bluuebunny/crossref_metadata_2025 huggingface dataset:
Identification of Efficacy-Associated Markers to Discriminate Flos Chrysanthemum and Flos Chrysanthemi Indici Based on Fingerprint–Activity Relationship Modeling: A Combined Evaluation over Chemical Consistence and Quality Consistence
Authors: Liu Feng , Zheng Yuanrong , Hong Huijie , Liu Lianliang , Chen Xiaojia , Xia Qiang
Published: August 2023

Monitoring the quality consistency of traditional Chinese medicines, or herbal medicines (HMs), is the basis of assuring the efficacy and safety of HMs during clinical applications. The purpose of this work was to characterize the difference in hydrophilic antioxidants and related bioactivities between Flos Chrysanthemum (JH) and its wild relatives (Chrysanthemum indicum L.; YJH) based on the establishment of fingerprint–efficacy relationship modeling. The concentrations of the total phenolics and flavonoids of JH samples were shown to be generally higher than those of YJH, but the concentration distribution ranges of YJH were significantly greater compared to JH samples, possibly related to environmental stress factors leading to the concentration fluctuations of phytochemicals during the growth and flowering of Chrysanthemum cultivars. Correspondingly, the total antioxidant capabilities of JH were greatly higher than those of YJH samples, as revealed by chemical assays, including DPPH and ABTS radical scavenging activities and FRAP assays. In addition, cellular-based antioxidant activities confirmed the results of chemical assays, suggesting that the differences in antioxidant activities among the different types of Chrysanthemums were obvious. The extracts from YJH and JH samples showed significant α-glucosidase inhibitory activity and lipase-inhibitory activity, implying the modulatory effects on lipid and glucose metabolisms, which were also confirmed by an untargeted cell-based metabolomics approach. The selected common peaks by similarity analysis contributed to the discrimination of YJH and JH samples, and the modeling of the fingerprint–bioactivity relationship identified neochlorogenic acid, isochlorogenic acid A, and linarin as efficacy-associated chemical markers. These results have demonstrated that integrating HPLC fingerprints and the analysis of similarity indexes coupled with antioxidant activities and enzyme-inhibitory activities provides a rapid and effective approach to monitoring the quality consistency of YJH/JH samples.
Essential Oil of Bursera morelensis Promotes Cell Migration on Fibroblasts: In Vitro Assays
Authors: Salas-Oropeza Judith , Rodriguez-Monroy Marco Aurelio , Jimenez-Estrada Manuel , Perez-Torres Armando , Castell-Rodriguez Andres Eliu , Becerril-Millan Rodolfo , Jarquin-Yanez Katia , Canales-Martinez Maria Margarita
Published: August 2023

Essential oils (EOs) are complex mixtures of volatile natural compounds. We have extensively studied the EO of Bursera morelensis, which demonstrates antibacterial, antifungal, anti-inflammatory, and wound-healing activities. The objective of this work was to determine the effect of this EO on fibroblast migration in a three-dimensional in vitro model. For the three-dimensional in vitro model, a series of fibrin hydrogel scaffolds (FSs) were built in which fibroblasts were cultured and subsequently stimulated with fibroblast growth factor (FGF) or EO. The results demonstrated that these FSs are appropriate for fibroblast culture, since no decrease in cell viability or changes in cell proliferation were found. The results also showed that this EO promotes cell migration four hours after stimulation, and the formation of cell projections (filopodia) outside the SF was observed. From these results, we confirmed that part of the mechanism of action of the essential oil of B. morelensis during the healing process is the stimulation of fibroblast migration to the wound site.
Detection of Polonium-210 in Environmental, Biological and Food Samples: A Review
Authors: Zhou Lei , Wang Rui , Ren Hong , Wang Peng , Cao Yiyao
Published: August 2023

Ingestion of polonium-210 from environmental media and food can cause serious health hazards (e.g., gastrointestinal symptoms, tumours, etc.) and has been a public health concern worldwide since the 2006 poisoning of Agent Litvinenko 210Po in Russia. With the development of uranium mining and applications of nuclear technology in recent decades, the radioactive hazards posed by 210Po to living organisms and the environment have become increasingly prominent. In order to strengthen the monitoring of environmental 210Po and protect both the environment and human health, a series of explorations on the methods of 210Po determination have been ongoing by researchers across the globe. However, previous reviews have focused on individual sample types and have not provided a comprehensive account of environmental, food, and biological samples that are closely related to human health. In this work, the sources, health hazards, chemical purification, and detection methods of trace 210Po in different sample types are systematically reviewed. In particular, the advantages and disadvantages of various pretreatment methods are compared, and relevant domestic and international standards are integrated, which puts forward a new direction for the subsequent establishment of rapid, simple, and efficient measurement methods.
The Protective Role of Dietary Polyphenols in Urolithiasis: Insights into Antioxidant Effects and Mechanisms of Action
Authors: Hong Sen-Yuan , Qin Bao-Long
Published: August 2023

