bluuebunny/crossref_metadata_2025 huggingface dataset:
Psychosocial Intervention Model of Kerala, India During Pandemic COVID-19: “Ottakkalla Oppamundu (You’re not alone, we’re with you)”
Authors: Ravindran Rekha M. , Anjali Krishnan R. , Kiran P.S. , Mohan Bindhu , Shinu K.S.
Published: May 2021

Globally, the coronavirus disease 2019 (COVID-19) pandemic has resulted in several psychosocial manifestations across all socioeconomic strata. This study attempted to explore the details of a psychosocial support system implemented in Kerala, India, to address psychosocial issues during this pandemic. It employed a descriptive approach using qualitative and quantitative methods. The results can be summarized into 4 overarching themes: (1) process of implementation, (2) issues addressed, (3) experiences, and (4) success stories. This intervention targeted the whole population, with a specific focus on quarantined/isolated individuals and selected vulnerable groups. COVID pandemic has sowed several negative emotions, such as anxiety; and stigma and fearful thoughts, including suicidal ideations; trepidation regarding family members; and misinfodemics in general. Social and religious corollaries of the pandemic have intensified the psychological agony. The study provides an overview of the psychosocial intervention adopted by the state during the pandemic, which has helped both the beneficiaries and the providers. It has also helped to promote positive thinking and change the attitude toward the disease among the beneficiaries. It is highly commendable that timely intervention could obviate quite a few psychiatric emergencies, including suicides and aggressive behaviors. Considering its efficiency, flexibility, and sustainability, this model can be replicated in any setting.
Effectiveness and Policy Determinants of Sugar-Sweetened Beverage Taxes
Authors: Hagenaars L.L. , Jeurissen P.P.T. , Klazinga N.S. , Listl S. , Jevdjevic M.
Published: May 2021

Sugar consumption is on the rise globally with detrimental (oral) health effects. There is ample evidence that sugar-sweetened beverage (SSB) taxes can efficiently reduce sugar consumption. However, evidence alone is seldom enough to implement a policy. In this article, we present a narrative synthesis of evidence, based on real-world SSB tax evaluations, and we combine this with lessons from policy development case studies. This article is structured according to the Health Policy Analysis Triangle, which identifies a policy’s content and process and important contextual factors. SSB tax policy content needs to be coupled to existing problems and public sentiment, which depend on more aspects than aspects related to (oral) health alone. Whether or not to include artificially sweetened beverages, therefore, is not solely a matter of showing the evidence of their oral health impact but also dependent on the stated aim of a tax and public sentiment toward tax policies in general. SSB taxes also need to be in line with existing tax and decision-making rules. Earmarking revenue for specific (health promotion) purposes may therefore be less straightforward as it might appear. The policy process of creating context-sensitive SSB tax policy content is not easy either. Advocacy coalitions need to be formed early in the process, and stamina, expertise, and flexibility are required to get a SSB tax adopted in a specific community. This requires a meticulously considered SSB tax structure implementation process. Oral health professionals who want to lead the way in advocating for SSB taxes should realize that evidence-based arguments on potential effectiveness alone will not be enough to realize change. The oral health community can learn important lessons from other “doctor-activists” such as pulmonologists, who have successfully advocated for higher tobacco taxes by being visible in the public debate with clear messaging and robust policy proposals.
Recessive Mutations in ACP4 Cause Amelogenesis Imperfecta
Authors: Kim Y.J. , Lee Y. , Kasimoglu Y. , Seymen F. , Simmer J.P. , Hu J.C.-C. , Cho E.-S. , Kim J.-W.
Published: May 2021

Amelogenesis imperfecta (AI) is an innate disorder that affects the formation and mineralization of the tooth enamel. When diagnosed with AI, one’s teeth can be hypoplastic (thin enamel), hypomature (normal enamel thickness but discolored and softer than normal enamel), hypocalcified (normal enamel thickness but extremely weak), or mixed conditions of the above. Numerous studies have revealed the genes that are involved in causing AI. Recently, ACP4 (acid phosphatase 4) was newly found as a gene causing hypoplastic AI, and it was suggested that mutant forms of ACP4 might affect access to the catalytic core or the ability to form a homodimer. In this study, a Korean and a Turkish family with hypoplastic AI were recruited, and their exome sequences were analyzed. Biallelic mutations were revealed in ACP4: paternal (NM_033068: c.419C>T, p.(Pro140Leu)) and maternal (c.262C>A, p.(Arg88Ser)) mutations in family 1 and a paternal (c.713C>T, p.(Ser238Leu)) mutation and de novo (c.350A>G, p.(Gln117Arg)) mutation in the maternal allele in family 2. Mutations were analyzed by cloning, mutagenesis, immunofluorescence, immunoprecipitation, and acid phosphatase activity test. Comparison between the wild-type and mutant ACP4s showed a decreased amount of protein expression from the mutant forms, a decreased ability to form a homodimer, and a decreased acid phosphatase activity level. We believe that these findings will not only expand the mutational spectrum of ACP4 but also increase our understanding of the mechanism of ACP4 function during normal and pathologic amelogenesis.
Biomaterial and Biofilm Interactions with the Pulp-Dentin Complex-on-a-Chip
Authors: Rodrigues N.S. , França C.M. , Tahayeri A. , Ren Z. , Saboia V.P.A. , Smith A.J. , Ferracane J.L. , Koo H. , Bertassoni L.E.
Published: May 2021

