bluuebunny/crossref_metadata_2025 huggingface dataset:
An ANN-assisted efficient enriched finite element method via the selective enrichment of moment fitting
Authors: Lee Semin , Kang Taehun , Jung Im Doo , Ji Wooseok , Chung Hayoung
Published: December 2022

Enrichment techniques that employ nonconforming mesh are effective in modeling structures with discontinuities because numerical issues regarding mesh quality are avoided. However, the accurate integration of the bilinear and linear forms on the discretized domain, which is required in the standard Galerkin-based finite element method, is computationally expensive due to the complexity of the enriched basis function. In this paper, we present a fast and accurate alternative method of numerical integration using nonlinear regression enabled by a multi-perceptron feedforward neural network. The relationship between an implicitly represented geometry and the quadrature rule derived from the moment fitting method is predicted by the neural network; the neural network-based regression model circumvents complex computation and significantly reduces the overall online time by avoiding expensive function evaluations. Through the selected numerical examples, we demonstrate the efficiency and accuracy of the current method, as well as the flexibility of the trained network to be used in different contexts.
CUX1-related neurodevelopmental disorder: Deep insights into phenotype-genotype spectrum and underlying pathology
Authors: Oppermann Henry , Marcos-Grañeda Elia , Weiss Linnea , Gurnett Christina , Jelsig Anne Marie , Vineke Susanne , Isidor Bertrand , Mercier Sandra , Magnussen Kari , Zacher Pia , Hashim Mona , Pagnamenta Alistair , Race Simone , Srivast Siddharth , Frazier Zoë , Maiwald Robert , Pergande Matthias , Milani Donatella , Rinelli Martina , Levy Jonathan , Krey Ilona , Fontana Paolo , Lonardo Fortunato , Riley Stephanie , Kretzer Jasmine , Rankin Julia , Reis Linda , Semina Elena , Reuter Miriam , Scherer Stephen , Iascone Maria , Weis Denisa , Fagerberg Christina , Brasch-Andersen Charlotte , Hansen Lars , Kuechler Alma , Noble Nathan , Gardham Alice , Tenney Jessica , Rathore Geetanjali , Beck-Woedl Stefanie , Haack Tobias , Pavlidou Despina , Atallah Isis , Vodopiutz Julia , Janecke Andreas , Lemke Johannes , Jamra Rami Abou , Nieto Marta , Tümer Zeynep , Platzer Konrad
Published: December 2022

Heterozygous, pathogenic CUX1 variants are associated with global developmental delay or intellectual disability. This study delineates the clinical presentation in an extended cohort and investigates the molecular mechanism underlying the disorder in a Cux1+/− mouse model. Through international collaboration, we assembled the phenotypic and molecular information for 34 individuals (23 unpublished cases). A Cux1+/− mouse model was used to analyze CUX1 expression in the brain and evaluate susceptibility to epilepsy. We describe 34 patients with 26 different null and four missense variants. The leading symptoms were mild to moderate delayed speech and motor development, and intellectual disability. In Cux1+/− mice, we found delayed growth, histologically normal brains, and increased susceptibility to seizures. In Cux1+/− brains, the expression of Cux1 transcripts was half of WT animals. Expression of CUX1 proteins was also reduced, although in early postnatal animals significantly more than in adults. In summary, disease-causing CUX1 variants result in a non-syndromic phenotype of developmental delay and intellectual disability. In some patients, this phenotype ameliorates with age, resulting in a clinical catch-up and normal IQ in adulthood. Furthermore, the balance of CUX1 isoform expression in the brain during development appears to be important for this favorable clinical course.
Die Entsperrung und Spiegelung von passwortgeschützten Datenträgern im Siegelungsverfahren
Authors: Reimann Martin
Published: December 2022

Mit seinem Urteil BGE 148 IV 221 hat das Bundesgericht die Praxis der Beschwerdekammer des Bundesstrafgerichts, wonach die Entsperrung und Spiegelung passwortgeschützter Datenträger im Rahmen eines Siegelungsverfahrens durch die Untersuchungsbehörde vorgenommen bzw. an die Forensikabteilung des Bundesamtes für Polizei (fedpol) delegiert werden kann, für bundesrechtswidrig erklärt. Auch wenn der Entscheid des Bundesgerichts im Ergebnis nicht zu beanstanden ist, wirft er mit Bezug auf künftige Siegelungsverfahren verschiedene Fragen auf, die im vorliegenden Beitrag im Anschluss an eine Zusammenfassung der bundesgerichtlichen Erwägungen erörtert werden.

--

Dans son arrêt ATF 148 IV 221, le Tribunal fédéral a déclaré contraire au droit fédéral la pratique de la Cour des plaintes du Tribunal pénal fédéral selon laquelle l'autorité d'instruction peut, dans le cadre d'une procédure d'apposition de scellés, procéder à la copie-miroir de supports de données protégés par un mot de passe ou déléguer ces tâches à la division forensique de l'Office fédéral de la police (fedpol). Bien que le résultat de cette décision ne soit pas critiquable, elle soulève plusieurs questions en ce qui concerne les futures procédures de scellés. Ces questions sont abordées dans cet article, après un résumé des considérants de l'arrêt.
Influence of Preharvest Bagging on Maturity Indices and Postharvest Quality of Cherry Tomato (Solanum lycopersicum var. cerasiforme)
Authors: Buthelezi Nana Millicent Duduzile , Olowoyo Joshua Oluwole , Mafeo Tieho Paulus
Published: December 2022

