bluuebunny/crossref_metadata_2025 huggingface dataset:
Mycobacterial virulence: impact on immunogenicity and vaccine research
Authors: Kroesen Vera M. , Madacki Jan , Frigui Wafa , Sayes Fadel , Brosch Roland
Published: November 2019

The borderline between virulence and efficacy in live attenuated vaccine strains is often blurred and this is also the case for the Bacillus Calmette–Guérin (BCG), the only currently licensed anti-tuberculosis vaccine used on a large, global scale, which was obtained almost 100 years ago. While BCG is more than 99% identical at the genome level to Mycobacterium tuberculosis, the causative pathogen of human tuberculosis, some important differences in virulence factors cause naturally irreversible attenuation and safety of this vaccine in the immunocompetent host. Some of these virulence factors are involved in persistence capacities of the vaccine strains and also represent strong immunogens, responsible for inducing different host signaling pathways, which have to be taken into consideration for the development of revised and new vaccine strains. Here we discuss a number of selected mycobacterial features in relation to their biological functions and potential impact on virulence and vaccine efficacy.
Treatment of Buerger’s disease (Thromboangiitis obliterans) with autologous adipose tissue-derived mesenchymal stem cell: Report of three cases
Authors: Jeong Sun Teak , Ra Jeong Chan
Published: November 2019

Buerger’s disease or Thromboangiitis obliterans is an orphan vascular disease that most commonly affects nerves, small or medium-sized vessels in the upper and lower extremities, and is characterized by a non-atherosclerotic, segmental, inflammatory disorder. The etiology and the pathogenesis of the disease have not been fully elucidated. Although various interventions have been adopted recently, there is still no effective treatment for the prevention of the progression of the disease. This report presents three clinical cases that show the efficacies of autologous adipose tissue-derived mesenchymal stem cell (AdMSC) treatment in Buerger’s disease. Three male patients diagnosed with Buerger’s disease were between 46 and 55 years and had a smoking history. AdMSCs (5X106 cells/kg body weight) were injected intramuscularly into at least 38 points of the ischemic legion of the lower limb at one time. The patients were checked for safety and efficacy at one, three, and six months after AdMSC injection. No severe adverse events and no adverse drug events were observed in physical examination, vital signs, and laboratory tests for all three patients. Ulcers in the affected legs of the patients were healed completely after the treatment. Visual Analogue Scale scores and all the criteria (activities, emotional, pain, social, symptoms and total) of the King's College Hospital's Vascular Quality of Life Questionnaire (VascuQOL) of all the patients were improved from baseline to six months follow-up. Digital Infrared Thermal Imaging showed the gradual alleviation of lesions in the leg. Angiogenesis in the affected limbs was identified by CT-Angiography after AdMSC injection. The present cases show the improvement in patients with Buerger’s disease with the observation of angiogenesis after intramuscular injection of autologous AdMSCs. This suggests that autologous AdMSC can be an effective alternative treatment for Buerger’s disease.
Case Report: Successful use of fondaparinux in a case of heparin intolerance during pregnancy
Authors: AlSheef Mohammed , Shafi Noura , Aleid Bakhitah , Zaidi Abdul Rehman Zia , AlArfaj Ohoud
Published: November 2019

Heparin is the anticoagulant of choice during pregnancy. However, in cases of intolerance or adverse effects, another anti-coagulant agent should be administered. Here, we describe a case of hypersensitivity skin reaction seen in a 37-year-old pregnant patient at 11 weeks of gestation who used low-molecular-weight heparin (LMWH). Fondaparinux was used as an alternative during her pregnancy with a successful outcome.
Knowledge gaps and research priorities in tuberculous meningitis
Authors: Seddon James A , Wilkinson Robert , van Crevel Reinout , Figaji Anthony , Thwaites Guy E ,   Tuberculous Meningitis International Research Consortium
Published: November 2019

Tuberculous meningitis (TBM) is the most severe and disabling form of tuberculosis (TB), accounting for around 1-5% of the global TB caseload, with mortality of approximately 20% in children and up to 60% in persons co-infected with human immunodeficiency virus even in those treated. Relatively few centres of excellence in TBM research exist and the field would therefore benefit from greater co-ordination, advocacy, collaboration and early data sharing. To this end, in 2009, 2015 and 2019 we convened the TBM International Research Consortium, bringing together approximately 50 researchers from five continents. The most recent meeting took place on 1stand 2ndMarch 2019 in Lucknow, India. During the meeting, researchers and clinicians presented updates in their areas of expertise, and additionally presented on the knowledge gaps and research priorities in that field. Discussion during the meeting was followed by the development, by a core writing group, of a synthesis of knowledge gaps and research priorities within seven domains, namely epidemiology, pathogenesis, diagnosis, antimicrobial therapy, host-directed therapy, critical care and implementation science. These were circulated to the whole consortium for written input and feedback. Further cycles of discussion between the writing group took place to arrive at a consensus series of priorities. This article summarises the consensus reached by the consortium concerning the unmet needs and priorities for future research for this neglected and often fatal disease.
Audit of risk-management methods in respect of their acceptance of analysis medical activity
Authors: Biryukov V.
Published: November 2019

The work is devoted to the analysis of accessibility, usefulness and the possibilities of introducing a number of risk management methods into medical institutions on the basis of the choice of heads medical institutions, after getting to know them with the main methods, proposed by the ISO 31000: 2009 standard. The conducted research has shown advantages of methods of "brainstorming" and the analysis of cause-effect relations by heads of medical institutions.
Maximal aerobic speed as a useful tool to understand specific training demand among elite male volleyball
Authors: Lakhdar Louglaib , Zerf Mohammed
Published: November 2019

