bluuebunny/crossref_metadata_2025 huggingface dataset:
Effectiveness of Gamification in Knee Replacement Rehabilitation: Protocol for a Randomized Controlled Trial With a Qualitative Approach
Authors: Aartolahti Eeva , Janhunen Maarit , Katajapuu Niina , Paloneva Juha , Pamilo Konsta , Oksanen Airi , Keemu Hannes , Karvonen Mikko , Luimula Mika , Korpelainen Raija , Jämsä Timo , Mäkelä Keijo , Heinonen Ari
Published: October 2022

Background

Exergames can provide encouraging exercise options. Currently, there is limited evidence regarding home-based exergaming in the postoperative phase of total knee replacement (TKR).

Objective

This study aimed to investigate the effects of a 4-month postoperative home-based exergame intervention with an 8-month follow-up on physical function and symptoms among older persons undergoing TKR compared with home exercise using a standard protocol. In addition, a concurrent embedded design of a mixed methods study was used by including a qualitative component within a quantitative study of exergame effects.

Methods

This was a dual-center, nonblinded, two-arm, parallel group randomized controlled trial with an embedded qualitative approach. This study aimed to recruit 100 patients who underwent their first unilateral TKR (aged 60-75 years). Participants were randomized to the exergame or standard home exercise arms. Participants followed a custom-made exergame program independently at their homes daily for 4 months. The primary outcomes at 4 months were function and pain related to the knee using the Oxford Knee Score questionnaire and mobility using the Timed Up and Go test. Other outcomes, in addition to physical function, symptoms, and disability, were game user experience, exercise adherence, physical activity, and satisfaction with the operated knee. Assessments were performed at the preoperative baseline and at 2, 4, and 12 months postoperatively. Exergame adherence was followed from game computers and using a structured diary. Self-reported standard exercise was followed for 4 months of intervention and physical activity was followed for 12 months using a structured diary. Qualitative data on patients’ perspectives on rehabilitation and exergames were collected through laddering interviews at 4 and 12 months.

Results

This study was funded in 2018. Data collection began in 2019 and was completed in January 2022. The COVID-19 pandemic caused an unavoidable situation in the study for recruitment, data collection, and statistical analysis. As of November 2020, a total of 52 participants had been enrolled in the study. Primary results are expected to be published by the end of 2022.

Conclusions

Our study provides new knowledge on the effects of postoperative exergame intervention among older patients with TKR. In addition, this study provides a new understanding of gamified postoperative rehabilitation, home exercise adherence, physical function, and physical activity among older adults undergoing TKR.

Trial Registration

ClinicalTrials.gov NCT03717727; https://clinicaltrials.gov/ct2/show/NCT03717727

International Registered Report Identifier (IRRID)

RR1-10.2196/38434
Modern changes in the precipitation and air temperature regime in the mountainous regions of the Dagestan republic
Authors: Korchagina Elena
Published: October 2022

The study focuses on the local dynamics of precipitation and temperature in the mountainous regions of the Dagestan Republic (North Caucasus, eastern part). A shift in the secondary maximum of the precipitation annual distribution in the low-mountainous part of the region from August to September was found. The wettest years in the highlands in the periods 1966--1978 and 1996--2013 are discovered. The period from the beginning of the current century until now is identified as the wettest in the low-mountain zone. It was found that the trends of seasonal temperatures are positive. At the same time, the dynamics of spring temperatures remained insignificant in the low-mountain zone until 2010. It was revealed that the statistically reliable increase of temperature in February and March and unidirectional tendencies in the daily characteristics of precipitation is the local pattern of the climate change in this part of the North Caucasus. In this season the increase in the average and maximum daily precipitation intensity is reliable.
AUTORITARIZAM U CRNOJ GORI OD 1990. DO 2020. GODINE
Authors: Todorovic Vladica
Published: October 2022

U radu smo se bavili autoritarizmom u Crnoj Gori u periodu od 1990. do 2020. godine. Istraživanje smo počeli od uspostavljanja višestranačkog sistema u Crnoj Gori 1990. godine, kada vlast osvaja, odnosno zadržava, Savez komunista Crne Gore, koji ubrzo menja ime u Demokratska partija socijalista Crne Gore, koja vlada narednih 30 godina, sve do 2020. kada na parlamentarnim izborima 30. avgusta gubi vlast. DPS je u različitim periodima menjao politiku prema zajedničkoj državi sa Srbijom, srpskom identitetu, srpskom jeziku, Srpskoj pravoslavnoj crkvi, ali i pored promene politike, 30 godina nije izgubio vlast na parlamentarnom nivou, dok je njihov predsednički kandidat uvek pobeđivao na predsedničkim izborima, a i danas predsednik Crne Gore je iz DPS-a. Analizirali smo u kojim okolnostima su se javljali ali i intenzivirali periodi autoritarizma, što je u najvećem periodu karakterisalo vlast ove stranke. Pretpostavljamo da se autoritarizam javljao zbog procesa uspostavljanja nezavisne države Crne Gore i da je kasnije intenziviran zbog konsolidacije države Crne Gore i crnogorske nacije. U radu smo koristili komparativnu metodu i metodu analize sadržaja.
PISMO FELDMARŠALA MINIHA KNEZU LOBKOVICU POVODOM BEOGRADSKOG MIRA 1739. GODINE
Authors: Radusinovic Milorad
Published: October 2022

