bluuebunny/crossref_metadata_2025 huggingface dataset:
The Natural Sweetener Stevia: An Updated Review on its Phytochemistry,
Health Benefits, and Anti-diabetic Study
Authors: Patel Shraddha , Navale Archana
Published: May 2023

Stevia rebaudiana Bertoni is one of the significant high qualities of non-caloric sugar
substitute sweetener plants against diabetes disease. Diabetes mellitus is one of the most common
metabolic diseases caused by insulin secretion defects, insulin resistance in peripheral tissues, or
both. Stevia rebaudiana is a perennial shrub of the Compositae family that is grown in several
places around the world. It contains a plethora of different bioactive constituents which are responsible
for several activities and sweetness. This sweetness is due to the presence of steviol glycosides
which is 100-300 times sweeter than sucrose. Furthermore, stevia reduces oxidative stress,
lowering the risk of diabetes. Its leaves have been used to control and treat diabetes and a variety
of other metabolic diseases. This review summarizes the history, bioactive constituents of S. rebaudiana
extract, pharmacology, anti-diabetic activity, and its application, especially in food supplements.
A Comprehensive Review of Modern Methods for Load Prediction in the
Smart Grid
Authors: Attiwal Pushpa , Indora Sanjeev
Published: May 2023

:

Load forecasting plays a crucial role in mitigating risks for utilities by predicting future
usage of commodity markets transmission or supplied by the utility. To achieve this, various techniques
such as price elastic demand, climate and consumer response, load analysis, and sustainable
energy generation predictive modelling are used. As both supply and demand fluctuate, and weather
and power prices can rise significantly during peak periods, accurate load forecasting becomes
critical for utilities. By providing brief demand forecasts, load forecasting can assist in estimating
load flows and making decisions that prevent overloading. Therefore, load forecasting is crucial in
helping electric utilities make informed decisions related to power, load switching, voltage regulation,
switching, and infrastructure development. Forecasting is a methodology used by electricity
companies to forecast the amount of electricity or power production needed to maintain constant
supply as well as load demand balance. It is required for the electrical industry to function properly.
The smart grid is a new system that enables electricity providers and customers to communicate
in real-time. The precise energy consumption sequence of the consumers is required to enhance the
demand schedule. This is where predicting the future comes into play. Forecasting future power
system load (electricity consumption) is a critical task in providing intelligence to the power grid.
Accurate forecasting allows utility companies to allocate resources and assume system control in
order to balance the same demand and availability for electricity. In this article, a study on load
forecasting algorithms based on deep learning, machine learning, hybrid methods, bio-inspired
techniques, and other techniques is carried out. Many other algorithms based on load forecasting
are discussed in this study. Different methods of load forecasting were compared using three performance
indices: RMSE (Root Mean Square Error), MAE (Mean Absolute Error), MAPE (Mean
Absolute Percentage Error), and Accuracy. Machine learning-based techniques showed a reduction
of 9.17% in MAPE, 0.0429% in RMSE, and 5.23% in MSE, and achieved 90% accuracy. Deep
learning-based techniques resulted in a 9.61% decrease in MAPE and achieved 91% accuracy. Bioinspired
techniques provided a reduction of 9.66% in MAPE, 0.026% in RMSE, and 5.24% in
MSE, and achieved 95% accuracy. These findings concluded that optimization techniques are more
encouraging in predicting load demand and, as a result, can represent a reliable decision-making
tool.
Microspheres: A Novel Approach for Sustained Colon Targeted Drug
Delivery
Authors: Jaunjalkar Vaibhavi , Chopade Shakuntala
Published: May 2023

Colon targeted medication delivery is a field of study for disorders including colon can-cer and inflammatory bowel disease (IBD), with the goal of delivering localised therapy with mini-mal systemic damage. In recent decades, the global prevalence of colonic problems has increased, demanding more local treatment of colonic disorders, which will lead to the development of more effective and safe pharmaceutical regimens. When developing a formulation for colonic administra-tion, it's critical to consider both the physiological characteristics of the colon and the environment surrounding the disease site (s). The GI tract experiences dynamic changes in motility, fluid vol-ume, enzyme activity, and pH from the stomach to the intestine. The current review focuses on Bio-degradable polymers or protein‑based microspheres having free‑flowing properties and particle size 5200 nm have a variety of advantages over conventional colon targeted drug delivery systems. Dur-ing drug transit through the GIT, polysaccharides maintain their integrity and inhibit drug release. When it comes into contact with colonic fluid, however, it is attacked by anaerobic microbes, and the imprisoned medication is released. In this review, several methods of microsphere formulation and characterization were investigated along with its in vitro and in vivo study methodology.
Review on Diabetes Mellitus: An Insight into the Current Scenarios, the Challenges of Therapy, and Application of Traditional Drugs
Authors: Mishra Ashwini Kumar , Pandey Mukesh , Pannu Arzoo , Dewangan Hitesh Kumar , Sahoo P.K.
Published: May 2023

