bluuebunny/crossref_metadata_2025 huggingface dataset:
Potential of nintedanib in treatment of progressive fibrosing interstitial lung diseases
Authors: Wollin Lutz , Distler Jörg H.W. , Redente Elizabeth F. , Riches David W.H. , Stowasser Susanne , Schlenker-Herceg Rozsa , Maher Toby M. , Kolb Martin
Published: July 2019

A proportion of patients with fibrosing interstitial lung diseases (ILDs) develop a progressive phenotype characterised by decline in lung function, worsening quality of life and early mortality. Other than idiopathic pulmonary fibrosis (IPF), there are no approved drugs for fibrosing ILDs and a poor evidence base to support current treatments. Fibrosing ILDs with a progressive phenotype show commonalities in clinical behaviour and in the pathogenic mechanisms that drive disease worsening. Nintedanib is an intracellular inhibitor of tyrosine kinases that has been approved for treatment of IPF and has recently been shown to reduce the rate of lung function decline in patients with ILD associated with systemic sclerosis (SSc-ILD).In vitrodata demonstrate that nintedanib inhibits several steps in the initiation and progression of lung fibrosis, including the release of pro-inflammatory and pro-fibrotic mediators, migration and differentiation of fibrocytes and fibroblasts, and deposition of extracellular matrix. Nintedanib also inhibits the proliferation of vascular cells. Studies in animal models with features of fibrosing ILDs such as IPF, SSc-ILD, rheumatoid arthritis-ILD, hypersensitivity pneumonitis and silicosis demonstrate that nintedanib has anti-fibrotic activity irrespective of the trigger for the lung pathology. This suggests that nintedanib inhibits fundamental processes in the pathogenesis of fibrosis. A trial of nintedanib in patients with progressive fibrosing ILDs other than IPF (INBUILD) will report results in 2019.
A double-blind, placebo-controlled, randomised trial to assess the effect of liraglutide on ectopic fat accumulation in South Asian type 2 diabetes patients
Authors: van Eyk Huub J. , Paiman Elisabeth H. M. , Bizino Maurice B. , de Heer Paul , Geelhoed-Duijvestijn Petronella H. , Kharagjitsingh Aan V. , Smit Johannes W. A. , Lamb Hildo J. , Rensen Patrick C. N. , Jazet Ingrid M.
Published: July 2019

Background

South Asians have a high risk to develop type 2 diabetes, which may be related to substantial ectopic fat deposition. Since glucagon-like peptide-1 analogues can reduce ectopic fat accumulation, the aim of the present study was to assess the effect of treatment with liraglutide for 26 weeks on ectopic fat deposition and HbA1c in South Asian patients with type 2 diabetes.

Methods

In a placebo-controlled trial, 47 South Asian patients with type 2 diabetes were randomly assigned to treatment with liraglutide (1.8 mg/day) or placebo added to standard care. At baseline and after 26 weeks of treatment we assessed abdominal subcutaneous, visceral, epicardial and paracardial adipose tissue volume using MRI. Furthermore, myocardial and hepatic triglyceride content were examined with proton magnetic resonance spectroscopy.

Results

In the intention-to-treat analysis, liraglutide decreased body weight compared to placebo (− 3.9 ± 3.6 kg vs − 0.6 ± 2.2 kg; mean change from baseline (liraglutide vs placebo): − 3.5 kg; 95% CI [− 5.3, − 1.8]) without significant effects on the different adipose tissue compartments. HbA1c was decreased in both groups without between group differences. In the per-protocol analysis, liraglutide did decrease visceral adipose tissue volume compared to placebo (− 23 ± 27 cm2 vs − 2 ± 17 cm2; mean change from baseline (liraglutide vs placebo): − 17 cm2; 95% CI [− 32, − 3]). Furthermore, HbA1c was decreased by liraglutide compared to placebo (− 1.0 ± 0.8% (− 10.5 ± 9.1 mmol/mol)) vs (− 0.6 ± 0.8% (− 6.1 ± 8.8 mmol/mol)), with a between group difference (mean change from baseline (liraglutide vs placebo): − 0.6% (− 6.5 mmol/mol); 95% CI [− 1.1, − 0.1 (− 11.5, − 1.5)]). Interestingly, the decrease of visceral adipose tissue volume was associated with the reduction of HbA1c (β: 0.165 mmol/mol (0.015%) per 1 cm2 decrease of visceral adipose tissue volume; 95% CI [0.062, 0.267 (0.006, 0.024%)]).

Conclusions

While the intention-to-treat analysis did not show effects of liraglutide on ectopic fat and HbA1c, per-protocol analysis showed that liraglutide decreases visceral adipose tissue volume, which was associated with improved glycaemic control in South Asians.

Trial registration NCT02660047 (clinicaltrials.gov). Registered 21 January 2016
Epidermodysplasia verruciformis: revision of a model of carcinogenic disease
Authors: da Cruz Silva Lana Luiza , de Oliveira Walmar Roncalli Pereira , Sotto Mirian Nacagami
Published: July 2019

Background

This review addresses current issues regarding epidermodysplasia verruciformis (EV), which are relevant in clinical practice and to comprehend the mechanisms by which human papillomavirus (HPV) acts in cutaneous carcinogenesis.

