bluuebunny/crossref_metadata_2025 huggingface dataset:
Looking Closer at the Patterns of Land Cover in the City of Porto, Portugal, between 1947 and 2019—A Contribution for the Integration of Ecological Data in Spatial Planning
Authors: Guilherme Filipa , Moreno Eva García , Gonçalves José Alberto , Carretero Miguel A. , Farinha-Marques Paulo
Published: October 2022

As more people reside in cities and metropolitan areas, urban vegetation assumes an increasingly important role as one the main providers of ecosystem services in close proximity to human agglomerations. To improve the conditions for citizens and to optimise the sustainability of urban areas, the fields of landscape and urban ecology need to address the urgent priority to integrate ecological data in spatial planning, design, and management programs. With the objective to produce “actionable knowledge” for urban planning in the city of Porto (Portugal), we analyse the evolution of land cover since the mid-20th century at a fine spatial scale. Porto has followed the global trends of urbanisation, marked by a general increase in built-up and impervious surfaces that conquered the previously rural surrounding areas. This caused a severe decline in vegetation cover (especially herbaceous), as well as an increase in fragmentation and isolation of the remaining vegetation patches. These outcomes provide a detailed analysis of the city spatial dynamics, generating valuable information that can be relevant for future interventions regarding urban landscape change at a local scale, the most relevant for planning.
Deploying the Total Operating Characteristic to Assess the Relationship between Land Cover Change and Land Surface Temperature in Abeokuta South, Nigeria
Authors: Bilintoh Thomas Mumuni , Ishola Juwon Isaac , Akansobe Adeline
Published: October 2022

Urbanization affects land cover and a region’s prevailing land surface temperature (LST). As a result, understanding the effects of urbanization on LST and land cover change is critical for effectively planning, managing, and monitoring urban development and undesired LST change. This paper, therefore, examines the relationship between the change in four land cover categories and LST during 1987–2004 and 2004–2021. Our approach uses the Total Operating Characteristic (TOC) to study the relationship between LST change and the losses and gains in four land cover categories: infrastructure, vegetation, water, and bare land in Abeokuta South, Nigeria. We derived the land cover and LST dataset from satellite imagery at time points 1987, 2004, and 2021. Our results show that most of the vegetation in the study area transitions to bare land and infrastructure during both time intervals, while most of the bare areas transition to infrastructure and vegetation. Furthermore, the TOC analysis shows vegetation loss, gain in infrastructure, and bare land occurs more intensively at segments between increased thresholds of LST values during both time intervals. Conversely, vegetation gain, infrastructure, and bare land loss occur more intensely at segments between decreased LST values. The methods discussed herein can reveal important insights and stimulate the needed conversation concerning the effective planning, managing, and monitoring of urban development and undesired LST change.
Land Use and Social Dynamics in Early 19th Century Bova, Calabria
Authors: Lazrus Paula Kay
Published: October 2022

While interest in land use in the prehistoric periods in Italy has received attention, that cannot be said of the Post-Medieval period. The general view is that all activities and objects from the last 300–500 years or so are so indecipherable from their contemporary counterparts and that there is no need to study them. There is, in fact, very little Post-Medieval archaeological work done in the south of Italy, which is the focus of this paper. The landscape of southern Calabria has changed radically over the centuries. The distribution of dense macchia forests was diminished in the late 18th and 19th centuries for building railroads and ships, and more recently, arson has been used as social or political revenge. The removal of the macchia led to erosional landscapes and the loss of archaeological footprints. This paper explores agricultural practices and forest exploitation in the early 19th and 20th centuries by the citizens of Bova to better understand the social and economic dynamics that continue to influence the lives of people living in the community. It utilizes cadastral records, archival documents from the early 1800–1900s, and spatial analysis to better understand the potential economic and social dynamics in this community. Consideration is also given to how social status and power, represented by Church-owned vs. lay citizen-owned properties, was reflected in local land use. The overall paucity of archaeological materials from this period across the landscape supports and complicates the overall picture while also supporting an interpretation of a very local and insular community poorly integrated into the greater Italian economy of the day.
Water Use Efficiency of Maize (Zea mays L.) Crop under Selected Soil and Water Conservation Practices along the Slope Gradient in Ruzizi Watershed, Eastern D.R. Congo
Authors: Bagula Espoir Mukengere , Majaliwa Jackson-Gilbert Mwanjalolo , Basamba Twaha Ali , Mondo Jean-Gomez Mubalama , Vanlauwe Bernard , Gabiri Geofrey , Tumuhairwe John-Baptist , Mushagalusa Gustave Nachigera , Musinguzi Patrick , Akello Sarah , Egeru Anthony , Tenywa Moses Makooma
Published: October 2022