The production of cherry tomato (Solanum lycopersicum var. cerasiforme) is negatively affected by harsh environmental conditions such as extremely high and low temperatures, wind and hail damage, and pest and disease infestation. These factors delay maturity and cause uneven ripening, fruit abrasion, and blemishes, which consequently result in poor fruit quality and reduced shelf life. Preharvest bagging is an environmentally friendly alternative technique for enhancement of fruit quality and hence alleviates the stated problems. The study evaluated the physico-chemical quality of ‘Tinker’ and ‘Roma VF’ cherry tomato as influenced by preharvest bagging (transparent and blue plastics) during 8 days of shelf life at ambient conditions. Five clusters of fruit per plant per cultivar with a diameter of 1.5 to 2.0 cm were bagged after 16 days of fruit set and harvested at the green maturity stage, 12 days after preharvest bagging for the assessment of postharvest quality. Preharvest bagging effectively accelerated fruit maturity and ripening as indicated by enhanced fruit size, uniform color development, high pH, dry matter (DM) content, soluble solid content (SSC), and low titratable acidity (TA) during shelf life. Bagged fruit had higher loss of firmness and weight mainly due to ripening and showed very slight incidence of diseases during shelf life of 8 days. Unbagged cherry tomato had delayed maturity and ripening; small-sized fruit; uneven color development; low pH, SSC, and DM; and high TA. Although unbagged cherry tomato had lower firmness and weight loss due to delayed ripening, fruit showed moderate to severe incidence of tomato bacterial canker disease (Clavibacter michiganensis subsp. michiganensis) during shelf life. These results indicated that preharvest bagging accelerated fruit maturity and ripening, improved physico-chemical quality, and reduced disease infestation on cherry tomato during shelf life.
Cercospora Leaf Spot Resistance of Crapemyrtle Cultivars in Tennessee
Authors: Parajuli Madhav , Liyanapathiranage Prabha , Shreckhise Jacob , Fare Donna , Moore Benjamin , Baysal-Gurel Fulya
Published: December 2022

Crapemyrtle (Lagerstroemia sp.) is a top-selling deciduous flowering tree in the United States, and its salability is often compromised by cercospora (Cercospora lythracearum Heald & F. A. Wolf) leaf spot. To compare cercospora leaf spot resistance, 32 crapemyrtle cultivars belonging to Lagerstroemia indica, Lagerstroemia fauriei, L. indica × L. fauriei, and L. indica × L. fauriei × Lagerstroemia limii and 12 cultivars or unnamed selections belonging to L. indica, L. indica × L. fauriei, L indica × L. fauriei × L. limii, L. limii, and Lagerstroemia subcostata were planted in field plots in 2004 and 2011, respectively. The experiment was a completely randomized block design with three and four replications in the 2004 and 2011 plantings, respectively. Plants were evaluated for cercospora leaf spot disease severity and defoliation using a scale of 0% to 100% foliage affected from August to October of 2015, 2016, and 2017. Area under the disease progress curve (AUDPC) was calculated for the evaluation period of each year. L. fauriei cultivars Fantasy, Kiowa, Townhouse, and Woodlander’s Chocolate Soldier and L. indica × L. fauriei Apalachee from the 2004 planting, and the L. subcostata and L. limii selections from the 2011 planting had lowest cercospora leaf spot disease severity ratings, AUDPC, and defoliation. L. indica × L. fauriei cultivars Choctaw, Miami, Natchez, Osage, Sarah’s Favorite, Tonto, Tuscarora, and Tuskegee, and L. indica × L. fauriei × L. limii Arapaho were moderately resistant to cercospora leaf spot, whereas cultivars belonging to L. indica and L. indica × L. fauriei × L. limii Cheyenne were highly susceptible to cercospora leaf spot. Results from this research may aid breeders, nursery producers, and landscapers in selecting crapemyrtle species and cultivars with cercospora leaf spot resistance.
Accounting information transparency and business performance: A case of G7 construction companies
Authors: Abbasova Sevinj , Aliyeva Mehriban , Huseynova Leyla
Published: December 2022

A high level of company bankruptcy in certain countries and a low level of profitability actualizes the need to find additional mechanisms for increasing the efficiency of their activities. One of such mechanisms is the growth of information transparency. The study deals with examining the effects of accounting information transparency on business performance on the example of construction companies in G7 countries. The transparency index was used as a parameter characterizing the level of accounting information transparency. The level of business performance was analyzed using the following indicators: value added of the construction industry, investment in the construction industry, number of construction firms, profitability of the construction industry, annual all-work construction output index, and total employees in construction firms. The dependence between the indicators was analyzed using the multiple regression analysis, Dickey-Fuller, Philips Perron, and Johansen tests. According to the results, the most vital link was between the level of accounting information transparency and the volume of investments (increased information transparency by 1 point leads to an increase in the volume of investments from 1.7% to 4.6%). At the same time, the level of accounting information transparency practically does not affect the number of employees (change by 0.1-0.2%) and added value (change by 0.1-0.3%). It was concluded that the policy of accounting information transparency should be an essential element of company strategy aimed to increase the level of its investment attractiveness and confidence of investors and consumers in its activities.
Effect of governance practices on value co-creation and organizational performance: Evidence from village-owned enterprises in Riau, Indonesia
Authors: Nelly Sari Ria , Junita Dewi , Anugerah Rita , Tri Nanda Satria , Zenita Raisya
Published: December 2022

