bluuebunny/crossref_metadata_2025 huggingface dataset:
The Working Alliance Inventory - Short Revised: Psychometric properties of the youth and therapist form in youth mental health and addiction care
Authors: Benthem Patty van , Lans Rikkert M. van der , Lamers Audri , Blanken Peter , Spijkerman Renske , Vermeiren Robert R.J.M. , Hendriks Vincent M.
Published: January 2023

The therapeutic alliance is considered to play an important role in youth treatment. The commonly used versions of the Working Alliance Inventory (WAI) are based on Bordin’s three-dimensional alliance model. However, previous psychometric studies of the WAI did not find this three-dimensional structure in youth psychotherapy. These earlier findings may indicate different perceptions of the alliance by adolescent versus adult patients, but may also be due to methodological shortcomings. The current study aims to address previous study limitations by evaluating the factor structure of the most recent and refined version of the WAI in youth treatment and using multilevel analysis to address the hierarchical structure of the alliance data. We examined the psychometric properties of the youth (n = 203) and therapist (n = 62) versions of the short revised WAI in youth mental health and addiction care and tested the three multilevel models of alliance at start of treatment and 2-month follow-up. Our results suggests a two-factor model for youth and a three-dimensional model for their therapist at both time points. Since this is the first study that finds a best fit for a two-dimensional construct of alliance in youth, more research is needed to rule out whether the differences in alliance dimensions are due to measurement differences between the WAI-SR for youth and therapists or whether youth and their therapists truly differ in their perceptions of the concept of alliance.
Anodal Cerebellar t-DCS Impacts Skill Learning and Transfer on a Robotic Surgery Training Task
Authors: Caccianiga Guido , Mooney Ronan A. , Celnik Pablo A. , Cantarero Gabriela L. , Brown Jeremy D.
Published: January 2023

The cerebellum has demonstrated a critical role during adaptation in motor learning. However, the extent to which it can contribute to the skill acquisition of complex real-world tasks remains unclear. One particularly challenging application in terms of motor activities is robotic surgery, which requires surgeons to complete complex multidimensional visuomotor tasks through a remotely operated robot. Given the need for high skill proficiency and the lack of haptic feedback, there is a pressing need for understanding and improving skill development. We investigated the effect of cerebellar transcranial direct current stimulation applied during the execution of a robotic surgery training task. Study participants received either real or sham stimulation while performing a needle driving task in a virtual (simulated) and a real-world (actual surgical robot) setting. We found that cerebellar stimulation significantly improved performance compared to sham stimulation at fast (more demanding) execution speeds in both virtual and real-world training settings. Furthermore, participants that received cerebellar stimulation more effectively transferred the skills they acquired during virtual training to the real world. Our findings underline the potential of non-invasive brain stimulation to enhance skill learning and transfer in real-world relevant tasks and, more broadly, its potential for improving complex motor learning.
Sex-dependent behavioral alterations in a poly(I:C)-induced maternal immune activation model without segment filamentous bacteria
Authors: Iwamoto Kazuya , Bundo Miki , Murata Yui , Imamura Yuko , Nakachi Yutaka , Fujii Shinya , Kato Tadafumi , Kubota-Sakashita Mie
Published: January 2023

Maternal immune activation is one of the major environmental risk factors for offspring to develop psychiatric disorders. A synthetic viral mimetic immunogen, polyinosinic-polycytidylic acid (poly(I:C)), has often been used to induce maternal immune activation in animal models of psychiatric disorders. In the mouse poly(I:C) model, the existence of segment filamentous bacteria (SFB) in the maternal intestine has been reported to be important for the induction of ASD-related behavioral alterations as well as atypical cortical development called cortical patches. This study aimed to elucidate the effect of poly(I:C) in the absence of intestinal SFB, which was maintained by vancomycin drinking. The poly(I:C) was administered at various time points between embryonic Day 9 to 16. In this condition, cortical patches were not observed at postnatal Day 0 or 1. The conspicuous PPI deficit of male adult offspring was observed in a poly(I:C) time-dependent manner, whereas the effect on females appeared less clear. On the other hand, a notable deficit in social interaction was observed in female mice, whereas males were less affected. This study revealed sex-dependent behavioral alterations in the mouse poly(I:C) model in the SFB-negative condition.
Explicit multi-slit Loewner flows and their geometry
Authors: Theodosiadis Eleftherios
Published: January 2023

In this paper we present explicit solutions to the radial and chordal Loewner PDE and we make an extensive study of their geometry. Specifically, we study multi-slit Loewner flows, driven by the time-dependent point masses $\mu_{t}:=\sum_{j=1}^{n}b_j \delta_{\{\zeta_j e^{iat}\}}$ in the radial case and $\nu_t:=\sum_{j=1}^{n}b_j\delta_{\{k_j\sqrt{1-t}\}}$ in the chordal case, where all the above parameters are chosen arbitrarily.
Furthermore, we investigate their close connection to the semigroup theory of holomorphic functions, which also allows us to map the chordal case to the radial one.
Prediction of water-level variations using a combined time series-geostatistical model in an aquifer surrounded by karstic formation: A case study from the semi-arid Hamadan province, Iran
Authors: Tizro A. Taheri , Fryar Alan E. , Voudouris K. S. , Talebi M. , fasihi rojin
Published: January 2023

