bluuebunny/crossref_metadata_2025 huggingface dataset:
Probing fast oscillating scalar dark matter with atoms and molecules
Authors: Antypas Dionysios , Tretiak Oleg , Zhang Ke , Garcon Antoine , Perez Gilad , Kozlov Mikhail G. , Schiller Stephan , Budker Dmitry
Published: February 2021

Light scalar dark matter (DM) with scalar couplings to matter is expected within several scenarios to induce variations in the fundamental constants of nature. Such variations can be searched for, among other ways, via atomic spectroscopy. Sensitive atomic observables arise primarily due to possible changes in the fine-structure constant or the electron mass. Most of the searches to date have focused on slow variations of the constants (i.e. modulation frequencies <1 Hz). In a recent experiment (2019 Phys. Rev. Lett.
123 141102) called weekend relaxion-search laboratory (WReSL), we reported on a direct search for rapid variations in the radio-frequency band. Such a search is particularly motivated within a class of relaxion DM models. We discuss the WReSL experiment, report on progress toward improved measurements of rapid fundamental constant variations, and discuss the planned extension of the work to molecules, in which rapid variations of the nuclear mass can be sensitively searched for.
A review: non-antibacterial, non-antifungal and non-anticancer properties of nanoparticles the forgotten paradigm
Authors: Ankamwar (NanoBA) Balaprasad , Yadwade Rachana
Published: February 2021

The review highlights the need of non-antibacterial, non-antifungal and non-anticancer characters of metal or metal oxide nanoparticles. The usage of nanoparticles as a part of therapeutic measures results in certain unfavourable effects. The nanoparticles can disturb healthy gut microorganisms that may bring about some health damages regarding pathogenic diseases, obesity, and inflammation likewise. Even the nonspecific interactions of nanoparticles with healthy cells and tissues can cause altered expressions of various pro-inflammatory factors and stress related genes. This review indicates and prospect about the demand of nanoparticles with non-antibacterial, non-antifungal and non-anticancer properties. Such nanoparticles will be effective in various remedial and diagnostic purposes.
Frequently dense harmonic functions and universal martingales on trees
Authors: Abakumov Evgeny , Nestoridis Vassili , Picardello Massimo
Published: February 2021

On a large class of infinite trees

T
T

, we prove the existence of harmonic functions

h
h

, with respect to suitable transient transition operators

P
P

, that satisfy the following universal property:

h
h

is the Poisson transform of a martingale on the end-point boundary

Ω
\Omega

of

T
T

(equipped with the harmonic measure induced by

P
P

) such that, for every measurable function

f
f

on

Ω
\Omega

, it contains a subsequence converging to

f
f

in measure. Moreover, the martingale visits every open set of measurable functions with positive lower density.
Occludin and tricellulin facilitate formation of anastomosing tight-junction strand network to improve barrier function
Authors: Saito Akira C. , Higashi Tomohito , Fukazawa Yugo , Otani Tetsuhisa , Tauchi Masashi , Higashi Atsuko Y. , Furuse Mikio , Chiba Hideki
Published: February 2021

Tight junctions (TJs) are composed of claudin-based TJ strands. The complexity of TJ strands regulates paracellular permeability of epithelial cells. Occludin and tricellulin contribute to the formation of the complex TJ-strand network possibly by connecting TJ strands and establishment of a tight barrier.
The Long-Term Impact of Adversity in Adolescence on Health in Middle and Older Adulthood: A Natural Experiment From the Chinese Send-Down Movement
Authors: Ye Xin , Zhu Dawei , He Ping
Published: February 2021

The 1950s–1970s Chinese send-down movement can be treated as a natural experiment to study the impact of adolescent exposure on subsequent health. This paper used data from the China Family Panel Studies 2010 to evaluate the long-term impact of the Chinese send-down movement on individual health later in life. Drawing from the life-course perspective, results from difference-in-differences models suggested that the send-down experience had a significant impact on worse self-rated health; the pathways from structural equation models showed that subsequent achievements—age of marriage and educational attainment—had mediating effects linking the send-down experience to worse self-rated health and better mental health, respectively. Taken together, our results highlight the roles of the send-down experience and post–send-down characteristics in shaping health outcomes later in life.
Straight to the point: Experiential punctivism and the perception of time
Authors: Pollock Henry
Published: February 2021

The aim of this paper is to show that the A-theorist's argument from experience is undermined by a commitment to ‘experiential punctivism' - the view that instantaneous (or near-instantaneous) experiences are metaphysically prior to durative ones. The experiences to which the A-theorist's argument appeals are those of processual events. For these experiences to constitute perceptions of temporal passage it would be necessary to perceive such processes qua processes; but, if experiential punctivism were true, this would be impossible. We could only ever perceive those processes qua temporal variation, which merely amounts to an awareness of change as described by the B-theory. If there is such a phenomenon as the passing of time, it could not be an object of our experience.
Habituation or sensitization? Long-term responses of yellow-bellied marmots to human disturbance
Authors: Uchida Kenta , Blumstein Daniel T
Published: February 2021

