bluuebunny/crossref_metadata_2025 huggingface dataset:
In vivo acute and subacute toxicity assessments of Viroscope®, a polyherbal ethanolic formulation produced in Lomé, Togo
Authors: Dossouvi Komla , Dossouvi Kossi , Dossouvi Akueba , Dossouvi Kokou
Published: June 2024

Background: Phyto-medicines have been used to treat various diseases since ancient times. However, several studies have reported the toxicity of some medicinal plant preparations. Objective: This study aimed to evaluate the in vivo acute and subacute toxicity of an ethanolic extract of medicinal plants, “VIROSCOPE®”, produced by Viroscope SARL-U in Lomé, Togo. Materials and Methods: Acute toxicity assessment was conducted according to the “OECD guideline 423 for the assessment of the acute toxicity of chemicals.” This study focused on the ready-to-use VIROSCOPE® and on the concentrated extract obtained after evaporation. Subacute toxicity was assessed according to the “OECD guideline 407 for the study of subacute toxicity of chemicals.” Control rats; VIROSCOPE®; solvents; 100, 500, and 1000 mg/kg of the dry extract of VIROSCOPE® dissolved in drinking water were tested.The mortality rate, toxicity symptoms, food and water consumption, and changes in body weight were monitored. Biochemical and haematological parameters were also measured. Furthermore, histopathological analysis of hepatic and renal cells was conducted. Results : The median lethal dose (LD50) was > 5000 mg/kg. Repeated doses of the trial drug over a long period of 28 days had no major risk. In addition, it did not induce any pathological variations in biochemical and haematological parameters. According to histopathological results, there was no significant harmful effect to liver and kidney cells. Conclusion: VIROSCOPE® can be considered safe and must be administered strictly according to the indicated dosages on its bottle.
Significance of Yogic Lifestyle in controlling Obesity
Authors: PATEL VINOD , Patidar Mrityunjay , Kesar Kesar , Nathani Neeru
Published: June 2024

Background: Obesity is supposed to be a gift of sedentary lifestyle. In obesity there is an excessive increase in body weight because of extra fat accumulation. The common symptoms in obesity are weight gain, heaviness in the body, general lassitude, breathlessness on exertion, excessive sleep etc. It may arise due to lack of exercise and faulty lifestyle (improper Ahara-Vihara), stress, imbalance of thyroid hormones and pituitary hormones. Yoga establishes harmony between body, mind and emotions. Obesity can be controlled through yoga-based lifestyle including healthy diet, healthy daily routine, proper efforts in action, proper sleep-awakening and regular observance of yogic practices viz. Shatkarma (cleansing processes), Asana (yogic postures), Pranayama (breathing practices), Mudra (yogic gestures), Bandha (yogic locks) and Dhyana (meditation).
Aim: To review and analyse the importance of yogic lifestyle in controlling Obesity.
Material and Methods: An extensive review of ancient yogic literature, research journals and reports was done. Review of classical textual data was gathered from texts of hatha yoga and contemporary sciences with scholarly articles related to yoga and obesity.
Results: This review suggests the practice of Shatkarmas, Asana, Pranayama, Bandha, Mudra and Dhyana could be beneficial in obesity. The Shatkarmas help in purification of body & regular practice of Asana are useful to relax body, strengthen muscles, remove excessive fat of the body. Pranayama brings energy to the body and purifies Nadis (energy channels). Meditation helps in relieving stress and balancing the mind.
Conclusion: Obesity is one of the major risk factors for many metabolic disorders like type 2 diabetes, hypertension, hyperlipidaemia etc. Various researches proved that specific Yogic practices are beneficial in controlling obesity. Adoption of Yogic lifestyle could be a cost-effective solution to the society for prevention and control of obesity.
Clinical and epidemiological profile of herpes zoster cases and its complications: A prospective study
Authors: Budihal Ashwin , Gudikote Madhuri , P Naveen , R Vidya
Published: June 2024

Background: The varicella-zoster virus, which is known to lie dormant in the dorsal root ganglia after primary chickenpox infection or immunization, and in rare instances, intrauterine infection, is the source of the common viral infection known as herpes zoster (HZ). In healthy people, the illness usually goes away on its own, but in severely immunocompromised patients, it can cause persistent debilitation through multi-dermatomal, severe, vesiculo-pustular, nodular, crusted, and ecthymatous manifestations.

Aims and Objectives: The aim of this study was to better understand the clinical profile and epidemiological patterns of HZ and various postherpetic complications.

Materials and Methods: A prospective cross-sectional study was conducted at a tertiary care hospital in Karnataka for 24 months during August 2013–August 2015. Seventy-five patients with HZ and postherpetic complications attending the dermatology outpatient department were included in the study. Pre-existing comorbidities and patient details were recorded. The Hayes and Patterson Visual Analog Scale (VAS) was used to record the kind, duration, and intensity of the pain.

Results: The current cross-sectional study was done in a tertiary care hospital, and a total of 75 patients were considered for the study. The youngest patient was a 12-year-old male and the eldest patient was a 90-year-old male. The average age of patients was 52.45 ± 12.5 years. Cutaneous examination showed erythema (84%) and vesicles (84%). The intensity of pain was classified based on the VAS. About 54.6% of patients had a moderate degree of pain.

Conclusion: Acute vesicles with erythema and radicular pain with a unilateral dermatomal distribution are the most typical presentation of HZ infection, and they are most frequently seen in the thoracic area.
Effect of cigarette smoking on lipid profile, high sensitivity c-reactive protein, and malondialdehyde
Authors: P Fathima , KP Kalyanikutty
Published: June 2024

Background: One of the most common reasons for preventable mortality is the smoking habit. Cigarette smoke promotes the process of atherogenesis by producing oxygen-derived free radicals which cause damage to the lipids. Cigarette smoking is associated with impaired endothelium-dependent vasodilatation and cardiovascular disease (CVD).

