bluuebunny/crossref_metadata_2025 huggingface dataset:
Photodegradation of Unmodified and Thermally Modified Wood Due to Indoor Lighting
Authors: Cirule Dace , Kuka Edgars , Kevers Matiss , Andersone Ingeborga , Andersons Bruno
Published: August 2021

Considering interior applications, sunlight, both direct through open window and through window glass, and artificial lighting are the main sources of radiation possessing sufficient energy to trigger photodegradation processes in wood. LED lamps, which emit mostly visible light, are becoming the dominant artificial light source in various interiors. In the present study, photodegradation of thermally modified (TM) and unmodified (UM) ash (Fraxinus excelsior), aspen (Populus tremula), and pine (Pinus sylvestris) due to exposure to UV radiation and LED lamps was evaluated and compared by analysing wood discolouration (CIELAB colour space), changes in reflectance and FTIR spectra, and formation of water-soluble components. The results show that, apart from UV radiation, LED lamps may cause considerable photodegradation of both TM and UM wood resulting in visually perceptible colour change, alteration in chemical structure and formation of water-soluble components. Improved photo-stability was observed for TM wood exposed to UV radiation, while even more changes in FTIR spectra were detected for TM than UM wood in the experiment with LED lamps. Comparing TM and UM wood, the changes due to photodegradation were quite similar for TM wood of all species while significant differences were observed in the case of UM wood.
Spline Collocation for Multi-Term Fractional Integro-Differential Equations with Weakly Singular Kernels
Authors: Pedas Arvet , Vikerpuur Mikk
Published: August 2021

We consider general linear multi-term Caputo fractional integro-differential equations with weakly singular kernels subject to local or non-local boundary conditions. Using an integral equation reformulation of the proposed problem, we first study the existence, uniqueness and regularity of the exact solution. Based on the obtained regularity properties and spline collocation techniques, the numerical solution of the problem is discussed. Optimal global convergence estimates are derived and a superconvergence result for a special choice of grid and collocation parameters is given. A numerical illustration is also presented.
From Nano-Gels to Marine Snow: A Synthesis of Gel Formation Processes and Modeling Efforts Involved with Particle Flux in the Ocean
Authors: Quigg Antonietta , Santschi Peter H. , Burd Adrian , Chin Wei-Chun , Kamalanathan Manoj , Xu Chen , Ziervogel Kai
Published: August 2021

Marine gels (nano-, micro-, macro-) and marine snow play important roles in regulating global and basin-scale ocean biogeochemical cycling. Exopolymeric substances (EPS) including transparent exopolymer particles (TEP) that form from nano-gel precursors are abundant materials in the ocean, accounting for an estimated 700 Gt of carbon in seawater. This supports local microbial communities that play a critical role in the cycling of carbon and other macro- and micro-elements in the ocean. Recent studies have furthered our understanding of the formation and properties of these materials, but the relationship between the microbial polymers released into the ocean and marine snow remains unclear. Recent studies suggest developing a (relatively) simple model that is tractable and related to the available data will enable us to step forward into new research by following marine snow formation under different conditions. In this review, we synthesize the chemical and physical processes. We emphasize where these connections may lead to a predictive, mechanistic understanding of the role of gels in marine snow formation and the biogeochemical functioning of the ocean.
Genetic Resources and Vulnerabilities of Major Cucurbit Crops
Authors: Grumet Rebecca , McCreight James D. , McGregor Cecilia , Weng Yiqun , Mazourek Michael , Reitsma Kathleen , Labate Joanne , Davis Angela , Fei Zhangjun
Published: August 2021

The Cucurbitaceae family provides numerous important crops including watermelons (Citrullus lanatus), melons (Cucumis melo), cucumbers (Cucumis sativus), and pumpkins and squashes (Cucurbita spp.). Centers of domestication in Africa, Asia, and the Americas were followed by distribution throughout the world and the evolution of secondary centers of diversity. Each of these crops is challenged by multiple fungal, oomycete, bacterial, and viral diseases and insects that vector disease and cause feeding damage. Cultivated varieties are constrained by market demands, the necessity for climatic adaptations, domestication bottlenecks, and in most cases, limited capacity for interspecific hybridization, creating narrow genetic bases for crop improvement. This analysis of crop vulnerabilities examines the four major cucurbit crops, their uses, challenges, and genetic resources. ex situ germplasm banks, the primary strategy to preserve genetic diversity, have been extensively utilized by cucurbit breeders, especially for resistances to biotic and abiotic stresses. Recent genomic efforts have documented genetic diversity, population structure, and genetic relationships among accessions within collections. Collection size and accessibility are impacted by historical collections, current ability to collect, and ability to store and maintain collections. The biology of cucurbits, with insect-pollinated, outcrossing plants, and large, spreading vines, pose additional challenges for regeneration and maintenance. Our ability to address ongoing and future cucurbit crop vulnerabilities will require a combination of investment, agricultural, and conservation policies, and technological advances to facilitate collection, preservation, and access to critical Cucurbitaceae diversity.
Landslide Inventory along a National Highway Corridor in the Hissar-Allay Mountains, Central Tajikistan
Authors: Ubaidulloev Akmal , Kaiheng Hu , Rustamov Manuchekhr , Kurbanova Makhvash
Published: August 2021

