bluuebunny/crossref_metadata_2025 huggingface dataset:
Deep learning of longitudinal chest X-ray and clinical variables predicts duration on ventilator and mortality in COVID-19 patients
Authors: Duanmu Hongyi , Ren Thomas , Li Haifang , Mehta Neil , Singer Adam J , Levsky Jeffrey M , Lipton Michael L , Duong Tim Q
Published: July 2022

Objectives: To use deep learning of serial Portable chest x-ray (pCXR) and clinical variables to predict mortality and duration on invasive mechanical ventilation (IMV) for Coronavirus disease 2019 (COVID-19) patients. Methods: This is a retrospective study. Serial pCXR and serial clinical variables were analyzed for data from day 1, day 5, day 1-3, day 3-5, or day 1-5 on IMV (110 IMV survivors and 76 IMV non-survivors). The outcome variables were duration on IMV and mortality. With 5-fold cross validation, the performance of the proposed deep learning system was evaluated by receiver operating characteristic (ROC) analysis and correlation analysis. Results: Predictive models using 5-consecutive-day data outperformed those using 3 consecutive-day and 1-day data. Prediction using data closer to the outcome was generally better (i.e., day 5 data performed better than day 1 data, and day 3-5 data performed better than day 1-3 data). Prediction performance was generally better for the combined pCXR and non-imaging clinical data than either alone. The combined pCXR and non-imaging data of 5-consecutive days predicted mortality with an accuracy of 85±3.5% (95% confidence interval (CI)) and an area under the curve (AUC) of 0.87±0.05 (95% CI) and predicted the duration needed to be on IMV to within 2.56±0.21 (95% CI) days on the validation dataset. Conclusions: Deep learning of longitudinal pCXR and clinical data have the potential to accurately predict mortality and duration on IMV in COVID-19 patients. Longitudinal pCXR could have significant prognostic value if these findings can be validated in a large, multi-institutional cohort.
The impact of near-infrared autofluorescence on postoperative hypoparathyroidism during total thyroidectomy: a case-control study
Authors: Barbieri Diego , Indelicato Pietro , Vinciguerra Alessandro , Salerno Emilio , Battista Rosa Alessia , Marco Federico Di , Giordano Leone , Luce Francesca Lira , Bondi Stefano , Trimarchi Matteo , Bussi Mario
Published: July 2022

Purpose: Near-infrared autofluorescence is a new technology in thyroid surgery to better localize and preserve parathyroid glands. The purpose of this study is to assess if the adoption of NIR-AF can improve in short-, medium-, and long-term post-operative calcium and PTH levels compared to conventional “naked-eye” surgery in patients undergoing TT for benign or malignant conditions.Methods: 134 patients undergone total thyroidectomy between January 2020 and June 2022; 67 were treated with conventional thyroidectomy, the other 67 underwent surgery adopting an autofluorescence detecting device.Results: Significant differences were found between the two groups in percentage of patients with short-term hypocalcemia (p=0.04) and short-term hypoparathyroidism (p=0.011). Median short-term (p=0.01) and medium-term (p=0.03) PTH levels were significantly higher in autofluorescence group, while, short- (p= 0.001), medium- (p<0.001) and long-term (p=0.019) percentage variation of PTH levels from baseline were significantly higher in the standard-care group. Finally, the prescription of oral calcium (p <0.01) after surgery were significantly lower in the autofluorescence group.Conclusion: The adoption of near-infrared autofluorescence during total thyroidectomy is related to lower short-term hypocalcemia and hypoparathyroidism rates, decreased variation of post-operative PTH levels in short- and medium- and long-term, reducing the necessity of supplementation therapy with oral calcium compared to conventional surgery.
Child gender-related vulnerability and chronic malnutrition in Burkina Faso: the moderating role of the maternal education.
Authors: Sawadogo Pengdewendé Maurice , Kobiané Jean-François , Nguemeleu Eric Tchouaket , Sia Drissa , Onadja Yentéma
Published: July 2022

Background: Chronic malnutrition in children is a growth disorder resulting from a prolonged lack of nutrient intake. It is a widespread health issue in West and Central Africa where it affects one third (1/3) of children under five (05). This paper highlights the mitigation of child’s gender-based chronic malnutrition risk through maternal education. Methods: This paper uses data from the 2010 Demographic and Health Survey in Burkina Faso. Univariate and bivariate descriptive analysis techniques, multilevel logistic regression and interaction analyses were used. Analyses were conducted separately for children aged 0-5 months, 6-23 months and 24-59 months. Results: The results showed that boys are at greater risk of suffering from chronic malnutrition than girls, even after considering control factors. This gender-based effect was observed in children in the 6-23 month and 24–59-month age subgroups. Furthermore, the interaction analysis showed that this gender effect is more pronounced in and even specific to children of uneducated mothers because of the latter’s inappropriate hygiene and sanitation practices. Conclusion: These results suggest that intensifying policies to encourage girls’ schooling and strengthening hygiene and sanitation measures among children would reduce or even eliminate gender-based inequalities in chronic malnutrition among children in Burkina Faso.
MicroRNA-376b is involved in the pathogenesis and remission of Graves' disease by regulating HAS2
Authors: Liu Rongjiao , Ye Zhengqin , Liu Qi , Xuan Miao , Li Ran , Zhang Liya , Zhang Keqin , Fang Ping , Xue Ying
Published: July 2022

