bluuebunny/crossref_metadata_2025 huggingface dataset:
Transcription factor binding site clusters identify target genes with similar tissue-wide expression and buffer against mutations
Authors: Lu Ruipeng , Rogan Peter K.
Published: April 2019

Background:The distribution and composition ofcis-regulatory modules composed of transcription factor (TF) binding site (TFBS) clusters in promoters substantially determine gene expression patterns and TF targets. TF knockdown experiments have revealed that TF binding profiles and gene expression levels are correlated. We use TFBS features within accessible promoter intervals to predict genes with similar tissue-wide expression patterns and TF targets using Machine Learning (ML).

Methods:Bray-Curtis Similarity was used to identify genes with correlated expression patterns across 53 tissues. TF targets from knockdown experiments were also analyzed by this approach to set up the ML framework. TFBSs were selected within DNase I-accessible intervals of corresponding promoter sequences using information theory-based position weight matrices (iPWMs) for each TF. Features from information-dense clusters of TFBSs were input to ML classifiers which predict these gene targets along with their accuracy, specificity and sensitivity. Mutations in TFBSs were analyzedin silicoto examine their impact on TFBS clustering and predict changes in gene regulation.

Results: The glucocorticoid receptor gene (NR3C1), whose regulation has been extensively studied, was selected to test this approach.SLC25A32andTANKexhibited the most similar expression patterns toNR3C1. A Decision Tree classifier exhibited the best performance in detecting such genes, based on Area Under the Receiver Operating Characteristic curve (ROC). TF target gene prediction was confirmed using siRNA knockdown, which was more accurate than CRISPR/CAS9 inactivation. TFBS mutation analyses revealed that accurate target gene prediction required  at least 1  information-dense TFBS cluster. 

Conclusions: ML based on TFBS information density, organization, and chromatin accessibility accurately identifies gene targets with comparable tissue-wide expression patterns. Multiple information-dense TFBS clusters in promoters appear to protect promoters from effects of deleterious binding site mutations in a single TFBS that would otherwise alter regulation of these genes.
Thinking Broad and Deep: Why Some Directors Exert an Outsized Influence on Strategic Change
Authors: Lungeanu Razvan , Zajac Edward J.
Published: April 2019

This study addresses the oft-debated questions of whether, when, and how corporate board members help shape firm strategy by advancing a new perspective on heterogeneous director influence that introduces the notion of the deep/broad director. Specifically, we take a sociocognitive and sociopolitical perspective on governance to suggest that deep/broad new outside directors, whose expertise results from a blend of depth and breadth of experience, will have an outsized influence in shaping firm strategy. We test our theory using an extensive multiyear data set that tracks all firms that went through an initial public offering in the United States across multiple business cycles (1997, 2001, and 2004) until 2011. Focusing on new outside directors in their first year of service (and controlling for selection issues), our results support our main prediction that those directors whose prior experiences are both deep and broad are the most influential directors for strategic change. We find this result to be robust for multiple indicators of strategic change. We also explore whether the outsized influence of the deep/broad director on strategic change may vary by differences in a board’s openness to strategic change. We conclude by highlighting the relevance of our approach and findings for future research and debates on director selection and director expertise.

The supplementary file is available at https://doi.org/10.1287/orsc.2018.1258 .
Optimization of conventional treatment of the surface water treatment plant of the city of Khenifra
Authors: Ennouhi Mariem , EL Boukili Abdellah , El Hourch Abderrahim , Guessous Aicha , Khadir Abderrahim , El Otmani Mohamed , Hasnaoui Lahcen , El Azzouzi Mohammed
Published: April 2019

Treatment of the surface water of the city of Khenifra combines a conventional treatment and a membrane process unit (reverse osmosis). The conventional treatment in question uses an aluminium base reagentin the form of Aluminum sulphate that may cause leaks of Aluminum called "residual Aluminum" in the filtered water. The objective of this work is to study the elimination of residual aluminum, resulting from the conventional treatment, for a better operation of the demineralization unit by Reverse Osmosis, located downstream. Indeed, according to the requirements of the supplier of the membranes, the residual aluminum content should not exceed 0.05mg/L. The jar test remains the most used test, at the level of the laboratories, which allows optimizing the doses of treatment reagents to be used in a treatment plant; particularly the aluminum sulfate coagulant. Trials of the jar test were performed and had been optimized by the application of Doehlert experimental design.The effectiveness of the treatment and the optimum conditions through the stages of treatment are achieved by monitoring the parameters: pH, turbidity and residual aluminum.
Magnetically Promoted Rapid Immunofluorescence Staining for Frozen Tissue Sections
Authors: Onishi Tatsuya , Matsuda Sachiko , Nakamura Yuki , Kuramoto Junko , Tsuruma Akinori , Sakamoto Satoshi , Suzuki Shunichi , Fuchimoto Daiichiro , Onishi Akira , Chikaki Shinichi , Kaneko Miki , Kuwahata Akihiro , Sekino Masaki , Yasuno Hiroshi , Hanyu Naohiro , Kurita Tomoko , Takei Hiroyuki , Sakatani Takashi , Taruno Kanae , Nakamura Seigo , Hayashida Tetsu , Jinno Hiromitsu , Kusakabe Moriaki , Handa Hiroshi , Kameyama Kaori , Kitagawa Yuko
Published: April 2019

