bluuebunny/crossref_metadata_2025 huggingface dataset:
Role of Teacher’s Sensitization Program for the Mental Well-Being of Students: A Study of Government School Teachers in India
Authors: Siraj Sabreen , Bali Shruti , Naval Neemisha , Taneja Deepali
Published: September 2024

The mental well-being of individuals is as important as their physical health, contributing to their overall quality of life. It is, however, often neglected due to associated stigma, with people silently suffering from mental health challenges. In India, a large population is struggling with mental health concerns, especially teenagers and adolescents. With a population of around 1.4 billion, India faces an immense shortage of adequate mental health services, realizing the need for alternate strategies to fill the treatment gap. As teachers spend much time with students in school, they can contribute to their mental well-being if provided with capacity-building opportunities. This study aims to measure the impact of a teacher sensitization program in Indian government schools on mental health-related knowledge, beliefs, and the behaviours demonstrated by them in the classroom while interacting with children, creating a ripple effect towards students’ mental well-being. A total of 136 teachers who were teaching at government high schools in the district of Varanasi, Uttar Pradesh, India, were included in the study. The study used a pre- and post-design to investigate the impact of a teacher sensitization program on their understanding related to mental health. The results indicated notable improvements in teachers' attitudes and beliefs toward mental well-being, with significant improvements observed in areas such as behaviour, teachers' body language, relationships with students, and the use of effective teaching strategies. The findings highlight the importance of professional development initiatives to equip teachers with the skills to effectively support student well-being.
Influence of sarcopenia and frailty in the management of elderly patients with acute appendicitis
Authors: Fransvea Pietro , Chiarello Maria Michela , Fico Valeria , Cariati Maria , Brisinda Giuseppe
Published: September 2024

In developed countries, the average life expectancy has been increasing and is now well over 80 years. Increased life expectancy is associated with an increased number of emergency surgical procedures performed in later age groups. Acute appendicitis is one of the most common surgical diseases, with a lifetime risk of 8%. A growing incidence of acute appendicitis has been registered in the elderly population and in the oldest groups (> 80 years). Among patients > 50-year-old who present to the emergency department for acute abdominal pain, 15% have acute appendicitis. In these patients, emergency surgery for acute appendicitis is challenging, and some important aspects must be considered. In the elderly, surgical treatment outcomes are influenced by sarcopenia. Sarcopenia must be considered a precursor of frailty, a risk factor for physical function decline. Sarcopenia has a negative impact on both elective and emergency surgery regarding mortality and morbidity. Aside from morbidity and mortality, the most crucial outcomes for older patients requiring emergency surgery are reduction in function decline and preoperative physical function maintenance. Therefore, prediction of function decline is critical. In emergency surgery, preoperative interventions are difficult to implement because of the narrow time window before surgery. In this editorial, we highlight the unique aspects of acute appendicitis in elderly patients and the influence of sarcopenia and frailty on the results of surgical treatment.
Evaluation of the mental health of COVID-19 patients discharged from the intensive care unit
Authors: Sarac Elif
Published: September 2024

In this editorial, I address the mental health status of patients who have been discharged from intensive care units (ICUs) after battling coronavirus disease 2019 (COVID-19). An ICU admission is generally a stressful experience, and for severe COVID-19 survivors prolonged treatment in the ICU can lead to significant psychological consequences. These individuals may experience psychiatric distress, including symptoms such as insomnia, anxiety, depression, and even post-traumatic psychological issues. Research indicates that during the first 6 months to 1 year following an ICU stay, nearly one-third of survivors exhibit symptoms similar to those of depression and post-traumatic stress disorder. Several factors may have contributed to the development of depressive and anxious symptoms during the COVID-19 pandemic, particularly for those who underwent an ICU stay. The ICU environment itself is inherently stressful, filled with the constant noise of various medical devices. Studies have provided strong evidence that the prolonged need for ventilation support and the loss of freedom of movement are key factors in the development of psychological problems among COVID-19 patients who had been treated in the ICU.
Infection with Listeria monocytogenes meningoencephalitis: A case report
Authors: Xu Da-Zhen , Tan Quan-Hui
Published: September 2024

BACKGROUND

Listeria meningitis is an infectious disease of the central nervous system caused by Listeria monocytogenes . This bacterium is widely present in the natural environment and can be transmitted through channels such as food and water. Patients usually show symptoms such as fever, headache, and neck stiffness. In severe cases, coma, convulsions, or even death may occur. Traditional diagnostic methods, such as cerebrospinal fluid (CSF) culture and serological tests, have certain limitations. Although CSF culture is the “gold standard” for diagnosis, it is time-consuming and has a relatively low positivity rate. Serological detection may also result in false positive or false negative results. The emergence of metagenomic sequencing (mNGS) technology has led to a significant breakthrough in diagnosing Listeria meningitis, allowing quick and accurate detection of various pathogens in samples.

CASE SUMMARY

Here, we present the case of a previously healthy 64-year-old woman diagnosed with Listeria meningitis using mNGS. She was successfully treated with intravenous ampicillin and meropenem, without any complications.