Understanding groundwater responses to recharge is particularly important in alluvial aquifers which are surrounded by karstic formations in semi-arid and arid regions, such as the high Zagros region of western Iran. Evaluation of input and output time series provides comprehensive information on the hydrodynamic behavior of these aquifers. Time-series models were used to predict water levels using 20 years of monthly data (1997–2017) from 29 observation wells in the Nahavand Plain aquifer. Water levels were interpolated using conventional kriging and inverse-distance weighting and show consistent trends. Water-level change maps were prepared for annual intervals from 2012 to 2019 and for the period 2018–2022. Most of the area shows a trend of rising water levels, which appears to reflect recharge through karstic formations in the area.
Theoretical studies on Copper(II) complexes based on different carboxylate ligands: Hirshfeld surface analysis and molecular docking studies
Authors: Akhtar Muhammad Nadeem , Bilal Muhammad Safdar , Ali Arfan , Waseem Shazia , shahzad Muhammad Nadeem , Ibragimov Aziz B. , Rehman Aziz ur , Ahmad Muhammad Shahwaz , Shahid M.
Published: January 2023

Hirshfeld surface analysis and molecular docking study were carried out on a series of copper complexes formulated; [CuII2(C6H5COO)4(C6H5COOH)2], C6H5COOH = benzoic acid (1), [Cu(ppa)2(H2O)2]n, ppa = 3-Pyridinepropionic acid (2) and [Cu(N3)(C6H5COO)(MeOH)]n (3).
Hirshfeld surface investigation is explored for analysing molecular attractions and indicating all of the supramolecular communications of the crystal arrangement. The 2D graphs of 1 and 2 are identical, indicating the H∙∙∙H, O∙∙∙H/H∙∙∙O and C∙∙∙H/H∙∙∙C are the major participation of the crystal pattern of arrangement of these molecules, with the H∙∙∙H and O∙∙∙H/H∙∙∙O attachments contributing with 42.4 %, 41.6 % and 9.9 %, 8.9 % for 1 and 2 respectively. In 3, the 2D plot is decayed to show H∙∙∙H (33%), N∙∙∙H (13.5%) and O∙∙∙H/H∙∙∙O (5.9%), interactions specific region while C∙∙∙H/H∙∙∙C has 13 % of intermolecular interactions. Molecular docking studies in 1-3 indicates about the minimum relative interaction energies in these complexes are -6.2, -7.8 and -7.6 kcal/mol and these negative values suggest greater binding potentials of the complexes to DNA.
Corneal Endothelial cell changes after sub scleral Trabeculectomy in glaucoma patients
Authors: Hassan Hamida A. k. , Shalaby Sawsan Abdel Sabour , Mahmoud Doaa Aly
Published: January 2023

Background: About 1% of the population over the age of 40 develops glaucoma, making it the most common cause of irreversible blindness. Seventy-four per cent of all glaucoma cases are primary open-angle glaucoma. Trabeculectomy is a form of modern filtration surgery used to lower intraocular pressure in a glaucoma patient.
Aim of the Work: evaluation of corneal endothelial cells changes before and after sub scleral trabeculectomy using specular microscopy.
Patients and Methods: Our study was a prospective non-randomized study of 20 glaucomatous patients managed by trabeculectomy with Mitomycin C, the study included patients above the age of 40 years with open angle glaucoma that failed to be controlled by medical treatment. We compared the preoperative and postoperative central corneal endothelial cell density (ECD), endothelial cell coefficient of variation (CV), Hexagonal cell percentage, corneal thickness, best-corrected visual acuity, and intraocular pressure (IOP).
Results: our study revealed a highly significant decrease in central corneal endothelial cell count following trabeculectomy, the suggested mechanisms may be the toxic effect of MMC, increased manipulation in the anterior chamber during surgery and fluctuation of IOP following surgery
Conclusion: According to our findings, the central corneal thickness hardly budges after trabeculectomy, and the fraction of hexagonal cells decreases.
Tachyonic AdS/QCD, Determining the Strong Running Coupling and β-function in both UV and IR Regions of AdS Space
Authors: Issifu Adamu , Abbey Elijah A. , Brito Francisco A.
Published: January 2023

In this paper, we investigate QCD-like running coupling αsAdS (Q2) and its associated β-function β(Q2) in the spirit of tachyonic AdS/QCD. We distort the bulk AdS5 space using color dielectric function G(ϕ(z)) associated with tachyons, with ϕ(z) the tachyon field. The function presents different properties of αsAdS (Q2) at small and large values of the fifth-dimensional holographic variable z. The function distorts the AdS space, giving αsAdS (Q2) and its β-function β(Q2) at any Q2 scale, with Q2 the space-like momentum. The result obtained for a large value of z is expected to show characteristics similar to nonperturbative QCD. On the other hand, the result obtained for a small value of z is expected to show characteristics similar to perturbative QCQ. The presence of free tachyons leads to distortion of the AdS space at a small z, that notwithstanding, condensed tachyon states also lead to large z distortion. This provides a unified background for determining αsAdS (Q2) and its β(Q2) in both the ultraviolet (UV) and infrared (IR) regions using a single function in the framework of tachyonic AdS/QCD.
Intelligent Approach of Packet Drop Mitigation in Wireless Infrastructure- Less Networks due to system fault and Malicious Nature
Authors: P Venkat Reddy , Mohammad Arshad Ahmad Khan , G Prasanth Kumar , Gaddameddi Dinesh Kumar , Abualigah Laith
Published: January 2023

Wireless Infrastructure-Less Networks comprise of the features such as Adaptation and self-forming, due to which one can establish the network regardless of geographical location. The network aims to enable connectivity anywhere and any place. The network applications are Health care, military, and disaster recovery. The applications are sensitive, and secure communication is a challenging and vital issue, as one wrong message can affect the objective of the application. The routing process is responsible for computing the path and forwarding the information through the calculated route to enable communication in any network. However, network routing is challenging and vulnerable due to its peer-to-peer nature. One of the routing problems in the network is packet dropping, which could be due to selfishness, malicious nature, or system fault. Different mechanisms are designed to prevent packet drops in the network, but they could not differentiate whether the packet drops were due to malicious reasons or system faults. The Paper aims to design an intelligent mechanism to mitigate packet drops from the network by differentiating packet drops' causes. The proposed work validated with a network simulator, and results show that the proposed mechanism effectively prevents packets drop from the network.
A Feature Evolution Aware Classification Framework for Streaming Data using Dynamic Autoencoder and Ensembled Learning
Authors: KT Jafseer , S Shailesh , A Sreekumar
Published: January 2023

