bluuebunny/crossref_metadata_2025 huggingface dataset:
Unravelling Potential Mechanisms of Piper retrofractum Vahl. Bioactive Compounds as Cervical Cancer Chemopreventive Agent by Bioinformatic Approach
Authors: Mahindra I Kadek Sindhu Satya , Kusuma I Made Gede Ari , Sari Wayan Dianda , Diantari Desak Made Dewi , Lestari Priyanka , Santika I Wayan Martadi
Published: August 2024

Cervical cancer is the leading cause of cancer death after breast cancer. HPV infection is the main cause of cervical cancer which will cause overexpression of E6 oncoprotein. E6 oncogene can cause cancer cells to continue to proliferate. Long pepper fruit (Piper retrofractum Vahl.) has antioxidant activity and contains piperine compounds that have anticancer activity. This study aims to assess the potential of long pepper fruit extract as a chemopreventive agent for cervical cancer. The research method was conducted by in silico assay with network pharmacology and molecular docking analysis. We found five hub genes including HSP90AA1, SRC, AKT1, STAT3, and PIK3CA. KEGG analysis showed that the most dominant signaling pathways involved are neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, MAPK signaling pathway, Calcium signaling pathway, and cAMP signaling pathway. Through molecular docking, it was found that long pepper fruit has the potential to inhibit the E6 oncogene of HPV. Based on the research results, long pepper fruit extract may has the potential as a chemoprevention agent for cervical cancer.Keywords: Cervical cancer, oncoprotein HPV16-E6, Piper retrofractum Vahl., molecular docking, network pharmacology.
In the Shade of Hailstones: Life-Forming Realities among the Luo of Kano, Kenya
Authors: Opande Kennedy , Onyango-Ouma Washington
Published: August 2024

In the area of Kano in western Kenya, Luo rice farmers perform a ritual of “digging” indigenous medicine (chwoyo yath) in the rice fields to “arrest” hailstones. The practice is not only rationalized in the image of regulating the spate of climate–accelerated hailstones but also of forming life, expressed through the state of how that life is secured and propagated. Drawing on ethnographic interviews with rice farmers and an expert on hailstones, as well as on participant observation, this article explores the exegetical agency of rice medicines, which is reflected in the affective act of arresting hailstones. This is conceptualized through a cosmo–juridical agency of life-forming by creating an interconnection between human life and a natural phenomenon. The article underscores the varied domains of natural phenomena (weather conditions, calamities), rice crop, and humans as agencies that co-negotiate toward life-forming through their forces that transform states of life processes.
KIBRIS’TA İKİ DEVLETLİ ÇÖZÜM ÖNERİSİNİN İNCELENMESİ
Authors: Çimen Ali Said
Published: August 2024

Kıbrıs Cumhuriyeti’nin kurulmasının akabinde Türk ve Rum halkları arasında adada birçok çatışma yaşanmıştır. Bu çatışmaların sebebi Türk toplumuna yönelik hayata geçirilen asimilasyon eylemleri ve Rum egemenliğini hayata geçirmek için yürütülen şiddet eylemleridir. Yaşanan çatışmaları durdurmak için 1974’te hayata geçirilen Barış Harekâtı neticesinde Kıbrıs sorunu farklı bir aşamaya dönüşmüştür. Adada yaşanan sürece Birleşmiş Milletler (BM) de dâhil olarak Genel Sekreterler aracılığıyla birçok çözüm önerileri sunulmuştur. Bu çözüm önerileri federatif devlet esaslı, aynı devlet çatısı altında iki toplumlu düzen çerçevesinde olmuştur. Fakat bu gayretlerin tümü başarısızlıkla neticelenmiştir. Bazen silahlı çatışmalarla bazen de diplomatik ihtilaflarla uzun yıllardır uluslararası sistemin gündeminde yer alan bu probleme artık farklı bir bakış açısıyla yaklaşmanın vakti gelmiştir. Bu çalışmanın amacı günümüze dek teklif edilen çözüm önerilerinin başarısız olması sebebiyle iki devletli çözüm önerisinin başarılı olup olamayacağının değerlendirilmesidir. Böylece yıllardır çözüm bulunamayan soruna alternatif üretilecektir. Sosyal bilimlerin esas araştırma usullerinden nitel araştırma usulüyle hazırlanan çalışmamızda Kıbrıs Sorunu’nun taraflarının sunduğu belgeler, tutanaklar, raporlar ve beyanlar analiz edilecektir.
AKA GÜNDÜZ’ÜN HİKÂYELERİNDE KADIN
Authors: Çopur Yusuf
Published: August 2024

1884’te dünyaya gelen Aka Gündüz, romandan hikâyeye, tiyatrodan şiire pek çok türde eserler vermiştir. Yazar, içinde yaşadığı toplumun tarihi dönemeçlerine şahitlik etmiş, eserlerinde bu sosyal değişimlere sıklıkla yer vermiştir. Gündüz’ün ilk dönem hikâyelerinde (1909-1914) milli şuur teması ağırlıktadır. Yazarın ikinci dönem (1914-1923) öyküleri bu zamanı kapsar. Gündüz’ün Anadolu’yu konu alan öykülerinde mizahi bir anlatım vardır. Yazar, Anadolu’daki günlük yaşamı, sosyal meseleleri, ekonomik sorunları öykülerinde ele alır. Aka Gündüz’ün öykücülüğündeki üçüncü dönem olan Cumhuriyet sonrası (1923-1949) öykülerindeyse toplumsal konular ağırlıktadır. Aile, kadın, çocuk ve eğitim yazarın bu dönem en sık işlediği konulardandır. Aka Gündüz, son dönem öykülerinde toplum ve aile hayatında kadınların yaşadıklarına, onların sosyal sorunlarına, toplumun ahlak anlayışı altında çoğu zaman ezilmelerine değinir.
Green synthesis of zinc oxide nanoparticles using Terminalia arjuna bark extract: structural, optical and photocatalytic study
Authors: Saha Suvankar , Mochahari Prince Kumar
Published: August 2024

