bluuebunny/crossref_metadata_2025 huggingface dataset:
Differences in Inflorescence Numbers and Endogenous Gibberellic Acid Levels in ‘Afterglow’ Bougainvillea
Authors: Chng Mun Wye , Moore Kimberly A.
Published: September 2020

Bougainvillea (Bougainvillea sp.) plant inflorescence number will vary in response to multiple cues such as changes in temperature, water, light intensity, pruning, and photoperiod. Previous research reports that the application of plant growth regulators (PGRs) to bougainvillea grown under varying photoperiods improved inflorescence number, probably as a result of changes in gibberellic acid (GA) levels. There are many bioactive plant GAs, but we chose to investigate differences in gibberellic acid 3 (GA3) levels and inflorescence number in response to the application of ethephon (2-cholorethylphosponic acid) or abscisic acid (ABA) to ‘Afterglow’ bougainvillea (Bougainvillea ×buttiana) grown under 14-hour photoperiod [long-day (LD)] conditions. Plants were 5 inches tall with seven visible lateral nodes and were grown in a greenhouse in 4-inch pots filled with 5-mm coarse aquarium zeolite. Ethephon was applied as a foliar spray at 0.05, 0.07, 0.10, 0.15, or 0.20 mg/plant. ABA was applied as a soil drench at 1, 1.5, 3, 6, 8, or 10 mg/plant. Endogenous levels of GA3 were measured 1 and 48 days after treatment to calculate the change in GA3 (∆GA3). A short day (SD) control of 8 hours was included to measure differences in inflorescence number and ∆GA3 between photoperiods. ‘Afterglow’ plants grown under SD conditions had the greatest decrease in ∆GA3 (–1.09 µg·g–1) over 48 days and the most inflorescences (10.6) compared with LD control plants with a decrease in ∆GA3 of –0.09 µg·g–1 and fewer inflorescences (1.0). Plants grown under LD conditions and treated with 0.05 mg/plant ethephon had inflorescence numbers (9.6) and levels of ∆GA3 (–0.74 µg·g–1) similar to the SD control. As ethephon rate increased to more than 0.05 mg/plant, inflorescence number on LD plants decreased and ∆GA3 increased. Exogenous ABA rates of 1 mg/plant produced inflorescence numbers (1.4) and ∆GA3 (–0.10 µg·g–1) similar to the LD control. As the rate increased, ∆GA3 increased and inflorescence number decreased. Plants treated with ABA rates of 3 mg/plant and more were defoliated and had no inflorescences.
CONTEXTUALISING ISLAMIC LAWS
Authors: Dahlan Moh.
Published: September 2020

This paper by using the ijtihad paradigm of maqâshid al-syarî’ah of Jasser Audah and the descriptive-analytical approach, would like to emphasize that the role of religion and economic welfare are two things that cannot be separated. Although in practice these two things often face obstacles, especially in the matter of diversity in religious life because of the superficial ijtihad paradigm of Islamic law. Based on the contemporary paradigm that seeks to provide new criteria in the conception of qath’i al-dlilalah and dlanni al-dlilalah, it can be stated that the contemporary Islamic law paradigm that needs to be built must be based on (a) the development of citizens’ welfare Muslims, but also must be the same as non-Muslims because of that we need to carry out financial and economic reforms (al-ishlâh al-mâlî wa al-iqtishâdî); (b) protection of freedom of thought (hurriyah al-tafkîr) and freedom of religion (hurriyah al-i’tiqâd) is an important aspect that must be maintained to guarantee the peace and harmony of the nation’s life in the territory of Indonesia. Therefore, the religious and economic aspects must be prioritized for their protection and safety.
Exploring Multiple Sclerosis (MS) and Amyotrophic Lateral Scler osis (ALS) as Neurodegenerative Diseases and their Treatments: A Review Study
Authors: Deeb Omar , Nabulsi Maisa
Published: September 2020

:

Growing concern about neurodegenerative diseases is becoming a global issue. It is estimated
that not only will their prevalence increase but also morbidity and health burden will be concerning. Scientists,
researchers and clinicians share the responsibility of raising the awareness and knowledge about
the restricting and handicapping health restrains related to these diseases.

:

Multiple Sclerosis (MS), as one of the prevalent autoimmune diseases, is characterized by abnormal
regulation of the immune system that periodically attacks parts of the nervous system; brain and spinal
cord. Symptoms and impairments include weakness, numbness, visual problems, tingling pain that are
quietly variable among patients.

:

Amyotrophic Lateral Sclerosis (ALS) is another neurodegenerative disease that is characterized by the
degeneration of motor neurons in the brain and spinal cord. Unlike MS, symptoms begin with muscle
weakness and progress to affect speech, swallowing and finally breathing. Despite the major differences
between MS and ALS, misdiagnosis is still influencing disease prognosis and patient’s quality of life.

:

Diagnosis depends on obtaining a careful history and neurological examination as well as the use of
Magnetic Resonance Imaging (MRI), which are considered challenging and depend on the current disease
status in individuals.

:

Fortunately, a myriad of treatments is available now for MS. Most of the cases are steroid responsive.
Disease modifying therapy is amongst the most important set of treatments.

