bluuebunny/crossref_metadata_2025 huggingface dataset:
Location Reference Recognition from Texts: A Survey and Comparison
Authors: Hu Xuke , Zhou Zhiyong , Li Hao , Hu Yingjie , Gu Fuqiang , Kersten Jens , Fan Hongchao , Klan Friederike
Published: October 2023

A vast amount of location information exists in unstructured texts, such as social media posts, news stories, scientific articles, web pages, travel blogs, and historical archives. Geoparsing refers to recognizing location references from texts and identifying their geospatial representations. While geoparsing can benefit many domains, a summary of its specific applications is still missing. Further, there is a lack of a comprehensive review and comparison of existing approaches for location reference recognition, which is the first and core step of geoparsing. To fill these research gaps, this review first summarizes seven typical application domains of geoparsing: geographic information retrieval, disaster management, disease surveillance, traffic management, spatial humanities, tourism management, and crime management. We then review existing approaches for location reference recognition by categorizing these approaches into four groups based on their underlying functional principle: rule-based, gazetteer matching–based, statistical learning-–based, and hybrid approaches. Next, we thoroughly evaluate the correctness and computational efficiency of the 27 most widely used approaches for location reference recognition based on 26 public datasets with different types of texts (e.g., social media posts and news stories) containing 39,736 location references worldwide. Results from this thorough evaluation can help inform future methodological developments and can help guide the selection of proper approaches based on application needs.
Unraveling adipose tissue proteomic landscapes in severe obesity: insights into metabolic complications and potential biomarkers
Authors: Hruska Pavel , Kucera Jan , Kuruczova Daniela , Buzga Marek , Pekar Matej , Holeczy Pavol , Potesil David , Zdrahal Zbynek , Bienertova-Vasku Julie
Published: October 2023

This study provides insights into distinct proteomic profiles of subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT), and serum in patients with severe obesity and their associations with clinical traits and body composition. It underscores SAT’s crucial role in obesity development and related complications, such as insulin resistance (IR) and type 2 diabetes (T2D). Our findings emphasize the importance of understanding the SAT and VAT balance in energy homeostasis, proteostasis, and the potential role of SAT capacity in the development of metabolic disorders.
Differential effects of reward and punishment on reinforcement-based motor learning and generalization
Authors: Yin Cong , Li Biao , Gao Tian
Published: October 2023

Although reinforcement learning is a significant motor learning process, the mechanisms underlying how the brain learns movements through reward and punishment are not fully understood. We modified a well-established motor adaptation task and used savings (faster relearning) to measure generalization. We found reward led to slower learning but promoted generalization, whereas punishment led to faster learning but impaired generalization, suggesting that reward and punishment may engage different neural mechanisms during reinforcement-based motor learning and generalization.
Upregulation of miR‐20a‐5p as the Potential MicroRNA Marker in Red Blood Cell Storage Lesion
Authors: Rattanapan Yanisa , Narkpetch Sodsai , Chareonsirisuthigul Takol
Published: October 2023

Background. Packed red blood cells (PRBCs) can be preserved for 42 days, and stored PRBCs have slow, dangerous changes over time during storage. miRNA is approximately 22 nucleotides long, a small single‐stranded noncoding RNA molecule. miRNA guides by pairing bases with their downstream target mRNA to regulate negative expression. They are essential in many life processes, including cell differentiation, proliferation, and apoptosis. Therefore, miRNA alterations may represent possible biomarkers of PRBC storage lesions. This study is aimed at validating the miR‐20a‐5p in PRBC storage. Study Design and Methods. A total of 20 PRBC samples were divided into day 1 and day 20 storage groups. Total miRNA was extracted and quantified by probe‐based RT‐qPCR assays to explore the potential role of miRNAs in PRBC storage lesions. Results. Upregulated miR‐20a‐5p in PRBC storage on day 20 compared to day 1. MiR‐20a‐5p promoted cell survival, which may affect the downstream regulation and decrease PRBC viability in prolonged storage. Conclusion. On this basis, this detection may help to assess the quality of stored PRBCs.
Case of Accidental Trauma Resulting in Condylar Fractures in 3-Month-Old
Authors: Mouzourakis Maggie M. , Seo Sarah S. , Oral Resmiye
Published: October 2023

While mandibular fractures represent the most common craniofacial injury in the pediatric population, craniofacial fractures in infants are rare. Diagnosis is challenging with nonspecific presenting symptoms and often limited radiographic imaging. We report a case of nondisplaced mandibular condylar head fractures in a 3-month-old patient as a result of a fall with impact onto the chin, with associated sublingual hematoma (Coleman’s sign). Although the initially observed sole finding of sublingual hematoma raised concern for child physical abuse, detailed history, oral exam, and multidisciplinary review of radiologic records by pediatrics, otolaryngology, and child protection teams established the accidental trauma diagnosis. The patient was managed conservatively with normal resumption of feeding. Detailed history and multidisciplinary approach to the management of pediatric facial trauma are important in establishing diagnoses and management.
Modeling and Simulation Analysis of Bionic Flapping-Wing Flight Attitude Control Based on L1 Adaptive
Authors: Li Lun , Bai Fan , Wang Wencheng , Wu Xiaojin , Dong Yihua
Published: October 2023

