bluuebunny/crossref_metadata_2025 huggingface dataset:
Pelatihan Akuntansi dan Pelatihan Penggunaan Bahan Pengawet kepada Pengusaha Home Industri Roti Kacang
Authors: Nasution Ilham Ramadhan , Sartini Sartini
Published: March 2020

Kemajuan suatu usaha tergantung pada mau atau tidaknya mengadopsi suatu teknologi. Jika tidak mengikuti perkembangan teknologi maka akan tertinggal dan jika mengikutinya maka akan maju bersaing. Namun, adakalanya keinginan untuk hijrah mengikuti perkembangan jaman dari tradisional menjadi modern tidak disertai dukungan dari tenaga ahli  sehingga dalam prakteknya pelaku pengusaha mencoba-coba sendiri tanpa perhitungan yang jelas, alhasil konsumen menjadi kelinci percobaannya dari ketidaktahuannya. Seperti pada pengabdian kali ini, pengusaha roti kacang selama 10 tahun berdiri tidak mengalami kemajuan dalam usahanya, berbagai masalah turut mengambil andil dalam mempengaruhi keuntungan penjualan seperti masalah harga bahan baku untuk pembuatan roti kacang yang tidak stabil, kapasitas kemampuan dalam memproduksi roti kacang setiap harinya terbatas, masa kadaluarsa yang terlalu cepat, kemasan yang tidak menarik dan tidak memenuhi syarat untuk memperoleh bantuan modal dari bank karena tidak mempunyai buku laporan keuangan perusahaan. Dari masalah  diatas penulis ingin memberikan solusi  dengan melakukan kegiatan pengabdian kepada masyarakat.Solusi yang ditawarkan adalah memberikan pemahaman tentang bahan pengawet serta pelatihan penggunaan bahan pengawet untuk memperpanjang masa kadaluarsa, melakukan pelatihan dalam penyusunan laporan keuangan dan memberikan design kemasan produk yang menarik. Diharapkan dengan melakukan kegiatan pengabdian kepada masyarakat ini usaha mitra dapat berkembang.
Penyidikan Tindak Pidana Pemilihan Umum Gubernur dan Wakil Gubernur Sumatera Utara Tahun 2018
Authors: Lubis Agustami , Eddy Triono , Mulyadi Mahmud
Published: March 2020

Pemilihan gubernur dan wakil gubernur Sumatera Utara pada tahun 2018 merupkan proses memilih orang untuk menduduki jabatan melalui mekanisme dan proses demokrasi yang jujur dan adil. Dalam proses pelaksanaan pemilu pemilu banyak terjadi pelanggaran-pelanggaran baik pelanggaran bersifat administrasi, maupun bersifat tindak pidana. Penelitian ini bertujuan untuk untuk menganalisis pengaturan tindak pidana pemilu pada pemilihan gubernur dan wakil gubernur propinsi Sumatera Utara menurut UU No. 10 Tahun 2016. Pasangan calon Jopinus Ramli (JR) Saragih dan Ance Selian yang dibatalkan KPU propinsi terkait tindak pidana dalam bentuk pidana pemalsuan surat dokumen, sebagaimana disebutkan dalam Pasal 184 dengan UU No. 10 Tahun 2016 tentang Pemilihan Gubernur, Bupati, dan Walikota, dan mengetahui proses penyidikan tindak pidana pemilihan umum gubernur dan wakil gubernur provinsi Sumatera Utara. Hasil penulisan ini menunjukan bahwa peraturan dalam tindak pidana pemilu gubernur dan wakil gubernur merujuk pada UU No. 10 Tahun 2016 dan proses penyelidikan oleh Kepolisian atas temuan BAWASLU menunjukan bukti-bukti, fakta hukum dan saksi yang menyimpulkan terjadinya tindak pidana pemalsuan dokumen dan KPU membatalkan pasangan calon Jopinus Ramli (JR) Saragih dan Ance Selian.
Perlindungan Hukum terhadap Masyarakat Muslim Kota Medan tentang Produk Makanan Halal (Studi Proses Sertifikasi Halal Oleh Majelis Ulama Indonesia Kota Medan)
Authors: Tarigan Azhari Akmal , Isnaini Isnaini , Tuahman Tuahman , Nasution Indra Kurniawan
Published: March 2020

Tujuan penelitian ini adalah bagaimana perlindungan hukum terhadap masyarakat muslim Kota Medan tentang produk makanan halal, proses pensertifikasian di Majelis Ulama Indonesia Kota Medan dan implementasi sertifikasi Halal MUI Kota Medan. Jenis penelitian yang digunakan adalah penelitian hukum normatif, yaitu dilakukan dengan cara meneliti bahan pustaka atau sekunder yang terdiri dari bahan hukum primer, bahan hukum sekunder dan bahan hukum tersier. Analisis data yang digunakan dengan analisis kualitatif. Perlindungan hukum kepada masyarakat muslim Kota Medan terhadap Jaminan Produk Halal diatur dalam Undang-Undang Nomor 18 tahun 2012 tentang Pangan, Undang-Undang Nomor 33 tahun 2014 tentang Jaminan Produk Halal, Peraturan Pemerintah Nomor 69 tahun 1999 tentang Label dan Iklan Pangan, serta di dalam Undang-Undang Nomor 8 tahun 1999 tentang Perlindungan Konsumen dan adanya sertifikat halal yang dikeluarkan oleh MUI Kota Medan. Hambatan dalam menjaga kepastian hukum terhadap makanan halal bagi masyarakat muslim Kota Medan diantaranya adalah lemahnya koordinasi antara Pemerintah kota Medan dan MUI Kota Medan dan belum adanya peraturan pelaksanan terkait undang-undang jaminan produk halal, serta masih kurangnya sosialisasi yang dilakukan terkait jaminan produk halal kepada masyarakat. Hambatan eksternal berasal dari masyarakat dan pelaku usaha belum ada kesadaran masyarakat dan pelaku usaha untuk melakukan pendafataran sertifikasi halal.
Peran Akademisi dalam Mencegah Peredaran Narkotika di Masyarakat (Sosialisasi Desa Bandar Baru Kecamatan Sibolangit Kabupaten Deli Serdang Provinsi Sumatera Utara)
Authors: Lubis M. Faisal Rahendra
Published: March 2020

