bluuebunny/crossref_metadata_2025 huggingface dataset:
Hematological alterations associated with antiretroviral therapy in patients with human immunodeficiency virus
Authors: Carla María Taimal Sárez , Reiban Espinoza Esteban Adrián , Flores Siranaula Giselle Marina , Chuquitarco Marín Paul Alexis
Published: January 2023

Introduction: hematological alterations are very frequent and of multifactorial origin, they have been related to an increased risk of pathology progression and morbimortality in patients infected by the human immunodeficiency virus. Although there is a wide variety of scientific studies on the prevalence and pathogenesis of these alterations in HIV-positive patients, there are few investigations in our environment that report on the positive or negative effect of the administration of antiretroviral drugs.Objective: to determine the main hematologic alterations associated with antiretroviral therapy in patients infected by the human immunodeficiency virus.Method: narrative bibliographic review. The following databases were used for the research: PubMed, Cochrane and Scopus. Results: the prevalence of at least one hematological alteration was 1,1-58,6 % among HIV-infected patients receiving ART. The most frequent cytopenia was anemia followed by leukopenia and thrombocytopenia. Among the most significant risk factors, patients older than 50 years, female sex, zidovudine-based antiretroviral regimen, low BMI and CD4 T-cell count, high viral load, advanced stage and opportunistic infections were identified.Conclusions: the toxicity of antiretroviral drugs and the clinical conditions of the HIV-positive patient result in altered hematopoiesis affecting all three cell lines, patients may present with anemia, leukopenia, thrombocytopenia and/or pancytopenia. Failure to monitor and identify these disorders has a serious impact on the natural history of the disease in the patient
Risk factors associated with the development of pulmonary thromboembolism in adult patients diagnosed with COVID-19
Authors: Guapisaca Gaona John Stalyn , Guartambel Cajamarca Esthefany Belén , Muñoz Palomeque Danilo Gustavo , Angamarca Coello Mónica Fernanda
Published: January 2023

Introduction: COVID-19 infection encompasses several clinical manifestations ranging from cough, fever, myalgia, dyspnea, fatigue and rhinorrhea to an asymptomatic infection in some of the cases, to this is added and gains importance as a complication of COVID-19 coagulation diseases among which we find pulmonary thromboembolism (PTE), in fact it has been possible to identify patients who have come to die from this cause associated with SARS-CoV-2 infection.Objective: to describe the risk factors associated with the development of pulmonary thromboembolism in adult patients diagnosed with COVID-19.Methods: narrative literature review including meta-analyses, systematic reviews, review articles and research articles published in PubMed and Web of Science between 2020-2022.Conclusions: it was determined that there are risk factors that favor the development of PTE associated with COVID-19, of which we mention some such as age, admission to intensive care units (ICU) and even the patient's sex, it should be emphasized that each of these is related to a greater or lesser extent so they should be considered and associated taking into account that distinction
Bacteriological profile of diabetic foot infections and their antibiotic treatment of choice
Authors: Chuquitarco Marín Paul Alexis , Chunchi Ayala Luis Mario , Gómez Guapizaca Kelly Paola , Taimal Sárez Carla María
Published: January 2023

Introduction: diabetes mellitus is a metabolic disease in constant increase and with alarming projections in terms of incidence; likewise, the complications associated with this pathology are very frequent, such as the development of ulcers at foot level and their infection, which represent the main reasons for hospitalization and lower limb amputations.Aim: to describe the bacteriological profile of diabetic foot infections and their antibiotic treatment of choice.Methods: the study was non-experimental systematic review type following PRISMA methodology, in databases such as Pubmed, ScienceDirect, Scopus, Lilacs and Dialnet, considering certain inclusion criteria as articles published between January 2017 - December 2022. Results: a total of 9 articles were identified that met the eligibility criteria, identifying five most frequent bacteria such as Staphylococcus spp, Pseudomonas aeruginosa, among others. On the other hand, antibiotic groups such as penicillins associated with beta-lactamase inhibitors, third generation cephalosporins, among others, are drugs with high antibiotic sensitivity for the most frequent agents of diabetic foot infections.  Conclusions: based on the review performed, it is possible to conclude that diabetic foot infections are generally polymicrobial, being the Gram-negative group bacteria the most predominant compared to the Gram-positive group; additionally, for the antibiotic treatment of diabetic foot infections, it should be considered to cover the most frequent infectious agents.
Update on keratoconus treatment guidelines
Authors: Pacheco Faican Ana , Cervantes Anaya Luis , Iñiguez Emilio
Published: January 2023

Keratoconus is an inflammatory condition, a corneal ectasia characterized by an increase in corneal curvature. It occurs during puberty and progresses until the third or fourth decade of life, this pathology has no gender significance since it affects men and women equally. The incidence is 1/2000 cases in the population. Clinically, this ectasia leads to myopia and irregular astigmatism. The etiology is still not well known. There are several types of therapeutic options currently available, therefore a thorough knowledge is needed, where the aim of each treatment is to stabilize the corneal surface, improve vision and prevent the progression of this pathology. The aim of this research work is to perform an exhaustive search regarding the update of the behaviors to be followed in the treatment of keratoconus. The methodology of this work is a bibliographic review, narrative, non-experimental study. The results in this research is to find new updates in the treatment of keratoconus both advantages and disadvantages of each one. The treatments depend on the progression of keratoconus and its classification, because if it is mild, protective measures such as glasses can be used, but if the keratoconus is more severe, more invasive treatments such as surgical methods are needed, it is relevant to know the progression for an adequate evolution of this pathology
Hyperuricemia as a predictor and screening tool for preeclampsia
Authors: Tenemaza Ortega Katherine Valentina , Cárdenas Heredia Freddy Rosendo , Sánchez Peralta Santiago Martín , Ordoñez Vázquez María José
Published: January 2023