Recent advancements in the field of data mining and knowledge discovery have opened up a multitudeof research opportunities related to streaming data. One major challenge in handling streaming data isbuilding efficient machine-learning models that handle the dynamics of features and concepts. Focusing more on features, feature drift and evolving features are among the most unaddressed issues. It isdifficult to deal with the evolution of features in a stream; since most machine learning algorithms arerestricted to learning a fixed number of features. In the proposed work, a machine learning frameworkfor data streams with feature evolution is introduced. This methodology utilizes a dynamic autoen-coder to translate varying features into feature spaces with fixed dimensions. For classification, we constructed an ensemble model with Logical Regression, a Decision Tree, a Support Vector Machine,and K-Nearest Neighbor(KNN), which preserves past concepts. Based on experimental results, themodel was found to be promising for a variety of datasets, including Weather data (accuracy86%), Electricity data (94%), and Forest Cover types data (95%). By effectively combining deep-learning techniques with traditional approaches, many streaming data challenges can be addressed
Ligamentum teres hepatis wrapping of the gastroduodenal artery stump protection during pancreaticoduodenectomy: a single-center experience
Authors: Wu Xiang , Xu Xiao , Hu Xiaodong , Lu Jun , Fang Shenzhe , Wang Luoluo , Ruan Yi , Lu yeting , Yucheng Huang , Zhou Xinhua , Li Hong
Published: January 2023

Background
Stump hemorrhage of the gastroduodenal artery (GDA) is a major postoperative risk of pancreaticoduodenectomy (PD). We determined whether wrapping the GDA stump with the ligamentum teres hepatis (LTH) would reduce postoperative pancreaticoduodenal bleeding.
Methods
We retrospectively reviewed 148 patients who underwent PD at Li Huili Hospital of Ningbo Medical Center from November 2015 to September 2021. We compared perioperative data from 63 PD patients without wrapping of the GDA (the unwrapped group) and 85 whose GDA stump were wrapped (the wrapping group).
Results
There was no significant difference in the groups' baseline characteristics. The postoperative GDA stump bleeding incidence was significantly lower in the wrapped group than in the unwrapped group (7.9% vs. 0% p = 0.013). There was no significant difference in the incidence of other complications (e.g., intraabdominal infection, pancreatic fistula, biliary fistula, and gastrointestinal bleeding).
Conclusions
Using the LTH to wrap the GDA stump during PD can reduce the incidence of bleeding from the GDA stump but not the incidence of other complications.
Importance of derivatization in cholesterol analysis using GC-FID for bakery products containing plant and animal lipid
Authors: Islam Md. Atiqual , Hong Won-Ho , Chun Jiyeon
Published: January 2023

Cholesterol can be analyzed using derivatization and non-derivatization techniques. Analysis without derivation is a simple and reproducible method for some samples. However, cholesterol and α-tocopherol could be eluted together during gas chromatographic analysis if the sample contains both analytes. In this study, the importance of derivatization in cholesterol analysis in bakery products was investigated. Derivatized and non-derivatized cholesterol and α-tocopherol standards were eluted on HP-5 capillary column in GC-FID. The cholesterol and α-tocopherol standard resolution (Rs) using derivatization technique was 3.1 which is considered as well separated (> 1.5) based on AOAC guidelines. However, cholesterol and α-tocopherol were coeluted by GC-FID without derivatization. The GC-FID cholesterol analytical method was validated and applied for cholesterol determination in bakery samples. Method validation results were effective to be used for bakery products: limits of detection (0.03 mg/100 g) and quantification (0.08 mg/100 g), accuracy (102.1% recovery) and precision (repeatability: relative standard deviation (RSD) 1.5%; reproducibility: RSD 1.9%). The cholesterol content of bakery products range from 2.76 ± 0.06 mg/100 g (castella) to 114.26 ± 4.72 mg/100 g (chrysanthemum bread) depending on the ingredients used. This study shows that derivatization step is essential in cholesterol analysis of bakery products containing both cholesterol and α-tocopherol to prevent possible overestimation of cholesterol.
Differential renal expression of IFN-α and BAFF and its relevance to disease activity and treatment responsiveness in patients with proliferative lupus nephritis
Authors: Nawata Aya , Nakayamada Shingo , Hisano Satoshi , Miyazaki Yusuke , Miyamoto Tetsu , Shiba Eisuke , Hisaoka Masanori , Tanaka Yoshiya
Published: January 2023

Background
Molecularly targeted therapies are emerging for treating lupus nephritis (LN). This study aimed to assess the immunohistochemical findings of the cytokines in renal tissue and their pathological and clinical relevance in LN.
Methods
Fifty patients with proliferative LN (ISN/RPS class III and IV), five with LN class II, IgA nephropathy, and five with idiopathic hematuria as controls were enrolled. Immunohistochemistry (IHC) for CD3, CD20, interferon-alpha (IFNα), interleukin (IL)-12/p40, and B-cell activating factor (BAFF) was performed. The IHC score was calculated by scoring the number of positive cells/area of the cortex. Proliferative LN cases were grouped by the dominant expression of IFN-α, IL-12/p40, and BAFF, and subsequently, clinicopathological features were compared.
Results
Clinical data of patients with proliferative LN included urine protein creatinine ratio, 2.2 g/gCre; anti-ds-DNA antibody, 200.9 IU/mL; CH50, 21.9 U/mL; Systemic Lupus Erythematosus Disease Activity Index, 19.8 points. Proliferative LN cases, including class III (n = 18) and IV (n = 32), were classified into three subgroups according to the IHC score based on the dominancy of IFN-α (n = 17), IL-12 (n = 16), and BAFF group (n = 17) proteins. Hypocomplementemia and glomerular endocapillary hypercellularity were significantly increased in the IFN-α group, whereas chronic lesions were significantly higher in the IL-12 group (p < 0.05). The IFN-α group had a poorer renal prognosis in treatment response after 52 weeks.
Conclusions
The IHC of IFN-α, IL12, and BAFF for proliferative LN enabled grouping. Especially, the IFN-α and IL-12 groups showed different clinicopathological features and renal prognoses. The results indicated the possibility of stratifying cases according to the IHC of target molecules, which might lead to precision medicine.
Research on the stability and control technology of the surrounding rock in gob-side entry driving in an extrathick coal seam with varying thickness
Authors: Shan Renliang , Liu Shuai , Wang Hailong , Li Zhaolong , Huang Pengcheng , Dou Haoyu , Wu Jingtong
Published: January 2023

