bluuebunny/crossref_metadata_2025 huggingface dataset:
Modern comprehensive information system for environmental quality monitoring
Authors:   Kyiv National University of Construction and Architecture, Honcharenko Artem , Voloshkina Olena ,   Kyiv National University of Construction and Architecture, Kupinskyi Ihor ,   Kyiv National University of Construction and Architecture, Zhukova Olena ,   Kyiv National University of Construction and Architecture
Published: November 2021

The threat to ecological balance can turn into a global problem, and we observe its deviations, which arise as a result of complex relationships between natural and social environments. Direct and indirect human impact on Earth's ecosystems together and interdependently form the planet's ecosystem, resulting in changes in the social environment of a human. Today's global problems are increasingly shifting to the side of developing countries, where environmental pressure is increasing because along with "pre-industrial" pollution, a new one is emerging, related to the invasion of multinational corporations and "exports" of polluting industries to "third world" countries. Modern "industrial" pollution in developing countries is the result of the transfer of many polluting industries to the "third world", such as the construction of enterprises, chemical plants, chemicalization of agriculture. Due to this, the concentration of the population in the largest agglomerations is growing.
Prospects of cleaning filtrates by aerobic-reagent method on the example of Lviv region
Authors:   Lviv Polytechnic National University, Malovanyу Myroslav , Zhuk Volodymyr ,   Lviv Polytechnic National University, Tymchuk Ivan ,   Lviv Polytechnic National University, Vronska Nataliya ,   Lviv Polytechnic National University, Zavoyko Bogdan ,   Lviv Polytechnic National University, Senkovych Olha ,   Lviv Polytechnic National University
Published: November 2021

In 2021, the situation with the collecting, processing and disposal of waste in general, solid waste in particular, remains difficult in Ukraine and needs to be solved immediately. Soil contamination, as well as contamination of surface and ground waters by filtration effluents (or filtrates), is one of the most dangerous consequences of non-regulatory disposal of solid household waste.
DINAMIKA DAN HAMBATAN DALAM PEMBERDAYAAN MASYARAKAT PESISIR DI PLABUHAN RATU KABUPATEN SUKABUMI
Authors:   FISIP Universitas Lampung, Amriwan Azis
Published: November 2021

Penelitian ini bertujuan untuk menjelaskan dinamika yang terjadi dalam pelaksanaan program pemberdayaan masyarakat pesisir. Penelitian ini juga ingin melihat proses reproduksi praktik dominasi dalam masyarakat pesisir yang menjadi faktor penghambat dalam pemberdayaan nelayan. Penelitian ini menggunakan pendekatan kualitatif dengan metode deskriptif untuk menggali relasi sosial dalam masyarakat pesisir yang melibatkan nelayan, juragan (taweu), kelompok nelayan dan pemerintah dalam perspektif strukturasi Giddens. Hasil penelitian menunjukkan bahwa program pemberdayaan masyarakat pesisir di Palabuhanratu Kabupaten Sukabumi bersifat charity berupa Bantuan Langsung Masyarakat (BLM) dan bersifat stimulus seperti program Pengembangan Usaha Mina Perdesaan (PUMP) Perikanan Tangkap. Konsep pemberdayaan semacam ini hanya bersifat sementara, parsial dan belum menyentuh persoalan utama dalam struktur sosial masyarakat pesisir yang bersifat patron-klien. Nelayan merupakan kelompok masyarakat pesisir yang paling sulit untuk keluar dari jaring kemiskinan. Kebijakan pemerintah dalam pembangunan sektor kelautan dan perikanan, mekanisme pasar, dan dominasi kelompok nelayan (KUB) oleh juragan (taweu), menyebabkan nelayan mengalami ketergantungan terhadap akses (jaringan, modal dan pengetahuan) sebagai bentuk dominasi struktural. Temuan penelitian menunjukkan bagaimana nelayan dapat keluar dari jerat kemiskinan ataupun dominasi struktural ketika nelayan menggunakan faktor keagenannya. Praktik sosial yang dialami secara berulang membentuk kesadaran nelayan, yakni memanfaatkan akses yang dimiliki. Dalam konteks program pemberdayaan, nelayan dapat bersikap pragmatis ataupun otonom.
Obtaining and characterizing biodegradable composites from agroenergetic residues
Authors: Figueiredo Hélida Cristina Noronha , Serra Juan Carlos Valdés , Souza Marcus Vinicius Ribeiro e
Published: November 2021

The study aimed to produce biodegradable composite materials from sugar cane straw and castor oil-based resin. The fibers were used in two sizes: 0 <fibers ≤4.27mm and 4.27 <fibers <10mm; resin in the proportion of 10%, 15% and 20%. The preparation method was carried out according to NBR 14810-2: 2018, using the compression molding technique at room temperature. Physical assays were carried out: moisture and swelling; mechanical assays: static bending and compression. The morphological assay was evaluated: scanning electron microscopy; and the composite biodegradability assay, over a three-month period. In order to validate the results, the statistic graphic was performed with significance at 5% by the F test, compared to the means by the Scott-knott test of the physical and mechanical treatments. The results showed that the values of the physical assays have met the minimum limits established by the standard, resulting in 8.72% swelling of the composite material. In the mechanical assay, the composite with less fiber and 20% resin was more resistant in the bend test with a capacity of 3.69 N/mm², and in the compression assay with 2.98 N/mm². The morphological analysis showed a wide interaction at the matrix/reinforcement interface. The biodegradation assay showed that over the months the composites started to lose weight, which shows the improvement of the degradation. Therefore, the composite produced has great potential in the market, it is considered biodegradable and of low cost compared to composites produced from synthetic fibers.
The Development of E-Instrument to Test Students Mental Models on Electrolyte and Non-Electrolyte Solutions
Authors: Widayanti Yulia
Published: November 2021

