bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure S1 from Pancreatic CAF-Derived Autotaxin Drives Autocrine CTGF Expression to Modulate Protumorigenic Signaling
Authors: Volat Fanny , Medhi Ragini , Maggs Lauren Z. , Deken Marcel A. , Price Alice , Andrews Lauren , Clark Jonathan , Taylor Diane , Carruthers Alan , Taylor-Smith Ewan , Pacheco Natalia , Rudge Simon A. , Fraser Amy , Lopez-Clavijo Andrea F. , Sousa Bebiana C. , Johnson Zoë , Di Conza Giusy , van der Veen Lars , Shah Pritom , Sandig Hilary , Sharpe Hayley J. , Farrow Stuart
Published: February 2025

Supplementary Figure S1 shows the validation of ESTIMATE stromal and immune gene signatures and mRNA expression in tumour-rich and TME-rich samples.
Data from Modeling the Acute Mucosal Toxicity of Fractionated Radiotherapy Combined with the ATM Inhibitor WSD0628
Authors: Garcia Darwin A. , Rathi Sneha , Connors Margaret A. , Grams Michael , Vaubel Rachael A. , Bakken Katrina K. , Ott Lauren L. , Carlson Brett L. , Hu Zeng , Decker Paul A. , Eckel-Passow Jeanette E. , Burgenske Danielle M. , Zhong Wei , Trzasko Joshua D. , Herman Michael G. , Elmquist William F. , Remmes Nicholas B. , Sarkaria Jann N.
Published: February 2025

Abstract
Ataxia Telangiectasia–mutated (ATM) inhibitors are being developed as radiosensitizers to improve the antitumor effects of radiotherapy, but ATM inhibition can also radiosensitize normal tissues. Therefore, understanding the elevated risk of normal tissue toxicities is critical for radiosensitizer development. This study focused on modeling the relationship between acute mucosal toxicity, radiation dose, fractionation schedule, and radiosensitizer exposure. The ATM inhibitor WSD0628 was combined with single or fractionated doses of radiation delivered to the oral cavity or esophagus of Friend Leukemia virus B (FVB) mice. The potentiation by WSD0628 was quantified by a sensitizer enhancement ratio (SER), which describes the changes in radiation tolerance for radiation combined with WSD0628 relative to radiation-only regimens. WSD0628 profoundly enhanced radiation-induced acute oral and esophageal toxicities. For oral mucosal toxicity, the enhancement by WSD0628 with 3 fractions of radiation resulted in an SER ranging from 1.3 (0.25 mg/kg) to 3.1 (7.5 mg/kg). For the 7.5 mg/kg combination, the SER increased with increasing number of fractions from 2.2 (1 fraction) to 4.3 (7 fractions) for oral toxicity and from 2.2 (1 fraction) to 3.6 (3 fractions) for esophageal toxicity, which reflects a loss of the normal tissue sparing benefit of fractionated radiation. These findings were used to develop a modified biologically effective dose model to determine alternative radiation schedules with or without WSD0628 that result in similar levels of toxicity. Successful radiosensitizer dose escalation to a maximally effective therapeutic dose will require careful deliberation of tumor site and reduction of radiation dose volume limits for organs at risk.
Data from Pancreatic CAF-Derived Autotaxin Drives Autocrine CTGF Expression to Modulate Protumorigenic Signaling
Authors: Volat Fanny , Medhi Ragini , Maggs Lauren Z. , Deken Marcel A. , Price Alice , Andrews Lauren , Clark Jonathan , Taylor Diane , Carruthers Alan , Taylor-Smith Ewan , Pacheco Natalia , Rudge Simon A. , Fraser Amy , Lopez-Clavijo Andrea F. , Sousa Bebiana C. , Johnson Zoë , Di Conza Giusy , van der Veen Lars , Shah Pritom , Sandig Hilary , Sharpe Hayley J. , Farrow Stuart
Published: February 2025

Abstract
Autotaxin (ATX), encoded by ENPP2, is a clinical target in pancreatic ductal adenocarcinoma (PDAC). ATX catalyzes the production of lysophosphatidic acid (LPA), an important regulator within the tumor microenvironment (TME), yet the protumorigenic action of the ATX/LPA axis in PDAC remains unclear. In this study, by interrogating patient samples and cell line datasets, we show that the PDAC TME, rather than cancer cells, is responsible for the majority of ENPP2 expression and highlight a key role for cancer-associated fibroblast (CAF)-derived ATX in autocrine and paracrine protumorigenic signaling. Using the clinical-stage ATX inhibitor, IOA-289, we identified connective tissue growth factor (CTGF), also known as CCN2, as a downstream mediator of ATX signaling in the PDAC CAF-derived cell line, 0082T. Genetic ablation or pharmacologic inhibition of ATX in 0082T CAFs reduced CTGF secretion via modulation of LPA/LPA receptor signaling. Despite the loss of ATX function, extracellular levels of LPA were paradoxically increased, indicating a role for ATX beyond its enzymatic activity and suggesting a role for its LPA chaperone function in the LPA/LPA receptor signaling in CAFs. As CAFs are the main source for CTGF in the PDAC TME, these findings suggest a role for ATX in promoting a protumorigenic microenvironment via modulation of CAF secretion not only via its LPA-producing activity but also via its LPA chaperone function, providing a potential mechanism for the antitumor effects of ATX inhibition.
Figure 1 from Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence
Authors: McDonald Elizabeth S. , Pan Tien-Chi , Pant Dhruv K. , Troester Melissa A. , Kossenkov Andrew V. , Mankoff David A. , Mach Robert H. , Chodosh Lewis A.
Published: February 2025