Zinc oxide (ZnO) nanoparticles have been successfully synthesized by using Terminalia arjuna bark extract via a green route. Structural analysis using X-ray diffraction confirmed the prepared samples are crystalline having hexagonal wurtzite structure with space group P63
mc and average crystallite size is found to be 8.93 nm. Rietveld refinement of the data was carried out using Material Analysis Using Diffraction (MAUD) software and reliability parameters of the refinement have been obtained. Optical properties of the sample investigated by ultraviolet – visible diffuse reflectance spectroscopy reveal an absorption peak to lie at 348 nm and the direct optical band gap energy using Kubelka–Munk function is found to be 3.20 eV. Morphological investigation using scanning electron microscopy revealed that ZnO nanoparticles are nearly spherical and agglomerated. Energy-dispersive X-ray spectrometry analysis showed the presence of Zn and O only. Transmission electron microscopy imaging confirmed the predominant hexagonal structure of the prepared nanoparticles having average particles size of 9.66 nm, which is in agreement with the X-ray diffraction result. Fourier transform infrared spectroscopy was used to identify the functional groups and different vibrational modes present in the sample. The photocatalytic activity of the prepared ZnO nanoparticles was studied using methylene blue (MB) dye under a single wavelength UV light source (λ = 254 nm). The degree of degradation of MB solution was about 56 % within 120 min of illumination to UV light and the degradation reaction follows first order kinetics with rate constant 0.00434 min−1.
Flexible silver nanowire-polymer conductive films for electrophysiological detection
Authors: Liu Benyan
Published: August 2024

This study employed polydimethylsiloxane and silver nanowire (AgNW) to prepare polymer films for electrocardiography and electromyography sensing. Two approaches were employed to prepare AgNW-based polymer films. In the first approach, AgNW was embedded in polydimethylsiloxane through polymer infiltration. In the second approach, AgNW was applied to the surface of the polymer. The fabricated polymer films were effectively employed in electrocardiography and electromyography measurements, revealing efficiency comparable to traditional silver/silver chloride wet electrodes. The presented approaches are inexpensive and suited to mass production and thus hold great promise in the fabrication of polymer electrodes for medical monitoring.
The rise of advanced practice provider independence bills: a misguided attempt to address the physician shortage
Authors: Bohler Forrest , Peters Garrett , Aggarwal Nikhil , Harvey Kyle , Bohler J. David
Published: August 2024

In the past decade, the rise of state legislation that allows for advanced practice provider (APP) independence has grown steadily across the country. Most recently, Montana has enacted House Bill 313, which allows for physician assistant independent practice in primary care services. This is a concerning trend because there is a multitude of studies that demonstrate worsened patient outcomes and increased healthcare expenditures for care delivered by nonphysicians. There are also many unintended consequences that are likely to occur due to this inappropriate expansion of scope of practice for APPs. In this commentary, we outline the ramifications that are likely to occur in states such as Montana that enact legislation that expands the scope of practice for nonphysicians.
Common foot and ankle disorders in pregnancy: the role of diagnostic ultrasound
Authors: Sahr Meghan E. , Grünebaum Amos , Positano Rock C. , Nwawka Ogonna K. , Chervenak Frank A. , Positano Rock G.
Published: August 2024

Foot and ankle disorders are common during pregnancy, driven by significant physiological changes including weight distribution, hormonal fluctuations, and fluid balance. These changes often result in conditions such as varicose veins, thrombophlebitis, deep vein thrombosis (DVT), edema, overpronation, ankle sprains, metatarsalgia, stress fractures, ligament tears, synovitis, tendon tears, tenosynovitis, paratenonitis, plantar fasciitis, and Morton’s neuroma. This paper emphasizes the diagnostic utility of ultrasound for these conditions, given its safety, non-invasiveness, and real-time imaging capabilities without ionizing radiation. Ultrasound is particularly effective for diagnosing venous disorders like varicose veins and thrombophlebitis, leveraging Doppler ultrasound to assess vein structure and function. It is also instrumental in identifying DVT, detecting vein dilation, reflux, and thrombosis. For conditions such as edema, ultrasound helps differentiate physiological from pathological causes, ensuring accurate diagnosis and management. In cases of musculoskeletal issues like overpronation, ankle sprains, ligament tears, and tendon pathologies, ultrasound provides detailed images of soft tissues, allowing for precise diagnosis and effective treatment planning. It is equally useful for detecting metatarsalgia, plantar fasciitis, and Morton’s neuroma, offering insights into soft tissue abnormalities and guiding therapeutic interventions. Ultrasound’s role extends to diagnosing foreign bodies in the foot and ankle, where it demonstrates high sensitivity and specificity. The accessibility and cost-effectiveness of ultrasound make it an invaluable tool in various healthcare settings, ensuring timely and accurate diagnosis and management of foot and ankle disorders during pregnancy, ultimately enhancing patient outcomes and quality of life.
A comparison of recent optimization algorithms for build orientation problems in additive manufacturing
Authors: Günaydın Ahmet Can , Yıldız Ali Rıza
Published: August 2024

