bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of the clinical use and impact of Miao medicine's anti influenza mask on IgA in human serum and SIgA in nasal mucosa
Authors: Wang Menglong , Xiao Yang , Wang Zhiqiong , Gan Lin , Zhou Xixi , Zeng Yiju
Published: January 2024

Purpose: To investigate the clinical use of anti-influenza mask of Miao medicine, and its effect on human serum immunoglobulin A (IgA) as well as nasal mucosa secretory immunoglobulin A (SIgA).

Methods: 500 patients without COVID-19 in QianDongNanZhou Hospital of Traditional Chinese Medicine from January 2020 to September 2022 were selected and randomly divided into study and control groups, with 250 patients in each group. Both groups wore masks for three months. Control group was given disposable medical surgical three-layer melt-blown non-woven masks, while study group was given Miao medicine anti-infection masks. Serum IgA and SIgA levels were compared before and after wearing masks in both groups.

Results: Prior to intervention, serum IgA and SIgA levels in nasal mucosa were not significantly different (p > 0.05). There were also no significant differences in blood IgA levels between control and study groups. Before wearing masks, the study group had higher levels of blood IgA and nasal mucosal SIgA than control group. After wearing masks, nasal mucosa SIgA antibody levels and blood IgA antibody levels were significantly higher in the study group compared to control group (p < 0.001). The frequency of adverse responses did not significantly differ between the two groups (p > 0.05).

Conclusion: Miao medicine anti-infection masks are safe and raise serum levels of COVID-19 IgA antibodies and nasal mucosa SIgA levels in populations susceptible to COVID-19. These properties need to be compared among different races for the purpose of validation
Hypoglycemic and glucose lowering properties of Cordyceps militaris
Authors: Nguyen Phuong Dong Tran , Truong Nguyen Binh , Lao Thuan Duc
Published: January 2024

Diabetes mellitus is a serious endocrine disease characterized by hyperglycemia. This disease has been regarded as a major global health issue. Although majority of the current therapeutic approaches are beneficial in treating diabetes, there are still unfavorable side effects. The Chinese traditional medicinal fungi, Cordyceps militaris, has been used in the treatment of diabetes mellitus for centuries. This study summarizes the chemical compounds in Cordyceps militaris and their corresponding hypoglycemic effect in the development of therapeutic agents for diabetes mellitus based on recent reports. Several studies using chemically induced diabetic rats and mice models have established the antidiabetic effect of Cordyceps militaris administered at various doses. This report reveals that Cordyceps militaris has a great deal of promise and should be taken into consideration for the development of novel antidiabetic therapies.
Gefitinib enhances healing of long bone fractures in rats via inhibition of the epidermal growth factor receptor signal pathway
Authors: Shen Aofei , Wang Mengwei , Li Xiangheng
Published: January 2024

Purpose: To investigate the influence of gefitinib on healing of long bone fractures in rats, and the involvement of epidermal growth factor receptor (EGFR) signal route in the process.

Methods: A model of long bone fracture was established in 30 Sprague-Dawley (SD) rats which were allocated to control and study groups (n = 15/group). Rats in study group received gefitinib (100 mg/kg per day) via gavage, while control rats were given 0.55 % methylcellulose daily for 7 - 42 days. Fracture healing, maximum callus diameter, serum levels of bone markers and mRNA levels of bone turnover indices in the callus, were determined.

Results: Following 1 week of therapy, fracture lines were clear in both groups, and callus was produced. On days 7, 14, 21, and 28, maximum callus diameter of study group was significantly higher than that of control group (p < 0.05). However, there was no significant difference in the maximum callus diameter between the two groups after 42 days (p > 0.05). On days 7, 14 and 21, there were significantly higher BALP and PINP levels, and TRACP-5b and CTX values in study group than in control (p < 0.05). On days 7 and 14, study group COLa1 mRNA and osteocalcin (OC) mRNA was significantly raised, relative to control values. On days 7, 14 and 21, COL10 mRNA expression was significantly up-regulated in study group relative to controls (p < 0.05). However, mRNA expression levels of COLa1, OC, COL10, and COL2A1 were similar in both groups at other time points.

Conclusion: Gefitinib enhances the healing of long bone fractures and callus formation in rats, probably through inhibition of EGFR signaling pathway. Therefore, gefitinib is beneficial in bone formation in rats.
Przypadkowa kolekcja starożytności. Muzeum Narodowew Krakowie i jego darczyńcy
Authors: Gorzelany-Nowak Dorota
Published: January 2024

The information on collectors responsible for the museum collections is dominated by those who have donated the largest number of or the most spectacular works of art. The collection of ancient art in the National Museum in Krakow (MNK) is mostly known for the museum pieces from the Princes Czartoryski Museum, which had been established by Prince Władysław Czartoryski in 1876, three years before the National Museum in Krakow was opened. It overshadows the collections of the National Museum in Krakow, which were created accidentally thanks to numerous people who, for personal reasons, often wished to donate or sell sometimes just one or several ancient items to this institution. The article aims at commemorating several people and discussing modest gifts, ones that were the basis for creating the collection of the MNK ancient art after having been collected for several dozen years. These museum pieces, although they are not the most representative ones of a given culture, are a significant testament to the development of craft that completes Władysław Czartoryski’s collection and the permanent exhibition in the MNK’s Arsenal.
Perspektywy muzycznej semiotyki metalu ‒ w stronę interpretacji muzematycznej
Authors: Mądro Andrzej
Published: January 2024

The article is an overview of the most important concepts in the field of musical semiotics, and at the same time an indication of which of them have potential in relation to the study of metal music. Particular attention was paid to the method of musematic analysis, consistently used and developed for almost half a century by Philip Tagg, but also appreciated and practiced by other researchers.

