Apolipoprotein B, Residual Cardiovascular Risk After Acute Coronary Syndrome, and Effects of Alirocumab
Authors: Hagström Emil , Steg P. Gabriel , Szarek Michael , Bhatt Deepak L. , Bittner Vera A. , Danchin Nicolas , Diaz Rafael , Goodman Shaun G. , Harrington Robert A. , Jukema J. Wouter , Liberopoulos Evangelos , Marx Nikolaus , McGinniss Jennifer , Manvelian Garen , Pordy Robert , Scemama Michel , White Harvey D. , Zeiher Andreas M. , Schwartz Gregory G. , Schwartz Gregory G. , Bhatt Deepak L. , Bittner Vera A. , Diaz Rafael , Goodman Shaun G. , Harrington Robert A. , Jukema J. Wouter , Szarek Michael , White Harvey D. , Zeiher Andreas M. , Tricoci Pierluigi , Roe Matthew T. , Mahaffey Kenneth W. , Edelberg Jay M. , Hanotin Corinne , Lecorps Guillaume , Moryusef Angèle , Pordy Robert , Sasiela William J. , Tamby Jean-François , Diaz Rafael , Aylward Philip E , Drexel Heinz , Sinnaeve Peter , Dilic Mirza , Lopes Renato D. , Gotcheva Nina N , Goodman Shaun G. , Prieto Juan-Carlos , Yong Huo , López-Jaramillo Patricio , Pećin Ivan , Reiner Zeljko , Ostadal Petr , Poulsen Steen Hvitfeldt , Viigimaa Margus , Nieminen Markku S , Danchin Nicolas , Chumburidze Vakhtang , Marx Nikolaus , Liberopoulos Evangelos , Carlos Pablo , Valdovinos Montenegro , Tse Hung-Fat , Kiss Robert Gabor , Xavier Denis , Zahger Doron , Valgimigli Marco , Kimura Takeshi , Kim Hyo Soo , Kim Sang-Hyun , Erglis Andrejs , Laucevicius Aleksandras , Kedev Sasko , Yusoff Khalid , Ramos López Gabriel Arturo , Alings Marco , White Harvey D. , Halvorsen Sigrun , Correa Flores Roger M , Sy Rody G. , Budaj Andrzej , Morais Joao , Dorobantu Maria , Karpov Yuri , Ristic Arsen D. , Chua Terrance , Murin Jan , Fras Zlatko , Dalby Anthony J , Tuñón José , de Silva H. Asita , Hagström Emil , Landmesser Ulf , Müller Christian , Chiang Chern-En , Sritara Piyamitr , Guneri Sema , Parkhomenko Alexander , Ray Kausik K. , Moriarty Patrick M. , Roe Matthew T. , Vogel Robert , Chaitman Bernard , Kelsey Sheryl F. , Olsson Anders G. , Rouleau Jean-Lucien , Simoons Maarten L. , Alexander Karen , Meloni Chiara , Rosenson Robert , Sijbrands Eric J.G. , Tricoci Pierluigi , Alexander John H. , Armaganijan Luciana , Bagai Akshay , Bahit Maria Cecilia , Brennan J. Matthew , Clifton Shaun , DeVore Adam D. , Deloatch Shalonda , Dickey Sheila , Dombrowski Keith , Ducrocq Grégory , Eapen Zubin , Endsley Patricia , Eppinger Arleen , Harrison Robert W. , Hess Connie Ng , Hlatky Mark A. , Jordan Joseph Dedrick , Knowles Joshua W. , Kolls Bradley J. , Kong David F. , Leonardi Sergio , Lillis Linda , Lopes Renato D. , Maron David J. , Mahaffey Kenneth W. , Marcus Jill , Mathews Robin , Mehta Rajendra H. , Mentz Robert J. , Moreira Humberto Graner , Patel Chetan B. , Pereira Sabrina Bernardez , Perkins Lynn , Povsic Thomas J. , Puymirat Etienne , Roe Matthew T. , Jones William Schuyler , Shah Bimal R. , Sherwood Matthew W. , Stringfellow Kenya , Sujjavanich Darin , Toma Mustafa , Trotter Charlene , van Diepen Sean F.P. , Wilson Matthew D. , Tze-Kay Yan Andrew , Schiavi Lilia B , Garrido Marcelo , Alvarisqueta Andrés F , Sassone Sonia A , Bordonava Anselmo P , Alves De Lima Alberto E , Schmidberg Jorge M , Duronto Ernesto A , Caruso Orlando C , Novaretto Leonardo P , Hominal Miguel Angel , Montaña Oscar R , Caccavo Alberto , Gomez Vilamajo Oscar A , Lorenzatti Alberto J , Cartasegna Luis R , Paterlini Gustavo A , Mackinnon Ignacio J , Caime Guillermo D , Amuchastegui Marcos , Salomone Oscar , Codutti Oscar R , Jure Horacio O , Bono Julio OE , Hrabar Adrian D , Vallejos Julio A , Ahuad Guerrero Rodolfo A , Novoa Federico , Patocchi Cristian A , Zaidman Cesar J , Giuliano Maria E , Dran Ricardo D , Vico Marisa L , Carnero Gabriela S , Guzman Pablo N , Medrano Allende Juan C , Garcia Brasca Daniela F , Bustamante Labarta Miguel H , Nani Sebastian , Blumberg Eduardo DS , Colombo Hugo R , Liberman Alberto , Fuentealba Victorino , Luciardi Hector L , Waisman Gabriel D , Berli Mario A , Garcia Duran Ruben O , Cestari Horacio G , Luquez Hugo