bluuebunny/crossref_metadata_2025 huggingface dataset:
Pathogenetic aspects of the drug in the treatment of glaucoma Cortexin optic neuropathy
Authors: Radchenko J.
Published: February 2019

Glaucoma is one of the first places among the causes of blindness and visual disability in the world. Currently, glaucoma is not treated as an isolated ocular pathology as well as a manifestation of the general exchange violations and neurovascular disorders in the body. The article presents the etiology and pathogenesis of glaucomatous optic neuropathy. Microcirculatory disorders observed in the form of a narrowing of the arteries and reduce the resulting perfusion pressure, the development of capillary stasis and rheological disorders (increased aggregation of red blood cells, reducing their ability to deformation). All this subsequently leads to local metabolic disorders. It is also an important role in the pathological chain may be joining vasospasm. The results of Cortexin use in various forms of glaucoma in both monotherapy and in treatment. Cortexin use in various forms of glaucoma as a monotherapy and in treatment. Cortexin peptide bioregulators, which reduces neuronal apoptosis, provides a neuroprotective and neurotrophic effects.
Approaches to the complex treatment of patients with multiple sclerosis in terms of comorbidity using reflexology techniques
Authors: Chupryna G.M.
Published: February 2019

The article raises questions of integrated approaches to the treatment of multiple sclerosis according to the flow of the main pathological process and the type of comorbid pathology. We discuss the feasibility of applying the methods of acupuncture in the complex treatment and rehabilitation measures.
Strokes the actual direction of cardioneurology
Authors: Trufanov E.A.
Published: February 2019

Cardioneurology solves a number of urgent clinical problems that require consolidation of efforts of cardiology, neurology, vascular surgeons, interventional medicine, representatives ray, functional and laboratory diagnostics. The high level of specialization of modern medicine, reflecting the divergence optionally-depth knowledge in a growing amount of in-formation is not contrary to the current trend, the study of complex most pressing problems.
Clinical case: criteria for differential diagnosis and treatment of chronic inflammatory demyelinating polyneuropathy
Authors: Kravchuk N.O.
Published: February 2019

Chronic inflammatory demyelinating polyneuropathy (CIDP) is a rare neurological disease that is characterized by inflammation of nerve roots and peripheral nerves, nerve destruction of the myelin sheath, the appearance of slowly-progressive symmetric symptoms, motor and sensory disorders. CIDPsometimes considered a chronic form of acute inflammatory demyelinating polyneuropathy (АIDP) - Guillain Barré syndrome (GBS). In contrast to GBS, most patients do not mark HDPNP previous viral or infectious disease. CIDP is subacute-progressive disease that clinically takes 3-4 weeks, then usually comes plateau phase, which changes the phase of gradual regression of symptoms. CIDP can affect any age group. CIDP registered twice as often in men. The average age of onset of the disease is 50 years. CIDP prevalence is estimated at about 5-7 cases per 100 thousand people.
Strategy for the treatment of cognitive disorders in patients with chronic brain ischemia and initial manifestations of insufficient blood supply to the brain
Authors: Svyrydova N.K. , Pavliuk N.P.
Published: February 2019

Cerebrovascular accidents are the most important med- ical and social problem due to their high frequency in the structure of morbidity and mortality, as well as significant indicators of disability in the population. The severity of cognitive deficits in patients with cerebrovascular disease are more correlated not with territorial infarcts caused by the defeat of the major cerebral arteries, and on microvascular pathology (a minor heart attack, multiple lacunar infarcts, microbleeds), as well as cerebral atrophy, which may be due to vascular brain damage and specific neurodegenerative process. Since effective therapeutic drugs treat persistent cognitive impairment in the present does not exist, an alternative could be a strategy of weakening of cognitive impairment and their progression. The article describes the characteristics, the description of the results of worldwide research application components that are complex and herbal preparations Memokor Neokardil.
Радикулопатії і безсимптомні грижі хребта: диференційна діагностика і лікування
Authors: Svyrydova N.
Published: February 2019

Походження хронічного болю в спині часто припускає розвиток дегенеративних процесів хребта, проте, дослідження показали, що в більшості випадків кореляція між клінічними симптомами і рентгенологічними ознаками дегенерації мінімальна або відсутня. Клінічні ознаки, які повинні насторожити лікаря, вимагають ретельної диференційної діагностики. Рекомендації FDA для лікування нейропатичного болю звертають увагу на побічні ефекти при прийомі всієї групи препаратів, з урахуванням коморбідної патології пацієнта. Проте, враховуючи, що тільки габапентин і прегабалін мають переконливі докази ефективності при невропатичному болю, то акцент зроблений на ці препарати.
The Tourette’s syndrome: clinical case
Authors: Svyrydova N.K. , Trufanov Y.O. , Artemenko A.V. , Rakhnianska A.M. , Schurevskyy S.O.
Published: February 2019

Tourette’s Syndrome (TS) — is the complex of symptoms of affection of the central nervous system, characterized by paroxysmal (rarely permanent) tic muscle twitching of face, neck, upper and lower extremities, hyperkinesia of respiratory muscles and facial muscles with involuntary exclamations of impulsive individual sounds or words [1]. The disease has an autosomal recessive inheritance and with disease onset in children aged 2 to 14 years, and boys get sick 2-3 times more likely than girls. Pathology does not affect life expectancy and mental development [2].

