bluuebunny/crossref_metadata_2025 huggingface dataset:
Examination of the APOBEC3 Barrier to Cross Species Transmission of Primate Lentiviruses
Authors: Gaba Amit , Flath Ben , Chelico Linda
Published: June 2021

The transmission of viruses from animal hosts into humans have led to the emergence of several diseases. Usually these cross-species transmissions are blocked by host restriction factors, which are proteins that can block virus replication at a specific step. In the natural virus host, the restriction factor activity is usually suppressed by a viral antagonist protein, but this is not the case for restriction factors from an unnatural host. However, due to ongoing viral evolution, sometimes the viral antagonist can evolve to suppress restriction factors in a new host, enabling cross-species transmission. Here we examine the classical case of this paradigm by reviewing research on APOBEC3 restriction factors and how they can suppress human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV). APOBEC3 enzymes are single-stranded DNA cytidine deaminases that can induce mutagenesis of proviral DNA by catalyzing the conversion of cytidine to promutagenic uridine on single-stranded viral (−)DNA if they escape the HIV/SIV antagonist protein, Vif. APOBEC3 degradation is induced by Vif through the proteasome pathway. SIV has been transmitted between Old World Monkeys and to hominids. Here we examine the adaptations that enabled such events and the ongoing impact of the APOBEC3-Vif interface on HIV in humans.
Phytochemical Characterization of Olea europea Leaf Extracts and Assessment of Their Anti-Microbial and Anti-HSV-1 Activity
Authors: Ben-Amor Ichrak , Musarra-Pizzo Maria , Smeriglio Antonella , D’Arrigo Manuela , Pennisi Rosamaria , Attia Hammadi , Gargouri Bochra , Trombetta Domenico , Mandalari Giuseppina , Sciortino Maria Teresa
Published: June 2021

Owing to the richness of bioactive compounds, Olea europea leaf extracts exhibit a range of health effects. The present research evaluated the antibacterial and antiviral effect of leaf extracts obtained from Olea europea L. var. sativa (OESA) and Olea europea var. sylvestris (OESY) from Tunisia. LC-DAD-ESI-MS analysis allowed the identification of different compounds that contributed to the observed biological properties. Both OESA and OESY were active against Gram-positive bacteria (MIC values between 7.81 and 15.61 μg/mL and between 15.61 and 31.25 μg/mL against Staphylococcus aureus ATCC 6538 for OESY and OESA, respectively). The antiviral activity against the herpes simplex type 1 (HSV-1) was assessed on Vero cells. The results of cell viability indicated that Olea europea leaf extracts were not toxic to cultured Vero cells. The half maximal cytotoxic concentration (CC50) values for OESA and OESY were 0.2 mg/mL and 0.82 mg/mL, respectively. Furthermore, both a plaque reduction assay and viral entry assay were used to demonstrate the antiviral activity. In conclusion, Olea europea leaf extracts demonstrated a bacteriostatic effect, as well as remarkable antiviral activity, which could provide an alternative treatment against resistant strains.
Effects of Lactobacillus rhamnosus and Enterococcus faecalis Supplementation as Direct-Fed Microbials on Rumen Microbiota of Boer and Speckled Goat Breeds
Authors: Maake Takalani Whitney , Aiyegoro Olayinka Ayobami , Adeleke Matthew Adekunle
Published: June 2021

The effects on rumen microbial communities of direct-fed probiotics, Lactobacillus rhamnosus and Enterococcus faecalis, singly and in combination as feed supplements to both the Boer and Speckled goats were studied using the Illumina Miseq platform targeting the V3-V4 region of the 16S rRNA microbial genes from sampled rumen fluid. Thirty-six goats of both the Boer and Speckled were divided into five experimental groups: (T1) = diet + Lactobacillus rhamnosus; (T2) = diet + Enterococcus faecalis; (T3) = diet + Lactobacillus rhamnosus + Enterococcus faecalis; (T4, positive control) = diet + antibiotic and (T5, negative control) = diet without antibiotics and without probiotics. Our results revealed that Bacteroidetes, Firmicutes, TM7, Proteobacteria, and Euryarchaeota dominate the bacterial communities. In our observations, Lactobacillus rhamnosus and Enterococcus faecalis supplements reduced the archaeal population of Methanomassiliicocca in the T1, T2 and T3 groups, and caused an increase in the T4 group. Chlamydiae were present only in the T5 group, suggesting that probiotic and antibiotic inhibit the growth of pathogens in the rumen. We inferred, based on our results, that Lactobacillus rhamnosus and Enterococcus faecalis favour the survival of beneficial microbial communities in the goats’ rumen. This may lead to an overall improved feed efficacy and growth rate.
Stream Network Modeling Using Remote Sensing Data in an Alpine Cold Catchment
Authors: Cao Hong , Pan Zhao , Chang Qixin , Zhou Aiguo , Wang Xu , Sun Ziyong
Published: June 2021

