bluuebunny/crossref_metadata_2025 huggingface dataset:
Microwave Irradiation Syntheses and Crystal Structures of Two Series of Novel Fivemembered Heterocyclic Mono-Imine Compounds
Authors: Su Biyun , Li Yaning , Pan Dandan , Faida Paison , Yan Tingyu , Qu Zhan
Published: December 2018

Aim and Objective:

The late transition metal complexes with five-membered heterocyclic
mono-imine ligands have attracted much attention because of their potential application in olefin polymerization
catalysis. In order to increase the coordination ability of heteroatom N and S to center metals, CH3 group
was introduced into the side arm of pyrrole imine and thiophene imine respectively, to get two series of novel
five-membered heterocyclic imine compounds, mono(imino)pyrroles and mono(imino)thiophenes

Materials and Methods:

Two series of novel five-membered heterocyclic compounds with the mono-imine
group were synthesized from the p-toluene sulfonic acid catalyzed Schiff base condensation of aromatic
amines and 2-acetylpyrrole/ 2-acetylthiophene respectively, using CH3 group to substitute the common H atom
on the side arm of pyrrole imine/ thiophene imine.

Results:

All the heterocyclic mono-imine compounds were characterized adequately by means of 1H NMR, 13C
NMR, FT-IR, elementary analysis, as well as X-ray crystallographic diffraction. The reactivity differences
between two precursor 2-acetylpyrrole and 2-acetylthiophene with aromatic amines were compared and
discussed in detail.

Conclusion:

Compared to traditional heating methods, the solvent-free microwave irradiation seemed more
efficient to prepare these series of five-membered heterocyclic mono-imine compounds, which resulted in a
higher yield and cleaner product.
Green Formation of Novel Pyridinyltriazole-Salicylidene Schiff Bases
Authors: Gümüş Mustafa Kemal
Published: December 2018

Aim and Objective:

In this work, water was used as solvent for the eco-friendly synthesis of imines
under microwave irradiation. In the first step of the study, 5-pyridinyl-3-amino-1,2,4-triazole hydrochlorides
were synthesized in the reaction of amino guanidine hydrochloride with different pyridine carboxylic acids under
acid catalysis. A green method for 5-pyridinyl-3-amino-1,2,4-triazoles was developed with the assistance
of microwave synthesis. In the second step, the eco-friendly synthesis of imines was achieved by reacting 5-
pyridinyl-2H-1,2,4-triazol-3-amine hydrochlorides with salicylic aldehyde derivatives to produce 2-(5-
pyridinyl-2H-1,2,4-triazol-3-ylimino)methyl)phenol imines.

Materials and Methods:

Microwave experiments were done using a monomode Anton Paar Monowave 300
microwave reactor (2.45 GHz). Reaction temperatures were monitored by an IR sensor. Microwave experiments
were carried out in sealed microwave process vials G10 with maximum reaction volume of 10 mL.

Results:

When alternative methods were used, it was impossible to obtain good yields from ethanol. Nevertheless,
the use of water was successful for this reaction. After 1-h microwave irritation, a yellow solid was obtained
in 82% yield.

Conclusion:

In this work an eco-friendly protocol for the synthesis of Schiff bases from 5-(pyridin-2-, 3- or 4-
yl)-3-amino-1,2,4-triazoles and substituted salicylic aldehydes in water under microwave irradiation was developed.
Under the found conditions the high yields for the products were achieved at short reaction time and
with an easy isolation procedure.
Xanthine Oxidase Inhibition, In Vitro Antioxidant Activity and Antibacterial Effect of the Aerial Part Extracts of Thymus pallidus Coss
Authors: Benslama Abderrahim , Boumerfeg Sabah , Aouachria Sana , Guemmaz Thoraya , Arrar Lekhmici , Khennouf Seddik , Baghiani Abderrahmene
Published: December 2018

Background:

The Algerian medicinal plant Thymus pallidus Coss. is traditionally known
to be used as an anti-infective, expectorant, healer of wounds and against inflammatory and gastrointestinal
diseases.

Objective:

The aim of the present study is to investigate the antioxidants and the antibacterial activities
of the aerial part extracts of this plant.

Methods:

Polyphenols extraction was performed with methanol 85%, followed by preliminary fractionation
based on the polarity of the solvent. The extraction and fractionation process gave the crude
extract (CrE), chloroform extract (ChE), ethyl acetate extract (EtAE) and aqueous extract (AqE). The
antioxidant activity of extracts was evaluated using in vitro assays. While the antimicrobial activity
was determined using disk diffusion method.

Results:

Quantitative analysis of polyphenol and flavonoids showed that EtAE includes the highest
amount (P≤0.001) with 495.12±1.91 μg GAE/mg of extract and 97.25±2.84 μg QE/mg of extract, for
both polyphenols and flavonoids respectively. The results of the antioxidant activity of extracts
showed that the EtAE exhibited the highest inhibition activity on XO (IC50 =51.6±0.2 μg/ml) compared
to other extracts (P≤0.001). Moreover, the EtAE was the most effective fraction in free radical
scavenging assay against ABTS radical and hydrogen peroxide (EC50= 3.21±0.03 μg/ml and EC50
=12.12±0.05 μg/ml, respectively) compared to other extracts (P≤0.01). Using β-carotene/ linoleic acid
bleaching assay, the AqE and ChE recorded a considerable inhibition effect on linoleic acid oxidation
with a ratio of 81.81% and 80.86%, respectively. In the antimicrobial activity evaluation, the extracts
exhibited moderate antibacterial activity against bacterial strain, with inhibition zone ranging
from 07 to 14 mm. In addition, the EtAE showed a good action spectrum against six bacterial strains.
In conclusion, the EtAE of Thymus pallidus showed good antioxidant activity and antibacterial effect.

