bluuebunny/crossref_metadata_2025 huggingface dataset:
Michael Acceptors as a Tool for Anticancer Drug Design
Authors: Ahn Byung-Zun , Sok Dai-Eun
Published: September 2022

Interaction of antitumor drugs with cellular targets involves various types of chemical binding, of which covalent binding is one of important strategies in designing effective anticancer molecules. The anticancer compounds employing covalent binding, structurally diverse, belong to many chemical classes, including quinones, mustards, nitrosourea, alkylsulfonate, pyrrolo[l,4]benzodiazepines, and others. Most of these compounds contain, or acquire by cellular metabolism, electrophilic centers, and some are Michael acceptors in a broader sense.
Recent evidences suggest that antineoplastic alkylating compounds bind directly to various cellular nucleophiles, thus lacking in a selectivity. Meanwhile, Michael acceptors can be structurally modified, so that they can react selectively with target nucleophiles or they can be converted into a selective Michael acceptors during metabolism. Moreover, we often meet these Michael acceptors in biochemical process of cellular respiration or in metabolisms of some drugs or xenobiotics.
A group of representative natural cytotoxic compounds containing Michael acceptor are naphthoquinones such as menadione and shikonin analogues, cytotoxic quassinoids, sesquiterpenoid benzoquinones, and others. Mitomycin, meanwhile, is transformed by reductive activation into a conjugated dienone as a Michael acceptor.
In this review, chemistry, cytotoxicity and antitumor action of anticancer agents containing Michael acceptors will be discussed in the respect of structure-activity relationship. More in-depth review will be given of the naphthazarin analogues. Also, cytotoxic terpenes such as ar-turmerone analogues, quassinoids, and others will be reviewed.
Post-COVID-19 Pandemic Impact Assessment of Bioinformatics and Women Bioinformaticians: A Realm of Possibilities or Gloom-Ridden
Authors: Singh Sakshi , Kaur Arvinpreet , Kakkar Purnima , Dhar Sujata , Madduru Dhatri , Yasin Jeshima Khan , Banerjee Aparna , Suravajhala Renuka
Published: September 2022

COVID-19 has greatly influenced the worldwide scientific community to shift its focus towards computational and multidisciplinary approaches to meet the needs around the world. In contrast, a downfall in women computational biologists was significant, attributed to stress in balancing professional and personal household responsibilities due to the preexisting gender gap, especially in India. Additionally, surging cases, deadlines of incomplete projects, and the dilemma about prospects adversely influence productivity, which can be addressed by support and understanding from the family, at the office, and between the mentor and the protégé. A potential focus on life science research, especially computational biology, is anticipated in Post-COVID times.
Innovation characteristics and technology adoption on Probio_FM in the implementation of an integrated farming system in Bangka Tengah
Authors: Astuti Rufti Puji , Bahtera Novyandra Ilham , Agustina Fournita
Published: September 2022

The strategy to disseminate innovative technology is vital. It expects the technology to be effective and can be adopted. The assessment of the perception of farmers towards the characteristics of innovative technology is needed to identify the potential implementation of sustainability. The study aims to understand the characteristics of technology innovation of Probio_FM in the food processing of palm oil and to examine the impact of innovation characteristics on the adoption of innovation. The survey was employed as the research method. Structural equation modeling with smart partial least squares was used to analyze the data. The study discovered that the innovation characteristics and adoption of Probio_FM technology were relative advantages, compatibility, complexity, liability, and observability. The innovation characteristics had a significant impact on the adoption process. Technology innovation was accepted by society. The variable of relative advantage, trialability, and compatibility was the most important innovation characteristic of livestock farmers in the process of adoption of Probio_FM technology in food processing of palm oil.
The role of the digitized milk collection point in increasing milk quality and income of smallholder dairy farmers in Pangalengan-Bandung
Authors: Erwidodo Erwidodo , Purwantini Tri Bastuti , Anugrah Iwan Setiajie , Ariningsih Ening , Saliem Handewi Purwati , Suryani Erma
Published: September 2022

The low quality of fresh milk has become one of the main constraints smallholder dairy farmers face in almost all developing countries, including Indonesia. The low quality of fresh milk has resulted in lower prices received by farmers. It can even result in the rejection of milk by milk processors, which is detrimental to smallholder farmers. This paper aims to analyze the impact of automated and digitized milk collection points (AD-MCPs) on the quality of fresh milk, the price of milk, and smallholder dairy farmers' income in Pangalengan, Bandung, West Java. The data and information of 300 households are part of the baseline survey of 600 smallholder dairy farmers in four districts of West Java between July and September 2017. The results show that AD-MCP facilities have successfully encouraged smallholder dairy farmers to adopt and implement improved management practices to increase dairy cows' productivity and fresh milk quality, resulting in increased prices and farm income.Â Â Â Therefore, the government needs to endorse, facilitate, and accelerate the development of AD-MCPs to increase domestic fresh milk production, quality of fresh milk, and dairy farmers' income. AD-MCP development is implemented through a partnership between dairy farmers, cooperatives, and milk processors.
Electron Diffraction Study of Phase Formation in Nano Layers of Cu-=SUB=-2-=/SUB=-Te-In-=SUB=-2-=/SUB=-Te-=SUB=-3-=/SUB=-, Cu-In-Te Systems and Short-Range Atomic Order in Amorphous CuIn-=SUB=-5-=/SUB=-Te-=SUB=-8-=/SUB=- Films
Authors: Dashdamirova G. E.  , Asgerov E. B.  , Ismailov D. I.
Published: September 2022

