bluuebunny/crossref_metadata_2025 huggingface dataset:
A Rare Case of Humerus Synovial Sarcoma Originated from Bone Tissue: Case Report
Authors: Heidari Mohsen , Izadi Mehdi , Hatami Saeed
Published: February 2023

Synovial sarcoma (SS) is a malignant mesenchymal neoplasm that is relatively common in the distal extremities. Primary SS of bone is an extremely rare finding. Here in this report, we present a 44-year-old male patient referred with bone and later bone fracture that was finally diagnosed with primary SS of thumerus. So far, 13 documented cases of primary SS of the bone have been reported. The current case is the second known case of primary SS of humerus. Our case was treated with both neoadjuvant and adjuvant chemotherapies associated with surgical tumor removal and prosthesis implantation. Follow-up of the case demonstrated significant remission but with late metastasis and subsequent advanced chemotherapy regimens.
Phospholipase Activity of Candida Species Isolated from Diabetic Patients
Authors: Amini Negar , Mohammadi Rasoul
Published: February 2023

Background:

Candidiasis is one of the prevalent fungal infections caused by the genus Candida. The clinical manifestation ranges from mucocutaneous colonization to disseminated and fatal infections such as candidemia. Diabetes mellitus is one of the significant predisposing factors for this fungal infection. Candida spp. may release many exoenzymes such as phospholipase to debilitate the immune system and facilitate adherence and invasion of the fungus to the host cells. The aim of the present study is evaluation of phospholipase activity of Candida species isolated from candidemia and gastroesophageal candidiasis (GEC) among diabetic patients.

Materials and Methods:

Eighty-three Candida isolates were evaluated for enzyme activity by phenotypic (the precipitation zone around the colonies) and molecular methods (detection of phospholipase genes using duplex polymerase chain reaction with specific primers).

Results:

Eight out of eighty-three clinical isolates (9.6%) were negative for phospholipase production. All phospholipase producers among candidemia and GEC isolates were categorized in high production group.

Conclusions:

Our findings revealed no differences in phospholipase activity among isolates obtained from different body sites (blood, oesophagus and stomach); however, non-albicans Candida species had less phospholipase activity.
Central retinal artery occlusion with cilioretinal artery sparing secondary to COVID-19: Additional ocular complication
Authors: de Oliveira Marcela RV , Lucena Ana Regina VP , Higino Taciana MM , Ventura Camila V
Published: February 2023

We describe a 68-year-old female patient with unilateral central retinal artery occlusion (CRAO) with cilioretinal artery sparing post-coronavirus disease 2019 (COVID-19) infection. The patient presented with acute vision loss in the left eye 11 days after discharge from a severe COVID-19 infection, with altered D-dimer, C-reactive protein, and fibrinogen levels. The best-corrected visual acuity (BCVA) in the left eye was 20/400; fundoscopic examination revealed diffuse pallor retina with a patent arterial branch from the optic disk to the fovea, confirmed by fluorescein angiography. CRAO with a cilioretinal artery sparing post-COVID-19 may be considered an additional ocular manifestation of the post-acute COVID-19 syndrome spectrum.
Effect of dexamethasone implant on intraocular cytokines in diabetic macular edema
Authors: Pillai Gopal S , Gupta Akanksha , Xavier Tessy , Radhakrishnan Natasha , Menon Krishnakumar N , Rasheed Rehna , Ravindran Greeshma C
Published: February 2023

Purpose:

Our primary aim was to evaluate intraocular cytokines (IC) before and after dexamethasone in diabetic macular edema (DME). Our secondary aim was to study the early and late effects of single dexamethasone implant in DME.

Methods:

This before and after comparative study was conducted at the Department of Ophthalmology and Centre for Nanosciences at a quaternary referral center in Kerala, India, from September 2016 to September 2018. Patients underwent complete ophthalmological examination and cytokine analysis before and after dexamethasone implant. Levels of cytokines at baseline and repeat sample were studied.

Results:

Twenty-seven eyes (21 patients) were divided into two groups depending on time from baseline to second injection. Group 1 included patients with <3 months between the two samples – 12 (44.4%). Group 2 included patients with >3 months between the two samples –15 (55.6%). Best corrected visual acuity (BCVA) and central macular thickness (CMT) improved significantly post-dexamethasone in group 1, but not in group 2. Interleukin (IL)-4, IL-6, IL-10, vascular endothelial growth factor (VEGF), IL-1β, interferon-gamma inducible protein-10 (IP-10), monocyte chemoattractant protein-1 (MCP-1), and IL-2 decreased post-injection in group 1. But cytokines increased post-dexamethasone in group 2, except IL-10. When compared to baseline, IL-6 reduced to half in group 1 (P-value 0.814) and it tripled in group 2 (P-value 0.009). The level of VEGF in the first and second samples was not different in either group.

Conclusion:

Our study suggests that dexamethasone acts more on IC than VEGF in DME. This is significant in the first 3 months with a rebound effect on IL-6 after 3 months. Our study also suggests that repeat injection of DEX in DME should be done at 3 months to prevent deterioration of visual acuity (VA) and worsening of CMT.
Demographic profile and clinical characteristics of Fuchs’ endothelial corneal dystrophy in a tertiary eye care center
Authors: Bhadra Pratik , Sahoo Sonali , Sahu Srikant K , Priyadarshini Smrutirekha , Mohanty Amrita , Das Sujata
Published: February 2023

Purpose:

This study was performed to determine the demographic profile and clinical characteristics in patients with Fuchs’ endothelial corneal dystrophy (FECD) reporting to a tertiary eye care center in India. It is a retrospective, single-center, observational study.