A , Giordano Jorge A , Saavedra Silvia S , Zapata Gerardo , Costamagna Osvaldo , Llois Susana , Waites Jonathon H , Collins Nicholas , Soward Allan , Aylward Philip E , Hii Chris LS , Aylward Philip E , Shaw James , Arstall Margaret A , Horowitz John , Ninio Daniel , Rogers James F , Colquhoun David , Oqueli Flores Romulo E , Roberts-Thomson Philip , Raffel Owen , Lehman Sam J , Aroney Constantine , Coverdale Steven GM , Garrahy Paul J , Starmer Gregory , Sader Mark , Carroll Patrick A , Dick Ronald , Zweiker Robert , Hoppe Uta , Drexel Heinz , Huber Kurt , Berger Rudolf , Delle-Karth Georg , Frey Bernhard , Weidinger Franz , Faes Dirk , Hermans Kurt , Pirenne Bruno , Leone Attilio , Hoffer Etienne , Sinnaeve Peter , Vrolix Mathias CM , Wolf Luc De , Wollaert Bart , Castadot Marc , Dujardin Karl , Beauloye Christophe , Vervoort Geert , Striekwold Harry , Convens Carl , Roosen John , Barbato Emanuele , Claeys Marc , Cools Frank , Terzic Ibrahim , Barakovic Fahir , Midzic Zlatko , Pojskic Belma , Fazlibegovic Emir , Dilic Mirza , Durak-Nalbantic Azra , Kulić Mehmed , Vulic Dusko , Muslibegovic Adis , Goronja Boris , Reis Gilmar , Sousa Luciano , Nicolau Jose C , Giorgeto Flavio E , Silva Ricardo P , Maia Lilia Nigro , Rech Rafael , Rossi Paulo RF , Cerqueira Maria José AG , Duda Norberto , Kalil Renato , Kormann Adrian , Abrantes José Antonio M , Filho Pedro Pimentel , Soggia Ana Priscila , de Santos Mayler ON , Neuenschwander Fernando , Bodanese Luiz C , Michalaros Yorghos L , Eliaschewitz Freddy G , Vidotti Maria H , Leaes Paulo E , Botelho Roberto V , Kaiser Sergio , Manenti Euler Roberto F Fernandes , Precoma Dalton B , Moura Jorge Jose C , Silva Pedro , Silveira Jose A , Saporito Wladmir , Neto Jose A Marin , Feitosa Gilson S , Ritt Luiz Eduardo F , de Souza Juliana A , Costa Fernando , Souza Weimar KSB , Reis Helder JL , Lopes Renato D. , Machado Leandro , Aidar Ayoub José Carlos , Todorov Georgi V , Nikolov Fedya P , Velcheva Elena S , Tzekova Maria L , Benov Haralambi O , Petranov Stanislav L , Tumbev Haralin S , Shehova-Yankova Nina S , Markov Dimitar T , Raev Dimitar H , Mollov Mihail N , Kichukov Kostadin N , Ilieva- Pandeva Katya A , Gotcheva Nina N , Ivanova Raya , Gospodinov Maryana , Mincheva Valentina M , Lazov Petar V , Dimov Bojidar I , Senaratne Manohara , Stone James , Kornder Jan , Pearce Stephen , Dion Danielle , Savard Daniel , Pesant Yves , Pandey Amritanshu , Robinson Simon , Gosselin Gilbert , Vizel Saul , Hoag Gordon , Bourgeois Ronald , Morisset Anne , Sabbah Eric , Sussex Bruce , Kouz Simon , MacDonald Paul , Diaz Ariel , Michaud Nicolas , Fell David , Leung Raymond , Vuurmans Tycho , Lai Christopher , Nigro Frank , Davies Richard , Nogareda Gustavo , Vijayaraghavan Ram , Ducas John , Lepage Serge , Mehta Shamir , Cha James , Dupuis Robert , Fong Peter , Lutchmedial Sohrab , Rodes-Cabau Josep , Fadlallah Hussein , Cleveland David , Huynh Thao , Bata Iqbal , Hameed Adnan , Pincetti Cristian , Potthoff Sergio , Prieto Juan C , Acevedo Monica , Aguirre Arnoldo , Vejar Margarita , Yañez Mario , Araneda Guillermo , Fernandez Mauricio , Perez Luis , Varleta Paola , Florenzano Fernando , Huidobro Laura , Raffo Carlos A , Olivares Claudia , Nahuelpan Leonardo , Montecinos Humberto , Chen Jiyan , Dong Yugang , Huang Weijian , Wang Jianzhong , Huang Shi’An , Yao Zhuhua , Li Xiang , Cui Lan , Lin Wenhua , Sun Yuemin , Wang Jingfeng , Li Jianping , Zhang Xuelian , Zhu Hong , Chen Dandan , Huang Lan , Dong Shaohong , Su Guohai , Xu Biao , Su Xi , Cheng Xiaoshu , Lin Jinxiu , Zong Wenxia , Li Huanming , Feng Yi , Xu Dingli , Yang Xinchun , Ke Yuannan , Lin Xuefeng , Zhang Zheng , Zheng Zeqi , Luo Zhurong , Chen Yundai , Ding Chunhua , Zhong Yi , Zheng Yang , Li Xiaodong , Peng Daoquan , Zhao Shuiping , Li Ying , Liu Xuebo , Wei Meng , Liu Shaowen , Yu Yihua , Qu Baiming , Jiang Weihong , Zhou Yujie , Zhao Xingsheng , Yuan Zuyi , Guo Ying , Xu Xiping , Shi Xubo , Ge Junbo , Fu Guosheng , Bai Feng , Fang Weiyi , Shou Xiling , Yang Xiangjun , Wang