Introduction: preeclampsia is a hypertensive condition that negatively affects the pregnant woman and fetus, producing complications such as morbidity and mortality. Uric acid plays a role in the development of preeclampsia, although there is still no solid evidence to support this theory. This parameter is an additional tool in the screening for preeclampsia, which allows health personnel to identify and treat this complication early.Objective: describe hyperuricemia as a predictor and screening tool for preeclampsia.Methods: a review was carried out in different databases such as PubMed, Scopus and LILACS. After searching and filtering the results obtained, 8 articles were selected and analyzed accordingly.Result: the elevation of serum uric acid concentration preceded by a hypertensive state in pregnant women, especially during the first trimester, especially in complicated pregnancies and with a high risk of developing preeclampsia. In addition, it has been suggested that the measurement of this and other biomarkers that contribute to oxidative stress may help in the control and early treatment of the disease.Conclusion: hyperuricemia can be useful as a predictor and screening tool for preeclampsia, allowing to determine the severity of the pathology and the appearance of complications
Skin Manifestations associated with COVID-19
Authors: Estrada Morocho Jessica Alexandra , Espinoza Cárdenas Rolando , Gómez Guapizaca Kelly Paola , Montenegro Ortiz Glenda Iris
Published: January 2023

Introduction: the recognition of skin manifestations in patients with COVID-19 is very useful since its identification could help to diagnose SARS-COV-2 infection early and contribute to delaying the transmission of the virus.Objective: determine the skin manifestations associated with Covid 19.Methods: a narrative bibliographical review was carried out; For the search for information, Scopus and PubMed databases were used with MESH/DECS descriptors using keywords, taking into account the last five years, in English and Spanish, and with inclusion and exclusion criteria for the articles to be analyzed.Results: in Spain, 58 patients admitted to hospital for suspected COVID-19 infection presented skin lesions such as generalized maculopapular rash (20,7 %), Livedo reticularis (6,9 %), Urticaria (6,9 %) and others non-specific eruptions in 22,4 %.Conclusion: the most frequent lesions are urticarial rash, erythematous/maculopapular/morbilliform confluent rash, papulovesicular rash, chilblain-like acral pattern, livedo reticularis/racemose pattern, vasculitic purpuric pattern, cataloging the most frequent skin lesions to maculopapular rash that affect the trunk. and acral regions, especially toes and plantar region
Outcomes from applying the inverted classroom to a first-year structures module
Authors: Haynes Jonathan , Currie Neil
Published: January 2023

The Institution of Structural Engineers has recently invested considerable effort in the thorny problem of how to improve understanding of structural behaviour among undergraduate students. This paper, based on a winning entry to the Institution’s Excellence in Structural Engineering Education Award 2015, provides an account of action research in the application of inverted classroom principles to teaching first-year undergraduate civil engineering students, which was undertaken as a response to disappointing academic performance of the 2012/13 cohort. The process was based around a virtual learning environment. The effect upon engagement was better than expected, and demonstrated that it is possible to engineer enhanced performance by increasing student interaction with a virtual learning environment in conjunction with a structured learning schedule.
How can we create an engineering industry while building nothing?
Authors: Norman James , Ibell Tim , Broadbent Oliver
Published: January 2023

James Norman, Tim Ibell and Oliver Broadbent examine the challenges engineers will face in persuading clients to repurpose existing buildings in place of building new ones.
RANCANGAN SISTEM INFORMASI MONITORING PERSEDIAAN BAHAN BAKU PRODUKSI
Authors: Winarno Heru , Harjanto Luluk , Fianti Sarah
Published: January 2023

Production of raw materials is one of the scopes of PT. Cahaya Harapan Satya has a direct impact on production performance. Delays in the fulfillment of product orders ordered by consumers can harm the company. Meanwhile, if the supply of raw materials is excessive, it can increase storage costs, damage, and loss of raw materials. The purpose of this study is to overcome existing problems, for that, it is necessary to make an inventory system application that is useful for monitoring the availability of web-based production raw materials to solve the problems that occur. The web-based production raw material inventory data processing system that has been created is expected to be applied properly so that it can minimize and even solve problems that previously often occurred
Double Pass Solar Air Heater: A Review
Authors: Singh Varun Pratap , Meena Chandan Swaroop , Kumar Ashwani
Published: January 2023

Improvement in heat transfer rate and effectiveness of a solar air heater is always a matter of concern in the scientific community. Different steps have been taken to improve it, including the application of artificial roughness, double glazing, colour coating, and multi-pass flow. In this article, a detailed assessment of the efficiency and effectiveness of a solar air heater has been conducted by applying various types of double-pass arrangements. The effects of various methods applied so far are deeply analysed and discussed to create a better understanding. Future opportunities, challenges, and concerns are also addressed, with a fruitful conclusion in the last. Keywords: Solar energy, solar air heater, double-pass, artificial roughness, thermal performance
Aplicación de estrategias metodológicas de Anatomía Humana en la Universidad ISA de República Dominicana. 2018
Authors: Mugarra Romero Carmen Gisela , Corniel Rosa Pavel Julio
Published: January 2023

