bluuebunny/crossref_metadata_2025 huggingface dataset:
Cerebrospinal fluid levels of proenkephalin and prodynorphin are differentially altered in Huntington’s and Parkinson’s disease
Authors: Barschke Peggy , Abu-Rumeileh Samir , Al Shweiki M. H. D. Rami , Barba Lorenzo , Paolini Paoletti Federico , Oeckl Patrick , Steinacker Petra , Halbgebauer Steffen , Gaetani Lorenzo , Lewerenz Jan , Ludolph Albert Christian , Landwehrmeyer Georg Bernhard , Parnetti Lucilla , Otto Markus
Published: June 2022

Background

Proenkephalin (PENK) and prodynorphin (PDYN) are peptides mainly produced by the striatal medium spiny projection neurons (MSNs) under dopaminergic signaling. Therefore, they may represent candidate biomarkers in Huntington’s disease (HD) and Parkinson’s disease (PD), two neurodegenerative diseases characterized by striatal atrophy and/or dysfunction.

Methods

Using an in-house established liquid chromatography−tandem mass spectrometry (LC–MS/MS) method in multiple reaction monitoring mode (MRM) we measured cerebrospinal fluid (CSF) levels of PENK- and PDYN- derived peptides in patients with HD (n = 47), PD (n = 61), Alzheimer’s disease (n = 11), amyotrophic lateral sclerosis (n = 14) and in 92 control subjects. Moreover, we investigated the possible associations between biomarkers and disease severity scales in HD and PD and the effect of dopaminergic therapy on biomarker levels in PD.

Results

In HD, CSF PENK- and PDYN-derived peptide levels were significantly decreased compared to all other groups and were associated with disease severity scores. In PD, both biomarkers were within the normal range, but higher PDYN levels were found in dopamine-treated compared to untreated patients. In PD, both CSF PENK and PDYN did not correlate with clinical severity scales.

Conclusions

CSF PENK- and PDYN-derived peptides appeared to be promising pathogenetic and disease severity markers in HD, reflecting the ongoing striatal neurodegeneration along with the loss of MSNs. In PD patients, CSF PDYN showed a limitative role as a possible pharmacodynamic marker during dopaminergic therapy, but further investigations are needed.
Evaluation of classifications of the monopodial bronchopulmonary vasculature using clustering methods
Authors: Labode Jonas , Dullin Christian , Wagner Willi L. , Myti Despoina , Morty Rory E. , Mühlfeld Christian
Published: June 2022

Mammalian pulmonary arteries divide multiple times before reaching the vast capillary network of the alveoli. Morphological analyses of the arterial branches can be challenging because more proximal branches are likely biologically distinct from more peripheral parts. Thus, it is useful to group the arterial branches into groups of coherent biology. While the generational approach of dichotomous branching is straightforward, the grouping of arterial branches in the asymmetrically branching monopodial lung is less clear. Several established classification methods return highly dissimilar groupings when employed on the same organ. Here, we established a workflow allowing the quantification of grouping results for the monopodial lung and tested various methods to group the branches of the arterial tree into coherent groups. A mouse lung was imaged by synchrotron x-ray microcomputed tomography, and the arteries were digitally segmented. The arterial tree was divided into its individual segments, morphological properties were assessed from corresponding light microscopic scans, and different grouping methods were employed, such as (fractal) generation or (Strahler) order. The results were ranked by the morphological similarity within and dissimilarity between the resulting groups. Additionally, a method from the mathematical field of cluster analysis was employed for creating a reference classification. In conclusion, there were significant differences in method performance. The Strahler order was significantly superior to the generation system commonly used to classify human lung structure. Furthermore, a clustering approach indicated more precise ways to classify the monopodial lung vasculature exist.
Prevalence of lung tumors in patients with esophageal squamous cell carcinoma and vice versa: a systematic review and meta-analysis
Authors: van Tilburg Laurelle , van de Ven Steffi E. M. , Spaander Manon C. W. , van Kleef Laurens A. , Cornelissen Robin , Bruno Marco J. , Koch Arjun D.
Published: June 2022

Purpose

Recent reports suggest an increased prevalence of lung second primary tumors (LSPTs) in esophageal squamous cell carcinoma (ESCC) patients and vice versa. However, the exact prevalence of SPTs remains unclear and screening for these SPTs is currently not routinely performed in western countries. We aimed to report on the prevalence of LSPTs in patients with ESCC and esophageal second primary tumors (ESPTs) in patients with lung cancer (LC).

Methods

Databases were searched until 25 March 2021 for studies reporting the prevalence of LSPTs in ESCC or vice versa. Pooled prevalences with 95% confidence intervals (CI) of SPTs were calculated with inverse variance, random-effects models and Clopper–Pearson.

Results

Nineteen studies in ESCC patients and 20 studies in LC patients were included. The pooled prevalence of LSPTs in patients with ESCC was 1.8% (95% CI 1.4–2.3%). For ESPTs in LC patients, the pooled prevalence was 0.2% (95% CI 0.1–0.4%). The prevalence of LSPTs in ESCC patients was significantly higher in patients treated curatively compared to studies also including palliative patients (median 2.5% versus 1.3%). This difference was consistent for the ESPT prevalence in LC patients (treated curatively median 1.3% versus 0.1% for all treatments). Over 50% of the detected SPTs were squamous cell carcinomas and were diagnosed metachronously.