This article describes a case of clinical practice follow up female patient with Tourette's syndrome. The attention is focused on the methods of examination and differential diagnosis of this disease. TS’s studies has a perspective in creation of evidence base, early detection and treatment, also in prevention of underdiagnosis of this pathology.
Розсіяний склероз: етіологія, патоґенез, клініка, діагностика, лікування (клінічна лекція)
Authors: Chupryna G. , Svyrydova N.
Published: February 2019

Останнє десятиріччя характеризувалось введенням значної кількості нових препаратів та методів патогенетичного лікування РС, які показали можливі перспективи позитивного впливу на перебіг захворювання, проте найбільш значущими визнані питання чіткої організації спеціалізованої допомоги хворим на РС, та розширення механізмів керування захворюванням, в тому числі створення ефективної системи виявлення хворих, вчасне виявлення і лікування екзацербацій, їх профілактика та попередження прогресування, проведення реабілітаційних заходів, лікування коморбідних захворювань, що є істотним резервом збільшення ефективності лікування, запобігання інвалідизації хворих та збереження спроможності  до самообслуговання.
The influence of the autonomic nervous system in the development of chronic heart failure in patients with chronic brain ischemia combined with myocardial infarction
Authors: Kravchuk N. O.
Published: February 2019

Heart failure - severe, common clinical syndrome that is the result of many heart diseases is progressive, significantly reduces the life expectancy of patients and impairs its quality.

Leading nosological forms the structure of coronary heart disease for many years, is a myocardial infarction. Growing proportion of elderly in most populations, increased survival after acute myocardial infarction (AMI) resulted in a significant increase in the number of patients with chronic heart failure (CHF).

Increased tone of the sympathetic division precedes the development of chronic cerebral ischemia and, therefore, may complicate the course of disease in the presence of chronic heart failure.
Всеукраїнська науково-практична конференція молодих вчених «Біль – сучасні аспекти діагностики та лікування» (15-17 січня 2016 р., с. Ізки, Закарпатська область, Україна)
Authors: Board Editorial
Published: February 2019

В роботі конференції взяли участь науковці кафедр НМАПО імені П.Л.Шупика: неврології та рефлексотерапії, неврології №1, стоматології, сімейної медицини та амбулаторно-поліклінічної допомоги, стоматологічного центру НМАПО імені П.Л.Шупика (м. Київ), ДУ «Національний інститут раку» (м. Київ), Львівського національного медичного університету імені Данила Галицького (м. Львів), ДУ «НІССХ імені М.М. Амосова (м. Київ), Вінницького національного медичного університету імені М. І. Пірогова (м. Вінниця), Львівської обласної клінічної дитячої лікарні (м. Львів), Республіканської лікарні "ОХМАТДИТ" (м. Київ), Клінічної лікарні «Феофанія» (м. Київ). На конференції розглядались актуальні питання лікування больових синдромів різного ґенезу та локалізації з позицій доказової медицини та згідно існуючих в Україні та світі протоколів лікування. Доповідачі ознайомили учасників заходу з сучасними методами знеболювання при онкологічній патології та проведення реґіонарної анестезії при оперативних втручаннях, підкреслили роль реабілітації при розвитку вертеброгенної патології.
The risk of stroke in patients with dizziness
Authors: Svyrydova N.
Published: February 2019

Primary prevention of cerebrovascular diseases is not realized, developed aspect of the program, such as dietary habits, blood pressure control, lipid concentrations, assessment of metabolic disorders - are not used as a single unit. The first step in the solving of this problem, the main recommendation of the Guide to the primary prevention of CVD which based on the fact that the risk of disease should be evaluated for all patients on the basis of a careful study of medical history, physical examination, and the results of certain lab tests. The determina-tion monitoring purposes of different risk factors with the obligatory account of individual risk factors - it is one of the advantages in identifying those who have a higher risk of developing cerebral accidents.Proved that to the high-risk group of stroke include the patients with vertigo (other neurologic symptoms), especially men of middle and old age. Furthermore, during the imaging of the brain in most patients with dizziness have been identified unexpressed signs of a lesion of the barrel or the cerebellum, which resemble the clinical manifestations of peripheral vestibular disorders. Recent studies have shown that the dizziness is often a basic of vestibular dysfunctions that lead to the development of acute cerebral ischemia. The importance of the influence of vestibular physiology, affective neuroscience and so-cial neuroscience require a correction of manifestations of dizziness, as a factor in the risk of stroke by Citoflavin drug has a pronounced antiischemic and antioxidant effect, significantly preventing the build-up of ischemic damage to brain tissue. Drug, including in biochemical power shunt, helps to prevent unwanted effects that are typical of ischemic tissue to stabilize the work of their own antioxidant systems.
Features of pain syndromes in patients with multiple sclerosis in the aspect of comorbidity
Authors: Chuprуna G. , Svyrydova N. , Petrenko N.
Published: February 2019