Jian’An , Xiang Meixiang , Sun Yingxian , Lu Qinghua , Zhang Ruiyan , Zhu Jianhua , Xu Yizhou , Fan Zhongcai , Li Tianchang , Wu Chun , Jaramillo Nicolas , Vallejo Gregorio Sanchez , Luna Botia Diana C , Lopez Rodrigo Botero , De Salazar Dora I Molina , Bonfanti Alberto J Cadena , Aroca Carlos Cotes , Higuera Juan Diego , Blanquicett Marco , Barrera Silva Sandra I , Garcia Lozada Henry J , Coronel Arroyo Julian A , Accini Mendoza Jose L , Fernandez Ruiz Ricardo L , Quintero Ossa Alvaro M. , Manzur Jatin Fernando G , Sotomayor Herazo Aristides , Parada Jeffrey Castellanos , Arambula Rafael Suarez , Urina Triana Miguel A , Trujillo Angela M Fernandez , Strozzi Maja , Car Siniša , Miličić Davor , Lovrić Benčić Martina , Pintarić Hrvoje , Prvulović Đeiti , Šikić Jozica , Peršić Viktor , Mileta Dean , Štambuk Kresimir , Babić Zdravko , Tomulic Vjekoslav , Lukenda Josip , Mejic-Krstulovic Stanka , Starcevic Boris , Spinar Jindrich , Horak David , Velicka Zdenek , Alan David , Machova Vilma , Linhart Ales , Novotny Vojtech , Kaucak Vladimir , Rokyta Richard , Naplava Robert , Coufal Zdenek , Adamkova Vera , Podpera Ivo , Zizka Jiri , Motovska Zuzana , Marusincova Ivana , Ostadal Petr , Heinc Petr , Kuchar Jiri , Povolny Petr , Matuska Jiri , Poulsen Steen H , Raungaard Bent , Clemmensen Peter , Bang Lia E , May Ole , Bøttcher Morten , Hove Jens D , Frost Lars , Gislason Gunnar , Larsen John , Johansen Peter Betton , Hald Flemming , Johansen Peter , Jeppesen Jørgen , Nielsen Tonny , Kristensen Kjeld S , Walichiewicz Piotr Maria , Lomholdt Jens D , Klausen Ib C , Nielsen Peter Kaiser , Davidsen Flemming , Videbaek Lars , Viigimaa Margus , Soots Mai , Vahula Veiko , Hedman Anu , Soopõld Üllar , Märtsin Kaja , Jurgenson Tiina , Kristjan Arved , Nieminen Markku S , Vikman Saila , Huikuri Heikki , Airaksinen Juhani , Coste Pierre , Ferrari Emile , Danchin Nicolas , Morel Olivier , Montalescot Gilles , Machecourt Jacques , Barone-Rochette Gilles , Mansourati Jacques , Cottin Yves , Steg Ph. Gabriel , Leclercq Florence , Belhassane Abdelkader , Delarche Nicolas , Boccara Franck , Paganelli Franck , Clerc Jérôme , Schiele Francois , Aboyans Victor , Probst Vincent , Berland Jacques , Lefèvre Thierry , Chumburidze Vakhtang , Khintibidze Irakli , Shaburishvili Tamaz , Pagava Zurab , Ghlonti Ramaz , Lominadze Zaza , Khabeishvili George , Hemetsberger Rayyan , Edward Kemala , Rauch-Kröhnert Ursula , Stratmann Matthias , Appel Karl-Friedrich , Schmidt Ekkehard , Omran Heyder , Stellbrink Christoph , Dorsel Thomas , Lianopoulos Emmanouil , Vöhringer Hans Friedrich , Marx Roger , Zirlik Andreas , Schellenberg Detlev , Heitzer Thomas , Laufs Ulrich , Werner Christian , Marx Nikolaus , Gielen Stephan , Nuding Sebastian , Winkelmann Bernhard , Behrens Steffen , Sydow Karsten , Karakas Mahir , Simonis Gregor , Muenzel Thomas , Werner Nikos , Leggewie Stefan , Böcker Dirk , Braun- Dullaeus Rüdiger , Toursarkissian Nicole , Jeserich Michael , Weißbrodt Matthias , Schaeufele Tim , Weil Joachim , Völler Heinz , Waltenberger Johannes , Natour Mohammed , Schmitt Susanne , Müller-Wieland Dirk , Steiner Stephan , Heidenreich Lothar , Offers Elmar , Gremmler Uwe , Killat Holger , Rieker Werner , Patsilinakos Sotiris , Kartalis Athanasios , Manolis Athanassios , Sionis Dimitrios , Chachalis Geargios , Liberopoulos Evangelos , Skoumas Ioannis , Athyros Vasilios , Vardas Panagiotis , Parthenakis Frangkiskos , Hahalis Georgios , Lekakis John , Hatzitolios Apostolos , Fausto Ovando Sergio R , Montenegro Valdovinos Pablo Carlos , Arango Benecke Juan L , Rodriguez De Leon Edgar R , Yan Bryan PY , Siu David CW , Turi Tibor , Merkely Bela , Gabor Kiss Robert , Ungi Imre , Lupkovics Geza , Nagy Lajos , Katona András , Édes István , Müller Gábor , Horvath Iván , Kapin Tibor , Szigeti Zsolt , Faluközy József , Kumbla Mukund , Sandhu Manjinder , Annam Sharath , Reddy Proddutur Naveen , Regella Reddy , Premchand Rajendra K , Mahajan Ajaykumar , Pawar Sudhir , Abhyanakar Atul D , Kerkar Prafulla , Govinda Ravishankar