bluuebunny/crossref_metadata_2025 huggingface dataset:
DOSE-DEPENDENT EFFECTS OF LEVOTHYROXINE IN HEART FAILURE IN PATIENTS WITH CONCOMITANT THYROID PATHOLOGY
Authors: Pyvovar Sergii , Rudyk Yurii , Lozik Tetiana
Published: November 2021

Abstract. Currently, the use of thyroid hormones in the setting of heart failure (HF) is still an "open book". There are several unanswered questions: the regimen, doses and schedule of drug use, as well as the consequences of such therapy. Large clinical studies can provide information on the effect of these hormones on the long-term prognosis in patients with heart failure. At the same time, the presence of comorbid thyroid pathology, which requires the prescription of levothyroxine (LT), makes it possible to partially answer these questions. The aim is to study of the dose-dependent effect of LT on the course of HF in patients with autoimmune thyroiditis (AIT). Material and methods. The study included 218 patients with HF on the background of post-infarction cardiosclerosis. 109 (50.0 %) patients with AIT received LT due to hypothyreosis in the past. These patients intake LT during 2 years before included in the study and have euthyreosis. Whether the levels of thyroid stimulating hormone (TSH), free triiodthyronine (FT3) and free thyroxine (FT4) were determined. Results. Patients who used LT, comparing with patients without this drug, had smaller end-diastolic diametr (EDD) and end-systolic diametr (ESD) and end-diastolic volum (EDV) and end-systolic volum (ESV) of left ventricle (LV) and 22.9 % greater LV ejection fraction (EF) (+ 22.9 %, p = 0.0001), as well as higher low serum N-terminal prohormone of brain natriuretic peptide (NT-proBNP) level (- 26.3 %, p = 0.009). In the subgroup of patients taking LT at a dose of 0.1 to 0.69 μg/kg, ejection fraction of left ventricle (LVEF) did not differ from patients without this tritment. At a dose of 0.7-1.19 μg/kg, LVEF is higher compared with that of patients who did not take LT (+ 37.9 %, p = 0.0001) and patients who took LT at a dose 0.1 - 0.33 μg/kg (+ 36.9 %, p = 0.0001). LVEF was the highest in patients taking LT at a dose of > 1.20 μg/kg. The use of LT for 2 years reduces the risk of re-hospitalization (RH) due to decompensation of heart failure (Odds ratio = 0.490 (0.281-0.857), p = 0.018) and a tendentious decrease in the risk of combined endpiont achieving (- 27.9 %, p = 0.074). The ROC analysis showed that the risk of RH in patients with heart failure due to decompensation of the disease decreases with the use of LT at a dose of > 0.53 μg/kg (sensitivity – 56.62 %, specificity – 60.98 %, p = 0.016). Conclusions. The use of LT in patients has a dose-dependent positive effect on LVEF. The largest LVEF is observed in patients taking the drug at a dose of > 1.2 μg/kg. The use of an LT dose of > 0.53 μg/kg leads to a significant decrease in the frequency of re-hospitalization due to decompensation of heart failure during 2 years.

Keywords: heart failure, autoimmune thyroiditis, levothyroxine, left ventricular, ejection fraction.
PREVALENCE OF MARKERS OF SARS-COV-2 INFECTION AMONG RESIDENTS OF KYIV REGION AT THE BEGINNING OF THE COVID-19 EPIDEMIC – FIRST RESULTS IN UKRAINE
Authors: Zadorozhna Viktoriia , Sergeyeva Tetiana , Maksymenok Olena , Protas Sviatoslav , Hrynchuk Galyna , Rodyna Nataliia
Published: November 2021

The aim was to determine the seroprevalence of COVID-19, including among healthcare workers and to identify behavioral risk factors.
Materials & methods. During June 10 – July 2, 2020, a population cross-sectional study of COVID-19 seroprevalence was carried out in two districts of the Kiev region. Serum samples from 918 subjects were tested. Participants from the general population and health care workers randomly selected. IgG antibodies to SARS-CoV-2 detected by method of ELISA. Demographic and behavioral information collected via an anonymous questionnaire.
Results. Antibodies to SARS-CoV-2 were detected in 59 subjects (6.43 %, 95 % CI 6.39-6.49). Seroprevalence was higher among healthcare workers (16.67, 95 % CI 16.28–17.06) compared to the general population (3.83 %, 95 % CI 3.78–3.88). More than a third of seropositive individuals (39.29 %, 95 % CI 39.27-39.31) did not report any symptoms. Seropositivity in the general population was associated with age 50–59 years (odds ratio [OR] 2.53, 95 % CI 1.14–5.60), acute respiratory viral infections (ARVI) (OR 3.28, 95 % CI 1, 53-7.05) and their symptoms (OR 6.35, 95 % CI 2.0–20.21), attendance church holidays (OR 8.87, 95 % CI 3.26–24.15). Significant risk factors for medical workers were age 20–29 years (OR 4.53, 95 % CI 1.38–14.91), ARVI (OR 12.9, 95 % CI 5.3–31.0), unknown the number of persons from close communication (OR 2.7, 95 % CI 1.1–6.5), non-compliance with self-isolation (OR 7.5, 95 % CI 2.6–21.5).
Conclusions. At the time of the survey, most individuals did not have antibodies of the IgG class to SARS-CoV-2. Seropositivity data may reflect the proportion of the population that had mild illness, did not seek medical attention, and did not receive testing, but may have contributed to active transmission of the virus. As the COVID-19 pandemic continues and vaccine coverage is far from adequate, there is a need for further high-quality sero-epidemiological studies.
Keywords: antibodies, general population, healthcare workers, SARS-CoV-2, seroprevalence, risk factors.
ONCOLOGICAL EFFECTS OF THE CHORNOBYL DISASTER IN THE REMOTE 35-YEAR POST-ACCIDENT PERIOD
Authors: Bazyka Dimitry , Prysyazhnyuk Anatolii
Published: November 2021