Urolithiasis is a common urological disease with increasing prevalence and high recurrence rates around the world. Numerous studies have indicated reactive oxygen species (ROS) and oxidative stress (OS) were crucial pathogenic factors in stone formation. Dietary polyphenols are a large group of natural antioxidant compounds widely distributed in plant-based foods and beverages. Their diverse health benefits have attracted growing scientific attention in recent decades. Many literatures have reported the effectiveness of dietary polyphenols against stone formation. The antiurolithiatic mechanisms of polyphenols have been explained by their antioxidant potential to scavenge free radicals and ROS, modulate the expression and the activity of endogenous antioxidant and prooxidant enzymes, regulate signaling pathways associated with OS, and maintain cell morphology and function. In this review, we first describe OS and its pathogenic effects in urolithiasis and summarize the classification and sources of dietary polyphenols. Then, we focus on the current evidence defining their antioxidant potential against stone formation and put forward challenges and future perspectives of dietary polyphenols. To conclude, dietary polyphenols offer potential applications in the treatment and prevention of urolithiasis.
Forgiving Others: Pastoral Care of Forgiveness in Post-Secular Societies
Authors: Christoffersen Mikkel Gabriel
Published: August 2023

This article argues that pastoral insights into the dynamics of forgiveness are also relevant for pastoral care in post-secular society. While receiving forgiveness has been the raison d’etre of the sacrament of penance (a historical precursor to modern pastoral care), contemporary post-secular societies accentuate the problem of forgiving others. This article explores several paths for forgiving others that care seekers can walk, guided by pastors who provide maps and signposts. Methodologically, this article analyzes two pastoral care conversations about forgiving others, published in a Danish podcast series on the official homepage of the Evangelical Lutheran Church of Denmark. These two conversations present a highway of unconditional forgiveness, in contrast to the dead end of not being able to forgive. This article explores how pastors can care for care seekers along these diametric roads, and along several byways, through surveys of relevant (theological) philosophy, systematic theology, and theology of pastoral care. The two care seekers are neither religious nor simply secular; they are post-secular, moving in and out of secular and religious discourses as appears relevant. The article concludes with reflections on pastoral care in different intercultural settings, specifically in post-secular societies.
Fisher-Information-Matrix-Based USBL Cooperative Location in USV–AUV Networks
Authors: Wang Ziyuan , Xu Jingzehua , Feng Yuanzhe , Wang Yijing , Xie Guanwen , Hou Xiangwang , Men Wei , Ren Yong
Published: August 2023

With the development of underwater technology and the increasing demand for ocean development, more and more intelligent equipment is being applied to underwater scientific missions. Specifically, autonomous underwater vehicle (AUV) clusters are being used for their flexibility and the advantages of carrying communication and detection units, often performing underwater tasks in formation. In order to locate AUVs with high precision, we introduce an unmanned surface vehicle (USV) with global positioning system (GPS) and propose a USV–AUV network. Furthermore, we propose an ultra-short baseline (USBL) acoustic cooperative location scheme with an orthogonal array, which is based on underwater communication with sonar. Based on the derivation of the Fisher information matrix formula under Cartesian parameters, we analyze the positioning accuracy of AUVs in different positions under the USBL positioning mode to derive the optimal array of the AUV formation. In addition, we propose a USV path planning scheme based on Dubins path planning functions to assist in locating the AUV formation. The simulation results verify that the proposed scheme can ensure the positioning accuracy of the AUV formation and help underwater research missions.
Cross-Component Transferable Transformer Pipeline Obeying Dynamic Seesaw for Rotating Machinery with Imbalanced Data
Authors: Xu Binbin , Ma Boquan , Yang Zheng , Chen Fei , Li Xiaobing
Published: August 2023

Due to the lack of fault data in the daily work of rotating machinery components, existing data-driven fault diagnosis procedures cannot accurately diagnose fault classes and are difficult to apply to most components. At the same time, the complex and variable working conditions of components pose a challenge to the feature extraction capability of the models. Therefore, a transferable pipeline is constructed to solve the fault diagnosis of multiple components in the presence of imbalanced data. Firstly, synchrosqueezed wavelet transforms (SWT) are improved to highlight the time-frequency feature of the signal and reduce the time-frequency differences between different signals. Secondly, we proposed a novel hierarchical window transformer model that obeys a dynamic seesaw (HWT-SS), which compensates for imbalanced samples while fully extracting key features of the samples. Finally, a transfer diagnosis between components provides a new approach to solving fault diagnosis with imbalanced data among multiple components. The comparison with the benchmark models in four datasets proves that the proposed model has the advantages of strong feature extraction capability and low influence from imbalanced data. The transfer tests between datasets and the visual interpretation of the model prove that the transfer diagnosis between components can further improve the diagnostic capability of the model for extremely imbalanced data.
Surface Defect Detection of Bearing Rings Based on an Improved YOLOv5 Network
Authors: Xu Haitao , Pan Haipeng , Li Junfeng
Published: August 2023

Considering the characteristics of complex texture backgrounds, uneven brightness, varying defect sizes, and multiple defect types of the bearing surface images, a surface defect detection method for bearing rings is proposed based on improved YOLOv5. First, replacing the C3 module in the backbone network with a C2f module can effectively reduce the number of network parameters and computational complexity, thereby improving the speed and accuracy of the backbone network. Second, adding the SPD module into the backbone and neck networks enhances their ability to process low-resolution and small-object images. Next, replacing the nearest-neighbor upsampling with the lightweight and universal CARAFE operator fully utilizes feature semantic information, enriches contextual information, and reduces information loss during transmission, thereby effectively improving the model’s diversity and robustness. Finally, we constructed a dataset of bearing ring surface images collected from industrial sites and conducted numerous experiments based on this dataset. Experimental results show that the mean average precision (mAP) of the network is 97.3%, especially for dents and black spot defects, improved by 2.2% and 3.9%, respectively, and that the detection speed can reach 100 frames per second (FPS). Compared with mainstream surface defect detection algorithms, the proposed method shows significant improvements in both accuracy and detection time and can meet the requirements of industrial defect detection.
Small-Molecule Analysis Based on DNA Strand Displacement Using a Bacteriorhodopsin Photoelectric Transducer: Taking ATP as an Example
Authors: Chen Hsiu-Mei , Wang Wen-Chang , Chen Hong-Ren
Published: August 2023