An increasing amount of landslides leading to significant human and economic consequences is a primary concern for the government of Tajikistan and local authorities. Based on the Committee on Emergency Situations data, from 1996 to 2018, there were 3460 emergencies and more than 1000 fatalities because of earthquake-triggered and rainfall-induced landslides in the region. In addition, landslides caused severe damage to houses and infrastructure facilities due to the population’s lack of landslide hazard knowledge. Therefore, current research focuses on developing a regional-scale landslide inventory map in the Hissar–Allay region, central Tajikistan, where the population density is much higher than at other mountainous territories. In recent decades, the enhancements in geographic information systems, the open access to high-resolution remote sensing data, and an extensive field survey allowed us to identify 922 landslides possible along the highway corridor in the Hissar–Allay region. Based on Varnes’s system, these landslides are classified into four categories: debris flows, rockfalls, shallow landslides, and complex (deep-seated) landslides, considering landslides morphology, geology, deformation of slopes, degree and aspect of slopes, and weathered and disintegrated zones on slopes in the study area. The results show that 8.24% of the total study area is affected by landslides. Along the highway corridor in the Hissar–Allay region there are 96 bodies of deep-seated landslides and 216 rockfall catchments, 273 debris flow catchments, and 313 shallow landslides. Thus, shallow landslides are the most frequent type of movement. In addition, landslide frequency-area distribution analysis shows that shallow landslides are frequent with an area of 1.88E+04 m2; most frequent debris flow channels have a place of 5.58E+05 m2; rockfalls, for its part, are rife with an area of 1.50E+05 m2, and frequent complex landslides have an area of 4.70E+06 m2. Furthermore, it was found out that slopes consist of Silurian formation comprise shales, pebbles, sands, loams, and limestones, metamorphic clays are exposed to landslides more than other geological formations because of the layered structure and their broad spatial distribution in the study area. As the first applied research to compile a landslide inventory map in the Hissar–Allay region on the regional scale, our study provides a sound basis for future explorations of landslide susceptibility, hazard, and risk assessment for this region.
Common Risk Factors in Relatives and Spouses of Patients with Type 2 Diabetes in Developing Prediabetes
Authors: Hsu Wei-Hao , Tseng Chin-Wei , Huang Yu-Ting , Liang Ching-Chao , Lee Mei-Yueh , Chen Szu-Chia
Published: August 2021

Prediabetes should be viewed as an increased risk for diabetes and cardiovascular disease. In this study, we investigated its prevalence among the relatives and spouses of patients with type 2 diabetes or risk factors for prediabetes, insulin resistance, and β-cell function. A total of 175 individuals were included and stratified into three groups: controls, and relatives and spouses of type 2 diabetic patients. We compared clinical characteristics consisting of a homeostatic model assessment for insulin resistance (HOMA-IR) and beta cell function (HOMA-β), a quantitative insulin sensitivity check index (QUICKI), and triglyceride glucose (TyG) index. After a multivariable linear regression analysis, the relative group was independently correlated with high fasting glucose, a high TyG index, and low β-cell function; the relatives and spouses were independently associated with a low QUICKI. The relatives and spouses equally had a higher prevalence of prediabetes. These study also indicated that the relatives had multiple factors predicting the development of diabetes mellitus, and that the spouses may share a number of common environmental factors associated with low insulin sensitivity.
Evaluation of and Intervention for Sarcopenia in Hepatology Departments: A Survey of Nurses in Japan
Authors: Ohashi Kazuki , Ito Madoka , Kawakubo Megumi , Sato Ikue
Published: August 2021

Sarcopenia is associated with poor prognosis and decreased quality of life in patients with chronic liver disease (CLD). The present study aimed to clarify the dissemination of interventions such as evaluations, prevention efforts, and treatments for sarcopenia among patients in hepatology outpatient departments and wards in Japan, as well as examine the factors related to such dissemination. A cross-sectional study was performed involving nurses from hospitals accredited by the Japan Society of Hepatology. Participants completed a questionnaire regarding evaluations and interventions for sarcopenia in their department. Nurses from 72 outpatient departments and 162 wards provided responses to the questionnaire. Overall, 37.9% of outpatient departments and 37.6% of wards performed evaluations or interventions for sarcopenia. Outpatient departments and wards that evaluated sarcopenia or intervened held more workshops or training regarding sarcopenia than departments and wards that did not (outpatient departments: 52.0% vs. 12.2%, wards: 32.1% vs. 12.9%). Holding workshops or training regarding sarcopenia (outpatient departments; OR = 7.51, 95% confidence interval (CI): 2.12–26.6, wards; OR = 2.61, 95% CI: 1.11–6.15) was significantly associated with dissemination practices. These findings suggest that expanding knowledge of sarcopenia and developing practical skills among general nurses may aid in preventing sarcopenia among patients with CLD.
Impact of Climate Change on the Streamflow Modulated by Changes in Precipitation and Temperature in the North Latitude Watershed of Nepal
Authors: Maharjan Manisha , Aryal Anil , Talchabhadel Rocky , Thapa Bhesh Raj
Published: August 2021

