bluuebunny/crossref_metadata_2025 huggingface dataset:
Advances and Challenges in Aeromonas hydrophila Vaccine Development: Immunological Insights and Future Perspectives
Authors: Miryala Kavi R. , Swain Banikalyan
Published: February 2025

Aeromonas hydrophila presents a significant threat to global aquaculture due to its ability to infect freshwater and marine fish species, leading to substantial economic losses. Effective mitigation methods are essential to address these challenges. Vaccination has emerged as a promising strategy to reduce A. hydrophila infections; however, it faces several obstacles, including variability in immune responses, pathogen diversity, and environmental factors affecting vaccine efficacy. To enhance vaccine performance, researchers focus on adjuvants to boost immune responses and develop multivalent vaccines targeting multiple A. hydrophila strains. Tailoring vaccines to specific environmental conditions and optimizing vaccination schedules can further address the challenges posed by pathogen diversity and variable immune responses. This review provides an in-depth analysis of the immunological hurdles associated with A. hydrophila vaccine development. Current vaccine types—live attenuated, inactivated, subunit, recombinant, and DNA—exhibit diverse mechanisms for stimulating innate and adaptive immunity, with varying levels of success. Key focus areas include the potential of advanced adjuvants and nanoparticle delivery systems to overcome existing barriers. The review also highlights the importance of understanding host–pathogen interactions in guiding the development of more targeted and effective immune responses in fish. Complementary approaches, such as immunostimulants, probiotics, and plant-based extracts, are explored as adjuncts to vaccination in aquaculture health management. Despite notable progress, challenges remain in translating laboratory innovations into scalable, cost-effective solutions for aquaculture. Future directions emphasize the integration of advanced genomic and proteomic tools to identify novel antigen candidates and the need for industry-wide collaborations to standardize vaccine production and delivery. Addressing these challenges can unlock the potential of innovative vaccine technologies to safeguard fish health and promote sustainable aquaculture practices globally.
The Occurrence and Meta-Analysis of Investigations on Intestinal Parasitic Infections Among Captive Wild Mammals in Mainland China
Authors: Zhang Xueping , Zhou Hongyu , Ye Lina , Shi Jiayu , Zhang Huiling , Zhang Tangjie
Published: February 2025

This study investigated the infection rates of intestinal parasites in captive wild animals from 2000 to 2024 and analyzed the associated risk factors using a meta-analysis. We retrieved 29 studies, with a total of 8421 captive wild mammals, published between 2000 and 2024. We used the DerSimonian-Laird model and calculated infection rate estimates with the variance stabilizing double arcsine transformation. The results revealed that the overall prevalence of gastrointestinal parasitic infections in captive wild mammals in mainland China was found to be 53.9%. The highest infection rate was observed for nematodes at 45.1%. Seasonal subgroup analysis revealed the highest incidence in summer at 61.8% and 61.6% in winter. In the class order Mammalia, the highest infection rate was found in the Primates at 66.5% and similarly high values were determined in several other orders like Artiodactyla (59%), Rodentia (57.1%), Carnivora (53.3%) and extremely low in Proboscidea (19.9%). The highest overall infection rate was recorded in summer. The infection rate of gastrointestinal parasites in captive wild mammals in mainland China is notably high. Additionally, parasitic infection rates in captive animals were found to be lower in economically developed regions of mainland China.
Design and Test of a Cavitation Water Jet Net Box Cleaning Device Based on Ansys Fluent
Authors: Xiong Yuke , Xue Qingsong , Li Kuo , Bao Lei , Fu Zhixuan , Liu Zibo , Zhang Hanbing
Published: February 2025

This study addresses the issue of biofouling on marine aquaculture cages, where organisms like algae and purple mussels negatively impact both the safety of the aquaculture environment and the integrity of the cages. To solve this problem, the paper introduces a cage cleaning device based on the cavitation jet principle. Using finite volume simulation software, the cavitation process of the device’s nozzle was modeled, with the gas-phase volume fraction used as the evaluation metric. Key experimental factors, such as the second section throat contraction angle, second section throat radius, and end diffusion angle, were analyzed through single-factor and quadratic regression orthogonal experiments to assess their effect on the cavitation performance. The optimal combination of nozzle parameters was determined to be a second section throat contraction angle of 41.047°, a second section throat radius of 0.834 mm, and an end diffusion angle of 35.495°. Under these conditions, the gas-phase volume fraction reached 0.941, indicating optimal cavitation performance. To validate these findings and further optimize the nozzle’s operational parameters, a nozzle cavitation test bench was constructed. Test results demonstrated that when the target distance was set at 15 mm and the angle at 20°, the surface roughness and maximum surface depth of the target were 6.215 μm and 22.030 μm, respectively, with the nozzle exhibiting the best cavitation effect at these settings. This nozzle design meets the requirements for efficient mesh cleaning, and the research provides valuable insights for future development and optimization of cleaning devices for aquaculture net cages.
Determination of the Occurrence of Trihalomethanes in the Drinking Water Supply of the City of Cuenca, Ecuador
Authors: Hernández Bolívar , Duque-Sarango Paola , Tonón María Dolores , Abril-González Mónica , Pinos-Vélez Verónica , García-Sánchez Cristian R. , Rodríguez Manuel J.
Published: February 2025

