bluuebunny/crossref_metadata_2025 huggingface dataset:
Cellular automata in the application to the modeling of traffic flows
Authors: Chechina Antonina Alexandrovna , Churbanova Natalia Gennadievna , Trapeznikova Marina Alexandrovna , Ermakov Alexey Viktorovitch , German Mihail Sergeevich , Lyupa Anastasiya Alexandrovna
Published: January 2023

The preprint summarizes the experience of mathematical modeling of traffic flows on urban road networks using the theory of cellular automata. The proposed multi-lane model allows the description of traffic on complex road networks and takes into account drivers with different lane change strategies. The model is the basis for a set of programs that can be used to obtain various average traffic characteristics, such as, for example, the throughput of an intersection. In addition, the software package allows you to predict the consequences of various decisions regarding changes in the road infrastructure.
Indonesian Capital Market Reaction to Jakarta’s Large Scale Social Restrictions
Authors:   Universitas Sebelas Maret, Indonesia, Wicaksono Nur Catur Wahyu , Aryani Y. Anni , Setiawan Doddy
Published: January 2023

This study aims to analyze the Indonesian capital market reaction to the Large-Scale Social Restrictions (PSBB) policy in Jakarta in 2020. The findings from this study can be used as a policy evaluation and as a reference to assess similar future policies to be implemented in Jakarta. Four event periods were used based on the number of times this policy was implemented in 2020. Using the event study approach and single index model method, this study used 568 companies listed on the IDX which are then divided into nine sectors. The results of this study showed that the Indonesian capital market reacted in different ways following the four periods of PSBB implementation in Jakarta. It was proven that there was no capital market reaction during the first period, a negative reaction for the second period, a positive reaction for the third period, and finally a negative reaction again for the fourth period
Analyzing The Relationship Between Return and Trading Volume in Relation to Cross-Sectional Absolute Deviation (CSAD) In Order to Detect Herding Behavior in Indonesia Emerging Stock Market
Authors:   Universitas Tanjungpura, Indonesia, Malini Helma , Sakliana Annisa Dipa
Published: January 2023

Investor herding behavior is a primary source of speculative bubbles since it implies that investors make identical trading decisions, which can lead to stock prices deviating from their underlying worth. The goal of this study is to detect herding behavior in the Indonesian stock market between 2016 and 2021. The relationship between return and trading volume, known as Cross Sectional Absolute Deviation, is used to assess herding behavior (CSAD). Time-series regression and quantile regression analysis will be employed as data analytic techniques in this study to investigate herding behavior under various market scenarios. Herding behavior is evident in the Indonesian stock market with low trading volume, high market return, and low market return in quantile 0,95. Herd behavior has both beneficial and harmful consequences during certain investing seasons. The best method to reduce the impact is to strengthen the investor’s trading strategy and trading platform
Bank Ownership and Decline in Loan Growth due to the Pandemic
Authors:   Universitas Indonesia, Indonesia, Bitia Ruthana , Dalimunthe Zuliani
Published: January 2023

This study aims to analyze the effect of bank ownership structure on loan growth before and during the pandemic. Specifically, we developed four models to capture different loan types provided in the Indonesian banking system; working capital, investment, consumer, and total loan growth. This study used 150 observations of commercial banks for 2019 (before the pandemic) and 2020 (during the pandemic). We conducted the regression method to test hypotheses. The main finding of this study was that foreign banks’ consumer credit growth significantly lower than domestic banks. Similar findings occurred for other types of loans, and this conclusion has controlled for the adverse effects of the pandemic. This finding means that foreign banks in Indonesia are not substitutes for loan suppliers in the domestic market and tend to behave pro-cyclical. The government needs to carry out regulations to reduce the risk-accelerate nature of foreign banks in the Indonesian economy
EFL STUDENTS’ ENGAGEMENT IN READING COMPREHENSION USING COOPERATIVE INTEGRATED READING AND COMPOSITION (CIRC) TECHNIQUE
Authors: Mahdahera Devianne Dwi Utari , Ridwan Iwan
Published: January 2023

The reading comprehension skills of EFL students have been a concern of scholars by researchers, but some researchers found that EFL students face some problems in understanding English texts due to lack of techniques while teaching. Therefore, this study investigates how students engage in reading comprehension using the Cooperative Integrated Reading Composition Technique. This study uses a case study as a qualitative research design, involving EFL tenth graders from an Islamic Senior High School in Karawang as participants. Researchers collect data through observation and interviews. The findings show that EFL students’ engagement in reading comprehension using the CIRC technique resulted in three engagements, namely behavioral engagement, emotional engagement, and cognitive engagement. Behavioral engagement which means students can contribute to class discussion and follow all instructions from the teacher, emotional engagement which means students can express their feelings during reading comprehension activities, and cognitive engagement which means students can try to complete tasks in different ways to achieve the same result. This research suggests that educators should expand or develop their teaching techniques to produce better learning activities.
PERMASALAHAN SOSIAL DALAM NOVEL AYAT-AYAT CINTA KARYA HABIBURRAHMAN EL SHIRAZY
Authors: Sari Lilis , Rizal Maulfi Syaiful
Published: January 2023

