bluuebunny/crossref_metadata_2025 huggingface dataset:
VIRTUAL DESIGN OF NOVEL OF ORALLY BIOAVAILABLE PIPERAZINE INHIBITORS OF ENOYL-ACYL CARRIER PROTEIN REDUCTASE OF MYCOBACTERIUM TUBERCULOSIS WITH FAVORABLE PHARMACOKINETIC PROFILES
Authors: Kouman Koffi Charles , Kouassi Afﬁba Florance , Fagnidi Yves Kily Hervé , Fofana Issouf , Allangba Koffi N’Guessan Placide Gabin , Guego Mélalie Kéïtaépouse , Megnassan Eugene
Published: November 2024

Background: During the previous decade, Anti-tuberculosis therapies were confronted with drug-resistant strains. We report here virtual design and evaluation of novel piperazine (PPZ) as inhibitors of InhA-Mt endowed with favorable predicted pharmacokinetic profiles.
Method: Three-dimensional (3D) models of InhA-PPZx complexes were prepared by in situ modiﬁcations of the crystal structure of InhA-PPZ1 (Protein Data Bank (PDB) entry code: 1P44), the reference compound of a training set of 12 PPZs with known experimental inhibitory potencies (IC50exp). First, in the search for active conformation of the PPZ 1-12, we built a gas phase quantitative structure-activity relationships (QSAR) model, linearly correlating the computed enthalpy of the InhA-PPZ complex formation and the pIC50exp. Finally, the VCL filtered by Lipinski’s rule-of-five was screened by the PH4 model and the potencies of the new PPZ analogs obtained were evaluated with the initial QSAR and their pharmacokinetic profile was evaluated.
Results: The VCL of 310,500 PPZs s was filtered down to 19,044 analogs by the Lipinski’s rule. The five-point PH4 screening retained 50 new potent PPZs with predicted inhibitory potencies IC50pre up to 100-times better than that of PPZ1 (IC50exp=160 nM). Predicted pharmacokinetic profile of the new analogs showed enhanced cell membrane permeability, side effect and high human oral absorption compared to current anti-tuberculosis candidates
Conclusions: Combining molecular modeling and PH4 in virtual screening of the VL resulted in the proposed novel potent antituberculotic agent candidates with favorable pharmacokinetic proﬁles.
            
Peer Review History:
Received 21 July 2024;   Reviewed 13 September 2024; Accepted 20 October; Available online 15 November 2024
Academic Editor: Dr. Asia Selman Abdullah, Pharmacy institute, University of Basrah, Iraq, asia_abdullah65@yahoo.com
Average Peer review marks at initial stage: 6.0/10
Average Peer review marks at publication stage: 7.5/10
Reviewers:
Antonio José de Jesus Evangelista, Federal University of Ceará, UFC, Brazil, tony_biomed@hotmail.com
Asmaa Ahmed Mohamed Ahmed Khalifa, Pharos University, Alexandria, Egypt, asmaa.khalifa@pua.edu.eg
SEQUÊNCIA DE ENSINO INVESTIGATIVO SOBRE EFEITOS DA LUZ NOS MATERIAIS: PRODUÇÃO E VALIDAÇÃO
Authors: Angelo Thais da Silva , Oliveira Alana Priscila Lima de , Fireman Elton Casado
Published: November 2024

Este trabalho busca discutir a temática do efeito da luz nos materiais para 3º ano do Ensino Fundamental por meio do desenvolvimento e validação de uma Sequência de Ensino Investigativo - SEI, abordando os conteúdos do efeito da luz nos materiais, uma vez que a Base Nacional Comum Curricular apresenta esse tema como um dos objetos de conhecimento da unidade temática Matéria e Energia do 3º ano do EF. A presente pesquisa apresenta caráter qualitativo e se caracteriza por ser empírica, subjetiva e possibilitar ao pesquisador interpretar a fala dos entrevistados. Como objetivo de pesquisa buscamos realizar a proposição e validação de uma atividade didática de natureza investigativa para ensino de luz e cores nos anos iniciais do ensino fundamental. Para validação, a sequência de ensino desenvolvida foi aplicada com 18 alunos de uma turma do 8° período do curso de pedagogia da Universidade Federal de Alagoas - UFAL. Como instrumento de coleta de dados, foram utilizados questionários. Os dados dos questionários foram analisados e os resultados evidenciaram que a sequência de ensino investigativo elaborada se mostrou como uma ótima ferramenta para o ensino de ciências, na turma em questão, e que o método de ensino investigativo estimula a curiosidade, os questionamentos e a interação com a turma.
Brine Shrimp Lethality Test (BSLT) of 96% Ethanol Extract of Ande-ande Lumut (Selaginella doederleineii) Leaves
Authors: Difa Prasticha Yunita , Surahmaida Surahmaida
Published: November 2024

Selaginella doederleineii is a fern plant that is efficacious for treating coughs, pneumonia and broken bones. Leaves are the primary medicinal parts. However, there has been no research regarding the toxicity of Selaginella doederleineii leaves. This study aims to evaluate potential toxicity of 96% ethanol extract of Selaginella doederleineii leaves against shrimp larvae (Artemia salina Leach) using the Brine Shrimp Lethality Test (BSLT) method. The toxicity value is shown by the LC50 value. This research method includes the extraction stage, larvae hatching stage, stock solutions and concentration dilutions of the extract preparation, toxicity test and LC50 value calculation. The toxicity test using 10 Artemia salina shrimp larvae were exposed to each test concentration (0 ppm, 1 ppm, 2 ppm, 3 ppm, 4 ppm, 5 ppm) in triplicate. Larval mortality was assessed after 24 hours to calculate mortality percentage and LC50. The results showed that the LC50 value for the 96% ethanol extract of Selaginella doederleineii was 12.0221 ppm, indicating very toxic. It can be concluded that Selaginella doederleineii leaves exhibits significat toxicity to brine shrimp and potential to be developed as a raw material for anti-cancer drugs.
Flora Diversity as An Attraction at Edu-Tourism Villa Tani Indonesia
Authors: Tahri Tahri , Marianingsih Pipit
Published: November 2024

