bluuebunny/crossref_metadata_2025 huggingface dataset:
The effects of saffron supplementation on cardiovascular risk factors in adults: A systematic review and dose-response meta-analysis
Authors: Zamani Mohammad , Zarei Mahtab , Nikbaf-Shandiz Mahlagha , Gholami Fatemeh , Hosseini Amir Mehdi , Nadery Maryam , Shiraseb Farideh , Asbaghi Omid
Published: December 2022

Introduction

Cardiovascular disease (CVD) is one of the leading causes of death and disability in the world and is estimated to involve more people in the next years. It is said that alternative remedies such as herbs can be used to manage the complications of this disease. For this reason, we aimed to conduct this meta-analysis to systematically assess and summarize the effects of saffron supplementation as an important herb on cardiovascular risk factors in adults.

Methods

A systematic search was done in PubMed, Scopus, and Web of Science to find eligible articles up to September 2022. Randomized controlled trials (RCTs) that evaluated the effects of saffron on lipid profiles, glycemic control, blood pressure, anthropometric measures, and inflammatory markers were included. In the meta-analysis, 32 studies were taken into account (n = 1674).

Results

Consumption of saffron significantly decreased triglyceride (TG) (WMD = −8.81 mg/dl, 95%CI: −14.33, −3.28; P = 0.002), total cholesterol (TC) (WMD = −6.87 mg/dl, 95%CI: −11.19, −2.56; P = 0.002), low density lipoprotein (LDL) (WMD = −6.71 mg/dl, 95%CI: −10.51, −2.91; P = 0.001), (P = 0.660), fasting blood glucose (FBG) level (WMD = −7.59 mg/dl, 95%CI: −11.88, −3.30; P = 0.001), HbA1c (WMD = −0.18%, 95%CI: −0.21, −0.07; P < 0.001), homeostasis model assessment-insulin resistance (HOMA-IR) (WMD = −0.49, 95%CI: −0.89, −0.09; P = 0.016), systolic blood pressure (SBP) (WMD = −3.42 mmHg, 95%CI: −5.80, −1.04; P = 0.005), tumor necrosis factor α (TNF-α) (WMD = −2.54 pg/ml, 95%CI: −4.43, −0.65; P = 0.008), waist circumference (WC) (WMD = −1.50 cm; 95%CI: −2.83, −0.18; P = 0.026), malondialdehyde (MDA) (WMD = −1.50 uM/L, 95%CI: −2.42, −0.57; P = 0.001), and alanine transferase (ALT) (WMD = −2.16 U/L, 95%CI: −4.10, −0.23; P = 0.028). Also, we observed that saffron had an increasing effect on total antioxidant capacity (TAC) (WMD = 0.07 mM/L, 95%CI: 0.01, 0.13; P = 0.032). There was linear regression between FBG and the duration of saffron intake. Additionally, the non-linear dose-response analysis has shown a significant association of saffron intervention with HDL (P = 0.049), HOMA-IR (P = 0.002), weight (P = 0.036), ALP (P = 0.016), FBG (P = 0.011), HbA1c (P = 0.002), and TNF-α (P = 0.042). A non-linear association between the length of the intervention and the level of HDL and DBP was also found.

Discussion

That seems saffron could effectively improve TG, TC, LDL, FBG, HbA1c, HOMA-IR, SBP, CRP, TNF-α, WC, MDA, TAC, and ALT.
Sea buckthorn pulp and seed oils ameliorate lipid metabolism disorders and modulate gut microbiota in C57BL/6J mice on high-fat diet
Authors: Wang Zhen , Zhou Shengmin , Jiang Yuanrong
Published: December 2022

Introduction

Non-alcoholic fatty liver diseases (NAFLD), along with the complications of obesity and dyslipidemia, are worldwide lipid metabolism disorders. Recent evidence showed that NAFLD could be ameliorated by diet and lifestyles by attenuating gut microbiota dysbiosis via the gut–liver axis. Sea buckthorn oils, including sea buckthorn pulp oil (SBPO) and sea buckthorn seed oil (SBSO), were investigated in this study for their beneficial effects on gut–liver axis in C57BL/6J mice on a high-fat diet.

Methods

Sixty of male C57BL/6J mice were assigned into five groups, fed with low-fat diet containing soybean oil (SO), high-fat diet comprising lard oil (LO), peanut oil (PO), SBSO or SBPO, respectively, for 12 weeks. Serum and hepatic biochemical analysis, liver and perirenal fat histological analysis, and fecal 16S rRNA gene sequencing were conducted to reflect the influence of five diets on gut-liver axis.

Results

Dietary SBPO reduced visceral fat accumulation, adipose cell size, serum and hepatic triglyceride, LDL-C levels, and hepatic cell damage score; increased gut microbiota diversity with a higher abundance of Lactobacillus, Roseburia, and Oscillibacter compared with PO. SBSO showed equal or weaker effects compared to SBPO.

Conclusion

This study demonstrates that dietary SBPO has the potential to ameliorate NAFLD and related metabolic disorders, like obesity and dyslipidemia, by modulating gut microbiota.
Genistein protects against hyperglycemia and fatty liver disease in diet-induced prediabetes mice via activating hepatic insulin signaling pathway
Authors: Zhang Nana , Zhang Weiyue , Guo Xinxin , Liu Jianlin , Li Shuying , Zhang Hongtai , Fan Bei
Published: December 2022

Introduction

Insulin signalingviathe insulin receptor (IR) may be associated with the amelioration of diet-induced metabolic syndrome. Genistein, a soy isoflavone, has been suggested to play a role in the amelioration of high-fat diet-induced metabolic disorders.

