bluuebunny/crossref_metadata_2025 huggingface dataset:
Stability of Fe5O6 and its relation to other Fe-Mg-oxides at high pressures and temperatures
Authors: Woodland Alan B. , Uenver-Thiele Laura , Ballaran Tiziana Boffa , Miyajima Nobuyoshi , Rosbach Kevin , Ishii Takayuki
Published: February 2022

The stability of Fe5O6 has been experimentally determined under pressure-temperature conditions relevant for the Earth’s deeper upper mantle down to the upper portion of the lower mantle (to 28 GPa). In addition, we investigated the incorporation of Mg into Fe5O6 and its systematics, which allows us to discuss the relevance of this phase for the mantle. Experiments were performed from 8–28 GPa and 900–1600 °C. Additional oxide phases may appear if the bulk composition does not maintain the Fe32+Fe23+O6 stoichiometry during the experiment, including coexisting Fe4O5 or Fe9O11. Unfortunately, the similarities in Raman spectra between several high-pressure Fe-oxide phases make this method unsuitable for distinguishing which phase is present in a given sample. The stability field for Fe5O6 extends from ~9 to at least 28 GPa but is truncated at lower temperatures by the assemblage Fe4O5 + wüstite. Refined thermodynamic properties for Fe5O6 are presented. The range of redox stability of Fe5O6 appears to be more limited than that of Fe4O5.

Solid solution along the Fe5O6-Mg3Fe2O6 binary is quite limited, reaching a maximum Mg content of ~0.82 cations per formula unit (i.e., XMg3Fe2O6 ≈ 0.27) at 1400 °C and 10 GPa. The observed sharp decrease in molar volume of the O6-phase with Mg content could be a possible explanation for the limited range of solid solution. A phase diagram has been constructed for a composition of approximately Mg0.5Fe2.52+Fe23+O6 stoichiometry. This small amount of Mg causes a significant change in the relations between the O6-structured phase and the assemblage O5-structured phase + (Mg,Fe)O. Several experiments were performed to test whether the O6-phase can coexist with mantle silicates like wadsleyite and ringwoodite. In all cases, the run products contained (Mg,Fe)2Fe2O5 rather than the O6-phase, further underlining the limited ability of Fe5O6 to accommodate enough Mg to be stable in a mantle assemblage.

The large stability field of Fe5O6 implies that this phase could likely occur in locally Fe-rich environments, like those sampled by some “deep” diamonds. However, the limited solubility of Mg in the O6-phase leads us to conclude that the O5-phase should be of much more relevance as an accessory phase in a peridotitic mantle assemblage.
Jingwenite-(Y) from the Yushui Cu deposit, South China: The first occurrence of a V-HREE-bearing silicate mineral
Authors: Liu Peng , Gu Xiangping , Zhang Wenlan , Hu Huan , Chen Xiaodan , Wang Xiaolin , Song Wenlei , Yu Miao , Cook Nigel J.
Published: February 2022

Jingwenite-(Y), Y2Al2V24+(SiO4)O4(OH)4, the first V-HREE-bearing silicate mineral discovered in nature, is an abundant component of a sediment-hosted stratiform Cu (SSC) deposit, Yushui, South China. The mineral occurs in bedded/massive sulfide-bearing ore and is associated with bornite, chalcopyrite, galena, xenotime-(Y), nolanite, thortveitite, roscoelite, barite, and quartz. Optically, jingwenite-(Y) is biaxial (+), with α = 1.92(4), β = 1.95(2), γ = 1.99(3) (white light), and 2V (calculated) = 83°. The dispersion is medium with r < v, and the pleochroism is with X = light brown, Y = brown, Z = dark brown. The color, streak, luster, and hardness (Mohs) are light brown, yellowish gray, vitreous, and 4½–5, respectively.

Jingwenite-(Y) is monoclinic, with space group I2/a, Z = 4, and unit-cell parameters a = 9.4821(2) Å, b = 5.8781(1) Å, c = 19.3987(4) Å, β = 90.165(2)°, and V = 1081.21(4) Å3. The structure of jingwenite-(Y) has chains of edge-sharing Al(V,Fe)-O octahedra and V(Ti)-O octahedra extending along the b-axis and linked by insular Si-O tetrahedra, leaving open channels occupied by HREEs. Jingwenite-(Y) is a new nesosilicate structural type.

Sm-Nd dating and Nd isotope signatures of jingwenite-(Y) reveal an epigenetic origin and suggest that HREEs and V were added to the SSC system via leaching of abundant heavy minerals in the footwall red sandstone by oxidized basinal brines. The abundance of jingwenite-(Y) at Yushui indicates that it could potentially be a valuable resource for HREE and V. Moreover, HREE and V mineralization can also occur in the same sediment-hosted Cu mineral system.
Saatnya Mempraktikan Desain Bermatra Sosial
Authors: Suastiwi Triatmodjo
Published: February 2022

Situasi pandemi covid-19 belum diketahui kapan akan berakhir, saat ini ia menjadi permasalahan yang luar biasa berat bagi kehidupan umat manusia di dunia. Dan selain pademi covid-19 masih banyak permasalahan lain yang perlu diperhatikan oleh kita semua seperti kerusakan lingkungan, revolusi industri 4.0 dan AI-nya, masalah pendidikan serta problem kesehatan masyarakat pada umumnya. Apa yang tersebut di atas tampaknya bukan permasalahan sederhana, tetapi permasalahan yang kompleks dan mengandung banyak aspek (perilaku, sosial dan budaya). Seorang Viktor Margolin pernah mengatakan bahwa untuk saat ini model sosial desain lebih dibutuhkan dari pada desain “produk” pada umumnya. Makalah ini membahas, salah satu pendekatan desain bermatra sosial yaitu desain transformatif (transformative design) dan kemudian menyandingkannya dengan salah satu kasus inovasi sosial yang hadir di kota Yogyakarta, Bendungan Lepen Gajah Wong. Pada masa sekarang permasalahan desain yang dihadapi masyarakat Indonesia semakin kompleks dan multi aspek, dari pembahasan dapat disimpulkan bahwa desain bermatra sosial dapat menjadi salah satu metode untuk mengatasinya.
Perancangan Iklan Layanan Masyarakat “Mencuci Tangan” Sebagai Upaya Tanggap Covid-19
Authors: Nisa Laili Nursya'baana  , Nova Kristiana  , Asidigisianti Surya Patria
Published: February 2022