Aims and Objectives: The objectives of the study were the following: (i) to compare the levels of total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), and very LDL (VLDL) in asymptomatic male smokers and non-smokers of the age group 25–50 years; (ii) to determine and compare the levels of high sensitivity C-reactive protein (hs-CRP) in the above two groups, and (iii) to study and compare the levels of malondialdehyde (MDA) in the above groups.

Materials and Methods: The study was conducted on 60 males in which 30 smokers and 30 non-smokers of the age group 25–50 years were incorporated. It was a cross-sectional comparative study, which included the participants who met all the inclusion and exclusion criteria. Before the conduct of the study, informed consent was obtained from all the participants. Moreover, the selection of participants was done in a consecutive manner until the sample size was achieved. TC and TGs were estimated by the enzymatic colorimetric method, HDL cholesterol by the phosphotungstic acid method, and LDL and VLDL by Friedwald’s formula. MDA was determined by spectrophotometry and hs-CRP by the immunoturbidometric method. The data acquired were analyzed by utilizing the Statistical Package for the Social Sciences version 18.

Results: Dyslipidemia was seen in smokers as evidenced by significantly elevated levels of TC, TG, LDL, and VLDL; and significantly reduced levels of HDL. The mean values of hs-CRP were significantly elevated in smokers when compared to that of non-smokers. Oxidative stress was increased in subjects who were smokers. The mean values of MDA were significantly elevated in the smokers.

Conclusion: The smoking habit is associated with dyslipidemia, oxidative stress, and inflammation which predisposes to the development of endothelial dysfunction and atherosclerosis. The significance of early screening measures to be undertaken in asymptomatic smokers for dyslipidemia, oxidative stress, and hs-CRP is unveiled by the present study. Therefore, early screening can be used to advise smokers to refrain from smoking to avoid complications of CVDs, so that they can upgrade the quality of their life.
Clinical presentation and diagnosis of pediatric urinary tract infections: A comprehensive study
Authors: K Favas , K Muhammed , K Noushadali , Jose Santhosh
Published: June 2024

Background: Urinary tract infections (UTIs) pose a significant health concern for children worldwide, with a prevalence ranging from 2% to 20%. If not promptly diagnosed and treated, these infections can lead to severe complications such as renal scarring, hypertension, and chronic renal failure.

Aims and Objectives: This study aims to evaluate the clinical presentation, diagnostic methods, and common bacterial pathogens associated with pediatric UTIs. The focus is on identifying age-specific symptoms and improving diagnostic accuracy to mitigate long-term complications.

Materials and Methods: Over 1 year, we conducted a cross-sectional study at MES Medical College in Perinthalmanna, Kerala. Fifty-four children with culture-positive UTIs were included. Clinical data were collected using a semi-structured pro forma, and laboratory tests were performed to identify the causative organisms and their antibiotic susceptibility patterns.

Results: Among neonates, fever (100%), jaundice (100%), and vomiting (83.3%) were the most common symptoms. Older children predominantly presented with fever (93.3%), pain or burning during urination (79.63%), and lethargy (53.7%). Escherichia coli was the most frequently identified pathogen, followed by Klebsiella pneumoniae and Pseudomonas aeruginosa. High sensitivity was noted for piperacillin-tazobactam (100%) and amikacin (88.89%).

Conclusion: Early and precise diagnosis of pediatric UTIs, based on specific clinical presentations and laboratory tests, is crucial for preventing severe complications. Recognizing common pathogens and their antibiotic sensitivities helps in developing effective treatment guidelines.
Palaeoecological significance of the trace fossil Circulichnis Vyalov, 1971 from the Carboniferous of the Donets Basin, Ukraine
Authors: DERNOV Vitaly
Published: June 2024

The ichnogenus Circulichnis Vyalov is a horizontal a ring- or ellipse-shaped burrow and/or locomotion trace of an unknown producer, most likely an annelid or a “worm”, preserved on the bedding plane. This ichnogenus is known over a wide age interval (Ediacaran–Oligocene). Circulichnis demonstrates a wide ecological range and has been found in continental (Mermia ichnofacies), shelf, and relatively deep-water (turbidites) deposits. It is commonly interpreted as a sediment feeding trace, but the peculiarities of its formation remain somewhat mysterious, as it is unclear how the tracemaker reached the sediment surface, as lateral branches of the ring-shaped traces are extremely rare and have only been observed by a few researchers. A rather large specimen of Circulichnis montanus Vyalov, 1971 with a preserved lateral branch was found in the Mospyne Formation (upper Bashkirian, Lower Pennsylvanian) of the Donets Basin. This discovery confirmed the assumption made by Alfred Uchman and Bruno Ratazzi regarding the peculiarities of formation of Circulichnis. According to these authors, a single ring-shaped Circulichnis indicates an attempt to forage at a specific level in the sediment, while the lateral branches of Circulichnis are part of a vertical shaft leading to another level within the sediment. The study of Circulichnis montanus from the Donets Basin has confirmed that at least variant C of the Circulichnis formation scheme proposed by Uchman and Ratazzi is correct, i.e. the lateral branch is a horizontal or subhorizontal part of a generally vertical shaft. However, it is important to note that the correctness of variants A and B of the Uchman and Ratazzi scheme cannot be excluded. To answer this question unequivocally, new finds of well-preserved Circulichnis are necessary.
ESPIRITUALIDADE É SAÚDE!: NÃO SE CURA O CORPO ANTES DE CURAR A ALMA
Authors: Marques Glauco Alexandre de Melo
Published: June 2024