Este trabajo se realizó como una experiencia de profesores de la Universidad de Camagüey y de la Universidad ISA en República Dominicana, Santiago de los Caballeros, en la Facultad de Ciencias Sociales y Administración, con el objetivo de aplicar estrategias metodológicas para el desarrollo de competencias en Anatomía humana para cinco grupos del 8vo cuatrimestre de la Licenciatura en Educación, Concentración Ciencias de la Naturaleza, de enero a abril del 2018. La investigación se caracterizó por seguir una metodología mixta, basada en dos encuestas, la inicial y la final, a una muestra de 91 alumnos, de una población de 162, la observación durante la aplicación de las prácticas a toda la población y el análisis estadístico de los resultados en las evaluaciones, se aplicaron 23 técnicas participativas y el análisis de 7 situaciones problemas, se logró el desarrollo de las 10 competencias de Anatomía y el perfeccionamiento de los resultados docentes de los estudiantes llegando a la conclusión que la aplicación de las estrategias fue relevante en el proceso de enseñanza aprendizaje.
Palabras clave: estrategia metodológica, técnicas participativas, Anatomía humana.
متطلبات تطبيق معايير الاعتماد المدرسي في مدارس التعليم العام من وجهة نظر مديري المدارس الثانوية ومشرفي الإدارة المدرسية بمكة المكرمة
Authors: المالكي عبدالرحمن بن دخيل
Published: January 2023

هدفت الدراسة إلى التعرف على متطلبات تطبيق معايير الاعتماد المدرسي في مدارس التعليم العام بمكة المكرمة. وتحديد مدى توافر متطلبات تطبيق معيار (القيادة التربوية الفعالة، الشراكة المجتمعية ، المباني المدرسية ،التخطيط للجودة والتحسين المستمر) في مدارس التعليم العام بمكة، وأيضاً التعرف على الفروق ذات الدلالة الاحصائية بين استجابات أفراد المجتمع تعزى للمتغيرات التالية: (المسمى الوظيفي، الخبرة، الدورات التدريبية في مجال الجودة)، واستخدمت الدراسة المنهج الوصفي المسحي. وتم بناء الاستبانة من أربعة محاور، وتكون مجتمع الدراسة من جميع مديري المدارس الثانوية ومشرفي الادارة المدرسية بمكة المكرمة. وتوصلت الدراسة إلى عدة نتائج أهمها: تتوافر متطلبات تطبيق بعض معايير الاعتماد المدرسي في مدارس التعليم العام من وجهه نظر مديري المدارس الثانوية ومشرفي الإدارة المدرسية بمكة المكرمة بدرجة متوسطة، أيضاً عدم وجود فروق ذات دلالة إحصائية عند مستوى الدلالة الإحصائية (0.05α≤) بين متوسطات استجابات مديري المدارس الثانوية ومشرفي الإدارة المدرسية تعزى لمتغيري (المسمى الوظيفي، والدورات التدريبية) على مجالات أداة الدراسة،أيضاً وجو د  فروق  ذات  دلالة إحصائية عند مستوى الدلالة الإحصائية (0.05α≤) بين متوسطات استجابات مديري المدارس الثانوية ومشرفي الإدارة المدرسية تعزى لمتغير (الخبرة) في مجال المباني المدرسية ولصالح ذوي الخبرة الطويلة، وعدم وجود فروق ذات دلالة إحصائية لمستويات الخبرة على المجالات الكلية. وأوصت الدراسة بمنح مدير المدرسة الصلاحيات الكافية لاتخاذ القرارات المهمة داخل المدرسة بما يضمن تحقيق أهدافها. وإشراك المجتمع المحلي في حل مشاكل الطلاب داخل المدرسة.
أثر استراتيجية التساؤل الذاتي (K.W.L) في اكتساب المفاهيم العلمية في مادة العلوم للصف السابع الأساسي وتنمية دافعيتهم نحو تعلم العلوم في العاصمة عمان
Authors: ديوان سميرة محمد جبران
Published: January 2023

هدفت الدراسة الحالية إلى الكشف عن أثر استراتيجية التساؤل الذاتي (K.W.L)  في اكتساب المفاهيم العلمية والدافعية نحو تعلم مادة العلوم لدى طلبة الصف السابع الأساسي في مادة العلوم للصف السابع الأساسي في مديرية التربية والتعليم في قصبة عمان، ولتحقيق هدف الدراسة تم استخدام المنهج شبه التجريبي، وتكونت عينة الدراسة من(81) طالباً وطالبة تم اختيارهم بطريقة قصدية من طلبة الصف السابع الأساسي تم عشوائيا تحديد إحداها كمجموعة ضابطة بلغ عددها (40) طالباً وطالبة، والاخرى تجريبية بلغت (41) طالباً وطالبة درست باستراتيجية التساؤل الذاتي (L.W.L)، حيث تم بناء المادة التعليمية وفق باستراتيجية التساؤل الذاتي، وتم استخدام اختبار لاكتساب المفاهيم ومقياس الدافعية نحو تعلم العلوم، تم التحقق من خصائصهما السيكومترية. توصلت الدراسة إلى وجود فروق ذات دلالة إحصائيةً عند مستوى دلالة (α≤0.05) بين متوسطات درجات أفراد المجموعتين التجريبية والضابطة في القياس البعدي على اختبار اكتساب المفاهيم ومقياس الدافعية نحو تعلم العلوم، حيث بلغت قيمة (ت) المحسوبة =(-5.738)، مما يشير الى وجود أثر لاستراتيجية التساؤل الذاتي (K.W.L) في اكتساب المفاهيم العلمية في مادة العلوم لدى طلبة الصف السابع الأساسي وتنمية دافعيتهم نحو تعلم العلوم.
تقنية البلوكتشين وتطبيقاتها الاقتصادية
Authors: آمال مرزوق
Published: January 2023

ملخص الدراسة:

