bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparison of lactate/albumin ratio to lactate and lactate clearance for predicting outcomes in patients with septic shock admitted to intensive care unit: an observational study
Authors: Shadvar Kamran , Nader-Djalal Nader , Vahed Noushin , Sanaie Sarvin , Iranpour Afshin , Mahmoodpoor Ata , Vahedian-Azimi Amir , Samim Abbas , Rahimi-Bashar Farshid
Published: July 2022

The aim of this study was to evaluate the prognostic value of the Lactate to Albumin (L/A) ratio compared to that of lactate and lactate clearance in predicting outcomes in patients with septic shock. This was a multi-center observational study of adult patients with septic shock, who admitted to intensive care units (ICUs) at Shohada and Imam Reza Hospitals, Tabriz, Iran, between Sept 2018 and Jan 2021. The area under the curve (AUC) of receiver operating characteristic (ROC) curve and multivariate logistic regression analyses were used to explore associations of the L/A ratio, lactate and lactate clearance on the primary (mortality) and secondary outcomes [ICU length of stay (LOS), duration of mechanical ventilation (MV), need of renal replacement therapy (RRT) and duration of using vasopressors] at baseline, 6 h and 24 h of septic shock recognition. Best performing predictive value for mortality were related to lactate clearance at 24 h, L/A ratio at 6 h and lactate levels at 24 h with (AUC 0.963, 95% CI 0.918–0.987, P < 0.001), (AUC 0.917, 95% CI 0.861–0.956, P < 0.001), and (AUC 0.904, 95% CI 0.845–0.946, P < 0.001), respectively. Generally, the lactate clearance at 24 h had better prognostic performance for mortality and duration of using vasopressor. However, the L/A ratio had better prognostic performance than serum lactate and lactate clearance for RRT, ICU LOS and MV duration.
Study on emergency escape route planning under fire accidents in the Burtai coal mine
Authors: Jinzhang Jia , Fengxiao Wang
Published: July 2022

Developing an effective safety emergency plan for coal mines is crucial to prevent and reduce accidents, as well as improve the emergency response capability. This paper identifies and analyzes potential accident hazards in the Burtai coal mine through a comprehensive and practical investigation of risk factors. Based on a mathematical model of a mine fire disaster relief algorithm, the MATLAB software is used to conduct numerical simulations of the dynamic spreading process of the fire smoke. Several escape routes are determined based on the simulation results, including the main escape route at the working face of coal mining, the main escape route at the working face of tunneling, and the main escape route against the reverse wind in the main inclined shaft, the auxiliary adit, and the main air intake roadway. The results presented in this study can provide guidance for improving fire emergency escape and rescue plans of the Burtai coal mine.
Deep multi-modal learning for joint linear representation of nonlinear dynamical systems
Authors: Qian Shaodi , Chou Chun-An , Li Jr-Shin
Published: July 2022

Dynamical systems pervasively seen in most real-life applications are complex and behave by following certain evolution rules or dynamical patterns, which are linear, non-linear, or stochastic. The underlying dynamics (or evolution rule) of such complex systems, if found, can be used for understanding the system behavior, and furthermore for system prediction and control. It is common to analyze the system’s dynamics through observations in different modality approaches. For instance, to recognize patient deterioration in acute care, it usually relies on monitoring and analyzing vital signs and other observations, such as blood pressure, heart rate, respiration, and electroencephalography. These observations convey the information describing the same target system, but the dynamics is not able to be directly characterized due to high complexity of individual modality and maybe time-delay interactions among modalities. In this work, we suppose that the state behavior of a dynamical system follows an intrinsic dynamics shared among these modalities. We specifically propose a new deep auto-encoder framework using the Koopman operator theory to derive the joint linear dynamics for a target system in a space spanned by the intrinsic coordinates. The proposed method aims to reconstruct the original system states by learning the information provided among multiple modalities. Furthermore, with the derived intrinsic dynamics, our method is capable of restoring the missing observations within and across modalities, and used for predicting the future states of the system that follows the same evolution rule.
Influence of concomitant percutaneous transluminal angioplasty with percutaneous coronary intervention on clinical outcomes of stable lower extremity artery diseases
Authors: Lee Yonggu , Kim Byung-Sik , Shin Jeong-Hun , Kim Woohyeun , Kook Hyungdon , Park Hwan-Cheol , Park Minae , Park Sojeong , Lim Young-Hyo
Published: July 2022

Concomitant percutaneous transluminal angioplasty (PTA) at the time of percutaneous coronary intervention (PCI) is often performed because lower extremity artery disease (LEAD) commonly coincides with coronary artery disease. We investigated the impact of concomitant PTA on both cardiovascular and limb outcomes in the Korean National Health Insurance Service registry. Among 78,185 patients undergoing PCI, 6563 patients with stable LEAD without limb ischemia were included. After 1:5 propensity score matching was conducted, 279 patients in the PTA + PCI group and 1385 patients in the PCI group were compared. Multivariate Cox proportional hazard models showed that the risk of all-cause death was higher in the PTA + PCI group than in the PCI group, whereas the risks of myocardial infarction, repeat revascularization, stroke, cardiovascular death and bleeding events were not different between the 2 groups. In contrast, the risks of end-stage renal disease and unfavorable limb outcomes were higher in the PTA + PCI group. Mediation analyses revealed that amputation and PTA after discharge significantly mediated the association between concomitant PTA and all-cause death. Concomitant PTA was not associated with an increased risk of cardiovascular events but may increase the risk of all-cause death mediated by unfavorable renal and limb outcomes in patients with stable LEAD.
R-spondin3 is a myokine that differentiates myoblasts to type I fibres
Authors: Mita Yoshitaka , Zhu Haonan , Furuichi Yasuro , Hamaguchi Hiroki , Manabe Yasuko , Fujii Nobuharu L.
Published: July 2022