Based on genetics and response to the environment, a diversity of flora can grow in an area, including in Villa Tani Indonesia. Villa Tani Indonesia is one of the tourist attractions, located in the Cilegon-Banten, which offers educational tourism based on agro-farming and animal husbandry. The plants cultivated at Villa Tani Indonesia utilized for educational tourism and post-harvest economy, thus some are annual plants but there are also annual plants that can be harvested in one growing season. The observation method was used to identify and to inventory the diversity of flora at Villa Tani Indonesia, which is used as an edu-tourism attraction. Based on the research showed that there was a diversity of flora of 27 species consisting of 16 families, namely Vitaceae, Cucurbitaceae, Rutaceae, Myrtaceae, Solanaceae, Fabaceae, Oxalidaceae, Malvaceae, Poaceae, Sapotaceae, Caricaceae, Rosaceae, Convolvulaceae, Amaranthaceae, Brassicaceae, and Gnetaceae. The highest number of individu was found in Zea mays, Ipomoea reptans, Ipomoea aquatic, Amaranthus tricolor, and Brasicca rapa.
Local Knowledge and Use of Plants In The Kenduri Sko Traditional Ceremony In The Community Of Hamparan Rawang District, Sungai Penuh City, Jambi Province, Indonesia
Authors: Marsanda Firda Dwi , Adriadi Ade , Witono Joko Ridho
Published: November 2024

Upacara Adat Kenduri Sko adalah tradisi turun temurun yang diwariskan oleh nenek moyang dan yang dicirikan dengan penobatan gelar adat, membersihkan benda-benda pusaka. Dalam upacara adat Kenduri Sko menggunakan tumbuhan sebagai simbol dalam adat dan untuk membersihkan benda-benda pusaka. Penelitian ini bertujuan untuk mengetahui jenis tumbuhan yang digunakan dalam upacara adat Kenduri Sko, mengetahui nilai indeks guna (Use value) dan bagian tumbuhan yang dimanfaatkan (Plant Part Value) pada tumbuhan yang digunakan dalam upacara adat Kenduri Sko. Penelitian ini dilaksanakan pada bulan Februari-Juli 2024. Hasil penelitian menyatakan terdapat 16 jenis tumbuhan yang tergolong dalam 10 famili yang digunakan dalam upacara adat Kenduri Sko Kecamatan Hamparan Rawang, dengan nilai indeks guna tertinggi yaitu 1 dan bagian tumbuhan yang digunakan dengan persentase tertinggi yaitu daun (38%).
Development of classification and criteria of quality and safety of autologous platelet concentrates for regenerative injection therapy in traumatology and orthopedics
Authors:   State Institute of Traumatology and Orthopedics, National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine, Holiuk Ye. , Strafun S. , Lushchii O. , Ostapenko T. ,   Ukrainian Scientific and Practical Center of Endocrine Surgery, Transplantation of Endocrine Organs and Tissues of the Ministry of Health of Ukraine, Kyiv, Ukraine, Smorzhevskyi V. ,   O. O. Shalimov National Scientific Center of Surgery and Transplantology of the National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine
Published: November 2024

Regenerative injection therapy (synonyms – orthobiology, prolotherapy) is considered the newest direction of orthopedics, which studies the use of cell technologies and new materials to ensure reparative or physiological regeneration in various diseases and injuries of the musculoskeletal system. The substantiation of the therapeutic effectiveness of autologous platelet concentrates, depending on the manufacturing features and characteristics of these biotechnological products, remains an urgent problem.
The purpose of the study was to develop the classification and quality and safety criteria of autologous platelet concentrates for regenerative injection therapy in traumatology and orthopedics.
Material and methods. A comparative study of 778 autologous platelet concentrates of various types, made from the blood of patients with osteoarthritis and aseptic necrosis of the hip and knee joints due to damage to ligaments and tendons, osteochondrosis of the spine, was conducted. In biotechnological products, the content of platelets and leukocytes was determined, the ratio of platelets and leukocytes among themselves and relative to their content in peripheral blood was calculated, respectively. During the production of autologous platelet concentrates, the visual characteristics of cell sediment and plasma were evaluated. Products of platelet cryolysates were subject to microbiological testing.
Results. The classification of autologous platelet concentrates according to the concentration of platelets and leukocytes was developed, as well as the quality and comprehensive safety criteria of cellular forms of autologous platelet concentrates were determined: platelet index of autologous platelet concentrate, leukocyte index of autologous platelet concentrate, leukocyte-platelet index of autologous platelet concentrate. Visual characteristics of platelet concentrates were established: “ideal”, “classic”, “erythrocyte”, “low cell” and “alimentary” phenotype. Based on the results of a microbiological study, the safety of platelet concentrates for intra-articular administration to orthopedic and trauma patients was established.
Conclusions. The developed classification of biotechnological products from human peripheral blood, as well as their quantitative and qualitative criteria, is the basis for the development of differentiated and personalized approaches to their use in diseases and injuries of the musculoskeletal system.
Prospects for cytokinesis-block micronucleus cytome assay in the comprehensive evaluation of cellular senescence markers
Authors:   Institute of Genetic and Regenerative Medicine, M. D. Strazhesko National Scientific Center of Cardiology, Clinical and Regenerative Medicine, National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine, Ustymenko Alina , Kyryk Vitalii ,   D. F. Chebotarev State Institute of Gerontology, National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine, Tsupykov Oleg , Parkhomenko Olexander ,   M. D. Strazhesko National Scientific Center of Cardiology, Clinical and Regenerative Medicine, National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine
Published: November 2024

