bluuebunny/crossref_metadata_2025 huggingface dataset:
Histórias em Quadrinhos sobre a pandemia Covid-19 como divulgação científica nas redes sociais da Casa da Descoberta
Authors: Ferro Mylenna Vieira , Ribeiro Carlos Magno Rocha
Published: February 2022

Objetivo: este trabalho busca descrever a utilização de histórias em quadrinhos (HQs) sobre temas relacionados à pandemia Covid-19, como meio de divulgação científica nas redes sociais, facebook e instagram da Casa Descoberta (CD), um centro de divulgação científica da Universidade Federal Fluminense. Metodologia: Inicialmente elaborou-se um questionário diagnóstico para perceber os temas relacionados à Química e Ciência com a pandemia Covid-19 que o público em geral estaria interessado em conhecer. O questionário foi encaminhado em setembro de 2020 via googleform através da rede social. Considerando as respostas de 51 pessoas, elaborou-se 10 HQs animadas que foram publicadas no facebook e instagram da CD de novembro de 2020 a março de 2021. Os temas abordados foram desde álcool gel, materiais de limpeza, sabão e saneantes, sobre Coronavirus, testes para o Covid-19, importância das vacinas, história das pandemias até tipos de vacinas. Para a produção das HQs, primeiramente elaborou-se os storylines e roteiros, até a produção final utilizando o aplicativo Canva®, sempre baseados em informações científicas, que foram referenciadas antes dos créditos das HQs. Visando ser um produto atrativo e dinâmico e atendendo às características dos meios de comunicações, as HQS foram animadas para o facebook e na forma de post para o instagram contendo cerca de 10 quadros. Os personagens usados foram as mascotes da CD que dialogavam entre si e diretamente com o público. Resultados: Através dos números de likes, visualizações e compartilhamentos, além dos comentários do público, percebeu-se a importância e interesse das pessoas neste tipo de abordagem e meio de divulgação científicao. Conclusão: foi possível observar que as HQs podem ser um instrumento lúdico e importante de divulgação científica.
Percepção do ruído e seus efeitos em funcionários de um hospital universitário
Authors: Passos Priscila Silva , Fiorini Ana Claudia
Published: February 2022

Introdução: Funcionários de hospitais são expostos ao ruído proveniente de diversas fontes. Objetivo: Investigar a percepção e os efeitos do ruído em funcionários de um hospital universitário no município de Lagarto-SE. Método: Estudo observacional de corte transversal realizado com 170 funcionários. Foram aplicados anamnese e questionário de incômodo ao ruído, adaptado para o ambiente hospitalar. Níveis de ruído foram medidos nos turnos diurno e noturno. Foram encontrados valores de Leq entre 66,1 e 79 dB(A), com níveis mais elevados no turno diurno. Para análise dos dados foi realizada aplicação de testes qui-quadrado de independência e ajustes de modelos de regressão logística. Resultados: A maioria dos profissionais era do sexo feminino (69,4%), com idade média de 38 anos. A maioria (54,1%) considerou o local repetidamente ou sempre ruidoso e 85,9% classificaram a intensidade moderada ou intensa. O período da manhã foi considerado o mais ruidoso. A fonte de ruído mais citada foram os profissionais. A maioria (97,1%) acredita que o ruído no hospital pode prejudicar o paciente e 79,4% acredita que estratégias podem minimizar esta exposição, sendo a mais sugerida a realização de ações de conscientização aos profissionais (63%). Conclusão: Houve percepção quando a frequência, a intensidade e a queixas relacionadas ao ruído, por parte dos profissionais.
Projeto Conscientização para Conservação: ações ambientais em unidade de conservação na região do Marajó/PA
Authors: Araújo Alzira Almeida de , Pontes Altem Nascimento , Soares Cintia da Cunha , Souza Shislene Rodrigues de , Barbosa Adriele de Fátima de Lima , Andrade Marcia Tatiana Vilhena Segtowich , Santos Miguel Moraes dos , Silva Rodrigo Cardoso da
Published: February 2022

Este trabalho apresenta ações ambientais realizadas do projeto, intitulado, Conscientização para Conservação: Educação Ambiental no Parque Estadual Charapucu, sendo um projeto que surgiu por meio de planejamento de gestão do Instituto de Desenvolvimento Florestal da Biodiversidade do estado do Pará, tendo sua dinâmica pautada em ações que perpassam por comunidades tradicionais em unidade de conservação. O objetivo dar-se em sistematizar as ações que foram realizadas no Parque Estadual Charapucu, sendo uma Unidade de Conservação da Natureza de Proteção Integral localizada na Amazônia Paraense, na Ilha do Marajó, na cidade de Afuá. Metodologicamente essa pesquisa apresenta abrangência qualitativa por envolver estudos de ações sociais grupais, tratando-se de uma pesquisa-ação participativa, o projeto aborda palestras, ações educativas, gincanas, teatro de fantoches, jogos lúdicos pedagógicos, construção de horta suspensa entre outros. Conclui-se com o desenvolvimento do projeto quem vem possibilita alcançar públicos diversos, atualmente foram totalizadas aproximadamente 2.500 pessoas em 15 escolas na zona rural e urbana e 12 comunidades rurais, assim possibilitando trabalhar com escolas e comunidades em área de várzea, sendo um território de difícil acesso onde a exploração dos recursos naturais são a base de sustento das famílias locais.
Transtornos neurocognitivos e demência relacionados ao HIV em pessoas que fazem uso de antirretroviral: uma revisão integrativa
Authors: Silva Roni Robson da , Silva Leandro Andrade da , Silva Maria Virginia Godoy da , Araujo Michael Silva , Neves Milena Preissler das , Souza Marcus Vinicius Lessa de , Oliveira Elson Santos de , Silva Junior Milton Domingues da , Ribeiro Mônica Barreto
Published: February 2022

