bluuebunny/crossref_metadata_2025 huggingface dataset:
Proposal of a new dermoscopic criterion for pigmented basal cell carcinoma: a multicentre retrospective study
Authors: Manca Roberto , Dattolo Anna , Valenzano Francesco , Castriota Marina , Martella Alessandro , Galdo Giovanna , Argenziano Giuseppe , Abeni Damiano , Fania Luca
Published: August 2023

Dermoscopy is widely used for the diagnosis of skin cancers and it increases the accuracy of basal cell carcinoma (BCC) detection. The dermoscopic criteria of BCC have recently been updated and they can be divided into three categories: vascular, pigment-related, and nonvascular/nonpigmentrelated. The objective of our multicentre retrospective study was to report the validity of a new dermoscopic pigment-related feature utilized to detect pigmented BCC (pBCC) (i.e., brown homogeneous blotches (BHB)). Cases of pBCC were collected from the databases of IDI-IRCCS of Rome and from three Italian private dermatology centres. BHB were defined as the presence of circumscribed areas of brown homogeneous pigmentation which are devoid of any dermoscopic specific arrangement (net, fat fingers, etc.) and of other internal dermoscopic structures, except for occasional vascular ones, such as arborizing vessels or globules/dots. Controls included melanocytic and non-melanocytic lesions. We examined images of 270 pigmented lesions (female 145; 51.8%) including 90 histopathological proven pBCC and 180 control cases (i.e., 90 melanocytic and 90 non-melanocytic lesions). BHB were present in 61 cases of 90 pBCC. These results showed a sensibility of 67.8 and a specificity of 93.3 with a positive predictive value of 83.6, negative predictive value of 85.3, posLR 10.2, negLR 0.3; OR 29.4, P value<0.001. Our multicentre retrospective study showed that the BHB may represent a new dermoscopic criterion for the diagnosis of pBCC.
Isotretinoin-unresponsive acne as a sign of a congenital disorder: a case of 21-hydroxylase deficiency
Authors: Marzola Elisa , Bettoli Vincenzo
Published: August 2023

Acne is a multifactorial disorder, very common among young people, and a frequent reason for Dermatology consultation. When moderate-to-severe acne is not responsive to conventional treatments, oral isotretinoin is a very effective solution. However, there are cases in which this treatment too fails to produce the expected result. In this case, an 18-year-old male patient with acne, unresponsive to traditional acne therapies, experienced only a partial benefit from oral isotretinoin. Endocrinology consultation and hormonal work-up revealed androgen metabolism anomalies suggestive of a non-classical form of congenital adrenal hyperplasia due to 21-hydroxylase deficiency. In this case report, the authors discuss when to suspect, how to diagnose, and how to manage similar cases.
Secondary lymphomas of the skin
Authors: Pileri Alessandro , Sacchelli Lidia , Mussi Marina , Cedirian Stephano
Published: August 2023

Skin can be primarily involved by a lymphoma or can be colonised by a systemic disease. Hence, two categories of lymphoma can be distinguished: the primary cutaneous lymphoma (PCL) and the systemic lymphoma that secondarily involves the skin, also known as secondary cutaneous lymphoma (SCL). The aim of the present review is to analyse the current knowledge of such neglected topic. SCL were then analysed from a clinical, histological and survival ground.
Unilateral eosinophilic fasciitis (Shulman syndrome) with excellent response to combined treatment with methotrexate therapy and compression brace
Authors: Zengarini Corrado , Clarizio Giacomo , Bardazzi Federico , Mussi Martina , Baraldi Carlotta , Piraccini Bianca Maria , Pileri Alessandro
Published: August 2023

Not available
CNS Melioidosis
Authors: Shobhana A , Datta Ashis , Trivedi Santosh
Published: August 2023

Melioidosis is an emerging tropical disease. Central nervous system (CNS) melioidosis may present as a brain abscess or encephalomyelitis mimics tuberculosis. Early diagnosis and management decreases mortality as well as morbidity. This case of brain abscess and encephalomyelitis in a young man with no known comorbidities was a diagnostic challenge. The surgery helped in debulking as well as isolating the causative organism. Appropriate antibiotic therapy for melioidosis was lifesaving and prevented further complications.
Corticospinal Tract Involvement in MRI of Neuromelioidosis
Authors: Raj Joe Vimal , Nagarajan Krishnan , Ananthanarayanan Kasinathan , Swaminathan Rathinam P. , Bammigatti Chanaveerappa
Published: August 2023

Melioidosis is gram-negative bacterial infection endemic in parts of Australia and Asia with significant morbidity and mortality. It is acquired in wet rainy seasons through occupational and recreational activities. Although central nervous system (CNS) involvement is seen in less than 10%, it can have severe sequelae. MRI (magnetic resonance imaging) findings in reported cases have shown predominant brain stem and frontoparietal involvement. We present three pediatric cases of neuromelioidosis in which corticospinal tract involvement was a characteristic finding.
Evaluation of Neuropatic Pain Features in COVID-19 Patients
Authors: Ocak Özgül , Sahin Erkan Melih
Published: August 2023

Background:

Pain is a common complaint in COVID-19 disease. Neurotrophic features of the COVID virus are reported. Neuropathic pain is seen during many viral infections and observed during the COVID-19 pandemic part of the clinical presentations.

Objective:

The aim of this is to evaluate neuroptic pain as presenting symptom in COVID-19 patients.

Materials and Methods:

In this cross-sectional descriptive study, adult patients (18 years and older) who applied to the COVID Outpatient Clinic completed the demographic data form and the neuropathic pain questionnaire. The patients were divided into positive and negative according to the PCR test results and the presence of neuropathic pain was compared.

