bluuebunny/crossref_metadata_2025 huggingface dataset:
Violent Nonlinear Collapse in the Interior of Charged Hairy Black Holes
Authors: Van de Moortel Maxime
Published: September 2024

We construct a new one-parameter family, indexed by $$\epsilon $$
ϵ
, of two-ended, spatially-homogeneous black hole interiors solving the Einstein–Maxwell–Klein–Gordon equations with a (possibly zero) cosmological constant $$\Lambda $$
Λ
and bifurcating off a Reissner–Nordström-(dS/AdS) interior ($$\epsilon =0$$

ϵ
=
0

). For all small $$\epsilon \ne 0$$

ϵ
≠
0

, we prove that, although the black hole is charged, its terminal boundary is an everywhere-spacelike Kasner singularity foliated by spheres of zero radius r. Moreover, smaller perturbations (i.e. smaller $$|\epsilon |$$

|
ϵ
|

) are more singular than larger ones, in the sense that the Hawking mass and the curvature blow up following a power law of the form $$r^{-O(\epsilon ^{-2})}$$

r

-
O
(

ϵ

-
2

)

at the singularity $$\{r=0\}$$

{
r
=
0
}

. This unusual property originates from a dynamical phenomenon—violent nonlinear collapse—caused by the almost formation of a Cauchy horizon to the past of the spacelike singularity $$\{r=0\}$$

{
r
=
0
}

. This phenomenon was previously described numerically in the physics literature and referred to as “the collapse of the Einstein–Rosen bridge”. While we cover all values of $$\Lambda \in \mathbb {R}$$

Λ
∈
R

, the case $$\Lambda <0$$

Λ
<
0

is of particular significance to the AdS/CFT correspondence. Our result can also be viewed in general as a first step towards the understanding of the interior of hairy black holes.
Gh-convergence of CAT(0)-spaces: stability of the Euclidean factor
Authors: Cavallucci Nicola
Published: September 2024

We prove that if a sequence of geodesically complete CAT(0)-spaces

$$X_j$$

X
j

with uniformly cocompact discrete groups of isometries converges in the Gromov-Hausdorff sense to

$$X_\infty $$

X
∞

, then the dimension of the maximal Euclidean factor splitted off by

$$X_\infty $$

X
∞

and

$$X_j$$

X
j

is the same, for j big enough. In other words, no additional Euclidean factors can appear in the limit.
Speech-evoked cortical activities and speech recognition in adult cochlear implant listeners: a review of functional near-infrared spectroscopy studies
Authors: Farrar Reed , Ashjaei Samin , Arjmandi Meisam K.
Published: September 2024

Cochlear implants (CIs) are the most successful neural prostheses, enabling individuals with severe to profound hearing loss to access sounds and understand speech. While CI has demonstrated success, speech perception outcomes vary largely among CI listeners, with significantly reduced performance in noise. This review paper summarizes prior findings on speech-evoked cortical activities in adult CI listeners using functional near-infrared spectroscopy (fNIRS) to understand (a) speech-evoked cortical processing in CI listeners compared to normal-hearing (NH) individuals, (b) the relationship between these activities and behavioral speech recognition scores, (c) the extent to which current fNIRS-measured speech-evoked cortical activities in CI listeners account for their differences in speech perception, and (d) challenges in using fNIRS for CI research. Compared to NH listeners, CI listeners had diminished speech-evoked activation in the middle temporal gyrus (MTG) and in the superior temporal gyrus (STG), except one study reporting an opposite pattern for STG. NH listeners exhibited higher inferior frontal gyrus (IFG) activity when listening to CI-simulated speech compared to natural speech. Among CI listeners, higher speech recognition scores correlated with lower speech-evoked activation in the STG, higher activation in the left IFG and left fusiform gyrus, with mixed findings in the MTG. fNIRS shows promise for enhancing our understanding of cortical processing of speech in CI listeners, though findings are mixed. Challenges include test-retest reliability, managing noise, replicating natural conditions, optimizing montage design, and standardizing methods to establish a strong predictive relationship between fNIRS-based cortical activities and speech perception in CI listeners.
CAR-T cells for the treatment of pediatric chronic myeloid leukemia in repeatedly relapsed lymphoid blast phase
Authors: Kramp Laura-Jane , Heydrich-Karsten Christiane , Sembill Stephanie , Karow Axel , Lion Thomas , Chitadze Guranda , Suttorp Meinolf , Cario Gunnar , Metzler Markus
Published: September 2024

