bluuebunny/crossref_metadata_2025 huggingface dataset:
Dual Antiplatelet Therapy in Minor Stroke/Transient Ischemic Attack – An Updated Network Meta-Analysis
Authors: Lun Ronda , Zitikyte Gabriele , Roy Danielle Carole , Dhaliwal Shan , Dowlatshahi Dar
Published: September 2023

We previously analyzed five trials on ticagrelor/aspirin versus clopidogrel/aspirin in patients with minor stroke/ TIA in a network meta-analysis. We updated our search and identified 311 new citations with one study for inclusion: CHANCE2 enrolled patients with CYP2C19 loss-of-function alleles and randomized them to ticagrelor/aspirin or clopidogrel/aspirin. Pooling of CHANCE2 with the original studies could not be completed due to violation of NMA assumptions, due to significant inconsistency. This suggests patients with CYP2C19 loss-of-function alleles represent a subpopulation that is inherently different from the general stroke population in their antiplatelet response. Results from CHANCE-2 may not be generalizable without genotype testing.
The Standardization of the Emergency Department Response to Chemical, Biological, Radiological, and Nuclear (CBRN) Events: Human Factors/Ergonomics Approach
Authors: Razak Saydia , Hignett Sue , Barnes Jo , Hancox Graham
Published: September 2023

Objective:

To provide standardized recommendations for the emergency department (ED) response to chemical, biological, radiological, and nuclear (CBRN) events by combining the human factors/ergonomics method of hierarchical task analysis with the theoretical framework for Work as Imagined versus Work as Done.

Methods:

Document analyses were used to represent CBRN response operational procedures. Semi-structured interviews using scenario cards were carried out with 57 first receivers (ED staff) to represent CBRN practice at 2 acute hospitals in England.

Results:

Variability existed in general organizational responsibilities associated with the CBRN response. Variability was further evident in top level CBRN tasks and CBRN phases at both EDs. Operational procedures focused on tasks such as documentation, checking, and timing. CBRN practice focused on patient needs through assessment, treatment, and diagnosis.

Conclusion:

The findings provide top-down and bottom-up insights to enhance the ED CBRN response through standardization. The standardized CBRN action card template embeds the choice approach to standardization. The standardized CBRN framework implements the streamlined categorization of CBRN phases. Work as Imagined versus Work as Done is a useful theoretical framework to unpack a complex sociotechnical system, and hierarchical task analysis is an effective system mapping tool in health care.
A theory of change for community-initiated mental health care in the United States
Authors: Breuer Erica , Morris Angelika , Blanke Laura , Pearsall Miriam , Rodriguez Roxana , Miller Benjamin F. , Naslund John A. , Saxena Shekhar , Balsari Satchit , Patel Vikram
Published: September 2023

Mental health service delivery needs radical reimagination in the United States where unmet needs for care remain large and most metrics on the burden of mental health problems have worsened, despite significant numbers of mental health professionals, spending on service provision and research. The COVID-19 pandemic has exacerbated the need for mental health care. One path to a radical reimagination is “Community Initiated Care (CIC)” which equips and empowers communities to address by providing brief psychosocial interventions by people in community settings. We co-developed a theory of change (ToC) for CIC with 24 stakeholders including representatives from community-based, advocacy, philanthropic and faith-based organizations to understand how CIC could be developed and adapted for specific contexts. We present a ToC which describes ways in which the CIC initiative can promote and strengthen mental health in communities in the United States with respect to community organization and leadership; community care and inclusion and normalizing mental health. We propose 10 strategies as part of CIC and propose a way forward for implementation and evaluation. This CIC model is a local, tailored approach which can expand the role of community members to strengthen our response to mental health needs in the United States.
Dairy intake and risk of hip fracture in prospective cohort studies: non-linear algorithmic dose-response analysis in 486 950 adults
Authors: Mishra Suruchi , Baruah Kavitha , Malik Vasanti S. , Ding Eric L.
Published: September 2023

Previous studies on the relationship between dairy consumption and hip fracture risk have reported inconsistent findings. Therefore, we aimed to conduct an algorithmically driven non-linear dose-response meta-analysis of studies assessing dairy intake and risk of developing incident hip fracture. Meta-analysis from PubMed and Google Scholar searches for articles of prospective studies of dairy intake and risk of hip fracture, supplemented by additional detailed data provided by authors. Meta-regression derived dose-response relative risks, with comprehensive algorithm-driven dose assessment across the entire dairy consumption spectrum for non-linear associations. Review of studies published in English from 1946 through December 2021. A search yielded 13 studies, with 486 950 adults and 15 320 fractures. Non-linear dose models were found to be empirically superior to a linear explanation for the effects of milk. Milk consumption was associated with incrementally higher risk of hip fractures up to an intake of 400 g/d, with a 7 % higher risk of hip fracture per 200 g/d of milk (RR 1⋅07, 95 % CI 1⋅05, 1⋅10; P < 0⋅0001), peaking with 15 % higher risk (RR 1⋅15, 95 % CI 1⋅09, 1⋅21, P < 0⋅0001) at 400 g/d versus 0 g/d. Although there is a dose-risk attenuation above 400 g/d, milk consumption nevertheless continued to exhibit elevated risk of hip fracture, compared to zero intake, up to 750 g/d. Meanwhile, the analysis of five cohort studies of yoghurt intake per 250 g/d found a linear inverse association with fracture risk (RR 0⋅85, 95 % CI 0⋅82, 0⋅89), as did the five studies of cheese intake per 43 g/d (~1 serving/day) (RR 0⋅81, 95 % CI 0⋅72, 0⋅92); these studies did not control for socioeconomic status. However, no apparent association between total dairy intake and hip fracture (RR per 250 g/d of total dairy = 0⋅97, 95 % CI 0⋅93, 1⋅004; P = 0⋅079). There were both non-linear effects and overall elevated risk of hip fracture associated with greater milk intake, while lower risks of hip fracture were reported for higher yoghurt and cheese intakes.
SimSpin v2.6.0—constructing synthetic spectral IFU cubes for comparison with observational surveys
Authors: Harborne K. E. , Serene A. , Davies E. J. A. , Derkenne C. , Vaughan S. , Burdon A. I. , Lagos C. del P , McDermid R. , O’Toole S. , Power C. , Robotham A. S. G. , Santucci G. , Tobar R.
Published: September 2023

