bluuebunny/crossref_metadata_2025 huggingface dataset:
The Lyman-limit photon mean free path at the end of late reionization in the Sherwood–Relics simulations
Authors: Feron Jennifer , Conaboy Luke , Bolton James S , Chapman Emma , Haehnelt Martin G , Keating Laura C , Kulkarni Girish , Puchwein Ewald
Published: July 2024

Recent evidence supporting reionization ending at redshift $z \lesssim 6$ includes the rapid redshift evolution of the mean free path, $\lambda _{\rm mfp}$, for Lyman-limit photons through the intergalactic medium (IGM) at $5\lt z\lt 6$. Here, we investigate $\lambda _{\rm mfp}$ predicted by the Sherwood–Relics suite of hybrid radiation hydrodynamical simulations. Simulations with comoving volumes of $40^{3}\, h^{-3}\rm \, cMpc^{3}$ ($160^{3}\, h^{-3}\rm \, cMpc^{3}$), calibrated to match the observed Ly $\alpha$ forest transmission with a late end to reionization at $z\lt 6$, are consistent with recent $\lambda _{\rm mfp}$ measurements at $z\lt 5.9$, and are $1.2\sigma$ ($1.8\sigma$) above the highest redshift $\lambda _{\rm mfp}$ measurement at $z=5.93$. The majority of the Lyman-limit opacity at the end of reionization is attributable to highly ionized Ly $\alpha$ forest absorbers with neutral hydrogen column densities $N_{\rm HI} \leq 10^{16}$–$10^{17}\rm \, cm^{-2}$. Resolving these systems is critical for capturing the redshift evolution of $\lambda _{\rm mfp}$ during the final stages of reionization. After reionization completes, overdense gas will reduce $\lambda _{\rm mfp}$ by up to 20 per cent around haloes with masses $M_{\rm h}\sim 10^{9}$–$10^{11}h^{-1}\, {\rm M}_{\odot }$, but during reionization ionized bubbles will instead boost $\lambda _{\rm mfp}$ around haloes by up to an order of magnitude when the IGM is as much as 90 per cent neutral by volume. This effect will play an important role in the visibility of Ly $\alpha$ emitting galaxies at $z\gtrsim 10$ discovered with JWST.
The Physalis system: discovery of ORC-like radio shells around a massive pair of interacting early-type galaxies with offset X-ray emission
Authors: Koribalski Bärbel S , Khabibullin Ildar , Dolag Klaus , Churazov Eugene , Norris Ray P , Carretti Ettore , Hopkins Andrew M , Vernstrom Tessa , Shabala Stanislav S , Gupta Nikhel
Published: July 2024

We present the discovery of large radio shells around a massive pair of interacting galaxies and extended diffuse X-ray emission within the shells. The radio data were obtained with the Australian Square Kilometre Array Pathfinder (ASKAP) in two frequency bands centred at 944 MHz and 1.4 GHz, respectively, while the X-ray data are from the XMM–Newton observatory. The host galaxy pair, which consists of the early-type galaxies ESO 184-G042 and LEDA 418116, is part of a loose group at a distance of only 75 Mpc (redshift $z = 0.017$). The observed outer radio shells (diameter ${\sim}$145 kpc) and ridge-like central emission of the system, ASKAP J1914−5433 (Physalis), are likely associated with merger shocks during the formation of the central galaxy (ESO 184-G042) and resemble the new class of odd radio circles (ORCs). This is supported by the brightest X-ray emission found offset from the centre of the Physalis system, instead centred at the less massive galaxy, LEDA 418116. The host galaxy pair is embedded in an irregular envelope of diffuse light, highlighting ongoing interactions. We complement our combined radio and X-ray study with high-resolution simulations of the circumgalactic medium (CGM) around galaxy mergers from the Magneticum project to analyse the evolutionary state of the Physalis system. We argue that ORCs/radio shells could be produced by a combination of energy release from the central active galactic nucleus and subsequent lightening up in radio emission by merger shocks travelling through the CGM of these systems.
Theorizing Musical Improvisation for Social Analysis
Authors: Martin Ryan
Published: July 2024

The connections between musical improvisation and society are a topic of frequent scholarly interest. These investigations take a range of analytical approaches, often adapted to the specifics of the improvised musicking being examined. This paper synthesizes existing concepts and theories to produce a framework for improvisation that is applicable to the social analysis of a wide range of improvisatory musical practices. The three foundational tenets of this framework are: (1) improvisation is one musical property among many that occurs to varying degrees and in different ways that fluctuate across space, time, and relevant actors; (2) the interactions between musical improvisation and the other properties of a given musical event are crucial for understanding its social implications; and (3) understanding these properties and their interactions requires examining the specific actions taken by improvisers in context. After outlining these tenets, the paper explores the role of various social, material, and individual factors in shaping improvisation and why examining these is crucial to social analysis. Finally, the paper demonstrates this model with a brief analysis of musical improvisation’s political impacts during the cacerolazos of the 2001–2002 Argentine Financial Crisis. The result of this paper is a theorization of improvisatory musicking especially suited to social analysis.
Glioma oncogenesis in the Constitutional mismatch repair deficiency (CMMRD) syndrome
Authors: Guerrini-Rousseau Lea , Merlevede Jane , Denizeau Philippe , Andreiuolo Felipe , Varlet Pascale , Puget Stéphanie , Beccaria Kevin , Blauwblomme Thomas , Cabaret Odile , Hamzaoui Nadim , Bourdeaut Franck , Faure-Conter Cécile , Muleris Martine , Colas Chrystelle , Adam de Beaumais Tiphaine , Castel David , Rouleau Etienne , Brugières Laurence , Grill Jacques , Debily Marie-Anne
Published: July 2024

Background

Constitutional mismatch repair deficiency (CMMRD) is a cancer predisposition due to biallelic mutations in one of the mismatch repair (MMR) genes associated with early onset of cancers, especially high-grade gliomas. Our aim was to decipher the molecular specificities of these gliomas.