Di tempat-tempat usaha, seperti toko kelontong, toko beras, ataupun warung makan yang dimiliki oleh masyarakat umum harus menyediakan tempat mencuci tangan sebagai salah satu protokol WHO untuk pencegahan COVID-19. Tempat-tempat mencuci tangan bermunculan di depan toko atau tempat-tempat umum bersifat sementara. Biasanya terbuat dari ember atau tempat air yang diberi keran. Di tempat-tempat air tersebut tidak diberi arahan bagaimana mencuci tangan yang benar. Masyarakat sering mencuci tangan tidak sesuai dengan tata cara cuci tangan yang benar. Tujuan perancangan ini adalah merancang stiker Iklan Layanan Masyarakat (ILM) tentang Mencuci Tangan. Proses perancangan suatu karya desain grafis yaitu stiker memerlukan data yang akurat untuk dianalisis dalam mendukung konsep yang melandasi pembuatan karya. Sumber data primer atau utama diperoleh dari pengamatan/observasi cara mencuci tangan yang betul, baik dari video, pengamatan langsung dan dari selebaran (flyer) yang dikeluarkan oleh Kementerian Kesehatan. Sumber data sekunder adalah data yang tidak langsung memberikan data pengumpul data melalui. Data ini didapat dari studi literatur, baik diperoleh dalam buku maupun artikel dan foto-foto yang diperoleh berdasarkan hubungan dengan objek perancangan. Informasi diperoleh dari beberapa buku atau artikel yang mencangkup informasi mengenai cara mencuci tangan yang benar. Agar ILM dapat tepat sasaran dan berhasil mencapai tujuan maka perlu mempertimbangkan aspek audien.    Tahap perancangan dimulai dengan menggambarkan sebuah konsep yang diperoleh dari berbagai informasi berkaitan dengan urutan mencuci tangan yang benar dalam sebuah thumbnail dan thigttisue. Hasil perancangan ini adalah stiker ILM Mencuci Tangan yang digunakan untuk kampanye sosial bagaimana mencuci tangan yang benar.  Stiker ditempel di ember berkeran untuk mencuci tangan.
Perancangan Sarana Penyimpanan Dokumen Penting Untuk Mengantisipasi Dampak Bencana Banjir
Authors: Mami Utami  , Mohamad Arif Waskito
Published: February 2022

Banyak kota di Indonesia yang rentan terhadap banjir, terutama kota – kota yang berada di daerah aliran sungai (DAS), bantaran kali dan daerah muara – muara sungai. Terjadinya banjir disebabkan beberapa faktor diantaranya pendangkalan atau sedimentasi, pemanfaatan DAS menjadi area hunian dan curah hujan yang tinggi. Pada saat banjir, manusia akan mengalami kepanikan, karena dalam kondisi tertekan dan dalam waktu yang terbatas mereka harus berupaya untuk menyelamatkan jiwa, barang dan dokumen berharganya. Menyelamatkan dokumen – dokumen penting atau berharga seperti sertifikat tanah, ijazah, buku nikah dan lainnya menjadi sangat penting untuk diperhatikan sehingga diperlukan perangkat atau alat simpan dokumen yang tidak hanya dapat melindungi dokumen dari air, tapi juga bisa dengan cepat diraih, ditemukan dalam gelap dan dibawa pada saat terburu – buru. Proses perancangan produk penyimpan dokumen penting ini dilakukan melalui kegiatan pengkajian dengan tahapan – tahapan Emphatize, Define, Idea, Prototype, dan Test, seperti yang biasa dilakukan di metode Design Thinking pada umumnya. Produk sarana penyimpanan dokumen ini memiliki desain yang sangat mempertimbangkan faktor fungsi, material, dan operasional. Kriteria yang ditetapkan dan diimplementasikan pada desain produk ini diharapkan dapat efektif melindungi dokumen – dokumen penting dari kerusakan atau kehilangan pada saat terjadi banjir khususnya yang sering dialami oleh masyarakat yang tinggal di wilayah – wilayah rawan banjir.
Perancangan Keyboard Mekanik Sinar Ultraviolet-c untuk Mencegah penyebaran Bakteri dan Virus Di Warung Internet
Authors: Muhammad Ayub Teguh Prakoso  , Dr. Rahmawan Dwi Prasetya  , Sekartaji Suminto
Published: February 2022

Keyboard adalah perangkat yang keberadaannya sangat penting pada era modern sebagai alat yang berfungsi untuk memasukkan data berupa hussus lain huruf, angka dan perintahnya yang nantinya akan diproses oleh komputer. Menurut WHO tangan merupakan jalur utama penularan kuman dan keyboard merupakan perangkat komputer yang berkontak langsung dengan tangan manusia. Kebersihan permukaan keyboard belum tertentu terjaga dengan baik terlebih pada Fasilitas keyboard yang berada pada tempat umum seperti warnet(warung internet) yang di mana digunakan lebih dari satu pengguna. Bakteri dan virus yang menempel di permukaan keyboard dari pengguna sebelumnya sangat berbahaya bagi pengguna berikutnya, bakteri dan virus yang terdapat pada permukaan keyboard dapat  memicu penyebaran penyakit melalui permukaan keyboard yang tidak bersih. Atas dasar adanya penularan bakteri dan virus serta bakteri dan virus yang dapat berkembang biak pada permukaan keyboard pada perancangan keyboard mekanik dengan sinar ultraviolet-c dapat mencegah penyebaran dan perkembangbiakan bakteri dan virus yang ada pada permukaan keyboard.
Implementasi Prototyping Produk Fleksible dengan Mesin CNC Multifungsi (milling, laser co2 dan 3d printing)
Authors: Harki Apri Yanto  , Heru Suprapto  , Antonius Kristijono  , Febri Setianto
Published: February 2022

