bluuebunny/crossref_metadata_2025 huggingface dataset:
Dependence of Intestinal Microbiota Composition on Distribution and Activity of Adipose Tissue in Nonalcoholic Fatty Liver Disease
Authors:   Malaya National Institute of Therapy, NAMS of Ukraine, Fadieienko G.D. , Kushnir I.E. ,   Malaya National Institute of Therapy, NAMS of Ukraine, Chernova V.M. ,   Malaya National Institute of Therapy, NAMS of Ukraine, Solomentseva T.A. ,   Malaya National Institute of Therapy, NAMS of Ukraine, Nikiforova Ya.V. ,   Malaya National Institute of Therapy, NAMS of Ukraine, Kurinna O.H. ,   Malaya National Institute of Therapy, NAMS of Ukraine, Galchynska V.Yu. ,   Malaya National Institute of Therapy, NAMS of Ukraine, Bondar T.N. ,   Malaya National Institute of Therapy, NAMS of Ukraine
Published: December 2022

Nonalcoholic fatty liver disease (NAFLD) pathogenesis displays a close relation with intestinal dysbiosis. Thus, the aim of this study was to investigate the intestinal microbiota (IM) composition and to determine the correlation of changes in its main phylotypes with the amount and activity of adipose tissue in NAFLD patients. Methods. The prospective study enrolled 114 NAFLD patients with metabolic disorders and 30 healthy subjects as the control group. Along with routine examination, the authors assessed intestinal microbiota composition by identifying total bacterial DNA and DNA of Bacteroidetes, Firmicutes, and Actinobacteria by means of a quantitative real-time PCR. Results. NAFLD patients showed a signifi cant decrease in the relative amount of Bacteroidetes with a simultaneous increase in the Firmicutes and an increase in Firmicutes/Bacteroidetes ratio compared with healthy subjects (p<0.05). NAFLD patients with concomitant overweight and obesity displayed a more significant imbalance of IM with an increase in the Firmicutes/Bacteroidetes ratio due to the inhibition of Bacteroidetes, compared with patients of normal body mass index. The revealed changes in the main phylotypes of IM in the examined patients were proven linked not only to an increase in body weight but also to the amount and activity of visceral adipose tissue. Furthermore, deviations in the gut microbiota composition had an impact on the formation and severity of steatosis. Conclusions. The study revealed an imbalance of IM in NAFLD patients. Further research in gut microbiota will help to elucidate their role in NAFLD pathogenesis and to lay a foundation for the development of individualized treatment.
New Records of Sciarid Species (Diptera, Sciaridae) from Ukraine. IV.
Authors: Babytskiy A. I. , Rubanovska N. V. , Bezsmertna O. O.
Published: December 2022

Five species of black fungus gnats are recorded from Ukraine for the first time: Bradysia forficulata (Bezzi, 1914), B. lobata Hondru, 1968, B. normalis Frey, 1948, B. urticae Mohrig & Menzel, 1992 and Lycoriella sativae (Johannsen, 1912). Distributions of these species are summarized and their diagnoses are provided.
Diversity and Density of Mollusca (Gastropoda and Bivalvia) Population in the Euphrates River at Al-Nasiriyah, Southern Iraq
Authors: Al-Yacoub G. A. Ali , Najim Sh. A. , Al-Khazali A. M.
Published: December 2022

The current study was conducted in one of the most important water sources in Iraq, the Euphrates river to evaluate the diversity and density of Gastropoda and Bivalvia by using appropriate biodiversity indices. The samples were taken monthly from the river sediments, during the period from 1 July 2018 to 1 June 2019 from 3 stations, the distance between the first and second stations is 5 km and the second and third station is 7 km. The results showed the presence of 9 species, 7 of them belong to the Gastropoda and 2 belong to the Bivalvia. The total number of Mollusca was 2675 ind/m2. The species Melanoides tuberculata (Muller 1774) showed more relative abundance in the Euphrates River during the study period. The highest value for richness was recorded in March at station 3, while the Shannon Wiener diversity index, the results showed that the highest values ​​were in April and May for all sites, and the highest value for eveness was recorded in January at Station 3, while the highest value for dominance was during October at station 3. Moreover, the current study included the monthly measurement of five environmental factors: water temperature, pH, salinity, dissolved oxygen, and organic matter.
Invertebrate Communities Associated to Parastacus pugnax (Decapoda, Parastacidae) Northern Patagonian Populations (38°S, Araucania, Chile): a First Exploratory Analysis
Authors: De los Rios-Escalante P. R. , Jara P. , Contreras A. , Latsague M. , Lara G.
Published: December 2022

The burrowing crayfish Parastacus pugnax (Poeppig, 1835) inhabits the flooded plains in the central part of Chile (32–38°S), where it coexists with another representaives of invertebrate fauna. The aim of this study was to give the first description based on exploratory data of invertebrates associated to P. pugnax habitats in the Araucanía region, Chile. For comparison, published data on two similar habitats without P. pugnax populations were considered as outgroups. The obtained results revealed marked differences in species composition among sites with presence of P. pugnax, and without this species. A small number of species (1–5) was identified in the studied sites; Cladocera Simocephalus expinosus group was the most numerous and inhabited five of seven sites. Ecological and biogeographical topics were discussed.
Magyar Afázia Szűrőteszt: új szűrőeljárás a poststroke aphasia gyors felismerésére
Authors: Zakariás Lilla , Lukács Ágnes
Published: December 2022

