bluuebunny/crossref_metadata_2025 huggingface dataset:
PERANCANGAN SISTEM INFORMASI PERPUSTAKAAN BERBASIS WEB DI SMK PLUS PRATAMA ADI BANDUNG
Authors: Pasaribu Johni S.
Published: September 2021

The rapid development of the computer world that brings every individual or group of people will use information and communication technology in every activity. Likewise in the world of education, including libraries that utilize information and communication technology in managing the process of borrowing and returning library books. The benefits of making a web-based library information system include being able to save time where there is no need for manual recording, making it easier to find book data or library members, making it easier in making book loan reports and other reports and other benefits. The research method used is Research and Development (R&D). The making of software is done by a waterfall model consisting of: (1) needs analysis, (2) design, (3) implementation, and (4) testing. Then UML visual modeling is used which is the standardization of modeling language for object-oriented software development. The expected results of this study produce a web-based library information system using the YII Framework with MVC (Model View Controller) method in SMK Plus Pratama Adi Bandung that can solve existing problems. The formulation of the problem of this research is how to build a library information system in SMK Plus Pratama Adi Bandung so that it can present accurate and efficient information. The purpose of this research is to produce a library information system.
Perencanaan Strategis Penyebaran Tenaga Penjualan Menggunakan Program Dinamik (Studi Kasus: Sentra Kerupuk Lempeng “ABC”)
Authors: Asnawi Noordin
Published: September 2021

Abstract— In making a sale of a product offline usually requires a sales force to market the product to various regions. But in the utilization of sales force, sometimes there are still many who do not plan how to deploy / allocate existing sales force to obtain optimal / maximum and efficient results. Of the various ways, one of the choices of ways that can be used is dynamic programming / programming which is a solution approach, where the method can be used to help provide planning in distributing sales force deployments to several regions, so simply this dynamic program can provide solutions in the problem of distributing the sales force that is done manually by by detailing the problem and solving it in stages. In the case of the distribution of sales force from the "ABC" Plate Crackers Center to several sales areas, the results are obtained for the allocation of sales force to 3 regions (sub-districts) with the result of 0 salespeople for the region (sub-district) 2, 0 salespeople for the region (sub-district) 3, and 3 salespeople for the region (sub-district) 1 in order to obtain maximum / optimal sales results. Keywords—: Sales force; Dynamic Program; Plate crackers.
Rancang Bangun Pemantau Daerah Endemik Malaria Berbasis IoT Menggunakan Metode Profile Matching
Authors: Sahtyawan Rama , Sudarmana Landung
Published: September 2021

Abstract— Malaria is an endemic disease transmitted by Anopheles mosquitoes, which causes increased morbidity and mortality (morbidity and mortality), maternal and child health disorders, intelligence, labor force productivity, and detrimental to tourism. From these problems, a tool was developed to monitor endemic malaria areas in real-time by using temperature and humidity data for an area. Then analyzed using the profile matching method to calculate the weight/score gap in temperature and humidity conditions using interpolation, the data will be sent by the DHT 11 sensor found on NodeMcu. The application used to find out in real-time using the Blynk application as an internet of things board with a Wifi connection for the next step NodeMcu requires coding using the Arduino IDE program, for testing the location system used consists of 5 locations namely: L1 = Jl.Magelang, L2 = Jl.Maguwoharjo, L3 = Jl.Babarsari, L4 = Jl.Wates km9, L5 = Jl.Ali times km 8. Obtained temperature and humidity data (L1 = 36.30), (L2 = 18.32), (L3 = 23.45), (L4 = 38.33), (L5 = 35.53), then the gap weight calculation using the interpolation method obtained temperature and humidity data (L1 = 3,800; 3,974), (L2 = 4,600; 4,179), (L3 = 5,000; 5,000), (L4 = 3,400; 4,282), (L5 = 4,000; 5.00), the results obtained from rank 5 locations are malaria-endemic areas, rank 1 = L3-Babarsari, rank 2 = L5-Jl.Kaliurang km 8, rank 3 = L2-Jl.Maguwoharjo, rank 4 = L1-Jl.Magelang, rank 5 = L4-Jl.Wates. from the ranking data, the location must be prioritized L3-Babarsari. Keywords—: Malaria; DHT 11, NodeMCU; Profile Matching; Blynk.
Farmacoterapia da obesidade: fármacos disponíveis no Brasil e perfis de eficácia e segurança
Authors: Utta Kevellyn Bezerra , Pessoa Débora Luana Ribeiro
Published: September 2021

A farmacoterapia da obesidade está em constante atualização e desenvolvimento de novos produtos e propostas, sendo por vezes visto como uma opção controversa, necessitando criteriosa avaliação para sua utilização, observando critérios como condição clínica do paciente e características do fármaco a ser utilizado, fazendo-se necessário o conhecimento sobre seus perfis de ação e segurança relacionados ao seu uso. O objetivo foi identificar e sistematizar os dados mais recentes presentes da literatura sobre os principais fármacos utilizados no tratamento da obesidade no Brasil e suas reações adversas. Foi realizada revisão integrativa de artigos publicados em português, inglês e espanhol, disponíveis na íntegra nas bases LILACS, BIREME (BVS) e MedLine. Utilizou-se os descritores “terapia medicamentosa” AND “obesidade” para a base LILACS, “terapia farmacológica” AND “obesidade” para a base Medline/Pubmed e “fármacos” AND “antiobesidade” para a base BIREME/BVS para artigos publicados no período de 2015 a 2020, sendo selecionados e analisados 15 estudos. Na base LILACs, MEDLINE/PUBMED e BIREME/BVS foram obtidos respectivamente 16, 49 e 305 artigos como resultados. Ao final de todas as análises e critérios de seleção, foram inclusos 15 artigos no presente estudo. A maioria dos medicamentos aprovados para o tratamento da obesidade no Brasil, demonstrou eficácia e segurança em ensaios clínicos. Foram observadas taxas semelhantes de eventos adversos entre orlistate, liraglutida e lorcaserina, com liraglutida possuindo maiores eventos gastrointestinais do grupo. Dentre as possibilidades de novos fármacos para a obesidade que apresentaram melhores resultados de perda de peso, foram exenatida e melatonina, com eficácia demonstrada em ensaios clínicos.
A inovação tecnológica atrelada ao estímulo sustentável: uma análise no Centro Tecnológico do Porto Digital em Pernambuco - Brasil
Authors: Maia Diwlay Cardoso , Alves Elaine Cristina , Rolim Stela Maria Torres de Melo , Silva Andrea Karla Pereira da , Melo Fagner José Coutinho de , Fernandes Mucio Luiz Banja
Published: September 2021

