bluuebunny/crossref_metadata_2025 huggingface dataset:
Attenuating Fibrotic Markers of Patient-Derived Dermal Fibroblasts by Thiolated Lignin Composites
Authors: Belgodere Jorge , Son Dongwan , Jeon Bokyoung , Choe Jongwon , Guidry Anna , Bao Adam , Zamin Syed , Parikh Umang , Balaji Swathi , Kim Myungwoong , Jung Jangwook
Published: February 2021

Engineering composite biomaterials requires the successful integration of multiple feedstocks to formulate a final product for functional improvement. Here we engineered biomaterial scaffolds to attenuate the fibrotic phenotype exhibited by high scarring (HS) patient-derived dermal fibroblasts (hdFBs) by valorizing lignosulfonate from waste feedstocks of lignin. We utilized phenolic functional groups of lignosulfonate to impart antioxidant properties and the cell binding domains of gelatin to enhance cell adhesion for poly(ethylene glycol)-based scaffolds. Highly efficient chemoselective thiol-ene chemistry was utilized for the formation of composites with thiolated lignosulfonate (TLS) and methacrylated fish gelatin (fGelMA) in the PEG(poly (ethylene glycol))-diacrylate matrix. Antioxidant properties of lignosulfonate was not altered after thiolation and the levels of antioxidation were comparable to a well-known antioxidant, L-ascorbic acid, as evidenced by DPPH (2,2-diphenyl-1-picrylhydrazyl) and TAC (Total Antioxidant Capacity) assays. Unlike porcine gelatin, fGelMA remained liquid at room temperature and exhibited low viscosities, resulting in no issues of miscibility when mixed with PEG. PEG-fGelMA-TLS composites significantly reduced the differential of five different fibrotic markers (COL1A1, ACTA2, TGFB1 and TGFB1) between HS and low scarring (LS) hdFBs, providing the potential utility of TLS in a biomaterial scaffold to attenuate fibrotic responses.
Assessment of Serum Vitamin D, Folic acid and Vitamin B12 in Congenital Heart Disease Patients in a Teritary Hospital
Authors: Lally Hanna Luke  , Anandhi D  , Shiva Kumar K  , Valli G  , Revathi K  , Binoy Varghese Cheriyan
Published: February 2021

Congenital heart disease patient suffers from malnutrition irrespective of the types of cardiac defects. These children are often admitted in hospitals owing to congenital heart defects. Corrective catherization, proper nutritional intake and counselling can improve the malnutrition. To assess the vitamin status in children with congenital heart disease patients admitted in paediatric general ward of tertiary hospital. The study was a prospective observational study, a total of 100 patients were evaluated for their nutritional deficiency such as serum vitamin D3, folic acid and Vitamin B12 by employing ELISA KITS.  The study observed a significant levels of vitamin D3 and folic acid depletion in congenital heart disease patients. There was no severe depletion of vitamin B12 in the current study. The study had made an insight into the malnutrition status of congenital heart disease patients and recommends consumption of micronutrients in congenital heart defect patients.
GATA transcription factors, SOX17 and TFAP2C, drive the human germ-cell specification program
Authors: Kojima Yoji , Yamashiro Chika , Murase Yusuke , Yabuta Yukihiro , Okamoto Ikuhiro , Iwatani Chizuru , Tsuchiya Hideaki , Nakaya Masataka , Tsukiyama Tomoyuki , Nakamura Tomonori , Yamamoto Takuya , Saitou Mitinori
Published: February 2021

The in vitro reconstitution of human germ-cell development provides a robust framework for clarifying key underlying mechanisms. Here, we explored transcription factors (TFs) that engender the germ-cell fate in their pluripotent precursors. Unexpectedly,SOX17,TFAP2C, andBLIMP1, which act under the BMP signaling and are indispensable for human primordial germ-cell-like cell (hPGCLC) specification, failed to induce hPGCLCs. In contrast,GATA3orGATA2, immediate BMP effectors, combined withSOX17andTFAP2C, generated hPGCLCs.GATA3/GATA2knockouts dose-dependently impaired BMP-induced hPGCLC specification, whereasGATA3/GATA2expression remained unaffected inSOX17,TFAP2C, orBLIMP1knockouts. In cynomolgus monkeys, a key model for human development,GATA3,SOX17, andTFAP2Cwere co-expressed exclusively in early PGCs. Crucially, the TF-induced hPGCLCs acquired a hallmark of bona fide hPGCs to undergo epigenetic reprogramming and mature into oogonia/gonocytes in xenogeneic reconstituted ovaries. By uncovering a TF circuitry driving the germ line program, our study provides a paradigm for TF-based human gametogenesis.
Things Are How They Are Because of How They Got That Way: Thoughts from the Beach, on 50 Years of Geographical Analysis
Authors: O'Sullivan David
Published: February 2021

© 2019 The Ohio State University The subtitle of Geographical Analysis is “An International Journal of Theoretical Geography”, yet in fifty years of publication little has been published in the journal that fits that remit. In this short commentary I reflect on the nature of theory and explanation in geography and call for more sustained engagement with these themes in the pages of the journal in the years to come.
An outbreak investigation of Legionella non-pneumophila Legionnaires’ disease in Sweden, April to August 2018: Gardening and use of commercial bagged soil associated with infections
Authors: Löf Emma , Chereau Fanny , Jureen Pontus , Andersson Sabina , Rizzardi Kristina , Edquist Petra , Kühlmann-Berenzon Sharon , Galanis Ilias , Schönning Caroline , Kais Madeleine , Tideholm Nylén Anne , Wallensten Anders , Roth Adam ,   on behalf of the National Outbreak Investigation Team
Published: February 2021

