bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effect of Workload, Work Motivation and Work Environment on Employee Job Satisfaction
Authors: Mandjar Tania Laurencia , Turangan Joyce A.
Published: July 2023

Employee job satisfaction is the individual's level of satisfaction for a role or job in an organization. Researchers have pointed out that employees with higher satisfaction tend to be more loyal and productive. This study aimed to analyze the effects of workload, work motivation, and work environment on employee job satisfaction. The research sample was 110 employees of PT. Andalan Ekspor Indonesia using the non-probability sampling technique. The research method uses SmartPLS and data for conducting this research was obtained through filling out questionnaires through Google Form. The results showed that there is a negative influence of workload on the job satisfaction of employees of PT. Andalan Ekspor Indonesia and a positive influence of work motivation and work environment on the job satisfaction of employees of PT. Andalan Ekspor Indonesia.
Modeling of Sustainability Knowledge: Under Perception on Entrepreneurship Students
Authors: Nuringsih Kartika , Edalmen Edalmen , N. Nuryasman M.
Published: July 2023

As aligning with sustainability issues, the study generates about modeling of sustainability knowledge with a factor analysis approach based on sustainable development goals (SDGs). The population involves entrepreneurial students with processing techniques using factor analysis using SPSS (n=150). The result of testing the Principal Component Analysis method provides the largest contribution of 57.817% with forming four components grouped in Component 1. However, the result is not logical so a rotation process is carried out with several methods including Equamax. After rotating, it produces four components, namely: Component 1 includes SDGs_3, SDGs_4, SDGs_7, SDGs_13, SDGs_17 with the name domain of social equity. Component 2 includes SDGs_9, SDGs_10, SDGs_11, SDGs_14, SDGs_15, SDGs_16 with domain of environmental sustainability. Component 3 includes SDGs_5, SDGs_6, SDGs_12 with the name domain of cultural responsibility. Lastly, Component 4 includes SDGs_1, SDGs_2, SDGs_8 with the domain of economic viability. Based on these results is concluded that the sustainable knowledge construct consists of four dimensions, such as social equity, environmental sustainability, cultural responsibility, and economic viability which are aligned with the pillars of sustainable development. It may be considered to enhance sustainability entrepreneurial learning at the university level.
Dividend Policy: Examining The Effect of Probability, Leverage, Firm Size, and Growth & Investment Opportunity
Authors: Salim Evans , Widoatmojo Sawidji
Published: July 2023

This study aims to determine the effect of profitability, leverage, company size, and growth & investment opportunities on dividend policies from all non-financial companies listed on Indonesian Stock Exchange for the 2018-2020 period. This study generated 288 data from the 96 companies observed which met the purposive sampling criteria. Panel data regression, processed by EViews 10 is used as an analytical method for testing the hypotheses. To determine the best data estimation model, we utilized Chow Test and Hausman Test, which results pointed out that Fixed Effect Model is the most suitable for this study. Correlations and Glejser Test are also conducted beforehand, to ensure that both Multicollinearity and Heteroscedasticity are not present in this model. Research results found that profitability has a positive significant effect on dividend policy, leverage has a positive but insignificant effect on dividend policy, company size has a positive but insignificant effect on dividend policy, and lastly growth & investment opportunities has a negative but insignificant effect on dividend policy.
Analysis of Digital Bank Services in Indonesia Based on Consumer Perception
Authors: Natsir Khairina , Arifin Agus Zainul , Sadhewa Claudius Barly , Aprilia Della , Dharsono Selvi
Published: July 2023

This study aims to find out that Financial Performance in a company that provides Digital Bank services can be influenced by consumer perceptions represented through the variables of Customer Experience, Customer Satisfaction and Customer Loyalty. The data were collected using a survey aimed at users of Digital Bank services in Indonesia which was then tested statistically by analysis of the Outer Model and the Inner Model using Partial Least Square (PLS). Unlike other studies, this study used NPS (Net Promoter Score) as an indicator of Financial Performance Customer Experience, Customer Satisfaction and Customer Loyalty.  The results of the study showed that Customer Experience, Customer Loyalty and Customer Satisfaction had a positive effect on Financial Performance, Customer Experience had a positive effect on Customer Loyalty and Customer Satisfaction. This study also found that Customer Loyalty and Customer Satisfaction mediate the influence of Financial Experience on Financial Performance.
The Effect of Audit Committee Meetings, Profitability, and Foreign Ownership on Intellectual Capital
Authors: Bangun Nurainun , Ngadiman Ngadiman , Natsir Khairina
Published: July 2023