A uniformly oriented purple membrane (PM) monolayer containing photoactive bacteriorhodopsin has recently been applied as a sensitive photoelectric transducer to assay color proteins and microbes quantitatively. This study extends its application to detecting small molecules, using adenosine triphosphate (ATP) as an example. A reverse detection method is used, which employs AuNPs labeling and specific DNA strand displacement. A PM monolayer-coated electrode is first covalently conjugated with an ATP-specific nucleic acid aptamer and then hybridized with another gold nanoparticle-labeled nucleic acid strand with a sequence that is partially complementary to the ATP aptamer, in order to significantly minimize the photocurrent that is generated by the PM. The resulting ATP-sensing chip restores its photocurrent production in the presence of ATP, and the photocurrent recovers more effectively as the ATP concentration increases. Direct and single-step ATP detection is achieved in 15 min, with detection limits of 5 nM and a dynamic range of 5 nM–0.1 mM. The sensing chip exhibits high selectivity against other ATP analogs and is satisfactorily stable in storage. The ATP-sensing chip is used to assay bacterial populations and achieves a detection limit for Bacillus subtilis and Escherichia coli of 102 and 103 CFU/mL, respectively. The demonstration shows that a variety of small molecules can be simultaneously quantified using PM-based biosensors.
Performance Optimization in Frequency Estimation of Noisy Signals: Ds-IpDTFT Estimator
Authors: Wei Miaomiao , Zhu Yongsheng , Sun Jun , Lu Xiangyang , Mu Xiaomin , Xu Juncai
Published: August 2023

This research presents a comprehensive study of the dichotomous search iterative parabolic discrete time Fourier transform (Ds-IpDTFT) estimator, a novel approach for fine frequency estimation in noisy exponential signals. The proposed estimator leverages a dichotomous search process before iterative interpolation estimation, which significantly reduces computational complexity while maintaining high estimation accuracy. An in-depth exploration of the relationship between the optimal parameter p and the unknown parameter δ forms the backbone of the methodology. Through extensive simulations and real-world experiments, the Ds-IpDTFT estimator exhibits superior performance relative to other established estimators, demonstrating robustness in noisy conditions and stability across varying frequencies. This efficient and accurate estimation method is a significant contribution to the field of signal processing and offers promising potential for practical applications.
Quantum Random Access Memory for Dummies
Authors: Phalak Koustubh , Chatterjee Avimita , Ghosh Swaroop
Published: August 2023

Quantum Random Access Memory (QRAM) has the potential to revolutionize the area of quantum computing. QRAM uses quantum computing principles to store and modify quantum or classical data efficiently, greatly accelerating a wide range of computer processes. Despite its importance, there is a lack of comprehensive surveys that cover the entire spectrum of QRAM architectures. We fill this gap by providing a comprehensive review of QRAM, emphasizing its significance and viability in existing noisy quantum computers. By drawing comparisons with conventional RAM for ease of understanding, this survey clarifies the fundamental ideas and actions of QRAM. QRAM provides an exponential time advantage compared to its classical counterpart by reading and writing all data at once, which is achieved owing to storage of data in a superposition of states. Overall, we compare six different QRAM technologies in terms of their structure and workings, circuit width and depth, unique qualities, practical implementation, and drawbacks. In general, with the exception of trainable machine learning-based QRAMs, we observe that QRAM has exponential depth/width requirements in terms of the number of qubits/qudits and that most QRAM implementations are practical for superconducting and trapped-ion qubit systems.
A Survey on Industrial Internet of Things Security: Requirements, Attacks, AI-Based Solutions, and Edge Computing Opportunities
Authors: Alotaibi Bandar
Published: August 2023

The Industrial Internet of Things (IIoT) paradigm is a key research area derived from the Internet of Things (IoT). The emergence of IIoT has enabled a revolution in manufacturing and production, through the employment of various embedded sensing devices connected by an IoT network, along with a collection of enabling technologies, such as artificial intelligence (AI) and edge/fog computing. One of the unrivaled characteristics of IIoT is the inter-connectivity provided to industries; however, this characteristic might open the door for cyber-criminals to launch various attacks. In fact, one of the major challenges hindering the prevalent adoption of the IIoT paradigm is IoT security. Inevitably, there has been an inevitable increase in research proposals over the last decade to overcome these security concerns. To obtain an overview of this research area, conducting a literature survey of the published research is necessary, eliciting the various security requirements and their considerations. This paper provides a literature survey of IIoT security, focused on the period from 2017 to 2023. We identify IIoT security threats and classify them into three categories, based on the IIoT layer they exploit to launch these attacks. Additionally, we characterize the security requirements that these attacks violate. Finally, we highlight how emerging technologies, such as AI and edge/fog computing, can be adopted to address security concerns and enhance IIoT security.
A Real-Time Path Planning Method for Urban Low-Altitude Logistics UAVs
Authors: Deng Minyi , Yang Qingqing , Peng Yi
Published: August 2023

