bluuebunny/crossref_metadata_2025 huggingface dataset:
Kaligrafi Arab Selawat Asy-Syifa sebagai Objek Penciptaan Karya Seni Lukis Dekoratif
Authors: Rahman Hasbi , Widodo Triyono , Anggraini Swastika Dhesti
Published: August 2023

Seni Kaligrafi Arab merupakan sebuah media ekspresi sekaligus menjadi syiar kesenian Islam. Unsur yang membagun dalam seni kaligrafi yaitu bentuknya yang baik dan indah juga mengandung sebuah ungkapan pengalaman artistik dari seniman. Metode yang digunakan dalam penciptaan karya seni ini adalah teori Alma Hawkins yang dimulai dengan tahap eksplorasi, yakni penggalian informasi terhadap fenomena pada lingkungan kelurahan gading kasri, kecamatan Klojen, kota Malang tentang sikap warga terhadap pandemi COVID-19. Dari hasil informasi, ditetapkan sebuah ide gagasan untuk diekspresikan ke dalam karya seni kaligrafi. Hasil proses kreatif tersebut berupa enam karya lukis kaligrafi gaya dekoratif dan stilasi objek jenis khat tsuluts, riq’ah dan kufi. Penelitian ini bertujuan untuk mengetahui konsep penciptaan karya lukis kaligrafi yang terinspirasi dari lafaz selawat Asy-Syifa sebagai objek karya lukis bergaya dekoratif, proses produksi karya lukis kaligrafi dekoratif yang terinspirasi dari lafaz selawat Asy-Syifa, serta hasil karya berupa lafaz selawat Asy-Syifa dalam bentuk lukisan kaligrafi dekoratif dalam bentuk penyajian beserta analisisnya.
Kata kunci: seni, kaligrafi, lukis dekoratif
Asy-Syifa Arabic Calligraphy as An Object of The Creation of Decorative Painting Works
Arabic calligraphy art is a medium of expression as well as a symbol of Islamic art. The elements that build in the art of calligraphy, namely its good and beautiful shape, also contain an expression of the artist's artistic experience. The method used in Creation uses Alma Hawkins' theory which begins with the Exploration Stage, namely gathering information on phenomena in the Gading Kasri sub-district environment, Klojen sub-district, Malang city regarding residents' attitudes towards the COVID-19 pandemic. From the results of the information, an idea is determined to be expressed in the work. The results of the creative process are six works of calligraphy painting in decorative styles and stylized objects of the type tsuluts, riq'ah and kufi. This study aims to determine the concept of creating a calligraphic painting inspired by the Asy-Syifa selawat recitation as an object of a decorative style painting, the production process of a decorative calligraphic painting inspired by the Asy-Syifa selawat chant, as well as the result of the work in the form of the Asy-Syifa selawat chant in form of decorative calligraphic painting in the form of presentation and analysis.
Keywords: art, calligraphy, decorative painting
Students’ Grammatical Errors in Writing Descriptive Texts
Authors: Novelia Elfa , Faisal Faisal
Published: August 2023

The primary objective of this study was to investigate and describe the various types of grammatical errors observed in written descriptive texts of seventh-grade students. A quantitative research design was employed, aligned with the recommended research project design proposed by Creswell and Plano Clark (2011). The data collection process involved analyzing students' written descriptive texts. A total of 82 errors were identified and categorized according to their frequency, namely omission, misformation, addition, and misordering. The study argued that the nature of the formative assessment and the national examination, with an emphasis on grammatical dimensions, were significant factors influencing these errors. These findings provide valuable insights into comprehending specific grammatical error patterns, thus facilitating the development of targeted instructional strategies to address these issues effectively.
Keywords: descriptive texts; formative assessment; grammatical errors
Kesalahan Tata Bahasa Siswa dalam Menulis Teks Deskriptif
Penelitian ini bertujuan untuk menyelidiki dan menggambarkan jenis-jenis kesalahan gramatikal yang ditemukan dalam teks deskriptif tulisan siswa kelas tujuh. Penelitian ini menggunakan desain penelitian kuantitatif sesuai dengan desain proyek penelitian yang direkomendasikan oleh Creswell dan Plano Clark (2011). Data dikumpulkan menggunakan dokumen - teks deskriptif tulisan siswa. Ditemukan 82 kesalahan yang diklasifikasikan berdasarkan urutan kesalahan paling sering hingga paling jarang terjadi, yaitu penghilangan, pembentukan salah, penambahan, dan pengurutan yang salah. Penelitian ini berargumen bahwa faktor yang diyakini mempengaruhi kesalahan tersebut adalah sifat penilaian formatif dan ujian nasional, dengan penekanan pada dimensi gramatikal. Temuan ini memberikan wawasan berharga dalam memahami pola kesalahan gramatikal tertentu, sehingga memudahkan pengembangan strategi pembelajaran yang tepat untuk mengatasi masalah tersebut dengan efektif.
Kata kunci, teks deskriptif, asesmen formatif, kesalahan tata bahasa,
Peningkatan Motivasi dan Hasil Belajar Ansambel Musik dengan Model Project Based Learning (PjBL)
Authors: Nur Afifah Fathatin , Rahayuningtyas Wida , Hartono Hartono
Published: August 2023