Aim: The study aims to study the impact of Maximal Aerobic Speed (MAS) levels on the growth of skills fitness among volleyball. Methods: To achieve this objective, we assess the levels of MAS for 60 elite male volleyball players (ages 22 to 25 years with +5 years' experience in elite championships). Tested by volleyball Alberta tests and standing triple jump and T agility tests to estimate the effect of coordination abilities on players body adaptations to recover from the high-intensity and fatiguing actions as a result of levels of endurance. Results: Backup on statistics applied, centred on MAS levels as protocol. We confirmed that a high-level of MAS enhanced skills fitness. Admitted by the inverse correlation between the levels of MAS in compares with speed, power and explosive abilities. In the benefits of players with elevated levels of MAS as a beneficial condition to improve skills fitness (Serve-attack/Spike/Block) among volleyball players.
Conclusion: our protocol support the development of MAS at 4 + (m/s). Agreed as minimal components of physical condition allied to neuromuscular system adaptations, which permit players not only to improve their speed and power components. But also their ability to recover from high-intensity and fatiguing actions.
DAS UNHEIMLICHE OU "O ESTRANHO", DE FREUD
Authors: Soares Lenice Alves
Published: November 2019

Sigmund Freud publica, em 1919, um texto intitulado Das Unheimliche (O estranho / O inquietante), com a intenção de mostrar a causa do sentimento de estranheza nos seres humanos, tendo como base o conto O homem da areia, do autor alemão E. T. A. Hoffmann. O presente artigo tem como objetivo fazer um resumo comentado deste texto de Freud e mostrar a importância do mesmo para a teoria da ficção fantástica.
OS SONHOS FAMILIARES EM EL MATERIAL HUMANO (2009), DE RODRIGO REY ROSA
Authors: De Freitas Faqueri Rodrigo
Published: November 2019

Este artigo traz à tona um olhar sobre a literatura centro-americana a partir de um estudo realizado sobre o romance El Material Humano (2009), do escritor guatemalteco contemporâneo Rodrigo Rey Rosa. Como representante centro-americano, Rey Rosa apresenta as muitas faces de uma localidade imensamente rica para análises e estudos profundos, uma vez que seus textos possuem uma primorosa singularidade, construindo um projeto estético para ressignificar a identidade centro-americana e guatemalteca. Em El material humano (2009), encontra-se a história de uma personagem que consegue autorização para estudar os arquivos da Polícia Nacional Guatemalteca encontrados por acaso em um antigo hospital militar desativado. Entre sua busca pelos acontecimentos históricos que preenchem os arquivos da PNG e a sua vida, o protagonista se vê imerso em sonhos que lhe são extremamente familiares, mas que lhe causam um desconforto enorme exatamente por esta familiaridade e pela proximidade com a realidade em que ele está inserido. Assim, as indagações da personagem são sempre permeadas pelas suas experiências reais atreladas às situações consideradas do universo insólito.
ENTRE A ÁFRICA E A EUROPA: DESLOCAMENTO E FRAGMENTAÇÃO IDENTITÁRIA EM A MENINA ÍCARO, DE HELEN OYEYEMI
Authors: Bonatti Diego , Silva Denise Almeida
Published: November 2019

Resumo: A literatura pós-colonial, enquanto campo de estudos que investiga os problemas causados pelo imperialismo europeu, tem representado a dificuldade de localização cultural e identitária do sujeito pós-colonial. Nessa perspectiva, o objeto de análise escolhido para este trabalho é A Menina Ícaro, da escritora nigeriana-inglesa Helen Oyeyemi. A protagonista, Jessamy, é uma menina negra inglesa, filha de pai inglês e mãe nigeriana. Ela transita entre as culturas inglesa e nigeriana, sentindo-se deslocada em ambas. Assim, elegemos como objetivos deste estudo a investigação das questões de identidade cultural e deslocamento da protagonista em relação à África e à Europa, ressaltando a fragmentação identitária por ela apresentada. Para tanto, buscamos apoio teórico para o estudo de questões como identidade, deslocamento e migrância, principalmente no pensamento de Helena Callai (2004) e Stuart Hall (2005; 2003). Já sobre identidade migrante e fragmentação identitária partimos do pensamento de autores como: Pierre Ouellet (2012), e Sarah Ilott e Chloe Buckley (2016). Como resultados podemos destacar que: a) Jessamy não tem um lar fixo, já que esse espaço é preenchido tanto pela Nigéria, quanto pela Inglaterra, que têm elementos culturais presentes em sua vida; b) o trânsito entre duas culturas e a falta de vínculos identitários sólidos, leva a protagonista à crise identitária; c) como no mito grego de Ícaro, a protagonista é um sujeito em busca do encontro consigo mesma; a tentativa de harmonia com as duas identidades, entretanto, é fato impossível e indefinido no enredo, o que evidencia a complexidade da identidade do sujeito pós-colonial.
A PULSÃO DA ERRÂNCIA, O DEVIR-MULHER E A POTÊNCIA DA ARTE EM A DOCE CANÇÃO DE CAETANA
Authors: Da Silva Roniê Rodrigues
Published: November 2019