To solve the problem of poor real-time performance in path planning algorithms for unmanned aerial vehicles (UAVs) in low-altitude urban logistics, a path planning method combining modified Beetle Antennae Search (BAS) with the Simulated Annealing (SA) algorithm is proposed. Firstly, based on the requirements of task execution and constraints of UAV flight, a fitness function for real-time search of waypoints is designed while ensuring the safety and obstacle avoidance of the UAV. Then, to improve the search accuracy and real-time performance, determining the initial search direction in the BAS algorithm is improved, while the search step size and antennae sensing length are updated in real-time according to the distance between the UAV and the obstacle. Finally, the SA algorithm is combined with the BAS algorithm to update the waypoints, expanding the search range of each waypoint, avoiding the process of updating the waypoints from becoming trapped in the local optimal waypoints. Meanwhile, the effectiveness of the next waypoint is evaluated based on the Metropolis criterion. This paper generates a virtual urban logistics distribution environment based on the density and distribution of urban buildings, and compares the performance of algorithms in obstacle-sparse, obstacle-moderate, and obstacle-dense environments. The simulation results demonstrate that the improved method in this paper has a more significant capacity for environmental adaptation. In terms of the path length, waypoints, safety obstacle avoidance, and smoothness, the planned path outperforms the original BAS method. It satisfies the needs of real-time path planning for UAVs involved in urban low-altitude logistics.
A Vehicle Crash Simulator Using Digital Twin Technology for Synthesizing Simulation and Graphical Models
Authors: Nam Su Man , Park Jieun , Sagong Chaeyeon , Lee Yujin , Kim Hyung-Jong
Published: August 2023

Computer vehicle simulators are used to model real-world situations to overcome time and cost limitations. The vehicle simulators provide virtual scenarios for real-world driving. Although the existing simulators precisely observe movement on the basis of good-quality graphics, they focus on a few driving vehicles instead of accident simulation. In addition, it is difficult to represent vehicle collisions. We propose a vehicle crash simulator with simulation and animation components. The proposed simulator synthesizes and simulates models of vehicles and environments. The simulator animates corresponding to the simulation through the execution results. The simulation results validate that the proposed simulator provides collision and non-collision results according to the speed of two vehicles at an intersection.
Parameters of the autonomic nervous system and their interpretation in patients after acute myocardial infarction
Authors:   FSBEI HE Volgograd State Medical University, Skvortsov V. V. , Lyakh E. A. ,   FSBEI HE Volgograd State Medical University, Kurbanaliev M. K. ,   FSBEI HE Volgograd State Medical University
Published: August 2023

In cardiovascular diseases, including coronary heart disease (CHD) and myocardial infarction (MI), there are pronounced changes in the myocardium and the associated reconfiguration of the autonomic nervous system (ANS) of the heart. This leads to the damage to both sympathetic and parasympathetic regulatory influences. Great attention is paid to activation of the sympathoadrenal system and a decrease in the activity of the parasympathetic division of the ANS, associated both with an increase in the general adaptation syndrome and with a major restructuring of the myocardium, which indicates an increase in electrical instability, a tendency to dangerous cardiac arrhythmias and an increased risk of cardiac death. ANS disorders lead to the damage to the parasympathetic and sympathetic systems. A disorder in the latter causes such complications as orthostatic tachycardia, changes in heart rate, anxiety disorders, panic attacks resembling, and sleep disturbance. Coronary heart disease is one of the predisposing factors for the occurrence of autonomic dysfunction.
Anxiety and depressive disorders
Authors:   State Institution «Lugansk Republican Blood Transfusion Station», Lugansk, Sakhno N. N.
Published: August 2023

According to the WHO forecasts, depression will be one of the main causes of disability and will rank second after cardiovascular pathology by 2030. One of the main priorities of the problem under study is to identify the key predictors that affect the formation of anxiety, depression, and cognitive impairment, as well as to search for new treatment regimens for depressio
IDENTIFICATION AND DISTRIBUTION OF THE HH4 FERTILITY HAPLOTYPE OF HOLSTEIN CATTLE IN A SUBPOPULATION OF THE KRASNODAR TERRITORY
Authors: КОВАЛЮК Н.В. , ВОЛЧЕНКО А.Е. , ШИРЯЕВА Е.В. , ЯКУШЕВА Л.И. , ШАХНАЗАРОВА Ю.Ю.
Published: August 2023

Мутация, связанная с гаплотипом HH4, приводит к замене аденина (A) на цитозин (C) в положении 1277227 (g.1277227A>C) на хромосоме BTA1, что вызывает замену аспарагина на треонин в одном из белков (GART), необходимых для биосинтеза таких важных молекул, как ДНК, РНК, АТФ. Потеря функции GART вызывает гибель эмбрионов на самых ранних стадиях после оплодотворения. Нами разработана тест-система для идентификации животных — носителей гаплотипа НН4 — на основе методов ПЦР/ПДРФ. В статье приведены последовательности праймеров, условия ПЦР-реакции, указаны необходимая эндонуклеаза и условия рестрикции. С использованием контрольного образца проведены апробация разработанной тест-системы и генотипирование выборки (n=130) образцов крови коров и телок из 3 хозяйств Краснодарского края и спермы быков-производителей, принадлежащих двум племенным предприятиям. Установлено, что частота встречаемости носителей гаплотипа в протестированной выборке животных (2023 год) составила 1,5%.

