bluuebunny/crossref_metadata_2025 huggingface dataset:
Definitive Sclerosing Intensity Modulated Radiotherapy in A Child with Recurrent Aneurysmal Bone Cyst- A Clinical Case from our Practice
Authors:   Medical Oncology ClinicRadiation and Metabolic Brachytherapy Department UMHAT “Queen Joanna” Sofia, Bulgaria, Marinova Lena , Vasileva Vaska ,   Medical Oncology ClinicRadiation and Metabolic Brachytherapy Department UMHAT “Queen Joanna” Sofia, Bulgaria, Kahchiev Nikolay ,   Medical Oncology ClinicRadiation and Metabolic Brachytherapy Department UMHAT “Queen Joanna” Sofia, Bulgaria, Sergieva Katia ,   Medical Oncology ClinicRadiation and Metabolic Brachytherapy Department UMHAT “Queen Joanna” Sofia, Bulgaria
Published: June 2024

Aneurysmal bone cysts (ABCs) are rarely diagnosed aggressive benign bone tumors. They are mainly diagnosed in children and adolescents in the long bones of the limbs, but in 12 %-30% are localized in the spine. Since the value of external beam radiotherapy (EBRT) for ABC has not been well defined, we present our observations and treatment outcome after one year from the definitive intensity modulated radiotherapy (IMRT) up to 30 Gy. for recurrent spine ABC in adolescent age
TECHNOMEDIA AS A SUBJECT OF PHILOSOPHICAL REFLECTION
Authors: Filonov Valery R.
Published: June 2024

This article analyzes the origins and significance of the practice of introducing telecommunication tools in the formation of a modern information society. The main focus is on the sociopolitical program of «media realism» and the role of technical innovations in its implementation. The author examines the philosophical concepts of M. Heidegger, B. Latour and M. Delanda, and their contribution to the development of an ontological understanding of the media space. Special attention is paid to identifying the pragmatic and cultural-psychological functions of the means of communication, their role in modern military-strategic discourse. The article emphasizes the militaristic nature of techno-media, revealing the material and technical basis of this sphere, which consists in the intensive interaction of communication actors and their struggle for control over information flows. The purpose of this article is to investigate the influence of techno-media on philosophical discourse and to discover its role in the modern media space. The research used methods of ontological analysis and a comparative historical approach to reveal the fundamental aspects of the relationship between the dynamics of the development of the media space and philosophical theories.
ENTROPY-RANDOMIZED ESTIMATION OF NONLINEAR DYNAMICAL MODEL PARAMETERS ON OBSERVATION OF DEPENDENT PROCESS
Authors: Popkov A.Y. , Dubnov Y.A. , Popkov Y.S.
Published: June 2024

The work is devoted to the development of the method of randomized machine learning in the direction of estimating dynamic models of related processes using real data, one of which is considered as the main one, and the other as a dependent one. The model of the main process in this concept is implemented by a dynamic model based on differential equations with parameters, which in turn are implemented by a static model in a different time scale. Randomized machine learning is a new theory at the intersection of data science, machine learning and data mining, based on the concept of entropy to estimate the probabilistic characteristics of model parameters. Such characteristics are the probability distributions of the corresponding objects, the estimates of which are the distributions implemented by the probability density functions or discrete distributions. Achieving this goal becomes possible thanks to the idea of moving from models with deterministic parameters to models with random parameters and, additionally, measured at the output with random noise, which achieves the consideration of the stochastic nature, which is obviously present in any natural phenomenon. As a demonstration of the proposed method, we consider the problem of predicting the total number of infected people based on the SIR dynamic epidemiological model, in which one of the parameters is considered as the state of the associated process implemented by the static model. Its evaluation is carried out according to the observations of the main process, and forecasting is carried out using the model of the associated one. Conducted experiment using real data on COVID-19 cases in Germany shows the efficiency of the proposed approach. The forecast obtained by the classical least squares method leads to an underestimation of the model output compared to the real observed data, while the proposed approach demonstrates more flexibility and potentially allows you to obtain forecasts that are more adequate to the real data, which confirms its effectiveness and adequacy under conditions a small amount of data with a high level of uncertainty.
LINEAR AND QUASILINEAR EQUATIONS WITH SEVERAL GERASIMOV - CAPUTO DERIVATIVES
Authors: Boyko K.V.
Published: June 2024

A representation of a solution of the Cauchy problem for a linear inhomogeneous equation
solved with respect to the oldest derivative with several fractional Gerasimov - Caputo
derivatives and with a sectorial pencil of linear closed operators at them in the case of the
Holder function in the right-hand side of the equation is obtained; the uniqueness of the
solution is proved. This result is used to reduce the Cauchy problem for the corresponding
quasilinear equation to an integro-differential equation. The existence of a unique local
solution is proved by the method of contraction operators in the case of local Lipschitz
nonlinear operator depending on several Gerasimov - Caputo derivatives in the equation
and a single global solution under the Lipschitz condition for this operator.
Деятельность участкового уполномоченного полиции. Часть первая (общая)
Authors:   Челябинский государственный университет, Горюнов Владимир Евгеньевич
Published: June 2024

Излагаются систематизированные базовые положения деятельности участкового уполномоченного полиции; учтены последние изменения и дополнения законодательства, а также современное состояние правоприменительной практики. Содержание учебника соответствует актуальным требованиям федерального государственного образовательного стандарта высшего образования. Издание предназначено для студентов, обучающихся по специальности 40.05.02 — Правоохранительная деятельность, и содержит основные теоретические вопросы, включаемые в билеты для зачетов и экзаменов.
Spatial and temporal trends of Tamanend’s bottlenose dolphin (Tursiops erebennus) strandings in South Carolina, USA, 2006–2020
Authors: Krzewinski Megan , McFee Wayne , Young Robert
Published: June 2024

