bluuebunny/crossref_metadata_2025 huggingface dataset:
Untargeted Metabolomic Analyses of Body Fluids to Differentiate
TBI DOC and NTBI DOC
Authors: Xiao Xiaoping , Xu Long , Lu Hezhen , Liu Xiaoyan , Sun Haidan , Guo Zhengguang , Sun Jiameng , Qi Feng , Niu Xia , Wang Aiwei , Ge Qianqian , Zhuang Yutong , Geng Xiaoli , Chen Xueling , Lan Ying , He Jianghong , Sun Wei
Published: October 2023

Objective:

To investigate the metabolomic differences between Traumatic
brain injury (TBI) disorder of consciousness (DOC) patients and non-traumatic brain
injury (NTBI) DOC patients by using cerebrospinal fluid (CSF), serum and urine
samples beneficial to understand the pathological mechanism differences between the
two etiologies, provide potential clues for the subsequent treatment and prognosis, and
investigate the metabolome differences and similarities between TBI and NTBI among
three different body fluids.

Methods:

In total, 24 TBI DOC subjects and 29 NTBI DOC subjects were enrolled.
CSF, serum and urine samples from TBI DOC and NTBI DOC patients were collected
and analyzed by performing UPLC-MS. The statistical methods and pathway analyses
were applied to discover potential biomarkers and altered metabolic functions.

Results:

When comparing TBI DOC and NTBI DOC, 36, 31 and 52 differential
metabolites were obtained in CSF, serum and urine, respectively. The functional
analysis of differential metabolites obtained in CSF, serum and urine were all related to
amino acid metabolism. Except for amino acid metabolism, metabolic biomarkers in
CSF, serum and urine mainly focus on central function, cognitive function, necrosis
and apoptosis and neurological function, respectively. In CSF, the highest AUC was
0.864 (Isoproturon) and 0.816 (Proline betaine). Then, the AUC of NFurfurylformamide
in serum was 0.941, while the AUC of Dihydronepetalactone and
Doxepin N-oxide glucuronide were 1.0 in urine.

Conclusion:

CSF, serum and urine metabolomic analyses could differentiate TBI
DOC from NTBI DOC and functional analyses showed a metabolic change difference
between TBI DOC and NTBI DOC.
Observation on the Effect of Sequentially Combined Multi-modal
Artificial Liver Treatment on HBV-related Acute-on-chronic Liver
Failure
Authors: Zhou Xueshi , Miu Youhan , Guo Xiaoye , Wang Jun , Su Tingting , Du Hejuan , Wang Sen , Zhang Ying , Qiu Yuanwang , Zhao Weifeng
Published: October 2023

Objective:

To observe the short-term effect of sequentially combined multimodal
artificial liver treatment (SCMALT) on HBV-related acute-on-chronic liver failure
(HBV-ACLF).

Methods:

HBV-ACLF patients 155 cases undergoing artificial liver treatment were
analyzed, and they were sorted into the SCMALT group and the conventional-modal
artificial liver treatment (CALT) group. The clinical data of all patients were recorded
and the serum levels of interleukin-8 (IL-8), chemokine interferon-inducible protein-10
(IP-10), and interleukin-6 (IL-6) were detected. The changes in the 30-day survival
rate, cytokine level, model for end-stage liver disease (MELD) score, and
complications of artificial liver treatment were analyzed.

Results:

After being followed up for 30 days, 104 patients survived and 51 died. At the
end of the whole-course treatment, the decreases in IL-6, IP-10, and IL-8 levels and
MELD scores in the SCMALT group were greater than in the CALT group. Cox
regression suggested WBC (OR=1.066, 95% CI 1.012-1.123, P=0.017), AT-III
activity (OR=0.935, 95% CI 0.907-0.964, p=0.000) at baseline, artificial liver
treatment mode (OR=0.362, 95% CI 0.164-0.800, p=0.012), number of artificial liver
treatments (OR=0.656 95% CI 0.436-0.986, p=0.043), spontaneous peritonitis
(OR=0.337, 95% CI 0.165-0.689, p=0.003), and hepatic encephalopathy (OR=0.104,
95% CI 0.028-0.388, p=0.001) were independent influencing factors of 30-day
survival rate. SCMALT can significantly prolong the survival period of the patient. No
obvious difference was shown in the proportions of bleeding and circulation instability
between the two groups (p>0.05).

Conclusion:

Compared with the CALT, SCMALT can more effectively remove
inflammatory mediators and reduce the MELD score in HBV-ACLF patients, which can
obviously ameliorate the prognosis, with less effect on the platelet count.
Targeting the AKT/mTOR/p70S6K Pathway for Oligodendrocyte Differentiation and Myelin Regeneration in Neurological Disorders
Authors: Ge Chen , Li Changwei
Published: October 2023

Background:

The AKT/mTOR/p70S6K pathway has been shown to potentially promote
spinal cord injury (SCI) repair in rats. However, its exact mechanism and beyond needs to
be further explored.

Objective:

This study aims to explore the AKT/mTOR/p70S6K pathway in oligodendrocyte precursor
cell (OPC) differentiation, microglial polarization differentiation, and the role of these in
myelin regeneration in vitro.

Methods:

The isolation, induction and characterization of rat primary neuronal stem cells, OPCs
and oligodendrocytes were investigated with immunofluorescence and RT-qPCR. Then, the role
of AKT/mTOR/p70S6K signaling was explored using western blotting and immunofluorescence,
the effect on myelination was examined with OPC-dorsal root ganglion (DRG) neurons
co-culture, and the influence of M1/M2 polarization status of microglia on myelin formation was
also observed by adding M1/M2 supernatants into OPC-DRG neurons co-culture.