Calcium silicate cements (CSCs) are the choice materials for vital pulp therapy because of their bioactive properties, promotion of pulp repair, and dentin bridge formation. Despite the significant progress made in understanding CSCs’ mechanisms of action, the key events that characterize the early interplay between CSC-dentin-pulp are still poorly understood. To address this gap, a microfluidic device, the “tooth-on-a-chip,” which was developed to emulate the biomaterial-dentin-pulp interface, was used to test 1) the effect of CSCs (ProRoot, Biodentine, and TheraCal) on the viability and proliferation of human dental pulp stem cells, 2) variations of pH, and 3) release within the pulp chamber of transforming growth factor–β (TGFβ) as a surrogate of the bioactive dentin matrix molecules. ProRoot significantly increased the extraction of TGFβ ( P < 0.05) within 24 to 72 h and, along with Biodentine, induced higher cell proliferation ( P > 0.05), while TheraCal decreased cell viability and provoked atypical changes in cell morphology. No correlation between TGFβ levels and pH was observed. Further, we established a biofilm of Streptococcus mutans on-chip to model the biomaterial-biofilm-dentin interface and conducted a live and dead assay to test the antimicrobial capability of ProRoot in real time. In conclusion, the device allows for direct characterization of the interaction of bioactive dental materials with the dentin-pulp complex on a model of restored tooth while enabling assessment of antibiofilm properties at the interface in real time that was previously unattainable.
Supporting rebels and hosting refugees: Explaining the variation in refugee flows in civil conflicts
Authors: Turkoglu Oguzhan
Published: May 2021

Why do some countries host more refugees than others? Previous research has focused on the role of geographical, political, and economic determinants, and little attention has been paid to civil conflict dynamics. In this article, I examine how a host country’s support for rebel groups may affect the number of refugees that it accommodates. Countries that support rebels host a higher number of refugees than others, as accommodating refugees can be the continuation of that support and help rebel groups in their armed struggle. By hosting people, countries may offer a sanctuary from which rebels can operate some of their insurgent activities. Rebel groups can exploit these camps for recruitment, training, and benefiting from the main services such as health care. In addition, when rebels operate in host countries, these countries may monitor, impact, or even direct the strategies of insurgent groups. Analysis of refugee flows between 1968 and 2011 suggests that countries which support rebel groups host twice as many refugees as others. Results are robust to various model specifications, two different sources for the main explanatory variable, matching analysis, and additional checks. Findings of this article highlight the importance of conflict dynamics in explaining the variation in refugee flows.
The Impact of Police Behavior During Death Notifications on Mental Health of the Bereaved: A Cross-Sectional Study
Authors: Hofmann Laura , Glaesmer Heide , Przyrembel Marisa , Wagner Birgit
Published: May 2021

The delivery of death notifications may affect the mental health of bereaved individuals. Police officers are often the first people with whom the bereaved have contact in this exceptional situation. Therefore, it is essential to assess the behavior of police officers and the impact on the bereaved. We examined the experiences of 86 individuals who received the notification through the police and assessed symptoms of prolonged grief, depression, and posttraumatic stress symptoms. The interaction with police was associated with posttraumatic avoidance behavior and the presence of another supporting person was associated with higher scores of depression. Handing out information material and staying with the bereaved was related to a positive evaluation of police behavior. It appears important to identify helpful and problematic behavior for a better understanding and for an adaptation of existing guidelines.
Revisiting the original reasons for excluding inorganic fertilizers in organic farming—Why the ban is not consistent with our current scientific understanding
Authors: Kirchmann Holger
Published: May 2021

This paper reviews the original reasons of the organic farming movement for excluding mineral (inorganic) fertilizers. In this paper, their theories and decision criteria for excluding use of inorganic fertilizers in crop production were revisited. Original reasons for banning inorganic fertilizers were subjected to scientific scrutiny, which was not possible when they were formulated 50–100 years ago due to limited knowledge of the soil-crop system. The original reasons were as follows: Rudolf Steiner, the founder of biodynamic farming, played down the physical role of plant nutrients and pointed out “flow of forces” as being most important for soils and crops. Eve Balfour and Albert Howard, founders of the Soil Association in England, claimed that inorganic fertilizer increases the breakdown of humus in soil, leading to a decline in soil fertility. Hans-Peter Rusch, the founder of biological organic farming, considered inorganic fertilizers to be imbalanced products not matching crop composition and not in synchrony with crop demand. When testing these historical statements as scientific hypotheses, older and modern scientific literature was used for validation. Steiner’s belief about the “flow of forces” has not be verified using current methodologies. The claim by Balfour and Howard that inorganic fertilizers accelerate soil organic matter decomposition is not substantiated by data from long-term field experiments on carbon and nitrogen cycling in soil-plant systems. The statement by Rusch that inorganic fertilizers supply crops inappropriately is difficult to uphold, as the composition, time, and rate of application and the placement of fertilizer in soil or on foliage can be fully adapted to crop requirements. In light of accumulated scientific evidence, the original arguments lack validity. The decision to ban inorganic fertilizers in organic farming is inconsistent with our current scientific understanding. Scientific stringency requires principles found to be erroneous to be abandoned.
The social space and misrecognition in 21st century France
Authors: Atkinson Will
Published: May 2021

