bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of Waste Frying Oil and Crumb Rubber on the Characteristics of a Reclaimed Asphalt Pavement Binder
Authors: Bilema Munder , Aman Mohamad Yusri , Hassan Norhidayah Abdul , Al-Saffar Zaid , Mashaan Nuha S. , Memon Zubair Ahmed , Milad Abdalrhman , Yusoff Nur Izzi Md
Published: June 2021

The reclaimed asphalt pavement (RAP) has become a moderately common practice in most countries; Hence, rejuvenating materials with RAP have earned publicity in the asphalt manufacturers, mainly due to the increasing raw material costs. In this study, the crumb rubber (CR) and waste frying oil (WFO) utilized as waste materials to restore the properties and enhance the rutting resistance of the RAP. Several physical, rheological, chemical properties of bituminous binders were tested. The result showed that the RAP bituminous binders incorporating WFO and CR decreased softening points and the increased penetration value; these translate to an increase in penetration index. Moreover, the viscosity of the WFO/CR combination reclaimed asphalt pavement binder showed better workability and stiffness, as well as a low storage stability temperature (less than 2.2 °C) with an acceptable loss upon heating. Without chemical reaction was observed between the waste-frying oil with the rubberized binder and the reclaimed asphalt pavement binder. Additionally, the WFO/CR rheological properties combined with the reclaimed asphalt pavement binder were comparable to the control sample. The incorporation of CR with WFO as a hybrid rejuvenator enhanced the rutting resistance. Therefore, the presence of WFO/CR has a considerable influence on the RAP binder properties while preserving a better environment and reducing pollution by reusing waste materials.
Plant-Derived Colorants for Food, Cosmetic and Textile Industries: A Review
Authors: Brudzyńska Patrycja , Sionkowska Alina , Grisel Michel
Published: June 2021

This review provides a report on properties and recent research advances in the application of plant-derived colorants in food, cosmetics and textile materials. The following colorants are reviewed: Polyphenols (anthocyanins, flavonol-quercetin and curcumin), isoprenoids (iridoids, carotenoids and quinones), N-heterocyclic compounds (betalains and indigoids), melanins and tetrapyrroles with potential application in industry. Future aspects regarding applications of plant-derived colorants in the coloration of various materials are also discussed.
Adhesive Bonding of Copper Prepared by Laser-Interference near the Interference Structuring Limits
Authors: Liu Haotian , Weibel Justin A. , Sabau Adrian S. , Geoghegan Patrick , Chen Jian , Groll Eckhard A.
Published: June 2021

Adhesive bonding requires adequate surface preparation for ensuring an appropriate joint quality. The interest in adhesive joining has recently expanded to thermal systems having a large number of joints employed for manufacturing and assembly. This study presents surface topology of copper 110 produced by a laser-interference setup that would theoretically yield a periodicity of 1.7 μm, which is near the 1.6–2 μm structuring limit that was estimated based on thermal diffusion length scale for an 8 ns laser pulse. The results show that although the expected periodic interference structuring was not attained, the melt-induced texturing was affected by the laser-interference profile. Single-lap shear tests were performed with specimen surfaces prepared by traditional abrasion and laser-interference structuring methods. Several laser processing parameters, such as the laser spot size, density, number of pulses, and raster speed, were studied. Scanning electron microscope and profilometry measurements were used to characterize the processed surface microstructures. Web-like structures, which indicate widespread melting, were shown to be formed at different processing conditions. Based on the surface topologies investigated, two laser raster speeds were selected to make single-lap-joint specimens. Baseline joints were prepared by abrading joining specimens. The shear-lap strength and displacement at maximum load were shown to be higher by 16.8% and 43.8% for the laser-structured specimens than those of the baseline specimens, respectively. Moreover, the load-displacement curves indicated that the laser-structured joints were more ductile than those without laser-structuring. The increased ductility for the laser-structured joints was found to yield an increase in the energy absorbed during shear-lap testing of approximately of 80–90% over those measured for baseline joints. It is another indicator that laser-interference structuring enhanced the bonding performance of single-lap shear joints.
Development of 3D Models of Knits from Multi-Filament Ultra-Strong Yarns for Theoretical Modelling of Air Permeability
Authors: Ielina Tetiana , Halavska Liudmyla , Mikucioniene Daiva , Milasius Rimvydas , Bobrova Svitlana , Dmytryk Oksana
Published: June 2021

The work is devoted to the study of the geometric parameters of a knitted loop. It has been found that the optimal model is a loop model detailed at the yarn level, which considers the change in the cross-sectional shape and sets the properties of the porous material in accordance with the internal porosity of the yarn. A mathematical description of the coordinates of the characteristic points of the loop and an algorithm for calculating the coordinates of the control vertices of the second order spline, which determine the configuration of the yarn axes in the loop, are presented in this work. To create 3D models, Autodesk AutoCAD software and Structura 3D software, developed in the AutoLisp programming language, were used. The simulation of the air flow process was carried out in the Autodesk CFD Simulation environment. For the experimental investigation, plane knits from 44 tex × 3 linear density ultra-high molecular weight polyethylene yarns were produced, and their air permeability was tested according to Standard DSTU ISO 9237:2003. The results obtained during the laboratory experiment and simulation differed by less than 5%.
Ion Exchange Dynamics in Cerium Nitrate Solution Regulated by Remotely Activated Industrial Ion Exchangers
Authors: Jumadilov Talkybek , Yskak Laila , Imangazy Aldan , Suberlyak Oleg
Published: June 2021