Main body

EV is an unusual genodermatosis, related to beta-HPV, with high risk for developing skin cancer. Clinical manifestations begin in childhood and they are characterized by flat warts, pityriasis versicolor-like macules and seborrheic keratoses lesions. Up to 50% of EV patients develop nonmelanoma skin cancer in sun exposed areas, mainly squamous cell carcinomas (SCC). Unlike genital carcinomas associated to alpha-HPV, in which transcriptionally active viral genomes invariably occurs, the EV-HPV seems to act by interaction with the host cell, the ultraviolet radiation and immunosuppression to result in carcinogenesis. The EV diagnosis is clinical and it can be confirmed by characteristic histopathological findings and EV-HPV identification. Until now, there is no effective treatment for EV. EV patients need regular clinical follow-up for early detection and treatment of cutaneous carcinomas.

Conclusion

Despite the rarity of EV, the study of this genodermatosis is important to better understand the process of beta-HPV carcinogenesis.
Risk Prediction Scores for Mortality, Cerebrovascular, and Heart Disease Among Chinese People With Type 2 Diabetes
Authors: Quan Jianchao , Pang Deanette , Li Tom K , Choi Cheung Hei , Siu Shing Chung , Tang Simon Y , Wat Nelson M , Woo Jean , Lau Zheng Yi , Tan Kelvin B , Leung Gabriel M
Published: July 2019

Context

Risk scores for cardiovascular and mortality outcomes have not been commonly applied in Chinese populations.

Objective

To develop and externally validate a set of parsimonious risk scores [University of Hong Kong-Singapore (HKU-SG)] to predict the risk of mortality, cerebrovascular disease, and ischemic heart disease among Chinese people with type 2 diabetes and compare HKU-SG risk scores to other existing ones.

Design

Retrospective population-based cohorts drawn from Hong Kong Hospital Authority health records from 2006 to 2014 for development and Singapore Ministry of Health records from 2008 to 2016 for validation. Separate five-year risk scores were derived using Cox proportional hazards models for each outcome.

Setting

Study participants were adults with type 2 diabetes aged 20 years or over, consisting of 678,750 participants from Hong Kong and 386,425 participants from Singapore.

Main Outcome Measures

Performance was evaluated by discrimination (Harrell C-index), and calibration plots comparing predicted against observed risks.

Results

All models had fair external discrimination. Among the risk scores for the diabetes population, ethnic-specific risk scores (HKU-SG and Joint Asia Diabetes Evaluation) performed better than UK Prospective Diabetes Study and Risk Equations for Complications Of type 2 Diabetes models. External validation of the HKU-SG risk scores for mortality, cerebrovascular disease, and ischemic heart disease had corresponding C-indices of 0.778, 0.695, and 0.644. The HKU-SG models appeared well calibrated on visual plots, with predicted risks closely matching observed risks.

Conclusions

The HKU-SG risk scores were developed and externally validated in two large Chinese population-based cohorts. The parsimonious use of clinical predictors compared with previous risk scores could allow wider implementation of risk estimation in diverse Chinese settings.
CHIR-99021 regulates mitochondrial remodelling via β-catenin signalling and miRNA expression during endodermal differentiation
Authors: Ma Yuejiao , Ma Minghui , Sun Jie , Li Weihong , Li Yaqiong , Guo Xinyue , Zhang Haiyan
Published: July 2019

Mitochondrial remodelling is a central feature of stem cell differentiation. However, little is known about the regulatory mechanisms during these processes. Previously, we found that a pharmacological inhibitor of glycogen synthase kinase-3α and -3β, CHIR-99021, initiates human adipose stem cell differentiation into human definitive endodermal progenitor cells (hEPCs), which were directed to differentiate synchronously into hepatocyte-like cells after further treatment with combinations of soluble factors. In this study, we show that CHIR-99021 promotes mitochondrial biogenesis, the expression of PGC-1α (also known as PPARGC1A), TFAM and NRF1 (also known as NFE2L1), oxidative phosphorylation capacities, and the production of reactive oxygen species in hEPCs. Blocking mitochondrial dynamics using siRNA targeting DRP1 (also known as DNM1L) impaired definitive endodermal differentiation. Downregulation of β-catenin (CTNNB1) expression weakened the effect of CHIR-99021 on the induction of mitochondrial remodelling and the expression of transcription factors for mitochondrial biogenesis. Moreover, CHIR-99021 decreased the expression of miR-19b-2-5p, miR-23a-3p, miR-23c, miR-130a-3p and miR-130a-5p in hEPCs, which target transcription factors for mitochondrial biogenesis. These data demonstrate that CHIR-99021 plays a role in mitochondrial structure and function remodelling via activation of the β-catenin signalling pathway and inhibits the expression of miRNAs during definitive endodermal differentiation.

This article has an associated First Person interview with the first author of the paper.
Adaptive hierarchical clustering for hyperspectral image classification: Umbrella Clustering
Authors: Vithana S.S.P. , Ekanayake E.M.M.B. , Rathnayake A.R.M.A.N. , Jayatilaka G.C. , Herath H.M.V.R. , Godaliyadda G.M.R.I. , Ekanayake M.P.B.
Published: July 2019

