bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of Antecedent Precipitation Amount and COVID-19 Lockdown on Water Quality along an Urban Gradient
Authors: Ramirez Daniel , Chang Heejun , Gelsey Katherine
Published: December 2022

Water quality is affected by multiple spatial and temporal factors, including the surrounding land characteristics, human activities, and antecedent precipitation amounts. However, identifying the relationships between water quality and spatially and temporally varying environmental variables with a machine learning technique in a heterogeneous urban landscape has been understudied. We explore how seasonal and variable precipitation amounts and other small-scale landscape variables affect E. coli, total suspended solids (TSS), nitrogen-nitrate, orthophosphate, lead, and zinc concentrations in Portland, Oregon, USA. Mann–Whitney tests were used to detect differences in water quality between seasons and COVID-19 periods. Spearman’s rank correlation analysis was used to identify the relationship between water quality and explanatory variables. A Random Forest (RF) model was used to predict water quality using antecedent precipitation amounts and landscape variables as inputs. The performance of RF was compared with that of ordinary least squares (OLS). Mann–Whitney tests identified statistically significant differences in all pollutant concentrations (except TSS) between the wet and dry seasons. Nitrate was the only pollutant to display statistically significant reductions in median concentrations (from 1.5 mg/L to 1.04 mg/L) during the COVID-19 lockdown period, likely associated with reduced traffic volumes. Spearman’s correlation analysis identified the highest correlation coefficients between one-day precipitation amounts and E. coli, lead, zinc, and TSS concentrations. Road length is positively associated with E. coli and zinc. The Random Forest (RF) model best predicts orthophosphate concentrations (R2 = 0.58), followed by TSS (R2 = 0.54) and nitrate (R2 = 0.46). E. coli was the most difficult to model and had the highest RMSE, MAE, and MAPE values. Overall, the Random Forest model outperformed OLS, as evaluated by RMSE, MAE, MAPE, and R2. The Random Forest was an effective approach to modeling pollutant concentrations using both categorical seasonal and COVID data along with continuous rain and landscape variables to predict water quality in urban streams. Implementing optimization techniques can further improve the model’s performance and allow researchers to use a machine learning approach for water quality modeling.
Prevalence of Depression, Anxiety, and Stress among High School Students during the COVID-19 Pandemic: A Survey Study in Western Mexico
Authors: Cervantes-Cardona Guillermo Alonso , Cervantes-Guevara Gabino , Cervantes-Pérez Enrique , Fuentes-Orozco Clotilde , Barbosa-Camacho Francisco José , Chejfec-Ciociano Jonathan Matías , Brancaccio-Pérez Irma Valeria , Zarate-Casas María Fernanda , González-Ponce Fanny Yesenia , Ascencio-Díaz Kriscia Vanessa , Guzmán-Ruvalcaba Mario Jesús , Cueto-Valadez Tania Abigail , Cueto-Valadez Andrea Estefanía , González-Ojeda Alejandro
Published: December 2022

Social isolation and school closure may predispose adolescents to higher prevalence rates of depression, anxiety, and stress. In this cross-sectional observational study, the validated Spanish version of the Depression, Anxiety, and Stress Scale was administered to 3112 students aged 14–22 years old. We also collected data on participant gender, age group, school shift (morning or afternoon), school year, family type, whether they or any first-degree relative had been infected with COVID-19, whether any family member had died of COVID-19, and whether either of their parents worked. Mean scores were 8.34 ± 6.33 for depression, 7.75 ± 5.89 for anxiety, and 10.26 ± 5.84 for stress. Female students presented significantly higher scores on all three measures compared with male students. Students who had been infected with COVID-19, who had an infected family member, or who had a family member who died of COVID-19 also presented higher scores on all three measures. Identifying the symptoms and warning signs of depression and anxiety disorders is critical, particularly in vulnerable populations like adolescents.
Examining Learning Experience and Satisfaction of Accounting Students in Higher Education before and amid COVID-19
Authors: Shabeeb Mohamed A. , Sobaih Abu Elnasr E. , Elshaer Ibrahim A.
Published: December 2022

The widespread outbreak of the COVID-19 virus had substantial impacts on higher education, which turned into distance using virtual environments and electronic (e) learning platforms. There is a growing body of research on the effect of COVID-19 on students’ education and e-learning experiences amid the pandemic. However, limited research was performed to assess the learning experience before and amid the COVID-19 pandemic among students in specific disciplines such as accounting. The current research compares accounting students’ learning experience and satisfaction before and amid the COVID-19 pandemic. We distributed a pre-tested questionnaire online to students through our colleagues. The results of the SEM multi-group analysis with Amos indicated significant differences between students’ experience before and amid the COVID-19 pandemic, which had a significant influence on their satisfaction. Accounting students were found to have more participation in learning, to receive proper support and motivation, and to have better assessment and feedback before than amid COVID-19. However, they had better access to information and learning resources and were able to construct knowledge amid the pandemic using e-learning than before the pandemic. Several implications from the findings are raised and discussed.
The Associations of Communal Space with Sense of Place and Mental Health in Public Housing: Evidence from Guangzhou and Hong Kong
Authors: Zhang Tianyao , Liu Jiahui , Chen Huiwei , Ng Mee Kam
Published: December 2022

