bluuebunny/crossref_metadata_2025 huggingface dataset:
A Comparison Between Catalyst‐Free and ZrOCl2⋅8H2O‐Catalyzed Strecker Reactions for the Rapid and Solvent‐Free One‐Pot Synthesis of Racemic α‐Aminonitrile Derivatives
Authors: Brahmachari Goutam , Banerjee Bubun
Published: August 2012

A rapid, straightforward, and efficient method for the synthesis of racemic α‐aminonitriles has been developed. This one‐pot, three‐component Strecker reaction of carbonyl compounds, amines and trimethylsilyl cyanide (TMSCN) proceeds in excellent yields in the presence of a catalytic amount of zirconium oxychloride octahydrate (ZrOCl2⋅8 H2O) under solvent‐free conditions at room temperature. The protocol is particularly convenient for both aliphatic and aromatic aldehydes, as well as cyclic ketones, in combination with primary and secondary amines. This method is also highly chemoselective. Mild reaction conditions, excellent yields, high chemoselectivity, operational simplicity, the absence of tedious separation procedures, clean reaction profiles, high atom‐economy, as well as the inexpensive and environmentally benign catalyst are the key advantages of this protocol. This Strecker reaction has also been studied in the absence of any catalyst and proceeds with good yields. The overall outcomes of these reactions in the presence and absence of catalyst are compared in the present study.
Kenaf fiber/soy protein based biocomposites modified with poly(carboxylic acid) resin
Authors: Liang Kaiwen , Gao Qiang , Shi Sheldon Q.
Published: August 2012

In this research, three different types of biocomposites were made from kenaf fiber/soy protein, kenaf fiber/DS 3530, and kenaf fiber/soy protein/DS 3530. Fourier transform infrared spectra of the biocomposites showed that there were chemical reactions among the kenaf fiber, soy flour, and BASF Acrodur resin. The hot‐pressing time had a significant effect on the flexural properties and density of both the kenaf fiber/soy flour composites and kenaf fiber/BASF Acrodur resin composites. However, the effect was opposite for the composites from 10 to 20 min of hot pressing. As the hot‐pressing time increased, the flexural properties and density increased for the kenaf fiber/soy flour composites and decreased for the other two composites with BASF Acrodur resin. BASF Acrodur resin reduced the hot‐pressing time of the biocomposites. With 28 wt % BASF Acrodur resin (on the basis of 100% solid content) as a binder and with the biocomposites hot‐pressed for 10 min, the swelling thickness and water absorption of the composites were reduced by 55 and 64%, and the flexural strength and modulus were improved by 72 and 188%, respectively. More simultaneous failures of the fiber and adhesive were observed at the fracture surface of the kenaf fiber/soy flour/BASF Acrodur resin composite. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013
Effects of supercritical carbon dioxide treatment conditions on the gas separation properties of polydimethylsiloxane hybrid membrane materials for air purification
Authors: Yu Xiangzheng , Zhang Ziyong , Rao Huaxin , Liu Fanna
Published: August 2012

A siloxane/polydimethylsiloxane (PDMS) hybrid membrane containing fluorinated side chains was prepared by a convenient and mild sol–gel process and a crosslinking reaction. The effects of the supercritical carbon dioxide (scCO2) conditions (i.e., treatment temperature, treatment time, and treatment pressure) on the permeation properties of fluorinated PDMS containing hybrid membrane were investigated. The chemical structure, microstructure, and physical performance of the membranes treated before and after were also discussed. The chemical structure of the PDMS membranes did not change with the scCO2 treatment conditions. The membranes still retained better membrane‐forming abilities, higher permeability, and selectivity than normal PDMS membranes. Compared to those of the membrane with membrane formation after scCO2 treatment, the oxygen permeability coefficient and oxygen/nitrogen separation factor of the membrane with scCO2 treatment before membrane formation were higher and were up to 7.11 × 10−8 cm3 (STP) cm/(cm2 s cmHg) and 3.27, respectively. The permeation properties of the hybrid membrane were obviously higher than those of Robeson's upper bound. The high air‐purification performance of the hybrid membrane may have been due to the introduction of fluorine atoms into PDMS membrane, and the increase in free volume resulted from the plasticizing function of the scCO2 treatment. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013
Optimal performances of ultrasound treated kenaf fiber reinforced recycled polypropylene composites as demonstrated by response surface method
Authors: Islam M. R. , Beg M. D. H. , Gupta A. , Mina M. F.
Published: August 2012

Kenaf fiber (KF) reinforced recycled polypropylene (RPP) composites were produced by melt cast method. To improve interfacial adhesion between fiber and RPP matrix, fiber surface modification was carried out by means of ultrasound treatment. Maleic anhydride grafted polypropylene (MAPP) was used as a coupling agent. Composites were examined by mechanical test, melt flow indexing test, scanning electron microscopy, thermogravimetric analysis (TGA), and differential scanning calorimetry (DSC). Water uptake analysis and accelerated weathering test were carried out to find the suitability of the composites in outdoor application. Among the raw fiber contents ranging 10−50 wt % in the composites, the maximum tensile strength (TS) was observed at 40 wt % KF loading without using MAPP. Treated KF‐based composite with MAPP promotes this maximum TS value, which is 57% higher than that of raw KF‐based composite. TGA and DSC analyses exhibit an enhancement of thermal stability in treated KF‐reinforced RPP composites with MAPP. Incorporation of MAPP in the composites shows higher activation energy, suggesting improved interfacial bonding between fibers and matrix. Response surface method was employed to demonstrate the optimal treatment parameters for TS, showing excellent agreement with the observed values. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013
Poly(ether imide)‐modified benzoxazine blends: Influences of phase separation and hydrogen bonding interactions on the curing reaction
Authors: Zhao Pei , Liang Xiaomin , Chen Jie , Ran Qichao , Gu Yi
Published: August 2012

Polymer blends of polybenzoxazine (PBZ)/poly(ether imide) (PEI) were prepared by the in situ curing reaction of benzoxazine (BZ) resin in the presence of PEI. Phase separation induced by the polymerization of BZ resin was observed. The rheological behaviors, morphologies, and their evolution process of BZ/PEI blends were investigated by rheometer and scanning electron microscope. Phase separation that took place at the early stage of the curing reaction effectively reduced the dilution effect of PEI. Fourier transform infrared (FTIR) results suggested that hydrogen bonds between PBZ and PEI existed during the whole curing process, although weakened with phase separation. The decrease of isoconversion activation energy indicated that the polymerization of BZ resin was facilitated in the presence of such kind of hydrogen‐bonding interactions. By changing the weight fraction of PEI, extensive phase separation was obtained in PBZ blends with 5 and 20 wt % of PEI, in which systems, the crosslinking density and glass transition temperature (Tg) of PBZ‐rich phase were greatly improved compared to this single PBZ system. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013
Charged membranes prepared by SPEEK of very low degree of sulfonation
Authors: Yang Wei , Zhang Jiejing , Wang Yuxin
Published: August 2012