A, PGRMC1 is overexpressed in human breast cancers of the basal subtype using PAM50. TMEM97 has the highest expression in luminal B tumors. B, PGRMC1 is overexpressed in hormone receptor–negative cancers. LDLR expression is highest in ER−/HER2+. TMEM97 has the highest expression in ER+/HER2+ tumors. C, PGRMC1 is overexpressed in smaller higher-grade tumors. LDLR and TMEM97 expression is highest in higher-grade tumors.
Cardiovascular and Renal Outcomes with Ertugliflozin by Baseline Use of Renin-Angiotensin-Aldosterone System Inhibitors or Diuretics, Including Mineralocorticoid Receptor Antagonist: Analyses from the VERTIS CV Trial
Authors: Cherney David Z.I. , Frederich Robert , Pratley Richard E. , Cosentino Francesco , Dagogo-Jack Samuel , Pong Annpey , Gantz Ira , Cater Nilo B. , Mancuso James P. , Masiukiewicz Urszula , Cannon Christopher P.
Published: February 2025

Introduction: VERTIS CV was a placebo-controlled cardiovascular (CV) outcome trial evaluating the sodium-glucose cotransporter 2 inhibitor ertugliflozin in patients with type 2 diabetes and established atherosclerotic CV disease. The aim of the current analyses was to evaluate VERTIS CV cardiorenal outcomes according to baseline use of renin-angiotensin-aldosterone system (RAAS) inhibitors or diuretics, including mineralocorticoid receptor antagonists (MRAs). Methods: Participants received ertugliflozin 5 mg, ertugliflozin 15 mg, or placebo once daily and were followed for a mean of 3.5 years. Prespecified CV and kidney outcomes were analyzed by Cox proportional hazard modeling in participant subgroups defined by baseline use of RAAS inhibitors (angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers) or diuretics (loop diuretics, non-loop diuretics, MRAs), with interaction testing to assess for treatment effect modification. Results: A total of 8,246 patients were randomized in VERTIS CV. At baseline, 6,686 (81%) participants were being treated with RAAS inhibitors, 3,542 (43%) with diuretics, 1,252 (15%) with loop diuretics, and 674 (8%) with MRAs. No significant interactions were observed for cardiorenal outcomes by baseline use of RAAS inhibitors or MRAs (pinteraction > 0.05 for all). Statistically significant interactions for a first event of hospitalization for heart failure (HHF) or CV death, and of HHF (alone), were observed with baseline use of diuretics, including loop diuretics, with an increased benefit of ertugliflozin treatment versus placebo. Conclusion: In VERTIS CV, baseline use of diuretics, particularly loop diuretics, identified a subgroup that demonstrated greater benefit with ertugliflozin on first HHF/CV death and HHF outcomes, with no modification of treatment effect observed with baseline use of RAAS inhibitors or MRAs. There was no evidence of treatment effect on the kidney composite outcomes by baseline use of RAAS inhibitors, diuretics, loop diuretics, or MRAs.
States and Their Diasporas
Authors: Vardanyan Hratsin , Hakobyan Mariam
Published: February 2025

In assessing the emerging role of diasporas in contemporary international relations, several states have established state structures to engage with their diasporas and develop special policies related to them. This article addresses the creation of such a policy, using the example of Soviet Armenia’s relations with the Armenian diaspora, highlighting the setup of institutions tasked to work with that diaspora, the main directions of this activity, and policy changes regarding the Armenian diaspora. The article demonstrates that by developing connections with the diaspora the Soviet authorities aimed above all to enhance the prestige of the Soviet Union abroad, especially in countries with substantial diasporic Armenian populations. Paradoxically, the ties they forged also facilitated the establishment and growth of institutional relations between the Soviet Republic of Armenia and the Armenian diaspora, leading to a significant increase in, and the pursuit of, activities related to specifically Armenian national and cultural identity.
A Name Riddle in a Samaritan Hebrew Poem
Authors: Stadel Christian
Published: February 2025

The article presents a section of an 18th-century Hybrid Samaritan Hebrew poem from the Day of Atonement liturgy that contains a name riddle. The text is translated, explained, and then compared to Jewish Hebrew name riddle poems from medieval Andalusia. Since the genre of Hebrew name riddle poems is generally thought to be unique to Andalusian poetry, the discovery of the Samaritan specimen is surprising. It is argued that the Jewish and Samaritan Hebrew name riddle poems developed independently from the Arabic muʿammā genre. The discovery testifies to the importance of the corpus of Samaritan Hebrew texts for the study of Hebrew literature.
An overview of the genus Osmanthus (Oleaceae) in Vietnam, with two new records and lectotypifications
Authors: DIEP TRAN THI NGOC , DOAN HA THI THANH , QUANG BUI HONG , AVERYANOV LEONID V. , LYSKOV DMITRY F. , SAMIGULLIN TAHIR H. , SENNIKOV ALEXANDER N. , NURALIEV MAXIM S.
Published: February 2025

