bluuebunny/crossref_metadata_2025 huggingface dataset:
Implementasi Sistem Pelayanan Administrasi Kependudukan Desa di Kantor Desa Karya Makmur
Authors: Firra Katria Almabilla , Fujianti Linda , Yang Yang Agita Rindri
Published: February 2025

Currently, technological developments continue to develop rapidly so that more and more digitalization is used by people around the world to carry out activities in various aspects, one of which is village digitalization which is used for community service activities. The village used as the research object is Karya Makmur village which is located in Pemali District, Bangka Regency, Bangka Belitung Islands Province. Karya Makmur Village faces challenges in aligning population administration processes with developments in information technology. Implementation of a population administration service system that is integrated with online mail services, payment of village fees using QR-Code, and deadline reminders via WhatsApp Gateway are strategic solutions to improve service quality. In contrast to previous research which still focused on manual systems, this research offers an innovative digital approach to simplify the administrative service process at the village level. The method applied involves direct observation, interviews and literature studies to understand the population administration service system. The Prototyping Method is a method used as a systematic development method. The results of the evaluation of the population administration service system using the User Acceptance Testing (UAT) method show that this system can be considered feasible and effective for use with a success percentage reaching 95.38 percent. Thus, this population administration system makes the process of providing services to the community in Karya Makmur village more efficient.
Rancang Bangun Sistem Cerdas Pengontrolan Keamanan Kunci Kontak dan Pelacakan Pada Sepeda Motor Berbasis IOT
Authors: Sulistyo Eko , Santrila Hafizra , Haikel M. Zuhriyandi , Ocsirendi Ocsirendi
Published: February 2025

The ignition key security system and motorcycle tracking are very important features that a motorcycle must have to secure the motorcycle from theft. The problem that occurs is that the key security system on motorbikes currently uses keyless and can only control one motorcycle and is not equipped with a tracking system, making it difficult for users to track the location of the motorcycle during theft. Therefore, this research will develop an ignition lock security system using keyless through an intelligent system application on android and equipped with a password to turn on or off more than one motorcycle to make it more efficient and cost-effective. While the tracking system is an additional feature developed in this research to track the whereabouts of motorbikes via android based on the location point and coordinates. The research method used in the ignition lock security system is to connect a 2-channel relay to the motorcycle electricity through NodeMCU which will control it through the application. Meanwhile, the tracking system uses the Neo-6M GPS Module to track the coordinates of the motorcycle location via GPS satellites. The results of the tracking are then sent to firebase to be processed into a motorcycle location point on the smartphone application. The test results show that the application can turn off and turn on more than one motorcycle using different passwords through the application on a smartphone and can display the location point of the motorcycle with a very small coordinate difference between the application and google maps so that it is considered to have a percentage error of 0%.
Pengendalian Filamen Bubbling Dari Material Petg Pada Proses Cetak 3 Dimensi
Authors: Adam Adam Ridho , Ramadhan Ali
Published: February 2025

Pengendalian adalah pengukuran dan perbaikkan terhadap suatu pelaksanaan agar pelaksanaan sesuai dengan rencana yang telah dibuat untuk mencapai suatu tujuan. Bubbling merupakan salah satu kegagalan dalam proses cetak 3d print, hal ini bisa terjadi di sebabkan karena filamen yang lembab/mengandung banyak kadar air, Mencetak sebuah objek 3D membutuhkan ketelitian karena semua aspek persiapan harus di lakukan dengan baik sehingga nantinya objek yang di cetak berhasil dengan baik, Dalam penelitian ini penulis menggunakan jenis penelitiann studi kasus, penulis akan melakukan deskripsi dan analisis dari kasus filamen bubbling. analisis yang di lakukan adalah menganalisis faktor yang mempengaruhi filamen material PETG menjadi lembab dan analisa terhadap metode penyimpanan material PETG yang tepat supaya kualitas material tetap optimal.
Akurasi Pendeteksian Berdasarkan Parameter Jarak, Jumlah Obyek dan Kekeruhan Air pada Obyek Bergerak Jentik Nyamuk
Authors: Febriansyah Aan , Surojo Surojo , Pangestu Rafif Tri , Karimah Savira
Published: February 2025

Sistem pendeteksian keberadaan jentik nyamuk dapat dijadikan salah satu solusi untuk mengetahui apakah wadah penampungan air tersebut sehat atau tidak. Sistem pendeteksian jentik nyamuk ini menggunakan beberapa parameter ukur, antara lain jarak obyek jentik nyamuk dengan kamera, kondisi kekeruhan air/kondisi cahaya, dan jumlah jentik nyamuk yang ada pada penampungan air tersebut. Dari hasil pengujian yang dilakukan pada parameter jarak pendeteksian didapatkan hasil bahwa sistem dapat mendeteksi keberadaan jentik nyamuk dalam rentang jarak 5-15 cm dengan kondisi air jernih/cahaya terang dengan tingkat keberhasilan deteksi di atas 80%. Pada pengujian yang sama, namun dengan kondisi air keruh/cahaya gelap, pendeteksian berjalan dengan baik namun terjadi kesalahan deteksi pada jarak 15cm yaitu sistem mendeteksi obyek selain jentik nyamuk sebagai jentik nyamuk. Hal ini disebabkan beberapa faktor, antara lain minimnya variasi dataset, sistem pendeteksian yang dilakukan secara real-time (berupa video capture) dan spesifikasi kamera yang digunakan belum mencukupi nilai minimum yang disyaratkan oleh sistem komputasi
Studi Potensi Pembangkit Listrik Ramah Lingkungan Bertenaga Angin Di Pesisir Pantai Turun Aban Desa Matras Bangka
Authors: Pranandita Nanda , Rollastin Boy , Hidayat Rizal Tegu , Alzamanur Salas
Published: February 2025