Methods

Clinical, histopathological, and whole exome sequencing data were analyzed in 12 children with genetically proven CMMRD and a high-grade glioma.

Results

PDL1 expression was present in immunohistochemistry in 50% of the samples. In 9 patients, the glioma harbored an ultra-hypermutated phenotype (104–635 coding single nucleotide variants (SNV) per Mb, median 204). Driver mutations in POLE and POLD1 exonuclease domains were described for 8 and 1 patients respectively and were always present in the mutation burst with the highest variant allele frequency (VAF). The mutational signatures were dominated by MMR-related ones and similar in the different mutation bursts of a same patient without subsequent enrichment of the mutation signatures with POL-driven ones. Median number of coding SNV with VAF above one of the driving polymerase mutation per Mb was 57 (17–191). Our findings suggest that somatic polymerase alterations does not entirely explain the ultra-hypermutant phenotype. SETD2, TP53, NF1, EPHB2, PRKDC, and DICER1 genes were frequently mutated with higher VAF than the deleterious somatic polymerase mutation.

Conclusions

CMMRD-associated gliomas have a specific oncogenesis that does not involve usual pathways and mutations seen in sporadic pediatric or adult glioblastomas. Frequent alterations in other pathways such as MAPK may suggest the use of other targeted therapies along with PD1 inhibitors.
Comprehensive multimodal deep learning survival prediction enabled by a transformer architecture: A multicenter study in glioblastoma
Authors: Gomaa Ahmed , Huang Yixing , Hagag Amr , Schmitter Charlotte , Höfler Daniel , Weissmann Thomas , Breininger Katharina , Schmidt Manuel , Stritzelberger Jenny , Delev Daniel , Coras Roland , Dörfler Arnd , Schnell Oliver , Frey Benjamin , Gaipl Udo S , Semrau Sabine , Bert Christoph , Hau Peter , Fietkau Rainer , Putz Florian
Published: July 2024

Background

This research aims to improve glioblastoma survival prediction by integrating MR images, clinical, and molecular-pathologic data in a transformer-based deep learning model, addressing data heterogeneity and performance generalizability.

Methods

We propose and evaluate a transformer-based nonlinear and nonproportional survival prediction model. The model employs self-supervised learning techniques to effectively encode the high-dimensional MRI input for integration with nonimaging data using cross-attention. To demonstrate model generalizability, the model is assessed with the time-dependent concordance index (Cdt) in 2 training setups using 3 independent public test sets: UPenn-GBM, UCSF-PDGM, and Rio Hortega University Hospital (RHUH)-GBM, each comprising 378, 366, and 36 cases, respectively.

Results

The proposed transformer model achieved a promising performance for imaging as well as nonimaging data, effectively integrating both modalities for enhanced performance (UCSF-PDGM test-set, imaging Cdt 0.578, multimodal Cdt 0.672) while outperforming state-of-the-art late-fusion 3D-CNN-based models. Consistent performance was observed across the 3 independent multicenter test sets with Cdt values of 0.707 (UPenn-GBM, internal test set), 0.672 (UCSF-PDGM, first external test set), and 0.618 (RHUH-GBM, second external test set). The model achieved significant discrimination between patients with favorable and unfavorable survival for all 3 datasets (log-rank P 1.9 × 10−8, 9.7 × 10−3, and 1.2 × 10−2). Comparable results were obtained in the second setup using UCSF-PDGM for training/internal testing and UPenn-GBM and RHUH-GBM for external testing (Cdt 0.670, 0.638, and 0.621).

Conclusions

The proposed transformer-based survival prediction model integrates complementary information from diverse input modalities, contributing to improved glioblastoma survival prediction compared to state-of-the-art methods. Consistent performance was observed across institutions supporting model generalizability.
Sun-related knowledge and practices in Irish construction and agricultural workers
Authors: Hogan V , Hogan M , Kirwan O , Langan Walsh C , McLaughlin C , Moynihan Á , Connolly A , Walsh J , Coggins M
Published: July 2024

Background

Agricultural and construction workers spend much of their work time outdoors and have higher risks of developing skin cancer when compared to indoor workers. However, there is limited research on ultraviolet radiation (UVR) exposure knowledge, sun safety practices and constraints within these occupational groups in Ireland.

Aims

This study aimed to examine self-reported time spent outdoors in a sample of Irish agricultural and construction workers; to describe and compare UVR exposure knowledge, safety practices and perceived constraints in both occupational groups, and to assess the association of demographic, personal and occupational factors with sun-related knowledge, practices and perceived constraints.

Methods

Agricultural workers (n = 154) and construction workers (n = 467) completed a questionnaire, which measured solar UVR exposure knowledge, safety practices, and perceived constraints to sun personal protective equipment and sunscreen use in addition to demographic, personal, and workplace characteristics. Mann–Whitney and Kruskal–Wallis tests were used to examine differences in knowledge, practices and perceived constraints by these characteristics.

Results

Both groups spend a significant proportion of their working week outdoors (25 hours per week on average). Although participation in sun safety training was high for both groups, UVR exposure knowledge and sunscreen use were low, and annual rates of reported sunburn were high. Knowledge, practices and perceived constraints also differed significantly according to demographic, personal, occupational and workplace characteristics.