Hyperspectral Imaging (HSI) utilises the reflectance information of a large number of contiguous spectral bands to solve various problems. However, the relative proximity of spectral signatures among classes can be exploited to generate an adaptive hierarchical structure for HSI classification. This enables a level by level optimisation for clustering at each stage of the hierarchy. The Umbrella Clustering algorithm, introduced in this work, utilises this premise to significantly improve performance compared to non-hierarchical algorithms which attempt to optimise clustering globally. The key feature of the proposed methodology is that, unlike existing hierarchical algorithms which rely on fixed or supervised structures, the proposed method exploits a mechanism in spectral clustering to generate a self-organised hierarchy. The algorithm gradually zooms into the feature space to identify levels of clustering at each stage of the hierarchy. The results further demonstrate that the generated structure tallies with human perception. In addition, an improvement to Linear Discriminant Analysis (LDA) is also introduced to further improve performance. This modification maximises the pairwise class separation in the feature space. The entire algorithm includes this modified LDA step which requires a certain amount of class information in terms of features, at the training phase. The classification algorithm which incorporates all novel concepts was tested on the HSI data set of Pavia University as well the database of Common Sri Lankan Spices and Adulterants in order to assess the versatility of the algorithm.
In vivo MR spectroscopy for breast cancer diagnosis
Authors: Sharma Uma , Jagannathan Naranamangalam Raghunathan
Published: July 2019

Breast cancer is a significant health concern in females, worldwide. In vivo proton (1H) MR spectroscopy (MRS) has evolved as a non-invasive tool for diagnosis and for biochemical characterization of breast cancer. Water-to-fat ratio, fat and water fractions and choline containing compounds (tCho) have been identified as diagnostic biomarkers of malignancy. Detection of tCho in normal breast tissue of volunteers and in lactating females limits the use of tCho as a diagnostic marker. Technological developments like high-field scanners, multi channel coils, pulse sequences with water and fat suppression facilitated easy detection of tCho. Also, quantification of tCho and its cut-off for objective assessment of malignancy have been reported. Meta-analysis of in vivo 1H MRS studies have documented the pooled sensitivities and the specificities in the range of 71–74% and 78–88%, respectively. Inclusion of MRS has been shown to enhance the diagnostic specificity of MRI, however, detection of tCho in small sized lesions (≤1 cm) is challenging even at high magnetic fields. Potential of MRS in monitoring the effect of chemotherapy in breast cancer has also been reported. This review briefly presents the potential clinical role of in vivo 1H MRS in the diagnosis of breast cancer, its current status and future developments.
Comparison of sleep and health behaviors among diabetic patients and non-diabetics in Phitsanulok, Thailand: a cross-sectional study
Authors: Juntarawijit Chudchawal , Juntarawijit Yuwayong
Published: July 2019

Background: Type 2 diabetes mellitus (T2DM) is a global public health problem. To avoid disease complications, diabetic patients have to control their blood glucose and maintain a healthy lifestyle including a healthy diet, weight control, moderate exercise and smoking cessation.

Methods: This study aimed to survey sleep, eating and exercise behaviors of diabetic patients in Bang Rakam district, a rural community in Phitsanulok province, Thailand. The data on sleep and other health behaviors were taken from 1,385 T2DM patients and 1,394 non-T2DM controls, who were aged 30 - 85 years and were free from other chronic diseases. The data were collected using a structured questionnaire.

Results: Compared to the control group, the diabetic group had a significantly higher body mass index (BMI).  However, fewer of them were found to smoke cigarettes and drink alcohol. Most of the participants were ‘morning people’ who slept 7-9 hours per day. It was found that sleep ≥8 hours increased the risk of diabetes among women (OR = 1.27, 95% CI 1.03 - 1.56). The diabetic group reported eating chicken and vegetables more than the control group. They also avoided eating beef and eating more than a cup of rice per meal. However, the T2DM group did fewer physical activities, such as walking, biking or playing sports, during their leisure time.

Conclusions: Compared to the control group, diabetic patients in a rural community of Thailand had healthier sleep, lifestyle and eating behaviors but not healthier exercise behaviors, especially among obese women. Diabetic prevention programs should emphasize and promote weight control and increasing levels of exercise.
Problems accompanist art
Authors: Калицкий Виталий , Kalickiy Vitaliy
Published: July 2019

The monograph reveals the main theoretical, historical and methodological problems of concertmaster's art, and also solves practical problems of concertmaster's performance. For the first time, one publication systematizes various aspects of this problem.
The monograph examines the philosophical and aesthetic orientation of concertmaster art in the context of ensemble performance, clarifies the aspects of professional definitions, and clarifies the fundamental differences between the accompanist and concertmaster.
The study reveals largely unknown pages of the formation of the concertmaster as a separate profession, this process can be traced in the historical and cultural context from ancient times to the present day. The fundamental prerequisites of the formation of concertmaster activity as a special form of music making are analyzed, theoretical and methodical literature, including foreign literature not translated into Russian, psychological aspects of concertmaster activity are studied.
The specificity of concertmaster's work in various performing classes of music schools and in musical theater is studied.
A number of clarifications of the musical text of claviers are given, as well as corrections to incorrectly published musical editions.
The monograph is addressed to concertmasters-practitioners, teachers, students of higher educational institutions, graduate students, assistant trainees studying in the field of "Piano", as well as related specialties.
German
Authors: Акиншина Инна , Akinshina Inna , Мирошниченко Лариса , Miroshnichenko Larisa
Published: July 2019

The textbook for undergraduate students of non-language faculties contains material for mastering the German language at the B1 level as a means
intercultural communication. The main purpose of training is achieved by a comprehensive study of the language through a single thematic focus of oral topics, texts for reading and lexico-grammatical exercises.
Meets the requirements of Federal state educational standards of higher education of the last generation.
The materials can be used both for classroom and for independent work
Transformerless dc Converter for Distributed Solar Power Generation System
Authors: Suryoatmojo Heri
Published: July 2019

