan kualitas air Sungai Sani sesuai urutan adalah peningkatan peran serta masyarakat, peningkatan kerja sama antar stakeholder, pengawasan dan penegakan hukum, pemantauan kualitas lingkungan, dan normalisasi sungai.
Penggunaan Salam Smart dalam Meningkatkan Kesehatan Mental dan Penerapan Protokol Kesehatan pada Kelompok Pengajian
Authors: Andayani Tri Rejeki , Wiboworini Budiyanti , Wiyono Nanang , Hidayati Farida
Published: December 2021

ENGLISHThe covid-19 pandemic that has occurred for a long time brings changes in the entire order of human life, including religion. Religious and social activities, like "pengajian" must immediately adapt to the new norms. An educational program is needed to ensure that every activity in "pengajian" group complies with the health protocols and reduces the potential for the emergence of new Covid-19 clusters. "Salam Smart" Program is a Healthy and Happy Life Strategy in the pandemic period. It is hoped to increase the implementation of health protocols and mental health of the members of this community. This study aimed to describe the contribution of “Salam Smart” Program on mental health improvement and the implementation of health protocols in the "pengajian" group. There were 29 participants to determine the effectiveness of the program. Data were collected using the Prokesmen Scale consisting of subscales i.e. the Health Protocol Scale (Reliability 0.875), and the Mental Health Scale (Rel = 0.796). The descriptive quantitative data analysis was applied and resulted that there was an increase of 2.62 in the application of health care and 3.92 in mental health. It can be concluded that the “Salam Smart” Education Program can be carried on as a strategy to live a healthy and happy life during the pandemic.  INDONESIAPandemi Covid-19 yang cukup panjang tentunya membawa perubahan pada seluruh tatanan kehidupan manusia, termasuk agama. Kegiatan keagamaan dan sosial harus segera beradaptasi dengan norma-norma baru. Untuk memastikan setiap kegiatan sesuai dengan protokol kesehatan dan mengurangi potensi munculnya klaster Covid-19 baru dari kelompok pengajian, perlu diadakan program edukasi. Melalui Program “Salam Cerdas” sebagai Strategi Hidup Sehat dan Bahagia di Masa Pandemi. Program ini diharapkan dapat meningkatkan penerapan protokol kesehatan dan kesehatan jiwa para anggota komunitas pengajian. Ada 29 peserta untuk menentukan efektivitas program. Pengumpulan data menggunakan Skala Prokesmen yang terdiri dari subskala yaitu Skala Protokol Kesehatan (Reliabilitas 0,875), dan Skala Kesehatan Jiwa (Rel = 0,796). Analisis data deskriptif kuantitatif digunakan dan hasilnya menunjukkan bahwa ada peningkatan 2,62 dalam penerapan perawatan kesehatan dan 3,92 dalam kesehatan mental. Dapat disimpulkan bahwa Program Pendidikan “Salam Cerdas” dapat dijadikan sebagai strategi untuk hidup sehat dan bahagia di masa pandemi.
Rebecca West and the Double Agent
Authors: Piette Adam
Published: December 2021

This essay will explore the figure of the double agent as it tests notions of citizenship mid-century, specifically the clash or fusion of internationalist/nationalist definitions of citizen loyalty in the construction of the traitor ‘revolutionary’ citizen. It will be look at Kaminsky in Rebecca West's 1966 historical novel The Birds Fall Down as a late rewriting of the double agent, which West had theorized through her analyses of William Joyce (‘Lord Haw-Haw’)’s wartime propaganda and Stephen Ward in the Profumo Affair of the early 1960s. West's thinking draws on Hannah Arendt's writings on the double agent in Origins of Totalitarianism. The essay will explore both the political Cold War contexts that motivated West's return to Tsarist Russia and the double agent, and the feminist light cast on treacherous intelligence operations as forms of patriarchal control over women's bodies and minds. West is shown to be revising the double agent trope of spy fiction, reimagining the mole traitor as totalitarian fanatic revealing the extremes of hostile patriarchy and of male political desire.
‘savage warnings and notations’: The Women Charting New Sensory Terrains in the Wake of Intelligence Work
Authors: Ferris Natalie
Published: December 2021