Tujuan penelitian ini adalah untuk menganalisis peran akademisi dalam Pencegahan, penanggulangan penyalahgunaan, dan peredaran gelap narkoba. Harapannya, dapat terwujud stabilitas pembangunan nasional, masyarakat adil, makmur, dan sejahtera. Banyak upaya pemulihan namun keberhasilannya sendiri sangat bergantung pada sikap profesionalisme lembaga yang menangani program rehabilitasi ini, kesadaran dan kesungguhan penderita untuk sembuh serta dukungan kerja sama antara penderita, keluarga dan lembaga. Masalah yang paling sering timbul dan sulit sekali untuk dihilangkan adalah mencegah datangnya kembali kambuh (relaps) setelah penderita menjalani pengobatan. Untuk itu para aktivis di lingkungan kampus, diharapkan lebih meningkatkan perannya dalam memerangi penyalahgunaan narkoba melalui kegiatan dan aktivitas Anti-Narkoba baik pada tataran ilmiah maupun pada tataran praktik di lapangan, membentuk kelompok-kelompok pendidik sebaya yang bertugas membantu mensosialisasikan bahaya penyalahgunaan narkoba dan mendorong terbentuknya aktifitas dalam kampus, seperti halnya pengembangan pusat informasi dan konseling masalah penyalahgunaan narkoba
HPV TESTING IN CERVICAL CANCER PREVENTION
Authors: Nguyen Vu Quoc Huy
Published: March 2020

Despite the introduction of HPV vaccines and its clinical application expanded during the last decade with increasing vaccine coverage, cervical cancer prevention still requires continuing and widespread screening activity. Based on the knowledge about the impact of HPV on cell cycle control mechanisms, tests for detection of HPV DNA, host cellular proteins or HPV proteins have been developed and introduced to clinical application. Among them, tests able to detect DNA of high-risk HPVs have been widely used worldwide and start to be evidenced as a valuable screening test in cervical cancer prevention. Hybrid Capture II (HCII, Qiagen, USA) using DNA hybridization and signals amplification technique is the FDA and EC approved test, which can detect and differentiated any type from 13 high-risk HPV types (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59 and 68) and 5 low-risk HPV types (6, 11, 42, 43, 44). The introduction of a newly developed HPV test using simpler technology and affordable cost - careHPV - and its commercialization in the very near future, in combination with visual inspection with acetic acid and/or colposcopy will allow the implementation of new approaches with higher coverage and a more effective strategy of screening – diagnosis – management.
UPDATE ON THE DIAGNOSIS AND TREATMENT OF RHEUMATOID ARTHRITIS
Authors: Nguyen Hoang Thanh Van
Published: March 2020

Rheumatoid Arthritis (RA) is a chronic inflammation disease chracterized by swelling, tenderness joint and destruction of synovial joints, leading to severe disability and premature mobility. So, ACR/EULAR 2010 has presented some tools to assessing disease activity and a new classification criteria for an early diagnosis and treatment. However, this is not a gold criteria to diagnose RA. Pharmacological treatment should not just comprise anti-inflammatory agents and corticosteroid. The current therapeutic approach is to start elder DMARDs and biologic agents. The RA patients is selected carefully before using and following side effect of these agents.
CLINICAL, BIOCHEMICAL AND VIRAL RESPONSES AFTER 12 MONTH-TENOFOVIR TREATMENT IN PATIENTS WITH CHRONIC HEPATITIS B
Authors: Tran Van Huy , Nguyen Hoai Phong
Published: March 2020

Objectives: To evaluate the initial results of tenofovir in chronic hepatitis B patients with clinical change, rate of ALT change, HBeAg seroconversion and HBV DNA change after 12 months and determine virus break throught rate and side effects of tenofovir. Subjects and Methods: prospective study, open label, uncontrolled. Subjects: 75 Patients with chronic hepatitis B were enrolled in this study, treated with tenofovir in 12 months at Hue Medical University Hospital from 11/2010 to 8/2012. Results: The rate of ALT normalization is 77.3% after 6 months, 89.3% after 12 months. HBeAg loss rate is 22% after 6 months and 68.3% after 12 months. HBeAg seroconversion rate is 12.2% after 6 months and 29.3% after 12 months. HBV DNA-negative rate after 12 months is 84%. Low rate of side effects and not detected viral break-out. Conclusion: Tenofovir may be an effective and safe agent in patients with chronic hepatitis B.
STUDY ON SERUM FERRITIN CONCENTRATION IN STROKE PATIENTS
Authors: Nguyen Huynh Hanh Trinh , Nguyen Viet Quang , Hoang Khanh
Published: March 2020

Purpose:
1. Determined the elevated serum ferritin levels in patients with cerebral infarction and cerebral hemorrhage.
2. Determined the correlation between ferritin and Glasgow scale and volume of lesions.
Subjects and methods: Select 63 randomized stroke patients. Glasgow scale assessment at admission. The volume of lesions identified on cranial CT scan according to the formula 0.5 abc (a, b: the size of the lesion on the slice; c: number of slices of the lesion on CT). Quantified by measuring the turbidity ferritin. Data processing: comparing two rates by c2; mean by T-test; linear correlation with the Pearson correlation coefficient rp.
Results: The average concentration of ferritin: 341.28 ± 198.97 ng / mL; males: 396.84 ± 175.46 ng/mL, in females: 276.13 ± 207.93 ng/mL (p <0.05); Cerebral hemorrhage: 353.36 ± 176.07 ng/mL, Cerebral infarction: 332.79 ± 215.58 ng / mL (p> 0.05). The relationship between ferritin and Glasgow: r = -0.258, p <0.05; males: r = -0.123, p> 0.05; female: r = -0.369, p <0.05. The relationship between ferritin and lesion volume: r = 0.291, p <0.05; males: r = 0.119, p> 0.05; female: r = 0.395, p <0.05.
Conclusion: Serum ferritin increased in cerebral hemorrhage 61.54%, cerebral infarction 59.46%. There is a weak correlation between serum ferritin levels and the severity of the disease on a scale of Glasgow and brain lesion volume. Keywords: Stroke, cerebral infarction, cerebral hemorrhage, serum ferritin, Glasgow scale, the volume of lesions.
SUGGESTION A SIMPLE SCREENING SCORE FOR PRE-DIABETES AND UNDIAGNOSED TYPE 2 DIABETES FOR THE VIETNAM POPULATION
Authors: Nguyen Van Vy Hau , Nguyen Hai Thuy
Published: March 2020

