bluuebunny/crossref_metadata_2025 huggingface dataset:
Less Than One Millimeter Under the Great Toe is Enough to Change Balance Ability in Elite Women Handball Players
Authors: Viseux Frederic , Barbier Franck , Parreira Rodolfo , Lemaire Antoine , Villeneuve Philippe , Leteneur Sebastien
Published: October 2019

Team handball is a complex intermittent sport game, which requires several motor abilities and effective postural control. Objective evaluation of stabilometric variables may be interesting to assess and improve functional parameters by postural control management. The purpose of the study was to evaluate the effects of a small additional thickness placed under the great toe (TUGT) on the Centre of Pressure (CoP) parameters in elite women handball players. Fourteen elite women handball players voluntarily participated in this study. Two conditions were compared: TUGT 0 (control) and TUGT 0.8 mm; four variables were computed from the CoP displacements. A paired T‐test was performed for each variable. This study concludes that a low focal additional thickness placed under both great toes has an effect on the CoP measures used to assess postural control during an unperturbed stance. These results suggest that a low TUGT could contribute to a change in balance ability, and may be of clinical interest. This brings new perspectives in the management of athletes to prevent injury risk and optimize performance.
LncRNA PVT1 promotes proliferation and invasion through enhancing Smad3 expression by sponging miR-140-5p in cervical cancer
Authors: Chang Qing-Qing , Chen Chun-Yan , Chen Zhao , Chang Shuai
Published: October 2019

Background

Cervical cancer is one of the most frequent malignancies among females worldwide. Increasing evidence have indicated the participation of long noncoding RNAs (lncRNAs) in the progression and metastasis of cervical cancer. Our present study was conducted to explore the effects of lncRNA plasmacytoma variant translocation 1 (PVT1) on the progression of cervical cancer and the underlying mechanisms.

Materials and methods

Expressions of PVT1, miR-140-5p and Smad3 in cervical cancer cell lines were detected by qRT-PCR and western blotting. Bioinformatics analysis and luciferase assays were used to elucidate the potential correlations between PVT1, miR-140-5p and Smad3. The roles of PVT1 on the progression of cervical cancer cells were determined by transfecting sh-RNA through series function assays such as colony formation assay, wound healing assay, transwell assay.

Results

PVT1 and Smad3 were upregulated, and miR-140-5p was downregulated in cervical cancer cells. PVT1 could bind directly with miR-140-5p, and Smad3 was a downstream target of miR-140-5p. Inhibition of PVT1 could enhance expression of miR-140-5p, inhibit the expression of Smad3, significantly inhibited the proliferation, migration, invasion in cervical cancer cells. While transfection of miR-140-5p inhibitor could partially reverse the above changes in cervical cancer cells.

Conclusions

The results revealed that PVT1 could promote the proliferation and metastasis via increasing the Smad3 expression by sponging miR-140-5p, which might be a promising prognostic and therapeutic target for cervical cancer.
Strengthening Federalism Through Charter Decisions
Authors: Randall Brent
Published: October 2019

The Constitution Act, 1982, containing the Charter of Rights and Freedoms, is seen by many to be a major victory for individual liberty. The Charter is seen as a ground-breaking provision, but it is also at the mercy of interpretation. Like the Constitution containing it, there are many ambiguous terms which inevitably demand application when settling disputes between two parties. This requirement of interpretation can turn the Charter from celebrated to controversial depending on the interests involved. In Canada, provincial and federal legislatures are most often in charge of interpreting the Constitution favourably by creating laws that capture the spirit of the document. If for some reason there is concern with how the Constitution, and Charter, is interpreted through this legislation, the Supreme Court of Canada is the final decision-maker on its validity. This judicial review is the source of much debate, for a couple reasons. First, some take exception to the Supreme Court having the final say on rights issues. Second, when it is applied in such a way [...]
Open federalism: Harper’s proposal for Canadian federalism
Authors: Harmes Andrew
Published: October 2019

In order to try and address certain pressing issues in contemporary Canadian politics, the Harper government has devel-oped the concept of open federalism aimed at protecting areas of provincial jurisdiction from federal influence. Although this system of federalism is not entirely new in Canadian politics, it would be a change in the current relationship between the federal and provin-cial levels of government. While the concept of open federalism does make an intriguing argument to address certain issues in contem-porary Canadian politics, especially concerning Quebec, it does not necessarily address issues in most other provinces or work to strengthen national unity outside of Quebec [...]
Balancing Power: The Supreme Court of Canada’s Impartial Role in Federalism
Authors: Drury Darcy
Published: October 2019

The problem with Lord Acton’s state-ment is that it leaves out the third essential ingredient to a federal system of government: a supreme court. In Canada, like most federa-tions, the Supreme Court (SC) is responsible for articulating the constitution and serving as an independent mediator in intergovernmen-tal relations. Each decision made by the SC in regards to government jurisdiction changes the dynamics of Canadian federalism, and some critics fear it can be used as a centraliz-ing device by the federal government. This paper will discuss the nature of the SC by demonstrating its necessity, purpose, and the importance of its independence by examining its crucial role in Canadian federalism. Next, there will be a historical breakdown of the impact of2 the SC on the federal balance of powers through an examination of three es-sential eras: Judicial Committee of the Privy Council (decentralizing), Laskin (centralizing), and Charter (mixed), with analysis involving the attitudinal and legal theorist models of decision making in SC decisions. Finally, the SC’s impartiality towards provincial and feder-al preferences will be evaluated to show that justices have remained immune to direct po-litical pressures [...]
Canadian Federal Spending Powers: The Impact on Health Care Delivery
Authors: Nguyen Julie
Published: October 2019