We studied the prevalence of pain syndromes (РS) in patients with multiple sclerosis (MS) in order to clarify the characteristics of their occurrence and the extent of impact on quality of life, level of fatigue and depression in terms of comorbidity. The study involved 207 MS patients with different forms of course. Evaluated the clinical and demographic characteristics of the patients with MS due to comorbidity, conducted multidimensional assessment of pain using the McGill Pain Questionnaire, determines the level of EDSS, the severity of pain (VAS), the severity of fatigue (FSS), depression (BDI-II), quality of life (SF-36). The average prevalence of РS in all our study patients with MS was 76,3%. It was found that a РS in MS patients are more prevalent in patients with comorbid pathology.
Neurolues: the clinical case
Authors: Kysil’ V. , Nechkaluk M. , Drigant L. , Sereda V.
Published: February 2019

Neurosyphilis -  chronic, progressive infection of the central nervous system of humans. The development of the pathology caused by penetration of the body causative agent of syphilis - Treponema pale. Syphilis affects all parts of the central and peripheral nervous system, and the clinical picture of the disease is manifested by a number of neurological symptoms. Today syphilis treated well, but if we are dealing with advanced forms and the possible consequences. Particularly relevant for neurosyphilis high mortality. The problem of syphilis has not lost its relevance now. This is facilitated by low social and economic development, military events. Besides increasing the number of cases with atypical course. The article described the case of clinical practice - diagnosis and treatment tactics of patients diagnosed with neurosyphilis.
Assessment of the severity of cognitive disorders based on cerebral hemodynamics in patients with stable angina
Authors: Inhula N.
Published: February 2019

Cerebrovascular disease is a leading cause of death and disability in the world's population. The structure of these diseases occupies about 90% of chronic cerebral ischemia (CCI). Concomitant cardiac dysfunction disorder increases cerebral blood flow, leading to disruption of compensatory possibilities cerebrovascular system and the development of acute cerebrovascular events. It examined 21 patients aged (average age – 62.2 ± 7.9 years) with CCI and stable angina (SA) FC II and III. By age and sex of the two groups were equivalent. For patients with combined cerebral and cardiac pathology is a characteristic change in systemic hemodynamics mainly hypokinetic type. The data neuropsychological tests indicate more pronounced cognitive deficits in patients with CCI against the background SA FC III, shown a decrease in memory, attention, perception and orientation than in patients on background SA II FC.
Metabolic correction of chronic brain ischemia in patients with diabetes using the drug сytoflavin
Authors: Svyrydova N. , Zamolotova K. , Bytsay Т.
Published: February 2019

The results of the analysis of the effectiveness of the drug cytoflavin having cytoprotective, and anti-hypoxic metabolic action. It is proved that the timely use of the drug in developing cytoflavin dіsmetabolic encephalopathy in patients with type 2 diabetes (compared to conventional therapy), metabolic correction contributed to the development of chronic brain ischemia, given the significant (p <0.01) hypoglycemic effect.
Syndromology lesions of the extrapyramidal system (Translation Section «Clinical Neurology», 4th Edition (2014), T.J. Fowler,John W. Scadding,Nick Losseff, J.W.Scadding)
Authors: Kucheieva I.
Published: February 2019

The term “movement disorders” has come to be applied to those diseases of the nervous system, mostly of the basal ganglia, which cause disturbances of movement which cannot be attributed to sensory loss, weakness or spasticity, or obvious cerebellar ataxia.
Features of the relationship between blood pressure and endothelial vasomotor function of the initial manifestations of chronic brain ischemia patients
Authors: Treschinskaya M.A. , Golovchenko Y.I. , Ryabichenko T.M. , Klyuchnikova O.A. , Belska I.V. , Kurochkin I.V.
Published: February 2019

Introduction. Cerebrovascular pathology in all its manifestations (acute ischemic stroke and chronic cerebral ischemia) leads to significant mortality and disability in the population in our country. Arterial hypertension (AH) is one of the main factors of cardiovascular risk of chronic cerebral ischemia (ChCI). We carried out a study whose purpose was to assess the state density and the nature of relationships between indicators AP monitoring (DAPM) and biochemical indices of endothelial vasomotor function in patients with initial manifestations of ChCI.

Material and methods. We examined 116 patients with initial manifestations of ChCI. All patients underwent general-clinical, clinical and neurological, neuroimaging, clinical and laboratory examination, including the determination of biochemical markers of vasomotor endothelial dysfunction (endothelin-1 (ET-1) and nitrite) and compression test to assess flow-mediated dilation (FMD).

Results and its discussion. Percentage (FMD obtained during cuff trials statistically significantly correlated with mean PAT day (r = -0,306, p = 0,002) and an average PAP night (r = -0,327, p = 0,001). Tight linkage was observed between the level of ET-1 and indicators of blood pressure variability, thus mainly at night (SBP, DBP, ABP, PBP). The level of nitrite was mainly associated with blood pressure load index. A sufficiently high density of association (by Cramer's V=0,419-0,566) points to the clinical significance of the relative risk of rejection nitrite levels beyond the norms (the development of endothelial dysfunction) by increasing the load systolic and diastolic blood pressure and systolic blood pressure during the day at night.