Objectives: We suggested and validated a self-assessment score for diabetes risk in Vietnamese adults and compared it with other established screening models.
Methods: A cross sectional study of 131 subjects (over 45 years old without previous diabetes) were performed the test FPG, HbA1c and oral glucose tolerance tests, and then applied the diabetes risk scores including FINDRISC, IDRS, FRAMINGHAM OFFSPRING, THAI SCORE, DESIR and AUSDRISC for predicting the type 2 diabetes mellitus and screening to prediabetes and undiagnosed diabetes. Logistic regression was used to determine the independent factors concerning diabetes.
Results: The FINDRISC tool was more valuable for screening of the type 2 prediabetes and diabetes than the other scales. With plasma G2 levels ≥ 7.8 mmol: ROC-UAC of FINDRISC was 61.2%, the optimal cut points: 12 (Se = 32.7%; 1-Sp = 7.4%); with plasma G2 concentration ≥ 11.1 mmol: ROC-AUC of FINDRISC was 89.3%, the optimal cut point of 13 (Se = 90% 1-Sp = 22.3%). With HbA1c levels ≥ 5.7%: ROC-UAC was 76.3%, the optimal cut point of 9 (Se = 57.3%; 1-Sp = 7.1%), with HbA1c ≥ 6.5%: ROC-AUC was 86.7%, the optimal cut points: 13 (Se = 90.9%; 1-Sp = 21.7). Values for screening to prediabetes and diabetes in the VNDRISC 1 were 10 and 14 point and VNDRISC 2 were 12 and 16 point respectively, but the ROC-AUC of VNDRISC 2 was not significantly different than those VNDRISC 1.
Conclusions: FINDRISC have most valuable screening prediabetes and undiagnosed type 2 diabetes in social (when change body mass index and waist circumference follow Vietnamese people) compaired with others score. VNDRISC 1 was the most valuable diabetes risk score for predicting the type 2 diabetes mellitus and screening to prediabetes and diabetes in subjects over 45 years old on the community.
DETERMINATE OF SOME MAJOR CHEMICAL COMPOSITION IN SOME PLANT SPECIES THAT HAVE ANTIBACTERIAL ACTIVITY IN THUA THIEN HUE
Authors: Tran Dinh Binh , Nguyen Thi Hoai , Hoang Vinh Thong , Tran Thi Nhu Hoa , Huynh Thi Hai Duong , Le Nu Xuan Thanh
Published: March 2020

Objectives: To survey and select of medical plants that are capable of exploiting which determinated of their antibacterial activity and screened the initial characterization of the group of organic substances that have antibacterial effect.
Material and methods: Select the 18 medical plants species to screen antibacterial activity on a number of ATCC strains bacteria and the bacteria cause common diseases. One plant has no antibacterial effect used as the control sample that is yam. The selected plant species are 18 medicinal plants used in civil: Phyllanthus reticulatus Poir.; Hyptis brevipes Poit.; Celosia argentea L.; Vitex trifolia L. f. ; Aglaia duperreana Pierre; Bidens pilosa L.; Solanum torvum Swartz.; Heliotropium indicum L.; Chromolaena odorata (L) R.M.King & H.Bob.; Casuarina equisetifolia J.R et G. Forst.; Eichhornia crassipes (Maret) Solms ; Stachytarpheta jamaicensis (L.) Vahl.; Lantana camara L.; Ampelopsis brevipedunculata (Maxim.) Trautv.; Urena lobata L.; Caesalpinia pulcherrima (L.) Sw.; Scoparia dulcis L.; Streblus ilicifolius (Vidal). Determination of antibacterial activity of each extract by the method of antibiotic sensivity on the ATCC strains bacteria and the bacteria cause common diseases. Identification the group of organic substances by method of screening groups of natural compounds in plants by the characteristic chemical reactions.
Results and discussions: Selected some plants have the ability to exploit, can create an abundant raw materials, cheap and easely applying in local that have antibacterial activity. There are 6 medical plants which namely: Phyllanthus reticulatus Poir, Chromolaena odorata (L) R.M.King & H.Bob, Casuarina equisetifolia J.R et G. Forst, Ampelopsis brevipedunculata (Maxim.) Trautv, Urena lobata L, Kim phượng Caesalpinia pulcherrima (L.) Sw that have good antimicrobial activity. Many groups of organic compounds present in these medical plants participate in antibacterial activity as alkaloids, coumarin, flavonoids, heart glycosid, saponins, tannins... Some medical plants have enough of the organic compounds, but some contains only one or several organic compounds that have antibacterial properties.
Conclusions: Many groups of organic compounds present in these medical plants participate in antibacterial activity as alkaloids, coumarin, flavonoids, heart glycosid, saponins, tannins...
AN INTRODUCTION TO DATA CLUSTERING IN BIOINOFORMATICS
Authors: Nguyen Duc Tung , Nguyen Thi Le Thuy , Bui Le Thanh Nhan
Published: March 2020

Experimental methods for genome analysis are of crucial interest and have recently made a considerable progress. However, most complete orders of genomes have at least a half the number of gens with unexplicit note. There are some new trends of research in infomatics to deal with data clustering and treating. In this article, we introduce general data clustering and its application in Protein analysis, an initial step which is highly significant for the experimental study of gemone analysis. This method helps to reduce to number of prediction experiment and to perfect Protein function.
Key words: Cluster analysis, bioinformatics, Protein function prediction.
SCREENING OF STRAINS FOR ENANTIOSELECTIVE HYDROLYSIS OF RACEMIC MENTHYL BENZOATE TO PRODUCT L-MENTHOL
Authors: Ngo Thi Minh Thu , Zheng Gao-Wei , Xu Jian-He
Published: March 2020

Background: Because of pleasant flavor and aroma as well as cooling-anesthetic effect, menthol and mint oils are widely used in the flavor industry and biocatalytic processes for production of l-menthol are more interested nowadays. Herein, we attempted to develop a biocatalytic process for production of l-menthol through enantioselective hydrolysis of dl-menthyl benzoate using a strain newly isolated from soil.
Methods: From soil samples, we were isolated one strain exhibited the best hydrolytic activity and excellent enantioselectivity as compared to others. So, it was selected as the best enzyme producer and subsequently identified as Acinetobacter sp. based on the 99% similarity of its 16S rDNA sequence, and named Acinetobacter sp. ECU2040. The fermentation process was studied and the fermentation gave about 130 g wet cell, which was equivalent to 18 g dry cell. The catalytic properties of Acinetobacter sp. ECU2040 were also studied. The results showed that the optimum pH and temperature of reaction were 7.5 and 37ºC, respectively.
Results and conclusion: The strain Acinetobacter sp. ECU2040 strain exhibited the production of l-menthol ability with the best hydrolytic activity and excellent enantioselectivity.