Pandemi Coronavirus 2019 menyebabkan terjadinya perubahan tatanan dalam kehidupan bermasyarakat dengan adanya pengaturan jarak fisik (physical distancing), sehingga terjadi efek domino tidak hanya dalam kehidupan bermasyarakat, tetapi juga berpengaruh dalam pola rantai suplai produk dan jasa. Selain itu digabungkannya semangat entrepreneurship untuk mencetak wirausaha baru dan penciptaan lapangan pekerjaan baru pada generasi muda, memungkinkan lulusan perguruan tinggi banyak yang mencoba berwirausaha dengan mengembangkan produk hasil penelitian selama di kuliah, meski dengan kemampuan dan pengetahuan manufaktur, serta kemampuan finansial yang terbatas. Fenomena ini menyebabkan, banyak sekali proses pengembangan produk berbasis kriya komersial terpaksa mengalami hambatan yang disebabkan antara lain: ketergantungan dengan komponen impor, keterbatasan mesin produksi buatan lokal yang mampu menghasilkan kualitas produk dengan harga ekonomis. Hal ini yang mendasari pengembangan 1 unit mesin cnc dengan kemampuan proses milling, pemotongan laser, dan fungsi cetak 3d berbasis FDM (fused deposition modelling), sehingga desainer produk mampu mengembangkan prototipe produk dengan pengetahuan dan kemampuan manufaktur terbatas, dengan 3 kemampuan proses manufaktur sekaligus. Proses pengembangan telah dimulai dari 2018, dengan mengembangkan meja Mesin CNC yang mampu beradaptasi dengan proses milling, proses pemotongan laser CO2, dan proses cetak 3d printing, pengembangan sistem controller yang memfasilitasi ke 3 fungsi proses, serta melakukan mengembangkan prosedur pembentukan bahasa program G-code yang sesuai dengan CNC controller. Setelah itu dalam penelitian ini, dilakukan trial pembuatan produk dengan menggunakan mesin CNC multifungsi yang menggabungkan 2 proses (milling dan pengukiran laser CO2) dalam sampel produk berupa dudukan telepon genggam (HP) yang diproduksi secara dalam 1 unit mesin produksi sekaligus. Proses metode milling, fungsi pemotongan laser ini diharapkan memberikan alternatif dan ruang desain baru bagi desain produk dalam pengembangan produknya di kemudian hari.
Perancangan Adjustable Mules Shoes Berbahan Soya Leather dari Limbah Tahu
Authors: Hilda Ummul Latifa  , Endro Tri Susanto  , RA Sekar Suminto
Published: February 2022

Tahu merupakan makanan olahan dari kedelai yang banyak dikonsumsi masyarakat Indonesia. Industri tahu saat ini banyak berkembang dalam skala kecil atau industri rumah tangga, sehingga dapat meningkatkan perekonomian masyarakat. Namun, industri ini juga memberi dampak negatif berupa limbah tahu yang dibuang sembarangan ke sungai. Hal ini mengakibatkan terganggunya ekosistem di area pembuangan limbah. Manusia yang terkontaminasi limbah dapat mengalami iritasi kulit, hingga dapat mengganggu sistem organ. Terdapat salah satu solusi, yakni inovasi teknologi pangan untuk mengolah limbah tahu menjadi nata de soya. Nata de soya dapat diolah kembali menjadi soya leather. Soya leather adalah lembaran menyerupai kulit, kain, dan kertas yang dapat digunakan sebagai kerajinan. Melihat industri kreatif yang berkembang saat ini, soya leather dapat menjadi material baru ramah lingkungan. Permukaan soya leather yang tidak terlalu luas, dapat diaplikasikan menjadi produk sepatu jenis mules shoes. Dikarenakan perkembangan industri sepatu di Indonesia meningkat di setiap tahunnya. Sepatu merupakan salah satu kebutuhan, khususnya wanita, yang kerap dijumpai mengalami kerusakan pada bagian belakang, karena terinjak dengan sengaja maupun tidak. Perancangan ini selain bertujuan untuk mengaplikasikan soya leather pada sepatu, juga meminimalisir kerusakan sepatu dengan sistem adjustable pada strap sepatu bagian belakang. Metode yang digunakan adalah design thinking, meliputi lima tahapan, yakni empathize, define, ideate, prototype, dan test. Dalam pengembangan material, diperlukan pengawasan berkala agar spesifikasi material sesuai dengan produk yang akan dirancang. Perancangan ini masih memerlukan pengembangan ide yang lebih luas agar hasil material dan produk dapat sesuai dan berkesinambungan.
Seguridad ampliacionista en el acuerdo de paz de Colombia (2016): seguridad humana, medio ambiente y paz territorial
Authors: Farfan Moreno William
Published: February 2022

Una de las principales preocupaciones del Acuerdo final para la terminación del conflicto y la construcción de una paz estable y duradera (2016) es garantizar, mediante estrategias de seguridad, los derechos económicos, sociales, culturales, políticos y ambientales de las poblaciones y territorios que, especialmente, se vieron afectados por el conflicto armado. Bajo este presupuesto, el objetivo del artículo es analizar los aspectos relacionados con la seguridad humana, medio ambiente y paz territorial en el Acuerdo final, con el fin de plantear algunas consideraciones acerca de su implementación. La metodología empleada fue el Análisis del Discurso Político (ADP) para sustentar que el Acuerdo final es un discurso político y, como tal, es susceptible de ser analizado empíricamente. La principal conclusión es la necesidad de implementar una política de seguridad en sentido amplio que tenga como centro la persona y las comunidades. Dicha seguridad se encuentra expresada en el punto de la reforma rural integral y, parcialmente, en el punto de la solución al problema del narcotráfico. Como conclusión, se plantea la necesidad de implementar dichos puntos con un enfoque de seguridad ampliada, especialmente, pero combinada con la seguridad tradicional limitadamente, sin que se traslapen para evitar nuevas violencias en los territorios.
Violencia intrafamiliar. Un riesgo para el desarrollo de la primera infancia
Authors: Docal Millán María del Carmen , Akl Moanack Paola María , Pérez García Leidys Yohana , Sánchez Betancourt Laura Katherine
Published: February 2022