Muscle fibres are broadly categorised into types I and II; the fibre-type ratio determines the contractile and metabolic properties of skeletal muscle tissue. The maintenance of type I fibres is essential for the prevention of obesity and the treatment of muscle atrophy caused by type 2 diabetes or unloading. Some reports suggest that myokines are related to muscle fibre type determination. We thus explored whether a myokine determines whether satellite cells differentiate to type I fibres. By examining the fibre types separately, we identified R-spondin 3 (Rspo3) as a myokine of interest, a secreted protein known as an activator of Wnt signalling pathways. To examine whether Rspo3 induces type I fibres, primary myoblasts prepared from mouse soleus muscles were exposed to a differentiation medium containing the mouse recombinant Rspo3 protein. Expression of myosin heavy chain (MyHC) I, a marker of type I fibre, significantly increased in the differentiated myotubes compared with a control. The Wnt/β-catenin pathway was shown to be the dominant signalling pathway which induces Rspo3-induced MyHC I expression. These results revealed Rspo3 as a myokine that determines whether satellite cells differentiate to type I fibres.
A 19 day earth tide measurement with a MEMS gravimeter
Authors: Prasad Abhinav , Middlemiss Richard P. , Noack Andreas , Anastasiou Kristian , Bramsiepe Steven G. , Toland Karl , Utting Phoebe R. , Paul Douglas J. , Hammond Giles D.
Published: July 2022

The measurement of tiny variations in local gravity enables the observation of subterranean features. Gravimeters have historically been extremely expensive instruments, but usable gravity measurements have recently been conducted using MEMS (microelectromechanical systems) sensors. Such sensors are cheap to produce, since they rely on the same fabrication techniques used to produce mobile phone accelerometers. A significant challenge in the development of MEMS gravimeters is maintaining stability over long time periods, which is essential for long term monitoring applications. A standard way to demonstrate gravimeter stability and sensitivity is to measure the periodic elastic distortion of the Earth due to tidal forces—the Earth tides. Here, a 19 day measurement of the Earth tides, with a correlation coefficient to the theoretical signal of 0.975, has been presented. This result demonstrates that this MEMS gravimeter is capable of conducting long-term time-lapse gravimetry, a functionality essential for applications such as volcanology.
Improvement of energy conservation using blockchain-enabled cognitive wireless networks for smart cities
Authors: Rani Shalli , Babbar Himanshi , Shah Syed Hassan Ahmed , Singh Aman
Published: July 2022

In Smart Cities’ applications, Multi-node cooperative spectrum sensing (CSS) can boost spectrum sensing efficiency in cognitive wireless networks (CWN), although there is a non-linear interaction among number of nodes and sensing efficiency. Cooperative sensing by nodes with low computational cost is not favorable to improving sensing reliability and diminishes spectrum sensing energy efficiency, which poses obstacles to the regular operation of CWN. To enhance the evaluation and interpretation of nodes and resolves the difficulty of sensor selection in cognitive sensor networks for energy-efficient spectrum sensing. We examined reducing energy usage in smart cities while substantially boosting spectrum detecting accuracy. In optimizing energy effectiveness in spectrum sensing while minimizing complexity, we use the energy detection for spectrum sensing and describe the challenge of sensor selection. This article proposed the algorithm for choosing the sensing nodes while reducing the energy utilization and improving the sensing efficiency. All the information regarding nodes is saved in the fusion center (FC) through which blockchain encrypts the information of nodes ensuring that a node’s trust value conforms to its own without any ambiguity, CWN-FC pick high-performance nodes to engage in CSS. The performance evaluation and computation results shows the comparison between various algorithms with the proposed approach which achieves 10% sensing efficiency in finding the solution for identification and triggering possibilities with the value of $$\alpha = 1.5$$

α
=
1.5

and $$\gamma = 2.5$$

γ
=
2.5

with the varying number of nodes.
Evaluation of the microbial reduction efficacy and perception of use of an ozonized water spray disinfection technology
Authors: Mascarenhas Luis Alberto Brêda , dos Santos Laerte Marlon Conceição , Oliveira Fabricia Oliveira , Rodrigues Leticia de Alencar Pereira , Neves Paulo Roberto Freitas , Moreira Greta Almeida Fernandes , Santos Alex Alisson Bandeira , Lobato Gabriela Monteiro , Nascimento Carlos , Gerhardt Marcelo , Machado Bruna Aparecida Souza
Published: July 2022

The development of new approaches for the decontamination of surfaces is important to deal with the processes related to exposure to contaminated surfaces. Therefore, was evaluated the efficacy of a disinfection technology using ozonized water (0.7–0.9 ppm of O3) on the surfaces of garments and accessories of volunteers, aiming to reduce the spread of microbial pathogens in the workplace and community. A Log10 microbial reduction of 1.72–2.40 was observed between the surfaces tested. The microbial reductions remained above 60% on most surfaces, and this indicated that the disinfection technology was effective in microbial log reduction regardless of the type of transport used by the volunteers and/or their respective work activities. In association with the evaluation of efficacy, the analysis of the perception of use (approval percentage of 92.45%) was fundamental to consider this technology as an alternative for use as a protective barrier, in conjunction with other preventive measures against microbiological infections, allowing us to contribute to the availability of proven effective devices against the spread of infectious agents in the environment.
Molecular dynamics simulations explore effects of electric field orientations on spike proteins of SARS-CoV-2 virions
Authors: Kuang Zhifeng , Luginsland John , Thomas Robert J. , Dennis Patrick B. , Kelley-Loughnane Nancy , Roach William P. , Naik Rajesh R.
Published: July 2022

Emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its current worldwide spread have caused a pandemic of acute respiratory disease COVID-19. The virus can result in mild to severe, and even to fatal respiratory illness in humans, threatening human health and public safety. The spike (S) protein on the surface of viral membrane is responsible for viral entry into host cells. The discovery of methods to inactivate the entry of SARS-CoV-2 through disruption of the S protein binding to its cognate receptor on the host cell is an active research area. To explore other prevention strategies against the quick spread of the virus and its mutants, non-equilibrium molecular dynamics simulations have been employed to explore the possibility of manipulating the structure–activity of the SARS-CoV-2 spike glycoprotein by applying electric fields (EFs) in both the protein axial directions and in the direction perpendicular to the protein axis. We have found out the application of EFs perpendicular to the protein axis is most effective in denaturing the HR2 domain which plays critical role in viral-host membrane fusion. This finding suggests that varying irradiation angles may be an important consideration in developing EF based non-invasive technologies to inactivate the virus.
Home-cage behavior in the Stargazer mutant mouse
Authors: Schirmer Catharina , Abboud Mark A. , Lee Samuel C. , Bass John S. , Mazumder Arindam G. , Kamen Jessica L. , Krishnan Vaishnav
Published: July 2022

In many childhood-onset genetic epilepsies, seizures are accompanied by neurobehavioral impairments and motor disability. In the Stargazer mutant mouse, genetic disruptions of Cacng2 result in absence-like spike-wave seizures, cerebellar gait ataxia and vestibular dysfunction, which limit traditional approaches to behavioral phenotyping. Here, we combine videotracking and instrumented home-cage monitoring to resolve the neurobehavioral facets of the murine Stargazer syndrome. We find that despite their gait ataxia, stargazer mutants display horizontal hyperactivity and variable rates of repetitive circling behavior. While feeding rhythms, circadian or ultradian oscillations in activity are unchanged, mutants exhibit fragmented bouts of behaviorally defined “sleep”, atypical licking dynamics and lowered sucrose preference. Mutants also display an attenuated response to visual and auditory home-cage perturbations, together with profound reductions in voluntary wheel-running. Our results reveal that the seizures and ataxia of Stargazer mutants occur in the context of a more pervasive behavioral syndrome with elements of encephalopathy, repetitive behavior and anhedonia. These findings expand our understanding of the function of Cacng2.
The adverse impact of herbicide Roundup Ultra Plus in human spermatozoa plasma membrane is caused by its surfactant
Authors: Torres-Badia Mercedes , Solar-Malaga Soraya , Serrano Rebeca , Garcia-Marin Luis J. , Bragado M. Julia
Published: July 2022

The scarce research about the worldwide used glyphosate-based herbicide Roundup is controversial in human reproduction, especially spermatozoa. This study investigates the in vitro effect in human spermatozoa of Roundup Ultra Plus (RUP), its active ingredient glyphosate and its non-active, surfactant. Human spermatozoa were incubated (1 h, 37 °C) in presence/absence of RUP 0.01%, glyphosate, or equivalent surfactant concentration. Motility and sperm parameters were analyzed by C.A.S.A and flow cytometry, respectively. RUP significantly increases sperm plasma membrane lipid disorganization in a concentration-dependent manner while it decreases plasma membrane integrity. RUP significantly increases the death spermatozoa population after A23187-induced acrosome reaction, without affecting sperm viability, mitochondrial membrane potential, ROS content, acrosome membrane damage, phosphatidylserine exposure, A23187-induced acrosome reaction or GSK3 phosphorylation. RUP also significantly decreases motile and the a + b sperm populations. Interestingly, all sperm effects caused by RUP 0.01% are mimicked by its surfactant POEA at equivalent concentration. However, glyphosate does not affect any sperm parameter, even using 10-times higher concentration than the RUP 0.01% equivalent. RUP disturbs lipid organization and integrity of human sperm plasma membrane and reduces motility, without affecting viability or functional parameters. Importantly, RUP adverse effects in human spermatozoa are caused by the surfactant and no by glyphosate.
The relationship between serum sex hormone and cardiac echocardiographic findings in healthy men
Authors: Yeo Yohwan , Park Seung Woo , Lee Sang-Chol , Song Yun-Mi
Published: July 2022

Serum sex hormones are known to be associated with cardiovascular disease (CVD), but effects in healthy men on cardiac function have not been well quantified. The authors sought to evaluate an association of sex hormones with cardiac structure and function. Study participants were 857 Korean men without significant cardiovascular diseases participating in the Healthy Twin Study. We estimated the associations of total testosterone (TT) and sex hormone-binding globulin (SHBG) with cardiac structure and function measured by echocardiography using a linear mixed regression model with consideration of random and fixed effects of covariates. The ratio of peak early diastolic velocity of mitral inflow over peak early diastolic mitral annular velocity (E/e’) and left atrial volume index (LAVI), functional parameters reflecting left ventricle (LV) filling pressure, were inversely associated with TT even after further cross-adjustment for SHBG level. There was a positive association between LAVI and SHBG, regardless of TT adjustment. These findings suggest that serum testosterone level is positively associated with LV diastolic function independent of SHBG level.
A novel treatment and derivatization for quantification of residual aromatic diisocyanates in polyamide resins
Authors: Pastore Genny , Gabrielli Serena , Leone Ezio , Cortese Manuela , Gentili Dario , Biondi Giovanna , Marcantoni Enrico
Published: July 2022