In this work, we present a methodology and a corresponding code-base for constructing mock integral field spectrograph (IFS) observations of simulated galaxies in a consistent and reproducible way. Such methods are necessary to improve the collaboration and comparison of observation and theory results, and accelerate our understanding of how the kinematics of galaxies evolve over time. This code, SimSpin, is an open-source package written in R, but also with an API interface such that the code can be interacted with in any coding language. Documentation and individual examples can be found at the open-source website connected to the online repository. SimSpin is already being utilised by international IFS collaborations, including SAMI and MAGPI, for generating comparable data sets from a diverse suite of cosmological hydrodynamical simulations.
Stabilization of the Kawahara–Kadomtsev–Petviashvili equation with time-delayed feedback
Authors: Capistrano–Filho Roberto de A. , Gonzalez Martinez Victor Hugo , Muñoz Juan Ricardo
Published: September 2023

Results of stabilization for the higher order of the Kadomtsev-Petviashvili equation are presented in this manuscript. Precisely, we prove with two different approaches that under the presence of a damping mechanism and an internal delay term (anti-damping) the solutions of the Kawahara–Kadomtsev–Petviashvili equation are locally and globally exponentially stable. The main novelty of this work is that we present the optimal constant, as well as the minimal time, that ensures that the energy associated with this system goes to zero exponentially.
Asymptotic formulas of the eigenvalues for the linearization of the scalar field equation
Authors: Miyamoto Yasuhito , Takemura Haruki , Wakasa Tohru
Published: September 2023

We establish asymptotic formulas for all the eigenvalues of the linearization problem of the Neumann problem for the scalar field equation in a finite interval

\[ \begin{cases} \varepsilon^2u_{xx}-u+u^3=0, & 0< x<1,\\ u_x(0)=u_x(1)=0. \end{cases} \]

In the previous paper of the third author [T. Wakasa and S. Yotsutani, J. Differ. Equ. 258 (2015), 3960–4006] asymptotic formulas for the Allen–Cahn case

$\varepsilon ^2u_{xx}+u-u^3=0$

were established. In this paper, we apply the method developed in the previous paper to our case. We show that all the eigenvalues can be classified into three categories, i.e., near

$-3$

eigenvalues, near

$0$

eigenvalues and the other eigenvalues. We see that the number of the near

$-3$

eigenvalues (resp. the near

$0$

eigenvalues) is equal to the number of the interior and boundary peaks (resp. the interior peaks) of a solution for the nonlinear problem. The main technical tools are various asymptotic formulas for complete elliptic integrals.
THREE SETS OF SHACKLES AT OLD SARUM, THE ‘ARREST OF THE BISHOPS’ IN 1139 AND THE POWER OF SHAMING IN THE ANGLO-NORMAN WORLD
Authors: Langlands Alex
Published: September 2023

In 1913 a set of leg shackles was recovered among skeletal remains during excavations at the east end of the ruinous cathedral of Old Sarum, Wiltshire. A recent examination of the excavation’s photographic record indicates that two further similar examples were recovered at the same time. Since the early twentieth century a body of scholarship has refined our understanding of the arrangement of the east end of the cathedral, and a closer examination of the archive in the light of this work allows for both skeletal remains and shackles to be confidently located in an archaeological context related to the tomb of Bishop Roger. This paper explores the value this evidence has for our understanding of the so-called ‘Arrest of the Bishops’, an event of notable constitutional significance in the tumultuous reign of King Stephen. It goes on to examine the shock with which the event was recalled by contemporary writers to reflect on the power of shaming and incarceration as a device of extortion, political manipulation and the infliction of social death. The integral nature of iron bonds in these strategies lends them a socio-symbolic role and the reception of their use in this well-recorded episode may facilitate the interpretation of such items from early and high medieval contexts when, frequently, primary provenance is lacking.
On the reproductive strategies post-colony foundation: major termite pest species with distinct ecological habits differ in their oviposition dynamics
Authors: da Silva Iago Bueno , Costa-Leonardo Ana Maria
Published: September 2023