Flapping-wing flight control is a multi-input and multi-output nonlinear system with uncertainties, which is affected by modeling errors, parameter variations, external disturbances, and unmodeled dynamics. Parameter uncertainty has a great impact on the stability control of flapping-wing flight, and gain adjustment is a common means to deal with parameter uncertainty, but it is complex and time-consuming. Based on the mechanism of flapping-wing flight, a nonlinear dynamic model for flapping-wing dynamic flight is established by analyzing the forces, moments, and attitude changes of the fuselage and wing in detail. Based on the constructed dynamic model, a fast robust adaptive flapping-wing flight control method is proposed. The state predictor is designed to estimate and monitor the uncertain parameters in the flapping-wing attitude control model, and the adaptive law adjusts the parameter estimation to ensure that the output error between the state predictor and the controlled object is stable in the Lyapunov sense, and finally the adaptive control law is obtained. At the same time, the Monte Carlo-support vector machine method is used to optimize the boundary of the control parameters in the flight control to obtain the control parameters that can meet the control expectations, and the obtained parameters are classified and judged according to the stable level flight conditions. Based on the adjusted parameters and the predetermined control signal, the control amount is adjusted according to the control law. When the adaptive gain is large enough, the simulation results show that the system has good transient response characteristics.
Supplementary Tables from Multimeric Anti-DR5 IgM Agonist Antibody IGM-8444 Is a Potent Inducer of Cancer Cell Apoptosis and Synergizes with Chemotherapy and BCL-2 Inhibitor ABT-199
Authors: Wang Beatrice T. , Kothambawala Tasnim , Wang Ling , Matthew Thomas J. , Calhoun Susan E. , Saini Avneesh K. , Kotturi Maya F. , Hernandez Genevive , Humke Eric W. , Peterson Marvin S. , Sinclair Angus M. , Keyt Bruce A.
Published: October 2023

Table S1 shows IGM-8444 VH and VL sequences and also shows that IGM-8444 did not cause serum liver enzyme elevation in monkeys. Table S2 shows synergy metrics for IGM-8444 plus other agents in combination and also shows IGM-8444 serum exposure in vivo.
Figure S5 from Multimeric Anti-DR5 IgM Agonist Antibody IGM-8444 Is a Potent Inducer of Cancer Cell Apoptosis and Synergizes with Chemotherapy and BCL-2 Inhibitor ABT-199
Authors: Wang Beatrice T. , Kothambawala Tasnim , Wang Ling , Matthew Thomas J. , Calhoun Susan E. , Saini Avneesh K. , Kotturi Maya F. , Hernandez Genevive , Humke Eric W. , Peterson Marvin S. , Sinclair Angus M. , Keyt Bruce A.
Published: October 2023

Figure S5 shows IGM-8444 efficacy in a gastric PDX model
Figure S3 from Multimeric Anti-DR5 IgM Agonist Antibody IGM-8444 Is a Potent Inducer of Cancer Cell Apoptosis and Synergizes with Chemotherapy and BCL-2 Inhibitor ABT-199
Authors: Wang Beatrice T. , Kothambawala Tasnim , Wang Ling , Matthew Thomas J. , Calhoun Susan E. , Saini Avneesh K. , Kotturi Maya F. , Hernandez Genevive , Humke Eric W. , Peterson Marvin S. , Sinclair Angus M. , Keyt Bruce A.
Published: October 2023

Figure S3 shows IGM-8444 induced cytotoxicity across a panel of cell lines
Figure S2 from Multimeric Anti-DR5 IgM Agonist Antibody IGM-8444 Is a Potent Inducer of Cancer Cell Apoptosis and Synergizes with Chemotherapy and BCL-2 Inhibitor ABT-199
Authors: Wang Beatrice T. , Kothambawala Tasnim , Wang Ling , Matthew Thomas J. , Calhoun Susan E. , Saini Avneesh K. , Kotturi Maya F. , Hernandez Genevive , Humke Eric W. , Peterson Marvin S. , Sinclair Angus M. , Keyt Bruce A.
Published: October 2023

Figure S2 shows IGM-8444 specificity for DR5
Supplementary Table S1 from Tumor-Targeted Nonablative Radiation Promotes Solid Tumor CAR T-cell Therapy Efficacy
Authors: Quach Hue Tu , Skovgard Matthew S. , Villena-Vargas Jonathan , Bellis Rebecca Y. , Chintala Navin K. , Amador-Molina Alfredo , Bai Yang , Banerjee Srijita , Saini Jasmeen , Xiong Yuquan , Vista William-Ray , Byun Alexander J. , De Biasi Andreas , Zeltsman Masha , Mayor Marissa , Morello Aurore , Mittal Vivek , Gomez Daniel R. , Rimner Andreas , Jones David R. , Adusumilli Prasad S.
Published: October 2023

List of antibodies and reagents used in this study
Supplementary Figures S1-S13 from Tumor-Targeted Nonablative Radiation Promotes Solid Tumor CAR T-cell Therapy Efficacy
Authors: Quach Hue Tu , Skovgard Matthew S. , Villena-Vargas Jonathan , Bellis Rebecca Y. , Chintala Navin K. , Amador-Molina Alfredo , Bai Yang , Banerjee Srijita , Saini Jasmeen , Xiong Yuquan , Vista William-Ray , Byun Alexander J. , De Biasi Andreas , Zeltsman Masha , Mayor Marissa , Morello Aurore , Mittal Vivek , Gomez Daniel R. , Rimner Andreas , Jones David R. , Adusumilli Prasad S.
Published: October 2023

Supplementary Figures 1-13 with associated legends
Supplementary Data from Cholesterol Efflux Drives the Generation of Immunosuppressive Macrophages to Promote the Progression of Human Hepatocellular Carcinoma
Authors: Li Zhixiong , Wang Yongchun , Xing Rui , Zeng Huilan , Yu Xing-Juan , Zhang Yao-jun , Xu Jing , Zheng Limin
Published: October 2023