Conclusion:

The obtained results revealed the presence of a strong correlation between the antioxidant
and antibacterial activities of the extract and its total phenolic content. Furthermore, they reported
that the EtAE has a considerable antioxidant capacity. This can be considered as an alternative natural
source of antioxidants used generally as additives in food and pharmaceutical preparation.
Evaluation of Hospital Discharge Prescriptions in the Elderly and Younger Adults Using the Medication Regimen Complexity Index
Authors: Balodiya Sujit , Kamath Ashwin
Published: December 2018

Background:

Advances in the clinical management of diseases have been accompanied by
increasing complexity of treatment regimens. The complexity of medication regimen is of concern for
patients as well as doctors as it may adversely affect patient compliance and treatment outcomes. It
may result in medication errors, increased utilization of health resources owing to a reduction in
treatment effectiveness, and increased risk of therapeutic failure.

Objective:

This study aimed to assess the complexity of medication regimen prescribed to patients on
hospital discharge using the medication regimen complexity index (MRCI).

Methods:

A cross-sectional, descriptive study was conducted. Hospital discharge prescriptions written
for patients discharged from the General Medicine wards of a tertiary care teaching hospital in South
India were scored for their complexity using MRCI. The correlation of age and gender with the MRCI
scores was also assessed. Patients ≥60 years of age were considered elderly.

Results:

The median MRCI score for 563 prescriptions studied was 14 (Interquartile range, 9−21).
Elderly patients received a significantly more complex medication regimen compared with younger
patients (p < 0.001) at the time of hospital discharge. Gender variation was seen with higher MRCI
scores in females, but this was not statistically significant in the elderly group.

Conclusion:

MRCI scores are significantly high in elderly patients at the time of hospital discharge.
Although a strong correlation is seen between the number of medications and the MRCI score, the
latter helps to distinguish regimen complexity between prescriptions with the same number of
medications.
Advanced Non-Small Cell Lung Cancer with Activating Epidermal Growth Factor Receptor Mutation: First Line Treatment and Beyond
Authors: Rocco Danilo , Battiloro Ciro , Gravara Luigi Della , Gridelli Cesare
Published: December 2018

Background:

Lung cancer is the leading cause of cancer mortality, being responsible for more than 1.6 million deaths each year worldwide and non-small-cell lung cancer (NSCLC) accounts for approximately 85% of lung cancers; moreover, 10 to 15% of all NSCLCs harbor EGFR (epidermal growth factor receptor) activating mutations, being suitable for EGFR-Tyrosine Kinase Inhibitors (TKI) molecular targeted therapy. However, EGFR+ NSCLCs gain acquired resistance to these agents, representing one of the key challenges for modern precision oncology.

Objective:

herefore, this paper aims to provide an extensive state of the art review, alongside with hints about future perspectives.

Conclusion:

To date, in the light of the data from the FLAURA study, osimertinib represents the best first-line option in NSCLC patients with EGFR activating mutations; EGFR-TKI plus chemotherapy combination therapies, even though interesting, must still be considered investigational.
Study of a New Plaster Composite Based on Dune Sand and Expanded Polystyrene as Aggregates
Authors: Laoubi Hamza , Bederina Madani , Djoudi Amina , Goullieux Adeline , Dheilly Rose Marie , Queneudec Michele
Published: December 2018

Introduction:

This study aims to highlight the physicomechanical properties of a new lightweight construction material which is composed of plaster as a binder and dune sand and Expanded Polystyrene Beads (EPS) as aggregates.

Methods:

For this purpose, different mixtures were designed with different percentages and particle sizes of EPS aggregates in order to test the porosity, the density and the thermo-mechanical properties of the studied composite. Furthermore, Electron Microscopy (EM) visualisation and SEM analysis were used for the study of the structure and the interface “paste-aggregates”.

Results and Conclusion:

The obtained results showed that the progressive incorporation of an increasing percentage of PSE decreases the density of the plaster composite and consequently improves its thermal properties. As expected, the mechanical strength decreases with the increase of the EPS content, but relatively good mechanical strength can be obtained with low quantities of EPS. Concerning the material structure, it should be noted that the composite appears more or less homogeneous and the EPS beads adhere well to the plaster matrix.
Brain Tumor Detection from MR Images Employing Fuzzy Graph Cut Technique
Authors: Dogra Jyotsna , Jain Shruti , Sharma Ashutosh , Kumar Rajiv , Sood Meenakshi
Published: December 2018

Background:

This research aims at the accurate selection of the seed points from the
brain MRI image for the detection of the tumor region. Since, the conventional way of manual seed
selection leads to inappropriate tumor extraction therefore, fuzzy clustering technique is employed
for the accurate seed selection for performing the segmentation through graph cut method.

Methods:

In the proposed method Fuzzy Kernel Seed Selection technique is used to define the complete
brain MRI image into different groups of similar intensity. Among these groups the most accurate
kernels are selected empirically that show highest resemblance with the tumor. The concept of
fuzziness helps making the selection even at the boundary regions.

Results:

The proposed Fuzzy kernel selection technique is applied on the BraTS dataset. Among the
four modalities, the proposed technique is applied on Flair images. This dataset consists of Low
Grade Glioma (LGG) and High Grade Glioma (HGG) tumor images. The experiment is conducted
on more than 40 images and validated by evaluating the following performance metrics: 1. Disc
Similarity Coefficient (DSC), 2. Jaccard Index (JI) and 3. Positive Predictive Value (PPV). The
mean DSC and PPV values obtained for LGG images are 0.89 and 0.87 respectively; and for HGG
images it is 0.92 and 0.90 respectively.