This article explores the extent to which creative work developed by a number of ex-intelligence operatives in the wake of war posited a total recalibration of sensation and the senses at midcentury. It will suggest that intelligence work, as well as the decades of discretion such work entailed, led to the estimation of a bewildering new sensory terrain. Was this a realm that could be, in the subversive potential of its sensory integration, uniquely inhabited by women artists and writers? How did they adapt to its new ‘savage warnings and notations’? 1 It is an argument informed by the considerable scholarship on the modernist and midcentury sensorium and the impact of global conflict on the mind, body, environment and human senses, but lies askant from this in its focus on those emerging from the secretive spaces of the intelligence services. The three voices central to this discussion, Elizabeth Bowen, Christine Brooke-Rose, and Prunella Clough, are rarely considered within the same critical space, and yet all three place sensory intelligibility at the centre of their aesthetic endeavours in the years immediately following their service. Is their work in the wake of war testament to an elusive new form of address or agency for women writers; a ‘wireless voice’ – as Brooke-Rose conceives of it – that is capable of setting revolutionary new terms of encounter and coherence?
Comparative Inventory Control Analysis With Economic Order Quantity (Eoq) And Just In Time Method To Minimize Inventory Costs At UD.Melati Jaya
Authors: ALMADANY KHAIRUNNISA
Published: December 2021

The research discusses how To Compare Inventory Control Analysis With Economic Order Quantity (EOQ) Method and Just In Time (JIT) Method To Minimize Inventory Costs At UD. Melati Jaya. This study discusses a comparative analysis of the Economic Order Quantity method and the Just In Time method to minimize inventory costs at UD. Jasmine jaya. The data analysis method used is descriptive qualitative method with comparative research that compares the Econimic Order Quantity (EOQ) method with the Just In Time (JIT) method to the cost efficiency at UD. Melati Jaya. The analysis results from the comparative calculation of inventory control show that the Just In Time Inventory Control method is more appropriate to be applied to Ud. Melati Jaya because the total cost of the inventory is smaller than the total cost of the inventory when using the Economic Order Quantity (EOQ) method.
The Effect of Profit Sharing Financing and Receivables towards Total Assets in Islamic Banking: Case Study in BNI Syariah
Authors: Hasan Zulfikar
Published: December 2021

The objective of my research is to observe at the relationship between receivables, profit-sharing financing to total assets at BNI Syariah Bank from 2016-2020. Total assets in BNI Syariah frequently endure fluctuations in total assets each year, whether receivables and profit-sharing financing have a significant effect on variable Y (total assets). The method that researchers run is a quantitative method using the help of SPPS software, while the variables that influence are the dependent variable receivables and profit-sharing financing. The funding channelled by BNI Syariah is essentially the same as other Islamic banks in Indonesia. Because it still uses an agreement that has long practised in the Islamic banking system, such as the Murabaha contract for the provision of receivables, Mudharabah and Musyarakah contracts for profit sharing between customers and banks. The relationship between Receivables and Revenue Sharing Financing has a positive correlation between variables. This research can also provide some connection between Murabahah and Musharaka which are one of the main product sources of BNI Syariah bank. The originality of the research that the researcher makes is his own, it is not copied and that the researcher's research idea is new and can add new knowledge.
Climate change action and COP
Authors: Ugle Pimpalkhute Dr. Prachi
Published: December 2021

As Climate Change has become the focal point of discussion across all sectors, entities and cities, mainstreaming it with country’s agenda be it in the parliament or via varied reporting conundrum is on all time high this decade. As leadership forays, be it as a key chair, leader, negotiator, observer, moderator, panelist, scientist, peer group or as an institutional representee – how country’s spearheads or leads the negotiations and table in the discussion for better facilitation and pathway depends on its strong legislative backing. There are varied framework, methodologies and articles available as per IPCC, UNFCCC and other global compacts (GHG inventory) on the basis of which quantification and emission reductions and its trajectories are framed; however, every country’s sectoral emission differs and so does the standardization.
A percepção do psicólogo sobre o uso da equoterapia nos portadores do transtorno do espectro autista
Authors: Fernandes Aline Larrissa Trombini , Casagrande Ediely Ferreira , Zampar Jackeline Baraldo , Meira Lucyanne de Souz , Oliveira Leonardo Pestillo de , Souza Paula Farineli de , Garcia Lucas França , Shiozaki Marcos Paulo
Published: December 2021