Water chlorination, fundamental for its microbiological safety, generates by-products, such as trihalomethanes (THMs), potentially associated with carcinogenic and reproductive risks. This study determined the levels of chloroform (CHCl3) in drinking water in Cuenca, Ecuador, a topic that has been little explored in the region. During five months, water samples were collected from three water treatment systems (Cebollar, Tixan, and Sustag), and in situ measurements of physicochemical parameters such as free chlorine, pH, temperature, electrical conductivity, and turbidity were performed in the storage and distribution area. The determination of CHCl3 was performed following the Hach protocol. For data analysis, the Kruskal–Wallis test was employed, followed by Dunn’s post hoc method and Spearman’s correlation coefficient. The results revealed a progressive decrease in free residual chlorine throughout the distribution systems. CHCl3 concentrations ranged from 11.75 µg/L to 21.88 µg/L, remaining below the Ecuadorian regulatory limit of 300 µg/L. There was no consistent correlation between CHCl3 and physicochemical parameters. These findings align with previous research, suggesting that the variability in CHCl3 formation is associated with different water treatment conditions and environmental variables. This study highlights the importance of monitoring disinfection processes to minimize THMs and other DBPs, ensure public health, and contribute to sustainable drinking water management in Ecuador.
Demagnetization Fault Diagnosis for PMSM Drive System with Dual Extended Kalman Filter
Authors: Wang Jiahan , Li Chen , Zhou Zhanqing
Published: February 2025

Aiming at the irreversible demagnetization of permanent magnet synchronous motors (PMSMs) under extreme working conditions, a fault diagnosis method for permanent magnet demagnetization based on multi-parameter estimation is proposed in this paper. This scheme aims to provide technical support for enhancing the safety and reliability of permanent magnet motor drive systems. In the proposed scheme, multiple operating states of the motor are acquired by injecting sinusoidal current signals into the d-axis, ensuring that the parameter estimation equation satisfies the full rank condition. Furthermore, the accurate dq-axis inductance parameters are obtained based on a recursive least square method. Subsequently, a dual extended Kalman filter is employed to acquire real-time permanent magnet flux linkage data of PMSMs, and the estimation data between the two algorithms are transferred to each other to eliminate the bias of permanent magnet flux estimation caused by a parameter mismatch. Finally, accurate evaluation of the remanence level of the rotor permanent magnet and demagnetization fault diagnosis can be achieved based on the obtained permanent magnet flux linkage parameters. The experimental results show that the relative estimation errors of the dq-axis inductance and permanent magnet flux linkage are within 5%, which can realize the effective diagnosis of demagnetization fault and high-precision condition monitoring of a permanent magnet health.
O medo do crime
Authors: Rolim Marcos , Hermann Daiana , Koppitke Alberto L.W.
Published: February 2025

O artigo é um estudo comparativo sobre o fenômeno do “medo do crime” em duas cidades gaúchas, Porto Alegre e Santa Cruz do Sul, a partir dos dados colhidos por duas pesquisas de vitimização. Na revisão bibliográfica, examinamos as cinco revisões sistemáticas sobre medo do crime melhor ranqueadas segundo a bibliométrica do software Publish or Perish (PoP), publicados em língua inglesa, na plataforma Google Scholar, em um período de 10 anos (2012-2022). Com os mesmos critérios, revisamos os 10 estudos realizados no Brasil sobre o medo do crime mais bem situados no ranking do PoP, publicados em português no mesmo lapso temporal. Na comparação entre as duas cidades, encontramos níveis muito distintos de medo do crime, sendo o fenômeno muito mais expressivo em Porto Alegre. A distribuição do medo em ambas as cidades, entretanto, não se verifica de forma homogênea, havendo diferenças estatisticamente significativas para as variáveis de gênero, raça e renda. Em Santa Cruz do Sul, encontramos uma concentração do medo também significativa segundo a orientação sexual, atingindo mais amplamente homossexuais e bissexuais.
Historical memories on slavery in southern Somalia and Cabo Delgado, Mozambique
Authors: Declich Francesca
Published: February 2025

Living memories of past movements and migrations in and out of the Querimbas Islands, especially Ibo Island, are apt to present some surprises. When talking about slavery, some elders’ shared memories sometimes seem to be defensive, serving to justify the practice of slavery rather than decrying it. This may be ascribed to several factors. External observers often look at dependency interrelations in poor areas in ways that do not coincide with the views held by local people and there may be relevant historical reasons to account for the different perceptions. The reasons which lie behind the viewpoint held by some Ibo islanders would seem to be related to past events and conflicts that occurred many decades after slavery was abolished. This paper will explore some such reasons by inquiring into the ways people were recruited as forced laborers and looking into the policies that facilitated the lives of servants as opposed to people with autonomous occupations who could be coerced into forced laborer.
Supply of mineral substances to the adult population of the Western Siberia region
Authors: Brusentsova A. V. , Turchaninov D. V. , Shirinsky V. A. , Vilms E. A. , Yunatskaya T. A.
Published: February 2025

Aim. Hygienic assessment of mineral deficiencies among the adult population of Western Siberia.