Background: Accumulating data suggest that microRNAs play important roles in the pathophysiology of Graves’ disease (GD). The aim of this study was to investigate the changes in the expression of miR-376b and its downstream target, hyaluronan synthase 2 (HAS2), in patients with GD, and the molecular mechanisms involved in the pathogenesis of GD. Methods: Initial GD patients, GD patients in remission and healthy controls were recruited from Shanghai Tongji Hospital. The expression changes of miR-376b and HAS2 in peripheral blood mononuclear cells (PBMCs) were detected among three groups. 6T-CEM cells were treated with T3, hsa-miR-376b mimics or hsa-miR-376b inhibitors, respectively. Cell proliferation was detected by CCK8, and cell apoptosis was assayed by TUNEL. In addition, the gene expression was analyzed by quantitative real time polymerase chain reaction (qPCR), and the protein expression was detected by Western blotting. Results: Compared with the healthy controls, the expression of miR-376b in PBMC of initial GD patients was significantly decreased, while the expression of HAS2 was significantly increased. Compared with initial GD patients, miR-376b expression in PBMC of GD patients in remission was remarkably increased, whereas HAS2 expression was dramatically decreased. MiR-376b expression in PBMC was dramatically negatively correlated with FT3 and FT4 levels, whereas HAS2 expression showed a significant positive relationship with FT3 and FT4. Furthermore, the expression of HAS2 in PBMC showed a significant negative correlation with miR-376b. After stimulation with T3, the expression of miR-376b in 6T-CEM cells was obviously reduced compared to the controls. MiR-376b mimics significantly decreased HAS2 protein expression and the mRNA expression of ICAM1 and TNF-α in 6T-CEM cells, while miR-376b inhibitors markedly elevated HAS2 protein expression and the gene expression of ICAM1 and TNF-α. We also found that miR-376b could inhibit apoptosis of 6T-CEM cells. Conclusions: The expression of miR-376b and HAS2 in PBMCs was significantly correlated with the levels of FT3 and FT4. T3 could regulate the expression of miR-376b, while miR-376b could modulate the expression of HAS2 and inflammatory factors and inhibit cell apoptosis. We speculate that miR-376b and HAS2 may be predictors of GD pathogenesis and possible therapeutic targets of GD.
Skin Lesion Classification of Dermoscopic Imagesusing Machine Learning and Convolutional Neural Network
Authors: Shetty Bhuvaneshwari , Fernandes Roshan , Rodrigues Anisha P , Lakshmanna Kuruva
Published: July 2022

Detecting dangerous illnesses connected to the skin organ, particularly malignancy, requires the identification of pigmentedskin lesions. If a patient with a pigmented lesion is diagnosed as having or at risk of getting skin cancer, immediate steps canbe done to reduce their risk or eliminate the malignancy if it is detected early. Dermoscopy and dermatologist are the mostpopular methods for diagnosing skin cancer. Image detection techniques and computer classification capabilities can boostskin cancer detection accuracy. The dataset used for this research work is based on the HAM10000 dataset which consists of10015 images. We have analyzed the classification accuracy of the Machine Learning algorithms and Convolutional NeuralNetwork models. We have concluded that Convolutional Neural Network provides better accuracy compared to other machinelearning algorithms implemented in the proposed work. Precision, Recall, and F1-Score were chosen as evaluation metrics,along with Accuracy. In the proposed system, as the highest, we obtained an accuracy of 95.18% with the CNN model. Thek-fold cross-validation method is used to validate the accuracy obtained by the Machine Learning algorithm. The proposedwork helps early identification of seven classes of skin disease and can be validated and treated appropriately by medicalpractitioners.
Anticipated Network Surveillance - An extrapolated study to predict cyber-attacks using Machine Learning and Data Analytics
Authors: Srivast Aviral , Thakkar Dhyan , Valiveti Sharda , Shah Pooja , Raval Gaurang
Published: July 2022

Machine learning and data mining techniques are utiized for enhancement of the security of any network. Researchers used machine learning for pattern detection, anomaly detection, dynamic policy setting, etc. The methods allow the program to learn from data and make decisions without human intervention, consuming a huge training period and computation power. This paper discusses a novel technique to predict an upcoming attack in a network based on several data parameters. The dataset is continuous in real-time implementation. The proposed model comprises dataset pre-processing, and training, followed by the testing phase. Based on the results of the testing phase, the best model is selected using which, event class which may lead to an attack is extracted. The event statistics are used for attack prediction. Implementation of the proposed architecture is evaluated against accuracy, precision, recall, and F1 score for processed data.
Transcutaneous CO₂ application combined with low-intensity pulsed ultrasound accelerates bone fracture healing in rats
Authors: Sawauchi Kenichi , Fukui Tomoaki , Oe Keisuke , Oda Takahiro , Yoshikawa Ryo , Takase Kyohei , Yamamoto Yuya , Inoue Shota , Matsushita Takehiko , Matsumoto Tomoyuki , Hayashi Shinya , Kuroda Ryosuke , Niikura Takahiro
Published: July 2022

