bluuebunny/crossref_metadata_2025 huggingface dataset:
Entrenamiento motor en el continuo de la realidad a la virtualidad
Authors: Torres-Narváez Martha , Sánchez-Romero Juanita , Pérez-Viatela Andrea , Betancur Arias Estefanía , Villamil-Ballesteros Jenny , Valero-Sánchez Karen
Published: June 2018

Introducción. La trasformación de la capacidad de movimiento de las personas es un reto que el fisioterapeuta asume como estrategia de aprendizaje motor.Objetivo. Plantear los referentes teóricos y prácticos más relevantes en el uso de ambientes terapéuticos en el continuo de la realidad a la virtualidad en el entrenamiento motor de pacientes con accidente cerebrovascular y enfermedad de Parkinson. Materiales y métodos. Revisión de la literatura que analiza y aporta de manera conceptual, en el área de la rehabilitación y la fisioterapia, información sobre entrenamiento y aprendizaje motor.Resultados. Se evidencia potencial en el uso de la realidad virtual para la rehabilitación de alteraciones del movimiento debidas a disfunciones neurológicas. Las herramientas tecnológicas propias de la realidad virtual permiten un mayor conocimiento de los resultados con respecto a las características del movimiento, lo cual ayuda a mejorar el aprendizaje motor, en comparación con el entrenamiento tradicional.Conclusiones. Se requiere objetivar el proceso de rehabilitación para medir con precisión los cambios que producen estrategias de aprendizaje en las capacidades de movimiento de las personas con deficiencias del sistema neuromuscular para generar evidencia del impacto que tienen los programas de entrenamiento motor en el continuo de la realidad a la virtualidad.
Cancer and mitochondrial function
Authors: Freyre-Bernal Sofía Isabel , Saavedra-Torres Jhan Sebastián , Zúñiga-Cerón Luisa Fernanda , Díaz -Córdoba Wilmer Jair , Pinzón-Fernández María Virginia
Published: June 2018

Metabolism alterations are associated with the loss of mitochondrial function in tumor cells. Current research discuss whether such loss is evident in function itself, or if cells can provide maximum stability to its functions. More studies are needed to determine the behavior of cancer in mitochondria. Tumor cells experience a limitation of oxygen and mutations in oncogenes, tumor suppressor genes and enzymes of the glycolytic pathway and/or mitochondrial oxidative metabolism, thus allowing the formation of aggressive cancer. This article is the result of a literature review of the scientific evidence that has been presented in the latest research on cancer and mitochondrial function.
Supervisor clínico en hospital de mediana complejidad: opinión de estudiantes de nutrición y dietética
Authors: Cisterna-Hidalgo Sara Stephanie , Cabezas-González Mirtha Elizabeth , Illesca-Pretty Mónica Elizabeth
Published: June 2018

Introducción. La importancia de los supervisores clínicos en el proceso de formación de futuros profesionales de la salud es reconocida.Objetivo. Conocer la opinión de estudiantes de la carrera Nutrición y Dietética de la Universidad Autónoma de Chile-Temuco sobre el rol del supervisor clínico en el servicio de medicina interna del Hospital Dr. Dino Stagno como campo clínico en práctica profesional del adulto.Materiales y métodos. Investigación cualitativa, descriptiva e interpretativa. Estudio intrínseco de casos. Muestra no probabilística e intencionada. Para la recolección de datos se realizó entrevista. El análisis de datos siguió un esquema de reducción progresiva. Validación por criterios de rigor y triangulación de investigadores.Resultados. Con 105 unidades de significado emergen cuatro categorías: factores que obstaculizan la realización de la práctica (31), factores que favorecen la realización de la práctica (30), experiencia adquirida en la práctica (28) y cumplimiento objetivos del programa en la práctica (16). Surge un dominio cualitativo.Conclusiones. Realizar la práctica profesional en el servicio de medicina interna adulto es una experiencia positiva para los estudiantes ya que les permite desarrollar el autoaprendizaje, adquirir destrezas y cumplir los objetivos del internado. El recurso humano del hospital es el factor favorecedor y la ausencia y escasa comunicación con el supervisor universitario en el lugar es el factor obstaculizador.
Contaminación de agua en países de bajos y medianos recursos es un problema de salud pública global
Authors: Gómez-Duarte Oscar
Published: June 2018

El agua es un elemento esencial para la vida de todos los seres vivientes del planeta, además es un derecho humano fundamental (1). El 97.2% del agua en el planeta Tierra es salina y solo el 2.5% corresponde a agua fresca; de ese 2.5%, 30% es subterránea, 68% está en los glaciares y otras capas de nieve y solo el 1.2% es superficial y se encuentra en ríos, lagos y otras formas de agua de superficie (2).El agua potable está amenazada por la continua contaminación que genera la actividad humana y por la disminución de los recursos hídricos como consecuencia del calentamiento global (3). Según la Organización Mundial de la Salud, desde el año 2015 solo el 89% de la población mundial tiene acceso a agua apta para consumo y se anticipa que este porcentaje continuará disminuyendo (4), aunque se estima que la situación ya es crítica para 260 millones de personas que carecen de agua apta para el consumo (5).
Leitura e consciência linguística
Authors: Flôres Onici Claro
Published: June 2018

