bluuebunny/crossref_metadata_2025 huggingface dataset:
Toxicity and antioxidant activity of 4-hydrazinoquinoline derivatives
Authors: Romanenko Y. , Kozyr A.
Published: January 2023

Annotation. 4-hydrazinoquinoline derivatives have a wide pharmacological potential. The study of their biological properties showed that they have not only antimalarial, antituberculosis, antiviral activity, but also are good antioxidants. First of all, the toxicity of investigated compounds has been evaluated in silico and in vivo. Software solutions were used for building “structure-toxicity” models and predicting LD50 with the help of GUSAR (Germany), TEST (USA) models. Experimental studies were carried out on 64 white mice without a breed of both sexes weighing 16-24 g. Derivatives of 4-hydrazinoquinoline are classified as low and moderately toxic compounds. Antioxidant activity was investigated on 10 4-substituted quinoline compounds and compared with reference drugs. For the research we used the native material – ejaculates of fertile men (normozoospermia). For this purpose, the indicators of the standard spermogram were previously evaluated according to generally accepted methods in accordance with WHO criteria. Oxidative stress (OS) was created in cells with the help of 3% hydrogen peroxide. To protect against OS caused by hydrogen peroxide, the studied compounds and comparative drugs with AO properties (AK and ACC) were used. The obtained results were processed using the program “STATISTICA® for Windows 6.0” (StatSoft Inc, No. АХХР712D833214FAN5) by methods of variational statistics using the Student’s t-test. Investigating the average speed of motile spermatozoa, it was found that compounds with residues of acetic and pentanedioic acids exceeded the comparison drugs. (Е)-2-(2-(7-chloroquinolin-4-yl)hydrazono)acetic acid demonstrated a stronger effect on 8-10 % than the comparative drug ACC. Disodium (Е)-2-(2-(2-methylquinolin-4-yl)hydrazono)pentanedioate has an advantage over the level of action of AA by 15%. Derivatives of (2-(quinolin-4-yl))hydrazono)carboxylic acids in the conditions of H2O2-induced OS were generally inferior to comparison drugs AA and ACC. These results demonstrate that derivatives of (2-(quinolin-4-yl))hydrazono)carboxylic acids exhibit favorable antioxidant properties and are promising protectors of spermatozoa in OS conditions. The studied series of quinoline derivatives requires both further in-depth studies of the mechanisms of AO protection and favorable structural modifications in this series.
Peculiarities of relationships between rheoencephalographic and anthropo-metric indicators of mesomorphic volleyball players somatotype
Authors: Sarafyniuk L. A. , Merkulova D. O.
Published: January 2023

Annotation. For early detection of signs of fatigue and overtraining at high altitude of professional sportsmen, quality is of great practical importance monitoring of the state of the cardiovascular system, in particular indicators of cerebral hemodynamics in combination with individual constitutional features of the body. The purpose of the study was determination of features of relationships between rheoencephalographic indicators and parameters of the external body structure of volleyball players youth of a high level of skill, which belonged to the mesomorphic constitutional type. They conducted a comprehensive study of 70 young men (aged from 17 to 21 years old), who played volleyball for at least 3 years and achieved a high level skill level (small sports categories from the first adult to masters of sports). After somatotyping according to the Heath-Carter (1990) found mesomorphic somatotype in 36 volleyball players. Rheoencephalography was performed on a computer diagnostic complex according to by the method of Ronkin and Ivanov (1997), anthropometry - by the method of V. V. Bunak (1941), correlation analysis - according to Spearman's method. It was established that in cerebral indicators of mesomorphic somatotype volleyball players hemodynamics had individual anthropo-somatotypological parameters reliable relationships, most of which were directly proportional to mean strength. Temporal correlations had the greatest strength and number of statistically significant correlations rheoencephalographic indicators, in particular the time of the ascending part rheoencephalograms. Most often with indicators of cerebral hemodynamics total body dimensions (length and surface area) were reliably correlated bodies, height of anthropometric points, anterior-posterior and transverse diameters body, girth measurements of chest and limb segments, separate craniometric dimensions). The study of correlations is the basis determining the harmony of physical development of athletes and further mathematical modeling to determine individual dues rheoencephalographic indicators.
Glomus Venous malformation of the skin of the left ankle-foot joint: a clinical case and review of the literature
Authors: Vernygorodskyi S. V. , Kostiuk O. G. , Kostiukov A. O.
Published: January 2023

Annotation. The work presents a clinical and histological description of a case of glomuvenous malformation and a review of modern data on the diagnosis and treatment of this disease. A case of diagnosis of glomuvenous malformation on the foot of the right lower limb in a 46-year-old man was analysed. The case was characterized by an uncertain dermatological status with the need to exclude malignant neoplasia of the skin. Considering doubts about the benign nature of the skin lesion, the patient was recommended to undergo a therapeutic and diagnostic biopsy. After a medical-diagnostic biopsy, histological sections showed skin with moderate hyperparakeratosis of the epidermis and a clearly delineated, non-encapsulated formation in the dermis. The tumour is represented by numerous vascular channels of the venous type of small and medium caliber, some of which have an enlarged lumen and a thickened wall, filled with erythrocytes. Clusters, chains, and fields of monomorphic glomus cells with weakly expressed eosinophilic cytoplasm and rounded nuclei with finely dispersed chromatin are located perivascularly, without atypia. Mitotic figures are absent. The intercellular stroma is sclerosed with focal oedema. Considering the results obtained by us and the data of modern studies, we can state the ambiguity of views on the diagnosis of glomuvenous malformation with the need for more aggressive diagnostic and therapeutic tactics in adults. The development of an algorithm for the management of adult patients with glomuvenous malformation of the skin is a prospect for further research.
Variability of the level of the N-terminal fragment of brain natriuretic propeptide in plasma in hypertensive patients with/and without chronic coronary disease
Authors: Ivanov V. P. , Zakrevska M. M.
Published: January 2023