Continuous exposure to humans causes wildlife to either habituate or sensitize. Although increased tolerance may play an important role in coexistence with humans, the mechanisms and fitness outcomes of long-term changes of tolerance are not fully understood because only a few studies have assessed individual- and population-level responses over many years. We developed a novel predictive framework to study habituation and sensitization to humans and applied it to yellow-bellied marmots (Marmota flaviventer) in areas of high and low human disturbance. We focused on two antipredator behaviors—time allocation to vigilance during foraging to quantify baseline vigilance levels and flight initiation distance (FID)—to quantify subsequent responsiveness to threat. We used the rate of body mass gain during the active season as a fitness outcome. Assessing 15 years’ population and individual-level responses to human disturbances, marmots in highly disturbed colonies allocated more time to vigilance, but this did not change over time. FID decreased on average when they were approached more and also tended to decrease in highly disturbed colonies and over 15 years. Yet, there was individuality in FIDs; marmots that fled at greater distances became sensitized with repeated approaches. Additionally, the marmots in highly disturbed colonies gained less body mass over time compared to conspecifics in less disturbed colonies. These results suggested that, although marmots habituated to humans, long-term human disturbance has negative fitness consequences. Our framework should help wildlife managers evaluate the comprehensive impact of human activities on wildlife.
OpenContami: a web-based application for detecting microbial contaminants in next-generation sequencing data
Authors: Park Sung-Joon , Nakai Kenta
Published: February 2021

Microorganisms infect and contaminate eukaryotic cells during the course of biological experiments. Because microbes influence host cell biology and may therefore lead to erroneous conclusions, a computational platform that facilitates decontamination is indispensable. Recent studies show that next-generation sequencing (NGS) data can be used to identify the presence of exogenous microbial species. Previously, we proposed an algorithm to improve detection of microbes in NGS data. Here, we developed an online application, OpenContami, which allows researchers easy access to the algorithm via interactive web-based interfaces. We have designed the application by incorporating a database comprising analytical results from a large-scale public dataset and data uploaded by users. The database serves as a reference for assessing user data and provides a list of genera detected from negative blank controls as a ‘blacklist’, which is useful for studying human infectious diseases. OpenContami offers a comprehensive overview of exogenous species in NGS datasets; as such, it will increase our understanding of the impact of microbial contamination on biological and pathological traits.

Availability and implementation

OpenContami is freely available at: https://openlooper.hgc.jp/opencontami/.

Supplementary information

Supplementary data are available at Bioinformatics online.
Variation in Pyramidal Cell Morphology Across the Human Anterior Temporal Lobe
Authors: Benavides-Piccione Ruth , Rojo Concepcion , Kastanauskaite Asta , DeFelipe Javier
Published: February 2021

Pyramidal neurons are the most abundant and characteristic neuronal type in the cerebral cortex and their dendritic spines are the main postsynaptic elements of cortical excitatory synapses. Previous studies have shown that pyramidal cell structure differs across layers, cortical areas, and species. However, within the human cortex, the pyramidal dendritic morphology has been quantified in detail in relatively few cortical areas. In the present work, we performed intracellular injections of Lucifer Yellow at several distances from the temporal pole. We found regional differences in pyramidal cell morphology, which showed large inter-individual variability in most of the morphological variables measured. However, some values remained similar in all cases. The smallest and least complex cells in the most posterior temporal region showed the greatest dendritic spine density. Neurons in the temporal pole showed the greatest sizes with the highest number of spines. Layer V cells were larger, more complex, and had a greater number of dendritic spines than those in layer III. The present results suggest that, while some aspects of pyramidal structure are conserved, there are specific variations across cortical regions, and species.
Drifts in Prefrontal and Parietal Neuronal Activity Influence Working Memory Judgments
Authors: Li Sihai , Constantinidis Christos , Qi Xue-Lian
Published: February 2021

The dorsolateral prefrontal cortex (dlPFC) plays a critical role in spatial working memory and its activity predicts behavioral responses in delayed response tasks. Here, we addressed if this predictive ability extends to other working memory tasks and if it is present in other brain areas. We trained monkeys to remember the location of a stimulus and determine whether a second stimulus appeared at the same location or not. Neurophysiological recordings were performed in the dorsolateral prefrontal cortex and posterior parietal cortex (PPC). We hypothesized that random drifts causing the peak activity of the network to move away from the first stimulus location and toward the location of the second stimulus would result in categorical errors. Indeed, for both areas, in nonmatching trials, when the first stimulus appeared in a neuron’s preferred location, the neuron showed significantly higher firing rates in correct than in error trials; and vice versa, when the first stimulus appeared at a nonpreferred location, activity in error trials was higher than in correct. The results indicate that the activity of both dlPFC and PPC neurons is predictive of categorical judgments of information maintained in working memory, and neuronal firing rate deviations are revealing of the contents of working memory.
Recombinant Zoster Vaccine (Shingrix): Real-World Effectiveness in the First 2 Years Post-Licensure
Authors: Izurieta Hector S , Wu Xiyuan , Forshee Richard , Lu Yun , Sung Heng-Ming , Agger Paula Ehrlich , Chillarige Yoganand , Link-Gelles Ruth , Lufkin Bradley , Wernecke Michael , MaCurdy Thomas E , Kelman Jeffrey , Dooling Kathleen
Published: February 2021

Background

Shingrix (recombinant zoster vaccine) was licensed to prevent herpes zoster, dispensed as 2 doses given 2–6 months apart among adults aged ≥50 years. Clinical trials yielded efficacy of >90% for confirmed herpes zoster, but post-market performance has not been evaluated. Efficacy of a single dose and a delayed second dose and efficacy among persons with autoimmune or immunosuppressive conditions have not been studied. We aimed to assess post-market vaccine effectiveness of Shingrix.