Communal space is regarded as essential for human well-being in high-rise developments in Asia and increasing attention has been given to the underlying mechanism of its effects in light of the ongoing COVID-19 pandemic. From the perspective of person–place processes, this paper explores ‘sense of place’ and its possible mediating effects on the relationship between communal space and the mental health of residents in high-rise public housing. An analysis of data from a questionnaire survey conducted in Hong Kong and Guangzhou revealed differentiated mechanisms according to local context and age group. Sense of place and its subcomponents mediated the connection between communal space and mental health in Hong Kong but not in Guangzhou. More specifically, place identity, place attachment and place dependence had stronger effects among older residents in HK than younger ones. The findings from this study can inform evidence-based planning and decision-making for public housing policy for health-oriented environments in high-density cities.
A Rapid Review Exploring the Role of Yoga in Healing Psychological Trauma
Authors: English Arabella , McKibben Elizabeth , Sivaramakrishnan Divya , Hart Niamh , Richards Justin , Kelly Paul
Published: December 2022

The evidence regarding the benefits of yoga for treating psychological trauma is well-established; however, there is a paucity of qualitative reviews exploring this topic. The purpose of this rapid review is to gain a deeper understanding of the impact that yoga can have on people with a history of psychological trauma and to reveal barriers and facilitators to the uptake of yoga in this cohort, from a qualitative perspective. The Ovid(EMBASE), Ovid(MEDLINE), PsycINFO, PubMed, and SPORTDiscus databases were searched using key terms. The systematic search generated 148 records, and 11 peer-reviewed articles met the inclusion criteria. The following main impacts of yoga on participants were identified: feeling an increased sense of self-compassion; feeling more centred; developing their coping skills; having a better mind–body relationship; and improving their relationships with others. The main barriers were also identified: concerns initiating yoga; time and motivational issues; and the costs and location of classes. The main facilitator was the feeling of safety generated in the trauma-informed yoga classes. This review suggests that yoga offers great potential in the field of trauma recovery. Despite this, more high-quality research with rigorous methodologies is called for to allow this field to advance.
Changes in the Enteric Neurons Containing Selected Active Substances in the Porcine Descending Colon after the Administration of Bisphenol A (BPA)
Authors: Makowska Krystyna , Gonkowski Sławomir
Published: December 2022

Bisphenol A (BPA) is an endocrine disruptor widely distributed in the environment due to its common use in the plastics industry. It is known that it has a strong negative effect on human and animal organisms, but a lot of aspects of this impact are still unexplored. This includes the impact of BPA on the enteric nervous system (ENS) in the large intestine. Therefore, the aim of the study was to investigate the influence of various doses of BPA on the neurons located in the descending colon of the domestic pig, which due to similarities in the organization of intestinal innervation to the human gastrointestinal tract is a good animal model to study processes occurring in human ENS. During this study, the double immunofluorescence technique was used. The obtained results have shown that BPA clearly affects the neurochemical characterization of the enteric neurons located in the descending colon. The administration of BPA caused an increase in the number of enteric neurons containing substance P (SP) and vasoactive intestinal polypeptide (VIP) with a simultaneously decrease in the number of neurons positive for galanin (GAL) and vesicular acetylcholine transporter (VAChT used as a marker of cholinergic neurons). Changes were noted in all types of the enteric plexuses, i.e., the myenteric plexus, outer submucous plexus and inner submucous plexus. The intensity of changes depended on the dose of BPA and the type of enteric plexus studied. The results have shown that BPA may affect the descending colon through the changes in neurochemical characterization of the enteric neurons located in this segment of the gastrointestinal tract.
Impacts of Urban Blue-Green Space on Residents’ Health: A Bibliometric Review
Authors: Wang Kun , Sun Zhihao , Cai Meng , Liu Lingbo , Wu Hao , Peng Zhenghong
Published: December 2022

Urban blue-green space (UBGS), as an important component of the urban environment, is found to closely relate to human health. An extensive understanding of the effects of UBGS on human health is necessary for urban planning and intervention schemes towards healthy city development. However, a comprehensive review and discussion of relevant studies using bibliometric methods is still lacking. This paper adopted the bibliometric method and knowledge graph visualization technology to analyze the research on the impact of UBGS on residents’ health, including the number of published papers, international influence, and network characteristics of keyword hotspots. The key findings include: (1) The number of articles published between 2001 and 2021 shows an increasing trend. Among the articles collected from WoS and CNKI, 38.74% and 32.65% of the articles focus on physical health, 38.32% and 30.61% on mental health, and 17.06% and 30.61% on public health, respectively. (2) From the analysis of international partnerships, countries with high levels of economic development and urbanization have closer cooperation than other countries. (3) UBGS has proven positive effects on residents’ physical, mental, and public health. However, the mediating effects of UBGS on health and the differences in the health effects of UBGS on different ages and social classes are less studied. Therefore, this study proposes several future research directions. First, the mediating effect of UBGS on health impacts should be further examined. Furthermore, the interactive effects of residents’ behaviors and the UBGS environment should be emphasized. Moreover, multidisciplinary integration should be strengthened. The coupling mechanism between human behavior and the environment should also be studied in depth with the help of social perception big data, wearable devices, and human–computer interactive simulation. Finally, this study calls for developing health risk monitoring and early warning systems, and integrating health impact assessment into urban planning, so as to improve residents’ health and urban sustainability.
Psychological and Behavioral Impacts of the COVID-19 Pandemic on Children and Adolescents in Turkey
Authors: Çoban Aysel Esen , Kaptan Nilay
Published: December 2022