Maize (Zea mays L.) productivity is constrained by water shortages in the predominantly rainfed agriculture of the tropical semi-arid Ruzizi Plain, in the eastern Democratic Republic of Congo (DRC). The region is characterized by a high seasonal and inter-annual rainfall variability and a frequent occurrence of consecutive dry days within growing seasons. Consequently, planning water utilization in rainfed agriculture has become complex, as appropriate soil water conservation (SWC) practices are lacking among most smallholder farmers. Identifying practices that increase water use efficiency (WUE) along the slope gradient is crucial for supporting maize production in the region. In this study, we assessed, for three growing seasons, the effectiveness of two SWC practices (tied ridges and Zai pits) in improving the WUE of two maize varieties along three slope gradients (0–2, 2–8, and 8–15%) in the tropical semi-arid Ruzizi Plain. In this area, rainfall amounts (142–289 mm) were consistently below the evapotranspiration demands (356–533 mm) across the three growing seasons. Tied ridges recorded the highest grain yield (2.16 t ha−1) and WUE (15.23 kg mm−1), especially at low slopes, when compared to Zai pits and conventional tillage. For all SWC practices, WUE decreased with the slope gradient (p < 0.01). Furthermore, a decrease in stored soil water (SWS) at silking and maturity stages (milk, dough, and dent stages) negatively affected the WUE. The variety had no significant effect on grain yield and WUE. Root biomass (RBM), shoot biomass (SBM), and leaf area index (LAI) at the flowering stage were the most associated with the WUE (R2 = 58.5%). In conclusion, tied ridges showed potential for improving maize WUE and yield in the water-deficient conditions that characterize the Ruzizi Plain, and could be promoted to improve the maize productivity among smallholder farmers.
Resilience Assessment of Traffic Networks in Coastal Cities under Climate Change: A Case Study of One City with Unique Land Use Characteristics
Authors: Wei Meng , Xu Jiangang , Wang Yiwen
Published: October 2022

How to assess the risk of flood disasters and improve the resilience of coastal cities has become a scientific problem that must be solved urgently. This paper aims to construct a resilience assessment model for transport systems in the context of climate change based on an analysis of the spatial characteristics of regional transport networks and complex network theory, using the Pudong New Area in Shanghai, China as the empirical object. Other objectives of the developed model are to establish a system of homogeneity, efficiency, and stability indicators and to assess the impact of flood depth (up to 7 m) on the resilience of transport networks in terms of static network structure and dynamic network performance by designing flood inundation disturbance scenarios. Finally, the characteristics, change trends, and conceptual connotations of the resilience of transport networks in coastal cities are condensed. The results of this study provide a solid scientific basis for future flood disaster risk management in global coastal cities.
Spatial Patterns Exploration and Impacts Modelling of Carbon Emissions: Evidence from Three Stages of Metropolitan Areas in the YREB, China
Authors: Ding Yichen , Huang Yaping , Xie Lairong , Lu Shiwei , Zhu Leizhou , Hu Chunguang , Chen Yidan
Published: October 2022

Metropolitan areas in China are not only the core spatial carriers of urbanization development but also the main generators of land use carbon emission (LUCE). However, existing research lacks comparative studies on the differential patterns and impact factors of LUCE in different stages of metropolitan areas. Therefore, this paper deeply analyzes the spatial characteristics of LUCE and the coupling coordination degree (CCD) of the economy contributive coefficient (ECC) and ecological support coefficient (ESC) in three different stages of metropolitan areas in the Yangtze River Economic Belt (YREB), China. Moreover, quantitative modelling of the impact factors of LUCE in these different stages of metropolitan areas is furtherly revealed. Results show that: (1) The more mature stage of the metropolitan area, the higher the amount of LUCE, and the more districts or counties with high carbon emissions levels are clustered. (2) At the metropolitan area scale, the more mature the metropolitan area is and the lower the CCD between ECC and ESC is, while at the finer scale, more developed counties have lower CCD. (3) Resident population, per capita GDP, and urbanization rate have good explanatory effects on carbon emissions in these three metropolitan areas; however, except for the urbanization rate, which has a negative effect on LUCE in Nanchang metropolitan area (NMA), the other two factors have positive effects on LUCE in these three metropolitan areas. This study has important implications for different stages of metropolitan areas to formulate targeted LUCE reduction policies.
How Do Cooperatives Alleviate Poverty of Farmers? Evidence from Rural China
Authors: Shen Yun , Wang Jinmin , Wang Luyao , Wu Bin , Ye Xuelan , Han Yang , Wang Rui , Chandio Abbas Ali
Published: October 2022

Farmers’ cooperatives play an important role in enabling small farmers to integrate into modern agriculture. Based on the survey data of 7200 farmers in four provinces of China, this paper uses the multi-dimensional poverty measurement method and the instrumental variable method to reveal the transmission mechanism and multi-dimensional poverty reduction effect of farmers’ cooperatives in deep poverty-stricken areas in China to realize joint agricultural empowerment through the supply chain. The results show that farmers’ cooperatives play an important role in enhancing small farmers’ financing, technology application, market sales, and rights decision-making. Every increase in the degree of interest connection between the two will help farmers reduce the multi-dimensional poverty level by 12.3%, and the mitigation effects on material poverty, ability poverty, and rights poverty are between 10% and 13%. Compared with agricultural cooperatives with weak organizational service capacity, cooperatives with high organizational service capacity have a more significant multi-dimensional poverty reduction effect on farmers, which leads to farmers obtaining financing and improving their ability and income. In addition, the difference in benefit coupling between agricultural cooperatives and farmers of different leading bodies also results in the heterogeneity of multi-dimensional poverty alleviation effects of farmers. To a certain extent, the supply chain is affected by the risk endowment of members, the supply chain’s poverty alleviation performance is affected by members’ supply chain’s poverty alleviation performance, and there is a certain risk transfer and “distribution failure”. Therefore, optimizing the benefit coupling structure and risk sharing mechanism between farmers’ cooperatives and farmers has become an important way to break the pattern of “the strong are always strong” and “distribution failure” for supply chain members and farmers.
Spatio-Temporal Analysis of the Effects of Human Activities on Habitat Quality: A Case Study of Guiyang City, Guizhou Province, China
Authors: Gao Shunqian , Yang Liu , Jiao Hongzan
Published: October 2022