Methods

Here, we aimed to explore whether genistein regulates glucose and hepatic lipid by activating the insulin signaling pathway in diet-induced obesity mice.

Results

We showed that treatment of western-style diet-fed mice with genistein (60 mg/kg) significantly improved insulin resistance with decreased hyperglycemia and HOMA-IR index. These effects were linked to activating hepatic IRβ/PI3K/Akt signaling. Furthermore, genistein suppressed gluconeogenesis and promoted glycogen synthesis to maintain glucose homeostasis by increasing the phosphorylation of hepatic FOXO1/GSK3βin vivoandin vitro. The reduced level of insulin and upregulation of insulin signaling in genistein-treated mice also lead to an increase in hepatic energy status by inducing energy-sensing AMPK, reducing hepatic SREBP1c/ACC/FAS without affecting β-oxidation to prevent hepatic lipid accumulation. The protective effect of genistein on hepatic lipid accumulation was also validatedin vitro. Besides, genistein had little effect on improvements in intestinal function and liver inflammation.

Conclusion

Taken together, our results showed that genistein prevents insulin resistance and hyperglycemia through improvements in hepatic function. This study provides new insight into the mechanisms of genistein mediating glucose metabolism and suggests that genistein may be a promising diet ingredient for preventing prediabetes and hepatic lipid accumulation.
Structural, antioxidant, and immunomodulatory activities of an acidic exopolysaccharide from Lactiplantibacillus plantarum DMDL 9010
Authors: Huang Yan-yan , Wu Jia-min , Wu Wei-tong , Lin Jia-wei , Liang Yan-tong , Hong Zhen-zhen , Jia Xiang-ze , Liu Dong-mei
Published: December 2022

This study investigated the structural, antioxidant, and immunomodulatory activities of acidic exopolysaccharide (EPS-LP2) isolated from Lactiplantibacillus plantarum DMDL 9010. EPS-LP2 is composed of fucose (Fuc), arabinose (Ara), galactose (Gal), glucose (Glc), mannose (Man), and D-fructose (Fru) with a molar ratio of 0.13: 0.69: 8.32: 27.57: 62.07: 0.58: 0.46, respectively. Structural analysis of EPS-LP2 exhibited a smooth irregular lamellar surface, rod-like structure with swollen ends and slippery surfaces, and good thermal stability. Based on the methylation and NMR analysis, sugar residues including t-Manp, t-Glcp, 2-Manp, 6-Galp, 6-Glcp, and 4-Glcp were found to exist in EPS-LP2. In the 50∼400 μg/ml range, EPS-LP2 showed negligible neurotoxicity to RAW264.7 cells. Moreover, EPS-LP2 could protect RAW264.7 cells from oxidative injury by lowering the generation of reactive oxygen species (ROS), malondialdehyde (MDA), and the secretion of lactate dehydrogenase (LDH). In contrast, an increase in superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), and the concentrations of glutathione (GSH) were observed. Immunoreactivity assays showed that EPS-LP2 could suppress the expression of NO, tumor necrosis factor-α (TNF-α), and interleukin 6 (IL-6) and inhibit the activation of the mitogen-activated protein kinase (MAPK)/nuclear factor-κB-gene binding (NF-κB) cell pathway. Conclusively, EPS-LP2 could be a potential natural antioxidant and immunomodulatory agent in functional foods and medicines.
Case report: Recurrent lung infections following treatment with pralsetinib for an elderly patient with RET-fusion positive NSCLC
Authors: An Li , Chen Pengzhi , Wang Junfeng , Qin Xuebing , Liu Tingting , Gao Yanhong , Wang Peng , Zhang Dong , Fang Xiangqun , Zhang Zhijian
Published: December 2022

Patients with RET fusions represent 1-2% of all cases of non-small cell lung cancer (NSCLC), the majority of whom are younger, and are extremely rare in the elderly. As a selective RET inhibitor, pralsetinib has been shown to be efficacious and well-tolerated in patients with RET-fusion NSCLC. Nevertheless, there are currently insufficient data available for assessing the activity and safety of pralsetinib in elderly patients with NSCLC. Herein, we report an 81-year-old NSCLC patient with KIF5B-RET fusion, who achieved stable disease for more than 9 months at a low-dose of pralsetinib as second-line therapy. Of particular note, during pralsetinb therapy, his clinical course was complicated by cryptococcal pneumonia and staphylococcus aureus lung abscess. Our study demonstrates that pralsetinib is an effective therapeutic option that provides survival benefits for elderly NSCLC patients harboring RET fusion. However, during pralsetinb therapy, treating physicians should maintain particular vigilance for the increased risk of infection, especially in elderly patients.
Impact of total marrow/lymphoid irradiation dose to the intestine on graft-versus-host disease in allogeneic hematopoietic stem cell transplantation for hematologic malignancies
Authors: Saldi Simonetta , Fulcheri Christian Paolo Luca , Zucchetti Claudio , Abdelhamid Amr Mohamed Hamed , Carotti Alessandra , Pierini Antonio , Ruggeri Loredana , Tricarico Sara , Chiodi Marino , Ingrosso Gianluca , Bini Vittorio , Velardi Andrea , Martelli Massimo Fabrizio , Hui Susanta Kumar , Aristei Cynthia
Published: December 2022

Background and purpose

Graft-versus-host disease (GvHD) is a leading cause of non-relapse mortality in patients undergoing allogeneic hematopoietic stem cell transplantation. The Perugia Bone Marrow Transplantation Unit designed a new conditioning regimen with total marrow/lymphoid irradiation (TMLI) and adaptive immunotherapy. The present study investigated the impact of radiotherapy (RT) doses on the intestine on the incidence of acute GvHD (aGvHD) in transplant recipients, analyzing the main dosimetric parameters.