The purpose of this study is to design an instrument that can be used to determine students mental models in electrolyte and non-electrolyte solutions. Students do not have complete understanding of electrolyte and non-electrolyte solutions topic. It takes an instrument that can measure students mental models, which can then be used to find out why students do not have complete understanding of electrolyte and non-electrolyte solutions topic. The research method used is the RnD method with a 4D model. The research steps consist of define, design and development. The results of this study are e-instruments that can be used to measure students mental models on electrolyte and non-electrolyte solutions. The average results of the instrument feasibility from material experts and teacher experts were 89 percent and 83 percent, namely worthy with very good predicate and good predicate. These results indicate that the designed instrument is feasible to use. The instrument designed only reached the validation stage due to lack of time in research.
Pengaruh Media Kartu Kuartet Terhadap Penguasaan Hiragana Siswa Kelas X SMAN 6 Padang
Authors: Marta Afriyona , Yulia Nova
Published: November 2021

AbstrakProses pembelajaran Bahasa Jepang di Indonesia masih sering menemui beberapa kendala dalam mempelajari huruf. Penggunaan huruf yang berbeda menjadi salah satu faktor yang menyebabkan pembelajar merasa kesulitan dalam mempelajari Bahasa Jepang. Karena ada prinsip yang tidak terpenuhi yaitu penggunaan media serta metode atau teknik yang digunakan tidak sesuai. Berdasarkan apa yang peneliti amati pada saat melaksanakan praktik lapangan kependidikan (PLK) di SMAN 6 Padang serta wawancara yang peneliti lakukan dengan siswa, menunjukkan minimnya minat dan kemampuan siswa dalam mempelajari hiragana. Sehingga pencapaian tujuan belajar tidak maksimal. Oleh karena itu, diperlukan media tertentu untuk mempermudah dalam menguasai dan sebagai pemacu untuk menarik minat siswa dalam mempelajari hiragana. Penggunaan media kartu kuartet dirasa dapat mengatasi permasalahan diatas. Tujuan dalam penelitian ini adalah untuk mengetahui bagaimanakah pengaruh dari media kartu kuartet terhadap penguasaan hiragana siswa kelas X SMAN 6 Padang. Penelitian ini menggunakan penelitian eksperimen semu, dengan posttes tonly control group design. Sedangkan teknik penyampelan menggunakan teknik purposive sampling. Sampel dalam penelitian ini adalah siswa kelas X MIPA 1 dan X MIPA 5 dengan jumlah 69orang. Hasil analisis data, diperoleh thitung dengan ttabel taraf signifikan 0,05% adalah 2,00 dengan derajat kebebasan dk=n1+n2-2. Hal ini berarti thitung  > ttabel  (3,41 > 2,00). Maka hipotesis diterima, karena thitung  > ttabel. Kata kunci: Hiragana, Media, Kartu Kuartet.
Analisis Kalimat Pasif Bahasa Jepang dalam Novel Kasei no Kioku Karya Raymond Jones
Authors: Putri Dita , Putri Meira Anggia
Published: November 2021

Penelitian ini dilatar belakangi oleh banyaknya penggunaan kalimat pasif dalam kehidupan sehari-hari. Selain itu juga banyak ditemukan pada film, drama, anime, buku pelajaran, novel, komik, dan lain sebagainya. Data Penelitian ini adalah kalimat pasif yang terdapat dalam novel Kasei no Kioku Karya Raymond Jones. Penelitian ini bertujuan untuk mengklasifikasikan dan mendeskripsikan jenis-jenis kalimat pasif bahasa Jepang yang terdapat pada novel Kasei no Kioku. Metode yang akan digunakan dalam penelitian ini adalah metode analisis deskriptif, yaitu dengan menjelaskan dan menganalisis kalimat-kalimat pasif yang terdapat dalam novel tersebut. Dari hasil penelitian, penulis menyimpulkan bahwa kalimat pasif yang lebih banyak digunakan dalam novel Kasei no Kioku adalah chokusetsu ukemi dengan jumlah 15 data dari 20 data kalimat pasif yang ditemukan. Data yang paling sedikit ditemukan adalah data daisansha no ukemi yang berjumlah 2 kalimat saja. Sedangkan data mochinushi no ukemi yang ditemukan berjumlah 3 kalimat.
Analisis Gaya Bahasa Metafora Pada Lirik Lagu Karya LiSA
Authors: Putri Annisa , Putri Meira Anggia
Published: November 2021

Song is a literary work that is enjoyed by all people, from young people to adults. In the song lyrics, there are many language styles, especially metaphorical styles. Metaphorical language style is an implicit comparative language style. One of the functions of using metaphors in writing song lyrics is to add beauty to the lyrics. Japanese songs are one of the most popular songs by Japanese students or learners, anime enthusiasts and the general public. LiSA is one of the popular Japanese singers whose songs are widely enjoyed. In this study, researchers analyzed the metaphorical language style of LiSA's song lyrics. This study aims to determine the types and meanings of metaphors in LiSA's song lyrics. This type of research is qualitative research with descriptive methods. The data in this study are in the form of phrases containing metaphors in the lyrics of LiSA's songs. The source of the data taken is the lyrics of a song by LiSA which is an anime soundtrack consisting of 8 songs including Adamas, Catch the Moment, Datte Atashi no Hero, Gurenge, Rally Go Round, Rising Hope, Shirushi, and Unlasting. This study uses the theory of Stephen Ullmann. Based on the results of the study, there were 4 types of metaphors, namely anthropomorphic metaphors with 9 data, synesthetic metaphors with 9 data, abstract metaphors with 22 data, and animal metaphors with 2 data. Besides that, there are different meanings in each metaphorical expression.
Projektmanagement-Effekte bei DB Cargo
Authors: Drachenberg Christian
Published: November 2021

