bluuebunny/crossref_metadata_2025 huggingface dataset:
Trailing TRAIL Resistance in Human Breast Adenocarcinoma Cells with Trichostatin
A and Zebularine
Authors: Ngai Siew Ching , Wong Sonia How Ming , Fang Chee-Mun , Loh Hwei-San
Published: November 2022

Aims:

The aim of this study was to sensitize the resistant breast adenocarcinoma cells towards Tumour Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)-induced apoptosis.

Background:

Breast cancer is a heterogeneous disease involving complex mechanisms. TRAIL is a potential anti-cancer candidate for targeted treatment due to its selective killing effects on neoplastic cells. Nonetheless, resistance occurs in many cancers either intrinsically or after multiple treatments.

objective:

Therefore, this research investigated whether the combination of Trichostatin A (TSA) and Zebularine (Zeb) (TZ) followed by TRAIL (TZT) could sensitize the human breast adenocarcinoma cells towards apoptosis.

Objective:

Therefore, this research investigated whether the combination of Trichostatin A (TSA) and Zebularine (Zeb) (TZ) followed by TRAIL (TZT) could sensitize the human breast adenocarcinoma cells towards apoptosis.

Methods:

The breast adenocarcinoma cells, MDA-MB-231, MCF-7 and E-MDA-MB-231 (E-cadherin re-expressed MDA-MB-231) were treated with TSA, Zeb, TZ, TRAIL and TZT. The cells were subjected to hematoxylin and eosin (H & E) staining and FITC-Annexin V/Propidium Iodide apoptosis detection prior to proteome profiling.

Results:

Based on morphological observation, apoptosis was induced in all cells treated with all treatment regimens though it was more evident for the TZT-treated cells. In the apoptosis detection analysis, TZ increased early apoptosis significantly in MDA-MB-231 and MCF-7 while TRAIL induced late apoptosis significantly in E-MDA-MB-231. Based on the proteome profiling on MDA-MB-231, TRAIL R2 and Fas expression was increased. For E-MDA-MB-231, down-regulation of catalase, paraoxonase-2 (PON2), clusterin, an inhibitor of apoptosis proteins (IAPs) and cell stress proteins validated the notion that E-cadherin re-expression enhances TZT anti-cancer efficacy. Similar trend was observed in MCF-7 whereby TZT treatment down-regulated the anti-apoptotic catalase and PON2, increased the pro-apoptotic, B cell lymphoma 2 (Bcl-2)-associated agonist of cell death (Bad) and Bcl-2-associated X (Bax), second mitochondria-derived activator of caspase (SMAC) and HtrA serine peptidase 2 (HTRA2) as well as TRAIL receptors (TRAIL R1 and TRAIL R2).

Conclusion:

TZ treatment serves as an efficient treatment regimen for MDA-MB-231 and MCF-7, while TRAIL serves as a better treatment option for E-MDA-MB-231.

other:

Therefore, future studies on E-cadherin’s positive regulatory role in TRAIL-induced apoptosis are definitely warranted.

Other:

Therefore, future studies on E-cadherin’s positive regulatory role in TRAIL-induced apoptosis are warranted.
Older Adults with Type 2 Diabetes Treated with Metformin: AME-MET
Study - A Multicentric Real-world Study in Italy
Authors: Elena Castellano , Borretta Giorgio , Attanasio Roberto , Alberto Boriano , Agrimi Daniela , Argese Nicola , Crescenti Cassandra , Disoteo Olga , Fusco Alessandra , Gabellieri Enrico , Guglielmi Rinaldo , Lisco Giuseppe , Lo Pomo Feliciano , Nizzoli Maurizio , Panico Annalisa , Pirali Barbara , Salcuni Antonio Stefano , Turchi Federica , Grimaldi Franco
Published: November 2022

Aims:

Metformin is the most widely used drug for the first-line treatment of type 2 diabetes mellitus (T2DM), but its use and schedule have been poorly investigated in elderly patients.

Methods:

We conducted an observational, cross-sectional, multicentric study on metformin in T2DM outpatients older than 65 years who were taking the drug for at least 6 months and referred to Italian Endocrinology and Diabetology Services. The primary endpoint was daily metformin dose, and secondary endpoints were the correlations between metformin dose and age, comorbidities, and concomitant use of other drugs. The study was open to all members of AME (Associazione Medici Endocrinologi).

Results:

Fifteen Italian centers recruited 751 consecutive participants (42.9% older than 75 years,
48.6% females). T2DM duration was 12.9 ± 9.7 years (longer than 10 years in 53.8%). Metformin had
been used for 10.3 ± 6.8 years (longer than 10 years in 52.4%). Metformin dose was 1.6 ± 0.9 g/day
(>1.5 g/day in 63.4%). As compared to the youngest, participants older than 75 years did not differ for
metformin daily dose or number of administrations. Metformin dose was significantly directly correlated
to eGFR, diabetes duration, and metformin treatment duration.

Conclusion:

In this real-world study, the minimum daily effective dose of metformin was prescribed in more than half of older T2DM outpatients.
Investigating Physical Properties and Formation Mechanism of Biosynthesized
Zinc Oxide Nanoparticles using Dill (Anethum graveolens) Leaf
Extract
Authors: Barzinjy Azeez Abdulla , Hamadamen Venus Nazim
Published: November 2022

Background:

Nanotechnology is a novel and developing arena of science. The building block
of nanotechnology is nanoparticles (NPs); their size is less than 100 nm. The NPs are synthesized using
two dissimilar approaches, namely top-down and bottom-up approaches. The leading methods for producing
NPs are chemical and physical methods and are frequently expensive and hypothetically dangerous to
both the surroundings and the user.