Literary works are the result of imitating or depicting the reality of phenomena that occur in human real life because literary works themselves are a reflection of society. Therefore, literature is an expression of human life that cannot be separated from the problems that exist in society. One of the literary works that express the reality of social life is a novel, one of which is a novel entitled Ayat-Ayat Cinta. This study aims to examine the description of social problems in the novel Ayat-Ayat Cinta by Habiburrahman El Shirazy and find out the driving factors of these social problems. The method used is a descriptive qualitative approach to the sociology of literature. Data was collected using the technique of observing and noting using the observation method. The findings obtained in this study indicate that there are descriptions of social problems in the novel Ayat-Ayat Cinta by Habiburrahman El Shirazy, in the form of discrimination, domestic violence, family disorganization, school bullying, prostitution, polygamy in the western paradigm, and poverty. The various social problems found indicate that factors are driving these social problems in the novel Ayat-Ayat Cinta by Habiburrahman El Shirazy, such as psychological factors and cultural factors
ANALISIS GENRE WACANA SURAT HAMID KEPADA ZAINAB DALAM NOVEL DI BAWAH LINDUNGAN KA’BAH
Authors: Miftah Wangsadanureja  , Juhriati Ika , Muchlisin Muhammad Arif
Published: January 2023

This study will examine the genre analysis of the contents of Hamid's letter to Zainab contained in the novel "Di bawah Lindungan Ka’bah" by Buya Hamka. The subject of this research is Hamid's letters. The object of research is genre. The data obtained is the documentation of their letters contained in the novel. The method used to analyze the data is a qualitative descriptive method. Data analysis uses genre theory because it can conclude the analysis from the types of discourse, as well as describe its substance. The results showed that Hamid's letter to Zainab contained 6 purpose sentences, 1 rhetorical structure. Meanwhile, for the realization of the use of linguistic forms using the LFS (Systemic Functional Linguistics) method, there are data; Mental processes = 9 processes, Material processes = 11 processes, behavioral processes = 2 processes, relational processes = 5 processes. Then after conducting further analysis of this research, we can conclude that Hamid's letter to Zainab belongs to the type of descriptive discourse
SUBORDINASI PEREMPUAN DALAM NOVEL PEREMPUAN YANG MENANGIS KEPADA BULAN HITAM KARYA DIAN PURNOMO
Authors: Alkhaira Nasyadila
Published: January 2023

This article aims to describe the subordination of women in the Novel Perempuan yang Menangis Kepada Bulan Hitam by Dian Purnomo. This research is a qualitative research with a descriptive method and uses a feminist literary approach. The data in this study are in the form of words, phrases, clauses, sentences, and paragraphs that describe the subordination of women in the Novel Perempuan yang Menangis Kepada Bulan Hitam by Dian Purnomo. The results of the study show that subordination to women appears in stories as a result of customary and cultural constraints. Subordination that occurs in the form of women's status is degraded and does not consider women's existence important. Disclosure of women's subordination in the Novel Perempuan yang Menangis Kepada Bulan Hitam will provide information and knowledge for readers to carry out adat in the right way, so that no more women become victims
OVERLAP TYPES IN GOLDEN GLOBE AWARD INTERVIEW BY THE HOLLYWOOD REPORTER
Authors: Denisa Nia , Listiani Toneng , Assiddiqi Hasbi
Published: January 2023

The aim of this research is to categorize what types of overlap are constructed in Golden Globe Award Interview 2020 with Nicholas Braun by The Hollywood Reporter. In an interview, it is one of turn taking violations which still becomes a rife phenomenon where many speakers aren’t aware yet about it. The approach used in this research is descriptive qualitative by documentation technique. The main theory of overlap types is based on Schegloff (2000) and French & Local (1983). There are 13 data found which contain 11 non-competitive: 1 terminal overlap, 5 continuers, 4 conditional access to the turn, 1 choral and 2 competitive: 2 high pitch and increased loudness. So, it can be concluded that the most dominant of overlap type is continuers that categorized as unproblematic for the speakers and conversation structure. Because the next speakers used it to respect the current speakers. Therefore, this result is expected as one of overlap examples which can be applied.
PELESAPAN UNSUR KALIMAT PADA JUDUL BERITA KORAN SOLOPOS EDISI SEPTEMBER 2022
Authors: Nabila Ja’a Nazielatu Rois , Umami Siti Aulia , Sumarlam Sumarlam
Published: January 2023

This research is qualitative research with a discourse analysis approach. The purpose of this study is to describe the elements of sentences contained in news headlines in newspapers. The research data used in the form of written text containing the omission of sentence elements. The source of the research data was obtained through the September 2022 edition of the SOLOPOS newspaper. The data was collected by means of a documentation study using reading and note-taking techniques. This research uses analysis technique of agih and insertion. The results showed that the omission of sentence elements contained in the news title of the September 2022 edition of the SOLOPOS newspaper occurred in two elements, namely the omission of the subject and the verb. The process of removing the title on the news is carried out by writers and editors to adjust the layout of small newspapers and make the news more interesting because it arouses the curiosity of readers. The results of the analysis of 10 news headlines found that there were 1 complete sentence that were not omitted and 9 sentences that were omitted by nouns with subject functions, verbs with predicate functions, and affixes to verbs
ANALISIS KUALITAS TERJEMAHAN PADA LAMAN WEB KBRI BEIJING
Authors: Sofie Sofie , Ayuningtias Niza
Published: January 2023

