Supplementary Tables 1 - 18 from KLF5 Regulates the Integrity and Oncogenicity of Intestinal Stem Cells
Authors: Nakaya Takeo , Ogawa Seishi , Manabe Ichiro , Tanaka Masami , Sanada Masashi , Sato Toshiro , Taketo Makoto M. , Nakao Kazuki , Clevers Hans , Fukayama Masashi , Kuroda Masahiko , Nagai Ryozo 
Published: March 2023

<p>XLS file - 1363KB, Supplementary Table 1. Genes downregulated following the inducible deletion of Klf5 in the duodenal stem cells of Lgr5-EGFP-ires-CreERT2 Catnblox(deltaex3) Klfflox/flox mice, compared with Lgr5-EGFPires-CreERT2 atnblox(deltaex3) Klf5+/+ mice, under simultaneous induction of an active mutant of Catnb. Supplementary Table 2. Genes upregulated following the inducible deletion of Klf5 in the duodenal stem cells of Lgr5-EGFP-ires-CreERT2 Catnblox(deltaex3) Klf5flox/flox mice, compared with Lgr5-EGFPires-CreERT2 Catnblox(deltaex3) Klf5+/+ mice, under simultaneous inductions of an active mutant of Catnb. Supplementary Table 3. Genes downregulated following the inducible deletion of Klf5 in the duodenal TA cells of Lgr5-EGFP-ires-CreERT2 Catnblox(deltaex3) Klf5flox/flox mice, compared with Lgr5-EGFPires-CreERT2 Catnblox(deltaex3) Klf5+/+ mice, under simultaneous induction of an active 6 mutant of Catnb. Supplementary Table 4. Genes upregulated following the inducible deletion of Klf5 in the duodenal TA cells of Lgr5-EGFP-ires-CreERT2 Catnblox(deltaex3) Klf5flox/flox mice, compared with Lgr5-EGFPires-CreERT2 Catnblox(deltaex3) Klf5+/+ mice, under simultaneous induction of an active mutant of Catnb. Supplementary Table 5. Genes downregulated following the inducible deletion of Klf5 in both duodenal stem cells and TA cells of Lgr5-EGFP-ires-CreERT2 Catnblox(deltaex3) Klf5flox/flox mice, compared with Lgr5-EGFP-ires-CreERT2 Catnblox(deltaex3) Klf5+/+ mice, under simultaneous induction of an active mutant of Catnb. Supplementary Table 6. Genes upregulated following the inducible deletion of Klf5 in both duodenal stem cells and TA cells of Lgr5-EGFP-ires-CreERT2 Catnblox(deltaex3) Klf5flox/flox mice, compared with Lgr5-EGFP-ires-CreERT2 Catnblox(deltaex3) Klf5+/+ mice, under simultaneous induction of an 7 active mutant of Catnb. Genes with fold change in expression (Lgr5 Cre+ Catnblox(deltaex3) Klf5delta/delta / Lgr5 Cre+ Catnblox(deltaex3) Klf5+/+) > 2 are listed in alphabetical order of official gene symbol. Supplementary Table 7. Genes downregulated following the inducible deletion of Klf5 in the duodenal stem cells of Lgr5-EGFP-ires-CreERT2 Klf5delta/delta mice, compared with Lgr5-EGFP-ires-CreERT2 Klf5flox/flox mice. Supplementary Table 8. Genes upregulated following the inducible deletion of Klf5 in the duodenal stem cells of Lgr5-EGFP-ires-CreERT2 Klf5delta/delta mice, compared with Lgr5-EGFP-ires-CreERT2 Klf5flox/flox mice. Supplementary Table 9. Genes downregulated following the inducible deletion of Klf5 in the duodenal TA cells of Lgr5-EGFP-ires-CreERT2 Klf5delta/delta mice, compared with Lgr5-EGFP-ires-CreERT2 Klf5flox/flox mice. Supplementary Table 10. Genes upregulated following the inducible