Methods:

The study included 280 patients (559 eyes) diagnosed with FECD presenting between January 2013 and December 2020. The data was collected from the electronic medical record system of the institute. Patient data included demographic features, clinical characteristics, investigations, and surgical interventions.

Results:

The mean age of the patients was 62 years. Late-onset FECD (95.7%) was more common than early-onset FECD (4.3%). Male: female ratio for late-onset FECD and early-onset FECD was 1:1.65 and 3:1, respectively. More than one-third of the patients had associated systemic history. Preexisting ocular diseases were seen in 5.9% of eyes. Blurring of vision was seen in 383 eyes (68.5%), 13 eyes (2.1%) had glare, and 163 eyes (29.2%) were asymptomatic. A total of 113 surgical interventions were done in 108 eyes (including repeat transplants). Only cataract surgery was done in 40 (7.2%) eyes, whereas penetrating keratoplasty, Descemet stripping endothelial keratoplasty, and Descemet membrane endothelial keratoplasty without or with cataract surgery (sequential or triple procedure) were done in 12 (2.1%), 47 (8.4%), and 14 (2.5%) eyes, respectively.

Conclusion:

Patients with FECD present mostly during the sixth decade. Posterior lamellar keratoplasty is the most common transplant procedure being performed on FECD patients.
Long-term outcomes of transcutaneous retrobulbar amphotericin B in COVID-19-associated mucormycosis
Authors: Rizvi Syed Wajahat A , Khan Shagil , Shahbaz Mohammad , Gounder M Srinivasan , Saif Mohd , Khalid Saifullah
Published: February 2023

Purpose:

To describe the long-term outcomes of transcutaneous retrobulbar amphotericin B (TRAMB) in COVID-19-associated mucormycosis.

Methods:

In total, 18 cases of COVID-19-associated mucormycosis were reviewed. In addition to the recommended treatment protocol, all patients were to be given 3.5 mg/ml/day of TRAMB for five days.

Results:

Of the 18 patients, 2 presented with stage 3a disease, 13 had stage 3c disease, and 3 patients had central nervous system (CNS) involvement (stage 4a and 4c). In addition to planned retrobulbar doses, five patients were given more while two patients received fewer injections (i.e., <5). At the last mean follow-up of 34.67 (±8.88) weeks, 11 patients were in radiological regression and 4 had stable disease while 2 patients had to undergo exenteration; one mortality was observed because of disease progression. Clinical regression in terms of visual and ptosis improvement was seen in seven and nine patients, respectively.

Conclusion:

Rhino-orbito-cerebral mucormycosis is a serious condition which warrants an aggressive treatment strategy. In unprecedented situations witnessed recently, TRAMB turned out to be an effective and economical alternative. Though large randomized studies are needed to establish its efficacy, TRAMB still manages to halt progression and salvage the globe in significant number of patients, and hence its use should be encouraged on a case-to-case basis especially in developing countries with limited resources.
Intra-arterial chemotherapy in refractory and advanced intraocular retinoblastoma
Authors: Kumari Namita , Jain Nishchint , Saboo Surbhi , Parthasarathy Rajsrinivas , Gupta Vipul , Mahajan Amita , Das Sima
Published: February 2023

Purpose:

To evaluate the efficacy of secondary and salvage intra-arterial chemotherapy (IAC) as a globe salvage treatment modality in advanced and refractory intraocular retinoblastoma.

Methods:

A retrospective chart review of advanced intraocular retinoblastoma (groups D and E International Classification of Retinoblastoma [ICRB] classification) patients refractory to intravenous chemotherapy (IVC) and undergoing IAC as the secondary and salvage treatment modality between December 2018 and June 2021 was carried out. All patients underwent the IAC procedure by super-selective ophthalmic artery catheterization and with triple-drug chemotherapeutic agents of melphalan, topotecan, and carboplatin. Data were collected about tumor regression, eye salvage, metastasis, and survival outcome at follow-up.

Results:

Out of 13 patients, 12 patients received secondary IAC after being primarily treated with IVC and focal therapies and one patient received rescue IAC after recurrence following primary IAC. Mean number of IAC cycles administered was 2. Overall, globe salvage rate was 53.84%, with a mean follow-up of 17.53 months (range 6–37 months), three patients had enucleation for residual tumor or tumor recurrence. One patient developed metastasis post enucleation and two patients who were lost to follow-up after enucleation advice for residual tumor developed orbital tumor extension and eventually died of metastasis.

Conclusion:

Secondary triple-drug IAC following failure of IVC, along with other adjunct treatment modalities might a be a cost-effective option for eye salvage in advanced intraocular retinoblastoma patients who refuse enucleation, with a globe salvage rate of 53.84%. It can also be an effective approach to improve treatment compliance and can help in addressing the barrier of treatment refusal when enucleation is advised.
Parental perception of facilitators and barriers to activity and participation in an integrated tele-rehabilitation model for children with cerebral visual impairment in South India – A virtual focus group discussion study
Authors: Philip Jannet , Hussaindeen Jameel Rizwana , Jacob Namita , Sethuraman Saranya , Swaminathan Meenakshi
Published: February 2023

Purpose:

This study utilized virtual focus group discussions to document the facilitators and barriers reported by the parents as part of the tele-rehabilitation service delivery model in India.