This study aims to evaluate the accuracy of the Indonesian to Mandarin translation of a web page from the Indonesian Embassy in Beijing. The Nababan translation quality evaluation methodology, which was used in this study, divides translation product quality into three categories: accuracy, acceptability, and readability. This study has two objectives: 1) to analyze the level of accuracy, acceptability and readability of the Indonesian Embassy in Beijing's website and 2) to describe the quality of the translation of the Indonesian Embassy's website in Beijing. The text, which was broken up into 37 pieces of data, was sent to a competent rater to evaluate. The results revealed that the Indonesian Embassy in Beijing's website translation was of lower accuracy, acceptable quality, and had a moderate degree of readability, scoring an overall 2.48 out of 3 for correctness, acceptability, and readability. Although there are certain terms in the target text that require more than one reading to fully get the meaning, the target text is widely accepted and fairly simple for readers who are native speakers of it. It can be concluded that the content of the source text is not conveyed accurately to the target text
The Analysis of Efforts to Prevent Anemia in Pregnant Women during the Covid 19 Pandemic
Authors: Sumailan Gita Patria , Dinengsih Sri , Siauta Jenny
Published: January 2023

Anemia pada ibu hamil masih menjadi masalah global yang menimbulkan dampak bagi ibu dan janin. Anemia pada masa kehamilan dikaitkan dengan angka kesakitan ibu dan penyebab tidak langsung kematian ibu di seluruh populasi ibu hamil. Pada Tahun 2019 di Puskesmas Iwoimendaa Kabupaten Kolaka sebanyak 51,63% ibu hamil mengalami anemia, dan pada tahun 2020 sampai dengan bulan Oktober angka anemia mengalami peningkatan menjadi 62,98%. Semua layanan masyarakat dalam situasi pandemi Covid-19 ini banyak mengalami pembatasan ke termasuk pelayanan kesehatan maternal dan neonatal sehingga resiko meningkatnya angka kejadian anemia pada ibu hamil pada saat pandemic ini. Untuk  mengetahui  upaya pencegahan anemia ibu hamil pada masa pandemi Covid-19 di Puskesmas Iwoimendaa Kabupaten Kolaka.   penelitian  ini  adalah  studi analitik kuantitatif  dengan  pendekatan  Cross  Sectional.  Sampel pada  penelitian  ini  adalah  ibu hamil di Puskesmas Iwoimendaa yang berjumlah 100 orang. Data dianalisis menggunakan uji Chi square. Berdasarkan  hasil  analisis menunjukkan ada hubungan yang signifikan antara upaya pencegahan anemia dengan  gizi (p value = 0,035), pola makan (p value = 0,001), dukungan keluarga (p value = 0,001), kepatuhan konsumsi tablet Fe (p value = 0,029). Variable dominan dengan upaya pencegahan anemia pada masa pandemi covid-19 adalah pengetahuan tentang gizi, pola makan, dukungan keluarga dan kepatuhan konsumsi tablet Fe.   Sebaiknya   petugas Kesehatan dalam masa pandemi covid-19 ini dapat menyusun strategi yang tepat agar ibu hamil dapat mengakses pelayanan antenatal, informasi tentang kesehatan ibu hamil dan pemberian tablet fe.
Aftermarket Wheels Numerical Simulation To Get Maximum Stress and Deformation Values
Authors: Mulyadi Mulyadi , Wijianto Akhmad Surya , Iswanto
Published: January 2023

The purpose of this research is to get wheels with offset variants of -15, +20, and +35 made of aluminum alloy with a maximum load of 690 kg. Autocad 2018 and Unigraphic NX 8 were used to create all three designs. The load was calculated using the SAE J2530 standard and simulated using the ANSYS Workbench 14.5 application's numerical simulation method. As a result, the car rim is designed with a spoke form that becomes steeper (Concave) as the offset decreases. Methods a) Dynamic Cornering Fatigue Test, b) Dynamic Radial Fatigue Test, and c) Impact test consecutively at offset -15 of a) 62.33 MPa, b) 111.61 MPa, and c) 1.58 mm can be used to obtain numerical simulation results. For offsets of +20 of 70.91 MPa, 75.75 MPa, and 1.6 mm. And a) 90.33 MPa, b) 78.13 MPa, c) 1.61 mm at offset +35.
Movement Law of Overlying Strata and Abutment Pressure Redistribution Characteristic Based on Rigid Block
Authors: Yuan Fang , Tang Jianxin , Kong Lingrui
Published: January 2023

Roof movement induced by coal excavation is the immediate cause of rock pressure redistribution and strata behavior. The rigid block in PFC3D was used to generate a multijointed rock mass, and the PFC3D–FLAC3D coupling model was used to study the movement law of the highly developed structural plane of the overlying strata. Strata movement and abutment pressure redistribution characteristics were obtained. The numerical simulation results showed that the multijointed rock mass model reproduced a rock mass with highly developed structural planes. After coal seam mining, the immediate roof caved and filled the goaf, forming an irregular and regular caved zone. The immediate roof shear slipped along the coal wall. The fracture of the basic roof formed a fractured zone, and the maximum height of the fractured zone first increased and then decreased, exhibiting continuous slow subsidence. The fluctuation of the front abutment pressure was reduced, and the abutment pressure in the goaf jumps was discontinuous. The abutment pressure in the goaf was high in the middle and low on both sides. After the initial fracture of the basic roof, the stress concentration of some rock blocks in the goaf exceeded the in-situ stress, and the average abutment pressure increased with the working face advancing length. With the coal wall of the working face gradually moving away from the goaf, the abutment pressure of the goaf first increased and then remained unchanged; the porosity first decreased sharply and then declined slowly; the coordination number of particles rose sharply and then increased slowly, indicating that the goaf gradually stabilized. Similar simulation results indicated that the variation law of abutment pressure, caving characteristics of the immediate roof, and continuous slow subsidence of the basic roof were the same as those of the numerical simulation.
Shear-Wave Splitting Analysis Using Optimization Algorithms
Authors: He Zhengtao , Yang Yuyong , Zhou Huailai
Published: January 2023

