bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of Oral Supplementation of Different Levels of Tamoxifen on Productive and Reproductive Efficiencies and Carcass Traits of Avian48 and Arbor Acres Broilers
Authors: Younis Mona E.M. , Aboelnour Asmaa , Swelum Ayman A. , Ghoneim Hanan A. , Abd El-Hack Mohamed E. , Khafaga Asmaa F. , Al-Ghadi Muath Q. , Al-Himadi Ahmed R. , Almutairi Bader O. , Ammari Aiman A. , Ghanima Mahmoud M. Abo
Published: August 2020

This research was aimed at estimating the effect of oral supplementation of Tamoxifen on productive efficiency, carcass characteristics, hormonal profile and gonadal structure of two broiler breeds. One hundred and eighty chicks of each breed of Avian48 and Arbor Acres were divided into three groups: control group; TAM10 group, supplied with 10 mg Tamoxifen/kg of body weight at 3, 5, 7 and 9 days of life; and TAM20 group, supplied at the same intervals with 20 mg Tamoxifen/kg of body weight. Both levels of Tamoxifen improved productive performance at early ages, but Arbor Acres produced better results with TAM20 levels than TAM10, while Avian48 breeds reacted adversely. On the contrary, Tamoxifen supplementation significantly decreased feed intake and feed conversion (after the first two weeks of life) compared to control with a higher level of decrease reported for TAM20 treatments than TAM10 and for Arbor Acres compared to Avian48 breed. Carcass traits were not affected significantly with Tamoxifen supplementation compared to control although Arbor Acres responded better to TAM20 and Avian48 for TAM10. With regard to the effect of Tamoxifen (TAM) on sex hormones, it could be concluded that TAM10 treatments showed a stimulating effect on the level of such hormones as compared with the TAM20 group with the most favourable results being clearly detectable in 42-day-old birds although both concentrations of Tamoxifen did not differ significantly from control. However, treatment of broiler chickens with Tamoxifen in different doses caused a gradual decrease in follicle production rate and eventually led to an increase of the atretic follicles in different stages of atresia. Finally, we can conclude that Tamoxifen supplementation can improve performance and carcass efficiency of broilers without changing the hormonal profile, however much research is required to estimate the best concentration required for each breed.
Time Course-Dependent Study on Equine Herpes Virus 9-Induced Abortion in Syrian Hamsters
Authors: Abas Osama , Abdo Walied , Kasem Samy , Alwazzan Abdulatif , Saleh Asmaa G. , Saleh Ibrahim G. , Fukushi Hideto , Yanai Tokuma , Haridy Mohie
Published: August 2020

This study aimed to follow the time-course pathogenesis of EHV-9 abortion in early and late trimesters. Twenty-seven pregnant hamster dams were divided into three groups: (G1) control, (G2) EHV-9-inoculated on the 5th day (early trimester), and (G3) EHV-9-inoculated on the 10th day of gestation (late trimester). Dams were sacrificed at different time points during gestation and examined for viremia and viral DNA in different fetal and maternal tissues and pathological changes in fetal tissue, placenta, and cytokines. Animals in G3 showed a marked increase in the number of dead fetuses than those in G2. Histopathological findings of G2 showed early band coagulative necrosis of maternal spaces and stromal decidual cells. Necrotic changes were observed within the decidua basalis, spongiotrophoblast layer, and labyrinth. First, the virus was localized within mononuclear leukocytes in the decidua capsularis and basalis, and within the necrotic chorionic villi and cervical epithelium. G3 demonstrated degenerative changes within the chorionic villi and trophospongium. The virus antigen was observed within the chorionic villi, trophoblasts, mononuclear cells, and fetal tissues. In conclusion, EHV-9 induced abortion mostly occurs through necrosis of the chorionic villi and cannot cross through the capsular placenta in the early trimester but can through the developed decidual placentation.
Novel Encapsulated Calcium Butyrate Supplement Enhances On-Farm Dairy Calf Growth Performance and Body Conformation in a Pasture-Based Dairy Production System
Authors: Malau-Aduli Aduli Enoch Othniel , Balogun Razaq Oladimeji , Otto John Roger , Verma Sumita , Wehella Maduka , Jones David
Published: August 2020

