bluuebunny/crossref_metadata_2025 huggingface dataset:
Subacute Lupus erythematosus-like Gyrate Erythema
Authors: Neumann R. , Schmidt J.B. , Niebauer G.
Published: October 2009

We present a case of an annular skin lesion in association with a breast cancer. For differential diagnosis we had to consider subacute cutaneous lupus erythematosus and the group of gyrate erythemas. Lupus band test and immune serology were negative. The parallel course of the erythema and the internal malignancy were striking.
Triple Extramammary Paget’s Disease
Authors: Hashimoto T. , Inamoto N. , Nakamura K.
Published: October 2009

A 75-year-old man developed three lesions of Paget’s disease which involved the pubic area and both axillae. Histologically, there was no invasion into the dermis in any of the three lesions. Various kinds of histochemical and immunohistochemical studies including those for carcinoembryonic antigen showed that both genital and axillary lesions were identical in nature. Cases with triple involvement of Paget’s disease are thought to be extremely rare in the literature.
Acute Generalized Exanthematous Pustular Dermatitis and Viral Infection
Authors: Rouchouse B. , Bonnefoy M. , Pallot B. , Jacquelin L. , Dimoux-Dime G. , Claudy A.L.
Published: October 2009

Three patients with acute generalized exanthematous pustular dermatitis (AGEPD) are presented. This new clinical entity comprises generalized erythema, erythema multiforme, amicrobial pustules, fever and spontaneous healing over a 10-day period. Histologically, there are a mixed neutrophilic and eosinophilic vasculitis and an eosinophilic subcorneal and spongiform pustule. All the patients experienced pharyngitis 1 week before the onset of the rash. Two of them had high-titered IgM-neutralizing antibodies to enteroviruses and 1 had an enterovirus in stool and urine. AGEPD may be related to a viral infection and may occur in patients with a genetic predisposition to psoriasis. The diagnosis of AGEPD should be made early enough so that the patients are not given the often aggressive therapy of pustular psoriasis.
Prurigo pigmentosa: 3rd Non-Japanese Case
Authors: Harms M. , Mérot Y. , Polla L. , Saurat J.-H.
Published: October 2009

A 23-year-old woman suffering since 4 years from Prurigo pigmentosa is presented. Histology from an early lesion shows neutrophilic infiltration of epidermis and dermis. Treatment with Dapsone and potassium iodide was effective but failed to prevent recurrences.
Isotretinoin versus Minocycline in Cystic Acne: A Study of Lipid Metabolism
Authors: Pigatto P.D. , Finzi A.F. , Altomare G.F. , Polenghi M.M. , Vergani C. , Vigotti G.
Published: October 2009

We have recently reported that patients with severe nodular cystic acne have much lower levels of HDL-cholesterol, apolipoprotein A and hepatic lipoprotein lipase than healthy controls or subjects with acne vulgaris. Since isotretinoin is very effective in the treatment of the nodular cystic acne but has been shown to increase blood lipid levels, we decided to compare its clinical effectiveness and its effects on lipid metabolism with those of minocycline in patients with nodular cystic acne. After 20 weeks, the number and mean diameter of the cysts were definitely decreased in both groups, but the improvement was more striking in the isotretinoin-treated group. At the end of the treatment, the HDL-C and hepatic lipoprotein lipase levels in this group were increased toward normal, but not in the minocycline-treated group. Our study showed a significant remission in the acne of patients treated with isotretinoin but not in that of the minocycline-treated patients. Furthermore isotretinoin can also correct the altered lipid metabolism in these patients.
Dermatomyositis Associated with Idiopathic Thrombocytopenia
Authors: Cooper C. , Fairris G. , Cotton D.W.K. , Steart P. , Barth J.H.
Published: October 2009

A case of dermatomyositis is described with the simultaneous appearance of clinical and laboratory features of myositis, skin involvement and idiopathic thrombocytopenia with associated anti-platelet antibodies.
Skin Lesions in Sadomasochism
Authors: Sønderbo Karin , Nyfors Allan
Published: October 2009

This paper presents the case of a 35-year-old man who consulted the department of venereology because of healing problems with some wounds caused by burning his skin perianally with cigarettes as part of a sexual satisfaction ritual. Knowledge of such lesions may be useful to physicians and social workers. Sadomasochism and ‘Offers’ in the intimate-massage clinics in Copenhagen are surveyed.
Oral Gold Therapy (Auranofin) in Pemphigus vulgaris
Authors: Salomon Denis , Saurat Jean-Hilaire
Published: October 2009

Auranofin (AF), an oral gold salt, was given for 9–18 months to 3 patients with pemphigus vulgaris. There was a slight improvement with significant oral pain relief in 2, and a complete remission in 1. Two patients including the one with the remission, subsequently flared up under AF therapy. Although AF is said to be better tolerated than parenteral gold this limited series suggests that it does not seem to have a superior therapeutic effect in PV.
Contact Sensitivity in Children and Adults with Atopic Dermatitis – A Chronological Study
Authors: Lisi P. , Simonetti S.
Published: October 2009

61 atopic dermatitis patients were subjected to a second patch testing 3–15 years (average 7.3 years) after the first contact sensitivity examination. The comparison between the results of the two studies revealed that 26.2% of patients had been sensitive to one or more haptens at the first patch testing and that 24.6% reacted positively at the second. 9 subjects (14.8%) still manifest contact sensitivity, while 6 (9.8%) reversed to positivity and 7 (11.5%) to negativity. The chemicals most frequently involved were nickel sulphate, potassium dichromate, benzoyl peroxide, diphenylguanidine. This study demonstrates that contact reactions are not linked to susceptibility to skin irritants in atopic dermatitis patients and that they tend to increase with time.
Non-Organ-Specific Autoimmunity in Alopecia
Authors: Zauli D. , Veronesi S. , Fusconi M. , Lama L. , Melino M. , Tosti A. , Bianchi F.B.
Published: October 2009