Termite colony foundation precedes the incipient stage, when the first oviposition cycle takes place, followed by months of reproductive inactivity. The royal couple is supposed to cease oviposition during this period, investing energy to care for the first brood. When a suitable number of alloparents differentiate, egg-laying resumes. Here we followed oviposition dynamics, embryo development and queen/king body changes in laboratory colonies of the major pest species Coptotermes gestroi (Rhinotermitidae) and Cryptotermes brevis (Kalotermitidae) during 9 months. We show that they differ in these oviposition dynamics, as C. gestroi queens displayed an uninterrupted oviposition whereas C. brevis laid a cohort of eggs and ceased oviposition during a 3-month period (lag phase). C. gestroi oviposition dynamic was remarkable and suggests that occurrence of progeny was not a limiting factor, thus queens and kings were able to concomitantly invest energy in reproduction and parental care. These findings contrast those reported for rhinotermitids from temperate areas, and we discuss the likely reasons for such a condition, including endogenous rhythms, avoidance of a high mortality rate of the first progeny and adaptation to the weather conditions of the Neotropical region. Oviposition dynamic in C. brevis resembled those of several termite species, in which the royal couple cease reproduction to care for the first brood. Rearing conditions did not influence oviposition dynamics (egg-laying cycle followed by a lag phase), thus our results on the oviposition of C. gestroi and C. brevis correspond to different reproductive strategies post-foundation adopted by these pest species.
Bridging the Gap: Reparations in Refugee Camps
Authors: Serafeimidi Dimitra , Vilchez Marcos Lorena , Puri Shivani
Published: September 2023

The commission of large-scale international crimes (namely, crimes against humanity, war crimes, and genocide) could result in populations fleeing from their homes, seeking protection. There is an increasing number of victims of these crimes who have been forcibly displaced and currently live in settlements widely known as refugee camps. Victims of international crimes have the right to receive reparations for the harm they have suffered. This means that international criminal tribunals, particularly the International Criminal Court, will have to consider reparations for victims in refugee camps in the near future when the victims seek to enforce their right to reparations. To date, the delivery of reparations in these contexts has not been analysed adequately in the academic literature; this is the gap that this article aims to discuss. The article explores the extent to which it is suitable and feasible to deliver reparations in refugee camps. One of the main arguments is that living in a refugee camp could compound the crime-related harm already sustained by victims. This feature, along with the instability of the situation of victims and the infrastructure of the camp, constitute key characteristics of refugee camps and should each be taken into consideration in delivering reparations. As this article suggests, the instability of the victims’ situation will inform which modalities of reparations are suitable to be delivered in the context of a refugee camp. Subsequently, the compounded harm and the camp's infrastructure will inform which particular reparative measures, corresponding to each modality, will be suitable and feasible – respectively – to be delivered. The methodology includes desk-based and qualitative research and analysis of primary and secondary sources and case studies.
Insights from the media into the bird trade in India: an analysis of reported seizures
Authors: Kalra Sharda , Davies Alisa , Martin Rowan O. , Poonia Asha
Published: September 2023

India has an extensive bird trade that provides income and livelihoods for many people but involves considerable unregulated and illegal activity, threatening both native and exotic species and posing potential health risks to people and wildlife. Action to curb illegal trade is vital, but there is currently a lack of information on trade routes and the species involved to inform the development of strategies to address such trade. We therefore examined media reports of bird trade seizures published during 2010–2020 as a cost-effective approach to gaining insights into the composition and structure of the bird trade in India. We collected 182 media reports referring to 109 seizure events by searching for keywords on popular search engines and Indian newspaper websites. We found that 25,850 birds were seized, most frequently members of the family Psittacidae. Of the 58 species identified, 18 were native and 40 non-native to India. The greatest numbers of birds were seized in Uttar Pradesh. Analyses of trade networks indicate that Uttar Pradesh is an important trade hotspot particularly for native species and has strong transnational connections with neighbouring Nepal. We identified West Bengal as an important trade hotspot, particularly for non-native species, probably because of its extensive land borders with neighbouring countries, including Bangladesh. Our study highlights priority areas for interventions as well as key knowledge gaps that need to be addressed to facilitate the development of strategies to manage illegal, unsustainable and otherwise harmful trading of birds.
HOW TO NAME A TRIREME
Authors: McArthur Mills
Published: September 2023

The names of Athenian warships are a valuable source for cultural history, but scholars have long laboured without a sense of how these names were chosen. In a recent article, the present author has suggested that naval architects (master craftsmen elected by the Athenian Assembly) were responsible for naming each vessel they built. This explanation applies to the great majority of Athenian warship names known to us, but exceptions to the rule remain. Naval architects cannot have named vessels they did not build, and we know of several foreign-built ships (e.g., captured or donated ships) in the Athenian fleet. Vessels with the special status of ‘sacred triremes’ must also have followed their own unique naming procedure. Such exceptional cases are the subject of this paper.
Human genomic data have different statistical properties than the data of randomised controlled trials
Authors: Borger Mirjam J. , Weissing Franz J. , Boon Eva
Published: September 2023