Results:

Activation of the AKT/mTOR/p70S6K pathway elevated the expression of oligodendrocyte
differentiation markers, including MBP, PLP and MOG, which also promoted the colocalization
of MBP and NFH in OPC-DRG neurons co-culture. More interestingly, stimulation
of the AKT/mTOR/p70S6K pathway facilitated M2 polarization of rat microglia. M2 polarization
of microglia enhanced OPC differentiation to oligodendrocytes and myelin formation.

Conclusion:

Our findings highlight the potential of targeting the AKT/mTOR/p70S6K pathway
in promoting oligodendrocyte differentiation and myelin regeneration in neurological disorders
such as SCI.
Method Validation and Monitoring of N-nitrosodimethylamine in Metformin Hydrochloride Products in China by GC-MS/MS
Authors: Zou Jia-jia , Yang Lin , Xu Xiao-li , Li Yan , He Dan
Published: October 2023

Background:

N-nitrosodimethylamine (NDMA) are a sort of genotoxic impurities
(GTIs) having strong carcinogenic effects and obvious hepatotoxicity. To monitor the NDMA
content of metformin hydrochloride sustained-release tablets and enteric capsules in China
from 2018 to 2022, a GC-MS/MS method was established and validated.

Materials and Methods:

The chromatographic column was Agilent VF-WAXms capillary column
(30 m×0.25 mm, 0.25 μm). The GC-MS/MS method was equipped with multiple reaction
monitoring (MRM) modes. To assess the quantity of NDMA, the molecular ion at mass-tocharge
(m/z) of 74-44 was monitored under the 6 V collision energy, and to assess the quality
of NDMA monitoring, the molecular ions at m/z 74-42 were determined. A total of 143 batches
of metformin hydrochloride-finished products from 35 enterprises were determined by
this method

Results:

The linear range of the method was 0.25 ~ 50.00 ng/mL, r = 0.9998, S/N > 10, and the
limit of detection and quantitation were 0.06 ng/mL and 0.21 ng/mL, respectively. The average
recovery was 98.62%, and the RSD was 4.31%. All batches of enteric capsules met the requirements;
38.21% of the 123 batches sustained-release tablets still exceeded the acceptable daily
intake.

Conclusion:

The presented method is sensitive, accurate, precise, and available for both enteric
capsules and sustained-release tablets of metformin hydrochloride, which can provide a reference
for their quality control. The over-limit phenomenon of NDMA in metformin hydrochloride
products poses new challenges and requirements for both the State Drug Administration
and enterprises.
Impact of Mesenchymal Stem Cells on the Gut Microbiota and Microbiota
Associated Functions in Inflammatory Bowel Disease: A Systematic
Review of Preclinical Evidence on Animal Models
Authors: Liu Airu , Li Chenyang , Wang Chen , Liang Xiaonan , Zhang Xiaolan
Published: October 2023

Background:

Inflammatory bowel disease (IBD) is a global health problem in which
gut microbiota dysbiosis plays a pivotal pathogenic role. Mesenchymal stem cells (MSCs) therapy
has shown promising application prospects for its powerful immune regulation and tissue repair
ability. Recent experimental data suggest that MSCs also regulate the composition of gut microbiota.
The current review analyzed, for the first time, the research data linking MSCs and gut microbiota
modulation in IBD models aiming at assessing the role of gut microbiota in MSCs repair
of IBD.

Methods:

A comprehensive and structured literature search was performed up to January 2023 on
the PubMed, Web of Science, and Scopus databases. The quality and risk of bias assessment followed
the PRISMA guidelines and SYRCLE's tool.

Results:

A total of nine pre-clinical studies on animal models were included. Although the dose
and route of MSCs applied were quite heterogeneous, results showed that MSCs displayed protective
effects on intestinal inflammation, including mice general assessment, immunoregulation,
and intestinal barrier integrity. Meanwhile, studies showed positive effects on the composition of
gut flora with MSCs administration, which had been characterized by restoration of Firmicutes/
Bacteroides balance and reduction of Proteobacteria. The beneficial bacteria Akkermansia,
Bifidobacterium, and Lactobacillus were also distinctly enriched, and the pathogenic bacteria
Escherichia-Shigella was conversely decreased. The alpha and beta diversity were also regulated
to resemble those of healthy mice. Microbial metabolic functions, such as biosynthesis of secondary
bile acid and sphingolipid metabolism, and some biological behaviors related to cell regeneration
were also up-regulated, while cancer function and poorly characterized cellular function
were down-regulated.

Conclusion:

Current data support the remodeling effect on gut microbiota with MSC administration,
which provides a potential therapeutic mechanism for MSCs in the treatment of IBD. Additional
studies in humans and animal models are warranted to further confirm the role of gut microflora
in MSCs repairing IBD.
Characterization of the Prognosis and Tumor Microenvironment of Cellular
Senescence-related Genes through scRNA-seq and Bulk RNA-seq Analysis
in GC
Authors: Guo Guoxiang , Zhou Zhifeng , Chen Shuping , Cheng Jiaqing , Wang Yang , Lan Tianshu , Ye Yunbin
Published: October 2023

Background:

Cellular senescence (CS) is thought to be the primary cause of cancer
development and progression. This study aimed to investigate the prognostic role and molecular
subtypes of CS-associated genes in gastric cancer (GC).