A , Oomman Abraham , Sinha Dhurjati , Patil Sachin N , Kahali Dhiman , Sawhney Jitendra , Joshi Abhijeet B , Chaudhary Sanjeev , Harkut Pankaj , Guha Santanu , Porwal Sanjay , Jujjuru Srimannarayana , Pothineni Ramesh B , Monteiro Minguel R , Khan Aziz , Iyengar Shamanna S , Grewal Jasprakash Singh , Chopda Manoj , Fulwani Mahesh C , Patange Dr. Aparna , Sachin Patil , Chopra Vijay K , Goyal Naresh K , Shinde Rituparna , Manakshe Gajendra V , Patki Nitin , Sethi Sumeet , Munusamy Vengatesh , Sunil Thanvi Sunil Karnaand , Adhyapak Srilakshmi , Patil Chandrakant , Pandurangi Ulhas , Mathur Rishabh , Gupta Jugal , Kalashetti Suhas , Bhagwat Ajit , Raghuraman Bagirath , Kumar Yerra Shiv , Bhansali Prasant , Borse Rohidas , Rahul Patil , Das Srihari , Kumar Vinay , Abdullakutty Jabir , Saathe Shireesh , Palimkar Priya , Abdullkutty Jabir , Sathe Shireesh , Atar Shaul , Shechter Michael , Mosseri Morris , Arbel Yaron , Ehud Chorin , Ofer Havakuk , Lotan Chaim , 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Busmane Arija , Pontaga Natalija , Strelnieks Aldis , Mintale Iveta , Sime Iveta , Petrulioniene Zaneta , Kavaliauskiene Roma , Jurgaitiene Ruta , Sakalyte Gintare , Slapikas Rimvydas , Norkiene Sigute , Misonis Nerijus , Kibarskis Aleksandras , Kubilius Raimondas , Bojovski Stojko , Kedev Sasko , Lozance Nensi , Kjovkaroski Aleksandar , Doncovska Snezana , Ong Tiong Kiam , Kasim Sazzli , Maskon Oteh , Kandasamy Balachandran , Yusoff Khalid , Liew Houng B , Wan Mohamed Wan Mohd Izani , Castillo Armando García , Ramos López Gabriel Arturo , Calvillo Jorge Carrillo , Campos Pedro Fajardo , Núñez Fragoso Juan Carlos , Bayram Llamas Edmundo Alfredo , Alcocer Gamba Marco Antonio , Madrigal Jaime Carranza , González Salas Luis Gerardo , Rosas Enrique López , González Díaz Belinda , Vázquez Eduardo Salcido , Nacoud Ackar Alfredo , Llamas Esperón Guillermo Antonio , Martínez Sánchez Carlos Rodolfo , De Leon María Guerrero , Suarez Otero Rodrigo , Salmón Guillermo Fanghänel , Pérez Ríos Jesús Antonio , Garza Ruíz José Angel , Alings Marco , Breedveld Robert W , Feenema-Aardema Margriet , Borger-Van Der Burg Alida , Hoogslag Pieter AM , Suryapranata Harry , Oomen Antonius , Van Haelst Paulus , Feenema-Aradema Margriet , Wiersma Jacobijne J , Basart Dirk , Van Der Wal Ruud MA , Zwart Peter , Monraats Pascalle , Van Kesteren Henricus , Karalis Ioannis , Jukema Johan , Verdel Gerardus JE , Brueren Bart RG , Troquay Roland PTh , Viergever Eric P , Al-Windy Nadea YY , Bartels Gerard L , Cornel Jan H , Hermans Walter RM , Herrman Johannes PR , Bos Robert J , Groutars Reginald GEJ , Van Der Zwaan Coenraad C , Kaplan Refik , Ronner Eelko , Groenemeijer Bjorn E , Bronzwaer Patrick NA , Liem Anho AH , Rensing Bernard JWM , Bokern Marcel JJA , Nijmeijer Remco , Hersbach Ferry MRJ , Willems Frank F , Gosselink Antonius TM , Rasoul Saman , Elliott John , Wilkins Gerard , Fisher Raewyn , Scott Douglas , Hart Hamish , Stewart Ralph , Harding Scott , Ternouth Ian , Fisher Nicholas , Wilson Samuel , Aitken Denise , Anscombe Russell , Davidson Laura , Tomala Tadeusz , Nygård Ottar , Sparby Jon Arne , Andersen Kjell , Gullestad Lars , Jortveit Jarle , Munk Peter S , Singsaas Erlend gyllensten , Halvorsen Sigrun , Hurtig Ulf , Correa Flores Roger M , Calderon Ticona Jorge R , Durand Velasquez Julio R , Negron Miguel Sandra A , Sanabria Perez Enrique S , Carrion Chambilla Jesus M , Chavez Ayala Carlos A , Castillo Leon Reynaldo P , Vargas GonzalesC Rolando J , Hernandez Zuniga Jose D , Camacho Cosavalente Luis A , Bravo Mannucci Jorge E , Landeo Javier Heredia , Llerena Navarro Nassip C , Roldan Concha Yudy M , Rodriguez Chavez Víctor E , Anchante Hernandez Henry A , Zea Nunez Carlos A , Ramos Walter Mogrovejo , Ferrolino Arthur , Sy Rosa Allyn G , Tirador Louie , Sy Rody G. , Matiga Generoso , Coching Raul Martin , Bernan Alisa , Rogelio Gregorio , Morales Dante D. , Tan Edgar , Sulit Dennis Jose , Wlodarczak Adrian , Skonieczny Grzegorz , Pawlowicz Lidia , Wojewoda Pawel , Busz-Papiez