The starting point for the author is the state of research in the field of “metal musicology” and theory of music ‒ there is still no adequate, new methodology, and at the same time a common space and a thread of understanding between disciplines and methodologies. Such an interdisciplinary perspective can be semiotics, especially musical, which is a valuable alternative and supplement to sociological, literary and cultural studies, etc. It has potential both where music is a (subordinate) medium of the message and a “amplifier” of the text, and where, through its structure and dramaturgy expresses “itself” in a way, constituting an abstract play of sounds and timbres.
Covery – manifesty. Muzyczne strategie przezwyciężania kulturowej opresji
Authors: Juszczyk Andrzej
Published: January 2024

In this article, I would like to focus on covers that reveal their strongly transgressive function, forcing the recipient to rethink and reinterpret the canon of popular music. Covers that I analyze in terms of music, text, image, etc., although they formally “reverse” only one specific song, become an opportunity to polemicize with the output of a given artist, the entire genre or style, or finally with the attitude and worldview represented by the original. Transgression on the aesthetic level is also accompanied by transgression on the level of sexual, class or racial identity. For the purposes of the article, the material will be limited to the covers from the 1970s (Ramblin’ Rose by Jerry Lee Lewis / MC5, Love Is Strange by Mickey & Sylvia / Trash by New York Dolls, Helter Skelter by The Beatles / Siouxsie and the Banshees), because in this period (on the basis of punk and post-punk music) similar practices were the most intense.
Pojawienie się bluesa w Polsce. Przypadek inwersji w ewolucji gatunku muzycznego
Authors: Kwieciński Wojciech
Published: January 2024

The emergence of blues from the aesthetics of the so-called “big-beat” in Polish popular music is a process that largely coincides with a parallel phenomenon observed in other European countries. With the expansion of rock and roll in the UK during the 1960s, many beat performers (e.g. The Rolling Stones, The Animals) turned towards blues aesthetics, attempting to imitate black American performers. It should be emphasised that this was done in isolation from the cultural context and “root” performance tradition and was a kind of experiment that, despite some cases of apparent stylistic deviation from the blues genre, brought many positive results, such as the emergence of the blues-rock subgenre or the penetration of blues elements into hard rock and progressive rock. The article’s title uses the term “inversion”, reflecting the reversed order of genre evolution. In Europe, blues did not imply the development of jazz or rock and roll, but through these genres, musicians and listeners became interested in the blues form and used its elements to transform the beat style into rock, eventually developing traditional blues performance. This article attempts to reconstruct the process of adapting blues in Poland and transforming the beat into a blues-rock style. The analysed phenomena’ chronological framework reaches back to jazz’s beginnings in the interwar period, while the clear boundary marking the emergence of blues-rock and its emancipation is the release of Breakout’s Blues album in February 1971.
Nie tylko folkowa osobność Berta Janscha
Authors: Dorobek Andrzej
Published: January 2024

In this text, we attempt, probably for the first time in Poland, at the synthetic presentation of the artistic achievements and not only creative personality of Bert Jansch, sometimes referred to as “British Dylan” and highly appreciated by fellow folk musicians as well as by genuine rock stars, such as Jimmy Page or Neil Young. Jansch’s career as a truly unique folk singer/guitar player/composer/lyric writer shall be dicussed here in a wider analytical perspective, with vital references to the history of the British and American folk movement as well as, first of all, to the career of his transatlantic “counterpart”. Jansch’s inability to comfortably fit into any folk or folk-rock stereotypes with respect to music, lyrics or media personality shall also be stressed, in the same comparative context.
Muzyczność w Innych ludziach Doroty Masłowskiej
Authors: Regiewicz Paweł
Published: January 2024

In this text I interpret the novel by the author of Wojna polsko-ruska pod flagą biało-czerwoną with special attention to the musicality present in it. Using the concept of Andrzej Hejmej, I analyze the stylistic tropes present in the novel (instrumentation, alliteration), musical references and transpositions of musical forms (aria, sonata, counaterpoint), considering what functions they perform in the novel. I pay special attention to indirect and direct references to hip-hop culture appearing in Maslowska’s book (e.g. rhythmic and rhyming narrative flow, onomatopoeias, vocal instrumentation). I show how the elements of musicality present in the novel influence its shape.
Development of Problem-Based Learning Model Physics Learning Tools to Improve Critical Thinking Skills of High School Students
Authors: Hidayati Arini , Munasir Munasir , Sudibyo Elok
Published: January 2024

Objective: Most EFL students need help to develop their speaking abilities. Due to their limited vocabulary, poor grammar, and lack of confidence, they could not practice speaking. Ten students from the English Department joined a study group to address these obstacles. Method: The procedure was carried out online. The teacher created a WhatsApp group as the initial class medium. He added to the vocabulary development and grammar education on the screen. The students studied the material on a video podcast to retell to meet the comprehension criteria, synchronizing their inputs with real life. They then describe a picture to hone their communication skills. They also transcript their story in order to make the spoken and written versions of it coincide. Results: After following the teacher's instructions to build sentences using the lexico-grammar technique, students can identify the grammatical conventions used in podcasts. They can adequately narrate pictures thanks to this type of learning. Their increased confidence fosters mature dialogue. The students' delivery will become more fluid due to the novelty of learning sentence construction through lexico-grammatical techniques and synchronizing it to podcast material. They acquired the ability to apply vocabulary and grammar norms contextually. It was evident from the way they described the images. To fit the needs of their students in the classroom, teachers might change them. It also encourages other researchers to continue their observations.
PODOSPHAERA XANTHII: AN UPDATE ON THE POWDERY MILDEW OF TROPICAL PUMPKIN (CUCURBITA MOSCHATA DUCHESNE) IN PUERTO RICO
Authors: Landrón-García Andrea , Linares-Ramírez Angela , Feliciano-Rivera Merari , Miranda-Cortés Yanira
Published: January 2024

