bluuebunny/crossref_metadata_2025 huggingface dataset:
Confronting School Violence
Authors: Turanovic Jillian J. , Pratt Travis C. , Kulig Teresa C. , Cullen Francis T.
Published: March 2022

School violence is a significant social concern. To better understand its sources, a comprehensive meta-analysis of the school violence and victimization literature was undertaken. Across 761 studies, the relative effects of 30 different individual, school, and community level correlates were assessed (8,790 effect size estimates). Violence and victimization were conceptualized broadly to include various forms of aggression and crime at school. The results revealed that the strongest correlates of school violence perpetration were antisocial behavior, deviant peers, antisocial attitudes, victimization, and peer rejection; and that the strongest correlates of school victimization were prior/other victimization, social competence, risk avoidance, antisocial behavior, and peer rejection. Extracurricular activities and school security devices had among the weakest associations in the meta-analysis, and several traditional criminological predictors did not perform well in the school context. We conclude with recommendations for theory, future research, and policy.
A prospective, multicenter, clinical study of duodenoscope contamination after reprocessing
Authors: Okamoto Naoaki , Sczaniecka Anna , Hirano Misa , Benedict Melinda , Baba Shigeyoshi , Horino Yoko , Takenouchi Masato , Morizane Yuichi , Yana Ikuo , Segan Ross , Pineau Lionel , Alfa Michelle J.
Published: March 2022

Objective:

Several clinical procedures utilize duodenoscopes, which are processed for reuse after the procedures are completed. However, infection outbreaks due to improper duodenoscope processing occur frequently. To address this, we aimed to assess the contamination rates of duodenoscopes after reprocessing in nonoutbreak settings.

Design and setting:

Prospective study in 16 clinical sites in the United States.

Methods:

We sampled and cultured reprocessed duodenoscopes following the FDA/CDC/ASM guideline; “Duodenoscope Surveillance Sampling and Culturing – Reducing the Risks of Infection.” High-concern (HC) organisms were those highly associated with disease, including gram-negative rods, Staphylococcus aureus, Staphylococcus lugdunensis, β-hemolytic Streptococcus, Enterococcus spp, and yeasts. We evaluated duodenoscopes with ≥1 CFU of organisms after reprocessing. The reprocessing environments were also sampled and cultured.

Results:

We assessed 859 newer-model (NM) duodenoscopes (TJF-Q180V) and 850 older-model (OM) duodenoscopes (TJF-160F/VF); of these, 35 NM samples (4.1%) and 56 OM samples (6.6%) were contaminated with HC organisms. We detected and classified the HC organisms as gastrointestinal (45.4%), human origin (16.7%), environmental (24.1%), waterborne (13.0%), and unidentified (0.9%).

Conclusions:

We detected an overall HC contamination rate of 5.3% in nonoutbreak settings. Although the relationship between endoscopic contamination and the occurrence of infections remains unclear, attempts should continue to be made to further reduce contamination rates. Additional improvements to the manufacturer’s instructions for use, human factors during the reprocessing procedure, ongoing training programs, cleanliness of reprocessing environments, and the design of the distal end of the duodenoscope should be considered.
Transient wave-induced pore-water-pressure and soil responses in a shallow unsaturated poroelastic seabed
Authors: Tong Linlong , Liu Philip L.-F.
Published: March 2022

An analytical solution is developed for studying transient water wave-induced responses inside an unsaturated poroelastic seabed of finite thickness. The soil skeleton and the pore fluid are compressible and the constitutive relationship of the soil skeleton is described by Hooke's law. Assuming that the horizontal length scale of wave motion is much larger than the seabed thickness, the leading-order analytical solutions for the seabed responses, including pore fluid pressure and soil skeleton motion, are obtained. The present solutions are suitable for general transient wave loading and for the shear modulus of the soil skeleton being of the same order of magnitude as the effective bulk modulus of elasticity of the pore fluid. The present theory is first validated by checking the solutions with the experimental data for the pore pressure induced by periodic-wave loading. The present analytical solutions are then used to investigate the seabed responses under transient waves, including linear periodic wave, a solitary wave and a bore. The effects of the wave-induced effective stresses on the bed failure potential are further analysed. The results show that the shear failure potential and its duration are highly dependent on the soil properties, such as saturation degree, shear modulus and permeability. Sensitivity analyses are presented.
Taking Distributions Seriously: On the Interpretation of the Estimates of Interactive Nonlinear Models
Authors: Zhirnov Andrei , Moral Mert , Sedashov Evgeny
Published: March 2022

In recent decades, political science literature has experienced significant growth in the popularity of nonlinear models with multiplicative interaction terms. When one or more constitutive variables are not binary, most studies report the marginal effect of the variable of interest at its sample mean while allowing the other constitutive variable/s to vary along its range and holding all other covariates constant at their means, modes, or medians. In this article, we argue that this conventional approach is not always the most suitable since the marginal effect of a variable at its sample mean might not be sufficiently representative of its prevalent effect at a specific value of the conditioning variable and might produce excessively model-dependent predictions. We propose two procedures to help researchers gain a better understanding of how the typical effect of the variable of interest varies as a function of the conditioning variable: (1) computing and plotting the marginal effects at all in-sample combinations of the values of the constitutive variables and (2) computing and plotting what we call the “Distribution-Weighted Average Marginal Effect” over the values of the conditioning variable.
STALLWORK IN CHRISTCHURCH PRIORY, DORSET: A FRANCO-FLEMISH ALL’ANTICA WORK OF THE EARLY 1520s
Authors: Riall Nicholas
Published: March 2022