Results:

In total, 440 participants included in the study. Among 301 who stated to had any complaints, 197 (65.4%) had pain. The intensity of their pain was 5.8 ± 2.4 (0 – no pain and 10 – the most severe pain of life). Neuropathic pain component was present in 29.2% of the patients. Among the first admissions, neuropathic pain component was observed significantly higher in those with positive PCR test (55.0%) than negative ones (23.8%), and the Odd's ratio was calculated as 3.911.

Conclusions:

COVID-19 virus is thought to have neuroinvasion and neurotropic effects. In this study, neuropathic pain specifically was evaluated in COVID-19 patients, and the frequency of neuropathic pain was significantly higher in PCR confirmed COVID-19 patients at the onset of the disease.
Neurological Disorders in Literary Fiction
Authors: Marquez-Romero Juan M
Published: August 2023

Background:

Across literary fiction, allusions to medical ailments are common. However, in the bibliography of Stephen King, neurological disorders appear to be present disproportionately.

Objective:

The objective of this study is to describe the epidemiology of neurologic disorders depicted in the writings of Stephen King.

Methods:

This study presents data from Stephen King's 60 published novels. The frequency, prevalence, lethality, and mortality of each neurological diagnosis found in the characters that appear in the novels are reported.

Results:

Forty-eight novels portrayed at least one character with a neurological diagnosis, and in total, 150 characters exhibited a neurological condition. The overall prevalence was 111.2 per 1,000 characters. Their median age was 20 years (range 76), and 61.7% were males. Headache was the most common symptom (35.3%), followed by stroke symptoms in 28.7%. Prevalence was 24.5, 17.8 for headache and epilepsy, respectively. Lethality was 28.7%. The overall mortality rate was 31.9.

Conclusions:

The epidemiology described in Stephen King's novels parallels that of the real world. The depiction of neurological disorders found in his novels showcases the elevated contribution of neurological disorders to the global burden of the disease, an important message for the readers of his fiction and interest to all neurologists.
Prof. B. Ramamurthi – A Glimpse into his Contributions to Neuroscience
Authors: Sridhar K , Mohan Rao K Santosh
Published: August 2023

Prof B Ramamurthi was a pioneer of Indian neurosurgery and a major force in the development of Indian neuroscience. Founding the Madras Institute of Neurology and later the A Lakshmipathi Neurosurgical Centre (ALNC), both at Madras (or Chennai as it is now called), he developed centres of excellence in his career that spanned over five decades. During this period of time he made Madras, a destination for neurosurgery and neuroscience. Along with his colleagues a large number of publications were produced which influenced the world. Notable among his contributions were those in Stereotaxy for movement disorders, epilepsy, pain and psychiatric illness. He also had notable contributions in brain tumours especially acoustic neurinomas and pituitary tumours. His papers on the low incidence of aneurysms is still quoted widely. Head injuries formed a major part of the neurosurgical work and major contributions were made in that field too. As a developing country with socio-economic issues, infections of the nervous system were seen commonly. His publications on tuberculomas of the brain are noteworthy. He was intrigued by the neurophysiological basis of consciousness. He writings on the subject reflect his attempt to bring together ancient eastern thoughts and concepts of consciousness and life and western science. In the later part of his career he spoke on ethics in and the changing milieu of neurosurgery. While contributions to spinal surgery were not seen in the first half of his career, he along with his colleagues from ALNC published original articles on spinal surgery especially tumours and OPLL. Prof B Ramamurthi, has not only influenced, taught and mentored, during his lifetime, a great many neuroscientists, but he also continues to do so through his publications which continue to be relevant in todays world. A glimpse into his contributions show us how without the technology of today a lot was achieved - and we need to see that, to inspire us to achieve more and to strive for greater heights.
Susceptibility-Weighted MRI as an Imaging Marker for Reperfusion Injury in Acute Ischemic Stroke Following Mechanical Thrombectomy
Authors: Gandhi Jenny M , Cherian P Mathew , Mehta Pankaj , Vardhraj Shriram , Santosh P , Elango S
Published: August 2023

Background/Purpose:

Following endovascular intervention for stroke, hyperattenuated areas are common in brain parenchyma and it is difficult to differentiate on non-contrast CT whether it is contrast staining or reperfusion hemorrhage. Differentiation between contrast staining from reperfusion hemorrhage is of paramount importance for early initiation of antiplatelets and/or anticoagulants to prevent reocclusion of vessel. This study demonstrates signal characteristics of contrast-staining and reperfusion hemorrhage on susceptibility weighted MRI and its role to differentiate between two.

Materials/Methods:

Between July 2017 to March 2019, 36 patients who presented with acute ischemic stroke due to large vessel occlusion underwent mechanical thrombectomy. Low-osmolar non-ionic (Iopromide 300 mg/L) iodinated contrast was used in all patients who underwent endovascular intervention. All patients underwent noncontrast CT brain and SWI on 3T MRI within 30 minutes of endovascular intervention. MRI was evaluated by two neuroradiologists. Reperfusion hemorrhage was defined as ECASS criteria II. Symptomatic ICH was defined as hemorrhagic transformation temporally related to a negative shift in NIHSS score >/=4.

Results:

Out of 36 patients, 15 had hyperattenuated areas in brain on NCCT. Out of 15, 13 patients had blooming on SWI, suggestive of bleed. Two patients had no blooming on SWI, suggestive of contrast staining. Two patients didnot show any hyperdensity on NCCT but blooming on SWI, suggestive of bleed.

