bluuebunny/crossref_metadata_2025 huggingface dataset:
9. Value added tax
Authors: Firth Clare , Seymour Jennifer , Crompton Lucy , Fox Helen , Seabridge Frances , Seymour Jennifer , Smart Elizabeth
Published: July 2021

Value added tax (VAT) is a tax charged on supplies of goods and services made by businesses that have (or should have) registered for VAT. This chapter discusses the circumstances in which VAT is charged; the rates of VAT; when VAT can be reclaimed; accounting for VAT; and doing VAT calculations.
7. Obtaining Identification Evidence
Authors: Hannibal Martin , Mountford Lisa
Published: July 2021

This chapter considers the following: the dangers of eye-witness identification; how identification evidence is obtained by the police during the police investigation; the pre-trial safeguards contained in the identification procedures under Code D of the Police and Criminal Evidence Act 1984 (PACE); the admissibility of eye-witness evidence obtained in breach of Code D; obtaining fingerprints, intimate and non-intimate samples at the police station; DNA evidence and identification evidence given by expert witnesses.
1. Introduction
Authors: Macgregor Lucilla , Peacey Charlotte , Ridsdale Georgina
Published: July 2021

This introductory chapter explains the philosophy of the book and its pedagogical features. It assists in broadening research skills and knowledge. Further, it introduces the Civil Procedure Rules. Finally, it highlights professional conduct considerations and how they are dealt with in this book.
18. Experts and Expert Evidence
Authors: Macgregor Lucilla , Peacey Charlotte , Ridsdale Georgina
Published: July 2021

This chapter focuses on the role of experts in civil actions. It considers when expert support is needed—whether as part of the evidence submitted in the action or as part of the advice sought to prepare the client’s case or perhaps for both situations. It discusses the role that the expert will take in both of the situations identified; when permission of the court is needed to engage and submit expert evidence in the action; the need to provide a cost estimate of using an expert and the costs consequences for the client in engaging expert evidence; the management and suitable direction of steps taken in advising clients and proceeding with an action to meet the court’s overall discretion to control the evidence; and the important matters to consider in engaging an expert and in managing several experts in a case.
2. Important Principles of Land Law
Authors: Richards Mark
Published: July 2021

Land Law is an important foundation for the study of Property Law and Practice (PLP). This chapter summarizes the fundamental principles of land law. It covers estates and interests in land; trusts and co-ownership; easements; freehold covenants; leases; mortgages; and third party rights, overriding interests, and the register and classes of title.
4. Taking Instructions and Other Initial Matters
Authors: Richards Mark
Published: July 2021

This chapter discusses initial activities in the conveyancing process including advising joint buyers on co-ownership; advising buyers to have a survey of the property carried out before exchange of contracts; estate agents; capital gains tax; stamp duty land tax; client care and advice on costs; professional conduct; the Law Society’s National Conveyancing Protocol; and advising on finance.
14. Post-Completion Procedures
Authors: Richards Mark
Published: July 2021

Conveyancing practitioners, whether they are acting for the seller or the buyer, still have much to do once completion has taken place. However, the buyer’s solicitor will have more work to do, as in most transactions acting on behalf of the buyer means after completion dealing with the possible payment of stamp duty land tax and then registration of the title and/or transfer. So far as the seller is concerned, if there is a mortgage, paying off any lender is required, as well as accounting to the client for the net proceeds of sale. This chapter considers all these post-completion procedures.
18. Commercial Conveyancing
Authors: Richards Mark
Published: July 2021

Commercial conveyancing services support the market in and for commercial property. This chapter focuses on several different topics that relate to commercial property and involve specialist knowledge of commercial conveyancing. These include commercial leases; buying and selling commercial freeholds; and commercial property and some elements of revenue law.
6. The partnership agreement
Authors: Slorach J. Scott , Ellis Jason
Published: July 2021

This chapter focuses on provisions that may be included in a partnership agreement. It first considers whether a formal, written agreement is necessary at all. It then discusses the clauses of the partnership agreement and the issues which a prospective new partner might wish to consider before putting his signature to a partnership agreement.
8. Formation of a limited company
Authors: Slorach J. Scott , Ellis Jason
Published: July 2021

This chapter considers the process by which a limited company is formed and the steps required both for and following its formation. It also looks at the related changes which can be made to a company’s main features. The process of registering a company is governed by the Companies Act 2006.
29. Sale of a business to a company
Authors: Slorach J. Scott , Ellis Jason
Published: July 2021

A sole trader or partnership may decide, for a variety of reasons, to incorporate the business. Incorporation will give rise to a number of tax and other problems. This chapter considers these problems and how they can be avoided, or at least mitigated. It shows that the tax rules are the most important consideration in this area, since if they are not appreciated, an unexpected tax bill can cause very serious cash flow problems. They include rules on income tax, capital gains tax, VAT, and stamp duty/stamp duty land tax.
20. Additional Claims under Part 20
Authors: Sime Stuart
Published: July 2021