Bevezetés: Bár a szerzett neurogén nyelvi zavarok (aphasiák)
szűrésére a nemzetközi gyakorlatban számos eljárás áll rendelkezésre, magyar
nyelven mostanáig nem létezett pszichometriai mutatókkal rendelkező aphasia
szűrőteszt. Célkitűzések: (1) A stroke következtében kialakuló
aphasiák szűrésének, a szűrés szempontjainak és eszközeinek nemzetközi
áttekintése. (2) Egy új, magyar nyelvű aphasia szűrőteszt bemutatása.
Módszer: A Magyar Afázia Szűrőteszt öt rövid, beszédértést
és beszédprodukciót vizsgáló feladatból áll. Öt–tíz perc alatt felvehető,
pontozása egyszerű, és eszközigénye minimális, így sikeresen használható olyan
klinikai helyzetekben is, amikor a vizsgálatra csak limitált idő áll
rendelkezésre. A tanulmányban két vizsgálatot mutatunk be, melyek alapján
értékeljük a teszt pszichometriai mutatóit és diagnosztikus pontosságát,
valamint meghatározzuk a súlyossági övezetek (enyhe, közepes, súlyos aphasia)
határértékeit a tesztben. A határértékek megállapítása 70 fős, poststroke
aphasiás mintán (35 nő; átlagéletkor: 61,4 év; a ’postonset’ átlaga: 12,6 hónap)
történt. Eredmények: A teszt diagnosztikus pontossága nagy,
szenzitivitása 92,5%, specificitása 88,5%. A teszt strukturális és konvergens
(MR = 0,68) validitása megfelelő, szubtesztjeinek belső
konzisztenciája jó (Mα = 0,74). A teszt összpontszáma alapján az aphasiás és nem
aphasiás stroke-betegek teljesítményét elválasztó érték (vágópont) 17.
Megbeszélés: A teszt alkalmas az aphasiát mutató és nem
mutató stroke-betegek elkülönítésére. Segítségével a páciens teljesítménye az
enyhe (14–17 pont), a közepes (9–13 pont) vagy a súlyos (0–8 pont) aphasia
övezetébe sorolható. Vizsgálataink eredményei a teszt megbízhatóságát és
érvényességét támasztják alá. Következtetés: A teszt alkalmas a
poststroke aphasia gyanújának és diagnózisának megállapítására, valamint az
aphasia súlyosságának megítélésére. Az aphasia szűrésének és a teszt
használatának klinikai jelentőségét az áttekintésben megfogalmazott szempontok
tükrében részletesen tárgyaljuk. Orv Hetil. 2022; 163(50): 2000–2008.
A perifériás vérben keringő szabad DNS molekuláris vizsgálata epeúti malignitásokban
Authors: Csoma Szilvia Lilla , Bedekovics Judit , Veres Gergő , Árokszállási Anita , András Csilla , Méhes Gábor , Mokánszki Attila
Published: December 2022

Bevezetés: A perifériás vérben szabadon keringő tumoreredetű
DNS-ek lehetővé teszik cholangiocarcinomákban a molekuláris genetikai eltérések
tanulmányozását, akár a kemoterápiára adott válasz hatékony követését is.
Célkitűzés: A liquid (’folyékony’) biopszia alkalmazása
kedvező megoldás, hiszen a szövetinél sokkal egyszerűbben kivitelezhető, és
elkerülhető az ismételt invazív szövettani mintavétel. A liquidbiopszia-alapú
szekvenálás hatékonysága a tumor progressziójával és ezáltal a nagyobb
mennyiségű szabad DNS felszabadulásával növekszik. Módszer: A
jelen vizsgálatban klinikailag releváns pontmutációkat mutattunk ki epeúti
tumorok mind szövettani, mind liquid biopsziás mintáiból.
Eredmények: Újgenerációs szekvenálás alkalmazásával 33
betegből származó, szövettani és liquid biopszia során nyert DNS-mintákat
analizáltunk 67 génes szolidtumor-panelt felhasználva.
Megbeszélés: Dolgozatunkban egy minimálisan invazív
vizsgálati megközelítést mutatunk be a cholangiocarcinoma és az
epehólyag-daganat molekuláris genetikai eltéréseinek azonosítására.
Következtetés: A szabad DNS diagnosztikai alkalmazása a
tumorok térbeli heterogenitását tükrözi, ezáltal egy új megközelítés a precíziós
onkológiai kezelésekben. Orv Hetil. 2022; 163(50): 1982–1991.
The Role of Educational Psychology for Teachers in Learning Effectiveness
Authors: Azura Yuni , Tarsono Tarsono , Hermawan A. Heris , Ningsih Arum
Published: December 2022

This study is blackfaced with problems in learning processes, such as teachers do not understand the student's situation and condition, they apply incorrect methods, or the learning process tends boring. The important role of psychological education for teachers is to help them understand students' psychological aspects so that teachers have basic rules for applying effective learning techniques to particular student characteristics. This study aims to know the essential role of psychology for teachers in the learning process and the psychological scope for teachers in studying students. The study uses qualitative methods, which isa literature approach (library research). Researchers use documentaries to collect data. This study shows that teachers must study educational psychology. In educational psychology, there is much discussion of the problems associated with human development. So, as an educator, it is very important to understand educational psychology.Penelitian ini dilatar belakangi dengan adanya masalah dalam proses pembelajaran seperti guru tidak memahami situasi dan kondisi siswa, penerapan metode yang kurang tepat dan proses pembelajaran cenderung membosankan. Peran penting pembelajaran psikologi pendidikan bagi guru membantu dalam   mempelajari aspek psikologis siswa agar guru memiliki aturan   dasar   untuk   menerapkan   teknik   pembelajaran   yang   efektif   yang   diterapkan   pada karakteristik   siswa   tertentu.  Penelitian ini bertujuan untuk mengetahui peranan penting psikologi bagi guru dalam proses pembelajaran dan mengetahui ruang lingkup psikologi bagi guru dalam mempelajari siswa. Penelitian ini menggunakan metode kualitatif dengan jenis pendekatankepustakaan (Library Research). Peneliti menggunakan studi dokumenter untuk pengumpulan data dalam penelitian. Hasil penelitian ini menunjukan bahwa sangat penting bagi guru dalam mempelajari psikologi pendidikan. Dalam psikologi pendidikan, banyak sekali pembahasan tentang masalah-masalah yang berkaitan  dengan perkembangan manusia.  Sehingga, sebagai pendidik sangat penting memahami psikologi pendidikan.
A Curriculum Analysis of the Moral Creed: the Pattern of Moral Formation
Authors: Hidayat Fitria , Wahidah Nida Fatmah , Mulyadi Yadi
Published: December 2022