Materials and Methods:

The CellAge database was utilized to acquire CS-related genes. Expression
data and clinical information of GC patients were obtained from The Cancer Genome
Atlas (TCGA) database. Patients were then grouped into distinct subtypes using the “Consesus-
ClusterPlus” R package based on CS-related genes. An in-depth analysis was conducted to assess
the gene expression, molecular function, prognosis, gene mutation, immune infiltration,
and drug resistance of each subtype. In addition, a CS-associated risk model was developed
based on Cox regression analysis. The nomogram, constructed on the basis of the risk score and
clinical factors, was formulated to improve the clinical application of GC patients. Finally, several
candidate drugs were screened based on the Cancer Therapeutics Response Portal (CTRP)
and PRISM Repurposing dataset.

Results:

According to the cluster result, patients were categorized into two molecular subtypes
(C1 and C2). The two subtypes revealed distinct expression levels, overall survival (OS) and
clinical presentations, mutation profiles, tumor microenvironment (TME), and drug resistance.
A risk model was developed by selecting eight genes from the differential expression genes
(DEGs) between two molecular subtypes. Patients with GC were categorized into two risk
groups, with the high-risk group exhibiting a poor prognosis, a higher TME level, and increased
expression of immune checkpoints. Function enrichment results suggested that genes were enriched
in DNA repaired pathway in the low-risk group. Moreover, the Tumor Immune Dysfunction
and Exclusion (TIDE) analysis indicated that immunotherapy is likely to be more beneficial
for patients in the low-risk group. Drug analysis results revealed that several drugs, including
ML210, ML162, dasatinib, idronoxil, and temsirolimus, may contribute to the treatment of GC
patients in the high-risk group. Moreover, the risk model genes presented a distinct expression
in single-cell levels in the GSE150290 dataset.

Conclusion:

The two molecular subtypes, with their own individual OS rate, expression patterns,
and immune infiltration, lay the foundation for further exploration into the GC molecular
mechanism. The eight gene signatures could effectively predict the GC prognosis and can serve
as reliable markers for GC patients.
MSSD: An Efficient Method for Constructing Accurate and Stable Phylogenetic Networks by Merging Subtrees of Equal Depth
Authors: Xing Jiajie , Song Xu , Yu Meiju , Wang Juan , Yu Jing
Published: October 2023

Background:

Systematic phylogenetic networks are essential for studying the evolutionary
relationships and diversity among species. These networks are particularly important for capturing
non-tree-like processes resulting from reticulate evolutionary events. However, existing methods
for constructing phylogenetic networks are influenced by the order of inputs. The different orders
can lead to inconsistent experimental results. Moreover, constructing a network for large datasets is
time-consuming and the network often does not include all of the input tree nodes.

Aims:

This paper
aims to propose a novel method, called as MSSD, which can construct a phylogenetic network from
gene trees by Merging Subtrees with the Same Depth in a bottom-up way.

Methods:

The MSSD first decomposes trees into subtrees based on depth. Then it merges subtrees
with the same depth from 0 to the maximum depth. For all subtrees of one depth, it inserts each subtree
into the current networks by means of identical subtrees.

Results:

We test the MSSD on the simulated data and real data. The experimental results show that
the networks constructed by the MSSD can represent all input trees and the MSSD is more stable
than other methods. The MSSD can construct networks faster and the constructed networks have
more similar information with the input trees than other methods.

Conclusion:

MSSD is a powerful tool for studying the evolutionary relationships among species in
biologyand is free available at https://github.com/xingjiajie2023/MSSD.
Stem Cell Therapy for the Management of Type 1 Diabetes: Advances and
Perspectives
Authors: Goyal Priyanshi , Malviya Rishabha
Published: October 2023

Due to insulin resistance and excessive blood sugar levels, type 1 diabetes mellitus (T1DM) is characterized by pancreatic cell loss. This condition affects young people at a higher rate than any other chronic autoimmune disease. Regardless of the method, exogenous insulin cannot substitute for insulin produced by a healthy pancreas. An emerging area of medicine is pancreatic and islet transplantation for type 1 diabetics to restore normal blood sugar regulation. However, there are still obstacles standing in the way of the widespread use of these therapies, including very low availability of pancreatic and islets supplied from human organ donors, chal-lenging transplantation conditions, high expenses, and a lack of easily accessible methods. Ef-forts to improve Type 1 Diabetes treatment have been conducted in response to the disease's increasing prevalence. Type 1 diabetes may one day be treated with stem cell treatment. Stem cell therapy has proven to be an effective treatment for type 1 diabetes. Recent progress in stem cell-based diabetes treatment is summarised, and the authors show how to isolate insulin-pro-ducing cells (IPCs) from a variety of progenitor cells.
Review of Research on Dynamic Characteristics of Rolling Bearing Cages
Authors: Pan Chengyi , Li Shuhao , Zhang Jingren
Published: October 2023

Background:

Rolling bearings are beingwidely used in various applications because of
their unique functions, but at the same time, bearing failures are becoming more and more prominent.
Among them, the bearing failure caused by cage failure also accounted for 25% of the total
proportion. With the progress of intelligent manufacturing and "Industry 4.0", the operating environment
of rolling bearings is becoming increasingly complex and variable, and higher demands
are made on the dynamic characteristics of cages. In this regard, the research on the nonlinear dynamics
of the cell under different influencing factors can help to explain better the mechanism of
dynamic, unstable motion of the cage under various influencing factors and solve the bearing life
and reliability problems caused by uneven rolling bearing cage from the perspective of design and
experimental research.

Objective:

By summarizing the influencing factors of cage dynamics characteristics, the design of
new structures, test methods, and testing devices of dynamics attributes in recent years, some valuable
conclusions were obtained, and the future development direction of rolling bearing cage dynamics
characteristics was proposed to provide a reference for researchers in related fields.