:

In ALS, few medications that slow down disease progression are present. The aim of this paper is to
summarize what has been globally known and practiced about MS and ALS, as they are currently classified
as important growing key players among autoimmune diseases. In terms of treatments, it is concluded
that special efforts and input should be directed towards repurposing of older drugs and on stem
cells trials. As for ALS, it is highlighted that supportive measurements and supplementary treatments
remain essentially needed for ALS patients and their families. On the other hand, it is noteworthy to
clarify that the patient-doctor communication is relatively a cornerstone in selecting the best treatment
for each MS patient.
Advances in Synthesis, Derivatization and Bioactivity of Isatin: A Review
Authors: Chauhan Garima , Pathak Dharam Pal , Ali Faraat , Bhutani Rubina , Kapoor Garima , Khasimbi Shaik
Published: September 2020

Background:

Isatin (IST) is a crucial pharmacologically active compound, chemically known as indole-
1H-2,3-dione. Development of different IST based analogues acquired significant awareness because of its
pronounced therapeutic importance such as analgesic, anticancer, anti-inflammatory, antitubercular, antimicrobial,
antifungal, antiviral (effective against SARS coronavirus 3C protease) and many other activities, and represents
an important class of heterocyclic compounds that can be used as a precursor for the synthesis of many useful
drugs.

Objective:

Previously, many articles were reported on IST synthesis and its different pharmacological activities
but herein, we mentioned 59 different synthesis schemes of several IST derivatives/hybrids derived from the substitution
of the nitrogen, aromatic ring, the second and third position of IST along with most potent molecule
among each of synthesized libraries with their structural activity relationship (SAR). Using these standardized
approaches, several biologically important compounds were developed like sunitinib, nintedanib, indirubin, etc
and several studies have been carried out nowadays to develop newer compounds having fewer side effects and
also overcome the problem of resistance.

Conclusion:

This report critically reviews the different strategies for the designs and synthesis of several IST
based compounds having different biological activities with SAR, which can favour further investigation and
modification for the development of new and more potent entities.
Pyranoid Spirosugars as Enzyme Inhibitors
Authors: La Ferla Barbara , D’Orazio Giuseppe
Published: September 2020

Background:

Pyranoid spirofused sugar derivatives represent a class of compounds with a significant
impact in the literature. From the structural point of view, the rigidity inferred by the spirofused entity has made
these compounds object of interest mainly as enzymatic inhibitors, in particular, carbohydrate processing enzymes.
Among them glycogen phosphorylase and sodium glucose co-transporter 2 are important target enzymes
for diverse pathological states. Most of the developed compounds present the spirofused entity at the C1 position
of the sugar moiety; nevertheless, spirofused entities can also be found at other sugar ring positions. The main
spirofused entities encountered are spiroacetals/thioacetals, spiro-hydantoin and derivatives, spiro-isoxazolines,
spiro-aminals, spiro-lactams, spiro-oxathiazole and spiro-oxazinanone, but also others are present.

Objectives:

The present review focuses on the most explored synthetic strategies for the preparation of this class
of compounds, classified according to the position and structure of the spirofused moiety on the pyranoid scaffold.
Moreover, the structures are correlated to their main biological activities or to their role as chiral auxiliaries.

Conclusion:

It is clear from the review that, among the different derivatives, the spirofused structures at position
C1 of the pyranoid scaffold are the most represented and possess the most relevant enzymatic inhibitor activities.
Nevertheless, great efforts have been devoted to the introduction of the spirofused entity also in the other positions,
mainly for the preparation of biologically active compounds but also for the synthesis of chiral auxiliaries
useful in asymmetric reactions; examples of such auxiliaries are the spirofused chiral 1,3-oxazolidin-2-ones and
1,3-oxazolidine-2-thiones.
Clinical and In Silico Outcomes of the Expression of miR-130a-5p and miR-615-3p in Tumor Compared with Non-Tumor Adjacent Tissues of Patients with BC
Authors: Ilkhani Khandan , Delgir Soheila , Safi Asma , Seif Farhad , Samei Azam , Bastami Milad , Alivand Mohammad Reza
Published: September 2020

Background:

Breast Cancer (BC) is the most common malignancy among women with a high mortality
rate. The blockade of asparagine-related pathways may be an effective measure to control the progression
and reduction of BC metastasis potential. Recently, it has been shown that various miRNAs, as part of small
non-coding RNAs, have a great role in cancer development, especially asparagine-related pathways, to modulate
the invasiveness.

Objective:

This study aimed to evaluate the expression of miR-130a-5p and miR-615-3p in tumoral and nontumoral
adjacent tissues of patients with BC.

Methods:

There is a chance that asparagine metabolism is influenced by miR-130a-5p and miR-615-3p as confirmed
by bioinformatics analysis. Hence, real-time PCR was conducted on eighty BC tumoral and non-tumoral
adjacent tissues to evaluate the expression level of the two miRNAs. To predict the potential biological process
and molecular pathways of miR-130a-5p, an in silico analysis was performed.

Results:

This study indicated that miR-130a was downregulated in tumoral tissues compared to non-tumoral
adjacent tissues (P-value= 0.01443 and fold change= -2.5137), while miR-615-3p did not show a significant
difference between the two groups. Furthermore, the subgroup studies did not reveal any significant correlation
between the expression of these two miRNAs and subfactors. Furthermore, in silico studies unraveled several
biological processes related to amino-acid metabolism, as well as pathways related to tumor development such
as Phosphatase and Tensin Homolog (PTEN) and JAK-STAT pathways among miR-130a-5p target genes.