Supplementary Figure S1-S5 and Table S1-S3
Figure 1 from Tumor Cell–Intrinsic c-Myb Upregulation Stimulates Antitumor Immunity in a Murine Colorectal Cancer Model
Authors: van Gogh Merel , Glaus Garzon Jesus F. , Sahin Dilara , Knopfova Lucia , Benes Petr , Boyman Onur , Jurisica Igor , Borsig Lubor
Published: October 2023

c-Myb upregulation reduces MC38 and B16-BL6 tumor growth in vivo. A, Immunofluorescence staining of c-Myb (red) in MC38T/O cells, treated for the indicated times with 1 μg/mL Dox in vitro. c-Myb staining is quantified as mean intensity per nucleus (white). Data are presented from two independent experiments, in duplicates. Each data point represents one cell. Scale bar, 50 μm. B–D, C57BL/6J mice were subcutaneously injected with 5 × 105 MC38T/O (B), 1 × 106 B16-BL6T/O (C), or 3 × 105 LLCT/O (D) cells and were fed control (Ctrl) or Dox containing chow for the duration of the experiment. Tumor growth, final tumor weight, and representative pictures are shown. n = 14 (B), n = 12 (C), or n = 5 (D) mice per group from three (A), two (B), or one (C) independent experiments. Data are presented as mean values ± SEM. One-way ANOVA with Kruskal–Wallis posttest was used for statistical analysis (A), two-way ANOVA was used for comparing tumor growth curves (B–D). **, P < 0.01, ***, P < 0.001, ****, P < 0.0001.
Supplementary Table S3 from Combinatorial Immunotherapy with Agonistic CD40 Activates Dendritic Cells to Express IL12 and Overcomes PD-1 Resistance
Authors: Krykbaeva Irina , Bridges Kate , Damsky William , Pizzurro Gabriela A. , Alexander Amanda F. , McGeary Meaghan K. , Park Koonam , Muthusamy Viswanathan , Eyles James , Luheshi Nadia , Turner Noel , Weiss Sarah A. , Olino Kelly , Kaech Susan M. , Kluger Harriet M. , Miller-Jensen Kathryn , Bosenberg Marcus
Published: October 2023

Supplementary Table S3
Supplementary Table S1 from Combinatorial Immunotherapy with Agonistic CD40 Activates Dendritic Cells to Express IL12 and Overcomes PD-1 Resistance
Authors: Krykbaeva Irina , Bridges Kate , Damsky William , Pizzurro Gabriela A. , Alexander Amanda F. , McGeary Meaghan K. , Park Koonam , Muthusamy Viswanathan , Eyles James , Luheshi Nadia , Turner Noel , Weiss Sarah A. , Olino Kelly , Kaech Susan M. , Kluger Harriet M. , Miller-Jensen Kathryn , Bosenberg Marcus
Published: October 2023

Supplementary Table S1
Supplementary Figures from Combinatorial Immunotherapy with Agonistic CD40 Activates Dendritic Cells to Express IL12 and Overcomes PD-1 Resistance
Authors: Krykbaeva Irina , Bridges Kate , Damsky William , Pizzurro Gabriela A. , Alexander Amanda F. , McGeary Meaghan K. , Park Koonam , Muthusamy Viswanathan , Eyles James , Luheshi Nadia , Turner Noel , Weiss Sarah A. , Olino Kelly , Kaech Susan M. , Kluger Harriet M. , Miller-Jensen Kathryn , Bosenberg Marcus
Published: October 2023

Figures S1-9
Data from Ncoa2 Promotes CD8+ T cell–Mediated Antitumor Immunity by Stimulating T-cell Activation via Upregulation of PGC-1α Critical for Mitochondrial Function
Authors: Zhong Xiancai , Wu Hongmin , Ouyang Ching , Zhang Wencan , Shi Yun , Wang Yi-Chang , Ann David K. , Gwack Yousang , Shang Weirong , Sun Zuoming
Published: October 2023

Abstract
Nuclear receptor coactivator 2 (Ncoa2) is a member of the Ncoa family of coactivators, and we previously showed that Ncoa2 regulates the differentiation of induced regulatory T cells. However, it remains unknown if Ncoa2 plays a role in CD8+ T-cell function. Here, we show that Ncoa2 promotes CD8+ T cell–mediated immune responses against tumors by stimulating T-cell activation via upregulating PGC-1α expression to enhance mitochondrial function. Mice deficient in Ncoa2 in T cells (Ncoa2fl/fl/CD4Cre) displayed defective immune responses against implanted MC38 tumors, which associated with significantly reduced tumor-infiltrating CD8+ T cells and decreased IFNγ production. Consistently, CD8+ T cells from Ncoa2fl/fl/CD4Cre mice failed to reject tumors after adoptive transfer into Rag1−/− mice. Further, in response to TCR stimulation, Ncoa2fl/fl/CD4Cre CD8+ T cells failed to increase mitochondrial mass, showed impaired oxidative phosphorylation, and had lower expression of PGC-1α, a master regulator of mitochondrial biogenesis and function. Mechanically, T-cell activation–induced phosphorylation of CREB triggered the recruitment of Ncoa2 to bind to enhancers, thus, stimulating PGC-1α expression. Forced expression of PGC-1α in Ncoa2fl/fl/CD4Cre CD8+ T cells restored mitochondrial function, T-cell activation, IFNγ production, and antitumor immunity. This work informs the development of Ncoa2-based therapies that modulate CD8+ T cell–mediated antitumor immune responses.
Data from Tumor Cell–Intrinsic c-Myb Upregulation Stimulates Antitumor Immunity in a Murine Colorectal Cancer Model
Authors: van Gogh Merel , Glaus Garzon Jesus F. , Sahin Dilara , Knopfova Lucia , Benes Petr , Boyman Onur , Jurisica Igor , Borsig Lubor
Published: October 2023