Conclusions

In addition to training by employers and advisory groups, interventions are required to address perceived barriers that impede the uptake and usage of control measures that can lower risk.
Positive correlation between Ammospiza caudacuta (Saltmarsh Sparrow) capture and productivity supports use of a novel rapid assessment monitoring protocol
Authors: Sanchez Arthur , Roeder Mackenzie R , Olsen Brian J , Elizondo Elisa C , Ruskin Katharine J , Hotopp Alice M , Elphick Chris S , Apgar Sam E , Field Christopher R , Cohen Jonathan B , Kocek Alison R , Kovach Adrienne I , Longenecker Rebecca A , Shriver W Gregory
Published: July 2024

Salt marshes in the northeastern United States provide critical breeding habitat for tidal marsh specialist birds like the Ammospiza caudacuta (Saltmarsh Sparrow). The Ammospiza caudacuta population declined by 9% annually from 1998 to 2012, necessitating immediate conservation actions for this vulnerable species. However, estimating species vital rates across a large geographic region is logistically challenging and cost prohibitive. Therefore, we developed and tested a rapid assessment monitoring protocol focused on reproductive metrics to enhance future conservation planning. We used 3 years (2018, 2019, and 2021) of intensive demographic data from 12 sites to estimate daily nest survival, nest period success, fledglings produced per female, and successful broods per female. We implemented the rapid assessment protocol co-located at intensive sites in the same years to estimate the number of captured females and juveniles. We used Pearson’s correlation analyses to determine the association of intensive metrics with rapid metrics. We found that the sum of Ammospiza caudacuta female and juvenile captures was positively correlated with daily nest survival (r = 0.61, P = 0.01), nest period success (r = 0.70, P = 0.002), fledglings produced per female (r = 0.82, P < 0.001), and successful broods per female (r = 0.82, P < 0.001). Our results demonstrate that fixed-effort mist-netting from our rapid assessment protocol is an informative and time-efficient sampling method that can aid in making informed management decisions related to Ammospiza caudacuta conservation.
Viromes of Antarctic fish resemble the diversity found at lower latitudes
Authors: Grimwood Rebecca M , Waller Stephanie J , Wierenga Janelle R , Lim Lauren , Dubrulle Jérémy , Holmes Edward C , Geoghegan Jemma L
Published: July 2024

Antarctica harbours some of the most isolated and extreme environments on Earth, concealing a largely unexplored and unique component of the global animal virosphere. To understand the diversity and evolutionary histories of viruses in these polar species, we determined the viromes of gill metatranscriptomes from 11 Antarctic fish species with 248 samples collected from the Ross Sea region spanning the Perciformes, Gadiformes, and Scorpaeniformes orders. The continent’s shift southward and cooling temperatures >20 million years ago led to a reduction in biodiversity and subsequent radiation of some marine fauna, such as the notothenioid fishes. Despite decreased host species richness in polar regions, we revealed a surprisingly complex virome diversity in Ross Sea fish, with the types and numbers of viruses per host species and individuals sampled comparable to that of fish in warmer marine environments with higher host community diversity. We also observed a higher number of closely related viruses likely representing instances of recent and historic host-switching events among the Perciformes (all notothenioids) than in the Gadiformes, suggesting that rapid speciation events within this order generated closely related host species with few genetic barriers to cross-species transmission. Additionally, we identified novel genomic variation in an arenavirus with a split nucleoprotein sequence containing a stable helical structure, indicating potential adaptation of viral proteins to extreme temperatures. These findings enhance our understanding of virus evolution and virus-host interactions in response to environmental shifts, especially in less diverse ecosystems that are more vulnerable to the impacts of anthropogenic and climate changes.
Origins, diversity, and adaptive evolution of DWV in the honey bees of the Azores: the impact of the invasive mite Varroa destructor
Authors: Lopes Ana R , Low Matthew , Martín-Hernández Raquel , Pinto M Alice , De Miranda Joachim R
Published: July 2024

Deformed wing virus (DWV) is a honey bee virus, whose emergence from relative obscurity is driven by the recent host-switch, adaptation, and global dispersal of the ectoparasitic mite Varroa destructor (a highly efficient vector of DWV) to reproduction on honey bees (Apis mellifera). Our study examines how varroa affects the continuing evolution of DWV, using the Azores archipelago, where varroa is present on only three out of the eight Islands, as a natural experimental system for comparing different evolutionary conditions and trajectories. We combined qPCR of 494 honey bee colonies sampled across the archipelago with amplicon deep sequencing to reveal how the DWV genetic landscape is altered by varroa. Two of the varroa-free Islands were also free of DWV, while a further two Islands were intriguingly dominated by the rare DWV-C major variant. The other four Islands, including the three varroa-infested Islands, were dominated by the common DWV-A and DWV-B variants. The varroa-infested Islands had, as expected, an elevated DWV prevalence relative to the uninfested Islands, but not elevated DWV loads, due the relatively high prevalence and loads of DWV-C on the varroa-free Islands. This establishes the Azores as a stable refuge for DWV-C and provides the most convincing evidence to date that at least some major strains of DWV may be capable of not just surviving, but actually thriving in honey bees in the absence of varroa-mediated transmission. We did not detect any change in DWV genetic diversity associated with island varroa status but did find a positive association of DWV diversity with virus load, irrespective of island varroa status.
Targeting HMGCS1 restores chemotherapy sensitivity in acute myeloid leukemia
Authors: Zhou Cheng , Li Jue , Sun Xiaofan , Zhao Liang , Zhan Huien , Liang Hui , Fang Peng , Zhang Tuo , He Qiongzhi , Du Juan , Zeng Hui
Published: July 2024

