bluuebunny/crossref_metadata_2025 huggingface dataset:
The Role of Platelets in Central Hubs of Inflammation Regulation
Authors: Bo Yan
Published: May 2023

When receptors were found, the study of platelets turned to the signaling pathway. When platelets in the progression of some disease could provide valuable clues, the study of platelets turned to the relationship between platelets granules, platelet morphology and inflammatory immune responses. And even some geneticists through the analysis of genes tried to encode the secret of platelets and inflammation. We reviewed the study of platelets and found the substance released by platelets could perform complex functions. The formation of immunothrombosis was central to immunological platelet function. And it could lead to the release of platelets granules, thus initiating a cascade of inflammatory immune responses, which played a central role in adaptive and innate immune. And we found platelets induced epilepsy immune by S100b. In this review, we focused on sterile inflammation, pathogen infection immunity, tumor immunity and provided the latest evidence. Hoping in the future development, platelets shed new light on pathogens infection.
Research Progress in Pathogenesis and Treatment of the Anterior Cruciate Ligament Injury
Authors: Shen Tiannan
Published: May 2023

With the continuous development of the sports in China, sports trauma is also on the rise year by year, of which the former cruciate ligament injury is quite common. Anterior cruciate ligament (ACL), one of the two main types of intraarticular fibrous ligament, it can provide the rotational and translational stability for the knee. When it injurys, patients' exercise ability and life well-being will decline, and even lead to a series of complications, especially in women. The risk of the ACL injury in the women is almost 3.5 times that in men. There are many factors leading to ACL injury. Studies have shown that after anterior cruciate ligament injury, most patients choose surgical treatment. With the development of the Arthroscopic technique, most of the patients would be likely to choose the surgical treatment, especially the people that are young and active. The surgical treatment have several advantages, like the post-operative recovery is fast, less traumatic, fewer complications. At present, the surgical treatment is mainly reconstruction under arthroscopy. The reconstruction materials include autografts, allografts, artificial ligaments and so on. It is necessary to understand the difference of biochemical and biological characteristics of different grafts in the process of ligament healing. For some elderly patients or patients with other special needs, non-surgical treatment can also be selected. This article reviews the pathogenic factors, surgical methods, grafts, and other aspects for clinical reference.
The Current Status and Future Development of the HPV Vaccine
Authors: Zhu Yifan
Published: May 2023

The introduction of the HPV vaccine in 2006 significantly decreased the prevalence of cervi-cal cancer in the populace. Preventive HPV vaccinations have produced impressive outcomes based on the HPV mechanism. However, there is still great room for development in thera-peutic vaccinations. In addition, there are still many issues and skepticisms surrounding the safety, efficacy, and sexuality of the HPV vaccine. In a nutshell, the human papillomavirus is a widespread human infection that poses a major risk to human health by increasing the risk of malignant tumors like cervical cancer. The WHO is developing a global strategy to eradi-cate cervical cancer, and the HPV vaccine is successful in reducing HPV infection and the ill-nesses it causes. Future commercial manufacture of the 14-valent HPV vaccination will greatly contribute to the implementation of this strategy.
PD-1 and PD-L1 Treatment in Renal Cell Carcinoma
Authors: Dai Weiqi
Published: May 2023

Renal cell carcinoma as the top10 diagnosed cases of cancer. The treatment strategies such as surgical or ablative therapies works on early diagnosed patients but rarely works on metastat-ic RCC patients. However, nearly 30% of patients developed into metastases. As the common strategies that target the VEGF pathway, resistance is common in tumours, thus, more prom-ising method development is imperative. To overcome the evasion strategies, immune check-point inhibitors is promising treatment strategies. For renal cell carcinoma treatment, the an-ti-PD-1 medicine, Nivolumab and Pembrolizumab, and anti-PD-L1 medicine, Avelumab shows better outcome under the clinical trials. Despite the resistance situation occurs in some cases, immunotherapy anti-PD-1 and anti-PD-L1 showed better outcomes in both ORR and OS compare with targeted molecular monotherapy. Recently, the combination of anti-PD-1 or anti-PD-L1 with targeted drug (for example, TKI) or other type of immune checkpoint inhibi-tor (for example, CTLA-4) provides new perspectives.
The Relationship Between the Three Genes of Apolipoprotein E and the Hippocampus and Interference with Alzheimer's Disease
Authors: Lyu Shurui
Published: May 2023

Glycoproteins in the Apolipoprotein E (APOE) class have a role in controlling lipid metabolism. In astrocytes, microglia, vascular wall cells, and choroid plexus cells of the central nervous system, it is abundantly expressed. According to the rapid advancement of contemporary medicine, numerous investigations have demonstrated the existence of ApoE in chylomicron (CM), very low density lipoprotein (VLDL), intermediate density lipoprotein (IDL), and certain high-density lipoprotein (HDL). ApoE has also been demonstrated to have a substantial impact on Alzheimer's disease (AD). To enhance the investigation of innovative medications and give researchers a theoretical foundation, research on ApoE is required in this area. Because damage to the hippocampus is a significant concern for the population in Alzheimer's research, we need to study the effects of ApoE on the hippocampus. This paper will discuss the relationship between age and sex of hippocampal atrophy after the ApoE gene has caused AD. The paper through a method of literature review and the analysis of some clinical cases explores the impact of the ApoE gene on health, followed by a comparison of the disease state before and after, as well as the clinical pattern of hippocampal atrophy, including a description of clinical symptoms. The paper finds that ApoE significantly impacts AD and that the hippocampus is significantly atrophied after the onset of Alzheimer's disease.
Seaweed Potential in Environmental Improving
Authors: Su Qiyun , Han Lilin , Yu Xincheng
Published: May 2023