Die steigende Anzahl der IT-Systeme der DB Cargo AG [1] – der Schienengüterverkehrstochter der Deutschen Bahn AG [2] – und die zunehmende Komplexität der Vernetzung dieser Systeme führte die traditionelle Arbeitsweise in Projekten der DB Cargo an ihre Grenzen. Eine im IT-Bereich beginnende Neustrukturierung der Projekte, der zugehörigen Prozesse und Verantwortlichkeiten, eröffnete der DB Cargo neue Wege und Möglichkeiten zur Weiterentwicklung, die vorher nicht im Fokus standen, aber zunehmend als „Best Practice“ empfunden werden. Nachdem IT-Projekte als „Vorreiter“ agierten und andere Bereiche in Folge die neuen Abläufe übernahmen, steigerte sich die Qualität der Projekte bei der DB Cargo weiter. In Zukunft wird es interessant zu beobachten und mitzuerleben, wie sich die Arbeits- und Projektkultur durch die Konzernstrategie „Starke Schiene“ [3] weiter verändern wird.
THE PECULIARITIES LOCAL IMMUNE REACTIONS IN ILEUM AT POSTRESECTION PORTAL HYPERTENSION
Authors: L. V. Tatarchuk  , M. S. Hnatyuk
Published: November 2021

In the experiment, in laboratory white male rats, local immune reactions were investigated in the ileum in conditions of postresection portal hypertension, which was modeled by removing 58.1% of liver parenchyma. It has been established that postresection portal hypertension leads to pronounced changes in local immune reactions in the ileum, characterized by a 29.6% reduction in secretory IgA, a plasmoncytes with IgA on 1 mm² on the mucosa by 32.5%, an uneven, disproportional increase in the number of plasmatic cells with IgM. IgG, IgE, respectively, by 77.0%, 4.1 and 5.1 times. The cell density of the infiltrate in the mucosa of the investigated organ increased by 37.0%, and the number of mast cells by 35.8%. The results obtained indicate that postresection portal hypertension leads to weakening, tension and instability of the local immune homeostasis of the ileum mucosa and marked structural changes in the wall of the investigated organ.
CLINICAL ANATOMY OF THE EYE SOCKET
Authors: O. P. Kuchuk  , D. V. Pronyayev  , T. B. Sykyrytsʹka
Published: November 2021

Scientific literature review deals with the issues concerning the peculiarities of the eye socket clinical anatomy. Both common data concerning the peculiarities of the eye socket structure and the results of certain modern studies have been analyzed and structured, which will be useful for both students, teachers and practicing physicians. All the names of anatomical structures are given according to the International Anatomical Nomenclature in the Ukrainian language with Latin equivalents.
MORPHOMETRIC CHARACTERISTICS OF TEMPOROMANDIBULAR JOINT IN HUMAN DURING THE SECOND TRIMESTER OF INTRAUTERINE DEVELOPMENT
Authors: Stoliar D. B. , Lavriv L. P.
Published: November 2021

The article provides data on the anatomical features of temporomandibular joint in the second trimester of fetal development, certain methods of anatomy, morphometry and craniometry. The glenoid fossa in fetuses aged 4-6 months was found to be flat. The bone substance in the glenoid fossa is thin. One can see the development of the elements of the synovial membrane in the articular capsule. In the lower and upper parts of the articular cavity, the folds and ligaments of the connective tissue plate are identified, and the capillaries grow into the synovial membrane. In some places there are connective tissue membranes between the surfaces of the temporal bone and the articular disk, the articular disk and the head of mandible. Macroscopically, the articular disk has a dense structure, it is arranged between the articular surfaces, from the back surface of the articular disk to the inner surface of the articular capsule the taenia of the connective tissue is identified. Anteriorly, the articular disk is attached in the area of the future articular tubercle. The right and lefts temporomandibular joint are of the same size. In the dynamics of the second trimester of intrauterine development, the temporomandibular joint is characterized by the presence of a flat glenoid fossa and the absence of an articular tubercle. An increase in all craniometric indices is observed, indicating an increase in the total bone mass of the skull and an increase in the size of the temporomandibular joint.
Not pharmacological approaches to treatmentof intestinal gripes in children of first months
Authors: Loshak O.O. , Petritsuyk T.V. , Zbrozhyk E.V.
Published: November 2021

Colic are the greatest pain that is tested by new-born. Usually the attacks of colics pass independently to 5-6 month. In 5% cases the symptoms of colics testify to illness. When to raise an alarm: repaated vomiting, change of excrement (constipation, diarrhoea), anomalous temperature, protracted languor, bad weight gain ( less than 15 g/day). Criteria of choice of method for cut short of colic: the rapid offensive of effect, perfect security for a child, price availability. Oil from swelling of stomach Weleda can be used from the first days of life, effect shows up in the flow of 3-5-min, does not contain chemical and medicine components (spasmolytics, simeticon), does not have side effects and contra-indications.
Prophylactic OF THROMBOPHILIC COMPLICATIONS IN PREGNANT women WITH METABOLIC SYNDROM
Authors: Dyndar O. , Benyuk V. , Kurochka V. , Semenyuk A.
Published: November 2021