Natural reisourceis such as wind can bei an alteirnativei for poweir geineiration through thei usei of wind turbineis. Onei impleimeintation is thei deiveilopmeint of reineiwablei eineirgy in poteintial locations, such as Turun Aban Beiach in Matras Villagei, Bangka, Bangka Beilitung Islands. This beiach is oftein useid as an anchoragei for fishing boats, but doeis not yeit havei an eileictric poweir supply. To meieit theiir neieids, fisheirmein can utilizei wind turbineis as an alteirnativei poweir geineiration option. Thei teist reisults show that at an aveiragei wind speieid of 1.97 m/s, thei wind turbinei produceis 3.96 watts of poweir
Heightened Blood Pressure, but not Pulse Rate, Response to Orthostatic Challenge in Normotensive Subjects with Family History of Hypertension
Authors: Awisarita Wiwara , Jenie Ikhlas Muhammad
Published: February 2025

Whether exaggerated cardiovascular response to postural changes among normotensive subjects with family history of hypertension does exist is not reported yet. Male and female normotensive subjects with (n=16) and without (n=14) hypertensive parents did postural changes from supine to standing. Systolic blood pressure, diastolic blood pressure and pulse rate were measured during supine and immediately after standing. The median value of the delta systolic blood pressure, diastolic blood pressure and pulse rate from all samples were used to classified exaggerated cardiovascular responses. The differences in the proportion of subjects with exaggerated cardiovascular responses were analysed with Chi square. P value <0.05 was considered significant. Proportion of normotensive subjects who had exaggerated systolic (≥3.5 mm Hg) or diastolic (≥2 mm Hg) blood pressure responses to postural changes were significantly higher in those with parental history of hypertension as compared to those without parental history of hypertension. Proportion of subjects who had exaggerated pulse rate (≥12 bpm) response to postural changes was not significantly different between the two groups. Normotensive young adults with family history of hypertension demonstrated heightened blood pressure, but not pulse rate, responses to orthostatic challenge from supine to standing.
Clinical Characteristics and Management of Pediatric Eye Trauma in National Tertiary Eye Hospital in Indonesia
Authors: Axa Alya Putri , Amiruddin Primawita Oktarima , Caesarya Sesy
Published: February 2025

Eye trauma is a major cause of vision problems in children, leading to visual impairment and blindness. This issue has significant global implications, affecting children psychologically and socially. According to the American Academy of Pediatrics, 66% of all eye traumas occur in individuals under 16, with the highest occurrence between ages 9 and 11. We conducted a retrospective descriptive study using medical records of pediatric patients aged 0 - 18 years who experienced eye trauma from January to December 2022 at the National Eye Center-Cicendo Eye Hospital. There were 190 patients included in this study. The majority of patients were male (69.47%) and the most common age group affected was 6 - 12 years (33.16%). Leading causes of eye trauma were blunt trauma (58.95%). The common management for eye trauma in this study is operative or medical procedures (67,37%) This study provides valuable information on the characteristics and management of eye trauma in children, which can contribute to the development of prevention strategies and appropriate interventions. Understanding the patterns of eye trauma and implementing comprehensive care can help prevent blindness and minimize visual impairment.
 
Keywords: Eye Trauma; Children; Management
Characteristics of Hysterosalphingography Findings in Infertile Patients at Prof. Dr. I.G.N.G Ngoerah Central Hospital at Periode of January 2021 to June 2024
Authors: Firman Parulian Sitanggang  , Putu Patriawan  , Regina Primeylisa Dos Santos  , Agnes Caroline  , Gandis Ayu Wardani
Published: February 2025

Introduction: Infertility is the inability to achieve pregnancy after 12 months of regular unprotected intercourse, affecting millions globally. In Indonesia, it affects 10-15% of reproductive-aged couples. Infertility can be classified as primary (no prior pregnancies) or secondary (previous pregnancies). HSG is commonly used to assess uterine and tubal abnormalities, key contributors to infertility. Methodes: Descriptive qualitative study are done to examine correlation of age, uterine abnormalities, and fallopian tube abnormalities from HSG findings with the prevalence of infertility from patients in Radiology Department from Prof. Dr. I.G.N.G. Ngoerah Central General Hospital, covering the period from January 2021 to June 2024.Results: 66 patients were collected as samples. 47 patients (71.21%) have primary infertility, while 19 patients (28.79%) have secondary infertility. 9 patients (13.63%) have uterus abnormalities, while 21 patients (31.81%) have fallopian tube abnormalities.Discussion: Hysterosalpingography (HSG) is a key diagnostic tool in evaluating infertile patients, providing insights into uterine and fallopian tube morphology and patency. It detects structural abnormalities like retroflexed uterus, didelphys, or blocked tubes, which can hinder sperm-egg interaction, embryo implantation, or cause recurrent miscarriages, affecting fertility.
Keywords:  Abnormalities, Fallopian tube, Hysterosalphyngography, Infertiliy, uterus
Optimizing intranasal mesenchymal stem cell therapy for neonatal brain injury: advancing therapeutic approaches and strenghtening insights
Authors:   , Hermans Eva Colette
Published: February 2025