The deformation and failure characteristics and control methods of the surrounding rock of a roadway have always been the focus of attention when gob-side entry driving (GED) is performed in extrathick coal seams. In this paper, field investigation, theoretical calculations and numerical simulations are performed to analyse the distribution range of the limit equilibrium area in the coal seam near the gob (CSNG) before GED and the stability of the surrounding rock after GED for different coal seam thicknesses. The research results are as follows: (1) If a 5 m coal pillar is planned for GED, the limit equilibrium area will gradually expand with increasing coal seam thickness. When the coal seam thickness exceeds 18 m, the driving position will be completely in the limit equilibrium area. (2) After GED, with the increase in coal seam thickness, the bearing capacity of the roadway roof and two sides gradually decreases, and the range of the plastic zone gradually expands. The roadway deformation changes from local deformation to large deformation, and the coal seam side and roof corner are the most affected areas. Based on these results and a new support technology called anchor cable with c-shaped tube (ACC), the surrounding rock control strategy and full-section ACC support scheme are proposed. The bidirectional control of the surrounding rock (in the axial and tangential directions) in the gob-side roadway of the extrathick coal seam is realized, as verified by numerical simulation and field application data.
A nomogram based on radiomics to predict microvascular invasion and overall survival in intrahepatic cholangiocarcinoma
Authors: Miao Geng yun , Qian Xian ling , Zhang Yun fei , Wu Fei , Huang Peng , Wang Fang , Zhou Chang wu , Lu Xin , Yang Chun , Zeng Meng su
Published: January 2023

Background: Intrahepatic cholangiocarcinoma (ICC) is aggressive and ranks second among primary liver cancer. Microvascular invasion (MVI) is a predictor of poor prognosis in ICC, and preoperative prediction of MVI status can facilitate personalized therapeutic regime.
Purpose: To establish a comprehensive model based on MR radiomics for MVI status stratification and overall survival prediction in ICC patients preoperatively.
Methods: 249 ICC patients were randomized into training and validation cohort (174:75) and a time-independent test cohort with 47 ICC patients were enrolled. Independent clinical and imaging predictors were identified by univariate and multivariate logistic regression analysis. The radiomic model was based on the robust radiomic features extracted by logistic regression classifier and the least absolute shrinkage and selection operator algorithm. The imaging-radiomics (IR) model integrates the independent predictors and robust radiomics features. The predictive efficacy of models is evaluated by receiver operating characteristic curve, calibration curve and decision curve. Multivariate Cox analysis identified the independent risk factors of overall survival, Kaplan-Meier curves were plotted and nomogram visualized the predictive model.
Results: Imaging model comprises tumor size and intrahepatic duct dilatation, radiomics model comprises 25 stable radiomics features. The IR model shows desirable performance (AUCtraining= 0.890, AUCvalidation= 0.885 and AUCtest= 0.815). The calibration curve and decision curve validate the clinical utility. Overall survival predicted by histological and IR model-predicted MVI groups exhibit similar predictive efficacy.
Conclusion: IR model and nomogram based on IR model-predicted MVI status may be a potential tool in MVI status stratification and overall survival prediction of ICC patients preoperatively.
The cytotoxic and apoptotic effects of Thymus vulgaris extracts on human breast cancer cell lines
Authors: Çelikok Yasin , Şener Leyla Türker , Bütün Burcu , Albeniz’s Işıl
Published: January 2023

The authors have requested that this preprint be removed from Research Square.
Nodakenin ameliorated TNBS-induced experimental colitis in mice by inhibiting intestinal epithelial cell pyroptosis
Authors: Geng Zhijun , Li Jing , Huang Ju , Zhao Tianhao , Wang Xinru , Bao Yunxi , Ding Yingao , Deng Min , Wang Yueyue , Song Xue , Zhang Xiaofeng , Wang Lian , Zuo Lugen , Hu Jianguo
Published: January 2023