Marine mammal strandings data contribute towards overall assessments of cetacean populations, including seasonal, annual and life‐history trends which result from both natural and anthropogenic causes. We conducted spatial and temporal analyses of Tamanend’s bottlenose dolphin (Tursiops erebennus) strandings in the waters of South Carolina, USA, over a 15‐year period from 2006 to 2020, with the following objectives: (1) to determine spatial and temporal trends; (2) to analyse seasonal reproductive trends; (3) to determine life‐history parameters, such as sex ratio and age class; (4) to determine the extent to which human interaction contributed to strandings; and (5) to compare stranding patterns with historical data from 1992–2005. A total of 837 strandings occurred over the study period, with a mean of 55.8 strandings per annum. The season with most strandings was Spring (April–June), while March and April had the highest number of strandings. A relatively equal number of male and females dolphins stranded, and mortality was highest in neonates, first‐year calves and adults. Neonatal strandings comprised 22.1% of all strandings and were predominant in May. Ninety‐five human‐interaction (HI) cases were observed, representing 22.9% of strandings where HI or non‐HI could be determined. Confirmed crab‐pot buoy‐line entanglements were the predominant HI category (n = 31). Density maps and hot spot analysis showed most strandings, including live and neonatal strandings and HI cases, occurred in defined areas of Charleston and Beaufort Counties. While many trends were similar to historical data, some new trends emerged, particularly an increase of strandings in March and April. Neonatal strandings decreased in November and the historical spike during this month has essentially disappeared. The results of this analysis serve as a tool to predict stranding rates and inform conservation and management decisions to better protect bottlenose dolphins.
Household Characteristics and Investment in Girl Child Education
Authors: Theresa Atakpo, Edirin , Nnenna Obed-Chukwuka, Anthonia , Nelson Akpotu, Ejiroghene
Published: June 2024

The research was carried out to ascertain how different household characteristics like marital status of parents, parents age, economic background, religion, type of family, occupation among others can affect investments in girl-child education. The design for the study was the descriptive survey research design. Four research objectives and a research hypothesis guided the study. The study population included all the parents of pupils in public primary schools in Delta Central senatorial district of Delta State which is about 1.2million parents. 1,116 parents were sampled from six selected local Government Areas in Delta central senatorial district representing about 10% of the population. A 4 sectioned self-structured questionnaire titled: Household Characteristics and Investment in Girl Child Education Questionnaire (HC1GCEQ) was designed by the researchers for the study. Descriptive statistics of mean and standard deviation were used for data analysis. A mean score of 2.50 and above indicated an effect on girl child education while, a mean score less than 2.50 indicated no effect on girl child education The research hypothesis was answered using Pearson product moment correlation statistic. The study revealed that Household characteristics affected girl child education in terms of type of school the girl child will attend, it affected the payment of extra levies, and it affected books and other supplies for the girl child. The recommendations based on the findings include continuous sensitization by government, workers, voluntary groups and organizations and child right and or girl child activists on the importance of girl child education especially among the rural areas and also financially empowering parents through gainful employment among others.
O JOGO DO TEXTO E A COCRIAÇÃO DE SIGNIFICADOS NO POEMA ‘AS SEM-RAZÕES DO AMOR’ DE CARLOS DRUMMOND DE ANDRADE: UMA ANÁLISE LITERÁRIA QUE CONTEXTUALIZA A IMPORTÂNCIA DA INTERAÇÃO LEITOR/TEXTO
Authors: Reinehr Stoffel Helena Teresinha , Oliveira Ramos Aloisio , Alberto Paes Marques de Oliveira Carlos , Ferreira da Silva Eliane , Souza Rêgo Katiuscia , Queiroz Gonçalves Leonardo , Aparecida da Costa Sanches Luciana , Solano Dias Valdirene
Published: June 2024

O objetivo deste artigo é analisar os recursos poéticos utilizados por Carlos Drummond de Andrade no poema 'As Sem-Razões do Amor', destacando como a sonoridade e o jogo de palavras desafiam e envolvem o leitor permitindo múltiplas interpretações e a criação de novos sentidos através da intertextualidade e do preenchimento das lacunas textuais deixadas pelo poeta. O estudo fundamenta-se nos conceitos do jogo do texto (Iser, 2002), nas teorias literárias que apontam o leitor como elemento participativo e na estética da recepção (Jauss, 1994) e nos escritos de Eco (1986) sobre o texto aberto. Em relação à metodologia, trata-se de uma análise qualitativa, na qual buscou-se interpretar, nas entrelinhas, a musicalidade e o jogo das palavras, sonoridade essa que possibilitou múltiplas interpretações por meio da intertextualidade estabelecida pelo leitor. Ao analisar o poema constatou-se que começo e fim estão interligados e que Drummond está fazendo uma crítica ao uso do amor sem amor. O movimento constante e o jogo de palavras é envolvente, instigam o receptor e o convidam a completar as lacunas existentes que necessitam da intervenção do leitor para completá-las, e ao fazê-lo, o leitor torna-se co-produtor do ato de criação. O poema explora profundamente a natureza inexplicável do amor, e por meio do jogo de palavras o poeta expressa a intencionalidade de nos levar a refletir sobre a sublimidade do amor, tão difícil, senão impossível de explicar, mas nos convence de que ninguém manda no coração.
seletividade penal e a priorização da punição da criminalidade de rua
Authors: Gianecchini Giulia Palermo Guimarães , Toffano Marcelo , Lannes Yuri Nathan da Costa
Published: June 2024