CONCLUSION

Listeria meningitis must be considered, especially in patients who fail to show improvement with first-line antibiotic treatments. mNGS significantly reduces the diagnosis time, supporting timely treatment of patients.
Factors predicting access to medications for opioid use disorder for housed and unhoused patients: A machine learning approach
Authors: Esguerra Aaron , Weinandy Thomas J.
Published: September 2024

Background

Opioid use disorder (OUD) is a growing public health crisis, with opioids involved in an overwhelming majority of drug overdose deaths in the United States in recent years. While medications for opioid use disorder (MOUD) effectively reduce overdose mortality, only a minority of patients are able to access MOUD; additionally, those with unstable housing receive MOUD at even lower rates.

Objective

Because MOUD access is a multifactorial issue, we leverage machine learning techniques to assess and rank the variables most important in predicting whether any individual receives MOUD. We also seek to explain why persons experiencing homelessness have lower MOUD access and identify potential targets for action.

Methods

We utilize a gradient boosted decision tree algorithm (specifically, XGBoost) to train our model on SAMHSA’s Treatment Episode Data Set-Admissions, using anonymized demographic and clinical information for over half a million opioid admissions to treatment facilities across the United States. We use Shapley values to quantify and interpret the predictive power and influencing direction of individual features (i.e., variables).

Results

Our model is effective in predicting access to MOUD with an accuracy of 85.97% and area under the ROC curve of 0.9411. Notably, roughly half of the model’s predictive power emerges from facility type (23.34%) and geographic location (18.71%); other influential factors include referral source (6.74%), history of prior treatment (4.41%), and frequency of opioid use (3.44%). We also find that unhoused patients go to facilities that overall have lower MOUD treatment rates; furthermore, relative to housed (i.e., independent living) patients at these facilities, unhoused patients receive MOUD at even lower rates. However, we hypothesize that if unhoused patients instead went to the facilities that housed patients enter at an equal percent (but still received MOUD at the lower unhoused rates), 89.50% of the disparity in MOUD access would be eliminated.

Conclusion

This study demonstrates the utility of a model that predicts MOUD access and both ranks the influencing variables and compares their individual positive or negative contribution to access. Furthermore, we examine the lack of MOUD treatment among persons with unstable housing and consider approaches for improving access.
Cost-utility analysis of proton beam therapy for locally advanced esophageal cancer in Japan
Authors: Sawada Takuya , Kondo Masahide , Goto Masaaki , Murakami Motohiro , Ishida Toshiki , Hiroshima Yuichi , Hoshi Shu-Ling , Okubo Reiko , Okumura Toshiyuki , Sakurai Hideyuki
Published: September 2024

Purpose

Proton beam therapy (PBT) has recently been included in Japan’s health insurance benefit package for certain cancer types. This study aimed to determine the cost-effectiveness of PBT as a replacement for conventional three-dimensional conformal radiotherapy (3D-CRT) for locally advanced esophageal cancer (LAEC) that is not covered by social insurance.

Methods

We estimated the incremental cost-effectiveness ratio (ICER) of PBT as a replacement for 3D-CRT, using clinical evidence from the literature and expert opinions. We used an economic model, decision tree, and Markov model to illustrate the courses followed by patients with LAEC. Effectiveness was estimated as quality-adjusted life years (QALY) using utility weights for the health state. Social insurance fees were calculated as costs. We assumed two base cases depending on the two existing levels of fees for PBT in social insurance: 2,735,000 Japanese yen (US$20,652) or 1,600,000 yen (US$13,913). The stability of the ICER against these assumptions was appraised using sensitivity analysis.

Results

The effectiveness of PBT and 3D-CRT was 2.62 and 2.51 QALY, respectively. The estimated ICER was 14,025,268 yen (US$121,958) per QALY for the higher fee level and 7,026,402 yen (US$61,099) for the lower fee level. According to the Japanese threshold for cost-effectiveness of anticancer therapy of 7,500,000 yen (US$65,217) per QALY gain, the inclusion of PBT for LAEC in the benefit package of social insurance is cost-effective if a lower fee is applied.

Conclusion

PBT is a cost-effective alternative to 3D-CRT for LAEC and making it available to patients under social insurance could be justifiable.
Quantitative chest computed tomography predicts mortality in systemic sclerosis: A longitudinal study
Authors: Amorim Fernanda Godinho , dos Santos Ernandez Rodrigues , Yuji Verrastro Carlos Gustavo , Kayser Cristiane
Published: September 2024

Objective

Quantitative chest computed tomography (qCT) methods are new tools that objectively measure parenchymal abnormalities and vascular features on CT images in patients with interstitial lung disease (ILD). We aimed to investigate whether the qCT measures are predictors of 5-year mortality in patients with systemic sclerosis (SSc).

Methods

Patients diagnosed with SSc were retrospectively selected from 2011 to 2022. Patients should have had volumetric high-resolution CTs (HRCTs) and pulmonary function tests (PFTs) performed at baseline and at 24 months of follow-up. The following parameters were evaluated in HRCTs using Computer-Aided Lung Informatics for Pathology Evaluation and Rating (CALIPER): ground glass opacities, reticular pattern, honeycombing, and pulmonary vascular volume. Factors associated with death were evaluated by Kaplan‒Meier survival curves and multivariate analysis models. Semiquantitative analysis of the HRCTs images was also performed.

