bluuebunny/crossref_metadata_2025 huggingface dataset:
3D Printing of β-TCP/S53P4 Scaffolds: Physicochemical, Mechanical, and Biological in vitro Evaluation
Authors: Alves Ana P.N. , Barbosa Lucas , Oliveira Rodrigo L.M.S. , Oliveira Julia Andrade de , Alves Mariana de Sá , Vasconcellos Luana Marotta Reis de , Trichês Eliandra de S.
Published: June 2023

Abstract: The focus of bone tissue engineering is on the new strategies for developing bioactive and resorbable scaffolds, which have become an alternative to the treatment of bone diseases and trauma. β-tricalcium phosphate (β-TCP) is considered resorbable and has excellent osteoconductivity. In an attempt to achieve good densification of the β-TCP scaffold and improve its biological properties, it arises the possibility of combining this material with S53P4 bioactive glass. Several techniques are used to produce bioceramic scaffolds, among them, direct ink writing (DIW) a type of additive manufacturing based on material extrusion, which allows the production of customized parts, with high complexity and good reproducibility. This work prepared β-TCP and β-TCP/S53P4 (β-TCP/10-S53P4 = 10% wt of S53P4 and β-TCP/20-S53P4 = 20% wt of S53P4) scaffolds by DIW. The ceramic inks showed pseudoplastic behavior and the 3D-printed scaffolds showed similar aspects to the digital model. Also, the β-TCP/S53P4 scaffolds (β-TCP/10-S53P4 = 1.6 ± 0.6 MPa and β-TCP/20-S53P4 = 2.1 ± 0.9 MPa) showed an increase in compressive strength when compared to β-TCP scaffolds (0.9 ± 0.1 MPa). All scaffolds showed apatite-mineralization ability in SBF after soaking for 7 and 14 days, being that the β-TCP/20-S53P4 scaffold showed a higher ability of apatite formation compared to the other scaffolds. Concerning the biological in vitro assays, all the scaffolds showed good cell viability. Thus, the β-TCP/S53P4 scaffolds showed adequate properties which become them, good candidates, to be used in bone tissue engineering.
PENGEMBANGAN MODEL LOYALITAS MAHASISWA BERBASIS PENGALAMAN BELAJAR (STUDI PADA MAHASISWA STIE SE KOTA SEMARANG)
Authors: Suhaji Suhaji , Widiastuti Tantri , Bodroastuti Tri
Published: June 2023

Tujuan utama penelitian ini adalah untuk menguji hubungan antara pengalaman mahasiswa (pengalaman akademik dan non akademik), terhadap loyalitas mahasiswa dan mendeskripsikan pengaruh kepuasan mahasiswa sebagai variabel mediator dalam model loyalitas mahasiswa. Model ini diuji menggunakan model persamaan struktural dengan software PLS (Partial Lease Square). Data empiris diambil dari 8 Sekolah Tinggi Ilmu Ekonomi (STIE) di Kota Semarang, Jawa Tengah. Metode pengumpulan data yang digunakan adalah metode angket dengan teknik sampling strata bertahap. Analisis data dilakukan dengan statistik deskriptif dan model persamaan struktural untuk menguji model hipotesis. Hasil penelitian menunjukkan bahwa kepuasan mahasiswa dan dua variabel anteseden: Pengalaman Akademik, dan Pengalaman Non Akademik berpengaruh positif terhadap loyalitas mahasiswa dengan tingkat signifikansi sebesar 0,05.
Dampak Kepemilikan Institusional Domestik terhadap Penghindaran Pajak: Peran Thin Capitalization Sebagai Pemoderasi
Authors: I Michelyne Ayuthaya , Simbolon Richard F.
Published: June 2023

Ketidakkonsistenan hasil penelitian mengenai variabel yang mempengaruhi penghindaran pajak dari peneliti sebelumnya menunjukkan bahwa terdapat faktor lain yang turut mempengaruhi penghindaran pajak. Penelitian ini bertujuan untuk menganalisis dan membuktikan pengaruh kepemilikan institusional domestik dan thin capitalization terhadap penghindaran pajak pada perusahaan sektor pertambangan. Untuk menentukan sampel, peneliti menggunakan metode purposive sampling dari data perusahaan yang terdaftar di www.idx.com periode 2018-2019. Analisis dilakukan dengan menggunakan SPSS versi 25 melalui uji statisik deskritif, uji asumsi klasik, dan pengujian hipotesis. Peneliti menemukan bahwa kepemilikan institusional domestik berpengaruh negatif terhadap penghindaran pajak. Selanjutnya, thin capitalization terbukti memperkuat pengaruh sebagai variabel moderasi terhadap penghindaran pajak.
Proyeksi Dinamika Pendapatan Asli Daerah Nusa Tenggara Barat
Authors: Zulkieflimansyah Zulkieflimansyah , Nurjihadi Muhammad , Hasri Diah Anggeraini , Ananda Nova Adhitya , Hakim Lukmanul
Published: June 2023