Method:

This paper reviews the patents and documents related to the dynamic characteristics of
rolling bearing cages, as well as analyzes the different influencing factors on the operational stability
of the bearings, and introduces the improved design of cage structures, as well as the test
methods and testing devices for the dynamic characteristics of cages.

Results:

Through the analysis of relevant patents and papers on rolling bearing cage dynamics,
the development status and problems of rolling bearing cage dynamics were discussed, future research
on rolling bearing cage dynamics was prospected, and design ideas and research directions
were proposed.

Conclusion:

Through the discussion of the factors influencing the cage dynamics, the optimization
of the rolling bearing cage structure design, and the study of test methods and testing devices,
it was found that the research direction of the rolling bearing cage dynamics needs to be further
expanded so that a better research method and testing devices could be researched, and a new
structure with more stable operation and higher cage life and reliability could be designed.
Plicatin C: A New Cinnamate Derivative from Mangrove-derived Fungus
Aspergillus terreus DM62
Authors: Tian Danmei , Chen Mei , Ding Wenjuan , Li Jia , Wu Shi , Hong Kui , Tang Jinshan
Published: October 2023

Background:

Marine fungi have been proven to be a new arsenal for the discovery of
valuable secondary metabolites.

Method::

Fungus strain Aspergillus terreus DM62 was initially fermentated using solid corn medium
and PDA liquid medium. Subsequently, extensive chromatographic methods were applied to isolate
the fermentation cultures of DM62, and the chemical structures of isolate compounds were elucidated
by pectroscopic analyses and optical rotations comparison. Additionally, α-glucosidase and ATPcitrate
lyase (ACL) inhibitory activities of isolate compounds were assessed to investigate their hypoglycemic
and lipid-lowering activities.

Result::

A new cinnamate derivative, plicati n C (1), together with 18 known compounds, were isolated
from the solid and liquid state fermentations of A. terreus DM62. Activity evaluation showed that compounds
3, 6, and 8-10 exhibited stronger α-glucosidase inhibitory activities than acarbose at 400 μM,
and butenolide 3, with an IC50 value of 21.5 μM, was discovered with significant ACL inhibitory
activity for the first time.

Conclusion::

This study not only discovered a new cinnamate derivative but also found butenolides
with potent ACL inhibitory activity, which is favorable to clarify their pharmacological mechanism
in the treatment of metabolic disease.
NiO@PANI based Nanocomposites as an Advanced Functional Material:
Experimental and Computational Approach
Authors: Kumar Harish , Luthra Manisha
Published: October 2023

Background::

Individually, metal nanoparticles (NPs) and conducting polymers show
unique properties due to small size, large surface area, and high order of conductivity. But their
combination may result in a synergistic effect in properties.

Methods::

The NiO NPs and conducting polymer Polyaniline were prepared by modified Sol-gel
and chemical oxidative methods, respectively. Powder XRD, FTIR, TEM, and UV-visible methods
were used for the structural evaluation. The computational (DFT) study was performed to
support experimental results. The NiO/Polyaniline (PANI) nanocomposites (NCs) were explored
as corrosion inhibitors, electrical conductors, and photocatalytic agents.

Results::

The NiO/Polyaniline NCs showed 91.52% corrosion inhibition efficiency at 1000 ppm
concentration. The photocatalytic activity was investigated against methylene blue dye under ultraviolet
light. The NiO/Polyaniline NCs decompose 90% of organic dye. The NCs exhibit good
conducting, corrosion inhibition, and photocatalytic activity.

Conclusion::

The metal oxide (NiO NPs) and PANI-based NCs can be used as corrosion inhibitors,
conducting material, and for the degradation of organic compounds (dyes) in impure water.
6 ŞUBAT KAHRAMANMARAŞ DEPREMLERİNDE ÇOCUKLARIN YAŞADIKLARI VE EBEVEYNLERİNDE TANIK OLDUĞU DUYGU DURUMLARI
Authors: Darga Hatice
Published: October 2023

Bu araştırma 6 Şubat’ta Pazarcık ve Elbistan depremlerine maruz kalan çocukların ve ebeveynlerin yaşadıkları durumlar ile çocukların ebeveynlerinde tanık oldukları duygu durumlarını belirlemeyi amaçlamıştır. Nitel araştırma yöntemi ve fenomenolojik desende yürütülen çalışmanın verileri, açık uçlu ve yarı yapılandırılmış sorular ile yüz yüze görüşme yoluyla toplanmıştır. Veriler içerik analizi ile çözümlenmiş, tema, kategori ve kodlar oluşturulmuştur. Çalışma grubu deprem bölgesinden gelip, Bucak Devlet öğrenci yurdunda barınan, 14 ebeveyn ve toplam 29 çocuktan oluşmaktadır. Görüşmeler ebeveynler ile gerçekleştirilmiştir. Sonuçlara göre, ebeveyn ve çocuklar sarsıntılar sırasında ve sonrasında travmatik deneyimler yaşamıştır. Sarsıntılar sırasında ve sonrasında yıkıntılar ve insanların kaotik hallerini görmüşlerdir. Ayrıca ebeveynlerinin paniklemek, ağlamak, çığlık atmak, korkmak, donakalmak gibi duygu durumlarına tanık olmuş ve benzer tepkiler vermiştir. Ebeveynlerin izlediği deprem bölgesi haberleri ve görüntülerini çocuklar da görmüş, deprem ile ilgili tüm konuşmalarına tanık olmuşlardır. Çocuklarda görülen duygu ve davranış değişikliklerinden bazıları, deprem korkusu, ölüm korkusu, evine dönmek istememek, uyuyamamak, öfke patlamaları, tahammülsüzlük depremi sorgulamak, anneden ayrılmamaktır.
Modelo de probabilidad de ocurrencia del caracol gigante africano (Achatina fulica) para Boyacá, Colombia
Authors: Sánchez Rojas Edwin Fernando , Gómez Cedeño Maijdinayiver Mairán , Cárdenas Cárdenas María Alejandra , Gil Padilla Luz Nidia
Published: October 2023