Many technological solutions contain valuable components as waste and can become an additional source of rare-earth elements to meet the needs of modern production. The development of technologies based on commercially available and cheap sorbents reveals the possibility for rare earth recovery from various solutions. This paper provides research on using a combination of KU-2-8 and AV-17-8 ion exchangers in different molar ratios for cerium ions sorption from its nitrate solution. The mutual activation of the ion exchangers in an aqueous medium provides their transformation into a highly ionized state by the conformational and electrochemical changes in properties during their remote interaction. The ion exchange dynamics of solutions were studied by the methods of electrical conductivity, pH measurements, and atomic emission analysis of the solutions. The research showed that the maximum activation of polymers was revealed within the molar ratio of KU-2-8:AV-17-8 equal to 3:3. In more detail, in comparison to AV-17-8, this interpolymer system showed an increase in the sorption degree by more than 1.5 times after 6 h of interaction. Moreover, compared with KU-2-8, the same interpolymer system showed an increase in the degree of cerium ions sorption by seven times after 24 h of interaction. As a result, the total cerium ions sorption degree after 48 h of sorption by individual KU-2-8 and AV-17-8 was 38% and 44%, respectively, whereas the cerium ions sorption degree by the same interpolymer system in the molar ratio 3:3 became 51%. An increase in the sorption degree of cerium ions by the interpolymer system in comparison with individual ion exchangers can be explained by the achievement of a high ionization degree of ion exchangers being activated in the interpolymer system by the remote interaction effect.
A Sensaptic ADAS Device Using Shape Memory Alloy Wires: Design and Control
Authors: Ruth Deivamoney Josephine Selvarani , Dhanalakshmi Kaliaperumal , Choi Seung-Bok
Published: June 2021

This paper presents an active accelerator pedal system based on an integrated sensor and actuator using shape memory alloy (SMA) for speed control and to create haptics in the accelerator pedal. A device named sensaptics is developed with a pair of bi-functional SMA wires instrumented in a synergistic configuration function as an active sensor for positioning the accelerator pedal (pedal position sensing) to control the vehicle speed through electronic throttle and as a variable impedance actuator to generate active force (haptic) feedback to the driver. The reaction force emanated from the pedal alerts the driver and takes appropriate control action by slowing down the vehicle, in harmony with the road’s condition. The design is developed as a proof-of-concept device and is tested and evaluated in a real-time common rail diesel system for rail pressure regulation and over speeding tests, and the responses and performances are found to be promising.
Oxidized Alginate Dopamine Conjugate: In Vitro Characterization for Nose-to-Brain Delivery Application
Authors: Trapani Adriana , Corbo Filomena , Agrimi Gennaro , Ditaranto Nicoletta , Cioffi Nicola , Perna Filippo , Quivelli Andrea , Stefàno Erika , Lunetti Paola , Muscella Antonella , Marsigliante Santo , Cricenti Antonio , Luce Marco , Mormile Cristina , Cataldo Antonino , Bellucci Stefano
Published: June 2021

Background: The blood–brain barrier (BBB) bypass of dopamine (DA) is still a challenge for supplying it to the neurons of Substantia Nigra mainly affected by Parkinson disease. DA prodrugs have been studied to cross the BBB, overcoming the limitations of DA hydrophilicity. Therefore, the aim of this work is the synthesis and preliminary characterization of an oxidized alginate-dopamine (AlgOX-DA) conjugate conceived for DA nose-to-brain delivery. Methods: A Schiff base was designed to connect oxidized polymeric backbone to DA and both AlgOX and AlgOX-DA were characterized in terms of Raman, XPS, FT-IR, and 1H- NMR spectroscopies, as well as in vitro mucoadhesive and release tests. Results: Data demonstrated that AlgOX-DA was the most mucoadhesive material among the tested ones and it released the neurotransmitter in simulated nasal fluid and in low amounts in phosphate buffer saline. Results also demonstrated the capability of scanning near-field optical microscopy to study the structural and fluorescence properties of AlgOX, fluorescently labeled with fluorescein isothiocyanate microstructures. Interestingly, in SH-SY5Y neuroblastoma cell line up to 100 μg/mL, no toxic effect was derived from AlgOX and AlgOX-DA in 24 h. Conclusions: Overall, the in vitro performances of AlgOX and AlgOX-DA conjugates seem to encourage further ex vivo and in vivo studies in view of nose-to-brain administration.
Recent Advances in Fabrication of Non-Isocyanate Polyurethane-Based Composite Materials
Authors: Stachak Piotr , Łukaszewska Izabela , Hebda Edyta , Pielichowski Krzysztof
Published: June 2021

