bluuebunny/crossref_metadata_2025 huggingface dataset:
Development of Sustained Release Baricitinib Loaded Lipid-Polymer Hybrid Nanoparticles with Improved Oral Bioavailability
Authors: Anwer Md. Khalid , Ali Essam A. , Iqbal Muzaffar , Ahmed Mohammed Muqtader , Aldawsari Mohammed F. , Saqr Ahmed Al , Ansari Mohd Nazam , Aboudzadeh M. Ali
Published: December 2021

Baricitinib (BTB) is an orally administered Janus kinase inhibitor, therapeutically used for the treatment of rheumatoid arthritis. Recently it has also been approved for the treatment of COVID-19 infection. In this study, four different BTB-loaded lipids (stearin)-polymer (Poly(d,l-lactide-co-glycolide)) hybrid nanoparticles (B-PLN1 to B-PLN4) were prepared by the single-step nanoprecipitation method. Next, they were characterised in terms of physicochemical properties such as particle size, zeta potential (ζP), polydispersity index (PDI), entrapment efficiency (EE) and drug loading (DL). Based on preliminary evaluation, the B-PLN4 was regarded as the optimised formulation with particle size (272 ± 7.6 nm), PDI (0.225), ζP (−36.5 ± 3.1 mV), %EE (71.6 ± 1.5%) and %DL (2.87 ± 0.42%). This formulation (B-PLN4) was further assessed concerning morphology, in vitro release, and in vivo pharmacokinetic studies in rats. The in vitro release profile exhibited a sustained release pattern well-fitted by the Korsmeyer–Peppas kinetic model (R2 = 0.879). The in vivo pharmacokinetic data showed an enhancement (2.92 times more) in bioavailability in comparison to the normal suspension of pure BTB. These data concluded that the formulated lipid-polymer hybrid nanoparticles could be a promising drug delivery option to enhance the bioavailability of BTB. Overall, this study provides a scientific basis for future studies on the entrapment efficiency of lipid-polymer hybrid systems as promising carriers for overcoming pharmacokinetic limitations.
Oral Cancer Theranostic Application of FeAu Bimetallic Nanoparticles Conjugated with MMP-1 Antibody
Authors: Tsai Meng-Tsan , Sun Ying-Sui , Keerthi Murugan , Panda Asit Kumar , Dhawan Udesh , Chang Yung-Hsiang , Lai Chih-Fang , Hsiao Michael , Wang Huey-Yuan , Chung Ren-Jei
Published: December 2021

Metastatic oral squamous cell carcinoma (SCC) displays a poor disease prognosis with a 5-year survival rate of 39%. Chemotherapy has emerged as the mainstream treatment against small clusters of cancer cells but poses more risks than benefits for metastatic cells due to the non-specificity and cytotoxicity. To overcome these obstacles, we conjugated antibodies specific for matrix metalloproteinase-1 (MMP-1), a prognostic biomarker of SCC, to iron–gold bimetallic nanoparticles (FeAu NPs) and explored the capability of this complex to target and limit SSC cell growth via magnetic field-induced hyperthermia. Our results showed that 4.32 ± 0.79 nm sized FeAu NPs were superparamagnetic in nature with a saturation magnetization (Ms) of 5.8 emu/g and elevated the media temperature to 45 °C, confirming the prospect to deliver hyperthermia. Furthermore, conjugation with MMP-1 antibodies resulted in a 3.07-fold higher uptake in HSC-3 (human tongue squamous cell carcinoma) cells as compared to L929 (fibroblast) cells, which translated to a 5-fold decrease in cell viability, confirming SCC targeting. Finally, upon magnetic stimulation, MMP-1-FeAu NPs conjugate triggered 89% HSC-3 cellular death, confirming the efficacy of antibody-conjugated nanoparticles in limiting SCC growth. The synergistic effect of biomarker-specific antibodies and magnetic nanoparticle-induced hyperthermia may open new doors towards SCC targeting for improved disease prognosis.
Controlling the Chemistry of Nanoclusters: From Atomic Precision to Controlled Assembly
Authors: Basu Srestha , Paul Anumita , Antoine Rodolphe
Published: December 2021

Metal nanoclusters have gained prominence in nanomaterials sciences, owing to their atomic precision, structural regularity, and unique chemical composition. Additionally, the ligands stabilizing the clusters provide great opportunities for linking the clusters in higher order dimensions, eventually leading to the formation of a repertoire of nanoarchitectures. This makes the chemistry of atomic clusters worth exploring. In this mini review, we aim to focus on the chemistry of nanoclusters. Firstly, we summarize the important strategies developed so far for the synthesis of atomic clusters. For each synthetic strategy, we highlight the chemistry governing the formation of nanoclusters. Next, we discuss the key techniques in the purification and separation of nanoclusters, as the chemical purity of clusters is deemed important for their further chemical processing. Thereafter which we provide an account of the chemical reactions of nanoclusters. Then, we summarize the chemical routes to the spatial organization of atomic clusters, highlighting the importance of assembly formation from an application point of view. Finally, we raise some fundamentally important questions with regard to the chemistry of atomic clusters, which, if addressed, may broaden the scope of research pertaining to atomic clusters.
Diamond-Based Electrodes for Detection of Metal Ions and Anions
Authors: Shellaiah Muthaiah , Sun Kien Wen
Published: December 2021