An overview of the genus Osmanthus (Oleaceae) in Vietnam is provided. Four species are recognized, of which O. heterophyllus and O. yunnanensis are newly recorded for the country. Results of a molecular phylogenetic study are reported, and employed for clarification of the species idendity of the Vietnamese collections assigned to O. fragrans. In addition, uncertainties in phylogenetic relationships between the sections of Osmanthus are highlighted. For each species, taxonomic and nomenclatural notes are given, along with geographical distribution and analytical illustrations; accounts of the two newly recorded species are supplemented by morphological descriptions and notes on their ecology and phenology. Lectotypes are designated for three names currently treated within the genus Osmanthus. A key for identification of the Vietnamese species of Osmanthus is presented.
Checklist of sponges (Porifera) from the White Sea, Arctic
Authors: ERESKOVSKY ALEXANDER , MOROZOV GRIGORI
Published: February 2025

A checklist of the sponge fauna from the White Sea, Russia was compiled from published literature. This study provides a partial update to the “Checklist of sponges (Porifera) of the White Sea” published about 30 years ago. A total of 86 sponge species distributed among two classes of Porifera, Demospongiae and Calcarea, were identified in the White Sea. 18 of them are endemic to the White Sea. They belong to three subclasses and 10 orders of Demospongiae and two subclasses and two orders of Calcarea. In this paper we also give a brief overview of biogeography, vertical distribution and substrate preferences of the White Sea sponges.
Association Between Carotid Plaque Characteristics and Silent New Ipsilateral Ischemic Lesions After Carotid Artery Stenting
Authors: Yuan Jiehong , Yan Peng , Yang Zhengyu , Song Yanan , Yang Xinhao , Hu Xinyan , Wang Qiuting , Li Maoyu , Ma Xiaotong , Wang Xiang , Sun Qinjian
Published: February 2025

Silent new ipsilateral ischemic lesions (sNIIL) detected by diffusion-weighted imaging (DWI) are commonly observed after carotid artery stenting (CAS). We aimed to analyze the association of carotid plaque characteristics on Virtual Histology Intravascular Ultrasound (VH-IVUS) with sNIIL, which is not well understood. Among 128 patients who underwent CAS and VH-IVUS, 112 patients who underwent DWI within 72 h after CAS were included for analysis. VH-IVUS detected cross-sectional composition of plaques including necrotic core (NC), dense calcium (DC), fibrous (FI), and fibrofatty (FF) in each frame. Plaques with ≥3 consecutive thin-cap fibroatheroma (TCFA) or calcified thin-cap fibroatheroma (CaTCFA) frames were defined as vulnerable. Logistic regression was applied to evaluate the association between plaque characteristics and sNIIL. A total of 56 patients (50%) had sNIIL. Larger NC in the maximum NC frame (odds ratio [OR] = 1.35; 95% confidence interval [CI]: 1.03–1.75; P = .029) and defined vulnerable plaques (OR = 3.89; 95% CI: 1.68–9.01; P = .001) were associated with sNIIL. Incidence of sNIIL showed an escalating trend with the increase of quartiles of NC ( Ptrend = .010). The findings of this study suggest that composition and distribution characteristics of carotid plaques on VH-IVUS during CAS have potential clinical significance.
Do They Feel Heard? A Study of Canadian Secondary School Students’ Voices Around Violent Extremism
Authors: Dil Dilimulati Maihemuti , Hossain Dhali Helal , Ghosh Ratna
Published: February 2025

This paper examines the perspectives and experiences of Canadian secondary school students on violent extremism. Through interviews with students ( n = 36), the study highlights a significant lack of critical understanding of the topic. Although students perceive their teachers as competent, discussions on violent extremism are notably absent in classrooms, leading students to over-rely on informal sources such as social media, often rife with misinformation. Furthermore, many students tend to overemphasize Islamist extremism while showing no knowledge about right-wing or other forms of extremism. Some Muslim students report facing identity crises and discrimination due to prevailing discourses around Islam and violence.
Camel milk: White gold and its contribution to the sustainable development goals—A review
Authors: Chikha Maria , Faye Bernard
Published: February 2025

Camel milk plays a multifaceted and significant role in contributing to sustainable development goals (SDGs). This review aims to explore its impact on SDG 1 (No Poverty), SDG 2 (Zero Hunger), SDG 3 (Good Health and Well-being), SDG 5 (Gender Equality), SDG 8 (Decent Work and Economic Growth), SDG 12 (Responsible Consumption and Production), and SDG 13 (Climate Action). Camel milk alleviates poverty by providing crucial income and job opportunities for pastoral communities where alternative livelihoods are limited. Its rich nutritional value enhances food security, particularly in regions suffering from hunger and low agricultural productivity. Furthermore, its nutritional and medicinal properties contribute to public health and well-being, particularly in communities affected by food insecurity. The expanding camel milk industry promotes decent work and economic growth by fostering market diversification and growth while empowering women by creating economic opportunities within local communities. Camel milk production aligns with sustainable consumption and production patterns by requiring fewer resources and minimizing waste, and it strengthens resilience to climate change in vulnerable regions. Despite its potential, the camel milk industry faces hurdles such as high production costs, inadequate infrastructure, and limited market access. This article emphasizes the need for targeted efforts to overcome these challenges and highlights the potential of camel milk as a key driver of sustainable development in some of the world's most fragile regions and its contributions to sustainable development and improving the livelihoods of vulnerable communities worldwide. This article emphasizes the need for targeted efforts to overcome these challenges and highlights the potential of camel milk as a key driver of sustainable development in improving the livelihoods, especially of vulnerable communities across the world's most fragile regions.
Advancing moisture management in activewear: a novel dynamic testing approach for dynamic breathability of sportswear
Authors: Abedin Faisal , DenHartog Emiel A
Published: February 2025