In recent years, regional habitat quality (HQ) has significantly degenerated, mainly attributed to human activities. Evaluating the spatio-temporal effects of human activities on HQ is crucial for maintaining regional ecosystem and conservation of landscapes. In this paper, taking Guiyang city as a case study, the spatio-temporal patterns of HQ and human footprint (HF) in 2000, 2010 and 2020 were respectively calculated by the HQ model and human footprint index (HFI). Then, the bivariate local Moran’s I was applied to measure the spatial relationship between them. Urban development zoning was conducted on the basis of the spatio-temporal relationship. The results showed that (1) in the past 20 years, HQ in Guiyang city was mainly dominated by relatively high value areas (moderately high and high), accounting for more than 60% of the total area. The proportion of low HQ area increased from 12.5% in 2000 to 18.5% in 2020, indicating that urban development has caused the continuous degradation of HQ. (2) The human activities in Guiyang city undergone apparent changes. The area of low HF decreased from 51.5% in 2000 to 46.7% in 2020, while the area with high-value increased from 2% to 5.8%. (3) There was a significantly negative correlation between HQ and HF in Guiyang city. The increasing correlation coefficient indicated that the impact of human activities on HQ has been strengthening. (4) Based on the spatial zoning scheme, the territorial space of Guiyang city was divided into four types, that is, the core development zone, the moderate development zone, the habitat conservation zone and the prohibited development zone. A series of corresponding strategies were proposed for the characteristics of each zone. Our findings can serve as guidance to urban managers and policy-makers for adopting suitable urban development plans and appropriate management of natural environment.
Expletive Subject Clitics in Northern Italo-Romance
Authors: Pescarini Diego
Published: October 2022

This article examines the syntax of subject clitics in northern Italian dialects. Statistical analysis is performed on a sample of 350 dialects to show that the co-variation between syntactic variables is significant. The variables under examination are the occurrence of subject clitics with non-dislocated subjects (e.g., the wh element who); the occurrence of subject clitics with nonthematic predicates (e.g., weather verbs); and the occurrence of subject clitics with subjects of any person. Syntactic variables are in turn linked to verbal agreement; in the above contexts, clitics are more readily found in dialects with “poor” inflection. Theoretical issues concerning the syntactic representation of subject clitics, null subjects, and doubling are addressed in light of quantitative findings.
Comment on Liu et al. Application of High-Flow Nasal Cannula in COVID-19: A Narrative Review. Life 2022, 12, 1419
Authors: Crimi Claudia , Cortegiani Andrea
Published: October 2022

We read the article “Application of High-Flow Nasal Cannula in COVID-19: A Narrative Review” by Liu and colleagues [...]
Endothelin System and Ischemia-Induced Ventricular Tachyarrhythmias
Authors: Mouchtouri Eleni-Taxiarchia , Konstantinou Thomas , Lekkas Panagiotis , Kolettis Theofilos M.
Published: October 2022

Despite the contemporary treatment of acute coronary syndromes, arrhythmic complications occurring prior to medical attendance remain significant, mandating in-depth understanding of the underlying mechanisms. Sympathetic activation has long been known to play a key role in the pathophysiology of ischemia-induced arrhythmias, but the regulating factors remain under investigation. Several lines of evidence implicate the endothelin system (a family of three isopeptides and two specific receptors) as an important modulator of sympathetic activation in the setting of acute coronary syndromes. Such interaction is present in the heart and in the adrenal medulla, whereas less is known on the effects of the endothelin system on the central autonomic network. This article summarizes the current state-of-the-art, placing emphasis on early-phase arrhythmogenesis, and highlights potential areas of future research.
Mulberry (Morus alba L.) Leaf Extract and 1-Deoxynojirimycin Improve Skeletal Muscle Insulin Resistance via the Activation of IRS-1/PI3K/Akt Pathway in db/db Mice
Authors: Kang Chae-Won , Park Miey , Lee Hae-Jeung
Published: October 2022

Mulberry (Morus alba L.) leaves have been used to lower blood glucose in patients with diabetes. We evaluated the effects of mulberry leaves extract (MLE) and 1-deoxynojirimycin (1-DNJ) in improving insulin resistance through the activation of the IRS-1/PI3K/Akt pathway in the skeletal muscle of db/db mice. Histological analysis revealed an amelioration of muscle deformation and increased muscle fiber size. MLE and 1-DNJ positively raised the protein expression of related glucose uptake and increased the translocation of glucose transporter type 4 (GLUT4) to the membrane. Furthermore, MLE and 1-DNJ activated the IRS-1/PI3K/Akt pathway in the skeletal muscle and, subsequently, modulated the protein levels of glycogen synthase kinase-3beta (GSK-3β) and glycogen synthase (GS), leading to elevated muscle glycogen content. These findings suggest that MLE and 1-DNJ supplementation improves insulin resistance by modulating the insulin signaling pathway in the skeletal muscle of db/db mice.
Predicting Health Risks of Adult Asthmatics Susceptible to Indoor Air Quality Using Improved Logistic and Quantile Regression Models
Authors: Bae Wan D. , Alkobaisi Shayma , Horak Matthew , Park Choon-Sik , Kim Sungroul , Davidson Joel
Published: October 2022