Neste artigo a leitura é vista como uma atividade cognitiva complexa que envolve necessariamente o desenvolvimento da consciência linguística do leitor iniciante, a começar pela consciência fonológica. Nessa perspectiva, aprender a ler exige, antes de qualquer outra coisa, relacionar a fala ao sistema de escrita, vocalizando a produção do fonema correspondente ao grafema escrito, pois o sistema do Português Brasileiro é alfabético. Aos alfabetizadores, recomenda tanto o estudo do sistema fonológico do PB quanto dos fundamentos biológicos da atividade leitora, tanto para entenderem melhor o princípio alfabético quanto os vínculos entre cérebro, linguagem e fala. Além disso, reitera a importância de contextualização do processo de ensino-aprendizado, situando-o no contexto social e cultural do aprendiz, não desconsiderando, pois, o seu conhecimento prévio.
Neurociência cognitiva na sala de aula: estratégias de ensino de Língua Espanhola
Authors: Do Pinho Louise Silva
Published: June 2018

Apresentamos, neste artigo, uma análise de atividades de um material didático elaborado para o ensino de leitura em Língua Espanhola (PINHO, 2015b) que tem como base conceitos da Neurociência Cognitiva (COSENZA; GUERRA, 2011) e do ensino e aprendizagem de leitura (LEFFA, 1996; SCHLATTER, 2009). O objetivo deste trabalho é analisar algumas atividades e estratégias de ensino de Língua Espanhola utilizadas em aulas aplicadas pela pesquisadora na referida pesquisa e observar como elas contribuem com o ensino e a aprendizagem de leitura em língua espanhola. A análise das atividades foi feita com base nos conceitos neurocientíficos de funções cognitivas (percepção, memória, funções executivas e funções expressivas) e em estudos sobre o desenvolvimento da habilidade da leitura. Foi possível verificar que as atividades de compreensão leitora analisadas buscam desenvolver as funções cognitivas durante o processo de aprendizagem da leitura em língua espanhola, além de estimularem o uso de estratégias de leitura.
Tempo da leitura silenciosa e em voz alta com jovens, envelhescentes e pessoas da terceira idade
Authors: Porto Maria Augusta Rocha , Freitag Raquel Meister Ko. , Tejada Julian
Published: June 2018

Este estudo visa aferir o tempo de leitura, em português e em inglês, de modosilencioso e em voz alta, e o controle do movimento ocular (quantidade e duração das fixações e regressões), com três grupos experimentais (10 de cada): jovens, envelh escentes e terceira idade, com o uso de aparelho de eye-tracking EyeTribe. Os resultados apontam que o grupo de participantes jovens se diferenciou dos outros dois grupos, com tempo de 200 a 250ms. O grupo de jovens obteve um tempo maior no inglês do que na leitura em português. Os participantes da terceira idade apresentaram um número muito maior estabelecido ao padrão de leitura de 500ms, apresentando um valor de 600-650ms. Nos textos de inglês, o tempo foi maior entre as três categorias. Os participantes leram os textos em inglês e em voz silenciosa mais rápido do que os textos em voz alta.
Correlação entre fatores de experiência linguística bilíngue e controle inibitório
Authors: Koch Rodrigo Alan , Fontes Ana Beatriz Arêas da Luz
Published: June 2018

Há um debate na literatura quanto à existência da vantagem bilíngue nas funções executivas e fatores linguísticos possivelmente associados a ela. Esta pesquisa exploratória teve por objetivo investigar quais fatores de experiência linguística bilíngue podem estar correlacionados com a vantagem bilíngue no controle inibitório. Descobriu-se que o controle inibitório se correlacionou positivamente com a quantidade de mixing (mistura de duas ou mais línguas ao se comunicar) que os bilíngues efetuavam. Houve também correlação negativa entre o controle inibitório e a idade de aquisição média de uma L3. Ambas as evidências estão em desacordo com as concepções acerca da relação entre fatores de experiência linguística efunções executivas vigentes na literatura, que preveria que a realização de mixing e a idade de aquisição de uma L3 estariam associados a um controle inibitório maior.
O funcionamento de falas sintomáticas para além da distinção normal/patológico: contribuições Saussurianas
Authors: Milano Luiza , Ribeiro Joana De Quadros
Published: June 2018

O presente artigo questiona o estatuto da distinção normal/patológico no âmbito dos estudos dos distúrbios de linguagem. Para tanto, realiza uma reflexão acerca da caracterização linguística de falas sintomáticas baseada em pressupostos teóricos saussurianos. De Ferdinand de Saussure (1974), serão consideradas as noções de linguagem, língua e fala, bem como a teoria do valor e o circuito da fala. Foram analisados dois recortes de dados que apontam que a oposição normal/patológico não sustenta a interpretação linguística de fenômenos envolvidos nestes casos. Dessa forma, o estudo evidenciou elementos que permitem pensar a singularidade do funcionamento da linguagem, a partir das referidas noções saussurianas, sem a necessidade de estandardização na classificação dicotômica normal/patológico.
Desambiguação de sentenças na interface fonologia-sintaxe-semântica
Authors: Othero Gabriel De Ávila , Teixeira Mariana Terra
Published: June 2018

