bluuebunny/crossref_metadata_2025 huggingface dataset:
TAX AMNESTY IN UKRAINE: FEATURES AND RESULTS
Authors:   Research Institute of Financial Policy of the State Tax University, Fradynskyi Oleksandr
Published: September 2023

The article is devoted to the study of the peculiarities of tax amnesty in Ukraine. In the course of the research, it was found that tax amnesty is not only a need for the socio-economic life of society, but also the implementation of the pre-election program of the current government. It is emphasized that this is the first comprehensive attempt to implement tax amnesty in practice as a tool of financial and tax regulation of the economy. The classification of amnesties in economic activity (tax amnesty, capital amnesty, economic amnesty) was carried out and it was concluded that the Ukrainian version of the amnesty belongs to economic amnesties. The experience of the most successful foreign countries in this field (Indonesia, Argentina, the Republic of Kazakhstan, Italy) was studied. It has been established that world practice proves that the economic benefit of the state during the amnesty can be realized in 3 main ways: depositing legalized funds by declarants in interest-free deposits in state banks for a specified period of time; payment of a one-time tax, which is either equal to the basic rate of income tax, or, as is very often the case in practice, much lower (by 2–3 times) than the basic level; the purchase of government debt securities (usually bonds) with a long period of rotation on the conditions of the absence of fines or the payment of a fixed tax at a small rate. The fiscal, regulatory, investment and social functions of the tax amnesty are characterized and the characteristic features of its implementation in Ukraine are summarized. The opinion was expressed that, despite possible positive benefits in the course of the tax amnesty, it contradicts certain provisions of the Constitution of Ukraine and the principles of taxation, which are reflected in the Tax Code, and may lead to negative expectations among domestic businesses. It was found that according to the results of the tax amnesty, it cannot be considered successful, taking into account the financial expectations that were at the beginning of its implementation and the actual results achieved. this is a long-overdue objective process that requires its implementation in Ukraine. It was concluded that, despite the urgent need to hold a tax amnesty in Ukraine, the failure was due to the incorrectly chosen time of its holding, which fell on the period of the active phase of Russian aggression; lack of significant changes in the current fiscal legislation, trust in the domestic judicial system, effective fight against corruption; conducting active public outreach work among society.
EVALUATION OF ECONOMIC DEVELOPMENT AND INVESTMENT IN CHINA
Authors:   Sumy National Agrarian University, Sokhan Inna , Zhuoran Li ,   Sumy National Agrarian University
Published: September 2023

With the globalization of economy, China is playing an increasingly important role in the world economy. As a part of China's economy, the development of agricultural economy has influenced the development of China's economy. At present, China's economic growth rate has decreased slightly due to the impact of the epidemic. China's economic development has kept in touch with the world economy. This article evaluates the current state of economic development and investment in China under the influence of globalization process and external economic processes. It also examines in detail the theoretical foundations and practical application of agricultural investment management, with the aim of providing useful recommendations and reference materials for decision-makers in the agricultural sector by defining basic concepts, analyzing the foundations of theory and research methods.
ELECTRIC TRANSPORT AS A COMPONENT OF A LOW-CARBON ECONOMY
Authors:   Odesa National Economic University, Razinkin Nikita
Published: September 2023

The issue of modern and environmentally friendly electric transport has gained significant attention in recent years, and its impact on the low-carbon economy cannot be overstated. Ukraine is no exception, as the need to reduce carbon emissions becomes more pressing. Despite this, the development of a low-carbon economy has not been a priority in Ukraine, and the implementation of an electric transport ecosystem could provide an opportunity to shift towards a more sustainable future. The development of an electric transport ecosystem in Ukraine requires a multifaceted approach, which involves the creation of charging infrastructure, the production of electric vehicles, attracting foreign electric car manufacturers, and ensuring the availability of electric vehicles for the population. Additionally, education and public awareness campaigns should be implemented to inform the public about the benefits of this area and to encourage the adoption of electric vehicles. One of the key challenges in the implementation of an electric transport ecosystem in Ukraine is the lack of charging infrastructure. However, there have been some initiatives in this area, such as the installation of charging stations in major cities and the introduction of incentives for the development of charging infrastructure. Another challenge is the lack of local production of electric vehicles. While there are some companies that produce electric vehicles in Ukraine, they are not widely available or well-known. Attracting foreign electric car manufacturers could help address this issue and provide a wider variety of electric vehicles for the population. If the project to create an electric transport ecosystem in Ukraine is successfully implemented, it could lead to numerous benefits, including an improvement in the environment, a reduction in the use of petroleum products, and a reduction in carbon dioxide emissions. This would not only benefit the environment but also provide economic benefits by creating jobs in the production and maintenance of electric vehicles and charging infrastructure. In summary, the development of a low-carbon economy in Ukraine is an important issue that requires immediate attention. The creation of an electric transport ecosystem can provide Ukraine with an opportunity to solve this problem.
BENCHMARKING OF COMPETITIVENESS ON THE EXAMPLE OF A NON-GOVERNMENTAL ORGANIZATION “SCHOOL OF BUSINESS AND MANAGEMENT”
Authors:   Vasyl Stefanyk Precarpathian National University, Boryshkevych Iryna , Yakubiv Valentyna ,   Vasyl Stefanyk Precarpathian National University
Published: September 2023