Acute myeloid leukemia (AML) is a common hematological malignancy with overall poor prognosis. Exploring novel targets is urgent and necessary to improve the clinical outcome of relapsed and refractory (RR) AML patients. Through clinical specimens, animal models and cell-level studies, we explored the specific mechanism of 3-hydroxy-3-methylglutaryl coenzyme A synthase 1 (HMGCS1) in AML and the mechanism of targeting HMGCS1 to attenuate cell proliferation, increase chemotherapy sensitivity and improve the occurrence and development of AML. Here, we reveal that HMGCS1 is overexpressed in RR patients and negatively related to overall survival (OS). Knocking out HMGCS1 in AML cells attenuated cell proliferation and increased chemotherapy sensitivity, while stable overexpression of HMGCS1 had the opposite effects. Mechanistically, we identified that knockout of HMGCS1 suppressed mitogen-activated protein kinase (MAPK) pathway activity, while overexpression of HMGCS1 could remarkably enhance the pathway. U0126, a MEK1 inhibitor, offset the effects of HMGCS1 overexpression, indicating that HMGCS1 promotes RR AML through the MAPK pathway. Further, we verified that hymeglusin, a specific inhibitor of HMGCS1, decreases cell growth both in AML cell lines and primary bone marrow cells of AML patients. Furthermore, combination of hymeglusin and the common chemotherapeutic drug cytarabine and adriamycin (ADR) had synergistic toxic effects on AML cells. Our study demonstrates the important role of HMGCS1 in AML, and targeting this protein is promising for the treatment of RR AML.
Triceps-to-Biceps Tendon Transfer Technique for Restoration of Elbow Flexion in Adult Brachial Plexus Injury
Authors: Weber Morgan B. , Townsley Sarah H. , Bishop Allen T. , Spinner Robert J. , Shin Alexander Y.
Published: July 2024

Restoration of elbow flexion is a priority in treating adult traumatic brachial plexus injuries. A tendon transfer is an ideal option for patients not candidates for reconstructive nerve surgery or free-functioning muscle transfer. For patients with a partial brachial plexus injury or a pan plexus injury with adequate recovered triceps function and loss of elbow flexion, a triceps-to-biceps tendon transfer is a nonmicrosurgical option to restore elbow flexion. The technique of triceps-to-biceps transfer in which the complete triceps tendon is transferred laterally, secured lateral to the radial tuberosity, and reinforced with suture to the biceps tendon is described.
CMV retinitis in non-HIV immunocompromised individuals on tofacitinib for rheumatoid arthritis
Authors: Smith Meghan J. , Lim Jennifer I. , Chau Felix Y. , Lobo-Chan Ann-Marie
Published: July 2024

Purpose:

To describe two patients with long-standing rheumatoid arthritis (RA) who developed cytomegalovirus (CMV) retinitis (CMVR) while taking tofacitinib.

Methods:

Retrospective case series.

Results:

A 79-year-old woman with RA, treated with oral tofacitinib 11mg once daily, presented with blurred vision and pain in the right eye. Visual acuity (VA) was hand motion, anterior segment showed iritis and the intraocular pressure (IOP) was 35mmHg. Ophthalmoscopy revealed retinal hemorrhages and overlying vitreous hemorrhage. HIV serology was negative, serum CMV IgG was positive and aqueous polymerase chain reaction (PCR) was positive for CMV (802,000 IU/mL). An 82-year-old woman with a history of RA, treated with tofacitinib 11mg once daily, was referred for a white retinal lesion in the left eye. VA was 20/50, anterior segment was quiet and IOP was 23mmHg. Ophthalmoscopy revealed a yellow retinal lesion with ill-defined margins in the macula. She subsequently developed a new area of peripheral retinal whitening in the right eye. HIV serology was negative, serum CMV IgG was positive and aqueous PCR was positive for CMV (5,200,000 IU/mL).

Conclusion:

Diagnosis of CMVR in non-HIV individuals requires awareness of the risk of infectious retinitis in patients taking JAK inhibitors for the treatment of autoimmune disease.
Prognostic significance of refractory thrombus in STEMI patients and the role of red cell distribution width: A case-control study
Authors: Guo Jianqi , Si Daoyuan , Yang Hongliang , Tong Yaliang , Fan Xingyu , Wei Jinghan , He Yuquan
Published: July 2024

The high thrombus burden of the infarct-related artery (IRA) is associated with the adverse prognosis in ST-segment elevation myocardial infarction (STEMI) patients. Our objectives were to investigate the predictors and evaluate the prognosis of refractory thrombus in STEMI patients. A total of 1305 consecutive patients with STEMI who underwent primary percutaneous coronary intervention (pPCI) were screened. The refractory thrombus group (n = 15) was defined as IRA thrombolysis in myocardial infarction flow < grade 2 after multiple thrombus aspiration (TA). The control group (n = 45) was age- and sex-matched and was selected from the same batch of patients. Baseline hematologic indices were measured before the pPCI. The major adverse cardiovascular events (MACE) were recorded during follow-up. The refractory thrombus group had significantly higher red cell distribution width (RDW) at baseline compared with the control group (13.1 [12.4–13.7] vs 12.6 [12.3–12.8], P = .008). In multivariate logistic regression analysis, RDW was an independent predictor of refractory thrombus (odds ratio: 8.799, 95% CI: 1.240–62.454, P = .030). The area under the receiver-operating characteristic curve of the RDW was 0.730 (95%CI: 0.548–0.912, P = .008). During a mean period of 26 months follow-up, patients in the refractory thrombus group tended to have higher percent MACEs compared with patients in the control group (53.3% vs 6.7%, P < .001). In the present study, we found that the refractory thrombus in STEMI patients was associated with the worse prognosis and the increased RDW might be a potential independent predictor.
Poor patients’ knowledge about venous thromboembolism and its therapy is associated with increased risk of major bleeding and discontinuation of anticoagulation: A cohort study
Authors: Gołąb Aleksandra , Plicner Dariusz , Konieczyńska Małgorzata , Broniatowska Elżbieta , Undas Anetta
Published: July 2024