   Materials and methods. The supply of minerals to the adult population of the Omsk region was assessed in a cross-sectional descriptive observational study based on the content of 24 elements in human hair in a random quota sample that included 333 people (151 men and 182 women).

   Results. In 69.7 ± 2.5 % of the adult population of the Omsk region, disturbances in the supply of mineral substances were noted. Among the most common deficiencies were zinc (32.4 ± 2.6 %), selenium (29.7 ± 2.5 %), copper (26.8 ± 2.4 %), magnesium (26.2 ± 2.4 %), iron (23.9 ± 2.3 %), silicon (16.8 ± 2.1 %), calcium (15.9 ± 2.0 %), potassium (15.9 ± 2.0 %), and molybdenum (11.4 ± 1.7 %). An increased content of toxic and potentially toxic mineral substances in the body was noted for such substances as aluminum (32.8 ± 2.6 %), cadmium (31.2 ± 2.5 %), and lead (10.1 ± 2.5 %). The elemental status in men and women, as well as in the age groups of 18–29 years, 30–44 years, 45–64 years, 65 and more years was determined. The frequency of mineral deficiencies increased with age for such elements as magnesium, iron, and selenium.

   Conclusion. In comparison with 2007–2010, a tendency towards a decrease in the frequency of mineral deficiency in the adult population of the region was observed. In 69.7 ± 2.5 % of the adult population of the Omsk region, disturbances in the supply of mineral substances were noted, with their frequency increasing with age and being more common in men.
Spectrum of secondary radiation from the hydroxyapatite-wollastonite marker for pre-irradiation marking
Authors: Pasechnik A. A. , Apanasevich V. I. , Papynov E. K. , Shichalin O. O. , Argishev O. A. , Stegniy K. V. , Nevozhay V. I. , Kostiv E. P. , Temchenko V. V. , Borisenko A. V. , Pankratov I. V.
Published: February 2025

Objective. To determine the potential for generating secondary radiation on a hydroxyapatite-wollastonite graft, which has the potential to be used as a marker for postoperative pre-irradiation marking.

   Materials and methods. During the simulation of a radiotherapy session, the spectrum of secondary radiation generated on the hydroxyapatite-wollastonite graft and polyacrylamide was studied. Polyacrylamide, composed of basic chemical elements similar to those in human soft tissues, was used as an equivalent. Hydroxyapatite-wollastonite was obtained by plasma-reactive sintering of Ca3(Si3O9) powder mixed with reactive components (CaO and CaHPO4HAP). The simulation of radiotherapy was conducted using a TrueBeam Linear Accelerator, developed by Varian Medical Systems, utilizing photon energy of 6 mega-electron volts (MeV) with a portable lead block shield and an aperture of 10 mm in diameter for irradiation. An SKS-50M gamma spectrometer with a high-purity germanium detector was used to record the photon distribution. Instrument readings were summarized in increments of 50 kilo-electron volts (keV) within the range of 0 to 2650 keV and presented graphically. Three measurements were taken in each range, after which the arithmetic mean and mean deviation were calculated. The significance of differences between means was determined using Student's t-test.

   Results. The secondary radiation from the studied samples in the range of 51–100 keV showed minor differences: hydroxyapatite-wollastonite produced 23.18 ± 2.57 pulses/second compared to polyacrylamide at 21.57 ± 2.37 pulses/second, while at energies of 101–150 keV, hydroxyapatite-wollastonite yielded 21.18 ± 2.51 pulses/second versus polyacrylamide at 22.9 ± 2.41 pulses/second. However, these differences were not statistically significant.

   Conclusion. The graft of hydroxyapatite-wollastonite micro-particles is considered to be a promising material for precise postoperative/pre-irradiation marking during treatment planning and does not require recalculation of radiation dose.
Valproic acid and celecoxib enhance the effect of temozolomide on glioblastoma cells
Authors: Pak O. I. , Kosianova A. A. , Zaitsev S. V. , Bryukhovetskiy I. S.
Published: February 2025

Objective. To evaluate the survival of patients with recurrent glioblastoma receiving valproic acid and to study its impact in combination with temozolomide and celecoxib on tumor cells.

   Materials and methods. A retrospective analysis was conducted on data from patients diagnosed with glioblastoma (ICD-10 – C71) who received valproic acid as part of their comprehensive treatment and were reoperated on with recurrent glioblastoma. Tumor cells of the C6, U87 and T98G lines were used for the experimental study. Glioblastoma modeling was performed using Wistar rats. The study was approved by the ethics committee.

   Results. The median overall survival of patients with glioblastoma receiving valproic acid accounted for 22 months, compared to 13 months for patients not receiving valproic acid. In in vitro experiments, the half-maximal inhibitory concentration (IC50) of temozolomide for various tumor cell lines ranged from 435.3 to 844 μM; the IC50 of valproic acid for U87MG, T98G, and C6 cell lines comprised 1510, 3900, and 3600 μM, respectively; the IC50 of celecoxib for these tumor cell lines amounted to 30.1, 41.07, and 48.4 μM, respectively. Valproic acid significantly enhanced the antiglioma effect of temozolomide on U87 cell lines; the highest sensitivity to the action of celecoxib in combination with temozolomide was observed in C6 and T98G cell lines. The combination of valproic acid with celecoxib enhanced the antiglioma action of temozolomide both in vitro and in vivo, which was accompanied by a reduction in tumor volume (p < 0.05) and increased survival of experimental animals.