La capacidad invasora y la historia natural de Achatina fulica (Linnaeus, 1758) posiciona esta especie como una de las 100 especies invasoras más peligrosas a nivel mundial.  Su estudio ha trascendido los límites de la investigación biológica para complementarse con análisis de predicción de los comportamientos ecológicos y la influencia de los factores sociales y económicos. El objetivo de la investigacion fue generar un modelo de probabilidad de ocurrencia para el caracol gigante africano, a escala espacial y temporal. Se recopilaron registros de presencia de la especie mediante información secundaria para el departamento de Boyacá; la información bioclimática se obtuvo a partir de la plataforma Worldclim, los indicadores sociales y económicos de cada localidad se extrajeron de la base de datos Terridata-dnp. La información se analizó por medio de software estadístico R Studio, mediante los paquetes ENMTML y ISLR.  Para el modelamiento se utilizó el algoritmo de máxima entropía (Maxent); la validación del modelo se realizó con las métricas AUC, TSS, Kappa, Sorensen y Jaccard. Las variables bioclimáticas que más influyeron en el modelo de probabilidad de ocurrencia fueron temperatura, precipitación y humedad; así mismo, se determinó que las variables cobertura de acueducto y área deforestada están relacionadas estadísticamente en los municipios en donde se ha reportado la especie invasora en el departamento. En las condiciones actuales el caracol gigante africano, podría establecerse en aproximadamente 11.209,74 km; es decir, en el 47,54% del territorio boyacense; bajo las condiciones socioeconómicas de la predicción futura, en el escenario ssp1 126 la especie podría ampliar su presencia hasta el 63.25% y en el escenario ssp4 585 al 50,42%, siendo este último el más caótico se encontró que la ocupación puede ser menor al primer escenario, pero la probabilidad de ocurrencia es más alta.
Acceptance of the Apple Watch Series 6 for Telemonitoring of Older Adults With Chronic Obstructive Pulmonary Disease: Qualitative Descriptive Study Part 1
Authors: Arnaert Antonia , Sumbly Pia , da Costa Daniel , Liu Yuxin , Debe Zoumanan , Charbonneau Sylvain
Published: October 2023

Background

The Apple Watch is not a medical device per se; it is a smart wearable device that is increasingly being used for health monitoring. Evidence exists that the Apple Watch Series 6 can reliably measure blood oxygen saturation (SpO2) in patients with chronic obstructive pulmonary disease under controlled circumstances.

Objective

This study aimed to better understand older adults’ acceptance of the Watch as a part of telemonitoring, even with these advancements.

Methods

This study conducted content analysis on data collected from 10 older adults with chronic obstructive pulmonary disease who consented to wear the Watch.

Results

Using the Extended Unified Theory of Acceptance and Use of Technology model, results showed that participants experienced potential health benefits; however, the inability of the Watch to reliably measure SpO2 when in respiratory distress was concerning. Participants’ level of tech savviness varied, which caused some fear and frustration at the start, yet all felt supported by family and would have explored more features if they owned the Watch. All agreed that the Watch is mainly a medical tool and not a gadget.

Conclusions

To conclude, although the Watch may enhance their physical health and well-being, results indicated that participants are more likely to accept the Watch if it ultimately proves to be useful when experiencing respiratory distress.
Supporting Pain Self-Management in Patients With Cancer: App Development Based on a Theoretical and Evidence-Driven Approach
Authors: Abahussin Asma A , West Robert M , Wong David C , Ziegler Lucy E , Allsop Matthew J
Published: October 2023

Background

To inform the development of an intervention, it is essential to have a well-developed theoretical understanding of how an intervention causes change, as stated in the UK Medical Research Council guidelines for developing complex interventions. Theoretical foundations are often ignored in the development of mobile health apps intended to support pain self-management for patients with cancer.

Objective

This study aims to systematically set a theory- and evidence-driven design for a pain self-management app and specify the app’s active features.

Methods

The Behavior Change Wheel (BCW) framework, a step-by-step theoretical approach to the development of interventions, was adopted to achieve the aim of this study. This started by understanding and identifying sources of behavior that could be targeted to support better pain management. Ultimately, the application of the BCW framework guided the identification of the active contents of the app, which were characterized using the Behavior Change Technique Taxonomy version 1.

Results

The theoretical analysis revealed that patients may have deficits in their capability, opportunity, and motivation that prevent them from performing pain self-management. The app needs to use education, persuasion, training, and enablement intervention functions because, based on the analysis, they were found the most likely to address the specified factors. Eighteen behavior change techniques were selected to describe precisely how the intervention functions can be presented to induce the desired change regarding the intervention context. In other words, they were selected to form the active contents of the app, potentially reducing barriers and serving to support patients in the self-management of pain while using the app.