This study presents a novel dynamic hot plate test for examining the exothermic and endothermic behaviors of textiles, emphasizing the dynamic conditions akin to physical activities. The method surpasses previous standards, for example ISO 16533 and the dynamic hot plate test developed by Naylor, by integrating sweating and wind simulations, thus offering a more precise assessment of fabric performance and physical sensation while wearing activewear. The investigation involved five fabric samples made from four different fiber types: 100% Merino wool, 100% polyester, 100% cotton, and 100% viscose.. The experimental setup, consisting of a 90-minute test with relaxation, activity, and drying phases, highlighted significant fabric-specific responses. Notably, polyester exhibited the highest heat loss rate at 388 W/m² during the activity phase, underscoring its potential for moisture management and cooling. Conversely, Merino wool showed the lowest heat loss rate at 212 W/m², suggesting a more stable microclimate. The dynamic conditions induced marked changes in microclimate temperature, humidity, and fabric surface temperatures, particularly noticeable when wind was introduced. These findings emphasized the importance of dynamic testing in evaluating activewear fabrics, suggesting that materials such as polyester offer excellent cooling and moisture management, whereas natural fibers such as Merino wool may enhance wearer comfort by maintaining a more consistent microclimate. This research contributes to refining fabric performance testing standards by emphasizing the significance of real-world dynamic conditions.
The Jam: Speculative-Mutant Pedagogies, Aesthetic Education Theory, and Becoming Joy with Children in a What If World
Authors: Woglom James F. , Jones Stephanie
Published: February 2025

Designing pedagogical spaces that affirm and embody the aesthetic theories that guide practitioners in art education (and education broadly speaking) isn’t always easy. Those theories call for experimentation, creative expression, protest, rejection of repetition, and a collective creation of newness and difference. In other words, these theories call for pedagogues to be comfortable with the unpredictable and emerging ways of being and becoming within specific entanglements of place, children, materiality, discourses, bodies, sound, affect, and so much more. In this graphica piece, the authors illuminate an enduring pedagogical event that was designed for and unfolded at an informal, no-fee, community-based education center for youth [second author] directed for six years. Affectionately called “The Clubhouse,” this neighborhood-embedded space centered critical aesthetic, relational ways of being that we have conceived of as a what if world. While James (first author) was aware that their carefully planned sessions with the youth were being carried away by the animated entanglement of children, music instruments, and an affirming space, and was uneasy that the “noise” produced by those participants might be bothering others or distracting from James’ own presumed learning objectives, they carried on and lived through theories of aesthetic education joyfully. The piece suggests that constraining forces that push toward compliance keep living theory and living theory joyfully at bay.

Maxine Greene, Felix Guattari, Herbert Marcuse, and Jacques Ranciére make guest appearances in this graphica, like wise and brilliant mentors offering affirmative and ethical ways of thinking, being, and doing with these young music-makers who have faced so much institutional rigidity and educational repetition. We also hope readers will enjoy and make new and different meanings with the inclusion of the Grateful Dead as a long-enduring band-event that has always been about creating newness and difference through experimentation far beyond conventions of art.

Researchers and practitioners can hopefully glean powerful glances into critical feminist posthumanist arts-infused research. They might also recognize the theoretical and practical promises of being with children in the noisy, unpredictable, and sometimes – maybe oftentimes or always – unsettling spaces created when we follow the courage and hope it takes to live out theories of justice and equity through aesthetic theories. Maybe, just maybe, in doing so, we can lean into our own mutant-speculative pedagogies and experience a little more justice and joy where we are.
European Society of Toxicologic Pathology—Pathology 2.0 Mass Spectrometry Imaging Special Interest Group: Mass Spectrometry Imaging in Diagnostic and Toxicologic Pathology for Label-Free Detection of Molecules—From Basics to Practical Applications
Authors: Vezzali Enrico , Becker Michael , Romero-Palomo Fernando , van Heerden Marjolein , Chipeaux Caroline , Hamm Gregory , Bangari Dinesh S. , Lemarchand Thomas , Lenz Barbara , Munteanu Bogdan , Singh Bhanu , Thuilliez Celine , Yun Seong-Wook , Smith Andrew , Vreeken Rob
Published: February 2025