Como historiador e professor, tendo como base a filosofia, a política e a racionalidade, que sempre fez parte de minha formação intelectual e moral, vindo de uma família de professores até profissionais liberais. Minha família é eclética, até sua intercessão: a religião. Na contradição entre razão, por isso meu nome é Glauco, discípulo de Platão e a fé. O kardecismo é a égide da família de minha mãe. No qual, por ser filho mais velho, era obrigado a lhe acompanhar, o que estudava e a doutrina praticava, não me criava interrogações intelectuais e morais, mas existenciais. Com a che- gada da pandemia e fazendo uma aula do curso de medicina de: “espiritualidade e saúde”, coube a mim uma apresentação gravada no youtube, onde trago perguntas e indagações.. No vídeo que está nas referências bibliográficas, discorro sobre a importância da espiritualidade, e faço a provocação e cerne de minha pesquisa: espiritualidade “é” saúde!? Não correlacionando uma com a outra, mas buscando provar que uma é imprescindível para chegar à outra. Nosso artigo será pautado na ideia de uma Genealogia da Vida (perspectiva Nietzschiana), sobretudo no que diz respeito no poder da espiritualidade, como parte integrante , principalmente na Ciência , afinal , nós , seres humanos , se- gundo a perspectiva da Grécia Antiga, somos formados pelo nosso corpo, que é constituído por nos- sa mente e nosso sangue, e também, pela nossa alma , pois é através dela , que nós damos nosso pri- meiro suspiro e nosso último. A anima (alma) em Grego é chamada de Psyché. E de Emmanuel Kant, que expõe que o intelecto humano pode e deve ser medido pela sua capacidade de colecionar incertezas, as religiões via teologia acabaram nos abastecendo de proteínas de certezas, e nosso inte- lecto ficou preso, nos impedindo de compreender que espirito e corpo são indivisíveis. "A cura é sempre comprometida com um ponto de vista moral ". Se pararmos para pensar, esse tipo de raciocí- nio pode ser visto diariamente, quando uma pessoa é curada de uma enfermidade e ela , ao receber o diagnóstico da cura, agradece primeiramente a Deus.
OS DESAFIOS DOS PROFESSORES DIANTE DAS TECNOLOGIAS NO CONTEXTO ESCOLAR
Authors: Teles Leila Vilela de Almeida , Souza Jane Alves de , Faria Glaudes Braz , Barbosa Suely Pereira , Goulart Ceila Maria Barbosa , Barbosa Junior Nilson do Carmo , Lopes Edite da Costa Barbosa , Silva Skarlatty Santa Alves da , Andrade Maria Auxiliadora Arbués de , Moraes Fabiana Cristina Roseno de
Published: June 2024

A Educação na atualidade tem utilizado as ferramentas e instrumentos tecnológicos necessários no processo de aprendizagem dos alunos e um meio que auxilia a prática docente, tornando assim, as aulas mais participativas, prazerosas, dinâmicas e que estimulam mais ainda os alunos para melhor utilizar destas ferramentas, visando assim, o seu processo de ensino e aprendizagem e favorecendo sua autonomia intelectual. Diante disso, o artigo tem o objetivo de discutir sobre os principais desafios encontrados pelos professores diante das tecnologias no contexto escolar. E o problema resumiu-se neste questionamento: Quais os principais desafios encontrados pelos professores diante das tecnologias no contexto escolar? Sabe-se que os professores têm grandes dificuldades diante das tecnologias em sua prática pedagógicas, dificuldades essas como a restrição de usar esta ferramenta, a falta de capacitação também desafio frequente dos professores, pois muitos não sabem utilizar este instrumento como forma de facilitar a sua pratica pedagógica e contribuir na aprendizagem dos alunos. Para a compreensão desta temática será utilizada uma pesquisa bibliográfica como forma de ampliação e discussão do mesmo.
Optimalisasi Peran Negara dalam Menangani Kelompok Kriminal Beresnjata (KKB) Papua Ditinjau dalam Perspektif Undang-Undang Nomor 5 Tahun 2018 dan Undang-Undang yang Berkaitan dengan Ham di Indonesia.
Authors: Rio Ananda Andriana  , Pramesti Ratu Fiqih  , LM. Alif Pratama
Published: June 2024

Peran negara sangat dibutuhkan ketika terjadi konflik separatisme yang dapat meruntuhkan NKRI. Salah satu contohnya adalah seperti yang sedang terjadi di Papua, di mana Kelompok Kriminal Bersenjata di sana terus mengintervensi untuk memerdekakan kelompok mereka dari negara Indonesia, konflik yang disebabkan oleh KKB ini terus mengguncang Papua, banyak korban yang telah berjatuhan dari pihak sipil maupun aparat penegak hukum. Dengan melihat permasalahan tersebut, maka penting untuk segera menyelesaikan permasalahan ini dibarengi dengan kehati-hatian, karena permasalahan KKB di Papua ini sangat sensitif. Penelitian ini dilakukan secara yuridis normatif dengan cara penelitian hukum melalui kepustakaan yang dilakukan dengan meneliti bahan-bahan kepustakaan dari penelitian terdahulu, serta permasalahan dalam penelitian ini adalah masih eksisnya KKB di Papua, yang mana setiap kebijakan hukum sangat penting untuk selalu dilibatkan dan diperhatikan dalam penanganan kasus KKB di Papua, karena kebijakan hukum adalah hal mendasar untuk melakukan langkah penyelesaian-penyelesain berikutnya. Pada dasarnya berbagai aturan hukum di Indonesia sudah secara tidak langsung dapat memberikan ruang dalam penanganan KKB. Dalam hal ini juga  pemerintah pusat dan pemerintah daerah harus selalu bersinergi untuk memberikan andil dalam mengoptimalkan kebijakan hukum yang telah dibuat agar peran negara ada untuk masyarakatnya, sehingga negara yang sejahtera akan bisa terwujud.
Kata Kunci: Peran negara, Kebijakan Hukum, Kelompok Kriminal Bersenjata, Papua.
HUBUNGAN NLR DENGAN KADAR HS-CRP PADA KASUS DEMAM DENGUEPERIODE TAHUN 2019-2021 DI PRODIA DEPOK
Authors: Ekawati Dhian , Wijayanti Dian Rachma , Ritonga Ahmad Fitra Ritonga
Published: June 2024