Methods:

This study included 17 participants who were enrolled into the Tele-rehabilitation program (16 mothers, 1 father) and the virtual focus group discussion (V-FGD) were conducted through a WhatsApp video call. Three V-FGDs were conducted involving two moderators and a note taker. The V-FGD, focused at extracting the perceptions of parents pertaining to facilitators, barriers and coping mechanisms to barriers related to the tele-rehabilitation model.

Results:

Thematic analysis resulted in four themes for barriers that included: family and support, time, parent and care taker, child and place of living related; facilitators reported included: continuous monitoring, accessibility to professional services, provision of resource materials and parental empowerment. Themes “family and support” and “child” were most reported by parents with children >3 years and ≤3 years respectively. Finally, the barriers and facilitators were aligned with the chapters and codes of International Classification of Functioning, children and youth version (ICF-CY) environment and personal factors.

Conclusion:

This V-FGD highlights the importance of parental-centred and structured Tele-rehabilitation among children with CVI in India. The outcome of this study opens avenues for creating effective intervention.
Awareness and knowledge among paramedical staff about glaucoma surgeries and post-surgery counseling – A questionnaire based study at a tertiary eye care center in Central Rural India
Authors: Shakya Rakesh , Ahluwalia Navjot Singh , Shah Chintan , Paul Pulak , Jain B K , Pandit Kushal , Gupta Ramesh KC , Ahlawat Reena , Choudhary Priyanka
Published: February 2023

Purpose:

To determine the level of awareness and knowledge about glaucoma surgery and post-surgery counseling amongst paramedical staff at a tertiary eye-care hospital.

Methods:

This observational cross-sectional study included a random sample of 94 hospital personnel: 37 general nurse midwives, 47 ophthalmic assistants, and 10 patient caretakers (PCTs). Participants were administered a questionnaire about glaucoma surgery and post-surgery counseling of patients.

Results:

The study included 41 (43.6%) females and 53 (56.4%) males. The mean age of the participants was 24.85 ± 4.54 years. All participants were aware of trabeculectomy surgery in glaucoma (100%). A total of 95.7% knew that surgery helps in controlling IOP, of whom 57 (60.6%) participants got information during their course of learning. Overall 53 (56.4%) believed that surgery is done when medication failure occurs, and 58 (61.7%) knew that surgery helps in preserving vision. A total of 63 (67.0%) participants knew to counsel patients to visit an ophthalmologist when called for and take the treatment as advised, whereas 74 (78.7%) correctly said to visit an ophthalmologist immediately if pain/diminution of vision/discharge occurs. Overall, PCTs were found to be having significantly better knowledge (P = 0.01) compared to others and they also reported ophthalmologists as the chief source of information.

Conclusion:

This study revealed that paramedical staff had an excellent awareness of trabeculectomy surgery. However, the knowledge and counseling parts of the questionnaire revealed less than satisfactory responses. So, there is a need to continuously educate paramedical staff members so that they can help in propagating information about the role of glaucoma surgery and the importance of proper follow-up.
Risk factors for secondary ocular hypertension in silicone oil-filled eyes following transconjunctival sutureless vitrectomy – A prospective cohort study
Authors: Prathapan Manoj , Shyam Praveena , Pillai Gopal S
Published: February 2023

Purpose:

Our aim was to determine the various risk factors for secondary ocular hypertension (OHT) following pars plana vitrectomy (PPV) with silicone oil (SO) injection.

Methods:

A prospective cohort study was performed on 46 eyes of 42 patients who underwent PPV with SO injection under a single surgeon between January 2020 and July 2021. Complete ophthalmological examination including gonioscopy and Goldmann applanation tonometry was performed preoperatively and on three postoperative visits, that is, day 7, day 30, and day 90. Axial length and lens thickness were measured at baseline using immersion A-scan. Anterior segment optical coherence tomography (OCT) was used for measuring anterior chamber depth (ACD) at baseline and at 3 months.

Results:

There was a statistically significant increase in intraocular pressure (IOP) (>21 mmHg) on day 7 (4.70 ± 7.754 mmHg), day 30 (5.24 ± 7.481 mmHg), and day 90 (2.39 ± 5.659 mmHg) (P<0.01 for all). Age <50 years, rhegmatogenous retinal detachment (RRD), and pseudophakia had a strong association with short-term OHT on day 7. Preexisting glaucoma was the only independent risk factor for long-term OHT (day 90). Higher baseline IOP and SO emulsification also contributed to long-term OHT.

Conclusion:

There was a statistically significant elevation in IOP at all postoperative visits. Short-term OHT was associated with younger age (<50 years), RRD, and pseudophakia. Patients with emulsified SO in the anterior chamber, higher baseline IOP, and preexisting glaucoma were at higher risk for long-term OHT.
Primary eye care in pediatric population-I study (PREPP-I study): Demographic and clinical profile of pediatric patients treated in six major vision centers of a tertiary eye care facility in South India
Authors: Kalita Iva Rani , Singh Harsh Vardhan , Veena K , Mouttappa Freidrick
Published: February 2023

Purpose:

The study intends to evaluate the demographic and clinical profile of pediatric patients (0–18 years) attending six vision centers (VCs) of a tertiary eye care facility in south India.