Results

Seventy-one patients were included (mean age, 54.2 years). Eleven patients (15.49%) died during the follow-up, and all patients had ILD. As shown by Kaplan‒Meier curves, survival was worse among patients with an ILD extent (ground glass opacities + reticular pattern + honeycombing) ≥ 6.32%, a reticular pattern ≥ 1.41% and a forced vital capacity (FVC) < 70% at baseline. The independent predictors of mortality by multivariate analysis were a higher reticular pattern (Exp 2.70, 95%CI 1.26–5.82) on qCT at baseline, younger age (Exp 0.906, 95%CI 0.826–0.995), and absolute FVC decline ≥ 5% at follow-up (Exp 15.01, 95%CI 1.90–118.5), but not baseline FVC. Patients with extensive disease (>20% extension) by semiquantitative analysis according to Goh’s staging system had higher disease extension on qCT at baseline and follow-up.

Conclusion

This study showed that the reticular pattern assessed by baseline qCT may be a useful tool in the clinical practice for assessing lung damage and predicting mortality in SSc.
Qili Qiangxin capsule attenuates myocardial fibrosis by modulating collagen homeostasis post-infarction in rats
Authors: Sun Minyan , Liu Chunhua , Gao Kehan , Xu Xingming , Chen Kunhan , Qiu Liang , Wang Xiaomin
Published: September 2024

Myocardial fibrosis (MF) is a major cause of morbidity and mortality worldwide. Qili Qiangxin capsule (QLQX) is a traditional Chinese medicine (TCM) formula used for treating MF, QLQX can affect ventricular remodeling by regulating collagen deposition; however, the specific mechanism by which QLQX modulates collagen homeostasis remains unclear. Thus, this study aimed to explore the effect of QLQX on collagen fibers and its mechanism of action in rats after myocardial infarction (MI). Rats were subjected to left anterior descending artery ligation and then were divided equally into five groups: sham, model, low-dose QLQX, high-dose QLQX and empagliflozin groups. QLQX treatment for 28 days significantly improved cardiac function, as evidenced by decreases in heart mass index, cardiac volume, left ventricular end-diastolic diameter, left ventricular end-systolic diameter, N-terminal B-type natriuretic peptide levels, and high-sensitivity cardiac troponin I levels and increases in left ventricular ejection fraction and left ventricular fraction shortening. Hematoxylin and eosin, Masson, and Picrosirius red staining under a light microscope indicated that QLQX treatment suppressed fibrosis and promoted angiogenesis by decreasing the protein expression levels of proteins related to cardiac remodeling including transforming growth factor-β1, metalloproteinase-9 and α-smooth muscle actin and increasing the expression of tissue inhibitor of matrix metalloproteinase-1 concentration. Picrosirius red staining under the polarized light microscope and western blotting showed that MI increased the contents of collagen I and III, and reduced the contents of collagen II and IV. QLQX treatment improved cardiac function and attenuated MF by modulating collagen homeostasis and promoting angiogenesis. This study provides novel insights into the mechanism of action of QLQX in preventing MF after MI.
Randomized controlled trial of an Internet-of-Medical-Things device for patient-guided anorectal biofeedback therapy
Authors: Zhou Jerry , Javadi Bahman , Ho Vincent
Published: September 2024

Biofeedback therapy is useful for treatment of functional defecation disorders but is not widely available and is labor intensive. We developed an Internet-of-Medical-Things (IoMT) device, enabling self-guided biofeedback therapy. This study assesses the safety and efficacy of self-guided biofeedback therapy using the IoMT device in comparison to standard operator-led therapy. Patients experiencing urge or seepage fecal incontinence (≥1 episode/week) were randomly assigned to either our IoMT system or to the conventional anorectal manometry-based therapy. Both interventions comprised six weekly sessions, focusing on enhancing anal strength, endurance, and coordination. The novel device facilitated self-guided therapy via visual instructions on a companion app. Primary outcomes included safety/tolerability, changes in Vaizey severity scores, and alterations in anorectal pressure profiles. Twenty-five patients (22 females, 3 males) participated, with 13 in the novel device group and 12 in the standard therapy group. Both groups showed significant reductions in symptom severity scores: IoMT device group -4.2 (95% CI: -4.06, -4.34, p = 0.018), and the standard therapy group -4.8 (95% CI: -4.31, -5.29, p = 0.028). Anal sphincter resting pressure and sustained squeeze time improved significantly in both groups, and the novel device group demonstrated an increase in maximum sphincter squeeze pressure. There were no significant differences between the therapy groups. Importantly, the experimental device was well-tolerated compared with standard therapy, with no serious adverse events observed. This study demonstrates the comparable efficacy of self-administered biofeedback using the IoMT device with traditional biofeedback therapy. The results demonstrates the potential of the IoMT device as a safe, self-guided method for FI therapy, offering convenience and effectiveness in fecal incontinence management.
Molecular characterization, virulence and antimicrobial and biocidal susceptibility of selected bacteria isolated from the cloaca of nestling ospreys (Pandion haliaetus) from Mono Lake, California, USA
Authors: Loncaric Igor , Szostak Michael P. , Cabal-Rosel Adriana , Grünzweil Olivia M. , Riegelnegg Alina , Misic Dusan , Müller Elke , Feßler Andrea T. , Braun Sascha D. , Schwarz Stefan , Monecke Stefan , Ehricht Ralf , Ruppitsch Werner , Spergser Joachim , Lewis Ashli , Bloom Peter H. , Saggese Miguel D.
Published: September 2024