In the scientific context, the environmental and healthy impact of polymers is more related to the residual monomer content rather than their macromolecular structure, due to the monomer capability to interact with membrane cells. For this a novel method to stabilize and quantify residual monomeric isocyanates in high thermal resistance polyamide resins (PAs) has been developed. This new analytical method resulted in an improvement concerning the quantification of residual aromatic diisocyanates in viscous polymeric matrices by using a simple and cheap technique like HPLC-VWD. Diisocyanate monomers were derivatized with dibutylamine, resulting in stable urea derivatives that were simultaneously analysed and quantified. The method was applied to solvent-based polyamide resins, used as primary electrical insulation, for avoiding additional step of solvent removing before the analysis. The quantification of residual monomers answers to the provisions imposed by European Regulation N. 1907/2006 (REACH) for polymer registration, and the necessity of an early evaluation of the occupational risk associated with the use of diisocyanates, due to their toxicity and high reactivity towards moisture.
Using HPV-meta for human papillomavirus RNA quality detection
Authors: Ure Agustin , Mukhedkar Dhananjay , Arroyo Mühr Laila Sara
Published: July 2022

In the era of cervical cancer elimination, accurate and validated pipelines to detect human papillomavirus are essential to elucidate and understand HPV association with human cancers. We aimed to provide an open-source pipeline, “HPV-meta”, to detect HPV transcripts in RNA sequencing data, including several steps to warn operators for possible viral contamination. The “HPV-meta” pipeline automatically performs several steps, starting with quality trimming, human genome filtering, HPV detection (blastx), cut-off settlement (10 reads and 690 bp coverage to make an HPV call) and finishing with fasta sequence generation for HPV positive samples. Fasta sequences can then be aligned to assess sequence diversity among HPV positive samples. All RNA sequencing files (n = 10,908) present in the cancer genome atlas (TCGA) were analyzed. “HPV-meta” identified 25 different HPV types being present in 488/10,904 specimens. Validation of results showed 99.98% agreement (10,902/10,904). Multiple alignment from fasta files warned about high sequence identity between several HPV 18 and 38 positive samples, whose contamination had previously been reported. The “HPV-meta” pipeline is a robust and validated pipeline that detects HPV in RNA sequencing data. Obtaining the fasta files enables contamination investigation, a non very rare occurrence in next generation sequencing.
Inoculation effect of Pseudomonas sp. TF716 on N2O emissions during rhizoremediation of diesel-contaminated soil
Authors: Kim Ji-Yoon , Cho Kyung-Suk
Published: July 2022

The demand for rhizoremediation technology that can minimize greenhouse gas emissions while effectively removing pollutants in order to mitigate climate change has increased. The inoculation effect of N2O-reducing Pseudomonas sp. TF716 on N2O emissions and on remediation performance during the rhizoremediation of diesel-contaminated soil planted with tall fescue (Festuca arundinacea) or maize (Zea mays) was investigated. Pseudomonas sp. TF716 was isolated from the rhizosphere soil of tall fescue. The maximum N2O reduction rate of TF716 was 18.9 mmol N2O g dry cells−1 h−1, which is superior to the rates for previously reported Pseudomonas spp. When Pseudomonas sp. TF716 was added to diesel-contaminated soil planted with tall fescue, the soil N2O-reduction potential was 2.88 times higher than that of soil with no inoculation during the initial period (0–19 d), and 1.08–1.13 times higher thereafter. However, there was no enhancement in the N2O-reduction potential for the soil planted with maize following inoculation with strain TF716. In addition, TF716 inoculation did not significantly affect diesel degradation during rhizoremediation, suggesting that the activity of those microorganisms involved in diesel degradation was unaffected by TF716 treatment. Analysis of the dynamics of the bacterial genera associated with N2O reduction showed that Pseudomonas had the highest relative abundance during the rhizoremediation of diesel-contaminated soil planted with tall fescue and treated with strain TF716. Overall, these results suggest that N2O emissions during the rhizoremediation of diesel-contaminated soil using tall fescue can be reduced with the addition of Pseudomonas sp. TF716.
A multiplex PCR assay for the identification of fruit flies (Diptera: Tephritidae) of economic importance in South Africa
Authors: Andrews Kelsey J. , Bester Rachelle , Manrakhan Aruna , Maree Hans J.
Published: July 2022

The fruit fly (Diptera: Tephritidae) species,Ceratitis capitata,Ceratitis cosyra,Ceratitis rosa,Ceratitis quilicii, andBactrocera dorsalisare of economic importance in South Africa. These agricultural pests cause extensive damage to a range of commercially produced fruit, primarily for export. These pests are of phytosanitary significance, and their presence in fruit-producing regions in South Africa has led to restrictions in export trade of fresh produce. Accurate identification of these flies, particularly at immature stages intercepted in fruit consignments originating from South Africa, is essential but remains an ongoing challenge. A rapid and accurate identification assay to differentiate these five species is needed for inspection and pest surveillance. High throughput sequencing data were generated for each of the five fruit fly species, and five sets of species-specific primers were designed for use in a multiplex PCR. Each primer set amplifies an amplicon of a different size for each species allowing for accurate identification. PCR sensitivity tests demonstrate that the limit of detection for this assay is 10 ng and 4 ng of DNA when extracted from larvae and adult specimens, respectively. The assay developed can be applied in fruit inspection and survey activities within the country and at ports of entry.
Research on shifting process control of automatic transmission
Authors: Zou Wujun , Wang Ye , Zhong Chaojie , Song Zhenchuan , Li Shenlong
Published: July 2022