Conclusion

Patients with ESCC and LC have an increased risk of developing SPTs in the lungs and esophagus. However, the relatively low SPT prevalence rates do not justify screening in these patients. Further research should focus on risk stratification to identify subgroups of patients at highest risk of SPT development.
Affecting behavioural change through empowerment: conceptual insights from theory and agricultural case studies in South Asia
Authors: Hamilton Serena H. , Merritt Wendy S. , Carter Lucy , Chakraborty Arnab , Cosijn Michaela , Lim-Camacho Lilly , Mishra Rajeshwar , Syme Geoff , Das Mahanambrota , Ray Dhananjay
Published: June 2022

Affecting behavioural change is a common underlying goal across environmental and agricultural sciences, from climate change mitigation and adaptation, biodiversity conservation, water management, to crop diversification. However, many projects fail to drive or sustain change despite sound science and good intentions. This paper draws on existing theories of behavioural change to construct a conceptual framework that explores pathways to initiate and sustain change through the lens of empowerment, self-efficacy and agency. The framework is demonstrated with case studies from a project in India and Bangladesh that examined social inclusion of marginalised and poor farmers in the context of intensifying agriculture. The framework and case studies highlight that a number of conditions are needed to affect meaningful change including that target beneficiaries are suitably motivated, believe in their own capability and power to enact change and have access to the necessary resources. We propose the framework as a tool to help project teams explore the underlying elements of the process of change when designing, implementing and assessing agricultural or environmental projects and interventions. We contend that behavioural and social change needs to be explicitly fostered in such endeavours to achieve better and longer-term outcomes for the people and environment.
Unusual pattern of skipped or shortened moulting of flight feathers in late-breeding Common Shelducks
Authors: Cimiotti Dagmar S. , Hötker Hermann , Garthe Stefan
Published: June 2022

Experimental studies have shown that individual wildfowl can shorten or skip moulting if the time between breeding and wintering is short; however, studies in wild birds are scarce. We tracked nine Common Shelducks Tadorna tadorna during the breeding and moulting seasons and determined the flightless time during moulting based on typical movement patterns. We found different movement patterns for two late-breeding females, suggesting that they skipped or shortened the moult of their flight feathers. These results provide a link between previous experimental studies and the situation in wild birds, likely reflecting an individual trade-off between the times allocated to moulting and breeding, respectively.
Fatigue behaviour of laser powder bed fusion (L-PBF) Ti–6Al–4V, Al–Si–Mg and stainless steels: a brief overview
Authors: Afroz L. , Das R. , Qian M. , Easton M. , Brandt M.
Published: June 2022

Fatigue and crack growth characteristics are essential cyclic properties of additively manufactured (AM) components for load-bearing applications, which are less reported in the literature than static properties. The fatigue behaviour of AM components is more complicated than those produced by conventional fabrication techniques (casting and forging) because of the multiplicity of different influencing factors like defect distribution, inhomogeneity of the microstructure and consequent anisotropy. Therefore, it is crucial to understand fatigue performance under different loading conditions to enhance AM application in aerospace, automotive, and other industries. The present work summarises the published literature for fatigue properties of popular metals (Ti–6Al–4V, Al–Si–Mg and stainless steels) produced by the laser powder-bed-fusion (L-PBF) process. Moreover, process parameters, post-processing treatments and microstructures of these alloys are discussed to evaluate the current state-of-the-art of fatigue and crack growth properties of L-PBF metals. The static properties of these alloys are also included to incorporate only those cases for which fatigue behaviour are discussed later in this review to make a correlation between the static and fatigue properties for these alloys. The effects of build orientation, microstructure, heat treatment, surface roughness and defects on fatigue strength and fatigue crack growth threshold are observed and critically analysed based on available literature. This study also highlights the common and contrary findings in the literature associated with various influential factors to comprehensively understand the cyclic loading behaviour of L-PBF produced metal alloys.
Impact of Sample Geometry and Surface Finish on VM12-SHC Ferritic–Martensitic Steel Under Cyclic Steam Atmosphere Operating Conditions
Authors: Feijoo M. Mosquera , Oder G. , Neumann R. Saliwan , Buchheim M. , Kranzmann A. , Olbricht J.
Published: June 2022

The steam side oxidation of ferritic–martensitic VM12-SHC steel was investigated under thermo-cyclic conditions in water steam at 620/320 °C and 30 bar with a focus on assessing the influence of pre-oxidation time, specimen geometry and surface finish. The specimens were pre-oxidized under isothermal conditions in water steam at 620 °C and 30 bar for 500 h or 1500 h. After pre-oxidation treatment, all specimens were subjected up to 258 thermal cycles. Three different geometries—rectangular coupons, U-shaped ring segments and ring samples—were investigated to evaluate the influence of open/closed shape, and flat/curved surface on corrosion rate. At the same time, two types of surface finish were considered: “as received” and “ground.” The formation of a protective scale by pre-oxidation was investigated. EBSD and ESMA analyses revealed that the Cr-content of the alloy appeared to be insufficient for obtaining a protective oxide scale under studied conditions, at the same time the anayses confirmed that initial oxidation depends on presence of minor alloying elements as Si and Mn, strong oxide formers which can alter the kinetics and morphology of the corrosion reaction. Moreover, rectangular coupons with small wall thickness and flat surface exhibited the highest corrosion rate, while “ground” curved samples showed only local oxidation. This indicates that for same pre-oxidation time, oxidation kinetics is controlled by curvature.
The interplay between nitrogenated allelochemicals, mineral nutrition and metabolic profile in barley roots
Authors: Maver Mauro , Trevisan Fabio , Miras-Moreno Begoña , Lucini Luigi , Trevisan Marco , Cesco Stefano , Mimmo Tanja
Published: June 2022

