bluuebunny/crossref_metadata_2025 huggingface dataset:
Identifying and Classifying Shared Selective Sweeps from Multilocus Data
Authors: Harris Alexandre M , DeGiorgio Michael
Published: March 2020

Positive selection causes beneficial alleles to rise to high frequency, resulting in a selective sweep of the diversity surrounding the selected sites. Accordingly, the signature of a selective sweep in an ancestral population may still remain in its descendants. Identifying signatures of selection in the ancestor that are shared among its descendants is important to contextualize the timing of a sweep, but few methods exist for this purpose. We introduce the statistic SS-H12, which can identify genomic regions under shared positive selection across populations and is based on the theory of the expected haplotype homozygosity statistic H12, which detects recent hard and soft sweeps from the presence of high-frequency haplotypes. SS-H12 is distinct from comparable statistics because it requires a minimum of only two populations, and properly identifies and differentiates between independent convergent sweeps and true ancestral sweeps, with high power and robustness to a variety of demographic models. Furthermore, we can apply SS-H12 in conjunction with the ratio of statistics we term H2Tot and H1Tot to further classify identified shared sweeps as hard or soft. Finally, we identified both previously reported and novel shared sweep candidates from human whole-genome sequences. Previously reported candidates include the well-characterized ancestral sweeps at LCT and SLC24A5 in Indo-Europeans, as well as GPHN worldwide. Novel candidates include an ancestral sweep at RGS18 in sub-Saharan Africans involved in regulating the platelet response and implicated in sudden cardiac death, and a convergent sweep at C2CD5 between European and East Asian populations that may explain their different insulin responses.
AKTIVITAS DAN KARAKTERISASI ENZIM PROTEASE ISOLAT Bacillus sp. (UJ132) SECARA KUALITATIF DAN KUANTITATIF
Authors: Sumardi Sumardi , Farisi Salman , Ekowati Chiristina Nugroho , Diana Milsa Solva
Published: March 2020

Bakteri penghasil enzim protease memiliki kemampuan untuk melakukan bioremediasi limbah protein. Penelitian ini dilakukan untuk mengetahui aktivitas dan karakterisasi enzim protease dari isolat Bacillus sp. (UJ132) yang diisolasi dari udang pasir (Metapenaeus affinis) di kawasan hutan mangrove Desa Margasari, Lampung Timur. Uji aktivitas enzim dilakukan secara kualitatif dan kuantitatif. Karakterisasi enzim meliputi penentuan suhu dan pH optimum, pengaruh ion logam, serta penentuan Km dan Vmaks. Dari hasil percobaan diketahui bahwa enzim protease dihasilkan pada waktu produksi optimum 18 jam dengan aktivitas protease sebesar 0,09 U/mL. Suhu optimum enzim ini yaitu pada suhu 50°C yang menghasilkan aktivitas sebesar 0,08 U/mL. Enzim protease ini mempunyai kondisi optimum pada pH 5 dengan nilai aktivitas 0,09 U/mL. Semua ion logam (Ca2+, Mn2+, Cu2+, Mg2+) berfungsi sebagai inhibitor kecuali ion Fe3+ yang berfungsi sebagai aktivator pada konsentrasi 1 mM dan 5 mM. EDTA dengan konsentrasi 1 mM dan 5 mM berfungsi sebagai inhibitor pada enzim protease isolat UJ132. Nilai Vmaks enzim protease 0,33 U/mL sedangkan Km senilai 4,59 mg/mL substrat, enzim ini mempunyai afinitas yang tinggi terhadap substrat.Shrimp farming produces protein wastes which mainly come from the remnants of given feed and excreta (feces) of shrimp. Bacteria known to possess protease enzymes have the ability to solve this protein waste problem in the shrimp farming industry. This study was conducted to determine the production and characterization of protease enzyme from Bacillus sp. (UJ132) isolated from the mangrove forest area of Margasari Village of Lampung Timur. The enzyme activity test was done qualitatively and quantitatively. The objectives of this study were to determine the optimum production of the enzymes and observe their characteristics, including determining the temperature and optimum pH, the effect of several metal ions, as well as Km and Vmax. The experimental results revealed that the protease enzyme had an optimum time of 18 hours of protease activity as much as 0.09 U/mL. The optimum temperature of this enzyme was 50°C which produced an activity of 0.08 U/mL. This protease enzyme has an optimum working condition at pH 5 with an activity value of 0.09 U/mL. All metal ions (Ca2+, Mn2+, Cu2+, Mg2+) acted as inhibitors except Fe3 + ions which acted as activators at concentrations of 1 mM and 5 mM. EDTA with a concentration of 1 mM and 5 mM served as an inhibitor of UJ132 isolate protease enzyme. The value of Vmax of the protease enzyme was 0.33 U/mL while Km was 4.59 mg/mL suggesting that this enzyme has a high affinity with the substrate.
Implementation of clinical decision support system for anticoagulant prescribing for patients with deep vein thrombosis
Authors: Chernov Anton A. , Kleymenova E. B. , Sychev Dmitry A. , Yashina Liubov P. , Nigmatkulova Maria D. , Otdelenov Vitaly A. , Yashina L. P.
Published: March 2020