The increasing global patterns for asthma disease and its associated fiscal burden to healthcare systems demand a change to healthcare processes and the way asthma risks are managed. Patient-centered health care systems equipped with advanced sensing technologies can empower patients to participate actively in their health risk control, which results in improving health outcomes. Despite having data analytics gradually emerging in health care, the path to well established and successful data driven health care services exhibit some limitations. Low accuracy of existing predictive models causes misclassification and needs improvement. In addition, lack of guidance and explanation of the reasons of a prediction leads to unsuccessful interventions. This paper proposes a modeling framework for an asthma risk management system in which the contributions are three fold: First, the framework uses a deep learning technique to improve the performance of logistic regression classification models. Second, it implements a variable sliding window method considering spatio-temporal properties of the data, which improves the quality of quantile regression models. Lastly, it provides a guidance on how to use the outcomes of the two predictive models in practice. To promote the application of predictive modeling, we present a use case that illustrates the life cycle of the proposed framework. The performance of our proposed framework was extensively evaluated using real datasets in which results showed improvement in the model classification accuracy, approximately 11.5–18.4% in the improved logistic regression classification model and confirmed low relative errors ranging from 0.018 to 0.160 in quantile regression model.
Organic Amendments for Mitigation of Salinity Stress in Plants: A Review
Authors: Hoque Md. Najmol , Imran Shahin , Hannan Afsana , Paul Newton Chandra , Mahamud Md. Asif , Chakrobortty Jotirmoy , Sarker Prosenjit , Irin Israt Jahan , Brestic Marian , Rhaman Mohammad Saidur
Published: October 2022

Natural and/or human-caused salinization of soils has become a growing problem in the world, and salinization endangers agro-ecosystems by causing salt stress in most cultivated plants, which has a direct effect on food quality and quantity. Several techniques, as well as numerous strategies, have been developed in recent years to help plants cope with the negative consequences of salt stress and mitigate the impacts of salt stress on agricultural plants. Some of them are not environmentally friendly. In this regard, it is crucial to develop long-term solutions that boost saline soil productivity while also protecting the ecosystem. Organic amendments, such as vermicompost (VC), vermiwash (VW), biochar (BC), bio-fertilizer (BF), and plant growth promoting rhizobacteria (PGPR) are gaining attention in research. The organic amendment reduces salt stress and improves crops growth, development and yield. The literature shows that organic amendment enhances salinity tolerance and improves the growth and yield of plants by modifying ionic homeostasis, photosynthetic apparatus, antioxidant machineries, and reducing oxidative damages. However, the positive regulatory role of organic amendments in plants and their stress mitigation mechanisms is not reviewed adequately. Therefore, the present review discusses the recent reports of organic amendments in plants under salt stress and how stress is mitigated by organic amendments. The current assessment also analyzes the limitations of applying organic amendments and their future potential.
NARX Neural Network for Safe Human–Robot Collaboration Using Only Joint Position Sensor
Authors: Sharkawy Abdel-Nasser , Ali Mustafa M.
Published: October 2022

Background: Safety is the very necessary issue that must be considered during human-robot collaboration in the same workspace or area. Methods: In this manuscript, a nonlinear autoregressive model with an exog-enous inputs neural network (NARXNN) is developed for the detection of collisions between a manipulator and human. The design of the NARXNN depends on the dynamics of the manipulator’s joints and considers only the signals of the position sensors that are intrinsic to the manipulator’s joints. Therefore, this network could be applied and used with any conventional robot. The data used for training the designed NARXNN are generated by two experiments considering the sinusoidal joint motion of the manipulator. The first experiment is executed using a free-of-contact motion, whereas in the second experiment, random collisions by human hands are performed with the robot. The training process of the NARXNN is carried out using the Levenberg–Marquardt algorithm in MATLAB. The evaluation and the effectiveness (%) of the developed method are investigated taking into account different data and conditions from the used data for training. The experiments are executed using the KUKA LWR IV manipulator. Results: The results prove that the trained method is efficient in estimating the external joint torque and in correctly detecting the collisions. Conclusions: Eventually, a comparison is presented between the proposed NARXNN and the other NN architectures presented in our previous work.
Beneficial Effect of Pre-Hardening of Elements Manufactured by the SLA Technology
Authors: Pszczółkowski Bartosz , Lemecha Magdalena , Rejmer Wojciech , Ligier Krzysztof , Bramowicz Mirosław , Zaborowska Magdalena , Kulesza Sławomir
Published: October 2022

In this work the effect of preliminary curing on mechanical, physicochemical and tribological properties of SLA (Stereolithography Appearance) manufactured samples is presented. Three preliminary curing times of 5, 10 and 15 s were selected for SLA manufacturing. The materials’ friction, hardness and capacitance values were determined by ball cratering, Brinell method and electrochemical impedance spectroscopy, respectively. The obtained results showed that the mechanical property values changed most significantly after 10 s of preliminary curing, but friction wear and electrochemical capacitance showed greatest change for samples cured for 15 s. This effect may be explained by the domination of elongation of molecular chains in the first 10 seconds of preliminary curing and the gradual increase of branching processes during the next 15 s.
Benz[a]azulenequinones: Reaction of Benz[a]azulenes with Pyridinium Hydrobromide Perbromide
Authors: Shoji Taku , Yamazaki Akari , Sakata Naoko , Sekiguchi Ryuta , Ito Shunji , Yasunami Masafumi
Published: October 2022

