bluuebunny/crossref_metadata_2025 huggingface dataset:
LoVE4MUM Mobile App to Prevent Postpartum Depression: Protocol for a Pilot Randomized Controlled Trial (Preprint)
Authors: Kamarudin Siti Sabrina , Idris Idayu Badilla , Sharip Shalisah , Ahmad Norfazilah
Published: January 2025

BACKGROUND

Postpartum depression remains a significant concern, posing substantial challenges to maternal well-being, infant health, and the mother-infant bond, particularly in the face of barriers to traditional support and interventions. Previous studies have shown that mobile health (mHealth) interventions offer an accessible means to facilitate early detection and management of mental health issues while at the same time promoting preventive care.

OBJECTIVE

This study aims to evaluate the effectiveness of the Leveraging on Virtual Engagement for Maternal Understanding & Mood-enhancement (LoVE4MUM) mobile app, which was developed based on the principles of cognitive behavioral therapy and psychoeducation and serves as an intervention to prevent postpartum depression.

METHODS

This single-blinded, pilot randomized controlled trial includes 64 mothers recruited from the postnatal ward and randomized using a 1:1 ratio to receive either postpartum care (treatment as usual) or postpartum care (treatment as usual) plus the self-guided LoVE4MUM mobile app. The primary outcome is the effectiveness of the mobile app at improving postpartum depression. Secondary outcomes are changes in the mental health literacy score and negative automatic thoughts, which are collected using a self-reported questionnaire.

RESULTS

Patient recruitment began on September 1, 2024. As of January 1, 2025, recruitment was successfully completed, with a total of 72 participants enrolled: 36 in the intervention group and 36 in the control group . The final results are anticipated to be available by March 2025, and publication is expected by the end of 2025.

CONCLUSIONS

By examining the LoVE4MUM app alongside standard postpartum care, this pilot randomized controlled trial seeks to offer preliminary evidence on the potential of mHealth tools to improve maternal mental health as well as to reduce postpartum depression symptoms. The findings are expected to contribute to the future development of effective, accessible, and scalable interventions for mothers.

CLINICALTRIAL

ClinicalTrials.gov NCT06366035; https://clinicaltrials.gov/study/NCT06366035

INTERNATIONAL REGISTERED REPORT

PRR1-10.2196/63564
Usage of a Multipurpose mHealth App among Adults with Sickle Cell Disease (Preprint)
Authors: Cronin Robert M , Quaye Nives , Liu Xin , Landes Kristina , Crosby Lori E , Kassim Adetola A , DeBaun Michael R , Schnell Patrick M
Published: January 2025

BACKGROUND

While mobile health applications (mHealth apps) have been made for various diseases, including sickle cell disease (SCD), most focus on a single purpose. SCD is a chronic disease that requires knowledge of the disease, self-management, and adherence to treatment plans. While mHealth apps have been made with single features for SCD, there is limited understanding of using a mHealth app with a more comprehensive set of features that could engage adults with SCD depending on what features they prefer and need to engage and empower them in their disease.

OBJECTIVE

We evaluated the usage of a mHealth app with various features, including pain tracking, quizzes for patient-facing guidelines, pain and asthma action plans, and goal setting.

METHODS

Adults with SCD were enrolled at two sickle cell centers between 2018-2022 as part of a 6-month feasibility randomized controlled trial with participants completing surveys at baseline and 6 months. Participants were randomized into receiving either a mHealth app + booklet with patient-facing guidelines or a booklet with the guidelines alone. The mHealth app comprised web pages with patient-facing guideline material and a Research Electronic Data Capture (REDCap) project. The REDCap project included a personal profile, a pain tracker, goal setting, quizzes about the guidelines, and pain or asthma action plans. The REDCap project also included the ability to send daily text messages at a time they chose, which contained a message they could create and a link to their profile. Outcomes included SCD-specific knowledge and acute healthcare utilization (emergency room visits and hospitalizations). We evaluated the usage of these different features and relationships with baseline variables, each other, and study outcomes.

RESULTS

Approximately 75% (50 of 67) of the enrolled and randomized participants completed all the study components, and 100% (26 of 26) of the participants who were randomized to the mHealth app arm and completed the study used the mHealth app. Further, 15 (50%) participants used multiple features. Baseline sickle cell knowledge and female gender were associated with more usage of pain diary (p=0.04) and mission (p=0.046) features, respectively. While not significant, mission completion was associated with lower hospitalizations (p=0.063).

CONCLUSIONS

Adults with SCD engaged differently with a mHealth app with multiple features. As this study was not focused on one part of our app, engagement with features in this app was entirely patient-driven, which may demonstrate the expected real-world use of a mHealth app in this population. A multipurpose app can help engage participants in self-management strategies through different features and potentially improve outcomes.

CLINICALTRIAL

This clinical trial is registered on https://clinicaltrials.gov/ with study ID: NCT03629678.
Protocol for a Prospective, Mixed-methods Study of Perinatal Cannabis Use, Depression, and the Mother-child Dyad (Preprint)
Authors: Micalizzi Lauren , Howe Lindy , Battle Cynthia , Metrik Jane , Gunn Rachel L
Published: January 2025

BACKGROUND

Postpartum depression (PD) rates in the United States are among the highest globally, posing significant, long-term risks to mothers, children, and families. Concurrently, perinatal cannabis use (CU) is increasing and may exacerbate PD symptoms over time. While growing evidence links CU with PD, little is known about how CU influences immediate depression symptoms (e.g., negative affect) or trajectories across the perinatal period. Moreover, CU’s potential impact on mother-infant interaction quality could intensify its effects on PD.