Methods

We conducted a cohort study among Medicare Part D community-dwelling beneficiaries aged >65 years. Herpes zoster was identified using a medical office visit diagnosis with treatment, and postherpetic neuralgia was identified using a validated algorithm. We used inverse probability of treatment weighting to improve cohort balance and marginal structural models to estimate hazard ratios.

Results

We found a vaccine effectiveness of 70.1% (95% confidence interval [CI], 68.6–71.5) and 56.9% (95% CI, 55.0–58.8) for 2 and 1 doses, respectively. The 2-dose vaccine effectiveness was not significantly lower for beneficiaries aged >80 years, for second doses received at ≥180 days, or for individuals with autoimmune conditions. The vaccine was also effective among individuals with immunosuppressive conditions. Two-dose vaccine effectiveness against postherpetic neuralgia was 76.0% (95% CI, 68.4–81.8).

Conclusions

This large real-world observational study of the effectiveness of Shingrix demonstrates the benefit of completing the 2-dose regimen. Second doses administered beyond the recommended 6 months did not impair effectiveness. Our effectiveness estimates were lower than the clinical trials estimates, likely due to differences in outcome specificity.
Incidence of Medically Attended Acute Respiratory Illnesses Due to Respiratory Viruses Across the Life Course During the 2018/19 Influenza Season
Authors: Jackson Michael L , Starita Lea , Kiniry Erika , Phillips C Hallie , Wellwood Stacie , Cho Shari , Kiavand Anahita , Truong Melissa , Han Peter , Richardson Matthew , Wolf Caitlin R , Heimonen Jessica , Nickerson Deborah A , Chu Helen Y ,   Seattle Flu Study Investigators, Chu Helen Y , Boeckh Michael , Englund Janet A , Famulare Michael , Lutz Barry R , Nickerson Deborah A , Rieder Mark J , Starita Lea M , Thompson Matthew , Shendure Jay , Bedford Trevor , Adler Amanda , Brandstetter Elisabeth , Bosua Jeris , Cho Shari , Frazar Chris D , Han Peter D , Gulati Reena K , Hadfield James , Huang Shichu , Jackson Michael L , Kiavand Anahita , Kimball Louise E , Lacombe Kirsten , Logue Jennifer K , Lyon Victoria , Newman Kira L , Sibley Thomas R , Zigman Suchsland Monica L , Truong Melissa , Wolf Caitlin R
Published: February 2021

Background

Although multiple respiratory viruses circulate in humans, few studies have compared the incidence of different viruses across the life course. We estimated the incidence of outpatient illness due to 12 different viruses during November 2018 through April 2019 in a fully enumerated population.

Methods

We conducted active surveillance for ambulatory care visits for acute respiratory illness (ARI) among members of Kaiser Permanente Washington (KPWA). Enrolled patients provided respiratory swab specimens which were tested for 12 respiratory viruses using reverse transcription polymerase chain reaction (RT-PCR). We estimated the cumulative incidence of infection due to each virus overall and by age group.

Results

The KPWA population under surveillance included 202 562 individuals, of whom 2767 (1.4%) were enrolled in the study. Influenza A(H3N2) was the most commonly detected virus, with an overall incidence of 21 medically attended illnesses per 1000 population; the next most common viruses were influenza A(H1N1) (18 per 1000), coronaviruses (13 per 1000), respiratory syncytial virus (RSV, 13 per 1000), and rhinovirus (9 per 1000). RSV was the most common cause of medically attended ARI among children aged 1–4 years; coronaviruses were the most common among adults aged ≥65 years.

Conclusions

Consistent with other studies focused on single viruses, we found that influenza and RSV were major causes of acute respiratory illness in persons of all ages. In comparison, coronaviruses and rhinovirus were also important pathogens. Prior to the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), coronaviruses were the second-most common cause of medically attended ARI during the 2018/19 influenza season.
Sexually Transmitted Infection Testing Among Transgender Women Living with Human Immunodeficiency Virus in the United States: Medical Monitoring Project, 2015–2019
Authors: Town Katy , Tie Yunfeng , Dasgupta Sharoda , Kirkcaldy Robert D , Crim Stacy M , Weiser John , Bernstein Kyle
Published: February 2021

National guidelines recommend annual sexually transmitted infection testing for sexually active people living with human immunodeficiency virus, including transgender women. Using data from the US Medical Monitoring Project during 2015–2019, in the previous 12 months, 63.3% of sexually active transgender women who were human immunodeficiency virus positive were tested for syphilis, 56.6% for chlamydia, and 54.4% for gonorrhea.
Antibacterial Resistance Leadership Group 2.0: Back to Business
Authors: Chambers Henry F , Evans Scott R , Patel Robin , Cross Heather R , Harris Anthony D , Doi Yohei , Boucher Helen W , van Duin David , Tsalik Ephraim L , Holland Thomas L , Pettigrew Melinda M , Tamma Pranita D , Hodges Kathryn R , Souli Maria , Fowler Vance G
Published: February 2021