Diabetes mellitus, an epidemic of the 21st century, is listed as one of the top ten causes of death around the world by the World Health Organization and is a complicated disease to deal with. Medically, a metabolic disorder characterized by elevated blood glucose levels and altered metabolism of biological macromolecules, mainly carbohydrates. Diabetes mellitus has a worldwide prevalence, and populations of all high, middle, as well as low-income countries, are affected by it. More than 400 million persons are currently living with diabetes. Many risk factors, such as lack of exercise, irregular diet, drinking, and smoking habits, as well as genetic factors, also contribute to the increased incidence of diabetes mellitus in the modern era. The conventional therapies for diabetes are based on insulin, insulin analogues, peptides, and oral hypoglycemics. The primary objective is to lower the elevated blood glucose levels and manage the distress to enhance the quality of life of the patient. The management of diabetes is very crucial to avoid complications having serious consequences such as the extra economic burden due to these complications. Conventional drug therapy has its own adverse effects, and its timely availability and cost are still an issue in many low and middle-income countries. Diabetes mellitus has been reported in various ancient kinds of literature along with various natural remedies (plants/herbals) useful in it. These plant-based remedies offer the benefits of lesser or no adverse effects, easy availability due to natural abundance, and low cost. Therefore, extensive research work is carried out in the past few decades to identify and understand the underlying principles of plant-based/herbal medicines to develop new potential lead molecules and a relatively safer, easily available and more economical alternative treatment therapy for diabetes mellitus.
Permittivity-customizable Low-cost Laminated PET Sheet Multilayer Substrate
to Design Flexible and Conformal Planar Inverted F Antenna
Authors: Maithani Sachin , Bansal Shivam , Saini Garima , Dhaliwal Balwinder Singh
Published: May 2023

In this article, a Planar Inverted F Antenna (PIFA) has been designed using low-cost
commercially available transparent laminated sheets. Energy Dispersive X-ray (EDX) analysis is
used to acquire the element composition of the transparent laminated sheet.

Methods:

The flexibility is attained using a market-available low-cost Polyethylene Terephthalate
(PET) sheet as a substrate. The dielectric properties of this non-conventional laminated sheet need
to be identified for antenna design and the microstrip ring resonator test method is used to determine
the dielectric properties of the multilayer PET sheets.

Results:

The linear match has been observed on multilayer laminated PET sheets for dielectric
properties and radiation characteristics. Adhesive copper foil of a thickness of 0.08 mm has been
used as for conducting layer on the PET lamination sheet. As per the literature survey, it is evident
that this is the first attempt to use the reported methodology for PIFA design application. The gain
of proposed antenna is 5.2dB.

Conclusion:

The designed flexible antenna has been developed for wearable and IoT applications
in 2.45 GHz ISM band. A good match has been observed between the simulated and measured
characteristics.
Selection of Digital Watermarking Techniques for Medical Image Security by
Using the Fuzzy Analytical Hierarchy Process
Authors: Ahmad Masood , Nadeem Mohd , Islam Mohd , Ali Saquib , Agrawal Alka , Ahmad Khan Raees
Published: May 2023

Background:

The watermarking technique is a security algorithm for medical images and the patient's information. Watermarking is used for maintaining the robustness, integrity, confidentiality, authentication, and complexity of medical images.

Objective:

The selection of medical image watermarking technique is multi-criteria decision-making and an automatic way of algorithm selection for security and privacy. However, it is difficult to select a better watermarking technique through traditional selection techniques.

Methods:

To deal with this problem, a multicriteria-based fuzzy analytic hierarchy process (FAHP) was proposed. This method is applied for algorithm selection for the security of medical images in healthcare. In this method, we first determined the list of criteria and alternatives, which directly affect the decision of the medical image security algorithm. Then, the proposed method was applied to the criteria and alternatives.

Results:

We provided the rank according to the obtained weights of the algorithm. Furthermore, the overall results and ranking of the algorithms were also presented in this article.

Conclusion:

Integrity was found to have the highest weight (0.509) compared to the other criteria. The weight of the other criteria, namely authentication, was 0.165, robustness was 0.151, confidentiality was 0.135, and complexity was 0.038. Thus, in terms of ranking, integrity was reported to be of the highest priority among the five criteria attributes.
Glycosides in the Treatment of Gastrointestinal Tract Cancer
Authors: Alam Waqas , Ahmad Imad , Aschner Michael , Khan Haroon
Published: May 2023

Gastrointestinal (GI) carcinomas are tumors that impact the digestive system
and its supporting organs. Esophageal, gastric and colorectal cancers are among the
common cancers in the gastrointestinal tract. GI cancers are responsible for about 2.7
million deaths of the 8.2 million mortalities that occur from cancers every year around
the globe. Chemoprevention is the method of intervening in this mechanism by
essential dietary control or the addition of nutraceuticals to the daily nutritional intake.
The initial stages of cancer growth, known as oncogenesis, have sparked a lot of
emphasis on the function of dietary food. The intensity of the epidemiological studies
attracted research scholars' interest in the mechanisms underlying the anti-proliferative
activities; however, investigation has indeed discovered lots of new phytochemicals in
vegetables and fruits which might prevent the development of carcinogenesis. In cancer
treatment, drugs obtained from plant sources have a significant role in cancer
treatment. The plant alkaloids isolated from Catharanthus roseus, such as vincristine
and vinblastine, are clinically used to treat testicular carcinomas, leukemia, and breast
cancer. Paclitaxel is isolated from Taxus brevifolia and is used in the management of
lung cancer, breast cancer and ovarian cancer. In the 1960s, there has been initial proof
of the in vitro cytotoxic impact of glycosides on human cancer cell lines and their in
vivo anti-tumor activities. Cardiac glycosides are Na+
/K+ATPase inhibitors and elevate
the Ca+2 concentrations, which in turn leads to a positive inotropic effect and is thus
used as cardio-tonic in the management of congestive heart failure. Cardiac glycosides
have recently been documented to play roles in initiating, developing and metastasizing
the tumor by controlling cell viability and mortality pathways. It has been reported that
Na+
/K+ATPase inhibitor causes cell death by inducing autophagy, apoptosis and
synthesis of free radical species. Notwithstanding the advances in cancer treatments,
the need for new medicinal products and treatments to enhance their effectiveness and
to decrease the toxicity of existing regimes is strong and unequaled, although a broad
objective is to improve the therapeutic results of GI cancers. This chapter briefly
describes the glycosides, gastrointestinal malignancies and the diverse types of glycosides involved in the management of GI malignancies and the clinical trials under
progress for the clinical efficacy. 
Phytosterols in the Treatment of Gastrointestinal Tract Cancers
Authors: Akkol EsraKüpeli , Acıkara OzlemBahadır
Published: May 2023