In early June 2018, an increase in non-travel-related cases of Legionella non-pneumophila Legionnaires’ disease (LD) was observed in Sweden and a national outbreak investigation was started. Outbreak cases were defined as notified confirmed or probable cases of L. non-pneumophila LD, with symptom onset after 1 April 2018. From April to August 2018, 41 cases were reported, 30 of whom were identified as L. longbeachae. We conducted a case–control study with 27 cases and 182 matched controls. Results from the case–control study indicated that gardening and handling commercial bagged soil, especially dusty dry soil, were associated with disease. L. longbeachae was isolated in soils from cases’ homes or gardens, but joint analysis of soil and human specimens did not identify any genetic clonality. Substantial polyclonality was noted between and within soil samples, which made finding a genetic match between soil and human specimens unlikely. Therefore, whole genome sequencing may be of limited use to confirm a specific soil as a vehicle of transmission for L. longbeachae. Handling soil for residential gardening was associated with disease and the isolation of L. longbeachae in different soils provided further evidence for Legionella non-pneumophila infection from soil.
IMPROVEMENT OF METHODICAL COMPETENCE OF MUSIC TEACHERS IN COMPREHENSIVE SECONDARY EDUCATION INSTITUTIONS
Authors: Provorova Ye.
Published: February 2021

The article is devoted to the problem of improvement of methodological competence of music teachers in general secondary educational institutions through a well-thought-out system of school methodical work. The definition ofsuchconceptsas“professionalcompetenceofamusicteacher” and“methodicalcompetenceofamusicteacher” is proposed. Under the professional competence of a music teacher we understand the holistic characteristics of the personality of the specialist with the already-formed set of competencies that allow him to perform his professional functions effectively, to update and enrich his knowledge constantly, to develop new skills according to the level of science and technology, to be ready for social changes, to enjoy his professional activities. In its turn, the methodical competence of the teacher-musician is interpreted as an integral characteristic of personality, which determines the ability to solve professional problems in situations of real practical musical-educational activities, corresponds to the main types of methodical activities of music teachers and is a set of components such as orientational (professional orientation), cognitive (methodical knowledge), operational-active (methodical skills), personal (professionally significant personal qualities) and social-behavioral (experience). The functions of methodical work in the institution of general secondary education (planning, organizational, diagnostic, prognostic, modeling, corrective functions) and criteria of optimality of results of teacher’s methodical work (criterion of efficiency, criterion of rational spending time and economy, satisfaction of the teacher with the work, criterion of effective methodical work) are studied out. The characteristics of traditional and innovative methods, forms and technologies of improving the methodological competence of music teachers in general secondary education are given, which include concilium, round table, methodical ring, auction of pedagogical ideas, business game, week of pedagogical sciences, pedagogical workshop, master classes , pedagogical mosaic, creative laboratory, discussion-aquarium, debates, information and communication technologies, etc.
THE ESSENCE OF EDUCATIONAL PARADIGMS AND POLYPARADIGMAL MANIFESTATIONS IN MULTIDIMENSIONAL PEDAGOGICAL REALITY AND PERSONAL SELF-REALIZATION OF STUDENTS IN E-LEARNING
Authors: Miier M.
Published: February 2021

The article examines the educational paradigm as a genesis indicator of changes in the educational field caused by social development, paradigm as a result of the implementation of integration processes. Besides, the personal self-realization of students as a manifestation of the student-centric paradigm is studied. Іn accordance with the objectives of the study, the following is performed. It summarises the key ideas of paradigms of traditional pedagogy (knowledge, ZUN, scientific- technocratic, paradigm of explanatory-illustrative learning) and people- oriented paradigms (child-centric, anthropological, cognitive, pragmatic, humanitarian, humanistic, cultural, paradigms of developmental and adaptive learning). It is established that paradigm analysis of modern education should be carried out in two directions: 1) to reveal its polyparadigmal character; 2) to provide a thorough consideration of the didactic features of the organizing the educational process within the specific educational paradigm. Considering the above mentioned matter in the article, the examples of polyparadigmal manifestations of multidimensional phenomena and processes in pedagogical reality are given. Didactic features of organising educational process in realisation of student-centered paradigm are also revealed. It is characterised such didactic tools as topic-presentation matrix and author’s music-markers of the beginning and end of the learning process (lectures, seminars, lessons, etc.). The self-realization of students with the use of these means is investigated.

The complex of research methods is used in the work: general scientific (analysis, synthesis, comparison, systematization, generalization) and empirical (observations, discussions, questionnaires). The complex of research methods is used in the work: general scientific (analysis, synthesis, comparison, systematization, generalization) and empirical (observations, discussions, questionnaires).

110 respondents were involved in the study. These are full-time and part-time students. Institution of higher education: Borys Grinchenko Kyiv University.

As a result of the study it is established a significant potential of the studied tools for organization of the learning process; for emotional adjustment of students to the process of learning and for recreation; for their personal self- realization on the basis of imitation of the creative of Others.
Combined application of organomineral and mineral fertilizers in the fertilization system of winter wheat on the southern black soil of the Lower Don
Authors: Ermilov Artem Vladimirovich , Kamenev Roman Aleksandrovich , Solodovnikov Anatoly    Petrovich , Maksimchuk Vladimir Nikolaevich
Published: February 2021

The article presents an analysis of the determination of the effectiveness of mineral and organic fertilizers on the yield of winter wheat grain. The studies were carried out in 2017–2020 in the Rostov region on the southern chernozem. The object of research was the Doneko winter wheat variety. The predecessor is corn for grain. Ammonium nitrate, ANP fertilizer (16-16-16) and urea were used as mineral fertilizers, which were applied in the fertilization system of winter wheat and acted as a background option in the experimental scheme. ANP fertilizer (16-16-16) was introduced when sowing winter wheat, ammonium nitrate - scattered over thawed-frozen soil and carbamide in the heading phase by foliar method. Organomineral fertilizers were represented by the following types: Ruther, Leili 2000, Siamino Pro, Gumiful Pro, Soft Guard and Double Wine MKR (monocaliphosphate) produced by Biokepharm (Switzerland). The raw material for the production of organomineral fertilizers was the algae of the warm seas Laminaria. In the field experiment, the options for the joint application of foliar application and pre-sowing seed treatment with organomineral fertilizers were also studied. The control was the option without mineral fertilizers and the option with the background of the use of mineral fertilizers (farm fertilization system).