A series of benz[a]azulenes reacted with pyridinium hydrobromide perbromide (PHBPB) in hydrous tetrahydrofuran yielding the corresponding benz[a]azulenequinones in moderate yields. The detailed structure of the benz[a]azulenequinone derivative obtained was clarified by single crystal X-ray analysis.
Magnetic and Resonance Properties of a Low-Dimensional Cobalt–Aluminum Oxide–Germanium Film Tunnel Junction Deposited by Magnetron Sputtering
Authors: Kobyakov Aleksandr V. , Patrin Gennadiy S. , Yushkov Vasiliy I. , Shiyan Yaroslav G. , Rudenko Roman Yu. , Kosyrev Nikolay N. , Zharkov Sergey M.
Published: October 2022

The temperature behavior of saturation magnetization and the temperature behavior of the integral signal intensity in electron magnetic resonance spectra is experimentally studied comprehensively using a low-dimensional Al2O3/Ge/Al2O3/Co (aluminum oxide–cobalt–aluminum oxide–germanium) tunnel junction with different deposition velocities of a ferromagnetic metal (Co) thin layer and non-magnetic layers (Al2O3/Ge/Al2O3). The cobalt ferromagnetic layer was deposited on aluminum oxide in two ways: in one cycle of creating the structure and with atmospheric injection before deposition of the cobalt layer. The thermomagnetic curves revealed the appearance of minima observed at low temperatures on both sides of the cobalt layer. Possible sources of precession perturbations at low temperatures can be explained by: the influence of the Al2O3 layer structure on the Al2O3/Co interface; residual gases in the working chamber atmosphere and finely dispersed cobalt pellets distributed over the cobalt film thickness. The work offers information of great significance in terms of practical application, for both fundamental physics and potential applications of ultrathin films.
Mathematical Formulations for Asynchronous Parallel Disassembly Planning of End-of-Life Products
Authors: Meng Leilei , Zhang Biao , Ren Yaping , Sang Hongyan , Gao Kaizhou , Zhang Chaoyong
Published: October 2022

Disassembly is one of the most time-consuming and labor-intensive activities during the value recovery of end-of-life (EOL) products. The completion time (makespan) of disassembling EOL products is highly associated with the allocation of operators, especially in parallel disassembly. In this paper, asynchronous parallel disassembly planning (APDP), which avoids the necessity to synchronize disassembly tasks of manipulators during the parallel disassembly process, is studied to optimize the task assignment of manipulators for minimal makespan. We utilize four mixed integer linear programming (MILP) formulations to identify the optimal solutions. A set of different-sized instances are used to test and compare the performance of the proposed models, including some real-world cases. Finally, the proposed exact algorithm is further compared with the existing approach to solving APDP. Results indicate that a significant difference exists in terms of the computational efficiency of the MILP models, while three of four MILP formulations can efficiently achieve better solutions than that of the existing approach.
A Method for Reducing Transcendental Dispersion Relations to Nonlinear Ordinary Differential Equations in a Wide Class of Wave Propagation Problems
Authors: Matskovskiy Andrey , Zavorokhin German , Petrov Pavel
Published: October 2022

A class of problems of wave propagation in waveguides consisting of one or several layers that are characterized by linear variation of the squared refractive index along the normal to the interfaces between them is considered in this paper. In various problems arising in practical applications, it is necessary to efficiently solve the dispersion relations for such waveguides in order to compute horizontal wavenumbers for different frequencies. Such relations are transcendental equations written in terms of Airy functions, and their numerical solutions may require significant computational effort. A procedure that allows one to reduce a dispersion relation to an ordinary differential equation written in terms of elementary functions exclusively is proposed. The proposed technique is illustrated on two cases of waveguides with both compact and non-compact cross-sections. The developed reduction method can be used in applications such as geoacoustic inversion.
Predicting Angle of Internal Friction and Cohesion of Rocks Based on Machine Learning Algorithms
Authors: Shahani Niaz Muhammad , Ullah Barkat , Shah Kausar Sultan , Hassan Fawad Ul , Ali Rashid , Elkotb Mohamed Abdelghany , Ghoneim Mohamed E. , Tag-Eldin Elsayed M.
Published: October 2022