Materials and methods

Between August 2015 and April 2021, 50 patients with hematologic malignancies were enrolled. All patients underwent conditioning with TMLI. Dosimetric parameters (for the whole intestine and its segments) were assessed as risk factors for aGvHD. The RT dose that was received by each intestinal area with aGvHD was extrapolated from the treatment plan for each patient. Doses were compared with those of the whole intestine minus the affected area.

Results

Eighteen patients (36%) developed grade ≥2 aGvHD (G2 in 5, G3 in 11, and G4 in 2). Median time to onset was 41 days (range 23–69 days). The skin was involved in 11 patients, the intestine in 16, and the liver in 5. In all 50 TMLI patients, the mean dose to the whole intestine was 7.1 Gy (range 5.07–10.92 Gy). No patient developed chronic GvHD (cGvHD). No dosimetric variable emerged as a significant risk factor for aGvHD. No dosimetric parameter of the intestinal areas with aGvHD was associated with the disease.

Conclusion

In our clinical setting and data sample, we have found no clear evidence that current TMLI dosages to the intestine were linked to the development of aGvHD. However, due to some study limitations, this investigation should be considered as a preliminary assessment. Findings need to be confirmed in a larger cohort and in preclinical models.
Immune subtype identification and multi-layer perceptron classifier construction for breast cancer
Authors: Yang Xinbo , Zheng Yuanjie , Xing Xianrong , Sui Xiaodan , Jia Weikuan , Pan Huali
Published: December 2022

Introduction

Breast cancer is a heterogeneous tumor. Tumor microenvironment (TME) has an important effect on the proliferation, metastasis, treatment, and prognosis of breast cancer.

Methods

In this study, we calculated the relative proportion of tumor infiltrating immune cells (TIICs) in the breast cancer TME, and used the consensus clustering algorithm to cluster the breast cancer subtypes. We also developed a multi-layer perceptron (MLP) classifier based on a deep learning framework to detect breast cancer subtypes, which 70% of the breast cancer research cohort was used for the model training and 30% for validation.

Results

By performing the K-means clustering algorithm, the research cohort was clustered into two subtypes. The Kaplan-Meier survival estimate analysis showed significant differences in the overall survival (OS) between the two identified subtypes. Estimating the difference in the relative proportion of TIICs showed that the two subtypes had significant differences in multiple immune cells, such as CD8, CD4, and regulatory T cells. Further, the expression level of immune checkpoint molecules (PDL1, CTLA4, LAG3, TIGIT, CD27, IDO1, ICOS) and tumor mutational burden (TMB) also showed significant differences between the two subtypes, indicating the clinical value of the two subtypes. Finally, we identified a 38-gene signature and developed a multilayer perceptron (MLP) classifier that combined multi-gene signature to identify breast cancer subtypes. The results showed that the classifier had an accuracy rate of 93.56% and can be robustly used for the breast cancer subtype diagnosis.

Conclusion

Identification of breast cancer subtypes based on the immune signature in the tumor microenvironment can assist clinicians to effectively and accurately assess the progression of breast cancer and formulate different treatment strategies for different subtypes.
Invisible cervical cancers on MRI: Can the type of histology (SCC versus non-SCC) influence surgical planning?
Authors: Jeon Jungeun , Park Byung Kwan , Lee Jeong-Won , Choi Chel Hun , Lee Yoo-Young , Kim Tae-Joong , Kim Byoungi-Gie
Published: December 2022

Background

Invisible cervical cancers on MRI can indicate less invasive surgery. Cervical cancers consist of squamous cell carcinoma (SCC) and non-SCC, each with different long-term outcomes. It is still unclear if surgical planning should be changed according to the histologic type of cervical cancer when it is not visible on MRI.

Purpose

The purpose of the study was to determine if surgical planning for cervical cancer that is not visible on MRI is influenced by the histologic type.

Materials and methods

Between January 2007 and December 2016, 155 women had Federation of Gynecology and Obstetrics (FIGO) stage 1B1 cervical cancer that was not visible on preoperative MRI. They underwent radical hysterectomies and pelvic lymph node dissections. Among them, 88 and 67 were histologically diagnosed with SCC and non-SCC, respectively. The size of the residual tumor, depth of stromal invasion, parametrial invasion, vaginal invasion, lymphovascular invasion, and lymph node metastasis were compared between these patients using the t-test, Mann–Whitney U test, Chi-squared test, or Fisher’s exact test. The recurrence-free and overall 10-year survival rates were compared between the groups by Kaplan–Meier analysis.