Abstract
The transcription factor c-Myb is overexpressed in many different types of solid tumors, including colorectal cancer. However, its exact role in tumorigenesis is unclear. In this study, we show that tumor-intrinsic c-Myb expression in mouse models of colon cancer and melanoma suppresses tumor growth. Although no differences in proliferation, apoptosis, and angiogenesis of tumors were evident in tumors with distinct levels of c-Myb expression, we observed changes in intratumoral immune cell infiltrates. MC38 tumors with upregulated c-Myb expression showed increased numbers of CD103+ dendritic cells and eosinophils, but decreased tumor-associated macrophages (TAM). Concomitantly, an increase in the number of activated cytotoxic CD8+ T cells upon c-Myb upregulation was observed, which correlated with a pro-inflammatory tumor microenvironment and increased numbers of M1 polarized TAMs. Mechanistically, c-Myb upregulation in immunogenic MC38 colon cancer cells resulted in enhanced expression of immunomodulatory genes, including those encoding β2-microglobulin and IFNβ, and decreased expression of the gene encoding the chemokine receptor CCR2. The increased numbers of activated cytotoxic CD8+ T cells contributed to tumor growth attenuation. In poorly immunogenic CT26, LLC, and B16-BL6 tumor cells, c-Myb upregulation did not affect the immunomodulatory gene expression. Despite this, c-Myb upregulation led to reduced B16-BL6 tumor growth but it did not affect tumor growth of CT26 and LLC tumors. Altogether, we postulate that c-Myb functions as a tumor suppressor in a tumor cell–type specific manner and modulates antitumor immunity.
Supplementary Figure 8 from Combined Targeting of NAD Biosynthesis and the NAD-dependent Transcription Factor C-terminal Binding Protein as a Promising Novel Therapy for Pancreatic Cancer
Authors: Dcona M. Michael , Chougoni Kranthi Kumar , Dcona Diana T. , West Jacqueline L. , Singh Sahib J. , Ellis Keith C. , Grossman Steven R.
Published: October 2023

Panc-1 cells were treated with Vehicle (Veh) or 10 nM GMX1778 for 24 h followed by addition of Vehicle or 250 µM of 4-Cl-HIPP for 48 h.
Supplementary Figure 6 from Combined Targeting of NAD Biosynthesis and the NAD-dependent Transcription Factor C-terminal Binding Protein as a Promising Novel Therapy for Pancreatic Cancer
Authors: Dcona M. Michael , Chougoni Kranthi Kumar , Dcona Diana T. , West Jacqueline L. , Singh Sahib J. , Ellis Keith C. , Grossman Steven R.
Published: October 2023

A592 of solubilized crystal violet from colony-forming assays of hTERT-HPNE, Panc-1, AsPC1, and BxPC3 cells treated with Vehicle or GMX1778 (3 nM) for 24 h followed by Vehicle (0) or 4-Cl-HIPP (250 µM) treatment for 5 days (Panc-1) or 7 days (hTERT-HPNE, BxPC3, AsPC1).
Supplementary Figure 4 from Combined Targeting of NAD Biosynthesis and the NAD-dependent Transcription Factor C-terminal Binding Protein as a Promising Novel Therapy for Pancreatic Cancer
Authors: Dcona M. Michael , Chougoni Kranthi Kumar , Dcona Diana T. , West Jacqueline L. , Singh Sahib J. , Ellis Keith C. , Grossman Steven R.
Published: October 2023

Viability of A) PaTu8988T or B) Suit2 cell lines expressing shGFP, shCtBP1, or shCtBP2, treated with Vehicle (Veh)or increasing concentrations of GMX1778 for 72 h as measured by MTT assay.
FIGURE 5 from Combined Targeting of NAD Biosynthesis and the NAD-dependent Transcription Factor C-terminal Binding Protein as a Promising Novel Therapy for Pancreatic Cancer
Authors: Dcona M. Michael , Chougoni Kranthi Kumar , Dcona Diana T. , West Jacqueline L. , Singh Sahib J. , Ellis Keith C. , Grossman Steven R.
Published: October 2023

Combined NAMPT/CtBP inhibition abrogates growth of PDAC xenografts in vivo. A, Four cohorts of 5 NSG mice each were subcutaneously xenografted with 1 × 106 Panc-1 cells and after 2 weeks of tumor growth, mice were treated three times per week for 4 weeks (see inset) by intraperitoneal injection of: (i) Vehicle (100 mmol/L NaHCO3); (ii) 4-Cl-HIPP (100 mg/kg); (iii) GMX1778 (30 mg/kg); or (iv) the combination of 4-Cl-HIPP and GMX1778. B, Tumor volume (mm3) was measured weekly using calipers and P values were calculated using multiple unpaired Student t test. Error bars indicate ±1 SD. ****, P < 0.0001 for comparison with vehicle-only treatment. C, Mean tumor weights determined at necropsy at the end of experiment on day 28 and P values were calculated using multiple unpaired Student t test. Error bars indicate ±1 SD. *, P < 0.05 for comparison with vehicle-only treatment.
FIGURE 2 from Combined Targeting of NAD Biosynthesis and the NAD-dependent Transcription Factor C-terminal Binding Protein as a Promising Novel Therapy for Pancreatic Cancer
Authors: Dcona M. Michael , Chougoni Kranthi Kumar , Dcona Diana T. , West Jacqueline L. , Singh Sahib J. , Ellis Keith C. , Grossman Steven R.
Published: October 2023

