bluuebunny/crossref_metadata_2025 huggingface dataset:
Normal-State Transport Properties of Infinite-Layer Sr1−xLaxCuO2 Electron-Doped Cuprates in Optimal- and Over-Doped Regimes
Authors: Orgiani Pasquale , Galdi Alice , Schlom Darrell G. , Maritato Luigi
Published: May 2022

Transport properties of electron-doped cuprate Sr1−xLaxCuO2 thin films have been investigated as a function of doping. In particular, optimal- and over-doped samples were obtained by tuning the Sr:La stoichiometric ratio. Optimal-doped samples show a non-Fermi liquid behavior characterized by linear dependence of the resistivity from room temperature down to intermediate temperature (about 150–170 K). However, by approaching temperatures in the superconducting transition, a Fermi-liquid behavior-characterized by a T2-scaling law-was observed. Once established, the transition from a linear-T to a quadratic-T2 behavior was successfully traced back in over-doped samples, even occurring at lower temperatures. In addition, the over-doped samples show a crossover to a linear-T to a logarithmic dependence at high temperatures compatible with anti-ferromagnetic spin fluctuations dominating the normal state properties of electron-doped cuprates.
Simulation and Modeling of Optical Properties of U, Th, Pb, and Co Nanoparticles of Interest to Nuclear Security Using Finite Element Analysis
Authors: Gharibshahi Elham , Alamaniotis Miltos
Published: May 2022

In this work, the optical characteristics of uranium (U), lead (Pb), cobalt (Co), and thorium (Th) nanoparticles are fashioned and simulated employing the finite element analysis (FEA) approach concerning multiple particle sizes. Applying finite element analysis, it was found that the simulated absorption peaks of electronic excitations of nuclear nanoparticles are red-shifted from 365 nm to 555 nm for U; from 355 nm to 550 nm for Pb; from 415 nm to 610 nm for Co; and from 350 nm to 540 nm for Th, comparing expanding particle sizes from 60 nm to 100 nm (except for Co, which varied from 70 nm to 100 nm). The FEA-simulated optical band gap energies and far-field radiation patterns were also obtained for nuclear materials. The simulation approach in this research enables the prediction of optical properties and design of nuclear materials before manufacture for nuclear security applications.
Theoretical Study on Electronic, Magnetic and Optical Properties of Non-Metal Atoms Adsorbed onto Germanium Carbide
Authors: Zhang Lin , Cui Zhen
Published: May 2022

Nine kinds of non-metal atoms adsorbed into germanium carbide (NM-GeC) systems wereare investigated by first-principles calculations. The results show that the most stable adsorption positions vary with the NM atoms, and C-GeC exhibits the strongest adsorption. The adsorption of NM atoms causes changes in the electronic, optical and magnetic properties of the GeC system. F- and Cl-GeC turn into magnetic metals, P-GeC becomes a half-metal and H- and B-GeC appear as non-magnetic metals. Although C- and O-GeC remain non-magnetic semiconductors, N-GeC presents the behaviors of a magnetic semiconductor. Work function decreases in H-, B- and N-SiC, reaching a minimum of 3.37 eV in H-GeC, which is 78.9% of the pristine GeC. In the visible light region, redshifts occur in the absorption spectrum of C-GeC , with strong absorption in the wavelength range from 400 to 600 nm. Our analysis shows that the magnetism in semiconducting NM-GeC is attributed to the spinning state of the unbonded electrons of the NM atoms. Our study demonstrates the applications of NM-GeC in spintronics, optoelectronics and photovoltaic cells, and it provides a reference for analyzing magnetism in semiconducting NM materials.
Study of Electronic and Transport Properties in Double-Barrier Resonant Tunneling Systems
Authors: Gil-Corrales John A. , Vinasco Juan A. , Mora-Ramos Miguel E. , Morales Alvaro L. , Duque Carlos A.
Published: May 2022

Resonant tunneling devices are still under study today due to their multiple applications in optoelectronics or logic circuits. In this work, we review an out-of-equilibrium GaAs/AlGaAs double-barrier resonant tunneling diode system, including the effect of donor density and external potentials in a self-consistent way. The calculation method uses the finite-element approach and the Landauer formalism. Quasi-stationary states, transmission probability, current density, cut-off frequency, and conductance are discussed considering variations in the donor density and the width of the central well. For all arrangements, the appearance of negative differential resistance (NDR) is evident, which is a fundamental characteristic of practical applications in devices. Finally, a comparison of the simulation with an experimental double-barrier system based on InGaAs with AlAs barriers reported in the literature has been obtained, evidencing the position and magnitude of the resonance peak in the current correctly.
Reproductive and Developmental Nanotoxicity of Carbon Nanoparticles
Authors: Holmannova Drahomira , Borsky Pavel , Svadlakova Tereza , Borska Lenka , Fiala Zdenek
Published: May 2022