Results

The mean sizes of residual tumors were 8.4 ± 10.4 mm in the SCC group and 12.5 ± 11.9 mm in the non-SCC group (p = 0.024). The mean depth of stromal invasion in the SCC group was 12.4 ± 21.2% (0%–100%), whereas that in the non-SCC group was 22.4 ± 24.4 (0%–93%) (p = 0.016). However, there was no difference in parametrial or vaginal invasion, lymphovascular invasion, or lymph node metastasis (p = 0.504–1.000). The recurrence-free and overall 10-year survival rates were 98.9% (87/88) and 95.5% (64/67) (p = 0.246), and 96.6% (85/88) and 95.5% (64/67) (p = 0.872), respectively.

Conclusions

The non-SCC group tends to have larger residual tumors and a greater depth of stromal invasion than the SCC group, even though neither is visible on MRI. Therefore, meticulous care is necessary for performing parametrectomy in patients with non-SCC cervical cancer.
Using meta-reasoning for incremental repairs in multi-object robot manipulation tasks
Authors: Parashar Priyam , Goel Ashok K. , Christensen Henrik I.
Published: December 2022

Robots tasked with object assembly by manipulation of parts require not only a high-level plan for order of placement of parts but also detailed low-level information on how to place and pick the part based on its state. This is a complex multi-level problem prone to failures at various levels. This paper employs meta reasoning architecture along with robotics principles and proposes dual encoding of state expectations during the progression of task to ground nominal scenarios. We present our results on table-top scenario using perceptual expectations based in the concept of occupancy grids and key point representations. Our results in a constrained manipulation setting suggest using low-level information or high-level expectations alone the system performs worse than if the architecture uses them both. We then outline a complete architecture and system which tackles this problem for repairing more generic assembly plans with objects moving in spaces with 6 degrees of freedom.
The analysis of lysine succinylation modification reveals the mechanism of oxybenzone damaging of pakchoi (Brassica rapa L. ssp. chinensis)
Authors: Li Shuhao , Zhou Yuqi , Xu Yang , Ran Shengxiang , Hou Maomao , Li Qingming , Zhong Xin , Zhong Fenglin
Published: December 2022

Oxybenzone (OBZ), one of a broad spectrum of ultraviolet (UV) absorbents, has been proven to be harmful to both plants and animals, while omics analysis of big data at the molecular level is still lacking. Lysine succinylation (Ksuc) is an important posttranslational modification of proteins that plays a crucial role in regulating the metabolic network in organisms under stress. Here, we report the changes in intracellular Ksuc modification in plants under OBZ stress. A total of 1276 succinylated sites on 507 proteins were identified. Among these sites, 181 modified proteins were hypersulfinylated/succinylated in OBZ-stressed pakchoi leaves. Differentially succinylated proteins (DSPs) are distributed mainly in the chloroplast, cytoplasm, and mitochondria and are distributed mainly in primary metabolic pathways, such as reactive oxygen species (ROS) scavenging, stress resistance, energy generation and transfer, photosynthetic carbon fixation, glycolysis, and the tricarboxylic acid (TCA) cycle. Comprehensive analysis shows that Ksuc mainly changes the carbon flow distribution, enhances the activity of the antioxidant system, affects the biosynthesis of amino acids, and increases the modification of histones. The results of this study first showed the profiling of the Kusc map under OBZ treatment and proposed the adaptive mechanism of pakchoi in response to pollutants and other abiotic stresses at the posttranslational level, which revealed the importance of Ksuc in the regulation of various life activities and provides a reference dataset for future research on molecular function.
The earliest cotton fibers and Pan-regional contacts in the Near East
Authors: Liu Li , Levin Maureece J. , Klimscha Florian , Rosenberg Danny
Published: December 2022

Fiber technology (cordage and textile) has played a central role in all human societies for thousands of years, and its production, application and exchange have deep roots in prehistory. However, fiber remains have only rarely been observed in prehistoric sites because they tend to decay quickly in normal environmental conditions. To overcome preservation problems of macroscopic remains, we employed microbotanical analysis on soils from anthropogenic sediments in activity areas at Tel Tsaf in the Jordan Valley, Israel (ca. 5,200–4,700 cal BC), and recovered fiber microremains. This includes at least two types of bast fibers and the earliest evidence of cotton in the Near East, some of which were dyed in various colors. Some of these fibers likely represent the remnants of ancient clothing, fabric containers, cordage, or other belongings. The cotton remains, probably derived from wild species originating in South Asia, predate the oldest known cotton domestication in the Indus Valley by about two millennia. Tel Tsaf played a pivotal role in trans-regional trade and exchange networks in the southern Levant, and the presence of cotton at the site points to possible connections with the Indus Valley as early as 7,200 years ago.
Optimization of a static headspace GC-MS method and its application in metabolic fingerprinting of the leaf volatiles of 42 citrus cultivars
Authors: Deng Honghong , He Runmei , Huang Rong , Pang Changqing , Ma Yuanshuo , Xia Hui , Liang Dong , Liao Ling , Xiong Bo , Wang Xun , Zhang Mingfei , Ao Xiang , Yu Bo , Han Dongdao , Wang Zhihui
Published: December 2022