In the present study, the presence of the Enterobacterales, Staphylococcus spp., Mammaliicoccus spp., and Enterococcus spp. in cloacal samples of nestling ospreys (Pandion haliaetus), a fish-eating specialist, from Mono Lake, California, USA was examined by a multiphasic approach, including antimicrobial and biocide susceptibility testing, genotyping, and whole genome sequencing of selected isolates. The most commonly detected species was Escherichia coli, followed by Mammaliicoccus sciuri, Staphylococcus delphini, Enterococcus faecalis, Enterococcus faecium, Hafnia alvei, Klebsiella pneumoniae, Citrobacter braakii and single isolates of Edwardsiella tarda, Edwardsiella albertii, Klebsiella aerogenes, Plesiomonas shigelloides and Staphylococcus pseudintermedius. Multi-drug resistance (MDR) was observed in two E. coli isolates and in an Enterococcus faecium isolate. The MDR blaCTX-M-55-positive E. coli belonged to the pandemic clone ST58. The results of the present study suggest that nestling ospreys are exposed to MDR bacteria, possibly through the ingestion of contaminated fish. Ospreys may be good biosentinels for the presence of these microorganisms and antibiotic resistance in the local environment and the risk for other wildlife, livestock and humans.
‘Surrender is not an option’: Answers of the Serbian metal scene to the COVID-19 crisis
Authors: Radovanović Bojana
Published: September 2024

This article deals with the Serbian metal scene during the COVID-19 pandemic. To introduce the general features of this small-scale scene, a short historical overview is given, with particular attention to the challenges and opportunities the scene faced during the last decade before the pandemic. This made a good interlude into the scene’s ways of navigating the pandemic, particularly from March 2020 to the beginning of 2022. Within this timeframe, two subdivisions are noticeable: the one mainly marked by the online activity of metal musicians, and the one when live events started happening again, but with restrictions. Relying on online sources such as metal news portals, bands’ pages and profiles, and general news coverage, I will look into the concert activity, new music production and underground media coverage in order to deduce the pandemic outcome for the Serbian metal scene.
A post-pandemic survey of the Istanbul metal scene: Dorock and tribute bands
Authors: Çelikel Hale Fulya
Published: September 2024

This article explores the post-pandemic evolution of the Istanbul metal scene, focusing on Dorock Heavy Metal Club and the surge of tribute bands within the context of Turkey’s political, social and economic upheavals. Drawing on participant observation and interviews with key protagonists, including metal musicians, scene organizers and dedicated metalheads, the study investigates the impact of increased authoritarianism, economic instability and rising Islamic conservatism on the metal subculture. The findings reveal how Dorock has adapted to these challenges, reasserting its role as a central venue for live metal music. Additionally, the article examines the economic factors contributing to the popularity of tribute bands, which have become a financially viable alternative for live performances in a strained economy. This research highlights the resilience and adaptability of the Turkish metal community, illustrating how it continues to thrive despite significant sociopolitical and economic pressures.
Human-Robot Interaction and Social Robot: The Emerging Field of Healthcare Robotics and Current and Future Perspectives for Spinal Care
Authors: Han In Ho , Kim Dong Hwan , Nam Kyoung Hyup , Lee Jae Il , Kim Kye-Hyung , Park Jong-Hwan , Ahn Ho Seok
Published: September 2024

Recent advances in robotics technology and artificial intelligence (AI) have sparked increased interest in humanoid robots that resemble humans and social robots capable of interacting socially. Alongside this trend, a new field of robot research called human-robot interaction (HRI) is gaining prominence. The aim of this review paper is to introduce the fundamental concepts of HRI and social robots, examine their current applications in the medical field, and discuss the current and future prospects of HRI and social robots in spinal care. HRI is an interdisciplinary field where robotics, AI, social sciences, design, and various disciplines collaborate organically to develop robots that successfully interact with humans as the ultimate goal. While social robots are not yet widely deployed in clinical environments, ongoing HRI research encompasses various areas such as nursing and caregiving support, social and emotional assistance, rehabilitation and cognitive enhancement for the elderly, medical information provision and education, as well as patient monitoring and data collection. Although still in its early stages, research related to spinal care includes studies on robotic support for rehabilitation exercises, assistance in gait training, and questionnaire-based assessments for spinal pain. Future applications of social robots in spinal care will require diverse HRI research efforts and active involvement from spinal specialists.
STM2457 Inhibits METTL3-Mediated m6A Modification of miR-30c to Alleviate Spinal Cord Injury by Inducing the ATG5-Mediated Autophagy
Authors: Chen Gang , Shangguan Zhitao , Ye Xiaoqing , Chen Zhi , Li Jiandong , Liu Wenge
Published: September 2024