Este artigo descritivo com abordagem qualitativa tem como objetivo conhecer as características das crianças portadoras do Transtorno do Espectro Autista (TEA), compreender a prática equoterápica, relacionar a equoterapia com o TEA e identificar a percepção de psicólogos sobre a importância da equoterapia no tratamento do autismo. Primeiramente realizou-se uma pesquisa bibliográfica para conhecer as características e os sintomas do autismo em geral, a identificação pelos pais, e o modo geral como acontece a prática equoterápica em crianças. A pesquisa de campo foi composta por uma entrevista semiestruturada aplicada em duas psicólogas e foi realizada uma análise de conteúdo das respostas, o que possibilitou verificar a percepção que os psicólogos têm sobre os benefícios trazidos pela prática da equoterapia em crianças portadoras do TEA. A prática equoterápica foi descrita como um importante recurso que contribui para o desenvolvimento de crianças com TEA. Além da melhora do equilíbrio, da coordenação motora, consciência corporal, da respiração e das capacidades cardiovasculares, enfatizou-se também o aspecto afetivo e emocional do praticante, auto estima e potencializador da confiança do praticante.
Discovery of Mycothiogranaticins from Streptomyces vietnamensis GIMV4.0001 and the Regulatory Effect of Mycothiol on the Granaticin Biosynthesis
Authors: Deng Ming-Rong , Li Yan , Luo Xiao , Zheng Xiang-Ling , Chen Yuchan , Zhang Yu-Lian , Zhang Weimin , Zhou Hao , Zhu Honghui
Published: December 2021

Granaticins are benzoisochromanequinone polyketides with remarkable antibacterial and anticancer activities. Three sulfur-containing granaticin congeners, mycothiogranaticins A (1), B (2) and granaticin MA (3) were discovered from a granaticin-producing strain of Streptomyces vietnamensis GIMV4.0001. Two of them were structurally determined with mycothiol or N-acetylcysteine moieties and found to be bio-actively reluctant. Disruption of the mshA gene (SVTN_RS20640) that encodes the D-inositol-3-phosphate glycosyltransferase crucial for mycothiol biosynthesis, fully abolished the production of mycothiogranaticins. The result substantiated that the newly discovered mycothiogranaticins are consequences of the combination of the granaticin and mycothiol biosynthetic pathways. The overall granaticin production of the ΔmshA mutant strain was unexpectedly decreased by at least more than 50%, while similar production level of granaticins to that of the wild type strain was observed in an mycothiol-S transferase gene (SVTN_RS22215) disruptant Δmst. These results indicated that the mycothiol deficiency was responsible for the decreased production of granaticins. Mycothiol may positively regulate the biosynthesis of granaticin possibly by maintaining the cellular redox balance. To the best of our knowledge, this is the first report that mycothiol can not only be a direct building block of polyketides but also play a regulatory role in the polyketide biosynthesis.
Delivery Mode Shapes the Composition of the Lower Airways Microbiota in Newborns
Authors: Cardelli Elisa , Calvigioni Marco , Vecchione Alessandra , Macera Lisa , Mazzantini Diletta , Celandroni Francesco , Panattoni Adelaide , Pistello Mauro , Maggi Fabrizio , Ghelardi Emilia , Mannella Paolo
Published: December 2021

Radical alterations in the human microbiota composition are well-known to be associated with many pathological conditions. If these aberrations are established at the time of birth, the risk of developing correlated pathologies throughout life is significantly increased. For this reason, all newborns should begin their lives with a proper microbiota in each body district. The present study aimed at demonstrating a correlation between the mode of delivery and the development of a well-balanced microbiota in the lower airways of newborns. 44 pregnant women were enrolled in this study. Microbiological comparative analysis was carried out on tracheobronchial secretions of babies born through vaginal delivery (VD) or caesarean section (CS). All samples showed the presence of bacterial DNA, regardless of the mode of delivery. No viable cultivable bacteria were isolated from the CS samples. On the contrary, VD allowed colonization of the lower airways by alive cultivable bacteria. The identification of bacterial species revealed that Lactobacillus spp. and Bacteroides vulgatus were the most common microorganisms in the lower airways of vaginally-delivered newborns. Data obtained from quantitative PCRs showed a significantly higher total bacterial load, as well as Firmicutes and Lactobacillus spp. amount, in VD samples than CS ones, while no statistically significant difference was found in Torque Teno Virus (TTV) load between samples. Taken together, our findings confirm the hypothesis that passage through the maternal vaginal canal determines more beneficial colonization of the lower airways in newborns.
Assessing the Believability of Computer Players in Video Games: A New Protocol and Computer Tool
Authors: Even Cindy , Bosser Anne-Gwenn , Buche Cédric
Published: December 2021

