bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure 2 from ADAM12 Produced by Tumor Cells Rather than Stromal Cells Accelerates Breast Tumor Progression
Authors: Fröhlich Camilla , Nehammer Camilla , Albrechtsen Reidar , Kronqvist Pauliina , Kveiborg Marie , Sehara-Fujisawa Atsuko , Mercurio Arthur M. , Wewer Ulla M.
Published: April 2023

PDF file - 238K, Stromal ADAM12 does not influence tumor growthA12null tumor cells examined by Western blot. Western blot analysis of ADAM12 expression in PyMT-A12hz, PyMT-A12null, and B16F10 cell lines. G, Mean (�SD) tumor volumes over time in wild-type (n=5), ADAM12+/- (n=11), or ADAM12-/- (n=6) mice on the C57/Bl6 genetic background injected s.c. with B16F10 melanoma cells.
Supplementary Figure 5 from Adaptive Basal Phosphorylation of eIF2α Is Responsible for Resistance to Cellular Stress–Induced Cell Death in Pten-Null Hepatocytes
Authors: Zeng Ni , Li Yang , He Lina , Xu Xiaoling , Galicia Vivian , Deng Chuxia , Stiles Bangyan L.
Published: April 2023

PDF file - 2.2MB
Supplementary Figure 3 from Adaptive Basal Phosphorylation of eIF2α Is Responsible for Resistance to Cellular Stress–Induced Cell Death in Pten-Null Hepatocytes
Authors: Zeng Ni , Li Yang , He Lina , Xu Xiaoling , Galicia Vivian , Deng Chuxia , Stiles Bangyan L.
Published: April 2023

PDF file - 249K
Supplementary Figure 2 from Adaptive Basal Phosphorylation of eIF2α Is Responsible for Resistance to Cellular Stress–Induced Cell Death in Pten-Null Hepatocytes
Authors: Zeng Ni , Li Yang , He Lina , Xu Xiaoling , Galicia Vivian , Deng Chuxia , Stiles Bangyan L.
Published: April 2023

PDF file - 245K
Supplementary Figure 1 from Adaptive Basal Phosphorylation of eIF2α Is Responsible for Resistance to Cellular Stress–Induced Cell Death in Pten-Null Hepatocytes
Authors: Zeng Ni , Li Yang , He Lina , Xu Xiaoling , Galicia Vivian , Deng Chuxia , Stiles Bangyan L.
Published: April 2023

PDF file - 9.9MB
Supplementary Table 1, Figures 1-4 from Notch1 Inhibition Alters the CD44hi/CD24lo Population and Reduces the Formation of Brain Metastases from Breast Cancer
Authors: McGowan Patricia M. , Simedrea Carmen , Ribot Emeline J. , Foster Paula J. , Palmieri Diane , Steeg Patricia S. , Allan Alison L. , Chambers Ann F.
Published: April 2023

Supplementary Table 1, Figures 1-4 from Notch1 Inhibition Alters the CD44hi/CD24lo Population and Reduces the Formation of Brain Metastases from Breast Cancer
Supplementary Figure 2 from Methyl-Binding Domain Protein 2–Dependent Proliferation and Survival of Breast Cancer Cells
Authors: Mian Omar Y. , Wang Shou Zhen , Zhu Sheng Zu , Gnanapragasam Merlin N. , Graham Laura , Bear Harry D. , Ginder Gordon D.
Published: April 2023

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Supplementary Data from Oncogenic Activating Mutations Are Associated with Local Copy Gain
Authors: Modrek Barmak , Ge Lin , Pandita Ajay , Lin Eva , Mohan Sankar , Yue Peng , Guerrero Steve , Lin William M. , Pham Thinh , Modrusan Zora , Seshagiri Somasekar , Stern Howard M. , Waring Paul , Garraway Levi A. , Chant John , Stokoe David , Cavet Guy
Published: April 2023

Supplementary Data from Oncogenic Activating Mutations Are Associated with Local Copy Gain
Supplementary Figures 1-7 from KIAA0101 Interacts with BRCA1 and Regulates Centrosome Number
Authors: Kais Zeina , Barsky Sanford H. , Mathsyaraja Haritha , Zha Alicia , Ransburgh Derek J.R. , He Gang , Pilarski Robert T. , Shapiro Charles L. , Huang Kun , Parvin Jeffrey D.
Published: April 2023

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Supplementary Data from miRNA-223 Promotes Gastric Cancer Invasion and Metastasis by Targeting Tumor Suppressor EPB41L3
Authors: Li Xiaohua , Zhang Ying , Zhang Hongwei , Liu Xiaonan , Gong Taiqian , Li Mengbin , Sun Li , Ji Gang , Shi Yongquan , Han Zheyi , Han Shuang , Nie Yongzhang , Chen Xiong , Zhao Qinchuan , Ding Jie , Wu Kaichun , Daiming Fan
Published: April 2023

Supplementary Figure S1; Supplementary Table S1.
Supplementary Figure 2 from CXCR4 Promotes Oral Squamous Cell Carcinoma Migration and Invasion through Inducing Expression of MMP-9 and MMP-13 via the ERK Signaling Pathway
Authors: Yu Tao , Wu Yingying , Helman Joseph I. , Wen Yuming , Wang Changmei , Li Longjiang
Published: April 2023

PDF - 119K
Supplementary Figure 1 from CXCR4 Promotes Oral Squamous Cell Carcinoma Migration and Invasion through Inducing Expression of MMP-9 and MMP-13 via the ERK Signaling Pathway
Authors: Yu Tao , Wu Yingying , Helman Joseph I. , Wen Yuming , Wang Changmei , Li Longjiang
Published: April 2023

PDF - 174K
Supplementary Table 1 from Suppression of IRF4 by IRF1, 3, and 7 in Noxa Expression Is a Necessary Event for IFN-γ–Mediated Tumor Elimination
Authors: Piya Sujan , Moon Ae Ran , Song Peter I. , Hiscott John , Lin Rongtuan , Seol Dai-Wu , Kim Tae-Hyoung
Published: April 2023

PDF file - 900K
Supplementary Tables S1-S2 from Mutual Regulation of Hypoxia-Inducible Factor and Mammalian Target of Rapamycin as a Function of Oxygen Availability
Authors: Knaup Karl X. , Jozefowski Katrin , Schmidt Regina , Bernhardt Wanja M. , Weidemann Alexander , Juergensen Jan Steffen , Warnecke Christina , Eckardt Kai-Uwe , Wiesener Michael S.
Published: April 2023

Supplementary Tables S1-S2 from Mutual Regulation of Hypoxia-Inducible Factor and Mammalian Target of Rapamycin as a Function of Oxygen Availability
Supplementary Figure 3 from Suppression of IRF4 by IRF1, 3, and 7 in Noxa Expression Is a Necessary Event for IFN-γ–Mediated Tumor Elimination
Authors: Piya Sujan , Moon Ae Ran , Song Peter I. , Hiscott John , Lin Rongtuan , Seol Dai-Wu , Kim Tae-Hyoung
Published: April 2023