Phytosterols and related derivatives phytostanols are naturally occurring
bioactive compounds present mainly in plant cell membranes. These lipophilic steroid
alcohols contain a tetracyclic cyclopenta [a] phenanthrene structure which is
substituted with a hydroxyl group at position C3 and have a side chain at position C17,
usually containing one or more double bonds in the steroid skeleton. Phytosterols
derived from isopentenyl pyrophosphate belong to the terpene family and are generally
synthesized by the mevalonate pathway. They have similar structural and biological
functions to cholesterol. It is not possible to synthesize by a human; as a result of their
intake in diet, they are present in the human body as cereals, legumes, vegetables,
fruits, nuts, vegetable oils, oilseeds, cereal grains, cereal-based products and related
products which contain phytosterols in relatively high amount, consumed daily by the
whole world population. Phytosterols are known as part of the normal human diet.
Increasing interest has been given to phytosterols in recent years as epidemiological
and experimental studies suggest that they have an important role in the protection
from cancer besides their several beneficial effects, such as anti-inflammatory,
antioxidative, anticarcinogenic, antifungal, antibacterial, antipyretic, antineoplastic,
anti-ulcerative activity and cholesterol-lowering capacity. Inhibition tumor cell growth,
multiplication, invasion and metastasis; reducing cell proliferation and increasing
apoptosis; decreasing tumor size; inhibition of carcinogen production; reduction of
angiogenesis and adhesion of cancer cells; inhibition of reactive oxygen species
production and oxidative stress and increased antioxidant enzymes have been
suggested as responsible mechanisms for anticancer activity of phytosterols. The
current review aims to summarize the occurrence, safety, toxicity and chemistry of
phytosterols to explain their potential activities in cancer with suggested mechanisms in
detail. Furthermore, epidemiological and experimental studies related to treating the
activity of phytosterols in gastrointestinal system cancers have been described. 
Multi-functional Ligands and Molecular Hybridization: Conceptual Aspects and Application in the Innovative Design of Drug Candidate Prototypes for Neurodegenerative Diseases
Authors: de Freitas Silva Matheus , Dias Viegas Flávia Pereira , Silva Gontijo Vanessa , Cristancho Ortiz Cindy Juliet , Reis Rosa Franco Graziella dos , Tomás Ernesto Januário , Damásio Caio Miranda , Pinto da Silva Fonseca Gabriel , Fernandes Silva Isabela Marie , Emika Massuda Larissa , Fernanda da Silva Maria , Thâmara Gaspar Campos Thâmara Gaspar Campos , Mota Braga Priscila da , Viegas Claudio
Published: May 2023

The rapid increase in the incidence of dementia has enormous socioeconomic impacts and costs for governmental health systems all over the world.
Despite this, finding an effective treatment for the different types of neurodegenerative
diseases (NDs) so far represents a challenge for science. The biggest obstacles related
to NDs are their multifactorial complexity and the lack of knowledge of the different
pathophysiological pathways involved in the development of each disorder. The latest
advances in science, especially those related to the systems biology concepts, have
given new insights for a better comprehension of such multifactorial networks related
to the onset and progression of NDs, and how Medicinal Chemists could act in the
search for novel disease-modifying drug candidates capable of addressing the multiple
pathological factors involved in neurodegeneration. The multi-target directed ligands
(MTDLs) concept has captivated and opened new windows for the creativity and
rationality of researchers worldwide in seeking innovative drug candidates capable of
modulating different molecular targets by a single multifunctional molecule. In fact, in the last two decades, thousands of research groups have dedicated their efforts to the
use of molecular hybridization as the main tool for the rational design of novel
molecular scaffolds capable of expressing multi-target biological activity. In this way,
this chapter addresses the most recent pathophysiological hallmarks of the most high-impact NDs, represented by Alzheimer’s, Parkinson’s, Huntington’s diseases, and
amyotrophic lateral sclerosis, as well as the state-of-art in the design of new MTDLs,
inspired mostly by natural products with improved druggability properties.
Phytosome for Targeted Delivery of Natural Compounds: Improving Efficacy, Bioavailability, and Delivery across BBB for the Treatment of Alzheimer's Disease
Authors: Tiwari Prashant , KM Geetha , Shrivastava Shweta , Kumari Yogita , Panik Rajni Kant , Kumar Singh Pankaj , Kumar Dileep , Kumar Sahu Pratap
Published: May 2023