This study aims to obtain empirical evidence regarding the factors that affect intellectual capital in manufacturing companies listed on the Indonesia Stock Exchange during 2019-2021. The number of companies as the research sample was 34 manufacturing companies which were selected through purposive sampling technique with predetermined criteria. Intellectual capital is measured by Value Added Intellectual Coefficient (VAIC) taking into account VACA, VAHU, STVA. Panel data were processed using Eviews 12.0. Classical assumption testing includes multicollinearity test and heteroscedasticity test. Model selection is done by testing Chow, Hausman and Lagrange Multiplier. While the hypothesis test using the t test and the coefficient of determination test. The results of the analysis show that the audit committee frequency of meetings has a negative and insignificant effect on intellectual capital, Profitability as proxied by Return on Assets (ROA) has a positive and significant effect on intellectual capital, and Foreign ownership has a positive and significant effect on intellectual capital,
The Influence of Financial Knowledge, Financial Literacy, and Financial Technology on Financial Management Behavior Among Young Adults
Authors: Jennifer Jennifer , Widoatmodjo Sawidji
Published: July 2023

The purpose of this research is to analyze the effect of financial knowledge, financial literacy, and financial technology on financial management behavior of young adults in the city of Jakarta. The sample selection technique in this study was purposive sampling. The sample used in this study is 150 respondents, obtained through the distribution of online questionnaires. This research uses Smart PLS software version 3.2.9 to process the data. The result of the analysis shows that financial knowledge, financial literacy, and financial technology have a significant and positive effect on financial management behavior on young adults in the city of Jakarta.
Financial Performance and Some Factors that Influence: An Empirical Study on Manufacturing Company
Authors: Setiawan Fedra Valeria , Ekadjaja Agustin
Published: July 2023

Financial performance is a complex matter and it cannot be separated from the efficiency of the company's activities. Regarding to the statement, the purpose of this study is to find out empirically how the influence of leverage, firm size, firm age, and cash flow on financial performance of manufacturing companies in the non-cyclical consumption sector period 2017-2020. The sample collection method used is judgement sampling with 31 manufacturing companies and 124 total observations of manufacturing companies data. This research uses EViews version 12.0 as a data processing software. This study shows results that cash flow have a positive effect on financial performance, but leverage, firm size, and firm age have no effect on financial performance.
Intellectual Capital, Capital Structure, Firm Size, Firm Age and Financial Performance
Authors: Rundjan Esther Priscilla , Susanti Merry
Published: July 2023

This study aims to find out how the role of the components of intellectual capital and capital structure on financial performance in financial sector companies listed on the Indonesia Stock Exchange during 2018-2020. Samples were selected by purposive sampling method and valid data were 59 companies. The data processing technique uses multiple regression analysis assisted by the EViews 12 SV program and Microsoft Excel. The results of this study show that the three components of intellectual capital, namely structure capital efficiency, human capital efficiency and capital employed efficiency as well as capital structure have a significant influence on the company's financial performance. The implication of this study is that it is necessary to maintain the company's attention to employees, the values that can make the company unique, as well as company funding that will improve the company's financial performance that will provide a good signal for investors.
Factors that Affect Continuance Usage Intention of E-Wallet Users in Jakarta
Authors: Ruslim Tommy Setiawan , Alexandra Kenny
Published: July 2023

The growth of technology produces many innovative technologies that make people's lives easier. Competition between technology companies is getting fiercer, they are competing to be the number one in their industry. One of the innovative technologies is the e-wallet. The pandemic and social distancing, make contactless technology grow faster. One of the e-wallets is Sakuku by BCA. When the e-wallet industry is increasing, conversely, active Sakuku users are decreasing. This can occur due to several factors such as confirmation, perceived usefulness, perceived ease of use, and satisfaction. This study examines the effect of confirmation, perceived usefulness, perceived ease of use, and satisfaction on the continuance usage intention of Sakuku users in Jakarta. This study uses PLS-SEM as data analysis technique using data from 232 respondents who have filled out online questionnaires via google form. The results of data analysis show that perceived usefulness and satisfaction can directly affect continuance usage intention. Perceived ease of use cannot affect directly but must go through satisfaction. In addition, confirmation, perceived usefulness, and perceived ease of use can affect satisfaction.
The Effect of Work Environment and Compensation on Employee Work Satisfaction at Medical Appliance Company
Authors: Sinuraya Aprilia Riahta Millenia , Ekawati Sanny
Published: July 2023

The purpose of this study was to examine the effect of work environment and compensation towards employees work satisfaction at Medical Appliance Company. This study was causal research using quantitative method. The sampling method used purposive sampling technique based on certain criteria. This study had a sample size of 57 respondents. The data analysis used outer and inner model test in SmartPLS software version 3.3. The findings of this study showed that the work environment and compensation had a positive and significant effect on employee work satisfaction at Medical Appliance Company. This study can be used as a reference for Human Resource Department to make policy and decision that have an impact on increasing employee job satisfaction.
The Effect of Entrepreneurship Orientation and Innovation on Sustainable Business Growth SME’s Rice Box in West Jakarta
Authors: Clarissa Stephanie , Selamat Frangky , Lim Andriew
Published: July 2023

