bluuebunny/crossref_metadata_2025 huggingface dataset:
Há espaço para a Bioinformática no Ensino de Biologia? Lições de estudantes do Ensino Médio
Authors: Fernandes Tavares Cezar-de-Mello Paula , De Sousa Francisco Bruno , Dos Santos Ana Camilena , Domingos Coutinho Tarcisio José
Published: December 2023

O ensino de Genética e Biologia Molecular é, tradicionalmente, considerado desafiador tanto para estudantes quanto para docentes. A busca por novas estratégias didáticas que minimizem a abstração e privilegiem metodologias ativas têm se mostrado significativas para a aprendizagem. Com isso, buscamos avaliar o uso da Bioinformática como estratégia pedagógica no Ensino de Genética Molecular no âmbito do Ensino Médio. De acordo com a percepção discente, a Bioinformática se mostrou uma estratégia atraente (67%) e que viabilizou a compreensão do conteúdo abordado (50%). Aproximadamente, 83% do público pesquisado manifestou o interesse de realizar mais atividades semelhantes. Assim, refletimos sobre as potencialidades e desafios da implementação da Bioinformática enquanto recurso didático viável para o Ensino Médio.
America in A.P. Chekhov’s Creative Mind
Authors:   Perm State University, Abramova Victoriya S.
Published: December 2023

This paper focuses on American motifs and imagery, which form a single conceptosphere in the artistic world of Chekhov's prose. The absence of practical experience in knowing America, as well as the enrichment of the Russian world described in the texts with American references, are explored in the context of the writer's world modeling. The primary types of American representation are noted. A comparison of the settings, in which A. P. Chekhov's short stories reference America, exposes not only the consciousness of the perceiving character, but also helps to demonstrate the author's non-judgmental attitude toward ethnic stereotypes.
The Image of the Artist in Roger Eliot Fry’s Essay “Paul Cézanne”
Authors:   Perm State University, Novokreshchennykh Irina A. , Kosheleva Dar'ya A. ,   Perm State University
Published: December 2023

The article is devoted to analyzed the image of the artist Paul Cezanne in the essay of the same name by Roger Fry, which is a retelling of Vollard's earlier work on Cezanne. Recognizing the importance of Vollard for Cezanne as Vasari for Renaissance artists, Fry creates the emotional world of the artist. He describes some of his canvases in terms of form, not color.
The Image of the “New Woman” in the Novels by Ch. Brontë and N.G. Chernyshevsky
Authors:   Mariupol State University named after A.I. Kuindzhi, Nazarenko Nadezhda I.
Published: December 2023

The article presents a comparative analysis of the images of the main heroines of the novel «What is to be done?» N. G. Chernyshevsky and «Villette» by Ch. Brontё. The general theme and historical era provide grounds for comparing literary characters. Similar features in the development of female characters have been identified: origin, personality formation, motives of behavior, determination, lifestyle. It is also noted that these novels are characterized by certain genre characteristics of Bildungsroman. The analysis allows us to conclude that Vera Pavlovna and Lucy Snow represent the type of a “new woman” for European society of the mid-19th century.
Inadequacy of Children Formal Education on Henry James’s Fiction
Authors:   Institute of World Literature of the Russian Academy of Sciences, Obgolts Dmitry O.
Published: December 2023

The article analyzes the strategies of representation of formal education of children in Henry James’s fiction. For him, formal education fulfills other, non-educational, functions, and knowledge is narrowed down to an external material form. The pedagogical practices of such education are recognized as inadequate. When knowledge and its content are disclosed, however, it invariably has an applicable character and serves business and commercial activity.
The Postmodern Code of Barry Unsworth’s Novel “Morality Play”
Authors:   Kaluga State University named after K.E. Tsiolkovsky, Sadovnikova Yuliya M.
Published: December 2023

This article examines Barry Unsworth's novel "Moralite" (1995) through the prism of the concept of postmodern narrative, which was one of the first proposed by the American researcher Ihab Hassan. The absence, the destruction of the semantic structure – that's what, in his opinion, defines the new art at the end of the twentieth century. Postmodernism explodes from within traditional ideas about the integrity, harmony, completeness of aesthetic systems, their norms and criteria. Postmodern art is characterized by antiform, play, randomness and anarchy.
Simulation of a new process of mixing liquid metal in CCM mold with rotating cooling jacket with vertical ribs
Authors: Odinokov V. I. , Evstigneev A. I. , Dmitriev E. A. , Karpenko V. A.
Published: December 2023

The article proposes a new technology of filling the CCM mold with liquid metal and mixing it. The original patented device consists of a closed bottom nozzle and a rotating jacket. Experimental studies of liquid metal flow in a mold are long, complex and time-consuming, therefore, in the work was used mathematical modeling by numerical method. The objects of research are the hydrodynamic and thermal flows of liquid metal during the new process of steel casting into a CCM mold of rectangular cross-section, and the result is a spatial mathematical model that describes the flows and temperatures of liquid metal in the mold. To simulate the processes occurring during the metal flow in the mold, the authors used a specially crea­ted software package. The theoretical calculations are based on the fundamental equations of hydrodynamics, the equations of mathematical physics (equation of thermal conductivity taking into account mass transfer) and a proven numerical method. The area under study is divided into elements of finite dimensions, for each element a formulated system of equations is written in a difference form. The result is the velocity and temperature fields of the metal flow in the mold volume. According to the developed numerical schemes and algorithms, a calculation program was compiled. The paper considers an example of calculating the steel casting into a mold of rectangular cross-section and flow diagrams of liquid metal over various mold sections. Vector flows of liquid metal in various mold sections are clearly presented for different rotary speed of the rotating jacket. The authors identified the areas of intense turbulence and presented the results of the problem numerical solution in graphical form by diagrams of the velocity fields of liquid metal flows and their temperature over various mold sections.
The use of AES and EELS for complex analysis of two-dimensional coatings and their growth process
Authors: Plyusnin N. I.
Published: December 2023