Annotation. The article presents the results of studying the variability of the level of the N-terminal fragment of brain natriuretic propeptide (NT-proBNP) in plasma in patients with hypertension with/and without chronic coronary disease. An open observational one-point randomized comparative study included 118 patients with stage II hypertension with/and without chronic coronary disease (stable angina pectoris I-III functional class). An additional criterion for inclusion in the main group was the presence of atrial fibrillation. All patients, in addition to general clinical examination, additionally determined the levels of NT-proBNP in the blood plasma. Statistical processing of the obtained data was carried out using Microsoft Excel (2016) and Statistica 12.0 (Statsoft, USA). Absolute values were presented as the average value of the indicator (Mean) ± standard deviation for the sample (SD, standard deviation). Comparison of mean values in groups was performed using one-way ANOVA & LSD test. The dependence of the NT-proBNP level on the duration of the hypertensive history, the value of the functional classes of angina pectoris of chronic heart failure was proven. At the same time, it was demonstrated the lack of interdependence of the level of this biomarker with the clinical variant of atrial fibrillation and its characteristics, such as the duration of the history, ENRA class and frequency of attacks. The fact of a decrease in the level of NT-proBNP in the plasma in the case of alimentary-constitutional obesity and an increase in the body mass index was confirmed. In addition, an increase in the level of this biomarker was observed in the case of presence of hypertrophy of the left ventricle according to the ECG data, as well as in the case of a decrease in the value of the glomerular filtration rate, calculated according to the CKD-EPI formula.
The influence of bacterial translocation and systemic inflammation on the nutrition, skeletal muscles, and survival of patients with liver cirrhosis
Authors: Motsiuk V. M. , Pentiuk N. O.
Published: January 2023

Annotation. Malnutrition and sarcopenia are common prognosis-modifying complications of liver cirrhosis (LC). Bacterial translocation and systemic inflammation may be involved in the development of nutritional and muscle insufficiency in LC. The aim of the study was to assess the relationship between serum markers of bacterial translocation and systemic inflammation with nutrition, skeletal muscle, and survival in patients with decompensated LC. 74 patients (age 55.3±11.4 years) were included in the study. Nutritional status was assessed using the Patient-Generated Subjective Global Assessment (PG-SGA). Skeletal muscle mass was assessed using the Skeletal Muscle Index (SMI), and muscle strength was assessed by handgrip strength. The level of lipopolysaccharide-binding protein (LBP), interleukin-6 (Interleukin-6, IL-6), and C-reactive protein (C Reactive Protein, CRP) in blood serum was determined by enzyme immunoassay (ELISA). Statistical data processing was performed in SPSS22. It was found that serum LBP, IL-6, and CRP levels moderately correlated with PG-SGA (r= 0.549, 0.434, and 0.453, respectively, p˂0.005), SMI (r= -0.517, -0.518, and -0.468, respectively, p˂0.005), and handgrip strength (r= -0.338, -0.427, and -0.423, respectively, p˂0.005), and predicted severe malnutrition (AUC (LBP) = 0.746; AUC (IL-6) = 0.672; AUC (CRP) = 0.745, p˂0.05) and sarcopenia (AUC (LBP) = 0.861; AUC (IL-6) = 0.789; AUC (CRP) = 0.744, p˂0.01). 42 patients died from LC complications during the follow-up (Me 367 (82-569) days). In the Kaplan-Meier analysis, the mortality of patients with high levels of LBP (more than 33.4 pg/ml), IL-6 (more than 7.68 pg/ml), and CRP (more than 5.52 mg/l) were significantly higher than that of patients with conditionally low levels. Further studies are needed to determine whether correction of bacterial translocation and systemic inflammation can improve nutritional, skeletal muscle status, and survival in patients with decompensated LC.
Findings on chin development and anatomy: a review of the literature
Authors: Kulytska O. V. , Shuvalov S. M. , Shkilniak L. I. , Lonskyy K. L.
Published: January 2023

Annotation. The anatomy of the chin is of increasing interest in the community of maxillofacial surgeons. Features of development, bone structure, blood supply and innervation of the chin region are studied, as a rule, independently of each other and require generalization of knowledge. The purpose of the study was to collect data on the chin area, compare and summarize them; identify aspects of chin anatomy and development that require further study. Articles published in the 2000-2021 scientometric databases Pubmed and Medline were selected for analysis. Articles related to the development, blood supply, innervation and structure of the chin bone were considered. The main conclusions from the identified sources related to the following. The chin is a specific and new formation of a modern person, which has peculiarities of development, bone structure, blood supply and innervation. The reviewed articles contained scattered data and often revealed only one aspect of chin morphology. Some of them are related to ontogeny, others describe isolated facts about blood supply or bone structure without showing the relationship between development and morphology. Many studies have been conducted to identify the influence of the features of the chin structure on orthodontic treatment, installation of implants, and only a few of them are devoted to the healing of this area after trauma or the features of the development of various diseases. Since the chin area is a specific and new formation compared to other parts of the lower jaw, studies of various bone pathology in this area are necessary. Many publications are devoted to the study of the blood supply of the chin area, feeding holes and channels on the lingual surface of the lower jaw, and these data are widely used in surgical practice. The innervation of the chin, the influence of structural features on the healing of fractures and grafts, the difference in the healing of the bones of individual areas of the lower jaw are usually not described and require in-depth study.
Evolution of prostatic lodge hemostasis methods during transbladder prostatectomy in patients with benign hyperplasia of prostate (literature review)
Authors: Gorovyi V. I. , Shaprynskyi V. O. , Kapshuk O. M. , Moraru-Burlesku R. P. , Dovgan I. I. , Malasaev M. O. , Balatskyi O. R. , Taheiev V. R.
Published: January 2023