This study aims to examine whether 1) Entrepreneurial orientation has a positive relationship to sustainable business growth. 2) Innovation has a positive relationship to sustainable business growth. The research design used is quantitatie research and uses a questionnaire for data collection. The number of samples obtained by the non-probability sampling method and purposive sampling technique were collected as many as 120 rice box SME’s owner West Jakarta which are then used in this study. Data were analysed using quantitative methods and distributing questionnaire questions with google form then in taking data using a Likert scale and using data analysis techniques Structural Equation Modelling - Partial Least Square assisted by Smart PLS version 3.0 software. The level of significance was measured through a bootstrapping procedure. The results show that indeed entrepreneurial orientation has a significant positive relationship to sustainable business growth, Innovation has a significant positive relationship to sustainable business growth.
The Influence of Attitude Toward Money, Locus of Control, Financial Self-Efficacy and Self-Control on Financial Management Behavior
Authors: Chandra Welly , Pamungkas Ary Satria
Published: July 2023

The aim of this study was to determine the role of Attitude toward Money, Locus of Control, Financial Self-Efficacy and Self-Control in explaining Financial Management Behavior among workers that use E-commerce and live in Jakarta. The samples used in this study are workers that use E-commerce and live in Jakarta. This study collected 208 samples who are workers that use E-commerce and live in Jakarta. The respondents selected by using convenience sampling method. This research used Partial Least Square-Structural Equation Modeling (PLS-SEM) to analyze data. The result of this study indicated that Attitude toward Money, Locus of Control, Financial Self-Efficacy and Self-Control has positive influence on explaining Financial Management Behavior.
What Can Financial Technology Learn from Syariah Finance on Ecosystem: Collaboration
Authors: Johan Suwinto
Published: July 2023

Shariah financing is financing based on Islamic values. Shariah financing must meet several requirements. The shariah financing process must follow the shariah process from start to finish. Financial technology companies also need an ecosystem to grow. Financial technology companies can emulate shariah financing. This study aims to discuss the shariah financing ecosystem that can be studied by financial technology. This research uses qualitative research methods. This study conducted a literature study on shariah financing and financial technology financing. The research concludes that financial technology financing can work with financial technology companies to develop shariah financing. Shariah financing and financial technology financing require an ecosystem. Cooperation of shariah financing and financial technology is one of the best solutions for the development of both financings.
Factors Affecting Stock Prices with EPS as Moderating Variable Among Manufacturing Companies
Authors: Nathania Madeline , Wijaya Henryanto
Published: July 2023

The goal of this study is to look at the impact of liquidity, profitability, and also solvency towards the stock prices in manufacturing businesses issued on the Indonesia Stock Exchange (IDX) starting from 2018 to 2020, utilizing Earnings per Share (EPS) as a moderating variable. In order to gain samples for the research, we used descriptive quantitative with purposive sampling technique. The data collected contains 210 samples, including 70 manufacturing enterprises that were listed on the IDX from 2018 to 2020. Moderated Regression Analysis (MRA) is used in conjunction with EViews 10 software to process the data. MRA is used to model the case because in MRA, the regression equation contains interaction element between variables to know if the effect of a moderating variable is getting stronger or weaker. The findings reveal that both liquidity and profitability brings a advantageous and large impact towards stock prices, whereas solvency and EPS have a negative and minor impact, and that EPS can mitigate the impact of profitability, liquidity, and solvency in relation to stock prices. This study's implications include the need to enhance a company's performance and financial situation so that its financial statements are sound and stock prices rise, which is, of course, a good sign for investors.
APLIKASI PENCARIAN PROPERTI DI JAKARTA DENGAN METODE ANALYTIC NETWORK PROCESS DAN TOPSIS
Authors: Munenori M.E. Yagyu , Christanti Mawardi Viny , Jaya Perdana Novario
Published: July 2023

There have been several buying and selling applications that are intended to help bring together buyers, sellers, or agents in finding the house criteria needed. But there are still conditions where buyers find it difficult to find the house or property of their dreams. At the same time sellers are also difficult to find the right buyer. For that we need an application that can realize a search application with property recommendation features that can be used to find the best unit that suits their wishes. The methods used are the Analytic Network Process and TOPSIS methods. The ANP method is used because of the consideration of the interrelationships between elements at different levels. TOPSIS method is also used to be able to display more accurate results in terms of ranking. From the recommendation test, 90% of the 10 tests were obtained and the percentage result was 94.1% from 17 respondent tests. Based on these tests, it is known that the error occurred because the data was not found. The absence of property data in accordance with the Criteria can be caused by filling out invalid criteria and can also be caused by a lack of variation in property data.
«КУЛЬТУРНИЙ НАЦІОНАЛІЗМ» ІВАНА ФРАНКА І ГАЛИЦЬКЕ МОСКВОФІЛЬСТВО
Authors: МИКИТЮК Володимир
Published: July 2023