In December 2019, the Antibacterial Resistance Leadership Group (ARLG) was awarded funding for another 7-year cycle to support a clinical research network on antibacterial resistance. ARLG 2.0 has 3 overarching research priorities: infections caused by antibiotic-resistant (AR) gram-negative bacteria, infections caused by AR gram-positive bacteria, and diagnostic tests to optimize use of antibiotics. To support the next generation of AR researchers, the ARLG offers 3 mentoring opportunities: the ARLG Fellowship, Early Stage Investigator seed grants, and the Trialists in Training Program. The purpose of this article is to update the scientific community on the progress made in the original funding period and to encourage submission of clinical research that addresses 1 or more of the research priority areas of ARLG 2.0.
The ASL-LEX 2.0 Project: A Database of Lexical and Phonological Properties for 2,723 Signs in American Sign Language
Authors: Sehyr Zed Sevcikova , Caselli Naomi , Cohen-Goldberg Ariel M , Emmorey Karen
Published: February 2021

ASL-LEX is a publicly available, large-scale lexical database for American Sign Language (ASL). We report on the expanded database (ASL-LEX 2.0) that contains 2,723 ASL signs. For each sign, ASL-LEX now includes a more detailed phonological description, phonological density and complexity measures, frequency ratings (from deaf signers), iconicity ratings (from hearing non-signers and deaf signers), transparency (“guessability”) ratings (from non-signers), sign and videoclip durations, lexical class, and more. We document the steps used to create ASL-LEX 2.0 and describe the distributional characteristics for sign properties across the lexicon and examine the relationships among lexical and phonological properties of signs. Correlation analyses revealed that frequent signs were less iconic and phonologically simpler than infrequent signs and iconic signs tended to be phonologically simpler than less iconic signs. The complete ASL-LEX dataset and supplementary materials are available at https://osf.io/zpha4/ and an interactive visualization of the entire lexicon can be accessed on the ASL-LEX page: http://asl-lex.org/.
Effects of Starvation, Age, and Mating Status on Flight Capacity of Laboratory-Reared Brown Marmorated Stink Bug (Hemiptera: Pentatomidae)
Authors: Aita Rafael Carlesso , Kees Aubree M , Aukema Brian H , Hutchison W D , Koch Robert L
Published: February 2021

The brown marmorated stink bug, Halyomorpha halys (Stål) (Hemiptera: Pentatomidae), is an invasive species to North America and has spread throughout most of the territory. Understanding flight in H. halys is crucial to understanding the dispersal capacity and developing forecasting models for this pest. The purpose of this research was to assess the effects of starvation, age, mating status, sex, and preflight weight on flight parameters of laboratory-reared H. halys using computer-monitored flight mills. The mean flight distance observed over a 24-h period was 266 m and the maximum distance was 7.3 km. Overall, the flight capacity of males and females was similar, even though females weighed more than males. The proportion of H. halys that initiated flight was not affected by starvation, age, or mating status. The number of bouts of individual flights and velocity significantly increased with longer durations of starvation. The number of bouts significantly decreased with increasing age. The total distance flew and total flight time was not affected by starvation, age, or mating status. Although some statistical differences were seen across the experiments, these differences likely represent minimal ecological significance. Therefore, these results suggest that H. halys are remarkably resilient, which may contribute to their success as an invasive species. The findings of this study could help better predict the dispersal potential of H. halys in Minnesota.
Self-learning growth simulator for modelling forest stand dynamics in changing conditions
Authors: Pukkala Timo , Vauhkonen Jari , Korhonen Kari T , Packalen Tuula
Published: February 2021

Finnish forest structures vary from even-aged planted forests to two- and multi-storied mixed stands. Also, the range of silvicultural systems in use has increased because thinning from above and continuous cover management are gaining popularity. The data currently available for modelling stand dynamics are insufficient to allow the development of unbiased and reliable models for the simulation of all possible transitions between various current and future stand conditions. Therefore, the models should allow temporal and regional calibration along the accumulation of new information on forest development. If the calibration process is automated, the simulators that use these models constitute a self-learning system that adapts to the properties of new data on stand dynamics. The current study first developed such a model set for stand dynamics that is technically suitable for simulating the stand development in all stand structures, silvicultural systems and their transitions. The model set consists of individual-tree models for diameter increment and survival and a stand-level model for ingrowth. The models were based on the permanent sample plots of the 10th and 11th national forest inventories of Finland. Second, a system for calibrating the models based on additional data was presented. This optimization-based system allows different types and degrees of calibration, depending on the intended use of the models and the amount of data available for calibration. The calibration method was demonstrated with two external datasets where a set of sample plots had been measured two times at varying measurement intervals.
Development of a salutogenic intervention for healthy eating among Dutch type 2 diabetes mellitus patients
Authors: Polhuis Kristel C M M , Vaandrager Lenneke , Soedamah-Muthu Sabita S , Koelen Maria A
Published: February 2021

