bluuebunny/crossref_metadata_2025 huggingface dataset:
Hydrazones derived from natural aldehydes: in vitro cytotoxic evaluation and in silico pharmacokinetic predictions
Authors: Dos Anjos Santos Victória Laysna , De Assis Gonsalves Arlan , Souza Silva Maria Franciele , Evangelista de Oliveira Fátima de Cássia , Pinheiro da Costa Marcília , Pessoa Claudia O. , Araújo Cleônia Roberta Melo
Published: May 2023

Introduction: Recent research has reported the cytotoxic potential of hydrazones against various strains of cancer cells. Aim: To evaluate the anticancer activity in vitro and the pharmacokinetic profile of six synthesized hydrazonic compounds, identified as vanillin 1-phthalazinylhydrazone (VAN-1); 2,4-dinitrophenylhydrazone vanillin (VAN-2); phenylhydrazone cinnamaldehyde (CIN-1); isonicotinoyl hydrazone cinnamaldehyde (CIN-2); cinnamaldehyde 1 phthalazinylhydrazone (CIN-3); and 2,4 dinitrophenylhydrazone cinnamaldehyde (CIN-4). Thecytotoxic activity was evaluated against four strains of cancer cells. Methodology: Thepharmacokinetic parameters of absorption, distribution, metabolism, excretion, and toxicity (ADME/T) of the hydrazones were evaluated using the PreADMET program. Results: Hydrazones derived from cinnamaldehyde (CIN-1 and CIN-2) showed high cytotoxic activity against leukemic (HL-60) and glioblastomas (SF-295) cell lines. The pharmacokinetic profile of the hydrazones showed that, in general, the hydrazones presented satisfactory characteristics of ADME/T. In addition, it was observed that CIN-2 presented the most promising in silico profile, showing high intestinal absorption, desirable distribution profile related to plasma protein binding, adequate renal excretion, and low toxicity. The ADME/T profile of the CIN-1 compound highlighted its potential as a promising antineoplastic agent with action of the CNS, more specifically against glioblastomas.
Main laboratory methods used for the isolation and identification of Staphylococcus spp.
Authors: Fernandes Queiroga Moraes Gustavo , Vilar Cordeiro Laísa , de Andrade Júnior Francisco Patricio
Published: May 2023

Introduction: Laboratory diagnosis related to clinical microbiology is highly complex, due to subjectivity when interpreting the results. Among bacterial pathogens, those linked to the Staphylococcus genus are relevant from a clinical and epidemiological point of view. Aim: To review the literature relative to the main laboratory methods used for the isolation and identification of microorganisms of the genus Staphylococcus. Methodology: The study was based on a literature search between 2000 and 2020, in the BVS, PubMed, Scielo, ScienceDirect and CAPES Periodical databases. Regarding its laboratory diagnosis, microscopy is used by the Gram method to verify the bacterium’s morphology; novobiocin test, aiming to trace coagulase negative strains; use of biochemical tests, such as coagulase and catalase tests; identification through the use of selective and nonspecific culture media, such as blood agar (in which the hemolytic patterns of pathogens are observed), salty mannitol agar (specific to the species of Staphylococcus aureus) and DNAse agar (selective to S. aureus strains , S. intermedius and S. hyicus). Results: The Staphylococcus genus is of great clinical importance in the field of public health. Thus, the quality and speed of diagnosis are essential to promote measures to combat these pathogens, contributing to the well-being and survival of those affected.
A descrição matemática da determinação eletroanalítica do fármaco salvarsan e seus ciclo-oligômeros, auxiliada pela composição do corante esquaraína com oxihidróxido de cobalto
Authors: Tkach Volodymyr V. , Kushnir Marta V. , G. Ivanushko Yana , De Oliveira Sílvio C. , Vaz dos Reis Lucinda , Yagodynets´ Petro I. , Kormosh Zholt O.
Published: May 2023

Objetivo: neste trabalho, a avaliação teórica da detecção eletroanalítica do antissifilíticosalvarsan é feita pela primeira vez. O oxihidróxido de cobalto em um compostocom o corante esquaraína é usado como modificador de eletrodo. Metodologia:por meio da análise de estabilidade é confirmada a eficiência da determinação desalvarsan. A linearidade da dependência entre o parâmetro eletroquímico e a concentraçãodo fármaco é facilmente obtida e mantida. Conclusão: as instabilidades oscilatóriase monotônicas são percebidas neste sistema, sendo causadas pelas influênciasdos estágios eletroquímicos sobre a dupla camada elétrica (DEL).
Caracterização físico-química, fitoquímica e avaliação da eficácia antimicrobiana de um gargarejo fitoterápico
Authors: Freitas Laura Christina , De Cabral Sobreira Ana Laura , de Andrade Júnior Francisco Patricio , Santos Carmo Egberto , Pereira de Souza Júlia Beatriz
Published: May 2023

