bluuebunny/crossref_metadata_2025 huggingface dataset:
The optimal oxytocin infusion rate for preventing uterine atony during cesarean delivery in elderly parturients with prior history of cesarean delivery
Authors: Wang Li Ying , Wang Jin , Dong Jin Hua , Ping Ze Peng , Chen Xin Zhong , Wei Chang Na
Published: July 2023

Background: An estimate of 90% effective dose (ED90) of oxytocin infusion has already been proved effective in non-laboring parturients. However, the requirements of oxytocin for elderly parturients with prior history of cesarean delivery (CD) may be higher. The aim of this study was to find the optimum oxytocin infusion rate for preventing uterine atony during CD in elderly parturients with prior history of CD.

Method: We performed a randomized, double-blinded study in 120 healthy elderly parturients with prior history of CD scheduled for elective CD under combined spinal–epidural (CSE) anesthesia. Participants were treated with oxytocin infusion randomly at the rates of 0, 4, 8, 12, 16, or 20 IU h−1 after the delivery of infants. Following oxytocin administration, a blinded obstetrician evaluated the uterine tone (UT), verbally describing it using numerical scales (0–10: 0, no UT; 10, optimal UT) as either adequate or inadequate at the time intervals of 3, 6, and 9 min. Maternal adverse effects, requirements for additional uterotonic agents, delivery–placenta delivery time (PD), and estimated blood loss (EBL) were recorded.

Results: The 50% effective dose (ED50) and 90% effective dose (ED90) of oxytocin infusion were 14.6 IU h−1 (95% confidence interval 12.0–18.4 IU h−1) and 27.7 IU h−1 (95% confidence interval 22.5–39.4 IU h−1), respectively. As the rate of infusion was increased in parturients, the rescue oxytocin dose and delivery-PD time were decreased. Parturients who received 0 IU h−1 oxytocin at 3, 6, and 9 min obtained lower UT scores than those who received 16 and 20 IU h−1 oxytocin (p < 0.05, respectively). No significant differences were observed among groups in EBL and maternal adverse effects.

Conclusion: The infusion rate of oxytocin at 14.57 and 27.74 IU h−1 produces adequate UT in 50% and 90% of elderly parturients with prior history of CD, respectively. An oxytocin infusion rate of 27.7 IU h−1 is suggested to be the optimal dose for preventing uterine atony during CD in elderly parturients with prior history of cesarean delivery.

Clinical Trial Registration: [https://www.chictr.org.cn/bin/project/edit?pid=62489], Identifier: [ChiCTR2000038891].
Darovasertib, a novel treatment for metastatic uveal melanoma
Authors: Cao Lei , Chen Shuzhen , Sun Rainie , Ashby Charles R. , Wei Liuya , Huang Zoufang , Chen Zhe-Sheng
Published: July 2023

The FDA granted orphan drug designation to darovasertib, a first-in-class oral, small molecular inhibitor of protein kinase C (PKC), for the treatment of uveal melanoma, on 2 May 2022. Primary uveal melanoma has a high risk of progressing to metastatic uveal melanoma, with a poor prognosis. The activation of the PKC and mitogen-activated protein kinase pathways play an essential role in the pathogenesis of uveal melanoma, and mutations in the G protein subunit alpha q (GNAQ), and G protein subunit alpha11 (GNA11) genes are considered early events in the development of uveal melanoma. Compared to other PKC inhibitors, such as sotrastaurin and enzastaurin, darovasertib is significantly more potent in inhibiting conventional (α, β) and novel (δ, ϵ, η, θ) PKC proteins and has a better tolerability and safety profile. Current Phase I/II clinical trials indicated that darovasertib, combined with the Mitogen-activated protein kinase/Extracellular (MEK) inhibitors, binimetinib or crizotinib, produced a synergistic effect of uveal melanoma. In this article, we summarize the development of drugs for treating uveal melanomas and discuss problems associated with current treatments. We also discuss the mechanism of action, pharmacokinetic profile, adverse effects, and clinical trial for darovasertib, and future research directions for treating uveal melanoma.
Effect of physical activity on attention in school-age children with ADHD: a systematic review and meta-analysis of randomized controlled trials
Authors: Li Dong , Li Lan , Zang Wanli , Wang Deng , Miao Chuyuan , Li Chenmu , Zhou Li , Yan Jin
Published: July 2023

Background: Attention problems are one of the core symptoms of Attention-deficit/hyperactivity disorder (ADHD) in children. Previous studies have shown that physical activity intervention has a positive impact on executive function in children and adolescents with ADHD, but there is limited research on attention problems in school-aged children with ADHD. There are still uncertainties about the appropriate physical activity interventions to improve attention problems in this population. This study conducted a Meta-analysis of randomized controlled trials (RCTs) related to physical activity intervention for attention problems in school-aged children with ADHD, providing a certain reference for precise intervention in attention problems for this population.

Methods: We systematically searched the following databases up to October 2022: PubMed, Embase, Web of Science, and Cochrane Library, to identify RCTs that investigated the effects of physical activity interventions on children with ADHD. Two investigators independently conducted literature screening, extraction, and quality assessment. We performed a meta-analysis using Stata 15.1.