Key words: l-menthol, enantioselective, isolated strain
THE RELATIONSHIP BETWEEN WEEKLY CLEARANCE OF UREA AND CREATININE IN END-STAGE RENAL DISEASE PATIENTS TREATED WITH CONTINUOUS AMBULATORY PERITONEAL DIALYSIS
Authors: Hoang Viet Thang
Published: March 2020

Backgrounds: The aims dialysis of any sort include maintenance of normal body fluid status, normal electrolyte and acid-base balance, and removal of waste products. The degree of adequacy of removing nitrogenous waste products is very important. So the aims of this study: calculating Kt/Vurea and CCr in end-stage renal disease patients treated by CAPD and evaluating the correlation between clearance of urea and creatinine.
Patients-Methods: 30 ESRD patients treated by CAPD at Department of Nephrology- Hue central Hospital were selected for this study from 1/2010 to 6/2011. The design of the study was a prospective crossover design.
Results: The mean age of the patients was: 36,17±10,74 years(male) and 49,07 ± 12,75 years (female). Weekly Kt/Vure/t at T0: 2,43 ± 0,86 and T9: 2,26 ± 0,75; Weekly CCr at T0: 95,45 ± 29,39 L/week/1,73 m2 and T9: 90,81 ± 27,44 L/week/l,73 m2, p > 0,05. There was a positive-relation between Kt/Vure/week) and (CCr/week), (r = 0,638; p < 0,05).
CONSTITUENTS OF N-HEXANE FRACTION EXTRACTED FROM UVARIA GRANDIFLORA COLLECTED FROM QUANG TRI PROVINCE
Authors: Le Thi Bich Hien , Le Thi Hong Oanh , Ho Viet Duc , Vo Quoc Hung , Nguyen Thi Hoai
Published: March 2020

Background: Today, conservation and development of indigenous knowledge of medicinal plants are the urgent demand of science. Uvaria grandiflora Roxb. ex Hornem which is used by medicinal experience of people of ethnic minorities in Quang Tri Province has shown in vitro cytotoxic activity in our previous screening tests. This article is an ongoing research to determine the chemical ingredients of this species.
Materials: The aerial parts of Uvaria grandiflora Roxb. ex Hornem were collected from Quang Tri Province.
Method: Fractional extraction was performed by using organic solvents. Volatile components were analysed by gas chromatography – mass spectrometry (GC-MS and indentified by comparison with published mass spectra database Wiley and NIST.
Results: Two major components are δ-cadinene (42.94%) and caryophyllene (9.51%). Some ingredients that consist of γ-muurolene, ar-curcumene, calarene, β-vetivenene, β-bisabolene, cadina-1,4-diene and calacorene have never been reported from U.grandiflora collected from Quang Tri province. According to others references, some of these compounds have abundant bioactivities such as antimicrobial, antioxidant, antiinﬂammatory activities, especially α-humulene and caryophyllene with anticancer activities in vitro. Fractional extraction was performed by using organic solvents. Volatile components were analysed by gas chromatography – mass spectrometry (GC-MS and indentified by comparison with published mass spectra database Wiley and NIST.
Conclusion: A total of sixteen volatile compounds were indentified in n-hexane fraction of Uvaria grandiflora Roxb. ex Hornem.

Key words: Uvaria grandiflora, δ-cadinene, α-humulene, caryophyllene
DETERMINATION OF P53 GENE CODON 72 POLYMORPHISMS IN PATIENTS WITH GASTRIC CANCER
Authors: Nguyen Thi Tuy Ha , Ha Thi Minh Thi
Published: March 2020

Background: The role of p53 gene in the gastric cancer is still controversial. This study is aimed at determining the rate of the p53 gene codon 72 polymorphisms in gastric cancer patients and evaluating the relationship between these polymorphisms and endoscopic and histopathological features of gastric cancer.
Patients and methods: Sixty eight patients with gastric cancer (cases) and one hundred and thirty six patients without gastric cancer (controls) were enrolled. p53 gene codon 72 polymorphisms were determined by PCR-RFLP technique with DNA extracted from samples of gastric tissue.
Results: In the group of gastric cancer, Arginine/Argnine, Arginine/Proline and Proline/Proline genotypes were found in 29.4%, 42.7% and 27.9%, respectively. The differences of rates were not statistically significant between cases and controls (p > 0,05). In males, the Proline/Proline genotype was found in 38.1% in patients with gastric cancer and more frequent in patients without gastric cancer (15.7%, p = 0,01). An analysis of ROC curve showed that the cut-off was the age of 52 in the Proline/Proline genotype, but it was 65 years old in the Arginine/Proline genotype. The Proline/Proline genotype was found in 41.9% in Borrmann III/IV gastric cancer, this rate was higher than Borrmann I/II gastric cancer (16.2%, p = 0.037) and also higher than controls (18.4%, p = 0,01). The rate of Proline/Proline genotype was 41.7% in the diffuse gastric cancer, it was higher than in controls (p = 0,023).
Conclusion: No significative difference of rate was found in genotypes between gastric cancer group and controls. However, there was the relationship between Proline/Proline genotype and gastric cancer in males, Borrmann types of gastric cancer, the diffuse gastric cancer.