   Conclusion. The high antiglioma potential of the combination of valproic acid and celecoxib with temozolomide opens up prospects for optimizing existing treatment approaches for recurrent glioblastoma, thereby highlighting the need for further research. Valproic acid and celecoxib enhance the effects of temozolomide on glioblastoma cells.
Echoes of Past: The Joyful Dance of Nostalgia in Tales around the World
Authors: Margaret Karunya R.
Published: February 2025

Nostalgia is a powerful memory of reflective affection and sometimes a soap-operatic or longing for a time in the past. Both pleasure and wretchedness are the two sides of nostalgia. The individual reminisces the past moments, experiences, locations and relationships. These influential emotions have been playing a vital role in world literature and functions as the prominent theme which relates the readers experience with the characters and events in the literature. “Nostalgia, unlike screen memory, does not relate to a specific memory, but rather to an emotional state” Alan R. Hirsh defines psychologically.The stories of different cultures and nations frequently apply the theme of nostalgia to replicate on individual and collective identities by emphasizing the impression of the recollection on cultural inheritance. Most writers employ nostalgia to propose cultural shifts, emotional reactions, and generate nuance to character development and explore social changes. Eventually, nostalgia improves story telling by encouraging links between the past and present, enabling readers to involve with their own pasts and recollections. Nostalgia predominantly shapes the identities, purposes, and emotional landscapes of characters in world literature. In the lens of nostalgia, literary art repeatedly mirrors the cultural and historical contexts to analyze the social and cultural transforms or expose the desire for a perceived golden age. The readers could easily connect their own experiences with this interchange between reminiscence and individuality. The writers employ nostalgia as an influential key theme that echoes through various cultures and narratives.
Cultural Representation of Fatness: Exploring the Cultural Narratives in India
Authors: Dhivyaa R. , Geetha S.
Published: February 2025

Cultural Identity is part of an individual’s self-conception and it is mostly influenced by various factors like region, religion, and belief system that one follows. One’s cultural identity holds an impact on how one perceives the world they live in. The representation of fatness is also highly dominated by cultural perceptions. This study aims to look at the locus of fatness in society based on cultural representations in India. Fatness in Indian culture is understood in various means of social perceptions depending on religion, caste, beliefs, health and beauty standards. Fatness is discursive and has been portrayed under various lenses like traditional, colonial, spiritual, mythical, and health consciousness. Fat body types were considered as a symbol of negativity in myths. Most of the demons are given a fat body. Fatness is related to riches, luxury in tradition where people see Lord Kubera, god of wealth in Hindu religion, as a fat figure. In the colonial period, fatness was related to laziness and most of the working class people were thin. Medically fatness is seen as a disease. Post-Independence, fatness is related to ugliness. Media treats fat people as aliens. Fat characters in movies are used as comic relief and it reduces the value of fat people. Fat people in the modern era are fighting for proper recognition. Social media has made it harder for fat individuals to survive. The online platform judges individuals without proper understanding and provides space for prejudices and stereotypes. This study aims at proper understanding of cultural influences of representation of fatness in India. Also the paper aims at examining the intersection of fatness with categories such as class, caste, and gender. The paper calls for a more nuanced understanding of fatness reevaluating the Indian cultural narratives.
From Venice to Uttar Pradesh: Adapting Othello to Omkara
Authors: John Sona
Published: February 2025

This paper explores the adaptation of Shakespeare’s Othello into Vishal Bhardwaj’s Omkara through the lens of adaptation theory, focusing on the shift from the Venetian setting to rural Uttar Pradesh. Omkara reimagines the Shakespearean tragedy within the socio-political framework of India, translating themes of jealousy, power, and betrayal into the context of caste and regional power dynamics. By analysing how Omkara maintains the core narrative of Othello while transforming its characters, setting, and socio-cultural references, this paper investigates the tension between fidelity and creative freedom in adaptation. Using Robert Stam’s theory of adaptation discussed in his work Literature and Film: A Guide to the Theory and Practice of Film Adaptation, the study addresses how Bhardwaj’s film retains Shakespeare’s tragic essence while making it accessible and relevant to an Indian audience. The paper also examines how Omkara reconfigures the representation of gender and power, recontextualizing Desdemona/Dolly and Iago/Langda within an Indian patriarchal structure. Through this comparative analysis, the paper highlights the fluidity of storytelling across cultures and the significance of localizing universal narratives to reflect contemporary societal concerns. An in-depth analysis of both the play and the film depicts how each work of adaptation is free from its source text as described by Robert Stam in his theory of adaptation, and how an adapted work would be situated in its contemporary situation where the societal conditions, norms, and gender roles would vary with the changing time periods and spaces. A comparison between Shakespeare’s Othello and Vishal Bhardwaj’s Omkara shows how the issue of fidelity is totally out of question and how a piece of art transcends the temporal and spatial boundaries.
Projection of Post Colonialism and Post Modernism in Salman Rushdie’s Midnight’s Children
Authors: Ilakkiya M.
Published: February 2025