Mass Spectrometry Imaging (MSI) is a powerful tool to understand molecular pathophysiology and therapeutic and toxicity mechanisms, as well as for patient stratification and precision medicine. MSI, a label-free technique offering detailed spatial information on a large number of molecules in different tissues, encompasses various techniques including Matrix-Assisted Laser Desorption Ionization (MALDI), Desorption Electrospray Ionization (DESI), and Secondary Ion Mass Spectrometry (SIMS) that can be applied in diagnostic and toxicologic pathology. Given the utmost importance of high-quality samples, pathologists play a pivotal role in providing comprehensive pathobiology and histopathology knowledge, as well as information on tissue sampling, orientation, morphology, endogenous biomarkers, and pathogenesis, which are crucial for the correct interpretation of targeted experiments. This article introduces MSI and its fundamentals, and reports on case examples, determining the best suited technology to address research questions. High-level principles and characteristics of the most used modalities for spatial metabolomics, lipidomics and proteomics, sensitivity and specific requirements for sample procurement and preparation are discussed. MSI applications for projects focused on drug metabolism, nonclinical safety assessment, and pharmacokinetics/pharmacodynamics and various diagnostic pathology cases from nonclinical and clinical settings are showcased.
A case of chondrosarcoma with costovertebral location in the posterior mediastinum: Resection and stabilization
Authors: Mutlu Fatma , Akçalı Ömer , Şanlı Aydın
Published: February 2025

Chondrosarcoma, a primary malignant bone tumor, rarely occurs in the vertebrae. We report a 29-year-old female with a 6 × 4.2 cm chondrosarcoma in the posterior mediastinum originating from the left 9th costa vertebral junction involving vertabrea corpus. Surgical resection performed involving posterior thoracotomy, 8–9th rib resection, 8–9th thoracal vertebrae partial corpectomy, laminectomy, spinal instrumentation, and chest wall stabilization. Pathology confirmed chondrosarcoma with safe margins. The patient remained recurrence-free for 9 years. This case highlights the importance of wide-margin surgical resection and multidisciplinary approaches for long-term survival in chondrosarcoma patients.
Failing DeVega tricuspid valve repair due to detachment of annuloplasty sutures: The Bowstring (Guitar string) sign
Authors: Shojaei Mohammad Amin , Salari Soheila , Hosseini Saeid
Published: February 2025

The DeVega annuloplasty procedure involves a double-running suture line along the circumference of the tricuspid annulus, encircling the anterior and posterior leaflets. A rare mechanical complication of this technique is the detachment of the suturing from the annulus, which can be referred to as the “bowstring sign” or “guitar string sign.”
Showcasing Studies of Conversational Motifs Within a Dynamic Dyadic Systems Perspective on Interpersonal Communication
Authors: Solomon Denise Haunani , Tian Xi , Li Yuwei , Li Shu Scott
Published: February 2025

This essay reports three projects that integrate linguistic features of speaking turns into the identification of conversational motifs, which are multiturn segments of dialog within interpersonal interactions. Study 1 focused on support for bereavement, used Linguistic Inquiry and Word Count data to augment characterizations of speaking turns based on speech act, and identified seven 5-turn conversational motifs. Study 2 examined serial argument conversations, used ratings of features and word count to differentiate speaking turns, and identified four conversational motifs within 1-minute segments of interaction. Study 3 analyzed conversations about public health campaign messages, considered functional and structural features of speaking turns, and identified four 4-turn conversational motifs. By elaborating the library of linguistic elements considered when operationalizing speaking turn types and showcasing alternative strategies for identifying conversation motifs, this essay extends recent advancements in a dynamic dyadic systems perspective on interpersonal communication.
The Big Picture
Authors: Carter C. Brooke
Published: February 2025

Once considered a novelty, videoconferencing is now making a major splash in the workplace. Effective lighting design can help fine-tune the production
Self-Perceptions of Aging and Loneliness Interact when Predicting Cognition in Older Adults
Authors: Fernández-Ballbé Óscar , Saiz Jesús , Gallardo-Peralta Lorena , Barrón- López de Roda Ana
Published: February 2025

There is growing interest in the link between self-perceptions of aging (SPA) and cognition in older adults. This study evaluates the relationship between SPA dimensions and objective cognition and its interaction with loneliness. A sample of 184 community-dwelling Spanish older adults aged 65 and above was recruited. The short form of the Aging Perceptions Questionnaire (APQ-S) was used along with a neuropsychological battery and sociodemographic and health measures. The findings reveal links between negative consequences and processing speed; chronic time and inhibition; cyclical time and selective and alternating attention; and emotional representations and inhibition, selective attention, and working memory. SPA dimensions were found to moderate the relationship of loneliness on processing speed and selective attention. This study offers evidence of the differential link between SPA dimensions and cognition as well as their interaction with loneliness, which is valuable for designing intervention programs that promote cognitive health and active aging.
Bioéthique et inclusion : Le rôle des changements réglementaires dans la légitimation basée sur les émotions des consommateurs stigmatisés
Authors: Mimoun Laetitia
Published: February 2025