Lay Summary

Healthy eating can be challenging for type 2 diabetes mellitus (T2DM) patients. The theory of salutogenesis, which focuses on the resources required to organize behavioural changes in everyday life, was used to develop an intervention for healthy eating. The aim was to describe the development, structure and content of this salutogenic intervention. The development consisted of two phases that were based on the operationalization of important key principles of salutogenesis. In Phase 1 (Exploration and synthesis), a systematic review and three qualitative studies were performed to explore important characteristics to enable healthy eating in everyday life. The results were used to develop the draft intervention. In Phase 2 (Validation and adjustment), interviews and workshops were conducted with T2DM patients, healthcare providers and scientists. Based on this, the draft intervention was modified into its final form. The developmental process resulted in a 12-week, group-based intervention that aimed to enable important resources for healthy eating via self-examination, reflection, setting goals and sharing experiences. Attention was also paid to disease information, disease acceptance, food literacy, stress management, self-identity and social support. The group sessions began following an individual intake session, with a booster session held 3 months after the intervention. The researcher’s translation of the stakeholders’ priorities into an intervention was corrected for and approved by the stakeholders concerned. This comprehensive salutogenic intervention was developed based on practical and scientific evidence. Providing transparency in developmental processes and content is important because it determines the scientific integrity and credibility of an intervention.
Predicting play calls in the National Football League using hidden Markov models
Authors: Ötting Marius
Published: February 2021

In recent years, data-driven approaches have become a popular tool in a variety of sports to gain an advantage by, for example, analysing potential strategies of opponents. Whereas the availability of play-by-play or player tracking data in sports such as basketball and baseball has led to an increase of sports analytics studies, equivalent data sets for the National Football League (NFL) were not freely available for a long time. In this contribution, we consider a comprehensive play-by-play NFL dataset provided by www.kaggle.com, comprising 289,191 observations in total, to predict play calls in the NFL using hidden Markov models. The resulting out-of-sample prediction accuracy for the 2018 NFL season is 71.6%, which is similar compared to existing studies on play call predictions in the NFL. In practice, such predictions are helpful for NFL teams, especially for defense coordinators, to make adjustments in real time on the field.
Geometry and Automorphisms of Non-Kähler Holomorphic Symplectic Manifolds
Authors: Bogomolov Fedor , Kurnosov Nikon , Kuznetsova Alexandra , Yasinsky Egor
Published: February 2021

We consider the only one known class of non-Kähler irreducible holomorphic symplectic manifolds, described in the works by D. Guan and the 1st author. Any such manifold $Q$ of dimension $2n-2$ is obtained as a finite degree $n^2$ cover of some non-Kähler manifold $W_F$, which we call the base of $Q$. We show that the algebraic reduction of $Q$ and its base is the projective space of dimension $n-1$. Besides, we give a partial classification of submanifolds in $Q$, describe the degeneracy locus of its algebraic reduction and prove that the automorphism group of $Q$ satisfies the Jordan property.
Meeting the challenge: Health information technology’s essential role in achieving precision medicine
Authors: Zayas-Cabán Teresa , Chaney Kevin J , Rogers Courtney C , Denny Joshua C , White P. Jon
Published: February 2021

Precision medicine can revolutionize health care by tailoring treatments to individual patient needs. Advancing precision medicine requires evidence development through research that combines needed data, including clinical data, at an unprecedented scale. Widespread adoption of health information technology (IT) has made digital clinical data broadly available. These data and information systems must evolve to support precision medicine research and delivery. Specifically, relevant health IT data, infrastructure, clinical integration, and policy needs must be addressed. This article outlines those needs and describes work the Office of the National Coordinator for Health Information Technology is leading to improve health IT through pilot projects and standards and policy development. The Office of the National Coordinator for Health Information Technology will build on these efforts and continue to coordinate with other key stakeholders to achieve the vision of precision medicine. Advancement of precision medicine will require ongoing, collaborative health IT policy and technical initiatives that advance discovery and transform healthcare delivery.
Identification of social determinants of health using multi-label classification of electronic health record clinical notes
Authors: Stemerman Rachel , Arguello Jaime , Brice Jane , Krishnamurthy Ashok , Houston Mary , Kitzmiller Rebecca
Published: February 2021

Objectives

Social determinants of health (SDH), key contributors to health, are rarely systematically measured and collected in the electronic health record (EHR). We investigate how to leverage clinical notes using novel applications of multi-label learning (MLL) to classify SDH in mental health and substance use disorder patients who frequent the emergency department.

Methods and Materials

We labeled a gold-standard corpus of EHR clinical note sentences (N = 4063) with 6 identified SDH-related domains recommended by the Institute of Medicine for inclusion in the EHR. We then trained 5 classification models: linear-Support Vector Machine, K-Nearest Neighbors, Random Forest, XGBoost, and bidirectional Long Short-Term Memory (BI-LSTM). We adopted 5 common evaluation measures: accuracy, average precision–recall (AP), area under the curve receiver operating characteristic (AUC-ROC), Hamming loss, and log loss to compare the performance of different methods for MLL classification using the F1 score as the primary evaluation metric.

Results

Our results suggested that, overall, BI-LSTM outperformed the other classification models in terms of AUC-ROC (93.9), AP (0.76), and Hamming loss (0.12). The AUC-ROC values of MLL models of SDH related domains varied between (0.59–1.0). We found that 44.6% of our study population (N = 1119) had at least one positive documentation of SDH.