Este trabalho objetiva realizar uma leitura crítica do romance A doce canção de Caetana, da escritora contemporânea Nélida Piñon, associando o tema da errância à noção do devir-mulher e à ideia de potência representadas pela protagonista Caetana, uma fracassada atriz mambembe que perambula pelo interior do Brasil como herdeira de uma arte funâmbula, legatária de uma vida de ciganos, e que aparece na obra nelidiana intercambiando seu fazer artístico por ovos ou galinhas, a fim de sobreviver. Experienciando o que Michel Maffesoli (2001) denomina por efervescência dionisíaca, à parte de uma indústria cultural do entretenimento, é possível afirmar que Caetana e sua trupe manifestam o desejo por formas de subjetivação que escapam à ordem imperante das instituições de poder, encenando a aventura da existência por uma vivência anômica caracterizada pela desterritorialização, pela movência constante, e pela possibilidade de devir, conforme a discussão desenvolvida por Deleuze e Guattari (1997).
A IMPLEMENTAÇÃO DO ENSINO HÍBRIDO NO ENSINO DE INGLÊS DURANTE A FORMAÇÃO DOCENTE
Authors: Kieling Helena Dos Santos , Leffa Vilson José , Beviláqua André Firpo
Published: November 2019

Desenvolvemos o presente estudo com o objetivo geral de investigar a implementação do modelo Ensino Híbrido (em inglês Blended Learning) de Rotação em um curso de extensão de Língua Inglesa, ministrado por professoras em formação de uma Universidade Federal do Sul do Brasil. No que diz respeito aos objetivos específicos, pretendemos, com este estudo: a) Apresentar os modelos pedagógicos e epistemológicos que norteiam a atividade docente, com ênfase no uso pedagógico de tecnologias; b) Relacionar os modelos pedagógicos e epistemológicos apresentados a priori ao conceito de metodologias ativas, com destaque para o Ensino Híbrido; c) Avaliar em que medida os modelos epistemológicos e pedagógicos, juntamente com metodologias ativas como o Ensino Híbrido, podem potencializar o uso pedagógico de tecnologias na formação inicial de duas professoras. Os resultados mostram a importância da reflexão sobre o uso da tecnologia e de metodologias ativas no ensino da Língua Estrangeira embasados em uma concepção epistemológica relacional (BECKER, 2012) ainda durante a formação docente, bem como sugere a necessidade de mais pesquisas voltadas a esta área.
A IMPORTÂNCIA DOS MULTILETRAMENTOS NA FORMAÇÃO E NA PRÁTICA DOCENTE: A PIRÂMIDE HOLOGRÁFICA COMO UM RECURSO DIDÁTICO
Authors: Veiga Jaqueline Fonseca , Lopes Cristiane Rosa , Luterman Luana Alves
Published: November 2019

Este artigo apresenta uma experiência de ensino e de aprendizagem pautada nos multiletramentos e nas multimodalidades, que foi vivenciada em 2017, durante a regência do Estágio de Língua Portuguesa. Objetivamos ressaltar a importância do uso de metodologias e práticas de ensino multimodais e multimidiáticas, ressaltando os benefícios que elas podem trazer para desenvolvimento da aprendizagem. Com base nos estudos de Rojo (2012), Marzari (2014), entre outros autores, ressaltamos a importância da formação de professores tendo como base a pedagogia dos multiletramentos. Compreendemos que a formação continuada é um desafio para os professores, tendo em vista a carga horária de trabalho geralmente excessiva, e sabemos que a formação apenas da graduação não é suficiente. Portanto, encontramos, na internet e no YouTube, meios de ensinar e também de aprender, como foi a experiência com a pirâmide holográfica – um recurso inicialmente utilizado para fins de entretenimento, mas que foi didatizado, promovendo processos de aprendizagem multimodais e multimidiáticos.
Do you have 2020 vision?
Authors: Sharma Priya
Published: November 2019

What are your goals for the New Year? Priya Sharma talks new resolutions, new ambitions – and a new you
Breathing fire into kids' oral health care
Authors: Pattni Jenni
Published: November 2019

Dental nurse Jenni Pattni reveals how a cuddly dragon is helping oral health educators achieve magic results for patients in the Midlands
‘My brilliant career’
Authors: Schulze Katy
Published: November 2019

Katy Schulze shares her pathway over two decades – from dental nurse to practice manager – she believes she's found her dream job
Straight road to satisfaction
Authors: Silver Rebecca
Published: November 2019

Award-winning Rebecca Silver talks about joining orthodontic patients on a journey beyond the chair
Removal of Listeria monocytogenes Biofilm with Some Local Plant Extracts of Kurdistan Region
Authors: Mohammed Srwa A.
Published: November 2019

The results of removing or reducing biofilm were determined using subinhibitory concentrations (SICs) of some local plants in the flora of Kurdistan region of Iraq on biofilm production in Listeria monocytogenes. About 10–500 µg/ml of the plant extracts were used against growth and biofilm production in tissue culture plates which were measured spectroscopically. The SIC effects of each of Eugenia caryophyllata (Clove) and Rhus glabra (Sumac) have significantly affected on planktonic cells and reduced sessile cells or biofilm formation in L. monocytogenes. Remarkably, the data showed strong biofilm reduction under synergistically effect of the plant extract mixed with the antimicrobial agents in multidrugresistant L. monocytogenes. Whereas the SIC some of other plant extracts such as Salix candida and pomegranate (Punica granatum) have significantly enhanced biofilm expression in L. monocytogenes, but the use of these extracts synergistically with some antibiotics also resulted in inhibition of biofilm in comparison to merely use of either the extracts or antibiotics. The result of statistical analyses shows that P > 0.05. The results showed that the combination of plant extract with antibiotic together has more effect than using plant merely.
Synthesis of new series of Pyrazoline, and study their Kinetics and Reaction Mechanism
Authors: Kaka Kosrat N. , Taher Salam G. , Hamad Wali M. , Ibrahim Aram H.
Published: November 2019