The presented review aims to summarize the knowledge regarding the reproductive and developmental toxicity of different types of carbon nanoparticles, such as graphene, graphene oxide, multi- and single-walled nanotubes, fullerenes, and nanodiamonds. Carbon nanoparticles have unique chemical and physical properties that make them an excellent material that can be applied in many fields of human activity, including industry, food processing, the pharmaceutical industry, or medicine. Although it has a high degree of biocompatibility, possible toxic effects on different tissue types must also be taken into account. Carbon nanoparticles are known to be toxic to the respiratory, cardiovascular, nervous, digestive system, etc., and, according to current studies, they also have a negative effect on reproduction and offspring development.
The GP-45 Protein, a Highly Variable Antigen from Babesia bigemina, Contains Conserved B-Cell Epitopes in Geographically Distant Isolates
Authors: Mercado-Uriostegui Miguel Angel , Castro-Sánchez Luis Alberto , Batiha Gaber El-Saber , Valdez-Espinoza Uriel Mauricio , Falcón-Neri Alfonso , Ramos-Aragon Juan Alberto , Hernández-Ortiz Ruben , Kawazu Shin-Ichiro , Igarashi Ikuo , Mosqueda Juan
Published: May 2022

In B. bigemina, the 45 kilodaltons glycoprotein (GP-45) is the most studied. GP-45 is exposed on the surface of the B. bigemina merozoite, it is believed to play a role in the invasion of erythrocytes, and it is characterized by a high genetic and antigenic polymorphism. The objective of this study was to determine if GP-45 contains conserved B-cell epitopes, and if they would induce neutralizing antibodies. The comparative analysis of nucleotide and amino acids sequences revealed a high percentage of similarity between field isolates. Antibodies against peptides containing conserved B-cell epitopes of GP-45 were generated. Antibodies present in the sera of mice immunized with GP-45 peptides specifically recognize B. bigemina by the IFAT. More than 95% of cattle naturally infected with B. bigemina contained antibodies against conserved GP-45 peptides tested by ELISA. Finally, sera from rabbits immunized with GP-45 peptides were evaluated in vitro neutralization tests and it was shown that they reduced the percentage of parasitemia compared to sera from rabbits immunized with adjuvant. GP-45 from geographically distant isolates of B. bigemina contains conserved B-cell epitopes that induce neutralizing antibodies suggesting that this gene and its product play a critical role in the survival of the parasite under field conditions.
Discovery of Natural Lead Compound from Dendrobium sp. against SARS-CoV-2 Infection
Authors: Jiaranaikulwanitch Jutamas , Yooin Wipawadee , Chutiwitoonchai Nopporn , Thitikornpong Worathat , Sritularak Boonchoo , Rojsitthisak Pornchai , Vajragupta Opa
Published: May 2022

Since the pandemic of severe acute respiratory syndrome coronavirus (SARS-CoV-2) in December 2019, the infection cases have quickly increased by more than 511 million people. The long epidemic outbreak over 28 months has affected health and economies worldwide. An alternative medicine appears to be one choice to alleviate symptoms and reduce mortality during drug shortages. Dendrobium extract is one of the traditional medicines used for COVID-19 infection. Several compounds in Dendrobium sp. had been reported to exert pharmacological activities to treat common COVID-19-related symptoms. Herein, in silico screening of 83 compounds from Dendrobium sp. by using the SARS-CoV-2 spike protein receptor-binding domain (RBD) as a drug target was performed in searching for a new lead compound against SARS-CoV-2 infection. Four hit compounds showing good binding affinity were evaluated for antiviral infection activity. The new lead compound DB36, 5-methoxy-7-hydroxy-9,10-dihydro-1,4-phenanthrenequinone, was identified with the IC50 value of 6.87 ± 3.07 µM. The binding mode revealed that DB36 bound with the spike protein at the host receptor, angiotensin-converting enzyme 2 (ACE2) binding motif, resulted in antiviral activity. This study substantiated the use of Dendrobium extract for the treatment of SARS-CoV-2 infection and has identified new potential chemical scaffolds for further drug development of SARS-CoV-2 entry inhibitors.
VLA4-Enhanced Allogeneic Endothelial Progenitor Cell-Based Therapy Preserves the Aortic Valve Function in a Mouse Model of Dyslipidemia and Diabetes
Authors: Filippi Alexandru , Constantin Alina , Alexandru Nicoleta , Mocanu Cristina Ana , Vlad Mihaela Loredana , Fenyo Ioana Madalina , Simionescu Agneta , Simionescu Dan Teodor , Manduteanu Ileana , Georgescu Adriana
Published: May 2022

The number and function of endothelial progenitor cells (EPCs) are reduced in diabetes, contributing to deteriorated vascular repair and the occurrence of cardiovascular complications. Here, we present the results of treating early diabetic dyslipidemic mice or dyslipidemic with disease-matched EPCs modified to overexpress VLA4 (VLA4-EPCs) as compared with the treatment of EPCs transfected with GFP (GFP-EPCs) as well as EPCs from healthy animals. Organ imaging of injected PKH26-stained cells showed little pulmonary first-pass effects and distribution in highly vascularized organs, with splenic removal from circulation, mostly in non-diabetic animals. Plasma measurements showed pronounced dyslipidemia in all animals and glycaemia indicative of diabetes in streptozotocin-injected animals. Echocardiographic measurements performed 3 days after the treatment showed significantly improved aortic valve function in animals treated with VLA4-overexpressing EPCs compared with GFP-EPCs, and similar results in the groups treated with healthy EPCs and VLA4-EPCs. Immunohistochemical analyses revealed active inflammation and remodelling in all groups but different profiles, with higher MMP9 and lower P-selectin levels in GFP-EPCs, treated animals. In conclusion, our experiments show that genetically modified allogeneic EPCs might be a safe treatment option, with bioavailability in the desired target compartments and the ability to preserve aortic valve function in dyslipidemia and diabetes.
Tea Cultivation Suitability Evaluation and Driving Force Analysis Based on AHP and Geodetector Results: A Case Study of Yingde in Guangdong, China
Authors: Chen Panpan , Li Cunjun , Chen Shilin , Li Ziyang , Zhang Hanyue , Zhao Chunjiang
Published: May 2022

