bluuebunny/crossref_metadata_2025 huggingface dataset:
ChemInform Abstract: Tandem Cleavage of 2,3,5‐Trimethyl 7‐Trifluoroacetyl‐1,2,3,4‐tetrahydropyrrolo[1,2‐c]pyrimidine by Activated Alkynes, Caused by Michael Addition of a Tertiary Nitrogen Atom to a Triple Bond.
Authors: Voskressensky L. G. , Borisova T. N. , Kulikova L. N. , Varlamov A. V.
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Oxidative Free Radical Reactions Between 2‐Amino‐1,4‐benzoquinones and Carbonyl Compounds.
Authors: Chang Che‐Ping , Tsai An‐I
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Indole‐Derived Arynes and Their Diels—Alder Reactivity with Furans.
Authors: Buszek Keith R. , Luo Diheng , Kondrashov Mikhail , Brown Neil , VanderVelde David
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Sydnone Cycloaddition Route to Pyrazole Boronic Esters.
Authors: Browne Duncan L. , Helm Matthew D. , Plant Andrew , Harrity Joseph P. A.
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Highly Functionalized 2‐(Substituted Biphenyl) Benzimidazole via Suzuki—Miyaura Cross Coupling Reaction.
Authors: Vinodkumar Ramanatham , Rajagopal Kotarkonda , Devanna Nayakanti
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Novel One‐Pot Three‐Step Reaction Using Supported Reagents System: Synthesis of 2‐Aminothiazoles.
Authors: Aoyama Tadashi , Murata Sumiko , Takido Toshio , Kodomari Mitsuo
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Conjugated Compounds Based on Vinylthiazole Units.
Authors: Meier Herbert , Nicklas Frank , Petermann Ralf
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Simple and Efficient Synthesis of Novel N,N′‐Bis (1H‐Pyrrol‐1‐yl)‐1‐ [2‐(2‐aryl‐5‐methyl‐3‐oxo‐2,4‐dihydro‐3H‐1,2,4‐triazol‐4‐yl)ethyl] ‐1H‐1,2,3‐triazole‐4,5‐dicarboxamides.
Authors: Latthe Prashant R. , Sunagar Vinay A. , Badami Bharati V.
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A New Method for the Synthesis of Bicyclic Pyran Acetals.
Authors: Ergunes Duygu , Kumbaraci Volkan , Karliga Bekir , Talinli Naciye
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Lewis Acid Mediated Reactions of 1‐Cyclopropyl‐2‐arylethanones with Allenic Esters: A Facile Synthetic Protocol for the Preparation of Dihydrofuro[2,3‐h]chromen‐2‐one Derivatives.
Authors: Shi Min , Tang Xiang‐Ying , Yang Yong‐Hua
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Rapid and Efficient Microwave Assisted Method for the Regioselective Synthesis of 8,8′‐Methylene‐bis‐4‐oxo‐1H and 2H‐Chromeno[4,3‐c]pyrazoles.
Authors: Nagaraj Adki , Reddy Cherkupally Sanjeeva
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of N‐Benzoylamino‐1,2,3,6‐tetrahydropyridine Derivatives (I) as Potential Antiinflammatory Agents
Authors: Mochona Bereket , Redda Kinfe K.
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Hyperstrong Neutral Organic Bases: Phosphazeno Azacalix[3](2,6)pyridines.
Authors: Despotovic I. , Kovacevic B. , Maksic Z. B.
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Heterocyclic ortho‐Aminocarbonyl Compounds in the Friedlaender Reaction Promoted by Chlorotrimethylsilane.
Authors: Ryabukhin Sergey V. , Plaskon Andrey S. , Naumchik Vasiliy S. , Volochnyuk Dmitriy M. , Pipko Sergey E. , Tolmachev Andrey A.
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: 4‐Hydroxy‐2‐quinolones. Part 121. Synthesis and Biological Properties of 1‐Hydroxy‐3‐oxo‐5,6‐dihydro‐3H‐pyrrolo[3,2,1‐ij]quinoline‐2‐carboxylic Acid Alkylamides.
Authors: Ukrainets I. V. , Bereznyakova N. L. , Mospanova E. V.
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: 4‐Hydroxy‐2‐quinolones. Part 123. Amidation of 2‐Bromomethyl‐5‐oxo‐1,2‐dihydro‐5H‐oxazolo[3,2‐a]quinoline‐4‐carboxylic Acid.
Authors: Ukrainets I. V. , Bereznyakova N. L. , Turov A. V. , Shishkina S. V.
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Enamines of the 1,2,3,4‐Tetrahydroisoquinoline Series in the Chichibabin Synthesis of Pyrrolo[2,1‐a]isoquinolines and in Reaction with Oxalyl Chloride.
Authors: Polygalova N. N. , Mikhailovskii A. G. , Vikhareva E. V. , Vakhrin M. I.
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Convenient One‐Pot Synthesis of Multisubstituted Tetrahydropyrimidines via Catalyst‐Free Multicomponent Reactions.
Authors: Zhang Min , Jiang Huanfeng , Liu Hailing , Zhu Qiuhua
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Properties of Methyl Hydropyrimidineacetates.
Authors: Brokaite K. , Mickevicius V. , Mikulskiene G.
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Green Synthesis of Fused Pyrimido Derivatives in Aqueous Medium.
Authors: Kidwai Mazaahir , Singhal Kavita
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Microwave‐Assisted Efficient Synthesis of Benzo[4,5]imidazo[1,2‐a]pyrimidine Derivatives in Water under Catalyst‐Free Conditions.
Authors: Tu Shujiang , Shao Qingqing , Zhou Dianxiang , Cao Longji , Shi Feng , Li Chunmei
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis, Crystal and Molecular Structure of 2‐(3‐Chloropropyl)‐6‐methyl‐4‐phenylquinazoline 3‐Oxide (III).
Authors: Kulikov O. V. , Mazepa A. V.
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Mannich Reaction in the Synthesis of N,S‐Containing Heterocycles. Part 3. Unexpected Direction of the Aminomethylation Reaction of N‐Methylmorpholinium 1‐Amino‐2,4‐dicyano‐4‐ethoxycarbonyl‐1,3‐butadienethiolate. One Stage Cascade Synthesis of New Derivatives of Pyrido[1,2‐a][1,3,5]triazine.
Authors: Dotsenko V. V. , Krivokolysko S. G. , Rusanov E. B. , Gutov A. V. , Litvinov V. P.
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Denitrocyclization in Synthesis of Dibenzo[b,f][1,4]thiazepin‐11(10H)‐ones and Their Derivatives.
Authors: Smirnov Alexey V. , Kalandadze Levan S. , Sakharov Vladimir N. , Dorogov Mikhail V. , Ivachtchenko Alexander V.
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Metal‐Catalyzed Silylene Insertions of Allylic Ethers: Stereoselective Formation of Chiral Allylic Silanes.
Authors: Bourque Laura E. , Cleary Pamela A. , Woerpel K. A.
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Catalytic Asymmetric Synthesis of Allylsilanes Through Rhodium/Chiral Diene‐Catalyzed 1,4‐Addition of Alkenyl[2‐(hydroxymethyl)phenyl]dimethylsilanes.
Authors: Shintani Ryo , Ichikawa Yoshitaka , Hayashi Tamio , Chen Jinshui , Nakao Yoshiaki , Hiyama Tamejiro
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Organocatalytic Asymmetric Direct Phosphonylation of α,β‐Unsaturated Aldehydes: Mechanism, Scope, and Application in Synthesis.
Authors: Maerten Eddy , Cabrera Silvia , Kjaersgaard Anne , Joergensen Karl Anker
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Novel Organic Dyes Containing Coumarin Moiety for Solar Cell.
Authors: Choi Hyunbong , Baik Chul , Kim Hyun Jun Kim Hyun Jun , Kim Jeum‐Jong , Song Kihyung , Kang Sang Ook , Ko Jaejung
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Apotirucallane and Tirucallane Triterpenoids from Cedrela sinensis.
Authors: Mitsui Kumiko , Saito Hiroaki , Yamamura Ryota , Fukaya Haruhiko , Hitotsuyanagi Yukio , Takeya Koichi
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Clerodane Diterpenoids and Flavonoids with NGF‐Potentiating Activity from the Aerial Parts of Baccharis gaudichaudiana.
Authors: Guo Yuanqiang , Li Yushan , Xu Jing , Li Ning , Yamakuni Tohru , Ohizumi Yasushi
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Enantioselective Synthesis and Vanilloid Activity Evaluation of 1‐β‐(p‐Methoxycinnamoyl)polygodial (I), an Antinociceptive Compound from Drymis winteri Barks.
Authors: Della Monica Carmela , De Petrocellis Luciano , Di Marzo Vincenzo , Landi Raffaella , Izzo Irene , Spinella Aldo
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Pyrrolidinone‐Modified Di‐ and Tripeptides: Highly Diastereoselective Preparation and Investigation of Their Stability.