The shift quality of an automatic transmission directly affects the human-perceived comfort and the durability of the automatic transmission. In general, the inconsistency caused by manufacturing errors, life-cycle changes, or other changes in hydraulic characteristics are the main reason affecting the shift quality, which should be compensated by adaptive control in the shifting process. In this paper, we first provide an in-depth analysis of the relationship between proportional solenoid current, clutch pressure, speed and torque in the shifting process control. Then we propose two efficient adaptive control strategies for the torque phase and inertia phase, respectively. Both algorithms are tested and verified on a riot utility vehicle. The experimental results indicate that the adaptive control strategies proposed in this paper can effectively compensate the engine flare and the clutch tie-up of the torque phase, and keep the inertia phase within a proper time range.
Reliability of the active drag assessment using an isotonic resisted sprint protocol in human swimming
Authors: Gonjo Tomohiro , Olstad Bjørn Harald
Published: July 2022

The purpose of the presents study was to investigate the reliability of the active drag (Da) assessment using the velocity perturbation method (VPM) with different external resisted forces. Eight male and eight female swimmers performed 25 m sprints with five isotonic loads (1–2–3–4–5 kg for females; 1–3–5–7–9 kg for males), which were repeated twice on different days. The mean velocity and semi-tethered force were computed for each condition, and the free-swimming maximum velocity was estimated with load-velocity profiling. From the obtained variables, Da at the maximum free-swimming condition was calculated using VPM. Absolute and typical errors and the intra-class correlation (ICC) were calculated to assess test–retest reliability. 95% confidence interval (95% CI) lower bound of ICC was larger than 0.75 in 3, 4 (females only) and 5 kg trials in both sexes (corresponding to 37–60 N additional resistance; all p < 0.001), which also showed small absolute and relative typical errors (≤ 2.7 N and ≤ 4.4%). In both sexes, 1 kg load trial (16–17 N additional resistance) showed the lowest reliability (95% CI of ICC; − 0.25–0.83 in males and 0.07–0.94 in females). These results suggested that a tethered force of 37–60 N should be used to assess Da using VPM.
Surgical and functional outcomes of robot-assisted versus laparoscopic partial nephrectomy with cortical renorrhaphy omission
Authors: Kubota Masashi , Yamasaki Toshinari , Murata Shiori , Abe Yohei , Tohi Yoichiro , Mine Yuta , Hagimoto Hiroki , Kokubun Hidetoshi , Suzuki Issei , Tsutsumi Naofumi , Inoue Koji , Kawakita Mutsushi
Published: July 2022

To evaluate the surgical and functional outcomes between robot-assisted (CRO-RAPN) vs. laparoscopic (CRO-LPN) methods of cortical-renorrhaphy-omitting partial nephrectomy. Between July 2012 and June 2020, patients with localized clinical T1-2 renal masses who underwent CRO-RAPN or CRO-LPN were reviewed. The outcomes of the two groups were compared using propensity-score matching. Trifecta was defined as negative surgical margin, warm ischemic time < 25 min, and absence of complications of Clavien-Dindo grade III or more until three months postoperatively. The preservation rate of the estimated glomerular filtration rate (eGFR) was evaluated at six months postoperatively. Among 291 patients (CRO-RAPN, n = 210; CRO-LPN, n = 81) included in the study, 150 matched pairs of patients were analyzed. Compared to the CRO-LPN group, the CRO-RAPN group was associated with shorter warm ischemic time (13 min vs. 20 min, P < 0.001), shorter total operation time (162 min vs. 212 min, P < 0.001), less estimated blood loss (40 mL vs. 119 mL, P = 0.002), lower incidence of overall complications (3% vs. 16%, P = 0.001), higher preservation rate of eGFR at six months postoperatively (93% vs. 89%, P = 0.003), and higher trifecta achievement rate (84% vs. 64%, P = 0.004). CRO-RAPN contributed to shorter warm ischemic time, less blood loss, fewer complications, and higher preservation of renal function, all of which allowed this technique to achieve a higher rate of trifecta compared to CRO-LPN.
Human antibodies to SARS-CoV-2 with a recurring YYDRxG motif retain binding and neutralization to variants of concern including Omicron
Authors: Liu Hejun , Kaku Chengzi I. , Song Ge , Yuan Meng , Andrabi Raiees , Burton Dennis R. , Walker Laura M. , Wilson Ian A.
Published: July 2022

Studying the antibody response to SARS-CoV-2 informs on how the human immune system can respond to antigenic variants as well as other SARS-related viruses. Here, we structurally identified a YYDRxG motif encoded by IGHD3-22 in CDR H3 that facilitates antibody targeting to a functionally conserved epitope on the SARS-CoV-2 receptor binding domain. A computational search for a YYDRxG pattern in publicly available sequences uncovered 100 such antibodies, many of which can neutralize SARS-CoV-2 variants and SARS-CoV. Thus, the YYDRxG motif represents a common convergent solution for the human humoral immune system to target sarbecoviruses including the Omicron variant. These findings suggest an epitope-targeting strategy to identify potent and broadly neutralizing antibodies for design of pan-sarbecovirus vaccines and antibody therapeutics.
Asymmetric subgenomic chromatin architecture impacts on gene expression in resynthesized and natural allopolyploid Brassica napus
Authors: Li Zeyu , Li Mengdi , Wang Jianbo
Published: July 2022