Benita , Bednarski Janusz , Goch Aleksander , Staneta Pawel , Dulak Elzbieta , Budaj Andrzej , Saminski Krzysztof , Krasowski Wlodzimierz , Sudnik Wanda , Zurakowski Aleksander , Skorski Marcin , Lysek Roman , Miklaszewicz Beata , Lipko Jan Andrzej , Kostarska-Srokosz Edyta , Piepiorka Marek , Drzewiecka Anna , Stasiewski Arkadiusz , Blicharski Tomasz , Bystryk Leszek , Szpajer Michal , Korol Marek , Czerski Tomasz , Gniot Jacek , Lubinski Andrzej , Gorny Jerzy , Franek Edward , Raczak Grzegorz , Szwed Hanna , Monteiro Pedro , Mesquita Bastos Jose , Pereira Helder H , Morais Joao , Seixo Filipe , Mendonça Carlos , Botelho Ana , Caetano Francisca , Minescu Bogdan , Istratoaie Octavian , Tesloianu Dan N , Dorobantu Maria , Cristian Gabriel , Dumitrescu Silviu , Podoleanu Cristian GC , Constantinescu Mircea CA , Bengus Cristina M , Militaru Constantin , Rosu Doina , Parepa Irinel R , Matei Adrian V , Alexandru Tom M , Malis Mihaela , Coman Ioan , Shvarts Yury , Orlikova Olga , Kobalava Zhanna , Barbarash Olga L , Markov Valentin , Lyamina Nadezhda , Gordienko Alexander , Zrazhevsky Konstantin , Vishnevsky Alexander Y , Gurevich Victor , Stryuk Raisa , Lomakin Nikita V , Bokarev Igor , Khlevchuk Tatiana , Shalaev Sergey , Khaisheva Larisa , Chizhov Petr , Viktorova Inna , Osokina Natalya , Shchekotov Vladimir , Akatova Evgenia , Chumakova Galina , Libov Igor , Voevoda Mikhail I , Tretyakova Tatyana V , Baranov Evgeny , Shustov Sergey , Yakushin Sergey , Gordeev Ivan , Khasanov Niiaz , Reshetko Olga , Sotnikova Tatiana , Molchanova Olga , Nikolaev Konstantin , Gapon Liudmila , Baranova Elena , Kosmachova Elena , Karpov Yuriy , Karpov Yuri , Povzun Anton , Egorova Liudmila , Tyrenko Vadim V , Ivanov Igor G , Ilya Masterov , Kanorsky Sergey , Simic Dragan , Ivanovic Nikola , Davidovic Goran , Tasic Nebojsa , Asanin Milika R. , Stojic Stevo , Apostolovic Svetlana R. , Ilic Stevan , Tosic Biljana Putnikovic , Stankovic Aleksandar , Arandjelovic Aleksandra , Radovanovic Slavica , Todic Branislava , Ristic Arsen D. , Balinovac Jovan , Dincic Dragan V. , Seferovic Petar , Karadzic Ana , Dodic Slobodan , Dimkovic Sinisa , Jakimov Tamara , Poh Kian-Keong , Yee Ong Hean , Tang I-Shing Justin , Micko Karol , Nociar Jan , Pella Daniel , Fulop Peter , Hranai Marian , Palka Juraj , Mazur Juraj , Majercák Ivan , Dzupina Andrej , Fazekas František , Gonsorcik Jozef , Bugan Viliam , Murin Jan , Selecky Juraj , Kamensky Gabriel , Strbova Jaroslava , Smik Rudolf , Dukat Andrej , Olexa Peter , Žuran Ivan , Poklukar Janez , Šuligoj Nataša Černič , Cevc Matija , Fras Zlatko , Cyster Henry P , Ranjith Naresh , Corbett Clive , Bayat Junaid , Makoali Makotoko Ellen , du Toit Theron Hendrik , Kapp Ilse E , de V Basson Matthys M , Lottering Hanlie , Aswegen Dina Van , Van Zyl Louis J , Sebastian Peter J , Pillay Thayabran , Saaiman Jan A , Commerford Patrick J , Cassimjee Soraya , Riaz Garda , Ebrahim Iftikhar O , Sarvan Mahomed , Mynhardt Joseph H , Dalby Anthony J , Reuter Helmuth , Moodley Rajendran , Vida Manuel , Fillat Angel R. Cequier , Peris Vicente Bodí , Jimenez Francisco Fuentes , Marín Francisco , Cruz Fernández Jose M , Hidalgo Urbano Rafael Jesus , Gil-Extremera Blas , Toledo Pablo , Worner Diz Fernando , Garcia-Dorado David , Iñiguez Andres , Gonzalez-Juanatey Jose R , Portales Javier Fernandez , Murillo Fernando Civeira , Pericas Laia Matas , Zamorano Jose Luis , De Mora Martin Manuel , Cortada Jordi Bruguera , Alonso Martin Joaquin J , Serrano Antolin Jose Maria , De Berrazueta Fernández José R , Vázquez de Prada José Antonio , Díaz Fernández Jose Francisco , García Lledó José Alberto , Cosín Sales Juan , Rodriguez Javier Botas , Tragant Gabriel Gusi , Benedicto Amparo , Gonzalez-Juanatey Carlos , Camprubí Potau Mercedes , Perez Ignacio Plaza , De La Tassa César Morís , Rincon Pablo Loma-Osorio , Recena Javier Balaguer , Escudier Juan M , Payeras Antonio Coca , Orcajo Norberto Alonso , Constantine Godwin , Haniffa Ruvaiz , Tissera Nirmali , Amarasekera Stanley , Ponnamperuma