PODOSPHAERA XANTHII: AN UPDATE ON THE POWDERY MILDEW OF TROPICAL PUMPKIN (CUCURBITA MOSCHATA DUCHESNE) IN PUERTO RICO
Dominando los números. Guía completa de matemáticas básicas
Authors: Quilumbaquin Imbaquingo Ángel Reimundo , Páez Padilla Mónica Elizabeth , Aulestia Rueda Romel Alejandro , Gaón Rojas Nancy Maricela
Published: January 2024

Este libro de matemáticas está diseñado para estudiantes de administración, cubriendo conceptos básicos y avanzados. Desde teoría de conjuntos y lógica matemática hasta derivadas y productos notables, el texto se enfoca en temas relevantes para contextos empresariales, como funciones polinomiales y exponenciales, inecuaciones y técnicas de factorización. También presenta herramientas avanzadas como matrices y el Método de Gauss-Jordán. Cada concepto se ilustra con ejemplos y gráficas, y los ejercicios refuerzan la comprensión. Este libro proporciona una base sólida en matemáticas para abordar desafíos cuantitativos en el mundo empresarial.
ULOGA SVEŠTENOSLUŽITELjA U JAVNIM USTANOVAMA REPUBLIKE SRBIJE
Authors:   University of Kragujevac, Faculty of Law, Matić Branislav
Published: January 2024

This paper examines the position of religion in certain public institutions of the Republic of Serbia. The work primarily focuses on education, military service, hospital and prison services. Special emphasis is placed on the importance of religious freedom in the context of these institutions, as well as on the importance of ensuring an adequate position for clergy in order to provide the best support to users. The paper will analyze the position of religion throughout history and in modern society and its contribution to the spiritual and emotional well-being of individuals in specific environments, providing them with support and comfort in difficult times. Through the analysis of these institutions, the paper highlights how cooperation between the state and the Church can contribute to the spiritual and emotional well-being of the citizens of the Republic of Serbia.
DEHRISTIJANIZACIJA: TEMELJ SUMRAKA ZAPADA
Authors:   Faculty of Political Sciences, University of Banja Luka, Bosnia and Herzegovina, Trifković Srđa
Published: January 2024

Exactly one hundred years have passed since the publication of the final edition of Oswald Spengler’s Twilight of the West. His gloomy predictions are coming true in a bizarre and even monstrous manner. The accelerated pace of the postmodern twilight requires the use of not so long ago completely unknown terms, such as “transgenderism,” “critical race theory,” “intersectionality,” “white privilege” etc., not to mention the ever-growing number of letters associated with the LGBTQ+ cult. We are witnessing a civilizational and moral decline unprecedented in history. The current twilight of the West has numerous secondary manifestations, such as the celebration of deviance as a laudable “lifestyle,” the imposition of multiculturalism and unrestricted immigration from the Third World, the demonization of the white, heterosexual male as the source of the so-called toxic muscularity etc. This article aims to penetrate the roots of the post-postmodern, increasingly posthuman ideological foundation of the West-as-ideology. It is found in de-Christianization, which began in Italy in the late Renaissance, received its mature form in the French Enlightenment, and today has a chthonic, distinctly thanatological character. Euro-globalist and American-hegemonic forms of madness are only apparently different. They share the same hatred towards traditional, spontaneously emerging societies and cultures. The differences between the two models of Sunovrat are not in the different concepts of global political and ideological monism, but above all in the pace and the means of implementing the cultural and moral revolution.
Doctor's Legal Responsibility in Telemedicine Services
Authors: Sanusi Sanusi , Rediyano Rediyano , Wulan Endah Ratna , Qomarddin Muhammad
Published: January 2024

Religion has been linked to mental health over the years, but its connection to persecutory ideation remains unclear. In this study, Nassarawa State University students' persecutory ideation is examined in relation to religious characteristics as predictors. A cross-sectional survey design was used in the study. In the study, a sample of 162 individuals was chosen at random from the student body. Both the independent and dependent variables were measured with three standardized tools. The use of multiple regression analysis was used to formulate and test two hypotheses. However, the researchers discovered that students' thoughts of being persecuted were jointly and significantly predicted by both hell anxiety and demonic conflict (F = 4.598, p=0.013, R2 = 0.105, r=0.325). Individually,  that demonic struggle had significant contributions to the prediction of persecutory ideation. (R2= 0.342, t=2.844; P < 0.05). Hell, anxiety did not significantly predict persecutory ideation. (R2= -0.043, t=-0.360; P > 0.05). These findings recommended that religious authorities consider. minimizing satanic and hell themes in their sermon and focusing on angels, heaven, forgiveness, and other positive concepts that promote a favorable perspective of God, thereby improving the mental health of its congregation. Additionally, psycho-spiritual therapy on the guidance of one's life by good supernatural beings like angels may assist in lessening religiously insured persecutory thinking.
PERAN BALAI LATIHAN KERJA KOMUNITAS DALAM MENINGKATKAN KETERAMPILAN SANTRI DI BIDANG DESAIN GRAFIS
Authors: Fajri Ahmad  , Dion Pratama Putra
Published: January 2024