This chapter discusses the rules for additional claims under Part 20 of the Civil Procedure Rules 1998 (CPR). An additional claim typically will seek to pass any liability established against the defendant to a third party. This is achieved by seeking indemnities, contributions, or related remedies against the third party. A third party may in turn seek to pass on its liability to a fourth party, and so on. Permission to issue an additional claim is not required if the additional claim is issued before or at the same time as the defendant files its defence. An additional claim operates as a separate claim within the original claim.
26. Security for Costs
Authors: Sime Stuart
Published: July 2021

The question of who pays for the costs of a claim is generally not determined until the claim is finally disposed of, whether by consent, interim process, or trial. However, an order for security for costs can be made against a party in the position of a claimant. Once security is given it may be retained, subject to the court’s discretion, pending an appeal. An order for security for costs usually requires the claimant to pay money into court as security for the payment of any costs order that may eventually be made in favour of the defendant, and staying the claim until the security is provided. On the application three issues arise: (a) whether one of the conditions for ordering security for costs is satisfied; (b) if so, whether, having regard to all the circumstances of the case, it would be just to exercise the court’s discretion in favour of making the order; and (c) if so, how much security should be provided. This chapter considers each of these three issues. It begins by looking at the procedure for making the application and the capacity of the respondent to the application.
35. Experts
Authors: Sime Stuart
Published: July 2021

This chapter discusses the principles governing the use of expert evidence in civil claims. It covers the admissibility of expert evidence; control of evidence; choice of expert; privileged nature of experts’ reports; disclosure of experts’ reports; written questions to experts; examinations by experts; experts’ immunity from suit; and use of experts’ reports after trial.
38. Listing and Pre-Trial Reviews
Authors: Sime Stuart
Published: July 2021

Claims that are not compromised and which do not end through striking out or summary or default judgment, have to be determined by the court at trial. Listing is the process whereby the court gives a date for the trial. This chapter discusses listing for trial; pre-trial reviews; listing in the Royal Courts of Justice; and adjournments.
44. Search Orders
Authors: Sime Stuart
Published: July 2021

This chapter discusses the rules for search orders. A search order is a bundle of interim orders which require the respondent to admit another party to premises for the purpose of preserving evidence which might otherwise be destroyed or concealed by the respondent. Search orders are principally, but not exclusively, used in intellectual property claims against defendants who are likely to destroy incriminating evidence rather than disclose it voluntarily under standard disclosure.
Loss ofZic3impairs planar cell polarity leading to abnormal left–right signaling, heart defects and neural tube defects
Authors: Bellchambers Helen M , Ware Stephanie M
Published: July 2021

Loss of function of ZIC3 causes heterotaxy (OMIM #306955), a disorder characterized by organ laterality defects including complex heart defects. Studies using Zic3 mutant mice have demonstrated that loss of Zic3 causes heterotaxy due to defects in establishment of left–right (LR) signaling, but the mechanistic basis for these defects remains unknown. Here, we demonstrate Zic3 null mice undergo cilia positioning defects at the embryonic node consistent with impaired planar cell polarity (PCP). Cell-based assays demonstrate that ZIC3 must enter the nucleus to regulate PCP and identify multiple critical ZIC3 domains required for regulation of PCP signaling. Furthermore, we show that Zic3 displays a genetic interaction with the PCP membrane protein Vangl2 and the PCP effector genes Rac1 and Daam1 resulting in increased frequency and severity of neural tube and heart defects. Gene and protein expression analyses indicate that Zic3 null embryos display disrupted expression of PCP components and reduced phosphorylation of the core PCP protein DVL2 at the time of LR axis determination. These results demonstrate that ZIC3 interacts with PCP signaling during early development, identifying a novel role for this transcription factor, and adding additional evidence about the importance of PCP function for normal LR patterning and subsequent heart development.
WNT2 activation through proximal germline deletion predisposes to small intestinal neuroendocrine tumors and intestinal adenocarcinomas
Authors: Aavikko Mervi , Kaasinen Eevi , Andersson Noora , Pentinmikko Nalle , Sulo Päivi , Donner Iikki , Pihlajamaa Päivi , Kuosmanen Anna , Bramante Simona , Katainen Riku , Sipilä Lauri J , Martin Samantha , Arola Johanna , Carpén Olli , Heiskanen Ilkka , Mecklin Jukka-Pekka , Taipale Jussi , Ristimäki Ari , Lehti Kaisa , Gucciardo Erika , Katajisto Pekka , Schalin-Jäntti Camilla , Vahteristo Pia , Aaltonen Lauri A
Published: July 2021

Many hereditary cancer syndromes are associated with an increased risk of small and large intestinal adenocarcinomas. However, conditions bearing a high risk to both adenocarcinomas and neuroendocrine tumors are yet to be described.

We studied a family with 16 individuals in four generations affected by a wide spectrum of intestinal tumors, including hyperplastic polyps, adenomas, small intestinal neuroendocrine tumors, and colorectal and small intestinal adenocarcinomas.

To assess the genetic susceptibility and understand the novel phenotype, we utilized multiple molecular methods, including whole genome sequencing, RNA sequencing, single cell sequencing, RNA in situ hybridization and organoid culture.