The Moral Creed curriculum in SMPN 1 of the west Bandung district contains various subject materials that point to achieving noble character in daily life, such as doing dhuha prayer, reading asmaul husna, and reading the Qur'an. Although the curriculum has been adopted based on the 2015 article 1 rule dictating to students no. 23, there are problems, such as declining student morals, students still not being used to recitation, and even cannot do it. The study aims to analyze the Moral Creed curriculum in the central west Bandung district. This study is quantitative research using the library research method. The primary data is through interviews, and secondary data is through books and other support sources. The data analysis used is analysis content. This study suggests that the Moral Creed curriculum at SMPN 1 should develop the curriculum to humanize humans and require a proper education method in the learning process.Kurikulum Akidah Akhlak di SMPN 1 Porongpong Kabupaten Bandung Barat memuat berbagai materi pelajaran yang mengarahkan pada tercaIslamic Educationnya akhlak mulia dalam kehidupan sehari-hari seperti mengerjakan sholat dhuha, membaca asmaul husna, dan membaca al-Qur’an. Meskipun sudah diterapkan kurikulum sesuai dengan peraturan Mendikbud RI No 23 Tahun 2015 Pasal 1, terdapat beberapa masalah seperti menurunnya akhlak siswa dan siswa masih belum terbiasa mengaji bahkan ada siswa yang tidak bisa mengaji. Penelitian ini bertujuan untuk menganalisis kurikulum akhlak di SMPN 1 Paronpong Kabupaten Bandung Barat Indonesia. Jenis penelitian ini termasuk penelitian kuantitatif dengan menggunakan metode library reseach, sumber data dalam penelitian ini yaitu sumber data primer melalui wawancara dan data sekunder melalui buku serta sumber pendukung lainnya. Analisis data yang digunakan yaitu konten analisis.  Hasil penelitian ini menunjukan bahwa kurikulum akidah akhlak di SMPN 1 Porongpong mengembangkan kurikulum untuk memanusiakan manusia, untuk mewujudkan hal tersebut dibutuhkan metode pendidikan yang tepat dalam proses pembelajaran.
Instillation of Prayer Values in Nature Shaping Students' Personalities
Authors: Nuryana Ari , Suhartini Andewi , Basri Hasan
Published: December 2022

Efforts made by educators in shaping the personality of good students have been carried out but have not produced maximum results. This study aims to identify the cultivation of prayer values This research uses a qualitative approach with a case study method. The results of the study show that: 1) the values of prayer that are instilled are religious values, such as being obedient to worship & loving cleanliness. Moral values, such as honesty, discipline,  responsibility are not arrogant & polite. Social values, such as empathy & tolerance; 2) the process of inculcating the values of prayer is carried out in three stages, namely value transformation through PAI learning in class, value transactions through material appreciation & trans internalization of values through habituation programs; 3) the material used is PAI material related to fiqh; 4) the methods used are habituation of prayer, habituation of recitations of the Qur'an, habituation of Asmaul Husna, habituation of greeting in the morning, habituation of GPS & honesty stalls; 5) evaluation is carried out on the achievement of student personality using attitude assessment which results in prayer worship can shape the student's personality; 6) supporting factors for inculcating the values of prayer, namely the existence of worship facilities, school policies and partnerships with parents. While the inhibiting factors are less supervision from parents & a less supportive living environment.Ikthiar yang dilakukan oleh pendidik dalam membentuk kepribadian siswa yang baik telah dilakukan akan tetapi belum membuahkan hasil yang maksimal.Penelitian ini bertujuan untuk mengidentifikasi penanaman nilai-nilai sholat . Penelitian ini menggunakan pendekatan kualitatif dengan metode studi kasus. Hasil penelitian menunjukkan bahwa 1) nilai-nilai ibadah shalat yang ditanamkan yaitu nilai religius, seperti taat beribadah & cinta kebersihan. Nilai moral, seperti jujur, disiplin, tanggungjawab, tidak sombong & sopan santun. Nilai sosial, seperti empati & toleransi; 2) proses penanaman nilai-nilai ibadah shalat dilakukan melalui tiga tahap, yaitu tranformasi nilai melalui pembelajaran PAI di kelas, transaksi nilai melalui penghayatan materi & trans internalisasi nilai melalui program pembiasaan; 3) materi yang dipakai adalah materi PAI yang berkaitan dengan fikih; 4) metode yang digunakan yaitu pembiasaan shalat, pembiasaan tilawah al-Qur’an, pembiasaan asmaul husna, pembiasaan sapa pagi, pembiasaan GPS & warung kejujuran; 5) evaluasi dilakukan pada hasil capaian kepribadian siswa menggunakan penilaian sikap yang hasilnya ibadah shalat dapat membentuk kepribadian siswa; 6) faktor pendukung penanaman nilai-nilai ibadah shalat yaitu adanya sarana ibadah, kebijakan sekolah dan kemitraan dengan orangtua. Sedangkan faktor penghambatnya yaitu pengawasan yang kurang dari orangtua & lingkungan tempat tinggal yang kurang mendukung.
The Creativity of Islamic Religious Education Teachers for Effective Learning
Authors: Fauzan Farhan Ahmad , Hasbiyallah Hasbiyallah , Fikri Miftahul
Published: December 2022