The effect of supplementing neonatal heifer calves with varying levels of ECAB on pre-weaning growth performance was investigated. Post-weaning growth was also measured, to determine any carry-over effect of pre-weaning supplementation of ECAB. Forty-eight heifer calves (7 ± 0.4 days old, average liveweight of 39.3 ± 5.3 kg) were utilized in a complete randomised experimental design, comprising 16 calves per pen, randomly allocated to one of the following three treatments: (1) Basal commercial calf starter mix without ECAB (Control); (2) control plus 4 kg/ton of ECAB (Low); and (3) control plus 6 kg/ton of ECAB (High). Calves were group-fed ad libitum for 77 days (11 weeks, pre-weaning period) with free choice access to water and 5.5 L of milk per head per day through an automated feeder. Calves were weighed weekly during the pre-weaning period, after which all calves were then weaned onto the same ryegrass pasture as one group. At approximately 9 months of age, calves were weighed to estimate post-weaning body weight gain. During the pre-weaning period, average daily dry matter feed intake was similar for 4 kg/ton and 6 kg/ton calves (649 g versus 688 g, respectively) and both were greater than that of the control calves (382 g). Average daily gain (ADG) was significantly higher for 4 kg/ton calves compared to 6 kg/ton calves or control calves (0.83 ± 0.03 kg, 0.74 ± 0.03 kg and 0.71 ± 0.03 kg, respectively; p = 0.0001). Similarly, 4 kg/ton calves had significantly increased chest girth (95.9 ± 0.7 cm), withers height (88.9 ± 0.5 cm), body length (82.9 ± 0.6 cm), and body condition score (1.99 ± 0.12) compared to 6 kg/ton calves (93.4 ± 0.7 cm, 87.4 ± 0.7, 81.5 ± 0.6 cm, and 1.67 ± 0.10, respectively) or control calves (92.9 ± 0.7 cm, 88.2 ± 0.5 cm, 80.1 ± 0.6 cm, and 1.30 ± 0.08, respectively). There was significant treatment × week interaction for all pre-weaning growth parameters. Breed differences were detected but there was no treatment × breed interaction. Post-weaning, 4 kg/t calves and 6 kg/t calves had significantly higher ADG compared to control calves (0.80 ± 0.03 kg, 0.85 ± 0.03 kg versus 0.70 ± 0.03 kg, respectively; p = 0.0047). It is concluded that under the conditions of this study, supplementing heifer calves with ECAB during pre-weaning period resulted in improved growth performance and there appears to be a post-weaning carry-over effect.
The Milk Thistle Seed Cakes and Hempseed Cakes are Potential Feed for Poultry
Authors: Stastnik Ondrej , Pavlata Leos , Mrkvicova Eva
Published: August 2020

The aims of this work were to summarize the nutritional value of the milk thistle seed cakes and hempseed cakes and describe the influence on selected performance parameters, metabolism and animal health from inclusion of these non-traditional feeds into diets. It seems more appropriate to apply the extract of the bioactive substances complex to the livestock diets than addition of expellers or other forms of plants processing. The seed expellers, etc. mostly worsened the chickens’ performance parameters with higher doses in diets, while most of the work using the extract yields had positive results on animal performance.
Effects of Olfactory and Auditory Enrichment on Heart Rate Variability in Shelter Dogs
Authors: Amaya Veronica , Paterson Mandy B.A. , Descovich Kris , Phillips Clive J.C.
Published: August 2020

Animal shelters can be stressful environments and time in care may affect individual dogs in negative ways, so it is important to try to reduce stress and arousal levels to improve welfare and chance of adoption. A key element of the stress response is the activation of the autonomic nervous system (ANS), and a non-invasive tool to measure this activity is heart rate variability (HRV). Physiologically, stress and arousal result in the production of corticosteroids, increased heart rate and decreased HRV. Environmental enrichment can help to reduce arousal related behaviours in dogs and this study focused on sensory environmental enrichment using olfactory and auditory stimuli with shelter dogs. The aim was to determine if these stimuli have a physiological effect on dogs and if this could be detected through HRV. Sixty dogs were allocated to one of three stimuli groups: lavender, dog appeasing pheromone and music or a control group, and usable heart rate variability data were obtained from 34 dogs. Stimuli were applied for 3 h a day on five consecutive days, with HRV recorded for 4 h (treatment period + 1 h post-treatment) on the 5th and last day of exposure to the stimuli by a Polar® heart rate monitor attached to the dog’s chest. HRV results suggest that music activates both branches of the ANS, which may be useful to relieve both the stress and boredom in shelter environments.
Efficacy and Gut Dysbiosis of Gentamicin-Intercalated Smectite as a New Therapeutic Agent against Helicobacter pylori in a Mouse Model
Authors: Jeong Su Jin , Lee Kyoung Hwa , Kim Jie-Hyun , Park Soon Young , Song Young Goo
Published: August 2020

Helicobacter pylori eradication rate with conventional standard therapy is decreasing owing to antibiotic resistance, necessitating novel antibacterial strategies against H. pylori. We evaluated the efficacy of a gentamicin-intercalated smectite hybrid (S-GM)-based treatment and analyzed fecal microbiome composition in H. pylori-infected mice. To evaluate anti-H. pylori efficacy, mice were divided into eight groups, and H. pylori eradication was assessed by a Campylobacter-like organism (CLO) test and PCR assay of H. pylori in gastric mucosa. One week after H. pylori eradication, pro-inflammatory cytokine levels and atrophic changes in gastric mucosa were examined. Stool specimens were collected and analyzed for microbiome changes. The S-GM-based triple regimen decreased bacterial burden in vivo, compared with that in untreated mice or mice treated with other regimens. The therapeutic reactions in the CLO test from gastric mucosa were both 90% in the standard triple therapy and S-GM therapy group, respectively. Those of H. pylori PCR in mouse gastric mucosa were significantly lower in standard triple therapy and S-GM therapy groups than in the non-treatment group. Toxicity test results showed that S-GM therapy reduced IL-8 level and atrophic changes in gastric mucosa. Stool microbiome analysis revealed that compared with mice treated with the standard triple therapy, mice treated with the S-GM therapy showed microbiome diversity and abundant microorganisms at the phylum level. Our results suggested that S-GM is a promising and effective therapeutic agent against H. pylori infection.
Counteracting Cisplatin-Induced Testicular Damages by Natural Polyphenol Constituent Honokiol
Authors: Wang Tse-En , Lai Yu-Hua , Yang Kai-Chien , Lin Sung-Jan , Chen Chih-Lin , Tsai Pei-Shiue
Published: August 2020