O estudo tem por objetivo compreender como o Centro Tecnológico do Porto Digital na cidade do Recife contribui com o desenvolvimento sustentável, econômico e social em Pernambuco, considerando as iniciativas sustentáveis estimuladas entre as empresas vinculadas ao Centro. Para identificar os projetos desenvolvidos, assim como os resultados obtidos pelas ações, foram realizadas pesquisas bibliográficas e análises documentais, provenientes de publicações acadêmicas, produções de órgãos públicos, reportagens e informações divulgadas no site do Porto Digital. possibilitaram a observação das práticas sustentáveis que são incentivadas ou realizadas e identificaram-se benefícios quanto à preservação do meio ambiente, à expansão da economia e à qualidade de vida na sociedade. Considerando que as iniciativas geradas pelo Porto Digital ainda estão dispersas na literatura e que tal fator dificulta a análise por interessados, empresários, estudantes e pesquisadores, a análise apresentada visa contribuir com o campo bibliográfico, enfatizando a inovação tecnológica e o desenvolvimento sustentável.
Human milk: processing and conservation – a review
Authors: Castro Matheus Campos , Alves Eloize Silva , Saqueti Bruno Henrique Figueiredo , Souza Patrícia Magalhães , Manin Luciana Pelissari , Silveira Roberta da , Madrona Grasiele Scaramal , Santos Oscar Oliveira , Visentainer Jesui Vergilio
Published: September 2021

Human milk has a balance of nutrients and bioactive compounds, and it must be the exclusive food source during the first six months of the infant's life. In cases where the woman is unable to breastfeed, due to hypogalactia or pre-existing disease, the use of donated human milk, available in human milk banks, is recommended. Currently, in the human milk banks the processing applied for greater conservation is Holder pasteurization. Therefore, the objective of this work is to perform a search in the literature about new possible treatments to be applied to human milk, and its influence on its physical-chemical composition; and in this sense, the studied processes were: Holder pasteurization, lyophilization, spray-drying, high hydrostatic pressure, high temperature and short time, and short wave ultraviolet irradiation. For that, a search was performed in databases, and 126 articles were selected to carry out this review according to the keywords used. It was observed that the studied treatments can be applied for the processing and conservation of human milk, once it was applied in matrices with similar composition.
Biotecnologia vegetal 4.0: uma abordagem sobre “Speed Breeding”
Authors: João Amanda Aparecida , Ferreira Lucas Fantin Machado , Corrêa Pedro Henrique Florêncio , Luiz Rita de Cássia Portes , Oliveira Neto Sebastião Soares de
Published: September 2021

O aumento da população humana relacionado à demanda alimentar e o atual cenário de mudanças climáticas têm desafiado pesquisadores no mundo todo, tornando indispensável otimizar a obtenção de cultivares com alta produtividade, aliada a maior qualidade nutricional e maior resistência às condições abióticas e bióticas, priorizando a sustentabilidade e a preservação dos recursos naturais. Neste contexto, o melhoramento de plantas associado às técnicas de biotecnologia possibilita modificar geneticamente as plantas para o benefício humano, a fim de solucionar problemas e criar produtos que atendam as características agronômicas desejáveis, no entanto, o desenvolvimento de novas cultivares demanda um longo período para selecionar linhagens superiores com elevado desempenho agronômico. Para reduzir o ciclo em programas de melhoramento clássico, algumas técnicas estão sendo usadas e apresentam resultados promissores, uma delas é o Speed Breeding, que reduz o tempo de melhoramento e acelera a pesquisa, por meio da obtenção de novas gerações de forma rápida, através do uso de condições de luz e temperatura controladas para aumentar o crescimento das plantas, acelerando a busca por cultivares que atendam às necessidades dos produtores e consumidores.  Esse trabalho tem como objetivo apresentar, através de uma abordagem crítica, a metodologia Speed Breeding como ferramenta para acelerar os programas de melhoramento vegetal.
Análise clínica e radiográfica de uma pasta endodôntica à base de hidróxido de cálcio e Aloe vera: ensaio clínico randomizado
Authors: Cavalcante Larissa Cordeiro , Soares Isadora Mello Vilarinho , Carvalho Carmen Milena Rodrigues Siqueira
Published: September 2021