Objective:

Consequently, the researchers intended to synthesize NPs using biological ingredients such as
plant extracts, bacteria, fungi, algae and yeasts. Nevertheless, the available phytochemicals in plant extracts,
compared with other microorganisms, own an extremely extraordinary capacity for metal ions reduction
within a short period, which requires a lengthier cultivation time.

Methods:

In this study zinc oxide (ZnO) NPs have been produced utilizing Dill (anethum graveolens) leaf
extract. This process is an easy, one-pot, inexpensive and green process, i.e. isolated from utilizing toxic
materials.

Results:

Various characterization techniques have been utilized to inspect the structure, size, morphology,
chemical composition and optical properties of the ZnO NPs. Additionally, the mechanism of formation
of ZnO NPs from Dill (anethum graveolens) leaf extract has been explained intensively.

Conclusion:

This investigation revealed that Dill (anethum graveolens) leaf extract is a suitable environment
for producing nanosize ~27 nm, spherical, monodisperse, wide band gap ~ 3.56 eV, highly crystalline
and 1:1 Zn to O ratio ZnO NPs.
SENSORY PROFILE OF CHILLED CHEESECAKE MADE FROM DALI NI HORBO CHEESE IN CONSUMER PERCEPTION
Authors:   Sekolah Tinggi Pariwisata Bandung, Luthfi Tristy Firlyanie , Josary P Jessica J. ,   Sekolah Tinggi Pariwisata Bandung, Novianti Selvi ,   Sekolah Tinggi Pariwisata Bandung, Sanggramasari Sandra ,   Sekolah Tinggi Pariwisata Bandung, Yuniastuti Made Citra ,   Sekolah Tinggi Pariwisata Bandung
Published: November 2022

This research is a contribution to the use of dali ni horbo in the making of cheesecake and all the variations, so that consumer-based sensory profile characterization can be carried out. The purpose of this study was to determine the characteristics of the sensory profile and accelerate the cheesecake product development process. The method used in this study is an experiment that uses a consumer-based sensory profile characterization method. Later, it was known that the ideal dali cheesecake product according to panelists is cheesecake which has creamy color, dense texture, cheesy aroma and umami flavor. Dali cheesecake variant which was added with durian is a product that is considered close to the ideal product. Meanwhile, the sensory attributes of umami, dense and sweet are sensory attributes that were close to consumer preferences, but it was possible to do dali cheesecake development with other flavor variants.
KARAKTERISTIK FISIK EDIBLE FILM BERBAHAN DASAR PATI BATANG KELAPA SAWIT TERMODIFIKASI DAN TAPIOKA
Authors:   Institut Teknologi Perkebunan Pelalawan Indonesia, Mutia Reiza , Prendika Wimpy ,   Institut Teknologi Perkebunan Pelalawan Indonesia, Yunita Imelda ,   Institut Teknologi Perkebunan Pelalawan Indonesia, Andriani Yuli ,   Institut Teknologi Perkebunan Pelalawan Indonesia
Published: November 2022

Pati batang kelapa sawit yang telah dimodifikasi berpotensi dijadikan edible film. Tapioka ditambahkan sebagai campuran untuk meningkatkan sifat fisik edible film. Tujuan penelitian yaitu mengetahui karakteristik fisik edible film berbahan baku pati batang kelapa sawit termodifikasi dan tapioka serta menentukan rasio terbaik untuk menghasilkan edible film. Rancangan Acak Lengkap (RAL) Non Faktorial digunakan sebagai desain penelitian dengan perlakuan rasio bobot pati batang kelapa sawit termodifikasi dan tapioka. Rasio bobot yang digunakan adalah 1:3, 1:1, 3:1 (b/b). Parameter yang diamati adalah ketebalan, pemanjangan saat putus dan kekuatan tarik edible film. Hasil uji ANOVA pada taraf 5% didapatkan bahwa rasio bobot pati batang kelapa sawit termodifikasi dan tapioka berpengaruh nyata terhadap parameter kekuatan tarik, tetapi tidak berpengaruh terhadap parameter ketebalan dan pemanjangan saat putus edible film. Perlakuan 1:3 (b/b) merupakan perlakuan terbaik untuk menghasilkan edible film dengan karakteristik fisik antara lain ketebalan 0.15 mm, pemanjangan saat putus 23.00%, dan kekuatan tarik 6.07 MPa.
DEVELOPMENT OF TIME-TEMPERATURE INDICATOR FROM RED PALM OIL AND MAIZE OIL BLENDING
Authors:   Institut Pertanian Stiper Yogyakarta, Widyasaputra Reza , Ruswanto Adi ,   Institut Pertanian Stiper Yogyakarta, Ngatirah Ngatirah ,   Institut Pertanian Stiper Yogyakarta, Sunardi Sunardi ,   Institut Pertanian Stiper Yogyakarta
Published: November 2022

Time-temperature indicator could be used to monitor temperature changes during storage and distribution. The time-temperature indicator with red palm oil and maize oil was evaluated to find the diffusion prediction model and the right oil blending proportion based on activation energy. This research was performed in two stages. Stage 1 was production of red palm oil and maize oil blending in five ratios: A1 (70:30), A2 (60:40), A3 (50:50), A4 (40:60), A5 (30:70) (%v/v). Stage 2 was measurement of diffusion rate, coefficient, kinetics and activation energy in photo paper medium at 4, 29, 37, 44 and 51 °C. The result showed that increasing the temperature could increase diffusion rate and coefficient. The A5 blending proportion had 36.7961 kJ/mol energy activation which were in range of commercial time-temperature indicator (34-50 kJ/mol). The diffusion prediction model was Ln D = -4425.8 – 3.1187.
PREFERENSI WANITA USIA SUBUR TERHADAP MADU LEBAH TANPA SENGAT SEBAGAI KANDIDAT PRODUK ANTIEMESIS
Authors:   Universitas Padjadjaran, Ikhsan Fajar Abhirama Akhsanul , Nurhadi Bambang ,   Universitas Padjadjaran, Mahani Mahani ,   Universitas Padjadjaran
Published: November 2022