National public health care has increasingly become a politically contentious concern for Canadian citizens since its establishment. The role ofCanadian federalism and intergovernmental relations has been a major contributor to the controversy surrounding the funding, the development, and the outcome of health care policy. While federalism has been attributed to the expansion of health care inCanada, it has also been criticized for lacking efficiency and harbouring intergovernmental power struggles. Although the Constitution Act of 1867 outlines that provinces are responsible for health care in their jurisdiction, in practice there is actually an unclear division of powers between the two levels of government (Maioni 2002). Health care is an industry that is constantly transforming, but the framework of Canadian federalism is not proficient enough to keep up with these much needed changes. As a result, citizens may not be receiving the best health care available, andare caught in the tug of war between the provinces and the federal government.[...]
The Call for Senate Reform: An Implausible Demand
Authors: Chandler Melissa
Published: October 2019

From shortly before Confederation in 1871, to the present day, the western population of Canada has felt isolated. The western Canadians feel as though the power holders in Ottawa have too much control. A phenomenon which has led to this feeling of alienation is an Upper House staffed with federal government appointees. When constitutional negotiations were occurring in 1980, the premiers and Prime Minister were discussing what kind of changes should be made to the Constitution. At the time, the premier of Alberta brought up what is now one of, if not the, major issue in the West: Senate reform. This issue has led the West to view Ottawa as having too much power. Furthermore, it has led to the feeling of alienation. This paper will discuss why Senate reform is desirable, but not possible.[...]
Canada’s Constitutional Monarchy
Authors: Reichert Veronika
Published: October 2019

Anytime a royal makes an appearance at an event, great public interest in royalty is generated, and with that the monarchy as an institution is brought to the attention of Canadians and the Commonwealth. There is a popular opinion that the monarchy no longer plays, and should no longer play, an important role in contemporary Canada, and with that a view that the monarchy is a useless appropriation of tradition, or even a harmful symbol of oppression, the latter view taken by Marc Chevrier who writes that “the Canadian neomonarchy feeds illusions of false grandeur that have no meaning in America and distract the people from thinking that they can be sovereign.”1 [...]
A Gay Federation: The Effects of Federalism on the Lesbian and Gay Movement in Canada
Authors: Keegan-Henry Morag
Published: October 2019

Alan Cairns argues that “federalism is not enough” to deal with non-territorial minorities.1 This certainly seems to have been the case with the Canadian LGBT (lesbian, gay, bisexual, and transgender)2 movement. In some ways, federalism (the specific system of sovereignty-sharing wherein both levels of government are co-equal and each is sovereign in areas under its jurisdiction) has directly inhibited attempts to stop discrimination, provide benefits to common-law same-sex partners, and legalize same-sex marriage. First, prior to the introduction of the Charter of Rights and Freedoms in 1982, human rights cases were usually decided on the basis of jurisdiction, thus severely limiting the ability of activists to challenge discriminatory laws. Second, activists who wish to limit the allocation of rights to gays and lesbians have used arguments regarding provincial rights to frame the debate as a question of constitutionality rather than of strictly human rights [...]
The Growing Importance of Municipal Empowerment in the Canadian Federation and the Need for a “Big Cities Collective”
Authors: Bech-Hansen Lauren
Published: October 2019

The Canadian federal-provincial system of government is recognized as one of the most unique in the world. While the founding fathers originally envisaged a relatively centralized system of government, reflecting their desire for a powerful national authority, political realities soon deemed that a more decentralized form of government would prevail. Influenced by both domestic and international factors, the Canadian federal system evolved throughout the 20th century. Provincial governments increasingly asserted their rights to attain the jurisdictional powers necessary to achieve their goals, and demanded to be placed on a near-equal footing with the federal government.1 The process by which this unfolded was long, grueling and conflict-ridden, but was essential if Canada were to function in the face of intense regionalism.2 The process reached in culmination in the Constitution Act of 1982, which enshrined the two-tier federal-provincial system. [...]
The European Refugee Crisis: transitioning the EU from state-centric ‘kingdoms’ to a federalist system of multi-level governance
Authors: Mighton Stephen
Published: October 2019

In an era where European integration has become increasingly questioned and where Euroscepticism battles the objectives envisioned by the Maastricht Treaty of 1992, the European Union (EU) desperately needs to revitalize its project of unification if its hopes to survive. Events of the last decade, such as the sovereign debt crisis, the global financial crisis, and the evolving refugee crisis, have challenged the efficacy of the EU and have seemingly undermined its legitimacy as a regulatory body. Taken individually, these crises pose a potent threat to the success of European integration and to the enlargement of member state unification. Most recently, the ongoing refugee crisis has created a sense of disunion within the EU giving way to a state of calamity as successive European efforts have failed at resolving this issue. Reeling from civil conflict and political turmoil, individuals from various regions, most notably Africa, the Middle East, and South Asia, have fled the dangers and uncertainties of their homes in order to seek refuge within neighbouring European countries. This arduous and sudden development has prompted commentators, such as former Greek finance minister Yanis Varoufakis, to claim that the solidarity of the EU is being threatened at a level not seen since the migrant crisis of 1945 during the Second World War.[...]
Federal-Provincial Relations and Conservatism in the Canadian West
Authors: Molineaux Connor
Published: October 2019