Objective: The study aimed to investigate the role of N6-methyladenosine (m6A) modification in spinal cord injury (SCI) and its underlying mechanism, focusing on the interplay between m6A methyltransferase-like 3 (METTL3), miR-30c, and autophagy-related proteins.Methods: An SCI model was established in rats, and changes in autophagy-related proteins, m6A methylation levels, and miR-30c levels were analyzed. Hydrogen peroxide (H2O2)-stimulated spinal cord neuron cells (SCNCs) were used to assess the impact of METTL3 overexpression. The effects of STM2457, an antagonist of METTL3, were evaluated on cell viability, apoptosis, and autophagy markers in H2O2-stimulated SCNCs.Results: In the SCI model, decreased levels of autophagy markers and increased m6A methylation, miR-30c levels, and METTL3 were observed. Overexpression of METTL3 in SCNCs led to reduced cell viability, increased apoptosis, and suppressed autophagy. Conversely, co-overexpression of autophagy-related protein 5 (ATG5) or miR-30c inhibition reversed these effects. Knocking out METTL3 yielded opposite results. STM2457 treatment improved cell viability, reduced apoptosis, and upregulated autophagy markers in SCNCs, which also enhanced functional recovery in rats as measured by the Basso-Beattie-Bresnahan score and inclined plate test.Conclusion: STM2457 alleviated SCI by suppressing METTL3-mediated m6A modification of miR-30c, which in turn induces ATG5-mediated autophagy. This study provides insights into the role of m6A modification in SCI and suggests a potential therapeutic approach through targeting METTL3.
Magnetic Resonance Imaging-Based Vertebral Bone Quality Score for Prediction of Cage Subsidence and Screw Loosening in Patients Undergoing Degenerative Lumbar Surgery: A Meta-analysis
Authors: Hu Fangke , Xue Lu , Zhao Dong , Chen Chao , Jing Feng , Yang Qiang
Published: September 2024

Objective: Poor bone quality is a risk factor for postoperative complications after degenerative lumbar fusion surgery. The magnetic resonance imaging-based vertebral bone quality (VBQ) score is a good tool for assessing bone quality, and this is the first meta-analysis performed to summarize the predictive value of the VBQ score for cage subsidence and screw loosening in patients undergoing degenerative lumbar surgery.Methods: Studies were comprehensively searched in electronic databases. The quality of the studies was assessed. The pooled sensitivity, specificity and summary receiver operating characteristic curve were calculated. Publication bias was assessed and meta-regression was conducted.Results: We ultimately included 9 studies with a total of 1,404 patients with a mean age of 60.4 years and a percentage of females of 57.0%. According to the QUADAS-2 (Quality Assessment of Diagnostic Accuracy Studies 2) tool to assess methodological quality, the quality of the included studies was relatively low and risks of bias might exist. Results showed that a high VBQ was significantly associated with cage subsidence and screw loosening, and risk factor analysis revealed that the merged odds ratio was 5.37 for cage subsidence and 3.87 for screw loosening. With a VBQ cutoff value of 3.34±0.45, the pooled sensitivity and specificity for the diagnosis of postoperative complications were 0.75 and 0.75, respectively, and the area under the curve was 0.82 (95% confidence interval, 0.78–0.85).Conclusion: A high VBQ was associated with a high risk of cage subsidence and screw loosening in patients who underwent degenerative lumbar surgery. The VBQ score could be considered for identifying high-risk patients for further evaluation.
Avicennia marina Mangrove Plant Mediated Selenium Nanoparticles and Their Therapeutic Activity Against Oral Pathogens and Other Biological Properties
Authors:   Marine Microbial Research Lab, Department of Research and Analytics (DORA), Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, India, Kamala Kannan
Published: September 2024

In the last few decades nanoparticles are widely used in the control of many pathogenic bacteria, fungi, viruses, and cancer growth both in-vitro and in-vivo. A marine plant of Avicennia marina is widely used in traditional medicine for diabetes, inflammation and skin diseases. Objective: In general Avicennia marina has been used as a traditional medicine to treat various diseases and it has shown significant inhibition against various pathogen and the formation of free radicals. Also, the plant A.marina mediated selenium nanoparticles has therapeutic activity has promising to develop biocompatible new cost effective treatment for various oral diseases. Methods: In the present investigation, we have used A.marina for the green synthesis of SeNPs (selenium nanoparticles) and it was characterized for its surface Plasmon resonance by UV-Vis spectroscopy, morphology analyzed by SEM, elements determined by EDX spectroscopy. Further, functional groups of the SeNPs were determined by FT-IR. Results: The prepared nanoparticles were spherical-shaped withsize ranging 20-60 nm. Subsequent evaluations focused on the antimicrobial potential of the synthesized nanoparticles against common oral pathogens responsible for dental cavities and other oral diseases, encompassing Streptococcus intermedius, Prophyromonas gingivalis, Campylobacter rectus, Fusobacterium nucleatum and Treponema denticola. The SeNPs derived from the marine plant demonstrated both cytotoxic effects and significant zones of inhibition against these oral pathogens. Additionally, these nanoparticles exhibited promising capabilities in scavenging DPPH radicals and displayed anti-inflammatory properties. Conclusion: In light of above-mentioned findings, it can be deduced that SeNP’s synthesized through the mediation of A. marina hold substantial promise for diverse pharmaceutical and medical applications. Clinical relevance: The use of selenium nanoparticles as an antimicrobial agent against dental pathogens has gained significant attention in recent years due to their potential clinical relevance.
Esthetic Management of Maxillary Anteriors with Complicated and Uncomplicated F and Uncomplicated Fractures Using Diff es Using Different Fragment Reattachment Approaches
Authors:   Department of Conservative Dentistry and Endodontics, Dr. Ziauddin Ahmad Dental College and Hospital, Aligarh Muslim University, Aligarh, India, lavanyaashok96@gmail.com, A Lavanya , Kumar Tewari Rajendra ,   Department of Conservative Dentistry and Endodontics, Dr. Ziauddin Ahmad Dental College and Hospital, Aligarh Muslim University, Aligarh, India, lavanyaashok96@gmail.com, Alam Sharique ,   Department of Conservative Dentistry and Endodontics, Dr. Ziauddin Ahmad Dental College and Hospital, Aligarh Muslim University, Aligarh, India, lavanyaashok96@gmail.com
Published: September 2024