Background
Low-intensity pulsed ultrasound (LIPUS) is a non-invasive therapy that accelerates fracture healing by promoting endochondral ossification, osteoblast differentiation, and angiogenesis. We recently reported that the transcutaneous application of CO2 using a hydrogel accelerated fracture healing in association with the promotion of angiogenesis, blood flow, and endochondral ossification. We hypothesized that transcutaneous CO₂ application, combined with LIPUS, would promote bone fracture healing more than the single treatment with either of them.
Methods
Femoral shaft fractures were produced using drop weight in twelve-week-old rats. Animals were randomly divided into four groups: the combination of CO2 and LIPUS, CO2, LIPUS, and control groups. After the CO2 absorption-enhancing hydrogel was applied, the limb was sealed in a CO2-filled bag for 20 min. LIPUS was applied for 20 minutes. At weeks 1, 2, 3, and 4 after the fractures, we assessed the bone union rate and fracture healing score using radiography. We histologically assessed the degree of fracture healing and evaluated gene expression by real-time PCR to assess chondrogenic differentiation, osteogenic differentiation, and angiogenesis at weeks 1, 2, 3, and 4. For the biomechanical assessment, a three-point bending test was performed at week 4.
Results
The fracture healing score using radiographs in the combination group was significantly higher than that in the control group at all time points and those in both the LIPUS and CO2 groups at weeks 1, 2, and 4. The degree of bone fracture healing in the histological assessment was significantly higher in the combination group than that in the control group at weeks 2, 3, and 4. In the gene expression assessment, significant upregulation of Runx2 and VEGF was detected in the combination group compared to the LIPUS and CO2 monotherapy groups. In the biomechanical assessment, the ultimate stress was significantly higher in the combination group than in the LIPUS and CO2 groups.
Conclusions
The combination therapy of transcutaneous CO2 application and LIPUS had a superior effect in promoting fracture healing through the promotion of angiogenesis and osteoblast differentiation compared to monotherapy. In clinical practice, combination therapy may be more beneficial to patients than monotherapy.
PAK5 is a potential target in myelodysplastic syndrome through interacting with LMO2 and GATA1
Authors: Pan Xiaoyan , Liu Dawei , Ying Minchao , Zheng Gaoming , Fan Chaoming , Pan Feng , Ke Qiang
Published: July 2022

Myelodysplastic syndrome (MDS) is a neoplastic heterogeneous and pre-leukemic disease with poor clinical outcome due to the failure of current chemotherapeutic strategies to target leukemic stem cells. Recently, we find that p21-activated kinase 5 (PAK5) overexpresses in MDS patients and leukemia cell lines. The clinical and prognostic value of PAK5 in MDS is unclear although it has anti-apoptosis ability and can promote cell survival and mobility in solid tumors. In this study, we find that LMO2 is co-expressed with PAK5 in the aberrant cells from MDS, and mitochondria-localized PAK5 can translocate into cell nucleus upon fetal bovine serum stimulation to interact with LMO2 and GATA1, which are important transcription regulators in hematological malignancies. Interestingly, without LMO2, PAK5 fails to bind GATA1 and facilitate GATA1 Ser161 site phosphorylation, indicating that PAK5 may be a key kinase in LMO2-associated hematopoietic diseases. Moreover, we find that PAK5 protein level in MDS is significantly higher than leukemia, and the data of 2095 leukemia samples from ‘BloodSpot’ database shows that PAK5 mRNA level in MDS is also increased obviously. Taken together, our findings suggest that PAK5-targeted strategies in clinical therapy have a potential value on MDS intervention.
Reproductive experiences of young women after breast cancer diagnosis: A qualitative study
Authors: Qiu Jiajia , Tang Lichen , Li Ping , Liu Guangyu , Rong Xinyi
Published: July 2022

Background: Breast cancer has the highest incidence rate among malignant tumors in China, with a trend of affecting younger women. The survival rate of young women with breast cancer has improved significantly, but the treatment to which they are subjected has short- and long-term adverse effects such as damage to the ovaries, which may result in infertility. Such consequences, in turn, increase patients’ concerns over future reproduction and childbearing. At present, patients lack easy access to the informative consultations and accurate patient education. Nor do medical staffs continuously assess their overall well-being, engage in mental healthinterventions, or ensure that they have the knowledge necessary to manage their reproductive concerns. This qualitative study aims to explore the reproductive and psychological experiences of young women with breast cancer who have experienced childbirth after their cancer diagnosis.Methods: A descriptive qualitative study with purposive sampling using audio‑recorded fact‑to‑face interviews was conducted. A total of 12 young women with breast cancer who experienced childbirth after cancer diagnosis participated in this study. Data collection was from September, 2021 to January, 2022 and content analysis method was used to analyze the data. Results: Five distinct themes emerged from the analyses:(1) multifaceted reproductive motivation, (2) multiple emotional experiences, (3) multi-dimensional support needs, (4) influencing factors on reproductive decision-making, and (5) outcome experience of reproductive decision-making. Conclusions: The reproductive decision-making process of young women with breast cancer was affected by many factors. Reproductive motivation came from many aspects. Patients had various emotional experiences in the whole reproductive process and face various difficulties in supporting their needs. Therefore, the reproductive needs of young women with breast cancer should be considered during the reproductive decision-making process, and their reproductive willingness should be recognized as dynamically changing. Professional support and peer support should be provided in the reproductive process to build an effective communication channel for reproductive decision-making, improve the decision-making ability, alleviate the negative emotional experience, and promote a smooth process of reproductive experience for young patients.
Effect and mechanism of electrical vagus nerve stimulation on ischemic stroke injury in mice by promoting vascular endothelial regeneration
Authors: Du Li , Xiong Xiaoxing , Sheng Huaxin , Sun Qian , Jian Zhihong , Yang Zhenxing
Published: July 2022