Penelitian ini membahas Peran Balai Latihan Kerja Komunitas (BLKK) dalam Meningkatkan Keterampilan Santri di Bidang Desain Grafis Studi BLKK di Pondok Pesantren Kabupaten Agam. BLKK Pondok Pesantren di Agam dimulai pembangunannya 2019 dan dioperasikan tahun 2021 yaitu BLK Komunitas Pondok Pesantren Darul Makmur Baso dan BLK Komunitas Pondok Pesantren Tarusan Kamang. Penelitian ini menggunakan metode kualitatif dengan pendekatan studi lapangan yang bertujuan untuk mengetahui Peran Balai Latihan Kerja Komunitas di Pondok Pesantren di Kabupaten Agam dalam Meningkatkan Keterampilan Santri di Bidang Desan Grafis.

Hasil dalam penelitian ini mengungkapkan bahwa Peran Balai Latihan Kerja Komuniats di Kabupaten Agam dapat meningkatkan keterampilan santri di bidang desain grafis melalui beberapa kegiatan melalui pembelajaran yaitu :  Microsoft sebagai dasar untuk operasional computer bagi santri di BLK Komunitas di Pondok Pesantren Kabupaten Agam, santri dibekali penguasaan Microsoft Word, Power Point dan Exel. Kemudian mempelajari aplikasi corelDRAW untuk desain grafis, santri diberikan materi langsung dengan praktek membuat gambar sesuai dengan pembelajaran yang di terapkan di BLK komunitas mulai dari menetapkan suatu produk, filosofi suatu produk. Kegiatan  pelatihan yang dilakukan oleh santri di BLK Komunitas Pondok Pesantren di Kabupaten Agam mendapatkan respon yang positif dengan antusias peserta pelatihan.
The Implementation Of Nahwu Learning Based On Project Based Learning At Uin Imam Bonjol Padang
Authors: Febriani Suci , Yasmadi Yasmadi , Indah Lestari Sri
Published: January 2024

The educational background of students is an important domain for the success of learning nahwu, so that teachers need improvement in determining the learning to be applied. The PBL strategy requires students to observe and examine practice-based assignments on the object of study being studied, so this study aims to examine the effectiveness of Project based learning (PBL)-based nahwu learning at UIN Imam Bonjol Padang and how to implement PBL in nahwu learning. The research approach used was mixed method research with a quantitative sample of 35 students from two classes while data analysis used SPSS 16 and descriptive analysis based on observation and documentation. This study shows that learning nahwu using the PBL design is effective for students' cognitive understanding by calculating the t-test is greater than the t-table, while the implementation of PBL is based on needs analysis and practice searching for examples of sentences in the Qur'an. This study corroborates that learning nahwu using project based learning is able to increase cognitive understanding based on inductive techniques in tracing verses of the Qur'an. This study recommends further research to analyze nahwu learning strategies that are more varied with various samples and methods.
Perkembangan Koperasi Syariah di Indonesia
Authors: Edy Syahputra  , Muhammad Yusuf Harahap  , Noni Rozaini
Published: January 2024

Penelitian ini bertujuan untuk memperoleh informasi mengenai perkembangan koperasi syariah di Indonesia. Metode penelitian yang digunakan adalah penelitian kuantitatif deskriptif. Meskipun jumlah koperasi syariah jauh lebih kecil dibandingkan dengan jumlah koperasi secara keseluruhan, namun jumlah koperasi syariah cenderung meningkat dari tahun ke tahun. Pada tahun 2018, terjadi penurunan yang signifikan dalam jumlah koperasi secara keseluruhan, sedangkan jumlah koperasi syariah justru mengalami peningkatan. Pada tahun-tahun berikutnya, meskipun jumlah koperasi secara keseluruhan mengalami peningkatan, namun jumlah koperasi syariah tetap lebih rendah dibandingkan dengan tahun sebelumnya. Namun pada tahun 2021 dan 2022, jumlah koperasi syariah mengalami peningkatan yang signifikan. Dari hal ini dapat diambil kesimpulan bahwa meskipun jumlah koperasi secara keseluruhan mengalami fluktuasi dalam beberapa tahun terakhir, namun jumlah koperasi syariah cenderung terus meningkat. Hal ini mencerminkan bahwa masyarakat semakin memperhatikan dan mengapresiasi keberadaan koperasi syariah, dan permintaan terhadap koperasi syariah semakin meningkat di Indonesia.
Menakar Eksistensi Agama Pada Era Distrupsi
Authors: Murdan Muhammad Nur
Published: January 2024