Results: In total, we included 10 studies in this meta-analysis. The results indicated that physical activity intervention had a moderate effect in improving attention problems in school-aged children with ADHD (SMD = −0.48, 95% CI: 0.85, −0.07, p < 0.05). Furthermore, subgroup analysis showed that the effect of physical activity intervention was moderated by intervention type, frequency, and period, rather than the physical activity environment or single intervention time.

Conclusion: Our study suggests that cognitively engaging exercise is more effective in improving attention problems in school-aged children with ADHD. Specifically, when cognitive-engaging exercise is used as the type of physical activity and the intervention frequency is less than 3 times per week, with an intervention period of less than weeks, it is most beneficial for improving attention problems in school-aged children with ADHD. However, we should also consider individual differences in children with respect to their ADHD symptoms and accurately evaluate each child’s specific symptoms before intervention.

Systematic Review Registration: identifier (CRD42022363255).
Effects of nitrogen fertilization and a commercial arbuscular mycorrhizal fungal inoculant on root rot and agronomic production of pea and lentil crops
Authors: Hubbard Michelle , Thomson Madeleine , Menun Alexander , May William E. , Peng Gary , Bainard Luke D.
Published: July 2023

In the Canadian prairies, pulse crops such as field pea (Pisum sativum L.) and lentil (Lens culinaris L.) are economically important and widely grown. However, in recent years, root rot, caused by a variety of fungal and oomycete pathogens, including Aphanomyces euteiches, has become a limiting factor on yield. In this study, we examined the impacts of nitrogen (N) fertilization and a commercial arbuscular mycorrhizal fungal (AMF) inoculant on pea and lentil plant health and agronomic production at three locations in Saskatchewan: Swift Current, Indian Head and Melfort. The AMF inoculation had no impact on root rot severity, and therefore is not considered a reliable method to manage root rot in pea and lentil. In contrast, N fertilization led to reductions in root rot in Swift Current, but not the other two sites. However, N fertilization did reduce nodulation. When both pea and lentil are considered, the abundance of A. euteiches in soil increased from pre-seeding to mid-bloom. A negative correlation between soil pH and disease severity was also observed. The high between-site variability highlights the importance of testing root rot mitigation strategies under multiple soil conditions to develop site-specific recommendations. Use of N fertilizer as a root rot management strategy merits further exploration, including investigation into its interactions with other management strategies, soil properties, and costs and benefits.
A fine recognition method of strawberry ripeness combining Mask R-CNN and region segmentation
Authors: Tang Can , Chen Du , Wang Xin , Ni Xindong , Liu Yehong , Liu Yihao , Mao Xu , Wang Shumao
Published: July 2023

As a fruit with high economic value, strawberry has a short ripeness period, and harvesting at an incorrect time will seriously affect the quality of strawberries, thereby reducing economic benefits. Therefore, the timing of its harvesting is very demanding. A fine ripeness recognition can provide more accurate crop information, and guide strawberry harvest management more timely and effectively. This study proposes a fine recognition method for field strawberry ripeness that combines deep learning and image processing. The method is divided into three stages: In the first stage, self-calibrated convolutions are added to the Mask R-CNN backbone network to improve the model performance, and then the model is used to extract the strawberry target in the image. In the second stage, the strawberry target is divided into four sub-regions by region segmentation method, and the color feature values of B, G, L, a and S channels are extracted for each sub-region. In the third stage, the strawberry ripeness is classified according to the color feature values and the results are visualized. Experimental results show that with the incorporation of self-calibrated convolutions into the Mask R-CNN, the model’s performance has been substantially enhanced, leading to increased robustness against diverse occlusion interferences. As a result, the final average precision (AP) has improved to 0.937, representing a significant increase of 0.039 compared to the previous version. The strawberry ripeness classification effect is the best on the SVM classifier, and the accuracy under the combined channel BGLaS reaches 0.866. The classification results are better than common manual feature extraction methods and AlexNet, ResNet18 models. In order to clarify the role of the region segmentation method, the contribution of different sub-regions to each ripeness is also explored. The comprehensive results demonstrate that the proposed method enables the evaluation of six distinct ripeness levels of strawberries in the complex field environment. This method can provide accurate decision support for strawberry refined planting management.
Testing the somatic marker hypothesis in decisions-from-experience with non-stationary outcome probabilities
Authors: Wright Rebecca J. , Rakow Tim
Published: July 2023

Introduction

The Somatic Marker Hypothesis (SMH) posits that in experience-based choice, people develop physiological reactions that mark options as either positive or negative. These somatic markers aid decision making because they differentiate between “good” and “bad” options during pre-choice deliberation.

Methods

We examined this proposed role for somatic states in two decision-from-experience tasks (each N = 36) in which participants selected repeatedly with full feedback (i.e., for obtained and forgone outcomes) between two unlabeled options that returned wins or losses, with half receiving an additional summary of past outcomes. The probabilities of good and bad outcomes changed at an unannounced point. Participants completed a 100-trial game with a switch in the optimal option after trial 40 (Study 1) or a 200-trial game with switch points after trial 40 and trial 120 (Study 2). Skin conductance (SC) was measured continuously as an index of emotional intensity, from which we extracted measures of anticipatory SC (pre-choice) and outcome SC (post-choice).