Novel charged membranes were prepared with sulfonated poly(ether ether ketone) (SPEEK). Methylsulfonic acid was used as solvent to accommodate the very low degree of sulfonation of the SPEEK. Membranes were prepared by immersion phase inversion method, using coagulation baths of different composition and temperature. Low molecular weight and negatively charged dye molecules were used as model solutes to test the nanofiltration (NF) performance of the membranes. Higher than 93% rejection of the two dye molecules, Rose Bengal and Reactive Brilliant Red, was observed at normal operating temperature. A permeate flux as high as 497 L m−2 h−1 and higher than 90% of solute rejection at 80°C was achieved in the NF of Reactive Brilliant Red aqueous solution, in contrast to a flux of 226 L m−2 h−1 and about 78% of solute rejection at the same temperature in the case of Rose Bengal solute. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013
Drug–drug interaction study to assess the effects of atorvastatin co‐administration on pharmacokinetics and anti‐thrombotic properties of cilostazol in male Wistar rats
Authors: Vats Rahul , Varanasi Kanthikiran V. S. , Arla Rambabu , Veeraraghvan Sridhar , Rajak Shraddha
Published: August 2012

Cilostazol (CLZ) and atorvastatin (ATV) are often co‐prescribed to treat conditions such as peripheral arterial disease. In the present study, the drug–drug interaction potential of multi‐dose ATV co‐administration with CLZ on both pharmacokinetics and the anti‐thrombotic property of CLZ is demonstrated. The pharmacokinetic parameters of CLZ (6 mg/kg, twice daily) were determined in male Wistar rats after 7 days co‐administration with ATV (5 mg/kg, once daily) in order to assess the interaction potential between CLZ and ATV on chronic treatment. In vitro metabolic inhibition and everted gut sac studies were conducted to elucidate the mechanism of this interaction. Pharmacodynamic drug–drug interaction was evaluated on anti‐thrombotic models including time to occlusion, platelet aggregation and rat tail bleeding time. A validated LC‐MS/MS method was employed simultaneously to quantify both ATV and CLZ in rat plasma matrix. A statistically significant increase in systemic exposure (Cssmax by ~1.75 fold; AUC by ~3.0 fold) to CLZ was observed in ATV pre‐treated rats. In vitro metabolism studies using liver microsomes (RLM and HLM) demonstrated statistically significant inhibition of CLZ metabolism when co‐incubated with ATV. No change in apparent permeability of CLZ was observed in the presence of ATV. Atorvastatin showed a significant delay in artery occlusion time without altering CLZ's bleeding time and platelet aggregation profile. Collectively the results of these studies provide metabolic insight into the nature of drug–drug interaction between the selected drugs. Co‐administration with ATV influences the pharmacokinetics and anti‐thrombotic property of CLZ. A thorough clinical investigation is required before extrapolation of data to humans. Copyright © 2012 John Wiley & Sons, Ltd.
Identification of CYP isozymes involved in benzbromarone metabolism in human liver microsomes
Authors: Kobayashi Kaoru , Kajiwara Eri , Ishikawa Masayuki , Oka Hidenobu , Chiba Kan
Published: August 2012

Benzbromarone (BBR) is metabolized to 1′‐hydroxy BBR and 6‐hydroxy BBR in the liver. 6‐Hydroxy BBR is further metabolized to 5,6‐dihydroxy BBR. The aim of this study was to identify the CYP isozymes involved in the metabolism of BBR to 1′‐hydroxy BBR and 6‐hydroxy BBR and in the metabolism of 6‐hydroxy BBR to 5,6‐dihydroxy BBR in human liver microsomes. Among 11 recombinant P450 isozymes examined, CYP3A4 showed the highest formation rate of 1′‐hydroxy BBR. The formation rate of 1′‐hydroxy BBR significantly correlated with testosterone 6β‐hydroxylation activity in a panel of 12 human liver microsomes. The formation of 1′‐hydroxy BBR was completely inhibited by ketoconazole in pooled human liver microsomes. On the other hand, the highest formation rate of 6‐hydroxy BBR was found in recombinant CYP2C9. The highest correlation was observed between the formation rate of 6‐hydroxy BBR and diclofenac 4′‐hydroxylation activity in 12 human liver microsomes. The formation of 6‐hydroxy BBR was inhibited by tienilic acid in pooled human liver microsomes. The formation of 5,6‐dihydroxy BBR from 6‐hydroxy BBR was catalysed by recombinant CYP2C9 and CYP1A2. The formation rate of 5,6‐dihydroxy BBR was significantly correlated with diclofenac 4′‐hydroxylation activity and phenacetin O‐deethylation activity in 12 human liver microsomes. The formation of 5,6‐dihydroxy BBR was inhibited with either tienilic acid or α‐naphthoflavone in human liver microsomes. These results suggest that (i) the formation of 1′‐hydroxy BBR and 6‐hydroxy BBR is mainly catalysed by CYP3A4 and CYP2C9, respectively, and (ii) the formation of 5,6‐dihydroxy BBR is catalysed by CYP2C9 and CYP1A2 in human liver microsomes. Copyright © 2012 John Wiley & Sons, Ltd.
Comparative pharmacokinetic study of paclitaxel and docetaxel in streptozotocin‐induced diabetic rats
Authors: Lee Joo Hyun , Lee Areum , Oh Ju‐Hee , Lee Young‐Joo
Published: August 2012