Cisplatin, despite its anti-cancer ability, exhibits severe testicular toxicities when applied systemically. Due to its wide application in cancer treatment, reduction of its damages to normal tissue is an imminent clinical need. Here we evaluated the effects of honokiol, a natural lipophilic polyphenol compound, on cisplatin-induced testicular injury. We showed in-vitro and in-vivo that nanosome-encapsulated honokiol attenuated cisplatin-induced DNA oxidative stress by suppressing intracellular reactive oxygen species production and elevating gene expressions of mitochondrial antioxidation enzymes. Nanosome honokiol also mitigated endoplasmic reticulum stress through down regulation of Bip-ATF4-CHOP signaling pathway. Additionally, this natural polyphenol compound diminished cisplatin-induced DNA breaks and cellular apoptosis. The reduced type I collagen accumulation in the testis likely attributed from inhibition of TGFβ1, αSMA and ER protein TXNDC5 protein expression. The combinatorial beneficial effects better preserve spermatogenic layers and facilitate repopulation of sperm cells. Our study renders opportunity for re-introducing cisplatin to systemic anti-cancer therapy with reduced testicular toxicity and restored fertility.
The Potential of Sulfated Polysaccharides Isolated from the Brown Seaweed Ecklonia maxima in Cosmetics: Antioxidant, Anti-melanogenesis, and Photoprotective Activities
Authors: Wang Lei , Jayawardena Thilina U. , Yang Hye-Won , Lee Hyo-Geun , Jeon You-Jin
Published: August 2020

Sulfated polysaccharides prepared from marine algae are potential ingredients in nutraceutical, pharmaceutical, and cosmeceutical industries. In the present study, the antioxidant, anti-melanogenesis, and photoprotective effects of sulfated polysaccharides obtained from Ecklonia maxima (EMC) were investigated to evaluate their potential in cosmetic. EMC was successfully prepared through Celluclast-assisted extraction and ethanol precipitation, and it contained 79.88% of sulfated polysaccharides that with 69.37% carbohydrates and 10.51% sulfate. EMC effectively suppressed 2,2-azobis(2-amidinopropane) hydrochloride (AAPH)-induced oxidative stress in vitro in Vero cells and in vivo in zebrafish. Furthermore, EMC significantly inhibited mushroom tyrosinase and reduced melanin synthesis in alpha-melanocyte-stimulating hormone-stimulated B16F10 cells. In addition, EMC remarkably attenuated photodamage induced by UVB irradiation in vitro in human keratinocytes (HaCaT cells) and in vivo in zebrafish. Furthermore, EMC effectively inhibited wrinkle-related enzymes and improved collagen synthesis in UVB-irradiated human dermal fibroblasts (HDF cells). These results indicate that EMC possesses strong antioxidant, anti-melanogenesis, and photoprotective activities, and suggest that EMC may be an ideal ingredient in the pharmaceutical and cosmeceutical industries.
Acute Diarrhea in Dogs: Current Management and Potential Role of Dietary Polyphenols Supplementation
Authors: Candellone Alessia , Cerquetella Matteo , Girolami Flavia , Badino Paola , Odore Rosangela
Published: August 2020

Acute diarrhea is one of the most common reasons why pet owners seek veterinary care for their canine companions. In many cases, signs resolve spontaneously or with symptomatic therapy without a specific cause being discovered. However, life-threatening cases can occur. The etiology is complex, including infectious diseases (endoparasites, virus, bacteria, protozoa, fungal agents) by both zoonotic and non-zoonotic pathogens, dietary indiscretion, endocrine diseases, and stress (e.g., travel or environmental changes). In the last years, the role played by oxidative stress in the pathogenesis of acute and chronic enteropathies, independently from the initial noxa, has been highlighted by many researches in both humans and animals. As a result, a series of dietary antioxidant compounds have been studied for their potential use in the treatment of intestinal inflammation. This review summarizes the traditional therapeutic and nutritional options to manage canine acute diarrhea, highlighting the need to explore the role of oxidative stress and potential antioxidant supplementation, especially polyphenols, during acute diarrheic episodes.
Measurement of Wheel Radius in an Automated Guided Vehicle
Authors: Smieszek Miroslaw , Dobrzanska Magdalena , Dobrzanski Pawel
Published: August 2020

In the case of automated guided vehicles using odometry, a very important issue is to know the actual rolling radius of the wheel used to calculate the position of the vehicle. This radius is not constant. Its changes depend on the elastic deformation of the band layer and wheel slip. The theoretical determination of the value of the radius and the nature of the change is very difficult. For this reason, it was decided to determine the rolling radii by the experimental method. For this purpose, an appropriate test stand was built and the proposed research method was checked. Within the tests, there was also obtained a number of interesting results characterizing the material used to build bands and the ranges of changes rolling radii for the tested material were specified.
Bi-Directional Static Load Tests of Pile Models
Authors: Baca Michał , Brząkała Włodzimierz , Rybak Jarosław
Published: August 2020