Kehadiran agama di tengah-tengah masyarakat, selain memiliki fungsi yang memberikan pengaruh laten berupa peningkatan ibadah ritual, dia juga seyogyanya memberikan fungsi manifes berupa peningkatan ibadah aktual dalam membentuk pola pikir, tingkah laku dan berkebudayaan. Universalitas agama di tengah-tengah kehidupan masyarakat yang semakin kompleks dan plural, mengarahkan pada peran dan fungsi agama yang semakin luas pula cakupannya. Oleh karena keragaman bentuk dan intensitas interaksi beragama yang tercipta dalam masyarakat modern saat ini. Agama yang dahulu diyakini hanya berada dalam ruang sekat idea dan akal pikiran manusia, bagi masyarakat modern haruslah teraktualisasi secara nyata dan termanifestasikan dalam bentuk tindak dan prilaku interaksi social. Melalui kajian pustaka dan penyajian data secara deskriptif, penulis mencoba mengurai konsep agama dalam teori kemunculan agama itu sendiri, serta bagaimana bentuk-bentuk pemahaman keagamaan yang ada di sekitar kita. Agama sejatinya adalah merupakan tanggung jawab para pemimpin agama untuk memurnikan pemahaman masyarakat tentang agama dan mendorong kohesi sosial. Agama harus menjadi kekuatan pemersatu dan simbol integritas sosial.
A Case Report on Sutika Janya Shrirashoola with special reference to Migraine
Authors: Anita Sharma  , Jyoti Rani  , Sunita Yadav  , Rinkesh Vishnoi
Published: January 2024

In all Samhita different chapter is devoted to Shiro-Roga and detailed explanation about causes, clinical symptoms and treatment are discussed. In Shiro-Roga, Shirashoola is the main symptoms. In India, headache is the most common problem and found in maximum females. Causes can be anything from wrong diet, digestive problem, or stress of daily life. In present case, a 28 years female suffering from severe headache since last five years whose all diagnostic reports were normal. She had taken allopathic treatment for past five years but did not get significant relief. After taking detailed history, it was concluded that the headache was due to improper follow up of Sutika paricharya. Abhayanga-swedan, Nasya and Shirodhara along with oral medication was prescribed for 15 days. Patient gets relief in headache as well as associated symptoms within four days. Treatment was continued for two months and no reoccurrence was held after follow up also.
To Unravel and Evaluate the Efficacy of Madanadi Guda Varti in the Management of Constipation
Authors: Ranjana Urs KL  , KM Sweta
Published: January 2024

The word constipation refers to the bowel movements that are infrequent or hard to pass, causing discomfort the individual. The stools are often hard, dry and small making them painful or difficult to pass. Acharya Sushrutha has mentioned a special formulation called Madanadi Guda Varti in the context of Udararoga Chikithsa which has been lost with the passage of time and there are no references of its usage in modern times. The aim of this study is to evaluate the role of Madanadi Guda Varti in the management of constipation. Methodology: It is a case study of a 45 years old female patient who presented with the chief complaints of constipation with abdominal discomfort since 3 days. She was treated with the prepared Madanadi Guda Varti, a suppository, which was inserted per anus. Results: Complete evacuation of stools was achieved within 3 hours of insertion of the suppository. Discussion: Constipation is a common complaint and needs to be assessed irrespective of the specialties in medical practice. In this present case, Madanadi Guda Varti has shown promising results in the successful management of constipation with ease and is devoid of any complications. Further clinical studies are required to evaluate its effectiveness in larger sample.
Prevention of Induced Abortion - Effect on Pain. Systematic Review of a Database
Authors:   Medical University of Varna - Faculty of Public Health, Radeva Svetlana
Published: January 2024

Review of the current literature on pain prevention in induced abortion.An in - depth analysis of the guidelines of leading international and national organizations for prophylaxis of induced abortion-surgical and medicated abortion during the I-st and II-nd trimester in terms of pain response has been carried out. Shared with the author's many years of practical experience in order to assess the risks and benefits of the application of modern means of prophylaxis in artificial abortion and thus to improve the individual obstetric-gynecological practice. Methods: review of available literature from the last 10 years. Results and discussion:Paracetamol, oral lorazepam and nitric oxide do not improve pain control. Currently, the use of sedation is not recommended for Surgical abortion. Inhalation anaesthesia should not be used for sedation. Intravenous sedation with fentanyl and midazolam is recommended and safe - below 1.0% complications. In Medical abortion, 75.0% of women experience pain severe enough to require analgesia. The pain begins 2.5 to 4 hours after the use of perplex and lasts about an hour. During the extravehicular trimester, taking a higher number of doses intravenously is associated with more severe and frequent pain. In medicated abortion < 14 gw. non-steroidal anti-inflammatory drugs are recommended 30-45 minutes before the procedure. Non-steroidal medicines do not reduce the efficacy of urgencies. Routine administration of paracervical block before 13 gw. when using modern means for medicated abortion is unnecessary. Narcotic analgesics (Tramadol) do not affect pain in early Medical abortion and their routine use is not recommended. Conclusion:In Surgical abortion, analgesia is always offered. Most commonly, analgesics, such as non-steroidal anti-inflammatory drugs local anesthesia (paracervical block with Lidocaine 20.1%; or 10.2%),) and/ or sedation, supplemented with verbal sedation, are sufficient to relieve pain before mechanical cervical dilation and during uterine evacuation. The technique of deep paracervical injection of Lidocacaine at two points is recommended.
The Cardioprotective Effect of Nacetylcysteine on Doxorubicin Induced Cardiotoxicity in Heart Tissue of Rats.
Authors:   Çanakkale Onsekiz Mart University, Health Service Vocational College, Çanakkale-Turkey, Çakına Suat , İrkin Latife Ceyda ,   Çanakkale Onsekiz Mart University, Canakkale Faculty of Applied Sciences, Department of Fisheries Technology, Çanakkale-Turkey, Öztürk Şamil ,   Çanakkale Onsekiz Mart University, Health Service Vocational College, Çanakkale-Turkey
Published: January 2024