Distúrbios neurológicos e comprometimento cognitivo são comumente associados ao HIV. Embora o comprometimento neurocognitivo grave e progressivo tenha se tornado raro em clínicas de infectologia na era da terapia antirretroviral TARV potente, a maioria das PVHIV em todo o mundo apresenta desempenho abaixo das expectativas em testes neurocognitivos formais. Objetivo: Evidenciar os efeitos do HIV associado ao comprometimento neurocognitivo. Método: Trata-se de uma revisão integrativa da literatura que seguiu a estratégia PICO para identificar os fatores associados ao Transtorno Neurocognitivo relacionados ao HIV. A busca dos artigos foi realizada em três bases de dados eletrônicas: Medline, Lilacs e Scielo. Foram utilizados os descritores “Complexo AIDS Demência”, “HIV”, “Sobreviventes de Longo Prazo ao HIV”, “Demência”, “Transtornos Neurocognitivos”, com textos completos, publicados no período de 2012 a 2022, no idioma inglês, português e espanhol e foi usado o operador booleano AND. Resultado: Foram encontrados 356 artigos. Vinte e cinco artigos foram selecionados para serem lidos na íntegra e 5 atenderam aos critérios desta revisão. Conclusão: As comorbidades contribuem para o comprometimento, mas são insuficientes para explicar a frequência do comprometimento encontrado. Os marcadores de doença do HIV, como a carga viral atual e a contagem de CD4, não estão mais fortemente associados ao comprometimento contínuo da terapia, enquanto os marcadores de doença cardiovascular e os marcadores inflamatórios parecem mais associados. Novos biomarcadores de líquido cefalorraquidiano e neuroimagem são necessários para detectar e acompanhar o comprometimento. Pesquisa em andamento para otimizar a terapia do HIV no sistema nervoso central, e potencialmente intervir nos mecanismos de neurotoxicidade a jusante continuam sendo importantes avenidas de investigação futura. Em última análise, o controle total do vírus no cérebro é um passo necessário para a erradicação do HIV.
Aspectos epidemiológicos do Lynxacarus radovskyi – Revisão de literatura
Authors: Souza Caio Cezar Nogueira de , Figueiredo Edigleise Costa , Vasconcelos Rafaela Sena , Meneses André Marcelo Conceição , Sousa Sinerey Karla Salim Aragão de
Published: February 2022

Enfermidades dermatológicas vêm ganhando cada vez mais destaque na rotina de clínicas e hospitais veterinários, e dentro desse contexto a linxacariose causada pelo ácaro Lynxacarus radovskyi tem apresentado uma ocorrência significativa em felinos domésticos. Dessa forma, o objetivo desse estudo é fazer uma revisão de literatura narrativa acerca desse agente, abordando a epidemiologia, métodos diagnósticos e tratamento. Por fim, considera-se que o intuito principal do estudo foi alcançado, tratando-se de um agente que não é comumente encontrado em animais domésticos, contudo é de extrema importância o conhecimento acerca de suas causas, epidemiologia, protocolos terapêuticos e profilaxia a fim de controlar sua prevalência e as taxas de infecção em seus hospedeiros.
Produção de maltodextrina em secador por atomização e em SRRI : impactos da temperatura de transição vítrea
Authors: Ikeda Siegrid Kopp , Finzer José Roberto Delalibera
Published: February 2022

As maltodextrinas são produtos da hidrólise parcial do amido. São classificadas de acordo com o grau de hidrólise do amido e possuem várias propriedades funcionais, como doçura, solubilidade e viscosidade. A variação da densidade final do produto pode não atender à especificação de empresas consumidoras. Isto ocasiona problemas no armazenamento do produto acabado e um possível risco de segurança no armazenamento. A decisão de avaliar o controle de qualidade de maltodextrina amadureceu após a constatação de que a densidade final tem um impacto no armazenamento e no atendimento dos clientes. Este trabalho tem por objetivo verificar a influência dos parâmetros de secagem em spray dryer, na densidade aparente da maltodextrina, utilizando os dados de processos disponíveis e a temperatura de transição vítrea nas condições de operação do spray dryer. O estudo mostrou que entre os parâmetros quantificados, o vácuo aplicado no secador por atomização (spray dryer) influenciou na densidade aparente da maltodextrina e o secador deve operar com um vácuo médio de 44 mmCa, uma vez que os outros parâmetros de secagem apresentaram valores similares e, portanto, sem influência na densidade aparente. O valor da temperatura de transição vítrea (Tg) calculada para este sistema de secagem está entre 150,0°C a 150,8°C, a temperatura de saída da câmara do secador entre 106,12°C a 107,00°C e a temperatura de entrada do ar no secador entre 192,08°C a 196,43°C. A temperatura de operação interna do secador está abaixo da temperatura de transição vítrea do produto. Isso possibilita classificar o produto como no estado vítreo
Psychophysiological Responses to Laughter Yoga in Women: Two Studies on the Visual and Practice Effects of this New Physical Activity
Authors: Szabo Attila , Berkes Tímea , Ihász Ferenc , Köteles Ferenc
Published: February 2022

Laughter yoga is claimed to have similar psychological and physiological effects to exercising. The objectives of the two studies reported here were to examine the visual and practice effects of laughter yoga in women. Study 1 was performed with 13 young women (mean age =21.92 ± SD = 1.66 years) who only experienced laughter yoga visually. Study 2 investigated 25 older women (mean age = 63.83 ± SD = 11.91 years) during an in-situ laughter yoga class. There was no relationship between the humor styles, expectancy, and the magnitude of change in psychological measures, neither in visual nor in the practice experience of laughter yoga. In Study 1, negative affect decreased while feeling states, heart rate, and respiration rate increased because of watching laughter yoga. In Study 2, feeling states, felt arousal, positive affect, and negative affect improved after the class. Even more intriguingly, heart rate also increased, and the basic metabolic rate during the class was comparable to that of light to moderate physical activity. As laughter yoga is characterized by positive psychological and cardiometabolic changes, it could represent a pleasurable, healthy, and secure form of recreation for all, but based on the current results, especially for older women.  