We detected a heterozygous deletion at the cystic fibrosis locus (7q31.2) perfectly segregating with the intestinal tumor predisposition in the family. The deletion removes a topologically associating domain border between CFTR and WNT2, aberrantly activating WNT2 in the intestinal epithelium. These consequences suggest that the deletion predisposes to small intestinal neuroendocrine tumors and small and large intestinal adenocarcinomas, and reveals the broad tumorigenic effects of aberrant WNT activation in the human intestine.
Complex Temporal Biology: Towards a Unified Multi-Scale Approach to Predict the Flow of Information
Authors: Alicea Bradly , Yuan Chongli
Published: July 2021

Synopsis

Two hallmarks of biological processes are complexity and time. While complexity can have many meanings, in this paper we propose an explicit link to the flow of time and how it is experienced by the organism. While the flow of time is rooted in constraints of fundamental physics, understanding the operation of biological systems in terms of processual flow and tempo is more elusive. Fortunately, the convergence of new computational and methodological perspectives will provide a means to transform complicated, nonlinear paths between related phenomena at different time scales into dynamic four-dimensional perspectives. According to the complex temporal biology approach, information flow between time scales of multiple lengths is a transformational process that acts to regulate life's complexity. Interactions between temporal intervals of differing magnitude and otherwise loosely-related mechanisms can be understood as inter-timescale information flow. We further propose that informational flow between time scales is the glue that binds the multiple vertical layers of biocomplexity, as well as yielding surprising outcomes ranging from complex behaviors to the persistence of lineages. Building a foundation of rules based on common interactions between orders of time and common experiential contexts would help to reintegrate biology. Emerging methodologies such as state-of-the-art imaging, visualization techniques, and computational data analysis can help us uncover these interactions. In conclusion, we propose educational and community-level changes that would better enable our vision.
Does Social Science Inform Foreign Policy? Evidence from a Survey of US National Security, Trade, and Development Officials
Authors: Avey Paul C , Desch Michael C , Parajon Eric , Peterson Susan , Powers Ryan , Tierney Michael J
Published: July 2021

Scholars continue to debate the relationship of academic international relations to policy. One of the most straightforward ways to discern whether policymakers find IR scholarship relevant to their work is to ask them. We analyzed an elite survey of US policy practitioners to better understand the conditions under which practitioners use academic knowledge in their work. We surveyed officials across three different policy areas: international development, national security, and trade. We also employed multiple survey experiments in an effort to causally identify the impact of academic consensus on the views of policy officials and to estimate the relative utility of different kinds of research outputs. We found that policymakers frequently engage with academic ideas, find an array of research outputs and approaches useful, and that scholarly findings can shift their views. Key obstacles to using academic knowledge include practitioners' lack of time as well as academic work being too abstract and not timely, but not that it is overly quantitative. Additionally, we documented important differences between national security officials and their counterparts who work in the areas of development and trade. We suggest that this variation is rooted in the nature of the different policy areas.
Between Deference and Defiance: Hierarchical Status Roles and International Conflict
Authors: Wolf Reinhard
Published: July 2021

According to recent international relations research, an actor's status ultimately depends on commonly accepted ratings of that actor's valued attributes (e.g., wealth, competence, culture, or coercive capabilities). This manuscript argues that asymmetric reciprocal roles (leaders versus followers, patrons versus clients, teachers versus students, etc.) constitute another, even more fundamental, kind of stratification that can provoke far more acrimonious status conflicts. Such role-based hierarchies remain stable as long as subordinate actors deem their superiors entitled to deferential treatment. Disputes over asymmetrical roles arise when subaltern actors begin to question the right of dominant actors to command, or when actors fear that co-equal parties are trying to establish their social dominance through a series of faits accomplis. In such circumstances, defiance is the status tactic of choice because it directly undercuts disconcerting patterns of deference. By systematically theorizing defiance in status hierarchies, the paper provides an overdue addition to the literature on the breakdown of cooperation and the dissolution of order. It first sketches a theory that lays out the motives and forms of defiant behavior in international status disputes and then illustrates its value in explaining Russian and Greek resistance to domineering Western “partners.”
International Cooperation and Natural Disasters: Evidence from Trade Agreements
Authors: Conevska Aleksandra
Published: July 2021

Environmental shocks in the form of natural disasters are well known for their impact on domestic economies. Less known, however, is their impact on the global economy. The scant existing literature suggests that macro-economic impacts manifest in observed empirical decreases in international trade. The literature, however, does not examine whether the impact of natural disasters on trade varies for trading partners with differing levels of market integration. This paper examines if preferential liberalization serves to protect or buffer against the negative economic consequences of natural disasters. I show that deep preferential liberalization can not only protect countries against the negative macro-economic impact of natural disasters but can actually allow countries to increase exports during natural disaster events that otherwise induce trade decline. These findings suggest that by allowing countries to expand the quantity and the range of exports, preferential trade agreements lead to enhanced resilience against exogenous shocks.
GraphSynergy: a network-inspired deep learning model for anticancer drug combination prediction
Authors: Yang Jiannan , Xu Zhongzhi , Wu William Ka Kei , Chu Qian , Zhang Qingpeng
Published: July 2021

Objective

To develop an end-to-end deep learning framework based on a protein–protein interaction (PPI) network to make synergistic anticancer drug combination predictions.