Authors: Hosseini Masood , Tanner David , Murray Anthony , Toender Janne E.
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Revisiting the Armed—Disarmed Concept: The Importance of Anomeric Configuration in the Activation of S‐Benzoxazolyl Glycosides.
Authors: Crich David , Li Ming
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of C‐Aryl‐nucleosides and O‐Aryl‐glycosides via Cuprate Glycosylation.
Authors: Hainke Sven , Singh Ishwar , Hemmings Jennifer , Seitz Oliver
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Intramolecular Nitrone—Olefin Cycloaddition of D‐Glucose‐Derived Allylic Alcohol: Synthesis of New Aminocyclohexitols.
Authors: Chakraborty Chaitali , Vyavahare Vinod P. , Dhavale Dilip D.
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Diterpenoid Alkaloids of Delphinium buschianum Grossh.
Authors: Bitis Leyla , Suezgec Sevda , Soezer Ulas , Oezcelik Hasan , Zapp Josef , Kiemer Alexandra K. , Mericli Filiz , Mericli Ali H.
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Chamobtusin A, a Novel Skeleton Diterpenoid Alkaloid from Chamaecyparis obtusa cv. tetragon.
Authors: Zhang Yu‐Mei , Tan Ning‐Hua , Lu Yang , Chang Ying , Jia Rui‐Rui
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Asymmetric Synthesis of (‐)‐1‐Hydroxyquinolizidinone, a Common Intermediate for the Syntheses of (‐)‐Homopumiliotoxin 223G and (‐)‐Epiquinalide.
Authors: Voituriez Arnaud , Ferreira Franck , Perez‐Luna Alejandro , Chemla Fabrice
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The First Direct C—H Arylation of Purine Nucleosides.
Authors: Cerna Igor , Pohl Radek , Hocek Michal
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Expanded Fluorescent Nucleoside Analogue as Hybridization Probe.
Authors: Seo Young Jun , Bhuniya Sankarprasad , Tapadar Subhasish , Yi Jeong Wu , Kim Byeang Hyean
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Studies Directed Towards the Stereoselective Total Synthesis of Ilexlactone via a Tandem Ring‐Closing Enyne Metathesis Protocol
Authors: Krishna Palakodety Radha , Narsingam M.
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Differentiation of Nonconventional “Carbanions” — The Total Synthesis of Nemorosone (I) and Clusianone (II).
Authors: Tsukano Chihiro , Siegel Dionicio R. , Danishefsky Samuel J.
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Asymmetric Syntheses of Diarylheptanoid Natural Products (‐)‐Centrolobine and (‐)‐De‐O‐methylcentrolobine via Hetero‐Diels—Alder Reaction Cataylzed by Dirhodium(II) Tetrakis[(R)‐3‐(benzene‐fused‐phthalimido)‐2‐piperidinonate].
Authors: Washio Takuya , Yamaguchi Reika , Abe Takumi , Nambu Hisanori , Anada Masahiro , Hashimoto Shunichi
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: First Total Syntheses of (.+‐.)‐Penicillones A and B.
Authors: Hsu Day‐Shin , Liao Chun‐Chen
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: An Unusual Picoline Derivative from the Trifluoroacetolysis of Thiostrepton.
Authors: Merritt Eleanor A. , Bagley Mark C.
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Three‐Dimensional Atomic‐Scale Structure of Size‐Selected Gold Nanoclusters.
Authors: Li Z. Y. , Young N. P. , Di Vece M. , Palomba S. , Palmer R. E. , Bleloch A. L. , Curley B. C. , Johnston R. L. , Jiang J. , Yuan J.
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Application of Electron Backscatter Diffraction to the Study of Phase Transformations
Authors: Gourgues‐Lorenzon A. F.
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Carboranyl Thymidine Analogues for Neutron Capture Therapy
Authors: Tjarks Werner , Tiwari Rohit , Byun Youngjoo , Narayanasamy Sureshbabu , Barth Rolf F.
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Novel 2′‐Deoxy Type trans‐3′,4′‐Bridged Nucleic Acid
Authors: Osaki Tomohisa , Obika Satoshi , Harada Yasuki , Mitsuoka Yasunori , Sugaya Kensaku , Sekiguchi Mitsuaki , Roongjang Somjing , Imanishi Takeshi
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Furano‐ and Pyrrolo[2,3‐d]pyrimidine Nucleosides and Their 5′‐O‐Triphosphates: Synthesis and Enzymatic Activity
Authors: Alexandrova L. A. , Ivanov M. A. , Victorova L. S. , Kukhanova M. K.
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Synthesis and Properties of Tricyclic Analogues of S6‐Methylthioguanine and O6‐Methylguanine
Authors: Hornillo‐Araujo Ana R. , Burrell Adam J. M. , Aiertza Miren K. , Shibata Takayuki , Hammond David M. , Edmont Dolores , Adams Harry , Margison Geoffrey P. , Williams David M.
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Stereospecific Synthesis of (‐)‐Neplanocin F
Authors: Rodriguez Ropero Sergio , Edmont Dolores , Mathe Christophe , Perigaud Christian
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Revisited 3′‐Deoxy‐3′‐C‐methyl‐β‐D‐ribonucleoside Series
Authors: Aljarah Mohamed , Couturier Sarah , Gosselin Gilles , Mathe Christophe , Perigaud Christian
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Primary Evaluation of Novel HIV‐1 Inhibitors
Authors: El Safadi Yazan , Marquet Roland , Aubertin Anne‐Marie , Vivet‐Boudou Valerie
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Cyclopentane‐Nucleobase Coupling in the Synthesis of Carbocyclic L‐Nucleosides: Is a SN2‐Reaction an Alternative to the Mitsunobu‐Reaction ?
Authors: Jessel S. , Hense E. , Meier C.
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of a Fluorescent PNA Monomer Containing 5‐((9H‐Fluoren‐2‐yl)ethynyl)uracil
Authors: Wojciechowski Filip , Hudson Robert H. E.
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Modified Nucleosides for Incorporation of Formyletheno and Carboxyetheno Adducts of Adenine Nucleosides into Oligonucleotides
Authors: Koissi Niangoran , Loennberg Harri
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Insect Pheromone Synthesis in Brazil
Authors: Zarbin Paulo H. G. , Villar Jose A. F. P. , Correa Arlene G.
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Antiinfluenza Virus Agents: Synthesis and Mode of Action
Authors: Lagoja Irene M. , De Clercq Erik
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: HIV‐1 Integrase Inhibitors: 2005—2006 Update
Authors: Dayam Raveendra , Gundla Rambabu , Al‐Mawsawi Laith Q. , Neamati Nouri
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: anti‐Mitotic Activity of Colchicine and the Structural Basis for Its Interaction with Tubulin
Authors: Bhattacharyya Bhabatarak , Panda Dulal , Gupta Suvroma , Banerjee Mithu
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Sulfur Containing Acyclovir Derivatives: Synthesis, Cytotoxic Activity, and Cell Phenotype Studies
Authors: Ikaunieks Martins , Shestakova Irina , Domracheva Ilona , Belyakov Sergey , Madre Marina
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of 9‐(2,3‐Dideoxy‐2,3‐difluoro‐β‐D‐arabinofuranosyl)adenine
Authors: Sivets Grigorii G. , Kalinichenko Elena N. , Mikhailopulo Igor A.
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Geometric Formalism for DNA Quadruplex Folding
Authors: Webba da Silva Mateus
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Cellular Targets of Natural Products
Authors: Dixon Neil , Wong Lu Shin , Geerlings Torsten H. , Micklefield Jason
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Structural Biology in Plant Natural Product Biosynthesis—Architecture of Enzymes from Monoterpenoid Indole and Tropane Alkaloid Biosynthesis
Authors: Stoeckigt Joachim , Panjikar Santosh
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Applications of Molecularly Imprinted Polymers in Analytical and Pharmaceutical Chemistry
Authors: Lachova M. , Lehotay Jozef , Cizmarik J.
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
New practical synthesis of Tamsulosin
Authors: Gizur T. , Fogassy E. , Bálint J. , Egri G. , Törley J. , Demeter Á. , Greiner I.
Published: February 2008