Objective: In this study vagus nerve stimulation (VNS) was used in mouse ischemic stroke model to observe its effects on the proliferation of vascular endothelial cells and gliogenesis, and to explore the potential protective mechanism of VNS on ischemic stroke angiogenesis. Methods: 80 male C57BL/6J mice were randomly divided into four groups: A: Sham+VNS group; B: pMCAO+VNS group; C: pMCAO +VNI group D: Sham group. The behavioral changes of mice were monitored after operation. Laser speckle Doppler imager was used to detect the cerebral blood flow and blood vessel density of mice at 6 hours, 3 days, 7 days and 14 days after operation. Evans Blue method was used to measure blood-brain barrier integrity, the ratio of dry and wet weight of brain tissue was measured to measure the degree of edema in the brain tissue of mice in each group, CD31/Ki67, GFAP/Ki67, and Ibal/Ki67 were identified by immunofluorescence method to label new vascular endothelial cells and new glial cells, The expressions of angiogenic factors such as endothelial nitric oxide synthase (eNOS), brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF) were detected by Elisa Kits.Results: 1. VNS treatment can effectively improve neurological deficit scores of the stroke mice after VNS treatment at 7 days, 14 days and 21 days (P<0.05); 2.Laser speckle Doppler imager showed that vascular density in pMCAO+VNS group was more obvious increased than in pMCAO+VNI group at every moment (P<0.05). 3.T Evans Blue method suggested that VNS could reduce the degree of damage to the blood-brain barrier after ischemic stroke (P<0.05) and also effectively reduce the degree of brain edema after pMCAO (P<0.05). 4. CD31/Ki67, GFAP/Ki67 and Ibal/Ki67 co-localize, suggesting that VNS can induce new blood vessels in the ischemic penumbra 5. VNS induce the up-regulation of BDNF, eNOS and VEGF protein expression in the ischemic penumbra of brain tissue after pMCAO (P<0.05).Conclusion: VNS can improve the nerve injury of ischemic stroke by regulating vascular endothelial cell regeneration and glial cell remodeling, and provide guidance for further exploration of stroke neuroprotection.
WITHDRAWN: Scale effects on the combustion characteristics and flame stability of a methane-air mixture in continuous flow reactors
Authors: Chen Junjie
Published: July 2022

A fundamental understanding of the stabilization mechanisms of a flame within very small spaces is of both fundamental and practical significance. This study relates to the scale effects on the combustion characteristics and flame stability of a methane-air mixture in continuous flow reactors. Computational fluid dynamics simulations are conducted to gain insights into reactor performance such as species concentrations, temperatures, and flames. The factors affecting combustion characteristics are determined for the continuous flow reactors. Particular focus is placed on determining essential factors that affect the performance of the continuous flow reactors. The results indicate that for large separation distances, the reaction rate is low and reaction spreads out over the burner due to slow heat transfer from the wall where ignition starts towards the centerline where un-combusted mixture exists. For smaller separation distances, reaction is more localized, with greater intensity, causing steeper temperature and composition gradients. When the separation distance is small, the transverse length scale of the fluid is small enough that the transverse heat transfer affects the centerline temperature, and thus, the maximum fluid temperature. In this case, the maximum fluid temperature is significantly lower than that for larger separations and incomplete conversion is observed. There appears to be an optimum plate separation that exhibits the shortest flame location. This distance permits the wall to preheat the inlet fluid fast enough, yet not to reduce significantly the centerline temperature. Burners with small plate-separation distances suffer from axial heat transfer through the walls of the burner, reducing the maximum fluid temperature and flame stability. Burners with large gaps slowly transport heat axially to preheat the feed, resulting in a late flame ignition and possible blowout.
A multi-country survey on the impact of COVID-19 on dental practice and dentists’ feelings in Latin America
Authors: Moraes Rafael R. , Cuevas-Suárez Carlos E. , Escalante-Otárola Wilfredo G. , Fernández María R. , Dávila-Sánchez Andrés , Grau-Grullon Patricia , Fernández Eduardo , López Tania M. , Grazioli Guillermo , Arana Luis A. , Rondón Luis F. , Torrez Willy B. , Lima Giana S. , Schuch Helena S. , Correa Marcos B. , Demarco Flavio F.
Published: July 2022

BackgroundThe COVID-19 pandemic has significantly influenced the routine of healthcare workers. This study investigated the impact of the pandemic on dental practice and dentists’ feelings in Latin America.Methods: A survey was conducted with dentists from 11 Spanish-speaking Latin American countries in September–December 2020. Professionals were invited by email and via an open campaign promoted on social media. The questions investigated dental care routines, practice changes, and feelings about the pandemic. Descriptive statistics were used to identify frequencies and distributions of variables. Proportions were compared using chi-square tests.ResultsA total of 2127 responses were collected from a sample with diverse demographic, sex, work, and education characteristics. The impact of COVID-19 was considered high/very high by 60% of respondents. The volume of patients assisted weekly was lower compared with the pre-pandemic period (mean reduction = 14 ± 15 patients). A high rate of fear to contracting the COVID-19 at work was observed (85%); 4.9% of participants had a positive COVID-19 test. The main professional challenges faced by respondents were reduction in the number of patients or financial gain (35%), fear of contracting COVID-19 (34%), and burden with or difficulty in purchasing new personal protective equipment (22%). The fear to contracting COVID-19 was influenced by the number of weekly appointments. A positive test by the dentists was associated with their reports of having assisted COVID-19 patients. The most cited feelings about the pandemic were uncertainty, fear, worry, anxiety, and stress. Negative feelings were more prevalent for professionals who did not receive training for COVID-19 preventive measures and those reporting higher levels of fear to contract the disease.ConclusionThis multi-country survey indicated a high impact of the pandemic on dental care routines in Latin America. A massive prevalence of bad feelings was associated with the pandemic.
Strawberry Cultivar Trials for Yield and Fruit Quality in Subtropical Southern Florida
Authors: Brym Maria , Fu Yuqing , Frade Noah , Baldwin Elizabeth , Chambers Alan H.
Published: July 2022