The safe and sustainable design of rock slopes, open-pit mines, tunnels, foundations, and underground excavations requires appropriate and reliable estimation of rock strength and deformation characteristics. Cohesion (𝑐) and angle of internal friction (𝜑) are the two key parameters widely used to characterize the shear strength of materials. Thus, the prediction of these parameters is essential to evaluate the deformation and stability of any rock formation. In this study, four advanced machine learning (ML)-based intelligent prediction models, namely Lasso regression (LR), ridge regression (RR), decision tree (DT), and support vector machine (SVM), were developed to predict 𝑐 in (MPa) and 𝜑 in (°), with P-wave velocity in (m/s), density in (gm/cc), UCS in (MPa), and tensile strength in (MPa) as input parameters. The actual dataset having 199 data points with no missing data was allocated identically for each model with 70% for training and 30% for testing purposes. To enhance the performance of the developed models, an iterative 5-fold cross-validation method was used. The coefficient of determination (R2), mean absolute error (MAE), mean square error (MSE), root mean square error (RMSE), and a10-index were used as performance metrics to evaluate the optimal prediction model. The results revealed the SVM to be a more efficient model in predicting 𝑐 (R2 = 0.977) and 𝜑 (R2 = 0.916) than LR (𝑐: R2 = 0.928 and 𝜑: R2 = 0.606), RR (𝑐: R2 = 0.961 and 𝜑: R2 = 0.822), and DT (𝑐: R2 = 0.934 and 𝜑: R2 = 0.607) on the testing data. Furthermore, to check the level of accuracy of the SVM model, a sensitivity analysis was performed on the testing data. The results showed that UCS and tensile strength were the most influential parameters in predicting 𝑐 and 𝜑. The findings of this study contribute to long-term stability and deformation evaluation of rock masses in surface and subsurface rock excavations.
Salivary Exosomal MicroRNA-486-5p and MicroRNA-10b-5p in Oral and Oropharyngeal Squamous Cell Carcinoma
Authors: Faur Cosmin Ioan , Roman Rareș Călin , Jurj Ancuța , Raduly Lajos , Almășan Oana , Rotaru Horațiu , Chirilă Magdalena , Moldovan Mădălina Anca , Hedeșiu Mihaela , Dinu Cristian
Published: October 2022

Background and Objectives: The research aimed at evaluating the capacity of salivary exosomal miR-10b-5p and miR-486-5p for oral and oropharyngeal cancer detection. Materials and Methods: The saliva samples were harvested from histopathological diagnosed oral and oropharyngeal squamous cell carcinoma patients and healthy volunteer subjects. The exosomes were isolated by differential ultracentrifugation and quantified by Nano Track Analysis. The microRNAs were extracted and quantified from salivary exosomes by quantitative Real-Time Polymerase Chain Reaction. Results: This research comprised fifty participants. When compared to healthy controls, salivary exosomal miR-486-5p was elevated and miR-10b-5p was reduced in oral and oropharyngeal squamous cell carcinoma. Moreover, miR-486-5p had a high expression level in stage II of cancer in comparison to the other cancer stages. The cancer samples presented an increased exosome dimension compared to the control samples. Conclusions: Salivary exosomal miR-10b-5p and miR-486-5p have an altered expression in oral and oropharyngeal cancer.
Anti-CXCL8 Autoantibody: A Potential Diagnostic Biomarker for Esophageal Squamous Cell Carcinoma
Authors: Chen Huili , Sun Guiying , Han Zhuo , Wang Huimin , Li Jiaxin , Ye Hua , Song Chunhua , Zhang Jianying , Wang Peng
Published: October 2022

Background and Objectives: Esophageal squamous cell carcinoma (ESCC) is one of the most common malignancies. Anti-tumor associated antigen autoantibodies (TAAbs) can be used as biomarkers for tumor detection. The aim of this study was to identify a reliable TAAb as the diagnostic marker for ESCC. Materials and Methods: The Cancer Genome Atlas (TCGA) database was used to screen candidate genes. The mRNA expression of the key gene was then verified by micro array dataset GSE44021 from the Gene Expression Omnibus (GEO) database and the diag nostic value of the corresponding autoantibody to the key gene in ESCC was detected by enzyme-linked im muno sorbent assay (ELISA). Results: CXCL8 was identified as the key gene. The dataset GSE44021 showed that CXCL8 mRNA expression was prominently over-expressed in ESCC tissues compared with normal tissues. ELISA results showed that the level of anti-CXCL8 autoantibody in ESCC patients was significantly higher than in normal controls and the receiver operating char ac teristic (ROC) curve indicated that anti-CXCL8 autoantibody could discriminate ESCC patients from normal controls, with the area under the ROC curve (AUC) for the verification cohort, and the validation cohort were 0.713 and 0.751, respectively. Conclusions: Our study illustrated that anti-CXCL8 autoantibody had good diagnostic value, and may become a candidate biomarker for ESCC.
Spinal Meningioma Surgery in Octogenarians: Functional Outcomes and Complications over a 2-Year Follow-Up Period
Authors: Lenga Pavlina , Gülec Gelo , Bajwa Awais Akbar , Issa Mohammed , Kiening Karl , Ishak Basem , Unterberg Andreas W.
Published: October 2022