Learning in schools currently cannot be effective due to the lack of organized learning by the teacher. This study was to determine the effect of the creativity of Islamic Religious Education teachers in Elementary Schools or Madrasah Ibtidaiyah on effective learning. The research method is a quantitative method with a post-positivist approach. The population in this study was 25 teachers of Islamic education at the Elementary School or Madrasah Ibtidaiyah in the city of Bandung. While the sample is 18 teachers. Data collection through questionnaires. The data analysis technique used data normality test and correlation test. Hypothesis testing using a  path analysis of 0.05. The results of the normality test of the data showed that the data were normally distributed, which was indicated by the distribution of the points on the Q-Q diagram on a diagonal line in both the teacher creativity test and effective learning. The results of the correlation test show that there is a positive relationship between teacher creativity in realizing effective learning with a coefficient of 0.522. The conclusion from the results of this study is that there is an influence of teacher creativity in an effort to realize effective learning. So the more Islamic Religious Education teachers increase their creativity, the higher the chances of realizing effective learning.Pembelajaran di sekolah saat ini belum bisa efektif dikarenakan kurang terorganisirnya pembelajaran oleh Guru.Penelitian ini bertujuan untuk mengetahui pengaruh kreativitas guru Pendidikan Agama Islam di Sekolah Dasar/ Madrasah Ibtidaiyah terhadap pembelajaran efektif. Metode penelitian ini adalah metode kuantitatif dengan pendekatan post-positivisme. Populasi dalam penelitian ini adalah 25 orang guru pendidikan Agama Islam di Sekolah Dasar atau Madrasah Ibtidaiyah di Kota Bandung. Sedangkan sampel nya adalah 18 guru. Pengumpulan data melalui angket. Teknik analisis data menggunakan uji normalitas data dan uji kolerasi. Pengujian hipotesis menggunakan analisis jalur 0,05. Hasil penelitian uji normalitas data menunjukkan data yang berdistribusi normal yang ditujukkan oleh sebaran titik-titik pada diagram Q-Q berada pada garis diagonal baik pada uji kreativitas guru maupun pembelajaran efektif. Hasil uji kolerasi menunjukan terdapat hubungan yang positif antara kreativitas guru terhadap pembelajaran efektif dengan koefesien sebesar 0,522. Kesimpulan dari hasil penelitian ini adalah terdapat pengaruh kreativitas guru dalam usaha mewujudkan pembelajaran efektif. Maka semakin guru Pendidikan Agama Islam meningkatkan kreativitas nya, semakin tinggi peluang untuk mewujudkan pembelajaran yang efektif.
Türkiye’de Enerji Tüketimi, İktisadi Büyüme ve Cari Açık Arasındaki İlişki
Authors: AYHAN Barış , İNANÇLI Selim
Published: December 2022

birbirleri ile ilişkisi ve etkileme düzeyleri incelenmiştir. 1980-2017 yıllarını kapsayan yıllık veriler kullanılarak yapılan analizde iki zaman serisi modeli uygulanmıştır. Zaman serisi modellerinde Türkiye’nin net enerji ithalatçısı olması nedeniyle enerji kullanımında petrolün ve dolayısıyla cari açığın etkisinin yanı sıra GSYH ve enerji tüketimi arasındaki ilişki düzeyi incelenmiştir. Değişkenler arasında uzun dönemli ilişkiler için ilk zaman serisi değişkenlerinden olan GSYH, enerji tüketimini en çok etkileyen değişkendir. GSYH’de %1 düzeyinde bir artış petrol tüketimini %0.691, cari açıkta %1’lik bir artış ise petrol tüketimini %0.066 oranında arttırmaktadır. İkinci zaman serisi modelinde de GSYH’de görülen %1 düzeyinde bir artış toplam enerji tüketimini %0.77, cari açıkta %1 düzeyinde bir artış ise toplam enerji tüketimini %0,012 düzeyinde arttırmaktadır. Modeller sonucunda kısa dönemli ilişkiler de bulunmaktadır. İlk zaman serisi modelinde hata terimi adaptasyon katsayısı -0.268 çıkmaktadır. Bu uzun dönemde her yıl yaklaşık %26,8 oranında dengeden sapmaları azaltarak dengeye yönelimi sağlamaktadır. İkinci zaman serisi modeli için hata terimi adaptasyon katsayısı -0,413 çıkmaktadır ve uzun dönemde dengeden sapmaları her yıl yaklaşık %41,3 oranında azaltmaktadır. Yine, ilk modelde, GSYH’de görülen %1 düzeyinde bir değişme toplam enerji tüketiminde (petrol) %0,75 artışa yol açmaktadır. İkinci modelde ise bu artış %0,72 düzeyindedir. Her iki modelde de değişkenler arasında nedensellik ilişkisinin olduğu tespit edilmiştir. İlk zaman seri analizinde sadece milli gelir enerji tüketiminin nedeni değildir sonucuna ulaşılmıştır. Diğer değişkenler arasındaki nedensellik ilişkilerinde enerji tüketiminin milli gelirin nedeni olmasının yanı sıra cari açığında nedeni olduğu görülmektedir. Cari açık hem milli gelirin hem de enerji tüketiminin nedeni olduğu tespit edilmiştir. Milli gelir de cari açığın nedeni olduğu sonucuna ulaşılmıştır. İkinci zaman serisinde ise nedensellik ilişkileri daha kısıtlı düzeydedir. Cari açığın milli gelirin nedeni olmamasının yanı sıra enerji tüketimi de cari açığın nedeni değildir.
Extraction from finite adjunct clauses: an investigation of relative clause dependencies in Norwegian
Authors: Bondevik Ingrid , Lohndal Terje
Published: December 2022

