bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of US Involvement & Withdrawal from Afghanistan on Afghan Refugees in Pakistan
Authors: Ayesha Amir  , Dr. Syed Khawaja Alqama
Published: February 2025

This article analyses the socio-economic and security issues presented by Afghan refugees in Pakistan, especially in the aftermath of U.S. engagement and eventual withdrawal from Afghanistan. The research examines the historical context of Afghan migration to Pakistan, emphasising the effects of the Afghan Jihad and the War on Terror, which resulted in the arrival of millions of refugees. The article examines the pressure on Pakistan's resources, infrastructure, and security, emphasising the increase in militancy and social unrest in regions accommodating refugees. The research used an exploratory design to assess the broader implications of this issue for Pakistan and Afghanistan. The results indicate that return, conducted under secure and voluntary circumstances, is the most feasible approach to mitigate Pakistan's burden while facilitating the return of refugees to a stable Afghanistan. The article advocates for collaboration among the Afghan government, Pakistan, and the international community to establish favourable conditions for the restoration process, emphasising infrastructure, security, and economic prospects. The resolution of the refugee problem is deemed essential for promoting peace, stability, and development in the region.
Topical Gel of Mesenchymal Stem Cell-Conditioned Medium-induced Serum Injury Accelerates Wound Healing in Skin Excision Tissue
Authors: Berlian Mukti Arja , Alif Iffan , Subchan Prasetyowati , Handoyo Frigi Eko , Husain Sofian Azalia , Husni Ahmad Sidiq  , Arlinda Dyken Dwi , Adityani Resanti
Published: February 2025

Introduction: Umbilical cord-derived mesenchymal stem cells (UC-MSCs) accelerating wound closure by increasing VEGF and PDGF level leading to re-epithelialization, cell infiltration, and angiogenesis. It has been found that MSC-conditioned medium (MSC-CM) can enhance migration of fibroblasts in scratch assays. However, the effect of MSC-CM-induced serum injury (MSC-CM-S) formulated in gel to accelerate wound healing remains unclear. This study aims to evaluate the effect of several doses of topical gel of MSC-CM-S in accelerating wound healing. Methods: The MSCs were cultured medium-supplemented serum injury of wounded rat (8:1) to get MSC-CM-S. The topical gel of MSC-CM-S was made by base gel supplemented with MSC-CM-S.  Eighteen Wistar rats were randomly assigned into control (C) and treatment groups (T1, T2). Groups were received serum-free medium gel (C), 25 µl MSC-CM-S in topical gel (T1), 50 µl MSC-CM-S in topical gel (T2), twice daily for 9 days. PDGF and VEGF level and fibroblast density were measured by ELISA and HE staining at day 3 and 6, respectively. Results: This study showed that there was significant increase of VEGF and PDGF level along with a significant increase of fibroblast density at day 3 and 6. The T2 showed optimum enhancement level of VEGF, PDGF and fibroblast density. Conclusion: Topical gel of MSC-CM-S was effective to accelerate wound closure by enhancing PDGF and VEGF level in full-thickness skin defect rats.
The Effect of Hypoxia on the Soluble Molecules of Human Umbilical Cord-Derived Mesenchymal Stem Cells (UC-MSCs)
Authors: Widyatmoko Agus , Alif Iffan , Irawan Risky Candra Satria , Handoyo Frigi Eko , Sidiq Husni Ahmad
Published: February 2025

Background: Umbilical cord-derived stem cells (UC-MSCs) are essential cell sources for cell-based therapies in regenerative medicine. Hypoxia is a key element of the stem cell niche and crucial for the preservation of UC-MSCs properties. The normal growth conditions for UC-MSCs are under atmospheric oxygen concentrations of 20–21%. However, the administration of UC-MSCs in inflammatory conditions provides oxygen-deficient environments. Thus, treating UC-MSCs with low oxygen exposure provides them with more survival and recovery potential.
Objective:  In this study, we assessed the impact of hypoxia incubation for 12 h on the UC-MSCs proteome.
Methods: UC-MSCs were isolated from UC patients regarding informed consent. At passage 5, in 80% confluent, UC-MSCs were incubated in 5% O2 for 12 h. The morphology of UC-MSCs was assessed using a microscope. The level of FGF-2, FGF-8, TNF-α, and HSP-70 were analyzed using ELISA.
Results: Hypoxic condition could change their morphology and enhance the cellular density compared to normoxic conditions in vitro. The level of FGF-2, FGF-8, TNF-α, and HSP-70 were significantly increased after the hypoxic condition of UC-MSCs compared to normoxia.
Conclusion: Our findings suggest that the hypoxic condition was able to induce survival capacity and soluble molecules secreted by UC-MSCs.
The Effect of X-Ray Radiation to IL-10 Levels in Secretome Mesenchymal Stem Cells Cosmeceutical Product
Authors: Antari Arini Dewi , Ghaissani Shabrina Syifa , Prawitasari Salindri , Haryono Erlina , Adityani Resanti
Published: February 2025

Background: X-ray radiation has been widely used in the pharmaceutical industry because it regenerates and repairs damaged tissues. Objective: In this study, we evaluate the effect of X-ray radiation on the secretome cosmeutical product. Methods: We conducted interleukin 10 (IL-10) analysis by ELISA in each product sample after exposure to X-ray radiation. Results: The levels of IL-10 in each sample were significantly lower than those in the control samples. Moreover, the level of IL-10 in the product samples was significantly higher than that of the control sample. Conclusion: In conclusion, exposure to radiation during shipping or storage of skin care products can potentially damage the proteins in the products by inducing the production of reactive oxygen species (ROS) and decreasing the treatment effectiveness.
Therapeutic Potential of Secretome-Derived Wharton's Jelly Mesenchymal Stem Cells in Psoriasis Vulgaris: A Case Study
Authors: Azzahara Salma Yasmine , Agustina Rita , Prawitasari Salindri
Published: February 2025