The pharmacokinetics of paclitaxel and docetaxel were compared in diabetic rats induced by streptozotocin (DMIS rats) and the impact of altered expression of cytochrome P450 3A (Cyp3A) and P‐glycoprotein (P‐gp) in the diabetic state. The pharmacokinetics of paclitaxel and docetaxel were determined after intravenous (5 mg/kg) and oral (30 and 40 mg/kg, respectively) administration to both groups and the mRNA expression levels of Cyp3A isozymes and Mdr1a and Mdr1b in the liver and small intestine were determined in control and DMIS rats. After intravenous administration, the AUC and clearance of paclitaxel and docetaxel were not significantly different in DMIS vs control rats. After oral administration, the AUC and Cmax of paclitaxel in DMIS rats were significantly greater than those in the control rats, whereas those of docetaxel was not changed significantly. The mRNA expression levels of hepatic Cyp3A1, Cyp3A9 and Mdr1b were significantly increased in DMIS compared with the control rats. In the intestine, Cyp3A62 expression decreased in the DMIS rats compared with the controls. Thus the pharmacokinetic changes of taxanes observed in the DMIS rats were attributed to changes in P‐gp and Cyp3A, predominant factors that control the absorption of paclitaxel and docetaxel, respectively. It seemed that there were different susceptibilities to intestinal P‐gp and Cyp3A between the two taxanes. Copyright © 2012 John Wiley & Sons, Ltd.
Photosynthetic efficiency and rate of CO2 assimilation by Arthrospira (Spirulina) platensis continuously cultivated in a tubular photobioreactor
Authors: Matsudo Marcelo Chuei , Bezerra Raquel Pedrosa , Sato Sunao , Converti Attilio , de Carvalho João Carlos Monteiro
Published: August 2012

Similar to other photosynthetic microorganisms, the cyanobacterium Arthrospira platensis can be used to produce pigments, single cell proteins, fatty acids (which can be used for bioenergy), food and feed supplements, and biofixation of CO2. Cultivation in a specifically designed tubular photobioreactor is suitable for photosynthetic biomass production, because the cultivation area can be reduced by distributing the microbial cells vertically, thus avoiding loss of ammonia and CO2. The aim of this study was to investigate the influence of light intensity and dilution rate on the photosynthetic efficiency and CO2 assimilation efficiency of A. platensis cultured in a tubular photobioreactor in a continuous process. Urea was used as a nitrogen source and CO2 as carbon source and for pH control. Steady‐state conditions were achieved in most of the runs, indicating that continuous cultivation of this cyanobacterium in a tubular photobioreactor could be an interesting alternative for the large‐scale fixation of CO2 to mitigate the greenhouse effect while producing high protein content biomass.
Efficient reversal of phiC31 integrase recombination in mammalian cells
Authors: Farruggio Alfonso P. , Chavez Christopher L. , Mikell Carlos L. , Calos Michele P.
Published: August 2012

Over the past decade, the integrase enzyme from phage phiC31 has proven to be a useful genome engineering tool in a wide variety of species, including mammalian cells. The enzyme efficiently mediates recombination between two distinct sequences, attP and attB, producing recombinant product sites, attL and attR. The reaction proceeds exclusively in a unidirectional manner, because integrase is unable to synapse attL and attR. To date, use of phiC31 integrase has been limited to attP × attB recombination. The factor needed for the reverse reaction – the excisionase or recombination directionality factor (RDF) – was identified recently and shown to function in vitro and in bacterial cells. To determine whether the phiC31 RDF could also function in mammalian cells, we cloned and tested several vectors that permit assessment of phiC31 RDF activity in mammalian environments. In the human and mouse cell lines tested (HeLa, HEK293, and NIH3T3), we observed robust RDF activity, using plasmid and/or genomic assays. This work is the first to demonstrate attL–attR serine integrase activity in mammalian cells and validates phiC31 RDF as a new tool that will enable future studies to take advantage of phiC31 integrase recombination in the forward or reverse direction.
Psychopathic Traits and Their Association with Adjustment Problems in Girls
Authors: Charles Nora E. , Acheson Ashley , Mathias Charles W. , Michael Furr R. , Dougherty Donald M.
Published: August 2012

Psychopathic traits, and specifically callous‐unemotional (CU) traits, are associated with a variety of adverse outcomes in adolescence and adulthood. The majority of research in this area has focused on men and boys, though there is some evidence that psychopathy is expressed differently in girls and women. Accordingly, the purpose of this study was to test if the relationships of callous–unemotional (CU) traits with adjustment differed between girls and boys at risk for antisocial behavior. The sample was composed of children whose biological father had past or current alcohol or drug problems. A total of 234 children (116 boys, 118 girls; ages 10‐12) were rated by their parent or guardian on CU traits and overall adjustment. Boys were generally rated higher on measures of CU traits; however, these traits were more prominently related to adjustment problems among girls. These results suggest that expression of psychopathic traits may have more negative effects on adjustment for girls than boys. One possible mechanism by which CU traits could be impacting adjustment in girls is by impairing interpersonal relationships. Copyright © 2012 John Wiley & Sons, Ltd.
Chemical Biology for Understanding Matrix Metalloproteinase Function
Authors: Knapinska Anna , Fields Gregg B.
Published: August 2012

The matrix metalloproteinase (MMP) family has long been associated with normal physiological processes such as embryonic implantation, tissue remodeling, organ development, and wound healing, as well as multiple aspects of cancer initiation and progression, osteoarthritis, inflammatory and vascular diseases, and neurodegenerative diseases. The development of chemically designed MMP probes has advanced our understanding of the roles of MMPs in disease in addition to shedding considerable light on the mechanisms of MMP action. The first generation of protease‐activated agents has demonstrated proof of principle as well as providing impetus for in vivo applications. One common problem has been a lack of agent stability at nontargeted tissues and organs due to activation by multiple proteases. The present review considers how chemical biology has impacted the progress made in understanding the roles of MMPs in disease and the basic mechanisms of MMP action.
Direct Detection of Key Intermediates in Rhodium(I)‐Catalyzed [2+2+2] Cycloadditions of Alkynes by ESI‐MS
Authors: Parera Magda , Dachs Anna , Solà Miquel , Pla‐Quintana Anna , Roglans Anna
Published: August 2012

The mechanism of the Rh‐catalysed [2+2+2] cycloaddition reaction of diynes with monoynes has been examined using ESI‐MS and ESI‐CID‐MS analysis. The catalytic system used consisted of the combination of a cationic rhodium(I) complex with bisphosphine ligands, which generates highly active complexes that can be detected by ESI(+) experiments. ESI‐MS on‐line monitoring has allowed the detection for the first time of all of the intermediates in the catalytic cycle, supporting the mechanistic proposal based mainly on theoretical calculations. For all ESI‐MS experiments, the structural assignments of ions are supported by tandem mass spectrometry analyses. Computer model studies based on density functional theory (DFT) support the structural proposal made for the monoyne insertion intermediate. The collective studies provide new insight into the reactivity of cationic rhodacyclopentadienes, which should facilitate the design of related rhodium‐catalysed CC couplings.
Lanosterol Biosynthesis: The Critical Role of the Methyl‐29 Group of 2,3‐Oxidosqualene for the Correct Folding of this Substrate and for the Construction of the Five‐Membered D Ring
Authors: Hoshino Tsutomu , Chiba Akifumi , Abe Naomi
Published: August 2012