Background and Aims Pyroptosis of intestinal epithelial cells is associated with intestinal barrier dysfunction and the intestinal inflammatory symptoms of Crohn's disease (CD). The natural plant monomer, nodakenin (Nod), inhibits NOD-like receptor protein 3 (NLRP3) expression, and this study aimed to evaluate its effect on CD-like colitis, as well as possible mechanisms. Methods Using TNBS intervention mice as CD animal models, the therapeutic effect of Nod on CD-like colitis in mice was explored through disease activity index (DAI) analysis, weight change, histological analysis, inflammatory factor expression and intestinal barrier function. In addition, the direct effect of Nod on the pyroptosis of intestinal epithelial cells was explored by immunofluorescence and western blot detection in LPS-/ATP-induced colon organoid models. Furthermore, through bioinformatics and in vivo and in vitro experimental verification, the potential mechanism by which Nod protects intestinal epithelial cells was explored. Results Nod intervention improved colitis and intestinal barrier function in TNBS-induced mice, as demonstrated by improvements in weight loss, DAI, tissue inflammation score, proinflammatory factor expression, and intestinal permeability. In addition, Nod inhibited the pyroptosis of intestinal epithelial cells in colitis mice and LPS-/ATP-induced colon organoids, as well as the expression of key pyroptosis regulators, such as NLRP3, GSDMD-N, and cleaved-caspase-1. Mechanistically, Nod inhibited the activation of PI3K/Akt signalling a in intestinal epithelial cells in TNBS-induced mice and LPS-/ATP-induced colonic organoids. Conclusions Nod restrained the pyroptosis of intestinal epithelial cells to protect the intestinal barrier of CD-like colitis by inhibiting PI3K/Akt signalling, this may provide a new option for the treatment of Crohn's disease.
Allocation of virtual machine in a cloud environment based on machine learning
Authors: kamoun-abid Ferdaous , Frikha Hounaida , Meddeb-Makhoulf Amel , Zarai Faouzi
Published: January 2023

Nowadays, the technics of health applications that use the cloud are being developed. However, the existing methods are static and cannot approve dynamic changes in the dynamic environment (for example, when the network and virtual machines (VMs) have a change in resources values) during the execution process. Since the cloud environment provides virtualized resources for computing and for storage (for example: health information) with used many virtual machines. Also, data applications require communication between these virtual nodes, placement of VMs and data location to achieve overall computation time. The majority of scientific researchers present in the current literature that the selection of physical nodes to place data and virtual machines as not separate problems. In addition, in the cloud environment, the major challenge is network security. So, there is no better solution than firewalls which are used to filter packets (detect spam packets). But the problem is that the cloud has a dynamic topology, for that these firewalls cannot examine the content from inside the packet and the network becomes vulnerable. This traditional firewall they only provide basic protection at the network layers and cannot work in complex topologies like Cloud Computing. For this, the risk that we will have unprotected areas. Regarding this challenge, in this article, we proposed to divide the cloud topology into zones, so that each zone is supervised by a controller. Thus, each virtual machine is supervised by a firewall. For remote network saturation with exchanged data between controllers and VMs, the number of controllers must be minimized and the addition of a new VM must be well placed in our new architecture (Divided-Cloud). For this, in this work, we used a learning method of Machine Learning (ML) "Decision Tree" at the level of the addition of a new controller. According to the affected result, the algorithm reaches its maximum accuracy which is equal to 83%. Furthermore, about the location of a new VM, we used a “KNeighborsClassifier” calcification method and it gives an accuracy is equal to 83%.
Impact of rater experience on detecting MRI features of idiopathic intracranial hypertension
Authors: Bsteh Gabriel , Marik Wolfgang , Macher Stefan , Schmidbauer Victor , Krajnc Nik , Pruckner Philip , Mitsch Christoph , Novak Klaus , Wöber Christian , Pemp Berthold
Published: January 2023

Background: In idiopathic intracranial hypertension (IIH), certain MRI features are promising diagnostic markers, but impact of neuroradiologist’s experience and specific referral question on identifying these features correctly is unknown. Therefore, we compared ratings in real-world setting by radiologists with unknown awareness of IIH-MRI-features, with the ratings of a junior neuroradiologist aware of features but without special IIH training, and a senior neuroradiologist with experience in IIH imaging (gold standard).
Methods: For comparing the 3 settings, we included patients from the Vienna-Idiopathic-Intracranial-Hypertension (VIIH) database with definitive IIH according to Friedman criteria and routine cranial MRI performed during diagnostic work-up and assessed frequencies of empty sella (ES), optic nerve sheath distension (ONSD), optic nerve tortuosity (ONT), posterior globe flattening (PGF) and transverse sinus stenosis (TSS).
Results: We evaluated MRI scans of 84 IIH patients (88% female, mean age 33.5 years). By gold standard, 78.6% had ≥1 IIH-MRI-feature and 60.0% had ≥3 features with ONSD most frequent (64.3%) followed by TSS (60.0%), ONT (46.4%), ES (44.4%) and PGF (23.8%). Compared to gold standard, IIH features were described significantly less frequently in routine MRI reports (≥1 feature 64.3%, ≥3 features 15.7%, ONSD 28.6%, ONT 13.1%, PGF 4.8%, TSS 42.9%, p<0.01 respectively) except for ES (42.9%, p=0.9). Specific referral question regarding IIH increased detection rates in routine reports, but rates of ONSD, ONT and PGF were still significantly lower than by gold standard.
Contrary, rating by a neuroradiologist without special training produced significantly higher frequencies of ≥1 / ≥3 MRI features (95.2% and 72.5%, p<0.01 respectively), ONSD (81.0%, p<0.01) and ONT (60.7%, p<0.01), but not ES (47.6%), PGF (29.8%) and TSS (68.1%).
Conclusions: IIH-MRI-features are underestimated in routine MRI reports and partly overcalled by less experienced neuroradiologists, driven by features less well known or methodologically difficile. Reevaluation of MRI scans by an experienced rater (and to a lesser degree specific referral question) improves diagnostic accuracy.
Etiology and Prevention of Recurrent Cystitis Based on Vaginal Microbiota: A Retrospective Cohort Study
Authors: Sekito Takanori , Wada Koichiro , Ishii Ayano , Iwata Takehiro , Matsubara Takehiro , Tomida Shuta , Watanabe Masami , Araki Motoo , Sadahira Takuya
Published: January 2023