Citrus leaves, which are a rich source of plant volatiles, have the beneficial attributes of rapid growth, large biomass, and availability throughout the year. Establishing the leaf volatile profiles of different citrus genotypes would make a valuable contribution to citrus species identification and chemotaxonomic studies. In this study, we developed an efficient and convenient static headspace (HS) sampling technique combined with gas chromatography-mass spectrometry (GC-MS) analysis and optimized the extraction conditions (a 15-min incubation at 100 ˚C without the addition of salt). Using a large set of 42 citrus cultivars, we validated the applicability of the optimized HS-GC-MS system in determining leaf volatile profiles. A total of 83 volatile metabolites, including monoterpene hydrocarbons, alcohols, sesquiterpene hydrocarbons, aldehydes, monoterpenoids, esters, and ketones were identified and quantified. Multivariate statistical analysis and hierarchical clustering revealed that mandarin (Citrus reticulata Blanco) and orange (Citrus sinensis L. Osbeck) groups exhibited notably differential volatile profiles, and that the mandarin group cultivars were characterized by the complex volatile profiles, thereby indicating the complex nature and diversity of these mandarin cultivars. We also identified those volatile compounds deemed to be the most useful in discriminating amongst citrus cultivars. This method developed in this study provides a rapid, simple, and reliable approach for the extraction and identification of citrus leaf volatile organic compound, and based on this methodology, we propose a leaf volatile profile-based classification model for citrus.
Integrated transcriptome and metabolome analysis reveals the anthocyanin biosynthesis mechanisms in blueberry (Vaccinium corymbosum L.) leaves under different light qualities
Authors: Zhang Jiaying , Li Shuigen , An Haishan , Zhang Xueying , Zhou Boqiang
Published: December 2022

Introduction

Blueberry (Vaccinium corymbosum L.) is a popular fruit with an abundance of anthocyanins in its leaves and fruits. Light is one of the pivotal environmental elements that affects plant growth and development, but the regulatory mechanism between light quality and anthocyanin formation is poorly understood.

Methods

An integrated transcriptome and metabolome analysis was performed to investigate the effects of white (control), blue (B), red (R), and red/blue (60R/40B) light on blueberry growth and reveal the potential pathway controlling anthocyanin biosynthesis in blueberry leaves.

Results

The anthocyanin content was significantly improved by the blue and red/blue light when compared with white light, whereas there was a significant reduction in the photosynthesis under the blue light, showing an inverse trend to that of anthocyanin accumulation. Transcriptomic analysis resulted in the assembly of 134,709 unigenes. Of these, 22 were differentially expressed genes (DEGs) that participate in the anthocyanin biosynthesis pathway, with the majority being significantly up-regulated under the blue light. Most of the photosynthesis-related genes that were down-regulated were expressed during anthocyanin accumulation. Targeted metabolome profiling identified 44 metabolites associated with anthocyanin biosynthesis. The contents of most of these metabolites were higher under blue light than the other light conditions, which was consistent with the transcriptome results. The integrated transcriptome and metabolome analysis suggested that, under blue light, leucoanthocyanidin dioxygenase (LDOX), O-methyltransferase (OMT), and UDP-glucose flavonoid glucosyltransferase (UFGT) were the most significantly expressed, and they promoted the synthesis of cyanidin (Cy), malvidin (Mv), and pelargonidin (Pg) anthocyanidins, respectively. The expression levels of dihydroflavonol 4-reductase (DFR) and OMT, as well as the accumulation of delphinidin (Dp), peonidin (Pn), and petunidin (Pt), were significantly increased by the red/blue light.

Discussion

The blue and red/blue lights promoted anthocyanin biosynthesis via inducing the expression of key structural genes and accumulation of metabolites involved in anthocyanin synthesis pathway. Moreover, there was a possible feedback regulating correlation between anthocyanin biosynthesis and photosynthesis under different light qualities in blueberry leaves. This study would provide a theoretical basis for elucidating the underlying regulatory mechanism of anthocyanin biosynthesis of V. corymbosum.
The impact of built environment on physical activity and subjective well-being of urban residents: A study of core cities in the Yangtze River Delta survey
Authors: Zhang Jing , Zheng Yan , Wen Tao , Yang Min , Feng Qiang ming
Published: December 2022

Objective

In cities with high population density in China, the impact of built environment on human health is rather complicated. Physical activities are an important factor in promoting people’s health. This study is aimed to explore ways of enhancing the residents’ intensity of physical activities and psychological health in a limited built environment. For this purpose, this study conducted research on 1875 residents from cities in the Yangtze River Delta in China to clarify the complicated correlations among the residents’ physical activities, the multi-dimensional geographic environment characteristics, and subjective well-being.

Methods

First, Neighborhood Environment Walkability Scale (NEWS-A), International Physical Activity Questionnaire Short Form (IPAQ-SF), and Subjective Well-being Scale for Chinese Citizens (SWBS-CC) were used to measure built environment characteristics, intensity of physical activities, and subjective well-being. Second, the correlations among built environment, physical activities, and subjective well-being were analyzed, which reflected different effects of built environment characteristics on physical activities and subjective well-being. Third, physical activities were viewed as a mediating variable in SEM to analyze the influence mechanism of each built environment characteristic on the subjective well-being of residents.