Methods:

This is a cross-sectional observation study conducted at six major peripheral VCs of a tertiary eye care facility in South India from June 20 to Dec 20. All children presenting at the VCs under a base hospital (BH) in Pondicherry, whose parents gave consent were included. Data were entered by the ophthalmic assistants in the VC and cross checked by the principal investigator at the BH.

Results:

A total of 250 pediatric patients were brought to the VCs during the study period, predominantly males (60.8%), with a mean age of 8.2 ± 4.5 years (0–18 years). Half of them were staying within 5 km from the VCs. Most children were escorted by their parents (88%), and the expenditure of travel to the VC was affordable for most of the parents (75%). Also, 53.6% of patients were in their primary school, while schooling had not started for 28% of children. Visual acuity (VA) could be assessed only for school-going children and older children due to lack of age-matched VA assessment tools. Most children (91.3%) had uncorrected VA better than or equal to 6/18 in the better eye, and approximately 3% had VA worse than 6/60. All patients had best corrected VA of 6/6–6/18 after cycloplegic refraction. Most children reported to the VC for allergic conjunctivitis (25%), followed by refractive error (13%) and squint (10.4%). Urgent referral to the BH was made for 47 children.

Conclusion:

Primary eye care in pediatric population-I (PREPP-I) showed that most children can be treated at the VCs and only one-fifth of the children require active intervention at higher referral centers. Further study on satisfaction of services provided for pediatric patients in these VCs and barriers of not reporting to the BH when referred are considered for the PREPP-II study.
Retinal nerve fiber layer thinning found in amyotrophic lateral sclerosis – Correlation with disease duration and severity
Authors: Mohanty Bijendra , Misra Amar Kumar , Kumar Sanjay , Guha Gautam , Bhattacharya Annesh , Ngullie Pideno S , Manna Akash , Nanda Tapashya , Mukherjee Joydeep
Published: February 2023

Purpose:

The retinal involvement of amyotrophic lateral sclerosis (ALS) is a novel idea about a possible correlation between retinal nerve fiber layer (RNFL) thickness in different spectra of ALS patients. Finding the association of RNFL with disease duration and severity will help identify a novel noninvasive biomarker.

Methods:

The study was designed as a cross-sectional study and was conducted with a suitable proforma. We included the ALS cases based on the revised El Escorial criteria. Healthy controls were age and gender matched. We used the revised ALS functional rating scale (ALSFRS-R) to assess the operational status of the patients. We measured RNFL thickness in the four quadrants with spectral-domain optical coherence tomography (OCT) and analyzed it.

Results:

We included 30 cases (60 eyes) and 10 healthy controls (20 eyes) having a mean (standard deviation [SD]) age of 49.5 (11.1) years with a median of 50 years, and a majority of them (65%) were middle aged (between 41 and 60 years). We found statistically significant differences in RNFL thicknesses between ALS patients and healthy controls. On segmental analysis, the right eye superior and nasal quadrants and the left eye superior, inferior, and nasal quadrants were significantly affected, along with a gross asymmetry found between the left and right eyes among ALS patients. There was a significant decrease in average RNFL thickness in definite ALS patients than probable ALS patients, with significantly reduced average RNFL thickness in moderate to severe ALS patients. On correlation analysis, disease duration showed a good negative correlation with bilateral average RNFL thickness, and the ALSFRS-R score demonstrated a good positive correlation with bilateral average RNFL thickness, which was statistically significant. Thus, a reduced bilateral RNFL thickness is associated with a decreased ALSFRS-R score.

Conclusion:

The retinal changes can serve as a marker for diagnosing and monitoring patients with ALS.
Impact of crossplay between ocular aberrations and depth of focus in topo-guided laser-assisted in situ keratomileusis outcomes
Authors: Khamar Pooja , Shetty Rohit , Annavajjhala Sriram , Narasimhan Raghav , Kumari Savitri , Sathe Priyanka , Roy Abhijit Sinha
Published: February 2023

Purpose:

To develop a nomogram in cases with mismatch between subjective and Topolyzer cylinder, and based on the magnitude of the mismatch, customize a treatment plan to attain good visual outcomes post-laser-assisted in situ keratomileusis (LASIK) surgery.

Methods:

The patients were evaluated preoperatively using corneal tomography with Pentacam. Five optimal corneal topography scans were obtained from the Topolyzer Vario were used for planning the LASIK treatment. For the nomogram purpose, the patients were divided into three categories based on the difference between the subjective cylinder and Topolyzer (corneal) cylinder. The first group (group 1) consisted of eyes of patients, where the difference was less than or equal to 0.4 D. The second group (group 2) consisted of eyes, where the difference was more than 0.4 D and the subjective cylinder was lesser than the Topolyzer cylinder. The third group (group 3) included eyes where the difference was more than 0.4 D but the subjective cylinder was greater than the Topolyzer cylinder. LASIK was performed with the WaveLight FS 200 femtosecond laser and WaveLight EX500 excimer laser. Assessment of astigmatism correction for the three groups was done using Aplins vector analysis. For comparison of proportions, Chi-square test was used. A P value less than 0.05 was considered statistically significant.

Results:

The UDVA was statistically significantly different when compared between groups 1 and 2 (P = 0.02). However, the corrected distance visual acuity (CDVA) was similar among all the three groups (P = 0.1). Group 3 showed an increase of residual cylinder by −0.25 D, which was significant at intermediate and near reading distances (P < 0.05). Group 3 showed significantly higher target-induced astigmatism (TIA) compared to groups 1 and 2 (P = 0.01). The mean surgically induced astigmatism (SIA) was the least in group 2, which was statistically significant (P < 0.01).