In modern pathophysiology and clinical medicine, the search for new, more reliable cellular and molecular biomarkers remains a pressing issue, enabling the assessment of premature aging processes and predicting the risk or severity of many diseases. DNA damage, manifested in particular as micronuclei, is a key factor in initiating the aging process, as it reflects genomic instability. The loss of genomic stability due to physical, chemical, and biological genotoxic factors can lead not only to premature aging of the organism but also to chronic inflammation and the development of neurodegenerative and cardiovascular diseases, diabetes, cancer, and other conditions. Furthermore, studying genomic instability in stem cells is crucial for the development of cellular therapies aimed at slowing aging and treating related diseases.
The cytokinesis-block micronucleus assay (CBMN) is proposed as a tool for elucidating the molecular mechanisms linking DNA damage with cellular senescence and aging outcomes at the organismal level. This method provides a range of quantitative indicators for a comprehensive assessment of cellular senescence manifestations, which can be utilized as potential biomarkers for disease risk evaluation and monitoring of disease progression, including as a marker of high cardiovascular risk in patients who have experienced acute cardiac conditions.
Kilka uwag o srebrnym pierścieniu z inskrypcją z Tumu pod Łęczycą
Authors: Sosnowski Miłosz
Published: November 2024

Artykuł stanowi próbę nowego objaśnienia inskrypcji („Tot vivas felix, quot vivit tempora fenix”) na srebrnym pierścieniu romańskim odkrytym na grodzisku w Tumie pod Łęczycą w 2009 r. Dotychczasowa interpretacja wskazywała na chrystologiczne konotacje napisu oraz jego wyjątkowość wśród inskrypcji na pierścieniach. Autor artykułu wskazuje natomiast na jego bliskie analogie formalne i treściowe w piśmiennictwie średniowiecznym, zwłaszcza w formułach salutacyjnych, zarówno w okresie poprzedzającym hipotetyczne powstanie pierścienia w XI–XII w., jak i w okresie późniejszym. Analogie te pozwalają domyślać się nie tylko znaczenia napisu na pierścieniu, ale też jego zamierzonej funkcji oraz środowiska intelektualnego zleceniodawcy.
Witold Świętosławski, Prusowie i Wielki Step. Ślady tradycji stepowych koczowników u zachodnich Bałtów
Authors: Nowakiewicz Tomasz
Published: November 2024

Recenzja
Mirosław Bogdan, Dzieło opata z Saint-Denis a architektura gotycka południowej Polski. Mistyka, cystersi, ołtarz. L’oeuvre de l’abbé de Saint-Denis et l’architecture gothique au sud de la Pologne. La mystique, les cisterciens, l’autel
Authors: Jarzewicz Jarosław
Published: November 2024

Recenzja
Józef Piłatowicz, Elektryfikacja Polski w dwudziestoleciu międzywojennym
Authors: Sadłowski Przemysław
Published: November 2024

Recenzja
Raimo Pullat, Risto Pullat, Vodka Sea: the illicit alcohol trade in the Baltic Sea Region between the World Wars
Authors: Klonder Andrzej
Published: November 2024

Recenzja
Sławomir Łotysz, Pińskie błota. Natura, wiedza i polityka na polskim Polesiu do 1945 roku
Authors: Pospiszyl Michał
Published: November 2024

Recenzja
Exploring the Relation Between Lifestyle Choices and the Occurrence of Colorectal Cancer Disease
Authors: E Alabd Ruaa , Mohsin Forat Yahya , Oufi Hayder , Ibrahim Besmah M. Ali
Published: November 2024

Colorectal cancer is among the leading causes of cancer mortality worldwide. The occurrence of CRC has been associated with various lifestyle risk behaviors about major modifiable risk factors, which include dietary patterns, physical activity, smoking status, and alcohol intake. This study aimed to investigate the association of these parameters of lifestyle with the incidence of CRC. In this case-control study, a total of 140 individuals were enrolled: 70 subjects diagnosed with CRC and 70 controls (1st degree relative). The data were obtained by structured questionnaires and medical records, and analyzed by chi-square tests and logistic regression methods. The results indicated that, compared with their counterparts, physical inactivity, low exercise, smoking, and alcohol drinking are significantly associated with an increased risk for CRC. Besides, other dietary habits, such as high consumption of processed meat and low intake of vegetables and fruits, were major characteristics of the cases of CRC. It has been estimated that promoting healthy lifestyle choices could reduce excess CRC risk by more than 70%. This study underscores the critical role of lifestyle modifications in preventing CRC.
Analiz vozmozhnostej metoda ocenki krivoj «potok–ob"em» po izmeneniyu ee formy pri obstrukcii bronhov
Authors: Десяцкова Е. М. , Греченко В. В. , Соболева В. В.
Published: November 2024

Pri obstrukcii bronhov krivaya «potok–ob"em» imeet harakternuyu vognutuyu formu, odnako dannomu priznaku ne udelyayut dolzhnogo vnimaniya. Analiz skorostnyh pokazatelej funkcii vneshnego dyhaniya (FVD), takih kak pikovaya ob"emnaya skorost' vydoha (POS) i maksimal'nye ob"emnye skorosti vydoha (MOS), pozvolit rasshirit' diagnosticheskie vozmozhnosti spirometrii. Cel' raboty — provesti sravnitel'nyj analiz diagnosticheskoj effektivnosti metodov ocenki krivoj «potok–ob"em» po izmeneniyu ee formy na fone obstruktivnyh narushenij. Oceneno 540 prob FVD pacientov (234 muzhchiny 57 [36; 67] let i 306 zhenshchin 59 [44; 69] let), dlya kazhdogo opredeleno procentnoe otnoshenie ploshchadej pod fakticheskoj krivoj i krivoj predpolagaemoj normy, rasschitan ugol, obrazovannyj krivoj, opredeleno procentnoe otnoshenie fakticheskih MOS s predpolozhitel'no normal'nymi, rasschitany otreznye tochki s cel'yu razgranicheniya obstruktivnyh narushenij i normy. Sformirovano zaklyuchenie o nalichii ili otsutstvii u pacienta obstrukcii bronhov. Rezul'taty sravnivali s zaklyucheniyami, poluchennymi s pomoshch'yu sistemy Knudson, s raschetom operacionnyh harakteristik testa otnositel'no standarta. Pokazano, chto metody ocenki ugla β i obshchej vognutosti krivoj obladayut vysokimi znacheniyami chuvstvitel'nosti (87,8% i 95,6% sootvetstvenno), a ocenka ploshchadi pod krivoj «potok–ob"em» (AEX-FV) obladaet vysokim znacheniem specifichnosti (88,6%). Takim obrazom, prodemonstrirovana dostatochnaya diagnosticheskaya effektivnost' metodov ocenki krivoj po izmeneniyu ee formy. Odnako ispol'zovanie etih metodov v otryve ot prinyatyh sistem rascheta dolzhnyh ne viditsya celesoobraznym. Logichnym predstavlyaetsya sovmestnoe ispol'zovanie sistemy rascheta dolzhnyh i odnogo iz metodov ocenki krivoj po forme.
Detection of Antibody Titers Against New-Castle Disease Virus (ND) and Monocyte Profile in Free-Range Chickens (Gallus domesticus) at a Farm in Permata Village, Tilongkabila Sub-district, Bone Bolango District
Authors: Suaiba Zachrianty , Djuna Lamondo , Wirnangsi Din Uno , Yuliana Retnowati , Margaretha Solang , Kristina Dwi Wulandari
Published: November 2024