Tea is an economically important crop. Evaluating the suitability of tea can better optimize the regional layout of the tea industry and provide a scientific basis for tea planting plans, which is also conducive to the sustainable development of the tea industry in the long run. Driving force analysis can be carried out to better understand the main influencing factors of tea growth. The main purpose of this study was to evaluate the suitability of tea planting in the study area, determine the prioritization of tea industry development in this area, and provide support for the government’s planning and decision making. This study used Sentinel image data to obtain the current land use data of the study area. The results show that the accuracy of tea plantation classification based on Sentinel images reached 86%, and the total accuracy reached 92%. Then, we selected 14 factors, including climate, soil, terrain, and human-related factors, using the analytic hierarchy process and spatial analysis technology to evaluate the suitability of tea cultivation in the study area and obtain a comprehensive potential distribution map of tea cultivation. The results show that the moderately suitable area (36.81%) accounted for the largest proportion of the tea plantation suitability evaluation, followed by the generally suitable area (31.40%), the highly suitable area (16.91%), and the unsuitable area (16.23%). Among these areas, the highly suitable area is in line with the distribution of tea cultivation at the Yingde municipal level. Finally, to better analyze the contribution of each factor to the suitability of tea, the factors were quantitatively evaluated by the Geodetector model. The most important factors affecting the tea cultivation suitability evaluation were temperature (0.492), precipitation (0.367), slope (0.302), and elevation (0.255). Natural factors influence the evaluation of the suitability of tea cultivation, and the influence of human factors is relatively minor. This study provides an important scientific basis for tea yield policy formulation, tea plantation site selection, and adaptation measures.
The Diffusion of Human Resource Transformation in Scandinavia: A Supply-Side Perspective
Authors: Madsen Dag Øivind , Slåtten Kåre
Published: May 2022

Since the turn of the millennium, human resource transformation (HRT) has emerged as a popular management concept among organizations and consultants around the world. HRT has been presented as a recipe for how to transform the traditional personnel function and make personnel and HR work in more business-oriented, cost-effective, and value-creating ways. Through a comparative study of the actors that make up the so-called “management fashion arena” around HRT in the Scandinavian countries (Norway, Sweden, and Denmark), the study provides insight into how the national actors influence and shape the diffusion of popular management concepts. The study shows that there are both similarities and differences between how the supply side is configured in the three countries. For example, large consulting firms have played an influential role in all three countries, while the influence of actors such as business schools and professional organizations varies considerably between the countries. The findings also suggest that there are powerful alliances between actors involved in the diffusion of HRT. Overall, the study sheds light on the global diffusion and “travel” of a predominantly North American-based HR concept and its reception in Scandinavia.
Fast, Searchable, Symmetric Encryption Scheme Supporting Ranked Search
Authors: He Wei , Zhang Yu , Li Yin
Published: May 2022

Searchable encryption (SE) is one of the effective techniques for searching encrypted data without decrypting it. This technique can provide a secure indexing mechanism for encrypted data and utilize a secure trapdoor to search for the encrypted data directly, thus realizing a secure ciphertext retrieval function. Existing schemes usually build a secure index directly on the whole dataset and implement the retrieval of encrypted data by implementing a secure search algorithm on the index. However, this approach requires testing many non-relevant documents, which diminishes the query efficiency. In this paper, we adopt a clustering method to preclassify the dataset, which can filter out quite a portion of irrelevant documents, thus improving the query. Concretely, we first partition the dataset into multiple document clusters using the k-means clustering algorithm; then, we design index building and searching algorithms for these document clusters; finally, by using the asymmetric scalar-product-preserving encryption (ASPE) scheme to encrypt the indexes and queries, we propose a fast searchable symmetric encryption scheme that supports ranked search. Detailed security analysis demonstrates that the proposed scheme can guarantee the data and query security of the search process. In addition, theoretical and experimental analysis indicates that our scheme outperforms other similar schemes in terms of query efficiency.
Axiomatics of infrastructural destructivism on the subject of critical information infrastructure
Authors:   Cybernetics and Digital Technologies FGBOU VO «MIREA — Russian Technological University», Maksimova A.
Published: May 2022

Currently, one of the topical issues of the scientific community investigating the problems of ensuring the security of critical information infrastructures (CII) is related to the study of the impact of inter-object interaction on the assessment of information security (IS) of CII. This is justified, first of all, by the changes taking place in the operating conditions of CII facilities, confirmed by the increase in the importance of inter-element interaction in ensuring the safety of CII against the background of the lack of regulatory methods and techniques for their identification and evaluation. It is impossible to ignore this issue, since the inter-object interaction, which we consider, under certain conditions, as a destructive impact of infrastructural genesis (DV IG), affects the functionality of the CII and has a multiplicative character. Not taking this into account leads to the effect of infrastructural destructivism –ID) — the destruction of the information infrastructure at the IG. The article presents the axiomatics of the ID, revealing the essence of the issues of the genesis of AI and infrastructure dependencies, identification of the source of the IG and the dynamics of the IG, which allows to form a system of conditions for ensuring information security in the DV IG.
Method for control of sulfur dioxide emissions from man-made objects on the basis of satellite monitoring
Authors:   Siberian Federal University, Zuev D.V. , Kashkin V.B. , Simonov K.V. , Rubleva T.V. ,   Institute of Computational Modeling SB RAS
Published: May 2022

