bluuebunny/crossref_metadata_2025 huggingface dataset:
Kişilerde Dentofasiyal Estetik Algının Psikososyal Etkileri
Authors: Kürklü Arpaçay Duygu , Başer Aysel , Kılıç Osman Hasan Tahsin
Published: March 2024

Diş hekimliğinde dentofasiyal estetik, dental ve gingival dokuların sağlığı, bunların yapısal uygunluğu, gülme anında diş, dişeti ve kaslar arasındaki ilişki ve tüm bu faktörlerin fasiyal bütünlük içinde uyumlu olmasına bağlıdır. Günümüz modern toplumunda birçok insan için dentofasiyal estetiğin iyileştirilmesi için diş hekimlerine başvuruların arttığı gözlenmektedir. Bireyler nasıl göründüklerini, başkaları tarafından nasıl algılandıklarını önemsemekte ve bu görünümlerini iyileştirmek için çok fazla zaman, para ve emek harcamaktadırlar.

Diş hekimliği’nde diş ve yüz estetiği algısının psikososyal etkilerini ölçmek, teşhisi ve tedaviyi yönlendirecek olmasından kaynaklı oldukça önemlidir. Bu amaçla ülkemizde dental estetiğin psikososyal etkisini ölçmekte faydalanılan Türkçe geçerlilik ve güvenirlik çalışması yapılmış yalnızca PIDAQ ölçeği bulunmakta olup, bu ölçeğe alternatif tutum ölçekleri geliştirilmesi gerektiği düşünülmektedir.
Donör graft hepatosteatozunun yetişkin canlı donör karaciğer nakli alıcılarında ameliyat sonrası komplikasyonlara etkisi
Authors: Anılır Ender , Sönmez Topcu Feyza , Şahin Emrah , Oral Alihan , Güzelaltunçekiç Esra , Dirican Abuzer , Ünal Bülent
Published: March 2024

Giriş ve Amaç: Steatoz, greft fonksiyonunu değişen derecelerde etkileyen ve marjinal greft yetmezliğine neden olan günümüzün önemli ve yaygın donör karaciğer problemlerinden biridir. Çalışmamızda, greft steatozunun postoperatif komplikasyonlara etkisini inceledik. Gereç ve Yöntem: Çalışmaya 148 donör ve transplantasyon yapılan yetişkin canlı donör karaciğer nakli alıcısı dahil edildi. Perioperatif kan ürünü transfüzyonu, postoperatif safra komplikasyonları, hepatik ven trombozu, portal ven trombozu, postoperatif kanama, sepsis ve primer greft disfonksiyonu sayıları ve oranları istatistiksel olarak analiz edildi. Bulgular: Ameliyat sonrası erken dönemde intraabdominal kanamanın yağlı greftlerde oran olarak, yağsız greftlere göre daha sık olduğu görüldü. Donör greft steatozu olan ve olmayanlar arasında tüm parametreler açısından istatistiksel olarak anlamlı fark yoktu. Sonuç: İstatistiksel olarak anlamlı olmasa da yağlı greftlerde ameliyat sonrası intraabdominal kanama oranının yüksek olması önemli bir bulgu olabilir.
Space Development in Housing Estates in Terms of Possibilities of Use by Seniors on the Example of the Lublin Housing Cooperative
Authors: Trzaskowska Ewa
Published: March 2024

Changes taking place in society in terms of age structure, needs and housing preferences mean that space requires constant modernization. A large proportion of elderly people in Poland live in housing estates built between 1960 and 1980. The majority of them do not want to leave them due to the location, transport connections, and also because living in a nursing home in Poland is the last resort. It is worth enabling seniors to stay in these places because their good condition requires maintaining independence. The adaptation of housing estates should include spaces that encourage physical activity to improve fitness or take preventive measures. The areas where the largest percentage of elderly people in Lublin live were selected for the study. The aim of the article is to determine the adaptation of housing estate areas to meet the recreational needs of seniors. The development of public spaces and greenery in housing estates, as well as the modernization processes that were carried out to make the areas more attractive to meet recreational needs, are presented. The standard of development of the studied estates is varied, but each of them has a strong advantage of greenery, allowing contact with nature, and places conducive to social contacts, enabling and encouraging activity.
EXPERIMENTAL AND NUMERICAL INVESTIGATION OF A DEFICIENT STORMWATER DRAINAGE SYSTEM
Authors: Yılmazer Cem , Çelik Ahmet Ozan
Published: March 2024

In this paper, a deficient stormwater system was investigated with experimental and numerical methods. The main goal was to obtain an experimentally validated 3D computational fluid dynamics (CFD) model to identify the problems of the system and offer design solutions via numerical modeling. A scaled physical model of the structure was built for CFD validation. The validation was done via comparisons of point pressure statistics, discharge and water levels. Different mesh structures and turbulence closure methods were also tested for verification of the model. The validated model was then used to determine the cause of the problems in the structure. New geometries were tested numerically to suggest solutions to the detected problems. Empirical approaches and also regulations for the stormwater structures were also considered for comparison. Findings of this study suggest that a verified and validated CFD model is an effective tool to investigate special geometries for specific hydraulic structure problems where conventional approaches are insufficient.
“Johnny Come Lately” – An Essay on Latter-Day Myths about Rural Crime and Justice Studies
Authors: Donnermeyer Joseph F.
Published: March 2024