A new series of novel pyrazoline compounds were synthesized by addition of thiosemicarbazide to the 2,6-dibenzylidenecyclohexanone (Chalcone) and its para substituted derivatives. This study was conducted for four purposes. Firstly, a series of five membered ring pyrazoline compounds were synthesized and the structure of all new products obtained are supported by spectral data (1H-NMR, 13CNMR, IR and UV-Vis.), and the effect of substituents were studied. Secondly, the reaction kinetics of the new synthesized compounds were studied to investigate the reaction mechanism pathway and order of the reaction; it was found that, the reaction undergoes via Claisen route of mechanism with first-order reaction. Thirdly, the thermodynamics of the reaction were studied, the rate of the reaction, Arrhenius parameters (A), and thermodynamic parameters for activation includes (free energies (Ea), entropies (ΔS#), and Gibbs free energy (ΔG#) were estimated. Finally, the compensation effect was also studied, and found the same pathway for all of the synthesized pyrazoline compounds.
L-Tryptophan as Fluorescent Probe for Determination of Folic Acid in Pharmaceutical Products
Authors: Tahir Tara F. , Qader Aryan F. , Salih Musher I. , Rashid Essa Q.
Published: November 2019

A new fluorescent probe L-Tryptophan was reported for the determination of folic acid (FA), based on its quenching effect of the fluorescence intensity of L-Tryptophan. The concentration of folic acid was proportional to the quenched fluorescence intensity of L-Tryptophan at an emission wavelength of 365 nm in Britton– Robinson (BR) buffer solution of pH 7. Optimized conditions of pH, time, order of addition of the reagent, potential interferences, concentrations of L-Tryptophan and buffer were investigated. Folic acid was determined in a linear range of 2.0 to 16.0 μg ml-1 with a correlation coefficient R2 0.9974. The limits of detection LOD and quantification LOQ values were 0.09 μg ml-1 and 0.27 μg ml-1, respectively. The standard deviation (RSD) values for five replicated measurements of 2, 8, 16 μg ml-1 folic acid were between 0.23 % and 1.07%. This method is efficient for routine analysis and quality control assay as it is relatively interferences free.
High-Performance Ultra-Compact Dual-Band Bandpass Filter for Global System for Mobile Communication-850/Global System for Mobile Communication-1900 Applications
Authors: Rezaei Abbas , Yahya Salah I.
Published: November 2019

This work presents a novel microstrip dual-band bandpass filter (BPF) using meandros spirals and patch cells, which is proposed for the first time by this work. It occupies a very compact size of 0.0017 λg2. The proposed filter is designed to operate at Fo1=0.85 GHz and Fo2=1.85 GHz for GSM-850/GSM-1900 applications. In addition to the small size, it has several advantages in terms of wide fractional bandwidths (FBW), low insertion losses and high return losses at both channels. The simulated insertion losses at the lower and upper passbands are 0.05 dB and 0.1 dB, respectively. Another advantage of the proposed BPF of this work is the attenuated harmonics, where it is able to suppress 1st, 2nd, 3rd and 4th harmonics (4.11 Fo1) with -20 dB maximum harmonic level.
Selection of Poverty Reduction Program through Community-Based Economic Empowerment in Madiun City
Authors: Andriani Dwi Nila , Wibawa Ramadhan Prasetya , Wihartanti Liana Vivin
Published: November 2019

Madiun City is one of the cities in East Java Province and is known as a city of trade and industry, Madiun community, in general, is a picture of modern society even though it is far from economic development in the capital city. Madiun is a city that has the potential to become an advanced economic center in the city of Madiun. Current conditions indicate that the unemployment rate and the quality of human resources in the city of Madiun are still low. Data from the Manpower Office of the city of Madiun noted that the number of unemployed people in the local area reached 5,700. Besides, people's economic strength has not developed optimally, and the index of public purchasing power is still low. In 2018 data from the Central Bureau of Statistics illustrates that poverty in Madiun City reached 4.49% or as many as 7.92 thousand people. One way to alleviate poverty in the city of Madiun is through community-based economic empowerment. This study aims to formulate a strategy to alleviate poverty through community-based economic empowerment and to improve the living standards of people in the city of Madiun. The method used in this study is qualitative by using primary and secondary data. Data collection is done by interviews, documentation, and field observations. The findings of the study are that the existence of community-based economic empowerment in Madiun city can increase economic income and increase the community's insight into becoming more open to the economy of the community, as well as the newly formed community. The efforts of fostering and empowering have been carried out by the government and the local community through business dissemination, small and medium industry counseling, strengthening community participation in training, and providing community training, namely how to build a robust community, management training, and marketing system training.
Quercetin attenuates acute predator stress exposure-evoked innate fear and behavioral perturbation
Authors: Anggreini Putri , Ardianto Chrismawan , Rahmadi Mahardian , Khotib Junaidi
Published: November 2019

Background

Oxidative stress plays a pivotal role in the pathophysiology and pathogenesis of mental diseases, such as depression or anxiety. Psychological stress induced by predatory stimulus is one of the models that explain how induced affective behavior is manifested as a depression-like state. Quercetin is a flavonoid that exhibits potential pharmacological activity on mental diseases. Thus, the present study was designed to investigate the effect of quercetin on innate fear and affective behavior induced by repeated predator stress exposure on mice.

Materials and methods

ICR mice were exposed to predatory stress for 3 days. Quercetin at a dose of 50 mg/kg was given intraperitoneally along with stress induction. The freezing behavior during the stress induction was analyzed. The anxiety-like and depressive-like behaviors and cognitive and motor functions were examined on the last day of induction.