Demam dengue (DD) merupakan penyakit yang disebabkan oleh virus dengue dan ditularkan melalui vektor nyamuk Aedes aegypti dan Aedes Albopictus. Gejala klinis yang ditimbulkan berupa demam 2–7 hari, sakit atau nyeri pada ulu hati serta manifestasi perdarahan. Pada infeksi yang lebih berat disertai dengan leukopenia dan trombositopenia. Neutrophil Lymphocyte Ratio (NLR) dan High sensitive C-reactive protein(Hs-CRP) menjadi salah satu pemeriksaan penunjang DD. Rasio neutrofil limfosit atau NLR memberikan gambaran terhadap respon imun dan derajat inflamasi yang terjadi Hs-CRP merupakan protein fase akut yang diproduksi oleh hati sebagai respon imun nonspesifik terhadap infeksi. Penelitian ini bertujuan untuk mengetahui hubungan NLR dengan kadar Hs-CRP pada kasus DD tahun 2019-2021 di Prodia Depok, sebanyak 30 pasien dengan diagnosis DD menjadi subjek dalam penelitian ini. Penelitian dilakukan dengan desain penelitian cross-sectional. Hasil yang diperoleh dari penelitian ini adalah 16 responden laki-laki dan 14 responden. Usia yang mendominasi adalah kategori lansia awal dan akhir (46-65 tahun) sebanyak 10 responden. Berdasarkan Uji Spearman p-value 0,989 yaitu tidak ada hubungan antara nilai NLR dengan kadar Hs-CRP pada kasus DD Prodia Depok.
Faktor Predisposing Sexual Harassment Tenaga Kerja Wanita Di Bidang Industri
Authors: Mella Mella Yuria , Gustina Irwanti
Published: June 2024

Sexual harassment (pelecehan seksual) merupakan fenomena yang terjadi di dunia kerja negara maju ataupun negara berkembang dan meningkat setiap tahunnya. Pelecehan seksual di Asia Pasifik mencapai 30% - 40% dari masalah ketenagakerjaan. Penelitian ini bertujuan untuk menganalisa faktor predisposisi sexual harassment pada tenaga kerja wanita di bidang industri. Desain penelitian yaitu Cross sectional. Populasi pada penelitian adalah tenaga kerja wanita di dua pabrik wilayah Bekasi yang berjumlah 477 orang. Sampel penelitian menggunakan teknik purposive sampling sebanyak 50 responden. Hasil menunjukan 14% tenaga kerja wanita mengalami sexual harassment, 10 % memiliki pendidikan akhir SMA sederajat, 14 % memiliki pengetahuan yang baik tentang pelecehan seksual, 8 % telah bekerja selama 1-2 tahun dan 10 % pekerja wanita memiliki penghasilan di bawah UMR. Analisa Chi Square diperoleh p value (0,007) untuk tingkat pendidikan, pengetahuan dan penghasilan serta (0,006) untuk masa kerja. Tingginya kejadian Sexual harassment diperlukan sosialisasi penegakan hukum terhadap pelaku pelecehan seksual pada pekerja wanita.
Pengaruh Skin-To-Skin Contact Terhadap Penurunan Suhu Tubuh Bayi Pasca Imunisasi Pentabio
Authors: Rahmawati Emilia , Keswara Nila Widya , Wijayanti Tut Rayani Aksohini
Published: June 2024

Demam terjadi ketika suhu tubuh meningkat lebih dari 37,5⁰C di atas normal akibat peningkatan pusat pengatur suhu hipotalamus. Suntikan imunisasi Pentabio akan menyebabkan peningkatan suhu tubuh singkat pada bayi, hal ini akan diikuti dengan penurunan suhu tubuh satu hingga tiga hari kemudian. Tujuan dari penelitian ini adalah untuk mengetahui apakah dengan menggunakan metode kontak kulit ke kulit di PMB Eny Islamiati Bululawang dapat menurunkan suhu tubuh bayi setelah pemberian vaksin Pentabio. Jenis penelitian yang digunakan secara kuantitatif dengan menggunakan desain quasi experimental  dengan jenis rancangan post test only non equivalent grup design. Sampel dalam penelitian ini adalah bayi yang mendapatkan imunisasi Pentabio sebanyak 32 bayi dengan menggunakan metode purposive sampling. Termometer digital dan lembar observasi adalah alat yang digunakan. Para peneliti menggunakan rasio p-value sebesar a = 0,05 untuk analisis univariat dan bivariat. Sebagai konsekuensi dari temuan penelitian, yang menunjukkan bahwa pendekatan kontak kulit ke kulit memiliki efek dalam menurunkan suhu tubuh bayi, dapat disimpulkan bahwa nilai p-value adalah 0,000 < 0,05 dan H1 dapat diterima. Rekomendasi untuk meningkatkan kesadaran masyarakat, khususnya mengenai teknik kontak kulit ke kulit, yang dapat membantu menurunkan suhu tubuh bayi setelah vaksinasi Pentabio.
Hubungan Pengetahuan dan Persepsi dengan Sikap Mahasiswa tentang Alat Kontrasepsi IUD
Authors: Wardani Suci Fitriana Pramudya , Ismiyati Inayah
Published: June 2024

kontrasepsi IUD. Seiring menurunnya pengetahuan perempuan, maka penggunaan alat kontrasepsi, khususnya IUD, juga akan menurun. Terdapat mitos yang menyatakan bahwa IUD dapat mempengaruhi kenyamanan hubungan seksual, kesalahpahaman dan pandangan subjektif dapat menyebabkan sebagian orang masih awam dalam menggunakan IUD sebagai alat kontrasepsi. Apabila wanita dibekali pengetahuan tentang alat kontrasepsi IUD maka kesadaran untuk menggunakannya akan lebih tinggi, sehingga rendahnya minat ibu akan lebih kecil. Penelitian ini dilakukan dengan memiliki tujuan untuk mengetahui Hubungan Pengetahuan dan Persepsi Dengan Sikap Mahasiswa Sekolah Tinggi Ilmu Kesehatan Brebes Tentang Alat Kontrasepsi IUD Tahun 2023. Jenis yang digunakan dalam penelitian ini adalah survey analitik dengan jumlah sampel penelitian 48 sampel yang dilakukan di STIKes Brebes. Instrumen Penelitian yang digunakan pada penelitian ini adalah kuesioner dengan daftar pertanyaan tentang pengetahuan,sikap,dan persepsi Kontrasepsi IUD yang diberikan responden. kemudian pengolahan data menggunakan data analisis uji statistik chi-square. Hasil uji statistik antara pengetahuan dengan sikap responden, didapatkan hasil p<0,05, hasil uji statistic antara persepsi dengan sikap responden diperoleh hasil p>0,05). Terdapat hubungan antara sikap dengan pengetahuan IUD di STIKES Brebes tahun 2023 dan Tidak ada hubungan antara sikap dengan persepsi IUD di STIKES Brebes tahun 2023. peran tenaga kesehatan dalam memberikan informasi sangat diperlukan guna untuk meningkatkan pengetahuan tentang alat kontrasepsi IUD.
Opportunities and trends of transcutaneous auricular vagus nerve stimulation
Authors: Xin Chen , Zhang Yuzhengheng , Guo Jing , Wang Yu , Wang Yifei , Zhao Yanan , Zou Ningyi , Li Shaoyuan , Rong Peijing
Published: June 2024