Strawberry (Fragaria ×ananassa) is grown during the winter months in subtropical southern Florida and must thrive in higher than average temperatures and limestone soils. This is the first strawberry cultivar trial in southern Florida to include ‘Florida Beauty’, ‘Florida Brilliance’, ‘Strawberry Festival’, ‘Florida Radiance’, ‘Sensation FL127’, and ‘Winterstar’. Overall, ‘Strawberry Festival’ and ‘Sensation FL127’ were the top yielding cultivars, with the highest average total yields of 0.7 and 0.8 kg/plant fresh fruit, respectively. ‘Sensation FL127’ had a 36% greater late-season marketable yield compared with ‘Strawberry Festival’. ‘Sensation FL127’ consistently had the greatest soluble solids content (7.6% to 8.7%). Overall, this study demonstrates significant differences in yield and fruit quality among the cultivars tested in southern Florida.
COMPETÊNCIAS GERENCIAIS DO ENFERMEIRO NO CENTRO CIRÚRGICO
Authors: Leoni Jr. Luis Carlos , Santos Alissandra Maria dos , Hornburg Eduarda Caroline Obenaus , Cembranel Priscila
Published: July 2022

A gestão do cuidado no centro cirúrgico preza pela qualidade da assistência e pelas boas condições de trabalho para os enfermeiros. Para isso acontecer adequadamente, os enfermeiros líderes dos centro cirúrgicos devem ter competências gerenciais para coordenar bem suas equipes de trabalho. Nesse contexto, esse estudo teve como objetivo geral descrever as competências gerenciais do enfermeiro no Centro Cirúrgico (doravante CC). Tratou-se de uma pesquisa qualitativa, exploratória, descritiva e de campo, a partir da análise de conteúdos conforme Minayo (2007), dos quais emergiram 5 categorias e suas respectivas subcategorias. Foram apresentadas as análises e discussões referentes as respostas de questionários aplicados junto aos enfermeiros do CC em um hospital situado ao norte do Estado Catarinense. Percebeu-se que os enfermeiros mantêm basicamente a mesma linha de pensamentos sobre as competências necessárias do gerenciador do CC são: dinamismo, versatilidade, planejamento, organização, liderança, controle e gestão do seu local de trabalho e conhecimento teórico e prático. Pode-se concluir pela pesquisa realizada que a atuação do enfermeiro dentro do CC, através de competências que lhe permitam gerenciar sua equipe na prestação de cuidados é de suma relevância na busca de uma gestão qualificada para se obter resultados benéficos no atendimento direto ao paciente.
SAÚDE 4.0: APLICAÇÃO DOS CONCEITOS DA INDÚSTRIA 4.0 NO SETOR DE SAÚDE
Authors: Sousa Josiano
Published: July 2022

RESUMO: Os conceitos da indústria 4.0 surgiram em 2011 na Alemanha e, desde então, vêm despertando interesse de pesquisa em todo o mundo. No entanto, muitos dos conceitos da Indústria 4.0 apresentam uma abordagem direcionada apenas ao setor de manufatura, ignorando sua aplicação ao setor de serviços. Com o objetivo de identificar como os conceitos da indústria 4.0 podem afetar o setor de serviços de saúde, o presente artigo foi elaborado através de uma revisão bibliométrica, realizada a partir de 347 artigos da base de dados Scopus. Como principais resultados, foram elaboradas tabelas e mapas conceituais com utilização dos softwares Atlas TI e VOSviewer, que permitem visualizar os principais países, autores e palavras chaves das publicações encontradas. Constatou-se ainda que o advento da indústria 4.0 introduziu a aplicação de conceitos como: Internet das Coisas, Big Data, Computação em Nuvem, Sistemas Ciber Físicos, Digitalização, Trabalho Inteligente, Customização em Massa e Automação de Processos e que estes conceitos também estão presentes no setor de serviços e são perfeitamente aplicáveis ao setor de saúde. Ao final, o artigo apresenta suas limitações e as contribuições acadêmicas e gerenciais.
Palavras chave: Gestão da Inovação, Indústria 4.0, Setor de Saúde.
The Effects of Moisture Content on the Temperature of Some Selected Soil Samples in the Presence of Internal Heat
Authors: Ogunsola Amos Wale , Olaleye Olalekan Ayodeji , Olalude Gbenga Adelekan
Published: July 2022

The effect of moisture content on the temperature of some selected soil samples in the presence of internal heat was studied. The governing equation was modeled using Bosenneque’s approximation base on some necessary assumptions by which the transfer occurred. These equations were non-dimensionalized by employing some standard dimensionless parameters and later reduced to ordinary differential equations using perturbation method. This was then solved analytically. The various effects of the physical parameters that materialized were examined on the unsaturated and saturated forms of some selected soil samples. With the aid of Matlab software, the numerical results were graphed for visual examination. It was observed that the presence of moisture content in these soils helped in boosting their temperatures as the solar radiation and internal heat increase.
Quantum to classical mapping of the two-dimensional toric code in an external field
Authors: Timmerman Sydney R. , Bandic Zvonimir , Melko Roger
Published: July 2022