Pismo ruskog feldmaršala Miniha austrijskom knezu Lobkovicu (Lobkoviču) je dokument koji ilustruje nezadovoljstvo Rusije slabašnim otporom Austrije Turskoj , kad je Habsburška monarhija nakon poraza kod Grocke 22. jula 1739. ustupila Turskom carstvu sjevernu Srbiju sa Beogradom.
Dokument (koji objavljujemo u prevodu na srpski jezik) danas se čuva u CGADA (Centralьnый gosudarstvennый arhiv drevnih aktov,tureckie dela) u Moskvi.
RADOMIR LUKIĆ: POLITIKOLOŠKA I FILOSOFSKA MISAO
Authors: Nadoveza Branko
Published: October 2022

Radomir Lukić je u mnogim svojim radovima dao veliki doprinos politikološkoj nauci i filozofiji prava. Gotovo da nema društvene pojave koju on nije sagledao ne samo sa pravne pozicije, već i sa pozicije politikologije i filozofije prava. Smatrajući da između tih struktura često i nema granice.
ULOGA NACIONALNIH KONFERENCIJA U DEMOKRATIZACIJI U FRANKOFONOJ AFRICI
Authors: Sidi Dijavara Seku
Published: October 2022

Proces demokratizacije je u velikoj meri privukao pažnju autora i istraživača političkih nauka u cilju rasvetljavanja njenih uzroka, posledica, izgleda, a posebno faktora koji su uslovili njegovo uvođenje širom sveta. Metode i politike njegovog usvajanja bile su različite od države do države, regina do regiona i kontinenta. Razlikujući se od drugih regiona sveta, frankofone afričke države su krenule posebnim putem da započnu proces demokratizacije: organizovanjem nacionalnih konferencija. Stoga se u ovom članku analizira doprinos nacionalnih konferencija organizovanih u svim frankofonim afričkim državama u cilju započinjanja procesa demokratizacije. Da bi to uradio, autor prvo opisuje društveno-političko-istorijski tok procesa demokratizacije i različite modalitete iz kojih se dalje širila. Zatim, koristeći institucionalni pristup da bi ispitivao ustavne i institucionalne orijentacije frankofonih afričkih zemalja, on ne samo da utvrđuje izazove sa kojima se demokratija suočava u ovim zemljama, već i pokušava da iznese hipoteze koje se mogu smatrati varijablama za objašnjenje pada demokratije u tim zemljama, što predstavlja jedan od glavnih ciljeva ovog rada. Na kraju, nakon kratke ocene nacionalnih konferencija, autor se oslanja na konkretne činjenice kako bi dao predloge koji bi mogli da doprinesu konsolidaciji demokratije u navedenim državama.
Plantas americanas utilizadas como condimento en la cocina mexicana
Authors: Lascurain-Rangel Maite , Avendaño-Reyes Sergio , Tan Richard , Caballero Javier , Cortés-Zárraga Laura , Linares-Mazari Edelmira , López-Binnqüist Citlalli , De Ávila Alejandro
Published: October 2022

La cocina de México forma parte de su identidad alimentaria, es reconocida por la gran diversidad biocultural y por la convergencia de raíces indígenas y extranjeras. El objetivo de esta contribución fue catalogar especies condimentarias de origen americano utilizadas en la cocina mexicana y proponer una clasificación de sus formas de uso y consumo. Se realizó una recopilación de datos a partir de bibliografía y consulta a la “Base de Datos Etnobotánicos de Plantas Útiles de México” del Jardín Botánico del Instituto de Biología, UNAM. Se catalogaron 256 especies, 218 son silvestres y de ellas, 50 son endémicas de México, 5 están reguladas en la NOM-059-SEMARNAT-2010. La estructura vegetal más mencionada fue la hoja (145) y la forma biológica fueron las hierbas (118). Los condimentos se clasificaron en 3 grupos: a) aditivos (193 especies) divididos en colorantes, sales, edulcorantes y otros diversos, y complejos (plantas que comparten nombre, olor y sabor similar), incluyen 8 formas de preparación de alimentos; b) materiales (66) divididos en envoltura de alimentos, envoltura de tamales, cubrimiento de hornos y leña; y c) condimentos comidos crudos (42) que acompañan y/o complementan alimentos.
Resident jaguars (Panthera onca) at the heart of the Maya Forest in Guatemala
Authors: Gaitán Carlos A. , González-Castillo Vivian Roxana , Guzmán-Flores Gerber Daniel , González-Xiloj Pablo Andrés , Bá Usi'j Tz'nunja' , García-Anleu Rony A. , García Manolo José
Published: October 2022

In this study we determined the resident status of individual jaguars (Panthera onca) in a 7-year timeframe, in order to provide insight into the life history of this species as an input for abundance estimations and the management of the Maya Forest shared by Guatemala, Mexico, and Belize. We gathered photographic jaguar records from studies conducted in 2 Core Zones of the Maya Biosphere Reserve from 2013 to 2019. Individual jaguars were identified by their unique coat pattern, and were considered as residents when recorded for 3 or more consecutive years. Also, range sharing and interactions were quantified. Both female and male resident individuals were recorded. We suggest the presence of a resident population with a tendency for spatial or temporal range exclusion within individuals from the same sex and a fast male’s turnover, and a demographically mixed group of transients. These circumstances appoint the relevance to determine the resident status of individuals for accurate abundance estimations and population trends, and also in maintaining the integrity of the transboundary continuous forest cover, as connectivity appears to have an important role for maintaining the fluctuating jaguar population dynamics.
Políticas de información en las bibliotecas del Congreso General de los Estados Unidos Mexicanos
Authors: Vargas Huerta Arturo
Published: October 2022