The present study aimed to investigate the physical, psychological, and behavioral alteration in children in the age range between 3 and 18 years before and during the COVID-19 pandemic from the perspective of parental perception. In this study, the survey model was used as a quantitative research method. A snowball sampling method was used, and 841 mothers participated. Descriptive statistics, one-way analysis of variance, related samples t-test, Wilcoxon signed-rank test, and stepwise regression analysis were used to analyze the data. It was found that the physical, psychological, and behavioral negative impacts of the COVID-19 pandemic varied depending on the developmental stages of the children. Compared to the pre-pandemic period, an increase in children’s screen time, as well as a decrease in their physical activity time, was observed during the pandemic. In addition, it was found that screen time, physical activity time, and the square meters of the house are among the significant predictors of mood, behavioral changes, and nutritional problems in children. In terms of anxiety symptoms, physical activity time and screen time were found to be significant predictors. In addition, screen time, age, and physical activity time were observed to be significant predictors of cognitive change symptoms.
The Role of Attachment and Dyadic Coping in Shaping Relational Intimacy: Actor–Partner Interdependence Model
Authors: Wendołowska Anna , Czyżowska Natalia , Czyżowska Dorota
Published: December 2022

People’s attachment styles play a fundamental role in shaping their intimate relationships. Anxiously attached individuals have a strong need for closeness but a poor ability to obtain the closeness they seek. In contrast, people high in avoidance tend to avoid intimacy in close relationships. Dyadic coping can strengthen the bond between partners, and develop empathy, commitment, sensitivity, and responsiveness to the partner’s needs, which may be the basis of shaping intimacy and closeness. The effects of attachment on relational intimacy were examined, using the actor–partner interdependence model and data from 144 heterosexual couples, aged 26 to 60. Both partners completed measures of attachment, intimacy as a relationship satisfaction dimension, and dyadic coping. The results showed that men’s attachment-related avoidance is related to their own intimacy; also, the avoidant attachment of both spouses is related to each other’s intimacy. The effect of having children on intimacy was significant for men; the effect of financial situation on intimacy was significant for women. Moreover, problem-focused common dyadic coping appeared to have a significant moderating effect on the relationship between attachment-related avoidance and intimacy. Adult attachment and dyadic coping significantly contributed to partners’ relational intimacy.
Effects of Compression Stockings on Body Balance in Hemiplegic Patients with Subacute Stroke
Authors: Park Eo Jin
Published: December 2022

(1) Background: Stroke patients with hemiplegia have an increased risk of developing deep vein thrombosis (DVT). DVT increases the risk of life-threatening pulmonary embolism and is associated with poor prognosis. The early wearing of compression stockings can help prevent DVT. This study aimed to assess the impact of compression stockings on body balance in stroke patients with unilateral lower extremity muscle weakness; (2) Methods: Hemiplegic stroke patients in the subacute phase who were able to walk with assistance were recruited. The patients were divided into two groups: one group received rehabilitation treatment with compression stockings, and the other received treatment without compression stockings. The rehabilitation treatment involved hospitalization for 4 weeks, the Trunk Control Test (TCT), the Trunk Impairment Scale (TIS), and the Berg Balance Scale (BBS). The patients were evaluated before and 4 weeks after the start of treatment. The differences in BBS, TCT, and TIS before and after treatment between the two groups were compared; (3) Results: Altogether, 236 hemiplegic stroke patients were recruited. There was an improvement in body balance after treatment in both groups, and BBS, TCT, and TIS scores significantly increased in the group that received rehabilitation treatment with compression stockings; (4) Conclusions: In patients with hemiplegic stroke in the subacute period, rehabilitation while wearing compression stockings appears to improve body balance.
Smartphone Use Is Associated with Low Prevalence of Locomotive Syndrome among Elderly Individuals with Musculoskeletal Disorders
Authors: Miyashita Naoto , Ishida Tomohiro , Ikemoto Tatsunori , Hirasawa Atsuhiko , Arai Young-Chang , Deie Masataka
Published: December 2022

Objectives: Physical activity management through smartphone applications is increasing worldwide; however, it is unclear whether smartphone users among elderly Japanese individuals with musculoskeletal disorders are less likely to experience “locomotive syndrome” (LoS). We aimed to test the hypothesis that LoS in smartphone users had lower prevalence than that in non-smartphone users among elderly individuals with musculoskeletal disorders. Methods: Elderly participants, aged ≥60 years, who visited the outpatient clinic were enrolled. All participants were asked whether or not they used smartphones and were allocated into either the smartphone group or the non-smartphone group. After completing the 25-question Geriatric Locomotive Function Scale (GLFS-25), LoS prevalence was determined by 3-stage cutoff values of the GLFS-25 score (≥7, ≥16, and ≥24), and the total and three subdomain scores (body pain, movement-related difficulty, and psychosocial complications) were compared between the two groups. Generalized linear regression was then performed to confirm whether the use of smartphones was associated with lower GLFS-25 scores, even after controlling for confounders. Results: Overall, 266 participants, aged ≥60 years, were recruited. LoS prevalence was significantly higher in the non-smartphone group than in the smartphone group at all stages (all p < 0.001). Mean GLFS-25 total and subdomain scores were significantly lower in the smartphone group than in the non-smartphone group (all p < 0.001), and these statistical relationships were maintained even after controlling for age and sex. Conclusions: Smartphone use was associated with low LoS prevalence and low GLFS-25 scores among elderly individuals with musculoskeletal disorders, although the causal relationship remains unclear.
Evaluation of the Effect of SPIDER System Therapy on Weight Shifting Symmetry in Chronic Stroke Patients—A Randomized Controlled Trial
Authors: Ostrowska Paulina Magdalena , Studnicki Rafał , Rykaczewski Marcin , Spychała Dawid , Hansdorfer-Korzon Rita
Published: December 2022