Conclusion:

Our findings indicate that miRNA-130a-5p is downregulated in BC tissues and may play a tumor
suppressor role in patients with BC. Therefore, it may be suggested as a potential diagnostic and therapeutic
target for BC.
Perceptions, Practices, and Challenges of Formative Assessment in Initial Nursing Education
Authors: Lajane Halima , Gouifrane Rachid , Qaisar Rabia , Chemsi Ghizlane , Radid Mohamed
Published: September 2020

Background:

Formative assessment is a pedagogical practice that improves teaching, as well as students' learning. There is a multitude of research demonstrating interest in this practice in the field of education. However, this assessment practice is poorly integrated by teachers despite its great pedagogical potential, in addition to the tensions existing between formative and summative assessment that its implementation is more formal by the institutions.

Objective:

The purpose of this research is to explore, as a first step, how nursing teachers conceptualize formative assessment and how they judge its usefulness in the teaching/learning process. Secondly, the study seeks to identify the main challenges that could influence the practice of formative assessment in the context of nursing education.

Methods:

The study used a descriptive quantitative research design. The target population of the study was composed of nursing teachers (N = 50) from the Higher Institute of Nursing and Health Techniques of Casablanca (ISPITS).

This target population includes all permanent nursing teachers working at the ISPITS of Casablanca, divided into the various existing fields. They are responsible for the initial training and practical supervision of nursing students and health technicians enrolled in the cycles of the professional license.

To meet our research objective, we conducted a survey using a questionnaire with 37 items divided into five dimensions based on William and Thompson's (2007) model of formative assessment.

Results:

The results revealed that, in teachers’ practice, the informal approach to formative assessment takes precedence over formal approaches based on planned assessment tools. In addition, their perception of the usefulness of formative assessment is oriented towards a diagnostic function of students' learning difficulties rather than a function of teaching guidance.

Furthermore, the study showed that the time commitment of formative assessment and the diversity of activities required of teachers might be obstacles to a broader practice of formative assessment.

Conclusion:

This study offers suggestions that may help teachers facilitate and innovate the implementation of formative assessment in the field of nursing. Our research perspective is to demonstrate the effect of formative assessment on student learning outcomes through the implementation of a field experiment in collaboration with nursing teachers.
Soil Unconfined Compressive Strength Prediction Using Random Forest (RF) Machine Learning Model
Authors: Ly Hai-Bang , Thai Pham Binh
Published: September 2020

Aims:

Understanding the mechanical performance and applicability of soils is crucial in geotechnical engineering applications. This study investigated the possibility of application of the Random Forest (RF) algorithm – a popular machine learning method to predict the soil unconfined compressive strength (UCS), which is one of the most important mechanical properties of soils.

Methods:

A total number of 118 samples collected and their tests derived from the laboratorial experiments carried out under the Long Phu 1 power plant project, Vietnam. Data used for modeling includes clay content, moisture content, specific gravity, void ratio, liquid limit and plastic limit as input variables, whereas the target is the UCS. Several assessment criteria were used for evaluating the RF model, namely the correlation coefficient (R), root mean squared error (RMSE) and mean absolute error (MAE).

Results:

The results showed that RF exhibited a strong capability to predict the UCS, with the R value of 0.914 and 0.848 for the training and testing datasets, respectively. Finally, a sensitivity analysis was conducted to reveal the importance of input parameters to the prediction of UCS using RF. The specific gravity was found as the most affecting variable, following by clay content, liquid limit, plastic limit, moisture content and void ratio.

Conclusion:

This study might help in the accurate and quick prediction of the UCS for practice purpose.
Intelligence Prediction of Some Selected Environmental Issues of Blasting: A Review
Authors: Murlidhar Bhatawdekar Ramesh , Armaghani Danial Jahed , Mohamad Edy Tonnizam
Published: September 2020

Background:

Blasting is commonly used for loosening hard rock during excavation for generating the desired rock fragmentation required for optimizing the productivity of downstream operations. The environmental impacts resulting from such blasting operations include the generation of flyrock, ground vibrations, air over pressure (AOp) and rock fragmentation.

Objective:

The purpose of this research is to evaluate the suitability of different computational techniques for the prediction of these environmental effects and to determine the key factors which contribute to each of these effects. This paper also identifies future research needs for the prediction of the environmental effects of blasting operations in hard rock.

Methods:

The various computational techniques utilized by the researchers in predicting blasting environmental issues such as artificial neural network (ANN), fuzzy interface system (FIS), imperialist competitive algorithm (ICA), and particle swarm optimization (PSO), were reviewed.

Results:

The results indicated that ANN, FIS and ANN-ICA were the best models for prediction of flyrock distance. FIS model was the best technique for the prediction of AOp and ground vibration. On the other hand, ANN was found to be the best for the assessment of fragmentation.

Conclusion and Recommendation:

It can be concluded that FIS, ANN-PSO, ANN-ICA models perform better than ANN models for the prediction of environmental issues of blasting using the same database. This paper further discusses how some of these techniques can be implemented by mining engineers and blasting team members at operating mines for predicting blast performance.
Effect of coupled deterioration by chloride and carbonation on chloride ions transport in concrete
Authors: Malheiro Raphaele , Camões Aires , Meira Gibson , Amorim Maria Teresa , Castro-Gomes João
Published: September 2020