Conclusions. It was found that the increase in PAP in active and passive during the day has been associated with the development of vasomotor ED. It was found that increased levels of ET-1 was accompanied by an increase in the variability of systolic blood pressure during the day and at night, diastolic blood pressure, SBP and DBP at night. There was a trend to an increase in systolic blood pressure load due to lower levels of nitrite. Sufficient density of associative links point to the trend towards the development of vasomotor ED with increasing load systolic blood pressure during the day and at night.
Аnalysis of risk factors in patients with multiple sclerosis in terms of comorbidity
Authors: Chupryna G. , Svyrydova N. , Galusha A.
Published: February 2019

Were analyzed risk factors (RF) in patients with multiple sclerosis (MS) in the aspect of comorbidity. It was systematized and analyzed anamnestic RF and the development of MS. It is shown that multifactorial pathological effects is most important as a factor of development of the disease, exacerbation and progression in MS. Along with such traditional RF of MS, as a viral infection, psycho-emotional stress, and childbirth, the development of disease exacerbation and progression in MS also have an important role such RF as sleep disturbances, exacerbation of visceral disease and exacerbation of pain.
Clinical and instrumental indices and features of risk factors for patients with recurrent ischemic stroke
Authors: Mykytei O.
Published: February 2019

The aim of the study was to improve the diagnostic approach in patients with re-ischemic stroke based on the analysis of risk factors for the dynamics of neurological deficiency, taking into account clinical and instrumental indices. We were examined 124 patients, of which 94 patients with ischemic stroke in acute period, which arrived in the hospital for up to 2 days after the onset of the disease and were observed in the neurological department. The control group consisted of 30 patients with hypertensive encephalopathy. The analysis of the indicators of daily blood pressure monitoring, duplex scan of vessels of the head and neck in patients with repetitive ischemic stroke indicates a progressive course of stroke, changes in the elastic properties of the vascular wall of the major arter- ies, and a decrease in their speed indicators, which leads to progression of the decrease in the volume of cerebral blood flow Brain of patients. The conducted research allowed to improve the efficiency of diagnostics of the development of repeat ischemic stroke by studying the features of central and cerebral hemodynamics.
Rehabilitation of patients suffering from ischemic stroke by methods of ozonotherapy, kinesitherapy, physiotherapy and acupuncture
Authors: Dovgiy I. , Svyrydova N.
Published: February 2019

The results of the study of the effectiveness of the method of ozonotherapy and acupuncture in the complex treatment of patients suffering from ischemic stroke are shown in the work. The research of the analysis of the results of rehabilitation treatment for 125 patients who suffered from ischemic stroke was evaluated by clinical parameters at 1 day and 21 days after treatment.During the treatment, there was a significant (p<0.05) positive dynamics of the subjective state of patients: they complained about the headache of 18 patients (14.4%), dizziness – 38 patients (29.6%), head noise, ears – 57 patients (46,4%), with sleep disorders – 8 patients (6,4%). We received a significant (p <0,05) decrease in the severity of the neurological deficiency (11,50±0,36); Self-service indicators according to the Bartel index (84.2 ±4.3); Indicators of the level of de- pression on the Hamilton scale (14,81±1,05), indica- tors of evaluation of cognitive dysfunction by break- down with 10 words (74,8±4,23). Significant positive changes (p <0,05) occurred in the psycho-emotional sphere: decreased affectivity, improved mood, memory, thinking, normalized sleep, reduced general weakness, and motivation for recovery. It is proved that an effective measure of complications of ischemic stroke is the correction by means of complex treat- ment (medical and medical methods) and the revealed factors of the risk of disease development. Application of ozonotherapy in combination with reflexotherapy (acupuncture), as well as kinesitherapy and physi- otherapy showed a significant (p <0,05) high efficacy in the treatment of patients with ischemic stroke.
Use of L- arginine in the treatment of comorbid pathology in neurological patients
Authors: Svyrydova N. , Zhhilova N.
Published: February 2019

Amino acids are the structural chemical units that make up proteins. The special importance of amino acids is that some of them - precursors of neurotransmitters which are necessary for normal functioning of the brain. The absence one of  essential amino acid suspend the formation of protein. Correction of deficiency of essential amino acids and replacement carried out by different drugs. Recently, interest in preparations that contain arginine significantly increased. This interest caused by the importance of L- arginine in the body functioning, as L- Arginine is a precursor of nitric oxide (NO). Arginine (Valagyn) is a common post-translational modification of proteins tsytoplazmatycheskyh that has a unique transcriptional regulatory pathways. L-arginine showed a protective effect in ischemia / reperfusion injury, which can be widely used in various diseases of the cardio-sudinnoyi system and metabolic disorders
Comparative analysis of daily blood pressure profile in patients with recurrent and primary ischemic stroke
Authors: Svyrydova N. , Mykytei O.
Published: February 2019

To conduct a comparative analysis of daily blood pressure profile in patients with recurrent and primary ischemic stroke. We were examined 124 patients, of which 94 patients with ischemic stroke in acute period, which came to the hospital in up to 2 days after the onset of the disease and were observed in the neurological department. The control group consisted of 30 patients with hypertensive encephalopathy. The conducted analysis of daily blood pressure monitoring in patients with recurrent and primary ischemic stroke indicates the importance of using this diagnostic method as a reliable difference in many indicators of arterial pressure is obtained. The difference averages of daily monitoring of blood pressure for all periods day informative confirms the difference in blood pressure in patients with primary and repeated ischemic stroke, as observed significant difference of values: the day indices of systolic, diastolic, blood pressure pulse heart rate parameters. The study allowed to increase the effectiveness of the diagnosis of recurrent ischemic stroke by studying the characteristics of central hemodynamics.
Investigation of the autonomic nervous system in patients with chronic heart failure and chronic cerebral ischemia
Authors: Zhhilova N.
Published: February 2019