PDF file - 822K
Supplementary Figure S1 from Boswellic Acid Blocks Signal Transducers and Activators of Transcription 3 Signaling, Proliferation, and Survival of Multiple Myeloma via the Protein Tyrosine Phosphatase SHP-1
Authors: Kunnumakkara Ajaikumar B. , Nair Asha S. , Sung Bokyung , Pandey Manoj K. , Aggarwal Bharat B.
Published: April 2023

Supplementary Figure S1 from Boswellic Acid Blocks Signal Transducers and Activators of Transcription 3 Signaling, Proliferation, and Survival of Multiple Myeloma via the Protein Tyrosine Phosphatase SHP-1
Supplementary Figure 2 from Suppression of IRF4 by IRF1, 3, and 7 in Noxa Expression Is a Necessary Event for IFN-γ–Mediated Tumor Elimination
Authors: Piya Sujan , Moon Ae Ran , Song Peter I. , Hiscott John , Lin Rongtuan , Seol Dai-Wu , Kim Tae-Hyoung
Published: April 2023

PDF file - 2.04MB
Supplementary Figure 1 from Suppression of IRF4 by IRF1, 3, and 7 in Noxa Expression Is a Necessary Event for IFN-γ–Mediated Tumor Elimination
Authors: Piya Sujan , Moon Ae Ran , Song Peter I. , Hiscott John , Lin Rongtuan , Seol Dai-Wu , Kim Tae-Hyoung
Published: April 2023

PDF file - 931K
Supplementary Data from Regulation of Expression of Stromal-Derived Factor-1 Receptors: CXCR4 and CXCR7 in Human Rhabdomyosarcomas
Authors: Tarnowski Maciej , Grymula Katarzyna , Reca Ryan , Jankowski Kacper , Maksym Radoslaw , Tarnowska Joanna , Przybylski Grzegorz , Barr Frederic G. , Kucia Magdalena , Ratajczak Mariusz Z.
Published: April 2023

Supplementary Data from Regulation of Expression of Stromal-Derived Factor-1 Receptors: CXCR4 and CXCR7 in Human Rhabdomyosarcomas
Supplementary Figure 1, Tables 1-2 from Differential Hypoxic Regulation of Hypoxia-Inducible Factors 1α and 2α
Authors: Lin Qun , Cong Xiangyu , Yun Zhong
Published: April 2023

Supplementary Figure 1, Tables 1-2 from Differential Hypoxic Regulation of Hypoxia-Inducible Factors 1α and 2α
Supplementary Data from Inactivation of the MAL Gene in Breast Cancer Is a Common Event That Predicts Benefit from Adjuvant Chemotherapy
Authors: Horne Hisani N. , Lee Paula S. , Murphy Susan K. , Alonso Miguel A. , Olson John A. , Marks Jeffrey R.
Published: April 2023

Supplementary Data from Inactivation of the MAL Gene in Breast Cancer Is a Common Event That Predicts Benefit from Adjuvant Chemotherapy
Supplementary Figure Legends from Upregulation of ABCG2 by Romidepsin via the Aryl Hydrocarbon Receptor Pathway
Authors: To Kenneth K.W. , Robey Robert , Zhan Zhirong , Bangiolo Lois , Bates Susan E.
Published: April 2023

Supplementary Figure Legends 1-3
Supplementary Figure 3 from Upregulation of ABCG2 by Romidepsin via the Aryl Hydrocarbon Receptor Pathway
Authors: To Kenneth K.W. , Robey Robert , Zhan Zhirong , Bangiolo Lois , Bates Susan E.
Published: April 2023

S3. Immunoprecipitation assay showing that romidepsin led to a dissociation of AhR from Hsp90 in the responsive cell lines.
Supplementary Figure Legends 1-2, Table 1 from Blockade of Fatty Acid Synthase Induces Ubiquitination and Degradation of Phosphoinositide-3-Kinase Signaling Proteins in Ovarian Cancer
Authors: Tomek Katharina , Wagner Renate , Varga Franz , Singer Christian F. , Karlic Heidrun , Grunt Thomas W.
Published: April 2023

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Supplementary Figure 2 from Blockade of Fatty Acid Synthase Induces Ubiquitination and Degradation of Phosphoinositide-3-Kinase Signaling Proteins in Ovarian Cancer
Authors: Tomek Katharina , Wagner Renate , Varga Franz , Singer Christian F. , Karlic Heidrun , Grunt Thomas W.
Published: April 2023

PDF file - 18K
Supplementary Figure 1 from Blockade of Fatty Acid Synthase Induces Ubiquitination and Degradation of Phosphoinositide-3-Kinase Signaling Proteins in Ovarian Cancer
Authors: Tomek Katharina , Wagner Renate , Varga Franz , Singer Christian F. , Karlic Heidrun , Grunt Thomas W.
Published: April 2023

PDF file - 72K
Supplementary Tables S1-S3 from Oncogenic Ras and Transforming Growth Factor-β Synergistically Regulate AU-Rich Element–Containing mRNAs during Epithelial to Mesenchymal Transition
Authors: Kanies Cindy L. , Smith J. Joshua , Kis Christian , Schmidt Carl , Levy Shawn , Khabar Khalid S.A. , Morrow Jason , Deane Natasha , Dixon Dan A. , Beauchamp R. Daniel
Published: April 2023

Supplementary Tables S1-S3 from Oncogenic Ras and Transforming Growth Factor-β Synergistically Regulate AU-Rich Element–Containing mRNAs during Epithelial to Mesenchymal Transition
Supplementary Data from BAD, a Proapoptotic Member of the BCL2 Family, Is a Potential Therapeutic Target in Hepatocellular Carcinoma
Authors: Galmiche Antoine , Ezzoukhry Zakaria , François Catherine , Louandre Christophe , Sabbagh Charles , Nguyen-Khac Eric , Descamps Véronique , Trouillet Nathalie , Godin Corinne , Regimbeau Jean-Marc , Joly Jean-Paul , Barbare Jean-Claude , Duverlie Gilles , Mazière Jean-Claude , Chatelain Denis
Published: April 2023

Supplementary Figures S1-S6; Supplementary Materials and Methods; Supplementary Table S1.
Supplementary Figures S1-S4 from Epigenetic Upregulation of Urokinase Plasminogen Activator Promotes the Tropism of Mesenchymal Stem Cells for Tumor Cells
Authors: Pulukuri Sai Murali Krishna , Gorantla Bharathi , Dasari Venkata Ramesh , Gondi Christopher S. , Rao Jasti S.
Published: April 2023

Supplementary Figures S1-S4.
Supplementary Data from Zebrafish Hagoromo Mutants Up-Regulate fgf8 Postembryonically and Develop Neuroblastoma
Authors: Amsterdam Adam , Lai Kevin , Komisarczuk Anna Z. , Becker Thomas S. , Bronson Roderick T. , Hopkins Nancy , Lees Jacqueline A.
Published: April 2023

Supplementary Data from Zebrafish Hagoromo Mutants Up-Regulate fgf8 Postembryonically and Develop Neuroblastoma
Supplementary Data from FOXO Transcription Factors Enforce Cell Cycle Checkpoints and Promote Survival of Hematopoietic Cells after DNA Damage
Authors: Lei Hong , Quelle Frederick W.
Published: April 2023