Esse ensaio clínico randomizado avaliou uma pasta medicamentosa intracanal à base de Ca(OH)2 e Aloe vera em dentes necrosados com lesão periapical. Sessenta e quatro dentes, de 60 pacientes, foram divididos de acordo com a medicação intracanal utilizada: Controle (Ca(OH)2 e soro fisiológico), e experimental (Ca(OH)2 e Aloe vera). Foi realizado instrumentação endodôntica e inserção da medicação intracanal de acordo com o grupo. Após 15 dias, os dentes foram obturados e restaurados. A sintomatologia pós-operatória foi avaliada seguindo uma escala de dor. A avaliação clínica e radiográfica foi realizada aos três, seis e nove meses pós-tratamento. Os tratamentos foram classificados em sucesso (os que apresentaram cicatrização parcial ou total) e insucesso. Para análise estatística de dor pós-operatória entre grupos foi utilizado o teste Mann-Whitney. A análise intragrupo utilizou o teste de Friedmann. Para avaliação do sucesso do tratamento, utilizou-se o teste qui-quadrado. Considerou-se significativo p< 0,05. Quarenta e oito pacientes, sendo um dente em cada, concluíram o estudo. Os valores da dor pós-operatória nos tempos 04 e 24 horas para significativos para o grupo Aloe vera (p<0,001), sem diferença estatística entre os grupos (p=0,307) no tempo de 48 horas. Após os nove meses, as taxas de sucesso foram de 95,8% para o grupo experimental e 83,3% para o controle, sem diferença significativa (p=0,348). A pasta de Aloe vera e Ca(OH)2 proporcionou remissão da dor pós-operatória, sem alterações clínicas e radiográficas significativas. Acredita-se que o Aloe vera pode ser um veículo alternativo para o hidróxido de cálcio como medicação intracanal.
Evaluation of broiler dark house illumination systems, with and without thermal insulation
Authors: Pan Karison Ferreira , Siqueira Jair Antonio Cruz , Souza Samuel Nelson Melegari de , Tokura Luciene Kazue , Nogueira Carlos Eduardo Camargo , Dieter Jonathan , Caneppele Fernando de Lima
Published: September 2021

In the breeding of broiler house, the proper use of lighting systems has great influence on the welfare and the productivity of the birds. The objective was to evaluate two artificial lighting systems used in broiler house in terms of the allocative efficiency of luminance. One of the broiler house was closed with black raffia bag (dark house), without thermal insulation (NTI) and its lighting was composed of incandescent, compact fluorescent light (LFCs) and light emitting diode (LED) bulbs. The other broiler house was closed with extruded polystyrene panels (XPS) and thermally insulated (TI), and its lighting was composed of compact fluorescent lamps. The influence of external light of sun inside the broiler house was analyzed by means of exhaust holes and the degree of distribution of illumination through statistical analyzes and the study of the distribution uniformity coefficient (DUC). Contour maps were prepared showing the degree of internal luminance distribution for each broiler house, specifically in the area that did not suffer interference from external natural sunlight. The results showed that natural lighting influenced the internal lighting across the last 18 meters at the end of the broiler house and there was a more homogeneous lighting in the broiler house TI.
Submandibular approach for orotracheal intubation in Oral and Maxillofacial Surgery and Traumatology
Authors: Puricelli Edela , Ponzoni Deise
Published: September 2021

Introduction: Submandibular tracheal intubation is a technique that can be applied in Oral and Maxillofacial Surgery and Traumatology, as well as other surgical specialties. Its main advantages are helping in the surgical manipulation of the middle facial skeleton and jaw and allowing the intraoperative control of dental occlusion. The technique is an alternative to elective tracheostomy. Objective and case report: The article presents the treatment of an adult patient, with sequelae of multiple fractures in the face due to a car accident, with endotracheal intubation using submandibular approach. Final considerations: In large surgical manipulations of the face, the submandibular approach for tracheal intubation allows a faster, facilitated anatomical access with a lower risk of damage to adjacent structures when compared to other pathways. It also guarantees excellent cervical mobility, the possibility of wide manipulation and the use of occlusion as a guide for surgical intervention.
Helmintofauna de Paroaria dominicana (Linnaeus, 1758) oriundos do tráfico de animais silvestres
Authors: Santos Inamara Silva , Tavares Karoline dos Santos , Teixeira Rayana Emanuelle Rocha , Oliveira Marilene Souza , Prado Isabela Sousa , Antonio Edma Santos de , Sodré Neto Antônio Iderval , Anjos Matheus Santos dos , Tomazi Laize , Nishiyama Patrícia Belini , Silva Márcio Borba da , Fraga Ricardo Evangelista
Published: September 2021

O tráfico de animais silvestres é um problema com repercussões ecológicas e sociais. Além de causar o declínio de diversas populações naturais, esta prática tem consequências diretas sobre os indivíduos capturados, como quadros de imunossupressão que podem resultar na manifestação de variados patógenos. No Brasil, o tráfico de aves silvestres se destaca como uma das modalidades mais populares desta prática. As espécies mais procuradas usualmente possuem atrativos estéticos ou sonoros, como muitos exemplares Passeriformes. O cardeal-do-nordeste (Paroaria dominicana) é uma destas espécies, chegando a ser considerada uma das mais traficadas do país. Neste trabalho, analisamos 26 exemplares de Paroaria dominicana provenientes de uma ação de resgate executada pelo IBAMA. Foram realizadas técnicas de necropsia e sedimentação espontânea para verificar a presença de helmintos e ovos nos órgãos dos exemplares analisados, bem como pesagem e mensuração dos cadáveres. Encontramos a presença de espécies de nematódeos em 05 exemplares; todos pertencentes ao gênero Diplotriaena, incluindo a espécie Diplotriaena delirae, registrada pela primeira vez na helmintofauna de Paroaria. dominicana. Observamos a presença de ovos característicos do gênero Diplotriaena e Heterakis, este último também inédito a helmintofauna de Paroaria dominicana até o presente trabalho. A presença de novas espécies na helmintofauna de Paroaria dominicana pode estar associada ao contato direto com outras espécies silvestres durante a captura e o transporte ilegal, bem como as condições sanitárias associadas a essas etapas do tráfico de aves.
Políticas Públicas e a Primeiríssima Infância: avanços, limites e desafios
Authors: Araújo Cintia Maria Magalhães Oliveira de , Silva Állif Ramon Lima Felix da , Martins Ridalva Dias Félix , Macedo Flávia Lavínia de Carvalho , Silva Camila Tahis dos Santos , Bezerra Irene Cristina de Matos
Published: September 2021