O presente artigo tem como objetivo efetuar uma análise crítica acerca dos Delitos Corporativos e dos Crimes de Rua, com enfoque na responsabilidade penal das pessoas jurídicas no Brasil, e um breve estudo do caso de rompimento de uma barragem da empresa VALE S/A na cidade de Brumadinho/MG e sua possibilidade de responsabilização. A VALE S/A, apesar de possuir um sistema de compliance, para possível avaliação de riscos, este se demonstrou frágil e extremamente ineficaz. Uma Comissão Parlamentar de Inquérito foi criada para investigar o caso, o Ministério Público mineiro também produziu provas, porém muito tempo se passou e será discutido se de fato houve a responsabilização da mineradora. Como metodologia, foi utilizado o método dedutivo, além de pesquisas bibliográficas, legais e documentais.
Leading-edge Metaverse in education: framework, applications, challenges, and future development
Authors: Rane Nitin , Choudhary Saurabh , Rane Jayesh
Published: June 2024

The incorporation of cutting-edge metaverse technologies into the field of education has emerged as a transformative paradigm, reshaping conventional learning environments and paving the way for novel immersive and interactive educational experiences. This paper undertakes a comprehensive examination of the framework, applications, challenges, and future development prospects of metaverse technologies within the educational domain, focusing on a diverse array of techniques that contribute to the continuous evolution of this innovative educational landscape. The framework analysis delves into the design and implementation strategies that form the foundation of metaverse-based educational platforms. Utilizing augmented reality (AR), virtual reality (VR), and mixed reality (MR), these frameworks strive to create dynamic and captivating learning environments that transcend geographical limitations. The paper explores how these technologies enable realistic simulations, collaborative problem-solving, and experiential learning, thereby fostering a more interactive and participatory educational experience. Case studies and examples illustrate their utilization across disciplines, spanning from science and mathematics to humanities and vocational training. The paper underscores the significance of artificial intelligence (AI) and machine learning (ML) algorithms in tailoring educational content to individual learning styles, thereby enhancing personalization and adaptability within metaverse-based educational systems. Nevertheless, the research also addresses the challenges associated with implementing metaverse technologies in education. Issues such as accessibility, digital equity, and data privacy are discussed, accompanied by considerations for overcoming these challenges to ensure a more inclusive and secure educational landscape. Looking ahead, the paper outlines potential developments in metaverse education, exploring emerging technologies and trends such as blockchain-based credentialing, haptic feedback integration, and the incorporation of the Internet of Things (IoT). The paper acknowledges the diverse techniques contributing to its ongoing evolution, emphasizing the dynamic nature of this transformative educational landscape.
Where Motivation and Learning Meet: Bringing Key Concepts, Research Insights, and Effective Practices Together into the Language Classroom
Authors:   Universidad Nacional de Educación (UNAE), Ortega Auquilla Diego , Soto Sandy ,   Universidad de Vigo, Espinosa Cevallos Ligia Fernanda ,   Universidad Regional Amazónica Ikiam
Published: June 2024

This book delves into the critical role of motivation in the learning and teaching of English as a foreign language, emphasizing its necessity for effective language acquisition. It explores theoretical perspectives and practical strategies to foster motivation among university students in Ecuador, presenting key research findings and innovative teaching methodologies. The work highlights the importance of creating motivating learning environments and offers a range of techniques to enhance English learning both inside and outside the classroom, aiming to improve educational outcomes and student engagement across various educational levels.
Motivation in Education: The Road to Successful Learning
Authors:   Universidad Regional Amazónica Ikiam, Espinosa Cevallos Ligia Fernanda , Ruiz Peñafiel Verónica Marisol ,   Universidad Nacional de Educación, Bonilla Marchán Andrés Marcelo ,   University of the Armed Forces (ESPE)
Published: June 2024

In an era defined by globalization and advancements in communication technologies, education demands innovative teaching strategies and educators who can effectively manage learning processes. This involves fostering student autonomy rather than mere knowledge accumulation. Motivation, encompassing both external and internal influences on actions, plays a pivotal role in this context. It originates from the interplay of needs, desires, and stimuli, driving the intention, capacity, and effort required for learning activities. Teachers are central to nurturing motivation by understanding students' interests and creating a supportive environment that encourages curiosity and active participation. This involves a shift towards a more constructive and engaging learning experience, where students are active contributors in a respectful and dialogic educational relationship. Recognizing and rewarding students' efforts are essential for building trust and promoting success, aligning with the ultimate goal of education: enabling students to navigate their paths to achievement.
Innovation in Foreign Language Teaching and Learning: The Key for Student Motivation.
Authors:   Universidad Nacional de Loja, Troya Sánchez Miriam Eucevia , Moreno Ordóñez Rosa Paola ,   Universidad Nacional de Loja, Molina Perez Erika Micaela ,   Universidad Nacional de Loja
Published: June 2024

This chapter explores innovative approaches in teaching English as a foreign language (TEFL), aiming to surpass the limitations of traditional methods that hinder learner motivation. It's structured into two main sections: a systematic review of recent educational innovations and a detailed examination of Kumaravadivelu’s postmethod pedagogy, which aligns with Keller’s ARCS motivational model (Attention, Relevance, Confidence, Satisfaction). Through addressing key research questions, the chapter delves into how innovations in foreign language teaching and learning can refresh education, the impact of technology on innovation and student motivation, the most effective methods for incorporating technology into TEFL, and the postmethod’s potential in ensuring efficient English language teaching and learning.
Relación entre circunferencia de cuello y perfil lipídico en adultos: un análisis prospectivo de la Encuesta Nacional de Salud 2009-2010 de Chile
Authors: Parada-Flores Bastian , Guerra-Parra Marcela , Medel-Sepúlveda Paz , Vergara-Rojas Daniela , Faúndez-Casanova César
Published: June 2024