Alzheimer’s disease (AD) is a progressive neurological disorder. Recent
studies show that AD is the most common cause of dementia. There are several
symptomatic treatments available to counterbalance the neurotransmitter disturbance.
Currently, cholinesterase inhibitors are available for the treatment of mild to moderate
AD. In addition to that, memantine (an N-methyl-D-aspartate receptor non-competitive
antagonist) is also available for moderate to severe AD. Poor blood-brain barrier
permeability is a limitation of existing drugs. These drugs may slow the disease
progression, but there are chances of reoccurrence of the disease. Several medicinal
plants such as Jasminum sambac, Rosmarinus officinalis, Eucalyptus globulus, Nigella
sativa, and Acorus gramineus are reported to have neuroprotective effects. Salvia
officinalis has cholinergic binding properties. Ginger root extract may prevent
behavioral dysfunction in AD. Extensive research on these plants should be carried out.
Drug delivery systems such as lipid nanoparticles, polymer nanoparticles, nano-micelles, nano-gels, liposomes, phytosomes, etc., could significantly improve the
pharmacokinetics, stability, efficacy and reduce the side effects. Phytosomes have the
advantage over other drug delivery systems to selectively target the drugs into the
brain. In contrast to traditional approaches, polar phytoconstituents loaded phytosomes are more bioavailable on the site of brain tissue, as they can easily go for systemic
circulation crossing the Blood-Brain Barrier (BBB). Phytosomes have a low hazard
profile as toxicological outcomes are negligible and assure duration of action at a low-risk profile due to upgraded absorption of the active constituents. In addition to this, the
improved pharmacodynamic properties of phytosomes make them suitable for the
treatment of neurological disorders.
Alzheimer’s Disease and Physical Activity, Will the Symptoms Improve?
Authors: Hamzeloo-Moghadam Maryam
Published: May 2023

 Alzheimer’s disease is known to be the most common cause of dementia
with increasing number of people suffering every year. In healthy adults, there are
millions of neurons in the brain. Degeneration starts and extends in Alzheimer's disease
many years before the initial symptoms show up. The neurons taking part in cognitive
functions destroy gradually leading to functional disability and finally to death. β amyloid plaques and tau protein are known as the most responsible causes of
Alzheimer’s disease resulting in neurodegeneration. Inflammation, atrophy and
dysfunction in glucose metabolism will follow. The three stages of the disease include
mild, moderate and severe. The patient will have difficulty in cognitive functions, show
changes in behavior and will need care for everyday needs, which increases by the
disease progress. There are pharmacologic and non-pharmacologic approaches for
treatment. The pharmacologic approaches comprise acetylcholinesterase (AChE)
inhibitors such as donepezil or N-methyl-d-aspartate (NMDA) receptor blockers like
memantine. None of them stops the disease but alleviate the symptoms. On the other
hand, non-pharmacologic approaches are usually used to improve the patient’s quality
of life or improve the behavioral aspects of the disease. Recently, involving physical
activity as a non-pharmacologic method of treatment for Alzheimer’s disease has been
the focus of many studies. This chapter will have a glance at the clinical trials that were
conducted regarding the effect of physical exercise and its impact on Alzheimer’s
disease.
Pattern Recognition Receptors in Brain: Emphasis on Toll Like Receptors and their Types
Authors: Krishnan Jayalakshmi
Published: May 2023

The immune system is highly complex; it senses foreign invaders, thus
protecting the body. The adaptive arm of the immune system confers long-term
protection, whereas the innate immune system confers immediate protection. In the
case of the immune system, the pattern recognition receptors offer various modes of
sensing the pathogen-associated molecular patterns present in pathogens. The receptors
that sense invading pathogens are called Pattern recognition receptors [1]. The adaptive
immune system is very sophisticated, as it is trained to identify only the “specific
antigen”, but PPRs are customised to sense a wide array of “common patterns” present
in the pathogens. Cerebral pericytes are the cells that are seen as embedded in the
basement membrane of capillaries. Matzinger [2] gave a new insight into the
recognition of pathogens by PRRs as those that recognise PAMPs and DAMPs
(Damage Associated Molecular Patterns). While PAMPs can be presented as
exogenous ligands to the receptor, DAMPs are presented as endogenous ligands. Once
these PRRs are activated either by PAMPs or DAMPs, they lead to the production of
inflammation to clear the infection. However, over-activation during chronic conditions
leads to pathological changes.
Analisis Potensi Daun Gamal Sebagai Pakan Kambing Pada Perkebunan Lada Menggunakan Tiang Pohon Gamal (Gliricidia sepium)
Authors: Amin Muhtar , Syahrir Syahrir , Junaedi Junaedi
Published: May 2023

Analisis kapasitas daya tampung dari produksi gamal dalam satu hektar pada pertanian lada berpenyangga pohon gamal dapatdijadikan sebagai indikator dasar jumlah ternak kambing yang dipelihara pada sistem integrasi tanaman lada dengan ternak kambing. Tujuan penelitian ini untuk mengetahui bagaimana daya dukung daun gamal pada perkebunan lada berpenyangga pohon gamal terhadap pengembangan peternakan kambing. Rataan luas lahan petani lada dengan menggunakan gamal sebagai penanggah yaitu 2,98±0,58 hektar/keluarga, jumlah tiang gamal 3.261±630,21 pohon, dan jarak tanam 3m x3m (9 m2).Produksi daun gamal 13,14±2,99 kg/pohon/panen, produksi gamal per hektar yaitu 62.767,9±19.935,78 kg/tahun (62,76 ton/tahun).Kapasitas daya tampung daun gamal dari produksi 15.880 kg/hektar/tahun bahan kering yaitu sebanyak 44 ekor kambing/tahun. Berdasarkan hasil penelitian dapat disimpulkan bahwa untuk satu hektar lahan perkebunan lada yang menggunakan penyangga pohon gamal dengan jarak tanam 3 m x 3m,dapatmemproduksi daungamal dengan bahan kering 15.880 kg/tahun dan mampu memenuhi kebutuhan ternak sebanyak 44 ekor.
Evaluasi Evaluasi Penggunaan Kombinasi Aditif Berbasis Molases dan Sirup Komersial Afkir yang Dapat Menstimulasi Pertumbuhan Mikroba Baik Terhadap Profil Fermentasi Silase Tebon Jagung
Authors: Sadarman Sadarman , Handoko Jully , Febrina Dewi , Febriyanti Rahmi , Purba Rovi , Ramadhan Endo Surya , Qomariyah Novia , Gholib Gholib , Nurfitriani Rizki Amalia , Adli Danung Nur , Khairi Fitrah
Published: May 2023