Appropriate management of anterior tooth fracture restores the function and aesthetics and provides a positive psychological impact for the patient. One of the most conservative approaches for such a restoration is reattachment; if a fracture fragment remains attached to the tooth and is available, as in young patients, immediate reporting helps preserve the vitality and long-term defense mechanism. Objective: This case report provides two cases with varied approaches for the management of complicated and uncomplicated crown fractures using reattachment procedures. Case report: During the clinical examination, the first case described the management of an uncomplicated fracture using the putty index technique. The second case report describes the management of a complicated fracture of the upper central incisor, which invades the biological width using flap elevation and fiber post-cementation. Conclusion: Fragment reattachment is a reliable, conservative, and immediate alternative technique having better retentive and aesthetic values. Tooth fragment reattachment provides dentists with a conservative approach for an aesthetically satisfactory tooth reconstruction.
Morphology controlled fabrication of porous magnesium oxide nanostructures for the efficient elimination of methyl orange
Authors: Ahmed Saeed , Badsha Mohammad A. H. , Khan Mohammad Ehtisham , Ali Wahid , Mohammad Akbar , Bashiri Abdullateef H.
Published: September 2024

Magnesium oxide-based adsorbents (MGO-A) with different morphologies were synthesized via the hexamethylene tetramine-assisted hydrothermal method. The role of four anions in the reaction system, chloride (Cl⁻), nitrate (NO3
⁻), sulfate (SO4
2⁻), and acetate (C2H3O2
2⁻) was systematically investigated to determine the properties of the MgO. Standard characterization techniques were used, such as X-ray diffraction, scanning electron microscopy, transmission electron microscopy, and surface area and pore size interpretations. The kinetics and adsorption isotherm were studied for removal of the dye methyl orange. The dye’s rapid removal led to equilibrium being reached within 5 min. The correlation coefficient values indicate more applicability of pseudo-second-order kinetics than the pseudo-first-order kinetics. Both physisorption and chemisorption can be a pathway towards successfully removing methyl orange. The adsorption isotherm shows that the maximum capacity of the material is very high, 1,062 mg/g for MGO-A. In light of these results, it appears this material holds promise as a dye removal material.
Long intergenic noncoding RNA for IGF2BP2 stability suppresses gastric cancer cell apoptosis by inhibiting the maturation of microRNA-34a
Authors: Wang Yao , Guo Zhigang , Yang Zhifeng , Deng Qingyan , Huang Yueming , Chen Yanhong
Published: September 2024

The oncogenic role of long intergenic noncoding RNA for IGF2BP2 stability (LINRIS) has been reported in colorectal cancer. This research aimed to study its potential involvement in gastric cancer (GC). In this study, paired GC and non-tumor tissues were obtained from 64 GC patients, and the levels of LINRIS, mature microRNA-34a (miR-34a), and miR-34a precursor in these tissues were measured with RT-qPCR. Linear regression was used to analyze their correlations. The role of LINRIS overexpression and siRNA silencing in regulating the maturation of miR-34a was analyzed by RT-qPCR. Cell apoptosis was studied with flow cytometry. It was observed that LINRIS was overexpressed in GC and showed a negative correlation with mature miR-34a, but not miR-34a precursor. In GC cells, LINRIS siRNA silencing upregulated mature miR-34a level, but not miR-34a precursor level. LINRIS overexpression downregulated miR-34a level. Cell apoptosis analysis showed that LINRIS siRNA silencing and miR-34a overexpression promoted GC cell apoptosis and suppressed cell migration and invasion, while LINRIS overexpression suppressed cell apoptosis and enhanced cell migration and invasion. In addition, the effect of LINRIS overexpression was reversed by miR-34a overexpression. Therefore, LINRIS siRNA silencing in GC may promote cell apoptosis by promoting miR-34a maturation.
Cereibacter sphaeroides ST16 and ST26 were used to solubilize insoluble P forms to improve P uptake, growth, and yield of rice in acidic and extreme saline soil
Authors: Dat Le Tien , Huong Truong Thi Cam , Xuan Ly Ngoc Thanh , Quang Le Thanh , Thao Pham Thi Phuong , Thi Xuan Do , Khuong Nguyen Quoc
Published: September 2024