The medicine called Tamsulosin was produced 25 years ago and since then almost 10 new synthesis route has been known. Each process shows the researchers' workstyle, every year, which mainly differs in the way of separating the enantiomers. The applied reaction steps also reflect the development over the past 25 years and the new synthesis is influenced by the antecedents. The key‐intermediate used in our new method is a racemic secondary amine derivative, which is unknown in the literature before and for resolving it, we worked out a quite advantegeous process. By using an optically active secondary amine, side reactions can be avoided. Chirality, 2008. © 2008 Wiley‐Liss, Inc.
Guest‐dependent conformation of 18‐crown‐6 tetracarboxylic acid: Relation to chiral separation of racemic amino acids
Authors: Nagata Hiroomi , Nishi Hiroyuki , Kamigauchi Miyoko , Ishida Toshimasa
Published: February 2008

(+)‐18‐Crown‐6 tetracarboxylic acid (18C6H4) has been used as a chiral selector for various amines and amino acids. To further clarify the structural scaffold of 18C6H4 for chiral separation, single crystal X‐ray analysis of its glycine+ (1), H3O+ (2), H5O (3), NH (4), and 2CH3NH (5) complexes was performed and the guest‐dependent conformation of 18C6H4 was investigated. The crown ether ring of 18C6H4 in 3, 4, and 5 took a symmetrical C2 or C2‐like conformation, whereas that in 1 and 2 took an asymmetric C1 conformation, which is commonly observed in complexes with various optically active amino acids. The overall survey of the present and related complexes suggests that the molecular conformation of 18C6H4 is freely changeable within an allowable range, depending on the molecular shape and interaction mode with the cationic guest. On the basis of the present results, we propose the allowable conformational variation of 18C6H4 and a possible transition pathway from its primary conformation to the conformation suitable for chiral separation of racemic amines and amino acids. Chirality, 2008. © 2008 Wiley‐Liss, Inc.
Materialschonendes Hochdruckdispergieren mit dem High Pressure Post Feeding (HPPF)‐System
Authors: Sauter C. , Schuchmann H. P.
Published: February 2008