A significantly high prevalence (41%) of non-organ-specific autoantibodies, tested in immunofluorescence with sera diluted 1:40, is reported in sera from 86 alopecia patients. No correlation was found with extension and duration of the disease, topical treatment with contact agents or response to it. The relevance and significance of these findings, with particular reference to anti-smooth muscle and anti-basal cell layer antibodies, is discussed.
Sweet’s Syndrome and Toxoplasmosis: A Coincidental Association?
Authors: Delfino Mario , Suppa Francesco , De Luca Francesco , Lembo Giuseppe
Published: October 2009

A case report of febrile neutrophilic dermatosis as previously described by Sweet. The acute febrile illness is accompanied by plaque eruption and a positive toxoplasma indirect fluorescent antibody (IFA) test. Moreover, clinical and histopathological manifestations were compatible with the cutaneous reactive manifestation of toxoplasmosis and disappeared only after specific therapy.
Multiple Eruptive Verrucous Hemangiomas: A Variant of Multiple Hemangiomatosis
Authors: Cruces M.J. , De la Torre C.
Published: October 2009

We present a case of an 8-year-old girl, who has, since birth, developed multiple angiomatous lesions of the skin. The evolution has been progressive and eruptive, with the lesions, beginning as reddish papulae, acquiring later a verrucous appearance. The case has revealed no associated systemic symptoms nor relevant family history of any interest. The clinical picture suggests multiple hemangiomatosis. The histopathology seems to relate this disorder to verrucous hemangioma, and therefore needs to be differentiated from angiokeratotic nevi. To our knowledge, reports of a similar clinicopathological picture are not mentioned in the literature.
Bullous Pemphigoid, Figurate Erythema and Generalized Pigmentation with Skin Thickening in a Patient with Adenocarcinoma of the Stomach
Authors: Urano-Suehisa Shoko , Tagami Hachiro , Yamada Mizuho , Hishiki Shuji , Tokura Yasuyuki
Published: October 2009

A 52-year-old woman with bullous pemphigoid developed a bizarre figurate erythematous eruption and generalized pigmentation and velvety skin thickening. Later on, these cutaneous signs were found to be associated with an underlying adenocarcinoma of the stomach. Double-diffusion precipitation and indirect immunofluorescence, however, failed to demonstrate circulating antibodies against the tumor tissue in our patient.
Neoplastic Proliferation in a Case of Epidermotropic High-Grade Malignant Lymphoma Associated with Hypercalcemia
Authors: Pierard G.E. , Pierard-Franchimont C. , Le T.
Published: October 2009

We report a case of epidermotropic high-grade malignant lymphoma associated with hypercalcemia occurring in a European woman aged 30 years. The clinical, histological, and biological presentation of the patient could enter the spectrum of HOTS (hypercalcemia, osteolysis, Tcell lymphoma syndrome). The proliferation of neoplastic lymphocytes was very high in patch, plaques, and nodules of the skin.
Ichtyose linéaire circonflexe de Comèl: traitement par Ro 10-9359
Authors: Mathys C. , De Dobbeleer G. , Ledoux M. , Achten G.
Published: October 2009

The authors show the noteworthy efficacy of the aromatic retinoid Ro 10-9359 in the treatment of ichthyosis linearis circumflexa. The initial dose was 1 mg/kg daily; later on, the maintenance dose was 0.3 mg/kg daily. Ultrastructurally, transitional cells were observed between the granular and the horny layer. After treatment, large perinuclear pseudovacuoles appeared, as well as numerous microvilli.
Identification of HLA Antigens in Familial and Non-Familial Epidermodysplasia verruciformis
Authors: Wojtulewicz-Kurkus Jadwiga , Gliński Wiesław , Jabłońska Stefania , Podobińska Iwona , Obałek Sławomir
Published: October 2009

The distribution of HLA specificities was studied in 7 non-familial cases of epidermodysplasia verruciformis (EV) and in 5 cases from one family. In the non-familial cases, six antigens of locus A (2, 3, 9, 10, 24, 26) and eight antigens of locus B (7, 15, 27, 35, 37, 38, 40, 41) were found. All 5 cases of familial EV possessed 26,5 haplotype, however, 6 of the remaining 12 healthy family members inherited the same haplotype. There is no association of EV with HLA-A and B antigens. However, the defect of cell-mediated immunity, present in all EV cases, may indicate the association of the disease with other major histocompatibility products (i.e. loci on immune response genes).
Ocular Abnormalities Occurring with Alopecia areata
Authors: Tosti A. , Colombati S. , Caponeri G.M. , Ciliberti C. , Tosti G. , Bosi M. , Veronesei S.
Published: October 2009

This study was carried out on 83 patients with alopecia areata. Ophthalmological examinations showed lens changes in 65 patients and alterations in the retinal epithelium in 28 patients. The relationships between pigment cells and hair cycle are discussed.
Photosensitivity Associated with Carprofen (Imadyl®)
Authors: Goh C.L. , Kwok S.F.
Published: October 2009

Photodermatitis from Carprofen in 3 patients was reported. The absorbance spectrum of Carprofen revealed maximum absorbance at UVB range. The clinical presentation in the 3 patients suggested that a phototoxic mechanism may be responsible.
Dyshidrosiform Pemphigoid
Authors: Rongioletti F. , Parodi A. , Rebora A.
Published: October 2009

A case of localized pemphigoid simulating dyshidrosis is described. Only direct immunofluorescence permitted a correct diagnosis.
Multiple Sclerosis and Bullous Pemphigoid
Authors: Simjee Salma , Konqui Alain , Ahmed Razzaque
Published: October 2009