Carbonation is one of the factors that can influence the chlorides transport. Despite the combined action of chlorides and carbonation being a reality, there is no consensus on the effect of this coupled deterioration on chloride transport. Accelerated tests were used to simulate this environment. Concrete specimens were cast using 0.60 water/cement ratio and CEM I 42.5R. After curing, half of specimens was submitted to accelerated carbonation test (20ºC, 55% RH and 4% CO2) during 1 and 7 months. The other half was protected with plastic film during the same period. Then, the specimens were submitted to the accelerated chlorides attack using: migration test and immersion test. Finished the immersion test, powder samples were extracted from surface to bulk and analysed to obtain free and total chloride profiles and pH profile. According to migration test results, the carbonation increases chloride transport regardless the test period. According to the immersion test results, there is a decrease in chloride ions transport when the specimens are carbonated for 1 month and a noticeable increase when carbonation period increases to 7 months. The redistribution of pores in carbonated concrete and the difficulty of chlorides binding in carbonated concrete are related to these results.
Análisis de la afectación causada por el deterioro de la malla vial del tramo de la estación de Transmilenio-Escuela Militar de la calzada occidente-oriente
Authors: Rodríguez Cerón Johan Camilo , Valero Hernández Sergio Esteban , Villota Arteaga Javier Alejandro , Vega Octavio , Ruiz Acero Johanna Carolina
Published: September 2020

El deterioro del tramo de la malla vial de la Estación Escuela Militar de Transmilenio (ET-ESMIC) impacta negativamente la infraestructura de la estación, el parque automotor y la población usuaria del Sistema Integrado de Transporte Transmilenio (SITT). En este trabajo se estima el nivel de deterioro de la malla vial del tramo de la et-esmic de acuerdo con la tipología de daños que se evidencian en el tipo de pavimento de la calzada. Para esto se estudia la velocidad de los articulados al transitar en el tramo de la malla vial deteriorada, específicamente en la afectación a las variables de tiempo y comodidad, además se mide el Índice de Rugosidad Internacional (IRI), aplicando métodos que comparativamente permitan obtener la mayor precisión en el resultado de la variable en estudio. Finalmente, con base en los resultados obtenidos se recomienda aplicar el Manual de Pavimentos Flexibles para hacer una inspección debidamente respaldada en los lineamientos del Instituto Nacional de Vías (Invias).
Penerapan IoT untuk Sistem Pemantauan Lampu Penerangan Jalan Umum
Authors: Adam Adam , Muharnis Muharnis , Ariadi Ariadi , Lianda Jefri
Published: September 2020

Penerangan jalan umum (PJU) digunakan untuk menerangi jalan, sehingga pengguna jalan mendukung kenyamanan dan keselamatan dimalam hari. Terdapat keterbatasan sistem pemeriksaan dan pelaporan kerusakaan lampu PJU. Artikel ini membahas penerapan teknologi Internet of Things (IoT) untuk memantau gangguan kerusakan pada lampu PJU. Metode yang digunakan dalam pengembangan sistem pemantauan tersebut yaitu, kajian literatur, analisis kebutuhan, perancangan, pembuatan dan pengujian. Sistem ini dilengkapi dengan sensor ZMPT101B, ACS 712, dan Modul WiFi ESP 8266-01. Sensor ZMPT101B digunakan untuk mengukur nilai tegangan PLN, sedangkan sensor ACS 712 merupakan sensor yang digunakan untuk mengukur arus pada lampu jalan.  ESP8266-01 merupakan modul wifi yang dapat terhubung langsung dengan WiFi dan membuat koneksi TCP/IP sehingga dapat mengirim data dari mikrokontroler Arduino Mega2560 ke internet. Sistem pemantauan lampu PJU ini kemudian dapat diakses menggunakan antarmuka ThingSpeak baik dengan ponsel maupun laptop. Hasil pengujian sensor tegangan menunjukan tingkat akurasi sebesar 96,7%, parameter tegangan dan arus lampu ditampilkan dalam bentuk grafik dan indikator. Hasil tersebut menunjukkan bahwa sistem dapat digunakan untuk memantau kondisi lampu PJU. Hal tersebut dapat dijadikan sebagai dasar pengembangan sistem selanjutnya berbasis sistem cerdas untuk mendukung lampu PJU sesuai SNI dan memiliki efisiensi energi.
Methods of specific laboratory testing of new coronavirus infection
Authors: Perevesentsev O. A. , Cholodnaya T. O. , Samsonov A. E. , Burtsev D. V.
Published: September 2020

The review presents a description of the specific laboratory testing of SARS-CoV-2. The effectiveness of certain types of tests depending on the set medical and epidemiological tasks is shown. The importance of using certain diagnostic methods for mass and rapid testing of patients for a new coronavirus infection, which will speed up their detection, was also noted. The effectiveness of using test systems that can be used in outpatient settings without the presence of a stationary laboratory in a medical facility is shown, which will simplify and increase the throughput of medical institutions that perform SARS-CoV-2 diagnostics. This review will be useful for both medical professionals of laboratory specialties and all clinical doctors who are currently working with a new coronavirus infection.
Proinflammatory cytokines in patients with acute myocardial infarction against the background of chronic obstructive pulmonary disease
Authors: Naumov A. V. , Prokofieva T. V. , Polunina O. S. , Saroyants L. V. , Polunina E. A.
Published: September 2020

Objective: To study and analyze serum levels of interleukins (IL): IL-1β, IL-2 and IL-6 in patients with myocardial infarction and chronic obstructive pulmonary disease.

Materials and methods: In 85 people were examined: 28 patients with myocardial infarction, 37 patients with comorbid pathology (myocardial infarction and chronic obstructive pulmonary disease) and 20 somatically healthy volunteers as a control group. Determination of IL-1β, IL-2 and IL-6 levels was basing on enzyme immunoassay.