Conclusion:

All patients with hyperdensity on NCCT secondary to bleed showed blooming on SWI whereas those with contrast staining didnot show any signal changes on SWI. Thus, it is possible to differentiate reperfusion hemorrhage from contrast staining using SWI MRI. The significance of SWI in normal CT may be low where a small bleed maynot have any clinical significance.
Probable Silodosin-Induced Diplopia
Authors: Cotelli Maria Sofia , Bandera Floriana , Bandera Giuseppe , Bonetti Stefano , Manelli Filippo , Turla Marinella
Published: August 2023

Diplopia, or double vision, is a symptom resulting from the perception of two images of a single object. We report a case of a possible silodosin-induced diplopia never reported before in the literature. We suggest that binocular diplopia should be considered in people assuming silodosin even if further studies should be conducted to explore possible pathogenetic mechanisms.
Is Air Pollution Associated with Increased Risk of Dementia? A Meta-Analysis of Epidemiological Research
Authors: Dhiman Vikas , Trushna Tanwi , Raj Dharma , Tiwari Rajnarayan R.
Published: August 2023

Background:

There are prevailing inconsistencies in epidemiological research about air pollution being a risk factor for dementia.

Objective:

We performed meta-analyses to calculate the pooled estimates of the risk of developing dementia due to air pollution exposure.

Methods and Materials:

We performed a systematic search in PubMed, Google Scholar, The Cochrane Library, and J-GATEPLUS databases for peer-reviewed epidemiological studies reporting the risk of developing all-cause dementia, cognitive decline, Alzheimer's disease (AD), and vascular dementia (VaD) due to exposure to particulate matter with an aerodynamic diameter less than 2.5 μm (PM2.5) and less than 10 μm (PM10), ozone (O3), carbon monoxide (CO), nitrogen dioxide (NO2), nitrogen oxides (NOX) and sulfur dioxide (SO2) from the beginning until December 2020. Meta-analysis was performed by adopting the random-effects model using Meta-XL.

Results:

In all-cause dementia, the pooled hazard ratio (HR) for PM2.5 and NO2 exposure was 1.03 [(95%CI: 1.01–1.06; I2 = 99% (P < 0.001)] and 1.00 [(95%CI: 1.00–1.01; I2 = 96% (P < 0.001)], respectively. The pooled HR for NOX was 1.00 [(95%CI: 1.00–1.01; I2 = 61% (P = 0.05)]. In AD, the pooled HRs for PM2.5 and O3 was 1.08 (95%CI: 1.01–1.15; I2 = 99% (P < 0.001)]) and 1.02 (95%CI: 0.96–1.08; I2 = 100% (P < 0.001)], respectively. In VaD, the pooled HR for PM2.5 exposure was 1.03 (95%CI: 1.01–1.06; I2 = 91% (P < 0.001)]. In NO2/NOX, the results were found to be equivocal. Meta-analysis could not be performed in cognitive decline because of wide variations in assessments methods.

Conclusions:

The present study showed exposure to PM2.5 as a risk factor for all-cause dementia, AD, and VaD and exposure to O3 as a possible risk factor for AD. These findings can be used for policy measures and further research.
Primary Histiocytic Sarcoma of Brain—Illustration of Two Cases with Varied Histomorphological Features
Authors: Rajeshwari Madhu , Suri Vaishali , Sarkar Chitra , Garg Ajay , Sharma Mehar Chand
Published: August 2023

Histiocytic sarcoma (HS) is an aggressive hematolymphoid malignancy that arises from non Langerhans histiocytes and usually involves the skin, lymph nodes, and intestine. The involvement of the central nervous system (CNS) is a rare occurrence with around 30 cases being reported in English literature. Morphological and immunohistochemical evidence of histiocytic differentiation is essential for diagnosis. Prognosis is very poor and consensus on treatment is not available mainly due to its rarity. We report two cases of HS with varied clinical presentation and pathological findings and elucidate the diagnostic challenges of this rare entity.
Fahr's Disease and Hypoparathyroidism – A Missing Link
Authors: Subbiah Sridhar , Natarajan Vasanthiy , Bhagadurshah Rameez Raja
Published: August 2023

Fahr's disease is an idiopathic basal ganglia calcification with autosomal dominant inheritance. Prior to diagnosing Fahr's disease based on computed tomography (CT) and/or magnetic resonance imaging (MRI) of the brain, one should rule out hypoparathyroidism (HP), and pseudohypoparathyroidism (PHP). Treatments of these conditions are entirely different. HP- and PHP-related hypocalcemia requires calcium, calcitriol, and vitamin D therapy in a long run to avoid recurrent seizures whereas Fahr's disease is treated with an antiepileptic alone.
Silver Needle Thermal Therapy Relieves Pain, Repairs the Damaged Myofascial Fiber, and Reduces the Expression of 5-HT3 Receptors in the Spinal Cord of Rats with Myofascial Pain Syndrome
Authors: Lv Xianglong , Wo Chunxin , Yao Jing , Lu Wei , Yu Zilong , Qin Yue , Wang Yue , Zhang Zhongjie , Wu Yu , Huang Yuanxin , Wang Lin
Published: August 2023

Background:

There is an urgent clinical need to provide a theoretical basis for silver needle thermal therapy to Myofacial pain syndrome (MPS).

Objective:

This study was conducted to explore the effect of silver needle thermal therapy on myofascial pain syndrome in rats.

Methods:

MPS rat models were duplicated, and the rats were subsequently divided into model and treatment groups. A normal control group was synchronously set up. No treatment was given to the model group, whereas silver needle thermal therapy was administered to the treatment group. The thermal and mechanical pain threshold, the morphological structure as well as the expression of 5-HT3 receptors in the spinal cord were observed.