Die Herstellung nanoskaliger Dispersionen in Hochdrucksystemen ist zurzeit aufgrund der oftmals abrasiv wirkenden Materialien durch einen hohen Verschleiß der Dispergierdüsen und daraus entstehenden hohen Kosten und kurzen Standzeiten der Anlage gekennzeichnet. Das in dieser Arbeit vorgestellte High Pressure Post Feeding (HPPF)‐System ermöglicht eine Dispergierung und Desagglomeration auch abrasiver Nanopartikel nahezu ohne Nutzungsschäden. Die Hochdruckdüsen werden hierbei so ausgelegt, dass die abrasiv wirkenden Partikel nicht die Düse passieren, sondern direkt nach der Düse dem zerkleinerungswirksamen, hoch turbulenten Bereich zugeführt werden. Im Vergleich mit einem Standardhochdrucksystem zum Dispergieren und Desagglomerieren von Nanopartikeln zeigt das HPPF‐System mindestens gleiche Dispergierergebenisse. Der Einfluss verschiedener Anlagen‐ und Prozessparameter auf die Dispergier‐ und Desagglomerationseffizienz wird dargestellt und diskutiert.
Bioprozessanalytik
Authors: Rehbock C. , Beutel S. , Brückerhoff T. , Hitzmann B. , Riechers D. , Rudolph G. , Stahl F. , Scheper T. , Friehs K.
Published: February 2008