Diamond electrodes have long been a well-known candidate in electrochemical analyte detection. Nano- and micro-level modifications on the diamond electrodes can lead to diverse analytical applications. Doping of crystalline diamond allows the fabrication of suitable electrodes towards specific analyte monitoring. In particular, boron-doped diamond (BDD) electrodes have been reported for metal ions, anions, biomolecules, drugs, beverage hazards, pesticides, organic molecules, dyes, growth stimulant, etc., with exceptional performance in discriminations. Therefore, numerous reviews on the diamond electrode-based sensory utilities towards the specified analyte quantifications were published by many researchers. However, reviews on the nanodiamond-based electrodes for metal ions and anions are still not readily available nowadays. To advance the development of diamond electrodes towards the detection of diverse metal ions and anions, it is essential to provide clear and focused information on the diamond electrode synthesis, structure, and electrical properties. This review provides indispensable information on the diamond-based electrodes towards the determination of metal ions and anions.
Impact of COVID-19 Lockdown in Eating Disorders: A Multicentre Collaborative International Study
Authors: Baenas Isabel , Etxandi Mikel , Munguía Lucero , Granero Roser , Mestre-Bach Gemma , Sánchez Isabel , Ortega Emilio , Andreu Alba , Moize Violeta L. , Fernández-Real Jose-Manuel , Tinahones Francisco J. , Diéguez Carlos , Frühbeck Gema , Le Grange Daniel , Tchanturia Kate , Karwautz Andreas , Zeiler Michael , Imgart Hartmut , Zanko Annika , Favaro Angela , Claes Laurence , Shekriladze Ia , Serrano-Troncoso Eduardo , Cecilia-Costa Raquel , Rangil Teresa , Loran-Meler Maria Eulalia , Soriano-Pacheco José , Carceller-Sindreu Mar , Navarrete Rosa , Lozano Meritxell , Linares Raquel , Gudiol Carlota , Carratala Jordi , Plana Maria T. , Graell Montserrat , González-Parra David , Gómez-del Barrio José A. , Sepúlveda Ana R. , Sánchez-González Jéssica , Machado Paulo P. P. , Håkansson Anders , Túry Ferenc , Pászthy Bea , Stein Daniel , Papezová Hana , Gricova Jana , Bax Brigita , Borisenkov Mikhail F. , Popov Sergey V. , Gubin Denis G. , Petrov Ivan M. , Isakova Dilara , Mustafina Svetlana V. , Kim Youl-Ri , Nakazato Michiko , Godart Nathalie , van Voren Robert , Ilnytska Tetiana , Chen Jue , Rowlands Katie , Voderholzer Ulrich , Monteleone Alessio M. , Treasure Janet , Jiménez-Murcia Susana , Fernández-Aranda Fernando
Published: December 2021

Background. The COVID-19 lockdown has had a significant impact on mental health. Patients with eating disorders (ED) have been particularly vulnerable. Aims. (1) To explore changes in eating-related symptoms and general psychopathology during lockdown in patients with an ED from various European and Asian countries; and (2) to assess differences related to diagnostic ED subtypes, age, and geography. Methods. The sample comprised 829 participants, diagnosed with an ED according to DSM-5 criteria from specialized ED units in Europe and Asia. Participants were assessed using the COVID-19 Isolation Scale (CIES). Results. Patients with binge eating disorder (BED) experienced the highest impact on weight and ED symptoms in comparison with other ED subtypes during lockdown, whereas individuals with other specified feeding and eating disorders (OFSED) had greater deterioration in general psychological functioning than subjects with other ED subtypes. Finally, Asian and younger individuals appeared to be more resilient. Conclusions. The psychopathological changes in ED patients during the COVID-19 lockdown varied by cultural context and individual variation in age and ED diagnosis. Clinical services may need to target preventive measures and adapt therapeutic approaches for the most vulnerable patients.
Vitamin D Deficiency and Gestational Diabetes Mellitus in Relation to Body Mass Index
Authors: Agüero-Domenech Nuria , Jover Silvia , Sarrión Ana , Baranda Javier , Quesada-Rico José A. , Pereira-Expósito Avelino , Gil-Guillén Vicente , Cortés-Castell Ernesto , García-Teruel María J.
Published: December 2021

A relationship between vitamin D deficiency (VDD) and gestational diabetes mellitus (GDM) has been described. Considering that GDM prevalence depends on body mass index (BMI), our main objective was to determine if VDD is associated with GDM, independent of BMI. A cross-sectional study with 886 pregnant women was conducted in Elda (Spain) from September 2019 to June 2020. To assess the association, Poisson regression models with robust variance were used to estimate the prevalence ratio (PR). The observed GDM prevalence was 10.5%, while the VDD prevalence was 55.5%. In the crude model, both VDD and obesity were associated with GDM, but in the adjusted model, only VDD was statistically significant (PR = 1.635, p = 0.038). A secondary event analysis did not detect differences in VDD, but BMI yielded a higher frequency of births by cesarean section and newborns with a >90 percentile weight in the obesity group. In conclusion, VDD is associated with GDM, independent of BMI. Future longitudinal studies could provide information on causality.
Metabolic-Associated Fatty Liver Disease (MAFLD), Diabetes, and Cardiovascular Disease: Associations with Fructose Metabolism and Gut Microbiota
Authors: Drożdż Karolina , Nabrdalik Katarzyna , Hajzler Weronika , Kwiendacz Hanna , Gumprecht Janusz , Lip Gregory Y. H.
Published: December 2021