3 patients with multiple sclerosis (MS) who developed severe widespread bullous pemphigoid (BP) are presented. MS preceded the presentation of BP by 13–23 years (mean 18 years). BP was confirmed histologically and immunopathologically. Upon successful therapy with steroids, no recurrence of BP was observed over a 3–5 year (mean 3.7 years) follow-up. Several abnormalities of the immune system have been reported in both diseases. It is interesting to speculate that amidst existing immunologic abnormalities in all 3 patients with MS, a specific event, immunologic or viral or both may have triggered the development of BP.
Cutaneous Leiomyoma of the Male Nipple
Authors: Tsujioka K. , Kashihara M. , Imamura S.
Published: October 2009

A case of cutaneous leiomyoma of the male nipple is reported. This is the second case reported by dermatologists to the best of our knowledge.
Les compartiments conjonctifs dans les sclérodermies
Authors: Pierard G.E. , Pierard-Franchimont C. , Lapière C.M.
Published: October 2009

A combined histological and biomechanical study was performed in patients with localised or systemic scleroderma. The inflammatory reaction was variable in intensity and location, predominating around the superficial vascular plexus, the deep dermo-hypodermal plexus, the paraseptal plexus or in the fasciae. Secondary sclerosis resulted from the lateral fusion of bundles of collagen fibers. Three degrees of intensity of sclerosis were disclosed by our noninvasive technique of tonometry by vertical traction of the skin in vivo. That measurement allowed a follow-up of the evolution of the disease and a control of the therapeutic efficacy.
Occurrence of Cicatricial Pemphigoid and Leiomyosarcoma in a Psoriatic Patient
Authors: David M. , Oren N. , Feuerman E.J.
Published: October 2009

A psoriatic patient who developed cicatricial pemphigoid and leiomyosarcoma of the abdomen is presented. The sequence of events indicates a relationship between the cicatricial pemphigoid and the malignant disease.
Raynaud’s Phenomenon with Oral Manifestation in Systemic Lupus erythematosus
Authors: da Cunha Bang Flemming , Lange Wantzin Gunhild , Dahl Christensen Jens
Published: October 2009

A 24-year-old woman with discoid lupus erythematosus developed systemic lupus erythematosus after 6 years. One of the clinical features was Raynaud’s phenomenon in the fingers and toes, and furthermore Raynaud’s phenomenon appeared in the tongue when exposed to cold and windy weather.
Urticaria pigmentosa Treated with Oral Disodium Cromoglycate
Authors: Lindskov Rune , Wantzin Gunhild Lange , Knudsen Lone , Søndergaard Ib
Published: October 2009

4 patients with urticaria pigmentosa were treated with oral disodium cromoglycate (DSCG) for 2 months. During the treatment urine excretion of the main histamine metabolite, 1,4-methylimidazoleacetic acid (MIAA), was determined, and sequential skin biopsies were examined. DSCG was found to have beneficial effect on pruritus and whealing in 3 patients. The one treatment failure was in a patient without pruritus. The skin lesions remained unchanged. DSCG treatment had no efect on MIAA excretion or on the number of mast cells found in the skin biopsies.
A Newly Recognized Feature of Ectrodactyly, Ectodermal Dysplasia, Clefting (EEC) Syndrome: Comedone naevus
Authors: Leibowitz M.R. , Jenkins T.
Published: October 2009

A 21-year-old Black South African man with clinical features of ectrodactyly, ectodermal dysplasia, cleft lip/palate (EEC) syndrome is described. The patient had the following anomalies: hypoplastic, peg-shaped teeth; fine, silky hair; absent lacrimal puncta resulting in secondary photophobia, blepharitis and corneal opacities. The hands and feet showed absent digits, symphalangism and displacement of bone consistent with ectrodactyly. In addition, the patient had extensive comedone naevus, a feature not previously reported in EEC syndrome. We stress that the dysplastic ectodermal features of EEC syndrome are not typical of either hidrotic or anhidrotic ectodermal dysplasia but fall into a class of their own. Clefting of the lip and palate were absent due, it is postulated, to the variable expressivity of EEC syndrome.
Pseudomegadactyly
Authors: Mittal R.L. , Mittal R.
Published: October 2009

An interesting case of chronic paronychia of the big toe for the last 6 years resulting in granulomatous reaction and hypertrophy of nail plate and bed is being reported. An increased rate of longitudinal growth of nails may occur in association with infection around the nail, in bullous, ichthyosiform erythroderma and in psoriasis as already reported, but a unique feature in this patient was the increase in size of the nail plate in all directions, along with simultaneous increase in the surface area of the nail bed.
Malignant Melanoma Associated with Mycosis fungoides
Authors: Flindt-Hansen Henrik , Brandrup Flemming
Published: October 2009

2 cases of malignant melanoma in 2 male patients, 68 and 63 years old, associated with mycosis fungoides and parapsoriasis en plaques, respectively, are reported. The parapsoriasis later on developed into mycosis fungoides. A pathogenetic linkage based on decreased cellular immunity in mycosis fungoides is suggested.
An Epidemic Study of Molluscum contagiosum
Authors: Niizeki Kanji , Kano Otsuhei , Kondo Yoshiro
Published: October 2009

The incidence of molluscum contagiosum (MC) in children attending 15 public elementary schools and 9 kindergartens in Chigasaki City was studied by questioning their parents. Special attention was paid to the relationship between MC and swimming, and the incidence of MC in the swimming group was twice as high as that of the nonswimming group. This study also revealed that the predilection for lesions was the side of the trunk and the axillae.
Monoclonal IgG Immunoglobulinemia with Subsequent Myeloma in Psoriatic Arthritis
Authors: Peltonen Leena , Nikoskelainen Eeva , Kätkä Kalevi , Tyrkkö Juhani
Published: October 2009