Madole & Harden argue that the Mendelian reshuffling of genes and genomes is analogous to randomised controlled trials. We are not convinced by their arguments. First, their recipe for meeting the demands on randomised experiments is inherently inconsistent. Second, disequilibrium across chromosomes conflicts with their assumption of statistical independence. Third, the genome-wide association study (GWAS) method has many pitfalls, including low repeatability.
Increasing the use of functional and multimodal genetic data in social science research
Authors: Nephew Benjamin C. , Murgatroyd Chris , Polcari Justin J. , Santos Hudson P. , Incollingo Rodriguez Angela C.
Published: September 2023

Genetic studies in the social sciences could be augmented through the additional consideration of functional (transcriptome, methylome, metabolome) and/or multimodal genetic data when attempting to understand the genetics of social phenomena. Understanding the biological pathways linking genetics and the environment will allow scientists to better evaluate the functional importance of polygenic scores.
Burt uses a fallacious motte-and-bailey argument to dispute the value of genetics for social science
Authors: Zietsch Brendan P. , Abdellaoui Abdel , Verweij Karin J. H.
Published: September 2023

Burt's argument relies on a motte-and-bailey fallacy. Burt aims to argue against the value of genetics for social science; instead she argues against certain interpretations of a specific kind of genetics tool, polygenic scores (PGSs). The limitations, previously identified by behavioural geneticists including ourselves, do not negate the value of PGSs, let alone genetics in general, for social science.
Polygenic risk scores cannot make their mark on psychiatry without considering epigenetics
Authors: Gooding Diane C. , Auger Anthony P.
Published: September 2023

We generally agree with Burt's thesis. However, we note that the author did not discuss epigenetics, the study of how the environment can alter gene structure and function. Given epigenetic mechanisms, the utility of polygenic risk scores (PRS) is limited in studies of development and mental illness. Finally, in this commentary we expand upon the risks of reliance upon PRSs.
Cognitive traits are more appropriate for genetic analysis than social outcomes
Authors: Ramus Franck
Published: September 2023

The critique of the genetics of complex social outcomes is partly well-founded, insofar as social outcomes sometimes have unreliable relations with cognitive traits. But the correct conclusion is not to dismiss the entire field altogether. Rather, the implication is to redirect geneticists' attention to the stable cognitive phenotypes that are natural candidates for genetic analysis.
Animal proverbs
Authors: Landmann Julia , Ganz Yannick
Published: September 2023

Proverbs exist in a plethora of languages to express worldly wisdom, frequently in a metaphorical way. A number of proverbs are documented in more than one language since speakers adopt them from cultures they have been in contact with. The focus of the present study is on animal proverbs in English which have a foreign equivalent in another language, such as French, Latin, Greek, Japanese or Arabic. The Oxford Dictionary of Proverbs (henceforth referred to as the ODP), edited by Jennifer Speake in 2015, is a valuable source for collecting the variety of animal proverbs which have become established in English over time.
ROBERT TRIFFIN, JAPAN, AND THE QUEST FOR ASIAN MONETARY UNION
Authors: Maes Ivo , Pasotti Ilaria
Published: September 2023

Especially with the Asian financial crisis of 1997–98, Asian countries have advocated a profound reform of the international financial architecture. Their proposals focused on two main axes: a reform of the global financial system, and stronger regional monetary integration in Asia. There are here significant parallels with the ideas of Robert Triffin (1911–1993). Triffin became famous with trenchant analyses of the vulnerabilities of the international monetary system. The Triffin dilemma is still present among international monetary policy-makers, also in Asia. Triffin put forward several proposals for reforming the global monetary system, but he also developed proposals for regional monetary integration. These were very much based on his experience with the European Payments Union, and focused on the creation of a (European) reserve fund and a (European) currency unit. In this paper we focus on Triffin’s proposals for an Asian payments union in the late 1960s, giving special attention to Japan (in Triffin’s time, the biggest Asian economy; moreover, Triffin had an important Japanese network).
Lessons from a multicenter, international, large sample size analysis of patients with obsessive–compulsive disorders: an overview of the ICOCS Snapshot studies
Authors: Vismara Matteo , Benatti Beatrice , Fineberg Naomi A. , Hollander Eric , Van Ameringen Michael , Menchon Jose M. , Zohar Joseph , Dell’Osso Bernardo
Published: September 2023

Obsessive–compulsive disorder (OCD) is a prevalent and highly disabling condition, characterized by a range of phenotypic expressions, potentially associated with geo-cultural differences. This article aims to provide an overview of the published studies by the International College of Obsessive-Compulsive Spectrum Disorders, in relation to the Snapshot database which has, over the past 10 years, gathered clinical naturalistic data from over 500 patients with OCD attending various research centers/clinics worldwide. This collaborative effort has provided a multi-cultural worldwide perspective of different socio-demographic and clinical features of patients with OCD. Data on age, gender, smoking habits, age at onset, duration of illness, comorbidity, suicidal behaviors, and pharmacological treatment strategies are presented here, showing peculiar differences across countries.
Emerging trends: Smooth-talking machines
Authors: Church Kenneth Ward , Yue Richard
Published: September 2023