OBJECTIVE

This study aims to evaluate the daily and longitudinal effects of CU on PD symptoms and mother-infant interactions. The primary aims are to: (1) examine the event-level and longitudinal impact of CU on PD symptoms; and (2) evaluate the impact of CU on mother-infant interactions and PD via multiple methods.

METHODS

Participants complete a baseline laboratory assessment during pregnancy, followed by a virtual assessment at 6 weeks postpartum and a laboratory visit at 6 months postpartum. Each assessment was accompanied by a two-week ecological momentary assessment (EMA) burst, for a total of three EMA bursts. Retention visits occurred during the second and third trimesters, with a post-delivery call conducted within two weeks of birth. Recruitment was community-based (e.g., social media, flyers), enrolling 20 participants.

RESULTS

This project received institutional review board approval on December 19, 2022, and was awarded funding on February 1, 2023. The recruitment goal of N = 20 participants was reached on September 4, 2024. Follow-up data collection is ongoing, with completion expected by October 2025 and initial results anticipated by April 2026. Recruitment challenges were encountered early in the study, leading to successful adaptations in recruitment and data collection protocols.

CONCLUSIONS

This pilot study demonstrates the feasibility of a mixed-methods design to investigate the daily and longitudinal impact of CU on PD and mother-infant interactions. By incorporating repeated measures across the prenatal and postpartum periods, this research provides critical insights into CU’s effects on PD during a high-risk period for maternal mental health. The findings will advance understanding of how CU influences both immediate depressive symptoms and long-term mental health trajectories in postpartum individuals.
Peculiarities of morphological changes in the lamina cribrosa in patients with myopia and options of drug influence on its state
Authors: Bezditko P.A. , Veselovskaya Z.F. , Gulida A.O. , Panchenko Iu.O. , Kovtun M.I.
Published: January 2025

The literature review substantiates the need to study the morphological changes in the lamina cribrosa in patients with myopia. The authors discuss the pathogenesis of axial myopia, namely, changes in the lamina cribrosa in pathological elongation of the anteroposterior axis of the eye. It is interesting to review the methods for the treatment and diagnosis of myopia, which remain extremely difficult tasks due to the lack of knowledge about most pathogenetic mechanisms of its development. The authors mention the commonly available and well-known spectra of treatment measures: conservative, surgical, laser methods of treatment and diagnosis of myopia, as well as modern drug regimens to control the progression of myopic changes. To date, there are quite a few studies on changes in the lamina cribrosa in glaucoma. However, research on the parameters of lamina cribrosa changes in myopia is rare in scientific literature. A modern approach to the diagnosis of changes in the lamina cribrosa will help clarify the mechanisms of visual impairment in these patients and will serve as the basis for the development of methods for the prevention and treatment of blindness in people suffering from myopia.
La televisión como plataforma de despliegue hacia la presidencia: análisis de casos
Authors: Crovi Druetta Delia , Toussaint Florence
Published: January 2025

El innegable avance de la digitalización en los medios de comunicación abarca tanto a los tradicionales analógicos como a los nuevos digitales, que en conjunto conforman un ecosistema que juega un papel fundamental en las sociedades actuales. Estas reflexiones destacan la importancia de la televisión en ese ecosistema cuando es utilizada como plataforma desde la cual se inician campañas políticas presidenciales. Por su relevancia en países occidentales, analizamos seis casos de presidentes en los cuales la televisión destacó como medio de despegue, ya que su alcance masivo les proporcionó presencia, reconocimiento y popularidad en la ciudadanía, factores que a la postre contribuyeron a su triunfo. Asimismo, se explica el impacto del modelo político económico neoliberal en la televisión, a partir del cual pasó a integrar importantes oligopolios internacionales mediáticos, sumándose a las narrativas multimedias que reflejan los intereses económicos e ideológicos de esos consorcios.
Strategi Rekrutmen Dan Seleksi Karyawan Dalam Meningkatkan Kualitas Sumber Daya Manusia
Authors: Nuzlaila Lila , Hakim Imamul , Amalia Rahmi
Published: January 2025

The purpose of this study is to determine the recruitment and selection strategies of employees at PT Sukses Mantap Sejahtera in improving the quality of Human Resources. This type of research is a qualitative descriptive study. Data collection uses interview, observation and documentation methods. Data analysis techniques use interactive data analysis models. Data validity techniques use source triangulation and technical triangulation. The results of the study showed that PT Sukses Mantap Sejahtera uses open and closed recruitment strategies with reference to the company's SOP. The PT Sukses Mantap Sejahtera selection strategy has three stages: work experience selection, written test selection, and interview test selection.
TANGGUNG JAWAB BADAN PERTANAHAN NASIONAL DALAM PENGESAHAN SERTIFIKAT GANDA DITINJAU DARI SIYASAH DUSTURIYAH (Studi Penelitian Kantor Wilayah Provinsi Aceh)
Authors: Basrul Gunadi  , Bukhari Ali  , Riza Afrian Mustaqim
Published: January 2025