“Johnny Come Lately” is a colloquialism with roots backs to nineteenth century British maritime days. It is used here to illustrate the recent emergence of new myths about rural crime and justice studies. As rural crime and justice studies have emerged and grown over the previous 50-plus years, a number of scholars have discussed and debunked myths about crime and rurality, but unfortunately, new falsehoods have been purposively created of late. In this paper, each latter-day myth is described, debunked and then transformed into positive directives about the future of rural crime and justice studies, following the example set by Ceccato and Abraham (2022). These positives include: (1) there must be a sustained effort to make the location for rural crime studies and the scholars who do the research and theorizing ever more diverse; (2) rural crime studies, both old and new, must be made more easily accessible to this generation and future generations of scholars, practitioners and policy-makers alike; (3) rural crime studies must continue to improve theoretical sophistication through application, critique, and revision, and through theoretical interpretation of previously published empirical work; and (4) a thorough synthesis of the rural crime and justice studies literature is imperative to its future development.
A Nineteenth Century Rural Crime in Western Queensland?
Authors: McBride Graham
Published: March 2024

In August 1895, Andrew Barton “Banjo” Paterson was visiting his fiancée at Dagworth Station near Winton in western Queensland, Australia, when he was moved to write a bush ballad that became more prominent than even he might have expected. The question arises as to what was or were the circumstances or events that stimulated the creative mind of Paterson to write such a spirited ballad. A rural crime was certainly committed down by the billabong in the ballad, but there were real events playing out throughout the western sheep grazing country of Queensland at that time and had been for some years. This research note argues that, in identifying crimes, we can observe a dichotomy of opposites with some boundaries being contained, while others are large and fluid. Each have a particular fragility as well as a strength. Contained boundaries have a placement that has strength, but vulnerability to encroachment by powerful forces: the need to protect is ever present. It is also argued that this ballad, which contextualises a rural crime, serves as an allegory symbolising a sense of injustice, of resistance against injustice and excessive use of power.
Changes in the Metabolism of Fucose-Containing Biopolymers in Rat Gastrointestinal Tissues under Immobilization Stress
Authors: Oksuzyan A.V. , Butolin E.G. , Bryzgalina A.A.
Published: March 2024

The features of fucoglycoprotein metabolism in blood serum and tissues of gastrointestinal tract of rats in the dynamics of experimental stress on 21, 35, 60, 90 days of observation were considered. In blood serum and in homogenates of liver, stomach and small intestine of immobilized rats multidirectional changes in the level of fucose and fucosidase activity were observed. They are manifested by a decrease in the amount of total fucose in blood serum and liver of rats against the background of low activity of the enzyme degrading fucoglycoproteins. The same changes were detected in the tissues of the gastric and small intestine (except on day 35 of the experiment, when the growth of fucose and fucosidase was visualized), which may indicate a change in metabolism toward anabolism. These changes correlate with an increase in the concentration of corticosterone in the blood serum of the rats.
Answer to Viva Question in Histology
Authors: Kulkarni Jyoti P , Paranjpe Vaishali , Vatsalaswamy P
Published: March 2024

First year MBBS students find it difficult to understand the microscopic anatomy of various structures. It is further more difficult for the students to comprehend the structural and functional correlation of these structures. Microscopic anatomy forms the edifice of pathology, medicine and all surgical branches. This book has been written i question and answer format wherein each chapter in histology has been split into questions and answers.This will enable the students to understand and memorise the microscopic structure and structural functional correlation, thereby helping them to prepare thoroughly for the Viva as well as theory examination in histology in first year MBBS.
A Textbook of Medical Genetics and Cancer Genetics
Authors: Kalpana Dr. V. Lakshmi , Anuradha Dr. A.
Published: March 2024

The book deals with genetics of the various disorders at the molecular level and discusses their prognostic, diagnostic and management/treatment aspects.
Cancer is detailed in the perspective of genetics i.e., the alteration of proto-oncogenes and oncogenes at the cellular level.
This book provides better insight into the genetic disorders and inherited versus familial cancers.
This book will benefit Postgraduate students of both Human genetics and Medicine to develop an understanding of Medical Genetics.
A retrospective analysis of anesthetic techniques and their related perioperative complications in children undergoing cochlear implant surgeries – our preliminary experience at a tertiary care referral centre
Authors: Puri Kriti , Kundal Raksha , Varshney Preeti Goyal , Chandra Vidhi , Pandey Maitree , Kumar Sunil
Published: March 2024

: Cochlear implants serve as a favorable option for treatment of hearing loss in children. However, there is limited data regarding the type of anesthetic techniques used and its associated complications in such patients. Hence, the primary objective of this study was evaluation of postoperative nausea vomiting (PONV) with three different general anesthesia techniques in pediatric cochlear implant surgeries. The secondary objectives included assessment of intraoperative and postoperative complications

: A retrospective analysis of all children less than 13 years, who underwent cochlear implant surgery at our hospital between December 2019 to February 2022 was performed. Appropriate data were noted. Nine patients each were classified into three groups (Group A, B and C) on the basis of anesthetic techniques used in our institution. Group A received inhalational agent for induction and maintenance, with no Non-Depolarizing Muscle Relaxant (NDMR), Group B patients received Total Intravenous Anesthesia with NDMR and Group C received intravenous induction and inhalational agent for maintenance with NDMR.

Twenty-seven patients were included. There were no major intraoperative complications. PONV was noticed in two patients of Group A and one patient of Group C. One patient belonging to Group A developed laryngospasm and desaturation. Delayed Awakening was seen in one patient each of Group A, B and C. Overall, four complications were noted in patients of Group A, one in Group B and two in Group C. All complications were mild and were managed successfully.