Regionalism has been a prominent feature of Western Canadian political culture even prior to Alberta and Saskatchewan joining confederation in 1905. One manifestation of this regionalism is through intergovernmental conflict, particularly jurisdictional disputes between the provincial and federal governments. These disputes have generally seen provincial governments of various ideological leanings cooperate, and yet decentralization–or expansion of provincial jurisdiction–is a position that has largely been advanced by conservatives in recent decade.1Is there an ideological connection between expansion of provincial jurisdiction and conservatism? This essay contends that the conservative ideology particular to Western Canada was uniquely influenced by the dynamic of federal-provincial relations in Canada because of particular features of the region’s brand of conservatism. This essay will demonstrate that ongoing disputes between western provinces–Alberta in particular–and the federal government, particularly over natural resource issues, have reinforced a dynamic of regionalism within Western Canadian conservatism, leading it to become the perennial feature of conservative policy, federally and provincially, that it is today.[...]
Child Care in Canada – What is the Federal Role?
Authors: Harshman Kristen
Published: October 2019

Childhood is the most critical stage in our life cycle due to the enormous growth and development that takes place. Skills such as reading, writing and communication are developed, and one’s emotional state is nurtured during the younger years of a child’s life (Government of Canada, 1994). The well-being of children, which includes emotional health, cognitive development, scholastic achievements and physical health among other things, can be impacted in a negative manner by the care they receive in their early years. This means that it is critical that children are cared for in a positive environment especially from birth until age five (Upperman & Gauthier, 1998). Education programs as well as support and awareness are all of great value in the policy field of child care, especially for children whose parents do not have the support of a family network to depend on for child care or the finances to send their children to private care centres (Battle & Torjman, 2000). The federal government, in cooperation with the provinces, has a critical role to play to help develop and promote high quality child care for Canada’s children through stable funding [...]
La peine de mort aux États-Unis
Authors: Côté Marie-Anne , Pelland Pierre-Luc
Published: October 2019

This research examines the place of the death penalty within the American society. Initially, based on the general statistics and on the important facts, the various practices of capital punishment are analyzed. The study of the historical evolution of the death penalty, the presentation of some famous cases, the analysis of the particular legislations existing from one State to another, as well as the perception of the death penalty by the American population make it possible to give a good overall picture of the current state of the capital sentence in the United States. Thereafter, the “checks and balances” principles that rules death penalty are analysed; clemency granted by the governors and the president, the power of the lobby, the limitation of competences of the different court and, finally, the individual and the collective rights appearing in the Constitution.
Développement des Pouvoirs de l’État Fédéral Américain dans un Contexte de Crise Économique: une Étude de Case Portant sur le New Deal et le Système des Poids et Contrepoids.
Authors: Houle David
Published: October 2019

This article analyses the principles of the American system of ‘checks and balances’ during the period of economic and social turmoil under the presidency of Franklin D Roosevelt – creator of the New Deal policy. The author describes the fundamental principles of the American system of ‘checks and balances,’ while commenting on historical context and the American political system in general. Finally, the author concludes with the suggestion that the federal executive capitalized on the Great Depression by increasing its power over the United State’s administration.
The Effect of Unitary and Federal State Structures on Governance in the Federal Republic of Germany and the United Kingdom of Great Britain and Northern Ireland
Authors: Sznurkowski Jan
Published: October 2019

Abstract unavailable. See PDF for full text.
L'Alberta et la Fédération Canadienne
Authors: Tousignant Simon
Published: October 2019

Abstract unavailable. See PDF for full text.
Le Fédéralisme en Contexte Multi-Ethnic Est-il Viable à Long Terme?
Authors: Mekouar Merouan
Published: October 2019

Abstract unavailable. See PDF for full text.
À la Rencontre de Deux Antinationalistes: La Pensée Nationaliste de Trudeau et Kedourie
Authors: Perreault Maxime
Published: October 2019

Abstract unavailable. See PDF for full text.
Assessing Bill C-36: The Myth of Inalienable Human Rights
Authors: Falcomer Natalie
Published: October 2019

The concept of human rights circumvents an exact definition and despite its universal acceptance there is a lack of agreement on how it should be approached.2 Human rights may be defined as inalienable rights which are acquired purely by virtue alone. In comparison, some scholars view human rights in a “strict legal sense” as such rights are created by contract or statute and are therefore, “removable or alterable.”3 The dominant notion of human rights accepts the theory of “natural rights” as political, legal, economic and egalitarian rights which are both morally and legally justifiable.4 More importantly, it is argued that these abstract principles only become relevant as they are codified in detailed legislation, otherwise, “they remain incomplete and ineffective in affording [...]
RABSON-MENDENHALL SYNDROME IN TWINS
Authors:   Department of Endocrinology, Avicenna Tajik State Medical University, Niyazova Nargis Fazlikhudoevna , Inoyatova Nigina Azizovna ,   Department of Endocrinology, Avicenna Tajik State Medical University, Anvarova Shakar Saidoromovna ,   Department of Endocrinology, Avicenna Tajik State Medical University, Ismoilova Mijgona Nodirovna ,   Department of Pediatric Endocrinology, City Medical Center № 1 named after Akhmedov Karim, Samieva Shahnoza Timurovna ,   Department of Endocrinology, Avicenna Tajik State Medical University, Nuraliev Lukmon Yusufovich ,   Department of Endocrinology, Avicenna Tajik State Medical University
Published: October 2019