The mutation associated with the haplotype HH4 leads to the replacement of adenine (A) with cytosine (C) at position 1277227 (g.1277227A>C) on the BTA1 chromosome, which causes the replacement of asparagine with threonine in one of the proteins (GART) necessary for the biosynthesis of such important molecules as DNA, RNA, ATF. Loss of GART function causes the death of embryos at the earliest stages after fertilization. We have developed a test system for the identification of haplotype HH4 carrier animals based on PCR/PDRF methods. The article presents the sequences of primers, the conditions of the PCR reaction, the necessary endonuclease and restriction conditions. With the use of a control sample, the developed test system was tested and a sample (n=130) of blood samples of cows and heifers from 3 farms of the Krasnodar Territory and sperm of bulls belonging to two breeding enterprises was genotyped. It was found that the frequency of occurrence of haplotype carriers in the tested sample of animals was 1.5%.
FLAXSEED FEED SUPPLEMENT FOR COWS
Authors: МИЛУШЕВ Р.К. , ШУЛАЕВ Г.М. , ДОРОВСКИХ В.И. , ЖАРИКОВ В.С.
Published: August 2023

Разработан состав кормовой добавки «Омегален» из льняного семени, кукурузы и биологически активных веществ (биоплексы йода и селена, витамин Е). Она представляет собой комбинацию синергически взаимодействующих компонентов, которые могут влиять на обмен веществ и продуктивность животных. Все компоненты находятся в органической форме и легко усваиваются организмом. Эффективность применения добавки исследована на коровах голштинской породы с удоем 8,5 тыс. кг за лактацию. Установлено, что применение ее в их рационе в количестве 0,75 кг на 1 голову в сутки в период раздоя улучшает обмен веществ: количество гемоглобина увеличилось на 4%, активность фермента гамма-глутамилтранспептидазы повысилась на 7 ед/л (P<0,05), молочная продуктивность выросла на 16,4%. Использование кормовой добавки в течение 58 дней было экономически оправдано, дало дополнительный доход на 1 корову 4461 руб. за счет увеличения продуктивности.

The composition of a feed additive made of flaxseed, corn and biologically active substances (iodine and selenium bioplexes, vitamin E) has been developed. It is a combination of synergistically interacting components that can influence the metabolism and productivity of animals. All components are in organic form and are easily absorbed by the body. The effectiveness of the additive was studied on Holstein cows with milk yield of 8.5 thousand kg per lactation. It was found that its use in their diet in the amount of 0.75 kg per 1 head per day during the period of milking improves metabolism: the amount of hemoglobin increased by 4%, the activity of the enzyme gamma-glutamyltranspeptidase increased by 7 units/l (P<0.05), milk productivity increased by 16.4%. The use of feed additive for 58 days was economically justified, gave additional income per 1 cow 4461 rubles due to increased productivity.
El desarrollo psicomotor en niños menores de 5 años con cardiopatía congénita, Madre de Dios-Perú
Authors: Quispe Layme Wilian , Quispe Aquise Jhemy , Cuse Quispe Jaime , Quispe Layme Marleny , Ramos Pillaca Vilma , Ccahuantico Ccasa Yessica
Published: August 2023

A nivel mundial, la cardiopatía congénita en los niños es la malformación más común que puede tener un bebé al nacer. Objetivo. Analizar el comportamiento del desarrollo psicomotor de los niños menores a 5 años con cardiopatía congénita en la región de Madre de Dios, Perú. Materiales y métodos. Se consideró un enfoque cuantitativo, de tipo observacional analítica con diseño de cohorte prospectivo, con muestreo no probabilístico y una muestra de 6 infantes a quienes se aplicó el instrumento de recolección de información “observación del desarrollo psicomotor en niños con cardiopatía congénita”. Resultados. El género del paciente varón en promedio es de 33.33%, la edad en promedio de los pacientes con cardiopatía congénita es de 2 años; el tipo de cardiopatía congénita de los pacientes es atresia pulmonar y estenosis aortica, mostrando un desarrollo psicomotor promedio de nivel medio; el tipo de cirugía desarrollado en el paciente en promedio es de tipo definitivo; alcanzando de esta manera una estancia hospitalaria de 16 a 30 días en promedio y alcanzando un estado nutricional promedio de desnutrición severa. Además, la relación entre el tipo de cardiopatía congénita con el desarrollo psicomotor es positiva, toda vez que, ante un incremento del desarrollo psicomotor de los pacientes, entonces los casos de cardiopatía congénita incrementan (? de Pearson =0.6919). Conclusiones. Se determinó que, en los pacientes estudiados el desarrollo psicomotor es de nivel medio; la misma que está relacionado por el tipo de cardiopatía congénita que tiene, donde el 33.33% de los pacientes presentan atresia pulmonar y el 16.67% tiene estenosis aortica; lo que demuestra que la relación entre el tipo de cardiopatía congénita con el desarrollo psicomotor es positiva o directa.
Propagación y prevención del dengue en la amazonia: Oportuna intervención en salud desde la educación
Authors: Maraza Vilcanqui Beker , Maraza Vilcanqui Nain , Flores Choque Gladys Martha , Maraza Vilcanqui Queke
Published: August 2023