Post Colonialism, Post Modernism, Magical Realism, Mythology, Deconstruction and Deformation are some of the theories that are been frequently reflected in our Indian Literature. Salman Rushdie has brilliantly implied these intellectual theories in his novel Midnight’s Children through his own tactics and ideas, which won him the Booker Prize Award in 1981. The implication of such theories in it was made possible with its dealing of the India’s past and binding Indian culture of past to the contemporary multicultural interface. The rare combination of all these combination of theories makes this novel a great post modernistic work. This Paper deals directly with the India’s partition from almost an Indian perspective. These qualities of this novel make it a literature of privilege and protest. It remains as an epitome, imposing Indian values, and economic pressure, cultural and religious predicaments that prevailed during and after the colonialism.
Empowered Women and Feminism in the Novels of Indu Sundaresan
Authors: Qurieshy Shabana , Tiwari Shubha
Published: February 2025

This research paper investigates the nuanced portrayal of empowered women and feminist ideologies in the novels of Indu Sundaresan. Through a meticulous analysis of works such as The Twentieth Wife and The Feast of Roses, the study examines how Sundaresan reconstructs historical narratives to spotlight female agency and resistance against patriarchal norms. Her storytelling vividly captures the complex interplay of gender, power, and societal constraints within historical contexts. The research highlights recurring themes such as autonomy, solidarity among women, and the intersection of gender and politics, which underpin Sundaresan’s feminist ethos. By presenting women who navigate and often subvert oppressive structures, her works challenge traditional portrayals of women in historical fiction. The paper further explores the development of her protagonists, who emerge as multidimensional figures embodying both strengths and vulnerabilities, thereby making them relatable and inspiring. Ultimately, this study underscores how Sundaresan’s novels not only reclaim the voices of marginalized women but also contribute to contemporary feminist discourse by inspiring a re-evaluation of historical gender dynamics.
Navigating Intercultural Competence and Language Development in the Social Media Age
Authors: Harishma H.
Published: February 2025

Social media connects individuals and communities across the globe. Social media platforms like Instagram, X, Facebook, Threads enables users to share ideas and traditions in real time and serves as powerful tools for advocacy and change. This constant exchange fosters cultural awareness and global interconnectedness. Social media is also a dynamic tool for language acquisition by offering exposure to multilingual content and enabling interactive communication in real world context. It also presents challenges such as the risk of culturalmis representation, reinforcement of stereotypes and the use of informal language. Like a coin which has two sides, social media offers opportunities and challenges, questioning the notion of cultural understanding and acquisition of languages. This paper explores both the opportunities and challenges and also emphasizes how culture and language is being misrepresented.
Evaluating the outcomes of manual small incision cataract surgery for advanced cataract in New Zealand
Authors: Oh Jee Ah , Murray Neil , Murray Tania , McKelvie James
Published: February 2025

Purpose: To evaluate patient demographics, visual and keratometric outcomes, and complications of manual small incision cataract surgery (mSICS) to treat advanced cataract in New Zealand.
Study design: A total of 289 eyes undergoing consecutive mSICS by a single surgeon in Rotorua Eye Clinic in New Zealand between January 2011 and October 2015 were prospectively included.
Methods: Patient demographics, visual and keratometric outcomes including corrected distance visual acuity (CDVA) and vector analysis of surgically induced astigmatism (SIA), were analysed. Predicted and observed risk-adjusted surgical complications were compared.
Results: The mean patient age at time of surgery was 73.6 years. New Zealand European constituted the single largest ethnic group at 51.6% (n = 149). Māori were the second largest ethnic group at 35.6% (n = 103). Overall, 88.2% (n = 255) of patients achieved postoperative CDVA of 6/12 or better at 4 weeks following surgery. Themean postoperative logMAR CDVA was 0.17 ± 0.37 SD (6/9 + 2 Snellen equivalent). The mean SIA magnitude was 0.99 D (SD = 0.76 D). Preoperative risk of posterior capsule rupture was 5.2% but no cases were observed. Iris prolapse was noted in 1 case (0.4%) and endophthalmitis in 2 cases (0.7%).
Conclusions: This is the largest study of mSICS in a developed country to date. mSICS is a safe and effective technique for advanced cataract extraction in a developed country with excellent visual outcomes. The incidence of posterior capsular rupture was below the predicted rate; however, endophthalmitis was higher than expected for a cohort of this size.
¿Es un positivismo jurídico pluralista posible?
Authors: Tornel Calderón Marcos García
Published: February 2025

Es frecuente que las posiciones teóricas que defienden el pluralismo jurídico tomen como punto de partida una crítica al positivismo jurídico, suponiendo una situación antitética entre ambas posturas. En este documento se hipotetiza que es posible –e incluso necesario– construir un modelo de iuspositivismo no monista que, a través de la autonomía indígena originario campesina y la jurisdicción indígena originario campesina, compatibilice la definición tradicional de ordenamiento jurídico con un contexto de reconocimiento constitucional de formas de legalidad no estatales. Se propone tomar como punto de partida la noción de que existen diversas aristas del iuspositivismo y analizar tres posturas teóricas representativas del positivismo jurídico –Kelsen, Hart y Raz– para identificar si el centralismo (un elemento usualmente considerado determinante en las formas predominantes de positivismo jurídico) es realmente esencial para éste. Finamente, se proponen algunas consideraciones básicas que debería tener una postura positivista y pluralista del derecho como un acercamiento a la forma de concebirlo, estudiarlo y aplicarlo.
Game-Based Digital Math Intervention's Effect on Math Anxiety and Its Variation across Classrooms
Authors: Egorova Alena
Published: February 2025

