bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effect of Tissue-Mimicking Phantom Compressibility on Magnetic Hyperthermia
Authors: Kaczmarek Katarzyna , Mrówczyński Radosław , Hornowski Tomasz , Bielas Rafał , Józefczak Arkadiusz
Published: May 2019

During hyperthermia, magnetite nanoparticles placed in an AC magnetic field become a source of heat. It has been shown that in fluid suspensions, magnetic particles move freely and generate heat easily. However, in tissues of different mechanical properties, nanoparticle movement is limited and leads to a small temperature rise in tissue. Therefore, it is crucial to conduct magnetic hyperthermia experiments in similar conditions to the human body. The effect of tissue-mimicking phantom compressibility on the effectiveness of magnetic hyperthermia was investigated on agar phantoms. Single and cluster nanoparticles were synthesized and used as magnetic materials. The prepared magnetic materials were characterized by transmission electron microscopy (TEM), and zeta potential measurements. Results show that tissue-mimicking phantom compressibility decreases with the concentration of agar. Moreover, the lower the compressibility, the lower the thermal effect of magnetic hyperthermia. Specific absorption rate (SAR) values also proved our assumption that tissue-mimicking phantom compressibility affects magnetic losses in the alternating magnetic field (AMF).
Modification of the Raman Spectra in Graphene-Based Nanofluids and Its Correlation with Thermal Properties
Authors: Rodríguez-Laguna María del Rocío , Gómez-Romero Pedro , Sotomayor Torres Clivia M. , Chavez-Angel Emigdio
Published: May 2019

It is well known that by dispersing nanoparticles in a fluid, the thermal conductivity of the resulting nanofluid tends to increase with the concentration of nanoparticles. However, it is not clear what the mechanism behind this phenomenon is. Raman spectroscopy is a characterization technique connecting the molecular and macroscopic world, and therefore, it can unravel the puzzling effect exerted by the nanomaterial on the fluid. In this work, we report on a comparative study on the thermal conductivity, vibrational spectra and viscosity of graphene nanofluids based on three different amides: N, N-dimethylacetamide (DMAc); N, N-dimethylformamide (DMF); and N-methyl-2-pyrrolidinone (NMP). A set of concentrations of highly stable surfactant-free graphene nanofluids developed in-house was prepared and characterized. A correlation between the modification of the vibrational spectra of the fluids and an increase in their thermal conductivity in the presence of graphene was confirmed. Furthermore, an explanation of the non-modification of the thermal conductivity in graphene-NMP nanofluids is given based on its structure and a peculiar arrangement of the fluid.
Electrospinning of Cellulose Nanocrystal-Filled Poly (Vinyl Alcohol) Solutions: Material Property Assessment
Authors: Sanders J. Elliott , Han Yousoo , Rushing Todd S. , Gardner Douglas J.
Published: May 2019

Poly (vinyl alcohol) (PVA) and cellulose nanocrystals (CNC) random composite mats were prepared using the electrospinning method. PVA/CNC mats were reinforced with weight concentrations of 0, 20 and 50% CNC (w/w) relative to PVA. Scanning electron microscopy was used to measure the fiber diameter, which ranged from 377 to 416 nm. Thermogravimetric analysis (TGA) confirmed the presence of CNC fibers in the mat fibers which were not visible by scanning electron microscope (SEM). Mechanical testing was conducted using ASTM D 638 on each sample group at 10 mm min−1. Neat PVA and PVA/CNC mats were heat treated at 170 °C for 2h hours, and the morphological structure was maintained with some fiber diameter reduction. Mechanical property results after heat treatment showed a decrease in tensile strength, an increase in tensile stiffness and a decrease in strain to yield (%). This effect was attributable to enhanced diffusion bonding of the mat fiber intersections. The CNC fibers also increased mat stiffness, and reduced strain to yield in non-treated mats. The use of CNCs show potential for compounding into bulk polymer composites as a reinforcement filler, and also show promise for chemical crosslinking attributable to the –OH groups on both the PVA, in addition to esterification of the vinyl group, and CNC.
Dietary Flaxseed as a Strategy for Improving Human Health
Authors: Parikh Mihir , Maddaford Thane G. , Austria J. Alejandro , Aliani Michel , Netticadan Thomas , Pierce Grant N.
Published: May 2019

Flaxseed is a rich source of the omega-3 fatty acid, alpha linolenic acid, the lignan secoisolariciresinol diglucoside and fiber. These compounds provide bioactivity of value to the health of animals and humans through their anti-inflammatory action, anti-oxidative capacity and lipid modulating properties. The characteristics of ingesting flaxseed or its bioactive components are discussed in this article. The benefits of administering flaxseed or the individual bioactive components on health and disease are also discussed in this review. Specifically, the current evidence on the benefits or limitations of dietary flaxseed in a variety of cardiovascular diseases, cancer, gastro-intestinal health and brain development and function, as well as hormonal status in menopausal women, are comprehensive topics for discussion.
Brazilian Food Truck Consumers’ Profile, Choices, Preferences, and Food Safety Importance Perception
Authors: Isoni Auad Lígia , Cortez Ginani Verônica , dos Santos Leandro Eliana , Stedefeldt Elke , Costa Santos Nunes Aline , Yoshio Nakano Eduardo , Puppin Zandonadi Renata
Published: May 2019