Results

Participants reliably selected the optimal option prior to any switches. They also altered their choices appropriately when the payoffs changed, though optimal play following payoff switches was reduced. Losses resulted in a greater outcome SC than wins, but only in Study 1, as did the finding that the outcome SC was greater when the forgone outcome was positive. Anticipatory SC did not reliably predict optimal play in either study.

Discussion

These results provide little support for the SMH. Our studies point to the importance of using diverse tasks and measures and very large sample sizes when testing the role of somatic states in decision making.
Association between triglyceride glucose index and suicide attempts in patients with first-episode drug-naïve major depressive disorder
Authors: Liu Junjun , Zhu Xiaomin , Liu Yang , Jia Fengnan , Yuan Hsinsung , Wang Qingyuan , Zhang Xiaobin , Li Zhe , Du Xiangdong , Zhang Xiangyang
Published: July 2023

Objective

Triglyceride glucose (TyG) index has been suggested as an alternative indicator of insulin resistance (IR); however, the association between TyG index and suicide attempts (SA) in major depressive disorder (MDD) is unclear. The aim of this study was to investigate the relationship between TyG index and SA in Chinese patients with first-episode drug-naïve (FEDN) MDD.

Methods

This cross-sectional study enrolled 1,718 patients with FEDN MDD aged 34.9 ± 12.4 years from the First Hospital of Shanxi Medical University (Taiyuan, Shanxi Province, China) from September 2016 to December 2018. Multivariable binary logistic regression analysis was used to estimate the association between TyG index and the risk of SA. A two-piecewise linear regression model was used to investigate the threshold effects if non-linearity associations existed. Interaction and stratified analyses were performed based on sex, education, marital status, comorbid anxiety, and psychotic symptoms.

Results

Multivariable logistic regression analysis revealed that TyG index was positively associated with the risk of SA after adjusting for confounders (OR = 1.35, 95% CI: 1.04–1.75, p = 0.03). Smoothing plots also showed a nonlinear relationship between TyG index and SA, with the inflection point of TyG index being 9.29. On the right of the inflection point, a positive association between TyG index and SA was detected (OR = 3.47, 95% CI: 1.81 to 6.66, p < 0.001), while no significant association was observed on the left side of the inflection point (OR = 1.14, 95% CI: 0.79 to 1.66, p = 0.476).

Conclusion

The relationship between TyG index and SA risk was non-linear and exhibited a threshold effect in Chinese patients with FEDN MDD. When TyG index was greater than 9.29, they showed a significant positive correlation.
The gap in capacity building on climate, health, and equity in built environment postsecondary education: a mixed-methods study
Authors: Houghton Adele
Published: July 2023

Institutions of higher education are feeling increasing pressure from both students and the international climate community to offer more courses and joint degrees on the role of the built environment in advancing climate action, population health, and social equity. The built environment plays a leading role in this new, transdisciplinary approach. Thoughtfully designed buildings, neighborhoods, and communities can simultaneously lower per capita greenhouse gas emissions, reduce population exposure to dangerous climate-sensitive extreme weather events, reduce disparities in climate-related health outcomes, and advance social equity goals. This mixed-methods study explored the extent to which post-secondary courses and joint degree programs teach students the research methods and technical skills they will need to design and implement built environment interventions addressing the effects of climate change on population health and social equity. The study found that the number of universities offering courses addressing climate, health, and equity in the built environment grew from 2018 to 2022. The number of joint planning/public health degree programs rose from four in 2005 to 15 in 2022. No joint architecture/public health degree programs were identified. A detailed review of 99 course descriptions from three universities found that 17 courses (roughly 1/5 of the total) covered population health, built environment, and climate change; and, 2/3 of the set (n = 60) covered two out of the three topics. Schools of public health were more likely to offer courses covering all three topics, whereas schools of architecture were more likely to include the building scale in relevant courses. Exposure pathways and social equity/vulnerable populations were the most common methods included in relevant courses. Professors and administrators at institutions identified by the study as “transdisciplinary-ready” reported that accreditation requirements and university rules governing the allocation of student tuition had slowed efforts to offer cross-listed courses. However, faculty in these institutions regularly collaborate informally with their peers – both on transdisciplinary research and by offering guest lectures in each other’s courses. The results of this study show that, while universities have made great strides over the past 18 years in beginning to support transdisciplinary research and pedagogy, institutional barriers and gaps in key content areas remain.
The potential of robot eyes as predictive cues in HRI—an eye-tracking study
Authors: Onnasch Linda , Schweidler Paul , Schmidt Helena
Published: July 2023