Results: The median and inter-percentile range of IL-1β, IL-2 and IL-6 in the donors did not differ significantly from the data of the manufacturer. In the group of patients with myocardial infarction and in patients with comorbid pathology a statistically significant increase in the level of median and inter-percentile range of cytokines was revealing compared with the control group. The highest levels of IL-1β, IL-2 and IL-6 were detecting in the group of patients with comorbid pathology. IL-6 was found to be an independent marker of increased risk of STEMI and an increase in its concentration later than 12 hours after hospitalization is associated with the risk of future cardiovascular death or new myocardial infarction.

Conclusion: Analysis of the dynamics of the level of IL-1β, IL-2 and IL-6 has a high prognostic value in patients with myocardial infarction and in patients with comorbid pathology.
Swyer Syndrome
Authors: Gazizova G. R. , Valeeva F. V. , Shaydullina M. R. , Akbirova E. I.
Published: September 2020

A clinical observation of a patient with Swyer's syndrome is presented. The article presents anamnesis data, phenotypic signs, clinical symptoms and objective data of the patient, the results of instrumental and hormonal studies, on the basis of which doctors of different specialties may suspect a violation of sex formation with XY gonadal dysgenesis.
Logistic Regression Under Sparse Data Conditions
Authors: Walker David A. , Smith Thomas J.
Published: September 2020

The impact of sparse data conditions was examined among one or more predictor variables in logistic regression and assessed the effectiveness of the Firth (1993) procedure in reducing potential parameter estimation bias. Results indicated sparseness in binary predictors introduces bias that is substantial with small sample sizes, and the Firth procedure can effectively correct this bias.
Regional Press and Censorship in the New Economic Policy Period (Saratov, Samara Regions and the German Autonomy)
Authors: Khroustaleva Anna V.
Published: September 2020

The censorship process during the New Economic Policy Period was rather unbalanced due to the human factor. Up until 1928, certain stages of censoring the manuscript that started with initial reading and resulted in the approving mark on the typographical card, could be omitted, as the case of Saratov author L.A. Slovokhotov illustrates. The study of the archives shows that the attitude to the media in foreign languages issued by national minorities was more lenient than the attitude to religious media in the Russian language. The 1926 editorial of the leading newspaper of the German minorities of the Volga region had no reference to either the October Revolution or Vladimir Lenin. The German Autonomy published Catholic literature that beat the circulation of the proletarian literature. Censors approved the publication of a religious calendar in German and banned the same type of calendar in Russian. These facts demonstrate that we should examine typographical cards more carefully than hitherto practiced.
Um pouco da história da Geografia do Colégio de Aplicação da UFRGS: uma entrevista com a professora Neiva Otero Schäffer
Authors: Oliveira Victor Hugo Nedel , Schäffer Neiva Otero
Published: September 2020

A professora Neiva Otero Schäffer foi professora de Geografia no Colégio de Aplicação da UFRGS entre os anos de 1966 e 1969. Vivenciou importantes momentos históricos em seu espaço e tempo de trabalho. Este artigo apresenta uma retomada de sua trajetória, dando destaque para suas experiências de vida, acadêmicas e profissionais, bem como assinalando práticas de ensino de Geografia as quais a professora Neiva reconhece como de destaque. São apresentadas sínteses analíticas da vida e obra desta professora que colaborou na construção de um ensino de Geografia diferenciado. Para finalizar a professora Neiva apresenta, a partir de suas experiências, algumas pistas para os jovens professores de Geografia.
Transparency and Accountability Based on The Concept of “Pada Gelahang” Enhancing Village Financial Management
Authors: Budiasni Ni Wayan Novi , Ayuni Ni Made Sri
Published: September 2020

Along with the increase in the amount of village funds and the efforts to decrease the mismanagement carried out by the government, the Government strives to defend the WTP opinion by adapting local wisdom in managing finances. This study aims to analyze the variables of transparency and accountability based on the concept of pada gelahang in the village financial management. The research was a quantitative with SEM (Structural Equation Modelling) analysis tool and using PLS (Partial Least Square) method.  The sample of this study is 57 Village in Buleleng Regency. The results showed that transparency had an effect on the management of village finances (tcount >ttable = 3,501>1,960) and accountability had an effect on the management of village finances (tcount >ttable = 5,571>1,960). Thus, it is found that transparency and accountability based on the concept of pada gelahang have an effect on village financial management. The concept of the pada gelahang has the meaning of equality, togetherness and mutual assistance reflected in the financial management of the village that is transaparan and accountable.
PRIMER REGISTRO DE COLPOCEPHALUM TRICHOSUM HARRISON, 1916 (PHTHIRAPTERA: MENOPONIDAE) EN EL CÓNDOR ANDINO (VULTUR GRYPHUS LINNAEUS, 1758), EN LA PAZ BOLIVIA
Authors: Mollericona Jose Luis , Beltrán Luis , Rodríguez Iván
Published: September 2020