Additional possibilities for complex analysis of two-dimensional coatings (thickness <1 nm or <10 ML) grown by physical vapor deposition (PVD) on a single-crystal silicon substrate under two deposition regimes are revealed: 1) low-temperature (at low beam temperature) and 2) high-temperature (at an elevated temperature of the beam), respectively. Coatings, including in the form of pure metal and a silicide mixture, and their interface with the substrate were analyzed by Auger electron spectroscopy (AES) and characteristic electron energy loss spectroscopy (EELS). To ensure both deposition regimes, a technology of the deposition from the ribboned source was developed. The traditional use of AES is limited to determining the composition of the elements, the energy electronic structure, and the thickness of the coating. And EELS — the types of phases (the density of valence electrons) and the stages of their formation. The simultaneous use of both methods and the choice of equal (and minimal) probing depths, ~ 2.5 nm (primary electron energy 300 eV), provided new possibilities for studying subnanometric two-dimensional coatings, in particular, — for comparison of the composition of coatings and their density. The chosen probing depth made it possible to characterize also interface between coating and substrate. At the same time, the same probing depth made it possible to use the thickness of the coating obtained from the AES data to analyze the data of the EELS. In addition, other possibilities are considered. This is the use of dependencies: a) the energy of the plasmon satellite of Auger peak, depending on the thickness of the coating, for analyzing changes in the electron density in the near-interface layer of silicon; B) attenuation of the Auger signal generated by marker atoms at the interface between the coating and the substrate to localize the places of adsorption of deposited atoms; and c) the intensity and energy of the loss peaks in the EELS in dependence on the primary-electron energy for profiling the composition of coatings over the depth. The use of two attenuation functions for two depths of probing provided a quantitative Auger analysis of binary coatings. All this made it possible to characterize more fully both the two-dimensional coatings themselves and the interface layer of the substrate, as well as the processes of their formation. And, in particular, this made it possible to identify for the first time the wetting nanophase layer of metal on a silicon substrate, to investigate the process of its formation and to show how its composition depends on the modes of vapor-phase physical deposition.
Las estrategias de desarrollo urbano sostenible integrado (EDUSI) en Asturias
Authors:   Universidade de Oviedo, Obeso Muñiz Ícaro
Published: December 2023

Objetivo de la Investigación: La progresiva europeización de las políticas urbanas ha encontrado en las Estrategias de Desarrollo Urbano Sostenible Integrado (EDUSI) durante el periodo de financiación 2014-2020 una herramienta transformadora en el modo de trabajo y la consolidación delenfoque integrado. Además, la clara delimitación del ámbito de actuación y la definición de líneas de actuación alineadas con los objetivos europeos han modificado la percepción de las políticas urbanas por parte de las entidades locales. Siete municipios asturianos se presentaron a las convocatorias llevadas a cabo en España. Finalmente, solo cuatro de ellos obtuvieron financiación para el desarrollo de sus estrategias: Avilés, Mieres, Oviedo y Siero. Así, el objetivo principal es el de conocer el impacto que han tenido las EDUSI en las ciudades asturianas y para ello se plantean una serie de preguntas que dirigen la investigación: ¿Se han llevado a cabo las medidas incluidas en los planes de acción de las diferentes estrategias presentadas por las ciudades asturianas? y ¿qué transformaciones se observan en las ciudades asturianas?Metodología: Se emplean métodos de investigación cualitativa, como el análisis documental, las entrevistas en profundidad, la representación cartográfica y la observación en campo.Resultados: Este artículo ofrece una evaluación cualitativa del grado de ejecución de las EDUSI en Asturias. Mientras Avilés, Mieres y Siero han completado la estrategia o la mayor parte de sus actuaciones, Oviedo corre el riesgo de perder parte de la cofinanciación europea. Entre los problemas identificados por los ayuntamientos se señalanla escasez de recursos humanos, la rigidez de la convocatoria, la carga burocrática y la complejidad en la gestión.Originalidad/Valor: Se ofrece una lectura crítica de las EDUSI más allá de los aspectos del diseño de la política europea, centrándose en el nivel de cumplimiento de las estrategias y en las transformaciones urbanas ejecutadas.
Barreiras para a sustentabilidade hídrica na Bacia do Rio Capibaribe: Um debate sobre desafios institucionais
Authors: Moura Micaella Raíssa Falcão de , Falcão Symone Maria Pancracio , Viana Mirella Alexandre , Rocha Layane Carmem Arruda da , Martins Nykollas Nuan Joseph Lima Neres
Published: December 2023

Desafios institucionais podem ter um impacto direto na sustentabilidade hídrica das bacias hidrográficas. Este estudo investiga os principais desafios institucionais da Bacia do Rio Capibaribe, localizada em Pernambuco – Brasil. Para atingir esse objetivo, este trabalho buscou entender se tais desafios podem ser configurados como barreiras para a sustentabilidade hídrica. A Bacia do Rio Capibaribe é o objeto; portanto, dada a disponibilidade de colaboração com a pesquisa, foram escolhidas duas instituições: Agência Pernambucana de Águas e Clima (APAC) e o Comitê da Bacia do Rio Capibaribe (COHB-Capibaribe). A metodologia consistiu na triangulação de métodos: análise de campo, análise documental e análise de conteúdo. A triangulação foi usada para formular uma matriz SWOT interinstitucional Apac-COBH/Capibaribe. Como resultado, este trabalho identificou três grandes desafios institucionais nos ambientes internos e externos do gerenciamento da bacia considerando as instituições analisadas Apac-COBH/Capibaribe: I) Conhecimento e Participação; II) Engajamento Operacional e III) Informação e Comunicação. Uma vez que as instituições analisadas articulam os interesses de diferentes setores para múltiplos usos da água, o estudo demonstrou que os desafios identificados podem se configurar como barreiras à sustentabilidade hídrica, gerando reflexos diretos na manutenção do equilíbrio dinâmico entre oferta e demanda hídrica na bacia.
The Differential Effects of Uphill Sprint and Side Jump Sprint Exercises and Various Anthropometric Characteristics on the Speed of Soccer Players
Authors: Kusuma I Dewa Made Aryananda Wijaya , Kusnanik Nining Widyah , Lumintuarso Ria , Rozy Fakhrur , Phanpheng Yanyong , Kusuma Donny Ardy
Published: December 2023