A broader community is currently paying a significant deal of attention to the existence of social enterprises. This is due to the belief that social enterprises can bring answers to community issues. Village-Owned Enterprises (VOEs), as one of the social enterprises that are expected to continue providing sustainable welfare for villages, must always strive for excellent organizational performance to fulfill their objectives. This study is based on the notion of participatory governance; it seeks to evaluate the effect of governance practices on value co-creation, as well as the effect these practices have on organizational performance. This paper collects data utilizing a structured questionnaire and a quantitative research approach. A cluster sampling methodology is used. The respondents are directors of VOEs in Riau Province, Indonesia. One hundred twenty-five data were analyzed using partial least squares (PLS) of the second order. The results reveal that good governance practices will boost value co-creation, enhancing organizational performance. The findings suggest that VOEs should pay particular attention to their process of managing, monitoring, and accountability to achieve value co-creation and fulfill their mission. The uniqueness of this study lies in its investigation of the governance practices of VOEs and the crucial role of value co-creation in enhancing their organizational performance.
AcknowledgmentWe express our gratitude and appreciation to The Directorate of Resources, The Directorate General of Higher Education, The Ministry of Education, Culture, Research and Technology (Ref. 1615/UN.19.5.1.3/PT.01.03/2022) for financial support for this study. We also express the same appreciation to LPPM Universitas Riau for facilitating this research project.
Ocular symptoms of Saul — Wilson syndrome in children
Authors: Kogoleva L. V. , Vorontsova T. N. , Bobrovskaya Ju. A.
Published: December 2022

The genetic Saul — Wilson syndrome is so rare that the very few descriptions of its ocular manifestations available are of high clinical interest. Purpose. To offer a description of the ocular manifestations of the Saul — Wilson syndrome. Material and methods. Two children with a verified diagnosis of Saul — Wilson syndrome, observed from the age of 3 and 4 (the follow-up period was 6 months to 2.5 years), were subjected to a comprehensive ophthalmological examination. Results. The children, along with characteristic phenotypic manifestations (clubfoot, very short stature, short fingers and toes, hypermobile joints) were found to have a disordered visual system, associated with the particularities of the facial skeleton (exophthalmos or strabismus) and clinical and functional eye disorders: mild hypermetropia, hypermetropic astigmatism, partial complicated cataract. One child was diagnosed with changes in the structure and function of the retina, which indicates a dystrophic process. The diagnosis was genetically verified. Conclusion. Given the rarity of the disease, multiple organ involvement, an uncertain prognosis, an interdisciplinary approach to the management of such patients, constant dynamic monitoring and timely correction of detected disorders is necessary.
Long-term results (60 months) of anti-VEGF therapy of macular diseases in real clinical practice. Part 2.
Authors: Bobykin E. V. , Buslaev R. V. , Krokhalev V. Y. , Morozova O. V. , Beresneva N. S.
Published: December 2022

Purpose: to study long-term results of anti-VEGF therapy for macular diseases of patients followed up for 60 months in real clinical practice. Materials and methods. The research group included 57 patients (43 women, 14 men; median age 62 years) who received antiVEGF therapy (ranibizumab, aflibercept) and remained under regular observation for 60 months. Of these, 24 patients had “wet” agerelated macular degeneration (wAMD), 20 had myopic choroidal neovascularization (mCNV), 10 had macular edema due to retinal vein occlusions (MERVO), and 3 patients had diabetic macular edema (DME). Statistical analysis of demographic indicators and treatment results was carried out using STATISTICA 13.3 software: conditions of normality for variables, nonparametric and parametric criteria were determined, and rank analysis of variance was carried out. The characteristics of the study group are given in the first part of this article [ROJ, 2022; 15 (3): 11–17]. Results. Over the research period, the best corrected visual acuity (BCVA) increased from 0.29 0.35 0.42 to 0.47 0.54 0.61 (p < 0.00001); 91.2 % of patients maintained the indicator or improved it with regard to the baseline. The proportion of subjects with BCVA ≥ 0.5 ranged from 61.4 to 73.7 % during the research period. The average number of intravitreal injections (IVI) received by the patients was 8.93 10.84 12.75. We revealed a tendency towards a gradual decrease in the intensity of treatment and confirmed it (p < 0.00001). The proportion of patients who received 4 IVI or more over 12 months of treatment decreased from 57.9 % in the first year to 12.3 % in the fifth year, and the proportion of cases where anti-VEGF therapy did not need to be resumed before the end of the year of treatment increased from 28.1 % (in the second year of research) to 49.1 % (in the fifth year). The need for IVI anti-VEGF drugs in wAMD and DME was significantly greater than in MERVO and mCNV. Conclusion. The results confirm high efficiency of anti-VEGF therapy. To solve the issue of ill-timed or insufficient treatment, it is necessary to start the therapy as early as possible, use the most effective (proactive) regimens, apply individualized approach to the treatment, take organizational measures aimed at facilitation of access to specialized care, and, generally, to change the attitude of the professional community.
Travel Blogs: Genre and Topics
Authors: Olenev Stanislav , Slavnikov Nikita
Published: December 2022

Online travel blogs are a phenomenon of auteur journalism. This article describes the genre specifics of Russian-language travel blogs posted on Youtube video hosting and its development prospects. The new multimedia journalism is highly adaptable, mobile, feasible, and independent. Travel writers used to be limited to a narrow segment of TV channels and magazines; modern travel bloggers develop their own style and do not have to conform to that of the editorial board. The research featured such travel bloggers as Anton Ptushkin, Leonid Pashkovsky, and Anton Lyadov. Each blog proved to be unique it its topics, genres, and methods of presentation, which means that this sector of auteur journalism has a great potential.
Cross-Regional Sentiment Analysis of VKontakte Communities: Typical Krasnodar vs. Typical Kemerovo
Authors: Ryabchenko Natal'ya , Malysheva Ol'ga
Published: December 2022

