bluuebunny/crossref_metadata_2025 huggingface dataset:
Plasma Phosphorylated Tau181 and Amyloid-β42 in Dementia with Lewy Bodies Compared with Alzheimer’s Disease and Cognitively Healthy People
Authors: Yu Yueyi , Xia Xinyi , Meng Xiaosheng , Li Dan , Qin Qi
Published: July 2023

Background:

Increasing evidence illustrates the value of plasma biomarkers of Alzheimer’s disease (AD) to screen for and identify dementia with Lewy bodies (DLB). However, confirmatory studies are needed to demonstrate the feasibility of these markers.

Objective:

To determine the feasibility of plasma tau phosphorylated at threonine 181 (p-tau181) and amyloid-β42 (Aβ42) as potential biomarkers to differentiate AD and DLB.

Methods:

We evaluated plasma samples from patients with DLB ( n = 47) and AD ( n = 55) and healthy controls (HCs, n = 30), using ELISAs to measure p-tau181 and Aβ42. Additionally, we examined neuropsychological assessment scores for participants. The plasma biomarkers were investigated for correlation with neuropsychological assessments and discriminant ability to identify DLB.

Results:

Plasma p-tau181 was significantly lower in DLB than in AD and HCs. Plasma Aβ42 was significantly higher in DLB than in AD but lower in DLB than in HCs. We found good correlations between plasma Aβ42 and neuropsychological scores in the whole cohort, while p-tau181 was associated with cognitive status in DLB. In the distinction between DLB and HCs, plasma p-tau181 and Aβ42 showed similar accuracy, while Aβ42 showed better accuracy than p-tau181 in discriminating DLB and AD.

Conclusion:

In a single-center clinical cohort, we confirmed the high diagnostic value of plasma p-tau181 and Aβ42 for distinguishing patients with DLB from HCs. Plasma Aβ42 improved the differential diagnosis of DLB from AD.
Shanghai Cognitive Screening: A Mobile Cognitive Assessment Tool Using Voice Recognition to Detect Mild Cognitive Impairment and Dementia in the Community
Authors: Huang Lin , Li Yatian , Wu Jingnan , Chen Nan , Xia Huanhuan , Guo Qihao
Published: July 2023

Background:

A rapid digital instrument is needed to facilitate community-based screening of mild cognitive impairment (MCI) and Alzheimer’s disease (AD) in China.

Objective:

We developed a voice recognition-based cognitive assessment (Shanghai Cognitive Screening, SCS) on mobile devices and evaluated its diagnostic performance.

Methods:

Participants (N = 251) including healthy controls (N = 98), subjective cognitive decline (SCD, N = 42), MCI (N = 80), and mild AD (N = 31) were recruited from the memory clinic at Shanghai Sixth People’s Hospital. The SCS is fully self-administered, takes about six minutes and measures the function of visual memory, language, and executive function. Participants were instructed to complete SCS tests, gold-standard neuropsychological tests and standardized structural 3T brain MRI.

Results:

The Cronbach’s alpha was 0.910 of the overall scale, indicating high internal consistency. The SCS total score had an AUC of 0.921 to detect AD (sensitivity = 0.903, specificity = 0.945, positive predictive value = 0.700, negative predictive value = 0.986, likelihood ratio = 16.42, number needed for screening utility = 0.639), and an AUC of 0.838 to detect MCI (sensitivity = 0.793, specificity = 0.671, positive predictive value = 0.657, negative predictive value = 0.803, likelihood ratio = 2.41, number needed for screening utility = 0.944). The subtests demonstrated moderate to high correlations with the gold-standard tests from their respective cognitive domains. The SCS total score and its memory scores all correlated positively with relative volumes of the whole hippocampus and almost all subregions, after controlling for age, sex, and education.

Conclusion:

The SCS has good diagnostic accuracy for detecting MCI and AD dementia and has the potential to facilitate large-scale screening in the general community.
Atractylenolide II ameliorates myocardial fibrosis and oxidative stress in spontaneous hypertension rats
Authors: Song Xiaolong , Wang Lei , Liu Min , Pan Renyou , Song Jun , Kong Junhong
Published: July 2023

BACKGROUND: Hypertension is a well-recognized risk factor for cardiovascular, which is also a critical factor in causing myocardial fibrosis (MF). OBJECTIVE: The study aimed to explore the effect of Atractylenolide II (ATL-II) on MF and oxidative stress in spontaneous hypertension rats (SHR). METHODS: The body weight of rats after injection of ATL-II was quantitatively analyzed. The left ventricular function of SHR was evaluated by Echocardiographic. HE staining, Masson trichrome staining, left ventricular mass index (LVMI) and immunofluorescence was applied to investigate the effects of ATL-II on MF. RT qPCR was used to detect the Collagen I, α-SMA, Fibronectin, and Vimentin mRNA expression levels in myocardial slices. The effect ATL-II on cardiomyocyte apoptosis was detected by TUNEL staining and western blot. An immunohistochemistry assay was conducted to detect α-SMA protein and TGF-β1 protein. The contents of H2O2, GSH-PX, SOD, and MDA were measured by colorimetry. RESULTS: ATL-II could dose-dependently improve the BW of SHRs (P< 0.05) and enhance myocardial function. Moreover, ATL-II effectively reduced cardiomyocyte apoptosis in SHRs. Alternatively, ATL-II could inhibit the Collagen I, α-SMA, Fibronectin, and Vimentin mRNA and protein expression levels in SHRs. ATL-II could ameliorate oxidative stress by improving the activities of SOD and GSH-PX and lowering the contents of H2O2 and MDA in ATL-II-treated SHRs, which reach about 80%. CONCLUSION: ATL-II could exert an inhibiting effect on MF and oxidative stress in SHRs. Hence, ATL-II may hold promise for the treatment of MF and oxidative stress in Spontaneous Hypertension.
Effect of additional dead space using end-tidal CO2 measurement on ventilating preterm infants: An experimental study
Authors: Mur Linda , Annon-Eberharter Natalee , Gombos Petra , Wald Martin
Published: July 2023

