bluuebunny/crossref_metadata_2025 huggingface dataset:
The Relationship between Metabolic Syndrome and Plasma Metals Modified by EGFR and TNF-α Gene Polymorphisms
Authors: Chen Tzu-Hua , Kung Wei-Shyang , Sun Hung-Yu , Huang Joh-Jong , Lu Jia-Yi , Luo Kuei-Hau , Chuang Hung-Yi
Published: September 2021

With the escalating global prevalence of metabolic syndrome (MetS), it is crucial to detect the high-risk population early and to prevent chronic diseases. Exposure to various metals has been indicated to promote MetS, but the findings were controversial, and the effect of genetic modification was not considered. Epidermal growth factor receptor (EGFR) was proposed to be involved in the pathway of metabolic disorders, and tumor necrotic factor-α (TNF-α) was regarded as an early inflammatory biomarker for MetS. This research aimed to analyze the impact of EGFR and TNF-α gene polymorphisms on the prevalence of MetS under environmental or occupational exposure to metals. We gathered data from 376 metal industrial workers and 639 non-metal workers, including physical parameters, biochemical data, and plasma concentrations of six metals. According to the genomic database of Taiwan Biobank, 23 single nucleotide polymorphisms (SNPs) on EGFR gene and 6 SNPs on TNF-α gene were incorporated in our research. We applied multivariable logistic regression to analyze the probability of MetS with various SNPs and metals. Our study revealed some susceptible and protective EGFR and TNF-α genotypes under excessive exposure to cobalt, zinc, selenium, and lead. Thus, we remind the high-risk population of taking measures to prevent MetS.
Short-Term Exposure to Wood Smoke Increases the Expression of Pro-Inflammatory Cytokines, Gelatinases, and TIMPs in Guinea Pigs
Authors: Ramos Carlos , Cañedo-Mondragón Rebeca , Becerril Carina , González-Ávila Georgina , Esquivel Ana Laura , Torres-Machorro Ana Lilia , Montaño Martha
Published: September 2021

Exposure to air pollutants in wildfire smoke and indoor pollution causes lung diseases. Short-term exposure to wood smoke (WS) is partially known to alter the expression of human matrix metalloproteinases (MMPs), inflammatory cytokines, and tissue inhibitors of metalloproteinases (TIMPs). Accordingly, we investigated the effect of exposing guinea pigs to WS for two and four three-hour periods on different days. The daily content of particles reported by indoor pollution was produced by 60 g of pinewood. We analyzed the cell profile and collagen content in bronchoalveolar lavages (BAL). The mRNA expression of pro-inflammatory cytokines, MMPs, and TIMPs was studied in lung tissue. Cytokines and gelatinolytic activity were analyzed in BAL and serum. The results showed that total cells, macrophages, neutrophils, and collagen increased in BAL, whereas neutrophils and lymphocytes decreased. TGF-β1, TNF-α, IFN-γ, IL-1β, IL-6, IL-8, MMP-2, MMP-9, TIMP-1, and TIMP-2 were upregulated in lungs, downregulating IL-12. TNF-α, IFN-γ, TGF-β1, IL-1β, IL-6, and IL-8 were increased in BAL and serum, decreasing IL-12. Gelatinase activity was increased in serum. Thus, guinea pigs exposed to short-term domestic doses of WS overexpressed pro-inflammatory cytokines, MMPs, and TIMPs. These results are similar to ECM remodeling and pulmonary and systemic inflammation reported in humans.
Screening for Parasitic Infection and Tuberculosis in Immunosuppressed and Pre-Immunosuppressed Patients: An Observational Study
Authors: Carnino Luisa , Schwob Jean-Marc , Neofytos Dionysios , Lazo-Porras Maria , Chappuis François , Eperon Gilles
Published: September 2021

Reactivation of latent tuberculosis infection (LTBI) or latent parasitic infection (LPI) during drug-induced immunosuppression can have serious consequences. The Division of tropical and humanitarian medicine of the Geneva University Hospitals runs a specific consultation for parasitic screening of immunosuppressed or pre-immunosuppressed patients. We sought to determine the seroprevalence of LTBI and LPI in such patients and explore its relationship with country of origin or previous travel in a retrospective, single-centre observational study from 2016 to 2019. Demographic data, travel history, ongoing treatments and results of the parasitological (Strongyloides stercoralis, Trypanosoma cruzi, Echinococcus multilocularis, Entamoeba histolytica and Leishmania spp.) and TB screening were collected to calculate LPI or LTBI prevalence. Risk factors for LTBI and strongyloidiasis were analysed using Poisson regression with robust variance. Among 406 eligible patients, 24/353 (6.8%) had LTBI, 8/368 (2.2%) were positive for Strongyloides stercoralis infection, 1/32 (3.1%) was positive for Entamoeba histolytica and 1/299 (0.3%) was positive for Leishmaniasis. No cases of Trypanosoma cruzi (0/274) or Echinococcus multilocularis (0/56) infection were detected. Previous travel to or originating from high-prevalence countries was a risk factor for LTBI (PR = 3.4, CI 95%: 1.4–8.2 and 4.0, CI 95%: 1.8–8.9, respectively). The prevalence of serological Strongyloidiasis in immunosuppressed patients is lower in comparison to those without immunosuppression (PR = 0.1, CI 95%: 0.01–0.8). In conclusion, screening before immunosuppression needs to be individualized, and LTBI and LPI need to be ruled out in patients who originate from or have travelled to high-prevalence countries. The sensitivity of strongyloidiasis serology is reduced following immunosuppression, so an algorithm combining different tests or presumptive treatment should be considered.
Evolution of Neutron Star Magnetic Fields
Authors: Igoshev Andrei P. , Popov Sergei B. , Hollerbach Rainer
Published: September 2021