Owing to the effect of frequent human activities, the climate nowadays on plaxnet earth has become more and more stressed. Pollutions such as greenhouse gases are products from factories and other human activities and have become extremely severe, for the damage they could cause to both human health and surrounding environments. For decades, scientists have been seeking ways to mitigate the situation (while minimizing the cost), and seaweeds, a cheap and widespread species can be a key solution to several problems. In this paper, we demonstrate 3 uses--seaweed as forage to reduce methane production by cattle, seaweed as a heavy metal filter, and seaweed-based biofuel--and the mechanism of each. By doing research on the existing literature, we find that seaweeds have considerable potential in alleviating environmental pressure.
Diet and Exercise Treatment and Prevention for Non-alcoholic Fatty Liver Diseases Patients
Authors: Kong Dehao
Published: May 2023

Non-alcoholic fatty liver disease, a chronic metabolic disease, has been studied for decades. There is already well-recognized pathogenesis from pathology, epidemiology, physiology, gene expression, etc. While the understanding of the disease itself is increasing, therapies for this issue seem to have some obstacles: there has been no officially accepted direct pharmaceutical treatment(targeted drugs) until now. Nevertheless, lifestyle regulation has been investigated a lot to fill in this gap. Many researches have already given recommendations in fields of diets or physical activities. However, there is a lack of a comprehensive review to combine both perspectives and give an overview of the disease. This article will review the researches on the lifestyle recommendations for NAFLD patients from both diet and exercise aspects. All the references throughout this research, including journals and literature reviews, are conducted from online databases. The content will mainly discuss the effectiveness of different types of diet and how exercise taking place with respect to reducing the NAFLD risk factors. In brief, most current experimental/observational results suggest that a Mediterranean diet combining with moderate intense exercise could be remarkably beneficial in the management of NAFLD.
Overview of Alzheimers Disease
Authors: Du Xinli
Published: May 2023

Alzheimer's disease (AD) has become more and more common in older people, and the data show that the number of people with AD might increase rapidly in the next few decades if there are no interventions and prevention. However, some people are still confused between AD and dementia. Lots of people believe that dementia is a sign of getting old, so it is common and normal. Thus, some people with AD may miss the most important time to find treatment, which could cause them to be in a more serious condition. Knowledge about AD is still not propagated. This paper wants to show the importance of familiarity with the symptoms and treatment of AD. Forgetfulness is one of the typical symptoms, but there are other symptoms that people are not aware of, such as personality change, depression, and language ability. Therefore, people need to either prevent this disease or get intervention earlier. Although there is no medication or surgery to cure AD, nonpharmacologic and pharmacologic treatments are helpful to reduce some symptoms and slow the progress of AD. A healthy lifestyle also plays a significant role in preventing AD, and a healthy lifestyle could decrease the risk of AD and have positive outcomes for people with AD.
Research Progress of Postpartum Stress Urinary Incontinence
Authors: Jia Hui
Published: May 2023

Postpartum stress urinary incontinence (SUI) is one of the gynecological disorders that plague postpartum women, which severely affects womens daily work and life and may even cause anxiety and depression among women while decreasing their quality of life. In recent years, conservative treatment methods have been explored and applied extensively in postpartum SUI rehabilitation. Experimental data suggest that providing specific treatments for specific groups can greatly improve the efficiency of treatment and that classifying different types of treatments can also effectively promote the advancement of related diagnostic methods. This article systematically reviews the literature on the pathological mechanisms, and conservative treatment of postpartum urinary incontinence (UI), and discusses the optimal treatment methods for different etiologies, providing some insights for the rehabilitation and management of patients with postpartum SUI.
The Pathogenesis of Epilepsy
Authors: Sun Kaihui
Published: May 2023

Epilepsy, a group of chronic brain diseases characterized by different level of dysfunction of movement, sense, consciousness and autonomic nerve. The most common factors include: genetic factors, injury of brain cell and so on. At the molecular level, the imbalance between inhibition and excitation is considered as a concrete mechanism. When the ion channels on membrane change, the flow of ions will be interfered so that the excitability of cells will change, probably leading to epilepsy. Also, when the production of neurotransmitters goes wrong, normally the amount of inhibitory transmitter like GABA declines, and neurons will be over-excited. In addition, other reasons like parasite infection can also lead to epilepsy. This review aims to summarize the literatures investigating the relationship between different ion channels and epilepsy and the influence of excitatory and inhibitory neurotransmitters on epilepsy. This article does not only illustrate possible reasons causing epilepsy but, for each related channel or receptor protein, the basic information, subunit of protein and physiological function will be also covered in the review. The purpose of this article is to sort out the current researches on the pathogenesis of epilepsy so that people can have a comprehensive grasp of this field.
Channelopathies in Epilepsy: from Precision Medicine to Gene Therapy
Authors: Zhang Yiying
Published: May 2023