Benchmarking is a comparative analysis of the organization with the best direct and indirect competitors, as well as imitating their experience. It makes it possible to establish the key parameters of the organization’s activity, which should be worked on in order to achieve stable competitiveness. The purpose and main content of benchmarking is to identify the differences between the organization under study and the reference organization, as well as to establish the reasons for such differences and find ways to overcome them. Benchmarking objects include not only organizations in general, but also processes, technologies, methods, indicators of financial and economic activity, quality parameters, a motivation mechanism, development strategy formation, etc. The essence of benchmarking is to identify internal opportunities for improvement. By studying high-performing organizations, analyzing what makes that performance possible, and then comparing those processes to how your own organization works, you can make changes that lead to significant improvements. The article examines the essence of the concept of “benchmarking” in the works of domestic and foreign scientists, and offers its own interpretation. Types of benchmarking are grouped and characterized: performance benchmarking, process benchmarking, strategic benchmarking, internal benchmarking, competitive benchmarking, functional benchmarking, financial benchmarking, general benchmarking, and product benchmarking. The benchmarking implementation technology is considered through five successive stages: planning, data collection, analysis, implementation, control and evaluation. Benchmarking of competitiveness was carried out on the example of the non-governmental organization “School of Business and Management” in the part of the official website. The official websites of the business school of the Ukrainian Catholic University (LvBS) and one of the best European business schools – London Business School – were used for the analysis. In general, the use of benchmarking allows you to eliminate the weaknesses of the organization and realize existing opportunities to increase competitive advantages in the market.
THE ROLE OF DEVELOPMENT COMPANIES IN THE REAL ESTATE MARKET OF UKRAINE
Authors:   Classical Private University, Galtsova Olga , Seleznova Olena ,   Classical Private University, Melnyk Nadiia ,   Vasyl Stefanyk Precarpathian National University
Published: September 2023

The article studies the place and role of development companies in the domestic real estate market, in particular, identifies the main functions of development companies and peculiarities of organization of production activities of this participant in the real estate market. Despite the relatively recent emergence of such a new participant in the real estate market, many more problematic issues remain unresolved today related to the organization of development activities in the domestic real estate market, the definition of mechanisms for financial support for the implementation of development projects, and the creation of a regulatory framework for regulating development activities. It is worth paying attention to the comparative characteristics of development activities in Ukraine and abroad in order to identify the main problems of the development of professional development in Ukraine, as well as to conduct a thorough analysis of the factors that negatively affect the activities of development companies in the Ukrainian real estate market, in particular, it concerns the minimization of investment risks of development companies. Given the trend of increasing the number of development firms in the real estate market of Ukraine, the classification of types of developers is generalized and the characteristic features of their activities are determined. Developers as integral participants of the modern real estate market in Ukraine can perform a wide range of functional duties and act as an investor, organizer of a construction or investment project or an intermediary, while actively interacting with other participants in the microenvironment. The current state and prospects of development activity in the real estate market and further development of the real estate market of Ukraine are analyzed. Of course, the real estate market, like other industries in Ukraine, has undergone a significant reduction due to the rapid decline in demand, due to the beginning of a full-scale military invasion and the difficult economic situation in Ukraine. In general, today there is a positive trend in the real estate market, the previously launched construction and investment projects are gradually ending, which necessitates a quick response to all changes in the current real estate market and requires coordination of organizational, legal and information support for the activities of development companies in the real estate market of Ukraine.
New technologies in supporting ESG criteria and the implementation in the new normal: Mapping the field and proving future research paths
Authors: Secinaro Silvana , Calandra Davide , Degregori Ginevra
Published: September 2023

This paper provides a structured literature review (SLR) on new emerging technologies supporting the Environmental, Social and Governance aspects (ESG) to identify the interdependencies and relationships between these two areas. Using a rigorous methodological approach, the study summarises the state of the art of the past literature on the topic, which has grown significantly in importance in recent years. The analysis has been conducted on 204 papers extracted from the Scopus database using the Blibliometrix R package. Additionally, using the SLR road, we provide a bibliometric and coding analysis focused on papers published in different academic journals in the business management and accounting field. Our results discover three strands of research: new emissions control technologies, new sustainability assessment management technologies, and disruptive energy management technologies. These results demonstrate the originality of the paper that resides in a novel analysis concerning the recent role played by innovation technologies in sustainability. The study reveals the need for more holistic research and an integrated framework that consider the technological aspects related to ESG criteria, and not consider the two separately as in the present literature. Related to that, there is also the demand for a deeper exploration about the role that new technologies play in the various sustainability initiatives. Finally, the article addresses future research perspectives and paths as joint scholars and practitioners' analysis.
Virtual(-only) shareholders' meetings in Italian listed companies: quo vadis?
Authors: Raffaele Federico
Published: September 2023