Partimos dos resultados de Angelo & Santos (2017) em sua investigação sobre a desambiguação de sentenças com base em pistas prosódicas para tentar esclarecer uma questão que ficou em aberto em seu trabalho. As autoras realizaram um teste de compreensão com sentenças do tipo SN1-V-SN2-Atributo (e.g. O pai visitou o filho feliz) e chegaram à conclusão de que um alongamento nas sílabas do SN2, formando domínios prosódicos distintos entre SN2 e Atributo ([visitou o filhoϕ] [felizϕ]), favorece uma interpretação não local, em que o Atributo é interpretado como predicativo do sujeito e não como adjunto  adnominal. Entretanto, as autoras perceberam uma variação entre as interpretações com aposição local e não local na compreensão de sentenças sem o alongamento prosódico. Ou seja, segundo as autoras, a ausência da marcação prosódica não favoreceria uma ou outra interpretação, ao passo que a marcação prosódica alongada favoreceria a interpretação não local. Em nosso trabalho, argumentamos que a desambiguação desse tipo de sentença depende basicamente da resolução de um conflito entre três princípios de diferentes naturezas gramaticais que estão atuando em conjunto na desambiguação de sentenças com essa estrutura: um princípio de natureza prosódica, outro de natureza sintático-computacional e outro de ordem semânticopragmática. Para provar nosso ponto, elaboramos um teste off-line de compreensão de sentenças e o aplicamos a 270 informantes. Nossos resultados apontam para uma interação entre esses três princípios na resolução da ambiguidade dessas sentenças.
Construção de uma tarefa de reconhecimento de tradução Libras-Português: considerações metodológicas
Authors: Da Fonseca Sandro Rodrigues , Fontes Ana Beatriz Arêas da Luz , Finger Ingrid
Published: June 2018

Este artigo tem como objetivo refletir sobre aspectos metodológicos importantes a serem adotados na elaboração de uma tarefa psicolinguística que investiga o acesso lexical no bilinguismo bimodal. A Tarefa de Reconhecimento de Tradução Libras e Português apresentada aqui foi construída no decorrer da pesquisa que deu origem à dissertação de mestrado de Fonseca (2015), que investigou o efeito de interferência semântica em bilíngues bimodais ouvintes que atuam como TILS – tradutores e intérpretes de Libras, com distintos níveis de experiência profissional. Este artigo observa em que medida a tarefa atingiu sucesso e discute a necessidade de criar tarefas confiáveis em estudos psicolinguísticos envolvendo línguas de sinais.
Detecting mild cognitive impairment in narratives in Brazilian Portuguese: first steps towards a fully automated system
Authors: Treviso Marcos Vinícius , Dos Santos Leandro Borges , Shulby Christopher , Hübner Lilian Cristine , Mansur Letícia Lessa , Aluísio Sandra Maria
Published: June 2018

In recent years, Mild Cognitive Impairment (MCI) has received a great deal of attention, as it may represent a pre-clinical state of Alzheimer´s disease (AD). In the distinction between healthy elderly (CTL) and MCI patients, automated discourse analysis tools have been applied to narrative transcripts in English and in Brazilian Portuguese. However, the absence of sentence boundary segmentation in transcripts prevents the direct application of methods that rely on these marks for the correct use of tools, such as taggers and parsers. To our knowledge, there are only a few studies evaluating automatic sentence segmentation in transcripts of neuropsychological tests. The purpose of this study is to investigate the impact ofthe automatic sentence segmentation method DeepBond on nine syntactic complexity metrics extracted of transcripts of CTL and MCI patients.***Detecção de comprometimento cognitivo leve em narrativas em Português Brasileiro: primeiros passos para um sistema automatizado***Nos últimos anos, o Comprometimento Cognitivo Leve (CCL) tem recebido bastante atenção, uma vez que pode representar um estado pré-clínico da Doença de Alzheimer (DA). Na distinção entre idosos saudáveis (CTL) e pacientes com CCL, ferramentas de análise automática do discurso têm sido aplicadas a transcrições de narrativas em inglês e em português brasileiro. No entanto, a ausência da segmentação dos limites da sentença em transcrições impede a aplicação direta de métodos que empregam essas pontuações para o uso correto de ferramentas, como taggers e parsers. Segundo nosso conhecimento, há poucos estudos avaliando a segmentação automática de sentenças em transcrições de testes neuropsicológicos. O propósito deste estudo é investigar o impacto do método DeepBond para segmentação automática de sentenças em nove métricas de complexidade sintática extraídas de transcrições de CTL e de pacientes com CCL.
Water conflict on the Mekong River
Authors: Shkara Nadia Deyaa
Published: June 2018

The study deals with the suffering of the Mekong River, which is of great economic value and one of the most important rivers in the world because it is the main source of food, water and economic opportunities for more than sixty million people living on its banks. It is also home to many endangered animals, plants and fish, (Xinhua) - Mekong has caused disturbing changes caused by deadly fishing, deforestation and construction of huge hydroelectric dams, and many observers say the situation is out of control and could lead to increased civil unrest and protests in states such as Myanmar, Cambodia, Thailand, Vietnam and Tibet as a result of this devastating development.
On a set of close-to-convex functions
Authors: Sharma Poonam , Raina Ravinder Krishna , Sokół Janusz
Published: June 2018

In this paper, a class Ss(q) of close-to-convex functions is considered. Among the results studied for this class are its various characteristic properties such as the radius of convexity, certain bounds and coeffcient estimates. A suffcient condition for a function f to be in the class Ss(q), is also obtained.
Menger algebras of idempotent n-ary operations
Authors: Dudek Wieslaw A. , Trokhimenko Valentin S.
Published: June 2018

It is proved that the set of all idempotent operations defined on a given set forms a Menger algebra which can be characterized by its densely embedded v-ideal. We also describe automorphisms of this algebra.
Prevalence, risk factors, and psychosocial adjustment of problematic gambling in adolescents: Results from two representative German samples
Authors: Giralt Sebastián , Müller Kai W. , Beutel Manfred E. , Dreier Michael , Duven Eva , Wölfling Klaus
Published: June 2018

Background and aims

Gambling disorder is a significant public health concern. Especially, male minors have been shown to gamble in a problematic way, despite legal prohibitions.

Methods

We examined representative samples of students aged from 12 to 18 years (N = 9,309) in two German federal states to provide prevalence data and clinical description of risk factors for problematic gambling.