Pendaftaran tanah di Indonesia bertujuan untuk memberikan kepastian hukum bagi pemegang hak sebidang tanah, sehingga pemegang sertifikat mempunyai tanda bukti hak yang kuat. Namun pada faktanya masih banyak yang terjadi permasalahan dalam penerbitan sertifikat hak atas tanah, yaitu permasalahan sertifikat dengan kepemilikan ganda yang diterbitkan oleh BPN, dimana satu bidang tanah dikuasai oleh dua pemilik yang berbeda. Metode penelitian yang digunakan metode penelitian kualitatif yang tergolong dalam penelitian lapangan (field research), yang bersifat deskriptif analisis yang bersumber dari data primer melalui wawancara dan data sekunder dengan mengadakan studi kepustakaan (library research) berupa peraturan, buku, dan karya ilmiah lainnya. Perumusan masalah dalam skripsi ini ialah pertama, bagaimana tanggung jawab Badan Pertanahan Nasional dalam pengesahan sertifikat ganda dan yang kedua, bagaimana pandangan siyasah dusturiyah terhadap pertanggungjawaban BPN dalam pengesahan sertifikat ganda. Dimana BPN menerbitkan sebuah sertifikat sebagai tanda bukti hak atas sebidang tanah akan tetapi mengalami kecacatan pada bagian status kepemilikan karena terdapat dua kepemilikan sertifikat dengan tanah yang sama. Pandangan siyasah dusturiyah mengenai pertanggungjawaban BPN terhadap sertifikat ganda bahwasanya Badan Pertanahan Nasional tidak bertanggungjawab atas sertifikat yang digandakan sementara islam menerangkan setiap manusia memiliki tanggung jawab terhadap dirinya, keluarga dan negara.
CONSTRUINDO CONCEITOS QUÍMICOS POR MEIO DA PRODUÇÃO DE QUEIJO NA EJA
Authors: Santos Geisiane Miguel dos , Amaral Fabiano Pereira do
Published: January 2025

Na Educação de Jovens e Adultos (EJA), os temas geradores são fundamentais para a promoção da aprendizagem significativa e para a construção de conhecimentos a partir da realidade dos estudantes. Nesse sentido, a pesquisa realizada propôs compreensão acerca do uso do tema gerador “produção de queijo” como ponto de melhoria no ensino e na aprendizagem de Química. O estudo foi feito inicialmente com 20 estudantes do primeiro ano do Ensino Médio da EJA, de uma escola estadual localizada no município de Itapuã do Oeste-RO. Foram realizados pré-teste e pós-teste para verificação de aprendizagem dos estudantes, sendo submetidos a uma análise qualitativa. A pesquisa evidenciou que a metodologia utilizada favoreceu a construção do aprendizado dos conteúdos, possibilitando o envolvimento e o interesse nas aulas. Os 17 estudantes que chegaram ao final da pesquisa participaram assiduamente, tiveram bom desempenho nas atividades e demonstraram interesse no decorrer de todas as etapas. Com os resultados encontrados, constatou que, por meio da utilização do tema gerador "produção de queijo", é possível abordar o conteúdo de Química de forma diversificada e atrelada ao cotidiano dos estudantes, a fim de alcançar uma melhor aprendizagem. Foram identificadas evidências de Alfabetização Científica, mudança na fala e na escrita de termos, evidenciando que a pesquisa favoreceu um ressignificado dos conteúdos científicos abordados, conforme dados analisados.
El uso de la inteligencia artificial dentro de la administración tributaria
Authors: Cozzo Villafañe Patricia Alejandra
Published: January 2025

El presente trabajo trata acerca de los avances las nuevas tecnologías de la comunicación e información. Los avances en la aplicación de estas nuevas tecnologías y el uso de la IA a diferentes procesos de la administración pública, centrándome en las administraciones tributarias y administración de justicia. El uso de los algoritmos para los procesos rutinarios y repetitivos en la administración tributaria y de justicia. Quo Vadis: hacia dónde vamos. Algoritmos predictivos y la libre discrecionalidad.
Las nuevas economías de criptomonedas frente al lavado de activos
Authors: Cozzo Villafañe Patricia Alejandra
Published: January 2025