The article focuses on the legacy, if any, once the pandemic crisis is over, of the Italian emergency legislation re: the participation in the shareholders' meeting by means of telecommunications, with particular attention to the regulation of listed companies. Specifically, the topic of virtual(-only) meetings is addressed with a view both to investigating the reasons for their scarce use by Italian listed issuers, and to understanding whether the ability to intervene remotely can become a default rule in Italy. To this end, after analyzing the peculiarities of the Italian legal system – which, de facto, have limited the "virtualization" of the meetings, given that, inter alia, in the absence of a specific express provision in the by-laws, a virtual-only meeting appears not to be admissible under Italian law –, possible solutions de lege ferenda that may justify a "generalized" regime of virtual meetings in the Italian system will be illustrated.
Psicopatologia della Situazione: le radici fenomenologiche e umanistiche del testo curato da Margherita Spagnuolo Lobb e Pietro A. Cavaleri. Prefazione all'edizione inglese
Authors: D. Churchill Scott
Published: September 2023

L'articolo è la prefazione all'edizione inglese del volume "Psicopatologia della Situa-zione" curato da Margherita Spagnuolo Lobb e Pietro A. Cavaleri. L'obiettivo dell'autore, Scott D. Churchill, è di invitare alla lettura di questo testo che rappresenta un interessante contributo di rinnovamento delle idee classiche della psicoterapia della Gestalt. Nel libro viene sottolineato il cambiamento in atto nel pensiero della Gestalt che, dalle sue fonda-menta più classicamente intese come "centrate sul cliente", nel tempo si è orientata sempre più verso una focalizzazione sull'incontro stesso come terreno primario per la compren-sione e il cambiamento psicoterapeutico. L'autore approfondisce il concetto di "situazione" rivisitando il pensiero dei fenomenologi, Heidegger e Sartre.
Le politiche monetarie italiane nel Benadir tra incognite, errori e resistenze (1893-1909)
Authors: Sessa Claudio
Published: September 2023

L'articolo prende in esame l'evoluzione delle politiche monetarie italiane nel Benadir nel pe- riodo coloniale compreso tra il 1893 e il 1909. A partire dalla ricostruzione della circolazione monetaria dei territori benadiriani, viene analizzato il difficile e complesso approccio del governo coloniale alla situazione monetaria locale. In modo particolare, vengono ricostruiti e analizzati i principali interventi in campo monetario da parte degli amministratori italiani e le strategie di resistenza poste in essere dalle popolazioni locali.
"Un comune sentimento di umana solidarietà". Il soccorso all'infanzia nella casa degli italiani di Saint-Cergues Les Voirons (1928-1945)
Authors: Montella Fabio
Published: September 2023

La costruzione di un edificio da utilizzare come colonia estiva per i figli degli emigrati ita- liani, a Saint-Cergues Les Voirons, nei pressi di Ginevra, fu considerata dagli esuli antifa- scisti come una delle loro migliori imprese durante gli anni della dittatura. Sebbene esista- no importanti studi sui fuorusciti italiani in Svizzera e in Francia, la vicenda è stata quasi del tutto ignorata dalla storiografia italiana e soltanto da pochi anni ha iniziato a essere og- getto di studio in relazione al ruolo svolto per la salvezza di bambini ebrei. Luogo di prote- zione dai condizionamenti della dittatura fascista, dagli orrori della guerra civile spagnola, dalla tragedia del secondo conflitto mondiale e della Shoah, la casa di Saint-Cergues (inau- gurata nel 1933) rappresenta una sorta di paradigma della storia ambivalente dell'infanzia nel corso del Novecento: sempre più coinvolta nei conflitti armati e nella violenza e allo stesso tempo oggetto di un'attenzione specifica e di crescenti sistemi di protezione naziona- le e internazionale.
Sviluppo, finanza pubblica e partitocrazia: le tre "facce" della questione morale di Berlinguer
Authors: Zampieri Chiara
Published: September 2023

Ripercorrendone la genesi e l'evoluzione nel corso degli anni Settanta e Ottanta, il saggio propone una rilettura originale del pensiero di Enrico Berlinguer sulla "questione morale". L'autrice mette in luce come la "questione morale" non riguardasse solamente il problema della corruzione dei partiti, ma investisse anche altri piani di analisi spesso trascurati. Il pri- mo riguarda la questione della divisione fra Nord e Sud del mondo e la crisi del modello di sviluppo capitalistico a fronte della quale Berlinguer propose una nuova "etica dello svilup- po". Il secondo riguarda la crisi del governo pubblico dell'economia e il problema della spe- sa pubblica, la cui dimensione per Berlinguer assunse la rilevanza di un problema "morale". Il terzo piano investe la "partitocrazia", cioè l'occupazione dello Stato da parte dei partiti. Su questo nodo l'autrice propone una riflessione che inquadra il discorso berlingueriano nel cre- scente clima di antipolitica che avrebbe caratterizzato tutti gli anni Ottanta mettendone in ri- levo le analogie e le differenze con il sentimento antipolitico odierno e di allora.
Corpi che sognano: le rêverie sensoriali alla luce del dialogo tra psicologia analitica e le neuroscienze
Authors: Battipaglia Mariella , Curatola Giovanna
Published: September 2023