BACKGROUND: Dead space is the part of the airway where no gas exchange takes place. Any increase in dead space volume has a proportional effect on the required tidal volume and thus on the risk of ventilation-induced lung injury. Inserts that increase dead space are therefore not used in small preterm infants. This includes end-tidal CO2 measurement. OBJECTIVE: The aim of this study was to investigate the effect of the end-tidal CO2 measurement adapter on ventilation. METHODS: In an experimental setup, an end-tidal CO2 measurement adapter, three different pneumotachographs (PNT-A, PNT-B, PNT-Neo), and a closed suction adapter were combined in varying set-ups. The time required for CO2 elimination by a CO2-flooded preterm infant test lung was measured. RESULTS: PNT-A prolonged CO2 elimination time by 0.9 s (+3.3%), Neo-PNT by 3.2 s (+11.6%) and PNT-B by 9.0 s (+32.7%). The end-tidal CO2 measurement adapter prolonged the elimination time by an additional second without the pneumotachograph (+3.6%) and in combination with PNT-A (+3.1%) and PNT-Neo (+3.1%). In conjunction with PNT-B, the end-tidal CO2 measurement adapter reduced the elimination time by 0.3 seconds (-1%). The use of a closed suction adaptor increased the CO2 elimination time by a further second with PNT-Neo (+3.1%) and by an additional two seconds with no flow sensor (+6.9%), with PNT-A (+6.4%) and with PNT-B (+5.5%). CONCLUSION: The flow sensor had the greatest influence on ventilatory effort, while end-tidal CO2 measurement had only a moderate effect. The increased ventilatory effort levied by the CO2 measurement was dependent on the flow sensor selected. The use of closed suctioning more negatively impacted ventilatory effort than did end-tidal CO2 measurement.
Analysis of modified palatal surface for better speech in edentulous patients: A clinico-analytical study
Authors: Shukla Anuj K. , Chaturvedi Saurabh , Ahmed Abdul Razzaq , Abouzeid Hoda Lofty , Suleman Ghazala , Sharif Rania A. , Gurumurthy Vishwanath , Cicciù Marco , Minervini Giuseppe
Published: July 2023

BACKGROUND: Phonetics with mechanics and aesthetics are considered cardinal factors contributing to the success of complete dentures. OBJECTIVE: The aim of the current study was to evaluate the changes in speech in complete denture patients with and without palatal surface changes. METHODS: The data collected for the study involved completely edentulous Patients (n= 80). Patients were divided into two groups. Group A: Up to 50 years (n= 40); Group B: Above 50 years (n= 40) (including male and female). Each group was further divided into four subgroups for speech analysis-without dentures (A1/B1); with conventional dentures (A2/B2); dentures with a palatogram (A3/B3) and dentures with palate sandblasted (A4/B4). The speech sounds of all patients were evaluated for pitch and intensity using a spectrophotogram (Praat software) and Likert scale. The data so obtained from the quantitative and qualitative analysis were statistically analysed through one-way ANOVA, unpaired student’s t-test, and Pearson correlation coefficient. Qualitative analysis was done with the Mann-Whitney U test. RESULTS: The maximum mean value of the pitch and intensity in Groups A and B was subgroup A3 (Palatogram) 190.37 ± 21.50 and 77.07 ± 7.58, B3 (Palatogram) 190.87 ± 24.36 and 75.33 ± 8.12. When comparing Groups A [A1, A2, A3, A4] and B [B1, B2, B3, B4] on the basis of pitch and intensity, a statistically insignificant value was found. No changes in speech sounds (pitch and intensity) were observed in terms of age. Both quantitative and qualitative analysis results showed that speech sounds in the patients with palatogram, had the highest pitch and intensity and were most clear to the listener and there were statistically significant differences from other groups. CONCLUSION: Speech was better in palatogram-based dentures in comparison to a sandblasted denture, conventional denture and without denture in terms of qualitative and quantitative analysis. The physiologic nature of the palatogram fabrication technique produces the palatal part of the denture more compatible with the tongue, thus producing better speech.
Penerapan Strategi Bisnis di Era Digital yang Dikelola Ibu Rumah Tangga Untuk Meningkatkan Pendapatan Keluarga (Studi Kasus Komunitas Womenpreneur Karawang)
Authors: Triadinda Dexi , Hidayaty Dwi Epty
Published: July 2023

Peranan wanita khususnya ibu rumah tangga di era digital tidak lagi sebagai penonton di dunia bisnis, namun turut berperan dalam memberikan pendapatan bagi keluarga. Tujuan khusus penelitian ini adalah memperoleh gambaran strategi bisnis ibu rumah tangga di Kabupaten Karawang yang termasuk dalam komunitas womanpreneur di Era Digital. Batasan penelitian menggunakan teori strategi bersaing dari Michael Porter. Jenis penelitian ini adalah penelitian deskriptif kualitatif. Informan dalam peneltian terdiri dari tiga pengusaha wanita yang menekuni bisnisnya paling sedikit selama dua tahun kebelakang dan berdomisili di Kabupaten Karawang. Hasil dalam penelitian ini menunjukkan bahwa wanita memiliki peran penting dalam menungkatkan pendapatan keluarga melalui bisnis yang ditekuni. Disamping itu peran digitalisasi semakin memudahkan para pengusaha wanita dalam melakukan pemasaran dalam bisnis. The role of women, especially housewives in the digital era, is no longer as spectators in the business world, but also plays a role in providing income for the family. The specific objective of this study is to obtain an overview of the business strategies of housewives in Karawang Regency’s who are included in the womanpreneur community in the Digital Age. Limitation of research using competitive strategy theory from Michael Porter. This type of research is a qualitative descriptive research. The informants in the study consisted of three women entrepreneurs who had been in business for at least the past two years and were domiciled in Karawang Regency. The results in this study indicate that women have an important role in increasing family income through the business they are engaged in. Besides that, the role of digitization makes it easier for women entrepreneurs to do marketing in business.
Analisis Tingkat dan Sebaran Bencana Tanah Longsor di Kabupaten Bengkulu Tengah
Authors: Latif Muhammad , Andriani Andriani , Hakam Abdul
Published: July 2023