Entre las 1.435 aves presentes en Bolivia, el cóndor (Vultur gryphus Linnaeus, 1758) de la familia Cathartidae, enfrenta amenazas a lo largo de su distribución en la Cordillera de los Andes, como la disminución de su población a consecuencia de la pérdida de hábitat, la caza, el conflicto por depredación, así como la asilvestría de animales domésticos y, junto con las escasas investigaciones en salud, ponen más aún en riesgo a esta especie. En el presente estudio, realizamos el diagnóstico del piojo Colpocephalum trichosum Harrison, 1916 de la familia Menoponidae, Suborden Mallophaga del Orden Phthiraptera, de un individuo hembra cóndor de vida libre que fue encontrado lesionado en el municipio de Palca y rehabilitado en el Zoológico Municipal Vesty Pakos, para su posterior liberación y reintroducirla a la vida silvestre. Siendo el primer registro de parásitos en el cóndor para Bolivia.
CORONAVIRUS COVID-19: CONOCIENDO AL CAUSANTE DE LA PANDEMIA
Authors: Salas-Asencios Ramses , Iannacone-Oliver José , Guillén-Oneeglio Alfredo , Tantaléan-Da Fieno José , Alvariño-Flores Lorena , Castañeda-Pérez Luz , Cuellar-Ponce de León Luis
Published: September 2020

El presente artículo presenta una revisión y análisis de las principales investigaciones realizadas sobre el virus SARS-CoV-2 y de la enfermedad que produce (enfermedad por infección por coronavirus, con las siglas en inglés COVID-19). Este virus es conocido de manera coloquial como coronavirus debido a su estructura glicoproteica similar a una corona de puntas, tiene un genoma constituido por una cadena simple de ARN de sentido positivo y es el causante de la actual pandemia iniciada en el 2019 en Wuhan (China) y que viene afectando a más de 199 países o territorios de forma muy relevante. Las semejanzas genéticas de este coronavirus con un virus encontrado en un murciélago, involucran a esta especie como el origen del traspaso al hombre. Si bien este virus ha sido investigado recientemente, ya se conocen sus características morfológicas, estructurales, de replicación, y síntomas. Se ha avanzado en las técnicas de diagnóstico, epidemiología (se describen las fases del desarrollo de la epidemia en el Perú), transmisión, prevención y tratamiento, lo cual se ha consolidado en esta publicación. Considerándose que a la fecha (30.03.20), hay más de 722 mil infectados y han fallecido más de 34 mil pacientes en el mundo (pese a las acciones de aislamiento y distanciamiento social en las que nos encontramos) es eminente la urgente necesidad de desarrollar y usar una vacuna efectiva contra este virus. La OMS (Organización Mundial de la Salud) ha informado que se encuentran en pruebas de fase clínica 44 potenciales vacunas, ello nos podría anunciar la solución relativamente a corto plazo para esta pandemia que en pleno siglo XXI, pretende cambiar nuestras vidas.
Performance Comparison of Data Sampling Techniques to Handle Imbalanced Class on Prediction of Compound-Protein Interaction
Authors: Purnajaya Akhmad Rezki , Kusuma Wisnu Ananta , Hardhienata Medria Kusuma Dewi
Published: September 2020

The prediction of Compound-Protein Interactions (CPI) is an essential step in the drug-target analysis for developing new drugs as well as for drug repositioning. One challenging issue in this field is that commonly there are more numbers of non-interacting compound-protein pairs than interacting pairs. This problem causes bias, which may degrade the prediction of CPI. Besides, currently, there is not much research on CPI prediction that compares data sampling techniques to handle the class imbalance problem. To address this issue, we compare four data sampling techniques, namely Random Under-sampling (RUS), Combination of Over-Under-sampling (COUS), Synthetic Minority Over-sampling Technique (SMOTE), and Tomek Link (T-Link). The benchmark CPI data: Nuclear Receptor and G-Protein Coupled Receptor (GPCR) are used to test these techniques. Area Under Curve (AUC) applied to evaluate the CPI prediction performance of each technique. Results show that the AUC values for RUS, COUS, SMOTE, and T-Link are 0.75, 0.77, 0.85 and 0.79 respectively on Nuclear Receptor data and 0.70, 0.85, 0.91 and 0.72 respectively on GPCR data. These results indicate that SMOTE has the highest AUC values. Furthermore, we found that the SMOTE technique is more capable of handling class imbalance problems on CPI prediction compared to the remaining three other techniques.
Amtsal and Qashas Normative Study: Analysis of Islamic Education Implementation
Authors: Ichsan Yazida , Salsabila Unik Hanifah , Husna Difa’ul
Published: September 2020

Amtsal and qashas in the Qur'an can apply as a method and material. The technique uses a systematic way to achieve specific goals - the content as a study discussion or as the theme of the debate in individual learning. The application of amtsal and qashas in the Qur'an would need to use integrating normative tools with several approaches: psychology, linguistics, science, anthropology, sociology as benchmarks in learning. The application of methods in particular operational and operational periods, qashas, and amtsal can be presented as a descriptive narrative that presented with a gripping narration, diction, and vocals that will make students very interested and can take the lessons in question. The development of amtsal and qashas information technology can also modify with socio drama, visual, and video. However, in subsequent events, a child's cognitive development in the conceptual operational phase uses historical, sociological, legal, anthropological, scientific, and technological perspectives, become something that needs to use.
Neuromiotonia: Recordando uma Doença Rara
Authors: Martins Sara Raquel , Xavier Pires Sara , Marinho António
Published: September 2020