Discussion and Conclusion

The proposed approach of training an MLL model on an SDH rich data source can produce a high performing classifier using only unstructured clinical notes. We also provide evidence that model performance is associated with lexical diversity by health professionals and the auto-generation of clinical note sentences to document SDH.
Identification of Reticulitermes Subterranean Termites (Blattodea: Rhinotermitidae) in the Eastern United States Using Inter-Simple Sequence Repeats
Authors: Janowiecki M A , Austin J W , Szalanski A L , Vargo E L
Published: February 2021

In the eastern United States, there are nine species of subterranean termites in three genera: Reticulitermes (six species), Coptotermes (two species), and Prorhinotermes (one species). These species serve as important ecological players by decomposing cellulose material, and some are important structural pests. Many of these species are difficult to discriminate morphologically and require examining the reproductive or soldier castes, which can be difficult to collect. While some genetic tools have been developed for species identification, they are often expensive and time-consuming. To help facilitate identification, we developed a more cost-effective and rapid genetic method to identify Reticulitermes species by screening 10 PCR primers that amplified inter-simple sequence repeats (ISSRs) in other termite species. From these, one primer was amplified in all five focal Reticulitermes species and contained conserved, species-specific fragments. We further screened this identification method on samples of each species covering a diversity of mitochondrial DNA haplotypes and localities. This identification method utilizing ISSRs can be used to quickly identify five species of Reticulitermes subterranean termites in the eastern United States in a matter of hours, providing a useful technique for pest management as well as future ecological research.
The Behavioral Elasticity of Tax Revenue
Authors: Hemel Daniel J , Weisbach David A
Published: February 2021

This article presents a measure of the efficiency consequences of changes to tax policies that inform a wide range of tax law debates. Building upon recent extensions to the “elasticity of taxable income” concept, we clarify the relationship among revenue effects, administrative costs, and compliance costs. The resulting measure—the behavioral elasticity of tax revenue (BETR)—captures the change in total resources resulting from marginal changes in tax rates, the tax base, or tax enforcement. We illustrate the BETR’s utility through a series of case studies. We also show how the BETR can help policy makers select more efficient redistributive mechanisms.
Minor modification of frequency modulated call parameters underlies a shift in behavioral response in the Great Himalayan leaf-nosed bats, Hipposideros armiger
Authors: Zhang Chunmian , Sun Congnan , Wang Zhiqiang , Lin Peichen , Xiao Yanhong , Metzner Walter , Feng Jiang , Jiang Tinglei
Published: February 2021

Different categories of social calls may be used in a variety of behavioral contexts and may have different functions. Here, we show that Great Himalayan leaf-nosed bats emit two types of calls: bent upward frequency modulated (bUFM) calls emitted during agonistic interactions between two bats that have perched close to each other and stepped upward frequency modulated (sUFM) calls emitted by a roosting individual when a free-flying bat approached. There were significant differences in acoustic parameters between bUFM calls and sUFM calls. Moreover, we tested different choices of Hipposideros armiger to playback of bUFM calls and sUFM calls. The bats avoided the location of bUFM call playbacks independent of the simultaneous playback of echolocation pulses, silence, or sUFM calls. The bats also avoided approaching the side of the flight room where sUFM calls were broadcast when also presented with playbacks of echolocation pulses, but not when simultaneously presented with silence. The results suggest that bUFM calls may serve the function of territorial defense, while sUFM calls may convey warning information. Our results, therefore, imply that the two types of calls have different functions depending on behavioral context. These differences in function suggest that bats can detect context-dependent modifications of acoustic cues across the two types of social calls.
Tracking The Price of Almonds in Spain
Authors: Martínez-Sánchez Francisco
Published: February 2021

I look for signs of manipulation of the price of almonds in the markets of Albacete, Murcia, and Reus in Spain. To that end, I use Benford’s Law to analyze the distribution of the second and third digits of the price of almonds. I find that prices in the Albacete and Reus markets deviate from Benford’s Law, especially for the third digit, and those in the Murcia market deviate from Benford’s Law for the second digit but not for the third digit. I therefore find signs that the price of almonds in the Spain’s main markets is being manipulated.
Comparative bioavailability of curcuminoids from a water-dispersible high curcuminoid turmeric extract against a generic turmeric extract: a randomized, cross-over, comparative, pharmacokinetic study
Authors: Thanawala Shefali , Shah Rajat , Alluri KrishnaRaju Venkata , Somepalli Venkateswarlu , Vaze Sanjay , Upadhyay Vivek
Published: February 2021

Objectives

The therapeutic utility of turmeric (Curcuma longa L., Zingiberaceae) is limited due to low bioavailability of its active principal curcuminoids. This study evaluates the pharmacokinetic characteristics of a natural, water-dispersible turmeric extract containing 60% curcuminoids (TurmXtra 60N), referred to as WDTE60N, compared to standard turmeric extract 95% (STE95).

Methods

This open-label, two-way crossover, single oral dose, comparative pharmacokinetic study, randomized 14 subjects to receive one capsule of WDTE60N (150 mg curcuminoids) or three capsules of STE95 (500 mg curcuminoids each). The resulting dose ratio of actives for WDTE60N:STE95 was 1:10.