Conclusion:

On comparing the proposed Fuzzy kernel selection graph cut technique approach with
the existing techniques it is observed that the former provides an automatic accurate tumor detection.
It is highly efficient and can provide a better performance for HGG and LGG tumor segmentation in
clinical application.
Source Redundancy Management and Host Intrusion Detection in Wireless Sensor Networks
Authors: Singh Vijander , Sharma Gourav , Poonia Ramesh C. , Trivedi Narendra K. , Raja Linesh
Published: December 2018

Background:

Intrusion Detection System (IDS) is a Software application which gives the
facility to monitor the traffic of network, event or activities on network and finds out any malicious
operation if present.

Objective:

In this paper, a new protocol was developed that can detect the Wireless Network Attack
based on the reference of TCP/IP Model. In the proposed system the new feature is integrated in the
IDS which are built in the router itself.

Methods:

If any intruder tries to connect with router, intruder has to authenticate himself/herself. To
find the authentication key the intruder attacks on the router to matches the authentication key with
the key which he/she has. The intruder has a file with the multiple different keys in it and with that
file intruder applies a brute-force attack on the router, the brute-force checks every key of the file by
applying them on the router when a key matches with the authenticated key the brute-force software
inform the intruder about the key matching. The IDS of the router will checks the rapid tries arriving
from the same MAC address, if any MAC address tries the false key many of time than the IDS will
identify the MAC as intruder and inform the system administrator about the intrusion by popping up
a message on the system of the administrator.

Results:

Simulation of the two different scenarios is done by using the Network simulator (NS 2)
and NAM (Network animator). In scenario 1 the node 1 is intruder and the IDS protocols have figure
it out. The intruder is labeled as 2. In scenario 2 node 1 is the sentinel node and it gets connected to
router after authentication.

Results:

The mechanism can detect a false node in the network which is major threat in WSNs.
Result has been evaluated the performance of IDS protocol by using Ad-hoc On Demand Distance
Vector (AODV) Routing Protocol for routing.
Questionnaire Breakoff and Item Nonresponse in Web-Based Questionnaires: Multilevel Analysis of Person-Level and Item Design Factors in a Birth Cohort (Preprint)
Authors: Blumenberg Cauane , Zugna Daniela , Popovic Maja , Pizzi Costanza , Barros Aluisio J D , Richiardi Lorenzo
Published: December 2018

BACKGROUND

Web-based questionnaires are increasingly used in epidemiologic studies, as traditional methods are facing a decrease in response rates and an increase in costs. However, few studies have investigated factors related to the level of completion of internet-based epidemiologic questionnaires.

OBJECTIVE

Our objective was to identify person-level characteristics and item design factors associated with breakoff (not finishing the questionnaire) and item nonresponse in a Web-based questionnaire.

METHODS

This study was a cross-sectional analysis of the baseline questionnaire, applied from 2005 to 2016, of the Italian NINFEA (Nascita e Infanzia: gli Effetti dell’Ambiente) birth cohort. The baseline questionnaire was administered to enrolled women, who could register at any time during pregnancy. We used logistic regression to analyze the influence of person-level factors on questionnaire breakoff, and a logistic multilevel model (first level: items of the questionnaire; second level: sections of the questionnaire; third level: study participants) to analyze the influence of person-level and item design factors on item nonresponse. Since the number of applicable items depended on the respondent’s characteristics and breakoff, we used inverse probability weighting to deal with missing by design.

RESULTS

Of 5970 women, 519 (8.69%) did not finish the questionnaire. Older age (adjusted odds ratio 1.40, 95% CI 1.05-1.88), lower educational level (adjusted odds ratio [OR] 1.53, 95% CI 1.23-1.90), and earlier stage of pregnancy (adjusted OR 3.01, 95% CI 2.31-3.92) were positively associated with questionnaire breakoff. Of the 1,062,519 applicable items displayed for the participants, 22,831 were not responded to (overall prevalence of item nonresponse 2.15%). Item nonresponse was positively associated with older age (adjusted OR 1.25, 95% CI 1.14-1.38), being in the first trimester of pregnancy (adjusted OR 1.18, 95% CI 1.06-1.31), and lower educational level (adjusted OR 1.23, 95% CI 1.14-1.33). Dropdown menu items (adjusted OR 1.77, 95% CI 1.56-2.00) and items organized in grids (adjusted OR 1.69, 95% CI 1.49-1.91) were positively associated with item nonresponse.

CONCLUSIONS

It is important to use targeted strategies to keep participants motivated to respond. Item nonresponse in internet-based questionnaires is affected by person-level and item design factors. Some item types should be limited to reduce item nonresponse.
A 9-Step Theory- and Evidence-Based Postgraduate Medical Digital Education Development Model: Empirical Development and Validation (Preprint)
Authors: de Leeuw Robert , Scheele Fedde , Walsh Kieran , Westerman Michiel
Published: December 2018

BACKGROUND

Digital education tools (e-learning, technology-enhanced learning) can be defined as any educational intervention that is electronically mediated. Decveloping and applying such tools and interventions for postgraduate medical professionals who work and learn after graduation can be called postgraduate medical digital education (PGMDE), which is increasingly being used and evaluated. However, evaluation has focused mainly on reaching the learning goals and little on the design. Design models for digital education (instructional design models) help educators create a digital education curriculum, but none have been aimed at PGMDE. Studies show the need for efficient, motivating, useful, and satisfactory digital education.

OBJECTIVE

Our objective was (1) to create an empirical instructional design model for PGMDE founded in evidence and theory, with postgraduate medical professionals who work and learn after graduation as the target audience, and (2) to compare our model with existing models used to evaluate and create PGMDE.