نحن على أبواب الانتقال من الاقتصاد القائم على الصناعة إلى الاقتصاد التقني بمختلف أدواته التكنولوجية والتي تعتبر تقنية البلوك تشين المكون الأحدث فيها. وتشكل هذه التقنية حجر الأساس في العملات الرقمية المشفرة مثل البتكوين والريبل، ولكن تبين أن  للبلوك تشين استعمالات  أخرى ومنه يهدف هذا البحث إلى تسليط الضوء على ماهية هذه التقنية والتطبيقات الواعدة التي تتيحها في مختلف القطاعات خاصة الاقتصادية منها. وتوصل البحث إلى أن سلسلة الكتل تقنية رقمية ابتكرت لتحل مشكلة انعدام الثقة عند إجراء المعاملات بين طرفين بدون الحاجة لطرف ثالث وسيط بينهما، ومنه فهي تقنية جد فعالة لتبادل القيم عبر الانترنيت. وهناك العديد من المشاريع الحقيقية الفعلية التي تستخدم تقنية البلوك تشين مع نتائج ملموسة عدا عن العملات المشفرة، مثل الخدمات المالية وسجلات الملكية والخدمات الحكومية وغيرها. كما تشهد توجه كبير لمختلف القطاعات الاقتصادية إليها لأنها تمكن من أداء الأعمال بفعالية وشفافية وبتكلفة أقل.
مستقبل الاقتصاد العربي في ظل العولمة الاقتصادية
Authors: امحمدي محمد , الزيود عبد الله سليمان عقلة
Published: January 2023

هدفت الدراسة إلى توضيح ماهية العولمة الاقتصادية، وبيان الآثار المرافقة لظهور العولمة الاقتصادية على الاقتصاد الدولي والعربي بشكل خاص، ومدى خطورة الانفتاح الاقتصادي نتيجة ظهور العولمة على مستقبل التجارة الوطنية، من خلال بيان التفاوت في المفاهيم ما بين التجارة الدولية والعولمة الاقتصادية. ولقد خلصت الدراسة إلى مجموعة من النتائج والتوصيات من اهمها: أن الدولة تشكل العنصر الأساسي في مفهوم الاقتصاد الدولي، بينما تشكل الشركات الرأسمالية المتعددة القوميات العنصر الأساسي في مفهوم العولمة، مكا أن العولمة الاقتصادية لأبد لها من أدوات ومؤسسات تنفذ من خلالها أعمالها المختلفة، من ابرزها الشركات متعددة الجنسيات، وترى الدراسة بضرورة دخول الدول العربية هذه الظاهرة في شكل وحدوي ليضمن لها القوة والديمومة في ظل التحديات التي تفرضها، والعمل على خلق أنموذج قادر على فرض خصوصيته في نطاق العولمة.
المضامين المرورية في كُتب اللّغة العربيِّة للمرحلة الأساسية العليا في الأردن: دراسة تحليلية
Authors: البرديني محمد حجازي
Published: January 2023

هَدفت هذه الدِّراسة إلى الكشف عن المضامين المروية، و درجة تضمين في كُتب اللغة العربيِّة، وتكوّنت عينة الدِّراسة من مجتمع الدِّراسة نفسه، وهي كُتب اللغة العربيِّة  للمرحلة الأساسية العليا الصادرة عن وزارة التّربية والتَّعليم للعام الدّراسي 2017/2018. وتحقيقاً لأهداف الدِّراسة، طوّر الباحث أداة قياس وتحليل اشتملت على ثلاثة مجالات تضمَّنت ستة عشر مضموناً ، وقد تمّ عرض الأداة على لجنة من المحكِّمين المتخصّصين في المناهج؛ للتأكد من صدقها، ثمّ قام الباحث بعملية التحليل حيث تمّ تكليف احد المعلمين، ويحمل درجة الدكتوراة  في اللغة العربيِّة للقيام بعملية التَّحليل أيضاً، وقد تمّ استخراج معامل الثّبات باستخدام معادلة هولستي  ( Holesti ) للثّبات،  حيث بلغ معامل الثبات عبر الزمن(2.91 %)، وعبر الأشخاص ( 6.86 %)، وهذا المعامل مقبول لأغراض الدِّراسة، وقد تمّ استخدام التّكرارات والنسب المئويِّة، والرُّتب، وكشفت نتائج الدراسة عن تدنّي توافر المضامين المرورية في تلك الكُتب . وفي ضَوء نتائج الدّراسة أوصى الباحث بتضمين المضامين المرورية في كُتب اللغة العربيِّة للمرحلة الأساسية العليا في الأردن، بإدخال معلومات مفاهيم مرورية، أو ربط المحتوى بموضوعات وقضايا متعلقة المضامين المرورية ؛ ولأهميتهما في حياة الفرد والمجتمع.
Geoelectrical Investigation of Groundwater Potential at Proposed Staff Quarters of FCE Technical, Gusau, Zamfara State, Nigeria
Authors: Anas Hussaini , Defyan Alhasan Usman , Muhammad Mannir
Published: January 2023

Geoelectric investigation was carried out at proposed staff quarters of FCE, Technical Gusau, located along Gusau – Zaria highway, Zamfara State, Nigeria with the aim of delineating the groundwater potentials. The study area lies in the Basement Complex region of Northern Nigeria and it is situated on Latitude 12o819.64”N to 12o08’24.65’’N and longitude 06o43’28.65’’E to 06o43’37.25’’E with an area coverage of 500 m by 500 m. Vertical Electrical Sounding (VES) technique was employed using Schlumberger array pattern. A total of thirty-six (36) VES points were sounded on Six (6) grided profiles(A-F) separated by 100 m apart with inter VES spacing of 100 m, The VES results depict two distinct curve types namely; H-type and A-type. The results also reveal three distinct geoelectric layers: the top layer, weathered/fractured layer and fresh basement. The top layer has resistivity, depth and thickness range of 10.4 – 158.8 Ωm, 0.4 – 3.6 m and 0.4 – 3.6 m respectively. The second layer has ranges of: resistivity, 6.3 – 525.3 Ωm; depth, 1.4 – 20.8 m, and thickness, 1.0 – 20.4 m. The third layer has resistivity values range of 278.6 – 2726.5 Ωm, its depth and thickness are not defined (to infinity). Seven VES stations (A3, A4, B4, C3, E2, F2 and F5) were delineated for groundwater potential having weathered/fractured resistivity varying between 37.4 and 121.1 Ωm. Depths range were found from 7.9 – 20.8 m and thickness varying between 6.6 and 20.4 m. The results of the study implies that the area has a good groundwater potentials.
A.I.’s vısıon of future cıtıes
Authors:   Faculty of Architecture, Dokuz Eylül University, İzmir, Türkiye, Yıldırım Erdem
Published: January 2023