Chronic myeloid leukemia presenting de novo in the blast phase (CML-BP) is a rare diagnosis among pediatric malignancies. We report on a 16-year-old male who presented with CML-BP lymphoid at diagnosis. He was treated with shortened acute lymphoblastic leukemia induction plus the tyrosine kinase inhibitor (TKI) imatinib followed by dasatinib. After achieving molecular remission (MR), hematopoietic stem cell transplantation (HSCT) was performed early after diagnosis. Despite prophylactic dasatinib, he relapsed 3 months later with the kinase domain mutation T315I. Multiple therapeutic approaches including ponatinib, blinatumomab, a 2nd HSCT from a different donor, donor lymphocyte infusions, and high-dose asciminib all resulted in subsequent relapse. Another molecular response was achieved by combining ponatinib plus asciminib with chemotherapy. In this situation, CD19-directed CAR-T cells (Kymriah®) were administered for compassionate use and tolerated without adverse events. Compared to all prior therapies, CAR T-cells maintained remission. After 12 months of follow-up, complete B-cell aplasia and low numbers of CAR-T cells are detectable in the peripheral blood, potentially mediating long-term disease control.
TDP-43 regulates LC3ylation in neural tissue through ATG4B cryptic splicing inhibition
Authors: Torres Pascual , Rico-Rios Santiago , Ceron-Codorniu Miriam , Santacreu-Vilaseca Marta , Seoane-Miraz David , Jad Yahya , Ayala Victòria , Mariño Guillermo , Beltran Maria , Miralles Maria P. , Andrés-Benito Pol , Fernandez-Irigoyen Joaquin , Santamaria Enrique , López-Otín Carlos , Soler Rosa M. , Povedano Monica , Ferrer Isidro , Pamplona Reinald , Wood Matthew J. A. , Varela Miguel A. , Portero-Otin Manuel
Published: September 2024

Amyotrophic lateral sclerosis (ALS) is an adult-onset motor neuron disease with a mean survival time of three years. The 97% of the cases have TDP-43 nuclear depletion and cytoplasmic aggregation in motor neurons. TDP-43 prevents non-conserved cryptic exon splicing in certain genes, maintaining transcript stability, including ATG4B, which is crucial for autophagosome maturation and Microtubule-associated proteins 1A/1B light chain 3B (LC3B) homeostasis. In ALS mice (G93A), Atg4b depletion worsens survival rates and autophagy function. For the first time, we observed an elevation of LC3ylation in the CNS of both ALS patients and atg4b−/− mouse spinal cords. Furthermore, LC3ylation modulates the distribution of ATG3 across membrane compartments. Antisense oligonucleotides (ASOs) targeting cryptic exon restore ATG4B mRNA in TARDBP knockdown cells. We further developed multi-target ASOs targeting TDP-43 binding sequences for a broader effect. Importantly, our ASO based in peptide-PMO conjugates show brain distribution post-IV administration, offering a non-invasive ASO-based treatment avenue for neurodegenerative diseases.
Phosphate level changes in oral cancer patients – recognizing the risk for refeeding syndrome
Authors: Silén Suvi , Wilkman Erika , Haukilehto Emilia , Keinänen Arvi , Mäkitie Antti , Snäll Johanna
Published: September 2024

Purpose

Patients with oral squamous cell carcinoma (OSCC) often have difficulties in obtaining sufficient nutrition and may develop refeeding syndrome (RFS) during hospitalization. RFS may be fatal if not treated properly. This study clarified changes in perioperative phosphate levels and occurrence of RFS symptoms in OSCC patients to identify clinically notable predisposing factors for RFS in this specific patient population.

Methods

A retrospective analysis included primary OSCC patients with microvascular free flap reconstruction. Patients with treatment for additional malignancy, hypoparathyroidism, and missing values of preoperative and/or postoperative plasma phosphate (P-Pi) concentration were excluded. The outcome variable was severe postoperative hypophosphataemia (mmol/l) during the postoperative period (P-Pi < 0.50 mmol/l). Predictor variables were age, sex, smoking, heavy alcohol use, diabetes, body mass index (BMI), weight, height, tumour site, tumour size, tracheostomy, nutritional route, and preoperative P-Pi concentration.

Results

Of the 189 patients with primary OSCC, 21 (11%) developed severe hypophosphataemia. Of these patients, 17 (81%) developed RFS symptoms. Higher age (p = 0.01), lower patient height (p = 0.05), and no current smoking (p = 0.04) were significantly associated with postoperative hypophosphataemia. In multivariable regression analyses, higher age (OR 1.06 per year) and age over 70 years (OR 3.77) were independently associated with development of severe hypophosphataemia.

Conclusion

Restoration of nutritional balance and close follow-up of electrolyte balance in the perioperative phase are necessary to prevent RFS, especially in patients with oral cancer requiring extensive reconstructions. Special attention should be focused on elderly patients since they are prone to this unnoticeable but potentially life-threatening electrolyte disturbance.
Muscle endurance, neuromuscular fatigability, and cognitive control during prolonged dual-task in people with chronic obstructive pulmonary disease: a case–control study
Authors: Chatain Cyril , Vallier Jean-Marc , Paleiron Nicolas , Cucchietti Waltz Fanny , Ramdani Sofiane , Gruet Mathieu
Published: September 2024

Purpose

Recent studies suggest that, compared to healthy individuals, people with chronic obstructive pulmonary disease (pwCOPD) present a reduced capacity to perform cognitive-motor dual-task (CMDT). However, these studies were focused on short-duration CMDT offering limited insight to prolonged CMDT inducing fatigue, which can be encountered in daily life. The present study aimed to explore the effect of adding a cognitive task during repeated muscle contractions on muscle endurance, neuromuscular fatigability, and cognitive control in pwCOPD compared to healthy participants.

Methods

Thirteen pwCOPD and thirteen age- and sex-matched healthy participants performed submaximal isometric contractions of the knee extensors until exhaustion in two experimental sessions: (1) without cognitive task and (2) with a concurrent working memory task (i.e., 1-back task). Neuromuscular fatigability (as well as central and peripheral components measured by peripheral magnetic stimulation), cognitive performance, and perceived muscle fatigue were assessed throughout the fatiguing tasks.