Recent experiments have confirmed earlier informal evidence that finite adjuncts are not islands categorically. Specifically, it has been shown that adjuncts are not necessarily islands for all dependency types (Sprouse et al. 2016), and that the island status of an adjunct depends on the type of the adjunct clause in question (Kush et al. 2019; Müller 2019; Bondevik et al. 2021; Nyvad et al. 2022). The current study further explores these questions by testing three different adjunct clause types: Clauses introduced by om ‘if’, fordi ‘because’ and når ‘when’, in a relative clause (rc) dependency in Norwegian. We find that forming an rc-dependency into a finite adjunct in Norwegian overall causes island effects, but that there are fine-grained differences within the category ‘adjunct’. Specifically, we find that fordi ‘because’ and når ‘when’ yield large island effects, while om ‘if’, on a par with Kobzeva et al. (2022) and Nyvad et al. (2022), yields intermediate results. Rather than relying on binary distinctions only, we argue that any theory that is to explain the empirical landscape must be sufficiently fine-grained and allow for gradient distinctions.
Technique proposal and application for risk assessment in collective basic sanitation system in rural areas
Authors: Bezerra Nolan Ribeiro , Baracho Rafaella Oliveira , Oliveira Thaynara Lorrayne de , Scalize Paulo Sérgio
Published: December 2022

Nowadays, apply risk assessment processes, from health perspective in all basic sanitation components (water supply, sanitary sewage, solid waste and rainwater management), in order to follow the Resolution 64/292 it is a reality. In this context, this article aimed to propose a risk assessment process (RAP) for collective basic sanitation structures and apply it on a riverside community in Goiás state of Brazil. The steps used included scope definition, technique selection for risk assessment and RAP approach and application. The community studied was Arraial da Ponte, which has collective systems for water supply, solid waste and rainwater management. The selected technique was the probability/consequence matrix, according to the criteria established in NBR IEC/ISO 31010:2021 and proposal included identification stages of RAP risk factors, hazards, contamination route and hazardous events, as well as characterization and risk prioritization. It was based on the components of risk management process of NBR ISO 31000 and on World Health Organization recommendations described for water and sanitary sewage safety plan manuals. As result, health risks were identified in all basic sanitation components, with levels ranging from moderate to unacceptable. The risks showed need for greater attention from managers, as effective public policies implementation. Finally, the RAP managed to prioritize hazardous events and their associated risks, being able to help in the construction of plans and investments in the evaluated community.
Impacts of the Port Activities in Guarujá-SP, Brazil: Biological Monitoring as a Tool for the Assessment of Atmospheric Pollution
Authors: Lima Liliane Neiva Arruda , Ribeiro Andreza Portella , Rakauskas Felipe , Bollmann Harry Alberto , Theophilo Carolina Yume Sawamura , Aranha Sidnei , Santos Cleiton Jordão
Published: December 2022

Guarujá, a tourist city in Baixada Santista – SP that comprises the left bank of the Port of Santos, which plays a leading role as a lever for the country's economic development. However, because of its intense expansion, the city was surprised by an important logistical bottleneck for the flow of production, which generates intense congestion in the streets close to the port area. The lack of fluidity in traffic culminates in intense emission of gases and particulate matter (PM), resulting in increased of atmospheric pollution. Although the Environmental Company of the State of São Paulo (CETESB) is responsible for monitoring air quality, in Guarujá this monitoring is recent and has only one manual station. Vicente de Carvalho is the neighborhood where Porto is located and where, predominantly, its activities and negotiations take place. The population who lives in the place is around 150,000 inhabitants. Therefore, monitoring by CETESB is not representative of polluting activities. This research presents the concentrations of heavy metals that were determined, by an alternative method, which uses plants as bioindicators of pollution. Cadmium is a metal that is commonly present in the composition of diesel. Its concentrations in areas with intense movement of trucks were 155 times greater than those observed in regions without pollution. The diagnosis of pollution carried out in Guarujá has contributed to the understanding of the complexity of urban environmental problems, providing SEMAM with inputs for the formulation of public policies aimed at achieving fairer and more balanced socio-environmental conditions.
Phage DNA extraction with Monarch kit and digestion to single nucleosides v1
Authors: Radkov Atanas
Published: December 2022

This protocol details high-molecular-weight DNA extraction from bacteriophages using the NEB Monarch HMW DNA Extraction Kit for Tissue. Following DNA extraction, DNA is digested down to single nucleosides using the NEB Nucleoside Digestion Mix.
Nucleoside analysis with high performance liquid chromatography (HPLC) v1
Authors: Radkov Atanas
Published: December 2022

This protocol details the detection of modified nucleosides using HPLC.
Mental health, mobility and climate change: a scoping review protocol v1
Authors: Marc Goudet Jean
Published: December 2022

Objective: This scoping review aims to map the knowledge gap on mental health – mobilities – climate change nexus. This will allow us to better understand how people cope with their mental health outcomes in a context of a changing climate and their (im)mobilities. Introduction: Mental health related to climate change and (im)mobilities is an emerging field. If more knowledge has been cumulated on the climate change – migration and physical health nexus, there is still a lack of evidence on the relationship between mental health – climate change – mobilities, especially in the case of slow-onset events. Some researchers perceived mobility as an opportunity to adapt to environmental changes as well as a risk factor for developing mental health issues.The underlying causal pathways are yet to be clarified to include the diversity of mobility (seasonal, immobility, planned, constraints, etc.) related to environmental change and their mental health impacts. Inclusion criteria: Inclusion criteria for papers would be: 1) All types of papers: peer-reviewed, non-reviewed, comments and grey literature; 2) focused on the nexus of mental health – climate change – (im)mobilities; 3) published in English, French, Spanish and Bengali; and 4) publishedfrom the 1st January of 2000 to the 31stof August 2022 which correspond to the most prolific period of publication related to our subject.All papers that do not meet the inclusion criteria will be excluded. Methods: We will conduct a review from three academic search engines (PubMed, WebofSciences, Dimensions.ai) and add manually papers from grey literature, blogs and comments. We will follow the JBI recommendations to select, extract and analyse the evidence based on a thematic approach with the Mixed-Method Appraisal Tool. Three academic databases will be searched. Grey literature, blogs and comment will be added manually.
Phage DNA extraction with phenol-chloroform and digestion to single nucleosides v1
Authors: Borges Adair
Published: December 2022