Current immunohistochemistry methods for diagnosing abnormal cells, such as cancer cells, require multiple steps and can be relatively slow compared with intraoperative frozen hematoxylin and eosin staining, and are therefore rarely used for intraoperative examination. Thus, there is a need for novel rapid detection methods. We previously demonstrated that functionalized fluorescent ferrite beads (FF beads) magnetically promoted rapid immunoreactions. The aim of this study was to improve the magnetically promoted rapid immunoreaction method using antibody-coated FF beads and a magnet subjected to a magnetic field. Using frozen sections of xenograft samples of A431 human epidermoid cancer cells that express high levels of epidermal growth factor receptor (EGFR) and anti-EGFR antibody-coated FF beads, we reduced the magnetically promoted immunohistochemistry procedure to a 1-min reaction and 1-min wash. We also determined the optimum magnetic force for the antibody reaction (from 7.79 × 10−15 N to 3.35 × 10−15 N) and washing (4.78 × 10−16 N), which are important steps in this technique. Furthermore, we stained paraffin-embedded tissue arrays and frozen sections of metastatic breast cancer lymph nodes with anti-pan-cytokeratin antibody-coated FF beads to validate the utility of this system in clinical specimens. Under optimal conditions, this ultra-rapid immunostaining method may provide an ancillary method for pathological diagnosis during surgery. (J Histochem Cytochem 58:XXX–XXX, 2010)
An Unexpected Etiology of Myocardial Ischemia in Young
Authors: Bouomrani Salem , Bouomrani Salem , Souissi Oussema , Guermazi Mouna , Guermazi Mouna , Yahyaoui Souad , Trabelsi Safa
Published: April 2019

Introduction
The cardiac localization of hydatid cyst (HC) is rare and little known. It is exceptionally primary and isolated. Myocardial ischemia remains an exceptional and unusual manifestation of this localization. We report the original observation of cardiac HC revealed by acute myocardial ischemia in a young subject.

Observation
A 35-year-old patient with no notable pathological history was admitted to our department via the emergency room for acute anterior chest pain. The somatic examination was without abnormalities as well as the baseline biological tests. The electrocardiogram demonstrated epicardial ischemia in the infero-lateral territory without other abnormalities. The cardiac troponin I was slightly elevated (32ng/l, N<19ng/l). Subsequent controls after 30min, 60min and 180min did not show significant variations. Subsequent investigations (CT, coro-CT, coronary angiography) led to the diagnosis of intramyocardial HC of the left ventricle, with no abnormalities of the coronary arteries. After surgical excision, the evolution was favorable with normalization of the electrocardiogram and the troponin Ic.

Conclusion
Cardiac localization of this parasitosis is exceptional and characterized by an important clinical polymorphism making its diagnosis a real challenge. It seems useful to discuss the diagnosis of cardiac HC in front of any unexplained electrocardiogram abnormality occurring in endemic zone.
Heart failure and diabetes mellitus: insight into comorbidity
Authors: Petunina Nina A. , Trukhin Ivan V. , Trukhina Liubov V. , Sizova Zhanna M. , Zakharova Valeria L.
Published: April 2019

Diabetes mellitus (DM) and heart failure (HF) are frequent comorbidities with a bidirectional relationship. Patients with HF have increased risk of developing DM, and those with DM are at greater risk of developing HF. HF does not fit clearly into the microangiopathy and macroangiopathy groups. It is known that coronary artery disease and arterial hypertension are the major causes of HF; however, it has been shown that DM can trigger functional and structural abnormalities in the myocardium via diabetic cardiomyopathy, a condition with either restrictive or dilated phenotype. While HF treatment is equally effective and safe in patients with and without DM, this statement is not applicable for antidiabetic treatment. Several antidiabetic drugs, such as rosiglitazone, pioglitazone and saxagliptin increase the risk of hospitalisation for HF, therefore these antidiabetic drugs are contraindicated in patients with DM and HF or patients at risk of developing HF. Despite a large number of clinical evidence, uncertainty about the safety of antidiabetic drugs in patients with HF always exists. In this review, the issues of DM treatment in patients with HF are addressed in detail.
The changes of standard DXA measurements and TBS depending on outcomes of neurosurgical treatment in patients with Cushing's disease
Authors: Tsoriev Timur T. , Belaya Zhanna E. , Chernova Tatiana O. , Sazonova Natalia I. , Hans Didier , Solodovnikov Alexander G. , Mel'nichenko Galina A. , Dedov Ivan I.
Published: April 2019