METHODS

Previously we performed an integrative literature review, focus group discussions, and a Delphi procedure to determine which building blocks for such a model would be relevant according to experts and users. This resulted in 37 relevant items. We then used those 37 items and arranged them into chronological steps. After we created the initial 9-step plan, we compared these steps with other models reported in the literature.

RESULTS

The final 9 steps were (1) describe who, why, what, (2) select educational strategies, (3) translate to the real world, (4) choose the technology, (5) complete the team, (6) plan the budget, (7) plan the timing and timeline, (8) implement the project, and (9) evaluate continuously. On comparing this 9-step model with other models, we found that no other was as complete, nor were any of the other models aimed at PGMDE.

CONCLUSIONS

Our 9-step model is the first, to our knowledge, to be based on evidence and theory building blocks aimed at PGMDE. We have described a complete set of evidence-based steps, expanding a 3-domain model (motivate, learn, and apply) to an instructional design model that can help every educator in creating efficient, motivating, useful, and satisfactory PGMDE. Although certain steps are more robust and have a deeper theoretical background in current research (such as education), others (such as budget) have been barely touched upon and should be investigated more thoroughly in order that proper guidelines may also be provided for them.
Medical Conditions Predictive of Self-Reported Poor Health: Retrospective Cohort Study (Preprint)
Authors: Cepeda M Soledad , Reps Jenna , Kern David M , Stang Paul
Published: December 2018

BACKGROUND

Identifying the medical conditions that are associated with poor health is crucial to prioritize decisions for future research and organizing care. However, assessing the burden of disease in the general population is complex, lengthy, and expensive. Claims databases that include self-reported health status can be used to assess the impact of medical conditions on the health in a population.

OBJECTIVE

This study aimed to identify medical conditions that are highly predictive of poor health status using claims databases.

METHODS

To determine the medical conditions most highly predictive of poor health status, we used a retrospective cohort study using 2 US claims databases. Subjects were commercially insured patients. Health status was measured using a self-report health status response. All medical conditions were included in a least absolute shrinkage and selection operator regression model to assess which conditions were associated with poor versus excellent health.

RESULTS

A total of 1,186,871 subjects were included; 61.64% (731,587/1,186,871) reported having excellent or very good health. The leading medical conditions associated with poor health were cancer-related conditions, demyelinating disorders, diabetes, diabetic complications, psychiatric illnesses (mood disorders and schizophrenia), sleep disorders, seizures, male reproductive tract infections, chronic obstructive pulmonary disease, cardiomyopathy, dementia, and headaches.

CONCLUSIONS

Understanding the impact of disease in a commercially insured population is critical to identify subjects who may be at risk for reduced productivity and job loss. Claims database studies can measure the impact of medical conditions on the health status in a population and to assess changes overtime and could limit the need to collect prospective collection of information, which is slow and expensive, to assess disease burden. Leading medical conditions associated with poor health in a commercially insured population were the ones associated with high burden of disease such as cancer-related conditions, demyelinating disorders, diabetes, diabetic complications, psychiatric illnesses (mood disorders and schizophrenia), infections, chronic obstructive pulmonary disease, cardiomyopathy, and dementia. However, sleep disorders, seizures, male reproductive tract infections, and headaches were also part of the leading medical conditions associated with poor health that had not been identified before as being associated with poor health and deserve more attention.
Вплив сагітального попереково-тазового балансу на результати оперативного лікування гриж міжхребцевих дисків у людей старшої вікової категорії
Authors: Piontkovskyi V.K.
Published: December 2018

Проведено аналіз результатів хірургічного лікування гриж міжхребцевих дисків поперекового відділу хребта у 78 людей старшої вікової категорії з різними показниками попереково-тазового балансу. Виявлено тісний взаємозв’язок між попереково-тазовими параметрами: рelvic incidens (PI) — величиною нахилу таза, sacral slop (SS) — величиною нахилу верхньої поверхні S1 та global lumbar lordosis (GLL) — величиною глобального поперекового лордозу — та результатами хірургічного лікування гриж міжхребцевих дисків поперекового відділу хребта. Зменшення параметрів PI, SS і GLL сприяє збільшенню навантаження на передній опорний комплекс, що призводить до збільшення кількості рецидивів гриж та появи гриж у суміжних сегментах. Збільшення параметрів PI, SS і GLL веде до перевантаження заднього опорного комплексу, що клінічно проявляється процесами гіпертрофії фасеток і явищами стенозування.
Клінічно-організаційні особливості надання травматологічної допомоги пораненим із дефектами м’яких тканин при вогнепальних та мінно-вибухових ушкодженнях кінцівок
Authors: Khomenko I.P. , Korol S.O. , Korol S.O. , Matviichuk B.V. , Matviichuk B.V.
Published: December 2018

Мета дослідження: покращити результати надання травматологічної допомоги пораненим із дефектами м’яких тканин на основі впровадження диференційованої хірургічної тактики закриття ран на етапах медичної евакуації (ЕМЕ). Матеріали та методи. Загальний масив дослідження становили 2051 поранений з осколковими, кульовими та мінно­вибуховими ушкодженнями кінцівок, що трапилися з квітня 2014 р. по вереснь 2016 р. Визначення хірургічної тактики закриття дефектів м’яких тканин здійснювали на основі метричної класифікації з урахуванням площі, обсягу й анатомічних зон ушкодження. Результати. Поєднання метричних характеристик ранових дефектів за площею, обсягом із локалізацією поранень в єдину класифікацію дозволило запропонувати комплексний підхід до сортування поранених на ЕМЕ і визначити подальшу хірургічну тактику закриття дефектів м’яких тканин. Відповідно до сортувально­евакуаційного призначення поранених із вогнепальними ушкодженнями стопи та кисті (третя зона ушкодження) лікували в спеціалізованих центрах ІІІ та IV рівнів. При середніх та великих ранах стегна, гомілки, плеча та передпліччя медичну допомогу надавали на ЕМЕ ІІ та ІІІ рівнів, при великих та надвеликих ранах означеної локалізації — в спеціалізованих клініках IV рівня. Висновки. Впровдження диференційованої хірургічної тактики в поранених із дефектами м’яких тканин дозволило покращити функціональні результати: збільшити питому вагу добрих — з 46,9 до 53,7 %, зменшити відносну кількість незадовільних — з 18,8 до 11,6 %.
Клиническое и клиповое мышление в процессе обучения врачей-интернов
Authors: Кlygunenko O.M. , Yekhalov V.V. , Кravets О.V. , Kusch K.O. , Sedinkin V.A.
Published: December 2018