Cet article repose sur une étude de données médiatiques entourant l’introduction de la loi de bioéthique de 2021 qui a permis aux couples lesbiens et aux femmes célibataires d’accéder aux technologies de procréation médicalement assistée (c’est-à-dire aux traitements de l’infertilité). L’article examine comment cette évolution législative influence les hiérarchies de règles sentimentales et comment de telles interactions influencent la légitimité de marché. Ce faisant, l’article contribue à la recherche sur les émotions collectives et les sentiments de marché en élargissant notre compréhension du rôle que jouent les règles sentimentales dans la légitimation de certains segments de consommateurs et en éclairant le rôle des acteurs étatiques dans la formation des sentiments moraux de marché. Cette étude améliore également notre compréhension des trajectoires d’inclusion des consommateurs en mettant en évidence un cas de dynamique d’inclusion motivée par la réglementation dans un marché controversé.
Worse Weather Amplifies Social Media Activity
Authors: Minor Kelton , Moro Esteban , Obradovich Nick
Published: February 2025

Humanity spends an increasing proportion of its time interacting online, yet—given the importance of social media to human welfare—the external factors that regularly shape online behavior remain markedly understudied. Do environmental factors alter rates of online social activity? We conducted two large natural experiments to investigate how worse weather conditions affect social-media use in the United States, analyzing over 3.5 billion posts from Facebook and Twitter (now X) between 2009 and 2016. We found that extreme temperatures and added precipitation each independently amplified social-media activity, effects that persisted within individuals. Compounded weather extremes produced markedly larger increases in social-media activity. Days colder than −5 °C with 1.5 to 2 cm of precipitation elevated social-media activity by 35%, nearly triple the surge seen on New Year’s Eve in New York City. Our study highlights that environmental conditions play a critical—but overlooked—role in shaping digital social interaction.
Political and transformative uses of time
Authors: Gokmenoglu Birgan , Ruggero E. Colin
Published: February 2025

Taking time as a political relation and politics as a temporal one, our focus in this Special Issue is on contemporary case studies from a variety of geographical and political contexts. Using a wide range of methodological and theoretical approaches from across the social sciences, we use a temporal lens to study structures of power and inequality. Attentive to uncertainty, indeterminacy, and contingency, the contributions to this issue are especially attuned to the political salience of collectively produced temporal agency. Based on empirical case studies, the articles in this collection apply, critique, refine, and extend existing temporal concepts to uncover the political and transformative uses of time. Conscious of time's intimate entanglement with power, inequality, social transformation, and social justice, we hope to contribute a politically relevant, empirically and conceptually rich collection of articles to critical time studies and to studies of politics, social change, and social movements.
Nurse misinformation and the digital era: Abrogating professional responsibility
Authors: Charles Christopher M , Grace Pamela J
Published: February 2025

In the current digital era, reliance on technology for communication and the gathering and dissemination of information is growing. However, the information disseminated can be misleading or false. Nurses tend to be trusted by the public, but not all information brought to the public forum is well-informed. Ill-informed discussions have resulted in harm to individuals who take such information as fact and act on it. As technology continues to evolve and fact versus fiction becomes more challenging to discern, it is critical that nurses recognize their ethical responsibility to the public in providing information for which sound evidence exists. This analysis will explore medical misinformation through concepts such as confirmation bias and the politicization of science. Also, the impact of nurses not recognizing the power and responsibility associated with using their credentials in public fora, even when the central motivator is that they believe they are helping other individuals. Using nursing goals and perspectives, we will discuss the ethical responsibility of nurses to be aware of the soundness of what they think they know. Utilizing ideas of professional responsibilities, as outlined by professional codes of ethics as well as the ethical principles of non-maleficence and veracity, we explore the problem of nurses propagating misinformation and suggest strategies to enhance nurse awareness of their ethical responsibilities for veracity and transparency regarding what is known and what is not.
“Effectiveness of a Multimodal Teaching Program on Nurses” Knowledge Acquisition, Practice, and Perception of Neurodevelopmental Supportive Care in NICU: A Non-randomized Controlled Trial
Authors: A Raghu V , Vatsa Manju , Gupta Neeraj , Latha ** , T Thuileiphy
Published: February 2025

Introduction

Developmental supportive care (DSC) gradually gaining recognition and adoption in NICUs. This study aimed to assess the effectiveness of a multimodal teaching program (MMTP) on nurses’ knowledge acquisition, practices, and perception of neurodevelopmental supportive care (NDSC).

Methods

A non-randomized controlled trial with a one-group pre-test–post-test design was employed to evaluate the efficacy of MMTP on NDSC among the 55 nurses working in the NICU. Pre and post-assessment followed by one-month follow-up data was collected using a self-administered questionnaire for knowledge, an observation checklist for practice assessment and a Likert scale to assess the perception.

Results

This study findings showed that the mean (SD) score at pre-test, post-test-I and II were 12.18 (3.15), 17.2 (1.04) and 19.1 (1.82), respectively; MD (95% CI) between pre-test and post-test-I = 5.06 (3.84-6.27), P = .001 and MD (95% CI) between pre-test and post-test-II = 6.90 (5.78-8.09), P = .001. After the MMTP, 90%-100% of nurses exhibited adequate practice skills in NDSC, with 81.6% of participants reporting a positive perception toward it.