En el presente trabajo trato acerca de las debilidades acerca del uso de las monedas virtuales frente al lavado de activos y la financiación al terrorismo. La posibilidad de regular las transacciones on line y la ley de extinción de dominio. Se tratan todas estas cuestiones ya que estas monedas son muy populares habida cuenta el rechazo actual en líneas generales y por la población más joven hacia los gobiernos y también contra la banca tradicional. Se debe a que existe desconfianza hacia lo tradicional. Esto es muy conflictivo ya que marca un cambio de época y nuevas formas de contratación lo que genera mucha incertidumbre y en ese aspecto se puede afirmar que se ven favorecidos los delincuentes transnacionales. Los cambios en las finanzas afectan a toda la sociedad y también al intercambio monetario. Existen muchos tipos de Criptomonedas pero la más conocida es el bitcoin y los diferentes tipos de uso que se le da a este tipo de activos. El método utilizado será inductivo para analizar los diferentes usos asignados en el mercado y la opinión de la misma como la reserva federal o el Banco Central de Europa y sus formas de regulación. Se puede afirmar que las Criptomonedas impactan ya que por medio de estos métodos se puede mover activos por todo el globo haciendo uso de técnicas innovadoras. No obstante lo cual el anonimato hace que se vea atractivo para aquel que no quiera ser fiscalizado por las autoridades lo que favorece la evasión de los tributos. Su utilización tiene beneficios ya que se abonan comisiones menores a las bancarias, contratos inteligentes también existen riesgos como la escasa protección de los derechos del consumidor, facilidad para el lavado de activos y ocultamiento de la trazabilidad para poder seguir las operaciones on line. Existen diferentes fases en el lavado de activos conforme la doctrina mexicana de Forbes o la Alemana de Bernasconi. En estos casos la utilización de estas monedas hace que se deba adaptar la metodología y sus diferentes fases que son la colocación-ocultación e introducción. Esta divisa es digital, convertible, no convertible y descentralizada. Al realizarse la ocultación de modo rápido hace difícil poder seguir su ruta .
Percepción de los profesionales contadores sobre el cambio tecnológico y la adopción de la inteligencia artificial en la contabilidad en los últimos 5 años
Authors: Montenegro Rodríguez Nury Esperanza , Castellanos Ramos Natalia Gissed
Published: January 2025

Este artículo destaca las importantes innovaciones que se han producido en el campo de la contabilidad debido a la introducción de tecnologías avanzadas. La contabilidad ya no se limita a notas escritas a mano y hojas de cálculo. En cambio, la tecnología ha mejorado la eficiencia y precisión de la gestión de datos financieros. Las herramientas de automatización y contabilidad basadas en la nube se han vuelto más comunes, lo que facilita la colaboración y el acceso en tiempo real a la información financiera. Además, los contadores ahora pueden realizar análisis de datos avanzados para descubrir tendencias y patrones previamente ocultos. También se han mejorado la seguridad y el cumplimiento de los datos. En pocas palabras, la transformación digital de la contabilidad ha catapultado al campo hacia un futuro más eficiente, preciso y estratégico. Desde esta perspectiva, el propósito de este artículo es analizar las percepciones de los expertos contables sobre los cambios tecnológicos y la introducción de la inteligencia artificial en la contabilidad durante los últimos cinco años.
Assessment of Some Culture Media for Optimum Growth and Sporulation of Bipolaris sorokiniana Causing Spot Blotch of Wheat
Authors: Hijam B. , Maharaja G. L. , Roy A. , Roy V. , Hembram S.
Published: January 2025

An experiment was conducted during January–June, 2022 at Department of Plant Pathology, Uttar Banga Krishi Viswavidyalaya for the evaluation of the different culture media on the growth of the fungus Bipolaris sorokiniana causing spot blotch disease in wheat. Five different growth media, viz., Potato Dextrose Agar (PDA), wheat seed extract+PDA (WSPDA), wheat leaf decoction+PDA (WLPDA), carrot juice extract+PDA (CPDA), and oatmeal agar (OMA), were used in the experiment. PDA supplemented with different plant extracts exhibited differential growth and sporulation patterns on B. sorokiniana. The maximum colony diameter of 8.09 mm at 9 days after inoculation demonstrated that the OMA provided the best growth conditions. Moreover, based on the Tukey HSD test, the AUGPC of OMA was found to be the highest (34.68±1.3 cm2) and significantly different from all the other media used in the study. The OMA was followed by the WLPDA, which had an AUGPC of 22.6±1.79 cm2. The fungus sporulated in all the media considered for the present study, with OMA recording the highest sporulation with 44×104 spores ml-1, followed by WLPDA with 41×104 spores ml-1. The lowest level of sporulation was seen in CPDA, with a concentration of 15×103 spores ml-1. Based on the aforementioned results, it can be inferred that oatmeal agar was the most suitable medium for the development and sporulation of B. sorokiniana, followed by a mixture of wheat leaf decoction and PDA. On the other hand, PDA alone and carrot juice PDA were shown to be the least suitable media.
La creatividad como innovación racional y diálogo crítico en el horizonte del sentido
Authors: Beltrán García Iver A.
Published: January 2025

Se estudia el fenómeno de la creatividad buscando desmarcarla de las formas de actividad irracionales, acríticas, hermenéuticamente pobres y monológicas. Los métodos utilizados son el análisis conceptual y la construcción teórica. Como principal resultado, se define la creatividad como innovación sustentada en la actividad de la memoria y la imaginación, que asume una racionalidad problematizadora y que se desenvuelve en el horizonte del sentido bajo la forma de un diálogo. Esta forma de concebir a la creatividad aporta referentes para evaluar su profundidad (la racionalidad crítica) y su alcance (la riqueza de sentido y su potencialidad dialógica).
El anhelo de la paz: dos mensajes, dos perspectivas
Authors: Navarro Campos Jorge Luis , Díaz Olguín Ramón
Published: January 2025

Editorial
Time for Fishery Biomass Recovery from Overfishing by Mathematical Solution of the Logistic Equation
Authors: Hodgson Bruce R.
Published: January 2025