Lanosterol synthase catalyzes the polycyclization reaction of (3S)‐2,3‐oxidosqualene (1) into tetracyclic lanosterol 2 by folding 1 in a chair‐boat‐chair‐chair conformation. 27‐Nor‐ and 29‐noroxidosqaulenes (7 and 8, respectively) were incubated with this enzyme to investigate the role of the methyl groups on 1 for the polycyclization cascade. Compound 7 afforded two enzymatic products, namely, 30‐norlanosterol (12) and 26‐normalabaricatriene (13; 12/13 9:1), which were produced through the normal chair‐boat‐chair‐chair conformation and an atypical chair‐chair‐boat conformation, respectively. Compound 8 gave two products 14 and 15 (14/15 4:5), which were generated by the normal and the unusual polycyclization pathways through a chair‐chair‐boat‐chair conformation, respectively. It is remarkable that the twist‐boat structure for the B‐ring formation was changed to an energetically favored chair structure for the generation of 15. Surprisingly, 14 and 15 consisted of a novel 6,6,6,6‐fused tetracyclic ring system, thus differing from the 6,6,6,5‐fused lanosterol skeleton. Together with previous results, we conclude that the methyl‐29 group is critical to the correct folding of 1, with lesser contributions from the other branched methyl groups, such as methyl‐26, ‐27, and ‐28. Furthermore, we demonstrate that the methyl‐29 group has a crucial role in the formation of the five‐membered D ring of the lanosterol scaffold.
ChemInform Abstract: Revisiting the Polyoxometalate‐Based Late‐Transition‐Metal‐Oxo Complexes: The “Oxo Wall” Stands.
Authors: Hill Craig L. , et al. et al.
Published: August 2012

New XRD data of the previously published K14[P2W19O69(H2O)] (I), the 17O NMR spectrum of (Bu4N)7[PW11O39], a careful titration of “K7H2 [Au(O)(OH2)P2W20O70 (OH2)2]” followed by 31P NMR spectroscopy, and a new X‐ray crystal structure of the compound reformulated as K12 [PdWO(H2O)(PW9O34)2] (II) are reported.
ChemInform Abstract: Neutron Diffraction Study of Unusual Phase Separation in the Antiperovskite Nitride Mn3ZnN.
Authors: Sun Ying , Wang Cong , Huang Qingzhen , Guo Yanfeng , Chu Lihua , Arai Masao , Yamaura Kazunari
Published: August 2012

The title compound is characterized by neutron diffraction at temperatures between 50 and 295 K.
ChemInform Abstract: Eleven New Compounds in the Ln—Cd—Ge Systems (Ln: Pr, Nd, Sm, Gd—Yb; Y). Crystal Chemistry of the Ln2CdGe2 Series.
Authors: Guo Sheng‐Ping , Meyers John J. , Tobash Paul H. , Bobev Svilen
Published: August 2012

The title compounds are synthesized from mixtures of the elements in the ratio Ln:Cd:Ge = 1:25:1 (alumina crucible, 973 K, 2 d) and characterized by single crystal XRD and TB‐LMTO electronic structure calculations.
ChemInform Abstract: The Spectroscopy Investigation of ZnWO4:Tm2+ Single Crystal.
Authors: Yang Fugui , Tu Chaoyang
Published: August 2012

A single crystal of the title compound is grown by the Czochralski method and characterized by XRD, refractive index, absorption, and fluorescence measurements to explore its potential 2 μm laser properties.
ChemInform Abstract: Phase Relationships in the BaO—Ga2O3—Ta2O5 System and the Structure of Ba6Ga21TaO40.
Authors: Cao Jiang , Yu Xiaodi , Kuang Xiaojun , Su Qiang
Published: August 2012

Phase relationships in the title system at 1200 °C are determined by powder XRD.
ChemInform Abstract: TM7TM′6B8 (TM: Ta, Nb; TM′: Ru, Rh, Ir): New Compounds with [B6] Ring Polyanions.
Authors: Grin Yuri , et al. et al.
Published: August 2012

The title compounds are prepared by arc‐melting of the elements followed by annealing at 1500—1650 °C for 3 or 4 d under argon.
ChemInform Abstract: Cationic Cryptand Complexes of Tin(II).
Authors: Avery Jessica C. , Hanson Margaret A. , Herber Rolfe H. , Bladek Kamila J. , Rupar Paul A. , Nowik Israel , Huang Yining , Baines Kim M.
Published: August 2012

The new tin [2.2.2]cryptand complexes are characterized by single crystal XRD, NMR, Raman, and Moessbauer spectroscopy, and mass spectrometry.
ChemInform Abstract: Redox‐Active Metal‐Centered Oxalato Phosphate Open Framework Cathode Materials for Lithium Ion Batteries.
Authors: Nagarathinam Mangayarkarasi , Saravanan Kuppan , Phua Eunice Jia Han , Reddy M. V. , Chowdari B. V. R. , Vittal Jagadese J.
Published: August 2012

Metal organic phosphate open framework materials (III), (V), and (VII) are investigated as hybrid cathode materials for lithium ion batteries.
ChemInform Abstract: Syntheses and Properties of a Series of Chromium Vanadates ACrV2O7 (A: Na, K, Rb, Cs) with Layered Structure.
Authors: Wang Yonggang , Liang Jie , Wen Ting , Li Kuo , Wang Yingxia , Li Guobao , Liao Fuhui , Lin Jianhua
Published: August 2012

The title compounds, K0.5Rb0.5CrV2O7, and Rb0.5Cs0.5CrV2O7 are prepared by solid state reaction of stoichiometric mixtures of A2Cr2O7 and V2O5 at 430—550 °C.
ChemInform Abstract: (UO2)2 [UO4(trz)2](OH)2: A U(VI) Coordination Intermediate Between a Tetraoxido Core and a Uranyl Ion with Cation—Cation Interactions.
Authors: Weng Zhehui , Wang Shuao , Ling Jie , Morrison Jessica M. , Burns Peter C.
Published: August 2012

(UO2)2 [UO4(trz)2](OH)2 (trz: 1,2,4‐triazole) is obtained under mild solvothermal conditions by reaction of uranyl acetate and 1,2,4‐triazole in a mixed solution of EtOH, MeCN, and H2O (autoclave, 150 °C, 4 d, 42% yield).
ChemInform Abstract: Synthesis of a Uranyl Persulfide Complex and Quantum Chemical Studies of Formation and Topologies of Hypothetical Uranyl Persulfide Cage Clusters.
Authors: Grant Daniel J. , Weng Zhehui , Jouffret Laurent J. , Burns Peter C. , Gagliardi Laura
Published: August 2012