Key words: polymorphism, codon 72, p53 gene, PCR - RFLP, gastric cancer.
DETECTING POINT MUTATIONS A2142G AND A2143G IN THE 23S RRNA GENE CAUSING HELICOBACTER PYLORI RESISTANCE TO CLARITHROMYCIN BY PCR RFLP
Authors: Ha Thi Minh Thi , Tran Van Huy
Published: March 2020

Background: Clarithromycine-resistance of H.pylori is one important cause of decreasing eradication rate of H.pylori. This study is aimed at:
(1): evaluating the application of PCR RFLP in detecting point mutations A2142G and A 2143G in the 23SrRNA gene resulting Clarithromycine-resistant H.pylori.
(2) determining the rate of these point mutations by PCR RFLP in patients with gastroduodenitis or peptic ulcers.
Patients and methods: 38 patients with gastroduodenitis or peptic ulcer were enrolled. H.pylori infection was confirmed by rapid Urease test and PCR. PCR was performed in two phases: amplification of gene 23S rRNA containing A2143 and A2142, followed by digestion of PCR products by enzymes BbsI and BsaI in order to detecting point mutations A2143G and A2142G. Different quantities of enzyme of digestion were evaluated (5U; 7,5U; 10U; 15U and 20U) in order to determine an optimal quantity.
Results: The components of digesting reaction were optimized as followings: performed in a solution volume of 20 µl, including 5 µl PCR products (to amplify gene 23S rRNA containing 2142 and 2143), 10 U enzyme (BsaI to detect A2143G, BbsI to detect A2142G), 2 µl buffer G 2X, and water for a sufficient volume. 17 point mutations A2143G were found (44.7%).
Conclusion: PCR RFLP could be routinely applied to detect point mutations A2143G and A2142G in the 23S rRNA gene causing clarithromycine-resistant H.pylori. The rate of these point mutations in this group of patients was relatively high.

Key words: Clarithromycin resistance, gene 23S rRNA, Helicobacter pylori
STUDY THE BLOOD LIPID CONCENTRATIONS AND HEPATIC STEATOSIS IN OVERWEIGHT-OBESE CHILDREN AGED 2-15 YEARS AT PEDIATRICS DEPARTMENT, HUE CENTRAL HOSPITAL
Authors: Nguyen Thi Cu
Published: March 2020

Background: Nowadays, childhood obesity is the 2nd priority health issue in the prevention and control of diseases in Asian countries. In Vietnam, obesity is alarming in children but not interested appropriately by the family and medical staff. Obesity and obesity-related conditions in adults are relatively studied frequently, however, in children they are much fewer and rather sporadic. There is evidence of a close association between obesity, dyslipidemia and hepatic steatosis in children; such disorders affect health, development and even lives of children. The aim of this study is to evaluate lipid profile and hepatic steatosis in overweight/obese children.
Subjects and Methods: Overweight/ obese children aged 2 to 15 years who had a clinic visit at the Pediatric Department, Hue Central Hospital from May 2011 to June 2012. 40 children with eligibility criteria were included in the study. Method: descriptive cross-sectional. Lipid profile and liver ultrasound in these children were done to evaluate the status of hepatic steatosis.
Results: There is a change in concentration of all lipid parameters in overweight/obese group compared to the control group. 37.5% of children with hypercholesterolemia; 50% of children with increased blood triglyceride, 25% of children with low blood levels of HDL-C; 17.5% of children with elevated blood LDL-C level. 40% of children with hepatic steatosis, mainly steatosis grade I (81.3%), and only one case of hepatic steatosis grade III (6.2%). Fatty liver ratio increased gradually with age but the difference was not statistically significant (p> 0.05). Central obese children showed a higher rate of fatty liver than peripheral obese children but there was no statistical significance. There is an association between blood levels of triglycerides, cholesterol and fatty liver.
Conclusion: The study showed disturbances in blood lipid concentrations and fatty liver in overweight/obese children, and a correlation between blood levels of triglyceride and cholesterol with fatty liver status.

Key words: overweight/obesity, hepatic steatosis, disturbances, blood lipids
TESTOSTERONE AND METABOLIC SYNDROME IN MEN
Authors: Nguyen Hai Thuy
Published: March 2020

Testosterone is vital hormone for men’s health and a keyplayer in glucose homeostasis, lipid metabolism, and cardiovascular pathology. Testosterone deficiency is associated with age, many chronic health conditions and other metabolic disorders. There is strong evidence that a low testosterone level has a high prevalence in men with metabolic syndrome. Many components of metabolic syndrome are adversely affected especially in relation to cardiovascular risk in the presence of hypogonadism.Testosterone deficiency is a risk factor in itself for the subsequent development of the metabolic syndrome. The hypothesis suggests that low testosterone as a result of high aromatase activity leads to a cycle which promotes increasing adipocyte number and fat deposition which gradually leads to a lower testosterone level. The hypogonadal-obesity-adipocytokine hypothesis explains why the body cannot respond to low testosterone levels by a compensatory production of the hormone. The interventional studies have shown that testosterone administration on hypogonadal men with metabolic syndrome has beneficial effects. These benefits have not only found that hypogonadal symptoms such as sexual function improve, but key metabolic markers also improve. It must also not be forgotten that testosterone replacement therapy in hypogonadal men with metabolic syndrome can have a major impact on the patient’s quality of life and well-being.

Key words: testosterone, metabolic syndrome.
IMPACT OF ESOPHAGEAL VARICEAL LIGATION COMBINED PROPRANOLOL ON PORTAL HYPERTENSIVE GASTROPATHY IN CIRRHOTIC PATIENTS
Authors: Tran Pham Chi
Published: March 2020

Objectives: 1. To investigate the prevalence of portal hypertensive gastropathy (PHG) and the ratio of mild/severe PHG. 2. The impact of esophageal variceal ligation (EVL) combined propranolol on the progress of PHG in terms of prevalence, distribution and severity. Patients and methods: Prospective, controlled study. Cirrhotic patients with the history of esophageal variceal bleeding or acute esophageal variceal bleeding in stable condition were devided into combined group: EVL combined propranolol (study group) and propranolol only (control group). Results: Sex ratio Male/Female: 82/4 = 20.5. Majority of cirrhotic etiology was alcohol: 73.3%. Esophageal varices grade II and III, no grade I. Prevalence of PHG: 90.7%, ratio of mild/ severe PHG: 12.8%/87.2%. The ratio, distribution and severity of PHG between the study group and control group after 3 and 6 months were not significantly different. Conclusions: 1. The prevalence of PHG: 90.7%, the ratio of mild/severe PHG: 12.8%/87.2%. 2. EVL combined propranolol did not change significantly the prevalence, distribution and severity ofPHG in comparison with propranolol group.