Pendapatan Asli Daerah (PAD) merupakan salah satu sumber pembiayaan pembangunan daerah dalam masa otonomi daerah. Sumber PAD adalah pajak daerah, retribusi daerah, hasil pegelolaan kekayaan daerah yang dipisahkan, dan lain-lain PAD yang sah. Penelitian ini bertujuan untuk memberikan rekomendasi untuk pemerintah dalam merencanakan target penerimaan PAD. Penelitian ini merupakan penelitian kuantitatif dengan menggunakan pendekatan system dinamik dan analisis time series seperti model linear, quadratic, exponential-growth dan s-curve dalam membuat model proyeksi penerimaan PAD di Provinsi NTB. Pada pemodelan system dinamik, penentuan faktor yang mempengaruhi berasal dari variabel tax base seperti jumlah kendaraan, mutasi, tarif dan tingkat pembayaran PKB. Berdasarkan hasil penelitian dengan pendekatan system dinamik diperoleh bahwa kenaikan 1% tingkat pembayayaran wajib pajak kendaraan bermotor roda dua, dapat meningkatkan 1% PAD, sedangkan untuk kendaraan lainnya meningkatkan 2% PAD. Pendekatan time series menghasilkan bahwa model terbaik dalam memproyeksi PAD adalah dengan menggunakan model linear, sedangkan komponen PAD lain menggunakan model S-Curve untuk pajak daerah, retribusi daerah menggunakan exponential-growth dan HPKDY serta lain-lain PAD yang sah menggunakan model quadratic. Penggunaan system dinamik dan time series menghasilkan dinamika proyeksi PAD memiliki tren yang menaik.
PENGARUH BOOK TAX DIFERRENCE YANG DIUKUR DENGAN FIXED ASSETS, SALES GROWTH DAN DEFERRED TAX EXPENSE TERHADAP TAX AVOIDANCE
Authors: Indriani Ida
Published: June 2023

The purpose of this study is to find out how Book Tax Difference as measured by the ratio of Fixed assets, Sales growth and Deffered tax expenses affects the possibility of Tax avoidance in Manufacturing companies listed on the Indonesia Stock Exchange for the period 2019 – 2021. The research method used is a descriptive research method and verification analysis.The population in this study consisted of manufacturing companies listed on the Indonesia Stock Exchange. Sampling in this study was carried out by purposive sampling technique. There are 14 manufacturing companies that meet the criteria to be used as research samples.The analytical method used is Multiple Linear Regression analysis. Based on the results of the study using analysis of the coefficient of determination, it shows that partially the variable that has the most influence on the Tax avoidance variable is the Sales Revenue variable (X2) of 15.4% and followed by the Deffered tax expense variable of (X3) of 15.1% and the Fixed variable Assets (X1) of 13.1%. Thus the overall effect is 43.6% while the remaining 56.4% is contributed by variables other than Fixed assets, Sales growth, and Deffered tax expenses. Based on the output results using SPSS 16.0, the coefficient of determination can be obtained, which is equal to 0.436. This means that simultaneously Fixed assets (X1), Sales growth (X2), and Deffered tax expenses of (X3) affect Tax avoidance (Y) of 43.6 % while the remaining 56.4% is influenced by other factors not examined in this study.
PENGARUH FINANCIAL KNOWLEDGE, FINANCIAL ATTITUDE DAN INTERNAL LOCUS OF CONTROL TERHADAP FINANCIAL MANAGEMENT BEHAVIOR PADA PELAKU UMKM KOTA SURAKARTA
Authors: Sheda Ghegana Ariel
Published: June 2023

This study aims to analyze (1) financial knowledge, (2) financial attitude and (3) internal locus of control on personal financial management behavior in Small and Medium Enterprises in Surakarta City. The population in this study were MSME Entrepreneurs in the Online Shop Marketplace in Surakarta City and the sample in this study amounted to 80 MSMEs in the Online Shop field, the method used was purposive sampling. Based on the results of the t test, financial knowledge does not have a significant effect on financial management behavior in Online Shop MSME actors. The indicators of financial attitude and internal locus of control have a significant influence on the financial management behavior of Online Shop MSME actors. The results of this research can be used as input and reference material for SMEs in overcoming obstacles to financial management when running their entrepreneurship.
COMPARISON OF FACTORS AFFECTING THE LEVEL OF FRAUD IN LQ-45 INDEX CORPORATE FINANCIAL REPORTS
Authors: Amsaroka Muhamad Hayan
Published: June 2023

This research intends to identify the possibility what companies listed on LQ 45 Index will commit the fraudulent financial statement after the Covid-19 pandemic. In addition, the research aims to assign the most influential account will commit in fraudulent financial statement. In this research, Companies listed on the LQ 45 Index in 2020 and 2021 were selected be the sample for this research, and financial reporting from 2020 and 2021 was collected. Using the Beinish Model M-Score, sample was divided into two groups, namely manipulators and non-manipulators. Furthermore, to find the most influential variables, a Mann Whitney test was carried out by using the SPSS. The result indicates that in 2020 and 2021, respectively, around 10% and 17% of registered companies are suspected of committing fraud. This study also reveals accounts in financial statements such as revenue, sales, profit, and cash flow to be very important key accounts that need to be considered in assessing financial statements because the information contained a significant possibility to be manipulated.
STRATEGI USAHA PEDAGANG KAKI LIMA (PKL) DI KOTA METRO: PASCA PANDEMI COVID-19
Authors: Nurhidayanti Ditta , Akbar Estelee Elora
Published: June 2023

The purpose of this study is to identify and analyze the sales strategies of street vendors (PKL) in Metro City: Post-covid-19 pandemic. This research was conducted on Jl. Ki Hajar Dewantara, East Metro sub-district, Metro City, Lampung Province. This type of research is descriptive qualitative research. The data source used is the primary data source. Collecting data in this study using observation, interviews and documentation. The results that can be concluded in this study are identifying trading strategies that must be implemented by street vendors who are affected by Covid 19. At the beginning of the pandemic, their income had decreased but over time they were able to get up and maintain their business. The strategy for street vendors on Jl. Ki Hajar Dewantara in maintaining his business in the midst of the Covid 19 pandemic, including by expanding market share by going online, creating new products and cooperating with other business actors.
ANALISIS RASIO KEUANGAN UNTUK MENILAI KINERJA KEUANGAN PERUSAHAAN DAERAH AIR MINUM KABUPATEN KUPANG
Authors: Hege Marselinda , Jagi Kretisana , Atto Aplonia , Susilawati Made , Selan Dwi Dersmi
Published: June 2023