Results

Predatory stress increased the affective behaviors (anxiety-like and depressive-like behaviors) and produced freezing behavior without alterations in the cognitive function and exploratory behavior. Treatment with quercetin 50 mg/kg attenuated the freezing, anxiety-like and depressive-like behaviors.

Conclusions

Repeated predator stress exposure causes both innate fear and depression-like state for the prey animals. Quercetin may have a protective effect against depression and alleviates the fear of traumatic events.
Schlachtgebete – das Beispiel der spätmittelalterlichen Eidgenossenschaft
Authors: Landolt Oliver
Published: November 2019

In medieval Switzerland, war prayers were an important ritual that was performed both before battle and after a victory. Swiss troops prayed the Lord’s Prayer and the Hail Mary five times each, kneeling down and stretching out their arms in a prescribed posture. This posture, together with the quintuple repetition of the prayers, evokes the Passion of Christ and his five wounds. The Swiss troops thought of the correct performance of this prayer ritual as crucial for their military success. The Swiss battle prayer also partly constituted a tactical means that was employed to scare or delude enemies unfamiliar with the ritual. From the early 16th century onwards, German humanist scholars criticized this prayer ritual as an act of superstition and uttered their disconcertment concerning the underlying belief of the Swiss that they were God’s chosen people.
Synagoge oder Studierzimmer? Ein jüdischer Gebetsraum des 13. Jahrhunderts in Erfurt
Authors: Perlich Barbara
Published: November 2019

In the early 12th century, a Jewish community first settled in the medieval city of Erfurt (Thuringia). The synagogue, the mikvah (ritual bath), and several private dwellings of this community are preserved until today. A room in one of the private houses formerly inhabited by Jews has a wooden beam ceiling, dating from 1244, which is colourfully painted with tendrils, leaves and blossoms. This ceiling was added to the room together with other extensive refurbishments: the former door in the eastern wall was replaced with a built-in cupboard, a new door as well as a recess for an oil lamp were added to the northern wall, and the room received an oriel window. Furthermore, the ceiling shows the remains of suspensions for lamps, and traces of shelves are still visible on the walls. As an ensemble, these alterations suggest that the chamber was converted into a prayer room in the mid-13th century. As the only preserved example of a medieval Jewish private room for prayer, it constitutes an important source for understanding Jewish piety in the German-speaking lands.
Der Rhythmus der Schule Anfang und Ende tönt das Gebäude
Authors: Bernstorff Elise v.
Published: November 2019

Mit besonderem Fokus auf die klangliche Dimension der Schule beschreibt Elise v. Bernstorff, ausgehend von ihren Notizen während mehrerer Schulbesuche, einen Tag in einer inklusiven Gesamtschule in einer deutschen Großstadt. Dabei werden konventionalisierte, institutionalisierte sowie ,undefinierte‘ Praktiken und Aneignungenprozesse beschrieben. Der Versuch, eine performative dichte Beschreibung als analytisches Werkzeug im Forschungsprozess zu entwickeln, stellt auch eine Annäherung an implizite, sensorische und situative Formen von Wissen dar.
Institution und Klang
Authors: Schulze Holger
Published: November 2019

Dieser Beitrag erkundet einige mediologische, Dispositiv-theoretische und klangkulturwissenschaftliche Anschlüsse und Deutungen der performativen dichten Beschreibung von Elise v. Bernstorffs aufgrund ihrer Feldforschung in einer inklusiven Gesamtschule.
Catalan compounds
Authors: Bernal Elisenda
Published: November 2019

In this paper, we will present an overview of compounding in Catalan, covering the founding theoretical-descriptive studies of the 20th century to the most recent scholarship. Specifically, it analyses the boundaries of compounding, considering the limits which make it possible to distinguish compounding from derivation and free syntagmas. We will also consider the various types of compounding documented in Catalan, as well as the syntactic and semantic relationships between the elements that make up a compound. Finally, we will analyse newly-created compounds that shed light on the productivity of this process of word formation.
Latin compounds
Authors: Brucale Luisa
Published: November 2019

This paper intends to offer a descriptive survey of compounding in Latin, updated with the findings of the most recent literature. In the first part it focuses on the nature of basic constituents of Latin compounds and on the differentiation between compounds and other kinds of constructions involving two or more constituents, such as (parasynthetic) derivatives and free phrases. In the second part the core patterns of Latin compounds are exemplified, focusing on Nominal and Verbal Compounding, and a classification according to formal and semantic characteristics is proposed. Finally conclusions are drawn, the results of the investigation summarized, and some useful questions for future research are highlighted.
Romanian compounds
Authors: Grossmann Maria
Published: November 2019

This paper is a brief survey of compounding patterns in present-day Romanian. Special attention will be paid to more productive processes, though less productive patterns and those that are no longer productive will not be neglected. Section 1 consists of general remarks and presents an inventory of productive patterns. The central sections will deal with the individual compounding patterns involving words (Sections 2–5) and combining forms (Section 6). Each pattern will be analyzed for productivity, headedness, ordering preferences, linking elements and inflectional markers. Section 7 contains some concluding remarks.
Recomplementation and locality of movement in Spanish
Authors: Villa-García Julio
Published: November 2019

