bluuebunny/crossref_metadata_2025 huggingface dataset:
Outcomes of radical prostatectomy in treatment of locally advanced prostate cancer: clinical observations
Authors: Popov S. V. , Guseynov R. G. , Orlov I. N. , Sivak K. V. , Skryabin O. N. , Perepelitsa V. V. , Katunin A. S. , Yasheva S. Yu. , Zaytsev A. S.
Published: March 2023

Background. Radical prostatectomy in treatment of locally advanced prostate cancer is currently recommended as one of the stages of multimodal therapy. Despite this, the expediency of surgical intervention remains a subject of discussion: based on the results of their own research, supporters of surgical tactics for treatment of locally advanced prostate cancer point to the effectiveness and relative safety of radical prostatectomy, opponents point to the high probability of a positive surgical edge associated with the operation, local tumor recurrence, lymphogenic metastasis, and formation of distant metastases.

Aim. To evaluate the outcomes of laparoscopic radical prostatectomy performed in combination with expanded pelvic lymphadenectomy in treatment of prostate adenocarcinoma T3a–3bN0M0.

Materials and methods. The perioperative, functional, and oncological results of surgical treatment of patients with locally advanced prostate cancer (n = 32) aged between 46 years to 71 years were analyzed. The follow-up period averaged 9–36 months (median 13 months).

Results. Mean total duration of surgical intervention and mean volume of intraoperative blood loss were 182.69 ± 3.99 minutes and 253.06 ± 9.80 ml, respectively. Overestimation of the clinical stage of the disease, according to histological examination of the surgical material, was observed in 6.3 % of patients. After the intervention, the function of urinary retention was preserved and did not require correction in 65.6 % of men. In all patients 6 months after the operation, the urinary volume, maximum and mean urine flow rates were normalized, and there was a trend toward a decrease in the post-void residual volume. During the entire follow-up period, there were no signs of biochemical relapse in 78.1 % of patients. None of the participants dropped out of the study due to death.

Conclusion. Over the last 20 years in specialized medical periodicals, author teams from various countries have shown the immediate and remote (follow-up period from 3 to 20 years) outcomes of radical surgical treatment of locally advanced prostate cancer in at least 80,000 patients in total, while the criterion for exclusion from research was adjuvant therapy. The authors’ conclusions indicate the effectiveness and relative safety of surgical treatment of locally advanced prostate cancer, as well as the importance of extended pelvic lymphadenectomy, which allows to optimize the tactics of adjuvant therapy if necessary. The results of our own observations are completely comparable with the literature data. Currently, scientific research is continuing with the aim of improving the outcomes of surgical treatment of locally advanced prostate cancer, in particular clarifying the role of individual prognostic factors, improving prediction techniques and choosing a rational scheme of treatment measures.
Enhanced recovery program in surgical treatment of patients with germ cell tumors of the testicle: experience of a specialized hospital
Authors: Mamizhev E. V. , Berkut M. V. , Rumyantseva D. I. , Shchekuteev N. A. , Krotov N. F. , Sigaev A. M. , Podvigina N. I. , Nekrasov D. V. , Nosov A. K.
Published: March 2023

Background. Surgical treatment after chemotherapy is extremely difficult technically and should only be performed in a specialized medical center. The postoperative period after these surgical interventions is aimed not only at minimizing complications, but also at early mobilization and rehabilitation of patients. The principles of fast-track surgery, or ERAS (Enhanсed Recovery After Surgery) significantly reduce the incidence and degree of complications after various surgical interventions. However, the results of studies on the use of fast track in retroperitoneal lymphadenectomies have not yet been presented.

Aim. To determine the effect of enhanced recovery program on treatment outcomes in patients with germ cell tumors of the testicle after retroperitoneal lymphadenectomy.

Materials and methods. Retrospective analysis of 2 groups of patients (n = 93) treated at the N.N. Petrov National Medical Research Center of Oncology (Saint Petersburg) was performed. In the 1st group of patients, standard postoperative care after retroperitoneal lymphadenectomy was performed; in the 2nd group, fast track elements were used. Since the introduction of the ERAS protocol into clinical practice (September 2017), all patients have been included in the 2nd group.

Results. The presence or absence of preoperative preparation did not affect the incidence of intraoperative complications (p = 0.031). There were significant differences in the duration of hospitalization between the 1st and 2nd groups –15.3 and 11.9 days (p = 0.03), respectively. Assessment of the pain syndrome using the Numeric Rating Scale for Pain (NRS) showed that median pain level in the 1st group was significantly higher than in the 2nd group: 5 ± 1.5 and 3 ± 1.7, respectively (p = 0.04), which indicates a more severe and less controlled pain syndrome in the 1st group of patients. The rate of infectious complications in the postoperative wound in the 2nd group was 3 cases versus 13 in the 1st group (p = 0.009). The rate of lymphorrhea in 2nd group was significantly lower (p = 0.003), median drainage duration was higher in 1st group (p <0.05). In the 2nd group, 70.6 % of patients did not require drainage, which was an important factor in rapid rehabilitation.

Conclusion. The use of fast-track principles in patients after retroperitoneal lymphadenectomy significantly reduces the incidence of postoperative complications and rehabilitation time.
Sodium deoxyribonucleate effects on the status of cervical cancer patients after radiotherapy
Authors: Kozina Yu. V. , Slepov E. V. , Kashaeva O. V. , Pavlenko A. Yu. , Zukov R. A.
Published: March 2023

Background. Apart from surgery and medications, radiation therapy is one of the main treatment methods for malignant tumors of the cervix. However, its use is associated with high incidence of urological complications. In addition, the need for long-term treatment, reduced level of patients’ quality of life promote the necessity to minimize the frequency of urological complications and justify search and study of the most adequate methods of their prevention.