Background: Psoriasis is a chronic, immune-mediated skin disease that also has systemic manifestations. Case: In this report, we discuss our findings about a 47-years old psoriasis suffering male patient with a Psoriasis Area Severity Index (PASI) score of 10.8, treated with Wharton’s Jelly Mesenchymal Stem Cells-derived Secretome (S-MSCs). Remarkably, complete regression was recorded within a treatment period of a week only. Result: The patient demonstrated a decrease in PASI, from 10.8 to 3.2 after 1 infusion and followed by 4 intramuscular injections of S-MSCs. Bioactive factors secreted by MSCs, cytokines and growth factors, are very likely to be the principal molecules which play a vital role in inflammatory modulation and skin tissue regeneration. No serious adverse events were noted for the patient as a result of secretome infusion and intramuscular injection. Conclusion: This report demonstrates safety and promises to be an effective strategy using S-MSCs treatment for managing the psoriatic issue and, thus, may offer as an alternative approach to overcome the limitations of the cell-based therapy.
Non-Contact Electro Capacitive Cancer Therapy (ECCT) Modulate the mRNA Expression of PDGF and IL-1 in DMBA-induced Breast Cancer Rat
Authors: Hidayah Nurul
Published: February 2025

Background: Breast cancer remains the most prevalent cancer among women globally, with significant mortality rates. Traditional therapies, such as surgery, chemotherapy, and radiotherapy, are associated with severe side effects and resistance, highlighting the need for alternative treatments. Electro-Capacitive Cancer Therapy (ECCT) is a promising non-invasive approach that uses low-intensity electric fields to selectively target cancer cells. Objective: This study aims to investigate the molecular mechanisms of ECCT, particularly its effects on key molecules such as PDGF and IL-1 in a DMBA-induced rat breast cancer model. Materials and Methods: The study used a post-test-only control group design with four groups: NINT (normal tissue), NIT (untreated tumor tissue), INT (DMBA-induced tumor tissue), and IT (ECCT-treated tumor tissue). ECCT was applied at 150 kHz for 21 days. mRNA expressions of PDGF and IL-1 were quantified using quantitative RT-PCR. Results: ECCT significantly reduced the mRNA expression of PDGF and IL-1 in treated tumor tissues (IT) compared to untreated tumor tissues (INT), bringing their levels closer to those observed in normal tissue (NINT). This suggests that ECCT downregulates key pro-angiogenic and pro-inflammatory molecules involved in tumor progression. Conclusion: In conclusion, the non-contact ECCT with a frequency of 150 kHz might downregulate PDGF and IL-1 mRNA expression in rat breast tumor tissue.
Gestión de la deserción educativa de los estudiantes con discapacidad desde la Universidad Nacional de Educación
Authors: Castillo Pinos Karina Maribel
Published: February 2025

La educación inclusiva universitaria en Ecuador ha tenido mucha relevancia para estudiarla y determinar si existe el aprovechamiento necesario de parte de las personas con discapacidad, sin embargo, aún se precisan de aspectos a mejorar para garantizar la permanencia de los estudiantes. El objetivo fue analizar cómo se gestiona la deserción educativa de los estudiantes con discapacidad desde la UNAE. La metodología se basó en un diseño no experimental-transversal, bajo un tipo descriptivo y explicativo de investigación, métodos lógicos y empíricos; la unidad de análisis estuvo compuesta de 39 estudiantes con discapacidad que cursan alguna carrera de la UNAE, así como se consideró a 7 directores de carrera de esta institución; los instrumentos aplicados fueron el cuestionario y le guion de preguntas. Los resultados reflejaron que los factores más influyentes para que un estudiante deje la universidad son las limitaciones económicas, percepción de que no existen las condiciones adecuadas tanto físicas, tecnológicas o metodológicas, sin embargo, existe mucho compromiso docente en la UNAE, y a pesar de que algunos alumnos con discapacidad han pensado en abandonar sus estudios, consideran que la institución está comprometida con su permanencia. Se concluye que la UNAE es un referente a nivel de las universidades del Ecuador, que más promueve la inclusión educativa, sin embargo, la deserción de los alumnos se debe a diversos factores como falta de adaptaciones de infraestructura, tecnología; dificultad movilización; discriminación de parte de los compañeros; factores económicos; ausencia de metodologías inclusivas.
Impacto de la implementación de herramienta digitales en el aprendizaje de los estudiantes: contexto de Educación Básica.
Authors: Sánchez Changoluisa María Fernanda , Hallo Caiza Eduardo Paúl , Toapanta Toapanta María Elsa
Published: February 2025

El uso de herramientas digitales en la Educación Básica ha cobrado relevancia como estrategia para mejorar el aprendizaje y la participación estudiantil. Este estudio tuvo como objetivo analizar su impacto en el rendimiento académico y la percepción docente sobre su efectividad. Se utilizó un enfoque mixto, con un diseño descriptivo y correlacional, aplicando encuestas a 15 docentes para evaluar la frecuencia de uso, herramientas más utilizadas y beneficios percibidos. Los resultados indican que Educaplay es la plataforma más empleada (40%), y que el 86% de los docentes integra herramientas digitales en su enseñanza. Además, el 66.7% considera que estas mejoran el aprendizaje, lo que se respalda con la correlación de Pearson (ρ=0,721; p=0,002), que evidencia una relación positiva entre el uso de estas herramientas y el rendimiento académico en Matemática, Lengua y Literatura, y Ciencias Naturales. Se concluye que la enseñanza se ve favorecida con la implementación de los recursos que proveen las herramientas digitales al promover un aprendizaje interactivo y significativo, aunque su efectividad depende de la capacitación docente y la infraestructura tecnológica disponible. Se recomienda fortalecer el acceso equitativo a la tecnología y desarrollar programas de formación docente para optimizar su aplicación en el aula.
Prácticas evaluativas del docente en el marco de la educación global: Una revisión sistemática de las barreras para la implementación de la evaluación formativa.
Authors: Avila Orjuela Daniel Antonio , Rodriguez Leuro Angela Isabel
Published: February 2025