La salud de la población selvática está en riesgo por la presencia del mosquito de la especie Aedes aegypti. Objetivo. Determinar el control de propagación y formas de prevención del dengue que afecta la salud de los pobladores de la región amazónica peruana. Materiales y métodos. Se realizó un estudio mixto, de carácter descriptivo fenomenológicos sobre la presencia del mosquito transmisor del dengue, la población estuvo constituida tres mil pobladores que viven alrededor de la laguna Yarinacocha en el distrito de Yarinacocha provincia de Coronel Portillo de la ciudad de Pucallpa, constando con una muestra representativa  de veintidós familias a conveniencia del investigador y que pertenecen en calidad de estudiante de la Universidad Nacional Intercultural de la Amazonía. Se aplicó la observación y entrevista como técnica, además sus instrumentos como la ficha de observación y ficha de entrevista permitió identificar su conocimiento, tratamiento y prevención del dengue. Resultados. La mayoría de los pobladores conocen la forma de propagación, tratamiento y los cuidados de esta plaga que existe en la Amazonía, en consecuencia, el dengue es una enfermedad que afecta la salud de la población de la selva peruana, la detección y la intervención tardía en los pacientes complica la vida, por ello, optan a diversas alternativas para su tratamiento, prevención y para no propagación se utiliza conocimientos ancestrales y científicas. Conclusiones. El dengue es una enfermedad que se propaga rápidamente en las regiones donde hay presencia de zancudo, su complicación puede terminar en un derrame y fallecimiento en los pacientes de alto riesgo
Marché au bois en ville, en France, à l'époque moderne : quelques remarques
Authors: Boissiere Jean
Published: August 2023

La notion de marché au bois n'est pas très facile à cerner, au sens strict du terme, c'est-à-dire un lieu public désigné comme tel et où se négocie, dans le cadre urbain, le produit des coupes forestières. A l'époque moderne on trouve plus couramment dans la nomenclature des références au marché à grains, aux chevaux, à la viande, voire aux herbes mais ce n'est qu'exceptionnellement que l'on désigne les lieux de vente des bois par l'expression de marché. Pourtant il y a là, au XVIIIe siècle notamment, un secteur qui prend de plus en plus de place dans la satisfaction des besoins des populations. La demande en bois de chauffage, pour ne parler que de lui, ne cesse de grandir et elle s'accompagne de préoccupations croissantes de la part de ceux qui cherchent à y répondre, marchands ou échevins, dont celles de l'acheminement et du stockage ne sont pas les moindres. Le second, notamment, fait appel à des ports et des chantiers qui, l'exemple parisien en témoigne abondamment, peuvent devenir, pour peu que la tension monte en ville, des lieux de contestation sinon de violence. C'est que, comme pour les grains, volumes et prix doivent être sous contrôle plus ou moins apparent selon l'importance des enjeux et, notamment, de la clientèle à satisfaire.
Le bois dans les constructions de la ville médiévale : les questions
Authors: Pesez Jean-Marie
Published: August 2023

Uses of wood in construction are numerous and varied : for framework walls, partitions, roofing, flooring, window openings, plinths, wall coverings, and also enclosures, roads, somtimes ramparts, and in ports, for pontoons and quais.

Even in countries where construction was done exclusively with stone, wood was necessary for the skeletal structure. The carpenter's work seems to have made progress in the Middle Ages, bvt this progress came perhaps rather late. The triangulated form was not put to use until the very end of the Middle Ages. Dendochronology should allow us to verify this assertion.

The place of wood in domestic constructions also brings up certain questions. Wood is the material of preference in Slavic villages, at least in the forestry zones of Northern Europe. However, in the mediterranean region, texts up to the 13th C. only mention material if stone is used and then only if wood is used. Archeology invites us to devote attention to the place of wood in the 13th C.

In the Western world, proof from the high Middle Ages is not abundant ; when it does exist, it evokes, pole/post armature for houses and wicker-work surfaces. Does stone then later replace wood ? Etoubtless this is true, but wood makes a come-back at the end of the Middle Ages, with the wood panel technique.
La déduction de la loi divine et les stratégies discursives de Spinoza
Authors: Matheron Alexandre
Published: August 2023

Spinoza, dans la déduction de la loi divine qu'il nous donne au chapitre 4 du T. T. P., établit que le Souverain Bien consiste dans la connaissance intellectuelle de Dieu, elle-même identifiée à la connaissance intellectuelle des choses. Les deux démonstrations de cette thèse (une longue en trois étapes et une courte) sont exotériques dans la mesure où, sans rien affirmer qui soit contraire à la pensée de Spinoza, elle peuvent recevoir, à côté de leur sens spinoziste, un sens qui les rende acceptables pour les philosophes non-spinozistes. Mais elles sont aussi ésotériques dans la mesure où elles indiquent aux non-spinozistes philosophes comment il est possible de fonder rationnellement les quatre premiers dogmes du Credo minimum exposé au chapitre 14, que les non-spinozistes non-philosophes ne peuvent accepter à titre d'articles de foi. Cet article analyse en détail les procédés employés par Spinoza pour obtenir ces deux résultats.
Hegel et le scepticisme
Authors: Lécrivain André
Published: August 2023