Pertemuan tiga lempeng terbesar di dunia antara lempeng Indo-Australia, lempeng Eurasia, dan lempeng Pasifik menyebabkan Indonesia menjadi wilayah yang berpotensi akan terjadinya bencana longsor. Longsor merupakan kejadian pergerakan suatu massa tanah atau geologi yang melalui suatu bidang gelicir yang menuruni lereng. Kabupaten Bengkulu Tengah yang berada di Provinsi Bengkulu, merupakan daerah rawan bencana longsor, hal ini dapat dilihat berdasarkan kejadian-kejadian terdahulu, yang telah menyebabkan masyarakat mengalami kerugian harta benda dan korban jiwa. Analisis sebaran longsor ialah sebuah cara yang digunakan untuk mengetahui wilayah dengan tingkat potensi terjadinya longsor mulai dari tingkat  rendah – sangat tinggi yang memungkinkan masyarakat dapat lebih waspada. Tujuan penelitian ini adalah  untuk mengetahui sebaran kerawanan longsor dan menentukan faktor dominan yang mempengaruhi tingkat potensi longsor. Metode penelitian dilakukan dengan pemberian bobot dan skoring dengan acuan Puslittanak. Pembuatan peta longsor ini di peroleh dari hasil overlay data-data sekunder seperti DEM, sebaran tutupan lahan, sebaran curah hujan, sebaran geologi, dan sebaran jenis tanah  yang menggunakan aplikasi ArcGIS 10.7. Hasil  penelitian diperoleh tingkat sebaran longsor di Kabupaten Bengkulu Tengah  didominasi oleh tingkat sebaran longsor yang sedang seluas 73455 Ha dengan persentase 60%. Daerah yang memiliki sebaran longsor sangat tinggi terdapat di empat kecamatan terdiri dari kecamatan Taba Penanjung, Meringgi Kelindang, Meringgi Sakti, dan Pematang Tiga seluas 8948 Ha dengan pesentase 7%. Sebaran peta curah hujan mempunyai nilai paling tinggi yang menjadi faktor paling dominan dalam proses terjadinya longsor.
The Relationship between Bodyweight, Maximum and Relative Strength, and Power Variables during Flywheel Inertial Training
Authors: Brien Joey O. , Browne Declan , Earls Des , Lodge Clare
Published: July 2023

The main aim of this study was to examine the relationship between body weight, absolute and relative strength and power variables in a flywheel Romanian deadlift. A secondary aim was to assess the inter-day reliability of a novel power assessment protocol previously used to determine the inertial load that produced the maximum power output in Flywheel Inertia Training. Ten physically active males took part in this study. Participants had some experience with flywheel devices, but all had a minimum of 24 months of traditional resistance training experience. The first testing session consisted of three sets of 10 repetitions with a different inertial load for each set (0.050, 0.075, and 1.00 kg·m2). Each set’s first and second repetitions were used to build momentum and were excluded from data analysis. The order of inertial load used in each trial was standardized for all participants: first, 0.050 kg·m2, second, 0.075 kg·m2, and last, 0.100 kg·m2. The secondary testing session followed the same procedure as the first. No statistically significant (p < 0.05) effect was found between any of the variables in the correlation analysis. There were large positive correlations between the 1 repetition max flywheel Romanian deadlift and peak concentric power, relative strength, and peak concentric and eccentric peak powers. Both body weight and relative strength showed moderate negative correlations with % eccentric overload, whereas moderate positive correlations were observed between 1RM and peak eccentric power. Both concentric power and eccentric power showed excellent reliability, while the reliability for % eccentric overload ranged from poor to excellent depending on the inertial load. In conclusion, this study shows that a protocol to assess the maximum power output has excellent reliability for both ECC and CON power and may be used in future flywheel training. The results also showed that body weight, maximum strength, and relative strength were not largely related to power variables. An individualized approach to flywheel training is required.
Calcium/P53/Ninjurin 1 Signaling Mediates Plasma Membrane Rupture of Acinar Cells in Severe Acute Pancreatitis
Authors: Lee Chehao , Xin Guang , Li Fan , Wan Chengyu , Yu Xiuxian , Feng Lijuan , Wen Ao , Cao Yu , Huang Wen
Published: July 2023

Ninjurin 1 (NINJ1) is a double-transmembrane cell-surface protein that might mediate plasma membrane rupture (PMR) and the diffusion of inflammatory factors. PMR is a characteristic of acinar cell injury in severe acute pancreatitis (SAP). However, the involvement of NINJ1 in mediating the PMR of acinar cells in SAP is currently unclear. Our study has shown that NINJ1 is expressed in acinar cells, and the expression is significantly upregulated in sodium-taurocholate-induced SAP. The knockout of NINJ1 delays PMR in acinar cells and alleviates SAP. Moreover, we observed that NINJ1 expression is mediated by Ca2+ concentration in acinar cells. Importantly, we found that Ca2+ overload drives mitochondrial stress to upregulate the P53/NINJ1 pathway, inducing PMR in acinar cells, and amlodipine, a Ca2+ channel inhibitor, can reduce the occurrence of PMR by decreasing the concentration of Ca2+. Our results demonstrate the mechanism by which NINJ1 induces PMR in SAP acinar cells and provide a potential new target for treatment of SAP.
Overview and Comparison of PLA Filaments Commercially Available in Europe for FFF Technology
Authors: Andronov Vladislav , Beránek Libor , Krůta Vojtěch , Hlavůňková Lucie , Jeníková Zdeňka
Published: July 2023