The hydrological information derived from a digital elevation model is very important in distributed hydrological modeling. As part of alpine hydrological research on stream network modeling using remote sensing data in the northeast of the Tibetan Plateau, three digital elevation model (DEM) datasets were obtained for the purpose of hydrological features, mainly including channel network, watershed extent and terrain character. The data sources include the airborne light detection and ranging (LiDAR) with point spacing of 1 m, the High Mountain Asia (HMA) DEM and the Shuttle Radar Topography Mission (SRTM) DEM. Mapping of the watershed and stream network was conducted using each of the three DEM datasets. The modeled stream networks using the different DEMs were verified against the actual network mapped in the field. The results show that the stream network derived from the LiDAR DEM was the most accurate representation of the network mapped in the field. The SRTM DEM overestimated the basin hypsometry relative to the LiDAR watershed at the lowest elevation, while the HMA DEM underestimated the basin hypsometry relative to the LiDAR watershed at the highest elevation. This may be because, compared with the SRTM DEM and the HMA DEM, the LiDAR DEM has higher initial point density, accuracy and resolution. It can be seen that the LiDAR data have great potential for the application in hydrologic modeling and water resource management in small alpine catchments.
3-D Numerical Study of a Bottom Ramp Fish Passage Using Smoothed Particle Hydrodynamics
Authors: Novak Gorazd , Domínguez José M. , Tafuni Angelo , Silva Ana T. , Pengal Polona , Četina Matjaž , Žagar Dušan
Published: June 2021

Worldwide, the overwhelming number of man-made barriers in fluvial systems has been identified as one of the major causes of the reported staggering average declines of migratory fish. Fish passages have been shown to help mitigate such problems. Close-to-nature types of fish passages, such as bottom ramps, bypass channels, and fish ramps can be used to minimize the impact of artificial steep drops (e.g., weirs) on the migration of aquatic fauna, especially in cases of low-head barriers. This study focuses on the characterization of the flow pattern in a bottom ramp. A 3-D numerical model based on the meshless smoothed particle hydrodynamics (SPH) method was successfully validated and then employed for the simulation of turbulent free-surface flow in a straight channel with complex geometry. The effects of bed roughness, channel slope, and flow rate were quantified in terms of flow depth, velocity fields, and area‒velocity ratios. During the study, several new tools were developed, leading to new functionalities in pre-processing, solver, and post-processing which increase the applicability of DualSPHysics in the field of eco-hydraulics.
An Overview of the Numerical Approaches to Water Hammer Modelling: The Ongoing Quest for Practical and Accurate Numerical Approaches
Authors: Pal Susovan , Hanmaiahgari Prashanth Reddy , Karney Bryan W.
Published: June 2021

Here, recent developments in the key numerical approaches to water hammer modelling are summarized and critiqued. This paper summarizes one-dimensional modelling using the finite difference method (FDM), the method of characteristics (MOC), and especially the more recent finite volume method (FVM). The discussion is briefly extended to two-dimensional modelling, as well as to computational fluid dynamics (CFD) approaches. Finite volume methods are of particular note, since they approximate the governing partial differential equations (PDEs) in a volume integral form, thus intrinsically conserving mass and momentum fluxes. Accuracy in transient modelling is particularly important in certain (typically more nuanced) applications, including fault (leakage and blockage) detection. The FVM, first advanced using Godunov’s scheme, is preferred in cases where wave celerity evolves over time (e.g., due to the release of air) or due to spatial changes (e.g., due to changes in wall thickness). Both numerical and experimental studies demonstrate that the first-order Godunov’s scheme compares favourably with the MOC in terms of accuracy and computational speed; with further advances in the FVM schemes, it progressively achieves faster and more accurate codes. The current range of numerical methods is discussed and illustrated, including highlighting both their limitations and their advantages.
Fluvial Geomorphology and River Management
Authors: Giano Salvatore Ivo
Published: June 2021

This Special Issue deals with the role of fluvial geomorphology in landscape evolution and the impact of human activities on fluvial systems, which require river restoration and management [...]
Economic and biological characteristics and quality of production of rabbits of different origin
Authors: Chaunina E. A. , Karabanova L. V. , Karmatskikh Yu. A.
Published: June 2021

Rabbit as one of the species of farm animals has a number of advantages: precocity, prolificacy, low expenditures on housing and feeding, high payback of feed production. The purpose of the research was to study the economic and biological characteristics and product quality of rabbits of different origin. Comprehensive research has been carried out under the environments of LLC “ACRO” in the Omsk region. Four experimental groups have been formed for research: the 1st group included animals four purebred females and one purebred male of White Giant breed; the 2nd group included four purebred females and one purebred male of California breed; the 3rd group included four purebred females of White Giant breed and one purebred male of California breed; the 4st group included four purebred females of California breed and one purebred male of White Giant breed. The maximum level of profitability of rabbit production has been obtained in the group of animals obtained from direct crossbreeding of White Giant and California breeds – 22,7 % (the 3rd group). This figure was higher by 9,6 % then in the group’s purebred animals of breed White Giant (the 1st group), 4,6 % then in group of animals obtained from the backcrossing breeds of California and White Giant (the 4st group) and 3,2 % then in group of purebred animal of the breed of California (2nd group). It has been found as a result of the conducted research that crossbreds obtained from direct crossbreeding of White Giant and California breeds have been superior to purebred herdmates of White Giant and California breeds, as well as animals obtained from backcrossing of California and White Giant breeds in terms of growth rate, formation characteristics, slaughter indicators and economic efficiency of rabbit production.
State anti-virus policy: educational chinese practice
Authors: Novoselova Liubov
Published: June 2021

The rapid deterioration of the epidemiological situation at the beginning of 2020 required a broad system of response measures from the Chinese state, including a number of strict quarantine measures, which caused widespread disruption of economic life. This system, which includes measures to counteract such economic excesses, was the subject of the article. Describing the content and course of the relevant Chinese policy, as well as its results, the author of the article shows the following.