Key words: Cirrhosis, portal hypertensive gastropathy, esophageal variceal ligation, propranolol.
EVALUATION THE SURGICAL TREATMENT OF HEMORRHOID DISEASE BY TRANSANAL HEMORRHOIDAL DEARTERIALISATION (THD)
Authors: Nguyen Van Lieu , Nguyen Doan Van Phu , Nguyen Thanh Phuc
Published: March 2020

Introduction: Since 2006 Transanal hemorrhoidal dearterialization (THD), as a Doppler - guided Minimally Invasive Therapeutic Approach to Hemorrhoids, has been widely applied in European countries, America owing to its remarkable advantages over other surgical procedures such as less postoperative pain, shorter length of hospital stay, absence of serious complications, sooner recovery after surgery. Therefore, it has been widely indicated and accepted by surgeons. In Hue, THD has been implemented since April 2013. So far, this procedure has been in more or less common use to treat grade III and IV internal hemorrhoids with or without rectal mucosal prolapse. Method: From April 2013 through September 2013, 79 patients with grade III and IV hemorrhoids with or without rectal mucosal prolapse were treated by means of THD. During the study, postoperative complications, pains, hospital stay and patient’s satisfaction were monitored. Systematic follow-up of patients after surgery were carried out regularly 1 month and 3 months after surgery. Results: With 79 patients with grade III and IV hemorrhoids with or without rectal mucosal prolapse treated with THD, the following results were obtained: (i) THD was performed on 48 (60.8%) male patients, 31 (39.2%) female patients, mean age of 48.7±22.5 years; the youngest 18 and oldest 81 years old; (ii) Average hospital stay was 2.12 ± 1.25 days, the shortest stay 1 day and the longest 5 days. No surgical complications was reported. No serious postoperative complications was reported; (iii) Postoperative pains were found mild in 65 patients (82.2%), moderate in 13 patients (16.5%), and severe in 1 patient (1.3%). No case of postoperative urinary retention was recorded; (iv) Follow-up 1 month after surgery: good results in 71 patients (94.6%) patients, satisfactory results in 4 patients (5.4%) patients; (v) Follow-up 3 months after surgery: good results in 40 (95.2%) patients, satisfactory results in 2 patients (4.8%). Conclusion: Our research shows that surgical treatment of hemorrhoids with THD proves to be a safe procedure, causing less postoperative pains, shorter hospital stay and sooner resumption of work.

Key words: Hemorrhoid disease, transanal hemorrhoidal dearterialisation (THD).
EVALUATION OF LEFT VENTRICULAR TEI&NBSP; INDEX BY DOPPLER ECHOCARDIOGRAPHY IN ELITE ATHLETES
Authors: Nguyen Thi Thuy Hang
Published: March 2020

Background: The literature has recorded ECG changes, cardiac morphology in athletes is known by the term “athlete heart syndrome” with normal heart function. Tei Chuwa devised and published in1995 an index of myocardial performance (the Tei index) that evaluates the LV systolic and diastolic function in combination. To contribute to the assessment of cardiac function athletes in Vietnam, besides conventional Tei index, we further evaluated left ventricular tissue Doppler Tei indexes with the following objectives: identify conventional Doppler Tei index and tissue Doppler Tei indexes in professional athletes, compared with a control group and find the correlation between the Tei index with left ventricular morphology among athletes. Material and Methods: Left ventricular morphology, conventional Doppler Tei index and tissue Doppler Tei indexes in 90 athletes and 90 non-athlete controls were evaluated by Doppler echocardiography. Results: there were no significant differences between the athletes and the control subjects with respect to conventional Doppler Tei index and tissue Doppler Tei indexes (lateral, septal). Morphological parameters were significantly greater in athletes than in controls: left atrial diameter (28.57 ± 4.05 vs 26.94 ± 4.84), LVDd (46.44 ± 4.20 vs 44.01 ± 4.86), IVSd (9.34 ± 1.31 vs 24.94 ± 3.76), LVPWd (8.31 ± 1.54 vs 7.93 ± 1.49), LVMI (85.12 ± 15.86 vs 70.59 ± 14.52), p<0.01, p<0.05. Tei index didn’t have correlation with LADd, left atrial diameter. The left ventricular mass correlated weakly with conventional Doppler Tei index. Conclusion: The athletes had left ventricular structural changes, compared to controls. Heart function was evaluated by Tei index showed normal in athletes.

Keywords: Athlete’s heart, Doppler echocardiography, Tei index.
STUDY OF&NBSP; PLASMA SODIUM DISTURBANCES ON SEVERE TRAUMATIC BRAIN ỊNJURY PATIENTS
Authors: Nguyen Viet Quang
Published: March 2020

Introduction: Traumatic brain injury occurs whenever mechanical force injures the brain. Electrolyte derangement are common after neurologic injury. Many of these patients may receive osmotic diuretics for the treatment of increased intracrinal pressure or develop sodium disturbances, which act to alter fluid balance. Aim of our study is to find the prevalence of electrolyte disturbances in traumatic brain injury patients. Methods: Sodium level of 120 patients in the group of 18-65 years, Glasgow ≤ 8. Results: It was found that 5% of our patients had hypernatremia, 60% of the study subjects suffered from hyponatremia. Conclusion: Sixty five percent of the patients suffered from sodium disturbances of which hyponatremia was the commonest and the most dangerous which needs to be diagnosed and adjusted at the earliest.