Non-alcoholic fatty liver disease (NAFLD) is an increasingly common condition associated with type 2 diabetes (T2DM) and cardiovascular disease (CVD). Since systemic metabolic dysfunction underlies NAFLD, the current nomenclature has been revised, and the term metabolic-associated fatty liver disease (MAFLD) has been proposed. The new definition emphasizes the bidirectional relationships and increases awareness in looking for fatty liver disease among patients with T2DM and CVD or its risk factors, as well as looking for these diseases among patients with NAFLD. The most recommended treatment method of NAFLD is lifestyle changes, including dietary fructose limitation, although other treatment methods of NAFLD have recently emerged and are being studied. Given the focus on the liver–gut axis targeting, bacteria may also be a future aim of NAFLD treatment given the microbiome signatures discriminating healthy individuals from those with NAFLD. In this review article, we will provide an overview of the associations of fructose consumption, gut microbiota, diabetes, and CVD in patients with NAFLD.
Dietary Intake in Early Pregnancy and Glycemia in Late Pregnancy among Women with Obesity
Authors: Garnæs Kirsti Krohn , Elvebakk Trude , Salvesen Øyvind , Stafne Signe Nilssen , Mørkved Siv , Salvesen Kjell Åsmund , Moholdt Trine
Published: December 2021

Women with obesity have increased risk for hyperglycemia during pregnancy, with negative health consequences for mother and child. We aimed to investigate adherence to nutritional recommendations in early pregnancy and to examine associations between early pregnancy dietary intake and late pregnancy glycemia among women with obesity. We included 120 women with pre-pregnancy body mass index (BMI) ≥30 kg/m2 who participated in one of two randomized controlled trials. The participants completed a food frequency questionnaire in early pregnancy (gestational weeks 12–22). Fasting and 120 min glucose tolerance after ingestion of 75 g glucose were assessed in late pregnancy (gestational weeks 32–37). About 90% of the participants reported early pregnancy diary intake within the recommendations. Average intakes of vitamin D, iron, and folate were below recommended levels. High intakes of dairy products and protein in early pregnancy were associated with lower fasting glucose in late pregnancy, whereas high intake of bread was associated with lower 120 min glucose. There were no clear associations between single dietary variables and gestational diabetes mellitus (GDM) diagnosis in late pregnancy. In conclusion, some early pregnancy dietary variables were associated with late pregnancy glycemia. Potential causality of these findings should be investigated in future studies.
Anthropometric Measurements, Sociodemographics, and Lifestyle Behaviors among Saudi Adolescents Living in Riyadh Relative to Sex and Activity Energy Expenditure: Findings from the Arab Teens Lifestyle Study 2 (ATLS-2)
Authors: Al-Hazzaa Hazzaa M. , Alothman Shaima A. , Alghannam Abdullah F. , Almasud Alaa A.
Published: December 2021

The aim of the study was to examine the anthropometric measurements, sociodemographics, and lifestyle behaviors among Saudi adolescents relative to sex and physical activity (PA). A random cross-sectional survey conducted on Saudi adolescents from secondary schools in Riyadh, using a multistage stratified cluster sampling technique. Measurements included demographics, weight, height, waist circumference, PA, sedentary behaviors (SB), sleep duration, and dietary habits using a validated questionnaire. A total of 1262 adolescents (16.4 ± 0.95 years; 52.4% males) were studied. Overweight/obesity was more than 40%. Physical inactivity among adolescents was 53%, which indicates some improvement over the past years, especially among females. More than 80% of adolescents had over three hours/day of screen time, with no significant sex differences. Insufficient sleep was highly prevalent with gender differences. A large proportion of the participants did not consume daily breakfast (65.7%), vegetables (73.2%), fruits (84.2%), or milk/dairy products (62.4%), whereas significant proportions of the adolescents consumed sugar-sweetened drinks, fast food, French fries/potato chips, cake/donuts, and chocolates/candy on at least three days or more per week. It was concluded that non-daily intake of breakfast and vegetables was significantly associated with lower PA. The updated information can aid in effectively planning and implementing promotional programs toward improving the lifestyle behaviors of Saudi adolescent.
Nutritional Therapy in Persons Suffering from Psoriasis
Authors: Garbicz Jagoda , Całyniuk Beata , Górski Michał , Buczkowska Marta , Piecuch Małgorzata , Kulik Aleksandra , Rozentryt Piotr
Published: December 2021

Psoriasis is a chronic inflammatory skin disease. Immunological, genetic, and environmental factors, including diet, play a part in the pathogenesis of psoriasis. Metabolic syndrome or its components are frequent co-morbidities in persons with psoriasis. A change of eating habits can improve the quality of life of patients by relieving skin lesions and by reducing the risk of other diseases. A low-energy diet is recommended for patients with excess body weight. Persons suffering from psoriasis should limit the intake of saturated fatty acids and replace them with polyunsaturated fatty acids from the omega-3 family, which have an anti-inflammatory effect. In diet therapy for persons with psoriasis, the introduction of antioxidants such as vitamin A, vitamin C, vitamin E, carotenoids, flavonoids, and selenium is extremely important. Vitamin D supplementation is also recommended. Some authors suggest that alternative diets have a positive effect on the course of psoriasis. These diets include: a gluten-free diet, a vegetarian diet, and a Mediterranean diet. Diet therapy for patients with psoriasis should also be tailored to pharmacological treatment. For instance, folic acid supplementation is introduced in persons taking methotrexate. The purpose of this paper is to discuss in detail the nutritional recommendations for persons with psoriasis.
In Vitro Antibacterial Susceptibility of Different Pathogens to Thirty Nano-Polyoxometalates
Authors: Bâlici Ștefana , Rusu Dan , Páll Emőke , Filip Miuța , Chirilă Flore , Nicula Gheorghe Zsolt , Vică Mihaela Laura , Ungur Rodica , Matei Horea Vladi , Fiț Nicodim Iosif
Published: December 2021