It was found out that the use of organic fertilizers Ruter (0.5 or 0.25 l / t) and Leyli (0.25 l / t) for seed treatment before sowing, the use of Soft Guard (0.2 l / ha) and Gumiful Pro ( 0.2 l / ha) in the spring tillering phase and in the flag leaf phase against the background of sowing nitroammophoska at a dose of N32P32K32, random fertilizing on thawed-frozen soil with ammonium nitrate at a dose of N40 and the use of carbamide in the heading phase at a dose of N20 increased grain yield on average for 2018–2020 compared with the control (fertilization system of the farm) by 0.73 t / ha, or 23.0%. The maximum yield increase from the root-forming agent Ruther, used for pre-sowing seed treatment, reached 0.36 t / g, or 11.3%.
Trends of the energy and protein value of hylage from legumes in the Republic of Tatarstan
Authors: Krupin Evgeny Olegovich , Tagirov Marsel Sharipzyanovich , Askarova Adelya Ayratovna
Published: February 2021

The results of the analysis of the dynamics of energy and protein nutritional value of haylage from perennial legumes harvested from plant raw materials in the territory of the Republic of Tatarstan in the period from 1993 to 2018 are described. The long-term average value of the studied indicator was 9.52 MJ / kg, which is 5.54% higher than the norm. The highest content of exchangeable energy was noted in 1996 - 9.67 MJ / kg, which is 1.58% higher than the long-term average. The lowest content of exchangeable energy was established in 2009 (9.36 MJ / kg). The long-term average value of the net energy level of lactation was 1.96 MJ / kg, which is 9.68% higher than the norm. The maximum was observed in 2017 and amounted to 2.17 MJ / kg, and the minimum - in 2001 (1.65 MJ / kg), when it was 23.97% below the norm. It was found that the average long-term value of the level of digestible protein in haylage was 111.31 g / kg, which is 1.78% higher than the norm. The highest content of digestible protein was found in 2010 (17.21%). The smallest value was recorded a year earlier, in 2009 and amounted to 95.64 g / kg, which, respectively, is lower than the average long-term value and the value of the norm by 14.08 and 12.56%, respectively.
Technology for the production of pates by replacing raw meat with vegetable components
Authors: Nikolaev Dmitriy Vladimirovich , Bozhkova Svetlana Evgenievna , Zabelina Margarita Vasilyevna , Zabelina Margarita Vasilyevna , Smutnev Petr Vladimirovich , Preobrazhenskaya Tatyana Stanislavovna , Tyurin Igor Yurievich
Published: February 2021

The article is devoted to the development of functional meat food products made by partially replacing beef and poultry meat with lentils and carrots. When developing the pate, a partial replacement of grade 2 beef and chicken fillet with lentils and carrots is provided. A technology for the production of pate with vegetable raw materials based on the use of sprouted lentils obtained by processing it with electroactivated solutions of sodium and ammonium chlorides has been developed. Studies of functional, technological and organoleptic parameters of the developed pates have been conducted, which have shown that the proposed pate recipe allows replacing expensive ingredients – grade 2 beef and chicken fillet with lentils and carrots, to get a product that is not inferior in quality to the standard pate preparation technology. The article describes the detailed amino acid composition of the pate under study and compares it with the reference protein.
Rational methods of treatment of cows with acute postpartum purulent-catarrhal endometritis
Authors: Semivolos Aleksander Mephodyevich , Bryukhanova Anastasiya Andreevna
Published: February 2021

The comparative therapeutic efficacy of “Enroflon®” and “Geomycin®F”, which have foaming properties, for the treatment of cows with acute purulent-catarrhal endometritis, is considered. Faster clinical recovery and uterine involution occurred in the experimental group of cows treated with “Enroflon®”. The recovery time of the animals was 1.19 days shorter compared to the use of “Geomycin®F”. For 90 days of the experiment, fertilization occurred in 100% of cows with an insemination index of 1.56 after treatment of animals with “Enroflon®”. Whereas after the application of “Geomycin®F” fertilization after insemination was 88.88% with an insemination index of 2.12.
Analytical study of the intensification of the mass transfer process during inactivation of soybean grain in an ultrasonic installation
Authors: Rudik Felix Yakovlevich , Morgunova Natalia Lvovna , Makarov Denis Vyacheslavovich
Published: February 2021

The article is devoted to improving the effectiveness of technological impact on soy in order to remove anti – nutritional substances from it-trypsin inhibitors and urease enzymes. This is achieved by intensifying the mass transfer during extraction by ultrasonic pulsating micro-flows and cavitation with the formation of the oxidizer hydrogen peroxide H2O2. The developed technical means provide high inactivation rates and increase the productivity of the process.
La narrativa experiencial como propuesta teórico-metodológica al campo de la comunicación y su aplicación en dos grupos de juego de Calabozos y Dragones
Authors: Rangel Jiménez Mauricio
Published: February 2021

El presente artículo busca dar a conocer la metodología utilizada para analizar un juego de rol como lo es Calabozos y Dragones, el desarrollo de la investigación, su aparato teórico metodológico, así como sus respectivos resultados y conclusiones para encontrar los elementos de conformación de la narrativa experiencial en un medio de comunicación particular como lo es Calabozos y Dragones.