Polyurethanes (PUs) are a significant group of polymeric materials that, due to their outstanding mechanical, chemical, and physical properties, are used in a wide range of applications. Conventionally, PUs are obtained in polyaddition reactions between diisocyanates and polyols. Due to the toxicity of isocyanate raw materials and their synthesis method utilizing phosgene, new cleaner synthetic routes for polyurethanes without using isocyanates have attracted increasing attention in recent years. Among different attempts to replace the conventional process, polyaddition of cyclic carbonates (CCs) and polyfunctional amines seems to be the most promising way to obtain non-isocyanate polyurethanes (NIPUs) or, more precisely, polyhydroxyurethanes (PHUs), while primary and secondary –OH groups are being formed alongside urethane linkages. Such an approach eliminates hazardous chemical compounds from the synthesis and leads to the fabrication of polymeric materials with unique and tunable properties. The main advantages include better chemical, mechanical, and thermal resistance, and the process itself is invulnerable to moisture, which is an essential technological feature. NIPUs can be modified via copolymerization or used as matrices to fabricate polymer composites with different additives, similar to their conventional counterparts. Hence, non-isocyanate polyurethanes are a new class of environmentally friendly polymeric materials. Many papers on the matter above have been published, including both original research and extensive reviews. However, they do not provide collected information on NIPU composites fabrication and processing. Hence, this review describes the latest progress in non-isocyanate polyurethane synthesis, modification, and finally processing. While focusing primarily on the carbonate/amine route, methods of obtaining NIPU are described, and their properties are presented. Ways of incorporating various compounds into NIPU matrices are characterized by the role of PHU materials in copolymeric materials or as an additive. Finally, diverse processing methods of non-isocyanate polyurethanes are presented, including electrospinning or 3D printing.
Synthesis and Physicochemical Characterization of Novel Dicyclopropyl-Thiazole Compounds as Nontoxic and Promising Antifungals
Authors: Biernasiuk Anna , Banasiewicz Anna , Masłyk Maciej , Martyna Aleksandra , Janeczko Monika , Baranowska-Łączkowska Angelika , Malm Anna , Łączkowski Krzysztof Z.
Published: June 2021

There is a need to search for new antifungals, especially for the treatment of the invasive Candida infections, caused mainly by C. albicans. These infections are steadily increasing at an alarming rate, mostly among immunocompromised patients. The newly synthesized compounds (3a–3k) were characterized by physicochemical parameters and investigated for antimicrobial activity using the microdilution broth method to estimate minimal inhibitory concentration (MIC). Additionally, their antibiofilm activity and mode of action together with the effect on the membrane permeability in C. albicans were investigated. Biofilm biomass and its metabolic activity were quantitatively measured using crystal violet (CV) staining and tetrazolium salt (XTT) reduction assay. The cytotoxic effect on normal human lung fibroblasts and haemolytic effect were also evaluated. The results showed differential activity of the compounds against yeasts (MIC = 0.24–500 µg/mL) and bacteria (MIC = 125–1000 µg/mL). Most compounds possessed strong antifungal activity (MIC = 0.24–7.81 µg/mL). The compounds 3b, 3c and 3e, showed no inhibitory (at 1/2 × MIC) and eradication (at 8 × MIC) effect on C. albicans biofilm. Only slight decrease in the biofilm metabolic activity was observed for compound 3b. Moreover, the studied compounds increased the permeability of the membrane/cell wall of C. albicans and their mode of action may be related to action within the fungal cell wall structure and/or within the cell membrane. It is worth noting that the compounds had no cytotoxicity effect on pulmonary fibroblasts and erythrocytes at concentrations showing anticandidal activity. The present studies in vitro confirm that these derivatives appear to be a very promising group of antifungals for further preclinical studies.
Characterization and Combustion Behavior of Single-Use Masks Used during COVID-19 Pandemic
Authors: Szefer Ewa Maria , Majka Tomasz Mariusz , Pielichowski Krzysztof
Published: June 2021

This work aims to study the thermal degradation and combustion behavior of single-use masks commonly used during the COVID-19 pandemic. The sudden increase in plastic waste underlines the crucial need for a proper disposal method. Therefore, to develop a suitable method of thermal disposal, it is first necessary to identify the primary waste materials and then study their thermal and flammability behaviors using thermal analysis methods. This research focuses on the characterization of individual parts of the masks, their thermal degradation, and pyrolysis processes via FTIR, TG, and MCC analyses. FTIR analysis indicated that all three masks were made out of polypropylene sheets, while two of the ear straps contained polyamide 6. One of the samples was composed mainly of poly (ethylene terephthalate) fiber and thin inner EPDM rubber. The EPDM ear strap left the highest residue and showed the lowest flammability among all samples. The analysis of heat of combustion and thermogravimetry shows that the most heat is generated above 450 °C. Therefore, for the disposal of single-use masks to be effective, it should be carried out in the temperature range from 450 to 750 °C.
Numerical Simulation and Experimental Analysis of the Semi-Solid Thixotropic Extrusion Forming Process for Producing the Thin-Wall Wrought Aluminum Alloy Mobile Phone Shells
Authors: Guo Yi , Wang Yongfei , Zhao Shengdun
Published: June 2021