Study purpose. To increase the running speed of soccer players, anthropometric factors need to be considered when choosing a training model.
Materials and methods.  The experimental method with a 2 x 3 factorial design was used in this study. Purpose random sampling technique was used to select a sample of 60 participants from a population of 100 people. Then the sample was divided into six groups using a stratified random sampling technique (large UHS, n=10 participants; moderate UHS, n=10 participants; small UHS, n=10 participants; large SJS, n=10 participants; moderate SJS, n=10 participants; small SJS, n=10 participants). The 20-meter running speed test and anthropometric measurements were used as data collection instruments. Data analysis uses a two-way ANOVA and normality and homogeneity tests as prerequisites.
Results. The results of the study found that there were significant differences in the two training models with a Sig value of 0.002<0.05, there were significant differences in the three anthropometric groups with a Sig value of 0.000<0.05, andthere was an interaction between the training model and anthropometric characteristics in increasing the 20-meter running speed with a Sig value of 0.001<0.05.
Conclusions. This study concluded that the SJS training model was suitable for three levels of anthropometric ratios, while UHS was very suitable for small ones. Another conclusion was that the small anthropometric ratio had the greatest effect on the speed of the 20-meter sprint.
Does Sled Training with a Load of 10 Kilograms Have an Effect on the Speed of College Student Soccer Players?
Authors: Ikhsan Muhamad , Kusuma I Dewa Made Aryananda Wijaya , Syafii Imam , Prianto David Agus , Pramono Bayu Agung , Phanpheng Yanyong
Published: December 2023

Study purpose. Running speed is an ability soccer players need to build attack and defence. There needs to be more research in football that applies sleds using specific loads to improve the running ability of college student soccer players. This study aims to analyze the effect of sled training with a load of 10 kilograms on the running speed of college student soccer players.
Materials and methods. This study uses a quantitative approach with a quasi-experimental design research type, with the research design used being a one-group pretest-posttest design. The sample used in this research was 14 students taken from a population of 95 individuals using random sampling techniques. The study sample used had characteristics of age 18 ± 0.75 years, height 169.42 ± 5.84 cm, weight 58.5 ± 4.21 kg, and BMI 20.44 ± 2.00. Treatment was carried out for six weeks with a frequency of three times a week. The 20-meter sprint speed test was used as an instrument for collecting speed data. The data analysis technique uses a paired samples t-test at a significance level (α) 0.05. The prerequisite test used is the Shapiro-Wilk test.
Results. The research showed increased players’ running speed obtained from the pretest results of 4.48 ± 0.291 and the post-test results of 4.15 ± 0.266 from the 20-meter sprint test.
Conclusions. Based on the results of the paired sample t-test, it can be concluded that there is a significant increase in the running speed of college student soccer players using 10 kg sleds.
Examining the Effects of Reproductive and Productive Teaching Styles Interventions on Primary Schoolchildren. What Implications for Physical Education Teachers?
Authors: Monacis Domenico , Annoscia Sabrina , Limone Pierpaolo , Colella Dario
Published: December 2023

Background. In recent years, the study of the teacher-student relationship in the teaching-learning processes in physical education has had great emphasis. Previous studies have shown that the use of the Spectrum of Teaching Styles can enhance intrinsic motivation, enjoyment, adherence to physical activity and physical activity levels in children and adolescents.
Study purpose. The present study aims to assess if a physical education (PE) intervention based on the variations in teaching styles, with reference to productive ones, can also have positive effects on physical fitness.
Materials and methods. The sample involved 4 primary school classes (n = 124 children, mean age = 8–10 years) recruited from the SBAM (Health, Wellness, Food Education and Movement at School) Project in Apulia, Southern Italy. The classes were randomly assigned to the Experimental Group (EG) and the Control Group (CG). The EG followed a 5-month experimental intervention based on the variation of teaching styles, while the CG performed regular PE lessons. Physical fitness was assessed with Standing Long Jump (SLJ), 1kg Medicine Ball Throw (MBT), and 20 m sprint (20 m)tests, while two validated questionnaires were used to evaluate physical self-perception (PSP) and enjoyment. A 2x2 (intervention group x time) ANOVA was carried out to assess significant difference and interaction effect pre (t0) and post (t1) intervention protocol.
Results. Data analysis showed a significant improvement of physical fitness in both EG and CG, while PSP and enjoyment increased only in EG. Moreover, significant (p < .05) interaction effects were found for 20m sprint, PSP and Enjoyment with low effect size (η2 ~ .20).
Conclusions. The results of the present study highlight the effectiveness of a PE intervention based on the variation of teaching styles in improving physical fitness, self-perception, and enjoyment. Moreover, the use of productive teaching styles significantly impacts self-perception and enjoyment that are important mediating factors for guaranteeing better adherence to physical activity.
Relationship Between Stance Width Variation During One Repetition Maximum Barbell Hip Thrust Performance and Kicking Speed for Young Elite Silat Athletes
Authors: Mohd Nasir Muhammad Zulqarnain , Md Nadzalan Ali , Nor Azmi Abdul Muiz , Adnan Mohd Aizzat
Published: December 2023