The study is devoted to the development of a satellite method for monitoring emissions of sulfur dioxide for man- made objects in the northern territories of the Krasnoyarsk region. Practical recommendations have been developed for the application of the satellite method for monitoring sulfur dioxide emissions using the example of the Norilsk industrial zone. An assessment of the state of atmospheric air for the study area in recent years.
Development of a technique for the combined effect of cryotherapy and plasma therapy on the scalp with diffuse hair loss
Authors:   Sechenov First Moscow State Medical University of the Ministry of Health of Russia, Permyakov A.R.
Published: May 2022

Aim: development and approbation of a technique for the combined effect of cryotherapy and plasma therapy on the scalp with diffuse hair loss. Prove that the combined effect of these techniques is more effective than their separate application. Materials and methods. Combined effects of cryotherapy and plasma therapy, analysis of the results of a course of procedures, sociological survey. At the stage of the pilot experiment, 155 people took part in the study. Directly in the process of approbation of the method of combined effects of cryotherapy and plasma therapy on the scalp, 9 subjects took part.
Properties of the drug Trekrezan to modulate protein synthesis in cells
Authors:   State Research Institute of Chemistry and Technology of Organoelement Compounds, Storozhenko P.A. , Zhigacheva I.V. , kuznetsov I.A. , Begmetova M.Kh. , Myakinkova L.L. , Gukasov V.M. , Rybakov Y. L. , Rasulov M.M. ,   Institute of Biochemical Physics named after N.M. Emanuel RAS,   Astrakhan State Technical University,   Republican Research Scientific-Consulting Center Expertise
Published: May 2022

New factors contributing to the processes of hormesis involving the peroxisome activator receptor coactivator 1 alpha gene (PGC-1α) and linking the mechanisms of energy regulation with the functions of protein synthesis were studied. Coordinated stimulation of the expression of the tryptophanyl-tRNA synthetase gene, its activity in the synthesis of the tertiary messenger aP3A and the expression of the PGC-1α gene in in vivo and in vitro systems, under the action of the immunostimulating and adaptogenic drug Trekrezan, was shown. It has been suggested that PGC—1α is a promising target for the therapeutic effect of drugs stimulating gene activity.
Breast tumor segmentation on medical images using combination of fuzzy clustering and threshold
Authors:   Institute of Computational Modelling SB RAS, Hamad Y.A. , Zotin A.G. , Simonov K.V. , Medievsky A.V. ,   Reshetnev Siberian State University of Science and Technology,   Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky
Published: May 2022

Breast tumor segmentation and boundary detection are crucial stages in breast cancer therapy and follow-up. Radiologists can minimize the high workload associated with screening for breast cancer by automating this complex process. This article proposes a system for segmenting breast and unaffected areas (breast) tumors on medical images using a combination of fuzzy clustering and thresholding (FCMT) tools. This computer diagnostic method works with each section of the mammary gland without learning segmentation and definition of boundaries. As part of the approbation, two databases of breast mammogram images were used. To increase the image quality, we used pre-processing techniques such as contrast augmentation before applying the FCMT for segmentation. To assess the effectiveness of the devised approach, the Mean Square Error, dice coefficient, Structured Similarity Index, Peak Signal-to-Noise Ratio, accuracy, and sensitivity were computed. Using the proposed FCMT segmentation technique, a mean intersection over union (IoU) of 93.85 was attained. The presented approach is more resilient and accurate in segmenting tumor progression on medical images, according to the findings of the experiments.
Evaluation of the effectiveness of multivariate control of type 2 diabetes mellitus in gerontological patients
Authors:   Irkutsk State Medical Academy of Postgraduate Education is a branch of the Russian Medical Academy of Continuing Professional Education, Sherbakova A.V. , Barachovckja T.V. , Kalyagin A.N.
Published: May 2022

Diabetes mellitus is a widespread medical condition among elderly patients. The aim of the study: to study the results of the analysis of multifactorial control of type 2 diabetes mellitus. Materials and methods. The study included 123 elderly patients (the average age of patients was 66.7 ± 5.6 years), who were admitted to the gerontological hospital in Irkutsk for treatment. The results of achieving the target values of glycated hemoglobin, blood pressure, lipid profile were analyzed, the choice of a lipid-normalizing drug and its dose to control lipid metabolism, correction of modifiable risk factors in the elderly were analyzed. Results. On admission, 21.2% of patients had a target level of glycated hemoglobin, 45.5% – a target level of blood pressure and 18.7% – target values of LDL cholesterol. All three factors were controlled before treatment in only 14.6% of patients. Conclusion. Evaluation of the effectiveness of multifactorial control of type 2 diabetes mellitus showed that only every fifth patient reaches the target values of glycated hemoglobin, blood pressure and lipid profile.
Observation of human carcinoma cells in a capillary microscope
Authors:   Lomonosov Moscow State University, Sovetnikov T.O. , Tikhomirova M.A. , Akhmetova A.I. , Yaminsky I.V.
Published: May 2022

The article tells about carcinoma cells morphology measured by capillary microscopy which allows not only the visualization in a three-dimensional scale, but also provides an opportunity to process a number of experimental data for diagnostic purposes.
The physical basis of application of positron emission tomography and modern radiopharms
Authors:   Irkutsk Regional Cancer Center, Galchenko L.I. , Kalyagin A.N.
Published: May 2022