Chandrike , Fernando Nimali , Fernando Kaputella , Jayawardena Jayanthimala , Wijeyasingam Santharaj , Ranasinghe Gotabhaya , Ekanayaka Ruvan , Mendis Sepalika , Senaratne Vajira , Mayurathan Gnanamoorthy , Rajapaksha Ajantha , Sirisena Thilak , Herath Jagath I , Amarasena Naomali , Berglund Stefan , Rasmanis Gundars , Hagström Emil , Vedin Ola , Witt Nils , Mourtzinis Georgios , Nicol Peter , Hansen Ole , Romeo Stefano , Jensen Steen Agergaard , Torstensson Ingemar , Ahremark Ulf , Sundelin Torbjörn , Moccetti Tiziano , Müller Christian , Mach Francois , Binde Ronald , Landmesser Ulf , Gämperli Oliver , Chiang Chern-En , Tsai Wei- Chuan , Ueng Kwo-Chang , Lai Wen-Ter , Liu Ming-En , Hwang Juey- Jen , Yin Wei-Hsian , Hsieh I-Chang , Hsieh Ming-Jer , Hsiang Lin Wei , Kuo Jen-Yuan , Huang Tsuei-Yuan , Fang Chih-Yuan , Kaewsuwanna Pinij , Soonfuang Wasant , Jintapakorn Woravut , Sukonthasarn Apichard , Sritara Piyamitr , Wongpraparut Nattawut , Sastravaha Krisada , Sansanayudh Nakarin , Kehasukcharoen Wirash , Piyayotai Dilok , Chotnoparatpat Paiboon , Camsari Ahmet , Kultursay Hakan , Guneri Sema , Mutlu Bulent , Ersanli Murat , Demirtas Mustafa , Kirma Cevat , Ural Ertan , Koldas Lale , Karpenko Oleksandr , Prokhorov Alexander , Vakaluyk Ihor , Myshanych Halyna , Reshotko Dmytro , Batushkin Valeriy , Rudenko Leonid , Kovalskyi Ihor , Kushnir Mykola , Tseluyko Vira , Mostovoy Yuriy , Stanislavchuk Mykola , Kyiak Yulian , Karpenko Yuriy , Malynovsky Yaroslav , Klantsa Andriy , Kutniy Oles , Amosova Ekaterina , Tashchuk Viktor , Leshchuk Oleh , Parkhomenko Alexander , Rishko Mykola , Kopytsya Mykola , Yagensky Andriy , Vatutin Mykola , Bagriy Andriy , Barna Olga M , Ushakov Olexiy , Dzyak Georgiy , Goloborodko Borys , Rudenko Anatolii , Zheleznyy Volodymyr , Trevelyan Jasper , Zaman Azfar , Lee Kaeng , Moriarty Andrew , Aggarwal Rajesh K , Clifford Piers , Wong Yuk- Ki , Iqbal Syed MR , Subkovas Eduardas , Braganza Denise , Sarkar David , Storey Robert , Griffiths Huw , Mcclure Sam , Muthusamy Rangasamy , Smith Simon , Kurian John , Levy Terry , Barr Craig , Kadr Honer , Gerber Robert , Simaitis Audrius , Soran Handrean , Brodison Adrian , Ayaz Mohammad , Cheema Muhammad , Oliver Richard , Thackray Simon , Mudawi Telal , Rahma Gohar , Sultan Ayyaz , Reynolds Timothy , Sharman David , Spriging david , Butler Rob , Wilkinson Peter , Lip Gregory YH , Ossei-Gerning Nicholas , Vardi Gil , Baldari Duccio , Brabham David , Treasure II Charles , Dahl Charles , Palmer Bruce , Wiseman Alan , Khan Abul , Puri Sanjeev , Mohart Ann Elizabeth , Ince Carlos , Flores Enrique , Wright Scott , Cheng Shi-Chi , Rosenberg Michael , Rogers William , Kosinski Edward , Forgosh Les , Waltman Jonathan , Shoukfeh Mohammad , Dagher Georges , Cambier Patrick , Lieber Ira , Kumar Priya , East Cara , Krichmar Perry , Hasan Mian , White Lindsey , Knickelbine Thomas , Haldis Thomas , Gillespie Eve , Amidon Thomas , Suh David , Arif Imran , Abdallah mouhamad , Akhter Faiq , Carlson Eric , D’Urso Michael , El- Ahdab Fadi , Nelson William , Moriarty Katie , Harris Barry , Cohen Steven , Carter Luther , Doty Daniel , Sabatino Kenneth , Haddad Tariq , Rao Sunder , Mulkay Angel , Jovin Ion , Klancke Kim , Malhotra Vinay , Devarapalli Sai K , Koren Michael , Chandna Harish , Dodds III George , Goraya Tauqir , Bengston James , Janik Matthew , Moran Joseph , Sumner Andrew , Kobayashi John , Davis William , Yazdani Shahram , Pasquini John , Thakkar Maitreya , Vedere Amarnath , Leimbach Wayne , Rider James , fenton Sarah , Singh Narendra , Shah Anil V , Moriarty Patrick M. , Janosik Denise , Pepine Carl , Berman Brett , Gelormini Joseph , Daniels Christopher , Richard Kerensky , Keating Friederike , Kondo Nicholas I , Shetty Sanjay , Levite Howard , Waider Winfried , Takata Theodore , Abu-Fadel Mazen , Shah Vipul , Aggarwal Rahul , Kumar Anil , Hattler Brack , Do Rose , Link Chad , Bortnick Anna , Kinzfogl III George , Ghitis Arnold , Larry John , Teufel Edward , Kuhlman Peter , Mclaurin Brent , Zhang Wenwu , Thew Stephen , Abbas Jalal , White Matthew , Islam Othman , Subherwal Sumeet , Ranadive Nandkishore , Vakili Babak , Gring Christian , Henderson David , Schuchard Timothy , Farhat Naim , Kline Geoffrey , Mahal Sharan , Whitaker Jack , Speirs Shawn , Andersen Rolf , Daboul Nizar , Horwitz Phillip , Zahr Firas , Ponce George , Jafar Zubair , Mcgarvey Joseph , Panchal Vipul , Voyce Stephen , Blok Thomas , Sheldon William , Azizad Masoud M , Schmalfuss Carsten , Picone Mark , Pederson Robert , Herzog William , Friedman Keith , Lindsey Jason , Timothy Eichenlaub , Leonard Parilak , Lepor Norman , El Shahawy Mahfouz , Weintraub Howard , Irimpen Anand , Alonso Alvaro , May Wade , Christopher Daniels , Galski Thomas , Chu Alan , Mody Freny , Ramin Ebrahimi , Hodes Zachary , Rossi Joseph , Rose Gregory , Fairlamb James , Lambert Charles , Raisinghani Ajit , Abbate Antonio , Vetrovec George , King Marilyn , Carey Charles , Gerber Jaime , Younis Liwa , Park Hyeun (Tom) , Vidovich Mladen , Knutson Thomas , Friedman Dennis , Chaleff Fred , Loussararian Arthur , Rozeman Phillip , Kimmelstiel Carey , Kuvin Jeffrey , Silver Kevin , Foster Malcolm , Tonnessen Glen , Espinoza Andrey , Amlani Mohamadali , Wali Andreas , Malozzi Christopher , Jong Geert T , Massey Clara , Wattanakit Keattiyoat , O’Donnell Philip J. , Singal Dinesh , Jaffrani Naseem , Banuru Sridhar , Fisher Daniel , Xenakis Mark , Perlmutter Neal , Bhagwat Ravi , Strader James , Blonder Ronald , Akyea-Djamson Ayim , Labroo Ajay , Lee Kwan , Marais H. John , Claxton Edmund , Weiss Robert , Kathryn Rohr , Berk Martin , Rossi Peter , Joshi Parag , Khera Amit , Khaira Ajit S , Kumkumian Greg , Lupovitch Steven , Purow Joshua , Welka Stephen , Hoffman David , Fischer Stuart , Soroka Eugene , Eagerton Donald , Pancholy Samir , Ray Michael , Erenrich Norman , Farrar Michael , Pollock Stewart , French William J , Diamantis Steve , Guy Douglas , Gimple Lawrence , Neustel Mark , Schwartz Steven , Pereira Edward , Albert Seals , Spriggs Douglas , Strain Janet , Mittal Suneet , Vo Anthony , Chane Majed , Hall Jason , Vijay Nampalli , Lotun Kapildeo , Lester F. Martin , Nahhas Ahed , Pope Theodore , Nager Paul , Vohra Rakesh , Sharma Mukesh , Bashir Riyaz , Ahmed Hinan , Berlowitz Michael , Fishberg Robert , Barrucco Robert , Yang Eric , Radin Michael , Sporn Daniel , Stapleton Dwight , Eisenberg Steven , Landzberg Joel , Mcgough Martin , Turk Samir , Schwartz Michael , Sundram P. Sandy , Jain Diwakar , Zainea Mark , Bayron Carlos , Karlsberg Ronald , Dohad Suhail , Lui Henry , Keen William , Westerhausen Donald , Khurana Sandeep , Agarwal Himanshu , Birchem Jessica , Penny William , Chang Mark , Murphy Sherrill , Henry John , Schifferdecker Branislav , Gilbert John M , Chalavarya Gopal , Eaton Charles , Schmedtje John F , Christenson Stuart , Dotani Imran , Denham Douglas , Macdonell Alexander , Gibson Paul , Rahman Aref , Al Joundi Tammam , Assi Nizar , Conrad Gary , Kotha Purushotham , Love Michael , Giesler Gregory , Rubenstein Howard , Gamil Dawood , Akright Laura , Krawczyk Justine , Cobler Joanne , Wells Terry , Welker James , Foster Robert , Gilmore Richard , Anderson Jay , Jacoby Douglas , Harris Bill , Gardner Geraldine , Dandillaya Ramprasad , Vora Kishor , Kostis John , Hunter John , Laxson David , Ball Eric , Anderson Jay , Wells Terry , Vora Kishor , Ball Eric , Welker James , Lopes Renato D. , Egydio Flavia , Kawakami Anelise , Oliveira Janaina , Goodman Shaun G. , Wozniak Julianna , Matthews Alexander , Ratky Caroline , Valiris Janine , Berdan Lisa , Hepditch Anita , Quintero Kirby , Roe Matthew T. , Rorick Tyrus , Westbrook Melissa , Danchin Nicolas , Bezault Madeleine , Drouet Elodie , Simon Tabassome , White Harvey D. , Alsweiler Caroline , Sinnaeve Peter , Luyten Anne , Aylward Philip E , Butters Julie , Griffith Liddy , Shaw Michelle , Hagström Emil , Grunberg Lena , Szarek Michael , Islam Shahidul , Brégeault Marie-France , Bougon Nathalie , Faustino Douglas , Fontecave Sylvie , Murphy Judith , Tamby