This work examined a new method of bi-directional static load testing for piles, referencing the Osterberg test. Measurements were taken, on a laboratory scale, using six models of piles driven into a box filled with sand. This method allowed for separate measurements of pile base and pile shaft bearing capacities. Based on the results, the total pile bearing capacity and equivalent Q–s diagrams were estimated. The results obtained show that the structure of the equivalent curve according to Osterberg is a good approximation of the standard Q–s curve obtained from load tests, except for loads close to the limit of bearing capacity (those estimates are also complicated by the inapplicability and ambiguity of a definition of the notion of limit bearing capacity); the equivalent pile capacity in the Osterberg method represents, on average, about 80% of the capacity from standard tests.
Local CPG Self Growing Network Model with Multiple Physical Properties
Authors: Liu Ming , Li Mantian , Zha Fusheng , Wang Pengfei , Guo Wei , Sun Lining
Published: August 2020

Compared with traditional control methods, the advantage of CPG (Central Pattern Generator) network control is that it can significantly reduce the size of the control variable without losing the complexity of its motion mode output. Therefore, it has been widely used in the motion control of robots. To date, the research into CPG network has been polarized: one direction has focused on the function of CPG control rather than biological rationality, which leads to the poor functional adaptability of the control network and means that the control network can only be used under fixed conditions and cannot adapt to new control requirements. This is because, when there are new control requirements, it is difficult to develop a control network with poor biological rationality into a new, qualified network based on previous research; instead, it must be explored again from the basic link. The other direction has focused on the rationality of biology instead of the function of CPG control, which means that the form of the control network is only similar to a real neural network, without practical use. In this paper, we propose some physical characteristics (including axon resistance, capacitance, length and diameter, etc.) that can determine the corresponding parameters of the control model to combine the growth process and the function of the CPG control network. Universal gravitation is used to achieve the targeted guidance of axon growth, Brownian random motion is used to simulate the random turning of axon self-growth, and the signal of a single neuron is established by the Rall Cable Model that simplifies the axon membrane potential distribution. The transfer model, which makes the key parameters of the CPG control network—the delay time constant and the connection weight between the synapses—correspond to the axon length and axon diameter in the growth model and the growth and development of the neuron processes and control functions are combined. By coordinating the growth and development process and control function of neurons, we aim to realize the control function of the CPG network as much as possible under the conditions of biological reality. In this way, the complexity of the control model we develop will be close to that of a biological neural network, and the control network will have more control functions. Finally, the effectiveness of the established CPG self-growth control network is verified through the experiments of the simulation prototype and experimental prototype.
Surrogate Model Based Analysis of Inter-Ply Shear Stress in Fiber Reinforced Thermoplastic Composite Sheet Press Forming
Authors: Tullu Abera , Lee Bong-Sul , Hwang Ho-Yon
Published: August 2020

The anisotropic nature of fiber reinforced composite materials causes great challenges in predicting the inter-ply shear stress during forming. The complexity of understanding the functional dependency of inter-ply shear stress on multiple forming parameters such as blank temperature, pressure load, inter-ply slippage, and the relative fiber orientation angle of adjacent plies further limits the effort to produce a defect-free composite structure. Performing real experiments for various combinations of the mentioned parameters is both time consuming and economically costly. To overcome these difficulties, a surrogate-based analysis of inter-ply shear stress is proposed in this study. Based on the ranges of the forming parameters, computer experiments were performed. Using these experimental data, a radial basis function (RBF) based surrogate model that mimics inter-ply shear stress during composite press forming was developed. The fidelity of this model was checked with test data and found to be over 98% efficient.
Optimization and Validation of a Linear Appraisal Scoring System for Milk Production-Linked Zoometric Traits in Murciano-Granadina Dairy Goats and Bucks
Authors: Fernández Álvarez Javier , León Jurado Jose Manuel , Navas González Francisco Javier , Iglesias Pastrana Carlos , Delgado Bermejo Juan Vicente
Published: August 2020

Implementing linear appraisal systems (LAS) may reduce time, personnel and resource costs when performing large-scale zoometric collection. However, optimizing complex zoometric variable panels and validating the resulting reduced outputs may still be necessary. The lack of cross-validation may result in the loss of accuracy and value of the practices implemented. Special attention should be paid when zoometric panels are connected to economically-relevant traits such as dairy performance. This methodological proposal aims to optimize and validate LAS in opposition to the traditional measuring protocols routinely implemented in Murciano-Granadina goats. The sample comprises 41,323 LAS and traditional measuring records from 22,727 herdbook-registered primipara does, 17,111 multipara does and 1485 bucks. Each record includes information on 17 linear traits for primipara/multipara does and 10 traits for bucks. All zoometric parameters are scored on a nine-point scale. Cronbach’s alpha values suggest a high internal consistency of the optimized variable panels. Model fit, variability explanation power and predictive power (mean square error (MSE), Akaike (AIC)/corrected Akaike (AICc) and Bayesian information criteria (BIC), respectively) suggest the model comprising zoometric LAS scores performs better than traditional zoometry. Optimized reduced models are able to capture variability for dairy-related zoometric traits without noticeable detrimental effects on model validity properties.
Effects of Organic and Mineral Fertilization on Yield and Selected Quality Parameters for Dried Herbs of Two Varieties of Oregano (Origanum vulgare L.)
Authors: Matłok Natalia , Stępień Agnieszka Ewa , Gorzelany Józef , Wojnarowska-Nowak Renata , Balawejder Maciej
Published: August 2020