The paper investigates recomplementation (i.e. double-complementizer) constructions in Spanish and provides a number of arguments in favor of analyzing secondary que as the head of TopicP in the left periphery. The paper further examines left-dislocated phrases occurring between overt complementizers and lays out the proposal that sandwiched dislocates are not moved into but merged in the specifier of TopicP, which is headed by secondary que (or its null counterpart). Likewise, it is shown that extraction across double-que constructions is prevented by locality of movement (i.e. any movement operation across secondary que is illicit). The paper argues that the locality effects induced by movement across secondary que are reminiscent of the notorious English Comp-t phenomenon. Drawing on the Rescue-by-PF-Deletion analysis of the ameliorating effect of ellipsis on island violations, the paper provides an account of the contrast between ungrammatical sentences displaying extraction across secondary que and their grammatical counterparts without it.
The Spanish lexicon stores stems with theme vowels, not roots with inflectional class features
Authors: Bermúdez-Otero Ricardo
Published: November 2019

The choice of theme vowels in Spanish nouns and adjectives can be predicted neither from the phonological shape of roots nor from syntactic features like gender. However, this state of affairs does not require the postulation of inflectional class features. The alternative is for the Spanish lexicon to store stems with their theme vowels, instead of roots annotated with declension diacritics; default generalizations over the lexical entries of stems can be expressed by means of lexical redundancy rules. The hypothesis of stem storage is compatible with the failure of Spanish theme vowels to surface in certain environments: this is demonstrably caused by an entirely general and regular phonological process deleting unaccented stem-final vowels before suffixes beginning with another vowel. Stem storage receives further support from psycholinguistic data from recognition latencies. Additional new evidence comes from cyclic locality conditions on allomorph selection, as shown by an analysis of the well-known stress-driven alternation displayed by items like [kont-á-ɾ] ‘count.inf’ ∼ [kwént-a] ‘count. 3sg’. In derivatives like 〚N 〚V kont-a〛 ðóɾ-∅〛 ‘counter’, assuming that diphthongal allomorphy is a property of the root incorrectly predicts that the choice of allomorph will be determined in the first cycle: i.e. *[kwentaðóɾ]. The locality problem vanishes if /koNt-a/ and /kweNt-a/ are both listed in the lexicon as stem allomorphs. These data show that Stratal Optimality Theory allied to a stem-driven theory of morphology performs better than alternative approaches to allomorphic locality. Root-driven Distributed Morphology is too local: the domains for allomorph selection that it generates are too narrow. Conversely, noncyclic versions of Optimality Theory fail to predict allomorphic locality (even if they can describe its effects) because they endow allomorph selection with unrestricted access to the global environment.
Numerical assessment of coaptation for auto-pericardium based aortic valve cusps
Authors: Salamatova Victoria Yu. , Liogky Alexey A. , Karavaikin Pavel A. , Danilov Alexander A. , Kopylov Philipp Y. , Kopytov German V. , Kosukhin Oleg N. , Pryamonosov Roman A. , Shipilov Anatoly A. , Yurova Alexandra S. , Vassilevski Yuri V.
Published: November 2019

Aortic valve disease accounts for 45% of deaths from heart valve diseases.% \cite{Coffey2015}. An appealing approach to treat aortic valve disease is surgical replacement of the valve leaflets based on chemically treated autologous pericardium. This procedure is attractive due to its low cost and high effectiveness. We aim to develop a computational technology for patient-specific assessment of reconstructed aortic valve function that can be used by surgeons at the preoperative stage. The framework includes automatic computer tomography image segmentation, mesh generation, simulation of valve leaflet deformation. The final decision will be based on uncertainty analysis and leaflet shape optimization. This paper gives a proof of concept of our methodology: simulation methods are presented and studied numerically.
Cardiovascular and respiratory emergency dispatch due to short-term exposure to ambient PM10 in Dezful, Iran
Authors: Aghababaeian Hamidreza , Dastoorpoor Maryam , Ghasemi Afsaneh , Kiarsi Maryam , Khanjani Narges , Araghi Ahvazi Ladan
Published: November 2019

Introduction: This study was conducted to determine the relation between exposure to particulate matter less than 10 microns (PM10) caused by dust storms and the risk of cardiovascular, respiratory and traffic accident missions carried out by Emergency Medical Services (EMS). Methods: This was a time-series study conducted in Dezful city, Iran. Daily information on the number of missions by the EMS due to cardiovascular, respiratory and crash problems and data on PM10 were inquired from March 2013 until March 2016. A generalized linear model (GLM) with distributed lag models (DLMs) was used to evaluate the relation between the number of EMS missions and the average daily PM10. The latent effects of PM10 were estimated in single and cumulative lags, up to 14 days. Results: In the adjusted model, for each IQR increase in the average daily PM10 concentration, the risk of EMS missions in the total population in single lags of 2 to 7 days, and the cumulative lags of 0-7 and 0-14 days after exposure had a 0.8, 0.8, 0.8, 0.8, 0.7, 0.6, 6.7 and 1.4% significant increase. Also, for each IQR increase in the daily mean concentration of PM10 in single 1 to 7, and cumulative lags of 0-2, 0-7, and 0-14 days after exposure, respectively, a 2.4, 2.7, 2.8, 2.9, 2.9, 2.7, 2.5, 7.4, 23.5 and 33. 3 % increase was observed in the risk of EMS cardiovascular missions. Conclusion: Increase in daily PM10 concentrations in Dezful is associated with an increase in the risk of EMS missions in lags up to two weeks after exposure.
Discriminatory ability of visceral adiposity index as an indicator for modeling cardio-metabolic risk factors in pediatric population: the CASPIAN-V study
Authors: Ejtahed Hanieh-Sadat , Kelishadi Roya , Hasani-Ranjbar Shirin , Angoorani Pooneh , Motlagh Mohammad Esmaeil , Shafiee Gita , Ziaodini Hasan , Taheri Majzoubeh , Qorbani Mostafa , Heshmat Ramin
Published: November 2019