Kitaev's toric code Hamiltonian in dimension D=2 has been extensively studied for its topological properties, including its quantum error correction capabilities.
While the Hamiltonian is quantum, it lies within the class of models that admits a D+1-dimensional classical representation.
In these notes, we provide details of a Suzuki-Trotter expansion of the partition function of the toric code Hamiltonian in the presence of
an external magnetic field.
By coupling additional degrees of freedom in the form of a matter field that can subsequently be gauged away,
we explicitly derive a classical Hamiltonian on a cubic lattice which takes the form of a non-isotropic
3D Ising gauge theory.
Daily Sea Water Temperature Forecasting Using Machine Learning Approaches
Authors: ÖZBEK Arif
Published: July 2022

The efficiency of turbines in seaside nuclear or coal-fired power plants is directly proportional to sea water temperature (SWT). The cooling medium temperature is critical in the design of any power plant when considering long-term average climatic conditions. As a result, the deviation in the SWT affects the efficiency of electricity generation. Accurate SWT estimation is critical for electrical output from power plant applications in this regard. Three different data-driven models such as long short-term memory (LSTM) neural network, adaptive neuro-fuzzy inference system (ANFIS) with fuzzy c-means (FCM) and grid partition (GP) were used to perform one-day ahead short-term SWT prediction, in this paper. The analyses were performed using 5-year daily mean SWTs measured by the Turkish State Meteorological Service in Canakkale Province between 2014 and 2018. The measured data was also used to validate the data produced by the proposed techniques. Performance criteria for the techniques suggested are mean absolute error (MAE), root mean square error (RMSE) and correlation coefficient (R). With the ANFIS-FCM technique, the best outcomes for MAE, RMSE and R values were obtained as 0.113oC, 0.191oC, and 0.9994, respectively, according to daily SWT forecasting.
Euler Bernoulli ve Timoshenko Kiriş Teorilerine Dayalı Eksenel Yönde Fonksiyonel Derecelenmiş Kolonların Burkulma Analizi
Authors: SİVRİ Burkay , TEMEL Beytullah
Published: July 2022

Bu çalışmada; eksenel yönde fonksiyonel derecelenmiş malzemeli, doğru eksenli kolonların burkulma yükü Tamamlayıcı Fonksiyonlar Yöntemi (TFY) ile incelenmiştir. Burkulma davranışını idare eden birinci mertebeden kanonik denklemler, Euler-Bernoulli (BKT) ve Timoshenko kiriş teorilerine (TKT) dayalı olarak denge denklemleri yardımıyla elde edilmiştir. Adi diferansiyel denklem takımları, Python dilinde hazırlanan programla çözülmüştür. Malzeme değişim fonksiyonunun, uzunluk/kalınlık oranının ve farklı sınır koşullarının burkulma yüküne etkisi parametrik olarak araştırılmıştır. Elde edilen burkulma yükleri, literatürde bulunan mevcut yöntemler ve Abaqus sonlu elemanlar programında bulunan değerler ile karşılaştırılmış, uygulanan yöntemin etkinliği gösterilmiştir.
Application of laterite soil in removing chloride ion from drinking water
Authors: Mita Ayesha Ferdous , Ekra Nusrat Jahan , Banik Bijit Kumar , Hoque Muhammad Azizul , Kabir Md. Imran
Published: July 2022

Increasing salinity is a crucial issue for the people of coastal regions in Bangladesh. To resolve this problem, efficient and low-cost materials can be used as adsorbents to remove salinity from water. Among those, laterite soil (LS) is one of the efficient adsorbents in water treatment. This study demonstrates a low-cost salinity removal technique using laterite soil as adsorbent. The effect of burning temperature on raw laterite and synthetic laterite has been analyzed. The performance of the adsorbents has been observed in terms of efficiency in salinity removal. Both batch and column adsorption have been carried out to evaluate the adsorption capacity of raw LS and burned LS, respectively. Raw laterite shows maximum adsorption capacity of 21.24 mg/g in batch adsorption at an initial concentration of 900 mg/L. The optimum burning temperature for thermally treated LS has been found as 600 °C. However, SLS (Synthetic Laterite Soil) burned at 600 °C gives greater chloride ion removal efficiency (44.54%) than LS (38.23%) in removing salinity from water.
Serum Levels of ARMS2, COL8A1, RAD51B, and VEGF and their Correlations in Age-related Macular Degeneration
Authors: Battu Priya , Sharma Kaushal , Rain Manjari , Singh Ramandeep , Anand Akshay
Published: July 2022

Background:

Many factors including genetic and environmental are responsible for the
incidence of Age-related Macular Degeneration (AMD). However, its pathogenesis has not been
clearly elucidated yet.

Objective:

This study aimed to estimate the Age-Related Maculopathy Susceptibility 2 (ARMS2),
Collagen type VIII Alpha 1 chain (COL8A1), Rad 51 paralog(RAD51B), and Vascular Endothelial
Growth Factor (VEGF) protein levels in serum of AMD and control participants and to further investigate
their correlation to understand AMD pathogenesis.

Methods:

For this case-control study, 31 healthy control and 57 AMD patients were recruited from
Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
A blood sample was taken and serum was isolated from it. ELISA (enzyme-linked immunosorbent
assay) was used for the estimation of proteins in the serum of patients.

Results:

ARMS2 and COL8A1 levels were significantly elevated in the AMD group than in the
control group. The highest levels of ARMS2, COL8A1, and VEGF proteins were recorded for the
wet AMD sub-group. The study results endorsed significant positive correlation between these following
molecules; ARMS2 and COL8A1 (r = 0.933, p < 0.0001), ARMS2 and RAD51B (r =
0.704, p < 0.0001), ARMS2 and VEGF (r = 0.925, p < 0.0001), COL8A1 and RAD51B (r = 0.736,
p < 0.0001), COL8A1 and VEGF (r = 0.879, p < 0.0001), and RAD51B and VEGF (r = 0.691,
p < 0.0001).