Neutron stars are natural physical laboratories allowing us to study a plethora of phenomena in extreme conditions. In particular, these compact objects can have very strong magnetic fields with non-trivial origin and evolution. In many respects, its magnetic field determines the appearance of a neutron star. Thus, understanding the field properties is important for the interpretation of observational data. Complementing this, observations of diverse kinds of neutron stars enable us to probe parameters of electro-dynamical processes at scales unavailable in terrestrial laboratories. In this review, we first briefly describe theoretical models of the formation and evolution of the magnetic field of neutron stars, paying special attention to field decay processes. Then, we present important observational results related to the field properties of different types of compact objects: magnetars, cooling neutron stars, radio pulsars, and sources in binary systems. After that, we discuss which observations can shed light on the obscure characteristics of neutron star magnetic fields and their behaviour. We end the review with a subjective list of open problems.
“Vaccinate, Do Not Hesitate!”. Vaccination Readiness against COVID-19 among Polish Nursing Undergraduate Students: A National Cross-Sectional Survey
Authors: Gotlib Joanna , Sobierajski Tomasz , Jaworski Mariusz , Wawrzuta Dominik , Borowiak Ewa , Dobrowolska Beata , Dyk Danuta , Gaworska-Krzemińska Aleksandra , Grochans Elżbieta , Kózka Maria , Kulik Halina , Lewko Jolanta , Nowak-Starz Grażyna , Wojciechowska Małgorzata , Uchmanowicz Izabella , Panczyk Mariusz
Published: September 2021

COVID-19 vaccination raises numerous concerns among the public, and also among medical personnel including nurses. As nurses play a crucial role in the process of vaccination, it is important to recognize the attitudes of students of nursing, nurses in spe, toward COVID-19 vaccination, as well as to define the factors influencing students’ pro-vaccine choices. The study was conducted between March and April 2021 at all medical universities in Poland educating nurses in spe. The study included 793 first-degree students from 12 universities. The results revealed that the vast majority of students of nursing (77.2%) were vaccinated against COVID-19, as 61.2% received an mRNA vaccine and 16% a viral vector vaccine. Every other person in the non-vaccinated group declared their intention to get a vaccination. A trend was observed whereby people co-living with persons from the risk group, who are at risk of a severe form of COVID-19, showed greater willingness to get a vaccine. The study results identified the role of universities in increasing the vaccination rate among students, both in terms of education about vaccinations and in shaping pro-vaccine attitudes among students, as well as organizing vaccinations on university campuses to facilitate the process.
Advances in Vaccine Development
Authors: Tripp Ralph A.
Published: September 2021

The Special Issue titled “Advances in Vaccine Development” contains articles, reviews, and a perspective on advances in vaccine delivery and expression, nanovaccines, epitopes, proteins and adjuvants, and new vaccine platforms [...]
Melatonin as Immune Potentiator for Enhancing Subunit Vaccine Efficacy against Bovine Viral Diarrhea Virus
Authors: Wang Yi-Xuan , Yang Guang-Hui , Zhang Lin-Lin , Wang Jing , Wang Jiu-Feng
Published: September 2021

Bovine viral diarrhea virus (BVDV) is a pathogen associated with substantial economic losses in the dairy cattle industry. Currently, there are no effective vaccines against BVDV. Melatonin (MT) has been shown to have anti-inflammatory and anti-viral properties, and the use of MF59 in vaccines significantly enhances vaccine efficiency. Here, MT and MF59 were added into the Erns-LTB vaccine. Subsequently, their inhibitory activity on the NF-κB signaling pathway in Mardin-Darby Bovine Kidney cells and the hippocampus was assessed using western blot and quantitative reverse transcription PCR. The findings revealed that MT in the Erns-LTB vaccine decreases the phosphorylation of p65 proteins caused by BVDV infection. In addition, MT decreased the mRNA levels of IL-1β and IL-6 in vitro, but increased the production of IFN-α, IFN-β, Mx1 in vitro, brain-derived neurotrophic factor, cyclic amp response element-binding protein, and the stem cell factor in vivo. Furthermore, treatment with Erns-LTB + MF59 + MT stimulated the production of T lymphocytes, alleviated pathological damage, decreased expressions of BVDV antigen, and tight junction proteins in mice. These findings imply that MT has potential for use in the Erns-LTB vaccine to inhibit BVDV infection and regulate the immune responses of T-cells by inhibiting the NF-κB signaling pathway.
Veterinary Chiropractic Treatment as a Measure to Prevent the Occurrence of Spondylosis in Boxers
Authors: Halle Kristin Steinmoen , Granhus Aksel
Published: September 2021