Aim. To evaluate the effect of radioprotector sodium deoxyribonucleate on clinical characteristics and quality of life of patients with cervical cancer after radiation treatment.

Materials and methods. 80 patients with cervical cancer treated in A.I. Kryzhanovsky Krasnoyarsk Regional Clinical Oncology Dispensary. Patients received chemoand radiotherapy with the 3D conformal radiotherapy method in combination with intracavity gamma therapy sources of high dose with subsequent application of radioprotector and without it.

Results. On the 3rd visit it was found that in patients with cervical cancer using a radioprotector, reduced red blood cells and flat epithelium cells content in the urine sediment, it may be due to the reparative and cytoprotective sodium deoxyribonucleate properties. In the assessment of the life quality after combined therapy completion with radioprotector, 60 % of patients’ responses to the health assessment questions of the last week differed from the comparison group. Undesirable phenomena associated with sodium deoxyribonucleate therapy not observed in cervical cancer patients during radiotherapy and subsequent observation period.

Conclusion. Conformal external beam radiation therapy in combination with long-term intramuscular administration of a radioprotector has advantages compared to 3D conformal radiation therapy. This method reduces the severity of post-radiation side effects, increases time to development of hematological toxicity in the context of combination chemoradiotherapy, and reduces urothelial damage caused by chemoradiotherapy.
De verdugos y víctimas: la imagen del maltratador en el discurso publicitario de las instituciones andaluzas
Authors: Alcaide Lara Esperanza
Published: March 2023

En la actualidad, dada la situación de desigualdad que padece la mujer por razones de género, son abundantes las campañas publicitarias institucionales que, en un intento de erradicarla, abordan esta problemática y sus consecuencias: desde la brecha salarial hasta la violencia machista. El éxito o fracaso de estas campañas viene condicionado por la imagen de los agentes que intervienen en estas acciones discriminatorias e injustas que ofrece la propia institución, como responsable de los materiales comunicativos (entre ellos el lingüístico), que se utilizan en estos discursos: de dicha imagen dependerá el impacto que el mensaje cause en la ciudadanía. Este trabajo se centra en la figura del maltratador. Se analizan 64 carteles de diferentes campañas del Instituto Andaluz de la Mujer (IAM) de la Junta de Andalucía y de dos ayuntamientos andaluces (Sevilla y Málaga). Siguiendo la tesis del continuo social formado por las imágenes proyectadas en la interacción (Hernández Flores, 2013), analizamos, a través del discurso de la institución, los efectos que llega a tener la imagen proyectada de este en la configuración de la imagen de la propia mujer, casi siempre en una posición de víctima pasiva de esta situación de injusticia. El marco teórico de este trabajo es el Análisis social del discurso (Bravo, 2015, 2020) y el Análisis Crítico del Discurso (Van Dijk, 2003), los estudios sobre la interrelación de la argumentación y la imagen social (Alcaide Lara, 2014, 2019, 2022), así como la Teoría de la Enunciación (Ducrot, 1986).
OLD BELIEVER CHURCH: ASPECTS OF LIFE IN MODERN CONDITIONS
Authors:   Rivne State University of the Humanities, Ukraine, MYSHKOV Victor , SHAMSUTDYNOVA-LEBEDYUK Tetyana ,   Rivne State University of the Humanities, Ukraine
Published: March 2023

The article reveals certain aspects of Ukrainian Old Believer life in modern conditions. It is noted that Old Believers were formed as a result of deep moral and religious searches in the Russian and Ukrainian societies of the 17th century. For more than three hundred years of its existence, it has revealed significant spiritual potential and social opportunities and has become an integral part of Ukrainian society. With Ukraine gaining independence, the Old Believers were able to rebuild religious buildings closed during the Soviet era, freely send and attend religious services, open Sunday schools, revive national traditions, etc. Modern Old Believers on the territory of Ukraine act as a self-sufficient structural element of the religious culture of Ukraine, having significant potential not only for their own preservation, but also for further development. Today, the Old Believers are aimed at expanding their extra-cult priorities. In social life, such priorities are charity, philanthropy, education; in the political sphere - striving for freedom of conscience and cooperation with government and public institutions; in the cultural field - promoting the spiritual improvement of society, the development of national culture; in religious - active church life. The Old Believer Ukrainian Church, which is a part of the large Old Believer Church, immediately, after the large-scale invasion of Russia on our territory, took a patriotic pro-Ukrainian position and clearly declared its condemnation of Russia's aggression against Ukraine. Representatives of the Bilokrynytsia Metropolitanate were active participants in the resistance to Russian aggression eight years ago. Today, they also take an active part in the defense of Ukraine's independence. Despite their Russian ethnic origin, the Old Believers have no ties to the ideology of the "Russian world", they are aware of themselves as a part of Ukrainian society. They occupy a prominent place in social, spiritual and interfaith life and remain a dynamic Christian denomination, and strengthen their own positions in Ukraine.
RIQUET PROBLEM FOR ONE MODEL EQUATION OF THE 4TH ORDER HYPERBOLIC TYPE
Authors:   Taras Shevchenko national University of Kyiv, Aleksandrovych I. M. , Lyashko S. I. ,   Taras Shevchenko national University of Kyiv, Lyashko V. I. ,   National University «Kyiv-Mohyla Academy», Lyashko N. I. ,   V. M. Glushkov Institute of Cybernetics of NAS of Ukraine, Kyiv, Ukraine, Sidorov M. V.–S. ,   Taras Shevchenko national University of Kyiv
Published: March 2023