Build orientation in additive manufacturing technology is a pre-process application that affects many parameters, such as the volume of the support structure, part quality, build time, and cost. Determining the optimum build orientation for one or more objectives for complex parts is an error-prone puzzle. This study evaluates the behavior of cuckoo search algorithm, differential evolution, firefly algorithm, genetic algorithm, gray wolf optimizer, Harris hawks optimization, jaya algorithm, moth flame optimizer, multi-verse optimizer, particle swarm optimization, A Sine cosine algorithm, salp swarm algorithm, and whale optimization algorithm to determine the optimum build orientation of the component to be manufactured additively. The efficiency of these algorithms is evaluated on the build orientation problem of two complex components considering undercut area and build height as objective functions. Thus, the feasibility of these algorithms for real-world additive manufacturing problems is revealed. According to results obtained from the extensive analysis, the cuckoo search algorithm is the best alternative for minimizing undercut area, considering its robustness. However, the required time to solve the problem is as much as almost twice that of other algorithms. The firefly algorithm and particle swarm optimization algorithm are the best alternatives for minimizing build height.
Rotating bending fatigue behavior of high-pressure diecast AlSi10MgMn alloy based on T5 heat treatment parameters
Authors: Gülmez Cemil Çağrı , Çivi Can , Eyici Gökhan
Published: August 2024

The study investigates fatigue failure, a common phenomenon in machine elements subjected to cyclic stresses. The analysis emphasizes that the actual stress experienced by materials often falls below their tensile and yield strengths due to repetitive variable stresses, leading to fatigue damage. Fatigue life is measured by the number of cycles endured before failure. This paper focuses on the aluminum alloy of AlSi10MgMn, extensively used in manufacturing due to its strength, low density, and corrosion resistance. Experimental procedures encompassed tensile testing, microstructural examination, SEM analysis, and fatigue testing. Tensile tests provided initial stress values for fatigue testing. Microstructure analyses verified that heat-treated samples exhibited precipitates. SEM analysis disclosed microstructural characteristics, while fracture surface examinations demonstrated higher fatigue resistance in heat-treated specimens. Hardness measurements were conducted, with heat-treated samples showing higher values. Theoretical calculations based on stress and cycle numbers were compared to experimental fatigue results. The derived equations aligned well with the tests. Ultimately, the study underlines the importance of heat treatment on material behavior and fatigue resistance, shedding light on alloy performance and durability enhancement.
Capacitive voltage effect at a resistive sintering system container and its electrical model
Authors: Yener Suayb Cagri , Mutlu Resat , Yener Tuba , Akbulut Hatem
Published: August 2024

The electric current activated/assisted sintering (ECAS) method enables various kinds of materials to be produced much faster and environmentally friendly compared to conventional sample production systems. The main handicap of this system is that the heating regime varies according to the material type even the chemical composition of the same type of material and causes partial melting due to the sudden current flow. Previously, the ECAS output equivalent circuit is modeled as a temperature-dependent resistor in the literature. This study shows that it is insufficient to model the ECAS output consisting of a container and two stiffs as a resistor considering experimental waveforms. We report the discovery of a capacitive effect at the output of the ECAS system that has not been reported before. We have given an equivalent electrical circuit for the ECAS system output and examined the effect’s temperature dependence. The circuit model, which consists of a parallel resistor-capacitor (R
p-C) circuit in series with another resistor (R
s), is suggested for the container and the stiffs. By using the experimental data, the equivalent circuit parameters are calculated by curve-fitting. The temperature dependence of the equivalent circuit parameters is also examined. Possible explanations for the capacitive effect are given. Such a model and further examining the effect may help design better ECAS systems.
Tensile testing of S690QL1 HSS welded joint heterogeneous zones using small scale specimens and indentation methods
Authors: Tomerlin Damir , Kozak Dražan , Gubeljak Nenad , Pentek Ivan
Published: August 2024

The welded joints are structures with significant heterogeneity, indicated by their fundamental segmentation into base metal (BM), heat affected zone (HAZ), and weld metal (WM). The heat affected zone, having width in millimeter scale for fusion welding processes, is further segmented into several characteristic regions, having differences in grain structure and size. The microstructural heterogeneity results in significant differences in mechanical properties of individual welded joint zones. Mechanical testing of such small material volumes is inconvenient, or even impossible, using the standard size specimens proposed in testing standards. Requirement to precisely position the specimens, even ones with subsize dimensions, and investigate mechanical properties of specific narrow HAZ regions presents certain challenge. This work investigates the X welded joint of S690QL1 grade high strength steel (HSS), welded with slightly overmatching filler metal. The material tensile properties are tested, using small scale specimens and indentation methods. Small scale specimens are ASTM E8 round tensile subsize and flat sheet mini tensile specimens (MTS). The indentation methods include hardness testing and profilometry-based indentation plastometry (PIP) method, to gain additional insights into material stress–strain behavior. Finally, paper evaluates the testing methods, comparatively processes the collected experimental data, and provides guidelines for heterogeneous structures testing.
Evaluation of oxygen delignified fibers with high water absorbency, as a greener alternative to fully bleached fibers for tissue paper
Authors: Esteves Cláudia V.G.
Published: August 2024