It is shown that with the simultaneous and sequential deposition of films of the Cu2Te-In2Te3 system, as well as copper, indium, and tellurium of the highest purity used as starting materials, ~99.999%, taken in the ratio Cu : In : Te = 1 : 5 : 8, regardless of the deposition order ternary compounds of the compositions CuInTe2, CuIn3Te5, and CuIn5Te8 in the crystalline state are distinguished. During vacuum condensation of films on single-crystal substrates NaCl, KCl and amorphous celluloid cooled by liquid nitrogen to 203 K, the resulting films obtained both by co-evaporation of binary compounds of the Cu2Te-In2Te3 system and by the synthesis of thin layers applied by Cu, In, Te are amorphous. For the first time in nanosized amorphous films of the composition CuIn5Te8, crystallizing in the tetragonal system with the periods of unit cells a=6.162 Angstrem, c=12.291 Angstrem, obtained both under normal conditions and under the influence of an external electric field with a strength of 500 V · cm-1, the structure of the short-range atomic order is established --- the number of nearest neighbors --- coordination numbers and radius of coordination spheres. It was revealed that in amorphous CuIn5Te8 films obtained under the influence of an external electric field, in which the matrices consist of tetrahedral and octahedral environments of atoms, in opposite to films that are formed outside the field, the number of nearest neighbors remains unchanged, the radius of coordination spheres and interatomic distances are somewhat are shortened. Keywords: phase formation, elektronogram, radial distribution function of atoms (RDFA), coherent electron scattering.
Photoluminescence spectroscopy of HgCdTe quantum well heterostructures in the 15-30 μm wavelength range
Authors: Rumyantsev V. V.  , Razova A. A.  , Kozlov D. V.  , Fadeev M. A.  , Maremyanin K. V.  , Utochkin V. V.  , Mikhailov N. N.  , Dvoretsky S. A.  , Gavrilenko V. I.  , Morozov S. V.
Published: September 2022

In recent years, narrow gap heterostructures with Hg1-xCdxTe/CdyHg1-yTe quantum wells have been actively studied both in connection with the topic of topological insulators and from the point of view of their application in optoelectronics in the terahertz domain. In this work, we study the photoconductivity and photoluminescence spectra of structure with a band gap of 40 meV. In addition to interband transitions, the features of the spectra associated with the resonance states of acceptors have been identified. The possibilities of using the structures under study to develop interband emitters at a wavelength of ~30 μm, which is inaccessible to existing quantum-cascade lasers, are discussed. Keywords: narrow-gap semiconductors, HgCdTe, resonance states, acceptors, photoluminescence.
Photodetectors based on GaInAsSb/GaAlAsSb heterostructures for the practical tasks of precision diode laser spectroscopy
Authors: Kunitsyna E. V.  , Andreev I. A.  , Konovalov G. G.  , Pivovarova A. A.  , Il`inskaya N. D.  , Yakovlev Yu. P.  , Ponurovskii Ya. Ya.  , Nadezhdinskii A. I.  , Kuz'michev A. S.  , Stavrovskii D. B.  , Spiridonov M. V.
Published: September 2022

The paper considers the uncooled photodetectors based on GaInAsSb/GaAlAsSb heterostructures, which can be applied in precision diode laser spectroscopy. The spectral sensitivity range of photodetectors with a photosensitive area diameter of 1.0 mm and 2.0 mm is 1.0-2.4 μm. The current monochromatic sensitivity at the wavelength of 2.1 μm has a value of 1.0 A/W without bias. The capacity reaches 375 pF with a photosensitive area diameter of 1.0 mm and 800-5000 pF with 2 mm. The modern gas analyzers based on diode lasers and developed photodetectors for medical screening diagnostics by analyzing the gas compositions of exhaled air, for control of impurity gases in the process of rectification of inorganic hydrides, control of methane leaks in gas pipelines, as well as for registration of exhaust gases of a moving car are presented. Keywords: photodetector, heterostructure, diode laser spectroscopy, gas analyzer.
Patient-Reported Outcome Dashboards Within the Electronic Health Record to Support Shared Decision-making: Protocol for Co-design and Clinical Evaluation With Patients With Advanced Cancer and Chronic Kidney Disease
Authors: Perry Laura M , Morken Victoria , Peipert John D , Yanez Betina , Garcia Sofia F , Barnard Cynthia , Hirschhorn Lisa R , Linder Jeffrey A , Jordan Neil , Ackermann Ronald T , Harris Alexandra , Kircher Sheetal , Mohindra Nisha , Aggarwal Vikram , Frazier Rebecca , Coughlin Ava , Bedjeti Katy , Weitzel Melissa , Nelson Eugene C , Elwyn Glyn , Van Citters Aricca D , O'Connor Mary , Cella David
Published: September 2022

Background

Patient-reported outcomes—symptoms, treatment side effects, and health-related quality of life—are important to consider in chronic illness care. The increasing availability of health IT to collect patient-reported outcomes and integrate results within the electronic health record provides an unprecedented opportunity to support patients’ symptom monitoring, shared decision-making, and effective use of the health care system.

Objective

The objectives of this study are to co-design a dashboard that displays patient-reported outcomes along with other clinical data (eg, laboratory tests, medications, and appointments) within an electronic health record and conduct a longitudinal demonstration trial to evaluate whether the dashboard is associated with improved shared decision-making and disease management outcomes.

Methods

Co-design teams comprising study investigators, patients with advanced cancer or chronic kidney disease, their care partners, and their clinicians will collaborate to develop the dashboard. Investigators will work with clinic staff to implement the co-designed dashboard for clinical testing during a demonstration trial. The primary outcome of the demonstration trial is whether the quality of shared decision-making increases from baseline to the 3-month follow-up. Secondary outcomes include longitudinal changes in satisfaction with care, self-efficacy in managing treatments and symptoms, health-related quality of life, and use of costly and potentially avoidable health care services. Implementation outcomes (ie, fidelity, appropriateness, acceptability, feasibility, reach, adoption, and sustainability) during the co-design process and demonstration trial will also be collected and summarized.