L'articolo esplora alcuni aspetti della clinica del trauma nelle loro intersezioni tra la teoresi junghiana e le neuroscienze nella cornice dell'intersoggettività. Tradizionalmente la psicoanalisi ha posto l'accento sulle parole, le interpretazioni, il dare senso, ma recentemente c'è una maggiore riflessione sugli aspetti affettivi, relazionali e incarnati del lavoro terapeutico e del modo in cui questi si riferiscono all'esperienza traumatica interattiva precoce che si svolge al di fuori della consapevolezza. Vengono considerati anche alcuni dei modi in cui la conoscenza di particolari sistemi di connettività informa la comprensione dell'intera relazione mente-cervello-corpo. Le autrici, nel presentare un frammento di esperienza clinica, mettono soprattutto in luce alcune riflessioni sui fenomeni corpo-mente e sulle rêverie sensoriali che si verificano nella seduta analitica, cercando di osservarli con una doppia lente interdi­sciplinare che permette di rendere pensabile il "cervello-corpo-mente in relazione", descritto dalle neuroscienze e da Jung nella psicologia analitica complessa, assegnando alla affettività il ruolo di organizzatore delle rappresentazioni inconsce e della spinta verso l'emersione alla coscienza.
Doxastic managerial practice and management of the market economy
Authors: Bran Florina , I. Gâf-Deac Ioan , Radulescu Carmen-Valentina , Crizantema Vîlcu (Tanase) Elena , Burlacu Sorin , Loredana Popescu Maria , Alexandru Bodislav Dumitru
Published: September 2023

In the article we examined the plan for advanced concern about human perceptu-al horizons, based on deeper knowledge, to prove the faith in organization and management. In particular, we explored the premises of doxometric management, plausibility structures in relation to static or dynamic doxastic managerial attitudes to build neighborhood structures to increase decision confidence. We believe that in the first quarter of the 21st century it is not so much historical events, the Inter-net or electronic commerce, or technology in general that determine societal influ-ences and changes, but rather knowledge management. There have been and are unprecedented changes in the human condition. It is possible, from a sociological perspective, to show the end of modernity considering that managers and people, in general, those in developed Western societies, in particular, have already come under a strong rationality. No one dares to conceptually touch the market econo-my. We come to the conclusion that a new type of management is needed. It is about doxastic organization and leadership, by measuring trust and opening the borders of neighborhood structures.
Protection of privacy in information technologies in the context of COVID-19: A comparative legal analysis of the Republic of Kazakhstan and the European Union
Authors: Kubenov Gizat , K. Zhetpisov Serik , A. Alibayeva Gulnar , Yu. Kolesnikov Yuriy , K. Kydralinova Ainash
Published: September 2023

Today, the world community faces the arduous and responsible task of preventing the spread of the coronavirus disease COVID-19, which objectively requires the adoption of a complex of anti-epidemic (organizational, medical, administrative, and other) measures to prevent the spread of COVID-19 and to contain and elimi-nate this epidemic. At the same time, to a large extent, such measures are embod-ied in various forms of restrictions on the realization of civil, political, and other rights, freedoms, and legitimate interests of a person and a citizen, as well as to a certain extent there are encroachments on the inviolability of a person's private life. The purpose of the scientific article is to study the state mechanisms of Ka-zakhstan and the European Union on legal support and security of personal data on the Internet, particularly during the COVID-19 pandemic, and to determine possible ways for their development and improvement. The research used dialecti-cal, historical-legal, formal-logical, comparative-legal, and special-legal research methods, and systemic-structural research methods, as well as the method of sys-temic analysis. The theoretical significance of the study lies in the fact that it de-velops new scientific provisions, proposals, and recommendations that deepen the theoretical and practical foundations in the field of legal regulation of personal da-ta protection in information technologies during the pandemic in the European Un-ion in general and in the Republic of Kazakhstan in particular.
SOCIALIZATION OF MANUAL AND ELECTRONIC MEDICAL RECORD SYSTEMS AT PUSKESMAS SEI. NANAM SOLOK REGENCY
Authors: Kamal Syamsul , Mardi Yuli , Prihatin Endang
Published: September 2023