Biomassa tanaman jagung masih mengandung nutrisi tinggi sehingga potensial dijadikan sebagai bahan pakan, namun kadar air biomassa ini tinggi dan mudah rusak sehingga perlu diawetkan. Penelitian ini bertujuan untuk mengetahui profil fermentasi silase tebon jagung yang diensilase menggunakan kombinasi aditif molases dan sirup komersial afkir (SKA). Metode eksperimen dengan Rancangan Acak Lengkap terdiri atas 5 perlakuan dan 5 ulangan sebagai berikut: P1: Tebon Jagung + Molases 100% BK (26,3 g), untuk P2, P3, P4, dan P5 masing-masing ditambah dengan sirup komersial afkir sebanyak 25%, 50%, 75%, dan 100% BK sebagai pengganti molases, selanjutnya diensilasekan selama 30 hari. Parameter yang diukur adalah persentase pertumbuhan jamur, pH, kandungan amonia, total VFA, dan nilai fleigh. Data dianalisis dengan analisis ragam. Perbedaan nilai antar perlakuan diuji lanjut dengan DMRT taraf 5%. Hasil penelitian ini menunjukkan penggunaan sirup komersial afkir sebagai pengganti molases memberikan pengaruh yang nyata (P<0,05) terhadap pH, persentase pertumbuhan jamur, kandungan amonia, produksi toal VFA, dan nilai fleigh silase tebon jagung. Penggunaan SKA 100% BK (26,3 g) menghasilkan silase tebon jagung dengan persentase pertumbuhan jamur sekitar 0,53%, kandungan amonia sekitar 2,30 mM dengan nilai fleigh sekitar 113. Silase tebon jagung dengan nilai pH terbaik pada penggantian molases dengan SKA sebanyak 75% atau sekitar 19,7 g, sedangkan produksi total VFA silase tebon jagung tertinggi sekitar 58,1 mM yang menggunakan SKA sebanyak 50% (13,1 g) sebagai pengganti molases. Kesimpulan dari penelitian ini adalah SKA dapat dijadikan sebagai aditif silase pengganti molases.
Potensi Keragaman Genotipe Lokal Tanaman Koro Benguk (Mucuna pruriens) Sebagai Tanaman Pakan Ternak
Authors: Sulistyo Hanief Eko , Putri Choerunnissa Eka , Kamaliyah Siti Nurul , Sudarwati Herni
Published: May 2023

Penelitian ini bertujuan untuk memperoleh informasi tentang keragaman sifat kuantitatif produksi hijauan beberapa genotipe lokal koro benguk (Mucuna pruriens) sebagai bahan seleksi perbaikan genetik tanaman. Benih dari 3 genotipe lokal koro benguk asal Sidoarjo, Surabaya, dan Ponorogo, ditanam dalam polybag (150 polybag untuk setiap genotipe lokal) selama 60 hari. Sifat produksi hijauan yang diamati adalah panjang batang, jumlah daun, bobot batang, bobot daun, dan berat hijauan. Sifat kuantitatif masing-masing genotipe lokal dianalisis untuk mengetahui keragaman dan potensinya sebagai bahan seleksi. Hasil penelitian menunjukkan bahwa genotipe lokal asal Sidoarjo, Surabaya, dan Ponorogo memiliki keragaman dan potensi yang luas pada semua sifat kuantitatif yang diamati. Dapat disimpulkan bahwa ketiga genotipe lokal koro benguk (Mucuna pruriens) memiliki keragaman dan potensi yang tinggi untuk digunakan sebagai bahan seleksi yang efektif untuk pemuliaan hijauan.
Perculiarities of yellow luminescence decay kinetics in LiF-UO-=SUB=-2-=/SUB=- crystals
Authors: Schepina L.I  , Ivanov N.A.  , Ruhgnikov L.I.  , Hramtsova A.A.
Published: May 2023

A fast component, on the order 387 ns (300 K), has been detected in the decay kinetics of the yellow luminescence (563 nm) in LiF-UO2 crystals. It is shown that the emitting centers are anisotropic formations oriented in the crystal lattice along the second-order symmetry axes (C2) using the method of azimuthal dependence of the luminescence polarization. A model of the radiating centre is proposed and the position of the oxygen defect excited level is determined, from which the transition of an electron to the conduction band occurs. The luminescence (387 ns) from of the U5+ ion is observed as a result of electron transfer from oxygen ion to the excited U6+ level. The subsequent hole localization on U5+ in the ground state is accompanied by the reduction of the U6+ ion, that luminescence is observed in the green region of the spectrum (523 nm) with time decay 100 microsecond. Keyword: decay kinetics of luminescence, polarization, LiF-UO2 crystals.
Formation of molecular clusters of silver by polymer-salt method in porous glasses
Authors: Saratovskii A.S.  , Girsova M.A.  , Anfimova I.A.  , Antropova T.V.
Published: May 2023