Results:

Rats from the treatment group presented with a significantly higher pain threshold compared to the untreated model group. The myofascial arrangement of the affected part of the model group was disordered, and some muscle fibers were atrophied and deformed. Meanwhile, the myofascial arrangement of the treatment group became more regular than that of the model group. The expression levels of 5-HT3 receptor in the spinal cord of the untreated model group were significantly increased, while being markedly decreased in the treatment group.

Conclusions:

Silver needle thermal therapy can augment the pain threshold of rats with MPS, repair the damaged myofascial membrane in the rats, and further reduce the expression of 5-HT3 receptors in the spinal cord of the MPS rats.
Non Dysraphic Intramedullary Spinal Cord Lipoma
Authors: Balachandar D , Naidu P Bhaskar , . Sangeetha , Selvakumar K
Published: August 2023

Among all intramedullary spinal cord lesions, intramedullary spinal cord lipomas account less than 1%. Non-dysraphic intramedullary lipoma is very rare. It is most commonly seen in cervicodorsal region followed by cervico bulbar, lumbar and sometimes multiple. Here we present a 17-year-old female who underwent MRI due to upper dorsal pain followed by progressive bilateral lower limb weakness which showed intramedullary lesion extending from T1-T9, involving eight vertebral segments with distal syrinx and features suggestive of lipoma. Patient underwent surgical decompression of lipoma. Patient had an uneventful post-operative period. Diagnosis confirmed by histopathology.
Introduction of Spring-Assisted Cranioplasty for Bicoronal Synotosis in India
Authors: Chattopadhyay Debarati , Vathulya Madhubari , Kapoor Akshay , Arora Rajnish
Published: August 2023

Background:

Various surgical techniques for cranial reconstruction of patients with bicoronal synostosis have been suggested. The outcome is, however, still often suboptimal.

Methods:

In a 5-month-old child with apert syndrome, following a craniotomy incision, lambdoid suturotomy was done bilaterally. Two springs were implanted bilaterally over the lambdoid sutures. Cephalic index was obtained from three-dimensional computed tomography scans, and photographs were analyzed for aesthetic evaluation.

Result:

The preoperative calvarial shape was hyperbrachycephalic. The CI improved from 92 to 83 units. Duration of surgery was 1 h 45 min, blood loss was 30 mL, and total hospital stay was 3 days. No major complications were observed. Spring removal was done at 6 months postoperatively and frontoorbital advancement performed.

Conclusion:

Spring-assisted cranioplasty for bicoronal synostosis is a safe and elegant technique, is less invasive than many other cranioplasties, and results in marked improvement in the calvarial shape.
Spontaneous Cerebral Air Embolism–An Unusual Scenario
Authors: Bansal Rishu , Bhuyan Sushant , Gupta Rajiv , Garg Arun , Bansal Atma R
Published: August 2023

The introduction of air into cerebral venous or arterial circulation known as cerebral air embolism (CAE) is a rare clinical entity. CAE is commonly iatrogenic secondary to central venous catheter (CVC) placement or removal, various endoscopic procedures, or trauma or surgical scenarios. Here we report a case of spontaneous CAE in an unusual scenario. A 71-year-old male presented to emergency after developing giddiness following a yoga session. His MRI showed air embolism in the posterior fossa along cerebellar folia, prepontine, and suprasellar cisterns and tracking superiorly along the tentorium cerebelli. CAE is a rare clinical entity. Our case had CAE as a complication of cholesteatoma and possibly got triggered due to change in air pressor dynamics during yoga session.
Relation of polycystic ovarian syndrome phenotypes with cutaneous and biochemical hyperandrogenism
Authors: Abouzeid Samy A. , Abou Khadr Nouran A. , Gaafar Sherif S. , Eldeeb Marwa E.
Published: August 2023

Background

Understanding of polycystic ovarian syndrome (PCOS) and its phenotypes with the heterogeneous manifestations and hormonal armamentarium has been not fulfilled.

Objective

To elucidate dermatologic manifestations in Egyptian PCOS cohort, association of each manifestation with hormonal change, and relation of these findings with different phenotypes of PCOS.

Patients and methods

In this case–control study, 95 women who met the criteria of diagnosis of PCOS based on Rotterdam Consensus criteria 2003 and 50 age-matched controls underwent skin examination, anthropometric measurements (height, weight, BMI, and waist circumference), hormonal assays (total and free testosterone, dehydroepiandrosterone sulfate, prolactin, and thyroid-stimulating hormone), and homeostatic model of insulin resistance.

Results

Women with PCOS showed significantly higher BMI (30.71±5.94 kg/m2), waist circumference (99.94±13.01 cm), prevalence of cutaneous manifestations of hyperandrogenism (HA), total and free testosterone, dehydroepiandrosterone sulfate, and homeostatic model of insulin resistance than controls. Hirsutism was the most prevalent skin finding (45.3%) and was the only one significantly associated with elevated serum androgens. Cutaneous HA overwhelming occurred in 82%, whereas biochemical HA was detected in 55.7 % of patients with PCOS. The prevalence of PCOS phenotypes was A (55.8%), B (8.4%), C (25.3%), and D (10.5%). Cutaneous HA and biochemical HA were the most common in phenotype A and least in phenotype D and intermediate in phenotypes B and C.