Genetic depletion or pharmacologic inhibition of CtBP sensitizes PDAC cells to GMX1778 growth inhibition. A, GMX1778 EC50 values for PaTu8988T or SUIT2 cells expressing shGFP, shCtBP1, or shCtBP2 as measured by 72 hours MTT assay. B, qPCR analysis of TIAM1 (CtBP target gene) mRNA expression after treatment of PaTu8988T cells expressing shGFP or shCtBP1 with Vehicle (0) or indicated concentrations of GMX1778 for 24 hours. The calculation was performed using the ΔΔCt approach. P values were determined by Student t test for comparison with vehicle-treated shGFP cells. C, Representative colony formation assay of PaTu8988T cells treated with Vehicle (top row) or 2 nmol/L GMX1778 (bottom row) for 24 hours, followed by treatment with Vehicle (plate 5) or indicated concentrations of 4-Cl-HIPP (plates 6–8) for 7 days, followed by crystal violet staining. D, Colony formation assay in C was quantified by measuring A592 of solubilized crystal violet. P values were determined by Student t test for comparison with vehicle-only treated cells. E, Calculation of GI50 values for 4-Cl-HIPP treatment of PaTu8988T cells with or without 2 nmol/L GMX1778 derived from colony formation assay in C. #indicates the EC50 or GI50 could not be calculated and beyond the upper range of the titration of GMX1778 or 4-Cl-HIPP, respectively. Error bars indicate ± 1 SD. N = 3 independent experiments. *, P < 0.05; **, P < 0.01; ***, P < 0.005.
Path analysis of adolescents’ reproductive health education on college students’ sexual behavior
Authors: Arifah Izzatul , Werdani Kusuma Estu
Published: October 2023

Young people are vulnerable to reproductive health (RH) problems due to their engagement in risky sexual behavior. Study of adolescents’ RH education effects on the behavior of the young will add evidence about aspects that directly/indirectly affect the behavior. This study intended to explore the influence of adolescents’ RH education and other associated factors on college students’ sexual behavior using path analysis. A cross-sectional study was conducted from March to Mei 2021 in Solo Raya Residency, Central Java, Indonesia. A sample of 20-24 years old college students from public dan two private universities (n=375) participated. An online questionnaire was used to collect the data. Path analysis was conducted to identify relationships between variables. Path analysis demonstrated that sexual behavior was directly affected by age and pornography access, regardless the gender. Even though factors that influenced sexual behavior differed among female and male students, RH education was proved to indirectly influence sexual behavior irrespective the gender. Overall, sexual behavior was influenced by RH education in the complex mechanism. Improving the information delivery of RH education is needed to ensure all youth, irrespective of gender, benefit from this program. Further study in a more significant setting in Indonesia is required.
COVID-19 pandemic and mental health of educators in higher education institution: a systematic literature review
Authors: Abdul Rahman Rahayu , Mohd Isa Noor Saatila , Zamri Norhayati , Pitalok Endang , Suyoto Yohanes Totok , Yunus Mohd Hadli Shah Mohamad
Published: October 2023

Emergency transformation of the education system due to the COVID-19 increased mental and emotional disorders risks of educators in higher education institutions. Thus, this study aims to examine how COVID-19 impacts the mental well-being of educators, and also explore the contributing factors to these issues. A systematic review was conducted, involving the identification of scientific articles related to mental health, lecturers, professors, and COVID-19. The research was performed on two reputable publication databases, SCOPUS and Web of Science. Following pre-established inclusion and exclusion criteria, this study utilized PRISMA to select and analyze the research articles. Through this process, a total of 59 articles have been identified from the electronic databases, out of which seven articles were selected for evaluation. The findings indicate that a significant number of educators encountered various mental health challenges in the midst of the pandemic, including burnout, anxiety, depression, and stress. Numerous factors, such as an imbalance between job demand and job resources, a lack of support, personal factors, and other emergency remote teaching-related factors, all contribute to the issues. This study offers valuable insights that can be utilized to develop optimal practices for educators to address and manage their mental health and well-being in the future.
Improving utilization of rotavirus vaccination among children in Kuwait: an intervention study
Authors: Khairey Walla Ahmad , Labib Nargis Albert , Alenzi Ali Noufal Yaloos Alkhalaf , Abdullah Fahad Hamed Medhi , Abdelmoaty Alshaimaa Mohamed
Published: October 2023

Vaccination against rotavirus is an effective strategy to overcome the consequences of rotavirus infection. This study aims to raise the knowledge, attitude, and practice (KAP) of both parents or caregivers and healthcare providers towards the rotavirus vaccination. The design of the study was an interventional pre-test and post-test. The type of intervention used in this study is an educational intervention. The intervention consisted of a health education message delivered to the participants including both parents or caregivers and healthcare providers. It included three phases, the first one was carried out to assess the KAP of mothers and caregivers before the intervention, the second phase involved the evaluation of participants’ post-intervention, and the third phase involved the assessment of healthcare providers. The study used a survey to assess the demographics, KAP of the participants. The collected data was analyzed using the SPSS program. The overall KAP among mothers were high (11.6%). After the intervention, the level of KAP of mothers toward the rotavirus vaccine was improved significantly (p=0.0001). Also, after the health education message, the level of KAP of the healthcare providers was significantly improved (p=0.0001). The levels of KAP of mothers and healthcare providers were improved after the educational intervention and the health educational message, reflecting the important role of educational intervention in raising the awareness of both mothers and healthcare providers.
Is a good relationship enough for a good life?
Authors: Xu Efendy , Prihadi Kususanto Ditto , Wulandari Primatia Yogi , Adiati Rosatyani Puspita , Cahyono Rudi , Widayat Iwan Wahyu , Indrijati Herdina , Septarini Berlian Gressy , Nisa Valina Khiarin
Published: October 2023