It is unambiguous that climate change alters the intensity and frequency of precipitation and temperature distribution at the global and local levels. The rate of change in temperature in the northern latitudes is higher than the worldwide average. The annual distribution of precipitation over the Himalayas in the northern latitudes shows substantial spatial and temporal heterogeneity. Precipitation and temperature are the major driving factors that impact the streamflow and water availability in the basin, illustrating the importance of research on the impact of climate change on streamflow by varying the precipitation and temperature in the Thuli Bheri River Basin (TBRB). Multiple climate models were used to project and evaluate the precipitation and temperature distribution changes in temporal and spatial domains. To analyze the potential impact of climate change on the streamflow in the basin, the Soil and Water Assessment Tool (SWAT) hydrological model was used. The climate projection was carried out in three future time windows. The result shows that the precipitation fluctuates between approximately +12% and +50%, the maximum temperature varies between −7% and +7%, and the minimum temperature rises from +0.7% to +5% in intermediate- and high-emission scenarios. In contrast, the streamflow in the basin varies from −40% to +85%. Thus, there is a significant trend in the temperature increase and precipitation reduction in the basin. Further, the relationship between precipitation and temperature with streamflow shows a substantial dependency between them. The variability in precipitation and streamflow is successfully represented by the water yield in the basin, which plays an important role in the sustainability of the water-related projects in the basin and downstream to it. This also helps quantify the amount of water available for hydropower generation, agricultural production, and the water ecosystem in the TBRB.
Immunomodulatory Drugs for the Treatment of B Cell Malignancies
Authors: Ioannou Nikolaos , Jain Khushi , Ramsay Alan G.
Published: August 2021

Accumulating evidence suggests that the tumor microenvironment (TME) is involved in disease progression and drug resistance in B cell malignancies, by supporting tumor growth and facilitating the ability of malignant cells to avoid immune recognition. Immunomodulatory drugs (IMiDs) such as lenalidomide have some direct anti-tumor activity, but critically also target various cellular compartments of the TME including T cells, NK cells, and stromal cells, which interfere with pro-tumor signaling while activating anti-tumor immune responses. Lenalidomide has delivered favorable clinical outcomes as a single-agent, and in combination therapy leads to durable responses in chronic lymphocytic leukemia (CLL) and several non-Hodgkin lymphomas (NHLs) including follicular lymphoma (FL), diffuse large B cell lymphoma (DLBCL), and mantle cell lymphoma (MCL). Recently, avadomide, a next generation cereblon E3 ligase modulator (CELMoD), has shown potent anti-tumor and TME immunomodulatory effects, as well as promising clinical efficacy in DLBCL. This review describes how the pleiotropic effects of IMiDs and CELMoDs could make them excellent candidates for combination therapy in the immuno-oncology era—a concept supported by preclinical data, as well as the recent approval of lenalidomide in combination with rituximab for the treatment of relapsed/refractory (R/R) FL.
Beach Monitoring and Morphological Response in the Presence of Coastal Defense Strategies at Riccione (Italy)
Authors: Romagnoli Claudia , Sistilli Flavia , Cantelli Luigi , Aguzzi Margherita , De Nigris Nunzio , Morelli Maurizio , Gaeta Maria Gabriella , Archetti Renata
Published: August 2021

The coastal area at Riccione, in the southern Emilia-Romagna littoral region, is exposed to erosive processes, which are expected to be enhanced by climate change. The beach, mostly composed of fine sand, is maintained through various defense strategies, including frequent nourishment interventions for balancing the sediment deficit and other experimental solutions for reducing coastal erosion. Artificial reshaping of the beach and “common practices” in the sediment management redefine the beach morphology and the sediment redistribution almost continuously. These activities overlap each other and with the coastal dynamics, and this makes it very difficult to evaluate their effectiveness, as well as the role of natural processes on the beach morphological evolution. Topo-bathymetric and sedimentological monitoring of the beach has been carried out on a regular basis since 2000 by the Regional Agency for Prevention, Environment and Energy of Emilia-Romagna (Arpae). Further monitoring of the emerged and submerged beach has been carried out in 2019–2021 in the framework of the research project STIMARE, focusing on innovative strategies for coastal monitoring in relation with erosion risk. The aim of this study is to assess the coastal behavior at the interannual/seasonal scale in the southern coastal stretch of Riccione, where the adopted coastal defense strategies and management actions mostly control the morphological variations in the emerged and submerged beach besides the wave and current regime. The topo-bathymetric variations and erosion/accretion patterns provided by multitemporal monitoring have been related to natural processes and to anthropogenic activities. The morphological variations have been also assessed in volumetric terms in the different subzones of the beach, with the aim of better understanding the onshore/offshore sediment exchange in relation with nourishments and in the presence of protection structures. The effectiveness of the adopted interventions to combat erosion, and to cope with future climate change-related impacts, appears not fully successful in the presence of an overall sediment deficit at the coast. This demonstrates the need for repeated monitoring of the emerged and submerged beach in such a critical setting.
What Speleothems Tell Us about Long-Term Rainfall Oscillation throughout the Holocene on a Planetary Scale
Authors: Pinault Jean-Louis , Pereira Ligia
Published: August 2021