Spondylosis deformans is a spinal disease common to several dog breeds, and several treatments including veterinary chiropractic may be used to treat affected dogs. Little is known, however, about the efficacy of chiropractic treatment as precautionary measure, aiming to reduce the probability of spondylosis development. We performed a randomized study where one half of the Boxer puppies from 17 litters were given veterinary chiropractic treatment at monthly intervals from eight weeks of age until they were one year old, while the other half were given no treatment (treated: n = 44, controls: n = 43). At an age of one year, spondylosis occurrence was recorded based on a scoring of X-ray images of the spine. The frequency of occurrence was significantly lower (p = 0.0478) in the treated dogs (25.0%) than in the controls (46.5%). We also tested if spondylosis occurrence in the treated dogs correlated with the average number of spinal joints with decreased mobility found per chiropractic treatment. No such effect was found, however. In summary, our results suggest that veterinary chiropractic treatment may be successfully used to reduce the probability of early development of spondylosis in young Boxers.
Unravelling the Temporal-Spatial Distribution of the Agricultural Water Footprint in the Yangtze River Basin (YRB) of China
Authors: Zeng Wen , He Junchen , Qiu Yaliu , Cao Xinchun
Published: September 2021

Quantification of the relationship between agricultural water use and social development is important for the balance between conserving water resources and sustainable economic development. The agricultural water footprint (AWF) from crop production across 11 provinces in the Yangtze River Basin (YRB) of China, from 1999 to 2018, was calculated in the current paper. The driving factors which affected the provincial AWF were revealed using the logarithmic mean Divisia index (LMDI) model, based on a temporal and spatial variation assessment. The results showed that, with a growth rate of 1.95% per year, the annual AWF of the in the basin was 441.6 Gm3 (green water accounted for 73.63% of this) in the observed two decades. The Jiangsu, Anhui, Hubei and Sichuan provinces jointly accounted for 54% of the total AWF of the region. Cereal, cotton and fruit crops contributed most of the AWF, and determined the trends of the AWF over time. With the development of the economy and market demand, the dominant crop contributing to the AWF has shifted, from cereal and cotton around 2000, to cereals and fruits at present. The economic level was the main contributing factor driving the AWF. However, water use intensity was the most important factor which inhibited the growth of the AWF. Irrigation technology and the degree of urbanization also played a certain inhibitory role. There were significant differences in the driving effects among the different provinces. A comprehensive evaluation of the AWF and analysis of its driving factors provides a solid foundation for optimizing planting structure, strengthening water resource management, and enhancing regional exchanges and cooperation.
Introduction of environmental controlling in the activities of an economic entity
Authors: Kostyukova E. I. , Khoruzhy L. I. , Tsiselskaya Yu. A.
Published: September 2021

The article discusses the theoretical and organizational and methodological aspects of the formation of environmental controlling in the work of the organization. The measures for the implementation of the eco-controlling program are designed to provide an economic entity with a single interconnected conceptual management structure of green progress. The study describes the tools for the effective and efficient use of environmental resources, in order to ensure environmental and economic sustainability.
Application of a digital automated system in the management of environmental accounting
Authors: Kostyukova E. I. , Mastepanenko M. A. , Tsiselskaya Yu. A.
Published: September 2021

The article considers a practical example of the introduction of a digital automated platform into the work of an economic entity within the framework of the implementation of digital national projects and the development of environmental responsibility of organizations. The role of greening the activities of enterprises in view of creating sustainable economic growth through the use of management solutions is shown. Special attention is paid to the construction of an environmental management concept aimed at minimizing financial and labor resources in the formation of the environmental image of the subject.
Features of calculating the cost of essential oil crops
Authors: Kostyukova E. I. , Neshchadimova T. A. , Khoruzhy V. I. , Dzhikiya K. A.
Published: September 2021

The article contains practical recommendations for calculating the cost of essential oil crops. A multi-level structure of the account 20 is proposed, which will allow obtaining information about the cost structure for each cultivated crop. The updated nomenclature of calculation items is presented, taking into account the specifics of growing essential oil crops, and the method of calculating the cost of finished products is considered.
Assessment of the impact of structural changes in sown areas on grain yields during the implementation of state programs
Authors: Demichev V. V. , Panin A. V. , Khoruzhy V. I. , Khudyakova E. V.
Published: September 2021

The article analyzes the dynamics and provides a forecast for 2021 of the yield of grain and leguminous crops in Russia. According to the results of the analysis for the period from 2006 to 2019, the average annual increase in yield by 0.6 center per ha was revealed for all categories of farms. The average grain yield in the forecast year will be in the range of 26.5 to 29.6 center per ha. The main focus of this article is on the assessment of the impact of structural shifts in sown areas on the yield of cereals and legumes. According to the results of the index method, it was found that due to changes in the regional structure of grain crops, the yield in Russia as a whole increased by an average of 5%. Based on the constructed regression model, it is concluded that the main factors affecting the grain yield are the productivity of the climate and the number of mineral fertilizers applied.
Comparative Study on Anaerobic Degradation Processes of Pressed Liquid Fraction of Organic Solid Waste
Authors: Rózsenberszki Tamás , Koók László , Bakonyi Péter , Nemestóthy Nándor , Bélafi-Bakó Katalin
Published: September 2021

Anaerobic degradation processes: anaerobic digestion (biogasification), biohydrogen fermentation (dark) and microbial fuel cells were applied to treat the organic fraction of a municipal solid waste. The processes were compared based on their ability of energy recovery and Chemical Oxygen Demand reduction.
Development of Compartment Models for Diagnostic Purposes
Authors: Tarcsay Bálint Levente , Bárkányi Ágnes , Chován Tibor , Németh Sándor
Published: September 2021