This article seeks to revisit the French social space 30 years after Pierre Bourdieu first mapped it in Distinction. Using data from the International Social Survey Programme, it deploys geometric data analysis to construct a model of the space of class positions that is remarkably similar in its structure to that presented by Bourdieu despite three decades of economic transformation. The relationship with occupational groups and geographical space is also familiar, though gender and, to a greater extent, age are perhaps more prominent than when Bourdieu was writing. The article then goes on to demonstrate the multidimensional nature of symbolic violence, in the form of perception of one’s place, and the manner in which social reproduction is misrecognised. On the latter point, it transpires that while there is recognition of unfair advantage, not only is faith in meritocracy the prevailing view but the dominated are the most likely to deny that having educated parents makes a difference to whether one ‘gets ahead’ or not.
Does better job accessibility help people gain employment? The role of public transport in Great Britain
Authors: Bastiaanssen Jeroen , Johnson Daniel , Lucas Karen
Published: May 2021

The combined decentralisation of many firms and services and the increasing concentration of traditional public transport services in the main corridors of urban centres have made it more difficult for people to access jobs, in particular when residing outside these prime accessibility areas. This is the first national study within the context of Great Britain to examine whether better public transport job accessibility, modelled at the micro level of individuals, improves employment probabilities for people living in Great Britain. While previous studies have typically concentrated on US metropolitan areas, our study uses British national employment micro datasets to assess which urban and rural areas and population groups would benefit from better public transport services. In an important departure from most standard accessibility methodologies, we computed a public transport job accessibility measure applied nationwide and combined this with individual-level employment probability models for Great Britain. The models were corrected for endogeneity by applying an instrumental variable approach. The study finds that better public transport job accessibility improves individual employment probabilities, in particular in metropolitan areas and smaller cities and towns with lower car ownership rates and in low-income neighbourhoods. It further shows that mainly lower educated groups and young people would benefit from better public transport job accessibility. The findings in this study are important for policymakers in that they imply that, in particular, job seekers who rely on public transport services may benefit from more targeted public policies to improve their accessibility to employment and thereby their social mobility.
Of political entrepreneurs: Assembling community and social capital in Hyderabad’s informal settlements
Authors: Jonnalagadda Indivar
Published: May 2021

This paper theorises the political entrepreneurship of local political actors variously described as brokers, fixers or leaders, by examining their consistent and flexible labour towards gaining and maintaining political influence in informal settlements. Through close attention to how two exemplary individuals work and network with a combination of political parties, non-governmental organisations (NGOs) and local associations, I reveal the crucial role of political entrepreneurs in organising or representing local populations as legible ‘communities’, and thus, in mediating relations between communities and external agencies such as the state, political parties, non-governmental organisations (NGOs) and also academic researchers. Observing informal settlements in this relational framework sheds light on how political entrepreneurs compete to become obligatory intermediaries between various institutions. This approach destabilises conceptions about the social infrastructure and social capital of a locality which underlie many community development programmes. Further, I argue that in the long-term, the careers of political entrepreneurs are punctuated by structural constraints in the form of limits to political party patronage, volatile NGO funding and the transient presence of academic researchers. The work of reproducing the social capital of the neighbourhood becomes a persistent and anxious striving with few actual opportunities for mobility.
“Snet,” Our Man in Miami: Urban Tourism, Illegal Gambling, and the Challenge of a Sinful Southern City, 1941-1944
Authors: Revell Keith D.
Published: May 2021

South Florida developed as an urban gambling resort center that posed both cultural and political challenges to the traditional southern values that animated the state’s approach to regulating vice. This article examines the conflicts over vice tourism in South Florida by focusing on the relationship between Governor Spessard Holland and former Miami Beach Mayor Louis “Snet” Snedigar. Snedigar became Holland’s undercover informant when the governor cracked down on illegal gambling as part of his effort to fund the state’s old-age pension program by taxing bets placed at horse tracks in South Florida. By exploring the entanglement between a conservative southern state and a “liberal” urban outpost, this article illustrates how the southern approach to urban development forestalled the emergence of South Florida as a recreational gambling resort comparable to Las Vegas.
The effect of the airflow pattern inside air gaps on the assessment of interstitial mould: A theoretical approach
Authors: Efthymiopoulos Spyridon , Altamirano Hector , Aktas Yasemin Didem
Published: May 2021