Critical analysis of the quire stalls in the Augustinian priory in Christchurch has revealed that they are an important set of early all’antica styled stalls that were created by ‘alien’ craftsmen, no earlier than c 1520. Many traces of Continental joinery techniques, not then used in England, particularly the use of lamination, support this view. It has long been thought that they were cobbled together from sets of stalls of various dates, but they are all of one period. Much has been lost and many of the parts have been replaced, especially so among the dossiers. The idea that many of the misericords are missing can be discounted because the design of the stalls disproves this. This important set of quire stalls represents one of the last made prior to the Reformation – but they are much misunderstood.
Alterations in the inferior fronto-occipital fasciculus – a specific neural correlate of gender incongruence?
Authors: van Heesewijk Jason , Steenwijk Martijn D. , Kreukels Baudewijntje P. C. , Veltman Dick J. , Bakker Julie , Burke Sarah M.
Published: March 2022

Background

Increasing numbers of adolescents seek help for gender-identity questions. Consequently, requests for medical treatments, such as puberty suppression, are growing. However, studies investigating the neurobiological substrate of gender incongruence (when birth-assigned sex and gender identity do not align) are scarce, and knowledge about the effects of puberty suppression on the developing brain of transgender youth is limited.

Methods

Here we cross-sectionally investigated sex and gender differences in regional fractional anisotropy (FA) as measured by diffusion MR imaging, and the impact of puberty on alterations in the white-matter organization of 35 treatment-naive prepubertal children and 41 adolescents with gender incongruence, receiving puberty suppression. The transgender groups were compared with 79 age-matched, treatment-naive cisgender (when sex and gender align) peers.

Results

We found that transgender adolescents had lower FA in the bilateral inferior fronto-occipital fasciculus (IFOF), forceps major and corpus callosum than cisgender peers. In addition, average FA values of the right IFOF correlated negatively with adolescents' cumulative dosage of puberty suppressants received. Of note, prepubertal children also showed significant FA group differences in, again, the right IFOF and left cortico-spinal tract, but with the reverse pattern (transgender > cisgender) than was seen in adolescents.

Conclusions

Importantly, our results of lower FA (indexing less longitudinal organization, fiber coherence, and myelination) in the IFOF of gender-incongruent adolescents replicate prior findings in transgender adults, suggesting a salient neural correlate of gender incongruence. Findings highlight the complexity with which (pubertal) sex hormones impact white-matter development and add important insight into the neurobiological substrate associated with gender incongruence.
Prevalence, correlates, and mental health burden associated with homelessness in U.S. military veterans
Authors: Nichter Brandon , Tsai Jack , Pietrzak Robert H.
Published: March 2022

Background

Homelessness is a major public health problem among U.S. military veterans. However, contemporary, population-based data on the prevalence, correlates, and mental health burden of homelessness among veterans are lacking.

Methods

Data were analyzed from the 2019–2020 National Health and Resilience in Veterans Study, a nationally representative survey of veterans (n = 4069). Analyses examined the prevalence and correlates of homelessness, as well as the independent associations between homelessness and current probable psychiatric conditions, suicidality, and functioning.

Results

The lifetime prevalence of homelessness was 10.2% (95% confidence interval 9.3–11.2). More than 8-of-10 veterans reported experiencing their first episode of homelessness following military service, with a mean of 10.6 years post-discharge until onset (s.d. = 12.6). Adverse childhood experiences (ACEs), cumulative trauma burden, current household income, younger age, and drug use disorder emerged as the strongest correlates of homelessness (49% of total explained variance). Veterans with a history of homelessness had elevated odds of lifetime suicide attempt, attempting suicide two or more times, and past-year suicide ideation [odd ratios (ORs) 1.3–3.1]. They also had higher rates of current probable posttraumatic stress disorder, major depressive, generalized anxiety, and drug use disorders (ORs 1.7–2.4); and scored lower on measures of mental, physical, cognitive, psychosocial functioning (d = 0.11–0.15).