Conclusions

This study fully reports the design and development of a pain self-management app underpinned by theory and evidence and intended for patients with cancer. It provides a model example of the BCW framework application for health app development. The work presented in this study is the first systematic theory- and evidence-driven design for a pain app for patients with cancer. This systematic approach can support clarity in evaluating the intervention’s underlying mechanisms and support future replication.
Safety evaluation of empagliflozin for patients with type 2 diabetes and chronic kidney disease
Authors: Tuttle Katherine
Published: October 2023

Dr Tuttle presents a recent evaluation of the safety of empagliflozin in in patients with both type 2 diabetes and chronic kidney disease.
El Actual Proceso Legislativo de Reforma Constitucional en México
Authors: Valderrama Tarango Julio César
Published: October 2023

En este estudio se abordará el proceso actual de reforma constitucional para conocer cómo se estructura positivamente en la Constitución un poder revisor en el artículo 135, así mismo se muestra la supletoriedad de los artículos 71 y 72 como guías en el acuerdo de reforma o modificación a la Carta Magna
El Poder Ejecutivo y la Planeación Económica del Estado Mexicano
Authors: Gómez Díaz Dulce Angelina
Published: October 2023

El propósito de este artículo es conocer mediante el análisis de la relación e incidencia que tiene el Poder Ejecutivo en la planeación económica del Estado mexicano, una del as funciones más importantes que la Constitución Política de los Estados Unidos Mexicanos le asigna al Estado que es el desarrollo nacional.
A Predictive Model Using Deep Learning Neural Network for Efficient Intrusion Detection
Authors: Priyavengatesh A.
Published: October 2023

Abstract: Network intrusion detection system helps to detect exploitations and mitigate damages. A network intrusion detection system detects the network traffic that deviates from the normal behavioral pattern. Developing an efficient intrusion detection system has many challenges and the patterns associated with one type of intrusion differ from other intrusions. In such situations, understanding different patterns and differentiating intrusions becomes essential to detect anomalies and attacks in the network. Deep learning models offer more power and intelligence to the detection system and extend the ability to differentiate & understand the network feature characteristics, also machine learning models with feature selection showed high performance in intrusion detections. This paper evaluates the proposed deep learning neural network model and machine learning models using feature selection for efficient intrusion detection using real world dataset.
Artificial Intelligence
Authors: Kaur Ms. Parminder
Published: October 2023

Abstract: A multidisciplinary discipline called artificial intelligence (A.I.) aims to automate jobs that currently need human intelligence. Artificial intelligence (AI), while not being well known, is a technology that is revolutionising all facets of existence. In order to rethink how we mix data, analyse it, and make decisions, this article attempts to inform laypeople about AI and urge them to use it as a tool in various fields. In this post, we briefly discussed artificial intelligence (AI), its principles, and potential applications.
Opportunities and Challenges with Cloud Computing
Authors: Kaur Ms. Ranvir , Kaur Ms. Harmandeep
Published: October 2023

Abstract: Pall computing is a model for furnishing computing service similar as storehouse, waiters, services and operations, without physically acquiring them via the internet. Access to similar service could be free or pay as per use. So that the associations doesn't have to spent time and cost in managing them numerous business institutions are moving towards the pall calculating due to the effectiveness of services and pay- per- use pattern. This pay- per- use pattern grounded on the coffers consumption processing power, deals carried out, bandwidth consumed, data transferred, or storehouse space enthralled etc. In pall calculating the customer data is maintained in the data center of a pall provider like Tata, Netmagic, Google, Amazon and Microsoft etc. Since the data is stored on Internet pall the stoner will have limited or no control over the data, which may lead to colorful security issues. Since the data guardianship is at a data center which could lead to pitfalls similar as data leakage, insecure interface, sharing of coffers, data vacuity and inside attacks etc. There are colorful challenges for espousing pall calculating similar as well managed service position agreement( SLA), Confidentiality, Integrity and Vacuity( CIA). This exploration paper outlines pall computing assiduity models and issues associated with it. This exploration paper assay the challenges which are present in pall computing and stylish practices by service providers.
TAYO Cards in Understanding Numbers 1-10 for Early Childhood, Improve?
Authors: Abus Odilia , Usmiyatun
Published: October 2023

Judul penelitian ini adalah untuk meningkatkan kemampuan memahami konsep bilangan pada anak usia 4-5 tahun melalui media kartu bilangan di PAUD Anak Ceria Jawang Golokantar Manggarai Timur tahun ajaran 2022/2023. Rumusan masalah penelitian adalah: Bagaimanakah upaya untuk meningkatkan kemampuan memahami konsep bilangan pada anak usia 4-5 tahun melalui media kartu bilangan di PAUD Ceria Anak Jawang Golokantar tahun pelajaran 2022/2023? Tujuannya untuk mengetahui bagaimana cara meningkatkan kemampuan memahami konsep bilangan pada anak usia 4-5 tahun melalui media kartu bilangan di PAUD Ceria Anak Jawang Golokantar. Penelitian ini merupakan Penelitian Tindakan Kelas yang dilakukan dengan 15 siswa Kelompok A PAUD Ceria Anak sebagai subjek penelitian. Penelitian ini dilakukan dalam dua siklus. Tahapan dalam setiap siklus terdiri dari perencanaan, pelaksanaan, observasi, dan refleksi. Hasil penelitian menunjukkan bahwa penggunaan media kartu bilangan dapat meningkatkan kemampuan memahami konsep bilangan pada anak usia 4-5 tahun di PAUD Ceria Jawang Desa Golokantar Kecamatan Borong Kabupaten Manggarai Timur. Peningkatan ini terlihat dari peningkatan persentase pelaksanaan tindakan pada siklus I dan II. Pelaksanaan tindakan pada siklus I dengan persentase ketuntasan 60%, kemudian peningkatan persentase yang signifikan ditunjukkan pada pelaksanaan siklus II menjadi 93,33%. Peningkatan ini terlihat dari peningkatan persentase pelaksanaan tindakan pada siklus I dan II. Pelaksanaan tindakan pada siklus I dengan persentase ketuntasan 60%, kemudian peningkatan persentase yang signifikan ditunjukkan pada pelaksanaan siklus II menjadi 93,33%. Peningkatan ini terlihat dari peningkatan persentase pelaksanaan tindakan pada siklus I dan siklus II. Pelaksanaan tindakan pada siklus I dengan persentase ketuntasan 60%, kemudian peningkatan persentase yang signifikan ditunjukkan pada pelaksanaan siklus II menjadi 93,33%
Comparison of Anthropometric Characteristics and Biomotor Ability Variables of Athletes in Different Combat Sports
Authors: SATILMIŞ Nuray , SÖYLER Mehmet , KILINÇARSLAN Gökmen
Published: October 2023