Background: Physicians adherence to recommendations for appropriate antithrombotic therapy of venous thromboembolism (VTE) can reduce the risk of recurrent VTE, pulmonary hypertension, bleeding and other adverse events. Clinical decision support systems (CDSS) are shown to increase physicians adherence to clinical guidelines.
Aims: To assess effectivenes and safety of CDSS for anticoagulant prescribing for inhospital patients with VTE.
Methods: A prospective cohort study was conducted in a Moscow general hospital from 06.30.2017 to 06.23.2018 to compare physicians compliance with clinical guidelines for DVT anticoagulant therapy, the rate of drug errors and direct costs of anticoagulant therapy before and after CDSS implementation (55 patients in control group and 49 in experimental group).
Results: The rate of anticoagulant prescribing for patients with DVT did not alter significantly after CDSS implementation (96% compared with 91% before CDSS), but physicians compliance with recommendations on anticoagulant dosage increased from 32.7% to 73.5% (p = 0.0003) with corresponding decrease in the rate of anticoagulant prescribing errors from 1.35 to 0.65 per 1 patient (p = 0.0005). The length of stay and hemorrhagic complication rate did not differ between control and experimental groups. LMWH replacement with new oral anticoagulants has reduced the cost of anticoagulant therapy for 1 patient from 11.800 rubles (IQR = 7000) to 5.430 rubles (IQR = 5700) (p 0.005).
Conclusions: СDSS can increase physicians adherence to recommended anticoagulant therapy for patients with DVT: to prevent unreasonable under-/overdosing or prolongation of anticoagulant therapy. CDSS for DVT drug therapy can be economically feasible.
The European Medicines Agency Review of Gilteritinib (Xospata) for the Treatment of Adult Patients with Relapsed or Refractory Acute Myeloid Leukemia with anFLT3Mutation
Authors: Tzogani Kyriaki , Røshol Hilde , Olsen Helga Haugom , Aas Ida B. , Dalhus Marianne Løiten , Håkonsen Gro Dahlseng , Nilssen Laila Sortvik , Lindberg Vibeke , Økvist Mats , Bolstad Bjørg , Rogovska Irēna , Karpova Natalja , Enzmann Harald , Gisselbrecht Christian , Pignatti Francesco
Published: March 2020

On October 24, 2019, a marketing authorization valid through the European Union (EU) was issued for gilteritinib monotherapy for adult patients who have relapsed or refractory acute myeloid leukemia (AML) with an Fms-like tyrosine kinase 3 (FLT3) mutation. Gilteritinib inhibits FLT3 receptor signaling and proliferation in cells exogenously expressing FLT3 including FLT3 internal tandem duplication (ITD), FLT3 D835Y, and FLT3 ITD D835Y, and it induced apoptosis in leukemic cells expressing FLT3 ITD. The recommended starting dose of gilteritinib is 120 mg (three 40 mg tablets) once daily. Gilteritinib was evaluated in one, phase III, open-label, multicenter, randomized study of gilteritinib (n = 247, gilteritinib arm) versus salvage chemotherapy (n = 124, salvage chemotherapy arm) in patients with relapsed or refractory AML with FLT3 mutation. Overall survival (OS) was statistically significantly different between the two groups with a median OS of 9.3 months in the gilteritinib arm compared with 5.6 months for salvage chemotherapy (hazard ratio, 0.637; 95% confidence interval, 0.490–0.830; p = .0004 one-sided log-rank test). The most common adverse reactions with gilteritinib treatment were blood creatine phosphokinase increase, alanine aminotransferase increase, aspartate aminotransferase increase, blood alkaline phosphatase increase, diarrhea, fatigue, nausea, constipation, cough, peripheral edema, dyspnea, dizziness, hypotension, pain in extremity, asthenia, arthralgia, and myalgia. The objective of this article is to summarize the scientific review of the application leading to regulatory approval in the EU.

Implications for Practice

Xospata was approved in the European Union as monotherapy for the treatment of adult patients with relapsed or refractory acute myeloid leukemia (AML) with an Fms-like tyrosine kinase 3 (FLT3) mutation. Gilteritinib resulted in a clinically meaningful and statistically significant improvement of overall survival compared with salvage chemotherapy. At the time of the marketing authorization of gilteritinib, there were no approved standard therapies specifically for adult patients diagnosed with relapsed or refractory AML with FLT3 mutation. In terms of safety, the overall accepted safety profile was considered manageable.
Intity, Reality, Expertise in System of Humanitarian Science Methodology
Authors: Atanov Andrei
Published: March 2020

The article analyses such forms of obtaining and processing information in the system of scientific and non-scientific knowledge as expert evaluation and expertise. The context of concepts «knowledge» and «cognition» evolves restrictions to the fields of using an expert approach. The concept «expert evaluation» is structured in correlation with conceptual basics implemented in the institutional approach. For analyzing the concepts «expert evaluation» and «experstise», the methodology of psychological and philosophical siences is used: psychoanalytical analysis, analysis, synthesis, modelling in conceptual basics of the structural method. The article creates a logical consequence of methodological devices in the system of humanitarian sciences that allow to obtain new results. The ground of using of the mentioned methodological approaches is building an integral сultural and semantic space that allow to conceptually determine the institutional processes.
Current State and Main Trends of Foreign Trade Development in Far Eastern Federal District
Authors: Sukhodolov Alexander , Sukhodolov Yakov
Published: March 2020

The article examines the current specificity of foreign trade ties of the Far Eastern Federal District. It presents a brief analysis of dynamics of the volumes and commodity structure of the export-import operations of the Far Eastern Federal District. At present, of specific significance for the regions of the Far East and Siberia is search for tolls of modernizing the economy with purpose of transition to innovative development. Foreign trade can be a perspective direction of socio-economic development of Russia’s Far East. Far Eastern Federal District is export-oriented, but in the export commodity structure the mineral raw groups of commodities prevail, which decreases its positive effect. Expansion of trade-economic and investment cooperation with the countries of the Asian-Pacific region in the field of developing processing industries and machine building oriented at increasing the depth of mineral resources processing and growth of the ready-made products export can become the basis of sustainable development of the Far East.
Transformation of Bank's Business Model in Terms of Digital Economy
Authors: Bubnova Yulia
Published: March 2020

Information technology, artificial intelligence penetrate into the banking sector, making it more mobile and flexible. Needs and preferences of customers, ways of providing financial services are changing. IT-companies that offer traditional banking products in a new, present day’s format are entering the financial services market. Banks have to invest huge amounts of money in developing banking innovations in order to remain in demand. All this requires banks to change not only the ways of providing their services and communication with customers, but also the qualitative restructuring of operational processes, methods and approaches to their management, corporate culture. The article examines the changes in the main components of the banking management system under the influence of digital technologies: the customer segment, the operating processes and the business model. It pays particular attention to the need of changing the existing banking business mode. It summarizes the main financial technologies that allow to transform banking business in accordance with the requirements of the digital economy.
SINIF ÖĞRETMENLERİ SAYI VE ŞEKİL ÖRÜNTÜLERİNİ NASIL ÖĞRETİYORLAR? İLKOKUL DÖRDÜNCÜ SINIF ÖRNEĞİ
Authors: DOĞAN TEMUR Özlem , TURGUT Sedat
Published: March 2020