Epilepsy is a common and debilitating neurological disease with a significant genetic component. Inherited or de novo mutations in ion channels resulting in periodic network hyperexcitability is a major cause of epileptogenesis. Understanding of the genetic etiology of epilepsy opens up the avenue of personalized treatment. A range of precision medications are designed to target the defective ion channels, with varied effects. In addition, the underlying mechanisms of channelopathies can also be addressed by gene therapy. Expression of mutated ion channel genes can be regulated via gene replacement or gene silencing approaches, including viral vector-mediated gene replacement and antisense oligonucleotides. Aside from directly compensating of ion channel dysfunction, another strategy of gene therapy involves the overexpression of certain ion channels to modulate neuronal excitability, which particularly targets focal epilepsies. In line with the paroxysmal nature of epileptic seizures, optogenetic and chemogenetic approaches, which permits conditional activation of gene products can be particularly beneficial. The ideal gene therapy to treat genetic epilepsies and channelopathies would be in vivo gene editing, making precise gene modifications to correct mutations harbored by each individual. Advances in CRISPR- Cas technology has brought the idea closer to reality, yet technical and ethical concerns surround its therapeutic application.
Research Progress on the Relationship Between the Regulation of SLC6A4 Gene and Anxiety Disorders
Authors: Zheng Hanchang
Published: May 2023

Anxiety disorder is one of the most common mental disorders. Numerous studies have demonstrated the critical role played by genetic variables in the etiology of anxiety disorders. SLC6A4, which encodes serotonin transporter, is considered to be an important gene associated with anxiety susceptibility. The SLC6A4 gene's upstream promoter has a polymorphism region that has an impact on the transcriptional activity of the gene. Research has shown that this promoter polymorphism has a certain relationship with the occurrence of anxiety disorders and drug treatment. Anxiety disorders are also linked to SLC6A4 gene methylation and intron 2 (Stin2) polymorphism. Stin2 point and SLC6A4 gene methylation are all related to gene expression. This review summarizes the current research on the relationship between SLC6A4 gene promoter polymorphism, Stin2 polymorphism, and SLC6A4 gene methylation in the pathogenesis and drug treatment of anxiety disorder, to understand the current research progress of SLC6A4 gene expression in anxiety disorder.
Interaction Between Neuroimmune Activation Mechanisms in Epilepsy: the S100b Signaling Network and Brain-gut-bio-axis
Authors: Bo Yan , Sha Ren , Yu Haodong
Published: May 2023

Epilepsy is a syndrome characterized by abnormal firing in the brain, with numerous risk factors. Autoimmune central nervous system diseases are currently being widely explored; however, the neuroimmune processes involved in epilepsy have not been fully elucidated. This disorder is associated with the rise in the blood protein S100b concentration; hence, S100b levels are considered damage markers. From a recent review, we discovered the interaction of epilepsy with neural immunity and intestinal immunity. Neural immunity in epilepsy is associated with S100b generation and consumption. Therefore, we expect that S100b can be used as immune activation material to amplify immune responses in epilepsy simultaneously with intestinal immune suppression. The symbiotic relationship with intestinal biological immune upregulates the intestinal immune function, alleviating adverse outcomes of neural immunity in local brain regions.
Well-Designed wearable devices in healthcare
Authors: Li Jiahe
Published: May 2023

In recent years, wearable devices have gradually become a hot topic in the society. Due to their advantages such as ease to carry, ease to operate and diverse functions, the scientific community and businesspeople are developing them. Numerous new products, such as smartwatch eyes, have entered the market, which reflects the huge demand for wearable devices in today's society. Wearable devices in medicine and health monitoring have played a vital role in such aspects, such as early detection of diseases and low-cost medical services. But distance wearable devices into everyone's life is still a long way to go. This paper studies the current wearable devices' problems, such as privacy leak risk and poor battery life, and wearable devices' potential development direction in the future. It is concluded that wearable devices have achieved good development results in medical treatment. Wearable devices come in various forms and have unlimited development potential in the future. Its importance to the intelligent era is undeniable. Wearable devices have put forward solutions to solve the problem of insufficient social resources.
Nonenzymatic Glucose Biosensors: Latest Advances and Perspectives
Authors: Han Qi , Xu Haiyi
Published: May 2023