Los padres y cuidadores son los adultos que apoyan a los niños y niñas para el desarrollo de los aspectos que constituyen la naturaleza humana, les proporcionan los significados y las nociones que concretan la dignidad de la persona en la familia y en los otros escenarios fuera de esta, por tanto, la exposición a la violencia intrafamiliar se constituye un riesgo para el desarrollo integral de los niños y las niñas. Objetivo: identificar tipos y formas de violencia intrafamiliar que sufren las madres y cuidadoras como un factor de riesgo en el desarrollo integral de los niños y niñas de un programa de primera infancia. Metodología: estudio cuantitativo, descriptivo transversal mediante cuestionario. Participaron 308 mujeres. Resultados: las participantes son víctimas de violencia psicológica, física, económica y sexual por parte de los miembros de sus familias de origen, política y propia. Conclusiones: es evidente el riesgo para el desarrollo integral de los niños y las niñas sobre reproducir los modelos de trato violento, dado que los actos de violencia son repetitivos en la historia familiar.
Narrativas de jóvenes con intentos suicidas: una mirada al cuerpo y la micropolítica
Authors: Cañón Sandra Constanza , Carmona Parra Jaime Alberto , Ortega Adriana Arroyo
Published: February 2022

Este artículo es el resultado de una investigación que da cuenta de la relación entre el intento de suicidio y la micropolítica en jóvenes de una institución educativa del municipio de Chinchiná, Caldas, Colombia. El referente teórico se basa en las discusiones en torno a los conceptos de micropolítica y cuerpo. La fundamentación epistemológica y metodológica fue fenomenológica hermenéutica. Todo esto dio la posibilidad de que los jóvenes en sus narrativas autobiográficas relataran sus vidas y encontraran nuevas posibilidades de existencia. Se encontraron categorías como: el encuentro con el mundo, un mundo sin cuidado, la violencia sexual, el cuerpo como espacio de comunicación, la incertidumbre, entre otras. Se concluye la importancia de comprender los procesos de singularización de los jóvenes para interpretar los sentidos que le dan al cuerpo y su relación con la micropolítica; asimismo, cómo los jóvenes manifiestan su rechazo a la producción de subjetividad capitalista a través del intento de suicidio.
Responsabilidad social en la red de salud de la Guajira colombiana
Authors: Martínez Salas Sayuris Yelind , Rodríguez López Cielo Margarita , López Juvinao Danny Daniel
Published: February 2022

La responsabilidad social es un concepto amplio donde se involucra la necesidad de responder a los grupos de interés con los que se interactúa; para el sector salud, este concepto es inseparable, ya que el Estado debe velar por hacer cumplir ciertos preceptos con el fin de garantizar la prestación de servicios en el territorio nacional, tomando en cuenta las diferencias y necesidades de cada uno de los municipios. Esta investigación tiene como propósito analizar la responsabilidad social en las secretarías de salud de la Guajira, Colombia. La investigación es descriptiva, de campo y no experimental. El instrumento fue la encuesta, misma que se aplicó a 58 personas de las secretarías de salud de 2 municipios de la Guajira colombiana. Se concluye que en el caso del Municipio Maicao no se tienen claros los elementos de la gestión de la responsabilidad social, aunque ponen en práctica algunos de los aspectos de la misma; mientras que en el municipio Uribia la gestión es deficiente, parecen desconocer el proceso, al mismo tiempo que los elementos no se toman en cuenta.
Estratégias participativas para a intervenção em saúde: relato de experiência no pet-saúde graduasus
Authors: Belasco Isabel Cristina , Patiño Rafael Andres
Published: February 2022

Este trabajo relata una experiencia de trabajo interdisciplinario desarrollada  por profesores, estudiantes de una Licenciatura en salud, profesionales de la salud y actores sociales de una comunidad, dentro del Programa de Educación para el Trabajo PET-Salud GraduaSUS. La primera parte del proyecto se concentró en un diagnóstico participativo de la situación de salud en la ciudad de Porto Seguro, Brasil, a partir del cual fueron planeadas acciones de intervención, junto con la comunidad. Específicamente, el texto presenta una serie de talleres realizados con, estudiantes de una escuela de la región, que apuntaron la violencia como uno de los principales problemas de su territorio. Los talleres fueron ofertados como un dispositivo de reflexión, articulación y elaboración de experiencias de violencia y, al mismo tiempo, como un espacio de reflexión y cuestionamiento de prácticas de discriminación y de violación de los derechos humanos, con las que los jóvenes tienen contacto en su cotidianidad. El trabajo reafirmo la potencia de las estrategias intervención social participativas para producir transformaciones sociales y subjetivas, inclusive en relación a problemas el campo de salud.
El barrio de Lavapiés (Madrid) visto desde la perspectiva patrimonial. Un lugar de resistencia que representa una oportunidad de mejora social
Authors: Giacomasso María Vanesa , Castillo Mena Alicia
Published: February 2022

En este trabajo se presenta la síntesis de un estudio llevado a cabo en la ciudad de Madrid (España), en torno a las percepciones sociales construidas sobre el barrio céntrico de Lavapiés con base en los valores patrimoniales. El análisis se basó en la identificación de agentes clave y sus significaciones, a partir de una metodología de investigación cualitativa que incluyó la elaboración de un mapeo de agentes, mapas cognitivos y la realización de entrevistas abiertas y en profundidad. El objetivo principal de este trabajo consistió en la elaboración de un diagnóstico actualizado del barrio que pueda ser de utilidad para el desarrollo de propuestas de mejora socioeconómica del patrimonio que permitan la participación de los propios habitantes en la toma de decisiones sobre el mismo.
Matemáticas en moldes para la elaboración de estructuras en artesanías de Usiacurí
Authors: Aroca Araújo Armando Alex , Santana Ríos Geraldine
Published: February 2022