Клиповое мышление — это ответ на повышение объема сведений. По результатам тестовой методики, проведенной среди врачей-интернов различных специальностей, мы не отмечали статистически достоверной зависимости диагностированного клипового мышления от бюджетной или контрактной формы обучения. Категория длительного мышления у интернов, ­обучающихся на бюджетной основе, вдвое превышала этот показатель в контрактной группе. Клиповое мышление в системе медицинского образования оттесняет клиническое, а также принципы медицинской деонтологии, способствует развитию фельдшеризма и т.п. Современное медицинское образование требует формирования качественно нового подхода к учебному процессу, основанному на формировании и развитии клинического мышления, с учетом психологических особенностей современной молодежи. На современном этапе развития образования в Украине тестовый контроль интенсивно развивается и распространяется, а использование тестовых технологий занимает особое место в разработке и внедрении в учебный процесс новых подходов к оценке достижений студентов и выявлению уровня знаний. Невозможность для студента систематизировать полученные знания с каждым годом вызывает все больше недовольства и ведет к снижению профессиональной подготовки. Применение тестов в образовании снижает критические, аналитические возможности студентов, опять-таки заставляя улавливать лишь фрагменты того или иного явления, без выяснения его причин, закономерностей, без построения логических схем. В связи с вышеизложенным мы видим необходимость создания альтернативных образовательных программ, изменения структуры предоставления информации, перевода учебников в цифровую форму с многоуровневой структурой.
Исследование медико-социальных и организационных аспектов предоставления экстренной медицинской помощи населению Харьковского региона
Authors: Fedak B.S. , Zabashta V.F. , Lobova I.O. , Liermontova Yu.O.
Published: December 2018

Актуальность. По данным Всемирной организации здравоохранения, в мире около 20 % людей умирает из-за отсутствия квалифицированной медицинской помощи на догоспитальном этапе, что определяет возрастание роли экстренной медицинской помощи (ЭМП) населению в системе здравоохранения. Именно поэтому обеспечение бесплатной, своевременной и эффективной медицинской помощью населения Украины при состояниях, угрожающих жизни больных, является одной из важнейших задач в сфере здравоохранения страны. Для исполнения положений Закона Украины «Об экстренной медицинской помощи» работа КУЗ «Центр экстренной медицинской помощи и медицины катастроф» (ЦЭМП и МК) Харьковской области в течение 2013–2017 гг. была направлена на улучшение показателей службы ЭМП и повышение ее качества. Цель — анализ динамики основных показателей деятельности службы ЭМП Харьковской области и разработка направлений совершенствования системы ЭМП. Материалы и методы. Проведен анализ отчетной документации учреждения «Центр экстренной медицинской помощи и медицины катастроф» Харьковской области за 2013–2017 гг. В ходе выполнения исследования использованы ретроспективный, статистический и математический методы анализа. Результаты. На сегодняшний день актуальной кадровой проблемой службы ЭМП и МК, вызванной крайне низкой материальной мотивацией, является дефицит работников. Так, согласно результатам проведенного исследования установлено, что показатель укомплектованности врачами в 2017 г. составляет 66,2 % (против 57,8 % в 2013 г.), средним медицинским персоналом — 84,7 % (против 86,0 % в 2013 г.), младшим медицинским персоналом — 73,7 % (против 82,5% в 2013 г.), водителями бригад ЭМП — 71,0 % (против 85,1 % в 2013 г.). За последние 5 лет увеличилось на 44,8 % среднесуточное количество обслуженных лиц бригадами ЭМП. При этом самый высокий уровень нагрузки приходится на врачебную общепрофильную бригаду и составляет 16,9 вызовов, самый низкий — на психиатрическую бригаду (7,7 вызова). В структуре причин вызовов в течение исследуемого периода преобладали выезды на внезапные заболевания (79,3 %) и несчастные случаи, травмы и отравления (10,4 %). При этом показатель своевременного прибытия бригад ЭМП на вызовы в городах составлял 97,8 % от общего количества экстренных вызовов, в условиях сельской местности региона — 98,1 %. Выводы. На основании результатов проведенного исследования авторами выявлены основные проблемы в организации оказания ЭМП населению и предложены основные направления ее совершенствования, что при успешной реализации позволит максимально удовлетворить потребности населения и рационально использовать все виды ресурсов системы здравоохранения.
Обращение главного редактора
Authors: Nikonov V.V.
Published: December 2018

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Tata Kelola Arsip Kantor Desa di Wilayah Kecamatan Sumbang Kabupaten Banyumas dalam Mewujudkan Tertib Arsip Desa
Authors: Abriani Nining , Anggorowati Anis , Wardani Nugraheni Panca
Published: December 2018