Conclusion:

The outcomes for distance vision using our nomogram postoperatively were excellent, but further refinement for improving the near vision outcomes is required.
Development of the modified Safety Attitude Questionnaire for the medical imaging department
Authors: Eturajulu Ravi Chanthriga , Tan Maw Pin , Zakaria Mohd Idzwan , Chinna Karuthan , Ng Kwan Hoong
Published: February 2023

Introduction:

Medical errors commonly occur in medical imaging departments. These errors are frequently influenced by patient safety culture. This study aimed to develop a suitable patient safety culture assessment tool for medical imaging departments.

Methods:

Staff members of a teaching hospital medical imaging department were invited to complete the generic short version of the Safety Attitude Questionnaire (SAQ). Internal consistency and reliability were evaluated using Cronbach’s α. Confirmatory factor analysis (CFA) was conducted to examine model fit. A cut-off of 60% was used to define the percentage positive responses (PPR). PPR values were compared between occupational groups.

Results:

A total of 300 complete responses were received and the response rate was 75.4%. In reliability analysis, the Cronbach’s α for the original 32-item SAQ was 0.941. Six subscales did not demonstrate good fit with CFA. A modified five-subscale, 22-item model (SAQ-MI) showed better fit (goodness-to-fit index ≥0.9, comparative fit index ≥ 0.9, Tucker–Lewis index ≥0.9 and root mean square error of approximation ≤0.08). The Cronbach’s α for the 22 items was 0.921. The final five subscales were safety and teamwork climate, job satisfaction, stress recognition, perception of management and working condition, with PPR of 62%, 68%, 57%, 61% and 60%, respectively. Statistically significant differences in PPR were observed between radiographers, doctors and others occupational groups.

Conclusion:

The modified five-factor, 22-item SAQ-MI is a suitable tool for the evaluation of patient safety culture in a medical imaging department. Differences in patient safety culture exist between occupation groups, which will inform future intervention studies.
Factors associated with readmission after long-term administration of tolvaptan in patients with congestive heart failure
Authors: Yamashita Shoko , Takenaka Miki , Ohbayashi Masayuki , Kohyama Noriko , Kurihara Tatsuya , Sunaga Tomiko , Ishiguro Hisaaki , Kogo Mari
Published: February 2023

Introduction:

We investigated the factors associated with readmission in patients with congestive heart failure (HF) receiving long-term administration of tolvaptan (TLV) to support treatment decisions for HF.

Methods:

This retrospective cohort study included 181 patients with congestive HF who received long-term administration of TLV. Long-term administration of TLV was defined as the administration of TLV for 60 days or longer. The outcome was a readmission event for worsening HF within 1 year after discharge. Significant factors associated with readmission were selected using multivariate analysis. To compare the time to readmission using significant factors extracted in a multivariate analysis, readmission curves were constructed using the Kaplan–Meier method and analysed using the log-rank test.

Results:

The median age was 78 years (range, 38–96 years), 117 patients (64.6%) were males, and 77 patients (42.5%) had a hospitalisation history of HF. Readmission for worsening HF within 1 year after long-term TLV treatment occurred in 62 patients (34.3%). In the multivariate analysis, estimated glomerular filtration rate (eGFR) <30 mL/min/1.73 m2 (odds ratio, 3.22; 95% confidence interval, 1.661–6.249; P = 0.001) was an independent significant factor. When eGFR at discharge was divided into two groups (eGFR < 30 vs. eGFR ≥ 30), readmission rates within 1 year were 53.3% vs. 25.4%, respectively (P = 0.001).

Conclusion:

We revealed that eGFR was strongly associated with readmission in patients with HF who received long-term administration of TLV. Furthermore, we showed that eGFR is an important indicator in guiding treatment of HF in patients receiving TLV.
The Influence of Innovation Leadership on Employee Performance
Authors: Supriatna Nana , Zulganef Zulganef
Published: February 2023

The last few decades have seen significant research in the fields of innovation and leadership. The act of motivating, influencing, and directing team members toward the intended objectives is referred to as leadership. However, the term of leadership is broad and has various definitions. It encompasses and influences a range of methods, circumstances, aptitudes, and attributes. On the other side, innovative leaders are creative thinkers who may produce concepts that serve as the foundation for innovation. Understanding the principles of leadership and innovation is essential before one can fully comprehend the true meaning of innovative leadership. This study combines the two terms, reviews the innovative leadership style that will be discussed in the literature, and gives a general summary of how the two terms affect employees' performance.
Islamic Education Update K.H. Hasyim Asy’ari
Authors: Amin Misbahuddin , Hasaruddin
Published: February 2023