Supplementary Data from FOXO Transcription Factors Enforce Cell Cycle Checkpoints and Promote Survival of Hematopoietic Cells after DNA Damage
Supplementary Data from Expression of Epidermal Growth Factor Receptor or ErbB3 Facilitates Geldanamycin-Induced Down-Regulation of ErbB2
Authors: Pedersen Nina Marie , Breen Kamilla , Rødland Marianne Skeie , Haslekås Camilla , Stang Espen , Madshus Inger Helene
Published: April 2023

Supplementary Data from Expression of Epidermal Growth Factor Receptor or ErbB3 Facilitates Geldanamycin-Induced Down-Regulation of ErbB2
Supplementary Table S1 from Deletion at Fragile Sites Is a Common and Early Event in Barrett's Esophagus
Authors: Lai Lisa A. , Kostadinov Rumen , Barrett Michael T. , Peiffer Daniel A. , Pokholok Dimitry , Odze Robert , Sanchez Carissa A. , Maley Carlo C. , Reid Brian J. , Gunderson Kevin L. , Rabinovitch Peter S.
Published: April 2023

Supplementary Table S1.
Supplementary Data from The MicroRNA Profile of Prostate Carcinoma Obtained by Deep Sequencing
Authors: Szczyrba Jaroslaw , Löprich Elke , Wach Sven , Jung Volker , Unteregger Gerhard , Barth Stephanie , Grobholz Rainer , Wieland Wolf , Stöhr Robert , Hartmann Arndt , Wullich Bernd , Grässer Friedrich
Published: April 2023

Supplementary Data from The MicroRNA Profile of Prostate Carcinoma Obtained by Deep Sequencing
Supplementary Figure S1 from Antifolate Activity of Pyrimethamine Enhances Temozolomide-Induced Cytotoxicity in Melanoma Cells
Authors: Chen Ming , Osman Iman , Orlow Seth J.
Published: April 2023

Supplementary Figure S1 from Antifolate Activity of Pyrimethamine Enhances Temozolomide-Induced Cytotoxicity in Melanoma Cells
Supplementary Data from Antifolate Activity of Pyrimethamine Enhances Temozolomide-Induced Cytotoxicity in Melanoma Cells
Authors: Chen Ming , Osman Iman , Orlow Seth J.
Published: April 2023

Supplementary Data from Antifolate Activity of Pyrimethamine Enhances Temozolomide-Induced Cytotoxicity in Melanoma Cells
Supplementary Figures S1-S2 from Aldehyde Dehydrogenase 1 Is a Tumor Stem Cell-Associated Marker in Lung Cancer
Authors: Jiang Feng , Qiu Qi , Khanna Abha , Todd Nevins W. , Deepak Janaki , Xing Lingxiao , Wang Huijun , Liu Zhenqiu , Su Yun , Stass Sanford A. , Katz Ruth L.
Published: April 2023

Supplementary Figures S1-S2 from Aldehyde Dehydrogenase 1 Is a Tumor Stem Cell-Associated Marker in Lung Cancer
Supplementary Tables 1-4, Figures 1-4 from Circulating Tumor Cells from Patients with Advanced Prostate and Breast Cancer Display Both Epithelial and Mesenchymal Markers
Authors: Armstrong Andrew J. , Marengo Matthew S. , Oltean Sebastian , Kemeny Gabor , Bitting Rhonda L. , Turnbull James D. , Herold Christina I. , Marcom Paul K. , George Daniel J. , Garcia-Blanco Mariano A.
Published: April 2023

Supplementary Tables 1-4, Figures 1-4 from Circulating Tumor Cells from Patients with Advanced Prostate and Breast Cancer Display Both Epithelial and Mesenchymal Markers
Supplementary Figures 1-5 from Cancer-Associated Fibroblasts Derived from EGFR-TKI–Resistant Tumors Reverse EGFR Pathway Inhibition by EGFR-TKIs
Authors: Mink Sheldon R. , Vashistha Surabhi , Zhang Wenxuan , Hodge Amanda , Agus David B. , Jain Anjali
Published: April 2023

Supplementary Figures 1-5 from Cancer-Associated Fibroblasts Derived from EGFR-TKI–Resistant Tumors Reverse EGFR Pathway Inhibition by EGFR-TKIs
Supplementary Data from DOC45, a Novel DNA Damage–Regulated Nucleocytoplasmic ATPase That Is Overexpressed in Multiple Human Malignancies
Authors: Sun Hong , Luo Xiuquan , Montalbano JoAnne , Jin Weixin , Shi Jingxue , Sheikh M. Saeed , Huang Ying
Published: April 2023

Supplementary Data from DOC45, a Novel DNA Damage–Regulated Nucleocytoplasmic ATPase That Is Overexpressed in Multiple Human Malignancies
Supplementary Figures S1-S2 from The RNA-Binding Protein HuR Promotes Glioma Growth and Treatment Resistance
Authors: Filippova Natalia , Yang Xiuhua , Wang Yimin , Gillespie G. Yancey , Langford Cathy , King Peter H. , Wheeler Crystal , Nabors L. Burt
Published: April 2023

Supplementary Figures S1-S2 from The RNA-Binding Protein HuR Promotes Glioma Growth and Treatment Resistance
Supplementary Data from Bmi1 Functions as an Oncogene Independent of Ink4A/Arf Repression in Hepatic Carcinogenesis
Authors: Xu Chuan-Rui , Lee Susie , Ho Coral , Bommi Prashant , Huang Shi-Ang , Cheung Siu Tim , Dimri Goberdhan P. , Chen Xin
Published: April 2023

Supplementary Data from Bmi1 Functions as an Oncogene Independent of Ink4A/Arf Repression in Hepatic Carcinogenesis
Supplementary Data from β-Arrestin/Ral Signaling Regulates Lysophosphatidic Acid–Mediated Migration and Invasion of Human Breast Tumor Cells
Authors: Li Timothy T. , Alemayehu Mistre , Aziziyeh Adel I. , Pape Cynthia , Pampillo Macarena , Postovit Lynne-Marie , Mills Gordon B. , Babwah Andy V. , Bhattacharya Moshmi
Published: April 2023

Supplementary Data from β-Arrestin/Ral Signaling Regulates Lysophosphatidic Acid–Mediated Migration and Invasion of Human Breast Tumor Cells
Supplementary Figure S1 from Up-Regulation of Connective Tissue Growth Factor in Endothelial Cells by the Microtubule-Destabilizing Agent Combretastatin A-4
Authors: Samarin Jana , Rehm Margot , Krueger Bettina , Waschke Jens , Goppelt-Struebe Margarete
Published: April 2023

Supplementary Figure S1 from Up-Regulation of Connective Tissue Growth Factor in Endothelial Cells by the Microtubule-Destabilizing Agent Combretastatin A-4
Supplementary Methods, Tables 1-2, Figures 1-4 from Interplay Between pVHL and mTORC1 Pathways in Clear-Cell Renal Cell Carcinoma
Authors: Kucejova Blanka , Peña-Llopis Samuel , Yamasaki Toshinari , Sivanand Sharanya , Tran Tram Anh T. , Alexander Shane , Wolff Nicholas C. , Lotan Yair , Xie Xian-Jin , Kabbani Wareef , Kapur Payal , Brugarolas James
Published: April 2023