BACKGROUND: Patients with endogenous hypercortisolism have reduced bone mineral density (BMD) and trabecular bone score (TBS) that are the causes of secondary osteoporosis and low-traumatic fractures. It is well known that radical treatment (neurosurgery or radiosurgery) of Cushing’s disease leads to a decline of cortisol levels in all body fluids to normal values. However, it is still uncertain whether bone tissue structure, and particularly its microarchitecture, does recover in remission of the disease.
AIMS: To evaluate an influence of hormone activity (presence or absence of remission) in patients with Cushing's disease on changes of bone structure measurements in accordance with DXA values (TBS, BMD, T- and Z-scores), as well as significance of such changes in 12 and 24 months after neurosurgical treatment.
MATERIALS AND METHODS: In patients with confirmed active Cushing's disease (ACTH-producing pituitary adenoma) (n = 44) and in control group of healthy volunteers (n = 40), BMD in lumbar spine (L1-L4) and simultaneously TBS, in cut-off points before neurosurgical treatment (in both groups) and in 12 and 24 months after it (only in patients), were assessed. We diagnosed presence or absence of disease remission at cut-offs. All measurements were performed using a GE iDXA device (GE Healthcare Lunar, Madison, Wisconsin, USA). The TBS was calculated simultaneously from taken BMD scans, blinded to clinical outcome using TBS iNsight software v2.1 (Medimaps, Merignac, France). The activity of Cushing’s disease was evaluated using late-night salivary cortisol (LNSC, at 23:00). To determine the differences in DXA and TBS values before and after neurosurgical intervention depending on remission occurrence, covariate analysis (ANCOVA) was applied.
RESULTS: There were found significant changes in TBS, BMD and T-score values in 12 months after neurosurgical treatment associated with presence or absence of disease remission (p = 0.039, 0.046 and 0.048, respectively). No differences in Z-score as well as in all measurements in 24 months, that might be associated with remission occurrence, were revealed. The gain in all DXA measurements (including TBS) during 24 months of observation period was statistically significant when analyzing data using Student’s paired t-test. However, the values corresponding to the age references had not been achieved for the specified time interval.
CONCLUSIONS: Patients with Cushing’s disease have lower TBS values. In remission conditions TBS is getting significantly higher. The increase in BMD and TBS occurs during 24 months after achieving remission of Cushing’s disease but doesn’t lead to a full restoration of normal bone mass and microstructure throughout observation period of 24 months.
Adoption factors to digital TV platforms in Turkey
Authors: Yersel Burçin
Published: April 2019

The main aim of this study is to understand digital TV platform adopters’ media usage and adopting factors by identifying their profile in Turkey. According to this aim, it was tried to find out the demographic characteristics of digital TV broadcasting adopters, media usage level and the factors of adopting. In addition, it was tried to find out demographic variables, media usage frequency differences between adopters of digital TV platform and non-adopters. The result of analysis shows that, while it was found significant differences between adopters’ and non-adopters’ education; was not found significant differences between adopters’ and non-adopters’ age and sex. There is no significant differences between adopters’ and non-adopters’ media uses.  According to the results of factor analysis shows that there are 5 reason to adopting digital TV platform.
Czech Reformational biblical translation: the case of pericopes in the Unity of the Brethren in the 1550s‒1570s
Authors: Dittmann Robert
Published: April 2019

The pericopes in vernacular languages were one of the achievements of the European Reformation. In Bohemian Lands, the pericopes were read in Czech already soon after 1415, namely as a feature of the Hussite movement. Fully Bohemicised liturgy, thus promoting Czech as the first vernacular within the Roman obedience to holy languages, was adopted by the Unity of the Brethren. The development of pericopes within the Unity was dynamic and noteworthy. The study describes and by textual probes illustrates the development of pericopes in the Unity after the reform of Lukas of Prague, which is tightly connected to the most literal Czech biblical translation in the 16th century, published in 1525. In the 1540s, the bishop Jan Augusta attempted at a reform of the pericopal system and in his Summovník he translated pericopes rather literally from Biblia Tigurina. His translation was modified by other Brethren bishops and printed in 1557‒1559. A new revised version came out in 1563 but no copy has survived. In 1571 Blahoslav’s Evanjelia and in 1575 Štefan’s Postil were published, both including pericopes. The study explores in detail the mutual textual relations of these prints.
Psałterz poznański. Prolegomena lingwistyczne
Authors: Nowak-Barcińska Małgorzata
Published: April 2019

This article discusses a collection of fifty psalms published as The Poznań Psalter. A Collection of Psalms for Common Singing at Home and in Church (Poznań 2017). As a text genre, the publication represents a song book, which – according to its dictionary definition – is: ‘a collection of songs (solemn or popular) with their lyrics and notes’. The publication can alternatively be classified as a hymnal. The authors of the paraphrased psalter intended to underscore the musical character of the Biblical texts. This musical character is underscored by giving the particular psalms their regular rhythmic pattern, partly supported with a rhyming pattern. As far as the musical layer of the Poznań Psalter is concerned, the authors make a conscious reference to tradition, since the melodic lines are transferred from the Geneva Psalter (1563 edition). The language layer, on the other hand, departs from tradition, since it does not exhibit the historically marked lexical or grammatical structures. Analysing the text of the Poznań Psalter, composed by the Protestant (Reformed Evangelical Church) authors in the context of the Polish tradition of Biblical translation, one can conclude that this tradition retains its vital interdenominational nature, which – as in the case in point – is capable of using the Warsaw Bible and the Millennium Bible as sources of textual adaptation.
Passivum divinum w Tanachu i Biblii Lutra
Authors: Termińska-Korzon Kamilla , Tobiasz Lesław
Published: April 2019

Passivum divinum is a characteristic of utterances related in an overt, hidden, or presupposed way to divine activities formulated in the passive voice. Passivum divinum emphasizes Divine Agent’s action in utterances that use repetition of particularly sublime structure, and it characterizes divine performative utterances. Passivum is also used to share responsibility with another agent for a particular action of the Divine Initiator, expressing in this way “the idea of G-d’s secretiveness”. Passivum divinum also creates space for action in this “best of all worlds” of evil powers. Since passive grammatical formations in Biblical Hebrew, German, and Polish are differently semanticized, there is possibility of achieving full, either dynamic or formal, translatory equivalence.
Jakim językiem XVI-wieczni pisarze reformacyjni pisali o wychowaniu dzieci (Gliczner, Kwiatkowski, Lorichius)?
Authors: Woźniak Ewa , Gozdek Magdalena
Published: April 2019