Aims

The alkaloid hordenine is one of the major allelochemicals involved in the allelopathic ability of barley (Hordeum vulgare L.), whose biosynthesis and accumulation is preferentially located in roots. Hordenine appears to have been unintentionally favored during domestication in modern and cultivated barley cultivars at the expense of another alkaloid, gramine. In this study, we assessed the content of hordenine and its two precursors, N-methyltyramine (NMT) and tyramine, in roots and root exudates of the modern spring barley cv. Solist, and particularly how they are affected due to nutrient deficiencies.

Methods

We monitored the three metabolites during the early phases of barley growth i.e., up to 8 days, applying HPLC time-course and both target and untargeted metabolomic approaches. Barley plants were grown either in full nutrient solutions or in specific nutrient shortage conditions (N, S, P and Fe).

Results

Results confirmed a strong decrease of the allelochemical accumulation (hordenine and the two precursors) in roots and in root exudates during both 24 h and 8 days time-course experiments. Yet, the overall tyramine content was approximately tenfold lower compared to the other two compounds. In addition, plants subjected to nitrogen (-N), sulfur (-S), phosphorus (-P) and iron (-Fe) deprivation showed nutrient-dependent accumulation of hordenine, N-methyltyramine and tyramine, as well as of other secondary metabolites. Indeed, the synthesis of hordenine and N-methyltyramine was trigged under nutrient deficiencies.

Conclusions

In conclusion, this study highlighted the impact of nutrient availability on the growth-dependent accumulation patterns of all the three compounds investigated in modern barley roots.
Is Vitamin D Supplementation an Effective Treatment for Hypertension?
Authors: Chen Songcang , Gemelga Gio , Yeghiazarians Yerem
Published: June 2022

Purpose of the Review

Results from epidemiological studies suggest that vitamin D (VD) deficiency (VDD) may be a cause of hypertension (HTN). However, the results of randomized clinical trials (RCTs) designed to address the impact of VD supplementation on reducing blood pressure (BP) remain equivocal. To determine whether VD might serve as a beneficial treatment option for a specific subset of hypertensive patients, we performed a stratified analysis of RCT data and addressed problems associated with some methodological issues.

Recent Findings

HTN is caused by multiple factors. VDD may be one of the factors contributing to the development of this disorder. There are more than 70 RCTs that examined the impact of VD supplementation on BP. These RCTs can be classified into four groups based on their respective study populations, including participants who are (1) VD-sufficient and normotensive, (2) VD-deficient and normotensive, (3) VD-sufficient and hypertensive, and (4) VD-deficient and hypertensive.

Our evaluation of these studies demonstrates that VD supplementation is ineffective when used to reduce BP in VD-sufficient normotensive subjects. VD supplementation for five years or more may reduce the risk of developing HTN specifically among those with VDD. Interestingly, findings from 12 RCTs indicate that daily or weekly supplementation, as opposed to large bolus dosing, results in the reduction of BP in VD-deficient hypertensive patients. Our ongoing research focused on elucidating the mechanisms of VDD-induced HTN will ultimately provide evidence to support the development of etiology-specific prevention and treatment strategies focused on HTN in the VD-deficient population.
Effects of Kindness- and Compassion-Based Meditation on Wellbeing, Prosociality, and Cognitive Functioning in Children and Adolescents: a Systematic Review
Authors: Perkins Nicole , Sehmbi Taranjit , Smith Patrick
Published: June 2022

Objectives

Interventions involving kindness- and compassion-based meditation (KCBM) have been shown to have various benefits for adults, and there is growing interest in using KCBMs with children. This systematic review explores the effects of KCBM on wellbeing, prosociality, and cognitive functioning in children and adolescents.

Methods

Studies were eligible if they examined interventions that contained a proportion of KCBM above a set threshold, included child participants only, used any or no control group, and included at least one outcome measure related to wellbeing, prosociality, or cognitive functioning. Studies were assessed for quality using the Quality Assessment Tool for Quantitative Studies, and findings were synthesised narratively.

Results

A systematic literature search of 11 databases up to February 2020 identified 3,073 papers. Ten studies were eligible for inclusion in the review, including 807 children. There was evidence of improvements in wellbeing in 47% of wellbeing outcome measures (including stress, anxiety, depression, negative affect, markers of inflammation, mindfulness, and self-compassion). Prosociality and cognitive functioning (visual perception and motor accuracy) were examined in 1 study each, and there was evidence of improvements in both outcomes. Effect sizes ranged from small to large. There was some evidence that interventions were more effective with younger, non-clinical populations and where intervention teachers were experienced. Study quality was generally weak.