Ibu hamil memiliki gangguan mual dan muntah (emesis), yang membuat nafsu makan menurun dan secara tidak langsung mengurangi asupan gizi untuk janin. Salah satu bahan pangan yang dapat betindak sebagai antiemesis adalah madu. Madu memiliki karakteristik sensori yang dipengaruhi sifat fisikokimia, hal ini dapat memengaruhi preferensi ibu hamil dalam menentukan madu yang disukai. Penelitian ini bertujuan untuk mengetahui preferensi Wanita Usia Subur (WUS) dalam memilih madu Lebah Tanpa Sengat sebagai kandidat produk antiemesis. Metode yang dilakukan adalah pengujian organoleptik dengan uji hedonik menggunakan panelis WUS sebagai model dari ibu hamil. Untuk sampel madu yang digunakan berasal dari berbagai wilayah di Indonesia seperti Sulawesi Selatan, Banten, Bogor, Kalimantan Timur, Jawa Timur, Kalimantan Barat, dan Bengkulu. WUS memiliki preferensi tertinggi pada madu lebah Tetragonula biroi yang berasal dari Bogor dengan karakteristik fisikokimia seperti kadar air sebesar 28.79 ± 0.31%, tingkat keasaman sebesar 118.76 ± 5.08 ml NaOH 1N/kg, , kadar gula pereduksi sebesar 29.22 ± 5.11%, kadar HMF sebesar 79.75 ± 1.77 mg/kg.
DEVELOPMENT OF CORN FLOUR-BASED RICE ANALOG WITH THE ADDITION OF YLANG FLOWER EXTRACT AS A FLAVOR ENHANCEMENT
Authors:   Universitas Muhammadiyah Malang, Haditama Putri Khairi , Permatasari Khairani ,   Universitas Muhammadiyah Malang, Sukma Nimas Aura ,   Universitas Muhammadiyah Malang, Rian Muhammad Alif ,   Universitas Muhammadiyah Malang
Published: November 2022

Rice is the biggest staple food source in Indonesia, and its consumption has also become a habit in Indonesia. Rice analog of corn flour and ylang flower extract can be developed to reduce this natural rice consumption. Ylang flower extract can increase the antioxidant content and add aroma to rice analog. This research aims to develop alternative food products that have better physicochemical properties and can prevent degenerative diseases. The study was conducted using a Randomized Block Design (RBD) method with one factor, which is the concentration of ylang flower extract consisting of five levels, including 0%, 35%, 40%, 45%, and 50%. The results showed that the addition of ylang flower extract affects the rehydration power, rice analog color, proximate test results, and antioxidant activity. Furthermore, the addition of ylang flower extract also affects the amylose content and organoleptic test. The best formulation of rice analog was obtained from the addition of 35% ylang flower extract.
Análisis panbiogeográfico de las especies de Heterolinus y Homalolinus (Coleoptera: Staphilinidae: Xantholini)
Authors: Márquez Juan , Morrone Juan J.
Published: November 2022

Se llevó a cabo un análisis panbiogeográfico de la distribución de las especies de Heterolinus Sharp y Homalolinus Sharp con el fin de contribuir al estudio de las relaciones biogeográficas de Mesoamérica. Las tres especies de Heterolinus se distribuyen principalmente en el  noroeste de América del Sur, solo H. basiniger Márquez se ha registrado además en Costa Rica. Las especies de Homalolinus se distribuyen en México, América Central, y solo tres se registran para América del Sur, una de ellas endémica de Ecuador. México es el país con el mayor número de especies de Homalolinus (16), seguido por Costa Rica (12), Guatemala (8) y Panamá (7). Mediante el análisis de trazos, se obtuvieron seis trazos generalizados: Eje Volcánico Transmexicano, Sierra Madre Oriental, Sierra Madre del Sur, Mesoamericano septentrional, Mesoamericano meridional y Sudamericano del noroeste. Se identificó un nodo en la confluencia de los cuatro primeros trazos generalizados en el área de la Sierra de Juárez, Oaxaca. Las barreras propuestas por Halffter (1987), como el Istmo de Tehuantepec, las tierras bajas de Nicaragua y el Istmo de Panamá, se identificaron como posibles eventos de vicarianza. La distribución de los taxones estudiados apoya la propuesta de trazos generalizados de Morrone y Márquez (2001).
Proculus, giant latin-american passalids: revision, phylogeny and biogeography
Authors: Schuster Jack C. , Cano Enio B. , Reyes Pedro
Published: November 2022

The genus and its five known species are redescribed and P. jicaquei sp. nov. is described. Synonymies include P. beckeri Zang, 1905 with P. opacipennis (Thompson, 1857) (new synonymy), P. mandibularis Casey, 1914 with P. burmeisteri Kuwert, 1891 (new synonymy), P. magister Casey, 1897 with P. mniszechi Kaup, 1868 (new synonymy), P. densipennis Casey, 1914 with P. opacipennis (Thompson, 1857) (new synonymy), and P. kraatzi Kuwert, 1898 with P. mniszechi Kaup, 1868 (new synonymy). We include a phylogenetic analysis, keys for larvae and adults, and biogeographic information for each species. The genus occurs from Mexico to Colombia. Proculus mniszechi is parapatric with P. burmeisteri and partially sympatric with P. opacipennis in Sierra de las Minas, Sierra de Santa Cruz and Cuchumatan Mountains; P. mniszechi occurs in a type of cloud forest above 1500 m altitude, whereas P. opacipennis occurs in another cloud forest type below 1500 m. Proculus opacipennis has a similar relation with P. opacus Kuwert 1891 in the Cuchumatan Mountains, where P. opacus apparently replaces P. mniszechi. Proculus goryi (Melly, 1833) occurs in the volcanic chain of the Pacific coast of Guatemala and Chiapas, Mexico. Proculus jicaquei sp. nov. is known only from the mountains northwest of Yoro, Honduras. Phylogenetic hypothesis shows that P. jicaquei is most closely to P. goryi, these two taxa form a sister clade to all other Proculus species. Proculus mniszechi and P. burmeisteri are sister taxa, as are P. opacus and P. opacipennis.
The Impacts of Offshore Wind Farms (OWFs) on Local Tourism and Recreation -- Evolving Lessons from Practice
Authors: Glasson John , Durning Bridget , Welch Kellie
Published: November 2022