The article is devoted to stylistic properties of three pedagogical works that were published in Protestant circles in the 16th century Poland. The first one is the translation from Latin of the treatise written by German Protestant theologian Reinhard Lorichius titled Księgi o wychowaniu i o ćwiczeniu każdego przełożonego (1558), the second one is the Polish publication of Erazm Gliczner’s Książki o wychowaniu dzieci bardzo dobre, pożyteczne i potrzebne (1558) and the third one is the treatise written by the Italian humanist from the 14th and 15th century titled Książeczki rozkoszne a wielmi użyteczne o poćciwym wychowaniu […] dziatek (1564), translated by Marcin Kwiatkowski. The authors of the analysis recognised didacticism, vividness and erudition as the predominant stylistic features of discussed works. They proved that the 16th century books on upbringing of children had been addressed to readers of every denomination and lacked elements of religious polemics on the linguistic and stylistic level. The ideas of the Reformation can be connected mainly with popularization of the Bible, which was used as the source of exempla and sententiae in the works by Lorichius and Gliczner.
Polemika między Starowolskim i Przypkowskim. Przyczynek do badań XVII-wiecznego dyskursu wykluczenia i dyskursu tolerancji
Authors: Hawrysz Magdalena
Published: April 2019

The paper focuses on two types of the 17th century public discourse – of exclusion and tolerance. The research is based on the analysis of the works of Szymon Starowolski (Braterskie napomnienie, Prawdziwe objaśnienie Braterskiego napomnienia) and Samuel Przypkowski (Braterska deklaracyja) which constitute a polemical chain or a series of works combined on the basis of discussion replies. The purpose of the sketch is to characterize the subjects of the discourse, describe the communication strategies used and reconstruct presented attitudes and values. The subject of the discourse of exclusion assumes the approach of a hegemon attempting to discredit the object of the discourse and lead to its isolation. It invokes to insinuation and emotional arguments. The subject of the discourse of tolerance represents an irenic attitude and presents a society based on amicable coexistence, the will of cooperation, respect for law and freedom of conscience.
The impact of thyroid hormone dysfunction on ischemic heart disease
Authors: von Hafe Madalena , Neves João Sergio , Vale Catarina , Borges-Canha Marta , Leite-Moreira Adelino
Published: April 2019

Thyroid hormones have a central role in cardiovascular homeostasis. In myocardium, these hormones stimulate both diastolic myocardial relaxation and systolic myocardial contraction, have a pro-angiogenic effect and an important role in extracellular matrix maintenance. Thyroid hormones modulate cardiac mitochondrial function. Dysfunction of thyroid axis impairs myocardial bioenergetic status. Both overt and subclinical hypothyroidism are associated with a higher incidence of coronary events and an increased risk of heart failure progression. Endothelial function is also impaired in hypothyroid state, with decreased nitric oxide-mediated vascular relaxation. In heart disease, particularly in ischemic heart disease, abnormalities in thyroid hormone levels are common and are an important factor to be considered. In fact, low thyroid hormone levels should be interpreted as a cardiovascular risk factor. Regarding ischemic heart disease, during the late post-myocardial infarction period, thyroid hormones modulate left ventricular structure, function and geometry. Dysfunction of thyroid axis might even be more prevalent in the referred condition since there is an upregulation of type 3 deiodinase in myocardium, producing a state of local cardiac hypothyroidism. In this focused review, we summarize the central pathophysiological and clinical links between altered thyroid function and ischemic heart disease. Finally, we highlight the potential benefits of thyroid hormone supplementation as a therapeutic target in ischemic heart disease.
Las conexiones escenográfico-psicológicas entre Cuando los ángeles caen y La trilogía de apartamentos de Roman Polanski
Authors: Padilla Díaz Alberto Román
Published: April 2019

La gama de géneros con las que ha trabajado el cine de Roman Polanski es tan amplia que cuesta hallar algún estilema que encadene visual y teóricamente su filmografía. Sin embargo, puede que el tratamiento de la escenografía sea dicho elemento unificador. Este escrito indaga sobre esta hipótesis y propone un nombre para este mecanismo cinematográfico: Dispositivo escenográfico-psicológico. El objeto de estudio elegido para ello es el cortometraje Cuando los ángeles caen, que fue realizado antes del debut cinematográfico del director. En él, se propone esta lectura y se establecen conexiones estilísticas con tres películas fundamentales, a nivel escenográfico, de su futura filmografía, conocidas como Trilogía de apartamentos.
Retomando el enfoque de Émile Jaques-Dalcroze en la formación del profesional de la música
Authors: Capistrán-Gracia Raúl Wenceslao
Published: April 2019

A finales de siglo XIX, Émile Jaques-Dalcroze desarrolló un enfoque educativo que tuvo como propósito ayudar a los estudiantes del Conservatorio de Música de Ginebra, Suiza, a vencer los retos técnico-musicales que enfrentaban en su formación profesional. Las áreas de oportunidad que Jaques-Dalcroze observó en sus discípulos hace más de 100 años, son las mismas que muchos estudiantes tienen hoy en día en muchas escuelas de música. Desgraciadamente, a pesar del éxito que alcanzó, en la actualidad el enfoque Jaques-Dalcroze se ha desaprovechado casi por completo en la formación de los estudiantes a nivel superior. En el presente artículo, el autor hace una reflexión sobre la vigencia de este enfoque pedagógico-musical, proporciona una revisión en torno a las enormes aportaciones que hace a la formación del músico profesional y ofrece algunas recomendaciones para su aplicación en las escuelas de música a nivel superior. Finalmente, el autor exhorta a las autoridades y maestros de los conservatorios, facultades y departamentos de música a considerar su incorporación en los planes de estudio como un recurso pedagógico de gran valor.
Estética de la irrupción. Activismo y performance en Las Yeguas del Apocalipsis (Chile 1987-1993)
Authors: Vélez Giraldo Fátima
Published: April 2019