Keywords: affect, exercise, humor, recreation, social.
Pengaruh Air Kelapa (Cocos nucivera) dan Bokashi Kirinyuh (Chromolaena odorata) terhadap Pertumbuhan Tanaman Sawi (Brassica juncea L.)
Authors: Sumardin Sumardin , Arif Norma , Bahrun Andi
Published: February 2022

Penelitian ini bertujuan untuk mengetahui pengaruh penyiraman air kelapa muda (Cocos nucivera)dan bokasi krinyuh (Chromolaenaodorata)terhadap pertumbuhan tanaman sawi(Brassica juncea L.).Penelitian ini disusun berdasarkan Rancangan Acak Kelompok (RAK) dalam pola faktorial yang terdiri dari 2 faktor.Faktor pertama adalah air kelapa muda yang terdiri atas 4 taraf: tanpa air kelapa (A0), air kelapa muda  100 ml polibag-1(A1),  150 ml polibag-1 (A2), 200 ml polibag-1 (A3). Faktor kedua adalah bokasi krinyuh yang terdiri atas 4 taraf yaitu tanpa bokasi  krinyuh (K0), bokasi krinyuh 75 gram polibag-1 (K1), bokasi krinyuh 100 gram polibag-1 (K2), bokasi krinyuh 125 gram polibag-1 (K3).Hasil penelitian menunjukan bahwa interaksi antara air kelapa muda dan bokasi krinyuh tidak berpengaruh terhadap semua variabel yang diamati: mulai dari tinggi tanaman, jumlah daun, luas daun, berat segar tanaman, berat segar akar, berat kering tanaman, berat kering akar. Perlakuan air kelapa muda secara mandiri berpengaruh sangat nyata terhadap variabel yang diamati yakni tinggi tanaman pada 16 HST dan berpengaruh nyata pada 28 HST, jumlah daun 16 HST dan luas daun 16 HST.Pemberian bokasi krinyuh memberikan pengaruh sangat nyata  terhadap semua variabel pertumbuhan tanaman sawi yakni tinggi tanaman 10, 16, 22, 28 HST,  jumlah daun 10, 16, 22, 28 HST, luas daun 10, 16, 22, 28 HST, berat segar tanaman, berat segar akar, berat kering tanaman,dan berat kering akar.Kata Kunci: Air kelapa muda, bokasi, krinyuh dan tanaman sawi.
EVALUASI PENERAPAN PSAK 102 TENTANG AKUNTANSI MURABAHAH PADA BANK BNI SYARIAH KANTOR CABANG MANDONGA
Authors: Abdullah Muntu , Fitriaman Fitriaman , Jabal Nur Muh
Published: February 2022

Penelitian ini bertujuan untuk mengetahui penerapan PSAK No. 102 tentang akuntansi murabahah mengenai pengakuan, pengukuran, penyajian, dan pengungkapan pada Bank BNI Syariah Kantor Cabang Mandonga. Data yang digunakan dalam penelitan ini adalah data sekunder, teknik pengumpulan data dengan wawancara, serta analisis data dalam penelitian ini adalah deskriptif kualitatif dan kuantitatif. Hasil penelitian ini menunjukkan bahwa pelaksanaan akuntansi pembiayaan murabahah pada Bank BNI Syariah Kantor Cabang Mandonga belum sepenuhnya diterapkan sesuai dengan PSAK No. 102 tentang akuntansi murabahah. hal ini dibuktikan dengan tidak adanya pengakuan denda dan murabahah tanpa pesanan yang dijalankan Bank BNI Syariah Kantor Cabang Mandonga
PENERAPAN ACTIVITY BASED COSTING SEBAGAI DASAR PENENTUAN TARIF JASA RAWAT INAP RSUD KOTA KENDARI
Authors: Dharmawati Tuti , Anto La Ode , Zaelani Nikita
Published: February 2022

Penelitian ini bertujuan untuk mengetahui dan menjelaskan penerapan atau perhitungan Activity Based Costing sebagai dasar penentuan tarif jasa rawat inap RSUD Kota Kendari. Jenis data dalam penelitian ini adalah data kuantitatif dan data kualitatif. Sumber data dalam penelitian ini adalah data primer dan data sekunder. Metode pengumpulan data dalam penelitian adalah metode wawancara dan metode dokumentasi. Penelitian ini menggunakan metode analisis data deskriptif.Hasil penelitian ini menunjukkan bahwa perhitungan tarif rawat inap dengan menggunakan Activity Based Costing, apabila dibandingkan dengan tarif rawat inap yang digunakan oleh RSUD Kota Kendari, terlihat bahwa perhitungan tarif menggunakan Activity Based Costing untuk kelas VIP B memberikan hasil yang lebih rendah dengan selisih Rp205.177,15, dan untuk kelas I, II, dan III memberikan hasil yang lebih tinggi dengan selisih masing-masing sebesar Rp10.149,61 untuk kelas I, Rp77.324,28 untuk kelas II, dan Rp113.123,33 untuk kelas III. Perbedaan tersebut dapat dilihat dari penggunaan cost driver.
EVALUASI PENERIMAAN RETRIBUSI PASAR LAINO KABUPATEN MUNA
Authors: Akib Mulyati , Mirosea Nitri , Sarlina3 Sarlina
Published: February 2022