Integral operators that transform arbitrary functions into regular solutions of hyperbolic equations of the second and higher orders are applied to solving boundary value problems. In particular, the Riquet problem for the Euler–Poisson–Darboux equation of the 4th order is posed and solved.
WELL-POSEDNESS OF A DIRICHLET PROBLEM FOR A HYPERBOLIC TYPE INTEGRO-DIFFERENTIAL EQUATION
Authors:   Taras Shevchenko national University of Kyiv, Anikushyn A. , Zhyvolovych O. ,   Taras Shevchenko national University of Kyiv
Published: March 2023

In the paper we consider a Dirichlet problem for an integro-differential equation with Volterra type integral term. Proving a priori estimates for the differential and integral parts, we provide negative norms’ a priori estimates for the operator of the problem. Based on the latest, we formulate theorems regarding the well-posedness of the formulated boundary value problem.
MODIFIED MODEL OF VIRAL BIINFECTION TAKING INTO ACCOUNT DIFFUSION PERTURBATIONS, CONCENTRATED INFLUENCES AND LOGISTIC DYNAMICS
Authors:   National University of Water and Environmental Engineering, Rivne, Ukraine, Baranovsky S. V. , Bomba A. Ya. ,   National University of Water and Environmental Engineering, Rivne, Ukraine
Published: March 2023

A model of viral biinfection has been modified to predict the development of the disease process, taking into account diffusion perturbations, concentrated influences, as well as the logistic dynamics of antigen and antibody populations. The solution of the original model singularly perturbed problem with a delay is presented in the form of numerically asymptotic approximations of solutions to the corresponding sequence of problems without delay. The results of computer experiments are presented, which demonstrate a decrease in the rate of model growth of the antigenic population, taking into account the diffusion «scattering» of the active factors of the process. Also illustrated is the exacerbation of the nature of the course of a previously stabilized chronic disease due to the redistribution of the resources of the immune system to overcome infection with another viral infection. It was noted that such exacerbation significantly increases under conditions of low model levels of logistical limitation of the volume of antibody synthesis. It is emphasized that an excessive increase in the model concentration of chronic disease antigens due to a too low level of logistical limitation of the antibody population leads to a significant predictive damage to the target organ and a corresponding decrease in the overall power of the immune response. Taking into account such an effect is important when predicting the development of the disease in practical decision-making situations regarding the formation of the most effective treatment programs, including the use of various concentrated effects of immunotherapy.
UNDAMENTAL POLYNOMIALS OF HERMITE’SINTERPOLATION FORMULA IN LINEAR NORMAL AND INEUCLIDEAN SPACES
Authors:   Taras Shevchenko national University of Kyiv, Kashpur O. F.
Published: March 2023

In a linear infinite-dimensional space with a scalar product and in a finite-dimensional Euclidean space the interpolation Hermite polynomial with a minimal norm, generated by a Gaussian measure, contains fundamental polynomials are shown. The accuracy of Hermit’s interpolation formulas on polynomials of the appropriate degree are researched.
Dichotomy and Convergence of the Public and the Private in Legal Personality of an Autonomous Institution
Authors: Golubtsov V. G.
Published: March 2023

Theoretical ideas about the balance between private law and public law in the activities of autonomous institutions today are not obvious, which often generates biased scientific judgments on many relevant issues. In the doctrine, the issue concerning the search for the optimal balance between public and private legal aspects and their correlation in relation to autonomous institutions has not actually been raised and has not been resolved. The ability to independently provide property for their current activities through participation in civil law relations, as a rule, is studied separately from the norms of public law, creating an unmistakable scientific idea of the exclusively civilistic content of the normative rules that determine the legal personality of autonomous institutions. The author addresses the problem of dualism in determining their status, making a theoretical attempt to coordinate public and private law in this area.

In the course of the study, the author demonstrates systemic interweaving of private and public principles when analyzing the status of autonomous institutions. At the same time, there is a lack of well-established theoretical guidelines for the study of relations in which the analyzed entities participate. This, according to the author, is the main reason for the negative nature of scientific research in recent years devoted to the study of such a subject of legal relations.

At the same time, realizing that the purpose of any research is to detect advanced and progressive problems, the author sees it necessary to take into account the dichotomy and convergence of the provisions of public and private law in the subsequent analysis and study of such a subject of legal relations as an autonomous institution.
Criminal Charge (Criminal Prosecution) as a Function of the Prosecutor’s Office of the Russian Empire after the Judicial Reform of 1864
Authors: Gorbachev V. P.
Published: March 2023

The paper examines the normative foundations and theoretical views of pre-Soviet and modern scholars on the concept and content of a criminal charge (criminal prosecution) as a function of the Prosecutor ‘s Office of the Russian Empire after the judicial reform of 1864. The author shows the correlation between this function and supervising function in the prosecutor’s office activities. The paper analyzes legal terminology related to criminal prosecution and shows that there is a dual approach of researchers to the concept of this function as a certain «requirement» or «activity». The author considers the content of the initial and final charges and related controversial issues, in particular on the implementation of prosecutorial criminal prosecution at the stage of preliminary investigation. The connection between pre-Soviet and modern science in approaches to the analysis of the accusation function is shown.