Doxorubicin (DOX) is a chemotherapeutic agent and is widely used in cancer treatment. There are some studies suggesting oxidative stress-induced toxic changes in the liver due to DOX administration. The aim of this study was to reveal the oxidative damage of DOX in liver tissue at molecular level and to evaluate the protective effect of N-acetylcysteine (NAC) against DOX oxidative damage. Twenty four rats weighing 150-200 g were randomly divided into four equal groups; group I : control, group 2: received a single dose of DOX, group 3: received NAC for 28 days and group 4: received a single dose of DOX, followed by NAC for 28 days. At the end of the experiment, heart tissues were taken from all animals. Malondialdehyde (MDA), Total Antioxidant Capacity (TAC), Total Oxidant Capacity (TOC) levels were determined in these samples by spectrophotometric methods. It was determined that TOC level increased, TAC levels decreased in the group given DOX compared to the control group. In addition, TAC levels increased in the DOX+NAC group (p0.05). It was concluded that DOX administration increased oxidative stress and NAC administration could prevent it. NAC caused modulatory effects on oxidative stress and antioxidant redox system in DOX-induced heart toxicity in the rat.
How Psychological Capital and Dark Triad Mediate the Effect of Entrepreneurial Attitude Orientation on Entrepreneurial Intention
Authors:   Faculty of Economics and Business, Udayana University, Bali, Indonesia, Putra I Putu Suardana , Artha Wibawa I Made ,   Faculty of Economics and Business, Udayana University, Bali, Indonesia, Riana I Gede ,   Faculty of Economics and Business, Udayana University, Bali, Indonesia, Manuati Dewi I Gusti Ayu ,   Faculty of Economics and Business, Udayana University, Bali, Indonesia
Published: January 2024

This study aims to analyze and explain the role of psychological capital, Machiavellianism, psychopathy, and narcissism in mediating the effect of entrepreneurial attitude orientation on entrepreneurial intentions. The population in this study is included in the limited population because the number of population used has been determined, namely active undergraduate students Class of 2021 at the Badung Regency State University, the sample of this study was 388 people. Data collection methods used were interviews and distributing questionnaires. The data analysis technique used is SEM-PLS. The results of this study show that entrepreneurial attitude orientation has a positive and significant effect on entrepreneurial intentions, Machiavellianism, narcissism, psychopathy and psychological capital. Machiavellianism has a positive and significant effect on entrepreneurial intentions. Narcissism has a positive and significant effect on entrepreneurial intentions. Psychopathy does not have a significant effect on entrepreneurial intentions. Psychological capital has a positive and significant effect on entrepreneurial intentions. Entrepreneurial attitude orientation has a positive and significant effect on entrepreneurial intentions with Machiavellianism, narcissism and psychological capital as mediating variables. Psychopathy cannot mediate the effect of entrepreneurial attitude orientation on entrepreneurial intentions.
Determinants of nutritional outcome among beneficiaries of Nutrition Rehabilitation Centre
Authors: Chauhan Dhwani N , Chauhan Naresh T , Patni Mohamed Anas Mohamed Faruk , Solanki Pinakini
Published: January 2024

Background: Under Mission Balam Sukham, children of 6 months to 5 years having severe acute malnutrition (SAM) along with complications are managed at Nutrition Rehabilitation Centre (NRC). They are admitted for 14 days with the provision of a nutritional diet and medicines. Objectives: To explore determinants of nutritional outcome of SAM children admitted at NRC Methods: A prospective cohort study was conducted comprising 63 children aged 6 months to 5 years having SAM along with complications admitted at NRC of New Civil Hospital, Surat (NCHS) for 10 months. Results: The majority of participants were boys (54%), 12-23 months of age (50.8%), and Grade III socioeconomic class (39.6%). The duration of stay ranged from 2-36 days. The average duration of stay was 12.78 + 6.49 days; 14.26 ± 5.99 days for boys and 11.10 + 6.73 for girls. 18.8% stayed at NRC for 14 days. The average weight gain was 5.46 g/kg/day. A significant improvement in weight was seen in boys (t=2.20, p<0.05), working mothers (t=2.44, p<0.01), exclusively breastfed children (t=3.62, p<0.01) of 6-11 months, full-term children of 12-23 months (t=4.0, p<0.05). The children of 12-23 months (t=2.90, p<0.01) and boys (t=2.15, p<0.05) showed significant improvement in underweight (WAZ). Wasting improved significantly in age below 36 months (p<0.05). 20.6% could achieve the target weight. Conclusion: NRC is an effective life-saving modality for malnutrition but its outcome is associated with factors like boys, exclusive breastfeeding, and full-term.
One Minute Preceptor Model – place or to replace
Authors: Tambolkar Sampada , Chavan Sanjay , Agarkhedkar Sharad , Salunkhe Shradha , Patil Manojkumar , Giri Purushottam
Published: January 2024

Introduction: Neher's 1992 One Minute Preceptor Model (OMP) offers a concise teaching approach based on five micro skills. Its acceptance led to research on efficacy, with a critical factor being the teacher's skill. In medical education, where small group teaching prevails, understanding factors influencing teaching effectiveness is crucial. Methods: Conducted at Dr. D Y Patil Medical College, the mixed-methods interventional study involved 32 Postgraduate Students and 4 Professors. A randomized controlled trial and qualitative interviews assessed the impact of OMP on teaching efficacy and gathered teachers' experiences. Results: Quantitative analysis revealed varied preferences among teachers for OMP and traditional methods, emphasizing the importance of teacher choice. Thematic analysis of qualitative interviews highlighted perceptions favouring OMP for efficiency and traditional methods for foundational teaching. Conclusion: An approach, to accommodate different teaching preferences, can enhance overall educational outcomes.
Effect of Educational Intervention on Awareness and Attitude regarding Voluntary Blood Donation among Rural People: A Quasi- Experimental Study
Authors: Goyal Palak , Kumar Amit , Khan Huma , Kumar Ravi
Published: January 2024