A methodology for the formation of molecular clusters of silver in silicate nanoporous glasses has been developed. Composite materials containing molecular clusters of silver, silver nanoparticles and zinc oxide have been synthesized. The synthesis was carried out by impregnation of porous glasses in aqueous solutions of silver and zinc nitrates stabilized with high-molecular polyvinylpyrrolidone, followed by heat treatment of samples for decomposition of metal nitrates and polymer. Spectral-luminescent properties of composites have been investigated. Keywords: porous glass, zinc oxide, silver molecular clusters, silver nanoparticles, spectral-luminescent properties.
Spectral methods for study of the G-protein-coupled receptor rhodopsin. III. Osmotic stress effects
Authors: Struts A. V.  , Barmasov A. V.  , Brown M. F.
Published: May 2023

We review osmotic stress studies of the G-protein-coupled receptor rhodopsin. Despite the established presence of small amounts of structural water in these receptors, the influence of bulk water on their function remains unknown. Investigations of osmotic stress effects on the GPCR archetype rhodopsin have provided unique data about the role of water in receptor activation. It was discovered that osmolytes shift the rhodopsin equilibrium after photoactivation, either to the active or inactive conformations depending on their molar mass. Experimentally at least 80 water molecules have been found to enter rhodopsin in the transition to the active state. We propose that this influx of water is a necessary condition for receptor activation. If the water movement is blocked, e.g., by large osmolytes or by dehydration, then the receptor does not undergo its functional transition. The results suggest a new model whereby rhodopsin becomes swollen and partially unfolded in the activation mechanism. Water thus acts as a powerful allosteric modulator of functioning for rhodopsin-like receptors. Keywords: G-protein-coupled receptors, membranes, optical spectroscopy, rhodopsin, signal transduction.
Arrays of Quasi-One-Dimensional GaAs Nanocrystals Grown on the Oxidized Surface of the Si/GaAs(001) Heterostructure: Effect of the Si Epitaxial Layer on the Array Structure
Authors: Emelyanov E. A.  , Del’ T. A.  , Petrushkov M. O.  , Nastovjak A. G.  , Spirina A. A.  , Gavrilova T. A.  , Semyagin B. R.  , Vasev A. V.  , Putyato M. A.  , Preobrazhenskii V. V.
Published: May 2023

Structures with arrays of planar and tilted quasi-one-dimensional GaAs nanocrystals have been grown on GaAs(001) substrates. An epitaxial silicon layer oxidized in air was used as a passivation coating. The amount of silicon deposited varied from structure to structure and was equivalent to 1, 2, 4, and 6 atomic layers. It has been found that in the case of a passivation layer based on silicon with a thickness of 1 atomic layer, an array of planar nanocrystals is formed, and in other cases, inclined quasi-one-dimensional nanocrystals. Nanocrystals are surrounded by crystallites, the shape, size, orientation, and distribution density of which change with the amount of silicon. The lowest density of crystallites was achieved with a silicon layer 6 atomic layers thick. Keywords: molecular-beam epitaxial, GaAs, Si, quasi-one-dimensional nanocrystals, vapour-liquid-crystal.
षासकीय आदिवासी वसतीगृह योजनेचा चिकित्सक अभ्यास
Authors: पुपलवाड कैलाष भीमराव
Published: May 2023

.
FACTORS AFFECTING INTEGRATION OF ICT IN SECONDARY EDUCATION-A CASE STUDY
Authors: Behera Rachita
Published: May 2023

Information and communication technology (ICT), which includes radio, television, and newer digital technologies like computers and the internet, are potentially significant instruments for expanding formal and nonformal educational possibilities to everyone. It enables the adoption of reducing teaching approaches as well as meaningful content that engages pupils. The purpose of this study is to identify the essential aspects that influence the effective use of ICT in secondary education from the perspectives of teachers. A questionnaire-based survey was undertaken, and the relevance of these aspects was examined from the perception of teachers. The research was carried out at number of secondary school in Dhenkanal district of Odisha. The results of the data analysis indicated that different types of respondents ascribed considerably varying weight to criteria related to efficient ICT use. The investigation also discovered other elements that looked to be impediments to ICT usage. Teachers must be familiar with the usage of ICT in their subject areas in order to assist students in learning more successfully. The findings might be beneficial to any institution considering incorporating ICT into its curriculum. This article explored the different factors of ICT in secondary education in the twenty-first century.
A COMPARATIVE STUDY ON BODY IMAGE AND BODY SHAPE CONCERNS AMONG URBAN COLLEGE GIRLS OF DELHI AND UTTAR PRADESH
Authors: . Babita , Satsangi Ekta Bhushan
Published: May 2023

Body image is a type of anticipation of an individual with its self physical, sensation and thoughts. These sentiments can be negative as well as positive or both type are influenced by individual atmosphere factor.
भारतातील स्त्रियांची अवस्था आणि दिशा
Authors: शिंदे छाया   शशिपाल
Published: May 2023