Study purpose. This study aimed to determine the relationship between kicking speed performance and different stance widths during barbell hip thrust (BHT) at one repetition maximum (1RM) scores among young elite Silat athletes.
Materials and methods. 15 male and 15 female Silat athletes with at least one year of resistance training experience and a mean age of 21.3 ± 1.2 years participated in this study. The load indicator performance associated with kicking performance was measured using 1RM load during BHT at varying stance widths. The data was analyzed using Pearson correlation tests through the SPSS Version 25 application.
Results. A significant correlation was found between stance width, physical characteristics, and performance metrics with a low to moderate relationship. For physical features, weight (r=0.43, p<.05), height (r= 0.64, p<.05), and leg length (r= 0.44, p<.05) show positive relationship. Low to moderate significant relationships were found during WSW-RFK (r=0.39, p<.05) regarding 1RM and kicking performance. No significant correlations were found between NSW or NRW and the observed variables, except for a negative correlation between NRW and strength (r= -0.43, p < .05). There was a significant difference between males vs. females in RFK-NSW, RFK (p=0.006, p< .05), and LFK-NRW (p=0.001, p< .05) in kicking performance.
Conclusions. This study revealed that stance width in barbell hip thrusts moderately correlates with physical characteristics and performance in young elite Silat athletes, where wider stances align with physical characteristics and narrower stances align with lower kicking performance. It also highlighted the importance of personalized training due to observed gender differences in kicking speed.
Transforming Kempo Fitness: Enhancing Physiological Responses and Physical Performance in Adolescents via a Tabata-Based Method
Authors: Nurkholis  , Sifaq Aghus , Suyoko Andri , Nirwansyah Waristra Tyo , Pramono Bayu Agung , Arisanti Raden Roro Shinta
Published: December 2023

Study purpose. Examining the physiological and physical effects of Tabata training with Kempo sports movement techniques.
Materials and methods. The study participants were 16 adolescents divided into two distinct groups: the Tabata group and the non-Tabata group. The training was conducted for 6 weeks, 3 times per week, with each session lasting 2 hours. The training components for kicks and punches included Gyaku Geri, Jun Mawashi Geri, Jun Zuki, and Gyaku Mawashi Geri. Each teenager did physical exercise once a week for 2 hours. A normality test (Shapiro-Wilk) was used to assess the normality of the data. A Two-Way ANOVA with a significance level of less than 0.05 was conducted to examine the difference in means between the two groups. Furthermore, the researchers also tested the N-Gain Score to assess the effectiveness of the 6-week Tabata training program. All tests were conducted using SPSS version 23 and GraphPad Prisma version 10 for graph creation.
Results. The statistics indicate that a 6-week training with Tabata can effectively reduce resting heart rate and improve Standing Broad Jump (SBJ) performance by a value of sig. <0.05. In the pretest-posttest difference test within the group, the results show sig. <0.05. The results of the N-Gain Score test show that Kempo training using the Tabata method is effective in reducing resting heart rate by up to 88%, but is not effective in increasing power (SBJ) by a value of 10%.
Conclusions. The study revealed that incorporating the Tabata method into Kempo training, with necessary adjustments for 6 weeks, led to a notable reduction in resting heart rate. A decrease in resting heart rate is a dependable indicator of the advancement in physical fitness and general well-being in adolescents.
The Effects of LTAD-Based Programming on Fundamental Skills and Physical Abilities of Basketball Players Aged 11-12 Years
Authors: Hidayah Taufiq , Akhiruyanto Andry , Yudhistira Dewangga , Kurnianto Haris
Published: December 2023

Study purpose. The purpose of this research is to determine the effect of LTAD-based programming on the physical abilities and fundamental skills of basketball players aged 11-12 years.
Materials and methods. The research method used was an experimental one-group pretest-posttest design. The study participants included 50 basketball players, 25 males and 25 females, weighing ±50–70 kg and standing 159–172 cm tall.The instruments used consisted of a multistage fitness test, 30-meter sprint, Illinois run, layup, shooting under the ring, and free throw. Data was gathered by observation and testing. The data was analyzed descriptively using Wilcoxon and Mann-Whitney tests, which were aided by SPSS version 23.
Results. The results of the male and female groups’ pretest-posttest showed that the Asymp.sig (2-tailed) values for the aspects of endurance, speed, agility, layup, shooting under the ring, and free throw were 0.000<0.05. The results of the posttest comparison between males and females revealed that the Asymp.sig (2-tailed) value for the aspects of endurance, agility, speed, layup, and free throw was 0.264–0.938>0.05, only for shooting under the ring the Asymp.sig (2-tailed) value was 0.008 <0.05.
Conclusions. The male and female groups’ posttest results were better than the pretest results before LTAD-based programming. The majority of the posttest comparisons between males and females revealed no significant differences. This suggests that both the male and female groups improved after receiving LTAD-based programming.
Biomechanical Motion of the Tennis Forehand Stroke: Analyzing the Impact on the Ball Speed Using Biofor Analysis Software
Authors: Irawan Ricko , Azam Mahalul , Rahayu Setya , Setyawati Heny , Soedjatmiko  , Adi S  , Priyono Bambang , Nugroho Anan
Published: December 2023