Kegiatan pembelajaran dilakukan dengan metode ceramah di lapangan masih belum optimal dan masih banyak siswa yang hasil akademiknya rendah. Penelitian ini termasuk dalam penelitian tindakan kelas (PTK) yang bertujuan untuk meningkatkan motivasi dan hasil belajar siswa dengan model Project Based Learning (PjBL) pada KD 3.4 dan 4.4 dalam materi ansambel musik dengan mata pelajaran seni budaya. Penelitian ini dilakukan dalam dua siklus setiap siklusnya memiliki tahapan yang terdiri dari perencanaan, pelaksanaan, pengamatan, dan refleksi. Teknik pengumpulan data menggunakan angket, lembar unjuk kerja, dan lembar observasi keterlaksanaan pembelajaran. Sampel penelitian adalah siswa kelas VII H semester ganjil tahun pelajaran 2021/2022, dengan jum­lah siswa 36 orang dalam mata pelajaran seni budaya pada materi ansambel musik. Hasil penelitan: (1) Observasi keterlaksanaan pembelajaran siklus 1 dangan nilai 75 (tinggi) dan meningkat pada siklus 2 menjadi 95 (sangat tinggi); (2) Motivasi belajar siklus 1 dengan skor rata-rata 3,16 (tinggi) telah meningkat pada siklus 2 menjadi 3,35 (sangat tinggi); (3) Hasil belajar siswa pada sikus 1 diperoleh rata-rata 77,09 dan meningkat pada siklus 2 menjadi 84,26. Dapat disim­pulkan bahwa melalui model pembelajaran Project Based Learning dapat meningkatkan moti­vasi belajar ada materi ansambel musik.
Kata kunci: motivasi dan hasil belajar; ansambel music; project-based learning.
Increasing Motivation and Learning Outcomes of Musical Ensembles using Project Based Learning (PjBL) Models
Learning activities carried out using the lecture method in the field are still not optimal and there are still many students whose academic results are low. This research is included in classroom action research (CAR) which aims to increase student motivation and learning outcomes with the Project Based Learning (PjBL) model at KD 3.4 and 4.4 in music ensemble material with cultural arts subjects. This research was conducted in two cycles, each cycle has stages consisting of planning, implementa­tion, observation, and reflection. Data collection techniques used questionnaires, performance she­ets, and learning implementation observation sheets. The research sample was class VII H students in the odd semester of the 2021/2022 academic year, with a total of 36 students in the arts and culture subjects in the music ensemble material. The results of the research: (1) Observation of the implementation of learning in cycle 1 with a value of 75 (high) and increased in cycle 2 to 95 (very high); (2) Learning motivation in cycle 1 with an average score of 3.16 (high) has increased in cycle 2 to 3.35 (very high); (3) Student learning outcomes in cycle 1 obtained an average of 77.09 and increased in cycle 2 to 84.26. It can be concluded that through the Project Based Learning learning model, it can increase learning motivation for music ensemble material.
Keywords: motivation and learning outcomes; musical ensembles; project-based learning
Perilaku Phubbing pada Remaja dalam Hubungan Keluarga
Authors: Faizah Rizqika Sugma Putri  , Edwin Rochmad Mendiota  , Fiola Rosa Anggela  , Mutia Husna Avezahra
Published: August 2023

The process of developing times makes the development of technology and the internet also become more sophisticated. This is in line with the many conveniences offered for everyday life, such as the growing development of communication tools such as Smartphones. But even so, the existing developments also have more or less negative impacts. One of the negative impacts is the emergence of phubbing behavior in the community. This study describes the background behind the emergence of phubbing behavior in adolescence, especially in family relationships. This study uses a qualitative approach with data collection techniques using semi-structured interviews and participant observation as a whole. The study results show that the cause of phubbing behavior in adolescents during family events is due to an obsession with smartphones and FoMO (Fear of Missing Out). The obsession with smartphones found in the participants indicated that they felt left behind in all forms of information when not using smartphones, which was done because the participants had been used to playing smartphones since childhood and were not involved in conversations when gathering with family.

AbstrakProses berkembangnya zaman membuat perkembangan teknologi dan internet juga menjadi semakin canggih. Hal ini sejalan dengan banyaknya kemudahan yang ditawarkan untuk kehidupan sehari-hari, seperti semakin berkembangnya alat komunikasi seperti smartphone. Namun meskipun begitu, perkembangan yang ada juga sedikit banyak memiliki dampak negatif. Salah satu dampak negatif tersebut adalah munculnya perilaku phubbing pada masyarakat. Penelitian ini mendeskripsikan latar belakang di balik munculnya perilaku phubbing pada masa remaja, terutama dalam hubungan keluarga. Penelitian ini menggunakan pendekatan kualitatif dengan teknik pengumpulan data menggunakan wawancara semi-terstruktur dan observasi partisipan secara menyeluruh. Hasil penelitian menunjukkan bahwa penyebab perilaku phubbing yang terjadi pada remaja saat acara keluarga adalah karena obsesi terhadap smartphone dan FoMO (Fear of Missing Out). Obsesi terhadap smartphone yang ditemukan dalam partisipan menunjukkan bahwa mereka merasa tertinggal akan segala bentuk informasi bila tidak menggunakan smartphone, yang mana hal tersebut dilakukan karena partisipan sudah dibiasakan bermain smartphone sejak kecil dan tidak dilibatkan dalam obrolan saat berkumpul dengan keluarga.
Gambaran Job Engagement pada Anggota Organisasi Artpsium Fakultas Psikologi Universitas Negeri Malang
Authors: Charisma Septian Wiweka  , Charaka Bintang Nararya  , Robi Ilyasa  , Jati Fatmawiyati
Published: August 2023