Within the context of anthropogenic warming, rainfall oscillations may induce especially important societal impacts worldwide. In this article, we propose to study potential underlying mechanisms related to precipitation changes on a planetary scale by taking advantage of the recent theory of Rossby waves of long periods winding around subtropical gyres, the Gyral Rossby Waves (GRWs). The stable oxygen isotopic compositions of speleothems are used to regionalize and reconstruct the evolution of long-term rainfall oscillation during the Holocene. The method applied here consists in estimating the wavelet power of dated series of stable oxygen isotopic composition (δ18O) in speleothems within period bands representative of subharmonic modes. Our findings highlight: (1) hydrological processes resulting from friction between the North Equatorial Current (NEC) and the North Equatorial Counter Current (NECC) to explain the weakening of ENSO activity in mid-Holocene, and (2) the quasi-resonance of the equatorward migration of the summer Inter Tropical Convergence Zone (ITCZ) during the Holocene, because of the progressive decrease of the thermal gradient between the low and high latitudes of the gyres. The results of this study suggest that the spatial and temporal variations in the amplitude of the rainfall oscillations are related both on the acceleration/deceleration phases of the western boundary currents and on the shrinkage of the Hadley cell. The latitudinal shift of the summer ITCZ in response to changes in the thermal gradient is of the utmost importance in predicting the expansion of deserts resulting from anthropogenic warming.
Detection of Infectious Hypodermal and Hematopoietic Necrosis Virus (IHHNV, Decapod Penstylhamaparvovirus 1) in Commodity Red Claw Crayfish (Cherax quadricarinatus) Imported into South Korea
Authors: Lee Chorong , Choi Seong-Kyoon , Jeon Hye Jin , Lee Seung Ho , Kim Young Kyoon , Park Song , Park Jin-Kyu , Han Se-Hyeon , Bae Seulgi , Kim Ji Hyung , Han Jee Eun
Published: August 2021

Freshwater crayfish, which are cultivated in aquaculture, are economically important for food and ornamental purposes. However, relatively few studies have focused on potentially pathogenic viruses in crayfish compared to in penaeid shrimp. Commodity red claw crayfish (Cherax quadricarinatus; 400 crayfish in 10 batches) and red swamp crayfish (Procambarus clarkii; 40 crayfish in 2 batches) imported into South Korea from Indonesia and China were screened by PCR to detect infectious hypodermal and hematopoietic necrosis virus (IHHNV or Decapod penstylhamaparvovirus 1). IHHNV was detected in tissue samples pooled from nine out of ten batches of red claw crayfish imported from Indonesia. Phylogenetic analysis of PCR amplicons from representative pools clustered the IHHNV strain with infectious-type II sequences commonly detected in Southeast Asian countries rather than with type III strains detected previously in whiteleg shrimp (Penaeus vannamei) cultured in South Korea. IHHNV DNA was detected most frequently in the muscle (eight batches, 66.7% samples), followed by in the hepatopancreas (five batches, 41.7% samples) and gills tissue (three batches, 25.0% samples). These data suggest that red claw crayfish could be a potential carrier of the virus and that quarantine procedures must be strengthened in South Korea to avoid importing infectious types of IHHNV in commodity crustaceans such as red claw crayfish.
Current and Prospective Radiation Detection Systems, Screening Infrastructure and Interpretive Algorithms for the Non-Intrusive Screening of Shipping Container Cargo: A Review
Authors: Connolly Euan L. , Martin Peter G.
Published: August 2021

The non-intrusive screening of shipping containers at national borders serves as a prominent and vital component in deterring and detecting the illicit transportation of radioactive and/or nuclear materials which could be used for malicious and highly damaging purposes. Screening systems for this purpose must be designed to efficiently detect and identify material that could be used to fabricate radiological dispersal or improvised nuclear explosive devices, while having minimal impact on the flow of cargo and also being affordable for widespread implementation. As part of current screening systems, shipping containers, offloaded from increasingly large cargo ships, are driven through radiation portal monitors comprising plastic scintillators for gamma detection and separate, typically 3He-based, neutron detectors. Such polyvinyl-toluene plastic-based scintillators enable screening systems to meet detection sensitivity standards owing to their economical manufacturing in large sizes, producing high-geometric-efficiency detectors. However, their poor energy resolution fundamentally limits the screening system to making binary “source” or “no source” decisions. To surpass the current capabilities, future generations of shipping container screening systems should be capable of rapid radionuclide identification, activity estimation and source localisation, without inhibiting container transportation. This review considers the physical properties of screening systems (including detector materials, sizes and positions) as well as the data collection and processing algorithms they employ to identify illicit radioactive or nuclear materials. The future aim is to surpass the current capabilities by developing advanced screening systems capable of characterising radioactive or nuclear materials that may be concealed within shipping containers.
Essential Role of COP9 Signalosome Subunit 5 (Csn5) in Insect Pathogenicity and Asexual Development of Beauveria bassiana
Authors: Mou Ya-Ni , Ren Kang , Tong Sen-Miao , Ying Sheng-Hua , Feng Ming-Guang
Published: August 2021