Annotation. The article presents a review of the literature on the evolution of hemostasis methods during open transbladder prostatectomy in patients with benign hyperplasia. The improvement of methods of hemostasis during transbladder prostatectomy has gone from suturing the prostate lodge, suturing the bladder neck and prostate capsule to partial suturing of the prostate lodge with the installation of a Foley catheter for the purpose of mechanical compression of the bladder neck and prostate lodge. The methods of hemostasis of Ukrainian urologists, including those of Vinnytsia, are highlighted. Unfortunately, none of the methods guaranteed 100% hemostasis of the prostate lodge after prostatectomy. Therefore, the search for new and improvement of known methods of hemostasis of the prostate lodge is an urgent issue in urology.
Postnatal neurogenesis in the neuroproliferative areas of the brain
Authors: Khodak T. V. , Tykholaz V. O. , Shevchenko V. M.
Published: January 2023

Annotation. The purpose of the work is to systematize and analyze existing problematic aspects in the study of postnatal neurogenesis in neuroproliferative areas of the brain. The relevance of this problem is due to the growing share of neurodegenerative diseases and the search for the possibility of their treatment. From the databases PubMed, ScienceDirect, UpToDate, Web of science, Scopus, 28 sources on this problem were selected for consideration, regardless of age, with a predominance of publications from the last 10 years. The state of research related to the study of postnatal neurogenesis in the neuroproliferative areas of the brain (hippocampus) is highlighted as a result of the scientific and theoretical analysis of literature sources. Further branches of research are outlined. The lack of clear data on the structure of different areas of the hippocampus under the action of neurogenesis-inhibiting factors with subsequent stimulation in these same areas was revealed. The need for standardization of immunohistochemical methods of research and improvement of the method of detection of known neurospecific proteins, which are markers of proliferation or apoptosis, has been identified, which will enable both the comparison of the results obtained by different researchers and their interpretation.
Application of climatological approach to determine the temperature of radiation fogs formation
Authors: Hrushevskyi O. M. , Yatsyshen A. O.
Published: January 2023

The effectiveness of a radiation fog forecast is determined by the accuracy of a forecast for two values – temperature of fog formation and minimum air temperature. The accuracy of the first measurement significantly depends on a degree of adaptability of a forecast method to specific factors affecting the formation of fogs – orthography, local circulations, seasons, time of day, temperature-humidity stratification in the boundary layer of the atmosphere, etc. Taking into account each of them in a specific point will dictate its characteristics, whereas use of non-adapted fog forecasting methods will reduce their effectiveness.

The article suggests an approach that makes it possible to carry out a comparative analysis of the prognostic value of the fog formation temperature and its average value pertaining to a specific point, season and time of day.

In order to implement the studied approach the research considered a daily-annual repeatability of fogs at Kyiv station over 2012-2020. Based on this an average temperature of fog formation for each combination of month and time of day was determined according to actual observation data and, for the purpose of comparison, according to the Sanders method that uses data from radio sounding of the atmosphere as its baseline. The results of the analysis of the structure of the fog repeatability distribution allowed approximation of the daily-annual distribution of fog formation temperature via polynomial functions and a harmonic two-dimensional oscillator. Based on the selected efficiency criterion it was determined, via sequential selection, that the polynomial approximation of the data indicating the actual temperature of fog formation during the year is the most effective method. Obtaining an analytical form of the probability distribution function of daily and annual values of the fog formation temperature allows us to plot graphs of its daily variability for any month of the year. Such result makes it possible to control emissions of forecast values of fog formation temperature for a specific point, season and time of day, which will increase the effectiveness of the existing ways of making the forecasts in question.
Prospects for green infrastructure development to improve the living comfort for the population of Odesa
Authors: Husieva K. D. , Safranov T. A.
Published: January 2023

The paper is aimed at identification of the prospects for development of green infrastructure as an element of the comfort of living for the urban population of Odesa.

The authors briefly described the natural and climatic characteristics of the city. An overview of the research into the development of green infrastructure in urban areas and its connection with the comfort of living for the population in the latest papers of Ukrainian and foreign scientists, such as Bonetskyi, Carter, Cuthbert, Fisher, Henriquez, Huang, Liu, Martins, Nazaruk, Newell, Ocheretnyi, Pryshchepa, Rendekova, Rahman, Sakieh, Sholok, Vasylieva, Zheng, Zibtseva, etc., was performed.

The percentage of the city's green space area per resident was calculated and compared to the normative value, a map of the provision of Odesa residents with green spaces was given, and the city districts with maximum and minimum green areas were identified.

The paper characterized the species composition of the city’s flora, including the species of native woody, shrubby and herbaceous plants and those imported from other countries and continents.

During identification of promising ways to develop green infrastructure within the territory of Odesa, the authors found that for improvement of the comfort of living in the city it is necessary to increase the share of green infrastructure, in particular, to form the green belt of Odesa and create green roofs and walls.

The authors gave recommendations for the future expansion of the existing project on formation of the green belt of Odesa, which provides for a system of ecological corridors around the historical centre of the city, to all city districts and the outskirts.