This study aimed to investigate food truck consumers’ profile, choices, preferences, and food safety importance perception. We conducted structured interviews with a convenient sample of 133 food truck consumers in the Federal District, Brazil. Most of the participating consumers were married (52%) and female (56%), who had completed at least tertiary school (81%). The interviews revealed that most food truck consumers eat from food trucks once or twice a week (96%), usually near home (74%), and have an average per capita expenditure of approximately US $5 to US $9.99 (70%). Hamburgers and sandwiches are the most popular food among consumers (72%). Consumers indicated that taste (30%) was the most important reason to choose a food truck and that poor vehicle hygiene (30%) was the main point assigned for not opting for a food truck. Food hygiene and vendors’ personal hygiene were considered important by consumers when eating from food trucks (78% and 80%, respectively). Considering all food truck consumers interviewed and the questions about food safety importance perception, the minimum score was 1 and the maximum was 2.9, with a mean score of 1.68 (SD = 0.46), indicating a high level of perceived importance. The instrument of food safety importance perception presented a Cronbach’s alpha coefficient of 0.73, indicating good internal consistency. No significant differences were observed in the food safety importance perception scores in gender (0.192), marital status (0.418), level of education (0.652) or food safety training (0.166). However, significant differences were found in the food safety importance perception scores for age (0.026) and the presence of children (0.001). The findings of this study indicate that there remains the need for consumers to comprehend their role in the food supply chain. Food safety and food handling practices are of public concern, and strategies are required to prevent foodborne diseases. Future public health interventions aiming to increase consumer knowledge and awareness of food safety should be emphasized.
Glucose Tolerance Test and Pharmacokinetic Study of Kaempferia parviflora Extract in Healthy Subjects
Authors: Sripanidkulchai Bungorn , Mekjaruskul Catheleeya , Areemit Rosawan , Cheawchanwattana Areewan , Sithithaworn Jiraporn
Published: May 2019

Kaempferia parviflora Wall. ex Baker (KP), Krachaidam in Thai or Thai ginseng, is a herbal medicine that has many potential pharmacological effects. The effect of KP extract on blood glucose level in rodent was reported. This study focused on the oral glucose tolerance test and pharmacokinetic study in healthy volunteers administered with KP extract (90 and 180 mg/day, placebo). The oral glucose tolerance tests were performed at baselines and 28-days of administration. The pharmacokinetics were determined after a single dose administration of the tested products using 3,5,7,3′,4′-pentamethoxyflavone (PMF) and 5,7,4′-trimethoxylflavone (TMF) as markers. The results showed that glucose metabolism via oral glucose tolerance test was not affected by KP extract. Blood glucose levels of volunteers at 120 min after glucose loading were able to be returned to initial levels in placebo, KP 90 mg/day, and KP 180 mg/day groups both at baseline and 28-days of administration. The results of the pharmacokinetic study revealed that only TMF and PMF, but not 5,7-dimethoxyflavone (DMF) levels could be detected in human blood. The given doses of KP extract at 90 and 180 mg/day showed a linear dose-relationship of blood PMF concentration whereas blood TMF was detected only at high given dose (180 mg/day). The half-lives of PMF and TMF were 2–3 h. The maximum concentration (Cmax), area under the curve of blood concentration and time (AUC), and time to maximum concentration (Tmax) values of PMF and TMF estimated for the 180 mg/day dose were 71.2 ± 11.3, 63.0 ± 18.0 ng/mL; 291.9 ± 48.2, 412.2 ± 203.7 ng∙h/mL; and 4.02 ± 0.37, 6.03 ± 0.96 h, respectively. PMF was quickly eliminated with higher Ke and Cl than TMF at the dose of 180 mg/day of KP extract. In conclusion, the results demonstrated that KP extract had no effect on the glucose tolerance test. In addition, this is the first demonstration of the pharmacokinetic parameters of methoxyflavones of KP extract in healthy volunteers. The data suggest the safety of the KP extract and will be of benefit for further clinical trials using KP extract as food and sport supplements as well as a drug in health product development.
Effect of 12-Week Daily Intake of the High-Lycopene Tomato (Solanum Lycopersicum), a Variety Named “PR-7”, on Lipid Metabolism: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study
Authors: Nishimura Mie , Tominaga Naoki , Ishikawa-Takano Yuko , Maeda-Yamamoto Mari , Nishihira Jun
Published: May 2019

Tomato (Solanum lycopersicum) is a rich source of lycopene, a carotenoid that confers various positive biological effects such as improved lipid metabolism. Here, we conducted a randomized, double-blind, placebo-controlled, parallel-group comparative study to investigate the effects of regular and continuous intake of a new high-lycopene tomato, a variety named PR-7, for 12 weeks, based on 74 healthy Japanese subjects with low-density lipoprotein cholesterol (LDL-C) levels ≥120 to <160 mg/dL. The subjects were randomly assigned to either the high-lycopene tomato or placebo (lycopene-free tomato) group. Each subject in the high-lycopene group ingested 50 g of semidried PR-7 (lycopene, 22.0–27.8 mg/day) each day for 12 weeks, while subjects in the placebo group ingested placebo semidried tomato. Medical interviews were conducted, vital signs were monitored, body composition was determined, and blood and saliva samples were taken at weeks 0 (baseline), 4, 8, and 12. The primary outcome assessed was LDL-C. The intake of high-lycopene tomato increased lycopene levels in this group compared to levels in the placebo group (p < 0.001). In addition, high-lycopene tomato intake improved LDL-C (p = 0.027). The intake of high-lycopene tomato, PR-7, reduced LDL-C and was confirmed to be safe.
Chondroprotective Effects of Genistein against Osteoarthritis Induced Joint Inflammation
Authors: Liu Feng-Cheng , Wang Chih-Chien , Lu Jeng-Wei , Lee Chian-Her , Chen Shao-Chi , Ho Yi-Jung , Peng Yi-Jen
Published: May 2019