Наукове осмислення проблематики націоналізму все ще продуктивне, а історичний досвід системного протистояння москвофільській ідеології в Галичині І. Франка є сьогодні особливо актуальним. Націоналістичну парадигму українського вченого і його світогляд з 2-ї пол. 1880-х років визначали діалектичні принципи розвитку та взаємозв’язку соціального і національного із щораз вагомішим переважанням саме національного. На основі класичних і найновіших схем періодизації діяльності Франка у статті доведено, що визначальною якістю для нього був універсалізм етнокультурної та національної проблематики з приматом національної ідеї української державності замість соціалістичної доктрини. Стверджено, що Франко – це приклад українського національного інтелектуала з виразною європейською ідентичністю, а його  спадщина може активно впливати на формування світоглядної позиції сучасної України через приналежність до європейської історії, носія окцидентальної ментальності. Світоглядну позицію ученого проаналізовано як учасника та творця українського культурного націоналізму на противагу до націоналізму політичного, а системний аналіз і критику москвофільського руху спроектовано на реалії ХХІ ст. Важливим для сучасного європейського культурного і політичного ландшафту є судження І. Франка про різновиди російського пропагандистського наступу (москвофільство соціальне, мовнокультурне, політичне) та аргументовані приклади цілеспрямованої інформаційної війни. Зроблено висновки, що тільки тривалий і комплексний процес освіти та культурного і політичного виховання нації може дати відпірність, оскільки робить суспільство не тільки вільним, але й відповідальним, кшталтує культуру діалогу і творить національну перспективу. У статті також проаналізовано приклади «оплачуваного» державного шпіонського та «сікофанського» москвофільства на прикладах Франкових буквальних епітетів-характеристик та образів-метафор для маркування москвофільського руху, уточнено фактичну інформацію та прокоментовано алюзії у розвідках Івана Франка до кримінального процесу Юзефа Гендігера. Доведено, що І. Франко був переконаним «західним» ліберальним культурним націоналістом, українським інтелектуалом з окцидентальною ідентичністю, що відстоював цивілізовані європейські морально-етичні правила міжнаціонального буття, дотримання елементарних норм політичної боротьби, чого не передбачала ні тодішня, ні теперішня московська політика, яка змагає до гомогенізації російського абсолютизму.
ASPECTOS SOCIAIS E CLÍNICOS DE CRIANÇAS COM TRANSTORNO DO ESPECTRO AUTISTA DE UM MOVIMENTO SOCIAL DE UM MUNICÍPIO LITORÂNEO DA REGIÃO DO NORTE FLUMINENSE
Authors: Da Costa Ana Carolina Souza , Alves Beatriz Graziele Thomaz , Estebanez Luanna Faria , Lopes Nathalia Ribeiro , Brandão Mariana Folly , Paes Carina de Aquino , Monteiro Luana Silva , Capelli Jane de Carlos Santana
Published: July 2023

Objetivo: Identificar os aspectos sociais e clínicos de crianças com transtorno do espectro autista (TEA) de um movimento social de Macaé, Rio de Janeiro, Brasil. Métodos: Estudo do tipo exploratório, quantitativo, de corte seccional, de base primária, desenvolvido no período entre março e junho de 2020, com crianças (2 a 9 anos 11 meses e 29 dias) com TEA (n=97) e suas respectivas mães de um movimento social do município de Macaé, Rio de Janeiro. A coleta de dados foi realizada com a aplicação de um questionário virtual semiestruturado, elaborado para o estudo, contendo os dados socioeconômicos, demográficos, características clínicas e aspectos marcantes da criança respondido pelos pais ou responsáveis dela. O estudo foi aprovado pelo Comité de Ética em Pesquisa. Resultados: O estudo revelou crianças com idade média±DP de 5,4±1,8 anos, a maioria do sexo masculino (81,5%); sem alfabetização (75,0%); pardas (48,0%) e brancas (44,0%); sem doenças associadas (72,8%) e sem doenças adquiridas (75,0%); em uso de medicamentos (60,9%), dos quais 38,0% eram antipsicóticos atípicos. Verificou-se que 72,8% apresentavam déficits na comunicação e interação social; 71,7% dificuldade ou ausência de fala; 68,5% atividades repetitivas e comportamentos estereotipados; 44,6% redução do contato visual, e 31,5% restrição em mostrar, pegar ou utilizar objetos. Conclusão: A maior parte das crianças analisadas não apresentou doenças associadas, doenças adquiridas e seletividade alimentar; usa medicamentos, principalmente, a risperidona; possui déficits na comunicação e interação social, dificuldade ou ausência de fala, atividades repetitivas e comportamentos estereotipados, como descritos na literatura.
Multi-Degree-of-Freedom Active Isolation Platform for Microvibrations
Authors: Lafarga Vicente , Jamshidi Rasa , Rodrigues Gonçalo , Seiler René , Collette Christophe
Published: July 2023