Conclusion

The effect of PCOS on skin seems to be greater than on serum androgen levels. Hirsutism was the most prevalent cutaneous feature and the only major indicator of HA, followed by acne. A small percentage of patients with PCOS can show neither clinical nor biochemical HA. Phenotype A was the most severe, whereas phenotype D was the least severe, and B and C were intermediate forms.
Protocol of Kasr Al-Ainy’s phototherapy unit − Cairo University for the management of photoresponsive skin diseases − part 1
Authors: El-Mofty Medhat A. , Mostafa Wedad Z. , Esmat Samia M. , Youssef Randa M. , Bosseila Manal A. , Mahgoub Doaa A. , Nagui Noha A. , Elramly Amany Z. , Mashaly Heba M. , Hegazy Rehab A. , El-Hawary Marwa S. , Hussein Marwa F. , Elmasry Maha F. , Shalaby Suzan , Said Eman R. , Ibrahim Sarah
Published: August 2023

One of the most commonly used and effective lines of treatment in chronic skin diseases is phototherapy. A protocol of the Kasr Al-Ainy Phototherapy Unit has been proposed for the treatment of different dermatological diseases such as psoriasis, mycosis fungoides, and vitiligo based on the best current research-based guidelines and the experience of the phototherapy team. This protocol is the cornerstone of the everyday practice in Kasr Al-Ainy Phototherapy Unit and we believe dermatologists dealing with such diseases in their hospitals or clinics, can find it helpful and applicable to get better results with their patients. In part 1, the general measures of the protocol will be discussed.
A dermoscopic study in the diagnosis of plaque psoriasis as compared with contact dermatitis, lichen planus, and pityriasis rosea in Indian patients
Authors: Abdul-Azeez Faizy J. , Raj Aswathi , Pinto Malcolm , Vishal Bejai , Hegde Spandana P. , Ibal Amina Asfiya M. , Manjunath Shenoy M.
Published: August 2023

Background

Dermoscopy is a noninvasive diagnostic tool to visualize clinical patterns of various pigmented skin lesions. Dermoscopy improves the accuracy of the clinical diagnosis of papulosquamous disorders like psoriasis as an additional measure. This in turn avoids the need for invasive diagnostic techniques like skin biopsy.

Objective

To record the dermoscopic findings in plaque psoriasis (PP), chronic dermatitis (CD), lichen planus (LP), and pityriasis rosea (PR).

Patients and methods

A case–control study was conducted on 130 patients: 65 patients diagnosed with PP as cases and 65 patients with a diagnosis of CD, LP, and PR as controls. Patients of any age and sex, irrespective of duration of the disease, were included in the study. The single most recently developed lesion of each patient was evaluated with a Heine delta 20 plus dermoscope.

Results

A combination of regularly distributed dotted vessels over a light-red background associated with diffuse white scales was highly predictive of PP. CD showed similar proportion of patients with patchy and peripheral distribution of scales with a network-like pattern. All the cases of LP revealed Wickham’s striae with a reticulate pattern. White-colored collarette of scaling on a yellow background was characteristic of PR.

Conclusion

Dermoscopy is emerging as an essential supplement to clinical examination in general dermatology. Visualization of specific dermoscopic features enhances the diagnostic utility of nonpigmented skin disorders. Knowledge of specific dermoscopic patterns can enable a clinician solve diagnostic dilemmas in various papulosquamous diseases.
Financial Literacy among Health-Care Professionals in India
Authors: Bhatacharya Sudip , Kumar Subodh , Panigrahi Sunil , Ayub Arshad , Boratne Abhijit , Jahnavi G. , Richa  , Singh Divyanshu , Venugopal Vinayagamoorthy , Gautam Anuradha
Published: August 2023

In India, financial literacy among health professionals is a topic of growing importance, as these professionals often earn a significant income but may not have the necessary knowledge or skills to manage their finances effectively. To address this issue, there is a need for financial literacy programs that are specifically designed for health professionals in India. These programs can provide education on topics such as budgeting, saving, investing, retirement planning, and debt management. They can also help health professionals develop better financial habits and improve their overall financial well-being.
Stigma Experienced by Persons Infected with COVID-19
Authors: Nirmala Berigai Parthasarathy , Sharma Manoj Kumar , Cherian Anish V. , Srikanth Pallerla , Mallesh S. , Raju Kanmani T.
Published: August 2023

Background:

The COVID-19 pandemic had spread throughout the world very quickly and had impacted all spheres of human life. Person infected with COVID-19 (PIwC-19) faces issues not only with physical health but also with their psychological health and the mental health needs were found to be significant. The stigma and discrimination toward the disease were also extended to the near and dear ones of PIwC-19. The current study is an attempt to explore the stigma experienced by the PIwC-19.

Materials and Methods:

The study used an exploratory research method to assess the stigma experienced by the PIwC-19. The list of PIwC-19 was obtained from the Department of Health and Family Welfare, Karnataka. The study was conducted in South Bangalore after segregating the list. PIwC-19 between ages of 18 and 60 years was included in the study. The Explanatory Model Interview Catalogue Scale was used to assess the stigma and an interview guide developed by researchers was used to assess the manifestations of stigma.

Results:

One-third of the subjects were male (n = 105), studied up to higher secondary (n = 101), married (n = 127), and employed (n = 126), and the mean age of the participants in the study is 39.21 ± 11.04 (years). Many of the participants (62%), (n = 93) have reported severe levels of the stigma.