Genistein is an isoflavone extracted from soybean (Glycine max). This compound has anti-inflammatory, anti-oxidative, and anti-cancer effects; however, the mechanism underlying the effects of genistein on IL-1β-stimulated human osteoarthritis (OA) chondrocytes remains unknown. Our objectives in this study were to explore the anti-inflammatory effects of genistein on IL-1β-stimulated human OA chondrocytes and to investigate the potential mechanisms which underlie them. Our results from an in-vitro model of osteoarthritis indicate that genistein inhibits the IL-1β-induced expression of the catabolic factors nitric oxide synthase 2 (NOS2), cyclooxygenase 2 (COX-2), and matrix metalloproteinases (MMPs). Genistein was shown to stimulate Ho-1 expression, which has been associated with Nrf-2 pathway activation in human chondrocytes. In a rat model, genistein was also shown to attenuate the progression of traumatic osteoarthritis. Taken together, these results demonstrate the effectiveness of genistein in mediating the inflammation associated with joint disorders. Our results also indicate that genistein could potentially serve as an alternative therapeutic treatment for OA.
Sulforaphane Prevents Hepatic Insulin Resistance by Blocking Serine Palmitoyltransferase 3-Mediated Ceramide Biosynthesis
Authors: Teng Wendi , Li Yuan , Du Min , Lei Xingen , Xie Siyu , Ren Fazheng
Published: May 2019

Sulforaphane (SFA), a naturally active isothiocyanate compound from cruciferous vegetables used in clinical trials for cancer treatment, was found to possess potency to alleviate insulin resistance. But its underlying molecular mechanisms are still incompletely understood. In this study, we assessed whether SFA could improve insulin sensitivity and glucose homeostasis both in vitro and in vivo by regulating ceramide production. The effects of SFA on glucose metabolism and expression levels of key proteins in the hepatic insulin signaling pathway were evaluated in insulin-resistant human hepatic carcinoma HepG2 cells. The results showed that SFA dose-dependently increased glucose uptake and intracellular glycogen content by regulating the insulin receptor substrate 1 (IRS-1)/protein kinase B (Akt) signaling pathway in insulin-resistant HepG2 cells. SFA also reduced ceramide contents and downregulated transcription of ceramide-related genes. In addition, knockdown of serine palmitoyltransferase 3 (SPTLC3) in HepG2 cells prevented ceramide accumulation and alleviated insulin resistance. Moreover, SFA treatment improved glucose tolerance and insulin sensitivity, inhibited SPTLC3 expression and hepatic ceramide production and reduced hepatic triglyceride content in vivo. We conclude that SFA recovers glucose homeostasis and improves insulin sensitivity by blocking ceramide biosynthesis through modulating SPTLC3, indicating that SFA may be a potential candidate for prevention and amelioration of hepatic insulin resistance via a ceramide-dependent mechanism.
Effect of Vitamin D3 on the Postprandial Lipid Profile in Obese Patients: A Non-Targeted Lipidomics Study
Authors: Fernández-Arroyo Salvador , Hernández-Aguilera Anna , de Vries Marijke A. , Burggraaf Benjamin , van der Zwan Ellen , Pouw Nadine , Joven Jorge , Castro Cabezas Manuel
Published: May 2019

Postprandial lipemia can lead to an accumulation of atherogenic lipoproteins in the circulation associated with systemic low-grade inflammation and an increased risk of cardiovascular disease. Lifestyle and pharmacological treatments are usually prescribed for prevention. Vitamin D3 (cholecalciferol), as an anti-atherogenic agent, is being taken into consideration due to its potential beneficial effects in lipid metabolism and its anti-inflammatory potency. To assess the effects of vitamin D3 in the postprandial lipid profile in obese, vitamin D-deficient women, a non-targeted lipidomics approach using liquid chromatography coupled to a quadrupole time-of flight mass spectrometer was used to identify and quantitate a wide-range of circulating lipid species, including diglycerides, lysophosphatidylcholines, phosphatidylcholines, phosphatidylethanolamines, sphingomyelins and triglycerides. The most important changes were found in plasmatic sphingomyelin levels, which experience a decrease after vitamin D3 intake. Our results suggest a turnover of sphingomyelins, probably due to an increased activity of neutral sphingomyelinases, and, therefore, with implications in the clearance of chylomicrons, LDL and VLDL, decreasing postprandial inflammation and macrophage adherence to endothelia, potentially improving cardiovascular disease risk.
Animal Virus Ecology and Evolution Are Shaped by the Virus Host-Body Infiltration and Colonization Pattern
Authors: Slingenbergh Jan
Published: May 2019