Conclusions

One in ten U.S. veterans has experienced homelessness, and these veterans represent a subpopulation at substantially heightened risk for poor mental health and suicide. ACEs were the strongest factor associated with homelessness, thus underscoring the importance of targeting early childhood adversities and their mental health consequences in prevention efforts for homelessness in this population.
The (white) ears of Ofsted: A raciolinguistic perspective on the listening practices of the schools inspectorate
Authors: Cushing Ian , Snell Julia
Published: March 2022

England has had a schools inspectorate since 1839, first in the form of Her Majesty's Inspectorate (HMI), and since 1992, in the form of the Office for Standards in Education, Children's Services and Skills (Ofsted). The inspectorate, a workforce made up of a majority of white inspectors, conduct regular inspections of all state schools in England, producing reports which comment on various aspects of educational provision, including teachers’ and students’ spoken language. In this article we deploy a raciolinguistic genealogy to examine the listening practices of the inspectorate, drawing on historical inspection reports generated from archival work, inspectorate language policy, and a large corpus of contemporary reports. We show how raciolinguistic ideologies are deeply embedded into the sociopolitical culture of the inspectorate, and how these ideologies translate into systems of sonic surveillance in which the nonstandardised language practices of students and teachers are heard as impoverished, deficient, and unsuitable for school. (Raciolinguistics, schools, language policing, standardised English, Ofsted, England, social class, ideology)
A fish tale about “fieldwork,” or toward multilingual interviewing in applied linguistics
Authors: Thomas Jamie A.
Published: March 2022

Focused as we are on uncovering how language works, many linguists are less cognizant of how the communicative strategies we employ in our knowledge-gathering activities impact the language users, identities, and communities we connect with and learn from. This autoethnographic essay, offered as a critical, introspective and analytical account by a U.S.-based, African American woman researcher, unfolds across three scenes of embedded ethnographic research in Micronesia and Tanzania—ocean-facing nations separated by a distance of more than 12,000 kilometers. Each scene's storytelling and dialogue—among users of Pohnpeian and Nukuoro in Micronesia, and users of Korean and Swahili in Tanzania—depicts how competing ideas about the value of marginalized languages surface within the talk of the research interview through allusions to socioracial power and linguistic capital. The essay concludes with a discussion of how a shift toward multilingual, multi-person interviewing can expand and deepen the insights of language-focused research.
The role of perceived threats on mental health, social, and neurocognitive youth outcomes: A multicontextual, person-centered approach
Authors: Conley May I. , Hernandez Jasmine , Salvati Joeann M. , Gee Dylan G. , Baskin-Sommers Arielle
Published: March 2022

Perceived threat in youth’s environments can elevate risk for mental health, social, and neurocognitive difficulties throughout the lifespan. However, few studies examine variability in youth’s perceptions of threat across multiple contexts or evaluate outcomes across multiple domains, ultimately limiting our understanding of specific risks associated with perceived threats in different contexts. This study examined associations between perceived threat in youth’s neighborhood, school, and family contexts at ages 9–10 and mental health, social, and neurocognitive outcomes at ages 11–12 within a large US cohort (N = 5525) enrolled in the Adolescent Brain Cognitive DevelopmentSM Study (ABCD Study®). Latent profile analysis revealed four distinct profiles: Low Threat in all contexts, Elevated Family Threat, Elevated Neighborhood Threat, and Elevated Threat in all contexts. Mixed-effect models and post hoc pairwise comparisons showed that youth in Elevated Threat profile had poorer mental health and social outcomes 2 years later. Youth in the Elevated Family Threat profile uniquely showed increased disruptive behavior symptoms, whereas youth in the Elevated Neighborhood Threat profile predominantly displayed increased sleep problems and worse neurocognitive outcomes 2 years later. Together, findings highlight the importance of considering perceptions of threat across multiple contexts to achieve a more nuanced developmental picture.
Effect of treadmill exercise stress testing on troponin levels in children and adolescents
Authors: Pompa Anthony G. , Arora Gaurav , Harris Tyler H.
Published: March 2022

Background:

Chest pain is a common complaint among paediatric patients and cardiac troponin (cTn) level is often part of the initial emergency department evaluation. It is well known that after intense endurance exercise cTn levels can be elevated in patients with otherwise healthy hearts, however the effect shorter duration exercise has on cTn levels in this population is not known.

Objective:

Determine the behaviour of cTn levels in healthy children and adolescent patients after short burst, high-intensity aerobic exercise.

Methods:

Patients without haemodynamically significant heart disease referred for a treadmill exercise stress test (EST) were recruited over a 6-month period. cTn levels were measured prior to exercise and 4 hours after exercise.

Results:

Thirteen patients enrolled. Indications for EST were exertional syncope (six), chest pain (four), and long QT syndrome (three). The median exercise time was 12.9 (9.9–13.7) minutes with an average endurance at the fiftieth percentile for age and maximum heart rate rose to an average of 92 (74–98)% of the predicted peak for age. cTn levels prior to exercise were undetectable in all patients. There was no cTn rise in any patient after exercise. There were no ischaemic changes or arrhythmias on exercise electrocardiograms.