Results

We found that about 40% of the adolescents reported engaging in gambling activities within the past 12 months and found prevalence rates of 1.7% and 2.2% for problematic gambling. Especially, use of online gambling and slot machines was found to be related to problematic gambling. Male adolescents with a migration background were of higher risk for problematic gambling and psychopathological symptoms were significantly elevated among that group.

Discussion

The results indicate that participation in gambling activities is common among underaged adolescents and that prevalence of problematic gambling exceeds rates of adults. Similarly, problematic gambling is associated with increased psychopathological strain.

Conclusion

Given that a high proportion of adult gamblers report having started gambling in adolescents, our data emphasize the need for prevention and early intervention strategies for problematic gambling.
Oppositional defiant disorder/conduct disorder co-occurrence increases the risk of Internet addiction in adolescents with attention-deficit hyperactivity disorder
Authors: Gunes Hatice , Tanidir Canan , Adaletli Hilal , Kilicoglu Ali Guven , Mutlu Caner , Bahali Mustafa Kayhan , Topal Melike , Bolat Nurullah , Uneri Ozden Sukran
Published: June 2018

Objectives

The aims of this cross-sectional study were to assess the prevalence of Internet addiction (IA) in a clinical sample of adolescents with attention-deficit hyperactivity disorder (ADHD) and to detect the moderating effects of co-occurring oppositional defiant disorder/conduct disorder (ODD/CD) on the association between ADHD and IA.

Methods

The study group comprised 119 adolescent subjects who were consecutively referred to our outpatient clinic with a diagnosis of ADHD. The Turgay DSM-IV-Based Child and Adolescent Disruptive Behavioral Disorders Screening and Rating Scale (T-DSM-IV-S) was completed by parents, and subjects were asked to complete the Internet Addiction Scale (IAS).

Results

The IAS results indicated that 63.9% of the participants (n = 76) fell into the IA group. Degree of IA was correlated with hyperactivity/impulsivity symptoms but not with inattention symptoms. As compared to the ADHD-only group (without comorbid ODD/CD), ADHD + ODD/CD subjects returned significantly higher scores on the IAS.

Conclusions

As adolescents with ADHD are at high risk of developing IA, early IA detection and intervention is of great importance for this group. In addition, adolescents with ADHD + ODD/CD may be more vulnerable to IA than those in the ADHD-only group and may need to be more carefully assessed for IA.
Plastic and Presentism
Authors: Hawkins Gay
Published: June 2018

How did a material as tough and durable as plastic became classified as transient anddisposable? This is a temporal question that wrestles with the paradox of how plastic'smaterial endurance and synthetic immortality have been obliterated by economic andcultural practices driven by single use. Disposable plastic things generate a distinct temporalitycharacterized by being immediately present and ephemeral. These things seemto be most definitely in the flow of time: barely there before they are gone, but what doesthis presentism affirm? How does this material realise the present as without history ororigin, and endlessly replaceable? To pursue these issues, historical and sociotechnicalaccounts of plastic and philosophical explorations of the relations between time andmaterials are put into dialogue. In historical approaches plastic is recognized as being intime, in the sense of being caught up in the dynamics of historicity and changing contexts,but it is not recognized as being of time: as actualizing new temporal ontologies.Process philosophers provide key insights into the intersections between plasticity andtemporality and show how materials are simultaneously in and of time.
Queer Times and Chemical Weapons, Suspended in the Gotland Deep
Authors: Neimanis Astrida
Published: June 2018

Following World War II, between 2000 and 10,000 metric tonnes of chemical weapons,mostly mustard gas, were dumped in the Gotland Basin of the Baltic Sea. This articleexplores these dumps as a dense transfer point for many different, sometimes incommensurabletemporalities. Guided by queer theories of nonlinear temporality, I describethese sulphur mustard times as both making and being made by the materialities of thechemicals, their containers, the bodies with which they come into contact and the sea.These knots of temporalities articulate militarisms and environmentalisms in a tangle ofmultiple pasts and possible futures.
Ice and Concrete
Authors: Simonetti Cristián , Ingold Tim
Published: June 2018

Recent environmental changes have sparked off unprecedented dialogues between practitioners of the earth sciences and the humanities, which defy some of the basic assumptions underpinning western science. However, a gap still persists between natural scientists and scholars in the humanities in their tendency to concentrate respectively on the solid matter and fluid meaning. This article seeks to close this gap by paying attention to glacial ice and concrete, materials that often mark the onset and culmination of human history and have been historically regarded as solid fluids. We suggest that ice and concrete are caught in a punctuated understanding of change that turns fluidity and solidity into mutually exclusive properties. The article concludes by comparing this oxymoronic syndrome with the ways the Inuit of West Greenland experience their cryogenic landscapes as nurturing environments in constant becoming.
Technofossil
Authors: Dibley Ben
Published: June 2018

In the process of formally identifying a geological interval, it is crucial for stratigraphersto find the point at which strata reveal a significant, dramatic shift in the types of fossilsand other geological markers being found. In the nomenclature of the discipline thispoint constitutes a "golden spike". For the geologists advancing the proposition that theAnthropocene might be formalized as the Earth's latest interval on the geologic time scale,this spike will be registered by the sudden appearance of a new sedimentary layer - onedecisively marked by the presence of "technofossils". From the proliferation of deepperforations of the strata by mining to the wide distribution of rare elements (aluminum,titanium, uranium) and novel compounds (plastics), for the geologists advocating thenotion of the Anthropocene, the deposits of human technology buried in the Earth's crustwill not only be that species' geological legacy, but the mineral markers of its emergenceas a major geo-force. No doubt the logos of the technofossil is important for geologistsmaking the case for the Anthropocene's formalization as a geological interval; its pathos,however, is of equal import in building a public for it. In the hands of the Anthropocene'sstratigraphers the prospective mineralization of human activity is also the species' anticipatedmemorialization: literally written in stone, the strata of the Anthropocene will bea memorial to human existence - to the era of its doing and undoing. In this, then, thetechnofossil is as much a memento mori as it is a heuristic for imagining a world after thehuman - a "world without us". It is this conjuncture that this paper explores.
Durable Remains
Authors: Resnick Elana
Published: June 2018