Shear-wave splitting (SWS) analysis is used to predict fractures in subsurface media. Specifically, two parameters relevant to SWS analysis (the azimuth of the fast shear wave and the time delay between the fast and slow shear waves) are used to quantify the main azimuth and degree of the fracture development, respectively. However, the algorithms of SWS analysis using a grid search have relatively low computational efficiency, as they need to calculate the objective function values of all grid points. To improve the efficiency of SWS analysis, we proposed new algorithms using the gradient descent, Newton, and advance-retreat methods. The new methods use the direction of the fastest gradient descent, the intersection points of the tangent plane of the first-order objective function with the zero plane, and narrowing the range of extremum points to determine the search path. Therefore, this removes the necessity to compare all grid points in the value region. We compared the three methods and the rotation-correlation method, and both synthetic and field data tests indicated that all three methods had higher computational efficiency than the traditional grid search method. Among the proposed methods, the gradient-descent method obtained the most accurate results for both synthetic and field data. Our study shows that SWS analysis combined with the gradient-descent method can accurately and efficiently obtain SWS parameters for fracture prediction.
Thermal Magnetic Properties Variation of Rock During In-Situ Combustion Process
Authors: Kuzina D. M. , Nurgaliev D. K. , Yuan C. , Morozov V. P. , Varfolomeev M. A. , Utemov E. V. , Chen L. , Pan J. J. , Pu W. F.
Published: January 2023

In-situ combustion (ISC) has been proven as a promising technique for the extraction of heavy oils. It has been used in oil fields since the 1920s; however, it is still not as widely used as steam injection. One of the difficulties limiting its wide application is monitoring and controlling the movement of the combustion front. This work is aimed at studying the change in the properties of rock during the ISC process, which is expected to be used for developing an effective monitoring method of the combustion front movement.

Rock samples before and after the ISC process were obtained from the Xinjiang Oil field (China) where an ISC industrial pilot has been implemented. In the temperature range of lower than 500℃, the minerals may only alter slightly. Therefore, it is difficult to determine whether the rock was heated or not during the ISC processes using general mineralogical or geochemical methods, for example, X-ray diffraction. This work takes a comprehensive approach to study the variation of rock properties. Magnetic analysis was chosen as the primary method since a very tiny change in the mineral composition during heating leads to profound changes in the magnetic properties. We analyzed magnetic susceptibility (MS), natural remanent magnetization (NRM), hysteresis parameters and thermomagnetic data. In addition, we performed differential thermomagnetic analysis (DTMA) for tracing magnetic minerals based on their Curie temperatures as well as for monitoring transformations in magnetic minerals during heating. Simultaneously, X-ray diffractometer (XRD), optical microscope for thin-sections, and organic content measurements were used as assistive methods to get a comprehensive evaluation on the variation of rock.

We found that there is a big difference in magnetic minerals between the initial samples (not subjected to the ISC process) and burned samples from different wells and depths in the ISC pilot. Several magnetic clusters with different coercive force and domain structure were found in these samples. Based on the difference in magnetic properties, we found that the burned samples were heated to different temperatures during the ISC process. In addition, for some rock samples, the heating temperature during the ISC process was determined, and an analysis was made of the propagation of the combustion front.

The thermal magnetic properties variation of rock during the ISC process is obvious, which makes it promising to be used for monitoring the propagation direction of the combustion front. Theoretical calculations of magnetic anomalies that occur due to changes in the magnetic properties of rocks during the ISC process indicate the possibility of the detection of such anomalies from the Earth’s surface through high-precision magnetic surveys. The findings in this work provide a theoretical base and direction for developing combustion front monitoring technologies.
Wrist-ankle acupuncture for the treatment of acute orthopedic pain after surgery: a meta-analysis
Authors: Mengli Chen , Yiyin Xu , Xiuzhen Fu , Jiewei Xie , Xuewei Cao , Yisheng Xu
Published: January 2023

Background：Wrist-ankle acupuncture (WAA) have been reported in treatment of acute pain in orthopedic surgery. However, the effects of WAA on acute pain were controversial in the current studies. Therefore, the purpose of this meta-analysis was to critically evaluate the effects of WAA on acute pain in orthopedic surgery.
Methods: Several digital databases were searched from the inception of databases to July 2021, including CNKI, VIP, Wanfang, CBM, Pubmed, Cochrane Central Register of Controlled Trials, Embase, Medline and Web of Science Core Collection. The risk of bias was evaluated using the cocharne collaboration criteria. The primary outcome indicators included pain score, the dosage of pain killer, analgesia satisfaction, and adverse reaction incidence. All analyses were performed with Review Manager 5.4.1.
Result: A total 10 studies with 725 patients with orthopedic surgery (intervention group: 361, control group: 364) were included in this meta-analysis. The results demonstrated that the pain score of intervention group were lower than the control group, and the difference was statistically significant [MD= -0.29，95%CI(-0.37,-0.21),P<0.0001]. Compared with the control group, the patient in intervention group used smaller amounts of pain killer [MD= -0.16，95%CI(-0.30,-0.02),P=0.02]. the satisfaction of patients on pain relief was also higher in intervention group, and the difference was statistically [OR= 0.25，95%CI(0.15,0.41) , P<0.0001].
Conclusion: WAA has a certain effect on acute pain in orthopedic surgery, and the effect of WAA combined with other therapies is better than that not using WAA therapy.
Identification of Distinct Clinical Phenotypes of Cardiogenic Shock Using Machine Learning Consensus Clustering Approach
Authors: Wang Li , Zhang Yufeng , Yao Renqi , Chen Kai , Xu Qiumeng , Huang Renhong , Mao Zhiguo , Yu Yue
Published: January 2023