Conclusion:

Serum cTn levels do not rise significantly in healthy children after short duration, high-intensity aerobic exercise. Physicians evaluating paediatric patients with an elevated cTn level after less than prolonged strenuous activity likely cannot attribute this lab value solely to exercise and may need to undertake further cardiac investigation.
Between Demographic Optimism and Pessimism?
Authors: McConnell Eileen Díaz , Rodríguez-Muñiz Michael
Published: March 2022

The U.S. Census Bureau projects that by 2060, Latinx, African Americans, Asians, and other “minority” groups will together comprise the majority of the country’s population. Past research has found that non-Hispanic Whites, hereafter Whites, find such projections disquieting or threatening. Yet, recent surveys reveal that when given more than binary good/bad choices, most Whites opt for the middle-point response that this development will be “neither good nor bad for the country.” How can we account for this seemingly ambiguous evaluation of projected ethnoracial demographic futures? Using eight waves of nationally representative U.S. survey data collected between 2015 and 2018, this article begins to unpack the “neither” response among Whites, exploring what it might mean and what factors are associated with it, relative to seemingly optimistic and pessimistic stances. Multinomial Logistic Regression analyses and additional descriptive analyses indicate that “neither good nor bad” in this context is a substantive response: White “Neithers” are socio-demographically and attitudinally distinct from their counterparts. Our study demonstrates the value of moving beyond an exclusive focus on expressions of demographic threat and pessimism. Moreover, it invites further investigation into factors that inform and shape how Whites and other ethnoracial populations in the U.S. understand and assess projected population shifts.
Characteristics of Tropical‐Cyclone Turbulence and Intensity Predictability
Authors: Kieu Chanh , Rotunno Richard
Published: March 2022

This study examines the characteristics of tropical‐cyclone (T‐C) turbulence and its related predictability implications. Using the Fourier‐Bessel spectral decomposition for convection‐permitting simulations, it is shown that T‐C turbulence possesses different spectral properties in the azimuthal and radial directions, with a steeper power law in the radial‐wavenumber than that in the azimuthal‐wavenumber direction. This spectral difference between the azimuthal and radial directions prevents one from using a single wavenumber to interpret T‐C intensity predictability as for classical homogeneous isotropic turbulence. Analyses of spectral error growth for a high‐wavenumber perturbation further confirm that the spectral growth is more rapid for high azimuthal wavenumbers than for the radial wavenumbers, reaching saturation after ∼9 hr and ∼18 hr for the azimuthal and radial directions, respectively. This result highlights the key difficulty in quantifying T‐C intensity predictability based on spectral upscale error growth for future applications.
Panoptic View of Mantle Flow Beneath Trans‐Continental Northeast Asia: Distinct Variation Detected From ∼2,000 km Shear Wave Splitting Profile
Authors: Yang Fan , Guo Guangrui , Li Juan , Chen Qi‐Fu , Chen Yun , Chen Sidan
Published: March 2022

We obtained a panoptic view of the pattern of mantle flow in the “Big Mantle Wedge” associated with the stagnation of the subducting Pacific slab. We applied a simultaneous inversion of multiple waveforms method to measure SKS‐wave splitting parameters for a dense seismic array in trans‐continental Northeast Asia. We identify distinct patterns separated by the North‐South Gravity Lineament (NSGL): to the west, the ENE fast axis orientation with small δt reflects limited frozen anisotropy in the stable lithosphere; while to the east, local variation of anisotropy is superimposed on the NNW‐dominated fast direction, suggesting contribution of other mechanisms rather than the only asthenospheric flow. Within a distance of 200 km crossing the NSGL, we reveal a gradual clockwise rotation in the fast direction, and the keel‐deflected flow caused by the 60–80 km reduction in the lithosphere thickness across the NSGL might contribute to the variation of anisotropy.
A Two‐Spacecraft Study of Mars' Induced Magnetosphere's Response to Upstream Conditions
Authors: Stergiopoulou Katerina , Andrews David J. , Edberg Niklas J. T. , Halekas Jasper , Lester Mark , Sánchez‐Cano Beatriz , Dimmock Andrew P. , Gruesbeck Jacob R.
Published: March 2022

This is a two‐spacecraft study, in which we investigate the effects of the upstream solar wind conditions on the Martian induced magnetosphere and upper ionosphere. We use Mars Express (MEX) magnetic field magnitude data together with interplanetary magnetic field (IMF), solar wind density, and velocity measurements from the Mars Atmosphere and Volatile EvolutioN (MAVEN) mission, from November 2014 to November 2018. We compare simultaneous observations of the magnetic field magnitude in the induced magnetosphere of Mars (|B|IM) with the IMF magnitude (|B|IMF), and we examine variations in the ratio |B|IM/|B|IMF with solar wind dynamic pressure, speed and density. We find that the |B|IM/|B|IMF ratio in the induced magnetosphere generally decreases with increased dynamic pressure and that a more structured interaction is seen when comparing induced fields to the instantaneous IMF, where reductions in the relative fields at the magnetic pile up boundary (MPB) are more evident than in the field strength itself, along with enhancements in the immediate vicinity of the optical shadow of Mars. We interpret these results as evidence that while the induced magnetosphere is indeed compressed and induced field strengths are higher during periods of high dynamic pressure, a relatively larger amount of magnetic flux threads the region compared to that available from the unperturbed IMF during low dynamic pressure intervals.
A New Probe Into the Innermost Inner Core Anisotropy via the Global Coda‐Correlation Wavefield
Authors: Costa de Lima Thuany , Tkalčić Hrvoje , Waszek Lauren
Published: March 2022