This preliminary study suggests that peri-operative anesthetic complications with all three anesthestic techniques were comparable and safe.
Factors influencing decision-making for the anesthetic technique in molar pregnancy patients for suction curettage: A retrospective study
Authors: Triyasunant Namtip , Nivatpumin Patchareya , Luangpirom Nutthakarn , Wongwananurak Thanyarat
Published: March 2024

Anesthetic techniques for suction curettage in molar pregnancy patients described in the literature can be classed into general anesthesia and regional anesthesia techniques. The aim of the present study was to report the factors influencing the decision-making for the choice of anesthetic technique in molar pregnancy patients who underwent suction curettage at Siriraj Hospital. The reported intraoperative and postoperative complications were also analyzed.

A retrospective chart review was conducted among pregnant women diagnosed with molar pregnancy who had underwent suction curettage under anesthesia at Siriraj Hospital between January 2007 to September 2021. Overall, 244 patients were diagnosed with molar pregnancy, with 110 of these included for analysis in this study after consideration of the inclusion and exclusion criteria. Quantitative data of the included patients were analyzed by either unpaired t-test or Mann–Whitney U test, while qualitative data were analyzed by the chi-square test. Logistic regression was used to establish the factors influencing the decision-making for the anesthetic technique.

General anesthesia was the most preferred anesthetic technique (77.4%) in the molar pregnancy patients who had underwent suction curettage, followed by regional anesthesia (11.3%) and intravenous sedation (11.3%). General anesthesia was likely to be used in patients with an enlarged uterine size ≥ 16 weeks with an adjusted odds ratio of 11.64 (95% CI 1.08–125.72, p < 0.05). Patients with a larger uterine size were associated with higher beta-hCG levels, resulting in more severe medical complications, such as hyperthyroidism and hyperemesis gravidarum (p < 0.05). Intraoperative complications, such as uterine atony (17.7%), massive hemorrhage (7.3%), and pulmonary edema (4.2%), were confined within patients receiving general anesthesia, but there was no statistical significance. None of the patients had anesthesia-related complications. The reported postoperative serious complications, such as pulmonary edema (4.2%), which required postoperative intubation and transferal to the intensive care unit, were all in the general anesthesia group.

Patients with higher co-morbidities were advised by anesthesiologists to receive general anesthesia. However, an enlarged uterine size ≥ 16 weeks was the only factor that had an influence on the decisions of the anesthesiologists to provide general anesthesia.
Clinical assessment of recovery from neuromuscular blockers, is it a safe practise - An observational study
Authors: Shaji Govind , Mishra Gayatri
Published: March 2024

The incidence of residual neuromuscular paralysis (RNMB) with Train of four ratio<0.9 remains as high as 16% in PACU even after administration of reversal when neuromuscular monitoring is not done. Reversal with standard dose of neostigmine and extubation are done based on the clinical signs. We observed the clinical signs of neuromuscular recovery and correlated with neuromuscular monitoring to assess the degree of residual blockade in the post-operative period.

100 Patients posted for surgery under general anaesthesia with endotracheal tube intubation and controlled ventilation were enrolled for the study after obtaining human ethical approval. Standard anaesthesia technique using morphine, propofol, vecuronium, isoflurane with low flow anaesthesia were administered for all patients. TOF was noted at the end of surgical procedure when patient resumed spontaneous respiration, during extubation, and at 15 minutes interval for one hour in the postoperative period. Hemodynamics were observed including respiratory rate.

Overall 32 percent of patients had residual paralysis. 27% at 15 min, 26% at 30min, 6% at 45min and 3% at one hour in the postoperative period showed RNMB. Subgroup analysis showed that at the time administration of reversal 72 patients had (TOFR>0.4) and 28 had (TOFR<.0.4), showed significant difference in improvement in TOFR between 2 subgroups before reversal, immediate extubation and 15 min post extubation (p=0.00,0.001,0.003,) respectively.

Clinical findings of neuromuscular reversal is not foolproof for complete recovery and standard dose neostigmine given during shallow block will accentuate the residual neuromuscular paralysis.
A questionnaire-based survey of perioperative utilisation of ultrasound among anaesthesiology residents
Authors: Kukanti Chandini , Natarajan Pharanitharan
Published: March 2024

: Ultrasonography (USG) is a resourceful tool in the perioperative period. A structured training curriculum during residency can enhance the utilisation of USG among residents.

: This cross-sectional online survey was conducted to evaluate the utilisation of USG in the perioperative period and to assess the adequacy of current training.

: A questionnaire was formatted consisting of 15 questions. The questionnaire was sent to the participants through email or any electronic mode of communication. This was an electronic survey conducted after obtaining informed consent from the participants.

: It was found that although the availability of USG has increased, its use in the perioperative period is limited due to various factors such as time constraints. The adequacy of training is significantly different depending on the frequency of training (p-value < 0.01). The majority of the residents (N=82, 81.2%) felt that they needed more training in the utilisation of USG.

: Integration of a structured training curriculum in USG as a part of anaesthesiology residency can aid in enhancing patient care in the perioperative period.
Carcinoid syndrome: Innovative anesthetic approach utilizing erector spinae plane block
Authors: Sood Ojaswani Rai , Salim Mohmad
Published: March 2024

A 57-year-old female with history of carcinoid syndrome along with extensive liver metastases presented for a right sided mastectomy and implant insertion for breast cancer. Preoperative optimization included an octreotide infusion and anxiolysis, as well as planning a cardiostable anaesthetic that avoided any crisis stressors. Ultrasound guided thoracic (T4) ESP block using 0.2% Ropivacaine was given under propofol sedation followed by remifentanil and propofol anaesthesia. Octreotide infusion along with boluses was used to treat hypotension and bradycardia intraoperatively. The combination of perioperative octreotide administration, intraoperative remifentanil and propofol anaesthesia and ESP block provided satisfactory anaesthesia. The block was effective for 36 hours post-operatively and the patient was discharged 48 hours post admission. We suggest that a novel interfascial plane block, ESP block is a useful addition to the armamentarium of the anaesthetist in the management of a patient with carcinoid syndrome with an aim to decrease dependence on morphine and preventing conversion to chronic pain.
Anaesthetic management of a case of Takayasu arteritis: A case report
Authors: Wadhwa Rachna , Naqvi Ehtesham , Keshav Suman , Virmani Sanjula
Published: March 2024