(1) Background: The Strengthening Program for Intensive Developmental Exercises and Activities for Reaching Health Capability (SPIDER) system is dedicated to patients with motor deficits resulting from damage to the peripheral or central nervous system (including post-stroke patients). It enables the conduct of forced-weight-bearing therapy to the lower limb affected by the paresis. In this study, the TYMO® measuring platform was used to quantify the impact of therapy using the SPIDER system and therapy that did not use this system. The TYMO® device is a portable posturography platform that monitors the tilting of the body’s center of mass and reports the results of the rehabilitation process. (2) Objective: To evaluate the effect of therapy based on neurophysiological methods (proprioceptive neuromuscular facilitation (PNF), neurodevelopmental treatment according to the Bobath concept (NDT-Bobath)) and the SPIDER system on body weight transfer shifting, in post-stroke patients in the chronic phase, compared to therapy based on neurophysiological methods (PNF, NDT-Bobath), without the use of the SPIDER system. (3) Methods: This is a randomized controlled trial in which patients (n = 120; adults, post-ischemic stroke—first stroke episode, in chronic phase—up to 5 years after the stroke incident) were assigned to one of two groups: study, n = 60 (with therapy using PNF, NDT-Bobath methods and the SPIDER system); and control, n = 60 (with therapy using PNF and NDT-Bobath methods, without the SPIDER system). In patients in both groups, before and after the training (2 weeks of therapy), body weight distribution was measured on the TYMO® platform. (4) Results and Conclusions: The results of the statistical analysis demonstrated a greater reduction in the tilt of the body’s center of mass in therapy using the SPIDER system, compared to therapy in which the system was not used.
Nexus of Emotional Intelligence and Learning Outcomes: A Cross-Country Study of China and Pakistan Higher Educational Institutes
Authors: Shafait Zahid , Huang Jiayu
Published: December 2022

The purpose of this empirical study is to investigate the effects of emotional intelligence (EI) on learning outcomes (e.g., social, cognitive, and self-growth outcomes) and satisfaction with the university experience of academics and administrative staff at Chinese and Pakistani research universities. This study also investigates the mediation of self-directed learning (personal autonomy, personal responsibility, and personal growth) and knowledge management processes (KMPs) concerning the relationship between EI and learning outcomes. Moreover, this study explores the relationship between learning outcomes and creative performance (creative self-efficacy and leadership/supervisor support). The survey method was considered appropriate for the data collection and was completed simultaneously through paper and electronic mediums. The partial least squares structural equation modeling (PLS-SEM) method with a measurement assessment, structural assessment, mediation, and multi-group analysis was applied to a sample of 729 academics and administrative staff from Chinese and Pakistani research universities. A few dissimilarities surfaced with regard to EI and learning outcomes while evaluating the higher education institutions (HEIs) from both countries. Moreover, an indirect relation between EI and learning outcomes was established via self-directed learning and KMPs. Lastly, the intended direct statistical association between learning outcomes and creative performance was also documented. This study may serve as an initiative to equate and differentiate EI in relation to learning outcomes and creative performance among higher education professionals in China and Pakistan. The considered framework is novel and supports both EI and learning outcomes while adhering to the perceived value of the two adjacent regions.
Sexual Violence and Substance Use Diagnosed in Emergency Department Discharges in Hawaii, 2005–2014
Authors: Guo Mary , Do Bobby , Wong Korben , Lee Thomas , Talagi Deveraux , Lum Brandon , Rahberg Nichole , Ha Edra , Fan Victoria
Published: December 2022

Background: Substance use (SU) and sexual violence (SV) present unique challenges when contextualizing their relationship due to underreporting of SU and SV. Both are significant public health concerns with a large magnitude and expense to the overall U.S. and to the state of Hawaii, which is identified as a high-intensity drug-trafficking area. Since substance users have a higher risk for sexual violence than the general public, this study aims to analyze the proportion and demographics of emergency department (ED) visit individuals reporting sexual violence with or without substance use disorder and examine how the number of ED visits of individuals diagnosed with SV and SU disorder compare to all individuals. Methods: Data from the Healthcare Cost and Utilization Project was used to examine the relationship between SV and SU. The database contained 3.5 million observations for 24 Hawaii hospitals from 2005–2014. The data was summarized in descriptive statistics and Chi-square tests were run to assess statistical significance for variables of interest. Results: A greater proportion of individuals reporting sexual violence also reported substance use disorders compared to the general population of individuals. While 8% of all ED visits were related to SU, 17% of ED visits involving SV were also related to SU, demonstrating a statistically significant association between SV and SU. Conclusions: There is a greater need to further understand the complexity of the relationship between substance use and sexual violence. Sexual violence and substance use disorders share a complex relationship; survivors of sexual abuse may develop a substance use disorder, and those who use drugs and alcohol may be at an increased risk for sexual violence. Results from this study demonstrate visits for individuals reporting sexual violence have a greater proportion of substance use disorder than visits for the general population.
The Relationship between Mindfulness and Social Adaptation among Migrant Children in China: The Sequential Mediating Effect of Self-Esteem and Resilience
Authors: Wang Yue , Zheng Zexin , Duan Xiaoyi , Li Mengsha , Li Ying
Published: December 2022