There are two types of distributed solar power generation system stand-alone system and grid-connected system. In grid-connected system usually are equiped with additional transformer to transfer the energy from solar power to the grid. However, it has resulted in considerable cost in providing these systems. Therefore in this reserach develops boost transformerless inverter system. The proposed system consists of a boost converter and transformerless inverter. Boost converter is used to increse the dc voltage yield by photovoltaic (PV) and delivered to the grid by mean of  transformerless inverter.In order to maximize the power from PV, the proposed system is also designed with Maximum Power Point Tracking (MPPT) by changing the value of modulation index in the transformerless inverters. From the simulation results show that the system can work effectively in a variety conditions such as light intensity changed and fluctuating in the grid  voltage side.
Implementation of Mamdani Fuzzy Logic Control System on DC Motor Speed Controller
Authors: Freitas Basilio Mendonca , Rameli Mochammad , EAK Rusdhianto
Published: July 2019

Abstract— Drive system is an important role important role in industrial processes, especially in electrical control. Maintaining a DC motor speed is a control system task that requires several method. Generally, set-point is defined as point of demand, and its comparation against process value (current speed) resulted in error. Both error and delta-error are two parameters required to the control system to determine system behavior in correction action. Such system of controller is a useful component to suppress the error signal so that the desired performance can be obtained. This research designs system of DC motor rotation speed control using Arduino Uno microcontroller to meet control specification on laboratory scale, implementing control application and Fuzzy Control System as control system algorithm.Because of its ability to be easily modeled using human intuitive, adaptive, does not require complex mathematical equations, not limited to linear or constant systems, and easily adapted to human input, Mamdani Fuzzy Logic Control System is used.
Ladder Diagram based on State Diagram for Selection and Assembling Part on Dual Conveyor
Authors: Iskandar Eka , Rameli Mochammad , Nicco Nicco
Published: July 2019

Abstract— In industry, conveyor is a means of transportation to move production materials. Conveyor not just move the goods but there are other processes such as counting the number of goods, filling the liquid and so forth because it is equipped with certain sensors and actuators. These processes can be automated by using PLCs as controllers by executing instruction programs in the form of ladder diagrams. The complexity of automation processes in conveyors requires the use of many relays in PLC programming and is difficult to apply to low-specification PLCs. Of course the procurement of PLC with high specifications require a lot of money. In order to overcome these problems it is necessary a method that can minimize the number of relays used so that the program becomes shorter. By using state diagram, the result of construction of ladder diagram is obtained by 32 rung and the program capacity is 3 KB.Keywords—Conveyor, Flow-Table/State Diagram, Ladder Diagram, PLC, Rung.
Design of Motor Current Signature Analyses (MCSA) Based on LabVIEW for Online Detection of Induction Motor Faults
Authors: Asfani Dimas Anton , Soedibyo Soedibyo , Negara I Made Yulistya , Fahmi Daniar , Septiawan Muhammad Eko , Wahyudi Mochammad , Rifma Neisya Islamey
Published: July 2019

Induction motor is the most common used electric motor in industry. Along with its operation, induction motor can savere certain damage which is generally dominated by internal fault, such as s rotor fault, stator fault, and bearing fault. In this paper, the online detection based on motor current signature analyses (MCSA) for such faults was designed using LabVIEW. MCSA was performed to obtain the frequency which indicated the presence of certain damage of induction motor. The experimental result showed that the accuracy of proposed method reached 90 %.
Designing an Optimal Control LQT for Controlling and Guidance of Missile
Authors: AK Rusdhianto Effendie , Prasetyo Muhamad Rafif , Hidayat Zulkifli
Published: July 2019

Missile has to be controlled and follow the commanded guidance in order to make its flight hit the target. Since missile has a nonlinear characteristic and coupled dynamic equation, controlling a missile has become more complex. Linear Quadratic Tracking (LQT) is one of optimal control theory where its objective is to make the output of a system tracks its reference as close as possible while minimize or maximize a desired performance index. In this paper, an autopilot for missile is designed which consists nonlinear state feedback decoupler and LQT controller. Pursuit Guidance is used for the guidance law. A missile-target engagement simulation is created using 2 kinds of target; static target and dynamic target. By using static target, the mean of the closest distance between missile and the target is 0.45 meters and by using dynamic target the mean of the closest distance between missile and the target is 2.562 meters.
Monokristal-monokristal eraldaketak polioxometalatoetan oinarritutako sistemetan: termikoki aktibatutako zenbait adibide
Authors: Fernández-Navarro Leticia , Ruiz-Bilbao Estibaliz , Artetxe Beñat , San Felices Leire , Iturrospe Amaia , Reinoso Santiago
Published: July 2019

Kanpo-estimuluen bitartez aktibatutako fase-trantsizioak, eta haien artean kristal bakun izaera mantentzen duten kasuak, hots monokristal-monokristal (MKMK) eraldaketak, interes handikoak dira; izan ere, gai dira i) ezaugarri berriak dituzten produktuak emateko eta ii) materialaren propietateetan gertatzen diren aldaketak, egitura kristalinoak jasaten dituenekin erlazionatzeko. Polioxometalatoen (POMen) kasuan bezala, egiturei zurruntasuna ematen dieten oinarrizko unitateak erabiltzea bide egokia da prozesuan zehar gerta litekeen kristalinitatearen galera saihesteko. Gaur egun POMetan oinarritutako sistemetan aurki daitezkeen MKMK eraldaketa urrien artean, aipatzekoak dira termikoki aktibatutako adibideak. Lan honetan azken hauek laburbilduko dira eta bereziki gure ikerketa taldean prestatutako konposatuak eta haien erabilerak (katalisia eta gasen xurgapen selektiboa) goraipatuko ditugu.
Perencanaan dan Analisis E-Book Interaktif Materi ASEAN
Authors: Astuti Winda Try , Muslim Much Aziz
Published: July 2019