Soluble phosphorus (P) and P uptake are heavily affected by adverse conditions, such as salinity and acidity. The study aimed to evaluate the effects of P-solubilizing purple nonsulfur bacteria (PSPNSB) Cereibacter sphaeroides on soil characteristics, P uptake, growth, and yield of rice planted in saline soil in Thoi Binh – Ca Mau under greenhouse conditions. The pot experiment was completely randomized in blocks with two factors. Factor A was the rate of phosphorus chemical fertilization at 0, 25, 50, 75, and 100% P according to the recommendation. Factor B was the PSPNSB including a single strain of C. sphaeroides ST16 or C. sphaeroides ST26 and a mixture of them. The soluble P in soil increased by 16.4–18.2% when C. sphaeroides ST16 and ST26 were supplied singly or in the mixture, leading to the increase in total P uptake in rice by 19.2–30.1% in two continuous crops. Moreover, the growth and yield components of rice were also improved, leading to an increase in rice grain yield by 7.20–17.7%. Moreover, supplying the C. sphaeroides strains reduced Na+ in soil and Na content in stem, leaves, and grains, leading to the reduction in proline content in rice. Supplying the C. sphaeroides ST16 and ST26 or their mixture replaced 100% P fertilizer but still ensured the rice grain yield. Further approaches should be made to investigate the possibility of the potent strains replacing chemical P fertilizers under field conditions.
Generalized model of thermoelasticity associated with fractional time-derivative operators and its applications to non-simple elastic materials
Authors: Zakria Adam , Abouelregal Ahmed E. , Atta Doaa , Aleselmi Meshary
Published: September 2024

This study proposes a comprehensive heat conduction model that incorporates fractional time derivatives and two-phase lags to describe the behavior of non-simple thermoelastic materials accurately. Generalized fractional differential operators with non-singular kernels are introduced. This type of fractional derivative includes the Caputo–Fabrizio and the Atangana–Baleanu fractional derivatives. The model also consists of the two-temperature idea, which considers the effect of microstructure through a two-stage delay approach. Interactions of a thermoelastic nature caused by the rapid heating of an isotropic substance under the influence of an external body force were studied as a practical application of the new concept. There has been some discussion about the effect of the discrepancy index and fractional differential operators. Finally, the graphical representations obtained from the numerical simulations were used to explain the behavior of the studied physical fields. The generalized fractional heat transfer model is demonstrated to be capable of producing a temperature forecast that is in close agreement with experimental data. As a result, the proposed model may be useful for solving difficulties in heat transfer, anomalous transport, and other branches of engineering analysis.
The processing and interpretation of sich in German as a second language by Japanese and Korean learners
Authors: Sperlich Darcy
Published: September 2024

This study investigates the processing and interpretation of the reflexive pronoun sich by Japanese and Korean learners of German as a second language. This is explored through the emergentist reflexivity approach, which hypothesizes that these learners will utilize their first language pragmatic strategies to bind sich, instead of syntactic binding found in German. Employing psycholinguistic methodology, a self-paced reading experiment is undertaken, utilizing antecedent judgements and introspective measures. The results show that instead of using the pertinent German syntax to bind sich, the learners continue to fall under the influence of their first language pragmatics. These results are discussed against the larger picture of reflexive theory, showing how German as a second language can advance our understanding of reflexivity.
Ethnopharmacology and current conservational status of Cordyceps sinensis
Authors: Arora Payas , Bahuguna Nikita , Anand Jigisha , Semwal Prabhakar , Rai Nishant
Published: September 2024

Cordyceps sinensis, known as the caterpillar fungus, constitutes an invaluable and irreplaceable part of traditional Chinese medicine (TCM) and is now gaining widespread global recognition and dedicated attention owing to both highly promising characteristics as well as grave dangers that are suggestive of an impending doom. C. sinensis possibly holds the key to the treatment of many human ailments with minimal side effects due to a wide array of biologically active chemical constituents. The powerful potential harbored by this fungus has led to a meteoric rise in its prices in the domestic and international markets which has caused the involvement of an increasing number of harvesters, traders, and buyers and unchecked overexploitation of this bioresource thus threatening its long-term survival in its natural habitat of the Himalayan region. This review focuses on the ethnopharmacology of C. sinensis, and various aspects related to its conservation, such as natural distribution, sale and revenue, decline in population density, and conservational practices prevalent in the current scenario of fungal depletion. The paper concludes with a comprehensive evaluation of the discrete therapeutic capabilities possessed by C. sinensis, the mechanistic insights into the remarkable treatment of chronic ailments using the fungus or its derivatives, and a suggested strategic roadmap that may be adopted for fruitful conservation of this natural miracle.
Penggunaan Pendekatan AIDA sebagai Strategi Promosi pada Media Sosial Instagram ‘oleholehjombangrisell’
Authors: Sri Setyani Nanik
Published: September 2024

Penelitian ini betujuan untuk menjelaskan penerapan model pendekatan AIDA pada penggunaan media sosial Instagram sebagai strategi promosi pada toko Oleh-Oleh Khas Jombang Risell. Penelitian ini mengunakan metode kualitatif dengan pendekatan deskriptif, dimana data yang ditemukan dalam penelitian ini akan di jelaskan sesuai dengan hasil temuan dilapangan. Hasil penelitian menunjukkan bahwa penggunaan Instagram’oleholehjombangrisell’ sebagai strategi promosi ini, dapat bersaing dengan kompetitor. Selain itu adanya promosi yang dilakukan melalui Instagram dapat memperkenalkan produk UMKM yang terdapat di kota Jombang ke semua masyarakat luas (luar kota Jombang). Terdapat beberapa strategi yang dilakukan oleh toko Oleh-Oleh Khas Jombang Risell dalam penggunaan Instagram yaitu dengan menerapkan model pendekatan AIDA. Penggunaan model pendekatan AIDA yang telah diterapkan ini dapat menarik calon konsumen atau follower  untuk mengunjungi dan mengikuti alamat Instagram yang beralamat dari Jombang maupun luar kota Jombang selain itu adanya model pendekatan AIDA yang diterapkan pada konten ini dapat mendorong konsumen untuk melakukan proses pemesanan hingga pembelian.
Atypical presentation of Cushing’s disease with weight loss and hypokalemia
Authors: Badawod Sarah , De Barna , Clarke David B , Imran Syed Ali
Published: September 2024