La denominada narrativa experiencial, en este caso en específico, operó como metodología de análisis que arrojó como resultado la identificación de los elementos fundamentales para la generación de momentos significativos en la mente de los jugadores de Calabozos y Dragones.

Como parte de los resultados, se encontró que las interacciones de los jugadores y de los personajes con sus entornos son los que predominantemente generan la experiencia, es decir, por el lado de los jugadores es la interacción entre ellos, con los dados, hojas de personaje, reglas y música ambiental lo que determina la experiencia en su línea de tiempo; mientras que por el lado de los personajes, es el conjunto de interacciones en el ambiente virtual lo que determina sus momentos significativos que generan la narrativa experiencial en conjunto.
Identification of Global Warming Contribution to the El Niño Phenomenon Using Empirical Orthogonal Function Analysis
Authors: Julianto Mochamad Tito , Dhimas Septian , Sopaheluwakan Ardhasena , Nurdiati Sri , Septiawan Pandu
Published: February 2021

Sea surface temperature (SST) is identified as one of the essential climate/ocean variables. The increased SST levels worldwide is associated with global warming which is due to excessive amounts of greenhouse gases being released into the atmosphere causing the multi-decadal tendency to warmer SST. Moreover, global warming has caused more frequent extreme El Niño Southern Oscillation (ENSO) events, which are the most dominant mode in the coupled ocean-atmosphere system on an interannual time scale. The objective of this research is to calculate the contribution of global warming to the ENSO phenomenon.  SST anomalies (SSTA) variability rosed from several mechanisms with differing timescales. Therefore, the Empirical Orthogonal Function in this study was used to analyze the data of Pacific Ocean sea surface temperature anomaly. By using EOF analysis, the pattern in data such as precipitation and drought pattern can be obtained. The result of this research showed that the most dominant EOF mode reveals the time series pattern of global warming, while the second most dominant EOF mode reveals the El Niño Southern Oscillation (ENSO). The modes from this EOF method have good performance with 95.8% accuracy rate.
PENGARUH PENGGUNAAN GADGET TERHADAP PERKEMBANGAN BICARA DAN BAHASA ANAK USIA 3-5TAHUN
Authors: Anggrasari Anggun Pranessia , Rahagia Rasi
Published: February 2021

Gadget merupakan salah satu perkembangan teknologi dan komunikasi yang tanpa disadaritelah mempengaruhi setiap aspek kehidupan manusia, termasuk anak-anak. Ketika menggunakangadget, anak menjadi kurang bersosialisasi dan berkomunikasi dengan orang lain. Hal tersebutmenyebabkan anak kurang optimal mendapatkan stimulus yang tepat sehingga mengalamiketerlambatan dalam aspek perkembangan bicara dan bahasa. Selama tahun 2013 sampai pertengahantahun 2015 terjadi peningkatan masalah keterlambatan tumbuh kembang pada anak yang ditemukanmelalui Deteksi Dini Tumbuh Kembang. Tujuan dari penelitian ini adalah untuk menganalisispengaruh penggunaan gadget terhadap perkembangan bicara dan bahasa pada anak usia 3-5 tahun.Penelitian ini termasuk jenis penelitian survey analitik menggunakan pendekatan crosssectional. Populasi penelitian berjumlah 60 responden dimana keseluruhannya akan menjadi sampelpenelitian (total sampling). Instrumen penelitian menggunakan kuesioner penggunaan gadget danKPSP. Data Yang telah dikumpulkan dianalisis menggunakan uji Chi-Square dngan kriteriasignifikan p-value< 0,05.Dari hasil analisis diperoleh nilai p-value 0,001 (p-value< 0,05) yang berarti terdapat pengaruhyang signifikan antara penggunaan gadget terhadap perkembangan bicara dan bahasa pada anak usia3-5 tahun. Hal ini mendasari bahwa pentingnya memberikan permainan edukatif kepada anak danmemberikan stimulasi selama mereka bermain.
HUBUNGAN PARITAS DENGAN KEJADIAN INKONTINENSIA URIN-STRES PADA WANITA USIA 40-45 Tahun
Authors: Suminar Ervi , Islamiyah Lailatul
Published: February 2021

paritas tinggi biasanya saat batuk, tertawa, bersin, berolahraga akan mengeluarkan urin dalam jumlahsedikit akibat proses persalinan yang pernah dialami. Tujuan penelitian ini adalah untuk mengetahuihubungan Paritas dengan Kejadian Inkontinensia Urin-stress pada Wanita Usia 40-45 Tahun di DusunJaddih Timur.Jenis penelitian ini adalah penelitian analitik dengan desain cross sectional. Populasi penelitianadalah seluruh wanita usia 40-45 Tahundi Dusun Jaddih Timur Desa Jaddih sebanyak 40 responden.Besar sampel sebanyak 36 responden dengan teknik pengambilan menggunakan Purposive sampling.Pengumpulan data menggunakan kuesioner.Uji statistik yang digunakan adalah Uji Fishers Exact Testdengan ɑ = 0,05.Hasil penelitian menunjukkan 16 wanita dengan grandemultipara yang tidak mengalamiinkontinensia urin stres sebanyak 0 (0%) dan yang mengalami inkontinensia urin sebanyak 16(100%). Hasil uji Fishers Exact Test di dapatkan p value = 0,002 <ɑ (0,05), berarti H0 di tolak dan H1di terima yang berarti ada hubungan paritas dengan kejadian inkontinensia urin-stres pada wanita usia40-45 tahun.Berdasarkan hasil penelitian, maka disarankan alternatif yang dapat digunakan untukmenangani atau mencegah inkontinensia urin-stres pada wanita yaitu dengan mengajarkan wanitauntuk melakukan latihan dasar pelvis untuk menguatkan otot-otot rangka pada dasar pelvis .Kata Kunci: Paritas, Inkontinensia Urin-Stres
Hakekat Penjatuhan Pidana Pengawasan yang diberikan oleh Hakim terhadap Anak yang Berhadapan dengan Hukum guna mewujudkan Keadilan
Authors: Hapsari Ifahda Pratama
Published: February 2021