Results

The dashboard co-design process was completed in May 2020, and data collection for the demonstration trial is anticipated to be completed by the end of July 2022. The results will be disseminated in at least one manuscript per study objective.

Conclusions

This protocol combines stakeholder engagement, health care coproduction frameworks, and health IT to develop a clinically feasible model of person-centered care delivery. The results will inform our current understanding of how best to integrate patient-reported outcome measures into clinical workflows to improve outcomes and reduce the burden of chronic disease on patients and health care systems.

International Registered Report Identifier (IRRID)

DERR1-10.2196/38461
Detecting Medication-Taking Gestures Using Machine Learning and Accelerometer Data Collected via Smartwatch Technology: Instrument Validation Study (Preprint)
Authors: Odhiambo Chrisogonas Odero , Ablonczy Lukacs , Wright Pamela J , Corbett Cynthia F , Reichardt Sydney , Valafar Homayoun
Published: September 2022

BACKGROUND

Medication adherence is a global public health challenge, as only approximately 50% of people adhere to their medication regimens. Medication reminders have shown promising results in terms of promoting medication adherence. However, practical mechanisms to determine whether a medication has been taken or not, once people are reminded, remain elusive. Emerging smartwatch technology may more objectively, unobtrusively, and automatically detect medication taking than currently available methods.

OBJECTIVE

This study aimed to examine the feasibility of detecting natural medication-taking gestures using smartwatches.

METHODS

A convenience sample (N=28) was recruited using the snowball sampling method. During data collection, each participant recorded at least 5 protocol-guided (scripted) medication-taking events and at least 10 natural instances of medication-taking events per day for 5 days. Using a smartwatch, the accelerometer data were recorded for each session at a sampling rate of 25 Hz. The raw recordings were scrutinized by a team member to validate the accuracy of the self-reports. The validated data were used to train an artificial neural network (ANN) to detect a medication-taking event. The training and testing data included previously recorded accelerometer data from smoking, eating, and jogging activities in addition to the medication-taking data recorded in this study. The accuracy of the model to identify medication taking was evaluated by comparing the ANN’s output with the actual output.

RESULTS

Most (n=20, 71%) of the 28 study participants were college students and aged 20 to 56 years. Most individuals were Asian (n=12, 43%) or White (n=12, 43%), single (n=24, 86%), and right-hand dominant (n=23, 82%). In total, 2800 medication-taking gestures (n=1400, 50% natural plus n=1400, 50% scripted gestures) were used to train the network. During the testing session, 560 natural medication-taking events that were not previously presented to the ANN were used to assess the network. The accuracy, precision, and recall were calculated to confirm the performance of the network. The trained ANN exhibited an average true-positive and true-negative performance of 96.5% and 94.5%, respectively. The network exhibited <5% error in the incorrect classification of medication-taking gestures.

CONCLUSIONS

Smartwatch technology may provide an accurate, nonintrusive means of monitoring complex human behaviors such as natural medication-taking gestures. Future research is warranted to evaluate the efficacy of using modern sensing devices and machine learning algorithms to monitor medication-taking behavior and improve medication adherence.
A NOVEL RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR THE QUANTIFICATION OF A POTENTIAL ANTI-DIABETIC DRUG METFORMIN HYDROCHLORIDE IN TABLET DOSAGE FORM
Authors: HIREMATH JAYASHREE A. , KUMAR HARISH
Published: September 2022

Objective: This study was conducted to develop a simple, economical, linear, rapid method for the assay studies of Metformin HCl by RP-HPLC method and to carry out the method validation.

Methods: A simple, robust and accurate method to carryout assay of Metformin hydrochloride tablet(500 mg) by RP-HPLC method in which the stationary phase used is Shimadzu shim-pack GIST C18 column with specification (5μm×4.6×250 mm). This method involves isocratic elution of mobile phase containing 70% buffer and 30% acetonitrile. The buffer used for analysis is Tetra-Butyl Ammonium Hydroxide (0.002%), the flow rate was maintained at 0.5 ml/min. detection was done at 232 nm. Principal peak for Metformin was observed at 3.5 min and the runtime for each injection was set to 10 min. The standard solutions of Metformin were prepared using purified water (milli-Q water) and scanned from 190 nm to 400 nm. Sharp peaks were observed in the range of 232 nm and thus, wavelength of 232 nm was selected and used throughout the validation process.

Results: Linearity graph generated was found acceptable and accurate and the graph was generated in the range of 50% to 150% concentration. The regression coefficient was found to be 0.999(acceptable range). Validation was carried out according to ICH guidelines and found to be acceptable.

Conclusion: This developed method was found to be simple, robust, economical, accurate, linear and can be used in the assay of Metformin tablet using RP-HPLC.
Detecting Anemia Based on Palm Images using Convolutional Neural Network
Authors: Rizal Ahmad Saiful , Hadi Alfian Futuhul , Sudarko Sudarko , Supangat Supangat
Published: September 2022