The purpose of this study was to find out and analyze the Financial Performance of Regional Drinking Water Companies in Kupang Regency in terms of financial ratios (liquidity ratios, solvency ratios, activity ratios, profitability ratios) for 2018 – 2020. The data needed in this study are financial reports. The data collection techniques used are documentation and interviews. The data analysis technique used is financial ratio analysis based on the Decree of the Minister of Home Affairs Number 47 of 1999. Financial performance is assessed on a rating ratio scale of 1 (not good) to 5 (very good). The results of this study indicate that the Liquidity Ratio used, namely the current ratio, is included in the classification of very good. Depreciation expense on principal and interest installments is classified as very good. The activity ratio consists of the time period for collection of accounts receivable which is included in the poor classification, the ratio of earning assets to sales is included in the very good classification, the effectiveness ratio for collecting receivables is included in the very good classification. Finally, the Profitability Ratio from 2018 to 2020 has fluctuated. Overall, the financial performance of PDAM Kabupaten Kupang is classified as unfavorable. Implication: To improve financial performance, companies need to increase working capital which has an impact on operating profit. Furthermore, the Company can use productive assets to generate sales
PENGARUH KUALITAS PRODUK, HARGA, DAN LOKASI TERHADAP KEPUTUSAN PEMBELIAN MARTABAK ALONG 89 LAMPUNG
Authors: Wijaya Ricky , Habiburahman Habiburahman
Published: June 2023

This research intends to analyse the effect of the product quality, price, and location on purchasing decisions in an MSME. Researchers took samples namely Martabak Along 89 Lampung and using consumers from Martabak Along 89 Lampung as respondents for this research also researchers distributed questionnaires via google form. The sampling technique used was accidental sampling and there were 55 respondents in this research. The analytical method used is multiple linear regression analysis. The result of this research concludes that product quality, price, and location have a significant positive influence on purchasing decisions at Martabak Along 89 Lampung.
Analisis Efisiensi dengan Metode Data Envelopment Analysis (DEA) pada Lembaga Amil Zakat Muhammadiyah
Authors: Fuad Lian
Published: June 2023

One form of effort to improve the quality of institutional management is to measure the achievement of targets that have been planned. Achievement will be efficient if the input as institutional capital in running the institution makes a small contribution but gets the maximum output. The purpose of this research was to determine the efficiency level of the Amil Zakat Muhammadiyah Institute for the 2017-2020 period using the Data Envelopment Analysis (DEA) method with the Assumption of Constant Return of Scale (CRS) with input orientation. Research variabels use input and output. The input variabel component is operational costs. Personnel costs, outreach costs, and total assets. While the output variabel components are receipt of ZIS funds and distribution of ZIS funds. The results showed that in all periods from 2017-2020, efficiency performance was 100% or 1. But in 2019, Lazismu's efficiency performance earned a value of 0.977.
Pengaruh Lingkungan Kerja Fisik Terhadap Kepuasan Kerja Karyawan PD Sahang Mas
Authors: Andreas Farrel , Santati Parama , Farla Wita
Published: June 2023

To improve employee performance, every organization needs to pay attention to the job satisfaction of its employees. One of the factors that can affect employee job satisfaction is the environmental conditions in the place where he works, both physical and non-physical. This study aims to analyze the effect of the physical work environment on job satisfaction of PD Sahang Mas employees. The population in this study were all employees of PD Sahang Mas, totaling 33 employees. With saturated sampling technique, the number of samples used in this study amounted to 33 employees. The data collection method used was questionnaires using a 5-point Likert scale. The instrument test was carried out using validation and reliability tests. The analysis technique used is simple linear regression analysis using the SPSS application. Based on the results of the analysis it was concluded that the physical work environment has a positive and significant effect on the job satisfaction of PD Sahang Mas employees.
PENGARUH PERSEPSI HARGA DAN KUALITAS PELAYANAN TERHADAP KEPUTUSAN PEMBELIAN DI MINI MARKET CAHYA 99 DI DESA GONILAN KARTASURA
Authors: Hartanto Lius , Putra Ghanim Permana , Arinta Deva Novia , Enjarwati Aliffia Ori , Ramadhan Viona Rizky , Rahadhini Marjam Desma
Published: June 2023

The purpose of this study is to find out about the effect of perceived price and service quality on purchasing decisions. This research was conducted at the cahya 99 mini market in Gonilan Kartasura Village, by distributing questionnaires to 30 respondents. Samples were taken using random sampling technique. From the results of this study it is known that the regression equation is 10.288+0.462X1+0.083X2. From the results of statistical analysis data, the indicators in this study are said to be valid and reliable. The variable that has the most dominant influence is the price perception variable with a coefficient of 0.462. While the least influential variable is the service quality variable with a regression coefficient of 0.083. The price perception variable with a calculated T value of 3.620 with a significant value of 0.003 (0.003 <0.05) which means it has a significant value and for service quality obtains a T test result of 0.764 with a significant value of 0.05 (0.452 <0.05 ) which means it has a significant value. So it can be concluded that the perception of price and service quality has an effect on purchasing decisions at the cahya 99 mini market in Gonilan Kartasura Village. Perceptions of price and service quality are key strategic roles that are important to be considered in purchasing decisions at the Cahya 99 Minimarket in Gonilan Kartasura Village.
Biochemical characteristics and functional performance of cold-stored platelets: an in-vitro comparative study
Authors: Byomy Marwa , El Ekapy Magdy , Elmanzalawy Gamal , El Hakeem Amr , ElKharasawy Amr , Ibrahim Nehad R. , Ghani Amani , Abdellatif Raghda
Published: June 2023