Objetivo: Investigar la relación entre circunferencia de cuello (CC) y perfil lipídico en adultos de la población chilena. Métodos: Se utilizó un diseño prospectivo correlacional entre las variables de CC y perfil lipídico de los participantes de la Encuesta Nacional de Salud (ENS) 2009-2010 de Chile, correspondientes a 1.852 adultos de entre 25 y 44 años. Resultados: el análisis reportó una correlación positiva entre CC y niveles de triglicéridos (0,36), colesterol total (0,20) y colesterol LDL (0,18), así como una correlación negativa respecto del colesterol HDL (-0,36). Conclusión: se concluye que la CC se relaciona estadísticamente con los parámetros de perfil lipídico de adultos de la población de Chile y se sugiere incorporar esta medición antropométrica de manera complementaria a la evaluación nutricional.
Enhancing Consumer and Planetary Well-Being by Consuming Less, Consuming Better
Authors: Sen Sankar , Bhattacharya CB , Lindrud Kristin , Bellezza Silvia , Cornil Yann , Du Shuili , Goenka Shreyans , Husemann Katharina , Johnson Eric J. , Lamberton Cait , Nenkov Gergana , Trudel Remi , White Katherine , Winterich Karen Page
Published: June 2024

The urgent need to address unsustainable consumption practices has become increasingly evident. While much traditional consumer behavior research serves to stimulate consumption, the focus needs to shift towards encouraging more sustainable consumption patterns. This commentary synthesizes insights from a roundtable discussion at the 2023 Society for Consumer Psychology Conference, which comprised an exploration of novel, creative, actionable, and theoretically sound avenues for getting people to consume less, consume better. The commentary tackles three essential questions: (1) What do we mean by consuming less, consuming better? (2) Who is/are responsible for such behaviors? (3) How do we get people to consume less, consume better? In doing so, it lays out several future research directions.
Implementasi Sistem Informasi Sekolah Dasar Menggunakan Metodologi Rapid Application Development (RAD): Studi Kasus di SD Sekolah Dasar Inpres Bangkala 3
Authors: Rijal Muhammad , Istiqamah Nurul , Aziz Firman
Published: June 2024

Sekolah Dasar Inpres Bangkala 3 adalah salah satu lembaga pendidikan dasar yang terletak di Kota Makassar, Penyampaian informasi secara cepat dan efektif dalam era modern saat ini menjadi tantangan karena umumnya dalam penyebaran informasi  masih mengandalkan metode tradisional seperti spanduk, yang memerlukan waktu dan biaya yang cukup besar. Penelitian ini bertujuan untuk membuat sebuah website Sekolah Dasar yang menarik dan mudah diakses melalui internet. Metode penelitian yang digunakan adalah Rapid Application Development (RAD), yang mencakup studi pustaka, observasi, analisis dan desain, pembuatan website, serta implementasi. Hasil penelitian menunjukkan bahwa website ini mampu mempercepat penyebaran informasi, mengurangi biaya operasional, dan memperluas jangkauan audiens. Dengan demikian, Sekolah Dasar Inpres Bangkala 3 dapat lebih dikenal oleh masyarakat luas dan informasi mengenai sekolah dapat diakses dengan lebih lengkap dan jelas. Segala informasi dari sekolah dapat lebih mudah disosialisasikan secara melalui platform digital ini.
Navigating Conflict and Health in Bawku, Ghana: Implications for Resolution and Management
Authors: Kipo-Sunyehzi Daniel Dramani , Suaka Yaro David , Titigah Gregory
Published: June 2024

The main goal of this study was to evaluate how conflicts are resolved and how they affect people's ability to access health care in Bawku, Ghana. Specific objectives were to assess factors that affect the management of the Bawku conflict and to evaluate the consequences of the conflict on health services in the Bawku region. The residents living in different locations of Bawku in the Upper East Region of Ghana comprised the target population, which was 144,189 persons. Forty-five (45) respondents were selected using an expert purposive sample methodology with an explanatory sequential design in a mixed method approach. The study was guided by the Protracted Social Conflict Theory. Basic statistical techniques were used in data analysis. The study used questionnaires and interview guides as its main methods for gathering data during the month of July 2023 in the Bawku region. The findings are presented through tables and charts. According to the findings, the Bawku War made it very difficult for residents to get access to medical facilities and services. The worst effects were seen in terms of casualties, wounds, and disruptions to regular life. In addition, the research identifies the best and most frequently used mechanisms for conflict resolution, which include the employment of the military and law enforcement, traditional councils, and houses of chiefs. Furthermore, the study concluded that the ethnic ties of the Mamprusis and Kusasis to other ethnic groups in these nations could potentially lead to the spread of the Bawku conflict to neighboring countries, particularly Togo and Burkina Faso. The study recommends a decrease in hostilities and, potentially, advocates for the complete cessation of political interference in the conflict resolution process in Bawku, located in the Upper East Region of Ghana.
CONDIÇÃO FÍSICA, MENTAL E SOCIAL DO CUIDADOR FAMILIAR RELACIONADO A SOBRECARGA: UMA REVISÃO INTEGRATIVA DA LITERATURA
Authors: Costa Nayure de Souza , Ferreira Shirley Kellen , Ramos Thallita de Freitas
Published: June 2024