La evaluación del aprendizaje es un elemento fundamental en la educación que busca mejorar la adquisición de conocimientos efectivos. La presente investigación realiza una revisión sistemática de literatura sobre las prácticas evaluativas de los docentes, enfocándose en la educación primaria y secundaria en diversos países de Europa, Asia, África y Oceanía durante el periodo de 2019 a 2024.  Se utilizó el protocolo Prisma, consultando las bases de datos Sage, Science Direct, Scopus, Springer y Taylor and Francis. Se eligieron 15 artículos de investigación que examinan las prácticas evaluativas docentes en diversos países. Los resultados evidencian la transición de las prácticas evaluativas, que abarcan desde la evaluación sumativa hasta la evaluación formativa, fomentando la participación estudiantil. No obstante, persisten prácticas culturales arraigadas en la evaluación convencional, que no permiten el desarrollo de una evaluación de tipo formativa. Además de lo anterior, es importante tener en cuenta la diversidad y los estudiantes migrantes. Los estudios indican la necesidad de capacitación docente en evaluación como una estrategia para optimizar sus prácticas evaluativas y el aprendizaje de los alumnos.
Competencias clínicas del personal de Enfermería que labora en la Unidad de Cuidados Intensivos: estrategias de abordaje en situación de crisis
Authors: Cerón Parra Miryan Ximena , Cejas Martínez Magda Francisca
Published: February 2025

Esta investigación exploró las competencias clínicas en un grupo de profesionales en enfermería que laboran en atención en Unidades de Cuidados Intensivos (UCI) y su capacidad para gestionar situaciones de crisis Los resultados revelan que el personal posee un alto nivel de competencias técnicas y de comunicación, siendo la toma de decisiones críticas y el trabajo en equipo las habilidades más valoradas. Sin embargo, se identificó la necesidad de fortalecer la capacitación en gestión del estrés y adaptabilidad a cambios repentinos. La investigación subraya la importancia de la formación continua y la implementación de protocolos estandarizados para mejorar la respuesta ante crisis. Los hallazgos coinciden con estudios previos que enfatizan el papel fundamental de las competencias clínicas en la calidad de la atención en UCI, especialmente en contextos de alta complejidad.
Find the Maximum Common Substructure, and Groups Off It, For a Set of Molecules Using RDKit
Authors: Monat Jeremy
Published: February 2025

In drug discovery, the lead optimization step often involves creating analogues of a hit (a promising compound which produces a desired result in an assay) to optimize selectivity and minimize toxicity. Because it is typically easier to chemically modify the periphery of the molecule (for example the functional groups) than the scaffold, it is helpful to compare the groups off of the common scaffold.
Are the Starting Materials for Synthesizing Your Target Molecules Commercially Available?
Authors: Monat Jeremy
Published: February 2025

This utility reports whether the starting materials are commercially available for a set of synthesis targets given reactions. You give it your synthesis targets and the reaction to create each, it determines the starting materials, checks whether they are commercially available, and tells you whether each target is accessible–whether all its starting materials are commercially available.
Visualizing Nonbinary Trees: Classification of Chemical Isomers
Authors: Monat Jeremy
Published: February 2025

This example lets you visualize the hierarchy of nonbinary trees. An example is the classification of chemical isomers, which are compounds that have the same chemical formula, but different arrangements of atoms in space.
The Effect of the Wall Heat Capacity on the Unsteady Temperature Distribution Inside Buildings: a Simple Analytical Approach
Authors: Lipnicki Zygmunt , Kuczyński Tadeusz , Partyka Jacek Piotr , Weigand Bernhard
Published: February 2025

The best way to keep the required format of the manuscript is to overwrite these instructions with its text. Papers Heating buildings is important in everyday life. Especially today, every saving of thermal energy is important
to stop the global warming of our planet. In this context, the influence of the thermal capacity of walls on the time-dependent temperature change inside buildings is most often ignored in the literature. Therefore, this work aims to investigate the influence of the thermal capacity of the wall on the time-dependent change of the internal temperature in a building room by developing a simple theoretical model enabling the calculation of unsteady heat transfer through the building wall, taking into account the role of the thermal capacity of the external wall. The theoretical analysis also takes into account the heat capacity of the air occurring in a limited cubic space, which has not been taken into account in other studies on this topic. Two cases of time-dependent changes in outdoor temperature are considered here: a constant outdoor temperature and a periodically changing ambient temperature. After applying a few simplifying assumptions, the problem can be reduced to a system of ordinary differential equations, which can then be solved analytically. Thus, the developed methodology can be used to design partitions in energy-efficient buildings.
Statystical Analysis in Integration of Thermal Imaging and GNSS Satellite Measurements in Relation to Geological Structure as a Method to Improve the Accuracy of Displacement Determination of Engineering Structures
Authors: Zygmunt Mark
Published: February 2025

Numerous publications have confirmed the important contribution of applying GNSS satellite measurements in geologically unstable areas to the displacement measurements of engineering objects. Along with linking GNSS measurements of benchmarks considered to be stable in the long term to the nearest reference stations at appropriate measurement intervals. So, it was possible to improve the accuracy of measurements of vertical and horizontal coordinates in the area of Szczecin, ushering in coordinate errors of less than 2 and 5 mm. For objects of strategic use such as natural gas tanks located in salt formations, however, these values are too high. The displacement of salt formations is 0.5 mm per year. Therefore, I decided to review existing measurement methods in two areas with different geological structures - Szczecin and Wroclaw NW and SW Poland - as numerous spectrums of SAR methods. As a different method, I present the advantages of the radiometric method with the prospect of performing surveys in the abovementioned areas. The publication focuses on statistical analyses, and GNSS and radiometric field measurements are in progress.
Tobacco Factories in Lublin: Past, Present, Future
Authors: Janus Krzysztof
Published: February 2025