Bu araştırmada sayı ve şekil örüntülerinin ilkokul dördüncü sınıf düzeyinde sınıf öğretmenleri tarafından nasıl öğretildiğini ve öğretmenlerin öğretim süreçlerini ortaya koymak, yapılan uygulamaları konu ve öğretimin bileşenleriyle birlikte ele alarak değerlendirmek amaçlanmıştır. Araştırma durum çalışması olarak tasarlanmıştır. Araştırmanın çalışma grubunu Millî Eğitim Bakanlığı’na bağlı okullarda görev yapmakta olan iki sınıf öğretmeni ve bu öğretmenlerin öğretim yaptıkları sınıflardaki toplam 39 dördüncü sınıf öğrencisi oluşturmaktadır. Her bir sınıf öğretmeni sayı ve şekil örüntülerinin öğretimiyle ilgili ders planları hazırlamış ve hazırladıkları planları öğretim yaptıkları sınıflarda üçer ders saati uygulamışlardır. Veriler video kaydı aracılığıyla toplanmıştır. Video kayıtlarının yazıya geçirilmesiyle elde edilen verilerin analizinde içerik analizi tekniği kullanılmıştır. Araştırmada sınıf öğretmenlerinin örüntü konusunun öğretim sürecinde öğrencilerine verdikleri görevlere ait yönerge oluşturmakta ve bu yönergeleri sunmakta zorlandıkları görülmüştür. Öğretim sürecinde öğretmenlerin muhakeme gerektirecek görevleri kullandıkları fakat bazı durumlarda yetersiz kaldıkları ve etkili dersler işleyemedikleri belirlenmiştir. Öğretim sürecinde öğretmenler genel olarak düşündürücü ve problem çözmeye dayalı sorular yerine rutin ve tablo okumaya dayalı sorular kullanmışlardır. Öğretmenler genelleme gerektiren görevleri iyi organize edememişlerdir. Fakat tablolar ve örüntü içeren farklı görevlerin kullanılması öğrencilerin genellemeler yapmalarına fırsatlar sunmuştur.
ALTINCI SINIF ÖĞRENCİLERİNİN MATEMATİĞE YÖNELİK TUTUMLARINI ETKİLEYEN FAKTÖRLER: BİR YAPISAL EŞİTLİK MODELİ (YEM) YAKLAŞIMI
Authors: KAYA Deniz
Published: March 2020

Araştırma altıncı sınıf
öğrencilerinin matematiğe yönelik tutumlarını etkileyen birtakım faktörlerin
doğrudan, dolaylı ve toplam etkilerini belirlemek için tasarlanmıştır. Bu
doğrultuda algılanan ebeveyn etkisi, matematik öğrenme yaklaşımları,
matematiksel ilişkilendirme öz-yeterlik, temel psikolojik ihtiyaçlar ve
matematiğe yönelik tutum arasındaki açıklayıcı ve yordayıcı ilişkiler
incelenmiştir. Tarama modelinin benimsendiği araştırmanın çalışma grubunu İzmir
şehir merkezinde yer alan bir devlet ortaokulundaki 416 öğrenci
oluşturmaktadır. Yaşları 10-12 aralığında değişen öğrencilerin %54,3’ü (n=226)
kız, %45,7’si (n=190) erkektir. Araştırmada veri toplama araçları olarak;
Algılanan Ebeveyn Etkisi, Matematik Öğrenme Yaklaşımları, Matematiksel
İlişkilendirme Öz-Yeterlik, Temel Psikolojik İhtiyaçlar ile Matematiğe Yönelik
Tutum ölçekleri kullanılmıştır. Toplanan veriler dışsal ve içsel değişkenler
arasındaki doğrudan ve dolaylı nedenselliği yapısal denklemler aracılığı ile
ortaya koymak için yapısal eşitlik modellerinden Path (yol) ile analiz edilmiştir.
Elde edilen bulgulara göre, matematiğe yönelik tutumu matematiksel
ilişkilendirme öz-yeterlik, temel psikolojik ihtiyaçlar ve matematik öğrenme
yaklaşımları doğrudan, algılanan ebeveyn etkisi de dolaylı olarak etkilemektedir.
Matematiğe yönelik tutumu doğrudan etkileyen değişkenler toplam varyansın
%76’sını açıklamaktadır. Matematiğe yönelik tutuma (R2=0,76; f2=1,36)
ait yapısal eşitliklerin etki değerleri ise geniş düzeydedir. Öğrencilerde
matematiğe yönelik olumlu algı oluşturmada matematiksel ilişkilendirme öz-yeterlik
düzeylerinin artırılması, temel psikolojik ihtiyaçlarının karşılanması, uygun
öğrenme yaklaşımlarının benimsenmesi ve olumlu ebeveyn etkisinin oluşturulması
öneri olarak sunulmuştur.
OKUL ÖNCESİ ÖĞRETMENLERİNİN TEKNOPEDAGOJİK YETERLİKLERİNİN BELİRLENMESİ
Authors: ÖZDURAK SINGIN Rabia Hürrem , GÖKBULUT Bayram
Published: March 2020