deletion of Klf5 in the duodenal TA cells of Lgr5-EGFP-ires-CreERT2 Klf5delta/delta mice, compared with Lgr5-EGFP-ires-CreERT2 Klf5flox/flox mice. Supplementary Table 11. Genes downregulated following the inducible deletion of Klf5 in both duodenal stem cells and TA cells of Lgr5-EGFP-ires-CreERT2 Klf5delta/delta mice, compared with Lgr5-EGFPires-CreERT2 Klf5flox/flox mice. Supplementary Table 12. Genes upregulated following the inducible deletion of Klf5 in both duodenal stem cells and TA cells of Lgr5-EGFP-ires-CreERT2 Klf5delta/delta mice, compared with Lgr5-EGFPires-CreERT2 Klf5flox/flox mice. Supplementary Table 13. Genes downregulated following the inducible deletion of Klf5 in both duodenal stem cells and TA cells of Lgr5-EGFP-ires-CreERT2 Catnblox(deltaex3) Klf5flox/flox mice, compared with Lgr5-EGFP-ires-CreERT2 Catnblox(deltaex3) Klf5+/+ mice, under the simultaneous inductions 9 of an active mutant of Catnb, as well as downregulated in both duodenal stem cells and TA cells of Lgr5-EGFP-ires-CreERT2 Klf5delta/delta mice, compared with Lgr5-EGFP-ires-CreERT2 Klf5flox/flox mice, without induction of the active mutant of Catnb. In other words, the genes with all fold changes < 0.5 are listed. Supplementary Table 14. Genes upregulated following the inducible deletion of Klf5 in both duodenal stem cells and TA cells of Lgr5-EGFP-ires-CreERT2 Catnblox(deltaex3) Klf5flox/flox mice, compared with Lgr5-EGFP-ires-CreERT2 Catnblox(deltaex3) Klf5+/+ mice, under the simultaneous inductions of an active mutant of Catnb, as well as downregulated in both duodenal stem cells and TA cells of Lgr5-EGFP-ires-CreERT2 Klf5delta/delta mice, compared with Lgr5-EGFP-ires-CreERT2 Klf5flox/flox mice, without induction of the active mutant of Catnb. In other words, the genes with all fold changes > 2 are listed. Supplementary Table 15. MicroRNAs downregulated following the inducible deletion of Klf5 in the duodenal stem cells of Lgr5-EGFP-ires-CreERT2 Catnblox(deltaex3) Klf5flox/flox mice, compared with Lgr5-EGFP-ires-CreERT2 Catnblox(deltaex3) Klf5+/+ mice, under simultaneous induction of an active mutant of Catnb. MicroRNAs with fold change in expression (Lgr5 Cre+ Catnblox(deltaex3) Klf5delta/delta / Lgr5 Cre+ Catnblox(deltaex3) Klf5+/+) < 0.5 are listed in order of ascending fold change. Supplementary Table 16. Supplementary Table S16. MicroRNAs upregulated following the inducible deletion of Klf5 in the duodenal stem cells of Lgr5-EGFP-ires-CreERT2 Catnblox(deltaex3) Klf5flox/flox mice, compared with Lgr5-EGFP-ires-CreERT2 Catnblox(deltaex3) Klf5+/+ mice, under simultaneous inductions of an active mutant of Catnb. Supplementary Table 17. MicroRNAs downregulated following the inducible deletion of Klf5 in the duodenal stem cells of Lgr5-EGFP-ires-CreERT2 Klf5delta/delta mice, compared with Lgr5-EGFP-ires-CreERT2 Klf5flox/flox mice. Supplementary Table 18. MicroRNAs upregulated following the inducible deletion of Klf5 in the duodenal stem cells of Lgr5-EGFP-ires-CreERT2 Klf5delta/delta mice, compared with Lgr5-EGFP-ires-CreERT2 Klf5flox/flox mice.</p>