Jean- Francois , Verrier Melanie , Agnetti Veronique , Andersen Dorthe , Badreddine Emmy , Bekkouche Mhamed , Bouancheau Cecile , Brigui Imane , Brocklehurst Maddy , Cianciarulo Joseph , Devaul Dawn , Domokos Szilvia , Gache Cecile , Gobillot Caroline , Guillou Severine , Healy Jan , Heath Megan , Jaiwal Gayatri , Javierre Carine , Labeirie Julien , Monier Myriam , Morales Ulises , Mrabti Asmaa , Mthombeni Bicky , Okan Betim , Smith Lucile , Sheller Jennifer , Sopena Sebastien , Pellan Valerie , Benbernou Fadela , Bengrait Nafissa , Lamoureux Maud , Kralova Katarina , Scemama Michel , Bejuit Raphael , Coulange Anthony , Berthou Christelle , Repincay Jérôme , Lorenzato Christelle , Etienne Alexis , Gouet Valerie , Lecorps Guillaume , Loizeau Virginie , Normand Mickael , Ourliac Anne , Rondel Christelle , Adamo Antony , Beltran Pascale , Barraud Pauline , Dubois-Gache Helene , Halle Benjamin , Metwally Lamia , Mourgues Maxime , Sotty Marc , Vincendet Marion , Cotruta Raluca , Chengyue Zhu , Fournie-Lloret Dominique , Morrello Christine , Perthuis Aurelie , Picault Patrick , Zobouyan Isabelle , Colhoun Helen M. , Dempsey Michael A. , McClanahan Mark A. 
Published: August 2022

Background:

Apolipoprotein B (apoB) provides an integrated measure of atherogenic risk. Whether apoB levels and apoB lowering hold incremental predictive information on residual risk after acute coronary syndrome beyond that provided by low-density lipoprotein cholesterol is uncertain.

Methods:

The ODYSSEY OUTCOMES trial (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) compared the proprotein convertase subtilisin/kexin type 9 inhibitor alirocumab with placebo in 18 924 patients with recent acute coronary syndrome and elevated atherogenic lipoproteins despite optimized statin therapy. Primary outcome was major adverse cardiovascular events (MACE; coronary heart disease death, nonfatal myocardial infarction, fatal/nonfatal ischemic stroke, hospitalization for unstable angina). Associations between baseline apoB or apoB at 4 months and MACE were assessed in adjusted Cox proportional hazards and propensity score–matched models.

Results:

Median follow-up was 2.8 years. In proportional hazards analysis in the placebo group, MACE incidence increased across increasing baseline apoB strata (3.2 [95% CI, 2.9–3.6], 4.0 [95% CI, 3.6–4.5], and 5.5 [95% CI, 5.0–6.1] events per 100 patient-years in strata <75, 75–<90, ≥90 mg/dL, respectively;
P
trend
<0.0001) and after adjustment for low-density lipoprotein cholesterol (
P
trend
=0.035). Higher baseline apoB stratum was associated with greater relative (
P
trend
<0.0001) and absolute reduction in MACE with alirocumab versus placebo. In the alirocumab group, the incidence of MACE after month 4 decreased monotonically across decreasing achieved apoB strata (4.26 [95% CI, 3.78–4.79], 3.09 [95% CI, 2.69–3.54], and 2.41 [95% CI, 2.11–2.76] events per 100 patient-years in strata ≥50, >35–<50, and ≤35 mg/dL, respectively). Compared with propensity score–matched patients from the placebo group, treatment hazard ratios for alirocumab also decreased monotonically across achieved apoB strata. Achieved apoB was predictive of MACE after adjustment for achieved low-density lipoprotein cholesterol or non–high-density lipoprotein cholesterol but not vice versa.

Conclusions:

In patients with recent acute coronary syndrome and elevated atherogenic lipoproteins, MACE increased across baseline apoB strata. Alirocumab reduced MACE across all strata of baseline apoB, with larger absolute reductions in patients with higher baseline levels. Lower achieved apoB was associated with lower risk of MACE, even after accounting for achieved low-density lipoprotein cholesterol or non–high-density lipoprotein cholesterol, indicating that apoB provides incremental information. Achievement of apoB levels as low as ≤35 mg/dL may reduce lipoprotein-attributable residual risk after acute coronary syndrome.

Registration:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT01663402.