The role of thrombophilia in pathogenesis of main obstetrics aftereffects of illness in women with metabolic syndrome has been studied out. The flow of pregnancy, childbirth and puerperal period in women with metabolic syndrome and genetic determinate hypofibrinolysis and multigens form of thrombophilia were analysed. The main concepts of the pregnancy preparations has been worked out. Pathologically grounded prophylactics with using low-molecular geparin, vitamins and antioxidants for women with metabolic syndrome was worked out.
COMORBID CONDITIONS IN OBESITY IN CHILDREN AND ADOLESCENTS AND MODERN TECHNOLOGIES OF THEIR DIAGNOSIS
Authors:   Siberian State Medical University (SSMU), Tomsk, Russia, Samoilova Yu.G. , Kovarenko M.A. ,   Siberian State Medical University (SSMU), Tomsk, Russia, Oleynik O.A. ,   Siberian State Medical University (SSMU), Tomsk, Russia, Kudlay D.A. ,   National Research Center Institute of Immunology of the Russian Federal Biomedical Agency, Moscow, Russia,   I.M. Sechenov First Moscow State Medical University, Moscow, Russia, Diraeva N.M. ,   Siberian State Medical University (SSMU), Tomsk, Russia, Podchinenova D.V. ,   Siberian State Medical University (SSMU), Tomsk, Russia, Matveeva M.V. ,   Siberian State Medical University (SSMU), Tomsk, Russia, Denisov N.S. ,   Siberian State Medical University (SSMU), Tomsk, Russia
Published: November 2021

The review presents modern views of not only the long-known comorbid conditions and obesity in children and adolescents, including arterial hypertension, dyslipidemia, steatohepatosis, impaired carbohydrate tolerance and type 2 diabetes, but also less studied comorbid associations with overweight in childhood: ectopic deposition of fatty tissue, reproductive and psychological disorders, orthopedic problems and disorders of the gastrointestinal tract. It is emphasized that only a comprehensive interdisciplinary approach to the observation and treatment of obesity can help in the development and implementation of a personalized and therefore more effective selection of therapeutic and preventive interventions.
INTUSSUSCEPTION AS A CAUSE OF NECROTIZING ENTEROCOLITIS IN A PREMATURE NEWBORN
Authors:   Tyumen State Medical University, Tyumen, Russia, Akselrov M.A. ,   Tyumen Regional Clinical Hospital No. 2, Tyumen, Russia, Suprunets S.N. ,   Tyumen State Medical University, Tyumen, Russia,   Tyumen Regional Clinical Hospital No. 2, Tyumen, Russia, Sergienko T.V. ,   Tyumen Regional Clinical Hospital No. 2, Tyumen, Russia, Emelyanova V.A. ,   Tyumen Regional Clinical Hospital No. 2, Tyumen, Russia, Sudareva D.I. ,   Tyumen Regional Clinical Hospital No. 2, Tyumen, Russia
Published: November 2021

A rare clinical case demonstrates the difficulty of diagnosing intussusception in preterm infants. As it is often misdiagnosed as NEC, and surgery gets delayed. Distinguishing between NEC and intussusception in preterm infants when they coexist can be difficult as these conditions share common symptoms.
ENDOSCOPIC TREATMENT OF HEREDITARY PANCREATITIS IN A CHILD WITH JUVENILE IDIOPATHIC ARTHRITIS: CLINICAL CASE REPORT AND LITERATURE REVIEW
Authors:   Central Clinical Hospital with Polyclinic of the Office of the President of the Russian Federation, Moscow, Russia, Sokolov Yu.Yu. ,   Russian Medical Academy for Continuous Professional Education, Moscow, Russia, Solodinina E.N. ,   Central Clinical Hospital with Polyclinic of the Office of the President of the Russian Federation, Moscow, Russia, Efremenkov A.M. ,   Central Clinical Hospital with Polyclinic of the Office of the President of the Russian Federation, Moscow, Russia,   Russian Medical Academy for Continuous Professional Education, Moscow, Russia, Chekmazov I.A. ,   Central Clinical Hospital with Polyclinic of the Office of the President of the Russian Federation, Moscow, Russia, Stepanov A.A. ,   Central Clinical Hospital with Polyclinic of the Office of the President of the Russian Federation, Moscow, Russia, Fomicheva N.V. ,   Central Clinical Hospital with Polyclinic of the Office of the President of the Russian Federation, Moscow, Russia, Glazyrina A.A. ,   Morozov Children’s City Clinical Hospital, Moscow, Russia, Jilavyan M.G. ,   Central Clinical Hospital with Polyclinic of the Office of the President of the Russian Federation, Moscow, Russia
Published: November 2021

The severe course of chronic pancreatitis (CP) in children is rare. More often it is caused by hereditary factors and abnormalities of the bile and pancreatic ducts. Cases of the development of pancreatitis against the background of systemic inflammatory diseases are described. Therapy of a systemic disease can aggravate the course of pancreatitis, and the general serious condition of the patient does not allow for the necessary surgical treatment. The article describes the clinical case report of a complicated course of CP against the background of juvenile idiopathic arthritis in a 17-year-old girl. The effectiveness of intraluminal endoscopic methods of treatment (wirsungotomy and stenting of the main pancreatic duct) for relieving exacerbation and complications of CP has been demonstrated.
MODERN VIEWS ON GASTROESOPHAGEAL REFLUX DISEASE IN CHILDREN: ISSUES OF CLASSIFICATION, ETIOLOGY AND PATHOGENESIS (PART I)
Authors:   Scientific Center for Pediatrics and Pediatric Surgery, Almaty, Kazakhstan, Akhparov N.N. , Boranbaeva R.Z. ,   Scientific Center for Pediatrics and Pediatric Surgery, Almaty, Kazakhstan, Suleimanova S.B. ,   Scientific Center for Pediatrics and Pediatric Surgery, Almaty, Kazakhstan, Manzhuova L.N. ,   Scientific Center for Pediatrics and Pediatric Surgery, Almaty, Kazakhstan
Published: November 2021