The use of the Electronic Medical Record System (RME) in health service facilities is a need and demand carried out by health workers, which is related to Permenkes No. 24 of 2022, that RME has been used before December 31, 2023, in all Health Service Facilities. At the Sii Health Center. Nanam Kab. Solok, medical record activities are still carried out manually. The problem is that medical record staff do not understand electronic medical records which will be implemented in health care facilities throughout Indonesia. Once the importance of RME, RME Socialization, and the Manual Medical Record System was carried out at the Sei Health Center. Nanam Kab. Solok on September 22, 2022, there were 12 participants, namely dr, P-Care Health Center, and medical record staff at Sei Health Center. Nanam Kab. Solok and student Apikes Iris. During this socialization, it was explained to participants of the RME system, Manual Medical Record (RMM), Legal Basis for Medical Records, advantages and disadvantages of manual and electronic RME systems, Obstacles and challenges of RME, participants who attended the socialization listened to information with enthusiasm and enthusiasm, in elaborating on this material, some asked questions and discussions who did not understand Manual and Electronic Medical Records. The purpose of this activity is to make the puskesmas staff, especially the medical record department, understand and understand RME and RMM.
Estadística
Authors:   Universidad de Guadalajara, Expresión Económica Equipo
Published: September 2023

Estadística
El debate de la ciencia económica: aportes para su discusión.
Authors:   Universidad de Guadalajara, Ramirez Martinez Marcos Antonio , Lopez Delgadillo Jaime ,   Universidad de Guadalajara
Published: September 2023

El debate de la ciencia económica: aportes para su discusión.
Caracterización general de la economía mexicana y restricción del sector externo
Authors:   UAM Azcapotzalco, De la Rosa Mendoza Juan Ramon
Published: September 2023

Caracterización general de la economía mexicana y restricción del sector externo
Fuentes de Información
Authors:   Universidad de Guadalajara, Expresión Económica Equipo
Published: September 2023

Fuentes de Información
Perspectivas económicas para México en la transición política
Authors:   Universidad de Guadalajara, Sandoval Cabrera Pablo
Published: September 2023

Perspectivas económicas para México en la transición política
Cap. 1 ¿Por que importa el sistema de salud?
Authors:   Universidad de Guadalajara, Expresión Económica Staff
Published: September 2023

Cap. 1 ¿Por que importa el sistema de salud?
La función directiva escolar y el liderazgo
Authors:   Universidad de Guadalajara, Alvarado Castellanos Teresita de Jesus
Published: September 2023

La función directiva escolar y el liderazgo
La dinámica del regionalismo en el Pacífico asiático
Authors:   Universidad de Guadalajara, Mackintosh Ramírez Antonio
Published: September 2023

La dinámica del regionalismo en el Pacífico asiático
Quality and Organizational Innovation: Competitiveness Tools in the Table Grape System
Authors: Maycotte de la Peña Mayra Lucía , Montaño Silva Karen , Robles Parra Jesús Martín , Paz-Luna Jesús Lauro
Published: September 2023

The research seeks to analyze quality management strategies as organizational innovation practices incorporated by table grape-producing organizations and their relationship with competitiveness. The data was obtained by elaborating a semi-structured interview script, which was applied to the managers or responsible people of the Sonoran table grape-producing organizations. The results allow us to recognize the main innovations organizations incorporate, specifically those related to organizational innovation. It was concluded that quality and organizational innovation are considered essential practices to generate competitive advantages in organizations since they generate knowledge, learning, and skills that drive decision-making aimed at business success.
Is There a Link Between Sleep Quality and a Tendency for Eating Disorders?
Authors: Çiftçi Seda , Kızıl Merve
Published: September 2023

Aim: Poor sleep quality has been associated with an increased risk of developing eating disorders, and unhealthy eating behaviours. The aim of the study was to explore the potential link between sleep quality and eating disorders.
Subjects and Method: This descriptive, observational, and cross-sectional study was conducted with 357 (84 male; 273 female) university students between the ages of 18-25 years. Exclusion criteria included being diagnosed with chronic disease and psychiatric disorders, being pregnant and lactating, using drugs that affect sleep patterns, being shift workers, and participants who did not complete the questionnaire. The questionnaire consisted of six parts including Pittsburgh Sleep Quality Index (PSQI), Three-Factor Eating Questionnaire (TFEQ-21), SCOFF (REZZY) Eating Disorders Scale, anthropometric measurements, demographic properties, and nutritional habits.
Results: The prevalence of poor sleep quality was found to be 63% and there was no significant difference between gender in terms of sleep quality (p=0.769). There was significant relationship between total TFEQ 21 (p=0.02), SCORF (REZZY) (p<0.001) scores and sleep quality. Uncontrolled eating behaviours was found higher in students with poor sleep quality (p<0.05). Age, body mass index (kg/m2), and smoking were not significant predictors of sleep quality. However, participants with a tendency towards eating disorders behaviour were found to have a significantly higher risk of poor sleep quality (odds ratio [OR]: 2.338, 95% confidence interval [CI]: 1.444-3.785, p=0.001), as were those with a tendency towards emotional eating behaviour (OR: 1.575, 95% CI: 1.022-2.427, p=0.040).
Conclusion: Students with poor sleep quality had higher levels of uncontrolled eating behaviour and a tendency towards unhealthy eating attitudes than those with good sleep quality.
Pharmacological therapeutic appliance for acute poisoning by organophosphorous compounds of anticholinesterase action (review of literature)
Authors: Zinovieva M.L. , Kurdil N.V. , Zhminko P.G. , Prodanchuk M.G. , Kravchuk O.P. , Velychko M.V.
Published: September 2023