Studies conducted in Ukraine on the long-term oncological consequences of the Chornobyl disaster indicate a significant impact of radiation after an emergency exposure on the incidence of malignant neoplasms of the affected population. This is evidenced by the increased radiation risk of leukemia in liquidators, which exceeds the national population level and its value is comparable to the data on atomic bomb survivors. For the first time in this cohort the radiation dependence of chronic lymphoid leukemia was established. There are radiation risks of leukemia in children exposed to the Chornobyl exposure. There is an increase in the incidence of thyroid cancer not only in children but also in adults: liquidators, evacuated from 30-km zones and inhabitants of areas contaminated with radionuclides. There is an excess of breast cancer in women-liquidators. The incidence of all forms of malignancy compared to national rates decreases over time, but still exceeds them. It is expected that further monitoring of malignant neoplasms in the groups of victims will allow to quantify the radiation risks of already known from previous studies of forms of cancer and those whose radiation-associated manifestation can be expected in the future.
Key words: Chornobyl catastrophe, victims, malignant neoplasms, leukemia, breast cancer, thyroid cancer.
PREPARATION OF CATALASE CROSS-LINKED ENZYME AGGREGATES ON THE BASE OF VATERITE MATRIX
Authors: Eremeev N.L. , Balabushevich N.G. , Volodkin D. , Klyachko N.L.
Published: November 2021

A procedure has been developed for the synthesis of cross-linking aggregates of catalase by treatment with glutaraldehyde incorporated into the pores of the vaterite matrix and subsequent dissolution of the inorganic core. The resulting aggregates have a spherical shape with a narrow particle size distribution and a high specific activity of the enzyme.
THERMOHELIOX INFLUENCE ON THE PROTEOMIC COMPOSITION OF EXHALED BREATH CONDENSATE
Authors: Shogenova L.V. , Kononikhin A.S. , Kozyr A.S. , Panin A.A. , Varfolomeev S.D. , Chuchalin A.G.
Published: November 2021

The proteome of exhaled breath condensate was analyzed by mass spectrometry before, immediately after the thermoheliox procedure and after a 3 h relaxation. The major part of the proteome remained unchanged and there was no extensive cell destruction
COMPUTATIONAL TECHNOLOGY FOR NON-INVASIVE DIAGNOSIS OF CORONARY ARTERY STENOSIS
IN PATIENTS WITH ISCHEMIC HEART DISEASE
Authors: Gamilov T.M. , Simakov S.S. , Kopytov G.V. , Kopylov P.Y. , Gognieva D.G.
Published: November 2021

A digital technology for assessing the fractional flow reserve, a key diagnostic characteristic of coronary artery stenosis, has been developed and validated. The technology has a sufficiently high level of accuracy and can be used in real clinical practice in order to increase the diagnostic efficiency of routine computed tomography of the coronary arteries.
INTERACTIONS OF ANTICANCER DRUGS – ABIRATERONE AND GALETERONE – WITH CYTOCHROME P450 51A1 (CYP51A1)
Authors: Kuzikov A.V. , Veselovsky A.V. , Toropygin I.Yu. , Archakov A.I. , Shumyantseva V.V.
Published: November 2021

Interactions of abiraterone and galeterone with steroid-metabolizing cytochrome P450 (CYP51A1) was studied. Binding of substrate type was observed, which indicates possible metabolism of abiraterone and galeterone by CYP51A1, however electrocatalytic reaction only towards abiraterone was observed.
THE POSSIBILITIES OF ARTIFICIAL INTELLIGENCE IN THE REMOTE ASSESSMENT OF THE PARAMETERS OF THE CARDIOVASCULAR SYSTEM
Authors: Sagirova Zh. , Kuznetsova N. , Zakharov I. , Suvorov A. , Larionov V. , Kopylov Ph.
Published: November 2021

When using a single-channel ECG and FPG, it was possible to assess systolic and diastolic dysfunction of the left ventricle of various degrees with high accuracy
AN UNUSUAL SYSTEM BASED ON SULFUR-CONTAINING AMINO ACIDS AND SILVER SALTS: FROM SELF-ORGANIZATION TO APPLICATION PROSPECTS
Authors: Vishnevetskii D.V. , Mekhtiev A. R. , Khizhnyak S.D. , Pakhomov P.M.
Published: November 2021

Reversible hydrogels containing silver nanoparticles stabilized by the amino acid L-cysteine in their volume were obtained. The silver salt that initiates gelation - nitrite, nitrate and acetate - affects the bioactive properties of the final material and various possibilities for its modification.
SUPERCRITICAL EXTRACTION FOR THE ISOLATION OF BIOLOGICALLY ACTIVE SUBSTANCES
Authors: Kazeev I.V. , Khudeev I.I. , Bocharova O.A.
Published: November 2021

The paper presents the developing direction of supercritical extraction (SCE), which opens up new prospects for the extraction of biologically active substances from plant raw materials. Research is underway to obtain active biological substances for the treatment of socially significant diseases.
DESIGN OF A NEW ETHYLENE PLANT HORMONE SENSOR BASED ON GENOME-WIDE DATA ANALYSIS OF EIN3 TRANSCRIPTION FACTOR BINDING
Authors: Levitsky V.G. , Oshchepkov D.Y. , Zemlyanskaya E.
Published: November 2021

A new structural variant of the transcription factor EIN3 binding site has been obtained. This structural variant is strongly associated with the transcriptional response to ethylene and is preferred for EIN3 binding. Based on this structural variant, a new genetic ethylene sensor was developed.
INVESTIGATION OF BIORESORBABLE COMPOSITE MATERIALS BASED ON POLYLACTIDE, POLYHYDROXYBUTYRATE AND TRICALCIUM PHOSPHATE
Authors: Zimina A.I. , Zhukova P.A. , Senatov F.S.
Published: November 2021