The potential of oxygen delignified fibers to replace fully bleached fibers in tissue products was investigated on softwood pulps. The absorption, mechanical properties and softness of laboratory tissue hand sheets from one commercial fully bleached pulp and five unbleached oxygen delignified lab pulps were compared. The pulps with different lignin content and total fiber charge were evaluated with and without PFI refining. The pulps subjected to oxygen delignification resulted in pulps with much higher total fiber charge content that led to higher swelling and higher wet strength when compared to the commercial fully bleached pulp. Some unbleached oxygen delignified pulps showed great potential in the absorption capacity, while others showed a much higher wet tensile strength when compared to the commercial pulp. Compared to the commercial bleached pulp, a similar softness for a higher wet and dry tensile index in the unbleached fibers was observed for the oxygen delignified pulps. Unbleached pulps subjected to an extended oxygen delignification proved to be a suitable alternative to fully bleached pulps in tissue grades, depending on the desired property (absorption or wet strength).
Commensuration and Currency in Plato’s
Phaedo
Authors: Kamtekar Rachana
Published: August 2024

My aim in this paper is to show that Plato’s Phaedo makes an important contribution to the development of ideas about the commensuration in value of heterogeneous items that is needed for practical reasoning and rational choice. Because the passage I focus on, the so-called ‘right exchange’ passage at 69a-c, has not usually been read this way, I motivate the reading by showing how it resolves some puzzles local to the Phaedo concerning the stark contrast Socrates develops between the virtues of philosophers and nonphilosophers, ordinary people who do not pursue wisdom single-mindedly, applying to the latter labels like ‘strange’, ‘unreasonable’, ‘illusory’ and ‘slavish’. Socrates says that one should, and suggests that philosophers do, use wisdom as their currency whereas nonphilosophers use pleasure (and perhaps also pains, fears, etc., or bodily conditions in general) as their currency (or currencies). Although it has been generally understood that the basis for this contrast lies in how the two groups evaluate, the details have remained murky. I argue that it’s due to the properties of pleasure (or bodily conditions in general) qua measure of value, in particular pleasure’s context-dependence, that nonphilosophers’ judgements about virtue, e.g. the courage and moderation of particular acts or people, are defective in the ways Socrates says they are.
On the So-called Focal Analysis of Friendship in
Eudemian Ethics
VII.2
Authors: Watanabe Kunio
Published: August 2024

Aristotle is believed to have introduced the focal meaning of friendship in Eudemian Ethics VII.2 and then to have formulated it more generally in Metaphysics Γ.2. Bonitz’s unjustifiable emendation of the text underscores these interpretations. This paper therefore reads the MSS and supposes that the EE passage introduces a wider focal meaning based on the theory presented in the Categories, one that does not imply referential relationships between the primary and secondary terms. This wider focal meaning can help explain disputed terms in practical philosophy, such as “friendship” and “like-mindedness,” without invoking the Form of the Good.
Picturing the Cosmos through Legal Metaphors – חקק as a Case Study
Authors: Yuan Wenxuan
Published: August 2024

This article examines the Hebrew Bible’s use of legal metaphors in its depiction of the material cosmos (exemplified by the use of חקק) and compares it with the same phenomena in Mesopotamian texts (exemplified by the use of kittu). This study shows that the two metaphors are of two different types: the one around חקק is »legislative«, in which the creator-legislator imposes laws on the cosmos to ensure the regularity in its working; the one around kittu is »judicial«, in which the divine judge reveals his decision over divinatory cases truthfully through cosmic phenomena.
Physical Performance Is Affected by Players' Position, Game Location, and Substitutions During Official Competitions in Professional Championship English Football
Authors: Chaize Chloe , Allen Matt , Beato Marco
Published: August 2024

Chaize, C, Allen, M, and Beato, M. Physical performance is affected by players’ position, game location, and substitutions during official competitions in professional Championship English football. J Strength Cond Res XX(X): 000–000, 2024—This study aimed to verify, first, if physical parameters were different between positions during official matches in the English Football League Championship. Second, whether game location (home vs. away games) and playing status (full match vs. substitute) affected players' physical performance. Twenty-six, male, professional, football players of the same club were included in this data analysis during the 2023–24 season. STATSports 10 Hz global navigation satellite systems Apex units (Northern Ireland, United Kingdom) were used to monitor official matches (21 games). The metrics recorded were distance covered (m·min−1), high-speed running distance (>19.8 km·h−1), sprint distance (>25.2 km·h−1), the number of accelerations (>3 m·s−2), decelerations (<−3 m·s−2), and high-metabolic-load distance (HMLD) measured in meters (>25.5 w·kg−1). Significant differences were found between positions and game location for distance covered and high-speed running (HSR; p < 0.05) as well as between game location (p = 0.020) for sprinting distance. Differences were found between game location (p = 0.034) for decelerations. Differences were found between positions and game location for HMLD (p < 0.05). Significant difference between full-match players vs. substitutes were found for distance covered (p < 0.001), HSR (p = 0.002), accelerations (p = 0.017), decelerations (p = 0.023), and HMLD (p = 0.008). In conclusion, this study found that physical performance was influenced by players' positions and player status, whereas it found that game location affected a minor number of physical metrics. Therefore, practitioners should be aware that training should be tailored based on the physical demands of the players' positions. Moreover, practitioners and managers need to be aware of the positive impact of substitutions on match intensity.
Leitura e enunciação
Authors: Oldoni Cristiano , Cesar de Freitas Ernani
Published: August 2024