The current standards of treatment the acute OPC poisoning with anticholinesterase action remain insufficient, despite the significant number of researches in this area conducted in the world. One of the ways to solve this problem is to use a wider range of pathogenetically determined pharmacologic agents. The Aim of the Research. To observe and summarize the published results of investigation the pharmacological therapeutic appliance for acute OPC poisoning at the stages of preclinical and early clinical evaluation. Methods. System content analysis of literature data using the PubMed and Google Scholar databases. Results and Conclusions. The investigation of pharmacological therapeutic appliance effectiveness for acute anticholinesterase OPC poisoning remains relevant when taking into account the complexity of the intoxication pathogenesis. The main lines of pharmacological agents’ research for the acute anticholinesterase OPC poisoning include the study of n-cholinoreceptor antagonists, benzodiazepine receptor agonists, NMDA-receptor antagonists, H1-histamine receptor antagonists, alpha-adrenergic receptor agonists, enzymatic antidote, antioxidants, agonists of beta-adrenergic blockers, and also magnesium sulfate, sodium bicarbonate, lipid emulsions. The investigations of clinically available therapeutic appliance continue both in animal experiments and at the clinical application stage. Such investigations are also important given the need for poisoning emergency care under conditions when specific therapies are missing or limited. Keywords: organophosphorus compounds, acute poisoning, therapeutic appliance.
Assessment of systemic and organotoxic effects caused by the modern synthetic opioids: clinical and forensic aspects
Authors: Kurdil N.V. , Voroshylov K.F. , Rozhkova O.N. , Voitenko M.Yu. , Novostroina P.S. , Rozovyk I.V.
Published: September 2023

ABSTRACT. Establishing the cause of death in modern drug poisonings (overdoses) is not always a simple task. The systemic toxic effects resulting from the consumption of opioid drugs of the new generations are extremely diverse and extend far beyond the nervous system. The causes of death and mechanisms of tonatogenesis are also quite diverse, so their establishment is based on a wide range of data that can be obtained both during life and in the process of forensic research.

Aim. Analysis of the causes of death due to drug poisoning (opioids-related) in adults according to the data of clinical and pathohistological studies.

Materials and Methods. A retrospective analysis of the medical records of 164 patients who died in the hospital as a result of opioid poisoning during the period 2017–2021 was carried out; analyzed the data of sectional and microscopic studies of tissues (lungs, kidneys, myocardium, brain, liver, spleen) of 28 people with drug overdoses involving opioids who died outside hospitals during the same period. The preparations were examined using an Olympus CX 41 microscope in transmitted light, at magnifications of 40, 100, and 400 times.

Results. Clinical, functional and laboratory tests carried out in the hospital's admissions department and in the intensive care unit revealed the following pathological conditions: cerebral coma, brain edema – 158 (96.3 %); respiratory failure – 73 cases (44.5 %); liver failure – 23 (13.4 %); kidney failure, including anuria – 14 (8.5 %); syndrome of prolonged compression of soft tissues and rhabdomyolysis – 9 (5.4 %); cardiopulmonary failure, including pulmonary edema – 19 (11.5 %); the presence of thrombophlebitis, purulent wounds, sepsis – 24 (14.6 %). According to examination data, toxicological anamnesis, and information from patients' relatives, the structure of concomitant pathology was determined in accordance with ICD-10 codes. According to the data of sectional and histological studies, in 89 cases (54.2 %), changes characteristic of a systemic inflammatory reaction and a chronic inflammatory process, including sepsis, were detected. The results of clinical and pathohistological studies show that drug users have various concomitant pathologies of many organs and systems (lungs, heart, liver, kidneys, etc.), which increases the toxic effect of drugs and conditions the features of tonatogenesis.

Conclusions. The study of clinical and histological parallels in cases of sudden death due to drug overdoses will allow us to increase the level of our knowledge about the mechanisms of tonatogenesis and contribute to the determination of effective measures to prevent premature mortality of the population.

Keywords: drugs, overdose, mortality, lethality, forensic medicine.
Integration of Technology into Science Teaching: A Phenomenological Study on the Experiences of the Pre-service Teachers
Authors:   Department of Science Education, Faculty of Education, Kastamonun University, Turkey, Memiş Esra Kabataş , Et Sümeyra Zeynep ,   Department of Measurement and Evaluation in Education, Faculty of Education, Fırat University, Turkey, Sönmez Elif ,   Department of Primary Education, Faculty of Education, Kastamonu University, Turkey
Published: September 2023