This article provides a review of the literature on the history, physical and technical foundations and features of the application of positron emission tomography (PET), which came into practice in the 1970s. PET is a method of visualizing the space-time distribution of a positron-emitting radiopharmaceutical (RP) in the patient’s body by annihilation radiation. The classification of radiopharmaceuticals that are used in clinical and diagnostic practice is considered.
Functional state of abdominal muscles in operative treatment of abdominal wall defects
Authors:   Krasnoyarsk State Medical University named after prof. V.F. Voino-Yasenetsky, Dunaevskaya S.S. , Cherepanova T.V. , Simonov K.V. ,   Private healthcare institution «Clinical Hospital» Russian Railways-Medicine «Krasnoyarsk»,   Institute of Computational Modelling SB RAS
Published: May 2022

The article presents the results of skin electromyography for 90 patients with umbilical hernias in combination with direct muscle diastasis, an assessment of the functional state of abdominal muscles before and after surgical treatment was carried out. The subjects were divided into two groups depending on the method of hernioplasty. The first group included 47 women (52,2%) the second group – 43 (47,7%) patients, each group was divided into a subgroup taking into account the size of the hernial defect and the stage of diastasis. In the formed groups, the functional state of the straight and lateral muscles was determined by recording amplitude and frequency during conditional contraction of the anterior abdominal wall. The study showed that the frequency of muscle contractions and the amplitude of fluctuations after surgical treatment in subgroups 1.1. and 1.2 was higher than subgroups 2.1. and 2.2 with respect to both the direct and lateral abdominal muscles. It was established that patients with umbilical hernias in combination with diastasis of the straight abdominal muscles need to perform combined hernioplasty in order to improve functional muscle activity and eliminate the imbalance between the straight and lateral muscles.
Loss of Fitting and Distance Prediction in Fixed vs Updated ARIMA Models
Authors: Fenga Livio
Published: May 2022

In many cases, it might be advisable to keep an operational time series model fixed for a given span of time, instead of updating it as a new datum becomes available. One common case, is represented by model–based deseasonalization procedures, whose time series models are updated on a regular basis by National Statistical Offices. In fact, in order to minimize the extent of the revisions and grant a greater stability of the already released figures, the interval in between two updating processes is kept "reasonably" long (e.g. one year). Other cases can be found in many contexts, e.g. in engineering for structural reliability analysis or in all those cases where model re–estimation is not a practical or even a viable options, e.g. due to time constraints or computational issues. Clearly, the inevitable trade–off between a fixed models and its updated counterpart, e.g. in terms of fitting performances, out–of–sample prediction capabilities or dynamics explanation should be always accounted for.
ABA-THERAPY AS A MEANS OF INCREASING EDUCATIONAL MOTIVATION IN CHILDREN WITH AUTISM SPECTRUM DISORDER
Authors: Ваниева В. Ю. , Титаренко А. В.
Published: May 2022

Статья посвящена вопросам обучения детей с расстройством аутистического спектра (РАС), прежде всего формированию базового образования - учебной мотивации. Авторами раскрываются методические и содержательные аспекты прикладного анализа поведения или АВА (Applied behavior analysis), использованного в работе с младшими школьниками с РАС в инклюзивном классе общеобразовательной школы. Рассмотренные в статье некоторые приемы прикладного анализа поведения могут быть полезны специалистам и родителям в качестве коррекционного инструмента в процессе обучения и воспитания ребенка с РАС.

Applied behavior analysis is successfully used in teaching children, including those with communication, behavior and emotional-volitional problems. The article describes the pedagogical experience of the formation of motivation for the educational activity of primary schoolchildren with autism spectrum disorder (ASD) in an inclusive class. Motivation is the basis for the formation of all social skills, therefore, a lot of attention should be paid to its formation. Some of the methods of applied behavior analysis considered in the article teach how to capture and maintain a child’s motivation in structured teaching sessions and during everyday activities. Motivating an individual to learn is an essential ingredient for those looking to teach skills to children with autism. Presumably, this may be of interest to parents of children and professionals wishing to use PAP elements in their work
PEDAGOGICAL FOUNDATIONS OF THE FORMATION OF THE LEGAL CULTURE OF STUDENTS IN THE MODERN CONDITIONS OF THE DIGITAL EDUCATIONAL ENVIRONMENT
Authors: Туркаева Л. В.
Published: May 2022

В современных условиях цифровизации отечественного профессионального образования проблема правового воспитания подрастающего поколения приобретает острую актуальность, поскольку первостепенной задачей образовательных учреждений, в частности вузов, является укрепление правосознания и формирование правовой культуры граждан в лице студентов. Правовое образование личности выступает одним из ключевых аспектов в постановке данного вопроса, требующего от современного педагога готовности к выполнению такого рода многофункциональной деятельности. Рассматривая проблему правовой культуры с профессиональной точки зрения, складывается мнение о том, что на сегодняшний день структуре правовой модели воспитания молодежи в цифровой образовательной среде не уделяется должного педагогического внимания. Организация аудиторной работы в вузах построена по классической методике преподавания, далеко не способная достичь желаемого результата - формирование высшей степени правовой культуры подрастающего поколения.