Reaction wheels are widely used in the attitude control of spacecraft due to their capability of applying control torques, greatly reducing the propellant requirements and limiting its use to reaction wheel desaturation. However, the presence of unavoidable mechanical imperfections results in significant mechanical disturbances, being applied to the spacecraft, which can severely impact the operation of sensitive payloads. These microvibrations are broadband in nature, and therefore the effective mitigation of their effects requires a high isolation factor throughout a wide frequency range. This paper presents the development and experimental verification of a six-degree-of-freedom active isolation platform for a reaction wheel, integrating a soft suspension and active control using self-sensing actuators. A reduction in the transmitted forces of 65 dB at 270 Hz was experimentally demonstrated, while exhibiting negligible amplifications by its suspension resonance, which constitute very attractive performances.
Design of an Active Balancing System for Rotating Orbital Devices
Authors: Meraglia Salvatore , Invernizzi Davide , Lovera Marco , Mohtar Tharek , Bursi Alessandro
Published: July 2023

This paper presents the design of an active balancing system for rotating orbital devices, motivated by recent space applications for spacecraft endowed with rotating payloads. The main motivation behind this work is the Copernicus Imaging Microwave Radiometry mission, which will feature a large rotating microwave radiometer to provide observations of sea-surface temperature, sea-ice concentration, and sea-surface salinity. Due to the presence of highly uncertain inertial asymmetries in the rotating device, potentially large internal forces and torques can appear at interface between the spacecraft and the rotor, which can cause a significant degradation of the system performance and can even affect its stability. To counteract such unbalance effects, an active balancing system made of a suitable set of actuated movable masses and sensors is developed in this work. Exploiting the time-periodic nature of the underlying dynamics, a harmonic controller has been designed to command the positions of the actuated masses in such a way that the effects of rotor unbalance are significantly reduced. After extensive numerical simulations, accounting for both parametric uncertainties and exogenous disturbances in the model, a dedicated breadboard has been developed and experimental validation of the control law has been carried out.
Numerical Investigations of Nonlinearly Generated Disturbance Waves in High-Speed Boundary Layers
Authors: Hader Christoph , Fasel Hermann F.
Published: July 2023

In several experimental investigations of hypersonic boundary-layer transition, higher harmonics of the linearly unstable second mode waves as well as low-frequency waves, which are not related to first mode waves, have been observed. It has been conjectured that the higher harmonics are nonlinearly generated by a self-interaction mechanism of the linearly amplified second mode waves. Several hypotheses regarding the origin of the low-frequency waves and their role in the transition process have been put forth. However, a clear understanding of the origin and role of these low-frequency disturbances in the transition process is difficult to attain from experiments and thus still not completely achieved. The nonlinear generation of higher harmonics and low-frequency disturbances is relevant because in high-speed boundary layers, second modes can reach very large amplitudes, which can lead to a considerable stretching of the transitional regime where these nonlinearly generated waves can then reach significant amplitudes and participate in the transition process. To shed light on this unresolved issue, numerical investigations were carried out for a flared cone at Mach 6. These calculations have shown that nonlinear interactions of sufficiently large-amplitude second mode waves can generate low-frequency disturbances. This was confirmed by a theoretical nonlinear interaction model.
Nonmonotonical Behavior of Thermal Modal Characteristics of a Plate with Geometrical Imperfection
Authors: Hu Yu-Jia , Gao Jingkun , Zhu Weidong , Li Haolin
Published: July 2023

Temperature has significant effects on the modal parameters of a structure. In general, as the temperature increases, the natural frequencies of a structure decrease with the softening of mechanical properties of the material at high temperature. However, it can be found from some thermal modal experiments that the natural frequencies of a structure do not monotonically decrease with temperature, which is regarded as the nonmonotonical behavior (NMB) of thermal modal characteristics of the structure. The mechanism of this experimental phenomenon is unclear. The first purpose of this work is to further confirm that the NMB of the thermal modal characteristics of a titanium plate with free boundary conditions occurs, and it is not affected by uncertain factors in the temperature field. The second purpose of this work is to use a thermally coupled dynamic shell model of the titanium plate with geometrical imperfection to explain the NMB of the titanium plate with free boundary conditions. By considering the significant effect of the geometrical imperfection of the plate on its thermal modal characteristics, the third purpose of this work is to propose a new method for thermal modal design by precreating the geometrical imperfection of the plate. Some interesting results of the thermal modal design of the titanium plate are presented.
Understanding the Complex Interplay of Governance, Systematic, and Structural Factors Affecting Service Delivery in South African Municipalities
Authors: Mamokhere John
Published: July 2023

South African municipalities have been plagued by poor service delivery, with many communities experiencing inadequate access to basic services such as clean water, sanitation, electricity, and waste removal. Despite the country’s progressive constitutional and legislative frameworks, the root causes of poor service delivery are complex and multifaceted. This study aims to explore the underlying reasons for service delivery challenges in South African municipalities, specifically focusing on the interplay between poor governance and structural and systematic factors. In other words, the study aims to identify and unpack the complex interplay between governance factors (such as corruption, political interference, and lack of accountability); structural factors (such as resource constraints, inadequate infrastructure, and capacity challenges); and systematic factors (such as historical legacies of apartheid, urban-rural divides, and socio-economic inequalities). The study employs a qualitative research approach, using document analysis to gather data. The data were analysed using thematic content analysis to identify the key themes and patterns that emerged from the data. The study draws on the New Public Management and Public Choice Theories to gain insights into the factors affecting service delivery. The findings highlight poor governance, urbanisation, corruption, political-administrative interference, political instability, and internal conflicts as major contributors to service delivery challenges in South African municipalities. Lastly, the study puts forth several recommendations to address these issues, including strengthening good governance and leadership, enhancing citizen participation, improving financial management, enhancing human resource capacity, fostering intergovernmental collaboration, reducing political-administrative interference, combating corruption, and addressing the impact of rapid urbanisation to promote sustainable service delivery.
Pages of history - Professor Lucian Ene – a teacher, doctor and scientist
Authors: Perlea Paula , Constantinescu Marian V.
Published: July 2023