Key words: traumatic brain injury, plasma sodium disturbances.
RELATIONSHIP BETWEEN PLASMA TESTOSTERONE LEVELS AND RISK FACTORS IN MALE PATIENTS WITH TYPE 2 DIABETES
Authors: Nguyen Thi Bach Oanh , Nguyen Hai Thuy , Nguyen Cuu Loi
Published: March 2020

Background: Testosterone is vital hormone for men’s health and a keyplayer in glucose homeostasis, lipid metabolism, and cardiovascular pathology. Testosterone deficiency is associated with age, many chronic health conditions and other metabolic disorders. Objectives: Of this study to assess the concentration of plasma testosterone in male patients with type 2 diabetes, and evaluate the relationship between plasma testosterone levels and the assosiated risk factors. Methods: 54 male patients with type 2 diabetes and 31 non diabetes subjects over 45 years old, were assessed plasma tetosterone and lipidemia concentration and risk factore including age, BMI, waist circumference, blood pressure. Results: The concentration of plasma testosterone in type 2 diabetic male patients was lower than that in normal male subjects (4.5± 1.59 vs 5.27± 1.59 ng/ml, p< 0.05). There was significantly difference of plasma tetosterone levels between diabetic patients and controls of < 60 ages and ≥ 60 ages were respectively (4.07± 1.19 vs 5.36± 1.89 ng/ml) and (4.76± 1.76 vs 5.22 ±1.39 ng/ml, p <0.05). There was correlation between plasma testosterone levels with WC (r = - 0.4242, p< 0.01) and BMI (r = -0.37, p<0.01) and no relationship significatively between plasma testosterone concentration with blood pressure and lipidemia in diabetic patients. Conclusions: Concentration of plasma testosterone in type 2 diabetic male patients was lower than that in healthy subjects of similar age, related with age, VB and BMI.

Key words: Testosterone, diabetes, risk factors.
STUDY INTRACRANIAL HAEMORRHAGE IN CHILDREN AT HUE CENTRAL HOSPITAL
Authors: Ton Nu Van Anh , Nguyen Thi Thu Hien
Published: March 2020

Objective: (i) Describe the clinical features, the subclinical intracranial hemorrhage in children. (ii) Identify the risk factors, causes of intracranial hemorrhage in children. Methods: Cross-sectional escriptive study. Results: Study on 34 children with intracranial hemorrhage, study reveals that more boys than girls. The rate of male / female: 2.4/1. The difference was statistically significant in infants under 1 year of age, p<0.05. 76.5% of children hospitalized in the first 24 hours of onset. In children under 1 year of age, symptom onset is the most common seizure 45.8%, poor feeding 25%. In children aged older one year-old, headaches are symptoms first appear 50%, changes in consciousness, seizures, weakness, usually no onset symptoms. Children over 7 days of hospitalization accounted for the highest 50%. The prothrombin rate from 20-50% accounted for the highest percentage of 45.5%. The fontanelle ultrasound in infants, highest percentage of cerebral hemorrhage - grade II 45.5%. With CTscan brain, parenchymal hemorrhage accounted for the highest percentage of 75%. Low- birth weight, asphyxia birth, congenital heart disease highest risk factor caused an intracranial hemorrhage. Common causes bleeding in the intracranial haemorrhage reduce the highest percentage of 64.7%, however, caused by cerebral arteriovenous malformations also relatively high proportion of 17.6%. 4. Conclusions: Children under 1 year- old onset seizures, poor feeding, and older children with a consciousness change. Common causes of incranial hemorrhage by reducing prothombin rate, cerebral arteriovenous malformations.

Key words: Intracranial hemorrhage.
DIFFUSION METHODS FOR CLARITHROMYCIN AND LEVOFLOXACIN SUSCEPTIBILITY TESTING OF HELICOBACTER PYLORI
Authors: Phan Trung Nam , Tran Van Huy , Tran Thi Nhu Hoa , Le Van An
Published: March 2020

Background: The rate of antibiotic resistance in H. pylori is increasing and has become a main cause for failure of treatment. Antibiogram is very important to provide optimal regimens for eradication of H.pylori infected patients. Objective: To determine the resistance prevalence to clarithromycin, levofloxacin of H.pylori strains from patients in Central Vietnam by E-test and disk diffusion isolated, assess the relationship between two diffusion methods. Methods: 56 H.pylori strains were isolated from gastric biopsies of H.pylori infected patients from 7/2012 to 8/2013, of which 13 strains originated from patients in whom eradication of the infection failed after treatment. E-test was used to determine the minimum inhibitory concentrations of clarithromycin (CH) and levofloxacin (LE). Disk diffusion was evaluated as an alternative method to determine susceptibility and compared with the E-test results. Results: In total, the resistant strains (regardless of previous eradication history) to CH, LE were 42,9% and 44,6%, respectively. The ratio of strains with secondary resistance was significantly greater than that of the strains with primary resistance, CH: 84.6% vs. 30.2%, LE: 61.5% vs 39,5% (p < 0.05). The resistance rate to LE in female was significantly higher than in male (p < 0.05). All CH-sensitive strains by E-test had the inhibition diameters of CH was ≥ 24mm and all CH-resistant strains had the inhibition diameters was ≤ 18mm (breakpoint for MIC: 1µg/ml). To LE, the inhibition diameters was ≥ 30mm can determine all LE-sensitive strains and the inhibition diameters was ≤ 26mm can determine all LE-resistant strains by E-test (breakpoint for MIC: 1µg/ml). Conclusions: High resistance rate to CH and LE, suggests that standard CH-based triple therapie may not be useful as the first-line treatment and LE-based triple therapy should not use as an alternative therapy in Central Vietnam. The disk diffusion can use as alternative phenotypic method to determine the susceptbility of H.pylori, which is more practical and inexpensive.

Keywords: Helicobacter pylori, levofloxacin, clarithromycin, E-test antibiotic resistance, disk diffusion.
ULTRASOUND IMAGING OF FATTY LIVER ON GENERAL EXAMINATION PATIENTS AT HUE UNIVERSITY HOSPITAL IN YEAR 2013
Authors: Hoang Minh Loi , Dang Thi Thu Hien
Published: March 2020

Objectives: This study describes the characteristics of hepatic steatosis on ultrasound imaging by grading of Hagen - Assert. Determining the factors related with fatty liver. Methodology: Cross-sectional study. Results: By studying 448 patients went to general examination at Hue University Hospital from 1/5/2013 to 1/9/2013, we have some of comments: 76.1% of patients has hepatic steatosis on ultrasound imaging in the aged of 30-60 years, common in men than women,with male – female ratio:1.23. The majority (96%) hepatic steatosis was complete all lobes, and the remaining 4% patient was focal fatty liver. Grading hepatic steatosis by Hagen-Ansert classification (1995): there were 66.5% grade 1, 30.5% grade 2, and grade 3 of 3.0%. 26 - 32% patients’ hepatic steatosis on ultrasound combinated with increasing of Lipidemia (Cholesterol, Triglycerid and LDL Cholesterol). Conclusion: There were 66.5% patients grading level 1 by Hagen-Ansert classification for hepatic steatosis. Increasing of Lipidemia index represented only 26 – 32% of patients. Our study did not found significant compatible change between the hepatic steatosis on ultrasound imaging and Triglycerid blood concentrations (p > 0.05).