Materials and Methods

We propose a deep learning framework named Graph Convolutional Network for Drug Synergy (GraphSynergy). GraphSynergy adapts a spatial-based Graph Convolutional Network component to encode the high-order topological relationships in the PPI network of protein modules targeted by a pair of drugs, as well as the protein modules associated with a specific cancer cell line. The pharmacological effects of drug combinations are explicitly evaluated by their therapy and toxicity scores. An attention component is also introduced in GraphSynergy, which aims to capture the pivotal proteins that play a part in both PPI network and biomolecular interactions between drug combinations and cancer cell lines.

Results

GraphSynergy outperforms the classic and state-of-the-art models in predicting synergistic drug combinations on the 2 latest drug combination datasets. Specifically, GraphSynergy achieves accuracy values of 0.7553 (11.94% improvement compared to DeepSynergy, the latest published drug combination prediction algorithm) and 0.7557 (10.95% improvement compared to DeepSynergy) on DrugCombDB and Oncology-Screen datasets, respectively. Furthermore, the proteins allocated with high contribution weights during the training of GraphSynergy are proved to play a role in view of molecular functions and biological processes, such as transcription and transcription regulation.

Conclusion

The introduction of topological relations between drug combination and cell line within the PPI network can significantly improve the capability of synergistic drug combination identification.
Amplification and Characterization of DDT Metabolizing Delta Class GST in Sand Fly,Phlebotomus argentipes(Diptera: Psychodidae) From Bihar, India
Authors: Hassan Faizan , Singh Krishn Pratap , Shivam Pushkar , Ali Vahab , Dinesh Diwakar Singh
Published: July 2021

Phlebotomus argentipes is an established vector for Visceral leishmaniasis prevalent in the Indian subcontinent. Insect Glutathione S-transferases (GST) enzyme plays a pivotal role in the metabolism of xenobiotics and chemical insecticides. We report herein the identification and characterization of a delta class GST from the sandfly, P. argentipes. The resulting clone (rParg-GSTδ) is successfully sequenced, which revealed 76.43% and 66.32% gene identity with GST from Phlebotomus papatasi (Scopoli; Diptera: Psychodidae) and Lutzomiya longipalpis (Lutz and Neiva; Diptera: Psychodidae), respectively. The identified rParg-GST amino acid Blast results revealed 82.6% homology to delta class GST of Phlebotomus papatasi and more than 50% homology to Lepidoptera which comprises butterflies and moths. The Phylogenetic analysis of Parg-GST with different classes of Insect GSTs further supported its classification as delta class. A functional recombinant Parg-GSTδ protein (rParg-GSTδ) was expressed in Escherichia coli (Migula; Enterobacterales: Enterobacteriaceae) cells in a soluble form, purified to homogeneity and found to be active against a substrate 1-chloro-2,4-dintrobenzene (CDNB) and lipid peroxidation by-product 4-Hydrxynonenal (4-HNE). Interestingly, rParg-GSTδ demonstrates high dehydrochlorination activity against dichlorodiphenyltrichloroethane (DDT) i.e., 16.27 nM/µg in high performance liquid chromatography (HPLC) assay. These results provide evidence of direct DDT metabolism property exhibited by P. argentipes GST and set the foundation to decipher the metabolic resistance mechanism in P. argentipes against insecticides.
Cancer Misinformation and Harmful Information on Facebook and Other Social Media: A Brief Report
Authors: Johnson Skyler B , Parsons Matthew , Dorff Tanya , Moran Meena S , Ward John H , Cohen Stacey A , Akerley Wallace , Bauman Jessica , Hubbard Joleen , Spratt Daniel E , Bylund Carma L , Swire-Thompson Briony , Onega Tracy , Scherer Laura D , Tward Jonathan , Fagerlin Angela
Published: July 2021

There are few data on the quality of cancer treatment information available on social media. Here, we quantify the accuracy of cancer treatment information on social media and its potential for harm. Two cancer experts reviewed 50 of the most popular social media articles on each of the 4 most common cancers. The proportion of misinformation and potential for harm were reported for all 200 articles and their association with the number of social media engagements using a 2-sample Wilcoxon rank-sum test. All statistical tests were 2-sided. Of 200 total articles, 32.5% (n = 65) contained misinformation and 30.5% (n = 61) contained harmful information. Among articles containing misinformation, 76.9% (50 of 65) contained harmful information. The median number of engagements for articles with misinformation was greater than factual articles (median [interquartile range] = 2300 [1200-4700] vs 1600 [819-4700], P = .05). The median number of engagements for articles with harmful information was statistically significantly greater than safe articles (median [interquartile range] = 2300 [1400-4700] vs 1500 [810-4700], P = .007).
Urosymphyseal fistulas in women: identification and characterization of a previously undescribed phenomenon
Authors: Anele Uzoma A , Wood Hadley M , Angermeier Kenneth W
Published: July 2021

Urosymphyseal fistula (USF) is a very uncommon but catastrophic condition which typically occurs in the setting of previous radiation treatment for prostate cancer. As a result, USF has only been described in male populations. For the first time, we characterize this phenomenon in a series consisting of four women managed at our quaternary institution. We found that most patients presented with pubic pain and all were diagnosed with USF on CT or MRI. Imaging commonly demonstrated features suggesting osteomyelitis which was confirmed on histology. Patients experienced significant decreases in peri-operative pain scores following extirpative surgery with urinary diversion, bone debridement/resection and tissue interposition. This case series highlights the rarity of USF in women in order to help promote increased recognition and timely management.
Adjunctive efficacy of intra-arterial cone-beam computed tomography angiography in the endovascular treatment of vertebra–venous fistula
Authors: Lu Yu-Chun , Wen Chung-Yu , Yang Shun-Tai , Lu Yueh-Hsun , Su I-Chang
Published: July 2021