Conclusions

There was no strong evidence base for positive effects of KCBM with children. However, the findings of the review are encouraging given the early stage of development of the field, and further research is warranted. Recommendations for future research include more robust methodological design, improved reporting, and a focus on developmental mechanisms of change.

Systematic Review Registration

PROSPERO CRD42014013065.
Trees as brokers in social networks: Cascades of rights and benefits from a Cultural Keystone Species
Authors: Djoudi Houria , Locatelli Bruno , Pehou Catherine , Colloff Matthew J. , Elias Marlène , Gautier Denis , Gorddard Russell , Vinceti Barbara , Zida Mathurin
Published: June 2022

Indigenous trees play key roles in West African landscapes, such as the néré tree (Parkia biglobosa(Jacq.) R.Br. ex G.Don). We applied social–ecological network analysis to understand the social–ecological interactions around néré. We documented the benefits néré provides and the multiple social interactions it creates amongst a large range of actors. The flows of rights over the trees and benefits from them formed two hierarchical networks, or cascades, with different actors at the top. The two forms of power revealed by the two cascades of rights and benefits suggest possible powers and counter-powers across gender, ethnicity, and age. We documented how the tree catalyses social interactions across diverse groups to sustain vital social connections, and co-constitute places, culture, and relationships. We argue that a paradigm shift is urgently needed to leverage the remarkable untapped potential of indigenous trees and Cultural Keystone Species in current global restoration and climate change agendas.
Sorption-enhanced gasification of municipal solid waste for hydrogen production: a comparative techno-economic analysis using limestone, dolomite and doped limestone
Authors: Santos Mónica P. S. , Hanak Dawid P.
Published: June 2022

Sorption-enhanced gasification has been shown as a viable low-carbon alternative to conventional gasification, as it enables simultaneous gasification with in-situ CO2 capture to enhance the production of H2. CaO-based sorbents have been a preferred choice due to their low cost and wide availability. This work assessed the technical and economic viability of sorption-enhanced gasification using natural limestone, doped limestone with seawater and dolomite. The techno-economic performance of the sorption-enhanced gasification using different sorbents was compared with that of conventional gasification. Regarding the thermodynamic performance, dolomite presented the worst performance (46.0% of H2 production efficiency), whereas doped limestone presented the highest H2 production efficiency (50.0%). The use of dolomite also resulted in the highest levelised cost of hydrogen (5.4 €/kg against 5.0 €/kg when limestone is used as sorbent), which translates into a CO2 avoided cost ranging between 114.9 €/tCO2 (natural limestone) and 130.4 €/tCO2 (dolomite). Although doped limestone has shown a CO2 avoided cost of 117.7 €/tCO2, this can be reduced if the production cost of doped limestone is lower than 42.6 €/t. The production costs of new sorbents for CO2 capture and H2 production need to be similar to that of natural limestone to become an attractive alternative to natural limestone.
Optimal scheduling in cloud healthcare system using Q-learning algorithm
Authors: Li Yafei , Wang Hongfeng , Wang Na , Zhang Tianhong
Published: June 2022

Cloud healthcare system (CHS) can provide the telemedicine services, which is helpful to cope with the difficulty of patients getting medical service in the traditional medical systems. However, resource scheduling in CHS has to face with a great of challenges since managing the trade-off of efficiency and quality becomes complicated due to the uncertainty of patient choice behavior. Motivated by this, a resource scheduling problem with multi-stations queueing network in CHS is studied in this paper. A Markov decision model with uncertainty is developed to optimize the match process of patients and scarce resources with the objective of minimizing the total medical costs that consist of three conflicting sub-costs, i.e., medical costs, waiting time costs and the penalty costs caused by unmuting choice behavior of patients. For solving the proposed model, a three-stage dynamic scheduling method is designed, in which an improved Q-learning algorithm is employed to achieve the optimal schedule. Numerical experimental results show that this Q-learning-based scheduling algorithm outperforms two traditional scheduling algorithms significantly, as well as the balance of the three conflicting sub-costs is kept and the service efficiency is improved.
Dual graph characteristics of water distribution networks—how optimal are design solutions?
Authors: Sitzenfrei Robert , Hajibabaei Mohsen , Hesarkazzazi Sina , Diao Kegong
Published: June 2022

Urban water infrastructures are an essential part of urban areas. For their construction and maintenance, major investments are required to ensure an efficient and reliable function. Vital parts of the urban water infrastructures are water distribution networks (WDNs), which transport water from the production (sources) to the spatially distributed consumers (sinks). To minimize the costs and at the same time maximize the resilience of such a system, multi-objective optimization procedures (e.g., meta-heuristic searches) are performed. Assessing the hydraulic behavior of WDNs in such an optimization procedure is no trivial task and is computationally demanding. Further, deciding how close to optimal design solutions the current solutions are, is difficult to assess and often results in an unnecessary extent of experiment. To tackle these challenges, an answer to the questions is sought: when is an optimization stage achieved from which no further improvements can be expected, and how can that be assessed? It was found that graph characteristics based on complex network theory (number of dual graph elements) converge towards a certain threshold with increasing number of generations. Furthermore, a novel method based on network topology and the demand distribution in WDNs, specifically based on changes in ‘demand edge betweenness centrality’, for identifying that threshold is developed and successfully tested. With the proposed novel approach, it is feasible, prior to the optimization, to determine characteristics that optimal design solutions should fulfill, and thereafter, test them during the optimization process. Therewith, numerous simulation runs of meta-heuristic search engines can be avoided.
Real-Time Detection and Recognition of Railway Traffic Signals Using Deep Learning
Authors: Staino Andrea , Suwalka Akshat , Mitra Pabitra , Basu Biswajit
Published: June 2022