Letter
Unusual case of falciform ligament internal hernia in pregnancy
Authors: Rajesh S. P. , Arunachalam Venkatesh Kasi , Selvaraj Swathigha , Arunachalam Pudhiavan , Ayyasamy Ganesan
Published: July 2023

Acute abdomen in pregnancy poses various diagnostic challenges due to limitations in imaging modalities. It can be due to an obstetric or non-obstetric cause. Internal hernia through congenital defects is rare. Although internal hernia is not prevalent in pregnancy, it is increasing nowadays due to previous surgical defects in the mesentery and peritoneal folds. We report an unusual case of an internal hernia through a defect in the falciform ligament in a pregnant female where imaging findings helped in timely surgical intervention.
JAK-STAT inhibitors in Immune mediated diseases: An Overview
Authors: Shah Ruchi Jayesh , Banerjee Sneha , Raychaudhuri Smriti , Raychaudhuri Siba P.
Published: July 2023

For any biological response, transmission of extracellular signals to the nucleus is required for DNA transcription and gene expression. In that respect, cytokines/chemokines are well-known inflammatory agents which play a critical role in signalling pathways by activating the Janus kinase–signal transducers and activators of transcription (JAK-STAT) signalling proteins (Janus kinase–signal transducers and activators of transcription) which are a group of intracellular kinase molecules. Cytokines are a category of small proteins (∼5–25 kDa) that play a major role in cell signalling and are major drivers of an autoimmune response. Here we will discuss the role of Janus kinase–signal transducers and activators of transcription kinase cascades in the inflammatory-proliferative cascades of autoimmune disease and about the recent progress in the development of oral synthetic Janus kinase inhibitors (JAKi) and their therapeutic efficacies in dermatologic and systemic autoimmune diseases.

Therapeutic efficacy of Janus kinase inhibitors is now well established in the treatment of array of autoimmune and inflammatory disease: spondylarthritis with a special focus on psoriatic arthritis (PsA) and its dermatologic manifestations (psoriasis) and ankylosing spondylitis (AS), atopic dermatitis (AD), alopecia areata (AA), rheumatoid arthritis (RA) and inflammatory bowel disease (IBD).

In addition to the first-generation Janus kinase inhibitors several new-generation Janus kinase inhibitors are currently being evaluated. It is expected that these Janus kinase inhibitors likely have higher potency and less adverse effects as compared to their predecessors. Here we have discussed: (1) the functional significance of the Janus kinase–signal transducers and activators of transcription kinase cascades in the inflammatory-proliferative processes of autoimmune diseases and its cellular/molecular mechanisms and (2) progress in the development of oral synthetic Janus kinase inhibitors and their therapeutic efficacies in several systemic and cutaneous autoimmune diseases.
Digital object identifier: What it is and why it matters?
Authors: Mondal Himel , Mondal Shaikat
Published: July 2023

Digital object identifiers (DOIs) have become essential tools in academic publishing for linking and identifying digital objects. This review examines the structure and assignment process of DOIs, shedding light on their critical importance in scholarly communication. DOIs consist of a unique alphanumeric string, including a prefix and a suffix, which serves as a persistent link to digital objects. By providing a standardized identifier, DOIs enhance the discoverability, accessibility, and referencing of various digital objects, including journal articles. The DOI also plays a crucial role in article promotion. With a DOI, authors, publishers, and researchers can effectively share and promote their articles, facilitating their discoverability in academic and research communities. However, challenges may arise with DOIs, such as non-functional links. This review provides troubleshooting tips for resolving such issues, including checking for typographical errors, validating the source, and seeking assistance from the DOI registration agency or the publisher.
Management of ovarian cyst through sepia given in LM potency – Case series
Authors: Rath Padmalaya , Saraswat Kruiti
Published: July 2023