The author concludes that due to the judicial reform of 1864, the prosecutor’s office was assigned a new function of making charges, which became the main one in its activities. The legislation included «detection of crimes and prosecution of perpetrators» in the content of the prosecution function, but did not define the concept of prosecution. In this regard, the science and departmental regulations of the Prosecutor’s office in the content of criminal prosecution in a broad sense included almost all the activities of the prosecutor in the criminal process. The prosecutor initiated such prosecution by initiating criminal cases and during the preliminary investigation carried it out through prosecutorial supervision. The prosecutor initiated criminal prosecution against particular persons either directly at the initiation of a criminal case, or indirectly during the supervision of the investigation, or directly at the stage of trial in cases in which the investigation was not conducted. Despite the fact that the prosecutor did not initiate the initial charge in all criminal cases, at the stage of bringing to court he formulated his final charge in all cases in which he considered the guilt of the accused proven.
Pre-Trial Dispute Settlement Procedure with Participation of a Financial Commissioner: Procedural Challenges
Authors: Zaikov D. E.
Published: March 2023

The Institute of Financial Commissioner aims at effective pre-trial settlement of disputes between financial organizations and financial services consumers. At the same time, disputes not resolved in this manner are referred to the courts of general jurisdiction. The specifics of the legal status of the financial commissioner, peculiarities of the legal nature of the relations arising when considering a dispute between a financial institution and a consumer of financial services at a pre-trial stage, gaps in legal regulation result in the emergence of a number of important procedural problems: determination of the procedural status of persons involved in the dispute, application of the rules of generic and territorial jurisdiction, establishment of the procedure for consideration of the relevant categories of cases by courts of general jurisdiction, etc. The lack of legal regulation of procedural legislation in such cases, as well as full-fledged explanations of the Supreme Court of the Russian Federation on these issues, lead to the multidirectional and unsettled development of judicial practice, violation of the principle of legal certainty, emergence of barriers in the exercise of the right to court protection. The paper analyzes the above problems, the causes of their occurrence and suggests the ways to resolve them.
Entrepreneurship in the Knowledge Economy Era: Sociocultural Factors of Development
Authors: Basos E. V.
Published: March 2023

The knowledge economy is a new stage in the Russian economy, characterized by social focus, careful attitude to human potential, and a focus on creating conditions for the spiritual, moral and professional development of citizens. Intellectual capital in post-industrial relations is the main economic source and object of investment and intellectual property law is a key element in the diffusion of innovations. In the knowledge economy, special attention should be given to non-material factors of social development, such as culture, science, and education. The author of the paper explores the role of these social institutions in the process of the citizens’ entrepreneurial activity enhancement, substantiates the need to ensure their interconnection and integration into economic circulation. The analysis of the regulatory legal framework made it clear that the legislator pays little attention to the motivational and regulatory functions of culture. It is also important to note the problems associated with the science management and the lack of effective legislation on innovation and scientific and technical activities, and to establish the need to develop and implement a system of continuous entrepreneurial education.
Peculiarities of Investigative Proceedings against Lawyers
Authors: Stelmakh V. Yu.
Published: March 2023

The paper deals with the peculiarities of investigative proceedings against lawyers that are regulated by the legislation of the Russian Federation. The author proposed to consider all actions that restrict the rights of a lawyer directly in the course of an investigative action, and not as a result of an investigative action, as investigative actions carried out «in relation to lawyers». At the same time, these actions can be carried out with the direct participation of a lawyer, as well as without him. The main purpose of the legislative establishment of the peculiarities of the production of investigative actions is to create a system of guarantees against attorney-client privilege violation, to prevent the use of information provided by the defendant to the lawyer in the framework of special trust relationships that develop in the provision of legal assistance in proving. The peculiarities provided for by law do not apply to investigative actions performed in connection with the commission of a criminal act by a lawyer. The paper scrutinizes the content of the features of conducting investigative actions: the range of actions, the production of which requires judicial permission, is determined; the rights of such a participant in an investigative action as an authorized representative of the bar association are disclosed; the concept of a lawyer’s dossier (lawyer’s proceedings) is detailed; the procedure for seizing the documents included in it is investigated.
Volumetry versus linear diameter lung nodule measurement: an ultra-low-dose computed tomography lung cancer screening study
Authors: Suchilova Maria M. , Blokhin Ivan A. , Aleshina Olga O. , Gombolevskiy Victor A. , Reshetnikov Roman  V. , Bosin Viktor Yu. , Omelyanskaya Olga V. , Vladzymyrskyy Anton V.
Published: March 2023