Takayasu's arteritis (TA) is a rare disease characterized by chronic progressive pan-endarteritis involving large blood vessels with resultant feeble pulsations in involved arteries. Therefore, it is also referred as pulseless disease. The challenges for anaesthesia management includes uncontrolled hypertension, invasive arterial monitoring, central nervous system monitoring and end-organ dysfunction. We present successful management of a middle-aged female diagnosed with TA posted for aorto-carotid graft. The anaesthesia management and complications encountered are highlighted.
Study the effect of Vitamin D3 in newly diagnosed acute myeloid leukemia
Authors: Obed Fatma Abdalhamza , Shatha M. J. Al-Khateeb  , Akram Raghada Shams , Ali Kareem Mohammad
Published: March 2024

This study is aimed to put light on the effect of vitamin D3 (VitD3) in newly diagnosed acute myeloid leukemia (AML) patients.

The AML patients consisted of sixty patients (30 male, 30 female). The average age of patients was (36.44±8.44) years (range 25-45). Thirty healthy subjects were considered as controls (15 male and 15 female), and the average age of control group was (32.22±5.13) years. All subjects had to go through clinical examination to determine existence of other diseases in addition to evaluate some tests as complete blood count [hemoglobin (Hb), platelet (PLT), and white blood cells (WBCs)], ferritin, FBS (fasting blood sugar), TG (triglycerides), TC (total cholesterol), and HDL (high density lipoprotein cholesterol) (HDL-Ch), urea, and creatinine. Vitamin D3 was measured by minividase Biomerux/French.

The VitD3 was highly significantly lower in AML patients than in controls (p=0.001). While, VitD3 was lower in male than in female AML patients but the difference was not statistically significant. There were statistically significant positive correlations between VitD3 and Hb, PLT, Wbc, ferritin, FBS, and TG in both male and female AML patients.

These findings suggest that lower serum concentrations of vitamin D3 may possibly be considered as a potential factor for early assessment of acute myeloid leukemia.
Formulation and evaluation of aceclofenac fast disintegrating tablets using sida acuta powder
Authors: Anjali T , Prasanna Kumar P.SS , Srinivas N. , Shivaji K.
Published: March 2024

Aceclofenac is a NSAID with anti-inflammatory, analgesic activity. The aim is to develop the Aceclofenac tablets with sida acuta powder that exhibit rapid disintegration, dissolution and showing maximum pharmacological activity in less time. This is desirable for improving patient compliance. The present study was to formulate and evaluate the fast-disintegrating tablets of Aceclofenac using Sida acuta powder by direct compression technique with varying concentrations. Each formulation was evaluated for pre and post evaluation tests such as Flow property, Bulk density, tapped density, Weight variation, Hardness, Friability, Wetting time, Disintegration time, Assay, in-vitro dissolution. Among the 06 formulations, F6 formulation Aceclofenac with 6%w/w of Sida acuta showed the in-vitro dissolution (99.75%) release of drug within 20 minutes and release of drug mechanism as first order kinetics. It was concluded that the fast-disintegrating tablets are prepared by Natural polymer Sida acuta acts as a disintegrant and showed excellent disintegration time,enhance the dissolution rate.
Algorithm of automatic identification of diabetic retinopathy foci based on ultra-widefield scanning laser ophthalmoscopy
Authors:   Aier Eye Hospital (East of Chengdu), Chengdu 610051, Sichuan Province, China, Wang Jie , Qin Xiao-Lin ,   Aier Eye Hospital (East of Chengdu), Chengdu 610051, Sichuan Province, China, Chen Meng ,   Aier Eye Hospital (East of Chengdu), Chengdu 610051, Sichuan Province, China, Zhang Heng-Ming ,   School of Computer and Artificial Intelligence, Southwest Jiaotong University, Chengdu 610097, Sichuan Province, China, Liu Xin ,   Aier Eye Hospital (East of Chengdu), Chengdu 610051, Sichuan Province, China, Xiang Meng-Jun ,   Aier Eye Hospital (East of Chengdu), Chengdu 610051, Sichuan Province, China, Hu Jian-Bin ,   Chengdu Aier Eye Hospital, Chengdu 610041, Sichuan Province, China, Huang Hai-Yu ,   School of Computer and Artificial Intelligence, Southwest Jiaotong University, Chengdu 610097, Sichuan Province, China, Lan Chang-Jun ,   Aier Eye Hospital (East of Chengdu), Chengdu 610051, Sichuan Province, China
Published: March 2024