An organization must have members who have good job engagement or work engagement in it so that they will carry out their work more actively and enthusiastically and are accompanied by positive thoughts. This research was conducted to find out the description of job engagement in the Artpsium organization so that it is hoped that it can become an evaluation and reference material to further advance the Artpsium organization itself. The method used in this study is a qualitative approach with a structured interview method so that researchers and participants can meet face-to-face in order to obtain more accurate data. The results of the study show that the job engagement of Artpsium administrators and members is influenced by several things including internal factors and external factors. Then, the higher the position held in the organization, the greater the job engagement, conversely, the lower the position or role, the smaller the job engagement. Another problem that exists is that several other parts of Artpsium, especially those that join other organizations and don't have an important role, tend to have low job engagement, both in their management and membership.

AbstrakSuatu organisasi harus memiliki anggota yang mempunyai job engagement atau keterikatan kerja yang baik di dalamnya sehingga akan menjalani pekerjaannya dengan lebih giat dan antusias serta diiringi dengan pikiran yang positif. Penelitian ini dilakukan untuk mengetahui gambaran job engagement yang ada di organisasi Artpsium. Metode yang digunakan dalam penelitian ini adalah pendekatan kualitatif dengan metode wawancara terstruktur agar peneliti dan partisipan dapat bertemu langsung secara tatap muka sehingga didapatkan data yang lebih akurat. Hasil penelitian menunjukkan bahwa job engagement pengurus maupun anggota Artpsium dipengaruhi oleh beberapa hal meliputi faktor internal dan faktor eksternal. Kemudian, semakin tinggi jabatan yang dimiliki dalam organisasi maka job engagement akan cenderung semakin besar, sebaliknya jika jabatan atau peran yang dimiliki semakin rendah maka job engagement-nya juga cenderung semakin kecil. Masalah lain yang ada adalah karena beberapa bagian Artpsium lain, khususnya yang mengikuti organisasi lain dan tidak memiliki peran penting, cenderung untuk memiliki job engagement yang rendah, baik dalam kepengurusan atau keanggotaannya.
Concordancia entre una prueba in-house de inmunofluorescencia indirecta y un test comercial de hemoaglutinación indirecta para la detección de anticuerpos anti-Trypanosoma cruzi
Authors: Chamorro Luz , Giménez Vivian , Sanabria Diana , Godoy Ana María , Liuzzi Cinthia , Carpinelli María Mercedes , Benegas Sara
Published: August 2023

El diagnóstico serológico de la enfermedad de Chagas, causada por Trypanosoma cruzi, carece de “gold standard”, siendo considerada la inmunofluorescencia indirecta (IFI) como prueba de referencia para la detección de anticuerpos. Actualmente en Paraguay, el diagnóstico se basa en combinar dos pruebas serológicas. El objetivo del estudio fue evaluar la concordancia entre una prueba in-house de IFI y un test comercial de hemoaglutinación indirecta (HAI), para la detección de anticuerpos IgG anti-T. cruzi. Se evaluaron 54 muestras de pacientes que acudieron al Instituto de Investigaciones en Ciencias de la Salud (IICS) con solicitud médica de serología para Chagas. Los sueros fueron primeramente analizados por IFI (29 positivos y 25 negativos) y almacenados en una seroteca, posteriormente, se descongelaron para su análisis por HAI. Se determinó la concordancia entre IFI y HAI utilizando el índice Kappa. La concordancia observada entre ambos métodos fue muy buena (Índice Kappa=0,96; p(0,0001). No se observaron diferencias significativas en las frecuencias de muestras que presentaron IgG anti-T.cruzi en los niveles bajo (p=0,759), intermedio (p=1,000) y alto (p=0,592). Los anticuerpos medidos por ambos métodos mostraron buena correlación (Rho de Spearman= 0,715; p<0,01). La sensibilidad y especificidad de HAI frente a IFI fue 96,6% y 100%, respectivamente. Los hallazgos sugieren que la combinación de ambas pruebas evaluadas, o bien HAI con otras pruebas serológicas, sería una buena elección diagnóstica en la enfermedad de Chagas en nuestro medio.
Source of household water as main risk factor of soil-transmitted helminth infections among elementary school pupils in Wamena District, Jayawijaya Regency, Papua
Authors: Sandy Semuel , Kridningsih Tri Nury
Published: August 2023