Background: After more than two decades of development, transcutaneous auricular vagus nerve stimulation (taVNS) has surpassed its role as a mere alternative to VNS and is now applied to various disorders. This study presents a bibliometric analysis to evaluate the global scientific output of taVNS research, aiming to describe its current status and identify potential future trends.
Methods: We conducted a systematic retrieval of taVNS-related studies published between 2000 and 2022 from the Web of Science database. VOSviewer was used to construct networks based on country/institution/author co-authorship, journal/reference co-citation analysis, literature citation analysis and keyword co-occurrence.
Results: A total of 523 relevant articles and reviews were included. Since 2012, there has been a rapid increase in publications and citations. China emerged as the leading contributor in terms of publication output, while Germany had the highest number of citations. Interestingly, research groups from different countries exhibited distinct research ideas and characteristics concerning taVNS, yet collaboration between these groups remained limited. Through a focused examination of key aspects in this field, we identified significant opportunities for the future advancement of taVNS.
Conclusion: This bibliometric analysis emphasizes the interest in and recognition of taVNS as a therapeutic intervention and identifies broader clinical applications, more precise stimulation, and the development and commercialization of wearable devices as key opportunities and challenges for the future.
Pengaruh Kurs dan Harga Minyak Dunia Terhadap Indeks Harga Saham Gabungan di Bursa Efek Indonesia
Authors: Budi Santoso Cahyo , Istiningrum Rr.Farida
Published: June 2024

Penelitian ini bertujuan untuk melihat pengaruh kurs dan harga minyak dunia terhadap Indeks Harga Saham Gabungan (IHSG). Objek dari penelitian ini adalah Indeks Harga Saham Gabungan (IHSG). Subjek penelitian ini adalah Bursa Efek Indonesia. Desain penelitian ini adalah penelitian asosiatif kausalitas dan merupakan penelitian time series. Data yang digunakan adalah data sekunder. Metode analisis data yang digunakan adalah regresi berganda dengan level of significant sebesar 0,05. Variabel dalam penelitian ini adalah Indeks Harga Saham Gabungan (IHSG), Kurs, dan Harga Minyak Dunia.
Berdasarkan hasil analisis data, Kurs berpengaruh negatif dan signifikan terhadap IHSG dibuktikan dengan nilai koefisien regresi Kurs sebesar 0,0816 dengan nilai siginifikansi sebesar 0,042. Harga Minyak Dunia tidak berpengaruh terhadap IHSG dibuktikan dengan nilai koefisien regresi Harga Minyak Dunia sebesar 0.278 pada signifikansi sebesar 0,073. Hasil koefisien determinasi sebesar 25,4%. Hal ini menunjukkan bahwa 25,4% variasi variabel dependen IHSG dapat dijelaskan oleh variabel independen Kurs, dan Harga Minyak Dunia sedangkan sisanya sebesar 74,6% dijelaskan oleh faktor-faktor lain yang tidak disebutkan dalam penelitian ini.
 
Kata Kunci : IHSG, Inflasi, Kurs, dan Harga Minyak Dunia
A STUDY ON HUMAN RESOURCE PLANNING AT RANE BRAKE LINING LIMITED, PUDUCHERRY
Authors:   Manakula Vinayagar Institute Of Technology  Puducherry-605107.
Published: June 2024

The research is under the theme “A STUDY ON HUMAN RESOURCE PLANNING” and the survey is carried out in the company called RANE BRAKE LINING LIMITED, SANYASIKUPPAM VILLAGE, PUDUCHERRY, 605107. The sampling procedure is simple random sampling. The research adopted a descriptive research design. Since the organization needs to improve, it is also recommended to improve interpersonal relations between employees. KEY WORDS Human Resource Planning, Survey, Descriptive Research design, Interpersonal Relations, Sampling Procedures, Organizational Development, Employee Relations.
Isabel Bogdan’ın “Laufen” Adlı Romanında Yürüyen Anlatı Ve Anlatılan Yürüme Bağlamında Kendini Bulma Yolculuğu
Authors: Uysal Dudu
Published: June 2024

İnsan ayağa kalkıp yürümeye başladığı günden beri, yürümek onun bedensel ve ruhsal gelişimi, değişimi ve dönüşümüne olanak sağlayan bir aktivite olarak görülür. Çalışma kapsamında öncelikle yürümenin yazarın eserini yaratma sürecine sağladığı katkılara değinilir. Yürüyen anlatının ve anlatılan yürümenin ne olduğu açıklanır. Bu ifadelerin ayırıcı özellikleri tüm ayrıntılarıyla ele alınır. Bu bağlamda çalışmanın konusu Isabel Bogdan’ın “Laufen” adlı romanıdır. Sevgilisinin intiharından dolayı üzgün olan ve bir yıl boyunca kendisini eve kapatıp yas tutan ana karakter hem dış hem de iç dünyasından sağlıksız bir şekilde geri çekilir. Başka bir ifadeyle kendini kaybeder. Kendini yeniden bulmak için her geçen gün daha uzun mesafeyi düzenli olarak yavaş yavaş yürümeye başlar. Bunun öncesinde üzgün figür olarak incelenen ana karakter kendisini yeniden bulmak için alternatif yollar arar ama bunlardan herhangi bir yarar sağlayamaz. Ana karakter yürüyen bir anlatı olarak, metin ise anlatılan yürüme olarak ele alınır. Ana karakterin kendini bulma yolculuğu bu şekilde başlar ve devam eder.
A review on plant with anti-inflammatory therapeutic activity
Authors: Patel Pradeep Kumar
Published: June 2024