Objetivo: refletir e caracterizar as principais políticas públicas e programas de saúde e seus impactos no crescimento e desenvolvimento na primeiríssima infância. Método: Trata-se de uma revisão crítica oriunda do estudo e debates de políticas de saúde voltadas à primeiríssima infância.  Resultados e Discussão: Ao realizarmos um traçado histórico nas políticas públicas em saúde na primeiríssima infância, podemos destacar avanços em vários aspectos, seja na criação, ampliação ou melhoria de políticas e abordagens. Conclusão: É evidente a preocupação e as tentativas em oferecer políticas direcionadas à primeiríssima infância com vistas ao crescimento e desenvolvimento adequados embora a situação de risco e vulnerabilidade das crianças brasileiras esteja em total conformidade com as desigualdades sociais, econômicas e de acesso aos serviços dificultando a implementação desde arcabouço legal e tornando-o insuficiente.
Applicability of Euphorbia milii var splendens latex in the control of Biomphalaria tenagophila
Authors: Coêlho Matheus Diniz Gonçalves , Esteves Cristiane de Carvalho , Bastos Carolina Aparecida , Melo Aline Fátima de , Maciel Lucas Tobias Rodrigues
Published: September 2021

The present work aimed to evaluate in vitro the molluscicidal activity and latex toxicity of Euphorbia milii var. splendens (Bojer ex Hook) Ursch & Leandri for the control of mollusks of the species Biomphalaria tenagophila. Specimens of E. milii var. splendens cultivated in the rural region of Pindamonhangaba were selected, from which latex was obtained by the transverse incision of the aerial parts. For the molluscicide test, adult mollusks of the species B. tenagophila were separated into groups of 10 and submitted to latex immersion at concentrations of 2.5 ppm, 1.25 ppm, 0.625 ppm, and 0.3125 ppm for 24 hours. In parallel, the toxicity of latex at a concentration of 0.3125 ppm was determined by testing with Artemia salina (mortality assessment) and using the Allium cepa test (determination of growth inhibition, amount, and weight of roots). It was observed an important molluscicidal activity of E. milii var. splendens latex at the various concentrations evaluated. In addition, it was also possible to observe moderate toxicity against A. salina nauplii and in the toxicity test with A. cepa. This demonstrates the potential of using latex from E. milii var. splendens to control populations of B. tenagophila species, not only for the observed molluscicidal activity but also for the moderate mortality of A. salina nauplii, whereas in the A. cepa test no change was observed in the parameters evaluated in relation to the control group, demonstrating safety for use in the environment.
Serviço aeromédico em aeronaves de asas rotativas: realidade e perspectiva profissional
Authors: Nascimento Keyla Cristiane do , Moreira André Ricardo , Batista Euseli de Assis , Dutra Bárbara Duarte , Caminha Júnior Alexandre dos Santos
Published: September 2021

Objetivo: compreender a realidade laboral e perspectivas dos profissionais que integram a equipe de atendimento aeromédico de Santa Catarina. Metodologia: Estudo exploratório, descritivo, com enfoque qualitativo.  Foram realizadas 17 entrevistas com profissionais que integram o serviço aeromédico de helicópteros em Santa Catarina (médicos, enfermeiros, tripulantes operacionais e pilotos de aeronave). Utilizou-se entrevista semiestruturada, transcritas e analisadas por meio de análise de conteúdo. Resultados: da análise de conteúdo temática emergiram quatro categorias: atitude e conhecimento como necessidades de trabalho; responsabilidades e desafios profissionais; atributos para o serviço aeromédico e circunstâncias expressivas na perspectiva profissional do atendimento aeromédico. As categorias refletem questões que estiveram presentes nos discursos, evidenciando a importância do conhecimento e da aptidão técnica para a estabilização do paciente de emergência na atividade aeromédica. Os desafios profissionais foram representados por imprevisibilidade de acionamentos, atendimento com locais de difícil acesso e condições climáticas desfavoráveis. Conclusão: o estudo possibilitou compreender a realidade e percepção que os profissionais do serviço aeromédico possuem a respeito do trabalho que realizam. Enquanto modalidade de atendimento de emergências, exige múltiplas competências dos profissionais envolvidos, demonstrando a importância da capacidade técnica e cognitiva para a estabilização clínica do paciente, ancorado em conhecimento sobre fisiologia de voo, segurança de voo e navegabilidade; aliado a uma resiliência física. Percebe-se a predominância de um discurso hegemônico, com destaque para o trabalho em equipe, comunicação e confiança interprofissional.
Vínculos familiares dos idosos institucionalizados
Authors: Santos Thayse Camila Vitor dos , Ary Maria Luiza Morais Regis Bezerra , Calheiros David dos Santos
Published: September 2021