The importance of recognizing the presence of process faults and resolving these faults is continuously increasing parallel to the development of industrial processes. Fault detection methods which are both robust and sensitive help to recognize the presence of faults in time to avoid malfunctions, financial loss, environmental damage or loss of human life. In the literature, the use of various model-based fault detection methods has gained a considerable degree of popularity. Methods usually based on black-box models, data-based techniques or models using symbolic logic, e.g.\ expert systems, have become widespread. White-box models, on the other hand, have been applied less despite their considerable robustness because of multiple reasons. Firstly, their complexity and the relatively vast amount of technological and modelling knowledge needed to construct them for industrial systems. Secondly, their large computational demand which makes them less suitable for online fault detection. In this study, the aim was to resolve these problems by developing a method to simplify the complex Computational Fluid Dynamics models employed to describe the equipment used in the chemical industry into less complex model structures. These simpler structures are Compartment Models, a type of white-box model which breaks down a complex system into smaller units with idealized behaviour. In the case of a small number of compartments, the computational load of such models is not significant, therefore, they can be employed for the purposes of online fault detection while providing an accurate representation of the system. For the purpose of identifying the compartmental structure, fuzzy logic was employed to create a model which approximates the real behaviour of the system as accurately as possible. Our future objective is to explore the possibility of combining this model with various diagnostic methods (expert systems, Bayesian networks, parity relations, etc.) and derive robust tools for the purpose of fault detection.
Determinación de los parámetros óptimos en el procesamiento de la acara (Carica candicaens Gray) en almíbar
Authors: Huaylla Ramirez Kamiggia Jhonal , Ruiz Rodríguez Alfonso , Ore Areche Franklin
Published: September 2021

Perú   es   conocido   por   tener   una   gran diversidad  de  frutas  exóticas,  entre  ellas se  encuentra  la  Carica  candicaens  Gray. La presentación de almíbar de acara como una  alternativa  de  conservar  los  frutos e  incentivar  su  consumo.  El  objetivo  del estudio  fue  determinara  los  parámetros de   elaboración   del   almíbar   de   acara, determinar  la  aceptabilidad  y  realizar  el análisis microbiológico al almíbar de acara. Para la elaboración del se obtuvo el fruto de acara del distrito de Ticrapo, provincia de   Castrovirreyna   –   Huancavelica;   se realizaron    3    tratamientos,    cada    uno a   diferentes   temperaturas   y   tiempos. El  análisis  sensorial  se  realizó  con  15 panelistas semi entrenados, teniendo como resultado para el color 3,83 de aceptación, para el aroma 3,81 de aceptación, para el sabor 3,80 de aceptación y la consistencia 3,86 de aceptación. Del análisis sensorial puede  indicarse  que  existen  diferencias significativas para cada atributo evaluado entre los 3 tratamientos. El tratamiento 2 (T2) ha sido escaldado a 60 °C por 2 minutos. Para    las    características    fisicoquímicas del almíbar se determinó el pH y el °Brix, obteniendo  4,0  y  18  respectivamente,  lo cual indica que el almíbar está dentro de los rangos y se encuentra en la clasificación de  almíbar  ligero.  Se  realizó  el  análisis químico proximal al fruto y al almíbar, no habiendo diferencias en ambos resultados. Para     el     análisis     microbiológico     se determinó las Bacterias Aerobios Mesófilos <10 ufc/g, Coliformes totales <10 ufc/g y E. Coli NMP <3 NMP/g, este resultado indica que el producto se encuentra apto para el consumo humano.
Pengaruh Budaya Organisasi Dan Gaya Kepemimpinan Terhadap Kinerja Guru Swasta di Medan
Authors: Daulay Akman , Kalsum Eka Umi
Published: September 2021

This research explaints about organizational culture and leadership style on teacher performance at Yayasan Nasional Perguruan Brigjend Katamso Medan. The theory used in this research includes the theory of organizational culture, leadership style and performance. The population in this study were teacher at Yayasan Perguruan Nasional Brigjend Katamso Medan as many as 53 people. The data analysis model used is multiple regresion analysis. This research method uses descriptive quantitative supported by a survey and is explanatory. The results of the research by testing t-test hypothesis show the organizational culture has a positive and significant effect on teacher performance at Yayasan Perguruan Brigjend Katamso Medan. Leadership style has a positive and significant effect on teacher performance at Yayasan Perguruan Brigjend Katamso Medan. F test results show that the organizational culture and leadership style have positive and significant effect on teacher performance at Yayasan Perguruan Brigjend Katamso Medan. The value of the coefficient of determination of organizational culture and leadership style is able to explain the teacher performance variable of 82.6 % and the remaining 17.4 % is influenced by other variables not examined in this study.
Pengaruh Ukuran Perusahaan dan Umur Perusahaan Terhadap Tax Avoidance pada Sektor Pertambangan di BEI
Authors: Firmansyah Firmansyah
Published: September 2021

The purpose of this study was to determine the effect of company size on tax avoidance in mining companies on the IDX, to determine the effect of company age on tax avoidance in mining companies on the IDX, and to determine the effect of company size and company age on tax avoidance in mining companies on the IDX. The results of this study are the size of the company, and the age of the company affect tax avoidance either partially or simultaneously
Pengaruh Kewajiban Kepemilikan NPWP, Pemeriksaan Pajak Dan Penagihan Pajak Terhadap Penerimaan Pajak Pada Kantor Pelayanan Pajak Pratama Bangkinang
Authors: Masril Masril
Published: September 2021