Penelitian ini bertujuan untuk mengevaluasi penerimaan retribusi Pasar Laino Kabupaten Muna tahun 2015-2019. Jenis data yang digunakan dalam penelitian ini yaitu data kuantitatif dan data kualitatitif, sumber data yang digunakan adalah data sekunder dan data primer. Metode pengumpulan data dalam penelitian ini adalah metode wawanc ara dan dokumentasi dengan menggunakan analisis deskriptif. Hasil penelitian menunjukkan bahwa penerimaan retribusi pasar laino secara keseluruhan mengalami fluktuasi. Peningkatan penerimaan hanya terjadi pada tahun 2017 sebesar Rp 350.168.500, selain itu realisasi penerimaan retribusi mengalami penurunan. Pada tahun 2015 realisasi penerimaan retribusi sebesar Rp 308.782.750, tahun 2016 realisasi penerimaan retribusi sebesar Rp 302.038.900. Sedangkan realisasi penerimaan retribusi tahun 2018 mengalami penurunan yang cukup besar dari Rp 350.168.500 menjadi Rp 283.875.000, pada tahun 2019 realisasi penerimaan retribusi sebesar Rp 281.036.750. Faktor yang mempengaruhi yaitu kurangnya kesadaran dari pedagang, serta kurangnya sarana dan prasarana. Dari data terebut disimpulkan bahwa penerimaan retribusi pasar belum optimal, realisasi penerimaan retribusi tidak mencapai target yang ditetapkan oleh Pemerintah Daerah.
ANALISIS ANALISIS KONTRIBUSI PAJAK KENDARAAN BERMOTOR DAN BEA BALIK NAMA KENDARAAN BERMOTOR DALAM MENINGKATKAN PENDAPATAN ASLI DAERAH DI PROVINSI SULAWESI TENGGARA
Authors: Awaluddin Ishak , Tamburaka Sulvariany , Ibrahim Muh.
Published: February 2022

Penelitian ini bertujuan untuk mengetahui dan menganalisis kontribusi pajak kendaraan bermotor dan bea balik nama kendaraan bermotor dalam meningkatkan pendapatan asli daerah di Provinsi Sulawesi Tenggara. Data yang digunakan adalah data primer dan sekunder dengan metode pengumpulan data dalam penelitian ini yaitu wawancara dan dokumentasi. Analisis data yang digunakan analisis deskriptif. Hasil penelitian ini menunjukan bahwa (1) penerimaan realisasi pajak kendaraan bermotor di Provinsi Sulawesi Tenggara tahun 2016-2019 memberikan kontribusi dengan rata-rata yaitu 14,95% termasuk dalam kriteria kurang, hal ini disebabkan karena kurangnya kesadaran wajib pajak terhadap pembayaran pajak kendaraan, terjadinya penurunan di jenis-jenis kendaraan dan kurang optimalnya pelayanan yang diberikan oleh setiap UPTB SAMSAT wilayah yang ada di Provinsi Sulawesi Tenggara (2) realisai untuk bea balik nama kendaraan bermotor tahun 2016-2019 yaitu berkontribusi dengan rata-rata 26,16% termasuk dalam kriteria sedang.
PENGARUH IMPLEMENTASI CORPORATE SOCIAL RESPONSIBILITY TERHADAP KESEJAHTERAAN MASYARAKAT (Studi Kasus Pada PT. Wijaya Karya Bitumen, Pasarwajo)
Authors: Husin Husin , Maya Sari Ika , Rafiudin Irmawani
Published: February 2022

Penelitian ini bertujuan untuk mengetahui dan menganalisis pengaruhimplementasi Corporate Social Responsibility terhadap kesejahteraan masyarakat. PT.Wijaya Karya Bitumen bergerak di sektor pertambangan pengolahan aspal. Populasidalam penelitian ini adalah sebanyak 177 orang. Sampel dalam penelitian inimenggunakan metode slovin, sehingga diperoleh sampel sebanyak 64. Metode analisisdata yang digunakan dalam penelitian ini adalah metode analisis deskriptif dan analisisregresi sederhana menggunakan aplikasi SPSS versi 22. Hasil penelitian inimenunjukkan bahwa variabel implementasi Corporate Social Responsbility berpengaruhsignifikan terhadap kesejahteraan masyarakat. Hal ini dilihat dari tingkat singnifikansisebesar 0,000 <  = 0,05. Artinya dengan adanya implementasi Corporate SocialResponsibility yang dilaksanakan PT. Wijaya Karya Bitumen maka sangat berdampakterhadap kesejahteraan masyarakat.
ANALISIS PENENTUAN HARGA JUAL KAIN TENUN MUNA BERDASARKAN METODE COST PLUS PRICING PADA UD. ANISA TENUN (KAB. MUNA)
Authors: Mirosea Nitri , Fitriaman Fitriaman , Soekirman Yesy
Published: February 2022

Penelitian ini bertujuan untuk mengetahui penentuan harga jual kain tenun Munapada UD. Anisa Tenun jika menggunakan metode cost plus pricing dengan pendekatanfull costing. Metode penelitian yang digunakan dalam penelitian ini adalah metodeanalisis deskriptif dengan pendekatan kuantitatif. Sumber data yang digunakan adalahdata primer dengan melakukan wawancara dan dokumentasi. Alat analisis yangdigunakan dalam penelitian ini adalah full costing method untuk perhitungan hargapokok produksi dan cost plus pricing method untuk penentuan harga jual. Hasilpenelitian ini menunjukkan bahwa dalam menentukan harga jual kain tenun Muna UD.Anisa Tenun masih menggunakan metode konvensional. Harga jual berdasarkan metodekonvensional lebih rendah dibandingkan harga jual berdasarkan metode cost pluspricing dengan pendekatan full costing. Dimana harga jual berdasarkan metodekonvensional dengan metode cost plus pricing memiliki under cost atau selisih hargasebesar Rp 10.457 hingga Rp 214.896 untuk kain tenun jenis bhotu dan leko.
Advances in Mesenchymal Stem Cell-Derived Exosomes as Drug Delivery Vehicles
Authors: Rao Dingyu , Huang Defa , Sang Chengpeng , Zhong Tianyu , Zhang Zuxiong , Tang Zhixian
Published: February 2022