The purpose of the conducted study was to determine the effect of the applied organic and mineral fertilizer on the yield and the selected quality parameters of the obtained dried mass of Origanum vulgare L. A pot experiment was carried out involving two varieties of oregano (Aureum and Hot & Spicy), which were fertilized using organic and mineral fertilizer. The produced raw material underwent a drying process using the CPD-VMFD combination method, which involved convective pre-drying (40 °C and 0.8 m s−1) and vacuum-microwave finish drying at 240 W magnetron power. The resulting dry products were assessed in terms of color in CIE L * a * b * (Colour Ques spectrophotometer) and spectrophotometric analyses in order to determine the total content of polyphenols and antioxidant properties (ABTS and DPPH). Headspace solid phase micro-extraction (HS-SPME) from the obtained products was carried out, and their composition was determined by gas chromatography (GC-MS). The organic fertilizers used have resulted in the production of dry oregano herbs with a much higher bioactive potential than that of the herbs treated with material fertilizer. This phenomenon could be recognized as an elicitation effect associated with the use of common nettle extract. The organically fertilized oregano also contained an increased carvacrol content in the headspace, which resulted in a more intense odor of the dry herbs. The use of organic fertilizers in the cultivation of Origanum vulgare L. contributes to the production of raw material for direct consumption and drying, which has a higher bioactive potential and better organoleptic properties.
Laboratory Investigation of the Temperature-Dependent Mechanical Properties of a CRTS-Ⅱ Ballastless Track-Bridge Structural System in Summer
Authors: Zhou Lingyu , Yuan Yahui , Zhao Lei , Mahunon Akim Djibril Gildas , Zou Lifan , Hou Wenqi
Published: August 2020

To study the mechanical properties of the China Railway Track System type II (CRTS-II) ballastless slab track structure, a 1/4-scale specimen of a CRTS-II slab ballastless track-32-m standard prefabricated simply supported box girder bridge with three spans and two high-speed railway lines was developed. The mechanical properties of the structure under the action of daily natural temperatures were studied under the natural environmental conditions. The structural strain and relative interlayer displacements were analyzed. The results show that the temperature of the CRTS-II ballastless track-bridge structural system changes periodically every 24 h. The strain of the structural layers of the track system first increases and then decreases sinusoidally, and the internal strain of the track system lags along the vertical depth direction. The relative displacement between the layers of the ballastless track bridge structure system increases with the increase in temperature. The extreme value of the vertical relative displacement appears between the track bed and the bridge at section 1/4 in the span, so it should be paid attention to by the maintenance personnel. Due to the constraint of the shear slots, the structural strain and relative displacement at the fixed end near the shear slots are smaller than those at the sliding end. The mid-span deflection is the largest, and the overall deflection during the cooling phase is more significant than that during the heating phase.
Assessment of Accidental Torsion in Building Structures Using Static and Dynamic Analysis Procedures
Authors: Mohamed Osama Ahmed , Mehana Mohamed Sherif
Published: August 2020

This article presents the findings of a study on assessment of the increase in building’s response due to accidental torsion when subjected to seismic forces. Critical stiffness and geometrical parameters that define buildings torsional response are examined including: (1) the ratio, Ω, between uncoupled torsional frequency ωθ to uncoupled translation frequencies in the direction of ground motion ωx or ωy, (2) floor plan aspect ratio, b/r, which is a function of the floor dimension and radius of gyration. The increased response is assessed on symmetric multi-storey buildings using both static and dynamic analysis methods specified by ASCE-7 and considering parameters affecting the torsional response. It was concluded that static and dynamic analysis procedures predict different accidental torsion responses. Static analysis based on the Equivalent Lateral Force (ELF) method predicts more conservative accidental torsions responses for flexible structures with Ω < 0.7~0.80, while the responses are less conservative for stiffer buildings. The conservativism in static analysis method is attributed to the response amplification factor, Ax. Floor plans and their lateral support system having frequency ratio Ω = 1 will also have a torsional radius equal to radius of gyration, and will experience drop in torsional response relative to more torsionally flexible buildings. This article presents a procedure to overcome the shortcomings of static and dynamic analysis procedures in terms of estimating accidental torsion response of symmetric building structures.
Recommendation System Using Autoencoders
Authors: Ferreira Diana , Silva Sofia , Abelha António , Machado José
Published: August 2020

The magnitude of the daily explosion of high volumes of data has led to the emergence of the Big Data paradigm. The ever-increasing amount of information available on the Internet makes it increasingly difficult for individuals to find what they need quickly and easily. Recommendation systems have appeared as a solution to overcome this problem. Collaborative filtering is widely used in this type of systems, but high dimensions and data sparsity are always a main problem. With the idea of deep learning gaining more importance, several works have emerged to improve this type of filtering. In this article, a product recommendation system is proposed where an autoencoder based on a collaborative filtering method is employed. A comparison of this model with the Singular Value Decomposition is made and presented in the results section. Our experiment shows a very low Root Mean Squared Error (RMSE) value, considering that the recommendations presented to the users are in line with their interests and are not affected by the data sparsity problem as the datasets are very sparse, 0.996. The results are quite promising achieving an RMSE value of 0.029 in the first dataset and 0.010 in the second one.
4-Hexylresorcinol Administration Increases Dental Hard Tissue Formation and Incisor Eruption Rate in Rats
Authors: Kim Ji-Hwan , Kim Dae-Won , Kim Seong-Gon , Kim Tae-Woo
Published: August 2020