Despite the highly detrimental effects of tobacco on human health, the trade in tobacco products has historically been, and is likely to remain, a highly profitable venture. This article presents the complex history of the former Tobacco Factories in Lublin, which were part of the Polish Tobacco Monopoly. During the interwar period, this sector generated up to 16% of the state’s revenue. The development of the facility was primarily driven by immense market demand, which fueled the rapid expansion of the Lublin factory. This expansion necessitated the acquisition of adjacent land and the construction of large buildings, reaching a peak area of approximately 100,000 square meters. The progression of the enterprise was not halted by the actions of War, rather production ceased due to a lack of raw materials for processing, not due to damage or looting of equipment. Development was ultimately arrested only after systemic changes occurred, rendering production unprofitable and leading the underfunded facility to declare bankruptcy. This paper also discusses the transformations that have taken place in recent years following the conclusion of the facility’s liquidation process. A new company acquired the property and gradually began investing in and attempting to revitalize this degraded area of the city, which possesses significant potential despite its limited opportunities. The article addresses the historical context of the site, its current state, and possible directions for the future development of this somewhat forgotten and greatly undervalued location on the map of Lublin.
Energy management in cooling system using hybrid optimization clustering technique
Authors:   Dept. of Electrical, Telecommunication & Computer/Biomedical Engineering, Kampala International University Uganda, Elnazeer Ai Hamid Abdalla , Mohammed Ishag Ahmed ,   Dept. of Electrical, Telecommunication & Computer/Biomedical Engineering, Kampala International University Uganda, Department of Electrical and Electronic Engineering, University of Nyala, Nyala, Sudan, Mohammed Elnour A/Alla ,   School of Electronics Engineering, Sudan University of Science and Technology (SUST), Khartoum, Sudan, Tamador Elkhansaa .J Mohamed ,   Dept. of Electrical, Telecommunication & Computer/Biomedical Engineering, Kampala International University Uganda, Saadelnour Abdueljabbar Adam ,   Dept. of Electrical, Telecommunication & Computer/Biomedical Engineering, Kampala International University Uganda, School of Electronics Engineering, Sudan University of Science and Technology (SUST), Khartoum, Sudan, Bubu Pius Erheyovwe ,   Dept. of Electrical, Telecommunication & Computer/Biomedical Engineering, Kampala International University Uganda, Akankunda Joan ,   Dept. of Electrical, Telecommunication & Computer/Biomedical Engineering, Kampala International University Uganda
Published: February 2025

Malaysia is situated in Southeast Asia, close to the equator, and as a result of its position, it has hot and humid weather. Because of the impact of the high ambient temperature, more than 50% of the building's energy is used to meet the cooling load demand. Reducing energy consumption in cooling systems without compromising cooling load demand is still an issue to manage. Numerous research studies have been conducted on cooling load demand and its power usage in order to regulate energy consumption and cooling load. These studies have included fuzzy c-mean (FCM) and fuzzy subtractive clustering (FSC) have been involved in cooling systems. As a result, when it comes to deciding how many clusters to use and deploying big data, both FCM and FSC are constrained. This work proposes accelerated particle swarm optimization (APSO) and FSC techniques to achieve this. By adjusting the cluster radius of the FSC-based APSO algorithm. To tune and adjust the cluster radius, a proportional-integral (PI) controller is adopted. The main objective of the APSO is to fine-tune the data clustering parameters. The outcome of the proposed FSC-APSO based PI technique is to identify the input-output dataset for evaluating electricity usage and cooling load demand. The energy usage and load demand in this work are evaluated based on the influence of ambient temperature and relative humidity. The results show that the FSC-APSO technique reduces energy consumption by 10% without compromising comfort-cooling demand. The result is validated using actual data obtained from Latexx Manufacturing Sdn Bhd, Malaysia.
Challenges and opportunities in optimizing hybrid renewable energy systems for grid stability and socio-economic development in rural Sub-saharan Africa: A narrative review
Authors:   Department of Electrical, Telecom. & Computer Engineering, Kampala International University, Uganda, Val Hyginus Udoka Eze , Eniru Emmanuel Innocent ,   Department of Electrical, Telecom. & Computer Engineering, Kampala International University, Uganda, Adacha Itafe Victor ,   Department of Electrical, Telecom. & Computer Engineering, Kampala International University, Uganda, Kelechi John Ukagwu ,   Department of Electrical, Telecom. & Computer Engineering, Kampala International University, Uganda, Ugwu Chinyere Nneoma ,   Department of Electrical, Telecom. & Computer Engineering, Kampala International University, Uganda, Ogenyi Fabian C ,   Department of Electrical, Telecom. & Computer Engineering, Kampala International University, Uganda, Ibeabuchi Mbonu Charles ,   Department of Electrical, Telecom. & Computer Engineering, Kampala International University, Uganda
Published: February 2025

The global shift towards renewable energy systems is critical for combating climate change, enhancing energy security, and achieving sustainability. Hybrid renewable energy systems, which integrate multiple renewable sources such as solar, wind, and hydropower, promise increased reliability and efficiency in energy generation. However, their integration into national grids presents significant technical, economic, and regulatory challenges. This narrative review systematically analyzes the hurdles and opportunities associated with hybrid renewable energy systems, drawing from diverse case studies and technological advancements. It discusses technical challenges, including grid stability and interconnection compatibility, and economic issues related to high initial investments and financing. Furthermore, the review highlights regulatory barriers and the necessity for supportive frameworks. It concludes with insights into the potential of hybrid systems to foster technological innovation and contribute to sustainable development and climate change mitigation.
Tomato Price Fluctuations and Vendor Profitability in Hoima Central Market, Hoima Oil City, Uganda
Authors: Alinaitwe Godfrey , Kusiima Annet
Published: February 2025