AIM: To propose an algorithm for automatic detection of diabetic retinopathy (DR) lesions based on ultra-widefield scanning laser ophthalmoscopy (SLO).
METHODS: The algorithm utilized the FasterRCNN (Faster Regions with CNN features)+ResNet50 (Residua Network 50)+FPN (Feature Pyramid Networks) method for detecting hemorrhagic spots, cotton wool spots, exudates, and microaneurysms in DR ultra-widefield SLO. Subimage segmentation combined with a deeper residual network FasterRCNN+ResNet50 was employed for feature extraction to enhance intelligent learning rate. Feature fusion was carried out by the feature pyramid network FPN, which significantly improved lesion detection rates in SLO fundus images.
RESULTS: By analyzing 1076 ultra-widefield SLO images provided by our hospital, with a resolution of 2600×2048 dpi, the accuracy rates for hemorrhagic spots, cotton wool spots, exudates, and microaneurysms were found to be 87.23%, 83.57%, 86.75%, and 54.94%, respectively.
CONCLUSION: The proposed algorithm demonstrates intelligent detection of DR lesions in ultra-widefield SLO, providing significant advantages over traditional fundus color imaging intelligent diagnosis algorithms.
CD3ε of a pan T cell marker involved in mouse Aspergillus fumigatus keratitis
Authors:   Department of Ophthalmology, the Affiliated Hospital of Qingdao University, Qingdao 266000, Shandong Province, China; Weifang Medical University, Weifang 261053, Shandong Province, China, Shi Wen-Hao , Yan Hai-Jing ,   Department of Ophthalmology, the Affiliated Hospital of Qingdao University, Qingdao 266000, Shandong Province, China; Eye Hospital of Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, China, Liu Shi-Long ,   Department of Medical Engineering, the Affiliated Hospital of Qingdao University, Qingdao 266000, Shandong Province, China, Yang Xian ,   Department of Ophthalmology, the Affiliated Hospital of Qingdao University, Qingdao 266000, Shandong Province, China, Yang Xue-Jiao ,   Department of Ophthalmology, the Affiliated Hospital of Qingdao University, Qingdao 266000, Shandong Province, China, Che Cheng-Ye ,   Department of Ophthalmology, the Affiliated Hospital of Qingdao University, Qingdao 266000, Shandong Province, China
Published: March 2024

AIM: To explore whether CD3ε is involved in the adaptive immunity of Aspergillus fumigatus (A. fumigatus) keratitis in mice and the role of innate and adaptive immunity in it.
METHODS: Mice models of A. fumigatus keratitis were established by intra-stromal injection and corneal epithelial scratching. Subconjunctival injections of natamycin, wedelolactone, LOX-1 inhibitor (poly I) or Dectin-1 inhibitor (laminarin) were used to treat mice with A. fumigatus keratitis. Mice were pretreated by intraperitoneal injection of anti-mouse CD3ε. We observed the corneal infection of mice under the slit lamp microscope and made a clinical score. The protein expression of CD3ε and interleukin-10 (IL-10) was determined by Western blotting.
RESULTS: With the disease progresses, the degree of corneal opacity and edema augmented. In the intra-stromal injection models, CD3ε protein expression began to increase significantly on the 2nd day. However, in the scraping epithelial method models, CD3ε only began to increase on the 3rd day. After natamycin treatment, the degree of corneal inflammation in mice was significantly attenuated on the 3rd day. After wedelolactone treatment, the severity of keratitis worsened. And the amount of CD3ε protein was also reduced, compared with the control group. By inhibiting LOX-1 and Dectin-1, there was no significant difference in CD3ε production compared with the control group. After inhibiting CD3ε, corneal ulcer area and clinical score increased, and IL-10 expression was downregulated.
CONCLUSION: As a pan T cell marker, CD3ε participate in the adaptive immunity of A. fumigatus keratitis in mice. In our mice models, the corneas will enter the adaptive immune stage faster. By regulating IL-10, CD3ε exerts anti-inflammatory and repairs effects in the adaptive immune stage.
Distribution and correlation of refractive parameters in children with different corneal curvatures in southeast China
Authors:   The Second Clinical College, Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang Province, China, He Si-Yuan , Xu Meng-Yue ,   Department of Ophthalmology, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou 310014, Zhejiang Province, China, Ni Ying-Jie ,   The Second Clinical College, Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang Province, China, Hong Chao-Yang ,   Department of Ophthalmology, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou 310014, Zhejiang Province, China, Shen Ting ,   Eye Center, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, Zhejiang Province, China
Published: March 2024

AIM: To analyze the distribution of refractive status in school-age children with different corneal curvatures (CC) and the correlation between CC and refractive status.
METHODS: A total of 2214 school-aged children of grade 4 in Hangzhou who were screened for school myopia were included. Uncorrected distance visual acuity (UCDVA), non-cycloplegic refraction, axial length (AL), horizontal and vertical corneal curvature (K1, K2) were measured and spherical equivalent (SE), corneal curvature radius (CCR) and axial length/corneal radius of curvature ratio (AL/CR) were calculated. UCDVA<5.0 and SE≤-0.50 D were classified as school-screening myopia. According to the different CCRs, the patients were divided into the lower corneal curvature (LCC) group (CCR≥7.92) and the higher corneal curvature (HCC) group (CCR<7.92). Each group was further divided into the normal AL subgroup and the long AL subgroup. The refractive parameters were compared to identify any differences between the two groups.
RESULTS: Both SE and AL were greater in the LCC group (P=0.013, P<0.001). The prevalence of myopia was 38% in the LCC group and 44% in the HCC group (P<0.001). The proportion of children without screening myopia was higher in the LCC group (62%) than in the HCC group (56%). Among these children without screening myopia, the proportion of long AL in the LCC group (24%) was significantly higher than that in the HCC group (0.012%; P<0.001). The change of SE in the LCC group was less affected by the increase of AL than that in the HCC group.
CONCLUSION: School-aged children in the LCC group have a lower incidence of screening myopia and longer AL. Low CC can mask SE reduction and AL growth to some extent, and the change of AL growth change more in children with low CC than high CC. Before the onset of myopia, its growth rate is even faster than that after the onset of myopia.
Effectiveness of intravitreal ranibizumab for diabetic macular edema in vitrectomized versus non-vitrectomized eyes: a Meta-analysis
Authors:   Department of Ophthalmology, Zhongda Hospital, Southeast University, Nanjing 210009, Jiangsu Province, China; School of Medicine, Southeast University, Nanjing 210009, Jiangsu Province, China, Wang Yi-Heng , Luan Jie ,   Department of Ophthalmology, Zhongda Hospital, Southeast University, Nanjing 210009, Jiangsu Province, China
Published: March 2024