Aluminum alloys have been widely used in various engineering applications due to their excellent physical properties such as low density, high strength and good cutting capacity. In this paper, the semi-solid thixotropic extrusion forming process is proposed to produce aluminum alloy 6063 shells for mobile phones. The effects of the operating parameters on the equivalent stress distribution, velocity field, temperature field, and the load of the top mould were investigated through numerical simulations. Optimal parameters were identified from the simulation results. The experiment was then conducted at these optimal parameters. The macromorphology and microstructure results of the mobile phone shells produced from the experiment are presented and discussed. It was found that the optimal process parameters for preparing aluminum alloy 6063 shell by the semi-solid thixotropic extrusion process were a billet temperature of 630 °C, mould temperature of 400 °C, and top mould speed of 10 mm/s. It was found that the mobile phone shells fabricated under the optimal operating conditions were fully filled with a clear outline and a smooth surface. The solid grains in the microstructure were small, uniform and nearly spherical. The average grain size of the microstructure for the product was obtained as 76.92 μm and the average shape factor was found as 0.76.
The Influence of Enzymatic Hydrolysis of Whey Proteins on the Properties of Gelatin-Whey Composite Hydrogels
Authors: Popescu Violeta , Molea Andreia , Moldovan Marioara , Lopes Pompilia Mioara , Mazilu Moldovan Amalia , Popescu George Liviu
Published: June 2021

Amino-acids, peptides, and protein hydrolysates, together with their coordinating compounds, have various applications as fertilizers, nutritional supplements, additives, fillers, or active principles to produce hydrogels with therapeutic properties. Hydrogel-based patches can be adapted for drug, protein, or peptide delivery, and tissue healing and regeneration. These materials have the advantage of copying the contour of the wound surface, ensuring oxygenation, hydration, and at the same time protecting the surface from bacterial invasion. The aim of this paper is to describe the production of a new type of hydrogel based on whey protein isolates (WPI), whey protein hydrolysates (WPH), and gelatin. The hydrogels were obtained by utilizing a microwave-assisted method using gelatin, glycerol, WPI or WPH, copper sulfate, and water. WPH was obtained by enzymatic hydrolysis of whey protein isolates in the presence of bromelain. The hydrogel films obtained have been characterized by FT-IR and UV-VIS spectroscopy. The swelling degree and swelling kinetics have also been determined.
Theoretical and Experimental Analysis of the Hot Torsion Process of the Hardly Deformable 5XXX Series Aluminium Alloy
Authors: Laber Konrad Błażej , Leszczyńska-Madej Beata
Published: June 2021

This work presents the results of the numerical and physical modelling of the hot torsion of a hardly deformable 5XXX series aluminium alloy. Studies were conducted on constrained torsion with the use of the STD 812 torsion plastometer. The main purpose of the numerical tests was to determine the influence of the accuracy of the mathematical model describing the changes in the yield stress of the tested material on the distribution of strain parameters and on the stress intensity. According to the preliminary studies, in the case of numerical modelling of the torsion test, the accuracy of the applied mathematical model describing the changes in the rheological properties of the tested material and the correct definition of the initial and boundary conditions had a particularly significant impact on the correctness of the determination of the strain parameters and the intensity of stresses. As part of the experimental tests, physical modelling of the hot torsion test was conducted. The aim of this part of the work was to determine the influence of the applied strain parameters on the distribution and size of grain as well as the microhardness of the tested aluminium alloy. Metallographic analyses were performed using light microscopy and the electron backscatter diffraction method. Due to the large inhomogeneity of the deformation parameters and the stress intensity in the torsion test, such tests were necessary for the correct determination of the so-called representative area for metallographic analyses. These types of studies are particularly important in the case of the so-called complex deformation patterns. The paper also briefly presents the results of preliminary research and future directions in which it is planned to use complex deformation patterns for physical modelling of selected processes combining various materials.
Nonstationary Radiative–Conductive Heat Transfer Problem in a Semitransparent Body with Absolutely Black Inclusions
Authors: Amosov Andrey
Published: June 2021

The paper is devoted to a nonstationary initial–boundary value problem governing complex heat exchange in a convex semitransparent body containing several absolutely black inclusions. The existence and uniqueness of a weak solution to this problem are proven herein. In addition, the stability of solutions with respect to data, a comparison theorem and the results of improving the properties of solutions with an increase in the summability of the data were established. All results are global in terms of time and data.
Diversity and Antimicrobial Activity of Vietnamese Sponge-Associated Bacteria
Authors: Dat Ton That Huu , Cuc Nguyen Thi Kim , Cuong Pham Viet , Smidt Hauke , Sipkema Detmer
Published: June 2021

This study aimed to assess the diversity and antimicrobial activity of cultivable bacteria associated with Vietnamese sponges. In total, 460 bacterial isolates were obtained from 18 marine sponges. Of these, 58.3% belonged to Proteobacteria, 16.5% to Actinobacteria, 18.0% to Firmicutes, and 7.2% to Bacteroidetes. At the genus level, isolated strains belonged to 55 genera, of which several genera, such as Bacillus, Pseudovibrio, Ruegeria, Vibrio, and Streptomyces, were the most predominant. Culture media influenced the cultivable bacterial composition, whereas, from different sponge species, similar cultivable bacteria were recovered. Interestingly, there was little overlap of bacterial composition associated with sponges when the taxa isolated were compared to cultivation-independent data. Subsequent antimicrobial assays showed that 90 isolated strains exhibited antimicrobial activity against at least one of seven indicator microorganisms. From the culture broth of the isolated strain with the strongest activity (Bacillus sp. M1_CRV_171), four secondary metabolites were isolated and identified, including cyclo(L-Pro-L-Tyr) (1), macrolactin A (2), macrolactin H (3), and 15,17-epoxy-16-hydroxy macrolactin A (4). Of these, compounds 2-4 exhibited antimicrobial activity against a broad spectrum of reference microorganisms.
Autotrophic vs. Heterotrophic Cultivation of the Marine Diatom Cyclotella cryptica for EPA Production
Authors: Cupo Adelaide , Landi Simone , Morra Salvatore , Nuzzo Genoveffa , Gallo Carmela , Manzo Emiliano , Fontana Angelo , d’Ippolito Giuliana
Published: June 2021