The article examines the nature of impacts of the rapidly growing Offshore Wind Farm (OWF) industry on tourism and recreation in coastal communities, especially in the UK. The multi-methods research approach includes reviews of literature, content of OWF Environmental Statements (ESs) for predicted impacts, recent practice for actual impacts, and the use of mitigation and enhancement measures. Findings from literature indicate that the overall impact on tourism appears relatively benign, and sometimes positive. The UK ES review identified tourism as an important topic, identifying mostly no/negligible predicted negative impacts, and some examples of predicted positive impacts. There is limited use of enhancement measures, including visitor centres and boat trips, and a previously under-reported use of developer community benefits funding for local area recreation and tourism facilities. Recommendations include early engagement with the community, developer long-term commitment to mitigation and enhancement measures, plus monitoring of tourism and recreation impacts over time.
Emerging Nutrition Approaches to Support the Mind and Muscle for Healthy Aging
Authors: Mey Gabrielle , Mey Jacob
Published: November 2022

This narrative review highlights recent advances and ongoing trials using nutrition approaches for healthy aging. Focus will be placed on nutrition therapies that target cognition (“the mind”) and mobility (“the muscle”), both critical components to maintaining a high quality of life for older adults. For “the mind,” two seemingly incongruent therapies are being investigated to improve cognition–the MIND diet (high in carbohydrates and anti-oxidant fruits and vegetables) and the ketogenic diet (low in carbohydrates, high in fats). For “the muscle,” a focus on protein and energy intake has dominated the literature, yet a recent clinical trial supports the use of whole-grains as a tool to improve whole-body protein turnover–a primary regulator of lean body mass and muscle. Finally, emerging data and clinical trials on caloric restriction have solidified this strategy as the only nutritional approach to slow intrinsic factors of whole-body aging, which may positively impact both “the mind” and “the muscle.”
Patient and Therapist Expectations for a Blended Cognitive Behavioral Therapy Program for Depression: Qualitative Exploratory Study
Authors: Atik Ece , Schückes Magnus , Apolinário-Hagen Jennifer
Published: November 2022

Background

Blended cognitive behavioral therapy (bCBT)—the combination of digital elements and face-to-face psychotherapy—has been proposed to alleviate challenges that patients and therapists face in conventional cognitive behavioral therapy. There is growing evidence that adding digital elements to face-to-face psychotherapy can contribute to better treatment outcomes. However, bCBT programs still show considerable shortcomings, and knowledge on how to improve digital apps using a bCBT protocol is limited.

Objective

This study aimed to inductively identify functions and qualities that are expected from a bCBT treatment for depression in the eyes of patients and psychotherapists who were not currently receiving or practicing bCBT treatment.

Methods

We used a qualitative exploratory study design and conducted 3 focus group interviews (n=6 in each) and 5 semistructured in-depth interviews with therapists as well as 11 individual interviews with patients with a primary diagnosis of depression and currently undergoing cognitive behavioral therapy treatment in Germany. Themes and categories were established inductively from transcribed interview records based on a rigorous coding method.

Results

Both therapists and patients expected a digital app to provide patients with the opportunity to track their mood, work on therapeutic homework activities, easily access an intervention set for harder moments, and efficiently facilitate administrative tasks. The desire to be able to customize bCBT protocols to individual patient circumstances was evident in both patient and therapist interviews. Patients differed with respect to what content and the amount of material the app should focus on as well as the method of recording experiences. Therapists viewed digital apps as potentially aiding in their documentation work outside of sessions. Different attitudes surfaced on the topic of data security, with patients not as concerned as therapists.

Conclusions

Both patients and therapists had substantially positive attitudes toward the option of an integrated bCBT treatment. Our study presents novel findings on the expectations and attitudes of patients and therapists.
Factors Associated With the Acceptance of an eHealth App for Electronic Health Record Sharing System: Population-Based Study
Authors: Huang Junjie , Pang Wing Sze , Wong Yuet Yan , Mak Fung Yu , Chan Florence S W , Cheung Clement  S K , Wong Wing Nam , Cheung Ngai Tseung , Wong Martin C S
Published: November 2022

Background

In the second stage of the Electronic Health Record Sharing System (eHRSS) development, a mobile app (eHealth app) was launched to further enhance collaborative care among the public sector, the private sector, the community, and the caregivers.

Objective

This study aims to investigate the factors associated with the downloading and utilization of the app, as well as the awareness, perception, and future improvement of the app.

Methods

We collected 2110 surveys; respondents were stratified into 3 groups according to their status of enrollment in the eHRSS. The primary outcome measure was the downloading and acceptance of the eHealth app. We collected the data on social economics factors, variables of the Technology Acceptance Model and Theory of Planned Behavior. Any factors identified as significant in the univariate analysis (P<.20) will be included in a subsequent multivariable regression analysis model. All P values ≤.05 will be considered statistically significant in multiple logistic regression analysis. The structural equation modeling was performed to identify interactions among the variables.

