bluuebunny/crossref_metadata_2025 huggingface dataset:
Bone remodeling around implants placed after socket preservation: a 10-year retrospective radiological study
Authors: Roberto Crespi , Paolo Toti , Giovanni Crespi , Ugo Covani , Bruno Brevi , Giovanni-Battista Menchini-Fabris
Published: July 2021

Background

To evaluate and compare the long-term clinical and radiological outcomes of post-extraction sockets after ridge preservation either with porcine xenograft or collagen alone. Patients underwent single-tooth extraction in the posterior mandible. Fresh extraction sockets were filled with pre-hydrated cortico-cancellous porcine bone or collagen sponge. Two or 3 months later, a ridge expansion technique with immediate implant positioning placement was performed. Primary (alveolar width changes) and secondary outcomes (adverse events and long-term maintenance of buccal plate covering the implant) were evaluated.

Results

Thirty-four women and 20 men were selected: 30 implants (group A) placed into healed post-extraction sockets grafted with porcine bone and 24 (group B) into sockets filled with a collagen sponge. There was a significant loss in width in both groups from the first and second surgery (ranging between 2.7 mm and 4.5 mm). The ridge splitting with bone expansion resulted in significant long-term increases in width for both procedures and implant sites. Non-significant differences in alveolar width were registered between the groups at 10-year follow-up even if the analysis of the implant buccal bone coverage suggested that group A had significantly worst results.

Conclusions

Porcine bone group had significantly better short-term outcomes with lower long-term maintenance of the buccal plate.
Traumatic brain injury and sight loss in military and veteran populations– a review
Authors: Hussain Syeda F. , Raza Zara , Cash Andrew T. G. , Zampieri Thomas , Mazzoli Robert A. , Kardon Randy H. , Gomes Renata S. M.
Published: July 2021

War and combat exposure pose great risks to the vision system. More recently, vision related deficiencies and impairments have become common with the increased use of powerful explosive devices and the subsequent rise in incidence of traumatic brain injury (TBI). Studies have looked at the effects of injury severity, aetiology of injury and the stage at which visual problems become apparent. There was little discrepancy found between the frequencies or types of visual dysfunctions across blast and non-blast related groups, however complete sight loss appeared to occur only in those who had a blast-related injury. Generally, the more severe the injury, the greater the likelihood of specific visual disturbances occurring, and a study found total sight loss to only occur in cases with greater severity. Diagnosis of mild TBI (mTBI) is challenging. Being able to identify a potential TBI via visual symptoms may offer a new avenue for diagnosis.
Recent advances in transdermal drug delivery systems: a review
Authors: Jeong Woo Yeup , Kwon Mina , Choi Hye Eun , Kim Ki Su
Published: July 2021

Various non-invasive administrations have recently emerged as an alternative to conventional needle injections. A transdermal drug delivery system (TDDS) represents the most attractive method among these because of its low rejection rate, excellent ease of administration, and superb convenience and persistence among patients. TDDS could be applicable in not only pharmaceuticals but also in the skin care industry, including cosmetics. Because this method mainly involves local administration, it can prevent local buildup in drug concentration and nonspecific delivery to tissues not targeted by the drug. However, the physicochemical properties of the skin translate to multiple obstacles and restrictions in transdermal delivery, with numerous investigations conducted to overcome these bottlenecks. In this review, we describe the different types of available TDDS methods, along with a critical discussion of the specific advantages and disadvantages, characterization methods, and potential of each method. Progress in research on these alternative methods has established the high efficiency inherent to TDDS, which is expected to find applications in a wide range of fields.
Role of slaughter facilities management in zoonoses and safety of meat produced for human consumption in Nigeria: a review
Authors: Ibrahim Salisu , Kaltungo Bilkisu Yunusa , Uwale Hajara Buhari , Baba Alhassan Yunusa , Saidu Shehu Na-Allah , Mohammed Farouk Umar , Dahiru Hashimu Mohammed
Published: July 2021

Background

This study attempts to review the role of slaughter facilities management of all zoonotic diseases encountered at the abattoirs as well as the safety of meat produced for public consumption in abattoirs in Nigeria. Good hygienic practices were totally absent in the abattoirs. There were dilapidated slaughtering and processing facilities, inadequate clean water supplies, no refrigerators and lack of facilities for the collection and storage of waste. Zoonotic agents demonstrated in slaughtered animals in Nigeria includeMycobacterium tuberculosis,Mycobacterium bovis,Leptospiraspecies,Campylobacterspecies,Yersiniaspecies,Clostridiaspecies.,Brucella abortus, Brucella melitensis, Brucella suis, andSalmonella spp. Other disease-causing infectious agents encountered at the abattoirs includeEcherichia coliO157,SalmonellaandCampylobacterspecies. The meat transportation is done by motor bike, wheel barrows and open vehicles and this become sources of physical contamination.

Main Body

Animals were not being examined regularly before or after slaughter, offals were washed with drainage water, effluent from drainage systems and that meat and organs cleaned from such drainages were sold to the public, leading to unsafe meat being released for public consumption. Meat and carcasses were conveyed out of the abattoir using unhygienic means of transport. Butchers and many abattoir workers were observed not using protective clothing during operations. Waste disposal was indiscriminate not regularly carried out which was hazardous to the environment, while the authorities concerned were not making any effort to improve the situation. Diseases such as Contagious Bovine Pleuropneumonia, Fasciolosis, Tuberculosis and Helminthoses were most frequently encountered some of the diseases were of public health and economic importance.