Social adaptation of migrant children is not only related to the physical and mental health and development of individuals, but also reflects the level of urban social integration and stable development. Mindfulness has a protective effect on individual social adaptation. Self-esteem and resilience were found to be positively associated with mindfulness and social adaptation. Based on the Positive Youth Development Perspective, this study aimed to explore whether self-esteem and resilience sequentially mediated the associations among mindfulness and social adaptation. A total of 526 migrant children were assessed with the questionnaires regarding mindfulness, self-esteem, resilience, and social adaptation. The results indicated that mindfulness was positively associated with social adaptation of migrant children. Self-esteem and resilience played the sequential mediating roles between mindfulness and social adaptation. The present study revealed the influence and mechanism of mindfulness on social adaptation and provided some guidance for the intervention programs to promote migrant children’s adaptability.
Factors Associated with Unwanted Sexual Attention in Australian Nightlife Districts: An Exploratory Study of Nightlife Attendees
Authors: Baldwin Ryan , Dhinsa Tavleen , de Andrade Dominique , Coomber Kerri , Curtis Ashlee , Wells Samantha , Ferris Jason , Puljevic Cheneal , Hyder Shannon , Litherland Steven , Miller Peter
Published: December 2022

Background: Experiences of unwanted sexual attention (UWSA) are commonplace within nightlife environments. While typically associated with aggression perpetration, literature has suggested that a history of childhood corporal punishment (CCP) may also be related to experiences of victimisation in nightlife environments. The current exploratory study aims to examine the associations between experiences of UWSA victimisation and a history of CCP, trait aggression, and conformity to masculine norms (Playboy and Winning), for males and females separately. Method: Street intercept interviews in the Brisbane inner-city entertainment precincts were used to measure demographic details and participants’ breath alcohol concentration. Online follow-up surveys were used to record participants’ experiences of UWSA on the night of interview, history of CCP, and self-reported rates of trait aggression and conformity to masculine norms. The final sample consisted of 288 females, as there were not sufficient male UWSA experiences for analysis. Results: Approximately 20% of female nightlife patrons experienced some form of UWSA victimisation. Logistic regression analyses identified that after controlling for age and intoxication, a history of CCP, trait aggression and masculine norm conformity were unrelated to experiences of UWSA for female respondents. Conclusions: The current study found that individual factors were unrelated to experiences of UWSA, indicating that simply being in the nightlife environment, especially as a female, increases the risk of UWSA victimisation. Understanding and exploring social and environmental risk factors, rather than individual factors, is needed to prevent victimisation in nightlife environments.
Cardiorespiratory Fitness, Obesity and Physical Activity in Schoolchildren: The Effect of Mediation
Authors: González-Gálvez Noelia , Ribeiro Jose Carlos , Mota Jorge
Published: December 2022

There are only a few studies that have examined the interaction between physical activity (PA), cardiorespiratory fitness (CRF), and overweightness/obesity in adolescents, and these studies have shown some limitations. The objective of this study was to examine whether the association between PA (moderate–vigorous PA [MVPA], moderate PA [MPA], and vigorous PA [VPA]) and obesity is mediated by CRF. This cross-sectional study was conducted in six middle and high-schools in the Porto district (Portugal), comprising 632 children and adolescents. Fat mass (FM), CRF, MVPA, MPA, and VPA were assessed. The Process macro for SPSS was used. CRF was significantly associated with PA for both children and adolescents. Likewise, FM was negatively and significantly associated with CRF for both children (β = −0.337) and adolescents (β = −0.255). FM was associated with PA in children (MVPA: β = −0.102; MPA: β = −0.118; VPA: β = −0.305) and adolescents (MVPA: β: −0.103; MPA: β = −0.082; VPA: β = −0.204). The mediation analysis showed that the association between PA (MVPA//MPA/VPA) and obesity was mediated by CRF, in both children and adolescents, with a significant value in the Sobel test. Obesity is associated with CRF and MVPA, MPA, and VPA. However, CRF acted as a complete mediator between the association of obesity and PA.
Influences of Emotional Information on Response Inhibition in Gaming Disorder: Behavioral and ERP Evidence from Go/Nogo Task
Authors: Chen Yuzhou , Yu Hongling , Gao Xuemei
Published: December 2022