Neonatal hypoxic-ischemic (HI) brain injury is a leading cause of long-term neurological impairment in newborns. While current treatments are limited, intranasal mesenchymal stem cell (MSC) therapy has shown safety in humans and the potential to repair HI brain injury in preclinical studies. Although its potential, MSC therapy remains only partially effective and its mechanisms not fully understood. Notably, MSCs can be conditioned to improve efficacy and target specific repair processes. This thesis aimed to enhance intranasal MSC potency for treating HI brain injury by exploring various optimization strategies. This thesis provides novel insights into the chemotactic cues essential for migration of MSCs to the HI brain and identifies new targets for the future optimization of MSC migration. We demonstrated that hypoxic preconditioning is a promising optimization strategy to enhance the neuroregenerative and migratory potential of MSCs and thereby increases the therapeutic efficacy of intranasal MSC therapy. Additionally, we showed that while oral supplementation with lysophosphatidylcholine-bound n-3 polyunsaturated fatty acids provided neuroprotective effects as a standalone therapy, it did not provide additional therapeutic benefits on top of MSC therapy under the treatment regime investigated in this thesis. Lastly, we developed a novel method for assessing early neurodevelopmental outcome in social communication in a mouse model for neonatal HI brain injury, allowing the investigation of causes of and treatments for social communication impairments following HI. Altogether, this thesis demonstrates that by deepening our understanding of the mechanisms underlying intranasal MSC therapy for the neonatal HI-injured brain and by enhancing treatment efficacy, we are moving closer to implementing optimized MSC therapy for diverse populations of infants with neonatal brain injury, thereby advancing their future prospects.
Perancangan Strategis Menggunakan Balance Scorecard Pada Framework Ward & Peppard (Studi Kasis WeChat Pay)
Authors: Ashfa Fikriya Arina , Havid Achmad , Zuchrotunisa  , Deagita Nisa’ , Nisa Sa’diatun
Published: February 2025

WeChat Pay adalah perusahaan yang berfokus pada layanan finansial elektronik. Seiring dengan pesatnya perkembangan era digital, banyak e-wallet baru yang bermunculan. Untuk tetap kompetitif dan bertahan dalam persaingan yang semakin ketat, WeChat Pay perlu merumuskan strategi bisnis yang tepat. Salah satu langkah penting adalah merencanakan strategi dalam mengembangkan WeChat Pay dengan baik. Oleh karena itu, tujuan dari makalah ini adalah untuk menyusun rencana strategis WeChat Pay, yang dapat memberikan kontribusi yang baik, serta inovatif dalam mendukung pencapaian tujuan strategi bisnis guna meningkatkan daya saing dalam layanannya. Makalah ini mengadopsi kerangka kerja Ward dan Peppard untuk merencanakan strategi sistem informasi serta mengevaluasi faktor internal dan eksternal lingkungan bisnis. Perencanaan strategis bisnis WeChat Pay dianalisis menggunakan Balance Scorecard, sementara portofolio aplikasi WeChat Pay dipetakan menggunakan Strategic Grid McFarlan Analysis. Pada akhirnya, makalah ini memberikan rekomendasi untuk organisasi, antara lain: peningkatan performa layanan, manajemen hubungan pelanggan, pelatihan dan sertifikasi karyawan, ekspansi pasar, serta integrasi dengan e-wallet lainnya.
Beyond Cause and Consequence: Addressing the Complexities of Mood Disorders and Circadian Rhythms by Including Lived Experience
Authors: Downs James
Published: February 2025

The interplay between circadian rhythm disruption and mood disorders brings to life the complexity involved in comprehending the entangled nature of human experience, inviting us to look beyond surface-level symptoms and consider the broader impacts on daily life and well-being. Preliminary research indicates that, in addition to mood disorders such as depression being associated with unsettled natural rhythms, disrupted circadian processes can in themselves precipitate or intensify mood disorder symptoms (Fishbein et al., 2021; Walker et al., 2020). Responding to the question, “Are sleep and circadian rhythm disturbances the cause or simply the consequence of depression or other mood disorder subtypes?” (Hickie et al., 2024), I will draw on both my subjective, lived experiences alongside published research to illustrate how these disturbances are rarely unidirectional. My analysis demonstrates the cyclical interplay of circadian processes and mood which makes it necessary to address both aspects concurrently in mental health science and clinical practice. More than this, subjective accounts such as my own make clear the need for treatment approaches - and research methodologies - that genuinely incorporate the perspectives of lived experience to capture the full complexity of intertwined phenomena.
Is platelet-rich plasma better than steroids as epidural drug of choice in lumbar disc disease with radiculopathy? Meta-analysis of randomized controlled trials
Authors: Muthu Sathish , Viswanathan Vibhu Krishnan , Gangadaran Prakash
Published: February 2025

The current meta-analysis was performed to analyze the efficacy and safety of platelet-rich plasma (PRP) as an epidural injectate, in comparison with steroids in the management of radiculopathy due to lumbar disc disease (LDD). We conducted independent and duplicate searches of the electronic databases (PubMed, Embase and Cochrane Library) in March 2024 to identify randomized controlled trials (RCTs) analyzing the efficacy of epidural PRP for pain relief in the management of LDD. Animal or in vitro studies, clinical studies without a comparator group, and retrospective or non-randomised clinical studies were excluded. Diverse post-intervention pain scores [visual analog score (VAS)] and functional scores [Oswestry Disability Index (ODI), SF-36], as reported in the reviewed studies, were evaluated. Statistical analysis was performed using STATA 17 software. 5 RCTs including 310 patients (PRP/Steroids = 153/157) were included in the analysis. The included studies compared the efficacy and safety of epidural PRP and steroids at various time-points including 1, 3, 6, 12, 24, and 48 weeks. Epidural PRP injection was found to offer comparable pain relief (VAS; WMD = −0.09, 95% CI [−0.66, 0.47], p = 0.641; I2 = 96.72%, p < 0.001), functional improvement (ODI; WMD = 0.72, 95% CI [-6.81, 8.25], p = 0.524; I2 = 98.73%, p < 0.001), and overall health improvement (SF-36; WMD = 1.01, 95% CI [−1.14, 3.17], p = 0.224; I2 = 0.0%, p = 0.36) as epidural steroid injection (ESI) at all the observed time points in the included studies without any increase in adverse events or complications. Epidural administration of PRP offers comparable benefit as epidural steroid injection (ESI) in the management of radiculopathy due to LDD. The safety profile of the epidural PRP is also similar to ESI.
Functionalized conductive polymer composites for tissue engineering and biomedical applications- a mini review
Authors: Gayathri V. , Khan Tabrej , Gowtham M. , Balan R. , Sebaey Tamer A.
Published: February 2025