Recently, the marketable value of ω-3 fatty acid, particularly eicosapentaenoic acid (EPA), increased considering their health effects for human consumption. Microalgae are considered a valuable and “green” source of EPA alternative to fish oils, but considerable efforts are necessary for their exploitation at an industrial level. Due to the high operation costs of photoautotrophic microalgae cultivation, heterotrophic growth represents a promising economic solution. Marine diatoms are the major ecological producers of ω-3 fatty acids. Few species of diatoms are capable to grow in the dark using organic carbon sources. The marine diatom Cyclotella cryptica was cultivated for 14 days under photoautotrophic and heterotrophic conditions to define the effects on growth parameters, lipid production, total fatty acids and EPA content. Photoautotrophic conditions led to a total EPA production of 1.6% of dry weight, 12.2 mg L−1 culture and productivity of 0.9 mg L−1 day−1. The heterotrophy cultures reported a total EPA production of 2.7% of dry cell weight, 18 mg L−1 culture, a productivity of 1.3 mg L−1 day−1, which are promising values in the prospective of improving culture parameters for the biotechnological exploitation of dark cultivation. C. cryptica could be a potential candidate for the heterotrophic production of EPA, also considering its robustness, capacity to resist to bacterial contaminations and plasticity of lipid metabolism.
Seaweed Components as Potential Modulators of the Gut Microbiota
Authors: Shannon Emer , Conlon Michael , Hayes Maria
Published: June 2021

Macroalgae, or seaweeds, are a rich source of components which may exert beneficial effects on the mammalian gut microbiota through the enhancement of bacterial diversity and abundance. An imbalance of gut bacteria has been linked to the development of disorders such as inflammatory bowel disease, immunodeficiency, hypertension, type-2-diabetes, obesity, and cancer. This review outlines current knowledge from in vitro and in vivo studies concerning the potential therapeutic application of seaweed-derived polysaccharides, polyphenols and peptides to modulate the gut microbiota through diet. Polysaccharides such as fucoidan, laminarin, alginate, ulvan and porphyran are unique to seaweeds. Several studies have shown their potential to act as prebiotics and to positively modulate the gut microbiota. Prebiotics enhance bacterial populations and often their production of short chain fatty acids, which are the energy source for gastrointestinal epithelial cells, provide protection against pathogens, influence immunomodulation, and induce apoptosis of colon cancer cells. The oral bioaccessibility and bioavailability of seaweed components is also discussed, including the advantages and limitations of static and dynamic in vitro gastrointestinal models versus ex vivo and in vivo methods. Seaweed bioactives show potential for use in prevention and, in some instances, treatment of human disease. However, it is also necessary to confirm these potential, therapeutic effects in large-scale clinical trials. Where possible, we have cited information concerning these trials.
Evaluation of the Effectiveness of Helicobacter pylori Eradication Regimens in Lithuania during the Years 2013–2020: Data from the European Registry on Helicobacter pylori Management (Hp-EuReg)
Authors: Jonaitis Paulius , Kupcinskas Juozas , Nyssen Olga P. , Puig Ignasi , Gisbert Javier P. , Jonaitis Laimas
Published: June 2021

Background and Objectives: The prevalence of H. pylori in Eastern Europe remains quite high; however, there is insufficient data on the eradication regimens and their effectiveness. Therefore, the objective of the study was to evaluate the diagnostic methods and treatment of H. pylori infection as well as their adherence to Maastricht V/Florence consensus during the years 2013–2020 in Lithuania. Materials and Methods: Sub-study of the “European Registry on H. pylori Management” (Hp-EuReg), international multicenter prospective non-interventional registry of the routine clinical practice. Lithuanian data from the years 2013–2020 were analyzed for effectiveness on a modified intention-to-treat (mITT) basis. 2000 adult patients, diagnosed with H. pylori infection, were included. Data were compared to the European Maastricht V guidelines. Results: Triple-therapy was used in 90% of the cases. In 91% of the first-line prescriptions, standard triple therapy (STT) was used. The most common second-line treatment was a combination of PPI, amoxicillin and levofloxacin (PPI+A+L) (47%). The overall effectiveness in 552 cases valid for analysis was 90% by mITT. In first-line treatment, the STT effectiveness was 90% and second-line treatment with PPI+A+L achieved 92% by mITT. Increasing overall H. pylori eradication rates were observed: from 72% in 2013 to more than 90% in 2018–2020, as well as a shift from 7 to 10–14 days treatments duration throughout 2013–2020. Conclusions: In Lithuania, the prescribed eradication regimens for H. pylori were in accordance with the international guidelines but diagnostic methods and treatment duration only partially met Maastricht V/Florence guidelines. The eradication effectiveness was improved progressively during the years 2018–2020, reaching ≥90% cure rates.
In-Season Internal and External Workload Variations between Starters and Non-Starters—A Case Study of a Top Elite European Soccer Team
Authors: Oliveira Rafael , Palucci Vieira Luiz H. , Martins Alexandre , Brito João Paulo , Nalha Matilde , Mendes Bruno , Clemente Filipe Manuel
Published: June 2021