The purpose of this study was to determine whether there is an effect of NPWP ownership obligations on tax receipts at the Bangkinang Pratama Tax Service Office, to find out whether there is an effect of tax audits on tax receipts at the Bangkinang Pratama Tax Service Office, to determine whether there is an effect of tax collection on tax receipts at the Pratama Tax Service Office. Bangkinan, and to find out whether the NPWP ownership obligation, tax audit and tax collection have a simultaneous effect on tax revenues at the Bangkinang Primary Service Office.
Analisis Faktor-Faktor Yang Mempengaruhi Kepuasan Konsumen Sakhi’s Coffee & Resto Di Kota Medan
Authors: Lubis Adelina , Tambunan Sari Bulan , Wijaya Muslim
Published: September 2021

This study aims to analyze the factors that affect the consumer satisfaction of Sakhi's Coffee Resto. The sample in this study were 100 people Sakhi's Coffee Resto consumers. The analytical technique used in this study is descriptive analysis and multiple linear regression test. The results of this study indicate that the product quality variable partially has a positive and significant effect on Sakhi' Coffee Resto consumer satisfaction, the service quality variable partially has a positive and significant effect on customer satisfaction. Sakhi' Coffee Resto consumer satisfaction, the price variable partially has a positive and significant effect on Sakhi' Coffee Resto consumer satisfaction. The Adjusted R Square value obtained is 0.363 this figure shows that it is 36.3%. Consumer satisfaction (the dependent variable) can be explained by the variables of product quality, service quality and price. The remaining 63.7% is influenced by other factors not described in this study.
Diri dan Pengetahuan Terhadap Kinerja Pegawai Pada Dinas Pekerjaan Umum Medan
Authors: Sitorus Yossi Suryandani , Nasution Amrin Mulia Utama , Parulian Tohap
Published: September 2021

The purpose of this study was to determine and analyze the effect of self-concept and knowledge on employee performance at the Medan Public Works Department. The research method used is associative research, where variables are measured with a Likert scale. Data collection methods by interview, questionnaire and observation. In this study the sample used was 80 respondents. Data management uses smartPLS3 with Structural Equation Modeling (SEM) analysis. The results showed that: (1) partially the self-concept variable influenced the performance of employees in the Medan Public Works Department by 5,825 (2) partially the knowledge variable affected the performance of the employees at the Medan Public Works Department by 7,738. R-Square value obtained is 0.642. To see the effect of independent variables on the dependent variable by calculating the coefficient of determination shows that 64.2% the remaining 35.8% is influenced by other factors not explained in this study.
Intervenções Terapêuticas na Paraparesia Espástica Tropical na Idade Adulta: uma revisão de literatura
Authors: Batista Amanda Rocha , Fragoso Neto Antônio Cabral , Netto Gustavo Henrique Pedrosa Braga , Cruz Juliana Marques de Paula , Serra Karina Luiza Rodrigues , Carneiro Laís Vanessa Pereira , Franco Leonardo Cortes de Aguiar , Costa Luana Cristina Rodrigues de Oliveira , Souza Maria Jakiciane Bezerra , Horta Wagner Gonçalves
Published: September 2021

Introdução. A paraparesia espástica, doença causada pelo HTLV-1, é considerada uma complicação grave e incapacitante para o paciente infectado, caracterizando-se como uma doença crônica e progressiva que gera sobretudo um processo inflamatório a nível medular e um enorme impacto no ambiente social da pessoa. Objetivos. Discutir as possibilidades terapêuticas atuais disponíveis para paraparesia espástica tropical em adultos. Método. Revisão sistemática de artigos publicados na plataforma PubMed entre 2015 e 2020. Resultados. Enose-Akahata et al, 2019, relatou que não houve eficácia clínica com o tratamento com Hu-Mik beta 1, apesar de não ter havido progressão da doença durante o tratamento. Sato et al, 2018, demonstrou que o uso de mogamulizumab, diminuiu o número de células infectadas pelo HTLV-1 e os níveis de marcadores inflamatórios, mas os efeitos clínicos precisam ser esclarecidos em pesquisas futuras. Nobre et al, 2018, determinou a diversidade genética do HTLV-1, observando uma taxa de variação baixa em comparação com demais vírus, como o da gripe e da varíola. Matsuo et al, 2018, nota que houve melhora sintomatológica após o tratamento com prosultiamina oral nos pacientes com bexiga hiperativa. Conclusão. Dessa forma, não há tratamento específico e totalmente eficaz, havendo a necessidade de associação de fármacos.
ORGANIZATION AND VERIFICATION OF MEASUREMENTS IN AUTOMOTIVE SERVICE CENTERS OF THE CITY OF VORONEZH
Authors:   Voronezh State University of Forestry and Technologies Named after G.F. Morozov, Yakovlev K.A. , Latynin A.V. ,   Voronezh State University of Forestry and Technologies named after G.F. Morozov, Yakovleva I.K. ,   Voronezh State University
Published: September 2021

Five fundamental principles of the 5S system (sorting, compliance, cleanliness, standardization and improvement) were considered as part of their application in a road transport enterprise.
RESEARCH OF OPERATING SYSTEMS AND THEIR DISTRIBUTION AMONG ORDINARY USERS AND SOFTWARE DEVELOPERS
Authors: Моисеенко Н.А. , Абубакиров А-М.М.
Published: September 2021

В данной статье будет проведено исследование операционных систем и выяснено каким операционным системамотдают предпочтение обычные пользователи иразличные разработчики ПО, для того чтобы в будущем использовать эти данные при разработке нового ПО.