As possíveis associações entre os estudos de natureza enunciativa e as manifestações discursivas do campo literário representam um produtiva estratégia para o resgate de sentidos projetados pelo texto, e a sistematização de dispositivos e instrumentos que se voltem a essa prática surge como necessidade. A partir do cenário apresentado, este estudo propõe como objetivo reconhecer como os conceitos de “cena de leitura” e “cena de enunciação” podem contribuir para a construção de sentidos. Baseando-se especificamente nas contribuições de Maingueneau (1996, 2008, 2010) acerca da leitura como co-enunciação e da cena enunciativa, esta análise apresenta pesquisa qualitativa com abordagem bibliográfica na análise de corpus representado por um conto de Vivina de Assis Viana e aponta para a decisiva colaboração que a co-enunciação e a interação de sujeitos exercem quando a temática em foco é uma leitura que privilegia a ampla recuperação de sentidos.
Recent Visual Experience Reshapes V4 Neuronal Activity and Improves Perceptual Performance
Authors: Stan Patricia L. , Smith Matthew A.
Published: August 2024

Recent visual experience heavily influences our visual perception, but how neuronal activity is reshaped to alter and improve perceptual discrimination remains unknown. We recorded from populations of neurons in visual cortical area V4 while two male rhesus macaque monkeys performed a natural image change detection task under different experience conditions. We found that maximizing the recent experience with a particular image led to an improvement in the ability to detect a change in that image. This improvement was associated with decreased neural responses to the image, consistent with neuronal changes previously seen in studies of adaptation and expectation. We found that the magnitude of behavioral improvement was correlated with the magnitude of response suppression. Furthermore, this suppression of activity led to an increase in signal separation, providing evidence that a reduction in activity can improve stimulus encoding. Within populations of neurons, greater recent experience was associated with decreased trial-to-trial shared variability, indicating that a reduction in variability is a key means by which experience influences perception. Taken together, the results of our study contribute to an understanding of how recent visual experience can shape our perception and behavior through modulating activity patterns in the mid-level visual cortex.
In the Name of the King
Authors: Haberkorn Tyrell
Published: August 2024

A decade on from the country’s last coup, aggressive use of a law shielding the monarchy from criticism has blocked a real return to democracy.
Knowledge, Attitude, and Practices Toward Snakes and Snakebites among Non-Medical College Students in Cebu, Philippines: A Mixed Method Approach
Authors: Mutya Romel , Inocian Edsel
Published: August 2024

Understanding community perceptions and behaviors toward snakes is crucial for effective prevention and management in regions where snakebites are a public health concern. Non-medical college students, a significant demographic, can influence broader community health practices and awareness. This study aims to assess the knowledge, attitudes, and practices (KAP) towards snakes and snakebites among non-medical college students in a technological university in the fifth district of Cebu, Philippines. Employing a convergent parallel research design, quantitative data were collected through structured questionnaires, while qualitative insights were obtained via semi-structured interviews. The sample included 546 non-medical college students selected through random sampling. The findings revealed significant gaps and misconceptions, with students exhibiting moderate knowledge about snakes and snakebites. Attitudes were predominantly negative, characterized by fear and aversion. Practices concerning snakebite management needed to be revised, with many students relying on traditional rather than evidence-based methods. The study highlights considerable areas for improvement in the knowledge and practices of non-medical students regarding snakebite management, coupled with generally negative attitudes toward snakes. The novelty of this research lies in its focus on non-medical college students and specific demographics within a technological university, providing insights that can inform targeted educational interventions. Implementing educational programs to improve KAP among students is recommended, emphasizing correct snakebite first aid and fostering a more informed and balanced view of snakes. This research has significant implications for public health, suggesting that targeted education can enhance community health practices and awareness regarding snakebite prevention and management.
Patrimonio histórico del valle bajo del río Chillón. Investigación y educación
Authors: Cabanillas Delgadillo Virgilio Freddy , Fabbri García Martín , Jaime Tello Cecilia , Sánchez Crisóstomo Nancy , Silva Sifuentes Jorge Elías Tercero
Published: August 2024

This article examines approaches the cultural heritage characteristics of the Lower Chillón River Valley populations, from a multidisciplinary perspective: archaeology, history, architecture and education. In order to accomplish such goal, it is discussed the history and current state of the Pre-Hispanic, Colonial and Republican cultural legacy of the studied area, along with its conservation and implementation of educational programs for the local community.
Bibliothekarische Bedienung Bürger-Soldaten Sowjetlitauens in Den Jahren des Grossen Vaterländischen Krieges
Authors: Sinkevičius Klemensas
Published: August 2024