El problema de esta investigación consistió en identificar las matemáticas presentes en los moldes o patrones para la elaboración de estructuras en alambres en la práctica artesanal del Municipio de Usiacurí. Esta investigación fue desarrollada con los artesanos de dicho municipio. El objeto de estudio principal fue analizar los moldes o patrones utilizados en la elaboración de estructuras en alambres en las artesanías de Usiacurí. La investigación está apoyada teóricamente en el programa de etnomatemática, la enculturación matemática y las investigaciones sobre las matemáticas presentes en las prácticas culturales en contextos distintos. Para ello se aplicó una metodología cualitativa-descriptiva abordada desde la etnografía, considerando las perspectivas socioculturales y particulares de los artesanos. En los resultados obtenidos se destacan los patrones más utilizados (bolitas, cuadros, rectangular, polígonos, biscochos o alfajor, entre otros), los tipos de patrones (patrón en cartulina, patrón en la mesa y patrón de estructura de alambre) y las técnicas de implementación de los patrones en la elaboración de estructuras en alambre en las artesanías de Usiacurí. Estos resultados se convierten en elementos ricos para la construcción de ambientes de aprendizajes y contribuyen a la relación entre los conocimientos matemáticos de la cultura local y el conocimiento matemático escolar.
Effects of brand innovation and marketing dynamic capability on the performance of international hotels
Authors: Sampetua Hariandja Evo , Sartika Lusiana
Published: February 2022

The Covid-19 epidemic has resulted in a dramatic decline in hotel public consumption. Hotel performance must be enhanced through the use of a hotel marketing strategy to compete with others. The aim of this paper is to examine the relationship between the innovation of the brand, dynamic capability of marketing, brand communication, brand experience, and brand performance in Indonesian 3-5 star international hotels. The data for this study were acquired using an electronic questionnaire on Google Forms from 530 customers who stayed in hotels throughout Indonesia prior to and during the Covid-19 pandemic. Smart-PLS 3.2.9 was used to analyze the data using the outer model and the inner model. The findings indicated as follows: brand innovation has a positive effect on brand communication; dynamic marketing capability has a positive influence on brand communication; brand communication directly has a positive effect on brand experience; brand experience significantly has a positive effect on brand performance; brand communication directly has a positive effect on brand performance; brand innovation has a positive influence on brand performance, and dynamic marketing capability has a positive effect on brand performance. This study contributes to the worldwide hotel strategy’s global marketing efforts in order to compete and improve performance in an increasingly competitive hotel business.
Intercultural Communication Competence: An International Students Experience in Indonesia
Authors: Pinariya Janette Maria , Sutjipto Aldila Maharani
Published: February 2022

The research aimed to analyze the intercultural communication competence based on international students’ experience in Indonesia and discussed how, in the globalization era, education had reached a new stage where the process of knowledge exchange had crossed national borders. However, educational institutions were not fully prepared to accommodate these modern needs. Although the study of intercultural communication was not new, concern for new cultural diversity had only received great attention lately, wherein the end, the Intercultural Communication Competence (ICC) in educational fields was still very low and must continue to be explored. The research applied a case and phenomenological study method with a descriptive qualitative approach. The data were gathered through semi-structured interviews and study literature. By analyzing the interactive multicultural building model, supported by the concept of intercultural communication and internationalization of higher education, the research results show that there are still inequalities and differences of opinion as well as an assessment of a three-perspective model that is used as the research focus. It consists of the affective process (intercultural sensitivity), cognitive process (intercultural awareness), and behavioral process (intercultural adroitness). Besides, there are various challenges that must be faced.
COGNIÇÃO SOCIAL DOS PROFESSORES SOBRE INTENCIONALIDADE EDUCATIVA A PARTIR DOS DOCUMENTOS OFICIAIS DO MINISTÉRIO DA EDUCAÇÃO
Authors: Almeida Rinaldi Amarante Paula , Xavier Senra Luciana
Published: February 2022

A nova Base Nacional Comum Curricular (BNCC) cita a intencionalidade educativa como norteador para a prática pedagógica e a Política Nacional de Alfabetização (PNA), proposta pelo Ministério da Educação-MEC, apresenta as contribuições da Ciência Cognitiva da Leitura. A partir dessa relação e com o aporte teórico da Teoria Social Cognitiva-TSC pretendeu-se conhecer como os professores da Educação Infantil-EI e 1° segmento do Ensino Fundamental-EF empregam intencionalidade no desenvolvimento das habilidades metalinguísticas e dos preditores de alfabetização, assim como compreendem os fundamentos cognitivos citados nos documentos. Foi realizada uma pesquisa qualitativa de caráter transversal, exploratória e descritiva, com 42 professores da EI e do 1° segmento do EF. A coleta de dados foi realizada em formato online por meio de questionário semi-estruturado para caracterização da amostra e investigar as percepções da amostra sobre o tema estudado. A análise dos dados ocorreu por meio de critérios frequenciais e temáticos norteados pela análise de conteúdo de Bardin. Os principais temas foram discutidos por meio das categorias globais: 1ª “Percepção da linguagem e habilidades metalinguísticas através do ditado”; 2ª “Percepção das habilidades referentes a Cognição Social”; e 3ª “Percepção sobre a formação acadêmica pedagógica e documentos do MEC”, com suas respectivas subcategorias e unidades de registro. Entre os elementos apurados, pode-se inferir urgência da referida percepção se evidenciou devido à modalidade de ensino ofertada desde a Educação Infantil no ano de 2020 devido a Pandemia por COVID-19. Os resultados permitiram constatar, que o conceito de Agência Humana e a Autoeficácia Docente da TSC podem contribuir na formação para um novo perfil docente, que sustenta suas práticas nos componentes cognitivos da autorreflexão, previsão e intencionalidade, buscando aprimoramento profissional e compreendendo as contribuições da Ciência da Leitura, referenciada pela PNA.
CORRUPÇÃO NO ENSINO REMOTO NA EDUCAÇÃO SUPERIOR DURANTE A PANDEMIA DO COVID-19 E A PERCEPÇÃO DE JUSTIÇA DOS ALUNOS
Authors: Colares Ana Carolina Vasconcelos , Miranda Lidiane Tereza Fagundes
Published: February 2022