Result

Residents with different individual characteristics may have different levels of perception and usage of built environment. The intensity of physical activities has significant positive correlations with proximity to supporting facilities, accessibility of destinations, and public security, while no significant correlation with overall environmental aesthetics and street connectivity. The residents’ subjective well-being has significant positive correlations with accessibility of destinations, overall environmental aesthetics, and public security, while no significant correlation with proximity to supporting facilities and street connectivity. Physical activities not only have a direct effect on subjective well-being, but also a mediating effect on the correlations between subjective well-being and built environment characteristics.

Conclusion

In the future, more research could be conducted on the optimization of correlations between residential built environment characteristics and physical activities as well as subjective well-being, so as to gain a deeper understanding about the impact of residential built environment on people’s physical and mental health.
Cognitive and linguistic abilities and perceptual restoration of missing speech: Evidence from online assessment
Authors: Burleson Andrew M. , Souza Pamela E.
Published: December 2022

When speech is clear, speech understanding is a relatively simple and automatic process. However, when the acoustic signal is degraded, top-down cognitive and linguistic abilities, such as working memory capacity, lexical knowledge (i.e., vocabulary), inhibitory control, and processing speed can often support speech understanding. This study examined whether listeners aged 22–63 (mean age 42 years) with better cognitive and linguistic abilities would be better able to perceptually restore missing speech information than those with poorer scores. Additionally, the role of context and everyday speech was investigated using high-context, low-context, and realistic speech corpi to explore these effects. Sixty-three adult participants with self-reported normal hearing completed a short cognitive and linguistic battery before listening to sentences interrupted by silent gaps or noise bursts. Results indicated that working memory was the most reliable predictor of perceptual restoration ability, followed by lexical knowledge, and inhibitory control and processing speed. Generally, silent gap conditions were related to and predicted by a broader range of cognitive abilities, whereas noise burst conditions were related to working memory capacity and inhibitory control. These findings suggest that higher-order cognitive and linguistic abilities facilitate the top-down restoration of missing speech information and contribute to individual variability in perceptual restoration.
Social support as a mediator of the relationship between forgiveness and post-traumatic growth in hemodialysis patients: A structural equation modeling approach
Authors: Ye Yansheng , Tong Zongwu , Li Changqiong , Gao Xiufang , Sun Yane , Xu Jianqing , Xu Qian , Song Chengrong
Published: December 2022

Background

Post-traumatic growth (PTG) refers to the positive psychological changes experienced with individuals after struggling with highly challenging life circumstances. Forgiveness can facilitate positive outcomes such as reduced distress, anxiety, and depression. Many studies have tested the relationships among forgiveness, social support, and PTG; however, a mechanism of social support has not been completely explored in hemodialysis patients.

Objective

To test the relationship between forgiveness and post-traumatic growth and verify the mediating factor of social support on the relationship between forgiveness and PTG in hemodialysis patients.

Materials and methods

In a descriptive cross-sectional study using convenience sampling from March to May 2021, 497 hemodialysis patients from nine hospitals filled out the Perceived Social Support Scale (PSSS), Heartland Forgiveness Scale (HFS), Post-traumatic Growth Inventory (PTGI), and general information. Data were analyzed using SPSS, and structural equation modeling was used to explore the relationships among forgiveness, social support, and PTG.

Results

Forgiveness was significantly positively associated with PTG (P < 0.01). The proposed model provided a good fit to the data. Social support was found to play a partial mediating role between forgiveness and PTG (a*b = 0.122, BCa 95% CI: 0.078∼0.181).

Conclusion

The results imply that forgiveness significantly directly and indirectly is related to PTG. Forgiveness in hemodialysis patients should be detected and effectively managed to ameliorate positive effects on PTG. It is necessary for nurses to consider implementing forgiveness interventions with an emphasis on building social support strategies to help hemodialysis patients enhance their PTG.
Barriers and facilitators for access and utilization of reproductive and sexual health services among Female Sex Workers in urban and rural Maharashtra, India
Authors: Shewale Suhas , Sahay Seema
Published: December 2022

Background

The public health interventions among Female Sex Workers (FSWs) have mainly addressed HIV/ STI prevention. The focus of the HIV prevention program on FSWs' Reproductive and Sexual Health (RSH) has been limited, thus, rendering them at a higher risk of unintended pregnancies, delayed pregnancy detection, and utilizing unsafe abortion methods.

Methods

A multistakeholder analysis was performed to study access and use of RSH services among FSWs in urban and rural India. Between January 2016 and June 2019, a qualitative grounded theory approach was used to explore the FSWs' perspectives and experiences about services pertaining to HIV prevention, Antenatal Care (ANC), child delivery, abortion, and pregnancy prevention. Using purposive and convenience sampling, 29 In-Depth Interviews (IDIs), 2 Focus Group Discussions (FGDs) and 22 Key Informant Interviews (KIIs) were conducted with consenting FSWs and indirect stakeholders, respectively. Verbatim translated data was entered in NVivo12 Software and analyzed inductively.

Results

The following themes emerged: (1) Condomless sex, unintended pregnancy, vertical transmission, (2) Signs/ indication used for pregnancy detection causing delay (3) Pregnancy prevention methods used, (4) Pregnancy prevention or AIDS prevention, (5) Legal formalities as a barrier to access RSH, (6) Differential facility preference.