Upaya meningkatkan mutu pendidikan, pemerintah terus melakukan berbagai macam perbaikan. Kurikulum yang tengah berkembang saat ini adalah kurikulum 2013 yang menuntut kreativitas guru dalam kegiatan pembelajaran. Salah satu faktor yang menyebabkan rendahnya kualitas pembelajaran yaitu belum dimanfaatkannya sumber belajar secara maksimal, baik oleh guru maupun siswa. e-book dapat digunakan sebagai sumber belajar. e-Book merupakan buku dalam format elektronik berisikan informasi yang dapat berwujud teks, gambar, video dan animasi. Penelitian ini bertujuan untuk mengetahui kelayakan e-book interaktif pada materi ASEAN untuk siswa SMA kelas XII. Jenis penelitian ini merupakan penelitian pengembangan e-book interaktif pada materi ASEAN diuji cobakan secara terbatas oleh ahli media. Penelitian pengembangan ini menggunakan metode Multimedia Development Life Cycle (MLDC). Pada tahap Concept menentukan tujuan, sasaran pengguna, dan analisis kebutuhan. Tahap Design membuat storyboard. Tahap Obtaining Content Material mempersiapkan segala bahan dan materi. Tahap Assembly pada e-book interaktif ini menggunakan Adobe Indesign CS6. Tahap Testing melakukan pengujian oleh ahli media. Pada tahap Distribution, e-book interaktif akan dipublikasi CD. Adapun analisis kelayakan e-book interaktif pembelajaran ASEAN dilakukan dengan memberikan lembar evaluasi ke ahli media. Perhitungan analisis kelayakan menggunakan skala likert. Hasil rata-rata analisis kelayakan yang diperoleh ialah 3.7 sehingga e-book interaktif pembelajaran ASEAN layak untuk di distribusika atau dipublikasi.
PERENCANAAN STRATEGIS SI/TI DENGAN METODE ANALISA SWOT DAN BSC UNTUK MENINGKATKAN DAYA SAING DI UNIVERSITAS XYZ
Authors: Retnawati Lestari
Published: July 2019

ABSTRACT XYZ University is an institution that has applied ICT in academic and non academic operations. ICT infrastructure has been built to connect campus A and campus B with wired and wireless based connectivity to support the running of various information systems as a campus conceptual system. The information system owned by XYZ University has not been fully integrated. There are several systems such as Academic Information System, e-learning, financial system, staffing system, e-Slip and various other applications that are not fully integrated yet. The many systems and applications are an asset to XYZ University's institutions, because in its development it has taken quite a bit of time and resources. Therefore, the institution must fully utilize to support the institution in accelerating the achievement of the vision and mission that has been set so that the application of ICT be aligned with the business interests of the institution of Wijaya Kusuma University Surabaya. Then the institution must prepare a strategic information system / information technology (SI / IT). From here the initial idea of the need for a research entitled "Strategic Planning SI / IT With SWOT and BSC Methods At XYZ University. The final result of this study is the portfolio of applications required by XYZ University. Strategic Planning SI / IT With SWOT and BSC Methods At XYZ University aims to provide an overview and recommendation on internal and external business and SI / IT conditions and IT / IT policy management and Information Technology policy at XYZ University. Keywords: Strategic Planning SI / TI, application portfolio, SWOT Analysis, BSC Analysis.
PENERAPAN SISTEM PENGOLAHAN NILAI RAPORT DI MTS AL-GHAZALI MIRIT KEBUMEN BERBASIS WEB
Authors: Sudarmana Landung -
Published: July 2019

Proses pengolahan data yang dilakukan di MTs Al-Ghazali Mirit Kebumen sudah berwujud satu lembar nilai yang pengerjaannya menggunakan microsoft excel, dan wali kelas dalam mengolah nilai raport membutuhkan waktu yang lama, karena harus menunggu nilai-nilai dari guru mata pelajaran. Guru mata pelajaran sering kehilangan data nilai siswa dikarenakan banyaknya berkas nilai berbentuk kertas menjadikan tidak terarsip dengan baik seperti ulangan harian, ulangan tengah semester, ulangan akhir semester, dan disisi lain tidak semua siswa bisa menjaga raport dengan baik, sehingga dikhawatirkan bisa menyebabkan raport hilang, basah terkena air, robek yang mengakibatkan kerusakan pada raport. Penggunaan aplikasi terbatas pada Ms. Excel untuk mengolah data nilai yang dihasilkan tidak terintegrasi dengan baik. Penghitungan nilai akhir dilakukan dengan manual sehingga rawan kesalahan dan jika terdapat perubahan data diperlukan banyak bagian yang diubah. Pengumpulan data dilakukan dengan metode observasi dan wawancara, sedangkan pada tahap analisis dan perancangan menggunakan beberapa tahap yaitu menentukan entitas, mendesain relasi antar tabel, dan membuat form, dan terakhir dilakukan tahap implementasi sistem. Penerapan sebuah sistem pengolahan data nilai raport menjadikan solusi tepat guna membantu pengolahan data nilai raport bagi siswa, guru wali kelas, dan guru mata pelajaran. Penggunaan sistem pengolahan data ini mampu memangkas waktu proses pengolahan data nilai menjadi lebih cepat dibandingkan masih menggunakan proses pengolahan nilai secara manual.Kata Kunci : penerapan sistem, pengolahan data, solusi tepat, nilai raport
APLIKASI TUTORIAL RESEP MASAKAN TRADISIONAL ACEH BERBASIS ANDROID MENGGUNAKAN METODE ANALYTICAL HIERARCHY PROCESS (AHP)
Authors: Dinata Rozzi Kesuma
Published: July 2019