Several synthetic anti-inflammatory drugs are available in the market. Out of them, few have promising activity and most of them have quite more undesirable effects. Herbal sources are most often used from ancient times to solve the root causes of numerous diseases & also they have potent as well as potential results with quite less adverse effects. Various extracts of plants (i.e. leaves, stem, root, bark, rhizome, etc.) have been found to possess anti-inflammatory activity due to the presence of several known & unknown phyto constituents. As we know inflammation is a common protective response but if it occurs beyond the limit in our body then it may be harmful. Investigation of plant sources for diseases is always beneficial for counteracting the undesirable effect that is happening in the case of synthetic drugs. In this article, we are trying to find some important plants which have potent anti-inflammatory active moiety.
Probiotics and human health
Authors: Gupta Amit
Published: June 2024

There are two types of bacteria in and on the human body that make up the micro biome: beneficial bacteria and harmful bacteria. Probiotics are helpful bacteria that promote health and fight off bad bacteria. A reduced level of disease-causing microorganisms in the body is one of probiotics' effects. The healthy colony of bacteria that takes place in the gut is the most frequent home for helpful microbes. Probiotic microbes may also be found in our lungs, skin, urinary system, mouth, and vagina. The balance between healthy and harmful microorganisms in our body must be maintained by probiotics. Probiotics have a wide range of positive effects, such as the prevention of cancer, the lowering of blood cholesterol, the absorption from the intestine, the boosting of the immune system, the prevention and treatment of diarrhoea, the reduction of gastrointestinal inflammation, and the relief of colitis and IBS (irritable bowel syndrome) symptoms. Probiotics help in digestion, nutrition absorption, the formation of biofilms, and the production of vitamins, particularly those in groups B and K. They also cure fungal and viral illnesses like athlete's foot. Probiotics can occasionally have negative effects on youngsters and immune compromised people.
Matrix tablets: benefits, drawbacks and hopes for the future
Authors: Yadav Vimal Kumar
Published: June 2024

The adaptability of matrix tablets, a common drug delivery technology, in regulated and sustained release has drawn a lot of attention in pharmaceutical research and development. The different facets of matrix tablets are examined in this abstract, along with their formulations, benefits, drawbacks, and potential applications. We talked about matrix tablet formulations, benefits, drawbacks, and potential future developments in this review study.
Diet and nutrient requirements in pregnancy
Authors: Tiwari Varsha
Published: June 2024

High food quality, together with adequate macroand micronutrient intake in pregnancy, is crucial for the health status of the mother and child. Recent findings suggest that it could also be beneficial or harmful in the context of the wellbeing of the whole future population. According to the developmental origins of health and disease hypothesis, most conditions that occur in adulthood originate in foetal life. Moreover, some epigenetic events, modified inter alia by diet, impact more than one generation. Still, the recommendations in most countries are neither popularised nor very detailed. While it seems to be important to direct diet trends towards a healthier lifestyle, the methods of preventing specific disorders like diabetes or asthma are not yet established and require further investigation.
Diuresis's importance in maintaining health and managing illness
Authors: Amitbhai Patel Harshal
Published: June 2024

Diuretics are a class of medication used to treat a variety of conditions, including heart failure, high blood pressure, glaucoma, liver and kidney disease, and fluid accumulation in the body. Physicians have been using them for many years; they are available in several forms, including potassium-sparing diuretics, thiazides, loop diuretics, carbonic anhydrase inhibitors, osmotic diuretics, and natural diuretics. On the other hand, frequent use of these diuretics may have some adverse effects. An electrolyte imbalance, blood pressure fluctuations, and treating disorders associated with fluid accumulation in the body are some examples of these side effects. In order to effectively manage a variety of medical disorders, healthcare practitioners must be aware of the proper use of diuretics and the significance of inducing diuresis, or the removal of excess fluid from the body. Healthcare practitioners can select the best courses of action and therapies for their patients by being knowledgeable about diuretics and how they function. Individuals can also make educated choices regarding the amount of fluids they consume, lifestyle modifications, and drugs to aid with diuresis and enhance their general health. This review article succinctly discusses the various applications for diuretics as well as any possible risks associated with encouraging diuresis.
Advancing Medical Diagnostics with Deep Learning and Data Preprocessing.
Authors: Xu Ruilin , Zi Yun , Dai Lu , Yu Haoran , Zhu Mengran
Published: June 2024

To address the inefficiencies and inaccuracies in analyzing large-scale medical diagnostic datasets, this paper introduces a deep learning-based method for processing auxiliary medical diagnostic data. The proposed approach involves preprocessing the medical diagnostic data through normalization and principal component analysis to extract relevant features. Subsequently, a neural network utilizing a multilayer perceptron is employed to analyze the preprocessed data, facilitating diagnostic classification. It also provides intelligent support for medical professionals. The method was implemented and tested using the Python programming environment. Results indicate that the proposed approach achieves better performance than other comparative methods and demonstrates significant practical application potential.
Advanced Energy Metering System Using IOT
Authors: Tripathi Santosh K , Maurya Swati , Kumar Ajeet , Raj Koshtubh S , Rawat Rajneesh
Published: June 2024