Nach den schweren Schutzkämpfen wurde im August 1941 das aus der ehemaligen litauischen Armee zusammengesetzte 29. Territoriale Korps aufgelöst. Die Bibliotheken seiner Truppen gingen verloren.
Im sowjetischen Rücken wurde im Frühjahr 1942 die 16. litauische Schützendivision der Roten Armee gebildet. In ihren Truppen wurden Soldatenbibliotheken eingerichtet. Litauer wurden auch in andere Truppen der Roten Armee zum Militärdienst einberufen. Die Bestände ihrer Bibliotheken wurden durch die Presse in litauischer Sprache erweitert.
Celebration of the 400th anniversary of the Lithuanian book
Authors: Žukas Vladas
Published: August 2024

In 1947, Lithuania celebrated the 400th anniversary of the first Lithuanian book, M. Mažvydas's Cathechismus, published in 1547. During this celebration, scientific conferences and book exhibitions were organized, and several significant works devoted to the anniversary were published.
Among these was one of the most artistic editions: "The First Lithuanian Book" (a photographic text of the Cathechismus and its transliteration in Latin letters, with articles by J. Kruopas and illuminations by M. Bulakas). In the collection of articles "Ancient Lithuanian Book," significant research in the history of the book and literature was presented, including K. Korsakas's "The First Lithuanian Book," V. Mykolaitis's "Artistic Elements in the Works of Mažvydas and His Contemporaries," P. Galaunė's "Artistic Design of Mažvydas's Book," and V. Abramavičius's "Printing-Offices of Ancient Lithuanian Books." These works addressed issues such as the conditions under which the first Lithuanian book was published, its significance, the date of its publication, its intended audience, authorship and collaboration issues, and analyses of the published texts from linguistic, literary, pedagogical, and ethnographic perspectives, as well as typographical particularities.
Some material from the jubilee celebration, such as reports from conferences, was published in the "Directory of the Academy of Sciences of the Lithuanian SSR" (1948, vol. 2). Jubilee reports by V. Mykolaitis, "The First Lithuanian Book" (1948), and K. Korsakas, "Development of Lithuanian Book over 400 Years" (1948), were published separately. During the anniversary year, the first Lithuanian book and other works by M. Mažvydas were extensively investigated, defining their significance for linguistic science, cultural history, and the expansion of literature, and showing the historical development of Lithuanian book publishing.
Unknown publication about Francisk Skorina's works
Authors: Nemirovskij Jevgenij
Published: August 2024

Included are data about unknown book trade announcements from 1786 and a short article by historian and bibliographer L. I. Bacmeister, which first introduced a number of Francisk Skorina's publications into scientific practice.
Estonian book historiography
Authors: Lott Mare
Published: August 2024

he scientific study of the history of the Estonian book began in the 1930s, and some essays published then have not lost their value up to the present. During this period, the fundamentals of book statistics and the first comprehensive history of the Estonian book by F. Puksoo were published. The attention of researchers was mainly concentrated on 16th-17th, and partly 18th-century publications.
During the post-war period, there was no leading center for book study, and the research concentrated at the major libraries. The problems of book history and research were also studied in the Department of Bibliography, first at Tartu University and then at Tallinn Pedagogical Institute.
In the 1960s, Estonian post-war book historiography achieved more serious results. Republican scientific conferences on book study became a significant factor in the development of book science. The opportunities for publishing improved significantly. The entire potential was used for the collective monograph about the history of the Estonian book, which commemorated the 450th anniversary of Estonian printed books in 1975. In the 1980s, researchers' attention was concentrated on the development of printing.
During more than 50 years of study of books and book problems, a large body of factual material has been assembled and generalized. However, the development of the theoretical basis of the study of the Estonian book and the publication of research results is hindered by the lack of a center for scientific book study.
Development and application of an algorithm to estimate the effective energy of x-rays on conventional mammography
Authors: Merma Velasco Fiorela , Bellotti Mariela , Andres Pablo
Published: August 2024

Mammography is a radiation medical exam, which makes detection of mammary microcalcifications possible at an early stage. The dose received by the patient’s breast is known as the average glandular dose, which is considered a quality control indicator. Estimation of this parameter implies knowing the effective energy of the x-ray beam delivered. This is the case when thermoluminescent dosimetry is the method of choice. The algorithm developed to discriminate the x-ray energy the mammography patient has been exposed to while undergoing routine procedures, applies two thermoluminescent dosimeters, one of them filtered by a 1 mm thick aluminum layer. The effective energy of the x-ray beam and the correction factor are obtained by knowing the relation between the filtered and non-filtered dosemeters readout. This algorithm was then used to estimate the average glandular dose following the IAEA TRS 457 protocol. The dose values computed were compared with the international diagnostic reference levels suggested by the technical literature.
Hipnokomunikasi Dalam Aplikasi Pasha (Pain Assessment, Stimulating And Healing Application) Dalam Menurunkan Nyeri Pasien Post Operasi
Authors: Rezkiki Fitrianola , Kartika Imelda Rahmayunia , Ceria Nabila Puti
Published: August 2024