Este trabajo examina los mecanismos estéticos y políticos de uno de los primeros grupos artísticos que politizaron la crisis del VIH/sida en Latinoamérica: el colectivo Las Yeguas del Apocalipsis, conformado en 1987 por Pedro Lemebel y Francisco Casas. A partir de algunas de las obras más significativas del colectivo se explorará la manera en que estas intervenciones dialogan con el activismo cultural, planteado por Douglas Crimp, con el fin de acabar con la epidemia. En el caso de Las Yeguas del Apocalipsis el activismo asume una forma radical que hace posible desde la corporalidad una lucha política, un debate por la salud, la diversidad, pero también una reivindicación de los sujetos marginales. A través del performance esta politización pone en jaque la forma en que se habla en público de la sexualidad y, al mismo tiempo, integra una aguda reflexión sobre dictadura, postdictadura y neoliberalismo, y el control de estas fuerzas sobre los cuerpos no heteronormativos.
Kereskedelmi forgalomban használt D-dimer-tesztek vágóértékének harmonizálása
Authors: Török-Nagy Beáta , Vajda Zoltán , Vásárhelyi Barna
Published: April 2019

Abstract:

Introduction: The objective of the D-dimer tests is to exclude venous thromboembolic disorders. The characteristics of various D-dimer tests differ significantly and consequently, their results are difficult to compare. Aim: Our goal was to compare three D-dimer tests, analyse their correlation and harmonise their sensitivity and specificity through the optimisation of cut-off values. Method: At Semmelweis University, the D-dimer level was determined with three different reagents in 158 plasma samples, suspected with venous thromboembolism. INNOVANCE D-Dimer was selected as the referent, and in the case of the two other tests (STA-Liatest D-Di; Dia-D-Dimer), the cut-off values were changed between 0.2–1 µg/ml (fibrinogen-equivalent unit – FEU). The optimal cut-off values were estimated by diagnostic parameters and chi-square test. The correlation of the different tests was calculated by regression analysis. Results: Based on the chi-square statistics, there is no significant difference between STA-Liatest D-Di and INNOVANCE D-Dimer tests using the cut-off values 0.3–1 µg/ml (FEU) (STA-Liatest D-Di). In the case of Dia-D-DIMER, there is a significant difference using 0.2–0.3 µg/ml (FEU) cut-off values, 0.4 µg/ml (FEU) is a border-line value and using 0.5–1 µg/ml (FEU) cut-off values, there is no significant difference. The sensitivity of STA-Liatest D-Di changed between 82.7–100% using 0.2–1 µg/ml (FEU) cut-off values, while the sensitivity of Dia-D-DIMER was 92.3–100%. Their specificities ranged between 50–96.3% and 35.2–87%. The optimal cut-off values were estimated as 0.5–0.6 µg/ml (FEU) for the STA-Liatest D-Di test and 0.7 µg/ml (FEU) for the Dia-D-DIMER test. Conclusion: Each diagnostic laboratory should determine the optimal cut-off value of the D-dimer test in use, considering the examined population of the area. Orv Hetil. 2019; 160(15): 585–592.
The Effectiveness of Learning Basic Concepts of Art for Primary Teacher Education Students Using Nomor Acak Learning Model
Authors: Zufriady Zufriady , Kurniaman Otang
Published: April 2019

The nomor acak learning model is done by randomly giving number to each student and making them remember it from the beginning to the end of the lecture. The function was to make each student be more active in the teaching and learning activities, since they must be prepared with their respective material if the number was called. This research employed a quasi-experimental research method with one group pre-test/post-test design. The determinant coefﬁcient data of the effect of nomor acak models on the effectiveness of primary teacher education students obtained a class A data of 58.21%, class B of 36% and class C of 23%. This research was conducted at the primary teacher education program for six months in the Basic Concepts of Art courses to students of 2018. It could be concluded that the nomor acak learning model could improve the learning outcomes of students of the primary teacher education program in the Basic Concepts of Art course.
Oleic, palmitic triglycerides, very low density lipoproteins. Atherosclerosis, arterial atheromatosis and ischemic heart disease pathogenesis
Authors: Titov Vladimir N. , Schekotova Alevtina P.
Published: April 2019