Background. The inefficiency of the forehand stroke technique often stems from suboptimal execution of an athlete’s biomechanical movements. For a forehand stroke to be effective, each biomechanical component – the ankles, knees, hips, shoulders, and elbows – must function in an optimal manner. Disconnection of any of these elements can lead to ineffective technique. High speed, influenced by the racket speed at the point of impact, is a key indicator of a perfect forehand stroke. However, the challenge lies in the fact that an athlete’s movement and ball impact cannot be accurately observed with the naked eye, necessitating specialized tools for analysis.
Study purpose. The study aims to develop software that assists in predicting ball speed outcomes based on an athlete’s biomechanical movement during a forehand stroke execution.
Materials and methods. The research method employed R&D. Data collection techniques consisted of video recordings of athletes’ forehand strokes, which were later analyzed using software that examines movement angles of 10 national athletes.
Results. The results indicated the average angles of elbows = 106.23, shoulders = 153.62, hips = 165.33, knees = 167.63, ankles = 164.54; and ball speed = 199.41 cm/s.
Conclusions. The conclusion drawn is that to execute an effective forehand stroke with good ball speed, a moment of inertia must occur at the point of impact. The athletes should bend their elbow slightly, thereby reducing rotational resistance and increasing the speed of the racket head. The ankles, hips, and shoulders must move in synchronization within a continuous coordination chain, thereby allowing the athlete to fully leverage kinetic chain. The flexion movement of the elbow during the forward swing step is more effective than the extension movement where the elbow is slightly bent, resulting in a perfect shot.
Antioxidant and Anti-Inflammatory Properties of Bee Products Potentially Reduce Oxidative Stress and Inflammation After Physical Activity/Exercise: A Systematic Review
Authors: Kusuma Donny Ardy , Naharudin Mohamed Nashrudin Bin , Callixte Cyuzuzo , Aljunaid Muhammad , Firmansyah Awang , Mario Deby Tri , Ilham  , Komaini Anton , Ayubi Novadri
Published: December 2023

Study purpose. This research aims to analyze and highlight the potential of bee products in reducing oxidative stress and inflammation after physical activity/exercise.
Materials and methods. This research uses a systematic review method by searching various journal databases such as Scopus, Web of Science, PubMed and Embase. The inclusion criteria in this study were articles published in the last 5 years and articles discussing bee products, honey, oxidative stress, inflammation, physical activity, and exercise. The exclusion criteria in this study were articles published in disreputable journals. Titles, abstracts, and full texts of articles were screened then verified and stored in Mendeley software. A total of 7,124 articles from the Scopus, Web of Science, PubMed and Embase databases were identified. A total of 8 articles that met the inclusion criteria were selected and analyzed for this systematic review.
Results. Bee products that have anti-oxidant properties can reduce oxidative stress and the anti-inflammatory properties of bee products can reduce uncontrolled inflammation due to exercise.
Conclusions. Bee products contain flavonoids which have anti-oxidant properties which can reduce oxidative stress. In addition, the anti-inflammatory properties of bee products can reduce uncontrolled inflammation due to physical activity/exercise. In this case, honey works by inhibiting inflammation through NF-κB signals and reducing inflammation by suppressing the secretion of pro-inflammatory cytokines such as TNF-α and inflammatory markers such as CRP. Reducing inflammation can reduce the intensity of muscle pain. It is recommended that bee products be used in individuals to reduce oxidative stress and inflammation after physical activity/exercise.
The impact of economic complexity and industry specialization on the gross regional product of Russian regions
Authors: Kudrov Alexander
Published: December 2023

The economic complexity index defines the basis of the modern theory of economic complexity and reflects the level of knowledge embedded in the production structure of the economy. This study examines the direct relationship between the economic complexity index and gross regional product (GRP) while taking into account other factors of the GRP production function in its generalized representation. As a result, we can isolate the impact of the economic complexity index from other phenomena. The non-linear nature of the relationship between economic complexity and GRP is revealed, and the direct relationship is manifested only at sufficiently high values of economic complexity, exceeding a certain threshold, which is found endogenously using econometric methods. In addition, the paper studies the relationship between economic complexity and indices of sectoral specialization. We found that there is a direct relationship between economic complexity and the extractive industry index and no relationship with the level of development of manufacturing industry. We obtained a clarification of the generalized production function of GRP, in which the threshold effect of the influence of economic complexity manifested itself as a factor of nonlinear dependence describing the elasticity of labor: a high level of economic complexity provides greater labor productivity. Overall, the results of the study of the dependence of GRP on economic complexity lead to the conclusion that increasing economic complexity can be an effective way to stimulate economic growth and development, but only starting from a certain threshold level. This suggests that an economy must reach a minimum level of diversity and complexity in its industrial activities before it can experience the productivity gains necessary for substantial GRP growth.
MORPHOMETRIC AND FLUORESCENCE ANALYSIS OF NERVE GROWTH FACTOR-DIFFERENTIATED PC12 CELLS
Authors: ÜNAY Simge , ŞİRİNYILDIZ Ferhat
Published: December 2023

Objective

PC12 is a rat pheochromocytoma cell line. These

cells characteristically undergo differentiation when

cultured with nerve growth factor (NGF). Depending

on the dose of NGF, the length of neurite extensions

changes. Thanks to this differentiation property,

the cells are used in neuroscience and in modeling

pathophysiological diseases such as Alzheimer's,

Parkinson's, and Amyotrophic Lateral Sclerosis.

However, literature studies showing the effect of NGF

on neurite extensions formed in PC12 cells are very

limited. This study aimed to investigate the effect of

NGF on neurite extensions and cell viability depending

on dose and incubation time.

Materials and Methods

In this study, PC12 cells were incubated with 50 ng/ml

and 100 ng/ml NGF for 3, 6 and 7 days. The lengths

of neurite outgrowths and dead cell ratios were

calculated in incubated cells.

Results

The results showed that the length of neurite

extensions and dead cell ratio increased depending

on NGF doses and incubation time. When NGF

incubation times were compared, no difference was

found between 50 ng/ml NGF 6 days and 100 ng/ml

NGF 3 days groups.