Investigations of the Earth's inner core (IC) using seismic body waves are limited by their volumetric sampling due to uneven global distribution of large earthquakes and receivers. The sparse coverage of the IC leads to uncertainties in its anisotropy, the directional dependence of seismic velocity. Yet, detailed constraints on anisotropy, such as its magnitude, and spatial distribution, are required to understand the crystallographic structure of IC's iron and its solidification and deformation processes. Here, we present a new method to investigate the IC's anisotropic properties based on Earth's coda‐correlation wavefield constructed from the late coda of large earthquakes. We perform a comprehensive travel time analysis of I2*, an IC‐sensitive correlation feature identified as a counterpart of the direct seismic wavefield's PKIKPPKIKP waves, yet fundamentally different. Namely, I2* is a mathematical manifestation of similarity among specific seismic phases with the same slowness detected in global correlograms in the short inter‐receiver distance range. Our new spatial sampling of the IC overcomes the shortage of direct seismic wavefield paths sensitive to the IC's central volume, also known as the innermost IC (IMIC). The observed I2*’s travel time variations relative to Earth's rotation axis (ERA) support a model of cylindrical anisotropy with 3.3% strength and a zonal pattern of slow axis oriented 55° from ERA. We thus find compelling evidence for a deep IC structure with distinct anisotropy, although we cannot resolve the depth at which the change occurs. This finding reinforces previous inference on the IMIC, with implications for Earth's evolution.
Systematic Integration of Applications into the Surface Biology and Geology (SBG) Earth Mission Architecture Study
Authors: Lee Christine M. , Glenn Nancy F. , Stavros E. Natasha , Luvall Jeff , Yuen Karen , Hain Chris , Schollaert Uz Stephanie
Published: March 2022

The Surface Biology and Geology (SBG) concept is the first National Aeronautics and Space Administration (NASA) Earth mission to develop and implement systematic integration of science application needs at the architecture study stage. Prior NASA mission concept and planning activities presumed that science measurement needs would encompasss application measurement needs and so did not explicitly evaluate and include applications at this stage. However, the effort presented here identified, documented and integrated application needs that would not have been included by considering research science needs only. First, a low latency of no greater than 24 hr was identified as the optimal target to enable the maximum number of applications and was then carried through into all SBG candidate architectures. Second, many applications expressed needs around improved spatial and temporal resolution. While increased spatial resolution would not be possible under current cost and technology considerations, the need for improved resolution for temporal sampling helped drive and bolster discussions with international partners such as the European Space Agency, Italian Space Agency, and Centre National D’Etudes Spatiales. Lastly, we found that the applications and science were synergistic with one another; for example, mission concept decisions to consider additional measurement features were driven by both high relevance application and science priorities, and in particular, evapotranspiration for agriculture and high temperature features for fires and geologic hazards. This paper discusses the process and key contributions originating from the SBG Applications Working Group and how they shaped SBG at the architecture study stage. This stage in the mission planning considers the trade space of spacecraft instruments and architectures, and evaluates which formulations are suitable candidates for SBG. The approach described here may be utilized as a framework for applications and science to inform future NASA satellite mission studies.
A Global Ocean Biogeochemical Observatory Becomes a Reality
Authors: Schofield Oscar , Fassbender Andrea , Hood Maria , Hill Katherine , Johnson Ken
Published: March 2022

Building on the successful Argo network of seafaring temperature and salinity sensors, work is underway to deploy 1,000 floats equipped to study ocean biogeochemistry in greater detail than ever.
Ultracompact meta-imagers for arbitrary all-optical convolution
Authors: Fu Weiwei , Zhao Dong , Li Ziqin , Liu Songde , Tian Chao , Huang Kun
Published: March 2022

Electronic digital convolutions could extract key features of objects for data processing and information identification in artificial intelligence, but they are time-cost and energy consumption due to the low response of electrons. Although massless photons enable high-speed and low-loss analog convolutions, two existing all-optical approaches including Fourier filtering and Green’s function have either limited functionality or bulky volume, thus restricting their applications in smart systems. Here, we report all-optical convolutional computing with a metasurface-singlet or -doublet imager, considered as the third approach, where its point spread function is modified arbitrarily via a complex-amplitude meta-modulator that enables functionality-unlimited kernels. Beyond one- and two-dimensional spatial differentiation, we demonstrate real-time, parallel, and analog convolutional processing of optical and biological specimens with challenging pepper-salt denoising and edge enhancement, which significantly enrich the toolkit of all-optical computing. Such meta-imager approach bridges multi-functionality and high-integration in all-optical convolutions, meanwhile possessing good architecture compatibility with digital convolutional neural networks.
Very-high-frequency probes for atomic force microscopy with silicon optomechanics
Authors: Schwab L. , Allain P. E. , Mauran N. , Dollat X. , Mazenq L. , Lagrange D. , Gély M. , Hentz S. , Jourdan G. , Favero I. , Legrand B.
Published: March 2022