İçerisinde bulunduğumuz dijital çağda öğrencilere 21.yüzyıl becerilerin yanı sıra dijital vatandaşlığın kazandırılması büyük önem arz etmektedir. Yüz yüze eğitimin başlangıcı olarak kabul edilen okul öncesi eğitimde teknolojinin kullanılması yönündeki görüşler gün geçtikçe artmaktadır. Yapılan çalışmalar sayesinde teknolojinin etkili ve doğru biçimde kullanıldığında fırsatları arttırdığı, ancak yanlış kullanıldığında zorlukları beraberinde getirdiği ve fiziksel aktivite düzeyinde azalmaya bağlı obezite gibi olumsuz etkiler yaratabileceği bilinmektedir. Bu nedenle okul öncesi öğretmenlerinin teknoloji, pedagoji ve alan bilgisinin birlikte kullanıldığı Teknopedagojik alan bilgisine diğer öğretmenlerden daha fazla ihtiyaç duyduğu düşünülmektedir. Bu çalışmada, okul öncesi öğretmenlerin Teknolojik Pedagojik Alan Bilgisi yeterliklerinin belirlenmesi amaçlanmıştır. Yapılan bu betimsel çalışma, Ankara’da okul öncesi öğretmeni olarak Milli Eğitim Müdürlüğü’ne bağlı okullarda görev yapan 1169 öğretmen ile yürütülmüştür. İlişkisel tarama modeli kullanılarak öğretmenlerin Teknopedagojik yeterlilikleri irdelenmiştir. Çalışmaya katılan öğretmenlerde Teknopedagojik yeterlilikleri eğitim düzeyi (lisans ve yüksek lisans) ve mesleki kıdeme göre farklılık gösterip göstermediği sorgulanmış, elde edilen verilerin analizleri sonucunda öğretmenlerin Teknopedagojik yeterliliklerinin yüksek düzey olduğu görülmüştür. Okul öncesi öğretmenlerinin lisans ve yüksek lisans yapmış olmaları ile mesleki kıdemlerinin Teknopedagojik yeterliliklerine etkisinin olmadığı görülmüştür.
SOSYAL BİLGİLER ÖĞRETİMİNDE TOPLUMSAL HAFIZA: AHISKA TÜRKLERİ HAFIZASI PROJESİ ÖRNEĞİ
Authors: İNEÇ Zekeriya Fatih
Published: March 2020

Bu çalışmanın amacı sosyal bilgiler dersinde kullanılabilecek internet tabanlı toplumsal bir hafıza uygulaması oluşturmaktır. Ayrıca sosyal bilgiler öğretmenlerinin uygulamaya ilişkin görüşlerini belirlemektir. Ahıskalı Türkler ve yaşadıkları sürgünler konusunda bilimsel bir literatür mevcut olmasına karşın hafıza niteliği olan bir çalışma ülkemizde bulunmamaktadır. Bu çerçevede araştırmacı tarafından ADDIE (Analiz, Tasarım, Geliştirme, Uygulama ve Değerlendirme) öğretim tasarımı modeli ile geo-medya teknolojisi kullanılarak toplumsal bir hafıza uygulaması (Ahıska Türkleri Hafızası Projesi - ATHP) geliştirilmiştir. ATHP’nin veri tabanını oluşturmak için nitel araştırma yöntemlerinden anlatı tekniğinden yararlanılmıştır. Bunun için sözlü tarih çalışması yürütülmüştür. Veri elde etmek için amaçlı örnekleme tekniklerinden benzeşik örnekleme tekniği ile sekiz Ahıskalı Türk belirlenmiştir. ATHP’nin değerlendirilmesi içinse nitel araştırma yöntemlerinden bütüncül çoklu durum çalışması yürütülmüştür. Amaçlı örnekleme yöntemlerinden maksimum çeşitlilik yöntemi ile dokuz sosyal bilgiler öğretmeni belirlenmiştir. Bu çerçevede elde edilen veriler içerik analizi ile değerlendirilmiştir. Araştırma sonucunda sosyal bilgiler öğretmenlerinin görüşlerinden elde edilen bulgular, ATHP’nin toplumsal bir hafıza oluşturma amacının ana ve doğru kaynağa ulaştırma, hafızayı canlı tutma ve ülkü birliğini sağlama şeklinde olduğunu; sosyal bilgiler derslerinde ATHP’nin kullanımının değer öğretimine, öğretim programına ve programın genel kazanımlarına uygun olduğunu; ATHP’nin güçlü yönlerinin ilk elden kaynakların paylaşımı, beceri eğitimi ile değer öğretimine imkan verdiğini; ATHP’nin zayıf yönlerinin ise örneklemin ve ara yüzün sınırlı iken, dildeki morfolojik farklılıkların ve içeriğin fazla olduğunu göstermektedir. ATHP’nin işlevselliğinin artırılması içinse kurumlar arası iş birliğinin, geniş kitlelere ulaşılmasının ve içeriğin genişletilmesinin gerektiği sonucu tespit edilmiştir. Bu çalışma ile ATHP, geo-medya teknolojisi üzerine kurulan ilk toplumsal hafıza çalışması olmuştur. Araştırmanın sonunda araştırmacılara bazı önerilerde bulunulmuştur.
ORTAOKUL ÖĞRENCİLERİNİN ‘ETKİLİ ÖĞRETİM VE ETKİLİ ÖĞRETMEN DAVRANIŞLARINA’ İLİŞKİN GÖRÜŞLERİ
Authors: ASLAN Osman , KILIÇ Durmuş
Published: March 2020