Assumir o papel de cuidador e suas responsabilidades é uma tarefa exigente. Este pode ser membro da família ou não, que presta assistência a idosos, enfermos ou dependentes em suas atividades diárias, e isso pode levar o cuidador a enfrentar desafios para os quais normalmente não está preparado, resultando em sobrecarga de trabalho. Objetivando identificar as condições físicas, mentais e sociais de cuidadores familiares foi realizada esta pesquisa, do tipo Revisão Integrativa, considerada uma metodologia de abordagem ampla para avaliar, sintetizar e buscar evidências, cujas buscas se deram de setembro a novembro de 2023, nas bases de dados: LILACS (Literatura Latino-Americana e do Caribe de Informação em Ciências da Saúde), Medline (Medical Literature Analysis and Online Retrieval System), BDENF – Base de Dados de Enfermagem), via Portal (BVS) Biblioteca Virtual em Saúde, PubMed, SciELO (Science e Library Online), IBESC (Indice Bibliográfico Espanhol em Ciências da Saúde). Os resultados evidenciaram que cuidadores familiares desempenham um papel crucial no cuidado, mas também enfrentam suas próprias batalhas de saúde. Os mesmos apresentaram sentimentos de angústia, tristeza, ansiedade, culpa, remorso, irritabilidade e nervosismo. O estresse e a sobrecarga associados ao cuidado podem impactar a qualidade do relacionamento e provocar o abandono de atividades pessoais e sociais que podem gerar isolamento. Conclui-se que as repercussões nas condições físicas, mentais e sociais dos cuidadores familiares descritas na literatura podem variar, mas geralmente mostram padrões comuns. E que o estado de saúde do cuidador está relacionado ao nível de dependência do familiar.
POLÍTICAS DE DROGAS E ATENÇÃO À SAÚDE MENTAL DE CRIANÇAS E ADOLESCENTES: REVISÃO DE ESCOPO
Authors: Caetano Núbia Dias Costa , Souza Adriano Rodrigues de , Bessa Maria Eliana Peixoto , Paula Juliana Braga de
Published: June 2024

O estudo teve como objetivo identificar pesquisas sobre o desenvolvimento de políticas de drogas para crianças e adolescentes no contexto da saúde mental pública. Realizou-se uma revisão de escopo entre julho e agosto de 2021 nas bases BVS, SciELO, Scopus e PubMed, utilizando os descritores drogas, saúde mental, adolescente e criança. Dez artigos foram incluídos, selecionados conforme critérios de inclusão e exclusão, publicados entre 2011 e 2021. A análise das políticas de drogas para crianças e adolescentes no âmbito da saúde mental revelou um processo de implementação que varia entre diretrizes compatíveis com a atenção psicossocial e uma abordagem fragmentada e "tutelar". Concluiu-se que os serviços de saúde mental devem garantir uma atenção psicossocial abrangente e acolhedora para crianças e adolescentes, assegurando assistência integral que atenda às necessidades desse grupo como sujeitos de direitos.
Les télomères
Authors: Saintomé Carole
Published: June 2024

L’évolution a doté les organismes eucaryotes de chromosomes linéaires, équipant chaque chromosome d’extrémités qui sont protégées par une structure particulière nommée « télomère ». L’effet considérable des télomères sur la stabilité globale du génome et leur implication dans le vieillissement et le cancer ont contribué à leur fascination.Cet ouvrage présente les télomères en tant qu’exemple de diversité et d’unité du vivant, à travers les nombreux modèles qui y sont décrits (ciliés, levures, cellules humaines ou modèle souris). Dans la première partie, les auteurs introduisent l’histoire de leur découverte, leurs rôles biologiques, leurs aspects structuraux (séquences, longueur, protéines du complexe shelterine, structures G4 et T-loop, compaction et ancrage) et fonctionnels (réplication, transcription, maintien). La seconde partie explore leurs dysfonctionnements, les conséquences sur la santé humaine et les approches thérapeutiques.Les télomères est rédigé par des chimistes, biochimistes, structuralistes et biologistes illustrant ainsi l’interdisciplinarité de l’étude des télomères.
Contrôle et prévention des risques biologiques associés à la contamination des aliments
Authors: Bénézech Thierry , Faille Christine
Published: June 2024

Tout au long de la chaîne alimentaire, les aliments peuvent être exposés à des agents pathogènes qui peuvent affecter leur qualité et donc la santé des consommateurs. Cet ouvrage traite de la gestion des risques et spécifiquement les risques microbiologiques.Après le stade de la production primaire, avoir une bonne connaissance des stratégies et des moyens de contrôle mis en oeuvre tout au long de la chaîne alimentaire est une condition nécessaire et un préalable à toute amélioration ultérieure, mais elle n’est pas suffisante. Pour mieux prévenir et maîtriser ces risques, il est indispensable d’étudier les phénomènes de contamination de surface et ceux relatifs à l’élimination de cette contamination par des opérations de nettoyage et de désinfection afin d’en connaître les principaux mécanismes.Contrôle et prévention des risques biologiques associés à la contamination des aliments fait le point sur les stratégies existantes et explore un certain nombre d’innovations (nouvelles surfaces, nouveaux matériaux et procédures de nettoyage et de désinfection, etc.), pour des développements futurs à l’échelle industrielle ou domestique.
Saccharomyces cerevisiae, un modèle à l’avant-garde de la biologie des télomères
Authors: BARASCU Aurélia , TEIXEIRA Maria Teresa
Published: June 2024

Les télomères sont des structures spécialisées qui jouent un rôle central dans le maintien de la stabilité du génome des cellules eucaryotes. Dans ce chapitre nous allons aborder les découvertes passées et présentes établies chez Saccharomyces cerevisiae concernant les télomères et la télomérase, dont la plupart ont fait émerger des mécanismes biologiques conservés au cours de l’évolution.
CRISPR-Cas : un système immunitaire adaptatif
Authors: TOUCHON Marie
Published: June 2024

Un système CRISPR-Cas est un système immunitaire adaptatif présent chez les bactéries et archées qui cible et détruit spécifiquement le matériel génétique des agents invasifs, tels que les virus. Ce chapitre explore la diversité, l’évolution et le fonctionnement de ce type de systèmes. Il aborde également leurs impacts sur l’évolution conjointe des microbes et de leurs parasites, ainsi que leur importance dans la nature.
L’Europe, un continent ? Une analyse géohistorique
Authors: CAPDEPUY Vincent
Published: June 2024