Results

Independently to the experimental condition, pwCOPD exhibited lower muscle endurance compared to healthy participants (p = 0.039), mainly explained by earlier peripheral fatigue and faster attainment of higher perceived muscle fatigue (p < 0.05). However, neither effect of cognitive task (p = 0.223) nor interaction effect (group × condition; p = 0.136) was revealed for muscle endurance. Interestingly, cognitive control was significantly reduced only in pwCOPD at the end of CMDT (p < 0.015), suggesting greater difficulty for patients with dual tasking under fatigue.

Conclusion

These findings provide novel insights into how and why fatigue develops in COPD in dual-task context, offering a rationale for including such tasks in rehabilitation programs.
How far can we go? A 20-year meta-analysis of dental implant survival rates
Authors: Kupka Johannes Raphael , König Jochem , Al-Nawas Bilal , Sagheb Keyvan , Schiegnitz Eik
Published: September 2024

Objective

This meta-analysis aims to investigate the long-term survival rates of dental implants over a 20-year period, providing a practical guide for clinicians while identifying potential areas for future research.

Materials and methods

Data were sourced from recent publications, focusing exclusively on screw-shaped titanium implants with a rough surface. Both retrospective and prospective studies were included to ensure an adequate sample size. A systematic electronic literature search was conducted in the databases: MEDLINE (PubMed), Cochrane, and Web of Science. The risk of bias for all studies was analyzed using a tool by Hoy et al.

Results

Three prospective studies (n = 237 implants) revealed a mean implant survival rate of 92% (95% CI: 82% to 97%), decreasing to 78% (95% CI: 74%-82%) after imputation (n = 422 implants). A total of five retrospective studies (n = 1440 implants) showed a survival rate of 88% (95% CI: 78%-94%). Implant failure causes were multifactorial.

Conclusion

This review consolidates 20-year dental implant survival data, reflecting a remarkable 4 out of 5 implants success rate. It emphasizes the need for long-term follow-up care, addressing multifactorial implant failure. Prioritizing quality standards is crucial to prevent overestimating treatment effectiveness due to potential statistical errors. While dental implantology boasts reliable therapies, there is still room for improvement, and additional high-quality studies are needed, particularly to evaluate implant success.

Clinical relevance

Never before have the implant survival over 20 years been systematically analyzed in a meta-analysis. Although a long-term survival can be expected, follow-up is essential and shouldn't end after insertion or even after 10 years.
Intraoperative use of virtual reality decreases anxiety during surgery under local anaesthesia in the head and neck region
Authors: Tippelt L. , Sommer F. , Schmid S. , Theodoraki M. N. , Laban S. , Emmanuel B. , Coburger J. , Hoffmann T. K. , Schuler P. J.
Published: September 2024

The availability of virtual reality (VR) in the medical field has been rapidly increasing in the past years. Here we investigate to which extent the VR headset can lead to a reduction in anxiety and pain in patients during surgical procedures under local anesthesia in the head and neck region. Patients were divided into a study group (N = 67) and a control group (N = 28). The study group used a VR headset during surgical procedures in the head and neck region under local anaesthesia. Before and after surgery, the influence of the VR headset on perioperative anxiety was assessed using the State-Trait-Anxiety-Inventory (STAI) in both groups. The use of a VR headset leads to a significant reduction in perioperative anxiety. The anxiety scores measured by means and ranks of the STAI were significantly decreased (p = .002). However, 14/67 (20.9%) of the patients wearing the VR headset also reported higher intraoperative tension. No technical complications occurred intraoperatively. 48/67 (71.7%) of the patients would be less apprehensive about a future operation when using a VR headset and 58/67 (86.6%) would further recommend the use of a VR headset to other patients. In addition to a trusting surgeon-patient relationship and the use of sufficient local anaesthesia, the use of a VR headset as a method of distraction can further reduce the intraoperative anxiety of patients.
Prognostic analysis of Pneumocystis jirovecii pneumonia in patients with systemic vasculitides: a retrospective cohort study
Authors: Chen Ruxuan , Shi Yujie , Sun Hongli , Xu Kai , Li Zhiyi , Wang Mengqi , Shao Chi , Huang Hui
Published: September 2024

Objectives

Pneumocystis jirovecii pneumonia (PJP) is a serious complication of autoimmune and inflammatory diseases. This study aimed to describe the characteristics of PJP in patients with various systemic vasculitides and explore potential prognostic factors.

Method

Data on 62 enrolled PJP patients with systemic vasculitis were analyzed. Patients were stratified based on the outcomes. Prognostic factors were investigated using Cox-regression models. Characteristics of patients with and without interstitial lung disease (ILD) were compared.