Background: Platelet refrigeration could eliminate bacterial contamination and improve the hemostatic function even better than already-used room-temperature storage. This study aimed to assess the effect of cold storage, with and without agitation, on the apheresis platelets' hemostatic, metabolic, and functional activity. Materials and methods: The study included 10 healthy volunteer donors to collect Apheresis PLT. They were submitted to careful clinical examination and standard laboratory workup. Collected samples were processed in accordance with American Association of Blood Banks (AABB) guidelines. Every aliquot collected from each volunteer was stored for up to 5 days at one of the following storage conditions: 1. In an FDA-approved-PLT incubator with agitation at room temperature (RT + AG as a group; GI), 2. In an FDA-approved-refrigerator at 4 oC with agitation (4 oC + AG as a group; GII), 3. In an FDA-approved- refrigerator at 4 oC without agitation (4 oC – AG as a group; GIII). The following PLT workup was done; PLT count and mean platelet volume (MPV), metabolic variables, PLT aggregation studies, PLT receptors expression, and PLT pro-inflammatory mediator’s release.Results:All samples had a significant PLT count decline compared to baseline data. No changes in MPV were observed in all groups on day 3 and day 5, meaning that single PLT size remained unchanged. In addition, GI showed a mark of significant increase in metabolic activity when compared to baseline PLTs in contrast to GII, and GIII, which were more metabolically stable and less active.Comparison between the studied groups regarding PLT aggregation revealed significantly higher PLT aggregation response to ADP and collagen in GII and GIII compared to GI on the 3rd and 5th days. Moreover, it was shown that GII and GIII samples had significantly higher CD62p expression when compared with GI on the 3rd and 5th days despite being less active and more stable. While it was found that TXB2 levels were significantly higher, nearly 3-fold, in GI as compared to GII and GIII.Conclusions: Apheresis platelets (AP) cold storage provides a clear advantage over standard conditions regarding biochemical balance and hemostatic performance, which could markedly improve AP's clinical and economic value in different scenarios.  Keywords: Platelet aggregation, P-selectin, Thromboxane B2.
The Human Brain in Ancient Egypt
Authors: Sofia Aziz
Published: June 2023

The Human Brain in Ancient Egypt provides a medical and historical re-evaluation of the function and importance of the human brain in ancient Egypt. The study evaluates whether treatment of the brain during anthropogenic mummification was linked to medical concepts of the brain. The notion that excerebration was carried out to rid the body of the brain continues to dominate the literature, and the assumption that the functions of the brain were assigned to the heart and therefore the brain was not needed in the afterlife persists. To assess the validity of these claims the study combines three investigations: a radiological survey of 33 subjects using the IMPACT mummy database to determine treatment of the cranium; an examination of the medical papyri for references to the human brain; and an inspection of the palaeopathological records to look for evidence of cranial injuries and ensuing medical treatments.

The results refute long held claims regarding the importance of the human brain in ancient Egypt. Many accepted facets of mummification can no longer hold up to scrutiny. Mummification served a religious ideology in which the deceased was transformed and preserved for eternity. Treatment of the brain was not determined to be significantly different from the visceral organs, and the notion that the brain was extracted because it served no purpose in the afterlife was found to be unsubstantiated.
Roman Funerary Rituals in Mutina (Modena, Italy)
Authors: Riso Federica Maria
Published: June 2023

This study presents the results of a research project undertaken in collaboration with the University of Huddersfield. The project sought to identify and reconstruct the funerary space and rituals of the necropolis in Mutina (now Modena) in the period between the first century BC and second century AD. The research is a key example of integrated analyses, linking the different results in the same interpretative system and supporting traditional strategies (archaeology and archaeobotany) with advanced technology (SAXS, CT-scan). The archaeobotanical remains (seeds and fruit) and the objects involved in the ceremonies constitute an important investigatory lens to reconstruct the mortuary rituals and attendance at the funerary space.
Les représentations de Mars Ultor sur les pierres gravées
Authors: Thibault Girard
Published: June 2023

Les représentations de Mars Ultor sur les pierres gravées is principally devoted to engraved stones representing the Mars Ultor type and aims to restore them to their rightful place. When Adolf Furtwängler, in his study of the Somzée collection, determined the Mars Ultor type from a statuette in the same collection, he chose to use only two artefacts for comparison: the engraved gem from the Marlborough collection and a sesterce of Antoninus Pius. Monumental sculpture and reliefs did not provide reliable anchors for the type. Even the famous statue from the Capitoline Museum did not find favour with him. Paradoxically, the studies that followed Furtwängler''s focused on the ‘high arts’, intentionally leaving aside the intaglios and the glass pastes, which are the only contemporary examples of the original statue, now lost.

Gems representing the Mars Ultor type were produced between the 1st and 4th centuries. They attest to the longevity and impact of the Augustan image in Roman iconography and allow us to follow the variations in meaning of the motif. Scattered around the world and without documented contexts, the 240-odd engraved stones gathered here prove – if it were still necessary to do so – that the great masterpieces of art history have had a much more important survival on these small objects than on the great monuments traditionally at the centre of iconographic studies. Comparison with statuettes and coins representing the Mars Ultor type also offers a historical and religious view of the cult of the god, promoted by Octavian after the Battle of Philippi.
Evaluation of abdominal vascular structures by multidetector computed tomography in Crimean–Congo hemorrhagic fever patients
Authors: ÖZMEN Zafer
Published: June 2023

Aim: This study aims to determine whether Crimean–Congo Hemorrhagic Fever (CCHF) has effects on abdominal vascular structures.