Introdução: O envelhecimento é uma etapa multidimensional na vida do ser humano, pois assume dimensões que ultrapassam o ciclo biológico, provocando consequências emocionais e sociais. Todas essas alterações geram impactos na vida do indivíduo que envelhece, principalmente no seio familiar a qual a família passa por mudanças e por vezes não consegue atender suas necessidades, tornando os idosos mais propícios ao isolamento social, bem como à internação em Instituições de Longa Permanência para Idosos (ILPIs), podendo haver rompimento de vínculos familiares. Objetivo: Descrever os vínculos familiares dos idosos de uma Instituição de Longa Permanência para Idosos de Maceió/AL. Metodologia: O presente estudo assume uma abordagem de caráter qualitativo, do tipo transversal e descritivo. Para a coleta de dados foi realizada uma entrevista norteada por um roteiro semiestruturado com 10 idosos residentes de uma ILPI de Maceió/AL. Para interpretação dos dados, utilizou-se a técnica de análise de conteúdo de Bardin, que permitiu identificar três categorias: “Relação familiar”, “Opção pela institucionalização” e “Aspectos que os levaram a residir na ILPI”. Resultados: Identificou-se que a relação familiar após o processo de institucionalização é relativamente fragilizada ou não a mantém, quanto à opção pela institucionalização, é de grande parte da família, verificou-se ainda que quanto aos aspectos que os levaram a residir na ILPI, a enfermidade apareceu como fator principal. Conclusão: Os resultados chamam atenção para a necessidade de maior suporte da família, pois o mesmo quando eficaz, traz consigo o bem-estar, sendo esse imprescindível para uma boa qualidade de vida dos idosos.
Compostos ativos de capim-cidreira (Cymbopogon citratus): uma revisão
Authors: Oliveira Carla Cristina Alves de , Santos Jâno Sousa
Published: September 2021

O presente estudo teve por objetivo apresentar um levantamento amplo e atual em relação aos compostos ativos do capim-cidreira (Cymbopogon citratus) e as funcionalidades por ele exercidas, tanto em in vitro quanto in vivo. Para tal foi realizada uma revisão da literatura, a qual reuniu o conhecimento científico sobre os aspectos das propriedades funcionais, do capim-cidreira. O levantamento teve como recorte temporal os últimos 10 anos (2011 a 2021). Foram utilizados os artigos em português e inglês. O levantamento bibliográfico apresenta os aspectos das plantas medicinais, sua utilização e seus compostos ativos. Apresenta as características do Cymbopogon citratus, seus compostos ativos e suas funcionalidades. Por meio das buscas verificou-se que esta planta possui compostos que lhe competem ação calmante, antifúngica, antimicrobiana, dentre outras. Concluiu-se assim que essas ações terapêuticas são produzidas, principalmente, pela presença do citral, componente em maior quantidade no óleo essencial desta erva, e por ter eficácia comprovada de seus benéficos e sendo este de fácil cultivo, tem-se nesta erva um fitoterápico de fácil acesso para população em geral, tanto para controle de moléstias humanas quanto para controle de pragas em animais.
Sagu de mandioca no Brasil: um paralelo entre a pesquisa de mercado e a rotulagem de alimentos
Authors: Silva-e-Silva Anna Carolina Alves Gomes da , Teodoro Anderson Junger , Santana Isabelle
Published: September 2021

A presença da mandioca e de seus derivados na alimentação brasileira é expressiva, exceto para o sagu de mandioca. Diante deste cenário, faltam estudos que revelem a extensão desse alimento no mercado brasileiro. O objetivo deste trabalho foi elucidar tal panorama a partir de uma pesquisa de mercado considerando a rotulagem e informações de publicidade, centrando-se na oferta on-line de sagus de mandioca no comércio brasileiro. As categorias sagu seco, mistura para sagu e sagu pronto para consumo foram avaliadas considerando: região de venda e preço, parâmetros de identidade e qualidade, lista de ingredientes, conteúdo líquido, tabela nutricional, porção e medidas caseiras, informações sobre glúten, lactose e alérgenos alimentares, embalagem e sites de venda ou oficiais. Foram considerados 81 produtos nacionais, sendo 75,3% (n=61) sagus secos, 19,7% (n=16) misturas para sagu e 5,0% (n=4) sagus prontos para consumo. Os sagus secos apresentaram inadequações em todas as categorias. As misturas para sagus foram adequadas nos parâmetros porção e medidas caseiras, informação sobre glúten e lactose. Os sagus prontos para consumo obtiveram erros sistemáticos por serem da mesma marca. Logo, foi possível aprofundar o panorama de produtos disponíveis e preços praticados, sendo o primeiro estudo realizado para o mercado brasileiro. Mesmo com uma quantidade relevante de sagus de mandioca no mercado, diversas marcas apresentam inadequação na rotulagem, o que comprova a necessidade de reformulação. Por fim, entende-se que os canais virtuais de comunicação podem ser mais utilizados para atrair a atenção dos consumidores para estes produtos, desde que haja linguagem técnica apropriada.
Intra-articular mesenchymal stem cell therapy on a joint capsule rupture in a horse – Case report
Authors: Cestari Heitor , Souza Joel Phillipe Costa e , Hussni Carlos Alberto , Rodrigues Celso Antonio , Watanabe Marcos Jun , Alves Ana Liz Garcia
Published: September 2021

Joint capsule rupture is an uncommon pathology that leads to intense pain, lameness and is related to the athletic performance impossibility of the animal. This pathology presents controversial therapeutic protocols in the equine clinic and surgery. Therefore, this study aimed to report the use of mesenchymal stem cells associated with arthroscopy and rehabilitation to improve the treatment of joint capsule rupture in equine. A three-year-old, male, Quarter Horse, presenting grade 5 lameness, with four months of evolution, was diagnosed with tibiotarsal joint capsule rupture. The patient underwent arthroscopic surgery, received an intra articular application of mesenchymal stem cells, and a rehabilitation protocol was performed. One year after the treatment and rehabilitation, the horse reestablished its athletic performance, thus indicating the success of the therapy using mesenchymal stem cells associated with surgical treatment and rehabilitation.
Northwest range shifts and shorter wintering period of an Arctic seabird in response to four decades of changing ocean climate
Authors: Patterson A , Gilchrist HG , Gaston A , Elliott KH
Published: September 2021