Internal wall insulation is one of the few, possibly, the only feasible solution to efficiently reduce heat losses through the external walls of buildings where the application of external insulation is not an option, for example, in conservation areas. However, the application of this intervention may lead to unintended consequences, such as moisture accumulation and mould growth. Currently, no international standards and regulations exist to evaluate these hazards via non-destructive inspections. Air sampling through impaction and culture-based analysis was suggested in previous research as a potential non-disruptive methodology for interstitial mould testing. The method requires the perforation of the inner side of a wall and the creation of airflow through the operation of a pump, to allow the collection of particles from the confined space of interest. The present study aimed to assess the location of perforations and their effect on the airflow created and the airflow pattern variations due to changes in the airflow velocity at the outlet. Results regarding airflow features such as the turbulence intensity, dynamic pressure and volume-averaged velocity were also extracted and discussed.

Practical application: The rapid changes in climate and net-zero emissions targets call for major improvements of the existing building stock towards a more sustainable future. The installation of internal wall insulation is one of the few and might be the only feasible solution for the efficient reduction of heat losses through uninsulated walls. However, this intervention might lead to moisture accumulation and thus moisture-related problems such as mould growth. This study aims to build upon previous work on interstitial mould growth assessment and contribute to the development of a well-defined testing protocol for building professionals.
Is Gay Tourism More Than Tourism? A Case Study of Puerto Vallarta, MX
Authors: Bailey Emma G.
Published: May 2021

The reasons gay men seek out gay travel destinations has been well established in the literature. However, less research has been published on the consequences of that travel on the destinations themselves and the effect of gay tourism on the LGBTQ+ community as a whole. I use ethnographic research in Puerto Vallarta, Mexico, a popular international gay tourist destinations for American and Canadian gay men. I focus on how gay destinations are constructed as sites where members of the gay community can experience acceptance and inclusion and I ask the following questions, is this acceptance and inclusion dependent upon consumption? Are the tourist site and expectations for behavior in those sites oppressively normal? That is, does the site create a normative standard of behavior for gay tourists? Furthermore, while gay tourists may experience inclusion and a level of acceptance, how does gay tourism affect the destination site itself? Is this acceptance and inclusion problematized by larger systems of inequality such as class, gender, and race? Lastly, as members of a historically oppressed group, does and should gay tourism rise above its commodification to produce just, equitable relationships within and beyond the LGBTQ+ community including the environment?
Sodium Alginate Ultrasound Phantom for Medical Education
Authors: Aoyagi Minoru
Published: May 2021

The ultrasound phantoms used to educate medical students should not only closely mimic the ultrasound characteristics of human soft tissues but also be inexpensive and easy to manufacture. I have been studying handmade ultrasound phantoms and proposed an ultrasound phantom comprising calcium alginate hydrogel that met these requirements but caused a speckle pattern similar to that observed in ultrasound images of liver. In this study, I show that adding ethanol to the precursors used to fabricate the phantom reduces the speckle pattern. The ultrasound propagation velocity and attenuation coefficient of the phantom were 1561 ± 8 m/s and 0.54 ± 0.18 dB/cm/MHz, respectively (mean ± standard deviation), which are within the ranges of those in human soft tissues (1530-1600 m/s and 0.3-1.0 dB/cm/MHz, respectively). This phantom is easy to fabricate without special equipment, is inexpensive, and is suitable for elementary training on ultrasound diagnosis, operation of ultrasound-guided needles, and blind catheter insertion.
Intimate Partner Violence among Korean Immigrant Women in the United States: Intersectionality of Gender Norms, Immigration, and Socioeconomic Status
Authors: Lee Sei-Young , Choi Ga-Young
Published: May 2021

With the theory of feminist intersectionality, this study examined intimate partner violence (IPV) among Korean immigrant women focusing on gender norms, immigration, and socioeconomic status in the contexts of Korean culture. A total of 83 Korean immigrant women who were receiving a social service from non-profit agencies in ethnically diverse urban areas were recruited with a purposive sampling method. Hierarchical regressions were conducted to examine changes in variance explained by models. Having non-traditional gender norms, a college degree or higher education, immigrant life stresses, and living longer in the United States were positively associated with IPV while having higher income and being more fluent in English were negatively associated with IPV. Findings were discussed to understand Korean immigrant women’s internal conflict affected by their higher education and more egalitarian gender norms under the patriarchal cultural norms while experiencing immigrant life stresses and living in the United States. Implication for practice was also discussed.
Transcatheter aortic valve implantation in low-risk patients: A case of rational over exuberance. The time is not now
Authors: Navaratnarajah Manoraj , Luthra Suvitesh , Ohri Sunil
Published: May 2021

Background

Review of evidence and concerns, relating to extension of transcatheter aortic valve implantation usage to low–risk patients.

Methods

Comprehensive literature review was conducted identifying articles relating to transcatheter aortic valve implantation.