This study presents a comprehensive techno-economic analysis of PLA materials for fused filament fabrication (FFF) from eight European manufacturers. The comparison involved rigorous experimental assessments of the mechanical properties, dimensional accuracy, and print quality using standardized methods and equipment such as tensile and CT testing. What makes this study unique is the consistent methodology applied, considering factors such as material color, printing temperature, printing orientation, filament diameter, and printer selection, to ensure meaningful and reliable results. Contrary to the common belief that a higher price implies better quality, the study revealed that the second cheapest PLA material achieved the best overall performance within the methodology employed. The study also confirmed certain observations, such as the influence of printing orientation and geometry on dimensional accuracy and mechanical properties, as well as the significant disparities between manufacturer-provided values and actual measured mechanical properties, highlighting the importance of experimental verification. Hence, the findings of this study hold value not only for the scientific community but also for hobbyist printers and beginners in the 3D printing realm seeking guidance in material selection for their projects. Furthermore, the methodology employed in this research can be adapted for evaluating a broad range of other 3D printing materials.
Hydrothermal Effect on Ramie-Fiber-Reinforced Polymer Composite Plates: Water Uptake and Mechanical Properties
Authors: Wang Anni , Yin Peng , Liu Xiaogang , Xian Guijun
Published: July 2023

Ramie-fiber-reinforced polymer composites (RFRP) have the advantages of low price and low energy consumption, but they have high hydrophilicity due to their special chemical composition. In order to study the effect of water absorption on the performance degradation of RFRP in a hydrothermal environment, the authors prepared RFRP sheets by compression molding. Manufactured composites were exposed to a hydrothermal environment with a temperature of 40 °C and a humidity of 50% RH, 85% RH and 98% RH to study the water absorption and diffusion, mechanical properties (tensile properties, flexural properties and shear properties) of the RFRP, and their mechanical properties after drying. The research shows that the equilibrium moisture absorption rate of RFRP is mainly affected by the ambient humidity. The moisture absorption and diffusion of ramie-fiber-reinforced polymer composites (RFRP) in a hydrothermal environment conform to Fick’s law. Before reaching the moisture absorption equilibrium (1~2 weeks), the mechanical properties decline rapidly, and then tend to be flat, and the mechanical properties of the RFRP decrease significantly with the increase in humidity; the water molecules reduce the interfacial bonding performance and the modulus degradation degree of RFRP in the hydrothermal environment is greater than that of strength. After the samples were completely dried, the mechanical properties of the RFRP rebounded greatly, but less than the initial value, and the hydrothermal environment produced irreversible changes to the substrates.
DEVELOPMENT OF ALGEBRAIC THINKING SKILL TEST IN PROBLEM SOLVING OF FORM ONE LINEAR EQUATION
Authors: Jahudin Janet , Siew Nyet Moi
Published: July 2023

The Algebraic Thinking Test (ATT) Instrument was developed to measure algebraic thinking skills in solving problems involving the topic of linear equations. This study meant to determine the quality of ATT instruments through the validity and reliability analysis using the Rasch Measurement Model. ATT comprises of nine closed ended questions with three constructs of algebraic thinking namely: Generalized Arithmetic (GA), Functions (F) and Modeling (M). The sample consisted of 120 students aged 12 to 13 years from one rural area school in Tuaran district, Sabah. Validity analysis found that the polarity of the items through the PTMEA-Corr value indicated that all ten items were >0.00 (+). Through item suitability analysis, all items are still retained as they meet the requirements in the range of one of the MNSQ, Outfit ZSTD and PTMEA-Corr outfit. In the Principal Components Analysis (PCA), the Raw Variance Explained by Measures was found 61.1% (excellent) and the Unexplained variance value in the first contrast below 15% indicate that the instrument has a strong dimensionality and has high construct validity. The reliability of Cronbach Alpha (KR-20) demonstrated a value of 0.90 (very high), item reliability of 0.98 (excellent) and respondent 0.86 (good) with an isolation value of item 6.29 and respondent 2.45. In conclusion, ATT has good validity and high reliability in measuring algebraic thinking skills among form one students in secondary schools.
THE EFL JORDANIAN UNDERGRADUATES’ ATTITUDE TOWARDS THE USE OF PODCASTS IN TEACHING SPEAKING SKILLS IN JORDAN
Authors: Alshawabkah Abdel Fattah Kamel , Abdullah Ahmad Taufik Hidayah
Published: July 2023

Undoubtedly, English plays a vital role in ensuring flawless communication and interaction amongst people. Accordingly, this study aims at measuring the EFL Jordanian undergraduates’ attitude towards the use of podcasts in teaching speaking skills in Jordan. It also aims to identify the role of demographic information (Gender and Academic Year) of EFL Jordanian undergraduate students. In order to achieve such aims, this study adopted a quantitative research design by distributing a questionnaire. Accordingly, 284 questionnaires were analyzed. The findings concluded that students have positive attitude to improve their speaking skill with the help of podcast use. In addition, it is highlighted that this kind of use for podcast can improve vocabulary, pronunciation difficulties, grammar differences, listening difficulties, and other skills. It also found that students are significantly affected by the gender and academic year as the P.value is below 0.05. This study recommends conducting further studies focusing on the causes of speaking difficulties.
Tratamento ortodôntico-cirúrgico de incisivo central permanente impactado e com dilaceração severa: um tratamento desafiador
Authors: Nunes de Azevedo Monarko , Souza de Castro Livia , Moraes de Oliveira Lenza Milena , Beaton Lenza Eduardo
Published: July 2023