Traditional Aceh cuisine is a dish cooked by the people of Aceh and marinade formulated by the people of Aceh. Based on the results of interviews with the community around the traditional dishes are often cooked every day such as "kuah plik/ patarana, kuah asam keu-eung, kuah masak puteh, kuah lemak/santan, kuah masak mirah, boh manok U, asam sabee, bileh payeh, asam u, dan urap Aceh".  Nowadays according to the advanced application can help the young mothers who from not able to cook become skilful cooking Aceh cuisine, one of them is from the application of traditional recipe of Aceh-based recipe android so that the young mothers can be assisted in the process of way cooking Aceh cuisine. In implementing the AHP method, the authors use the method on the portion of the cuisine divided into 3 (three) portion division of which the three portion, the seven portions and the 12 portions. We show that results in rankings of the most desirable of the 12th share with the highest ranking value of the calculation are 0.37.
APLIKASI JARINGAN SYARAF TIRUAN DALAM PENGENALAN POLA HURUF PEGON JAWA
Authors: Surrisyad Hari , Yazid Ahmad Subhan
Published: July 2019

Artificial Neural Network (ANN) Technology) can help humans in processing data into information with design resembling the performance of the human brain. ANN adopts 5 aspects of human capability: Memorization, Generalization, Efficiency, Accuracy, and Tolerance in its application. ANN proves to be effective in pattern recognition. Researchers developed an application implementing ANN to recognize Java Pegon Letter pattern. The research uses 160 image data, divided into 100 training data (consisting of 5 normal images for each character) and 60 test data (consisting of 1 normal data, 1 data is not complete/corrupt, and 1 data with noise) for each character. The data obtained from the processed captures, so all of data have the same dimensions and size: 100x100 pixels. All data is processed through preprocessing and extraction stages. Furthermore, the data result is used in training stage to recognize the pattern of Java Pegon by applying the Learning Vector Quantization method. The application can recognize Java pegon pattern very well. The application can recognize 100% of training data and test data. This application also has the ability to recognize abnormal data very well, such as data with noise or corrupted data.
Analisis Kedudukan I’rab Kalimah Bahasa Arab Pada Kitab Al - Imrithi Menggunakan Algoritma Breadth First Search (BFS)
Authors: Muawanah Risalatul , Rifa'i Aulia Faqih
Published: July 2019

Alquran and hadist are the source of life guidance for muslims, and books of scolars as the proponents. The structure of contents use Arabic language, so studying of Arabic language recommended to all of muslims in islam. Difficutly of understanding structure of Arabic languageis in analyzing Irab. Errors in determining harakat offen occur.This research was conducted tobuild the system in determining Irob position consisting of from, category, Irob and position ofkalimah by implemting Artificial Intelligence especially with Breadth First Search.Refer to theresult of the test that research do with so samples of simple sentence, about 90% this systemis able run well. The result test questionnaire , useful from 35 respondents showed 41.0% ofthem strongly agreed, 44.5% agreed, and 14.3% choosen neutral.                                                                                                     Keywords : Al Imrithi, Breadth First Search, Arabic Language, Irab Analysis
Rekonstruksi Pemikiran Kartini tentang Keagamaan untuk Memperkuat Integrasi Nasional
Authors: Muchoiyyaroh Lilis
Published: July 2019

Kartini's complex thinking about her nation was the result of observations and experiences that she experienced empirically. But Kartini's ideas about religion were explicitly influenced by the surrounding environment, both European and indigenous people themselves. This study focuses on the reconstruction of Kartini's thinking in the field of religion and the social background of the emergence of this thought. Therefore, this study uses historical methods with a social history approach to identify Kartini's ideas in the religious field. The reconstruction of her ideas as one of the national integration efforts that cannot be separated from the influence of the religiosity and social background of the people around her. Kartini's thinking about religion was critical, open, and pluralistic, which was concerned with the division of the nation due to religious differences.
Terminal Kalibaru sebagai Solusi Mengatasi Kemacetan Bongkar Muat Peti Kemas di Pelabuhan Tanjung Priok Jakarta, 2011-2016
Authors: Padliansyah P. , Widodo Sutejo K. , Susilowati Endang
Published: July 2019

This study argues that container loading and unloading congestion at Tanjung Priok Port is caused by long dwelling time due to the limited capacity of existing container terminals. Therefore, the Kalibaru Terminal was built to overcome this problem. The research objective is to look at the planning, construction, and operation of the Kalibaru Terminal. This study uses historical methods consisting of heuristics, source criticism, interpretation, and historiography. The results of this study indicate that the construction of the Kalibaru Terminal is a superior project of government and private cooperation so that it must go through an international tender. The development of Kalibaru Terminal aims to increase productivity and accelerate economic growth. The existence of the Kalibaru Terminal also caused the flow of goods to run smoothly and decrease in dwelling time from eight to three days.
Identitas Budaya Masyarakat Kota: Teater Tradisi di Kota Surabaya Pada Awal Abad XX
Authors: Samidi S.
Published: July 2019