BackgroundSoil-transmitted helminth (STH) infections are caused by three types of worms: Ascaris lumbricoides, Trichuris trichiura, and hookworms. Soil-transmitted helminth infections have significant health and socioeconomic implications for communities in developing countries, particularly in Indonesia. This study aims to determine the prevalence and risk factors of STH infections among elementary school pupils in Wamena District.
MethodsThe study design used was a cross-sectional design involving 317 elementary school pupils. The children were interviewed using a structured questionnaire that included demographic information, hygiene, and environmental sanitation data of the respondents. Stool samples were collected from all consenting participants in sterile plastic containers and were analyzed within 24 hours of collection, using the Kato-Katz method. The data were analyzed using bivariate statistical analysis (Chi-square) and multivariate analysis (logistic regression).
ResultsThe prevalence of helminthiasis among elementary school pupils was 19.9% (63/317). STH prevalence of mild category was 17.4% (55/317). The risk factors for STH infections among school children were the habit of not washing hands with soap after defecation, with an odds ratio of 5.04 [95% CI (2.22-11.48)], and the source of water for household use, with an odds ratio of 7.22 [95% CI (3.66-14.22)].
ConclusionThe prevalence of helminthiasis was found to be 19.9% (63/317), with an STH prevalence of mild category. Risk factors for STH infections included the habit of not washing hands with soap after defecation and the source of water for household use.
Attitudes toward fertility and childbearing among female University students
Authors: KOÇAK Derya Yüksel , Büyükkayacı Duman Nuriye , HOBEK AKARSU Rukiye
Published: August 2023

BACKGROUNDIn recent years, there has been a significant decrease in childbearing rates in many parts of the world. Young people who delay their marriage plans for various reasons also indirectly delay their childbearing to advanced ages. Postponed childbearing may lead to increased health risks for both mother and child. This study aimed to determine attitude towards fertility and childbearing in female university students.
METHODSThis cross-sectional study involved 259 female university students. The data were collected with Attitudes Toward Fertility and childbearing Scale (AFCS). Data were analyzed using t test and one-way ANOVA.
RESULTSIn the study 92.7% of the students wanted to become a future mother. The importance of fertility for the future mean score of the students with low income level (21.56±8.14) was found to be lower than the students with medium (25.80±6.51) and high income level (25.29±4.37) (p<0.05). The importance of fertility for the future mean score of only-child students (22.57±7.09) was lower than that of the other students (25.82±6.45). The importance of fertility for the future mean score of the students who did not have a date was also found to be lower than the students who had a date (p<0.05).
CONCLUSIONIn the study, students with a low income level, who are an only child and who do not have a date during the study care less about fertility for the future. Also, students with a single-parent family, with siblings, and no previous sexual intercourse identify childbearing more with female identity.
p53 gene mutations among patients involved with breast cancer: types of detection
Authors: Liu Mengyang , Wang Xia , Wu Jun , Li Peng
Published: August 2023

A significant transcription factor that is involved in the regulation of numerous cellular functions is the tumor suppressor p53. In disease, p53 weakens cell expansion in light of different boosts, including DNA harm, supplement hardship, hypoxia, and hyperproliferative signs, along these lines forestalling growth arrangement. It was detailed that the proficiency of Microarray and ABI 310 framework in distinguishing proof a wide range of p53 quality transformations. Microarray and ABI 310 analysis were used in this study to find p53 gene mutations in archived breast cancer tissues. Breast tissues from cancer patients who had been diagnosed with breast cancer were collected for this purpose and paraffin-embedded after being formalin-fixed. DNA was removed by the Microdissection technique and was cleaned with Microcon 50 channels (Millipore) prior to performing PCR. Twelve of the samples that were analyzed had ABI 310 system mutations in the p53 gene, the genomic DNA was acquired from micro-dissected tests without laser. The ABI 310 system identified p53 gene mutations in three of the nine ESCC specimens from patients who were examined by microarray. In laser-miniature analyzed examples changes were distinguished by ABI 310 framework. The extricated DNA obtained from laser miniature took apart examples was deficient for the evaluation of p53 quality changes with Microarray. It was resolved that Microarray was reliant upon how much tissues were utilized in DNA extraction. The resulting data of this study showed that selecting the appropriate method for extracting DNA from test samples in order to evaluate the p53 gene mutation is crucial. The ABI 310 system and Microarray were able to detect p53 gene mutations (for exons 5-8) with an efficiency of 99.6% and 27%, respectively. Consequently, involving new tissues for Microarray analysis is suggested. In conclusion, the application of Microarray to identify mutation for p53 gene, in breast cancer tissues, will be necessary for central hospitals, where fresh tissue samples are available easily.
Optimization procedure for conformance control
Authors: Fedorov Konstantin M. , Ganopolsky Rodion M. , Gilmanov Alexander Ya. , Shevelev Alexander P.
Published: August 2023

The article is devoted to the development of an optimization procedure for conformance control treatment. Currently, due to the significant share of reservoirs with high water cut, it is relevant to use methods that allow reducing the rate of production water cut increase. One of the most common methods to do this is to improve conformance by injecting suspension into the reservoir. The classical model of deep bed suspension migration has shown itself well for calculating the technological parameters of treatment, but it does not contain criteria for optimizing the process. The introduction of such criteria and their physical justification is the purpose of this work. The following objectives were set: modification of the classical model of deep bed suspension migration for layered strata, introduction of criteria of suspension treatment efficiency, and optimization of the process. Mathematical model consists of mass conservation laws and Darcy’s law. Initial data were selected for one of the fields in West Siberia, where suspension treatments were carried out to improve conformance. The field experience of these treatments is analyzed, the wells where the treatment was successful are determined. The new criterion for the effectiveness of suspension treatment is introduced. This criterion is the difference in the standard deviations of the flow rate along the layers before and after the treatment. It is established that this difference more clearly demonstrates the injectivity profile exchange than the classical Dykstra-Parsons criterion. The optimization procedure allows assessing the required slug volume that provides the maximum injectivity profile redistribution.
DYNAMICS OF AN ENERGY HARVESTER WITH HYSTERESIS FRICTION
Authors: Borzunov S. V. , Reshetova O. O.
Published: August 2023