Başarılı bir eğitimin en önemli anahtarı öğretmendir. Eğitimin kalitesinde, öğretmenin etkinliği belirleyici rol oynamaktadır. Geleneksel eğitim anlayışının kaybolmaya yüz tuttuğu günümüz dünyasında hem öğrencinin hem de öğretmenin eğitim sürecindeki rolü artık değişmektedir. Değişen rollerle birlikte öğretmene düşen en önemli görev ise etkili bir öğrenme ortamı sunmak için gerekli olan davranışlar ortaya koymaktır. Etkili öğretmen davranışlarının incelendiği bu çalışmanın temel amacı ‘ortaokul öğrencilerin etkili öğrenme ve etkili öğretmen davranışlarına ilişkin görüşlerini’ araştırmaktır. Nicel araştırma yöntemi kullanılarak tasarlanan bu araştırma, tarama deseni olarak yapılandırılmış ve kesitli araştırma türü kullanılmıştır. Çalışmada veriler, Tokat merkezde eğitime devam eden 611 ortaokul öğrencisinden, ‘Etkili Öğrenme ve Etkili Öğretmen Davranışları’ başlıklı üçlü likert tipi ölçek kullanılarak elde edilmiştir. Elde edilen veriler SPSS programı ile frekans, yüzdelik dilim ve puan ile ifade edilmiş ve yorumlanabilir hale getirilmiştir. Bunun yanında Mann-Whitney U ve Kruskal Wallis Testi ile analiz edilerek, cinsiyet ve sınıf seviyelerine göre farklılıklarına bakılmıştır. Çalışmanın sonucunda, öğrencilere göre öğretmenler genel olarak etkili öğretimi destekleyecek nitelikte dersi sunmakta ve etkili öğretmen davranışları ortaya koymaktadırlar. Ayrıca kız öğrenciler, erkek öğrencilere nazaran, öğretmenlerin ders işleme stratejilerini daha etkili bulmaktadırlar.
SORUŞTURMAYA DAYALI FEN ÖĞRETİMİNİN 5. SINIF ÖĞRENCİLERİNDE ÖZ DÜZENLEME BECERİLERİ GELİŞİMİNE ETKİSİ
Authors: ATUN Tuğba , BAYRAM Zeki
Published: March 2020

Bu araştırma, soruşturma yaklaşımına dayalı fen öğretiminin 5. sınıf öğrencilerinin öğrenmeye yönelik öz düzenleme becerilerine etkisini ortaya koymak amacıyla karma yöntem kullanılarak yürütülmüştür. Araştırmanın çalışma grubunu, 5. sınıf öğrencileri (n=80) oluşturmuştur. Çalışmanın yürütüldüğü dört şubeden 2’si deney diğer 2’si kontrol grubu olarak belirlenmiştir. Araştırmada “Öğrenmede Motive Edici Stratejiler Ölçeği (ÖMSÖ)” ve araştırmacı tarafından hazırlanan “görüşme formu” ölçme aracı olarak kullanılmıştır. Deney grubunda soruşturma yaklaşımıyla ders yapılırken kontrol grubuna geleneksel yöntemle toplam 20 ders saati uygulama yapılmıştır. Araştırmanın verileri t-testi ve içerik analizi ile değerlendirilmiştir. Sonucunda deney grubu öğrencilerinde öz düzenleme becerilerinden “yardım arama stratejisi”, “çaba düzenleme stratejisi”, “öz yeterlik algısı” alt boyutlarında anlamlı fark bulunurken “zaman ve çalışma ortamını düzenleme stratejisi” ile “bilişüstü öz düzenleme” stratejilerinde anlamlı bir fark bulunamamıştır. Sonuç olarak, soruşturma yaklaşımına dayalı uygulamaların gerçekleştirildiği sınıf ortamında öğrenmeye yönelik bazı öz düzenleme becerilerinin gelişebileceği görülmüştür.
ÖĞRETMENLERİN ÖZNEL KARİYER BAŞARILARINA İLİŞKİN ALGILARI: BİR KARMA YÖNTEM ÇALIŞMASI
Authors: DİLEKÇİ Ümit , SEZGİN NARTGÜN Şenay
Published: March 2020

Bu araştırmanın amacı, 2018-2019 eğitim ve öğretim yılında Bolu il merkezindeki okul türlerinin tümünde görev yapan öğretmenlerin öznel kariyer başarılarına ilişkin algılarını ortaya çıkarmak ve bu algıları çeşitli değişkenler açısından incelemektir. Karma yöntem desenlerinden biri olan sıralı açıklayıcı desenin kullanıldığı araştırmada nicel veriler, Öznel Kariyer Başarısı Ölçeği (Budak & Gürbüz, 2017) kullanılarak toplanılmıştır. Bolu merkez ilçedeki 94 resmî okulda görev yapan 3127 öğretmenden oluşan araştırma evreni içerisinden tesadüfî örnekleme yöntemiyle seçilen 24 resmî okulda görev yapan 512 öğretmenden elde edilen nicel veriler, öncelikle güvenirlik analizine tabi tutulmuş olup Cronbach’s alpha iç tutarlılık katsayıları (α=.808 ile α=.945 arasında) nicel verilerin analiz için güvenilir olduğunu göstermiştir. Non-parametrik testler kullanılarak yapılan nicel analizlerin sonuçlarına göre; öğretmenlerin öznel kariyer başarılarına ilişkin görüşleri “kısmen katılıyorum” düzeyindedir. Ölçeğin boyutları arasında en yüksek aritmetik ortalamanın İşin Anlamlılığı boyutunda, en düşük aritmetik ortalamanın Tatmin boyutunda olduğu tespit edilmiştir. Öğretmenlerin medeni durum değişkeninde anlamlı bir fark ortaya çıkmazken; cinsiyet, görev yapılan okul türü, mesleki kıdem ve öğrenim durumu değişkenlerinde anlamlı bir fark ortaya çıkmıştır. Nicel analiz sonucunda ortaya çıkan anlamlı farkları derinlemesine incelemek için araştırmada nitel yöntem kullanılmıştır. Durum çalışması deseninde devam eden araştırmada, nitel veri toplama aracı olarak araştırmacılar tarafından ölçme aracının içeriğine uygun olarak hazırlanan yarı yapılandırılmış “Öğretmen Görüşme Formu” kullanılmıştır. Nitel veriler, amaçlı örneklem yöntemiyle seçilen 32 öğretmenden elde edilmiştir. Elde edilen nitel veriler, betimsel analiz yöntemiyle analiz edilmiş ve bu yöntemle nicel sonuçların altında yatan gerekçelere ulaşılmaya çalışılmıştır.
The concept of criminal procedural legal relations: definition of concept
Authors: Vinnychenko V.
Published: March 2020