Composite materials based on polylactide, polyhydroxybutyrate and tricalcium phosphate have been developed for the reconstruction of unloaded bone defects.
BIOACTIVE BIOPLASTIC MATERIAL BASED ON ION-TRACK WOUND COATINGS AND CHITOSAN NANO-SCAFFOLD
Authors: Nechaev A. , Eremin P. , Gilmutdinova I.
Published: November 2021

The paper presents the results of the development of a bioactive bioplastic material (BIO) based on ion-track wound coatings (ITRP) and a nano-scaffold of chitosan obtained by electroforming. The water and gas permeability, the ultimate strength, bacteriostaticity, cytotoxicity and biocompatibility of BIO ITPR were investigated.
VIROME OF GRAPEVINE GENETIC COLLECTIONS
Authors: Vinogradova S.V.
Published: November 2021

Russian vineyards are an underexplored reservoir of viral genetic diversity. The use of metagenomics methods allows to obtain information about the virome of a plant and can be used to establish the etiology of a new disease.
APPROACHES FOR IMPROVING SENSITIVITY OF RAPID IMMUNOCHROMATOGRAPHIC TEST SYSTEMS
Authors: Dzantiev B.B.
Published: November 2021

Various nanodispersed markers and their combinations for immunochromatography with colorimetric and fluorimetric detection are considered and their opportunities for lowering the detection limit are characterized. The influence of the composition of antibody-nanomarker conjugates on analytical parameters of the test systems is described.
ELECTROCHEMICAL ACETYLCHOLINESTERASE SENSORS BASED ON CARBON NANOMAERIALS FOR THE DETERMINATION OF DRUGS AND INSECTICIDES
Authors: Shamagsumova R.V.
Published: November 2021

Operational and analytical characteristics of electrochemical biosensors based on acetylcholinesterase have been considered for the determination of enzyme inhibitors. As was shown, application of the mixtures of carbon nanomaterials increases sensitivity of determination over that of single component coatings. Biosensors were tested on determination of reversible inhibitors in urea and blood serum.
HIGHLY SENSITIVE METHODS FOR MICRORNA DETECTION USING ISOTHERMAL METHODS FOR NUCLEIC ACIDS AMPLIFICATION
Authors: Bodulev O.L. , Soloviev A.M.
Published: November 2021

This work will present the results of the development of two new highly sensitive heterogeneous methods for the determination of miRNA-141 and miRNA-39 using the isothermal circular strand-displacement amplification and the catalytic hairpin assembly methods for analyte amplification.
GAP-ENHANCED RAMAN TAGS FOR ANALITICAL AND BIOIMAGING APPLICATIONS
Authors: Khanadeev V.A. , Burov A.M. , Khlebtsov N.G.
Published: November 2021

We discuss recent progress in the synthesis, design of optical properties, analytical and bioimaging applications of novel gap-enhanced Raman tags.
BIOSYNTHESIS OF BUTYRIC ACID FROM GLUCOSE THROUGH THE INVERTED FATTY ACID BETA-OXIDATION PATHWAY BY RECOMBINANT ESCHERICHIA COLI STRAIN IN BIOCATALYTIC MODE DUE TO ENFORCED ATP HYDROLYSIS
Authors: Skorokhodova A.Yu. , Debabov V.G.
Published: November 2021

The feasibility of the application of enforced ATP hydrolysis to ensure anaerobic functioning of Escherichia coli strain producing butyric acid through the inverted fatty acid beta-oxidation pathway as a full-cell biocatalyst has been demonstrated.
ENZYMES AS TARGETS FOR THE EFFECTS OF ORGANOPHOSPHORUS COMPOUNDS AND THEIR BIOCATALYTIC DETOXIFIERS: A NEW LOOK AT A WELL-KNOWN PROBLEM
Authors: Aslanli A.G. , Lyagin I.V.
Published: November 2021

The conducted studies made it possible to identify new targets in the form of the most important decarboxylases for the possible negative effects of known organophosphorus compounds and to assess their potential danger to humans.
ANTIMICROBIAL FILM COATING BASED ON ENZYMATICALLY SYNTHESIZED POLYANILINE DOPED WITH COPPER IONS
Authors: Khlupova M.E. , Shumakovich G.P. , Zaitseva E.A. , Gromova E.V. , Morozova O.V.
Published: November 2021

Enzymatic synthesis of polyaniline (PANI) doped with bivalent copper ions was carried out on a sodium polystyrene sulfonate (PSS) template. The synthesized interpolymer complex PANI-Cu2+/PSS had an inhibitory effect on the growth of Staphylococcus aureus and Escherichia coli cells.
ISOLATION OF MICROMYCETES, POTENTIAL LIGNIN DESTRUCTORS, FROM WOOD PROCESSING ENTERPRISES WASTE
Authors: Ivasenko D.A. , Plotnikov E.V. , Frank Yu.A.
Published: November 2021

Fungal isolates were obtained from the dumps of a wood processing enterprise. Their physiology was studied, and partial species identification was carried out in the ITS region.
CONSORTIA OF THERMOTOLERANT OIL-OXIDIZING MICROORGANISMS CAPABLE OF EFFICIENTLY DECOMPOSING OIL
Authors: Faizulina E.R. , Aitkeldiyeva S.А. , Tatarkina L.G. , Baimakhanova B.G. , Spankulova G.A.
Published: November 2021

The ability of consortia of thermotolerant oil-oxidizing microorganisms to utilize oil at elevated temperatures has been studied. At 35°C the degree of oil destruction was 55-87.3%, at 40°C - 54.8-64.3%, at 50°C - 55-73.2%.
DEVELOPMENT OF THE TECHNOLOGY FOR BIOCONVERSION OF WASTE ACTIVATED SLUDGE FROM AN URBAN WASTEWATER TREATMENT PLANT
Authors: Perchenko R.V. , Bukhtiyarova P.A. , Tyschenko N.V. , Ivasenko D.А.
Published: November 2021