Conclusion:

It is evident from the current study findings that PIwC-19 experienced moderate-to-severe levels of stigma. The current study has explored the various causes, forms, and consequences of stigma in a small population. Stigma was manifested in family, community, and at workplace, recreational places, and peer groups.
Post-transplant biliary complications using liver grafts from deceased donors older than 70 years: Retrospective case-control study
Authors: Jimenez-Romero Carlos , Justo-Alonso Iago , del Pozo-Elso Pilar , Marcacuzco-Quinto Alberto , Martín-Arriscado-Arroba Cristina , Manrique-Municio Alejandro , Calvo-Pulido Jorge , García-Sesma Alvaro , san Román Ricardo , Caso-Maestro Oscar
Published: August 2023

Tumour rupture of gastrointestinal stromal tumours (GISTs) has been considered to be a remarkable risk factor because of its unfavourable impact on the oncological outcome. Although tumour rupture has not yet been included in the current tumor-node-metastasis classification of GISTs as a prognostic factor, it may change the natural history of a low-risk GIST to a high-risk GIST. Originally, tumour rupture was defined as the spillage or fracture of a tumour into a body cavity, but recently, new definitions have been proposed. These definitions distinguished from the prognostic point of view between the major defects of tumour integrity, which are considered tumour rupture, and the minor defects of tumour integrity, which are not considered tumour rupture. Moreover, it has been demonstrated that the risk of disease recurrence in R1 patients is largely modulated by the presence of tumour rupture. Therefore, after excluding tumour rupture, R1 may not be an unfavourable prognostic factor for GISTs. Additionally, after the standard adjuvant treatment of imatinib for GIST with rupture, a high recurrence rate persists. This review highlights the prognostic value of tumour rupture in GISTs and emphasizes the need to carefully take into account and minimize the risk of tumour rupture when choosing surgical strategies for GISTs.
Clinical efficacy of total laparoscopic splenectomy for portal hypertension and its influence on hepatic hemodynamics and liver function
Authors: Qi Rui-Zhao , Li Zhi-Wei , Chang Zheng-Yao , Chang Wei-Hua , Zhao Wen-Lei , Pang Chuan , Zhang Ying , Hu Xing-Long , Liang Feng
Published: August 2023

Tumour rupture of gastrointestinal stromal tumours (GISTs) has been considered to be a remarkable risk factor because of its unfavourable impact on the oncological outcome. Although tumour rupture has not yet been included in the current tumor-node-metastasis classification of GISTs as a prognostic factor, it may change the natural history of a low-risk GIST to a high-risk GIST. Originally, tumour rupture was defined as the spillage or fracture of a tumour into a body cavity, but recently, new definitions have been proposed. These definitions distinguished from the prognostic point of view between the major defects of tumour integrity, which are considered tumour rupture, and the minor defects of tumour integrity, which are not considered tumour rupture. Moreover, it has been demonstrated that the risk of disease recurrence in R1 patients is largely modulated by the presence of tumour rupture. Therefore, after excluding tumour rupture, R1 may not be an unfavourable prognostic factor for GISTs. Additionally, after the standard adjuvant treatment of imatinib for GIST with rupture, a high recurrence rate persists. This review highlights the prognostic value of tumour rupture in GISTs and emphasizes the need to carefully take into account and minimize the risk of tumour rupture when choosing surgical strategies for GISTs.
Accurate resection of hilar cholangiocarcinoma using eOrganmap 3D reconstruction and full quantization technique
Authors: Cui Da-Peng , Fan Shuang , Guo Ying-Xue , Zhao Qian-Wei , Qiao Yue-Xin , Fei Jian-Dong
Published: August 2023

Tumour rupture of gastrointestinal stromal tumours (GISTs) has been considered to be a remarkable risk factor because of its unfavourable impact on the oncological outcome. Although tumour rupture has not yet been included in the current tumor-node-metastasis classification of GISTs as a prognostic factor, it may change the natural history of a low-risk GIST to a high-risk GIST. Originally, tumour rupture was defined as the spillage or fracture of a tumour into a body cavity, but recently, new definitions have been proposed. These definitions distinguished from the prognostic point of view between the major defects of tumour integrity, which are considered tumour rupture, and the minor defects of tumour integrity, which are not considered tumour rupture. Moreover, it has been demonstrated that the risk of disease recurrence in R1 patients is largely modulated by the presence of tumour rupture. Therefore, after excluding tumour rupture, R1 may not be an unfavourable prognostic factor for GISTs. Additionally, after the standard adjuvant treatment of imatinib for GIST with rupture, a high recurrence rate persists. This review highlights the prognostic value of tumour rupture in GISTs and emphasizes the need to carefully take into account and minimize the risk of tumour rupture when choosing surgical strategies for GISTs.
Risk factors and their interactive effects on severe acute pancreatitis complicated with acute gastrointestinal injury
Authors: Chen Jian-Hui , Zhang Mei-Fen , Du Wen-Chao , Zhang Yan-An
Published: August 2023

Tumour rupture of gastrointestinal stromal tumours (GISTs) has been considered to be a remarkable risk factor because of its unfavourable impact on the oncological outcome. Although tumour rupture has not yet been included in the current tumor-node-metastasis classification of GISTs as a prognostic factor, it may change the natural history of a low-risk GIST to a high-risk GIST. Originally, tumour rupture was defined as the spillage or fracture of a tumour into a body cavity, but recently, new definitions have been proposed. These definitions distinguished from the prognostic point of view between the major defects of tumour integrity, which are considered tumour rupture, and the minor defects of tumour integrity, which are not considered tumour rupture. Moreover, it has been demonstrated that the risk of disease recurrence in R1 patients is largely modulated by the presence of tumour rupture. Therefore, after excluding tumour rupture, R1 may not be an unfavourable prognostic factor for GISTs. Additionally, after the standard adjuvant treatment of imatinib for GIST with rupture, a high recurrence rate persists. This review highlights the prognostic value of tumour rupture in GISTs and emphasizes the need to carefully take into account and minimize the risk of tumour rupture when choosing surgical strategies for GISTs.
Effects of ultrasound monitoring of gastric residual volume on feeding complications, caloric intake and prognosis of patients with severe mechanical ventilation
Authors: Xu Xiao-Yan , Xue Hui-Ping , Yuan Ming-Jun , Jin You-Rong , Huang Chun-Xia
Published: August 2023