In this paper, we address the challenge of believability in multiplayer video games. Our contribution is a system for assessing the believability of computer players. The state of the art examines existing methods and identifies seven distinguishing features that differ considerably from one assessment to the next. Our investigation reveals that assessment procedures typically alter gameplay, posing a considerable danger of bias. This is a major flaw since computer players are evaluated in a specific context rather than in the context of the game as it should be played, potentially skewing the findings of the evaluation. As a result, we begin on a trial-and-error process, with each new proposal building on the achievements of the previous one while removing the flaws. New proposals are tested with new assessments, a total of three experiments are then presented. We created a computer program that partially automates the execution of the assessment procedure, making these trials easier to implement. At the end, thanks to our proposal, gamers can assess the believability of computer players indirectly by employing reporting forms that alert users to the presence of bots. We assume that the more a bot is reported, the less credible it becomes. We ran a final experiment to test our proposal, which yielded extremely encouraging results.
Aortic Dissection Auxiliary Diagnosis Model and Applied Research Based on Ensemble Learning
Authors: Luo Jingmin , Zhang Wei , Tan Shiyang , Liu Lijue , Bai Yongping , Zhang Guogang
Published: December 2021

Aortic dissection (AD), a dangerous disease threatening to human beings, has a hidden onset and rapid progression and has few effective methods in its early diagnosis. At present, although CT angiography acts as the gold standard on AD diagnosis, it is so expensive and time-consuming that it can hardly offer practical help to patients. Meanwhile, the artificial intelligence technology may provide a cheap but effective approach to building an auxiliary diagnosis model for improving the early AD diagnosis rate by taking advantage of the data of the general conditions of AD patients, such as the data about the basic inspection information. Therefore, this study proposes to hybrid five types of machine learning operators into an integrated diagnosis model, as an auxiliary diagnostic approach, to cooperate with the AD-clinical analysis. To improve the diagnose accuracy, the participating rate of each operator in the proposed model may adjust adaptively according to the result of the data learning. After a set of experimental evaluations, the proposed model, acting as the preliminary AD-discriminant, has reached an accuracy of over 80%, which provides a promising instance for medical colleagues.
Sintilimab-Induced Myocarditis Overlapping Myositis in a Patient With Metastatic Thymoma: A Case Report
Authors: Yang Zi-xuan , Chen Xuan , Tang Si-qi , Zhang Qing
Published: December 2021

Although immune checkpoint inhibitor (ICI)-related myocarditis has been widely discussed, a lot of gaps and challenges in its clinical course and rational intervention remain elusive. We present the case of a 33-year-old man with a history of metastatic thymoma who developed dyspnea and muscle weakness 1 month after the first dose of sintilimab. He was asymptomatic but found to have a mild elevation of troponin-T and a moderate increase of creatine kinase 20 days after the infusion. Although the scheduled second dose was deferred, he developed dyspnea, left bundle branch block, and left ventricular enlargement that is suggestive of Grade 3 ICI-related myocarditis, complicated with myositis/myasthenia gravis 10 days later. Fortunately, his response to intensive immunosuppressive therapy was good.
Genetic Clues on Implantable Cardioverter-Defibrillator Placement in Young-Age Hypertrophic Cardiomyopathy: A Case Report of Novel MYH7 Mutation and Literature Review
Authors: Li Xing , Tang Jie , Li Jinhui , Lin Sha , Wang Tao , Zhou Kaiyu , Li Yifei , Hua Yimin
Published: December 2021

Background: Hypertrophic cardiomyopathy (HCM) is the second most common cardiomyopathy in childhood with a life-threatening risk. Implantable cardioverter-defibrillator (ICD) placement is recommended for early prevention if there are two or more clinical risk factors. Pediatric patients with HCM are at a higher risk of sudden cardiac death (SCD), but there are limited reports on indications for ICD implantation in children. Herein we describe the case of Myh7 mutation-induced HCM and cardiac arrest in a patient and evaluated information originating from genetic background to guide ICD administration.