The characteristic of the Indonesia Islamic education modernism is largely determined by the creativity which the Muslim pointed out. The flexibility of the Islamic education system enable it to easily adapt itself to the surrounding and to create the new and appropriate format of its derivation in line with the new demand of the umma for the field in the modern era. A number of experiments had been performed by the Muslim figures, individually or collectively, to fulfill that demand in the early decades of the 20th century. How did they adopt the elements of modernity to keep the Islamic education remain in its own identity? For this purpose, it is important to understand and to explain the ideas and the efforts of Syaikh Hasyim Asy’ari of Tebuireng in modernizing his pesantren and its main contribution to the development of the new madrasahs in the country. Using the analytical-critical method, this examination is in conclusion that Hasyim’s allegiance to stand on his traditional bases in modernizing his pesantren has created a something useful for directing the orientation and giving the strong foundation of the Indonesia’s Islamic education modernism. His success in harmonizing the elements of modernity with the Islamic traditions under the religious inspection as the pivotal axis is his real contribution to the new madrasah with its own identity to distinct itself with the public school, though the government has “nationalized” the first to be in equivalent to the public school.
Development of Islam In Malaysia
Authors: Nasaruddin R  , Hasaruddin
Published: February 2023

The problems in this research are 1. How is the process of Islamization in Malaysia, 2. How is the development and progress of Islam in Malaysia. The purpose of this research is to find out the process of Islamization in Malaysia and how the progress of Islam in Malaysia develops. It is recorded in history that Islam was evenly embraced by the population in Malaysia in the XII century, coinciding with the arrival of Islam in India and Indochina. Islam entered Malaysia was brought by traders from Arab countries via Malacca which at that time was a trading center, traders stopped at peninsular ports. Since the 1980s, Malaysia has experienced a revival marked by the splendor of da'wah activities and Islamic studies by intellectuals. This research methodology is qualitative and the approach used is literature review which collects data from various sources of papers and books related to the development of Islam in Malaysia. From the research results it was found in recorded history that Islam was evenly embraced by the population in Malaysia in the XII century, coinciding with the arrival of Islam in India and Indochina. Islam entered Malaysia was brought by traders from Arab countries via Malacca which at that time was a trading center, traders stopped at peninsular ports.the development of Islamic progress in Malaysia Since the 1980s, Malaysia has experienced a revival marked by the splendor of da'wah activities and Islamic studies by intellectuals. Religious events as a da'wah process in the spread of Islam in Malaysia, the more widespread the introduction of Islam is further enhanced. Every year this country organizes international activities, namely Musabaqah Tilawatil Quran which is always followed by reciters and qoriah in Indonesia
الأفعال المتعدية في سورة التوبة ( دراسة تحليلية دلالية)
Authors: Rustam
Published: February 2023

The scientific importance of this research is to increase information about the semantic analytical study of the transitive verbs with the prepositional letters. This research uses the qualitative research method, and one of its most important features is that it does not deal with its data through a processing method. It is the qualitative method used by the researcher in this thesis is the descriptive (Description Research). The results of the research in this thesis are as follows: The researcher used a 10-verse model on the transitive verbs themselves in Surat Al-Tawbah. And transitive by other means, the researcher used five formulations: the meaning of addition or expansion is ten verses, the meaning of reduction or narrowing is three verses, the total change in meaning is five verses, the meaning of escalation is two verses, and the meaning changes tocorresponding meanings are two
APPLICATION OF CONCEPT MAPPING TECHNIQUES IN LEARNING TO COMPILE INDUCTIVE PARAGRAPH
Authors: Abdul Azis  , Abd. Rahim
Published: February 2023

The research aimed at the effectiveness of the Concept Map Technique in learning to compose inductive paragraphs for Grade IX SMPIT Al Ishlah Maros students. The research design is experimental. The research population was 54 Class IX students of SMPIT Al Ishlah Maros. A sample of 22 people, namely Class IX-1. carried out by purposive random sampling technique. The research data collection instrument was a test, analyzed using descriptive statistical techniques. The results of this study indicate that TPK is effectively applied in learning to compose inductive paragraphs.
TELAAH METODE PEMBELAJARAN BAHASA ASING DALAM DIMENSI HISTORIS: DARI ERA METODE SAMPAI ERA PASCA METODE
Authors: Hamzah
Published: February 2023

Penelitian ini bertujuan untuk memaparkan dan menelisik metodologi pembelajaran bahasa asing dalam hal ini bahasa Arab dalam dimensi historis epistimologis dari era metode (method era) sampai pada era pasca metode (post method era). Penelitian ini merupakan penelitian kualitatif dengan desain jenis penelitian studi pustaka. pengumpulan datanya lewat dokumentasi yang berasal dari berbagai referensi cetak maupun non cetak, buku, artikel jurnal ilmiah dan bacaan lainnya yang mendukung kajian penelitian ini. Pendekatan yang digunakan adalah pendekatan historis epistimologis yang mencoba menelaah data penelitian secara lahiriyah, dari berbagai asal dan kemungkinannya yang kemudian dianalisis secara ilmiah baik secara induktif, deduktif dan komparatif dalam model interaktif (interractive model). Hasil penelitiannya adalah pembelajaran bahasa Asing dalam hal ini bahasa Arab, meskipun sudah memasuki era pasca metode (post method era) tidak berarti era metode (method era) sudah berakhir dan selesai untuk tidak menggunaka sebuah metode dalam sebuah pembelajaran bahasa. Melainkan,era pasca metode menghendaki seorang pengajar atau pendidik untuk melampaui kemampuan konvensional dan pemahamannya terhadap metodologi pembelajaran bahasa yang sudah banyak dan dipelajari pada era metode. era pasca metode merupakan sintesis dari era sebelumnya. Era pasca metode tidak lagi dituntut menggunakan gaya klasik satu arah dan sesuai untuk semua (direct instruction and one-size-fits-all) melainkan dituntut menyesuaikan tuntutan ke arah keseimbangan baru, tidak lagi berorientasi pada pemenuhan pengetahuan dan kemampuan dasar (knowledge and basic skills) melainkan pengasahan pada keterampilan terapan (applied skills), dan juga dituntut melek TIK dan media (ICT and media litercy skills), berpikir kritis (critical thinking), memecahkan berbagai persoalan (problem-solving skills), dan cakap dalam berkolaborasi (collaborative skills).
Botulinum Toxin Type A for Refractory Neurogenic Detrusor Overactivity in Spinal Cord Injured Patients in Singapore
Authors: Tow Adela M , Toh Khai-Lee , Chan Siew-Pang , Consigliere David
Published: February 2023