El artículo presenta las políticas de información de las bibliotecas del H. Congreso de la Unión de México. Realiza un diagnóstico sobre sus áreas, servicios, colecciones y personal por medio de entrevistas a los responsables de las bibliotecas en su lugar de trabajo. Interroga si en cada una de las áreas, servicios, manejo de las colecciones y selección del personal se tiene una política de información que les indique como se llevan a cabo las actividades. El instrumento es un cuestionario que se elaboró con base en las Directrices para bibliotecas parlamentarias creadas por la IFLA. Es una investigación documental y de campo. La muestra que se estudió son las tres bibliotecas que pertenecen al sistema. Compara lo que dice la IFLA sobre las directrices que deben tener este tipo de bibliotecas, con las políticas que se encontraron en la investigación documental y de campo. Los resultados obtenidos demuestran que sí cuentan con políticas de información explícitas en los niveles macro, mezzo y micro. Concluye que es necesario que los responsables de las bibliotecas elaboren, implementen, evalúen y mejoren políticas de información que les ayuden a alcanzar sus objetivos y metas.
FDA Regulatory Implications for Co-crystals and recent Co-crystal Patents
Authors: Samuel Rigilin  , Kunjal Krishnananda Kamath , Thayyil Abdul Raheem , Shabaraya Ramakrishna
Published: October 2022

One of the most crucial stages in the creation of a medicinal product is the characterization of an Active Pharmaceutical Ingredient (API). Unfortunately, not all APIs have the ideal characteristics for medicinal usage. Many freshly discovered active compounds, for example, have low solubility. However, various methods have been developed to change and improve an API's features to get desired physicochemical properties, which is an important tool in formulation development. The production of salt derivatives is a common technique for increasing the solubility of an active chemical. This method, however, has limits because not every API has the qualities to be transformed into a salt. In recent years, a novel engineering approach for creating new API forms with desirable features has been established. The development of pharmaceutical co-crystals is the result of these efforts which allow pharmaceutical companies to customise existing APIs or create new ones with specific properties. Aside from the scientific hurdles that come with developing a pharmaceutical, manufacturers are also faced with regulatory regulations that must be met in order to get approval and access the market. As pharmaceutical co-crystals are a relatively new API, little regulatory guidance for co-crystals has been developed for one of the world's largest pharmaceutical market the United States of America (USA).

This article will look at what regulatory standards must be met in order to employ pharmaceutical co-crystals in generic medications intended for use in the United States. It will also go over which data should be included in the common technical document to justify its existence. In addition to, a brief information of various patents on co-crystals have also been included for better knowledge of the reader.
Stability-Indicating Analytical Method Development and Validation of Thiocolchicoside and Ibuprofen in Tablet Dosage Form by RP-HPLC Method
Authors: Jadhav Ankush P. , Datar Prasanna A. , Kedar Tejashree R. , Kardile Deepak P.
Published: October 2022

Objective: First time, a simple, specific, accurate and economic stability-indicating reverse phase high performance liquid chromatographic method was reported for the simultaneous estimation of THIO and IBU in tablet dosage form. Method: The method has shown adequate separation of THIO and IBU from their degradation products. Separation was achieved on an Inertsil, 3V ODS C18, 4.6 mm x 250 mm, 5μ column at wavelength of 248 nm, using a mobile phase Methanol: Dist. water (50:50, v/v) in a mode of isocratic elution at a flow rate of 1.0 ml/min. Results: This method results has minimum retention time for THIO and IBU i.e. 2.317 and 1.075 min. correspondingly, which gives fast separations of drugs furthermore both drug combinations are subjected to acidic, base, oxidation, thermal and photolytic stress environment. Thus stressed samples of these drugs are analyzed by the proposed analytical method. Quantitation was achieve with UV detection at 248 nm based on peak area with linear calibration curve at concentration range 100-600 ppm for THIO and 400-2400 ppm for IBU. The LOD's found 2.00 and 0.54 for THIO and IBU in addition to that LOQ's were found to be 6.08 and 1.63 resp. Conclusion: The statistical analysis proved that this novel proposed method was established to be specific, accurate, precise and stability-indicating study do not shows interfering peaks of degrades and excipient. The proposed method is therefore suitable for purpose in quality-control laboratories for quantitative analysis of THIO and IBU drugs individually and in combined dosage form, as it is performed and validated as per ICH Q2 (R1) and Q1A (R2) guideline and it meets to specific acceptance criteria.