Bulgarian Roma living in the capital city of Sofia rely on glass for EU-era survival becauseof its role in food-jarring practices and its ability to be repeatedly used and reused withoutbreaking down. The durability of glass emerges as a salient material quality for ensuringa means of preservation in the face of everyday economic precarity. Glass's durability ismaterial and temporal: temporal in that it transcends political and economic upheavals,and material in that, unlike plastic, metal and paper, glass does not naturally decomposeover time. Instead, it enables structurally disadvantaged urbanites, like the Roma, touse homegrown food packaging technologies in order to survive in the era of EU "free"markets, plastic packaging and neoliberal discardability. The temporal and materialdurability of glass juxtaposes the precarious circumstances of those most engagedwith its contemporary reuse for whom glass enables both survival and a form of EU-eramaterial citizenship. However, EU regulations focused on recycling fail to acknowledgethe widespread practice of glass reuse in Bulgaria. This paper analyzes how EU policy,recycling company officials and Romani and non-Romani Sofia residents reconfiguredurability through different temporal materialities - and practices - of recycling and reuse.
Ice Cores as Temporal Probes
Authors: Salazar Juan Francisco
Published: June 2018

This article develops a speculative approach to thinking about the temporalities of ice.Examining the politics of ice cores as temporal probes, it argues that ice comes to matterin political and ecological terms and as the very "stuff of time". As cylinders of ice thatare extracted through drilling into the deep time of extreme cryogenic environments, icecores become speculative devices to conceive of climates past and future. An analysisof ice-coring practices and technologies as time capsules or temporal probes allowsfor a novel way of thinking about the temporal materialities of ice and its vibrancies anddistributive agency, and how the material-semiotic entanglements of ice-coring practicesbecome a way of listening to the call of matter.
VHL-Associated Optic Nerve Hemangioblastoma Treated with Stereotactic Radiosurgery
Authors: Kanno Hiroshi , Osano Seiki , Shinonaga Masamichi
Published: June 2018

Central nervous system hemangioblastomas are generally restricted to the cerebellum, spinal cord, and brainstem. Supratentorial hemangioblastomas are uncommon, and optic nerve hemangioblastomas are extremely rare, with fewer than 25 reports including this case. In this report, we present the case of a 36-year-old woman with von Hippel–Lindau (VHL) disease who presented with progressive diminution of vision in the left eye due to a retrobulbar optic nerve hemangioblastoma. The patient had a history of cerebellar/spinal hemangioblastomas and pancreatic cysts, and her father and brother were patients with VHL disease. Gadol-inium-enhanced magnetic resonance imaging showed intraorbital retrobulbar–enhanced mass on the left optic nerve. The optic nerve hemangioblastoma was treated with fractionated stereotactic radiosurgery using Novalis. Eighteen months after the stereotactic radiosurgery, the tumor volume decreased although the patient lost vision. This report presents an extremely rare case of optic nerve hemangioblastoma, which is the first case treated with stereotactic radiosurgery.
Fifteen Years of Platelet Rich Fibrin in Dentistry and Oromaxillofacial Surgery: How High is the Level of Scientific Evidence?
Authors: Ghanaati Shahram , Herrera-Vizcaino Carlos , Al-Maawi Sarah , Lorenz Jonas , Miron Richard J , Nelson Katja , Schwarz Frank , Choukroun Joseph , Sader Robert
Published: June 2018

Platelet-rich fibrin is a blood concentrate system used for soft tissue and bone tissue regeneration. In the last decade, platelet rich fibrin (PRF) has been widely used in different indication fields, particularly in oral and maxillofacial surgery. This review investigates the level of scientific evidence of published articles related to the use of PRF for bone and soft tissue regeneration in dentistry and maxillofacial surgery. An electronic literature research using the biomedical search engine “National Library of Medicine” (PubMed-MEDLINE) was performed in May 2017. A total of 392 articles were found, 72 of which were classified for each indication field. When comparing PRF with biomaterials vs biomaterial alone in sinus lift (5 studies; IIa), no statistically significant differences were detected. Socket preservation and ridge augmentation using PRF significantly enhanced new bone formation compared to healing without PRF (7 studies Ib, IIa, IIb). Reepithelialization and bone regeneration was achieved in 96 of 101 patients diagnosed with medication-related osteonecrosis of the jaw (5 studies, III). In periodontology, PRF alone (6 studies; Ib, IIa, IIb) or its combination with biomaterials (6 studies; Ib, IIa, IIb) significantly improved the pocket depth and attachment loss compared to a treatment without PRF. Over 70% of the patients were part of studies with a high level of scientific evidence (randomized and controlled prospective studies). This published evidence (38 articles), with a high scientific level, showed that PRF is a beneficial tool that significantly improves bone and soft tissue regeneration. However, the clinical community requires a standardization of PRF protocols to further examine the benefit of PRF in bone and soft tissue regeneration in reproducible studies, with a higher scientific level of evidence.
Projeto de desenvolvimento de bebidas lácteas com soro do leite: um método com uma nova abordagem de PCP
Authors: Nunes Luane Alcântara , Gerber Juliano Zaffalon , Costa Flávio Pietrobon , Kalid Ricardo de Araújo , Teixeira Cássio Lindemberg Santana , Tanajura Carolina Navaes
Published: June 2018