Not only has artificial intelligence become ingrained in our everyday lives, but it has also been put to beneficial use in a wide variety of scholarly fields. Over the course of the past few decades, artificial intelligence has developed into an essential component of the optimization strategies utilized in the urban planning and design field. With the diversification and development of algorithms, although artificial intelligence has not yet begun to visually shape our cities, it has begun to be utilized as a design and planning derivative from urban design to planning scale, particularly in the context of smart cities. On the other hand, thanks to advancements in areas of machine learning, neural networks, deep learning, natural language processing, and computer vision, artificial intelligence can now generate authentic images based on texts that are provided. In this study, the perspectives of future cities obtained by text-to-image generation algorithms are analyzed. The visuals obtained with the open-source Stable Diffusion artificial intelligence's predictions about the future are presented in conjunction with numerous AI related contemporary design terms; smart city, sustainability, eco-design, biomimicry, and topology optimization. At each stage of history, the image of the cities of the future first appeared in literature and art before becoming a reality. Synthesizing contemporary works of art and literature in the millions of images that make up artificial intelligence's libraries today can inspire designers to construct our future.
Vibration Analysis and Digital Image Correlation Techniques for a Suspension Bridge
Authors:   Chaoyang University of Technology, LIN Yung-Chiang ,   Chaoyang University of Technology, TSENG Ching-Hao ,   Chaoyang University of Technology, Chiang Chih-Hung ,   Chaoyang University of Technology, Hung Wei-Hsiang
Published: January 2023

Bridge inspection is critical to safe transportation, especially in highly urbanized areas. Frequent inspection invoked by the un-scheduled maintenance for bridges is often subjected to the availability of NDT service providers. Hence the objective of the current research is to provide an economical NDT technique for the maintenance crew.
Digital image correlation techniques can be cost-effective for the displacement measurement of highway bridges using merely one high-resolution camera. The vibration analysis based on the remote measurements of high-speed camera systems is not only challenging but also prohibitively expensive. An alternative approach using two consumer-grade digital cameras has been developed. The field test has been successfully carried out for a 50-meter-span suspension bridge. Satisfactory results have been obtained in both the vertical displacement caused by a moving load and the mode shapes of the first and second vibration modes.
Investigation and optimization of parameters in face milling of S50C steel under MQL system
Authors: Pham Van-Hung , Nguyen Thuy
Published: January 2023

This paper aims to investigate cutting and lubrication parameters on surface roughness, cutting force, and material removal rate in face milling of JIS S50C carbon steel under a peanut oil-assisted Minimum Quantity Lubricant system. The five 3-level cutting process parameters were considered variants, including cutting speed, feed rate, depth of cut, air pressure, and lubrication flow. The experimental design was based on Taguchi's orthogonal array L27. The Analysis of variance is used to analyze the effect of cutting parameters and lubrication conditions on the surface roughness and cutting force. In addition, both regression optimizer procedures based on regression models and the Multi-Criteria Decision Making method were successfully applied to find the optimum conditions of the cutting parameter. The results showed the advantage and disadvantages of each technique. The Multi-Objective Optimization by Ratio Analysis was used in finding the best alternative. However, these values may not be an optimum condition. Mathematically, a regression optimizer may better determine the optimal value.
CRONOSEMIÓTICA NARRATIVA EN VIDEOJUEGOS: UN ESTADO DE LA CUESTIÓN EN EL ESTUDIO DEL TIEMPO LUDO-NARRATIVO
Authors: Parra Bravo Cristian Felipe
Published: January 2023

Uno de los llamados nuevos medios de mayor interés en la academia son los videojuegos. Las investigaciones en torno a él han visto aparecer contribuciones desde las corrientes narratológica y la ludológica; no obstante, el enfoque ludo-narrativo es uno de los más interesantes y significativos del área. Este enfoque (que relaciona ambas corrientes) es poco aplicado en investigación, donde el análisis narrativo del juego aparece aislado en los criterios clásicos del cine. Este ensayo releva la mirada ludo-narrativa en videojuegos poniendo énfasis en el análisis del tiempo. Presenta un resumen de las aportaciones teóricas en torno a sus implicancias semióticas mediante un enfoque exploratorio-descriptivo aplicado a través de unidades de observación genérica. El resultado es un panorama de la teoría en torno al estudio de las manipulaciones temporales en videojuegos y una discusión sobre la pertinencia de una cronosemiótica que establece el valor ludo-narrativo de estas manipulaciones.
THE OTHERLESS OTHER: LAS PASIONES MISÓGINAS DE LA MANOSFERA ESPAÑOLA
Authors: Lacalle Charo
Published: January 2023