A 42-year-old man had suffered from skin psoriasis for 27 years, psoriasis arthritis for 6 years and corneal crystalline deposits for 1 year, when an IgG-kappa monoclonal immunoglobulin was detected in his serum electrophoretic pattern. All the diagnostic studies for multiple myeloma were negative. However, 16 months later he developed this disease.
Multicentric Reticulohistiocytosis
Authors: Guillen Carlos , Fortea Jose M. , Serrano Gabriel , Martorell Miguel A. , Cogollos Emilio , Alegre Victor , Aliaga Adolfo
Published: October 2009

A case of multicentric reticulohistiocytosis in a 49-year-old man associated with polymyositis is presented. The clinical features along with the light and electron microscopic studies are commented. Partial improvement of the skin lesions was achieved after treatment with azathioprine but the patient’s general condition remained unchanged.
T Cell Subsets and Macrophages in Lichen planus
Authors: Buechner S.A.
Published: October 2009

Skin lesions from 6 patients with lichen planus were studied for the presence of T cells and T cell subsets using monoclonal antibodies and indirect immunoperoxidase technique. Small numbers of Leu-2a-reactive suppressor-cytotoxic cells were present early in the basal cell layer in 2 patients with recent lesions. The analysis of T cell subsets revealed the predominance of anti-pan-T-cell (Leu-1)- and Leu-3a-reactive helper-inducer cells in 4 patients with older active lichen planus lesions. Significant numbers of suppressor-cytotoxic cells were observed in the papillary dermis and within the epidermis associated with hydropic degeneration of the basal cell layer. Activated T lymphocytes with focal acid phosphatase activity, together with activated histiocytes-macrophages with strong diffuse activity of acid phosphatase and non-specific esterase, were identified in the dermis and within the epidermis. These findings suggest that a cytotoxic immune process directed against the basal cell layer of the epidermis is the dominant pathogenic event in lichen planus.
Characterization of Cellular Infiltrates in Skin Lesions of Atopic Eczema by Means of Monoclonal Antibodies
Authors: Rocha C. , de Maubeuge Josianne , Sarfati Marie , Song Micheline , Delespesse G.
Published: October 2009

Frozen skin biopsies from 3 acute and 3 chronic lesions of atopic dermatitis were examined by means of various ortho-monoclonal antibodies (OKT3,4 ] = C4, OKT6, OKT8; OKIa and OKM1) in an indirect immunofluorescence technique. The results show that both T helper (T4) and T suppressor cytotoxic (T8) lymphocytes are present in the inflammatory infiltration which predominantly contained la mononuclear cells. Despite the absence of double staining procedure, the observations suggest that T4 cells predominate over T8 cells in the acute lesions whereas the reverse tendency is noted in the chronic lesions. T8 cells are found mainly in the superficial dermis or even in the epidermis; by contrast, T4 cells tend to be more deeply located in the dermis. The lesions are characterized by a dramatic increase in the number of Langerhans cells (OKT6, OKIa+) that are found not only in the epidermis but also in the dermis.
Autoantibodies to Epithelial Cells (Intercellular Substance) and Their Correlation with Clinical Activity of Pemphigus vulgaris
Authors: Golan D. , Gilhar A. , Shmuel Z. , Moshkowitz M.
Published: October 2009

The presence of autoantibodies to intercellular substance of squamous epithelium was studied in the sera of 46 patients suffering from pemphigus vulgaris. This study suggests that in the majority of patients suffering from the severe form of the disease the auto-antibody titer can be used as a guide to prednisone therapy. However, in patients with a mild or moderate form, no such correlation is established.
Oxatomide in the Treatment of Pruritus senilis
Authors: Dupont C. , de Maubeuge J. , Kotlar W. , Lays Y. , Masson M.
Published: October 2009

The antiallergic drug oxatomide was evaluated in a double-blind placebo-controlled study in 35 patients with pruritus senilis. The trial was run in the wintertime, and the patients were orally given either 30 mg oxatomide b.i.d. (n = 19) or a placebo (n = 16) for 2 months. Complete suppression or marked improvement of the complaints was experienced by 79% of the patients given oxatomide and by 31% of the control patients. Oxatomide was superior to the placebo in reducing both the duration and the severity of itching. The need of additional topical medication was higher in the placebo group. Somnolence and cramps were each reported by 1 oxatomide-treated patient.
A Variant of Encephalomeningocele: Heterotopic Brain Tissue on the Scalp
Authors: Tanii Tsukasa , Hamada Toshio
Published: October 2009

A 2-year-old girl having a bald nodule on the scalp is reported. The tumor was circular, hemispherically elevated and had a dull reddish color. Roentgenologic studies revealed a defect of the underlying skull bone, and spina bifída occulta on the first and second sacral vertebra were found. Craniotomy was carried out. The tumor extended into the falx cerebri and reached to the tentorium cerebelli, and was not connected with the cerebrum. Histological examination showed insular brain tissue containing glial cells in the lower dermis. Around this tissue, there seemed to be vascular leptomeninges with numerous melanocytes and thickened fibrous elements, probably dura. From these findings, this case was diagnosed as a variant of encephalomeningocele, and as melanocytes physiologically exist on the leptomeninges, melanocytes in an encephalomeningocele may diagnostically identify the leptomeninges.
Linear Localized Coumarin Necrosis
Authors: Schwartz Robert Allen , Moore III Christopher , Lambert Clark
Published: October 2009

We report a 55-year-old man with coumarin necrosis. This drug eruption is sometimes a devastating gangrenous process in sites with abundant underlying adipose tissue. In our patient, however, it assumed an evanescent limited linear distribution on the skin, prompting this report.
Drug-Induced Oral Erythema Multiforme
Authors: Gebel K. , Hornstein O.P.
Published: October 2009