O propósito deste estudo foi analisar a relação entre as corrupções cometidas por estudantes de graduação em Ciências Contábeis no Ensino Remoto Emergencial realizando durante a pandemia do COVID-19, e a percepção de justiça destes alunos. Estas corrupções abordadas se dão em especial nas avaliações que o corpo docente solicita que sejam efetuadas sem consulta a fontes externas e de forma. Para a pesquisa quantitativa foi utilizada uma adaptação da Escala de Percepção de Justiça Acadêmica utilizada por Chory (2007), Simil (2016) e atualizado por Costa (2017) que teve como amostra 200 graduandos de Ciências Contábeis. Foi realizada uma análise de regressão múltipla para identificar as variáveis relacionadas aos estudantes e à instituição que afetam a percepção de justiça distributiva. Como resultado obteve-se três variáveis estatisticamente significativas: o gênero, o desempenho acadêmico e a percepção de corrupção. Os resultados indicam que o gênero feminino e os estudantes que apresentam bom desempenho acadêmico possuem uma maior percepção de justiça, sendo que os alunos que julgam consultas à fontes externas como atos de corrupção tendem a avaliar como mais injusto os fins alcançados durante o ensino remoto. Além disso, observou-se que quase 30% dos respondentes fazem consultas ao material da disciplina, à internet e aos colegas durante as avaliações mesmo admitindo que seja um ato de corrupção, o que pode contribuir para a construção de uma cultura de corrupção generalizada, mesmo que sejam considerados como pequenas corrupções. Por fim, diante dos resultados apresentados, a pesquisa também traceja uma reflexão sobre as formas de avaliação do ensino superior, as quais poderiam ser mais focadas em aprendizagem através de projetos aplicativos ao invés de provas que demandam mais conhecimento teórico.
AÇÕES DE UM GRUPO DE PESQUISA NA PANDEMIA: CONTRIBUIÇÕES PARA A FORMAÇÃO CONTINUADA DE PROFISSIONAIS DA EDUCAÇÃO
Authors: Santos Mateus José Dos , Martins Sidney Pires , Mello Rita Márcia Andrade Vaz de
Published: February 2022

O presente trabalho aborda as contribuições de um grupo de estudos e pesquisas para profissionais da educação que busca desenvolver ações envolvendo a formação inicial e continuada articulados com a pesquisa, ensino e extensão no âmbito da Universidade Federal de Viçosa. O Grupo de Estudos e Pesquisas em Políticas Públicas e Formação de Profissionais da Educação (GEPPFOR) é vinculado ao Departamento da Educação da Universidade Federal de Viçosa e desempenhou durante a pandemia diversas atividades em prol de uma educação cada vez mais humana e que compreenda os desafios que afetam os profissionais da educação. A partir deste diagnóstico, os pesquisadores vinculados ao grupo passaram a atuar na minimização destes impactos, sobretudo àqueles escancarados pela pandemia da Covid-19. Embasado em uma pesquisa qualitativa fenomenológica, a presente proposta busca tecer contribuições referente às ações do GEPPFOR voltadas para a formação de profissionais da educação a partir das atividades desempenhadas durante a pandemia. As atividades realizadas mobilizam discussões necessárias e que podem provocar mudanças na práxis educativa. Além disso, as ações extensionistas executadas atuam na busca por estreitar laços entre a Educação Básica e a Universidade para que juntas possam atuar na proposição de situações de aprendizagem que contribuam para uma formação crítica e reflexiva na profissão docente.
Military revolution and state capacity of Jagiellonian states at the turn of the Middle Ages in European context
Authors:   Faculty of History and International Relations, Center for the Study of Demographic and Economic Structures in Preindustrial Central and Eastern Europe, University of Białystok, Guzowski Piotr
Published: February 2022

This article provides an overview of financial situation in the Kingdom of Poland and the Grand Duchy of Lithuania at the end of the Middle Ages and beginning of the early modern era when both states entered the period of military revolution. Military conflicts engaging the Kingdom and the Duchy in the 15th and especially in the 16th century were a catalyst for institutional and treasury reforms affecting crown/ducal domains and fiscal systems in both states. The reforms were aimed primarily at increasing the royal and ducal revenues, but in the long run they were conducive to political changes, the most important of which was the parliamentary union in 1569 and establishment of the Polish-Lithuanian Commonwealth. Although revenues increased and foreign policies of Jagiellonian states proved successful, their treasury systems were never fully modernized. Fixed taxes played a minimal role and allowed the state apparatuses to function relatively efficiently only during periods of peace. The crises, in turn, showed that the Jagiellons’ credit capacity was very limited. Compared to the most developed European countries, the revenue and financial capacity of the Kingdom of Poland, and even more so of the Grand Duchy of Lithuania, can be considered very modest.
Role of the Supporting Surface in the Thermodynamics and Cooperativity of Axial
Ligand Binding to Metalloporphyrins at Interfaces
Authors: Johnson Kristen N. , Chilukuri Bhaskar , Fisher Zachary E. , Hipps K.W. , Mazur Ursula
Published: February 2022

Metalloporphyrins have been shown to bind axial ligands in a variety of environments,
including the vacuum/solid and solution/solid interfaces. Understanding the dynamics
of such interactions is a desideratum for the design and implementation of next generation
molecular devices which draw inspiration from biological systems to accomplish diverse tasks
such as molecular sensing, electron transport, and catalysis to name a few. In this article, we
review the current literature of axial ligand coordination to surface-supported porphyrin receptors.
We will focus on the coordination process as monitored by scanning tunneling microscopy
(STM) that can yield qualitative and quantitative information on the dynamics and binding
affinity at the single molecule level. In particular, we will address the role of the substrate and
intermolecular interactions in influencing cooperative effects (positive or negative) in the binding
affinity of adjacent molecules based on experimental evidence and theoretical calculations.
Profiling of Biologically Active Metabolites of Spergula fallax L. Using High-resolution UPLC-QTOF-MS
Authors: Ibrahim Taghreed , Hegazy Mostafa , El-Hela Atef
Published: February 2022

Background:

Medicinal plants are recognized to have a wide range of important biological
activities, Spergula fallax L. is a well-known plant while phytochemical and biological activities
screening of the species are rare.