Atomic force microscopy (AFM) has been consistently supporting nanosciences and nanotechnologies for over 30 years and is used in many fields from condensed matter physics to biology. It enables the measurement of very weak forces at the nanoscale, thus elucidating the interactions at play in fundamental processes. Here, we leverage the combined benefits of micro/nanoelectromechanical systems and cavity optomechanics to fabricate a sensor for dynamic mode AFM at a frequency above 100 MHz. This frequency is two decades above the fastest commercial AFM probes, suggesting an opportunity for measuring forces at timescales unexplored thus far. The fabrication is achieved using very-large-scale integration technologies derived from photonic silicon circuits. The probe’s optomechanical ring cavity is coupled to a 1.55 μm laser light and features a 130 MHz mechanical resonance mode with a quality factor of 900 in air. A limit of detection in the displacement of 3 × 10−16 m/√Hz is obtained, enabling the detection of the Brownian motion of the probe and paving the way for force sensing experiments in the dynamic mode with a working vibration amplitude in the picometer range. When inserted in a custom AFM instrument embodiment, this optomechanical sensor demonstrates the capacity to perform force-distance measurements and to maintain a constant interaction strength between the tip and sample, an essential requirement for AFM applications. Experiments indeed show a stable closed-loop operation with a setpoint of 4 nN/nm for an unprecedented subpicometer vibration amplitude, where the tip–sample interaction is mediated by a stretched water meniscus.
Borderline personality disorder: associations with psychiatric disorders, somatic illnesses, trauma, and adverse behaviors
Authors: Tate Ashley E. , Sahlin Hanna , Liu Shengxin , Lu Yi , Lundström Sebastian , Larsson Henrik , Lichtenstein Paul , Kuja-Halkola Ralf
Published: March 2022

In one of the largest, most comprehensive studies on borderline personality disorder (BPD) to date, this article places into context associations between this diagnosis and (1) 16 different psychiatric disorders, (2) eight somatic illnesses, and (3) six trauma and adverse behaviors, e.g., violent crime victimization and self-harm. Second, it examines the sex differences in individuals with BPD and their siblings. A total of 1,969,839 Swedish individuals were identified from national registers. Cumulative incidence with 95% confidence intervals (CI) was evaluated after 5 years of follow-up from BPD diagnosis and compared with a matched cohort. Associations were estimated as hazard ratios (HR) with 95% CIs from Cox regression. 12,175 individuals were diagnosed with BPD (85.3% female). Individuals diagnosed with BPD had higher cumulative incidences and HRs for nearly all analyzed indicators, especially psychiatric disorders. Anxiety disorders were most common (cumulative incidence 95% CI 33.13% [31.48–34.73]). Other notable findings from Cox regressions include psychotic disorders (HR 95% CI 24.48 [23.14–25.90]), epilepsy (3.38 [3.08–3.70]), violent crime victimization (7.65 [7.25–8.06]), and self-harm (17.72 [17.27–18.19]). HRs in males and females with BPD had overlapping CIs for nearly all indicators. This indicates that a BPD diagnosis is a marker of vulnerability for negative events and poor physical and mental health similarly for both males and females. Having a sibling with BPD was associated with an increased risk for psychiatric disorders, trauma, and adverse behaviors but not somatic disorders. Clinical implications include the need for increased support for patients with BPD navigating the health care system.
CircTMTC1 contributes to nasopharyngeal carcinoma progression through targeting miR-495-MET-eIF4G1 translational regulation axis
Authors: Zhao Yajie , Li Chao , Zhang Yan , Li Zhanzhan
Published: March 2022

Nasopharyngeal carcinoma (NPC) is the most common primary malignancy arising from the epithelial cells of nasopharynx. CircTMTC1 is upregulated in NPC patients, but its role and molecular mechanism in NPC are unknown. Normal nasopharyngeal epithelium and tumor tissues were collected. The expression of circTMTC1, miR-495, MET/eIF4G1 pathway-related molecules were examined. Colony formation and transwell assays were used to assess cell proliferation, migration, and invasion. Cell apoptosis was analyzed by annexin V and propidium iodide (PI) staining. Gene interaction was examined by RNA immunoprecipitation (RIP) and luciferase activity assays. Subcutaneous and intravenous xenograft mouse models were established to analyze NPC growth and metastasis in vivo. CircTMTC1 was highly expressed and miR-495 was downregulated in NPC, which were associated with poor prognosis of NPC. Both circTMTC1 knockdown and miR-495 overexpression inhibited NPC cell proliferation, migration, invasion, and epithelial–mesenchymal transition (EMT) and promoted cell apoptosis. CircTMTC1 directly targeted miR-495 to promote the expression of its downstream target gene MET. miR-495 knockdown enhanced the expression of c-Myc, Cyclin D1, and survivin and accelerated NPC cell proliferation, migration, invasion, and EMT through targeting MET and activating the MET-eIF4G1 axis. CircTMTC1 silence inhibited NPC growth and lung metastasis by targeting the miR-495-MET-eIF4G1 translational regulation axis in vivo. CircTMTC1 accelerates NPC progression through targeting miR-495 and consequently activating the MET-eIF4G1 translational regulation axis, suggesting potential therapeutic targets for NPC treatment.
Cryo-EM structure of the inner ring from the Xenopus laevis nuclear pore complex
Authors: Huang Gaoxingyu , Zhan Xiechao , Zeng Chao , Liang Ke , Zhu Xuechen , Zhao Yanyu , Wang Pan , Wang Qifan , Zhou Qiang , Tao Qinghua , Liu Minhao , Lei Jianlin , Yan Chuangye , Shi Yigong
Published: March 2022