Purpose: This study aimed to examine the impact of tomato price fluctuations on the profitability of vendors in Hoima Central Market, Hoima Oil City, Uganda. It sought to identify the primary drivers of price volatility and their effects on market dynamics, providing actionable insights for stakeholders in the tomato value chain.
Methodology: The research employed a combination of descriptive statistics and regression analysis to explore the relationship between price fluctuations and vendor profitability. Data were collected through surveys and interviews with tomato vendors, capturing details on income, trading practices, and the challenges associated with price changes.
Findings: The study found that weather variations, pest and disease outbreaks, and seasonal supply shifts were the leading causes of price fluctuations. Other factors, such as natural disasters and supply chain inefficiencies, further exacerbated price instability. Vendors adopted strategies like adjusting purchase quantities in response to price changes and entering long-term agreements with suppliers to stabilize prices. Despite these challenges, most vendors experienced positive profitability, with an average profit of UGX 145,373.48. Regression analysis confirmed a statistically significant relationship between price fluctuations and profitability, highlighting the critical role of effective price management.
Originality/Value: This study provides a detailed analysis of how price volatility impacts vendor profitability in a developing market context. Its findings emphasize the need for interventions such as targeted vendor training programs, the formation of cooperatives, and enhanced financial literacy to improve market resilience and vendor livelihoods. The insights contribute to a better understanding of market dynamics in the tomato value chain and inform strategies to mitigate the effects of price fluctuations.
ADVANCING RESERVOIR CHARACTERIZATION: A COMPARATIVE ANALYSIS OF XG BOOST AND ANN FOR ACCURATE POROSITY PREDICTION
Authors: Abe James , Adekanye Damilola
Published: February 2025

This research presents a comprehensive analysis of porosity prediction in reservoir characterization using two powerful machine learning algorithms, XGBoost and Artificial Neural Networks (ANN). Well log data, including GR log, resistivity log, density log, sonic log, neutron log, and por_insitu, were employed for training and validation, with the latter serving as core data for porosity at identical depths. The initial XGBoost prediction yielded an accuracy of 57.54%, prompting the implementation of performance metrics and hyperparameter tuning. Through these optimizations, the XGBoost model's accuracy skyrocketed to an impressive 96.75%, with refined performance metrics, including MAE of 0.766158, MSE of 1.047763, and RMSLE of 0.038324. Leveraging the well log data and core data validation, the XGBoost model demonstrated outstanding accuracy levels, holding immense promise for reservoir characterization and hydrocarbon exploration. On the other hand, the ANN model underwent data standardization and architecture experimentation, ultimately finding the model with ten hidden layers to be the best performer. This model achieved a mean absolute error (MAE) of 1.87 for the train data and 4.08 for the test data. Comparing the two models, the XGBoost model clearly outperformed the ANN model in accuracy for porosity prediction, making it the preferred choice for reservoir applications. The project's success highlights the efficacy of XGBoost in handling complex geological data and its ability to deliver accurate predictions for porosity. Additionally, the ANN model's performance demonstrates the importance of optimizing network architecture and activation functions to achieve accurate results. The findings of this study underscore the significance of machine learning in reservoir characterization, offering valuable insights into decision-making processes in the petroleum industry.
Cloud Computing Unveiled: A Beginners Guide to the Cloud Revolution
Authors: Gawali Dr. Rajesh R.
Published: February 2025

This book “Cloud Computing Unveiled: A Beginner’s Guide to the Cloud Revolution” is a comprehensive guide that provides a thorough understanding of cloud computing concepts, architecture, and platforms. The book is divided into five units, covering topics such as introduction to cloud computing, cloud service models, virtualization, cloud architecture, and fundamentals of cloud platforms. With a focus on practical applications and real-world examples, this book is ideal for beginners, students, and professionals looking to gain a solid understanding of cloud computing. The book covers popular cloud platforms such as Amazon Web Services (AWS), Google Cloud Platform (GCP), Microsoft Azure, and IBM Cloud, making it a valuable resource for anyone looking to explore the world of cloud computing.
Bioactive compounds and Antimicrobial Investigation of Assyrian Plum (Cordia myxa L.)
Authors: Hussain Khaskheli Aftab , Korejo Farzana , Ali Shaikh Asghar , Habib Ahmed Naqvi Syed , Sami Dahri Abdul , Lashari Safia , Patrick Asim
Published: February 2025

Assyrian plum or Lasura (Cordia myxa L.) is a widely recognized as diverse traditional medicinal plant. Different parts of this species have been utilized for the treatment of various diseases. However, information about the bioactive compounds and antimicrobial properties of Assyrian plum is scarce. This study was designed to analyze bioactive compounds, such as total antioxidants, phenolics, flavonoids, alkaloids, tannins, terpenoids, and saponins in 20% ethanol, methanol, acetone and aqueous extracts from different segments of Assyrian plum. The investigation revealed substantial amounts of these bioactive compounds in the studied segments, indicating the plant's potential therapeutic value. In addition, the highest amount of total protein content was found in ethanol extracts of root, fruit, leaves and stem (34.7 ± 1.08 mg/ml, 34.2 ± 1.16 mg/ml, 34.1 ± 1.12 mg/ml, 30.0 ± 0.02 mg/ml) respectively. Methanol extract of fruit exhibited the maximum quantity of total sugar (54.0 ± 0.32 mg/mL), while methanol extract of fruit displayed significantly higher levels of reducing sugar (0.159 ± 0.0004 mg/ml) compared to other parts of Assyrian plum extracts. The extracts of different parts of Assyrian plum strongly inhibited the growth of human pathogenic bacteria Escherichia coli and Staphylococcus aureus. Furthermore, 20% extracts of different segments of Assyrian plum also successfully ceased the growth of Aspergillus fumigatus and Aspergillus niger. This study provides valuable information about the bioactive composition of Assyrian plum and highlights its potential as a source of natural antimicrobial agents, supporting its traditional medicinal applications.
Acute abdomen in the era of immune checkpoints inhibitors – what the surgeon needs to know: A narrative review
Authors: Symeonidou Elissavet , Taitzoglou Ioannis , Papaioannou Maria , Papamitsou Theodora , Karachrysafi Sofia , Rallis Grigorios , Fylaktou Asimina , Vagdatli Eleni , Chatzigriva Eftixia , Savvas Ioannis , Zacharioudakis Georgios , Kamparoudis Apostolos , Ballas Konstantinos
Published: February 2025