Hemoglobin is a protein in the blood that conveys oxygen from the lungs to the body's tissues. Hemoglobin levels under the normal limit cause anemia. Hemoglobin estimation is generally utilizing a needle to take the patient’s blood as a sample and afterward testing it at the chemicals laboratory. This technique has a shortcoming, specifically, it is less proficient because it requires a few hours. Likewise, it needs to hurt the patient's skin with a hypodermic needle. In this study, we will discuss the Convolutional Neural Network (CNN) in classifying hemoglobin levels based on palm images. Hemoglobin levels are partitioned into two classes, to be anemia and non-anemia. The image size utilized is 500×375 pixels with the number of Red, Green, and Blue (RGB) channels. The data utilized in this study were images of the patient's palm. The first important phase in this research was data retrieval, which went on with preprocessing data, then the data is clustered into two clusters using a random state, then at that point, each cluster will be classified using the CNN algorithm. The best results are obtained by the value of accuracy reached 96.43% with a precision score of 93.75% achieved, recall of 100%, and specificity of 92.31% for cluster 1 in random state 1, and the similar random state for cluster 2 is obtained the value of accuracy reached 96.43% with a precision score of 93.33%, recall of 100%, and specificity of 92.86% were achieved this way.
Antiulcer, analgesic and hepatoprotective activities of hydroalcoholic root extract of Jurinea Dolomiaea Boiss against carbon tetrachloride induced hepatopathy in rats
Authors: Bhat Mushtaq Ahmad , Khan Fairooz Ahmad , Saifuddin Quazi , H.C.Kataria Dr.
Published: September 2022

The plant Jurinea Dolomiaea Boiss belonging to family Astraceae traditionally used in Ayurvedic system as antidiabetic, antioxidant, antibacterial, antitumor and also used in liver disorders. In this study, water and hydroalcoholic root extracts of Jurinea dolomiaea boiss was studied for antiulcer, analgesic and hepatoprotective properties against carbon tetrachloride induced hepatotoxicity in albino wistar rats. Hydroalcoholic extract of Jurinea dolomiaea root (100mg/kg and 200mg/kg p.o) were administered to the experimental rats for seven days. The hepatoprotective activity of hydroalcoholic extract of Jurinea dolomiaea roots were evaluated by estimation of SGOT, SGPT, ALP and total bilirubin. Histopathology of the liver was also studied. In the hydroalcoholic extract of Jurinea dolomiaea roots treated animals, the toxic effect of carbon tetrachloride was controlled significantly by restoration of the increased levels of SGOT, SGPT, ALP and total bilirubin as compare to the toxicant control. The hydroalcoholic extract of roots of Jurinea dolomiaea showed significant hepatoprotective activity.
GSM-АНТЕННЫ КОМПАНИИ RUICHI
Authors: Москалев В.
Published: September 2022

GSM – наиболее востребованный в мире стандарт сотовой связи, на долю которого приходится около 82% мирового рынка мобильной телефонии. В статье рассмотрены особенности, характеристики и области применения GSM-антенн от компании Ruichi.
The Association of High COVID-19 Cases and Mortality with Anomalous High Surface Ozone Concentration in Moscow City in Summer 2021
Authors: Stepanov E. V. , Andreev V. V. , Chuprov D. V. , Ivashkin V. T.
Published: September 2022

Aim: to compare statistical data on the frequency of COVID-19 and deaths from it with the ozone content in the surface atmosphere of Moscow in the summer of 2021.

Materials and methods. We used data on the frequency of daily COVID-19 cases and mortality from COVID-19 in Moscow in 2020–2021 published by Rospotrebnadzor. Data on the ozone content in the surface layer of the atmosphere were obtained by an automatic monitoring station using a chemiluminescent analyzer.

Results. The waves of high frequency of COVID-19 cases and mortality from COVID-19 in Moscow in the summer of 2021 were compared with abnormally high concentrations of ozone in the surface atmosphere of the megalopolis. Variations of these parameters were found to be markedly correlated. The coefficients of correlation of the COVID-19 cases and mortality with the concentration of ground-level ozone were 0,59 (p < 0.01) and 0.60 (p < 0.01), respectively.

Conclusion. The observed noticeable relationship may be due to the combined pathological effect of high concentrations of ozone and the SARS-CoV-2 on the respiratory and circulatory organs, which can lead to both easier transmission of infection and a more severe course of the disease with increased mortality.
Prevalence of Small Intestinal Bacterial Overgrowth Syndrome in Patients with Irritable Bowel Syndrome who Have Suffered COVID-19
Authors: Nalyotov A. V. , Guz N. P.
Published: September 2022

Aim. To study the prevalence of the small intestinal bacterial overgrowth syndrome in patients with irritable bowel syndrome with diarrhea who have had COVID-19 infection.

Materials and methods. 60 patients with irritable bowel syndrome with diarrhea were examined. In 30 patients, irritable bowel syndrome was diagnosed after COVID-19 infection (main group). The comparison group consisted of 30 patients with classical stress-induced irritable bowel syndrome. The small intestinal bacterial overgrowth syndrome was diagnosed using a hydrogen breath test with lactulose loading in all patients.

Results. In main group the small intestinal bacterial overgrowth syndrome was diagnosed in 93.3 % patients, which was statistically significantly higher (p < 0.01) relative to the comparison group — 60.0 % patients

Conclusion. Irritable bowel syndrome in patients who have undergone COVID-19 occurs against the background of the small intestinal bacterial overgrowth syndrome development.
Modern Approaches to Vaccination of Patients with Chronic Liver Diseases and Inflammatory Bowel Diseases against a Novel Coronavirus Infection
Authors: Sheptulin A. A. , Ivashkin V. T.
Published: September 2022

Aim. To analyze the literature data on the peculiarities of vaccination of patients with chronic liver diseases (CLD) and inflammatory bowel diseases (IBD) against COVID-19 infection.

Key findings. It has been shown that many patients with CLD (cirrhosis of the liver, non-alcoholic fatty liver disease) have a higher risk of severe course of a novel coronavirus infection, which necessitates their vaccination. IBD patients are also subject to vaccination, although the immunomodulatory drugs which they take may reduce its effectiveness. In addition, the correct timing of the vaccine administration is of great importance. Vaccination of patients with CLD and IBD is safe, and the frequency of side effects during its implementation does not differ from that in the general population.