Pilot tests of the composting of waste activated sludge in an urban wastewater treatment plant with a consortium of thermophilic and thermotolerant bacteria has been carried out. The most effective was the bioconversion of activated sludge together with pine sawdust in a ratio of 1:1 or 1:2 using forced aeration of the mixture (0.35 m3/min).
MICROSCOPIC ANALYSIS OF THE STRUCTURE AND COMPONENT COMPOSITION OF THE HUMAN UMBILICAL CORD TISSUE ENGINEERING SCAFFOLD AS THE BASIS OF WOUND COATING
Authors: Kalyuzhnaya L.I. , Sokolova M.O. , Chernov V.E.
Published: November 2021

The composition and structure of the human umbilical cord tissue engineering scaffold were evaluated by microscopic analysis. The preservation of the components and the microstructure that determine the regenerative properties of the cell-free bioscaffold are revealed.
MODIFICATION OF THE SOLID-PHASE METHOD FOR THE SYNTHESIS OF MEDICAL DIOPSIDE FROM MATERIALS OF BIOLOGICAL ORIGIN
Authors: Senatov F.S. , Choudhary R. , Kolesnikov E.A.
Published: November 2021

A modified method for synthesis of diopside for biological applications from biowaste was developed.
MAGNETIC MIP TETRACYCLINE NANOPARTICLES – SYNTHESIS AND APPLICATION IN PIEZOELECTRIC SENSORS
Authors: Bizina E.V. , Ermolaeva T.N.
Published: November 2021

Magnetic polymers with tetracycline molecular imprints have been synthesized. The conditions for the formation of a recognition layer of a piezoelectric sensor based on Fe3O4@MIP particles have been studied. It is shown that the use of the developed nanomaterial makes it possible to reduce the time required to prepare the sensor for analysis by 25 times in comparison with traditional methods.
BIOMIMETIC MATERIALS BASED ON POLYHYDROXYBUTYRATE FOR RECONSTRUCTIVE SURGERY
Authors: F.S. Senatov
Published: November 2021

A biomimetic composite material based on polyhydroxybutyrate with the addition of hydroxyapatite has been developed. The resulting material mimics native human trabecular bone tissue in terms of structure and mechanical properties, and is also bioresorbable and bioactive, which is confirmed by in vitro and in vivo studies.
EARLY BEHAVIORAL DISORDERS IN RATS UNDER THE INFLUENCE OF CHRONIC PRENATAL STRESS
Authors: Zorkina Ya.A. , Zubkov E.A. , Ushakova V.M. , Morozova A.Yu.
Published: November 2021

Prenatal stress induced by exposure to variable ultrasound has been demonstrated to induce anxious behavior and change social preferences in the rat offspring at juvenile age.
Two new species of Polyptychus Hübner, [1819] (Lepidoptera: Sphingidae: Smerinthinae) from West Africa
Authors: Takano Hitoshi
Published: November 2021

Two new species of Polyptychus, Polyptychus smithi sp. nov. and Polyptychus lucindae sp. nov., are described from West Africa. A comparison is made with their closest congeners, Polyptychus coryndoni Rothschild & Jordan, 1903 and Polyptychus lagnelae Pierre, 2014 respectively from which they differ in features of the wing pattern, genitalia and the COI-5P region of the mitochondrial DNA. Diagnoses are provided together with illustrations of the habitus and male genital morphology.
Plataforma Agroclimática Cafetera agroclima.cenicafe.org
Authors: Hincapié-Velásquez Kevin Adolfo , Orozco-Jaramillo Daniel , Álvarez Monsalve Luz Adriana , Benavides Machado Pablo , Marín López Sandra Milena , García-López Juan Carlos
Published: November 2021

La plataforma agroclimática cafetera es una iniciativa de Cenicafé, que ha monitoreado el clima de la zona cafetera de Colombia durante los últimos 70 años. Esta plataforma es una herramienta básica de apoyo para el Servicio de Extensión, investigadores y caficultores, en la toma de decisiones sobre el manejo del cultivo del café. En este Avance Técnico se presentan las funcionalidades y servicios de la Plataforma Agroclimática Cafetera, agroclima.cenicafé.org.
Reconozca las arvenses nobles en el cultivo del café
Authors: Salazar-Gutiérrez Luis Fernando
Published: November 2021

Un problema frecuente que enfrenta el caficultor para establecer las arvenses nobles en su cultivo consiste en que la información para identificarlas en el campo es escasa.

Las arvenses nobles también son conocidas como las arvenses escogidas o seleccionadas y como plantas benéficas que deben utilizarse con el fin de ocupar el espacio de arvenses de mayor interferencia, conservar el suelo y disminuir los costos de las desyerbas . Estas se adaptan a las condiciones ambientales de su medio y tienen la capacidad de sustituir a las arvenses de interferencia alta y media, si se permite su crecimiento en el cultivo.

Favorecer el establecimiento de arvenses nobles es la práctica preventiva de la erosión, que ofrece mayor eficiencia y factibilidad económica y puede obtenerse a través de la implementación del Manejo Integrado de Arvenses . En la mayoría de las áreas cultivadas con café es posible encontrar más de una arvense noble, las cuales deben seleccionarse para favorecer su establecimiento en los sistemas productivos.
Reconozca y favorezca el establecimiento de arvenses nobles en su cultivo de café. Identifique cuáles de ellas están presentes en su finca e implemente el manejo integrado de arvenses, esto le permitirá ser más productivo, rentable y sostenible.
Vulnerabilidad de la caficultura de Boyacá a la broca del café en diferentes eventos climáticos
Authors: Giraldo-Jaramillo Marisol , Montoya Esther Cecilia , Sarmiento-Herrera Ninibeth , Quiroga Mosquera Audberto , Espinosa-Osorio Juan Camilo , García-López Juan Carlos , Duque Orrego Hernando , Benavides Machado Pablo
Published: November 2021