Climate change is altering the marine environment at a global scale, with some of the most dramatic changes occurring in Arctic regions. These changes may affect the distribution and migration patterns of marine species throughout the annual cycle. Species distribution models have provided detailed understanding of the responses of terrestrial species to climate changes, often based on observational data; biologging offers the opportunity to extend those models to migratory marine species that occur in marine environments where direct observation is difficult. We used species distribution modelling and tracking data to model past changes in the non-breeding distribution of thick-billed murres Uria lomvia from a colony in Hudson Bay, Canada, between 1982 and 2019. The predicted distribution of murres shifted during fall and winter. The largest shifts have occurred for fall migration, with range shits of 211 km west and 50 km north per decade, compared with a 29 km shift west per decade in winter. Regions of range expansions had larger declines in sea ice cover, smaller increases in sea surface temperature, and larger increases in air temperature than regions where the range was stable or declining. Murres migrate in and out of Hudson Bay as ice forms each fall and melts each spring. Habitat in Hudson Bay has become available later into the fall and earlier in the spring, such that habitat in Hudson Bay was available for 21 d longer in 2019 than in 1982. Clearly, marine climate is altering the distribution and annual cycle of migratory marine species that occur in areas with seasonal ice cover.
Juvenile growth deficit as an early alert of cockle Cerastoderma edule mortality
Authors: de Montaudouin X , Grimault S , Grandpierre M , Garenne A
Published: September 2021

In the population dynamics of bi-phasic marine invertebrates, the fitness of one stage in the life of a cohort affects that of the following stage. This effect makes the prediction of the fate of a cohort challenging. We conducted a 22 yr monthly survey of a population of cockles Cerastoderma edule focussed on the juvenile stage. Two types of years were distinguished in terms of cohort longevity: a low-mortality group (‘L’) and a high-mortality group (‘H’). The cockle shell lengths of the 0+ cohorts was higher in the L group, in August and September. A cohort could hereby confidently be assigned to the L or H group as soon as August. Maximum cockle abundance in the cohorts, parasite load, or date of recruitment did not discriminate the groups, while an early date for the peak of the 0+ cohort abundance could be related to the L group. The maximum air temperature and the chl a concentration in July were higher in the H group, whereas the minimum salinity during the month of September was slightly lower in the H group of years. Therefore, a juvenile shell length under a given threshold was identified as an early alert for a short lifespan of the cockle cohort. This long-term analysis contributes to the deeper understanding of the population dynamics of bi-phasic invertebrates. The success of juveniles is not solely related to the intensity of recruitment or mortality by predation, but could also be linked to their fitness, their growth rates appearing as a proxy.
Tracking movements of decapod crustaceans: a review of a half-century of telemetry-based studies
Authors: Florko KRN , Davidson ER , Lees KJ , Hammer LJ , Lavoie MF , Lennox RJ , Simard É , Archambault P , Auger-Méthé M , McKindsey CW , Whoriskey FG , Furey NB
Published: September 2021

Decapod crustaceans are ecologically and economically important invertebrates but are vulnerable to anthropogenic pressures and climate change. Understanding their spatial ecology is essential for their management and conservation, with telemetry emerging as a useful tool to quantify space-use and movements. Here, we synthesized the use of telemetry to study decapods among articles published from 1971 to 2019 (n = 102 studies), by taxonomic group of the study species, study location, objectives, number of animals tagged and their tag recovery rate, types (and trends) of telemetry used, and IUCN conservation status. These studies revealed insight into the behaviours and roles of decapods across habitats and geographic regions. The most common study species were crayfish and lobsters (41%, Astacidea), and these studies also had the highest number of individuals tagged per study (mean = 149 individuals). Most studies (86%) were conducted in the northern hemisphere. Acoustic tags were the most commonly used equipment (66% of studies) and were first employed in 1971, followed by radio-telemetry (mid-1990s), passive integrated transponders (mid-2000s), and data storage tags (late 2000s). Almost half (48%) of studies focused on species that had a conservation status of Least Concern, perhaps reflecting an applied science focus on animals of commercial interest rather than conservation importance. The positive allometric relationship between body length and movement rate (exponent = 0.86) demonstrates the type of broader ecological insight that combining these studies can provide. Tracking decapod movements will likely become increasingly important for managing fisheries, protecting sensitive species, and understanding invasion biology.
Plant breeding for resilient pastures
Authors: Caradus John , Bouton Joseph , Brummer Charles , Faville Marty , George Richard , Hume David , Inch Courtney , Kerr Graham , Montel Stephane , Stewart Alan , Woodfield Derek
Published: September 2021

Plant breeding has had, and continues to have, an important role in providing farmers with resilient pastures. Early breeding relied on improvement of ecotype populations and this was accelerated by crossing with selected introduced germplasm. The primary traits under selection have targeted speed of establishment, total and/or seasonal dry matter (DM) yield, nutritive value or feed quality, flowering time and reduced aftermath heading, disease resistance, persistence and seed yield. Continued improvement through plant breeding to meet environmental concerns and tolerances to both biotic and abiotic stresses will be achieved through ongoing plant introductions, exploiting heterosis, speed breeding, genomic selection, improvements in phenotyping, metabolomics, improved compatibility with beneficial microbes, and potentially the use of transgenic and gene editing technologies.
EV Translational Horizons as Viewed Across the Complex Landscape of Liquid Biopsies
Authors: Killingsworth Bryce , Welsh Joshua A. , Jones Jennifer C.
Published: September 2021