Large language models (LLMs) have achieved amazing successes. They have done well on standardized tests in medicine and the law. That said, the bar has been raised so high that it could take decades to make good on expectations. To buy time for this long-term research program, the field needs to identify some good short-term applications for smooth-talking machines that are more fluent than trustworthy.
Understanding the interplay between jets and ISM for winged radio galaxies
Authors: Giri Gourab , Vaidya Bhargav
Published: September 2023

In this work, we investigate the formation and early evolution phase of X-shaped radio galaxies using the Back-flow model. We show how the X-like winged morphology evolves over time in a tri-axial ambient medium, naturally. At this early stage of formation, we demonstrated that both the pair of jet lobes are actively pushing the ambient material out of their path of propagation, forming (X-ray) cavities that are surrounded by a shocked shell (X-ray bright rims) of swept materials. We also noticed how turbulent the wing is in comparison to the active lobe, generating sites of random shocks, indicating that the wings are not passively evolving structures. This study demonstrated that the ambiguous morphology observed in jets is also imprinted over the ambient medium, providing an alternative perspective in understanding the underlying physical process causing such ambiguities. Finally, we indicate that shearing instabilities cause mixing of ambient material at the shearing interface.
Milliarcsecond Core Size Dependence of the Radio Variability of Blazars
Authors: Hsu Po-Chih , Yi Koay Jun , Matsushita Satoki , Hwang Chorng-Yuan , Hovatta Talvikki , Kiehlmann Sebastian , Max-Moerbeck Walter , Pearson Tim , Readhead Anthony , Reeves Rodrigo , Vedantham Harish
Published: September 2023

Studying blazar radio variability on timescales ranging from months to years provides information on the sub-parsec-scale structures of the jets, and the physics of the central active galactic nuclei. In this study, we focus on the radio variability of 1158 blazars observed at 15 GHz through the Owens Valley Radio Observatory Blazar Monitoring Program, where these sources have been observed about twice a week for over a decade. We investigate the dependence of the variability amplitudes and timescales, derived using a simple model fit to the structure function, on the milliarcsecond radio core sizes measured by Very Long Baseline Interferometry. The most compact sources exhibit larger variability amplitudes and shorter variability timescales than the more extended sources; this could be explained by light travel-time effects.
J2102+6015: a potential distant multimessenger?
Authors: Gurvits Leonid I. , Frey Sándor , Krezinger Máté , Titov Oleg , An Tao , Zhang Yingkang , Polnarev Alexander G. , Gabányi Krisztina É. , Perger Krisztina , Melnikov Alexey
Published: September 2023

We present and briefly discuss results of several studies of the source J2102+6015 with tentatively defined redshift z = 4.575 which demonstrates unusual properties in imaging and astrometric VLBI observations. Its properties might be considered as indications on the supermassive black hole binary which can be considered as a so far rare example of a high-redshift source of known electromagnetic and, possibly, predictable gravitational wave emissions.
Helicopter‐Based Ocean Observations Capture Broad Ocean Heat Intrusions Toward the Totten Ice Shelf
Authors: Nakayama Yoshihiro , Wongpan Pat , Greenbaum Jamin S. , Yamazaki Kaihe , Noguchi Tomohide , Simizu Daisuke , Kashiwase Haruhiko , Blankenship Donald D. , Tamura Takeshi , Aoki Shigeru
Published: September 2023

The recent discovery of warm ocean water near the Totten Ice Shelf (TIS) has increased attention to the Sabrina Coast in East Antarctica. We report the result of 6‐day helicopter‐based observations conducted during the 61st Japanese Antarctic Research Expedition (JARE61), revealing warm ocean water (0.5–1°C) occupying a large previously unsampled area of the Sabrina Coast (116.5°E−120°E) below 550–600 m. Along the TIS front, we observe modified Circumpolar Deep Water (mCDW) well above freezing (∼−0.7°C), consistent with previous work. We identify glacial meltwater outflow from the TIS cavity west of 116°E. No signs of mCDW intrusions toward the Moscow University Ice Shelf cavity are observed; however, those observations were limited to only two shallow (∼330 m) profiles. We also highlight the advantages of helicopter‐based observations for accessibility, speed, maneuverability, and cost‐efficiency. The combination of ship‐ and helicopter‐based observations using the JARE61 approach will increase the potential of future polar oceanographic observations.
Sounding of the Atmosphere Using Broadband Emission Radiometry (SABER): Instrument and Science Measurement Description
Authors: Esplin Roy , Mlynczak Martin G. , Russell James , Gordley Larry ,   The SABER Team
Published: September 2023