Results

The respondents had an overall high satisfaction rate and a positive attitude toward continuing to adopt and recommend the app. However, the satisfaction rate among respondents who have downloaded but not adopted the app was relatively lower, and few of them perceived that the downloading and acceptance processes are difficult. A high proportion of current users expressed a positive attitude about continuing to adopt and recommend the app to friends, colleagues, and family members. The behavioral intention strongly predicted the acceptance of the eHealth app (β=.89; P<.001). Attitude (β=.30; P<.001) and perceived norm; β=.37; P<.001) played important roles in determining behavioral intention, which could predict the downloading and acceptance of the eHealth app (β=.14; P<.001).

Conclusions

Despite the high satisfaction rate among the respondents, privacy concerns and perceived difficulties in adopting the app were the major challenges of promoting eHealth. Further promotion could be made through doctors and publicity. For future improvement, comprehensive health records and tailored health information should be included.
Ставропольские шереты в контексте советской национальной политики в 1920–1930-е гг.
Authors:   Southern Federal University (105/42 Bolshaya Sadovaya St., 344006 Rostov-on-Don, Russian Federation), Averyanov Anton V.
Published: November 2022

Introduction. In the 1920s and 1930s, one of the most important directions of Soviet nationalities policy was the building of Soviet nations on the basis of various ethnic groups. Utmost difficulties were to be faced when it came to identify small dispersed ethnic communities located in ethnocultural ‘borderlands’. In Stavropol Region, one such community were Sherets to have emerged as a result of historical synthesis of Kalmyk and Turkmen cultures and ethnic environments. Goals. The article seeks to analyze government policies towards Sherets and attempts a scientific understanding of their phenomenon in the Soviet era. Materials. The study examines archival documents housed by the State Archive of the Russian Federation, as well as other archival papers and published sources. Results. The work delineates main approaches to the study of Sherets in the prerevolutionary and Soviet periods. It shows that religion was chosen as a key identification factor for the group by Russian ethnographers and officials, which made it logical enough to cluster Stavropol Sherets with Turkmens. However, the Soviet approach rested on the primacy of primordialism and actual ethnic origins, and proclaimed Sherets an integral part of the Kalmyk people. The paper reveals main directions and mechanisms of work among Sherets at municipal, regional, and republican levels aimed at their rehabilitation and relocation to the native village of Kucherli in Turkmensky District. It is proved that Sherets — despite small numbers — sought to retain their identity based on clan system. The 1930s curtailment of the korenization policy resulted in accelerated assimilation of Sherets into the Turkmen population.
Влияние географических факторов на территориально-организационную структуру и хозяйственную деятельность Прорвинского (Астраханского) исправительно-трудового лагеря (1932–1950)
Authors:   Dosmukhamedov Atyrau University (1, Studenchesky Ave., 060011 Atyrau, Republic of Kazakhstan), Akhmetova Ulzhan T. , Imashev Eduard Zh. , Muktar Abilseiit K. ,   Mahambet Otemiusly West Kazakhstan University (162, Nazarbayev Ave., 090000 Oral, Republic of Kazakhstan),   State Historical and Cultural Museum-Reserve “Saraishyq” (11, Myrzagali St., 060707 Sarayshyq, Republic of Kazakhstan)
Published: November 2022

Introduction. Since vectors of natural resources, construction and infrastructure development across the vast Soviet territories (including that of the Kazakh SSR) were determined by geographical aspects of correctional labor camps’ territorial organization, it was the geographical factor that proved crucial to the shaping of camps system proper. So, an insight into experiences of the Prorva (Astrakhan) Correctional Labor Camp is of certain interest. Goals. The study aims at assessing impacts of geographical factors on the shaping and functioning of the mentioned labor camp’s territorial organizational structure and economic activity between 1932 and 1950. Materials and methods. The work explores documents housed by the State Archive of the Russian Federation, Archive of Internal Affairs Ministry Department in Astrakhan Oblast, outcomes of history and geography research expeditions to Mangystau and Atyrau Regions of Kazakhstan undertaken in July 2021, geographical maps. The study employs a variety of research methods, such as general scientific (analysis, synthesis, mathematical and descriptive techniques), geographical (analytical tools of cartography, comparative, physical and economic geography, expeditionary, system territorial, and factorial methods) and historical (retrospective, comparative, structural approaches) ones. Results. The paper presents a geographical analysis of six localities, reveals territorial organizational structure of the camp (the latter to have covered northern and northeastern parts of the Caspian coastline), provides an assessment of physical and geographical conditions of the camp’s economic arrangements. The latter had predetermined the availability of rich biological sea resources. However, in general, the physical and geographical components of natural environment were unfavorable (arid climate, infertile soil cover, sparse vegetation) for commercial agricultural production. The study of economic and geographical factors shows different economic potentials across localities of the camp. The economic geographical factors resulted in the shaping and functioning of a territorial organizational structure primarily aimed at efficient industrial fishing practices. Conclusions. The geographical factors proved of utmost importance and served a basis for the development of fisheries in the northern and northeastern parts of the Caspian Sea. In addition, efforts were made to initiate agricultural production and construction activities that still were to play a secondary economic role due to unfavorable conditions.
Некоторые вопросы исследования сочинения «Sumagadha-avadāna» в отечественном и зарубежном востоковедении (на материале «Легенды о Сайн Магаде» из Монгольского Ганджура)
Authors:   Kalmyk Scientific Center of the RAS (8, Ilishkin St., 358000 Elista, Russian Federation), Muzraeva Delyash N.
Published: November 2022