Conclusion

The MMTP effectively improved and sustained nurses’ knowledge and practices regarding NDSC.
A critical feminist analysis of women's football in Türkiye: Challenges, opportunities, and societal implications
Authors: Avcil Ceren , Dalaman Zeynep Banu
Published: February 2025

This study employs a critical feminist perspective to examine the development and institutionalization of women's football in Türkiye, focusing on socio-economic, cultural, and institutional factors, as well as regional disparities. The theoretical framework draws on key feminist theories, including Butler's gender performativity, De Beauvoir's social construction of gender, and Crenshaw's intersectionality. Utilizing a phenomenological research design, the study conducted semi-structured interviews with 12 female players and 4 male coaches and managers from two teams in different regions of Türkiye, complemented by two focus group discussions. The analysis revealed five primary themes: perceptions of gender differences, visibility challenges, financial conditions, regional disparities, and institutional capacity. Results highlight significant East/West regional disparities reflecting broader socio-economic divides, with players from the Eastern region facing greater challenges in terms of resources and societal acceptance. The study contributes to understanding women's football development as a potential catalyst for social change, particularly in addressing issues such as child marriage in eastern regions. Furthermore, this research underscores the need for intersectional policy approaches that address the complex interplay of gender, geography, and socio-economic factors in shaping women's football participation and development in Türkiye.
Does Hearing Improve Following Primary Cleft Palate Repair?
Authors: Stylianou Theodoros , Tay Jing Qin , Soylu Erdinc , Geyer Marcel , Fallico Nefer
Published: February 2025

Objective

To establish the effect of cleft palate repair on hearing outcomes in children with glue ear and conductive hearing loss undergoing elective primary palatoplasty.

Methods

A retrospective chart review of all patients who underwent cleft palate repair (isolated cleft palate [CPO], unilateral cleft lip and palate [UCLP], and bilateral CLP [BCLP]) between 2020 and 2022 in a single institution. Patient demographic data and cleft type were recorded. Statistical analysis was performed on pre and postoperative audiology reports.

Results

A total of 42 children (20 males, 22 females) had cleft palate repair within the study period. The mean age at primary repair was 15.2 months (range: 8-33 months). Seven of the 42 children were syndromic and 4 had Pierre Robin sequence. Preoperatively, 36 patients (86%) were diagnosed with conductive hearing loss. A single patient had hearing aids preoperatively due to severe hearing loss. One patient had grommets inserted at the time of palatoplasty. Postoperatively, all 42 patients attended their follow-up audiology appointments (100%); 20 patients (48%) had improved hearing levels, 18 (43%) had similar hearing levels, and 4 (9%) had worse hearing levels. When stratified by cleft type (25 CPO, 9 BCLP, and 8 UCLP) no difference was noted. Four patients required hearing aids postoperatively.

Conclusions

This study confirms that primary cleft palate repair has a positive impact on audiology outcomes in patients with cleft. These findings suggest that primary cleft palate repair may improve hearing at an early stage, possibly by contributing proactively to restoring eustachian tube function and normalizing middle ear ventilation before glue ear and associated conductive hearing loss improve with patient maturity.
A new method for the solvability of mixed hemivariational inequalities
Authors: Tan Xin , Zhou Min
Published: February 2025

This paper studies the solvability of mixed hemivariational inequalities. A new method for analyzing solvability is proposed, which is based on the projection iteration technique to construct two sequences. At each iteration step, solving hemivariational inequalities is necessary. We then show that the sequences converges strongly to the solution of mixed hemivariational inequalities. This allows the use of the solvability of hemivariational inequalities to guarantee the solvability of mixed hemivariational inequalities. Finally, the applicability of the results is illustrated by the Stokes model of a generalized Newtonian incompressible fluid with nonsmooth nonconvex slip boundary conditions.
Identifying antecedents and mechanisms of age-based stereotype threat
Authors: Coulon Sophie , von Hippel Courtney , Peters Kim
Published: February 2025

Older employees are stereotyped at work (e.g., as technophobic), making them susceptible to stereotype threat, or the concern of being reduced to a negative stereotype. Although consequences of age-based stereotype threat have been identified (e.g., poorer job attitudes), far less is known about workplace triggers and underlying mechanism. Three studies aimed to identify the workplace antecedents and mechanism underlying stereotype threat. Together, Studies 1a and 1b identified 10 potential antecedents associated with stereotype threat (e.g., being overlooked for training). Mediation analysis revealed that experiencing any of the potential antecedents was associated with increased age salience, which, in turn, was associated with greater feelings of stereotype threat. Study 2 manipulated three of the potential antecedents through short videos and found that experiencing the antecedents led to increased age salience and stereotype threat. This experimental approach complemented the cross-sectional nature of Studies 1a and 1b, providing evidence for the proposed causal pathways.
Theorizing ethnographically: No shares without acknowledgement
Authors: Li Tania Murray
Published: February 2025

As anthropologists have long recognized, a share is not a gift. Shares belong to owners. Only someone acknowledged to be the owner of a share of valued goods is entitled to demand the portion that properly belongs to them. This insight invites further ethnographic research and theorizing. What kind of person is acknowledged to be the proper owner of a share? What are the conditions under which demands based on ownership are recognized or disallowed? Where acknowledgement is lacking, how can it be achieved? To address these questions, I draw on my ethnographic research in Indonesia. Indigenous highlanders I encountered in Sulawesi in the 1990s grounded ownership in an individual's labour. Contra popular assumptions about the naturally communitarian nature of Indigenous people, social membership in a kin group or community furnished scant grounds for sharing valued goods such as labour or food. Research I conducted with Pujo Semedi in 2010–2015 in Kalimantan's oil palm zone indicated that villagers whose land had been occupied by plantation corporations were convinced they were rightful owners of a share of plantation wealth. Yet, racial tropes inherited from the colonial era together with the plantations’ social, juridical and spatial arrangements impeded acknowledgement. Plantation corporations and their government allies saw no grounds on which to compensate villagers for their losses, include them in benefits or involve them in plantation affairs. Drawing upon these ethnographic sources and comparative material, I further theorize why there can be no sharing without acknowledgement.
Upscaling a sharing approach
Authors: Widlok Thomas
Published: February 2025