Digital math learning interventions, especially game-based interventions, have the potential to reduce math anxiety in students; however, evidence of their impact is mixed. We examined the effects of a game-based and a non-game-based digital math learning intervention on 677 seventh-grade students’ math anxiety and how these effects vary across classrooms. Although math anxiety did not decrease as a result of the interventions, our analysis demonstrated large variation of the intervention type effect between classrooms, indicating some classroom characteristics might significantly impact the way interventions influenced math anxiety. Moreover, a small but significant cross-level interaction between intervention type and classroom average math anxiety was detected, where students in classrooms with higher levels of math anxiety demonstrated a larger decrease in math anxiety after solving problems in a non-gamed based vs. gamed-based intervention. Potential explanations and implications of findings are discussed.
Como vislumbrar os lugares no/do Plantationoceno?
Authors: Bernardes de Souza Júnior Carlos Roberto
Published: February 2025

Beyond the conceptual generalizations of the Anthropocene, the idea of the Plantationocene aims to put the topological character of the environmental and colonial fracture. Thus, the present essay seeks to problematize how the effects of the Plantationocene potentially spread out in worlds and places, generating situations of vulnerability. To do so, it employs a bibliographical revision articulated to a theoretical reflection that associates discussions of cosmopolitics, science and technology studies, decoloniality and environmental philosophy with the references of Cultural Geography. It identifies that the Plantationoceno might also be understood as a geographical condition that multiply situations of place’s precarity and vulnerability. This process transforms placeness into ends of the worlds that affect human and non-human existential dynamics, situating both in situations of survival amidst topocidic threats.
Conflitos e contradições no espaço vivido em torno dos usos e normatizações em uma cidade patrimonializada:
Authors: Fraga Livia , Baumgartner Wendel Henrique
Published: February 2025

The analysis in this article allows us to understand the production of urban space (Lefebvre, 1974) in Cachoeira through out the interconnection between the conceived, perceived and lived spaces. In this city, where there is a conception of space, based in the overrule of the historical heritage in the conceived space dimension, associated with the norms of a protected material place. However, the results of our research show that this conception in the lived space is just a fragment of the patrimonial and touristic determinations since the values and use practices in Cachoeira tension and oppose the conceived space.
Research on Innovative Reform of General Education in "Introduction to the Analects" Course
Authors:   College of Literature and Media, Zhaoqing University, Zhaoqing 526061, China, Li Yachen
Published: February 2025

Teaching a course “The Introduction to the Analects” is based on the “Analects of Confucius” to explore and discuss the relationship between traditional Chinese education (Guoxue) and modern analects. In the course, the theory and basic framework of Confucian thought are taught. The essential content of the Analects is selected according to five themes of “Moral Cultivation”, “Education”, “Filial Piety”, “Benevolence and Virtue”, and “Governance”. Through discussion with students and speculative and practical teaching methods, educational strategies are formulated for students by incorporating allusions and fables and conducting discussions and reflections. Guidance to students is provided for them to integrate what they have learned into their daily lives. Detailed exploration is conducted from two aspects: “teaching methodology” and “teaching process”. In this research, the teaching materials and methods of the “Introduction to the Analects” were developed to provide students with correct guidance on moral concepts to reflect the lessons from the “Analects of Confucius” on themselves and find answers to life and behavior. Then, the challenges and difficulties faced by the decline of moral education in today’s society can be addressed by integrating traditional Confucian thinking into current moral education and implementing the “Application of Tongjing”.
Estrategias Cogninterpretativas en el desarrollo del pensamiento crítico en los estudiantes de la escuela de posgrado de una universidad pública de Lima
Authors: Arbieto Cortez Cecilia
Published: February 2025

The objective of this research was to develop a pedagogical proposal to foster critical thinking in third-cycle master’s students specializing in University Teaching at a public university in Lima. This study emerged from the need to promote activities that strengthen competencies associated with this type of thinking among students. The methodology was framed within the socio-critical paradigm, with a projective approach and holistic design, as the changes sought to encourage reflection and action among the 108 participants, selected through probabilistic sampling. During the diagnostic phase, a survey validated by experts was applied, consisting of 42 items distributed across 10 dimensions, aimed at assessing competencies related to critical thinking. The results revealed that students possess some competencies that support critical thinking, such as skills for critical reading and content interpretation. Despite these strengths, areas for improvement and opportunities to enhance participants’ cognitive skills were identified. It was concluded that designing an intervention strategy, such as the proposed one, can enhance existing competencies and develop new ones, promoting autonomy, critical thinking, and reflection on the information and knowledge they access.
Transformasi Dakwah dalam Meningkatkan Efektivitas Penanganan Stunting di Kabupaten Langkat
Authors: Amril Amril , Kholil Syukur
Published: February 2025