Vertebro–venous fistula (VVF) refers to an abnormal arteriovenous shunt connecting the extracranial vertebral artery and the paraspinal venous structures. Coil embolization is the mainstay treatment of choice for VVF, and accurate definition of the endovascular target is mandatory. Traditionally, catheter-based angiograms are used for treatment planning, but those images lack bony information to delineate the precise relationship of the drainage veins to the spinal structure. Herein, we presented two VVF cases and demonstrated how we used intra-arterial cone-beam computed tomography angiography (IA-CBCTA) to determine the safe embolization zone for dense coil packing. We propose that IA-CBCTA is a useful adjunct in the endovascular planning of VVF by offering an image consisting of bony and vascular information.
Nonsense-mediated mRNA decay modulates Arabidopsis flowering time via the SET DOMAIN GROUP 40–FLOWERING LOCUS C module
Authors: Nasim Zeeshan , Fahim Muhammad , Hwang Hocheol , Susila Hendry , Jin Suhyun , Youn Geummin , Ahn Ji Hoon
Published: July 2021

The nonsense-mediated mRNA decay (NMD) surveillance system clears aberrant mRNAs from the cell, thus preventing the accumulation of truncated proteins. Although loss of the core NMD proteins UP-FRAMESHIFT1 (UPF1) and UPF3 leads to late flowering in Arabidopsis, the underlying mechanism remains elusive. Here, we showed that mutations in UPF1 and UPF3 cause temperature- and photoperiod-independent late flowering. Expression analyses revealed high FLOWERING LOCUS C (FLC) mRNA levels in upf mutants; in agreement with this, the flc mutation strongly suppressed the late flowering of upf mutants. Vernalization accelerated flowering of upf mutants in a temperature-independent manner. FLC transcript levels rose in wild-type plants upon NMD inhibition. In upf mutants, we observed increased enrichment of H3K4me3 and reduced enrichment of H3K27me3 in FLC chromatin. Transcriptome analyses showed that SET DOMAIN GROUP 40 (SDG40) mRNA levels increased in upf mutants, and the SDG40 transcript underwent NMD-coupled alternative splicing, suggesting that SDG40 affects flowering time in upf mutants. Furthermore, NMD directly regulated SDG40 transcript stability. The sdg40 mutants showed decreased H3K4me3 and increased H3K27me3 levels in FLC chromatin, flowered early, and rescued the late flowering of upf mutants. Taken together, these results suggest that NMD epigenetically regulates FLC through SDG40 to modulate flowering time in Arabidopsis.
Spectroscopic frequency and mode identification of γ Doradus stars HD 109799 and HD 103257
Authors: Shutt T R , Brunsden E , Pollard K R
Published: July 2021

Following frequency and mode identification of two candidate γ Doradus stars, HD 103257 and HD 109799, both can be categorized as bona-fide members of the class. Over 250 high-resolution spectra of the two stars were collected at University of Canterbury Mount John Observatory (UCMJO) using the High Efficiency and Resolution Canterbury University Large Echelle Spectrograph (HERCULES) spectrograph. The spectra were cross-correlated with a synthetic δ-function template to produce line-profiles and further augmented with high-quality photometry from the Transiting Exoplanet Survey Satellite (TESS) mission, the Wide Angle Search for Planets (WASP) archive, and HIPPARCOS catalogue for frequency and mode analysis. Frequency analysis was carried out using FAMIAS and SigSpec. Two pulsation frequencies were identified in the spectra for HD 103257: 1.22496 ± 0.00001 and 1.14569 ± 0.00002 d−1, explaining 58.9 ${{\ \rm per\ cent}}$ of the variation across the line profiles. Both frequencies were characterized with best-fitting modes of (ℓ, m) = (1, 1). Two pulsation frequencies were identified in the spectra for HD 109799: 1.48679 ± 0.00002 and 1.25213 ± 0.00002 d−1, explaining 32.6 ${{\ \rm per\ cent}}$ of the variation across the line profiles. Both frequencies also yielded individual mode fits of modes (ℓ, m) = (1, 1). The excellent quality photometry from TESS observations has proven complementary to the work herein, and will provide a meaningful opportunity for deeper analysis of additional stars in the HERCULES catalogue. This will be a key component in the continued development of models relating to the processes within γ Doradus stars.
Quantitative comparison of opacities calculated using the R-matrix and distorted-wave methods: Fe xvii
Authors: Delahaye F , Ballance C P , Smyth R T , Badnell N R
Published: July 2021