The review is devoted to modern views on the etiology, pathogenesis, clinical picture, methods of diagnosis and surgical treatment of gastroesophageal reflux disease (GERD) in children. An analysis of scientific literature by domestic and foreign authors on the evolution of molecular genetic and cytogenetic studies, the role of morphological and immunohistochemical mechanisms in diagnostics is presented, the researchers’ opinions regarding the timing and tactics of surgical intervention, as well as the advantages of minimally invasive surgery for GERD are considered.
APPLICATION OF BRAIN NEUROIMAGING TECHNOLOGIES FOR CHILDHOOD OBESITY
Authors:   Siberian State Medical University (SSMU), Tomsk, Russia, Oleynik O.A. , Kudlay D.A. ,   I.M. Sechenov First Moscow State Medical University, Moscow, Russia,   National Research Center Institute of Immunology of the Russian Federal Biomedical Agency, Moscow, Russia, Samoilova Yu.G. ,   Siberian State Medical University (SSMU), Tomsk, Russia, Matveeva M.V. ,   Siberian State Medical University (SSMU), Tomsk, Russia, Podchinenova D.V. ,   Siberian State Medical University (SSMU), Tomsk, Russia, Tonkikh O.S. ,   Siberian State Medical University (SSMU), Tomsk, Russia, Ratkina K.R. ,   Siberian State Medical University (SSMU), Tomsk, Russia, Tolmachev I.V. ,   Siberian State Medical University (SSMU), Tomsk, Russia
Published: November 2021

The problem of obesity among children and adolescents is becoming more and more significant every year due to the increasing prevalence and its complications. Altered brain functioning is noted in obesity and contribute to eating behavior as well as the brain-gastrointestinal tractvisceral fat axis. This literature review is focuses on the issues of neuroimaging studies of the brain in obesity in childhood and the possibilities of various methods in the diagnosis and prediction of disorders. Medline and Cochrane Central Register of Controlled Trials (CENTRAL) databases from 2000 to 2021 were used for the literature search.
RUBINSTEIN-TEIBI SYNDROME
Authors:   Academician N.P. Bochkov Research Centre of Medical Genetics (RCMG) of the Russian Academy of Sciences, Moscow, Russia, Ismagilova O.R. ,   Pirogov Russian National Research Medical University, Moscow, Russia, Beskorovainaya T.S. ,   Academician N.P. Bochkov Research Centre of Medical Genetics (RCMG) of the Russian Academy of Sciences, Moscow, Russia, Adyan T.A. ,   Academician N.P. Bochkov Research Centre of Medical Genetics (RCMG) of the Russian Academy of Sciences, Moscow, Russia,   Pirogov Russian National Research Medical University, Moscow, Russia
Published: November 2021

Rubinstein-Teibi syndrome (RTS) is a multisystem pathology characterized by mental retardation and delayed physical development combined with characteristic external manifestations that make up a recognizable picture of the disease. The literature review highlights the clinical manifestations of RTS, considers the issues of geno-phenotypic correlations and differential diagnostics, describes the possibilities and prospects of diagnostics and treatment, taking into account the results of modern research.
The Influence of Brand Specific Stimuli on the Perception of Music. An Experimental Approach
Authors:   Babes-Bolyai University, Cluj-Napoca, Romania, CHEȚAN Adrian , IANCU Ioana ,   Babes-Bolyai University, Cluj-Napoca, Romania
Published: November 2021

In an increased competitive market, the way music performers build their brand identity becomes of great importance. Starting from a gap in the literature, the present study aims to investigate the correlations between the existence of a visual identity of a singer and the perception of the singer’s song. Thus, the research inquires if the presence of visual brand elements can generate a better attitude on the song, stronger emotional reactions and attachment, and a deeper intentional behavior in terms of listening to the song again and recommending it to others. A 1x2 online survey-based experimental design has been developed. Contrary to expectations, the data reveal neither strong, nor significant relationships between most of the above-mentioned variables. However, being an impactful topic for the music specialists, research directions that can be further investigated have been emphasized.
The effects of isolates and immune function on hematologic parameters of Blastocystis infection rats
Authors: Deng Ting , Li Juan , Li Xiaohua , Li Xiaobo , Yan Yiming
Published: November 2021

Objective: To define a complex of changes in hematologic parameters associated with subtypes (ST) of Blastocystis sp. infections and the status of immune function in Sprague Dawley (SD) rats, and lay the foundation for Blastocystis hominis pathogenesis research. Methods: 5 isolates of ST1, ST3 and ST7 were used, including 1 isolate of ST1 from symptomatic patient, 2 isolates of ST3 and ST7 from symptomatic patients and asymptomatic carrier separately. Immune compromise model was set up using dexamethasone (DEX) and infection models with 5 isolates of ST1, ST3 and ST7, and then examined the hematologic changes post infection 15 days using fully automatic hematology analyzer sysmex xe-2100. Results: The results showed that infections of Blastocystis STs leaded to the increase of platelet indexes including MPV and PDW except ST3 isolated from asymptomatic carrier only with PDW increase and the higher values of PLT in ST7 isolated from asymptomatic carrier compared with the controls in the immune competence status (P < 0.05). However, the infections of Blastocystis ST7 isolated from symptomatic patient gave rise to higher values of WBC, LYMP, EO, MCV and RDW-SD while lower values of NEU% compared with the controls in immune compromise status (P < 0.05). Meanwhile, higher values of WBC and LYMP and lower NEUT% values were observed in ST1 infections compared with the controls (P < 0.05); lower NEUT values in ST1 infections and controls compared with ST3 and ST7 respectively were observed (P < 0.05); the infection of ST3 isolated from symptomatic patient resulted in higher values of MCV and RDW-SD while the asymptomatic isolate of ST3 only had higher RDW-SD (P < 0.05). Conclusion: The virulence of Blastocystis sp. isolated from symptomatic patient is higher than that of the identical subtype one isolated from asymptomatic carrier. The infection of ST7 isolated from symptomatic patients may result in the most distinct hematologic changes among STs, and then followed by ST1 symptomatic isolate. And the severity of Blastocystis sp. infection may be mediated by the immune status of host.
Research progress in immunotherapy of advanced non-small cell lung cancer
Authors: Lu Xiaojuan , Shi Huaqiu , Que Qiuyang , Qiu Song
Published: November 2021