In the clinic and experiment, the basic factor in pathogenesis of hyperlipoproteinemia, atherosclerosis and atheromatosis is disturbance of physicochemical parameters of very low density lipoproteins (VLDLP). They are secreted into the blood flow by hepatocytes in biological reaction of exotrophia, external nutrition, biological function of trophology – nutrition. When there are no genetic disorders, VLDLP parameters are determined mainly by substrate induction, realization of biological reaction of exotrophia. Aphysiological induction of substrate is: a) high content of exogenous palmitic saturated fatty acid and palmitic position forms of triglycerides in the food of Homo sapiens, when a patient uses an excessive amount of meat and little carbohydrates for food. We believe that for primary prevention of ischemic heart disease the following is required: a) as for normalization of biological function of endoecology – to reduce the supply of ligandless palmitic low density lipoproteins in the intima and b) to inhibit atheromatosis of elastic type arteries including coronary artery atheromatosis. To inhibit atherosclerosis, it is necessary to normalize the biological function of nutrition, reduce the amount of meat food, replacing it by fish, while increasing the amount of vegetable food according to parameters of general biology. The basic in prevention of atherosclerosis, atheromatosis and IHD, we suppose, is activation of cognitive biological function. This is positioning of organism in the unity of: a) metabolic reactions in vivo b) exposure of environmental factors and c) social conditions, understanding of the fact that in phylogenesis, the species Homo sapiens was formed as herbivorous species with carnivorous (fish-eating) past in the ocean. If there is no critical understanding of the necessity of optimization of biological nutritional function in patients “meat-eaters”, neither prevention of atherosclerosis and atheromatosis, nor treatment of IHD will be successful. Nothing different in biology or medicine is available.
Inflammatory bowel diseases: fertility, pregnancy, labor
Authors: Sandakova Elena A. , Khlynova Olga V. , Zitta Dmitriy V. , Stepina Ekaterina A. , Koposova Ksenia A. , Okisheva Lidia G.
Published: April 2019

Inflammatory bowel diseases (IBD) including ulcerous colitis (UC) and Crohn’s disease (CD) are widely spread among young persons and therefore there are many questions from both patients and specialists regarding management tactics for this category of patients. The paper presents the main items of The Second European Consensus on Reproduction and Pregnancy in Patients with IBD including the questions of fertility, optimization of pregnancy planning, characteristic features of its course, labor and postpartum period.
Immunomodulating effect of magnetoinfrared laser therapy in children with chronic pyelonephritis
Authors: Illek Ya. Yu. , Vyaznikova M. L. , Leushina N. P. , Mischenko I. Yu. , Ryseva L. L. , Solovyova G. V. , Tarasova E. Yu. , Suetina I. G. , Khlebnikova N. V.
Published: April 2019

Aim. To determine the influence of magnetoinfrared laser therapy on the status of immunological reactivity in children with chronic pyelonephritis (CP).

Materials and methods. One hundred thirty children aged 8 to12 years, suffering from relapsing course of chronic pyelonephritis, were observed. Group 1 (43 patients) received complex conventional therapy, group 2 (27 patients) – complex treatment, associated with magnetoinfrared laser therapy. The blood lymphocyte population and subpopulation, blood serum immunoglobulin and circulating immune complexes content, phagocytosis indices, blood serum cytokine content was studied in children with chronic pyelonephritis at the active stage of disease, at the partial and full clinicolaboratory remission stages.

Results. The CP patients of group 1, who received complex conventional therapy, demonstrated a full, but not long clinicolaboratpory remission with preservation of marked changes in immunological reactivity parameters. In CP patients of group 2, who experienced complex treatment associated with magnetoinfrared laser therapy courses, there occurred full clinicolaboratory remission and normalization of immunological reactivity indices.

Conclusions. The results of clinical observations and special studies demonstrate high clinical, immunomodulating and antirelapsing effects of complex treatment combined with magnetoinfrared laser therapy in children with chronic pyelonephritis.
Infant mortality at home in Perm Krai. Main causes and prevention
Authors: Kochergina E. A. , Trefilov R. N. , Blyumberg N. V.
Published: April 2019

Aim. To assess the most frequent causes of infant mortality at home in Perm Krai, to give the main recommendations for its prevention.

Materials and methods. Retrospective study of 165 cases of the death of children under 1 year of age in Perm Krai over the period of 2013-2016 was carried out.

Results. Among the causes of the death of children under 1 year of age at home, the most frequently registered were the following: sudden infant death syndrome (SIDS) – 47.9 %, traumas – 24.8 % and respiratory diseases – 18.8 %. In case of SIDS, the share of premature infants was 16.7 %, more than a half of infants had various signs of morphofunctional immaturity (58.8 %). Mothers’ smoking during pregnancy and after giving birth to a child occurred in 78.6 % of SIDS cases. Half of cases of death at home from traumas in children under age 1 is connected with mechanical asphyxia while sleeping, 33 % – as a result of gastric content aspiration into respiratory tract, 16.7 % – owing to nonobservance of safe conditions of sleep. Infant death in consequence of traumas more often than the other causes of death was accompanied by social risk (75.0 % of cases), regarding SIDS social risk was noted in 66.7 %, acute respiratory diseases – in 50.0 %.

Conclusions. Prevention of the main causes of death at home among infants under 1 year of age consists in a timely detection of prognostic risk and initiation of standard preventing measures.
Local History Collection in Public Libraries of South 24 Parganas: A Study
Authors: Moitra Sudeshna , Dutta Chaitali
Published: April 2019

Public library has the social responsibility to meet the local community requirements for knowledge, information, education, culture, recreation, and so on. The responsibility includes preserving local history materials of a particular locality. This paper reflects the present scenario of collection, preservation, dissemination, use pattern of local history materials and user demand for such collection in the Government-sponsored public libraries (District Library, Sub-divisional Libraries and Town Libraries) in South 24 Parganas district in West Bengal. Every library was visited personally to interview the Librarian/In-charge and data were collected through a structured questionnaire. Library users were also interviewed through a separately structured questionnaire by applying random sampling method. Collected data were analysed to find out the present situation and issues related to building local history collection and rendering effective associated services. Findings reflect the major hindrances responsible for the state of sources of local history in the South 24 Parganas. Some recommendations have been made.
Gastrointestinal Beriberi as a prodrome of non-alcoholic Wernicke’s encephalopathy: a study of an emerging nutritional deficiency disorder from Kashmir, India
Authors: Shah Irfan Ahmad , Kawoos Yuman , Shah Asif Iqbal , Rabyang Stanzen , Naqash Henna , Mir Mohd Rafi
Published: April 2019