Results

Among 62 vasculitis-PJP patients, 48 had anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV), with microscopic polyangiitis (MPA) being the most common subtype (28 patients). MPA (HR 4.33, p = 0.001), concomitant aspergillosis (HR 2.68, p = 0.019), and higher D-dimer at PJP diagnosis (HR 1.07, p = 0.004) were independent adverse prognostic factors for overall survival. Stable disease activity of vasculitis was an independent favorable prognostic factor (HR 0.28, p = 0.027). Patients with MPA were older than non-MPA patients (median age: 69 vs. 58 years, p = 0.001); both ILD and fibrotic ILD were more prevalent in MPA patients (ILD: 78.6% vs. 35.3%, p = 0.001; fibrotic ILD: 57.1% vs. 11.8%, p < 0.001). At the diagnosis of PJP, patients with preexisting ILD had higher counts of white cells, lymphocytes, and neutrophils, as well as higher levels of immunoglobulin (Ig) G and IgA, than patients without preexisting ILD.

Conclusions

MPA was associated with a higher risk of death in patients with vasculitis-PJP, possibly due to a higher prevalence of ILD. In clinical practice, we should pay more attention to the prophylaxis and management of PJP in patients with systemic vasculitis-associated ILD and/or MPA.

Key Points• Data from this study showed that MPA was the most common subtype of vasculitis among vasculitis-PJP patients.• Compared with non-MPA patients in this study, patients with MPA were older, had more ILD and fibrotic ILD, and had a poorer prognosis.• In clinical practice, we should pay more attention to the prophylaxis and management of PJP in patients with systemic vasculitis-associated ILD and/or MPA.
Addressing the climate adaptation tracking gap: an assessment method and its application to the Caribbean region
Authors: Laurent Camille , Duvat Virginie K. E.
Published: September 2024

This article addresses the climate adaptation tracking gap. Indeed, we still ignore the intensity, nature, spatial distribution, effectiveness, and recent evolution of adaptation efforts at the national, regional, and global scales. We propose a web-based replicable assessment method using key variables to document adaptation efforts: country/territory, location, goal, implementation date, type of action, holder, funding source. Applying it to the Caribbean region, we analyzed 100 coastal adaptation actions. This studies the method while also highlighting the difficulties faced to track adaptation. We found that coastal adaptation efforts are substantial and increasing in the Caribbean, revealing the use of diversified adaptation actions; prevalence of hard protection (51%); increase use of Nature-based Solutions (22%); limited use of retreat (6%); and accommodation (2%). Combined actions (17%) increased over time, due to the failure of single actions and need to find tradeoffs between human asset protection encouraging hard protection and the maintenance of attractive tourist beaches encouraging beach nourishment. Puerto Rico and Trinidad and Tobago fall under the engineering-based “one-size-fits-all” adaptation model, whereas Jamaica and Barbados experiment diversified options and combinations of options. Jamaica, Puerto Rico, Trinidad and Tobago, and Barbados are particularly active in taking adaptation action, while most dependent islands and sub-national island jurisdictions have no adaptation action reported. Considering the advantages and limitations of a web-based method compared to a field-based approach, we recommend the combined use of these two complementary approaches to support adaptation tracking and help structuring communities of practice to the benefits of decision-makers and practitioners and scholars.
Local excision vs. proctectomy in patients with ypT0–1 rectal cancer following neoadjuvant therapy: a propensity score matched analysis of the National Cancer Database
Authors: Horesh N. , Emile S. H. , Freund M. R. , Garoufalia Z. , Gefen R. , Nagarajan A. , Wexner S. D.
Published: September 2024

Background

We aimed to evaluate outcomes of organ preservation by local excision (LE) compared to proctectomy following neoadjuvant therapy for rectal cancer.

Methods

This retrospective observational study using the National Cancer Database (NCDB) included patients with locally advanced non-metastatic rectal cancer (ypT0–1 tumors) treated with neoadjuvant therapy between 2004 and 2019. Outcomes of patients who underwent LE or proctectomy were compared. 1:1 propensity score matching including patient demographics, clinical and therapeutic factors was used to minimize selection bias. Main outcome was overall survival (OS).

Results

11,256 of 318,548 patients were included, 526 (4.6%) of whom underwent LE. After matching, mean 5-year OS was similar between the groups (54.1 vs. 54.2 months; p = 0.881). Positive resection margins (1.2% vs. 0.6%; p = 0.45), pathologic T stage (p = 0.07), 30-day mortality (0.6% vs. 0.6%; p = 1), and 90-day mortality (1.5% vs. 1.2%; p = 0.75) were comparable between the groups. Length of stay (1 vs. 6 days; p < 0.001) and 30-day readmission rate (5.3% vs. 10.3%; p = 0.02) were lower in LE patients. Multivariate analysis of predictors of OS demonstrated male sex (HR 1.38, 95% CI 1.08–1.77; p = 0.009), higher Charlson score (HR 1.52, 95% CI 1.29–1.79; p < 0.001), poorly differentiated carcinoma (HR 1.61, 95% CI 1.08–2.39; p = 0.02), mucinous carcinoma (HR 3.53, 95% CI 1.72–7.24; p < 0.001), and pathological T1 (HR 1.45, 95% CI 1.14–1.84; p = 0.002) were independent predictors of increased mortality. LE did not correlate with worse OS (HR 0.91, 95% CI 0.42–1.97; p = 0.82).