Objetivo: considerando a importância dos produtos naturais de uso tradicional, o trabalho propôs a avaliação de parâmetros de qualidade e atividade antimicrobiana in vitro do gargarejo produzido no Centro de Educação Popular (Cenep), Nova Palmeira (PB), e utilizado para o tratamento de afecções da orofaringe e amígdalas. Metodologia: três amostras de gargarejo foram analisadas para avaliar o aspecto microbiológico sendo realizada a contagem de micro-organismos viáveis, por semeadura em profundidade. Materiais e métodos: a avaliação da atividade antimicrobiana in vitro contra S. pyogenes foi realizada utilizando o método de difusão em ágar e os parâmetros físico-químicos determinados foram pH, resíduo seco, densidade, bem como a caracterização fitoquímica. Resultados: apresentaram contagem microbiana dentro dos limites estabelecidos pela Farmacopeia. A atividade antimicrobiana contra S. pyogenes apresentou halos de inibição variando de 10,5 a 18,6 mm para amostra diluída e pura, respectivamente. Os parâmetros físico-químicos apresentaram pH 4,39 ± 0,16; o resíduo seco de 13,4 % a 15,4%; e a densidade de 1,013 ± 0,010. O perfil fitoquímico foi caracterizado pela presença de taninos, alcaloides e flavonoides. Conclusões: o gargarejo apresentou-se adequado para uso, tendo em vista os parâmetros microbiológicos, físico-químicos, fitoquímicos apresentados, bem como a comprovação da eficácia antimicrobiana adequada ao uso terapêutico proposto.
Prediction of sulfamerazine and sulfamethazine solubility in some cosolvent mixtures using non-ideal solution models
Authors: Tinoco Luz Elena , Galindres Diana M. , Osorio Jhonny , E. Cárdenas Rossember
Published: May 2023

Introduction: Experimental Solubilities of sulfamerazine (SMR) and sulfamethazine (SMT) in some (methanol + water), (ethanol + water) and (1-propanol + water) cosolvent mixtures were collected from the literature at five temperatures from 293.15 to 313.15 K. Methodology: The results were analyzed with the van’t Hoff, Apelblat modified, Buchowski-Ksiazaczak λh, van’t Hoff-Yaws model, twoparameter Weibull function model. It was determined that the models that best describe the solubility of these sulfonamides in (alcohol + water) mixtures were thevan’t Hoff and Apelblat models, obtaining correlation indices greater than 0.99 in all cases. Results: The results obtained with the Modified Apelblat equation presents ahigh correlation index for the solubility of SMR and SMT in cosolvent mixtures, followed by the van’t Hoff-Yaws model that presents a high fit of the estimated data with respect to the theoretical ones. According to the two parameter Weibull function model, the solubility of SMR and SMT in the co-solvent mixtures shows important deviations from ideality, which is consistent with the literature. The results are discussed in terms of the solute-solvent interactions that occur in this system.
Desarrollo tecnológico e introducción del inyectable succinilcolina 50 mg/mL en el cuadro básico de medicamentos nacional de Cuba
Authors: Burguet-Lago Nancy , Troche-Concepción Yenilen , Baró-Rodríguez Leisy , Martínez-Betancourt María Victoria , Toledo-Carrabeo Griset
Published: May 2023

Introducción: el inyectable succinilcolina 50 mg/mL se utiliza para intubaciones traqueales rápidas. Objetivo: desarrollar e introducir el inyectable succinilcolina 50 mg/mL en el cuadro básico de medicamentos. Tres variantes de formulación fueron diseñadas: dos con preservantes antimicrobianos y presentación (bulbos 6R y 10R) y una sin preservantes (bulbos 6R). Metodología: se validaron los métodos empleados para el control de calidad y estabilidad. A los lotes elaborados a escala de laboratorio, piloto e industrial con la fórmula seleccionada se les realizó estudio de estabilidad acelerada y vida útil. Las variantes diseñadas evidenciaron adecuada calidad, la no preservada fue seleccionada para realizar lotes a diferentes escalas. Las técnicas cromatográficas empleadas para la cuantificación de la succinilcolina cumplieron con los criterios de validación establecidos. Resultados: se demostró el desempeño de las pruebas de esterilidad y ensayo de endotoxinas bacterianas. El producto en estudio de estabilidad indicó un adecuado comportamiento físico, químico y microbiológico durante el período evaluado. Se comprobó la factibilidad del desarrollo tecnológico, con la fórmula seleccionada para el inyectable succinilcolina 50 mg/mL. Se introdujo el inyectable en el cuadro básico de medicamentos nacional.
Restorative justice as diversion for adult offenders in Queensland, 1990–2021
Authors: Price Stephanie , Prenzler Tim , McKillop Nadine , Rayment-McHugh Susan
Published: May 2023

This article provides a summary history and critique of the Queensland experience of restorative justice for adult offenders, with a focus on policy development and program implementation. It aims to identify key lessons to improve policy and implementation that may be transferrable to similar jurisdictions. Public source material was analysed to identify significant moments of change, including the launch of programs, the political rhetoric and commentary, as well as key activity data (e.g. referral rates). Results identified a significant lack of program uptake, with limited referral rates hindering the utilisation of restorative justice as an effective diversionary mechanism for adult offending in Queensland. In terms of both diversion and prevention, the study was restricted by a lack of data, indicating a significant practice and research gap, hence the need for enhanced research, increased application and greater transparency. Combined with a review of the literature, the results suggest the need for a greater focus on the welfare needs of victims and offenders to improve client and program outcomes, and reduce reoffending.
39 Juliet Street, Mackay
Authors: Moore Clive
Published: May 2023