Satisfaction with life is an important element of mental health as its protective features against depression, anxiety, and other mental health problems. The bottom-up theory of life satisfaction explained that satisfaction in specific domains tend to sum up to general life satisfaction. accordingly, studies reported that relationship satisfaction predicts general life satisfaction This cross-sectional study aims to investigate the role of two variables, namely perceived social support (PSS) and mattering. We hypothesized that PSS and mattering perform full serial mediation on the link relationship between relationship satisfaction and life satisfaction. 256 individuals who live in several urban areas in West Malaysia were recruited through purposive sampling to respond to online form consisted of scales of relationship satisfaction, satisfaction with life, general mattering scale and multidimensional scale of perceived social support. Bootstrap method with 95% confidence interval and 5,000 samples was conducted through PROCESS Macro model 6; the results suggested that a significant, full serial mediation occurred. Additionally, both PSS and mattering significantly predicted life satisfaction after controlling for each other.
Promoting positive youth development and well-being: lesson learned from youth integrated health post in Indonesia
Authors: Yudanagara Bani Bacan Hacantya , Surjaningrum Endang Retno , Syamsir Syamikar Baridwan
Published: October 2023

Indonesia is a multicultural country with many indigenous people, including the Tengger tribe, who live in the mountainous area called Tosari. Limited access in rural areas and various risky behavior are the challenges for youth to develop optimally. To fill this gap, Tosari youth, together with midwives and the village office, initiated a youth-integrated health post called posyandu youth (PR), which was adapted to local culture. This study determined outcomes, program quality, and the possibility of PR program development using the positive youth development (PYD) framework. This study employed a qualitative design with a case study approach. From semi-structured interviews with various key stakeholders of PR, findings reveal a connection between the PR program quality and the positive health and well-being outcomes among participants. Based on these findings, several recommendations for maximizing PR as a youth development program to improve PYD and well-being among indigenous youth are provided.
Why they willingly become victims of dating violence: a phenomenological study based on female adolescent perspective
Authors: Ayu Suci Musvita , Shaluhiyah Zahroh , Widjanarko Bagoes , Purwanti Ani
Published: October 2023

Dating has become a trend in today's youth. Psychological conditions are still unstable and are one of the triggers for violence among adolescents, and in general, female adolescents become victims. However, the female adolescents maintained the relationship. Therefore, this study aimed to conduct a phenomenological study of dating violence among female adolescents. This research is included in the type of qualitative research. Data were obtained from five key informants and five triangular informants who were selected using a purposive sampling technique. Data was collected using 14 questions items submitted using the In-depth Interview technique. The interview results were transcribed using computer aided qualitative data analysis software. Based on the results of the interviews, dating is a form of self-actualization to get love and to exist among adolescents. They hope the current partner can become a life partner when they have a family. This is their reason for tolerating physical, psychological, or sexual violence perpetrated by their partner. So, female adolescents are aware that they experience violence. However, they could not avoid it because they hoped their current partner would become a life partner These results confirm the urgency for adolesence dating violence (ADV) program implementation.
Factors related to HbA1c in the first trimester of pregnancy
Authors: Sumarah Sumarah , Anies Anies , Rahfiludin Mohammad Zen , Sulistiyani Sulistiyani
Published: October 2023

The prevalence of gestational diabetes mellitus (GDM) in the world is 16.2% of live births associated with hyperglycemia in pregnancy, and 7.4% are caused by type 1 or 2 diabetes which is detected for the first-time during pregnancy. The prevalence of GDM in Indonesia reaches 3.6% and the highest rate is found in the Special Province of Yogyakarta (2.6%). One of the risk factors for GDM is excess nutrition which is influenced by daily intake. This study aims to determine the relationship between nutritional intake and body mass index (BMI) with HbA1c levels in first-trimester pregnant women. This study used a cross-sectional design. A simple random sampling with inclusion and exclusion criteria was employed, involving 47 pregnant women as subjects. Nutritional intake was measured with the semi-quantitative food frequency questionnaire (SQ-FFQ). The nutritional status of pregnant women is measured by BMI. HbA1c was measured by the turbidimetric inhibition immunoassay (TINIA) method. Analysis of research data using the Pearson product-moment correlation test and rank Spearman. The results of this study stated that there was a relationship between nutritional intake and BMI with HbA1c levels. Diagnosis of GDM and appropriate intervention can reduce the risk of complications of diabetes mellitus (DM).
Validation of smartphone addiction scale-short version among Malaysian undergraduate students
Authors: Wong Boon Yew , Yeo Kee Jiar , Lee Shih-Hui , Handayani Lina
Published: October 2023

Smartphone addiction scale-short version or SAS-SV has been consistently found to have one-factor structure and proven as a valid and reliable instrument to measure smartphone addiction. However, it has not been validated among the undergraduate students in Malaysia. With the aim to address such empirical gap, this study has validated its one-factor structure and assessed its reliability and validity among the 680 undergraduate students in Universiti Teknologi Malaysia (UTM). Its content validity was first demonstrated. Subsequently, the findings of confirmatory factor analysis (CFA) have supported and confirmed its one-factor model. Furthermore, its convergent validity and reliability were also proven to be satisfactory. Taken together, this study has demonstrated that SAS-SV is an instrument that can reliably and accurately measure or identify smartphone addiction symptoms among the undergraduate students in Malaysia.
Correlates of Presence in a Virtual Reality Gamification Environment for Rehabilitation after Musculoskeletal Injury
Authors: Gouveia Élvio Rúbio , Nascimento Marcelo de Maio , França Cíntia , Campos Pedro , Ihle Andreas , Przednowek Krzysztof , Marques Adilson , Nunes Nuno , Gouveia Bruna R.
Published: October 2023