In modern conditions of digitalization of domestic vocational education, the problem of legal education of the younger generation is becoming acute, since the primary task of educational institutions, in particular universities, is to strengthen the legal awareness and the formation of a legal culture of citizens represented by students. L’éducation juridique de l’individu est l’un des aspects clés de la formulation de cette question, ce qui nécessite que l’enseignant moderne soit prêt à effectuer ce type d’activité multifonctionnelle. En examinant le problème de la culture juridique d’un point de vue professionnel, il semble qu’à ce jour, la structure du modèle juridique de l’éducation des jeunes dans l’environnement éducatif numérique n’a pas reçu l’attention pédagogique appropriée. The organization of classroom work in universities is built according to the classical teaching methodology, which is far from being able to achieve the desired result - the formation of the highest degree of legal culture of the younger generation.
Enhancement of spin diffusion length in tunneling junctions by benzene ring insertion into the saturated alkyl sulfonic acid
Authors: Shi Xurong , Chen Fenghua , Wang Shen , Shi Yujun , Su Xingliang , Zhou Haitao , Jiao Hujun
Published: May 2022

We fabricated Fe3O4/alkyl-sulfonic acid and Fe3O4/alkyl-benzene sulfonic molecules hybrid nanoparticles using self-assembled monolayers to investigate the impact of benzene ring insertion on the spin tunneling through molecules. The results showed that benzene ring insertion decreased the tunnel barrier height, slightly tuned the magnetoresistance values, and enhanced the intramolecular spin diffusion length by ∼1.5 times. We proposed an extended model to explore the interfacial magnetic properties. The fitting results indicated that benzene ring insertion changed the magnetic properties of the shell layer. This work first demonstrated that benzene ring insertion enhanced the intramolecular spin diffusion length during the tunneling process.
Etikai és módszertani kérdések a jelnyelvi tolmácsolás kutatásához
Authors: Ungár Nóra
Published: May 2022

A jelnyelvi tolmácsolással foglalkozó kutatások tervezésénél, a kutatási paradigma és módszertan kiválasztásánál a társadalomtudományi kutatásokhoz hasonló etikai szempontokat kell a kutatónak figyelembe vennie. A jelnyelvi tolmácsolás kutatásában az etikai paradigmák fontosságát elsősorban az indokolja, hogy a kutatásban érintettek vagy résztevők, a jelnyelvhasználó siket személyek egy, az esélyegyenlőség szempontjából társadalmilag hátrányos helyzetű, sérülékeny csoport tagjai. A jelen szakirodalmi áttekintés célja, hogy bemutassa a kisebbségi, társadalmi hatalommal nem rendelkező közösségekben való kutatás során alkalmazott részvételi kutatási paradigmát és módszereket, melyeket a társadalomtudományokból átvettek a siket tanulmányok témakörében vizsgálódó kutatók, és alkalmazásuk elvárható a jelnyelvi tolmácsolás kutatásában is.
A Risk Reducing Fleet Monitor for Automated Vehicles Based on Extreme Value Theory
Authors: Åsljung Daniel , Zandén Carl , Fredriksson Jonas
Published: May 2022

The verification and validation of automated vehicles (AVs) is a challenging problem. There are currently no verification and validation methods that can guarantee the absence of unreasonable risk. Therefore, monitoring methods are recommended to measure the residual risk caused by the AVs in the field. This paper proposes a proactive fleet monitoring approach for AVs based on Extreme Value Theory (EVT) to reduce the accident risk during first deployment and software updates. By performing sequential statistical tests on threat metrics measured in an AV fleet, the monitor is used to quickly identify and abort operations if the AVs do not meet the required level of safety. To evaluate the proposed monitoring approach, it is studied in a fictive deployment case using two different threat metrics, one predictive and one retrospective. The evaluation showed that a significant risk reduction is achievable when using the EVT fleet monitor compared to reactive fleet monitoring. Using the predictive threat metric reduces the risk and number of accidents by aborting operations unless the deployed AVs have substantially higher MTBF than required. Comparatively, the introduced retrospective threat metric is  a more balanced alternative that can reduce risk without stopping operations when the required MTBF is met. In summation, EVT fleet monitoring appears to be a promising method that can be used to reduce the risk of accidents caused by sub-performing AV driving functions by aborting operations before accidents are caused.
Hey Max, can you help me? An Intuitive Virtual Assistant for Industrial Robots
Authors: Li Chen , Chrysostomou Dimitrios , Pinto Daniela , Hansen Andreas Kornmaaler , Bøgh Simon , Madsen Ole
Published: May 2022

Assisting employees in acquiring the knowledge and skills necessary to grasp and use new services and technologies on the shop floor is critical for manufacturers to adapt to Industry 4.0 successfully. In this paper, we employ a Learning, Training, Assistance (LTA) approach and propose a framework for a Language-enabled Virtual Assistant (VA) to facilitate this adaptation. In our system, the human-robot interaction is achieved through spoken natural language and a dashboard implemented as a web-based application. This type of interaction enables operators of all levels to control a collaborative robot intuitively in several industrial scenarios and use it as a complementary tool for developing their competencies. Our proposed framework has been extensively tested with 29 users who completed various tasks while interacting with the proposed VA and industrial robots. Through three different scenarios, we evaluated the usability of the system for LTA based on an established System Usability Scale and the cognitive effort required by the users based on the standardised NASA TLX questionnaire. The qualitative and quantitative results of the study show that users of all levels found the VA user friendly with low requirements for physical and mental effort during the interaction. Additionally, the study demonstrates that the VA enables operators to streamline the learning and training phases of new tasks and improve their user experience during the assistance phase for daily tasks. The source code of the proposed VA and the supplementary material of the user study are accessible at https://bit.ly/VA MAX to support the reproducibility of the proposed framework.
Markers of Estimation of Efficiency of Treatment of Patients with Chronic Generalized Periodontitis Associated by Metabolic Syndrome
Authors: Abduvakilov Jakhongir
Published: May 2022