The number of scientific studies which proving that the cause of many chronic diseases is the autonomic nervous system dysfunction has increased. The changes in the autonomic nervous system can be detected before the appearance of clinical symptoms. This is the basis of prevention. Reducing the influence of the parasympathetic nervous system and activating the sympathetic nervous system are predictors of arterial hypertension, cardiovascular diseases, diabetes and others. There are no clear mechanisms for the emergence of hyperactivity of the sympathetic nervous system in cardiovascular pathology. That is why it needs to be studied. And that is why the study of the influence of the autonomic nervous system in chronic conditions is relevant.
Relationship between the state coagulation system, protein and fat metabolism, and Brain iron deposition in patients with cerebral small vessel disease
Authors: Petrenko M.
Published: February 2019

Brain iron deposition correlates with clinical manifestations of cerebral small vessel disease. Excessive iron load leads to the formation of free radicals, and nervous tissue damage. The main damaging effect of hydroxyl radicals is due to conversion of soluble fibrinogen to insoluble fibrin. There is also a possible relationship between the functional state of the liver and the early manifestations of cardiovascular disease. Objective: to investigate the relationship between the parameters of coagulation system, liver functional state, fat and protein metabolism, and brain iron deposition in patients with cerebral small vessel disease in the presence of hypertension and cerebral atherosclerosis. Materials and methods: 80 patients with diagnosed cerebral small vessel disease were selected. Patients were divided into two groups, depending on the severity of brain iron deposition. All patients underwent MRI in the T1-WI, T2-WI, TIRM, DWI, and SWI sequences. Determination of the coagulation system parameters and the biochemical analysis were carried out during routine blood test. Results: using a double-sample t test, it was determined that patients with severe brain iron deposition had higher levels of urea, triglycerides, and prolonged thrombin time. With the logistic regression analysis adjusted by the age and sex, levels of urea and the length of thrombin time were determined as the independent risk factors for severe brain iron deposition. For urea OR 1.87, CI 95% 1.31-2.65 (p = 0.02), for thrombin time OR 1.55, CI 95% 1.06-2.26 (p = 0.02). For these parameters, the risk increased when assessing only patients with ALT levels> 15 U / l. For such patients, the relationship between thrombin time and brain iron deposition increased significantly: OR 2.11, CI 95% 1.20-3.71 (p = 0.01). In this study no relationship was found between the indicators of fat metabolism, levels of fibrin and iron deposition. There is a probable relationship between the brain iron deposition and the state of coagulation system, protein metabolism and liver functional state in patients with cerebral small vessel disease.
The analysis of comparative characteristics of assessment of psychoemotional status and vegetative resistance in patients with chronic cerebral ischemia on the background of angina pectoris
Authors: Inhula N.
Published: February 2019

The analysis of comparative characteristics of assessment of psychoemotional status and vegetative resistance in patients with chronic cerebral ischemia on the background of angina pectoris: 90 subjects (61 men and 29 women) (mean age 60.6 ± 7.8 years) were examined in the main group and 30 persons (10 men and 20 women) (mean age 55.27 ± 5.5 years) control group aged 45 to 74 years. The was found that a high level of anxiety causes an imbalance between sympathetic and parasympathetic activity. In the group of patients with CCI against the background of stable angina pectoris III FС revealed a high level of depression and anxiety, reactive and personal anxiety, which causes a pronounced autonomic dysfunction, which was manifested in insufficient vegetative provision and the predominance of sympathicotonia in these patients.
Lecture of the cycle of specialization in reflexology "Practical application of the theory of U-Sin in traditional Chinese medicine"
Authors: Chuprina G. , Parnikoza T. , Svyrydova N.
Published: February 2019

The theory of the five elements is widely used in traditional Chinese medicine, and the division of natural phenomena according to the properties of the five elements and the nature of the relationship between them, is practical in clinical acupuncture: to characterize the structural, physiological and pathological features of the patient, diagnosis and treatment. With the development of diseases there is a pathological relationship between Zhang-Fu organs and tissues that they are subordinated to. The human body is an organic whole, in which there are numerous interconnections in the development of the pathological process due to the existing modified interconnections. It is established that the theory of five elements is a simple theory with certain limitations. The laws of the relationship between the elements of the U-Syin cycle are not a reflection of all possible interconnections between the Zhang-Fu organs and the related tissues. In clinical practice, these laws show objective physiological and pathological communications between the internal organs and can be used in the process of acupuncture diagnosis and treatment. The theory of the five elements lies at the heart of the methodology of traditional acupuncture diagnostics, used during its implementation and data analysis, it determines the pathological states in accordance with the characteristics and laws of the relationship of the five elements and formulates the syndromic diagnosis of traditional Chinese Medicine (TCM).
Analysis of the connection of the concentration of iron in basal nuclei with cognitive impairments in patients with hypertension and atherosclerotic encephalopathy in the study of changes in the magnetic susceptibility of the subcortical structures of the
Authors: Petrenko M. , Grabovetskii S.
Published: February 2019