Material and Method: The study group included 35 patients diagnosed with CCHF. The control group included 35 patients with symptoms such as dyspepsia, pelvic pain, and abdominal pain who underwent multidetector computed tomography (MDCT) and whose MDCT examinations were reported as completely normal. This is a retrospective study and patients admitted to the hospital between May 2016 and April 2022 were included in the study. The patient group and control group were compared in terms of liver size, splenic size, and portal vein (PV), hepatic artery (HA), splenic vein (SV), splenic artery (SA), superior mesenteric vein (SMV) and superior mesenteric artery (SMA) diameters.

Results: The liver size, splenic size, and PV, HA, and SA diameters in the patient group were significantly higher than those in the control group (p0.05).

Conclusion: Our study shows that abdominal vascular structures are affected in CCHF patients.
The relationship between thoracic CT findings and C-reactive protein and ferritin levels in COVID-19 patients
Authors: SAĞLIK Semih , NAS Necip , ALTUNIŞIK Bilal
Published: June 2023

Aim: In this study, we aimed to establish the relationship between thoracic computed tomography (CT) findings at initial presentation and CRP and ferritin levels in 232 patients diagnosed with COVID-19.

Material and Method: 232 patients who were diagnosed with COVID-19 and underwent a thoracic CT examination at our hospital between Apr 2020 and Aug 2021 were enrolled in this study. The study group was selected from among individuals aged 18-45 years without any chronic diseases and comorbidities. The patients' complaints, RT-PCR test results and blood biochemistry values from the medical records system, and CT imaging from the PACS system were reviewed retrospectively. Parenchymal lesions, ground-glass area, consolidation and combination of ground-glass area and consolidation observed on thoracic CT were considered typical findings. Blood samples were analyzed in the laboratory using standard methods. Routine blood tests were performed to measure serum C-reactive protein and ferritin levels.

Results: Out of the 232 patients infected with COVID-19, 118 were female and 114 were male. While the mean age of all patients was 34.9, the mean ages of men and women were 34.9 and 35.2, respectively. No significant differences were observed between the ages of patients with and without lung involvement (32.9, 37.9, p=0.903, respectively). CT scan showed typical parenchymal findings in 140 patients out of whom 65 were male and 75 were female. With regard to the morphologic features observed on CT, ground-glass density was the most common (74 patients), followed by a combination of ground-glass density and consolidation (34 patients) and finally consolidation (32 patients). In statistical analysis, no significant differences were found in CRP values between patients with and without lung involvement, whereas a significant difference was noted in ferritin values (p=0.196 and p
Evaluation of MULBSTA, SOFA, APACHE II scores and hematological parameters as predictors of mortality in COVID-19 pneumonia
Authors: GÜLSOY Kemal Yetiş , ANCIN Burcu , ORHAN Semiha
Published: June 2023

Aim:  COVID-19 (coronavirus disease 2019) pneumonia is a serious condition with high mortality and morbidity. Tools are needed for effective diagnosis and better prediction of prognosis in the course of this disease. This study aimed to compare the effectiveness of the MuLBSTA (Multilobular infiltration, hypo-Lymphocytosis, Bacterial coinfection, Smoking history, hyper-Tension and Age) score with blood parameters, SOFA (Sequential Organ Failure Assessment), and APACHE II (Acute Physiology and Chronic Health Evaluation II) scores, and to investigate its significance in predicting 28-day mortality in patients diagnosed with COVID-19 and followed up in the intensive care unit (ICU).

Material and Method: This study included 312 patients admitted to ICU for COVID-19 infection. SOFA, MuLBSTA and APACHE-II scores of patients were estimated at ICU admission. Demographic data and laboratory results of patients were retrospectively reviewed.

Results: Of the 312 patients included in the study, 58.7% (n=183) were male and 41.3% (n=129) were female. The AUC value was 0.863 for the SOFA score and 0.843 for the MuLBSTA score. The MuLBSTA score was positively correlated with the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), while it was negatively correlated with the lymphocyte-to-monocyte ratio (LMR). Patients were divided into two groups as high-risk and low-risk, considering a cut-off value of 12 for the MuLBTSA score. The survival time of patients with a high-risk MuLBTSA score was 12±0.78 days, while the survival time of patients with a low MuLBTSA score was 22.8±1.3 days.

Conclusion: The combined use of the MuLSBTA score, SOFA score, and NLR after ICU admission for COVID-19 pneumonia will be more effective in predicting mortality.
Outcomes of multiple pregnancies: results of a perinatology clinic in a tertiary health center
Authors: SEVER Barış , EKİN Atalay
Published: June 2023

Aim: To evaluate maternal-fetal risks and pregnancy outcomes in multiple pregnancies.

Material and Method: The study included 226 patients with multiple pregnancies who applied to the Perinatology clinic of Izmir Tepecik Training and Research Hospital between January/2020 and December/2022. The data of the patients were recorded and evaluated retrospectively using the hospital database.

Results: Of 226 patients, 211 were twins, 14 were triplets and one was quadruplet. Pregnancy occurred after in vitro fertilization (IVF) in 116 patients and after donation in 1 patient. 55.7% of the patients were older than 35 years. While 137 pregnants (60.6%) were primiparous, 89 patients (39.3%) had a previous pregnancy. While 20 of the twin pregnancies delivered before the 25th gestational week, this number was found to be 7 for triplets. 202 (89.3%) of all multiple pregnant women were delivered by cesarean section. Hypertensive disorder was found in 28 of the twin pregnancies and in 4 of the triplet pregnancies. Gestational diabetes was observed in 41 twin and 3 triplet pregnancies. Small for gestational age (SGA) was observed in 121 twins, 13 triplets and 1 quadruplet pregnancy. Intrauterine growth retardation (IUGR) was observed in 76 twins and 6 triplets. The number of multiple pregnancies with a birth weight less than 2500 g was found to 187 (82.7%) in total. Major congenital anomalies of various organs (cardiac, central nervous system, etc.) were observed in 8 (3.5%) pregnant women.