Csn5 is a subunit ofthe COP9/signalosome complex in model fungi. Here, we report heavier accumulation of orthologous Csn5 in the nucleus than in the cytoplasm and its indispensability to insect pathogenicity and virulence-related cellular events of Beauveria bassiana. Deletion of csn5 led to a 68% increase in intracellular ubiquitin accumulation and the dysregulation of 18 genes encoding ubiquitin-activating (E1), -conjugating (E2), and -ligating (E3) enzymes and ubiquitin-specific proteases, suggesting the role of Csn5 in balanced ubiquitination/deubiquitination. Consequently, the deletion mutant displayed abolished insect pathogenicity, marked reductions in conidial hydrophobicity and adherence to the insect cuticle, the abolished secretion of cuticle penetration-required enzymes, blocked haemocoel colonisation, and reduced conidiation capacity despite unaffected biomass accumulation. These phenotypes correlated well with sharply repressed or abolished expressions of key hydrophobin genes required for hydrophobin biosynthesis/assembly and of developmental activator genes essential for aerial conidiation and submerged blastospore production. In the mutant, increased sensitivities to heat shock and oxidative stress also correlated with reduced expression levels of several heat-responsive genes and decreased activities of antioxidant enzymes. Altogether, Csn5-reliant ubiquitination/deubiquitination balance coordinates the expression of those crucial genes and the quality control of functionally important enzymes, which are collectively essential for fungal pathogenicity, virulence-related cellular events, and asexual development.
Bridging the Gap: How Gender Influences Spanish Politicians’ Activity on Twitter
Authors: Guerrero-Solé Frederic , Perales-García Cristina
Published: August 2021

Women have historically been underrepresented in politics. However, in the last few decades, more and more women have been elected to both upper and lower houses, particularly in Spain. Social media has become one >of the main channels for women to gain visibility, but the issue of unequal distribution of power and influence between men and women remains. This paper sheds light on gender differences among politicians on Twitter by analyzing the social media activity and influence of 277 of the 350 Members of the Spanish Congress of Deputies from March to June 2020. Our research shows there are still major gender differences regarding audience figures and amplification and that both male and female politicians still largely retweet more men than women. In addition, we found significant differences between parties and across the political spectrum, although these are less prominent (albeit not neutralized) in parties with a female leader. This is in keeping with studies that have found broad similarities between male and female politicians’ communicative practices, but a persistently large gap to be bridged in terms of their online influence. Female leaders are proposed as a means to bridge this gap.
Associations between Metabolic Syndrome and Obesity-Related Indices and Bone Mineral Density T-Score in Hemodialysis Patients
Authors: Wung Chih-Hsuan , Chung Cheng-Yin , Wu Pei-Yu , Huang Jiun-Chi , Tsai Yi-Chun , Chen Szu-Chia , Chiu Yi-Wen , Chang Jer-Ming
Published: August 2021

Previous studies have reported inconsistent results regarding the associations between metabolic syndrome (MetS) and obesity-related indices and bone mineral density (BMD). However, no previous studies have reported these associations among hemodialysis (HD) patients. The aims of this study were to investigate associations between MetS and its components and BMD T-score in HD patients and also between obesity-related indices and BMD T-score in HD patients with and without MetS. MetS was defined according to the Adult Treatment Panel III for Asians, and BMD T-score was calculated using dual-energy X-ray absorptiometry. Eight obesity-related indices were evaluated, including lipid accumulation product (LAP), visceral adiposity index (VAI), body adiposity index, conicity index (CI), body roundness index (BRI), abdominal volume index (AVI), waist-to-height ratio (WHtR), waist–hip ratio, and body mass index (BMI). One hundred and sixty-four patients undergoing HD were enrolled, and the prevalence of MetS was 61.6%. MetS was significantly associated with high lumbar spine and total hip T-scores. Regarding the MetS components, abdominal obesity and low HDL-C were significantly associated with high lumbar spine, femoral neck, and total hip T-scores; hypertriglyceridemia was significantly associated with high lumbar spine and total hip T-scores; hyperglycemia was significantly associated with a high lumbar spine T-score, whereas high blood pressure was not associated with T-score at any site. In the patients with MetS, BMI, WHtR, AVI, and BRI were significantly associated with T-score at all sites, and high CI, VAI, and LAP were also related to a high lumbar T-score. However, these indices were not associated with T-score at any site in patients without MetS. This study demonstrated positive associations between MetS and its five components and BMD T-score among HD patients. MetS, abdominal obesity, hypertriglyceridemia, and low HDL-cholesterol were associated with low risk of osteoporosis among the HD patients. Furthermore, we found that some obesity-related indices were associated with BMD T-score among HD patients with MetS but not in those without MetS. Our study highlights the importance of BMI, WHtR, AVI, and BRI in predicting the risk of osteoporosis among HD patients with MetS. In clinical practice, they can be easily calculated through simple anthropometric measurements and routine laboratory examinations and be used to quickly and conveniently assess the risk of osteoporosis among HD patients.
The Print Media Convergence: Overall Trends and the COVID-19 Pandemic Impact
Authors: Sheresheva Marina , Skakovskaya Lyudmila , Bryzgalova Elena , Antonov-Ovseenko Anton , Shitikova Helen
Published: August 2021