In this article, we will conduct a study of operating systems and find out which operating systems are preferred by ordinary users and various software developers in order to use this data in the future when developing new software.
RESULTS OF HYDRAULIC FRACTURING AT ONE OF THE WELLS OF THE SADOVOYE FIELD
Authors: Чернова Е.В. , Омельченко М.В.
Published: September 2021

Суть гидроразрыва заключается в том, что в разрабатываемую скважину нагнетается жидкость разрыва, которая создаёт разницу в давлении, это провоцирует разрыв пласта. Чтобы трещина не сходилась, подаётся расклинивающий реагент - проппант, который удерживает нефтеносный пласт в раскрытом состоянии, повышая отдачу скважины.

The essence of hydraulic fracturing is that a fracturing fluid is injected into the developed well, which creates a difference in pressure, which provokes the formation rupture. In order for the crack not to converge, a proppant is supplied, which keeps the oil reservoir in the open state, increasing the return of the well.
INVOLVEMENT IN THE DEVELOPMENT OF HARD-TO-RECOVER RESERVES DUE TO THE COMMISSIONING OF WELLS OF COMPLEX ARCHITECTURE
Authors: Ковалев Д.В. , Муратов А. Т. , Кутуев М.У.
Published: September 2021

На сегодняшний день на месторождениях Западной Сибири разрабатывают множество месторождений с суммарным дебитом нефти более 90 тыс. тонн в сутки. Такие показатели нефтедобычи достигаются путем ввода в эксплуатацию объектов разработки с низкопродуктивными коллекторами [1,2]. Часть добычи нефти из таких объектов растет с каждым годом. Но недостаточно просто ввести их в разработку, необходимо также получить выгоду от их эксплуатации. С этой целью постоянно введутся мероприятия по внедрению новых, а также, усовершенствованию уже применящихся технологий при строительстве скважин [3,4].

Nowadays, many fields with a total oil production rate of more than 90 thousand tons per day are being developed in the fields of Western Siberia. Such indicators of oil production are achieved by putting into operation development facilities with low-productive reservoirs [1,2]. Part of the oil production from such facilities is growing every year. But it is not enough just to introduce them into development, it is also necessary to benefit from their operation. To this end, measures will be constantly introduced to introduce new technologies, as well as to improve the technologies already used in the construction of wells [3,4].
PRODUCTION OF SYNTHETIC WOLLASTONITE BASED ON PHOSPHORIC SLAG AND AMORPHOUS SILICA PRODUCED BY "SOLAR" SILICON
Authors: Вернер В.Ф. , Худякова Т.М. , Сарсенбаев Б.К. , Шакей А.М. , Сауганова Г.Р.
Published: September 2021

В статье приведены результаты исследований по получению синтетического волластонита на основе фосфорного шлаке и аморфного кремнезема от производства солнечного кремния. Установлено, что корректировка электротермофосфорного шлака аморфным кремнеземом от производства «солнечного» кремния облегчает процесс волластонитообразования, смещая его в область более низких температур 800-950оС и минимизирует количество примесных фаз при температурах 1000-1050оС устойчивого существования игольчатого волластонита.

The article presents the results of research on the production of synthetic wollastonite based on phosphoric slag and amorphous silica from the production of solar silicon. It is established that the correction of electrothermophosphoric slag with amorphous silica from the production of "solar" silicon facilitates the process of wollastonite formation, shifting it to the region of lower temperatures of 800-950oC and minimizes the number of impurity phases at temperatures of 1000-1050oC for the stable existence of needle wollastonite.
CALCULATION FOR THE SEISMIC EFFECTS OF THE MOSQUE BUILDING NAMED AFTER AYMANI KADYROVA IN ARGUN
Authors: Мажиев Х.Н. , Кадаев И.Х. , Духаев Х-М.С.
Published: September 2021

В статье рассматриваются расчеты на сейсмические воздействия уникального здания. С применением монолитного железобетонного перекрытия в рамном исполнении. А также из стальных конструкций в виде купола, расчеты выполняются программными комплексами «Лира» и «SCAD».

The article deals with calculations for seismic effects of unique building in the shape of a globe using a monolithic reinforced concrete floor in frame execution. And also from steel structures in the form of a dome, calculations are performed using software complexes "Lira","SCAD".
THE DEVELOPMENT OF SOCIETY IN THE CONTEXT OF THE TECHNOLOGICAL REVOLUTION
Authors: Усамов И.Р. , Магазиева З.А. , Гастамиров У.А.
Published: September 2021

Человечество испытывает на себе процесс технологической революции. Многие современные ученные и исследователи едины во мнении о том, что в настоящее время произошло значительное увеличение осадка технологической революции. Сегодня во все сферы деятельности внедряются современные информационные технологии. Если еще 10 лет назад нельзя было представить некоторые технологические процессы, то сегодня - это обычное дело. Процесс развития общества в условиях технологической революции охватывает процесс влиянии науки и техники на образование, сельское хозяйство, на окружающую среду, на коммуникацию, на здоровье и гигиену, на инфраструктуру, на правительство и его планирование. В статье рассматриваются отечественные и зарубежные источники по технологической революции и влиянию этого процесса на развитие общества. Сегодня человечество испытывает пик технологической революции.