Kekuasaan Kehakiman merupakan salah satu unsur penting dalam struktur ketatanegaraan yang menjadi bagian dari sistem Hukum suatu negara. Dalam konsep Negara hukum termasuk pula konsep Rechtstaat, maupun the rule of law serta nomokrasi islam. kekuasaan kehakiman menjadi tiang penyangga suatu negara hukum bekerja. dalam negara hukum kekuasaan kehakiman dituntut dituntut harus bebas atau merdeka dari pengaruh siapapun terpisah dari kekuasaan legislatif dan yudikatif. Pada dasarnya, pidana pengawasan yang diterapkan hakim kepada  anak yang berhadapan dengan Hukum  harus mencerminkan keadilan. kata pidana pada umumnya tidak lazim diberikan kepada anak. maka diharapkan pemberian sanksi pidana atau hukuman diganti dengan pemaknaan yang lebih baik yaitu dengan melakukan pengawasan, yang jauh lebih efektif diterapkan agar tidak menimbulkan stigmatisasi terhadap anak yang sedang berhadapan dengan hukum.
HARMONISASI PERATURAN DAERAH KABUPATEN/KOTA PASCA PUTUSAN MAHKAMAH KONSTITUSI NOMOR 137/PUU-XIII/2015
Authors: Roqib Muhammad
Published: February 2021

Constitutional Court has issued Verdict No. 137/PUU-XIII/2015 about withdrawing the Governor’s authority in cancelling regency/city regulation. The Constitutional Court has tested Article No. 251 (2), (3), (4), and (8) on the Constitution No. 23 of 2014 about Local Government. By this verdict, the only way to issue the cancellation of the regency/city regulation is through judicial review mechanism of Supreme Court (MA). Only after the Governor’s authority in cancelling the regency/city regulation has been  revoked, a problem appears in how to ensure the harmonization between the regency/city regulation and another regulation. This research uses statute approach, examining all of the constitutions with examined law issues and conceptual approach which starts from points of view and developing doctrines in science of law. Based on this research result, it is discovered that during the implementation of the Verdict of the Constutional Court No. 137/PUU-XIII/2015 did not deprive the control of central government towards local government, including the establishment of regency/city regulation. Governor as representative of central government in the region was given an authority to supervise preventively towards the establishment of regency/city regulation. By maximum preventive supervision, it would harmonize between regency/city regulation and another constitutional regulation.
In vitro effectiveness of some plant species as green manure for the control of stem and bulb nematode (Ditylenchus dipsaci)
Authors: YAVUZASLANOĞLU Elif , AKSAY Gamze , ÇETİNKAYA Ahmet
Published: February 2021

Stem and bulb nematode, Ditylenchus dipsaci (Kühn, 1857) Filipjev, 1936, is a plant parasitic nematode that causes significant losses in plant production in the world. One of the promising methods for control of soil-borne diseases and pests that do not accumulate in nature is green manure application. Studies on the effectiveness of green manure on stem and bulb nematode are limited. In this study, the activity of 4 plant species from Brassicaceae family and one Tagetes patula L. variety on stem and bulb nematode was investigated in vitro. In the study, rates of motionless nematodes were recorded in the water and sand medium in 4 days and 11 days in five plant species. The efficiency of the plant species was increased over time. In all treatments in the study, the highest rate of motionless nematodes was obtained with arugula. On the 4th and 11th days in the water medium, 84.1% and 95.7% of motionless nematodes were obtained, respectively, while in the sand medium, the rate of motionless nematodes was 60.2% and 86.1%. Following the arugula, Tagetes patula showed activity at the rates of 72.9% and 98.3% in the water medium and 40.9% and 81.9% in the sand medium on the 4th and 11th days, respectively. Radish was also found promising with 62.5% and 94.2% in water medium, 59.2% and 80.9 in the sand medium, on the 4th and 11th days, respectively. The data obtained in the study provided preliminary data for green manure applications under field conditions.
THE EFFECT OF APPLYING SOCRATIVE ON STUDENTS’ READING ABILITY
Authors: Fatmawaty Riryn , Sholihah Sofi Nurhidayatus
Published: February 2021

This study aimed to determine the impact of the application of socrative to the reading ability of students in industrial 4.0 era, where anything was done using the internet and computers. The method used in this study was the pre-experimental type One Group Pretest-Posttest. This method used a class that was used as the object of research. This research was conducted at SMK 1 Baureno located on Jl. Raya Kepohbaru Department No. 258, Baureno, Plumbungan, Bojonegoro. The object of this research was the 10th grade computer and network engineering students at SMK 1 Baureno. The number of students was 34 consisting of 17 male students and 17 female students. This research was conducted on February 5 through March 11, academic year 2019/2020. There were three activities carried out, namely pretest, treatment and posttest. The hypothesis accepted in this study was the alternative hypothesis (Ha). Because the results of this study indicated that the t-test of 34 students was 17,07 with a significant level of t-table 0,05. This mean that there were differences in the ability of students before and after treatment was given. And from the results of questionnaires that had been done that 10th grade students of computer and network technique at SMK 1 Baureno prefered to read online (using socrative) rather than reading offline. Keywords: Reading, socrative
PSYCHOLOGICAL PROBLEMS IN SPEAKING ENGLISH OF THE STUDENTS OF VOCATIONAL SENIOR HIGH SCHOOL
Authors: Anam Mukhtarul , Tantri Tantri
Published: February 2021