Conclusion

Our findings show no overall significant survival difference between LE and total mesorectal excision, including ypT1 tumors. Moreover, patients with poorly differentiated or mucinous adenocarcinomas generally had poorer outcomes, regardless of surgical method.
Inhibition of ADAM17 attenuates high glucose-induced angiogenesis and inflammation in endothelial cells partly through down-regulation of GRO-α/CXCR2 expression: implications in peritoneal dialysis
Authors: Jiang Na , Feng Hao , Xie Weizhen , Gu Leyi , Fang Wei , Ding Tingting , Yuan Jiangzi
Published: September 2024

Background

Angiogenesis and inflammation are key events leading to peritoneal morphologic alteration and ultrafiltration failure in patients undergoing peritoneal dialysis (PD). The current study aims to explore the role of ADAM17 in the angiogenetic and inflammatory responses of endothelial cells.

Methods

Human umbilical vein endothelial cells (HUVECs) were cultured and treated with a high glucose-containing medium. In parallel experiments, the expression of ADAM17 in HUVECs was inhibited by SiRNA interference. The mRNA and protein expression of ADAM17, GRO-α and CXCR2 were assessed by qPCR and Western blotting, respectively. The concentrations of GRO-α, VEGF, IL-6 and TNF-α in the cellular supernatants were determined by ELISA. Tube formation and migration of HUVECs were evaluated by Matrigel and transwell migration apparatus.

Results

High glucose increased the expression of ADAM17, CXCR2 and GRO-α in cultured HUVECs. RNA silencing of ADAM17 abolished high glucose-mediated increase of GRO-α and CXCR2, which were accompanied by reduced secretion of VEGF, IL-6, TNF-α, as well as tube formation and cell migration in HUVECs.

Conclusions

Inhibition of ADAM17 ameliorates high glucose-induced angiogenic and inflammatory responses in endothelial cells partly through down-regulation of GRO-α/CXCR2 expression.
Aggressive behavior as a predictor of home range size: findings from both range-restricted and widespread Darwin’s finch species
Authors: García-Loor Jefferson , Gallego-Abenza Mario , Katsis Andrew C. , Puehringer-Sturmayr Verena , Colombelli-Négrel Diane , Akçay Çağlar , Kleindorfer Sonia
Published: September 2024

Information about an animal’s home range (the geographical area in which it accesses resources for survival and reproduction) is vital broadly for understanding animal behavior and specifically for developing conservation management plans. Although personality traits—consistent individual differences in behavior across time and contexts—may affect an animal’s home range size, we still lack a breadth of empirical studies across systems to fully appreciate this influence. Here, we tested the relationship between behavioral responses and home range size in two Darwin’s finch species on Floreana Island: the critically endangered and range-restricted Medium Tree Finch (Camarhynchus pauper) and the common and widespread Small Ground Finch (Geospiza fuliginosa). Using a combination of rapid-assessment assays during both short-term captivity and in the field, we measured exploration and aggressiveness in males from both species. We then used radio telemetry to measure each bird’s home range size over a week-long period. We predicted that (1) fast-exploring individuals would have larger home ranges, and (2) more aggressive individuals would have smaller home ranges. We found that Medium Tree Finches had smaller home ranges than Small Ground Finches, that exploratory behavior was positively correlated with home range size only in Small Ground Finches, and that, in both species, individuals’ aggressiveness was negatively correlated with home range size, whereby the more aggressive individuals occupied smaller home ranges. We conclude that behavioral responses that align with major personality traits can predict home range size, which may provide an important tool for the conservation and management of endangered species when, for example, selecting individuals with different personality profiles for reintroduction.
Rock glacier springs: cool habitats for species on the edge
Authors: Martini Jan , Brighenti Stefano , Vanek Magdalena , Schwingshackl Thea , Vallefuoco Francesca , Scotti Alberto , Lencioni Valeria , Bottarin Roberta
Published: September 2024

Under climate change, glacier recession and the loss of cold habitats are major threats to aquatic biodiversity. In mountain areas, streams originating from rock glaciers, called “icy seeps”, may represent climate refugia for cold-adapted organisms, given the major persistence of cold waters from these landforms even in unfavourable climates. During late summer 2021, we investigated discharge, turbidity, water chemistry (major ions and trace elements), stable water isotopes (δ18O, δ2H), and macroinvertebrate communities of five rock glacier springs (icy seeps), five glacier springs (glacier springs) and five non-glacial springs (spring brooks) in catchments of the Eastern Italian Alps. In icy seeps, meltwater contribution to runoff (estimated with end-member mixing models) was intermediate between those of the other two spring types. Icy seeps had very cold waters (< 1.5 °C) that were enriched in trace elements, like glacier springs, whereas discharge and turbidity were low, like in spring brooks. Community composition, diversity, and species associations of icy seeps were strongly related to a gradient of chemical harshness (built using trace element concentrations), with less contaminated springs hosting communities like those dwelling in spring brooks. Like glacier springs, those icy seeps with the harshest water chemistry (particularly because of Ni concentrations) and higher meltwater contribution hosted species (e.g., Diamesa steinboecki) that are currently in decline due to glacier loss. This suggests a high conservation value for icy seeps. The protection of these habitats, nowadays overlooked, will be fundamental under the progressive warming and dry-out risk of alpine springs.
Flow Field Characteristics at the Spanwise Edge of a Vegetative Canopy Model
Authors: Winiarska Ewelina , Liberzon Dan , van Hout René
Published: September 2024