This study aims to compare the anthropometric characteristics and the biomotor ability variables of the athletes in boxing, taekwondo, and wrestling and examine the relationships of the research variables in terms of branches. A total of 83 voluntary male athletes who took part in the national teams participated in the research in the branches of boxing (n=28), wrestling (n=33) and taekwondo (n=22). The mean age of the participants was 20.4, and the mean weight and height were 75,5 and 174,9. The mean BMI of the participants was 24,5. Indirect VO2max values of the athletes were obtained based on their height, weight, BMI, grip strength, squat jump (SJ) and countermovement jump (CMJ), anaerobic strength obtained from a vertical jump, standing long jump, 30 meters speed test and 20 meters shuttle running test. There was no significant difference between the groups regarding grip strength, anaerobic power and VO2max abilities. When the groups were compared regarding sprint values, there were significant differences between the athletes in the taekwondo and wrestling branches (p
Effect of disease acceptance in geriatric individuals on life satisfaction
Authors: DÜZGÜN Gönül , POLAT Gökşen , GÜL Selden , ÜNSAL AVDAL Elif
Published: October 2023

Introduction: Elderly must maintain regular care and complex treatment of several chronic diseases that develop with age or that pre-exist. Having a chronic disease entail both a feeling of loss and the need to keep the disease and one’s life under control. It is important for these individuals to accept their illness while maintaining treatment and care. Life satisfaction, on the other hand, is the result of comparing what a person has with his or her expectations. This analytical cross-sectional study was conducted to examine the effect of disease acceptance on the life satisfaction of geriatric individuals. Methods: The research type is analytical cross-sectional study. The research was conducted between February 1-July 31, 2019 in a hospital in Izmir, in Türkiye. A total of 140 individuals over the age of 65 were included. A sociodemographic questionnaire, the Disease Acceptance Scale, and the Life Satisfaction Scale were used as data collection tools. Results: The mean disease acceptance score of the elderly individuals was 25.95 ± 5.25, and the life satisfaction score was 20.39 ± 5.94. Cardiology, endocrinology, dermatology, and gastroenterology patients evaluated their health as good, while individuals with respiratory system diseases evaluated their health as bad. A significant relationship was also found between marital status, disease type, health assessment status, and life satisfaction. While the life satisfaction of married individuals was borderline significant, it was determined that the life satisfaction of individuals with respiratory problems and poor health status was low. When the scores of the two scales were compared, a moderate positive correlation was found. Conclusion: There is a strong correlation between the acceptance of illness and life satisfaction of elderly individuals. When older individuals accept their illness, their life satisfaction also increases. When older individuals accept their illness, their life satisfaction also increases. Socioeconomic status of elderly individuals and having more than one disease play an active role in accepting the disease and life satisfaction. The importance of accepting the disease should be considered in order to increase life satisfaction. Keywords: Aging, elderly, satisfaction
Family physicians' opinions on examination fear and telemedicine during the pandemic
Authors: GELMEZ TAŞ Beray , ZEREN OZTURK Güzin , ÖZMEN SEVER Seda , AKSU Saliha Büşra
Published: October 2023

Introduction: During Covid-19 pandemic, many hospitals closed their outpatient clinics because of the high number of inpatients and individuals turned to their family physicians for medical care. In this study, we aimed to evaluate the opinions of family physicians regarding examination phobia and telemedicine video examinations during the pandemic.
Methods: This was a single-centered, cross-sectional study. The participating physicians completed a questionnaire with 28 questions including their sociodemographic data, whether they performed examination during the pandemic, telemedicine knowledge and opinions on telemedicine. Statistical analysis was conducted using SPSS 20 software package and statistical significance was set at p<0.05.
Results: 364 family physicians participated in our study and 163 of them (44.8%) reported hesitation while examining patients, with the majority (53.8%; n=196) expressing anxiety about oropharyngeal examinations. 211 of them (58%) reported having knowledge of telemedicine. The majority of family physicians thought that follow-ups and prescriptions for chronic diseases, repeat prescriptions, and post-treatment control examinations could be performed online whereas pregnant, postpartum, infant, and child follow-ups could not. While 40% (n=146) didn’t want to provide services via video/telephone examination, 32.7% (n=119) wanted to and 27.2% (n=99) undecided. 86.8% (n=316) of them believed that telemedicine video/telephone examination could result in legal problems. Participants estimated that less than 25% of their daily patients were suitable for telemedicine, and that less than 25% had access to the necessary technology. However, 55.8% (n=203) of family physicians believed that patients would be interested in telemedicine, and 59.6% (n=216) thought that providing such services would increase their workload. Being undecided about providing services through telemedicine was more common among women (p=0.029), while unwillingness to provide online services increased with age and years of occupation (p=0.024, p=0.004, respectively).
Conclusion: Telemedicine, which has come to the forefront with the development of technology today, was seen as an opportunity to reduce contact with patients during the pandemic. However, our study found that family physicians believed that telemedicine services would increase their workload and that a large portion of society was not ready for this system.
Keywords: Telemedicine, telehealth, covid 19, family physician.
Identifying types of behavior of food SMEs towards food waste management
Authors: Nurisusilawati Isnaini , Qista Karima Halim
Published: October 2023