Due to their unique properties, nano-polyoxometalates (POMs) can be alternative chemotherapeutic agents instrumental in designing new antibiotics. In this research, we synthesized and characterized “smart” nanocompounds and validated their antibacterial effects in order to formulate and implement potential new drugs. We characterized thirty POMs in terms of antibacterial activity–structure relationship. The antibacterial effects of these compounds are directly dependent upon their structure and the type of bacterial strain tested. We identified three POMs that presented sound antibacterial activity against S. aureus, B. cereus, E. coli, S. enteritidis and P. aeruginosa strains. A newly synthesized compound K6[(VO)SiMo2W9O39]·11H2O (POM 7) presented antibacterial activity only against S. aureus (ATCC 6538P). Twelve POMs exerted antibacterial effects against both Gram-positive and Gram-negative strains. Only one POM (a cluster derivatized with organometallic fragments) exhibited a stronger effect compared to amoxicillin. New studies in terms of selectivity and specificity are required to clarify these extremely important aspects needed to be considered in drug design.
Combining Therapeutic Drug Monitoring and Pharmacokinetic Modelling Deconvolutes Physiological and Environmental Sources of Variability in Clozapine Exposure
Authors: Wills Kenneth H. , Behan Stephen J. , Nance Michael J. , Dawson Jessica L. , Polasek Thomas M. , Hopkins Ashley M. , van Dyk Madelé , Rowland Andrew
Published: December 2021

Background: Clozapine is a key antipsychotic drug for treatment-resistant schizophrenia but exhibits highly variable pharmacokinetics and a propensity for serious adverse effects. Currently, these challenges are addressed using therapeutic drug monitoring (TDM). This study primarily sought to (i) verify the importance of covariates identified in a prior clozapine population pharmacokinetic (popPK) model in the absence of environmental covariates using physiologically based pharmacokinetic (PBPK) modelling, and then to (ii) evaluate the performance of the popPK model as an adjunct or alternative to TDM-guided dosing in an active TDM population. Methods: A popPK model incorporating age, metabolic activity, sex, smoking status and weight was applied to predict clozapine trough concentrations (Cmin) in a PBPK-simulated population and an active TDM population comprising 142 patients dosed to steady state at Flinders Medical Centre in Adelaide, South Australia. Post hoc analyses were performed to deconvolute the impact of physiological and environmental covariates in the TDM population. Results: Analysis of PBPK simulations confirmed age, cytochrome P450 1A2 activity, sex and weight as physiological covariates associated with variability in clozapine Cmin (R2 = 0.7698; p = 0.0002). Prediction of clozapine Cmin using a popPK model based on these covariates accounted for <5% of inter-individual variability in the TDM population. Post hoc analyses confirmed that environmental covariates accounted for a greater proportion of the variability in clozapine Cmin in the TDM population. Conclusions: Variability in clozapine exposure was primarily driven by environmental covariates in an active TDM population. Pharmacokinetic modelling can be used as an adjunct to TDM to deconvolute sources of variability in clozapine exposure.
N-Alkylmorpholines: Potent Dermal and Transdermal Skin Permeation Enhancers
Authors: Dvořáková Kristýna , Štěpánek Petr , Kroupová Jiřina , Zbytovská Jarmila
Published: December 2021

Transdermal drug delivery is an attractive non-invasive method offering numerous advantages over the conventional routes of administration. The main obstacle to drug transport is, however, the powerful skin barrier that needs to be modulated, for example, by transdermal permeation enhancers. Unfortunately, there are still only a few enhancers showing optimum properties including low toxicity and reversibility of enhancing effects. For this reason, we investigated a series of new N-alkylmorpholines with various side chains as potential enhancers in an in vitro permeation study, using three model permeants (theophylline, indomethacin, diclofenac). Moreover, electrical impedance, transepidermal water loss, cellular toxicity and infrared spectroscopy measurements were applied to assess the effect of enhancers on skin integrity, reversibility, toxicity and enhancers’ mode of action, respectively. Our results showed a bell-shaped relationship between the enhancing activity and the hydrocarbon chain length of the N-alkylmorpholines, with the most efficient derivatives having 10–14 carbons for both transdermal and dermal delivery. These structures were even more potent than the unsaturated oleyl derivative. The best results were obtained for indomethacin, where particularly the C10-14 derivatives showed significantly stronger effects than the traditional enhancer Azone. Further experiments revealed reversibility in the enhancing effect, acceptable toxicity and a mode of action based predominantly on interactions with stratum corneum lipids.
Enhancing Phenolic Content of Medicinal Aromatic Plants Extracts-Biofunctional Foods Preparation
Authors: Ziagova Maria G. , Mavromatidou Charoula , Samiotis Georgios , Amanatidou Elisavet
Published: December 2021