Background Cardiogenic shock (CS) is a complex state with many underlying causes and associated outcomes. It is still difficult to differentiate between various CS phenotypes. We investigated if the CS phenotypes with distinctive clinical profiles and prognoses might be found using the machine learning (ML) consensus clustering approach. Methods The current study included patients who were diagnosed with CS at the time of admission from the electronic ICU (eICU) Collaborative Research Database. Among 21,925 patients with CS, an unsupervised ML consensus clustering analysis was conducted. The optimal number of clusters was identified by means of the consensus matrix (CM) heat map, cumulative distribution function (CDF), cluster-consensus plots, and the proportion of ambiguously clustered pairs (PAC) analysis. We calculated the standardized mean difference (SMD) of each variable and used the cutoff of ± 0.3 to identify each cluster’s key features. We examined the relationship between the phenotypes and several clinical endpoints utilizing logistic regression (LR) analysis. Results The consensus cluster analysis identified two clusters (Cluster 1:n = 9,848; Cluster 2:n = 12,077). The key features of patients in Cluster 1, compared with Cluster 2, included: lower blood pressure, lower eGFR (estimated glomerular filtration rate), higher BUN (blood urea nitrogen), higher creatinine, lower albumin, higher potassium, lower bicarbonate, lower red blood cell (RBC), higher red blood cell distribution width (RDW), higher SOFA score, higher APS III score, and higher APACHE IV score on admission. The results of LR analysis showed that the Cluster 2 was associated with lower in-hospital mortality (odds ratio [OR]: 0.374; 95% confidence interval [CI]: 0.347–0.402;P < 0.001), ICU mortality (OR: 0.349; 95% CI: 0.318–0.382;P < 0.001), and the incidence of acute kidney injury (AKI) after admission (OR: 0.478; 95% CI: 0.452–0.505;P < 0.001). Conclusions ML consensus clustering analysis synthesized the pattern of clinical and laboratory data to reveal distinct CS phenotypes with different clinical outcomes.
Leukocyte gene expression predicts human temporal lobe epilepsy seizure frequency
Authors: Sprissler Ryan , Hammer Michael , Labiner David , Joshi Neil , Weinand Maritin
Published: January 2023

Introduction: This study was performed to test the hypothesis that systemic leukocyte gene expression has prognostic value differentiating low from high seizure frequency refractory temporal lobe epilepsy (TLE). Methods: A consecutive series of sixteen patients with refractory temporal lobe epilepsy was studied. Based on a median baseline seizure frequency of 2.0 seizures per month, low versus high seizure frequency was defined as < 2 seizures/month and > 2 seizures/month, respectively. Systemic leukocyte gene expression was analyzed for prognostic value for TLE seizure frequency. All differentially expressed genes were analyzed, with Ingenuity® Pathway Analysis (IPA®) and Reactome, to identify leukocyte gene expression and biological pathways with prognostic value for seizure frequency. Results: There were ten males and six females with a mean age of 39.4 years (range: 16 to 62 years, standard error of mean: 3.6 years). There were five patients in the high and eleven patients in the low seizure frequency cohorts, respectively. Based on a threshold of 2-fold change (p < 0.001, FC > 2.0, FDR < 0.05) and expression within at least two pathways from both Reactome and Ingenuity® Pathway Analysis (IPA®), 13 differentially expressed leukocyte genes were identified which were all over-expressed in the low when compared to the high seizure frequency groups, including NCF2, HMOX1, RHOB, FCGR2A, PRKCD, RAC2, TLR1, CHP1, TNFRSF1A, IFNGR1, LYN, MYD88, and CASP1. Similar analysis identified four differentially expressed genes which were all over-expressed in the high when compared to the low seizure frequency groups, including AK1, F2R, GNB5, and TYMS. Conclusions: Low and high seizure frequency TLE are predicted by the respective upregulation and downregulation of specific leukocyte genes involved in canonical pathways of neuroinflammation, oxidative stress and lipid peroxidation, GABA (γ-aminobutyric acid) inhibition, and AMPA and NMDA receptor signaling. Furthermore, high seizure frequency-TLE is distinguished prognostically from low seizure frequency-TLE by differentially increased specific leukocyte gene expression involved in GABA inhibition and NMDA receptor signaling. High and low seizure frequency patients appear to represent two mechanistically different forms of temporal lobe epilepsy based on leukocyte gene expression.
In Vitro Evaluation of Anticoagulant Therapy Management when Urgent Percutaneous Coronary Intervention is Required in Rivaroxaban-Treated Patients
Authors: MELEK Mehmet , ARI Hasan , ARI Selma , CILGIN Mehmet Can , YARAR Mücahit , HUYSAL Kagan , AGCA Fahriye VATANSEVER , BOZAT Tahsin
Published: January 2023