Automated detection and recognition of traffic signals are of great significance in railway systems. Autonomous driving solutions are well established for urban rail transportation systems. Many metro lines in service worldwide have reached the highest grade of automation where the train is automatically operated without any staff on board. However, autonomous driving is still an open challenge for mainline trains, due to the complexity of the mainline environment. In this context, automated recognition of wayside signals can help to minimise the risk of human error owing to low visibility and fatigue. It represents a key step towards the fully autonomous train. In this article we present a deep learning based approach for the above task. The You Only Look Once (YOLOv5) is used for detection and recognition of wayside signals. A heuristic is used to recognise blinking states. We consider FRSign dataset, a large collection of over 100,000 images of traffic signals from some of the trains in French Railways. A distilled and cleaned version of the dataset curated by us is used for training. The trained network has low computational overhead and can recognise traffic signals in real time and under diverse field conditions. It has robust performance even for complex scenes having multiple signals and light sources, and in adverse circumstances such as rain and night environments. The refined version of the dataset is published as open for validation and further research and development.
A Systematic Literature Review of Specialist Policing of Rape and Serious Sexual Offences
Authors: Dalton Charlotte T. , Barrett Sophie , Horvath Miranda A. H. , Davies Kari
Published: June 2022

The policing of rape and serious sexual offences (RASSO) is increasingly under scrutiny, with rising reporting rates, high attrition rates, and ever-decreasing charge and conviction rates. Internationally there appear to be common inadequacies in RASSO investigations. Given these issues, policing specialism may be an effective tool to improve the investigation of RASSO. This article systematically draws together the existing literature from around the world on the use of a specialist approach to tackling RASSO. A systematic literature review was conducted, and 18 papers were included for analysis based on the inclusion/exclusion criteria. From these documents, five key themes were found: investigation procedures and processes; victim care; specialist training, knowledge and skills; officer wellbeing and capacity; and policing outcomes. The review highlighted that the specialist policing of RASSO can improve the investigative process on several levels: improving the efficacy of the individual components of the investigation; better engagement with victims; better officer wellbeing; and overall improved policing outcomes. Further research is required into the specific mechanisms that results in improvements into the investigative process, the set-up of such specialist units, as well as how training in this area can be as effective as possible.
Experimental and numerical analyses of nitrogen oxides formation in a high ammonia-low hydrogen blend using a tangential swirl burner
Authors: Alnasif A. , Mashruk S. , Kovaleva M. , Wang P. , Valera-Medina A.
Published: June 2022

Ammonia has been considered as a novel fuel for decarbonization purposes. However, emissions from combustion systems are still posing a problem. Therefore, experimental and numerical simulations have been conducted to study the concentration of exhaust emissions (Nitric oxide “NO”, Nitrous oxide “N2O”) from burning the ammonia/hydrogen (NH3/H2) blend 85/15 (vol%). The effects were measured at various thermal powers ranging 10 to 20 kW and with different Reynolds numbers from 20,000—40,000. The experimental points were numerically investigated in the Ansys CHEMKIN-Pro environment employing seven chemical kinetic mechanisms taken from the literature. All experiments have been undertaken at standard atmospheric conditions. The experimental results showed that both NO and N2O gradually increased when the Reynolds number increased from 20,000 to 40,000. Along with that, the concentration of NO emissions at the exhaust reported minimum level when the Re = 20,000 due to lower reactivity radical formation, all that led to a deterioration of the flame characteristics. Also, the integrated radical intensities of NO*, OH*, NH*, and NH2* demonstrate an increasing trend as Re increased from 20,000 to 40,000. In terms of thermal power, N2O suffered an abrupt decrease when the thermal power increased up to 15 kW, while the opposite occurs for NO. In addition, the radicals intensity of OH*, NH*and NH2* figures show an increase in their concentration when the thermal power increased up to 15 kW then decreased with increasing thermal intensity to reach 20 kW, reflecting into increased NO productions and decreased N2O levels. The numerical analysis showed that Stagni, Bertolino, and Bowen Mei were the most accurate mechanisms as these give a good prediction for NO and N2O. The study also showed that the chemical reaction (HNO + O2 ↔ NO + HO2) is the main source of NO formation. While the chemical reaction (NH + NO ↔ N2O + H) is responsible for the formation of N2O by consuming NO and when there will be abundance in NH radicals. Finally, dealing with a blended fuel of high ammonia concentration encourages ammonia chemistry to become more dominant in the flame. It decreases the flame temperature, hence lowering heat loss between the flame and the surrounding.
Functional Analysis
Authors: van Neerven Jan
Published: June 2022