Objective: The article presents a rare clinical case of twins with Rabson-Mendenhall syndrome. To this day, about 55 cases of this syndrome have been described in the literature. The exact incidence of the disease is unknown, which may be due to early prenatal mortality. The syndrome occurs in children of both sexes. The Rabson-Mendenhall syndrome characterized by the delay in physical development, anomaly of the development of teeth and nails, thinning of subcutaneous fat, dry skin. The earliest signs of the syndrome are hyperpigmentation and hyperkeratosis of the skin in the neck, armpits and groin areas, which are signs of severe insulin resistance. Diabetes mellitus develops in childhood, has a labile course, and accompanied by frequent signs of ketoacidosis and specific microvascular complications. Keywords: Rabson-Mendenhall syndrome, insulin resistance, skin hyperpigmentation, hyperinsulinemia, hyperglycemia
DIAGNOSIS OF POSTOPERATIVE PELVIC ADHESIONS IN WOMEN WITH CHRONIC PELVIC PAIN ON THE BACKGROUND OF UNDIFFERENTIATED CONNECTIVE TISSUE DYSPLASIA
Authors:   Department of Obstetrics and Gynecology, Ryazan State Medical University named after acad. I.P. Pavlov, Repina Natalia ,   Department of Obstetrics and Gynecology, Ryazan State Medical University named after acad. I.P. Pavlov, Dmitrieva Maria ,   Department of Mathematics, Physics and Medical Informatics, Ryazan State Medical University named after acad. I.P. Pavlov
Published: October 2019

Objective: To optimize the diagnostic accuracy of the postoperative adhesion process on the background of undifferentiated connective tissue dysplasia (UCTD) in patients with chronic pelvic pain Methods: The study conducted based on the Regional Clinical Hospital "Regional Clinical Perinatal Center", during which 60 patients diagnosed with tubal and peritoneal infertility. Patients divided into 2 groups based on a modified scoring scale of T. I. Kadurina. A study of genotype-phenotypic predictors carried out by analyzing the expression of UCTD by the method of profiling phenotypic markers, according to a modified scale of T.I. Kadurina. The study of polymorphism of VEGF 634 [rs2010963], IL6-174 [rs1800795] genes, and the evaluation of the adhesion process according to the classification system of the American Fertility Society, the genetic predisposition to the development of the adhesion process by the method of genotyping acetylation and pain intensity on a visual analogue scale. Results: Patients with the grade of UCTD scores equal to 10 or more according to the modified scale of T.I. Kadurina assigned to the high-risk group for pelvic peritoneal adhesions (PPA). Diagnosis of predisposition to adhesions by methods of determining the type of acetylation and ultrasound suggests the presence of adhesions in the small pelvis before surgery in 76.66% and 65% of those examined respectively. The molecular-genetic predictors of UCTD are C/C IL6-174 allele C and C/G VEGFA 634 allele G. The intensity of chronic pelvic pain in the adhesive process depends on the stage of the latter. To predict the risk of development of PPA, the developed mathematical model based on P = 1/(1+еЂ(–z)) and independent predictors should be used: myopia, mitral valve prolapse, IL6-174 [rs1800795], VEGFA 634 [rs2010963] and phenotype of acetylation. Conclusion: Using the method of binary logistic regression on the basis of clinical, anamnestic, experimental and molecular-genetic data makes it possible to determine the probability of development of PPA on the background of UCTD using the formula: P = 1/(1+еЂ(–z)). Keywords: Pelvic peritoneal adhesions, chronic pelvic pain, acetylation, binary logistic regression
CURRENT PROBLEMS OF INTEGRATION WORK OF THE DUSHANBE AMBULANCE SERVICE WITH CITY HEALTH CENTERS, NURSING CARE HOSPITAL AND OTHER PROFILE SERVICES
Authors:   Department of Public Health, Economics and Health Management with the Course of Medical Statistics, Institute of Postgraduate Education in Healthcare of the Republic of Tajikistan, Muminzoda Bobodzhon Gafor , Mirzoev Fatkhullo Khayrulloevich ,   Center for Emergency Medical Care of Dushanbe
Published: October 2019

Objective: Examining issues of continuity of the ambulance service (AS) with primary health care, Nursing Care Hospital and other profile services. Methods: An analysis of the activities of the AS station, Nursing Care Hospital, city health centers, large hospitals were carried out. The materials of the Traffic Police Department of Dushanbe were used in the victims of road accidents, as well as the existing normative legal acts and regulating the activities of the Ambulance Medical Care. Results: The need for medical social assistance (hospital stage) increased 4 times. Number of AS calls in the working hours health centers increased by 45.3%. The number of patients, who died in an accident before the arrival of AS, due to the lost "golden hour", was 13.9%. Conclusion: Rational use of the possibilities of the Nursing Care Hospital, Health Centers, the extension of the bed fund for medico-social care, and the adoption of a number of integrated measures a legislatively and organized nature, including measures at reducing fragmentation of health care can significantly reduce the load on the ambulance. Keywords: Ambulance service, integration of ambulance service, Nursing Care Hospital, city health centers, profile services
PECULIARITIES OF DIAGNOSTICS AND COURSE OF UTERINE CERVICAL CANCER AMONG HIV-INFECTED WOMEN
Authors:   Department of Oncology, South Ural State Medical University, Bekhtereva Svetlana Aleksandrovna , Yaytsev Sergey Vasilievich ,   Department of Oncology, South Ural State Medical University, Akhetov Amir Amantaevich ,   Medical Centre Hospital of President’s Affairs Administration of the Republic of Kazakhstan, Shanazarov Nasrulla Abdullaevich ,   Medical Centre Hospital of President’s Affairs Administration of the Republic of Kazakhstan, Asabaeva Rita Iskandеrovna ,   Department of Oncology, South Ural State Medical University; Regional Oncological Dispensary of the Akimat of the South Kazakhstan Region
Published: October 2019