A model of an energy harvester converter with hysteresis viscous friction is considered. The mechanical part of the energy harvester is made in the form of an inverted pendulum. The hysteresis is formalized within the framework of the Preisach model, which is a continuum analogue of a system of non-ideal relays connected in parallel. Within the framework of numerical experiments, the dependences of the dynamic parameters, in particular, the angle of deflection of the pendulum and the voltage on the load, as well as phase portraits, on the value of the coefficient characterizing the effect of hysteresis friction, were investigated. The role of nonlinear effects is demonstrated.
EQUIVARIANT PROPERTIES OF THE SPACE Z(X) FOR A STRATIFIABLE SPACE X
Authors: Zhuraev T. F. , Dolgopolov M. V.
Published: August 2023

In this paper, we prove the action of the compact group G defined by the stratified space X is continuous to the space Z(X) being a stratified space containing the self-stratified space X as a closed subset. An equivariant analogue of some results of R. Cauty concerning A(N)R(S) spaces is proved. It is presented that the orbit space Z(X)/G by the action of the group G is a S space.
Biosynthesis of Gold Nanoparticles by Aspergillus Niger And Their Role Against Pathogenic Bacteria
Authors: Alzamily Ihsan Ali , Al-Shibly Majid Kadhim , Hussein Ali Zaman Abdul
Published: August 2023

The study included the use of Aspergillus niger filtrate for the biosynthesis of gold nanoparticles (GNPs) using a reducing medium designed for this purpose. The synthesis of Nanoparticles was verified by means of detections by spectrophotometry, X-ray diffraction, FTIR, and scanning electron microscopy. Nanoparticles were used to inhibit pathogenic bacteria obtained from urinary infections patients, and they included Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus by poisoning the nutrient medium and drilling method. It was also verified that there are no toxins accompanying the biosynthesis of these nanoparticles by the ammonia method. The detections of characterization of GNPs confirmed that the particles were synthesized in spherical, oval, and crystalline shapes with sizes ranging from a few nanometers to 500 nanometers, and they gave a light absorption band at the wavelength of 520 nanometers. Concerning the effect of GNPs on pathogenic bacteria, the method of poisoning the media confirmed that the 15% concentration was significantly effective against the three bacterial species, as it gave the lowest diameter of colony growth (1.1, 1.6, 2.3) cm for Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus respectively. As for the drilling method, it also showed a high significant ability of 15% concentration to inhibit the tested bacteria by measuring the inhibition zone, which gave an area of ​​(5.1, 5.4,6) cm for Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus respectively, with regard to the toxicity test, the study showed that the isolate used in the synthesis does not produce toxins, which confirms its suitability and dependence in the biosynthesis of nanoparticles.
Anishinaabeg Elders’ Land-based Knowledge: Enacting Bagijigan for Health and Well-being
Authors: McGuire-Adams Tricia
Published: August 2023

Indigenous Elders carry knowledge systems that are embedded within their respective land-based systems of knowledge. When Indigenous Elders pass away, their knowledge systems, if not preserved and documented, also pass away, which has lasting impacts on the continuance of Indigenous knowledge and practices of health and well-being. As a result of the enduring presence of settler colonialism, Indigenous Elders pass away at far earlier ages in comparison to their non-Indigenous counterparts. This article shows the results of an Indigenous health and well-being research project led by an Anishinaabe community in partnership with an Anishinaabe researcher. Guided by Anishinaabeg Elders and a Community Advisory Board, this research project preserves and documents Elders' knowledge of the land for community use and asks, how does knowledge of the land inform our health and well-being practices? In this article, we argue that Elders' knowledge is integral for regenerating critical well-being practices. We demonstrate that placing Elders' knowledge at the forefront of our well-being is an actionable practice of ganandawisiwin or good health. Without such knowledge and practices, we risk missing an opportunity to learn about well-being practices from our most precious knowledge holders.
Comparing effectiveness and safety of paclitaxel plus raltitrexed vs. paclitaxel alone in second-line palliative chemotherapy for metastatic gastric adenocarcinoma: A randomized phase II clinical trial
Authors: Zhao Xiaoying , Chen Zhiyu , Zhang Xiaowei , Zhu Xiaodong , Zhang Wen , Qiu Lixin , Wang Chenchen , Huang Mingzhu , Zhang Zhe , Li Wenhua , Yang Lei , Guo Weijian
Published: August 2023