The main functions and advantages of green roofs and walls are indicated in terms of improvement of the quality of life of the urban population. In view of rather rapid climate change, when creating new green areas, the authors recommended to give attention to drought-resistant bushy trees, shrubs and perennial tall grasses, primarily of local origin.

The paper also mentions the main possible directions of further research regarding identification of the optimal set of plantations and efficient approaches to the introduction of green infrastructure elements.
Public monitoring as a tool for assessing the state of the air basin in the Ukrainian Regions
Authors: Chugai A. V. , Lavrov T. V.
Published: January 2023

Over the recent years automated observation systems that work continuously and allow obtaining information at any time have been widely implemented. Such systems include public monitoring systems in order to receive more complete information about the quality characteristics of the air basin over Ukraine. Examples of public monitoring organizations include SaveEcoBot, EcoCity, SaveDnipro.

The information presented on the websites of the public monitoring system contains large amount of data that are difficult to process and analyze. In order to optimize data processing, a program called PublicMonitoringParser was developed. It transforms large volumes of data presented on the Internet resource SaveEcoBot.com into compact, convenient, small files containing average monthly concentrations of pollutants and indicators of meteorological parameters. The program is written using the C# programming language and the .NET platform. The structure of the program and the principles of its operation are presented in this research.

According to the data of the website SavEecoBot.com the developed program was applied for assessment of the air basin state of Lviv Region in 2021. In general, for most substances, monitoring data were available only at the station in the city of Lviv at the following address: 13 Plastova Str. Monitoring of PM2.5 and PM10 content was carried out across the whole region.

It was detected that the content of NO2, SO2, NH3 exceeded the limit value. Significant excesses were also noted for the NH3 content (up to 9 – 16 MPC). It was established that the location of the public monitoring station was surrounded by industrial buildings, numerous transport industry enterprises, an oil depot for OKKO gas stations and city sewage treatment facilities. A comparison of the data obtained at stationary and automated points that monitor individual pollutants showed that the results are comparable only for the NO2 content.

Data from automated observation points complement the network of stationary points. Currently, the existing stationary network of atmospheric pollution monitoring across most regions of Ukraine is outdated and needs to be re-equipped. In general, it is necessary to further implement automated systems that are able to characterize the state of the air basin across individual populated places in a more complete and detailed manner.
ANALISIS USABILITY UNTUK PENGGUNAAN APLIKASI SIGNATURE QR CODE PADA KEABSAHAN DOKUMEN SKRIPSI TERHADAP KEPUASAN PENGGUNA MENGGUNAKAN USE (Usefulness, Satisfaction, Ease Of Use) QUESTIONNAIRE.
Authors: Syah Nur Alam , Muflih M. , Rosadi Muhammad Edya , Muharir Muharir
Published: January 2023

Sejak Awal 2020 Penyebaran Coronavirus (Covid-19) begitu cepat bahkan telah menjadi pandemi secara global yang mempengaruhi negara-negara berkembang dengan sumber daya terbatas (Mishal et al., 2020). Pandemi Covid-19 membuat beberapa perusahaan hingga pendidikan tinggi terkena dampak dalam segi sektor, aktivitas sosial, hingga manajemen(Riza, 2020). Pandemi ini memberikan dampak yang cukup besar juga bagi siklus dunia pendidikan tinggi dari segi kinerja staff (Sudaryono et al., 2020).Pemerintah sudah mengeluarkan Instruksi Menteri Dalam Negeri No. 22 Tahun 2021 Tentang Pemberlakuan Pembatasan Kegiatan Masyarakat Level 4 Covid-19  di Wilayah Jawa dan Bali untuk mengatasi penyebaran Covid-19 dimana sesuai dengan instruksi ini pelaksanaan kegiatan masih dilaksanakan secara daring/online. Akibat dari pembatasan kegiatan masyarakat, ICT for Development Researcher Daniel Oscar Baskoro mengatakan semakin banyak yang memanfaatkan fasilitas digital yang ada, dan orang-orang bisa melakukan pekerjaan dari jarah jauh. Menurut Kominfo salah satu adopsi teknologi yang paling masif yaitu tanda tangan digital atau digital signature, tercatat penggunaan tanda tangan digital melonjak 350 persen selama pandemi. Bagi mahasiswa yang sedang atau telah mengerjakan penelitian atau skripsi khususnya untuk dokumen-dokumen yang harus ditanda tangani. misalkan sedang butuh tanda tangan dosen pembimbing untuk lembar pengesahan skripsi atau tanda tangan lembar penguji, dengan dibatasi kegiatan dikampus dimasa pandemi atau kebetulan dosen pembimbing atau penguji diluar kota maka solusinya adalah tanda tangan dalam bentuk digital atau Signature QR Code.
KLASIFIKASI TINGKAT KOMPETENSI MAHASISWA UNISKA MENGGUNAKAN KOMBINASI ALGORITMA K-NEAREST NEIGHBORS (KNN) DAN MANHATTAN DISTANCE
Authors: Andie Andie , Hasanuddin Hasanuddin
Published: January 2023