Non-small cell lung cancer (NSCLC) poses a serious threat to people’s health. Its morbidity and mortality are among the highest among all malignant tumors, and there is an urgent need for more effective new treatment methods. In recent years, NSCLC immunotherapy has made great progress, the first PD-1 inhibitor nivolumab (Nivolumab, O drug) was approved by the US Food and Drug Administration (FDA) in March 2015, applying to the patients who progressed or has received platinum chemotherapy drugs in the past. Immunotherapy of advanced NSCLC has entered a new era. This article reviews the current research progress of NSCLC immunotherapy.
Research progress of NK cell immunodeficiency in immune escape of acute leukemia
Authors: Zhang Yuling , Yu Zhong , Li Hailiang
Published: November 2021

NK cell immunodeficiency has a variety of manifestations and complex mechanisms in the tumor. NK cell immune deficiency is closely related to immune escape of acute leukemia. This paper demonstrates the immunological escape mechanism of acute leukemia from NK cell immune deficiency manifestation and cause.
The correlation between Serum phospholipase A2 receptor antibody and clinicopathological features in patients with membranous nephropathy
Authors: Huang Qipeng , Xu Gaosi , Wang Fang , Zeng Fang , Fang Weidong
Published: November 2021

Objective: To assess the correlation between Serum phospholipase A2 receptor antibody and clinicopathological features in patients with membranous nephropathy. Method: The patients being hospitalized for renal biopsy were selected in this study from January 2016 to January 2018. And normal controls were randomly selected; all the patients were divided into idiopathic membranous nephropathy and non-idiopathic membranous nephropathy groups; patients with idiopathic membranous nephropathy were divided into three groups, namely stage I, stage II and stage III; using software for statistical analysis. Results: A total of 357 patients were enrolled, including 155 patients with idiopathic membranous nephropathy, 183 patients with non-idiopathic membranous nephropathy, and 19 cases for normal controls. The average age of the idiopathic membranous nephropathy (IMN) group is higher than that of the membranous nephropathy group (P = 0.01). Different pathological stages of idiopathic membranous nephropathy general clinical characteristics analysis results showed that the age, cys c, serum creatinine (Scr) in stage III membranous nephropathy group were higher than those of the stage I and II membranous nephropathy (P values were 0.003, 0.000 and 0.000 respectively); titers of serum phospholipase A2 receptors antibody with stage II and III membranous nephropathy higher than the stage I membranous nephropathy group (P = 0.006); serum albumin (Alb) levels correlated inversely with serum anti-PLA2R antibody titers (rs = –0.234, P = 0.003), serum antiphospholipase A2 receptor (PLA2R) antibody titer level in patients with idiopathic membranous nephropathy was significantly higher than that in patients with non-membranous nephropathy (P < 0.001). Conclusion: Baseline titer of serum anti-PLA2R antibody is negatively correlated with Alb in the IMN patients，and serum anti-PLA2R antibody level in patients with stage I IMN was significantly lower than stage II and III IMN patients.
Research progress in immunological mechanisms of Cryptococcus
Authors: Song Ying , Qiu Yufang , Liu Weiyou , Yuan Xiaoliang
Published: November 2021

Whether infection of Cryptococcus causes disease in host or not depends on the virulence of the pathogen and the immune defense ability of the host. Cryptococcus neoformans (C. neoformans) mainly causes opportunistic infections in the immunocompromised or immunodeficient patients. In contrast, Cryptococcus gattii (C. gattii) mainly attacks the immunocompetent individuals. On the one hand, the host immune cells can eliminate the invasive Cryptococcus through a complex immune mechanism; on the other hand, Cryptococcus can evade the clearance of host immune cells by adopting various strategies (immune escape). This review mainly focuses on the pathogenic mechanism of Cryptococcus, and the host’s immune defense mechanism against cryptococcal infection.
Studies on the proliferation inhibition effects of TUA from Actinidia chinensis Radix on lung cancer xenografts in nude mice and its preliminary mechanism
Authors: Guo Xiaohua , Hu Haibo , Jin Qi , Li Hongliang , Cheng Qilai
Published: November 2021

Objective: To investigate inhibitory effect of TUA (2β, 3β, 23-trihydroxy-urs-12-en-28-oic acid) isolated from Actinidia chinensis Radix on the lung cancer xenografts in nude mice and explore its preliminary mechanism. Methods: NCI-H460 cells were implanted into nude mice and the transplantation tumor block from nude mice of more than 2 generations was inoculated to the right armpits of BALB/c mice with dissecting needle to establish a lung cancer xenograft model. When the transplanted volume was about 50 mm3, the mice were randomly divided into 6 groups: (1) model group; (2) 10 mg·kg–1 cisplatin group; (3) 10 mg·kg–1 PDTC group; (4) TUA high dose group (30 mg·kg–1); (5) TUA middle dose group (12 mg·kg–1); (6) TUA low dose group (6 mg·kg–1). Administration approach was intratumoral injection. The effects of each group on the weight of transplanted tumor animals, the volume and weight of tumor were continuously observed for 14 days. Tumor volume growth curve was drawn and tumor inhibitory rate and index were calculated; HE staining was used to observe nude mice tumor tissue pathological changes. The effects of TUA on NF-κB signaling pathway related proteins were detected by immunohistochemistry and Western blot. Results: In vivo experiments showed that the transplanted tumors in nude mice became smaller compared with the models. With the increase of TUA dose, the tumor tissue became smaller and smaller, especially in high TUA dose (30 mg·kg–1). It had the similar size with the NF-κB inhibitor PDTC (10 mg·kg–1) group. HE dyeing observation results confirmed the degree of tumor necrosis and fission in TUA treated tumor tissues obviously decreased. Immunohistochemical results showed that comparing the TUA treatment group with the model group, p65 expression in tumor tissues was reduced, and expression of IκBα increased. Western blot results also showed that the NF-κB related p65 protein expression levels decreased, at the same time IκBα protein expression level increased; the apoptosis related proteins Survivin protein expression was depressed, Caspase-3 protein expression was promoted. Conclusion: TUA significantly inhibits the growth of lung transplantation tumor and its mechanism. It may be related to the decreasing the expression of p65, Survivin and increasing the expression of IκBα, Caspase-3 in tumor tissues.
Combining PD-1/PD-L1 inhibitor and PARP inhibitor: a new perspective on the treatment of triple negative breast cancer
Authors: Xie Ruilian
Published: November 2021