AIM: To evaluate the effectiveness and safety of intravitreal ranibizumab (IVR) for diabetic macular edema (DME) in vitrectomized versus non-vitrectomized eyes.
METHODS: The PubMed, EMBASE, Web of Science, Cochrane, EBSCO were comprehensively searched for studies comparing vitrectomized and non-vitrectomized eyes with DME. Clinical outcomes of best-corrected visual acuity (BCVA), central macular thickness (CMT), the mean number of intravitreal injection and adverse events were extracted and analyzed.
RESULTS: Six studies involving 641 eyes were included. Final visual gain significantly improved and CMT significantly reduced in vitrectomized eyes at 6mo and 12mo visits (P<0.05). Although the mean reduction in CMT among non-vitrectomized eyes was significantly greater than in vitrectomized eyes at the 6mo [mean difference (MD)=53.57, 95% confidence interval (CI): 28.03 to 78.72, P<0.0001] and 12mo (MD=49.65, 95%CI: 19.58 to 79.72, P=0.01), no significant difference was detected in improvement in BCVA at either 6mo (MD=0.05, 95%CI: -0.02 to 0.13, P=0.14) or 12mo (MD=0.03, 95%CI: -0.04 to 0.09, P=0.43). Injection number of ranibizumab in non-vitrectomized eyes was significantly less than that in vitrectomized eyes during 6-month period (MD=0.60, 95%CI: 0.16 to 1.04, P=0.008), while there was no statistically significant difference between the two groups during 12mo of follow-up.
CONCLUSION: Evidence from current study suggests that IVR was useful for both vitrectomized group and non-vitrectomized group with DME. Although less reduction in macular thickness is found in vitrectomized group, visual improvement between two groups is similar.
Estudio del índice de radiación ultravioleta en la zona Centro Occidente de México, su asociación con el riesgo de cáncer de piel y propuesta tecnológica para la difusión y prevención del riesgo
Authors: López-Saldaña Gustavo A. , Cendejas-Valdez José L. , Soto-Sumuano J. Leonardo , Benítez-Ramírez Ma. Elena
Published: March 2024

En el 2012 la Organización Mundial de la Salud (OMS) clasificó la radiación ultravioleta (ultraviolet radiation, UVR) como carcinógeno del grupo 1, ello porque existen pruebas suficientes para considerarla causa de cáncer en el ser humano. Presentamos aquí los resultados de nuestro estudio sobre la UVR en la zona Centro Occidente de México y su asociación con el riesgo de cáncer de piel, así como la propuesta de una solución tecnológica que contribuya a la difusión de este problema y ofrezca recomendaciones para su prevención. Con este objetivo, se midió y se clasificó la radiación solar ultravioleta durante un año para, posteriormente, investigar y analizar el incremento de cáncer de piel asociado a la UVR. Los resultados fueron los siguientes: a) la presencia de niveles “muy altos” de radiación ultravioleta según el índice de UVR, con un promedio anual en el 2022 de 9,0, y de 10,7 en el cuatrimestre con mayor radiación; b) la causa de uno de cada tres casos de melanoma (un tipo de cáncer de piel) en México es la exposición a la UVR; c) las fuentes secundarias evidenciaron un incremento en los casos de melanoma en México, y d) la propuesta y desarrollo de una App para la divulgación, prevención y reducción del riesgo. El trabajo se ajustó a los Objetivos de Desarrollo Sostenible 3.4 y 3.d planteados en la Agenda 2030 de la Organización de las Naciones Unidas (ONU).
¿Cómo ha evolucionado el tráfico ilegal de fauna en el Tolima? Análisis multitemporal de una amenaza para la biodiversidad
Authors: Lozano Suarez Tatiana Estefania , Bonilla-Liberato Edison D. , López-Delgado Edwin O.
Published: March 2024

El tráfico ilegal de especies es una actividad delictiva muy lucrativa que amenaza la supervivencia de numerosas especies. El departamento del Tolima, centro de Colombia, es considerado un hotspot para estas actividades debido a su rica biodiversidad y ubicación estratégica. Con el propósito de conocer el comportamiento del tráfico ilegal de fauna silvestre en este departamento, se analizó el número de reportes de incautación y entregas voluntarias entre el 2013 y el 2022 a partir de la información proporcionada por la Corporación Autónoma Regional del Tolima (Cortolima). Se registraron 4.067 individuos pertenecientes a 218 especies, 150 géneros, 96 familias y 45 órdenes. Las aves fueron el grupo más traficado (56,2 %), seguido de los reptiles (34,25 %) y los mamíferos (6,68 %). Entre las especies más afectadas se encuentran la tortuga morrocoy (Chelonoidis carbonarius), el loro común (Amazona ochrocephala) y el periquito bronceado (Brotogeris jugularis). El 9,17 % de las especies registradas están amenazadas a nivel internacional y el 8,25 % a nivel nacional, en tanto que el 35,32 % se encuentra en los apéndices de la Convención sobre el Comercio Internacional de Especies Amenazadas de Fauna y Flora Silvestres - CITES. Los años 2021 (21,63 %) y 2016 (18,28 %) fueron los del mayor número de incautaciones, mientras que el 2013 (33,91 %), el 2014 (29,32 %) y el 2015 (24,54 %) registraron el mayor número de entregas voluntarias de especies a Cortolima. La zona central del departamento fue la más representativa a lo largo del periodo estudiado (66,24 %). Estos hallazgos brindan una visión detallada y actualizada del tráfico ilegal de especies en el Tolima, lo que es esencial para diseñar e implementar medidas de conservación y protección de especies amenazadas.
Algunos elementos históricos específicos sobre la evolución de la Educación matemática como disciplina de investigación
Authors: D’Amore Bruno
Published: March 2024