Objective: Paclitaxel (P) is a standard second-line chemotherapy in the treatment of advanced gastric cancer. This study compared the clinical outcome of a paclitaxel plus raltitrexed (RP) regimen as second-line treatment in metastatic gastric cancer (MGC) patients. Methods: An open, randomized, multi-center phase II clinical trial was conducted involving 148 patients who were randomly assigned and treated with RP [raltitrexed (3 mg/m2 on day 1) and paclitaxel (135 mg/m2 on day 1 every 3 weeks)] or P [paclitaxel (135 mg/m2 on day 1 every 3 weeks)] as 2nd-line chemotherapy. The primary endpoint was progression-free survival (PFS). The secondary endpoints were the overall response rate (ORR), overall survival (OS), and safety. Results: PFS had a tendency to be prolonged with RP compared to P (2.7 months vs. 1.7 months; P = 0.148). OS was also prolonged with RP compared to P (10.2 months vs. 6.1 months; P = 0.140). The ORR was equal in the RP and P groups (6.8% and 4.0%; P = 0.72). The disease control rate (DCR) in the RP and P groups was 56.2% and 36.0%, respectively. Grade 3-4 treatment-related adverse events occurred in 36.2% (RP) and 28.2% (P) of patients. Frequent grade 3-4 toxicities for RP and P were neutropenia (11.0% and 4.0%), anemia (1.4% and 4.0%), and thrombocytopenia (1.4% and 5.3%), and all grades of peripheral neurotoxicity (12.3% vs. 17.3%). All grades of hepatic toxicity were demonstrated for the RP and P groups based on elevated aminotransferase levels (27.4% and 14.1%). Subgroup analysis shows if MGC was combined with ascites or peritoneal involvement, the OS of the RP regimen was longer (P = 0.05). Conclusions: Second-line palliative chemotherapy with RP was shown to prolong the PFS and OS, especially among patients with ascites or peritoneal involvement, which warrants confirmation using larger sample studies.
Untousling the Role of Tousled like Kinase 1 in DNA Damage Repair
Authors: Ghosh Ishita , De benedetti Arrigo
Published: August 2023

DNA damage repair lies at the core of all cells’ survival strategy, including cancerous. Therefore, targeting such repair mechanisms forms the major goal of cancer therapeutics. The mechanism of DNA repair has been tousled with the discovery of multiple kinases. Recent studies on Tousled like Kinases have brought significant clarity on the effectors of these kinases which stands to regulate DSB repair. In addition to their well-established role in the DDR and cell cycle checkpoint mediation after DNA damage or inhibitors of replication, their suspected involvement in the actual DSB repair process has more recently been strengthened by the important finding that TLK1 phosphorylates RAD54 and regulates some of its activities and localization in the cell. Earlier findings of its regulation of RAD9 during checkpoint deactivation as well as defined steps during NHEJ ends processing were earlier hints of its important involvement broadly in DSB repair. All this has opened up new avenues to target cancer cells in combination therapy with genotoxins and TLK inhibitors.
Antitumor Effect of Epigallocatechin Gallate and Vincristine in Mice with L5178Y Lymphomae
Authors: Almaguer Georgina , Almaguer-Vargas Gustavo , Molina Eva Maria , Becerril Marco Antonio , Montejano Brenda , Madrigal Eduardo Osiris , Hernandez Alejandra , Figueroa Ana Hilda , Montejano Ethoan , Montejano José Ramón
Published: August 2023

The search for more efficacy and fewer toxic effects in cancer treatments is the main objective of research into new therapies. Vincristine (VCR) is a chemotherapeutic used in different types of tumors. Epigallocatechin gallate (EGCG) is a green tea metabolite that has shown an antineoplastic effect in different investigations, so the objective of this work was to evaluate the antitumor effect of the EGCG/VCR combination on tumor volume and survival. To achieve this objective, the solid model of lymphoma L5178Y was used in BALB/c mice with different doses of VCR, EGCG and their combination; Tumor grow and survival time were recorded. Once the tumors were obtained, they were measured and immunohistochemistry was performed for p53, Bcl2 and CD1. The results showed that the EGCG/vincristine combination had a greater antitumor effect that vincristine and EGCG. This can be partly attributed to the fact that the greatest Bcl2 inhibition was present in the combination of EGCG with vincristine. Therefore, it can be concluded that the combination of EGCG with vincristine has a better antineoplastic effect by inhibiting tumor development and increasing survival than both substances independently.
A Novel Predictive Machine Learning Model Integrating Cytokines in Cervical-Vaginal Mucus Increases the Prediction Rate for Preterm Birth
Authors: Borboa-Olivares Hector , Rodríguez-Sibaja Maria Jose , Espejel-Nuñez Aurora , Flores-Pliego Arturo , Mendoza-Ortega Jonatan , González-Camarena Ramón , Echeverría-Arjonilla Juan Carlos , Estrada-Gutierrez Guadalupe
Published: August 2023

Preterm birth (PB) is a leading cause of perinatal morbidity and mortality. PB prediction is per-formed by measuring cervical length, with a detection rate of around 70%. Although it is known that a cytokine-mediated inflammatory process is involved in the pathophysiology of PB, no screening method implemented in clinical practice includes cytokine levels as a predictor varia-ble. Here, we quantified cytokines in cervical-vaginal mucus of pregnant women (18-23.6 weeks of gestation) with high- or low-risk for PB determined by cervical length, collecting relevant obstetric information. IL-2, IL-6, IFN-γ, IL-4, and IL-10 were significantly higher in the high-risk group, while IL-1ra was lower. Two different models for PB prediction were created using the Random Forest machine-learning algorithm: the full model with 12 clinical variables and cyto-kine values, and the adjusted model, including the most significant variables -maternal age, IL-2, and cervical length- (detection rate 66 vs 87%, false positive rate 12 vs 3.33%, false negative rate 28 vs 6.66%, and area under the curve 0.722 vs 0.875, respectively). The adjusted model integrat-ing cytokines showed a detection rate 8 points higher than the gold standard calculator, which may allow us to identify PB risk more accurately and implement strategies for preventive in-terventions
Validating the Use of Mixed Reality in Industrial Quality Control: A Case Study
Authors: Silva José , Coelho Pedro , Saraiva Luzia , Vaz Paulo , Martins Pedro , Henriques João
Published: August 2023