Over the sixty years since glucose biosensor was introduced, development of glucose biosensor had experienced three generations. Considering the increasing demand of glucose biosensor, research and development has been carried out for more promising nonenzymatic glucose biosensor. Compared to the traditional enzyme-based glucose biosensor, nonenzymatic sensor is more capable to continuous glucose detection and has higher stability. Additionally, nonenzymatic glucose biosensor has a lower fabrication cost, which can be beneficial to the wide range of patients with the need for constant checking for blood glucose concentration. This paper introduces two proposed nonenzymatic glucose detection models: activated chemisorption and incipient hydrous oxide adatom mediator. As the developing trend of glucose biosensors is toward wearable and continuous glucose monitoring, two wearable sensors and working principles are introduced. This paper describes the application progress of different types of materials in enzyme-free blood glucose sensors, puts forward the existing problems in the application of enzyme-free blood glucose sensors, and looks forward to its future application prospects.
Pharmacological Therapy for Obesity
Authors: Sun Peiming
Published: May 2023

Obesity is the main obstacle to human health in the world today, and it is more and more popular in the world.There are many methods to treat obesity in modern society, such as behavioral therapy, surgical treatment and pharmacological therapy.The author aims to give a review of pharmacological therapy for obesity based on existing literature research results and data. This paper mainly introduces the three drugs which are Phentermine, Sibutramine and Orlistat their mechanism.The result shows that these three drugs are applicable to moderate and severe obesity, and they can not be overused. Sibutramine, which can increase the risk of serious cardiovascular and cerebrovasular diseases, has been banned. The remaining two drugs, Phentermine and Orlistat, can be taken normally as long as they are under the guidance of doctors.
Impact, Responses and Future Prediction of Climate Change on the Phenology of Jellyfish
Authors: Liu Yangxi
Published: May 2023

Climate variation can be devastating to marine life. This essay mainly focuses on how jellyfish cope with changes in ocean temperature and whether they benefit or are also affected by the population's decline. In terms of whether jellyfish benefit from climate change, this paper focuses on two case studies: the mass propagation of jellyfish in the coastal areas of China and the abundance change of jellyfish in the Bering Sea area. The results conclude that jellyfish are increasing because of climate change. However, for the case study on the decrease of the race caused by the influence of jellyfish, this paper only found that it occurred in Humboldt Current, West Greenland Shelf, and Oyashio Current. Through comparative study, this paper demonstrates that jellyfish mainly benefited from climate variation because overfishing significantly reduced their predators. Critical species of the Marine food chain were transformed into flagellates. Flagellates reduce the oxygen content in the ocean. In addition, the paper found that the mortality of individual jellyfish in the study was increased by ocean acidification due to climate change. The increase in mortality rate is because the jellyfish's reproductive and body functions are greatly affected, leading to higher mortality. This discovery proves that there are still a few jellyfish that could be negatively affected by climate change. As a result, jellyfish, with their simple but adaptable bodies, gradually replaced fish as the dominant creatures in the water. Since studies of jellyfish and their corresponding measures are still scarce, researchers will need more attention to these small and unremarkable creatures in the future. Even in the face of human overfishing, their numbers are still more significant than the correct number. To restore the marine ecosystem balance, scientists must do something to reduce the number of jellyfish in the ocean.
Climate Change and Its Impact on Butterflies
Authors: Chen Jieyu , Chen Yilin , Fan Xinquan , Yao Yannan
Published: May 2023

Climate change had been influencing the world since the industrial revolution when fossil fuels including coal and petroleum were greatly used for industrial and production purposes. Increasing output of greenhouse gases had blocked more heat in the atmosphere, increasing the global temperature. Butterflies, from the class Insecta, had been living for thousands of years. These insects sit in a unique niche, considering their special place as both pollinators and primary consumers. Studying the butterflies will be a good approach to figure out the impact of climate changes on the ecosystems, by studying how butterflies are affected by climate changes, since they adapted and lived for billions of years. The results had shown that while butterflies have a certain extent of phenotypic plasticity to combat climate change, overall, climate change is destroying their lifespan and behaviors, causing losses in populations of butterflies throughout the globe. Our paper gives a rough frame about how, or in what factors, butterflies are influenced by climatic changes. However, more studies are needed to further investigate all the influences climate change conducted on butterflies. Also, more acts need to happen to successfully stop climate change from making butterflies and the biospheres even worse.
CAR T Cell Therapy: Evolutions and Emergent Improvements
Authors: Zhang Wei
Published: May 2023

One of the latest developments in the field of anti-cancer immunotherapy is chimeric antigen receptor (CAR) T cell therapy, which is considered magnificent and impressive owing to its superior response rates and efficacy. It has been proven to exhibit great efficacy in curing patients with B cell lymphoma and leukemia, and sometimes multiple myeloma as well. Nevertheless, despite the significant outcomes it has displayed, several limitations and restrictions still deeply restrain CAR T cell therapy from being widely used throughout the world. Particular challenges associated with T cells range from severe cytokine-related toxicities, the on-target off-tumor effect, and antigen escape, to inferior CAR T cell trafficking and immunosuppressive tumor microenvironment. To address the related problems, investigators learn from the evolutions of CAR design and incessantly attempt to modify and ameliorate CAR constructs and launch it to the wider extent of solid tumors and malignancies. A large array of methods and strategies have been adopted by investigators to fulfill this goal, ameliorating the efficacy, security, and applicability of CAR constructs. In this review, we will concentrate on the evolutions of CAR designs, and several limitations CAR T cell therapy recently faces, along with some innovative strategies come up by researchers to tackle them and explore the clinical benefits of this therapy against various cancers.
The Value of Yogurt and Its Function in Health Care
Authors: Yao Suqian
Published: May 2023