Dental hard tissue formation and bone turnover are required for tooth eruption. 4-Hexylresorcinol (4HR) accelerates tooth movement by increasing bone turnover in orthodontic treatment. This study aimed to evaluate the following: (1) the effect of 4HR application on the expression of proteins associated with tooth formation, and (2) the effect of 4HR application on mandibular incisor eruption rate in a rat model. Primary cultured pulp cells received either 4HR (1 to 100 µM) or solvent only; western blotting was performed for transforming growth factor-beta 1 (TGF-β1), bone morphogenic protein-2/4 (BMP-2/4), runt-related transcription factor 2 (Runx2), osterix (OSX), dentin sialophosphoprotein (DSPP), and parathyroid hormone-related protein receptor (PTHrP-R). In in vivo study, rats (15 males and 15 females) received either solvent or 0.128 mg/kg or 12.8 mg/kg of 4HR via subcutaneous injection; mandibular incisor eruption rate was subsequently recorded. Immunohistochemical staining and western blotting for TGF-β1, BMP-2/4, Runx2, OSX, DSPP, and PTHrP-R were performed in the mandibular tissue samples. 4HR administration was found to increase TGF-β1, BMP-2/4, Runx2, OSX, DSPP, and PTHrP-R expression in both cell culture and tissue samples. Immunohistochemical staining of some markers showed site-specific expression, thereby indicating programmed differentiation of odontoblasts and ameloblasts. The eruption rate was significantly higher in the 12.8 mg/kg 4HR-administered group than in the untreated control (p = 0.001 and 0.010 for males and females, respectively). Collectively, 4HR administration increased the expression of markers related to dental hard tissue formation and accelerated the eruption rate of incisors in rats.
Ground Subsidence Analysis in Tianjin (China) Based on Sentinel-1A Data Using MT-InSAR Methods
Authors: Li Dong , Hou Xiyong , Song Yang , Zhang Yuxin , Wang Chao
Published: August 2020

Multi-temporal InSAR (MT-InSAR) methods have been widely used in remote sensing monitoring of ground subsidence, which occurs at many places around the world. Land subsidence, caused by excessive extraction of groundwater, has always been a problem to be solved in Tianjin, China. Although the subsidence in the urban area has been controlled at a low rate, the subsidence issue has not been effectively solved in the suburban area recently, which should be paid much attention. This paper aims to present two multi-temporal differential interferometry techniques, persistent scatterer (PS) and small baseline subset (SBAS), for monitoring the latest surface subsidence in a Tianjin study area on the basis of 20 Sentinel-1A images obtained from March 2017 to March 2019. Our research showed that the average velocity map obtained from the SBAS method closely followed the outcomes of the PS technique from the perspective of identifying similar subsidence patterns. Subsidence rate gradually increased from the urban area of Tianjin to the suburbs and high subsidence zones were mainly distributed at the junction of the Wuqing, Xiqing and Beichen districts. In the past two years, the annual average subsidence rate in the high settlement area mostly exceeded −50 mm/year, which caused serious damage to local infrastructures. Besides, high-resolution remote sensing images combined with field investigations further verified the successful application of MT-InSAR technology in Tianjin’s subsidence monitoring. Effective ground subsidence control measures need to be taken as soon as possible to prevent the situation from getting worse.
Laboratory Study on the Performance of Asphalt Mixes Modified with a Novel Composite of Diatomite Powder and Lignin Fiber
Authors: Abdelsalam Moustafa , Yue Yanchao , Khater Ahmed , Luo Dong , Musanyufu Josephine , Qin Xiaoli
Published: August 2020

The performance and the fundamental weaknesses of asphalt mix under environmental temperature and water effects have made researchers try to modify the asphalt mix properties by using the proper additives. For this reason, this paper aims to improve the anti-cracking performance and water stability of asphalt pavement by adding a novel composite of diatomite and lignin fiber in asphalt mixes. Four types of asphalt mixes, including control asphalt mix (CAM), diatomite modified asphalt mix (DMAM), lignin fiber modified asphalt mix (LFMAM), and diatomite-lignin fiber composite modified asphalt mix (DLFMAM) were prepared in the laboratory. Low-temperature bending test, Marshall Immersion test, and freeze-thaw splitting test were employed to evaluate the performance of the asphalt mixes. Results reveal that the use of the lignin fiber in reinforced asphalt mixes combined with diatomite led to an enhancement in the asphalt pavement performance more than the other three types of mixes. Diatomite has an important influence on the water damage resistance of asphalt mix more than lignin fiber. On the other hand, diatomite has a small effect on the anti-cracking performance; meanwhile, lignin fiber showed a significant improvement in the cracking resistance of asphalt mixes. DLFMAM has the best traveling performances among all asphalt mixes. Thus, this work provides a good reference for the design of composite asphalt mixes.
A Rapid Method for Information Extraction from Borehole Log Images
Authors: Zhang Junqiang , Zhang Yi , Tian Yiping , Liu Gang , Xu Lirui , Hu Yong
Published: August 2020