Conclusion: Preterm birth, increased maternal morbidity and increased cesarean section frequency are some of the risks of multiple pregnancies. These risks can be reduced by knowing the potential risks of multiple pregnancies and by more careful follow-up starting from the early stages of pregnancy.
Comparison of risk scoring systems for the prediction of clinical outcomes in nonvariceal upper gastrointestinal bleeding: a prospective randomized study
Authors: DURAK Muhammed Bahaddin , BAŞPINAR Batuhan , GÜVEN İbrahim Ethem , YÜKSEL İlhami
Published: June 2023

Aim: Non-variceal upper gastrointestinal bleeding (UGIB) is a typical gastrointestinal emergency. Detection of high-risk patients is crucial to organize medical care accordingly. This study aims to compare risk assessment scores for their ability to predict prognosis in nonvariceal-UGIB.

Material and Method: Adult patients with nonvariceal-UGIB applied to the emergency department were recruited prospectively. Clinical and Complete Rockall score (RS), Glascow-Blatchford score (GBS), AIMS65, and T-Score were compared for endpoints: (1) need for endoscopic treatment, (2) hospitalization, (3) rebleeding, and (4) 30-day mortality.

Results: A total of 469 patients were included. While 133 (28.0%) patients were discharged within 24 hours, 336 (72.0%) were hospitalized. The median length of hospital stay was 6.6 (0.0-8.0) days. Endoscopic treatment and transfusion were required in 109 (23.0%) and 255 (54.0%) patients, respectively. Rebleeding was observed in 36 (8.0%) patients. The 30-day mortality rate was 11.0 %. Complete Rockall score was superior among all risk scores regarding the prediction of the need for endoscopic treatment (AUC: 0.707, p
Confirmed Synergy Between the ɛ4 Allele of Apolipoprotein E and the Variant K of Butyrylcholinesterase as a Risk Factor for Alzheimer’s Disease: A Systematic Review and Meta-Analysis
Authors: Ratis Renan C. , Dacoregio Maria I. , Simão-Silva Daiane P. , Mateus Rogério P. , Machado Luciana P.B. , Bonini Juliana S. , Silva Weber Claudio Francisco Nunes da
Published: June 2023

Background:

Alzheimer’s disease (AD) has several risk factors. APOE4 is the main one, and it has been suggested that there may be a synergy between it and BCHE-K as a risk factor.

Objective:

To investigate the association between APOE4 and BCHE-K as a risk factor for AD.

Methods:

We searched PubMed, Web of Science, Embase, and Scopus on August 8, 2021 for studies that analyzed the association of APOE4 and BCHE-K with AD. The random effect model was performed in meta-analysis according to age group. A chi-square was performed with the meta-analysis data to verify if the effect found is not associated only with the E4 allele.

Results:

Twenty-one studies with 6,853 subjects (3,528 AD and 3,325 Controls) were included in the meta-analysis. The quality of the evidence is moderate. There is a positive E4-K association for subjects with AD as shown by the odds ratio of 3.43. The chi-square meta test, which measures the probability that the E4-K association is due to chance, has an odds ratio of 6.155, indicating that the E4-K association is not a random event. The odds ratio of an E4-K association in subjects with AD increases to OR 4.46 for the 65- to 75-year-old group and OR 4.15 for subjects older than 75 years. The probability that the E4-K association is due to chance is ruled out by chi-square meta test values of OR 8.638 and OR 9.558.

Conclusion:

The synergy between APOE4 and BCHE-K is a risk factor for late-onset AD.
Interest rate derivatives for the fractional Cox-Ingersoll-Ross model
Authors: Bishwal Jaya P.N.
Published: June 2023

We obtain the bond price formula for the fractional Cox-Ingersoll-Ross model. Then we obtain option price formula for the bond. Finally we apply it to derive option price formula in fractional Heston model.
Cell-free circulating ALU repeats in serum have a prognostic value for colorectal cancer patients
Authors: Anzinger Isabel , Nagel Dorothea , De Toni Enrico N. , Ofner Andrea , Philipp Alexander B. , Holdt Lesca M. , Teupser Daniel , Kolligs Frank T. , Herbst Andreas
Published: June 2023

BACKGROUND: Carcinoembryonic antigen (CEA) is the only established serum biomarker for colorectal cancer (CRC). To facilitate therapy decisions and improve the overall survival of CRC patients, prognostic biomarkers are required. OBJECTIVE: We studied the prognostic value of five different cell free circulating DNA (fcDNA) fragments. The potential markers were ALU115, ALU247, LINE1-79, LINE1-300 and ND1-mt. METHODS: The copy numbers of the DNA fragments were measured in the peripheral blood serum of 268 CRC patients using qPCR, the results were compared to common and previously described markers. RESULTS: We found that ALU115 and ALU247 fcDNA levels correlate significantly with several clinicopathological parameters. An increased amount of ALU115 and ALU247 fcDNA fragments coincides with methylation of HPP1 (P< 0.001; P< 0.01), which proved to be a prognostic marker itself in former studies and also with increased CEA level (both P< 0.001). ALU115 and ALU247 can define patients with poor survival in UICC stage IV (ALU115: HR = 2.9; 95% Cl 1.8–4.8, P< 0.001; ALU247: HR = 2.2; 95% Cl 1.3–3.6; P= 0.001). Combining ALU115 and HPP1, the prognostic value in UICC stage IV is highly significant (P< 0.001). CONCLUSIONS: This study shows that an increased level of ALU fcDNA is an independent prognostic biomarker for advanced colorectal cancer disease.
Construction of a prognostic signature of RFC5 immune-related genes in patients with cervical cancer
Authors: Chen Huaqiu , Xie Huanyu , Zhang Yuanyuan , Wang Guangming
Published: June 2023