Improvements in science and technology have led to changes in education as well as in many other fields. These changes have made it necessary for today’s individuals to have a set of skills in different fields. One of these fields is technology-related skills. Learning environments that require the use of technology undoubtedly play a key role in raising individuals with technological skills. In this direction, the aim of this research is to study the experiences of pre-service science teachers related to the use of technology within the scope of a course. In this qualitative research, a phenomenological methodology was used to reveal the understandings of preservice science teachers on the experience of integrating technological applications into science teaching. In this context, in-depth semi-structured interviews were conducted with 10 pre-service teachers, about their experiences. As a result of the inductive content analysis, the following four themes, which reflect how the participants interpret the integration of technology in science teaching, were determined in line with the experiences of the participants: The technological tools used in the learning environment and why they are preferred, the necessity of the technological knowledge in the teaching profession, the necessity of the use of technology in the learning environment, and the characteristics of a qualified teacher. Based on the results, the practices for teacher education in the integration of technology in science teaching were discussed.
The Impact of a Policy Designed to Promote Systemic Change Related to Promotion and Tenure Decisions in STEM Promotion and Tenure Decisions
Authors:   Department of Middle and Secondary Education, Georgia State University, Atlanta, Georgia, USA, Demir Kadir , Criswell Brett ,   Department of Secondary Education, West Chester University, West Chester, Pennsylvania, USA
Published: September 2023

This research study focused on understanding changes that were taking place in Promotion and Tenure (P and T) practices in eight selected institutions of higher education in the state of Georgia and examined factors, if any, that were acting as a catalyst for change. The research team used both quantitative and qualitative analyses of the P and T dossier reviews. The study did broaden our understanding of important and complex issues in higher education. The results have implications for higher education faculty and administrators as they contemplate tenure and promotion decisions and policies, and complete future research studies.
The old friends hypothesis: evolution, immunoregulation and essential microbial inputs
Authors: Rook Graham A. W.
Published: September 2023

In wealthy urbanised societies there have been striking increases in chronic inflammatory disorders such as allergies, autoimmunity and inflammatory bowel diseases. There has also been an increase in the prevalence of individuals with systemically raised levels of inflammatory biomarkers correlating with increased risk of metabolic, cardiovascular and psychiatric problems. These changing disease patterns indicate a broad failure of the mechanisms that should stop the immune system from attacking harmless allergens, components of self or gut contents, and that should terminate inappropriate inflammation. The Old Friends Hypothesis postulates that this broad failure of immunoregulation is due to inadequate exposures to the microorganisms that drive development of the immune system, and drive the expansion of components such as regulatory T cells (Treg) that mediate immunoregulatory mechanisms. An evolutionary approach helps us to identify the organisms on which we are in a state of evolved dependence for this function (Old Friends). The bottom line is that most of the organisms that drive the regulatory arm of the immune system come from our mothers and family and from the natural environment (including animals) and many of these organisms are symbiotic components of a healthy microbiota. Lifestyle changes that are interrupting our exposure to these organisms can now be identified, and many are closely associated with low socioeconomic status (SES) in wealthy countries. These insights will facilitate the development of education, diets and urban planning that can correct the immunoregulatory deficit, while simultaneously reducing other contributory factors such as epithelial damage.
Comparison of laparoscopic sacrocolpopexy with vaginal reconstructive procedures and abdominal sacrocolpopexy for the surgical management of vaginal vault prolapse: a systematic review and meta-analysis
Authors: Ciortea Răzvan , Roman Maria-Patricia , Măluțan Andrei Mihai , Bucuri Carmen Elena , Ormindean Cristina Mihaela , Nati Ionel Daniel , Mihu Dan
Published: September 2023

Introduction

Vaginal vault prolapse, also known as apical prolapse, is a distressing condition that may affect women following hysterectomy, necessitating surgical intervention when conservative measures prove ineffective. The surgical management of apical compartment prolapse includes procedures such as laparoscopic sacrocolpopexy (LSCP), abdominal sacrocolpopexy (ASCP) or vaginal reconstructive procedures (VRP). This systematic review and meta-analysis aims to compare the outcomes of these interventions.

Methods

A comprehensive search of electronic databases was conducted to identify eligible studies. Fourteen studies comprising a total of 1,289 women were included. The selected studies were analyzed to evaluate outcomes such as duration of surgery, length of hospital stay, blood loss, complication rates, and patient satisfaction.

Results

LSCP did not demonstrate significant advantages over VRP in terms of perioperative or long-term outcomes. However, when compared to ASCP, LSCP showed shorter hospital stay, reduced blood loss, decreased postoperative pain, and lower rates of ileus.

Discussion

This systematic review contributes to evidence-based decision-making for the surgical treatment of vaginal vault prolapse. While LSCP did not exhibit substantial benefits over VRP, it emerged as a preferable option compared to ASCP due to shorter hospital stays and reduced postoperative complications. The findings from this study provide valuable insights for clinicians and patients in selecting the most appropriate surgical approach for vaginal vault prolapse. However, future research should focus on long-term follow-ups, standardizing outcomes, and outcome measures, and evaluating cost-effectiveness to further enhance clinical practice.
Neurodegeneration and its potential markers in the diagnosing of secondary progressive multiple sclerosis. A review
Authors: Pogoda-Wesołowska Aleksandra , Dziedzic Angela , Maciak Karina , Stȩpień Adam , Dziaduch Marta , Saluk Joanna
Published: September 2023