This study investigates the complex flow field across a spanwise vegetative model canopy edge focusing on turbulent transport processes. Utilizing stereoscopic particle image velocimetry, the three velocity components were measured in wall-parallel planes at various elevations within canopy across the spanwise canopy edge. Conventional ensemble averaged results were contrasted with those obtained by conditionally averaged flow properties across instantaneous internal interfaces in the flow to understand their contribution to the ensemble average. The conditional average captured the strong gradients in mean velocities, Reynolds stresses, vorticity, swirling strength, and turbulent kinetic energy production across the dynamically changing instantaneous interface. In contrast, the conventional ensemble average smeared out the strong gradients. Small magnitudes of advective terms in the turbulent kinetic energy transport equation suggested weak secondary transverse flows in the present model canopy. The turbulent flow structure across the spanwise canopy edge was further investigated using Quadrant-Hole analysis for both averaging approaches. Conventional ensemble averaged results indicated a shift from sweep to ejection dominance when moving from canopy into the open patch, while the conditional average showed only sweep dominated transport. In contrast to a homogeneous canopy layout, below canopy height at the canopy edge, sweeps and ejections lose their dominance in vertical turbulent transport. The present results show that the dynamics of internal interfaces govern the ensemble averaged results and a possible implementation into existing models is proposed. The present results are expected to increase understanding of spanwise turbulent transport and aid in developing strategies to mitigate desertification.
Regional lymph node changes on breast MRI in patients with early-stage breast cancer receiving neoadjuvant chemo-immunotherapy
Authors: Jacob Saya , Christofferson Anika , Fisch Samantha , Norwood Peter , Castillo Paolo , Yu Hongmei , Hirst Gillian , Soliman Hatem , Nanda Rita , Mukhtar Rita A. , Ewing Cheryl , Majure Melanie , Melisko Michelle , Rugo Hope S. , Esserman Laura , Price Elissa , Chien A. Jo
Published: September 2024

Purpose

Establishing breast MRI imaging patterns associated with neoadjuvant immunotherapy is needed to monitor response. We analyzed serial breast MRIs in patients receiving neoadjuvant chemo-immunotherapy on the I-SPY2 clinical trial.

Methods

Patients with stage 2–3 HER2-negative breast cancer were randomized to weekly paclitaxel (control), weekly paclitaxel and pembrolizumab, or weekly paclitaxel, pembrolizumab and intra-tumoral injection of SD-101, a TLR9 agonist. All patients received AC. Regional lymph nodes were retrospectively evaluated on breast MRI at baseline, 3, 12 and 20 weeks by a single blinded radiologist. MRIs were assessed for development of new regional lymphadenopathy, or increase in the longest diameter or cortical thickness of the largest abnormal regional lymph node.

Results

Between 12/2015 and 4/2021, a total of 43 patients enrolled in the control (n = 16) and paclitaxel + pembrolizumab ± SD-101 (n = 27) arms. 12 of 27 patients (44.4%) receiving chemo-immunotherapy experienced increased lymphadenopathy within the first 12 weeks compared to 1 of 16 patients (6.3%) in the control group (p = 0.014). Most patients with increased lymphadenopathy were in the SD101/pembro arm (n = 10, p = 0.002). Increased lymphadenopathy was observed despite concomitant decrease in breast tumor size at all time points. 11 of 12 patients with increased lymphadenopathy had pathologically negative nodes at surgery. There was no association between lymphadenopathy and lower residual cancer burden or immune-related toxicity.

Conclusions

The combination of neoadjuvant paclitaxel and pembrolizumab ± SD101 intratumoral injection was associated with early increases in regional lymphadenopathy on MRI despite decreased breast tumor size. Increased lymphadenopathy was not associated with node positive disease at surgery.
To Belong: Narratives About Family Belonging Among Children in Foster Families or Where Custody has been Transferred
Authors: Larsson Sara , Punzi Elisabeth , Wissö Therése
Published: September 2024

Background

In 1983, 2001, 2002 and 2020 Swedish legislation has sought to strengthen children’s rights to family belonging in foster care, as well as their voices in decision making. The aim of this study was to understand how children in long-term foster families and children whose custody has been transferred experience family belonging within these different legal contexts. Methods: Six participants aged 11–17 years were recruited. The data were collected through narrative interviews. Both verbal and visual methods were used in data collection and narrative analysis was used to capture a comprehensive understanding of the stories. Findings: It is suggested that a sense of family belonging can be understood through the following themes: “To spend time”, “To share experiences”, “To be seen, cared for, and supported”, “To resemble someone”, and “To know or not to know”. Conclusion: Practical implications of the findings are discussed in relation to planning, guidance, and decision-making within foster care. The results, if implemented in practice, could have an impact on how to discuss foster children’s sense of family belonging within the foster care system.
Multi-marker analysis of circulating tumor cells in localized intermediate/high-risk and metastatic prostate cancer
Authors: Welsch Eva , Bonstingl Lilli , Holzer Barbara , Schuster Eva , Weiß Esther , Zaharie Alexandru-Teodor , Krainer Michael , Fischer Michael B. , El-Heliebi Amin , Zeillinger Robert , Obermayr Eva
Published: September 2024