Tissue engineering (TE) has emerged as a promising therapeutic strategy, employing artificial scaffolds to regenerate functional cardiac tissue and offering new hope for innovative treatment approaches. A straightforward method for producing biodegradable, conductive polymer-based composites involves blending conductive polymers directly with biodegradable ones. This approach’s flexibility enables the development of diverse biodegradable, conductive polymer scaffolds, which have been extensively explored in tissue engineering and regenerative medicine. While this technique successfully combines the advantages of both polymer types, it may face challenges such as potential compromises in conductivity and biodegradability. This review emphasizes the potential to tailor degradation rates and conductivity by selecting appropriate polymer types and ratios, ensuring adaptability for various biomedical applications.
Responsive nanomaterials in biomedicine, patent path and prospect analysis
Authors: Liu Xinrui , Yuan Hongmei
Published: February 2025

In recent years, responsive nanomaterials have demonstrated tremendous potential in biomedical applications due to their unique advantages in precise drug delivery and controlled release. For complex diseases such as cancer, chronic inflammation, and genetic disorders, traditional treatment methods are often limited by insufficient targeting and significant side effects. Responsive nanotechnology, by sensing specific internal or external stimuli, has significantly enhanced the precision and efficiency of treatments. This study systematically summarizes the technological trajectory and emerging research directions of responsive nanomaterials through global patent and literature data, employing main path analysis, derivative path analysis, and keyword co-occurrence analysis. The results reveal the evolution of this field, from the optimization of early single-stimulus-responsive nano delivery systems to the rise of theranostics integration, followed by advancements in multi-stimuli-responsive synergistic therapies, and finally, the innovation in biomimetic material design. Each developmental phase has increasingly focused on adapting to complex biological environments, achieving superior targeting performance, and enhancing therapeutic efficacy. Keyword co-occurrence analysis highlights key research hotspots, including biomimetic design, multimodal synergistic therapies, and emerging response mechanisms. In the future, responsive nanomaterials are expected to play a pivotal role in personalized medicine, multifunctional carrier design, and complex disease management, providing novel insights and technological support for precision medicine.
Adherence to a digital therapeutic mediates the relationship between momentary self-regulation and health risk behaviors
Authors: Plaitano Enzo G. , McNeish Daniel , Bartels Sophia M. , Bell Kathleen , Dallery Jesse , Grabinski Michael , Kiernan Michaela , Lavoie Hannah A. , Lemley Shea M. , Lowe Michael R. , MacKinnon David P. , Metcalf Stephen A. , Onken Lisa , Prochaska Judith J. , Sand Cady Lauren , Scherer Emily A. , Stoeckel Luke E. , Xie Haiyi , Marsch Lisa A.
Published: February 2025

Introduction

Smoking, obesity, and insufficient physical activity are modifiable health risk behaviors. Self-regulation is one fundamental behavior change mechanism often incorporated within digital therapeutics as it varies momentarily across time and contexts and may play a causal role in improving these health behaviors. However, the role of momentary self-regulation in achieving behavior change has been infrequently examined. Using a novel momentary self-regulation scale, this study examined how targeting self-regulation through a digital therapeutic impacts adherence to the therapeutic and two different health risk behavioral outcomes.

Methods

This prospective interventional study included momentary data for 28 days from 50 participants with obesity and binge eating disorder and 50 participants who smoked regularly. An evidence-based digital therapeutic, called Laddr™, provided self-regulation behavior change tools. Participants reported on their momentary self-regulation via ecological momentary assessments and health risk behaviors were measured as steps taken from a physical activity tracker and breathalyzed carbon monoxide. Medical regimen adherence was assessed as daily Laddr usage. Bayesian dynamic mediation models were used to examine moment-to-moment mediation effects between momentary self-regulation subscales, medical regimen adherence, and behavioral outcomes.

Results

In the binge eating disorder sample, the perseverance [β1 = 0.17, 95% CI = (0.06, 0.45)] and emotion regulation [β1 = 0.12, 95% CI = (0.03, 0.27)] targets of momentary self-regulation positively predicted Laddr adherence on the following day, and higher Laddr adherence was subsequently a positive predictor of steps taken the same day for both perseverance [β2 = 0.335, 95% CI = (0.030, 0.717)] and emotion regulation [β2 = 0.389, 95% CI = (0.080, 0.738)]. In the smoking sample, the perseverance target of momentary self-regulation positively predicted Laddr adherence on the following day [β = 0.91, 95% CI = (0.60, 1.24)]. However, higher Laddr adherence was not a predictor of CO values on the same day [β2 = −0.09, 95% CI = (−0.24, 0.09)].