Background: The etiology of recurrent cystitis from vaginal microbiota and importance of vaginal Lactobacilluswere determined.
Materials and Methods: Vaginal samples were obtained from postmenopausal women and classified into four groups: healthy controls; uncomplicated cystitis; recurrent cystitis; and recurrent cystitis prevented by Lactobacillus crispatus-containing vaginal suppositories (prevention). Principal coordinate analysis was used to analyze 16S rRNA gene sequencing data from the vaginal microbiome.
Results: Among 129 vaginal samples from 39 women, the vaginal bacterial communities were divided into three clusters (A, B, and C) using cluster analysis. The top six taxa were as follows: Prevotella, Lactobacillus, Streptococcus, Enterobacteriaceae, Anaerococcus,and Bifidobacterium. Fourteen of 14 (100%) samples from the recurrent cystitis and 51 of 53 (96%) samples from the prevention groups were in clusters B and C, respectively, while 29 of 38 (76%) samples from the healthy and 14 of 24 (58%) samples from the uncomplicated cystitis groups were in cluster A. The principal coordinate analysis plots in the uncomplicated cystitis group were similar to the healthy group, indicating a large separation between the recurrent cystitis group and the uncomplicated cystitis group. Among patients with recurrent cystitis, Lactobacillus was undetectable before administration of Lactobacillus crispatus-containing vaginal suppositories, while the median relative abundance of Lactobacillus was 19% during administration of Lactobacillus crispatus-containing vaginal suppositories (p=0.0211), reducing the average cystitis episodes per year (6.3 vs. 2.4, p=0.0015).
Conclusions: The vaginal microbiota of postmenopausal women with recurrent cystitis and uncomplicated cystitis differed. Vaginal administration of Lactobacillus prevented recurrent cystitis by stabilizing vaginal dysbiosis and causing a loss of pathogenic bacteria virulence.
Beiträge zur Fortschreibung der Florenliste Deutschlands (Pteridophyta, Spermatophyta) – Neunte Folge
Authors: Hand Ralf , Buttler Peter
Published: January 2023

In dem Beitrag sind weitere Nachträge und Korrekturen zur 2008 veröffentlichten "Liste der Gefäßpflanzen Deutschlands" zusammengestellt und kommentiert. 16 Taxa müssen der Liste hinzugefügt werden, 1 Taxon muss gestrichen werden. Eingeschlossen sind Neukombinationen von Michael Hohla in Elymus und Peter Wolff in Dactylorhiza.
Hieracium diaphanoides subsp. chaucorum Gottschl. & Schabelr., eine neue Hieracium-Unterart aus dem nordwestdeutschen Tiefland
Authors: Schabelreiter Dennis , Gottschlich Günter
Published: January 2023

Als Ergebnis taxonomischer Überprüfungen von Hieracium-murorum-Vorkommen im nordwestdeutschen Tiefland wird eine bisher unbekannte Unterart von H. diaphanoides beschrieben und abgebildet.
Chromosomenzahlen von Farn- und Samenpflanzen aus Deutschland 11
Authors: Gregor Thomas , Paule Juraj
Published: January 2023

Angegeben wird jeweils das Sammeldatum des für die Chromosomenzählung verwendeten Materials (Lebendpflanze, Samen) zuzüglich eines eventuell gesammelten Beleges sowie – getrennt durch einen Schrägstrich – Sammeldatum und Aufbewahrungsort eines Beleges der gezählten Pflanze.
Katalog der auf Herbarbelegen gebräuchlichen Abkürzungen Catalogus Abbreviationum in Schedis Herbariorum usitatorum
Authors: Schröder Christof Nikolaus
Published: January 2023

Beim Bearbeiten historischer Herbarbestände ist man mit zahlreichen Abkürzungen auf handgeschriebenen Scheden und gedruckten Etiketten konfrontiert, deren Auflösung nicht selten große Mühe bereitet. Es wird in die Besonderheiten historischer Abkürzungen, Datumsangaben und die Verwendung Römischer Zahlen eingeführt. Ein ausführlicher Katalog listet Abkürzungen und deren Auflösung sowie Übersetzung auf, die im Rahmen des von der GEFD geförderten Projektes "Virtuelles Herbarium Bochkoltz" und bei der Bearbeitung weiterer historischer Herbarbestände gesammelt wurden.
Schriftenschau
Authors: Caspari Steffen , Garve Eckhard , Frank Dieter , Meierott Lenz , Schön Michael , Gottschlich Günter , Meyer Norbert , Manitz Hermann
Published: January 2023

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Scrophularia neesii und Scrophularia umbrosa in Deutschland – ähnliche Ökologie, aber unterschiedliche Verbreitung zweier Sippen eines Autopolyploidie-Komplexes
Authors: Gregor Thomas , Dillenberger Markus S. , Schmidt Marco , Hand Ralf , Abdank Anja , Böcker Reinhard , Ciongwa Peter , Diewald Wolfgang , Dunkel Franz G. , Ehmke Wolfgang , Finus Paul , Frank Dieter , Hammel Steffen , Hofstetter Alexander , Hohla Michael , Horst Eggert , John Heino , Klotz Jürgen , Korsch Marion , Mause René , Meierott Lenz , Müller Frank , Möbius Friederike , Peintinger Markus , Reichert Hans , Ringel Heike , Schneider Rudi , Schröder Christof Nikolaus , Timmermann-Trosiener Irene , Mutz Sabine
Published: January 2023