Background and Objectives: Population aging in industrial nations has led to an increased prevalence of benign spinal tumors, such as spinal meningiomas (SMs), in the elderly. The leading symptom of SM is local pain, and the diagnosis is confirmed after acute neurological decline. However, little is known about the optimal treatment for this frail patient group. Therefore, this study sought to assess the clinical outcome, morbidity, and mortality of octogenarians with SMs and progressive neurological decline undergoing surgery and to determine potential risk factors for complications. Materials and Methods: Electronic medical records dated between September 2005 and December 2020 from a single institution were retrieved. Data on patient demographics, neurological conditions, functional status, degree of disability, surgical characteristics, complications, hospital course, and 90-day mortality were collected. Results: Thirty patients aged ≥80 years who were diagnosed with SMs underwent posterior decompression via laminectomy and microsurgical tumor resection. The patients presented with a poor baseline history (mean CCI 8.9 ± 1.6 points). Almost all SMs were located in the thoracic spine (n = 25; 83.3%). Progressive preoperative neurological decline was observed in 21/30 (n = 21; 70%) patients with McCormick Scores (mMCS) ≥3, and their mean motor score (MS) was 85.9 ± 12.3. in the in-hospital and 90-day mortality rates were 6.7% and 10.0%, respectively. The MS (93.6 ± 8.3) and mMCS (1.8 ± 0.9) improved significantly postoperatively (p < 0.05). The unique risk factor for complications was the severity of comorbidities. Conclusions: Decompressive laminectomy and tumor removal in octogenarians with progressive neurological decline improved patient functional outcomes at discharge. Surgery seems to be the “state of the art” treatment for symptomatic SMs in elderly patients, even those with poor preoperative clinical and neurologic conditions, whenever there is an acceptable risk from an anesthesiological point of view.
The Rigid Adsorbent Lattice Fluid Model: Thermodynamic Consistency and Relationship to the Real Adsorbed Solution Theory
Authors: Brandani Stefano
Published: October 2022

The Rigid Adsorbent Lattice Fluid model has been shown to comply with all the requirements for thermodynamic consistency in the case of an adsorbent that does not undergo structural changes. This is achieved by introducing a correction to the reduced density function that multiplies the combinatorial term. A procedure to calculate the predicted adsorbed mixture activity coefficients has been presented that allows the production of excess Gibbs energy plots at a constant reduced grand potential. The predicted nonideality is structurally consistent with the Non-Ideal Adsorbed Solution Theory of Myers in terms of both its dependence on concentration and reduced grand potential. The ability to generate excess Gibbs energy values allows linking the new Rigid Adsorbent Lattice Fluid model to the traditional Real Adsorbed Solution Theory providing an alternative approach to predicting multicomponent adsorption based solely on pure component data.
Electrical Discharge Machining of Alumina Using Ni-Cr Coating and SnO Powder-Mixed Dielectric Medium
Authors: Okunkova Anna A. , Volosova Marina A. , Kropotkina Elena Y. , Hamdy Khaled , Grigoriev Sergey N.
Published: October 2022

Aluminum-based ceramics exhibit excellent wear resistance and hot hardness that are suitable for various responsible applications allowing products to work under extreme mechanical and thermal loads (up to 1000 °C). The problem of high-precision forming complex-shaped parts is a known engineering challenge due to the insulating properties of aluminum-containing ceramics and the formation of chemically active carbides in a hydrocarbon medium. The alternative approach for electrical discharge machining non-conductive sintered Al2O3 in the water-based medium using nickel-chrome plasma-vapor-deposed coating of 12 mm, SnO powder suspension (particle diameter of ⌀10 µm, concentration of 150 g/L), and brass wire-tool is proposed. The productivity was evaluated by calculating the material removal rate and discharge gap for various combinations of pulse frequency and duration. The maximal material removal rate of 0.0014 mm3/s was achieved for a pulse frequency of 30 kHz and pulse duration of 1.7–2.5 μs. The recommended value of the interelectrode gap is 48.0 ± 4.9 µm. The possibility of electrical discharge machining aluminum-containing insulating ceramics without using hydrocarbons, carbon and copper-group assisting measures was proposed and shown for the first time. The chemical content of the debris in the interelectrode gap between components of the materials was thermochemically analyzed.
Development of Three-Dimensional LES Based Meshless Model of Continuous Casting of Steel
Authors: Mramor Katarina , Vertnik Robert , Šarler Božidar
Published: October 2022

A large-eddy simulation (LES) based meshless model is developed for the three-dimensional (3D) problem of continuous casting (CC) of steel billet. The local collocation meshless method based on radial basis functions (RBF) is applied in 3D. The method applies scaled multiquadric (MQ) RBF with a shape parameter on seven nodded local sub-domains. The incompressible turbulent fluid flow is described using mass, energy, and momentum conservation equations and the LES turbulence model. The solidification system is solved with the mixture continuum model. The Boussinesq approximation for buoyancy and the Darcy approximation for porous media are used. Chorin’s fractional step method is used to couple velocity and pressure. The microscopic model is closed with the lever rule model. The LES model is compared to the two-equation Low Re k−ε turbulence Reynolds Averaged Navier–Stokes (RANS) model in terms of temperature, velocity and computational times. The LES model resolves transient character of vortices which RANS-type turbulence models are unable to tackle. The computational cost of LES models is considerably higher than in RANS. On the other hand, it results in a much lower computational cost than the direct numerical simulation (DNS). The paper demonstrates the ability of the method to solve realistic industrial 3D examples. Trivial adjustment of nodal densities, high accuracy, and low numerical diffusivity are the main advantages of this meshless method.
A Comprehensive Investigation on the Effects of Surface Finishing on the Resistance of Stainless Steel to Localized Corrosion
Authors: Messinese Elena , Casanova Luca , Paterlini Luca , Capelli Fausto , Bolzoni Fabio , Ormellese Marco , Brenna Andrea
Published: October 2022