As reliable data on prevalence rates of drug-induced oral mucosa side effects are scarce in the medical literature, a retrospective analysis of drugs as possible inducers in 173 in-patients with either minor or major type of erythema multiforme (EM) admitted to the Erlangen University Department of Dermatology from 1970 through 1981 was carried out. In 62 of these cases precipitation by drugs was suspected by history, in 31 of them with oral mucosa involvement. In 11 out of 19 patients with mucocutaneous EM drug testing either in vivo or in vitro provided evidence for drug induction of EM.
A Case of Mixed Chancre
Authors: Folk Edvard S. , Vorland Lars H. , Bjorvatn Bjarne
Published: October 2009

A 39-year-old Norwegian seaman developed penile ulcerations after sexual contact overseas. The diagnosis of syphilitic chancre and of chancroid was confirmed. The ulcers healed after combined treatment with benzathine penicillin and trimethoprim-sulfamethoxazol.
Influence of 13-cis Retinoic Acid and of Arotinoid on the Cytochrome P-450 System in Rat Liver
Authors: Goerz G. , Hamm L. , Bolsen K. , Merk H.
Published: October 2009

Female Wistar rats were treated with either 13-cis retinoic acid or arotinoidethyl ester in a dose comparable to those used in humans over different periods up to 28 days. In the liver of the animals the following parameters were estimated: microsomal protein content, cytochrome P-450 content, and cytochrome P-450-dependent activities of enzymes such as aminopyrine-N-demethylase, arylhydrocarbon hydroxylase, and 7-ethoxycoumarin deethylase. Only a transitory increase of the aminopyrine-N-demethylase after 3 days of treatment could be demonstrated. From this animal study, there is no evidence of interactions between retinoids and drug-metabolizing monooxygenases, e.g., the metabolism of contraceptive active steroids.
Xanthomes, neurofibromatose et leucémie chez l’enfant
Authors: Song M. , Gheeraert P. , Jonckheer T. , Otten J. , Achten G.
Published: October 2009

A 14-month-old boy with neurofibromatosis and skin xanthomas associated with normal lipemia is described. Acute lymphocytic leukemia complication and its connection with the cutaneous disease are discussed.
Synergistic Bacterial Gangrene Caused by a Group A β-Haemolytic Streptococcus and a Staphylococus aureus
Authors: Colebunders R. , Matthys R. , Neutjens F. , Verselder R.
Published: October 2009

A patient who developed a synergistic bacterial gangrene caused by a group A β-haemolytic streptococcus and a Staphylococcus aureus is described.
Multiple Glomus Tumors Associated with Multiple Neoplasias
Authors: Chevrant-Breton J. , Dunn J.E. , Laudren A.
Published: October 2009

We report the case of a 60-year-old man who presented with a lentigo maligna melanoma, which led to the discovery of a malignant endobronchial tumor and who had noticed the appearance of disseminated multiple glomus tumors about 10 years before. The late onset of this form of benign vascular tumor raises the question whether multiple glomus tumors may have been, in this case, a cutaneous marker of the development of underlying malignancy.
Psoriasis and Hereditary Palmoplantar Keratoderma Complicated with a Dermatophyte Infection
Authors: Gamborg Nielsen Povl
Published: October 2009

In a 29-year-old woman suffering from hereditary palmoplantar keratoderma of the Unna Thost variety, psoriasis appeared at an age of 28 years. The keratoderma on the soles was complicated with a dermatophyte infection, which made the differential diagnosis towards psoriasis difficult. Histopathologic examination of punch biopsy from the soles showed no conclusive signs of psoriasis. An increased thickness of the horny layer, which in PAS staining showed fungus hyphae, was found.
A Combined Treatment in Prevention of Postgonococcal Urethritis
Authors: Patrone P. , Negosanti M. , Ghetti P. , Amato S. , Cevenini R. , Donati M. , Tosti A.
Published: October 2009

The authors report a study carried out on 82 patients affected with gonococcal urethritis, in order to investigate the activity of minocyclin in the prevention of postgonococcal urethritis.
Recherche chez l’homme du pouvoir phototoxique du peroxyde de henzoyle à 5%
Authors: Jeanmougin M. , Pedreiro J. , Bouchet J. , Civatte J.
Published: October 2009

In order to conform to the conditions in which a 5% benzoyl peroxide compound is being used, a new methodology has been developed and applied to 24 volunteers: photobiologic tests were performed and UVB irradiation at infra- and supra-MED times of exposure as well as UVA irradiation on usually covered and usually uncovered areas, after single and multiple applications. This double-blind study (vehicle alone and active substance alone) has been carried out in each subject. UVB phototoxicity resulted in the occurrence of an erythema for an infra-MED time of exposure and/or in changes in the erythema as compared to an adjacent control area for the supra-MED time of exposure. This was found in 8 patients (33%), only on repeatedly irradiated areas, but never with the vehicle alone. No UVA phototoxicity was evidenced. This study confirms the possible phototoxic action of benzoyl peroxide after UVB exposure. It emphasizes the usefulness of repeating the applications on both covered and uncovered areas in photosensitivity tests of a substance.
Generalized Vitiligo after Erythroderma
Authors: Schwartz Robert Allen , Trotter Marvin G.
Published: October 2009

We report a 65-year-old black man whose onset of an erythroderma was followed in 6 weeks by a generalized vitiligo. The etiology of the erythroderma was unclear, although a prostate adenocarcinoma was found on evaluation. This is to our knowledge the first patient reported with a vitiligo following exfoliative dermatitis, and the first report of two uncommon markers of internal malignancy (erythroderma and vitiligo) occurring with prostate adenocarcinoma in the same patient. We present a remarkable patient who developed a generalized vitiligo after presenting with an exfoliative dermatitis. This vitiligo produced depigmentation of almost all of the patient’s skin. A workup revealed a prostate carcinoma.
Methylprednisolone Pulse Therapy in Dermatomyositis
Authors: Yanagisawa T. , Sueishi M. , Nawata Y. , Akimoto T. , Nozaki T. , Koike T. , Tomioka H. , Kumagai A.
Published: October 2009