Conclusion

Pregnancy prevention is a greater motivation for condom use than HIV prevention among FSWs. Therefore, there is an emerging need to reallocate public health resources and redesign policies to meet the RSH needs of FSWs, especially for the prevention of unintended pregnancies. FSW-focused Information Education Communication (IEC) strategies for RSH service utilization are essential to reduce the burden of unintended pregnancies. The National HIV Targeted Intervention (TI) program needs to include pregnancy testing services and information to non-barrier contraceptive methods. An ambient policy environment calls for examining the need for male involvement in pregnancy, family planning and abortion decisions.
Profiling resilience: A latent profile analysis of German nurses' coping and resilience
Authors: Klingenberg Ingo , Süß Stefan
Published: December 2022

Introduction

Because of the shortage of nurses, it becomes crucial for organizations and health systems to keep nurses in their workforce. As individual resilience is positively associated with organizational commitment and negatively with mental disorders, it may reduce nurses' intention to leave the profession. Thus, individual resilience gained attention in research. Nevertheless, there is no common conceptualization of individual resilience in the literature. Rather, three prevalent understandings exist. Due to these multiple understandings, the role of coping in the context of resilience remains unclear. Against this background, the aim of this study is to analyze the relationship between nurses' resilience and coping based on a person-centered approach.

Methods

This study presents a latent profile analysis based on a survey of 210 German nurses. The profiles were generated based on the Brief Resilience Scale and Brief COPE. The Perceived Workload of Nurses' Scale and sociodemographic data were considered as explanatory factors using nominal logistic regression. Further, the relation with possible consequences was tested byχ²-test using the Irritation Scale and KUT Commitment Measure.

Results

The study identifies four different profiles of coping and resilience. The profiles “resistant” and “social-active” show rather low irritations and high organizational commitment. The “passive” profile has lower irritation scores than the “solitary” profile does, but the “passive” profile is associated with more irritation than the “resistant” or the “social-active” profile. Whereas the other profiles include characteristics of resilience, the “solitary” profile has a vulnerable nature. The analysis shows that more coordination and information problems, higher age, and not being in a leadership role are associated with a higher probability of belonging to the “solitary” profile. The chance of belonging to the “solitary” profile is significantly higher for women than for men, whereas women have a significantly lower chance of belonging to the “resistant” profile, compared to men.

Conclusion

The analysis shows that the three prevalent understandings of resilience are appropriate but it also indicates that future scientific debate requires more precision in defining individual resilience. The study contributes to sharpening the definition of resilience as well as to understanding the link between coping and resilience.
An electrochemical device to control sample pH locally in Lab-on-PCB devices: An investigation into spatial resolution
Authors: Maxted Grace , Estrela Pedro , Moschou Despina
Published: December 2022

During the recent pandemic outbreak, Lab-on-Chip devices did not manage to fully reach their potential in rapid diagnosis of pathogens, mainly due to the lack of cost-effective LoC solutions integrated with all required sample preparation modules. This paper presents such a critical step, aiming to translate electrochemical pH control into practical protein preconcentration modules, easy to integrate with subsequent quantification modules seamlessly via Lab-on-PCB technology. In this work we present a device capable of electrochemically controlling the pH of a solution local to an individually addressed electrode in a PCB array. The electrodes were functionalised with an electropolymerised self-assembled monolayer of 4-Aminothiophenol and were subjected to voltages of 0.2–0.4 V, evaluating for the first time the bias effect both over time and over space. This study enables for the first time the implementation of this technique for electrochemical pH control into practical Lab-on-PCB devices such as isoelectric focusing, via the informed design of such electrode arrays of appropriate size and spacing.
What Affects Your Risk For Alcohol- And Drug-Use Problems: You Get To Choose!
Authors: Oliver Alicia L. , Levy Sharon
Published: December 2022

You may have heard that the risk of some health problems, such as heart attacks or diabetes can be affected by a person’s diet and physical activity level. Did you know that there are also things in a person’s life that affect their risk of developing an alcohol- or drug-use problem? Scientists have identified risk factors that make people more likely to develop an addiction to alcohol or drugs. Certain risk factors cannot be changed, but others can be. This article reviews what we know about these risk factors.
Challenges associated with implementing anti-doping policy and programs in Africa
Authors: Ruwuya Jonathan , Juma Byron Omwando , Woolf Jules
Published: December 2022

Concerns regarding the capability of the International Olympic Committee to address doping in sport catalyzed the formation of the World Anti-Doping Agency (WADA) in 1999. In its establishment phase, WADA sought geopolitical legitimacy and support from governments (including non-Western states) for financing and acceptance. Africa was not considered during WADA's creation, relegating African states to a passive role in the global anti-doping program, and yet is still subject to the strict compliance requirements for WADA's global policy. African countries face challenges establishing anti-doping support structures and implementing the universal policy, including competing macro-level policy demands that favor addressing legacies of colonialism and human capacity development. To develop robust anti-doping support structures, African nations must spearhead anti-doping initiatives by leveraging existing infrastructure and encouraging collaborations between NADOs such that capacity can be built for policy implementation.
Climate change scenarios, their impacts and implications on Indian cardamom-coffee hot spots; one of the two in the world
Authors: Murugan Muthusamy , Alagupalamuthirsolai M. , Ashokkumar Kaliyaperumal , Anandhi Aavudai , Ravi Raju , Rajangam J. , Dhanya M. K. , Krishnamurthy K. S.
Published: December 2022