BACKGROUND: The DutchBelgian Randomized Lung Cancer Screening Trial (NELSON) used a volume-based protocol and significantly reduced the prevalence of false-positive results (2.1%).
AIM: To compare the performance of manual linear diameter and semi-automated volumetric nodule measurement in the pilot project Moscow Lung Cancer Screening ultra-low-dose computed tomography pilot study.
MATERIALS AND METHODS: The study included individuals with a lung nodule of at least 4 mm on baseline-computed tomography of the Moscow lung cancer screening between February 2017 and February 2018, without verified lung cancer diagnosis until 2020. The radiation dose was selected individually and did not exceed 1 mSv. All scans were assessed by three blinded readers to measure the maximum and minimum transversal nodule diameter and extrapolated volume. As a reference value of size and volume, the average value from the results of expert measurements was obtained. A false-positive nodule was defined as a nodule 6 mm/100 mm3 and a false-negative nodule as a nodule 6 mm/100 mm3.
RESULTS: Overall, 293 patients were included (166 men; mean age, 64.6 5.3years); 199 lung nodules were 6 mm/100 mm3 and 94 were 6 mm/100 mm3. Regarding volumetric measurements, 32 [10.9%; 4 false-positive, 28 false-negative], 29 [9.9%; 17 false-positive, 12 false-negative], and 30 [10.2%; 6 false-positive, 24 false-negative] nodule discrepancies were reported by readers 1, 2, and 3 respectively. For linear diameter measurement, 92 [65.5%; 107 false-positive, 85 false-negative], 146 [49.8%; 58 false-positive, 88 false-negative], and 102 [34.8%; 23 false-positive, 79 false-negative] nodule discrepancies were reported by readers 1, 2, and 3 respectively.
CONCLUSIONS: The use of lung nodule volumetry strongly reduces the number of false-positive and false-negative nodules compared with nodule diameter measurements, in an ultra-low-dose computed tomography lung cancer screening program.
Phyto-stimulating activity of the paracetamol-containing waste biodestruction product
Authors: Vikhareva Elena V. , Mishenina Irina I. , Agafontseva Anastasia V. , Rychkova Marina I.
Published: March 2023

Currently, the search for effective ways to dispose of pharmaceutical waste, including the use of microgerms, is relevant, which makes it possible to obtain products with new useful, in particular, phytostimulating properties. Our previous researches have shown that the product of bacterial destruction of paracetamol exhibits frank phytostimulating properties toward medicinal plants of the Lamiaceae, Plantaginaceae, Urticaceae, Asteraceae can be used as an inducer of accumulation of biologically active substances in them.

The purpose of this work is to investigate the effect of the biodegradation product of paracetamol on the amount of glycans, biomass, size and anatomical features of linseeds Linum usitatissimum L. (Linaceae family).

Materials and methods. The work used a product of biodegradation of paracetamol (PBP) obtained on the basis of the laboratory of alkanotrophic microorganisms of the Institute of Ecology and Genetics of Microorganisms of the Ural Branch of the Russian Academy of Sciences (Perm) from the pharmaceutical substance paracetamol with an expired expiration date. The study of the phytostimulating effect of PBP in relation to common flax was carried out on the basis of the A. G. Genkel Botanical Garden of the Perm State National Research University. The content of glycans was determined by gravimetric method. A comparative analysis of the anatomical structure of seeds was carried out using the Motic DM-111 digital microscope and the Motic Play and Motic Educator software.

Results. When processing flax seedlings of ordinary PBP, the amount of glycans in seeds increased by 6%, the total collection of seed biomass by 20.5%, the size (length) of seeds by 2% compared to the control (water). Biometric parameters of the mucous layer of seeds collected from the area treated with PBP increased by 10% the control in comparison.

Conclusion. The biodegradation product of paracetamol has a stimulating effect on the medicinal plant of the flax family (Linaceae) flax Linum usitatissimum L., increasing the content of polysaccharides, the total collection of seed biomass and their size.
Fadiga e Dor Osteomuscular em Profissionais de Enfermagem de Urgência Emergência Hospitalar
Authors: Oliveira Russi Pereira Aline , Santos Sergio Valverde Marques dos , Dalri Rita de Cássia de Marchi Barcellos , Silva Policardo Gonçalves da , Silva Luiz Almeida da , Robazzi Maria Lucia do Carmo Cruz
Published: March 2023

Avaliar queixas de fadiga e dor osteomuscular em profissionais de enfermagem de urgência e emergência hospitalar. Estudo transversal e quantitativo, realizado com 37 profissionais de enfermagem do setor de urgência e emergência de um hospital. Para coleta de dados foram utilizados três instrumentos: um de caracterização, a Escala de Fadiga de Chalder e o Diagrama de Corlett. Os dados coletados foram analisados de forma descritiva e inferencial. A maioria dos participantes era do sexo feminino, solteira, com idade média de 30,5 anos, sem hábitos de atividade física. Na somatória dos escores dos itens de fadiga, 35,1% apresentaram fadiga. Em relação à dor osteomuscular, a região mais relatada foi a coluna cervical. Houve associações entre dores osteomusculares dos membros superiores com as variáveis atividade física, horas de sono, dupla jornada e carga diária de trabalho, bem como associações das dores nos membros inferiores com as variáveis de estado civil, prática de atividade, horas de sono, tempo de profissão na enfermagem e de atuação na instituição (P<0,05). Parte dos trabalhadores apresentou fadiga e dores osteomusculares, evidenciando a necessidade de uma melhor qualidade de vida no trabalho dos profissionais de enfermagem da urgência e emergência.
Palavras-chave: Fadiga. Dor Musculoesquelética. Saúde do Trabalhador. Enfermagem em Emergência. Serviço Hospitalar de Enfermagem.
 