Hegel's Relation of Scepticism to Philosophy was published in the Critical Journal of Philosophy (which appeared from 1801 to 1803). Concern with assessing the place of scepticism is a permanent feature of Hegel's thought in the presentation of his own system. Scepticism is a capital moment in the history of self-consciousness, insofar as it represents two determinations of any dialectical thought - that of the finite and that of the negative. Sceptical consciousness is aware of being self-negating and goes through an apprenticeship similar to that of the servant. It makes the contradictory, dialectical process that drives the history of spirit explicit. This is why scepticism should not be reduced to mere relativism. Thought must move from phenomenological analysis to speculative analysis in order to understand the true meaning of scepticism. Scepticism would thus seem to be a moment in the development of the Idea. Scepticism would be one of the privileged witnesses to the upheaval characteristic of Hegelian philosophy itself : it cannot contain either a fixed body of doctrine or conventional modes of thought.
Pandafilando de la Fosca Vista, un monstre dans le Don Quichotte
Authors: Campan Hélène
Published: August 2023

In der Herberge des Juan Palomeque (I, 29-1, 35) schlägt Don Quichotte auf die Bitte der Prinzessin Micomicona hin dem Ungeheuer Pandafilando de la Fosca Vista den Kopf ab. Dieser schielende Riese mit dem fürchterlichen Blick ist eine primitive und burleske Darstellung der Medusa-Gestalt : Ebenso wie diese besteht dieses Ungeheuer nur aus einer «testa», einem Kopf rund wie ein Wein-oder Wasserschlauch, der seinen Inhalt von sich gibt. Sancho Panza ist der einzige Augenzeuge dieser Heldentat, die Don Quichotte nach dem Vorbild von Therese, der Bezwingerin der Medusa, vollbringt. Allerdings geht er nicht nach der von Therese angewandten List vor, sondern vielmehr unter der Wirkung einer dionysischen Raserei. Das Abenteuer mit Pandafilando de la Fosca Vista erlaubt es, im «Don Quichotte» unter dem parodistischen Diskurs der Ritterromane und -legenden einen weiteren sagenhaften Diskurs auszumachen, der ebenfalls parodiert wird : jenen der griechischen Literatur, bei dem die Gestalten des Minotaurus, der Medusa und des Dionysos am deutlichsten hervortreten.
Monstruosité et reproduction, quelques remarques à propos de La serrana de la Vera de Luis Vêlez de Guevara
Authors: Aranda Maria
Published: August 2023

La serrana hispánica, sanguinaria y varonil, ha sido estudiada en función de sus múltiples identidades, folclóricas y literarias. Al convertirse para el teatro, en La serrana de la Vera de Vélez de Guevara, en la organizadora monstruoso y especular de toda una arquitectura dramatúrgica, el personaje pone a sus interlocutores ante su propria precariedad. Frente a los Reyes Católicos, a los militares arrogantes a los campesinos necios, ella encama el doble peligro de un regreso al magma inicial y de una extinción genealógica.
Investigating the Effect of Dust on the Rate of Photosynthesis and Air Pollution Tolerance Index of the Leaves of Ziziphusspina-christi (L.) Willd. in the City of Ahvaz
Authors: Kariminezhad Zhaleh , Attar Roshan Sina , Sabzalipour Sima , Mohammadi Rouzbahani Maryam , Shirvany Anoshirvan
Published: August 2023

Background & Aims: Dust is one of the phenomena affecting the environment’s quality. The change in the vital indices of plant species is one of its important effects. The present study was conducted to investigate the effect of dust on the rate of photosynthesis and air pollution tolerance index (APTI) of the leaves of Ziziphus spina-christi (L.) Willd. in the city of Ahvaz in 2020. Materials and Methods: A number of 10 Z. spina-christi (L.) Willd. trees were selected in each municipal district of Ahvaz metropolis. From each tree, one leaf sample was selected in the 4 main geographical directions, i.e., 4 samples from each tree species; overall, 40 leaf samples were collected in the whole region and sent to the laboratory to investigate the level of dust particles deposited in the four seasons of the year. Photosynthesis was measured based on the amount of chlorophyll by a spectrophotometer, and the APTI was calculated using Agbaire et al.’s method. Results: The results of measuring the weight of dust deposited on the leaves of Z. spina-christi (L.) Willd. trees in the city of Ahvaz showed that the greatest amount of dust was deposited on the leaves in the geographical north direction. The highest rate of photosynthesis was in the fall (53.76), and the lowest was in the spring (35.97). The mean APTI score of Z. spina-christi (L.) Willd. species in Ahvaz was 4.77. Conclusion: These results indicate that this species has a favorable APTI against environmental pollutants, including dust. In general, the results of the present study confirm the significant association of the dust deposited on the leaves of Z. spina-christi (L.) Willd. with the rate of photosynthesis and the APTI.
Utah Mining 2022 - Metals, Industrial Minerals, Uranium, Coal, and Unconventional Fuels
Authors: Rupke Andrew , Mills Stephanie E. , Vanden Berg Michael D. , Boden Taylor
Published: August 2023

The estimated combined value of Utah’s extractive resource production in 2022 totaled approximately $10.4 billion, including production of metals and industrial minerals ($4.2 billion), natural gas and natural gas liquids ($2.0 billion), crude oil ($3.6 billion), and coal ($504 million).
Cognitive and Neuropsychological Disorders in Patients with Multiple Sclerosis: A Focus on Verification and Diagnosis of Poorly Recognized Disease Symptoms (A Literature Review)
Authors: Федулов А.С. , Благочинная К.В. , Борисов А.В.
Published: August 2023