In this study, the assessment of TPC and antioxidant activity enhancement of medicinal and aromatic plant (MAP) aqueous extracts using natural sweeteners or encapsulation materials was carried out. MAP extracts fortified with polyphenols were used to produce biofunctional chocolate bites. Honey or erythritol added to Melissa officinalis concentrated aqueous extracts exhibited TPC at 19.53 mg GAE/mL and 18.24 mg GAE/mL, respectively, and DPPH radical scavenging activity greater than 82%, comparing to its non-concentrated aqueous extract (3.74 mg GAE/mL and 72.9%, respectively). Honey added to MAP concentrated aqueous extract mixtures presented up to twofold higher TPC compared to M. officinalis concentrated aqueous extracts with honey. Chocolate bites with MAP concentrated aqueous extract mixtures and honey exhibited TPC and DPPH radical scavenging activity at 29.48 mg GAE/g chocolate and 93.7%, respectively. The addition of gum arabic or inulin in MAP concentrated aqueous extract mixtures increased the TPC up to 12-fold (40.37 mg GAE/mL and 34.14 mg GAE/mL, respectively) compared to its non-concentrated aqueous extracts (3.38 mg GAE/mL), whereas DPPH radical scavenging activity approached 99.5%. Honey incorporation as a sweetener and polyphenolic compound encapsulation in gum arabic can lead to the production of biofunctional foods with elevated cytoprotective action without compromising their organoleptic attributes.
Correction: Shoaib et al. Neuroprotective Effects of Dried Tubers of Aconitum napellus. Plants 2020, 9, 356
Authors: Shoaib Ambreen , Siddiqui Hefazat Hussain , Dixit Rakesh Kumar , Siddiqui Sahabjada , Deen Badrud , Khan Andleeb , Alrokayan Salman H. , Khan Haseeb A. , Ahmad Parvaiz
Published: December 2021

We are sorry to report that some images in Figure 1 reported in our recently published paper [...]
Metabolites Produced by Fungi against Fungal Phytopathogens: Review, Implementation and Perspectives
Authors: Rodrigo Sara , García-Latorre Carlos , Santamaria Oscar
Published: December 2021

Many fungi, especially endophytes, have been found to produce multiple benefits in their plant hosts, with many of these benefits associated with the protection of plants against fungal diseases. This fact could be used in the development of new bio-products that could gradually reduce the need for chemical fungicides, which have been associated with multiple health and environmental problems. However, the utilization of the living organism may present several issues, such as an inconsistency in the results obtained and more complicated management and application, as fungal species are highly influenced by environmental conditions, the type of relationship with the plant host and interaction with other microorganisms. These issues could be addressed by using the bioactive compounds produced by the fungus, in cases where they were responsible for positive effects, instead of the living organism. Multiple bioactive compounds produced by fungal species, especially endophytes, with antifungal properties have been previously reported in the literature. However, despite the large amount of these metabolites and their potential, extensive in-field application on a large scale has not yet been implemented. In the present review, the main aspects explaining this limited implementation are analyzed, and the present and future perspectives for its development are discussed.
Effect of Fibre Orientation on Impact Damage Resistance of S2/FM94 Glass Fibre Composites for Aerospace Applications: An Experimental Evaluation and Numerical Validation
Authors: Giasin Khaled , Dhakal Hom N. , Featheroson Carol A. , Pimenov Danil Yurievich , Lupton Colin , Jiang Chulin , Barouni Antigoni , Koklu Ugur
Published: December 2021

This study aims to investigate the influence of fibre orientation and varied incident energy levels on the impact-induced damage of S2/FM94, a kind of aerospace glass fibre epoxy/composite regularly used in aircraft components and often subjected to low-velocity impact loadings. Effects of varying parameters on the impact resistance behaviour and damage modes are evaluated experimentally and numerically. Laminates fabricated with four different fibre orientations 0/90/+45/−458s, 0/90/90/08s, +45/−4516s, and  032 were impacted using three energy levels. Experimental results showed that plates with unidirectional fibre orientation failed due to shear stresses, while no penetration occurred for the 0/90/90/08s and +45/−4516s plates due to the energy transfer back to the plate at the point of maximum displacement. The impact energy and resulting damage were modelled using Abaqus/Explicit. The Finite Element (FE) results could accurately predict the maximum impact load on the plates with an accuracy of 0.52% to 13%. The FE model was also able to predict the onset of damage initiation, evolution, and the subsequent reduction of the strength of the impacted laminates. The results obtained on the relationship of fibre geometry and varying incident impact energy on the impact damage modes can provide design guidance of S2/FM94 glass composites for aerospace applications where impact toughness is critical.
Effect of Pre-Injection on Combustion and Emission Characteristics of a Diesel Engine Fueled with Diesel/Methanol/n-Butanol Blended Fuel
Authors: Wang Zhiqiang , Li Lijun
Published: December 2021