Circulating tumor cells (CTCs) are an established prognostic marker in metastatic prostate cancer (PrC) but have received little attention in localized high-risk disease. Peripheral blood was obtained from patients with early intermediate and high-risk PrC (n = 15) at baseline, after radiotherapy, and during follow-up, as well as from metastatic PrC patients (n = 23). CTCs were enriched using the microfluidic Parsortix® technology. CTC-related marker were quantified with qPCR and RNA in-situ hybridization (ISH). Positivity and associations to clinical parameters were assessed using McNemar test, Fisher Exact test or log-rank test. The overall positivity was high in both cohorts (87.0% metastatic vs. 66.7% early at baseline). A high concordance of qPCR and RNA ISH was achieved. In metastatic PrC, PSA and PSMA were prognostic for shorter overall survival. In early PrC patients, an increase of positive transcripts per blood sample was observed from before to after radiation therapy, while a decrease of positive markers was observed during follow-up. CTC analysis using the investigated qPCR marker panel serves as tool for achieving high detection rates of PrC patient samples even in localized disease. RNA ISH offers the advantage of confirming these markers at the single cell level. Employing the clinically relevant marker PSMA, our CTC approach can be used for diagnostic purposes to screen patients profiting from PSMA-directed PET-CT or PSMA-targeted therapy.
Spatiotemporal dynamics of Phytophthora infestans airborne inoculum in Belgium
Authors: Le Vourch Vivien , Decroës Alain , Thonon Salomé , Lienard Charlotte , Van Steenberge Cyril , Rosillon Damien , Lebrun Pierre , César Vincent , Legrève Anne
Published: September 2024

For nearly a century, scientists have strived to model the development of Phytophthora infestans (Pi) to predict late blight infections in potatoes. This has led to the use of decision support systems (DSSs) that rely on forecasting models based on environmental parameters. All these models assume that the primary inoculum is ubiquitous. This study focuses on the spatiotemporal distribution of airborne inoculum of Pi to assess the value of incorporating quantitative data of this variable in improving the prediction of primary infection of potato late blight in fields. The daily spatiotemporal distribution of Pi airborne inoculum was studied from 2019 to 2022 at Ath, Gembloux, Libramont and Louvain-la-Neuve in Belgium by combining Burkard spore traps with a quantitative PCR assays. The quantities of Pi inoculum trapped daily ranged from 0 to 4903 (expressed as sporangia equivalent) depending on the site and the year. The appearance of late blight symptoms in untreated plots located close to spore traps was assessed shortly after the detection of airborne inoculum in all monitored sites. A comparison between airborne inoculum detection and the recommendations provided by three DSSs revealed that fungicide treatments are often recommended at the beginning of the season when airborne inoculum is absent. Two field trials performed in 2021 and 2022 showed that the number of fungicide treatments could be reduced by considering the presence of the inoculum, particularly by delaying the first application. Further knowledge of the relationships between disease pressure, airborne inoculum and meteorological conditions will provide valuable information for improving DSSs and reducing fungicide use.
Spreading of rotating liquid annular ring with hysteresis effects
Authors: Boettcher Konrad E. R. , Ehrhard Peter
Published: September 2024

The spreading of a liquid, subjected to centrifugal forces or an air jet, leads to a lowering of the liquid height at the center. If the system is partially wetting, experiments show a break up of the liquid and the appearance of a dry patch at the center. In this article, the spreading of a liquid droplet or a liquid film, featuring a dry patch at the center, is investigated. Via a generalized Tanner’s law, we allow for a contact-angle hysteresis in partially wetting systems. By means of the lubrication approximation, an analytical quasi-steady solution can be derived in the limit of small capillary numbers. We find a power-law regime for the spreading, in which at least one of the contact lines follows a power law in time, almost independent of both static contact angles. The influence of the static contact angles remains restricted to the beginning of the spreading and to transition periods. Four different types of spreading can be identified, namely spreading (i) with a very thin central liquid layer, (ii) as annular ring with central dry patch, (iii) into a static equilibrium, and (iv) with closing of the central dry patch. In a flow map, these types of spreading are mapped as function of both static contact angles. Moreover, the dependency from gravitational and centrifugal forces is investigated and included in the flow map. For a perfectly wetting system, a disjoining-pressure correction in combination with Tanner’s law prohibits negative liquid heights at the center. Hereby, the magnitudes of the Hamaker constants have a negligible influence and arbitrary-small values can be used, since the dynamics of the contact line remains controlled by Tanner’s law.
Deservingness Belongs to the Past
Authors: Andersson Alexander
Published: September 2024

It has been suggested that people who will face hardship in the future may deserve our sympathies now. Similar intuitions can be adopted regarding the deservingness of jobs and scholarships, where andidates may be deserving now based on their expected future performance. To accommodate these intuitions, some have contended that desert is sometimes forward-looking. In this paper, I argue that it is a mistake to think of desert as forward-looking. The forward-looking view struggles to explain the deservingness of subjects that have conflicting desert-making features in the future, it requires that we accept asymmetries and exceptions in desert theory and that we commit to a form of moderate determinism. In response, I present a comparative approach that offers a unified framework for explaining forward-looking cases without the drawbacks associated with the forward-looking view.
The Global Energy Balance as Represented in Atmospheric Reanalyses
Authors: Wild Martin , Bosilovich Michael G.
Published: September 2024