Objective: To assess the clinical course of uterine cervical cancer (UCC) against the background of HIV infection and its complex diagnosis. Methods: A retrospective analysis carried out to 847 outpatient cards of patients for the period 2016-2017. Of these, 17 were HIV-positive. Two groups were formed: group I – patients with UCC on the background of HIV, group II – patients with UCC without HIV. The mean age was 37.4±0.2 and 52.8±0.3 years, respectively. Stages of UCC in group I: IIB – 6 (35.5%), IIIA – 4 (23.5%), IIIB – 6 (35.5%), IVB – 1 (5.5%); in the II group: IB – 3 (15%), IIB – 10 (50%), IIIB – 6 (30%), IVB – 1 (5%). Distribution according to the histological structure in group I: squamous nonkeratinized cancer – 11 (68.75%), keratinizing – 1 (6.25%), adenocarcinoma – 4 (25%). In group II: squamous nonkeratinized cancer – 13 (65%), squamous keratinizing – 3 (15%), adenocarcinoma – 4 (2%). The groups were comparable in treatment methods: in both groups, chemoradiation therapy was used according to standard schemes. Results: Indicators in the I group: lethality – 4 (23.5%), stabilization – 5 (23.5%), progression – 8 (53%); in the second group: lethality – 1 (5%), stabilization – 14 (70%), progression – 5 (25%). Conclusion: UCC in the background of HIV infection occurs at an earlier age. The predominance of stage IIB disease and squamous nonkeratinized cancer in both groups was noted. Mortality within the first year, stabilization and progression in the I and II groups were 23.5%, 23.5%, 53% and 5%, 70%, 25%, respectively. Keywords: Human immunodeficiency virus (HIV), uterine cervical cancer, lethality, stabilization, progressing.
THE SEVERITY AND TENSION OF THE DRIVERS OF PASSENGER VEHICLES WHILE WORKING IN CONDITIONS OF THE BIG CITY
Authors:   Department of Hygiene and Ecology, Avicenna Tajik State Medical University, Nushervoni Biloli Khaliliyon , Babaev Abdunaim Babaevich ,   Department of Hygiene and Ecology, Avicenna Tajik State Medical University
Published: October 2019

Objective: To give a hygienic assessment of the severity and tension of the drivers of passenger vehicles while working in conditions of the big city Methods: The study involved 40 drivers of buses «AKIA» (produced by Turkey), «LiAZ» and trolleybuses of the brand «TIU» (produced by Russia), which are a part of the Dushanbe park. Studies were conducted on the magnitude of statistical load before the start of the shift and at the end of the working day, being forced to work postures, the duration of concentrated observation, nervously-emotional tension with the help of corrective tables of Anfimov and Platonov, as well as chronometric observations of the working day in the dynamics of the work shift. Results: The analysis showed that almost all drivers of passenger vehicles performed overtime during the entire working shift. It has been established that the majority of drivers were engaged in basic production operations on average during 13-14 hours of work shift, which is higher than the average standard 10-50%. Conclusion: The conditions and nature of the work of drivers of passenger vehicles are harmful and dangerous due to high nervous and emotional tension and irrational organization of the work and rest regime. Keywords: Passenger vehicle , driver, working conditions, severity and tension of labor, work and rest regime.
Concentraciones plasmáticas de linfopoyetina estromal tímica en niños afectados por virus dengue
Authors: Pastrana David , Muñoz Jhonny K. , Ortíz Felipe , Vega Rocío , Rodríguez Jairo A. , Salgado Doris , Rodríguez Luz Stella , Narváez Carlos F.
Published: October 2019

La linfopoyetina estromal tímica (TSLP) es un citoquina recientemente descrita que juega un papel clave en la fisiopatología de enfermedades alérgicas y parasitarias. La TSLP, luego de ser producida por el epitelio en respuesta a diferentes estímulos como componentes bacterianos y virales, condiciona a células dendríticas locales a generar una respuesta de linfocitos Th2. En el dengue, una enfermedad viral febril endémica en Colombia, un predominante perfil de citoquinas Th2 ha sido descrito en los niños que presentan formas severas y potencialmente letales de la enfermedad. Aquí se determinaron por ELISA, las concentraciones plasmáticas de TSLP en niños con dengue en fase aguda y convaleciente de la enfermedad, comparándolos con los niveles presentes en niños sanos y atópicos como controles. Los resultados indican que no hay diferencias significativas en las concentraciones plasmáticas de TSLP entre los niños sanos y los niños infectados con dengue en fase aguda. Sin embargo, una disminución significativa fue encontrada en los niños infectados entre la etapa aguda y convaleciente de la infección. Cuando se compararon los niveles de TSLP con el número de plaquetas, un conocido marcador de severidad en el dengue, no hubo correlación. Estos hallazgos apoyan la hipótesis de que el TSLP plasmático podría no estar implicado directamente en la fisiopatología de la infección por virus dengue. Otros factores de polarización de linfocitos T locales y sistémicos deberían ser evaluados.
Infección respiratoria aguda en primera infancia, estudio de casos y controles, Suaza 2011
Authors: Duran Cheylans , Tribiño Yuliette
Published: October 2019

La Infección Respiratoria Aguda (IRA) se encuentra dentro de las cinco primeras causas de morbilidad en primera infancia en el municipio de Suaza, Huila. Aunque se realizan acciones en salud pública encaminadas a la protección de la madre y el menor, no se presenta una disminución estadísticamente significativa en la incidencia de la patología. Con el fin de establecer los factores asociados a la presentación de la enfermedad, se realizó un estudio de casos y controles prospectivo entre marzo y abril de 2011. Los casos fueron niños menores de cinco años con diagnóstico de IRA según lo estipulado en el protocolo de vigilancia en salud pública para IRA y los criterios del CIE 10; los controles eran niños sin diagnóstico de IRA en el mismo grupo de edad, vecinos de los casos. Se estudiaron 176 menores de cinco años (88 casos y 88 controles), encontrándose mayor incidencia de la patología en la zona rural. No se hallaron factores de riesgo asociados a IRA y contrario a lo esperado, se presentaron como factores protectores: ingreso menor a un salario mínimo legal mensual (OR= 0,49; IC95 %: 0,24–0,97; ji = 4,24; p= 0,039), y bajo peso del niño al nacer (OR= 0,48; IC95 %:0,26– 0,87; ji = 5,87; p = 0,01). Aunque no se encontraron factores de riesgo para la presentación de la patología, no se puede asegurar que no existan, por esto se requieren nuevos estudios, donde se prolongue el tiempo de investigación y aumente el tamaño de muestra.
Evaluación de la ansiedad preoperatoria en pacientes sometidos a anestesia general. Estudio observacional
Authors: Leon-Girón Luisa F , Betancourt Cañas Jhoanna , Orozco-Chamorro Claudia M , Cabra-Bautista Ginna P , Calvache José A
Published: October 2019

Introducción: La ansiedad es una respuesta adaptativa del ser humano ante el peligro. El acto anestésico quirúrgico como generador de ansiedad se relaciona con mayor vulnerabilidad y difícil control del dolor postoperatorio, estancia hospitalaria prolongada, mayor tasa de accidentes anestésicos y vulnerabilidad a infecciones. Este estudio estimó la prevalencia de ansiedad preoperatoria en un grupo de pacientes sometidos a anestesia general mediante la escala de Ansiedad Preoperatoria y de Información de Ámsterdam (APAIS). Métodos: Estudio observacional de corte transversal con pacientes que recibieron anestesia general en un hospital de III nivel de atención. Se obtuvo información sociodemográfica y clínica. Se determinó la prevalencia de ansiedad preoperatoria mediante la escala APAIS (utilizando un punto de corte de 11) y los potenciales factores asociados. Se realizó un análisis descriptivo y se calcularon odds ratios para las asociaciones. Además, se construyó un modelo de regresión logística para ajustar el efecto de las covariables en la presentación de ansiedad. Resultados: La prevalencia de ansiedad fue de 13% [IC95% 7%-18%]. Las mujeres, los pacientes ambulatorios, clasificación ASA I y sometidos a cirugía mayor sin antecedentes de procedimientos quirúrgicos previos presentaron una mayor frecuencia de ansiedad. La mayoría de los pacientes presentaban una baja necesidad de información (76,8%). Tras el análisis ajustado, no se encontraron variables asociadas de forma importante a la presentación de ansiedad. Conclusiones: Se documentó una baja prevalencia de ansiedad y una baja necesidad de información por parte de los participantes. Se requiere continuar la investigación en el área en Colombia.
Ad Intrusiveness dan Sikap Konsumen terhadap Iklan On-Line pada E-Commerce
Authors: Raharjo Wahyu , Widyastuti Widyastuti
Published: October 2019

There are lots of online advertisements presented by E-commerce, but online advertising in the form of remarketing is the most intrusive advertisement. Remarketing ad is included as an ad intrusiveness which is very disturbing and can build a negative attitude towards ad, and it will make a negative purchase intention too. But in reality, this advertisement is very developed and almost E-commerces implement it, while what happens is that many consumers actually feel annoyed. The purpose of this study is to analyze and discuss the effect of ad intrusiveness in the form of remarketing toward purchase intention of E-commerce with an attitude toward ad as an intervening variable. The sampling technique used is non-probability sampling with judgmental sampling method. The sample used was 220 respondents. Respondents in this study were E-commerce users aged 19 and above who had seen ad intrusiveness in the form of remarketing. Questionnaire uses likert scale and  processing using path analysis. The results show that ad intrusiveness has a negative and significant effect on attitude toward ad and attitude toward ad has a positif and significant effect ad toward purchase intention.
Analisis Faktor-Faktor Consumer Engagement pada Media Sosial Twitter Cinema XXI
Authors: Handayaningrum Oktaviana Nur
Published: October 2019

Cinema XXI is the biggest cinema network in Indonesia. The high number of social media users in Indonesia has made Cinema XXI no longer difficult to embrace all of its customers. Being able to mantain long-term relationships, understanding what consumer wants and needs are important to keep Cinema XXI as the ruler of the cinema market in Indonesia. To do this, Cinema XXI needs to create consumer engagement. Consumer engagement is a marketing investment to create long-term relationship with consumers. Therefore, this research aims to determine what consumer engagement factors were successfully created by Cinema XXI to become the ruler of the cinema market in Indonesia with more than 11 million followers on Twitter social media accounts. By using the Slovin formula, the number of samples in this research were 400 respondents. The factors used amounted to 18 factors obtained from previous research, this  reasearch uses quantitative descriptive methods with factor analysis techniques, calculation with SPSS 16. The results of this research state that from the existing dimensions reduced into three new dimensions, namely affective behavioural engagement with sub-dimensional dominance of enjoyment with 0,765, cognitivie behavioural engagement with sub-dimensional dominance of attention with 0,834 and informative engagement with sub-dimensional dominance of up-to-date information with 0,873.
Difference between financial intelligence on millennials, gen x, and baby boomers
Authors: Anastasia Njo , Setiadiwiria Oka Christian , Kunto Yohanes Sondang
Published: October 2019

The financial management of each individual depends on his financial intelligent. This study aims to examine the differences between financial knowledge and financial behavior, which are a combination of financial intelligent in each generation, namely the millennials, Gen X, and baby boomers. The sample used consisted of 100 respondents in each generation, selected using purposive sampling technique. Data collection used questionnaires distributed by online and hardcopy, which is then processed to test the differences using the ANOVA test. The results of the analysis showed that there are significant differences in financial intelligence on millennials, Gen X, and baby boomers. However, there were no difference in financial intelligence between millennials and Gen X. This proves that differences in generations that have different growth periods will have different levels of financial knowledge, resulting in differences in financial behavior.
Why relational marketing impacts on bank's customer satisfaction?
Authors: Harahap Dedy Ansari , Amanah Dita , Yakob Rubayah
Published: October 2019

This study examines the impact of relational marketing to customer satisfaction with the case study on Postgraduate Students at Universitas Pendidikan Indonesia who become the customer of Bank BNI Setiabudhi, Bandung. The study aims to determine the impact of relational marketing’s variables such as the level of commitment, empathy, reciprocity and trust to customer satisfaction. The research method is an explanatory research with probability sampling as the sampling method. There are 110 samples that collected through questionnaire. The samples are randomly selected and measured by Likert scale. Furthermore, the data is analyzed  with Multiple Linier Regression methods. The result of study implies that the variables of relational marketing impact positively to the level of customer satisfaction. The dimension of “trust” gives the strongest effect on customer satisfaction and the dimension of “empathy” gives the weakest effect on customer satisfaction.
The impact of marketing approach changes to school’s selection decision
Authors: Afriyani Afriyani , Harris Ibnu , Fata Muhammad Adli
Published: October 2019

Maitreyawira Playgroup/Kindergarten School is one of the long standing and reputable educational institutions in Batam. However, promotion strategy needs to be carried out to communicate educational services to the community in order to influence individual’s school selection decisions. In this study, there are four variables in the promotional mix element. This research is intended to determine the effectiveness of marketing which is influenced by changes in marketing functions. The data collection method in this study was carried out by distributing questionnaires to the parents whose their children study in the Maitreyawira Playgroup/Kindergarten School in Batam and considered as the new service user who experience the service. The data analysis was conducted into stages such as F test, t test, and multiple linear regression analysis. The results of this study indicate that WOM (word of mouth) has an influence on Maitreyawira Playgroup/Kindergarten school selection decisions, while e-WOM (electronic word-of-mouth) does not influence the decision to choose Maitreyawira Playgroup/Kindergarten schools.
Siyasi Partilerin 2019 Yerel Seçimlerinde Web Sitesi Kullanımı ve Karşılaştırmalı Analizi
Authors: ARĞIN Emrah
Published: October 2019

Kitle iletişim araçları; yasama, yürütme ve yargıdan sonra
dördüncü bir güç olarak kabul görmektedir. Günümüzde en etkili ve yaygın
kullanılan kitle iletişim aracı ise internettir. İnternet ülkemizde
siyasetçiler tarafından yardımcı ve tamamlayıcı bir araç olarak sıklıkla
kullanılmaktadır ve bundan sonra da kullanılmaya devam edecektir. Toplum
üzerinde önemli etkisi olan internet medyası, Web 2.0’ın gelişimiyle birlikte
çift yönlü iletişime olanak tanıyan yapıya kavuşmuştur. Siyasi partiler, geleneksel
kitle iletişim araçlarıyla birlikte, seçmenlerle etkileşim halinde olabilmek
için internetin bütün imkânlarından faydalanmaktadır. Bu çalışmada, mecliste
grubu bulunan AK PARTİ, CHP, İYİ PARTİ, MHP ve HDP'nin 31 Mart 2019 yerel
seçimleri süresince kurumsal Web sayfaları karşılaştırmalı olarak analiz
edilmektedir. Siyasi partilerin kurumsal Web sayfaları, işlevsellik ve
tasarımsal özellikleri bakımından karşılaştırılarak değerlendirilmiştir. İçerik
analizi yönetimi ile elde edilen bulgulara göre, Siyasi partilerin, kurumsal
Web sayfalarını propaganda ve kamuoyunu bilgilendirme amacıyla sıklıkla
kullandığı tespit edilmiştir.
Influence of CuO nanoparticles in enhancing the overall heat transfer around a square cylinder
Authors: Bouakkaz Rafik , Khelili Yacine , Abdelouahed Aliouali
Published: October 2019