Humanity is experiencing the process of technological revolution. Many modern scientists and researchers agree that there has been a significant increase in the precipitation of the technological revolution. Today, modern information technologies are being introduced into all spheres of activity. If 10 years ago it was impossible to imagine some technological processes, today it is a common thing. The process of development of society in the context of the technological revolution covers the impact of science and technology on education, agriculture, the environment, communication, health and hygiene, infrastructure, government and its planning. The article examines domestic and foreign sources on the technological revolution and the impact of this process on the development of society. Today, humanity is experiencing the peak of the technological revolution.
Comparison of inner macular thickness and superficial macular capillary vessel density acquired using classic and high-definition optical coherence tomography angiography scans
Authors: Hollo Gabor
Published: September 2021

Background: In ophthalmology, thickness and vessel density (VD) measurements for the 6 x 6 mm inner macular retinal area have received increasing attention in glaucomatous progression research. For this area, the Angiovue optical coherence tomography system introduced a 304 x 304 A/B scans function (classic Angio Retina scan) in 2014, and a 400 x 400 A/B scans function (high-definition [HD] Angio Retina scan) in 2017. These scan types cannot be used in combination for the software provided for progression analysis.Purpose: Since losing data for 3 years may negatively influence progression analysis, we investigated whether clinically significant differences exist between consecutive measurements acquired with these scan types on the same eyes.Methods: As a part of our noninterventional prospective glaucoma imaging study, primary-open-angle glaucoma patients (POAG group), and ocular hypertensive and healthy control participants (structurally undamaged group) were imagedusing both the classic and the HD Angio Retina scans, respectively, without changing the patients’ position. High-quality images were obtained on 12 POAG eyes of 12 consecutive POAG patients, and 10 healthy and ocular hypertensive eyes of 10 consecutive participants before the data collection had to be suspended due to the new coronavirus epidemic.Results: For Early Treatment Diabetic Retinopathy Study image area, the mean difference (classic minus HD value) was 0.02 ± 0.37 μm for inner retinal thickness (P = 0.869) and 0.33 ± 1.33 % (P = 0.452) for superficial capillary VD in the structurally normal group (between-methods difference: ≤ 0.8% of the respective normal value). In the POAG group, the corresponding figures were -0.07 ± 1.22 μm for inner retinal thickness (P = 0.854; between-methods difference: 0.6% of the normal value) and 1.12 ± 2.58 % for superficial capillary VD (P = 0.158; classic scan value minus HD scan value: 1.12 ± 2.58 %; 2.3% of the normal value).Conclusion: Our results suggest that combined use of thickness and VD values for structurally normal eyes and thickness values for POAG eyes derived from classic and HD scans, respectively, for progression analysis can be reasonable since the differences between the corresponding values are small. However, combining the corresponding VD parameters for POAG eyes is useful only when the follow-up time before the scan type change is long enough to counterbalance the effect of the change on the result.
Cloud-based genomics pipelines for ophthalmology: reviewed from research to clinical practice
Authors: Wong David C.S. , Olivera Maximiliano , Yu Jing , Szabo Anita , Moghul Ismail , Balaskas Konstantinos , Luben Robert , Khawaja Anthony P. , Pontikos Nikolas , Keane Pearse A.
Published: September 2021

Aim: To familiarize clinicians with clinical genomics, and to describe the potential of cloud computing for enabling the future routine use of genomics in eye hospital settings.Design: Review article exploring the potential for cloud-based genomic pipelines in eye hospitals.Methods: Narrative review of the literature relevant to clinical genomics and cloud computing, using PubMed and Google Scholar. A broad overview of these fields is provided, followed by key examples of their integration.Results: Cloud computing could benefit clinical genomics due to scalability of resources, potentially lower costs, and ease of data sharing between multiple institutions. Challenges include complex pricing of services, costs from mistakes or experimentation, data security, and privacy concerns.Conclusions and future perspectives: Clinical genomics is likely to become more routinely used in clinical practice. Currently this is delivered in highly specialist centers. In the future, cloud computing could enable delivery of clinical genomics services in non-specialist hospital settings, in a fast, cost-effective way, whilst enhancing collaboration between clinical and research teams.
AN OVERVIEW OF NEGATIVE MARKERS IN ENGLISH AND ALBANIAN
Authors: Bekteshi Arta
Published: September 2021