In this study, we investigate the representation of the global mean energy balance components in 10 atmospheric reanalyses, and compare their magnitudes with recent reference estimates as well as the ones simulated by the latest generation of climate models from the 6th phase of the coupled model intercomparison project (CMIP6). Despite the assimilation of comprehensive observational data in reanalyses, the spread amongst the magnitudes of their global energy balance components generally remains substantial, up to more than 20 Wm−2 in some quantities, and their consistency is typically not higher than amongst the much less observationally constrained CMIP6 models. Relative spreads are particularly large in the reanalysis global mean latent heat fluxes (exceeding 20%) and associated intensity of the global water cycle, as well as in the energy imbalances at the top-of-atmosphere and surface. A comparison of reanalysis runs in full assimilation mode with corresponding runs constrained only by sea surface temperatures reveals marginal differences in their global mean energy balance components. This indicates that discrepancies in the global energy balance components caused by the different model formulations amongst the reanalyses are hardly alleviated by the imposed observational constraints from the assimilation process. Similar to climate models, reanalyses overestimate the global mean surface downward shortwave radiation and underestimate the surface downward longwave radiation by 3–7 Wm−2. While reanalyses are of tremendous value as references for many atmospheric parameters, they currently may not be suited to serve as references for the magnitudes of the global mean energy balance components.
“We Met in a Place that Fostered Exploring”: Campus Environments that Influence Boundary-Crossing Friendships
Authors: Hudson Tara D. , Rockenbach Alyssa N.
Published: September 2024

The college years represent a prime opportunity for students to develop prosocial skills through friendships that cross social boundaries (i.e., in which the two friends differ on at least one aspect of sociocultural identity such as race, political affiliation, or religion). By cultivating empathy and reducing social stratification, these friendships may serve as a needed remedy for the ongoing and deepening tribalism dominating the current U.S. political climate, ultimately advancing a more justice-oriented society. We utilized data from 55 focus groups with 268 participants at 18 U.S. institutions of various sizes, locations, and affiliations to explore how campus environments and experiences influence college students’ boundary-crossing friendships. Participants highlighted how aspects of their campus climates (size, structural diversity, norms, and identity support) encouraged as well as discouraged crossing social boundaries. They discussed how programs (curricular and co-curricular), spaces (residence and dining halls, prayer spaces), and informal social opportunities (such as studying, dining, socializing, or having meaningful conversations) helped them develop and deepen friendships across the social boundaries of religious, secular, and spiritual (RSS) identity; political beliefs; race/ethnicity; and other identities. They also described the power of early campus experiences in setting the stage for crossing social boundaries. Our findings add texture to prior quantitative research documenting the power of campus conditions and environments for fostering friendship across social boundaries, and they illuminate effective ways for colleges and universities to create environments and experiences that provide students with opportunities and reasons to connect and build friendships that bridge social divisions.
Journalism Beyond the Nation-State: Multiscalar Fields and How to Navigate Them
Authors: Zeveleva Olga
Published: September 2024

Analysis of journalistic fields is dominated by approaches that take news media at the nation-state level as the major unit of analysis. More recently, sociologists have asked whether we can speak of global journalistic fields. Many scholars have concluded that global journalistic fields are weak at best, and news production remains bounded by nation-states. This paper offers a more fine-tuned understanding of the boundaries of journalistic fields. Drawing on an interview-based qualitative study of regional journalistic fields in contemporary Crimea (a region of Ukraine annexed by Russia in 2014) and in Tatarstan (a region of Russia), I answer the questions “how do states shape the autonomy of regional journalistic fields?” and “how do journalists navigate the limitations they face?” I advance two arguments: first, journalistic fields can be understood as multiscalar fields, and the practices of journalists are shaped by the configuration of political relations along different scales simultaneously (the scale of the city, the region, the national scale, the scale of other nation-states, and the international arena). Second, the scales that exert the most influence on journalistic fields can change depending on whether the nation-state or the region is embroiled in conflict.
Prescription of Exercise Programs for Individuals with Autism Spectrum Disorder: Systematic Review
Authors: Ataíde Sofia S. , Ferreira José P. , Campos Maria J.
Published: September 2024

Physical exercise offers health benefits for individuals with autism spectrum disorder (ASD). However, the literature on recommendations for exercise prescription is still limited. This study aims to identify the most beneficial type of exercise program and present the most effective guidelines for its prescription in individuals with ASD. A systematic review was carried out using the ERIC, Web of Science, PsycINFO, PubMed and Scopus databases in accordance with the PRISMA guidelines. Of a total of 1114 studies, 18 were considered eligible. Overall, the type of programs included aerobic exercise sessions with an average duration of 12 weeks, with 3 weekly sessions of 45 to 60 min. The assessment included the shuttle test protocol, the progressive cardiovascular endurance running protocol and the modified Bruce protocol. For the muscle strength exercises, the sessions lasted an average of 12 weeks, with 2 weekly sessions of 10 to 20 min, including 2 to 4 exercises, 1 to 3 sets, with 6 to 12 repetitions. The assessments included the handgrip strength test, the modified curve-up test and the push-up test. The programs had positive effects on cardiorespiratory capacity and hemodynamics, indicating that the benefits of training increase when both capacities are combined. This study provides useful guidelines for adapted sports coaches to prescribe exercise programs aimed at promoting quality of life in individuals with ASD.