Robots currently provide only a limited amount of information about their future movements to human collaborators. In human interaction, communication through gaze can be helpful by intuitively directing attention to specific targets. Whether and how this mechanism could benefit the interaction with robots and how a design of predictive robot eyes in general should look like is not well understood. In a between-subjects design, four different types of eyes were therefore compared with regard to their attention directing potential: a pair of arrows, human eyes, and two anthropomorphic robot eye designs. For this purpose, 39 subjects performed a novel, screen-based gaze cueing task in the laboratory. Participants’ attention was measured using manual responses and eye-tracking. Information on the perception of the tested cues was provided through additional subjective measures. All eye models were overall easy to read and were able to direct participants’ attention. The anthropomorphic robot eyes were most efficient at shifting participants’ attention which was revealed by faster manual and saccadic reaction times. In addition, a robot equipped with anthropomorphic eyes was perceived as being more competent. Abstract anthropomorphic robot eyes therefore seem to trigger a reflexive reallocation of attention. This points to a social and automatic processing of such artificial stimuli.
A comparison of Fourier and POD mode decomposition methods for high-speed Hall thruster video
Authors: Brooks J. W. , Kaptanoglu A. A. , McDonald M. S.
Published: July 2023

Hall thrusters are susceptible to large-amplitude plasma oscillations that impact thruster performance and lifetime and are also difficult to model. High-speed cameras are a popular tool to study these dynamics due to their spatial resolution and are a popular, nonintrusive complement toin situprobes. High-speed video of thruster oscillations can be isolated (decomposed) into coherent structures (modes) with algorithms that help us better understand the evolution and interactions of each. This work provides an introduction, comparison, and step-by-step tutorial on established Fourier and newer Proper Orthogonal Decomposition (POD) algorithms as applied to high-speed video of the unshielded H6 6-kW laboratory model Hall thruster. From this dataset, both sets of algorithms identify and characterizem= 0 andm> 0 modes in the discharge channel and cathode regions of the thruster plume, as well as mode hopping between them= 3 andm= 4 rotating spokes in the channel. The Fourier methods are ideal for characterizing linear modal structures and also provide intuitive dispersion relationships. By contrast, the POD method tailors a basis set using energy minimization techniques that better captures the nonlinear nature of these structures and with a simpler implementation. Together, the Fourier and POD methods provide a more complete toolkit for studying Hall thruster plasma instabilities and mode dynamics. Specifically, we recommend first applying POD to quickly identify the nature and location of global dynamics and then using Fourier methods to isolate dispersion plots and other wave-based physics.
Who profits from agroecology to secure food and nutrition? On access of women to markets and assets
Authors: Ume Chukwuma , Nuppenau Ernst-August , Domptail Stéphanie Eileen
Published: July 2023

In contrast to a large body of literature linking agroecology to food security through sustainable agronomic practices, research on how agroecology enhances smallholder farmers’ access to productive resources, yet necessary for food security and nutrition, is sparse in Africa. Literature does not consider the fact that agroecology practices are often adopted via entering a group that provides corresponding knowledge, network and possibly markets. We investigate the case of an agroecology group operating parallel to the dominant agri-industrial food system in Southeast Nigeria. We ask: who are the agroecology farmers? Do they improve their food status in comparison to conventional smallholders operating in the commodity oriented agro-industrial system? Who appears to benefit most among agroecology farmers? To provide answers to these questions, we collected data from 334 smallholder farmers (comprising 111 agroecology farmers and 223 non-agroecology farmers) through a stratified cluster sampling process. Descriptive statistics of our data showed that women make up 89% of the agroecology farmers in the group. We found that in both the agroecology and the conventional groups, women farmers had little access to land, even lower ownership of land, little exposure to extension services, and no access to financial credits. Thus, the sample of female farmers we addressed consists of marginal persons who operate at the margins of the capital and input-based networks and agricultural production. In contrast to the expectation of conventional hypotheses, we show that on average, agroecology farmers had lower food insecurity experiences and higher observed dietary diversity scores. Exploring more detail within the agroecology group via a quantile semi-parametric propensity score matching, we further show that women left out of conventional extension services benefit more from being in the agroecology group. Similarly, the increase in food security and nutrition was highest among those farmers who balance self-provisioning and market as food sources compared to strategies pursued mainly by one of these two sources. To these farmers, mostly women, the agroecology group provides alternative to access important resources and knowledge that they ordinarily would not have accessed being in the capitalistic food system, and which enables them to reach their nutrition goals. Our study supports a conceptualization of agroecology as an interdependency between agroecological agronomic practices, reciprocity and autonomy-fostering social innovations.
Determinants influencing fishermen’s willingness-to-participate and willingness-to-pay for conservation of small indigenous fishes: a model-based insight from Indian Sundarbans
Authors: Roy Aparna , Naskar Malay , Sinha Archana , Manna Ranjan K. , Sahu Sanjeev K. , Ekka Anjana , Das Basanta K.
Published: July 2023