Conocer la vulnerabilidad de una zona a la broca de café, teniendo claro que es una condición natural de esta y que, bajo ciertos escenarios climáticos, la plaga puede comportarse de una forma esperada, es una ventaja competitiva clara para los caficultores, pues podrán anticipar muchas decisiones de manejo. En este Avance Técnico consulte la vulnerabilidad del departamento de Boyacá a la broca del café en diferentes escenarios climáticos, Neutro, La Niña y El Niño.
Diagnóstico de las cochinillas de las raíces del café en ocho departamentos cafeteros de Colombia
Authors: Gil-Palacio Zulma , Caballero Alejandro , Ramos Andrea Amalia , Arcila-Moreno Aníbal , Benavides Machado Pablo
Published: November 2021

Las cochinillas de las raíces del café o “palomillas” como son llamadas comúnmente, son insectos de hábitos fitófagos, que se alimentan de plantas tanto silvestres como cultivadas. En café, su importancia radica en los daños que causan a la planta cuando se alimentan de ella; con su aparato bucal picador-chupador succionan la savia y como consecuencia ocasionan clorosis, defoliación y en algunos casos muerte, especialmente en plantaciones menores a dos años de edad.
htof: A New Open-source Tool for Analyzing Hipparcos, Gaia, and Future Astrometric Missions
Authors: Brandt G. Mirek , Michalik Daniel , Brandt Timothy D. , Li Yiting , Dupuy Trent J. , Zeng Yunlin
Published: November 2021

We present htof, an open-source tool for interpreting and fitting the intermediate astrometric data (IAD) from both the 1997 and 2007 reductions of Hipparcos, the scanning law of Gaia, and future missions such as the Nancy Grace Roman Space Telescope (NGRST). htof solves the astrometric parameters of any system for any arbitrary combination of absolute astrometric missions. In preparation for later Gaia data releases, htof supports arbitrarily high-order astrometric solutions (e.g., five-, seven-, and nine-parameter fits). Using htof, we find that the IAD of 6617 sources in Hipparcos 2007 might have been affected by a data corruption issue. htof integrates an ad hoc correction that reconciles the IAD of these sources with their published catalog solutions. We developed htof to study masses and orbital parameters of substellar companions, and we outline its implementation in one orbit fitting code (orvara). We use htof to predict a range of hypothetical additional planets in the β Pic system, which could be detected by coupling NGRST astrometry with Gaia and Hipparcos. htof is pip installable and available at https://github.com/gmbrandt/htof.
Energetic Particles Associated with a Coronal Mass Ejection Shock Interacting with a Convected Magnetic Structure
Authors: Giacalone J. , Burgess D. , Bale S. D. , Desai M. I. , Mitchell J. G. , Lario D. , Chen C. H. K. , Christian E. R. , de Nolfo G. A. , Hill M. E. , Matthaeus W. H. , McComas D. J. , McNutt R. L. , Mitchell D. G. , Roelof E. C. , Schwadron N. A. , Getachew Tibebu , Joyce C. J.
Published: November 2021

On 2020 November 30, Parker Solar Probe (PSP) was crossed by a coronal mass ejection (CME)-driven shock, which we suggest was also crossing a convected, isolated magnetic structure (MS) at about the same time. By analyzing PSP/FIELDS magnetic field measurements, we find that the leading edge of the MS coincided with the crossing of the shock, while its trailing edge, identified as a crossing of a current sheet, overtook PSP about 7 minutes later. Prior to the arrival of the shock, the flux of 30 keV–3 MeV ions and electrons, as measured by PSP/Integrated Science Investigation of the Sun (ISOIS)/Energetic Particle Instrument (EPI-Lo), increased gradually, peaking at the time of the shock passage. However, during the crossing of the MS downstream of the shock, the energetic-ion flux dropped dramatically, before recovering at about the time of the crossing of the trailing edge of the MS. Afterwards, the ion fluxes remained approximately constant within the sheath region of the CME shock. We interpret this depletion of energetic ions within the MS as the result of insufficient time to accelerate particles at the shock within the MS, given that the structure moves along the shock surface owing to its advection with the solar wind. We present results from a quantitative numerical model of the interaction of an idealized MS with a shock, which supports this interpretation.
Evidence for Gravitational Lensing of GRB 200716C
Authors: Yang Xing , Lü Hou-Jun , Yuan Hao-Yu , Rice Jared , Zhang Zhao , Zhang Bin-Bin , Liang En-Wei
Published: November 2021

Observationally, there is a small fraction of gamma-ray bursts (GRBs) with prompt emission observed by Fermi/GBM that are composed of two pulses. Occasionally, the distance to a GRB may be lensed when a high mass astrophysical object resides in the path between the GRB source and observer. In this paper, we describe GRB 200716C, which has a two-pulse emission and duration of a few seconds. We present a Bayesian analysis identifying gravitational lensing in both temporal and spectral properties, and calculate the time delay (Δt ∼ 1.92 s) and magnification (γ ∼ 1.5) between those two pulses based on the temporal fits. One can roughly estimate the lens mass to be about 2.4 × 105
M
⊙ in the rest frame. We also calculate the false alarm probability for this detection to be about 0.07% with trial factors, and a present-day number density of about 808Mpc−3 with an energy density Ω ∼ 1.4 × 10−3. If the first pulse of this GRB near the trigger time is indeed gravitationally echoed by a second pulse, GRB 200716C may be a short GRB candidate with extended emission.
White-light Continuum Observation of the Off-limb Loops of the SOL2017-09-10 X8.2 Flare: Temporal and Spatial Variations
Authors: Zhao Junwei , Liu Wei , Vial Jean-Claude
Published: November 2021