This research tested a complex analytical method based on semantic modeling of discursive fields and network analysis that can be applied to networked linguistic data. The copyright software package Monitoring and Analysis of Social Networks, Internet Communities, and Users provided automatic data processing to restore the semantic core of the discursive fields generated by Typical Krasnodar and Typical Kemerovo online communities in 2021–2022. The analysis was visualized as social graphs and semantic core models. It identified a number of sensitive topics that generated a lot of feedback. The method also proved efficient in predicting cultural and socio-political trends. The complex methodology provided rapid identification of amplified discursive activity, conditions for social unrest, and bifurcation points for destructive social practices. The results may contribute to effective information management and social strain relief in the regions through discursive control of online communication.
Towards the hydraulics of the hydroinformatics era
Authors: Abbott M.B. , Babovic V.M. , Cunge J.A.
Published: December 2022

Hydroinformatics is the study of the flows of knowledge and data related to the flow of water and all that it transports, together with interactions with both natural and man-made, or artificial, environments (Abbott, 1991). Hydraulics, understood as the study of flows of water, more recently extended to include the transport of matter in all its forms with these flows, is accordingly central to hydroinformatics. Without hydraulics, no hydroinformatics! From this situation it may at first appear as though hydroinformatics provides only a new periphery to hydraulics: a new way of transmitting hydraulics knowledge and data to society. In practice, however, the way in which hydraulics is viewed and practised is itself now changing as a result of its incorporation into the new paradigm that hydroinformatics provides. The first purpose of the present paper is to introduce some of the changes that are currently proceeding in hydraulics under the influence of developments occurring in hydroinformatics. The second purpose is to indicate the consequences of these changes for the application of hydraulics with in society, and thus for the future direction of hydraulics and hydroinformatics themselves.
Preparation of magnetic biochar and its catalytic role in degradation of Cu-EDTA by heterogeneous Fenton reaction
Authors: Jiang Yu , Liu Xinyu , Huang Shikai , Wu Huifang , Liu Haiyan , Liu Shenzhe , Xu Jiale , Wang Kun
Published: December 2022

In this study, magnetic biochar (Fe-BC) was synthesized from phoenix tree leaves and FeSO4·7H2O by impregnation-pyrolysis method, and was used to activate H2O2 to degrade Cu-EDTA. The effects of preparation parameters on the degradation of Cu-EDTA by Fe-BC/H2O2 system were investigated by degradation experiments and characterization methods (SEM, BET, FTIR, XRD and XPS). The results showed that the magnetic biochar prepared under the pyrolysis temperature of 400 °C, pyrolysis time of 3 h and iron content of 3 wt% had the best catalytic activity. Within 120 min, the breaking efficiency of Cu-EDTA binding, precipitation efficiency of Cu2+ and removal efficiency of TOC could reach 78.48, 71.65 and 46.54% at the conditions of adding 1.0 g/L magnetic biochar and 25 mM H2O2 and the iron dissolution was only 0.32 mg/L. The characterization results and comparison experiments demonstrated that the catalytic effect of magnetic biochar not only depends on the transfer of electrons to H2O2 by the loaded iron oxides, but also the active oxygen functional groups (OFGs) and persistent free radicals (PFRs) contained on the surface can transfer electrons to H2O2 or even dissolved oxygen to produce an amount of hydroxyl radicals (·OH) and superoxide anion radicals ().
Desempeño docente percibido por los estudiantes de enfermeria en una Universidad nacional del Callao
Authors: Garcia Matos Lenin Wender
Published: December 2022

Objetivo: Determinar el desempeño docente percibido por los estudiantes de enfermería en una universidad nacional del Callao – 2020. Materiales y métodos: El estudio es de enfoque cuantitativo, descriptivo y transversal, de diseño no experimental. Se contó con una muestra de 166 estudiantes de enfermería de la Universidad Nacional del Callao. La técnica de recolección de datos fue la encuesta y el instrumento de recolección de datos fue el cuestionario CEMEDEPU, el cual está conformado por 48 Ítems y 3 dimensiones. Resultados: Se pudo observar que del 100% (166) de los encuestados, un 42,6% (72) de los participantes refieren un buen desempeño docente, seguido de un 36,1% (61) refieren un desempeño regular, un 18,3% (31) refieren un muy buen desempeño y solo 1,2% (2) refirieron un desempeño deficiente. Respecto a las dimensiones se destacó el nivel bueno en la dimensión centrado en la enseñanza con un 47,9% (n=81). Conclusiones: Se concluye que existe un buen desempeño docente por parte de la plana docente de enfermería.
Alteraciones posturales y su relación con el dolor musculoesquelético en personal de enfermería de un Hospital de Sicuani, Cusco 2022
Authors: Fuentes Rivera Mejía Meyly Reyna
Published: December 2022

Objetivo: Evaluar la relación entre las alteraciones posturales y el nivel de dolor musculoesquelético en el personal de enfermería de un Hospital de Sicuani, Cusco. Materiales y métodos: Estudio transversal, correlacional realizado en una muestra censal de 80 nfermeros asistenciales. Las alteraciones posturales se registraron mediante una ficha de evaluación basado en el Cuestionario Nórdico Estandarizado y el dolor musculoesquelético mediante la escala EVA. Resultados: El 41,3% de las enfermeras presentan dolor intenso. El 45% presenta dolor en la columna. Existe asociación entre las alteraciones las posturales y dolor musculoesquelético (x2 = 14,908, sig. = 0,001). Conclusiones: El hecho de que cualquier alteración postural prolongada en el personal de enfermería, conlleva a los dolores musculoesqueléticos reportados en este estudio y que, siendo así, se proyecta la necesidad de emplear estrategias que provean una solución para la disminución y mejoría de los dolores musculoesqueléticos en este grupo ocupacional.
Actitud ante la responsabilidad ética en estudiantes del posgrado de medicina, UNMSM, 2021
Authors: Izaguirre Sotomayor Manuel , Vera Mendoza Martha , Podestá Gavilano Luis , Huanca Vargas Erika
Published: December 2022