Negative sentences are the opposite of positive ones; they negate the action expressed in positive clauses by using negative markers and/or negative words. English and Albanian are two languages in which negation is structured and expressed in different ways, although the negative markers are more or less the same. However, even though they may seem similar and corresponding to each other in both languages, they are used in different structures and have different scope. This paper gives a description and comparison of negative markers in English and Albanian. Their use and structure is illustrated by various examples to support the description. Based on this overview, it can be concluded that both English and Albanian have negative particles functioning as negative markers, as well as negative words. However, these negative markers and negative words do not express negation in the same way in these two languages. The simplest difference is that English has only one negative marker of verbal negation – not; while Albanian has several negative markers: nuk/s’ to mark primary as well as secondary verbal negation, mos to mark verbal negation in the indicative, subjunctive, conditional and imperative mood; jo is used to mark both sentential and constituent negation; as- as a negative particle marks both sentential and constituent negation and can be accompanied by one of the verbal negative markers nuk /s’. Even though there is a correspondence of not and nuk /s’ to mark verbal negation, there is a misbalance of negative markers and their uses in both languages. A further difference, and a greater one is the use of n-words or negative polarity items (NPIs). English as a single negation language forms negation by using negative verbs with NPI, or by using n-words as absolute negators. For instance, (1) Ben didn’t see anybody vs. (2) Ben saw nobody. In sentence (1) there is a negative verb which cannot be followed or preceded by an n-word, therefore the NPI anybody is used, while in sentence (2) there is a positive verb which allows the use of an n-word such as nobody. On the other hand, in Albanian, n-words such as negative adverbs and negative pronouns are only used accompanied by the verbal marker nuk/s’, thus creating negative concord as in the example: Askush nuk tha asgjë. In this sentence there are three negative words – askush, nuk, asgjë- which contribute to one semantic meaning. As far as conjunctions are concerned, most of them correspond in both languages in both structure and meaning. Similarly, prefixes share similar properties in English and Albanian, they are attached to adjectives, verbs or nouns to express negation, opposition, reversative or removing ideas. English also has a negative suffix –less, while Albanian has no negative suffixes, which could be considered as a slight difference.
THE ROLE OF ANTONYMS IN BULGARIAN LANGUAGE TRAINING FOR DENTAL MEDICINE STUDENTS
Authors: Taneva Zlatka , Ayvazov Blagoy
Published: September 2021

The current topic on the role of the antonyms in the Bulgarian language training of dental medicine students is based on observations conducted in three groups in the specialty, first and second years respectively. When communicating with Bulgarian patients students have to use words of the opposite meaning, to specify a particular problem in determining the dental status of the patient. The choice of antonyms is mandatory for determining the degree of sensations, sensitivity of the tooth to hot or cold, sensations during the mastication of solid or soft food, treated and untreated caries, in necrotic or vital teeth, sharp or dull pain, in an intact or broken filling, in slow or fast chewing of food, and many others. We present the results of the survey, analyzing them and offering guidelines for future research in the field of antonymy and synonymy in the Bulgarian language. In the course of the study, we are reviewing the idea of opposition with the ancient philosophers, referring to Heraclitus, Pythagoras and Hegel, and more precisely the concept of the opposite, as an expression of duality. We also refer to the views of modern linguists who explore and classify antonyms. In the Bulgarian language learning process, we consider the partial opposition of the lexemes by showing examples from the practice of dental students. In part, we also consider incomplete (near) antonyms, the use of which is also found in students' work. We draw attention to distinguishing the role of antonyms in artistic literature and in scientific styles. We investigate the use of antonyms in the determination of temporal and spatial relations, indicating a common seme. Of course, not every concept or phenomenon has a precise antonym. We point out examples in which the use of one lexeme in an anonymous pair calls for the opposite. We note that the same opposing couple breaks their semantics into different linguistic situations. The present work is abundant with examples from the "Bulgarian language textbook for foreign students" 2018, which is used in the direct work of Bulgarian language teachers for training in the second year when introducing specialized texts on dental medicine A semantic analysis of the examples is made, indicating the degree of opposition in the respective antonymous pair. The aim of the study is to assist students in their practice with Bulgarian patients, especially when working with children, as the antonyms play a significant role in determining the dental status and the history of patients.
ART, MEANING AND CLASSIFICATION OF BULGARIAN FOLK DANCE
Authors: Malcheva Todorka
Published: September 2021

Playing Bulgarian folk dances- horoes, is a fascinating, emblematic and centuries’ years old tradition. The folk dance is an important part both from different holidays and from the everyday life of Bulgarians. This is one of the most significant and fascinating folklore activities, making Bulgaria famous all over the world. We can define Bulgarian national dance as an exceptionally beautiful art. This is a skill that makes people happy and energetic. Folk dances reveal the temper of our nation. At the same time, in the rhythm of the dance lives the collective spirit, which attributes to feeling joy, delight and rest when dancing with other people.That is why Bulgarian folk dance is not only a way to feel happy. It gathers, gives strength, teaches, expresses and above all- gathers the people of Bulgaria. It is also a way to be closer to nature. That is why Bulgarian folk dance is strength for the spirit. It is a magic for the soul- chases away tiredness and bad mood by generating positive energy and releasing the discomfort and stress. The following text presents classification of the Bulgarian folk dances- horoes according to different and various criteria. They are divided into groups according to: the performers, the type of dancing chain, metrorhythm, customs, folklore regions, tempo and others. The following resume confirms the variety and wealth of Bulgarian folk dance. The text also defines the dance as a magic that preserved our spirit and our nation throughout our history. It is not only a magic that is still alive, but a magic that is actively represented by different dancing formations nowadays. Bright costumes, thrilling music and energetic horoes – they always provoke emotions and loud applause among native and foreign public. The charming nature of Bulgarian dances is the reason why they are still alive and have been passed from one generation to the other. In this way, this centuries’ years old tradition will be preserved for the future generations and the Bulgarian shall never be forgotten.