Yogurt is a dairy product that is high in nutritional content. Yogurt is high in protein, calcium, vitamins, and probiotics, making it beneficial to the human body. Consuming Lactobacillus-containing yogurt can help to enhance the intestinal environment and preserve intestinal flora equilibrium. Yogurt contains micronutrients that can boost the human body's innate immune system and reverse immunological weakness. Yogurt contains lactic acid, which can help to eliminate dangerous germs and improve digestion. Yogurt's phytosterols can help decrease blood cholesterol levels. Drinking yogurt can also help lactose-intolerant patients avoid the symptoms of lactose intolerance. Yogurt is a potential cancer treatment because it inhibits carcinogens and decreases inflammation. Patients suffering from diarrhea can minimize the frequency and duration of their symptoms by consuming yogurt. Yogurt can also help with chronic intestinal constipation in youngsters and constipation in pregnant women, especially when combined with bifidobacterium longum. The improved serum levels of total cholesterol and LDL cholesterol after consuming probiotic-containing yogurt suggest that the yogurt could be used to treat nonalcoholic fatty liver disease. The nutritional value and health benefits of yogurt were summarized in this article.
Types of vegetarian dietary patterns and their impact on diabetes and its complications
Authors: Zheng Yuanyin
Published: May 2023

Globally, diabetes is on the rise year by year, with type 2 diabetes accounting for a larger proportion. The choice of dietary pattern has a very significant part in the prevention and control of diabetes, especially for type 2 diabetics. Vegetarian and plant-based dietary patterns have received very wide attention in recent years. Studies have indicated that vegetarian diets can help people with obesity and body weight loss, and that vegetarians are much less likely to develop diabetes than omnivores, making them a very popular and widely recommended diet in recent years. Vegetarian or plant-based diets can lower the chance of developing diabetes and control its progression. Different types of vegetarian diets have different effects and there are some differences in how they affect diabetes, but all can help in some way. By comparing recent studies, a vegetarian diet can help treat and improve diabetes and its complications in several ways: cardiovascular disease, gut microbiota, kidney, vision, blood sugar, and inflammation.
Third Generation ALK Inhibitors - The Development of Lorlatinib and the Problems that Exist
Authors: Jia Mengzhan
Published: May 2023

The malignant tumor with the greatest morbidity and fatality rates in the world today is lung cancer, from which Non-Small Cell Lung Cancer (NSCLC) accounts for 85%. To treat NSCLC, a variety of targeted therapeutics been developed in medicine. ALK inhibitors are one of them, and they're frequently used to treat NSCLC.The 3rd Generation of ALK inhibitors are now in use, starting with the initial 1st generation ALK inhibitors. Because the development of 1st and 2nd generation ALK inhibitors medicines has been motivated by a number of unfavorable factors. These medications include the 3rd generation ALK inhibitor lorlatinib as well as the 2nd and 3rd generation ALK inhibitors ceritinib and alectinib. Current study discusses the clinical features, effectiveness, and side effects of lorlatinib as well as its pharmacological effects.
Principle and Application of CAR-T Cell Therapy for Cancer
Authors: He Ruonan , Huang Yingqi , Qian Ruobing
Published: May 2023

CAR-T therapy is a High-profile technology in cancer immunotherapy, which has developed rapidly and has made great achievements in the treatment of hematologic tumors. Its therapeutic principle makes CAR-T cell therapy a great advantage in the treatment of relapsed refractory chronic lymphocytic leukemia. However, CAR-T cell therapy still faces many problems, such as side effects, off-target effects, and the lack of specific antigen deficiency on the surface of solid tumors and so on. At present, it is an important research direction to reduce the impact of side effects on patients and its application in solid tumors. This paper focused on the principles and application of involved in CAR-T cell therapy, and the side effects brought by CAR-T therapy were sorted out. Finally, the further development of CAR-T therapy has prospected
Efeitos tóxicos causados pelo cigarro eletrônico - uma revisão de literatura
Authors: Gutecoski Carolina Almeida , Vieira Rosangela , Broetto Biazon Ana Carla
Published: May 2023