SABER (Sounding of the Atmosphere using Broadband Emission Radiometry) is a 10‐channel infrared radiometer that is one of four instruments on the NASA TIMED (Thermosphere‐Ionosphere‐Mesosphere Energetics and Dynamics) satellite mission to study the structure, energetics, chemistry, and dynamics of the Earth's mesosphere and lower thermosphere. Each of the ten SABER channels has a unique filter over its detector. The filter passes infrared radiation within a defined spectral region that optimizes the ability to derive temperature and constituent concentrations from the infrared radiance measurements. The TIMED spacecraft was launched into a 625 km circular polar orbit (74.1° inclination) via a Boeing Delta II rocket from Vandenberg Air Force Base on 7 December 2001. SABER continues to operate nominally and collect data routinely as it has for over 21 years. Nearly 2,200 peer‐reviewed journal articles have been published worldwide using SABER data. A list of these articles is included in Supporting Information S1 accompanying this paper. This paper presents a detailed technical description of the SABER instrument including major subsystems of the instrument and technical performance parameters. This paper comprehensively describes the instrument and its components and provides final instrument design and performance parameters. The motivation for this paper is to document this information permanently for future reference. The Space Dynamics Laboratory (SDL) of Utah State University designed, fabricated, and calibrated the SABER instrument in close collaboration with NASA Langley Research Center, Hampton University, and Global Atmospheric Technologies and Science (GATS).
Community‐Based Fire Management in East and Southern African Savanna‐Protected Areas: A Review of the Published Evidence
Authors: Croker Abigail R. , Woods Jeremy , Kountouris Yiannis
Published: September 2023

The introduction of fire suppression policies and expansion of exclusionary protected areas in East and Southern African savannas have engendered a wildfire paradox. Outside protected areas, livestock have replaced fire as the dominant fuel consumer. Inside their boundaries, wildfire intensity has increased due to accumulating flammable biomass. Community‐Based Fire Management (CBFiM) is recognized as an alternative fire management strategy to address the wildfire paradox and promote equitable fire governance across conservation landscapes. Yet, there has been little investigation into the implementation and effectiveness of CBFiM across East and Southern Africa's savanna‐protected areas. Here we employ a social‐ecological systems framework to develop a systematic map of the published literature on the framing and features of CBFiM in this context. We characterize the challenges and opportunities for their design and implementation, focusing on the relationship between governance systems and community participation in fire management. We find that CBFiM projects are commonly governed by the state and international non‐governmental organisations who retain decision‐making power and determine access to savanna resources and fire use. Existing CBFiM projects are limited to communal rangelands and are developed within existing Community‐Based Natural Resource Management programs prioritizing fire prevention and suppression. Planned CBFiM projects propose an exclusive early‐dry season patch mosaic burning regime to incorporate indigenous fire knowledge into modern management frameworks, but evidence of indigenous and local peoples' involvement is scarce. To provide equitable fire management, CBFiM projects need to address inequalities embedded in protected area governance and centralized suppression policies, and account for changing state‐society and intra‐society relations across the region.
Reconnection Rates at the Earth's Magnetopause and in the Magnetosheath
Authors: Pritchard K. R. , Burch J. L. , Fuselier S. A. , Genestreti K. J. , Denton R. E. , Webster J. M. , Broll J. M.
Published: September 2023

Reconnection electric fields and normalized reconnection rates (RRs) were determined with the four Magnetospheric Multiscale (MMS) spacecraft for 14 reconnection events on the dayside of the Earth's magnetosphere. Half of the events occurred at the magnetopause (MP) and the other half in the magnetosheath (MS). The RRs were determined by measurements of the reconnection electric field within electron diffusion regions. Since the reconnection electric field component is much smaller than the other components, special care had to be taken to eliminate contamination by the larger components. Normalized RRs between 0.02 and 0.48 were determined with average values in the range of theoretical predictions for steady‐state reconnection (0.1–0.2). Using measurements from individual MMS spacecraft, 20 normalized RRs were determined for the seven MP events with a mean of 0.14 and a standard deviation of 0.09. For the 27 RRs that were determined for the seven MS events, the normalized RRs had a mean of 0.16 and a standard deviation of 0.12. These results show variations of over an order of magnitude between the fastest and slowest RRs. However, when summed over all spacecraft, calculations suggest that the RR per event is relatively constant, as predicted theoretically. Searches for dependence of the normalized RR on local or solar‐wind parameters were inconclusive. However, we do find that for the MS events, the reconnection electric field showed a direct dependence on solar‐wind dynamic pressure.
The Global Variation of Low Ionosphere Under Action of Energetic Electron Precipitation
Authors: Chen Zhou , Xie Tingfeng , Li Haimeng , Ouyang Zhihai , Deng Xiaohua
Published: September 2023

The density in the D region is hard to observe on a large scale, because the density in this region is too low. In addition to solar radiation changes with a sinusoidal period of 24 hr, the energetic electron precipitation (EEP) is the major source for the ionospheric D region. In this study, we utilized observations from NOAA/MetOp satellites to derive the electron density profile from 60 to 150 km under the influence of EEP. It seems that the derived electron profile is roughly consistent with the observed one. Additionally, using above derived method of low ionospheric (D and E regions) electron profile based on the observations of NOAA/MetOp satellites, the actions of EEP on global ionosphere under different level of geomagnetic activity are analyzed. We find that EEP has a significant impact on the electron density in the altitude range from 60 to 90 km in the L ∼ 4.5–8 and MLT ∼ 9–14 regions, particularly during strong geomagnetic activity. A peak in Total Electron Content (TEC) was observed at MLT ∼ 11–12 and L ∼ 5.5–6, exhibiting an enhancement approximately 19.96 times higher than that observed during quiet periods. However, the effects of EEP decrease as altitude increases. The TEC enhancement at altitudes from 90 to 120 km during strong geomagnetic activity is like that at 60–90 km, but only about 2.08 times higher than that during quiet periods. In addition, only a weak increase is detected around midnight at altitudes from 120 to 150 km.
Spatial and Interannual Variability of Antarctic Sea Ice Bottom Algal Habitat, 2004–2019
Authors: Lim Stephanie M. , van Dijken Gert L. , Arrigo Kevin R.
Published: September 2023