Trying to stop the economic decline and return it to sustainable development, the PRC leadership first of all stepped up its fiscal and monetary policy. There was a decrease in the tax burden on manufacturers, a decrease in the required reserves and interest rates on loans. In order to further stimulate investment activity, the quotas for the issuance of targeted bond loans by local governments for the development of infrastructure and healthcare were increased.

These and other measures have borne fruit. The immediate result was a significant increase in the total public financing of the economy in 2020. And at the end of the year, China turned out to be the only large country with positive economic dynamics, further strengthening its position in the world economy
From the history of the soviet political economy of socialism: «the Stalin trap»
Authors: Lyubinin Alexander
Published: June 2021

The article is devoted to the influence on the evolution of the Soviet political economy of the statement of I.V. Stalin, which appeared in 1936, about the implementation in the USSR of «basically the first phase of communism-socialism». This formulation became canonical and was not questioned throughout the Soviet period. Reacting to the apparent inconsistencies of socio-economic practice with classical Marxist ideas about socialism, some political economists went out of criticism of Marxism, leaning towards essentially non-Marxist interpretations of socialism in general and Soviet socialism in particular. Other scholars have sought ways to reconcile Soviet reality with the Marxist classics by improving the former, while remaining convinced that the USSR is a completely socialist country.

Why did this Stalinist formula appear and was sincerely accepted, including for theoretical reasons, by the scientific community? In what historical and methodological plane could the problem of a completely Marxist interpretation of Soviet socialism be adequately resolved? The answers to these questions are offered by the author of the article.
Mutations in two neuroblastoma rat sarcoma oncogenes are associated with progression of haematologic malignancies in Nigeria
Authors: Anyanwu Nneoma Confidence JeanStephanie , Suleiman Ahmed Babangida , Ella Elijah Ekah , Kazeem Haruna Makanjuola , Aminu Maryam
Published: June 2021

Although mutation in the RAS genes has become important in the evaluation of haematologic malignancies worldwide, developing countries like Nigeria are yet to integrate it as a diagnostic tool and prognostic indicator for improved therapy. This study determined mutations in codons 12 and 13 of NRAS gene in blood donors and haematologic malignant individuals using multiplex (AS-PCR) and Sanger sequencing, thus highlighting the mutations as helpful diagnostic and prognostic tool. AS-PCR was used to selectively amplify mutation-specific synthetic oligonucleotides from the cfDNA of 100 study participants (50 cancer patients and 50 blood donors). Percentage mutation of 31.0% was seen in NRAS_G12D gene while NRAS_G13C had 17.0%. Twenty nine (29.0%) of the NRAS_G12D mutations were found in haematopoietic malignant patients and 2.0% were found in blood donors, while 15.0% of the NRAS_G13C were found in the malignant patients, confirming the occurrence of NRAS gene mutations in haematologic cancers and predominance of the G-A transition. The highest rate of mutation was observed in leukaemia patients, having a significant association with codon 13 (p = 0.042). Stages 3 and 2 cancers each had the highest mutation rates of NRAS_G12D and NRAS_G13C, revealing possible link between these mutations and susceptibility and progression of haematologic malignancies, which is higher in leukaemia. Further NRAS mutation studies and its role in other cancers are advocated, especially targeted towards ameliorating diagnosis and prognostic therapy. Challenges related to diagnosis and management of haematologic cancer continue to persist in developing countries like Nigeria. Thus, there is a need to go beyond studying the incidence and distribution pattern of these malignancies to capturing immunogenetic parameters of affected individuals.
The Analysis of Financial Literacy and Its Impact on Investment Decisions: A Study on Generation Z In Jakarta
Authors: Utami Novia , Sitanggang Marsiana Luciana , Sitanggang Marsiana Luciana
Published: June 2021

The influence of digitalization has extended across industries including the financial sector. Numerous innovations for investment have been launched while financial information has now become easily accessible, raising potential for Generation Z (Gen Z) to make investment. This study aims to understand financial literacy and investment behavior of Gen Z in Jakarta, Indonesia. Data were collected using quantitative approach, particularly through adoption of online questionnaire and convenience sampling technique. The relationship between financial literacy and investment decisions was then analyzed using Structural Equation Model regression - Lisrel statistical software. Finally, it was found that financial literacy significantly influenced investment decisions of Gen Z in Jakarta.
Urena lobata (PEMANFAATAN SEBAGAI OBAT TRADISIONAL DAN BIOAKTIVITASNYA)
Authors: Silalahi Marina
Published: June 2021

Urena lobata  is one of the Malvaceae family that has long been used as medicine. This plant is easy to find on the roadside or empty land because it is one of the pioneering vegetation plants, therefore it is very potential to be developed as traditional medicine. The purpose of writing this article is to explain the relationship between the utilization and bioactivity of U. lobata. The method used in writing this article is a review and review of the literature published online. In ethnobotany, U. Lobata is used for fever, rheumatism, wounds, and as an antiseptic. Urena lobata but prominent bioactivity is antimicrobial, antifertility, anti-diabetes Mellitus, and hepatoprotective. The potential and bioactivity of U. lobata as an antifertility for further investigation so that it can be developed to regulate the number of births and is reversible.
Microbiological and total particles suspended indoor air quality at the Universidad Iberoamericana Torreón
Authors: Martínez-Villalba José Antonio , Luna-Porres Mayra Yudirian , Gilio-Villa Alejandra Mayela , Arredondo-Guerrero Sebastián Jafet
Published: June 2021