O objetivo deste artigo é planejar a produção de bebidas lácteas a partir do soro do leite disponível na Região Litoral Sul da Bahia, por meio de um método estruturado que incorpora uma nova abordagem de Planejamento e Controle da Produção - PCP, ao considerar técnicas de previsão de demanda e simulação computacional. Foi possível definir o público alvo para distribuição das bebidas lácteas, além de todo o escopo para a produção do produto, com a determinação dos parâmetros do modelo, fluxograma do processo, equipamentos, pessoal necessário, estratégias de produção, balanceamento e validação de um cenário ótimo de produção. Este artigo funciona, portanto, como uma proposta de dimensionamento da etapa de produção dentro da cadeia de suprimentos de valorização do soro do leite, além de favorecer, quando as soluções propostas forem implantadas, na geração de emprego e renda e na redução da poluição ocasionada pelo mau aproveitamento deste coproduto pelos produtores de queijo.
Pesquisa científica como fonte de inovação em hospitais altamente reconhecidos no Mundo e no Brasil
Authors: Abbade Eduardo Botti
Published: June 2018

A gestão eficiente do conhecimento e da inovação é encarada como orientação capaz de conduzir organizações a patamar de excelência e elevado desempenho. O engajamento de organizações no desenvolvimento de pesquisas científicas e produção acadêmica pode ser visto como indicador associado ao grau de inovação e construção de conhecimento acerca de melhores práticas e tecnologias. Dessa forma, este estudo objetivou analisar o nível de produtividade acadêmico-científica dos maiores hospitais mundiais e brasileiros, relacionando tal produtividade com a posição de excelência e destaque no setor hospitalar em nível mundial. Foram selecionados os 10 maiores hospitais mundiais e os 10 maiores hospitais brasileiros, com expressivo reconhecimento em termos de excelência e qualidade. Foi considerado o ranking dos hospitais mundiais apresentado pelo Portal Hospitals–Webometrics (2015) assim como as publicações acadêmicas registradas no portal SCOPUS para cada um dos 20 hospitais selecionados. Os resultados sugerem que existe uma forte associação entre a posição de excelência e reconhecimento mundial dos hospitais com seus respectivos níveis de produtividade acadêmico-científica. Ademais, observou-se a produtividade científica está fortemente concentrada nas áreas médicas em todos os 20 hospitais considerados. Dentre os hospitais brasileiros, os que apresentam maior destaque em produção acadêmico-científica são o Instituto do Coração do Hospital das Clinicas e o Hospital de Clinicas de Porto Alegre.
A Gestão do Processo de Desenvolvimento de Produtos em empresas fornecedoras de bens de capital para o setor sucroenegético
Authors: Onoyama Marcia Mitiko , Toledo José Carlos , Lizarelli Fabiane Leticia , Santos Adriana Barbosa
Published: June 2018

O trabalho analisa a gestão do Processo de Desenvolvimento de Produtos (PDP) em uma amostra de empresas industriais fornecedoras de bens de capital para o setor sucroenergético. Foi conduzido um survey utilizando um questionário aplicado in loco junto aos responsáveis pelo desenvolvimento de produtos numa amostra de 31 empresas. Análise de cluster foi realizada para classificar as empresas pelo grau de estruturação de procedimentos estratégicos e operacionais, considerados relevantes para a maturidade do PDP. Três grupos de empresas foram identificados e os resultados obtidos foram expostos de forma comparativa. Na dimensão estratégica verificaram-se diferenças mais acentuadas entre os grupos em relação ao grau de formalização das atividades e uso de métodos, indicando a necessidade de fortalecimento das atividades estratégicas de gestão do PDP. A dimensão operacional mostrou-se mais estruturada do que a estratégica de forma geral e, em relação a avaliação do desempenho, se percebe a falta de mecanismos de monitoramento e avaliação dos resultados do PDP, e pouca valorização de programas de capacitação e de acompanhamento da qualificação do pessoal.
KOROVKIN THEOREM VIA STATISTICAL e-MODULAR CONVERGENCE OF DOUBLE SEQUENCES
Authors: YILDIZ Sevda
Published: June 2018

In the present paper, we obtain an abstract version of the Korovkin type theorem via the concept of statistical e-convergence in modular spaces for double sequences of positive linear operators. We give an application showing that the new result is stronger than classical ones. Also, we study an extension to non-positive operators.
Kan Althusius die politokrate red?
Authors: Raath A
Published: June 2018

In 'n bydrae tot die debat oor die grondslae van politokratiese kommunitarisme, het Danie Goosen in die Desember 2016-uitgawe van hierdie tydskrif beweer dat die idee van die Griekse polis voortlewe deur Johannes Althusius se moderne federale politieke teorie van die sewentiende eeu. In hierdie artikel word die houdbaarheid van Goosen se standpunt in die lig van Althusius se onderskrywing en toepassing van die Ramistiese logika en dialektiese metodologie ondersoek. Ramus se logika was nie gewortel in die Aristoteliese sillogisme nie, maar in definisies en Stellings behorende tot die betrokke empiriese wetenskapsterreine. Althusius het 'n duidelik onderskeibare Reformatoriese inslag aan die Ramistiese metodologie verleen. Dié metodologie sou as 'n beperkte vorm van transendentaal-empiriese metodologie beskryf kon word. In hierdie artikel word geargumenteer dat die filosofiese wortels van politokratiese kommunitarisme in direkte teenstelling staan tot Althusius se politieke teorie. Die implikasie is dat die politokratiese onderskrywing en akkommodering van Althusius se politieke standpunte vereis dat die Aristotelies-universalistiese statisme en die onderliggende idee van diensbaarheid aan die belange (en behoeftes) van die organismiese staat vaarwel toegeroep sal word. Althusius se insig in die onderskeid tussen die strukture van die burgerlike samelewing en die staat as publiekregtelike instelling, noodsaak die verwerping van die kernidees van politokratiese kommunitarisme tot die mate dat laasgenoemde 'n vergestalting van abstrakte gemeenskapslewe is, dit 'n totalitêre (en absolutistiese) vorm van politieke gemeenskap omhels, dit fundamentele burgerregte verwerp en 'n innerlik teenstrydige en ongedifferensieerde vorm van politieke assosiasie weerspieël.
Dagloners: 'n Gevallestudie van die kwesbaarheid van die maatskaplike bestel en samehorigheid in Suid-Afrika se informele ekonomie
Authors: Schenck R , Blaauw D
Published: June 2018