Case Presentation: The patient was a girl aged 7 years and 8 months who had been diagnosed with cardiomyopathy in utero 8 years prior. She had had recurrent cardiac arrests within the last 4 years. Electrocardiography indicated abnormalities in conduction, and ST segment changes. Echocardiography indicated significant left ventricular hypertrophy and hypertrophic systolic interventricular septum. Cardiac magnetic resonance imaging depicted general heart enlargement with hypertrophy, and delayed enhancement in myocardium with perfusion defect was also evident. Whole exon sequencing identified a de novo c.2723T>C (p.L908P) heterozygous mutation in the MYH7 gene. MYH7 p.L908P predicted unstable protein structure and impaired function. The patient was scheduled for ICD implantation. There were no complications after ICD implantation, and she was discharged from hospital on the 10th day. Regular oral beta-blockers, amiodarone, spironolactone, and enalapril were administered, and she was required to attend hospital regularly for follow-up. During follow-up there were no cardiac arrests. Literature review of clinical prognoses associated with genetic mutations of MYH7, MYBPC3, TNNI3, TNNT2, and TPM1 in pediatric HCM patients with and without ICD implantation indicated that they were totally differently. Previous reports also indicated that gene mutations predicted earlier onset of cardiac hypertrophy, and increase likelihood of SCD.

Conclusion: Variant burden and variant type contribute to the risk of adverse events in pediatric HCM. Early recognition and intervention are vital in children. Gene mutation could be considered an indication for early ICD placement during standard risk stratification of HCM patients. Whether this extends to the majority of pediatric patients requires further investigation.
Evaluation of Various DEMs for Quantifying Soil Erosion Under Changing Land Use and Land Cover in the Himalaya
Authors: Romshoo Shakil Ahmad , Yousuf Aazim , Altaf Sadaff , Amin Muzamil
Published: December 2021

Soil erosion is one of the serious environmental threats in the Himalayas, primarily exacerbated by the steep slopes, active tectonics, deforestation, and land system changes. The Revised Universal Soil Loss Equation was employed to quantify soil erosion from the Vishav watershed in the Kashmir Himalaya, India. Topography and land use/land cover (LULC) are important driving factors for soil erosion. Most often, a Digital Elevation Model (DEM) is used in erosion models without any evaluation and testing which sometimes leads to erroneous estimates of soil erosion. For the best topographic characterization of the watershed, four publicly available DEMs with almost identical resolution (∼30 m), were evaluated. The DEMs were compared with GPS measurements to determine the most reliable among the tested DEMs for soil erosion estimation. Statistical evaluation of the DEMs with GPS data indicated that the CARTO DEM is better with root mean square error (RMSE) of 18.2 m than the other three tested DEMs viz., Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER), Shuttle Radar Topography Mission (SRTM), and Advanced Land Observing Satellite (ALOS). Slope length and slope steepness factors were computed from the DEMs. Crop cover and management factors were generated from the satellite-derived LULC. Moreover, rainfall data of the nearest stations were used to compute rainfall erosivity and soil erodibility factor was derived from the soil texture data generated from 375 soil samples. The simulated erosion estimates from SRTM, ALOS, and CARTO DEMs showed similar spatial patterns contrary to the ASTER estimates which showed somewhat different patterns and magnitude. The mean erosion in the study area has almost doubled from 2.3 × 106 tons in 1981 to 4.6 × 106 tons in 2019 mainly driven by the anthropogenic LULC changes. The increased soil erosion is due to the degradation of forest cover, urbanization, steep slopes, and land system changes observed during the period. In absence of the observations, the simulated soil erosion was validated with the land degradation map of the watershed which showed a good correspondence. It is hoped that the results from this work would inform policymaking on soil and water conservation measures in the data-scarce mountainous Kashmir Himalaya.
The Impact of National and School Contextual Factors on the Academic Performance of Immigrant Students
Authors: Finch Holmes , Hernández Finch Maria E. , Avery Brooke
Published: December 2021

The issue of immigration has become central to the politics of nations across the world, impacting many aspects of life over the last decade. Researches investigating educational achievement through a cross-national lens have found that immigrant children tend to exhibit lower academic achievement than their native born peers, and that these differences are exacerbated by both family level variables (e.g., socioeconomic status) as well as the school climate. The goal of the current study was to build on earlier work in this area by investigating the nature and degree to which national attitudes towards immigration have changed over time, and whether any such changes were associated with academic achievement for immigrant and native born students. In particular, the relationship between changing attitudes towards immigration and the achievement gap between native and immigrant students. Results of the study demonstrated that nations with more negative attitudes towards refugees in general, and those for which these attitudes became more negative over time had greater achievement gaps than did those nations with more positive attitudes. In addition, these change trajectories moderated relationships between teacher attitudes towards multiculturalism and academic achievement.
Clifford Fuzzy Support Vector Machine for Regression and Its Application in Electric Load Forecasting of Energy System
Authors: Wang Rui , Xia Xiaoyi , Li Yanping , Cao Wenming
Published: December 2021