Exosomes are tiny vesicles with a double membrane structure that cells produce. They range in diameter from 40 to 150 nm and may contain a variety of biomolecules including proteins and nucleic acids. Exosomes have low toxicity, low immunogenicity, and the ability to encapsulate a wide variety of substances, making them attractive drug delivery vehicles. MSCs secrete large amounts of exosomes and hence serve as an excellent source of exosomes. MSCs-derived exosomes have regenerative and tissue repair functions comparable to MSCs and can circumvent the risks of immune rejection and infection associated with MSC transplantation, indicating that they may be a viable alternative to MSCs’ biological functions. In this review, we summarized the drug delivery methods and advantages of exosomes, as well as the advancement of MSC exosomes as drug carriers. The challenges and prospects of using exosomes as drug delivery vectors are presented.
Mg-HA-C/C Composites Promote Osteogenic Differentiation and Repair Bone Defects Through Inhibiting miR-16
Authors: Qi Hong , Liu Yang , Wu Lu , Liu Chun , Ni Su , Liu Qizhan , Ni Xinye , Sun Qiang
Published: February 2022

The hydroxyapatite (HA) coating on carbon/carbon (C/C) is reasonable and feasible to obtain bone graft materials with appropriate mechanical and biological properties. However, improvement of the physical and chemical properties of HA-C/C composites to promote bone regeneration and healing remains a challenge. In our present study, the HA coatings on C/C with magnesium (Mg) (Mg-HA-C/C) composites were synthesized that Ca (NO3)2, Mg (NO3)2, and NH4H2PO4 were mixed and coatings were made by electromagnetic induction deposition’s heating. As determined with in vitro experiments, Mg-HA-C/C composites containing 10 and 20% Mg decreased miR-16 levels, increased cell viability, elevated the levels of osteogenesis-related genes, and promoted osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) seeded on their surfaces. In a rat model of skull defects, compared to the control group, at 4 and 12 weeks after the operation, the bone volume fraction (BV/TV) of Mg-HA-C/C composite group was increased by 8.439 ± 2.681% and 23.837 ± 7.845%, as well as the trabecular thickness (Tb.Th) was 56.247 ± 24.238 μm and 114.911 ± 34.015 μm more. These composites also increased the levels of ALP and RUNX2 in skull. The Mg-HA-C/C composite-enhanced bone regeneration and healing were blocked by in situ injection of an miR-16 mimic lentivirus vector. Thus, Mg-HA-C/C composites promote osteogenic differentiation and repair bone defects through inhibiting miR-16.
Single Cell RNA Sequencing Reveals Critical Functions of Mkx in Periodontal Ligament Homeostasis
Authors: Takada Kaho , Chiba Tomoki , Miyazaki Takayuki , Yagasaki Lisa , Nakamichi Ryo , Iwata Takanori , Moriyama Keiji , Harada Hiroyuki , Asahara Hiroshi
Published: February 2022

The periodontal ligament (PDL) comprises a fibrous tissue that connects teeth to alveolar bone and is essential for periodontal function. The transcription factor mohawk homeobox (Mkx) is expressed in the PDL where it plays an important role in the development and maintenance of the PDL. However, the precise and critical functions of Mkx in the cell populations comprising PDL have not yet been elucidated. The present study aimed to clarify the effects of a Mkx deficiency on PDL cellular heterogeneity and differences between gene expression in PDL tissues from wild-type (WT) (Mkx+/+) and Mkx knockout (Mkx−/−) rats using single-cell RNA sequencing. We identified 12 cell clusters comprising mesenchymal cells and macrophages. The expression of Mkx and scleraxis (Scx; another key transcription factor of PDL), was mutually exclusive, and partitioned mesenchymal cell clusters into Mkx and Scx types that dominantly expressed proteoglycans and elastic fibers, and type 1 and 3 collagen, respectively. Ossification-related genes were upregulated in mesenchymal cell and osteoblast clusters with more Mkx−/− than Mkx+/+ PDLs. Increased number of cells and inflammatory mediators were observed in macrophage clusters of Mkx−/− PDL. These results suggested that Mkx plays an important role in maintaining PDL homeostasis by regulating specific cell populations and gene expression.
Infections With Enterohepatic Non-H. pylori Helicobacter Species in X-Linked Agammaglobulinemia: Clinical Cases and Review of the Literature
Authors: Romo-Gonzalez Carolina , Bustamante-Ogando Juan Carlos , Yamazaki-Nakashimada Marco Antonio , Aviles-Jimenez Francisco , Otero-Mendoza Francisco , Espinosa-Rosales Francisco Javier , Espinosa-Padilla Sara Elva , Scheffler Mendoza Selma Cecilia , Durán-McKinster Carola , García-Romero Maria Teresa , Saez-de-Ocariz Marimar , Lopez-Herrera Gabriela
Published: February 2022

The genusHelicobacteris classified into two main groups according to its habitat: gastric and enterohepatic. Patients with X-linked agammaglobulinemia (XLA) appear to be associated with invasive infection with enterohepatic non-Helicobacter pylori species (NHPH), mainlyH. cinaediandH. bilis. Such infections are difficult to control and have a high potential for recurrence. The spectrum of illnesses caused by these species includes recurrent fever, bacteremia, arthritis, osteomyelitis, cellulitis, abdominal abscesses, and pyoderma gangrenosum-like ulcer. The presence of theseHelicobactersis particularly difficult to diagnose and eradicate, as they are very fastidious bacteria and present resistance to several types of antibiotics. We report two clinical cases of XLA patients infected with H.bilis.These infections were chronic in these patients and could not be eradicated in one of them. We also review the cases of enterohepatic non-Helicobacter pylorispecies (NHPH) in patients with this inborn error of immunity.
Raman Spectroscopy: A Potential Diagnostic Tool for Oral Diseases
Authors: Zhang Yuwei , Ren Liang , Wang Qi , Wen Zhining , Liu Chengcheng , Ding Yi
Published: February 2022