ACTH-secreting pituitary adenomas causing Cushing’s disease (CD) typically present with weight gain, whereas weight loss and hypokalemia in endogenous Cushing’s patients are suggestive of ectopic ACTH production. We report a case of CD presenting with atypical features of marked weight loss and hypokalemia. A 75-year-old female was admitted to the hospital with a history of profound weight loss, associated with uncontrolled hypertension, hyperglycemia, severe proximal muscle weakness, and hypokalemia. Subsequent investigations, including 24-h urinary free cortisol, 48-h low-dose dexamethasone suppression test, MRI of the sella, and bilateral inferior petrosal sinus sampling, confirmed CD without any evidence of ectopic ACTH production. She became eucortisolemic with medical therapy of ketoconazole and cabergoline, subsequently regained her weight, and became normokalemic. This case illustrates that patients with CD may present with symptoms and biochemical findings that would otherwise suggest ectopic ACTH production.

Learning points

Patients with CD do not always present with classical clinical features and may present with symptoms and biochemical findings that would otherwise suggest ectopic ACTH production.

While most patients with CD typically lose weight after biochemical remission, some patients gain weight after the normalization of cortisol levels.

This case highlights the need to entertain a broad differential in patients presenting with hypokalemia and weight loss and the need to exclude hypercortisolemia.
JUAN ANTONIO MOLINA SERRANO. ACTUAR EN EL PATRIMONIO, INTERVENIR EN EL PASADO
Authors: Ortolano Juan Moreno
Published: September 2024

La creciente y exponencial conciencia patrimonial iniciada en España durante los años ochenta posibilitó un campo abierto de lecturas y acciones en la ciudad que encaminaron la disciplina arquitectónica hacia una sensibilidad más respetuosa con la ciudad histórica. El presente trabajo de investigación busca rastrear y dar cuenta de las operaciones, dentro de ese contexto, llevadas a cabo por el arquitecto Juan Antonio Molina Serrano. Con tal objetivo se analizan, en primera instancia, las condiciones de partida o algunos de los presupuestos teórico-críticos que pudieron haber arropado su trabajo dentro de este campo patrimonial, así como los principales recorridos que se han unido a su actividad proyectual. De este modo, se distinguen tres principales niveles o categorías de intervención: las ‘apropiaciones o matizaciones’, las ‘modificaciones o ampliaciones’ y, por último, aquellas que pretenden ‘trascender el lugar y construir un nuevo lugar’. En su conjunto, pueden entenderse como aclaratorias y como cajas de resonancia de su tiempo y contexto, pero también como personalísimas maneras de operar, a partir de un principio o idea generatriz: construir arquitectura consiste en pensar, antes que nada, en construir un lugar.
EL CONVENT DE SANT DOMINGO D’INCA (MALLORCA). ARQUITECTURA I CERIMONIAL FESTIU ENTRE ELS SEGLES XVII I XVIII
Authors: Bauçà de Mirabò Gralla Concepció
Published: September 2024

El convento de Santo Domingo de Inca se halla reconocido como Bien de Interés Cultural (BIC). A pesar de las transformaciones contemporáneas que ha sufrido y el uso cultural que hoy mantiene, la imagen que proyecta sigue reflejando su origen como fundación dominica (1604-1835).
Hasta ahora, la configuración inicial y la evolución del conjunto conventual se conocían muy poco. El presente estudio documenta las primeras construcciones erigidas a inicios del siglo XVII y reconstruye su desarrollo con datos inéditos procedentes del original archivo dominico, en gran parte extraviado. Aporta una descripción del extenso ceremonial desarrollado con motivo de la colocación de la piedra fundacional del templo actual, que incluyó elementos folclóricos que no se conocían en la localidad de Inca. Todo ello refleja la expansión de las órdenes religiosas durante la Edad Moderna y el contexto del Barroco propio de la Contrarreforma. Además, se explica la evolución del convento en el siglo XVIII, su transformación tras la desamortización, la rehabilitación que lo convirtió en el centro cultural que es actualmente, y se realiza una interpretación estilística de sus elementos fundamentales.
UNA MIRADA A "IMPLOSIÓN": ARTE CONCEPTUAL EN LA COLECCIÓN CGAC (1965-1975)
Authors: Méndez López Nara
Published: September 2024

Con motivo de la efeméride del 30 aniversario del Centro Galego de Arte Contemporánea, este ha acogido Implosión: arte conceptual na colección CGAC (1965-1975), un proyecto comisariado por Pedro de Llano Neira dividido en dos vertientes: una primera formalizada a través de una muestra expositiva, y una segunda organizada en torno a una programación didáctica conformada por visitas comentadas a la exposición por el comisario y un ciclo de mesas redondas orientadas a la reflexión sobre las colecciones confeccionadas desde los museos de arte contemporánea en general y, en particular, sobre la Colección CGAC. Todos ellos, ejercicios destinados a exhortar el inicio de un nuevo ciclo en la institución, marcado por la regeneración de sus líneas de actuación.