O uso do cigarro eletrônico (CE) vem se popularizando cada vez mais, de modo que o número de usuários tem aumentado consideravelmente nos últimos anos. No Brasil, não há dados recentes sobre o uso deste dispositivo e, apesar de ser considerado menos prejudicial à saúde, quando comparado ao cigarro convencional, o uso do CE pode trazer complicações a saúde, o que é preocupante visto que tem sido aderido por jovens e adolescentes como uma alternativa para o uso da nicotina com apelo tecnológico e estético. Diante deste contexto, o objetivo deste estudo foi realizar uma revisão bibliográfica sobre os efeitos tóxicos e riscos que o cigarro eletrônico pode causar no organismo humano. O estudo foi desenvolvido mediante levantamento bibliográfico dos últimos oito anos, nas bases de dados SciELO e MEDLINE. As publicações encontradas foram organizadas como de pesquisa e de revisão e, posteriormente, categorizadas em quatro temas centrais do CE: história e características; epidemiologia; efeitos tóxicos e influência na cessação do tabagismo. Apesar de ser um produto que se encontra no mercado há décadas, os dados acerca do CE ainda são escassos e superficiais, impossibilitando assim evidências fortemente embasadas a respeito dos danos causados à saúde por conta de seu uso.
Effect of Fundamental Factors on Stock Return (On LQ-45 Index Companies In Indonesia Stock Exchange 2017-2020)
Authors: Simahatie Mai , Inuzula Lakharis
Published: May 2023

This research is an associative research with a quantitative approach.The use of a quantitative approach in this study is intended to test the hypothesis by using statistical calculations to examine the effect of the independent variable on the dependent variable under study. This research will be conducted on the Indonesia Stock Exchange through the official IDX website, namely: http/www.idx.co.id. This research was conducted from July 2021 to December 2021.Typethe data used in this study is quantitative data, namely data measured on a numerical scale (numbers). The population used in this study are companies on the LQ-45 index listed on the Indonesia Stock Exchange from 2017 - 2020, where there are 45 LQ-45 index issuers which will change every 6 months or the period of February and August every year. year. The sampling technique in this study was purposive sampling which was selected based on certain criteria in accordance with the research objectives.
CARE OF NEW BORN INFANTS ACCORDING TO THE CULTURAL PERSPECTIVE OF THE BATAK TOBA TRIBE IN HUTA BAYU RAJA DISTRICT
Authors: Sondang Sidabutar
Published: May 2023

Newborn (neonatal) is the first 28 days of human life. At this time there is a process of adjusting the baby's body system from intra-uterine life to extra-uterine life. This is the period that needs extra attention and care because this is the period when the mortality rate is the highest. The culture of the Toba Batak tribe has certain traditions that have been applied from generation to generation until now in terms of caring for newborns. This study uses a qualitative phenomenological design which aims to find out and dig deeper about newborn care according to the cultural perspective of the Toba Batak tribe in Huta Bayu Raja District, Simalungun Regency. Data collection was carried out from January 10 2014 to March 28 2014 using purposive sampling with a sample of five participants. The data collection process was carried out by in-depth interviews using a tape recorder. The results showed that care for newborns according to the Toba Batak cultural perspective consisted of organ care, umbilical cord care, hygiene and skin care, gastrointestinal care, maintaining temperature and warming the baby's body, fulfillment of nutrition, giving immunity, and other special care, namely marempas, maresek-esek and giving small amounts (blessings). The results of this study are expected to be used as knowledge and information material for nurses in getting to know the culture of the Toba Batak tribe and planning comprehensive nursing care related to newborn care. This culture must also be filtered because there is a culture that has a negative impact on the health of the baby, and it is necessary to provide counseling related to the care of newborns.
THE RELATIONSHIP BETWEEN LEVELS OF ADOLESCENT KNOWLEDGE AND PREVENTION OF CLASS X CERVIC CANCER AT TAMAN SISWA PEMATANGSIANTAR HIGH SCHOOL 2019
Authors: Nurmala  , Ratih Angeli Pasaribu  , Dewi Wandha Syahputri Daulay
Published: May 2023

Cervical cancer is cancer that appears in cells in the cervix. Cervical cancer in Indonesia ranks second in the order of malignancy in women. The incidence of cervical cancer was 5,786 cases or 10.3% of other malignancies. In fact, around 500,000 women worldwide are diagnosed with cervical cancer and an average of 270,000 people die each year. The purpose of this study was to determine the level of knowledge of tenth grade girls at Taman Siswa Pematangsiantar High School, prevention of cervical cancer in tenth grade at Taman Siswa Pematangsiantar High School, and the relationship between the level of knowledge of young women and prevention of cervical cancer for class X at Taman Siswa Pematangsiantar High School. This research method is descriptive correlation through cross sectional approach, with a population of 100 and obtained 50 samples selected by purposive sampling and data collection for the dependent variable and independent variable was carried out simultaneously through a questionnaire instrument. The results showed that there were 36 respondents (72%) with good knowledge and 14 respondents (28%) with poor knowledge. Based on the results of the chi-square statistical test with a significance level of a = 0.05, a value of p = 0.01 was obtained, which means that there is a relationship between the level of knowledge and prevention of cervical cancer.
THE INFLUENCE OF THE NUMBERED HEAD TOGETHER (NHT) METHOD IN IMPROVING CLASS VIII STUDENT LEARNING OUTCOMES IN PAI SUBJECTS AT SMP NEGERI 2 BANDAR MASILAM SIMALUNGUN REGENCY
Authors: Chairuddin Siregar  , Riza Apriyani
Published: May 2023