Kompetensi adalah kemampuan kerja setiap individu yang mencakup aspek pengetahuan, keterampilan, dan sikap kerja yang sesuai dengan standardisasi yang diharapkan. Pada dunia kerja, kompetensi dibutuhkan untuk mengetahui tipe pekerjaan seperti apa yang tepat bagi seseorang. Apabila kompetensi atas diri seorang karyawan telah diketahui maka perusahaan pun mampu membantu untuk mengembangkan pribadi melalui training atau pelatihan tertentu. Dataset pada penelitian ini diambil dari mahasiswa uniska yang akan mempersiapkan diri ke dunia kerja . Salah satu cara untuk mengklasifikasi tingkat kompetesi mahasiswa dalam machine learning yaitu menggunakan dataset sebagai data latih agar dapat dilakukan pengujian performa dengan metode klasifikasi yang tepat. Metode yang digunakan dalam penelitian ini yaitu algoritma K-Nearest Neighbor (KNN), dimana merupakan sebuah metode untuk melakukan klasifikasi terhadap objek berdasarkan data pembelajaran yang jaraknya paling dekat dengan objek tersebut. Dari hasil pengujian yang telah dilakuan dapat disimpulkan bahwa penerapan metode K-NN dengan Manhattan Distance diperoleh hasil akurasi tertinggi dengan nilai sebesar 94%, dengan k=5. Persentase tersebut menunjukkan bahwa Manhattan Distance bekerja dengan baik dalam memberikan rekomendasi untuk klasifikasi kompetensi mahasiswa.
ANALISIS KLASIFIKASI DATASET INDEKS STANDAR PENCEMARAN UDARA (ISPU) DI MASA PANDEMI MENGGUNAKAN ALGORITMA SUPPORT VECTOR MACHINE (SVM)
Authors: Ridho Ihda Innar , Mahalisa Galih
Published: January 2023

Kualitas udara atau air quality merupakan kadar kandungan udara berdasarkan konsentrasi polutan di lokasi tertentu. Pada masa Pendemi terdapat adanya perubahan kualitas udara yang terjadi di indonesia. Penelitian ini akan melakukakn analisis klasifikasi tingkat kualitas udara berdasarkan dataset ISPU. Data mining dikelompokkan dalam dua kategori, yakni supervised dan unsupervised. Algoritma Support Vector Machine (SVM) adalah suatu metode yang menggunakan algoritma supervised, SVM digunakan untuk mencari hyperplane terbaik dengan memaksimalkan jarak antar kelas. Hyperplane adalah sebuah fungsi yang dapat digunakan untuk pemisah antar kelas. Metode yang digunakan dalam penelitian ini yaitu algoritma Support Vector Machine (SVM), dimana merupakan sebuah metode untuk melakukan klasifikasi terhadap objek berdasarkan data pembelajaran yang jaraknya paling dekat dengan objek tersebut. didapatkan hasil pengujian tertinggi dengan menggunakan support vector dengan nilai accuracy sebesar dengan akurasi 97%. Hal ini membuktikan bahwa pada masa pandemi covid-19 kualitas udara menjadi lebih sehat atau dalam kondisi sedang.
PROTOTYPE SISTEM PROMOSI DAN PENYEWAAN GEDUNG BERBASIS DIGITAL , STUDY KASUS : GEDUNG TAMAN BUDAYA BANJARMASIN
Authors: Rusdina Rusdina , Rasyidan Muhammad , Rusdi Muhammad
Published: January 2023

Di kota Banjarmasin Kalimantan Selatan, Gedung Taman Budaya adalah salah satu gedung yang biasa digunakan untuk acara pernikahan, adat dan acara sejenisnya. Pengelolaan penyewaan Gedung ini masih menggunakan buku besar dalam  proses  pencatatan  data, Walaupun  data  yang  telah  tersimpan  didalam  buku  besar  dirasa  sudah cukup  , tetapi  pada  saat  proses pengelolaan data pemesanan dan pencarian jadwal ketersediaan gedung selalu mengalami kendala dalam pencarian data sehingga kurang efisien. Penyimpanan data juga tidak  aman karena resiko kemungkinan  data  hilang  sangat  besar. Masalah  yang  dihadapi lainnya  adalah  calon  penyewa harus  datang  langsung  ke kantor  pemesanan  atau  sekedar  menelepon untuk mencari informasi dan mengecek ketersediaan gedung sesuai hari yang diinginkan, dikarenakan permasalahan itu, diberikan solusi sebuah Sistem Otomatisasi penyewaan gedung yang dapat membantu proses  Promosi Dan Penyewaan Gedung Berbasis Digital kemudian di Implementasi kan ke  Objek Penelitian berbasis Web dengan bahasa pemograman PHP, untuk pengecekan ketersediaan gedung, penyimpanan data pemesanan, dan  perekapan   data   pemesanan agar alur untuk Promosi Dan Penyewaan Gedung dapat dengan mudah diakses oleh calon penyewa dan tidak perlu membuang waktu untuk mendatangi lokasi.
Konsep Three-Pass Protocol Pengamanan Teks Menggunakan Metode Playfair Cipher Dengan Gronsfeld Cipher
Authors: Ridho Abdurrahman , Mutia Cut , Putri Andriani
Published: January 2023

Keamanan komputer khususnya data merupakan hal yang tidak dapat terpisahkan dari penggunaan komputer sehari-hari baik itu menggunakan gawai seperti telepon seluler maupun komputer/laptop. Aktifitas enkripsi dapat kita jumpai saat ini pada aplikasi pesan instan seperti whatsapp untuk melindungi privasi penggunanya yang menjamin bahwa pesan teks tersebut aman dari gangguan entitas yang tidak berkepentingan, pengembangan metode-metode enkripsi baik itu memunculkan metode baru maupun mengkombinasikan metode yang sudah ada akan terus dilakukan demi tercapainya perlindungan data yang baik. Konsep Three-pass protocol hadir untuk menghindari adanya pertukaran kunci antara pengirim dan penerima yang dapat menjadi masalah ketika di transmisikan, namun Three-pass protocol tidak dapat diimplementasikan kepada semua cipher.
PEMANFAATAN SMART VILLAGE DALAM UPAYA PENINGKATAN PELAYANAN KEPADA MASYARAKAT PADA DESA PONCOWARNO
Authors: Wati Rina , Yono Suyono
Published: January 2023