Tumour rupture of gastrointestinal stromal tumours (GISTs) has been considered to be a remarkable risk factor because of its unfavourable impact on the oncological outcome. Although tumour rupture has not yet been included in the current tumor-node-metastasis classification of GISTs as a prognostic factor, it may change the natural history of a low-risk GIST to a high-risk GIST. Originally, tumour rupture was defined as the spillage or fracture of a tumour into a body cavity, but recently, new definitions have been proposed. These definitions distinguished from the prognostic point of view between the major defects of tumour integrity, which are considered tumour rupture, and the minor defects of tumour integrity, which are not considered tumour rupture. Moreover, it has been demonstrated that the risk of disease recurrence in R1 patients is largely modulated by the presence of tumour rupture. Therefore, after excluding tumour rupture, R1 may not be an unfavourable prognostic factor for GISTs. Additionally, after the standard adjuvant treatment of imatinib for GIST with rupture, a high recurrence rate persists. This review highlights the prognostic value of tumour rupture in GISTs and emphasizes the need to carefully take into account and minimize the risk of tumour rupture when choosing surgical strategies for GISTs.
Changing trends in gastric and colorectal cancer among surgical patients over 85 years old: A multicenter retrospective study, 2001–2021
Authors: Chen Ke , Li Ming , Xu Ran , Zheng Ping-Ping , Chen Meng-Ding , Zhu Liang , Wang Wen-Bin , Wang Zheng-Guang
Published: August 2023

Tumour rupture of gastrointestinal stromal tumours (GISTs) has been considered to be a remarkable risk factor because of its unfavourable impact on the oncological outcome. Although tumour rupture has not yet been included in the current tumor-node-metastasis classification of GISTs as a prognostic factor, it may change the natural history of a low-risk GIST to a high-risk GIST. Originally, tumour rupture was defined as the spillage or fracture of a tumour into a body cavity, but recently, new definitions have been proposed. These definitions distinguished from the prognostic point of view between the major defects of tumour integrity, which are considered tumour rupture, and the minor defects of tumour integrity, which are not considered tumour rupture. Moreover, it has been demonstrated that the risk of disease recurrence in R1 patients is largely modulated by the presence of tumour rupture. Therefore, after excluding tumour rupture, R1 may not be an unfavourable prognostic factor for GISTs. Additionally, after the standard adjuvant treatment of imatinib for GIST with rupture, a high recurrence rate persists. This review highlights the prognostic value of tumour rupture in GISTs and emphasizes the need to carefully take into account and minimize the risk of tumour rupture when choosing surgical strategies for GISTs.
Low-Temperature Cranking Load Requirements of an Engine—Air Starter Method
Authors:   Vehicle EE System Diagnostics Steering Committee
Published: August 2023

The air cranking system components, which include the tank, valve, hose, and starter, must be carefully selected to provide the necessary speed to start an engine under the most severe climatic conditions for which the system is intended. Engine cranking loads increase with cold temperatures, therefore, the initial selection of these components, needs to consider low-temperature engine torque requirements. To insure an adequate air cranking system is obtained, it is important that proper test procedures are used for obtaining the cranking load requirements of the engine.
Bandırma Tekke Camii Haziresindeki Mezar Taşları
Authors: ACIOĞLU Yusuf
Published: August 2023

Ölen kişiler hakkında birçok bilgiyi barındıran ve kültürel mirasın bir parçası olan mezar taşları, günümüzde farklı disiplinlerin çalışma alanı olmuştur. Yapılan çalışmalar sayesinde yitip giden bu değerlerimizin korunarak gelecek nesillere aktarılması sağlanmaktadır. Bu çalışmada da daha önce tek başına konu edinilmemiş olan, Bandırma ilçe merkezi Haydar Çavuş Mahallesinde yer alan Bandırma Tekke Camii haziresindeki mezar taşları detaylı bir şekilde tanıtılarak alana bir katkı sunulması amaçlanmıştır. Bu kapsamda, caminin güneyinde avlu duvarıyla kuşatılan haziredeki 31 adet mezar taşının fotoğrafları çekilerek, ölçüleri alınmış ve tarihsiz olanlar sonda yer almak üzere kronolojik sırayla kataloğu yapılmıştır. Bunlardan 18’i erkek, 10’u kadın mezar taşı olup 3’nün ise kimliği belirlenememiştir. Mezar taşlarının tarih aralığı 1720/1721 ile 2008 arasında değişmektedir. Dönemin sanat anlayışına uygun bir şekilde bezemelerle süslenen mezar taşlarının bölgenin tarihi geçmişi, idari ve sosyal durumu hakkında birçok bilgiyi içerdiği görülmüştür. Bu açıdan kültürel ve sanatsal özelliklerinin yanı sıra Bandırma tarihine de ışık tutacak nitelikte oldukları anlaşılmıştır.
INVESTIGATING PRINTABILITY AND MECHANICAL PERFORMANCE OF 3D PRINTED RECYCLED PET WITH PLA AND TPU HYBRID ADDITIVES
Authors: ÇAVA Kutay , ASLAN Mustafa
Published: August 2023