Introducción: La responsabilidad ética, obliga a buscar la excelencia en el profesional de la salud, para prevenir la negligencia o delito, manteniendo las competencias profesionales actualizadas, que le permitan evaluar qué es bueno o malo, que puede o no puede hacer, para brindar una atención de calidad, segura basada en la evidencia científica y ética1. Objetivo: Determinar la actitud hacia la responsabilidad ética de estudiantes del posgrado de la facultad de medicina, UNMSM. Materiales y métodos: Diseño no experimental, Método descriptivo transversal comparativo de enfoque cuantitativo. Instrumento: Cuestionario tipo Escala Likert validado en contenido por juicio de expertos y confiabilidad en una prueba piloto con coeficiente Alfa de Cronbach (0,941). Muestra conformada por 316 estudiantes de posgrado (segunda especialidad, maestrías, doctorados). Análisis de los datos: Se realizó aplicando el análisis de la estadística descriptiva no inferencial, para cada una de las dimensiones. Resultados: El promedio general de la actitud negativa hacia la responsabilidad ética fue de 25,50%, correspondiéndole el mayor puntaje negativo a la dimensión ejercicio profesional (41,50%) y toma de decisiones (36,10%). La actitud indiferente fue mayor en las mujeres que en los hombres en las dimensiones atención médica, toma de decisiones, compromiso moral y ejercicio profesional. Conclusión, en la muestra estudiada, la actitud hacia la responsabilidad ética fue positiva en el 74,42%, e indiferente en el 25,5%, es decir existe el compromiso ético del profesional para cumplir con todo lo que le corresponde en su ejercicio profesional.
Experimental Animal Models: Tools to Investigate Antidiabetic Activity
Authors: Jain Akhlesh Kumar , Madhariya Rashmi , Dixena Bhupendra , Ram Alpana , Vyas Amber
Published: December 2022

About 2.8% of the global population are being suffered from Diabetes mellitus. Diabetes mellitus is a group of metabolic disorders that is characterized by an absolute lack of insulin and resulting in hyperglycemia. To overcome the challenges, many antidiabetic drugs are being used, and research is being carried out in search of more effective anti-diabetic drugs. To study the effectiveness of antidiabetic drugs, many diabetic models, chemicals, and diabetogenic hormones were used at the research level. In this review, we summarised various animal models used, chemicals that induce diabetes, their properties, and the mechanism of action of these models. Further, diabetes mellitus is generally induced in laboratory animals by several methods that include: chemical, surgical and genetic manipulations. To better understand both the pathogenesis and potential therapeutic agents, appropriate animal models of type 1 & type 2 diabetes mellitus are needed. However, for an animal model to have relevance to the study of diabetes, either the characteristics of the animal model should mirror the pathophysiology and natural history of diabetes or the model should develop complications of diabetes with an etiology similar to that of the human condition. There appears to be no single animal model that encompasses all of these characteristics, but there are many that provide very similar characteristics in one or more aspects of diabetes in humans. The use of the appropriate animal model based on these similarities can provide much-needed data on pathophysiological mechanisms operative in human diabetes.
Effectiveness of HM-3-HSA on Inhibiting Cancer Cell Migration and
Metastasis
Authors: Yang Hui , Li Ting , Wang Ruyue , Li Kaike , Wang Peiya , Zhao Jiang , Guo Qi , Zhang Jun , Li Yang , Li Hongyu
Published: December 2022

Background:

Metastasis is the major cause of treatment failure in cancer patients and cancer-associated death, and an antimetastatic drug would be a beneficial therapy for cancer patients. HM-3-HSA is a fusion protein which improved the pharmacokinetics of HM-3 and exerted antitumor and anti-angiogenesis activity in multiple tumor models. However, the efficacy of HM-3-HSA in cancer cell migration and metastasis has not been elucidated.

Materials and methods:

Herein, high-cell density fermentation of Pichiapink strain expressing HM-3-HSA was performed for the first time. Then, the desired protein was purified by Butyl Sepharose High performance, Capto Blue, Phenyl Sepharose 6FF HS and DEAE Sepharose FF. Furthermore, the effect of HM-3-HSA on the migration and invasion of cancer cells was also evaluated, and B16F10 metastasis model was established to detected the anti- metastasis effect of HM-3-HSA in vivo.