This comprehensive introduction to functional analysis covers both the abstract theory and applications to spectral theory, the theory of partial differential equations, and quantum mechanics. It starts with the basic results of the subject and progresses towards a treatment of several advanced topics not commonly found in functional analysis textbooks, including Fredholm theory, form methods, boundary value problems, semigroup theory, trace formulas, and a mathematical treatment of states and observables in quantum mechanics. The book is accessible to graduate students with basic knowledge of topology, real and complex analysis, and measure theory. With carefully written out proofs, more than 300 problems, and appendices covering the prerequisites, this self-contained volume can be used as a text for various courses at the graduate level and as a reference text for researchers in the field.
Sharing Power, Securing Peace?
Authors: Cederman Lars-Erik , Hug Simon , Wucherpfennig Julian
Published: June 2022

Does power sharing bring peace? Policymakers around the world seem to think so. Yet, while there are many successful examples of power sharing in multi-ethnic states, such as Switzerland, South Africa and Indonesia, other instances show that such arrangements offer no guarantee against violent conflict, including Rwanda, Yugoslavia, Zimbabwe and South Sudan. Given this mixed record, it is not surprising that scholars disagree as to whether power sharing actually reduces conflict. Based on systematic data and innovative methods, this book comes to a mostly positive conclusion by focusing on practices rather than merely formal institutions, studying power sharing's preventive effect, analyzing how power sharing is invoked in anticipation of conflict, and by showing that territorial power sharing can be effective if combined with inclusion at the center. The authors' findings demonstrate that power sharing is usually the best option to reduce and prevent civil conflict in divided states.
Sexual Assault on Campus
Authors: Lave Tamara Rice
Published: June 2022

Fair adjudication of campus sexual assault is one of the most divisive issues facing the United States. Victims contend that schools aren't doing enough to protect them, and accused students complain that they are presumed guilty. Sexual Assault on Campus: Defending Due Process begins by critically assessing the extent of the problem, before explaining why the criminal justice system has been unable to respond adequately. The book discusses the Department of Education's attempts to force schools to take campus assault seriously and uses original data in assessing the fairness of adjudication in the wake of the 2011 'Dear Colleague Letter.' It also includes excerpts from interviews with complainants, accused students, and administrators, which offer readers a first-hand account of these proceedings. Finally, the book provides a critical, in-depth look at the Title IX regulations put in place by the Trump Administration, with detailed recommendations for how they can be improved.
Methicillin-resistant Staphylococcus aureus nasal colonization in children with cerebral palsy
Authors: Schaps Diego , Dever Reilly , Parente Victoria M. , Anderson Deverick J. , Kalu Ibukunoluwa C.
Published: June 2022

A retrospective cohort of children admitted to the pediatric intensive care unit (PICU) with cerebral palsy was matched 1:3 by age and admission year to determine odds of methicillin-resistant Staphylococcus aureus (MRSA) nasal colonization. Adjusted odds of MRSA nasal colonization at PICU admission were 2.6-fold higher among children with cerebral palsy.
Contribution of base diet, voluntary fortified foods and supplements to micronutrient intakes in the UK
Authors: Bird Julia K. , Barron Rebecca , Pigat Sandrine , Bruins Maaike J.
Published: June 2022

The objective of the present study was to evaluate the contribution of voluntary fortified foods and supplements to reducing micronutrient shortfalls in the UK population. A secondary analysis of the UK National Diet and Nutrition Survey was conducted (2012/13–2013/14,N2546, 1·5–95 years). Micronutrient intakes were derived from food consumption intake data and food composition data and calculated as the proportion below or above the Dietary Reference Values for males and females of different age groups, for those on a base diet only, users of fortified foods but no supplements and users of fortified foods and supplements. Of the population consuming a base diet only, 21–45 % and 5–29 % fell below the Estimated Average Requirement (EAR) for minerals and vitamins, respectively. About 3–13 % fewer consumers of fortified foods fell below the EAR for vitamins and minerals. Supplements barely reduced the prevalence of intakes below the EAR. Among supplement non-users and users, 99 and 96 % failed to meet the reference intakes for vitamin D. More women than men were at risk of inadequacies of micronutrient intakes. The prevalence of inadequacies declined with increasing age. Voluntary fortified foods but not supplements made a meaningful contribution to intakes of vitamin and minerals, without risk of unacceptably high intakes. These insights may help the UK to define approaches to address micronutrients of concern in vulnerable groups.
Double-Edged Bullets: The Conditional Effect of Terrorism on Vote for the Incumbent
Authors: Falcó-Gimeno Albert , Muñoz Jordi , Pannico Roberto
Published: June 2022

Terrorism often seeks to impact democratic politics. This article explores how it can influence the electoral fortunes of the incumbent. Existing research is contradictory. Models of retrospective voting predict a negative impact, as terrorism is detrimental to voters' welfare. However, the well-known ‘rally around the flag’ effect suggests otherwise: following a terrorist attack, voters often cling to the incumbent. We reconcile these arguments and argue that while both effects can coexist, the retrospective assessment is more durable than the rally around the flag. Using data on all deadly domestic terrorist attacks in Spain between 1977 and 2008, matched with municipal-level national election results, we show how exposure to strikes that occur during the last quarter of the term benefit the incumbent, while more temporally distant attacks are electorally harmful. In line with our theory, we find a more pronounced temporal heterogeneity for indiscriminate attacks and those that target civilians.
Nitrogen and trinexapac-ethyl effects on wheat grain yield, lodging and seed physiological quality in southern Brazil
Authors: Faria Lucas Pinto de , Silva Sérgio Ricardo , Lollato Rômulo Pisa
Published: June 2022