Results

Transcatheter aortic valve implantation is effective in patients with aortic stenosis. Currently, long-term durability and cost-effectiveness are unproven, anticoagulation requirement undefined, permanent pacemaker implantation and paravalvular leak rates higher than following surgical aortic valve replacement.

Conclusions

Current evidence supporting transcatheter aortic valve implantation usage in low-risk patients is insufficient. Extending use now, to this large young patient population is premature, and should be delayed.
Understanding and addressing challenges for advance care planning in the COVID-19 pandemic: An analysis of the UK CovPall survey data from specialist palliative care services
Authors: Bradshaw Andy , Dunleavy Lesley , Walshe Catherine , Preston Nancy , Cripps Rachel L , Hocaoglu Mevhibe , Bajwah Sabrina , Maddocks Matthew , Oluyase Adejoke O , Sleeman Katherine , Higginson Irene J , Fraser Lorna , Murtagh Fliss ,   On behalf of the CovPall study team
Published: May 2021

Background:

Specialist palliative care services play an important role in conducting advance care planning during COVID-19. Little is known about the challenges to advance care planning in this context, or the changes services made to adapt.

Aim:

Describe the challenges that UK specialist palliative care services experienced regarding advance care planning during COVID-19 and changes made to support timely conversations.

Design:

Online survey of UK palliative/hospice services’ response to COVID-19. Closed-ended responses are reported descriptively. Open-ended responses were analysed using a thematic Framework approach using the Social Ecological Model to understand challenges.

Respondents:

Two hundred and seventy-seven services.

Results:

More direct advance care planning was provided by 38% of services, and 59% provided more support to others. Some challenges to advance care planning pre-dated the pandemic, whilst others were specific to/exacerbated by COVID-19. Challenges are demonstrated through six themes: complex decision making in the face of a new infectious disease; maintaining a personalised approach; COVID-19-specific communication difficulties; workload and pressure; sharing information; and national context of fear and uncertainty. Two themes demonstrate changes made to support: adapting local processes and adapting local structures.

Conclusions:

Professionals and healthcare providers need to ensure advance care planning is individualised by tailoring it to the values, priorities, and ethnic/cultural/religious context of each person. Policymakers need to consider how high-quality advance care planning can be resourced as a part of standard healthcare ahead of future pandemic waves. In facilitating this, we provide questions to consider at each level of the Social Ecological Model.
Preliminary study of microparticle coagulation properties in septic patients with disseminated intravascular coagulation
Authors: Meng Shishuai , Kang Kai , Fei Dongsheng , Yang Songlin , Gu Quankuan , Pan ShangHa , Zhao Mingyan
Published: May 2021

Background

Sepsis typically results in enhanced coagulation system activation and microthrombus formation. Microparticle (MP) production promotes coagulation and enhances pro-coagulation. This study investigated how circulating MP levels and tissue factor-bearing MP (TF+-MP) activity caused coagulation in patients with septic disseminated intravascular coagulation (DIC).

Methods

Thirty patients with septic DIC and 30 healthy controls were studied from December 2017 to March 2019. Patient blood samples were collected at enrolment (day 1) and on days 3 and 5; DIC scores and Sequential Organ Failure Assessment (SOFA) scores were recorded. TF+-MP activity was measured using TF-dependent factor Xa generation experiments. Circulating MP concentrations were determined by MP capture assay. Clotting factor activity, antithrombin level, soluble thrombomodulin, and serum tissue factor pathway inhibitor (TFPI) concentrations were measured.

Results

Patients with septic DIC had lower circulating MP levels than healthy control patients. Circulating MP levels in patients with septic DIC were positively correlated with DIC scores and negatively correlated with coagulation factors, but TF+-MP activity did not correlate with clotting factor levels and TFPI.

Conclusions

In patients with septic DIC, circulating MP levels are important in promoting coagulation activation and increasing clotting factor consumption. TF+-MP activity may not be the main form of active TF.
Pathogenesis and characteristics of large ameloblastoma of the jaw: a report of two rare cases
Authors: Qiao Xue , Niu Xing , Liu Jiayi , Chen Lijie , Guo Yan , Zhong Ming
Published: May 2021

Ameloblastoma is a common odontogenic epithelial tumor that exhibits various biological behaviors, ranging from simple cystic expansion to aggressive solid masses characterized by local invasiveness, a high risk of recurrence, and even malignant transformation. We report on two cases of unusually large solid ameloblastomas. We detected epithelial–mesenchymal transition-related gene expression and HRAS gene single nucleotide polymorphisms, providing possible molecular evidence of mesenchymal morphological changes in ameloblastoma. The detailed analysis of the pathogenesis of these two cases of ameloblastoma may deepen our understanding of this rare disease and offer promising targets for future targeted therapy.
An 8-gene DNA methylation signature predicts the recurrence risk of cervical cancer
Authors: Ma Jing-Hang , Huang Yu , Liu Lu-Yao , Feng Zhen
Published: May 2021

Objective

This study examined the predictive utility of DNA methylation for cervical cancer recurrence.