We present here a detailed calculation of opacities for Fe xvii at the physical conditions corresponding to the base of the Solar convection zone. Many ingredients are involved in the calculation of opacities. We review the impact of each ingredient on the final monochromatic and mean opacities (Rosseland and Planck). The necessary atomic data were calculated with the R-matrix and the distorted-wave (DW) methods. We study the effect of broadening, of resolution, of the extent of configuration sets and of configuration interaction to understand the differences between several theoretical predictions as well as the existing large disagreement with measurements. New Dirac R-matrix calculations including all configurations up to the n = 4, 5, and 6 complexes have been performed as well as corresponding Breit–Pauli DW calculations. The DW calculations have been extended to include autoionizing initial levels. A quantitative contrast is made between comparable DW and R-matrix models. We have reached self-convergence with n = 6 R-matrix and DW calculations. Populations in autoionizing initial levels contribute significantly to the opacities and should not be neglected. The R-matrix and DW results are consistent under the similar treatment of resonance broadening. The comparison with the experiment shows a persistent difference in the continuum while the filling of the windows shows some improvement. This study defines our path to the next generation of opacities and opacity tables for stellar modelling.
Degeneracies between baryons and dark matter: the challenge of constraining the nature of dark matter with JWST
Authors: Khimey Diana , Bose Sownak , Tacchella Sandro
Published: July 2021

The James Webb Space Telescope (JWST) will revolutionize our understanding of early galaxy formation, and could potentially set stringent constraints on the nature of dark matter. We use a semi-empirical model of galaxy formation to investigate the extent to which uncertainties in the implementation of baryonic physics may be degenerate with the predictions of two different models of dark matter – cold dark matter (CDM) and a 7 keV sterile neutrino, which behaves as warm dark matter (WDM). Our models are calibrated to the observed UV luminosity function at z = 4 using two separate dust attenuation prescriptions, which manifest as high and low star formation efficiency in low-mass haloes. These efficiencies capture the net effect of processes that regulate star formation. We find that while at fixed star formation efficiency, ε, there are marked differences in the abundance of faint galaxies in the two dark matter models at high-z; these differences are mimicked easily by varying ε in the same dark matter model. We find that a high ε WDM and a low ε CDM model – which provide equally good fits to the z = 4 UV luminosity function – exhibit nearly identical evolution in the cosmic stellar mass and star formation rate densities. We show that differences in the star formation rate at fixed stellar mass are larger for variations in ε in a given dark matter model than they are between dark matter models; however, the scatter in star formation rates is larger between the two models than they are when varying ε. Our results suggest that JWST will likely be more informative in constraining baryonic processes operating in high-z galaxies than it will be in constraining the nature of dark matter.
On dust evolution in planet-forming discs in binary systems – II. Comparison with Taurus and ρ Ophiuchus (sub-)millimetre observations: discs in binaries have small dust sizes
Authors: Zagaria Francesco , Rosotti Giovanni P , Lodato Giuseppe
Published: July 2021

The recently discovered exoplanets in binary or higher order multiple stellar systems sparked a new interest in the study of protoplanetary discs in stellar aggregations. Here, we focus on disc solids, as they make up the reservoir out of which exoplanets are assembled and dominate (sub-)millimetre disc observations. These observations suggest that discs in binary systems are fainter and smaller than in isolated systems. In addition, disc dust sizes are consistent with tidal truncation only if they orbit very eccentric binaries. In a previous study, we showed that the presence of a stellar companion hastens the radial migration of solids, shortening disc lifetime, and challenging planet formation. In this paper, we confront our theoretical and numerical results with observations: Disc dust fluxes and sizes from our models are computed at ALMA wavelengths and compared with Taurus and ρ Ophiuchus data. A general agreement between theory and observations is found. In particular, we show that the dust disc sizes are generally smaller than the binary truncation radius due to the combined effect of grain growth and radial drift: Therefore, small disc sizes do not require implausibly high eccentricities to be explained. Furthermore, the observed binary discs are compatible within 1σ with a quadratic flux–radius correlation similar to that found for single-star discs and show a close match with the models. However, the observational sample of resolved binary discs is still small and additional data are required to draw more robust conclusions on the flux–radius correlation and how it depends on the binary properties.
The impact of mixing treatments on cloud modelling in 3D simulations of hot Jupiters
Authors: Christie D A , Mayne N J , Lines S , Parmentier V , Manners J , Boutle I , Drummond B , Mikal-Evans T , Sing D K , Kohary K
Published: July 2021

We present results of 3D hydrodynamical simulations of HD209458b including a coupled, radiatively active cloud model (eddysed). We investigate the role of the mixing by replacing the default convective treatment used in previous works with a more physically relevant mixing treatment (Kzz) based on global circulation. We find that uncertainty in the efficiency of sedimentation through the sedimentation factor fsed plays a larger role in shaping cloud thickness and its radiative feedback on the local gas temperatures – e.g. hotspot shift and day-to-night side temperature gradient – than the switch in mixing treatment. We demonstrate using our new mixing treatments that simulations with cloud scales that are a fraction of the pressure scale height improve agreement with the observed transmission spectra, the emission spectra, and the Spitzer 4.5 µm phase curve, although our models are still unable to reproduce the optical and ultraviolet transmission spectra. We also find that the inclusion of cloud increases the transit asymmetry in the optical between the east and west limbs, although the difference remains small ($\lesssim 1{{\ \rm per\ cent}}$).
Binary central stars of planetary nebulae identified with Kepler/K2
Authors: Jacoby George H , Hillwig Todd C , Jones David , Martin Kayla , De Marco Orsola , Kronberger Matthias , Hurowitz Jonathan L , Crocker Alison F , Dey Josh
Published: July 2021