Abstract: This study aims to determine the presence of Newcastle Disease (ND) virus antibody titers and the percentage of monocyte cells in native chickens (Gallus domesticus) at a farm in Permata Village, Tilongkabila Subdistrict, Bone Bolango Regency. The method used in this research is qualitative descriptive. Antibody titer data were obtained from the results of the HI (Haemagglutination Inhibition) test, while the percentage of monocyte cells was determined using 10% Giemsa staining with parallel track counting.The results showed that out of 50 samples, 10 samples tested positive for antibody titers (20%), while 40 samples tested negative (80%). For positive antibody titer samples, leukocyte count totaled 3,310, with 250 monocytes, yielding a percentage of 7.55%. For negative samples, leukocyte count totaled 10,560, with 360 monocytes, resulting in a percentage of 3.20%, which falls within the normal range of monocyte cell values.
Soap films: from the Plateau problem to deformable boundaries
Authors: Bevilacqua Giulia , Lussardi Luca , Marzocchi Alfredo
Published: November 2024

A review on the classical Plateau problem is presented. Then, the state of the art about the Kirchhoff-Plateau problem is illustrated as well as some possible future directions of research.
Artificial neural network for solving flow shop optimization problem with sequence independent setup time
Authors: Sadki Hajar , Allali Karam
Published: November 2024

In this paper, we will study the permutation flow shop scheduling problem (PFSSP) with sequence independent setup time (SIST). This constraint is the most common encountered in industrial production. In this case, the SIST constraint depends on the technology nature of the machine, as well as the means used to prepare it for the execution of a new job. The purpose of this paper is to develop an artificial intelligence system and to train a neural network model for solving the flow shop scheduling problem. The objective function is to minimize the total completion time, which is known as makespan. The latter is an important task in manufacturing systems. The paper begins by suggesting an exact and four approximate methods: a mixed integer linear programming (MILP), an artificial neural network (ANN), and three e cient heuristics. The first heuristic is based on Johnson’s rule algorithm (ABJR), the second on the Nawaz-Enscore and Ham algorithm (NEH), and the last on the greedy randomized adaptive search procedure algorithm (GRASP). We aim to verify the e ectiveness of our resolution algorithms by considering randomly generated instances with n jobs and m machines in the flow shop factory. Our goal is to determine the optimal sequence of n jobs to be scheduled on m machines. The paper moves to the comparison between the studied heuristics. The numerical results demonstrate that the NEH algorithm outperforms the other approximate methods for our considered problem. Indeed, the NEH heuristic performs a success rate of 82.81% and achieves a minimum relative percentage deviation value of 0.0139%. It was observed that ANN method outperforms GRASP and gives sometimes best results than ABJR. The numerical simulations align with our theoretical postulations given by RPD values.
Dynamic Interest Portrait of Community Users based on Three-way Fuzzy Concept Lattices
Authors: Kai Wang
Published: November 2024

Aiming at the multi-granularity knowledge discovery of users in online community, a method of dynamic user interest portrait based on Three-way Fuzzy Concept Lattice (3WFCL) is proposed to reveal the relationship between long-term and short-term interest drift, which improves the accuracy of the user portrait from a fuzzy perspective. Firstly, the label topic matrix of community users is constructed based on the topic analysis and the dynamic interest modelling is realized. Secondly, the environment migration index is calculated by extracting the topic and sentiment characteristics of the user environment. Meanwhile, interest inheritance is introduced into the calculation of interest characteristics, and interest attenuation vector is established to perceive the short-term interest label set dynamically. Finally, the membership degree of the three-way fuzzy interests is put forward into the multi-feature concept modelling of the long-term and short-term interest labels. Afterwards, the multi-granularity fuzzy association rules are generated to complete the multi-granularity characterization of differentiated interests by constructing the three fuzzy formal contexts. The effectiveness of the proposed method is validated on real data sets. The results show that it is of great significance to utilize the three-way fuzzy concept analysis into user portrait modelling, which is helpful to mine semantic association information and improve the analysis ability of fine-grained interest hierarchy.
Navigating Sustainable Transformation in the Fashion Industry: The Role of Circular Economy and Ethical Consumer Behavior
Authors: Krywalski-Santiago Joanna
Published: November 2024

Objective

This paper explores the sustainable transformation of the fashion industry, focusing on integrating circular economy principles and promoting ethical consumer behavior. It seeks to analyze the environmental, social, and economic impacts of the industry’s operations and identify opportunities for adopting more sustainable practices.

Methodology

A qualitative research approach is used, with expert interviews providing insights into current trends, challenges, and opportunities for sustainable transformation in the fashion sector. The data were analyzed with MAXQDA.