In the Antarctic, sea ice algae use the highly dynamic sea ice as a platform for growth. Antarctic sea ice extent has recently been highly variable, first showing a slight increase and then a record decrease starting in 2016. We investigated the response of Antarctic ice algal habitat to variations in sea ice and other environmental forcings during 2004–2019. Combining an ice growth model, remote sensing and reanalysis data, and a radiative transfer model, we assessed whether light penetration to the bottom ice was sufficient for ice algal growth. Trends in the inputs over the 16 years were relatively small: there were no changes in ice thickness or bottom ice melt date, a 6.4% decrease in snow depth, a 1.2% decrease in incident light, and a 0.8°C decrease in air temperatures. Eighty‐one percent of the sea ice cover was habitable by ice algae for ≥14 days each year. The Antarctic has a larger extent and duration of potential ice algal habitat than the Arctic. Over time, the spatially averaged seasonal duration of habitat increased because a higher proportion of each pixel became habitable on average, compensating for the 2016–2019 reduction in sea ice extent. The spatial variability in potential habitat was strikingly high, even within geographic sectors. Bottom ice melt date (bloom termination) far surpassed other environmental factors in explaining variation (45%) in ice algal habitat on the 25 km scale. Because melt date depends on the ice‐atmosphere heat balance, Antarctic ice algal habitat may be highly sensitive to future climate changes.
Electrification Within Wintertime Stratiform Regions Sampled During the 2020/2022 NASA IMPACTS Field Campaign
Authors: Harkema Sebastian S. , Carey Lawrence D. , Schultz Christopher J. , Mansell Edward R. , Berndt Emily B. , Fierro Alexandre O. , Matsui Toshi
Published: September 2023

Two nor'easter events—sampled during the NASA Investigation of Microphysics and Precipitation for Atlantic Coast‐Threatening Snowstorms (IMPACTS) field campaign—were examined to characterize the microphysics in relation to the underlying electrification processes within wintertime stratiform regions. A theoretical model was developed to determine whether accretion or diffusion growth regimes were preferential during periods of greatest electrification. Model simulation with electrification parameterization was used to provide supplemental context to the physical processes of in‐cloud microphysics and electrification. The strongest electric fields (i.e., ∼80 V m−1 at 20 km) during the 2020 NASA IMPACTS deployment was associated with large non‐rimed ice crystals colliding with each other. During the 29–30 January 2022 science flight, the NASA P‐3 microphysical probe data demonstrated that non‐inductive charging was possible off the coastline of Cape Cod, Massachusetts. Later in the science flight, when the NASA P‐3 and ER‐2 were coordinating with each other, measured electric fields consistently were less than 8 V m−1 and electrification was subdued owing to reduced concentrations of graupel and large ice hydrometeors. Altogether, the in‐situ observations provide evidence for the non‐riming collisional charging mechanism and demonstrates that graupel and supercooled liquid water may not be necessary for weak electrification within wintertime stratiform regions. Model output from simulation of both events suggested that the main synoptic snowbands were associated with elevated hydrometeor snow charge density and electric fields.
Sensitivity of Burned Area and Fire Radiative Power Predictions to Containment Efforts, Fuel Density, and Fuel Moisture Using WRF‐Fire
Authors: Turney Francis A. , Saide Pablo E. , Jimenez Munoz Pedro A. , Muñoz‐Esparza Domingo , Hyer Edward J. , Peterson David A. , Frediani Maria E. , Juliano Timothy W. , DeCastro Amy L. , Kosović Branko , Ye Xinxin , Thapa Laura H.
Published: September 2023

Predicting the evolution of burned area, smoke emissions, and energy release from wildfires is crucial to air quality forecasting and emergency response planning yet has long posed a significant scientific challenge. Here we compare predictions of burned area and fire radiative power from the coupled weather/fire‐spread model WRF‐Fire (Weather and Research Forecasting Tool with fire code), against simpler methods typically used in air quality forecasts. We choose the 2019 Williams Flats Fire as our test case due to a wealth of observations and ignite the fire on different days and under different configurations. Using a novel re‐gridding scheme, we compare WRF‐Fire's heat output to geostationary satellite data at 1‐hr temporal resolution. We also evaluate WRF‐Fire's time‐resolved burned area against high‐resolution imaging from the National Infrared Operations aircraft data. Results indicate that for this study, accounting for containment efforts in WRF‐Fire simulations makes the biggest difference in achieving accurate results for daily burned area predictions. When incorporating novel containment line inputs, fuel density increases, and fuel moisture observations into the model, the error in average daily burned area is 30% lower than persistence forecasting over a 5‐day forecast. Prescribed diurnal cycles and those resolved by WRF‐Fire simulations show a phase offset of at least an hour ahead of observations, likely indicating the need for dynamic fuel moisture schemes. This work shows that with proper configuration and input data, coupled weather/fire‐spread modeling has the potential to improve smoke emission forecasts.
CLASP: CLustering of Atmospheric Satellite Products and Its Applications in Feature Detection of Atmospheric Trace Gases
Authors: Lee Tabitha , Wang Yuxuan
Published: September 2023