Conclusions

This study provides evidence that a digital therapeutic targeting self-regulation can modify the relationships between momentary self-regulation, medical regimen adherence, and behavioral health outcomes. Together, this work demonstrated the ability to digitally assess the transdiagnostic mediating effect of momentary self-regulation on medical regimen adherence and pro-health behavioral outcomes.

Clinical Trial Registration

ClinicalTrials.gov, identifier (NCT03774433).
Organic geochemical characteristics of Jurassic Yan ’an Formation source rock in Pengyang area of southwestern Ordos basin
Authors: Zhu Yaling , Tan Wenmei , Hai Lianfu , Mu Caixia , Wang Kun , Li Mengyuan
Published: February 2025

The Jurassic Yan ’an Formation in the southwestern margin of Ordos Basin has developed many sets of coal-associated and non-associated mudstone as well as oil shale. Different analytical methods including total organic carbon (TOC), Rock-Eval pyrolysis, and conventional biomarker analyses were applied on the mudstone, the coal and the oil shale extracts to unravel their organic geochemical characteristics and the paleo depositional environment. Results reveal that all the source rock samples are immature to mature with good petroleum generation potentials. The redox environment is generally reducing. The organic matter input is mainly terrestrial higher plants. The low Ga/C30 hopane ratio of all the samples indicate the low salinity of the paleo-water column. The oil shale samples show much higher thermal maturity than the coals and mudstones as indicated by the higher C31 homohopane isomerization indexes, C32 homohopane isomerization indexes and the C29 sterane ααα20S/(S + R) ratios. The depositional environment of the oil shale is more reduced compared to the coals and mudstones as can be reflected by the low oxygen index and the higher C35 hopane/(C31-C35 homohopanes) ratios. Thus, the oil shale layers should be the target of the next exploration and development. And the Oil shale and coal can be exploited simultaneously in Pengyang area.
A systematic literature review on the importance of teacher recruitment and retention in global educational reform
Authors: Shaoan Md Mirajur Rhaman , Namanyane Tebatso , Feng Meiqi , Arif Muhammad
Published: February 2025

This study conducts various economic approaches implemented worldwide to augment teachers’ recruitment and retention. It commences by situating the criticality of teacher recruitment and retention within the broader ambit of educational expansion and reform worldwide. Each nation prioritizes recruiting and retaining high-caliber educators, acknowledging the critical role that remuneration and additional professional opportunities play in attracting and sustaining individuals within the teaching profession. This systematic literature review analyzes the Economic approaches to teacher recruitment and retention. Using the PRISMA (Preferred Reporting Items for Systematic Review and Meta-analysis Protocols Statement), this literature review is those articles successfully published between 2017 and 2023. The study uses two well-known internet sources: Web of Science and Scopus. There are 215 publications, including 15 papers with the most citations for this thorough literature study. This study emphasizes the importance of economic incentives, such as salary and professional development opportunities, in attracting and retaining skilled teachers in educational institutions. This study finds that policymakers and educational administrators worldwide have pertinent insights and data poised to aid in formulating more efficacious economic strategies for recruiting and retaining teachers. The recommendations are based on a nuanced understanding of the interplay between financial factors and educational efficacy, seeking to inform future policy directions and academic discourse in this field.
Digital intelligence technology and curriculum ideology in sports colleges: the mediating roles of teaching effectiveness and student engagement
Authors: Wang Ziqi , Bu Xiangui , Hong Siyu , Jia Zixuan , Huang Zeqi , Wang Wenjun
Published: February 2025

Introduction

This study explores the role of digital intelligence technology (DIT) in indirectly enhancing curriculum ideological effectiveness in sports colleges through improvements in teaching effectiveness and student engagement. The research provides insights into how technology integration can influence ideological and political education outcomes.

Methods

A nationwide sample of 804 faculty and student respondents was analyzed using a chain mediation model grounded in the Technology Acceptance Model, Self-Determination Theory, and Educational Ecosystem Theory. Structural Equation Modeling (SEM) was applied to examine the relationships between DIT, teaching effectiveness, student engagement, and curriculum ideology outcomes.

Results

The findings reveal that DIT significantly enhances teaching effectiveness and student engagement, which sequentially contribute to improved curriculum ideology outcomes. Student engagement accounted for a greater proportion of variance compared to teaching effectiveness, emphasizing the critical role of interactive learning in ideological and political education.

Discussion

This study introduces a novel chain mediation pathway—DIT → Teaching Effectiveness → Student Engagement → Curriculum Ideology—highlighting the synergistic relationship between teaching quality and learner participation. The findings provide theoretical contributions to understanding technology integration in sports education and practical recommendations for professional development and interactive classroom practices to optimize the impact of DIT.
Energy-efficient analog-domain aggregator circuit for RRAM-based neural network accelerators
Authors: Humood Khaled , Pan Yihan , Wang Shiwei , Serb Alexander , Prodromakis Themis
Published: February 2025