The current classification of animal viruses is largely based on the virus molecular world. Less attention is given to why and how virus fitness results from the success of virus transmission. Virus transmission reflects the infection-shedding-transmission dynamics, and with it, the organ system involvement and other, macroscopic dimensions of the host environment. This study describes the transmission ecology of the world main livestock viruses, 36 in total, a mix of RNA, DNA and retroviruses. Following an iterative process, the viruses are virtually ranked in an outer- to inner-body fashion, by organ system, on ecological grounds. Also portrayed are the shifts in virus host tropism and virus genome. The synthesis of the findings reveals a predictive virus evolution framework, based on the outer- to inner-body changes in the interplay of host environment-transmission modes-organ system involvement-host cell infection cycle-virus genome. Outer-body viruses opportunistically respond to the variation in the external environment. For example, respiratory and enteric viruses tend to be associated with poultry and pig mass rearing. Ruminant and equine viruses tend to be more deep-rooted and host-specific, and also establish themselves in the vital inner-body systems. It is concluded that the framework may assist the study of new emerging viruses and pandemic risks.
Drug Delivery Technology to the CNS in the Treatment of Brain Tumors: The Sherbrooke Experience
Authors: Fortin David
Published: May 2019

Drug delivery to the central nervous system (CNS) remains a challenge in neuro-oncology. Despite decades of research in this field, no consensus has emerged as to the best approach to tackle this physiological limitation. Moreover, the relevance of doing so is still sometimes questioned in the community. In this paper, we present our experience with CNS delivery strategies that have been developed in the laboratory and have made their way to the clinic in a continuum of translational research. Using the intra-arterial (IA) route as an avenue to deliver chemotherapeutics in the treatment of brain tumors, complemented by an osmotic breach of the blood-brain barrier (BBB) in specific situations, we have developed over the years a comprehensive research effort on this specialized topic. Looking at pre-clinical work supporting the rationale for this approach, and presenting results discussing the safety of the strategy, as well as results obtained in the treatment of malignant gliomas and primary CNS lymphomas, this paper intends to comprehensively summarize our work in this field.
Application of Loop-Mediated Isothermal Amplification in an Early Warning System for Epidemics of an Externally Sourced Plant Virus
Authors: Congdon Benjamin , Matson Paul , Begum Farhana , Kehoe Monica , Coutts Brenda
Published: May 2019

Restricting Turnip yellows virus (TuYV) spread in canola (Brassica napus) crops often relies upon the application of systemic insecticides to protect young vulnerable plants from wide-scale green-peach aphid (GPA; Myzus persicae) colonization and subsequent virus infection. For these to be applied at the optimal time to ensure they prevent epidemics, growers would need to be forewarned of incoming viruliferous aphid migration and colonization. This study was conducted to field validate a loop-mediated isothermal amplification (LAMP) protocol designed to detect TuYV in aphids caught on traps and develop an early warning system for TuYV epidemics. Double-sided yellow sticky traps were deployed at 30 sites sown with canola over a two-year period in the south-west Australian grainbelt. Using LAMP, the percentage (%) of trap sides with TuYV-carrying aphids was measured and related to TuYV infection incidence in the adjacent crop. When TuYV was detected in aphids on >30% trap sides in a six-week period from pre-emergence to GS15 (five-leaf stage), TuYV reached >60% crop incidence by GS30 (beginning of stem elongation). Whereas, TuYV detection in aphids on ≤15% trap sides during this period was associated with ≤6% TuYV incidence by GS30. Furthermore, when large numbers of aphids, including GPA, were caught during this period but no TuYV was detected in them, minimal TuYV spread (≤5%) occurred in the crop by GS30. Therefore, the LAMP TuYV protocol can be used in an early warning system for TuYV epidemics by providing detection of initial viruliferous aphid migration into a canola crop before they establish colonies throughout the crop and spread virus. This would enable proactive, non-prophylactic, and thereby more effective systemic insecticide applications to minimize seed yield and quality losses due to early season TuYV infection.
Active Role of ZnO Nanorods in Thermomechanical and Barrier Performance of Poly(vinyl alcohol-co-ethylene) Formulations for Flexible Packaging
Authors: Luzi Francesca , Di Michele Alessandro , Torre Luigi , Puglia Debora
Published: May 2019

Poly(vinyl alcohol-co-ethylene) (EVOH) films containing zinc oxide nanorods (ZnO Nrods) at 0.1, 0.5, and 1 wt%, were realized by solvent casting. The effect of ZnO Nrods content on morphological, thermal, optical, mechanical, and oxygen permeability properties were analyzed. In addition, moisture content and accelerated-aging test studies were performed, with the intention to determine the influence of zinc oxide nanofillers on the functional characteristics of realized packaging systems. Tensile properties showed increased values for strength and deformation-at-break in EVOH-based formulations reinforced with 0.1 and 0.5 wt% of zinc oxide nanorods. Results from the colorimetric and transparency investigations underlined that the presence of ZnO Nrods in EVOH copolymer did not induce evident alterations. In addition, after the accelerated-aging test, the colorimetric test confirmed the possibility for these materials to be used in the packaging sector. This behavior was induced by the presence of zinc oxide nanofillers that act as a UV block that made them useful as an efficient absorber of UV radiation.
Biosourced Disposable Trays Made of Brewer’s Spent Grain and Potato Starch
Authors: Ferreira Ana M. , Martins Jorge , Carvalho Luísa H. , Magalhães Fernão D.
Published: May 2019