Satellite instruments have the most potential of capturing trace gas variability as they continually observe the atmosphere and its composition over wide regions. Yet the increasingly large data size of satellite products poses a challenge for their use as traditional data processing methods (e.g., averaging) may not be effective to extract the spatiotemporal variability without prior knowledge of an emission source's spatial and temporal behavior, such as location, time, and plume shape. Here, an agile clustering algorithm entitled CLustering of Atmospheric Satellite Products (CLASP) is presented to identify the spatiotemporal variability of trace gases captured in satellite observations. We find the knowledge discovery method for large data sets, clustering, is suited for identifying the variability of trace gases in satellite observations, as such CLASP is rooted in density‐based clustering methods. CLASP detects features from satellite observations and identifies their spatial, magnitude, and temporal axis leading to a better understanding of the spatiotemporal variability of atmospheric trace gases. To test the applicability of CLASP, the algorithm is applied to TROPOspheric Monitoring Instrument NO2 observations illustrating some of its different capabilities. Implementing CLASP for event identification, capturing plume variability, and source detection, CLASP identified wildfires, observed disruptions from COVID‐19 lockdown restrictions, and detected irregular emissions from oil and gas operations.
Unconventional immune cells in the gut mucosal barrier: regulation by symbiotic microbiota
Authors: Yoo Ji-Sun , Oh Sungwhan F.
Published: September 2023

The mammalian gut is the most densely colonized organ by microbial species, which are in constant contact with the host throughout life. Hosts have developed multifaceted cellular and molecular mechanisms to distinguish and respond to benign and pathogenic bacteria. In addition to relatively well-characterized innate and adaptive immune cells, a growing body of evidence shows additional important players in gut mucosal immunity. Among them, unconventional immune cells, including innate lymphoid cells (ILCs) and unconventional T cells, are essential for maintaining homeostasis. These cells rapidly respond to bacterial signals and bridge the innate immunity and adaptive immunity in the mucosal barrier. Here, we focus on the types and roles of these immune cells in physiological and pathological conditions as prominent mechanisms by which the host immune system communicates with the gut microbiota in health and diseases.
Prefrontal cortex astroglia modulate anhedonia-like behavior
Authors: Codeluppi S. A. , Xu M. , Bansal Y. , Lepack A. E. , Duric V. , Chow M. , Muir J. , Bagot R. C. , Licznerski P. , Wilber S. L. , Sanacora G. , Sibille E. , Duman R. S. , Pittenger C. , Banasr M.
Published: September 2023

Reductions of astroglia expressing glial fibrillary acidic protein (GFAP) are consistently found in the prefrontal cortex (PFC) of patients with depression and in rodent chronic stress models. Here, we examine the consequences of PFC GFAP+ cell depletion and cell activity enhancement on depressive-like behaviors in rodents. Using viral expression of diphtheria toxin receptor in PFC GFAP+ cells, which allows experimental depletion of these cells following diphtheria toxin administration, we demonstrated that PFC GFAP+ cell depletion induced anhedonia-like behavior within 2 days and lasting up to 8 days, but no anxiety-like deficits. Conversely, activating PFC GFAP+ cell activity for 3 weeks using designer receptor exclusively activated by designer drugs (DREADDs) reversed chronic restraint stress-induced anhedonia-like deficits, but not anxiety-like deficits. Our results highlight a critical role of cortical astroglia in the development of anhedonia and further support the idea of targeting astroglia for the treatment of depression.
Geometric alignment of aminoacyl-tRNA relative to catalytic centers of the ribosome underpins accurate mRNA decoding
Authors: Girodat Dylan , Wieden Hans-Joachim , Blanchard Scott C. , Sanbonmatsu Karissa Y.
Published: September 2023

Accurate protein synthesis is determined by the two-subunit ribosome’s capacity to selectively incorporate cognate aminoacyl-tRNA for each mRNA codon. The molecular basis of tRNA selection accuracy, and how fidelity can be affected by antibiotics, remains incompletely understood. Using molecular simulations, we find that cognate and near-cognate tRNAs delivered to the ribosome by Elongation Factor Tu (EF-Tu) can follow divergent pathways of motion into the ribosome during both initial selection and proofreading. Consequently, cognate aa-tRNAs follow pathways aligned with the catalytic GTPase and peptidyltransferase centers of the large subunit, while near-cognate aa-tRNAs follow pathways that are misaligned. These findings suggest that differences in mRNA codon-tRNA anticodon interactions within the small subunit decoding center, where codon-anticodon interactions occur, are geometrically amplified over distance, as a result of this site’s physical separation from the large ribosomal subunit catalytic centers. These insights posit that the physical size of both tRNA and ribosome are key determinants of the tRNA selection fidelity mechanism.