Background and Objectives: Interpretation of the load variations across a period seems important to control the weekly progression or variation of the load, or to identify in-micro- and mesocycle variations. Thus, the aims of this study were twofold: (a) to describe the in-season variations of training monotony, training strain and acute:chronic workload ratio (ACWR) through session ratings of perceived exertion (s-RPE), total distance and high-speed running (HSR); and (b) to compare those variations between starters and non-starters. Materials and Methods: Seventeen professional players from a European First League team participated in this study. They were divided in two groups: starters (n = 9) and non-starters (n = 8). The players were monitored daily over a 41-week period of competition where 52 matches occurred during the 2015–2016 in-season. Through the collection of s-RPE, total distance and HSR, training monotony, training strain and ACWR were calculated for each measure, respectively. Data were analyzed across ten mesocycles (M: 1 to 10). Repeated measures ANOVA was used with the Bonferroni post hoc test to compare M and player status. Results: The results revealed no differences between starters vs. non-starters (p > 0.05). M6 had a greater number of matches and displayed higher values for monotony (s-RPE, total distance and HSR), strain (only for total distance) and ACWR (s-RPE, TD and HSR). However, the variation patterns for all indexes displayed some differences. Conclusions: The values of both starters and non-starters showed small differences, thus suggesting that the adjustments of training workloads that had been applied over the season helped to reduce differences according to the player status. Even so, there were some variations over the season (microcycles and mesocycles) for the whole team. This study could be used as a reference for future coaches, staff and scientists.
Medical Care Situation of People with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome in Germany
Authors: Froehlich Laura , Hattesohl Daniel B. R. , Jason Leonard A. , Scheibenbogen Carmen , Behrends Uta , Thoma Manuel
Published: June 2021

Background and Objective: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a severe illness with the hallmark symptom of Post-Exertional Malaise (PEM). Currently, no biomarkers or established diagnostic tests for ME/CFS exist. In Germany, it is estimated that over 300,000 people are affected by ME/CFS. Research from the United States and the UK shows that patients with ME/CFS are medically underserved, as they face barriers to medical care access and are dissatisfied with medical care. The first aim of the current research was to investigate whether patients with ME/CFS are medically underserved in Germany in terms of access to and satisfaction with medical care. Second, we aimed at providing a German-language version of the DePaul Symptom Questionnaire Short Form (DSQ-SF) as a tool for ME/CFS diagnostics and research in German-speaking countries. Materials and Methods: The current research conducted an online questionnaire study in Germany investigating the medical care situation of patients with ME/CFS. The questionnaire was completed by 499 participants who fulfilled the Canadian Consensus Criteria and reported PEM of 14 h or longer. Results: Participants frequently reported geographic and financial reasons for not using the available medical services. Furthermore, they reported low satisfaction with medical care by the physician they most frequently visited due to ME/CFS. The German version of the DSQ-SF showed good reliability, a one-factorial structure and construct validity, demonstrated by correlations with the SF-36 as a measure of functional status. Conclusions: Findings provide evidence that patients with ME/CFS in Germany are medically underserved. The German-language translation of the DSQ-SF provides a brief, reliable and valid instrument to assess ME/CFS symptoms to be used for research and clinical practice in German-speaking countries. Pathways to improve the medical care of patients with ME/CFS are discussed.
Potential Pitfalls in Membrane Fouling Evaluation: Merits of Data Representation as Resistance Instead of Flux Decline in Membrane Filtration
Authors: Blankert Bastiaan , Van der Bruggen Bart , Childress Amy E. , Ghaffour Noreddine , Vrouwenvelder Johannes S.
Published: June 2021

The manner in which membrane-fouling experiments are conducted and how fouling performance data are represented have a strong impact on both how the data are interpreted and on the conclusions that may be drawn. We provide a couple of examples to prove that it is possible to obtain misleading conclusions from commonly used representations of fouling data. Although the illustrative example revolves around dead-end ultrafiltration, the underlying principles are applicable to a wider range of membrane processes. When choosing the experimental conditions and how to represent fouling data, there are three main factors that should be considered: (I) the foulant mass is principally related to the filtered volume; (II) the filtration flux can exacerbate fouling effects (e.g., concentration polarization and cake compression); and (III) the practice of normalization, as in dividing by an initial value, disregards the difference in driving force and divides the fouling effect by different numbers. Thus, a bias may occur that favors the experimental condition with the lower filtration flux and the less-permeable membrane. It is recommended to: (I) avoid relative fouling performance indicators, such as relative flux decline (J/J0); (II) use resistance vs. specific volume; and (III) use flux-controlled experiments for fouling performance evaluation.
Tanning Wastewater Treatment by Ultrafiltration: Process Efficiency and Fouling Behavior
Authors: Yang Fu , Huang Zhengkun , Huang Jun , Wu Chongde , Zhou Rongqing , Jin Yao
Published: June 2021