Oral diseases impose a major health burden worldwide and have a profound effect on general health. Dental caries, periodontal diseases, and oral cancers are the most common oral health conditions. Their occurrence and development are related to oral microbes, and effective measures for their prevention and the promotion of oral health are urgently needed. Raman spectroscopy detects molecular vibration information by collecting inelastic scattering light, allowing a “fingerprint” of a sample to be acquired. It provides the advantages of rapid, sensitive, accurate, and minimally invasive detection as well as minimal interference from water in the “fingerprint region.” Owing to these characteristics, Raman spectroscopy has been used in medical detection in various fields to assist diagnosis and evaluate prognosis, such as detecting and differentiating between bacteria or between neoplastic and normal brain tissues. Many oral diseases are related to oral microbial dysbiosis, and their lesions differ from normal tissues in essential components. The colonization of keystone pathogens, such as Porphyromonas gingivalis, resulting in microbial dysbiosis in subgingival plaque, is the main cause of periodontitis. Moreover, the components in gingival crevicular fluid, such as infiltrating inflammatory cells and tissue degradation products, are markedly different between individuals with and without periodontitis. Regarding dental caries, the compositions of decayed teeth are transformed, accompanied by an increase in acid-producing bacteria. In oral cancers, the compositions and structures of lesions and normal tissues are different. Thus, the changes in bacteria and the components of saliva and tissue can be used in examinations as special markers for these oral diseases, and Raman spectroscopy has been acknowledged as a promising measure for detecting these markers. This review summarizes and discusses key research and remaining problems in this area. Based on this, suggestions for further study are proposed.
Discursive Power: Trade Over Health in CARICOM Food Labelling Policy
Authors: Hinton Lucy
Published: February 2022

Moving towards a more sustainable, healthier, and equitable food future requires a significant system transformation. Policies to achieve this transformation are notoriously difficult to achieve, especially where actors with conflicts of interest are involved in governance. In this paper, I analyze how corporate actors frame issues inside a process to develop Front-of-Pack Labelling across the Caribbean. Focusing on three major framing strategies, I show how industry actors argued 1) (falsely) that FOPL would privilege Chilean food suppliers; 2) that FOPL would constitute a major transgression of international trade law; and 3) that a regional public health organization (the Pan-American Health Organization) is an illegitimate influence on the policy. Together, these three framing strategies reconstruct the policy problem as one of trade rather than public health. I argue that the resulting narrative is both a product and a function of the discursive power food companies wield in the standard-setting process and provide empirical detail about how food companies act to prevent policy attempts facilitating food systems transformation.
Smartwatch Electrocardiograms for Automated and Manual Diagnosis of Atrial Fibrillation: A Comparative Analysis of Three Models
Authors: Abu-Alrub Saer , Strik Marc , Ramirez F. Daniel , Moussaoui Nadir , Racine Hugo Pierre , Marchand Hugo , Buliard Samuel , Haïssaguerre Michel , Ploux Sylvain , Bordachar Pierre
Published: February 2022

Aims

The diagnostic accuracy of proprietary smartwatch algorithms and the interpretability of smartwatch ECG tracings may differ between available models. We compared the diagnostic potential for detecting atrial fibrillation (AF) of three commercially available smartwatches.

Methods

We performed a prospective, non-randomized, and adjudicator-blinded clinical study of 100 patients in AF and 100 patients in sinus rhythm, patients with atrial flutter were excluded. All patients underwent 4 ECG recordings: a conventional 12-lead ECG, Apple Watch Series 5®, Samsung Galaxy Watch Active 3®, and Withings Move ECG® in random order. All smartwatch ECGs were analyzed using their respective automated proprietary software and by clinical experts who also graded the quality of the tracings.

Results

The accuracy of automated AF diagnoses by Apple and Samsung outperformed that of Withings, which was attributable to a higher proportion of inconclusive ECGs with the latter (sensitivity/specificity: 87%/86% and 88%/81% vs. 78%/80%, respectively, p < 0.05). Expert interpretation was more accurate for Withings and Apple than for Samsung (sensitivity/specificity: 96%/86% and 94%/84% vs. 86%/76%, p < 0.05), driven by the high proportion of uninterpretable tracings with the latter (2 and 4% vs. 15%, p < 0.05).

Conclusion

Diagnosing AF is possible using various smartwatch models. However, the diagnostic accuracy of their automated interpretations varies between models as does the quality of ECG tracings recorded for manual interpretation.
The Role of Carbon Dioxide in the Rat Acute Stroke Penumbra
Authors: Yeo Leonard L. , Arnberg Fabian , Chireh Arvin , Sharma Vijay , Tan Benjamin , Gontu Vamsi , Little Philip , Holmin Staffan
Published: February 2022

Purpose

The vasodilatory response to inhaled CO2 occurs in the acute stroke ischemic penumbra and may be a potential therapeutic modality.

Methods

Twenty-two Sprague-Dawley rats were subjected to 90-min occlusion of the M2 segment of the middle cerebral artery (M2CAO) by endovascular technique. The animals were administered different C02 concentrations and scanned serially with 9.4 T MRI. Infarct tissue was determined by diffusion-weighted imaging (DWI) and hypoperfused tissue was determined by arterial spin labeling (PWI).