The study presented in the paper aims to analyze the Russian print media market before and during the COVID-19 pandemic, as well as the prospects of local media transformation in the challenging environment. In the pre-pandemic decade, there was a growing body of literature on media convergence in emerging markets confirming that this concept is growing in importance as a strategic path of conventional media transformation. Still, the research on the Russian conventional media transformation is scarce, the impact of the COVID-19 pandemic risks on Russian print media and their business models have not been investigated so far. To fill the gap, we combined desk research, processing of published industry statistics, and data obtained by means of expert interviews. The results confirm that in the first decades of the 21st century Russian print media paid less attention to the opportunities of media convergence than Western ones. At the same time, those Russian conventional media that set ambitious goals for their future considered the adoption of the media convergence approach as crucial, even before the pandemic. The findings show the lack of systemic measures to improve the overall situation on the national media market that faces difficult times, and the need to take into account pandemic risks in the print media management activities.
First Nanoparticles of a Conductor Based on the Organic Donor Molecule BETS: κ-(BETS)2FeCl4
Authors: Jacob Kane , Faulmann Christophe , de Caro Dominique , Valade Lydie
Published: August 2021

Nanoparticles of the molecular superconductor (BETS)2FeCl4 were obtained by the electrochemical oxidation of BETS in the presence of [(C2H5)4N]FeCl4 and an amphiphilic imine (OATM), acting as a growth controlling agent. When the reaction was carried out with a molar ratio OATM/BETS of 10, roughly spherical nanoparticles exhibiting sizes in the 10–40 nm range were observed. X-ray diffraction patterns evidenced the growth of (BETS)2FeCl4 nanoparticles with the κ-type structure. The current-voltage characteristic recorded on an individual nanoparticle aggregate was fitted with a Shockley diode model. A saturation current of 1216 pA and a threshold voltage of 0.62 V were extracted from this model. This latter value was consistent with roughly half of the energy gap of the semiconducting nano-crystalline aggregate.
Research on Vehicle Adaptive Cruise Control Method Based on Fuzzy Model Predictive Control
Authors: Mao Jin , Yang Lei , Hu Yuanbo , Liu Kai , Du Jinfu
Published: August 2021

Under complex working conditions, vehicle adaptive cruise control (ACC) systems with fixed weight coefficients cannot guarantee good car following performance under all conditions. In order to improve the tracking and comfort of vehicles in different modes, a fuzzy model predictive control (Fuzzy-MPC) algorithm is proposed. Based on the comprehensive consideration of safety, comfort, fuel economy and vehicle limitations, the objective function and constraints are designed. A relaxation factor vector is introduced to soften the hard constraint boundary in order to solve this problem, for which there was previously no feasible solution. In order to maintain driving stability under complex conditions, a multi-objective optimization method, which can update the weight coefficient online, is proposed. In the numerical simulation, the values of velocity, relative distance, acceleration and acceleration change rate under different conditions are compared, and the results show that the proposed algorithm has better tracking and stability than the traditional algorithm. The effectiveness and reliability of the Fuzzy-MPC algorithm are verified by co-simulation with the designed PID lower layer control algorithm with front feedforward and feedback.
Thermal Scaling of Transient Heat Transfer in a Round Cladded Rod with Modern Dimensional Analysis
Authors: Gálfi Botond-Pál , Száva Ioan , Șova Daniela , Vlase Sorin
Published: August 2021

Heat transfer analysis can be studied efficiently with the help of so-called modern dimensional analysis (MDA), which offers a uniform and easy approach, without requiring in-depth knowledge of the phenomenon by only taking into account variables that may have some influence. After a brief presentation of the advantages of this method (MDA), the authors applied it to the study of heat transfer in straight bars of solid circular section, protected but not thermally protected with layers of intumescent paints. Two cases (two sets of independent variables) were considered, which could be easily tracked by experimental measurements. The main advantages of the model law obtained are presented, being characterized by flexibility, accuracy, and simplicity. Additionally, this law and the MDA approach allow us to obtain much more advantageous models from an experimental point of view, with the geometric analogy of the model with the prototype not being a necessary condition. To the best knowledge of the present authors there are no studies reporting the application of the MDA method as it was used in this paper to heat transfer.
A Novel Approach for Group Decision Making Based on the Best–Worst Method (G-BWM): Application to Supply Chain Management
Authors: Haseli Gholamreza , Sheikh Reza , Wang Jianqiang , Tomaskova Hana , Tirkolaee Erfan Babaee
Published: August 2021

Due to the complexity of real-world multi-criteria decision-making (MCDM) issues, analyzing different opinions from a group of decision makers needs to ensure appropriate decision making. The group decision-making methods collect preferences of the decision makers and present the best preferences using mathematical equations. The best–worst method (BWM) is one of the recently introduced MCDM methods that requires fewer pairwise comparisons to obtain the criteria weights than the other MCDM methods. In this research, we develop a novel approach to group decision-making problems based on the BWM called G-BWM. This approach helps us to analyze the preferences of decision makers to carry out democratic decision making using the BWM structure. In order to assess the applicability of the proposed methodology and represent its novelty, two numerical examples from the literature with the application to supply chain management (SCM) (i.e., green supplier selection and supplier development/segmentation) are examined and discussed. The results demonstrate the performance of our proposed G-BWM for group decision making in terms of a large number of decision makers, ease of use and achieving democratic decisions in the decision-making process.
Ensemble Model of the Financial Distress Prediction in Visegrad Group Countries
Authors: Pavlicko Michal , Durica Marek , Mazanec Jaroslav
Published: August 2021