Findings

The research reveals an increasing awareness among both consumers and industry stakeholders regarding the importance of sustainability. This shift is motivated by the recognition of the industry’s significant ecological footprint and the ethical concerns associated with its supply chains. Responsible consumption patterns, such as the rise in second-hand shopping and ethically produced fashion, are becoming more popular. Additionally, circular economy practices–such as recycling materials, designing for longevity, and reducing waste–are identified as key strategies for reducing environmental impacts and improving resource efficiency. Despite these positive developments, there are ongoing challenges, including the need for increased transparency, overcoming greenwashing, and the development of stricter regulatory frameworks.

Value Added

This paper contributes to the growing body of knowledge on sustainable fashion by highlighting the intersection of consumer behavior, industry practices, and circular economy principles. It emphasizes the critical role of collective action and systemic change in fostering a sustainable transformation within the fashion industry.

Recommendations

The paper provides actionable recommendations for industry stakeholders, policymakers, and consumers, encouraging the promotion of transparency, innovation, and regulatory measures to ensure accountability and drive the widespread adoption of sustainable practices.
Novel Approach to Making Environmentally Friendly Plaster: A Moisture Buffer Value of Plaster Made of Wastepaper and Different Glues
Authors: Nutt N. , Nei L. , Muoni H. , Kubjas A. , Raamets J.
Published: November 2024

This article deals with the reuse of wastepaper. Three components were used to make traditional paper plaster: wastepaper, glue, and water. Whether the glues used to make paper plaster and the quantities of those glues have an impact on the moisture buffering value (MBV) of paper plaster was studied. The scope of the Nordtest method is to evaluate the MBV for materials exposed to indoor air. The test intended to simulate daily variations with relative humidity between 75 % during 8 hours and 33 % during 16 hours.

The test specimen was made according to the recipe which contained the following: waste-paper (newspaper paper), three different types of glue (potato starch (Amylum Solani) C6H10O5, wallpaper glue Metylan Universal Premium (produced by Henkel), and methylcellulose C6H7O2(OH)x(OCH3)y, and water. Different percentages of glue were used in the specimens. Potato starch (Amylum Solani) C6H10O5 clearly increased the moisture buffering ability.

The tests performed showed that the composition and quantity of glue affected the MBV of paper plaster. The MBV of all the specimens remained in the range of 2.08–2.48 [g/(m2·%RH)@8/16h]. The largest MBV was 2.48[g/(m2·%RH)@8/16h], and it was registered in the case of a mixture that had a glue made from 100 g of potato starch (Amylum Solani) C6H10O5 per litre of water and the smallest MBV was 2.08[g/(m2·%RH)@8/16h], and it contained glue mixture made of 20 g methylcellulose per litre of water. As a result of the current study, an environmentally friendly plaster with high moisture buffer value using wastepaper as a component of this material was developed.
The Practical Implementation of Hydrogen-Based Sustainable Power Generation Backup
Authors: Backurs A. , Jansons L. , Zemite L. , Laizans A.
Published: November 2024

Hydrogen fuel cell backup power is a modern way to ensure an uninterrupted and decentralised supply of electricity. A stationary and mobile fuel cell, commonly referred to as a hydrogen generator, is used to produce electricity during power outages or other emergency situations. These fuel cell backups are designed to provide a reliable and efficient source of electricity for critical loads, such as hospitals, data centres, and other critical infrastructures. Hydrogen generators are typically used in situations where a reliable and efficient source of electricity is needed, and in cases when conventional diesel generators are not the priority. These generators can also be used in remote locations where access to the grid is limited or unavailable, or in applications where the use of fossil fuels is not practical or desirable. The article covers the thematic related to comparison of diesel and hydrogen generators, with regards to advantages and shortcomings of the latter, as well as provides an insight into possible use of hydrogen generators in Latvia.
Air Flow Analysis for Triply Periodic Minimal Surface Heat Exchangers
Authors: Kancs A.
Published: November 2024

Due to the increasing popularity of additive manufacturing technologies, more varied and complex shapes of heat exchangers can be produced that can be optimised to be more compact and efficient. In this paper, a triply minimal periodic surface – gyroid structure – is designed to study the applicability of such structures in compact air-to-air heat exchangers used in residential ventilation recuperation systems. Gyroid surface structures could potentially decrease overall heat exchanger size, pressure and increase heat transfer. Several geometry variations with different flow rate values were analysed to compare the efficiency of heat exchanger designs. Additionally, a literature review was conducted to identify more adaptable geometric parameters of the gyroid structure. To calculate the pressure difference, temperature and heat transfer in each variation, SolidWorks Flow Simulation was used. The results showed that by using gyroid structures, heat exchanger energy transfer can be optimised for required back pressure and heat transfer, while reducing the overall dimensions, compared to conventional heat exchangers. By incorporating low cost, printed thermal recuperators, thermal efficiency of residential buildings can be improved. Suitable materials, manufacturing methods and application limitations are discussed.
Operational Management of Technological Processes for Preparing Aircraft for Departure at the Airport as a Multi-Criteria Task
Authors: Zabirov A. , Soldatova J. , Zabirov Z. , Shestakov A.
Published: November 2024

Analysis of the statistics on the regularity of aircraft departures from the airport shows that one of the reasons for delays is poor operational management, leading to deviations from established norms in the timing of individual technological operations preparing aircraft for departure. This article presents an approach to solving this problem, which is considered a multi-criteria task. To address it, an imitation model in the form of a complex of modules has been developed. A corresponding algorithm for the functioning of each module has been devised. To ensure the necessary conformity of the model to real conditions, a check of the technological process variables for stochasticity has been conducted based on daily flight plans of the airport, using Wilcoxon and Smirnov-Kolmogorov criteria. Based on the timing of the duration characteristics of individual technological operations for servicing flights of different aircraft types under various conditions, a “Random Variable Generator” scheme has been developed. Frequency polygons and probability distribution functions of deviations in aircraft arrivals, obtained through statistical analysis, are presented in the paper.
POTENSI PASTA GIGI MENGANDUNG EKSTRAK ETANOL BIJI HIJAU KOPI ROBUSTA (Coffea canephora) DALAM MENGHAMBAT PERTUMBUHAN Streptococcus mitis SECARA IN VITRO
Authors: Rizki Miftakhur , Wahyukundari Melok Aris , Praharani Depi
Published: November 2024