This type of research is quantitative research with an experimental method approach.The results of the research in this thesis, the learning model used in this study is Number Head Together (NHT). The obstacles encountered in implementing the Numbered Head Together (NHT) learning method are first, students are not familiar with the Numbered Head Together (NHT) learning method. Second, the relationship between students and friends in one discussion group in teaching and learning activities is still lacking. Third, the participation and seriousness of students in teaching and learning activities is still lacking. Fourth, the lack of effective use of time in teaching and learning activities. Fifth, there were some students who could not answer the questions. The solution to facing these obstacles is the need to use the Numbered Head Together (NHT) learning method in learning, not only in the subjects of Islamic Religious Education but in other subjects. In addition, it is necessary to reduce the use of the lecture method in the application of the Numbered Head Together (NHT) learning method, and a teacher needs to look at the abilities of each student, so that the distribution of groups is fair and equitable. The use of the Numbered Heads Together method affects student learning outcomes. It is known that there is a significant (real) difference between the average student learning outcomes in the experimental class and the control class. In addition, seen from the results of posttest calculations for the experimental class using the Numbered Heads Together method, the average value was 77.70. this shows a higher value compared to the control class that does not use the Numbered Heads Together method obtained 65.00. Thus the average value of student learning outcomes taught by the Numbered Heads Together method is significantly higher than the students taught not using the Numbered Heads Together method.
THE EFFECTIVENESS OF EVERY ONE IS TEACHER HERE (ETH) TYPE ACTIVE LEARNING STRATEGY ON LEARNING OUTCOMES OF CLASS II STUDENTS IN JUNIOR HIGH SCHOOLS PRIVATE MUHAMMADIYAH AT TAQWA TEBING TINGGI
Authors: Winda Novianti  , Ine Ismayanti Purba
Published: May 2023

The current research study utilizes a type of correlation research, meaning that it is related or interrelated. That is, there is a reciprocal relationship between one variable and another variable. The results of this study are based on the results of calculations with the help of IBM SPSS 22 for windows software, it can be seen that of the 12 statements tested it can be seen that all instruments are valid, becausethe results of rcount > rtable. Meanwhile, based on Cronbach's alpha value of 0.972, it can be obtained that the questionnaire is declared reliable. Based on data analysis it is known that the relationship obtained through the product moment correlation test between active learning strategies of the Every One Is Teacher Here (ETH) type and learning outcomes in Muhammadiyah Private Middle Schools At Taqwa Tebing Tinggi of 0.630. These results are interpreted roughly or simply by matching the calculation results with the correlation index number "r" product moment. It turns out that the magnitude of rxy (0.630) which is 0.39 – 0.70 means that there is a positive correlation between variables X and variable Y, there is an adequate or moderate correlation. If the results are interpreted roughly or simply by matching the calculation results with the correlation index number "r" product moment. It turns out that the magnitude of rxy (0.630) which ranges from 0.70 to 0.90 means that there is a positive correlation between variables X and Y that has a strong or high correlation. From the results of the calculation of the Determinant Coefficient, it can be seen that the value between the active learning strategy of the Every One Is Teacher Here (ETH) type on learning outcomes at Muhammadiyah At Taqwa Tebing Tinggi Private Middle School is 39.69%.
Analysis of Tempe Tofu Home Industry Standards on Occupational Safety Health (K3) Aspects in Purwodadi Village, Kuala Pesisir District, Naga Raya Regency
Authors: Rizqi Muhammad , Zakiyuddin Zakiyuddin
Published: May 2023

Tofu and tempeh are foods derived from a variety of processed soybeans which have been famous foods among the public for a long time because the tariffs are relatively affordable and widely consumed by the public from various groups. Its existence has long been known and recognized as a healthy and nutritious food. A micro and macro industrial business must have K3 guidelines and K3 standards, although micro-enterprises such as tempeh tofu must also have standards that have been set Industrial work standards which refer to the K3 Law regarding K3 standards. This study focuses on analyzing the standards of the tempeh tofu home industry on occupational safety health (K3) aspects in Purwodadi village, Kuala Pesisir district, Naga Raya regency. This research describes a qualitative type of research. The sample in the study consisted of 14 informants accumulatively broken down from 7 main informants and 7 transmission informants. The measuring equipment used is in the form of literature studies, observations and interview guidelines. The data were analyzed using qualitative analysis whose results were presented in the form of a narrative( descriptive). The results of the study showed that applying assessment standards to buildings has not met the qualifications of businessworthy buildings. Conclusions of the study; each business is required to apply home industry standards and K3 aspects so that work productivity is good and guaranteed from work accidents.
INCREASING AWARENESS OF CHRONIC DISEASE SUFFERERS IN PARTICIPATING IN THE PROLANIS ACTIVITY PROGRAM AT THE MEUREUBO HEALTH CENTER, WEST ACEH REGENCY
Authors: Wizra Lutia
Published: May 2023