We present the identification of 34 likely binary central stars (CSs) of planetary nebulae (PNe) from Kepler/K2 data, seven of which show eclipses. Of these, 29 are new discoveries. Two additional CSs with more complicated variability are also presented. We examined the light curves of all ‘possible’, ‘likely’, and ‘true’ PNe in every Kepler/K2 campaign (0 through 19) to identify CS variability that may indicate a binary CS. For Campaigns 0, 2, 7, 15, and 16, we find 6 likely or confirmed variables among 21 PNe. Our primary effort, though, was focused on Campaign 11 which targeted a Galactic bulge field containing approximately 183 PNe, in which we identified 30 candidate variable CSs. The periods of these variables range from 2.3 h to 30 d, and based on our analysis, most are likely to be close binary star systems. We present periods and preliminary classifications (eclipsing, double degenerate, or irradiated systems) for the likely binaries based on light-curve shape. From our total sample of 204 target PNe, with a correction for incompleteness due to magnitude limits, we calculate a binary fraction of PN central stars to be 20.7 per cent for all the observed PNe, or 23.5 per cent if we limit our sample only to ‘true’ PNe. However, these fractions are almost certainly lower limits due to the large angular size of the Kepler pixels, which leads to reduced sensitivity in detecting variability, primarily as a result of dilution and noise from the nebula and neighbouring stars. We discuss the binary population of CSs based on these results as part of the total known sample of close binary CSs.
A hard X-ray view of luminous and ultra-luminous infrared galaxies in GOALS – I. AGN obscuration along the merger sequence
Authors: Ricci C , Privon G C , Pfeifle R W , Armus L , Iwasawa K , Torres-Albà N , Satyapal S , Bauer F E , Treister E , Ho L C , Aalto S , Arévalo P , Barcos-Muñoz L , Charmandaris V , Diaz-Santos T , Evans A S , Gao T , Inami H , Koss M J , Lansbury G , Linden S T , Medling A , Sanders D B , Song Y , Stern D , U V , Ueda Y , Yamada S
Published: July 2021

The merger of two or more galaxies can enhance the inflow of material from galactic scales into the close environments of active galactic nuclei (AGNs), obscuring and feeding the supermassive black hole (SMBH). Both recent simulations and observations of AGN in mergers have confirmed that mergers are related to strong nuclear obscuration. However, it is still unclear how AGN obscuration evolves in the last phases of the merger process. We study a sample of 60 luminous and ultra-luminous IR galaxies (U/LIRGs) from the GOALS sample observed by NuSTAR. We find that the fraction of AGNs that are Compton thick (CT; $N_{\rm H}\ge 10^{24}\rm \, cm^{-2}$) peaks at $74_{-19}^{+14}{{\ \rm per\ cent}}$ at a late merger stage, prior to coalescence, when the nuclei have projected separations (dsep) of 0.4–6 kpc. A similar peak is also observed in the median NH [$(1.6\pm 0.5)\times 10^{24}\rm \, cm^{-2}$]. The vast majority ($85^{+7}_{-9}{{\ \rm per\ cent}}$) of the AGNs in the final merger stages (dsep ≲ 10 kpc) are heavily obscured ($N_{\rm H}\ge 10^{23}\rm \, cm^{-2}$), and the median NH of the accreting SMBHs in our sample is systematically higher than that of local hard X-ray-selected AGN, regardless of the merger stage. This implies that these objects have very obscured nuclear environments, with the $N_{\rm H}\ge 10^{23}\rm \, cm^{-2}$ gas almost completely covering the AGN in late mergers. CT AGNs tend to have systematically higher absorption-corrected X-ray luminosities than less obscured sources. This could either be due to an evolutionary effect, with more obscured sources accreting more rapidly because they have more gas available in their surroundings, or to a selection bias. The latter scenario would imply that we are still missing a large fraction of heavily obscured, lower luminosity ($L_{2-10}\lesssim 10^{43}\rm \, erg\, s^{-1}$) AGNs in U/LIRGs.
On the role of Type Ia supernovae in the second-generation star formation in globular clusters
Authors: Lacchin E , Calura F , Vesperini E
Published: July 2021

By means of 3D hydrodynamic simulations, we study how Type Ia supernovae (SNe) explosions affect the star formation history and the chemical properties of second-generation (SG) stars in globular clusters (GC). SG stars are assumed to form once first generation asymptotic giant branch (AGB) stars start releasing their ejecta; during this phase, external gas is accreted by the system and SNe Ia begin exploding, carving hot and tenuous bubbles. Given the large uncertainty on SNe Ia explosion times, we test two different values for the ‘delay time’. We run two different models for the external gas density: in the low-density scenario with short delay time, the explosions start at the beginning of the SG star formation, halting it in its earliest phases. The external gas hardly penetrates the system, therefore most SG stars present extreme helium abundances (Y > 0.33). The low-density model with delayed SN explosions has a more extended SG star formation epoch and includes SG stars with modest helium enrichment. On the contrary, the high-density model is weakly affected by SN explosions, with a final SG mass similar to the one obtained without SNe Ia. Most of the stars form from a mix of AGB ejecta and pristine gas and have a modest helium enrichment. We show that gas from SNe Ia may produce an iron spread of ∼0.14 dex, consistent with the spread found in about $20{{\ \rm per\ cent}}$ of Galactic GCs, suggesting that SNe Ia might have played a key role in the formation of this sub-sample of GCs.
A Canker Barking at the Wrong Knee: Thyronectria austroamericana Septic Arthritis
Authors: Rutjanawech Sasinuch , Mejia-Chew Carlos , Ayres Chapelle , Spec Andrej
Published: July 2021