PDF file - 201K
Supplementary Figure 5 from Lrig1 Is an Estrogen-Regulated Growth Suppressor and Correlates with Longer Relapse-Free Survival in ERα-Positive Breast Cancer
Authors: Krig Sheryl R. , Frietze Seth , Simion Catalina , Miller Jamie K. , Fry Will H.D. , Rafidi Hanine , Kotelawala Lakmal , Qi Lihong , Griffith Obi L. , Gray Joe W. , Carraway Kermit L. , Sweeney Colleen
Published: April 2023

PDF file - 871K
Supplementary Data from Inhibition of G1 to S Phase Progression by a Novel Zinc Finger Protein P58TFL at P-bodies
Authors: Minagawa Kentaro , Katayama Yoshio , Nishikawa Shinichiro , Yamamoto Katsuya , Sada Akiko , Okamura Atsuo , Shimoyama Manabu , Matsui Toshimitsu
Published: April 2023

Supplementary Data from Inhibition of G1 to S Phase Progression by a Novel Zinc Finger Protein P58TFL at P-bodies
Supplementary Figure 4 from Lrig1 Is an Estrogen-Regulated Growth Suppressor and Correlates with Longer Relapse-Free Survival in ERα-Positive Breast Cancer
Authors: Krig Sheryl R. , Frietze Seth , Simion Catalina , Miller Jamie K. , Fry Will H.D. , Rafidi Hanine , Kotelawala Lakmal , Qi Lihong , Griffith Obi L. , Gray Joe W. , Carraway Kermit L. , Sweeney Colleen
Published: April 2023

PDF file - 1.19MB
Supplementary Figure 3 from Lrig1 Is an Estrogen-Regulated Growth Suppressor and Correlates with Longer Relapse-Free Survival in ERα-Positive Breast Cancer
Authors: Krig Sheryl R. , Frietze Seth , Simion Catalina , Miller Jamie K. , Fry Will H.D. , Rafidi Hanine , Kotelawala Lakmal , Qi Lihong , Griffith Obi L. , Gray Joe W. , Carraway Kermit L. , Sweeney Colleen
Published: April 2023

PDF file - 2.38MB
Supplementary Figure Legends 1-4 from Resveratrol Inhibits Proliferation and Survival of Epstein Barr Virus–Infected Burkitt's Lymphoma Cells Depending on Viral Latency Program
Authors: De Leo Alessandra , Arena Giuseppe , Stecca Claudia , Raciti Marisa , Mattia Elena
Published: April 2023

PDF File - (92K)
Supplementary Figure 2 from Lrig1 Is an Estrogen-Regulated Growth Suppressor and Correlates with Longer Relapse-Free Survival in ERα-Positive Breast Cancer
Authors: Krig Sheryl R. , Frietze Seth , Simion Catalina , Miller Jamie K. , Fry Will H.D. , Rafidi Hanine , Kotelawala Lakmal , Qi Lihong , Griffith Obi L. , Gray Joe W. , Carraway Kermit L. , Sweeney Colleen
Published: April 2023

PDF file - 2.41MB
Supplementary Figure 1 from Lrig1 Is an Estrogen-Regulated Growth Suppressor and Correlates with Longer Relapse-Free Survival in ERα-Positive Breast Cancer
Authors: Krig Sheryl R. , Frietze Seth , Simion Catalina , Miller Jamie K. , Fry Will H.D. , Rafidi Hanine , Kotelawala Lakmal , Qi Lihong , Griffith Obi L. , Gray Joe W. , Carraway Kermit L. , Sweeney Colleen
Published: April 2023

Pdf file - 965K
Supplementary Movie S3 from Critical Role of Endogenous Heme Oxygenase 1 as a Tuner of the Invasive Potential of Prostate Cancer Cells
Authors: Gueron Geraldine , De Siervi Adriana , Ferrando Mercedes , Salierno Marcelo , De Luca Paola , Elguero Belen , Meiss Roberto , Navone Nora , Vazquez Elba S.
Published: April 2023

Supplementary Movie S3 from Critical Role of Endogenous Heme Oxygenase 1 as a Tuner of the Invasive Potential of Prostate Cancer Cells
Supplementary Figure 1 from Resveratrol Inhibits Proliferation and Survival of Epstein Barr Virus–Infected Burkitt's Lymphoma Cells Depending on Viral Latency Program
Authors: De Leo Alessandra , Arena Giuseppe , Stecca Claudia , Raciti Marisa , Mattia Elena
Published: April 2023

PDF File - (754K) - Expression pattern of EBV latent genes in BL cell lines and LCLs. 100 μg of cell lysate from each cell lines were resolved on a 12% SDS-PAGE, transferred to membranes and hybridized with the following antibodies: EBNA1 (OT1X CytoBarr, 1:1000); EBNA2 (PE2), and EBNA3C (E3cA10) kindly provided by Dr. M. Rowe, were used 1:2000); LMP1 (S12 Pharmingen, 1:7500); LMP2A (14B7 Santa Cruz, 1:200). Specific signals were visualized by ECL.
Supplementary Table S2 from JAG2 Induction in Hypoxic Tumor Cells Alters Notch Signaling and Enhances Endothelial Cell Tube Formation
Authors: Pietras Alexander , von Stedingk Kristoffer , Lindgren David , Påhlman Sven , Axelson Håkan
Published: April 2023

Supplementary Table S2 from JAG2 Induction in Hypoxic Tumor Cells Alters Notch Signaling and Enhances Endothelial Cell Tube Formation
Supplementary Movie S1 from Critical Role of Endogenous Heme Oxygenase 1 as a Tuner of the Invasive Potential of Prostate Cancer Cells
Authors: Gueron Geraldine , De Siervi Adriana , Ferrando Mercedes , Salierno Marcelo , De Luca Paola , Elguero Belen , Meiss Roberto , Navone Nora , Vazquez Elba S.
Published: April 2023

Supplementary Movie S1 from Critical Role of Endogenous Heme Oxygenase 1 as a Tuner of the Invasive Potential of Prostate Cancer Cells
Supplementary Data from Critical Role of Endogenous Heme Oxygenase 1 as a Tuner of the Invasive Potential of Prostate Cancer Cells
Authors: Gueron Geraldine , De Siervi Adriana , Ferrando Mercedes , Salierno Marcelo , De Luca Paola , Elguero Belen , Meiss Roberto , Navone Nora , Vazquez Elba S.
Published: April 2023

Supplementary Data from Critical Role of Endogenous Heme Oxygenase 1 as a Tuner of the Invasive Potential of Prostate Cancer Cells
Supplementary Data from Rictor Phosphorylation on the Thr-1135 Site Does Not Require Mammalian Target of Rapamycin Complex 2
Authors: Boulbes Delphine , Chen Chien-Hung , Shaikenov Tattym , Agarwal Nitin K. , Peterson Timothy R. , Addona Terri A. , Keshishian Hasmik , Carr Steven A. , Magnuson Mark A. , Sabatini David M. , Sarbassov Dos D.
Published: April 2023

Supplementary Data from Rictor Phosphorylation on the Thr-1135 Site Does Not Require Mammalian Target of Rapamycin Complex 2
Supplementary Data from HuR-Mediated Control of C/EBPβ mRNA Stability and Translation in ALK-Positive Anaplastic Large Cell Lymphomas
Authors: Bergalet Julie , Fawal Mohamad , Lopez Celine , Desjobert Cecile , Lamant Laurence , Delsol Georges , Morello Dominique , Espinos Estelle
Published: April 2023