In this study, the combustion and emission characteristics of a diesel/methanol/n-butanol blended fuel engine with different pre-injection timings and pre-injection mass ratios were investigated by a computational fluid dynamics (CFD) model. The CFD model was verified by the measured results and coupled with a simplified chemical kinetics mechanism. Firstly, the corresponding three-dimensional CFD model was established by CONVERGE software and the CHEKMIN program, and a chemical kinetic mechanism containing 359 reactions and 77 species was developed. Secondly, the combustion and emission characteristics of the diesel engine with different diesel/methanol/n-butanol blended fuels were analyzed and discussed. The results showed that increases in the pre-injection timing and the pre-injection mass ratio could increase cylinder pressure and cylinder temperature and decrease soot, HC, and CO emissions. At 100% load, the maximum cylinder pressures at the start of pre-injection timing from −15 °CA to −45 °CA, were 7.71, 9.46, 9.85, 9.912, and 9.95 MPa, respectively. The maximum cylinder pressures at pre-injection fuel mass ratios from 0.1 to 0.9 were 7.98, 9.10, 9.96, 10.52, and 11.16 MPa, respectively. At 50% load, with increases of the pre-injection timing and pre-injection fuel mass ratio, the soot emission decreased by 7.30%, 9.45%, 27.70%, 66.80%, 81.80% and 11.30%, 20.03%, 71.32%, 83.80%, 93.76%, respectively, and CO emissions were reduced by 5.77%, 12.31%, 22.73%, 53.59%, 63.22% and 8.29%, 43.97%, 53.59%, 58.86%, 61.18%, respectively. However, with increases of the pre-injection timing and pre-injection mass ratio, NOx emission increased. In addition, it was found that the optimal pre-injection timing and optimal pre-injection mass ratio should be −30 °CA and 0.5, respectively. Therefore, through this study we can better understand the potential interaction of relevant parameters and propose pre-injection solutions to improve combustion and emission characteristics.
Cognitive Science of Religion and Classical Theism: A Synthesis
Authors: McNabb Tyler Dalton , DeVito Michael
Published: December 2021

Launonen and Mullins argue that if Classical Theism is true, human cognition is likely not theism-tracking, at least, given what we know from cognitive science of religion. In this essay, we develop a model for how classical theists can make sense of the findings from cognitive science, without abandoning their Classical Theist commitments. We also provide an argument for how our model aligns well with the Christian doctrine of general revelation.
Deformation of the Crust and Upper Mantle beneath the North China Craton and Its Adjacent Areas Constrained by Rayleigh Wave Phase Velocity and Azimuthal Anisotropy
Authors: Xu Xiaoming , Zhang Dazhou , Huang Xiang , Cao Xiaoman
Published: December 2021

The North China Craton (NCC) has experienced strong tectonic deformation and lithospheric thinning since the Cenozoic. To better constrain the geodynamic processes and mechanisms of the lithospheric deformation, we used a linear damped least squares method to invert simultaneously Rayleigh wave phase velocity and azimuthal anisotropy at periods of 10–80 s with teleseismic data recorded by 388 permanent stations in the NCC and its adjacent areas. The results reveal that the anomalies of Rayleigh wave phase velocity and azimuthal anisotropy are in good agreement with the tectonic domains in the study area. Low-phase velocities appear in the rift grabens and sedimentary basins at short periods. A rotation pattern of the fast axis direction of the Rayleigh wave together with a distinct low-velocity anomaly occurs around the Datong volcano. A NW–SE trending azimuthal anisotropy and a low-velocity anomaly at periods of 60–80 s are observed subparallel to the Zhangbo fault zone. The whole lithosphere domain of the Ordos block shows a high-phase velocity and counterclockwise rotated fast axis. The northeastern margin of the Tibetan plateau is dominated by a low-velocity and coherent NW–SE fast axis direction. We infer that the subduction of the Paleo-Pacific plate and eastward material escape of the Tibetan plateau mainly contribute to the deformation of the crust and upper mantle in the NCC.
Study of Atomic Oxygen Airglow Intensities and Air Temperature near Mesopause Obtained by Ground-Based and Satellite Instruments above Baikal Natural Territory
Authors: Saunkin Andrei , Vasilyev Roman , Zorkaltseva Olga
Published: December 2021

The research studied the comparison of the night air temperatures and the atomic oxygen airglow intensities at the mesopause obtained with satellite and ground-based instruments. Satellite data used in this study were obtained with the SABER limb-scanning radiometer operating aboard the TIMED satellite. Data of ground-based monitoring were obtained using the KEO Scientific “Arinae” Fabry–Pérot interferometer adapted for aeronomic research. Since an interferometer detects parameters of the 557.7 nm line for the entire emission layer, it is not quite appropriate to perform a direct comparison between the upper atmospheric temperature obtained from ground-based observations and that from a satellite at a particular height. To compare temperatures correctly, the effective temperature must be calculated based on satellite data. The effective temperature is a height-averaged temperature profile with the weight factors equal to the 557.7 nm line intensity at relevant heights. The height profile of intensity of this natural green airglow of the upper atmosphere is calculated from the height profile of atomic oxygen concentration. Data on chemical composition and air temperature at the mesopause from SABER were used to calculate the profiles. The night intensity of the 557.7 nm emission obtained from satellite data in this way was in good accordance with the results of ground-based observations, but the temperatures were different. The reason for temperature discrepancy was assumed to lie in the incorrect position of the intensity maximum of the reconstructed emission layer. According to our calculations based on SABER data, the intensity peak was observed at the height of 94–95 km. By shifting it relative to the SABER temperature height profile, we re-calculated the effective temperatures and compared them with the interferometer data. The best coincidence between seasonal temperature variations obtained using the proposed method was achieved when the maximum of the reconstructed 557.7 nm intensity height profile was shifted to 97 km, but it could not eliminate minor local differences in temperature behavior.
Feature Comparison of Two Mesoscale Eddy Datasets Based on Satellite Altimeter Data
Authors: You Zhiwei , Liu Lingxiao , Bethel Brandon J. , Dong Changming
Published: December 2021