Introduction. The Sumagadha-Avadāna (‘Avadāna of Sumagadha’) is often mentioned in Oriental studies, including works on the history of classical Mongolian literature examining writings of Indo-Tibetan origin. This text is included in both the Tibetan- and Mongolian-language canonical Kangyur (Kanjur) editions. Despite frequent references, the former has neither been translated into Russian, nor there are any descriptions of its structure and content. Goals. So, the article attempts to fill the gap and aims at considering the narrative about Sayin Magada through the analysis of The Legend of Sayin Magada (Mong. Sayin Magada-yin domuγ), the latter being integral to the canonical collection of Kanjur in Mongolian. The work explores the text, describes its genre characteristics, identifies its structure, reveals contents, and investigates data contained in the colophon. Materials. The study focuses on the text titled ‘Sayin Magada-yin domuγ-i ögülegči kemekü’ (‘[Sutra] Narrating the Legend of Sayin Magada’) from the Eldeb (‘Collection of Sutras’) section of the Mongolian Kanjur (vol. 91). Results. The textual and content analysis of works by Tibetologists, Mongolists, and Sinologists dealing with writings of the avadāna genre included in the canon makes it possible to reveal key characteristics of the genre, describe the structure of the Mongolian text, and outline its content.
Закон об отмене обязательных отношений между отдельными сословиями калмыцкого народа как исторический источник
Authors:   Gorodovikov Kalmyk State University (11, Pushkin St., 358000 Elista, Russian Federation), Matsakova Natalya P.
Published: November 2022

Introduction. The article provides a source analysis of the Law of 16 March 1892. Despite there are works dealing with the reform initiated by the act, there is no analysis of the document as a historical source. Goals. So, the paper attempts such a comprehensive insight into the Law. Materials and methods. The key method employed is that of source studies with due involvement of analysis and synthesis tools. The document is also examined with the use of techniques and approaches inherent to investigations of normative legal acts. Results. It is proper enough to identify the examined source as a law with legal force. Its adoption was determined by a number of socioeconomic and political prerequisites and reasons. The draft law was developed by committees and councils specially established within the Ministry of State Property. The preparatory process lasted for three decades to be attended by officials of most various levels. Furthermore, the nature and essentials of the Law were influenced by the events of 1881. The Law of 16 March 1892 was being implemented for almost three years but consequences of the reform to have intensified socioeconomic and sociopolitical processes in the region had far more significant and lasting effects. Historiography of the reform attests to that there still is an interest in the Law arising from its significance. Conclusions. The source analysis shows the Law of 16 March 1892 be classified as a public legislative act. Its development and adoption are integral to the reform process witnessed by Russia in the 1860s–1870s. The Law contributed to modernization of Kalmyk society and opened a new phase in Kalmyk history, changed lives of thousands of Kalmyk commoners granting them rights of free rural inhabitants. Undoubtedly, its significance as a historical source deserves particular attention and recognition.
Нижнепалеолитическая стоянка-мастерская Кусимово-8 (Южное Зауралье)
Authors:   Institute of History, Language and Literature of the Ufa Federal Research Centre of the RAS (71, Oktyabrya Ave., 450054 Ufa, Russian Federation), Kotov Viacheslav G. , Savelev Nikita S.
Published: November 2022

Introduction. Comprehensive and efficient investigations of the earliest peopling of the Southern Urals became possible after the discovery of Mysovaya site in Abzelilovsky District of Bashkortostan (Russia). The Paleolithic materials from this site were considered mixed — Acheulean/Mousterian — or Mousterian proper. In recent years, the Lower and Middle Paleolithic site of Kusimovo-8 has been discovered nearby. This is a scattered workshop site on pebble flint outcrops within the terrace surface of the Bannoe-Sabakty paleolake. Goals. The study attempts an insight into the earliest peopling of the Southern Urals, describes and analyzes the Lower Paleolithic collection. Results. The finds were identified on the basis of technical and typological characteristics and preservation parameters. The collection comprises a total of 121 items, most of the objects made of flint pebbles and only two bifaces made of diabase. Nucleuses with patinated surfaces (19 items) are diverse enough: mainly flat cores of parallel and sub-parallel shearing are available to be quantitatively followed by radial, fan-shaped, and orthogonal cores. The tools are represented by oval and almond-shaped hand axes, cleavers, piked tools, a chopper, biface blanks, and various side-scrapers. The stratigraphy of test pits shows the presence of two cultural horizons: flint chips were found under the Middle Paleolithic cultural layer (grayish-brown loam with dolomite gravel) — 0.5 m lower in yellowish-brown loam. Paleoecological analyses of the pits attest to that yellowish-brown loam deposits can be dated to the Middle Pleistocene. Similar conditions were identified for Lower Paleolithic finds discovered at Mysovaya site. Similarity of both the sites makes it possible to conclude as to comparable ages of these collections and that they may cluster together within one Karyshkino-type industry which unites a majority of Lower Paleolithic sites across the Southern Transurals, all of them to form a specific variant of the Tayacian.
Factores de modificación por comportamiento degradante por espectros de diseño sísmico
Authors:   Instituto de Ingeniería, UNAM, Ruiz Gómez Sonia Elda , Rodríguez Castellans Ali Abraham ,   Instituto de Ingeniería, UNAM
Published: November 2022