It has been shown that patients’ knowledge about venous thromboembolism (VTE) and its therapy is suboptimal, which might reduce compliance and worsen prognosis. We investigated whether low VTE patients’ knowledge affects their clinical outcomes during long-term follow-up. We evaluated 151 consecutive patients (51.8 ± 15.7 years) after unprovoked VTE, who were recruited from the outpatient clinic (Krakow, Poland). All patients received anticoagulant treatment, mostly with direct oral anticoagulants (n = 113, 74.8%). The modified Jessa Atrial fibrillation Knowledge Questionnaire (JAKQ-VTE; 16 questions) was used to assess the knowledge of VTE and anticoagulant therapy. During a median follow-up of 58.0 months, VTE recurrence, major bleeding, and anticoagulation withdrawal were recorded. The median percentage of correct responses was 62.5% (12.5–100%) and was inversely correlated with age (P < .01). Diabetic patients and those with positive family history of VTE had lower overall scoring compared to the remainder (both P < .05). Major bleeding (n = 10, 6.6%) and anticoagulation withdrawal (n = 28, 18.5%), but not VTE recurrence (n = 12, 7.9%), were associated with lower overall scoring compared to the remainder (48.8% ± 12.5% vs 63.8% ± 16.3%, P = .003 and 55.3% ± 14.7% vs 64.4% ± 16.3%, P = .040, respectively). Major bleeding was independently associated with the female sex (hazard ratio [HR] 6.18; 95% confidence interval [CI] 1.15–33.19, P = .034), younger age (HR per 10 years 0.55; 95% CI 0.34–0.90, P = .016), OAC therapy discontinuation (HR 6.69; 95% CI 1.62–27.70), and lower overall scoring of JAKQ-VTE (HR 0.60 per 10 percentage points; 95% CI 0.40–0.92, P = .019). Insufficient knowledge about VTE and anticoagulant treatment predisposes to a higher risk of major bleeding and therapy discontinuation, but not VTE recurrence in unprovoked VTE patients during long-term follow-up.
Efficacy of intravenous acetaminophen on postoperative shivering: A meta-analysis of randomized controlled trials
Authors: Liu Jikai , Cao Qian , Zeng Jinfang , Liang Xiao
Published: July 2024

Purpose:

Postoperative shivering (POS) is a common and vital complication after anesthesia, which may result in serious consequences and uncomfortable experiences. Acetaminophen has been used to treat fever and mild to moderate pain. However, there is not enough evidence to prove its advantage for POS. This meta-analysis aimed to explore the prophylactic use of acetaminophen as a valid agent for POS.

Methods:

Two researchers independently searched PubMed, the Cochrane Library, and Embase for controlled clinical trials. The meta-analysis of randomized controlled trials (RCTs) was performed by Review Manager.

Results:

Nine trials with 856 patients were included in our meta-analysis. Acetaminophen significantly reduced POS compared with placebo (pooled risk ratio [RR]: 0.43, 95% confidence interval [CI]: 0.35–0.52). What is more, not only 15 mg/kg but also 1000 mg intravenous acetaminophen could reduce the incidence of shivering compared with placebo.

Conclusion:

Our present meta-analysis demonstrates that the intravenous prophylactic infusion of acetaminophen may prevent POS, and the results may provide new evidence to expand the clinical value of acetaminophen in addition to its routine usage.
Dietary management of gestational diabetes: A review
Authors: Long Bin-Yang , Liang Xin
Published: July 2024

Gestational diabetes mellitus (GDM) is a common condition in pregnant women that can affect the health of both the mother and the fetus. A healthy diet reduces the risk of GDM, while on the contrary, an unhealthy diet can increase the risk of developing GDM. Dietary interventions remain an important way to control GDM at this time. However, real-life diets are complex and varied, and the effect of these diets on gestational diabetes is unknown. This article summarizes research related to dietary control of GDM. Hopefully, this will help with dietary interventions for people with GDM.
Quality of life and physical activity levels among colorectal cancer patients: An observational study
Authors: Bayyat Manal M. , Amarin Rula , AlDabbas Hamdi , Akkawi Mohammad
Published: July 2024

This study investigated the influence of physical activity on the quality of life of patients with postsurgical colorectal cancer in Jordan. A total of 108 colorectal cancer patients aged ≥18 years who underwent surgery at the King Hussein Cancer Center participated voluntarily. The exclusion criteria were severe comorbidities, absolute contraindications to physical activity, and concurrent cancers. Data collection involved phone interviews using The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire and the Godin Leisure Time Exercise Questionnaire due to coronavirus disease 2019 restrictions. Significant positive differences in the quality of life subcategory “physical score” were observed between active and less active patients, favoring the active group. However, no significant differences were found in the impact of physical roles on quality of life between active and less active patients. Participation in physical activity is associated with enhanced physical function in both active and less active colorectal cancer patients. We recommend the implementation of physical activity programs and clinics at King Hussein Cancer Center. Future experimental studies assessing the impact of tailored physical activity training on quality of life are warranted.
Effects of common eye diseases in children and their treatment measures on ocular surface homeostasis: A review
Authors: Lv Zongyue , Tao Zhengyang , He Jing , Wang Jiao , Lin Zhihong , Kang Zefeng , Deng Hongwei
Published: July 2024