Na4 [(UO2)(S2)3](MeOH)8 is obtained from a MeOH solution containing UO2(O‐Tf)2, Na2S, S, and NaOH at room temperature (20% yield).
ChemInform Abstract: Cation—Cation Interactions Between Neptunyl(VI) Units.
Authors: Wang Shuao , Diwu Juan , Alekseev Evgeny V. , Jouffret Laurent J. , Depmeier Wulf , Albrecht‐Schmitt Thomas E.
Published: August 2012

Colorless crystals of Na[(NpO2)4B15O24 (OH)5(H2O)](ClO4)·0.75H2O are prepared by reaction of NpO2(ClO4)2 and NaClO4 in a boric acid flux (autoclave, 220 °C, 3 d).
ChemInform Abstract: Room‐Temperature Synthesis, Hydrothermal Recrystallization, and Properties of Metastable Stoichiometric FeSe.
Authors: Nitsche F. , Goltz T. , Klauss H.‐H. , Isaeva A. , Mueller U. , Schnelle W. , Simon P. , Doert Th. , Ruck M.
Published: August 2012

Metastable FeSe is synthesized by diffusion‐controlled precipitation from Li2Se and FeI2 powders at room temperature using water as diffusion medium (Ar, H‐shaped tube, 40 d) and by hydrothermal recrystallization from aqueous solutions of Li2Se and FeI2 (autoclave, 200 °C, 3 d).
ChemInform Abstract: K4Fe4P5O20: A New Mixed Valence Microporous Compound with Elliptical Eight‐Ring Channels.
Authors: He Zhangzhen , Zhang Weilong , Cheng Wendan , Okazawa Atsushi , Kojima Norimichi
Published: August 2012

Single crystals of the title compound are synthesized by solid state reaction of K2CO3, Fe2O3, NH4H2PO4, and KF (alumina crucible, 1050 °C, 10 h).
ChemInform Abstract: A Se19 Homocycle Complexed by Two Copper(I) Ions.
Authors: Schaefer Julia , Steffani Alberto , Plattner Dietmar A. , Krossing Ingo
Published: August 2012

Compound (I) reacts with freshly prepared red selenium to form compound (III) and (IV), which contain the first structurally characterized E19 ring of any element E so far.
ChemInform Abstract: Bis[tetraruthenium(IV)]‐Containing Polyoxometalates: [{RuIV4O6 (H2O) 9}2Sb2W20O68 (OH)2]4‐ and [{RuIV4O6 (H2O)9}2{Fe (H2O)2}2{β‐TeW9 O33}2H]‐.
Authors: Kalinina Irina V. , Izarova Natalya V. , Kortz Ulrich
Published: August 2012

The new compounds (III) and (V) crystallize in the triclinic space group P$\bar 1$ with Z = 1 (single crystal XRD).
ChemInform Abstract: High‐Pressure Synthesis, Crystal Structure, and Properties of BiPd2O4 with Pd2+ and Pd4+ Ordering and PbPd2O4.
Authors: Yi Wei , Matsushita Yoshitaka , Tanaka Masahiko , Belik Alexei A.
Published: August 2012

The title compounds are prepared from stoichiometric mixtures of Bi2O3, PdO, and KClO4 (BiPd2O4), or PbO2 and PdO (PbPd2O4) in Au capsules at 6 GPa and 1500 K (2 h).
ChemInform Abstract: FeCl3·6H2O and TfOH as Catalysts for Allylic Amination Reaction: A Comparative Study.
Authors: Trillo Paz , Baeza Alejandro , Najera Carmen
Published: August 2012

Both the Lewis acid as well as the Broensted acid are suitable catalysts for allylic amination reactions.
ChemInform Abstract: Highly Efficient Synthesis of Novel Morita—Baylis—Hillman Adducts from Activated Ketones Using a DABCO‐Based Hydroxy Ionic Liquid (HIL) as a Recyclable Catalyst‐Solvent.
Authors: Khalafi‐Nezhad Ali , Mohammadi Somayeh
Published: August 2012

The ionic liquid works best in the presence of DBU and allows the access to a broad spectrum of highly functionalized products which are of biological interest.
ChemInform Abstract: 2‐Aminothiophenes as Building Blocks in Heterocyclic Synthesis: Synthesis and Antimicrobial Evaluation of a New Class of Pyrido[1,2‐a]thieno[3,2‐e]pyrimidine, Quinoline and Pyridin‐2‐one Derivatives.
Authors: Behbehani Haider , Ibrahim Hamada Mohamed , Makhseed Saad , Elnagdi Mohamed H. , Mahmoud Huda
Published: August 2012

The reactivity of the amino group in aminothiophenes (I) is exploited to prepare the cyanoacetamides (III) which are utilized as precursors to a variety of novel thiophene derivatives and dyes.
ChemInform Abstract: Cyclization of 1,6‐Enynes Catalyzed by Gold Nanoparticles Supported on TiO2: Significant Changes in Selectivity and Mechanism, as Compared to Homogeneous Au‐Catalysis.
Authors: Gryparis Charis , Efe Christina , Raptis Christos , Lykakis Ioannis N. , Stratakis Manolis
Published: August 2012

First examples of a heterogeneous Au‐catalyzed cyclization of 1,6‐enynes are reported.
ChemInform Abstract: Enantioselective Cyclopropanation of Enals by Oxidative N‐Heterocyclic Carbene Catalysis.
Authors: Biswas Anup , De Sarkar Suman , Tebben Ludger , Studer Armido
Published: August 2012

α,β‐Unsaturated aldehydes are activated by a carbene‐catalyzed redox pathway to generate the corresponding acyl azolium intermediates, which react with sulfur ylides and an alcohol to give cyclopropanecarboxylic acid esters.
ChemInform Abstract: Development of Manganese(VI) Oxidizing Agents Soluble in Organic Solvents.
Authors: Ellis Rhys , Lee Kee‐Han , Ainsworth Matthew , Kerr Alexander , Viseux Eddy M. E.
Published: August 2012

The novel agent BAPM is prepared and successfully applied to the oxidation of alcohols, aniline, and 2‐aminothiophenol.
ChemInform Abstract: Oxidation of Alkyl Aromatics to Ketones by tert‐Butyl Hydroperoxide on Manganese Dioxide Catalyst.
Authors: Burange Anand S. , Kale Sandip R. , Jayaram Radha V.
Published: August 2012