Recently, there has been notable progress in the advancement of RRAM-based Compute-In-Memory (CIM) architectures, showing promise in accelerating neural networks with remarkable energy efficiency and parallelism. However, challenges persist in fully integrating large-scale networks onto a chip, particularly when the weights of a layer exceed the capacity of the RRAM crossbar. In such cases, weights are distributed across smaller RRAM crossbars and aggregated using tree adders and shifters in digital flow, leading to increased system complexity and energy consumption of hardware accelerators. In this work, we introduce a novel energy-efficient analog domain aggregator system designed for RRAM-based CIM systems. The proposed circuit has been verified and tested using Virtuoso Cadence circuit tools in 180 nm CMOS technology with post-layout simulations and analysis. Compared with the digital adder tree approach, the proposed analog aggregator offers improvements in three key areas: it can handle an arbitrary number of inputs not just powers of 2, achieves lower error through better rounding and improves power efficiency (2.15× lower consumption). These findings mark a substantial advancement towards the full implementation of efficient on-chip hardware accelerator systems.
Dynamic changes in peripheral blood lymphocyte trajectory predict the clinical outcomes of sepsis
Authors: Li Dongkai , Zhang Jiahui , Cheng Wei , Zhao Guoyu , Lei Xianli , Xie Yawen , Cui Na , Wang Hao
Published: February 2025

Background

Sepsis induces profound derangements in the immune system, including lymphopenia, which correlates with immunosuppression and poor prognosis. However, most evaluations of immunosuppression in sepsis patients rely on static, sporadic lymphocyte counts, lacking dynamic modeling over the disease course. This study aimed to apply latent class mixed modeling on longitudinal lymphocyte counts to uncover heterogeneous trajectory phenotypes in sepsis patients and assess their predictive value for clinical outcomes.

Results

Four lymphocyte trajectory phenotypes were identified in the retrospective cohort (n=2,149) and externally validated (n=2,388): high–declining (α, 3.8%), stable–medium (β, 69.3%), high–increasing (γ, 3.2%), and stable–low (δ, 23.8%). The α phenotype exhibited the highest disease severity and mortality (25.9%) compared with other phenotypes in both cohorts. In the prospective cohort (n=1,056), all lymphocyte subset counts differed among phenotypes on admission (P <.001) and were lower in non-survivors (P<.05). Multivariable regression demonstrated that age, Acute Physiology and Chronic Health Evaluation-II score, heart rate, natural killer cell count, infection source, and lymphocyte trajectory phenotype were independent predictors of 28-day mortality. A nomogram combining these variables provided individualized risk estimations.

Conclusions

The lymphocyte trajectories delineated novel dynamic phenotypes associated with divergent sepsis outcomes. Incorporating longitudinal trajectory modeling and lymphocyte subsets may improve prognostic risk assessment and guide the selection of immunotherapies tailored to specific immune phenotypes in sepsis patients.

Clinical trial registration

https://www.chictr.org.cn/showproj.aspx?proj=18277, identifier ChiCTR-40 ROC-17010750.
Multiple programmed cell death patterns predict the prognosis and drug sensitivity in gastric cancer
Authors: Song Qiying , Liu Shihe , Wu Di , Cai Aizhen
Published: February 2025

Background

Gastric cancer (GC) is a malignant tumor with poor prognosis. The diverse patterns of programmed cell death (PCD) are significantly associated with the pathogenesis and progression of GC, and it has the potential to serve as prognostic and drug sensitivity indicators for GC.

Method

The sequencing data and clinical characteristics of GC patients were downloaded from The Cancer Genome Atlas and GEO databases. LASSO cox regression method was used to screen feature genes and develop the PCD score (PCDS). Immune cell infiltration, immune checkpoint expression, Tumor Immune Dysfunction and Exclusion (TIDE) algorithm and drug sensitivity analysis were used to explore immunotherapy response. By integrating PCDS with clinical characteristics, we constructed and validated a nomogram that demonstrated robust predictive performance.

Results

We screened nine PCD-related genes (SERPINE1, PLPPR4, CDO1, MID2, NOX4, DYNC1I1, PDK4, MYB, TUBB2A) to create the PCDS. We found that GC patients with high PCDS experienced significantly poorer prognoses, and PCDS was identified as an independent prognostic factor. Furthermore, there was a significant difference in immune profile between high PCDS and low PCDS groups. Additionally, drug sensitivity analysis indicated that patients with a high PCDS may exhibit resistance to immunotherapy and standard adjuvant chemotherapy regimens; however, they may benefit from the FDA-approved drug Dasatinib.

Conclusion

Overall, we confirmed that the PCDS is a prognostic risk factor and a valuable predictor of immunotherapy response in GC patients, which provides new evidence for the potential application of GC.
Neoadjuvant chemotherapy combined with antiangiogenic therapy and immune checkpoint inhibitors for the treatment of locally advanced gastric cancer: a real - world retrospective cohort study
Authors: Zhan Zhouwei , Chen Bijuan , Xu Shaohua , Lin Ruyu , Chen Haiting , Ma Xiaohuan , Lin Xuanping , Huang Wanting , Zhuo Changhua , Chen Yu , Guo Zengqing
Published: February 2025

Background

Although immune checkpoint inhibitors (ICIs) and anti-angiogenic drugs have demonstrated effectiveness in treating advanced gastric cancer (GC), their role in neoadjuvant or conversion therapy remains uncertain. This study aimed to evaluate the efficacy and safety of combining neoadjuvant chemotherapy with anti-angiogenesis and ICIs in patients with locally advanced GC (LAGC).

Methods

In this cohort study, we reviewed our prospectively maintained GC database and included individuals diagnosed with clinical stage II-III GC who received neoadjuvant therapy followed by surgery between January 2022 and August 2023. The treatment protocol combined ICIs, anti-angiogenic therapy (specifically apatinib), and chemotherapy (S-1 with oxaliplatin). A systematic approach was used to document patients’ clinical and pathological characteristics, pathological findings, and survival outcomes, which were subsequently analyzed in detail.