Conclusion

Meat Inspection and hygiene Act shall be enacted and signed into law. Provision of waste disposal system such as incinerators are recommended. The drainage system should be upgraded and modernized. Use of abattoir waste as a manure and the slurry as fertilizer is also recommended. In Nigeria none of the abattoirs met the minimum hygienic standard of operation as recommended by the Codex Alimentarius and they could not have supported the production of safe meat and meat products for human consumption.
Recent progress in electro-optic polymer for ultra-fast communication
Authors: Ullah Fateh , Deng Niping , Qiu Feng
Published: July 2021

The rocketed development concerning electro-optic polymers fundamentally motivated by its pragmatic application in envisioning second-order nonlinear optics and waveguiding are cardinal. Modern synthetic strategies consigned an outstanding optical quality amorphous polymers with enhanced properties. Documented data revealed a huge progress in understanding their implementation, however challenges still exist regarding their temporal stabilities etc. This review delivers a brief investigation of nonlinear optical (NLO) polymer materials demonstrated over previous decades. Besides, their categorical explanation along with their structural architecting via engineering polymeric backbone or functionalization of the molecular entities have been reviewed. Correspondingly, their temporal and thermal stabilities accompanied by NLO characteristics features are also discussed.
Bioequivalence study of different brands of vildagliptin in healthy human subjects
Authors: Sharma Mahaveer , Agrawal S. S.
Published: July 2021

Background

Vildagliptin is a dipeptidyl peptidase-4 inhibitor used to treat diabetes mellitus. No bioequivalence study data have been published for the Indian population comparing bioequivalence of vildagliptin brands Galvus, Zomelis, and Jalra. This study aimed to evaluate the bioequivalence between three brands of vildagliptin 50 mg tablet (test 1, Zomelis; test 2, Jalra; and reference, Galvus) and to compare these test formulations with the reference formulation to meet the regulatory requirements of bioequivalence of CDSCO, India. The study was conducted in the clinical research center of the college after enrolling 12 healthy volunteers. This study was a single-dose, randomized, open-label, balanced, three treatment, three period, under fasting condition in 12 adult healthy volunteers. After overnight fasting, the subjects received a single dose of either of any three brands of the vildagliptin tablet (T1—test 1; T2—test 2; and R—reference). The washout period was 7 days. Randomization was in the way of T1T2R in the first period, T2T1R in the second period, and RT1T2 in the third period. Blood samples were collected, after that drug concentration in the plasma was measured with the help of HPLC. Outcome measures 90% confidence interval of the geometric mean ratios (test/reference) for the LnCmax, LnAUC0-t, and LnAUC0-∞ was calculated.

Results

The AUC0-t was 1390.03, 1401.50, and 1409.37 ng h/ml for the T1, T2, and R, respectively. Cmax was 287.89, 287.41, and 285.17 ng/ml for the T1, T2, and R, respectively. AUC0-∞ was 1452.03, 1467.59, and 1473.53 ng h/ml for the T1, T2, and R, respectively. No significant difference was observed in the pharmacokinetic parameters between the T1, T2, and R. The geometric mean ratios for T1/R for LnCmax, LnAUC0-t, and LnAUC0-∞ were 1.0014 (90% CI, 1.0002–1.0026), 0.9992 (90% CI, 0.9971–1.0013), and 0.9994 (90% CI, 0.9973–1.0016), respectively. For the T2/R, geometric mean ratios for LnCmax, LnAUC0-t, and LnAUC0-∞ were 1.0003 (90% CI, 0.9992–1.0013), 0.9988 (90% CI, 0.9969–1.0008), and 0.9985 (90% CI, 0.9961–1.0010), respectively.

Conclusion

In this single-dose study involving Indian healthy volunteers under fasting conditions, the three brands of vildagliptin (Zomelis, Jalra, and Galvus) were bioequivalent as per the bioequivalence criterion of CDSCO, India.
The effects of well damage and completion designs on geoelectrical responses in mature wellbore environments
Authors: Beskardes Gungor D. , Weiss Chester J. , Um Evan , Wilt Michael , MacLennan Kris
Published: July 2021

Well integrity is one of the major concerns in long-term geologic storage sites due to the potential risk of well leakage and groundwater contamination. Evaluating changes in electrical responses due to energized steel-cased wells has the potential to quantify and predict possible wellbore failures because any kind of breakage or corrosion along highly conductive well casings will have an impact on the distribution of the subsurface electrical potential. However, realistic wellbore-geoelectrical models that can fully capture fine-scale details of well completion design and the state of well damage at the field scale require extensive computational effort, or they can even be intractable to simulate. To overcome this computational burden while still keeping the model realistic, we have used the hierarchical finite-element method that represents electrical conductivity at each dimensional component (1D edges, 2D planes, and 3D cells) of a tetrahedral mesh. This allows well completion designs with real-life geometric scales and well systems with realistic, detailed, progressive corrosion and damage in our models. We have developed a comparison of possible discretization approaches of a multicasing completion design in the finite-element model. The effects of the surface casing and the coupling between concentric well casings as well as the effects of the degree and the location of well damage on the electrical responses are also examined. Finally, we analyze real surface electric field data to detect wellbore integrity failure associated with damage.
Short-term seasonal changes of the Dzita beach of Ghana using geographic information system and photogrammetry
Authors: Brempong Emmanuel K. , Angnuureng Donatus Bapentire , Appeaning Addo Kwasi , Jayson-Quashigah Philip-Neri
Published: July 2021