Bioprozessanalytik wird benötigt, um biotechnologische Prozesse detailliert beobachten zu können. Auf der Basis dieser Beobachtung lässt sich der Prozesszustand bestimmen und regeln. Gleichzeitig kann die Qualität des Prozesses und der einzelnen Produkte verfolgt werden. Für die industrielle Biotechnologie wird im Allgemeinen die passende Prozessanalytik im F&E‐Bereich auf ihre Aussagekraft getestet. Einzelne Prozessleitgrößen werden bestimmt, mit denen dann in der Produktion der Prozess gefahren werden kann. In den letzten zwei Jahren hat die Bioprozessanalytik im Bereich der industriellen Biotechnologie eine immense Aufmerksamkeit durch die Prozessanalysentechnik (PAT)‐Initiative der Food and Drug Administration (FDA) erhalten. Dahinter verbirgt sich das Bestreben, mit Hilfe geeigneter Prozessanalysentechnik einen geeigneten Rahmen für innovative, pharmazeutische Entwicklungen, Produktionen und Qualitätssicherung zu generieren. Dabei wird die PAT nicht als reine Prozessanalyse angesehen, sondern sie vereint chemische, physikalische, mikrobiologische, mathematische Aspekte und eine Risikoanalyse, bezogen auf den jeweiligen Prozess. Durch das bessere Prozessverständnis mittels PAT lassen sich dann Prozesse sicher steuern. Von besonderem Interesse ist bei der PAT, dass Einzelvalidierungen bei Änderungen im Gesamtprozess nicht mehr unbedingt nötig sind, wenn der Gesamtprozess/das Gesamtsystem über die PAT validiert wurde. Dieser Beitrag konzentriert sich auf einen Überblick über die moderne Bioprozessanalytik, wobei ein Schwerpunkt auf chemische und biologische Messgrößen gelegt wird.
Charakterisierung interpartikulärer Kräfte für Fest/Flüssig‐Trennverfahren mittels Analytischer Zentrifugation
Authors: Sobisch T. , Lerche D.
Published: February 2008