Keywords: Image, ultrasound, hepatic steatosis, fatty liver
Koroner Arter Baypas Greft (KABG) Ameliyatı Olan Hastalarda Aterosklerozun İlerlemesi ile Hematolojik Parametreler Arasındaki İlişki
Authors: YÜCEL Habil , AMANVERMEZ ŞENARSLAN Dilşad
Published: March 2020

Giriş: Yüksek platelet-lenfosit oranı (P/L) ve nötrofil-lenfosit (N/L) oranının sistemik inflamasyon ve kardiyak mortalite ile ilişkisi bilinmektedir. Koroner arter baypas greftleme (KABG) sonrası greft damarlarda aterosklerozun ilerlemesi inflamatuvar süreçlerle ilişkilidir. Bu çalışmada hematolojik parametreler ile KABG sonrası aterosklerozun ilerlemesi arasındaki ilişki araştırıldı.
Yöntemler: Bu retrospektif çalışmada Kasım 2018 ile Kasım 2019 tarihleri arasında merkezimizde KABG ameliyatı öyküsü olan koroner anjiyografi uygulanan hastaların verileri değerlendirilmiştir. CABG uygulanan hastaların demografik özellikler, kan sayımları, N/L oranı ve P/L oranı sonuçları kayıt altına alınarak değerlendirilmiştir.
Bulgular: CABG öyküsü olan 143 hastanın verileri değerlendirildi. Hastalar 3 gruba ayrıldı, greft darlığı olmayan, safen ven (SV) darlığı olan ve sol internal mamarial arter (LİMA) darlığı olanlar. N/L oranı en yüksek LİMA grubunda iken, en düşük greft darlığı olmayan gruptaydı. Tüm gruplar arasında istatiksel olarak anlamlı fark vardı. P/L oranı da LİMA grubunda hem greft darlığı olmayan grupla hem de SV greft grubu ile karşılaştırıldığında daha yüksekti. Ancak SV greft grubu ile greft darlığı olmayan grup karşılaştırıldığında, P/L oranında istatiksel olarak anlamlı bir fark izlenmedi.
Sonuç: Bizim sonuçlarımız CABG olmuş hastalarda yüksek N/L ve P/L oranlarının SV greft darlığı ve LİMA darlığı ile ilişkili olduğunu gösterdi.
A Full Quantum Eigensolver for Quantum Chemistry Simulations
Authors: Wei Shijie , Li Hang , Long GuiLu
Published: March 2020

Quantum simulation of quantum chemistry is one of the most compelling applications of quantum computing. It is of particular importance in areas ranging from materials science, biochemistry, and condensed matter physics. Here, we propose a full quantum eigensolver (FQE) algorithm to calculate the molecular ground energies and electronic structures using quantum gradient descent. Compared to existing classical-quantum hybrid methods such as variational quantum eigensolver (VQE), our method removes the classical optimizer and performs all the calculations on a quantum computer with faster convergence. The gradient descent iteration depth has a favorable complexity that is logarithmically dependent on the system size and inverse of the precision. Moreover, the FQE can be further simplified by exploiting a perturbation theory for the calculations of intermediate matrix elements and obtaining results with a precision that satisfies the requirement of chemistry application. The full quantum eigensolver can be implemented on a near-term quantum computer. With the rapid development of quantum computing hardware, the FQE provides an efficient and powerful tool to solve quantum chemistry problems.
Outpatient pedicle avulsion in DIEP free flap breast reconstruction successfully salvaged: A case report
Authors: Davidson Andrew , Simcock Jeremy
Published: March 2020

Not required
Flying brevet: a technique for mastectomy in female-to-male gender reassignment
Authors: McManus Jeannine Eva
Published: March 2020

Background: Several techniques are described for chest wall contouring in female-to-male (FTM) transgender patients, each with specific applications and limitations. Factors to consider are the aesthetic requirements of the male chest, elimination of anatomical female breast features, operative technique, scar minimisation and success of outcome. We describe the ‘flying brevet’ technique, named for the pattern of excised skin that resembles pilot’s wings. This procedure is tailored to FTM patients but can also be used for large gynaecomastia patients. We present a description of the technique with a retrospective review of outcomes and case series of patients who have undergone this procedure.
Methodology: This is a retrospective review of a single surgeon experience with 113 consecutive patients who have undergone the flying brevet technique. The approach involves a semicircular areolar incision, with superior skin resection and glandular resection. A planned second stage procedure may be performed for larger breasts if required.
Results: Seven per cent incidence of postoperative haematoma, one case of fat necrosis, one case of partial nipple-areolar-complex (NAC) necrosis and one case of full NAC necrosis in the series. There was one postoperative infection and six per cent incidence of hypertrophic scarring.
Conclusions: The flying brevet provides a consistent method of mastectomy for FTM chest wall reconstruction. It permits large glandular and skin resection in ptotic breasts with preservation of NAC circulation. The flying brevet is an additional technique that can be added to the current options for mastectomy in FTM chest wall reconstruction.
A New Approach to Optimizing Network Bandwith and Transfer Rate on Mission Critical Computer Networks: “Network Quality and Resource Manager”
Authors: ERZURUMLU Kerem
Published: March 2020

In this paper, a new approach and solution of the one of the biggest problem on mission critical networks, network and bandwidth optimization will be described.

The developed “Network Quality and Resource Manager” ensures the quality of network bandwidth and transfer rate on isolated mission critical networks like high resolution IP based security camera surveillance systems.

The “Network Quality and Resource Manager” uses “Quality of Service”, and “Address Resolution Protocol Table” via Simple Network Management Protocol (a.k.a. SNMP) over manage-able at-least 2nd layer network devices. Hence NQRM uses SNMP, it is vendor independent and can work with any network architecture.