Coastal erosion has become an issue globally. As the sea level continues to rise due to global warming, projections are that erosion would increase. To address the issue sustainably, relevant scientific information such as sediment transport and shoreline dynamics is required at local scales. Over the years, erosion at the eastern coast of Ghana has been mainly evaluated using low-resolution imagery due to the challenges in retrieving high-resolution data in the nearshore region. An unmanned aerial vehicle (UAV) approach was used to assess beach evolution on a seasonal and short-term basis between May 2018 and December 2019. Using the UAV approach, shoreline changes, sediment volume changes, and profile elevation parameters were extracted for the Dzita beach of Ghana. Shoreline changes indicated the dominance of erosion during the first and third phases (May 2018–December 2018 and June 2019–December 2019, respectively) at a rate of −7.23 ± 0.23 and −4.85 ± 0.23 m/yr, whereas the second phase (January 2019–June 2019) showed accretion of +8.44 ± 0.23 m/yr. Beach profiles from the first, second, and third phases had steep and gentle slopes, respectively. From these observations, it was recommended that soft engineering approaches such as beach nourishment should be implemented to protect the shoreline and strict prevention of nearshore sand mining and gravel mining. It is also possible that the beach could go through a cycle of changes. Further studies using this same approach should be done as well as probing into other parameters such as nearshore bathymetry to have a better understanding of beach dynamics as envisaged.
Crisis care: tackling the climate and ecological emergency
Authors: Bailey Cate , Poole Norman A. , James Adrian
Published: July 2021

The climate crisis is a health crisis; it demands the urgent attention and action of healthcare professionals and organisations. In this issue of the BJPsych Bulletin, we consider what the destructive effects of the climate and ecological crisis entail for the mental health of populations, and what the response of psychiatrists, both individual and collective, must be. We also highlight the opportunities and benefits a more sustainable and preventative approach could offer individuals, communities and the planet.
Transition to psychosis in randomized clinical trials of individuals at clinical high risk of psychosis compared to observational cohorts: a systematic review and meta-analysis
Authors: Salazar de Pablo Gonzalo , Davies Cathy , de Diego Héctor , Solmi Marco , Shin Jae Il , Carvalho Andre F. , Radua Joaquim , Fusar-Poli Paolo
Published: July 2021

Background

Individuals at clinical high risk of psychosis (CHR-P) recruited in randomized clinical trials (RCTs) and observational cohorts may display a different enrichment and hence risk of transition to psychosis. No meta-analysis has ever addressed this issue.

Methods

“Preferred Reporting Items for Systematic reviews and Meta-Analyses” (PRISMA) and “Meta-analysis Of Observational Studies in Epidemiology” (MOOSE)–compliant meta-analysis. PubMed and Web of Science were searched until November 2020 (PROSPERO:CRD42021229223). We included nonoverlapping longitudinal studies (RCTs-control condition and observational cohorts) reporting the transition to psychosis in CHR-P individuals. The primary effect size measure was the cumulative risk of transition at 0.5, 1, and 2 years follow-up in RCTs compared to observational cohorts. Random effects meta-analyses, heterogeneity assessment, quality assessment, and meta-regressions were conducted.

Results

Ninety-four independent studies (24 RCTs, 70 observational cohorts) and 9,243 individuals (mean age = 20.1 ± 3.0 years; 43.7% females) were included. The meta-analytical risk of transitioning to psychosis from a CHR-P stage was 0.091 (95% confidence intervals [CI] = 0.068–0.121) at 0.5 years, 0.140 (95% CI = 0.101–0.191) at 1 year and 0.165 (95% CI = 0.097–0.267) at 2 years follow-up in RCTs, and 0.081 (95% CI = 0.067–0.099) at 0.5 years, 0.138 (95% CI = 0.114–0.167) at 1 year, and 0.174 (95% CI = 0.156–0.193) at 2 years follow-up in observational cohorts. There were no between-group differences in transition risks (p > 0.05). The proportion of CHR-P individuals with substance use disorders (excluding alcohol and cannabis) was higher in observational cohorts (16.8, 95% CI = 13.3–21.0%) than in RCTs (3.4, 95% CI = 0.8–12.7%; p = 0.018).

Conclusions

There is no meta-analytic evidence supporting sampling biases in RCTs of CHR-P individuals. Further RCTs are needed to detect effective interventions to prevent psychosis in this at-risk group.
Breast Cancer Prevention: Time for Change
Authors: Chlebowski Rowan T. , Aragaki Aaron K. , Pan Kathy
Published: July 2021