Objective::

This study aims to evaluate the antioxidant, anticáncer, antimicrobial, and antiviral activities
of the methanol extract (ME) of the aerial parts of Spergula fallax L. and its successive fractions;
n-hexane (HF), ethyl acetate (EAF), and n-butanol (BF) fractions and identify their biologically active
metabolites.

Method:

Ultra-performance liquid chromatography (UPLC) coupled to quadrupole high-resolution
time-of-flight mass spectrometry (QTOF-MS) was utilized to establish the metabolic profile of
Sergula fallax L. Total phenol and flavonoids content were determined colorimetrically using Folin
Ciocalteu and aluminum chloride reagents, respectively. 1,2-diphenyl-1-picrylhydrazyl (DPPH) was
utilized for estimation of antioxidant activity, cytotoxic activity was determined on Hep-G2, HCT-
116, and MCF-7 cell lines, and agar diffusion method was used for screening of antimicrobial activity
while cytopathic effect inhibition assay was utilized for antiviral assay.

Results:

Twenty-eight metabolites were identified, flavonoids were predominated (26), it was characterized
by the presence of four main aglycones (Apigenin, luteolin, quercetin and kaempferol) with
their O and/or C-glycosides based on its MS fragments. ME and EAF significantly scavenged DPPH
in a dose-dependent manner with IC50 16.99 and 18.74 μg.mL-1, respectively. Among the tested
samples, only ME and EAF showed significant cytotoxic activity against the tested cell lines with
IC50 ranging from 5.541- 9.509 μg.mL-1. All tested samples significantly inhibited the growth of the
tested bacterial strains with inhibition zone diameters ranging from 11.2- 26.4 mm and showed a
wide range of antiviral activity.

Conclusion:

Generally, S. fallax is potentially bioactive as evident by antioxidant, cytotoxic, antibacterial,
and antiviral assays. These activities are correlated with its identified metabolites. The
results proved that S. fallax has promising medicinal activities and would be examined in future clinical
trials for herbal therapy.
Combretastatin A4-loaded Poly (Lactic-co-glycolic Acid)/Soybean Lecithin Nanoparticles with Enhanced Drug Dissolution Rate and Antiproliferation Activity
Authors: Tao Jing , Cao Qing-Ri , Cao Yue , Ahmed Atef Mohammed Qasem , Du Huan-Huan , Sun Wei , Lu Xiaojuan , Xu Zhao
Published: February 2022

Objective:

This study aimed to prepare combretastatin A4 (CA4)-loaded nanoparticles (CA4
NPs) using poly(lactic-co-glycolic acid) (PLGA) and soybean lecithin (Lipoid S100) as carriers, and
further evaluate the physicochemical properties and cytotoxicities of CA4 NPs against cancer cells.

Methods:

CA4 NPs were prepared using a solvent evaporation technique. The effects of formulations
on CA4 NPs were investigated in terms of particle size, zeta potential, encapsulation efficacy, and drug
loading. The physicochemical properties of CA4 NPs were characterized using transmission electron
microscopy, X-ray powder diffraction, differential scanning calorimetry, and Fourier transform infrared
spectra. The drug release from CA4NPs was performed using a dialysis method. In addition, the cytotoxicity
of CA4NPs against human alveolar basal epithelial (A549) cells was also evaluated.

Results:

CA4 NPs prepared with a low organic/water phase ratio (1:20) and high drug/PLGA mass ratio
(1:2.5) exhibited a uniform hydrodynamic particle size of 142 nm, the zeta potential of -1.66 mV, and
encapsulation efficacy and drug loading of 92.1% and 28.3%, respectively. CA4 NPs showed a significantly
higher release rate than pure CA4 in pH 7.4 phosphate-buffered solution with 0.5% Tween 80. It
was found that the drug molecules could change from the crystal state to an amorphous form when
loaded into the PLGA/Lipoid S100 matrix, and some molecular interactions could also occur between
the drug and PLGA. Importantly, CA4 NPs showed a remarkably higher antiproliferation activity
against A549 cancer cells compared to pure CA4.

Conclusion:

These results suggested the promising potential of PLGA/Lipoid S100 nanoparticles as the
drug delivery system of CA4 for effective cancer therapy.
Privileged Scaffolds Targeting Bromodomain-containing Protein 4
Authors: Wang Ru , Wang Yi-Ang , Xu Yun-Gen , Shi Lei
Published: February 2022

In recent years, bromodomain-containing protein 4 (BRD4), a member of the bromodomain
and extra terminal domain (BET) family, has been one of the most widely studied targets.
BRD4 is a transcriptional regulation factor, which regulates cell transcription, marks mammalian
biological mitosis, regulates cell cycle, and plays an important role in the biological process of cancer
occurrence and development. It has been demonstrated that the imbalance or dysfunction of BRD4
expression leads to various types of cancers, including testicular gene nuclear protein melanoma,
acute myeloid leukemia, colon cancer, breast cancer, liver cancer, and midline cancer. Therefore,
inhibition of BRD4 has become a valuable approach in the treatment of these cancers. To date, there
are numerous BRD4 inhibitors in preclinical development, some of which have entered human clinical
trials. In this review, current progress in the development of privileged scaffolds designed as
BRD4 inhibitors will be discussed by focusing on structure-activity relationship, selectivity, and
mechanisms of action.
Tyrosinase Inhibition by Novel Benzimidazole-thione Schiff Base Derivatives
Authors: Zhou Wei , Tang Junyuan , Zhou Xinchong , Liu Jinbing
Published: February 2022

Background:

Tyrosinase is the enzyme responsible for the conversion of tyrosine to dopaquinone,
which is related to melanoma, neurodegenerative disorders, freckles, pigmented acne and age spots.
Controlling the tyrosinase activity could be an important way for treating overproduction of melanin.