Compared with other types of breast cancer, triple negative breast cancer has a poor survival prognosis due to its high aggressiveness and lack of effective therapeutic targets. Immune checkpoint (PD-1/PD-L1 and CTL-4) inhibitors have emerged as a breakthrough therapy in the treatment in various metastatic cancers. PARP inhibitors promote DNA damage in tumor cells, not only promoting immune initiation through a series of molecular mechanisms, but also leading to adaptive upregulation of programmed death ligand 1 (PD-L1) expression. Therefore, the combination of the two inhibitors can improve the efficacy of tumor treatment. We reviewed the research progress of their combined use in triple negative breast cancer, and put forward relevant ideas for further development, hoping to find the best treatment mode of the combined use of the two.
The expression and significance of 8-hydroxydeoxyguanosine in breast cancer patients’ blood, urine and cancer tissue
Authors: Liu Zhiyong , Yi Jian , Liu Feng’en
Published: November 2021

Objective: To explore the expression and clinic significance of 8-OHdG in breast cancer. Methods: Pre-operative serum 8-OHdG levels were detected with an enzyme-linked immunosorbent assay in a well-defined series of 173 breast cancer patients. 8-OHdG expression in cancer cells from 150 of these patients was examined by immunohistochemistry. The HPLC-ECD method is used to determine 8-OHdG concentration in urine. Results: The serum 8-OHdG levels and immunohistochemical 8-OHdG expression were in concordance with each other (P < 0.05, r = 0.163). Breast cancer patients with negative 8-OHdG immunostaining show lower survival rate according to the multivariate analysis (P < 0.01). This observation was even more remarkable in ductal carcinomas (n = 140) patients (P < 0.001). A low serum 8-OHdG level was associated statistically significantly with lymphatic vessel invasion and a positive lymph node status. Comparison of 8-OHdG concentration in urine of breast cancer patients and healthy women was statistical significance (P < 0.01). Conclusion: Low serum 8-OHdG levels and a low immunohistochemical 8-OHdG expression were associated with an aggressive breast cancer phenotype. In addition, negative 8-OHdG immunostaining was an independent prognostic factor for breast cancer-specific death in breast carcinoma patients. Using 8-OHdG concentration in urine to predict DNA damage resulting from breast cancer can provide good biological indicators for detecting harm in early breast cancer.
Effect of 1.25(OH)2D3 on experimental autoimmune neuritis and its mechanism
Authors: Nian Di , Li Zhuohan , Sun Junjie , Shi Peng
Published: November 2021

Objective: To study the potential therapeutic effects of active vitamin D3 (1.25(OH)2D3) in the experimental autoimmune neuritis (EAN). Methods: The EAN model was established by actively immunizing Lewis rats with synthetic P0180–199 pepide and Freund’s complete adjuvant. 1.25(OH)2D3 treatment was given, weight change of rats and clinical score were analyzed. HE staining was used to detect the inflammatory cell infiltration of sciatic nerves and demyelination of sciatic nerves was observed by transmission electron microscope (TEM) at the same time. The expressions of inflammatory cytokines IL-17, IL-10, TGF-β, IFN-γ were detected by ELISA, and the expressions of Th17, Treg were examined by RT-PCR. Results: 1.25(OH)2D3 ameliorated body weight loss and myelin lesions. It decreased expressions of inflammatory cytokines IL-17, IFN-γ and RORrt while those of IL-10, TGF-β and FoxP3 were increased. Conclusions: 1.25(OH)2D3 can improve the clinical pathological changes of EAN rats, and the mechanism may be related to the changes of inflammatory cytokines. 1.25(OH)2D3 is expected to become a new strategy for the clinical treatment of GBS/EAN.
Combination of anti-angiogenic therapy Apatinib and immune therapy potentiate tumor microenvironment
Authors: Gao Chunyi , Hu Tianhui
Published: November 2021

Tumor immune therapy, especially anti-programmed cell death ligand-1/programmed cell death-1 (PD-L1/PD-1) treatment, is currently the focus of substantial attention. However, despite its enormous successes, the overall response rate of cancer immunotherapy remains suboptimal. There is an increased interest in combining PD-L1/PD-1 treatment with anti-angiogenic drug Apatinib to enhance antitumor effect. Presently available data seem to suggest that Apatinib may exert immune suppressive effects to make the PD-L1/PD-1 treatment works. Here, we review the extensive tumor microenvironment immune modulatory effects from antiangiogenic agents Apatinib in order to supporting VEGFR2 targettherapies in clinical trials are existing.
Inflammaging in skin and intrinsic underlying factors
Authors: Aioi Akihiro
Published: November 2021