A high dose of methylprednisolone (pulse therapy) was given to 3 patients with uncontrolled dermatomyositis (DM) accompanied by severe muscle weakness. The effects of pulse therapy were compared with findings in 5 patients with severe DM who were treated with the usual dose of prednisolone (controls). The pulse therapy led to an improvement in the clinical symptoms in the 3 patients with uncontrolled DM, who were in danger of aspiration pneumonia. A rapid reduction in muscle enzyme levels in this group was also evident.
The Follicular Biopsy
Authors: Mills, Jr. Otto H. , Kligman Albert M.
Published: October 2009

The ‘follicular biopsy’ is an extension of the noninvasive ‘surface biopsy’ technique originated by Dawber and Marks. A quick-setting cyanoacrylate polymer is used to extract the contents of sebaceous follicles. The retrieved material can be examined histologically at the light or electron microscopic level. Many types of analyses may be performed; microbial density, lipid components (acne), mite population (Demodex), hair retention (trichostasis), penetration of topical drugs and chemicals, localization of enzymes, etc. The follicular biopsy is useful for studying the contents of sebaceous follicles in health and disease.
Treatment of Keloids with Excision and Postoperative X-Ray Irradiation
Authors: Enhamre Anders , Hammar Hans
Published: October 2009

During a 9-year period 47 patients with 62 keloids, treated with excision and postoperative superficial X-ray irradiation, were included in a retrospective study. The follow-up time was 6 months to 9 years. 88% experienced a good or excellent result. Single or fractioned dose and time interval between excision and radiation did not influence the result. Hyperpigmentation was noted as a side effect in 16 of 47 patients. More favorable results were obtained in the treatment of small keloids and of keloids located in the head-neck area compared to those on the trunk and the extremities.
Unusual Acquired Hyperkeratosis: A Case Report
Authors: Fanti P.A. , Patrizi A. , Varotti C.
Published: October 2009

The authors describe an acquired hyperkeratosis occurring in a 74-year-old male. To the authors’ knowledge this disease shows a pathological picture never before described in the literature, consisting of the presence of a large number of acrosyringum-like structures not connected with the dermal sweat ducts in hyperkeratotic skin.
Erythropoietic Protoporphyria Showing Solar Purpura
Authors: Torinuki Wakio , Miura Takashi
Published: October 2009

An 11-year-old girl with erythropoietic protoporphyria is described. She was admitted to our hospital complaining of swelling and purpura on her arms resulting from overexposure to solar radiation. An elevated level of protoporphyrin in the red blood cells and feces was detected by thin-layer chromatography and fluorescent scanning analysis.
Discoid Lupus erythematosus and Carrier Status of X-Linked Chronic Granulomatous Disease
Authors: Lindskov Rune , Munkvad Jan Mikael , Valerius Niels Henrik
Published: October 2009

Discoid lupus erythematosus (DLE)-like lesions and recurrent aphthous-like stomatitis have often been described in carriers of X-linked chronic granulomatous disease (CGD). The capacity of the polymorphonuclear leucocytes to reduce nitroblue tetrazolium (NBT) after stimulation with phorbol myristate acetate (NBT test), a function of normal oxidative metabolism, was determined in 34 patients with DLE of whom 17 also suffered from recurrent stomatitis. The NBT test turned out to be normal in all 34 patients, indicating that none of them were carriers of X-linked CGD. In spite of the negative results of this study it is recommended that all female patients suffering from DLE in combination with recurrent aphthous-like stomatitis are screened by means of the NBT test, because this examination is simple and inexpensive, and because of the importance of identifying carriers of CGD with a view to genetic guidance.
Suppression of Palmoplantar Pustulosis Symptoms with Oral 8-Methoxypsoralen and High-Intensity UVA Irradiation
Authors: Paul Riitta , Jansén Christer T.
Published: October 2009

9 patients with long-standing palmoplantar pustulosis were treated with oral 8-methoxypsoralen and high-intensity UVA irradiation (PUVA, 46.2 mW/cm2), 20 irradiations with single doses of up to 14.8 J/cm2 resulted in good or excellent clearing in 4 out of 5 patients, while none of 4 patients receiving 5–6 irradiations of up to 5.2 J/cm2 improved significantly. Comparison with earlier investigations leads to the conclusion that systemic PUVA is more efficient than topical PUVA in the treatment of palmoplantar pustulosis. This may result from different skin distribution of psoralen or from a more rapid decline in the photosensitivity of topically medicated skin during prolonged irradiation as compared to skin sensitized by oral psoralen administration. The use of a high-irradiance UVA source diminishes the influence of this time factor and improves patient compliance.
A Case of Localized Darier’s Disease
Authors: Ueda K. , Maruo M. , Matsubara M. , Kusaba K.
Published: October 2009

A case of localized Darter’s disease was reported. The patient was a 36-year-old Japanese woman, and hyperkeratotic papules in zosteriforme arrangement were persistently noted on the left forehead since the age of 20 years. Histological appearance was same as in classical Darter’s disease. Skin atrophy due to long-term application of corticosteroid ointment was observed. Aromatic retinoid ointment was effective in the treatment of the lesions. The literature on localized Darter’s disease is reviewed.
Short-Duration Dithranol Therapy for Psoriasis
Authors: Hindryckx P. , De Bersaques J.
Published: October 2009