Various cyclic systems containing active methylene sites are converted to ketones with a high level of selectivity under the optimized conditions A).
ChemInform Abstract: Dihydroxylation of Olefins Catalyzed by Zeolite‐Confined Osmium(0) Nanoclusters: An Efficient and Reusable Method for the Preparation of 1,2‐cis‐Diols.
Authors: Metin Oender , Alp Nurdan Alcan , Akbayrak Serdar , Bicer Abdullah , Gueltekin Mehmet Serdar , Oezkar Saim , Bozkaya Ugur
Published: August 2012

A novel heterogeneous osmium catalyst is prepared and successfully applied for the dihydroxylation of different alkenes.
ChemInform Abstract: Development of Catalysts for the Stereoselective Hydrogenation of α,β‐Unsaturated Ketones.
Authors: Maurer Frauke , Huch Volker , Ullrich Angelika , Kazmaier Uli
Published: August 2012

The new iridium complex is found to be an efficient catalyst to produce various α‐substituted ketones with high enantioselectivity.
ChemInform Abstract: Suzuki—Miyaura Cross‐Coupling Reactions of Potassium Boc‐Protected Aminomethyltrifluoroborate with Aryl and Hetaryl Mesylates.
Authors: Molander Gary A. , Shin Inji
Published: August 2012

The title reaction allows an efficient access to a wide range of aminomethylarenes.
ChemInform Abstract: Regio‐ and Stereoselectivity in the Reactions of Organometallic Reagents with an Electron‐Deficient and an Electron‐Rich Vinyloxirane: Applications for Sequential Bis‐allylic Substitution Reactions in the Generation of Vicinal Stereogenic Centers.
Authors: Dieter R. Karl , Huang Yaxin , Guo Fenghai
Published: August 2012

Under appropriate conditions, the reaction of vinyloxiranes (I) and (IX) with organometallic reagents can take place with high regio‐ and stereoselectivity.
ChemInform Abstract: Preparation of Polystyrene‐Supported Lewis Acidic Fe(III) Ionic Liquid and Its Application in Catalytic Conversion of Carbon Dioxide.
Authors: Gao Jian , Song Qing‐Wen , He Liang‐Nian , Liu Chang , Yang Zhen‐Zhen , Han Xu , Li Xue‐Dong , Song Qing‐Chuan
Published: August 2012

Terminal epoxides, aziridines, and a propargylic amine are efficiently carboxylated under neat conditions in the presence of the title catalyst to give cyclic carbonates and oxazolidinones, correspondingly.
ChemInform Abstract: Regioselective, Borinic Acid‐Catalyzed Monoacylation, Sulfonylation and Alkylation of Diols and Carbohydrates: Expansion of Substrate Scope and Mechanistic Studies.
Authors: Lee Doris , Williamson Caitlin L. , Chan Lina , Taylor Mark S.
Published: August 2012

The method can be generally applied to the monotosylation of pyranoside derivatives bearing three secondary hydroxyl groups.
ChemInform Abstract: Zinc Titanate Nanopowder: An Advanced Nanotechnology Based Recyclable Heterogeneous Catalyst for the One‐Pot Selective Synthesis of Self‐Aggregated Low‐Molecular Mass Acceptor—Donor—Acceptor—Acceptor Systems and Acceptor—Donor—Acceptor Triads.
Authors: Das Paramita , Butcher Ray J. , Mukhopadhyay Chhanda
Published: August 2012

The ZnTiO3‐catalyzed multicomponent reaction of ketones (I) with aldehydes (II) and malononitrile (III) under reflux leads to aromatic dinitriles (IV), whilst the reaction at room temperature affords trinitriles (V).
ChemInform Abstract: Iridium Catalyzed Enantioselective Hydrogenation of α‐Alkoxy and β‐Alkoxy Vinyl Ethers.
Authors: Zhu Ye , Burgess Kevin
Published: August 2012

A variety of functionalized acid‐sensitive vinyl ethers is successfully hydrogenated in the presence of a chiral Ir—N‐carbene—oxazoline complex (ICOC).
ChemInform Abstract: A Highly Diastereoselective Decarboxylative Mannich Reaction of β‐Keto Acids with Optically Active N‐Sulfinyl α‐Imino Esters.
Authors: Yang Cui‐Feng , Shen Chen , Wang Jian‐Yong , Tian Shi‐Kai
Published: August 2012

It provides an efficient approach to optically active .gamma‐oxo‐α‐amino esters and acids.
ChemInform Abstract: Steric Tuning of C2‐Symmetric Chiral N‐Heterocyclic Carbene in Gold‐Catalyzed Asymmetric Cyclization of 1,6‐Enynes.
Authors: Yamada Ken‐ichi , Matsumoto Yasumasa , Selim Khalid B. , Yamamoto Yasutomo , Tomioka Kiyoshi
Published: August 2012

Eight chiral NHC‐gold(I) complexes are prepared and investigated.
ChemInform Abstract: Asymmetric α‐Oxyacylation of Cyclic Ketones.
Authors: Smithen Deborah A. , Mathews Christopher J. , Tomkinson Nicholas C. O.
Published: August 2012

Various N‐alkyl‐O‐acyl hydroxylamines are synthesized and their application to the title reaction with different cyclic ketones are investigated.
ChemInform Abstract: mpg‐C3N4 as a Solid Base Catalyst for Knoevenagel Condensations and Transesterification Reactions.
Authors: Su Fangzheng , Antonietti Markus , Wang Xinchen
Published: August 2012

In the Knoevenagel condensation of (I) with (IIa) the catalyst is recycled and used in five consecutive runs without loss of catalytic activity.
ChemInform Abstract: A Novel Hydrophobic Fluorous Ionic for Ligand‐Free Mizoroki—Heck Reaction.
Authors: Gaikwad Dipak S. , Park YoonKook , Pore Dattaprasad M.
Published: August 2012

An efficient method is developed by in situ formation of Pd‐nanoparticles.
ChemInform Abstract: Mesoporous Nickel Hydroxyapatite Nanocomposition for Microwave‐Assisted Henry Reaction.
Authors: Neelakandeswari N. , Sangami G. , Emayavaramban P. , Karvembu R. , Dharmaraj N. , Kim Hak Yong
Published: August 2012

The catalyst is prepared and used for the title reaction of aromatic aldehydes with nitromethane.
ChemInform Abstract: Synthesis of Acridines and Persubstituted Phenols from Cyclobutenones and Active Methylene Ketones.
Authors: Han Xiao‐Dan , Zhao Yu‐Long , Meng Jia , Ren Chuan‐Qing , Liu Qun
Published: August 2012