This protocol details high-molecular-weight DNA extraction from bacteriophages using phenol-chloroform. Following DNA extraction, DNA is digested down to single nucleosides using the NEB Nucleoside Digestion Mix.
Protocol collection: Phage DNA isolation and chemical analysis v1
Authors: Borges Adair
Published: December 2022

Bacteriophages (phages) are viruses that infect bacteria. Some phages chemically modify their genomes to protect them from degradation by bacterial immune systems. We can detect phage genome modifications with mass spectrometry (MS) and high-performance liquid chromatography (HPLC) of phage nucleosides. This collection contains protocols for the entire process: phage growth and concentration, DNA extraction, and chemical analysis of phage nucleosides. We optimized these protocols using E. coli phage T4 and B. subtilis phage SPO1.
Nucleoside analysis with liquid chromatography–tandem mass spectrometry (LC–MS/MS) v1
Authors: Thuy-Boun Peter
Published: December 2022

This protocol details the detection of modified nucleosides using LC–MS/MS
Воздействие компьютерных игр с научно-фантастическим сюжетом на восприятие геймера (на примере Stray)
Authors:   Санкт-Петербургский государственный университет, Балакирева Т.А.
Published: December 2022

Автор исследует воздействие компьютерных игр на восприятие геймера на примере научно-фантастической игры Stray. Современная цифровая культура помимо феноменов цифрового искусства дарит обывателю обилие информации, что делает еще более актуальным концепт страха будущего Э. Тоффлера. Современный геймер, находясь в условиях потребления большого количества информации, испытывает прогностический кризис. Исследование делит воздействие фантастических компьютерных игр на два уровня: поверхностный и глубинный. На поверхностном уровне геймер знакомится с сюжетом игры как с одной из вариаций развития будущего, адаптируется к нему и бессознательно балансирует между верой и неверием в описываемое. На глубинном уровне же происходит трансформация его рефлексии: встреча с фантастическим, а значит, не-сущим, позволяет ему получить опыт взаимодействия с кардинально Другим. Это, в свою очередь, приводит к рефлексии о вопросах социокультурной динамики, что, в общем и целом, повышает уровень его рефлексивного отношения как к происходящему вокруг, так и к собственным переживаниям. С этой целью представляется важной интеграция игр с фантастическим сюжетом в образовательный процесс, что позволит как повысить мотивацию к освоению новой информации, так и в перспективе повлиять на уровень рефлексивного отношения обучающегося.
Цифровизация и другие современные тенденции в области развития игровых технологий в культурно-просветительской деятельности детских библиотек
Authors:   Детская библиотека Павловска, Киселева М.А. ,   Санкт-Петербургский государственный институт культуры
Published: December 2022

В статье затрагивается тема применения игровых технологий в культурно-просветительской деятельности детских библиотек, их действенность и результативность, также раскрываются психологические аспекты, объясняющие и доказывающие целесообразность применения игровых технологий в работе с детской аудиторией. В статье предпринята попытка обозначить наиболее перспективные тенденции в области развития этого направления деятельности как эффективного средства обучения и воспитания подрастающего поколения. Статья раскрывает содержание понятий «эдьютейнтмент», «геймификация» и «диджитализация», которые являются актуальными векторами совершенствования библиотечно-информационной деятельности в области использования игровых технологий. Значительное внимание в статье уделяется именно тенденции диджитализации обучения и процессу цифровизации игровых обучающих технологий, а именно — использованию образовательных интернет-платформ, разработке электронных игр и мобильных приложений, в том числе на примере деятельности детской библиотеки города Павловска, Санкт-Петербург. Цифровизация игровых технологий, применяемых в культурно-просветительской деятельности детских библиотек, определяется автором как направление, которое позволит современным детским библиотекам быть в тренде, стать ближе к читателю и расширить арсенал средств и инструментов, способствующих повышению имиджа детской библиотеки как социокультурного института.
Assessment of metabolic activity and energy supply of peripheral blood lymphocytes
Authors: Zubatkina Ol'ga V. , Dobrodeeva Lilija K. , Samodova Anna V. , Kruglov Sergej D.
Published: December 2022

BACKGROUND: T-cells have the capability to change their metabolism in response to activation signals. Resting T-cells primarily use the oxidation of higher fatty acids and oxidative phosphorylation in mitochondria for their energy needs, whereas activated T-cells switch to aerobic glycolysis and glutaminolysis, using glucose, and glutamine as substrates, respectively.
AIM: To determine the metabolic activity and energy supply of peripheral blood lymphocytes in predominantly healthy northerners by measuring the intracellular content of HIF-1 (hypoxia-induced factor 1), SIRT3 (sirtuin 3), and ATP (adenosine triphosphate).
MATERIALS AND METHODS: 39 volunteers, residents of the Arkhangelsk region (23 women and 16 men, 2362 years old), were selected, and examined for this experiment. We established the total number of peripheral blood lymphocytes with CD-typing of lymphocytes (CD3+, CD4+, CD8+, CD71+) by indirect immunoperoxidase reactions, the content of HIF-1 and SIRT3 in the lymphocyte lysate employing enzyme immunoassay, the concentration of ATP by luminescent analysis through luciferin-luciferase reaction. Statistical analysis was conducted in "Statistica 10.0", cluster analysis was applied using the k-means method. Mean values (M) and standard deviations (SD) were calculated, the normal distribution was tested by the KolmogorovSmirnov and Lilliefors criterion. Student's t-test was calculated, and the differences were considered statistically significant at p 0.05.
RESULTS: The study revealed that the metabolic activity of lymphocytes associated with HIF-1 regulation differs significantly in the examined volunteers,, while in the group with a lower total number of lymphocytes and their subpopulations (CD3+, CD4+, CD8+, CD71+) there is a predominant glycolytic orientation of metabolism with proliferated cells energy supply.
CONCLUSION: Metabolic activity which can be determined by the HIF-1/SIRT3 ratio, and the energy supply of lymphocytes have a substantial impact on their differentiation, proliferation, and functioning.
Physical development comparative study among aborigines inhabiting different regions of Russia’s Northeast
Authors: Averyanova Inessa V.
Published: December 2022