Borehole logs are very important for geological analysis and application. Extracting structured information from borehole logs in the image format is the key to any analysis and application based on borehole data. The current method has defects in solving the beard phenomenon of the borehole log and the identification of special geological symbols. This paper proposes an automatic extraction method for borehole log information by combining the structural analysis based on the corner mark, as well as the structural understanding based on deep learning. The principles and key technologies of the method are described in detail. The performance of the method was tested by specific examples. This method is implemented on a geological information platform called QuantyView. The information extraction of 100 borehole logs with the same specification is used to verify the effectiveness of the proposed method. The results show that the method can not only effectively solve the inconsistency between the thickness and the description information in the borehole log but it can also address the low recognition efficiency of professional vocabulary, which can improve the extraction efficiency and accuracy of the borehole log information.
Experimental Investigation on Evaluation of Thermal Performance of Solar Heating System Using Al2O3 Nanofluid
Authors: Lee Youngho , Jeong Hyomin , Park Ji-Tae , Delgado Antonio , Kim Sedong
Published: August 2020

Over the years, solar collecting systems have gained interest in renewable energy. This study investigated improving the efficiency of the working fluid in thermal solar systems by using nanofluids with three concentrations of alumina, 0.1, 0.3, and 0.5 wt%. The UV-vis absorbance, electronic conductivity, and thermal transfer properties of the nanofluids were analyzed, and the thermal changes with exposure to solar radiation in an experimental collector system were measured by pyranometer. The electronic conductivity, thermal conductivity, and UV-vis absorbance increased with the alumina concentration. Moreover, the temperatures of the nanofluids increased more under solar irradiation than that of distilled water. This implies that the alumina nanofluids absorb solar energy more efficiently than water. The findings of this study suggest that the use of both alumina nanofluids and nanoparticles will improve the efficiency of thermal solar power systems.
Comparison of Optical Imaging Techniques to Quantitatively Assess the Perfusion of the Gastric Conduit during Oesophagectomy
Authors: Slooter Maxime D. , Jansen Sanne M. A. , Bloemen Paul R. , van den Elzen Richard M. , Wilk Leah S. , van Leeuwen Ton G. , van Berge Henegouwen Mark I. , de Bruin Daniel M. , Gisbertz Suzanne S.
Published: August 2020

In this study, four optical techniques—Optical Coherence Tomography, Sidestream Darkfield Microscopy, Laser Speckle Contrast Imaging, and Fluorescence Angiography (FA)—were compared on performing an intraoperative quantitative perfusion assessment of the gastric conduit during oesophagectomy. We hypothesised that the quantitative parameters show decreased perfusion towards the fundus in the gastric conduit and in patients with anastomotic leakage. In a prospective study in patients undergoing oesophagectomy with gastric conduit reconstruction, measurements were taken with all four optical techniques at four locations from the base towards the fundus in the gastric conduit (Loc1, Loc2, Loc3, Loc4). The primary outcome included 14 quantitative parameters and the anastomotic leakage rate. Imaging was performed in 22 patients during oesophagectomy. Ten out of 14 quantitative parameters significantly indicated a reduced perfusion towards the fundus of the gastric conduit. Anastomotic leakage occurred in 4/22 patients (18.4%). At Loc4, the FA quantitative values for “T1/2” and “mean slope” differed between patients with and without anastomotic leakage (p = 0.025 and p = 0.041, respectively). A quantitative perfusion assessment during oesophagectomy is feasible using optical imaging techniques, of which FA is the most promising for future research.
A Multi-Layer Perceptron Network for Perfusion Parameter Estimation in DCE-MRI Studies of the Healthy Kidney
Authors: Klepaczko Artur , Strzelecki Michał , Kociołek Marcin , Eikefjord Eli , Lundervold Arvid
Published: August 2020

Background: Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is an imaging technique which helps in visualizing and quantifying perfusion—one of the most important indicators of an organ’s state. This paper focuses on perfusion and filtration in the kidney, whose performance directly influences versatile functions of the body. In clinical practice, kidney function is assessed by measuring glomerular filtration rate (GFR). Estimating GFR based on DCE-MRI data requires the application of an organ-specific pharmacokinetic (PK) model. However, determination of the model parameters, and thus the characterization of GFR, is sensitive to determination of the arterial input function (AIF) and the initial choice of parameter values. Methods: This paper proposes a multi-layer perceptron network for PK model parameter determination, in order to overcome the limitations of the traditional model’s optimization techniques based on non-linear least-squares curve-fitting. As a reference method, we applied the trust-region reflective algorithm to numerically optimize the model. The effectiveness of the proposed approach was tested for 20 data sets, collected for 10 healthy volunteers whose image-derived GFR scores were compared with ground-truth blood test values. Results: The achieved mean difference between the image-derived and ground-truth GFR values was 2.35 mL/min/1.73 m2, which is comparable to the result obtained for the reference estimation method (−5.80 mL/min/1.73 m2). Conclusions: Neural networks are a feasible alternative to the least-squares curve-fitting algorithm, ensuring agreement with ground-truth measurements at a comparable level. The advantages of using a neural network are twofold. Firstly, it can estimate a GFR value without the need to determine the AIF for each individual patient. Secondly, a reliable estimate can be obtained, without the need to manually set up either the initial parameter values or the constraints thereof.
Bayesian Updating of Soil–Water Character Curve Parameters Based on the Monitor Data of a Large-Scale Landslide Model Experiment
Authors: Feng Chengxin , Tian Bin , Lu Xiaochun , Beer Michael , Broggi Matteo , Bi Sifeng , Xiong Bobo , He Teng
Published: August 2020