The purpose of the research is to know the students’ psychological problems, and to know the efforts of the students to overcome their psychological problems. The research was conducted in SMKN 1 Lamongan at OTKP. The research is qualitative research. It used an observation and a semi-structured interview as a technique to collect the data. Based on the research, the researcher found that the students felt anxious, shy, fear of making mistakes and the students also got a lack of confidence when they were speaking in front of the class. The efforts to overcome their psychological problems were as follows. The students should have the self-confidence to speak, the student should master many vocabularies, and more practices speaking in English, the teacher should give motivation to the students and encourage a habit and accustom the students to use English. Keywords: Speaking, psychological problems
Miniaturization of quadrature stub directional couplers.
Authors:   Ural Federal University named after the first President of Russia B.N.Yeltsin, Mira str., 32, Yekaterinburg 620002, Russia, Letavin D.A.
Published: February 2021

The method of designing stub quadrature couplers with reduced dimensions relative to the standard design is considered. This technique is based on replacing quarter-wave sections of a microstrip transmission line (MTL) with low-pass filters (LPF), with equivalent frequency characteristics in the vicinity of the central frequency of the device. In addition, the circuit and design implementations of compact couplers with a controlled operating frequency and different wave impedances of the supply lines of the coupler are considered.
What Languages are in Names? Exploring the Languages in Church Names in Ghana
Authors: Yaw Akoto Osei , Afful Joseph Benjamin A.
Published: February 2021

Several studies over the years have employed the rhetorical question "What is in a name?" to uncover the semantic-pragmatic imports of names. This paper examines church names (ecclesionyms) which constitute part of the religio-onomastic landscape of Ghana to discover the various languages embedded in them. To achieve this task, we gathered names of churches from ‘online’ (websites of associations of Christian churches) and ‘offline’ sources (posters, signages and billboards). We manually searched the data and identified all languages embedded in the church names. Guided by Akoto’s (2018) global-local model of language choice, the analysis showed that churches in Ghana generally adopt three global languages (Hebrew, Greek and Latin), a glocal language (English) and three local languages (Akan, Ewe and Ga). It is argued that the status of the global, glocal and local languages as canonical/biblical languages, an ‘ethnically neutral’ language and ‘Ghanaian majority’ languages respectively enable the churches to foreground their uniqueness. Implications for language planning in religion are discussed. Keywords: church names, ecclesionym, glocal language, identity, language choice
Spanish and Italian Diminutives Compared: Two Alternatives of a Single Diasystem
Authors: Ryan John M. , Parra-Guinaldo Víctor
Published: February 2021

The relexification of diminutives has been one of the most productive ways to create new words in the Romance languages. The phenomenon is defined as the historical reanalysis of a lexical item composed of root plus diminutive suffix, whereby the original semantic value of the suffix is bleached over time and its combined form is subsequently reanalyzed as part of a new single morphological root carrying new meaning. This study provides a quantitative lexicographic analysis of the entirety of diminutives that have relexified in the history of Italian. When compared to results for Spanish by Ryan and Parra-Guinaldo (2016), data of this study suggest that Italian followed a very different trajectory of diminutive relexification from Latin than that for Spanish. Specifically, Italian appears to have developed a preference for the alternate ad hoc diminutive suffixes -ino/a and -etto/a (based on non-diminutive Latin forms) at a much earlier period than did Spanish, allowing for greater absorption and the time necessary for relexification. Contrastively, lexicographic data for Spanish suggest that Spanish instead continued to favor reflexes of the original Latin diminutive suffixes. The reasons proposed for this divergence is the relatively early colonization of the Iberian Peninsula and continued preference for traditional Latin diminutive endings over innovative endings that were being adopted Empire-wide, beyond Castile, including other regions of Hispania Keywords: morphology, lexicon, diminutives, Italian, Spanish
Development of binder system for casting of titanium powder parts under pressure: foreign and domestic experience. Part
Authors:   Bauman Moscow State Technical University, Semyonov A.B. , Muranov A.N. ,   Institute of Design and Technology Informatics of RAS, Kutsbakh A.A. ,   Bauman Moscow State Technical University, Krotov D.M. ,   Bauman Moscow State Technical University, Logachev I.A. ,   JSC "Kompozit", Semyonov B.I. ,   Bauman Moscow State Technical University
Published: February 2021

The main requirements to the composition of a polymer component mixture are determined, the optimization method of a binder system that is used when casting shaped metal powder parts is discussed.
Taxonomic review of species of the Stachys section Candidae (Lamiaceae)
Authors: Krestovskaya T. V.
Published: February 2021

A taxonomic review of the Stachys L. section Сandidae R. Bhattacharjee is given. The keys for determination of the species and vareties are made. The section comprises 5 species cllassified into 2 subsections: Сandidae and a new monotypic subsection Stenophyllae Krestovsk. Two new nomenclatural combinations in the rank of varieties: Stachys iva Griseb. var. macedonica (Micevski) Krestovsk. and S. spreitzenhoferi Heldr. var. virella (D. Perss.) Krestovsk. are published, the latter in a new rank. The presented information includes main synonyms, type citations, ecology and distribution data. S. candida Bory et Chaub., S. chrysantha Boiss. et Heldr., S. spreitzenhoferi Heldr. are endemics of the southern Greece, S. iva Griseb. is endemic of the northern Greece and Republic of Macedonia, S. saxicola Coss. et Balansa — endemic of Marocco and Algeria.
A new species of the genus Thymus (Lamiaceae) from North-Western Caucasus
Authors: Vasjukov V. M. , Popovich A. V.
Published: February 2021

A new species Thymus elenevskyi Vasjukov is described from the North-Western Caucasus.
New taxa in Arundinella and Calamagrostis (Poaceae) from the Russian Far East
Authors: Probatova N. S.
Published: February 2021