Background: Gaming disorder (GD) may impair executive functions such as response inhibition. According to the tripartite neurocognitive model, the interoceptive system generates a state of craving that exacerbates the dysfunction of GD. We speculate that emotional information may play an important role in the mechanism, which leads to impaired response inhibition in people with GD. Methods: A three-factor mixed experimental design was adopted in this go/nogo task. The between-subject factor was group (GD or control group), and the within-subject factors were two types of emotional information, task relevance (related or unrelated) and emotional valence (negative or positive). Results: The GD group had lower nogo accuracies than the control group in the task-unrelated condition and also in the negative condition. Parallelly, the GD group showed faster reactions and lower accuracy in the go trials than the control group under task-unrelated negative conditions. At the neural level, the GD group had smaller amplitudes of nogo-N2 and larger amplitudes of nogo-P3 than the control group in the task-unrelated condition. Conclusions: The findings prove the hypothesis of this study that emotional information could be a factor leading to impaired response inhibition in GD individuals. The response inhibition abilities of GD are weakened when processing task-unrelated or negative information, which may be caused by failure of behavioral inhibition and weakened conflict control, resulting in more cognitive resources to complete response suppression under specific conditions. This study provides evidence for weaker response inhibition in GD individuals from the perspective of cognitive–emotional interaction and provides more detailed information for interventions for GD.
Correlation between Component Factors of Non-Alcoholic Fatty Liver Disease and Metabolic Syndrome in Nurses: An Observational and Cross-Sectional Study
Authors: Chang Wen-Pei , Chang Yu-Pei
Published: December 2022

This study aimed to understand the correlation between non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome in nurses. Questionnaires were used to eliminate individuals with a daily drinking habit, hepatitis B or C, or incomplete data. A total of 706 valid samples were obtained. The prevalence of NAFLD among nurses was 36.8%. Nurses with a greater age (OR = 1.08, 95% CI: 1.01–1.16), obese BMI (OR = 23.30, 95% CI: 8.88–61.10), overweight BMI (OR = 3.89, 95% CI: 2.15–7.04), waist circumference exceeding the standard (OR = 2.10, 95% CI: 1.14–3.87), fasting blood glucose 100–125 mg/dL (OR = 4.09, 95% CI: 1.19–14.03), and overly low HDL-C (OR = 2.01, 95% CI: 1.05–3.85) were at greater risk of NAFLD. Furthermore, male nurses (OR = 6.42, 95% CI: 1.07–38.70), nurses with triglycerides over 150 mg/dL (OR = 4.80; 95% CI: 1.05–21.95), and nurses with HDL-C lower than the standard (OR = 5.63, 95% CI: 1.35–23.49) were at greater risk of moderate/severe NAFLD. Among younger nurses, those of greater age, male nurses, obese and overweight nurses, and those with a waist circumference exceeding the standard, 100–125 mg/dL, overly low HDL-C, and triglycerides over 150 mg/dL should consider the possibility that they have NAFLD.
Bismuth-Decorated Beta Zeolites Catalysts for Highly Selective Catalytic Oxidation of Cellulose to Biomass-Derived Glycolic Acid
Authors: Wang Fenfen , Qu Dongxue , Wang Shaoshuai , Liu Guojun , Zhao Qiang , Hu Jiaxue , Dong Wendi , Huang Yong , Xu Jinjia , Chen Yuhui
Published: December 2022

Catalytic conversion of cellulose to liquid fuel and highly valuable platform chemicals remains a critical and challenging process. Here, bismuth-decorated β zeolite catalysts (Bi/β) were exploited for highly efficient hydrolysis and selective oxidation of cellulose to biomass-derived glycolic acid in an O2 atmosphere, which exhibited an exceptionally catalytic activity and high selectivity as well as excellent reusability. It was interestingly found that as high as 75.6% yield of glycolic acid over 2.3 wt% Bi/β was achieved from cellulose at 180 °C for 16 h, which was superior to previously reported catalysts. Experimental results combined with characterization revealed that the synergetic effect between oxidation active sites from Bi species and surface acidity on H-β together with appropriate total surface acidity significantly facilitated the chemoselectivity towards the production of glycolic acid in the direct, one-pot conversion of cellulose. This study will shed light on rationally designing Bi-based heterogeneous catalysts for sustainably generating glycolic acid from renewable biomass resources in the future.
Inhibitory Effects of Nobiletin on Voltage-Gated Na+ Channel in Rat Ventricular Myocytes Based on Electrophysiological Analysis and Molecular Docking Method
Authors: Gu Youwei , Wang Jieru , Li Mengting , Zhong Fei , Xiang Jie , Xu Zhengxin
Published: December 2022

Nobiletin (NOB) has attracted much attention owing to its outstanding bioactivities. This study aimed to investigate its anti-arrhythmic effect through electrophysiological and molecular docking studies. We assessed the anti-arrhythmic effects of NOB using aconitine-induced ventricular arrhythmia in a rat model and the electrophysiological effects of NOB on rat cardiomyocytes utilizing whole-cell patch-clamp techniques. Moreover, we investigated the binding characters of NOB with rNav1.5, rNav1.5/QQQ, and hNaV1.5 via docking analysis, comparing them with amiodarone and aconitine. NOB pretreatment delayed susceptibility to ventricular premature and ventricular tachycardia and decreased the incidence of fatal ventricular fibrillation. Whole-cell patch-clamp assays demonstrated that the peak current density of the voltage-gated Na+ channel current was reversibly reduced by NOB in a concentration-dependent manner. The steady-state activation and recovery curves were shifted in the positive direction along the voltage axis, and the steady-state inactivation curve was shifted in the negative direction along the voltage axis, as shown by gating kinetics. The molecular docking study showed NOB formed a π-π stacking interaction with rNav1.5 and rNav1.5/QQQ upon Phe-1762, which is the homolog to Phe-1760 in hNaV1.5 and plays an important role in antiarrhythmic action This study reveals that NOB may act as a class I sodium channel anti-arrhythmia agent.
Direct In Vivo Comparison of 99mTc-Labeled Scaffold Proteins, DARPin G3 and ADAPT6, for Visualization of HER2 Expression and Monitoring of Early Response for Trastuzumab Therapy
Authors: Tolmachev Vladimir , Bodenko Vitalina , Oroujeni Maryam , Deyev Sergey , Konovalova Elena , Schulga Alexey , Lindbo Sarah , Hober Sophia , Bragina Olga , Orlova Anna , Vorobyeva Anzhelika
Published: December 2022