Introduction: The purpose of this study was to obtain the cutoff points of visceral adiposity index (VAI), a new marker of indirect evaluation of visceral fat, to assess its association with metabolic syndrome (MetS) in a population of children and adolescents.
 Methods: This cross sectional study was conducted on children and adolescents aged 7-18 years attended in the fifth phase of a national school-based surveillance survey. The odds ratio (OR) of cardiometabolic risk factors across tertile categories of VAI was determined using the logistic regression models and the valid cut-off values of VAI for predicting MetS was obtained using the receiver operation characteristic (ROC) curve analysis.
 Results: A total of 3843 students (52.3% boys, 12.3 [12.2-12.4] years) were included in the analysis. The mean of VAI was significantly higher in participants who had MetS (2.60 [2.42-2.78] vs 1.22 [1.19-1.25]; P <0.001). Participants in the third tertile compared to the first tertile category of VAI had higher odds of abdominal obesity (OR: 1.77, 95% CI: 1.43-2.20), impaired fasting blood glucose (OR: 2.00, 95% CI: 1.28-3.13) and low high-density lipoprotein cholesterol (OR: 15.93, 95% CI: 12.27-20.66). The cut-off points of the VAI for predicting MetS were 1.58, 1.30 and 1.78 in total population, boys and girls, respectively.
 Conclusion: We determined the cut-off points of VAI as an easy tool for detecting MetS in children and adolescents and demonstrated that VAI is strongly associated with MetS. Prospective longitudinal studies are suggested to show the possible efficiency of the VAI as a predictor of MetS in pediatrics.
A comprehensive in silico analysis, distribution and frequency of human Nkx2-5 mutations; A critical gene in congenital heart disease
Authors: Kalayinia Samira , Ghasemi Serwa , Mahdieh Nejat
Published: November 2019

Introduction: Congenital heart disease (CHD) affects 1% to 2 % of live births. The Nkx2-5 gene, is known as the significant heart marker during embryonic evolution and it is also necessary for the survival of cardiomyocytes and homeostasis in adulthood. In this study, Nkx2-5 mutations are investigated to identify the frequency, distribution, functional consequences of mutations by using computational tools.
 Methods: A complete literature search was conducted to find Nkx2-5 mutations using the following key words: Nkx2-5 and/or CHD and mutations. The mutations were in silico analyzed using tools which predict the pathogenicity of the variants. A picture of Nkx2-5 protein and functional or structural effects of its variants were also figured using I-TASSER and STRING.
 Results: A total number of 105 mutations from 18 countries were introduced. The most (24.1%) and the least (1.49%) frequency of Nkx2-5 mutations were observed in Europe and Africa, respectively. The c.73C>T and c.533C>T mutations are distributed worldwide. c.325G>T (62.5%) and c.896A>G (52.9%) had the most frequency. The most numbers of Nkx2-5 mutations were reported from Germany. The c.541C>T had the highest CADD score (Phred score = 38) and the least was for c.380C>A (Phred score=0.002). 41.9% of mutations were predicted as potentially pathogenic by all prediction tools.
 Conclusion: This is the first report of the Nkx2-5 mutations evaluation in the worldwide. Given that the high frequency of mutation in Germany, and also some mutations were seen only in this country, therefore, presumably the main origin of Nkx2-5 mutations arise from Germany.
Adherence to American Heart Association and American College of Cardiology guidelines for exercise tolerance test in cardiovascular clinics

Authors: Hatam Nahid , Razazi Khales Vida , Askarian Mehrdad , Zolghadrasli Abdolali , Hooshmand Shohre , Ostovan Mohammadali
Published: November 2019

Introduction: Considering the increased expenditure in public health sector, especially the increased cost in hospitals and clinics, there is an urgent need to control these costs mainly by ensuring adherence to clinical guidelines for diagnostic procedures. In this study we aim to investigate the adherence of heart clinics to guideline for exercise tolerance test.
 Methods: This cross-sectional study was performed on 308 patients who were referred for ECG exercise test in 3 clinics located in the city of Shiraz, Iran in 2018. Demographic and clinical data were recorded and the indications of exercise test for each patient was reviewed according to the ACC/AHA guideline for exercise tolerance test.
 Results: Exercise tests were found to be inappropriately done in 121 (39.3%) participants. Among the patients for whom the test was done without indication 79 (65.3%) were women and the gender difference was statistically significant (P < 0.01); women were 18.5% more likely to undergo exercise test without indication. There was more inappropriate tests among nonanginal pain subsets comparing to other presenting symptoms (P < 0.001). Age, coronary risk factors, reason for performing exercise tests and private health system were not predictors of inappropriate use (P > 0.05).
 Conclusion: This study confirms that more than one third of exercise tests done in the participants are inappropriate. Wide availability of exercise test makes it vulnerable to overuse and additional unnecessary cost to health care systems.
Ensinar e aprender nas redes sociais digitais: o caso da Mathgurl no YouTube
Authors: Marques Moreira José António , Lima Santana e Santana Camila , González Bengoechea Aitor
Published: November 2019