The aim of this paper is to develop a methodology to estimate recovery times using a wide range of published Ecopath modeled overfished data-rich fisheries that had not recovered in the North Sea, Mediterranean, and South America shelves. Recovery times were estimated by biomass increase according to the Verhulst logistic equation mathematical solution, requiring the intrinsic rate of natural increase, r, and the carrying capacity for a fishery, KE, both derived from documented fishery biological process principles. The mathematical solution indicated recovery from <0.2KE may be possible, initially to the minimum overfished level, BOF, of 0.25, then recovered, BREC, 0.4 of the fishery carrying capacity. It was estimated recovery in about 5 to ≤10 years could be obtained with fishing mortalities at half the intrinsic rate of natural increase. Recovery may require fishery stakeholders to select various strategies for recovery, including potential limitations by phytoplankton production in the fishery area. The documented recoveries for fishery areas of the sardine Namibian shelf fishery and climate-related temperature changes and upwelling effects on biomass of the hake fishery in the northern North Sea and West of Scotland shelves are used as examples. The potential recovery of a data-limited fishery is also shown using the relationships derived from the biological processes of data-rich fisheries. Further research is suggested on how to estimate the biomass of data-limited fisheries for recovery from overfishing.
Colapso sísmico basado en energía para edificios aporticados de concreto armado equipados con amortiguadores viscosos, Lima 2024
Authors: Toledo Espinoza Vlacev
Published: January 2025

El estudio investiga el comportamiento de edificios de concreto armado con pórticos resistentes a momentos y equipados con amortiguadores, utilizando la energía potencial para monitorear numéricamente el inicio del colapso. Se emplean curvas IDA para obtener el índice de margen de colapso (IMC) como principal indicador del desempeño sísmico, siguiendo el enfoque del FEMA P695. Se analizaron varios pórticos representativos de edificios de tres, seis y nueve pisos, con diferentes niveles de amortiguamiento suplementario (ξV1 de 5%, 10%, 20%, 30% y 40%) y amortiguadores lineales y no lineales (α igual a 1.0, 0.7, 0.5 y 0.3). El enfoque de investigación fue cuantitativo y aplicado, con un diseño cuasiexperimental. Se evidenció que la capacidad de colapso de los edificios varía según las características del sistema estructural y las propiedades de los amortiguadores. En los edificios con amortiguadores, el IMC aumentó entre 1.08 y 2.46 veces en comparación con los prototipos sin amortiguadores. Un mayor amortiguamiento asegura un aumento en el IMC, aunque los amortiguadores no lineales no logran el mismo efecto. Se observó que el IMC tiene correlación con los indicadores de la variable dependiente, lo que permitió derivar ecuaciones para predecir el desempeño sísmico al colapso, considerando el amortiguamiento suplementario inicial, el exponente de velocidad y la masa.
Fitorremediación de atrazina presente en suelo: uso de Medicago sativa y Lolium multiflorum Lam
Authors:   , Jaime Flores Nataly
Published: January 2025

The recovery of agricultural soil contaminated with pesticides that are not regulated, such as atrazine, is a priority, both to compensate for environmental damage and to produce safe food. Therefore, in this research work, the biotechnological alternative was proposed as phytoremediation. This technique can be carried out on site since it does not require specialized personnel to carry it out, generates little waste and has great versatility to treat a high diversity of contaminants. A comparative analysis was carried out between two phytoremediation systems using native ryegrass and alfalfa seeds, another two native ryegrass and alfalfa seed systems were evaluated but with the addition of nutrients, as well as two soil controls without a plant. All the above with and without added nutrients. From the experiments carried out, it was determined that the greatest degradation of atrazine (ATZ) in soil was for the phytoremediation systems by native ryegrass with 66.14% and phytoremediation by alfalfa with the addition of nutrients with 58.60%. According to the results, it was observed that the addition of nutrients has a positive effect on plants, improving their physical characteristics, such as an increase in the length of stems with leaves and thickening of roots, in addition to prolonging their lifespan. Both species could accumulate ATZ in their leafy stems, however, the highest concentration occurred in native ryegrass with 22.86 mg kg-¹, compared to alfalfa with 21.31 mg kg-¹. Furthermore, in both species their phytostabilizing capacity increased due to the addition of nutrients, since the concentrations that the species accumulated in the roots were 25.79 mg kg-¹ for native ryegrass and 24.25 mg kg-¹ for alfalfa. This study represents a great contribution, since in addition to remediating contaminated soils, sustainable agriculture and food security are promoted.
Psychological Violence at Work: Problems in Applying the Law in Lithuania
Authors: Leščinskaitė Aistė
Published: January 2025

The recent Lithuanian Law of Labor Code of 28 July 20221 introduced into Lithuanian Labor Code the concept of “psychological violence.” The definitions of psychological violence under this law adopt quite a broad conception of the notion of psychological violence. The legislator has defined the scope where psychological violence is prohibited, as well as new ground for terminations of employment contract, and use of psychological violence. The recent amendments to the Labor Code also impose numerous obligations on employers to prevent psychological violence at work, which, together with the recommendations of the State Labor Inspectorate, have caused confusion not only in companies, institutions, and organizations, but also in the lives of their managers. The limited case law after the change in the legal framework shows that the legal framework is not working as it should and is not adequately interpreted to prevent psychological violence, and therefore deserves criticism.
Evaluating Data Science Tools: A Comparative Analysis of Platforms
Authors: Perţa Emanuelle I.
Published: January 2025