A neuromiotonia é uma patologia muito rara, maioritariamente adquirida e de provável fundo autoimune. Caracteriza-se por hiperexcitabilidade dos nervos periféricos com subsequente hiperatividade e défice de relaxamento muscular; fazendo-se frequentemente acompanhar de distúrbios autonómicos e sensitivos. O diagnóstico estabelece-se através de eletromiografia, com o achado de múltiplos disparos espontâneos de potenciais de elevada frequência originados numa unidade motora única; sendo relevante não só para o controlo de sintomas potencialmente disruptivos com terapêutica adequada, mas também pela conhecida associação desta patologia a neoplasias – que devem sempre ser excluídas. No entanto, devido à raridade e à sintomatologia inespecífica e variável, o diagnóstico é difícil, sendo facilmente confundido com as mais comuns doenças psiquiátricas ou do primeiro neurónio, cujas terapêuticas podem resultar em iatrogenia adicional. Nesse sentido, trazemos um caso típico de neuromiotonia, a propósito da qual se recordam a sintomatologia habitual, meios complementares de diagnóstico, evolução natural e tratamentos efetivos da doença.
Pre-service and in-service teachers’ interest, knowledge, and self-confidence in using educational robotics in learning activities
Authors: Piedade João Manuel Nunes
Published: September 2020

This paper presents a study that aims to analyze the interest, knowledge, problem-solving skills, and self-confidence of the pre-service and in-service teachers in using educational robotics for teaching purposes, in particular, to teach programming and computational thinking in primary and secondary education. In the portuguese context, it is mandatory to attend a masters in teaching in order to become a teacher in primary and secondary education. These pre-service teacher training programs are organized in several dimensions, such as specific didactics, general education, scientific area. Computational Thinking, programming, and robotics have been integrated into the schools’ curriculum in many countries. Accordingly, it is essential to analyze the teachers’ preparation to teach these thematic trends. A descriptive and exploratory quantitative approach was implemented with 49 participants. The results pointed out a positive level of interest, educational robotics knowledge, problem-solving, self-confidence of both pre-service and in-service teachers.
Estudo do perfil epidemiológico da tuberculose em Araraquara, SP, no período 2012 - 2017
Authors: Bonini Eduardo Henrique , Massabni Antonio Carlos
Published: September 2020

Introdução: A tuberculose (TB) afeta 1/3 da população mundial e cerca de 10 milhões de pessoas desenvolvem TB a cada ano, resultando em mais de dois milhões de mortes. Objetivos: O principal objetivo deste trabalho é apresentar um estudo do perfil epidemiológico da TB em Araraquara (SP) e comparar o perfil epidemiológico da TB em Araraquara com os padrões da doença no mundo, Américas, Brasil e Estado de São Paulo. Método: As pesquisas e informações foram coletadas do relatório anual da Organização Mundial da Saúde (OMS), do Ministério da Saúde do Brasil, da Secretaria do Estado de São Paulo, da Secretaria Municipal de Saúde e do Serviço Especial de Saúde de Araraquara (SESA). O período de 2012 a 2017 foi analisado considerando-se as projeções das metas da OMS para o fim da TB de 2015 a 2035. Resultados: Todos os dados apresentados, com exceção da cidade de Araraquara, estão acima da projeção requerida pela OMS. Embora ligeiramente abaixo da projeção citada, Araraquara está se encaminhando para reduzir a incidência de TB até o ponto de erradicar a doença. conclusões: Os baixos níveis atuais de infecção por TB em Araraquara podem ser explicados por fatores como, um dos maiores Índices de Desenvolvimento Humano (IDH) do País, a existência de um sanatório especializado no tratamento da doença, políticas públicas e uma eficiente rede de informações sobre TB . Araraquara pode ser um modelo no combate à doença no nível nacional e erradicar a doença  até antes do prazo estabelecido pela OMS.
Ações de enfermagem na promoção da saúde e qualidade de vida de mulheres no climatério
Authors: Patrício Rute Silva de Oliveira , Carvalho Ribeiro Junior Orácio , Ferreira Suzana Maria da Silva , Araújo Tatiane Silva de , Brasil Luciane Cativo , Silva Jociane Martins da , Barbosa Miquele Soares , Cordeiro Antônio Victor Souza , Pereira Lucas Saboia , Araújo Murilo Henrique Nascimento
Published: September 2020

Os sinais e sintomas que compõem a síndrome climatérica geram consequências que podem afetar o bem-estar da mulher, devido ao preconceito e tabus levantados pela sociedade ao longo dos anos. Objetivou-se apresentar as experiências e as atividades vivenciadas por acadêmicas de enfermagem durante a disciplina de estágio supervisionado em saúde da mulher nas ações de cuidado integral às mulheres climatéricas em um parque municipal em uma cidade do Amazonas. As ações foram realizadas mediante adesão voluntária das mulheres, que posteriormente foram acompanhadas por meio da consulta de enfermagem, guiada por instrumentos específicos, bem como, ações de educação em saúde e escuta individualizada de cada participante sobre o climatério, suas características e manejo. Considerações Finais: As atividades desenvolvidas junto a esta população mostraram-se satisfatórias para o público que acompanhou e usufruiu dos serviços disponibilizados. Para as acadêmicas, figurou a oportunidade de aplicar os conhecimentos científicos do cuidado em enfermagem numa realidade de saúde diferenciada. A assistência integral mostrou-se ponto estratégico para despertar novamente a autoestima dessas mulheres, de modo que possam se perceber como protagonistas no seu autocuidado, de modo a agir para garantir seu bem-estar e qualidade de vida.
ISSUES OF ENSURING ECONOMIC AND ENERGY SECURITY IN THE “SMART CITY” SYSTEM
Authors: Zotova A. S. , Svetkina I. A. , Gilmanova D. R.
Published: September 2020