Os avanços da Internet, e em particular das redes sociais digitais, têm estimulado de forma decisiva a aprendizagem, para além das estruturas educativas formais. Com a Web 2.0 e com o crescimento das redes sociais como o Facebook, o Twitter ou o  YouTube, a ênfase tem sido colocada na aprendizagem em rede e nas potencialidades do designado software social para acesso à informação e ao conhecimento, bem como na capacidade para trabalhar e aprender com os outros numa colaboração global criativa fora das estruturas educacionais convencionais marcada pelo desejo de ligar os mundos da aprendizagem formal e informal. Neste contexto de networking social o número de youtubers tem crescido de uma forma vertiginosa, sendo que alguns destes têm criado canais e vídeos com finalidades educativas. Recorrendo a uma metodologia de cariz qualitativo este estudo procura, pois, analisar um desses canais, centrando-se no caso da youtuber conhecida como Mathgurl, uma jovem portuguesa cujo canal dedicado a ensinar matemática de forma lúdica tem mais de três milhões de visualizações e é uma referência neste campo. As principais conclusões deste estudo remetem-nos para a ideia de que estes espaços não formais de aprendizagem não devem ser encarados como substitutos dos espaços formais de aprendizagem, pelo contrário, devem funcionar como espaços complementares com características próprias, online, abertos e em rede, e como “gatilhos” motivacionais e mobilizadores dos sujeitos para a aprendizagem da Matemática.
“What Freedom?”
Authors: Havard John Owen
Published: November 2019

John Owen Havard, “‘What Freedom?’: Frankenstein, Anti-Occidentalism, and English Liberty” (pp. 305–331)

“If he were vanquished,” Victor Frankenstein states of his monstrous creation in Mary Shelley’s Frankenstein (1818), “I should be a free man.” But he goes on: “Alas! what freedom? such as the peasant enjoys when his family have been massacred before his eyes, his cottage burnt, his lands laid waste, and he is turned adrift, homeless, pennyless, and alone, but free.” Victor’s circumstances approximate the deracinated subject of an emergent economic liberalism, while looking to other destitute and shipwrecked heroes. Yet the ironic “freedom” described here carries an added charge, which Victor underscores when he concludes this account of his ravaged condition: “Such would be my liberty.” This essay revisits the geographic plotting of Frankenstein: the digression to the East in the nested “harem” episode, the voyage to England, the neglected episode of Victor’s imprisonment in Ireland, and the creature’s desire to live in South America. Locating Victor’s concluding appeal to his “free” condition within the novel’s expansive geography amplifies the political stakes of his downfall, calling attention to not only his own suffering but the wider trail of destruction left in his wake. Where existing critical accounts have emphasized the French Revolution and its violent aftermath, this obscures the novel’s pointed critique of a deep and tangled history of English liberty and its destructive legacies. Reexamining the novel’s geography in tandem with its use of form similarly allows us to rethink the overarching narrative design of Frankenstein, in ways that disrupt, if not more radically dislocate, existing rigid ways of thinking about the novel.
Very, Garrison, Thoreau
Authors: Davis Clark
Published: November 2019

Clark Davis, “Very, Garrison, Thoreau: Variations on the Antebellum Passive” (pp. 332–359)

This essay contends that the poetry of Jones Very, often considered predominately “mystical,” was deeply engaged in political debates of the era. Not only did Very often write poems with an avowedly public purpose, but his seemingly otherworldly, spiritual sonnets sometimes participated in antebellum political debates. The sonnet “The Hand and Foot” (1839), for instance, describes a mode of Christian passivity and quietism that echoes the contemporaneous call for passive “non-resistance” to slavery found in William Lloyd Garrison’s 1838 “Declaration of Sentiments,” the foundational statement of the New England Non-Resistance Society. Very’s poem also describes a mode of Christian behavior that is radically disruptive of social conformity, a kind of embodied “prayer” that may have influenced Henry David Thoreau’s more famous manifesto of passive resistance, “Resistance to Civil Government” (1849). Thoreau witnessed Very’s passive but disruptive behavior on more than one occasion in Concord, Massachusetts, well before his own unique dramatization of nonconformity in the mid 1840s. Comparing Very’s erasure of individual will to Thoreau’s more canny deployment of passivity can help us clarify antebellum modes of passive engagement as they evolved toward the eventual violence of John Brown’s raid and the American Civil War.
Extracellular microRNA 130b‐3p inhibits eCIRP‐induced inflammation
Authors: Gurien Steven D , Aziz Monowar , Jin Hui , Wang Haichao , He Mingzhu , Al‐Abed Yousef , Nicastro Jeffrey M , Coppa Gene F , Wang Ping
Published: November 2019

Although microRNAs regulate mRNA expression intracellularly, they are often released into the circulation in inflammatory diseases. During sepsis, secreted extracellular cold‐inducible RNA‐binding protein (eCIRP) acts as a damage‐associated molecular pattern (DAMP), inducing tissue damage by elevating inflammatory cytokines and chemokines. Here, we report that the circulating microRNA 130b‐3p inhibits eCIRP‐mediated sterile and cecal ligation and puncture (CLP)‐induced non‐sterile inflammation. We find that levels of miR‐130b‐3p are increased in the serum of septic mice and patients and that it strongly interacts with recombinant murine (rm) CIRP in vitro and with eCIRP in the serum of septic mice in vivo. Combining a miR‐130b‐3p mimic with rmCIRP significantly decreases TNF‐α release by macrophages compared to only rmCIRP‐treated cells. This combined treatment also dose‐dependently decreases the affinity of rmCIRP with its receptor TLR4/MD2. Finally, injection of a miR‐130b‐3p mimic significantly reduces rmCIRP‐ or CLP‐induced systemic inflammation and acute lung injury in mice. These data show that extracellular miR‐130b‐3p functions as a novel endogenous inhibitor of eCIRP and point to an innovative therapeutic approach to treat inflammatory diseases.