Salah satu bakteri koloni primer yang membentuk plak gigi adalah Streptococcus mitis yang memiliki wall-associated adhesin yang membantu perlekatan dan kolonisasi. Plak gigi yang terus terakumulasi menyebabkan penyakit infeksi rongga mulut seperti penyakit periodontal dan karies Untuk pencegahan akumulasi plak, dilakukan kegiatan kontrol plak, salah satunya dengan menyikat gigi yang dibantu  pasta gigi. Pasta gigi mengandung berbagai bahan aktif termasuk bahan antibakteri. Ekstrak etanol biji hijau kopi robusta (Coffea canephora) memiliki kandungan antibakteri seperti kafein, trigonelin, asam klorogenat, flavonoid, saponin, dan terpenoid. Tujuan penelitian ini adalah untuk menganalisis potensi pasta gigi yang mengandung ekstrak etanol biji hijau kopi robusta konsentrasi 12,5%, 25%, dan 50% dalam menghambat pertumbuhan S. mitis. Jenis penelitian yaitu penelitian eksperimental laboratoris secara in vitro dengan rancangan the post-test-only control group design. Pengujian potensi antibakteri dilakukan dengan agar disk-diffusion test pada media yang telah diinokulasi bakteri S. mitis dengan 5 kelompok sampel dan 4 kali pengulangan. Pengukuran zona hambat setelah 24 jam inkubasi. Data kemudian dianalisis menggunakan SPSS. Diperoleh kesimpulan bahwa pasta gigi  yang mengandung ekstrak etanol biji hijau kopi robusta 12,5%, 25%, dan 50% memiliki potensi dalam menghambat pertumbuhan S. mitis, serta terdapat hubungan antara konsentrasi ekstrak yang diformulasikan dengan besar zona hambat yang dihasilkan.
Preclinical Dentistry Students' Knowledge And Attitude Towards Traumatic Dental Injuries (TDI) In Children At Syiah Kuala University
Authors: Yulina Vera , Rifki Ayudia , Fitri Maida
Published: November 2024

Traumatic dental injuries (TDI) merupakan kondisi gawat darurat yang membutuhkan perawatan segera. Keberhasilan perawatan TDI salah satunya ditentukan oleh ketepatan pertologan pertama saat golden periode. Di provinsi Aceh, Indonesia  belum ditemukan data epidemiologi tingkat pengetahuan dan sikap mahasiswa Fakultas Kedokteran Gigi (FKG) terhadap TDI. Tujuan penelitian ini adalah untuk menggali pengetahuan dan sikap mahasiswa Preklinik FKG terhadap TDI pada anak. Seluruh mahasiswa preklinik FKG USK (n=258; total responden = 234; 90.7%) diikutsertakan dalam penelitian ini untuk mengisi kuesioner secara online yang sebelumnya telah dilakukan uji validitas dan reliabilitas. Data dianalisis menggunakan software SPSS untuk dilakukan uji chi-square dengan tingkat kepercayaan 95% (p 0,05). Persentase paling rendah terkait pengetahuan dan sikap terhadap TDI terdapat pada mahasiswa tingkat pertama, masing-masing 68% dan 54%. Terdapat perbedaan signifikan tingkat pengetahuan terkait penyebab utama TDI (61.1%), urgensi mencari pertolongan pertama kasus avulsi (85.5%), cara memegang gigi avulsi (91.5%), pemilihan media transport (72.2%), media penyimpanan (58.5%), dan urgensi mencari pertolongan pertama fraktur gigi (60.3%). Sementara terkait sikap, perbedaan signifikan terdapat pada tindakan untuk mencari pertolongan pertama, reimplantasi, dan sikap memilih media penyimpanan, masing-masing 60.7%, 62.8%, dan 55.1%. Tingkat pengetahuan dan sikap responden terhadap TDI rendah. Perlu dilakukan evaluasi metode pembelajaran, pelaksanaan pelatihan dan evaluasi kurikulum.
UJI PENGARUH PENAMBAHAN EKSTRAK DAUN SIRSAK (Annona muricata L.) PADA ANTIBIOTIK AMOKSISILIN TERHADAP PERTUMBUHAN BAKTERI Enterococcus faecalis
Authors: Andayani Ridha , Mubarak Zaki , Nabiela Haya
Published: November 2024

Enterococcus faecalis merupakan bakteri Gram positif yang sering dijumpai pada infeksi endodontik. Faktor virulensi  Enterococcus faecalis sering dikaitkan dengan kemampuannya dalam memproduksi enzim seperti, gelatinase dan β-laktamase yang telah dilaporkan memiliki peran menghambat kerja antibiotik hingga kejadian resistensi antibiotik, seperti amoksisilin. Pemanfaatan bahan herbal dengan kombinasi antibiotik dianggap menjadi alternatif baru untuk mengatasi resintensi antibiotik. Salah satunya adalah dengan pemanfaatan daun sirsak. Daun sirsak (Annona muricata L.) mengandung berbagai senyawa metabolik sekunder yang memiliki efek antibakteri  seperti senyawa flavonoid, alkakoid, terpenoid, tannin, dan saponin. Tujuan penelitian ini adalah untuk mengetahui pengaruh penambahan ekstrak daun sirsak (Annona muricata L.) pada antibiotik amoksisilin. Penelitian ini menggunakan metode post-test only group. Sampel yang digunakan adalah ekstrak daun sirsak dengan konsentrasi 0,5%, 1%, 2%, dan 3% dan penelitian dilakukan dengan metode difusi sumuran. Data hasil diameter zona hambat dianalisis menggunakan uji One way Anova menunjukkan adanya perbedaan bermakna kelompok perlakuan dengan kelompok kontrol (p0,05). Berdasarkan hasil penelitian ini dapat disimpulkan bahwa penambahan ekstrak daun sirsak  (Annona muricata L) pada antibiotik amoksisilin berpengaruh terhadap pertumbuhan Enterococcus faecalis.
Melampaui tradisi: Analisis galian teks untuk data kualitatif berskala besar
Authors: Burhan Omar K.
Published: November 2024