Objectives: We investigated in vitro the management of intraprocedural anticoagulation in patients requiring immediate percutaneous coronary intervention (PCI) while using regular direct oral anticoagulants (DOACs).
Materials and methods: Twenty-five patients taking 20mg of rivaroxaban once daily comprised the study group, while five healthy volunteers included the control group. In the study group, a beginning (24 hours after the last rivaroxaban dose) examination was performed. Then, the effects of basal and four different anticoagulant doses (50 IU/kg unfractionated heparin (UFH), 100 IU/kg UFH, 0.5 mg/kg enoxaparin, and 1 mg/kg enoxaparin) on coagulation parameters were investigated at the 4th and 12th hours following rivaroxaban intake. The effects of four different anticoagulant doses were evaluated in the control group. The anticoagulant activity was assessed mainly by anti-factor Xa (anti-Xa) levels.
Results: Beginning anti-Xa levels were significantly higher in the study group than in the control group (0.69±0.77 IU/mL vs. 0.20±0.14 IU/mL; p <0.05). The study group's 4th and 12th-hour anti-Xa levels were significantly higher than the beginning level (1.96±1.35 IU/mL vs. 0.69±0.77 IU/mL; p <0.001 and 0.94±1.21 IU/mL vs. 0.69±0.77 IU/mL; p <0.05, respectively). Anti-Xa levels increased significantly in the study group with the addition of UFH and enoxaparin doses at the 4th and 12th hour than the beginning (p <0.001 at all doses). The safest anti-Xa level (from 0.94±1.21 IU/mL to 2.00±1.02 IU/mL) was achieved 12 hours after rivaroxaban with 0.5mg/kg enoxaparin.
Conclusion: Anticoagulant activity was sufficient for urgent PCI at the 4th hour after rivaroxaban treatment, and additional anticoagulant administration may not be required at this time. Twelve hours after taking rivaroxaban, administering 0.5mg/kg of enoxaparin may provide adequate and safe anticoagulant activity for immediate PCI. This experimental study result should confirm with clinical trials (NCT05541757).
Adaptation of a model for integration of interventions for alcohol use disorder in primary health care in Tanzania
Authors: Mushi Dorothy , Hanlon Charlotte , Francis Joel M , Candida Moshiro , Demissie Mekdes , Teferra Solomon
Published: January 2023

Integrating evidence-based interventions for people with alcohol use disorder (AUD) into primary healthcare (PHC) can increase access to care and reduce morbidity, mortality, and population burden. However, for the integration to be feasible, acceptable, and sustainable, there is a need to contextualize the approach and involve stakeholders. Therefore, this study aimed to use participatory methods to adapt a model for integrating AUD interventions in Tanzania’s PHC system at the community, facility, and organizational levels.
Methods
A mixed-methods study was used. Participants include key mental health stakeholders, experts, and PHC providers. We conducted a situational analysis to investigate opportunities and constraints in the existing systems of care, utilizing data available from the routine collection and/or in the public domain; individual semi-structured interviews (n=11), and focus group discussions (3 groups; total n=26 participants) and a series of theory of change (ToC) workshops (n=32). Data from the three methods were triangulated to develop the adapted model for integrating interventions for AUD in PHC.
Results
The consensus long-term outcome of the Theory of Change map is to improve the physical, mental health, and social well-being of people treated for AUD to increase productivity in the community. Necessaryinterventions for the community were identified as awareness-raising, improving access to care, community engagement, and resource mobilization. Facility interventions included capacity building to strengthen staff competencies and supportive supervision. Organizational level interventions included strengthening infrastructure for the mental health service delivery system and financing. Identified facilitators for implementing the intervention packages were leveraging existing health system resources and recognizing that mental health was part of PHC. Potential barriers included an under-resourced health system, reflected in an inadequate number of HCPs in the community and facility and inadequate prioritization of mental health care.
Conclusions
The intervention packages for an adapted model for integrating AUD interventions in PHC in Tanzania have been identified, as well as their potential barriers and facilitators to the feasibility of implementation. There is a need to pilot the adapted model to inform plans for wider implementation or scaling up.
Diabetes mellitus affects the treatment outcomes of drug-resistant tuberculosis: A systematic review and meta-analysis
Authors: Xu Guisheng , Hu Xiaojiang , Lian Yanshu , Li Xiuting
Published: January 2023

Background
Both tuberculosis (TB) and diabetes mellitus (DM) are major public health problems threatening global health. Drug-resistant TB (DR-TB) and impaired immunity caused by DM make controlling TB more difficult.
Methods
We searched PubMed, Excerpta Medica Database (EMBASE), Web of Science, ScienceDirect and Cochrance Library for literature published in English until July 2022. Papers were limited to those reporting the association between DM and treatment outcomes among DR-TB and multidrug-resistant TB (MDR-TB) patients. The strength of association was presented as odds ratios (ORs) and their 95% confidence intervals (CIs) using the fixed-effects or random-effects models. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) were followed for the analysis.
Results
A total of twenty-five studies involving 16,905 DR-TB patients were included in the meta-analysis, of which 10,124 (59.88%) participants were MDR-TB patients, and 1,952 (11.54%) had DM history. In DR-TB patients, the pooled OR was 1.56 (95% Cl: 1.24–1.96) for unsuccessful outcomes, 0.64 (95% Cl: 0.44–0.94) for cured treatment outcomes, 0.63 (95% Cl: 0.46–0.86) for completed treatment, and 1.28 (95% Cl: 1.03–1.58) for treatment failure. Among MDR-TB patients, the pooled OR was 1.57 (95% Cl: 1.20–2.04) for unsuccessful treatment outcomes, 0.55 (95% Cl: 0.35–0.87) for cured treatment outcomes, 0.66 (95% Cl: 0.46–0.93) for completed treatment and 1.37 (95% Cl: 1.08–1.75) for treatment failure.
Conclusion
DM is a risk factor for adverse outcomes of DR-TB or MDR-TB patients. Controlling hyperglycemia may contribute to the favourable prognosis of TB.
Efficacy of Cassava Starch in the Design of Drug Delivery Platforms: From Roots to Polymers
Authors: Das Sanjoy , Bhattacharya Bireswar , Jamatia Taison , Sinha Bibek , Das Biplajit , Mazumder Rishav , Daule Ichu , Paul Kishan , Roy Ankita , Choudhury Ankita , Sadhukhan Pinkan , Sarmah Dibyojyoti , Bhargab Dhritiman , Jana Bani Kumar , Bishwas Nayan Ranjan Ghose , Tayeng Dubom , Yadav Pradip Kumar
Published: January 2023