Parallels between person-to-person sharing and centrally institutionalized forms of redistribution have been noted repeatedly but also need to be assessed critically. When sharing is defined as the allocation of economic goods without calculating returns we may ask whether this also includes redistributive large-scale institutions such as forms of public pooling, crowd-based digital platforms or taxation. Can sharing be upscaled to institutional settings at larger scales or is it tied to intimate contexts of face-to-face interaction? This contribution discusses this question by giving particular attention to the way in which the presence of social agents is shaped in sharing and how it is altered when it is upscaled institutionally. On the basis of comparisons between ethnographic observations in small and large settings, processes of recognizing, mediating, virtualizing and temporalizing presence are identified. Finally, some lessons from research on sharing in intimate settings are being drawn for assessing the role that sharing may play to counter inequalities in larger institutional settings.
Multimedia interactive creative dance choreography integrating intelligent chaotic art algorithms
Authors: Shi Yuanying , Han Songyuan
Published: February 2025

Creative dance choreography involves the exploration of movement as a form of artistic expression, often characterized by innovative and spontaneous elements. Interactive multimedia enhances the art form by integrating technology, enabling real-time audience engagement and dynamic visual effects. Traditional choreography often adheres to fixed patterns, which can limit improvisation and reduce audience participation. The objective of the study is to integrate the chaotic art algorithm within multimedia interactive dance choreography, enhancing both the creative process and audience engagement while producing novel movement patterns. Data were collected through motion capture technology and video recordings. The preprocessing phase included noise reduction and normalization of the movement data. Feature extraction using principal component analysis (PCA) techniques analyzed the captured data, identifying key attributes such as speed, trajectory, and synchronization. The study proposed a simulation-based intelligent chaotic optimized generative adversarial network (ICO-GAN) that enhances dance choreography by generating diverse, unpredictable movement patterns, optimizing performance through chaotic art algorithms, and fostering innovative, engaging interactions between dancers and multimedia elements. The result shows that the proposed ICO-GAN method enriched the choreography by generating diverse movement patterns that were seamlessly incorporated into performances based on precision (94%), recall (92%), accuracy (97%), and F1-score (93%). This innovative approach opens new avenues for exploration in dance and technology, offering expanded possibilities for artistic expression and interaction.
Thoracic Endovascular Aortic Repair for Aortic Arch Penetrating Atherosclerotic Ulcer Using Castor Single-Branched Stent-Graft With Zone 2 Landing
Authors: Li Xiaoye , Fan Jiefu , Zhang Lei , Song Chao , Zhang Hao , Xia Shibo , Li Haiyan , Lu Qingsheng
Published: February 2025

Background:

This study evaluated the feasibility and safety of thoracic endovascular aortic repair (TEVAR) for aortic arch penetrating atherosclerotic ulcer (PAU) using Castor single-branched stent-graft with zone 2 landing.

Methods:

Between May 2020 and April 2022, a total of 25 aortic arch PAU patients were treated by TEVAR with Castor single-branched stent-graft. Outcomes included technical success, perioperative and follow-up morbidity and mortality, and patency of left subclavian artery (LSA).

Results:

All patients had aortic arch PAU with intramural hematoma (IMH). The proximal landing zone for all patients was in zone 2, which was between the distal edge of the left common carotid artery and proximal edge of LSA, in all cases. Technical success was achieved in all cases. During hospitalization after the operation, 1 patient died of gastrointestinal bleeding, and 2 patients (8.0%) had ischemic stroke. At a median follow-up of 29 months (interquartile range [IQR], 24-30 months), 2 (8.0%) patients died, including 1 ischemic stroke and 1 hemorrhagic stroke. One patient (4.0%) had reintervention owing to retrograde type A aortic dissection (RTAD) 2 months after the operation, and was successfully treated with aortic root remodeling, ascending aorta and total aortic arch replacement and frozen elephant trunk procedure. No endoleak or LSA occlusion occurred. The maximal diameter of aorta at proximal (30.2±2.4 mm vs 31.2±3.0 mm; p>0.05) and distal (25.7±2.8 mm vs 24.5±2.3 mm; p>0.05) landing zone showed no significant difference before and after the operation.

Conclusions:

The TEVAR for aortic arch PAU using Castor single-branched stent-graft is a safe and efficient option with zone 2 landing.

Clinical Impact

For patients with diagnosis of PAU with IMH, TEVAR with Castor single-branched stent-graft presents low mid-term mortality and morbidity rate, which should be considered as an optimal option when proximal landing zone is insufficient and revascularization of left subclavian artery (LSA) is needed. With Castor single-branched stent-graft, LSA could be revascularized easily and accurately.