L’Europe est un continent. Le propos semble convenu. Pourtant, si on applique la définition générale de "continent" à l’espace qu’on appelle « Europe », l’affirmation devrait être considé-rée comme un non-sens. L’enjeu de ce chapitre est de retracer l’histoire de ce découpage géo-graphique : comment en sommes-nous venus à parler d'un continent européen et à vouloir son unification politique ?
Les découpages de l’UE pour son développement
Authors: SANTAMARIA Frédéric
Published: June 2024

L’UE mobilise plusieurs types de découpages pour mettre en œuvre son aménagement et son développement territorial. Certains visent à promouvoir la dimension régionale, d’autres ont pour but de territorialiser l’action. Si les découpages semblent consubstantiels à l’action d’aménagement, les difficultés que connaît l’UE à faire valoir ses découpages l’ont conduite à mettre en avant l’idée de gouvernance territoriale.
L’Europe, l’eau et les découpages : districts hydrographiques et masses d’eau
Authors: GHIOTTI Stéphane , RIVIÈRE-HONEGGER Anne
Published: June 2024

Ce chapitre interroge de manière diachronique les enjeux autour de la construction, de l’adoption et de la mise en œuvre – au travers des situations française et européenne – des référentiels spatiaux naturels que sont le bassin versant avec le district hydrographique et la masse d’eau dans le cadre de la Directive Cadre sur l’Eau depuis 2000.
An empirically-derived hydraulic head model controlling water storage and outflow over a decade in degraded permafrost rock slopes (Zugspitze, D/A)
Authors: Scandroglio Riccardo , Weber Samuel , Rehm Till , Krautblatter Michael
Published: June 2024

Abstract. While recent permafrost degradation in Alpine peri- and paraglacial slopes has been documented in several studies, only restricted information is available on the respective hydrology. Water boosts permafrost degradation by advective heat transport and destabilizes periglacial mountain slopes. Even if multiple recent rock slope failures indicate the presence of water, only a few studies provide evidence of water availability and related hydrostatic pressures at bigger depths, showing a significant research gap. This study combines a unique decennial data set of meteorological data, snowmelt modeling, and discharge measurements from two rock fractures in a tunnel located ≈ 55 m under the permafrost-affected N-S facing Zugspitze Ridge (2815–2962 m asl). To decipher the hydrological properties of fractures, we analyze inputs, i.e., snowmelt and rainfall, and outputs, i.e., discharge from fractures, baseflow, and no-flow events, detecting flow anomalies. For summer precipitation events, we developed i) a uniform recession curve, ii) an empirical water storage model, and iii) an approximate hydraulic water pressure model according to Darcy’s falling-head law. Extreme events with up to 800 l/d and 58 l/h are likely to fully saturate the observed fractures with corresponding hydraulic heads of up to 40 ± 10 m and to increase fracture interconnectivity. The average daily discharge during snowmelt, 10 l/h, can lead to hydraulic heads up to 27 ± 6 m. Water dynamics suggest hydraulic conductivities in the range of 10−4 m/s, with variations according to the fracture’s saturation. E.g., no-flow and baseflow events indicate unsaturated and partially saturated conditions. Here, we show an empirical fluid flow approximation model of hydrostatic pressure regimes in high-alpine deep-bedrock fractures. Pressures from water accumulation in bedrock reach levels that can weaken or even destabilize rock slopes. This process can easily outpace thermal conductive warming of active layers in the foreseeable future, provide positive feedback on water infiltration, and is crucial for the stability of the rapidly warming alpine permafrost environments.
Signs of climate variability in double tropopause global distribution from radio occultation data
Authors: de la Torre Alejandro , Alexander Peter , Schmidt Torsten , Steiner Andrea K. , Ladstädter Florian , Hierro Rodrigo , Llamedo Pablo
Published: June 2024

Abstract. In a standard atmosphere, there is a single lapse rate tropopause (in what follows, tropopause) that separates the troposphere below from the stratosphere above. However, in certain situations, such as in regions of strong vertical wind shear or associated with certain weather phenomena, a second tropopause layer may form above the standard tropopause. The presence of a double tropopause (DT) can have implications for atmospheric and climate studies, as it may be associated with dynamic and complex weather patterns. Based on 14 years of temperature profiles retrieved by GNSS radio occultation and the resulting DT, a possible relationship between the spatio-temporal distribution of the relative number of DT to simple tropopauses (NDT) (or dependent variable) and a set of monthly climate indices (or features) is explored with a focus on the methodological approach. A cluster analysis is applied to geographically associate the DT occurrences with the climate indices. Then a multivariate linear regression is constructed using a progression of different models to identify the relevant features for the occurrence of DTs. On a global scale, from a hierarchical cluster analysis six sub-regions with different location and spread characteristics are identified. In addition to the condition of linearity in the residuals, the performance of each model in the train and test populations is evaluated to discard possible overfitting. The required conditions of non-collinearity, stationarity and cross-correlation between the features and the relative number of NDT after the removal of the climatological mean for each month (NDT’) are checked. Mean squared errors, adjusted coefficient of determination (adjusted R2) and number of degrees of freedom (F-statistic) parameters are evaluated for each model obtained. Taking into account the constraints of the present analysis, the most relevant climatic indices for the distribution of NDT' are identified.
Assessing effects of climate and technology uncertainties in large natural resource allocation problems
Authors: Steinbuks Jevgenijs , Cai Yongyang , Jaegermeyr Jonas , Hertel Thomas W.
Published: June 2024

Abstract. The productivity of the world's natural resources is critically dependent on a variety of highly uncertain factors, which obscure individual investors and governments that seek to make long-term, sometimes irreversible, investments in their exploration and utilization. These dynamic considerations are poorly represented in disaggregated resource models, as incorporating uncertainty into large-dimensional problems presents a challenging computational task. In this paper, we apply the SCEQ algorithm (Cai and Judd, 2023) to solve a large-scale dynamic stochastic global land resource use problem with stochastic crop yields due to adverse climate impacts and limits on further technological progress. For the same model parameters and bounded shocks, the range of land conversion is considerably smaller for the dynamic stochastic model than for deterministic scenario analysis.
Yersel Lazer tarama ile Tarihi yapının modellenmesi: Hamidiye Saatli Çeşme Örneği
Authors: Aydoğan Nisanur , Yiğit Efsa
Published: June 2024