Single-use plastic items made of non-biodegradable and fossil-based materials have been identified as a major environmental problem in modern society. Food packaging materials represent an important fraction of these, and replacement with biosourced, sustainable and low-cost alternatives, is a key priority. In the present work, and for the first time, trays suitable for some food packaging applications were produced by the hot-pressing of brewer’s spent grains (BSG, a low added-value byproduct of the beer industry), bound with potato starch. Expanded polystyrene (EPS) trays were used as reference, since this material has been widely used in food packaging trays. The results demonstrated that all trays produced with varying proportions of BSG and potato starch have appropriate flexural strength, with values ranging between 1.51 ± 0.32 MPa, for 80% BSG content, and 2.62 ± 0.46 MPa, for 40% BSG content, which is higher than for EPS, 0.64 ± 0.50 MPa. Regardless of BSG content, flexural strength and modulus decreased significantly after contact with water, due to starch plasticization, attaining values below EPS. Trays produced with 60% BSG, and also with the addition of chitosan and glyoxal presented the highest flexural strength, both before and after contact with water, 3.75 ± 0.52 MPa and 0.44 ± 0.11 MPa, respectively. The latter is reasonably close to the reference value obtained for EPS.
Effect of Irradiation and Detection of Long-Lived Polyenyl Radicals in Highly Crystalline Ultra-High Molar Mass Polyethylene (UHMMPE) Fibers
Authors: Forster Amanda L. , Tsinas Zois , Al-Sheikhly Mohamad
Published: May 2019

To improve properties such as thermal conductivity, low temperature thermal strain, and creep resistance of ultra-high molar mass polyethylene (UHMMPE) fibers, several researchers have previously undertaken efforts to crosslink these fibers using radiation. Ionizing radiation is commonly used to crosslink bulk UHMMPE in other applications, such as artificial joints. However, UHMMPE fibers differ from bulk UHMMPE in that they have a higher crystallinity (approximately 85% to 90%) and are very highly oriented during manufacturing in which the fibers are stretched 50 to 100 times their original length. Thus, the amorphous fraction of the UHMMPE fibers is also highly ordered. Several experiments were conducted to crosslink the UHMMPE fibers using both low dose rate (gamma) and high dose rate (electron beam) irradiation, all in the absence of oxygen. In all cases, the tensile strength of the fiber was greatly reduced by the irradiation. The oxidation index was also measured for the irradiated samples, and oxidation was not found to play a major role in the reduction of tensile strength in the fibers after irradiation. While this work did not achieve the desired result of improving the mechanical properties of the UHMMPE fiber, a significant result was found. The electron paramagnetic resonance (EPR) spectrum of the UHMMPE fibers was measured shortly after irradiation, and a mixture of allyl and alkyl radicals were detected. The irradiated samples were stored in dark ambient conditions for at least six years, then reexamined using EPR for free radical characterization. Surprisingly, the gamma-irradiated samples showed clear evidence of long-lived polyenyl radicals present in the material. Free radicals are very reactive species that will typically migrate to the surface of the crystalline domain and decay in a relatively short time through various reactions in the amorphous regions. It is hypothesized herein that due to the high crystallinity and large anisotropy of the highly drawn UHMMPE fiber, the polyenyl radicals were trapped in the crystal phase and were unable to migrate and decay. An experiment was performed to test this hypothesis, by which samples of the irradiated fibers were heated to temperatures above first the alpha relaxation and then melting point of polyethylene, and EPR measurements were taken. Results showed that the polyenyl radical signal persisted below the Tm, but was rapidly eliminated upon melting of the crystals. These experiments support the hypothesis that the long-lived polyenyl radicals are trapped in the crystalline region of the polyethylene fibers.
Varve Distribution Reveals Spatiotemporal Hypolimnetic Hypoxia Oscillations During the Past 200 Years in Lake Lehmilampi, Eastern Finland
Authors: Salminen Sarianna , Saarni Saija , Tammelin Mira , Fukumoto Yu , Saarinen Timo
Published: May 2019

We investigated 34 sediment cores to reconstruct spatiotemporal variations in hypolimnetic hypoxia for the past 200 years in Lehmilampi, a small lake in Eastern Finland. As hypoxia is essential for varve preservation, spatiotemporal changes in varve distribution were used as an indicator for hypolimnetic hypoxia oscillations. The hypoxic water volume was used as a variable reflecting hypolimnetic hypoxia and determined for each year by estimating the water volume beneath the water depth where shallowest varves were preserved. As a result, seven hypoxia periods, highlighting the variations in hypolimnetic hypoxia, are established. These periods may be influenced by bioturbation, lake infill, and lake level changes. Furthermore, we evaluated the relationship between hypolimnetic hypoxia oscillations and climatic factors. Diatom assemblage changes were also analyzed to estimate whether the hypoxia periods could be related to anthropogenic eutrophication. The diatom analyses suggest relatively stable nutrient conditions for the past 200 years in Lake Lehmilampi. Climate, on the other hand, seems to be an important driver of hypoxia oscillations based on correlation analysis. The role of individual forcing factors and their interaction with hypolimnetic hypoxia would benefit from further investigations. Understanding climatic and anthropogenic forcing behind hypolimnetic hypoxia oscillations is essential when assessing the fate of boreal lakes in a multi-stressor world.
A Moderate Millenarianism: Apocalypticism in the Church of Jesus Christ of Latter-Day Saints
Authors: Spencer Joseph M.
Published: May 2019