Small indigenous fishes (SIF) play a crucial role in supporting the livelihoods and nutritional security of the rural population in Southern Asia. However, their abundance and diversity are under threat due to overexploitation and profitable extensive aquaculture, resulting in a sharp decline, particularly in India. Unfortunately, conservation strategies for SIF have received little attention from researchers, making it imperative to understand stakeholders’ decision-making processes to develop effective conservation strategies. This article aims to quantitatively identify the factors that influence fishermen’s intention to participate in and pay for SIF conservation efforts. The study utilizes questionnaire-based survey data from 100 households engaged in local fisheries in the rural Indian Sundarbans. To gain critical insight into fishermen’s decision processes, a bivariate logistic Generalized Additive Model is employed, focusing on willingness-to-participate and willingness-to-pay for SIF conservation. The study’s results indicate that several factors significantly influence fishermen’s willingness-to-participate in conservation efforts. These include Literacy, Conservation awareness, and Occupation. On the other hand, Conservation awareness and Household income are identified as significant determinants of fishermen’s willingness-to-pay for SIF conservation initiatives. One intriguing finding of the research is the identification of a nonlinear response-age curve for both willingness-to-participate and willingness-to-pay, as well as their interaction. Notably, the 45-50 years old age group emerged as the most likely implementers of small indigenous fish conservation strategies, suggesting that targeting this age group in conservation programs could yield positive outcomes. The study underscores the importance of various conservation strategies to bolster SIF preservation in the region. Recommendations include increasing and extending conservation awareness programs, specifically targeting suitable age-group individuals with appropriate education, household income, and occupation. These strategies are vital for formulating effective conservation guidelines that align with the specific needs and characteristics of the region. In conclusion, this research sheds light on the factors influencing fishermen’s participation and willingness to financially support the conservation of small indigenous fish in the rural Indian Sundarbans. The findings contribute valuable insights for policymakers, conservationists, and stakeholders, emphasizing the urgency of sustainable measures to safeguard SIF populations and ensure the continued livelihoods and nutritional security of the local communities.
A novel scoring system for the early detection of anastomotic leakage: bedside leak score—a pilot study
Authors: Ozata Ibrahim H. , Bozkurt Emre , Sucu Serkan , Karahan Salih N. , Camci Furkan , Cetin Feyza , Ozoran Emre , Agcaoglu Orhan , Balik Emre , Bugra Dursun
Published: July 2023

Background

Anastomotic leakage is a major complication in colorectal surgery, resulting in significant morbidity and mortality rates. Despite substantial progress in surgical technique, anastomotic leakage rates remain stable. An early diagnosis of anastomotic leaks was proven to reduce adverse outcomes and improve survival.

Objective

This study aims to find a novel scoring system for detecting anastomotic leaks using inflammatory and nutritional indicators after colorectal surgery. Our purpose was to analyze the diagnostic accuracy of leak scores ((CRPPOD3)(CRPPOD1)∗preoperativealbuminlevel) in predicting postoperative complications.

Design

The study included colorectal cancer patients who underwent curative surgery at Koc University Hospital between 2014 and 2018. Patients were categorized into two groups depending on the presence of anastomotic leaks and compared in terms of preoperative albumin levels, CRP levels in postoperative days 1 and 3, anastomotic leakage rates, length of hospital stay, and CRP quotient, which was calculated by dividing POD 3 CRP level to POD 1 CRP level. The bedside leak score is calculated by dividing the CRP quotient by the preoperative albumin level. The predictive value of bedside leak score, CRP quotient, and preoperative albumin levels in estimating anastomotic leakage was analyzed, and a cutoff value for the leak score was calculated.

Results

A total of 184 patients were included in the study. The leak score, CRP POD 3–1 ratio, and preoperative albumin levels were found to successfully detect anastomotic leakage. The area under the curve for the leak score was calculated as 0.78. The optimal cutoff value was found to be 50.3 for the bedside leak score, which shows 90.9% sensitivity and 59.3% specificity.

Conclusion

The leak score may represent a valuable diagnostic tool for detecting patients at risk for anastomotic leakage after colorectal surgery and planning a better strategy to reduce morbidity and mortality rates and associated costs. However, further multicenter studies with large cohorts are necessary to confirm these results.
Nursing strategies for the mechanically ventilated patient
Authors: Meitner Cassandra , Feuerstein Rachel A. , Steele Andrea M.
Published: July 2023

The goal of this manuscript is to provide a comprehensive and multi-disciplinary review of the best nursing practices of caring for mechanically ventilated patients. By reviewing human medicine literature, the authors will extrapolate procedures that have been found to be most effective in reducing the risk of mechanical ventilation (MV) complications. Paired with review of the current standards in veterinary medicine, the authors will compile the best practice information on mechanically ventilated patient care, which will serve as a detailed resource for the veterinary nursing staff. Written from a nursing standpoint, this manuscript aims to consolidate the nursing assessment of a mechanically ventilated patient, addressing both systemic and physical changes that may be encountered during hospitalization. The goal of this review article is to present information that encourages a proactive approach to nursing care by focusing on understanding the effects of polypharmacy, hemodynamic changes associated with MV, complications of recumbent patient care, and sources of hospital acquired infections. When applied in conjunction with the more technical aspects of MV, this manuscript will allow veterinary technicians involved in these cases to understand the dynamic challenges that mechanically ventilated patients present, provide guidance to mitigate risk, address issues quickly and effectively, and create an up-to date standard of practice that can be implemented.
Design, Control, and Assessment of a Synergy-Based Exosuit for Patients with Gait-Associated Pathologies
Authors: Jayakumar Ashwin , Bermejo-García Javier , Rodríguez Jorge Daniel , Agujetas Rafael , Romero-Sánchez Francisco , Alonso-Sánchez Francisco J.
Published: July 2023

