Vitamin D status and cholecalciferol supplementation on patients with active Basedow disease: a clinical study
Authors:   ", Nedeltcheva-Petrova Eugeniya ,   1 Department of Endocrinology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania 2 Department of Endocrinology, C.I. Parhon National Institute of Endocrinology, Bucharest, Romania", Ghemigian Mircea ,   Department of Endocrine Surgery, C.I. Parhon National Institute of Endocrinology, Bucharest, Romania, Petrov Boris ,   Department of Gastroenterology, Medica Endoprovision Clinique, Bucharest, Romania, Ghemigian Adina ,   "1 Department of Endocrinology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania 2 Department of Endocrinology, C.I. Parhon National Institute of Endocrinology, Bucharest, Romania", Carsote Mara ,   "1 Department of Endocrinology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania 2 Department of Endocrinology, C.I. Parhon National Institute of Endocrinology, Bucharest, Romania", Sandru Florica ,   "1 Department of Dermatology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania  2 Department of Dermatology, Elias Emergency Hospital, Bucharest, Romania ", Sinescu-Baltateanu Ruxandra D. ,   "Department of Plastic and Reconstructive Surgery, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania  2 Department of Plastic and Reconstructive Surgery, Elias Emergency Hospital, Bucharest, Romania", Filipescu Alexandru ,   "Department of Obstetrics and Gynecology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania  2 Department of Obstetrics and Gynaecology, Elias Emergency Hospital, Bucharest, Romania", Dumitrascu Mihai C. ,   "1 Department of Obstetrics and Gynecology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania  2 Department of Obstetrics and Gynecology, University Emergency Hospital, Bucharest, Romania"
Published: June 2022

This study aims to analyze the 25-hydroxyvitamin D (25OHD) corelations with TRab (anti-TSH receptor Antibodies) at baseline and after corections of 25OHD deficit. Method: Prospective, interventional, controled, single-centre, clinical study on 62 patients with active Basedow disease (BD), admitted at C.I. Parhon National Institute of Endocrinology, Bucharest, Romania, between 2013 and 2020. Patients were divided into two groups: one group (N=37) received 2000 IU of daily cholecalciferol and a second one (N=25) without vitamin D supplementation, all subjects being under anti-thyroid drugs (standard guideline therapy). 25OHD and TRab levels were assessed at start and after 6, respective 12 months. Results: Initial evaluation confirmed vitamin D deficiency (mean 25OHD of 18.33±6.45 ng/mL). At start, TRab negatively correlates with 25OHD (N=62, r= -0.22, p=0.08). The decrease in TRab was statistically significant higher in group 1 versus group 2 after 6 months (35.84% versus 3.53%, p=0.03). After 12 months, TRab decreased with 56.28% in group 1, respective 27.16% in group 2 (p=0.03). In group 1, inverse correlation between 25OHD and TRab was consistent at 6 and 12 months. Conclusion: In patients with active BD, TRab values were negatively correlated with 25OHD at baseline and during follow-up. Correction of vitamin D deficiency is correlated with the decrease of TRab levels.