En el mundo universitario italiano la denominada Educación matemática forma parte del área científica disciplinaria “MAT 04” y sus cursos se imparten en todas las universidades en distintos niveles académicos: en las facultades de ciencias y las carreras de formación de profesores de escuela primaria, así como en las maestrías y doctorados de investigación. En este artículo se trazan las líneas de la evolución histórica de la disciplina a nivel internacional y se da cuenta de sus antecedentes, en un intento por explicar cuáles son sus condiciones actuales.
Contribution of Tourism Sector to State’s GSDP with Special Reference to South Indian States - A Comparative Study
Authors: Gowtham M. P. , Shekhar B.
Published: March 2024

India is known for diversity in every aspect. The physical geography of the nation has to endeavour in tourism. For developing countries such as India, tourism has been a boon in employment creation and revenue generation. In this particular research paper, the researchers have compared the contribution of tourism to State Gross Domestic product among southern Indian states. The study was based on secondary data. The study found that the tourism sector has been consistently contributing around 6 per cent to the total GSDP of each state. Out of these, Karnataka topped in terms of revenue generation, and Tamil Nadu topped in terms of foreign and domestic visits.
Marketing Management
Authors: Sathyanarayana S.
Published: March 2024

No Abstract.
Percepção das participantes de um grupo de gestantes acerca da assistência ao pré-natal na atenção básica
Authors: Oliveira Mirelly Abrantes de , Sousa Milena Nunes Alves de
Published: March 2024

Objetivo: Avaliar a percepção das participantes do grupo de pré-natal quanto a importância de ações educativas de promoção da saúde e práticas de humanização na APS, associando-os aos aspectos sociodemográficos e antecedentes obstétricos. Metodologia: Trata-se de um estudo exploratório, com abordagem quantitativa e qualitativa, realizado na Unidade Básica de Saúde Aderban Martins, em Patos-PB, avaliando a percepção de 10 gestante sobre a experiência em um grupo de gestantes, durante o mês de março de 2024. Resultados: A faixa etária variou de 20 a 43 anos, com predominância das mais jovens, casadas ou em união estável, com nível de escolaridade maior entre o ensino fundamental e médio e renda familiar entre 1 e 2 salários-mínimos, a maioria eram multíparas, com antecedentes de partos cesáreas e não realizaram planejamento familiar. A percepção das gestantes participantes acerca da assistência ao pré-natal foi predominantemente positiva, melhorando a vivência da gravidez, proporcionando espaço qualificado para assistência integral e humanizada. Conclusão: O grupo de gestantes teve um impacto na adesão às condutas e às orientações fornecidas pelos profissionais, na assiduidade às consultas de pré-natal e maior satisfação com o serviço de saúde prestado.
Implementação de um programa de controle de peso em uma unidade básica de saúde
Authors: Ramalho Vera Lúcia , Lima Filho Amaro , Sousa Milena Nunes Alves de
Published: March 2024

Introdução: A obesidade é uma condição que pode prejudicar a saúde do indivíduo, podendo estar relacionada com um aumento do risco para desenvolvimento de doenças crônicas. Objetivo: Este estudo objetivou descrever o processo de implantação de um programa de controle de peso, como parte da avaliação de risco cardiovascular entre os usuários com hipertensão arterial sistêmica na atenção primária. Método: Este é um estudo descritivo, do tipo relato de experiência baseado na metodologia do Arco de Maguerez, em que foram descritas ações relativas à implantação de um programa de controle de peso chamado “Peso Saudável”. Resultados: A obesidade estava presente em 60% dos pacientes hipertensos cadastrados no programa, contudo, não era uma queixa frequente na consulta médica. Conclusão: Com a implantação do programa, os participantes tiveram uma maior conscientização sobre a obesidade como doença crônica e fator de risco para complicações não só entre os hipertensos, mas entre a população em geral.
Analysis of Teacher's Professional Competency in Students of Teacher Professional Education
Authors: Maydiantoro Albet , Caswita Caswita , Ridwan Ridwan , Yanzi Hermi , Agustina Eka Sofia , Zalmansyah Achril
Published: March 2024

Improving the quality of teachers should be a severe concern of universities, including the University of Lampung, by implementing higher education reforms to produce prospective teachers with good competencies. This study aimed to examine the professional competence of prospective teachers in educating students who took the Teacher Professional Education Course (PPG) at the University of Lampung. The study used a quantitative approach, using a research sample of 310 students of Teacher Professional Education (PPG) of the University of Lampung with a questionnaire data collection technique. The method of analysis used descriptive statistical analysis with the help of the SPSS-26. The results showed that PPG students in a reasonably good category were as much as 40%, 25% were in a suitable category, only 6% were in an excellent category, 5% were in an inferior category, and 24% were in the poor category. In addition, there was no difference in the competence of Teacher Professional Education (PPG) students even though they were controlled by gender, age, teaching experience, and employment status.
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Authors: . .
Published: March 2024