В статье представлена эволюция понимания диагностической и прогностической значимости когнитивных (КН) и нейропсихологических нарушений (НПН) у пациентов с рассеянным склерозом (РС) и обоснование рассмотрения их в качестве самостоятельной составляющей клинического диагноза. Проводится оценка клинических проявлений КН и НПН и вопросов применения различных методов их выявления. Как показывает анализ литературных данных, наиболее частыми, мало распознаваемыми симптомами РС являются когнитивная дисфункция, усталость / повышенная утомляемость и депрессия. Полное нейропсихологическое исследование позволяет с высокой степенью достоверности выявить клинические особенности КН у конкретного пациента, мониторировать их состояние как в случае естественного течения заболевания, так и в условиях применения того или иного варианта (медикаментозная терапия, когнитивная реабилитация) их коррекции. Важным компонентом диагностического процесса является сопоставление клинических и нейровизуализационных данных. Представлены данные о влиянии болезнь-модифицирующей терапии РС на основные проявления КН и НПН, описаны современные технологии когнитивной реабилитации с учетом результатов проведенных доказательных исследований. В качестве иллюстративного материала приводится предварительная оценка собственных когортных исследований КН/НПН в белорусской популяции.

The article presents the evolution of understanding of cognitive impairment (CI) and neuropsychological disorders (NPD) diagnostic and prognostic significance in patients with multiple sclerosis (MS) and substantiates their consideration as an independent component of the clinical diagnosis. Clinical manifestations of CI and NPD are evaluated, and the application of various methods for their detection is discussed. As the analysis of the literature data shows, the most common and poorly recognized symptoms of MS are cognitive dysfunction, fatigue and depression. A complete neuropsychological examination allows identifying with a high degree of reliability clinical features of CI in a particular patient, monitoring their condition both in the case of a natural course of the disease and in conditions of application of one or another option (drug therapy, cognitive rehabilitation) of their correction. Comparing clinical and neuroimaging data constitutes an important component of the diagnostic process. Data on the impact of MS disease- modifying therapy on the main manifestations of CI and NPD are presented, and modern technologies of cognitive rehabilitation are described taking into account the results of evidence-based studies carried out. As illustrative material, a preliminary estimation of own cohort CI/NPD studies in the Belarusian population is presented.
Dystrophic Myotonia: A Literature Review
Authors: Рушкевич Ю.Н. , Мальгина Е.В. , Гусина А.А. , Лихачев С.А. , Ходулев В.И. , Григорович Т.В. , Корбут Т.В. , Брант Е.В.
Published: August 2023

Дистрофическая миотония – наследственное мультисистемное нервно-мышечное заболевание, основные клинические проявления которого включают не только миотонию и прогрессирующую мышечную дистрофию, но и патологию со стороны других органов и систем. Является наиболее распространенной формой мышечной дистрофии у взрослых. Распространенность дистрофической миотонии широко варьирует в зависимости от возраста, численности населения, континентов, источников данных и критериев диагностики. Характеризуется медленно прогрессирующим течением с высокой частотой инвалидизации у детей и лиц трудоспособного возраста. В настоящей работе представлен обзор литературы с описанием наиболее частых клинических форм дистрофической миотонии, особенностей медико-генетического исследования и дифференциальной диагностики. Также рассматриваются вопросы симптоматического лечения и перспективы патогенетического лечения данного заболевания. Ведение пациентов с дистрофической миотонией требует междисциплинарного подхода к диагностике, наблюдению и симптоматической терапии.

Dystrophic myotonia is a hereditary multisystem neuromuscular disease whose main clinical manifestations include myotonia and progressive muscular dystrophy as well as pathologies of other organs and systems. It is the most common form of muscular dystrophy in adults. The prevalence of myotonia dystrophica varies widely depending on age, population size, continents, data sources, and diagnostic criteria. It is characterized by a slowly progressive course with a high incidence of disability in children and working age individuals. This paper presents a literature review describing most common clinical forms of dystrophic myotonia, features of medical genetic testing and differential diagnosis. The issues of symptomatic treatment and prospects of pathogenetic treatment of this disease are also considered. The management of patients with dystrophic myotonia requires an interdisciplinary approach to diagnosis, observation and symptomatic therapy.
The planned TEN-T railway corridor "Baltic Sea - Black Sea - Aegean Sea" as an opportunity for economic development of Eastern Poland
Authors: Dąbrowski Adam , Kruk Robert , Ochociński Krzysztof
Published: August 2023

Abstract: The article describes the basic requirements for the railway infrastructure of the comprehensive, extended core and core TEN-T network resulting from the draft of a new regulation of the European Parliament and of the Council (EU) on this matter. Then, the proposed TEN-T corridor “Baltic Sea – Black Sea – Aegean” is presented, which route is to lead largely through eastern and south-eastern Poland. This corridor, along with its considered link with the “Rail Baltica” route, fits well with the concept of the so-called eastern main line. The condition for creation of the corridor and the link is to ensure technical and operational parameters in accordance with the TEN-T requirements on the sections of railway lines included in their route, therefore the article assesses, what scope of investment works is related to the achievement of this goal and what adjustments and optimization measures should be considered. The creation of the corridor with the link may increase the transport accessibility of Polish regions located within their range of influence, and thus contribute to the economic development of these regions. Key words: accessibility, railway infrastructure