Conclusion:

The ARMS2 and COL8A1 levels were significantly higher and RAD51B was significantly
lower in the AMD group than controls. Also, a significant statistical correlation was detected
between these molecules, indicating that their interaction may be involved in the pathogenesis
of AMD.
Cutaneous Anthrax in a Farmer Man: A Case Report
Authors: Mahmoudi Hassan
Published: July 2022

Introduction:

Anthrax is an acute infection caused by Bacillus anthracis, an anaerobic, spore-forming, Gram-positive bacterium. Anthrax disease is a common disease among herbivores and humans that is transmitted to humans through direct contact with farm animals that are sick or have died of anthrax.

Case Summary:

A 43-year-old man having livestock as a profession had a cutaneous anthrax infection on the dorsal surface of his left thumb. The patient was infected with anthrax by slaughtering a sheep infected with Bacillus anthracis. He was treated with penicillin after an early diagnosis of anthrax bacillus.

Conclusion:

Anthrax infection is a highly contagious disease, and early detection is very important. There is a need to strengthen the health care system for farm animals and educate farmers on how not to consume the meat of diseased carcasses and how to dispose them of hygienically, especially in high-risk areas.
Six Dominant Decision-making Algorithms
Authors: Rodgers Waymond
Published: July 2022

Algorithms have been implemented to benefit decision-making for hundreds of years
and pre-date computers. While algorithms are hardly a contemporary invention, they
are nonetheless progressively intricate in systems implemented to support decision.making. Algorithmic decision-making is the processing of input data or perceptual
processing to influence a judgment or decision choice. Further, algorithms are utilized
to support decisions such as prioritization, classification, association, and filtering. This
chapter illustrates a broad introduction to six fundamental algorithms for decision
making. These algorithms in total make up the Throughput Model. Each algorithm is
clearly presented and can comprehensively assist individuals and organizations in
considering a wide range of issues. 
The Revisionist Algorithmic Pathway
Authors: Rodgers Waymond
Published: July 2022

The Revisionist Algorithmic Pathway (I→P→D) focusses on an unstructured
environment whereby people or organizations may use all available information to
influence their perception before rendering a decision. In this situation, the information
can be complete or incomplete. Nonetheless, due to the vagueness of the event it
becomes challenging for individuals or organizations to model the data according to
rating, ranking, or ordering. Hence, the use of this algorithmic pathway is highly
dependent on information changing resulting in a alteration of how individuals or
organizations perceive a situation.
Literair Kwartier. De radio as spegel en megafoan fan ’e Fryske literatuer tusken 1945 en 1975
Authors: Kingma M. , Jensma G.T.
Published: July 2022

This contribution entails an extensive analysis of the Northern Dutch literary radio program Literair Kwartier (Literary Quarter). After Dutch national radio had already broadcasted literary programs from the early 1940s onward, the three Northern Dutch provinces (Fryslân, Groningen and Drenthe) were to follow as soon as they acquired a regional broadcasting station of their own in 1945, called RON or RONO. The emphasis on culture characterizing policy-making in postwar Dutch politics in general proved favorable to literature. In a great many book reviews and talks on literature Literair Kwartier acquainted literary critics and writers from the region to the broader listening audience. Since the program largely discussed Frisian literature, it makes for a remarkable insight into the issues, reception and evolution of this minority literature in the decades shortly after the Second World War. Yet, not in the least through the inclusion of book reviews of renowned national and international authors, Literair Kwartier also guided its listeners towards a proper high-brow literary taste. Literair Kwartier, the authors conclude, can best be seen not only as complementary to the written criticism of the period but also as an amplifier of the literary taste in the region in general.
Coleópteros Scarabaeoidea (Insecta: Coleoptera) de Aguascalientes, México
Authors: Márquez Juan , Reyes-Hernández José L. , Cerón-Gómez Rafael , Escoto-Moreno Jaime Antonio , Ramírez-Ponce Andrés
Published: July 2022

En México, los coleópteros Scarabaeoidea se conocen comúnmente como “escarabajos de mayo”, “escarabajos de junio” o “escarabajos sanjuaneros” y en el estado de Aguascalientes, México, es bajo su grado de conocimiento debido a la falta de especialistas en el grupo en esa entidad y a la falta de interés por parte de especialistas de otras instituciones fuera de Aguascalientes. Por lo anterior, esta contribución tiene como finalidad actualizar la riqueza específica de Scarabaeoidea y compararla entre municipios, tipos de vegetación, provincias biogeográficas y áreas naturales protegidas, además de compararla con la riqueza conocida en otros estados del país. Para ello, se hizo una revisión exhaustiva de registros de escarabajos en la literatura, en dos colecciones entomológicas nacionales y mediante recolectas ocasionales en algunos sitios del estado. Se registraron 105 especies de escarabajos, de las cuales 36 son primeros registros estatales y una especie nueva de Phyllophaga que aún no se describe. Aun cuando la aportación es relevante en el número de especies, es posible que falte registrar algunas especies en la entidad debido a la carencia de muestreos sistematizados, los pocos registros en selva baja caducifolia y matorral xerófilo, el reducido número de localidades con registros de escarabajos y el hecho de que el mayor número de especies se haya presentado en áreas urbanas, entre otros factores. La actual riqueza de especies del estado es alta en comparación con algunos estados de extensión territorial y condiciones climáticas similares, con excepción de Morelos, e incluso comparada con algunos estados más extensos que Aguascalientes del norte y centro del país. El 50 % de las especies se localizan en tres áreas naturales protegidas del estado, destacando la “Sierra Fría” y la Estación Biológica “Agua Zarca”, donde se promueve el estudio y la conservación de la biodiversidad.
Extracción selectiva de chicahuastle: efectos, conocimiento local y lineamientos de manejo
Authors: Palacios-Wassenaar Olivia M. , Castillo-Campos Gonzalo , Vázquez-Torres Mario , Wojtarowski Astrid
Published: July 2022