Dagloners is werklose mense, meestal mans, wat 'n poging aanwend om 'n inkomste te verdien deur hul arbeid en vaardighede in 'n arbeidsmark langs die pad of by 'n kruising te verkoop. Die groeiende aantal dagloners wat 'n lewe uit informele indiensname maak, is 'n duidelike teken dat Suid-Afrika nie die werkloses in die arbeidsmark kan absorbeer nie - veral nie die laag- en ongeskoolde arbeiders nie. Om in die informele ekonomie te oorleef en 'n bestaan te maak, impliseer n onsekere inkomste en bestaan. Hierdie nasionale studie is in twee fases uitgevoer. Tydens 'n verkenningsfase het die outeurs n landwye verkenning in 2005 en 2006 onderneem. Dit het 'n geskatte aantal dagloners in Suid-Afrika van tussen 45 000 en 50 000 opgelewer. Die tweede fase van die studie het bestaan uit die ontwerp van die vraelys, die opstel van die steekproef vir die gevallestudie asook die uiteindelike veldwerk. Die steekproef is saamgestel proporsioneel tot die aantal dagloners wat in die geïdentifiseerde stede en dorpe aanwesig was tydens die eerste fase van die projek. Die outeurs het van bondelsteekproefneming en sneeubalsteekproefneming gebruik gemaak om te verseker dat die dagloners in stedelike en landelike gebiede nie onder- of oorverteenwoordig word nie. Die opleiding van die veldwerkers het deeglike aandag geniet en die veldwerk self het van Februarie 2007 tot November 2008 geduur, waartydens 3 830 onderhoude gevoer is. Alle etiese oorwegings het ook deeglike aandag ten tye van die navorsing geniet. Die doel van die artikel is om die sosio-ekonomiese profiel van dagloners in Suid-Afrika te beskryf as 'n gevallestudie wat illustreer watter druk op die maatskaplike samehorigheid van die gesinne en gemeenskappe in die informele ekonomie geplaas word. Daar word in besonder aandag gegee aan die sosio-ekonomiese omstandighede van die dagloners en die beleids- en institusionele maatreëls wat ingestel moet word om ondersteuning aan die dagloners te kan bied, sodat samehorigheid bevorder kan word en nie bedreig word, soos tans die geval is nie.
Bacterial DNA extraction from blood using QIAGEN DNeasy & Tissure Kit v1
Authors: Watanabe Nobuo , Inoue Shigeaki
Published: June 2018

We show our protocol to isolate total DNA from blood using QIAGEN DNeasy & Tissue Kit. The DNA can be used for identification of pathogenic bacteria by next generation DNA sequening.
Pseudoexfoliative glaucoma and molecular genetic characteristics of vitamin D metabolism
Authors: Beletskaya Inessa S. , Astakhov Sergey Yu. , Karonova Tatiana L. , Galkina Olga V. , Bogdanova Evdokia O. , Akopov Evgeniy L. , Kozyreva Alexandra A.
Published: June 2018

Purpose. To study the possible association of 25-hydroxyvitamin D level, and vitamin D receptor (VDR) gene polymorphisms (BsmI, ApaI, TaqI, FokI) with pseudoexfoliative glaucoma (PEG) clinical manifestations.

Methods. We examined 160 subjects (72 males (45%), and 88 females (55%)) aged from 55 to 75 years, residents of St. Petersburg and Leningrad region. 122 patients with PEG were enrolled in the main study group, the control group comprised 38 subjects without PEG, primary open angle glaucoma (POUG) and pseudoexfoliation syndrome (PES). 25(OH)D serum levels were assessed by chemiluminescent immunoassay (CLIA) method. Detection of VDR gene allele polymorphisms (ApaI, BsmI, FokI, and TaqI) was carried out using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) technique.

Results. Patients with PEG had lower 25(OH)D serum levels compared to patients in the control group (39.3 1.2 and 52.7 2.1 nMol/l, respectively, p 0.01). The prevalence of vitamin D deficiency was found to be higher among PEG patients than among healthy subjects (86.4% and 59.5%, respectively, p 0.01). The prevalence of b allele (p 0.001) and bb genotype (p 0.001) (BsmI polymorphism), as well as of f allele and ff genotype (p 0.05) (FokI polymorphism) in PEG patients were higher compared to healthy subjects. We found that the Fallele carriers (FokI polymorphism) had greater corneal thickness than the ff genotype carriers (547.3 4.1 m and 502.1 25.8 m, respectively, p 0.01). It was revealed, that bb genotype, Bb genotype (BsmI polymorphism), and ff genotype (FokI polymorphism) were associated with the increased risk of PEG (OR = 8.2, CI 95%: 3.4-19.9; OR = 3.9, CI 95%: 1.7-9.0; OR = 2.3, CI 95%: 1.2-4.5, respectively).