Donation of blood has always been considered as Humanitarian act. Despite the increasing demands for blood and its products, many people have little interest in donating blood. We undertook this study to assess the level of knowledge & attitude and to assess the effect of awareness talk regarding voluntary blood donation among rural people. Information from attendants of the patients visiting the Telemedicine Centre was collected using the Predesigned Pretested Semi open ended Interview Schedule. Out of 108 study subjects, 83 (76.8%) of study subjects didn’t knew their blood group. 52 (48.1%) said women cannot donate blood while they are pregnant or lactating. After the awareness talk, 78 (72.2%) were motivated for voluntary blood donation. There should be more awareness activities to promote voluntary blood donation in public.
WHO Growth Charts for Diagnosis of Malnutrition
Authors: Phadke Mrudula , Menon Pramila , Giri Purushottam , Bodhankar Uday , Prabhu Sanjay , Kinjawadekar Upendra
Published: January 2024

Child malnutrition is a major public health issue worldwide. An estimated 144 million children under age 5 are stunted, 47 million are wasted and 38.3 million have overweight or obesity. Around 45% of deaths among children under 5 years of age are linked to undernutrition.1 Measuring the growth of infants and children is an important part of child health surveillance and gives an idea about the nutritional status of the baby. Inadequate infant growth leads to under-nutrition in children in many low- and middle-income countries, which, if followed later in life by an increased intake of calories, can result in overweight or obesity and non- communicable diseases.
Cobertura vacunal contra infección por SARS-CoV-2 en Tucacas en 2023
Authors:   Tutora. Cátedra de Microbiología, Escuela de Medicina “José María Vargas”, Universidad Central de Venezuela, Pérez Janett
Published: January 2024

El control de la infección por COVID-19 dependió de medidas generales de higiene tales como practicar el lavado de las manos, usar consistente y correctamente una mascarilla de alta calidad, mejorar la ventilación y mantener la distancia, cuando sea posible, de la persona que está enferma o que dio positivo, y de la cobertura y efectividad de las vacunas específicas. La aceptación de estas últimas por la población fue clave para la prevención y control de la epidemia, y esta se vio influenciada por diferentes factores, que han sido englobados por la Organización Mundial de la Salud bajo el término de reticencia a la vacunación. Se realizó un estudio descriptivo, de corte transversal, no experimental, en el Ambulatorio “Dr. Gabriel Trompiz” de la población de Tucacas, en el período de marzo a mayo de 2023, con el objetivo de estimar la cobertura vacunal contra la COVID-19 y los factores asociados a la reticencia vacunal, aplicando una encuesta a través de la plataforma Google Forms.
PROBLEMATIKA NARKOTIKA KALANGAN GENERASI MUDA DI KABUPATEN SINJAI
Authors: Mudjrimin Jusri , Azhar Nur Muhammad
Published: January 2024

Penelitian ini bertujuan untuk mengetahui permasalahan (problematika) yang saat ini menggerogoti dan menghantui generasi masa depan bangsa. Problematika ini tak lain dan tak bukan ialah narkoba. Kehadiran narkoba sudah menjadi momok yang menakutkan bagi para generasi bangsa. Kehadirannya tidak hanya merusak fisik, akan tetapi juga merusak psikis dan mental generasi bangsa.  Bahaya bagi para pengonsumsi narkoba sudah menjadi rahasia umum. Bahkan pemerintah di Indonesia memberikan aturan hukum tersendiri bagi pengedar dan pengonsumsi narkoba. Lantas bagaimana proses adaptasi narkoba hingga dapat menjangkiti generasi muda sekarang? Sehingga mampu menjadi ancaman terbesar bagi para generasi muda. Hal paling penting dalam penelitian ini adalah langkah yang harus diambil untuk menghadapi penyalahgunaan narkoba yang saat ini menyerang generasi muda bangsa. Sejauh ini, pihak BNN sudah membentuk Badan Nasional Kabupaten berdasarkan Peraturan Presiden Nomor 23 Tahun 2010 yang memiliki tugas membantu tugas Badan Narkotika Nasional di tingkat kabupaten. Selain itu, Tak bisa dipungkiri peran keluarga, aparat negara, serta seluruh lapisan masyarakat turut serta memiliki andil dalam hal pencegahan dan penanggulangan narkoba
INCREASING THE EFFICIENCY OF IMPLEMENTATION OF THE FEDERAL STATE ENVIRONMENTAL SUPERVISION IN CHELYABINSK REGION
Authors:   Chelyabinsk State University, Alpatskaya Elena G. , Sadreev Artur L. ,   Chelyabinsk State University
Published: January 2024

The article discusses and clarifi es the concept of state environmental supervision, including analyzing the characteristics of environmental supervision as a state function (service), as well as identifying the features and problems of implementing federal state environmental supervision in the Chelyabinsk region, and offering recommendations to improve its effectiveness.
SELF-MANAGEMENT AS A FACTOR IN THE PROFESSIONAL DEVELOPMENT OF MANAGERIAL PERSONNEL
Authors:   Chelyabinsk State University, Yarusheva Svetlana A. , Babenko Anastasia V. ,   Chelyabinsk State University
Published: January 2024