My earliest memories are of 39 Juliet Street, Mackay. The house was built in the 1920s, my parents bought it in 1949 and it was sold after my father’s death in 1998. I have positioned the house within the environment and architecture of North Queensland, and particularly the town of Mackay. Changes are illustrated and dated through the inclusion of some family photographs, which double as a pictorial history of a Queensland family between the 1950s and 1970s. We all think of ourselves as part of families, but when one house contains a family over decades, it too is part of the upbringing. The essay begins with a discussion of North Queensland houses – ‘Queenslanders’, as they were known – and the weather conditions that influenced their architecture. This is followed by a description of the house and its immediate neighbourhood, the uses made of the upstairs and the downstairs areas, and 1960s renovations. My parents are described, along with our means of transport, the Protestant–Catholic divide of the 1950s and 1960s, and my upbringing and that of my brother and sister. The article also discusses holidays, schooling and discovering the world beyond Mackay.
EFFECTS OF HOLDING TIME ON MICROSTRUCTURE AND SHEAR STRENGTH OF RESISTANCE SPOT-WELDED JOINTS BETWEEN MILD STEEL AND ALUMINUM WITH ZINC POWDER FILLER
Authors: Hendrawan Muhammad Alfatih , Ilman Kholqillah Ardhian , Kunimine Takahiro
Published: May 2023

This study aimed to determine effects of holding time on microstructure and shear strength of resistance spot-welded joints between mild steel and aluminum with zinc powder filler. The materials used are 0.9 mm thick mild steel, 1.2 mm thick 3000 series aluminum, and 200 mesh zinc powder. Welding parameters were selected as welding time of 0.5 seconds (s), electric currents of 8000 and 9000 A, with
holding time variations of 1, 3, and 5 s. Macro and scanning electron microscope (SEM) images follow ASTM E3-01, while ASME IX was used as tensile test standards. The macro images showed that holding time affected quality of the welded joints. Applying a longer holding time was able to reduce defects on the welded joints. SEM energy-dispersive X-ray spectroscopy (SEM-EDX) analysis exhibited that
the holding time of 1 s produced a lack of density in the spot-welded joint, resulting in the existence of
porosity. In contrast, increasing the holding time to 5 s gives a denser spot-welded joint with no defects found. The tensile test results showed that applying electric current of 8000 A, welding time of 0.5 s, and holding time of 1 s produced the joint with the weakest shear strength of 130 N. The highest joint shear strength of 790 N is obtained with the condition: electric current of 9000 A, welding time of 0.5 s, and holding time of 5 s.
The Mutational and Transcriptional Landscapes of Speckle-Type POZ Protein (SPOP) and Androgen Receptor (AR) in a Single-Center pT3 Prostatectomy Cohort
Authors: Eryilmaz Isil Ezgi , Vuruskan Berna Aytac , Kaygisiz Onur , Cecener Gulsah , Egeli Unal , Vuruskan Hakan
Published: May 2023

Prostate cancer (PCa) is a heterogeneous disease both clinically and genetically. According to The Cancer Genome Atlas (TCGA), the speckle‑type POZ protein (SPOP) mutant form is one of the significant core subtypes of PCa. However, the prognostic value of SPOP variations remains unknown. As a critical PCa driver and an SPOP-targeted protein, androgen receptor (AR) also plays a role in PCa initiation and progression. Thus, we aimed to analyze the mutational status of SPOP and AR with their transcriptional levels in a pathological stage 3 (pT3) prostatectomy cohort consisting of 89 Turkish PCa patients. Targeted sequence analysis and RT-qPCR were performed for SPOP and AR in the benign and malign prostate tissue samples. Our results introduced the two novel pathogenic SPOP variations, C203Y and S236R, in the BTB/POZ domain and a novel pathogenic variant in the ligand-binding domain of AR, R789W. Their predicted pathogenicities and effects on protein features were evaluated by web-based in silico analysis. The overall frequency of SPOP and AR variations for pT3 patients in our population was 3.4% (3/89) and 4.5% (4/89), respectively. The mutational results represented a possible subgroup characterized by carrying the novel variants in SPOP and AR in pT3 PCa patients. In addition to the significant clinicopathological parameters, the mutational results provide a better understanding of the molecular structure of pathologically advanced PCa in the SPOP and AR aspects.
Effect of visible light and ultraviolet light on the pathogenicity of entomopathogenic fungi to false codling moth, Thaumatotibia leucotreta (Lepidoptera: Tortricidae) larvae
Authors: Rossouw Sumarie , Mathulwe Letodi Luki , Malan Antoinette Paula , Stokwe Nomakholwa Faith
Published: May 2023

Entomopathogenic fungi (EPF) are effective and environment-friendly insect biological control agents. Ultraviolet (UV) light is known to have an effect on the survival of fungal conidia, and natural sunlight is potentially one of the most damaging factors undermining EPF persistence and pathogenicity. This study aimed to test the infection potential of an isolate of Beauveria bassiana and five Metarhizium species after exposure to different light treatments, on soil and leaf surfaces under laboratory and field conditions, using Thaumatotibia leucotreta (Lepidoptera: Tortricidae) as the test host. Conidia were exposed either to growth light alone, which emits the same visible light as the sun, but excluding UV light, or directly exposed to UV light for 12 h. The results indicated no negative effect on the infection potential of the conidia of most species tested. The conidia of the two Metarhizium pinghaense (5HEID and TH149) isolates showed the greatest tolerance to visible light and UV radiation exposure on both soil and leaf surfaces. Exposure of M. pinghaense isolates to visible light on soil surfaces showed pathogenicity of > 80% for both isolates, and of between 58% and 88% after exposure to UV light. On leaf surfaces, three Metarhizium isolates, M. pinghaense (5HEID and TH149) and M. majus (TH153) had > 90% pathogenicity following exposure to UV light, and M. pinghaense (TH149) and M. robertsii (6EIKEN) showed greater tolerance of > 70%, under laboratory conditions. However, the pathogenicity of the EPF isolates was very low in field trials, indicating that further trials on the use of formulations and adjuvants with the isolates are needed to improve long-term persistence and efficacy under field conditions.
The human gut fungiome: Role in physiology and detoxification
Authors: Gilles-Eric Seralini
Published: May 2023