Kemajuan teknologi digital telah memungkinkan akses dan analisis data skala besar, memberikan peluang bagi peneliti psikologi untuk menggali wawasan baru dari data kualitatif seperti media sosial dan artikel berita. Namun, metode tradisional memiliki keterbatasan dalam menangani volume data yang besar. Galian teks (text mining) hadir sebagai solusi yang efisien, menggunakan algoritma untuk menemukan pola dan tema dalam kumpulan teks besar. Artikel ini memperkenalkan teknik galian teks untuk menganalisis data kualitatif skala besar dengan studi kasus dua edisi Jurnal Psikologi Ulayat (JPU). Melalui analisis frekuensi kata, awan kata, bi-gram, dan pairwise correlation, lima tema utama teridentifikasi: (1) psikologi berbasis Indonesia, (2) kesehatan mental, (3) hubungan antar individu dan keluarga, (4) pengukuran psikometris, dan (5) fenomena sosial terkait fandom dan budaya pop. Ilustrasi ini menunjukkan potensi galian teks sebagai pendekatan efisien untuk mengidentifikasi pola dan tema dalam data kualitatif berskala besar.
Projection of Climate Extreme Indices Based on Representative Concentration Pathways (RCP) in Aceh Province
Authors: Subiyantoro Fitrohim , Abdullah Faisal , Ismail Nazli , Gede Arya Putra I Dewa , Grefyolin Simbolon Theresia
Published: November 2024

Representative Concentration Pathways (RCP) scenarios are based on assumptions about the future development of radiative forcing. There are 4 RCP scenarios, but only 2 RCP scenarios are used in this study, RCP 4.5 and RCP 8.5. The aims are to identify characteristics and percentage changes in extreme climate indices in the future. CMIP5 model data such as CCSM4, IPSL-CM5A-LR, IPSL-CM5A-MR, IPSL-CM5B-LR and NorESM1-M were used. The model data was downscaled using a statistical method, and bias correction was based on observational data from five BMKG stations in Aceh Province for the historical period (2001-2005). Subsequently, the observation data and bias-corrected model data for extreme climate events were identified based on the Expert Team on Climate Change Detection and Indices (ETCCDI). The extreme climate indices utilized in this study are consecutive rainy days (CWD), consecutive dry days (CDD), total annual rainfall (Prcptot), monthly maximum temperature (TXx), and monthly minimum temperature (TNn). The results show that the CDD, Prcptot, TXx and TNn climate indices tend to increase in 2021 – 2100 periods. Meanwhile, the CWD decreased. Based on the historical period, all extreme climate indices increased significantly in 2021 - 2100 except TXx, which decreased in 2021 – 2040.
Physical and Chemical Properties of Gayo Coffee Brewed by Boiling Method with Variation of Particle Coffee Ground
Authors: Yufita Evi , Muhammad Shadiq Maula Teuku , Gunawati Gunawati , Lloyd Woodfield Peter , Yusibani Elin
Published: November 2024

The effect of coffee ground particle size by the boiling method on the values of physical and chemical parameters is studied. The coffee used is Arabica (Luwak, wine, honey) and Robusta from the Gayo Highlands, Aceh Province, Indonesia. Extraction of the coffee brew uses the boiling method with different particle sizes of coffee grounds (fine and coarse). The caffeine content in the coffee brew is identified using the FieldSpec4 Hi-Res Spectrometer. The particle size of coffee grounds affected the coffee brew's physical properties and caffeine content. The physical properties in the form of the pH value of Arabica coffee brew are lower than Robusta in a range from 4.87 to 4.97 and 5.13 to 5.28, respectively. The pH of coffee brew with fine particle sizes is slightly higher than for coarse ones for Robusta coffee brew. The density of the brew is in the vicinity range of 0.99 g/cm3. Arabica and Robusta brews differ in viscosity and caffeine release, influenced by coffee particle size. Coarse particles yield more caffeine in Arabica, while fine particles release more in Robusta, demonstrating the impact of grind size on caffeine extraction in coffee.
Impacto da pandemia da COVID-19 na saúde mental e nos estilos de vida de universitários
Authors: Oliveira Renata Marques de , Rodrigues Taliane Cristina Barros , Oliveira Adriana Marques de , Santos Jair Lício Ferreira , Furegato Antonia Regina Ferreira
Published: November 2024

Objetivo: Avaliar a saúde mental e os estilos de vida de universitários, na pandemia da Covid-19, identificando o perfil pessoal e acadêmico associado. Métodos: Estudo epidemiológico transversal conduzido com 571 universitários de uma Universidade Federal do Brasil. Eles responderam um questionário virtual. Resultados: Identificou-se elevado nível de estresse e reduzido bem-estar entre os universitários. Cerca de metade referiu solidão e a maioria pontuou para depressão. O perfil dos universitários, piores avaliados quanto à saúde mental, era do sexo feminino, menor idade, estudante de graduação, ausência de vínculo empregatício, aumento dos conflitos familiares e diminuição da renda na pandemia. Os estilos de vida desse público foram alterados, na pandemia, com aumento de exposição às telas e prevalência elevada de insônia. Conclusão: Este estudo mostra a dificuldade dos universitários de se adaptarem ao contexto pandêmico, destacando-os como vulneráveis ao adoecimento psíquico. Destaca-se a importância de estímulo aos hábitos saudáveis nas ações de promoção, prevenção e recuperação da saúde mental dos universitários.
Caracterização da transição de cuidados hospital/domicílio de pacientes adultos internados em hospital de referência
Authors: Furtado Clara Batista Bonini , Siqueira Júlia Souza , Soares Querem-Hapuque , Damaceno Daniela Garcia , Esteves Larissa Sapucaia Ferreira
Published: November 2024