The concept of criminal procedural legal relations in the context of modern globalism of criminal proceedings is considered in the article. Scientific approaches to definition of concept of legal relations, subject of criminal procedural law, method of criminal procedural law are investigated. The purpose of the article is to define the concept of criminal procedural legal relations under modern criminal proceedings. The author is investigated: Approaches to defining the concept of legal relations and Criminal procedural legal relations; Subject of criminal procedural law and method of criminal procedural law. During the research, a critical analysis of the mentioned scientific material is made and its own scientific approach to the definition of the criminal procedural legal relations is developed. During the copyright it is investigated a number of methods of scientific cognition, in particular, how: the method of scientific formalization; Axiomatic method; Hypoolytic-Deduktive method. The concept of the theory of Law on definition of notion and signs of legal relations was investigated, the analysis of these concepts was made and the concept of criminal procedural legal relations was chosen. The concept of criminal procedural legal relations provided by Ukrainian scientists and the critically-critical analysis of these concepts is investigated. It is given that existing approaches are not correct for modern legal reality and cannot be flexible in the face of progressive globalized development of the modern criminal procedural law. Scientific approaches to the subject of criminal procedural law as signs of criminal procedural legal relations are investigated. Scientific approaches to definition of criminal procedural law method as signs of criminal procedural legal relations are investigated. The analysis of the criminal procedural legislation and precedents of the European Court of Human Rights as a source of international public law is carried out. Generalized and scientifically deduction method output the concept of criminal procedural legal relations, which may be applied under the conditions of modern globalized criminal proceedings. The study has an interdisciplinary character. The author conducts research using the scientific base of Globalistics, Furturilogy, international relations.
Problems of determining the admissibility and appropriateness of digital (electronic) evidence in criminal proceedings
Authors: Metelev O.
Published: March 2020

The development of information technology, along with its indisputable advantages, has brought to our lives a number of negative phenomena related to the illegal use of computers and telecommunications. However, the issue of using digital information as evidence in the criminal procedural legislation of Ukraine remains almost unsettled, in particular, the place of digital evidence in the system of procedural sources of evidence (digital evidence is difficult to unambiguously attribute to material evidence or documents) remains unclear. Criminal proceedings raise problems regarding the correct assessment of digital (electronic) evidence for their identity and admissibility, which certainly does not contribute to the effective use of digital technologies and sources of information in national proceedings. The purpose of the article is to research the problematic issues of determining the appropriateness and admissibility of digital (electronic) evidence during criminal proceedings, as well as to identify and disclose individual principles for their proper procedural evaluation. The research deals with the current state of theoretical studies of the issue of the appropriateness and admissibility of digital evidence both in Ukrainian criminal procedure science and abroad. The peculiarities of the requirements for the assessment of traditional evidence and digital evidence in criminal proceedings are analyzed. The author identifies the features of obtaining (collecting) digital evidence, given their intangible nature, with a view to their further positive evaluation by admissibility and appropriateness criteria. Taking into account the international experience, the author concludes that there is a need to distinguish separate principles of admissibility and availability for digital evidence, revealing their content. The urgent need to settle this issue, both at the legislative level and through appropriate judicial clarification, is substantiated. It is emphasized that in view of the specific nature of digital (electronic) evidence to ensure their authenticity and reliability in criminal proceedings is associated with the promptness of investigative actions, mandatory involvement of an expert, professional training of all subjects of evidence and steady adherence to recommendations for working with digital evidence.
Between me, my younger self and the whole world: letters to one's younger self as epistolary genre
Authors: Alyeksyeyeva Iryna
Published: March 2020

The research treats letters to one’s younger (usually teen) self posted on the Internet as epistolary genre marked with peculiar linguistic and pragmatic features. Though the letters to one’s self imply intrapersonal communication, i.e. the sender is identical to the addressee, it is not how the sender perceives the situation, which is revealed by the use of pronouns (I for the sender and you for the younger self). However, these two may merge and then we appears to refer to the author’s younger and current selves. Another feature of the letters is roles assumed by the addressors. They may occur as a mentor to their rebellious and anxious younger self, which correlates with the purpose of the letter – giving advice. Alternatively, the authors may position themselves as omniscient fortune-tellers who step in in times of trouble to offer support to their teen self by telling what is there to come. Each of the two roles and purposes correlates with specific language means. The mentor role turns the letter into a lesson where the Imperative Mood prevails. The role of a fortune-teller transforms the letter into an autobiographical sketch told in a bizarre way: the author shifts past events into the future with the help of deictic markers (e.g., today, this) and tenses (e.g., future tenses or their synonyms such as constructions to be about to and to be going to). The letters to one’s younger self that contain an autobiographical component provide the researcher with an insight into the process of identity construction, since they show how one endows identity with continuity and bridge the divide between one’s teen and adult selves. In addition, the letters meant as advice deliver the culture specific idea of what ‘a good life’ is: they are written to guide their actual intended audience, i.e. Internet (teen) users, in modern society and inform them of true values and right choices.
The Intensity of Ground Motions from Induced Earthquakes with Implications for Damage Potential
Authors: Atkinson Gail M.
Published: March 2020

The damage potential of induced earthquakes is compared to that of natural tectonic events, considering recent instrumental data and felt records from events of M 3.5–5.8 (in which M is the moment magnitude). Ground motions are mutually consistent at close distances (<30  km) for natural earthquakes in California, induced earthquakes in Oklahoma, and induced earthquakes in western Canada, despite differences in the dominant processes that trigger the events. Recorded peak ground motions may exceed the damage threshold for induced events of M∼4.0 within ∼5  km of the hypocenter; events of M≥4.5 are inferred to have significant damage potential within 5 km and may be damaging to greater distances. Felt and damage effects in Oklahoma, as reported on the U.S. Geological Survey’s online “Did You Feel It?” system, show that the damage threshold (modified Mercalli intensity [MMI] = 6) is commonly exceeded for events of M∼4.5 at close distances (<10  km) and that significant damage effects (MMI=7) are observed for M>4.8 events within 10 km.
Empirical and Synthetic Approaches to the Calibration of the Local Magnitude Scale, ML, in Southern Kansas
Authors: Al-Ismail Fatimah , Ellsworth William L. , Beroza Gregory C.
Published: March 2020