Immune checkpoint inhibitors (ICI) have been approved for the treatment of a variety of malignancies. Immune-related adverse events are rare and might affect a lot of different organs including the intestines. Enterocolitis is a common complication characterised by symptoms such as diarrhoea, abdominal pain, and vomiting. In rare circumstances, bowel perforation, obstruction, or even toxic megacolon might appear. The proper therapeutic management of these conditions is based on case reports or case series. Conservative management is the standard of care in the case of ileus, however, the safety of performing a bowel anastomosis has not been answered yet. This study aims to raise awareness among the medical community, and specifically surgeons, regarding the intestinal complications of ICI, as the uprising administration of these targeted therapies makes this knowledge necessary.
Pengaruh Digital Markting Terhadap Peningkatan Penjualan di Apotek Wonomulyo
Authors: Jumrah Marufi  , Nursahdi Saleh  , Sri Wahyuni Zainuddin
Published: February 2025

Penelitian ini bertujuan untuk memberikan bukti empiris mengenai pengaruh digital marketing dalam meningkatkan penjualan dengan menguji masing-masing variabel yang terlibat. Objek penelitian adalah Apotek Wonomulyo, yang berlokasi di Wonomulyo, dengan pengumpulan dan penyajian data yang relevan sebagai dasar analisis. Metode penelitian yang digunakan melibatkan 40 pelanggan sebagai responden. Teknik analisis data menggunakan regresi linier sederhana dengan bantuan perangkat lunak SPSS versi 20 untuk Windows. Hasil penelitian menunjukkan bahwa digital marketing memiliki pengaruh signifikan terhadap peningkatan penjualan di Apotek Wonomulyo. Hal ini mengindikasikan pentingnya strategi pemasaran digital dalam mendukung keberhasilan bisnis, khususnya di sektor farmasi.
Pengaruh Literasi Digital Terhadap Kecenderungan Perilaku Cyberbullying Remaja di Media Sosial.
Authors: Kiki Amelya Arifin  , Rahmi Tria  , Nur Inda
Published: February 2025

Tujuan penelitian ini adalah untuk mengetahui Pengaruh Literasi Digital Terhadap Kecenderungan Perilaku Cyberbullying Remaja Dimedia Sosial Di Kec. Wonomulyo. Tehknik pengumpulan data menggunakan kuosioner
Hasil penelitian ini membuktikan bahwa kasus cyberbullying biasa terjadi pada kalangan remaja di kec. Wonomulyo. Hal ini dapat dilihat dari beberapa hasil penelitian yang telah di simpulkan bahwa remaja lebih sering mendapatkas kasus lewat akun media sosial yang mereka gunakan di media sosial, untuk itu kita harus lebih berhati-hati dalam menggunakan sosial media dan lebih memperketat privasi akun yang kita gunakan untuk berkontibusi di media sosial.
Pengaruh Electronic Commerce (E-Commerce) Terhadap Peningkatan Pendapatan UMKM Di Kecamatan Wonomulyo Kabupaten Polewali Mandar
Authors: Ummi Kalsum  , Andi Gunawan Ratu Chakti  , Rahmi Tria
Published: February 2025

E-Commerce di Indonesia berkembang pesat, memberikan dampak positif bagi pelaku usaha, konsumen, dan masyarakat, meskipun penyebarannya belum merata di seluruh wilayah. Bagi pelaku UMKM, E-Commerce   menjadi strategi penting untuk memperluas jangkauan pasar, meningkatkan efisiensi operasional, serta meminimalkan biaya promosi. E-Commerce   juga berperan dalam meningkatkan kesadaran terhadap produk lokal dan mendorong inovasi dalam menghadapi persaingan pasar. Di Kecamatan Wonomulyo, banyak pelaku UMKM yang memanfaatkan E-Commerce   untuk meningkatkan pendapatan dengan menjangkau konsumen secara lokal maupun global. Faktor-faktor seperti sumber daya manusia, infrastruktur internet, dan ketenagalistrikan memengaruhi efektivitas pemanfaatan E-Commerce. Penelitian ini bertujuan untuk menganalisis pengaruh Electronic Commerce (E-Commerce) terhadap peningkatan pendapatan UMKM di Kecamatan Wonomulyo, Kabupaten Polewali Mandar, serta memberikan gambaran strategis mengenai peran E-Commerce dalam mendukung pertumbuhan ekonomi lokal di era digital. Hasil penelitian ini membuktikan bahwa E-Commerce   berpengaruh signifikan positif terhadap peningkatan pendapatan UMKM di Kecamatan Wonomulyo. Hal dilihat dari omzet penjualan, jumlah pelanggan, dan jumlah pendapatan sebagai sarana untuk melakukan pemasaran produk dan kegiatan transaksi jual beli setelah memanfaatkan E-Commerce   untuk kegiatan usaha bagi pelaku UMKM.
Determinan E-Quality Service Dan E-Trust Terhadap Costumer Satisfaction (Studi : Pengguna Aplikasi MyTelkomsel Di Kabupaten Mamuju)
Authors: Ansar  , Suharlina
Published: February 2025