Although a variety of ocean mesoscale eddy datasets are available for researchers to study eddy properties throughout the global ocean, subtle differences in how these datasets are produced often lead to large differences between one another. This study compares the Global Ocean Mesoscale Eddy Atmospheric-Oceanic-Biological interaction Observational Dataset (GOMEAD) with the well-recognized Mesoscale Eddy Trajectory Atlas in four regions with strong eddy activity: the Northwest Pacific Subtropical Front (SF), Kuroshio Extension (KE), South China Sea (SCS), and California Coastal Current (CC), and assesses the relative advantages and disadvantages of each. It was identified that while there is a slight difference in the total number of eddies detected in each dataset, the frequency distribution of eddy radii presents a right-skewed normal distribution, tending towards larger radii eddies, and there are more short- than long-lived eddies. Interestingly, the total number of GOMEAD eddies is 8% smaller than in the META dataset and this is most likely caused by the GOMEAD dataset’s underestimation of total eddy numbers and lifespans due to their presence near islands, and the tendency to eliminate eddies from its database if their radii are too small to be adequately detected. By contrast, the META dataset, due to tracking jumps in detecting eddies, may misidentify two eddies as a single eddy, reducing total number of eddies detected. Additionally, because the META dataset is reliant on satellite observations of sea surface level anomalies (SLAs), when SLAs are weak, the META dataset struggles to detect eddies. The GOMEAD dataset, by contrast, is reliant on applying vector geometry to detect and track eddies, and thus, is largely insulated from this problem. Thus, although both datasets are excellent in detecting and characterizing eddies, users should use the GOMEAD dataset when the region of interest is far from islands or when SLAs are weak but use the META dataset if the region of interest is populated by islands, or if SLAs are intense.
Ultra-Violet Mie Lidar Observations of Particulates Vertical Profiles in Macao during a Record High Pollution Episode
Authors: Liu Qiaojun , Cheng Andrew Yuksun , Zhu Jianhua , Chang Sauwa , Tam Kinseng
Published: December 2021

Vertical profiles of particulates were measured in Macao by using a 355 nm Mie scattering lidar during a dust event. A high energy pulse laser was employed as the light source to detect the extinction coefficient in the atmosphere. The extinction profiles showed layers of high aerosol concentrations in good agreement with both back trajectory analysis and ground-based pollution measurements in Macao, which indicate that this lidar is very useful for monitoring extinction profiles during extreme high aerosol loading and low visibility atmospheric conditions when most low energy lidar system is inefficient. The results evidenced that correlations between PM2.5 and TSP varied with the intensity of dust storm and the PM2.5/PM10 ratio was small during dust episode, which indicated that aerosols were dominated by large particles. Furthermore, results of the dust event showed high aerosol concentrations at altitudes where the wind carried the dusty aerosols from northern China, covering Shanghai and the Taiwan Channel, to the Pearl River Delta Region. This research improved the understanding of the dust properties in Macao.
Every Picture Tells a Story: Parenting Advice Books Provide a Window on the Past
Authors: Atkinson V. Sue
Published: December 2021

This paper comprises a collection of illustrations, along with background information, analysis, and commentary, from “baby books”—advice books published in the United States for a parent audience from the 1890s to the 1980s. These publications, and especially their drawings and photos, provide a window on past child rearing practices and beliefs. The paper provides historical background on parenting behaviors such as toilet training and infant feeding, then traces changes over time through drawings and photos that appeared in parenting advice publications. These publications grew in popularity as changing work and family structures removed traditional sources of information for parents, and scientific information and expert guidance took their place. Publications from a variety of sources, but especially the U.S. Children’s Bureau, are explored. A finding of note is that images of babies and their families, which in earlier publications were entirely white and middle class, became more diverse over time. The author concludes that published parental advice from professionals made for a fascinating study, was ideologically driven, and often lacked a basis in empirical scientific knowledge of child development, and therefore asserts that parents may regard such advice conditionally.
Food Waste: Treatments, Environmental Impacts, Current and Potential Uses
Authors: Di Stefano Vita , Durazzo Alessandra , Lucarini Massimo
Published: December 2021

Food waste is a major environmental and social concern, and its impact will most likely increase as the population grows [...]
Three-Dimensional Printing Fashion Product Design with Emotional Durability Based on Korean Aesthetics
Authors: Kam Seonju
Published: December 2021

Given the potentially significant environmental impacts of fashion design, various design approaches are required to extend product lifespan. Digital design methods may play an essential role in reducing the environmental impact of products and production processes. In addition, a design approach inspired by nature, where humans have long lived, is valid for sustainable design innovation. The purpose of this study is to examine the aesthetics of Koreans, who prefer nature, and to find a sustainable fashion design approach by using it as a knowledge database. In this study, a parametric design methodology that can reflect knowledge-based data in the process of producing 3D printing sustainable fashion products, considering the emotional durability of consumers, was used. The study results are as follows. From the aesthetic point of view of Korea, sustainable design characteristics represent unique Korean folk art, resilience to nature, and simplicity that resembles nature. The properties of the form represented to “forms resembling nature”, “changeable forms”, “organic forms”, and “minimal forms”. Materials were “nature inspired textures”, “rustic natural materials”, and “regional materials”. Colors were “the colors of nature” and “indigenous colors”. The parametric controls variables used for 3D printing the fashion products were size, assembly style, and sustainable material. These control parameters were used to create designs according to the individual taste of users. In the 3D printing fashion product design process, pieces were printed in different shapes and sizes by controlling the parameters to create designs according to users’ tastes and Korean aesthetics. It was determined that this process could extend the lifespan of products, and that it is possible to modify sustainable fashion products according to personal taste by adjusting numerical values and extracting visual images based on knowledge of art and culture.
Environmental Behavior of Youth and Sustainable Development
Authors: Shutaleva Anna , Martyushev Nikita , Nikonova Zhanna , Savchenko Irina , Abramova Sofya , Lubimova Vladlena , Novgorodtseva Anastasia
Published: December 2021