Keywords: Thiocolchicoside (THIO), Ibuprofen (IBU), RP-HPLC, Stability-indicating, ICH.
ADMET informatics of Plant Derived n-Hexadecanoic Acid (Palmitic Acid) from ethyl acetate fraction of Moringa oleifera leaf extract
Authors: Krishnaveni K. , Murugan M. , Kalaimathi RV. , Basha AN. , Pallan GA. , Kandeepan C. , Senthilkumar N. , Mathialagan B. , Ramya S. , Jayakumararaj R. , Loganathan T. , Pandiarajan G. , Kaliraj P. , Dhakar Ram Chand
Published: October 2022

Palmitic Acid (PA) is known to exert multiple fundamental biological functions at cellular and tissue levels and its steady concentration is guaranteed by its endogenous synthesis by DNL. PA has been for a long time negatively represented for its detrimental health effects tailing its essential physiological attributes. PA has been portrayed to serve as a signalling molecule regulating the progression and development of many diseases at molecular level. Controversial data on the association of dietary PA with detrimental health effects has been related to several parameters such as fatty acid/ macronutrient imbalance by altered lipid metabolism, positive energy balance, excessive intake of carbohydrates, imbalance of dietary PA/PUFA, physiopathological conditions, presence of enhanced DNL and sedentary lifestyle. This may result in dyslipidemia, hyperglycemia, increased ectopic fat accumulation and increased inflammatory tone indicating that clear understanding of system based PA metabolism is still lacking. In the present study an attempt has been made to bring out the absorption, distribution, metabolism, elimination and toxicity profile of PA. Results are expected to have some implications in elucidating the molecular mechanisms that regulates pathophysiological events involved in hyperglycemia/ hyperlipidemia-induced complications associated with diabesity and CVD. Besides it may provide a better understanding to identify key molecular targets for therapeutic management of PA induced metabolic disorders.

Keywords: Moringa oleifera; MOLE; Bioactive Secondary Metabolites; ADME/Tox; Natural Products (NPs); PBNPs; PDHA; n-Hexadecanoic Acid (nHDA); Palmitic Acid (PA)
Combination of Foot Massage and Compression Stocking (EDEFOCS) for Women with Edema in Pregnancy is Feasible Option
Authors: Hevrialni Rully
Published: October 2022

Edema in pregnancy often occurs. Nearly 80% of all pregnancies can occur in leg edema which is a small problem that can provide initial symptoms for various diseases and pathological conditions and can be an indicator of serious chronic disease. Various methods of management to prevent and treat edema in pregnancy are by compression stocking and foot massage. The purpose of this study was to analyze the effect of foot massage and compression stocking on pain intensity and the degree of edema in pregnant women Trimester III. The type of research is quasi experiment and using a pretest-posttest control group design with 3 treatment groups, namely foot massage, compression stocking and a combination of foot massage and compression stocking. The population of this study was all Trimester III pregnant women with edema in Pekanbaru City. The sampling technique used purposive sampling with inclusion criteria. This research was conducted on April 9 to September 15, 2018 in Pekanbaru City Health Center namely Rumbai Health Center, Umbansari Health Center and Melur Health Center. Data analysis using Annova Test. The results showed that in the combination group of foot massage and compression stocking the decrease in the average pain intensity was 1.8 and the decrease in the average degree of edema was 1.6 mm. There is the effect of foot massage, compression stocking and a combination of foot massage and compression stocking on pain intensity and degree of edema (p -value = 0.00. The group that most significantly reduces pain intensity and the degree of edema is a combination of foot massage and compression stocking. Recommended for health workers in order to use the method of foot massage, compression stocking and a combination of foot massage and compression stocking in preventing and reducing edema in pregnant women.

Keywords: Foot massage, compression stocking, Pain intensity, Degree of edema, Third trimester of pregnancy
Heisenberg-limited quantum phase estimation of multiple eigenvalues with few control qubits
Authors: Dutkiewicz Alicja , Terhal Barbara M. , O'Brien Thomas E.
Published: October 2022

Quantum phase estimation is a cornerstone in quantum algorithm design, allowing for the inference of eigenvalues of exponentially-large sparse matrices.The maximum rate at which these eigenvalues may be learned, –known as the Heisenberg limit–, is constrained by bounds on the circuit complexity required to simulate an arbitrary Hamiltonian. Single-control qubit variants of quantum phase estimation that do not require coherence between experiments have garnered interest in recent years due to lower circuit depth and minimal qubit overhead. In this work we show that these methods can achieve the Heisenberg limit, also when one is unable to prepare eigenstates of the system. Given a quantum subroutine which provides samples of a `phase function' g(k)=∑jAjeiϕjk with unknown eigenphases ϕj and overlaps Aj at quantum cost O(k), we show how to estimate the phases {ϕj} with (root-mean-square) error δ for total quantum cost T=O(δ−1). Our scheme combines the idea of Heisenberg-limited multi-order quantum phase estimation for a single eigenvalue phase [Higgins et al (2009) and Kimmel et al (2015)] with subroutines with so-called dense quantum phase estimation which uses classical processing via time-series analysis for the QEEP problem [Somma (2019)] or the matrix pencil method. For our algorithm which adaptively fixes the choice for k in g(k) we prove Heisenberg-limited scaling when we use the time-series/QEEP subroutine. We present numerical evidence that using the matrix pencil technique the algorithm can achieve Heisenberg-limited scaling as well.
Fuga de información por ultrasonido: un delito sobre datos personales
Authors: Vargas Montoya Héctor Fernando , Vallejo Pinilla Clay Schneider , Ruiz Patiño Carlos Augusto
Published: October 2022