40 outpatients with psoriasis vulgaris of limited extent were treated with daily brief applications of a 1,2 or 3% dithranol ointment. The treatment was effective in cases of large plaques, small lesions and guttate psoriasis. There was a very poor therapeutic response in palmoplantar psoriasis and in residual lesions after Ingram’s regimen.
Fasciitis eosinophilica
Authors: Bowszyc J. , Stępień B. , Janicka D.
Published: October 2009

Hypergamma-globulinemia and eosinophilia in the peripheral blood were found in a 4-year-old girl with scleroderma-like lesions within the upper and lower limbs. Histological examination excluded scleroderma. After 6 weeks of treatment with steroids, almost a complete retreat of scleroderma-like lesions was achieved.
A Rare Tumor: Subungual Chondroma
Authors: Ayala F. , Lembo G. , Montesano M.
Published: October 2009

A rare case of subungual chondroma is reported; the differential diagnosis of the tumor is briefly discussed.
Parasagittal Transinsular Electrodes for Stereo-EEG in Temporal and Insular Lobe Epilepsies
Authors: Gil Robles Santiago , Gelisse Philippe , El Fertit Hassan , Tancu Cornel , Duffau Hugues , Crespel Arielle , Coubes Philippe
Published: October 2009

Objective: Direct invasive EEG recordings of the insula – due to its particular anatomical position, deeply seated between both opercula – can only be performed with intracerebral electrodes. To date, the technique most commonly used for insular stereoelectroencephalography (SEEG) is the orthogonal-transopercular electrode approach with the Talairach methodology. We propose another technique utilizing MRI with transinsular parasagittal electrodes and a posterior entry point. This avoids passing through the opercula and sylvian vessels running over the insular surface. Methods: Nine patients, whose seizures implicated the insula, underwent brain surgery. Under general anesthesia with a Leksell frame, 3D-T1 SPGR MRI with gadolinium enhancement was achieved. Surgical planning was performed using the StealthStation with an entry point in the parieto-occipital junction setting the target for the first contact of the lead at the most anterior part of the insula. The trajectory was manipulated in order to have at least 4 contacts per electrode track within the insular cortex. All patients had a postoperative MRI to verify the exact position of each contact. Results: Insular seizures were recorded in all patients. There was neither intracranial bleeding nor infection. In all of the cases, except 1, the seizures recorded were found to be propagations of the primary epileptic zone located in the temporal lobe, either in the mesial structures or the superior temporal gyrus. Eight patients were operated, 7 with an antero-mesial temporal lobectomy and 1 with dysplasia of the superior temporal gyrus. No insular resections were performed. Conclusion: We report a novel technique for insular SEEG with parasagittal electrodes, parallel to the insular cortex, with an entry point at the parieto-occipital junction. This technique is based entirely on use of MRI, and avoids passing through the opercula and sylvian vessels.
Chronic Deep Brain Stimulation for Segmental Dystonia
Authors: Woehrle Johannes C. , Blahak Christian , Kekelia Kety , Capelle Hans-Holger , Baezner Hansjoerg , Grips Eva , Weigel Ralf , Krauss Joachim K.
Published: October 2009

Fourteen consecutive patients with segmental dystonia underwent chronic deep brain stimulation (DBS) surgery in the frame of a prospective study protocol. Twelve patients received chronic pallidal stimulation, while 2 patients with prominent dystonic tremor received chronic thalamic ventrointermediate nucleus stimulation. Twelve patients had primary dystonia, and 2 patients secondary dystonia. The Burke-Fahn-Marsden dystonia rating scale (BFM motor) showed a mean relative improvement of 57.3% at the first follow-up (FU1, mean 7 months) and 57.8% at the second follow-up (FU2, mean 16 months). The mean BFM scores were 34.9 ± 17.7 preoperatively, 14.9 ± 11.7 at FU1, and 14.8 ± 10.3 at FU2. Scores of the disability subscale improved by 43% at FU1 and 36% at FU2. Improvement was comparatively less in those patients with secondary dystonia. Dysarthria was a limitation of DBS in 4 patients when using high voltage. Overall, chronic DBS is a very effective treatment option for medically refractory segmental dystonia.
Possible Dosage Regimens for Topical Steroids, Assessed by Vasoconstrictor Assays Using Multiple Applications
Authors: Woodford R. , Haigh J.M. , Barry B.W.
Published: October 2009

The bioavailabilities and activities of three amcinonide preparations and Betnovate cream were assessed using three multiple-dosage regimen vasoconstrictor assays in 10 volunteers. Applications were made once daily, twice daily and every alternate day with an initial three times daily loading dose applied on the first day only. Blanching responses first increased and then decreased due to tachyphylaxis. It is proposed that clinically the most advantageous dosage regimen is a once daily application with no loading dose.
PUVA Therapy Does Not Modify Arsenic Carcinogenesis in Psoriatics
Authors: Angele Ruth , Schneider Bernhard , Jung Ernst G.
Published: October 2009

Follow-up examinations of 84 psoriatics after 4 or 5 years of PUVA therapy revealed that keratoses or skin tumours developed in 8 cases. 6 of these patients showed typical arsenic keratoses and 5 of them had arsenic intake decades ago. PUVA therapy does not modify the clinical behaviour of arsenic carcinogenesis.
Cutis verticis gyrata with Metabolic Abnormalities
Authors: Leibowitz Michael R. , Kalk John
Published: October 2009