Indoor air quality was analyzed in the period from 2016 to 2019, in the Universidad Iberoamericana Torreón, with the objective of determining if it complied with the reference norms: ISO 14644- 1-2015 and UNE 100012:2005; due to in Mexico there are no applicable norms for the monitoring or indication of the Maximum Permissible Limits to determine indoor air quality. Methodology applied was focused on: 1) Determining the PSTs (from 0.3 to 10 µm) using a FLUKE particle counter; 2) Microbiological analysis; 3) Identifying isolated strains and 4) Calculating origin and wind intensity using a METPAK II climatological data and a WRPLOT software. PST and microbiological concentrations were found to be above the standards used. PS0.3 showed a significant difference (p<0.05) in the Auditorium, which had the highest concentrations in 2019 of evening schedule. Some of the biological material were identified as: 1) pathogenic bacteria of the genera Salmonella, Klebisella and Escherichia, and 2) fungi of the genera Aspergillus, Trichophyton and Candida; whose exposure could produce different allergies, asthma, develop respiratory symptoms, chronic cough, laryngitis, sinusitis and urticaria.
ANALISIS DAYA SAING EKONOMI SEKTORAL KABUPATEN OGAN KOMERING ULU SELATAN
Authors: Pandriadi Pandriadi , Ningsih Endang Kusdiah , Novianty Dwi Eka , Mario Asma
Published: June 2021

This research aims to analize the competitveness of economy sectoral of OKU Selatan District based on secondary data from several local institutions. To determine of competitiveness, this research uses Location Qoutient (LQ) Analysis and Classen Tipology. In conclusion, this research shows that based on LQ Analysis and Classen Typology, there are several sectors which has high competitiveness, such as agricultural and manufacturing industry. On the other side this research also shows the sector which has low competitiveness, such as mining and energy.
Social Capital, Migration, and Social Integration
Authors: Thi Mai Le
Published: June 2021

Objective - This paper focuses on exploring the ways in which social capital is utilised to promote the integration of Vietnamese women who married Taiwanese husbands into host families and the host. Methodology/Technique - Data was derived from a case study undertaken in 2014 on the Penghu Islands and in Taipei, Taiwan, with interviews and the observation of 31 people including Vietnamese women who married Taiwanese husbands, local people. Findings - Findings reveal the values and norms of responsibility of Vietnamese women in family that were educated themselves, have been practiced effectively by Vietnamese women married to Taiwanese husbands to integrate into their families. Research limitations/implications - The regulations and legal environment for immigrants have created favourable conditions for their integration into the host families. Traditional Vietnamese cooking skills are chosen by many Vietnamese women as a kind of social capital for their access to the Taiwanese job market. The social integration is reflected through social-economic, culture integration, and citizenship. Originality/value - It is hoped that study results will serve as the useful scientific basis for developing policies that promote the social integration of immigrants for the development of individuals and the social community. Type of Paper - Empirical Keywords: Social Capital; Social Integration; Migration Marriage. JEL Classification: C31, O15
The Model of Public Relations Practices in Indonesia
Authors: Kriyantono Rachmat , Amrullah Abdul Allam , Destrity Nia Asthon
Published: June 2021

Objective - This research aims to compare the government public relations with business public relations in Indonesia. The research proves the hypothesis that either government or business public relations in Indonesia have already applied symmetric model on their communication activities.

Methodology/Technique - A national survey involves 160 practitioners of government and business public relations. The research reinforces Grunig and Hunt's model of public relations that business public relations tends practice two-way symmetrical communication. On the other hands, the research also differs with Grunig and Hunt's model that government public relations tend to apply public information model.

Findings - It is concluded that both government and business public relations in Indonesia have implemented two-way communication models. The findings have confirmed that public relations practices have grown along with the development of democracy in Indonesia.

Novelty - The research contributes to develop scientific knowledge in public relations study and practices.

Type of Paper: Empirical

Keywords: Business Public Relations; Democracy; Government Public Relations; Indonesia; Public Relations Model; Symmetric Model; Transparency of Public Information.

JEL Classification: H11, H83.
Religious Influences on Store Loyalty among Grocery Shoppers in Mauritius: The Mediating Role of Trust
Authors: Carrim Jackaria Nazneen
Published: June 2021

Objective - This paper explores the relationship between consumer religion and store loyalty, to empirically test whether this relationship can be mediated by consumer trust. This study draws its theoretical foundations from literature focused on customers interpersonal relationships with salespeople and customer trust, in particular the study by Sheth (1983) on Shopping Preference Theory.

Methodology/Technique - A randomly selected sample of Mauritian grocery shoppers is used in this study. The data was collected through a telephone interview of 409 grocery shoppers. The final sample consisted of 49.4% Hindus, 17.4% Muslims and 33.2% Catholics, reflecting the religious portion of the Mauritian population.

Findings - The use of regression analysis shows that religious commitment has a significant relationship with store loyalty. When trust is introduced into the model, this significant relationship becomes insignificant, demonstrating how religious commitment strongly influences trust.