Nitrogen (N) fertilization affects wheat yield and grain protein concentration; however, its mismanagement can increase plant lodging. While the use of plant growth regulators such as trinexapac-ethyl (TE) can mitigate plant lodging, their effects on seed physiological quality are not well known. The aim of this study was to evaluate the effects of N fertilization and TE on wheat yield, lodging and seed quality of spring wheat varieties. It was carried out in the 2018 growing season in the environments of Londrina and Ponta Grossa, Brazil. A randomized complete block design was used with a 2 × 3 × 3 factorial arrangement to evaluate two wheat genotypes (WT 15008 and WT 15025), three top-dressing N rates (0, 40 and 120 kg ha−1), and three TE rates (0, 50 and 100 g ha−1). Agronomic characteristics related to wheat productivity (hectolitre weight, thousand-grain weight, density of fertile spikes, plant height, lodging and grain yield) and seed physiological quality (seed germination and vigour; length and dry matter of normal seedlings) were evaluated. Increasing N rates up to 120 kg ha−1 increased plant lodging up to 26.4 percentage points for WT 15025 in Londrina. TE impaired some traits of seed physiological quality. Spraying 100 g ha−1 TE on the plants reduced seedling length by 9.4% in the seeds of WT 15008 harvested in Ponta Grossa compared to the TE control (0 g ha−1). The dry matter of the seedlings from the seeds harvested in Londrina declined by 7.2% due to the application of 100 g ha−1 TE, compared to the control. However, a lower rate of TE (50 g ha−1) might be enough to minimize plant lodging without impairing the physiological quality of the seeds, depending on the rate of N fertilization. This study is the first step in providing empirical evidence for the detrimental effects of TE in combination with N on wheat seed quality, suggesting that seed producers should exercise caution in managing TE and N fertilization.
Effect of sainfoin (Onobrychis viciifolia) on cyathostomin eggs excretion, larval development, larval community structure and efficacy of ivermectin treatment in horses
Authors: Malsa Joshua , Courtot Élise , Boisseau Michel , Dumont Bertrand , Gombault Pascale , Kuzmina Tetiana A. , Basiaga Marta , Lluch Jérôme , Annonay Gwenolah , Dhorne-Pollet Sophie , Mach Nuria , Sutra Jean-François , Wimel Laurence , Dubois Cédric , Guégnard Fabrice , Serreau Delphine , Lespine Anne , Sallé Guillaume , Fleurance Géraldine
Published: June 2022

Alternative strategies to chemical anthelmintics are needed for the sustainable control of equine strongylids. Bioactive forages like sainfoin (Onobrychis viciifolia) could contribute to reducing drug use, with the first hints of in vitro activity against cyathostomin free-living stages observed in the past. We analysed the effect of a sainfoin-rich diet on cyathostomin population and the efficacy of oral ivermectin treatment. Two groups of 10 naturally infected horses were enrolled in a 78-day experimental trial. Following a 1-week adaptation period, they were either fed with dehydrated sainfoin pellets (70% of their diet dry matter) or with alfalfa pellets (control group) for 21-days. No difference was found between the average fecal egg counts (FECs) of the two groups, but a significantly lower increase in larval development rate was observed for the sainfoin group, at the end of the trial. Quantification of cyathostomin species abundances with an ITS-2-based metabarcoding approach revealed that the sainfoin diet did not affect the nemabiome structure compared to the control diet. Following oral ivermectin treatment of all horses on day 21, the drug concentration was lower in horses fed with sainfoin, and cyathostomin eggs reappeared earlier in that group. Our results demonstrated that short-term consumption of a sainfoin-rich diet does not decrease cyathostomin FEC but seems to slightly reduce larval development. Consumption of dehydrated sainfoin pellets also negatively affected ivermectin pharmacokinetics, underscoring the need to monitor horse feeding regimes when assessing ivermectin efficacy in the field.
The Persian version of Herth Hope Index in Iranian patients with cancer: A psychometric study
Authors: Sharif Nia Hamid , Moshtagh Mozhgan , Khoshnavay Fomani Fatemeh , She Long , Kohestani Daniyal , Rahmatpour Pardis , Keeton William
Published: June 2022

Objectives

Hope is a contextual concept that has significant effects on human well-being. This study aimed to evaluate the psychometric properties of the Persian version of the Herth Hope Index (P-HHI) among Iranian patients with cancer.

Method

This cross-sectional study was conducted on 320 patients with cancer from September to December 2020. After translating the HHI into Persian, content, convergent and discriminant, construct validity (exploratory and confirmatory factor analysis), and reliability of the P-HHI were assessed.

Results

The results of exploratory factor analysis showed that the P-HHI was composed of two factors: Life Expectancy and Thinking Positive, which explained 55.20% of the total variance.