Nuclear pore complex (NPC) mediates nucleocytoplasmic shuttling. Here we present single-particle cryo-electron microscopy structure of the inner ring (IR) subunit from the Xenopus laevis NPC at an average resolution of 4.2 Å. A homo-dimer of Nup205 resides at the center of the IR subunit, flanked by two molecules of Nup188. Four molecules of Nup93 each places an extended helix into the axial groove of Nup205 or Nup188, together constituting the central scaffold. The channel nucleoporin hetero-trimer of Nup62/58/54 is anchored on the central scaffold. Six Nup155 molecules interact with the central scaffold and together with the NDC1–ALADIN hetero-dimers anchor the IR subunit to the nuclear envelope and to outer rings. The scarce inter-subunit contacts may allow sufficient latitude in conformation and diameter of the IR. Our structure reveals the molecular basis for the IR subunit assembly of a vertebrate NPC.
Assessing the climate change exposure of foreign direct investment
Authors: Li Xia , Gallagher Kevin P.
Published: March 2022

This study deploys newly available data to examine the exposure of multinational companies’ overseas investments to physical climate risks. Globally, foreign investments are significantly exposed to lower physical climate risks, compared with local firms across countries. Within countries however, the differences of physical climate risks between foreign and local facilities are small. We also examine China, as it is fast becoming one of the largest sources of outward foreign investment across the globe. We find that foreign direct investment from China is significantly more exposed to water stress, floods, hurricanes and typhoon risks across countries, compared with other foreign facilities. Within host countries however, once again the physical climate risks of Chinese overseas facilities are comparable to those of non-Chinese foreign investments.
WTAP-mediated m6A modification of lncRNA NORAD promotes intervertebral disc degeneration
Authors: Li Gaocai , Ma Liang , He Shujie , Luo Rongjin , Wang Bingjin , Zhang Weifeng , Song Yu , Liao Zhiwei , Ke Wencan , Xiang Qian , Feng Xiaobo , Wu Xinghuo , Zhang Yukun , Wang Kun , Yang Cao
Published: March 2022

N6-methyladenosine (m6A) is the most prevalent RNA modification at the posttranscriptional level and involved in various diseases and cellular processes. However, the underlying mechanism of m6A regulation in intervertebral disc degeneration (IVDD) remains elusive. Here, we show that methylation of the lncRNA NORAD significantly increases in senescent nucleus pulposus cells (NPCs) by m6A sequencing. Subsequent loss- and gain-of-function experiments reveal WTAP is increased in senescent NPCs due to an epigenetic increase in H3K4me3 of the promoter mediated by KDM5a, and significantly promotes NORAD m6A modification. Furthermore, YTHDF2-mediated decay of NORAD is enhanced in senescent NPCs, and then deficiency of NORAD results in less sequestraion of PUMILIO proteins, contributing to the augmented activity of PUM1/2, thus repressing the expression of target E2F3 mRNAs and promoting the cellular senescence. Here, we show interruption of NORAD m6A modification or the NORAD/PUMILIO/E2F3 axis could serve as a potential therapeutic target to inhibit the senescence of NPCs and development of IVDD.
Development of primary care quality indicators for chronic obstructive pulmonary disease using a Delphi-derived method
Authors: Dewaele Sigrid , Van den Bulck Steve , Gerne Lien , Vaes Bert
Published: March 2022

High-quality care for patients with COPD is necessary. To achieve quality improvement in primary care, the general practitioner and the electronic health record (EHR) play an important role. The aim of this study was to develop a set of evidence-based and EHR extractable quality indicators (QIs) to measure and improve the quality of COPD primary care. We composed a multidisciplinary expert panel of 12 members, including patients, and used a RAND-modified Delphi method. The SMART principle was applied to select recommendations and QIs from international guidelines as well as existing sets of QIs, and these recommendations and QIs were added to an individual written questionnaire. Based on the median score, prioritization and degree of agreement, the recommendations and QIs were rated as having a high, uncertain or low potential to measure the quality of COPD primary care and were then discussed in an online consensus meeting for inclusion or exclusion. After a final validation, a core set of recommendations was translated into QIs. From 37 recommendations, obtained out of 10 international guidelines, and 5 existing indicators, a core set of 18 recommendations and 2 QIs was derived after the rating procedure. The expert panel added one new recommendation. Together, the recommendations and QIs were translated and merged into a final set of 21 QIs. Our study developed a set of 21 evidence-based and EHR-extractable QIs for COPD in primary care. These indicators can be used in an automated quality assessment to measure and improve the quality of COPD primary care.
A cross-sectional MR study of body fat volumes and distribution in chronic schizophrenia
Authors: Osimo Emanuele F. , Brugger Stefan P. , Thomas E. Louise , Howes Oliver D.
Published: March 2022