Results

A total of 38 individuals met the study’s inclusion criteria, with the majority (32 patients, 84.2%) having clinical stage III GC. All participants underwent surgery, resulting in a notable R0 resection rate of 97.4%. The rates of major pathological response (MPR) and pathological complete response (pCR) were 47.4% and 23.7%, respectively. Post-surgery, 36 patients (92.1%) received adjuvant chemotherapy. With a median follow-up of 22 months, ten patients experienced disease recurrence, including three who died from tumor relapse. The 1-year overall survival (OS) rate stood at 100%, and the disease-free survival (DFS) rate was 94.7%, with median OS and DFS yet to be reached. The neoadjuvant therapy regimen was generally well-tolerated, with no grade 5 treatment-related adverse events (TRAEs) reported. Only one patient experienced a grade 4 TRAE (immune-related hepatitis), while the most common grade 3 TRAEs included thrombocytopenia, elevated aminotransferase levels, and neutropenia.

Conclusions

The combination of neoadjuvant chemotherapy, anti-angiogenic therapy, and ICIs has proven effective in treating LAGC patients, achieving high pCR rates and favorable survival outcomes while maintaining an acceptable safety profile.
Pathogenic and therapeutic roles of extracellular vesicles in sepsis
Authors: You Benshuai , Yang Yang , Wei Jing , Zhou Chenglin , Dong Surong
Published: February 2025

Sepsis is a systemic injury resulting in vascular dysfunction, which can lead to multiple organ dysfunction, even shock and death. Extracellular vesicles (EVs) released by mammalian cells and bacteria have been shown to play important roles in intercellular communication and progression of various diseases. In past decades, the functional role of EVs in sepsis and its complications has been well explored. EVs are one of the paracrine components of cells. By delivering bioactive materials, EVs can promote immune responses, particularly the development of inflammation. In addition, EVs can serve as beneficial tools for delivering therapeutic cargos. In this review, we discuss the dual role of EVs in the progression and treatment of sepsis, exploring their intricate involvement in both inflammation and tissue repair processes. Specifically, the remarkable role of engineered strategies based on EVs in the treatment of sepsis is highlighted. The engineering EVs-mediated drug delivery and release strategies offer broad prospects for the effective treatment of sepsis. EVs-based approaches provide a novel avenue for diagnosing sepsis and offer opportunities for more precise intervention.
Use of 3D-DXA in the assessment of bone structure among patients with chronic kidney disease
Authors: Kužma Martin , Kužmová Zuzana , Humbert Ludovic , Picazo Mirella Lopez , Králik Roman , Falat Jakub , Smaha Juraj , Jackuliak Peter , Killinger Zdenko , Payer Juraj
Published: February 2025

Introduction

Patients in later stages of chronic kidney disease (CKD) have a 2- to 14-fold increase in fracture risk. Bone mineral density (BMD) assessment is limited due to the inability to measure trabecular and cortical bone characteristics and the interference of aortic calcifications.

Study objective

This study aimed to assess the trabecular bone score (TBS) and three-dimensional dual-energy X-ray absorptiometry (3D-DXA) in participants across all CKD stages.

Patients and methods

In total, 64 CKD patients (consisting of 28 female participants and 36 male participants, with an average age of 69.5 years) were included. There were 9, 12, 8, 9, 11, and 15 participants in stages G1, G2, G3a, G3b, G4, and G5 of CKD, respectively. BMD at the lumbar spine (LS) and proximal femur, as well as the LS TBS, were analyzed. The proximal femur parameters such as cortical and trabecular volumetric (v)BMD, cortical thickness (CTh), and surface (s)BMD at the total hip (TH) and femoral neck (FN) were analyzed using 3D-Shaper software.

Results

Comparison between the earlier stages (G1-G3a) and the later CKD stages (G3b-G5) showed significant differences in carboxy terminal collagen crosslinks (CTx) (386 vs.1053 ng/L), TH areal bone mineral density (aBMD; 0.991 vs. 0.859 g/cm2), cortical TH vBMD (831 vs. 795 mg/cm3), FN (837 vs. 788 mg/cm3), TH cortical sBMD (170 mg/cm2), and TH Cth (2.03 vs. 1.92 mm; all p < 0.05). Cross-sectional comparisons between each CKD stage showed a gradual decrease in the LS BMD, TH cortical vBMD, sBMD (FN and TH), and TH Cth. Strong positive associations between the glomerular filtration rate (GFR) and cortical parameters (FN/TH vBMD and TH Cth) were observed (p < 0.01).

Conclusion

In conclusion, advanced stages of CKD (G3b–G5) were associated with lower cortical bone parameters. The majority of the cortical parameters were correlated with the GFR, demonstrating a direct relationship between the kidney function and bone structure.
Severe pneumonia caused by Nocardia otitidiscaviarum in a patient with bronchiectasis and IgA nephropathy: a case report
Authors: Lin Yi , Jiang Zhao-Zhao , Chi Xiao-Qian , Chen Jian-Sheng , Wen Chao , Zhang Chao , Wang Ying-Ying , Xie Guang-Liang
Published: February 2025

Background

Nocardia species are rare opportunistic pathogens in the clinic, with strong invasiveness and dissemination, that can cause serious pulmonary infection, especially in immunocompromised patients, chronic lung diseases and hormone use, and is easy to be missed and misdiagnosed, preventing patients from obtaining timely and effective treatment, resulting in a high mortality rate.