Research limitations/implications - The findings are limited to grocery shoppers in Mauritius. Generalisation of the results is achieved by broadening the context of shopping activities examined, for example, to include online shopping for durable and non-durable products. Examining a broader group of religions may also be considered.

Novelty - The mediation model proposed in this study demonstrates the significance of the mediating role of trust in the relationship between consumer religious preferences and their loyalty to shops. To date, this topic has been given little attention at the retail level. These findings address the gap in the religious domain by focusing more significantly on ways to improve store loyalty through the use of trust in the retail setting, in areas where the market is highly religious.

Type of Paper - Empirical

Keywords: Religious Affiliation; Religious Commitment; Store Loyalty; Store Trust.

JEL Classification: M10, Z12
Managing Non-Governmental Organizations to Create Values in the Disruption Era
Authors: Said Laila Refiana
Published: June 2021

Objective - This paper explores the challenges faced by the Indonesia National Council on Social Welfare (INCSW) and its 64 organization members from 31 provinces in Indonesia. INCSW is a social organization that is the coordinating agency for social activities by the Government of Indonesia. The analysis includes strategic management of NGOs in the era of disruption, known as the industrial revolution 4.0.

Methodology/Technique - This study uses a qualitative methodology procedure to produce descriptive data obtained from verbal answers and observable behavior. The data collection methods used in this study include interviews, surveys, observations, and use of documents as secondary data. Open interviews were conducted with several administrators and staff of the Indonesia National Council on Social Welfare (INCSW). Short questionnaires were given to 64 representatives of NGOs from 31 provinces. The interview and survey included questions that probed their understanding of the industrial revolution 4.0, disruptive innovation, willingness to change, and the readiness of the organization to create values in the era of disruption.

Findings - The results show that technology use is still very lacking. The quality of human resources is of minimum concern in digital knowledge. The discussions include observations about the development of management strategies and a variety of programs offered by the Indonesia National Council on Social Welfare (INCSW).

Novelty - This research is one of the few studies that examine non-profit organizations in order to create economic and social values in the era of disruption. This study explains the new paradigm of NGOs by changing the platform of NGO work operationalization. This study widens the application of 'network society' theory in the study of NGOs by emphasizing networks to create value for their stakeholders. The managerial implications of this study include the importance of technology use through social media for social sharing, thus communicating social issues more efficiently and effectively.

Type of Paper - Empirical.

Keywords: Change Management; Disruptive Innovation; Human Resources; Industry Revolution 4.0; Non-Governmental Organizations.

JEL Classification: M20, M21, M29.
Performance Enhanced Coded OFDM with Almost Linear Inter leaver over Rayleigh Fading Channels
Authors: han chenggao
Published: June 2021

This paper presents a comprehensive performance analysis of coded orthogonal frequency division multiplexing (COFDM) over the quasi-static multipath Rayleigh fading channels. We first analyze the pairwise error probability (PEP) of COFDM and then consider the union bound on bit error rate (BER) by introducing the notion of diversity guard (DG) and a novel interleaver class, named almost linear interleaver (ALI). A construction of ALI is also introduced with its parameter selection. Simulation results show that the COFDM with ALI outperforms that with random interleaver (RI) and the block interleaver (BI) adopted in the IEEE industry standards.
Introduzione
Authors: Senatore Francesco
Published: June 2021

The paper introduces the volume, focuses the purposes of the research, summarizes the essays and their historiographical framework. If you study the archives of Southern Italy’s feudal lords, you are studying the nature of seigniorial power and the strategies of the aristocratic memory.
Notiziario
Authors: Bollettino della Società Geografica Italiana Redazione
Published: June 2021

Notizie, relative a eventi di carattere geografico, selezionate a cura della Redazione.
PENGARUH KUALITAS KEFARMASIAN TERHADAP PELAYANAN DI APOTEK RSIA ANANDA TRIFA KOTA PAREPARE
Authors:   ITKES Muhammadiyah Sidrap, Wirastuti Ade , A. Noe Yusri , Rahmawati Rahmawati
Published: June 2021

Pelayanan pada dasarnya dapat dikatakan sebagai suatu tindakan ataupun cara melayani orang lain untuk memenuhi keinginannya. Pelayanan kesehatan merupakan tanggung jawab dari pemerintah, swasta ataupun masyarakat. Apotek adalah salah satu bentuk pelayanan kesehatan masyarakat. Hal utama yang perlu diperhatikan di apotek adalah meningkatkan kualitas pelanggan agar dapat bertahan, bersaing mempertahankan pasar yang ada. Oleh karena itu, apotek harus mempertahankan ataupun meingkatkan kualitasnya dengan memberikan pelayanan yang sesuai. Tujuan penelitian ini adalah untuk mengetahuai kualitas pelayan kefarmasian di Apotek RSIA Ananda Trifa kota parepare. Jenis penelitian ini adalah penelitian deskriptif kuantatif, lokasi penelitian ini dilakukan di Apotek RSIA Ananda Trifa kota Parepare. waktu penelitian bulan 20 Juli s/d 19 Agustus 2019 jumlah sampel sebanyak 100 Responden pengambilan sampel dengan mengunakan teknik purposive sampling, instrument penelitian berupa kuesioner dengan menggunakan cara manual. Hasil penelitian menunjukkan bahwa kualitas pelayanan kefarmasian di Apotek Ananda Trifa Kota Parepare terhadap kepuasan konsumen termasuk dalam kategori puas, dengan persentase masing-masing sebagai berikut, realibility 71,43%, responsiveness 72,00%, assurance 61,08%, emphaty 69,94%, dan tangible 62,39%.
Pelatihan Pemasaran Melalui Media Sosial Dalam Meningkatkan Penjualan Produk UMKM Di PLUT KUMKM Tulungagung
Authors: Nurani Nurani , Eni Widhajati  , Eni minarni  , Mukhamad Eldon
Published: June 2021