With ever-rising population comes a corresponding rise in people with mobility issues who have difficulty handling tasks in their daily lives. Such persons could benefit significantly from an active movement assistance device. This paper presents the design of a lower-limb exosuit designed to provide the wearer with useful gait assistance. While exoskeletons have existed for a while, soft exoskeletons or exosuits are relatively new. One challenge in the design of a gait-assistance device is the reduction of device weight. In order to facilitate this, the concept of kinematic synergies is implemented to reduce the number of actuators. In this prototype, the exosuit can actuate the hip, ankle, and knee of both legs using just one single motor, and a transmission system consisting of gears and clutches. The implementation of these synergies and their advantages are detailed in this paper, as well as preliminary tests to assess performance. This was performed by testing the exosuit worn by a subject on a treadmill while taking EMG readings and measuring cable tension produced. Significant reductions by up to 35% in certain muscle activations were observed, demonstrating the validity of this prototype for gait assistance.
Physiological and Molecular Analysis Revealed the Role of Silicon in Modulating Salinity Stress in Mung Bean
Authors: Al Murad Musa , Muneer Sowbiya
Published: July 2023

Salinity stress acts as a significant deterrent in the course of optimal plant growth and productivity, and mung bean, being a relay crop in the cereal cropping system, is severely affected by salinity. Silicon (Si), on the other hand, has exhibited promising outcomes with regards to alleviating salinity stress. In order to understand the critical mechanisms underlying mung bean (Vigna radiata L.) tolerance towards salt stress, this study examined the effects of different salinity concentrations on antioxidant capacity, proteome level alterations, and influence on Si-transporter and salt-responsive genes. Salinity stress was seen to effect the gaseous exchange machinery, decrease the soluble protein and phenolic content and NR activity, and increase the accumulation of reactive oxygen species. An efficient regulation of stomatal opening upon Si application hints towards proficient stomatal conductance and CO2 fixation, resulting in efficient photosynthesis leading to proficient plant growth. The soluble protein and phenolic content showed improved levels upon Si supplementation, which indicates an optimal solute transport system from source to sink. The content of superoxide radicals showed a surge under salinity stress treatment, but efficient scavenging of superoxide radicles was noted under Si supplementation. Salinity stress exhibited more damaging effects on root NR activity, which was notably enhanced upon Si supplementation. Moreover, the beneficial role of Si was further substantiated as there was notable Si accumulation in the leaves and roots of salinity-stressed mung bean plants. Furthermore, Si stimulated competent ROS scavenging by reinforcing the antioxidant enzyme activity, as well coordinating with their isozyme activity, as expressed by the varying band intensities. Similarly, the Si-mediated increase in peroxidase activity may reveal changes in the mechanical characteristics of the cell wall, which are in turn associated with salinity stress adaptation. Proteomic investigations revealed the upregulation or downregulation of several proteins, which were thereafter identified by LC−MS/MS. About 45 proteins were identified and were functionally classified into photosynthesis (24%), metabolic process (19%), redox homeostasis (12%), transmembrane transport (10%), stress response (7%), and transcription regulation (4%). The gene expression analysis of the silicon transporter genes (Lsi1, Lsi2, and Lsi3) and SOS pathway genes (SOS1, SOS2, and SOS3) indicated the role of silicon in mitigating salinity stress. Hence, the findings of this study can facilitate a profound understanding of the potential mechanisms adopted by mung bean due to exogenous Si application during salinity stress.
Spectral Detection of Peanut Southern Blight Severity Based on Continuous Wavelet Transform and Machine Learning
Authors: Guo Wei , Sun Heguang , Qiao Hongbo , Zhang Hui , Zhou Lin , Dong Ping , Song Xiaoyu
Published: July 2023

Peanut southern blight has a severe impact on peanut production and is one of the most devastating soil-borne fungal diseases. We conducted a hyperspectral analysis of the spectral responses of plants to peanut southern blight to provide theoretical support for detecting the severity of the disease via remote sensing. In this study, we collected leaf-level spectral data during the winter of 2021 and the spring of 2022 in a greenhouse laboratory. We explored the spectral response mechanisms of diseased peanut leaves and developed a method for assessing the severity of peanut southern blight disease by comparing the continuous wavelet transform (CWT) with traditional spectral indices and incorporating machine learning techniques. The results showed that the SVM model performed best and was able to effectively detect the severity of peanut southern blight when using CWT (WF770~780, 5) as an input feature. The overall accuracy (OA) of the modeling dataset was 91.8% and the kappa coefficient was 0.88. For the validation dataset, the OA was 90.5% and the kappa coefficient was 0.87. These findings highlight the potential of this CWT-based method for accurately assessing the severity of peanut southern blight.
Evaluation of the Results of Pesticide Residue Analysis in Food Sampled between 2017 and 2021
Authors: Ambrus Árpád , Vásárhelyi Adrienn , Ripka Géza , Szemánné-Dobrik Henriett , Szenczi-Cseh Júlia
Published: July 2023