Calamagrostis are described from the Russian Far East. Chromosome numbers are reported for two new taxa. Calamagrostis burejensis Prob. et Barkalov, 2n = 28 (sect. Calamagrostis), C. zejensis Prob., 2n = 28 (sect. Deyeuxia), and C. × amgunensis Prob. (C. amurensis Prob. × C. neglecta (Ehrh.) G. Gaertn., B. Mey. et Scherb. s. l.) are described from the Amur River basin (Amur Region or Khabarovsk Territory); Arundinella rossica Prob. (sect. Hirtae) and Calamagrostis kozhevnikovii Prob. et Prokopenko (sect. Calamagrostis) from Primorye Territory.
Nomenclatural novelties in the family Cruciferae (Brassicaceae) of the Russian flora
Authors: Dorofeyev V. I.
Published: February 2021

A new variety, Alyssum obovatum (C. A. Mey.) Turcz. var. paradoxum Serg., var. nova, and a new nomenclatural combination, Arabidopsis kamchatica (Fisch. ex DC.) A. P. Iljinsk. comb. et stat. nov., are validly published, the latter with an avowed authorship of A. P. Iljinska.
New combination and new location Gagea reticulata var. robusta comb. et stat. nov. (Liliaceae)
Authors: Krasovskaya L. S.
Published: February 2021

The status of Gagea robusta Zarrei et Wilkin is revised and a new combination, G. reticulata var. robusta (Zarrei et Wilkin) Krassovsk. comb. et stat. nov., is published in accordance with morphological data. Previously, this taxon was involved in the molecular phylogenetic study of the genus Gagea under the designation «G. helicophylla Levichev» (ined.). The new localities of G. reticulata var. robusta in Turkmenia (Badkhyz, Kopetdag) and Iran are cited.
Checklist of the genus Corydalis section Dactylotuber (Fumariaceae)
Authors: Mikhailova M. A.
Published: February 2021

A full-scale checklist of the Corydalis DC. sect. Dactylotuber Rupr. in Asia and North America is compiled for the first time. Information on the types of both accepted names and main synonyms, details of ecology and distribution are presented. Lectotypes of 6 names are designated.
The effects of School location on students’ academic achievement in senior secondary physics based on the 5E learning cycle in Delta State, Nigeria
Authors: Abamba Ikechuku
Published: February 2021

This study examined the effects of school location on secondary school students’ academic achievement in Physics based on the 5E learning cycle. The design of the study was a non – randomized prêt-test, post-test control group quasi-experimental design. The population of the study was 66,345. Two hundred and forty-three students were sampled from six schools.  Four hypotheses were tested at 0.05 level of significance. The hypotheses state that there is no significant difference in mean achievement scores in Physics between urban and rural students taught using 5E leaning cycle among others. The statistical tools used were mean, standard deviation and Analysis of Covariance (ANCOVA) were used in testing the hypotheses formulated. The result amongst others showed there is no significant difference between rural and urban students’ achievement taught using 5E learning circle (Fcal. (113) = F crit (0.005), p>0.05). Based on the findings, it was recommended among others, that 5E learning cycle be adopted in Nigeria secondary schools as a teaching method and that faculties of education in various schools of higher learning should ensure that 5E learning cycle is included as a method of teaching Physics
النـظـرة التأملية في شعـر ابن جبير الأنـدلسي
Authors: ATTIYA Bushra abd attiya
Published: February 2021

يتناول البحث دراسة الشعر التأملي لدى ابن جبير الأندلسي، ويبدأ بالوقوف على دلالة لفظة التأمل في كتب اللغة والأدب، فـضلاً عـن بيان دلالتها لدى كـل من الفلاسفة وعـلم النفـس، ومن ثم يعرج على تتبع نزعة التأمل لدى الشعراء في العصور السابقة،بدءاً من عصر ما قـبل الإسلام حتى عـصر ابن جبـير مـوردين الشـواهـد الشعـرية التي تظهر ملامح النزعة التأملية في الشعـر العـربي.
وقـد قـسم البحث إلى محـورين تناول الأول منهـما دوافـع النظرة التأملية في شـعـر أبن جبير وتمثلت في تجارب الحياة، والاغـتراب، والزهد، والحكمة، أما في المحور الثاني فقد عرضنا السمات الفنية للشعر التأملي، وكان أبرزها الوقوف عند البناء اللغوي من حيث الألفاظ المفردة والتراكيب المستعملة، كما وقفنا عند الصورة الشعرية وأنواعها التي اعتمدها ابن جبير في بث نظرته التأملية.
وظهر من البحث أن النظرة التأملية لدى الشاعر ابن جبير الأندلسي بثت في شعره على هيئة أبيات شعـرية ضمـن أغـراض شعـره المختلفة، فضلا عن ورودها في مقـطعات شعرية، وقد اتسـمت نظـرته التأملية بالترتيب المنطقـي والسـمة العقـلية والاتعاظ من تجارب الحياة، وكان للمـوازنة بين العقـل والعاطفة دورها في صياغة شعره التأملي، فضلا عن توظيفه للاستدلال وأسلوب الحجاج وقد صاغ كل ذلك في نصوص شعرية أظهرت عـمق تأثر الشاعر بأحداث مجتمعه ودوره في توجيهه .
Resveratrol-Zinc Nanoparticles for COVID-19 Management: Potential Other Inflammatory, Immunologic and Oncologic Benefits.
Authors: Kelleni Mina
Published: February 2021