Abstract

Micro, Small and Medium Enterprises play an important role in improving the economy and welfare of the community. The ability to compete and market products is one of the spearheads for business actors to exist and be competitive. There are many factors that influence the success of a business, however how a product can dominate the market is one of the priorities that business actors must do. In the era of the Industrial Revolution 4.0, business people can no longer rely on conventional marketing, they must also start marketing their products online. This shift in the marketing model must be carried out immediately by business actors so that their products are able to compete in the global market. In this context, the business actors have been assisted by PLUT KUMKM Tulungagung which  have experienced in solving many problems in terms of marketing,. The purpose of this activity is to provide knowledge about the use of social media as a marketing medium and provide skills to MSME owners in increasing sales of their products. The method used in this activity is training and mentoring. The results of the training and mentoring activities besides increasing knowledge are expected that business actors will also be able to use social media as a means of product promotion and marketing so that sales can increase.

Abstrak

Usaha Mikro Kecil Menengah berperan penting dalam meningkatkan perekonomian dan kesejahteraan masyarakat. Kemampuan bersaing dan pemasaran produk menjadi salah satu ujung tombak agar pelaku usaha dapat eksis dan berdaya saing. Banyak faktor yang mempengaruhi keberhasilan suatu usaha, namun bagaimana  suatu produk dapat menguasai pasar menjadi salah satu prioritas yang harus dilakukan oleh pelaku usaha. Pada era Revolusi Industri 4.0 pelaku usaha tidak dapat lagi mengandalkan pemasaran konvensional, mereka juga harus mulai memasarkan produknya secara online. Pergeseran model pemasaran ini harus segera dilakukan oleh pelaku usaha agar produknya mampu bersaing dipasar global. Pelaku usaha binaan PLUT KUMKM Tulungagung banyak mengalami kendala dalam hal pemasaran, pelaku usaha masih mengandalkan pemasaran konvensional dan belum memanfaatkan media social secara maksimal sebagai sarana pemasaran produknya.

Tujuan kegiatan ini adalah untuk memberikan pengetahuan tentang pemanfaatan media social sebagai media pemasaran dan memberikan ketrampilan kepada pemilik UMKM dalam meningkatkan penjualan produknya. Metode yang digunakan dalam kegiatan ini pelatihan dan pendampingan. Hasil dari kegiatan disamping meningkatkan pengetahuan diharapkan pelaku usaha juga mampu memanfaatkan sosial media sebagai sarana promosi dan pemasaran produk sehingga penjualan dapat meningkat.
Pemeriksaan Tekanan Darah Dan Konseling Tentang Hipertensi dan Komplikasinya Pada Lansia Di Desa Kromasan Kabupaten Tulungagung
Authors: Siti Suciati  , Ernik Rustiana
Published: June 2021

Abstract

The main problem in various countries related to health is heart disease and blood vessels. Hypnosis is one of the first triggers in the world annually. The number of people with hypertension continues to increase every year. It is estimated that in 2025 there will be 1.5 billion people who suffer from hypertension, and it is predicted that 10.44 million people die annually due to hypertension and its complications. Management of hypertension can be done from the knowledge of the elderly about hypertension and hypertension diet regulation. Activities that have been carried out include providing health education related to hypertension, blood pressure checks, being taught progressive muscle relaxation techniques, and being given an understanding of making cucumber juice and starfruit to control hypertension. The purpose of this activity is expected to be an increase in awareness, knowledge, and behavior of the elderly in a healthy life regarding hypertension so that the elderly realizes the importance of maintaining blood pressure experienced at this time. Community service activities in Kromasan Village, NgunutTulungagungSubdistrict were carried out in September 2019. Of the 110 elderly people present, 41 elderly people were found with blood pressure above normal (140-90 mmHg). It can be said that the prevalence of hypertension is only 37.3%, because other elderly people have been controlled by using anti-hypertensive drugs given from the Ngunut Health Center.

Abstrak

Masalah utama di berbagai negara yang berkaitan dengan kesehatan adalah penyakit jantung dan pembuluh darah. Hipetensi merupakan salah satu pemicu pertama di dunia per tahunya. Angka penderita hipertensi terus mengalami peningkatan setiap tahunya. Diperkirakan pada tahun 2025 akan ada 1,5 Miliar orang yang menderita hipertensi, dan diprediksi per tahunnya 10,44 juta orang meninggal yang disebabkan karena hipertensi dan komplikasinya. Manajemen hipertensi dapat dilakukan dari pengetahuan lansia mengenai hipertensi serta pengaturan diet hipertensi. Kegiatan yang telah dilakukan yaitu memberikan pendidikan kesehatan terkait penyakit hipertensi, pemeriksaan tekanan darah, tehnik relaksasi otot progresif, dan diberi pemahaman tentang pembuatan jus timun dan belimbing untuk mengontrol hipertensi. Tujuan dari kegiatan ini diharapakan ada peningkatan kesadaran, pengetahuan, maupun perilaku lansia sehingga menyadari pentingnya menjaga tekanan darah yang dialami saat ini. Kegiatan dilaksanakan pada bulan September 2019. Dari110 lansia yang hadir, ditemukan 41orang lansia dengan tekanan darah diatas normal (140 90mmHg). Hal ini dapat dikatakan prevalensi yang memiliki hipertensi hanya 37,3%, dikarenakan lansia lainnya telah terkontrol dengan menggunakan obat anti hipertensi yang diberikan dari Puskesmas Ngunut.
México ante el dilema del “tercer país seguro” en el contexto de los Protocolos de Protección a Migrantes (MPP)
Authors: Morales-Cardiel Jorge , Vargas Chantal Lucero
Published: June 2021