People with schizophrenia show higher risk for abdominal obesity than the general population, which could contribute to excess mortality. However, it is unclear whether this is driven by alterations in abdominal fat partitioning. Here, we test the hypothesis that individuals with schizophrenia show a higher proportion of visceral to total body fat measured using magnetic resonance imaging (MRI). We recruited 38 participants with schizophrenia and 38 healthy controls matched on age, sex, ethnicity, and body mass index. We found no significant differences in body fat distribution between groups, suggesting that increased abdominal obesity in schizophrenia is not associated with altered fat distribution.
A contrastive learning approach for ICU false arrhythmia alarm reduction
Authors: Zhou Yuerong , Zhao Guoshuai , Li Jun , Sun Gan , Qian Xueming , Moody Benjamin , Mark Roger G. , Lehman Li-wei H.
Published: March 2022

The high rate of false arrhythmia alarms in Intensive Care Units (ICUs) can lead to disruption of care, negatively impacting patients’ health through noise disturbances, and slow staff response time due to alarm fatigue. Prior false-alarm reduction approaches are often rule-based and require hand-crafted features from physiological waveforms as inputs to machine learning classifiers. Despite considerable prior efforts to address the problem, false alarms are a continuing problem in the ICUs. In this work, we present a deep learning framework to automatically learn feature representations of physiological waveforms using convolutional neural networks (CNNs) to discriminate between true vs. false arrhythmia alarms. We use Contrastive Learning to simultaneously minimize a binary cross entropy classification loss and a proposed similarity loss from pair-wise comparisons of waveform segments over time as a discriminative constraint. Furthermore, we augment our deep models with learned embeddings from a rule-based method to leverage prior domain knowledge for each alarm type. We evaluate our method using the dataset from the 2015 PhysioNet Computing in Cardiology Challenge. Ablation analysis demonstrates that Contrastive Learning significantly improves the performance of a combined deep learning and rule-based-embedding approach. Our results indicate that the final proposed deep learning framework achieves superior performance in comparison to the winning entries of the Challenge.
Optimization of an O2-balanced bioartificial pancreas for type 1 diabetes using statistical design of experiment
Authors: Mouré Anne , Bekir Sawsen , Bacou Elodie , Pruvost Quentin , Haurogné Karine , Allard Marie , De Beaurepaire Laurence , Bosch Steffi , Riochet David , Gauthier Olivier , Blancho Gilles , Soulillou Jean-Paul , Poncelet Denis , Mignot Grégoire , Courcoux Philippe , Jegou Dominique , Bach Jean-Marie , Mosser Mathilde
Published: March 2022

A bioartificial pancreas (BAP) encapsulating high pancreatic islets concentration is a promising alternative for type 1 diabetes therapy. However, the main limitation of this approach is O2supply, especially until graft neovascularization. Here, we described a methodology to design an optimal O2-balanced BAP using statistical design of experiment (DoE). A full factorial DoE was first performed to screen two O2-technologies on their ability to preserve pseudo-islet viability and function under hypoxia and normoxia. Then, response surface methodology was used to define the optimal O2-carrier and islet seeding concentrations to maximize the number of viable pseudo-islets in the BAP containing an O2-generator under hypoxia. Monitoring of viability, function and maturation of neonatal pig islets for 15 days in vitro demonstrated the efficiency of the optimal O2-balanced BAP. The findings should allow the design of a more realistic BAP for humans with high islets concentration by maintaining the O2balance in the device.
Cold plasma enamel surface treatment to increase fluoride varnish uptake
Authors: Fathollah S. , Abbasi H. , Akhoundi S. , Naeimabadi A. , Emamjome S.
Published: March 2022

Among the available methods of enamel strengthening, fluoride varnish (FV) treatment has relatively better results. On the other hand, cold plasma technology has shown promising capacities in sterilizing the environment, surface modification, and improving adhesion. Accordingly, this study aimed to increase the adhesion of FV to the enamel surface to prolong the enamel interaction with FV with subsequently increased fluoride uptake by enamel. Emphasizing that the change in adhesion is evidence-based and has not been explicitly measured. For this purpose, we randomly divided twenty bovine teeth into two groups A (consisting of four teeth) and B (composed of four subgroups, each containing four teeth). Samples of group A and one specimen of each subset B investigated the effect of using Helium-DBD (He-DBDJ), Argon (ArJ), and Air-DBD jet on the enamel surface. Other B specimens are devoted to studying the release of FV fluoride ions from processed enamel. Two diagnostic techniques, scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDS), have been utilized to examine the samples' surface morphology and chemical analysis, respectively. Finally, the release of fluoride ions into distilled water was measured by an ion-selective electrode (ISE). SEM images showed that ArJ and Air-DBD significantly damaged enamel hexagonal structures, whereas, in the case of He-DBDJ, the hexagonal structures have only altered from convex to concave. EDX indicated an increase in calcium to phosphorus ratio and the amount of fluoride and sodium uptake on the enamel surface layer in the group processed with He-DBDJ plasma. The latter helps restore the damaged parts of the enamel. Analysis of fluoride released from the FV did not show a significant change owing to plasma processing (P ≤ 0.112). The combination of cold plasma and fluoride varnish treatment on the enamel surface might be considered as a more promising approach to increasing enamel resistance to tooth decay.