The publication reflects the results of research on economic security issues at the level of administrative center of the subject of the Russian Federation in the context of the development of the “smart city” system. Cutting-edge technologies are becoming a powerful engine of transformation, including the energy sector. Development of smart cities and digitalization of services require reorganization of the energy business, search of new innovative opportunities and the development of new strategies, the final result of which will be the creation of new business models for energy suppliers. As a result of largescale statistics and practical cases analysis the main (specific) smart risks, smart challenges and smart threats for the economic security system of the largest city have been classified, recommendations to modify existing business models for Russian energetic industry have been offered.
Post-Synthetic Modification of Covalent Organic Frameworks via in Situ Polymerization of Aniline for Enhanced Capacitive Energy Storage
Authors: Dutta Tapas , Patra Abhijit
Published: September 2020

Covalent organic frameworks (COFs) with layered architecture with open nanochannels and high specific surface areas are promising candidates for energy storage. However, the low electrical conductivity of two-dimensional COFs often limits their scope in energy storage applications. The conductivity of COFs can be enhanced through post-synthetic modification with conducting polymers. Herein, we developed polyaniline (PANI) modified triazine-based COFs via in situ polymerization of aniline with the porous frameworks. The composite materials showed high conductivity of 1.4-1.9 x 10-2 S cm-1 at room temperature with 10-fold enhancement in specific capacitance than the pristine frameworks. The fabricated supercapacitor exhibited a high energy density of 24.4 W h kg-1 and a power density of 200 W kg-1 at 0.5 A g-1 current density. Moreover, the device fabricated using the conducting polymer-triazine COF composite can light up a green light-emitting diode for 1 min after being charged for 10 s.
Measuring Theoretical Descriptors of Water Oxidation: Free Energy Differences Between Intermediates Using Time-Resolved Optical Spectroscopy
Authors: Vinogradov Ilya , Singh Suryansh , Lyle Hanna , Mandal Aritra , Rossmeisl Jan , Cuk Tanja
Published: September 2020

Theoretical descriptions differentiate catalytic activity of material surfaces for the water oxidation reaction by the stability of the reactive oxygen (O*) intermediate. The underlying conjecture is that there are several meta-stable steps of the reaction, each connected by free energy differences critically dependent on O*. Recently in-situ, time-resolved spectroscopy of the (photo)-electrochemical water oxidation reaction identified the vibrational and optical signatures of O* time-evolution. However, there has been little connection between these inherently kinetic experiments and the underlying thermodynamic parameters of the theory. Here, we discover that picosecond optical spectra of the O* population modulated by a shift in reaction equilibria defines an effective equilibrium constant (Keff) containing the relevant free-energy differences. A Langmuir isotherm as a function of electrolyte pH extracts Keff using a model titania system (SrTiO3). The results show how to obtain equilibrium constants of individual reaction steps on material surfaces, which had not been experimentally accessible previously. Further, we find that for a photo-excited reaction on a semiconductor surface tuning past a pH defined by Keff doubles the initial O* population. That the free energies of the catalytic surface are definable through a time-resolved spectroscopy, alongside the finding that the surface recollects its explicit equilibrium with the electrolyte, provides a new and critical connection between theory and experiment by which to tailor the pathway of water oxidation and other surface reactions.
Prediction and Validation of a Druggable Site on Virulence Factor of Drug Resistant Burkholderia Cenocepacia
Authors: Lal Kanhaya , Bermo Rafael , Cramer Jonathan , Vasile Francesca , Ernst Beat , Imberty Anne , Bernardi Anna , Varrot Annabelle , Belvisi Laura
Published: September 2020

We use a virtual screening approach to explore the binding pocket close to the fucose binding site in a lectin from opportunistic pathogen. This is a novel approach for designing anti-adhesive drugs, and it has been very successful since we were able to obtain leads with sub millimolar affinity. Furthermore, the crystal structure of the target protein complexed with the fragment validated the existence of this secondary binding site, opening route for new design of inhibitors
Membangun Lingkungan yang Berbasis Konsep Berkelanjutan
Authors: Maryanto Maryanto
Published: September 2020

Dalam pembangunan ekonomi harus memperhatikan prinsip-prinsip dalam pembangungan yang berkelanjutan. Prinsip-prinsip tersebut adalah: Prinsip Keadilan antar generasi (intergenerational equity), Prinsip Keadilan dalam satu generasi (intra Generational equity), Prinsip Pencegahan Dini (precautionary), Prinsip perlindungan keragaman hayati (conservation of biological diversity), Prinsip Internalisasi biaya lingkungan. Prinsip tersebut pada hakekatnya adalah perlindungan dan pengelolaan lingkungan hidup, sehingga dalam melaksanakan pembangunan lingkungan tetap terjaga dengan baik.
representações sociais da paternidade
Authors: Danese Maria Célia Ferreira , Silva Débora Rosa da , Exaltação Juliane do Nascimento Silva
Published: September 2020

Este trabalho retrata os aspectos subjetivos à paternidade na adolescência, bem como os fatores de risco relacionados ao fenômeno da gravidez nesse período, que é considerada uma problemática de grandes proporções na sociedade atual. Tem como objetivo explorar o “mundo” da paternidade por meio dos principais atores envolvidos neste processo, as im­plicações sociais decorrentes de uma gravidez vivenciadas pelo pai adolescente, além dos impactos das mudanças nesta fase da vida. Para o presente estudo utilizou-se da Teoria das Representações Sociais para fundamentá-lo e de um questionário semiestruturado para coleta de dados. Conclui-se com este trabalho que o contexto familiar está diretamente relacionado aos fatores da gravidez na adolescência e que o pai, também envolvido neste processo, fica a mercê no que diz respeito aos programas de assistência à saúde.