The Church of Jesus Christ of Latter-Day Saints, the largest and arguably best-known branch of the Restoration movement begun by Joseph Smith, sustains a complex but living relationship to nineteenth-century marginal millenarianism and apocalypticism. At the foundations of this relationship is a consistent interest in the biblical Book of Revelation exhibited in the earliest Latter-Day Saint scriptural texts. The Book of Mormon (1830) affirms that apocalyptic visionary experiences like John’s in the New Testament have occurred throughout history and even contains a truncated account of such a vision. It also predicts the emergence in late modernity of a fuller and uncorrupted account of such an apocalyptic vision, with the aim of clarifying the biblical Book of Revelation. In addition, however, Smith received an apocalyptic vision of his own in 1832 and produced a vision report that suggests that he understood The Book of Mormon’s anticipations of apocalyptic clarification to come as much through ecstatic experience as through the emergence of new apocalyptic texts. In 1842, Smith created a ritualized version of his own apocalyptic experience, a temple liturgy that remains authoritative into the present. This lies behind the moderate apocalypticism of twenty-first century Latter-Day Saint religious experience.
Transformational Ethics: The Concept of Obedience in Post-Conciliar Jesuit Thinking
Authors: Schnoor Antje
Published: May 2019

The paper sheds light on the change in the concept of obedience within the Society of Jesus since the 1960s. In the aftermath of the Second Vatican Council, a so-called crisis of authority and obedience took place in the Catholic Church and the religious orders. As a consequence, the notions of responsibility and conscience came to the fore in the Jesuit definition of obedience. The religious concept of obedience, that is the obedience towards God, was reassessed as a service to humanity. The paper analyzes how the change in the concept of obedience gave rise to the promotion of social justice, which the Society of Jesus proclaimed at General Congregation 32 in 1974/75. By including the promotion of social justice into their central mission, Jesuits not only fundamentally transformed their self-conception, but also their ethical values. The paper argues that the pursuit of social justice became a form of religious obedience.
The Lion and the Wisdom—The Multiple Meanings of the Lion as One of the Keys for Deciphering Vittore Carpaccio’s Meditation on the Passion
Authors: Moscovich Atara
Published: May 2019

The current paper will concentrate on the lion featured in Vittore Carpaccio’s Meditation on the Passion. The multiple meanings of the lion in primary sources will serve as a key towards demonstrating the concept of prophecy, one of the multi-level meanings referring to all three figures featured in the painting—Job, Christ and St. Jerome. To this, an interpretation not discussed hitherto with reference to the Meditation will be added—the lion as alluding to the concept of wisdom as referred to in the book of Job. Furthermore, the lion and the wisdom will be discussed as an allusion to the self-image of Venice during the period in which the painting was executed, and thus add another, social and civic, reading.
Comparison of Normalized Difference Vegetation Index Derived from Landsat, MODIS, and AVHRR for the Mesopotamian Marshes Between 2002 and 2018
Authors: Albarakat Reyadh , Lakshmi Venkataraman
Published: May 2019

The Mesopotamian marshes are a group of water bodies located in southern Iraq, in the shape of a triangle, with the cities Amarah, Nasiriyah, and Basra located at its corners. The marshes are appropriate habitats for a variety of birds and most of the commercial fisheries in the region. The normalized difference vegetation index (NDVI) has been derived using observations from various satellite sensors, such as the Moderate Resolution Imaging Spectroradiometer (MODIS), Advanced Very-High-Resolution Radiometer (AVHRR), and Landsat over the Mesopotamian marshlands for the 17-year period between 2002 and 2018. We have chosen this time series (2002–2018) to monitor the change in vegetation of the study area since it is considered as a period of rehabilitation for the marshes (following a period when there was little to no water flowing into the marshes). Statistical analyses were performed to monitor the variability of the maximum biomass time (month of June). The results illustrated a strong positive correlation between the NDVI derived from Landsat, MODIS, and AVHRR. The statistical correlations were 0.79, 0.77, and 0.96 between Landsat and AVHRR, MODIS and AVHRR, and Landsat and MODIS, respectively. The linear slope of NDVI (Landsat, MODIS, and AVHRR) for each pixel over the period 2002–2018 displays a long-term trend of green biomass (NDVI) change in the study area, and the slope is slightly negative over most of the area. Slope values (−0.002 to −0.05) denote a slight decrease in the observed vegetation index over 17 years. The green biomass of the marshlands increased by 33.2% of the total area over 17 years. The areas of negative and positive slopes correspond to the same areas in slope map when calculated from Landsat, MODIS, and AVHRR, although they are different in spatial resolution (30 m, 1 km, and 5 km, respectively). The time series of the average NDVI (2002–2018) for three different sensors shows the highest and lowest NDVI values during the same years (for the month of June each year). The highest values were 0.19, 0.22, and 0.22 for Landsat, MODIS, and AVHRR, respectively, in 2006, and the lowest values were 0.09, 0.14, and 0.09 for Landsat, MODIS, and AVHRR, respectively, in 2003.
Higher-Order Conditional Random Fields-Based 3D Semantic Labeling of Airborne Laser-Scanning Point Clouds
Authors: Li Yong , Chen Dong , Du Xiance , Xia Shaobo , Wang Yuliang , Xu Sheng , Yang Qiang
Published: May 2019