Scrophularia neesii und S. umbrosa ließen sich durch relative Messung des DNA-Gewichtes mit Durchflusszytometrie sicher unterscheiden. Hybriden wurden nicht gefunden. S. neesii ist die weiter verbreitete Sippe mit einem Vorkommensschwerpunkt in Süddeutschland sowie in Teilen Westdeutschlands, S. umbrosa ist dagegen in Norddeutschland die häufigere Sippe. Nach unseren Daten ergibt sich eine leichte ökologische Differenzierung zwischen beiden Sippen: S. neesii besiedelt eher Gebiete mit niedrigeren Temperaturen und höheren Niederschlägen. S. umbrosa kommt signifikant häufiger an Flüssen vor, wogegen S. neesii deutlich häufiger Gräben und Bäche besiedelt. Beide Arten wachsen bevorzugt an Ufern von Fließgewässern, Funde an Stillgewässern sind selten. Die phylogenetische Verwandtschaft von S. neesii und S. umbrosa sowie der Ursprung von S. neesii wurden mit Hilfe von zwei DNA-Markern (Kerngenom: ITS – Genotyp; Plastidengenom: trnQ-rps16 – Haplotyp) an sechs Pflanzen von S. neesii, fünf Pflanzen von S. umbrosa und zwei Pflanzen von S. auriculata untersucht. Die Frage, ob S. neesii autopolyploid aus S. umbrosa hervorgegangen ist oder hybridogen aus S. umbrosa und S. auriculata, lässt sich danach zwar nicht absolut sicher beantworten, jedoch zeigen beide Marker eine nahe Verwandtschaft von S. neesii zu allen Proben von S. umbrosa. Dies macht eine autopolyploide Entstehung aus S. umbrosa wahrscheinlich.
Beiträge zur Fortschreibung der Florenliste Deutschlands (Pteridophyta, Spermatophyta) – Vierzehnte Folge
Authors: Hand Ralf
Published: January 2023

Weitere Nachträge und Korrekturen zur Liste der in Deutschland vorkommenden Gefäßpflanzen werden zusammengestellt und kommentiert. Für Deutschland neu sind 17 Taxa. Die Namen Geranium robertianum subsp. maritimum und Thalictrum minus subsp. saxatile werden im Hinblick auf die Änderung der Autorenschaft diskutiert.
Stipa pulcherrima subsp. palatina, eine neue Federgras-Sippe aus der Pfalz
Authors: Korneck Dieter , Scholz Hildemar
Published: January 2023

Von Leistadt in der Pfalz, dort an Kalkfelsklippen im Xerobrometum erecti, wird Stipa pulcherrima subsp. palatina H. Scholz & Korneck, subsp. nova, beschrieben. S. pulcherrima subsp. palatina unterscheidet sich von subsp. pulcherrima durch kürzere Deckspelzen (19–22 mm) mit abweichender Behaarung, da die Haarreihe auf dem Mittelnerv kürzer ist als die benachbarten. Die Pflanzen sind von weniger kräftigem Wuchs als bei subsp. pulcherrima. Wir betrachten S. pulcherrima subsp. palatina als einen Lokalendemiten der deutschen Flora.
Zwergformen bei Brombeeren (Rubus L. subgen. Rubus)
Authors: Weber Heinrich E.
Published: January 2023

Der Beitrag behandelt die in Europa nachgewiesenen Zwergformen der Gattung Rubus L. Sechzehn Arten (alle nur Sekt. Rubus) bilden solche offensichtlich genetisch fixierten Abwandlungen aus, die als Varietäten der betreffenden Arten eingestuft werden. Neu beschrieben werden R. marssonianus H. E. Weber var. pusillus H. E. Weber, R. muenteri T. Marss. var. pusillus H. E. Weber und R. senticosus Köhler ex Weihe var. pusillus H. E. Weber & Kiesewetter. Einen status novus erhalten R. gracilis J. & C. Presl var. parvulus (Hülsen) H. E. Weber, R. pyramidalis Kalt. var. parvifolius (K. Frid. & Gelert) H. E. Weber und R. silvaticus Weihe & Nees var. microphyllus (K. Frid. ex Erichsen) H. E. Weber. – Zwergformen sind meist etwa nur halb so groß wie die Normalform und weisen weitere charakteristische Merkmale auf. Ihre Häufigkeit nimmt von Norden nach Süden ab. Die meisten Zwergformen wachsen in Dänemark (13), es folgen Norddeutschland (9) und Mitteleuropa bis zur Donau (4). Weiter südlich und in Südeuropa fehlen sie. Von den Britischen Inseln sind vier Zwergformen bekannt.
Galium lucidum – kein sicherer Nachweis in Deutschland
Authors: Hügin Gerold
Published: January 2023

Das einzige aktuelle Vorkommen von Galium lucidum in Deutschland (Baden-Württemberg) hat sich als G. album herausgestellt. Die wenigen historischen Angaben sind zweifelhaft und können, solange keine Belege vorliegen, nicht als Nachweis gelten.
Taxonomische und nomenklatorische Neuigkeiten zur Flora Deutschlands 3
Authors: Hand Ralf , Buttler Karl Peter
Published: January 2023

Die Intention der hiermit fortgesetzten Reihe sowie die Kriterien zur Aufnahme der besprochenen Literatur und der nomenklatorischen Neuigkeiten sind in der Einführung zur ersten Folge in Kochia 1 erläutert.
Pteris cretica und Adiantum raddianum (Pteridophyta) in Licht- und Brunnenschächten im Ruhrgebiet – breiten sich subtropische Farnarten in Deutschland aus?
Authors: Keil Peter , Sarazin Andreas , Fuchs Renate , Riedel Christian
Published: January 2023

Im Rahmen stadtfloristischer Untersuchungen des Ruhrgebietes wurden in Brunnen- und Kellerlichtschächten Vorkommen von Pteris cretica var. albolineata (Pteridaceae) und Adiantum raddianum (Adiantaceae) nachgewiesen, beide taxonomisch im weiteren Sinne zu verstehen. Die Wuchsorte, Populationsgrößen und Begleitvegetation werden beschrieben, Status und Ausbreitungstendenzen der Taxa diskutiert.
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Authors: Nauenburg Johannes D. , Gregor Thomas , Zahlheimer Willy A. , Hand Ralf , Ottich Indra , Matzke-Haje Günter , Gottschlich Günter
Published: January 2023