This study targets organizations in the data science domain seeking optimal platforms for their operations. It employs experimental research using the comparison method and mathematical modeling integrated into the Global Utility Method and TOPSIS Method. The aim is to create hierarchies of three prominent data science platforms: IBM Watson Studio, SAS – Advanced Analytics Software and Google Cloud AI Platform. The analysis was conducted using Microsoft Excel. Various comparison criteria are meticulously applied to ensure mathematical correctness and comprehensiveness. The Data Science Platforms Conclusions, drawn from individual case studies, indicate that different methods yield similar results due to algorithmic variations and data sensitivity. Minor changes were observed in hierarchy positions, attributed to coefficient importance and method sensitivity. There is a necessity for multiple platforms to meet diverse organizational needs. Continuous development and innovation are crucial in this evolving field, where user preferences and technological advancements drive platform suitability.
Effect of Vipoxin (V. amm. meridionalis) and its components on neuromuscular transmission
Authors: Goranova Yana , Stoykova Silviya , Samnaliev Ivan , Atanasov Vasil
Published: January 2025

Vipoxin is the main toxic component isolated from the venom of long-nosed viper Vipera ammodytes meridionalis, which population is widely distributed on the Bulgarian area. The neurotoxin consists of two subunits – unstable and toxic phospholipase A2 (PLA2) and non-toxic acidic component without enzymatic activity (Vipoxin’s acidic components, VAC). In the current study, the action of neurotoxic complex was examined by neurophysiological in vivo experimental model on anaesthetized rats. Vipoxin produces neuromuscular blockade in a dose-dependent manner with non-depolarizing post-junctional site of action. It was found that isolated PLA2 displays significantly lower blocking activity in comparison with Vipoxin when both have been applied in equimolar concentration. That implies the stabilizing role of VAC and its significance for the toxicity of the whole complex. The Vipoxin-induced neuromuscular blockade is completely reversed when antivenom is administrated.
Effects of long term antiepileptic therapy on serum trace element levels in epileptic children
Authors: Kakkar Ashish Kumar , Gulati Sheffali , Sarangi Sudhir Chandra , Gupta Yogendra Kumar
Published: January 2025

Conventional anticonvulsants including valproate (VPA) and phenytoin (PHT) have been shown to influence the trace element homeostasis in patients with epilepsy. Even though the newer agents such as levetiracetam (LEV) are considerebetter tolerability profile, given the lack of long-term data this confidence is somewhat guarded. In this study, we evaluated the trace element profiles of epileptic children receiving conventional agents i.e., PHT and VPA and newer agent – LEV and compared them with healthy controls. The study groups based on drug treatment were as follows: Group-I (n=35) children received PHT, Group-II (n=30) received VPA, Group-III (n=27) were treated with VPA plus LEV while Group-IV (n=28) included healthy children. Serum levels of zinc, copper, selenium, strontium, magnesium, manganese, and iron were estimated using inductively coupled plasma-atomic emission spectrometry (ICP-AES). As compared to healthy controls, monotherapy with phenytoin was associated with increased serum levels of copper (1568.8 vs. 1053.6 ng/ml; p=0.002) as well as strontium (37.0 vs. 30.7 ng/ml; p=0.014). On the contrary, epileptic children treated with valproate monotherapy had decreased serum selenium (67.0 vs. 84.7 ng/ml; p=0.02) and zinc (1010.5 vs. 1242.9 ng/ml; p=0.003) concentrations. However, in the valproate plus levetiracetam therapy group, no significant alterations in the trace element status were observed. Our findings suggest a potential association between treatment with PHT and VPA and trace element changes in children diagnosed with epilepsy. However, newer agent LEV when used with VPA was not associated with these alterations. Further prospective studies are warranted to confirm our findings and to assess the impact of drug treatment on trace element homeostasis in epileptic children.
Naltrexone improves immune functions and spatial memory of ovariectomized rats with alcohol intake
Authors: Varadinova Miroslava G. , Boyadjieva Nadka I.
Published: January 2025

Estrogen deficiency and excessive alcohol intake are associated with numerous adverse effects on immune functions and cognitive abilities. There is lots of evidence for the role of cytokines in the functions of the central nervous system like emotions, learning and memory. The aim of the present study was to investigate the effects of the opioid antagonist naltrexone on IFN-γ serum levels and spatial memory of ovariectomized (OVX) rats with repeated alcohol intake. Female Wistar rats (200–200 g) were ovariectomized and randomly divided in four groups: 1 – “control” (physiological solution 1 ml/100 g p.o. for 4 weeks after OVX); 2 – “alcohol” (ethanol 30%, 1 ml/100 g, p.o. for 4 weeks after OVX); 3 – “alcohol+naltrexone” (ethanol 30%, 1 ml/100 g, p.o. for 4 weeks after OVX and naltrexone 2.5 mg/kg, i.p. for 3 weeks after OVX); 4 – “naltrexone” (naltrexone 2.5 mg/kg, i.p. for 3 weeks after OVX). Our results suggested a correlation between IFN-γ levels and learning and memory abilities of the experimental rats. Moreover, we demonstrated that naltrexone reduced the adverse effects of OVX and excessive ethanol on IFN-γ levels and cognitive performance. Our data suggest that naltrexone may have beneficial therapeutic effects on immunodeficiency and emotional and intellectual deficits in women with estrogen insufficiency and excessive alcohol intake.
Sodium and potassium nitrite-induced developmental genotoxicity in Drosophila melanogaster – effects in larval immune and brain stem cells
Authors: Ghosh Swapan Kumar , Chatterjee Tridip , Chakravarty Amit , Basak Ashim Kumar
Published: January 2025