Background: Gastrointestinal manifestations of thiamine deficiency have not been well described in literature. Authors aimed to study the symptoms of gastrointestinal beriberi in a cohort of patients of non-alcoholic Wernicke’s encephalopathy and review the relevant literature.Methods: In a retrospective analysis, case records of 52 patients diagnosed with non-alcoholic Wernicke’s encephalopathy were analyzed for the nature of gastrointestinal symptoms, their duration, severity and associated findings, investigations and response to treatment. The available literature on gastrointestinal symptoms in thiamine deficiency disorders and gastrointestinal beriberi was reviewed.Results: Gastrointestinal symptoms were found in 46 of the 52 patients. The most common gastrointestinal symptom in our patients was recurrent vomiting in 42 patients. Eight patients had water brash. Ten patients had epigastric pain and 10 patients had anorexia. Based on the nature and severity of symptoms, patients were evaluated for their symptoms using endoscopy, ultrasonography, amylase and lactate levels, and routine laboratory studies and the results were normal in the majority of patients.  Gastrointestinal symptoms settled in all the patients after receiving intravenous thiamine. On reviewing the literature multiple studies were found to have reported prominent gastrointestinal symptoms in patients of Wernickes encephalopathy and other thiamine deficiency related disorders. However, the definition of gastrointestinal beriberi is not clearly stated.Conclusions: Gastrointestinal symptoms were prominent prodromal manifestations in our cohort of Wernicke’s encephalopathy and have also been amply reported in literature. Presence of gastrointestinal symptoms in individuals predisposed to thiamine deficiency without alternative explanation should be enough to label a patient as gastrointestinal beriberi. The study highlights the importance of recognizing gastrointestinal beriberi as a distinct syndrome that may precede the development of Wernicke’s encephalopathy.
Evaluation of serum gamma-glutamyl transferase and highly sensitive C-reactive protein as biomarkers of oxidative stress and inflammation in type 2 diabetes mellitus patients with good and poor glycemic control
Authors: Krishnamurthy Vishwanath , Patted Arun Sangappa , T. Anil Kumar , Jayaram Sujatha Kuppuswamy , Magaji Bhavana Shree
Published: April 2019

Background: Diabetes mellitus comprises a group of common metabolic disorders which share common phenotype of hyperglycaemia. Oxidative stress and inflammation are associated with poor glycaemic control and further pathogenesis and complications of diabetes mellitus. This study investigated for correlation of good and poor glycaemic control with these factors.Methods: Subjects selected for the study were divide into three groups, group I control (n=35), group II type 2 diabetes mellitus patients with good glycaemic control (n=35) and group III type 2 diabetes mellitus patients with poor glycaemic control (n=35). Patients complete blood count, random blood sugar, HbA1c, HsCRP and GGT were investigated. These parameters were statistically analysed for correlation between HbA1c with GGT and HbA1c with hsCRP.Results: The mean HbA1c in group I, II and III were found to be 5.17%, 6.54% and 9.23% respectively. It was statistically significant (p=0.01), as according to the criteria defined for study recruitment. Furthermore, mean GGT and hsCRP levels were evaluated; a statistically significant difference in mean GGT levels as well as hsCRP of three different groups were obtained with a p value of 0.02. Correlation between HbA1c and hsCRP was found to positive (R2=0.17, p=0.03). When GGT was compared with HbA1c across the groups, there was a statistically significant correlation (R2= 0.09, p=0.03).Conclusions: Present study established a positive correlation between HbA1c and GGT, HbA1c and hsCRP, indicating increasing oxidative stress and inflammation in patients with poor glycaemic control.
ESPIRITUALIDADE E VIDA SIMBÓLICA
Authors: Almeida Júnior José Benedito de
Published: April 2019

Este trabalho tem por objetivo analisar o conceito de “vida simbólica” de Carl Gustav Jung e associá-lo à noção de espiritualidade. Para Jung, o homem moderno vive uma crise espiritual decorrente da perda de sua capacidade de reagir ao numinoso e às forças do inconsciente. A vida simbólica é expressa por meio de rituais religiosos que permitem o fluxo energético gerado pelas pressões comuns do cotidiano. Portanto, a vida simbólica é expressa por meio de símbolos das religiões, ou seja, pelas suas formas de espiritualidade presentes nos ritos coletivos ou privados. Dessa forma, quanto mais rica em símbolos maior é a capacidade de uma religião permitir o equilíbrio das relações entre o ego e o self, bem como, entre a pessoa e a vida comum. Por outro lado, quanto maior a racionalização da religião e a concepção materialista de vida, menos intensa é a vida simbólica e menor a capacidade de reagir às pulsões do inconsciente e das pressões da vida. Nesse sentido, como último recurso, o homem moderno apega-se às formas de espiritualidade superficiais como a literatura de autoajuda, aos hobbies etc.