El análisis dinámico modal espectral es ampliamente utilizado en el diseño sísmico de edificaciones. Este tipo de análisis generalmente define la acción símica mediante un espectro de pseudoaceleraciones elástico, cuyas ordenadas pueden alterarse por medio de factores de modificación de resistencia; existen, por ejemplo, factores de modificación por ductilidad, sobrerresistencia, redundancia, irregularidad, asimetría en fluencia, etc. En el presente estudio se propone una metodología orientada a obtener factores de modificación de resistencia para considerar el efecto de degradación estructural, aplicables a espectros de sitio de diseño sísmico de la Ciudad de México (CDMX). La metodología se basa en análisis probabilistas de peligro sísmico (APPS) utilizando dos medidas de intensidad sísmica: a) Sa(T1), la cual representa la aceleración espectral en el periodo fundamental de una estructura, y b) INp, que considera el alargamiento del periodo fundamental que presenta la estructura como consecuencia de la degradación estructural. Primeramente, se estiman espectros de peligro uniforme, correspondientes a diferentes sitios de la CDMX, en términos de Sa(T1) y, alternativamente, de INp, los cuales representan la respuesta de sistemas con comportamiento no degradante y degradante, respectivamente. Enseguida, a través del cociente entre dichos espectros INp/Sa(T1), se obtienen factores de modificación de resistencia, sin la necesidad de realizar análisis no-lineales. Finalmente, se ajusta una expresión matemática a dichos cocientes espectrales, aplicable a estructuras desplantadas sobre diferentes tipos de terreno de la CDMX. La expresión propuesta se compara con resultados de otras investigaciones basados en análisis no-lineales tiempo-historia
Influencia Estructural de Disipadores SLB para Muros Desacoplados en Estructuras de Concreto Armado y Arriostramientos en Estructuras Metálicas
Authors:   Universidad Politécnica Salesiana, Brito-Tapia Jorge Alexander , Terán Coloma Ramiro Alejandro ,   Universidad Politécnica Salesiana, Guerrero Cuasapaz David Patricio ,   Universidad Politécnica Salesiana
Published: November 2022

Los disipadores Shear Link Bozzo (SLB) actúan en el rango no lineal con el fin de generar una deformación en el dispositivo, previniendo daños estructurales en las edificaciones, por tal motivo, es importante realizar un análisis no lineal tiempo-historia mínimo con tres eventos sísmicos representativos del Ecuador, y así obtener las características fundamentales de cada estructura, conociendo el comportamiento sismorresistente de los dispositivos en el país. Es por ello que, en el presente estudio se realizó un análisis comparativo no lineal tiempo-historia usando disipadores de energía SLB frente a métodos constructivos tradicionales, tanto en concreto armado como en estructura metálica, con el fin de determinar qué sistema presenta un mejor comportamiento con dichos dispositivos. De esta manera, se modelaron dos edificios con diferentes características arquitectónicas, que generaron un total de ocho estructuras; cuatro de ellas en concreto armado y cuatro en estructura metálica, de las cuales dos correspondieron a estructura con método tradicional y dos con la implementación de disipadores SLB. Los resultados que se generaron en ambos sistemas constructivos, demuestran que los disipadores de energía SLB disminuyen dichas características fundamentales, principalmente el cortante máximo de piso, donde la reducción fue mayor al 75 % en ambos casos.
Peran Model Pengembangan Pariwisata Berbasis Masyarakat (Community Based Tourism) Dalam Mewujudkan Pariwisata Berkelanjutan (Sustainable Tourism) di Bali
Authors: Permatasari Indah
Published: November 2022

Industri pariwisata merupakan kumpulan usaha pariwisata yang saling terkait yang bertujuan untuk memenuhi kebutuhan wisatawan dalam penyelenggaraan pariwisata. Tentu saja dalam rangka memenuhi kebutuhan wisatawan dalam penyelenggaraan pariwisata dibutuhkan kerjasama dari dari berbagai pihak baik masyarakat setempat, pemerintah, pemerintah daerah, maupun pengusaha pariwisata. Masyarakat setempat memiliki peran yang penting khususnya bagi pengembangan industri pariwisata. Bahkan dalam ketentuan Pasal 5 Undang-Undang Nomor 10 Tahun 2009 tentang Kepariwisataan dapat diketahui prinsip dalam penyelenggaraan kepariwisataan salah satunya ialah memberdayakan masyarakat setempat. Permasalahan yang kemudian muncul ialah terkadang pengembangan industri pariwisata tidak diarahkan pada pengembangan pariwisata yang berkelanjutan. Hal ini ditunjukkan dengan adanya beberapa fasilitas penunjang pariwisata yang dibangun tidak sesuai dengan peruntukannya. Penelitian ini merupakah penelitian hukum empiris yang menggunakan data primer maupun sekunder yang bertujuan untuk mengetahui peran model pengembangan pariwisata berbasis masyarakat (community based tourism) dalam mewujudkan pariwisata berkelanjutan (sustainable tourism) di Bali. Hasil dari penelitian ini menujukkan bahwa model pengembangan pariwisata berbasis masyarakat menekankan pada peran atau partisipasi aktif masyarakat dalam mengembangkan pariwisata. Bahkan salah satu tujuan dari pariwisata berbasis masyarakat ini ialah untuk mewujudkan pembangunan pariwisata berkelanjutan. Masyarakat setempat memiliki peran yang sangat penting untuk mewujudkan pariwisata berkelanjutan (sustainable tourism). Peran dari pemerintah, pemerintah daerah, maupun pengusaha pariwisata juga sangat dibutuhkan untuk mewujudkan pariwisata berkelanjutan (sustainable tourism).
POLA SPASIAL PERTUMBUHAN KAWASAN PERMUKIMAN DI DESA DALUNG
Authors: I Wayan Candrapraleka Putra W  , Ngakan Ketut Acwin Dwijendra  , I Dewa Gede Agung Diasana Putra
Published: November 2022