Key findings

Peak plasma levels of free curcumin, total curcuminoids, tetrahydrocurcumin and demethoxycurcumin were similar (P > 0.05). Cmax of total curcumin was higher (P = 0.0253) for WDTE60N at a 10-fold lower dose compared to STE95 (43.5 ± 28.5 vs. 21.3 ± 10.7 ng/ml). Mean AUC0-t was higher (P < 0.001) for free curcumin and comparable for total curcumin and total curcuminoids with WDTE60N than with STE95. Five adverse events were reported in three subjects (mild in severity) and were unrelated to study products.

Conclusion

WDTE60N showed higher absorption and comparable exposure for free curcumin, total curcumin and total curcuminoids at a 10-fold lower dose than STE95.
Sucrose transport and metabolism control carbon partitioning between stem and grain in rice
Authors: Mathan Jyotirmaya , Singh Anuradha , Ranjan Aashish
Published: February 2021

Source–sink relationships are key to overall crop performance. Detailed understanding of the factors that determine source–sink dynamics is imperative for the balance of biomass and grain yield in crop plants. We investigated the differences in source–sink relationships between a cultivated rice, Oryza sativa cv. Nipponbare, and a wild rice, Oryza australiensis, which show striking differences in biomass and grain yield. Oryza australiensis, which accumulates a higher biomass, not only showed higher photosynthesis per unit leaf area but also exported more sucrose from leaves compared with Nipponbare. However, grain features and sugar content suggested limited sucrose mobilization to grains in the wild rice due to vasculature and sucrose transporter functions. Low cell wall invertase activity and high sucrose synthase cleavage activity followed by higher expression of cellulose synthase genes in O. australiensis stem indicated that it utilized photosynthates preferentially for the synthesis of structural carbohydrates, resulting in high biomass. In contrast, source–sink relationships favored high grain yield in Nipponbare via accumulation of transitory starch in the stem, due to higher expression of starch biosynthetic genes, which is mobilized to panicles at the grain filling stage. Thus, vascular features, sucrose transport, and functions of sugar metabolic enzymes explained the differences in source–sink relationships between Nipponbare and O. australiensis.
Flip mechanism of Jupiter-crossing orbits in the non-hierarchical triple system
Authors: Li Miao , Lei Hanlun , Huang Yukun , Gong Shengping
Published: February 2021

With the discovery of more and more retrograde minor bodies, retrograde orbits’ production mechanism has attracted much attention. However, almost all of the current research on the flip mechanism is based on the hierarchical approximation. In this paper, we study the flip mechanism of Jupiter-crossing orbits in a non-hierarchical Sun–Jupiter triple system. Numerical experiments summarize the characteristics of flipping orbits, and this provides essential guidance for the semi-analytical method. The i − Ω portraits of flipping particles are obtained and verified by numerical integrations. Based on the previous numerical experiments, 200 000 test particles in a particular range are generated and integrated over 1 Myr. The flip region on the entire a − e parameter space is obtained. For each grid of the flip area, we plot the i − Ω portrait and measure the corresponding Jupiter’s flip ability. The gaps around the mean motion resonances (MMRs) in the flip region are also investigated. The MMRs protect the particles in these gaps from flips. Different resonant widths cause the differences in the size of these gaps. The flip mechanism is systematically studied in a planet-crossing system. The complete map of Jupiter’s flip ability in the entire flip region is depicted. Given the orbital parameters of the particle, we can assess whether the flip will occur in Jupiter’s presence. Our work can also apply to build the flip maps of other massive planets. And it may help understand the evolution of retrograde minor bodies.
Resolved H i in two ultra-diffuse galaxies from contrasting non-cluster environments
Authors: Scott T C , Sengupta Chandreyee , Lagos P , Chung Aeree , Wong O Ivy
Published: February 2021

We report on the first resolved H i observations of two blue ultra-diffuse galaxies (UDGs), using the Giant Metrewave Radio Telescope (GMRT). These observations add to the so-far limited number of UDGs with resolved H i data. The targets are from contrasting non-cluster environments: UDG-B1 is projected in the outskirts of Hickson Compact Group 25 and Secco-dI-2 (SdI-2) is an isolated UDG. These UDGs also have contrasting effective radii with Re of 3.7 kpc (similar to the Milky Way) and 1.3 kpc, respectively. SdI-2 has an unusually large $\frac{M_{\rm H\,{\small I}}}{M_*}$ ratio  = 28.9, confirming a previous single dish H i observation. Both galaxies display H i morphological and kinematic signatures consistent with a recent tidal interaction, which is also supported by observations from other wavelengths, including optical spectroscopy. Within the limits of the observations’ resolution our analysis indicates that SdI-2 is dark matter dominated within its H i radius and this is also likely to be the case for UDG-B1. Our study highlights the importance of high spatial and spectral resolution H i observations for the study of the dark matter properties of UDGs.
Equilibrium sequences of differentially rotating stars with post-merger-like rotational profiles
Authors: Iosif Panagiotis , Stergioulas Nikolaos
Published: February 2021