Conclusion

When the dead cell ratios and sizes of neurite

extensions in the experimental groups are evaluated,

it is thought that 100 ng/ml NGF and 3 days incubation

time parameters are ideal for PC12 cell differentiation.
ÜNİVERSİTE ÖĞRENCİLERİNİN RUHSAL HASTALIKLARA YÖNELİK TUTUMLARI VE EMPATİ İLE İLİŞKİSİ
Authors: BACIK YAMAN Gözde , KUMBUL Hanım , KÖYÜSTÜ Büşra , HÜSEYNOV İbrahim , ÖZDAMAR ÜNAL Gülin
Published: December 2023

Amaç

Ruhsal hastalıklar dünya çapında önemli bir halk sağlığı

sorunudur. Bu araştırmada üniversite öğrencilerinin

ruhsal hastalıklara yönelik tutumlarını belirlemek

ve bunun empati ile ilişkisini incelemek amaçlanmaktadır.

Gereç Yöntem

Türkiye’de Eylül 2022 ile Nisan 2023 tarihleri arasında

çevirimiçi anket aracılığıyla kesitsel bir çalışma

gerçekleştirildi. 2022-2023 eğitim öğretim yılında üniversiteye

devam eden 666 üniversite öğrencisi Sosyodemografik

Veri Formu, Ruhsal Hastalıklara Yönelik

İnançlar Ölçeği ve Empati Ölçeğini içeren anketi

tamamladılar. Katılımcıların ruhsal hastalıklar ile ilgili

ders alıp almadıkları ve kendilerinde bir ruhsal hastalık

olduğunda bunu biriyle paylaşıp paylaşmayacakları

sorgulandı.

Bulgular

Cinsiyete göre kadınların Empati Ölçeği ortanca puanı

erkeklere göre istatiksel düzeyde anlamlı olarak

daha yüksek saptandı (sırasıyla p=0,085, p=
EPIGALLOCATECHIN GALLATE SENSITIZES PANCREATIC CANCER CELLS TO GEMCITABINE BY MODULATING MICRORNA EXPRESSION PROFILE
Authors: KAYGUSUZ Ali Haydar , SOGUTLU Fatma , BİRAY AVCI Çığır
Published: December 2023

Pancreatic cancer is a leading cause of cancer-related

deaths in developed countries, with a 5-year average

survival rate of less than 5%, making it a malignant

disease. Gemcitabine (GEM), an FDA-approved

pyrimidine antimetabolite, is widely used in pancreatic

cancer treatment. However, due to its targeting of

all dividing cells, severe side effects are frequently

observed in patients undergoing GEM treatment for

pancreatic cancer. Consequently, meta-analyses have

shown that the combination of GEM with other active

compounds significantly improves the 1-year survival

rate of pancreatic cancer patients. Epigallocatechin-

3-gallate (EGCG), an active compound found in

green tea (Camellia sinensis), has proven anticancer

activity in pancreatic cancer. Subsequent studies have

demonstrated that EGCG enhances the sensitivity of

pancreatic cancer cells to GEM. However, among

the studies conducted to date, the impact of the

combination of EGCG and GEM on the expression

of critical microRNAs, which act as key epigenetic

regulators in pancreatic cancer pathology, has not

been investigated. This study aims to determine the

cytotoxic and apoptotic effects of the combination of

GEM and EGCG on PANC1 cells and to examine its

effectiveness on the expression levels of microRNAs

involved in cancer progression.

Material and Method

Cytotoxicity of GEM and EGCG in PANC1 cells was

assessed using the WST-1 assay, and combination

effects were analyzed using isobologram analysis.

Apoptosis analysis was performed using the Annexin

V method. miRNA isolation was conducted with the

miRNeasy Kit, followed by cDNA synthesis using

the miScript II Reverse Transcription Kit. Changes

in the expression of miRNAs involved in cancer

cell proliferation, apoptosis, and metastasis were

examined using real-time qRT-PCR analysis.

Results

The IC50 values for GEM at 24, 48, and 72 hours were

determined as 72.85 μM, 26.55 μM, and 9.38 μM,

respectively. EGCG's IC50 values at 24, 48, and 72

hours were determined as 64.36 μM, 48.34 μM, and

19.73 μM, respectively. When combined at a 2:3 ratio

(GEM: EGCG) at 24 and 72 hours, a synergistic effect

was observed, while at 48 hours, a strong synergistic

drug interaction was observed. At a concentration of

only 26.55 μM, the group treated with GEM showed

a 4.2-fold increase in apoptosis compared to the

control group receiving fresh medium. In contrast,

the combination treatment (EGCG: 4.71 μM, GEM:

3.14 μM) resulted in a remarkable 12.04-fold increase

in apoptosis. After combination treatment, the

expression of tumor suppressor miRNAs, miR-137,

and miR-130a-3p, increased, while the expression of

oncogenic miRNAs, including miR-27a-3p, miR-425-

5p, miR-183-5p, miR-187-3p, miR-21-5p, miR-324-5p,

and miR-486-5p, decreased.

Conclusion

EGCG can sensitize pancreatic cancer to GEM

through epigenetic mechanisms, shedding light on

novel therapeutic approaches.
YAPAY ZEKÂ DESTEKLİ SOHBET ROBOTLARININ YAYGIN ORTODONTİK SORULARI CEVAPLAMA BAŞARISININ DEĞERLENDİRİLMESİ
Authors: TAŞKIN Sercan , GEÇGELEN CESUR Mine , UZUN Mustafa
Published: December 2023

Amaç

Bu çalışmada ortodontik tedavi gören hastaların ortodontistlerine

yaygın olarak sordukları soruların yapay

zekâ destekli sohbet robotları tarafından cevaplanma

başarısının değerlendirilmesi amaçlanmıştır.