As mandated by the EU and the national risk management duties, pesticide residues were determined by four specialized laboratories in 9924 samples taken from 119 crops of economic importance in Hungary and imported foodstuffs during 2017–2021. The screening method applied covered 622 pesticide residues as defined for enforcement purposes. The limit of detection ranged between 0.002 and 0.008 mg/kg. The 1.0% violation rate concerning all commodities was lower than in the European Union. No residue was detectable in 45.9% of the samples. For detailed analyses, six commodities (apple, cherry, grape, nectarine/peach, sweet peppers, and strawberry) were selected as they were analyzed in over 195 samples and most frequently contained residues. Besides testing their conformity with national MRLs, applying 0.3 MRL action limits for pre-export control, we found that 73% of the sampled lots would be compliant with ≥90% probability based on a second independent sampling. Multiple residues (2–23) in one sample were detected in 36–50% of the tested lots. Considering the provisions of integrated pest management, and the major pests and diseases of selected crops, normally three to four and exceptionally, seven to nine active ingredients with different modes of action should suffice for their effective and economic protection within four weeks before harvest.
The Effect of Production and Post-Harvest Processing Practices on Quality Attributes in Centella asiatica (L.) Urban—A Review
Authors: Singh Rambir , Kharsyntiew Balasiewdor , Sharma Poonam , Sahoo Uttam Kumar , Sarangi Prakash Kumar , Prus Piotr , Imbrea Florin
Published: July 2023

Centella asiatica is well known for its miraculous therapeutic properties in various systems of traditional medicine across the world. However, significant variation in its pharmacological activities has been reported due to the unavailability of quality raw material and non-standardized formulations. A number of research papers have been published on the collection of C. asiatica plants from different regions for the identification of a suitable agroclimate with elite germplasms. Efforts have been made to standardize production and post-harvest practices for the availability of quality raw material with a high centelloside content. The ecological niche modeling approach revealed that the Indian subcontinent has high climatic suitability for the production of C. asiatica, and genotypes with a high content of centelloside were predominantly found in the Western Ghats, North East, Eastern Himalaya and Western Himalaya in India. Open cultivation of C. asiatica is more suitable in these agroclimatic zones in India. Cultivation under shade is also suitable in the plains of Central India. Hydroponic and tissue culture of C. asiatica has also been successfully established for the enhanced production of centelloside using supplements and elicitors such as sucrose, auxins, cytokinins, kinetin, methyl jasmonate, etc. Freeze drying has been identified as the most efficient post-harvest method for the high pharmacological activities of C. asiatica extracts.
Preductal Segmental Tubular Aortic Hypoplasia in Perinatally Died Stabyhoun Puppies
Authors: van Staveren Marie D. B. , Grinwis Guy C. M. , den Toom Marjolein L. , Szatmári Viktor
Published: July 2023

Background: A high perinatal mortality rate in the Stabyhoun breed prompted one of the Dutch breeding organizations to start an investigation. Preductal segmental tubular aortic hypoplasia is an extremely rarely documented congenital vascular anomaly in dogs, and it is suspected to be the result of constriction of ectopic ductal tissue in the aortic wall at birth. Methods: Over a period of 18 months, Stabyhoun puppies that were stillborn, died or were euthanized before 3 weeks of age were submitted to post-mortem examination at the reporting institution. Pathologic findings were documented. Results: Eight Stabyhoun puppies were submitted during the study period. In five of them, a severe preductal segmental tubular aortic hypoplasia was found. Two of the five puppies were stillborn, and three died spontaneously or were euthanized. Conclusions: Preductal tubular aortic hypoplasia was found in an unusually high frequency in the examined Stabyhoun puppies. Because the condition is believed to cause clinical signs only after birth, this anomaly cannot explain the death of the stillborn puppies. However, it might be responsible for cardiogenic pulmonary edema in the postnatal period. Routine dissection of the great vessels in perinatally deceased puppies would help to establish the prevalence of congenital anomalies of the aorta.
Assessment of Preference Behavior of Layer Hens under Different Light Colors and Temperature Environments in Long-Time Footage Using a Computer Vision System
Authors: Kodaira Vanessa , Siriani Allan Lincoln Rodrigues , Medeiros Henry Ponti , De Moura Daniella Jorge , Pereira Danilo Florentino
Published: July 2023