Observations of the Sun’s off-limb white-light (WL) flares offer rare opportunities to study the energy release and transport mechanisms in flare loops. One of the best such events was SOL2017-09-10, an X8.2 flare that occurred near the Sun’s west limb on 2017 September 10 and produced a WL loop system lasting more than 60 minutes and reaching an altitude higher than 30 Mm. The event was well observed by a suite of ground- and space-based instruments, including the Solar Dynamics Observatory/Helioseismic and Magnetic Imager (SDO/HMI) that captured its off-limb loops in WL continuum near Fe i 6173 Å, and the Atmospheric Imager Assembly (SDO/AIA) that observed its ultraviolet (UV) and extreme-ultraviolet (EUV) counterparts. We found quasi-periodic pulsations in the WL and UV emissions at the flare loop-top with a period around 8.0 minutes. Each pulsation appears to have an EUV counterpart that occurs earlier in time and higher in altitude. Despite many similarities in the WL and UV images and light curves, the WL flux at the loop-top continues to grow for about 16 minutes while the UV fluxes gradually decay. We discuss the implication of these unprecedented observations on the understanding of the enigmatic off-limb WL flare emission mechanisms.
Case Study Analysis: The Utilization of Health Services by Citizens at Area of Tangerang Selatan, Indonesia
Authors: Permatasari Putri , Arbitera Cahya , Wenny Dwi Mutia
Published: November 2021

BACKGROUND: Citizens are people who have a high risk of exposure to diseases due to unhealthy environmental conditions. This requires citizens to take advantage of health services in order to get optimal examinations.

AIM: The purpose of this study was to determine the description and relationship between the characteristics of citizens, the characteristics of health services and the utilization of health services by citizens in the area of Tangerang Selatan, Indonesia in 2020.

METHODS: The quantitative research method with cross-sectional design used random sampling techniques. The number of samples was 150 families in the area of Tangerang Selatan, Indonesia. The riset measured data using a questionnaire and collected data by interviewing the respondents. Data analysis used Chi-square analysis and multiple logistic regression analysis.

RESULTS: The results showed that the variables related to the utilization of health services were knowledge variable (p = 0.001), number of families (p = 0.021), perception of pain (p = 0.001), and family support (p = 0.030). And the variables that were not related to the utilization of health services were ownership of health insurance (p = 0.750), transportation (p = 0.297), distance (0.340), health information (p = 0.538), and attitudes of health workers (p = 1000). As well as the dominant variable related to the utilization of health services, that is knowledge (p = 0.000) with odds ratio 12.876.

CONCLUSION: It is hope that primary healthcare and health workers can involve more communities around the area in their work programs, such as providing health information.
Lilium shenxianjui (Liliaceae), a new species from central Zhejiang, East China
Authors: Xu Yue-Liang , Zhu Zhi-Ming , Yi-Fei Lu
Published: November 2021

Lilium shenxianjui Y.L.Xu & Y.F.Lu, a new species of Liliaceae from Zhejiang, East China, is described with illustrations. The new species is morphologically similar to L. concolor and L. bakerianum in having campanulate flowers and converging stamens, but differs from the former in having stems dark purple (vs. green, rarely base purple), leaf blades densely papillose at margin and abaxial mid-ribs (vs. glabrous), pedicle base with 2 bracts (vs. solitary), flowers red-orange, 4–10 in a short raceme (vs. dark red, 1–5 in a raceme or sub-umbel), tepals 4.8–6 cm long, 0.8–1.5 cm wide (vs. 2.2–4 cm long, 4–7 mm wide), nectars glabrous at margin (vs. papillose at margin), anthers lunate, ca. 1 cm long (vs. long-oblong, ca. 7 mm long), styles ±2 as long as ovaries (vs. slightly shorter). It differs from Lilium bakerianum in having pedicle base with 2 bracts (vs. solitary), flowers 4–10, red-orange, unspotted (vs. flowers 1–3, white, purple-red spotted), tepals 4.8–6 cm long, 0.8–1.5 cm wide (vs. 6.5–8 cm long, 1.4–2.3 cm wide), ovaries 8–10 mm long (vs. 1.7–2 cm long).
Spiradiclis detianensis (Rubiaceae, Ophiorrhizeae), a new species from southwestern Guangxi, China
Authors: Wen Zhao-Jie , Huang Yun-Fen , Hu Yan-Hua , Nguyen Khang Sinh , Wu Lei
Published: November 2021

A new species of Rubiaceae, Spiradiclis detianensis is described from a limestone karst area of southwestern China. This new species is morphologically similar to S. cordata and S. spathulata. All of them have rosetted habit and long peduncles, but it differs from the former by the cuneate leaf bases (vs. basally cordate) and much longer corolla tubes (1.8–2.2 cm long vs. ca. 5 mm long), and from the latter mainly by its tubular-funnel shaped corolla (vs. slenderly salver shaped), 4.5–6.8 (vs. 1.5–2) mm in diam, inside throat and corolla densely puberulent (vs. glabrous except a ring of long hairs at the middle). It also resembles to S. tubiflora, but differs clearly by its subrosulate habit (vs. procumbent to creeping), longer leaf blades (7.0–10.5 cm vs. 0.5–2.5 cm) and longer corolla tubes (18–22 mm vs. 14–16 mm). At same time, color photos, illustrations, detailed descriptions and conservation status of the new species are provided.
Robust uniform persistence for structured models of delay differential equations
Authors: Salceanu Paul L.
Published: November 2021

We consider a general class of delay differential equations systems, typically used to model the dynamics of structured biological populations, and establish necessary conditions for the part of the attractor contained in the boundary of the state space to repel the complementary dynamics contained in the interior of the state space. The conditions are formulated in terms of Lyapunov exponents and invariant probability measures and we use them to prove a robust uniform persistence result.
Analysis of a model of the Calvin cycle with diffusion of ATP
Authors: Gürbüz Burcu , Rendall Alan D.
Published: November 2021