Conclusions. Results of this study for the first time ever showed the association between BsmI and FokI VDR gene polymorphisms and pseudoexfoliative glaucoma.
Current approaches to the problem of carrier selection for limbal stem cells cultivation in the treatment of limbal stem cell deficiency
Authors: Kulikov Alexey N. , Churashov Sergey V. , Chernysh Valeriy F. , Blinova Miralda I. , Alexandrova Olga I. , Karpovich Vadim V. , Khorolskaya Yulia I.
Published: June 2018

Diseases and damages of the ocular surface are one of the common causes of decreased vision and blindness. Dysfunction or death of limbal epithelial stem cells (LESC) plays an important role in the development of pathological processes in these conditions, which leads to the development of the limbal stem cell deficiency (LSCD). Currently, one of the methods to treat LSCD is a transplantation of cultured ex vivo LESC. The most common carriers for the cultivation of LESC in the world is the amniotic membrane (AM). However, the presence of certain disadvantages in using AM for the cultivation of LESC compels to search new types of carriers made from biological or synthetic materials. In this review, we have analyzed various types of carriers: collagen, fibrin, chitosan with gelatin, silk fibroin, keratin, contact lenses, polylactide-co-glycolide, polycaprolactone, and the possibility of their application as carriers for the LESC cultivation followed by transplantation on the ocular surface is considered.
Therapeutic efficacy of 3% NaCl hypertonic solution in postoperative corneal edema
Authors: Khripun Kirill V. , Nizametdinov Yulduz Sh. , Varganova Tatyana S.
Published: June 2018

Currently phacoemulsification (PE) is the main technique of cataract surgery, which provides for patients early clinical and functional rehabilitation. Post-operative corneal edema is a frequent and undesirable clinical situation.

The purpose of the study was to evaluate clinical efficacy of 3% sodium chloride (Ocusaline) treatment in patients with corneal edema in the early post-operative period.

Materials and methods. 60 patients (65 eyes) with post-operative corneal edema were included in the study. The main group consisted of 35 eyes; 30 eyes were included into the control group. Patients in the group 1 in addition to the routine post-operative treatment were treated with 3% sodium chloride hypertonic eye drops (Ocusaline); and patients in group 2 were treated according to the standard protocol. In all patients before and after surgery (in 1 day, 7 days and 1 month), subjective and objective indices of functional ophthalmic state (visual acuity, pachymetry in the central area and in the tunnel incision zone) were estimated.

Results. The study results demonstrated that 3% sodium chloride hypertonic solution use facilitates visual acuity improvement due to the decrease of corneal thickness in the central area already at one week after surgery. The use of Ocusaline in the early post-operative period allows to decrease clinical and functional rehabilitation terms and to reduce subjective complaints of patients.
Unilateral mydriasis after video-assisted thoracic thymectomy: case report and review of literature
Authors: Panova Tatiana Yu. , Nikolaenko Vadim P.
Published: June 2018

The article reviews a clinical case of unilateral mydriasis after uncomplicated video-assisted thoracic thymectomy as well as results of literature data analysis of.
Chronic kidney disease-prevalence and determinants among type 2 diabetes mellitus patients attending a primary care setting in central Kerala
Authors: Soman Sajith Kumar , Areekal Binu , Varghese Rosin George , John Susan , Gopan Radhika S. , Jacob Quincy Mariam , Nair Amruthaa Raman
Published: June 2018

Background: Diabetes mellitus (DM) is one of the most common metabolic diseases characterized by increased blood glucose levels either due to insufficiency/absence of insulin or due to decrease in the insulin sensitivity. The prevalence of chronic kidney disease (CKD) in people with type 2 diabetes is three times higher than in non-diabetic population and majority of people developing end-stage renal diseases (ESRD) have Type 2 DM. The objectives of the study were to find out the prevalence of CKD, mean GFR and associated factors of CKD, in diabetics coming to a primary health care setting in Central Kerala.Methods: A cross-sectional study among all patients attending the NCD clinic of Health Centre, Ettumanoor with confirmed diagnosis of type 2 diabetes mellitus was done between February 2017 and April 2017.Results: The prevalence of CKD among the study population was 45.3%. The proportion of CKD was 34.9% among those with nil urinary protein, 57.1% among those with 1+ urinary protein, 88.9% for those with 2+ and 87.5% among those with 3+ urinary protein. Among those with CKD mean duration of diabetes was 121.92 months against 92.72 months among those without CKD. There was statistically significant difference between RBS values of those with CKD and without CKD (238.49 mg% versus 199.41 mg%). The proportion of CKD was found increase with duration of diabetes 5 years (31.2%), 5-10 years (47.8%), 10-15 years (52.6%) and >15 years (55%).Conclusions: The study showed high prevalence of CKD among diabetics. The duration of diabetes, urinary protein levels and RBS value were found to have strong association with CKD in diabetics.
Awareness of Potential Complications of Self-Medication- A “Selfie” Generation
Authors: Sowmya B. Devi , Gnanaselvimerlinjeyarani G. , Sibu S. , Fenn Saramma Mathew
Published: June 2018

Self-medication is the major trend observed globally. Inadvertent consequences of self-medication include adverse drug reactions, incorrect dosage, and drug dependence to cite a few. A few of the common explanations fostering self-medication are formal education, family, availability of drugs and exposure to medical websites that provide information on diseases and health conditions. Patient prescriptions of friends and family are other sources utilized for obtaining over the table medicines. This short study is focused on the awareness of self-medication among patients and its potential adverse reactions.