The intestinal microbiota is an ecosystem where bacteria, archaea, viruses, and protists, are entangled, but not alone. We take microbiota as the bacterial community because, in many historical papers, the probes to detect other organisms in the intestine were rarely used. But in addition, unicellular fungi or yeasts do exist in microbiota, their assembly is called the mycome or fungiome, and it can reach the size and number of our human cells. The bacteria are far more numerous. For a long time, the whole was taken for a nest of pathogens, but in fact, yeasts adapted and evolved as symbiotic cells helping not only our digestion, but also angiogenesis, tissue growth, vitamin synthesis, and our nervous, endocrine, immune systems and even our detoxification system. Much of what we swallow is or will become fermented, like bread, cheese, or wine. Since the beginning of agriculture, our food is eaten lightly by microbiota including yeasts first in plants not treated by pesticides. Natural yeasts still unknown are in hundreds of types or species at the very least, bringing in particular during their work of fermentation a multiplicity of aromas that play a role in the famous detoxification; but the usual diet only provides a few strains of these yeasts. In yeasts like in all cells, ubiquitous cytochrome P450 detoxifying enzymes form a vast family also involved in cell respiration, which is stimulated to some extent by the aromas and other signals secreted. Yeasts could attract and coordinate bacteria to eliminate in part chemical pollutants.
HIS ALL-HOLINESS ECUMENICAL PATRIARCH BARTHOLOMEW І ON THE SPIRITUAL IMPERATIVES OF ORTHODOX THEOLOGY
Authors:   Taras Shevchenko national University of Kyiv, Predko Olena , Shashkova Liudmyla ,   Taras Shevchenko national University of Kyiv
Published: May 2023

The article notes that spirituality in Orthodoxy is understood actively, as spiritual life, as the experience of the church community. Moreover, the theological concept of spirituality of Bartholomew I unfolds on the following levels: etymological (spirituality is directly related to breathing, with the quality of a person, without which its existence is impossible); life-meaningful (contextual meanings, in which the process of combining the history of the concept with the history of discourse, their comprehension and rethinking in the transcendent dimension is traced); practical-spiritual (spiritual and preaching activity, the process of moral teaching, the organization of life in accordance with the "Christian science of life"). The relationship between spirituality and personality is emphasized (its components are mystery, freedom, relationship, integrity). Priority in the structural hierarchy of spirituality is the moral and ethical principle, which acts as an indicator. It determines the fullness of social and individual existence since morality is one of the main mechanisms not only for regulating relations but also for the "spiritualization" of a person, on which depends his existential experience. Attention is paid to religious practices, in particular prayer, its spiritual connotations. In the state of prayer, a person tries to build his "Self" to the level of the Other, but at the same time to remain himself. If in this goal-setting process he ceases to hear a response addressed to his unique self, in this case, the prayer loses its dialogical nature. It is emphasized that, according to Ecumenical Patriarch Bartholomew І, spirituality, firstly, acts as a way of God's activity; secondly, it is closely related to the level of development of mental life, of a certain culture of feelings; thirdly, spirituality is recognized as a value that is the property of spiritual freedom, in which the human, the individually unique is combined with the divine, the universal; fourthly, it is the crystallization of the ethical-value core and anthropological-communicative meaning of certain religious practices; fifthly, the "code of spirituality" permeates all spheres of human existence, in which a person is affirmed both existentially and individually.
Diagnostic Value of Slow Conduction Index in Differential Diagnosis of Wide QRS Complex Arrhythmias with Left Bundle Branch Block Morphology
Authors: Chmelevsky Mikhail P. , Budanova Margarita A. , Stepanov Danila A. , Zhabina Ekaterina S. , Tulintseva Tatiana E.
Published: May 2023

BACKGROUND: Differential diagnosis of arrhythmias with wide QRS complexes remains an unresolved problem in clinical practice. After decades of careful research, many different criteria and algorithms have been proposed, but many of them are not quite accurate and effective in real clinical conditions. One of the approaches is to use ECG to estimate the speed of propagation of excitation through the ventricular myocardium. The estimation is based on the ratio of the amplitudes of the initial and final parts of the QRS complex, in particular, using the slow conduction index.
AIM: To study the possibility of using the slow conduction index in the differential diagnosis of arrhythmias with wide QRS complexes and to carry out a detailed comparative analysis of the diagnostic value of this criterion in all 12 ECG leads with evaluation and comparison of the obtained values of diagnostic accuracy.
MATERIALS AND METHODS: The study included 280 single wide QRS complexes with a form of left bundle branch block (LBBB) detected during one-day and multi-day ECG monitoring in randomly selected 28 patients. For a detailed analysis, a comparison of the original 12-lead ECG and individual scalable ECG graphs for selected leads was carried out, followed by measurement of the absolute values of the total amplitudes during the initial and final 40 ms wide QRS complexes. For a qualitative and quantitative assessment of diagnostic significance, ROC analysis was used to determine the informative value of a diagnostic test based on sensitivity (Sn), specificity (Sp) and diagnostic accuracy (Acc).
RESULTS: According to the obtained values of Sn, Sp and Acc, all 12 leads were arranged in the following order as the diagnostic value of the slow conduction index decreased: aVL, V2, aVF, V5, III, V1, V4, II, aVR, V6, V3 and I. In the first six ECG leads, Acc was consistently above 90%, gradually decreasing in the next six leads from 89% to 67%, respectively (p 0.001 for all leads).
CONCLUSIONS: The results of this study showed that the slow conduction index can be used in any ECG leads as a criterion for the differential diagnosis of arrhythmias with wide QRS complexes with a form of LBBB. The study also demonstrated the importance of a comprehensive approach to the analysis of the form of the QRS complex and the need for a consistent detailed analysis of the existing criteria for the differential diagnosis of arrhythmias with wide QRS complexes in different clinical groups of patients.
Atrial Fibrillation Recurrence Rate in Different Clinical Groups: Coronary Artery Disease and Age Matter
Authors: Gorev Maxim  V. , Urazovskaya Irina L.
Published: May 2023