This study examines why does Ludruk represent the cultural identity of the people of Surabaya? How does society appreciate the traditional theater, especially in Ludruk in their daily practice? The purpose of this article explains the historical reality of Ludruk art that serves as entertainment and cultural identity. This article using the historical method by relying on historical sources. The result shows that theater traditions that existed and famous in Surabaya at the beginning of the 20th century were Comedy Stambul, Wayang Wong, and Ludruk, then appeared Ketoprak in the late 1930s. The appearance of this theater has been adapted to the tastes of the support community. Comedy Stambul is a theater that originated in India, then spread to Southeast Asia. Comedy Stambul is considered as a hybrid art because it comes from a blend of local cultural elements, while Wayang Wong, Ludruk, and Ketoprak an original art derived from customs and local values. Theater that represents the cultural identity of the people of Surabaya is Ludruk.
An extension theorem for non-compact split embedded Riemannian symmetric spaces and an application to their universal property
Authors: Grüning Julius , Köhl Ralf
Published: July 2019

By [5] it is known that a geodesic γ in an abstract reflection space X (in the sense of Loos, without any assumption of differential structure) canonically admits an action of a 1-parameter subgroup of the group of transvections of X. In this article, we modify these arguments in order to prove an analog of this result stating that, if X contains an embedded hyperbolic plane 𝓗 ⊂ X, then this yields a canonical action of a subgroup of the transvection group of X isomorphic to a perfect central extension of PSL2(ℝ). This result can be further extended to arbitrary Riemannian symmetric spaces of non-compact split type Y lying in X and can be used to prove that a Riemannian symmetric space and, more generally, the Kac–Moody symmetric space G/K for an algebraically simply connected two-spherical split Kac–Moody group G, as defined in [5], satisfies a universal property similar to the universal property that the group G satisfies itself.
Does Television Kill Your Sex Life? Microeconometric Evidence from 80 Countries
Authors: Lucas Adrienne M. , Wilson Nicholas L.
Published: July 2019

The canonical consumer demand model predicts that as the price of a substitute decreases, quantity demanded for a good decrease. In the case of demand for sexual activity and availability of alternative leisure activities, popular culture expresses this prediction as “television kills your sex life.” This paper examines the association between television ownership and coital frequency using data from nearly 4 million individuals in national household surveys in 80 countries from 5 continents. The results suggest that while television may not kill your sex life, it is associated with some sex life morbidity. Under our most conservative estimate, we find that television ownership is associated with approximately a 6 % reduction in the likelihood of having had sex in the past week, consistent with a small degree of substitutability between television viewing and sexual activity. Household wealth and reproductive health knowledge do not appear to be driving this association.
Updates on Section Pseudo-opuntia of Halimeda: phylogenetic analyses of H. soniae sp. nov. (Bryopsidales, Chlorophyta) along the Brazilian coast
Authors: Ximenes Caroline Feijão , de Oliveira-Carvalho Maria de Fátima , Bandeira-Pedrosa Maria Elizabeth , Cassano Valéria
Published: July 2019

Halimeda is a genus of green seaweed showing high morphological plasticity. Studies using molecular markers for species delimitations and phylogenetics have revealed cryptic diversity and new species throughout the world. Seven species of Halimeda are currently recognized in Brazil. The present study describes the new species Halimeda soniae Ximenes, Oliveira-Carvalho, M. E. Bandeira-Pedrosa et Cassano sp. nov. to accommodate the taxon previously identified as Halimeda aff. gracilis for Brazil. Samples of H. soniae were collected in Espírito Santo State (southeastern Brazil), and plastid gene sequences of tufA and rbcL were obtained. Phylogenetic analyses showed that H. soniae belongs to Section Pseudo-opuntia, together with Halimeda gracilis and Halimeda lacrimosa; the three species have overlapping morpho-anatomical features. Phylogenetic analyses suggest that H. gracilis is restricted to the Indo-Pacific Ocean, whereas the other two species appear to be restricted to the Atlantic. Additional research on Caribbean specimens will be necessary to resolve the taxonomic position of the taxa named as H. lacrimosa and H. gracilis in that region. Based on our results, H. gracilis does not occur in the Brazilian marine flora.
Unaltered morphemes as phonological triggers and targets in Rutooro
Authors: Bickmore Lee S.
Published: July 2019

Rutooro, a Bantu language spoken in western Uganda, exhibits two processes common to Bantu languages: Mid Vowel Harmony (MVH), by which a high vowel is lowered to mid if it follows a mid root vowel, and Consonant Mutation (CM), by which a high front vowel of certain morphemes trigger a change in the immediately preceding consonant. In forms where both rules could potentially apply, CM applies, but MVH does not, even though its structural description is met. Ultimately, it is shown that MVH is blocked when an alveolar fricative intervenes between the trigger and the target. The most anomalous forms are those that contain the short causative /-i/ and the Perfective suffix /-ir/. In some forms CM would be expected to apply, but does not, and in other forms MVH is expected to be blocked, but is not. The key to the analysis lies in the fact that CM is not a purely phonological process, but rather is only triggered by a small set of specific morphemes. The surface anomalies in the perfect forms can all be accounted for if one formalizes the relevant processes as only being triggered (or blocked) by unaltered [-ir].
Assessment, Prediction and Mapping of Noise Levels in Vellore City, India
Authors: Manojkumar N. , Basha Khadar , Srimuruganandam B.
Published: July 2019