Postoperative pain is the body’s reaction to tissue damage (ranging from skin incisions to damage from surgery), stretching or tightening of internal organs, and diseases (eg cancer, spinal diseases, etc). There are several pain management options in the PASHA (Pain Assessment, Stimulating and Healing Application) application to reduce the pain scale felt by patients, one of which is hypnocommunication. The purpose of this study was to find out how effective hypnocommunication on reducing pain of postoperative patients. This study used a quasy experimental design with a one-group pre-test and post-test approach by measuring the pain scale using the NRS (Numeric Rating Scales). The sample of this study was 30 postoperative patients in the surgical room who were selected by purposive sampling with several inclusion criteria.. The intervention was carried out using the PASHA application and the patient was listened hypnocommunication therapy for 15 minutes in 2 consecutive days The data were collected through computerization by using an dependent t-test. The results of the study showed that the average respondent’s pain intensity before being given hypnocommunication was 5.167 (moderate pain) and the average repondent’s pain intensity after being given hypnocommunication was 4, 00 (moderate pain). It can be conclude there was a significant effect of providing hypnocommunication based on the PASHA application in reducing postoperative patient pain (p value = 0.001). It is recommended to nurses especially in treating pain of postoperative patients by applying hypnocommunication as a non pharmacological pain therapy
Genomic characterization of an uncommon Delftia acidovorans isolate obtained from a Bulgarian immunocompetent outpatient diagnosed with bronchitis
Authors: Peykov Slavil , Gergova Raina , Atanasova Svetlana , Dimov Svetoslav G. , Strateva Tanya
Published: August 2024

Delftia acidovorans is an aerobic, non-fermenting Gram-negative bacterium (NFGNB), found in soil, water and hospital environments. It is rarely clinically significant, most commonly affecting hospitalized or immunocompromised patients. The present study aimed to explore the genomic characteristics of a Bulgarian clinical D. acidovorans isolate (designated Dac759) in comparison to all strains of this species with available genomes in the NCBI Genome database (n = 34). Dac759 was obtained in 2021 from the sputum of a 65-year-old female immunocompetent outpatient with bronchitis. Species identification using MALDI-TOF mass spectrometry, antimicrobial susceptibility testing, whole-genome sequencing (WGS), and phylogenomic analysis were performed. The isolate demonstrated high-level resistance to colistin (16 mg L−1); resistance to gentamicin; reduced susceptibility to piperacillin, piperacillin-tazobactam, ceftazidime, cefepime, ciprofloxacin, and levofloxacin; and susceptibility to imipenem, meropenem, amikacin, and tobramycin. The observed genome size (6.43 Mb) and GC content (66.76%) were comparable with the accessible data from sequenced D. acidovorans genomes. A limited number of resistance determinants were identified in the assembled genome as follows: blaOXA-459, emrE, oqxB, and mexCD-oprJ. The phylogenomic analysis indicated a high heterogenicity of the included D. acidovorans genomes. In conclusion, to the best of our knowledge, this is the first documented case of a clinically relevant D. acidovorans isolate in Bulgaria. Unlike the majority of reports in the literature, Dac759 affected a patient with no malignancies or other preexisting comorbidities. With this in mind, its genome sequence is a valuable resource for the fundamental study of uncommon bacterial pathogens of public health importance.
Characterisation and biological activities of synthesised copper oxide nanoparticles from the Pimpinella anisum L. aqueous extract
Authors: Sücü S. , Demir N.
Published: August 2024

Nanoparticles can be synthesised by several methods. Due to the long duration, high cost, and toxic by-products of chemical and physical methods, the biological method has become more preferred. Among various sources such as bacteria, fungi, or yeast, the use of plants in biological synthesis has proven to be the most ideal. Many metals can be used in the biological method, including copper oxide (CuO). In this study, copper oxide nanoparticles (CuONPs) were synthesised using Pimpinella anisum L. aqueous extract. For characterisation of the CuONPs, UV–Visible Spectroscopy (UV–Vis), Scanning Electron Microscopy (SEM), Energy Dispersion Spectroscopy (EDS), and Fourier Transform Infrared Spectroscopy (FT-IR) analyses were performed. The biological activity of the P. anisum extract and CuONPs was determined using DNA cleavage (agarose gel electrophoresis), antioxidant (1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity and hydrogen peroxide scavenging activity), mutagenic (Ames/Salmonella test), and catalytic (methylene blue degradation) activities. In DNA cleavage activity test, CuONPs completely denatured DNA at high concentrations (100 and 200 μg mL−1) due to their oxidative activity. The results showed that both the extract and CuONPs have antioxidant properties in DPPH and hydrogen peroxide scavenging activities. According to the mutagenicity, CuONPs did not have a mutagenic effect. In catalytic activity, CuONPs degraded methylene blue within 240 min by 99.45%.
Moral dilemmas and limitations in global health practice
Authors: Larson H Elliott
Published: August 2024

.
Evaluation of physicochemical, textural, and sensory properties of reduced-fat chicken patties produced with chia flour and κ-carrageenan
Authors: Kesemen Ali Murat , Akköse Ahmet
Published: August 2024

The effects of chia flour and κ-carrageenan on the physicochemical, textural, and sensory properties of reduced-fat chicken patties were investigated. Usage of chia flour decreased pH, while addition of κ-carrageenan increased it. Chicken patties with chia flour had higher thiobarbituric acid reactive substances (TBARS) and lower L*, a*, and b* values. Production stages significantly affected pH, TBARS, and color of the samples (p < 0.01); while pH, TBARS, a*, and b* values increased and L* value decreased after cooking. Adding chia flour and Kappa-carrageenan (κ-carrageenan) to reduced-fat chicken patties increased cooking yield and moisture retention while decreasing the shrinkage. Chia flour and κ-carrageenan increased hardness of samples and the highest mean value was found to be 68.70 ± 1.40 N in the group containing 8% beef fat + 4% chia flour + 5% breadcrumbs + 1% κ-carrageenan. However, adhesiveness and cohesiveness decreased by addition of chia flour and κ-carrageenan. Among the sensory properties, flavor, texture, and general acceptability were significantly affected by the addition of chia flour and κ-carrageenan (p < 0.01). Sensory properties were studied by panelist, and it was found that usage of 2% chia flour and 1% κ-carrageenan in reduced-fat chicken patties could be effective regarding product quality, health benefits, and consumer acceptance.
Influência do momento da leucorredução de hemocomponentes na evolução clínica de pacientes transfundidos na emergência
Authors: Silva Natasha Dejigov Monteiro da , Herbst Ana Catharina , André Milena Raquel , Nogueira Lilia de Souza
Published: August 2024