Starch has cropped up as a new attractive biopolymer for use in pharmaceutical applications, owing to its distinctive physical, chemical and functional properties. This biopolymer has a number of potential advantages like being biocompatible, low cost, easily isolated from plant sources and non-toxic in nature. In the field of pharmaceutical science, starch is used as a raw material for the development of various drug delivery platforms. Generally, cassava starch (tapioca) is obtained from swollen roots of the perennial shrub Manihot esculenta and it contains a low amount of amylose in contrast to other varieties of starches. Because of this reason, cassava starch exhibits various prime benefits including little gelatinization temperature, higher swelling power and produces relatively high viscosity paste, making it preferable as an excipient for pharmaceutical applications. However, cassava starches in their native form are offensive for many applications due to their inefficiency to withstand various processing requirements like high temperature and diverse pH, but their use is enhanced by starch modification. These functional starches have demonstrated outstanding potential as primary excipients in a number of pharmaceutical formulations. In this article, we discuss the potential application of cassava starches in the pharmaceutical and biomedical fields along with the toxicity assessment of modified cassava starches.
Therapeutic potential of oxymatrine in impeding the cardiomyopathy in the STZ- nicotinamide induced diabetes through SIRT1/Nrf2 signaling activation
Authors: Seksaria Sanket , Mehan Sidharth , Dutta Bhaskar Jyoti , Gupta Ghanshyam Das , Singh Amrita
Published: January 2023

Aims
Diabetes mellitus increases the risk of heart failure independently of underlying hypertention and ischemic heart disease, leads to the cardiomyopathy. Molecular mechanism underlying these pathological changes in the diabetic cardiomyopathy (DCM) are most likely to multifactorial, but clearer pathogenesis is partially understood. Literature showed that insulin resistance was associated with the dysfunction of SIRT1, TGF-β1 protein expression and pro-apoptotic pathways. In the current research, we aimed to investigate the ameliorative effect of oxymatrine (OMT) against streptozotocin-nicotinamide (STZ-NA) induced DCM in the experimental animals.
Method
Male wistar rats (120–150 g) were pre-treated with the NA (110 mg/kg, i.p) followed by administration of STZ (60 mg/kg, i.p) after 15 min. After observed the onset of cardiomyopathy evaluated by increased diastolic dysfunction followed by systolic, two weeks later of STZ-NA administration, animals were divided in to various treatment groups. Diabetic animals were treated with pioglitazone (10mg/kg, p.o) and OMT(25, 100, 150 mg/kg, i.p) for 3 weeks. Various biochemical parameters were checked after completion of the experimental protocol.
Key findings:
Diabetic animals showed hyperglycemia, impaired glucose tolerance and lipid profile. In addition, increased blood pressure, serum LDH, CK-MB levels, and abnormal hemodynamic. Apart from this, pro-inflammatory cytokines, apoptotic markers, TGF-β1 activity were increased and SIRT1 activity was decreased in thediabetic animals. While, treatment with the OMT, restored all these abnormalities. Additionally, OMT treatment dose dependently restored the anti-oxidants, pro-inflammatory, and apoptotic marker. On the basis of these observations, we concluded that OMT can protect diabetic rats from insulin resistance through the regulation of SIRT1/Nrf2, TGF-β1 and pro-apoptotic pathways.
Identification of line-source transfer mobility and force density by ground acceleration measurements
Authors: Tao Zi-Yu , Wang Yi-Min , He Wei , Luo Yun-Ke
Published: January 2023

Ground-borne vibration caused by railway traffic has been a research concern due to its possible side effects on nearby residences. The force density and line-source mobility can effectively characterize the generation and transmission of train-induced vibrations, respectively. This research proposed a frequency-domain method for identifying the line-source mobility and force density using measured vibrations at the ground surface. It was achieved by minimizing the difference of force densities formulated using measurements at two different locations, in which the genetic algorithm was adopted for solving the optimization problem. The proposed method was later applied to and validated by a case study at Shenzhen Metro in China, where a total of seven fixed-point hammer impacts with 3.3 m equal intervals were used to represent the vibration excitation from one vehicle. The fixed-point loads' assumption was validated by comparing the identifications with the predictions based on the train-track coupled dynamic model and theoretical derivation. Causes for different dominant frequencies can be traced by separating the dynamic characteristics of vibration excitation and transmission. It was found in the case study that at a location 3 m away from the track, the peak at 50 Hz was caused by excitations, while that at 63 Hz was attributed to transmission efficiency related to the soil properties. Finally, the identified line-source transfer mobility and force density levels were applied to the forward problem of making predictions. The predicted ground vibrations at different locations were compared to field measurements, with good agreement, which experimentally validated the identification method. The identification results of the case study can be employed by similar railway systems as a good reference.
ATAT: Astronomical Transformer for time series And Tabular data
Authors: Astorga Nicolás , Reyes Ignacio , Cabrera Guillermo , Förster Francisco , Huijse Pablo , Arredondo Javier , Moreno-Cartagena Daniel , Muñoz-Arancibia Alejandra , Bayo Amelia , Catelan Marcio , Estevez Pablo , Sanchez-Saez Paula , Álvarez Alex , Castellanos Pablo , Gallardo Pedro , Moya Alberto , Rodriguez-Mancini Diego
Published: January 2023