Methods

DNA methylation and RNA expression data for patients with cervical cancer were downloaded from The Cancer Genome Atlas. Differentially methylated genes (DMGs) and differentially expressed genes were screened and extracted via correlation analysis. A support vector machine (SVM)-based recurrence prediction model was established using the selected DMGs. Cox regression analysis and receiver operating characteristic curve analysis were used for self-evaluation. The Gene Expression Omnibus (GEO) database was applied for external validation. Functional enrichment was determined using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses.

Results

An eight-gene DNA methylation signature identified patients with a high risk of recurrence (area under the curve = 0.833). The SVM score was an independent risk factor for recurrence (hazard ratio [HR] = 0.418; 95% confidence interval [CI] = 0.26–0.67). The independent GEO database analysis further supported the result.

Conclusion

An eight-gene DNA methylation signature predictive of cervical cancer recurrence was identified in this study, and this signature may help identify patients at high risk of recurrence and improve clinical treatment.
Repetition Suppression in Visual and Auditory Modalities Affects the Sound-Induced Flash Illusion
Authors: Wang Aijun , Zhou Heng , Yu Wei , Zhang Fan , Sang Hanbin , Tang Xiaoyu , Zhang Tianyang , Zhang Ming
Published: May 2021

Sound-induced flash illusion (SiFI) refers to the illusion that the number of visual flashes is equal to the number of auditory sounds when the visual flashes are accompanied by an unequal number of auditory sounds presented within 100 ms. The effect of repetition suppression (RS), an adaptive effect caused by stimulus repetition, upon the SiFI has not been investigated. Based on the classic SiFI paradigm, the present study investigated whether RS would affect the SiFI differently by adding preceding stimuli in visual and auditory modalities prior to the appearance of audiovisual stimuli. The results showed the auditory RS effect on the SiFI varied with the number of preceding auditory stimuli. The hit rate was higher with two preceding auditory stimuli than one preceding auditory stimulus in fission illusion, but it did not affect the size of the fusion illusion. However, the visual RS had no effect on the size of the fission and fusion illusions. The present study suggested that RS could affect the SiFI, indicating that the RS effect in different modalities would differentially affect the magnitude of the SiFI. In the process of multisensory integration, the visual and auditory modalities had asymmetrical RS effects.
The retirement puzzle
Authors: Ruthbah Ummul
Published: May 2021

The present-day retirees may not be as well off as they expect to be during their retirement. Given the current state of the world – higher life expectancy, close to zero real interest rate and the economic turmoil caused by Covid-19 pandemic, a superannuation balance as large as $545,000 may not be enough to support a comfortable lifestyle. Besides, the means-tested age pension results in cases where spending at retirement does not increase proportionally with assets, providing incentives for a broad spectrum of people to deplete their superannuation in the early years of retirement, with significant negative consequences for government finances.

JEL Classification: G17, G18, G51, H55
Relationship between Rheological Indices and Cracking Performance of Virgin, Recycled, and Rejuvenated Asphalt Binders and Mixtures
Authors: Kaseer Fawaz , Martin Amy Epps , Arámbula-Mercado Edith
Published: May 2021

Long-term cracking performance of asphalt mixtures is heavily influenced by asphalt binder rheology, and changes in binder stiffness, ductility, and aging condition significantly affect the cracking resistance of the corresponding asphalt mixture. This study evaluated the effectiveness of several common and recently developed binder rheological indices in capturing the effects of binder performance grade (PG) and source, recycled binder content, recycling agent (rejuvenator) dose, and long-term aging. These binder rheological indices included the Superpave intermediate-temperature PG (PGI), the Glover-Rowe (G-R) parameter, the crossover temperature (Tδ = 45°), the rheological index (R-value), and ΔTc. This study also directly compared the binder rheological indices with the cracking performance of corresponding asphalt mixtures to explore possible correlations and their robustness. Asphalt mixture cracking performance was evaluated using the Illinois Flexibility Index Test (I-FIT) for intermediate-temperature cracking, and the disk-shaped compact tension (DCT) test and the uniaxial thermal stress and strain test (UTSST) for low-temperature cracking.

Results indicated that all the binder rheological indices (except PGI) consistently captured the effects of binder blend composition and proportions and aging condition, with a few exceptions. Results also showed that the G-R parameter, the crossover temperature (Tδ = 45°), and ΔTc had the best correlation to asphalt mixture and field core cracking performance as compared with other rheological indices (PGI and R-value), with ΔTc demonstrating the overall best correlation to mixture cracking performance.
Path-Based Dynamic Vehicle Dispatch Strategy for Demand Responsive Transit Systems
Authors: Shen Shiyu , Ouyang Yanfeng , Ren Shuai , Zhao Luyun
Published: May 2021