Penelitian ini bertujuan untuk menganalisis pengaruh e-quality service dan e-trust terhadap customer satisfaction pengguna aplikasi MyTelkomsel di Kota Mamuju. Penelitian ini merupakan penelitian eksplantori dengan pendekatan kuantitatif. populasi penelitian sebanyak 27.882 pengguna MyTelkomsel yang ada di Mamuju, penentuan sampel memakai persamaan slovin, dengan teknik sampling purposive, kriteria yang digunakan adalah pengguna Aplikasi MyTelkomsel dengan range periode 2 tahun keatas. Pengujian kualitas instrumen penelitian menggunakan uji validitas dan uji reliabilitas. Alat analisis data menggunakan regresi linear berganda, selanjutnya pengujian hipotesis menggunakan uji parsial dan uji simultan. Hasil penelitian mengungkapkan bahwa e-quality service memiliki pengaruh positif dan signifikan terhadap customer satisfaction, dengan nilai t hitung sebesar 7,403 dan signifikansi 0,000. Demikian pula, e-trust juga menunjukkan pengaruh positif dan signifikan terhadap customer satisfaction, dengan t hitung 4,713 dan signifikansi 0,000. Analisis simultan mengungkapkan bahwa e-quality service dan e-trust secara bersama-sama memiliki pengaruh signifikan terhadap customer satisfaction, terbukti dengan nilai F hitung 113,047 dan signifikansi 0,000. Temuan ini mengindikasikan bahwa peningkatan kualitas layanan elektronik dan kepercayaan pelanggan dapat meningkatkan kepuasan pengguna. Oleh karena itu, disarankan untuk meningkatkan user experience melalui desain antarmuka yang intuitif, kecepatan aplikasi, dan fitur yang relevan, serta menjaga keamanan dan privasi data pengguna untuk membangun kepercayaan dan loyalitas pelanggan agar tercipta kepuasan pengguna.
Menumbuhkan Digitalpreneur dan Literasi Digital Mahasiswa melalui Praktik Shopee Affiliate
Authors: Sahabudin Arfah
Published: February 2025

Penelitian ini bertujuan untuk menganalisis bagaimana praktik Shopee Affiliate dapat menumbuhkan jiwa digitalpreneur dan meningkatkan literasi digital mahasiswa. Melalui pendekatan kualitatif, data dikumpulkan melalui wawancara mendalam dan observasi partisipatif terhadap 15 mahasiswa  program studi Bisnis Digital. Penelitian ini menggali pengalaman mereka untuk memahami dampaknya terhadap keterampilan pemasaran digital dan kewirausahaan. Hasil penelitian menunjukkan bahwa mahasiswa mengalami peningkatan signifikan dalam kemampuan memanfaatkan platform digital untuk bisnis, terutama dalam memahami e-commerce, pemasaran online, dan penggunaan media sosial sebagai alat promosi. Selain itu, mahasiswa juga memperoleh wawasan praktis tentang cara kerja program afiliasi, termasuk strategi memilih produk yang sesuai dengan target audiens. Namun, tantangan seperti kurangnya pengalaman awal dalam pemasaran digital, keterbatasan akses ke sumber daya pembelajaran, dan kesulitan menentukan produk yang tepat untuk dipromosikan masih menjadi hambatan yang perlu diatasi. Penelitian ini merekomendasikan perlunya bimbingan intensif, akses ke materi pembelajaran yang relevan, dan integrasi program afiliasi dalam kurikulum pendidikan tinggi untuk memaksimalkan manfaatnya. Dengan demikian, mahasiswa dapat memperoleh keterampilan praktis yang relevan dengan dunia digital dan bisnis, sekaligus mendorong mereka menjadi digitalpreneur yang kompeten. Temuan ini memberikan kontribusi penting bagi pengembangan kurikulum pendidikan tinggi yang lebih responsif terhadap kebutuhan industri digital.
Caracterización de posibles delitos sexuales en el municipio de Armenia según los informes técnicos médicos legales sexológicos del Instituto Nacional de Medicina Legal y Ciencias Forenses, Seccional Quindío, durante los años 2005 a 2009
Authors: Collazos Catalina , Ríos Hernán Andrés , Torres Jairo David
Published: February 2025

La violencia sexual es una problemática creciente y a la vez oculta, por todas las implicaciones que genera alrededor del afectado. Sus consecuencias son devastadoras en los ámbitos físico, sicológico y social. El abordaje de este fenómeno requiere un conocimiento detallado de su comportamiento, ausente en la población del municipio de Armenia. Se realizó un estudio descriptivo, retrospectivo, de los informes sexológicos forenses sobre Posibles Delitos Sexuales (PDS) registrados en la base de datos del Instituto Nacional de Medicina Legal y Ciencias Forenses (INMLCF), Seccional Quindío, durante los años 2005 a 2009, analizando variables cualitativas como edad, sexo y relación con el agresor, entre otras.Entre los resultados relevantes se encontró que el 87% de las víctimas corresponden a menores de edad, en el 75% de los casos la víctima presentaba un parentesco familiar con el agresor o por lo menos era un conocido y el 74,78% de los casos ocurrieron en la vivienda de la víctima. Finalmente, este trabajo encamina a las autoridades competentes a hacer uso de esta información para conocer la población que puede ser presa del delito sexual y así reducir, y ojalá eliminar, esta problemática.
Relación entre el overkill por arma blanca y el femicidio íntimo
Authors: Vergel John , Díaz Diana , Martínez Óscar
Published: February 2025