Conclusion. Analysis of literature data shows that patients with CLD and IBD are subject to vaccination against COVID-19 infection, which is effective and safe.
Auricular mucormycosis complicated by parotid abscess and facial paralysis: A very rare case report
Authors: Hammami Bouthaina , Achour Imen , Walha Omar , Yousfi Ghada , Mnejja Malek , Charfeddine Ilhem
Published: September 2022

Mucormycosis is a serious and relatively rare invasive fungal infection.
The rhino-orbito-cerebral localization is the most frequent.
Mucormycosis of external ear with facial palsy is extremely rare. We
describe a case of mucormycosis of the external ear complicated by
parotid abscess and facial palsy in a diabetic patient.
Effects of different pitfall trap designs on capture efficiency of scorpions (Arachnida, Scorpiones), towards an optimized trap
Authors: Bakhshi Yaser , Sadeghi Reza , Daneshnia Ali , Khoobdel Mehdi
Published: September 2022

Pitfall trapping is one of the widely used methods in ecological studies
to assess epigean arthropods’ diversity and density. Our work is the
first study to evaluate the capture efficiency of different pitfall
traps for collecting scorpions. We examined the impact of trap diameter,
trap cover, and use of funnels, and designed eight different trap types
by combining these factors. A total of 64 traps were tested in an arid
plain in Khuzestan Province, southwest Iran, during winter and spring
over a 24-day period, and a total of 772 scorpions were trapped. The
results indicate that pitfall traps are most productive for capturing
burrowing scorpions. In addition, most scorpions were captured with
covered traps, which can be explained by the cryptic lifestyle of
scorpions, which tend to use spaces under rocks and other objects for
shelter or to search for their prey. It is also noted that larger traps
catch more scorpions, and the use of funnels does not significantly
affect the number of scorpions caught. However, using funnels is
recommended because it can reduce the number of unwanted bycatch
samples. Based on our results, an optimized trap design for collecting
scorpions is proposed, namely a funnel trap with an opening diameter of
ca. 15 cm equipped with a plastic cover.
A non-systemic phosphodiesterase-5 inhibitor suppresses colon proliferation in mice
Authors: Lee Avelina , Lebedyeva Iryna , Zhi Wenbo , Senthil Vani , Cheema Herjot , Brands MIchael , Bush Weston , Lambert Nevin , Snipes Madeline , Browning Darren
Published: September 2022

Background and Purpose: Phosphodiesterase-5 inhibitors (PDE5i) are under
investigation for repurposing as an intervention for colon cancer
prevention. A drawback to conventional PDE5i are side-effects and
drug-drug interactions that would be poorly tolerated when taken on a
chronic basis for prevention. Experimental Approach: We designed an
analog of the prototypical PDE5i sildenafil by replacing the methyl
group on the piperazine ring with malonic acid to reduce lipophilicity
and measured its entry into the circulation and effects on colon
epithelium. Key Results: This modification did not affect pharmacology
as malonyl-sildenafil had a similar IC50 to sildenafil (6.5 nM vs 7.5 nM
respectively) but exhibited almost 100-fold reduced cell entry compared
to sildenafil. Using an LC-MS/MS approach, doses of malonyl-sildenafil
up to 36 mg/kg were barely detectable in mouse plasma after oral
administration but was detected at high levels in the feces. This
contrasted with sildenafil that was detected in the plasma but not in
the feces. No bioactive metabolites of malonyl-sildenafil were detected
in the circulation by measuring interactions with isosorbide
mononitrate. Treatment of mice with malonyl-sildenafil in the drinking
water for 8 days was well-tolerated and resulted in a suppression of
proliferation in the colon epithelium that is consistent with results
published previously for mice treated with PDE5i. Conclusion and
Implications: A carboxylic acid-containing analog of sildenafil
prohibits systemic delivery of the compound but maintains sufficient
penetration into the colon epithelium to suppress proliferation. This
highlights a novel approach to generate a first in class drug for colon
cancer chemoprevention.
Paper formats of graphene and CNT: Multiscale simulations
Authors:   , Chandra Yatish
Published: September 2022

Carbon-based nanostructures are receiving increasing attention over the past two decades due to their outstanding multi-functional features. However, the macro-scale structural applications of these nanostructures have not yet come to full fruition due to the involvement of complex multi-scale computations and manu-facturing. Recently, the research community has started investigating macroscopic paper formats of graphene and carbon nanotubes(PFGCN). The PFGCNs include graphene paper and buckypaper. The buckypaper is a membrane composed of a network of bundles of single-wall carbon nanotubes (SWCNT), multi-wall carbon nanotubes (MWCNT), or a mixture of both. The graphene paper is also a macro-scopic membrane composed of a network of graphene nanosheets. The current thesis thrives on advancing the science and technology of PFGCN by focusing on three goals. The ﬁrst goal is to perform a thorough statistical analysis of the mechanical properties of PFGCN. The second goal is to conduct a computa-tional bridging of diﬀerent length scales involving six levels in the range of nano to macro-scale behaviour concerning PFGCN composites. The third goal is to demonstrate the compatibility of the PFGCN with an engineering product. The statistical analysis has reviewed 600 research papers to examine the mechanical properties of PFGCN and its associated composite materials. The data spanning 20 years of research has been quantitatively and qualitatively presented here, with the aid of statistical tabulations and Ashby plots. Mainly, the inﬂuence of geome-try and chemistry of PFGCN on mechanical properties has been investigated. To address the second goal, the multi-length scale simulations consider sequential car-bon derivatives at six levels, involving graphene, SWCNT, MWCNT, CNT bundle, buckypaper and buckypaper composite automotive components. The multi-scale simulations are based on a coupled atomistic-continuum modelling approach for multilevel simulations. At the macro-scale, an industry-relevant multi-material composite automotive component has been investigated, wherein the buckypa-per is proposed to be embedded involving sheet moulding compound (SMC) and carbon prepreg. The simulations have led to the determination of mechanical properties at each carbon-based material level and their mutual dependence. To address the third goal, a detailed numerical analysis as per the industry regu-lations has been carried out on the PFGCN embedded automotive component. The numerical results demonstrate that a buckypaper composite can enhance the durability and vibrational performance with respect to conventional monolithic metallic designs while reducing the component weight. Such outcomes lead to the realization that carbon-based nanostructural derivative in the form of buckypa-per can signiﬁcantly improve the mechanical properties of advanced lightweight structural components as reinforcements for the next generation of aerospace and automotive structures.
Pelatihan dan Pembuatan Video Pembelajaran pada TK AL-Islam Tambak Bayan Yogyakarta
Authors: Hetty Primasari Clara , Sitepu Roberto Reno , Virgi Yandi Saputra Lutgarda , Suryo Prayogo Thomas Edwin , Hansel Emmanuel , Odie Kristiawan Bernardinus , Wahyu Sedana I Gede
Published: September 2022

Pengabdian ini di latar belakangi oleh kesulitan dalam mengajar di era pandemi yang membuat para guru harus mengadaptasi seluruh kegiatan belajar mengajar menjadi daring. Adaptasi pembelajaran secara daring menjadi tantangan tersendiri khususnya bagi guru TK AL-Islam Tambak Bayan.  Siswa TK masih belum bisa memahami kompleksitas yang ada pada pembelajaran secara daring. Oleh karena itu, banyak metode yang kurang cocok dan ketidakmampuan guru dalam menerapkan teknologi informasi dalam kegiatan belajar mengajar. Hal ini menyebabkan kegiatan belajar mengajar menjadi seadanya saja sehingga tidak dapat berjalan dengan baik. Tujuan pengabdian ini yakni untuk membantu serta melatih guru TK AL-Islam Tambak Bayan dalam menyajikan materi pembelajaran melalui video animasi yang menarik sehingga siswa TK memiliki kemauan untuk belajar. Metode yang digunakan yaitu pelatihan dan pembuatan video pembelajaran dengan menggunakan Animaker, untuk kemudian video tersebut dapat diakses secara daring. Hasil yang didapatkan dari pengabdian ini adalah para guru TK AL-Islam Tambak Bayan mampu memahami fitur dan cara menggunakan Animaker serta dapat membuat video pembelajaran animasi yang menarik dan mudah dipahami bagi murid TK.
Celebrando uma identidade: os usos do passado para enaltecimento da paraibanidade na música Paraíba Joia Rara
Authors: Silva Glauber Paiva da , Oliveira Ana Lúcia Do Nascimento
Published: September 2022

A música ao longo da história se incorporou em nosso dia a dia, estando presente nos mais variados momentos de nossas vidas. Assim, ela nos remete a uma variedade de sentimentos como alegria, tristeza e saudade. Desde o início do século XX, diversas músicas foram compostas se utilizando da premissa sentimental de pertencimento. Desse modo, muitas delas foram criadas em meio a indústria cultural com o intuito de despertar o enaltecimento de uma identidade, seja ela nacional, regional ou mesmo local. É por meio dessa construção que iremos nos debruçar sobre uma dessas músicas que se tornou patrimônio cultural imaterial do estado da Paraíba. Paraíba Joia Rara se utiliza do passado para engrandecer e celebrar a história e cultura paraibana. Portanto, nos debruçaremos sobre esse objeto para tentarmos perceber as suas relações com os patrimônios, a identidade cultural, a história e o povo paraibano. Para isso, nos utilizaremos das reflexões de Castagna (2016) e Soares (2017), que nos ajudarão a entender os diálogos entre patrimônios musicais brasileiros e ensino de história. Acreditamos que essa pesquisa é importante para nos fazer compreender melhor essas construções de enaltecimento de uma identidade, como também para contribuir com o campo e salvaguardar os patrimônios musicais brasileiros.
Memórias das Bandas de Goiás: tradições, imaginários e identidades nas entrevistas nas cidades históricas de Goiás do acervo do BandaLab
Authors: Botelho Marcos
Published: September 2022

O presente artigo analisa o acervo “Memórias das Bandas de Goiás” do BandaLab-UFG, que possui entrevistas/depoimentos obtidos em 2 projetos de pesquisas desde 2016, que foram gravadas em 4 cidades históricas de Goiás: Cidade de Goiás, Pirenópolis, Corumbá de Goiás e Jaraguá. O foco tem sido registrar a memória dos integrantes das bandas, assim como de pessoas locais que são admiradores e seguidoras delas. Assim, utilizando o conceito de reminiscência pessoal, buscamos nas entrelinhas e coincidências dos discursos as memórias, imaginários e sentimentos de identidades dos entrevistados em relação as bandas e as cidades as quais elas pertencem. Notamos grande sentimento de identidade entre os membros das bandas, além do sentimento de pertencimento por parte de seus admiradores. Demostram que consideram como tradição as festas tradicionais locais e as músicas que as bandas tocam nessas atividades. As bandas e as tradições locais se confundem, sendo que a banda possui papel essencial nas festas e atividades culturais em cada cidade, muitas vezes confundindo-se.
O arquivo musical da Orquestra Lira Sanjoanense no tempo da Companhia de Muzica
Authors: Fonseca Modesto Flávio Chagas
Published: September 2022