No abstract.
Investigation of Earthquakes in Turkey with Cluster Analysis
Authors: Şen Ahmet Murat , Yıldız Zeki
Published: March 2024

In this study, earthquakes with a magnitude of 3 and above occurring between 36-42 degrees North latitude and 26-45 degrees East longitude, within and around Turkey from 1980 to 2022, were considered. Turkey and its immediate surroundings were divided into 114-unit squares using latitude and longitude coordinates to investigate seismic similarities. The variables including 50130 earthquake depths and magnitudes in our data set were analyzed using the {K-Means Cluster Analysis} method in the SPSS program. Hierarchical clustering method was used to determine the number of clusters and the number of clusters was determined as 5 with the help of the dendrogram obtained. As a result of the cluster analysis, it was observed that 47% of the earthquakes in Turkey were at a depth of 5 to 10 km. It has been observed that 93% of the earthquake intensities occur between 3 and 4 magnitudes. A cluster analysis was conducted to assess the similarities and dissimilarities among earthquakes within these unit squares in terms of their magnitudes and depths. Due to the large sample size and the analysis involving continuous variables, the earthquake data were grouped into 5 clusters using non-hierarchical clustering methods, and the relationships within and between these clusters were observed.
Perancangan Dan Implementasi Aplikasi Penunjang Dalam Melakukan Audit (Studi Kasus Uin Syarif Hidayatullah Jakarta)
Authors: Kesuma Mezan El-Khaeri , Mathar Fadhilah , Agustin Fenty Eka Muzayyana , Farah Wilda , Brilliant Muhamad , Astuti Tiara Widi
Published: March 2024

Nowadays, various government agencies/institutions have realized how important the role of information technology is in getting data and information from around the world quickly, precisely and accurately.  One of them is in supporting and assisting in the efforts of Auditing the Management of State Financial Responsibilities.  The State Islamic University (UIN) Syarif Hidayatullah carries out its routine activities, namely conducting State Finance Inspections, Planning and Accountability (Audits) starting from SPI (Intern Auditor) to the Inspectorate General (Itjend) Ministry of Religion (Kemenag) and the Financial Supervisory Agency (BPK), here the researchers provide solutions that is, one way is to use a Supporting Application in conducting an audit. The purpose of this application is to increase efficiency, effectiveness, and transparency in the Audit of State Finance Accountability Management because this is one of the characteristics of Good Government / Good Cooperate Government.  The results of this study: (1) can facilitate the activities of the Audit and Management and Accountability of State Finances;  (2) preventing the occurrence of fraudulent KKN (Corruption practices;  (3) the existing funds are also expected to improve student services at UIN Jakarta.
Rancang Bangun Sistem Informasi Rapor Online Berbasis Web Pada TPQ Al Hidayah Menggunakan Metode Waterfall
Authors: Ernawati Siti , Kusumawati Novi
Published: March 2024

Sistem pengisian rapor pada TPQ Al Hidayah masih menggunakan cara yang manual yaitu wali kelas memberikan nilai pada murid, lalu mencatatan nilai murid satu persatu dan melakukan akumulasi nilai menggunakan kalkulator dan mencatat nilai, hal ini sangatlah kurang efektif karena jumlah murid yang ada pada TPQ Al Hidayah kurang lebih terdiri dari 85 orang. Selain itu proses manual yang dilakukan juga memakan banyak waktu dan sering terjadi kekeliruan dan kehilangan pada pencatatan nilai murid. Dikarenakan hal tersebut penulis membuat rancangan sistem informasi rapor online berbasis web agar lebih mempermudah proses pengerjaan dan pencatatan rapor murid pada TPQ Al Hidayah. Dalam hal ini bahasa pemrograman yang penulis gunakan adalah PHP, perangkat lunak yang penulis gunakan yakni xampp, sublime dan dalam hal ini framework yang digunakan adalah codeigniter. Metode yang digunakan untuk membangun sistem informasi yakni waterfall. Penggunaan Sistem Informasi Rapor Online Berbasis Web ini terbukti lebih mempermudah sistem kerja yang ada pada TPQ Al Hidayah dan waktu yang digunakan menjadi lebih singkat, sehingga guru/wali kelas dapat menggunakan waktu yang lebih luang untuk materi tambahan dan persiapan pembagian rapor.
Stability of Charge
Authors: Trivedi Nripesh
Published: March 2024

Electricity is fire as electricity produces heat and light which are the properties of fire. Electricity has charge. Thus, charge is also fire or fire is charge. Stability of charge is given by temperature. This could be verified from applications in daily life such as making of bricks at high temperature, storage of heated water in thermos flask or simply for keeping the fire burning one needs temperature. Thus, it could be seen that stability of charge is given by temperature since fire is charge (as described above).
As shown in [1] source of fire is mass, thus temperature could be used to make strong and stable mass since stability of charge contained inside the mass is temperature.
Strength of Mass
Authors: Trivedi Nripesh
Published: March 2024

Electricity is generated by magnet as described in [1]. It produces heat and light which are the properties of fire. Thus, electricity is fire. Since electricity is generated by magnet [1], electricity is magnetic. Since electricity is fire, thus fire is also magnetic. The energy of the mass is fire as described in [2].  Since fire is magnetic (as described above) and is the energy of the mass [2], the strength of the material or mass lies in magnetism. The strength of the material is magnetism (a short-range force as evident by the magnetic force between two magnets), thus strength of the material lies in more magnitude of material in less volume. This is because, the material is joined by a short-range force (magnetism) as described in above statement that energy of the mass is magnetism. From previous statement, it could be seen that strength of mass/material lies in density. It is density since higher density means higher magnetic force in the mass for joining mass together.