BACKGROUND: Catheter ablation (CA) is an established method for atrial fibrillation (AF) treatment. Up to 20% of patients with AF develop coronary artery disease (CAD) as a secondary diagnosis. The data on whether the CAD affects the efficacy of AF ablation is contrary, while arterial hypertension is a known risk factor for AF as well as for AF recurrence after the CA.
AIM: We conducted this research to assess the AF recurrence rate and its risk factors after the primary catheter AF ablation procedure in the different clinical groups including IdiopathicAF, AF concomitant to arterial hypertension (HTN) and AF concomitant to CAD.
MATERIALS AND METHODS: Patients who underwent 451 PVI procedures performed since January 2016 to December 2017 were screened for AH, CAD and other structural heart disease. Among them 153 pts were selected for the subsequent analysis and divided into 3 groups IdiopathicAF, AF + AH, AF + CAD.
RESULTS: The presence of CAD (r = 0.313, p 0.001), age (r = 0.224, p = 0.008), CHA2DS2-VASc score (r = 0.279, p = 0.001), history of MI (r = 0.240, p = 0.004), LA size (r = 0.204, p = 0.018) were correlated with the recurrence rate. In the AF + CAD group patients older than 65 years demonstrated dramatically lower AF-free survival rate (37.5%) in comparison to younger CAD population (75%, log-rank p 0.001) as well as to younger and older non-CAD patients.
CONCLUSIONS: The presence of CAD should always attract the attention of physicians before considering the AF ablation as an option to treatment. Elderly CAD patients have the lowest ablation efficacy and the best strategy for this group (more extensive primary ablation or conversion to the permanent AF) needs to be studied.
Pengaruh politik terhadap dinamika musik rock n roll di Malang Tahun 1959–1992
Authors: Prayogo Moh. Aldiansyah , Ayundasari Lutfiah
Published: May 2023

This article discusses political influence on the rock n roll music which began from 1959 till 1992. Rock n roll music entered Malang through Australian radio many people who liked rock n roll music. Soekarno acted decisively and began to seriously deal with anything that smelled of foreign culture entering big cities in Indonesia, one of which was Malang. Malang musicians made music in the Soekarno era by uniting Western music with nationalist lyrics. Differences in policy can be seen in the Suharto era facing this. In the 1960s Suharto began to hold a series of performances featuring music that was prohibited during the Guided Democracy. This had an impact and gave birth to famous musicians and bands in Malang such as Ian Antono and Sylvia Saartje. The people of Malang in 1970 were very critical of music, especially rock n roll music, Malang was dubbed the barometer of Indonesian rock music in the 1970s. This article aims to find out the policies of Soekarno and Suharto on the dynamics of rock n roll music in Malang in 1959-1992.

Artikel ini membahas tentang pengaruh politik terhadap Musik rock n roll yang dimulai pada tahun 1959-1992. Musik rock n roll mulai masuk di Malang melalui radio Australia dan tidak sedikit yang menyukai musik rock n roll. Melihat hal tersebut, Soekarno bertindak tegas dan mulai serius menghadapi apapun yang berbau budaya asing yang mulai masuk di kota-kota besar di Indonesia, salah satunya kota Malang. Musisi Malang bermusik pada era Soekarno dengan cara menyatukan musik Barat dengan lirik nasionalis. Perbedaan kebijakan dapat terlihat pada era Soeharto menghadapi hal tersebut. Pada dekade 1960-an Soeharto mulai mengadakan serangkaian pertunjukan yang menampilkan musik-musik yang dilarang pada masa Demokrasi Terpimpin. Hal tersebut berdampak dan melahirkan musisi dan band ternama di Malang seperti Ian Antono dan Sylvia Saartje. Masyarakat Malang tahun 1970 sangat kritis prihal musik terutama musik rock n roll, Malang di juluki barometer musik rock Indonesia pada tahun 1970-an. Artikel ini memiliki tujuan untuk mengetahui kebijakan Soekarno dan Soeharto terhadap dinamika musik rock n roll di Malang tahun 1959-1992.
Anthra­cycline-Induced Cardiotoxicity: the Role of Genetic Predictors
Authors: Kopeva K. V. , Grakova E. V. , Shilov S. N. , Popova A. A. , Berezikova E. N. , Neupokoeva M. N. , Ratushnyak E. T. , Teplyakov A. T.
Published: May 2023

Aim      To evaluate the predictive significance of gene polymorphism in endothelin-1 type 2A receptor, NADPH oxidase, p53 protein, endothelial nitric oxide synthase, caspase 8, interleukin-1β, tumor necrosis factor-α, superoxide dismutase-2, glutathione peroxidase-1, β1-adrenoceptor, angiotensin-converting enzyme, and matrix metalloproteinase-3 (MMP-3) genes in evaluating the risk of anthracycline-induced cardiotoxicity (AIC) in women without concurrent cardiovascular diseases (CVD).