Vascular diseases of the brain are an important medical and social problem that negatively affects the economy of the country and the life of society as a whole. Discirculatory encephalopathy refers to slowly progressing disorders of the cerebral circulation, in which development of an essential role is played by hypertension, atherosclerosis, diabetes mellitus and other diseases that affect the vessels of the brain. The purpose of the study was to identify a specific pattern of iron accumulation in the subcortical structures of the brain of hypertensive and atherosclerotic encephalopathy patients to improve the diagnostic criteria for the development of cognitive impairment. For the study, 20 patients in the main group with a diagnosis of hypertensive and atherosclerotic encephalopathy were selected, and the control group consisted of 20 patients, the results of which neuropsychiatric tests were within the normal range. According to the results of the study, the accumulation of iron in the basal ganglia is higher in patients with the main group compared with the control group. The exact mechanism for increasing the concentration of iron in the basal ganglia of the patients in the main group is not known, but this study confirms that deposition of subcutaneous iron may be used as a biomarker for early diagnosis of vascular dementia that develops against the background of hypertensive and atherosclerotic encephalopathy. The results of the study reliably established the existence of a negative correlation between hypointensity of subcortical nuclei and neuropsychological parameters in patients with the main group.
PROGRAM PROMOSI KESEHATAN REPRODUKSI DAN SEKSUAL BAGI REMAJA: ARTICLE REVIEW
Authors: Panjaitan Arip Ambulan , Nugraheni Sri Achadi
Published: February 2019

Latar Belakang: Remaja memiliki beban tinggi masalah kesehatan seksual dan reproduksi dan penting untuk menjangkau kelompok remaja melalui inisiatif promosi kesehatan. Dilakukan tinjauan pustaka untuk mengidentifikasi unsur-unsur program promosi kesehatan yang berhasil untuk meningkatkan kesehatan reproduksi dan seksual remaja.Metode: Penelitian ini mengidentifikasi dan menyusun tinjauan pustaka yang diterbitkan pada tahun 2000-2018 yang berfokus pada remaja (10-24 tahun), melaporkan hasil kesehatan reproduksi dan seksual (kehamilan, infeksi menular seksual, kondom/penggunaan kontrasepsi, perilaku seksual berisiko, akses perawatan kesehatan seksual atau intim kekerasan mitra), dan termasuk studi utama yang terutama dilakukan di negara-negara berpenghasilan tinggi. Laporan ini berfokus pada fitur-fitur program kesehatan reproduksi dan seksual yang berhasil diidentifikasi dalam interpretasi dan diskusi ulasan sistematis yang disertakan.Hasil: Penelitian ini mengidentifikasi 66 tinjauan sistematis, yang 37 dilaporkan pada program yang secara anekdot atau terkait secara statistik dengan peningkatan efektivitas dan keberhasilan program. Ciri-ciri umum intervensi yang efektif adalah: penerapan jangka panjang atau berulang; multi-pengaturan dan multi-komponen; keterlibatan orang tua; sesuai dengan budaya, jenis kelamin, usia; dan dimasukkannya pembangunan keterampilan.Kesimpulan: Ada konsistensi ditandai fitur meningkatkan efektivitas program kesehatan reproduksi dan seksual untuk orang-remaja meskipun variasi luas dalam intervensi ditinjau. Ada kebutuhan untuk mengimplementasikan pengetahuan ini dengan lebih baik di program mendatang, dan temuan kami memberikan panduan yang berguna untuk mengoptimalkan rancangan intervensi kesehatan reproduksi dan seksual untuk remaja.
DETERMINAN KESEHATAN PADA ANAK SEKOLAH DENGAN INTERVENSI BERBASIS SEKOLAH : A LITERATUR REVIEW
Authors: Triwahyuningsih Ria Yulianti , Nugraheni Sri Achadi
Published: February 2019

Sekolah mempunyai peran penting dalam promosi kesehatan terutama dengan meningkatkan pengetahuan, perilaku dan prestasi akademik siswa (1). Promosi kesehatan berbasis sekolah dapat sangat berharga di negara berkembang maupun negara maju yang menghadapi tantangan teknologi informasi kesehatan yang rendah dan infeksi penyakit (2,3), atas literatur yang diterbitkan berfokus pada sekolah berbasis intervensi untuk promosi kesehatan dan mereka berdampak di suatu negara (2). Penulis termasuk 50 penelitian yang memenuhi kriteria khusus: (i) studi terutama anak-anak sekolah atau remaja yang ditargetkan; (ii) desain yang diterima secara acak uji coba terkontrol, studi terkontrol sebelum-sesudah atau seri waktu terputus; (iii) studi disertakan setidaknya satu ukuran dampak dan (iv) adalah studi utama atau tinjauan sistematis dan obsevasional (4). Penulis menemukan bahwa intervensi berbasis sekolah dapat diklasifikasikan dalam dua kategori utama: mereka yang menargetkan individu faktor penentu kesehatan seperti pengetahuan, keterampilan dan perilaku kesehatan(5) dan mereka menargetkan faktor penentu lingkungan seperti sosial dan lingkungan fisik di sekolah, keluarga dan tingkat komunitas(6). Temuan menunjukkan bahwa pendekatan komprehensif yang menangani individu dan faktor penentu lingkungan dapat menginduksi perubahan perilaku jangka panjang dan secara signifikan meningkatkan hasil kesehatan dan pendidikan intervensi yang berkaitan dengan informasi tekhnologi baik app mobile atau media sosial (7). Kami menyoroti kebutuhan untuk studi lebih lanjut dari jangka panjang dampak intervensi berbasis sekolah pada kesehatan hasil di suatu negara
‘Rimbaud in Embryo’: Collaborative Reproduction in T. S. Eliot and Hart Crane
Authors: Cotton Jess
Published: February 2019