Objetivo: este relato de caso tem o objetivo de descrever o tratamento de um incisivo central superior impactado e com dilaceração radicular severa. Relato de caso: um paciente de 10 anos de idade procurou tratamento ortodôntico apresentando atraso na erupção do incisivo central superior esquerdo e histórico de traumatismo dentário na fase da dentição decídua. O diagnóstico foi feito por meio da avaliação clínica, radiografias e tomografia computadorizada de feixe cônico. O tratamento escolhido envolveu a exposição cirúrgica seguida de tracionamento do dente impactado com auxílio de aparelhos ortodônticos fixos. O tratamento ortodôntico foi concluído após 12 meses, resultando em um posicionamento adequado do incisivo central esquerdo no arco. Através de uma abordagem multidisciplinar foi possível posicionar o incisivo impactado no plano oclusal, preservando os tecidos periodontais e a vitalidade do dente. Conclusão: para os casos de dentes impactados, a abordagem multidisciplinar que envolve o tratamento ortodôntico-cirúrgico é a melhor opção para se obter um resultado satisfatório em termos de contorno gengival, plano oclusal e estética quando comparada com outras formas de tratamento.
La cittadinanza come politica pubblica tra ius sanguinis, ius soli e ius culturae
Authors: Corsi Cecilia
Published: July 2023

The contribution aims to offer a critical analysis of the Italian discipline on the ways of acquiring citizenship. The paper analyzes the most problematic aspects of the 1992 law, showing its anachronisms and unreasonableness, and then highlights the profiles that most need reform. In particular, the status of the minor born or schooled in Italy and the naturalization procedure claim a profound revision.
Fiebre de dengue en el Perú
Authors: Gutiérrez Tudela James Walter
Published: July 2023

El dengue es una enfermedad febril aguda causada por los arbovirus del género Flavivirus. Arbovirus es un acrónimo en inglés que significa “Arthropod-borne virus” (virus transmitidos por artrópodos) pero ya es un término aceptado también en español para describir los virus transmitidos al hombre por la picadura de vectores artrópodos hematófagos. Existen más de 500 arbovirus, de los cuales alrededor de 100 están relacionados con enfermedades en humanos y animales y sólo 4 familias están asociadas con enfermedades en seres humanos: Togaviridae, Flaviviridae, Bunyaviridae y Arenaviridae.
Verifikasi Metode Uji Lemak Pakan Buatan
Authors: Asmariani Asmariani , Amriani Amriani , Haslianti Haslianti
Published: July 2023

Verification method is required to generate data analysis with accurate and precise value corresponding to the standrad method. This study aims to verify fat analysis method by using direct extraction method. The study was conducted in Laboratorium Pengujian, FPIK, Universitas Halu Oleo. Fat analysis method verified was direct extraction method or soxhlet method. The results showed that all precision values from experiments I-VIII, consisting of repeatability and reproductibility, have RSD values (0.03 â€“ 0.14) lower than 2/3 RSD Horwitz (1.99). The accuracy results (% Recovery) indicated similarly RSD, lower than 2/3 RSD Horwitz (1.33). Based on these results, it can be concluded that fat analysis method used in Laboratorium Pengujian, meet the pecise and accuray standard, and generates valid data and accounted for.
PENTINGNYA IMPLEMENTASI NILAI PANCASILA SILA KESATU DALAM MENUMBUHKAN KARAKTER SISWA SEKOLAH DASAR – ANALISIS STUDI PUSTAKA
Authors: Diana Aliansyah Sopia  , Mayang Avrilla  , Robi Anawiyah Sya’bani
Published: July 2023

The application of Pancasila values ​​is very important in developing the character of elementary school students in everyday life. The application of the values ​​in the first precepts of Pancasila is based on "Belief in the One and Only God". The purpose of this study was to find out how the implementation of Pancasila values ​​in the first precepts among elementary school students. The research method used was literature study with 15 journal articles reviewed. The results show that the application of the first Pancasila values ​​is very important in growing the character of elementary school students. Where the character can be formed in a short time. The role of parents and teachers is very influential in the implementation of the implementation of Pancasila values, especially the first precepts in students' daily lives.
HUBUNGAN DUKUNGAN KELUARGA TERHADAP KEPATUHAN MINUM OBAT PADA PASIEN TUBERKULOSIS PARU
Authors: Jumari
Published: July 2023

Latar Belakang TBC (Tuberkulosis) yaitu suatu penyakit yang diakibatkan oleh infeksi Mycobacterium Tuberculosis. Secara global berdasarkan data World Health Organization (WHO) pada tahun 2016 terdapat 10,4 juta kasus insiden TBC (8,8 juta-12, juta) yang setara dengan 120 kasus per 100.000 penduduk. Lima negara dengan insiden kasus tertinggi yaitu India, Indonesia, China, Philipina, dan Pakistan. Profil Kesehatan Kementrian Kesehatan Republik Indonesia tahun 2016 mengatakan jumlah kasus TBC di Indonesia tertinggi di provinsi Jawa Barat sebanyak 52.328 kasus Berdasarkan data tersebut bahwa Daerah Khusus Ibukota Jakarta peringkat ketiga kasus TBC terbanyak di Indonesia yaitu sebesar 24.775 kasus. Dengan adanya dukungan keluarga/orang terdekat diharapkan sangat menunjang keberhasilan pengobatan seseorang dengan selalu mengingatkan penderita agar tetap rajin berobat.