Present study focuses on measurement, prediction and mapping of noise levels in important places of Vellore city located in Tamil Nadu state, India. Weekday and weekend noise levels at six locations (S1 to S6) are recorded during morning, afternoon and evening times. Sampling locations includes educational (S1), commercial (S2 and S4), tourist and recreational (S3), and mixed (S5 and S6) zones. Assessment in Vellore city showed maximum Leq level in S4 and S5 and lowest is recorded in S3 throughout the study. Highest Leq levels are recorded in evening (57.52–78.41 dB(A)) and afternoon (58.76–76.39 dB(A)) time during weekday and weekend, respectively. Along with Leq, noise descriptors are also included and discussed in this study. Weekend has higher mean value of TNI thanWeekday. CoRTN model is employed to predict the L10 values. Results showed good performance of model with marginal difference between measured and predicted L10 levels. Further noise maps are created separately for weekday and weekend using ArcGIS software. Noise maps showed alarming noise levels near sampling sites and it is suggested to take immediate preventive measures using barriers or by providing alternative traffic routes.
Integrated teaching in medical education in India: Scope, current status and opportunities
Authors: Shrivastava Saurabh RamBihariLal , Shrivastava Prateek Saurabh
Published: July 2019

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The relationship between alexithymia and shyness in nursing students with mediating roles of loneliness and social identity
Authors: Sangani Alireza , Jangi Paria
Published: July 2019

Background: Shyness is a main cause of poor results in the educational environment. The present study aimed at studying relationship between alexithymia (the inability to recognize or describe one’s own emotions) and shyness in nursing students, with mediating roles of loneliness and social identity. Methods: This descriptive-correlational study was based on structural equation modeling, specific regression equations, and a statistical population of 658 nursing students at Ahvaz University of Medical Sciences in 2018. A sample of 331 students was selected. To collect the data, Toronto’s Alexithymia Scale, Russell, Peplau and Cutrona’s Loneliness Scale, Safarinia’s Social Identity Questionnaire and Briggs, Cheek and Buss’ Shyness Scale were used. Results: The findings from regression analysis showed that there was a direct effect between alexithymia and shyness and an indirect effect between alexithymia and shyness with mediating factors of loneliness and social identity (P<0.01). In total, alexithymia, feelings of loneliness, and perception of social identity had a predictive power of 0.51% of shyness. Conclusion: The results of this study show the effect of alexithymia and the role of moderating influences on feelings of loneliness and social identity perceptions and shyness among nursing students, which can provide useful practical applications to advisers and trainers in order to improve the psychological state of nursing students.
Influence of calculation criteria on the values of low-flow recession constants in a non-homogenous catchment in Slovenia
Authors: Sapač Klaudija , Rusjan Simon , Šraj Mojca
Published: July 2019

In this paper we analyse the influence of three different calculation criteria on the values of low-flow recession constants, namely the influence of the calculation method, recession curve segment length (4, 5, 6, or 7 days) and of the selected period (whole period, monthly, seasonally) for the calculation of the initial discharge, which determines the threshold on the falling limb of the hydrograph for the recession analysis. The analysis is based on daily discharge data of 11 gauging stations in the hydrogeologically non-homogenous Ljubljanica River catchment. For each of the stations, we calculated 24 values of recession constants using a different combination of criteria. Based on these values we determined the influence of each criterion on the final result using statistical tests and graphical approaches. Analysis showed that the recession constants calculated using various methods are statistically significantly different for all gauging stations. The recession constants obtained using the individual recession segment method (IRS) are on average 3.1 days higher than those calculated using the master recession curve method (MRC). The influence of the other two criteria, namely the length of the segment and the period for calculating the initial discharge, is not so obvious, since it is most likely conditioned by catchments’ characteristics influencing the time dynamics of the runoff.
PTPRM, a candidate tumor suppressor gene in small intestinal neuroendocrine tumors
Authors: Barazeghi Elham , Hellman Per , Westin Gunnar , Stålberg Peter
Published: July 2019

Small intestinal neuroendocrine tumors (SI-NETs) are small, slow growing neoplasms with loss of one copy of chromosome 18 as a common event. Frequently mutated genes on chromosome 18 or elsewhere have not been found so far. The aim of this study was to investigate a possible tumor suppressor role of the transmembrane receptor type tyrosine phosphatase PTPµ (PTPRM at 18p11) in SI-NETs. Immunohistochemistry, quantitative RT-PCR, colony formation assay and quantitative CpG methylation analysis by pyrosequencing were performed. Undetectable/very low levels of PTPRM or aberrant pattern of immunostaining, with both negative and positive areas, were detected in the majority of tumors (33/40), and a significantly reduced mRNA expression in metastases compared to primary tumors was observed. Both the DNA methylation inhibitor 5-aza-2′-deoxycytidine and the S-adenosylhomocysteine hydrolase inhibitor 3-deazaneplanocin A (DZNep) induced PTPRM expression in CNDT2.5 and KRJ-I SI-NET cells. CpG methylation of upstream regulatory regions, the promoter region and the exon 1/intron 1 boundary was detected by pyrosequencing analysis of the two cell lines and not in the analyzed SI-NETs. Overexpression of PTPRM in the SI-NET cell lines reduced cell growth and cell proliferation and induced apoptosis. The tyrosine phosphatase activity of PTPRM was not involved in cell growth inhibition. The results support a role for PTPRM as a dysregulated candidate tumor suppressor gene in SI-NETs and further analyses of the involved mechanisms are warranted.