Ovarian cysts are benign growths arising from the ovary, usually occurring in women of reproductive age. Ovarian cysts are fairly common in clinical practice and may be diagnosed symptomatically or incidentally through investigations like ultrasound sonography. This article reports two cases of women with ovarian cysts who were treated successfully with individualised homoeopathic medicines. The medicines were prescribed in fifty millesimal (LM) potency, based on homoeopathic principles of individualisation. The cases were further observed for 12 months without recurrence of symptoms. Both patients were assessed at baseline and end of treatment for pain using the visual analogue scale score and ultrasound reports. During treatment, both patients followed up every 20 days. After treatment ended, they were further observed for 12 months for symptom recurrence. In the second case, the MONARCH score was +7/13, indicating a positive causal attribution of homoeopathy in resolution of the pathological ovarian mass. Favourable results were observed through homoeopathic constitutional approach to ovarian cysts. Symptomatic relief and objective changes were seen, along with no recurrence of the symptoms and cysts. Homoeopathic Individualized medicines prescribed in fifty millesimal potency can serve beneficially in the management of surgical cases like ovarian cysts.
Mutate and Conjugate: A Method to Enable Rapid In-Cell Target Validation
Authors: Thomas Adam , Serafini Marta , Grant Emma , Coombs Edward , Bluck Joseph , Schiedel Matthias , McDonough Michael , Reynolds Jessica , Lee Bernadette , Platt Michael , Sharlandjieva Vassilena , Biggin Philip , Duarte Fernanda , Milne Thomas , Bush Jacob , Conway Stuart
Published: July 2023

Target validation remains a challenge in drug discovery, which leads to a high attrition rate in the drug discovery process, particularly in Phase II clinical trials. Consequently, new approaches to enhance target validation are valuable tools to improve the drug discovery process. Here we report the combination of site-directed mutagenesis and electrophilic fragments to enable the rapid identification of small molecules that selectively inhibit the mutant protein. Using the bromodomain- containing protein BRD4 as an example, we employed a structure-based approach to identify the L94C mutation in the first bromodomain of BRD4 [BRD4(1)] as having minimal effect on BRD4(1) function. We then screen a focused, KAc mimic-containing fragment set, and a diverse fragment library against the mutant and wild-type proteins, and identified a series of fragments that showed high selectivity for the mutant protein. These compounds were elaborated to include an alkyne click tag to enable the attachment of a fluorescent dye. These clickable compounds were then assessed in HEK293T cells, transiently expressing BRD4(1)WT or BRD4(1)L94C, to determine their selectivity for BRD4(1)L94C over other possible cellular targets. One compound was identified that shows very high selectivity for BRD4(1)L94C over all other proteins. This work provides proof-of-concept that the combination of site-directed mutagenesis and electrophilic fragments, in a mutant and conjugate approach, can enable rapid identification of small molecule inhibitors for an appropriately mutated protein of interest. This technology can be used to assess the cellular phenotype of inhibiting the protein of interest, and the electrophilic ligand provides a starting point for non-covalent ligand development.
Prediction of Binding Pose and Affinity of SARS-CoV-2 Main Protease and Repositioned Drugs by Combining Docking, Molecular Dynamics, and Fragment Molecular Orbital Calculations
Authors: Handa Yuma , Okuwaki Koji , Kawashima Yusuke , Hatada Ryo , Mochizuki Yuji , Komeiji Yuto , Tanaka Shigenori , Furuishi Takayuki , Yonemochi Etsuo , Honma Teruki , Fukuzawa Kaori
Published: July 2023

COVID-19 remains a global pandemic, necessitating the urgent development of more effective therapeutics. By combining molecular docking, molecular dynamics (MD), and fragment molecular orbital (FMO) calculations, the binding structure and properties with Mpro were predicted for Nelfinavir (NLF), which was identified as a candidate compound through drug repositioning targeting the Main Protease (Mpro) produced by the causative virus, SARS-CoV-2. For the four docking poses selected by scoring using FMO energy, 100 structures each from the MD trajectory were sampled, and FMO calculations were performed and ranked based on binding energy. Besides the interaction between NLF and each Mpro residue, the desolvation effect of the pocket affected the ranking order. Furthermore, we identified several residues important in ligand recognition, including Glu47, Asp48, Glu166, Asp187, and Gln189, all of which interacted strongly with NLF. Asn142 was mentioned as a residue with hydrogen bonds or CH/π interaction with NLF; however, it was considered a transient interacting residue because of its unstable structure. Moreover, the tert-butyl group of NLF had no interaction with Mpro. Identifying weak interactions provides candidates for substituting ligand functional groups and important suggestions for drug discovery using drug repositioning. Our approach provides a new guideline for structure-based drug design starting from a candidate compound whose complex crystal structure has not been obtained.
Elucidating the Competitive Adsorption of H2O and CO2 in CALF-20: New Insights for Enhanced Carbon Capture Metal-Organic Frameworks
Authors: Ho Ching-Hwa , Paesani Francesco
Published: July 2023