Gereç ve Yöntem

Ortodontik tedavi gören hastaların yaygın olarak sordukları

15 soru internet veri tabanından araştırılarak

ChatGPT3.5, ChatGPT4, BING ve ZekAI uygulamalarına

15 Mayıs 2023’te sorulmuştur. Uygulamaların

verdikleri cevaplar iki ortodonti uzmanı, iki ortodonti

araştırma görevlisi ve iki diş hekimi tarafından 1 (en

yeterli)’den 5 (en yetersiz)’e kadar oluşturulan Likert

Skalası ölçeğine göre puanlanmıştır.

Bulgular

İstatistiksel değerlendirmeler sonucunda çalışmada

yer alan iki ortodonti uzmanı (MGC, MU) ve iki ortodonti

asistanı (AAA, ST) ChatGPT4 uygulamasına

BING uygulamasına göre istatistiksel olarak anlamlı

derecede düşük puan vermiştir (p
EFFECT OF DISTRACTION METHODS ON ACUTE PAIN IN ADULTS: RANDOMIZED CONTROLLED TRIAL
Authors: ÇAMLICA Tuğçe , ETİ ASLAN Fatma
Published: December 2023

Objective

This study aims to determine the pain experienced by

adult patients during the bloodletting procedure and

to reveal the effect of visual and auditory methods

on the level of pain compared to routine bloodletting

procedures.

Material and Method

The study was conducted as a randomized controlled

trial. The study was carried out in a blood collection

unit of a hospital on 15.01.2022. A total of ninety-nine

patients were randomized into three groups (visual,

auditory, and control groups). Visual Group patients

were asked to focus on the nature photograph on the

screen, and the Auditory Group patients were asked

to focus on the nature sounds they listened to. Data

were collected using the Personal Information Form

and the Visual Analog Scale (VAS). In the analysis

of the data, descriptive statistical methods, Kruskal-

Wallis, Pearson Chi-Square, and Monte Carlo Exact

Tests were used. The significance level was taken as

p
THE RELATION BETWEEN MODIFIED SYSTEMIC INFLAMMATION SCORE AND PROGNOSTIC MARKERS OF GASTROINTESTINAL STROMAL TUMORS
Authors: CANLIKARAKAYA Fırat , OCAKLI Serhat , CEYLAN Cengiz , GÖKTAŞ Abidin , GÜLER İlkay , TERZİOĞLU Serdar Gökay
Published: December 2023

Objective

Gastrointestinal stromal tumours are tumours of

mesenchymal origin that can be located along

the gastrointestinal tract. In this study, the role of

Modified systemic inflammation score in predicting

the prognosis of these tumours was investigated.

Material and Method

115 patients diagnosed with Gastrointestinal Stromal

Tumor (GIST) who underwent surgery at Ankara City

Hospital between June 1, 2019 and December 1,

2022 were examined. Tumor location, size, presence

of rupture-bleeding-necrosis, Ki-67 level, mitotic index

and preoperative albumin, lymphocyte and monocyte

levels were evaluated. mSIS score was grouped as

0, 1 and 2. The relationship between mSIS and Ki-

67 index and the presence of rupture, necrosis and

bleeding was investigated.

Results

Out of 115 patients, 68 (59 %) were male, 47 (41 %)

were female, with an average age of 62.5 (± 12.67)

years. Tumor locations: stomach (64.3 %), small

intestine (26 %), colon (5.2 %), esophagus (1.8 %),

pancreas (1.8 %), and ovary (0.9 %). Necrosis was

in 25 (30.7 %), hemorrhage in 67 (58.7 %), rupture

in 19 (16.8 %), and the mean Ki-67 level was 9.09 (±

10.64). 63 (54.8 %) patients had mSIS 0, 29 (25.2 %)

had mSIS 1, and 23 (20 %) had mSIS 2. Statistical

analysis found a significant correlation between mSIS

and necrosis, but not with other parameters.

Conclusion

The mSIS score is a valuable score showing

inflammation in the body and has been shown to be

associated with the prognosis of many malignancies.

In our study, the presence of necrosis in the tumour

was found to be associated with the mSIS score.

Although this result alone is not sufficient to predict

the prognosis, it is thought to be an issue that may

open the door to new studies.
ÜRETRAL DARLIK TEDAVİSİ SONRASI GELİŞEN NÜKS ORANLARI İLE İNFLAMATUAR KAN BELİRTEÇLERİ ARASINDAKİ İLİŞKİ
Authors: ERGÜN Osman
Published: December 2023

Amaç

Rutin kan tetkiklerinde çalışılan inflamatuar belirteç

ve bu belirteçlerin birbirleriyle oranları ile üretra darlığı

tedavisi sonrası gelişen nüks arasındaki ilişkiyi ortaya

koymak.

Gereç ve Yöntem

Çalışmaya internal üretrotomi operasyonu geçiren

142 hasta dahil edildi. Veriler retrospektif olarak tarandı.

Hastaların yaşları, eşlik eden komorbidite

durumları, kullandıkları tıbbi tedaviler, alışkanlıkları,

geçirdikleri cerrahi operasyonlar, işlem öncesi ve

sonrasında takiplerdeki üroflowmetre değerleri, darlık

lokalizasyonları ve uzunlukları, preoperatif ve post

operatif idrar ve kan tahlilleri kaydedildi.