The issue of prediction of financial state, or especially the threat of the financial distress of companies, is very topical not only for the management of the companies to take the appropriate actions but also for all the stakeholders to know the financial health of the company and its possible future development. Therefore, the main aim of the paper is ensemble model creation for financial distress prediction. This model is created using the real data on more than 550,000 companies from Central Europe, which were collected from the Amadeus database. The model was trained and validated using 27 selected financial variables from 2016 to predict the financial distress statement in 2017. Five variables were selected as significant predictors in the model: current ratio, return on equity, return on assets, debt ratio, and net working capital. Then, the proposed model performance was evaluated using the values of the variables and the state of the companies in 2017 to predict financial status in 2018. The results demonstrate that the proposed hybrid model created by combining methods, namely RobustBoost, CART, and k-NN with optimised structure, achieves better prediction results than using one of the methods alone. Moreover, the ensemble model is a new technique in the Visegrad Group (V4) compared with other prediction models. The proposed model serves as a one-year-ahead prediction model and can be directly used in the practice of the companies as the universal tool for estimation of the threat of financial distress not only in Central Europe but also in other countries. The value-added of the prediction model is its interpretability and high-performance accuracy.
Study of the Boundary Value Problems for Nonlinear Wave Equations on Domains with a Complex Structure of the Boundary and Prehistory
Authors: Marynets Vasyl , Marynets Kateryna , Kohutych Oksana
Published: August 2021

We study a boundary value problem for nonlinear partial differential equations of the hyperbolic type on the plain in a domain with a complex boundary. To find the missing data for the given boundary constraints, we solve a supplementary nonlinear problem. For the approximation of solutions, one constructive method is built.
Diagnostic Accuracy and Prognostic Value of Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Septic Patients outside the Intensive Care Unit
Authors: Spoto Silvia , Lupoi Domenica Marika , Valeriani Emanuele , Fogolari Marta , Locorriere Luciana , Beretta Anguissola Giuseppina , Battifoglia Giulia , Caputo Damiano , Coppola Alessandro , Costantino Sebastiano , Ciccozzi Massimo , Angeletti Silvia
Published: August 2021

Background and Objectives: The aim of this study was to evaluate the diagnostic accuracy and prognostic value of neutrophil-to-lymphocyte (NLR) and platelet-to-lymphocyte (PLR) ratios and to compare them with other biomarkers and clinical scores of sepsis outside the intensive care unit. Materials and methods: In this retrospective study, 251 patients with sepsis and 126 patients with infection other than sepsis were enrolled. NLR and PLR were calculated as the ratio between absolute values of neutrophils, lymphocytes, and platelets by complete blood counts performed on whole blood by Sysmex XE-9000 (Dasit, Italy) following the manufacturer’s instruction. Results: The best NLR value in diagnosis of sepsis was 7.97 with sensibility, specificity, AUC, PPV, and NPV of 64.26%, 80.16%, 0.74 (p < 0.001), 86.49%, and 53.18%, respectively. The diagnostic role of NLR significantly increases when PLR, C-reactive protein (PCR), procalcitonin (PCT), and mid-regional pro-adrenomedullin (MR-proADM) values, as well as systemic inflammatory re-sponse syndrome (SIRS), sequential organ failure assessment (SOFA), and quick-sequential organ failure assessment (qSOFA) scores, were added to the model. The best value of NLR in predicting 90-day mortality was 9.05 with sensibility, specificity, AUC, PPV, and NPV of 69.57%, 61.44%, 0.66 (p < 0.0001), 28.9%, and 89.9%, respectively. Sensibility, specificity, AUC, PPV, and NPV of NLR increase if PLR, PCR, PCT, MR-proADM, SIRS, qSOFA, and SOFA scores are added to NLR. Conclusions: NLR and PLR represent a widely useful and cheap tool in diagnosis and in predict-ing 90-day mortality in patients with sepsis.
The Patient-Reported Outcome Measures Used with Low Back Pain and the Attitude of Primary Healthcare Practitioners in Saudi Arabia toward Them
Authors: Alhowimel Ahmed , Alodaibi Faris , Alotaibi Mazyad , Alamam Dalyah , Fritz Julie
Published: August 2021

Background and objectives: The use of appropriate outcome measures can help guide multidimensional low back pain (LBP) management, elucidate the efficacy/effectiveness of interventions, and inform clinicians when selected targets have been achieved and this can be used for educational or research purposes. Aim: This study aimed to explore and describe the use, attitudes, knowledge, and beliefs regarding patient-reported outcome measures used by healthcare practitioners practising in Saudi Arabia who are frequently involved in the healthcare of individuals with LBP. Materials and Methods: A cross-sectional design was undertaken using a web-based survey. An electronic invitation to participate was sent to primary care physicians and physical therapists practising in Saudi Arabia. The survey included three sections: demographic data, a list of the most commonly used patient-reported outcome measures with LBP patients, and statements regarding attitudes, knowledge, and beliefs about outcome measures. Results: A total of 156 practitioners participated: 45 primary care physicians and 111 physical therapists. The numeric pain rating and visual analogue scales were the outcome measures most frequently reported as being often used by both primary care physicians and physical therapists. The majority of participants reported often using 1–2 patient reported outcome measures (PROMs). While most participants indicated that they were confident at selecting the most appropriate PROM, fewer were familiar with the concept of the minimally important clinical difference. A lack of Arabic versions of PROMs was reported as a barrier to using them to assess pain. Conclusions: This study shows that, although primary care physicians and physical therapists in Saudi Arabia frequently use patient-reported outcome measures in their clinical management of patients with LBP, there is a noticeable gap in the knowledge and use of the multidimensional outcome measures for LBP management among the participants. This highlights a need for professional training on the use of standardised outcome measures related to LBP.
The Prognostic Role of Cytogenetics Analysis in Philadelphia Negative Myeloproliferative Neoplasms
Authors: Lanzarone Giuseppe , Olivi Matteo
Published: August 2021