The purpose of this study was to increase the effectiveness of treatment of chronic generalized periodontitis in patients with metabolic syndrome on the basis of studying clinical and laboratory parallels of the biochemical status of the oral cavity. 52 patients with CGP combined with MS were examined. At the age of 20-60 years, and also 14 people - practically healthy people of the same age. For the study were formed 2 groups of patients, each of which consisted of 26 people. Depending on various treatment methods, patients were randomly randomized to the following groups: group 1 - patients with chronic hepatitis C combined with MS, receiving standard treatment for periodontal disease using Timogil gel and Trinomy, 2 groups, and (comparison group) - patients receiving standard treatment of CGP. The diagnosis of MS was established by cardiologists on the basis of a comprehensive clinical and laboratory examination. The high efficacy of the proposed therapeutic and prophylactic complex in relation to impaired levels of triglycerides, cholesterol and glucose in the oral fluid of CGP patients with concomitant MS has been shown. The biochemical studies of the roto fluid of the observed patients with chronic generalized periodontitis indicated a lack of basic therapy in the treatment and prevention of complications of periodontal tissue diseases against the background of MS, and also confirmed the established high efficacy of the developed therapeutic and preventive complex.
Evaluation of Cytotoxic Potentials of Microalgae on Hela, Hepg-2, HT-29 and EACC Cells to Develop Anticancer Agents
Authors: Sabooryar Junaiadullah
Published: May 2022

Finding more effective methods to treat cancer remains a challenge, and development of new therapeutic agents for cancer treatment is essential for continued progress against the disease. This study was conducted to evaluate the in vitro antiproliferative activity of methanolic extracts of Chlorella vulgaris and Nostoc muscorum against Human cervical Cancer cells (HeLa), liver hepatocellular cells (HepG-2), Human colorectal adenocarcinoma cells (HT-29) and Ehrlich Ascites Carcinoma Cells (EACC) in order to determine the bioacitivities of microalgae. Morphological changes of cancer cells treated with the selected extract were observed by phase contrast microscopy. The cells were incubated with increasing concentrations of microalgal extracts for 24, 48, and 72 h, and cell viability was determined by the Sulforhodamine B (SRB) assay. After treatment of cancerous cells with microalgal extract for 48 h, 55% of the cells were viable, 38% were in early apoptosis, 5% were in late apoptosis, and 1% exhibited necrosis. Further studies are needed to discover the mechanisms underlying the antiproliferative activity of microalgal extracts against cancer cell lines and to identify specific bioactive compounds that are responsible for the observed activities
An Exploration of the Pulmonary Complication of the Treatment in Psoriatic Patients Receiving Topical, PUVA and Methotrexate Therapy
Authors: Akhter Tunergina , Begum Shelina , Khanam Afroza , Akhtary Syeda Muslema , Ul-Alam SM Akhter – , Nahar Nasrin , Afreen Khandakar Nadia
Published: May 2022

Background: In Bangladesh the prevalence rate of psoriasis is 1.49%. Although this rate of prevalence rate is not so high but in patient’s traditional treatment procedure, physicians have to aware about the exploration of the pulmonary complication of the treatment in psoriatic patients receiving topical, PUVA and Methotrexate Therapy. Aim of the study: The aim of this study was to compare the lung function test results among the psoriatic patients receiving topical, PUVA and Methotrexate therapy in order to explore the pulmonary complication of the treatment. Methods: This cross-sectional study was carried out in the Department of Physiology of Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbag, Dhaka, from July 2012 to June 2013. A total number of 120 subjects were selected, among which 30 were apparently healthy subjects (control group-A) for comparison and 90 were diagnosed male Psoriatic patients (study Group-B). Controls were selected from the community and the patients from the Indoor and Out Patient Department (OPD) of Dermatology and Venereology, BSMMU, Dhaka. Based on treatment, these study subjects were further divided into three groups consists of 30 male subjects in each group. These were group B1 (30 diagnosed male Psoriatic patient receiving only topical therapy), B2 (30 male Psoriatic patients receiving PUVA therapy, B3 (30 male Psoriatic patients receiving Methotrexate therapy). Results: In this study, all the control subjects (A) were with normal lung function tests (LFT). On the contrary, 19, 20 and 29 psoriatic patients were with abnormal lung function tests in the experimental groups B1, B2 and B3 respectively. The results were shown in Table IV. Decreased FVC was detected in patients of Psoriasis belonged to total 48(53.33%) out of 90 patients. Among them 10(33.33%) were in group B1, 13 (43.33%) in group B2 and 25 (83.33%) in group B3. Decreased FEV1 was detected in patients of Psoriasis belonged to total 43(47.78%) out of 90 patien
Primary biliary cholangitis (PBC) - autoimmune hepatitis (HAI) overlap syndrome (OS)
Authors: Benjouad Karima , Ouaya Hassan , Aboutarik fatima-zahra , Errami Adil Ait , Oubaha Sofia , Samlani Zouhour , Krati Khadija
Published: May 2022