La utilización de mecanismos como la transmisión de datos por ondas ultrasónicas puede permitir que malintencionados logren obtener datos personales de un sistema de cómputo, lo que podría constituir un delito informático. El objetivo de este artículo es demostrar cómo es posible filtrar información a través del ultrasonido, haciendo uso de los sistemas periféricos de estaciones de trabajo, con lo cual, se podrían obtener datos personales generando un problema de confidencialidad y un posible delito. Para ello, el método utilizado, fue realizar una caracterización de componentes informáticos, construir un software de apoyo para el envío y recepción de datos por ultrasonido (en una frecuencia por encima de los 18000 Hz) haciendo uso de los altavoces de un equipo computacional y la recepción datos fue desde otro equipo portátil, las pruebas fueron realizadas en un ambiente controlado con bajo ruido. Como resultado se pudo transferir información a través de elementos computacionales básicos, aunque con alguna pérdida de paquetes, pero funcional para el cumplimiento del objetivo propuesto, con lo cual, se concluye que es posible a través de ultrasonido filtrar datos y que alguna de esta información puede generar un delito informático a la luz de la Ley 1273 de 2009 en Colombia.
Social responsibility disclosure: Do green accounting, CEO power, board gender, and nationality diversity matter?
Authors: Andrian Tommy , Pangestu Andrian
Published: October 2022

Indonesia’s Environmental, Social and Governance Index (ESG Index) score and ranking released by the Global Risk Profile (2020) indicate that the social responsibility disclosure of companies in Indonesia is still very minimum. This study aims to analyze the effects of green accounting, Chief Executive Officer (CEO) power, gender diversity, and nationality diversity on social responsibility disclosure. This study uses ISO 26000 to assess social responsibility disclosure to measure and report social responsibility policies and practices to provide new perspectives for business people. This study uses a quantitative approach and panel data regression on 102 financial sector companies listed on the Indonesia Stock Exchange (IDX) for the 2018–2020 period. The analysis technique uses multiple linear regression analysis with statistical tools SPSS 20. The results show that green accounting, CEO power, and gender diversity of the board of commissioners do not affect social responsibility disclosure. In contrast, the national diversity of the board of commissioners has a significant negative effect on social responsibility disclosure. Human rights and fair operating practices are subjects that companies need to highlight to increase social responsibility disclosure while increasing transparency of the allocation of costs that companies spend on social and environmental sectors.
Conversation-as-Material
Authors: Emma Cocker
Published: October 2022

Published as part of: Emma Cocker, 'Conversation-as-Material', in the Special Issue 'Practices of Phenomenological and Artistic Research', (eds.) Alex Arteaga, Emma Cocker, Erika Goble, Juha Himanka, Phenomenology & Practice, [Vol. 17, No.1, 2022], pp.193-223. ISSN 1913-4711. See full issue here: https://journals.library.ualberta.ca/pandpr/index.php/pandpr/index
The efficacy and safety of prophylactic antibiotics for post-acute stroke infection: a systematic review and meta-analysis
Authors: Wang Qing , Wu Ziyang , Tang Huilin , Yi Zhan-Miao , Zhai Suo-Di
Published: October 2022

Background: Infections are common complications after stroke and
associated with unfavorable outcomes. We evaluated the efficacy and
safety of prophylactic antibiotics for post-acute stroke infection.
Methods: We searched PubMed, Embase, the Cochrane Library, SinoMed,
China National Knowledge Infrastructure, and WanFangData from inception
to February 15th, 2022. We calculated the pooled risk ratio (RR) and
mean differences (MDs) with 95% confidence interval (CI), evaluated the
risk of bias and conducted sensitivity analysis with RevMan version
5.4.1 and Stata version 14.0 software. The overall quality of evidence
was evaluated using the Grading of Recommendations, Assessment,
Development and Evaluations (GRADE) approach. Results: Twelve studies
(4809 participants) were included in this meta-analysis. There was no
significant difference in the mortality rate [RR 1.03 (95% Cl:
0.91-1.16)], pneumonia [RR 0.94 (95% CI: 0.79-1.11)], and the
incidence of adverse events between the prophylactic antibiotics and
control groups. Prophylactic antibiotics significantly reduced the
incidence of infections [RR 0.72 (95% Cl: 0.58-0.89)], and urinary
tract infections [RR 0.39 (95% Cl: 0.3-0.49)] in patients with
acute stroke. We performed a subgroup analysis and found a decreasing
trend in pneumonia in patients with early prophylactic use of
antibiotics within 24 hours after admission [RR 0.81 (95%CI:
0.62-1.07)] as compared with those using prophylactic use of
antibiotics within 48 hours after admission [RR 0.94 (95%CI:
0.79-1.11)]. Conclusions: Prophylactic antibiotics did not
significantly reduce the mortality rate and pneumonia in patients with
acute stroke but reduced the incidence of infections and urinary tract
infections.
Auxotrophs compromise bio-production in yeast Saccharomyces cerevisiae
Authors: Yan Chunxiao , Gao Ning , Cao Xuan , Yao Lun , Zhou Yongjin , Gao Jiaoqi
Published: October 2022