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Quantitative Merkmale mitteleuropäischer Wildrosen (Rosaceae: Rosa) und ihre Eignung als Bestimmungsmerkmale
Authors: Reichert Hans
Published: January 2023

An einem Beispiel wird demonstriert, dass es oft vom Erfassungsaufwand abhängt, ob ein Merkmal als qualitativ oder quantitativ (zähl- bzw. messbar) einzustufen ist. Es folgt ein Überblick über quantitative Merkmale, die von 1820 bis heute in der Literatur über mitteleuropäische Wildrosenarten (Rosaceae: Rosa) behandelt werden. Bei vielen dieser Merkmale erscheint eine Erfassung in Ordinalskalen sinnvoller als eine metrische. Zu 8 Merkmalen, bei denen das Sammeln von Messwerten und ihre statistische Aufbereitung Erfolg verheißt, werden eigene Beobachtungen und Untersuchungen mitgeteilt. Bei ihrer Erfassung gilt es, eine Reihe von Fehlerquellen zu beachten, die meist in den Objekten, in einem Fall im Beobachter liegen. Bei der Erfassung von Hagebuttenmerkmalen muss ein Dimorphismus zwischen End- und Seitenblüten der Blütenstände berücksichtigt werden. Die Beschränkung von Messungen auf solitäre Blüten verringert die Streuung der Messwerte ebenso wie die Ermittlung der Standardabweichung anstelle der von älteren Autoren verwendeten Variationsbreite. Aufgrund einer optischen Täuschung wird die relative Länge des Fruchtstiels in Bezug zur Hagebuttenlänge meist zu hoch eingeschätzt. Merkmale, deren quantitative Erfassung diagnostisch brauchbare Daten liefern kann, sind in erster Linie die relative Fruchtstiellänge und der Griffelkanaldurchmesser, in zweiter Linie die Endfiederlänge, der Längen-Breiten Index der Endfiedern und die Kronblattlänge.
Schriftenschau
Authors: Hodvina Sylvain , Engelhardt Martin , Zündorf Hans-Joachim , Hohla Michael , Garve Eckhard , Gregor Thomas , Brandes Dietmar , Böhling Niels , Sukopp Herbert , Sukopp Ulrich , Meyer Norbert , Hand Ralf
Published: January 2023

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Gattung Alchemilla im Französischen und Schweizer Jura
Authors: Hügin Gerold , Fröhner Sigurd Erich
Published: January 2023

Alchemilla pseudodecumbens wird als Art neu beschrieben. Im Gegensatz zur weit verbreiteten A. decumbens bleibt ihr Areal auf den Jura beschränkt. In Abbildungen, Merkmals- und Bestimmungstabellen wird A. pseu­dodecumbens mit ähnlichen Arten verglichen (A. decumbens, A. demissa, A. frigens, A. lunaria, A. semisecta, A. subcrenata, A. undulata, A. versipila).
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Authors: Raus Thomas , Gregor Thomas , Korsch Heiko , Hand Ralf , Hohla Michael , Prasse Rüdiger , Böhling Niels
Published: January 2023

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Asplenium ×bosco-gurinense, hybr. nov., eine neue Streifenfarn-Hybride aus dem Tessin (Aspleniaceae, Pteridophyta)
Authors: Jessen Stefan , Bujnoch Walter
Published: January 2023

Eine Hybride zwischen Asplenium septentrionale (L.) Hoffm. subsp. septentrionale und A. viride (L.) Huds. wird beschrieben. Der Bastard wurde in einem Exemplar bei Bosco-Gurin im Schweizer Kanton Tessin gefunden. Die morphologische Mittelstellung sowie Sporen-, cytologische und molekulargenetische Untersuchungen bestätigten die vermutete Abstammung.
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Authors: Vanberg Christoph , Poppendieck Hans-Helmut , Gregor Thomas , Hand Ralf , Manitz Hermann , Bujnoch Walter , Kalheber Heinz
Published: January 2023

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Chromosomenzahlen von Farn- und Samenpflanzen aus Deutschland 8
Authors: Gregor Thomas , Hand Ralf
Published: January 2023

Angegeben wird jeweils das Sammeldatum des für die Chromosomenzahlung verwendeten Materials (Lebendpflanze, Samen) zuzüglich eines eventuell gesammelten Beleges sowie – getrennt durch einen Schrägstrich – Sammeldatum und Aufbewahrungsort eines Beleges der gezählten Pflanze. Wird nur ein Datum angegeben, ist allein die Wildaufsammlung dokumentiert.
Beiträge zur Fortschreibung der Florenliste Deutschlands (Pteridophyta, Spermatophyta) – Siebte Folge
Authors: Hand Ralf , Buttler Karl Peter
Published: January 2023

In dem Beitrag sind weitere Nachträge und Korrekturen zur 2008 veröffentlichten "Liste der Gefäßpflanzen Deutschlands" zusammengestellt und kommentiert. Beginnend mit der diesjährigen Folge werden die "Taxonomischen und nomenklatorischen Neuigkeiten zur Flora Deutschlands" in die Reihe integriert. 14 Taxa, darunter 4 eingebürgerte Neophyten, müssen der Liste hinzugefügt, 3 Taxa müssen gestrichen werden. Epilobium ciliatum subsp. adenocaulon und Hieracium austrobavaricum werden neu kombiniert, Euphrasia rostkoviana wird typisiert.
Book Review on Frank N. Pieke and Koichi Iwabuchi (2021). Global East Asia: Into the Twenty-First Century
Authors: Gentle Paul F.
Published: January 2023

Global trade is world-wide. This book focuses on East. The main countries examine China, Japan, Korea and Southeast Asia. The diasporas of some Eats Asian counties are examined in this book. Many different authors are considered in this book. A scholar East Asia and commerce may find this book to be helpful.