O arquivo de documentos musicais da Orquestra Lira Sanjoanense é constituído de grande quantidade de fontes que transmitem obras musicais para as mais diversas demandas de ritos na sociedade local, sejam religiosos ou de entretenimento. Ter em foco obras acumuladas no exercício das funções propostas pelo grupo musical denominado de Companhia de Múzica é oportunidade para uma imerssão na dinâmica social de São João del-Rei na primeira metade do século XIX, vislumbrada pela ótica da prática musical. Esta ação permite verificar a organicidade dos documentos produzidos por aqueles músicos com os propósitos da instituição musical por eles delineada.
Analisis Kadar Rada'ah yang Mengharamkan Pernikahan Dalam Perspektif Hukum Islam
Authors: Adminfamilia Ali Zainal Abidin
Published: September 2022

Salah satu makanan terbaik yang dianugrahkan oleh Allah SWT adalah asi buat seorang bayi melalui perantara seorang ibu agar dapat terjamin kelangsungan hidupnya dikemudian hari, dan perempuan yang menyusukan tersebut menjadi ibunya dan diharamkan pernikahan denganya dan segenap keturunannya, itu konsekuensi atau efek hukum yang diatur oleh syariat. Perdebatan para ulama mazhab jumhur dan ibn hazm dan mazhab syafii dan mazhab imam ahmad bin hanbal, pasalnya apakah hubungan susuan terjadi seketika ketika bayi minum susu wanita? Jawabannya tidak karena harus melihat kadar susuan yang diminum bayi tersebut dan berapakah  umur bayi yang menyusui? beberapa dalil dari al-Quran dan Hadis yang masih menjadi perdebatan di kalangan ulama dalam membahas masalah ini.
Giorgio Colli
Authors: Boqué Marc
Published: September 2022

Giorgio Colli ha sido uno de los autores contemporáneos que más han contribuido a revisar la figura de Apolo, entendiéndola como una potencia expresiva vinculada tanto a los designios asociados a su arco como a los coligados a su lira. Una ambigüedad expresiva que examinamos en este artículo y que, veremos, articulará simbólicamente la reforma histórica que Colli detectará en el paso de la sabiduría oral a la filosofía griega escrita, pero también la que se producirá entre una ontología-política arcaica de ámbito contingente y una politeia, ya clásica, ligada a la necesidad, y de carácter retórico, estetizado y comunicativo.
Eszter Hargittai (Ed.). Research exposed. How empirical social science gets done in the digital age
Authors: Mützel Sophie
Published: September 2022

Research Exposed. How Empirical Social Science Gets Done in the Digital Age is an edited volume with 12 chapters that individually and as a collection have the ability to draw the reader in – like the stories of a cook in a kitchen would do, who is narrating how they came to concoct a particular recipe, how approaches failed, what worked, how they found out, and which turn led to the final recipe. Analogously, this edited volume by Eszter Hargittai allows us to look behind the scenes of how empirical social science is being done. Adding to previous edited collections Research Confidential (Hargittai, 2009) and Digital Research Confidential (Hargittai & Sandvig, 2015), this book provides honest insights from researchers who have done the work, with information on lots of trial-and-error processes that are typically hidden behind “Method and Data” sections of finished publications.
SHORT DURATION OF UPPER EXTREMITY LYMPHEDEMA CORRELATES WITH A FAVORABLE CYTOKINE RESPONSE AFTER LYMPH NODE TRANSFER SURGERY
Authors: Rannikko E.H. , Leppäpuska I.-M. , Laukka M. , Saarikko A. , Hartiala P.
Published: September 2022

Vascularized lymph node transfer surgery (VLNT) can provide benefit to lymphedema patients. Cytokines may play a role in the development of lymphedema and in the regeneration of lymphatic vessels after VLNT. Our primary aim was to investigate whether the VLNT patients have a specific cytokine profile. Our secondary aim was to see whether the preoperative lymphedema or severity affects the postoperative cytokine response. Wound exudate was gathered from 18 patients undergoing VLNT on the first and sixth postoperative day (POD). The concentrations of IL-10, TNF-α, TGF-β1 and VEGF-C were analyzed using enzyme-linked immune-sorbent assays. A general score was generated to assess the benefit of the surgery. The changes in cytokine concentrations (1st POD-6th POD) were correlated with the pre- and postoperative lymphedema related factors. A shorter duration of lymphedema preoperatively correlated with an increase in the concentration of IL-10 and TNF-β during the first six PODs (IL-10: r=0.495, p=0.051; TNF-α: r=0.737, p=0.006) and a decrease in the concentration of TGF-s1 (r= -0.613, p=0.020). The increase of the concentration of TNF-α during the first six PODs also correlated with a greater total general score (r=0.775, p=0.005) and hence indicated a better response to the surgery. The patients with a shorter duration of lymphedema preoperatively had a more favorable cytokine response during the first six PODs after VLNT.
Manifestations of ENT Caused By Gastroesophageal Reflux Disease
Authors: Andreea Hagi , Gurgas Leonard , Victor Lupascu Mihai
Published: September 2022

Introduction. The presence of gastric reflux in the pharynx and larynx causes reflux laryngopharyngitis. The incidence of laryngopharyngeal reflux has increased dramatically in recent years, but with the introduction of flexible fiber optic esophagoscopy, evidence-based research on gastroesophageal reflux disease has evolved greatly. Laryngoscopy is the main investigation to be performed to establish the diagnosis of reflux.

Material and methods. This study is both retrospective and prospective, the first being performed on a group of 175 patients, who presented in the ENT outpatient clinic, within the County Emergency Clinical Hospital “St. Andrew the Apostle” Constanta.