The dynamics of a mathematical model of the Calvin cycle, which is part of photosynthesis, is analysed. Since diffusion of ATP is included in the model a system of reaction-diffusion equations is obtained. It is proved that for a suitable choice of parameters there exist spatially inhomogeneous positive steady states, in fact infinitely many of them. It is also shown that all positive steady states, homogeneous and inhomogeneous, are nonlinearly unstable. The only smooth steady state which could be stable is a trivial one, where all concentrations except that of ATP are zero. It is found that in the spatially homogeneous case there are steady states with the property that the linearization about that state has eigenvalues which are not real, indicating the presence of oscillations. Numerical simulations exhibit solutions for which the concentrations are not monotone functions of time.
The fragmentation equation with size diffusion: Small and large size behavior of stationary solutions
Authors: Laurençot Philippe , Walker Christoph
Published: November 2021

The small and large size behavior of stationary solutions to the fragmentation equation with size diffusion is investigated. It is shown that these solutions behave like stretched exponentials for large sizes, the exponent in the exponential being solely given by the behavior of the overall fragmentation rate at infinity. In contrast, the small size behavior is partially governed by the daughter fragmentation distribution and is at most linear, with possibly non-algebraic behavior. Explicit solutions are also provided for particular fragmentation coefficients.
H-infinity bipartite consensus of multi-agent systems with external disturbance and probabilistic actuator faults in signed networks
Authors: Li Hongjie ,   College of Data Science, Jiaxing University, Zhejiang 314001, China
Published: November 2021

The H-infinity bipartite consensus problem is addressed for a class of linear multi-agent systems with external disturbance, where the positive and negative links are allowed in communication topology. A novel event-triggered communication scheme is presented to save limited network resources, which dependents on information from neighboring agents at event-triggered instants, the given event-triggered condition is detected only at discrete sampling times, thus Zeno behavior can be excluded, two types of event-triggered matrices have been introduced in our event-triggered communication scheme, which can further reduce the sampled-data transmission compared with some existed results. Considering the probabilistic actuator faults, the reliable controller is designed based on sampled-data, then a new distribution-based fault model is constructed by using coordinate transform. Some H-infinity bipartite consensus criteria can be derived by the Lyapunov stability theory and algebraic graph theory, at the same time, the feedback matrices and event-triggered matrices can be obtained by solving some linear matrix inequalities. Finally, a numerical example is employed to show the validity and advantage of the proposed transmission scheme.
A novel 10-gene immune-related lncRNA signature model for the prognosis of colorectal cancer
Authors: Ma Bin ,   Department of Colorectal Surgery, Liaoning Cancer Hospital & Institute (Cancer Hospital of China Medical University), Shenyang, China, Cao Lianqun , Li Yongmin
Published: November 2021

Background

The tumor immune microenvironment of colorectal cancer (CRC) affects tumor development, prognosis and immunotherapy strategies. Recently, immune-related lncRNA were shown to play vital roles in the tumor immune microenvironment. The objective of this study was to identify lncRNAs involved in the immune response, tumorigenesis and progression of CRC and to establish an immune-related lncRNA signature for predicting the prognosis of CRC.

Methods

We used data retrieved from the cancer genome atlas (TCGA) dataset to construct a 10-gene immune-related lncRNA pair (IRLP) signature model using a method based on the ranking and comparison of paired gene expression in CRC. The clinical prognosis, immune checkpoints and lncRNA-protein networks were analyzed to evaluate the signature.

Results

The signature was closely associated with overall survival of CRC patients (p < 0.001 in both of the training and validating cohorts) and the 3-year AUC values for the training and validating cohorts were 0.884 and 0.739, respectively. And, there were positive correlations between the signature and age (p = 0.048), clinical stage (p < 0.01), T stage (p < 0.01), N stage (p < 0.001) and M stage (p < 0.01). In addition, the signature model appeared to be highly relevant to some checkpoints, including CD160, TNFSF15, HHLA2, IDO2 and KIR3DL1. Further, molecular functional analysis and lncRNA-protein networks were applied to understand the molecular mechanisms underlying the carcinogenic effect and progression.

Conclusion

The 10-gene IRLP signature model is an independent prognostic factor for CRC patient and can be utilized for the development of immunotherapy.
A mathematical model for human-to-human transmission of COVID-19: a case study for Turkey's data
Authors: Cengizci Süleyman ,   Computer Programming, Antalya Bilim University, Antalya 07190, Turkey, Cengizci Aslıhan Dursun , Uğur Ömür ,   Institute of Applied Mathematics, Middle East Technical University, Ankara 06800, Turkey,   Faculty of Tourism, Antalya Bilim University, Antalya 07190, Turkey
Published: November 2021

In this study, a mathematical model for simulating the human-to-human transmission of the novel coronavirus disease (COVID-19) is presented for Turkey's data. For this purpose, the total population is classified into eight epidemiological compartments, including the super-spreaders. The local stability and sensitivity analysis in terms of the model parameters are discussed, and the basic reproduction number, $ R_{0} $, is derived. The system of nonlinear ordinary differential equations is solved by using the Galerkin finite element method in the FEniCS environment. Furthermore, to guide the interested reader in reproducing the results and/or performing their own simulations, a sample solver is provided. Numerical simulations show that the proposed model is quite convenient for Turkey's data when used with appropriate parameters.
Juventudes e práticas do documentário em São Paulo: ativismo cultural e políticas de visibilidade
Authors: Almendary Livia Chede , Borelli Silvia Helena Simões
Published: November 2021

A centralidade das imagens na contemporaneidade, as relações de poder em torno delas, a imagem como mediação cognitiva e a ampliação e democratização de suas formas de produção impactam a construção de materialidades audiovisuais, entre elas o documentário. Há um universo crescente de práticas independentes de realização de documentários, forjadas por diferentes processos de produção e difusão, uso das tecnologias digitais e relações específicas com a política, as lutas sociais e os engajamentos. Coletivos juvenis na cidade de São Paulo, vinculados a contextos periféricos e subalternizados, apropriam-se da cultura audiovisual e do documentário como estratégias de visibilidade, resistências e reexistências. Constituem a metodologia e o marco teórico do artigo observações cotidianas, entrevistas em profundidade e análises fundamentadas nos Estudos Culturais – assim como suas reverberações latino-americanas e outras referências dos campos da Comunicação e da Antropologia, com foco em juventudes.
Analysis of Security-Based Access Control Models for Cloud Computing
Authors: Choudhary Sandeep , Singh Nanhay
Published: November 2021