Peningkatan jumlah penduduk dapat menyebabkan peningkatan jumlah kebutuhan ruang sedangkan peningkatan jumlah kebutuhan ruang dapat memicu pertumbuhan dan perkembangan sebuah kawasan. Pertumbuhan juga dialami oleh Desa Dalung dengan potensi yang mencirikan embrio suatu perkotaan di antaranya memiliki aksessibilitas yang sangat tinggi. Dengan demikian perkembangan di masa depan Desa Dalung akan mengalami pemadatan permukiman yang akan memicu munculnya pertumbuhan kawasan kumuh dan kemacetan lalu lintas di masa yang akan mendatang. Untuk itu penelitian ini bertujuan untuk menganalisis pola pertumbuhan kawasan permukiman di Desa Dalung. Metode penelitian yang digunakan yaitu deskriptif kualitiatif untuk menggambarkan pola spasial pertumbuhan kawasan permukiman di Desa Dalung. Analisis yang digunakan yaitu analisis morfologi, yang digunakan untuk mengidentifikasi ruang fisik yang ada di Desa Dalung. Jenis data yang akan digunakan dalam penelitian ini yaitu jenis data primer dan data sekunder. Hasil dari analisis penelitian ini menunjukkan bahwa pola pertumbuhan kawasan permukiman di Desa Dalung dilihat dari bentuk keruangan morfologi kota yang cenderung berbentuk gurita karena dipengaruhi oleh perkembangan jalur transportasi yang ada, sedangkan perkembangan morfologi kawasan permukiman di Desa Dalung cenderung lebih mengarah pada bentuk memanjang/ribbon, karena perkembangan permukiman di Desa Dalung terjadi karena adanya jalur transportasi.
Effectiveness of Agricultural Insurance Program as A Sustainable Agricultural Development Effort
Authors: Nyoman Yudiarini , Luh Putu Kirana Pratiwi  , Made Budiasa
Published: November 2022

In an effort to develop agriculture, especially as a protection for farmers against crop failure, the provincial government of Bali through the National Food Security program has established Badung Regency as a pilot project for implementing agricultural insurance through the Jasindo Insurance Company. This concept is applied as a guarantee for farmers in terms of price fluctuations of agricultural products that tend to decline, thus triggering the reduction of agricultural terrain that increases each year in Bali Province. This study goals to analyse the level of effectiveness of the agricultural insurance program and to analyze the factors that affect the level of effectiveness of the insurance program as an attempt to develop sustainable agriculture in Bongkasa Village, Abiansemal Region, Badung Regency. The method of analysis in this research is done quantitatively, namely this study uses two analyzes, namely descriptive analysis which is used to analyze the level of effectiveness of agricultural insurance programs and Confirmatory Factor Analysis which is used to confirm latent variables and indicators. The results of the analysis show that the level of effectiveness of the agricultural insurance program is 81.75 percent with effective criteria. The variable that has a dominant affect on the performance of the insurance program as an effort to develop sustainable agriculture is the process variable which is then followed by the output variable and the input variable.
Mangosteen Agribusiness Partnership In PT. Radja Manggis Sejati, Padangan Village, Tabanan Regency
Authors: Luh Putu Kirana Pratiwi  , Nyoman Yudiarini  , Ida Ayu Made Dwi Susanti
Published: November 2022

One of the agricultural sub-sectors that apply the mangosteen commodity partnership pattern in Bali is STA Sari Buah with PT Radja Manggis Sejati in Padangan Village, Pupuan District, Tabanan Regency. The development of partnerships can help farmers and business actors in increasing the growth of horticultural agribusiness, especially in the mangosteen commodity. The marketing partnership pattern for the mangosteen commodity is based on a written agreement, but the marketing contract is made between suppliers and farmer groups with exporter companies. Responsibilities of partner groups, namely: taking an inventory of group members and mangosteen trees, cultivating mangosteen properly, collecting mangosteen from farmers, sorting and grading with partner company officers, selling mangosteen to partner companies, and repaying capital loans by deducting from the proceeds of mangosteen sales. . The rights of partner group members are to obtain loans, to be able to supply mangosteen to partner companies, to obtain prices according to the prevailing market prices, to receive payments by bank transfer as soon as the goods are received by the partner companies, and to receive a fee for each kilogram of mangosteen deposited.
Pengaruh Disiplin dan Motivasi Kerja pada Kinerja Karyawan pada Biro Bamakermas, Universitas Warmadewa
Authors: Pratami Ni Wayan Cahya Ayu
Published: November 2022

This study aims to analyze the effect of motivation and work discipline on employee performance at the BAMAKERMAS Bureau, Warmadewa University. The research data were obtained from questionnaires, observations and related literature studies according to the research objectives. The analysis technique uses multiple linear regression with hypothesis testing, namely the T test. The number of samples is 35 respondents using the incidental sampling technique. The results showed that the variables of Motivation and Work Discipline had a significant effect either partially or simultaneously on performance at the BAMAKERMAS Bureau, Warmadewa University.
DISTRIBUTION OF TRAVEL INSURANCE USER AMONG TRAVELERS VISITING BALI, INDONESIA
Authors: Apsari Putu Indah Budi , Suryanditha Putu Arya
Published: November 2022

Travel insurance is important to protect travelers to various travel risk and health problem. But because of financial condition and lack of knowledge to protect their safety while traveling, the use of travel insurance is very low. This research aim to assess distribution of travel insurance user among travelers especially who visiting Bali as their destination trip. This is cross-sectional study using medical record of foreign travelers visiting international hospital. Result show most travelers have no travel insurance (70%) compared with people take travel insurance for their safety vacation. Based on age, there are no significance difference between age group 0-18 years, 19-64 years dan more that 65 years, approximately the youngest people the lack of awareness to buy travel insurance. Based on health problem the distribution of travelers with no travel insurance tend to be same on average 60-80%. As conclusion the use of travel insurance remains low, furthermore all travelers must be encouraged to use travel insurance for their safety.