Conclusion:

The results indicated that the yield of HM-3-HSA was 320 mg/L in a 10 L fermenter, which was a 46% increase over that expressed in flask cultivation. The desired protein was purified by four-step, which yielded a 40% recovery of a product that had over 99% purity. Purified HM-3-HSA significantly suppressed the migration and invasion of HCT-116, SMMC-7721 and B16F10 cell lines. On the other hand, in the B16F10 metastasis model, HM-3-HSA significantly inhibited pulmonary metastases of B16F10 cells, suggesting that HM-3-HSA exerted the anti-metastasis effect in vivo
Antiviral Activity of Pyrimidine Containing Compounds: Patent Review
Authors: Farghaly Thoraya A. , Harras Marwa F. , Alsaedi Amani M.R. , Thakir Halima A. , Mahmoud Huda K. , Katowah Dina F.
Published: December 2022

Viruses are still the most prevalent infectious pathogens on a worldwide scale, with many
of them causing life-threatening illnesses in humans. Influenza viruses, because of their significant
morbidity and mortality, continue to pose a major threat to human health. According to WHO statistics,
seasonal influenza virus epidemics are predicted to cause over 2 million severe illness cases with
high death rates yearly. The whole world has been suffering from the COVID-19 epidemic for two
years and is still suffering so far, and the deaths from this virus have exceeded three million cases.
Because the great majority of viral infections do not have a specific medication or vaccination, discovering
novel medicines remains a vital task. This review covers reports in the patent literature from
1980 to the end of 2021 on the antiviral activities of pyrimidine moieties. The patent database,
SciFinder, was used to locate patent applications. A large variety of pyrimidine molecules have been
produced and tested for antiviral activity over the last decade. These molecules were reported to inhibit
a wide range of viruses, including influenza virus, respiratory syncytial virus, rhinovirus, dengue
virus, herpes virus, hepatitis B and C, and human immunodeficiency virus. The cytotoxicity of the
developed pyrimidine derivatives was tested in almost all reported studies and the selectivity index
was calculated to show the selectivity and safety of such molecules. From the remarkable activity of
pyrimidine compounds as antivirals for several dangerous viruses, we expect that these derivatives
will be used as potent drugs in the very near future.
A Glimpse at the Quinoline-Hybridization Approach for the Development
of New Antimalarials
Authors: Kaur Sukhbir , Kaur Amanjot , Arora Amandeep , Kumar Vipan
Published: December 2022

One of the most fatal infectious diseases, malaria, still poses a threat to about half of the world's population and is the leading cause of death worldwide. The use of artemisinin-based combination therapy has helped to significantly reduce the number of deaths caused by malaria, but the emergence of drug resistance threatens to undo this gain. In a bid to boost adherence, several new combination therapies with effectiveness against drug-resistant parasites are currently being tested in clinical settings. Nevertheless, notwithstanding these gains, malaria must be completely eradicated by a concerted international effort on several fronts. Quinoline-based compounds were the cornerstone of malaria chemotherapy until recently when resistance to these drugs severely hampered efforts to achieve a "Zero Malaria" world. The inappropriate use of available antimalarials is one of the factors responsible for resistance development and treatment failure, warranting the search for new chemical entities and alternative approaches to combat this threat. A vast number of solutions have emerged and one of them, quinoline-hybridization, is an effective method for introducing structural diversity, resulting in molecules with improved biological activities, reduced drug resistance, fewer drug-drug interactions, and improved safety and pharmacokinetic profiles. Choosing the ideal target combination and achieving a balanced activity toward them while preserving drug-like properties are the key challenges in the development of molecular hybrids. This review examines the highlights of quinoline hybridization, with some of the hybrids exhibiting remarkable in vitro and in vivo activities, emphasizing that it is a useful method for developing new anti-malarial lead compounds.
Recent Excavation of Nanoethosomes in Current Drug Delivery
Authors: Agrawal Aishwarya , Joshi Aalind , Bhattacharya Sankha
Published: December 2022

In the current era, the Transdermal delivery of bioactive molecules has become an area of
research interest. The transdermal route of administration enables direct entry of bioactive molecules
into the systemic circulation with better and easy accessibility, bypassing the hepatic metabolism and
improving patient compliance. Permeation through the skin has always been a barrier. To overcome this
challenge, an efficient route by the vesicular system has been adopted so as to have better skin permeation
of the bioactive molecules. A novel vesicular and non-invasive drug delivery system called Nanoethosomes
was developed. Nanoethosomes are lipid-based vesicular carriers that are used for deeper
permeation of the bioactive agents into the skin. The main components of Nanoethosomes are Phospholipids,
water, and ethanol. High ethanol concentration in Nanoethosomes distinguishes them from other
nano-formulation and results in deeper permeation and smaller vesicular size. This review article gives
detailed information on the formulation techniques, and characterization parameters of nanoethosomes
along with the research work done by various researchers in the same field. The compiled manuscript
gives detailed elaboration about the various drugs used to treat different diseases which when incorporated
in nanoethosomes resulted in better permeability and enhanced bioavailability.
A Multidisciplinary and a Comprehensive Approach to Reducing Fragility
Fractures in Preterm Infants
Authors: Saif Saif Al , Maghoula Mohammad , Babiker Amir , Abanmi Mashael , Nichol Fiona , Al Enazi Modhi , Guevarra Elenor , Sehlie Faisal , Al Shaalan Hesham , Mughal Zulf
Published: December 2022