Although asymmetric subgenomic epigenetic modification and gene expression have been revealed in the successful establishment of allopolyploids, the changes in chromatin accessibility and their relationship with epigenetic modifications and gene expression are poorly understood. Here, we synthetically analyzed chromatin accessibility, four epigenetic modifications and gene expression in natural allopolyploid Brassica napus, resynthesized allopolyploid B. napus, and diploid progenitors (B. rapa and B. oleracea). “Chromatin accessibility shock” occurred in both allopolyploidization and natural evolutionary processes, and genic accessible chromatin regions (ACRs) increased after allopolyploidization. ACRs associated with H3K27me3 modifications were more accessible than those with H3K27ac or H3K4me3. Although overall chromatin accessibility may be defined by H3K27me3, the enrichment of H3K4me3 and H3K27ac and depletion of DNA methylation around transcriptional start sites up-regulated gene expression. Moreover, we found that subgenome Cn exhibited higher chromatin accessibility than An, which depended on the higher chromatin accessibility of Cn-unique genes but not homologous genes.
Biogeographic implication of temperature-induced plant cell wall lignification
Authors: Crivellaro Alan , Piermattei Alma , Dolezal Jiri , Dupree Paul , Büntgen Ulf
Published: July 2022

More than 200 years after von Humboldt’s pioneering work on the treeline, our understanding of the cold distribution limit of upright plant growth is still incomplete. Here, we use wood anatomical techniques to estimate the degree of stem cell wall lignification in 1770 plant species from six continents. Contrary to the frequent belief that small plants are less lignified, we show that cell wall lignification in ‘woody’ herbs varies considerably. Although trees and shrubs always exhibit lignified cell walls in their upright stems, small plants above the treeline may contain less lignin. Our findings suggest that extremely cold growing season temperatures can reduce the ability of plants to lignify their secondary cell walls. Corroborating experimental and observational evidence, this study proposes to revisit existing theories about the thermal distribution limit of upright plant growth and to consider biochemical and biomechanical factors for explaining the global treeline position.
Whirling interlayer fields as a source of stable topological order in moiré CrI3
Authors: Ghader Doried , Jabakhanji Bilal , Stroppa Alessandro
Published: July 2022

The moiré engineering of two-dimensional magnets opens unprecedented opportunities to design novel magnetic states with promises for spintronic device applications. The possibility of stabilizing skyrmions in these materials without chiral spin-orbit couplings or dipolar interactions is yet to be explored. Here, we investigate the formation and control of ground state topological spin textures (TSTs) in moiré $${Cr}{I}_{3}$$
C
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I

3

using stochastic Landau–Lifshitz–Gilbert simulations. We unveil the emergence of interlayer vortex and antivortex Heisenberg exchange fields, stabilizing spontaneous and field-assisted ground state TSTs with various topologies. The developed study accounts for the full bilayer spin dynamics, thermal fluctuations, and intrinsic spin-orbit couplings. By examining the effect of the Kitaev interaction and the next nearest-neighbor Dzyaloshinskii–Moriya interaction, we propose the latter as the unique spin-orbit coupling mechanism compatible with experiments on monolayer and twisted $${Cr}{I}_{3}$$
C
r

I

3

. Our findings contribute to the current knowledge about moiré skyrmionics and uncover the nature of spin-orbit coupling in $${Cr}{I}_{3}$$
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3

.
Phosphate based new organic polymer networks for efficient dye sorption and catalyst loading for chemo-selective reactivity
Authors: Dutta Shabari , Samanta Suman Kalyan , Bhattacharya Santanu
Published: July 2022

Phosphate-based porous organic polymers adsorb small cationic dyes efficiently and host gold nanoparticles for catalytic reduction of electron rich nitroaromatics.
Polymorphs and isostructural cocrystals of dexamethasone: towards the improvement of aqueous solubility
Authors: Varsa S Richu Bagya , Sanphui Palash , Chernyshev Vladimir
Published: July 2022

The crystal structures of DEX Form A and its isostructural cocrystals with catechol and resorcinol are reported with 5–6 improve aqueous solubility.
The complete mechanism of an aldol condensation in water
Authors: Perrin Charles L , Kim Jiwoo
Published: July 2022

The base-catalyzed aldol condensation between benzaldehyde and p-acetylbenzoic acid in water shows an inverse solvent kinetic isotope effect, k3,D2O/k3,H2O, of 1.33 ± 0.03.
Low-frequency Raman optical activity provides insight into the structure of chiral liquids
Authors: Michal Pavel , Kapitán Josef , Kessler Jiří , Bouř Petr
Published: July 2022

Low-frequency Raman signals of liquids are usually unstructured, but Raman optical activity provides more features. In several examples we show how the signals can be rationalized by spectral simulations and related to the liquid structure.
Surface engineering of nanoporous silicon photocathodes for enhanced photoelectrochemical hydrogen production
Authors: Jian Jing-Xin , Yao Ming-Ming , Liao Jia-Xin , Zhou Mu-Han , Chen Yi-Jing , Deng Meng-Xin , Huang Yu-Mei , Liu Chao-Ping , Tong Qing-Xiao
Published: July 2022

Comparison of the nanostructured Si photocathodes fabricated by chemical etching (c-Si), electrochemical etching (ec-Si) and photoelectrochemical etching (pec-Si) and their dramatically enhanced PEC water splitting.
Heterogenization of molecular cobalt catalysts in robust metal–organic frameworks for efficient photocatalytic CO2 reduction
Authors: Parshamoni Srinivasulu , Viravaux Cédric , Robert Marc , Mellot-Draznieks Caroline , Chen Gui , Mialane Pierre , Dolbecq Anne , Bonin Julien
Published: July 2022

Efficient, selective and recyclable heterogeneous catalysts for photocatalytic CO2 reduction to CO under visible light irradiation are readily prepared by immobilization of cobalt molecular catalysts into Zr(iv)-based MOFs.
N,S-Doped hollow carbon nanosheet-encapsulated Co9S8 nanoparticles as a highly efficient bifunctional electrocatalyst for rechargeable zinc–air batteries
Authors: Peng Yuanyuan , Zhang Fuping , Zhang Yinglin , Luo Xing , Chen Long , Shi Yulin
Published: July 2022