Introduction: Managing neurogenic detrusor overactivity (NDO) successfully in spinal cord-injured patients is a challenge. The aims of preserving kidney function by achieving safe bladder pressures with anticholinergic medication often leave a significant proportion of patients with side effects. Botulinum toxin type A has been shown to be a promising alternative.

Materials and Methods: Spinal cord injury patients who had NDO, on clean intermittent self-catheterisation, and were refractory to oral medications, were recruited. Three hundred units of botulinum toxin type A (Botox) in 30 mL NaCl solution were injected under cystoscopic guidance into the bladder.

Results: Fifteen patients were recruited of whom 9 were tetraplegic and 6 were paraplegic. Eleven (73.3%) had complete injuries. There was a significant reduction in the mean number of leakages from 3.75 ± 1.79 pre-injection to 0.67 ± 1.31 and 1.5 ± 1.5 at 6 and 26 weeks post-injection, respectively (P <0.05). Seventy-five per cent, 37.5% and 50% were completely dry at 6, 26 and 39 weeks post-injection, respectively. The mean maximal catheterisable volume increased from 312.3 ± 145.6 mL pre-injection to 484.6 ± 190 mL, 422.3 ± 157.3 mL and 490.0

± 230.4 mL at 6, 26 and 39 weeks post-injection, respectively (P <0.005). Maximum detrusor pressure decreased significantly from 66.3 ± 22.6 cmH2O to 21.2 ± 23.1 cmH2O and 33.6 ± 30.2 cmH2O at 6 and 26 weeks post-injection, respectively (P <0.05). The volume at which reflex detrusor contractions first occurred increased from 127.8 ± 57.5 mL pre-injury to 305.7 ± 130.8 mL at 6 weeks and 288.3 ± 13.0 mL at 26 weeks post-injection (P <0.05). Mean cysometric bladder capacity increased from 187.8 ± 69.2 mL to 305 ± 136.4 mL and 288.3 ± 13.0 mL at 6 and 26 weeks post- injury, respectively (P <0.05). Sixty per cent of patients were completely off medications at 6 and 26 weeks post-injection. One patient had urinary tract infection and 1 experienced autonomic dysreflexia during cystoscopy. Satisfaction levels increased from 4.3 ± 2.3 pre-injury to 7.2 ± 1.9 and 7.3 ± 2.3 at 6 weeks and 26 weeks, respectively. This also correlated with fewer leakages.

Conclusion: Botulinum toxin type A injected into the detrusor is safe and efficacious for spinal cord injured patients with refractory detrusor overactivity. This effect is maintained at 26 weeks post-injection.

Key words: Anticholinergics, Spinal cord injury, Urodynamics, Voiding
A Brief Review of Traumatic Brain Injury Rehabilitation
Authors: Chua Karen SG , Ng Yee-Sien , Yap Samantha GM , Bok Chek-Wai
Published: February 2023

Introduction: This article aims to provide an overview of the epidemiology, medical and rehabilitation issues, current evidence for traumatic brain injury (TBI) rehabilitation, recent advances and emerging practices. Special TBI population groups will also be addressed. Materials and Methods: We included publications indexed in Medline and the Cochrane Database of Systemic Reviews from 1974 to 2006, relevant chapters in major rehabilitation texts and Physical Medicine and Rehabilitation Clinics of North America and accessed Internet publications. Results: TBI has been implicated by the World Health Organisation to be a 21st century epidemic similar to malaria and HIV/AIDS, not restricted to the developed world. One third of patients may suffer severe TBI with long-term cognitive and behavioural disabilities. Injuries to the brain do not only damage the cerebrum but may give rise to a multisystem disorder due to associated injuries in 20% of cases, which can include complex neurological impairments, neuroendocrine and neuromedical complications. There is promising evidence of improved outcome and functional benefits with early induction into a transdisciplinary brain injury rehabilitation programme. However, TBI research is fraught with difficulties because of an intrinsically heterogeneous population due to age, injury severity and type, functional outcome measures and small samples. Recent advances in TBI rehabilitation include task-specific training of cognitive deficits, computer-aided cognitive remediation and visual-spatial and visual scanning techniques and body weight-supported treadmill training for motor deficits. In addition, special rehabilitation issues for mild TBI, TBI-related vegetative states, elderly and young TBI, ethical issues and local data will also be discussed. Key words: Disability, Head injury, Impairment, Neurorehabilitation, Vegetative state
Care of Women in Menopause: Sexual Function, Dysfunction and Therapeutic Modalities
Authors: Mattar Citra Nurfarah , Chong Yap Seng , Su Lin Lin , Agarwal Anupriya Aditya , Wong PC , Choolani Mahesh
Published: February 2023

Introduction: The physiological changes that occur in menopause alter sexual function and affect well-being. Hormonal changes contribute significantly to reduced sexual function in older women and sexual dysfunction may well be amenable to treatment with exogenous hormones or other agents.