Extracellular Vesicle (EV)-based diagnostic and therapeutic tools are an area of intensive study and substantial promise, but EVs as liquid biopsies have advanced years ahead of EVs as therapeutic tools. EVs are emerging as a promising approach for detecting tumors, evaluating the molecular profiles of known disease, and monitoring treatment responses. Although correlative assays based on liquid biopsies are already having an impact on translational studies and clinical practice, much remains to be learned before these assays will be optimized for clinical correlations, functional biological studies, and therapeutic use. What follows is an overview of current evidence supporting the investigation and use of liquid biopsies, organized by specific liquid biopsy components available for analysis, along with a summary of what challenges must be overcome before these assays will provide functional biological insights into the pathogenesis and treatment of disease. The same challenges must also be overcome before it will be feasible to measure and monitor the dosing, distribution, pharmacokinetics, and delivery of EV therapeutics and their cargo in complex biofluids where EVs and circulate with and are co-isolated with a number of other nanoscale materials, including lipoproteins (LPPs), ribonucleoprotein complexes (RNPs), and cell free nucleic acids (cfNA).
Yap Regulates Müller Glia Reprogramming in Damaged Zebrafish Retinas
Authors: Lourenço Raquel , Brandão Ana S. , Borbinha Jorge , Gorgulho Rita , Jacinto António
Published: September 2021

Vertebrates such as zebrafish have the outstanding ability to fully regenerate their retina upon injury, while mammals, including humans, do not. In zebrafish, upon light-induced injury, photoreceptor regeneration is achieved through reprogramming of Müller glia cells, which proliferate and give rise to a self-renewing population of progenitors that migrate to the lesion site to differentiate into the new photoreceptors. The Hippo pathway effector YAP was recently implicated in the response to damage in the retina, but how this transcription coactivator is integrated into the signaling network regulating Müller glia reprogramming has not yet been explored. Here, we show that Yap is required in Müller glia to engage their response to a lesion by regulating their cell cycle reentry and progenitor cell formation, contributing to the differentiation of new photoreceptors. We propose that this regulation is accomplished through a lin28a–ascl1a-dependent mechanism, bona fide Müller glia-reprogramming factors. Overall, this study presents Yap as a key regulator of zebrafish Müller glia reprogramming and consequently retina regeneration upon injury.
Comprehensive Analysis of NAFLD and the Therapeutic Target Identified
Authors: Wen Weiheng , Wu Peili , Zhang Yugang , Chen Zijian , Sun Jia , Chen Hong
Published: September 2021

Objective: Non-alcoholic fatty liver disease (NAFLD) is a serious health threat worldwide. The aim of this study was to comprehensively describe the metabolic and immunologic characteristics of NAFLD, and to explore potential therapeutic drug targets for NAFLD.

Methods: Six NAFLD datasets were downloaded from the Gene Expression Omnibus (GEO) database, including GSE48452, GSE63067, GSE66676, GSE89632, GSE24807, and GSE37031. The datasets we then used to identify and analyze genes that were differentially expressed in samples from patients with NAFLD and normal subjects, followed by analysis of the metabolic and immunologic characteristics of patients with NAFLD. We also identified potential therapeutic drugs for NAFLD using the Connectivity Map (CMAP) database. Moreover, we constructed a prediction model using minimum depth random forest analysis and screened for potential therapeutic targets. Finally, therapeutic targets were verified in a fatty liver model stimulated by palmitic acid (PA).

Results: A total of 1,358 differentially expressed genes (DEGs) were obtained, which were mainly enriched in carbohydrate metabolism, lipid metabolism, and other metabolic pathways. Immune infiltration analysis showed that memory B cells, regulatory T cells and M1 macrophage were significantly up-regulated, while T cells follicular helper were down regulated in NAFLD. These may provide a reference for the immune-metabolism interaction in the pathogenesis of NAFLD. Digoxin and helveticoside were identified as potential therapeutic drugs for NAFLD via the CMAP database. In addition, a five-gene prediction model based on minimum depth random forest analysis was constructed, and the receiver operating characteristic (ROC) curves of both training and validation set reached 1. The five candidate therapeutic targets were ENO3, CXCL10, INHBE, LRRC31, and OPTN. Moreover, the efficiency of hepatocyte adipogenesis decreased after OPTN knockout, confirming the potential use of OPTN as a new therapeutic target for NAFLD.

Conclusion: This study provides a deeper insight into the molecular pathogenesis of NAFLD. We used five key genes to construct a diagnostic model with a strong predictive effect. Therefore, these five key genes may play an important role in the diagnosis and treatment of NAFLD, particularly those with increased OPTN expression.
Advances in Chromodomain Helicase DNA-Binding (CHD) Proteins Regulating Stem Cell Differentiation and Human Diseases
Authors: Liu Caojie , Kang Ning , Guo Yuchen , Gong Ping
Published: September 2021

Background: Regulation of gene expression is critical for stem cell differentiation, tissue development, and human health maintenance. Recently, epigenetic modifications of histone and chromatin remodeling have been verified as key controllers of gene expression and human diseases.

Objective: In this study, we review the role of chromodomain helicase DNA-binding (CHD) proteins in stem cell differentiation, cell fate decision, and several known human developmental disorders and cancers.

Conclusion: CHD proteins play a crucial role in stem cell differentiation and human diseases.
Characterized the Adipogenic Capacity of Adipose-Derived Stem Cell, Extracellular Matrix, and Microenvironment With Fat Components Grafting
Authors: Jiang Wenqing , Cai Junrong , Guan Jingyan , Liao Yunjun , Lu Feng , Ma Jingjing , Gao Jianhua , Zhang Yuteng
Published: September 2021

Background: Autologous fat grafting has been a widely used technique; however, the role of adipose-derived stem cells (ASCs), extracellular matrix (ECM), and microenvironment in fat regeneration are not fully understood.

Methods: Lipoaspirates were obtained and processed by inter-syringe shifting to remove adipocytes, yielding an adipocyte-free fat (Aff). Aff was then exposed to lethal dose of radiation to obtain decellularized fat (Df). To further remove microenvironment, Df was rinsed with phosphate-buffered saline (PBS) yielding rinsed decellularized fat (Rdf). Green fluorescent protein (GFP) lentivirus (LV-GFP)-transfected ASCs were added to Df to generate cell-recombinant decellularized fat (Crdf). Grafts were transplanted subcutaneously into nude mice and harvested over 3 months.