Food waste is a significant sustainable challenge in Indonesia, particularly in commercial centers like Banyumas, it ranks as the second largest source of food waste. Despite the availability of information on food waste management, a substantial amount of food waste continues to be generated by food Small and Medium-sized Enterprises (SMEs). This research aims to categorize food SMEs in Banyumas based their food waste management behavior. The Extended Norm Activation Model framework was employed to assess the behavior of food SMEs in managing food waste. A questionnaire survey was conducted on 115 food SMEs in Banyumas, leading to the formation of two clusters through K-Means clustering: unmanageable and manageable. The unmanageable cluster exhibited the lowest levels of knowledge, awareness, and intention regarding food waste management and still requires substantial improvement in managing food waste. In contrast, the manageable cluster comprises food SMEs that have successfully implemented food waste management practices. These businesses demonstrate a heightened awareness of the food waste issue, take individual responsibility for addressing it, actively work to reduce waste. The finding of this research can serve as a basis fpr developing tailored mitigation strategies based on the behavior of SMEs in each cluster.
Coverage and Influencing factors of Influenza Vaccination among the elderly in Minhang District, Shanghai
Authors: Zhang Xiaohua , Jie Zhijun , Zhang Liping , Hu Xiaoying , Zhang Yanan , Ling Ping , Lu Jia , Feng Jingjing , Shi Tianyun , Ren Xiaoting
Published: October 2023

Objectives: To describe the influenza vaccination coverage and identify
its influencing factors, and understand the reasons for not receiving
influenza vaccination among the elderly in Minhang District, Shanghai.
Methods: The influenza vaccination coverage among the elderly in Minhang
District of Shanghai was described by collating the data of influenza
vaccination from August 1, 2014 to July 31, 2019 for elderly people aged
≥60 years provided by Minhang District Center for Disease Control and
Prevention (CDC).And a telephone survey was conducted among vaccinated
and unvaccinated older adults during the 2018-2019 influenza season
using a self-designed questionnaire in August-December 2020. Results:
Influenza vaccination coverage rate among the elderly was 0.68%,
0.62%, 0.67%, 0.92% and 1.36% in the influenza season from 2014/2015
to 2018/2019 respectively. Higher influenza vaccination was associated
with females (odds ratio (OR):1.937), independent living (OR:8.700),
self-perceived poor health status (OR:4.445), having recommendations
from physicians (OR:5.052) or family members (OR:3.449), former smokers
(OR:4.509), past pneumococcal vaccination (OR:52.172) and past influenza
infection (OR:15.184). In addition, the elderly with chronic bronchitis
(OR:1.808), COPD (OR:3.161), bronchiectasis (OR:5.146) and diabetes
mellitus (OR:2.030) were positively associated with vaccination. The
main reason for not receiving influenza vaccination were believing they
were healthy and did not need to get vaccinated (40.0%). Conclusions:
The influenza vaccination coverage rate was relatively low among the
elderly in Minhang District, Shanghai. The awareness and willing about
vaccinations in elderly people should be increased.
Weighted Hermite-Hadamard-type inequalities for generalizations of Steffensen’s inequality via the extension of Mongomery identity
Authors: Pecaric Josip , Perusic-Pribanic Anamarija , Smoljak-Kalamir Ksenija
Published: October 2023

In this paper, we obtain some new weighted Hermite-Hadamard-type inequalities which involve generalizations of Steffensen?s inequality obtained by using the extension of Montgomery identity via Taylor?s formula. Further, we show that by using the extension of Montgomery identity via Fink?s identity we can obtain some other weighted Hermite-Hadamard-type inequalities.
Análisis de la producción y exportación de amaranto para determinar su gestión logística a la unión europea
Authors:   Instituto Superior Tecnológico Vicente Rocafuerte, Suarez Mora Olga María , Silva Pérez Evelyn Johana
Published: October 2023

La globalización en la actualidad, está obligando a los países a volverse más competitivos y, por lo tanto, también más productivos. Ecuador no puede ser la excepción. Durante años, los estudios para exportaciones del país se han fundamentado únicamente en los productos tradicionales de exportación, tales como cacao, banano y petróleo, los cuales han saturado la demanda y tienen una fuerte oferta, por lo que se hace más competitivo el mercado. Con estos informes, se puede observar otros productos no tradicionales que tienen alta demanda en el mercado internacional, pero su producción y comercialización no están lo suficientemente desarrolladas para poder cumplir con dicha demanda. Es este el caso del Amaranto, producto que, aunque no se encuentra como los principales de exportación, se estima que en el futuro sea uno de los más importantes productos demandados a nivel mundial, sobre todo en países como Estados Unidos y la Unión Europea, debido a las importantes propiedades recientemente redescubiertas de este pseudocereal. Por este motivo se desarrollará un análisis de la producción y exportación de la planta de Amaranto, ya se debe impulsar la agricultura y usar estos medios en pro de la economía; en tanto más y mejores productos se pueda ofertar al mercado se conseguirá la Balanza Comercial positiva; además de las divisas que Ecuador recibiría, con el crecimiento de la exportación del Amaranto al mercado europeo, específicamente en la plaza europea