Non-invasive radionuclide molecular visualization of human epidermal growth factor receptor type 2 (HER2) can provide stratification of patients for HER2-targeting therapy. This method can also enable monitoring of the response to such therapies, thereby making treatment personalized and more efficient. Clinical evaluation in a phase I study demonstrated that injections of two scaffold protein-based imaging probes, [99mTc]Tc-(HE)3-G3 and [99mTc]Tc-ADAPT6, are safe, well-tolerated and cause a low level of radioactivity in healthy tissue. The goal of this preclinical study was to select the best probe for stratification of patients and response monitoring. Biodistribution of both tracers was compared in mice bearing SKOV-3 xenografts with high HER2 expression or MDA-MB-468 xenografts with very low expression. Changes in accumulation of the probes in SKOV-3 tumors 24 h after injection of trastuzumab were evaluated. Both [99mTc]Tc-ADAPT6 and [99mTc]Tc-(HE)3-G3 permitted high contrast imaging of HER2-expressing tumors and a clear discrimination between tumors with high and low HER2 expression. However, [99mTc]Tc-ADAPT6 has better preconditions for higher sensitivity and specificity of stratification. On the other hand, [99mTc]Tc-(HE)3-G3 is capable of detecting the decrease of HER2 expression on response to trastuzumab therapy only 24 h after injection of the loading dose. This indicates that the [99mTc]Tc-(HE)3-G3 tracer would be better for monitoring early response to such treatment. The results of this study should be considered in planning of further clinical development of HER2 imaging probes.
Integral Algorithms to Evaluate TiO2 and N-TiO2 Thin Films’ Cytocompatibility
Authors: Zhuravleva Irina Yu. , Surovtseva Maria A. , Alshevskaya Alina A. , Surovtsev Nikolay V. , Okotrub Konstantin A. , Kim Irina I. , Nasimov Dmitriy A. , Bondarenko Natalia A. , Kuzmin Oleg S. , Poveshchenko Olga V.
Published: December 2022

Titanium oxide (TiO2) and oxynitride (N-TiO2) coatings can increase nitinol stents’ cytocompatibility with endothelial cells. Methods of TiO2 and N-TiO2 sputtering and cytocompatibility assessments vary significantly among different research groups, making it difficult to compare results. The aim of this work was to develop an integral cytocompatibility index (ICI) and a decision tree algorithm (DTA) using the “EA.hy926 cell/TiO2 or N-TiO2 coating” model and to determine the optimal cytocompatible coating. Magnetron sputtering was performed in a reaction gas medium with various N2:O2 ratios and bias voltages. The samples’ morphology was studied by scanning electron microscopy (SEM) and Raman spectroscopy. The cytocompatibility of the coatings was evaluated in terms of their cytotoxicity, adhesion, viability, and NO production. The ICI and DTA were developed to assess the cytocompatibility of the samples. Both algorithms demonstrated the best cytocompatibility for the sample sputtered at Ubias = 0 V and a gas ratio of N2:O2 = 2:1, in which the rutile phase dominated. The DTA provided more detailed information about the cytocompatibility, which depended on the sputtering mode, surface morphology, and crystalline phase. The proposed mathematical models relate the cytocompatibility and the studied physical characteristics.
Endoplasmic Reticulum Stress Signaling and Neuronal Cell Death
Authors: Merighi Adalberto , Lossi Laura
Published: December 2022

Besides protein processing, the endoplasmic reticulum (ER) has several other functions such as lipid synthesis, the transfer of molecules to other cellular compartments, and the regulation of Ca2+ homeostasis. Before leaving the organelle, proteins must be folded and post-translationally modified. Protein folding and revision require molecular chaperones and a favorable ER environment. When in stressful situations, ER luminal conditions or chaperone capacity are altered, and the cell activates signaling cascades to restore a favorable folding environment triggering the so-called unfolded protein response (UPR) that can lead to autophagy to preserve cell integrity. However, when the UPR is disrupted or insufficient, cell death occurs. This review examines the links between UPR signaling, cell-protective responses, and death following ER stress with a particular focus on those mechanisms that operate in neurons.
Association between 25-OH Vitamin D Deficiency and COVID-19 Severity in Pregnant Women
Authors: Vásquez-Procopio Johana , Torres-Torres Johnatan , Borboa-Olivares Hector , Sosa Salvador Espino Y , Martínez-Portilla Raigam Jafet , Solis-Paredes Mario , Tolentino-Dolores Mari-Cruz , Helguera-Repetto Addy Cecilia , Marrufo-Gallegos Karla Cecilia , Missirlis Fanis , Perichart-Perera Otilia , Estrada-Gutierrez Guadalupe
Published: December 2022