Results

4 animals were administered room air (RA)+ 6% CO2 (group 1), 6 animals RA+12% CO2 (Group 2) and 4 animals only RA (group 3). In the rats with CO2 administered (groups 1 and 2), the DWI lesion to cerebral hypoperfusion volume ratio (SD) at pre-CO2 administration, was 0.145(0.168), which increased to 0.708(0.731) during CO2 administration and reduced to 0.533(0.527) post-CO2 administration. In 9 of 10 rats the hypoperfused volume decreased when CO2 was administered. When CO2 was stopped the hypoperfused volume became larger again. Administration of RA+12% CO2 (Group 2) decreased the volume of CBF hypoperfusion significantly compared to the control group (95%CI: 0.084 ± 0.0213, p = 0.004).

Conclusion

Inhaled CO2 appears to reduce the size of the hypoperfused tissue volume during acute stroke and may be a potential modality for treatment of acute ischemic stroke. These findings will nonetheless need to be validated in a larger cohort in other centers.
Identification of Favorable Zones of Gas Accumulation via Fault Distribution and Sedimentary Facies: Insights From Hangjinqi Area, Northern Ordos Basin
Authors: Anees Aqsa , Zhang Hucai , Ashraf Umar , Wang Ren , Liu Kai , Mangi Hassan Nasir , Jiang Ren , Zhang Xiaonan , Liu Qi , Tan Shucheng , Shi Wanzhong
Published: February 2022

The Hangjinqi area was explored for natural gas around 40 years ago, but the efficient consideration in this area was started around a decade ago for pure gas exploration. Many wells have been drilled, yet the Hangjinqi area remains an exploration area, and the potential zones are still unclear. The Lower Shihezi Formation is a proven reservoir in the northern Ordos Basin. This study focuses on the second and third members of the Lower Shihezi Formation to understand the controlling factors of faults and sedimentary facies distribution, aimed to identify the favorable zones of gas accumulation within the Hangjinqi area. The research is conducted on a regional level by incorporating the 3D seismic grid of about 2500 km2, 62 well logs, and several cores using seismic stratigraphy, geological modeling, seismic attribute analysis, and well logging for the delineation of gas accumulation zones. The integrated results of structural maps, thickness maps, sand-ratio maps, and root mean square map showed that the northwestern region was uplifted compared to the southern part. The natural gas accumulated in southern zones was migrated through Porjianghaizi fault toward the northern region. Well J45 from the north zone and J77 from the south zone were chosen to compare the favorable zones of pure gas accumulation, proving that J45 lies in the pure gas zone compared to J77. Based on the faults and sedimentary facies distribution research, we suggest that the favorable zones of gas accumulation lie toward the northern region within the Hangjinqi area.
Geochemical Characteristics of Helium in Natural Gas From the Daniudi Gas Field, Ordos Basin, Central China
Authors: Liu Quanyou , Wu Xiaoqi , Jia Huichong , Ni Chunhua , Zhu Jianhui , Miao Jiujun , Zhu Dongya , Meng Qingqiang , Peng Weilong , Xu Huiyuan
Published: February 2022

Helium-bearing gas is accumulated in the Lower Ordovician, Upper Carboniferous, and Lower Permian reservoirs of the Daniudi gas field in Ordos Basin, and the helium concentrations and isotopic compositions are investigated in order to reveal the abundance and origin of helium. Geochemical characteristics indicate that the natural gas from the Daniudi gas field has helium concentrations of 0.0271–0.1273%, with R/Ra ratios of 0.007–0.072. The 4He/20Ne ratios range from 848 to 17,000, which are substantially higher than the ratio of air or air saturated water. The proved helium reserves of the Daniudi gas field exceed 100 × 106 m3, suggesting an extra-large helium gas field. Helium in the field is of crustal origin and derived from the radioactive decay of U and Th in the rocks and minerals, with no significant contribution by atmospheric or mantle-derived helium. The natural gas in the Daniudi gas field displays the characteristics of typical crustal helium, which is consistent with the gases from cratonic basins (Ordos, Sichuan, and Tarim) in China, whereas the gases from rift basins (Songliao, Bohai Bay, and Subei) have experienced a significant addition of mantle-derived helium.
Synoptic and Climatic Conditions of an Extreme Snowstorm Event Over Northeast China and Its Climate Predictability
Authors: Wang Lushan , Fan Ke
Published: February 2022

A blizzard struck Northeast China in November 2020, and the maximum daily snowfall broke its record since 1961. The synoptic and climatic conditions and the predictability of this extreme snowstorm event are examined by using the daily National Centers for Environmental Prediction (NCEP) reanalysis and the second version of the NCEP Climate Forecast System (CFSv2). The results show that an anomalous anticyclone over Japan and an anomalous cyclone in South China supplied abundant moisture and the rapidly enhanced Siberian high triggered the snowstorm. Before the snowstorm, the positive North Pacific Oscillation (NPO) and North Atlantic Oscillation (NAO) were essential for the accumulated water vapor. In addition, we find that the monthly NPO index and NAO index in November 2020 are both extremely strong compared to 1979–2019, and their combination converges to create the extreme snowstorm-related atmospheric circulation. The positive NPO and NAO together induce an anomalous anticyclone in Japan, which provides southerly water vapor transport to Northeast China. The midlatitude North Pacific warm sea surface temperature (SST) contributes to the positive NPO, and the Atlantic SST anomalies impact the positive NAO. However, the La Niña condition in 2020 might not be a key factor influencing the snowstorm. Finally, the subseasonal–seasonal skillful prediction of the snowfall can be made up to 3 days in advance. The CFSv2 had limited skill in forecasting the snowfall, NAO and NPO in November 2020. Improved predictability of extreme snowfall events is still needed.
A Lightweight Verification Method Based on Metamorphic Relation for Nuclear Power Software
Authors: Li Meng , Yang Xiaohua , Yan Shiyu , Liu Jie , Liu Yusheng , Sun Jun
Published: February 2022