We calibrate the local magnitude (ML) scale in southern Kansas, a region of increased seismicity due to oil and gas activities, using both an empirical and a synthetic approach to derive the attenuation curve. In the empirical approach, we use the classic Richter (1935)logA0 attenuation model to calculate ML using amplitude data from the southern Kansas Network catalog and calibrate it using moment magnitudes (Mw) from St. Louis University moment tensor solutions and Trugman et al. (2017). In the synthetic approach, we utilize a crustal velocity model to generate synthetic seismograms from which we measure amplitudes to estimate the attenuation curve. This second approach presents a novel way to calibrate ML, in any region of interest, when earthquake data are scarce or unavailable. Both approaches show lower attenuation in southern Kansas than in the relations being used by the U.S. Geological Survey and Oklahoma Geological Survey to compute ML values in this area. This difference results in a systematic decrease of ∼0.1 magnitude unit between our results and those reported in the southern Kansas Network catalog. We also find a dependence of ML on stress drop for earthquakes with corner frequencies near and below the Wood–Anderson instrumental corner of 1.25 Hz. The derived attenuation curve is consistent with a mean stress drop of 3–4 MPa for these earthquakes.
Effects of Initial Stress Field and Critical Slip-Weakening Distance on Rupture Selectivity of 3D Buried Branched Faults
Authors: Qian Feng , Zhang Haiming
Published: March 2020

Using the boundary integral equation method with the slip-weakening friction law, we investigate the effects of the initial stress field and the critical slip-weakening distance on the rupture selectivity on the 3D buried branched faults. The numerical results show that after reaching the bifurcation line between the main fault and the branched faults, rupture continues to propagate on one or both bifurcation planes (BPs), with rupture on one plane more favorable than the other. The initial stress distribution plays a decisive role in the selection of the favorable BP (FBP), and there is a critical status of stress distribution, around which rupture propagates on both planes, whereas the FBP switches between the two. For a given fault geometry, the critical status of initial stress, which is described by a ratio Fp between normal stresses, is related to the critical slip-weakening distance Dc.
Bitki Yaşı ve Hasat Zamanının Kuşkonmaz Verimi ve Sürgün Kalitesi Üzerine Etkileri
Authors: KÖKLÜ Şebnem , DOLUNBAY Sevda , YAKUPOĞLU Gökçen , KARACA Aygül , HAVAN Abdullah , KORKMAZ Ahmet
Published: March 2020

Bu çalışmanın amacı farklı hasada başlama yaşı (2 ve 3 yaş) ve hasat zamanlarının (bahar ve yaz aylarında) kuşkonmaz verimi ve sürgün kalitesi üzerine etkilerini araştırmaktır. Bu amaçla UC 157 F1 çeşidi kuşkonmaz fideleri 2011 ve 2012 yıllarında araziye dikilmişlerdir. Hasada bitkiler iki ve üç yaşlarına geldikleri 2014 yılında başlanmış ve kuşkonmaz bitkilerinin yarısı ilkbaharda diğer yarısı da yazın hasat edilmiştir. Hasada başlama yaşı sürgün verimi ve kalitesini önemli bir şekilde etkilemiş ve 2 yaşında hasada başlanan bitkilerden daha az sayıda sürgün hasat edilmiştir. Ayrıca hasat zamanı, sürgün verimi ve kalitesini etkilemiş ve baharda hasat edilen bitkilerden daha fazla sayıda ve daha kalın sürgün hasat edilmiştir. Baharda yapılan hasat sonucunda 8-12 mm kalınlığa sahip sürgün sayısı azalmış buna karşın 12-16 mm ve 16 mm’den kalın sürgün sayısında artış gözlenmiştir. Tüm bu sonuçlar kuşkonmaz bitkilerinin 2. yılda uzun dönem sürgün verim ve kalitesi üzerinde olumsuz bir etkiye sahip olmadan hasat edilebileceğini göstermiştir. Ayrıca, sürgünlerin sayısı ve kalitesi dikkate alındığında, yaz hasadının sadece ürün fiyatının yüksek olması kaydıyla bahar hasadına alternatif olabileceği görülmüştür.
Investigación en instrucción de vocabulario de preescolares en contextos de riesgo socioeconómico: una revisión de literatura
Authors: Pizarro Laborda Paulina , Espinoza Velasco Victoria , Riquelme Arredondo Angélica
Published: March 2020

This literature review analyzes 32 scientific articles about preschool vocabulary practices in contexts of socioeconomic vulnerability. In a search of the “Web of Science” database, and by “snowball”, three questions were asked: Does the initial level of vocabulary of the children have an impact on their vocabulary, when they receive vocabulary instruction? How has the lexicon been evaluated in preschoolers? And finally, has the effect of the frequency of the use of new words and its impact on the children vocabulary been explored? The results show that the level of initial vocabulary of the children would have an impact on their final level of vocabulary, as well as it has multiple facets of evaluation. Finally, the frequency of teaching a word occurs at least through a tale reading, in conjunction with some explicit vocabulary instruction practices.
Asociación entre las prácticas contemplativas, las habilidades sociales y los problemas de conducta de párvulos entre 24 y 61 meses de edad
Authors: Lería Dulčić Francisco José , Sasso Orellana Patricia Ester , Salgado Roa Jorge Alejandro
Published: March 2020

This article explores the association between contemplative practices and social skills of children between 24 and 61 months of age, throughout the implementation of an educational program for the development of socio-affective skills in early childhood education. 94 toddlers participated within a descriptive, associative and a longitudinal design which uses Merrell Preschool and Kindergarten Behavior Scale; Social Skills Scale for Parents/Caregivers of Lacunza; and a brief sociodemographic survey. Positive differences were found in the post-test for Social Interaction, Social Cooperation and Social Independence; and negative differences in Externalization and Interiorization of Behavior Problems. The findings are discussed as well as its possible contributions to early childhood education.
Outcomes of pleural decortication in a tertiary care hospital of Telangana state
Authors: Kummari Madhusudan , Malempati Amaresh Rao , Palanki Surya S. Gopal , Bomma Kaladhar , Goutham Chakravarthy
Published: March 2020