The present research investigates the influence of surface roughness imparted by cold surface finishing processes on the localized corrosion resistance of stainless steel. Five different alloys were studied: ferritic AISI 430, martensitic AISI 430F, austenitic AISI 303, AISI 304L, and AISI 316L. It was demonstrated that the grinding process, executed on previously cold drawn bars, leads to an improvement in corrosion resistance according to the results obtained with electrochemical tests, namely, potentiostatic and potentiodynamic tests in chloride-rich environments, the salt spray test, and long-term exposure in urban and marine atmospheres. This allowed us to establish a trend among the different alloys regarding the resistance to pitting corrosion, which was assessed according to pitting potentials, critical chloride contents, and pitting initiation time. All the tests confirmed that surface finishing, as well as alloy chemical composition, is an important factor in controlling the corrosion resistance of stainless steel.
LC-HRMS-Based Non-Targeted Metabolomics for the Assessment of Honey Adulteration with Sugar Syrups: A Preliminary Study
Authors: Martinello Marianna , Stella Roberto , Baggio Alessandra , Biancotto Giancarlo , Mutinelli Franco
Published: October 2022

Honey is a natural product that is in great demand and has a relatively high price, thus making it one of the most common targets of economically motivated adulteration. Its adulteration can be obtained by adding cheaper honey or sugar syrups or by overfeeding honeybees with sugar syrups. Adulteration techniques are constantly evolving and advanced techniques and instruments are required for its detection. We used non-targeted metabolomics to underscore potential markers of honey adulteration with sugar syrups. The metabolomic profiles of unadulterated honeys and sugar beet, corn and wheat syrups were obtained using hydrophilic interaction liquid chromatography high-resolution mass spectrometry (LC-HRMS). The potential markers have been selected after data processing. Fortified honey (5%, 10% and 20%), honey obtained from overfeeding, and 58 commercial honeys were analyzed. One potential marker appeared with a specific signal for syrups and not for honey. This targeted analysis showed a linear trend in fortified honeys with a calculated limit of quantification around 5% of fortification.
Untargeted Metabolomic Approach to Study the Impact of Aging on Salivary Metabolome in Women
Authors: Bosman Pauline , Pichon Valérie , Acevedo Ana Carolina , Le Pottier Laëtitia , Pers Jacques Olivier , Chardin Hélène , Combès Audrey
Published: October 2022

Despite the growing interest in salivary metabolomics, few studies have investigated the impact of aging on the salivary metabolome. The alterations in metabolic pathways that occur with aging are likely to be observed in pathologies affecting older people and may interfere with the search for salivary biomarkers. It is therefore important to investigate the age-related changes occurring in the salivary metabolome. Using reversed phase liquid chromatography and hydrophilic interaction chromatography coupled to mass spectrometry used in positive and negative ionization modes, the salivary metabolic profiles of young (22 to 45 years old) and older people (55 to 92 years old) were obtained. Those profiles were compared with the use of XCMS online to highlight the under or overexpression of some metabolites with aging. A total of 60 metabolites showed differential expression with age. The identification of 26 of them was proposed by the METLIN database and, among them, 17 were validated by standard injections. Aging seemed to affect most of the main metabolic pathways (amino acid metabolism, Krebs cycle, fatty acid synthesis, and nucleic acid synthesis). Moreover, most of the metabolites that were over- or under-expressed with age in this study have already been identified as being potential biomarkers of diseases affecting older people, such as in Alzheimer’s disease. Special attention should be paid in the search for biomarkers of pathologies affecting the elderly to differentiate age-related changes from disease-related changes.
Electrochemical Quantification of H2O2 Released by Airway Cells Growing in Different Culture Media
Authors: Patella Bernardo , Vincenzo Serena Di , Zanca Claudio , Bollaci Luciano , Ferraro Maria , Giuffrè Maria Rita , Cipollina Chiara , Bruno Maria Giuseppina , Aiello Giuseppe , Russo Michele , Inguanta Rosalinda , Pace Elisabetta
Published: October 2022

Quantification of oxidative stress is a challenging task that can help in monitoring chronic inflammatory respiratory airway diseases. Different studies can be found in the literature regarding the development of electrochemical sensors for H2O2 in cell culture medium to quantify oxidative stress. However, there are very limited data regarding the impact of the cell culture medium on the electrochemical quantification of H2O2. In this work, we studied the effect of different media (RPMI, MEM, DMEM, Ham’s F12 and BEGM/DMEM) on the electrochemical quantification of H2O2. The used electrode is based on reduced graphene oxide (rGO) and gold nanoparticles (AuNPs) and was obtained by co-electrodeposition. To reduce the electrode fouling by the medium, the effect of dilution was investigated using diluted (50% v/v in PBS) and undiluted media. With the same aim, two electrochemical techniques were employed, chronoamperometry (CH) and linear scan voltammetry (LSV). The influence of different interfering species and the effect of the operating temperature of 37 °C were also studied in order to simulate the operation of the sensor in the culture plate. The LSV technique made the sensor adaptable to undiluted media because the test time is short, compared with the CH technique, reducing the electrode fouling. The long-term stability of the sensors was also evaluated by testing different storage conditions. By storing the electrode at 4 °C, the sensor performance was not reduced for up to 21 days. The sensors were validated measuring H2O2 released by two different human bronchial epithelial cell lines (A549, 16HBE) and human primary bronchial epithelial cells (PBEC) grown in RPMI, MEM and BEGM/DMEM media. To confirm the results obtained with the sensor, the release of reactive oxygen species was also evaluated with a standard flow cytometry technique. The results obtained with the two techniques were very similar. Thus, the LSV technique permits using the proposed sensor for an effective oxidative stress quantification in different culture media and without dilution.