BACKGROUND: Cervical cancer (CC) is a malignant tumor threatening women’s health. Replication factor C (RFC) 5 is significantly highly expressed in CC tissues, and the immune microenvironment plays a crucial role in tumor initiation, progression, and metastasis. OBJECTIVE: To determine the prognostic role of RFC5 in CC, analyze the immune genes significantly associated with RFC5, and establish a nomogram to evaluate the prognosis of patients with CC. METHODS: High RFC5 expression in patients with CC was analyzed and verified through TCGA GEO, TIMER2.0, and HPA databases. A risk score model was constructed using RFC5-related immune genes identified using R packages. Combining the risk score model and clinical information of patients with CC, a nomogram was constructed to evaluate the prognosis of patients with CC. RESULTS: Comprehensive analysis showed that the risk score was a prognostic factor for CC. The nomogram could predict the 3-year overall survival of patients with CC. CONCLUSIONS: RFC5 was validated as a biomarker for CC. The RFC5 related immune genes were used to establish a new prognostic model of CC.
Hsa-miR-301a-3p inhibited the killing effect of natural killer cells on non-small cell lung cancer cells by regulating RUNX3
Authors: Zhang Junkai , Yang Yingyu , Wei Ying , Li Lamei , Wang Xinyi , Ye Zhihua
Published: June 2023

BACKGROUND: Non-small cell lung cancer (NSCLC) is the most commonly diagnosed solid tumor. Natural killer (NK) cell-based immunotherapy is a promising anti-tumor strategy in various cancers including NSCLC. OBJECTIVE: We aimed to investigate the specific mechanisms that regulate the killing effect of NK cells to NSCLC cells. METHODS: Reverse transcription-quantitative PCR (RT-qPCR) assay was applied to measure the levels of hsa-microRNA (miR)-301a-3p and Runt-related transcription factor 3 (RUNX3). Enzyme-linked immunosorbent assay (ELISA) was used to measure the levels of IFN-γ and TNF-α. Lactate dehydrogenase assay was applied to detect the killing effect of NK cells. Dualluciferase reporter assay and RNA immunoprecipitation (RIP) assay were carried out to confirm the regulatory relationship between hsa-miR-301a-3p and RUNX3. RESULTS: A low expression of hsa-miR-301a-3p was observed in NK cells stimulated by IL-2. The levels of IFN-γ and TNF-α were increased in NK cells of the IL-2 group. Overexpression of hsa-miR-301a-3p reduced the levels of IFN-γ and TNF-α as well as the killing effect of NK cells. Furthermore, RUNX3 was identified to be a target of hsamiR-301a-3p. hsa-miR-301a-3p suppressed the cytotoxicity of NK cells to NSCLC cells by inhibiting the expression of RUNX3. We found hsa-miR-301a-3p promoted tumor growth by suppressing the killing effect of NK cells against NSCLC cells in vivo. CONCLUSIONS: Hsa-miR-301a-3p suppressed the killing effect of NK cells on NSCLC cells by targeting RUNX3, which may provide promising strategies for NK cell-based antitumor therapies.
Environmentally Sound Technologies for Climate Change Mitigation in BRICS Countries: A Comparative Policy and Legal Perspective
Authors: Tripathi Mahima , Bhattacharya Niharika Sahoo
Published: June 2023

The adoption of environmentally sound technologies (ESTs), with potential for significantly improving environmental performance relative to other technologies, provide one of the effective steps for achieving the Sustainable Development Goals (SDGs). The grouping of emerging economies of Brazil, Russia, India, China and South Africa (BRICS) significantly contributes to greenhouse gas (GHG) emissions and climate change. Hence the BRICS countries have a great potential in mitigating GHG emissions. They can play a key role in the global climate change negotiations. Therefore, adoption of ESTs in these countries play a crucial role in mitigating climate change. In this context, this paper analyses the national laws and plans in BRICS countries pertinent to ESTs that can contribute in attaining the “stabilization of GHG concentrations in the atmosphere” (Article 2) objective of the United Nations Framework Convention on Climate Change (UNFCCC). The legal provisions for development, dissemination, and technology transfer commitments concerning ESTs in general and within the BRICS countries in particular are analyzed to understand the current position and future directions toward climate change mitigation.
The Association Between Neutrophil-Lymphocyte Ratio and Variability with New-Onset Dementia: A Population-Based Cohort Study
Authors: Chou Oscar Hou In , Zhou Jiandong , Li Lifang , Chan Jeffrey Shi Kai , Satti Danish Iltaf , Chou Vanessa Hou Cheng , Wong Wing Tak , Lee Sharen , Cheung Bernard Man Yung , Tse Gary , Chang Carlin , Liu Tong
Published: June 2023