El chicahuastle (Stenostomum aromaticum) es un árbol endémico de la selva mediana subcaducifolia en el centro de Veracruz, México, en peligro de extinción debido a su distribución restringida, uso maderable y destrucción de su hábitat. Se evaluó el efecto de la extracción selectiva sobre el diámetro y altura de los individuos y la densidad de las poblaciones, así como la percepción de los pobladores locales sobre la especie, para proponer lineamientos de manejo. Se evaluaron los individuos de S. aromaticum y su densidad de población en cinco sitios con presencia de esta especie; y se realizaron encuestas y entrevistas semiestructuradas a pobladores en Jalcomulco, Veracruz. La extracción consiste en cortar ramas de tamaño específico; este procedimiento no genera alteración evidente sobre el diámetro, pero sí sobre la altura de los individuos. Su elevada capacidad de rebrote y su persistencia en fragmentos de vegetación primaria conservados han contribuido a la supervivencia de esta especie. Se concluye que la extracción selectiva afecta el desarrollo vertical de la especie, con posibles efectos adversos para la supervivencia de la especie a largo plazo, y que la densidad de la población se ha reducido. El conocimiento sobre esta especie se concentra en los ejidatarios de mayor edad, mientras que los jóvenes desconocen su existencia y usos, por lo que estos saberes están en riesgo de perderse si no se promueve su divulgación. La propuesta de crear una reserva y el manejo comunitario de la especie son las medidas más aceptadas entre los pobladores locales para su conservación.
Структурные и оптические свойства двумерных слоев Si и Ge, полученных методом молекулярно-лучевой эпитаксии на подложках CаF-=SUB=-2-=/SUB=-/Si(111)
Authors: Зиновьев В.А. , Дерябин А.С. , Кацюба А.В. , Володин В.А. , Зиновьева А.Ф. , Черкова С.Г. , Смагина Ж.В. , Двуреченский А.В. , Крупин А.Ю. , Бородавченко О.М. , Живулько В.Д. , Мудрый А.В.
Published: July 2022

Approaches to the formation of epitaxial structures containing two-dimensional Si and Ge layers embedded in a CaF2 dielectric matrix have been developed. Raman study demonstrates the presence of narrow peaks related to Si-Si and Ge-Ge bond vibrations in the growth plane of structure. In the photoluminescence spectra of the created structures, emission bands, which can be associated with the radiative recombination of charge carriers in two-dimensional Si and Ge layers embedded in CaF2 have been found.
Устойчивость к электронному облучению высоковольтных 4H-SiC диодов Шоттки в рабочем диапазоне температур
Authors: Лебедев А.А. , Козловский В.В. , Левинштейн М.Е. , Малевский Д.А. , Кузьмин Р.А.
Published: July 2022

Впервые исследовано влияние облучения электронами с энергией 0.9 МэВ на параметры 4H-SiC диодов Шоттки с предельным блокирующим напряжением Ub=600 и 1700 В в диапазоне рабочих температур Ti (23 и 175oС). Диапазон флюенсов Phi составлял 1·1016-2·1016 см-2 для приборов c Ub=600 В и 5·1015-1.5·1016 cм-2 для приборов c Ub=1700 В. Облучение при комнатной температуре значительно увеличивает дифференциальное сопротивление базы диодов. Облучение теми же дозами при Ti=175oС --- предельной рабочей температуре приборов практически не сказывается на параметрах вольтамперных характеристик. Тем не менее DLTS-спектры демонстрируют значительное увеличение концентрации глубоких уровней в верхней половине запрещенной зоны не только после облучения при комнатной температуре, но и после облучения при Ti=175oС. Ключевые слова: карбид кремния, диоды Шоттки, электронное облучение, вольт-амперные характеристики, DLTS-спектры.
Variation and Imperfection Their Implications to the Concept of Language
Authors: Kareem Rebeen Abdullah
Published: July 2022

The many various definitions of the term ‘language’ make it improbable to account for the nature of the variations within the languages of the world. It seems that the recent and dominant concept of language has certain shortfalls with regard to the accountability and definitions of variations. By giving a different account of certain parameters and by arguing that the human language should be seen as a system of thought having only syntactic and semantic properties, the cross-linguistic variations are considered as various morpho-phonological systems of the many languages of the world, which ought not to be considered as part of the generative language computation. Such arguments will have significant implications to the understanding and definitions of the concept of language. The findings indicate that, if the goal of the linguistic theory is to seek a perfect system and to minimize variations within and across the languages, the term ‘language’ should be seen as a single, natural, universal, and invariant system without assuming that its computation is a double-interface. In such an understanding, the ‘one’ human language should be perceived as a system of thought which has only syntactic and semantic properties; whereas the ‘many’ languages of the world are considered to be the conventional morpho-phonological systems that should not be part of the generative language computation.