Agency breast cancer prevention guidelines for other than hereditary cancers have not materially changed in 20 years; endocrine-targeted agents (then, tamoxifen; now, adding raloxifene and aromatase inhibitors) reduce good prognosis estrogen receptor (ER)–positive, progesterone receptor (PR)–positive cancers without reducing deaths from breast cancer. Across three tamoxifen placebo-controlled prevention trials (N = 23,360) begun almost 30 years ago, although there were 226 fewer breast cancer cases, there were nine more deaths from breast cancer in the tamoxifen groups. Following clinical advances, currently more than half of breast cancer cases are solved problems with extremely low risk of death. As endocrine-targeted agents commonly prevent these cancers, widespread implementation of current prevention strategies may not reduce deaths from breast cancer. Compared with other breast cancers, ER-positive, PR-negative cancers and triple-negative cancers have inferior survival (90.6% v 83.8% v 78.1%, respectively; P < .001). Against this background, in the Women's Health Initiative Dietary Modification randomized trial (N = 48,835), ER-positive, PR-negative cancers were statistically significantly reduced in the intervention group (hazard ratio, 0.77; 95% CI, 0.64 to 0.94) and deaths from breast cancer were reduced 21% ( P = .02). In the Women's Health Initiative randomized, placebo-controlled trial evaluating conjugated equine estrogen (N = 10,739), ER-positive, PR-negative cancers were statistically significantly reduced in the intervention group (hazard ratio, 0.44; 95% CI, 0.27 to 0.74) and deaths from breast cancer were reduced 40% ( P = .04). These findings suggest that reexamination of breast cancer risk reduction strategies and clinical practice is needed.
FGFR Inhibitor Toxicity and Efficacy in Cholangiocarcinoma: Multicenter Single-Institution Cohort Experience
Authors: Gile Jennifer J. , Ou Fang-Shu , Mahipal Amit , Larson Joseph J. , Mody Kabir , Jin Zhaohui , Hubbard Joleen , Halfdanarson Thorvardur , Alberts Steven R. , Jatoi Aminah , McWilliams Robert R. , Ma Wen Wee , Ilyas Sumera , Smoot Rory , Roberts Lewis , Gores Gregory , Borad Mitesh , Bekaii-Saab Tanios S. , Tran Nguyen H.
Published: July 2021

PURPOSE

Cholangiocarcinomas (CCA) are a group of heterogeneous tumors arising from the biliary epithelia. Significant sequencing efforts have provided further insights into the molecular mechanisms of this disease including fibroblast growth factor receptor ( FGFR) alterations, which occurs in approximately 15%-20% of intrahepatic CCAs. Herein, we describe the FGFR inhibitor (FGFRi)-associated treatment toxicity and cancer-specific outcomes from a multicenter single-institution cohort.

METHODS

This is a retrospective study of patients with CCA and known FGFR alterations treated with FGFRi. We describe the toxicity and efficacy in patients treated at Mayo Clinic between January 2010 and December 2020.

RESULTS

Our group identified 61 patients with advanced or metastatic CCA, 19 males (31%) and 42 females (69%), harboring FGFR alterations who received FGFRi. The most common grade 1 or higher adverse events for all patients included fatigue (92%), AST elevations (78%), anemia (80%), decreased platelet count (63%), and hyperphosphatemia (74%). Median progression-free survival on FGFRi was 5.8 months for all patients (95% CI, 4.9 to 9.0). Females had significantly longer progression-free survival at 6.9 months (95% CI, 5.2 to 11.8) on FGFRi compared with males at 4.9 months (95% CI, 2.8 to not estimable; P = .038).

CONCLUSION

FGFRi are well tolerated with clinical efficacy. With the recent approval of FGFRi by the US Food and Drug Administration and ongoing clinical trials for new FGFRi, understanding outcomes and toxicity associated with these medications is important for precision oncology.
Limit on Higgs boson trilinear self-coupling in coupled technicolor models
Authors: Doff A. , Natale A. A.
Published: July 2021

The trilinear self-coupling of the Higgs boson, in a theory in which this boson is composite, is compared to the experimental bound of this quantity obtained by the CMS experiment. In the case of a model where technicolor (TC) is coupled to QCD, we find that the experimental result already constrains the dynamics of the theory, which is represented by an expression of the technifermion self-energy

typical of technicolor coupled models, and function of the dynamically generated technifermion mass and two other parameters that describe the technifermion dynamical mass momentum dependence. The limits imposed on this dynamics allow us to make a simple determination of pseudo-Goldstone boson masses that appear in these theories, indicating that these bosons may be expected to be quite massive.
Regulating Bracero Migration: How National, Regional, and Local Political Considerations Shaped the Bracero Program
Authors: García Alberto
Published: July 2021

This article examines how federal, state, and municipal governments administered the migrant worker selection process in the states of Guanajuato, Jalisco, and Michoacán during the initial phase of the Bracero Program, a bilateral initiative that allowed Mexican men to work in the United States as seasonal contract farmworkers. It argues that multiple political factors—such as the activities of groups that opposed the ruling Partido Revolucionario Institucional, organized labor conflicts, and the need to respond to natural disasters—influenced how officials allocated contracts, which rural workers were deemed eligible or ineligible to migrate, and which individual rural workers ultimately received contracts. The article shows that federal authorities delegated increased administrative responsibilities to state and municipal governments as the Bracero Program progressed, which in turn allowed regional and local officials to exercise considerable influence during selection periods.
Mechanics of the Peripheral Auditory System: Foundations for Embodied Listening Using Dynamic Systems Theory and the Coupling Devices as a Metaphor
Authors: Jactat Bruno
Published: July 2021

Current approaches to listening are built on standard cognitive science, which considers the brain as the locus of all cognitive activity. This work aims to investigate listening as phenomena occurring within a brain, a body (embodiment), and an environment (situatedness). Drawing on insights from physiology, acoustics, and audiology, this essay presents listening as an interdependent brain-body-environment construct grounded in dynamic systems theory.