In recent times, there has been a swift advancement in the creation of smart cities. A smart city is a metropolitan area that makes use of cutting-edge technology for effective resource management and monitoring. The goal is to maximize energy and cost savings while simultaneously enhancing the quality of life for its citizens. With an emphasis on energy-related monitoring, a smart energy meter is the fundamental element that forms the basis for all data gathering, analysis, and automation. This paper describes how to turn a regular energy meter into a smart energy meter by adding an Arduino and a GSM module. With the help of the Internet of Things, this smart energy meter is further improved using IoT. An embedded controller (Arduino) and a GSM modem will be integrated by the smart energy meter system to transfer data over a GSM mobile network, such as generated invoices, spent energy in kWh, etc. IoT can be used to enable energy providers and power companies to monitor and control their customers' services without the need for human labour by providing them with the user -generated data. By connecting the smart meter to the Internet of Things, the user can access the data using a password and ID that has been issued from any location in the globe. Major energy companies will benefit from our project's user-friendliness, reduced labour costs, and decreased error and loss rates.
Toestemming patiënt vereist voor inzage dossier bij medische aansprakelijkheid
Authors: Simons J.P.M.
Published: June 2024

Mag een jurist van een ziekenhuis of diens aansprakelijkheidsverzekeraar in de buitengerechtelijke fase van een medische aansprakelijkheidskwestie zonder toestemming van de patiënt het medisch dossier inzien? HR 1 december 2023, ECLI:NL:HR:2023:1682

Het gaat in deze zaak om de vraag of een jurist van een ziekenhuis of diens aansprakelijkheidsverzekeraar zonder toestemming van de patiënt het medisch dossier van die patiënt mag inzien om een juridisch standpunt te kunnen innemen, wanneer die patiënt het ziekenhuis aansprakelijk heeft gesteld voor schade als gevolg van onzorgvuldig medisch handelen. De Hoge Raad oordeelt dat dit zonder toestemming van de patiënt niet mag. Daar staat tegenover dat het ziekenhuis of de betrokken hulpverlener, als de patiënt geen toestemming geeft en weigert een medische machtiging te ondertekenen die aan bepaalde minimale eisen voldoet, geen inhoudelijk standpunt hoeft in te nemen over de gestelde aansprakelijkheid.
Prophylaxis of venous thromboembolism in hospitalized patients admitted from Spanish emergency departments: the PROTESU II study
Authors: Rincón Díaz César , Jiménez Hernández Sonia , Beddar Chaib Fahd , Condon Abanto Ana Isabel , Cortés Ayaso María , Lozano Polo Laura , Guirado Torrecillas Leticia , Alonso Valle Héctor , Olid Velilla Mónica , Jiménez David , Lecumberri Ramón , Ruiz Artacho Pedro
Published: June 2024

Objetivos. Evaluar la inadecuación de la tromboprofilaxis farmacológica, según la escala Padua (PPS), para prevenir la enfermedad tromboembólica venosa (ETV) entre los pacientes que ingresan desde el servicio de urgencias hospitalario (SUH) por patología médica, así como las variables asociadas a su uso inadecuado. Método. Estudio de cohortes, prospectivo, multicéntrico donde participaron 15 SUH. Se incluyeron los pacientes atendidos que requirieron ingreso por enfermedad médica durante 7 días del primer trimestre de 2022. La inadecuación de la tromboprofilaxis farmacológica se definió como la no utilización en pacientes clasificados por PPS de alto riesgo sin contraindicaciones absolutas para su uso (hemorragia activa o trombopenia grave) o su utilización en pacientes de riesgo bajo o con contraindicaciones absolutas. Se ajustó, para cada grupo de riesgo, un modelo de regresión logística para identificar las variables asociadas a la inadecuación. Resultados. Se incluyeron 630 pacientes, 450 (71,4%) tenían riesgo alto y 180 (28,6%) riesgo bajo para ETV según la PPS. De ellos, la tromboprofilaxis fue inadecuada en 248 pacientes (39,4%) (165 tenían riesgo alto pero no recibieron tromboprofilaxis, 1 la recibió teniendo trombopenia grave y 82 tenían riesgo bajo pero recibieron tromboprofilaxis). Las variables asociadas con la inadecuación en pacientes de alto riesgo fueron trauma o cirugía recientes con odds ratio (OR) de OR 5,53 (IC 95%: 1,58-19,34), presencia de factores de riesgo hemorrágico con OR de 2,61 (IC 95%: 1,44-4,73), e infección del tracto urinario con OR de 2,29 (IC 95%: 1,07-4,87) y enfermedad gastrointestinal con OR de 4,30 (IC 95%: 1,71-10,85) como motivos de ingreso. Conclusiones. En los SUH españoles, el uso inadecuado de la tromboprofilaxis farmacológica es elevado. Algunas características clínicas se asocian al uso inadecuado de dicha tromboprofilaxis.
The Relationship between Political Image and Voting Behavior in First-time Voters: Demographics of Generation Z Voters in the 2024 Election in Indonesia
Authors:   Department of Psychology, Gunadarma University, Depok, Indonesia, Sitanggang Prasetyo Bonifasius , Ancok Djamaludin ,   Department of Psychology, Gunadarma University, Depok, Indonesia, Kuncoroyakti Yohanes Arie ,   Department of Communicaton Science, Gunadarma University, Depok, Indonesia, Lubis Ahmad Yazid ,   Department of Communicaton Science, Gunadarma University, Depok, Indonesia
Published: June 2024