Bulgular

İnternal üretrotomi operasyonu sonrası ilk bir yılda

nüks gelişme oranı %25,4 olarak tespit edildi. Ortalama

nüks süresi 8,9±1,9 aydı ve bu süre 1-12 ay

arasında değişmekteydi, ortanca nüks süresi ise 6 ay

olarak hesaplandı. Üretra darlığına neden olan etyolojik

faktörler incelendiğinde, iyatrojenik nedenlerin en

yaygın neden olduğu gözlemlendi. Nüks gelişen grup

ile gelişmeyen grup arasında lenfosit sayısı, platelet

sayısı, platelet-lenfosit oranı, red cell distribution width-

platelet oranı bakımından istatistiksel olarak anlamlı

farklar bulundu (p
Alienation and Violence in Beatriz Cabur’s Plays
Authors: Herrera Cárdenas María
Published: December 2023

In the last decades of the 21st century, the growing interest in legitimising contemporary Spanish female playwrights is evident in the context of contemporary feminist theories. This research explores Beatriz Cabur's plays, published and performed nationally and internationally, insofar as they respond to some of the current feminist demands regarding trauma. This study delves into the need for appropriate critical and analytical models for the study of theatrical experimentalism, which, in addition to its academic value, addresses current feminist demands. The development of this study is supported by clear thematic links that are established, from which it is possible to delve into the implicit and explicit feminisms of contemporary Spanish theatre, as well as the shaping, development, and legitimisation of contemporary feminine identities.
Re-articulation in Zora Neale Hurston’s Their Eyes Were Watching God
Authors: Sharma Divya
Published: December 2023

Zora Neale Hurston’s most acclaimed novel, Their Eyes Were Watching God (1937), juxtaposes the sensuous side of ecology with that of female sexuality and sensuousness, through the epiphany of the blossoming pear tree. The present research article explores this idea to establish Zora Neale Hurston as a womanist who anticipates ecofeminism and ecosexuality creating a female protagonist who finds a voice narrating her story.
Original Feminsims Or Mwenkanonkano In Uganda: Indigenous Voices In Jennifer Nansubuga Makumbi’s The First Woman
Authors: Tortosa Signes Lara
Published: December 2023

The purpose of this paper is to analyze the novel The First Woman by Jennifer Nansubuga Makumbi in the context of indigenous feminism(s). In the narrative, the protagonist discovers “the original state” of women according to the story she hears from the town witch, Nsuuta: before patriarchy, women were free like bodies of water, shapeless, inconstant, untamed. This original state has been suppressed by centuries of male dominance, but mwenkanonkano (the name the author gives to local feminism) is present in the life of many women who defy discrimination every day with their mere existence and the way they conduct their life. Nsuuta, by orally rendering the myths surrounding womanhood and passing them on to Kirabo, is writing (hi)story, legitimating it in their Ugandan context. Therefore, I argue that Makumbi conveys the need of an intersectional feminism which takes into consideration the life experiences of those women who are (and were) speaking up from their (un)comfortable homes. The author proves how significant these overlooked testimonies are since they are powerful examples of female survival in a society dominated by two intertwined forces: phallocracy and colonialism.
Subverting Patriarchal Narratives: Exploring Bhyrappa's Depiction of Sita Through Historiographic Metafiction
Authors: S Anjana , A R Savitha
Published: December 2023

The Ramayana, the ancient Hindu epic, has been retold and rewritten in various narrative forms by numerous writers from different countries. It has a global appeal that has inspired authors worldwide to create unique Ramayanas. Among these recreations, Bhyrappa's Uttarakaanda stands out with its multiple story views. This research paper, titled “Subverting Patriarchal Narratives: Exploring Bhyrappa’s Depiction of Sita Through Historiographic Metafiction,” delves into the author's methods of retelling the age-old narrative. The present study utilizes the conceptual frameworks of postmodernism, with a particular emphasis on historiographic metafiction. By delving into the deconstruction of grand narratives and questioning traditional elements that impede women's rights, the article aims to shed light on important thematic concerns. Specifically, the primary focus of this research lies in the analysis of the author's work titled 'Sitayana,' where the narrative spotlight is shifted from Rama to Sita. Through a meticulous examination of the author's adept incorporation of alternative perspectives, the paper explores how this approach resonates with both Indian literature and its readership. Moreover, the article critically engages with the power dynamics that influenced Rama's actions and shaped his understanding of dharma.
Modernite ve Akıl Karşıtlığının Kökenleri Üzerine
Authors: ÖZDEMİR İlker
Published: December 2023

Postmodern ve neoliberal anlayışlar moderniteye karşı açtıkları savaş sonucunda çoğulculuk ve görelilik iddiaları eşliğinde modernitenin uzun süre bastırmış olduğu mistik ve mitik algılama biçimlerinin geriye dönüşünü sağlamışlardır. 21. Yüzyılla birlikte neoliberal politikaların yarattığı hoşnutsuzluklar ve bu politikaları sürdüren küresel elitlere karşı artan tepkinin ise yeni sağ popülist hareketlerin yükselişlini beraberinde getirmiştir. Ancak, postmodern ve neoliberal hareketlerle yeni sağ popülist hareketler arasında, akıl ve modernite karşıtlığı bağlamında, bir karşıtlıktan çok bir devamlılık söz konusudur. Bu bağlamda neoliberal ve postmodern yaklaşımlar ve onlara tepki olarak ortaya çıkan yeni sağ popülist hareketler birbirinin devamı niteliğindedir. Postmodern ve neoliberal yaklaşımların eleştirel aklı tasfiye etme girişimi ve liderlik öğretileri yeni sağ popülist hareketler tarafından bir başka aşamaya taşınmıştır ve etno-dinsel hareketler 21. Yüzyıla damga vuran en önemli gelişmelerden biri olmuştur. Bu makale akıl karşıtlığının kökenlerini incelerken akıl karşıtlığının kuralsız/keyfi yönetimlere ve temel insan haklarının ihlaline yol açtığını göstermekte ve barış içinde birlikte yaşamak için akıldan vazgeçmek yerine aklı çoğaltmak gerektiğini öne sürmektedir.