BACKGROUND: Adaptation to climatic conditions influences the main characteristics of subjective physical development and morphofunctional state. These characteristics tend to differ in different geographical regions of northeast Russia.
AIMS: A comparative analysis of basic somatometric indicators was conducted to identify differences between representatives of Magadan Region and Chukotka Autonomous District.
MATERIAL AND METHODS: One hundred and ninety-eight young men aged 1721 years old (Koryaks and Evens) from Magadan Region (the City of Magadan) and 87 young men (Chukchi) aged 1721 years old from Chukotka Autonomous District (the City of Anadyr) participated in this study. Chest circumference was measured, and body mass index and body area were calculated by using the length and weight of the body. The strength of the physique was estimated by applying the Pinier index, and the total body fat content in the two groups was determined.
RESULTS: Somatometric indicators exhibited by modern young male aborigines inhabiting different regions of the Far East demonstrated no significant differences between groups. However, relative to that to that of their peers in previous years, the subjective overall body size of the analyzed samples from the two regions had increased (body length: by 7.7 cm in the Chukotka Autonomous Okrug and 6.5 cm in the Magadan Region; body weight: by 3.7 kg in the Chukotka Autonomous Okrug and by 4.4 kg in the Magadan Region).
CONCLUSION: Aborigines from Magadan Region and Chukotka Autonomous District developed morphotypes with accelerated variables. The changes observed were not dependent on the region of residence or ethnicity.
Advantages and disadvantages of endoscopic sleeve gastroplasty versus laparoscopic sleeve gastrectomy
Authors: Siddiqui Mohammad , Almajrashi Shaker , Alahmre Ali , Alshehri Mohammed , Altowairqi Musab , Alshammari Saad , Maghlooth Faisal Al , Alsaud Sajidah Abu , Alodhaybi Ghadah , Waznah Samar , Thuwaybi Abdullatif Al , Alotaibi Fahad , Siddiqui Moaz
Published: December 2022

Obesity and its associated comorbidities, such as diabetes mellitus, hypertension, and cardiovascular disease, are one of today's most pressing health issues and increasing incidence of obesity has marked it a global health challenge. For obese individuals with a high risk of morbidity and mortality who have not lost enough weight with lifestyle and medicinal care and who are experiencing the repercussions of obesity, bariatric surgery should be taken into consideration. Significant weight loss, the remission of coexisting diseases, and an improvement in quality of life are all possible outcomes of bariatric surgery. Laparoscopic procedures account for 96% of all bariatric procedures performed globally, with laparoscopic sleeve gastrectomy (LSG) being the most popular and prevalent. The current gold standard for bariatric surgery is LSG, since it is associated with significant complications such as gastroesophageal reflux disease hence a less invasive replacement for LSG was developed, which is endoscopic sleeve gastroplasty (ESG). In the past few years, ESG, a relatively new technique of endoscopic bariatric therapy, has become more well-known. Several multi-center studies have established the safety, viability, repeatability, and potential for reversibility of ESG. Although it is inferior to LSG in terms of percentage of total body weight loss (TBWL), but within a year of follow-up, it carries a reduced risk of unfavourable outcomes than other surgical procedures. The purpose of this research is to review the available information about advantages and disadvantages of ESG versus LSG.
An overview of dentin conditioning and its effect on bond strength
Authors: Aljifan Mohammad K. , Alshehri Ahmad M. , Alharbi Reham M. , Al Alhareth Mohammed S. , Alharbi Zakiyah A. , Alamri Samirah M. , Alshahrani Nawaf S. , Alyamani Almuayyad E. , Alzahrani Abdulrahman A. , Alqarni Abdulkarim A. , Al Joaithen Meznah S.
Published: December 2022

Given the inherent qualities of this medium, particularly when contrasted to enamel bonding, bonding to dentin is considered to be a less dependable approach. Further, when dentin is reduced, a sizable amount of cutting detritus coats the dentin's exterior, forming the smear layer. A steep decrease in interfacial adhesion over time has been attributed to the collagen web's inadequate resin impregnation as a result of the dentinal surface preparation with strong acidic agents like phosphoric acid, which left a zone of vulnerable collagen at the root of the hybrid smear layer. Self-etching priming agents that comprise acidic, non-cleansing, polymerizing monomers cause demineralization of the surface and encapsulate the collagen fibers and hydroxyapatite crystals while dissolving the smear layer or incorporating it into the adhesion interface. The concurrent occurrence of dentinal demineralization and monomeric penetration prevents collagen from buckling and shields an exposed collagen web. There may be a drawback to including the smear layer in the hybrid layer, according to certain investigations. Adhesion issues could arise even though the smear layer is reinforced with impregnated resin. To achieve dependable, robust resin-dentin connections, such defects may need to be removed by integrating a distinct etching process because they can reduce the resistance and longevity of the conjugated smear layer. In relation to a traditional bonding system, is has been discovered that removing the smear layer with 0.5 M ethylene diamine tetra-acetic acid (EDTA) before applying a self-etching primer result in greater bond strengths. Even though this approach integrates the smear layer within the adhesion interface, the pre-conditioning of dentin with just an acidic primer is highly convincing and merits additional exploration for the streamlined total-etching systems.
An overview of inflammatory breast cancer
Authors: Siddiqui Mohammad , Alsarhan Mustafa , Almutairi Faisal , Salman Ahmed , Alroudan Dhari , Alotaibi Saleem , Alomran Abdullah , Awaji Taghreed , Buarish Sadaf , Aldahlawi Raghad , Wali Nizar , Siddiqui Malaz
Published: December 2022