It is important to determine the soil–water characteristic curve (SWCC) for analyzing landslide seepage under varying hydrodynamic conditions. However, the SWCC exhibits high uncertainty due to the variability inherent in soil. To this end, a Bayesian updating framework based on the experimental data was developed to investigate the uncertainty of the SWCC parameters in this study. The objectives of this research were to quantify the uncertainty embedded within the SWCC and determine the critical factors affecting an unsaturated soil landslide under hydrodynamic conditions. For this purpose, a large-scale landslide experiment was conducted, and the monitored water content data were collected. Steady-state seepage analysis was carried out using the finite element method (FEM) to simulate the slope behavior during water level change. In the proposed framework, the parameters of the SWCC model were treated as random variables and parameter uncertainties were evaluated using the Bayesian approach based on the Markov chain Monte Carlo (MCMC) method. Observed data from large-scale landslide experiments were used to calculate the posterior information of SWCC parameters. Then, 95% confidence intervals for the model parameters of the SWCC were derived. The results show that the Bayesian updating method is feasible for the monitoring of data of large-scale landslide model experiments. The establishment of an artificial neural network (ANN) surrogate model in the Bayesian updating process can greatly improve the efficiency of Bayesian model updating.
Theranostic Nanoplatforms of Thiolated Reduced Graphene Oxide Nanosheets and Gold Nanoparticles
Authors: Tomasella Pascal , Sanfilippo Vanessa , Bonaccorso Carmela , Cucci Lorena Maria , Consiglio Giuseppe , Nicosia Angelo , Mineo Placido Giuseppe , Forte Giuseppe , Satriano Cristina
Published: August 2020

In this study, graphene oxide (GO) and reduced-thiolated GO (rGOSH) were used as 2D substrate to fabricate nanocomposites with nanoparticles of gold nanospheres (AuNS) or nanorods (AuNR), via in situ reduction of the metal salt precursor and seed-mediated growth processes. The plasmonic sensing capability of the gold-decorated nanosheets were scrutinized by UV-visible (UV-VIS) spectroscopy. Attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), thermogravimetric analyses (TGA), and atomic force microscopy (AFM) were performed in order to prove the actual reduction that occurred concomitantly with the thiolation of GO, the increase in the hydrophobic character as well as the size, and preferential gathering of the gold nanoparticles onto the nanosheet substrates, respectively. Moreover, the theoretical electronic and infrared absorption (UV-VIS and IR) spectra were calculated within a time-dependent approach of density functional theory (DFT). Eventually, in vitro cellular experiments on human neuroblastoma cells (SH-SY5Y line) were carried out in order to evaluate the nanotoxicity of the nanocomposites by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide tetrazolium reduction (MTT) colorimetric assay. Results pointed out the promising potential of these hybrids as plasmonic theranostic platforms with different hydrophilic or hydrophobic features as well as cytotoxic effects against cancer cells.
A Freeport Comes to Luxembourg, or, Why Those Wishing to Hide Assets Purchase Fine Art
Authors: Weeks Samuel
Published: August 2020

This article addresses how global art markets are becoming an outlet of choice for those wishing to hide assets. Recent efforts by the OECD and the U.S. Treasury have made it more difficult for people to avoid taxes by taking money “offshore”. These efforts, however, do not cover physical assets such as fine art. Citing data collected in Luxembourg—a jurisdiction angling to become a worldwide leader in “art finance”—I discuss the characteristics of this emerging system of opaque economic activity. The first of these is a “freeport”, a luxurious and securitized warehouse where investors can store, buy, and sell art tax free with minimal oversight. The second element points to the work of art-finance professionals, who issue loans using fine art as collateral and develop “art funds” linked to the market value of certain artworks. The final elements cover lax scrutiny by enforcement authorities as well as the secrecy techniques typically on offer in offshore centers. Combining these elements in jurisdictions such as Luxembourg can make mobile and secret the vast wealth stored in fine art. I end the article by asking whether artworks linked to freeports and opaque financial products have become the contemporary version of the numbered Swiss bank account or the suitcase full of cash.
Local Weather Types by Thermal Periods: Deepening the Knowledge about Lisbon’s Urban Climate
Authors: Reis Cláudia , Lopes António , Correia Ezequiel , Fragoso Marcelo
Published: August 2020

Urbanized hot spots incorporate a great diversity of microclimates dependent, among other factors, on local meteorological conditions. Until today, detailed analysis of the combination of climatic variables at local scale are very scarce in urban areas. Thus, there is an urgent need to produce a Local Weather Type (LWT) classification that allows to exhaustively distinguish different urban thermal patterns. In this study, hourly data from air temperature, wind speed and direction, accumulated precipitation, cloud cover and specific humidity (2009–2018) were integrated in a cluster analysis (K-means) in order to produce a LWT classification for Lisbon’s urban area. This dataset was divided by daytime and nighttime and thermal periods, which were generated considering the annual cycle of air temperatures. Therefore, eight LWT sets were generated. Results show that N and NW LWT are quite frequent throughout the year, with a moderate speed (daily average of 4–6 m/s). In contrast, the frequency of rainy LWT is considerably lower, especially in summer (below 10%). Moreover, during this season the moisture content of the air masses is higher, particularly at night. This methodology will allow deepening the knowledge about the multiple Urban Heat Island (UHI) patterns in Lisbon.