Smart Village merupakan penggunaan teknologi informasi dan komunikasi untuk meningkatkan kenyamanan, keamanan, efisiensi dan kemampuan kerja dalam memberikan pelayanan yang berkelanjutan serta dapat meningkatkan kehidupan masyarakat desa khususnya pada aspek tata kelola, tata niaga dan tata sosial desa.Penerapan smart village saat ini sudah mulai diterapkan di desa desa, salah satunya adalah Desa Poncowarno yang berlokasi di kecamatan Kalirejo Kabupaten Lampung Tengah dengan jumlah kepala keluarga 1269 dengan total jumlah penduduk 7089 jiwa sudah menerapkan smart village sejak awal tahun 2021,berdasarkan fakta bahwa pelayanan konvensional oleh pemerintahan desa dinilai masyarakat masih belum optimal,  permasalahan pengolahan data secara manual masih memiliki banyak kekurangan, permasalahan yang sering dikeluhkan masyarakat seperti lambatnya pelayanan,pemberkasan data yang membutuhkan waktu lama, alur admistrasi yang panjang hingga arsip yang hilang,dari permasalahan ini lah keberadaan Smart Village dinilai dapat dimanfaatkan untuk melakukan pendataan desa yang lebih baik dan sebagai media pelayanan informasi kepada masyarakat.Hasil dari penelitian peningkatan teknologi informasi ini menunjukan keberhasilan dengan indikasi kepuasan dan kemudahan bagi masyarakat sehingga mampu memberikan wadah dikarenakan pelayanan bisa dilakukan secara online.
Batık Maliyetler, İhracat ve Reel Kur İlişkisi
Authors: ATABEK DEMİRHAN Aslıhan , AKDOĞAN Kurmaş
Published: January 2023

İhracata girmeyi planlayan firmaların karşılaşacağı maliyetlerin birçoğu ihracattan vazgeçildiği zaman geri dönüşü olmayan harcamalardan yani batık maliyetlerden oluşmaktadır. Batık maliyetlerin varlığı, firmaların ihracat pazarına girme veya ihracat pazarından çıkma kararlarını gecikmeli olarak almalarına yol açabilmektedir. Firma düzeyinde gözlenen bu atalet aynı zamanda makro düzeyde reel kur-ihracat ilişkisinde bozulmalara da neden olabilmektedir. Bu çalışmada öncelikle firma düzeyinde veriler çerçevesinde imalat sanayi firmalarının ihracat kararlarında atalet etkisi incelenmiştir. Tahmin sonuçları firmaların batık maliyetlere maruz kaldıklarını göstermiştir. Batık maliyetlerin neden olduğu ataletin sektör düzeyinde reel kur-ihracat ilişkisine olası etkilerini incelemek amacıyla Preisach yaklaşımı kullanılarak ihracattaki kalıcılık analizinde kur seviyesinin etkisi incelenmiştir. Sonuçlar, ihracata girişte batık maliyetlerin neden olduğu gecikmenin, tekstil, hazır giyim, tütün, makine-teçhizat ve iletişim araçları alt sektörleri haricinde kalan sektörlerde ihracatın reel kur değişimlerine duyarlılığını sınırladığına işaret etmektedir.
Gelişmiş ve Gelişmekte Olan Borsalar ile Kripto Varlık Piyasasında Fraktal Piyasa Hipotezinin Testi
Authors: SAĞLAM BEZGİN Müge
Published: January 2023

Bu çalışmada, piyasa istikrarı ve yatırımcı ufkunu açıklayan, finansal zaman serilerinin normal dağılmadığını ve finansal zaman serilerinde kendine benzerlik özelliği olduğunu ifade eden fraktal piyasa hipotezinin iki gelişmekte olan, iki gelişmiş piyasada ve iki kripto varlıkta geçerliliğinin Hurst Üsteli- Yeniden ölçeklendirilmiş aralık (R/S) Analizi yöntemi aracılığıyla araştırılması amaçlanmıştır. MSCI sınıflamasına göre gelişmiş piyasalar olarak SP500 ve FTSE, gelişmekte olan piyasalar olarak Borsa İstanbul 100 ve Shanghai Endeksi incelemeye dahil edilmiştir. Kripto varlıklarda ise işlem hacmi en yüksek olan Bitcoin ve Ethereum değişkenleri incelemeye dahil edilmiştir. Çalışma bulgularına göre incelenen tüm endekslerde fraktal piyasa hipotezinin varlığı kabul edilirken, uzun hafızanın rolü ise değişmektedir. Tüm değişkenlerde Hurst üsteli değeri 0.5 değerinden yüksektir. Hurst üsteli sonuçlarına göre tüm değişkenlerde zaman serisinin kalıcı davranış gösterdiğine ilişkin hipotez kabul edilmiştir. Uzun hafızanın kalıcılığın en düşük olduğu değişken FTSE’dir. Gelişmekte olan borsalarda uzun hafıza ve kalıcılık gelişmiş borsalara göre daha yüksekken tüm değişkenler içerisinde uzun hafızanın en güçlü olduğu ve kalıcılığın en yüksek olduğu değişken ise Bitcoin’dir.
İŞLETMELERDE FİNANSAL RİSK YÖNETİMİ VE FİNANSAL ANALİZ: BİST’E İŞLEM GÖREN ENERJİ ŞİRKETLERİ ÜZERİNE BİR UYGULAMA
Authors: ADIGÜZEL İdris
Published: January 2023