Demand responsive transit (DRT) has the potential to provide passengers with higher accessibility and lower travel time as compared with conventional transit, and at the same time make more efficient use of vehicle capacity than traditional taxi. In many current systems, vehicles are assigned to passengers along travel paths that are chosen myopically. When information on future demand distribution is available, it would be more beneficial to dispatch transit vehicles strategically to areas with a higher probability of generating passengers. This paper proposes a mathematical model for a dynamic DRT vehicle dispatch problem. It determines in real time how the operating vehicles shall be used to serve arriving passenger demand, and which paths the vehicles should choose to achieve a balance between operator and passenger costs. The model is solved by an approximate dynamic programming (ADP) based solution approach. Case studies, including a hypothetical numerical example and a real-world case in Qingdao, China, have been conducted to demonstrate the applicability of the proposed modeling framework. Results show that the proposed ADP solution can significantly improve the overall system performance as compared with myopic benchmarks.
Case Study of Social Sustainability Practices in U.S. Small Hub Airports
Authors: Marete Caroline K. , Johnson Mary E.
Published: May 2021

Airports have economic, environmental, and social impacts on communities. Many of these impacts are influenced by airport management decisions. Airport sustainability may be thought of as having four primary areas: environmental, economic, operational, and social. The objective of this study is to understand better the adoption of social sustainability practices in small hub airport planning in the United States. The small hub airports in this study participated in the Federal Aviation Administration Airport Improvement Program for sustainability planning and have published their sustainability plans as either standalone sustainability management plans or integrated sustainable master plans. Plans from the six airports were gathered and examined as part of an exploratory case study analysis. The findings show that small hub airports do not use the same framework or select the same practices for social sustainability. Social sustainability practices for these six small hub airports focus on four stakeholder categories: passengers and travelers, employees, communities and local businesses, and concessionaires and tenants.
Cordon-Based Pricing Schemes for Mixed Urban-Freeway Networks using Macroscopic Fundamental Diagrams
Authors: Wang Xuting , Gayah Vikash V.
Published: May 2021

The development of traffic models based on macroscopic fundamental diagrams (MFD) enables many real-time control strategies for urban networks, including cordon-based pricing schemes. However, most existing MFD-based pricing strategies are designed only to optimize the traffic-related performance, without considering the revenue collected by operators. In this study, we investigate cordon-based pricing schemes for mixed networks with urban networks and freeways. In this system, heterogeneous commuters choose their routes based on the user equilibrium principle. There are two types of operational objective for operating urban networks: (1) to optimize the urban network’s performance, that is, to maximize the outflux; and (2) to maximize the revenue for operators. To compare those two objectives, we first apply feedback control to design pricing schemes to optimize the urban network’s performance. Then, we formulate an optimal control problem to obtain the revenue-maximization pricing scheme. With numerical examples, we illustrate the difference between those pricing schemes.
Incidental prostate cancer in patients who underwent radical cystectomy for high risk non muscle invasive bladder cancer: Is it clinically significant?
Authors: Fragkoulis Charalampos , Glykas Ioannis , Mari Victoria , Lamprou Stavros , Tzelves Lazaros , Stathouros Georgios , Papadopoulos Georgios , Ntoumas Konstantinos
Published: May 2021

Introduction and objective:

Non muscle invasive, high-risk, bladder cancer is an entity which is usually treated with radical cystectomy. Incidental prostate cancer refers to prostate cancer detected in radical cystectomy specimens in patients with no signs of the disease. Objective of this study is to report the prevalence, characteristics, and clinical significance of incidental prostate cancer in non-muscle invasive bladder cancer patients treated with radical cystectomy in our department.

Material and methods:

We retrospectively reviewed data from 41 patients who underwent radical cystectomy for non-muscle invasive, high risk, bladder cancer during the years 2016–2020 in our department. Prostate cancer was described as clinically significant when there were positive surgical margins, extraprostatic extension, Gleason score >6, or tumor volume ⩾0.5 cm3. Two groups of patients were formed according to the presence or absence of clinically significant prostate cancer.

Results:

Incidental prostate cancer in the cystectomy specimens was detected in 21 of the 35 patients investigated. Clinically significant prostate cancer was detected in five patients. Positive surgical margins and extraprostatic extension were present in one patient, respectively. Gleason score was more than six in four of the five patients and PCa tumor volume was above 0.5 cm3 in three patients. Two patients with clinically significant prostate cancer were diagnosed with biochemical recurrence during their follow up.

Conclusions:

In non-muscle invasive, high-risk patients undergoing radical cystectomy, clinically significant incidental PCa is an important issue as it may affect prognosis, quality of life, metastasis free survival, and overall survival.
The Treatment Effect of Business Education on the Supply of High School Entrepreneurs in Atlanta and New Orleans
Authors: Price Gregory N. , Surprenant Chris W.
Published: May 2021

Strengthening the pathway to entrepreneurship for high school students could be important in regions of the United States where economic mobility is low. We examine the impact of high school business education on the decision to be a self-employed entrepreneur in two southeastern urban U.S. high schools. We appeal to a potential-outcomes framework to estimate the treatment effect of having taken a business and coding/programming course in high school on actually being a self-employed entrepreneur, and planning to do so in the future. We find evidence that having taken a business course in high school increases the likelihood of actually being a self-employed entrepreneur, and on planning to be one in the future. Our results suggest that, at least in Atlanta and New Orleans, urban high school business education can be effective in increasing the supply of entrepreneurs, which could improve economic mobility in these urban regions.