Evidence from studies in the general population suggests an association between vitamin D insufficiency/deficiency and COVID-19 susceptibility and disease severity. The present study was performed on 165 third-trimester pregnant women at the time of delivery. Seventy-nine women tested negative for SARS-CoV-2. From 86 women testing positive, 32 were asymptomatic, 44 presented a mild form of the disease, and 10 experienced severe symptoms. Serum 25-OH vitamin D levels were measured on blood samples collected on admission. Low vitamin D levels were detected in symptomatic but not asymptomatic COVID-19 patients compared to healthy women (p = 0.0227). In addition, 20 (45.4%) pregnant women in the mild COVID-19 group and 6 (60%) in the severe group were vitamin D deficient (p = 0.030). On the other hand, lasso regression analysis showed that 25-OH vitamin D deficiency is an independent predictor of severe COVID-19 with an odds ratio (OR) of 5.81 (95% CI: 1.108–30.541; p = 0.037). These results show the relationship between vitamin D deficiency in pregnant women and the severity of COVID-19 infection and support the recommendation to supplement with vitamin D to avoid worse COVID-19 outcomes during pregnancy.
One-Step Pyrolysis of Nitrogen-Containing Chemicals and Biochar Derived from Walnut Shells to Absorb Polycyclic Aromatic Hydrocarbons (PAHs)
Authors: Wang Wendong , Li Donghua , Xiang Ping , Zheng Yunwu , Zheng Zhifeng , Lin Xu , He Xiahong , Liu Can
Published: December 2022

The pyrolysis of biomass is an efficient means of utilizing biomass resources. Biomass can be converted into various high-performance chemicals and functional materials through pyrolysis. However, current pyrolysis technologies suffer from low conversion rates and single products, so the preparation of nitrogen compounds with high economic value remains a challenge. The walnut shell was soaked in three nitrogen-containing compound solutions before carbonization to produce high-value-added nitrogen-containing chemicals (with a nitrogen content of 59.09%) and biochar for the adsorption of polycyclic aromatic hydrocarbons (PAHs). According to biochar analysis, biochar has a porous structure with a specific surface area of 1161.30 m2/g and a high level of rocky desertification. The surface forms a dense pyrrole structure, and the structure produces π–π interactions with naphthalene molecules, exhibiting excellent naphthalene adsorption with a maximum capacity of 214.98 mg/g. This study provides an efficient, rapid, and environmentally friendly method for producing nitrogen-containing chemicals with high-added value and biochar.
Mulberry Leaf Supplements Effecting Anti-Inflammatory Genes and Improving Obesity in Elderly Overweight Dogs
Authors: Park Miey , Jaiswal Varun , Kim Kihyun , Chun Julan , Lee Mi-Jin , Shin Jae-Ho , Lee Hae-Jeung
Published: December 2022

Overweight and obesity, associated with various health complications, refer to abnormal or excessive fat accumulation conditions that harm health. Like humans, obesity is a growing problem in dogs, which may increase the risk of serious diseases such as diabetes and cancer. Mulberry leaf has shown potential anti-obesity and anti-diabetes effects in several studies. Our research studied the impact of mulberry leaf supplements in healthy old overweight dogs for 12 weeks. Blood and fecal samples were collected from the dogs before and after treatment for different analyses, including whole transcriptome and gut microbiome analysis. The Body Condition Score (BCS) and blood glucose levels were significantly decreased in all mulberry treatment groups, which justifies the anti-obesity effect of mulberry leaf in dogs. Throughout the whole transcriptome study, the downregulation of PTX3 and upregulation of PDCD-1, TNFRSF1B, RUNX3, and TICAM1 genes in the high mulberry group were found, which have been associated with anti-inflammatory effects in the literature. It may be an essential gene expression mechanism responsible for the anti-inflammatory and, subsequently, anti-obesity effects associated with mulberry leaf treatment, as confirmed by real-time polymerase chain reaction analysis. In microbiome analysis, Papillibacter cinnamivorans, related to the Mediterranean diet, which may cause anti-inflammatory effects, were abundant in the same treatment group. Further studies may be required to establish the gene expression mechanism and role of abundant bacteria in the anti-obesity effect of mulberry supplements in dogs. Overall, we propose mulberry leaves as a portion of food supplements for improving blood glucose levels and the anti-inflammation of blood in companion dogs.
Enhanced Exciton Effect and Singlet Oxygen Generation Triggered by Tunable Oxygen Vacancies on Bi2MoO6 for Efficient Photocatalytic Degradation of Sodium Pentachlorophenol
Authors: Xu Xiao , Yang Xianglong , Tao Yunlong , Zhu Wen , Ding Xing , Zhu Junjiang , Chen Hao
Published: December 2022

Construction of the tunable oxygen vacancies (OVs) is widely utilized to accelerate molecular oxygen activation for boosting photocatalytic performance. Herein, the in-situ introduction of OVs on Bi2MoO6 was accomplished using a calcination treatment in an H2/Ar atmosphere. The introduced OVs can not only facilitate carrier separation, but also strengthen the exciton effect, which accelerates singlet oxygen generation through the energy transfer process. Superior carrier separation and abundant singlet oxygen played a crucial role in favoring photocatalytic NaPCP degradation. The optimal BMO-001-300 sample exhibited the fastest NaPCP degradation rate of 0.033 min−1, about 3.8 times higher than that of the pristine Bi2MoO6. NaPCP was effectively degraded and mineralized mainly through dechlorination, dehydroxylation and benzene ring opening. The present work will shed light on the construction and roles of OVs in semiconductor-based photocatalysis and provide a novel insight into ROS-mediated photocatalytic degradation.