Ocular surface homeostasis plays a vital role in maintaining of eye health. Dry eye disease is one of the prominent and typical manifestations of disruption of ocular surface homeostasis that leads to the worsening of ocular surface homeostasis that leads to the worsening of ocular surface disease when it interacts with other pathogenic factors. However, disruption in ocular surface homeostasis in children is often overlooked because of the current methods of assessing ocular surface homeostasis. This review summarizes the main factors affecting ocular surface homeostasis in children, with the aim of drawing the attention of clinicians to the disruption of ocular surface homeostasis in children when dealing with such diseases. Ocular surface homeostasis involves several interrelated components, each of which plays a nonnegligible role in ocular surface homeostasis. Unlike adults, children have a stronger lacrimal gland secretion capacity and milder symptoms when there is a slight disruption of the ocular surface homeostasis. In addition, children’s expressive abilities were weaker. Therefore, dry eye in children is often ignored by doctors and parents, and clinicians should pay more attention to the protection of ocular surface homeostasis when treating children with these diseases. Therefore, there is a need for diagnostic criteria for dry eye disease specific to children.
Ichthyosis uteri complicated by endometrial adenocarcinoma with transitional cell differentiation: A case report
Authors: Ding Liya , Liu Wangwang , Li Hui , Huang Dingpin , Chen Yang , An Huimin
Published: July 2024

Rationale:

Ichthyosis uteri is a rare pathological condition characterized by the replacement of the endometrial lining by stratified squamous epithelium. Yet its occurrence with endometrial adenocarcinoma is very rare.

Patient concerns:

A 68-year-old woman has been experiencing sporadic, minor vaginal hemorrhages for a few months. The gynecological evaluation revealed a uterine enlargement and imaging demonstrated an irregular mass within the uterus.

Diagnosis:

Endometrial adenocarcinoma with transitional cell differentiation; ichthyosis uteri with dysplasia.

Interventions:

Radical hysterectomy with pelvic lymphadenectomy was performed followed by postoperative radiotherapy.

Outcomes:

Postoperative follow-up at 8 months showed a favorable outcome without signs of recurrence and metastasis.

Lessons:

Adequate pathological sampling is crucial to identifying the accompanying lesions of ichthyosis uteri. Finding molecular alterations in various pathological morphologies is important to understand the evolution of disease.
Unexpected rare uterine carcinosarcoma with neuroendocrine differentiation: Reflections on clinical diagnosis and treatment of a case report
Authors: Shi Qichong , Wang Longmei , Yao Juan
Published: July 2024

Rationale:

Uterine carcinosarcoma (UCS) is a rare and highly invasive malignant tumor.It exhibits an ectopic growth pattern of the uterus,and its histological features are biphasic differentiation of malignant epithelial components (cancer) and malignant mesenchymal components (sarcoma). The pathological pattern of high-component neuroendocrine differentiation is extremely rare. Due to the inherent heterogeneity of tumors, it increases the difficulty of accurate identification and diagnosis. The author introduces a rare case of primary endometrial carcinosarcoma (heterologous) with small cell neuroendocrine carcinoma (SCNEC) components. There is limited literature on this rare pathological differentiation pattern and a lack of guidelines for the best treatment methods, which prompts reflection on the diagnosis, optimal treatment strategies, and how preoperative diagnosis can affect patient prognosis for endometrial carcinosarcoma with neuroendocrine differentiation.

Patient concerns:

The patient is an elderly woman who presents with abnormal vaginal bleeding after menopause. Transvaginal ultrasound examination shows that the uterus is slightly enlarged, and there is a lack of homogeneous echogenicity in the uterine cavity. Subsequently, a hysteroscopic curettage was performed, and a space-occupying lesion was observed on the anterior wall of the uterine cavity.

Diagnoses:

Preoperative endometrial biopsy revealed SCNEC of the endometrium. The patient underwent radical hysterectomy, and the postoperative pathological results showed that UCS (heterologous) was accompanied by SCNEC components (about 80%).

Intervention:

The patient received radical hysterectomy, followed by adjuvant chemotherapy.

Outcome:

After 7 months of follow-up, no tumor recurrence or metastasis was found at the time of writing this article.

Lessons:

The histological type of UCS (heterologous) with cell neuroendocrine carcinoma components is rare and highly invasive, with a high misdiagnosis rate in preoperative biopsy. There are currently no effective treatment guidelines for this type of case. The unusual appearance of SCNEC components in this case poses a challenge for both pathologists and surgeon. The rare differentiation pattern of this case exposes the complexity of its management and the necessity of prospective trials to determine the optimal treatment plan.
Prevalence, and types of overuse injuries in gym centers: A cross-sectional study in Saudi Arabia
Authors: Hetaimish Bandar , Ahmed Hassan , Otayn Abdullah , Alzahrani Ahmed M. , Almasoudi Eid , Elaiw Mohammed , Alzwaihri Abubakr S. , Samargandi Ramy
Published: July 2024