A “MOF on MOF” strategy was proposed for the synthesis of N,S co-doped hollow carbon nanosheets embedded with Co9S8 nanoparticles. The resulting material is a highly efficient bifunctional air electrode for Zn–air batteries.
Purple tea water extract blocks RANKL-induced osteoclastogenesis through modulation of Akt/GSK3β and Blimp1-Irf8 pathways
Authors: Zhang Yuxin , Wang Jing , Jing Chenxu , Zhou Ming-Xue , Jin Wenqi , Yan Xiuci , Hou Huanhuan , Shi Kai , Sun Wan-Chun , Sun Liwei
Published: July 2022

A number of studies demonstrated that some tea extracts exert inhibitory effects on osteoclastogenesis induced by receptor activator of nuclear factor κB ligand (RANKL).
Synergistic effect of nanosheet-array-like NiFe-LDH and reduced graphene oxide modified Ni foam for greatly enhanced oxygen evolution reaction and hydrogen evolution reaction
Authors: Wang Kun , Guo Jiawei , Zhang Hui
Published: July 2022

We have prepared highly efficient bifunctional electrocatalytic composites, NixFe1-LDH/rGO/NF (x = 3, 2, 1), with vertically staggered NiFe-LDH nanosheets grown on Ni foam uniformly modified with reduced graphene oxide through hydrothermal method.
State-of-the-art UV-assisted 3D printing via a rapid syringe-extrusion approach for photoactive vegetable oil acrylates produced in one-step synthesis
Authors: Briede Sabine , Jurinovs Maksims , Nechausov Sergey , Platnieks Oskars , Gaidukovs Sergejs
Published: July 2022

We introduce a UV-assisted syringe-extrusion based approach for vegetable oil acrylates. On-demand 3D printing can be achieved with exact and low amounts (just a few milliliters) of resin by employing a low-cost system suitable for design freedom.
Acute exercise dynamically modulates the hepatic mitochondrial proteome
Authors: McCoin Colin S. , Franczak Edziu , Washburn Michael P. , Sardiu Mihaela E. , Thyfault John P.
Published: July 2022

Mitochondrial proteomics analysis reveals acute exercise rapidly elicits hepatic proteome remodeling, including pathways related to metabolism, oxidative stress, inflammation, and post-translational modifications.
Flexible and transparent electrodes imprinted from Au nanowires: stability and ageing
Authors: Engel Lukas F. , González-García Lola , Kraus Tobias
Published: July 2022

Plasma sintering lines imprinted from oleylamine-capped Au nanowires yields conductors with porous Au shell and hybrid core. Thick conductors retain more organics and age faster than thin ones. PEDOT:PSS coatings stabilize the shell and stop ageing.
Vertically oriented SnS2 on MoS2 nanosheets for high-photoresponsivity and fast-response self-powered photoelectrochemical photodetectors
Authors: Liu Yuqi , Lu Chunhui , Luo Mingwei , Han Taotao , Ge Yanqing , Dong Wen , Xue Xinyi , Zhou Yixuan , Xu Xinlong
Published: July 2022

Van der Waals epitaxial growth of a SnS2/MoS2 heterostructure with trap-like vertically oriented nanostructures was designed and utilized for high-photoresponsivity and fast-response self-powered photoelectrochemical photodetectors.
Two-dimensionalcovalent triazine frameworks as superior nanocarriers for the delivery of thioguanine anti-cancer drugs: a periodic DFT study
Authors: Rahimi Rezvan , Solimannejad Mohammad , Soleimannejad Mostafa
Published: July 2022

This work aims to introduce a superior nanocarrier for thioguanine (TG) anti-cancer drug delivery, drug release, and cancer therapy through computational chemistry.
A cysteine-induced one-pot synthesis of Au nanoparticle chains with tuneable NIR absorption and application in photothermal-chemo cancer therapy
Authors: Gao Pengcheng , Wei Yingying , Xu Qianrui , Jiang Yong
Published: July 2022

A one-pot synthesis of AuNCs induced by l-cys and fabrication of AuNCs@mSiO2@DOX and its photothermal-chemo cancer therapy behavior.
N, P co-doping triggered phase transition of MoS2 with enlarged interlayer spacing for efficient hydrogen evolution
Authors: Feng Ailing , Ding Shijiu , Liu Peitao , Zu Yanqing , Han Fengbo , Li Xiaodong , Liu Liang , Chen Yanan
Published: July 2022

Molybdenum disulfide (MoS2)-based transition-metal chalcogenides are considered to be cost-efficient, environmentally-friendly, and stable materials in the application of electrocatalytic hydrogen production.
Photoinduced magnetic hysteresis in a cyanide-bridged two-dimensional [Mn2W] coordination polymer
Authors: Zhu Hai-Lang , Meng Yin-Shan , Hu Ji-Xiang , Oshio Hiroki , Liu Tao
Published: July 2022

A 2D coordination polymer [Mn2W] underwent photoinduced singlet (S= 0) to triplet (S= 1) transition on the WIVions, resulting in magnetic ordering with a transition temperature of 24 K and a hysteresis loop up to 15 K.
Polyhedron ZIF-67 nanoparticles deposited on a D-shape fibre for stable soliton operation in an ultrashort fibre laser
Authors: Xu Mingjie , Chu Hongwei , Hu Yutao , Pan Han , Pan Zhongben , Zhao Shengzhi , Li Dechun
Published: July 2022