This paper presents a novel framework to achieve 3D semantic labeling of objects (e.g., trees, buildings, and vehicles) from airborne laser-scanning point clouds. To this end, we propose a framework which consists of hierarchical clustering and higher-order conditional random fields (CRF) labeling. In the hierarchical clustering, the raw point clouds are over-segmented into a set of fine-grained clusters by integrating the point density clustering and the classic K-means clustering algorithm, followed by the proposed probability density clustering algorithm. Through this process, we not only obtain a more uniform size and more homogeneous clusters with semantic consistency, but the topological relationships of the cluster’s neighborhood are implicitly maintained by turning the problem of topology maintenance into a clustering problem based on the proposed probability density clustering algorithm. Subsequently, the fine-grained clusters and their topological context are fed into the CRF labeling step, from which the fine-grained cluster’s semantic labels are learned and determined by solving a multi-label energy minimization formulation, which simultaneously considers the unary, pairwise, and higher-order potentials. Our experiments of classifying urban and residential scenes demonstrate that the proposed approach reaches 88.5% and 86.1% of “m F 1 ” estimated by averaging all classes of the F 1 -scores. We prove that the proposed method outperforms five other state-of-the-art methods. In addition, we demonstrate the effectiveness of the proposed energy terms by using an “ablation study” strategy.
Net Cloud Thinning, Low-Level Cloud Diminishment, and Hadley Circulation Weakening of Precipitating Clouds with Tropical West Pacific SST Using MISR and Other Satellite and Reanalysis Data
Authors: Kubar Terence L. , Jiang Jonathan H.
Published: May 2019

Daily gridded Multi-Angle Imaging Spectroradiometer (MISR) satellite data are used in conjunction with CERES, TRMM, and ERA-Interim reanalysis data to investigate horizontal and vertical high cloud structure, top-of-atmosphere (TOA) net cloud forcing and albedo, and dynamics relationships against local SST and precipitation as a function of the mean Tropical West Pacific (TWP; 120°E to 155°W; 30°S–30°N) SST. As the TWP warms, the SST mode (~29.5 °C) is constant, but the area of the mode grows, indicating increased kurtosis of SSTs and decreased SST gradients overall. This is associated with weaker low-level convergence and mid-tropospheric ascent (ω500) over the highest SSTs as the TWP warms, but also a broader area of weak ascent away from the deepest convection, albeit stronger when compared to when the mean TWP is cooler. These associated dynamics changes are collocated with less anvil and thick cloud cover over the highest SSTs and similar thin cold cloud fraction when the TWP is warmer, but broadly more anvil and cirrus clouds over lower local SSTs (SST < 27 °C). For all TWP SST quintiles, anvil cloud fraction, defined as clouds with tops > 9 km and TOA albedos between 0.3–0.6, is closely associated with rain rate, making it an excellent proxy for precipitation; but for a given heavier rain rate, cirrus clouds are more abundant with increasing domain-mean TWP SST. Clouds locally over SSTs between 29–30 °C have a much less negative net cloud forcing, up to 25 W m−2 greater, when the TWP is warm versus cool. When the local rain rate increases, while the net cloud fraction with tops < 9 km decreases, mid-level clouds (4 km < Ztop < 9 km) modestly increase. In contrast, combined low-level and mid-level clouds decrease as the domain-wide SST increases (−10% deg−1). More cirrus clouds for heavily precipitating systems exert a stronger positive TOA effect when the TWP is warmer, and anvil clouds over a higher TWP SST are less reflective and have a weaker cooling effect. For all precipitating systems, total high cloud cover increases modestly with higher TWP SST quintiles, and anvil + cirrus clouds are more expansive, suggesting more detrainment when TWP SSTs are higher. Total-domain anvil cloud fraction scales mostly with domain-mean ω500, but cirrus clouds mostly increase with domain-mean SST, invoking an explanation other than circulation. The overall thinning and greater top-heaviness of clouds over the TWP with warming are possible TWP positive feedbacks not previously identified.
Influence of Drone Altitude, Image Overlap, and Optical Sensor Resolution on Multi-View Reconstruction of Forest Images
Authors: Seifert Erich , Seifert Stefan , Vogt Holger , Drew David , van Aardt Jan , Kunneke Anton , Seifert Thomas
Published: May 2019

Recent technical advances in drones make them increasingly relevant and important tools for forest measurements. However, information on how to optimally set flight parameters and choose sensor resolution is lagging behind the technical developments. Our study aims to address this gap, exploring the effects of drone flight parameters (altitude, image overlap, and sensor resolution) on image reconstruction and successful 3D point extraction. This study was conducted using video footage obtained from flights at several altitudes, sampled for images at varying frequencies to obtain forward overlap ratios ranging between 91 and 99%. Artificial reduction of image resolution was used to simulate sensor resolutions between 0.3 and 8.3 Megapixels (Mpx). The resulting data matrix was analysed using commercial multi-view reconstruction (MVG) software to understand the effects of drone variables on (1) reconstruction detail and precision, (2) flight times of the drone, and (3) reconstruction times during data processing. The correlations between variables were statistically analysed with a multivariate generalised additive model (GAM), based on a tensor spline smoother to construct response surfaces. Flight time was linearly related to altitude, while processing time was mainly influenced by altitude and forward overlap, which in turn changed the number of images processed. Low flight altitudes yielded the highest reconstruction details and best precision, particularly in combination with high image overlaps. Interestingly, this effect was nonlinear and not directly related to increased sensor resolution at higher altitudes. We suggest that image geometry and high image frequency enable the MVG algorithm to identify more points on the silhouettes of tree crowns. Our results are some of the first estimates of reasonable value ranges for flight parameter selection for forestry applications.
Data Processing and Interpretation of Antarctic Ice-Penetrating Radar Based on Variational Mode Decomposition
Authors: Cheng Siyuan , Liu Sixin , Guo Jingxue , Luo Kun , Zhang Ling , Tang Xueyuan
Published: May 2019