A peer reviewed published version is found here: https://www.sciencedirect.com/science/article/pii/S075333222100411X?via%3Dihub In this manuscript we provide the scientific basis to adopt a novel combination of two widely available nutraceuticals; resveratrol and zinc in management of COVID-19 recommending their administration using a nano-carrier based drug-delivery system. Resveratrol, a well-known antioxidant and anti-inflammatory triphenolic stilbene, is abundant in red grapes, red wine, dark chocolate, and peanut butter. Alternatively, pterostilbene-zinc combination might be also considered for clinical trials. We recommend conducting prompt clinical trials to assess the potential of the suggested combinations as a monotherapy for mild COVID-19 with a potential to prevent its progression to moderate-severe disease for which we also recommend its trial as an adjuvant therapy. Furthermore, he suggested combinations might also possess a pharmacotherapeutic potential that exceeds COVID-19 to various inflammatory, immunologic, and oncologic diseases.
peranan bapak dalam pembinaan karakter remaja
Authors: siregar benget
Published: February 2021

Berdasarkan pokok masalah diatas, maka yang menjadi tujuan penulis sebagai sasaran dalam penulisan karya ilmiah ini, yaitu: Pertama, agar setiap orang tua memahami peranan mereka dalam membimbing/membina anak remaja. Kedua, agar anak-anak remaja dari orang tua dapat memiliki karakter yang baik. Tujuan penulisan karya ilmiah ini adalah untuk mengetahui peran seorang bapak dalam membina anak. Penelitian menggunakan jenis kualitatif yang bersifat studi pustaka (library research), atau pengumpulan data melalui buku-buku dan internet.Peranan bapak dalam pembentukan karakter remaja sangatlah diperlukan karena tugas seorang bapak adalah bertanggung jawab terhadap seluruh anggota keluarganya. Pada masa remaja adalah dimana para remaja sedang mencari jati dirinya, mereka sering ikut-ikutan, mencoba-coba dan lain sebagainya. Sehingga pada masa inilah remaja perlu pendampingan serta arahan bagi diri mereka. Tidak jarang sering kali para remaja mencontoh dari apa yang mereka lihat dan yang mereka dengar dalam kehidupan sehari-hari. Untuk itu, peranan seorang bapak sangatlah di perlukan dalam membentuk karakter remaja.Peran orang tua menjadi penentu kehidupan masa remaja anak. Orang tua yang dapat mengerti dan memahami perannya dengan baik akan menuntun remaja kepada jalan yang benar seperti yang dikehendaki oleh Tuhan sebaliknya, orang tua yang tidak memahami perannya dengan baik di dalam keluarga akan kehilangan anak remajanya di era globalisasi ini.
ABD23: MHC Class I H-2Kbm3- EQYKFYSV-2C TCR complex: convergence diagnostics of number density
Authors: Antipas Georgios S.E.
Published: February 2021

ABD23: MHC Class I H-2Kbm3- EQYKFYSV-2C TCR complex: convergence diagnostics of number density
Neural underpinnings of preschooler’s semantic processing: evidence from the N400 and theta frequency of the EEG
Authors: Poudel Sonali , Schneider Julie M. , Maguire Mandy
Published: February 2021

Semantic mastery requires knowing not only a word’s meaning but also how the word relates to other words in one’s lexicon. To better understand the neural correlates of young children’s semantic networks, we used EEG to examine the neural activity of pre-school aged children (3-5-year-olds) as they listened to noun pairs that were either semantically related (e.g., horse - sheep) or unrelated (e.g., garage - sheep). Like adults and children in previous studies, children in the current study exhibited a significantly larger N400 amplitude to semantically incongruent word pairs compared to semantically congruent word pairs. Surprisingly, children’s theta response was opposite of that previously reported in adults. Children exhibited greater theta power in response to semantically congruent word pairs as opposed to incongruent words pairs. Further, there was a significant positive correlation between the N400 and theta effects in children. These results provide novel insights into the neural underpinnings of semantic processing in children and emphasize the importance of investigating both theta and the N400 with respect to semantic development.
operasi uner
Authors: syam sartika
Published: February 2021

operasi uner adalah berupa operasi negasi
Um conjunto não mensurável
Authors: Lima Eduardo Dias
Published: February 2021

Uma das criações mais importantes da Análise do século XX foi a Integral de Lebesgue, que estendeu notavelmente a Integral de Riemann, resolveu em um período de poucos anos os problemas fundamentais da Teoria da Integração e deu um impulso relevante à Análise Funcional, à Teoria das Equações Diferenciais e Integrais e à Teoria da Probabilidade. O ponto básico dessa nova teoria foi a introdução da noção de medida. Medida, a grosso modo, é uma função cujo domínio é um conjunto de subconjuntos de R e cujo contradomínio é o conjunto dos números reais não negativos (unido com o símbolo +∞). O comprimentode um intervalo, por exemplo, é uma medida, digamos L, definida sobre todos os intervalos da reta real, tal que L(I) = b − a, onde a e b são os extremos do intervalo L e L(I) = +∞ se L for não limitado. Ora, a medida L está definida apenas para intervalos. Seria interessante estender esse conceito para outros subconjuntos da reta. Neste trabalho, será definida a medida exterior de um subconjunto de R e, com esta medida, será definida a noção de conjunto mensurável.
Sosyal ve Beşerî Bilimlerde Teori ve Araştırmalar
Authors: AISDL
Published: February 2021

Sosyal ve Beşerî Bilimlerde Teori ve Araştırmalar - Cilt 2Editör: Doç. Dr. Erdem Sarıkaya
SPRY2 is differentially expressed in both lymph node and brain metastases in human breast cancer.
Authors: Mamoor Shahan
Published: February 2021

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that sprouty homolog 2, encoded by SPRY2, was among the genes whose expression was most quantitatively different in the brain metastases of patients with metastatic breast cancer. SPRY2 mRNA was present at decreased quantities in brain metastatic tissues as compared to primary tumors of the breast. Importantly, expression of SPRY2 in primary tumors was significantly correlated with patient recurrence-free survival in patients with breast cancer. Modulation of SPRY2 expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain.