bluuebunny/crossref_metadata_2025 huggingface dataset:
Sodium alginate/gelatin hydrogels loaded with adipose‐derived mesenchymal stem cells promote wound healing in diabetic rats
Authors: Sheng Wei , Song Qi , Su XiangZheng , Lu Yao , Bai YuZhe , Ji FengKun , Zhang Li , Yang RunGong , Fu Xiaobing
Published: January 2023

Background

Chronic refractory wounds are a common complication in diabetic patients. Adipose‐derived mesenchymal stem cells (ASCs) have been shown to play an essential role in diabetic wound repair.

Aims

To determine whether a composite of ASCs and sodium alginate/gelatin (Gel‐Al) hydrogel can promote diabetic wound healing.

Methods

Full‐thickness cutaneous wounds were created in streptozotocin‐induced diabetic rats prior to treatment with Gel‐Al hydrogels loaded with ASCs. Hydrogel biocompatibility and wound healing were analyzed. Hematoxylin and eosin staining, Masson staining, immunofluorescence, enzyme‐linked immunosorbent assays (ELISA), and quantitative real‐time PCR were performed for the assessment of cellular responses.

Results

Compared to the control group or Gel‐Al alone group, the combination of Gel‐Al and ASCs promoted wound closure, facilitated granulation tissue regeneration and collagen deposition, and upregulated the expression of vascular endothelial growth factor (VEGF), platelet‐derived growth factor (PDGF), epidermal growth factor (EGF), and endothelial cell marker CD31. Moreover, the combination of Gel‐Al and ASCs decreased interleukin‐6 (IL‐6) and interleukin‐1β (IL‐1β) expression, increased transforming growth factor beta1 (TGFβ1), interleukin‐10 (IL‐10), interleukin‐4 (IL‐4) and interleukin‐13 (IL‐13) expression, and increased M2 macrophage polarization.

Conclusions

Gel‐Al hydrogels loaded with ASCs accelerate diabetic wound healing. The Gel‐Al hydrogel‐based ASC system therefore represents an innovative therapeutic strategy for diabetic wound repair.
Validation of a novel point‐of‐care test for alanine aminotransferase measurement: A pilot cohort study
Authors: Howell Jessica , Van Huy , Pham Minh D. , Sawhney Rohit , Li Fan , Bhat Purnima , Lubel John , Kemp William , Bloom Stephen , Majumdar Avik , McCaughan Geoffrey W. , Hall Samuel , Spelman Timothy , Doyle Joseph S. , Hellard Margaret , Visvanathan Kumar , Thompson Alexander , Drummer Heidi E. , Anderson David
Published: January 2023

Background

Alanine aminotransferase (ALT) measurement is essential for evaluation of liver disease. We validated a novel rapid point‐of‐care (POC) test for ALT1 against laboratory ALT.

Methods

Stored plasma samples from adults with chronic liver disease (Test cohort n = 240; Validation cohort n = 491) were analysed using the BioPoint® antigen immunoassay POC ALT1 lateral flow test, which provides quantitative ALT results (Axxin handheld reader) or semi‐quantitative results (visual read, cut off 40 IU/ml). The accuracy of POC ALT1 to detect ALT > 40 IU/L was determined by ROC analysis. In patients with chronic hepatitis B, treatment eligibility (EASL criteria) was determined using POC ALT1 and compared to laboratory ALT.

Results

POC ALT1 test had good accuracy for laboratory ALT > 40 IU/L: AUROC 0.93 (95% CI: 0.89–0.96) in the Test cohort and AUROC 0.92 (95% CI: 0.88–0.95) in the Validation cohort. POC ALT1 cut off of 0.8 for ALT > 40 IU/L maximised sensitivity (97%) and specificity (71%) in the Test cohort (42% laboratory ALT > 40 IU/L) and yielded PPV 84% and NPV 91% in the Validation cohort (19% laboratory ALT > 40 IU/L). Semi‐quantitative POC ALT1 had good accuracy for laboratory ALT in the Validation cohort (AUROC 0.85, 95% CI: 0.81–0.99; sensitivity 77% and specificity 93%). Combined with HBV DNA and transient elastography, both quantitative and semi‐quantitative POC ALT1 tests had good accuracy for excluding hepatitis B treatment needs (sensitivity 96%, specificity 78% and NPV 99%).

Conclusion

The POC ALT1 test had good accuracy for elevated ALT levels and for determining treatment eligibility among people with chronic hepatitis B.
PNPLA3 I148M and response to treatment for hepatic steatosis: A systematic review
Authors: Boeckmans Joost , Gatzios Alexandra , Schattenberg Jörn M. , Koek Ger H. , Rodrigues Robim M. , Vanhaecke Tamara
Published: January 2023

Background

It is unclear whether the patatin‐like phospholipase domain‐containing protein 3 (PNPLA3) rs738409 C‐to‐G single nucleotide polymorphism, resulting in the substitution of isoleucine to methionine at position 148 (I148M), impedes regression of hepatic steatosis when treating non‐alcoholic fatty liver disease (NAFLD).

Objectives

Investigate if carriage of the PNPLA3 148M allele affects the anti‐steatotic efficacy of all possible anti‐NAFLD interventions, identify gaps in current knowledge and provide guidance for individual treatment.

Methods

Research available in public databases was searched up to 13 November 2022. Studies were included if a treatment in NAFLD patients decreased hepatic steatosis in the pooled patient group or a PNPLA3 I148M polymorphism subgroup (II/IM/MM). The risk of bias was assessed using the Cochrane Risk‐Of‐Bias 2 Tool and the Newcastle–Ottawa Scale.

Results

Moderate evidence indicates that NAFLD patients homozygous for the PNPLA3 148M allele benefit less or not at all from omega‐3 carboxylic acids to decrease liver fat, while the PNPLA3 148I allele shows moderate benefit. Low evidence suggests that interventions employing lifestyle changes are more effective to reduce liver fat in NAFLD patients homozygous for the PNPLA3 148M allele compared to patients with wild‐type PNPLA3.

Conclusions

NAFLD patients homozygous for the PNPLA3 148M allele might not benefit from omega‐3 carboxylic acids to reduce hepatic steatosis in contrast to patients with wild‐type PNPLA3. Instead, patients with two PNPLA3 148M alleles should be especially advised to adopt lifestyle changes. Genotyping for PNPLA3 I148M should be encouraged in therapeutic studies for NAFLD.

Registration Number (Prospero)

CRD42022375028.
Multiple Reconstructive Osteotomy Treating Malunited Calcaneal Fractures Without Subtalar Joint Fusion
Authors: Wang Bowei , Guan Xin , Hu Yanjun , Jiang Guiyong , Lin Qingrong , Ye Jing , Xiang Dayong , Yu Bin
Published: January 2023

Objective

Various surgical techniques have been reported in treating calcaneal malunions over the decades, while the operations on single plane were accompanied by respective limitations. The purpose of this study is to evaluate the efficacy of a novel multiple reconstructive osteotomy for treating malunited calcaneal fractures without subtalar joint fusion.

Methods

From March 12, 2010, to August 17, 2017, 10 patients (10 feet) with malunited calcaneal fractures were treated with multiple reconstructive osteotomy with subtalar joint‐preserving operations. All patients were treated with a corrective osteotomy, joint realignment, soft tissue balancing, and secondary internal fixation at a mean of 5.6 ± 2.41 months since the initial injury. With the utilization of the multiple reconstructive osteotomy, the posterior facet was restored to preserve the subtalar joint. All patients were evaluated clinically and radiographically at a mean follow‐up of 3.04 ± 1.21 years.

Results

All patients were subjectively satisfied with the treatment. The average time to union was 12.2 ± 1.11 weeks. The American Orthopedic Foot and Ankle (AOFAS) ankle and hind foot score was 86.3 ± 4.45 (t = 27.64, P < 0.0001, paired t‐test), which was significantly higher than the preoperative assessment. Postoperative radiographic assessment revealed great improvement in Böhler's angle (from 25.4° to 86.3°), talocalcaneal height (65.15–72.68 mm) and Calcaneus‐talus angle (from 34.46° to 39.7°). One patient had mild discomfort after a 1‐h brisk walk. One patient was suspected to have early posttraumatic arthritis of the subtalar joint based upon radiographic evidence during the follow‐up, but the patients could walk normally for a long time without pain.

Conclusion

Multiple reconstructive osteotomy is an effective way to restore the calcaneal morphology and preserve the subtalar joint for selected calcaneal malunion.
Establishment and Verification of a Predictive Nomogram for New Vertebral Compression Fracture Occurring after Bone Cement Injection in Middle‐Aged and Elderly Patients with Vertebral Compression Fracture
Authors: Gao Wenxin , Chen Yungang , Wang Xiaoying , Liu Guoyan , Cui Kaiying , Guo Jinxing , Zheng Jianhu , Hao Yanke
Published: January 2023

Objective

New vertebral compression fracture (NVCF) occurring after bone cement injection in middle‐aged and elderly patients with vertebral compression fracture is very common. Preoperative baseline characteristics and surgical treatment parameters have been widely studied as a risk factor, but the importance of the patients' laboratory indicators has not been thoroughly explored. We aimed to explore the relationship between laboratory indicators and NVCF, and attempt to construct a clinical prediction model of NVCF together with other risk factors.

Methods

Retrospective analysis was performed for 200 patients who underwent bone cement injection (percutaneous kyphoplasty or vertebroplasty) for vertebral compression fractures between January 2019 and January 2020. We consulted the relevant literature and collated the factors affecting the occurrence of NVCF. Feature selection of patients with NVCF was optimized using the least absolute shrinkage and selection operator regression model, which was used to conduct multivariable logistic regression analysis, to create a predictive model incorporating the selected features. The discrimination, calibration, and clinical feasibility of the predictive model were assessed using the concordance index (C‐index), calibration plots, and decision curve analysis. Internal validation was performed using Bootstrap resampling verification.

Results

Time from injury to surgery exceeding 7 days, low osteocalcin levels, elevated homocysteine levels, osteoporosis, mode of operation (percutaneous vertebroplasty), lack of postoperative anti‐osteoporosis treatment, and poor diffusion of bone cement were independent risk factors for NVCF in middle‐aged and elderly patients with vertebral compression fracture after bone cement injection. The C‐index of the nomogram constructed using these seven factors was 0.895, indicating good discriminatory ability. The calibration plot showed that the model was well calibrated. Bootstrap resampling verification yielded a significant C‐index of 0.866. Decision curve analysis demonstrated that the greatest clinical net benefit for predicting NVCF after bone cement injection could be achieved with a threshold of 1%–91%.

Conclusion

This nomogram can effectively predict NVCF incidence after bone cement injection in middle‐aged and elderly patients with vertebral compression fracture, thus aiding clinical decision‐making and postoperative management, promoting effective postoperative rehabilitation, and improving the quality of life.
Comparison of Interobserver Agreement of Four Classification Systems for Lateral Clavicle Fractures between Two Groups of Surgeons: A Multicenter Study
Authors: Lin Jian , Sun Wei‐Jin , Chen Jian‐Hai , Dong Jing‐Ming , Bao Ding‐Su , Yan Ling , Ni Wei‐Dong , Xiang Ming , Ding Jian , Cai Ming , Song Jia‐Xiang , Mao Ming‐Gui , Wu Xiao‐Ming
Published: January 2023

Objective

Distal clavicle fracture classification directly affects the treatment decisions. It is unclear whether the classification systems implemented differ depending on surgeons' backgrounds. This study aimed to compare the interobserver agreement of four classification systems used for lateral clavicle fractures by shoulder specialists and general trauma surgeons.

Methods

Radiographs of 20 lateral clavicle fractures representing a full spectrum of adult fracture patterns were analyzed by eight experienced shoulder specialists and eight general trauma surgeons from 10 different hospitals. All cases were graded according to the Orthopedic Trauma Association (OTA), Neer, Jäger/Breitner, and Gongji classification systems. To measure observer agreement, Fleiss' kappa coefficient (κ) was applied and assessed.

Results

When only X‐ray films were presented, both groups achieved fair agreement. However, when the 3D‐CT scan images were provided, improved interobserver agreement was found in the specialist group when the OTA, Jäger/Breitner, and Gongji classification systems were used. In the generalist groups, improved agreement was found when using the Gongji classification system. In terms of interobserver reliability, the OTA, Neer, and Jäger/Breitner classification systems showed better agreement among shoulder specialists, while a slightly lower level of agreement was found using the Gongji classification system. For the OTA classification system, interobserver agreement had a mean kappa value of 0.418, ranging from 0.446 (specialist group) to 0.402 (generalist group). For the Neer classification system, interobserver agreement had a mean kappa value of 0.368, ranging from 0.402 (specialist group) to 0.390 (generalist group). For the Jäger/Breitner classification system, the inter‐observer agreement had a mean kappa value of 0.380, ranging from 0.413 (specialist group) to 0.404 (generalist group). For the Gongji classification system, interobserver agreement had a mean kappa value of 0.455, ranging from 0.480 (specialist group) to 0.485 (generalist group).

Conclusion

Generally speaking, 3D‐CT scans provide a richer experience that can lead to better results in most classification systems of lateral clavicle fractures, highlighting the value of digitization and specialization in diagnosis and treatment. Competitive interobserver agreement was exhibited in the generalist group using the Gongji classification system, suggesting that the Gongji classification is suitable for general trauma surgeons who are not highly experienced in the shoulder field.
Ethical and Legislative Standards in the Environment of Radio Broadcasters and Their Application into Practice
Authors: Bôtošová Ľubica , Brník Andrej , Levak Tomislav , Kupec Václav
Published: January 2023

The present scientific study deals with the legislative and ethical norms that apply in the environment of media production. The authors have focused their attention mainly on the media in post-communist countries, namely the Slovak and Czech Republics and Croatia. In the process of drafting, they have made a detailed analysis of the legislative norms, giving special emphasis to a brief historical overview of the development of these documents, where they also describe the work of radio journalists, how journalists’ sources of information are protected, and how the documents reflect new forms of media development, such as online media, streaming services, podcasts, etc. A similar analysis has also been made of ethical standards in the above-mentioned countries, particularly in terms of the possibility of applying existing codes of ethics specifically to radio broadcasting and radio workers, but also of new developments that a code of ethics should cover, such as comments on social networks, profiles of journalists, their statements, etc. The study also includes a questionnaire for radio workers who process information and focuses on how they apply ethical and legislative standards in practice. Thus, the aim of the submitted study is to compare the ethical and legislative framework of work in the radio media in selected post-communist countries of Europe and their application in practice.
Erdős–Hajnal for graphs with no 5‐hole
Authors: Chudnovsky Maria , Scott Alex , Seymour Paul , Spirkl Sophie
Published: January 2023

The Erdős–Hajnal conjecture says that for every graph there exists such that every graph not containing as an induced subgraph has a clique or stable set of cardinality at least . We prove that this is true when is a cycle of length five. We also prove several further results: for instance, that if is a cycle and is the complement of a forest, there exists such that every graph containing neither of as an induced subgraph has a clique or stable set of cardinality at least .
The integral Chow ring of , for odd
Authors: Cavalieri Renzo , Fulghesu Damiano
Published: January 2023

For any odd integer $d$, we give a presentation for the integral Chow ring of the stack $\mathcal {M}_{0}(\mathbb {P}^r, d)$, as a quotient of the polynomial ring $\mathbb {Z}[c_1,c_2]$. We describe an efficient set of generators for the ideal of relations, and compute them in generating series form. The paper concludes with explicit computations of some examples for low values of $d$ and $r$, and a conjecture for a minimal set of generators.
Statistical Comparison of Creep-Rupture Lifetime Predictions of Single and Two-Step Aged Wrought Haynes 282 Alloy
Authors: Cedro Vito , Render Mark , Chukwunenye Kelechi
Published: January 2023

The paired and Welch's t-tests were used to determine if statistically significant differences exist between the predicted creep rupture life of single- and two-step aged wrought Haynes 282 nickel superalloy. Both tests indicated that there is no difference in the temperature range of 700–800 °C. These results provide a quantitative perspective to support the conclusions reached in previous publications that the creep rupture strengths of wrought single- and two-step aged Haynes 282 are very similar or the same. The lack of creep rupture data above 800 °C for two-step aged H282 precluded extending the statistical analysis above that temperature.
Blind source separation by long-term monitoring: A variational autoencoder to validate the clustering analysis
Authors: De Salvio Domenico , Bianco Michael J. , Gerstoft Peter , D'Orazio Dario , Garai Massimo
Published: January 2023

Noise exposure influences the comfort and well-being of people in several contexts, such as work or learning environments. For instance, in offices, different kind of noises can increase or drop the employees' productivity. Thus, the ability of separating sound sources in real contexts plays a key role in assessing sound environments. Long-term monitoring provide large amounts of data that can be analyzed through machine and deep learning algorithms. Based on previous works, an entire working day was recorded through a sound level meter. Both sound pressure levels and the digital audio recording were collected. Then, a dual clustering analysis was carried out to separate the two main sound sources experienced by workers: traffic and speech noises. The first method exploited the occurrences of sound pressure levels via Gaussian mixture model and K-means clustering. The second analysis performed a semi-supervised deep clustering analyzing the latent space of a variational autoencoder. Results show that both approaches were able to separate the sound sources. Spectral matching and the latent space of the variational autoencoder validated the assumptions underlying the proposed clustering methods.
Heating Up to Keep Cool: Benefits and Persistence of a Practical Heat Acclimation Protocol in Elite Female Olympic Team-Sport Athletes
Authors: Fenemor Stephen P. , Driller Matthew W. , Gill Nicholas D. , Anderson Brad , Casadio Julia R. , Sims Stacy T. , Beaven C. Martyn
Published: January 2023

Purpose: Although recommendations for effective heat acclimation (HA) strategies for many circumstances exist, best-practice HA protocols specific to elite female team-sport athletes are yet to be established. Therefore, the authors aimed to investigate the effectiveness and retention of a passive HA protocol integrated in a female Olympic rugby sevens team training program. Methods: Twelve elite female rugby sevens athletes undertook 10 days of passive HA across 2 training weeks. Tympanic temperature (TTymp), sweat loss, heart rate, and repeated 6-second cycling sprint performance were assessed using a sport-specific heat stress test Pre-HA, after 3 days (Mid-HA), after 10 days (Post-HA), and 15 days post-HA (Decay). Results: Compared with Pre-HA, submaximal TTymp was lower Mid-HA and Post-HA (both by −0.2 [0.7] °C; d ≥ 0.71), while resting TTymp was lower Post-HA (by −0.3 [0.2] °C; d = 0.81). There were no differences in TTymp at Decay compared with Pre-HA, nor were there any differences in heart rate or sweat loss at any time points. Mean peak 6-second power output improved Mid-HA and Post-HA (76 [36] W; 75 [34] W, respectively; d ≥ 0.45) compared with Pre-HA. The observed performance improvement persisted at Decay by 65 (45) W (d = 0.41). Conclusions: Ten days of passive HA can elicit some thermoregulatory and performance benefits when integrated into a training program in elite female team-sport athletes. However, such a protocol does not provide a sufficient thermal impulse for thermoregulatory adaptations to be retained after 15 days with no further heat stimulus.
Systematic Discovery of a New Catalogue of Tyrosine-Type Integrases in Bacterial Genomic Islands
Authors: Zhang Gang , Yao Shigang , Liu Yunan , Fang Hailing , Song Yuqin , Wang Chao , Wei Dawei , Feng Jie
Published: January 2023

Site-specific recombinases or integrases have high specificity for DNA large fragment integration, which is urgently needed for gene editing. However, known integrases are not sufficient for meeting multiple integrations.
VelcroVax: a “Bolt-On” Vaccine Platform for Glycoprotein Display
Authors: Kingston Natalie J. , Grehan Keith , Snowden Joseph S. , Hassall Mark , Alzahrani Jehad , Paesen Guido C. , Sherry Lee , Hayward Connor , Roe Amy , Stephen Sam , Tomlinson Darren , Zeltina Antra , Doores Katie J. , Ranson Neil A. , Stacey Martin , Page Mark , Rose Nicola J. , Bowden Thomas A. , Rowlands David J. , Stonehouse Nicola J.
Published: January 2023

The hepatitis B core protein (HBc) forms noninfectious virus-like particles, which can be modified to present a capturing molecule, allowing suitably tagged antigens to be bound on their surface. This system can be adapted and provides the foundation for a universal “bolt-on” vaccine platform (termed VelcroVax) that can be easily and rapidly modified to generate nanoparticle vaccine candidates.
A High Dose of Dietary Berberine Improves Gut Wall Morphology, Despite an Expansion of
Enterobacteriaceae
and a Reduction in Beneficial Microbiota in Broiler Chickens
Authors: Dehau Tessa , Cherlet Marc , Croubels Siska , van Immerseel Filip , Goossens Evy
Published: January 2023

Dietary additives are widely used to reduce intestinal inflammation and enteritis, a growing problem in the broiler industry. Berberine, with anti-inflammatory, antioxidant, and antimicrobial activity, would be an interesting feed additive in this regard.
Phenomenology of strong interactions: towards an effective theory for low energy QCD
Authors: Issifu Adamu , Brito Francisco A.
Published: January 2023

In this paper, we develop models applicable to phenomenological particle physics by using the string analogy of particles. These theories can be used to investigate the phenomenology of confinement, deconfinement, chiral condensate, QGP phase transitions, and even the evolution of the early universe. Other confining properties such as scalar glueball mass, gluon mass, glueball-meson mixing states, QCD vacuum, and color superconductivity can also be investigated in these model frameworks. We use one of the models to describe the phenomenon of color confinement among glueballs at the end of the paper. The models are built based on the Dirac–Born–Infeld (DBI) action modified for open strings with their endpoints on a Dp-brane or brane–anti-brane at a tachyonic vacuum.
Dynamics analysis and Hamilton energy control of a class of Filippov neuron model
Authors: Ren Yan-Lan , Zhang Li , An Xin-Lei , Qiao Shuai
Published: January 2023

Electromagnetic induction plays a key role in regulating the electrical activity, excitability, and bistable structure of neurons. In this paper, a discontinuous control strategy with membrane potential as the threshold is introduced to the HR neuron model under the influence of electromagnetic field (EMFN model), and then we establish a Filipov EMFN neuron model to realize the regulation effect of electromagnetic field on the neuron system. Specific work of this paper reads as follows: first, the existence and stability of equilibrium points of two subsystems are analyzed by using MatCont software; second, the bistable region and its internal mechanism are discussed in detail by two-parameter bifurcation analysis; third, the mechanism of bistability and a series of complex sliding mode dynamics including sliding segment and sliding bifurcations are further revealed with the help of the fast–slow variable dissection method; finally, based on Hamilton energy, the regulation of threshold on chaotic discharge in the Filippov EMFN neuron model is explored. The numerical simulation results show that the EMFN neuron model can produce the corresponding sliding limit cycle and sliding bursting behaviors under the influence of the threshold control strategy, meanwhile, the chaotic behavior of the new system can be controlled effectively within a certain range. The results provide ideas for controlling the effects of electromagnetic fields on the biological neuronal system and exploring the regulation mechanism of neurological diseases.
A 10-Bit 20 Channel LCD Column Driver Using Compact DAC
Authors: Agarwal Neeraj , Agarwal Neeru , Lu Chih-Wen
Published: January 2023

A 20-channel liquid crystal display (LCD) driver architecture is implemented with [Formula: see text]m CMOS technology. This work presents a novel design of 10-bit compact and high-resolution two-stage DAC to improve the linearity and uniformity of each channel performance. A complete column driver, including a compact DAC, low power buffer, global R-string and multiplexing circuit design, is implemented, and the layout of this 20-channel, 10-bit LCD driver is generated using [Formula: see text]m CMOS technology. All the circuit blocks of the proposed LCD column driver were simulated using the EDA tool HSPICE and layout generation by Laker. This work also realizes a high-performance class AB operational amplifier with a gain of 140[Formula: see text]dB for the proposed LCD driver. The 10-bit compact LCD driver has a 1.4 mV LSB and an output voltage of 1.7 V is achieved for the input range of 0.25–1.7[Formula: see text]V. The compact DAC voltage selector with decoder in this design uses fewer switches in comparison to conventional tree-type RDAC, occupying a smaller chip area with fast response. The proposed design is sufficiently robust for high-color depth and resolution LCD driver applications. The experimental results exhibit maximum differential nonlinearity (DNL) and integral nonlinearity (INL) of 0.065 LSB and −0.12 LSB, respectively. The one channel area is [Formula: see text]m and the settling time is [Formula: see text]s for the [Formula: see text] and 20[Formula: see text]pF driving load.
FURTHER ON OPIAL TYPE INTEGRAL INEQUALITIES FOR SUPERQUADRATIC FUNCTIONS
Authors: ZHANG XIUJUN , FARID GHULAM , BIBI AYESHA , NONLAOPON KAMSING , YAN TAO
Published: January 2023

The following inequality [Formula: see text] is well known in the literature as Opial’s inequality [Z. Opial, Sur une inégalité, Polon. Math. 8 (1960) 29–32], it had/has been studied extensively since its appearance. This paper investigates some of its generalizations in the prospect of generalized integral operators. From huge literature on this inequality, the results for superquadratic functions are considered and further analyzed for some integral operators. Several inequalities have been deduced for fractional integral operators by analyzing particular kernels.
EFFECT OF SILVER NANOPARTICLES ON THE OPTICAL REFLECTANCE SPECTRA OF Ag/Ag2O COMPOSITES SYNTHESIZED BY OXYGEN PLASMA TREATMENT OF SILVER THIN FILMS
Authors: KAYED KAMAL , ISSA MAYADA
Published: January 2023

In this work, we present the results of a unique study that aims to detect the structural effects on the plasma edges in optical reflectance spectra of Ag/Ag2O composites synthesized by treating silver thin films manufactured by thermal evaporation method with oxygen plasma afterglow. The results showed that, each of the optical reflectance spectra contains two plasma edges, the first ([Formula: see text] belongs to the surface plasmons of the individual silver nanoparticles, and the second ([Formula: see text] belongs to the larger silver nanoparticles. In addition, we found that the positions of the plasma edges are linearly related to the positions of the optical absorption peaks, except for high and low oxidation rates cases.
Isolation Effect of P-Wave By Double-Layer Wave Impeding Barrier in Unsaturated Foundations
Authors: Ma Qiang , Jiang Ye
Published: January 2023

Wave impeding block (WIB) barriers are often used to reduce vibration from different sources, but traditional vibration isolation of WIB has been limited to homogeneous materials and single-phase elastic or two-phase saturated foundations by many researchers. In fact, soils in nature are usually tri-phase unsaturated materials, and the propagation characteristics of elastic waves in unsaturated medium are completely different from those in single-phase elastic medium or two-phase saturated porous medium. In addition, the conventional WIB barrier has better vibration isolation only at low frequencies. Therefore, this paper improves the vibration isolation of the WIB by double-layer WIB with the same thickness on the basis of traditional WIB. Based on the wave theory of unsaturated porous media and elastic media, and according to the Helmholtz principle, we can obtain the solution of surface vertical displacement after setting double-layer WIB in unsaturated foundation, and then the isolation effect of double-layer WIB in unsaturated foundation under [Formula: see text]-wave incidence is investigated. The wave impedance ratio at the interface between WIB and unsaturated soil and wave impedance ratio at the interfaces among the layers of WIB is first analyzed on the vibration isolation effect of double-layer WIB, and the wave impedance ratio corresponding to the optimal vibration isolation effect of WIB barrier is achieved. Then the key factors such as incidence angle, incidence frequency, saturation, thickness, and burial depth of the double-layer WIB are evaluated on its vibration isolation properties. Finally, the isolation effects of single-layer homogeneous WIB and double-layer non-homogeneous WIB with the same thickness are compared. For the same thickness isolation barrier, the vibration isolation efficiency of double-layer WIB is 42.73% higher than single-layer at the incidence angle of [Formula: see text]–[Formula: see text]. The double-layer WIB has better isolation effect at low, medium and high frequencies than single-layer WIB.
Function algebras on the n-dimensional quantum complex space
Authors: Cohen Ismael , Wagner Elmar
Published: January 2023

This paper introduces a (universal) C*-algebra of continuous functions vanishing at infinity on the [Formula: see text]-dimensional quantum complex space. To this end, the well-behaved Hilbert space representations of the defining relations are classified. Then these representations are realized by multiplication operators on an [Formula: see text]-space. The C*-algebra of continuous functions vanishing at infinity is defined by considering an *-algebra such that its classical counterpart separates the points of the [Formula: see text]-dimensional complex space and by taking the operator norm closure of a universal representation of this algebra.
Quasinormal modes and phase structure of regular AdS Einstein–Gauss–Bonnet black holes
Authors: Myrzakulov Yerlan , Myrzakulov Kairat , Upadhyay Sudhaker , Singh Dharm Veer
Published: January 2023

In this paper, we present an exact regular black hole solution in Einstein–Gauss–Bonnet coupled with nonlinear matter fields. It is a generalization of a regular Einstein–Gauss–Bonnet black hole in [Formula: see text] [Formula: see text] spacetime. The causal structure of the obtained solution identifies with Boulware–Deser black hole solution, except for the curvature singularity at the center. It incorporates the Boulware–Deser black holes in the absence of deviation parameters. We also study the thermodynamic properties of the solution that satisfies a modified first law of thermodynamics. Furthermore, we discuss the stability of the obtained black hole solution and, in this regard, a double phase transition occurs. Within this context, we find that phase transition exists at the point where the heat capacity diverges and, incidentally, the temperature attains the maximum value. We discuss the fluid nature of the black hole also exhibiting critical points. The quasinormal modes of the black hole solution and their dependencies on Gauss–Bonnet coupling and deviation parameters are also analyzed in terms of null geodesics.
Darboux transformation and soliton solutions of the nonlocal Heisenberg spin system with self-consistent potential
Authors: Yang Qianqian , Li Chuanzhong
Published: January 2023

In this paper, we investigate non-locality properties of the generalized Heisenberg spin system in the presence of self-consistent potential (called the M-XCIX system) according to the nonlocal gauge equivalence between it and the nonlocal nonlinear Schrödinger and the Maxwell–Bloch (NLS-MB) system. Then we construct a Darboux transformation for the nonlocal M-XCIX system and further generalize it to the matrix form of the [Formula: see text]-fold Darboux transformation of this system. Finally, in terms of a proper trivial seed solution, we derive one-soliton solutions and the computation formula of nonlocal two-soliton solutions and multi-soliton solution.
Chitosan, a Cationic Polymer-Loaded CuS:Ni Nanoparticles Well Suited for Pseudocapacitors, Optical Switching and Spintronic Devices
Authors: Karthika M. , Balu A. R. , Suganya M. , Chitra Devi S. , Sriramraj M. , Devendran K. , Vinitha G. , Delci Z. , Balamurugan S.
Published: January 2023

Chitosan, a cationic polymer, is loaded on Ni-doped copper monosulfide (CuS) NPs with optimal Ni doping concentration, and electrochemical, third-order nonlinear, magnetic and antibacterial characteristics of chitosan unloaded and loaded CuS:Ni nanoparticles are compared. The crystallite size of pure CuS increased with Ni doping and the 10[Formula: see text]wt.% Ni-doped CuS NPs exhibit a maximum crystallite size of 41[Formula: see text]nm. The presence of Ni in the doped samples was acknowledged by the existence of Ni 2p[Formula: see text] and Ni 2p[Formula: see text] peaks at binding energies 851[Formula: see text]eV and 873.1[Formula: see text]eV, respectively from the XPS spectrum. Optical reflectance decreased with Ni doping and the optical band gap varied from 2.56[Formula: see text]eV to 2.4[Formula: see text]eV. Specific capacitance increased with Ni doping. Diamagnetic nature of CuS changed to ferromagnetic with Ni doping. The 10[Formula: see text]wt.% Ni-doped CuS exhibits a high third-order nonlinear absorption coefficient and susceptibility value. Bacterial growth inhibition nature of CuS improved with Ni doping. Among the doped samples, the 10[Formula: see text]wt.% Ni-doped sample exhibits improved electrochemical, third-order nonlinear, magnetic and antibacterial properties. Keeping this as the optimized Ni concentration, chitosan was loaded. Chitosan-loaded samples exhibited a reduction in crystallite size and an increase in band gap. A high specific capacitance of 96[Formula: see text]F/g was realized for the chitosan-loaded sample. Saturation magnetization of 10[Formula: see text]wt.% CuS:Ni decreased with chitosan loading.
A Survey on Cross-chain Technologies
Authors: Han Panpan , Yan Zheng , Ding Wenxiu , Fei Shufan , Wan Zhiguo
Published: January 2023

Blockchain has attracted more and more attention of academia, industry, and government in recent decades. Different usage demands have inspired various blockchain designs, forming different blockchain systems, which leads to information islands. Many cross-chain technologies have been proposed to link different blockchains together and expand the utility of blockchain. Nevertheless, the cross-chain technology is still in its infancy, which faces many problems that retard its wide application, for example, the issues related to security, privacy, and effectiveness. In order to further investigate cross-chain technologies, it is essential to understand its current state of arts. Although there are some surveys about cross-chain technologies driven by specific demands, the literature still lacks a comprehensive survey focusing on security, privacy, and effectiveness of cross-chain technologies. In this paper, we provide a review on existing cross-chain technologies based on a comprehensive set of criteria on security, privacy, and other performance. We first propose a blockchain interoperability architecture for the purpose of analyzing potential threats and problems regarding security, privacy, and effectiveness. We then summarize a set of criteria regarding these quality attributes. Next, we comprehensively review the representative works on cross-chain technologies according to a taxonomy based on applied types of techniques and cross-chain purposes. In each work review, we provide a serious discussion on its pros and cons by employing our proposed criteria. Finally, based on our review and analysis, we figure out a number of open issues and step ahead to direct future research directions on cross-chain technologies.
Report on the 2nd Linked Archives International Workshop (LinkedArchives 2022) at TPDL 2022
Authors: Lopes Carla Teixeira , Ribeiro Cristina , Niccolucci Franco , Poveda-Villalón María , Freire Nuno
Published: January 2023

The 2nd edition of the International Workshop on Archives and Linked Data ran in conjunction with the 26th International Conference on Theory and Practice of Digital Libraries (TPDL 2022). TPDL 2022 was an in-person event in Padua with an online-only registration for non-speakers. Archives, the guardians of large volumes of historical and current information, are showing a growing interest in linked data and semantic web technologies. These technologies can be used to link archives' information with data from other cultural heritage institutions and more informal sources. In a world of linked data, users can access richer interfaces where the archival records are available in their context, with explicit metadata. The workshop gathered about 20 researchers and specialists engaged in initiatives crossing linked data technologies, archives, and cultural heritage in general, discussing advances and challenges in this area. The workshop was a successful event, with active participation in the discussions that followed the presentations. The participants found the workshop interesting (40%) or extremely interesting (60%), and everyone who answered a post-workshop survey would be interested in another edition of the workshop.

Date:
20 September, 2022.

Website:
https://linkedarchives.inesctec.pt/.
Report on the 1st Workshop on Human-in-the-Loop Data Curation (HIL-DC 2022) at CIKM 2022
Authors: Demartini Gianluca , Yang Jie , Sadiq Shazia
Published: January 2023

We report on the First Workshop on Human-in-the-loop Data Curation (HIL-DC), which was co-located with the ACM International Conference on Information and Knowledge Management (CIKM) 2022. Data curation, which may include annotation, cleaning, transformation, integration, etc., is a critical step to provide adequate assurances on the quality of analytics and machine learning results. Current approaches include manual, automated, and hybrid human-machine methods to data curation. However, this topic remains relatively unstudied, so our main aim for organizing this workshop was to bring together a group of people from both industry and academia with an interest in the topic, in order to arrive at a shared roadmap for the future. Through a program that included two keynotes, seven peer-reviewed papers, and six lightening talks, we have made initial steps towards a common understanding and shared research agenda for this timely and important topic.

Date:
21 October, 2022.

Website:
https://hilworkshops.github.io/hil-dc2022/.
Report on the 2nd International Workshop on Transforms in Behavioral and Affective Computing (THECOG 2022) at CIKM 2022
Authors: Drakopoulos Georgios , Kafeza Eleanna
Published: January 2023

Human decision making is central in many functions across a broad spectrum of fields including marketing, investments and smart contracts, digital health, political campaigns, logistics, and strategic management to name only a few. Computational behavioral science, the focus of the second consecutive iteration of the international workshop on transforms in behavioral and affective computing (THECOG) which was held in conjunction with CIKM 2022, not only studies the various psychological, cultural, and social factors contributing to decision making besides reasoning, but it also seeks to construct robust, scalable, and efficient computational models imitating or extending decision making processes. This year the keynote speech focused on affective robotics and their expected advantages in substantially improving the quality of human life. Moreover, the accepted papers had a considerable topical variety covering among others smart cities, speech emotion recognition, deepfake discovery, and how smart coupons may influence online consumer behavior. THECOG 2022 for a second continuous year was a central meeting point where new results were presented.

Date:
21 October, 2022.

Website:
https://www.cikm2022.org/workshops.
Potential role of endoplasmic reticulum stress in broiler woody breast myopathy
Authors: Greene Elizabeth S. , Maynard Clay , Mullenix Garrett , Bedford Mike , Dridi Sami
Published: January 2023