El objetivo de este artículo es identificar las actitudes y las pasiones que emergen en los discursos misóginos de los dos foros más populares de la Manosfera española: Forocoches y Burbuja.info. La hipótesis subyacente al análisis semiótico realizado postula la correlación entre, por un lado, las pasiones de los cuatro microsistemas patémicos que configuran el dispositivo actancial de los celos (Greimas y Fontanille, 1991) y, por otro lado, los discursos de odio contra las mujeres en las subculturas más relevantes de la Manosfera: MRA (Men Rights Activists), MGTOW (Men Going Their Own Way), PUA (Pick up Artists) e Incels (Involuntary Celibates). Los mensajes de ambos foros figurativizan la misoginia a través de la expresión de dos “estados del alma”, la indignación y el desprecio, cuya configuración axiológica nos permite determinar los rasgos distintivos y las interacciones que caracterizan el simulacro pasional de los sujetos misóginos.
A multicenter comparative study of endoscopic ultrasound-guided fine-needle biopsy using a Franseen needle versus conventional endoscopic ultrasound-guided fine-needle aspiration to evaluate microsatellite instability in patients with unresectable pancreatic cancer
Authors: Takagi Tadayuki , Sugimoto Mitsuru , Imamura Hidemichi , Takahata Yosuke , Nakajima Yuki , Suzuki Rei , Konno Naoki , Asama Hiroyuki , Sato Yuki , Irie Hiroki , Nakamura Jun , Takasumi Mika , Hashimoto Minami , Kato Tsunetaka , Kobashi Ryoichiro , Hashimoto Yuko , Shibukawa Goro , Marubashi Shigeru , Hikichi Takuto , Ohira Hiromasa
Published: January 2023

Background/Aims: Immune checkpoint blockade has recently been reported to be effective in treating microsatellite instability (MSI)-high tumors. Therefore, sufficient sampling of histological specimens is necessary in cases of unresectable pancreatic cancer (UR-PC). This multicenter study investigated the efficacy of endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) using a Franseen needle for MSI evaluation in patients with UR-PC.Methods: A total of 89 patients with UR-PC who underwent endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) or EUS-FNB using 22-G needles at three hospitals in Japan (2018–2021) were enrolled. Fifty-six of these patients (FNB 23 and FNA 33) were followed up or evaluated for MSI. Patient characteristics, UR-PC data, and procedural outcomes were compared between patients who underwent EUS-FNB and those who underwent EUS-FNA.Results: No significant difference in terms of sufficient tissue acquisition for histology was observed between patients who underwent EUS-FNB and those who underwent EUS-FNA. MSI evaluation was possible significantly more with tissue samples obtained using EUS-FNB than with tissue samples obtained using EUS-FNA (82.6% [19/23] vs. 45.5% [15/33], respectively; p<0.01). In the multivariate analysis, EUS-FNB was the only significant factor influencing the possibility of MSI evaluation.Conclusions: EUS-FNB using a Franseen needle is desirable for ensuring sufficient tissue acquisition for MSI evaluation.
Ocena przydatności disdrometru laserowego i radaru meteorologicznego do szacowania wielkości opadów deszczu = Assessment of the suitability of the laser disdrometer and meteorological radar for rainfall estimation
Authors: Barszcz Mariusz Paweł
Published: January 2023

Measurements of precipitation conducted at the WULS-SGGW meteorological station in Warsaw in 2012-2014 and 2019-2020 using a tipping-bucket rain gauge and the laser disdrometer (Parsivel) as well as data obtained from the meteorological radar allowed to collect data enabling the assessment of the usefulness of the disdrometer and radar for estimating rainfalls. The data for the entire study period were used for analysis the correlation relationship between the 24-hour rainfall depths estimated on the basis of the rain gauge and the disdrometer. From the data set for the years 2012-2014, 21 individual events were selected for further analysis, for which rainfall data estimated on the basis of radar in the form of a PAC hydrological product were also available. The rainfall data from the disdrometer and radar were used for analysis the correlation relationships between them and corresponding measurements from the rain gauge. The scope of the study also included a comparison of the values of rainfall totals estimated for 21 single events using the disdrometer and radar in relation to data measured with the rain gauge. The simple method of adjusting the depths of rainfall estimated on the basis of the disdrometer proposed in this paper, was able to reduce significantly the differences in the values of rainfall totals for single events between the data from the disdrometer and the rain gauge.
Global vs. Local: A Quantitative Study of Factors Influencing Italian Consumers’ Preference in the Purchase of Food Products
Authors:   Department of Economics, Society, Politics, University of Urbino Carlo Bo, Italy, Aiudi Alice , Curina Ilaria ,   Department of Communication Sciences, Humanities and International Studies. University of Urbino Carlo Bo, Italy
Published: January 2023

Purpose: The study intends to expand the current literature on Italian consumers’ brand preferences between local vs. global alternatives in the specific Italian food sector. Design/methodology/approach: This study draws on concepts largely investigated like cultural identity theory, consumer ethnocentrism, and product category involvement to examine the mechanisms that drive Italian consumers to prefer alternative local or global brands in the food sector. A non-hierarchical cluster analysis represents the core part of the quantitative research that involved 412 participants. Findings: By confirming the validity of existing studies, the present paper contributes to the food consumption literature by testing a conceptual model that integrates previous research concepts, thus deepening the analysis of the factors affecting Italian consumers’ food brand preferences. The cluster analysis allowed for dividing Italian consumers into two distinguished groups with characteristics coherent inside the same group. Research limitations/implications: This study emphasizes the key relevance of the investigated variables in the implementation of positioning and communication strategies aimed at meeting the needs of specific markets in which firms operate, and it highlights the importance of analyzing those variables together. The sample composed of Italian consumers did not allow the generalizability of the results. Furthermore, this study focuses on the narrow category of chocolate bar products. Therefore, this does not permit the results to be generalized to other food products. Originality/value: The novel research is based on signaling theory that contributes to the local and global branding domains from the Italian perspective. This work is also the first to analyze the food sector and the importance that Italians attribute to their food products and traditions through a cluster analysis approach.
Motivators for and Barriers to Sustainable Supply Chain Practices Implementation
Authors:   Department of International Marketing, Institute of International Business and Economics, The Poznań University of Economics and Business, Poland, Małys Łukasz
Published: January 2023