The verification of nuclear design software commonly uses direct comparison methods. Benchmark questions, classical programs, experimental data, manual solutions, etc., would be used as expected results to compare with program outputs to evaluate the reliability of software coding and the accuracy of the numerical solution. Because nuclear power software numerically simulates complex physical processes, it involves many partial differential equations. It is usually challenging to construct analytical or accurate solutions and is expensive to develop benchmark questions and experimental data. Hence, the quantity of verification examples is small. By using the direct comparison method, verification is complicated, high cost, and inadequate. Entering the validation process without adequate proof will adversely impact the effectiveness and efficiency of validation. Metamorphic testing is an indirect verification technology that cleverly combines the nature of the model with software verification. It evaluates the correctness of the code by examining whether the program satisfies the metamorphic relation. Without manual solutions or benchmark examples, it has broad application prospects in the field of nuclear power. A lightweight verification method based on metamorphic relation has been produced here. Metamorphic relations are identified from physical equations, numerical algorithms, and program specifications. Next, they are explicitly used to system, integration, and unit tests to improve test adequacy. Because no need to develop verification examples, this method can detect code errors as soon as possible at a low cost, improve test efficiency, avoid mistakes remaining in subsequent stages and reduce the overall cost of verification.
Influence of the Assembly Method on the Cell Current Distribution of Series–Parallel Battery Packs Based on Connector Resistance
Authors: Chang Long , Ma Chen , Luan Chunxiao , Sun Zhezhe , Wang Cunyu , Li Hongyu , Zhang Yulong , Liu Xiangqi
Published: February 2022

In order to meet the energy and power requirements of large-scale battery applications, lithium-ion batteries have to be connected in series and parallel to form various battery packs. However, unavoidable connector resistances cause the inconsistency of the cell current and state of charge (SoC) within packs. Meanwhile, different assembly methods and module collector positions (MCPs) may result in different connector resistance arrangements, thereby leading to different cell current distributions. Therefore, the correlation of connector resistance to battery pack performance is worth investigating. Based on the simplified equivalent circuit model (ECM), the mathematical models of cell current distribution within packs under different assembly methods are obtained in this paper. Then, we use COMSOL Multiphysics simulation to analyze the guidelines of series assembly for parallel modules and then study the influences of connector resistance and MCP on series–parallel battery packs. The results show that the assembly method with an equal distance between each cell and the assembly contact surface for series assembly can effectively reduce the inhomogeneous current. However, the cell current and SoC distribution within the series–parallel battery pack is completely independent of the Z-configuration and ladder configuration. In addition, for series–parallel battery packs, the non-edge parallel module part of the series–parallel battery pack can be replaced with a series cell module (SCM) structure. Finally, the influences of the value of the connector resistance and current rate on the cell current distribution are discussed.
Landsat Data Ecosystem Case Study: Actor Perceptions of the Use and Value of Landsat
Authors: Molder Edmund B. , Schenkein Sarah F. , McConnell Abby E. , Benedict Karl K. , Straub Crista L.
Published: February 2022

It is well-known that Earth observation (EO) data plays a critical role in scientific understanding about the global environment. There is also growing support for the use of EO data to provide context-specific insights, with significant implications for their use in decision support systems. Technological development over recent years, including cloud computing infrastructure, machine learning techniques, and rapid expansion of the velocity, volume, and variety of space-borne data sources, offer huge potential to provide solutions to the myriad environmental problems facing society and the planet. The USGS/NASA Landsat Program, the longest continuously gathered source of land surface data, has played a central role in our understanding of environmental change, particularly for its contribution of longitudinal products that offer greater context for present research and decision support activities. The challenge facing the Landsat and EO data community, however, now lies in moving beyond context-specific knowledge generation to translating such knowledge into tangible value for society. Drawing from an open data ecosystem framework and qualitative social science methods, we map the Landsat data ecosystem (LDE) and the relationships linking multiple actors responsible for processing, indexing, analyzing, synthesizing, and translating raw Landsat data into information that is useful, useable, and used by end users in particular social-environmental contexts. Both the role of Big Data and associated technologies are discussed as they relate to the ultimate use of Landsat-derived information products to guide decision-making, and key data ecosystem characteristics that shape the likelihood of these products’ use are highlighted.
Study of Variations in Mass Absorption Efficiency of Elemental Carbon Influenced by Different Measurement Techniques and Vehicle Emission
Authors: Chen Dong , An Zhaojin , Zhao Qiuyue , Xia Sijia , Li Li , Guan Miao
Published: February 2022

An inter-comparison study of mass absorption efficiency (MAE) of elemental carbon (EC) by different sampling modes and measurements was conducted at the School of the Environment (SE) and Station for Observing Regional Processes of the Earth System (SORPES) in Nanjing from November 2015 to October 2016. Compared with offline sampling, the underestimation in MAE of online sampling was mainly due to the decreased optical attenuation (ATN) from the losing EC, and the difference in MAEs of the two types of sampling was greatly influenced by secondary organic aerosol (SOA) formation. Based on five temperature protocols, which include four NIOSH-derived protocols and one IMPROVE-A protocol, dependence of MAE on the temperature protocol was investigated. The main reason for the change in MAE estimation was the difference in EC determination. The result showed that low peak inert mode temperature (Tpeak) produced a small amount of pyrolysis carbon, and this carbon fraction was typically classified as organic carbon (OC), resulting in overestimation of EC and thereby underestimation of MAE. In order to study the influence of vehicle emission of highway on MAE values of EC, the simultaneous observation at SE and SORPES was conducted. The mean MAE of SE was 8.5% lower than that of SORPES. EC concentration was estimated to decrease by 0.13 μg/m3 with an increment distance of 100 m. Good correlation was found between the differential ATN for the two sites and the proportion of secondary organic carbon (SOC) at SORPES (R2 = 0.71). These results indicated that high MAE at SORPES was expected to be relevant with the dry deposition of EC from vehicle emission and the lensing effect by SOA coating.