Purpose: This research aims to determine the relationship between voting behavior and political image as well as the demographic characteristics of the voting behavior tendencies of Generation Z in the 2024 Election in Indonesia. Methods: Data collection uses a questionnaire that has good validity and reliability, the questionnaire contains a measurement scale for voting behavior and political image. The measurement of voting behavior variables uses a scale that includes aspects of knowledge, attitudes and actions. Meanwhile, the measurement of the political image variable uses a scale that includes aspects of competence, benevolence, integrity, fairness and reliability. Respondents are given alternative answers to choose one of the four answers provided starting from the options Strongly Agree to Strongly Disagree. Scoring for each answer choice for each variable is 1-4. Apart from that, the questionnaire also contains descriptive questions regarding respondents’ voting tendencies. The number of samples that met the criteria for first-time voter respondents was 453 respondents taken using a purposive sampling technique. The data analysis technique uses the Pearson Product Moment Correlation Test (r) which aims to determine the level of closeness of the relationship between variables which is expressed by the correlation coefficient (r). Results: The research results show a significant positive correlation between political image and voting behavior. The findings also show that the categorization of respondents’ political image is medium and the categorization of voting behavior is in the high category. The majority of respondents chose candidates based on their track record, ethnicity and religion, having a nationalist and religious image, and looking cool and trendy. Conclusion: The political image and voting behavior of Generation Z can be concluded to be correlated with each other. This research also shows how the candidate’s political image is desired by first-time voters.
KORELASI KEPRIBADIAN DENGAN KEMAMPUAN BERCERITA ANAK DI TK CINTA SEMUA KECAMATAN TUBAN
Authors: Apriliyana Firdausi Nuzula , Jaya Allan Firman , Marli'ah Siti
Published: June 2024

Anak beraktivitas tentu berkomunikasi dengan sesamanya melalui sarana berbicara yang dimilikinya. Agar lancar mengemukakan ide-ide atau gagasan-gagasan yang dihasilkannya Oleh sebab itu, kemampuan berbicara seseorang anak kecil harus dilatih. Hipotesis menunjukkan bahwa terdapat hubungan positif dan signifikan antara kepribadian dengan kemampuan bercerita. Hal ini diperoleh dari nilai koefisien korelasi sebesar 0.690. Nilai ini memberikan pengertian bahwa keterkaitan antara kepribadian dengan kemampuan bercerita adalah positif dan signifikan. Besarnya sumbangan   atau kontribusi variabel kepribadian terhadap kemampuan bercerita dapat diketahui dengan jalan mengkuadratkan nilai koefisien korelasi yang diperoleh, yaitu 0.6902 = 0.48. Secara statistik nilai ini memberikan pengertian bahwa 48% variasi kemampuan bercerita ditentukan oleh faktor kepribadian.
Exploring Khawaja Noor Muhammad Maharvi's Role in Spreading Islam and Spiritual Advancement in Bahawalpur Region
Authors: Javed Muhammad Tazeem , Shafiq Muhammad , Ilyas Moazam
Published: June 2024

Hazrat Khwaja Noor Muhammad Maharvi, a Sufi saint from Tehsil Chishtian, played a significant role in spreading Islamic teachings in the Bahawalpur region. He got his early education from Mahar Sharif, a small village near Chishtian. For higher education, he went to Dera Ghazi Khan, Lahore, Delhi, and Pakpatan. He pledged allegiance to his mentor, Shah Fakhruddin, in Pakpatan. On his return to Mahar Sharif, he took steps to spread Islam in the area. As a result, thousands of people benefited from his teachings. His caliphs and disciples started promoting religious education in their native areas. It is worth mentioning here that as a saint, Khwaja Sahib became famous and earned a high place in Punjab. Even Amir Bahawal Khan Abbasi II of Bahawalpur State was highly affiliated with him, and he was inspired by his teachings. Even the local people of South Punjab, especially the Bahawalpur region, have been blessed with his teachings and spiritual guidance. Nowadays, there is a madrasa, library, and a mosque adjacent to the Khanqah of Khawaja Noor Muhammad, where a number of students are acquiring religious knowledge. His Khanqah is a source of spiritual blessings and guidance for his devotees and the general public.
Suspensión Condicional de la Pena y Procedimiento Abreviado: Equilibrio entre Justicia y Eficiencia
Authors: Jácome-Aguilar Mireya Elizabeth , Choquicondor-Camacho Rafael Evaristo
Published: June 2024

La suspensión condicional de la pena y el procedimiento abreviado son herramientas clave en el sistema legal que buscan equilibrar la justicia y la eficiencia procesal. La primera permite que algunos condenados por delitos menores cumplan su sentencia en libertad bajo condiciones específicas, mientras que la segunda acelera la resolución de casos al aceptar el imputado su responsabilidad a cambio de una reducción de pena. Este equilibrio es esencial en sistemas judiciales y su correcta aplicación es necesaria para no afectar los derechos fundamentales de los acusados y la integridad del proceso judicial. El objetivo principal es analizar el pronunciamiento de la Corte Constitucional, mediante la sentencia 50-21 CN/22 y acumulado, la cual controla la constitucionalidad del Art. 630 del Código Orgánico Integral Penal sobre la suspensión condicional de la pena en un procedimiento abreviado, destacando la coexistencia de la legalidad, mínima intervención, igualdad, favorabilidad y legitimidad.
Full Time Equivalent Sebagai Acuan Dalam Penentuan Jumlah Tenaga Kerja
Authors: Wijaya Sananta Malde , Nugraha Robertus Bima Adhi , Setiawan Eko Agus
Published: June 2024

Fokus penelitian ini adalah mengevaluasi beban kerja menggunakan metode Full-Time Equivalent (FTE) untuk memahami kebutuhan ideal sumber daya manusia pada setiap tahap Pelaksanaan Promosi Jabatan Terbuka. Penelitian ini bertujuan untuk mengatasi masalah manajemen beban kerja karyawan dalam dinamika bisnis yang terus berubah di Biro Sumber Daya Manusia Perusahaan X. Analisis beban kerja menjadi penting karena meningkatnya kompleksitas tugas, kemajuan teknologi, dan tuntutan efisiensi operasional. Studi ini mengidentifikasi tujuh tahap utama Projab yang menjelaskan tugas, durasi, dan hasil kerja. Kebutuhan total tenaga kerja diperkirakan sekitar 2.22 FTE berdasarkan perhitungan FTE. Hal ini memungkinkan perusahaan untuk menjalankan proses dengan efisiensi penuh dengan menggunakan sekitar dua pekerja penuh waktu. Diharapkan hasil penelitian ini dapat membantu Perusahaan X dalam mengelola sumber daya manusia serta meningkatkan pemahaman tentang pendekatan FTE untuk analisis beban kerja.