Finansal risk yönetimi, tüm işletmeler için büyük önem taşımaktadır. Çünkü finansal riskler tüm ekonomik sistemleri etkiler. İşletmeler etkin finansal risk yöntemleri sayesinde maruz kalabilecekleri zararların altındaki etkenlerin azalmasını sağlarken, diğer yandan da zayıf noktaları güçlendirerek kar oranlarının artmasını sağlamaktadır. Bu makale çalışmasında enerji sektöründe yer alan beş firmanın mali yapı rasyo analiz teknikleriyle karşılaştırmalı olarak incelenmiştir. Bu incelemeyle ulaşılmak istenilen, firmanın başarısızlıktaki etkenleri risk yönetimi ve analiz teknikleriyle ortaya koymak ve diğer başarılı firmalar ile mukayese yapmaktır. Yapılan incelemeler sonucunda başarısız bir firmanın ana faaliyetleri konusunda başarısız olması, firmanın karlılığını ve verimliliğini azaldığını gösterir. Başarısız firmanın gerek finansal risk yönetimi gerekse mali analiz yöntemlerini etkin ve verimli bir şekilde kullanmadığı görülmüştür.
Ramachandran Chart
Authors: Linhares Micaely , Kelry Costa Guimarães Dyuly , Santos Kethelin Vitória Zaire dos , Barros Henrique Lopes de , Miranda Marcio Rodrigues , Silva Kaio Alexandre da
Published: January 2023

A few years ago, validating proteins to see if they were good or bad was a process that took years. With the creation of the Ramachandran Graph that evaluates protein structures through the angles φ (phi) and ψ (psi), this task became less onerous. With the evolution of computing and bioinformatics, platforms have been created to generate Ramachandran graphs in an online manner, however, the platforms have a high degree of usability complexity. The system proposed by this project puts the user as the center of the development, developing a system that can generate the Ramachandran graphs from the files sent, make the outlier analysis and return to the user through e-mail communication when the activities are finished.
Analysis of the correlation between Guillain-Barré and post-COVID-19 syndromes
Authors: Lopes Martins Matheus , Carvalho Melo Sabrina , De Brito Silva Amanda , Miranda de Souza Luan Kelves
Published: January 2023

OBJECTIVE: To correlate Guillain-Barré as a consequence of the Post-COVID-19 syndrome, evaluating the pathophysiological, immunogenic and epidemiological mechanisms. METHODOLOGY: A systematic review was carried out, with secondary data, using articles published in the following databases: Latin American Caribbean Literature on Science and Health (LILACS), Scientific Electronic Library (ScIELO) and Pubmed; using the descriptors: Guillain-Barré syndrome; Demyelinating Diseases and COVID-19, using the Boolean operator “AND”, swapping between them. RESULTS AND DISCUSSION: According to Abu-Rumeileh et al. (2021), patients with COVID-19, even if asymptomatic, were more likely to develop GBS, with a predominance of the male population, in the classic sensorimotor form and in acute inflammatory demyelinating polyneuropathy, with an increase in pediatric cases also being observed, due to of the wide age range of Sars-Cov-2. The post-infection immune-mediated pathophysiological mechanism observed some predisposing factors, namely: neurological symptoms after Sars-Cov-2 infection, improvement of the clinical picture of GBS with immunomodulators and absence of viral RNA in the cerebrospinal fluid. CONCLUSION: Guillain-Barré Syndrome consists of an immune-mediated neuromuscular condition usually subsequent to an infectious process, which triggers an inflammatory response followed by a molecular mimicry that causes an autoimmune response in the individual's peripheral nervous system. Although there is no consensus in the scientific community regarding the causal relationship between COVID-19 and GBS, it is believed that infection with the new coronavirus precipitates an immune-mediated reaction that triggers this neuromuscular condition characterized by progressive, symmetrical and ascending weakness, in addition to areflexia.
Challenges and successes: online and inclusive teaching of green chemistry in Brazil in the time of covid-19
Authors: Da Silva Júnior Carlos Alberto , Souza Niely Silva de , Velozo Maria Caroline Santos , Ferraz Júlia Maria Soares , Tavares Márcio Jean Fernandes , Figueirêdo Alessandra Marcone Tavares Alves de
Published: January 2023

The year 2020 was marked by the beginning of the intense journey against Covid-19, which brought strong impacts to Brazilian education. In view of this, the educational system began to adapt to the “new normal” and, with this, problems arose in adapting to virtual education, especially in the scope of School Inclusion (SI) of the deaf public, since social distancing requires significant attention in the use of aspects of communication and online technologies. These difficulties were more prominent, especially in the discipline of Chemistry, which is not detached from experimentation. Thus, the research demonstrates the need for better approaches to SI in Emergency Remote Education (ERE), especially in Chemistry contextualized to Environmental Education (EE). This work aims to adopt Active Methodologies (AM) and it is justified in offering activities aimed at the interassociations between Chemistry and EE, through the Case Study (CS) method. These actions addressed the principles of Green Chemistry (GC) and the 6th Sustainable Development Goal (SDG) on drinking water and sanitation. The development of the work occurred remotely in an inclusive class. The results of the research demonstrated the importance of using inclusive methodologies that favor the construction of effective knowledge and enable the exchange of knowledge in a bilingual and accessible environment. Thus, the adaptation or development of new didactic methodologies can change the reality of Brazilian education.
Primary care and vaccination
Authors: Dias Reis Lidiane , Oliveira Richardson Lemos de , Santana Wilder Kleber Fernandes de , Bernardelli Maiton , Dalpiaz Altemir Luiz , Ribeiro Luciana Quagliane , Freitas Vinicius da Silva , Ruela Guilherme de Andrade , Lucena João Batista , Peixoto Hugo de Andrade , Sousa Cristiane Moreira de , Reis Dandara Ferreira , Schräder Josele da Rocha , Chelucci Rose Procopio , Capistrano Andréa , Nobrega Luiz Leonardo Louzada , Brandão Paula Paraguassu
Published: January 2023