Das Verhalten von Dispersionen, gekennzeichnet durch Entmischungs‐, Fließ‐ und Packungsverhalten, wird durch Art und Stärke der interpartikulären Wechselwirkungskräfte bestimmt. Dies ist von grundlegender Bedeutung für die Anwendung von Dispersionen auf verschiedensten Gebieten aber auch für Fest/Flüssig‐Trennverfahren. Der folgende Beitrag berichtet über die Anwendung der Analytischen Zentrifugation zur Untersuchung der Kinetik und Polydispersität von Trennprozessen sowie des Packungs‐ und Kompressionsverhaltens am Beispiel polydisperser Feinstpartikelsuspensionen. Die Analytische Zentrifuge misst die lokalen und zeitlichen Änderungen der Transmission mittels STEP‐Verfahren. Innerhalb der untersuchten Feinstpartikelsuspensionen variiert der Grad der Partikelwechselwirkung von repulsiv bis stark attraktiv und deckt somit den gesamten Bereich typischer Trennaufgaben ab. Die Charakteristik der Trennprozesse (Einzelkorn‐ oder Zonensedimentation, freie oder behinderte Sedimentation, Konsolidierungsverhalten, Polydispersität) lässt sich aus der Form und dem Verlauf der gemessenen Transmissionsprofile bestimmen. Repulsive Partikelwechselwirkungen führen zu einem polydispersen Sedimentationsverhalten, d. h. die Teilchen sedimentieren mit unterschiedlicher Geschwindigkeit entsprechend ihrer Größe. Im Fall stark attraktiver Wechselwirkungen bewegen sich insbesondere bei hohen Volumenkonzentrationen alle Partikel gemeinsam mit dergleichen Geschwindigkeit. Wenn nur schwache Anziehungskräfte wirken, bildet sich eine Sedimentationsfront, die den Großteil der Partikel einschließt, ein Teil der kleineren Partikel zeigt aber weiterhin polydisperses Sedimentationsverhalten. Die erzielbare Packungsdichte wird gleichfalls durch die Stärke der Partikelwechselwirkungen bestimmt. Aus technologischer Sicht steht die Packungsdichte im direkten Zusammenhang mit der Entwässerbarkeit bzw. dem Entfeuchtungsverhalten sowie der Redispergierbarkeit. Für kolloidchemisch stabile Dispersionen (repulsive Wechselwirkungen) werden auch bei relativ geringer Zentrifugalbeschleunigung hohe Packungsdichten erreicht, die Sedimente sind nahezu inkompressibel. Bei polydispersen Systemen tritt in diesem Fall Partikelsegregation auf. Mit Zunahme der Anziehungskräfte zwischen den Teilchen ist ausgeprägtes Kompressionsverhalten zu beobachten, die Packungsdichte ist stark vom ausgeübten Zentrifugaldruck abhängig. Bei stark geflockten Systemen werden selbst bei sehr hohen Drücken nur moderate Entfeuchtungsgrade erzielt.
Expression of the nuclear export protein chromosomal region maintenance/exportin 1/Xpo1 is a prognostic factor in human ovarian cancer
Authors: Noske Aurelia , Weichert Wilko , Niesporek Silvia , Röske Annika , Buckendahl Ann‐Christin , Koch Ines , Sehouli Jalid , Dietel Manfred , Denkert Carsten
Published: February 2008