SPIRITUALITY AND SYMBOLIC LIFE

This work aims to analyze the concept of ‘symbolic life’ of Carl Gustav Jung and associate it with the notion of spirituality. For Jung, modern man experiences a spiritual crisis due to the loss of his ability to react to the numinous and the forces of the unconscious. The symbolic life expressed through religious rituals that allow the energetic flow generated by the pressures of life on the conscience and the unconscious, in other words, expressed through symbols of religions, this is, by their forms of spirituality present in collective or private rites. In this way, as richer in symbols, the greater will be the capacity of religion to balance the relationship between ego and self, as well as between the person and the ordinary life. On the other hand, the greater the rationalization of religion and the materialistic conception of life, the less intense is the symbolic life and the less the ability to react to the drives of the unconscious and the pressures of life. In this sense, as a last resort, modern man clings to superficial forms of spirituality such as self-help literature, hobbies, and so on.
O ROCK COMO POSSIBILIDADE PARA UMA ESPIRITUALIDADE NÃO-RELIGIOSA
Authors: Rodrigues Flávio Lages
Published: April 2019

Este artigo analisa o rock como elemento principal na espiritualidade não-religiosa com o ritual, sentimento de pertencimento, solidariedade e sociabilidade, para além das instituições religiosas. Nossa hipótese parte de que o crescimento das cidades, bem como o pensamento pós-moderno proporcionaram outras formas de cultura e espiritualidade na atualidade. O objetivo principal desse artigo é mostrar que o rock pode ser o elemento socializador principal nessa espiritualidade não-religiosa entre as tribos urbanas headbanger em Belo Horizonte. A metodologia proposta para esse trabalho é constituída por análise da referência bibliográfica e tem como teórico principal o sociólogo Michel Maffesoli entre outros autores.

THE ROCK AS POSSIBILITY FOR A NON-RELIGIOUS SPIRITUALITY

Abstract: This article analyzes rock as the main element in non-religious spirituality with ritual, feeling of belonging, solidarity and sociability, outside of religious institutions. Our hypothesis is that the growth of cities as well as postmodern thought have provided other forms of culture and spirituality today. The main purpose of this article is to show that rock can be the main socializing element in this non-religious spirituality among the urban tribes headbangers in Belo Horizonte. The methodology proposed for this work is constituted by analysis of the bibliographical reference and has as main theoretician the sociologist Michel Maffesoli among other authors.
ESPIRITUALIDADE E MAGIA NAS HISTÓRIAS EM QUADRINHOS DA MARVEL
Authors: Guerriero Silas , Stern Fábio Leandro
Published: April 2019

Nas histórias de super-heróis, a magia é uma constante, muitas vezes confundida com a religião e a espiritualidade. O presente artigo objetiva analisar a espiritualidade presente na representação da magia no universo Marvel. Foram identificadas três formas principais pelas quais a magia é representada nos quadrinhos da Marvel: (1) como fruto de pacto demoníaco; (2) como manipulação do campo quântico; e (3) como ciência outra. Concluímos que as representações de magia pela Marvel são um exemplo da perpetuação de um ethos nova era, difundido através de meios de comunicação pela sociedade mais ampla.

SPIRITUALITY AND MAGIC IN THE MARVEL COMICS

Magic is a constant in superheroes stories, and is often confused with religion and spirituality. The present article aims to analyze the spirituality that is present in the representation of magic in the Marvel universe. The three main ways in which the spell is represented in Marvel Comics were identified: (1) as a product of a demonic covenant; (2) as a manipulation of the quantum field; and (3) as a form of science. We conclude that Marvel’s representations of magic are an example of the perpetuation of a new age ethos, diffused by mass media through the wider society.
A ESCUTA E O DIÁLOGO COM AS TRADIÇÕES SAGRADAS DO POVO TICUNA: UM TESTEMUNHO DE EVANGELIZAÇÃO NA AMAZÔNIA
Authors: Nef Ulloa Boris Agustín , Patuzzo Izabel
Published: April 2019

Em sintonia com o convite do Papa Francisco à Igreja Ameríndia em buscar novos caminhos de evangelização, este artigo tem como objetivo refletir sobre a contribuição das histórias sagradas dos povos originários da Pan-Amazônia no processo de evangelização dos mesmos, segundo a proposta do Sínodo da Igreja na Pan-Amazônia. As histórias sagradas aqui partilhadas são fruto da escuta de um Povo específico: o Ticuna, na sua grande maioria, católica, presente na Diocese do Alto do Solimões. A missão da Igreja há décadas em seu meio é um testemunho, um sinal desta escuta às muitas comunidades das periferias da Amazônia, fortalecendo seu protagonismo no caminho do discipulado e da confirmação de sua identidade cultural.

LISTENING AND DIALOGUE WITH THE SACRED TRADITIONS OF THE TIKUNA PEOPLE: A WITNESS OF DE EVANGELIZATION IN THE AMAZON

In line with the invitation to the Amerindia’s Church, in finding new ways of evangelization, this article aims to reflect about how much the indigenous people’s cosmogony can contribute to their own evangelization as the Synod of Pan-Amazon Synod proposed. The sacred stories mentioned in this sharing, is a result of hearing a specific People: The Tikuna, since mostly of them became catholic from of Alto Solimões’s Diocese. For decades, the mission’s church among them has been a signal of hearing so many of these communities in the peripheries of Amazonia, willing to strengthen their protagonism in the path of discipleship and the confirmation of their cultural identify.
HERMENÊUTICA BÍBLICA DA PASTORAL DA JUVENTUDE: CENÁRIOS E APROXIMAÇÕES A PARTIR DE ÊXODO 3,1-6.
Authors: Toledo Joilson de Souza
Published: April 2019

Dissertação com tema sobre Juventude e Pastoral da Juventude.

Biblical Hermeneutics of Youth Ministry: Scenery and Approaches from Exodus 3,1-6.