Electric load forecasting is a prominent topic in energy research. Support vector regression (SVR) has extensively and successfully achieved good performance in electric load forecasting. Clifford support vector regression (CSVR) realizes multiple outputs by the Clifford geometric algebra which can be used in multistep forecasting of electric load. However, the effect of input is different from the forecasting value. Since the load forecasting value affects the energy reserve and distribution in the energy system, the accuracy is important in electric load forecasting. In this study, a fuzzy support vector machine is proposed based on geometric algebra named Clifford fuzzy support vector machine for regression (CFSVR). Through fuzzy membership, different input points have different contributions to deciding the optimal regression hyperplane. We evaluate the performance of the proposed CFSVR in fitting tasks on numerical simulation, UCI data set and signal data set, and forecasting tasks on electric load data set and NN3 data set. The result of the experiment indicates that Clifford fuzzy support vector machine for regression has better performance than CSVR and SVR of other algorithms which can improve the accuracy of electric load forecasting and achieve multistep forecasting.
Indoleamine 2,3-Dioxygenase 1: A Promising Therapeutic Target in Malignant Tumor
Authors: Song Xiaotian , Si Qianqian , Qi Rui , Liu Weidan , Li Miao , Guo Mengyue , Wei Lin , Yao Zhiyan
Published: December 2021

Tumorigenesis is a complex multifactorial and multistep process in which tumors can utilize a diverse repertoire of immunosuppressive mechanisms to evade host immune attacks. The degradation of tryptophan into immunosuppressive kynurenine is considered an important immunosuppressive mechanism in the tumor microenvironment. There are three enzymes, namely, tryptophan 2,3-dioxygenase (TDO), indoleamine 2,3-dioxygenase 1 (IDO1), and indoleamine 2,3-dioxygenase 2 (IDO2), involved in the metabolism of tryptophan. IDO1 has a wider distribution and higher activity in catalyzing tryptophan than the other two; therefore, it has been studied most extensively. IDO1 is a cytosolic monomeric, heme-containing enzyme, which is now considered an authentic immune regulator and represents one of the promising drug targets for tumor immunotherapy. Collectively, this review highlights the regulation of IDO1 gene expression and the ambivalent mechanisms of IDO1 on the antitumoral immune response. Further, new therapeutic targets via the regulation of IDO1 are discussed. A comprehensive analysis of the expression and biological function of IDO1 can help us to understand the therapeutic strategies of the inhibitors targeting IDO1 in malignant tumors.
Long-Term Patterns of Noise From Underwater Explosions and Their Relation to Fisheries in Southern California
Authors: Krumpel Anna , Rice Ally , Frasier Kaitlin E. , Reese Fairlie , Trickey Jennifer S. , Simonis Anne E. , Ryan John P. , Wiggins Sean M. , Denzinger Annette , Schnitzler Hans-Ulrich , Baumann-Pickering Simone
Published: December 2021

Acoustic deterrents can reduce marine mammal interactions with fisheries and aquacultures, but they contribute to an increasing level of underwater noise. In Southern California, commercially produced explosive deterrents, commonly known as “seal bombs,” are used to protect fishing gear and catch from pinniped predation, which can cause extensive economic losses for the fishing community. Passive acoustic monitoring data collected between 2005 and 2016 at multiple sites within the Southern California Bight and near Monterey Bay revealed high numbers of these small-charge underwater explosions, long-term, spatio-temporal patterns in their occurrence, and their relation to different commercial purse-seine fishing sectors. The vast majority of explosions occurred at nighttime and at many nearshore sites high explosion counts were detected, up to 2,800/day. Received sound exposure levels of up to 189 dB re 1 μPa2-s indicate the potential for negative effects on marine life, especially in combination with the persistence of recurring explosions during periods of peak occurrence. Due to the highly significant correlation and similar spatio-temporal patterns of market squid landings and explosion occurrence at many sites, we conclude that the majority of the recorded explosions come from seal bombs being used by the California market squid purse-seine fishery. Additionally, seal bomb use declined over the years of the study, potentially due to a combination of reduced availability of market squid driven by warm water events in California and regulation enforcement. This study is the first to provide results on the distribution and origin of underwater explosions off Southern California, but there is a substantial need for further research on seal bomb use in more recent years and their effects on marine life, as well as for establishing environmental regulations on their use as a deterrent.