Myeloproliferative neoplasms (MPNs) are clonal stem cell disorders characterized collectively by clonal proliferation of myeloid cells with variable morphologic maturity and hematopoietic efficiency. Although the natural history of these neoplasms can be measured sometimes in decades more than years, the cytogenetics analysis can offer useful information regarding the prognosis. Cytogenetics has a well-established prognostic role in acute leukemias and in myelodysplastic syndromes, where it drives the clinical decisions. NGS techniques can find adverse mutations with clear prognostic value and are currently included in the prognostic evaluation of MPNs in scores such as MIPSS, GIPSS, MIPSS-PV, and MIPSS-ET. We suggest that cytogenetics (considering its availability and relative cost) has a role regarding prognostic and therapeutic decisions.
Advances in the Synthesis and Application of Anti-Fouling Membranes Using Two-Dimensional Nanomaterials
Authors: Shahzad Asif , Oh Jae-Min , Azam Mudassar , Iqbal Jibran , Hussain Sabir , Miran Waheed , Rasool Kashif
Published: August 2021

This article provides a comprehensive review of the recent progress in the application of advanced two-dimensional nanomaterials (2DNMs) in membranes fabrication and application for water purification. The membranes fouling, its types, and anti-fouling mechanisms of different 2DNMs containing membrane systems are also discussed. The developments in membrane synthesis and modification using 2DNMs, especially graphene and graphene family materials, carbon nanotubes (CNTs), MXenes, and others are critically reviewed. Further, the application potential of next-generation 2DNMs-based membranes in water/wastewater treatment systems is surveyed. Finally, the current problems and future opportunities of applying 2DNMs for anti-fouling membranes are also debated.
Association between Gut Microbiota and Development of Gestational Diabetes Mellitus
Authors: Sililas Palin , Huang Lingling , Thonusin Chanisa , Luewan Suchaya , Chattipakorn Nipon , Chattipakorn Siriporn , Tongsong Theera
Published: August 2021

Background: It is well known that women with gestational diabetes mellitus (GDM) have gut dysbiosis. However, the dynamic alterations of gut microbiota in GDM are unclear. Additionally, the effects of maternal gut microbiota on the gut microbiota of their newborns remains controversial. The primary objective of this study is to determine the association between types and amounts of gut microbiota and development of gestational diabetes mellitus (GDM). Methods: Eighty-eight pregnant women, including 39 non-GDM and 49 GDM, and their 88 offspring were enrolled. Maternal feces were collected at the time of GDM diagnosis (24–28 weeks of gestation) and at before delivery (≥37 weeks of gestation). Meconium and the first feces of their newborns were also obtained. Results: from quantitative polymerase chain reaction (qPCR) showed that maternal Lactobacillales was decreased from baseline to the time before delivery in both non-GDM and GDM. Firmicutes/Bacteroidetes (F/B) ratio at before delivery was higher in the GDM group. However, there was no difference of neonatal gut microbiota between groups. Conclusions: Although we found only few gut microbiota that demonstrated the difference between GDM and non-GDM, gut microbiota may play a more important role in the development of severer GDM. Therefore, a further study comparing the gut microbiota composition among non-GDM, GDM with diet modification only, GDM with insulin therapy, GDM with successful treatment, and GDM with failure of treatment is needed.
In Silico Identification of Tripeptides as Lead Compounds for the Design of KOR Ligands
Authors: Stefanucci Azzurra , Iobbi Valeria , Della Valle Alice , Scioli Giuseppe , Pieretti Stefano , Minosi Paola , Mirzaie Sako , Novellino Ettore , Mollica Adriano
Published: August 2021

The kappa opioid receptor (KOR) represents an attractive target for the development of drugs as potential antidepressants, anxiolytics and analgesics. A robust computational approach may guarantee a reduction in costs in the initial stages of drug discovery, novelty and accurate results. In this work, a virtual screening workflow of a library consisting of ~6 million molecules was set up, with the aim to find potential lead compounds that could manifest activity on the KOR. This in silico study provides a significant contribution in the identification of compounds capable of interacting with a specific molecular target. The main computational techniques adopted in this experimental work include: (i) virtual screening; (ii) drug design and leads optimization; (iii) molecular dynamics. The best hits are tripeptides prepared via solution phase peptide synthesis. These were tested in vivo, revealing a good antinociceptive effect after subcutaneous administration. However, further work is due to delineate their full pharmacological profile, in order to verify the features predicted by the in silico outcomes.