Ultrafiltration is a promising, environment-friendly alternative to the current physicochemical-based tannery wastewater treatment. In this work, ultrafiltration was employed to treat the tanning wastewater as an upstream process of the Zero Liquid Discharge (ZLD) system in the leather industry. The filtration efficiency and fouling behaviors were analyzed to assess the impact of membrane material and operating conditions (shear rate on the membrane surface and transmembrane pressure). The models of resistance-in-series, fouling propensity, and pore blocking were used to provide a comprehensive analysis of such a process. The results show that the process efficiency is strongly dependent on the operating conditions, while the membranes of either PES or PVDF showed similar filtration performance and fouling behavior. Reversible resistance was the main obstacle for such process. Cake formation was the main pore blocking mechanism during such process, which was independent on the operating conditions and membrane materials. The increase in shear rate significantly increased the steady-state permeation flux, thus, the filtration efficiency was improved, which resulted from both the reduction in reversible resistance and the slow-down of fouling layer accumulate rate. This is the first time that the fouling behaviors of tanning wastewater ultrafiltration were comprehensively evaluated, thus providing crucial guidance for further scientific investigation and industrial application.
Antibacterial and In Vivo Studies of a Green, One-Pot Preparation of Copper/Zinc Oxide Nanoparticle-Coated Bandages
Authors: Deokar Archana R. , Perelshtein Ilana , Saibene Melissa , Perkas Nina , Mantecca Paride , Nitzan Yeshayahu , Gedanken Aharon
Published: June 2021

Simultaneous water and ethanol-based synthesis and coating of copper and zinc oxide (CuO/ZnO) nanoparticles (NPs) on bandages was carried out by ultrasound irradiation. High resolution-transmission electron microscopy demonstrated the effects of the solvent on the particle size and shape of metal oxide NPs. An antibacterial activity study of metal-oxide-coated bandages was carried out against Staphylococcus aureus (Gram-positive) and Escherichia coli (Gram-negative). CuO NP-coated bandages made from both water and ethanol demonstrated complete killing of S. aureus and E. coli bacteria within 30 min., whereas ZnO NP-coated bandages demonstrated five-log reductions in viability for both kinds of bacteria after 60 min of interaction. Further, the antibacterial mechanism of CuO/ZnO NP-coated bandages is proposed here based on electron spin resonance studies. Nanotoxicology investigations were conducted via in vivo examinations of the effect of the metal-oxide bandages on frog embryos (teratogenesis assay—Xenopus). The results show that water-based coatings resulted in lesser impacts on embryo development than the ethanol-based ones. These bandages should therefore be considered safer than the ethanol-based ones. The comparison between the toxicity of the metal oxide NPs prepared in water and ethanol is of great importance, because water will replace ethanol for bulk scale synthesis of metal oxide NPs in commercial companies to avoid further ignition problems. The novelty and importance of this manuscript is avoiding the ethanol in the typical water:ethanol mixture as the solvent for the preparation of metal oxide NPs. Ethanol is ignitable, and commercial companies are trying the evade its use. This is especially important these days, as the face mask produced by sonochemistry (SONOMASK) is being sold all over the world by SONOVIA, and it is coated with ZnO.
Alkaline Liquid Ventilation of the Membrane Lung for Extracorporeal Carbon Dioxide Removal (ECCO2R): In Vitro Study
Authors: Vivona Luigi , Battistin Michele , Carlesso Eleonora , Langer Thomas , Valsecchi Carlo , Colombo Sebastiano Maria , Todaro Serena , Gatti Stefano , Florio Gaetano , Pesenti Antonio , Grasselli Giacomo , Zanella Alberto
Published: June 2021

Extracorporeal carbon dioxide removal (ECCO2R) is a promising strategy to manage acute respiratory failure. We hypothesized that ECCO2R could be enhanced by ventilating the membrane lung with a sodium hydroxide (NaOH) solution with high CO2 absorbing capacity. A computed mathematical model was implemented to assess NaOH–CO2 interactions. Subsequently, we compared NaOH infusion, named “alkaline liquid ventilation”, to conventional oxygen sweeping flows. We built an extracorporeal circuit with two polypropylene membrane lungs, one to remove CO2 and the other to maintain a constant PCO2 (60 ± 2 mmHg). The circuit was primed with swine blood. Blood flow was 500 mL × min−1. After testing the safety and feasibility of increasing concentrations of aqueous NaOH (up to 100 mmol × L−1), the CO2 removal capacity of sweeping oxygen was compared to that of 100 mmol × L−1 NaOH. We performed six experiments to randomly test four sweep flows (100, 250, 500, 1000 mL × min−1) for each fluid plus 10 L × min−1 oxygen. Alkaline liquid ventilation proved to be feasible and safe. No damages or hemolysis were detected. NaOH showed higher CO2 removal capacity compared to oxygen for flows up to 1 L × min−1. However, the highest CO2 extraction power exerted by NaOH was comparable to that of 10 L × min−1 oxygen. Further studies with dedicated devices are required to exploit potential clinical applications of alkaline liquid ventilation.
Microstructural and Cavitation Erosion Behavior of the CuAlNi Shape Memory Alloy
Authors: Volkov-Husović Tatjana , Ivanić Ivana , Kožuh Stjepan , Stevanović Sanja , Vlahović Milica , Martinović Sanja , Stopic Srecko , Gojić Mirko
Published: June 2021