The reproductive metaphors that T. S. Eliot uses in his early theories of creativity are indicative of modernism's ambivalence towards collaborative authorship. Moving away from a critical tendency to read Eliot's collaborative practice primarily in terms of Pound's editorial signature, this article examines how modernist collaboration, as theorised by Eliot, is bound up with a fantasy of origins. Framed by Eliot's positing of ‘merging’ as ‘involuntary collaboration’, it considers the collapse that occurs between co-labour, imitation, and theft not only in Eliot's work but also that of Hart Crane. More particularly, the article explores how Eliot and Crane both make use of another poet's work to release their own poetic sensibilities; it also shows how ‘involuntary collaboration’ takes on a shadowy presence in their respective works. This highlights the complex role that fantasy and affect play within modernist poetry's collaborative practices and attempts to forge a poetic community.
Dylan Thomas's ‘Return Journey to Swansea’: A Collaborative Radio Poetic
Authors: Williams Nerys
Published: February 2019

This article explores how Dylan Thomas's engagement with radio created an innovative collaborative radio poetic. Thomas contributed many broadcast essays and features to the Third Programme, the Home Service, the Welsh Home Service and the Eastern Service. Scholars have also long been aware of Thomas's important creative relationship with BBC producers such as Douglas Cleverdon (who produced Under Milk Wood). Yet there remains little analysis of his features for radio. Drawing on archival memos from the BBC's Literary Output Committee (held at the BBC's Written Archives in Caversham), this article initially considers the institutional relationship between poets and the BBC during the 1940s. Against this institutional backdrop, it then focuses on a specific 1947 BBC feature that Thomas wrote about post-blitz Swansea: ‘Return Journey to Swansea’. Examining the history and practicalities of the collaboration involved between Thomas and the producer P. H. Burton, the discussion links the feature's social commentary to the audio radio poetic collaboratively created between poet, broadcast institution, producer, and medium.
Laura (Riding) Jackson's ‘co-operative hostility’
Authors: Bailey Iain
Published: February 2019

Laura (Riding) Jackson's early collaborations with Robert Graves are well known, as is her renunciation of poetry to embark on a lifelong linguistic project with her second husband, Schuyler B. Jackson. The centrality of collaboration to her theory of language has not, however, been properly expounded. In the later work, especially, she puts forward a notion of intense collective effort in which personalities are to be changed through labour on words and meaning. Collaboration is both the means and the ends of an improved understanding of language and its potential. Critics and biographers have pointed to the ways in which her collaborations tended to involve conflicts of authority, and she is often charged with a desire to dominate. Focusing too much on personality, however, misses the more fundamental contradictions of her work. This paper argues that (Riding) Jackson's gendered notion of ‘co-operative hostility’ offers a sharp critique of masculine domination, cultural capital, and appropriation, as well as a speculative notion of social transformation based on mutual exploration and use. These elements of her work run into conflict, however, with her explicit and absolute commitment to private property.
Local knowledge, local learning and predicting election outcomes: voter assessments of likely party success in Scotland's constituencies at the 2015 and 2017 general elections
Authors: Johnston Ron , Pattie Charles , Hartman Todd K.
Published: February 2019

Political scientists often debate how much information people have and deploy when making electoral decisions. Some scholars suggest that voters are aware of which party is likely to win in their local constituency at British general elections; however, this might not be the case in situations when there is substantial and spatially varying change in the relative fortunes of two or more parties between elections. That argument is evaluated here using as a case study the 2015 and 2017 general elections in Scotland: at the first, the SNP's vote share more than doubled, and it won 56 of the country's 59 seats, having won just six at the previous contest; at the second, its vote share fell by about a third, and it lost 21 of those 56 seats. Analysis of British Election Survey data collected before and during the campaigns preceding those elections shows that most respondents were aware of the SNP's surge in 2015 and expected their victory in every constituency. In 2017, most voters were aware which of the SNP's three competitors was the biggest threat in each constituency, and that awareness became clearer during the campaign; yet, voters – especially those who identified with the SNP and were contacted by it during the campaign – still (incorrectly) anticipated a local SNP victory.
‘Churchill rolled the tanks into the crowd’: mythology and reality in the military deployment to Glasgow in 1919
Authors: Barclay Gordon J.
Published: February 2019

The ‘Battle of George Square’, 31 January 1919, is perhaps the most mythologised event in 20th-century Scottish history. A demonstration in support of the 40-hours strike descended into a violent riot and the Sheriff of Lanarkshire read the Riot Act and called in military aid, which he had already made sure would be available. Ten thousand, mainly Scottish, troops arrived that night in a city that was already returning to peace, followed three days later by six tanks. A largely mythological version of events has dominated Scottish popular history during the last century and the mythology has more recently developed beyond a narrative of ‘capitalist oppression’ to include one of ‘English oppression’, the deployment of ‘English troops’, by an ‘English government’, ‘sent by Churchill’. This paper attempts to document the formation of the different elements of the mythology (while briefly explain why they are myths), how they have developed and been used in popular history and more recently, in political discourse on social media.
Synthesis of C3-symmetric star-shaped molecules containing α-amino acids and dipeptides via Negishi coupling as a key step
Authors: Kotha Sambasivarao , Todeti Saidulu
Published: February 2019