Background: Previous studies identified that neutrophil-to-lymphocyte ratio (NLR) may be a predictor of dementia. However, the associations between NLR and dementia at the population level were less explored. Objective: This retrospective population-based cohort study was designed to identify the associations between NLR and dementia among patients visiting for family medicine consultation in Hong Kong. Methods: The patients were recruited from January 1, 2000, to December 31, 2003, and followed up until December 31, 2019. The demographics, prior comorbidities, medications, and laboratory results were collected. The primary outcomes were Alzheimer’s disease and related dementia and non-Alzheimer’s dementia. Cox regression and restricted cubic spline were applied to identify associations between NLR and dementia. Results: A cohort of 9,760 patients (male: 41.08% ; baseline age median: 70.2; median follow-up duration: 4756.5 days) with complete NLR were included. Multivariable Cox regression identified that patients with NLR >5.44 had higher risks of developing Alzheimer’s disease and related dementia (hazard ratio [HR]: 1.50, 95% Confidence interval [CI]: 1.17–1.93) but not non-Alzheimer’s dementia (HR: 1.33; 95% CI: 0.60–2.95). The restricted cubic splines demonstrated that higher NLR was associated with Alzheimer’s disease and related dementia. The relationship between the NLR variability and dementia was also explored; of all the NLR variability measures, only the coefficient of variation was predictive of non-Alzheimer’s dementia (HR: 4.93; 95% CI: 1.03–23.61). Conclusion: In this population-based cohort, the baseline NLR predicts the risks of developing dementia. Utilizing the baseline NLR during family medicine consultation may help predict the risks of dementia.
Micro- and Macronutrient Intake and Food Group Frequency Consumed by Subjects with Cognitive Impairment and Dementia in Latin America: A Systematic Review
Authors: Garrido-Dzib Angel Gabriel , Chávez-Loría Geovanni , Magallón-Zertuche Valeria , Avila-Nava Azalia , Palacios-González Berenice , Gutiérrez-Solis Ana Ligia
Published: June 2023

Background: Nutrition has relevant role in the pathogenesis of dementia. However, in Latin American Countries (LAC), it is unknown which type of diet the subjects with dementia and cognitive dysfunction have. Objective: The main purpose of this study was to determine micro- and macronutrients and food frequency intake among the LAC population with mild cognitive impairment (MCI) and dementia. Methods: A systematic review using PubMed, Cochrane, Lilacs, and Scielo databases. Energy intake as well as micro- and macronutrients intake were analyzed using a random-effect model and presented in a forest plot. Results: Nine articles were included, an estimated energy intake of 1598.47 kcal (95% CI 1351.07–1845.88) was obtained. A daily consumption of 73.64 g/day (95% CI 64.07–83.2) of protein; 262.17 g/day (95% CI 214.51–309.93) of carbohydrates, and 57.91 g/day (95% CI 49.16–66.66) of fats were reported. A micronutrients daily intake consumption of 201.35μg/day of vitamin B9 (95% CI 125.32–277.38); 5.61μg/day of vitamin B12 (95% CI 2.53–8.70), and 139.67 mg/day of vitamin C (95% CI 59.33–220.02). Mineral intake of 637.32 mg/day of calcium (95% CI 288.54–986.11) and 9 mg/day of iron (95% CI 2.28–15.71) was obtained. A low intake of fruits and vegetables was found. Conclusion: Individuals with MCI and dementia from LAC have a nutritional deficiency characterized by a lower intake of fruits and vegetables, a high consumption of carbohydrates and protein, adequate fats intake and vitamins B12, vitamin C, and iron consumption, but a low intake of vitamin B9 and calcium.
Young Adult Brain Capital: A New Opportunity for Dementia Prevention
Authors: Farina Francesca R. , Booi Laura , Occhipinti Jo-An , Quoidbach Vinciane , Destrebecq Frédéric , Muniz-Terrera Graciela , Eyre Harris A.
Published: June 2023

The potential for future prevention of Alzheimer’s disease and related dementias (ADRD) through healthy lifestyle change is spurring a positive brain health movement. However, most ADRD research continues to focus on mid- and later life. We lack evidence regarding risk exposure and protective factors in young adulthood, i.e., 18–39 years. Brain capital is an emerging framework that represents the combination of education, knowledge, skills, and optimal brain health that people accumulate over their lives. Building on this framework, we present a new model that focuses on optimizing brain health in young adulthood; namely, young adult brain capital. Increasing focus on younger populations is critical for developing citizens who are emotionally intelligent, resilient and can anticipate and cope with rapid changes in the world. By understanding the values that are key drivers and motivators for young adults, we can empower the next generation to become active agents in optimizing their brain health and reducing their risk for future ADRD.
Fuzzy assessment and improvement path of green finance quality in “Belt and Road”: Survey evidence from China
Authors: Liu Yu
Published: June 2023

The “One Belt and One Road” is a major strategic deployment proposed by Chinese President Xi Jinping in 2013, and it is important to study the construction of green financial system under the “One Belt and One Road” initiative, especially the quality assessment of green finance to promote high-quality economic development along the route. At the same time, green finance and green “Belt and Road” have become a hot academic topic in the world. In this study, firstly, on the basis of the existing research on green finance, focusing on the evaluation of economic quality of green finance, we innovatively draw on the quality function deployment theory in marketing to logically transform our research ideas and propose a combined comprehensive evaluation method based on the hierarchical analysis (AHP) and entropy method in fuzzy mathematical theory, which makes up for the traditional single fuzzy evaluation method’s influence on the evaluation results. This method makes up for the shortcomings of the traditional single fuzzy evaluation method to evaluate the results of subjective or objective weighting results. In this study, we apply this method to the assessment of the quality of green finance development in “One Belt, One Road”, and it is important that we construct a system of “One Belt, One Road” green finance quality assessment indicators, including one primary indicator, four secondary indicators and 12 tertiary indicators. It is worth noting that our indicator system is different from the traditional quality system of financial quality assessment in that we take green factors into account in the construction of the tertiary indicators, and then use this assessment method to calculate and rank the weights (importance) of the 12 tertiary indicators, taking the actual situation in China as an example. More importantly, our study not only extends the academic research results of economic quality evaluation, but also combines quantitative research with qualitative analysis to propose three targeted countermeasures for the development of green finance in the countries along the Belt and Road. This study can also provide theoretical support for the quality assessment of green finance in countries along the Belt and Road, and promote the high-quality development of green finance in countries along the Belt and Road.