Nesnelerin daha hassas ve kapsamlı 3B temsillerini elde etme olasılığı, araştırma alanında yeni yer tabanlı lazer tarayıcı teknolojilerinin ortaya çıkmasıyla artmıştır. Bu durum öncelikle, nesnelerin tipik olarak son derece karmaşık şekillere sahip olduğu mimari ve arkeolojik yüzey araştırması alanında geçerlidir. Buna ek olarak, lazer tarayıcı cihazları kullanılarak yapılan alım işlemi oldukça hızlı ve ekonomiktir ve ortaya çıkan 3B modeller kullanıcılar için oldukça faydalıdır. Bununla birlikte, lazer tarayıcıdan gelen verileri analiz ederken, yorumlarken ve modellerken ekstra özen gösterilmesi gerekir.
Mimari ve arkeolojik eserlerin çoğu son derece karmaşık şekillere sahiptir, bu da nesneyi tam olarak tanımlamak için taramayı gerekli kılar. Birçok durumda, gölgeli kısımları çıkarmak için aynı nesnenin çeşitli açılardan alınmış iki veya daha fazla taraması gerekir. Bu nedenle, uygun kayıt teknikleri kullanılarak, nesnenin nihai 3B modelini oluşturmak için tek tek taramaların hizalanması önemlidir. Bu çalışmada Hamidiye saatli çeşmesinin lazer tarama teknolojisi yardımıyla yersel lazer tarama cihazı kullanılarak elde edilen nokta bulutundan 3 boyutlu model üretilmiştir.
PENGEMBANGAN MODEL LATIHAN SMASH PADA OLAHRAGA BULUTANGKIS
Authors: Nurbait Syifa , Setia Cahya , Agustin Nur Mahfuzah
Published: June 2024

Tujuan dari penelitian ini adalah untuk menghasilakan model latihan smash pada olahraga bulutangkis untuk usia remaja, selain itu pengembangan penelitian ini dilakukan untuk memperoleh keefektifitasan, efsien serta daya tarik atlet dari model latihan yang diterapkan.
Penelitian ini menggunakan metode pengembangan R n D (Research and Development) yang dikutip dari ahli penelitian yaitu Brog dan Gall. Subjek penelitian dan pengembangan ini adalah atlet remaja bulutangkis berjumlah 45 anak.
Instrument penelitian dan pengembangan ini menggunakan angket,  kuisioner dan tes smash bukutangkis yang digunakan untuk mengumpulkan data. Adapun tahapan dalam penelitian dan pengembangan ini sebagai berikut: 1) analisis kebutuhan, 2) evaluasi ahli (produk awal), 3) uji coba terbatas (ujicoba kelompok kecil), 4) ujicoba utama (field testing), uji efekttifitas model menggunakan tes smash untuk mengetahui tingkat kemampuan smash setelah perlakuan atau treatment model smash yang dikembangkan, dari tes awal yang dilakukan memperoleh tingkat smash atlet sebesar 1349, kemudian setelah diberikan perlakuan berupa model smash memperoleh tingkat kemampuan smash atlet sebesar 1846. Maka model smash bulutangkis ini efektif dalam meningkatkan kemampuan smash bulutangkis untuk usia remaja.
Berdasarkan hasil pengembangan dapat disimpulkan bahwa: 1) model latihan smash bulutangkis untuk usia remaja dapat dikembangkan dan diterapkan dalam latihan bulutangkis, 2) model latihan smash untuk usia remaja yang telah dikembangkan, maka diperoleh adanya peningkatan. Hal ini ditunjukan dengan adanya perbedaan dari hasil pengujian pretest dan posttest yang signifikan antara sebelum dan sesudah adanya perlakuan.
MODEL CTL DALAM PENINGKATAN PEMBELAJARAN UANG DAN LEMBAGA KEUANGAN SISWA KELAS IX G SMPN 11 CIREBON
Authors: Leni Herliani
Published: June 2024

Penelitian ini mengangkat sebuah fenomena pembelajaran di kelas yang dikemas dalam sebuah Penelitian Tindakan Kelas dengan judul “Model CTL dalam Peningkatan Pembelajaran Uang dan Lembaga Keuangan Siswa Kelas IX G SMPN 11 Cirebon”. Penelitian ini menggunakan metode kualitatif dan teknik observasi dengan penekanan pada proses pembelajaran di kelas. Populasi dalam penelitian ini 37 siswa, terdiri dari 19 siswa laki-laki dan 18 siswa perempuan.Sampel penelitian siswa kelas IX G semester ganjil SMP Negeri 11 Cirebon Tahun Pelajaran 2018-2019. Data yang dikumpulkan bersumber dari PTK yang mencakup: 1) Perencanaan, 2) Pelaksanaan, 3) Observasi, dan 4) Refleksi sebanyak dua siklus. Temuan penelitian ini sebagai berikut: (1) umumnya perhatian siswa pada proses pembelajaran meningkat, (2) keberanian siswa meningkat, (3) kualitas jawaban siswa meningkat, (4) kesungguhan dan kemampuan siswa untuk mengajukan pertanyaan meningkat, (5) kemampuan dan kejelian siswa untuk menghindari kesalahan menjawab pertanyaan guru meningkat, (6) perhatian, cara, kesungguhan dan kemampuan siswa dalam menyelesaikan soal yang sulit maupun tidak sulit meningkat, (7) siswa yang mengajukan pertanyaan, tanggapan, komentar, saran, dan kritik terhadap soal yang diberikan guru meningkat, (8) jumlah siswa yang memperoleh peningkatan nilai dari dari sebelumnya meningkat, (9) jumlah siswa yang memperoleh penurunan nilai dari sebelumnya berkurang, (10) hasil belajar siswa baik secara individual maupun kelompok mengalami peningkatan, pada siklus pertama dari rata-rata 5,65 menjadi 8,20 pada siklus kedua, mengalami peningkatan 45,13%. Informasi balikan siswa juga menunjukkan bahwa pembelajaran CTL mendapat respon positif terbukti dengan rata-rata 2,72 (baik). Hal ini menunjukkan bahwa siswa senang dengan menggunakan pembelajaran CTL. Berdasarkan temuan di atas, peneliti merekomendasikan bahwa pembelajaran dengan model pembelajaran CTL pada umumnya dapat dipakai sebagai model dalam pembelajaran uang.
PENGARUH BUDIDAYA IKAN CUPANG TERHADAP PENINGKATAN PENDAPATAN KELUARGA DI KABUPATEN CIREBON
Authors: Eulis Henda  , Asep Kostajaya  , Handira
Published: June 2024