RESUMO Objetivos: verificar a influência do momento da leucorredução (pré ou pós-armazenamento) de hemocomponentes na evolução clínica de pacientes transfundidos na emergência. Métodos: coorte retrospectiva de pacientes com idade igual ou maior de 18 anos que receberam, no departamento de emergência, concentrado de hemácias ou plaquetas leucorreduzidas pré ou pós-armazenamento. Modelo de efeitos mistos generalizado foi aplicado nas análises. Resultados: na amostra de 373 pacientes (63,27% homens, idade média 54,83) e 643 transfusões (69,98% concentrado de hemácias) foi identificado que o momento da leucorredução influenciou o tempo de internação hospitalar dos pacientes (p<0,009), porém não foi dependente do hemocomponente transfundido (p=0,124). O momento da leucorredução não teve efeito (p>0,050) nas variáveis reação transfusional, infecção relacionada à assistência à saúde e óbito. Conclusões: pacientes que receberam na emergência hemocomponente leucorreduzido pré-armazenamento apresentaram menor tempo de internação hospitalar.
A insólita a-generidade da filosofia masculinizante
Authors: Sattler Janyne
Published: August 2024

Resumo: O objetivo deste artigo é repassar os termos de uma chamada para dossiê temático e responder criticamente a algumas perguntas suscitadas por sua linguagem e por alguns dos conceitos presentes nos requisitos listados para o aceite das publicações. Assim, começa-se por perguntar sobre o significado (linguístico-político) da generificação do pensamento filosófico tomando como chave crítica de leitura uma parte da vasta produção das epistemologias feministas, a fim de insistir na parcialidade e na localização de toda e qualquer manifestação filosófica contra a especificidade do gênero feminino relativamente à autoridade epistêmica e à autoria textual em filosofia; em seguida, trata-se da distinção entre ‘sexo’ e ‘gênero’ para proceder a uma correção quanto à enunciação quase biológica sobre o ato de escrita filosófica; e, por fim, trazem-se questões sobre a generificação dos “conteúdos” filosóficos e sobre os interesses da filosofia feminista e da história feminista da filosofia, de sorte a se proceder à denúncia sobre os modos como nossa linguagem filosófica e seus suportes epistemológicos de fundo seguem ainda as sendas dicotômicas valoradas desigualmente.
“ENCHANTED” SCIENCE TEACHING: DECOLONIAL STUDIES BASED ON MACUMBAS PRACTICES AND SACRED CROSSROADS
Authors: REBELLO THIAGO JOSÉ JESUS , LIMA ROGERIO MENDES DE , MEIRELLES ROSANE MOREIRA SILVA DE
Published: August 2024

ABSTRACT: coloniality is a concept that reflects colonialist power's racist patterns in contemporary context. Drawing on the Epistemology of the Brazilian Macumbas and the Pedagogy of Crossroads, formulated by Luiz Rufino and Luiz Antônio Simas, we advocate for an “enchanted” approach to science teaching: an opportunity to transcend coloniality through science education. Initially, we situate the works of the authors Simas and Rufino within decolonial thought. Subsequently, we explore the underpinnings of the Epistemology of the Brazilian Macumbas Practices and the Pedagogy of Crossroads, emphasizing the notions of “enchantment” and crossroads. We conclude the article by proposing a perspective called “enchanted” teaching of science based on critiquing western-centricity and fostering interculturality.
SPECIAL EDUCATION PUBLIC-PRIVATE FUNDING: WHO WINS AND WHO LOSES IN THE BENEMERENCE MARKET?
Authors: NUNES LORRANA OLIVEIRA , RODRIGUES ANA CLÁUDIA DA SILVA
Published: August 2024

ABSTRACT: This article aims to analyze the game of disputes and negotiations for public resources between public-private partnerships in special education funding. The discussions come from the bibliographic and documental review of works aligned with our objective, supported by the theoretical assumptions of historical-dialectical materialism (MARX, 1985). In the context of the State's exoneration concerning social policies, we perceived in the consulted sources that the public-private partnerships win the dispute in the benemerence market to the expense of the special education public, seeking the resources of public funding and participation in the direction of educational policies. It was also evident that the partnership between the State and the private sector contributed to public education precariousness, fueling tensions between conquered and effective rights and the non-compliance with PNE 2014-2024 goals and the agreements signed between Brazil and international organizations, such as the Declaration of Salamanca (1994). On the other hand, the findings revealed some exit ways to combat the social and educational apartheid disseminated by the business class seeking to dispute for the public fund: develop organization capacity, access to information, and internal communication to ensure public investments; overcome centralized management in school spaces; and strengthen social control through social and popular participation.