Auxotrophic marker genes have widely used for genetic engineering in
yeast. However, the effects of auxotrophic strains that are deficient in
synthesis of amino acids or nucleotides on the growth and production are
rarely reported. In this study, a total of eight auxotrophic strains
with single knockout of selective markers were obtained to evaluate cell
growth and free fatty acid (FFA) production in Saccharomyces cerevisiae
with supplementing different concentrations of amino acids or
nucleotides. Generally, except for gene ADE2, most auxotrophic strains
possessed decreased cell growth and FFA production, which could be
remedied by the higher concentrations of supplements. leu2Δ damaged both
growth and production even with supplementation of 1000 mg/L leucine.
Therefore, this study shows that auxotrophs compromise the metabolic
engineering endeavor and provides a guidance in supplementing amino
acids or nucleotides during fermentations for maximizing
bio-productions.
No más respiro al Leviatán: criminalidad estatal regularizada. Narrativas generacionales que desmantelan el orden democrático racista-sexista-elitista desde Colombia
Authors: Botero-Gómez Patricia
Published: October 2022

En este texto resalto las relaciones que se encubren en el engranaje del sistema político-estatal genocida y la reiterada negación de las posibilidades de futuro en el rostro de las generaciones más jóvenes, desde la perspectiva estadocéntrica. En esta escribanía retomo algunas reflexiones que venimos realizando con diferentes colectivos intergeneracionales. Focalizaré una pequeña (n)etnografía frente a los comunicados internos y noticias que circularon en la movilización masiva de jóvenes en Colombia, especialmente, frente a los abusos de poder y criminalización de la protesta y la persecución de jóvenes pertenecientes a barrios populares y pueblos ancestrales; retomaré algunas narrativas y prácticas teóricas emergentes desde las voces intergeneracionales y de tejidos de vida que van desmantelando y desestructurando los sistemas de muerte y que están manteniendo la vida y la esperanza, leídos en una hermenéutica colectiva desde los bioterritorios Kumanday y del suroccidente colombianos.
Hepatocellular Carcinoma: Systematic Review of Relevant Biomarkers and the Impact on Liver Resections
Authors: Bocșe Horea , Ciocan Andra , Zaharie Florin V. , Ciocan Răzvan A. , Al Hajjar Nadim
Published: October 2022

Background: Hepatocellular carcinoma (HCC) is the primary cancer of the liver representing the 6th cause of cancer worldwide and the 3rd in terms of deaths per year. Recent advances have offered new treatment options for this disease. New links between biomarkers and patients’ prognosis show a great potential for a more precise and targeted therapy. Method: A systematic review was performed following the guidelines outlined by The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Original articles published in the online database, Pubmed (Medline), Embase and Cochrane from January 2017 to February 2022 were screened after using specific keywords. Results: A total of 1300 studies was obtained by searching through online databases. Following the exclusion criteria, we included 18 studies in the systematic review. Conclusions: Biological markers are playing an important role for the prognosis of HCC. Alfa-fetoprotein (AFP) is still a valid biomarker, that can help stratify the risk for patients with HCC. Meanwhile, the current advancements in the field of miRNAs open new opportunities to analyse the role of miRNAs in HCC. Studies conducted on targeted therapies should also take into consideration the levels of these biomarkers, statistically linked with the prognosis of patients after liver resections.
The Pagoda of the Gods: A case for Indigenous Karen sacred sites as Special Cultural Zones along Thailand’s borders
Authors: Phatthanaphraiwan Suwichan , Zeitler Lilly , Fairfield Benjamin
Published: October 2022

Burgeoning recognition of Indigenous traditional ecological knowledge and livelihood practices have led to ‘Special Cultural Zone’ designations for some traditionally Indigenous lands in Thailand. Simultaneously, the Thai government has designated 10 Special Economic Zones (SEZs) to bolster trade and investments along its borders without acknowledging the pre-existence of Indigenous peoples. SEZs intersect with sites of notable cultural significance, such as Kho Pho Lu (Pagoda of the Gods), a sacred site for Indigenous Karen near Mae Sot in Tak province. Detailed ethnographic and interview findings show the resilience of these sacred sites and embedded ritualistic place-making practices that persist despite a legacy of Indigenous displacement. Ethnobotanical findings of 39 sampled taxa in the sacred forest of Kho Pho Lu indicate that cultural and spiritual practices support local biodiversity conservation. Potential biocultural conservation approaches include the adoption of ‘Special Cultural Zones’ to promote Indigenous well-being and the preservation of biocultural diversity in Thailand.
CIE S 014-1:2006 Colorimetry - Part 1: CIE Standard Colorimetric Observers
Authors:   CIE
Published: October 2022

Superseded by Colorimetry - Part 1: CIE Standard Colorimetric Observers, 2nd Edition-\n--\n-Joint ISO/CIE Standard-\n--\n-ISO 11664-1:2007(E)/CIE S 014-1/E:2006-\n--\n-This CIE Standard replaces ISO/CIE 10527:1991. This Standard contains only minor changes from the previous Standard, it has now been clarified that the values of the colour matching functions apply for standard air to make the Standard conform to other CIE photometric and colorimetric data.-\n--\n-Colours with different spectral compositions can look alike. An important function of colorimetry is to determine whether a pair of such metameric colours will look alike. It has long been the practice in colorimetry to make use of sets of colour-matching functions to calculate tristimulus values for colours: equality of tristimulus values for a pair of colours indicates that the colour appearances of the two colours match, when they are viewed in the same conditions by an observer for whom the colour-matching functions apply. The use of standard sets of colour-matching functions makes the comparison of tristimulus values obtained at different times and locations possible.-\n--\n-This International Standard specifies colour-matching functions for use in colorimetry. Two sets of colour-matching functions are specified:-\n--\n-Colour-matching functions for the CIE 1931 standard colorimetric observer-\n--\n-This set of colour-matching functions is representative of the colour-matching properties of observers with normal colour vision for visual field sizes of angular subtense from about 1� to about 4�, for vision at photopic levels of adaptation.-\n--\n-Colour-matching functions for the CIE 1964 supplementary standard colorimetric observer-\n--\n-This set of colour-matching functions is representative of the colour-matching properties of observers with normal colour vision for visual field sizes of angular subtense greater than about 4�, for vision at sufficiently high photopic levels and with spectral power distributions such that no participation of the rod receptors of the retina is to be expected.-\n--\n-The values in the tables of the colour matching functions and chromaticity coordinates of the CIE 1931 and 1964 standard colorimetric observers are identical with those in the previous standard.
CIE 093-1992 Road lighting as an accident countermeasure
Authors:   CIE TC 4-02
Published: October 2022