In the Arctic and Antarctic scientific expeditions, ice-penetrating radar is an effective method for studying the bedrock under the ice sheet and ice information within the ice sheet. Because of the low conductivity of ice and the relatively uniform composition of ice sheets in the polar regions, ice-penetrating radar is able to obtain deeper and more abundant data than other geophysical methods. However, it is still necessary to suppress the noise in radar data to obtain more accurate and plentiful effective information. In this paper, the entirely non-recursive Variational Mode Decomposition (VMD) is applied to the data noise reduction of ice-penetrating radar. VMD is a decomposition method of adaptive and quasi-orthogonal signals, which decomposes airborne radar data into multiple frequency-limited quasi-orthogonal Intrinsic Mode Functions (IMFs). The IMFs containing noise are then removed according to the information distribution in the IMF’s components and the remaining IMFs are reconstructed. This paper employs this method to process the real ice-penetrating radar data, which effectively eliminates the interference noise in the data, improves the signal-to-noise ratio and obtains the clearer inner layer structure of ice. It is verified that the method can be applied to the noise reduction processing of polar ice-penetrating radar data very well, which provides a better basis for data interpretation. At last, we present fine ice structure within the ice sheet based on VMD denoised radar profile.
Analysis of Factors Affecting Asynchronous RTK Positioning with GNSS Signals
Authors: Shu Bao , Liu Hui , Feng Yanming , Xu Longwei , Qian Chuang , Yang Zhixin
Published: May 2019

For short baseline real-time kinematic (RTK) positioning, the atmosphere and broadcast ephemeris errors can be usually eliminated in double-differenced (DD) processing for synchronous observations. However, in the case of possible communication latency time, these errors may not be eliminated in DD treatments due to their variations during latency time. In addition, the time variation of these errors may present different characteristics among GPS, GLONASS, BDS, and GALILEO due to different satellite orbit and clock types. In this contribution, the formulas for studying the broadcast orbit and clock offset errors and atmosphere error in asynchronous RTK (ARTK) model is proposed, and comprehensive experimental analysis is performed to numerically show time variations of these errors and their impacts on RTK results from short-baselines among four systems. Compared with synchronous RTK, the degradation of position precision for ARTK can reach a few centimeters, but the accuracy degradation to a different degree by different systems. BDS and Galileo usually outperform GPS and GLONASS in ARTK due to the smaller variation of broadcast ephemeris error. The variation of broadcast orbit error is generally negligible compared with the variation of broadcast clock offset error for GPS, BDS, and Galileo. Specifically, for a month of data, the root mean square (RMS) values for the variation of broadcast ephemeris error over 15 seconds are 11.2, 16.9, 7.3, and 3.0 mm for GPS, GLONASS, BDS, and Galileo, respectively. The variation of ionosphere error for some satellites over 15 seconds can reach a few centimeters during active sessions under a normal ionosphere day. In addition, compared with other systems, BDS ARTK shows an advantage under high ionosphere activity, and such advantage may be attributed to five GEO satellites in the BDS constellation.
Machine Learning Techniques for Chemical Identification Using Cyclic Square Wave Voltammetry
Authors: Dean Scott N. , Shriver-Lake Lisa C. , Stenger David A. , Erickson Jeffrey S. , Golden Joel P. , Trammell Scott A.
Published: May 2019

Electroanalytical techniques are useful for detection and identification because the instrumentation is simple and can support a wide variety of assays. One example is cyclic square wave voltammetry (CSWV), a practical detection technique for different classes of compounds including explosives, herbicides/pesticides, industrial compounds, and heavy metals. A key barrier to the widespread application of CSWV for chemical identification is the necessity of a high performance, generalizable classification algorithm. Here, machine and deep learning models were developed for classifying samples based on voltammograms alone. The highest performing models were Long Short-Term Memory (LSTM) and Fully Convolutional Networks (FCNs), depending on the dataset against which performance was assessed. When compared to other algorithms, previously used for classification of CSWV and other similar data, our LSTM and FCN-based neural networks achieve higher sensitivity and specificity with the area under the curve values from receiver operating characteristic (ROC) analyses greater than 0.99 for several datasets. Class activation maps were paired with CSWV scans to assist in understanding the decision-making process of the networks, and their ability to utilize this information was examined. The best-performing models were then successfully applied to new or holdout experimental data. An automated method for processing CSWV data, training machine learning models, and evaluating their prediction performance is described, and the tools generated provide support for the identification of compounds using CSWV from samples in the field.