 
Abstract
To evaluate complaints of fatigue and musculoskeletal pain in nursing professionals of urgency and hospital emergency. Cross-sectional and quantitative study, carried out with 37 nursing professionals in the urgency and emergency department of a hospital. For data collection, three instruments were used: one for characterization, the Chalder Fatigue Scale and the Corlett Diagram. The collected data were analyzed in a descriptive and inferential manner. Most of the participants were female, single, with an average age of 30.5 years, with no physical activity habits. In the sum of the scores of the fatigue items, 35.1% had fatigue. Regarding musculoskeletal pain, the most reported region was the cervical spine. There were associations between musculoskeletal pain in the upper limbs with the variables  physical activity, hours of sleep, double shiftand daily workload, as well as associations of pain in the lower limbs with the variables of marital status, practice of activity, hours of sleep, time spent in nursing and working at the institution (P <0.05). Part of the workers presented fatigue and musculoskeletal pain, showing the need for a better quality of life in the work of the urgency and emergency nursing professionals.
Keywords: Fatigue. Musculoskeletal Pain. Worker's Health. Emergency Nursing. Nursing Service, Hospital.
Responses of Saccharomyces cerevisiae Cells Grown in Cultures Prepared from Different Tea Infusions to Oxidative Stress
Authors: KIRMIZIKAYA Görkem , OKUTAN Tuba , KİREÇCİ Oğuz Ayhan , YILMAZ Prof. Dr.  Ökkeş
Published: March 2023

Tea is one of the most consumed beverages. Saccharomyces cerevisiae, a model organism in studies on oxidative stress and toxicology, was used to investigate the effects of tea on oxidative stress induced by H2O2. S. cerevisiae cultures were prepared from black, green and white tea infusions and incubated at 30°C for 72 hours. Glutathione-S-transferase enzyme activity and total protein spectrophotometric, malondialdehyde, glutathione and alpha-tocopherol and ergosterol analyses from cell pellets obtained from cultures were performed by HPLC, and fatty acids were performed by GC device. Although protein level in tea infusion groups was higher (p
Meniscus heterogeneity and 3D-printed strategies for engineering anisotropic meniscus
Authors: Du Ming-Ze , Dou Yun , Ai Li-Ya , Su Tong , Zhang Zhen , Chen You-Rong , Jiang Dong
Published: March 2023

The meniscus is a fibrocartilaginous tissue of the knee joint that plays an important role in load transmission, shock absorption, joint stability maintenance, and contact stress reduction. Mild meniscal injuries can be treated with simple sutures, whereas severe injuries inevitably require meniscectomy. Meniscectomy destroys the mechanical microenvironment of the knee joint, leading to cartilage degeneration and osteoarthritis. Tissue engineering techniques, as a strategy with diverse sources and customizable and adjustable mechanical and biological properties, have emerged as promising approaches for the treatment of meniscal injuries and are represented by 3D printing. Notably, the heterogeneity of the meniscus, including its anatomical structure, cell phenotype, extracellular matrix, and biomechanical properties, is crucial for its normal function. Therefore, the construction of heterogeneous tissue-engineered menisci (TEM) has become a research hotspot in this field. In this review, we systematically summarize the heterogeneity of menisci and 3D-printed strategies for tissue-engineered anisotropic menisci. The manufacturing techniques, biomaterial combinations, surface functionalization, growth factors, and bioreactors related to 3D-printed strategies are introduced and a promising direction for the future research is proposed.
AN OVERVIEW ON THE MINERALOGY AND CRISTALLOGRAPHY FIELD COURSE GUIDE AT THE SERIDÓ PEGMATITIC PROVINCE: A CONTRIBUTION FOR UNDERGRADUATE GEOLOGY STUDENTS OF THE FEDERAL UNIVERSITY OF PERNAMBUCO, BRAZIL
Authors: Da Paixão Mariana Sousa , Santos Lauro Cézar Montefalco de Lira , Lima Haroldo Monteiro
Published: March 2023

This report presents basic guidelines to help undergraduate first year geology students at the Federal University of Pernambuco Brazil. It reviews general aspects of the Mineralogy field trip presenting a comprehensive review on pegmatite classification, regional geology of the Seridó Pegmatitic Province (Rio Grande do Norte and Paraíba states) as well as local geological aspects of three mines that are visited and locally mapped. During the field trip, the Dedego, Pendanga and Sítio Mulungu mines are visited, offering the opportunity to describe pegmatites and host rocks in one of the most famous regions that produce industrial minerals and gemstones for commercial purposes. During the visit, crystallographic and physical aspects of granitic pegmatite-related minerals are discussed, including didactical varieties of quartz, feldspars, mica, tourmaline, garnet and beryl crystals. Mining aspects on pegmatitic rocks in the region are also accessed, allowing the first-year student to have an early contact with mineral exploration and mining companies and their professionals, which will be of great importance for their development during the geology undergraduate course.
Imputação de Valores Omissos em Análise Descritiva de Dados, em R
Authors: Salambiaku Luzizila , Prata Paula , Ferrão Maria Eugénia
Published: March 2023

Os valores omissos representam um problema frequente no processo de análise de dados. Neste artigo foram comparados seis métodos distintos de imputação, disponíveis no software R e avaliado o seu desempenho em conjuntos de da­dos relacionados com a área da educação. Foi estudada uma amostra de 20408 estudantes para testar os seis algoritmos em quatro conjuntos de dados gerados por simulação com diferentes percentagens de valores omissos, considerando 5%, 10%, 15% e 20% nas variá­veis de interesse. Foram explorados métodos de imputação simples (Média, Mediana e Moda), métodos baseados em aprendizagem automática (kNN e bPCA) e um método de imputação múltipla (MICE). Foi avaliado o desempenho de cada método calculando os respetivos erros de imputação através as métricas RMSE e MAE. Os resultados obtidos mostram que a imputação pela Moda forneceu quase de forma constante menores valores de erro.
Aberrant expression of COL4A1 in age-related cataract and its effect on cell proliferation, apoptosis and gene expression changes
Authors:   Department of Optometry, Xi’an Medical University, Xi’an 710021, Shaanxi Province, China, Zhu Dan , Wang Li ,   Department of Optometry, Xi’an Medical University, Xi’an 710021, Shaanxi Province, China, He Yuan ,   Department of Optometry, Xi’an Medical University, Xi’an 710021, Shaanxi Province, China; Department of Ophthalmology, The Second Affiliated Hospital of Xi’an Medical University, Xi’an 710038, Shaanxi Province, China, Zhang Hui-Zi ,   Department of Optometry, Xi’an Medical University, Xi’an 710021, Shaanxi Province, China
Published: March 2023