BACKGROUND

The human nuclear export protein chromosomal region maintenance/exportin 1/Xpo1 (CRM1) mediates the nuclear export of proteins and messenger RNAs and, thus, is an important regulator of subcellular distribution of key molecules. Whereas cell‐biologic studies have suggested a fundamental role for CRM1 in the regulation of mitosis, the expression of this protein in human tumor tissue has not been investigated to date.

METHODS

In this study, the expression of CRM1 was analyzed in a cohort of 88 ovarian tumors and 12 ovarian cell lines for the first time to the authors' knowledge.

RESULTS

Immunohistochemistry revealed increased nuclear (52.7%) and cytoplasmic (56.8%) expression of CRM1 in 74 carcinomas compared with the expression revealed in borderline tumors and benign lesions. Similarly, CRM1 expression was increased in ovarian cancer cell lines compared with human ovarian surface epithelial cells. Cytoplasmic CRM1 expression was related significantly to advanced tumor stage (P = .043), poorly differentiated carcinomas (P = .011), and higher mitotic rate (P = .008). Nuclear CRM1 was associated significantly with cyclooxygenase‐2 (COX‐2) expression (P = .002) and poor overall survival (P = .01). Because it was demonstrated previously that blocking of CRM1 by leptomycin B (LMB) contributes to the inhibition of nuclear export, the authors used a set of mechanistic assays to study the effects of CRM1 inhibition in cancer cells. Treatment of OVCAR‐3 cells with LMB revealed a significant reduction of cell proliferation and increased apoptosis as well as suppressed interleukin‐1β‐induced COX‐2 expression.

CONCLUSIONS

The current results indicated that CRM1 is expressed in a subpopulation of ovarian carcinomas with aggressive behavior and is related to poor patient outcome. A correlation also was demonstrated between CRM1 and COX‐2 expression in ovarian cancer tissue. Furthermore, the treatment of ovarian cancer cells with LMB revealed a reduction in COX‐2 expression. Therefore, the authors suggest that CRM1 may be an interesting biomarker for the assessment of patient prognosis and a molecular target for anticancer treatment. Cancer 2008. © 2008 American Cancer Society.
Age and gender are significant independent predictors of survival in primary cutaneous melanoma
Authors: Lasithiotakis Konstantinos , Leiter Ulrike , Meier Friedegund , Eigentler Thomas , Metzler Gizela , Moehrle Matthias , Breuninger Helmut , Garbe Claus
Published: February 2008

BACKGROUND

The aim was to identify age‐ related and gender‐related differences in the clinical presentation and outcome of patients with primary cutaneous melanoma (CM).

METHODS

A total of 4785 CM patients without clinical evidence of metastasis diagnosed during the period 1976–2001 in southern Germany included in the analysis. Kaplan‐Meier analyses were performed to estimate and to compare disease‐specific survival (DSS) and survival after first recurrence (SAR). The Cox proportional hazards model was used to evaluate the effect of multiple variables on DSS and SAR.

RESULTS

Increasing age and male gender were independently associated with thicker tumors (>2 mm) and histologic ulceration (P < .001). Patients older than 65 years had lower 10‐year DSS than younger patients (81.8% vs 88.4%, P < .001) and this difference was more pronounced in women (P < .001) than in men (P = .06). Males had lower 10‐year DSS than females (83.5% vs 88.5%, P < .001) but this difference did not reach statistical significance in patients older than 65 years (P = .162). In multivariate analysis adjusted for tumor thickness, ulceration, anatomic site, histologic subtype, DSS, site of first recurrence, time trend, sentinel lymph node status, age, and gender were independent predictors of DSS and SAR (P < .05).

CONCLUSIONS

Older age and male gender are associated with prognostically unfavorable primary CM. Expansion of current preventive strategies to target these subgroups is warranted. Moreover, age and gender are independent predictors of the outcome of CM patients. Females have a better prognosis than males but this difference disappears after the age of 65. Younger patients have a more favorable prognosis than older patients, a difference more pronounced in women. Cancer 2008. © 2008 American Cancer Society.