Material and methods  This study included 176 women aged 45.0 [42.0; 50.0] years with breast cancer without concurrent CVD who were scheduled for polychemotherapy (PCT) with anthracycline antibiotics. Echocardiography was performed for all patients at baseline and at 12 months after the end of PCT course. Genetic polymorphism was determined with the polymerase chain reaction.

Results At 12 months, all patients were in remission of the underlying disease. They were retrospectively included into 2 groups: 1st group, 52 patients with AIC and 2nd group, 124 women without AIC symptoms. The development of AIC was associated with the presence of the p53 protein gene Arg / Arg genotype (odds ratio (OR), 2.972; p=0.001), NOS3 gene T / T genotype (OR, 3.059; p=0.018), NADPH oxidase gene T / T genotype (OR, 2.753; p=0.008), GPX1 gene C / C genotype (OR, 2.345; p=0.007), MMP-3 gene 5A / 5A genotype (OR, 2.753; p=0.008), and ADRB1 gene G / G genotype (OR, 3.271; p=0.043).

Conclusion      Evaluation of genetic polymorphism in p53 protein (rs1042522), NOS3 (rs1799983), NADPH-oxidase (rs4673), GPX1 (rs1050450), ADRB1 (Arg389Gly, rs1801253), and MMP-3 (rs3025058) genes can be recommended for use prior to starting chemotherapy in women with breast cancer without CVD for assessing the risk of AIC. A maximum risk of cardiotoxicity is associated with the presence of the p53 protein gene Arg / Arg genotype and NOS3 gene T / T genotype.
Physicochemical attributes and bioactive properties of statice leaves
Authors: Souza Alexandra Goede de , Jung Eduardo Affonso , Benedicto Vinícius Petermann , Bosco Leosane Cristina , Münch Daniela , Wasilkosky Gabrieli
Published: May 2023

Some ornamental plants have been receiving special attention, not only for their use in landscaping, but also because of their bioactive, aromatic and spicy properties. The objective of this study was to characterize physical and chemical attributes and antioxidant activity in leaves of three cultivars of statice (Limonium sinuatum). The cultivars used were QIS White, QIS Blue Dark, and QIS Yellow. The content of total soluble solids (TSS), total titratable acidity (TTA), TSS/TTA ratio, pH, vitamin C, anthocyanin, flavonoids, total phenolic compounds (TPC), total antioxidant activity (TAA) and the relationship between TPC and flavonoids and TAA were analyzed for each cultivar. The results showed that the leaves of the QIS White cultivar have a higher TSS/TTA ratio, indicating better flavor. The QIS White cultivar also showed higher vitamin C and flavonoid content. The cultivars QIS White and QIS Blue Dark showed higher TPC contents, but there were no differences in TTA and anthocyanin content. The average TAA values were 94.3%, indicating that all cultivars have a high capacity to sequester the DPPH radical. There was a positive relationship between TPC with flavonoids and TAA (R2=0.6168 and 0.8826, respectively). The leaves of statice plants, traditionally used in landscaping and as a cut flower, have potential for use in human food.
Non-parametric Measures for Yield Stability in Faba Bean (Vicia faba L.) Advanced Line in Gangetic Plains of India
Authors: Raiger H.L. , Jajoriya N.K. , Deewan Parvati , Yadav C.B. , Gill R.K. , Arya Rajesh , Verma Rajhans , Mehto J.L.
Published: May 2023

Background: Multi environmental trials (MET) is central activity in crop improvement programs for identification of superior genotype across environment before release as a variety. The aim of the present study was to select faba bean genotypes having high seed yield and most stable performance across different environments in gangetic plains of India. Methods: The material for the study consisted of set of 11 genotype of faba bean subjected to multi-locational seed yield trials for three years (2015-2018) at four locations. The test of significance for genotype x environment (GE) interaction and eight non-parametric measures of stability analysis were used to identify high yield stable genotype across the five environments. A new approach Combined Stability Index based on yield stability performance calculated based on the ranking of the used stability measures of all the genotypes. Result: Based on low value of Combined Stability Index, HB-12-37, (CSI(i) = 10) HB-11-15, (CSI(i) = 11), HB-11-32 (CSI(i) = 14) were identified as the most stable genotypes with high yield potential. These non-parametric measures were observed to be associated with high mean seed yield. The simple rank correlation coefficient, calculated using the ranks was used to measure the association among the eight stability statistics and mean seed yield. The nature of relationships among the non-parametric measures was assessed and these stability measures are categorized in three groups. The genotype HB-12-37 (G3) fall in section 1 were the most favourable genotype due to high seed yield as well as high stability performance according to plot of all non-parametric measures with seed yield. HB-12-37 (G3) which had higher seed yield (25.19 q / ha) and high protein content (24.85%) with better stability across the environments could be used in further breeding programmes of faba bean and recommended for release as variety for plains of India.
Uso de narrativas ficcionais na formação docente
Authors: Silva Fábio Luiz da , Jesus Adriana Regina de , Lima Claudia Maria de Sousa de
Published: May 2023