The mold Thyronectria austroamericana is a plant pathogen that causes canker in honey locust trees. We describe the first case of this mold causing septic arthritis in humans.
Predictors of Self-Reported Neglect-like Symptoms and Involuntary Movements in Complex Regional Pain Syndrome Compared to Other Chronic Limb Pain Conditions
Authors: Ten Brink Antonia F , Bultitude Janet H
Published: July 2021

Objective

In addition to pain, people with complex regional pain syndrome (CRPS) often report inattention to and disengagement from their affected limb (i.e., “neglect-like symptoms”). Understanding how these symptoms relate to other characteristics of CRPS, and chronic pain generally, could provide insights for preventing and treating CRPS.

Methods

We administered an online survey to people who received a diagnosis of CRPS (n = 335) and other chronic limb pain (n = 407). Neglect-like symptoms were assessed using the Neurobehavioral questionnaire.

Results

A principal component analysis identified two components: motor and cognitive neglect-like symptoms, and involuntary movements. Internal consistency of the components was acceptable. We conducted regression analyses with these as outcomes. Having CRPS, a painful lower limb, higher pain intensity, and somatic symptoms were associated with more motor and cognitive neglect-like symptoms. Having CRPS, higher pain intensity, depression, and somatic symptoms were associated with more involuntary movements. Age, gender, anxiety, disease duration, hours of pain per day, affected side, whether the limb was the most painful body part, and number of pain-related medical diagnoses were no predictors. Finally, motor and cognitive neglect-like symptoms were related to tremor; and involuntary movements to changes in skin color, swelling, sweating, toenails, weakness, and tremor.

Conclusions

This study confirms the specificity of inattention to and disengagement from the affected limb in CRPS, independent of other factors. Furthermore, two components of the Neurobehavioral questionnaire were disentangled: motor and cognitive neglect-like symptoms, and involuntary movements. Results could potentially help clinicians to better assess neglect-like symptoms in chronic pain .
In vivoinducing collagen regeneration of biodegradable polymer microspheres
Authors: Zhang Yixin , Liang Hanwen , Luo Qian , Chen Jianlin , Zhao Nan , Gao Wenxia , Pu Yuji , He Bin , Xie Jing
Published: July 2021

Biodegradable polymer particles have been used as dermal fillers for pre-clinical and clinical trials. The impact of material properties of polymers is very important to develop products for aesthetic medicine such as dermal fillers. Herein, eight biodegradable polymers with different molecular weights, chemical compositions or hydrophilic-hydrophobic properties were prepared and characterized for systematical study for aesthetic medicine applications. Polymer microspheres with 20–100 μm were prepared. The in vitro degradation study showed that poly (L-lactic-co-glycolic acid) 75/25 microspheres degraded the fastest, whereas poly (L-lactic acid) (PLLA) microspheres with intrinsic viscosity of 6.89 ([η] = 6.89) with the highest molecular weight showed the slowest degradation rate. After these microspheres were fabricated dermal fillers according to the formula of Sculptra®, they were injected subcutaneously into the back skin of rabbits. In vivo results demonstrated that the degradation rate of microspheres strongly correlated with the foreign body reaction and collagen regeneration was induced by microspheres. The microspheres with faster degradation rate induced inflammatory response and the collagen regeneration maintained in shorter time. PLLA ([η] = 3.80) microsphere with a moderate molecular weight and degradation rate could strongly regenerate Type I and III collagen to maintain a long-term aesthetic medicine effect. These properties of size, morphology and degradation behavior would influence the foreign body reaction and collagen regeneration.
“Please Don’t Take This”: Rural Gentrification, Symbolic Capital, and Housing Insecurity
Authors: Sherman Jennifer
Published: July 2021

Based on 84 in-depth interviews and ten months of ethnographic fieldwork, this paper examines the impacts of gentrification and housing shortages in a rural Western U.S. community. In-migration by wealthy outsiders to the high-amenity community has driven up housing costs, privileging newcomers over longtime locals. The paper examines the impacts of social inequality on the community’s most vulnerable residents, exploring the ways in which housing insecurity is reproduced and how formal and informal infrastructures fail to provide adequate housing options for low-income residents. While income is a significant factor in determining an individual or family’s ability to access stable and affordable housing, symbolic resources, including social and moral capital are also found to play significant roles. The paper describes the mechanisms by which these resources come into play, illustrating how a lack of financial, social, and moral capital disadvantages residents in their struggles to procure housing. It finds that in a rural context where in-migration leads to high inequality, socially marginalized rural residents face a distinctive set of challenges and disadvantages that magnify housing instability and deepen exclusion and precariousness.