In this study, we investigated climatic parameters and predicted future changes in precipitation and atmospheric temperature levels based on RCP4. 5/8.5 scenarios in all cardamom-coffee hot spots of southern India. Our results showed more precipitation levels and patterns occurred in Cardamom hills (Kerala), followed by lower Puleny hills in Tamil Nadu. The least variation in precipitation levels has been noticed for temperate upper Puleny hills and Kodagu hills in Karnataka. RCP4.5/8.5 scenario analysis showed greater variability in precipitation, up to 180% increase and 90% decrease for all hot sports. The scenario analysis also predicted extreme temperature variations ranging from 0.5 to 8.5°C increase for the entire study region. A significant change in coffee yield and quality has been recorded over the last 30 years. Increased yield trends in coffee were noticed for Cardamom hills (CH) and Kodagu hills, but significantly lower coffee production was observed for lower Pulney hills. The mixed response of yield variability in coffee has been primarily attributed to the ongoing changing climatic factors. Ecophysiological studies of coffee, cardamom, and black pepper have proved that coffee would adapt well to future challenging climatic conditions, closely followed by cardamom and black pepper. Since all the coffee-cardamom hot spots in southern India undergoes considerable change in precipitation levels and pattern, necessary precautions, including water and irrigation management strategies, must be given utmost priority to increase the crop yield sustainability of these delicate cardamom-coffee hot spots in India.
Less is better than more with resection of periacetabular tumors – A retrospective 16 years study and literature review
Authors: Atzmon Ran , Drexler Michael , Dolkart Oleg , Goldstein Yariv , Dubin Jeremy , Sternheim Amir , Gortzak Yair , Bickels Jacob
Published: December 2022

Introduction

Wide resections of periacetabular tumors create a sizeable bony defect that inevitably results in severe loss of function. Reconstruction of such defects usually requires using large metal implants, a feature associated with considerable surgery extension and complications. The aim of this study is to report resection with no reconstruction of the bony defect. In this retrospective study, we reviewed a consecutive series of 16 patients diagnosed with malignant periacetabular tumors and underwent en-bloc resection without reconstructing their remaining bone defect.

Methods

Records were reviewed of 16 consecutive patients diagnosed with malignant periacetabular tumors and underwent en-bloc resection without reconstructing their remaining bony defect. Measurements included: the duration of surgery, blood loss, hemoglobin levels and the need for blood transfusions, data on other hospitalization characteristics, and intraoperative and postoperative complications.

Results

Sixteen patients with malignant periacetabular bone tumors and extensive bone destruction underwent wide periacetabular tumor resection with a mean follow-up of 75 months and a mean age of 53 years. The average HOOS score was 46 (range: 20 to 76), and the mean MSTS score was 13% (range: 0 to 15). The mean operative time was 4.1 h, and the mean blood loss was 1200 ml. At their most recent follow-up, patients had a mean shortening of their operated extremity of 4.8 cm, and all could ambulate with assisting devices.

Conclusion

Wide resection of periacetabular tumors without reconstruction provides acceptable levels of function and was associated with shorter surgical time, less blood loss and fewer postoperative complications compared to resection with reconstruction. Therefore, this approach may be considered a viable surgical option in patients with an extensive malignant periacetabular.

Level III

Retrospective study.
Canine osteosarcoma in comparative oncology: Molecular mechanisms through to treatment discovery
Authors: Simpson Siobhan , Rizvanov Albert A. , Jeyapalan Jennie N. , de Brot Simone , Rutland Catrin S.
Published: December 2022

Cancer is a leading cause of non-communicable morbidity and mortality throughout the world, similarly, in dogs, the most frequent cause of mortality is tumors. Some types of cancer, including osteosarcoma (OSA), occur at much higher rates in dogs than people. Dogs therefore not only require treatment themselves but can also act as an effective parallel patient population for the human disease equivalent. It should be noted that although there are many similarities between canine and human OSA, there are also key differences and it is important to research and highlight these features. Despite progress using chorioallantoic membrane models, 2D and 3Din vitromodels, and rodent OSA models, many more insights into the molecular and cellular mechanisms, drug development, and treatment are being discovered in a variety of canine OSA patient populations.
A Study on Magnetotelluric Characteristics of Magmatic Geothermal Systems
Authors: Li Jianhui , Zhang Wenbo , Li Mingjun , Liu Ying
Published: December 2022

The Magnetotelluric (MT) method is a widely used and effective method of exploring geothermal resources because it can reveal geological information at a great depth and is cost effective. In order to further improve the reliability and rationality of MT data interpretation, MT responses for a typical hydrothermal system and a hot dry rock (HDR) and partial melting system are investigated by a finite-element (FE) forward modeling approach based on unstructured tetrahedral grids that can handle with complex-shaped geothermal systems. These two geothermal models, designed by the 3ds Max software, are comprised of a clay cap, a reservoir, and a heat source, and are discretized into tetrahedral elements by TetGen software. The results show that the apparent resistivities at the broadband of frequencies are mainly affected by the shallow low-resistivity clay cap due to its strong shielding effects, and the induction arrows effectively reflect the boundary of the clay cap. The conductive heat-conducting path and heat source (1 S/m) considered in the models of the HDR and partial melting system could cause significant changes in the apparent resistivities and induction arrows at low frequencies. It suggests that in addition to the apparent resistivities, the induction arrows should be taken into consideration in MT data processing and inversion for better lateral resolution when exploring geothermal resources.