The aim of this paper is to evaluate and compare the manifestations of ENT caused by reflux disease but also to establish the correct therapeutic conduct.
Polarized Microscopy Study of 10 Cases of Lichen Sclerosus Using Picro-Sirius Red Stain
Authors: Liliana Mocanu , Elena Munteanu-David Ramona , Sorin Deacu
Published: September 2022

Lichen sclerosus (LS) is a chronic mucocutaneous sclerosis most commonly affecting the genital area, although extragenital localizations have also been described1, with unknown pathogenesis.

Our study aims to analyze the morphopathological aspects of LS through the prism of polarized microscopy and with the help of histochemical information provided by special Van Gieson stain for elastic tissue and Picro-Sirius Red special stain.

Picro-Sirius Red staining allows observation of the type of collagen synthesized in pathological conditions such as LS, as well as the appearance of mature hyalinization through loss of elastic tissue, and also the disappearing of piloerectile muscles.
Burnout y engagement: un análisis desde los turnos laborales en personal asistencial
Authors: Trejos-Torres Luis Carlos , Quiroz González Eliana Yulieth , Castaño-González Esther Julia
Published: September 2022

El objetivo de esta investigación es analizar las diferencias del burnout y el engagement en función de los turnos laborales en el personal asistencial de una institución de salud oncológica. Con el fin de recolectar los datos se utiliza una ficha sociodemográfica para determinar el tipo de turno en que laboran los trabajadores, el Maslach Burnout Inventory-Human Services Survey y el Utrecht Work Engagement Scale-9. La investigación tiene un enfoque cuantitativo y un diseño no experimental. La muestra está conformada por 56 participantes (M = 44, H = 12). Se hacen análisis estadísticos a través del SPSS v.20, estimando medidas descriptivas y se comprueban los supuestos de normalidad K-S (p < 0,05), indicando que el comportamiento de los datos no tiene una distribución normal. Por consiguiente, se lleva a cabo un análisis no paramétrico con el estadístico de Kruskal-Wallis. Los resultados indican que no hay diferencias significativas en el burnout según el turno laboral; no obstante, sí se encuentran diferencias en la dimensión de absorción, X2 = 10,5, p = 0,032, siendo el puntaje más alto el obtenido por el turno diurno combinado (Me = 16,2) y el más bajo el mixto por semanas (Me = 11,5). Estos resultados señalan posibles vías de investigación e intervención alrededor de las variables sociodemográficas y contextuales que pueden tener implicaciones en el burnout y el engagement.
¿Cómo perciben los profesores de educación superior el aprendizaje autorregulado?
Authors: Zander Londoño Sebastián , Roncancio Moreno Mónica
Published: September 2022

Las concepciones sobre el aprendizaje autorregulado en educación superior son determinantes para develar las prácticas de los profesores en relación con el proceso de aprendizaje de sus estudiantes, considerando su historia personal y los elementos del sistema que influyen en la praxis pedagógica. Numerosos análisis han identificado que la percepción del docente sobre el aprendizaje influye radicalmente en cómo aborda sus procesos pedagógicos en educación superior, donde es fundamental reconocer que debe haber una perspectiva que incluya el aprendizaje autorregulado como un modelo transversal de la práctica educativa, que comprenda los factores determinantes para la configuración de estrategias de aprendizaje que respondan a las demandas del sistema educativo. Esta investigación se propuso identificar esas percepciones de los profesores (licenciados) de educación superior acerca del aprendizaje autorregulado. Para esto, se diseñó una entrevista semiestructurada que recoge las principales categorías de la conceptualización del aprendizaje autorregulado, y se hizo un análisis cualitativo de las relaciones categoriales en función de dicha percepción. Se encontró que el aprendizaje autorregulado se percibe como un ideal educativo, en comparación con el aprendizaje autónomo, determinado por la influencia de factores emocionales en la construcción de elementos de autorregulación del aprendizaje.
El TDAH como reto para la educación inclusiva en las universidades
Authors: Granados Ramos Dora Elizabeth , Figueroa Rodríguez Sebastián , López Sánchez Jorge Darío , Pérez Figueroa Luisa Mariana
Published: September 2022

La educación inclusiva universitaria debe dar continuidad a las prácticas educativas desarrolladas en los niveles educativos previos, como la detección y atención de barreras para el aprendizaje entre las que se encuentra el TDAH. El objetivo de la investigación fue describir la presencia y persistencia de indicadores de TDAH en estudiantes universitarios de primer año de la Licenciatura de Psicología. Se realizó un estudio mixto, observacional, descriptivo en el que participaron 210 estudiantes de primer año con edad promedio de 19 años, a los que se les solicitó responder dos instrumentos de autoaplicación: Cuestionario Autoinformado de Cribado del Adulto V1.1. (ASRS V1.1) y MINIPLUS, Módulo W de TDAH. Se encontró que el 50 % de los participantes reportaron algún indicador de TDAH. En el Cribado predominaron las dificultades de atención en 15.7 % y en el MINIPLUS, las dificultades de hiperactividad en 63.8 %. Se observaron modificaciones significativas de la niñez a la adultez (p < 0.001), debido a que 26 participantes, que en la niñez no reportaron dificultades, las señalaron en la adultez. En la comparación de detección de dificultades mediante los dos instrumentos se detectaron 131 participantes sin indicadores de dificultades de atención y 50 participantes sin indicadores de hiperactividad. En conclusión, con estos datos se muestra la importancia de documentar y atender los indicadores de TDAH en estudiantes universitarios, además de considerar otras barreras de aprendizaje, de tal manera que se contribuya al logro de la educación inclusiva en cuanto a condiciones de igualdad para todos los universitarios.