Base‐mediated treatment of cyclobutenones with active methylene ketones provides a new and regioselective approach to persubstituted phenols.
ChemInform Abstract: Simple Preparation of β‐Amino Alcohols Possessing a tert‐Butyl Group at the α‐Carbon.
Authors: Zacharia James T. , Tanaka Takanori , Uesaka Yumiko , Hayashi Masahiko
Published: August 2012

Among the title compounds, derivatives (Ic) and (Id) which bear the tert‐butyl group at the α‐carbon, are shown to be efficient catalysts for the asymmetric addition of diethylzinc to benzaldehyde.
ChemInform Abstract: A Biocatalytic Approach for Regioselective Monoacetylation of 3‐Aryloxy‐1,2‐propanediols by Porcine Pancreatic Lipase.
Authors: Meena Vachan Singh , Banerjee U. C.
Published: August 2012

Optimized reaction conditions are examined for the lipase‐catalyzed regioselective monoacetylation of 3‐aryloxy‐1,2‐propanediols (I).
ChemInform Abstract: Enantioselective Organocatalytic Michael Addition of 2‐Arylacetates and 2‐Arylacetonitriles Having an Electron‐Withdrawing Group to α,β‐Unsaturated Aldehydes.
Authors: Seo Seung Woo , Kim Sung‐Gon
Published: August 2012

Optimized conditions render possible the preparation of various target compounds whose functionalities allow transformation to biologically important substances.
ChemInform Abstract: Copper(0)‐Catalyzed Aerobic Oxidative Synthesis of Imines from Amines under Solvent‐Free Conditions.
Authors: Patil Rajendra D. , Adimurthy Subbarayappa
Published: August 2012

The reaction proceeds smoothly for a variety of aromatic and aliphatic amines using air as terminal oxidant.
ChemInform Abstract: Sulfuric Acid Catalyzed Addition of β‐Dicarbonyl Compounds to Alcohols under Conventional Heating and Microwave‐Assisted Conditions.
Authors: Xia Fei , Zhao Zheng Le , Liu Pei Nian
Published: August 2012

The investigation of a broad spectrum reveals that there is no advantage of a microwave version compared to conventional conditions.
ChemInform Abstract: Ruthenium(II) Carbonyl Complexes Containing Benzhydrazone Ligands: Synthesis, Structure and Facile One‐Pot Conversion of Aldehydes to Amides.
Authors: Prabhu Rupesh Narayana , Ramesh Rengan
Published: August 2012

A newly developed catalyst is successfully applied to the synthesis of the title amides (II).
ChemInform Abstract: Copper‐Catalyzed Cyanation of Benzyl Chlorides with Non‐Toxic K4[Fe(CN)6].
Authors: Ren Yunlai , Dong Chuanhua , Zhao Shuang , Sun Yanpei , Wang Jianji , Ma Junying , Hou Chaodong
Published: August 2012

The method avoids the use of a non‐toxic cyanide source and metal catalysis.
ChemInform Abstract: Palladium Nanoparticles Supported on Silicadiphenyl Phosphinite (SDPP) as Efficient Catalyst for Mizoroki—Heck and Suzuki—Miyaura Coupling Reactions.
Authors: Iranpoor Nasser , Firouzabadi Habib , Motevalli Somayeh , Talebi Mohsen
Published: August 2012

A cheap and convenient method for the phosphorylation of silica gel is developed and the material is used to immobilize Pd(0)‐nanoparticles.
ChemInform Abstract: A Highly Efficient Catalyst‐Free Protocol for C—H Bond Activation: Sulfamidation of Alkyl Aromatics and Aldehydes.
Authors: Borah Arun Jyoti , Phukan Prodeep
Published: August 2012

Amination of toluene derivatives with the compound (II) fails in Et‐O‐Ac, while the reaction takes place under solvent‐free conditions [cf.
ChemInform Abstract: A One‐Pot Regioselective Synthetic Route to Vinyl Sulfones from Terminal Epoxides in Aqueous Media.
Authors: Chawla Ruchi , Kapoor Ritu , Singh Atul K. , Yadav Lal Dhar S.
Published: August 2012

The reaction of 2‐alkylepoxides with sulfinates (II) leads selectively to sulfones (IV), whilst the analogous reaction of 2‐arylepoxides affords a mixture of two regioisomers (III) and (IV).
ChemInform Abstract: Efficient Synthesis of Methyl Carbamate via Hofmann Rearrangement in the Presence of TsNBr2.
Authors: Borah Arun Jyoti , Phukan Prodeep
Published: August 2012

The reaction is successful for aromatic and aliphatic amides in the presence of primary alcohols (II), especially MeOH.
ChemInform Abstract: An Efficient Synthesis of a Potent Antiinflammatory Agent, Viscolin, and Its Inducible Nitric Oxide Synthase Inhibitory Activity.
Authors: Kuo Ping‐Chung , Chen Yi‐Hsien , Leu Yann‐Lii , Huang Chieh‐Hung , Liao Yu‐Ren , Lee E‐Jian , Yang Mei‐Lin , Wu Tian‐Shung
Published: August 2012

A more efficient procedure for the large‐scale production of viscolin (VIII) is presented.
ChemInform Abstract: One‐Pot Synthesis of Unsymmetrical Benzils from Aryl Methyl Ketones and Arenes in the Presence of Selenous Acid Catalyzed by p‐Toluenesulfonic Acid Monohydrate.
Authors: Kharkongor Icydora , Rohman Md. Rumum , Myrboh Bekington
Published: August 2012

A modified process is presented for the oxidative coupling of acetophenones with weakly or unactivated arenes to produce the synthetically important benzil structures.
ChemInform Abstract: Iodine Mediated/Broensted Acid‐Catalyzed Dimerization of Vinylarenes: A Tandem Reaction Through Ritter Trapping to Produce N‐(4‐Iodo‐1,3‐diarylbutyl) Acetamides.
Authors: Huang Jing‐Mei , Ye Zhi‐Jun , Chen Dong‐Song , Zhu Hong
Published: August 2012

The new title one‐step reaction is developed by using readily available starting materials.
ChemInform Abstract: Design, Synthesis, and Biological Evaluation of Bromophenol Derivatives as Protein Tyrosine Phosphatase 1B Inhibitors.
Authors: Jiang Bo , Shi Dayong , Cui Yongchao , Guo Shuju
Published: August 2012