Microstructural and cavitation erosion testing was carried out on Cu-12.8Al-4.1Ni (wt. %) shape memory alloy (SMA) samples produced by continuous casting followed by heat treatment consisting of solution annealing at 885 °C for 60 min and, later, water quenching. Cavitation resistance testing was applied using a standard ultrasonic vibratory cavitation set up with stationary specimen. Surface changes during the cavitation were monitored by metallographic analysis using an optical microscope (OM), atomic force microscope (AFM), and scanning electron microscope (SEM) as well as by weight measurements. The results revealed a martensite microstructure after both casting and quenching. Microhardness value was higher after water quenching than in the as-cast state. After 420 min of cavitation exposure, a negligible mass loss was noticed for both samples. Based on the obtained results, both samples showed excellent cavitation resistance. Mass loss and morphological analysis of the formed pits indicated better cavitation resistance for the as-cast state (L).
Mechanical and Microstructural Properties of A36 Marine Steel Subjected to Underwater Wet Welding
Authors: Surojo Eko , Aji Raka Pungkas , Triyono Triyono , Budiana Eko Prasetya , Prabowo Aditya Rio
Published: June 2021

Underwater wet welding (UWW) is applied to repair basic offshore structures, underwater pipelines, water transportation, docks, and port equipment. The underwater wet welding method used in the current research was shield metal arc welding (SMAW), and this was conducted on an A36 steel plate. We investigated the effect of a water temperature of 10 ± 5 °C and different types of water flow (without flow, non-uniform flow with baffle bulkhead, and non-uniform flow without baffle bulkhead). The defects found on the specimen included spattering, irregular surfaces, porosity, and undercutting. A high cooling rate led to the formation of more acicular ferrite (AF) phases in the weld metal area than a slow cooling rate. The microstructure of the heat affected zone (HAZ) area led to the formation of finer and small grains. Values of tensile, impact, and hardness strength were greater with higher cooling rates. The highest tensile strength value was 585.09 MPa, and this occurred with non-uniform flow without a baffle bulkhead. The highest values of absorbed energy and impact strength were 41.9 J and 2.05 J/mm2, respectively, and these occurred with a non-uniform flow without a baffle bulkhead. The greatest hardness values were found with a non-uniform flow without a baffle bulkhead in the weld metal area.
Numerical Investigation of Thermo-Mechanical Field during Selective Laser Melting Process with Experimental Validation
Authors: Li Lan , Liou Frank
Published: June 2021

In this study, thermo-mechanical simulation was conducted to predict thermal and stress behavior in Selective Laser Melting (SLM). Temperature-dependent material properties for processed material 304L stainless steel were incorporated into the model in order to capture the change from powder to fully dense solid stainless steel. Temperature and thermal stress history were tracked under conditions of different parameter sets which were designed to reduce defect formation. The thermal model predicted the temperature history for multi-track scans under different process parameters, such as laser power, effective scanning speed and hatch spacing. Subsequently, the corresponding melt-pool size, solidification rate and temperature gradients could be calculated from simulated temperature data. These three parameters from the simulation were compared with experimental melt pool size, grain structure and cell spacing data obtained from a Renishaw AM250. The experimental data were also used to determine unknown simulation parameters required by the continuum model, e.g., the optical penetration depth and thermal conductivity multiplier for the molten region. This allowed the simulation model to accurately predict melt pool size and solidification structure of SLM 304L stainless steel. Simulated stress showed that the subsequent thermal cyclic melting in successive scanned tracks resulted in alternating compressive and tensile thermal stresses. This work will provide insight for studying microstructure morphology, residual stress and deformations in the SLM process of 304L stainless steel.
Effect of Post-Heat Treatment Cooling Conditions on Microstructures and Fatigue Properties of Cobalt Chromium Molybdenum Alloy Fabricated through Selective Laser Melting
Authors: Wai Cho Hla Htoot , Takaichi Atsushi , Kajima Yuka , Htat Hein Linn , Kittikundecha Nuttaphon , Hanawa Takao , Wakabayashi Noriyuki
Published: June 2021

Although post-heat treatment can improve the fatigue life of selective laser melting (SLM)-fabricated cobalt chromium molybdenum (CoCrMo) alloys, the effect of cooling conditions on the fatigue properties of such alloys remains unclear. In this study, we fabricated SLM CoCrMo alloy specimens and, after heat-treating them, cooled them either via furnace-cooling (FC) or air-cooling (AC). Subsequently, we analyzed their microstructures using scanning electron microscopy combined with energy-dispersive X-ray spectroscopy, electron backscattered diffraction, confocal laser scanning microscopy, and X-ray diffraction. Tensile and Vickers hardness (HV) tests and axial-fatigue tests were also conducted to assess their mechanical and fatigue properties, respectively. The microstructures of all samples showed homogeneous equiaxed grains, with the grains and precipitates of the AC samples (grain size: 84.9 μm) smaller than those of the FC samples (grain size: 109.7 μm). The AC samples exhibited better ductility than the FC samples. However, we observed no significant differences in the 0.2% yield strength and HV tests. The S–N curve derived from the fatigue tests showed that the AC samples had greater fatigue life than the FC samples. Therefore, a high cooling rate during post-heat treatment is effective in reducing grain and precipitate sizes, resulting in improved ductility and fatigue life.