Supplementary Figures S1-S3; Supplementary Table S1.
Supplementary Figures S1-S3 from Functional Inactivation of Endogenous MDM2 and CHIP by HSP90 Causes Aberrant Stabilization of Mutant p53 in Human Cancer Cells
Authors: Li Dun , Marchenko Natalia D. , Schulz Ramona , Fischer Victoria , Velasco-Hernandez Talia , Talos Flaminia , Moll Ute M.
Published: April 2023

Supplementary Figures S1-S3 from Functional Inactivation of Endogenous MDM2 and CHIP by HSP90 Causes Aberrant Stabilization of Mutant p53 in Human Cancer Cells
Supplementary Data from Sox7 Is an Independent Checkpoint for β-Catenin Function in Prostate and Colon Epithelial Cells
Authors: Guo Lizheng , Zhong Diansheng , Lau Stephen , Liu Xiuju , Dong Xue-Yuan , Sun Xiaodong , Yang Vincent W. , Vertino Paula M. , Moreno Carlos S. , Varma Vijay , Dong Jin-Tang , Zhou Wei
Published: April 2023

Supplementary Data from Sox7 Is an Independent Checkpoint for β-Catenin Function in Prostate and Colon Epithelial Cells
Supplementary Figures S1-S6 from Mitochondrial c-Jun NH2-Terminal Kinase Prevents the Accumulation of Reactive Oxygen Species and Reduces Necrotic Damage in Neural Tumor Cells that Lack Trophic Support
Authors: López-Sánchez Noelia , Rodríguez José-Rodrigo , Frade José María
Published: April 2023

Supplementary Figures S1-S6 from Mitochondrial c-Jun NH2-Terminal Kinase Prevents the Accumulation of Reactive Oxygen Species and Reduces Necrotic Damage in Neural Tumor Cells that Lack Trophic Support
Supplementary Table S1 from Baseline Gene Expression Predicts Sensitivity to Gefitinib in Non–Small Cell Lung Cancer Cell Lines
Authors: Coldren Christopher D. , Helfrich Barbara A. , Witta Samir E. , Sugita Michio , Lapadat Razvan , Zeng Chan , Barón Anna , Franklin Wilbur A. , Hirsch Fred R. , Geraci Mark W. , Bunn Paul A.
Published: April 2023

Supplementary Table S1 from Baseline Gene Expression Predicts Sensitivity to Gefitinib in Non–Small Cell Lung Cancer Cell Lines
Supplementary Data from Molecular Mechanisms of Liver Carcinogenesis in the Mdr2-Knockout Mice
Authors: Katzenellenbogen Mark , Mizrahi Lina , Pappo Orit , Klopstock Naama , Olam Devorah , Jacob-Hirsch Jasmine , Amariglio Ninette , Rechavi Gideon , Domany Eytan , Galun Eithan , Goldenberg Daniel
Published: April 2023

Supplementary Data from Molecular Mechanisms of Liver Carcinogenesis in the Mdr2-Knockout Mice
Supplementary Table S3 from Microarray Analysis of Bleomycin-Exposed Lymphoblastoid Cells for Identifying Cancer Susceptibility Genes
Authors: Cloos Jacqueline , de Boer Wim P.H. , Snel Mireille H.J. , van den IJssel Paul , Ylstra Bauke , Leemans C. René , Brakenhoff Ruud H. , Braakhuis Boudewijn J.M.
Published: April 2023

Supplementary Table S3 from Microarray Analysis of Bleomycin-Exposed Lymphoblastoid Cells for Identifying Cancer Susceptibility Genes
Supplementary Table S1 from Microarray Analysis of Bleomycin-Exposed Lymphoblastoid Cells for Identifying Cancer Susceptibility Genes
Authors: Cloos Jacqueline , de Boer Wim P.H. , Snel Mireille H.J. , van den IJssel Paul , Ylstra Bauke , Leemans C. René , Brakenhoff Ruud H. , Braakhuis Boudewijn J.M.
Published: April 2023

Gene list: bleo comparison
Supplementary Table S5 from Ataxia Telangiectasia-Mutated–Dependent DNA Damage Checkpoint Functions Regulate Gene Expression in Human Fibroblasts
Authors: Zhou Tong , Chou Jeff , Zhou Yingchun , Simpson Dennis A. , Cao Feng , Bushel Pierre R. , Paules Richard S. , Kaufmann William K.
Published: April 2023

Supplementary Table S5 from Ataxia Telangiectasia-Mutated–Dependent DNA Damage Checkpoint Functions Regulate Gene Expression in Human Fibroblasts
Supplementary Table S4 from Ataxia Telangiectasia-Mutated–Dependent DNA Damage Checkpoint Functions Regulate Gene Expression in Human Fibroblasts
Authors: Zhou Tong , Chou Jeff , Zhou Yingchun , Simpson Dennis A. , Cao Feng , Bushel Pierre R. , Paules Richard S. , Kaufmann William K.
Published: April 2023

Supplementary Table S4 from Ataxia Telangiectasia-Mutated–Dependent DNA Damage Checkpoint Functions Regulate Gene Expression in Human Fibroblasts
Supplementary Table S3 from Ataxia Telangiectasia-Mutated–Dependent DNA Damage Checkpoint Functions Regulate Gene Expression in Human Fibroblasts
Authors: Zhou Tong , Chou Jeff , Zhou Yingchun , Simpson Dennis A. , Cao Feng , Bushel Pierre R. , Paules Richard S. , Kaufmann William K.
Published: April 2023

Supplementary Table S3 from Ataxia Telangiectasia-Mutated–Dependent DNA Damage Checkpoint Functions Regulate Gene Expression in Human Fibroblasts
Supplementary Table S2 from Ataxia Telangiectasia-Mutated–Dependent DNA Damage Checkpoint Functions Regulate Gene Expression in Human Fibroblasts
Authors: Zhou Tong , Chou Jeff , Zhou Yingchun , Simpson Dennis A. , Cao Feng , Bushel Pierre R. , Paules Richard S. , Kaufmann William K.
Published: April 2023

Supplementary Table S2 from Ataxia Telangiectasia-Mutated–Dependent DNA Damage Checkpoint Functions Regulate Gene Expression in Human Fibroblasts
Supplementary Data 1 from Genomic Analysis of a Spontaneous Model of Breast Cancer Metastasis to Bone Reveals a Role for the Extracellular Matrix1
Authors: Eckhardt Bedrich L. , Parker Belinda S. , van Laar Ryan K. , Restall Christina M. , Natoli Anthony L. , Tavaria Michael D. , Stanley Kym L. , Sloan Erica K. , Moseley Jane M. , Anderson Robin L.
Published: April 2023

Primer sequences used in realtime quantitative PCR
Supplementary Table S3 from Integrative Genomic Analysis of Small-Cell Lung Carcinoma Reveals Correlates of Sensitivity to Bcl-2 Antagonists and Uncovers Novel Chromosomal Gains
Authors: Olejniczak Edward T. , Van Sant Charles , Anderson Mark G. , Wang Gang , Tahir Stephen K. , Sauter Guido , Lesniewski Rick , Semizarov Dimitri
Published: April 2023