Purpose: This study aimed to explore how religious dakwah can raise community awareness and participation in stunting prevention efforts in Langkat Regency, where the prevalence of stunting is higher than the national average. This study introduced a novel approach by integrating religious dakwah with health communication to address stunting in rural areas.
Methodology: A qualitative case study approach was used in the Langkat Regency, Indonesia. Newcomb’s Symmetrical Communication Theory was applied to create balanced two-way communication among religious leaders, healthcare workers, and the community. Data were collected through in-depth interviews with religious leaders, healthcare workers, and mothers of young children to capture their experiences and perspectives.
Results: The findings demonstrated that combining transformative dakwah with health education effectively bridges communication gaps, increases community involvement, and enhances awareness of child nutrition. This integrated approach was found to be particularly effective in encouraging preventive behaviors within the community.
Limitations: This study is limited to the specific cultural and geographical context of the Langkat Regency, which may affect the generalizability of the results to other regions with different cultural settings.
Contribution: This study contributes to the field of health communication and community health by demonstrating the potential of integrating religious dakwah with health programs to prevent stunting. It is especially valuable for stakeholders in the health and religious sectors to seek culturally sensitive approaches to public health issues.
THE ROLE OF REGIONAL GOVERNMENT IN SETTLEMENT OF AGRARIAN CONFLICT
Authors: Arisandi Fahmi , Pareke J.T.
Published: February 2025

The Kutei Lubuk Kembang indigenous community, Rejang Lebong Regency, is one example of the many conflicts faced by the community as described in the section above in the forestry sector. In 2016, suddenly the Kutei Lubuk Kembang traditional community area with plantation and agricultural functions which had been cultivated for generations by community members covering an area of 125.4 hectares was designated by the Ministry of Environment and Forestry as a state forest area with its function as production forest limited. The main problem of this research is what is the role of local government in resolving agrarian conflicts (Case Study of Conflict in the Traditional Area of the Kutei Lubuk Kembang Indigenous Community in a state forest area). This research is an academic effort that aims to analyze and describe the role of local government in resolving agrarian conflicts, especially in Rejang Lebong Regency, Bengkulu Province. this research uses a sociolegal approach. Sociolegal studies are interdisciplinary studies that are a hybrid of major studies of legal science and legal sciences from a societal perspective that were born previously. The need to explain legal issues in a more theoretically meaningful way fuels this study. Meanwhile, practically, this study is also needed to explain the operation of law in people's lives. This research concludes that, Regional Government has an important role in resolving agrarian conflicts in forest areas, Issuance of Rejang Lebong Regency Regional Regulation No. 5 of 2018 concerning Recognition and Protection of Customary Law Communities in Rejang Lebong Regency and Regent's Decree No. No. 180.65.I of 2020 concerning Recognition and Protection of Kutei Lubuk Kembang as a Customary Law Community Unit in Rejang Lebong Regency, is an effort by the Regional Government of Rejang Lebong Regency to resolve agrarian conflicts, especially in the state forest area in Lubuk Kembang Village.
CRIMINOLOGICAL REVIEW OF THE PERPETRATORS OF THE CRIMINAL ACT OF FALSE TESTIMONY
Authors: Andika Frengki , Sastra Putra Hendi , Sarianti Betra , Tri Mayasari Riri
Published: February 2025

The science of law in general and its practice often raises problems relating to the existence of the rule of law and the effectiveness of the rule of law by highlighting the effectiveness of the law to be achieved. This reason prompted the researcher to compile the final project with the title: "Review of Criminology of Perpetrators of False Statements (Case Studies at the Rejang Lebong Resort Police)." at the Rejang Lebong Resort Police). 2) What are the factors causing the perpetrators of the crime of committing false statements (a case study at the Rejang Lebong Resort Police). The approach used in this study is the type of research used by researchers is empirical juridical research that is descriptive in nature. Legal research is descriptive in nature, which is research that describes the characteristics of individuals, circumstances, symptoms or groups. Data obtained directly from the results of field studies by conducting interviews with sources and legal materials that researchers obtain. Based on the results of the research and discussion of the issues discussed, the following conclusions can be drawn: 1) Members of the Padang Ulak Tanding Police have been examined and questioned in connection with the criminal act that committed, ordered to commit, and participated in the above false statement. oath as referred to in Article 242 Paragraph (1) of the Criminal Code in conjunction with Article 55 Paragraph (1) to 1 of the Criminal Code. 2) Economic factors The suspect received money from the result of a false statement amounting to Rp. 25,000,000 (twenty-five million rupiah). Environmental factors where the environment around a person can cause that person to meet different people, so it is association that will determine whether a human behaves well or badly.
LAW AND POLICY RECOGNITION AND PROTECTION OF INDIGENOUS PEOPLES RIGHT IN INDONESIA
Authors: Arisandi Fahmi , Pareke J.T.
Published: February 2025

This article will describe Indigenous People’s as legal subjects whose existence has been recognized by the constitution of the Republic of Indonesia in Article 18 B paragraph (2) of the 1945 Constitution, which clearly states that "The State recognizes and respects the units of Indigenous Law Communities and their rights." traditional as long as it is still alive and in accordance with the development of society and the principles of the Unitary State of the Republic of Indonesia, which are regulated in the Law"; Apart from that, recognition and protection for Indigenous People’s and their traditional rights should be realized. This is also clearly regulated in Article 28 I of the 1945 Constitution. Even though the existence of culture has always been shown, Indigenous Peoples are still struggling to pass legislation which specifically regulates the recognition and protection of the rights of indigenous peoples through the draft act of indigenous people’s right have not yet fulfilled in Indonesia.
The Perspective of Islamic law on the System of Borrowing Money with Land as Collateral (sande) in South Bengkulu Regency
Authors: Akhmad Akhmad , Harsono Poewarjo Juli
Published: February 2025