Purpose: It is nowadays believed that the effective implementation of the principles of sustainable development in companies requires cooperation in entire supply chains. Companies are guided by various motivators and face various barriers to the implementation of sustainable supply chain practices (SSCPs); however, so far, no attention has been given to examining the relationship between them. Thus, the aim of the paper is to examine such relationships. Design/methodology/approach: The paper presents the results of a survey conducted on a sample of 500 companies. The aim of the paper is achieved by examining Spearman’s correlation coefficient. Findings: In most cases, a positive correlation is observed between the motivators for and barriers to SSCPs implementation. Additionally, such dependence occurs more often for external motivators, compared to internal motivators. Research implications: The activities supporting the implementation of SSCPs should concentrate on strengthening internal motivators in companies (e.g., by propagating relevant knowledge) as well as overcoming internal barriers. The importance of external motivators seems to be reduced by the coexistence of barriers. Originality/value: This paper contributes to supply chain and sustainable development literature by identifying a positive correlation between motivators for and barriers to SSCPs implementation. Such a finding may be important to policymakers, as it suggest that concentrating merely on motivating companies to implement sustainability principles may not be sufficient if it is not accompanied by barrier-breaking mechanisms.
Health System Efficiency of OECD Countries with Data Envelopment Analysis
Authors:   Malazgirt Vocational School, Muş Alparslan University, Muş, Turkey, Ersoy Yusuf , Aktaş Adem ,   Malazgirt Vocational School, Muş Alparslan University, Muş, Turkey
Published: January 2023

Purpose: This study is aimed at measuring the efficiency of 37 OECD countries for 2020 using the Data Envelopment Analysis (DEA) method. Besides, it is aimed at ranking the efficient decision making units by using the super-efficiency DEA model. Design/methodology/approach: In the study, analyses were carried out with input-oriented Charnes, Cooper and Rhodes (CCR), input-oriented Banker, Charnes and Cooper (BCC) models and super-efficiency models of these models by using 4 inputs and 3 outputs. Findings: As a result of the analysis, 14 countries in the CCR model and 20 countries in the BCC model were efficient. According to the results of the super-efficiency models, the efficient countries were ranked. Research limitations/implications: The limitations of the study are the analyses are based on input-oriented DEA models and the research was conducted in OECD countries. Originality/value: Performance evaluation of health systems has gained importance in recent years. Many countries are making efforts to improve their health systems. Due to epidemics such as COVID-19, OECD countries, like many countries around the world, have increased the share of health expenditures in GDP. Because of this situation, the evaluation of the performance of OECD countries in the field of health has emerged as a very important research topic.
Pedagogía social y evaluación de los servicios sociales comunitarios: un caso de estudio
Authors: Cortés-González Pablo , Martín Solbes Víctor M. , Vila Merino Eduardo Salvador
Published: January 2023

Este texto presenta parte de los resultados de un proyecto de investigación realizado en los Servicios Sociales Comunitarios del Ayuntamiento de Torremolinos con el objeto de evaluar su funcionamiento, procesos, políticas, etc., para el diseño de un plan estratégico comunitario. La metodología se ha diseñado desde planteamientos evaluativos y participativos contando con entrevistas, grupos focales y de reflexión, encuestas a la ciudadanía, observaciones y revisión documental. Los resultados muestran, por un lado, la necesidad de unificar procesos y protocolos, así como mejorar la definición de los roles de los trabajadores del servicio y, por otro lado, entender la interdisciplinariedad como una fortaleza en las políticas públicas y de acción social. Concluimos que, para atender a estas cuestiones, se hace necesario recuperar una mirada desde la pedagogía social, integrando un carácter más humano y educativo a las propias políticas públicas.
Effects of an IgE receptor polymorphism acting on immunity, susceptibility to infection, and reproduction in a wild rodent
Authors: Wanelik Klara M , Begon Mike , Bradley Janette E , Friberg Ida M , Jackson Joseph A , Taylor Christopher H , Paterson Steve
Published: January 2023

The genotype of an individual is an important predictor of their immune function, and subsequently, their ability to control or avoid infection and ultimately contribute offspring to the next generation. However, the same genotype, subjected to different intrinsic and/or extrinsic environments, can also result in different phenotypic outcomes, which can be missed in controlled laboratory studies. Natural wildlife populations, which capture both genotypic and environmental variability, provide an opportunity to more fully understand the phenotypic expression of genetic variation. We identified a synonymous polymorphism in the high-affinity Immunoglobulin E (IgE) receptor (GC and non-GC haplotypes) that has sex-dependent effects on immune gene expression, susceptibility to infection, and reproductive success of individuals in a natural population of field voles (Microtus agrestis). We found that the effect of the GC haplotype on the expression of immune genes differed between sexes. Regardless of sex, both pro-inflammatory and anti-inflammatory genes were more highly relatively expressed in individuals with the GC haplotype than individuals without the haplotype. However, males with the GC haplotype showed a stronger signal for pro-inflammatory genes, while females showed a stronger signal for anti-inflammatory genes. Furthermore, we found an effect of the GC haplotype on the probability of infection with a common microparasite, Babesia microti, in females – with females carrying the GC haplotype being more likely to be infected. Finally, we found an effect of the GC haplotype on reproductive success in males – with males carrying the GC haplotype having a lower reproductive success. This is a rare example of a polymorphism whose consequences we are able to follow across immunity, infection, and reproduction for both males and females in a natural population.
A nanobody toolbox to investigate localisation and dynamics of Drosophila titins and other key sarcomeric proteins
Authors: Loreau Vincent , Rees Renate , Chan Eunice HoYee , Taxer Waltraud , Gregor Kathrin , Mußil Bianka , Pitaval Christophe , Luis Nuno Miguel , Mangeol Pierre , Schnorrer Frank , Görlich Dirk
Published: January 2023