A continuación se presentará un caso de femicidio íntimo cuyos hallazgos muestran un patrón de lesión overkill con arma blanca, en cuello y tórax. Dado que esta necropsia se realizó dentro de una actividad docente de pregrado en Medicina, quisimos realizar una revisión bibliográfica que intentara responder cómo se relacionan el overkill con arma cortopunzante y el femicidio íntimo, la cual permite profundizar nuestra comprensión de este fenómeno y reflexionar sobre potenciales oportunidades para una nueva línea de investigación sobre esta temática.
Evaluación de medidas antropométricas mandibulares en cadáveres de adultos jóvenes masculinos colombianos, mestizos, con patrón ancestral de predominio caucasoide, como ayuda quirúrgica para la reconstrucción mandibular
Authors: Gnecco Juan Pablo , Ayala Serrano Germán Alberto , Crespo Sequera Efraín , Gil Aguirre María Carolina , Gómez Rentería Alí , Torres Gutiérrez Iván , Zabaleta José Luis
Published: February 2025

Los objetivos de este estudio fueron describir, clasificar y categorizar el tamaño mandibular con base en medidas antropométricas tomadas en material de autopsia del Instituto Nacional de Medicina Legal y Ciencias Forenses de Bogotá (Colombia), determinando su correlación con la edad, talla e índice de masa corporal, para establecer parámetros extrapolables, útiles en cirugía reconstructiva mandibular. Se trabajó con 192 cadáveres adultos que permitieron su identificación con la cuartera básica (sexo, filiación ancestral, edad biológica y estatura) y sin variación de la anatomía normal por factores tafonómicos.
Durante el estudio se analizaron diferentes variables, clasificadas en tres grupos, uno de medidas lineales, otro de medidas angulares y el último de otras medidas. El análisis estadístico descriptivo mostró que la edad promedio tuvo un valor de 23,9 años con una desviación estándar de 3,6. La variable talla incluyó 130 hipsisomos (67,7%), 50 mesosomos (26,0%) y 12 camesomos (6,2%). El índice de masa corporal se distribuyó en 114 cadáveres de peso normal (59,3%), 61 con sobrepeso (31,7%), 17 obesos (8.8%) y ninguno desnutrido.
Se establecieron tres categorías: la clase I o de 'mandíbulas promedio', correspondiente al 45,3% del total global de especímenes y no caracterizada por ninguna modalidad de talla. La clase II o de 'mandíbulas grandes', que corresponde al 15,1% del total, asociada con individuos de talla alta; y finalmente, la clase III o de 'mandíbulas pequeñas' correspondiente al 39,5% asociada con individuos de talla media. Se concluyó que la edad, el peso y el IMC son factores que no modifican las dimensiones mandibulares, pero la talla sí; existen algunas características antropométricas mandibulares específicas de la población colombiana que pueden ser tenidas en cuenta en reconstrucción mandibular.
Estimación de la estatura a partir de longitud de metacarpianos en una muestra de población mestiza colombiana: estudio piloto
Authors: Villalobos Fuentes Carlos Andrés , Sanabria Medina César
Published: February 2025

Los laboratorios de antropología forense en Colombia reciben a diario una gran cantidad de casos complejos, cuyos restos óseos suelen encontrarse incompletos o con altos grados de erosión. En este tipo de casos el antropólogo debe recurrir a metodologías de análisis poco comunes o alternativas, que se acomoden a las estructuras óseas disponibles. La presente investigación adelantó un estudio piloto para determinar si la estimación de la estatura a partir de metacarpianos es una herramienta útil y confiable para el análisis forense de casos complejos.
Se midieron los cinco metacarpianos derechos e izquierdos en una muestra de 94 individuos (63 masculinos y 31 femeninos) plenamente identificados, con promedio de edad al morir de 45 años, cuya estatura en la cédula o en necropsia es conocida. La longitud interarticular fue tomada a las cinco estructuras óseas. Se determinaron los índices de correlación de Pearson y se compararon para determinar la estructura ósea más apropiada para estimar la estatura.
Se calcularon fórmulas de regresión simple para la estimación de la estatura a partir de cada uno de los cinco metacarpianos. Los índices de correlación y errores estándar de la estimación de cada una de las fórmulas obtenidas son satisfactorios y muy similares a los reportados en estudios internacionales. A pesar de que la estimación de la estatura a partir de metacarpianos representa una herramienta confiable de análisis forense, es necesario aumentar el tamaño de la muestra de referencia y evaluar estas fórmulas con una muestra de control, para poder aplicarlas en contextos forenses reales.
PENGARUH PEMBERDAYAAN DAN PENGAWASAN KARYAWAN TERHADAP KINERJA KARYAWAN (STUDI PADA PERUSAHAAN DAERAH AIR MINUM KOTA MAKASSAR)
Authors: Ali Firman , Ardi Ardiansyah Ali
Published: February 2025

Pendekatan yang terintegrasi antara pemberdayaan dan pengawasan karyawan dapat menjadi kunci dalam menciptakan kinerja yang optimal dan berkelanjutan dalam sebuah perusahaan. Penelitian ini bertujuan untuk menganalisis pengaruh pemberdayaan dan pengawasan terhadap kinerja karyawan pada Perusahaan Daerah Air Minum di Kota Makassar. Metode kuantitaif dengan pendekatan survey digunakan dalam penelitian ini melalui pengisian kuesioner yang disebarkan kepada karyawan pada perieode Maret – Mei Tahun 2024. Sebanyak 355 karyawan tetap yang diambil sebagai populasi dengan hanya mengambil sampel 78 responden. Teknik analisis data  menggunakan analisis linear berganda, Uji t, Uji F dan uji Koefesien determinasi (R²). Hasil penelitian menunjukkan bahwa secara parsial baik variabel pemberdayaan maupun pengawasan masing-masing berpengaruh positif dan signifikan terhadap kinerja karyawan, serta pemberdayaan dan pengawasan karyawan secara simultan berpengaruh positif dan signifikan terhadap kinerja karyawan.