This article discusses the concepts of “management” and “self-management”. The relationship between the professional development of managerial personnel and the development of self-management techniques is shown. Methods and ways of introducing self-management are given. Conclusions are drawn about the feasibility of using such techniques.
Development of Chromatographic Profile of Processed and non-processed Piper nigrum Linn.
Authors: Wanjari Anita , Rathi Bharat , Sonare Makrand , Wanjari Dinesh S , Wankhede Sukeshini
Published: January 2024

Advanced Chromatographic technique is one of the parameters for qualitative and quantitative assessment. In this study advanced chromatographic studies were conducted for the assessment of processed and non-processed Piper nigrum Linn.  Ayurvedic pharmaceutical is enriched in a wide range of preparations. The specific methods are applied for different formulation preparations.  Laghumaini vasant is a herbomineral formulation in which one of the ingredients is P. nigrum. In this formulation, the special process is advocated for P.nigrum.Linn. P nigrum should be soaked in buttermilk till the outer black covering is removed. There are possibilities that some changes may occur due to this process. Hence this study focused on the comparative assessment of processed P. nigrum and non-processed P.nigrum. For assessment chromatography techniques were used. HPLC and HPTLC methods were used to get more precise results.   High-Performance Thin Layer and High performance Liquid Chromatography were studied by using piperine as a reference standard. The piperine bands were seen in both processed and non-processed P.nigrum when analysed through both techniques. But, HPLC method has shown that piperine recovery is more in processed P.nigrum. In non-processed P.nigrum twenty seven peaks were observed but after processing with Buttermilk twenty one peaks were seen. The small six peaks were missing in processed P.nigrum.
Physicochemical and Phytochemical analysis of Wild and Cultivated Chitrak (Plumbago zeylanica Linn.)
Authors: Kamdi Payal , Gupta Rajkumar , Khobragade Pramod , Bahatkar Gayatri
Published: January 2024

Chitrak (Plumbago zeylanica Linn.) is a perennial shrub that grows slowly. Its roots become mature enough for medicinal use after a long time. The major source of Chitrak is wild and mainly roots are used in medicine preparation, so it needs to be uprooted and plant sustainability can’t be maintained. Therefore, this study was conducted to evaluate the physicochemical and phytochemical parameters of wild and cultivated root, stem, and leaves of Chitrak. Wild and cultivated Chitrak was collected from Kharangana forest and Herbal garden, MGACH&RC, Dist. Wardha respectively in an appropriate season as per the guidelines mentioned in Charak Samhita. Collected plant material was cleaned properly, shed-dried, ground, stored in an airtight container, and labeled for further study. For the Chromatographic study, a standard Plumbagin marker was procured from Sigma Aldrich Company, Bengaluru. This study concluded that all test samples contain Plumbagin but cultivated Chitrak root contains more Plumbagin than leaves and stem. So, according to ancient Ayurveda texts, the use of Chitrak root for various diseases as compared to leaves and stem is justified and ideal as far as the Plumbagin is concerned. But as leaves and stems also contain some amount of Plumbagin then it may be used for less chronic diseases or in patients who cannot tolerate the Tikshnatva and Ushnatva of Chitrak root. In this study, cultivated Chitrak root showed more Plumbagin than the wild source. So we can say that cultivated sources can be used in therapeutics instead of the wild sources after confirmation by clinical trials thereby minimizing the unauthorized collection practices and motivating the cultivation of this plant to some extent.
Wound Healing Potential of Different Extracts of Ehretia Laevis Roxb. (Khandu Chakka/Ajan Vruksha) Versus Silver Sulfadiazine in Burn Wound - Pre-Clinical Study
Authors: Thakre Rushikesh , Borkar Preeti , Harne Ketaki
Published: January 2024

Burns are also a leading cause of morbidity; millions who survive suffer from lifelong disability and disfigurements with resulting emotional trauma and stigma.  To identify the effective extract of Charma Vruksha( Ehretia Laveis Roxb.) in burn wound management and to generate empirical evidence for substantiation of burn wound healing by Kashaya Rasa ( Astringent taste)  through  experimental demonstration of the comparative wound healing property of Charma Vruksha ( Ehretia Laevis Roxb.)  this study was planned. This study is useful in broadening of  therapeutic aspect of Charma Vruksha( Ehretia Laveis Roxb.) plant. This is contribution to the literature related to ayurvedic sciences. The stated side effects of silver sulfadiazine  like pain, burning, itching, rash, cell death, destruction of red blood cells (in patients with G6PD deficiency), deficiency of granulocytes in the blood, low blood platelet count, low white blood cell count , can be minimized to some extent by the use of Charma Vruksha( Ehretia Laveis Roxb.)  plant leaves. Wound healing  measured by  histology score and wound contracture percentages. Average wound contracture  percentage was 36.83 % in Crude Extract group, 33.75% in Ethanol Extract group, 34.6 % in Chloroform Extract group , 42.41% in Aqueous Extract group, as compared to 38.08 %  of  Silver sulfadiazine. Histological score was 16 in Crude Extract group, 15 in Ethanol Extract group,15 in Chloroform Extract group , 16 in Aqueous Extract group as compared to 18 of  Silver sulfadiazine. Aqueous Extract was more effective in burn wound contracture by 11.37 % than Silver sulfadiazine Crude and Aqueous extract was more effective than ethanol and chloroform extract by 1 histological score but less effective by 2 histological score than Silver sulfadiazine.

Aqueous Extract is more efficacious in burn wound contracture by 11.37 % than Silver   sulfadiazine.