Background: The objective of the study was to study the clinical profile, incidence of postoperative complications in patients undergoing pleural decortication.Methods: The subjects for the study were selected from the cases admitted in a single unit of Department of Cardiothoracic Surgery, Nizam’s Institute of Medical Sciences, Hyderabad during the period of 2016 to 2018 and due ethics committee approval was taken.  Collection of data is done from the database including admission record, ICU charts, discharge records and follow-up records. 50 patients underwent surgery. Outcomes and complications were analyzed for 3 years duration.Results: 50 patients were included in this study with different aetiologies that required pleural decortication. The average age of patients in our study was 34 years. Most patients in our study were male (80%) and had history of infection with tuberculosis (42%) and pyogenic (28%) infection. A few patients had history of trauma (12%). Most of the patients suffered from cough (88%), dyspnoea (74%), fever (82%) and haemoptysis (22%). The common postoperative complications we encountered were pleural air leak (37.5%) bleeding (25%) infection (25%) and recurrence (2%). Overall morbidity from pleural decortication was seen in 16 patients, and there was no mortality.Conclusions: The most common reason for pleural decortication is still empyema thoracis secondary to infection in the developing countries. Tuberculosis is still the most common cause leading to fibrothorax requiring pleural decortication followed closely by pyogenic lung infections and trauma.
Outcomes following transaortic septal myectomy in hypertrophic cardiomyopathy
Authors: Kummari Madhusudan , Malempati Amaresh Rao , Gopal Palanki Surya S. , Bomma Kaladhar
Published: March 2020

Background: The objective of the study was to evaluate effect of myectomy and its impact on survival for a period of one year and to identify the co-morbid conditions that would increase the risk of surgery.Methods: The study was conducted on the patients admitted in a single unit of department of cardiothoracic surgery, NIMS, Hyderabad during the period of 2014 to 2018. The study was a retrospective observational study. 21 patients were enrolled in the study after approval from institute ethics committee. All the patients between 7 to 70 years who underwent septal myectomy were included in the study.Results: Out of the 21 patients underwent modified Morrows myectomy 16 (76.2%) were male and 5 (23.8%) were female. The most common presenting symptom was dyspnea (81%), followed chest pain (76%), palpitations (62%) and syncope (38%). 5 (24%) patients had a family history of sudden cardiac death. Preoperative beta blockers were used by 15 (72%) patients. 11 patients had severe mitral regurgitation, out of which 8 patients underwent valve replacement and 3 underwent mitral valve repair. The mean preoperative left ventricular outflow tract obstruction gradient was 86.86 and the mean postoperative gradient was 23.47. 3 patients had implantable cardioverter defibrillator insertions. All patients had symptom relief.Conclusions: Surgical treatment of hypertrophic cardiomyopathy through transaortic septal myectomy is safe and effective method to relieve left ventricular outflow tract obstruction. Mitral valve replacement can be done for cases with structural defect of mitral valve. Early detection and intervention in patients with family history of sudden cardiac death would reduce the risk of death and ensure long term survival.
A Study on Reuse-based Requirements Engineering by Utilizing Knowledge Pattern
Authors: Ahmad Sabrina , Hashim Zariza , Asmai Siti Azirah
Published: March 2020

Software development has become an essential part of many industries over the past decade. The use of software has become an essential element for the organization to support its operation and business. Some software has certain features in common, which allow its requirements to be used repetitively in the requirement engineering phase. This paper presents a study on knowledge patterns for reuse-based requirements engineering. Reuse-based requirements engineering is saving the effort to conduct the process and, at the same time maintaining the standard since reused requirements come with its properties as well.  Software development is an iterative process itself and so does the knowledge it holds in every iteration. When analysts perform many iterations of elicitation processes, it is often the case that a significant amount of requirements is recurring and similar software system will likely benefit from them. This research adopted a literature review method to investigate and to present current studies on knowledge pattern for the purpose of reuse. Knowledge reuse by utilizing knowledge pattern is becoming a significant method in software requirements engineering as it safes the effort of developing requirements from scratch. The study found that a specific pattern is required to develop good requirements specification. A proposed prototype to deploy reuse-based requirements engineering is also presented and evaluated. Experts’ judgment method is used for evaluation by adapting the Technology Acceptance Model (TAM). The results showed that reusing knowledge pattern expedites the requirements elicitation process and improves the requirements quality.
A Comparative Study of Segmentation Algorithms in the Classification of Human Skin Burn Depth
Authors: Kuan P.N. , Chua S. , Safawi E.B. , Wang H.H.
Published: March 2020

A correct first assessment of a skin burn depth is essential as it determines a correct first burn treatment provided to the patients. The objective of this paper is to conduct a comparative study of the different segmentation algorithms for the classification of different burn depths. Eight different hybrid segmentation algorithms were studied on a skin burn dataset comprising skin burn images categorized into three burn classes by medical experts; superficial partial thickness burn (SPTB), deep partial thickness burn (DPTB) and full thickness burn (FTB). Different sequences of the algorithm were experimented as each algorithm was able to segment differently, leading to different segmentation in the final output. The performance of the segmentation algorithms was evaluated by calculating the number of correctly segmented images for each burn depth. The empirical results showed that the segmentation algorithm that was able to segment most of the burn depths had achieved 40.24%, 60.42% and 6.25% of correctly segmented image for SPTB, DPTB and FTB respectively. Most of the segmentation algorithms could not segment well for FTB images because of the different nature of the burn wounds as some of the FTB images contained dark brown and black colors. It can be concluded that a good segmentation algorithm is required to ensure that the representative features of each burn depth can be extracted to contribute to higher accuracy of classification of skin burn depth.