With advances in neonatal care, bone fractures prior to discharge from the hospital in preterm infants receiving contemporary neonatal care, are rare. Nevertheless, such fractures do oc-cur in very low birth weight and extremely low birth weight infants who go on to develop metabolic bone disease of prematurity (MBDP), with or without secondary hyperparathyroidism. MBDP is a multifactorial disorder arising from the disruption of bone mass accrual due to premature birth, postnatal immobilisation, and loss of placental oestrogen resulting in bone loss, inadequate provi-sion of bone minerals from enteral and parenteral nutrition, and medications that leach out bone minerals from the skeleton. All of these factors lead to skeletal demineralisation and a decrease in bone strength and an increased risk of fractures of the long bones and ribs. Secondary hyperparathy-roidism resulting from phosphate supplements, or enteral/parenteral feeds with a calcium-to-phosphate ratio of < 1.3:1.0 leads to subperiosteal bone resorption, cortical thinning, and further skeletal weakening. Such fractures may occur from routine handling and procedures such as cannu-lation. Most fractures are asymptomatic and often come to light incidentally on radiographs per-formed for other indications. In 2015, we instituted a comprehensive and multidisciplinary Neonatal Bone Health Programme (NBHP), the purpose of which was to reduce fragility fractures in high-risk neonates, by optimising enteral and parenteral nutrition, including maintaining calcium-to-phosphate ratio ≥1.3:1, milligram to milligram, biochemical monitoring of MBDP, safe-handling of at-risk neonates, without compromising passive physiotherapy and skin-to-skin contact with par-ents. The at-risk infants in the programme had radiographs of the torso and limbs at 4 weeks and af-ter 8 weeks from enrolment into the program or before discharge. Following the introduction of the NBHP, the bone fracture incidence reduced from 12.5% to zero over an 18-month period.
The Role of Advanced Technologies against COVID-19: Prevention,
Detection, and Treatments
Authors: Hasanzadeh Elham , Rafati Adele , Tamijani Seyedeh Masoumeh Seyed Hosseini , Rafaiee Raheleh , Golchin Ali , Abasi Mozhgan
Published: December 2022

Concurrent with the global outbreak of COVID-19, the race began among scientists to generate
effective therapeutics for the treatment of COVID-19. In this regard, advanced technology such as nanotechnology,
cell-based therapies, tissue engineering and regenerative medicine, nerve stimulation and
artificial intelligence (AI) are attractive because they can offer new solutions for the prevention, diagnosis
and treatment of COVID-19. Nanotechnology can design rapid and specific tests with high sensitivity for
detecting infection and synthases new drugs and vaccines based on nanomaterials to directly deliver the
intended antiviral agent to the desired site in the body and also provide new surfaces that do not allow
virus adhesion. Mesenchymal stem cells and exosomes secreted from them apply in regenerative medicine
and regulate inflammatory responses. Cell therapy and tissue engineering are combined to repair or
substitute damaged tissues or cells. Tissue engineering using biomaterials, cells, and signaling molecules
can develop new therapeutic and diagnostic platforms and help scientists fight viral diseases. Nerve stimulation
technology can augment body's natural ability to modulate the inflammatory response and inhibit
pro-inflammatory cytokines and consequently suppress cytokine storm. People can access free online
health counseling services through AI and it helps very fast for screening and diagnosis of COVID-19
patients. This study is aimed first to give brief information about COVID-19 and the epidemiology of the
disease. After that, we highlight important developments in the field of advanced technologies relevant to
the prevention, detection, and treatment of the current pandemic.
UJI TOKSISITAS LIMBAH CAIR TAHU TERHADAP HEPAR TIKUS WISTAR (Rattus Norvegicus) SEBAGAI NUTRASETIKAL
Authors: Namira Kusteja Jilan , Nawang Palupi Pratamawari Dyah
Published: December 2022

Latar Belakang: Limbah cair tahu merupakan limbah dengan kandungan isoflavon yang memiliki potensi sebagai nutrasetikal. Dalam pengembangannya, perlu dilakukan uji toksisitas untuk menguji keamanan produk. Hepar merupakan salah satu organ yang berperan aktif dalam detoksifikasi. Tujuan: mengetahui keberadaan efek toksik limbah cair tahu terhadap hepar tikus wistar (Rattus norvegicus) sebagai nutrasetikal. Metode: Penelitian ini menggunakan true experimental in vivo. Sampel berupa hewan coba tikus wistar jantan, dibagi menjadi 6 kelompok kontrol dan kelompok perlakuan yang dibedakan perdosis. Pemberian limbah cair tahu dilakukan selama 28 hari dengan penambahan 14 hari tanpa perlakuan untuk kelompok satelit. Melakukan analisis SGOT dan SGPT. Hasil: pengujian oneway ANOVA menunjukkan bahwa terdapat perbedaan signifikan pada uji SGOT dan SGPT (p<0,05) Kesimpulan: Pemberian limbah cair tahu memberikan perbedaan signifikan di SGOT dan SGPT kelompok dosis 1 dan 3 satelit. Kata kunci: Uji toksisitas, limbah cair tahu, hepar, tikus wistar
KESESUAIAN RADIODIAGNOSIS LESI PERIAPIKAL RADIOLUSEN MENGGUNAKAN SMARTPHONE:CROSS-SECTIONAL STUDY PADA DOKTER GIGI DI JEMBER
Authors: Zaky Narendra Ananda , Prasetyarini Swasthi , Supriyadi Supriyadi
Published: December 2022