As for all birds, the behavior of chickens is largely determined by environmental conditions. In many production systems, light intensity is low and red feather strains have low contrast with the background, making it impossible to use conventional image segmentation techniques. On the other hand, studies of chicken behavior, even when using video camera resources, depend on human vision to extract the information of interest; and in this case, reduced samples are observed, due to the high cost of time and energy. Our work combined the use of advanced object detection techniques using YOLO v4 architecture to locate chickens in low-quality videos, and we automatically extracted information on the location of birds in more than 648 h of footage. We develop an automated system that allows the chickens to transition among three environments with different illuminations equipped with video cameras to monitor the presence of birds in each compartment, and we automatically count the number of birds in each compartment and determine their preference. Our chicken detection algorithm shows a mean average precision of 99.9%, and a manual inspection of the results showed an accuracy of 98.8%. Behavioral analysis results based on bird unrest index and permanence time indicate that chickens tend to prefer white light and disfavor green light, except in the presence of heat stress when no clear preference can be observed. This study demonstrates the potential of using computer vision techniques with low-resolution, low-cost cameras to monitor chickens in low-light conditions.
Piloting an International Comparison of Readily Accessible Online English Language Advice Surrounding Responsible Cat Ownership
Authors: Dalais Reece J. , Calver Michael C. , Farnworth Mark J.
Published: July 2023

Cats are popular companion animals globally. While the general academic definition of responsible cat ownership is agreed upon, committing to responsible cat ownership is multifaceted, often reflecting regional priorities and values. Utilising a virtual private network (VPN), an English-language online search for ‘responsible cat ownership’ was applied from major cities in 10 different nations, accounting for five different geographic regions and nine different geographic sub-regions. Data were extracted from the first 20 webpages of each search and included author affiliation, country of webpage origin, and all recommendations towards responsible cat ownership. Searches identified 58 different webpages, 142 duplicate results, and 16 different recommendations. Both before (60.5%) and after (58.6%) duplicate exclusion, irrespective of region, most webpages originated from Australia, so recommendations may lack local nuance in other countries. Similarly, local government webpages were the most common author affiliation both before (35.5%) and after (37.9%) duplicate exclusion—moreover, most Australian webpages were authored by local government (55.9%). More than half of all webpages recommended registration and microchipping (65.5%), desexing (65.5%), and containment (60.3%), probably due to the predominance of local government and Australian webpages online—reflecting Australia’s strong legislative stance. Both Australia and New Zealand showed majority recommendations for containment but not for environmental and behavioural enrichment in households. This may be partially explained by the significantly higher agreement in Australia and New Zealand that cats threaten valued wildlife in cities, towns, and rural areas. Unlike the Oceanian nations, other countries clearly recommended improved understanding and provision for cat needs, but with little evidence of support for containment. Thus, divergent welfare considerations inform major webpages associated with attitudes towards cat ownership internationally. Encouraging containment, a responsible cat ownership practice with benefits for cats and wildlife, may be more likely to succeed outside Oceania if cat welfare is emphasised instead of wildlife protection. Within Oceania, more attention could be given to enhancing the well-being of contained cats.
Equine Psittacosis and the Emergence of Chlamydia psittaci as an Equine Abortigenic Pathogen in Southeastern Australia: A Retrospective Data Analysis
Authors: El-Hage Charles , Legione Alistair , Devlin Joanne , Hughes Kristopher , Jenkins Cheryl , Gilkerson James
Published: July 2023

Chlamydia psittaci is an important zoonotic pathogen. Although primarily a pathogen of birds, from which infection can spillover into humans and other mammalian hosts, the importance of C. psittaci as a cause of equine reproductive loss and the risk of infection to humans in contact with infected horses are increasingly being recognised in Australia and elsewhere. Despite the risks to both human and equine health, C. psittaci infection in horses is incompletely understood. This study aimed to update and summarise cases of equine psittacosis in Australia in the period 2018–2022, thus addressing a knowledge gap relating to recent cases in this country. These cases were identified from the examination of records held by state and federal veterinary authorities and from a review of published cases. A total of 31 cases were identified. Spatial and temporal trends were identified, with cases being more prevalent in winter and spring and geographically restricted to Victoria and New South Wales. The results show that cases of equine reproductive loss due to C. psittaci are consistent and ongoing and demonstrate the importance of routinely considering C. psittaci in diagnostic investigations. The need for ongoing study to better understand this important zoonotic pathogen is evident.
Plastic Entanglement Poses a Potential Hazard to European Hedgehogs Erinaceus europaeus in Great Britain
Authors: Thrift Emily , Nouvellet Pierre , Mathews Fiona
Published: July 2023

A questionnaire to gather evidence on the plastic entanglement of the European hedgehog (Erinaceus europaeus) was sent to 160 wildlife rehabilitation centres in Great Britain. Fifty-four responses were received, and 184 individual admissions owing to plastic entanglement were reported. Death was the outcome for 46% (n = 86) of these cases. A high proportion of Britain’s hedgehogs enter rehabilitation centres annually (approximately 5% of the national population and potentially 10% of the urban population), providing a robust basis for assessing the minimum impacts at a national level. We estimate that 4000–7000 hedgehog deaths per year are attributable to plastic, with the true rate likely being higher, since many entangled hedgehogs—in contrast to those involved in road traffic accidents—will not be found. Population modelling indicates that this excess mortality is sufficient to cause population declines. Although the scale of the impact is much lower than that attributable to traffic, it is nevertheless an additional pressure on a species that is already in decline and presents a significant welfare issue to a large number of individuals.