Coupling, self-organization, and attractors are the central characteristics of dynamic systems. This article reviews the first of these aspects in order to develop a fuller understanding of how embodied auditory perception occurs. It introduces the mind-body problem before reviewing dynamic systems theory and exploring the notion of coupling in human hearing by way of current and original analogies drawn from engineering. It posits that the current use of the Watt governor device as an analogy for coupling is too simplistic to account for the coupling phenomena in the human ear.

In light of this review of the physiological characteristics of the peripheral auditory system, coupling in hearing appears more variegated than originally thought and accounts for the diversity of perception among individuals, a cause for individual variance in how the mind emerges, which in turn affects academic performance. Understanding the constraints and affordances of the physical ear with regard to incoming sound supports the embodied listening paradigm.
Detection of SARS-CoV-2 variant 501Y.V2 in Comoros Islands in January 2021
Authors: N. Agoti Charles , Githinji George , S. Mohammed Khadija , W. Lambisia Arnold , R. de Laurent Zaydah , W. Mburu Maureen , M. Ong’era Edidah , M. Morobe John , Otieno Edward , Abdou Azali Hamza , Said Abdallah Kamal , Diarra Abdoulaye , Ahmed Yahaya Ali , Borus Peter , Gumede Moeletsi Nicksy , Fred Athanasius Dratibi , Tsofa Benjamin , Bejon Philip , James Nokes D. , Isabella Ochola-Oyier Lynette
Published: July 2021

Background. Genomic data is key in understanding the spread and evolution of SARS-CoV-2 pandemic and informing the design and evaluation of interventions. However, SARS-CoV-2 genomic data remains scarce across Africa, with no reports yet from the Indian Ocean islands.

Methods. We genome sequenced six SARS-CoV-2 positive samples from the first major infection wave in the Union of Comoros in January 2021 and undertook detailed phylogenetic analysis.

Results. All the recovered six genomes classified within the 501Y.V2 variant of concern (also known as lineage B.1.351) and appeared to be from 2 sub-clusters with the most recent common ancestor dated 30th Oct-2020 (95% Credibility Interval: 06th Sep-2020 to 10th Dec-2020). Comparison of the Comoros genomes with those of 501Y.V2 variant of concern from other countries deposited into the GISAID database revealed their close association with viruses identified in France and Mayotte (part of the Comoros archipelago and a France, Overseas Department).

Conclusions. The recovered genomes, albeit few, confirmed local transmission following probably multiple introductions of the SARS-CoV-2 501Y.V2 variant of concern during the Comoros’s first major COVID-19 wave. These findings demonstrate the importance of genomic surveillance and have implications for ongoing control strategies on the islands.
Cerebral lateralisation of first and second languages in bilinguals assessed using functional transcranial Doppler ultrasound
Authors: Bishop Dorothy V. M. , Grabitz Clara R. , Harte Sophie C. , Watkins Kate E. , Sasaki Miho , Gutierrez-Sigut Eva , MacSweeney Mairéad , Woodhead Zoe V. J. , Payne Heather
Published: July 2021

Background: Lateralised language processing is a well-established finding in monolinguals. In bilinguals, studies using fMRI have typically found substantial regional overlap between the two languages, though results may be influenced by factors such as proficiency, age of acquisition and exposure to the second language. Few studies have focused specifically on individual differences in brain lateralisation, and those that have suggested reduced lateralisation may characterise representation of the second language (L2) in some bilingual individuals.

Methods: In Study 1, we used functional transcranial Doppler sonography (FTCD) to measure cerebral lateralisation in both languages in high proficiency bilinguals who varied in age of acquisition (AoA) of L2. They had German (N = 14) or French (N = 10) as their first language (L1) and English as their second language. FTCD was used to measure task-dependent blood flow velocity changes in the left and right middle cerebral arteries during phonological word generation cued by single letters. Language history measures and handedness were assessed through self-report. Study 2 followed a similar format with 25 Japanese (L1) /English (L2) bilinguals, with proficiency in their second language ranging from basic to advanced, using phonological and semantic word generation tasks with overt speech production.

Results: In Study 1, participants were significantly left lateralised for both L1 and L2, with a high correlation (r = .70) in the size of laterality indices for L1 and L2. In Study 2, again there was good agreement between LIs for the two languages (r = .77 for both word generation tasks). There was no evidence in either study of an effect of age of acquisition, though the sample sizes were too small to detect any but large effects. 

Conclusion: In proficient bilinguals, there is strong concordance for cerebral lateralisation of first and second language as assessed by a verbal fluency task.
Variable and Constant Returns-to-Scale Production Technologies with Component Processes
Authors: Podinovski Victor V.
Published: July 2021

Efficiency Analysis for Multicomponent Production Processes

Conventional models concerned with efficiency analysis of organizations typically consider a single production process, or technology, in which all inputs are used in the production of all outputs. This approach does not account well for the situations in which the organizations are involved in several component production processes whose inputs and outputs may be shared by different processes. The main difficulty in modeling such technologies is the fact that we often do not know the exact allocation of the shared inputs and outputs to individual processes. In “Variable and Constant Returns-to-Scale Production Technologies with Component Processes,” V. V. Podinovski shows how this problem can be overcome by the consideration of the worst-case scenario for the allocation of the shared inputs and outputs to different components of the technology. This approach leads to the development of multicomponent variants of two well-established nonparametric models. An application involving universities in England demonstrates the usefulness and improved discriminating power of the new models compared with their conventional analogues.
CT-based volumetric assessment of rotator cuff muscle in shoulder arthroplasty preoperative planning
Authors: Werthel Jean-David , Boux de Casson François , Burdin Valérie , Athwal George S. , Favard Luc , Chaoui Jean , Walch Gilles
Published: July 2021

Aims

The aim of this study was to describe a quantitative 3D CT method to measure rotator cuff muscle volume, atrophy, and balance in healthy controls and in three pathological shoulder cohorts.