Results: Removal of adipocytes (Aff) didn’t compromise the retention of fat grafts, while additional removal of stromal vascular fraction (SVF) cells (Df) and microenvironment (Rdf) resulted in poor retention by day 90 (Aff, 82 ± 7.1% vs. Df, 28 ± 6.3%; p < 0.05; vs. Rdf, 5 ± 1.2%; p < 0.05). Addition of ASCs to Df (Crdf) partially restored its regenerative potential. Aff and Crdf exhibited rapid angiogenesis and M2-polarized macrophages infiltration, in contrast to impaired angiogenesis and M1-polarized inflammatory pattern in Df. GFP + ASCs participated in angiogenesis and displayed a phenotype of endothelial cells in Crdf.

Conclusion: Adipose ECM and microenvironment have the capacity to stimulate early adipogenesis while ECM alone cannot induce adipogenesis in vivo. By directly differentiating into endothelial cells and regulating macrophage polarization, ASCs coordinate early adipogenesis with angiogenesis and tissue remodeling, leading to better long-term retention and greater tissue integrity.
IL-13 Derived Type 2 Innate Lymphocytes Ameliorates Cardiomyocyte Apoptosis Through STAT3 Signaling Pathway
Authors: Hong Ting , Li Saiqi , Guo Xiaoyu , Wei Yazhong , Zhang Jingjing , Su Xiaohui , Zhou Miao , Jin Haizhen , Miao Qing , Shen Lei , Zhu Minfang , He Bin
Published: September 2021

The involvement of cardiomyopathy during sepsis means higher mortality and prolonged length of hospital stay. Many efforts have been made to alleviate the apoptosis of cardiomyocytes in sepsis. The huge potential of IL-13 in tissue repair has attracted increasing attention. In the present study, we used LPS-treated mice or primary cardiomyocytes as a sepsis model to explore the anti-apoptotic ability of IL-13. It was found that an increased level of exogenous IL-13 was beneficial to the recovery of heart function in sepsis, and this anti-apoptotic effect of IL-13 was probably through enhancing the phosphorylation of STAT3 Ser727. In addition, we identified that the heart protective effect of IL-13 was associated with type 2 innate lymphocytes (ILC2). All these findings may provide a potential promising treatment for sepsis-induced cardiomyopathy.
A p-n Heterojunction Based Pd/PdO@ZnO Organic Frameworks for High-Sensitivity Room-Temperature Formaldehyde Gas Sensor
Authors: Khan Faheem Ullah , Mehmood Shahid , Liu Shiliang , Xu Wei , Shah Muhammad Naeem , Zhao Xiaojin , Ma Junxian , Yang Yatao , Pan Xiaofang
Published: September 2021

As formaldehyde is an extremely toxic volatile organic pollutant, a highly sensitive and selective gas sensor for low-concentration formaldehyde monitoring is of great importance. Herein, metal-organic framework (MOF) derived Pd/PdO@ZnO porous nanostructures were synthesized through hydrothermal method followed by calcination processes. Specifically, porous Pd/PdO@ZnO nanomaterials with large surfaces were synthesized using MOFs as sacrificial templates. During the calcination procedure, an optimized temperature of 500°C was used to form a stable structure. More importantly, intensive PdO@ZnO inside the material and composite interface provides lots of p-n heterojunction to efficiently manipulate room temperature sensing performance. As the height of the energy barrier at the junction of PdO@ZnO exponentially influences the sensor resistance, the Pd/PdO@ZnO nanomaterials exhibit high sensitivity (38.57% for 100 ppm) at room temperature for 1-ppm formaldehyde with satisfactory selectivity towards (ammonia, acetone, methanol, and IPA). Besides, due to the catalytic effect of Pd and PdO, the adsorption and desorption of the gas molecules are accelerated, and the response and recovery time is as small as 256 and 264 s, respectively. Therefore, this MOF-driven strategy can prepare metal oxide composites with high surface area, well-defined morphology, and satisfactory room-temperature formaldehyde gas sensing performance for indoor air quality control.
A Recombinase Aided Amplification Assay for Rapid Detection of the Klebsiella pneumoniae Carbapenemase Gene and Its Characteristics in Klebsiella pneumoniae
Authors: Zhang Weiwei , Feng Yanling , Zhao Hanqing , Yan Chao , Feng Junxia , Gan Lin , Cui Jinghua , Liu Shiyu , Zhang Rui , Du Shuheng , Li Nannan , Xu Wenjian , Han Juqiang , Li Rongkuan , Xue Guanhua , Yuan Jing
Published: September 2021

Klebsiella pneumoniae carbapenemase genes (blaKPC) play an important role in carbapenem-resistant Enterobacteriaceae in China. A rapid detection method for blaKPC genes and investigations into the molecular characteristics of blaKPC positive Klebsiella pneumoniae were necessary. In this study, an easy and rapid recombinase aided amplification assay (RAA) for blaKPC was established. This protocol could be completed at 39°C in 15–20 min. The sensitivity of this assay was determined as 48 copies per reaction, and the specificity was 100%. The blaKPC RAA method could be used for clinical diagnosis and epidemiological investigation. Among 801 fecal samples from inpatients, 34 blaKPC positive isolates were identified from each sample, of which 23 isolates were K. pneumoniae. ST11 with blaKPC-2 was the most prevalent type. All these strains were multidrug resistant and carried various virulence genes. Fecal carriage of blaKPC positive carbapenem-resistant K.pneumoniae poses significant challenges for public health control.