JEL Classification: C14, C21, E10, I26, J01, J20, J40, M13
Short-Term Impact of Social Distancing Measures During the COVID-19 Pandemic on Cognitive Function and Health Perception of Brazilian Older Adults: A Pre-Post Study
Authors: Almeida Pedro H. T.Q. , Bernardo Lilian D. , Pontes Tatiana B. , Davis Jane A. , Deodoro Tainá M. S. , Ferreira Rafaela G. , Souza Klysna I. , MacDermid Joy C.
Published: May 2021

Social distancing, a critical measure to manage COVID-19 transmission, is consistently associated with social isolation, a major health issue. Social isolation negatively impacts mental and physical health, particularly among older adults. A pre-post comparison study examined changes in cognitive function and perceived health among 36 community-dwelling Brazilian older adults, assessed pre and post social distancing measures enacted due to COVID-19. A significant increase in cognitive function was found 1 month into social distancing ( M = 16.3, p = .002, power = 0.88), with declining scores for vitality ( M = −29.3, p < .001, power = 0.99) and mental health ( M = −38.1, p < .001, power = 0.99), particularly among participants who lived alone ( t = −3.8, p = .001). Older adults exhibit rapid changes in perceived health when excluded from participation in social activities. Health care professionals should consider holistic approaches when addressing the impacts of social isolation on this population.
Older Adults’ Behavior Intentions Once a COVID-19 Vaccine Becomes Available
Authors: Callow Michael A. , Callow Daniel D.
Published: May 2021

Background:

The purpose of this study was to examine the impact of antecedent variables on older adults’ intention to get a CORONAVIRUS DISEASE-2019 vaccine. Older adults are at higher risk of severe illness from the disease and face an increasingly ageist general population who misrepresent the pandemic as an older adult problem. We use the Theory of Planned Behavior framework to examine vaccine behavior intention.

Method:

A convenience sample ( n = 583) of adults aged 60 and older in the United States participated in an online survey using vignettes. Hierarchical regression and analysis of covariance were used to test our model.

Results:

Results suggest that perceived risk of the pandemic, general vaccine beliefs, and political affiliation influence respondents’ attitude toward the vaccine. Respondents’ attitudes toward the vaccine and their physician’s recommendation help shape vaccine intention.

Conclusion:

The results provide partial support to the proposed model in shaping vaccine intention among older adults.
Depth of penetration of Dyneema® HB26 hard ballistic laminates
Authors: Haque Bazle Z (Gama) , Gillespie John W
Published: May 2021

Analysis of depth of penetration (DoP) experimental data of Dyneema® HB26 hard ballistic laminates is presented using an energy approach. Several DoP experimental parameters have been identified and calculated including the threshold velocity of penetration ([Formula: see text]), the characteristic time ([Formula: see text]), the DoP damping coefficient ([Formula: see text]), and the dynamic pressure per unit impact speed ([Formula: see text]). For the first time, a simple penetration model is developed from the energy approach to predict the projectile motion and penetration resistance force during depth of penetration experiments.
Return-On-Investment for Billable Pharmacist-Provided Services in the Primary Care Setting
Authors: Tran Thuy , Moczygemba Leticia R. , Musselman Kerri T.
Published: May 2021

Background:

Pharmacists are increasingly fulfilling roles on primary care teams, yet business models for pharmacist services in these settings have not been optimized. This study describes how an ambulatory care pharmacy department implemented various billing methods to generate revenue for pharmacist services.

Objectives:

(1) Describe pharmacist-delivered billable and non-billable services; and (2) Assess the impact of various billing methods on the return-on-investment (ROI) for billable services.

Methods:

This study was conducted from September 2016 to August 2017 in Virginia. Pharmacist time spent performing billable encounters using current procedural technology (CPT) codes (e.g., incident-to a physician, annual wellness visits) was calculated. Encounters eligible for the hospital-based facility (G0463) and chronic care management (CCM) codes were considered to be potentially billable services. The ROI was calculated for billable and potentially billable services.

Results:

A total of 948.3 hours (0.46 full-time equivalents (FTE)), 17% of all clinical services, were billed using CPT codes. This resulted in a total revenue of $173,638.66. Missed revenue from not billing for the G0463 and CCM codes was $68,268.37. The cost of pharmacist services for 0.46 FTE was $78,613.08, resulting in a ROI for billed pharmacist services of 1.2:1. The ROI increased to 1.6:1 when considering potentially billable services.

Conclusion:

It is feasible to have a positive ROI for billable pharmacist services. To achieve a sustainable business model, there must be a high volume of billable services. G0463 and CCM codes are often underutilized, yet represent significant opportunities in revenue for pharmacist services and should be pursued.