Physical activity has numerous health benefits, enhancing overall wellbeing. However, it can also lead to injuries, impeding exercise capacity and hindering work. Limited knowledge exists about the prevalence of overuse gym injuries and whether they vary across different gym activities. This study aims to estimate sport injuries at fitness centers in Saudi Arabia, comparing injuries between various activities and session durations. This is a cross-sectional, questionnaire-based study surveyed regular gym-goers in Saudi Arabia with overuse injuries. The online survey, distributed through social media apps, collected data using a validated Google form questionnaire. Questioanire consists of 3 parts. First part of the questionnaire included demographic characteristics of participants. Second part contains characteristics related to gym as gym session’s duration, frequency of attending gym per week, sport types, type of injuries and site of injuries. Third part contains Oslo Sports Trauma Research Centre (OSTRC) Overuse injury questionnaire that included 4 questions about difficulties in participation, reduction of training, affection of performance and symptoms. Study included 1012 participants, majority male (76.2%), with age range of 18 to 50 years, and significant proportion falling between 26 and 30 years (52.6%). Majority of participants were from Central Province (42.9%). Gym sessions typically lasted 1 to 2 hours (68.3%), and most common attendance frequency was 4 days/week (39.6%). Common injury sites were shoulder (25.2%), knee (20.2%), and lower back (17.7%). Bodybuilding (50.6%), running (45.8%), and weightlifting/powerlifting (45.1%) were predominant sports. Strain/muscle rupture/tear (35.70%) and muscle cramps/spasm (19.3%) were commonest injury types. Longer gym sessions (>2 hours) were associated with higher prevalence of strain/muscle rupture/tear, dislocation, and subluxation (P < .001). Shorter sessions (<1 hour) had higher prevalence of muscle cramps/spasm and contusion/hematoma/bruise (P < .001). Gym sessions lasting 1 to 2 hours had high prevalence in tendinosis/tendinopathy. Strain/muscle rupture/tear was significantly higher in bodybuilding, weightlifting/powerlifting, swimming, cycling, and running. Tendinosis/tendinopathy was higher in crossfit. (OSTRC) Overuse injury questionnaire revealed decreased participation, training volume, performance, and increased pain with longer gym sessions. In conclusion, gym-related injuries are common, with bodybuilding and running being prevalent activities. Preventative measures should be taken, and individuals are advised to undergo a physical and medical examination before engaging in physical activity at fitness centers.
Utility of Second-look Ultrasonography in Distinguishing BI-RADS 4 Calcifications Detected on Mammography: An observational study
Authors: Cheng Sheng , Zhu Lin , Lin Ning , He Muzhen , Yu Yingbin , Lin Mengbo , Zhang Hui
Published: July 2024

This study aimed to assess the utility of second-look ultrasonography (US) in differentiating breast imaging reporting and data system (BI-RADS) 4 calcifications initially detected on mammography (MG). BI-RADS 4 calcifications have a wide range of positive predictive values. We hypothesized that second-look US would help distinguish BI-RADS 4 calcifications without clinical manifestations and other abnormalities on MG. This study included 1622 pure BI-RADS 4 calcifications in 1510 women (112 patients with bilateral calcifications). The cases were randomly divided into training (85%) and testing (15%) datasets. Two nomograms were developed to differentiate BI-RADS 4 calcifications in the training dataset: the MG-US nomogram, based on multifactorial logistic regression and incorporated clinical information, MG, and second-look US characteristics, and the MG nomogram, based on clinical information and mammographic characteristics. Calibration of the MG-US nomogram was performed using calibration curves. The discriminative ability and clinical utility of both nomograms were compared using the area under the receiver operating characteristic curve (AUC) and the decision analysis curve (DCA) in the test dataset. The clinical information and imaging characteristics were comparable between the training and test datasets. The bias-corrected calibration curves of the MG-US nomogram closely approximate the ideal line for both datasets. In the test dataset, the MG-US nomogram exhibited a higher AUC than the MG nomogram (0.899 vs 0.852, P = .01). DCA demonstrated the superiority of the MG-US nomogram over the MG nomogram. Second-look US features, including ultrasonic calcifications, lesions, and moderate or marked color flow, were valuable for distinguishing BI-RADS 4 calcifications without clinical manifestations and other abnormalities on MG.
A 3-year follow-up analysis of renal function in elderly patients with type 2 diabetes mellitus and an estimated glomerular filtration rate <90 mL/min/1.73m2: A retrospective cohort study
Authors: Wang Shao-feng , Zhang Hai-ying , Dai Hao-jun , Gong Jie , Wang Yan , He Ying , Liu Yun-lan , Hao Wei-rong , Wei Yi-hong
Published: July 2024

Type 2 diabetes mellitus (T2DM) is a risk factor for patients with impaired renal function. The onset of T2DM-induced diabetic kidney disease (DKD) is frequently sub-clinical, potentially culminating in end-stage renal disease. In the current study the factors influencing DKD in elderly patients diagnosed with T2DM were determined. A retrospective cohort study was conducted involving patients ≥60 years of age with T2DM from June 2019 to December 2022. The Cockcroft-Gault formula was used to estimate the glomerular filtration rate. The clinical information and biochemical indicators of patients with an estimated glomerular filtration rate (eGFR) < 90 mL/min/1.73m2 were collected. Patients were grouped based on a 3-year eGFR decline < 15% and ≥ 15%. The differences between the two groups were compared and the factors influencing the 3-year eGFR decline ≥ 15% were analyzed. A total of 242 patients were included, including 154 in the group with a 3-year eGFR decline < 15% and 88 in the group with a three-year eGFR decline ≥ 15%. Univariate logistic regression analysis showed that smoking cigarettes, and triglycerides (TG) and high-density lipoprotein levels were related to a 3-year eGFR decline ≥ 15% (P = .039, P < .001, and P = .011, respectively). Multivariate logistic regression analysis showed that the TG level was independently related to a 3-year eGFR decline ≥ 15% (P = .004; OR = 2.316). There was a significant linear relationship between the eGFR decline and TG level (P = .002). Patients with a TG concentration > 1.7 mmol/L had a more apparent decrease in the eGFR (P < .05). For elderly patients with T2DM and an eGFR < 90 mL/min/1.73m2, the TG level may be an important risk factor for deteriorating renal function that warrants actively intervention.
Kisspeptin expression levels in patients with placenta previa: A randomized trial
Authors: Katirci Yunus , Kocaman Adem , Ozdemir Ayse Zehra
Published: July 2024

Background:

This study aimed to explore the potential influence of kisspeptin (KISS1) levels on the etiology of placenta previa for early pregnancy diagnosis.