An adult Black South African man with forme fruste pachydermoperiostosis is described. The patient had cutis verticis gyrata, hyperhidrosis, sebaceous plugging and an acneform rash. Basal and dynamic endocrine studies revealed that the hypothalamic, pituitary, thyroid, adrenal, gonadal axes and growth hormone secretion were all normal, but urinary excretion of 17-hydroxy- and corticosteroids, and the prolactin response to thyrotropin-releasing hormone were depressed. Urinary levels of asparagine were markedly elevated and serum levels were subnormal indicating a possible renal leak of this amino acid; glutamic acid and ornithine were present in smaller quantities in the urine. All other tests of proximal and distal renal tubular function were normal. There is no evidence from our studies to suggest a hormonal basis for pachydermoperiostosis. The amino aciduria may be a chance association of, or an (additional) occasional manifestation of the syndrome.
Immune Complexes in Pemphigus and Bullous Pemphigoid
Authors: Ahmed Razzaque , Moy Ronald L. , Chia David , Barnett Eugene V.
Published: October 2009

28 serum and 10 blister fluid specimens obtained from 28 pemphigus vulgaris (PV) patients were assayed for immune complexes using the polyethylene glycol (PEG) assay. 11% of sera and 30% of the blister fluids had elevated levels of immune complexes. Anti-intercellular cement substance (ICS) antibody could not be detected in PEG precipitates, but was present in the supernatants from the serum. However, anti-ICS antibody was found in 70% of the precipitated complexes from the blister fluid.
Isolation of an Elastase-Like Enzyme from Skin Lesions with Sweet’s Syndrome
Authors: Hamanaka Kazuko , Ishizu Kenji , Takasugi Sumiyoshi , Toki Naotika
Published: October 2009

In the present study, an elastase-like enzyme which possessed elastolytic, proteolytic and Nα-Acetyl-L-tyrosine ethyl ester hydrolytic activities was extracted from skin lesions with Sweet’s syndrome.
Photosensibilisation au carprofène (Imadyl®), un nouvel anti-inflammatoire non stéroïdien
Authors: Merot Yves , Harms Monika , Saurat Jean-Hilaire
Published: October 2009

Carprofen is a new non-steroidal anti-inflammatory drug and a phenylpropionic acid derivative. It seldom causes pruritus, erythema or urticaria. Since 1 year, we have observed 8 photosensitive eruptions associated with Carprofen, a surprising side effect for this group of derivatives. The skin eruption started from 4 days to 3 weeks after the initiation of the treatment and was always limited to the exposed areas of the skin. The eruption was erythematopapular, but also vesiculous or bullous. 2 cases required systemic corticosteroids. Photo patch tests were positive, suggesting a photoallergic process. Phototherapy should be avoided in patients treated with carprofen.
Reactive Perforating Collagenosis
Authors: Rotta Osmar
Published: October 2009

3 cases of reactive perforating collagenosis in siblings are reported which were characterized clinically by typical umbilicated papules at sites exposed to traumatism. The histopathological feature is characterized by a cup-shaped depression of the epidermis together with extrusion of collagen fibers at its base.
Aromatisches Retinoid – orale Photochemotherapie (RePUVA) bei aktinischem Retikuloid
Authors: Hunziker T. , Zala L. , Krebs A.
Published: October 2009

RePUVA treatment proved to be more efficient than simple oral photochemotherapy in a patient suffering from actinic reticuloid. This combined therapy may solve some problems of long-term treatment in actinic reticuloid.
New Histochemical and Ultrastructural Findings in Three Cases of ‘Papillomatose Papuleuse Confluente et Réticulée (Gougerot-Carteaud)’
Authors: Groh Veronica , Sigg Christian , Schnyder Urs.W.
Published: October 2009

After we could demonstrate amyloid deposits both histochemically and ultrastructurally in the papillary body of typical skin lesions in 1 patient with ‘papillomatose papuleuse confluente et réticulée’ Gougerot-Carteaud (PCR), 2 other patients of our clinic already known to suffer from PCR were reinvestigated. Here, too, a similar amyloid storage was noted. In this paper, possible hypotheses concerning the etiopathology of these new results are proposed and the nosological significance of our findings is discussed, i.e. the PCR might lose its identification as a distinct pathological entity by the fact that 3 cases with the clinical picture of PCR can be subsumed under the nosological entity of primary localized skin amyloidoses.
Phagocytosis of Erythrocytes by Keratinocytes in Human and Animal Epidermis
Authors: Boiron G. , Surleve-Bazeillé J.E. , Tamisier J.M. , Guillet G. , Maleville J.
Published: October 2009

The phenomenon reported here was observed in 2 cases of purpura pigmentosa progressiva and in a case of experimental pityriasis of the guinea pig. Erythrocytes were seen within the epidermis by light microscopy, and these were seen within the keratinocytes by electron microscopy. These observations establish the phagocytosis of erythrocytes by keratinocytes in reaction to a dermal inflammation and/or an epidermal hyperplasia. It is of a special interest for the understanding of the dermoepidermal interrelationship.
Appearance of Lupus erythematosus in a Patient with Lichen planus Treated by Isoniazide
Authors: Grunwald Marcelo , David Michael , Feuerman Eleasar J.
Published: October 2009

We hereby present a case report of a patient suffering from lichen planus and who, while under treatment with isoniazide, developed skin lesions and serologic abnormality which were typical of lupus erythematosus. Laboratory data and course of the disease indicate that drugs play a role in the pathogenesis of the disease. The nature of relationship between lichen planus and lupus erythematosus is discussed.
Dermal Vasculitis due to Coumadin Hypersensitivity
Authors: Tanay Amir , Yust Israel , Brenner Sarah , Koffler Michael , Abramov Arie L.
Published: October 2009

A 65-year-old patient developed nonpruritic purpuric skin eruptions following 10 days of coumadin treatment. Skin biopsy revealed vasculitis and immunofluorescent studies demonstrated the presence of IgM and C3 deposits in the walls of the affected blood vessels. Rechallenge with coumadin was followed by reappearance of the skin eruptions. Indirect mast cell degranulation test and migration inhibiting factor test were positive in the presence of coumadin. These findings strongly suggest that the skin lesions were induced by an immunologic reaction to warfarin.