This survey was conducted at the Meureubo Health Center in West Aceh Regency with the aim of seeing the increase in awareness of prolanis sufferers at the Meureubo Health Center in West Aceh Regency in participating in the prolanis activity program. Awareness for people with chronic diseases is very necessary to do so as not to cause complications, by following prolanis. BPJS Kesehatan has also implemented a chronic disease management program (prolanis) for the management of hypertension and type 2 diabetes mellitus. Since 2014. In 2021 the Meureubo Health Center has 217 people with hypertension and type 2 diabetes mellitus, with 32 patients, plus in 2022 the disease hypertension to 543 patients. The purpose of this study was to determine the increase in awareness of chronic disease sufferers in participating in the Prolanis program organized by BPJS Kesehatan Meulaboh Branch and run by the Meureubo Health Center. This type of research is a case study qualitative research design (case study).
IMPLEMENTATION OF TOURISM VILLAGE POLICY IN AGUSEN VILLAGE, GAYO LUES REGENCY
Authors: Sufi Sufi , Iryani Lisa
Published: May 2023

This study aims to describe the implementation of the Qanun policy of Gayo Lues Regency Number 4 of 2016 concerning tourism, one of its contents is about the development, management and services of tourism that must be developed. One of them is the Agusen tourist village, which is located in Agusen village, Blangkejeren sub-district, the development which is still not optimal is a serious problem for the Gayo Lues district government to develop this Agusen tourist village. As for the focus of research from the implementation of local government policies regarding the Agusen tourism village, it focuses on communication, resources, disposition of implementers, bureaucratic structure and obstacles faced by local governments in the development and development of the Agusen tourism village object. This research uses qualitative methods using data collection techniques by observation, interviews and documentation. From the results of the study, it can be concluded that the communication that exists between the Gayo Lues district tourism office and the Agusen village government is going well, but the communication carried out with the Agusen village community does not go as desired, the implementation resources in development and development involve several related parties such as the local government agency. tourism in the Gayo Lues district, the Agusen village government, visitors, and the Agusen village community, the obstacles faced from the implementation of this policy are the lack of public awareness of the importance of developing this Agusen tourist village, and the lack of budget to develop and build this tourism object. The suggestion is that the local government and the Agusen village community work together to develop this Agusen tourist village both in terms of infrastructure, services and human resources.
FACTORS RELATED TO THE INCIDENCE OF ASPHYCIA IN NEW BORN INFANTS AT RSUD SUBULUSSALAM CITY
Authors: Putri Mika Hutari Ningsih  , Marniati  , Dian Fera  , Susy Sri Wahyuni
Published: May 2023

Asphyxia in newborns is a condition where the baby cannot breathe spontaneously and regularly immediately after birth. Data from Subulussalam City Hospital in 2021 there are 19 cases of newborn deaths with 8 cases of asphyxia. The purpose of this study was to analyze the factors associated with the incidence of asphyxia in newborns at Subulussalam City Hospital. In this study using a type of quantitative research with cross sectional design. The location of this research was carried out at the Subulussalam City Hospital, to be precise, in the perinatology room. This research was carried out in January-November 2022. The sample in this study was 34 respondents using the total sampling technique. The types of data used are primary data and secondary data. The results of the study showed that out of 34 cases of asphyxia, p=0.006 for maternal age, p=0.015 for gestational age, p=0.039 for normal weight, p=0.063 for infant condition, p value <0.05) meaning that there is a relationship between maternal age, gestational age, birth weight with the incidence of asphyxia in newborns at Subulussalam City Hospital. The conclusion from the results of the research carried out at Subulussalam City Hospital, it can be concluded that the p-value <0.05 has a significant relationship to the incidence of asphyxia in newborns which has been tested based on the chi square test SPSS analysis. It is recommended that it is necessary to increase socialization by health workers to mothers regarding diseases and complications that can arise during pregnancy, childbirth and postpartum as a preventive measure against the occurrence of asphyxia in newborns.
THE INFLUENCE OF BRAND IMAGE ON CONSUMER SATISFACTION WITH PURCHASING DECISIONS AS INTERVENING VARIABLES (Case Study on Students of STIE Bina Karya Kota Tebing Tinggi)
Authors: Benhart Nainggolan
Published: May 2023

This study aims to determine " The Influence of Brand Image on Consumer Satisfaction with Purchasing Decisions as Intervening Variables (Case Study on Students of STIE Bina Karya Kota Tebing Tinggi)". The method of determining the sample used in this study is to use a saturated sampling technique of 57 samples which are students of STIE Bina Karya Kota Tebing Tinggi users of Honda Scoppy. Based on the results of the analysis of hypothesis 1, it can be concluded that the first hypothesis is accepted, meaning that the Brand Image variable (X) affects the Purchase Decision variable (Z). Based on the results of the analysis of hypothesis 2, it can be concluded that the second hypothesis is accepted, meaning that the Brand Image variable (X) has no effect on the Consumer Satisfaction variable (Y). Based on the results of the analysis of hypothesis 3, it can be concluded that the third hypothesis is accepted, meaning that the Purchase Decision variable (Z) has an effect on the Consumer Satisfaction variable (Y). Based on the results of the analysis of hypothesis 4, it shows that the indirect effect of Brand Image (X) on Consumer Satisfaction (Y) through Purchase Decision (Z) is accepted rather than the direct influence of Brand Image (X) on Consumer Satisfaction (Y).