Significance of results

The research revealed that the P-HHI has acceptable validity and reliability, which can be used to measure the hope concept among Iranian patients with cancer.
Male intake of omega-3 fatty acids and risk of intimate partner violence perpetration: a nationwide birth cohort – the Japan Environment and Children's Study
Authors: Matsumura Kenta , Hamazaki Kei , Tsuchida Akiko , Inadera Hidekuni ,   the Japan Environment and Children's Study (JECS) Group
Published: June 2022

Aims

Intake of omega-3 polyunsaturated fatty acids (PUFAs) has favourable effects on reducing aggressive and violent behaviours, but its association with perpetration of intimate partner violence (IPV) is not known. We aimed to determine the association between male intake of omega-3 PUFAs and risk of IPV perpetration.

Methods

Participants were male–female pairs in the Japan Environment and Children's Study, in which first pregnant women and then their partners were enrolled (analytic sample: n = 48 065). Male intake of omega-3 PUFAs during the past year (preconception to mid/late pregnancy) was determined using a food frequency questionnaire. IPV (physical violence and emotional abuse) during pregnancy was measured using a self-reported questionnaire completed by pregnant women in mid/late pregnancy. Generalised additive mixed-model analysis was used to examine the non-linear association between energy-adjusted male omega-3 PUFA intake and the adjusted prevalence of male IPV perpetration.

Results

A sharply decreasing regression curve was plotted for physical violence, with prevalence starting at 1.35% at the lowest intake level and decreasing to a minimum value of 0.76% at intake of 2.20 g/day (71.7th percentile). However, prevalence largely remained flat from there onward, with the upper limit of the error range not reaching the initial lower limit of the error range until intake exceeded 5.21 g/day (99.77th percentile). For emotional abuse, on the other hand, there was a distorted U- or V-shaped regression curve that rose slightly after reaching a minimum. The prevalence declined from 17.69% initially, reached a minimum at 12.44% at 2.13 g/day (68.3th percentile), and then rose slightly. The lower limit of the error range reached the minimum upper limit at 4.17 g/day (99.1th percentile), and the upper limit finally reached the maximum lower limit value at 4.56 g/day (99.5th percentile).

Conclusions

In this nationwide birth cohort study, higher male intake of omega-3 PUFAs was associated with lower risk of physical violence and emotional abuse perpetration except for extremely high intake. Our results indicate the potential applicability of omega-3 PUFAs in reducing aggressive and violent behaviours in IPV.

Trial registration: UMIN000030786.
Music Workshops as Social Aesthetic Contributions to Cultivating Community Sensibilities
Authors: Andriolo Arley , Hodgetts Darrin James , Sonn Christopher C. , Valentim Teixeira Coelho Cecília Maria , Petraglia Marcelo Silveira
Published: June 2022

Abstract. Human connection and mutual exploration through engagements in the arts, in general, and music, more specifically, have been core features of community life in many settings for millennia. The importance of such modes of collective engagement has also gained renewed interest among psychologists. This article explores the use of arts-based practice in Brazilian organizational settings. Embracing the theoretical perspective of the bricoleur, we adopt a social aesthetic perspective as a basis for considering the cultivation of a sense of community and togetherness through music workshops. Our focus is on shifts in the social sensibilities of participants as they engage with each other through music. This article contributes to qualitative research in community and critical social psychology, where a turn to community arts is gaining increasing traction.
Mysteries of the Global Carbon Cycle
Authors: Crisp David , Dolman Han , Tanhua Toste , McKinley Galen , Hauck Judith , Bastos Ana , Sitch Stephen
Published: June 2022

Less than half of the anthropogenic carbon dioxide remains in the atmosphere to drive climate change. The rest is being removed by mysterious processes in the land, biosphere, and ocean.
Mega‐Depressions on the Cocos Ridge: Links Between Volcanism, Faults, Hydrothermal Circulation, and Dissolution
Authors: Kluesner Jared W. , Silver Eli A. , Bangs Nathan L. , Ranero César R. , Nale Stephanie , Gibson James , McIntosh Kirk D.
Published: June 2022

High‐resolution bathymetry and three‐dimensional seismic data along the Cocos Ridge reveal a 245 km2 field of ∼1–4 km in diameter seafloor depressions. The seafloor depressions are part of a two‐tiered honeycomb pattern. The lower‐tier depressions have steep faults that truncate strata with chaotic internal reflections consistent with sediment collapse into the depression. These extend into a lens shaped interval just above igneous basement. Overlying these depressions is a second broader set with rough seafloor morphology with gently dipping boundaries defined by pinch‐out stratigraphic patterns. Drilling results indicate that the lens‐shaped zones that host the deeper depressions represent anomalous regions of high porosity, low velocity, and low density within calcareous rich sediment. Analysis of nannofossils from IODP Site U1414 suggests the collapse structures formed during the late Miocene, whereas the younger shallower depressions likely formed between the early Pliocene and the Pliocene‐Pleistocene boundary. Geochemical and petrological analysis at Site U1414 suggests that hydrothermal circulation during the late Miocene led to carbonate dissolution and collapse. Following collapse, focused fluid‐flow and bottom current scouring resulted in formation of the overlying set of depressions and a honeycomb seafloor morphology. Similar sets of depressions along the Carnegie Ridge to the south support the hypothesis that two‐tiered depressions formed in response to processes that occurred broadly across the Panama Basin between the late Miocene and the Pliocene‐Pleistocene transition. Geochemical results at Site U1414, combined with geophysical data, suggest this two‐tiered system of depressions currently guides ongoing fluid outflow.