'तदेतत् अर्धद्विदलं भवति' स्त्री-पुरुष समान आहेत असं वरील संस्कृत वचनातून सांगितलं असलं, तरी प्राचीन काळापासून आजपर्यंत नेहमीच स्त्री श्रेष्ठ की पुरुष श्रेष्ठ असा वाद सुरूच आहे. आजच्या काही स्त्रियांनी अतिउच्च प्रगती करून देशाच्या विकासातील आपला वाटा उचलला. प्राचीन काळी आध्यात्म मार्गातील धोंड म्हणून स्त्रीला शिक्षणाचा अधिकार नाकारला होता. तर त्या आधीच्या काळात मैत्रेयी, गार्गी यासारख्या ब्रह्मवेत्त्या स्त्रिया, अनेक ऋषी पत्नींनी समाजाची उत्कृष्ट व्यवस्था लावली. कारण वेद काळातही स्त्रियांना शिक्षण देण्यात येत होते. जेव्हा कोणाला तरी श्रेष्ठ ठरविण्याचा आग्रह होतो तेव्हा दुसरा आपोआपच कमी प्रतीचा किंवा आश्रित होतो. वैदिक विचारधारेने स्त्री-पुरुष दोघांनाही समान ठरविले आहे. म्हणून भारतीय लोक स्त्रीला अर्धांगिनी मानतात. प्रत्येक कार्यात तिला बरोबरीचे स्थान दिले जाते. यज्ञ, लग्न करतांना प्रत्येक ठिकाणी स्त्री पुरुषाच्या बरोबर असते. इंग्रजी भाषेतही स्त्रीला ‘बेटर हाफ’ (Better half) ठरवून समानतेचा दर्जा दिलेला दिसतो.
EFFECT OF AQUO-N-PROPANOL SOLVENT SYSTEMS ON THE MEDICINAL EFFICIENCY OF HEAVY PROPIONATES
Authors: Verma Sanno
Published: May 2023

For highlighting the Solvent-effect of a diapolar aprotic solvent, n-propanol on the biochemical behaviour of propionate ester, the kinetics of alkali catalysed hydrolysis of butyl propionate was carried out in aquo-n-propanol solvent systems having different concentration of the organic component (n-propanol) varying from 20 to 80% (v/v) at different temperatures ranging from 20 to 40°C. The number of water molecules associated with the activated complex of the reaction were found to increase from 0.338 to 1.401 and from this, it is it inferred that n-propanol acts as structure breaker of water converting its dense form into bulky form and it changes the mechanistic path way of the reaction from bimolecular to unimolecular, From the numerical value of the kinetic temperature of the reaction, which is evaluated to be 281.0, it is concluded that there is weak but appreciable interaction between solvent and solute in the reaction media.
KINDNESS IN COLLABORATION
Authors: Lobo Mildred
Published: May 2023

Recent years have seen a great amount of research on collaboration, collaborative learning and collaborative activities in which students essentially work in small groups. Collaborative activities, often organized as project work in schools, are used to develop 21st Century skills in students. Collaboration has been considered as a means to increase student acquisition of content knowledge and develop cognitive skills, like critical thinking and problem solving (Kuhn, 2015). This paper presents the impact of collaboration on developing attributes of kindness among students at middle school level. 152 students from middle school of Bunts Sangha’s S M Shetty International School and Junior College , Mumbai, India participated in the survey. Data has been collected quantitatively and qualitatively through deploying a questionnaire to students. The findings of the study support the use of collaborative activities for developing kindness attributes in students. Such research will further strengthen our understanding of the development of kindness attributes through collaboration and will help educators to maximise the use of collaborative activities to develop kindness attributes in students.
Conceptos básicos : Especies vegetales
Authors: Barragán Hernández Wilson Andrés , Carvajal Bazurto Christian Thomas , Portilla Pinzón Danilo , Upegui Gómez Sara Isabel
Published: May 2023

Árboles multiproposito, árboles maderables, estrato arbustivo, estrato herbáceo.
Variedades de soya e híbridos de maíz para el sistema: variedades de soya
Authors: Tibocha Yuli Stephanie , López Cardona Nathali , González Rodríguez Luis Alfonso
Published: May 2023

Variedades de la soya, características morfológicas diferenciales y oferta varietal de Agrosavia.
Cultivo: enfermedades
Authors: Barona Rodríguez Ayda Fernanda , Antolínez Sandoval Eduar Yovany , Barreto Triana Nancy del Carmen , Vargas Berdugo Angela Maria , López González Ximena
Published: May 2023

Síntomas: presencia de pequeñas manchas amarillentas, alargadas y visibles por ambos lados de la hoja. En el envés de las hojas, aparece un polvillo que contiene el hongo de color naranja o café (dependiendo de la roya que este afectando) que sobresale de la superficie de ellas y es dispersado por el viento.
Assessing Patient Trust in Automation in Health Care Systems: Within-Subjects Experimental Study (Preprint)
Authors: Nare Matthew , Jurewicz Katherina
Published: May 2023

BACKGROUND

Health care technology has the ability to change patient outcomes for the betterment when designed appropriately. Automation is becoming smarter and is increasingly being integrated into health care work systems.

OBJECTIVE

This study focuses on investigating trust between patients and an automated cardiac risk assessment tool (CRAT) in a simulated emergency department setting.

METHODS

A within-subjects experimental study was performed to investigate differences in automation modes for the CRAT: (1) no automation, (2) automation only, and (3) semiautomation. Participants were asked to enter their simulated symptoms for each scenario into the CRAT as instructed by the experimenter, and they would automatically be classified as high, medium, or low risk depending on the symptoms entered. Participants were asked to provide their trust ratings for each combination of risk classification and automation mode on a scale of 1 to 10 (1=absolutely no trust and 10=complete trust).