We present equilibrium sequences of rotating relativistic stars, constructed with a new rotation law that was proposed by Uryū et al. (2017). We choose rotational parameters motivated by simulations of binary neutron star merger remnants, but otherwise adopt a cold, relativistic N = 1 polytropic EOS, in order to perform a detailed comparison to published equilibrium sequences that used the Komatsu, Eriguchi and Hachisu (1989) rotation law. We find a small influence of the choice of rotation law on the mass of the equilibrium models and a somewhat larger influence on their radius. The versatility of the new rotation law allows us to construct models that have a similar rotational profile and axial ratio as observed for merger remnants, while at the same time being quasi-spherical. More specifically, we construct equilibrium sequence variations with different degrees of differential rotation and identify type A and type C solutions, similar to the corresponding types in the classification of Ansorg, Gondek-Rosińska and Villain (2009). While our models are highly accurate solutions of the fully general relativistic structure equations, we demonstrate that for models relevant to merger remnants the IWM-CFC approximation still maintains an acceptable accuracy.
Mechanisms of spacer acquisition by sequential assembly of the adaptation module in Synechocystis
Authors: Wu Chengyong , Tang Dongmei , Cheng Jie , Hu Daojun , Yang Zejing , Ma Xue , He Haihuai , Yao Shaohua , Fu Tian-Min , Yu Yamei , Chen Qiang
Published: February 2021

CRISPR–Cas immune systems process and integrate short fragments of DNA from new invaders as spacers into the host CRISPR locus to establish molecular memory of prior infection, which is also known as adaptation in the field. Some CRISPR–Cas systems rely on Cas1 and Cas2 to complete the adaptation process, which has been characterized in a few systems. In contrast, many other CRISPR–Cas systems require an additional factor of Cas4 for efficient adaptation, the mechanism of which remains less understood. Here we present biochemical reconstitution of the Synechocystis sp. PCC6803 type I-D adaptation system, X-ray crystal structures of Cas1–Cas2–prespacer complexes, and negative stained electron microscopy structure of the Cas4–Cas1 complex. Cas4 and Cas2 compete with each other to interact with Cas1. In the absence of prespacer, Cas4 but not Cas2 assembles with Cas1 into a very stable complex for processing the prespacer. Strikingly, the Cas1-prespacer complex develops a higher binding affinity toward Cas2 to form the Cas1–Cas2–prespacer ternary complex for integration. Together, we show a two-step sequential assembly mechanism for the type I-D adaptation module of Synechocystis, in which Cas4–Cas1 and Cas1–Cas2 function as two exclusive complexes for prespacer processing, capture, and integration.
Molecular design revitalizes the low-cost PTV-polymer for highly efficient organic solar cells
Authors: Ren Junzhen , Bi Pengqing , Zhang Jianqi , Liu Jiao , Wang Jingwen , Xu Ye , Wei Zhixiang , Zhang Shaoqing , Hou Jianhui
Published: February 2021

Developing photovoltaic materials with simple chemical structures and easy synthesis still remains a major challenge in the industrialization process of organic solar cells (OSCs). Herein, an ester substituted poly(thiophene vinylene) derivative, PTVT-T, was designed and synthesized in very few steps by adopting commercially available raw materials. The ester groups on the thiophene units enable PTVT-T to have a planar and stable conformation. Moreover, PTVT-T presents a wide absorption band and strong aggregation effect in solution, which are the key characteristics needed to realize high performance in non-fullerene-acceptor (NFA)-based OSCs. We then prepared OSCs by blending PTVT-T with three representative fullerene- and NF-based acceptors, PC71BM, IT-4F and BTP-eC9. It was found that PTVT-T can work well with all the acceptors, showing great potential to match new emerging NFAs. Particularly, a remarkable power conversion efficiency of 16.20% is achieved in a PTVT-T:BTP-eC9-based device, which is the highest value among the counterparts based on PTV derivatives. This work demonstrates that PTVT-T shows great potential for the future commercialization of OSCs.
Fatal FrontierTemporal and Spatial Considerations of the Native Mounted Police and Colonial Violence Across Queensland
Authors: Wallis Lynley A. , Burke Heather , Barker Bryce , Cole Noelene
Published: February 2021

Over the past two decades, archaeologists have explored aspects of Indigenous agency to better encompass experiences of cross-cultural contact in colonial Australia. Yet the area of frontier conflict has largely remained the purview of historians, in part because of challenges in identifying such events archaeologically. One alternative means through which to consider frontier conflict is to investigate the material remains of colonial policing forces. This article focuses on the camps of the Native Mounted Police, a paramilitary government force that operated in Queensland from 1849 (before the state was officially established) until the early decades of the twentieth century. During this period, this force variously occupied 174 camp sites across Queensland, spread unevenly across pastoral and biogeographic districts. By mapping known events of frontier conflict (whether they be attacks on Aboriginal or non-Aboriginal people, stock, and/or property) across the state, we demonstrate that the extent and nature of frontier conflict was highly variable spatially and temporally, and was tied into a largely negative feedback loop with the deployment of the Native Mounted Police. Although Native Mounted Police camps did not form a defensive cordon of structures akin to a ‘frontier line’ across Queensland, they demarcated a frontier ‘zone’ that was contested, precarious, and violent. The fact that so many camps were required for such a long period provides clear evidence of the persistent and determined resistance of Aboriginal peoples to the theft of their land and the bloodshed that resulted.