The AIH-PBC overlap syndrome is the most common form of OS. The aim: to study the clinical and paraclinical characteristics of the overlap syndrome and to specify the therapeutic and evolutionary characteristics. Methods: The medical data of 42 PBC patients were evaluated for associated autoimmune hepatitis. Results: Among the 42 cases of PBC, we retained 16 cases of OS (37%). All female the association of diagnostic criteria for PBC and HAI was simultaneous in 80%. Treatment with AUDC, corticosteroid and Azathioprine was started in the majority of our patients. The course was marked by a complete (10 cases) or incomplete (n = 6) response. Conclusion: OS should be considered in the presence of any mixed cytolytic and cholestatic liver disease. Its recognition is essential in order to adapt treatment and prevent progression to cirrhosis and its complications.
Prevalence, Intensity of Infection and Co-infections of Soil-Transmitted Helminths among Students of the University Félix Houphouët-Boigny in the south of Ivory Coast
Authors: N’gbesso N’gbesso Jean-Paul , Loukouri Agodio , Okoubo Nicaise Aya N’guessan Epse , Cissé Doumbia Mariamou , Mambey Serge , Kouadio Myékinan sarah Soro Epse , constantin Ahoua A. Aimé
Published: May 2022

Soil-Transmitted Helminths (STH) are public health problem in the world and particularly in developing countries. This study initiated at the University Félix Houphouët-Boigny of Cocody (Abidjan - Ivory Coast) aims to determine the level of prevalence, the intensity of infestation and co-infections due to Soil-Transmitted Helminths and the various associated factors. The Mini Flotac technique combined with a questionnaire was the method used to achieve the set objective. The study resulted in prevalence rates of 23.45% for Ascaris lumbricoides, 16.81% for Trichuris trichura and 0.88% for Ankylostoma spp. Co-infection of Ascaris lumbricoides and Trichuris trichiura was identified, i.e. a prevalence of 7.96%. The logistic regression model showed that Ascaris lumbricoides infection is associated with property in university toilets (OR=2.53, p≤0.05). This study made it possible to initiate an integrated control programme against Soil-Transmitted Helminths in general and Ascaris lumbricoides and Trichuris trichura infection in particular at Félix Houphouët-Boigny University.
Radiotherapy of Localized Endometrial Cancer, Experience of The Radiation Oncology Department of The Oncology-Hematology Center of The CHU Mohammed VI of Marrakesh: About 85 Cases
Authors: A El Matlini , Y Bouchabaka , M Raouah , M Darfaoui , I Lalya , A El Omrani , M Khouchani
Published: May 2022

Endometrial cancer is the most common gynecological cancer in developed countries. It mainly concerns postmenopausal women. The objective of our work is to report the experience of the radiotherapy oncology department of the oncology-hematology hospital (HOH) of the Mohammed IV University Hospital of Marrakesh in the management of endometrial cancer. We retrospectively analyzed 85 cases of endometrial cancer treated by radiotherapy (external radiotherapy and /or brachytherapy) in our institution between 2014 and 2019. The data collected from our patients concerned the epidemiological, clinical, therapeutic and evolutionary aspects of this cancer. The median age of the patients was 58 years [37, 82], 88% were postmenopausal. The average consultation time was 08 months. The master symptom was post-menopauseal bleeding in 85% of the patients. Pathological examination showed endometrioid adenocarcinoma in 83% of cases. After workup, 51% of patients were stage I (IA 17%, IB 35%), 25% stage II, 23% stage III (IIIA 3%, IIIB 9% and IIIC 10%) and 1% stage IVA according to the classification of the International Federation of Obstetric Gynecology (FIGO). After surgery, 77% of patients received external beam radiation therapy. The dose delivered was between 46 and 50 Gray (Gy) over a mean spread of 42 days associated with concomitant chemotherapy in 16% of cases. Intravaginal brachytherapy was delivered to 98% of patients. It represented the only adjuvant treatment in 27% of cases, after external radiotherapy in 73% of cases. Adjuvant chemotherapy was received in 36% of patients. After a mean follow-up of 3 years, 82% of patients were still followed in a situation of good control of their disease, 8% of cases of local recurrence and 10% of distant metastasis.
Selection of Detergents Suitable for IBMR3 (Mab) using Balb/c Mouse Muscle
Authors: Alrawi Qutaiba K. J. , Nada Nada , Alzubydy S.
Published: May 2022

Monoclonal antibodies (Mab) and their fragments have been widely used for diagnostic and therapeutic purposes. Monoclonal antibodies IBMR3 hybridoma cells were produced in a previous study. In my study I used four types of detergents to fine the more suitable as the best Lysis buffer for monoclonal anti bodies using Balb/ c mouse tissue muscle. The four detergents includes; NP- 40, Igepal, Chaps and Triton X-100. Detergents were used in the laboratory to solubilize biological macromolecules such as proteins. These are none denaturing solvents; they also increase emulsification and solubilization, act as solubilize membrane proteins in their native state. The mouse samples were lysed in different lysis buffer detergents, the extracting protein where subjected on the SDS-PAGE electrophoresis, the separated protein bands were transferred to PVDF/ Polyvinylidene difluoride membrane for Immunoblotting technique. The immunblot were subsequently subjected to densitometry analysis to get the value of molecular weight, peak height and raw volume of the protein band. The results of muscle protein concentration of Blab/c mouse after using standard methods were shown (NP-40, 3.214 μg / μl), (Igepal, 3.647 μg / μl), (CHAPS, 3.925 μg / μl and Triton X-100, 4.214 μg / μl). The highest concentration of the muscle protein was obtained from using Triton X-100, followed by CHAPS, then by Igepal and in NP- 40.