Quality control is a critical component in industrial manufacturing, directly influencing efficiency, product reliability, and ultimately, customer satisfaction. In the dynamic environment of industrial manufacturing, traditional methods of inspection may not adequately meet the evolving complexity, necessitating innovative approaches to bolster precision and productivity.
In this study, we explore the application of mixed reality (MR) technology for real-time quality control in the assembly process. Our methodology involved the integration of smart glasses with a server-based image recognition system, designed to conduct real-time component analysis. The innovative aspect of our study lies in the harmonization of MR and computer vision algorithms, providing immediate visual feedback to inspectors and thereby improving the speed and accuracy of defect detection.
YOLOv8 have been adopted in this study for detection object model.
The project implementation occurred in a controlled environment to enable a comprehensive evaluation of the system functionality, the identification of possible problems and improvements in the system performance.
The results indicated the viability of mixed reality as a powerful tool for enhancing traditional inspection processes. The fusion of MR and computer vision offers possibilities for future advancements in industrial quality control, paving the way for more efficient and reliable manufacturing ecosystems.
Visualisation of Fossilised Tree Trunks Using Immersive 3D-360 Audio-Visual and Geospatial Digitisation Techniques in XR Derived from UAS and Terrestrial Data, Aided by Machine Learning Computational Photography
Authors: Psarros Charalampos , Zouros Nikolaos , Soulakellis Nikolaos
Published: August 2023

The aim of this research is to investigate and use a variety of immersive multisensory media techniques in order to create convincing digital models of fossilised tree trunks for use in XR. This is made possible via the use of geospatial data derived from sources such as aerial imaging using UAS, terrestrial material using cameras and also include both the visual and audio element for better immersion, accessible and explorable in 6 Degrees of Freedom (6DoF). Immersiveness is a key factor in order to result in output that is especially engaging to the user. Both conventional and alternative methods are explored and compared, emphasising in the advantages made possible via the help of Machine Learning Computational Photography. Material is collected using both UAS and terrestrial camera devices, including a 3D-360º camera with 6 sensors, using stitched panoramas as sources for photogrammetry processing. Difficulties such as capturing large free standing objects using terrestrial means were overcome using practical solutions involving mounts and remote streaming solutions. Conclusions indicated that superior fidelity can be achieved by the help of Machine Learning Computational Photography processes and higher resolutions and technical specs of equipment not necessarily translating to superior outputs.
Implementation of Sustainable Development Goal 11 (Sustainable Cities and Communities): Initial Good Practices Data
Authors: Nabiyeva Gulnara N. , Wheeler Stephen M. , London Jonathan K. , Brazil Noli
Published: August 2023

The Sustainable Development Goals (SDGs) represent a central framework to guide sustainable urban development (2030 Agenda). However, it is not clear how and where SDG 11 (Sustainable Cities and Communities) is being implemented, and how such implementation might be improved. We investigated this subject by analyzing United Nations (UN) SDG Good Practices data from 2018 to 2021. We applied five criteria to the 336 SDG 11 responses: (1) geography; (2) actors; (3) progress toward targets; (4) areas of implementation; and (5) scale of action. Overall, 86 of the 193 countries that adopted the 2030 Agenda submitted at least one SDG 11 good practice. 33 countries contributed 73.8% of the total, and most developing countries did not make submissions. A very small number of responses (between 2.6 and 9.1%) addressed equity-related targets. Good practices from developed countries were usually more technology-based and system-forming; developing countries typically focused on issues of day-to-day concern. Overall, this analysis points to the need for better and more systematic reporting on SDG 11 implementation, a more active public sector role in SDG implementation and reporting, more focus on dimensions related to social equity, and better formulation of urban sustainability targets and indicators in the future.
Shared Autonomous Vehicles as Last Mile Public Transport of Multimodal Train Trips
Authors: Liu Zhiwei , Liu Jianrong
Published: August 2023

The accessibility of public transportation is also known as the last mile problem, and it is one of the main obstacles that affect travelers to choose public transport. Although autonomous vehicles (AVs) have made much progress, they have not been officially put into commercial use. This paper adopts stated preference experiments to explore the impact of shared AVs on train trips’ last-mile travel behavior and takes Wuhan as an example for case analysis. First of all, this paper establishes a structural equation model (SEM) based on the theory of planned behavior to explore the latent psychological variables, including travelers’ attitudes (ATTs), subjective norms (SNs), perceived behavior control (PBC), and behavioral intention to use (BIU) toward AVs. These latent psychological variables are incorporated into the latent class (LC) logit model to establish a hybrid model to study the factors and degree of influence on the travel mode choice for the last mile of train trips. The results show that travelers have preference heterogeneity for the travel mode choice of the last mile of train trips. Through the analysis of LCs, education, career, and income significantly impact the classification of LCs. The latent psychological variables towards AVs have a significant impact on the travel behavior of respondents, but the impacts vary among different segments. Elastic analysis results illustrate that a 1% increase in the travel cost for shared AV in segment 1 leads to a 7.598% decrease in the choice probability of shared AV. Respondents from different segments vary significantly in their willingness to pay, and the value of travel time for high-income groups is relatively higher.
Caloric Effect Due to the Aharonov-Bohm Flux in an Antidot
Authors: Martínez-Rojas Patricia , Benavides-Vergara M. , Peña Francisco J. , Vargas Patricio
Published: August 2023