Road accidents at night are disproportionately high in numbers and severity compared to day. The major factor contributing to this problem is darkness because of its great influence on the driver's behaviour and ability. At night man's visual capabilities are impaired and visibility is reduced. Thus road lighting is a potential countermeasure.-\n--\n-Sixty-two lighting and accident studies, from 15 countries, have been rigourously analysed. Some 85% of results show lighting to be beneficial, with about one third of these having statistical significance. These lead to the general conclusion that road lighting on traffic routes will reduce the incidence of night accidents. Depending on the class of road and the accident classification involved, the statistically significant results show reductions of between 13% and 75%.-\n--\n-Depending on the road and traffic classification, cost benefit studies show the accident savings to more than offset the cost of lighting. In the report, warrants for lighting related to accidents and traffic volume are developed. The findings can assist in the preparation of national standards and in decisions onthe implementation of road lighting programmes. Keywords: accidents, motorized traffic, road lighting
CIE 109-1994 A method of predicting corresponding colours under different chromatic and illuminance adaptations
Authors:   CIE TC 1-32
Published: October 2022

The technical report CIE 109-1994 describes a method for predicting various effects of chromatic adaptation over a wide range of adapting illuminant and illuminance conditions. These effects are estimated using corresponding colours.-\n--\n-The computational procedure and applicable conditions are also included. The method should only be used for object colour samples. This method was previously proposed for study by the CIE in 1986 and is presented here with the purpose of incorporating recent extensions. In addition, the procedures are given for excluding systematic errors found in the experimental determinations of corresponding colours.-\n--\n-The corresponding colours are defined as a pair of samples that would elicit the same colour appearance when one sample is viewed under one illumination condition, and the other under a different illumination condition; corresponding colours are always expressed in terms of two sets of tristimulus values. This is an asymmetric colour matching situation, where asymmetry is caused by different illumination conditions. The mathematical model for predicting the corresponding colours is known as a chromatic adaptation transform.-\n--\n-The present method is not a CIE recommendation. It is always to be expected that the method reported by the CIE will be tested by future observation, experimentation, and theoretical study. The chromatic adaptation transform presented in this report will also be tested by future studies, including those since 1986.-\n--\n-This technical report contains 18 pages, with 3 figures and 2 tables. At the time of publishing above technical report, CIE-CB publishes two computer programs for personal computers running under DOS or MS-WINDOWS* on its disk D007 Rel. 1.0-1994. Both versions of the program enable the calculation of the corresponding colour. The test and reference illuminant chromaticities and illuminances as well as the luminance factor of the background can be user-defined.-\n--\n-D007 is available as 3,5 or a CD-ROM, to be used under DOS/WINDOWS operating system. Keywords: adaptation, chromatic adaptation, colorimetry, colour, colour appearance, colour perception
CIE 205:2013 Review of Lighting Quality Measures for Interior Lighting with LED Lighting Systems
Authors:   CIE TC 3-50
Published: October 2022

With recent increases in luminous flux and efficacy, LEDs have started to compete with conventional light sources in luminaires for general lighting. Typical LED characteristics, such as directional light, small size and high brightness are as such not new light source characteristics; nonetheless they are (alone or as combination) new characteristics in some areas of functional interior lighting, such as offices, class rooms, meeting rooms or patient rooms. Most existing quality measures for those applications are derived from research with and referring to the use of diffuse fluorescent lighting. This report provides information on the suitability of existing lighting quality measures when applied to (commercial) interior LED lighting systems. It identifies the gaps and weaknesses in existing quality measures, recommends new quality measures and includes suggestions for required research. Keywords: lighting design, interior lighting, LED
Integration of Function Analysis and Trimming Method: A Systematic Approach for Improving a Spinal Board Design
Authors: Zadry Hilma , Susanti Lusi , Uswansyaf Gamma
Published: October 2022

Function analysis primarily distinguishes components in a system and explains the function interactions amongst the components' pairs. It assists designers in revealing the main problematic areas (components) and contradictions. The trimming method assists in generating a simple design; thus, it can reduce costs and the number of faults. This study integrated the function analysis and trimming method as a systematic approach to product concept design based on the problem-oriented concept. A spinal board is an evacuation device for patients with an injured spinal cord. A case study of improving a spinal board design is conducted to demonstrate the applicability of the proposed approach. The study resulted in an alternate design of spinal board with some inventions which deliver improved performance in decreasing injury, increasing comfort and safety, and satisfying the users' requirements.
Rancang Bangun Aplikasi Media Pembelajaran Interaktif Pengenalan Komputer Dan Kuis Pilihan Ganda Berbasis Web
Authors: Permatasari Intan , Nugraha Nunu
Published: October 2022