Virtual reality (VR) has emerged as a powerful option for rehabilitation by providing real-time performance feedback and a safe and customized training environment. This study aimed: (1) to investigate the association between presence in the virtual environment, usability of the system, intrinsic motivation, and immersion in VR gaming designed for rehabilitation after musculoskeletal injury; and (2) to examine the users’ emotional response in terms of pleasure, arousal, and dominance after participating in VR gaming. Thirty-seven individuals aged 23.69 ± 6.98 years participated in five customized VR games designed to provide a complete rehabilitation session after a musculoskeletal injury. Pearson product-moment correlation coefficients and multiple regression analyses were used to investigate the relationship between presence in virtual environments and immersive tendencies, the usability of the system, and intrinsic motivation. The Wilcoxon Signed Rank Test was conducted to evaluate the impact of participation in VR gaming on participants’ presence in virtual environments. Significant correlations were found between presence and immersive tendencies (r = −.40, p = .017), intrinsic motivation (r = .42, p = .013), and usability of the system (r = .64, p < .001). The linear regression model explained 59% of the total variance in the presence of virtual environments. There was a statistically significant increase in the pleasure scores from the beginning to the end of the session. Our results indicate that VR may be useful in increasing adherence to treatment to recover from musculoskeletal injuries.
Brazilian fauna of Cerambycidae (Coleoptera): description of a new species and new records
Authors: MONNÉ MIGUEL A. , SANTOS-SILVA ANTONIO , FLECHTMANN CARLOS ALBERTO HECTOR , OLIVIER RENAN DA SILVA
Published: October 2023

The publication date of one of the works by Louis Alexandre Auguste Chevrolat is corrected. New records are provided for the following species and, in some cases, also with taxonomical notes: Cosmoplatidius lycoides (Guérin-Méneville, 1844); Eburodacrys notula Gounelle, 1909; Paranyssicus conspicillatus (Erichson, 1847); Argyrodines aurivillii (Gounelle, 1905); Hemilissa cornuta Bates, 1870; Isthmiade ichneumoniformis Bates, 1870; Chevrolatella tripunctata (Chevrolat, 1863); Oxymerus basalis (Dalman, 1823); Tropidion flechtmanni Santos-Silva, Nascimento & Biffi, 2019; Atrypanius remissus (Erichson, 1847); Nyssodrysternum amparense (Melzer, 1934); Nyssodrysternum rubiginosum Monné, 1975; Aegoschema moniliferum (White, 1855); Hippopsis quinquelineata Aurivillius, 1920; Callia fulvocincta Bates, 1866; Drycothaea angustifrons (Breuning, 1943); Drycothaea anteochracea (Breuning, 1974); Allocarterica buquetii (Thomson, 1860); Aerenea sulcicollis sulcicollis Melzer, 1932; Desmiphora (Desmiphora) lenkoi (Lane, 1959); Cacostola zanoa Dillon & Dillon, 1946; Sternycha diasi Martins & Galileo, 1990; and Anobrium punctatum Galileo & Martins, 2002. Correction of the Brazilian state of the type locality or previous records of the following species is provided: Chrysoprasis hypocrita Erichson, 1847; Coccoderus longespinicornis Fuchs, 1964; Compsibidion fairmairei (Thomson, 1865); Cycnidolon obliquum Martins, 1969; Dioridium hirsutum Zajciw, 1961; Eburodacrys rubicunda Monné & Martins, 1992; Engyum aurantium Martins, 1970; Oxymerus basalis (Dalman, 1823); Pachypeza phegea Dillon & Dillon, 1945; Aerenea brunnea Thomson, 1868. A forgotten record of Poeciloxestia minuta Fragoso, 1978 is pointed out. Trachyderes variegatus Perty, 1832 is considered a junior synonym of Andraegoidus nigrofasciatus (Gory, 1831). A new species of Acanthocinini (Lamiinae), Lophopoeum paiolai sp. nov., is described from Brazil and French Guiana.
Morphological and Molecular Characterization of Two New and Two Already Known Species of the Genus Pallisentis (Acanthocephala: Quadrigyridae) from India with an Update in Key to the Species
Authors: RANA KHUSHBOO , KAUR HARPREET
Published: October 2023

To date, 31 species assigned to the genus Pallisentis Van cleave, 1928 have been reported from India. The present study includes morphological and molecular descriptions of two new species of Pallisentis Van Cleave, 1928, namely P. himachalensis and P. longus from the fresh water fishes Channa punctata (Bloch, 1793) and C. marulius (Hamilton, 1822), respectively, procured from Himachal Pradesh and Chandigarh, India. Of total 35 fishes, 17 were found infected with acanthocephalan parasites. The prevalence of infection was 42.85 and 52.38% for C. punctata and C. marulius, respectively. The morphological characters of P. himachalensis n. sp. include proboscis with 4 circles of hooks with 8–10 hooks per circle, which gradually decline in size. The trunk in male comprises 15–16 circles of collar spines and 27–37 circles of trunk spines ending above the anterior testis with syncytial cement gland having 26–29 nuclei. The trunk in female comprises of 14–18 circles of collar spines and 55–73 circles of trunk spines present till the anterior end of reproductive system with additional 3–4 circles at the posterior end. P. longus n. sp. is the longest species reported in the genus and the length of female reach up to 44 mm. The proboscis comprises 4 circles of proboscis hooks with 9–10 hooks per circle. In males 13–16 circles of the collar spines and 27–31 circles of trunk spines are present with syncytial cement gland containing 20–25 nuclei. The females are much longer with 15–16 circles of collar spines and 64–69 circles of trunk spines present till the posterior end. The study also reports two already described species: P. gomtii Gupta and Verma, 1980 from C. punctata and P. nandai Sarkar, 1953 from C. marulius. Total 12 sequences for 4 species have been generated based on 18S, 28S and ITS1–5.8S–ITS2 molecular markers. The 18S and ITS1–5.8S–ITS2 Bayesian inference trees generated in the present study showed distinct identities of all 4 species. Moreover, the Bayesian inference tree generated in the present study based on 18S showed the clustering of Pallisentis species in three different clades compared to the previous studies in which only two clades within the genus were reported. The molecular analysis showed the monophyletic origin of the genus Pallisentis and does not support subgeneric classification within the genus.
What are the precise reasons for the disparity in referrals to fitness to practise between international and UK medical graduates?
Authors: Adhiyaman Vedamurthy , Hobson Peter , Sundaram Radha , Williams Llinos
Published: October 2023

Purpose of the study

To discover the precise reasons for referring a doctor to the Medical Practitioners Tribunal Service, and whether there are any disparities between referrals of international medical graduates and UK graduates. Further to consider whether understanding the precise reasons would provide insight into the nature of referrals.