Penelitian ini bertujuan untuk mengetahui bagaimana tata kelola arsip dalam mendukung pelayanan administrasi pada kantor desa di Kecamatan Sumbang, Kabupaten Banyumas. Penelitian ini menggunakan metode deskriptif dengan data kualitatif. Pengamatan meliputi implementasi proses manajemen kearsipan, dan peran perencanaan, pengorganisasian, pengawasan serta memperhatikan faktor-faktor yang menjadi penentu dalam pelaksanaan pengelolaan arsip yaitu sumber daya manusia, sarana prasarana, anggaran, dukungan dan perhatian pimpinan. Data yang dianalisis adalah hasil observasi dan hasil wawancara dengan kepala desa, sekretaris desa, dan kaur umum (pengelola arsip).Hasil penelitian menunjukkan bahwa tata kelola arsip kantor desa di wilayah Kecamatan Sumbang mengacu pada pola klasifikasi, pedoman pengurusan surat, dan pedoman penataan berkas. Hasil penelitian juga menunjukkan bahwa tata kelola arsip kantor desa di wilayah Kecamatan Sumbang belum sesuai dengan standar kearsipan. Faktor yang sangat menentukan bagi keberhasilan tata kelola arsip pada kantor desa di wilayah Kecamatan Sumbang adalah dukungan perhatian pimpinan dan anggaran, karena tanpa adanya dukungan perhatian dari pimpinan dan anggaran maka kegiatan pengelolaan arsip tidak dapat berjalan dengan optimal, kebutuhan sarana prasarana tidak akan terpenuhi.
O debate Sartre-Lukács revisitado: as polêmicas sobre dialética, classe e alienação
Authors: Gajanigo Paulo
Published: December 2018

Neste artigo, traça-se o histórico do debate entre Sartre e Lukács – presente, principalmente, nas obras Existencialismo ou Marxismo (1948) e Ontologia do Ser Social de Lukács e Crítica da Razão Dialética (1960) de Sartre –, analisando a trajetória de ambos em relação ao marxismo. Em concordância com Lukács, demonstramos como Sartre, apesar da aproximação ao marxismo, não rompeu com o idealismo em Crítica da Razão Dialética ao desconsiderar a dialética da natureza, como fica claro na maneira como define as categorias de alienação e classe. Por fim, apresenta-se uma crítica, sob a inspiração da posição de Sartre de que há um existencialismo progressista, à forma como Lukács caracterizou o existencialismo em 1948. Afirma-se, no entanto, que o próprio Lukács, em seus últimos textos, deu elementos para superar sua posição anterior, ao criticar de maneira profunda o stalinismo e a visão de dialética da natureza de Engels.
Desafios Contemporâneos da Teoria Crítica: As novas (bio)tecnologias e o remodelamento da base material da sociedade
Authors: Rotondaro Tatiana Gomes
Published: December 2018

Somos diariamente submetidos à informações, veiculadas pela mídia e por periódicos especializados, que reforçam a ideia de que os nossos genes são responsáveis pelas nossas ações e comportamentos. Mas se a compreensão dos condicionantes da ação humana é um dos principais problemas sociológicos, torna-se pertinente indagarmos por que essa tese determinista possui tanto apelo na opinião pública.  U melhor dizendo, por que as ciências sociais, ao menos aparentemente, têm publicamente perdido a sua autoridade acadêmica para explicar os condicionantes da ação humana para biólogos e psicólogos evolucionistas, que se apoiam em explicações genéticas altamente deterministas? Trabalhando nos marcos da Teoria Crítica, e olhando para essa questão a partir das (bio)tecnologias, argumentarei que essas novas tecnologias são atores privilegiados de uma transformação orgânico-material histórica, e que parte da fragilidade sociológica em lidar com esta especificidade se deve ao próprio desdobramento epistemológico apresentado pela disciplina nas últimas décadas.
Assédio sexual: O poder do macho dentro da universidade
Authors: De Sá Bianca Schimdt , Folriani Maycon Douglas , Rampazo Adriana Vinholi
Published: December 2018

Na presente pesquisa buscou-se analisar os aspectos da experiência do assédio sexual vivenciadas por alunas dentro da universidade durante suas graduações, tomando como base a questão da relação de poder da hierarquia de gênero socialmente construída. Com isto, constatou-se que, em todos os casos, as entrevistadas sofreram algum tipo de assédio sexual dentro da universidade e que esta ação não partiu apenas de seus colegas, mas também de seus professores, indicando forte presença dessa hierarquização de gênero socialmente construída.
Programa Mulher, Viver Sem Violência: Uma Análise de sua Implementação a Partir da Casa da Mulher Brasileira e de Entidades Parceiras
Authors: Andrada Marques Elissa Emily , De Almeida Midlej e Silva Suylan
Published: December 2018

O objetivo desta pesquisa foi investigar de que forma as ações do Programa Mulher, Viver sem Violência têm sido implementadas em Brasília, Distrito Federal, por meio da Casa da Mulher Brasileira em interface com outras organizações que também fazem atendimento às mulheres vítimas de violência. A pesquisa utilizou como base teórica os conceitos de Políticas de Gênero, Implementação de Políticas Públicas e Relações Interorganizacionais. O estudo é uma análise qualitativa, utilizando como procedimentos metodológicos pesquisa documental, observação participante e entrevistas individuais semiestruturadas. Por meio dos resultados da pesquisa, foi possível perceber que a Casa da Mulher Brasileira realiza diversas ações em conjunto com outros órgãos para atingir os seus objetivos visando a implementação do Programa. Apesar de existirem alguns problemas nas relações com os órgãos, percebeu-se que o propósito de atender as mulheres vítimas de violência está sendo cumprido, e os órgãos estão encaminhando essas mulheres de maneira integrada.
''O gado sempre vai ao cocho'': vínculos e tensões na dialética sujeito-lugar em "Lavoura arcaica" / “The cattle always go trough”: attachments and tensions in the subject-place dialetics at “Ancient tillage”
Authors: Souza Júnior Carlos Roberto Bernardes de , Almeida Maria Geralda
Published: December 2018