In light of the pressing need for efficient carbon capture solutions, our study investigates the simultaneous adsorption of water (H2O) and carbon dioxide (CO2) as a function of relative humidity in CALF-20, a highly scalable and stable metal-organic framework (MOF). Advanced computer simulations reveal that, due to their similar interactions with the frame- work, H2O and CO2 molecules compete for the same binding sites, occupying similar void regions within the CALF-20 pores. This competition results in distinct thermodynamic and dynamical behavior of H2O and CO2 molecules, depending on whether one or both guest species are present. Notably, the presence of CO2 molecules forces the H2O molecules to form more connected hydrogen-bond networks within smaller regions, slowing water reorien- tation dynamics and decreasing water entropy. Conversely, the presence of water speeds up the reorientation of CO2 molecules, decreases CO2 entropy, and increases the propensity for CO2 to be adsorbed within the framework due to stronger water-mediated interactions. Due to the competition for the same void spaces, both H2O and CO2 molecules exhibit slower diffusion when molecules of the other guest species are present. These findings offer valuable strategies and insights to enhance the differential affinity of H2O and CO2 for MOFs specifically designed for carbon capture applications.
Making Photocatalysts Screenable - A Milli Scale Multi-Batch Screening Photoreactor as Extension for the Modular Photoreactor
Authors: Kowalczyk Daniel , Knorr Gergely , Peneva Kalina , Ziegenbalg Dirk
Published: July 2023

Development and evaluation of new photocatalytic systems requires screening of large parameter spaces. For such investigations, a photonically characterized, simple, and low-cost multi-batch screening photoreactor is presented that enables the screening of up to 49 sealed 4 mL milli batch reactors. The reactor concept is based on theoretical contemplation of the geometrical and optical properties of suited reflector concepts and utilizes basic components of the modular photoreactor introduced recently. Raytracing, radiometry and chemical actinometry were used for the photonic characterization. Applicability of the screening setup under catalytic conditions was evaluated using a benchmark system for photoinduced hydrogen evolution consisting of [Ru(bpy)3](PF6)2 as photosensitizer, ascorbic acid as sacrificial agent and Mo3S132- as catalyst. Extending screening to metal-free organic photosensitizers, bimane compounds are reported as photosensitizers for photoinduced hydrogen evolution in various catalytic systems.
Analysis of Design Concepts: A Comparative Study of Pre- And Post- 2000 Printed Fabrics of Textile Printing Companies in Ghana
Authors: Pardie S. P. , Asinyo B. K. , Howard E. K. , Acquaye R.
Published: July 2023

Purpose: The paper aims to analyze and compare the design concepts in printed fabrics between the pre- and post-2000 periods in Ghana. By examining the changes in design trends, techniques, and motifs, the study also aims to identify the factors that have influenced the evolution of printed fabric designs over time.
Methods: This research adopts a concurrent embedded mixed method design, combining qualitative and quantitative methods. Primary data is collected through interviews with textile designers, manufacturers, and industry experts. A comprehensive analysis of printed fabric samples from pre- and post-2000 periods is conducted. The data collected is then analyzed using thematic analysis and statistical techniques.
Findings: This research provides insights into the changes in design concepts in the printed fabric industry in Ghana. The study reveals shifts in design trends, such as the adoption of digital printing techniques, the incorporation of contemporary motifs, and the influence of global fashion trends.
Research Limitation/Implications: The study's limitations include small sample size, limited representation of Ghana's textile printing industry's diverse design concepts, and insufficient exploration of production processes or market dynamics.
Practical Implication: Research highlights design changes in Ghanaian textiles, enabling designers to create innovative, marketable printed fabrics and manufacturers to adapt production processes.
Social Implication: The textile printing industry in Ghana significantly impacts cultural identity and economic development.
Originality/Value: This research adds value to the existing literature on the textile printing industry by comprehensively analysing the design concepts in printed fabrics in Ghana.
A Comparative Study of Ethics and Communication Patterns in Online and Face-to-face Learning
Authors: Rahmadianti Atika , Panduwinata Lifa Farida
Published: July 2023

The development of communication technology has resulted in a new style of communication. Communication between educators and students is no longer done face-to-face in schools. The role of interpersonal communication between educators and students shifts to Smartphones. This study uses a qualitative method with a descriptive approach by analyzing the data in the form of a brief description and using a triangulation technique to check the validity of the data. In this study, the ethics possessed by students are influenced by their surroundings and themselves. Using social media and communication patterns, students can acquire new language styles. But few students also pay less attention to ethics when talking to teachers. Face-to-face learning is considered very effective compared to online learning.
A psycholinguist approach of language and communication in autism spectrum disorder (ASD)
Authors: IRIMIA Ioana
Published: July 2023

Psycholinguistics is a field that combines methods and theories from psychology and linguistics to gain a fuller understanding of human language. The connection between the human psyche and language is the focus of research in psycholinguistics. Autism Spectrum Disorder (ASD) is a common and heterogeneous neurodevelopmental disorder characterized by language impairment, social and communicative deficits and repetitive behaviours. Echolalia is considered a predominant feature of ASD. Early intervention should be started as soon as a diagnosis is made, as social, play and language domains do not develop at the expected rate or in the expected multimodal, integrated manner. Using the language sample analysis technique, it is observed that echolalia and the number of abstract words do not influence mean utterance length, but the number of novel words correlates with mean utterance length. The psycholinguistic approach helps to gain a deeper understanding of language deficits and influences speech therapy intervention.