Methods

In all, 102 CT scans were included in the analysis: 46 healthy, 21 cuff tear arthropathy (CTA), 18 irreparable rotator cuff tear (IRCT), and 17 primary osteoarthritis (OA). The four rotator cuff muscles were manually segmented and their volume, including intramuscular fat, was calculated. The normalized volume (NV) of each muscle was calculated by dividing muscle volume to the patient’s scapular bone volume. Muscle volume and percentage of muscle atrophy were compared between muscles and between cohorts.

Results

Rotator cuff muscle volume was significantly decreased in patients with OA, CTA, and IRCT compared to healthy patients (p < 0.0001). Atrophy was comparable for all muscles between CTA, IRCT, and OA patients, except for the supraspinatus, which was significantly more atrophied in CTA and IRCT (p = 0.002). In healthy shoulders, the anterior cuff represented 45% of the entire cuff, while the posterior cuff represented 40%. A similar partition between anterior and posterior cuff was also found in both CTA and IRCT patients. However, in OA patients, the relative volume of the anterior (42%) and posterior cuff (45%) were similar.

Conclusion

This study shows that rotator cuff muscle volume is significantly decreased in patients with OA, CTA, or IRCT compared to healthy patients, but that only minimal differences can be observed between the different pathological groups. This suggests that the influence of rotator cuff muscle volume and atrophy (including intramuscular fat) as an independent factor of outcome may be overestimated. Cite this article: Bone Jt Open 2021;2(7):552–561.
Nonlinear optical fullerene and graphene-based polymeric 1D photonic crystals: perspectives for slow and fast optical bistability
Authors: Kislyakov Ivan M. , Ivanov Pavel V. , Nunzi Jean-Michel , Vlasov Andrey Yu. , Ryzhov Anton A. , Venediktova Anastasia V. , Wang Hongqiang , Wang Zixin , Zhang Tianju , Dong Ningning , Wang Jun
Published: July 2021

Nonlinear optical (NLO) properties of materials can be enhanced by assembling them as thin polymer composite films alternating with other polymers and forming dielectric mirrors, 1D photonic crystals (1DPCs), wherein the input light intensity is increased. Based on the poly(vinyl carbazole) (PVK) and poly(vinyl alcohol) (PVA) contrasting polymer pair, variants of such structures, with graphene and fullerene in their high-index layers, have been produced. Their optical switching characteristics have been studied with ns, cw, and quasi-cw fs laser sources in the IR and with a fs laser in the visible range. We have demonstrated slow optical bistability in the polymeric 1DPCs determined by the thermal expansion of polymer composites at intensities over

100

W

/

c
m

2

as well as fast and ultrafast optical switching due to thermo-optic and Kerr nonlinearities, respectively. Characteristic nonlinear refractive coefficients responsible for these processes were found to be

n
2

t
o

∼

10

−
1

c
m

2

/

G
W

and

n
2

K
e
r
r

∼

10

−
4

c
m

2

/

G
W

. A subpicosecond fast spectral shift of the 1DPC bandgap has been found. Our results and analysis provide a clear picture of the NLO behavior of 1DPCs at different time scales. The results stimulate the subsequent design of ultrafast switches and bistable memory cells based on polymeric 1DPCs whose micrometer thickness and flexibility offer promise for implementation into fiber and microchip configurations.
Design of highly sensitive interferometric sensors based on subwavelength grating waveguides operating at the dispersion turning point
Authors: Huang Tianye , Xu Guizhen , Tu Xin , Zhang Gangshun , Lei Rongrong , Wu Yiheng , Pan Jianxing , Shao Liyang , Shum Perry Ping
Published: July 2021

In this paper, a dual-mode interferometric sensor based on a subwavelength grating (SWG) waveguide is proposed. The design operates at the dispersion turning point (DTP) of the two dispersive TE modes in the periodic structure, exhibiting a group velocity difference of almost zero, to improve the performance of refractive index (RI) sensors. The necessary conditions for realizing DTP in SWG are analyzed. Moreover, the interference spectrum characteristics and the influence of structural parameters on gas RI sensing performance are further studied. The results show that the sensitivity value of the proposed sensor can reach

∼

38

,

000

n
m

/

R
I
U

. The proposed structure can also achieve a gas pressure sensitivity of

∼

105

n
m

/

M
P
a

. The proposed sensors provide a potential platform for highly sensitive RI sensors.
Adaptive Lissajous scanning pattern design by phase modulation
Authors: Brunner David , Yoo Han Woong , Schroedter Richard , Schitter Georg
Published: July 2021