Configurada como obra outsider ao período em que foi lançada, 1975, “Lavoura Arcaica” de Raduan Nassar discute questões concernentes aos arcaicos conflitos humanos no âmbito do lar. Em confronto ao patriarcado do lar, o pathos subversivo de André ocasiona em rupturas no lugar. Pelos vínculos de ancestralidade, paixão, corporeidade e natureza, André evidencia relações que desdobram um cotidiano familiar. O artigo centra-se na interpretação da inseparabilidade de pessoas-ou-pessoa-experienciando-lugar, correlacionando a dialética sujeito-lugar. Entremeado pelo corpo, as forças desejantes dos sujeitos se contrapõem na proposição de outras formas e substancializações de lugar. Destarte, identifica-se que as tensões e vínculos manifestam-se como maneiras de viver e reconstituir o lugar formulado no seio do habitar.
Audit Kepatuhan Syariah Melalui Peran Dewan Pengawas Syariah Pada PT. BPRS Dana Mulia Surakarta
Authors: Fatmawati Diah Ayu , Usnan Usnan
Published: December 2018

The aim of this study is to find out how the shariah compli- ance audit is carried out through the role of the sharia supervisory board (DPS) at PT. BPRS Dana Mulia Surakarta. This study is us- ing a qualitative approach, where the data in this study were obtained through interview, documentation and observation techniques related to the implementation of sharia compliance audits through the role of DPS in BPRS Dana Mulia Surakarta, which then obtained data analyzed descriptively.
The results showed that the shariah compliance audit was im- plemented through the role of the sharia supervisory board (DPS) at PT. BPRS Dana Mulia Surakarta, it’s just that the implementation of the role of DPS in the BPRS under study is still not optimal, among others: (1) The role of DPS as a supervisor is still not optimal consid- ering there are still several products at PT. BPRS Dana Mulia Sura- karta which has not fulfilled the sharia principles. (2) The role of DPS as Advisor still needs to be improved because all this time the Sharia Supervisory Board (DPS) is only limited to providing advice from the findings of the work and providing studies to employees without any deeper follow up.
Keywords: Shariah Compliance Audit and DPS
JEL Classification: G21, G28,M38, M42
Quantifying of the relationship between novel intermittent drying variables and some quality properties of parboiled rice using response surface methodology
Authors: Rasooli Sharabiani , Taghinezhad Ebrahim
Published: December 2018

In this research, the effects of intermittent drying variables on some quality properties of parboiled rice were investigated, then a mathematical model was applied to predict the value of quality features non-destructively using response surface methodology (RSM). The intermittent drying variables consisted of hot air temperature (40, 50 and 60?C), radiation intensity (0.21, 0.31 and 0.41 W/cm2) and microwave power (100, 200 and 300 W). The intermittent drying was performed at two stages with a tempering time between drying steps using a hybrid drying of hot air?infrared radiation and microwave drying at the first stage and second stage, respectively. According to RSM results, the effect of drying variables on the quality properties of parboiled rice were significant (p < 0.01). Also, the best mathematical model for prediction of quality properties of samples was the quadratic equation (R2 = 0.96-0.98). The HRY (61.8-73.2%), hardness (118.63-215.27 N) and color value (17.28-19.22) increased, while the lightness (64.17-59.51) decreased during drying. RSM can be able to predict the optimization parameters for the best quality properties (i.e., HRY = 72.42%, lightness = 59.47, color value = 19.25 and hardness = 213.91 N) based on temperature of 60?C, radiation of 0.41 W/cm2 and power of 300 W.
An augmented reality system for improving health and safety in the electro-energetics industry
Authors: Tatic Dusan
Published: December 2018

Occupational safety has a crucial role in every technological process in
industry environments. Recently, smart mobile devices have become standard
hardware that can help inform workers about their duties and procedures
during work. In this paper, we present an augmented reality (AR) system for
mobile devices as a tool for safeguarding health and safety, and the secure
performance of tasks in a technological process by following virtual
instructions in the workplace. In a case study, we explored the task
procedures and defined the risk factors in the electro-energetics industry.
Based on that, we implement a corresponding AR system that should be used to
issue occupational safety and work instructions to workers during task
execution. With that aim in mind, we designed a client-server architecture to
project the related instructions on the screen of the mobile device, to
ensure the confirmation of implementing them, as well as to keep a record of
all the steps the worker performed. As an illustrative example, we present
the application of the designed AR system to particular tasks in
electro-energetics industrial plants.
The Outcome Effect and Professional Skepticism
Authors: Brazel Joseph F.
Published: December 2018

Despite the importance placed on professional skepticism by the accounting profession and regulators, the failure of auditors to exercise an appropriate level of skepticism continues to be a global issue. This article summarizes a recent study by Brazel, Jackson, Schaefer, and Stewart (2016) that examines a potential barrier to skepticism: that outcome knowledge biases supervisors' evaluations of skeptical behavior. Holding a staff member's skeptical judgments and acts constant, Brazel et al. (2016) find that superiors on engagement teams evaluate the staff's skeptical behavior based on whether the staff's investigation of an issue ultimately identifies a misstatement. The evidence suggests that evaluators penalize auditors who employ an appropriate level of skepticism, but do not identify a misstatement. Collectively, Brazel et al. (2016) depict an evaluation system that may inadvertently discourage skepticism amongst auditors in the field.
Organizational and infrastructural solutions in creating competitive advantage of sustainable urban transport – Gdańsk case study
Authors: Chaberek-Karwacka Grażyna
Published: December 2018