In this work, we report the caloric effect for an electronic system of the antidot type, modeled by combining a repulsive and attractive potential (parabolic confinement). In this system, we consider the action of a perpendicular external magnetic field and the possibility of having an Aharonov-Bohm flux (AB-flux) generated by a current passing through a solenoid placed inside the forbidden zone for the electron. The energy levels are obtained analytically, and the model is known as the Bogachek and Landman model. We propose to control the caloric response of the system by varying only the AB-flux, finding that in the absence of an external magnetic field, the maximization of the effect always occurs at the same AB-flux intensity independent of the temperature while fixing the external magnetic field at a non-zero value breaks this symmetry and changes the point where the caloric phenomenon is maximized and is different depending on the temperature to which the process is carried. Due to the great diversity in technological applications that have antidots in electronics, the possibility of controlling their thermal response just by varying the intensity of the internal current inside the solenoid can be a platform of interest for experimental studies.
Computer Aided Full Arch Restoration by Means of One-Piece Implants and Stackable Guide: A Technical Note
Authors: Manfredini Mattia , Poli Pier Paolo , Maiorana Carlo , Salina Federica Eugenia , Tandurella Marco , Beretta Mario
Published: August 2023

A maxillary totally edentulism was rehabilitated with one-piece implants starting from pre-existing totally removable denture. A 3D digital scan of the removable denture and upper and lower arches was performed. On this basis, a prototype with optimal esthetic and functional outcomes was re-alized and turned into a custom-made radiological stent with markers. The superimposition of STL and DICOM files allowed the virtual planning of one-piece implants ideal position. The stackable templates composed of a fixed component, namely base template, and removable components, were realized. The fixed component, once secured with anchor pins to the bone, was no longer removed. The removable components, screwed to the fixed component, were used to perform the implant surgery and the immediate prosthetic loading. A base template allowed for maintaining a fixed reference during the entire workflow, improving the transition between the digital project, the surgical procedure, and the prosthetic rehabilitation.
Geometrical Selection of GaN Nanowires Grown by Plasma-Assisted MBE on Polycrystalline ZrN Layers
Authors: Olszewski Karol , Sobanska Marta , Dubrovskii Vladimir G. , Leshchenko Egor D. , Wierzbicka Aleksandra , Zytkiewicz Zbigniew R.
Published: August 2023

GaN nanowires grown on metal substrates attract an increasing interest for a wide range of applications. Herein, we report GaN nanowires grown by plasma-assisted molecular beam epitaxy on thin polycrystalline ZrN buffer layers, sputtered onto Si(111) substrates. The nanowire orientation is studied experimentally and described within a model as a function of the Ga beam angle, nanowire tilt angle and substrate rotation. We show that vertically aligned nanowires grow faster than inclined nanowires, which leads to an interesting effect of geometrical selection of the nanowire orientation in the directional molecular beam epitaxy technique. After a given growth time, this effect depends on the nanowire surface density. At low density, the nanowires continue to grow with random orientations as nucleated. At high density, the effect of preferential growth induced by unidirectional supply of material in MBE starts to dominate. Faster growing nanowires with smaller tilt angles shadow more inclined nanowires that grow slower. This helps to obtain more regular ensembles of vertically oriented GaN nanowires despite their random position induced by the metallic grains at nucleation. The obtained dense ensembles of vertically aligned GaN nanowires on ZrN/Si(111) surfaces are highly relevant for device applications. These results are not specific for GaN nanowires and should be relevant for any nanowires which are epitaxially linked to the randomly oriented surface grains in the directional molecular beam epitaxy.
Biocompatible Anisole-Nonlinear PEG core-shell Nanogels for High Loading Capacity, Excellent Stability, and Controlled Release of Curcumin
Authors: Shen Jing , Zhang Jiangtao , Wu Weitai , Banerjee Probal , Zhou Shuiqin
Published: August 2023

Curcumin, a nontoxic and cheap natural medicine, has high therapeutic efficacy for many diseases including diabetes and cancers. Unfortunately, its exceedingly low water-solubility and rapid degradation in the body severely limit its bioavailability. In this work, we prepare a series of biocompatible poly(vinyl anisole)@nonlinear poly(ethylene glycol) (PVAS@PEG) core-shell nanogels with different PEG gel shell thickness to provide high water solubility, good stability, and controllable sustained release of curcumin. The PVAS nanogel core is designed to attract and store curcumin molecules for high drug loading capacity and the hydrophilic nonlinear PEG gel shell is designed to offer water dispersibility and thermo-responsive drug release. The obtained nanogels are monodispersed in spherical shape with clear core-shell morphology. The size and shell thickness of the nanogels can be easily controlled by changing the core-shell precursor feeding ratios. The optimized PVAS@PEG nanogels display a high curcumin loading capacity of 38.0 wt%. The nanogels can stabilize the curcumin from degradation at pH =7.4 and release the curcumin in response to heat in the physiologically important temperature range. The nanogels can enter cells effectively and exhibit negligible cytotoxicity to both the B16F10 and HL-7702 cells at a concentration up to 2.3 mg/mL. Such designed PVAS@PEG nanogels have a great potential to be used for delicate drug delivery.