Supplementary Table S3 from Integrative Genomic Analysis of Small-Cell Lung Carcinoma Reveals Correlates of Sensitivity to Bcl-2 Antagonists and Uncovers Novel Chromosomal Gains
Supplementary Figure S3 from A Dominant-Negative Form of the Major Human Abasic Endonuclease Enhances Cellular Sensitivity to Laboratory and Clinical DNA-Damaging Agents
Authors: McNeill Daniel R. , Wilson David M.
Published: April 2023

Supplementary Figure S3 from A Dominant-Negative Form of the Major Human Abasic Endonuclease Enhances Cellular Sensitivity to Laboratory and Clinical DNA-Damaging Agents
Supplementary Figure S1 from Poly(ADP-Ribose) Polymerase 1 Promotes Tumor Cell Survival by Coactivating Hypoxia-Inducible Factor-1–Dependent Gene Expression
Authors: Elser Michael , Borsig Lubor , Hassa Paul O. , Erener Suheda , Messner Simon , Valovka Taras , Keller Stephan , Gassmann Max , Hottiger Michael O.
Published: April 2023

Supplementary Figure S1 from Poly(ADP-Ribose) Polymerase 1 Promotes Tumor Cell Survival by Coactivating Hypoxia-Inducible Factor-1–Dependent Gene Expression
Supplementary Figures S1-S4 from Down Syndrome Candidate Region 1 Isoform 1 Mediates Angiogenesis through the Calcineurin-NFAT Pathway
Authors: Qin Liuliang , Zhao Dezheng , Liu Xin , Nagy Janice A. , Hoang Mien Van , Brown Lawrence F. , Dvorak Harold F. , Zeng Huiyan
Published: April 2023

Supplementary Figures S1-S4 from Down Syndrome Candidate Region 1 Isoform 1 Mediates Angiogenesis through the Calcineurin-NFAT Pathway
Supplementary Data from Expression of PGK1 by Prostate Cancer Cells Induces Bone Formation
Authors: Jung Younghun , Shiozawa Yusuke , Wang Jianhua , Wang Jingcheng , Wang Zhuo , Pedersen Elisabeth A. , Lee Clara H. , Hall Christopher L. , Hogg Phillip J. , Krebsbach Paul H. , Keller Evan T. , Taichman Russell S.
Published: April 2023

Supplementary Data from Expression of PGK1 by Prostate Cancer Cells Induces Bone Formation
Supplementary Figures S1 & S2 from Histone Deacetylase Inhibitors (HDI) Cause DNA Damage in Leukemia Cells: A Mechanism for Leukemia-Specific HDI-Dependent Apoptosis?
Authors: Gaymes Terry J. , Padua Rose Ann , Pla Marika , Orr Stephen , Omidvar Nader , Chomienne Christine , Mufti Ghulam J. , Rassool Feyruz V.
Published: April 2023

Supplementary Figures S1 & S2 from Histone Deacetylase Inhibitors (HDI) Cause DNA Damage in Leukemia Cells: A Mechanism for Leukemia-Specific HDI-Dependent Apoptosis?
Supplementary Table S5 from Gene Expression Changes in an Animal Melanoma Model Correlate with Aggressiveness of Human Melanoma Metastases
Authors: Xu Lei , Shen Steven S. , Hoshida Yujin , Subramanian Aravind , Ross Ken , Brunet Jean-Philippe , Wagner Stephan N. , Ramaswamy Sridhar , Mesirov Jill P. , Hynes Richard O.
Published: April 2023

Supplementary Table S5 from Gene Expression Changes in an Animal Melanoma Model Correlate with Aggressiveness of Human Melanoma Metastases
Supplementary Figure Legends from Histone Deacetylase Inhibitors (HDI) Cause DNA Damage in Leukemia Cells: A Mechanism for Leukemia-Specific HDI-Dependent Apoptosis?
Authors: Gaymes Terry J. , Padua Rose Ann , Pla Marika , Orr Stephen , Omidvar Nader , Chomienne Christine , Mufti Ghulam J. , Rassool Feyruz V.
Published: April 2023

Supplementary Figure Legends from Histone Deacetylase Inhibitors (HDI) Cause DNA Damage in Leukemia Cells: A Mechanism for Leukemia-Specific HDI-Dependent Apoptosis?
Supplementary Table S4 from Identification and Validation of Colorectal Neoplasia–Specific Methylation Markers for Accurate Classification of Disease
Authors: Model Fabian , Osborn Neal , Ahlquist David , Gruetzmann Robert , Molnar Bela , Sipos Ferenc , Galamb Orsolya , Pilarsky Christian , Saeger Hans-Detlev , Tulassay Zsolt , Hale Kari , Mooney Suzanne , Lograsso Joseph , Adorjan Peter , Lesche Ralf , Dessauer Andreas , Kleiber Joerg , Porstmann Baerbel , Sledziewski Andrew , Lofton-Day Catherine
Published: April 2023

Supplementary Table S4 from Identification and Validation of Colorectal Neoplasia–Specific Methylation Markers for Accurate Classification of Disease
Supplementary Table S2 from Gene Expression Changes in an Animal Melanoma Model Correlate with Aggressiveness of Human Melanoma Metastases
Authors: Xu Lei , Shen Steven S. , Hoshida Yujin , Subramanian Aravind , Ross Ken , Brunet Jean-Philippe , Wagner Stephan N. , Ramaswamy Sridhar , Mesirov Jill P. , Hynes Richard O.
Published: April 2023

Supplementary Table S2 from Gene Expression Changes in an Animal Melanoma Model Correlate with Aggressiveness of Human Melanoma Metastases
Supplementary Table S2 from Identification and Validation of Colorectal Neoplasia–Specific Methylation Markers for Accurate Classification of Disease
Authors: Model Fabian , Osborn Neal , Ahlquist David , Gruetzmann Robert , Molnar Bela , Sipos Ferenc , Galamb Orsolya , Pilarsky Christian , Saeger Hans-Detlev , Tulassay Zsolt , Hale Kari , Mooney Suzanne , Lograsso Joseph , Adorjan Peter , Lesche Ralf , Dessauer Andreas , Kleiber Joerg , Porstmann Baerbel , Sledziewski Andrew , Lofton-Day Catherine
Published: April 2023

Supplementary Table S2 from Identification and Validation of Colorectal Neoplasia–Specific Methylation Markers for Accurate Classification of Disease
Supplementary Table S1 from Identification and Validation of Colorectal Neoplasia–Specific Methylation Markers for Accurate Classification of Disease
Authors: Model Fabian , Osborn Neal , Ahlquist David , Gruetzmann Robert , Molnar Bela , Sipos Ferenc , Galamb Orsolya , Pilarsky Christian , Saeger Hans-Detlev , Tulassay Zsolt , Hale Kari , Mooney Suzanne , Lograsso Joseph , Adorjan Peter , Lesche Ralf , Dessauer Andreas , Kleiber Joerg , Porstmann Baerbel , Sledziewski Andrew , Lofton-Day Catherine
Published: April 2023