This present report reveals the important aspects of sodium and potassium nitrite-induced genotoxicity during the development of a model organism, Drosophila melanogaster. Dietary sodium nitrite at ≥20 mM concentration caused significant nuclear deformation of two important larval cells, namely hemocytes and neuroblasts, that play important roles in immunity as well as growth and metamorphosis of the fly. In contrast, potassium nitrite induced significant nuclear deformities only in hemocytes at 30 mM concentration. Due to the unavailability of any report regarding the developmental genotoxic effects of nitrite food preservatives in immune and neural stem cells, results of our study deserve special mention as these provide first evidences of genotoxicity in these cells of the developing Drosophila larvae by these food additives.
Raising Client Confidence in Consulting Work
Authors: Hall-Stead Stephanie
Published: January 2025

The following discussion will consider practices and processes that a client should adopt in order to raise their confidence in the value of consulting work they commission. The discussion will focus on key criteria to facilitate success, whilst recognising that these alone will not result in valuable consulting outputs. A defined client scope will first be considered before moving on to collaboration and resources, trust, consultant expertise and governance framework before concluding how these factors contribute to the delivery of a valuable consultancy project outcome.
Chemical and pharmacological characterization of vasopressin antagonists
Authors: Hajnal Kelemen , Ágota-Noémi Barta
Published: January 2025

Cardiovascular disease is the leading cause of death in developed countries worldwide. In acute decompensated heart failure, hyponatraemia is common, often correlating with the severity of heart failure. In hyponatraemia, there is an excess of body water, for which therapy involves reducing water intake and increasing renal (electrolyte-free) water excretion. To achieve the latter, a new pharmacotherapeutic group has been introduced; the aquatic vasopressin antagonists, known as ‘vaptans’ (such as tolvaptan, satavaptan, etc.), which block vasopressin-2 (V2) receptors in the renal tubules. They have a unique mechanism of action; they promote water excretion and without affecting the excretion of other electrolytes (e.g., sodium ions). Vaptans have been shown to be effective in reversing hyponatraemia, syndrome of inappropriate antidiuretic hormone secretion (SIADH), and in managing heart and liver failure. In this review, we describe the history, preparation, physicochemical properties, structure-activity relationships, and pharmacological properties, as well as mechanism of action of vasopressin antagonists.
Pharmacognosy and phytochemistry of Mespilus germanica L. (common medlar)
Authors: Puski Gabriella-Melinda , Varga Erzsébet
Published: January 2025

Medlar (Mespilus germanica) is an exotic plant native to Central Asia and the southern slopes of the Caucasus, which was introduced to Europe during the Roman Empire. In its native habitats, it exists in both wild and cultivated forms. The plant is distinguished by its large, bright green leaves, white flowers, and unique fruit, making it a popular ornamental choice in botanical gardens and parks throughout Western Europe. The flowers typically bloom from late May to early June, and the fruit, which resembles an apple or an elongated pear, is suitable for human consumption. In the Caucasus region, the leaves, fruit, and bark of the medlar plant play a significant role in traditional folk medicine. It is cultivated in Italy, the Balkans, and in the Dobruja region of Romania, where it also grows spontaneously in the wild. The fruit, which weighs between 20 and 60 grams, is commonly used to produce jam, wine, jelly, and juice. Additionally, the leaves, bark, and fruit of the plant are recognized for their rich content of bioactive substances. Since the 2000s, the medlar plant has attracted considerable interest from researchers, with ongoing investigations into its active compounds and pharmacological properties. This study aims to present a literature review, highlighting that both the leaves and fruit are abundant in polyphenols, flavonoids, organic acids, minerals, and vitamin C. In the near future, the medlar fruit may emerge as a valuable raw material for the food and pharmaceutical industries, with the active substances extracted from its fruit and leaves potentially serving as significant resources in pharmaceutical applications.
Global Skills and Abilities for Economic Fresh Graduates in Romania. Analysis of Employers’ Demand for Global Competences Through Online Ads
Authors: BUTUM Lavinia Cornelia , NICOLESCU Luminita
Published: January 2025

Literature recognizes that labour market presents particularities that lead to imperfection in the formation of the demand and supply of competences. Also, in late years, many companies have more and more cross - border operations and are looking for employees that have skills and abilities that give them the ability to perform in a globalized environment. Furthermore, studies conducted along the years showed that it is difficult for universities to have a clear projection regarding the demand for skills and abilities and for that reason, curricula are harder to keep up with the real trends registered on labour market. For that motive, a periodical analysis of labour market requirements is necessary for each profession and for different employment levels. Starting from these considerations, in this study, it is proposed to identify the skills and abilities demanded by employers through online ads for entry level higher education Economist vacancies in Romania. The methodology is based on a qualitative method: the content analysis of LinkedIn ads for entry level higher education Economist and the used instrument is the contingency matrix. For the present analysis, there were used 200 nonrepetitive ads recorded on LinkedIn Romania for junior higher education Economics, between February and July 2024. The results show that, in general, regardless of job main duties, employers want to recruit graduates that have specific skills and abilities which help them to perform and adapt to a diverse and internationalized work environment.
The Sustainability of PAYG Pension Schemes: A Comparative Analysis (1993–2023)
Authors: ROTSCHEDL Jiri , ČERMÁKOVÁ Klára , DICK Tizian , PAVELKA Tomáš
Published: January 2025