Objective:

The development of safe and specific tyrosinase inhibitors could be used to treat hypermelanosis.

Methods:

5-nitro-1H-benzo[d]imidazole-2(3H)-thione was synthesized from 4-nitro-o-phenylenediamine
and carbon disulfide. The nitro group of 5-nitro-1H- S-1 ESI-HRMS benzo[d]imidazole-2(3H)-thione was
reduced with iron powder. The 5-amino-1H-benzo[d]imidazole- 2(3H)-thione Schiff base derivatives
were obtained by the reaction of 5-amino-1H-benzo[d]imidazole-2(3H)-thione with substituted benzaldehyde.
The tyrosinase inhibitory activities were investigated. The studies of kinetic analysis, metalchelating
properties, docking and cytotoxicity were also performed.

Results:

All of the compounds showed strong tyrosinase inhibitory activities with 5-((4-nitrobenzylidene)
amino)-1H-benzo [d]imidazole-2(3H)-thione (S-4) as the best tyrosinase inhibitor with an IC50 value of
4.8 ± 1.4 nM. Compound S-4 exhibited mixed type inhibition of mushroom tyrosinase, with Ki 15 nM
and Kis 42 nM. Copper binding to S-4 was detected spectrophotometrically and 1-100 μΜ S-4 displayed
negligible cytotoxicity to murine B16 melanoma cells.

Conclusion:

Our results demonstrated that these benzimidazolethione Schiff base derivatives might be
promising candidates as tyrosinase inhibitors.
In Silico Studies to Develop New GSK3β Inhibitors Effective in the
Alzheimer's Disease
Authors: Ozkat Gozde Yalcin , Yildiz Ilkay
Published: February 2022

Background:

Alzheimer's disease affects a large part of the world’s population by prolonging
the human life span and becoming an economic burden in the health system. Therefore, its treatment becomes
more and more important every day. With the insufficiency of existing drug molecules, new drug
targets are being searched. The most important of these is the Glycogen Synthase Kinase 3β enzyme,
which is thought to be of key importance in Tau hyperphosphorylation and Amyloid β accumulation
mechanisms.

Objective:

In this research, computational studies were conducted to develop a new GSK3β enzyme inhibitor.

Method:

Leading compounds suitable for pharmacophore models obtained by the 3D QSAR method
were scanned in databases. In silico ADME/Tox analyses were performed on the obtained molecules.

Results:

Although the three molecules (ENA99104, CNR13756, TIM405938) had strong Dock Scores
(42.869, 53.344, and 41.119, respectively) in molecular docking calculations, only the CNR13756 molecule
was found successful according to molecular dynamics simulations.

Conclusion:

All computational studies have revealed that the CNR13756 molecule can exhibit a therapeutic
scaffold property, thus obtaining a selective GSK3β inhibitor with minimal side effects.
Necrotizing Fasciitis After Total Hip Arthroplasty: A Rare Case Presentation
Authors: Aytekin Kürşad , Aytekin Feyza Yildiz
Published: February 2022

Background:

Necrotizing fasciitis (NF) is a life-threatening disease. Arthroplasty pa-tients with underlying or preexisting conditions and chronic medication use are prone to infection. The current report aimed to present a 53 years old female patient who developed necrotizing fasciit-is one month after total hip arthroplasty.

Case presentation:

On the postoperative 15th day, she had wound discharge. She was given oral an-ti-biotherapy. At postoperative 1 month, her complaints increased. At emergency service, she expe-rienced extreme pain in her lower extremity with pseudoparalysis, and a hip X-ray revealed gas im-ages. She used prednisolone for 10 years and insulin for 15 years because of pemphigus vulgaris and diabetes mellitus. Clinical and laboratory findings led us to the diagnosis of necrotizing fasciit-is. Despite aggressive treatment, including debridement, prosthesis removal, and antibiotherapy, un-fortunately, the patient died 13 days after admission.

Conclusion:

Patients with an immune suppressive condition, long-term corticosteroid use, or multi-ple underlying diseases should be closely monitored after total hip arthroplasty surgery to avoid such a devastating complication.
Association between Statin Use and Poor Outcomes in COVID-19 Patients
with Diabetes Mellitus: A Systematic Review
Authors: Audrey Jessica , Wisnu Wismandari , Tahapary Dicky L.
Published: February 2022

Background and Aims:

Diabetes mellitus, cardiovascular diseases, obesity, and dyslipidaemia
are considered risk factors for more severe forms of COVID-19 infection. Statins have
been widely used in such patients to prevent the occurrence of cardiovascular events and the associated
mortality. However, statin use has been suggested to promote a more severe form of infection.
This review aims to investigate the association between statin use and poor outcomes in
COVID-19 patients with diabetes.

Methods:

Literature search was performed in PubMed, CENTRAL, Scopus, and pre-print databases
(MedRxiv and BioRxiv), and studies published up to March 6th, 2021 have been reviewed.
Selected studies were then assessed for risk of bias with the Newcastle Ottawa Scale.

Result:

Four studies were included in the final analysis; all were retrospective studies. Two studies
reported a decreased risk of mortality with statin use, while one study reported opposite findings.
The other one did not find a significant association between statin use and poor COVID-19 outcomes.

Conclusion:

Available data suggest that statins may be safely administered to diabetic COVID-19
patients as the majority of evidence signifies statins to confer benefits and improve clinical outcomes
in COVID-19 patients.