This paper proposes a phase modulation method for Lissajous scanning systems, which provides adaptive scan pattern design without changing the frame rate or the field of view. Based on a rigorous analysis of Lissajous scanning, phase modulation constrains and a method for pixel calculation are derived. An accurate and simple metric for resolution calculation is proposed based on the area spanned by neighboring pixels and used for scan pattern optimization also considering the scanner dynamics. The methods are implemented using MEMS mirrors for verification of the adaptive pattern shaping, where a 5-fold resolution improvement in a defined region of interest is demonstrated.
Reinforced design method for moiré metalens with large spacing
Authors: Qian Yongyue , Hu Bin , Du Zhiyuan , Liu Juan
Published: July 2021

Although metalens has attracted many research interests for its advantages of light weight, ultrathin size, and high design freedom in realizing achromatic and aberration-free optical devices, it still lacks adjustability in zoomable optical systems. Moiré metalens, which consists of two cascaded metasurface layers, can realize large focus tuning range by the mutual rotation of the two layers, and becomes a possible solution to realize real application of reconfigurable metalenses. However, due to the spacing between the two metasurface layers, it suffers from aberration caused by diffraction, leading to a dramatically decreased efficiency with the spacing. In this paper, we propose a reinforced design method for moiré metalenses with large spacing based on diffraction optics. Simulation results demonstrate that at the wavelength of 810 nm, when the spacing of the two metasurfaces is 10λ, the focusing efficiency of the reinforced moiré metalens is 3.4 times larger than the traditional moiré metalens. Furthermore, in order to consider the situation that the spacing between the two metasurfaces cannot be controlled precisely, we also propose a reinforced design method for multiplex spacings, which can make the device maintain a high focusing efficiency (3 times larger than the traditional moiré metalens) for the spacing in a range of 6λ∼10λ. The new design method is anticipated to be applied in realizing tunable metalenses in integrated continuously zoomable optical systems.
Theoretical prediction of photophoretic force on a dielectric sphere illuminated by a circularly symmetric high-order Bessel beam: on-axis case
Authors: Wang Haiyang , Wang Jiajie , Dong Wenqiang , Han Yiping , Ambrosio Leonardo A. , Liu Lei
Published: July 2021

Compared to the experimental progresses made in the optical trapping of aerosol particles in gaseous media by means of photophoretic forces, the theoretical analysis of photophoretic forces is less developed, the underlying mechanisms being yet not fully understood. In this paper, theoretical derivations of photopheresis of a dielectric sphere in gaseous media illuminated by a circularly symmetric Bessel beam of arbitrary order is presented within the framework of generalized Lorenz-Mie theory. An analytic and closed-form formula for the asymmetry factor, which ultimately determines the sense of direction of photophoretic force, is provided. The influences of particle size, absorptivity of the particle, half-cone angle, beam order of the Bessel beam on the asymmetry factor are explored in detail. The method proposed in this paper can be applied to a wider class of axisymmetric beams carrying nonzero topological charges.
Ferroelectric liquid crystal Pancharatnam-Berry lens with a fast control of output light’s polarization-handedness
Authors: Ma Ying , Yin Mingkui , Shan Yuhang , Liu Xiaoyu , Qi Shuxia , Chigrinov Vladimir G. , Kwok Hoi-Sing , Zhao Jianlin
Published: July 2021

We report the ferroelectric liquid crystal (FLC) Pancharatnam-Berry lenses (PBLs) with rapid transmittance tunability. The FLC PBLs were fabricated using a single-step holographic exposure system based on a spatial light modulator working as numerous polarization retarders, providing a simple way to fabricate FLC continuous aligning structures. A state-selection sector containing a binary FLC switch was utilized for fast changing input light’s polarization handedness. Thus, when light passes through a FLC PBL, the output light’s polarization handedness can be switched accordingly. In this case, FLC PBLs can function as concave/convex lenses with rapidly switching speed. Photo sensitive azo-dye material was used as the aligning layer for both FLC PBLs and FLC switches. The fabricated FLC PBLs and the FLC switches show fast switching-on times of 150μs and 50μs respectively. The FLC PBLs combining with the state-selection sector can have potential applications on varies displays and augmented reality.
Secure and practical multiparty quantum digital signatures
Authors: Weng Chen-Xun , Lu Yu-Shuo , Gao Rui-Qi , Xie Yuan-Mei , Gu Jie , Li Chen-Long , Li Bing-Hong , Yin Hua-Lei , Chen Zeng-Bing
Published: July 2021

Quantum digital signatures (QDSs) promise information-theoretic security against repudiation and forgery of messages. Compared with currently existing three-party QDS protocols, multiparty protocols have unique advantages in the practical case of more than two receivers when sending a mass message. However, complex security analysis, numerous quantum channels and low data utilization efficiency make it intractable to expand three-party to multiparty scenario. Here, based on six-state non-orthogonal encoding protocol, we propose an effective multiparty QDS framework to overcome these difficulties. The number of quantum channels in our protocol only linearly depends on the number of users. The post-matching method is introduced to enhance data utilization efficiency and make it linearly scale with the probability of detection events even for five-party scenario. Our work compensates for the absence of practical multiparty protocols, which paves the way for future QDS networks.
Watt-level 1.7-μm single-frequency thulium-doped fiber oscillator
Authors: Zhang Lu , Zhang Junxiang , Sheng Quan , Shi Chaodu , Shi Wei , Yao Jianquan
Published: July 2021