Supplementary Table S1 from Identification and Validation of Colorectal Neoplasia–Specific Methylation Markers for Accurate Classification of Disease
Supplementary Table S3 from Breast Cancer Molecular Signatures as Determined by SAGE: Correlation with Lymph Node Status
Authors: Abba Martín C. , Sun Hongxia , Hawkins Kathleen A. , Drake Jeffrey A. , Hu Yuhui , Nunez Maria I. , Gaddis Sally , Shi Tao , Horvath Steve , Sahin Aysegul , Aldaz C. Marcelo
Published: April 2023

Supplementary Table S3 from Breast Cancer Molecular Signatures as Determined by SAGE: Correlation with Lymph Node Status
Supplementary Table S2 from Breast Cancer Molecular Signatures as Determined by SAGE: Correlation with Lymph Node Status
Authors: Abba Martín C. , Sun Hongxia , Hawkins Kathleen A. , Drake Jeffrey A. , Hu Yuhui , Nunez Maria I. , Gaddis Sally , Shi Tao , Horvath Steve , Sahin Aysegul , Aldaz C. Marcelo
Published: April 2023

Supplementary Table S2 from Breast Cancer Molecular Signatures as Determined by SAGE: Correlation with Lymph Node Status
Supplementary Table S1 from Breast Cancer Molecular Signatures as Determined by SAGE: Correlation with Lymph Node Status
Authors: Abba Martín C. , Sun Hongxia , Hawkins Kathleen A. , Drake Jeffrey A. , Hu Yuhui , Nunez Maria I. , Gaddis Sally , Shi Tao , Horvath Steve , Sahin Aysegul , Aldaz C. Marcelo
Published: April 2023

Supplementary Table S1 from Breast Cancer Molecular Signatures as Determined by SAGE: Correlation with Lymph Node Status
Supplementary Figures S1-S6 from Phosphatidylethanol Accumulation Promotes Intestinal Hyperplasia by Inducing ZONAB-Mediated Cell Density Increase in Response to Chronic Ethanol Exposure
Authors: Pannequin Julie , Delaunay Nathalie , Darido Charbel , Maurice Tangui , Crespy Philippe , Frohman Michael A. , Balda Maria S. , Matter Karl , Joubert Dominique , Bourgaux Jean-François , Bali Jean-Pierre , Hollande Frédéric
Published: April 2023

Supplementary Figures S1-S6 from Phosphatidylethanol Accumulation Promotes Intestinal Hyperplasia by Inducing ZONAB-Mediated Cell Density Increase in Response to Chronic Ethanol Exposure
Supplementary Data from Src Induces Urokinase Receptor Gene Expression and Invasion/Intravasation via Activator Protein-1/p-c-Jun in Colorectal Cancer
Authors: Leupold Jörg H. , Asangani Irfan , Maurer Gabriele D. , Lengyel Ernst , Post Stefan , Allgayer Heike
Published: April 2023

Supplementary Figures S1-S2; Supplementary Table S1.
Supplementary Figures S1-S2 from HOP/OB1/NECC1 Promoter DNA Is Frequently Hypermethylated and Involved in Tumorigenic Ability in Esophageal Squamous Cell Carcinoma
Authors: Yamashita Keishi , Kim Myoung Sook , Park Hannah Lui , Tokumaru Yutaka , Osada Motonobu , Inoue Hiroshi , Mori Masaki , Sidransky David
Published: April 2023

Supplementary Figures S1-S2 from HOP/OB1/NECC1 Promoter DNA Is Frequently Hypermethylated and Involved in Tumorigenic Ability in Esophageal Squamous Cell Carcinoma
Supplementary Figure S1 from Fbw7 Isoform Interaction Contributes to Cyclin E Proteolysis
Authors: Zhang Wei , Koepp Deanna M.
Published: April 2023

Supplementary Figure S1 from Fbw7 Isoform Interaction Contributes to Cyclin E Proteolysis
Supplementary Table S1 from Phosphatidylinositol-3-OH Kinase or RAS Pathway Mutations in Human Breast Cancer Cell Lines
Authors: Hollestelle Antoinette , Elstrodt Fons , Nagel Jord H.A. , Kallemeijn Wouter W. , Schutte Mieke
Published: April 2023

Supplementary Table S1 from Phosphatidylinositol-3-OH Kinase or RAS Pathway Mutations in Human Breast Cancer Cell Lines
Supplementary article from NR0B1 Is Required for the Oncogenic Phenotype Mediated by EWS/FLI in Ewing's Sarcoma
Authors: Kinsey Michelle , Smith Richard , Lessnick Stephen L.
Published: April 2023

Supplementary Cancer Cell article reference
Supplementary Methods from NR0B1 Is Required for the Oncogenic Phenotype Mediated by EWS/FLI in Ewing's Sarcoma
Authors: Kinsey Michelle , Smith Richard , Lessnick Stephen L.
Published: April 2023

Supplementary Methods from NR0B1 Is Required for the Oncogenic Phenotype Mediated by EWS/FLI in Ewing's Sarcoma
Supplementary Data 2 from NR0B1 Is Required for the Oncogenic Phenotype Mediated by EWS/FLI in Ewing's Sarcoma
Authors: Kinsey Michelle , Smith Richard , Lessnick Stephen L.
Published: April 2023

Supplementary Data 2 from NR0B1 Is Required for the Oncogenic Phenotype Mediated by EWS/FLI in Ewing's Sarcoma
Supplementary Figures S1-S3 from FLICE-Like Inhibitory Protein Blocks Transforming Growth Factor β1–Induced Caspase Activation and Apoptosis in Prostate Epithelial Cells
Authors: Nastiuk Kent L. , Yoo Kiwon , Lo Karen , Su Kevin , Yeung Patricia , Kutaka Julia , Danielpour David , Krolewski John J.
Published: April 2023

Supplementary Figures S1-S3 from FLICE-Like Inhibitory Protein Blocks Transforming Growth Factor β1–Induced Caspase Activation and Apoptosis in Prostate Epithelial Cells
Supplementary Figures S1-S2 from Wwox Suppresses Prostate Cancer Cell Growth through Modulation of ErbB2-Mediated Androgen Receptor Signaling
Authors: Qin Haiyan R. , Iliopoulos Dimitrios , Nakamura Tatsuya , Costinean Stefan , Volinia Stefano , Druck Teresa , Sun Jin , Okumura Hiroshi , Huebner Kay
Published: April 2023

Supplementary Figures S1-S2 from Wwox Suppresses Prostate Cancer Cell Growth through Modulation of ErbB2-Mediated Androgen Receptor Signaling
Supplementary Table 2 from Molecular Characterization of the Transition to Malignancy in a Genetically Engineered Mouse-Based Model of Ductal Carcinoma In situ1
Authors: Namba Ruria , Maglione Jeannie E. , Young Lawrence J.T. , Borowsky Alexander D. , Cardiff Robert D. , MacLeod Carol L. , Gregg Jeffrey P.
Published: April 2023