A variety of bromophenol derivatives with bicyclic, tricyclic or tetracyclic scaffold is synthesized and evaluated for protein tyrosine phosphatase 1B inhibitory activity.
ChemInform Abstract: Simple and Inexpensive Threonine‐Based Organocatalysts as Highly Active and Recoverable Catalysts for Large‐Scale Asymmetric Direct Stoichiometric Aldol Reactions on Water.
Authors: Wu Chuanlong , Long Xiaoqin , Li Shi , Fu Xiangkai
Published: August 2012

A newly designed catalyst is successfully applied to the title reaction which can be performed on a large‐scale under these conditions.
ChemInform Abstract: C2‐Symmetric Proline‐Derived Tetraamine as Highly Effective Catalyst for Direct Asymmetric Michael Addition of Ketones to Chalcones.
Authors: Ma Shijun , Wu Lulu , Liu Ming , Wang Yongmei
Published: August 2012

For the first time this type of catalyst is effectively applied to the title addition reaction under mild conditions.
ChemInform Abstract: Synthesis of Unsymmetrically Substituted 2,2′‐Dihydroxy‐1,1′‐biaryl Derivatives Using Organic‐Base‐Catalyzed Ferrier‐Type Rearrangement as the Key Step.
Authors: Terada Masahiro , Dan Katsunori
Published: August 2012

An enantioselective reaction in the presence of a chiral base leads to low yields and e.e.
ChemInform Abstract: Conformationally Restricted Naphthalene Derivatives Type isoCombretastatin A‐4 and isoErianin Analogues: Synthesis, Cytotoxicity and Antitubulin Activity.
Authors: Provot Olivier , et al. et al.
Published: August 2012

Three new classes of inhibitors of tubulin polymerization, based on the skeleton of dihydronapthalenes, tetrahydronapthalenes, and naphthalenes, are synthesized by a convergent strategy.
ChemInform Abstract: One‐Pot Synthesis of Indene Through Copper(I)‐Catalyzed Three‐Components Coupling and Cyclization Reaction.
Authors: Wang Xiang‐Chuan , Zhong Mei‐Jin , Liang Yong‐Min
Published: August 2012

A new, mild, and efficient domino synthesis of the title compounds is developed.
ChemInform Abstract: Light‐Induced Carbocyclization of Iodoalkenes.
Authors: Campos‐Gomez Esther , Campos Pedro J. , Gonzalez Hector F. , Rodriguez Miguel A.
Published: August 2012

The direct irradiation of iodoalkenes leads to homolysis of the C—I bond followed by cyclization with formation of 6‐membered.
ChemInform Abstract: Organocatalytic Stereocontrolled Synthesis of 3,3′‐Pyrrolidinyl Spirooxindoles by [3 + 2] Annulation of Isocyanoesters with Methyleneindolinones.
Authors: Wang Liang‐Liang , Bai Jian‐Fei , Peng Lin , Qi Liang‐Wen , Jia Li‐Na , Guo Yun‐Long , Luo Xi‐Ya , Xu Xiao‐Ying , Wang Li‐Xin
Published: August 2012

The annulation proceeds with anti‐ or syn‐stereoselectivity depending on the N‐protecting group of starting oxindoles.
ChemInform Abstract: Passerini Reactions for the Efficient Synthesis of 3,3‐Disubstituted Oxetanes.
Authors: Beasley Banjamin O. , Clarkson Guy J. , Shipman Michael
Published: August 2012

The reaction of unsubstituted oxetan‐3‐one (I) with isocyanides and carboxylic acids allows the access to various pharmaceutically interesting products of type (IV).
ChemInform Abstract: Formal [4 + 1] Annulation of Cyclopropyl Amides and Water Mediated by Lewis Acid: A Novel Entry to γ‐Butyrolactones.
Authors: Zhang Dingyuan , Zhang Rui , Liang Yongju , Dong Dewen
Published: August 2012

A ring‐opening/recyclization process of readily available cyclopropylamides (I) is efficiently achieved with the Lewis acid SnCl4 to offer a novel synthesis of γ‐butyrolactones (II).
ChemInform Abstract: Ruthenium‐Catalyzed Transfer Oxygenative Cyclization of α,ω‐Diynes: Unprecedented [2 + 2 + 1] Route to Bicyclic Furans via Ruthenacyclopentatriene.
Authors: Yamashita Ken , Yamamoto Yoshihiko , Nishiyama Hisao
Published: August 2012

Generally, a broad spectrum of bicyclic furan skeletons can be obtained from diynes bearing 2 terminal aryl substituents under the optimized conditions A)‐C).
ChemInform Abstract: Catalytic Enantioselective Construction of Quaternary Stereocenters by Direct Vinylogous Michael Addition of Deconjugated Butenolides to Nitroolefins.
Authors: Manna Madhu Sudan , Kumar Vikas , Mukherjee Santanu
Published: August 2012

The title reaction provides access to highly functionalized γ‐butenolides bearing contiguous quaternary and tertiary stereocenters with high to excellent diastereo‐ and enantioselectivities.
ChemInform Abstract: Regiospecific Synthesis of Cepanolide, a Cancer Chemoprotective Micronutrient Found in Green Onions.
Authors: Boukouvalas John , Albert Vincent
Published: August 2012

On treatment with thiols, the brominated hydroxybutenolide (II) can be regioselectively converted to cepanolide (IVa) and some analogues.
ChemInform Abstract: New Fluoride‐Promoted Hypoiodite‐Catalytic Oxidative Cycloetherification to Aromatic Spiroketals.
Authors: Wei Wei , Li Liqi , Lin Xiaohong , Li Haifeng , Xue Jijun , Li Ying
Published: August 2012

Hypoiodide reagents, generated in situ from Bu4NI, catalyze the synthesis of bisbenzannulated spiroketal cores.
ChemInform Abstract: CN‐Assisted Oxidative Cyclization of Cyano Cinnamates and Styrene Derivatives: A Facile Entry to 3‐Substituted Chiral Phthalides.
Authors: Reddy R. Santhosh , Kiran I. N. Chaithanya , Sudalai Arumugam
Published: August 2012

A novel, highly practical, and efficient approach to the title compounds is developed.
ChemInform Abstract: Palladium‐Based Catalytic System for the Direct C3‐Arylation of Furan‐2‐carboxamides and Thiophene‐2‐carboxamides.
Authors: Si Larbi Karima , Fu Hai Yan , Laidaoui Nouria , Beydoun Kassem , Miloudi Abdellah , El Abed Douniazad , Djabbar Safia , Doucet Henri
Published: August 2012

The Pd‐catalyzed direct arylation of title furan‐ and thiophenecarboxamides proceeds regioselectively at position C‐3 when the system Cs2CO3—xylene is applied.