Penelitian ini dilaksanakan pada bulan Oktober hingga November 2020 pada budidaya ikan cupang di Kabupaten Gunung Jati. Tujuan dari penelitian ini adalah untuk mengetahui faktor-faktor yang melatarbelakangi pembudidaya memilih membudidayakan ikan cupang, serta besarnya pengaruh agribisnis ikan cupang dalam upaya meningkatkan pendapatan kelompok Perhimpunan Guppy Cupang Cirebon (PGCC) di Gunung Jati. Daerah. Penelitian ini menggunakan metode survei. Data dalam penelitian ini diperoleh melalui observasi, wawancara dan studi literatur yang kemudian diolah untuk mengetahui biaya dan keuntungan yang diperoleh dari budidaya ikan cupang. Sampel yang digunakan dalam penelitian ini adalah lima orang pembudidaya ikan cupang di kabupaten Gunung Jati. Dari hasil penelitian ini diketahui bahwa faktor yang melatarbelakangi pemilihan pembudidaya untuk membudidayakan ikan cupang dilihat dari analisis faktor kekuatan (strength) diantaranya potensi lahan yang masih luas, teknik budidaya ikan cupang. ikan itu mudah. pembudidaya yang rutin mengadakan sayembara. Kelemahan (weaknesses) antara lain harga jual yang relatif murah, kondisi ikan yang bergantung pada perawatan dan pemeliharaan yang baik, serta teknik budidaya yang konvensional. Faktor peluang (opportunity) antara lain dapat dijadikan sebagai usaha sampingan atau paruh waktu dengan modal kecil, adanya sayembara/perlombaan yang diadakan secara rutin, berkembangnya jejaring koperasi bagi anggota kelompok budidaya. Serta faktor ancaman (threats), antara lain persaingan antar penjual yang semakin ketat, kondisi cuaca yang tidak menentu, dan penyakit ikan cupang. Dengan memanfaatkan kekuatan dan peluang yang ada serta mengatasi kelemahan dan ancaman, kelima pembudidaya memilih untuk memulai usaha ikan cupang. Melalui penelitian ini diketahui bahwa total keuntungan yang diperoleh setiap pembudidaya ikan cupang cukup besar. Sehingga secara finansial dapat diberikan bahwa membudidayakan ikan cupang dapat menghasilkan sejumlah keuntungan yang dapat meningkatkan pendapatan
Pembelajaran IPA dengan Learning Cycle Berbantuan Multimedia Interaktif Ditinjau dari Pengetahuan Awal dan Gaya Belajar Siswa
Authors: Septian Damar
Published: June 2024

Penelitian ini bertujuan untuk mengetahui pengaruh pembelajaran IPA dengan model learning cycle berbantuan multimedia interaktif berbasis learning cycle antara siswa yang mempunyai pengetahuan awal tinggi dan rendah, antara siswa yang mempunyai gaya belajar visual dan kinestetik, serta interaksinya terhadap prestasi belajar kognitif siswa. Penelitian ini merupakan penelitian eksperimental. Populasi penelitian yaitu semua siswa kelas VIII SMP 7 Cirebon tahun pelajaran 2015/2016. Sampel diambil dengan teknik cluster random sampling sejumlah 2 kelas. Data dikumpulkan dengan metode tes tertulis untuk prestasi belajar kognitif dan pemahaman awal siswa serta metode angket untuk gaya belajar siswa. Teknik analisis data menggunakan analisis anava 2x2x2. Hasil pada penelitian ini adalah (1) ada pengaruh pembelajaran IPA dengan model learning cycle berbantuan multimedia interaktif berbasis learning cycle terhadap prestasi belajar kognitif siswa; (2) ada pengaruh pengetahuan awal terhadap prestasi belajar kognitif siswa; (3) tidak ada pengaruh gaya belajar terhadap prestasi belajar kognitif siswa; (4) ada interaksi antara model learning cycle berbantuan multimedia interaktif berbasis learning cycle dengan pengetahuan awal siswa terhadap prestasi belajar kognitif siswa pada pembelajaran IPA; (5) ada interaksi antara model learning cycle berbantuan multimedia interaktif berbasis learning cycle dengan gaya belajar siswa terhadap prestasi belajar kognitif siswa pada pembelajaran IPA; (6) tidak ada interaksi antara pengetahuan awal siswa dengan gaya belajar siswa terhadap prestasi belajar kognitif siswa pada pembelajaran IPA; (7) ada interaksi antara model learning cycle berbantuan multimedia interaktif berbasis learning cycle dengan pengetahuan awal dan gaya belajar siswa terhadap prestasi belajar kognitif siswa pada pembelajaran IPA.