We present ATAT, the Astronomical Transformer for time series And Tabular data, a classification model that receives as input both light-curves and tabular data from astronomical sources. ATAT consists of a light-curve Transformer with a new time modulation that encodes the time of each observation, and a feature Transformer that uses a Quantile Feature Tokenizer. This model was conceived by the ALeRCE alert broker in the context of the recent Extended LSST Astronomical Time-Series Classification Challenge (ELAsTiCC). ATAT outperforms previous decision tree-based ensemble approaches in terms of classification when trained over the ELAsTiCC dataset. Importantly, some of its variants do not require human-engineered features, with significantly reduced inference computational times (400x faster). The use of Transformer multimodal architectures, combining light-curve and tabular data, opens new possibilities for classifying alerts from a new generation of large etendue telescopes, such as the Vera C. Rubin Observatory, in real-world brokering scenarios.
WITHDRAWN: Measurement of the Casimir force with a natural renormalization and a maximum vacuum frequency
Authors: Kulas Sascha
Published: January 2023

The Casimir force pushes two plates together in vacuum. This force still has a lot of unknown aspects. We measure the Casimir force in a tuning fork experiment with an additional metal plate. By changing the plates spacing we show that the amplitude of the Casimir force can be shifted. Moreover, we measure that the vacuum fluctuations which produce this effect are damped, with a minimum wavelength of around 0.17 mm. This behaviour acts as a natural renormalization. The maximum frequency of 1.76 THz would have an extensive impact. The cosmological constant problem would be strongly reduced because the vacuum energy density would have the same order than measured by cosmological constant experiments, instead of 120 orders.
Bacteroides uniformis regulates TH17 cell differentiation and alleviates chronic colitis by producing alpha-muricholic acid
Authors: Zhang Enping , Yan Yiting , Lei Yu , Qu Ying , Fan Zhen , Zhang Ting , Xu Yangbin , Du Qian , Brugger Daniel , Chen Yulin , Zhang Ke
Published: January 2023

Inflammatory bowel disease (IBD) cause colitis-associated malignancy. Studies have shown that IBD development is associated with dysbiosis of the gut microbiota using the IBD model of animals and humans.Bacteroides uniformis, the most abundant core strain in mammals, regulates animal intestinal homoeostasis. However, the key metabolic compounds and mechanism by whichB. uniformistreats colitis in mice are unknown. In this study,B. uniformisJCM5828-gavaged female C57BL/6 mice (n = 8) greatly alleviated the progression of DSS-induced colitisand restored the expression of mechanical and immune barrier proteins in the colon. Furthermore, increased abundance ofB. uniformisin the colon promoted the abundance of the symbiotic bacteriaBifidobacteriumandLactobacillus vaginalisand inhibited the ecological niche of pathogenicEscherichia coli, thus regulating intestinal lipid metabolism function. Specifically,B. uniformissignificantly increased the synthesis of primary and secondary bile acids (alpha-Muricholic acid (α-MCA), Isochenodeoxycholic acid (isoCDCA), hyodeoxycholic acid (HDCA), and isolithocholic acid (isoLCA)) in the colonic contents.B. uniformisalso significantly regulated the expression of key regulator genes and proteins of the NF-κB and MAPK signaling pathways in colonic tissues and inhibited TH17 differentiation.In vitrocellular validation showed that singleB. uniformiscould not significantly inhibit TH17 differentiation in T lymphocytes. In contrast, key metabolic molecules α-MCA, HDCA and isoLCA could inhibit TH17 differentiation in the lamina propria and regulate the intestinal immune response. Cumulatively, the results indicate thatB. uniformisJCM5828 supplementation may be an optional approach to the treat colitis and other diseases associated with intestinal barrier dysfunction.
Multi-layered epigenetic control of persistent and stage-specific imprinted genes in rice endosperm
Authors: Tonosaki Kaoru , Ono Akemi , Nagata Hiroki , Furuumi Hiroyasu , Nonomura Ken-ichi , Sato Yutaka , Comai Luca , Hatakeyama Katsunori , Kawakatsu Taiji , Kinoshita Tetsu
Published: January 2023

In the offspring, imprinted genes show differential expression from the maternal and paternal alleles. Our time-course analysis in rice (Oryza sativa) revealed persistent and stage-specific classes of imprinted genes, including over a hundred novel genes, especially in the early stage of endosperm development. In the persistent maternally expressed genes (MEGs), CG and CHG sequences are heavily methylated, while these sites are less methylated in the stage-specific MEGs. Similarly, differences in H3K27me3 defined the two classes of paternally expressed genes (PEGs). The imprinting for MEGs involves activating silent genes. By contrast, many PEGs are active in various tissues and carry gene body DNA methylation (gbM); the maternally inherited alleles of these PEGs undergo silencing via gbM demethylation and deposition of H3K27me3. Stage-specific imprinting indicates that parental marks can be differentially interpreted during development. Its developmental variability contrasts the robustness of persistent imprinting, revealing the dynamic layering of parental effects and suggesting new mechanisms for evolution and manipulation of rice endosperm development.