Objetivo: Caracterizar o perfil dos pacientes que foram submetidos à Transição de Cuidados hospital/domicílio e os desfechos pós-alta. Métodos: Pesquisa quantitativa, retrospectiva, transversal realizada em um hospital de referência no Oeste paulista. As informações foram obtidas no banco de dados do Serviço Integrado de Humanização, e os registros, entre 2018 a 2022, foram analisados por meio da estatística descritiva e inferencial. Pesquisa autorizada pelo Comitê de ética (CAAE 64589722.2.0000.5515). Resultados: No período citado foram realizadas 400 transições de cuidados, a maioria no ano de 2020 (n.127/31,8%), maior parte era de homens (n.258/64,5%), com internação superior a 30 dias (n.184/46,0%), e a média de idade foi de 63,3 anos (+/- 16,955). Dentre os pacientes, n.371 (92,8%) possuíam cuidador estabelecido, e houve o contato da unidade hospitalar com a atenção primária em n.306 (76,5%) dos casos. Em relação a complicações após alta, n.63 pacientes foram reinternados em menos de 30 dias e n.18 pacientes vieram a óbito. As variáveis sexo, idade, tempo de internação e presença de dispositivos médicos no momento da alta hospitalar obtiveram significância estatística quando analisados na perspectiva de óbito pós-alta. Conclusão: O processo de Transição de Cuidados hospital/unidade de saúde se mostrou eficaz para a sobrevida dos pacientes.
Consumo de bebidas alcoólicas em uma comunidade extrativista marinha sob a ótica da vulnerabilidade
Authors: Vera Sinara , Alves Vânia Sampaio , Campiolo Sofia
Published: November 2024

Objetivo: Analisar situações de vulnerabilidade relacionadas ao consumo de bebidas alcoólicas em uma comunidade tradicional extrativista marinha. Métodos: Estudo qualitativo, transversal e descritivo. Os dados foram coletados através de quatro Grupos Focais, com a participação de 45 mulheres pescadoras e marisqueiras de uma comunidade extrativista marinha na Bahia e analisados a partir da Análise de Conteúdo. O estudo foi aprovado por Comitê de Ética em Pesquisa. Resultados: Foram identificadas seis categorias temáticas intituladas: percepções sobre o consumo elevado de bebidas alcoólicas; preocupações com os riscos e prejuízos causados pelo consumo de bebidas alcoólicas; interesse em desenvolver ações preventivas; dificuldades de acesso à educação; dificuldades de acesso aos serviços de saúde e cumprimento de normas e leis relativas ao comércio de bebidas alcoólicas. Estas categorias foram analisadas sob a ótica da vulnerabilidade, sendo que todas apresentam alguma correspondência com os componentes da vulnerabilidade. Conclusão: A presença de condições de vulnerabilidade na dinâmica cotidiana das pessoas indica maior suscetibilidade e danos relativos ao consumo do álcool, devendo estes aspectos serem considerados como norteadores na construção de intervenções na comunidade.
O uso da auriculoterapia no tratamento da dor
Authors: Freitas Adriano Luis , Nobrega Giovanna Costa , Barone Rayla Moura , Ribeiro Carolina Heitmann Mares Azevedo , Sousa Chriscia Jamilly Pinto de , Lo Prete Ana Cristina
Published: November 2024

Objetivo: Avaliar a eficácia da auriculoterapia para o tratamento da dor. Métodos: Este trabalho trata-se de uma revisão integrativa que avalia a eficácia da auriculoterapia no tratamento da dor e correlaciona essa técnica como alternativa ao uso de fármacos. A busca foi realizada por meio dos descritores em saúde “AURICULOTERAPIA” e “DOR”, nas línguas portuguesa, inglesa e espanhola, na base de dados, Medical Literature Analysis and Retrieval System on-line (PUBMED), uma vez que esta base permite buscas simultâneas nas principais fontes nacionais e internacionais. Resultados: Foram incluídos dezessete artigos científicos para a análise integrativa, sendo 16% avaliando a auriculoterapia em conjunto com outros métodos farmacológicos. Todos os artigos mostram o benefício da auriculoterapia na redução da dor, em especial durante o trabalho de parto (20%). Considerações Finais: Foi possível evidenciar que a auriculoterapia é uma boa alternativa não farmacológica para o tratamento de diversos tipos de dores, observada pelo sucesso na quantidade de estudos randomizados.
Atualizações no panorama do diabetes mellitus tipo 1
Authors: Tateno Juliana Jansem , Marinho Gabriella Ribeiro , Viana Marcos Vinícius Machado , Barroso Wermerson Assunção
Published: November 2024

Objetivo: Avaliar as principais atualizações sobre a influência do diabetes mellitus (DM1) na gravidez, doenças cardiovasculares e COVID-19, bem como a genética e o tratamento da doença. Revisão bibliográfica: O DM1 é uma condição autoimune complexa, marcada pela perda das células β pancreáticas, levando à insuficiência na produção de insulina. A sua incidência cresceu mundialmente desde os anos 1950, aumentando, nas últimas três décadas, entre 3% e 4%. O DM1 traz implicações significativas para condições como hipertensão, doença arterial periférica e coronariana, bem como seus portadores podem ter maior risco para complicações relacionadas à COVID-19. Mulheres grávidas com DM1 apresentam riscos obstétricos e neonatais adversos. O tratamento da doença envolve a administração de insulina e os avanços recentes têm focado em promover um melhor controle da glicemia e reduzir o risco de complicações. Considerações finais: O diagnóstico e tratamento precoce do DM1 reflete na morbimortalidade dos pacientes, pois evita complicações durante o desenvolvimento de outras doenças simultâneas e melhora a qualidade de vida das pessoas portadoras. É de suma importância que a equipe multidisciplinar se mantenha atualizada e na procura por inovações sobre a doença.