A qualidade da educação está diretamente relacionada à formação dos professores. Assim, o objetivo deste artigo é realizar uma reflexão sobre a possibilidade do uso de obras de ficção na formação docente, por meio do estudo da obra da escritora canadense Lucy Maud Montgomery. Neste artigo, priorizamos a questão da gestão da sala de aula. Para isso, utilizamos autores que discutem este tema e aqueles que pesquisam sobre a formação docente e a utilização da literatura e dos filmes na compreensão do trabalho docente. Analisamos os livros: Anne de Green Gables (2009) e Anne de Avonlea (2017). Além disso, estudamos episódios da série Anne with an E (2017-2019). Foi possível verificar a importância da reflexão crítica a respeito de como a gestão da sala de aula é apresentada em tais narrativas. Isto permite ir além da visão meramente prescritiva das narrativas sobre professores e partir para uma compreensão da complexidade do trabalho docente.
Radiación infrarroja y efecto invernadero
Authors: Martín Rodrigo Sebastián , Quiñonez Walter , LoPrete Daniel Vicente , Rossi Paula Vanesa
Published: May 2023

Introducción. El cambio climático es una de las realidades más complejas que aqueja a la población mundial. En particular, el aumento en el efecto invernadero producto de la desmedida emisión de gases parece ser el principal causante del calentamiento por actividad antrópica que genera estos cambios en los parámetros estándar que describen al clima terrestre. Objectivo y Metodología. En este contexto resulta menester que dichos conceptos se traten en contexto áulico, y que sean materias como física y fisicoquímica las que propongan un acercamiento a estos forzantes climáticos desde los procesos y no solo desde las repercusiones (como suele hacerse desde materias como biología y geografía). Resultados y Conclusión. Por esta razón, en el presente trabajo se propone una breve unidad didáctica que aborda los conceptos claves para entender el efecto invernadero como modelo didáctico. Buscase la construcción colectiva de dicho concepto a partir de pequeños experimentos y largas reflexiones.
Pathological and Molecular Investigation of Some Bacterial in the Lungs and Livers of Red Sokoto Goats Slaughtered at Ilorin, Kwara State, Nigeria.
Authors: Adam Mohammed , Akeem Ahmed Olayiwola , Barka Sanni Abdul , Olu Shoyinka Shodeinde Vincent , Abiodun Ajadi Abdullateef , Ola-Fadunsin Shola David
Published: May 2023

This study was conducted to determine the pathological findings and molecular investigation of bacteria flora associated with the lesions in the lungs and livers of goats slaughtered for public consumption at the Ilorin, abattoir. A total of 450 samples (240 lungs and 210 livers) were collected and examined from goats slaughtered at the Ipata slaughterhouse in Ilorin, Kwara State. Of this number, 58 (24.17%; 95% CI = 19.19–29.96) lungs and 17 (8.10%; 95% CI = 5.17–12.58) livers revealed gross and microscopic pathological lesions as a result of bacterial pathogens. Based on gross examination, lung lesions were categorized into bronchopneumonia (27.59%), congestion (22.41%), interstitial pneumonia (17.24%), hemorrhages (13.77%), emphysematous (10.34%), and hyperemia (8.62%). In the liver, hepatic congestion 8 (47.06%) was the most observed gross lesion. Others included hepatic enlargement (29.41), hepatic fibrosis (17.65%), and hepatic abscess (5.88%). The molecular investigation revealed lung pathological lesions were as a result of Klebsiella species (51.72%) and Bacillus species (48.28%), while Escherichia species (52.94%) and Salmonella species (47.06%) were detected in the liver. The molecular analysis showed that the bacteria organisms detected in this study did not fully cluster with similar species from other parts of the world. The infection caused by these bacteria showed histopathological lesions in the lungs and livers. There is need for more studies to further characterize these bacteria species detected from Red Sokoto breeds of goats in-depth.
Long Wave Induced Monopolar Vortex: Additional Large Eddy Simulation Case
Authors: Kim Yeulwoo
Published: May 2023

An additional 3D large eddy simulation with a slightly different surface tension coefficient is carried out to study the detailed flow and turbulence characteristics of a long wave induced shallow water monopolar vortex. The numerical model adopted in this study is interDyMFoam, developed based on an OpenFOAM framework. The numerical model solves filtered Navier-Stokes equations for two immiscible fluids (air, water) with a standard Smagorinsky closure. In addition to the previous model results, newly obtained instantaneous model results are used to increase a number of realizations for ensemble averaging to reach more statistically converged results. The validation quality obtained in this study is shown to be similar to that from the previous simulation results in the low-pass filtered free surface elevation and horizontal component of velocity.
Dinâmica da linha de costa no trecho de praia entre os municípios de Fortaleza e Paraipaba, Estado do Ceará, Brasil
Authors: Targino da Silva Maykon , Nogueira Lopes Debora , Viana Freires Eduardo , Ângelo da Silva Neto Cláudio , Vandesteen Silva Souto Michael , Romariz Duarte Cynthia
Published: May 2023