Approximately 70% of relapsing-remitting multiple sclerosis (RRMS) patients will develop secondary progressive multiple sclerosis (SPMS) within 10–15 years. This progression is characterized by a gradual decline in neurological functionality and increasing limitations of daily activities. Growing evidence suggests that both inflammation and neurodegeneration are associated with various pathological processes throughout the development of MS; therefore, to delay disease progression, it is critical to initiate disease-modifying therapy as soon as it is diagnosed. Currently, a diagnosis of SPMS requires a retrospective assessment of physical disability exacerbation, usually over the previous 6–12 months, which results in a delay of up to 3 years. Hence, there is a need to identify reliable and objective biomarkers for predicting and defining SPMS conversion. This review presents current knowledge of such biomarkers in the context of neurodegeneration associated with MS, and SPMS conversion.
The multifaceted roles of matrix metalloproteinases in lung cancer
Authors: Wei Cui
Published: September 2023

Background

Though the matrix metalloproteinases (MMPs) are widely investigated in lung cancer (LC), however, almost no review systematically clarify their multi-faced roles in LC.

Methods

We investigated the expression of MMPs and their effects on survival of patients with LC, the resistance mechanisms of MMPs in anti-tumor therapy, the regulatory networks of MMPs involved, the function of MMPs inducing CSCLs, MMPs-related tumor immunity, and effects of MMP polymorphisms on risk of LC.

Results

High expression of MMPs was mainly related to poor survival, high clinical stages and cancer metastasis. Role of MMPs in LC are multi-faced. MMPs are involved in drug resistance, induced CSCLs, participated in tumor immunity. Besides, MMPs polymorphisms may increase risk of LC.

Conclusions

MMPs might be promising targets to restore the anti-tumor immune response and enhance the killing function of nature immune cells in LC.
Copper homeostasis and cuproptosis in tumor pathogenesis and therapeutic strategies
Authors: Bian Chenbin , Zheng Zhuangzhuang , Su Jing , Chang Sitong , Yu Huiyuan , Bao Jindian , Xin Ying , Jiang Xin
Published: September 2023

Copper is an indispensable micronutrient for the development and replication of all eukaryotes, and its redox properties are both harmful and beneficial to cells. An imbalance in copper homeostasis is thought to be involved in carcinogenesis. Importantly, cancer cell proliferation, angiogenesis, and metastasis cannot be separated from the effects of copper. Cuproposis is a copper-dependent form of cell death that differs from other existing modalities of regulatory cell death. The role of cuproptosis in the pathogenesis of the nervous and cardiovascular systems has been widely studied; however, its impact on malignant tumors is yet to be fully understood from a clinical perspective. Exploring signaling pathways related to cuproptosis will undoubtedly provide a new perspective for the development of anti-tumor drugs in the future. Here, we systematically review the systemic and cellular metabolic processes of copper and the regulatory mechanisms of cuproptosis in cancer. In addition, we discuss the possibility of targeting copper ion drugs to prolong the survival of cancer patients, with an emphasis on the most representative copper ionophores and chelators. We suggest that attention should be paid to the potential value of copper in the treatment of specific cancers.
Improvement of the Integral Indicator of the Ecological and Toxicological Assessment of the Danger of the Use of Pesticides in Agriculture and the Creation of an Information System for Their Monitoring
Authors: Slastya Irina , Khudyakova Elena , Vasenev Ivan , Benin Dmitrii , Stepantsevich Marina , Vodjannikov Vladimir , Nikanorov Mikhail , Fomina Tatiana
Published: September 2023

The aim of the work was to assess the ecological and toxicological dangers of pesticides using the value of a complex indicator determined by the calculation method. An integral indicator of the relative ecological and toxicological danger of pesticide use (Hr) is proposed, which allows taking into account the acute oral and chronic toxicity of the pesticide for mammals and its impact on the environment (half-life in soil and chronic toxicity for aquatic organisms), as well as the rate of application of the drug. The computation was performed on fungicides and insecticides that are most commonly used in grain crop cultivation and approved to be applied in the Russian Federation. The research was carried out in 2022–2023. The results showed that the determined indicator takes values from 0.02 for the fungicide benomyl to 26950 for the insecticide chlorpyrifos. Pesticides were ranked according to the Hr index, and four hazard groups were identified, as well as the main factors that determine them. The first hazard group should include drugs with a Hr greater than 1000; the second hazard group—with Hr from 100 to 1000; the third—with Hr from 1 to 100; and the fourth—with Hr less than 1. The first group includes pesticides with multiple adverse safety profiles, such as chlorpyrifos. The second group includes insecticides fipronil, lambda-cyhalothrin, gamma-cyhalothrin, imidacloprid and the fungicide flutriafol. The indicator can be used for agro-ecological substantiation of the choice of pesticides for the treatment of agricultural crops and for the selection of priority pesticides for regular monitoring of their content in the environment—primarily the first and second hazard groups. It can be performed remotely by appropriate detectors and sensors. All data about farm pollution can be monitored using an information server monitoring system, the architecture of which has been proposed.