Case presentation

Here, we present a rare case of a patient with chronic bronchiectasis and IgA nephropathy who developed Nocardia otitidiscaviarum pneumonia shortly after hormone therapy. The patient presented with tongue and lip ulcers, chest distress, cough, expectoration, and fever as the initial symptoms, which were extremely similar to common bacterial pulmonary infections. The laboratory examination and pulmonary computer tomography results indicated pulmonary infection, but the blood and multiple sputum cultures failed to identify the pathogen. Empirical treatment with piperacillin/tazobactam sodium and ceftriaxone was ineffective, and the patient’s condition worsened and progressed to respiratory failure. Subsequently, a bronchoscopy examination was performed, and the bronchoalveolar lavage fluid was collected for bacterial culture, which indicated Nocardia infection, however the treatment used of trimethoprim-sulfamethoxazole combined with imipenem was not effective. Finally, the patient was confirmed to have Nocardia otitidiscaviarum infection by mass spectrometry. According to the antibiotic sensitivity test and minimum inhibitory concentration (MIC) value results, Nocardia otitidiscaviarum was resistant to imipenem, so the treatment was changed to trimethoprim-sulfamethoxazole combined with linzolid. The patient’s condition improved rapidly and he was discharged after his condition was stable.

Conclusion

This case reminded us that for patients with a history of chronic lung disease, when pulmonary infection occurs during hormone or immunosuppressive therapy for kidney disease, the possibility of Nocardia infection should be fully considered, and high-quality specimens should be collected as early as possible. Appropriate bacterial culture methods and efficient identification techniques should be adopted to promptly identify pathogens, and personalized treatment plans should be developed based on antibiotic sensitivity tests to save patients’ lives.
Comparative growth kinetics and drug susceptibility of Mycobacterium tuberculosis lineages prevalent in Ethiopia: implications for tuberculosis treatment and management
Authors: Hailemariam Tesfaye Gebreyohannis , Tilahun Melaku , Atnafu Abay , Gelanew Tesfaye , Gebresilase Tewodros Tariku , Tola Mekdes Alemu , Ayele Abaysew , Siraj Shewki Moga , Shibeshi Workineh , Bobosha Kidist , Wassie Liya , Hirutu Yonas , Engidawork Ephrem
Published: February 2025

Tuberculosis (TB) remains a global health challenge, with treatment outcomes influenced by the genetic diversity of Mycobacterium tuberculosis (Mtb) strains. This study examines the growth kinetics and drug susceptibility of Mtb strains from different lineages in Ethiopia to understand their impact on disease management. Mtb strains, including sub-lineages 4.1.2.1, 4.2.2.2, 4.6.3, lineages 3 and 7, and the reference strain H37Rv (ATCC 27294), were cultured in liquid 7H9 Middlebrook broth. Growth began on day 6 post-inoculation. Sub-lineage 4.1.2.1 showed rapid exponential growth by day 9, reaching the stationary phase by day 15. Sub-lineage 4.1.2.1 followed by sub-lineage 4.2.2.2 had the highest maximum growth concentration (Cmax), indicating enhanced growth efficiency and adaptive traits that may increase their pathogenicity or resistance to host defenses or anti-TB drugs. To support this observation, the minimum inhibitory concentrations (MIC) for first-line anti-TB drugs were assessed for all the studied Mtb strains using the microdilution broth method. While all strains were susceptible, MIC values varied. Sub-lineages 4.1.2.1 and 4.2.2.2 had MIC values matching WHO’s critical concentrations (except for rifampicin). Lineage 3 showed increased sensitivity to rifampicin, isoniazid, and streptomycin, requiring only half the standard concentration. Lineage 7 also exhibited higher sensitivity to rifampicin and streptomycin. These findings highlight the importance of considering lineage-specific differences in Mtb strains for optimizing treatment regimens and improving TB control strategies, particularly in regions with diverse Mtb populations like Ethiopia.
Identification of disease-specific gut microbial markers in vitiligo
Authors: Dou Yimin , Niu Yi , Shen Hexiao , Wang Lan , Lv Yongling , Liu Suwen , Xie Xiafei , Feng Aiping , Liu Xinxin
Published: February 2025

There is a potential correlation between vitiligo and gut microbiota, although research in this area is currently limited. The research employed high-throughput sequencing of 16S rRNA to examine the gut microbiome in the stool samples of 49 individuals with vitiligo and 49 without the condition. The study encompassed four comparison groups: (1) DI (disease) group vs. HC (healthy control) group; (2) DI_m group (disease group of minors) vs. HC_m group (healthy control group of minors); (3) DI_a group (adult disease group) vs. HC_a group (adult healthy control group); (4) DI_m group vs. DI_a group. Research findings have indicated the presence of spatial heterogeneity in the gut microbiota composition between individuals with vitiligo and healthy controls. A significant reduction in gut microbiota diversity has been observed in vitiligo patients across both minors and adult groups. However, variations have been noted in the composition of disease-related differential microbial markers among different age groups. Specifically, Bacteroides and Parabacteroides have been identified as specific markers of the intestinal microbiota of vitiligo patients in both minor and adult groups. Correlative analyses have revealed a positive correlation of these two genera with the Vitiligo Area Scoring Index (VASI) and disease duration. It is noteworthy that there are no significant differences in diversity between the DI_m group and the DI_a group, with similarities in microbiota composition and functional characteristics. Nevertheless, correlative analyses suggest a declining trend in Bacteroides and Parabacteroides with increasing age. Individuals with vitiligo exhibit distinct features in their gut microbiome when contrasted with those in the healthy control group. Additionally, the microbial marker genera that show variances between patients and healthy controls vary among different age groups. Disease-specific microbial marker genera (Bacteroides and Parabacteroides) are associated with VASI, duration of the condition, and age. These findings are essential for improving early diagnosis and developing potential treatment strategies for individuals with vitiligo.