Penelitian ini bertujuan untuk merancang dan membangun apalikasi media pembelajaran berbasis flash pada mata pelajaran TIK dengan topik pengenalan komputer. Aplikasi ini dibuat sebagai media pembelajaran bagi siswa kelas XI MTs Al Ma’Mur Ciawigajah. Aplikasi media pembelajaran berbasis flash dapat digunakan sebagai salah satu alternatif media pembelajaran bagi siswa. Metode yang digunakan dalam merancang dan membangun aplikasi menggunakaan metode waterfall, terdiri dari lima tahap yaitu Requirement Analisis, System Design, Implementation, Integration Testing dan Operation Maintenance. Berdasarkan hasil implementasi dan pengujian aplikasi, bahwa aplikasi dapat berjalan dengan baik sesuai dengan spesifikasi yang dibutuhkan, dan dapat digunakan sebagai media pembelajaran siswa. Fitur kuis yang terdapat pada aplikasi pembelajaran dapat digunakan sebagai bahan evaluasi bagi guru dalam memberikan penilaian hasil belajar siswa. Kata kunci : Media, Pembelajaran, Flash, Komputer, Aplikasi
Rancang Bangun Game Edukasi Pengenalan Hewan Berbasis Android Menggunakan Unity 3D
Authors: Fauziah Fauziah , Arrifqie Andy Kurnia
Published: October 2022

Today technology increases rapidl. It should be used in every side of human lifewhich aims to get information. It is useful, helpful and it facilitates human life. The role oftechnology is not only seen in an adult's life, but also children’s lifes, especially in education. The technology will be focused in this research is the technology insmart phones and android, in order to facilitate the child in learning animals introduction. In thedevelopment of this application, it is made as easy as possible in operational control on the gameplay. Education game assessed can add interest in learning according to the survey conducted with the results of the questionnaire from respondents. This game can be run on an android device onsome versions of the operating system, such as Jellybean, Kitkat and Lollipop.Education game is as a means of learning at the same time playing for children, especially children aged 4-6years in order to learn more about the names of the animals.Keywords: game, android, unity 3D, education.
Investigator's Intuition: Conditions of Formation and the Possibility of Implementation of Artificial Intelligence
Authors: Tsvetkova Anna Denisovna
Published: October 2022

The paper examines the issues of intuition in investigative practice. Relying on the positions of prominent forensic scientists, the importance of this heuristic mechanism for overcoming deadlocks caused not only by a shortage of information, but also by its overabundance is substantiated. The author suggests mechanisms for the development of intuition, the main of which is called the expansion of erudition, the accumulation of a large number of background knowledge. The second part of the article discusses the problems of artificial intelligence. Firstly, the topic of its potential to replace a person is covered. Secondly, the position existing in science is refuted, according to which the work of artificial neural networks is characterized as intuitive.   Based on the analysis of practical examples and the synthesis of various scientific positions, the author formulated the following conclusions: 1. The intuitive decisions based on the probabilistic assumption assist the investigator in choosing specific investigative actions or tactics for their conduct. 2. Intuition is best developed among investigators with average work experience and broad erudition. 3. Intuition can and should be developed, mainly by expanding erudition, accumulating background experience. 4. The work of artificial neural networks cannot be called completely intuitive, since they act according to a given algorithm, even if generating a solution that is not accessible to human perception, whereas intuition is a creative process that goes beyond standard models. 5. To date, there is only a weak artificial intelligence, which is able to cover only situations of an overabundance of information, but not its deficit, although the latter very often require an appeal to intuition. 6. Intuition is a competitive advantage of humans over artificial intelligence, allowing our species to think more broadly, more versatile.
K. G. Paustovsky's Story "The Rook in the trolleybus" as an early Text of the Thaw
Authors: Elizarova Nataliya Mikhailovna , Nikolskaya Tatiana
Published: October 2022

K. G. Paustovsky's story "The Rook in the trolleybus" traditionally refers to works of children's literature. The interpretation presented in the article allows us to take out this story from the school niche and consider it in the light of the socio-political changes that began in Soviet society after Stalin's death. The subject of the research is the linguistic composition of the story and the non–textual information - background knowledge relevant for understanding the author's idea. The work of art is considered in line with the integral approach: methods and techniques of linguo-stylistic, literary and discursive analysis are applied. This approach is based on the understanding of the work of literature as a dialectical unity of form and content and at the same time as one of the components of artistic communication. The scientific novelty of the work is determined by the fact that the story "The Rook in the trolleybus" has never been subjected to an integral analysis before and, therefore, the conclusions drawn as a result of the application of this approach are original. Generalization of all observations and analysis of the text as a formal and meaningful whole lead to the general conclusion that "The Rook in the trolleybus" is an early text of the post-Stalin thaw. Russian language, literature and, possibly, history lessons, as well as university courses of stylistic analysis and interpretation of the text, the history of Russian and Soviet literature, in special courses devoted to the study of the creative biography of K. G. Paustovsky, can be widely used in the study of the results of the study and its techniques.