The most common policy response to pension account deficit appears to be increasing age of retirement. Many countries with PAYG pension schemes have been experiencing this bitter reality. This paper brings to evidence some parameters of PAYG pension schemes neglected in short political cycles, but important from the long-term perspectives. We use data from the Czech Republic and Germany, two economies close geographically and by population structure, yet different in pension schemes tradition and economic development. By a comparative analysis we show in detailed parameters that a balanced family policy combined with macroeconomic policies may allow keeping retirement age fixed in a sustainable PAYG pension scheme.
An Imperial Snapshot: Colonial Anxiety and Picture Postcards in Early c.20 Indonesia
Authors: TEGGIN Edward Owen , HANIFATI Khusnul
Published: January 2025

This article examines the concept of colonial anxiety through the prism of printed postcards sent from the colonial Dutch East Indies, now Indonesia, during the early twentieth century. The argument is that picture postcards featuring colonial images or scenes act as multimodal forms of communication, allowing the sender to promulgate colonial-imperial assumptions while sending an often-banal tourist message to friends and family back home. The study approaches the topic by examining the postcolonial exchange in terms of a symbolic structure through which the coloniser and the colonial society produce symbolic knowledge, through items such as picture postcards, to portray their authority and knowledge of the colonised other. This is contextualised with the Lacanian understanding of structural anxiety to demonstrate the slippage which occurs when symbolic knowledge breaks down. Finally, this article calls for a more inclusive debate on colonial anxiety, drawing attention to the relative lack of definition of the term and the tendency for certain former colonies, such as Indonesia, to be excluded from discussion in favour of the oft-used South Asian example.
The Concept of Reforming Military Justice System Specifically in the Termination of Investigations on the Regulation of Institutions and Authority of Military Police Investigations in Indonesia
Authors: Prasetyoandi Destri , Sulistiani Lies , Rusmiati Elis
Published: January 2025

Objective: Military Criminal Procedure Law (HAPMIL) (Law No 31 of 1997) on Military Justice was found to require legal reform to correlate with current legal developments.  The substance of this law should further adapt to evolving legal principles including the prompt resolution of cases and the realization of justice as well as legal benefits which were the objectives long desired in the scope of Military Justice in Indonesia.
 
Theoretical Framework: In this context, there have been no regulations allowing Military Police Investigators (POM) to terminate military case during the investigation stage, even when valid reasons for termination exist. Therefore, this study aimed to address the lack of authority granted to POM to terminate investigations which undermined the effectiveness of legal processes.
 
Method: The analysis further used a normative legal approach and concluded that empowering POM investigators with authority to terminate investigations would enhance the efficiency of law enforcement.
 
Results and Discussion: Specifically, when POM determined that an investigation lacked sufficient evidence to proceed terminating the process in accordance with legal provisions would ensure fairness and clarity for both the accused and investigators.
 
Research Implications: This study provides valuable insights for policymakers, agricultural practitioners, and stakeholders in Magetan Regency.
 
Originality/Value: This research offers a unique contribution to the existing literature on food security and land use planning. The findings of this study can be applied to other regions facing similar challenges, making it a valuable resource for researchers, policymakers, and practitioners.
Applicationof Full Factorial Planning to Control Nitrogen in a Water Resource
Authors: Sampaio Nilo Antônio de Souza , Siqueira Sílvio Sérgio Silveira de , Almeida Maria da Glória Diniz de , Mazza Felipe Cury , Miranda Junior João Ercio , Kawakani Mariana Leiko , Silva Gleiton Isaac do Nascimento da
Published: January 2025

Objective: The aim of this work is to show the application of Full Factorial Planning to an environmental problem.
 
Theoretical framework: Design of experiments is defined as a set of statistical techniques applied to the planning, conduct, analysis and interpretation of controlled tests, seeking to find (define) the factors that influence the values of a parameter or a group of parameters. Its basic principle makes it possible to vary all the levels of all the discrete or continuous variables (called factors) at once, for each experiment, in a programmed and rational way (Peixoto et al., 2008).
 
Method: Experiments were carried out in an industrial plant in the south of Rio de Janeiro and the data was treated using Full Factorial Design.
 
Final Considerations: It can be concluded that full factorial design is a very viable option for obtaining the optimum values or the optimum range of values to obtain the best possible response variable in a study. In this specific case of the company, it can be concluded that Line 1 and Line 3 are the most responsible for the concentration of nitrogen oxide discharged into the river and, therefore, the n-waste should be pre-treated.
 
Implications of the research: The use of Factorial Planning is multiplying in the scientific literature and is proving to be highly effective in dealing with data where the assumptions of Normality are not confirmed.
 
Originality/value: Despite being well-known statistical tools, Factorial Designs are widely used and can bring innovations to their application, as in the case of the company in question.