La implementación de los Protocolos de Protección a Migrantes (MPP), conocido en México como el programa “Quédate en México”, fue una acción del gobierno de Estados Unidos mediante la cual ciertas personas extranjeras que ingresaban o buscaban admisión a dicho país desde México, de forma iregular, podían ser devueltas a este país para esperar la resolución a su solicitud de admisión (asilo). El gobierno de México convino, por razones humanitarias, recibirlos y permitir una estadía en el país durante la vigencia del trámite migratorio legal. Esta situación de reasentamiento convirtió a México en un supuesto “tercer país seguro”, un hecho que de entrada no considera el largo expediente de violaciones de derechos humanos hacia los migrantes en tránsito por territorio mexicano, por consecuencia el presente trabajo presenta una reconceptualización de la migración forzada a raíz de este tipo de acuerdos
РАЗВИТИЕ КУЛЬТУРЫ ОТНОШЕНИЙ У МЛАДШИХ ШКОЛЬНИКОВ
Authors: Минкаилова З.Х. , Булуева Ш.И.
Published: June 2021

В статье автором раскрыт процесс развития культуры отношений у младших школьников в процессе обучения. Развитие культуры отношений на сегодняшний день имеет приоритетное значение в рамках обучения и воспитания подрастающего поколения, так как одной из важных целей становится формирование всесторонне развитой личности. Представлен анализ ФГОС НОО, в котором обоснован «портрет выпускника начальной школы» в соответствии с основной целью духовно-нравственного развития и воспитания личности младшего школьника. Дана психическая характеристика младшего школьного возраста. Дано структурное содержание культуры отношений: культура общения, коммуникативная культура, культура поведения, культура межличностных отношений, культура речи. Культура общения представлена деятельностным, психическим и эмоциональным уровнями. Автором показана роль тьютера в образовательном процессе с нормотипичными обучающимися и учащимися с ОВЗ, при формировании у них культуры отношений.
РАЗВИТИЕ ВОСПРИЯТИЯ ЦВЕТА У ДЕТЕЙ ДОШКОЛЬНОГО ВОЗРАСТА
Authors: Шамилева А.И. , Насурова З.А.
Published: June 2021

Статья посвящена актуальной проблеме формирования цветовосприятия детей дошкольного возраста в художественно-творческой деятельности. Восприятие цвета определяется авторами как процесс осознанного понимания цвета, основными закономерностями которого являются целостность, осмысленность, апперцепция, избирательность и константность. Развитие цветовосприятия является одной из задач теории обучения изобразительной деятельности дошкольников, имеет большое значение не только для развития изобразительных навыков ребенка, но и для общего уровеня его развития (способствует развитию внимания, восприятия, воображения, мышления и памяти, речи, абстрактно-логического мышления). Авторами представлена интерпретация цвета в рисунках детей, показаны приемы работы с цветом; анализ цветового строя в живописи и природе; отмечена необходимость создания особой эстетической среды пространства вокруг детей.
Estilos de liderazgo y responsabilidad social empresarial en productoras sonorenses de uva
Authors: A La Torre Islas Marco Alberto , Robles Parra Jesús Martin , Preciado Rodríguez Juan Martin , Camarena Gómez Beatriz Olivia , De la Rosa Leal María Eugenia
Published: June 2021

El presente artículo evalúa los estilos de liderazgo que han permitido a las organizaciones productoras sonorenses de uva de mesa incorporar la responsabilidad social empresarial (RSE) y avanzar así hacia organizaciones sustentables. El estudio de la RSE se fundamenta en la triple cuenta de resultados, se trata de un diseño transversal descriptivo, que relaciona las variables por agrupación mediante el lenguaje R. Los resultados indican que los liderazgos transformacionales y transaccionales son los que permiten mayores niveles de RSE. Destacan los líderes transaccionales con los puntajes más altos, como refiere la literatura revisada, dado que la RSE está siendo introducida como una exigencia de mercado y no por convicción ética de los empresarios.
Sobre a noção de Situação Didática Olímpica aplicada ao contexto das Olimpíadas Internacionais de Matemática
Authors: Santiago Paulo Vitor da Silva , Vieira Alves Francisco Régis , Pereira Maia Beatriz Maria
Published: June 2021