Materials and Methods: Relevant clinical studies were identified by a computerised literature search. The collated data were presented to fellow gynaecologists for review, analysis of results and discussion in a series of meetings dedicated to finding the best evidence in menopause management. The evidence was assessed and used to prepare guidelines around the management of women who are affected by sexual dysfunction in menopause.
Results: Hormone therapy benefits many women who have dyspareunia related to vaginal atrophy, reduced libido and decreased satisfaction, particularly if these symptoms adversely affect their quality of life. Alternative agents such as tibolone and sildenafil citrate can be useful adjuncts.
Conclusions: It is increasingly important to recognise postmenopausal sexual dysfunction. Treatment of this syndrome must be individualised to the specific complaints of each woman. Hormones and other agents are relevant treatment options for properly-selected women.

Key words: Androgen, Dyspareunia, Oestrogen, Postmenopause, Sex disorders
Educational Management Action Program for Pre-School
Authors:   Early Childhood Master Program, Lambung Mangkurat University, Indonesia, Lanawaty Rahmawati Ardiyan Armila , Aslamiah Aslamiah , Novitawati Novitawati
Published: February 2023

The purpose of this study aims to describe the strategies used by school principals and educators in group planning, learning management and effective assessment during the pandemic and post-Covid-19 pandemic at the age of 5 to 6 years were applied at TK Al Azhar 037 Banjarbaru and TKIT Robbani Banjarbaru. This study uses a qualitative approach with a multisite method. Collecting data through interviews, observation and documentation. The data processed are from reduction, data display, and conclusion drawing. The results of the study is that educator empowerment strategy was carried out through the involvement of educators in planning, managing, fun-enjoyed, safety and student-friendly learning, and conducting effective assessments. The facility and infrastructure empowerment strategy is carried out through planning, task sharing and setting priority so that the used of media, facilities and infrastructure can be optimally and distributed. Strategies for parent empowerment through parent involvement in parenting, parent-community, and administration of Early Development Screening (DDTK).
The Relationship between Family Smoking Habits and Tuberculosis Incidence in Children Aged 3-6 Years in Bandung Regency
Authors: Tambunan Irisanna , Nanda Shely Novia , Suprapti Tuti
Published: February 2023

Childhood tuberculosis in Indonesia is the third most common in the world, in 2020 the number of new child Tuberculosis cases decreased by 32.4%, this is still far from the government's target in 2024, which is 90%. Bandung Regency has 62 health centers, the highest number of child TB cases is at the Linggar Health Center, namely 42 children with Tuberculosis due to family factors that have smoking habits. The aim of the study was to determine the relationship between family smoking habits and the incidence of Tuberculosis in children aged 3â€“6 years in the Working Area of the Linggar Health Center. This type of research uses casecontrol with a population of 60 families with children aged 3-6 years. The sampling technique used purposive sampling, the sample is 60 families. Data collection using the Riskesdas 2018 questionnaire. Data analysis used univariate and bivariate analysis. The results of the study most of the cases (76.7%) were smokers while the controls (60%) were non-smokers. Family smoking status (P-value 0.004), type of white cigarette (P-value 0.002), number of cigarettes <12 cigarettes (P-value 0.006), duration of smoking > 19 minutes (P-value 0.000), and smoking in the house (P- value 0.001) has a relationship with TB in children. Of the five, smoking duration >19 minutes is the riskiest for TB in children (OR 19,286) because the longer the duration of family smoking, the more influential it is on the incidence of tuberculosis in children aged 3-6 years considering the content of smoking can reduce children's immunity. The conclusion of the study is that there is a relationship between family smoking habits and TB in children aged 3-6 years in the Working Area of the Linggar Health Center.
THE INFLUENCE OF TRANSFORMATIONAL LEADERSHIP STYLE AND EMPLOYEE LOYALTY ON EMPLOYEE PERFORMANCE PT. SMART TALENTA MULTITAMA
Authors: Haryanti Haryanti , Zulganef Zulganef
Published: February 2023

The purpose of this study was to examine the effects of employee loyalty on employee performance as well as the influence of transformational leadership style and employee loyalty on employee performance. At PT Smart Talenta Multitama is a partner organization that provides training, organizational development, legal advice, and human resource management services, a total of 45 employees participated in this quantitative study, all the employees served as respondents, and used of multiple regression in data analysis. According to the regression coefficient value of 0.234 obtained from the results, states that transformational leadership style had a positive and significant impact on employee performance. Employee loyalty also demonstrated a positive and significant impact on employee performance with a regression coefficient value of 0.699, and these results indicate that both transformational leadership style and employee loyalty have an impact on employees' performance.
Application Of Natural Decomposition Method For Solution Of Fractional Black-Scholes Equation
Authors: Bature Sani Sufyan , Sumiati Ira
Published: February 2023

The Black-Scholes equation is a partial differential equation that can model the European call option price problem. This equation can be of the order of natural numbers or fractional. The aim of this paper is to find a solution to the fractional order Black-Scholes partial differential equation. The method used to find solutions to these equations is the Natural decomposition method. Two numerical examples are presented in this paper. The results show that the Natural decomposition method is effective and easy to use to solve the fractional Black-Scholes equation.