Although broiler (meat-type) chickens are one of the most efficient protein sources that supports the livelihoods and food security of billions of people worldwide, they are facing several challenges. Due to its unknown etiology and heavy economic impact, woody breast (WB) myopathy is one of the most challenging problems facing the poultry industry, and for which there is no effective solution. Here, using a primary chicken myotube culture model, we show that hypoxia and endoplasmic reticulum (ER) stress are an integral component of the etiology of the myopathy. Multiple components of the ER stress response are significantly upregulated in WB as compared with normal muscle, and this response was mimicked by hypoxic conditions in chicken primary myotube culture. In addition, apoptotic pathways were activated as indicated by increases in active caspase 3 protein levels in both WB-affected tissues and hypoxic myotube culture, and caspase 3 activity and apoptosis in hypoxic myotube culture. Finally, as a phenotypic hallmark of WB is enhanced fibrosis and increased collagen aggregation, here, we show that hypoxic conditions increase collagen 1A1 and 1A2 gene expression, as well as collagen 1 protein levels in primary myotubes. These effects were partially reversed by tauroursodeoxycholic acid (TUDCA), an ER-stress inhibitor, in myotube culture. Taken together, these findings indicate that hypoxia and ER stress are present in WB, hypoxia can upregulate the cell death arm of the unfolded protein response (UPR) and lead to collagen production in a culture model of WB. This opens new vistas for potential mechanistic targets for future effective interventions to mitigate this myopathy.
Mu-opioid receptor alleviated ferroptosis in hepatic ischemia-reperfusion injury via the HIF-1α/KCNQ1OT1 axis
Authors: Zou Shuangfa , Sun Huiping , Peng Yanhua , Liang Canxin , Zheng Chumei , Wang Lijuan , Yang Jinfeng
Published: January 2023

Ferroptosis is the ideal therapeutic target for hepatic ischemia and reperfusion injury (HIRI). The μ opioid receptor (MOR) is associated with ferroptosis in HIRI. We aimed to determine the ferroptosis-related therapeutic mechanism of MOR in HIRI. A model of HIRI was established in BALB/c mice. Primary hepatocytes isolated from mice were stimulated by hypoxia/reoxygenation (H/R). Changes in histopathology were determined by H&E staining. Alterations in ferroptosis were evaluated by malondialdehyde (MDA), iron, glutathione (GSH), ACSL4, GPX4, and mitochondrial morphology. ALT and AST were used to determine hepatic function. First, we found that hepatic ischemia/reperfusion (I/R) induced the destruction of hepatic tissue structure and dead hepatocytes and determined that ferroptosis occurred in vivo and in vitro. During HIRI, the expression levels of HIF-1α and KCNQ1OT1 were significantly upregulated. We demonstrated that sufentanil improved the damage in the liver and hepatocytes undergoing I/R. Importantly, sufentanil inhibited ferroptosis in HIRI. In addition, sufentanil downregulated the expression levels of HIF-1α and KCNQ1OT1 in HIRI. Increases in HIF-1α and KCNQ1OT1 reversed the role of sufentanil in ferroptosis and HIRI. Subsequently, we determined that HIF-1α could activate the transcription of KCNQ1OT1 by binding to its promoter. In addition, KCNQ1OT1 was demonstrated to enhance ACSL4 stability by interacting with SRSF1. Finally, we observed that KCNQ1OT1 downregulation protected hepatocytes from hepatic I/R and inhibited ferroptosis. KCNQ1OT1 upregulation aggravated ferroptosis and hepatic injury during I/R. However, decreases in ACSL4 and SRSF1 reversed the harmful role of KCNQ1OT1 upregulation in HIRI. MOR alleviated ferroptosis in HIRI via the HIF-1α/ KCNQ1OT1 axis.
Normal muscle fiber type distribution is recapitulated in aged ephrin-A3−/− mice that previously lacked most slow myofibers
Authors: Arpke Robert W. , Moritz Timothy C. , Hahn Kevin L. , Stark Danny A. , Villalón Eric , Lorson Christian L. , Cornelison DDW
Published: January 2023

Individual limb muscles have characteristic representation and spatial distribution of muscle fiber types (one slow and up to three fast isoforms) appropriate to their unique anatomical location and function. This distribution can be altered by physiological stimuli such as training (i.e., for increased endurance or force) or pathological conditions such as aging. Our group previously showed that ephrin-A3 is expressed only on slow myofibers, and that adult mice lacking ephrin-A3 have dramatically reduced numbers of slow myofibers due to postnatal innervation of previously slow myofibers by fast motor neurons. In this study, fiber type composition of hindlimb muscles of aged and denervated/reinnervated C57BL/6 and ephrin-A3−/− mice was analyzed to determine whether the loss of slow myofibers persists across the lifespan. Surprisingly, fiber-type composition of ephrin-A3−/− mouse muscles at two years of age was nearly indistinguishable from age-matched C57BL/6 mice. After challenge with nerve crush, the percentage of IIa and I/IIa hybrid myofibers increased significantly in aged ephrin-A3−/− mice. While EphA8, the receptor for ephrin-A3, is present at all neuromuscular junctions (NMJs) on fast fibers in 3–6 mo old C57BL/6 and ephrin-A3−/− mice, this exclusive localization is lost with aging, with EphA8 expression now found on a subset of NMJs on some slow muscle fibers. This return to appropriate fiber-type distribution given time and under use reinforces the role of activity in determining fiber-type representation and suggests that, rather than being a passive baseline, the developmentally and evolutionarily selected fiber type pattern may instead be actively reinforced by daily living.
Hypo-osmolarity induces apoptosis resistance via TRPV2-mediated AKT-Bcl-2 pathway
Authors: Urushima Hayato , Matsubara Tsutomu , Miyakoshi Masaaki , Kimura Shioko , Yuasa Hideto , Yoshizato Katsutoshi , Ikeda Kazuo
Published: January 2023

Our study first revealed that hypo-osmolarity-induced mechanotransduction enhanced calcium-mediated AKT signaling via TRPV2 activation, resulting in contributing to apoptosis resistance. The finding indicates a possible view that liver cirrhosis-induced hyponatremia promotes hepatocellular carcinogenesis.