A erosão costeira é um problema recorrente em vários lugares no mundo, inclusive no Ceará, que possui no trecho de praia entre Fortaleza e Paraipaba notória importância socioeconômica, que necessita de estudos de longos prazos para compreender a dinâmica costeira nessa região. Assim, o presente artigo teve como objetivo analisar a evolução da linha de costa no trecho de praia entre Fortaleza e Paraipaba (1984-2020). Para isso, foram feitos: processamento digital de imagens; extração das linhas de costa; cálculos de variação da linha de costa; e, classificação e interpretação dos resultados. Na análise por períodos, no primeiro setor, a estabilidade e a acreção predominaram em dois períodos cada uma, respectivamente, 1984-1991 e 2000-2008, e, 1991-2000 e 2014-2020; já no segundo e terceiro setores a erosão prevaleceu, para ambos, em três períodos(1984-1991; 2000-2008; e, 2008-2014). Os trechos que tiveram uma dinâmica com respostas expressivas foram: i) os recuos da linha de costa na praia de Icaraí (Caucaia) e na foz do rio Curú (Paracuru); e, ii) a progradação no Porto do Pecém (São Gonçalo do Amarante). A análise por períodos foi relevante porque ela evidencia processos significativos que podem ser mascarados por outros métodos estatísticos, como a regressão linear
Peculiarities, Ecological and Economic Rationale of International Waste Trade in the Russian Federation
Authors: Karginova-Gubinova V.
Published: May 2023

Despite the low proportion of recycled waste against the total one generated in the Russian Federation, it is imported into the country specifically for recycling. At the same time some of the generated waste is exported. The purpose of this study is to assess the current waste export and import indicators in Russia and any dialectical and institutional constraints on increasing the rate of waste recycling, which determine the ecological and economic rationale of international waste trade operations. The main sources of data featured reports of the Federal Customs Service and the Federal Service for Supervision of Natural Resources, and the Unified Interdepartmental Statistical Information System and UN Comtrade databases. Econometric methods, cluster analysis of Russian regions, analysis of any regulatory impact and content analysis of laws and regulations were applied and carried out within the study. It is demonstrated that the external waste-related economic operations in the Russian Federation have certain peculiarities against other countries. Their being in place is driven by both dialectical and institutional factors. However, the actors’ opportunistic economic interests rather than the environmental ones and the extent of the country take the lead. Some tools to reduce the transaction costs of transboundary waste movement and to increase the waste management efficiency are proposed. The study is novel in that it analyzes the foreign waste trade transactions of Russia that have not been comprehensively studied before. The theoretical relevance of the research consists in its finding new factors that drive the transboundary waste movement. Recommendations on improving the export and import regulation, reducing the rate of waste generation and increasing the recycling one in Russia, which would both enhance the economic efficiency of companies and provide equitable solution to environmental problems faced by the country, are of practical value.
Crisis-Containing Factors of the PRC’s Development
Authors: Mikheev V. , Lukonin S.
Published: May 2023

In 2022–2023, China is entering a new stage of its development. The combination of a number of crisis-containing factors increases the likelihood of a large-scale socio-economic shock. Partly man-made excessive slowdown in economic development due to the “Zero COVID policy”, the ongoing and escalating US-Chinese rivalry and, in particular, the “technological war”, the over-concentration of power after the 20th Congress of the CPC, as well as the growing tension around the Taiwan problem – all together, or with the imposition of just two or three components, can lead to serious negative socio-economic consequences that will put into question Beijing’s achievement of its second “centennial goal” – the establishment of the PRC as one of the leading world powers by 2049. With the exception of the domestic political sphere, China is trying to find answers to the above-mentioned challenges. In late 2022 – early 2023, Beijing removes anti-coronavirus restrictions, activates trade and economic cooperation in various formats, attempts to find out common ground between Chinese and American global interests, continues to make efforts in the European (also African, Asian, etc.) direction of its foreign policy, as well as emphasizes the high level of Russian-Chinese cooperation. At the same time, trying to provide answers to crisis-containing factors, Beijing faces both opportunities and limitations. The coming year or two seem to be most difficult for China over the last 20 years. The slowdown in the economy and domestic consumption, social protests, new challenges of the pandemic, the search for options to normalize relations with the United States, balancing between the West and Russia against the background of the Ukrainian crisis, etc. will require non-standard solutions from the Chinese leadership. Here we can expect both traditional successes and possible failures. In the near future, the political model chosen by Beijing at the 20th CPC Congress will be tested for effectiveness.
On the Role of Europarties in the Formation of a Pan-European Political Space
Authors: Guseletov B.
Published: May 2023

The article analyzes the increasing influence of pan-European political parties (Europarties) and their factions in the European Parliament, as well as that of representatives of European civil society, on the formation of the pan-European political space, which is becoming an essential element of the European Union’s future political system. The main approaches to the theoretical understanding of the phenomenon of strengthening the pan-European political space landscape are described. It is shown that recently, the Europarties became the key agents of the Europeanization process, which has a significant impact on the formation of this landscape. The attitude of the EU political elite and representatives of European civil society to this development is considered. It is indicated that a serious impetus to further strengthening of the political space was given by the results of the European Parliament elections in 2019, following which the influence of Eurosceptic parties markedly increased. It is noted that the recently concluded Conference on the Future of Europe has adopted a number of important recommendations in support of reinforcing the “Spitzenkandidaten”-principle and the introduction of transnational lists at the EU elections, which should also strengthen the influence impact of European parties on the pan-European political landscape formation. Positions of the leading Europarties and their parliamentary groups in the EP regarding these proposals and the process of Europeanization in general are presented. It is demonstrated that a number of the European Council members representing liberal parties have explicitly stated the need to reform the EU political system as soon as possible in order to make it more monolithic and aimed at forming Europe as a geopolitical power.