Tujuan Penulisan : Untuk mengetahui hubungan dukungan keluarga terhadap kepatuhan minum obat pada pasien TB paru di Poli DOTS Rumah Sakit Umum Daerah Pademangan tahun 2020

Metode Penelitian :Desain penelitian ini adalah survei analitik dengan pendekatan Cross Sectional. Sampel berjumlah 71 pasien TB Paru diruang Poli TB DOTS. Tehnik pengumpulan sampel dengan menggunakan metode Purposive sampling. Tehnik pengumpulan data penelitian menggunakan data primer yang diambil langsung dari responden /informan denngan menggunakan kuesioner. Pengelolahan data menggunakan komputerisasi SPSS 25.0. Analisis yang digunakan adalah Univariat dan Bivariat (Chi- square) menggunakan batas kemaknaan Alpa = < 0,05

Hasil Penelitian : Hasil penelitian ini menunjukkan bahwa ada hubungan yang signifikan antara dukungan keluarga dengan kepatuhan minum obat pasien TB paru ( P = 0.000)

Kesimpulan : Dari ketiga variabel terdapat ada hubungan dukungan keluarga terhadap kepatuhan minum obat pada pasien TB Paru di Poli DOTS RSUD
Características epidemiológicas de la hernia diafragmática diagnosticada en la edad adulta.
Authors: Pérez Salcedo Fernando Rafael , Madrid Albertzy Francisco David , Ortíz Patrón María alejandra , Mahuad Suárez Jessica Marcela , Fuentes De Oro Nacira , Garcia Romero Alvaro Guillermo , Araújo Rodríguez Robinson Antolín , Pérez Villalba Víctor Daniel
Published: July 2023

La hernia diafragmática se define como la protrusión de vísceras abdominales hacia el tórax a través de un defecto en el diafragma, asociado a un cambio en el gradiente de presiones entre estas dos cavidades. Esta es una patología rara en el adulto, que puede ser de origen congénito o adquirido, siendo este último la etiología más frecuente. Las causas principales de la misma son traumatismos cerrados o abiertos, ya sea por accidentes de tránsito, caídas a grandes alturas, heridas por arma de fuego o cortopunzantes. Es por esto por lo que suelen presentarse con mayor frecuencia en hombres jóvenes. Debido a la distribución de los órganos abdominales, se presentan con mayor frecuencia en el hemidiafragma izquierdo ya que no cuentan con la protección del hígado y diversos estudios muestran una disminución en el grosor del músculo en este lado. Debido a la localización, las vísceras más comúnmente evidenciadas son: estómago, intestino, bazo y páncreas. Las manifestaciones clínicas de esta patología son inespecíficas por lo que comúnmente se diagnostican de forma incidental al explorar otras patologías, sin embargo puede tener complicaciones fatales secundarias al estrangulamiento de las vísceras herniadas. Su abordaje en todos los casos es quirúrgico y depende de los factores individuales de cada paciente y de la decisión del cirujano la elección de un procedimiento abdominal o torácico.  Debido a la mortalidad asociada a las complicaciones de esta patología surge la necesidad de conocer la epidemiología y establecer una sospecha clínica para lograr un diagnóstico y tratamiento temprano.
Characteristics, Clinical Manifestations, Length of Hospitalization, and Nutritional Status of COVID-19 Patients
Authors: Wardani Erika Martining , Nugroho Riezky Faisal , Bistara Difran Nobel , Wijayanti Lono , Nurhasina Siti , Cahyaningsih Fety Susanti
Published: July 2023

BACKGROUND: The disease that is endemic and has become a global pandemic is COVID-19 due to reports of thousands of cases. The pandemic is weighing on intensive care units with an influx of COVID-19 patients. The clinical manifestations of COVID-19 vary, diagnostic examinations and treatment are also experiencing dynamic developments. This study aims to provide an overview  of the characteristics, clinical manifestations, length of treatment, and nutritional status of COVID-19 patients.
METHODS: This study used a descriptive analytic cross-sectional method with inclusion criteria that were positive for COVID-19. The research data were obtained from 130 hospital medical records for the period June to August 2021. The collected data were then analyzed using SPSS.
RESULTS: The study found that men were more exposed to COVID-19 (71.5%) and 70% of patients worked as medical personnel. The age  range of the majority of patients was more than 40 years (78.5%). Most of the comorbidities were hypertensive patients. Clinical manifestations of COVID-19 patients were cough (44.6%), fever (40%), flu-like symptoms (32.3%), painful swallowing (26.2%), anosmia (16.2%), shortness of  breath (15.4%), nausea (14.6%), vomiting (13.8%), and diarrhea (0.9%). The average length of stay is 7–14 days (9.2%) with adequate nutritional status (14.6%). Patients with length of treatment (p = 0.01) and poor nutritional status (p =0.000) were significantly different.
CONCLUSION: The majority of COVID-19 sufferers are male, over 40 years old, with cough symptoms, and the most comorbid hypertension, as well as deaths from hypertension and the elderly. Better treatment is needed for people with COVID-19.
An unusually high prevalence of isolated prostatic ductal adenocarcinoma among Saudi patients: A registry-based study
Authors: Alasker Ahmed , Alghafees Mohammad , Chaudhri Eman N. , Al Qurashi Abdullah A. , Abdul Rab Saleha , Sabbah Belal N. , Musalli Ziyad , Alyami Ali
Published: July 2023

Objective:

We conduct a secondary analysis on the demographics, tumor characteristics, survival, and risk factors for mortality among patients with prostatic ductal adenocarcinoma (PDA) in the Kingdom of Saudi Arabia (KSA).

Methods:

This is a registry-based retrospective study that included all patients diagnosed with prostate cancer in the KSA. The data were collected from the Saudi Cancer Registry, which collects tumor data from all private, military, and health ministry hospitals in Saudi Arabia through five regional offices.