Supplementary Table 2 from Molecular Characterization of the Transition to Malignancy in a Genetically Engineered Mouse-Based Model of Ductal Carcinoma In situ1
Supplementary Tables 1-7 from Comprehensive Profiling of 8p11-12 Amplification in Breast Cancer
Authors: Gelsi-Boyer Véronique , Orsetti Béatrice , Cervera Nathalie , Finetti Pascal , Sircoulomb Fabrice , Rougé Carole , Lasorsa Laurence , Letessier Anne , Ginestier Christophe , Monville Florence , Esteyriès Séverine , Adélaïde José , Esterni Benjamin , Henry Catherine , Ethier Stephen P. , Bibeau Frédéric , Mozziconacci Marie-Joëlle , Charafe-Jauffret Emmanuelle , Jacquemier Jocelyne , Bertucci François , Birnbaum Daniel , Theillet Charles , Chaffanet Max
Published: April 2023

Supplementary Tables 1-7 from Comprehensive Profiling of 8p11-12 Amplification in Breast Cancer
Supplementary Data, Chaturvedi, et al. from MUC4 Mucin Potentiates Pancreatic Tumor Cell Proliferation, Survival, and Invasive Properties and Interferes with Its Interaction to Extracellular Matrix Proteins
Authors: Chaturvedi Pallavi , Singh Ajay P. , Moniaux Nicolas , Senapati Shantibhushan , Chakraborty Subhankar , Meza Jane L. , Batra Surinder K.
Published: April 2023

Supplementary Figures S1-S3; Supplementary Materials and Methods; Supplementary Figure Legend; Supplementary Table S1
Supplementary Data from The Role of MET Activation in Determining the Sensitivity to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors
Authors: Rho Jin Kyung , Choi Yun Jung , Lee Jin Kyung , Ryoo Baek-Yeol , Na Im Il , Yang Sung Hyun , Lee Seung Sook , Kim Cheol Hyeon , Yoo Young Do , Lee Jae Cheol
Published: April 2023

Supplementary Data from The Role of MET Activation in Determining the Sensitivity to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors
Data from Evolutionary Characteristics and Immunologic Divergence of Lung and Brain Metastasis Lesions in NSCLC
Authors: Xie Tongji , Liu Zhenghao , Li Yan , Wang Shouzheng , Zhai Yixin , Teng Fei , Hao Xuezhi , Wang Yan , Wang Hongyu , Zhang Xin , Wu Xi , Ying Jianming , Li Junling , Zhang Ye , Deng Yuefei , Xing Puyuan
Published: April 2023

Abstract
Brain metastases (BM) is one of the main reasons for lung cancer-related deaths but lack prediction methods. Many patients with BMs do not benefit from immunotherapy. A comprehensive genomic analysis of matched primary tumors (PT) and their BM lesions may provide new insight into the evolutionary and immune characteristics. To describe evolutionary features and immune characteristic differences, we analyzed whole-exome sequencing data for 28 paired PT and BM samples from 14 patients with non-small cell lung cancer. In addition, we used another 26 matched PT and BM samples as a validation cohort. We found that total mutational signatures were relatively consistent between paired primary and brain metastatic tumors. Nevertheless, the shared mutations of the two lesions were fewer than the mutations present in each of the lesions alone. In the process of BM, driver genes undergo evolutionary branches. Typical driver genes, including EGFR and TP53, appear relatively conserved throughout evolution; however, specific signals are enriched in BM lesions. We found several main characteristics of lung cancer BMs that were different from primary lung cancer, such as genomic instability, novel driver genes, tumor mutation burden, and BM lesion private neoantigens. In addition, the estimated timing of dissemination showed that BMs might occur early in lung cancer.
Implications:
Mechanistic insight from this study provides new insight into the biology of the metastatic brain process and a new beneficial approach for preventing and treating lung cancer BMs.
Data from Malignant Progression of an Ancestral Bone Marrow Clone Harboring a CIC-NUTM2A Fusion in Isolated Myeloid Sarcoma
Authors: Kamens Jennifer L. , Dang Jinjun , Shaw Timothy I. , Gout Alexander M. , Newman Scott , Hagiwara Kohei , Smith Amelia M.R. , Obermayer Alyssa N. , Aldridge Sarah , Ma Jing , Zhang Yang , Wu Gang , Leventaki Vasiliki , Santiago Teresa , Raimondi Susana , Nakitandwe Joy , Pappo Alberto , Li Chunliang , Zhang Jinghui , Gruber Tanja A.
Published: April 2023

Abstract
Myeloid sarcoma is a rare condition consisting of extramedullary myeloid blasts found in association with acute myeloid leukemia or, in the absence of bone marrow involvement. We identified an infant with isolated myeloid sarcoma whose bone marrow was negative for involvement by flow cytometry. Sequencing revealed the fusion oncogene CIC-NUTM2A and identified the sarcoma to be clonally evolved from the bone marrow, which carried the fusion despite the absence of pathology. Murine modeling confirmed the ability of the fusion to transform hematopoietic cells and identified receptor tyrosine kinase (RTK) signaling activation consistent with disruption of the CIC transcriptional repressor. These findings extend the definition of CIC-rearranged malignancies to include hematologic disease, provide insight into the mechanism of oncogenesis, and demonstrate the importance of molecular analysis and tracking of bone marrow involvement over the course of treatment in myeloid sarcoma, including patients that lack flow cytometric evidence of leukemia at diagnosis.
Implications:
This study illustrates molecular involvement of phenotypically normal bone marrow in myeloid sarcoma, which has significant implications in clinical care. Further, it extends the definition of CIC-rearrangements to include hematologic malignancies and shows evidence of RTK activation that may be exploited therapeutically in cancer(s) driven by these fusions.
Data from Functional Genomics Approach Identifies Novel Signaling Regulators of TGFα Ectodomain Shedding
Authors: Wilson Jennifer L. , Kefaloyianni Eirini , Stopfer Lauren , Harrison Christina , Sabbisetti Venkata S. , Fraenkel Ernest , Lauffenburger Douglas A. , Herrlich Andreas
Published: April 2023

Abstract
Ectodomain shedding of cell-surface precursor proteins by metalloproteases generates important cellular signaling molecules. Of importance for disease is the release of ligands that activate the EGFR, such as TGFα, which is mostly carried out by ADAM17 [a member of the A-disintegrin and metalloprotease (ADAM) domain family]. EGFR ligand shedding has been linked to many diseases, in particular cancer development, growth and metastasis, as well as resistance to cancer therapeutics. Excessive EGFR ligand release can outcompete therapeutic EGFR inhibition or the inhibition of other growth factor pathways by providing bypass signaling via EGFR activation. Drugging metalloproteases directly have failed clinically because it indiscriminately affected shedding of numerous substrates. It is therefore essential to identify regulators for EGFR ligand cleavage. Here, integration of a functional shRNA genomic screen, computational network analysis, and dedicated validation tests succeeded in identifying several key signaling pathways as novel regulators of TGFα shedding in cancer cells. Most notably, a cluster of genes with NFκB pathway regulatory functions was found to strongly influence TGFα release, albeit independent of their NFκB regulatory functions. Inflammatory regulators thus also govern cancer cell growth–promoting ectodomain cleavage, lending mechanistic understanding to the well-known connection between inflammation and cancer.

Implications: Using genomic screens and network analysis, this study defines targets that regulate ectodomain shedding and suggests new treatment opportunities for EGFR-driven cancers. Mol Cancer Res; 16(1); 147–61. ©2017 AACR.