Here we demonstrated an efficient high-power single-frequency thulium-doped fiber ring laser operating at 1720 nm. Three cascaded sub-rings were inserted into the main cavity to significantly enlarge the effective free spectral range. By incorporating a fiber Bragg grating, the single longitudinal mode operation was achieved. The maximum single-frequency output power reached up to 1.11 W under 3.75-W launched pump power, while the slope efficiency with respect to the absorbed pump power was 46.4%. The laser linewidth at maximum single-frequency power was measured of 1.9 kHz. Potential power scaling of the single-frequency output power with different quantity and lengths of the sub-rings was also theoretically investigated.
Förster resonance energy transfer outpaces Auger recombination in CdTe/CdS quantum dots-rhodamine101 molecules system upon compression
Authors: Li Bo , Liu Yuliang , Wan Yongfeng , Zhu Lixia , Shi Ying , Liu Cailong , Jin Mingxing , Gao Jianbo , Ding Dajun
Published: July 2021

Förster resonance energy transfer (FRET) and Auger recombination in quantum dots (QDs)-molecules system are important mechanisms for affecting performance of their optoelectronic and photosynthesis devices. However, exploring an effective strategy to promote FRET and suppress Auger recombination simultaneously remains a daunting challenge. Here, we report that FRET process is promoted and Auger recombination process is suppressed in CdTe/CdS QDs-Rhodamine101 (Rh101) molecules system upon compression. The greatly improved FRET is attributed to the shortened donor-acceptor distance and increased the number of molecules attached to QDs induced by pressure. The reduced Auger recombination is ascribed to the formation of an alloy layer at the core/shell interface. The FRET can occur 70 times faster than Auger recombination under a high pressure of 0.9 GPa. Our findings demonstrate that high pressure is a robust tool to boost FRET and simultaneously suppress Auger recombination, and provides a new route to QDs-molecules applications.
Properties of the generation and propagation of spatiotemporal optical vortices
Authors: Huang Shunlin , Wang Peng , Shen Xiong , Liu Jun
Published: July 2021

Spatiotemporal optical vortex (STOV) light is a new type of vortex light with transverse orbital angular momentum (OAM) which is different from conventional spatial vortex light. Understanding the properties of STOV are meaningful before STOV are applied. We present a theoretical study on the generation and propagation of spatiotemporal vortices step by step based on diffraction theory. The properties of the output pulses with different topological charges generated using 4 f pulse shaper in both the near-field and the far-field are analyzed. Using spiral phase mask, the intensity profiles of the output pulses immediately after the 4 f pulse shaper are of multi-lobe structures. With energies circulating around the phase singularity in the space-time plane, energy coupling occurs between the spatial and temporal domains in the wave packets during propagation, then the intensity profiles evolve into multi-hole shapes, and the holes tend to be merged for higher order STOV. The conservation of OAM in the space-time domain is shown clearly. The profiles of the output pulses in the near-field form donut rectangle shapes using π-step mask, and in the far-field, they split into a multi-lobe structure. The rules of the generation and evolution of STOV are revealed. The results demonstrate the physical properties of the STOV and the generation and propagation processes directly and clearly. It provides a guidance on the application of STOV.
High-resolution digital spatial control of a highly multimode laser: erratum
Authors: Tradonsky Chene , Mahler Simon , Cai Gaodi , Pal Vishwa , Chriki Ronen , Friesem Asher A. , Davidson Nir
Published: July 2021

This erratum corrects typographical errors that appeared in Fig. 5 of
our earlier manuscript [Optica 8,
880 (2021)OPTIC82334-253610.1364/OPTICA.423140].
Setting up a pragmatic clinical trial in a low-resource setting: A qualitative assessment of GoLBeT, a trial of podoconiosis management in Northern Ethiopia
Authors: Erber Astrid C. , Ewing Victoria , Turner Mark , Molla Meseret , Murbe Gharib , Enquoselassie Fikre , Davey Gail , Lang Trudie
Published: July 2021

Background

Clinical trials are often perceived as being expensive, difficult and beyond the capacity of healthcare workers in low-resource settings. However, in order to improve healthcare coverage, the World Health Organization (WHO) World Health Report 2013 stated that all countries need to become generators as well as recipients of data. This study is a methodological examination of the steps and processes involved in setting up the Gojjam Lymphoedema Best Practice Trial (GoLBeT; ISRCTN67805210), a highly pragmatic clinical trial conducted in northern Ethiopia. Challenges to the trial and strategies used to deal with them were explored, together with the reasons for delays.

Methodology and principal findings

Qualitative research methods were used to analyse emails and reports from the period between trial inception and recruitment. This analysis was complemented by interviews with key informants from the trial operational team. The Global Health Research Process Map was used as a framework against which to compare the steps involved in setting up the trial. A mini-group discussion was conducted with the trial operational team after study completion for reflection and further recommendations.

This study showed that the key areas of difficulty in setting up and planning this trial were: the study design, that is, deciding on the study endpoint, where and how best to measure it, and assuring statistical power; recruitment and appropriate training of staff; planning for data quality; and gaining regulatory approvals. Collaboration, for example with statisticians, the trial steering committee, the study monitors, and members of the local community was essential to successfully setting up the trial.

Conclusions and significance

Lessons learnt from this trial might guide others planning pragmatic trials in settings where research is not common, allowing them to anticipate possible challenges and address them through trial design, planning and operational delivery. We also hope that this example might encourage similar pragmatic studies to be undertaken. Such studies are rarely undertaken or locally led, but are an accessible and efficient way to drive improved outcomes in public health.