We demonstrate a new synthetic strategy toward star-shaped C3-symmetric molecules containing α-amino acid (AAA) derivatives and dipeptides. In this regard, trimerization and Negishi cross-coupling reactions are used as the key steps starting from readily available 4’-iodoacetophenone and L-serine. These C3-symmetric molecules containing AAA moieties are useful to design new ligands suitable for asymmetric synthesis and peptide dendrimers.
Systematic Structure and Sinks in the YORP Effect
Authors: Golubov Oleksiy , Scheeres Daniel J.
Published: February 2019

There is a correlation between the components of the YORP effect of most asteroids, which drives the obliquity and spin rate of the affected bodies in a consistent pattern. This allows for a clear and unambiguous picture for how the spin rates and poles of asteroids affected by YORP will evolve and simplifies the overall picture for how populations will migrate on average. The YORP effect can also lead to a previously unexplored equilibrium state for affected bodies. This equilibrium state is a function of the usual normal YORP effect (which arises due to the global shape asymmetry of the asteroid) and the tangential YORP effect (which arises due the transport of thermal energy through rocky surface features). Estimates from current shape models show that 10%–20% of asteroids have the proper condition to be captured in this equilibrium state, indicating that the occurrence of this state may be significant. The existence of this attractor for the asteroid population means that objects affected by YORP may leave their usual YORP cycles and maintain a constant spin rate over long time periods—this has significant implications for our interpretation of asteroid spin rate evolution and related theories for their physical evolution.
The Aemulus Project. II. Emulating the Halo Mass Function
Authors: McClintock Thomas , Rozo Eduardo , Becker Matthew R. , DeRose Joseph , Mao Yao-Yuan , McLaughlin Sean , Tinker Jeremy L. , Wechsler Risa H. , Zhai Zhongxu
Published: February 2019

Existing models for the dependence of the halo mass function on cosmological parameters will become a limiting source of systematic uncertainty for cluster cosmology in the near future. We present a halo mass function emulator and demonstrate improved accuracy relative to state-of-the-art analytic models. In this work, mass is defined using an overdensity criteria of 200 relative to the mean background density. Our emulator is constructed from the Aemulus simulations, a suite of 40 N-body simulations with snapshots from z = 3 to z = 0. These simulations cover the flat wCDM parameter space allowed by recent cosmic microwave background, baryon acoustic oscillation and SNe Ia results, varying the parameters w, Ω
m
, Ω
b
, σ
8, N
eff, n

s
, and H
0. We validate our emulator using five realizations of seven different cosmologies, for a total of 35 test simulations. These test simulations were not used in constructing the emulator, and were run with fully independent initial conditions. We use our test simulations to characterize the modeling uncertainty of the emulator, and introduce a novel way of marginalizing over the associated systematic uncertainty. We confirm nonuniversality in our halo mass function emulator as a function of both cosmological parameters and redshift. Our emulator achieves better than 1% precision over much of the relevant parameter space, and we demonstrate that the systematic uncertainty in our emulator will remain a negligible source of error for cluster abundance studies through at least the LSST Year 1 data set.
On the Background-gyroresonant Character of Bell’s Instability in the Large-current Regime
Authors: Weidl Martin S. , Winske Dan , Niemann Christoph
Published: February 2019

We show that the Bell instability, which is widely considered potentially important for cosmic-ray (CR) acceleration, is the low-frequency limit of a gyroresonant interaction between the protons of the interstellar medium and shear-Alfvén waves. At large CR current densities, its growth rate is therefore limited by the proton gyrofrequency, and two modes emerge from the cold-beam dispersion relation. A third mode driven by electron gyroresonance is only weakly unstable at low current densities. We discuss implications for magnetic field amplification and its saturation in the vicinity of supernova remnants.
Revisiting the Galaxy Shape and Spin Alignments with the Large-scale Tidal Field: An Effective Practical Model
Authors: Lee Jounghun
Published: February 2019

An effective practical model with two characteristic parameters is presented to describe both the tidally induced shape and spin alignments of galactic halos with large-scale tidal fields. We test this model against the numerical results obtained from the Small MultiDark Planck simulation on the galactic mass scale of

at redshift z = 0. Determining empirically the parameters from the numerical data, we demonstrate how successfully our model describes simultaneously and consistently the amplitudes and behaviors of the probability density functions of three coordinates of the shape and spin vectors in the principal frame of the large-scale tidal field. Dividing the samples of the galactic halos into multiple subsamples in four different mass ranges and four different types of the cosmic web, and also varying the smoothing scale of the tidal field from 5 h
−1 Mpc to

Mpc, we repeatedly perform the numerical tests with each subsample at each scale. Our model is found to match well the numerical results for all of the cases of mass range, smoothing scale, and web type and to properly capture the scale and web dependence of the spin-flip phenomenon.