Aging of organs starts from the time of birth and continues throughout life. Aging of skin can be divided into two distinct types—intrinsic aging and extrinsic, based on the fact that the skin is the outermost organ exposed to the external environment. However, despite their different histological features and triggers, intrinsic and extrinsic aging share common biochemical mechanisms. β-galactosidase, p16INK4a, and senescence-associated secretory phenotype (SASP) factors are detected in skin cells as biomarkers of senescence. In particular, inflammatory cytokines, the constituents of SASP, play pivotal roles in “inflammaging” which is a concept involving the relationship between aging and low-grade inflammation. In this review, the features of skin aging and its underlying mechanism of skin aging are summarized.
The Competitive Advantages of Multi-Family Offices over Banks in Serving Wealthy Clients in Poland
Authors: Kozinska Magdalena
Published: November 2021

In Poland, the main players in serving wealthy clients are banks. Nevertheless, the number of multi-family offices (MFOs) has increased notably, raising questions whether they can become real competitors to the private banking divisions. Therefore, an analysis of the activity profile of multi-family offices and private banking in Poland was conducted. Additionally, a survey of multi-family offices enabled the evaluation of their perceived competitive positions. The level of development of MFOs in Poland is low and their market is in its infancy. MFOs operating in Poland are, however, considerably more flexible than banks operating in the field of private banking.
La psiquiatría fenomenológica de la esquizofrenia según Thomas Fuchs
Authors: De Barrio Rosa María
Published: November 2021

Resumen

Esta investigación trata sobre la esquizofrenia como trastorno de la intercorporalidad. Ésta según Thomas Fuchs, sucesor de Karl Jaspers en la cátedra, y como él, psiquiatra y filósofo, no es un trastorno ni primariamente cognitivo ni neurológico, sino de la intersubjetividad encarnada. Al explorar esta tesis, desarrollaremos gran parte de los conceptos de la antropología filosófica elaborada por Fuchs: resonancia corpórea, transparencia corpórea, intercorporalidad e interafectividad.
Conceptos filosóficos que influyeron en las paradojas de conjuntos descubiertas por Bertrand Russell
Authors: Maya Restrepo Felipe
Published: November 2021

En este artículo examino algunos presupuestos filosóficos de Bertrand Russell que subyacen a su descubrimiento de las paradojas en la teoría de conjuntos de Cantor: los juicios a priori y sintéticos de Kant, el logicismo de Leibniz, la cosmovisión hegeliana, el argumento ontológico de san Anselmo.
Cuerpo, Alma y Espíritu. Ensayo filosófico.
Authors: García Martínez José Domingo
Published: November 2021

Reseña dedicada a la obra de Salvador Anaya. Invitación a entender la conciencia en clave fenomenológica.
Sobre el significado de la selección natural
Authors: Alemañ Berenger Rafael Andrés
Published: November 2021

La selección natural es una de las claves fundamentales de la biología evolutiva, que es tanto como decir de casi todas las ciencias de la vida. No obstante, el esfuerzo por aquilatar su verdadero significado se ha visto envuelto en inacabables controversias casi desde el comienzo. El replanteamiento de la selección natural mediante un esquema abstracto con tres ingredientes –población, entrono e interacción entre ellos– podría contribuir sensiblemente a aclarar este debate.
The effects of recreational cannabis access on labor markets: evidence from Colorado
Authors: Chakraborty Avinandan , Doremus Jacqueline , Stith Sarah
Published: November 2021

Recreational cannabis markets possibly increase labor demand through investments in facilities for growing, processing, and retail sales of cannabis, as well as through other industries such as manufacturing, leisure, and hospitality. However, this increase in labor demand may vary substantially across counties within a state as most states with legal recreational cannabis allow individual counties to ban commercial cannabis sales. Meanwhile, labor supply may change through positive and negative effects from cannabis use. Using county-level Colorado data from 2011 to 2018 and exploiting variation across counties in the existence and timing of the start of dispensary sales, we test for changes in the unemployment rate, employment, and wages, overall and by industry subsector. Consistent with an increase in labor demand, we estimate that the sale of recreational cannabis through dispensaries is associated with a 0.7 percentage point decrease in the unemployment rate with no effect on the size of the labor force. We also find a 4.5% increase in the number of employees, with the strongest effects found in manufacturing. We find no effect on wages. Given the lack of a reduction in labor force participation or wages, negative effects on labor supply are likely limited, in line with the existing literature. The decrease in unemployment, coupled with an increase in the number of employees, indicates that labor demand effects likely dominate effects on labor supply. Our results suggest that policymakers considering recreational access to cannabis should anticipate a possible increase in employment.
Sub-cellular elemental imaging of human muscle tissues affected by neuromuscular diseases
Authors: Śliż-Szpytma Patrycja , Lankosz Marek , Dudała Joanna , Adamek Dariusz , Radwanska Edyta , Kwinta Borys , Jakšić Milko , Božičević Mihalić Iva , Provatas Georgios
Published: November 2021

Various types of neuromuscular diseases differ in symptoms, pathology, and clinical picture but one of their common elements is muscle weakness, which could lead to human motor activities impairment and in many cases to shortening of life span and even death due to respiratory failure. That is why it is very important to better understand the underlying causes of these diseases to be able to implement new methods of treatment more effectively. This paper presents the results of the elemental analysis of human muscular tissues affected by dystrophy and myopathy. For this purpose, the particle-induced X-ray emission method was used, which is perfectly suited for measuring light elements. The samples were analysed for differences in the elemental composition of Na, Mg, P, S, Cl, K, Fe, Zn, and Br. The results were presented in the form of elemental concentration maps and a thorough statistical analysis of the obtained data using the advanced statistical methods.