The present research delimited as objective to carry out an investigation on the challenges encountered by Primary Health Care and its Contributions with regard to vaccination for the control and immunization of the population. It is essential to consider contemporary narratives - national and international - that orbit around the central axis “Primary care and vaccination”, which consisted of: immunization; population management; quality of life; contributions; challenges and vaccine coverage, in a timeline from 2019 to 2022. As challenges, we deal with disinformation, or even fake news, which confuse the population, leading them to disbelieve in the vaccine potential. Finally, we analyze what have been the main contributions of primary care to improve the implementation of vaccine management. We resort to portals such as the World Health Organization (WHO), the Ministry of Health of Brazil and articles from the Vitrual Health Library to strengthen that, in Primary Health Care, vaccination services offer important evaluation indicators, which have been demonstrating, as over time, the contribution of vaccination actions to the health sector, characterizing them as one of the most rewarding, in view of the impact on disease control.
Bacterial nanocellulose and long-chain fatty acids interaction
Authors: Oviedo Vinícius Rodrigues , Zancan Tonel Mariana , Paixão de Souza Filho Walter , Rodrigues Jr. Luiz Fernando , Rorato Sagrillo Michelle , Binotto Fagan Solange , Da Silva Fernandes Liana
Published: January 2023

Chronic wounds are a big challenge in contemporary society, as they lead to a decrease in life-quality, amputations and even death. Infections and biofilm formation might occur with chronic wounds, due to the higher susceptibility to antibiotic multi-resistant bacteria. In this situation, novel wound dressing biomaterials are needed for treatment. Thus, the aim of this research was to evaluate a possible BNC interaction with tucumã oil/butter-derived fatty acids, as this system could be a promising biomaterial for wound treating. The interaction between  cellobiose (BNC basic unit) and four fatty acids was evaluated by ab initio simulations and density functional theory (DFT), through SIESTA code. Molecular docking was also used to investigate the effect of a possible releasing of the studied fatty acids to the quorum-sensing proteins of Pseudomonas aeruginosa (gram-negative bacterium) and Staphylococcus aureus (gram-positive bacterium). According to ab initio simulations, the interaction between cellobiose and fatty acids derived from tucumã oil/butter was suggested due to physical adsorption (energy around 0.17-1.33 eV) of the lipidic structures into cellobiose. A great binding affinity (∆G ranging from 4.2-8.2 kcal.mol-1) was observed for both protonated and deprotonated fatty acids against P. aeruginosa (LasI, LasA and Rhlr) and S. aureus (ArgA and ArgC) quorum-sensing proteins, indicating that these bioactive compounds might act as potential antimicrobial and/or antibiofilm agents in the proposed system. Hence, from a theoretical viewpoint, the proposed system could be a promising raw biomaterial in the production of chronic wound dressings.
We are loaded for bear! The use of zoo holiday camp for environmental education.
Authors: Rodrigues Karlen , Oliveira Sereia Diesse Aparecida de , Esser Tenfen Camila , Carolina Patusse Ana , Luciane Kovalski Mara , Haas. Jucelaine
Published: January 2023

Environmental Education in non-formal educational spaces emerges as a tool capable of making people aware of the importance of conserving natural resources. The present study aimed to evaluate the potential of a holiday camp as a tool to promote non-formal environmental education. For 5 days, a total of 19 children between 9 and 12 years old, participated in various activities held in a zoo, located in the city of Dois Vizinhos, Paraná. The research had a qualitative and descriptive character and the field diary and participant observation were used for data collection. The results indicate that the children were made aware of the importance of all animals to the ecosystem and at various times presented critical thinking about the problems caused by man to the environment. It is hoped that the activities developed can collaborate in the process of formation for change, in which people can change their relationship with the environment, not only in their daily attitudes, but as future citizens of rights who demand economic and social transformations for the conservation of natural resources.
Utility Model Patent Protection Scenario in Brazil and the Indication Of Excessive Rigor in the Inventive Examination
Authors: Ramos Eloy Bruno , Belmino dos Santos João Antonio , Barbosa da Cruz Cleide Ane , Da Silva Quintino Heliana Mary , Sobral Garcez Júnior Sílvio , Oliveira Uchôa Fábio
Published: January 2023

Studies on utility model patents have shown this as an alternative for rapid patent protection that contributes to promoting the country's economic development. Therefore, this research aims to propose a study of the utility model patent in the national patent system, aiming to know if this type of protection has served the purpose of innovative and technological evolution verified in countries with developing economies similar to Brazil. Regarding the methodology, this study is characterized by a quantitative exploratory study that was divided into two phases. The first phase was a bibliographic research related to utility model and the second phase was the analysis of applications for patents of invention and utility model. The results show that there is a greater amount of invention patent filings than utility model patent filings between 2000 and 2019. Also, it was noted that there is a significant decrease in the share of the utility model in the total of analyzed filings, as well as the PI deferral rate is higher than that of the MU in most of the cataloged years. As for the literature and jurisprudence analyzed, it was noticed that the inventive level required for the utility model patent is of lower intensity than that required for invention patents. Therefore, an accurate and objective definition of the inventive act requirement is suggested, in order to distinguish it precisely from the inventive step requirement, in order to speed up the analysis process and increase the demand for utility model patent filings.