Results:

Among 3607 prostate cancer patients detected during the specified period, 209 (5.8%) had ductal adenocarcinoma. The median interquartile range age of patients was 72.0 years (64.0–78.0). Adenocarcinoma lesions were malignant among all the patients. Grade III tumors were most frequently apparent lesions (61.2%), followed by Grade II tumors (26.3%), Grade I tumors (7.2%), and Grade VI tumors (5.3%). A total of 33 patients died, representing 15.8% of the whole sample. The 1-year survival rate was 78.1%. More than a third of patients who were residing in the Western region deceased (38.0%), whereas no deaths were reported in other regions with a statistically significant difference based on regions (P < 0.001).

Conclusion:

To the best of our knowledge, this is the first registry-based study to investigate PDA in the KSA; these efforts were done to further understand this deadly condition and to further enhance patient care in the KSA.
Did Covid-19 reshape constructivism approach? A synthesis paper during the world-wide shift to full distance learning
Authors: Pacala Frank Angelo , Obiedo Rolando
Published: July 2023

The Covid-19 pandemic had a profound effect on the use of constructivism in learning. As schools and learning institutions around the world were forced to transition to online classrooms, teachers had to find new ways to reach their students and engage them in an educational environment. This study was conducted to synthesize the various researches about the impact of a pandemic on the constructivism theory of learning. This paper used the general principle of constructivism to conduct the synthesis review. The findings indicated that there was disruption in student engagement but collaboration among students was maintained. Also, the process of lesson contextualization was interrupted as classes were moved to online platforms. Teachers have used various tools to check the integrity of the students’ outputs and literature suggest that outputs have been upright and reliable. The support of the parents to the learning of the students was perceived to be enhanced. Hence, the constructivism approach was taken to a new level and was truly reshaped by the pandemic.
Digitizing the Culicidae collection of Naturalis Biodiversity Center, with a special focus on the former Bonne-Wepster subcollection
Authors: Ciliberti Pasquale , Roquas Astrid , Desjardins Becky , Berkholst Bibiche , Loggen Frank , Hooft Menno , Gijswijt Gideon , de Graaff Dick
Published: July 2023

Natural history collections contain a wealth of information on species diversity, distribution and ecology. However, due to historical and practical constraints, this valuable information is not always available to researchers. Our project aimed at unlocking data handwritten in notebooks owned by Johanna Bonne-Wepster, a Culicidae researcher. These handwritten notes refer to specimens labeled with a number only. The notebooks were scanned and entered into a Google spreadsheet. The specimens were provided with a unique identifier, labeled with the information from the notebooks and the data exported to the Global Biodiversity Information Facility. In addition, the type specimens were photographed. Besides Johanna Bonne-Wepster’s collection, mosquitoes from the former Rijksmuseum van Natuurlijk Historie collection and the former Zoölogisch Museum Amsterdam Nederland collection were digitized. All specimens are now housed at the Naturalis Biodiversity Center museum in Leiden. This paper describes the efforts to mobilize this data and the problems we encountered.
Cyber Security of the System of Electronic Payment of the National Bank of Ukraine
Authors: Vyhovska Nataliia
Published: July 2023

"In the world of today, cases of cyber attacks on banking systems have become more frequent. The aim of this research is to develop methodical and practical recommendations how to eliminate threats of oversight of payment systems, stabilize the protection of participants and users of the payment portfolio of banking institutions against misinformation and fraud. The research proposes a synergistic cyber security model of the SEP of NBU, taking into account the securitization of the payment portfolio of banking institutions in the financial market to prevent threats and meet the needs of participants and users in banking services. The article analyzes the chronology of attacks on the information resources of the NBU and the banking system during the period of martial law in Ukraine, and presents fraudulent targeted attacks “using eidetic of banking institutions of Ukraine. The criteria for the level of cyber security of the SEP of NBU are recommended. The research concludes with a determination of the reference state bank of Ukraine, which has the best combination of the level of securitization of the payment portfolio of banking institutions and the protection of active information resources. The practical significance of this research lies in providing recommendations aimed at improving the stability of cyber security in the SEP of NBU, thereby ensuring the safety of cash transactions in the digital economy."
The Impact of Small and Medium-Sized Enterprises on the Level of Employment
Authors: Aliyev Teyyub
Published: July 2023

"For any country, an important component of its national well-being is ensuring the working capacity of the population. Since the problem of unemployment is one of the most common in Azerbaijan, it is relevant to consider it in the country. The experience of developed countries shows that small and medium-sized enterprises play an important role in providing employment. Therefore, it is relevant to consider the current state of this type of business in the country and identify the degree of its influence on the level of employment. The main methods that were used during the study were analysis, induction, modelling, forecasting. Thus, it was shown that there is a direct interdependence between the state of small and medium-sized enterprises and the level of employment, which indicates the need for the development of this type of business to solve problems related to the labour market. In addition, some difficulties were presented that hinder the qualitative development of this type of business. Among them are problems in legislation, difficulties with financing, institutional imperfection. In addition, the authors propose some methods of solving them, in particular, the introduction of changes in monetary policy, ensuring state financing of small and medium-sized enterprises, changing legislation. The study makes a certain contribution to the development of the theory of economic analysis (highlighting the impact of small and medium-sized businesses on employment in Azerbaijan)."
The Military Economy of Israel: How much does a global security system cost?
Authors: Semenenko Oleh
Published: July 2023