Study design

We collected and analysed the data from the Medical Practitioners Tribunal Service website over a period of 12 months.

Results

There were 228 cases of which 142 (62%) were international medical graduates and 86 (38%) were UK graduates. More international medical graduates were referred for professional misconduct, poor performance and lack of adequate English language. The common reasons for professional misconduct were providing sub-optimal care, sexual misconduct and dishonest behaviour. More UK graduates were referred following convictions due to offences related to alcohol intake and financial dishonesty. There is paucity of good quality information to identify the exact reasons for the disparity.

Conclusion

More international medical graduates were referred to the Medical Practitioners Tribunal Service than UK graduates. There was disparity in the nature of the referrals and we hope our findings will inform employers and the regulatory bodies to understand that comprehensive induction, inclusion, mentoring and adjustments are needed to support international medical graduates to mitigate the risks of failure and help them to meet the required professional standards.
Medico-legal scene investigation in the case of burned bodies – a systematic review
Authors: D’Antonio Gianpiero , Serinelli Serenella , Albore Marco , Bolino Giorgio
Published: October 2023

A judicial on-site examination is essential for the correct analysis of a forensic case, particularly when there has been a fatal fire, as heat-related changes to bodies make identification by the forensic pathologist and other specialists difficult along with estimating the post-mortem interval and determining the precise cause and manner of death. We systematically reviewed all relevant articles dating from 2003 to 2022 in the PubMed database with a view to updating recommendations on how best to proceed. Our recommendations highlight the importance of a multidisciplinary team approach involving various forensic specialists.
A fuzzy mathematical model for hybrid inventory and purchase optimization in a reverse logistics system considering shortage and warehouse capacity
Authors: Tang Hongyu , Thelkar Amruth Ramesh
Published: October 2023

Making decisions about the design and implementation of a logistics network is crucial as it has long-term impacts. However, it is important to consider that demand factors and the number of returned items by customers may change over time. Therefore, it is necessary to design a logistics network that can adapt to various demand fluctuations. The main goal of this study is to calculate the quantity of products that should be sent at different times in a supply chain network to minimize the overall cost of reverse logistics and tardiness time. Accordingly, a multi-objective mathematical model is proposed that aims to optimize the total cost and the amount of delay in sending customer orders in a three-level logistics network, assuming that some parameters are uncertain. Additionally, the minimization of waiting time, considering the level of delay in sending, is applied as the second objective function. To handle the uncertainty in the reverse logistics network, a fuzzy approach is implemented, and the proposed model is solved using GAMS software. Furthermore, to solve the mathematical model in large dimensions, the Cuckoo Optimization Algorithm (COA) is applied in MATLAB software, and the results are compared to the global optimal solution. The outcomes show that the proposed algorithm has a desirable performance, as the total values sent to the manufacturer are equal to those obtained from the exact solution, and the objective function value decreases as the number of repetitions increases.
The Long Shadow of a Major Disaster: Modeled Dynamic Impacts of the Hypothetical HayWired Earthquake on California’s Economy
Authors: Sue Wing Ian , Rose Adam , Wei Dan , Wein Anne
Published: October 2023

We develop and apply a dynamic economic simulation model to analyze the multi-regional impacts of, and mechanisms of recovery from, a major disaster, the HayWired scenario — a hypothetical Magnitude 7.0 earthquake affecting California’s San Francisco Bay Area. The model integrates loss pathways: capital stock damage, labor supply shocks due to short-term population displacement and longer-run out-migration from damaged areas, and the exacerbating effects of damage to transportation infrastructure capital, as well as various aspects of static and dynamic economic resilience. With input substitution-based static inherent resilience and dynamic resilience in the form of optimal intertemporal and spatial investment allocation, gross output losses range from 0.5 percent to 6 percent across regions, and welfare losses are 0.4 percent statewide but can be ten times as large in hardest-hit areas. Large-scale reconstruction investment is supported by substantial interregional transfers of resources through intra-state trade. Increased output via firms engaging in the key adaptive resilience tactic of production recapture can alleviate a substantial fraction of losses—but only if upstream and downstream barriers to recovery can be lowered quickly.
The Effects of Intergenerational Ministry on the Transmission of Christian Faith in Korean Immigrant Churches in the United States
Authors: Lee Hyun Ae
Published: October 2023

Given the challenges of young people leaving the Christian faith, this research sought to explore the effects of intergenerational ministry on the transmission of the Christian faith to the next generation of Korean immigrant churches in the United States. A total of 35 participants (primary sample: 17 young adults; subsamples: nine parents and nine pastors) participated in semi-structured in-depth interviews. Results from this study generated nine themes revealing factors and effects of intergenerational ministry.
Synchronous fault-tolerant consensus control and disturbance rejection for leader-following multi-agent systems with fault of polynomial form
Authors: Xiao Xiong , Pang Guochen , Mou Xiaojian , Zhang Ancai , Qiu Jianlong , Cao Jinde
Published: October 2023

This article studies the design problem of fault-tolerant and disturbance rejection control for leader-following multi-agent systems with polynomial form fault. First, a novel observer is designed to estimate polynomial form faults and external disturbances in the tracker. Second, a fault-tolerant control protocol is designed for each follower based on the obtained estimates; the designed distributed controller can effectively achieve both the goal of fault-tolerant control and the effect of disturbance rejection. Finally, a simulation result of a practical example is presented to verify the feasibility of the proposed scheme.