AIM: To evaluate the regulation of the aberrant expression of collagen type IV alpha 1 chain (COL4A1) in the development of age-related cataract (ARC).
METHODS: Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and Western blot analysis were employed to evaluate the expression of COL4A1 in ARC patients and healthy controls. The proliferation, apoptosis, cell cycle and epithelial-mesenchymal transition (EMT) of human lens epithelial cell (HLE-B3) were further analyzed under the condition of COL4A1 gene silence. Alteration of gene expression at mRNA level after knockdown COL4A1 were also evaluated by qRT-PCR on HLE-B3 cells.
RESULTS: The aberrant expression of COL4A1 was identified a clinically associated with the ARC. Silencing of COL4A1 promoted the apoptosis and inhibited the proliferation of HLE-B3 by blocking the cell cycle. Moreover, COL4A1 gene silence didn’t affect the cytoskeleton of HLE-B3 but down-regulated the Collagen type IV Alpha 2 Chain (COL4A2), paired box 6 (PAX6), procollagen-lysine 2-oxoglutarate 5-dioxygenases 1 (PLOD1) and procollagen-lysine 2-oxoglutarate 5-dioxygenases 2 (PLOD2) expression levels in HLE-B3 cells. Silencing the COL4A1 gene induced EMT of the HLE-B3 cells by promoting the transforming growth factor beta (TGF-β) expression.
CONCLUSION: Silencing of COL4A1 induces S-phase arrest, also inhibits the proliferation and enhance HLE-B3 apoptosis and EMT, and down-regulates the expression of COL4A2, PAX6, PLOD1 and PLOD2. Thus, the expression alteration of COL4A1 may play a critical role in the pathogenesis of ARC.
Transpalpebral intraocular pressure measurement by Diaton compared to Goldman applanation tonometer in myopic eyes before and after transepithelial photorefractive keratectomy in Saudi Arabia
Authors:   Department of Ophthalmology, College of Medicine, Qassim University, Buraidah 51452, Saudi Arabia, Alzuhairy Sultan
Published: March 2023

AIM: To compare intraocular pressure (IOP) measured via the trans palpebral IOP (tpIOP) method using a Diaton or with a Goldman applanation tonometer (GAT) and study the determinants of IOP difference in eyes undergoing transepithelial photorefractive keratectomy (TPRK) for myopia.
METHODS: This cross-sectional validation study was held in 2020 in an eye hospital in Saudi Arabia. IOP was measured by Diaton and GAT before treatment, after one week, and one month of TPRK. It is considered if IOP difference by Diaton and GAT was less than ±2 mm Hg acceptable. The IOP difference was tested if correlated to spherical equivalent (SE), central corneal thickness (CCT), age, gender, or tpIOP.
RESULTS: Totolly 200 myopic eyes of 100 patients were included in the study. The mean difference of IOP measured by two methods before TPRK, 1wk, and 1mo after TPRK were 0.790, -0.790, and -0.920 mm Hg, respectively (P<0.001). Diaton could measure IOP effectively 89.5% eyes before TPRK and 82% and 84% at 1wk and 1mo after TPTK, respectively. At week 1, IOP differences were significantly correlated to baseline CCT (P=0.02) and tpIOP at week 1 (P<0.001). One month after TPRK, only tpIOP was significantly correlated to the difference in IOP (P<0.001).
CONCLUSION: Diaton is a good screening tool for IOP before TPRK. It helps in monitoring IOP after surgery. Although more practical, it is less efficient than GAT. In eyes with high myopia and low tpIOP before surgery, IOP post-TPRK by Diaton and GAT could differ.
Difference of anterior and posterior orbital development in patients with congenital microphthalmia: a retrospective cohort study from China
Authors:   Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Lab, Beijing 100730, China, Zhang Ju , Xian Jun-Fang ,   Department of Medical Imaging Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China, Chang Qing-Lin ,   Department of Medical Imaging Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China, Li Dong-Mei ,   Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Lab, Beijing 100730, China
Published: March 2023