Access control has become the most necessary requirement to limit unauthorized and privileged access to information systems in cloud computing. Access control models counter the additional security challenges like rules, domain names, job allocation, multi hosting and separation of tasks. This paper classifies the conventional and modern access control models which has been utilized to restrain these access flaws by employing a variety of practices and methodologies. It examine the frequent security threats to information confidentiality, integrity, data accessibility and their approach used for cloud solutions. This paper proposed a priority based task scheduling access control (PbTAC) model to secure and scheduled access of resources & services rendered to cloud user. PbTAC model will ensure the job allocation, tasks scheduling and security of information through its rule policies during transmission between parties. It also help in reducing system overhead by minimize the computation and less storage cost.
Fuzzy Multi-Objective Portfolio Optimization Considering Investment Return and Investment Risk
Authors: Srizongkhram Shayarath , Suthamanondh Pisacha , Manitayakul Kittitath , Shirahada Kunio , Chiadamrong Navee
Published: November 2021

Portfolio selection and optimization deal with the selection of the most suitable projects in a portfolio. The expected goals can be achieved while considering the balance among selected projects, to ensure that all selected projects consume resources effectively. This study proposes and compares multi-objective portfolio investment optimization algorithms under uncertain conditions. The investment return (in terms of the fuzzy net present value of the portfolio) and investment risk (in terms of the credibilistic risk index) have simultaneously been considered. In addition, fuzzy chance-constrained programming is introduced as an optimization constraint to handle such uncertainty by specifying a desired confidence level of the decision makers. The outcome of this study can then help decision makers to decide what projects and when to invest. Decision makers can deal with a limited budget with logical relationships, and within their desired financial and risk requirements.
Assessing the Risks and Success Factors of Telehealth Development Projects in an Academic Setting
Authors: Kilinc Mehmet Serdar
Published: November 2021

The development of a telehealth technology in an academic setting is a complex project that faces several obstacles. The early assessment of the project risks plays a critical role in the translation of promising telehealth innovations into healthcare practice. This paper presents a decision support tool based on Failure Mode and Effects Analysis (FMEA) and Quality Function Deployment (QFD) techniques to associate the project risks to relevant success factors. Certain modiﬁcations in both techniques are applied to deploy them for project risk assessment. The project risks and success factors used in the tool are identified from the literature. The proposed decision support tool enables researchers to manage the risks in their telehealth development projects and identify action items to overcome such risks. The application of the proposed tool is illustrated with a telehealth development project for virtual physical therapy.
Optimization-Based Tuberculosis Image Segmentation by Ant Colony Heuristic Method
Authors: Priya E.
Published: November 2021

Tuberculosis (TB) is a worldwide health crisis and is the second primary infectious disease that causes death next to human immunodeficiency virus. In this work, an attempt has been made to detect the presence of bacilli in sputum smears. The smear images recorded under standard image acquisition protocol are subjected to hybrid Ant Colony Optimization (ACO)-morphological based segmentation procedure. This method is able to retain the shape of bacilli in TB images. The segmented images are validated with ground truth using overlap, distance and probability-based measures. Significant shape-based features such as area, perimeter, compactness, shape factor and tortuosity are extracted from the segmented images. It is observed that this method preserves more edges, detects the presence of bacilli and facilitates direct segmentation with reduced number of redundant searches to generate edges. Thus this hybrid segmentation technique aid in the diagnostic relevance of TB images in identifying the objects present in them.
A Case Study of the Effectiveness of Online Graduate Teacher Education in TESOL
Authors: Adamy Peter , Correia Amy , Byrd David
Published: November 2021

A cadre of school teachers took part in three semesters of online coursework to earn TESOL certification. They participated in a hybrid university math course and a face-to-face summer institute on effective teaching of math to English learners. Participants took pre and post-tests aligned to Common Core elementary mathematics content and the Praxis Test for Teachers of English to Speakers of Other Languages. They were observed teaching a math lesson in the beginning of the project to evaluate effectiveness in TESOL instructional strategies. A follow up observation was conducted the following semester. Both observations were scored using the sheltered instruction observation protocol (SIOP Model). Assessment and observation results indicated statistically significant growth in content and pedagogical knowledge and application. A qualitative analysis suggests flexibility in the form of online and hybrid courses, financial support, and practical application of new concepts to current practice are key factors in successful professional development for practicing teachers.
Factors associated with cesarean delivery in adult nulliparous women
Authors: Willemann Maria Cristina Antunes , Nicolotti Célia Adriana , Baratieri Tatiane , Kupek Emil
Published: November 2021

The aim of this study was to analyze the sociodemographic factors associated with cesarean section in adult women with conditions favorable for normal delivery and to identify the groups most likely to undergo this surgery in the state of Santa Catarina (SC). A case control study with microdata from the Sistema de Informação de Nascidos Vivos on 7,065 women for 2016 in SC. A relationship between cesarean section and sociodemographic variables was analyzed by logistic regression where we calculated the Adjusted Odds Ratio (AOR), confidence interval and p-value. The probability of cesarean section for each group of women (called "interaction") was also calculated. Among women with more favorable conditions for normal childbirth, the prevalence of cesarean section was 41.1%. Lower chance of cesarean section was found for women without partners (AOR: 0.79 [0.71-0.87]), up to 8 years of schooling (AOR: 0.56 [0.47-0.66]), with up to 2 prenatal visits (AOR: 0.46 [0.23-0.90]). The most likely group of women (51.4% [49.3-53.4]) to undergo cesarean section are women who perform 7 to 15 prenatal visits and have 12 or more years of schooling. A cesarean section occurs with women who have greater access to education and prenatal care and those who have partners, even though the aspects favor normal childbirth, suggesting that this does not seem to be a decision only by women.