In this study, we report the nonlinear optical properties of the polyhedron zeolitic imidazolate framework-67 (ZIF-67) deposited on a D-shape fibre.
Two multifunctional stimuli-responsive materials with room-temperature phosphorescence and their application in multiple dynamic encryption
Authors: Yang Dong-Dong , Meng Fan-Qi , Zheng Han-Wen , Shi Yong-Sheng , Xiao Tong , Jin Bo , Liang Qiong-Fang , Zheng Xiang-Jun , Tan Hong-Wei
Published: July 2022

A new strategy for the synthesis of multifunctional stimuli-responsive room-temperature phosphorescent materials and their application in multiple dynamic encryption was reported.
Kinetics of shear banding flow formation in linear and branched wormlike micelles
Authors: Rassolov Peter , Scigliani Alfredo , Mohammadigoushki Hadi
Published: July 2022

We investigate the flow evolution of a linear and a branched wormlike micellar solution with matched rheology in a Taylor–Couette (TC) cell using a combination of particle-tracking velocimetry, birefringence, and turbidity measurements.
NH-rich red poly(heptazine imide) nanoparticles with simultaneously promoted exciton dissociation and activated n → π* electronic transition for boosted photocatalytic H2 generation
Authors: Zhao Zhengliang , Shu Zhu , Zhou Jun , Ye Lina , Li Tiantian , Wang Wenbin , Xu Lina
Published: July 2022

Red PHI nanoparticles synthesized by calcining melamine with KCl/KSCN exhibit activated n→π* electronic transition and shortened charge transfer distance, resulting in extended visible-light response range and promoted exciton dissociation efficiency.
Boosting of overall water splitting activity by regulating the electron distribution over the active sites of Ce doped NiCo–LDH and atomic level understanding of the catalyst by DFT study
Authors: Dhandapani Hariharan N. , Mahendiran D. , Karmakar Arun , Devi Pandiarajan , Nagappan Sreenivasan , Madhu Ragunath , Bera Krishnendu , Murugan Palanichamy , Babu B. Ramesh , Kundu Subrata
Published: July 2022

Ce3+ ion doped NiCoLDHs have applied as a promising electrocatalysts for water splitting. 9.715 times high TOF has observed as a result of Ce doping. DFT study shows that Co-3d states are highly responsible for catalytic activity of the catalyst.
Single-crystalline-like indium tin oxide thin films prepared by plasma enhanced atomic layer deposition
Authors: Hsu Chia-Hsun , Zhang Zhi-Xuan , Shi Chun-Yan , Huang Pao-Hsun , Wu Wan-Yu , Wuu Dong-Sing , Gao Peng , Huang Chien-Jung , Lien Shui-Yang , Zhu Wen-Zhang
Published: July 2022

Plasma enhanced atomic layer deposited indium tin oxide films using InCp, TDMASn and O2 plasma as metal and oxygen precursors exhibit a single-crystalline-like structure, high carrier mobility and low resistivity.
Mechanical-load and temperature-engendered degradation of α-CsPbI3: reactive molecular dynamics simulation
Authors: Kumar Sunil , Mishra Trilochan , Sahu Ranjan K.
Published: July 2022

The structural stability of CsPbI3 has been studied using reactive molecular dynamics simulation under mechanical-load and temperature induced stress.
Molecular engineering guided dielectric resonance tuning in derived carbon materials
Authors: Shi Jiaoyan , Zhuang Qiu , Wu Lipeng , Guo Ronghui , Huang Ling , Li Weijin , Wu Fan , Xie Aming
Published: July 2022

Dielectric resonance tuning could improve the electromagnetic wave absorption (EMA) properties of materials; however, current strategies for dielectric resonance tuning are scarcely reported.
Enhanced CACIS configuration for direction of arrival estimation
Authors: Zhang Yule , Hu Guoping , zhang Fei , Zhou Hao
Published: July 2022

In this letter, an enhanced coprime array with compressed inter‐element spacing is designed for direction of arrival estimation. First, we analyse and conclude that the 0th sensor of coprime array with compressed inter‐element spacing is redundant for the consecutive lags, thus it is rearranged to the negative part to obtain enhanced coprime array with compressed inter‐element spacing. Then, on the basis of discussing the effect of the shift sensor on the difference co‐array, the number of unique lags and the range of consecutive lags are derived. Theoretical properties show that the closed‐form expressions of coprime array with compressed inter‐element spacing and enhanced coprime array with compressed inter‐element spacing are similar, while more difference lags can be generated from the latter. Moreover, larger inter‐element spacing can slightly alleviate the mutual coupling. Numerical examples verify the advantages of enhanced coprime array with compressed inter‐element spacing in direction of arrival estimation over coprime array with compressed inter‐element spacing configuration and other coprime arrays.
Latitudinal dynamics of co-orbital charged dust in the heliosphere
Authors: Reiter Stefanie , Lhotka Christoph
Published: July 2022

In recent years, observations have found evidence for dust at higher ecliptic latitudes. Different possible explanations for these signatures have been proposed, most commonly assuming that they originate from collisions of young asteroid families. In the present work, we investigate the influence of the interplanetary magnetic field causing strong latitudinal oscillations that may affect the creation and evolution of dust at these latitudes. Using numerical simulations of a charged dust particle affected by the Lorentz force, we analyse the effect of a simplified magnetic field model specifically on the long-term evolution of the orbital plane of the dust grain. Additionally, we demonstrate the significant agreement with the results of the semi-analytical secular-resonant model we have developed for charged particles in co-orbital motion with a planet. We have found that the interplanetary magnetic field determines the three-dimensional distribution of micron-sized dust grains, causing large excursions of the orbital inclination that distribute the particles to high ecliptic latitudes. The strength of these oscillations depends in particular on the particle size and on the distance to the Sun. Farther outwards in the Solar System, the particle amplitudes are larger.