Latar Belakang: Salah satu masalah dalam interpretasi dan diagnosis radiografi kedokteran gigi adalah ketidaksesuaian diantara dokter gigi. Penggunaan smartphone diharapkan dapat membantu mengurangi ketidaksesuaian diagnosis radiografi ini. Lesi atau kelainan periapikal adalah lesi pada tulang rahang yang paling banyak ditemukan pada praktik kedokteran gigi. Tujuan: Tujuan penelitian ini adalah untuk mengetahui kesesuaian radiodiagnosis lesi periapikal radiolusen berbasis smartphone oleh dokter gigi di Kabupaten Jember, Indonesia. Metode: Penelitian observasional dengan pendekatan cross sectional ini melibatkan 62 dokter gigi di Kabupaten Jember. Penelitian ini menggunakan 3 radiografi dengan lesi periapikal radiolusen. Instrumen penelitian berupa form diagnosis radiografi. Form diagnosa radiografi dibuat dalam google form dan dibagikan kepada responden melalui aplikasi WhatsApp atau email. Data yang diperoleh dianalisis menggunakan analisis deskriptif. Hasil: Hasil penelitian menunjukkan bahwa kesesuaian radiograf pertama sebesar 75,8%, radiograf kedua sebesar 48,4%, dan radiograf ketiga sebesar 41,9%. Kesesuaian rata-rata diagnosis lesi periapikal radiolusen adalah 55,4%. Kesimpulan: Kesimpulan dari penelitian ini adalah kesesuaian radiodiagnosis lesi periapikal radiolusen berbasis smartphone sebesar 55,4%. Kata kunci: kesesuaian, radiodiagnosis, lesi periapikal radiolusen, smartphone
Ciência e Tecnologia: Percepções de Jovens da Cidade do Rio de Janeiro
Authors: Maria Mendes Ione , Massarani Luisa , Castelfranchi Yurij
Published: December 2022

Muitos dos desafios das democracias contemporâneas estão ligados à circulação, à apropriação social, à discussão e ao uso do conhecimento tecnocientífico. Nesse sentido, estudar percepções sobre a ciência e a tecnologia, atitudes e práticas de apropriação do conhecimento de diversos públicos é hoje um tema central tanto no contexto acadêmico como para gestores, para a construção de indicadores de avaliação e criação de políticas. Nesse contexto, um público se destaca pelas suas particularidades: os jovens com idade entre 18 e 24 anos, que nasceram e cresceram juntos com a internet no Brasil, chegando à vida adulta a partir de uma socialização em que não tiveram papel central apenas a escola e a família, mas também os fluxos de informação e as práticas de sociabilidade em redes online. Com o objetivo de explorar, aprofundar e contextualizar opiniões e percepções destes jovens sobre ciência e tecnologia, realizamos neste estudo, de caráter qualitativo, cinco entrevistas em profundidade, seguidas de cinco grupos de discussão com jovens residentes da cidade do Rio de Janeiro. Coletamos um rico corpus junto a esses jovens que apresentaram uma visão positiva da ciência e tecnologia, reconhecendo seus benefícios e riscos, vinculando a atuação da área ao contexto social e trazendo-nos reflexões e possibilidades para estabelecer diálogos e processos comunicacionais.
Bottom-Up and Reciprocal Citizen Science: Untapped Resources of Novel Ideas. Preliminary Experiences of a Citizen Science As Public Engagement Program
Authors: Hargitai Evelin Gabriella , Sik Attila , Samoczi Alexandra , Hathazi Milan , Bogdán Csaba
Published: December 2022

In scientific research, citizen science is widely regarded as an involvement of the general public in scientific research initiated by universities, scientific organisations or research centres. In this top-down approach (top-down citizen science), participating citizens usually collect data or provide samples for research — that is, they are considered volunteer research assistants following instructions. This study analyses alternatives of top-down citizen science: one, widely known, which is the bottom-up way of citizen science and another, the reciprocal approach suggested by the authors. Bottom-up is based on local initiatives and is constituted by community-led projects. For bottom-up citizen science, scientific organisations may provide methodological and organisational frames. However, the idea and the implementation remain in the competence of the participant citizens. Reciprocal citizen science emerged from a need for a more holistic policy toward citizen science. As part of this, identifying viable citizen-initiated projects, measuring their scientific and/or innovation potential, and integrating them into a citizen science mentor program are questions to be systematically discussed and solved. This study addresses methodological challenges in mentoring citizen science projects, covering a mentor training concept for citizen science designed by the Institute of Transdisciplinary Discoveries. Encouraging citizen research is needed for a new impetus to scientific discoveries. The perspectives of people with no scientific background can also advance problems — mainly those that require fresh and unbiased approaches. Citizen science may also be a solution for leveraging the knowledge of science leavers.
INFORMATION SYSTEMS AS A TOOL FOR IMPROVING THE SEAPORTS PRODUCTIVITY
Authors: Zub I. V. , Ezhov Y. E. , Angolenko T. S.
Published: December 2022

The object of the study is a seaport as a transport hub with an internal infrastructure consisting of various departments whose actions are coordinated by the management system. It is noted that the introduction of information systems into the port management structure allows coordinating actions between port departments and external partners. The seaport is considered as a system consisting of subsystems, information about the state of which allows to streamline the processes of cargo movement, to carry out the activities of the port for a certain planning period and to make decisions in case of non-standard situations. It is noted in the paper that loading and unloading operations in the port are carried out by means of lifting and transport equipment, which has recently been produced with automatic and automated control. Attention is drawn to the fact that automated loading and transport equipment and related technologies for processing and tracking storage locations of processed goods contribute to improving the seaports efficiency. It is emphasized that the use of information technologies in seaports reduces the errors probability that may occur due to the human factor, contributes to the optimization of technological processes and reduces vehicle downtime. It is particularly noted that the development of information systems contributes to the integration of the cargo plan of the seaport with the shift-daily plan and the arrival of vehicles for processing, which allows for the operational management of the seaport. These data indicate that information resources are an economic value and act as one of the factors of seaport management. The information technologies used in the transport industry are considered and trends in the development of information systems of the port economy are identified in the paper. Based on the analysis of literary sources, it is concluded that the introduction of information technologies in ports contributes to increasing productivity and strengthening cooperation between interested parties in the transport sphere of activity. Smart ports will allow the port industry to interact with external enterprises with higher accuracy, openness and transparency, thereby improving relations and efficiency.