In this study, steady flow and heat transfer through a copper–water nanofluid around a square cylinder was investigated numerically by using a finite-volume method for Reynolds numbers of 10-40. Furthermore, the range of nanoparticle volume fractions () considered is 0 ≤  ≤ 0.04, with three different nanoparticle diameters dnp = 30, 60 and 90 nm. The variation of the local and the average Nusselt numbers with Reynolds number, and volume fractions are presented for the range of above conditions. The averaged Nusselt number showed clear enhancement comparing with the base fluids. This enhancement is more apparent in flows with higher particle volume concentration, whereas the particle diameter imposes an opposing effect on the heat transfer characteristics.
Effect of Prenatal Citalopram Exposure on Motor and Cognitive Functions of Rats
Authors: ZAİMOĞLU Ayşenur , AKYÜZ Bahar , BİLGE S. Sırrı
Published: October 2019

Aim: Physicians mostly prescribe selective serotonin reuptake inhibitors in the treat-ment of depression in pregnancy. However, there is little information on teratogenic effects of selective serotonin reuptake inhibitors. This study aims to investigate the ef-fects of prenatal exposure to citalopram, one of the most prescribed antidepressants, on developmental characteristics, reflex and motor functions of rat pups. Materials and Methods: 12-14 weeks old, pregnant Sprague-Dawley rats were used in the experiments. Rats were divided into 3 groups and separated into individual cag-es. When treatment groups received 5 and 20 mg/kg/d citalopram by orogastric ga-vage from gestational days 1 to 18, control group received the same amount of saline (2 ml/kg/d). After birth duration of gestation, number of live and dead pups and gross malformation are evaluated. Eye opening, pinna detachment, incisor eruption, the development of fur and weight gain were monitored as developmental parameters. Markers for reflex development were identified as righting reflex, negative geotaxis and grip response. Motor developments and cognitive functions were established with locomotor activity test, T-maze, holeboard, Y-maze and passive avoidance test. Results: Developmental parameters, reflex, motor and cognitive development as-sessments of pups were not significantly different in treatment groups compared to control group. Conclusion: The results of the study show that prenatal exposure to citalopram has no effect on motor and cognitive functions of rat offspring.
Miringoplastide Greft Materyali Olarak Temporal Kas Fasyası ve Konkal Kıkırdak Kullanımının Erken ve Geç Dönem Anatomik ve Fonksiyonel Karşılaştırılması
Authors: GÜLER İsmail , BAKLACI Deniz , KUZUCU İhsan , KUM Rauf Oğızhan , ÖZCAN Müge
Published: October 2019

Amaç: Timpanik membran perforasyonlarının onarımı için uygulanan miringoplasti ameliyatlarında temporal kas fasyası (TKF) ve konkal kıkırdak (KK) greftlerinin erken ve geç dönem anatomik ve fonksiyonel sonuçları karşılaştırıldı.Gereç ve Yöntemler: Çalışmaya kliniğimizde Nisan 2016 - Nisan 2018 tarihleri arasında opere edilen toplam 110 miringoplasti hastası dahil edildi. Her hasta için yaş, cinsiyet, greft materyali (TKF/KK), preoperatif ve postoperatif işitme seviyeleri, greft başarısı ve fonksiyonel başarı (hava-kemik aralığı < 10 dB) kaydedildi .Bulgular: Erken dönem greft başarısı açısından TFK (%93.5) ve KK (%93.8) grupları arasında anlamlı bir fark yoktu. (p= 0.966). Geç dönem greft başarısı açısından TFK (%85.5) ve KK (%91.7) grupları arasında anlamlı bir fark yoktu. (p= 0.319). Erken dönem fonksiyonel başarı açısından TFK (%87.1) ve KK (%85.4) grupları arasın-da anlamlı bir fark yoktu. (p= 0.799). Geç dönem fonksiyonel başarı açısından TFK (%82.3) ve KK (%83.3) grupları arasında anlamlı bir fark yoktu. (p= 0.882). Sonuç: Çalışmamızın sonucu TKF ve KK greftlerinin erken dönemde benzer başarı oranlarına sahip olduğunu gösterdi. Konkal kartilaj, geç dönem greft başarı oranının yüksek olması ve işitme üzerinde olumsuz bir etkisi olmaması nedeniyle primer mir-ingoplastide güvenle tercih edilebilir.
The Role of Arthroscopic Decompression in Subacromial Impingement Syndrome
Authors: ATİK Aziz
Published: October 2019

Aim: The aim of this study was to evaluate the clinical results of patients who had arthroscopic subacromial decompression for the diagnosis of subacromial impingement syndrome which is characterized by compression of the coracoacromial arc on rotator cuff tendons. Patients and Methods: We have evaluated the Constant scores, rest VAS and motion VAS scores of 25 patients who had arthroscopic subacromial decompression after six months of failed conservative treatment, at the preoperative day, 15th day and 6th month after the operation. Results: There was a statistically significant difference between pre-operative and 15th day / 6th month scores with Mann Whitney U test (p <0.0001). We found that the patients’ pain decreased and shoulder functions improved statistically. Conclusion: We believe that the choice of treatment for early stages of subacromial impingement syndrome is conservative, but if complaints persist even six months after conservative treatment, then arthroscopic subacromial decompression is a good choice of treatment.