The paper presents conclusions of the survey conducted in Gdańsk in October 2017. The study aimed to compare travel times between the largest residential districts in Gdańsk and the area of the business-academic center. The research was aimed at showing time losses on the commuting trips and their organizational and infrastructural causes, which lead to the extension of the actual travel time. Based on the identified time losses and their causes, recommendations regarding further organizational and investment work were presented to improve the competitiveness of public urban transport and bicycles in relation to the cars.
Keragaan Daya Hasil dan Morfologi Umbi Klon-Klon Ubijalar (Ipomoea batatas) Berkadar Antosianin Tinggi
Authors: Restuono Joko
Published: December 2018

Selain sebagai sumber bahan pangan, ubijalar juga sebagai bahan industri karena kaya karbohidrat, vitamin A dan C, antosianin dan mineral. Ubijalar dengan kandungan antosianin tinggi diperlukan dalam industri oleh karena itu perlu dilakukan penyaringan klon-klon unggul. Tujuan dari penelitian ini adalah untuk mengetahui keragaan dan morfologi umbi klon-klon terpilih ubijalar yang berproduksi dan mengandung antosianin tinggi sebagai bahan tahapan penyaringan berikutnya. Penelitian dilaksanakan ditanah sawah petani Desa Rogojampi, Kecamatan Genteng, Kabupaten Banyuwangi pada MK II 2013. Rancangan yang digunakan adalah acak kelompok dengan tiga ulangan dengan perlakuan 40 klon ubijalar terdiri dari 37 klon uji yang berkadar antosianin tinggi dan tiga klon/varietas pembanding. Hasil penelitian menunjukkan kisaran hasil umbi adalah 15,5 - 35,8 t/ha. Terdapat 11 klon uji yang memberikan hasil umbi lebih dari 30,0 t/ha.dari hasil ini juga lebih tinggi dari kedua pembanding (Antin 1 dan Antin 2). Kesebelas klon uji tersebut diamati secara visual memiliki kadar antosianin antara 60-150 mg/100g.
Efektifitas Beberapa Paket Pupuk dan Umur Panen Buah Terhadap Produksi dan Mutu Benih Melon (Cucumis melo L.)
Authors: Yanuarta Daniar Eki , Bintoro Mochamat , Sulistyono Nantil Bambang Eko
Published: December 2018

Pada tahun 2013 produksi melon nasional mengalami penurunan hasil. Salah satu upaya untuk meningkatkan produksi benih melon adalah dengan memperhatikan kultur teknisnya. Penelitian ini dilaksanakan pada bulan Agustus sampai November 2016 di Desa Suco, Kecamatan Mumbulsari dan laboratorium PT Benih Citra Asia, Jl. Akmaludin 26, Kecamatan Ajung, Kabupaten Jember dengan menggunakan Rancangan Acak Kelompok (RAK) faktorial. Faktor pertama adalah Paket Pupuk Pertama (Organik 1000 gr, ZA 15 gr, SP-36 30 gr, KCL 15 gr, NPK 20 gr) per tanaman dan Paket Pupuk Kedua (Organik 1000 gr, ZA 40 gr, SP-36 60 gr, KCL 38 gr, NPK 12 gr) per tanaman. Faktor kedua adalah Umur panen (30,35,40) hari setelah polinasi. Hasil yang didapat menunjukkan bahwa paket pupuk kedua memberikan pengaruh sangat nyata (**)Â terhadap pertambahan tinggi tanaman umur 14-28 HST, yaitu 89,80 cm, umur 28-42 HST, yaitu 174,31 cm dan jumlah buah dengan rerata tertinggi, yaitu 3,56 kg. Faktor kedua menunjukkan bahwa perlakuan umur panen 30 hari setelah polinasi memberikan pengaruh berbeda sangat nyata (**) terhadap jumlah benih bernas dengan rerata tertinggi, yaitu 876,52 gr dan berat benih bernas dengan rerata tertinggi, yaitu 13,11 gr. Interaksi antara perlakuan paket pupuk dan umur panen tidak memberikan pengaruh terhadap semua semua parameter.
The Association Between Changes in Weekly Running Distance and Running–Related Injury: Preparing for a Half Marathon
Authors: Damsted Camma , Parner Erik Thorlund , Sørensen Henrik , Malisoux Laurent , Hulme Adam , Nielsen Rasmus Østergaard
Published: December 2018

Background

Sudden changes in training load may play a key role in the development of running-related injury (RRI). Because the injury mechanism depends on the runner's musculoskeletal load capacity, the running schedule followed prior to sudden change in training load may influence the amount of change that a runner can tolerate before the runner is at a higher risk of RRI.

Objectives

To investigate the association between change in weekly running distance and RRI, and to examine whether the association may be modified by the running schedule the runner follows.

Methods

Two hundred sixty-one healthy (noninjured) runners were included in this prospective cohort study over a period of 14 weeks. Data on running activity were collected daily and objectively, using a global positioning system watch or smartphone. Instances of RRIs were collected using weekly e-mailed questionnaires. Primary exposure was defined as changes in weekly running distance. Data were analyzed with time-to-event models that produced cumulative risk difference as the measure of association.

Results

A total of 56 participants (21.5%) sustained an RRI during the 14-week study period. Twenty-one days into the study period, significantly more runners were injured when they increased their weekly running distance by 20% to 60% compared with those who increased their distance by less than 20% (risk difference, 22.6%; 95% confidence interval: 0.9%, 44.3%; P = .041). No significant difference was found after 56 and 98 days. No significant effect-measure modification by running schedule was found.

Conclusion

Significantly more runners were injured 21 days into the study period when they increased their weekly running distances by 20% to 60% compared with those who increased their distances by less than 20%.

Level of Evidence

Prognosis, level 1b. J Orthop Sports Phys Ther 2019;49(4):230–238. Epub 7 Dec 2018. doi:10.2519/jospt.2019.8541