Measuring the positions and dynamics of proteins in intact tissues or whole animals is key to understanding protein function. However, to date, this is challenging, as the accessibility of large antibodies to dense tissues is often limited, and fluorescent proteins inserted close to a domain of interest may affect protein function. These complications apply in particular to muscle sarcomeres, arguably one of the most protein-dense assemblies in nature, which complicates studying sarcomere morphogenesis at molecular resolution. Here, we introduce a toolbox of nanobodies recognising various domains of the two Drosophila titin homologs, Sallimus and Projectin, as well as the key sarcomeric proteins Obscurin, α-Actinin, and Zasp52. We verified the superior labelling qualities of our nanobodies in muscle tissue as compared to antibodies. By applying our toolbox to larval muscles, we found a gigantic Sallimus isoform stretching more than 2 µm to bridge the sarcomeric I-band, while Projectin covers almost the entire myosin filaments in a polar orientation. Transgenic expression of tagged nanobodies confirmed their high affinity-binding without affecting target protein function. Finally, adding a degradation signal to anti-Sallimus nanobodies suggested that it is difficult to fully degrade Sallimus in mature sarcomeres; however, expression of these nanobodies caused developmental lethality. These results may inspire the generation of similar toolboxes for other large protein complexes in Drosophila or mammals.
Individual behavioral trajectories shape whole-brain connectivity in mice
Authors: Bogado Lopes Jadna , Senko Anna N , Bahnsen Klaas , Geisler Daniel , Kim Eugene , Bernanos Michel , Cash Diana , Ehrlich Stefan , Vernon Anthony C , Kempermann Gerd
Published: January 2023

It is widely assumed that our actions shape our brains and that the resulting connections determine who we are. To test this idea in a reductionist setting, in which genes and environment are controlled, we investigated differences in neuroanatomy and structural covariance by ex vivo structural magnetic resonance imaging in mice whose behavioral activity was continuously tracked for 3 months in a large, enriched environment. We confirmed that environmental enrichment increases mouse hippocampal volumes. Stratifying the enriched group according to individual longitudinal behavioral trajectories, however, revealed striking differences in mouse brain structural covariance in continuously highly active mice compared to those whose trajectories showed signs of habituating activity. Network-based statistics identified distinct subnetworks of murine structural covariance underlying these differences in behavioral activity. Together, these results reveal that differentiated behavioral trajectories of mice in an enriched environment are associated with differences in brain connectivity.
Maternal obesity blunts antimicrobial responses in fetal monocytes
Authors: Sureshchandra Suhas , Doratt Brianna M , Mendza Norma , Varlamov Oleg , Rincon Monica , Marshall Nicole E , Messaoudi Ilhem
Published: January 2023

Maternal pre-pregnancy (pregravid) obesity is associated with adverse outcomes for both mother and offspring. Amongst the complications for the offspring is increased susceptibility and severity of neonatal infections necessitating admission to the intensive care unit, notably bacterial sepsis and enterocolitis. Previous studies have reported aberrant responses to LPS and polyclonal stimulation by umbilical cord blood monocytes that were mediated by alterations in the epigenome. In this study, we show that pregravid obesity dysregulates umbilical cord blood monocyte responses to bacterial and viral pathogens. Specifically, interferon-stimulated gene expression and inflammatory responses to respiratory syncytial virus (RSV) and E. coli were significantly dampened, respectively . Although upstream signaling events were comparable, translocation of the key transcription factor NF-κB and chromatin accessibility at pro-inflammatory gene promoters following TLR stimulation was significantly attenuated. Using a rhesus macaque model of western style diet-induced obesity, we further demonstrate that this defect is detected in fetal peripheral monocytes and tissue-resident macrophages during gestation. Collectively, these data indicate that maternal obesity alters metabolic, signaling, and epigenetic profiles of fetal monocytes leading to a state of immune paralysis during late gestation and at birth.
Renal interstitial cells promote nephron regeneration by secreting prostaglandin E2
Authors: Liu Xiaoliang , Yu Ting , Tan Xiaoqin , Jin Daqing , Yang Wenmin , Zhang Jiangping , Dai Lu , He Zhongwei , Li Dongliang , Zhang Yunfeng , Liao Shuyi , Zhao Jinghong , Zhong Tao P , Liu Chi
Published: January 2023

In organ regeneration, progenitor and stem cells reside in their native microenvironment, which provides dynamic physical and chemical cues essential to their survival, proliferation, and differentiation. However, the types of cells that form the native microenvironment for renal progenitor cells (RPCs) have not been clarified. Here, single-cell sequencing of zebrafish kidney reveals fabp10a as a principal marker of renal interstitial cells (RICs), which can be specifically labeled by GFP under the control of fabp10a promoter in the fabp10a:GFP transgenic zebrafish. During nephron regeneration, the formation of nephrons is supported by RICs that form a network to wrap the RPC aggregates. RICs that are in close contact with RPC aggregates express cyclooxygenase 2 (Cox2) and secrete prostaglandin E2 (PGE2). Inhibiting PGE2 production prevents nephrogenesis by reducing the proliferation of RPCs. PGE2 cooperates with Wnt4a to promote nephron maturation by regulating β-catenin stability of RPC aggregates. Overall, these findings indicate that RICs provide a necessary microenvironment for rapid nephrogenesis during nephron regeneration.