Methods:

The study included 20 pregnant women diagnosed with placenta previa and 20 pregnant woman with normal pregnancies between 2021 and 2022. Plasma KISS1 levels were determined through biochemical analysis, while genetic analysis assessed KISS1 and KISS1 receptor gene expression levels. Immunohistochemical methods were employed to determine placenta KISS1 levels.

Results:

The evaluation of KISS1 concentration in serum revealed a significant decrease in the placenta previa group compared to the control group (P < .001). KISS1 gene expression level 0.043-fold decreased in the placenta previa group (P < .001). Furthermore, the KISS1 receptor gene expression level increased 170-fold in the placenta previa group.

Conclusions:

Results from biochemical, immunohistochemical, and genetic analyses consistently indicated significantly reduced KISS1 expression in patients with placenta previa. These findings suggest a potential link between diminished KISS1 levels and the occurrence of placenta previa. KISS1 may play a critical role in the etiology of placenta previa. Detailed studies on angiogenesis, cell migration and tissue modeling should be conducted to understand possible mechanisms.
Postmenopausal giant uterine adenomyoma with adipose metaplasia: A case report and literature review
Authors: Qing Xuemei , Xie Min , Guo Hongying , Xie Bangfang , Huang Hailong , Zhang Yong , Ma Ying
Published: July 2024

Rationale:

Uterine adenomyomas (UAs) are common benign tumors, usually not exceeding 280 g or the weight of the uterus at 12 weeks gestation. Postmenopausal giant UAs of diameter larger than 20 cm are rare, as well as steatosis, but curable by surgical excision. Few cases of postmenopausal giant UAs have been reported.

Patient concerns:

Herein, we report a case of a 70-year-old female patient who presented with a giant pelvic tumor of about 20 cm × 18 cm × 20 cm with postmenopausal vaginal bleeding, and whose radiographic manifestations did not exclude the possibility of uterine malignancy.

Diagnoses:

Histopathology confirms an adenomyoma with partial adipose metaplasia.

Interventions:

We did an open laparotomy of hysterectomy, bi-adnexectomy, and pelvic adhesion release for the patient.

Outcomes:

Pathology revealed adenomyoma with adipose metaplasia. The patient recovered well and was discharged on postoperative day 7 with satisfactory follow-up.
Association between serum total cholesterol and the development of gastric cancer: A two-way two-sample Mendelian randomization study
Authors: Yan Peng , Zhao Dong
Published: July 2024

Previous epidemiologic studies have suggested a potential negative correlation between total cholesterol (TC) and Gastric cancer (GC); however, several observational studies have shown conflicting results and have failed to provide definitive evidence for a causal relationship between TC and GC. Therefore, we conducted a 2-sample bidirectional Mendelian randomization (MR) study to explore the genetic correlation and potential causal relationship between the 2 variables. We screened for single nucleotide polymorphisms (SNPs) associated with TC and GC utilizing a large-scale genome-wide association study (GWAS) public database. The causal relationship was analyzed using 5 MR analysis methods: inverse variance weighting (IVW), weighted median, MR-Egger regression, weighted mode, and simple mode. Additionally, reverse MR analysis was performed to evaluate the possibility of reverse causality. Sensitivity analyses were conducted, including heterogeneity tests, horizontal multiple validity tests, and leave-one-out tests. After meticulous screening, 79 SNPs were identified as instrumental variables (IVs). The IVW method revealed a causal relationship between TC and GC (OR = 0.844; 95% CI: 0.741–0.961; P = .01). Sensitivity analyses did not detect significant horizontal pleiotropy. Though heterogeneity was observed in the forward MR analysis (IVW, Qp = 0.0006), the results remained reliable as we utilized the IVW random-effects model as the primary analytical method. Furthermore, inverse MR analysis found no evidence of reverse causality between TC and GC, effectively ruling out the influence of GC on the reverse causality of TC. Our MR study provided evidence of a causal association between TC and GC, suggesting that TC acts as a protective factor against GC due to its negative association with the disease.
ENDOANGEL improves detection of missed colorectal adenomas in second colonoscopy: A retrospective study
Authors: Wang Yundong , He Chiyi
Published: July 2024

The ENDOANGEL (EN) computer-assisted detection technique has emerged as a promising tool for enhancing the detection rate of colorectal adenomas during colonoscopies. However, its efficacy in identifying missed adenomas during subsequent colonoscopies remains unclear. Thus, we herein aimed to compare the adenoma miss rate (AMR) between EN-assisted and standard colonoscopies. Data from patients who underwent a second colonoscopy (EN-assisted or standard) within 6 months between September 2022 and May 2023 were analyzed. The EN-assisted group exhibited a significantly higher AMR (24.3% vs 11.9%, P = .005) than the standard group. After adjusting for potential confounders, multivariable analysis revealed that the EN-assisted group had a better ability to detect missed adenomas than the standard group (odds ratio = 2.89; 95% confidence interval = 1.14–7.80, P = .029). These findings suggest that EN-assisted colonoscopy represents a valuable advancement in improving AMR compared with standard colonoscopy. The integration of EN-assisted colonoscopy into routine clinical practice may offer significant benefits to patients requiring hospital resection of lesions following adenoma detection during their first colonoscopy.