The relationship between people and nature is one of the most important current issues of human survival. This circumstance makes it necessary to educate young people who are receptive to global challenges and ready to solve the urgent problems of our time. The purpose of the article is to analyze the experience of the environmental behavior of young people in the metropolis. The authors studied articles and monographs that contain Russian and international experience in the environmental behavior of citizens. The following factors determine people’s behavior: the cognitive capabilities of people who determine the understanding and perception of nature and the value-affective component that determines the attitude towards nature. The next task of the study is surveying young people through an online survey and its analysis. The research was realized in Ekaterinburg, the administrative center of the Sverdlovsk region (Russia). The study of the current ecological situation in Ekaterinburg made it possible to conclude that the environmental problem arises not only and not simply as a problem of environmental pollution and other negative influences of human economic activity. This problem grows into transforming the spontaneous impact of society on nature into a consciously, purposefully, systematically developing harmonious interaction with it. The study results showed that, from the point of view of the youth of Ekaterinburg, the city’s ecological situation is one of the most pressing problems. Despite minor improvements over the past 3–5 years, this problem has not lost relevance, and regional authorities and city residents should be responsible for its solution. Young people know environmental practices, but they often do not apply them systematically. Ecological behavior is encouraged and discussed among friends/acquaintances. The key factors influencing the formation of environmental behavior practices are the mass media and social networks. The most popular social network for obtaining information on ecological practices among young people is Instagram, and the key persons are bloggers. This study did not reveal the influence of the socio-demographic characteristics of young people on the application of eco-behavior practices, which may indicate the need for a survey of a larger sample.
Impacts of COVID-19 on the Food Supply Chain: A Case Study on Saudi Arabia
Authors: Alsuwailem Alhanouf Abdulrahman , Salem Emad , Saudagar Abdul Khader Jilani , AlTameem Abdullah , AlKhathami Mohammed , Khan Muhammad Badruddin , Hasanat Mozaherul Hoque Abul
Published: December 2021

The entire world is suffering from the post-COVID-19 crisis, and governments are facing problems concerning the provision of satisfactory food and services to their citizens through food supply chain systems. During pandemics, it is difficult to handle the demands of consumers, to overcome food production problems due to lockdowns, work with minimum manpower, follow import and export trade policies, and avoid transportation disruptions. This study aims to analyze the behavior of food imports in Saudi Arabia and how this pandemic and its resulting precautionary measures have affected the food supply chain. We performed a statistical analysis and extracted descriptive measures prior to applying hybrid statistical hypothesis tests to study the behavior of the food chain. The paired samples t-test was used to study differences while the independent samples t-test was used to study differences in means at the level of each item and country, followed by the comparison of means test in order to determine the difference and whether it is increasing or decreasing. According to the results, Saudi Arabia experienced significant effects on the number of items shipped and the countries that supplied these items. The paired samples t-test showed a change in the behavior of importing activities by—47% for items and countries. The independent t-test revealed that 24 item groups and 86 countries reflected significant differences in the mean between the two periods. However, the impact on 41 other countries was almost negligible. In addition, the comparison of means test found that 68% of item groups were significantly reduced and 24% were increased, while only 4% of the items remained the same. From a country perspective, 65% of countries showed a noticeable decrease and 16% a significant increase, while 19% remained the same.
Hotel Employees’ Voice Behavior: The Role of Paternalistic Leadership and Organizational Identification
Authors: Zhuang Wen-Long , Lee Chun-Han , Ma Chung-Liang
Published: December 2021

This study explores the effect of paternalistic leadership (moral leadership, benevolent leadership, and authoritarian leadership) on hotel employees’ voice behavior and the moderating role of organizational identification. This study samples employees of five-star hotels in northern, central, and southern Taiwan. Purposive sampling is used to distribute 450 questionnaires: 150 in northern Taiwan, 150 in central Taiwan, and 150 in southern Taiwan. The number of valid questionnaires was 359, and the effective questionnaire recovery rate was 79.78%. The analysis results indicate that (1) supervisors’ moral leadership negatively affects hotel employees’ voice behavior, (2) supervisors’ benevolent leadership positively affects hotel employees’ voice behavior, (3) supervisors’ authoritarian leadership negatively affects hotel employees’ voice behavior, (4) organizational identification moderates the relationship between moral leadership and voice behavior, (5) organizational identification moderates the relationship between benevolent leadership and voice behavior, and (6) organizational identification moderates the relationship between authoritarian leadership and voice behavior. This study also proposes managerial implications based on the analysis results. This research attempts to make contributions to the literatures of hospitality and tourism.