This study examines the practice of borrowing money with land as collateral (Sande) in South Bengkulu Regency from the perspective of Islamic law. The practice, rooted in local tradition, offers a quick and accessible means for individuals to address urgent financial needs without engaging with conventional financial institutions. The Sande system is characterized by mutual agreement between the pledgor and the pledgee, involving land as a pledged asset for the loan. While generally aligned with Islamic legal principles, such as honesty, transparency, and fairness in transactions, some practices raise concerns, particularly when the pledgee’s benefits exceed the value of the collateral, challenging the ethical boundaries of the agreement.
Tachycardia-Bradycardia Syndrome: Case Report and Literature Review
Authors: Lamtai Mouad , Kriouel Asmae , Benssied Asmae , Elhmaidi Douaa , Khatouf Afaf , Maliki Kaoutar , Ezzahraoui Oumaima , Hilal Safae , Fellat Ibtissam , Cherti Mohamed
Published: February 2025

Sinus node dysfunction or sick sinus syndrome refers to a group of conditions characterized by abnormal cardiac pacing, leading to various cardiac bradyarrhythmia, tachyarrhythmia or bradycardia alternating with tachycardia. These arrhythmias can cause palpitations and reduced tissue perfusion, resulting in symptoms such as fatigue, lightheadedness, and sometimes syncope. Herein we report a case of sinus node dysfunction that initially manifested as supraventricular tachycardia but was later diagnosed as tachycardia-bradycardia syndrome.
Role of Plasminogen Activator Inhibitor-1 (PAI-1) in Oral Squamous Cell Carcinoma
Authors: Rahman Gehan Abdel Naser Abdel , Younis Rania Hassan
Published: February 2025

Background: Squamous cell carcinoma (SCC) accounts for around 90% of malignant neoplasms of the oral cavity and is a serious public health problem. The 5-year survival rate of oral and pharyngeal SCC is estimated to be around 63%, despite advances in the treatments. Particularly SCCs affecting the oral and mobile portion of the tongue (OTSCCs) show a high pitfall of recurrence and lymph node metastasis. Within this context, biomarker studies are essential for better understanding of the pathogenesis of the disease, better prognostication and better therapeutic strategies. Proteins of the plasminogen activator system (PAS) have been correlated with the prognosis and clinical behavior of several types of cancer, such as breast, lung, esophageal, gastric, and oral cancers. The PAS consists of a set of molecules that integrates extracellular matrix (ECM) changes. Within this system, conversion of the pro-enzyme plasminogen into plasmin occurs, cleavage of ECM, and stimulation of other proteolytic enzymes as matrix metalloproteinases (MMPs). In malignant neoplasms, the conversion of plasminogen to plasmin is intermediated principally by urokinase-type plasminogen activator (uPA). The formation of plasmin is blocked basically by plasminogen activator inhibitor-1 (PAI-1, also called SERPINE-1). Although, the main function of PAI-1 is the regulation of the PAS, it also shares in alternate biological processes implicated in tumorigenesis. Aim of the Study: This review discusses the role of PAI-1 in inhibiting fibrinolysis in oral cancer and its potential as a biomarker and therapeutic target.
La voz de las infancias migrantes venezolanas: el desafío de la estrategia metodológica NAM (Narrativas Migrantes) en el contexto educativo colombiano
Authors: Linares-Alvarado Martha Liliana , Forero-Londoño Oscar Fernando
Published: February 2025

La palabra y las representaciones que el niño y la niña tienen del curso de su vida son un elemento valioso al desarrollar investigaciones sobre la infancia. El presente artículo, hace referencia a la estrategia de campo NAM (narrativas migrantes), una propuesta metodológica que le otorga voz a los niños y niñas en situación migratoria para realizar ejercicios de investigación, lo que implica una visibilización de sus narrativas como agentes sociales. El objetivo del estudio fue identificar las trayectorias de los participantes a partir de tres puntos de inflexión: su origen social, su experiencia migratoria y el empleo de ella como estrategia de reproducción social. Lo anterior está inspirado en la sociología relacional de Pierre Bourdieu a                      fin de ampliar los discursos que se tienen de la infancia venezolana en Colombia.
La estrategia metodológica permitió determinar que,  la implementación del Mosaic Aproach es un recurso valioso para el encuentro con poblaciones vulnerables ya que devela con éxito las narrativas colectivas y particulares de la infancia y,  que para el caso estudiado encarna trayectorias de una migración en crisis. De otro lado, los capitales económicos, escolares y culturales con los cuales transitan los niños, niñas y sus familias inciden en las representaciones que tiene la infancia migrante en el país receptor y específicamente en la escuela. En el anterior sentido, esta propuesta aporta a los investigadores interesados en abordar el tema de la migración infantil y poblaciones de niños y niñas que han visto silenciadas o invisibilizadas sus voces producto de exclusiones o violencias.