O presente artigo apresenta uma ordem teórico-conceitual específico de uma estruturação da investigação em Didática da Matemática com a finalidade de mostrar uma discussão e a oportunidade do alcance de conhecimentos didático-metodológicos envolvendo o ensino de Geometria Plana por meio de Problemas Olímpicos obtidos das avaliações da Olimpíada Internacional de Matemática. O objetivo do trabalho é realizar uma Engenharia Didática pretendendo a estruturação de uma Situação Didática Olímpica, com ênfase no ensino de Geometria Plana, com o apoio do softwareeducacional GeoGebra como recurso tecnológico com o propósito de proporcionar a compreensão de novas resoluções aos alunos por meio dos comandos e visualização das figuras expostas na situação-problema didática olímpica. Foi utilizada a metodologia de Michèle Artigue (1988), a Engenharia Didática enumerado nas suas primeiras fases: Análises preliminares e Concepção e Análise a priori da situação didática, com dedicação à concepção e a modelização de figuras planas de uma situação-problema olímpica em acréscimo com a Teoria das Situações Didáticas de Guy Brousseau (1986) e o software educacional GeoGebra como recurso tecnológico colaborando na construção junto aos comandos operacionais e a visualização da figura. Essa proposta tem importância em uma Situação Didática Olímpica para os professores de matemática promover momentos de interação que favoreceram a execução em sala de aula ou na preparação de procedimentos para a Olimpíada Internacional de Matemática, ou seja, para um melhor planejamento e na aprendizagem metodológica aplicada no ambiente escolar.
Sodium Tetra Decyl Sulfate: A Sclerosant To Be Used with Caution
Authors: Singh Indrajeet
Published: June 2021

The treatments of vascular malformations pose extreme challenge not only to the surgeons but to the patients as well. A surgical intervention might be effective for all well circumscribed malformations of moderate size with possibility of attaining anatomic and functional restoration but the surgical approach may lead to tissue damage and massive bleeding. Alternatively, Sclerotherapy gives a good choice for the treatment of vascular malformation. In addition, sclerotherapy is also used to reduce the size of lesion, preoperatively as a support to surgery and even some times post-surgically.
Tomaszewski's Problem on Randomly Signed sums, Revisited
Authors: Boppana Ravi B. , Hendriks Harrie , Van Zuijlen Martien C.A.
Published: June 2021

Let $v_1,v_2,\ldots, v_n$ be real numbers whose squares add up to 1.  Consider the $2^n$ signed sums of the form $S = \sum \pm v_i$.  Boppana and Holzman (2017) proved that at least 13/32 of these sums satisfy $|S| \le 1$.  Here we improve their bound to $0.427685$.
A Medico Legal Study of Fetal Deaths in and Around Guntur
Authors: A.Krishnajaneyulu  , N. Devchand  , Raja Sekhar Uppu  , T.T.K.Reddy
Published: June 2021

Introduction: There are quite a number of foetal deaths occurring in the developing country like India due to low socio economic status, illiteracy, ignorance, lack of interest, concealment of the birth, having female child etc. This is despite the fact that these occurrences are a world- wide phenomenon and by definition involve criminal law concerns such as illegal abortion, concealment of birth, murder, or neonaticide and abandonment of babies. This study is to make comprehensive and analytical study of various medico legal aspects of foetal and infant deaths in and around Guntur district during the period of 2013-2015.Materials and methods: This is a three year retrospective study of autopsies done on the foetus and infants at the Department of Forensic Medicine, GMC/GGH Mortuary, Guntur from 2013 to 2015. Inquest and autopsy findings are analyzed to evaluate demographic profile and various socio-economic factors contributing to the foetal deaths, the pattern of injuries, manner & cause of death of the foetuses, neonates and infants. Observations and conclusion: Total number of cases of foetal autopsy amounts to around 1.2 % of total autopsy during the study period but in the study, relatively large number i.e., 50% of cases of abortuses, foetuses and newborns indicated that the manner had been homicidal or death by abandonment. Female foetal autopsies amounted to about 52% of total foetal autopsies and homicidal male foetal deaths are 56% of total homicidal foetal deaths. This study is helpful to the investigating authorities to identify such cases for further investigation of the cases.
Cross-modal commutativity of magnitude productions of loudness and brightness
Authors: Ellermeier Wolfgang , Kattner Florian , Raum Anika
Published: June 2021

In their fundamental paper, Luce, Steingrimsson, and Narens (2010, Psychological Review, 117, 1247-1258) proposed that ratio productions constituting a generalization of cross-modality matching may be represented on a single scale of subjective intensity, if they meet “cross-dimensional commutativity.” The present experiment is the first to test this axiom by making truly cross-modal adjustments of the type: “Make the sound three times as loud as the light appears bright!” Twenty participants repeatedly adjusted the level of a burst of noise to result in the desired sensation ratio (e.g., to be three times as intense) compared to the brightness emanating from a grayscale square, and vice versa. Cross-modal commutativity was tested by comparing a set of successive ×2×3 productions with a set of ×3×2 productions. When this property was individually evaluated for each of 20 participants and for two possible directions, i.e., starting out with a noise burst or a luminous patch, only seven of the 40 tests indicated a statistically significant violation of cross-modal commutativity. Cross-modal monotonicity, i.e. checking whether ×1, ×2, and ×3 adjustments are strictly ordered, was evaluated on the same data set and found to hold. Multiplicativity, by contrast, i.e., comparing the outcome of a ×1×6 adjustment with ×2×3 sequences, irrespective of order, was violated in 17 of 40 tests, or at least once for all but six participants. This suggests that both loudness and brightness sensations may be measured on a common ratio scale of subjective intensity, but cautions against interpreting the numbers involved at face value.