AIM: To evaluate volume differences between anterior and posterior orbit and demographic characteristics of Chinese patients with congenital microphthalmia.
METHODS: A retrospective cohort study, involving 169 unilateral congenital microphthalmia patients aged between 1 and 57 years old was conducted. Three-dimensional images of the orbit were generated from past CT scans, and digital orbital volume comprehensive measurement was done. The measured data included orbital volume (OBV), posterior orbital volume (POV), orbital width (OBW), orbital height (OBH), orbital depth (OBD), and posterior orbital area ratio.
RESULTS: Significant differences were observed among OBV, POV, OBW, OBH, and OBD of the affected and unaffected eyes in different age-based groups (all P<0.001). Among them, OBH had the greatest different. The mean microphthalmic to contralateral ratio (MCR) of OBV, POV, OBW, and OBH continuously increased from 1 to 3 years old, whereas the MCR of POV decreased from 3 to 17 years old. The MCR of OBD was not found to be correlated to age. There was no significant difference between OBV, POV, OBW, and OBH in ages from 13 years old to adulthood (all P>0.05). The difference in posterior orbital area ratio between the affected and unaffected groups was not statistically significant (P>0.05).
CONCLUSION: OBH is maximally affected, whereas OBD is minimally affected by microphthalmia. Posterior orbital retardation began 2y prior to orbital retardation and occurred at 3 years old in the affected eye, suggesting that intervention therapy should be done before the age of 4.
Distribution and associated factors of intraocular pressure in the older population: Tehran Geriatric Eye Study
Authors:   Noor Research Center for Ophthalmic Epidemiology, Noor Eye Hospital, Tehran 19839-63113, Iran, Hashemi Hassan , Aghamirsalim Mohammadreza ,   Translational Ophthalmology Research Center, Tehran University of Medical Sciences, Tehran 1157715354, Iran, Yekta Abbasali ,   Department of Optometry, School of Paramedical Sciences, Mashhad University of Medical Sciences, Mashhad 3453545, Iran, Hashemi Alireza ,   Noor Ophthalmology Research Center, Noor Eye Hospital, Tehran 1968653111, Iran, Sajadi Masoumeh ,   Noor Ophthalmology Research Center, Noor Eye Hospital, Tehran 1968653111, Iran, Khabazkhoob Mehdi ,   Department of Basic Sciences, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran 1968653111, Iran
Published: March 2023

AIM: To determine the distribution and associated factors of intraocular pressure (IOP) in an Iranian elderly population 60 years of age and above.
METHODS: The present report is part of the Tehran Geriatric Eye study (TGES), a population-based cross-sectional study that was conducted on the residents of Tehran 60 years of age and above. The sampling was performed using multistage stratified random cluster sampling methods from 22 districts of Tehran, Iran. Demographic and history information, blood samples, and blood pressure were collected from all participants. Ocular examinations included measurement of uncorrected and best-corrected visual acuity, objective and subjective refraction, and slit-lamp biomicroscopy. The IOP was measured using Goldmann applanation tonometry (GAT). Corneal imaging and ocular biometry were performed using Pentacam AXL.
RESULTS: The data of 3892 eyes of 2124 individuals were analyzed for this report. The mean age of the study participants was 66.49±5.31y (range: 60 to 95y). The mean IOP was 15.2 mm Hg (95%CI: 15.1 to 15.4), 15.3 mm Hg (95%CI: 15.1 to 15.5) and 15.1 mm Hg (95%CI: 15.0 to 15.3) in all participants, males, and females, respectively. Of the study participants, 1.3% had an IOP of ≥20 mm Hg. The mean IOP increased from 15.1 mm Hg in the age group 60-64y to 16.3 mm Hg in the age group ≥80y. According to the final multiple GEE model, the IOP was statistically significantly higher in men than in women. All the studied age groups, except for the 75-79-year-old age group, had significantly higher IOP compared to the 60-64-year-old age group. The IOP was significantly higher in underweight compared to other body mass index groups. Moreover, the IOP had a statistically significant direct relationship with the mean corneal power (mean CP), central corneal thickness (CCT), and systolic blood pressure.
CONCLUSION: The present study presents the distribution of IOP in an Iranian elderly population. A higher IOP (within the range 14 to 17 mm Hg) is significantly associated with older age, male sex, high systolic blood pressure, increased mean CP, and CCT. These factors should be considered in the clinical interpretation of IOP.
MENGEMBANGKAN KREATIVITAS ANAK USIA DINI MELALUI KEGIATAN BERMAIN KOLASE DAUN KERING DI DESA TANJUNG SARI
Authors: Sari Diana Martharita , Hibana Hibana , Fatmawati Fatmawati , Meilasari Devi , Hukamak Saiful
Published: March 2023

Kreativitas merupakan sikap yang harus dimiliki setiap anak usia dini, agar anak menjadi kreatif, bertanggung jawab, mandiri dapat terwujud untuk memperoleh sesuatu yang baru. Kolase adalah karya seni rupa yang dibuat dengan cara menempelkan bahan apa saja ke dalam satu komposisi yang serasi sehingga menjadi satu kesatuan karya yang bernilai estetika. Tujuan penelitian ini adalah untuk mendeskripsikan bagaimana cara mengembangkan kreativitas anak melalui kegiatan bermain kolase daun kering di Desa Tanjung Sari, Kecamatan Buay Madang Timur, Kabupaten Ogan Komering Ulu Timur, Provinsi Sumatera Selatan. Metode penelitian yang digunakan adalah metode kualitatif dengan pendekatan deskriptif. Teknik pengumpulan data yang digunakan adalah observasi, wawancara, dan dokumentasi. Penelitian ini menggunakan model analisis interaktif. Analisis data dimulai dengan keseluruhan data yang telah didapatkan dari berbagai sumber kemudian data tersebut ditelaah, proses analisis data dimulai dari pengumpulan data, reduksi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian menunjukan bahwa kolase daun kering dapat dijadikan metode dan teknik dalam mengembangkan kreativitas anak. Dalam implementasinya kolase daun kering dapat digunakan pendidik maupun orangtua untuk dijadikan metode dan teknik penunjang pembelajaran dalam mengembangkan kreativitas anak usia dini.