"The purpose of the article is to study the development of the Israel’s defence complex, determine the cost of its provision, analyse the ways to achieve high military efficiency and further prospects. The following scientific methods were used in the course of the study: historical method, rating method, analysis, synthesis, comparison method, graphical methods, method of establishing the cause-and-effect relationships. As a result of the study, it has been established the prerequisites, causes and course of the Arab-Israeli conflict, in which Israel has been developing over the past century. The place of Israel in the ranking of countries in terms of military strength was determined, and the detailed analysis of the country’s military expenditures as a percentage of its GDP was carried out. It has been compared the data obtained on the results of the countries’ region, which are actual or potential opponents of Israel, as well as individual countries of the world and the “Group of Twenty”. It has been investigated the trends of Israel’s military expenditures compared to its expenditures on the scientific-research and experimental-design works (SREDW)."
DIFERENTES METÓDOS TERAPÊUTICOS RELACIONADOS À PERI-IMPLANTITE: UMA VISÃO GERAL DE REVISÕES SISTEMÁTICAS
Authors: Rodrigues de Melo Silva Paula Fernanda , Miranda Tamires Szeremeske de , Santos Nidia Cristina Castro dos , Shibli Jamil Awad , Rodrigues Jose Augusto , Figueiredo Luciene Cristina
Published: July 2023

As doenças peri-implantares são definidas como lesões inflamatórias dos tecidos que circundam os implantes dentários, abrangendo a mucosite peri-implantar e a peri-implantite. O objetivo deste trabalho foi avaliar as revisões sistemáticas publicadas em periódicos indexados sobre os diversos tipos de tratamento para a peri-implantite. Uma visão geral de revisões sistemáticas (Umbrella Review) foi realizada através da avaliação de periódicos publicados em banco de dados eletrônicos (PubMed, Cochrane, MEDLINE, LILACS, Science Direct), utilizando os descritores: Peri-implantite OU Doença Peri-implantar OU Infecção peri-implantar E Tratamento peri-implantar OU Terapia peri-implantar, sem restrição de idiomas, entre 2011 e 2022. Também foi realizada uma estratégia de busca manual específica nas referências dos artigos selecionados. Quarenta e oito artigos foram encontrados, destes, 34 artigos foram eleitos para compor esse estudo. Foram excluídos relatos de casos, estudos observacionais, ensaios clínicos randomizados ou não randomizados, estudos experimentais, comentários, resumos expandidos, e estudos em duplicata. A terapia peri-implantar não cirúrgica envolve o debridamento mecânico da superfície do implante usando curetas, dispositivos ultrassônicos ou abrasivos a ar ou lasers, com ou sem o uso adjuvante de antibióticos ou antissépticos locais. A eficácia das diversas terapias peri-implantares mostrou‐se limitada, inclusive para a associação de antimicrobianos, especialmente em termos de redução da profundidade de sondagem e ganho de tecido ósseo. Dessa forma, sugere-se a necessidade da realização de novas revisões sistemáticas com melhor delineamento metodológico e mínimo de vieses. Assim, resultados mais previsíveis serão alcançados e promoverão uma maior confiança na escolha da forma terapêutica ideal para cada situação clínica.
HYALURONIC ACID USING THE “FERN PATTERN TECHNIQUE” TECHNIQUE - SLEEP WRINKLES TREATMENT
Authors: Chiarelli Murillo , Januzzi Marcelo
Published: July 2023

The skin, due to its protective role, suffers from exogenous factors (ultraviolet radiation, pollution and trauma) and endogenous factors (endocrine-metabolic diseases, alcohol and tobacco use), a sequence of functional alterations and/or structural problems that could harm its integrity, leading to dyschromia, dehydration, loss of elasticity and microvascular alterations. Wrinkles are an indicator of facial aging, with fault lines occurring in the skin, due to skin distortions resulting from facial expression or mechanical movements and compressions during sleep. Expression and sleep wrinkles differ in etiology, location and anatomical pattern. The skin during sleep undergoes compression, shear and tension forces that act on the face when we are in lateral or prone sleeping positions. Hyaluronic acid, since the 1990s, has been employed as a favorable temporary filler option for facial augmentation and for the regulation of various biological processes, such as skin repair, wound healing, tissue regeneration, reaching the prominent place regarding the treatment of wrinkles. This work aims to report a case of treatment of sleep wrinkles, in a female patient, only treated with fillers based on hyaluronic acid, with the “Fern Pattern Technique” technique with evolution of 2 years and with a single application.
SO SÁNH HIỆU QUẢ CỦA CHU KỲ CHUYỂN PHÔI ĐÔNG LẠNH CHUẨN BỊ BẰNG PHÁC ĐỒ TỰ NHIÊN VÀ PHÁC ĐỒ NGOẠI SINH
Authors: Hoàng Thị Thu Hà , Dương Tiến Tùng , Trần Phương Anh , Trần Khánh Linh , Nguyễn Anh Đào , Lê Ngọc Dung , Nguyễn Khang Sơn
Published: July 2023

Mục tiêu: Đánh giá kết quả có thai của chu kỳ chuyển phôi đông lạnh được chuẩn bị bằng phác đồ tự nhiên và phác đồ ngoại sinh. Phương pháp: Mô tả hồi cứu trên 86 bệnh nhân chuyển phôi đông lạnh được chuẩn bị niêm mạc bằng một trong hai phác đồ, trong thời gian từ tháng 12/2022 tới tháng 3/2023, tại Trung tâm Hỗ trợ sinh sản và Công nghệ mô ghép, Bệnh viện Đại học Y Hà Nội. Kết quả: Độ dày niêm mạc tử cung tại thời điểm kết thúc pha tăng sinh không có sự khác biệt giữa hai phác đồ. Không có sự khác biệt có ý nghĩa thống kê về tỉ lệ có thai của phác đồ tự nhiên (65.7%) và phác đồ ngoại sinh (68.6%). Kết luận: Chuẩn bị niêm mạc tử cung bằng phác đồ tự nhiên là phương pháp sinh lý, hiệu quả với tỉ lệ có thai tương đương với phác đồ ngoại sinh.