This paper investigates the printability and mechanical performance of 3D printed recycled PET (rPET) filaments with the incorporation of PLA and TPU blend additives. The study focuses on evaluating the tensile, flexural, and impact properties of the resulting hybrid blends. Tensile testing revealed that the neat rPET specimens exhibited average maximum tensile strength of 51.4 MPa and a tensile elasticity modulus of 3.63 GPa. The addition of PLA and TPU additives slightly reduced the tensile strength and modulus. Regarding flexural properties, the rPET specimens demonstrated an average maximum flexural stress of 43.4 MPa, indicating their ability to withstand bending forces without significant deformation. The addition of the hybrid PLA and TPU additives led to a slight reduction in flexural performance. However, the specimens still exhibited acceptable flexural strength and modulus. Furthermore, the impact test results showed a significant improvement in impact strength for the hybrid blend, with the TPU/PLA (rPET blend) exhibiting a remarkable increase (%187 and 36%) compared to the commercial and neat rPET specimens, respectively. These findings suggest that the hybrid combination of PLA and TPU additives contributes to the microstructural integrity and printability of 3D printed objects made from recycled PET filaments, thereby contributing to the advancement of sustainable manufacturing practices.
Food System Strategic Assessment 2023
Authors: LTD Camrosh
Published: August 2023

This Strategic Assessment has been informed by an extensive expert elicitation exercise as well as a literature review. It is intended to support strategic decision-making and anticipatory policy design. Information up to early March 2023 has been used in this assessment with the majority of expert elicitation carried out during January and February 2023. The perceived magnitude and timeline of impact for identified issues was found to be overwhelmingly shaped by the currently increased uncertainties of global and UK political issues, such as the war in Ukraine, the roles of Russia and China in global trade, the consequences of Brexit, and the impact of resulting current global and UK economic pressures. Hence, the majority of identified issues presented in this strategic assessment were perceived as challenges to the food system of increasing urgency at this point in time (March 2023) with mostly short- and medium-term impacts (present to two years, and up to five years respectively).
Analisis Tugas Pokok Pembimbingan Klien Pemasyarakatan (BAPAS) dalam Mewujudkan Reintegrasi Sosial
Authors: Riyadi Riyadi
Published: August 2023

Guidance is a series of law enforcement in the community which is carried out through efforts to restore the unity of life and livelihood relationships of correctional clients so that they can realize their mistakes, improve themselves and not repeat criminal acts and can be accepted back by the community. This article uses a qualitative literature research approach, in which researchers test theories by analyzing data sources derived from literature studies. The results showed that the guidance of correctional clients is carried out by improving the quality, devotion to God Almighty, intellectual, attitudes and behavior, professional, physical and spiritual health of correctional clients. The role of the Correctional Center in particular is to provide guidance to Correctional clients as stipulated in Government Regulation Number 31 of 1999 concerning Guidance and Guidance of Prisoners. To realize Social Integration, it is necessary to analyze the main tasks comprehensively about the main responsibility of guiding correctional clients.
Analisa Putusan International Center for Settlement of Investment Dispute terhadap Perkara No. ARB/12/14 dan ARB/12/40 dapat meningkatkan Imunitas Negara Indonesia sebagai Host Country
Authors: Pasaribu Friska
Published: August 2023

Hak imunitas adalah hak istimewa suatu negara untuk melindungi dan menjalankan fungsi dan kewenangannya. Untuk menjaga kekebalannya terhadap investor asing, Indonesia mengeluarkan Undang-Undang Nomor 30 Tahun 1999 tentang Arbitrase dan Alternatif Penyelesaian Sengketa. Badan arbitrase diupayakan untuk dapat menjadi alternatif yang adil dan menyelenggarakan segala aspek dan substansi hukum yang meliputi arbitrase nasional dan internasional. Dapat disimpulkan bahwa Indonesia sebagai host country memiliki imunitas. Penelitian ini menggunakan metode normatif dan deskriptif analitis dengan menganalisis putusan melalui studi kepustakaan dengan mengumpulkan data primer dan sekunder secara kualitatif. Hasil penelitian menunjukkan bahwa kekebalan Indonesia secara implisit diakui oleh arbitrase International Center for Settlement of Investment Dispute (ICSID). Hal ini terlihat dalam kasus sengketa di Churchill Mining Plc. dan Planet Mining Pty. Ltd. Kasus ini didasari atas tindakan Bupati Kutai Timur yang mencabut Izin Usaha Pertambangan. Tindakan negara ini dikategorikan sebagai jure imperii yang dilegitimasi karena pemerintah Indonesia tidak melakukan pengingkaran keadilan, menurut Tribunal ICSID. Keistimewaan pemerintah Indonesia ini membuktikan bahwa ia memiliki kedaulatan teritorial sendiri sehingga sebagai negara tuan rumah telah mengikuti prinsip yang adil dalam mengelola pertambangan dan penanaman modal asing.
The Effect of Organizational Justice on Desire to Change Jobs: Organizational Citizenship Behavior (OCB) as a Variable
Authors: Setiawan Muhammad Afif , Palupi Majang
Published: August 2023

Human resource management is an important task that must be performed on an ongoing basis. Part of the reason is that human resources are fundamental to driving business growth. This study aims to examine and analyze the effect of organizational justice on the desire to change jobs mediated by Organizational Citizenship Behavior (OCB). The study was conducted on employees of a manufacturing company located in Cikarang, Bekasi Regency with a total sample of 59 respondents. Data was collected by distributing questionnaires with a Likert Scale of 1-6. Data analysis using quantitative method PLS-SEM (Partial Least Square-Structural Equation Modeling) with the help of Smart PLS software. The results showed that procedural justice had a negative and significant effect on the desire to change jobs. Interactional justice has a positive and significant effect on the desire to change jobs. Distributive justice and procedural justice both have a positive and significant effect on OCB, but not on interactional justice which shows a positive and insignificant effect on OCB. OCB has a negative and significant effect on the desire to change jobs. OCB also proved unable to mediate the relationship of the three dimensions of organizational justice (distributive justice, procedural justice and interactional justice) to the desire to change jobs.