RESULTS

Results from this study indicate that the participants significantly trusted the semiautomation condition more compared to the automation-only condition (P=.002), and they trusted the no automation condition significantly more than the automation-only condition (P=.03). Additionally, participants significantly trusted the CRAT more in the high-severity scenario compared to the medium-severity scenario (P=.004).

CONCLUSIONS

The findings from this study emphasize the importance of the human component of automation when designing automated technology in health care systems. Automation and artificially intelligent systems are becoming more prevalent in health care systems, and this work emphasizes the need to consider the human element when designing automation into care delivery.
Understanding Employee Voice Behavior Through the Use of Digital Voice Channel in Long-Term Care: Protocol for an Embedded Multiple-Case Study (Preprint)
Authors: Kepplinger Anja , Braun Alexander , Fringer André , Roes Martina
Published: May 2023

BACKGROUND

Specific challenges in the health care sector, such as hierarchical structures, shortages of nursing staff, and high turnover of nursing staff, can be addressed by a change process of organizational culture into shared governance. Data from business organizations show that the use of digital voice channels provides employee voice. This approach makes concrete the opportunity for employees to raise their voices by answering surveys and making comments in an anonymous forum, which subsequently positively influences staff turnover and sick leave. Since there is no clear understanding of how a digital voice channel can be used in long-term care to address employee voice, a research gap has been identified.

OBJECTIVE

The purpose of ADVICE (Understanding Employee Voice Behavior; the acronym for this study) is to understand how the use of a digital voice channel performs in long-term care (residential long-term care and home care facilities). The aim of this study is to understand how the digital voice channel can support staff in making their voices heard and to see what managers need to use the voice channel to change the work environment.

METHODS

An embedded multiple-case study will be used to explore the experiences of 2 health care providers who have already implemented a digital voice channel. ADVICE is organized into two main phases: (1) a scoping review and (2) an embedded multiple-case study. For this purpose, focus group interviews with employees, discursive-dialogical interviews with managers, meeting protocols, and data from the digital voice channel will be analyzed. First, all units of analysis from every embedded unit will be separately analyzed and then comprehensively analyzed to obtain a case vignette from every embedded unit (within-analysis). In the second stage, the analyzed data from the embedded units will be compared with each other in a comparative analysis (cross-analysis).

RESULTS

The results will provide insight into how digital voice channels can be used in long-term care to address employee voice. We expect to find how the digital voice channel can empower nurses to speak up and, consequently, create a better work environment. Data collection began in August 2023, and from a current perspective, the first results are expected in summer 2024.

CONCLUSIONS

In summary, the results may help to better understand the use of a digital voice channel in the health care sector and its transformative potential for leadership. At the organizational level, research can help to improve the attractiveness of the workplace by understanding how to give employees a voice.

INTERNATIONAL REGISTERED REPORT

PRR1-10.2196/48601
Management of the Tourism Offer as an Economic Development Function Bosnia and Herzegovina
Authors: Vidovic Aleksandra
Published: May 2023

It is a known fact that tourism is a natural phenomenon that effects equally both the economic and social development of each country. On the other hand, economic development should provide a steady / constant economic growth. If we look at the economy and tourism in the same light it is said that the two phenomena are unified by one of the most important drivers of growth in the world. Economic results expected from tourism should not be valid unless it is done benchmarking analysis of similar tourist destination, because only comparisons with the best, or at least their own kind (meaning the capacity supply) provides valid information. The main objective of this paper is to show how tourism effects of economic development BiH is also given some basic guidelines on what to conceive of future economic activity, and where the potential exists tourist attractions.
Applying Passive Cooling at an Urban Level: Case Study of Dubai, UAE
Authors: Taleb Hanan M. , Jumah Ghadeer M.
Published: May 2023

This research employs the integrative process of sustainable urbanism by applying passive design strategies to promote a sustainable neighbourhood lifestyle. A selected neighbourhood in Dubai is analysed and assessed in terms of its existing achievements regarding sustainability. It does so by simulating a site’s potential, its limitations, characteristics, existing buildings, transportation status, climate, and the Dubai culture in order to optimize and develop design criteria that meet all the requirements at different levels for a sustainable neighbourhood. To permit this, five passive cooling strategies are applied. The methodology adopted for this study is the assessment of the implications of proposed designs through the use of Envi-met software simulation. As per LEED a variety of facilities are included, and land use is differentiated to enhance social interaction and to meet all the daily needs of community users in such a way as to maximize the potential of a sustainable urban design process compared with the conventional way. The sustainable corridor was also oriented toward the northwest which helped generate many wind loops towards in the direction of the central plaza and the community hall and which increased wind speed by 6m/s. Additionally, in the proposed design, open spaces and green areas were increased by 30% through the creation of a major central plaza, a walkable environment, and water features to enhance livability and comfort in the community. Additional daily facilities and entertainment destinations are provided to capitalize on the proposed open spaces. The study yielded several significant findings; most notable was the reduction of surface temperature by approximately 2.5 degrees centigrade as a result of increasing the green areas by 30% and introducing a large water body and water features on-site.
Los fundamentos antropológicos de la crítica de Rousseau al progreso de las artes y las ciencias
Authors: Marino López Antonio Luis
Published: May 2023

Examen de los argumentos de Rousseau en su Discurso sobre el origen y los fundamentos de la desigualdad entre los hombres para sustentar su crítica al progreso de las artes y las ciencias, presentada en su Discurso sobre las ciencias y las artes. Se presta atención especialmente a las peculiaridades retóricas de sus argumentos en su presentación de la naturaleza humana.