Inflammatory breast cancer is an uncommon and severe malignancy that frequently goes undiagnosed at first because it presents similarly to more benign breast diseases like mastitis, resulting in delayed treatment. Inflammatory breast cancer affects 1% to 5% of all occurrences of breast cancer and accounts for 8% to 10% of all breast cancer-related deaths. Erythema, skin abnormalities, nipple inversion, edema, and warmth of the affected breast are all signs of inflammatory breast cancer. Recognized risk factors for inflammatory breast cancer include young age at the time of diagnosis, obesity and African American ethnicity. Rapid onset within 3 months and pathologic evidence of invasive carcinoma leads to diagnosis of disease further including erythema occupying at least one-third of the breast, tumour may or may not be present in this case. Chemotherapy, surgery, and radiation make up the trimodal therapy used to treat inflammatory breast cancer. A modified radical mastectomy performed as part of an aggressive surgical strategy improves survival rates. Although patients with inflammatory breast cancer have worse outcomes than those with noninflammatory breast cancer, those who complete trimodal therapy have a positive locoregional control rate, highlighting the significance of an early diagnosis. Physicians must be aware and examine any clinical manifestation of inflammatory breast cancer if present to make a prompt diagnosis and refer patient for expert care timely also awareness and cancer screening can help in prevention of disease. The purpose of this research is to review the available information about an overview of inflammatory breast cancer.
Comparison between color stability of zirconia and lithium disilicate
Authors: Alfaer Ali S. , Hamdi Bassam A. , Melibary Raghad T. , Alfwais Ryan H. , Asirri Naif M. , Darweesh Rawa A. , Albazi Lateefa M. , Alalawi Faten H. , Asiri Abdulaziz M. , Alshehri Hassan A. , Albuqayli Asrar S.
Published: December 2022

The most widely used glass-ceramic is lithium disilicate (LD) because of its remarkable optical qualities, high strength, and simplicity of manufacture. Greater marginal strength, reduced porosity, and net-shaped manufacturing by pressing are further benefits of LD. The development of yttrium stabilized trigonal zirconia polycrystalline (Y-TZP) ceramics is the result of the pursuit for a material with both mechanical capabilities, like the resistance provided by metallic restoration, and the distinctive optical characteristics of glass-ceramic. The main drawback is the fragile veneering ceramics, which are prone to chipping, debonding, and breakage. There is evidence that extrinsic variables such beverages, mouthwashes, acid solutions, dental brushing, and increased temperatures might cause ceramic surfaces to deteriorate. The composition and surface shape of ceramic materials have an impact on the extrinsic pigment absorption or adsorption from the oral cavity. The main causes for the clinical replacement of anterior restorations, according to prior research, are poor color matching and color instabilities. Monolithic zirconia is more prone to staining from chlorhexidine, green tea, and coffee. In monolithic zirconia, the aging-related color changes are more pronounced. The color of the background substructure influences how zirconia restorations look overall. In terms of color stability and translucency, LD ceramic has also been proven to be more aesthetically pleasing. In comparison to monolithic zirconia, bilayer zirconia with feldspar veneering ceramic displayed reduced discoloration overall. It has been noted that monolithic zirconia is more susceptible to low-temperature degradation than the core Y-TZP. The use of current literature to infer outcomes has several limitations because in most vitro investigations, thermocycling has been carried out in water rather than oral cavity saliva and the influence of sunlight exposure, salivary proteins, food coloring, tobacco, different enzymes, and surface-related factors on the color stability is yet to be examined.
Etiology, risk factors and complications of exercise induced muscle injury
Authors: Sunbol Khalid M. , Althiyabi Fahad S. , Alshuria Abdulaziz A. , Alajwad Mahdi H. , Mahlawi Amoudi M. , Alsayed Budur H. , Alsarhan Mustafa O. , Alshehri Rahaf A. , Alsahli Abdulaziz A. , Alhazmi Khalid A. , Esmae Emtenan A.
Published: December 2022

Healthy lifestyle includes physical activity as the basic component however, exercises with eccentricity have been associated to a higher risk of muscle injury and slower recovery. The development of exercise-induced muscle injury is a phenomenon that results from atypical or unaccustomed activity; the intensity of the pain and the extent of the damage steadily deteriorate over time, and when the exercise session contains an eccentric component, they may last for several days. Increasing levels of muscle-specific circulating protein are present, along with increased levels of muscular pain and decreased muscle strength. The extent of severity of the symptoms following eccentric exercise varies greatly. Exercise-induced muscle injury is influenced by a number of factors including intensity, duration, mode, muscle group, age, gender, genetics, and dietary state. Numerous scientific studies illustrate the circumstances under which exercise causes muscle injury. It is widely acknowledged that exercise that is unfamiliar, particularly exercise that involves eccentric contractions, causes damage. exercise-induced muscle injury is accompanied by an inflammatory response involving numerous mediators, including the production of muscle-specific creatine kinase and interleukins and interleukins receptor antagonist and acute phase proteins. Complications of exercise-induced muscle injury include temporary muscle inflammation, loss of strength, muscle discomfort, restricted range of motion, elevated passive tension, discomfort, and a momentary decline in insulin sensitivity and can also lead to rhabdomyolysis. The purpose of this research is to review the available information about an etiology, risk factors and complications of exercise-induced muscle injury.