bluuebunny/crossref_metadata_2025 huggingface dataset:
Figure 3 from BRCA Status Dictates Wnt Responsiveness in Epithelial Ovarian Cancer
Authors: Chehade Hussein , Gogoi Radhika , Adzibolosu Nicholas K. , Galoforo Sandra , Fehmi Rouba-Ali , Kheil Mira , Fox Alexandra , Kim Seongho , Rattan Ramandeep , Hou Zhanjun , Morris Robert T. , Matherly Larry H. , Mor Gil , Alvero Ayesha B.
Published: August 2024

Characterization of the Wnt signaling pathway in isogenic mouse ovarian cancer cells upon loss of Brca1 or Brca2. Cellular fractionation was performed to separate cytoplasmic (A) and nuclear (B) fractions in control no-treatment cells or cells treated with 100 ng/mL Wnt3A for 8 hours; ILF3 and Cox-IV were used as integrity controls for nuclear and cytoplasmic fractions, respectively. C, Levels and cellular location of β-catenin were determined by immunofluorescence for β-catenin (green). DAPI nuclear staining is shown in blue. Images show both green and DAPI channels; white arrows show increased green staining in the nucleus after Wnt3A treatment in ID8Trp53−/−; the red arrow shows increased green staining in the cytoplasm after Wnt3A treatment in ID8Trp53−/−;Brca1−/−; yellow arrows show membranal staining in ID8Trp53−/−;Brca2−/−; images shown are specific foci in the cultures. D, Levels of canonical Wnt/β-catenin gene targets were determined by Western blot analysis using whole-cell lysates. The red box shows truncated forms of Tcf1/7. DAPI, 4′,6′-diamidino-2-phenylindole.
Figure 2 from mTORC1-Driven Protein Translation Correlates with Clinical Benefit of Capivasertib within a Genetically Preselected Cohort of PIK3CA-Altered Tumors
Authors: Sobsey Constance A. , Froehlich Bjoern C. , Mitsa Georgia , Ibrahim Sahar , Popp Robert , Zahedi Rene P. , de Bruin Elza C. , Borchers Christoph H. , Batist Gerald
Published: August 2024

Mapping of global proteomics results from CB vs. NCB groups to protein networks and pathways. A, Network analysis via String-DB plot of high-confidence protein–protein interactions among proteins that are significantly different between CB and NCB group. Edges represent lines of evidence of protein–protein interactions. Line colors indicate different evidence types: known interactions from curated databases (teal) or published experiments (pink), predicted interactions based on gene location (green), fusion (red), or co-occurrence (blue), or observed co-expression (black), protein homology (purple), or textmining relationships (lime). Major clusters are labeled according to shared features within the cluster. Nodes are overlaid from the Cytoscape visualization, with fold-change shown by color. Node size increases as the P-value decreases. B, Top 20 canonical pathways that are significantly differentially activated between clinical benefit (CB) and no clinical benefit (NCB) groups, based on assessment with Fisher’s exact test in Qiagen IPA. The height of the bar corresponds to the confidence of an association, with a threshold of P < 0.01. IPA’s Z-score indicates the direction of regulation and extreme z-scores are depicted with increased color intensity. Orange bars represent increased activation in the NCB group whereas blue bars represent upregulated activity in the CB group. White bars indicate pathways with fewer than four mapped proteins or z-scores close to zero, indicating that the direction of regulation of individual pathway members does not strongly match a prespecified pattern. Gray bars indicate pathways for which no prediction can be made due to available evidence in the database.
Figure 2 from BRCA Status Dictates Wnt Responsiveness in Epithelial Ovarian Cancer
Authors: Chehade Hussein , Gogoi Radhika , Adzibolosu Nicholas K. , Galoforo Sandra , Fehmi Rouba-Ali , Kheil Mira , Fox Alexandra , Kim Seongho , Rattan Ramandeep , Hou Zhanjun , Morris Robert T. , Matherly Larry H. , Mor Gil , Alvero Ayesha B.
Published: August 2024

Wnt signaling is predicted to be inhibited in BRCA2mt ovarian tumors. A, DEGs comparing BRCA2mt vs. BRCA1mt and (B) BRCA2mt vs. HRwt reported as logFC; red bars represent upregulated, and blue bars represent downregulated; note that several Wnt inhibitors are upregulated in BRCA2mt tumors (red asterisk). C, Perturbation analysis of the Wnt signaling pathway comparing BRCA2mt and BRCA1mt tumors; red genes are predicted to be upregulated, and blue genes are predicted to be downregulated; the dashed circle shows β-catenin is predicted to be downregulated. Red arrows indicate upregulation of several Wnt signaling inhibitors at the level of the receptor.
Data from BRCA Status Dictates Wnt Responsiveness in Epithelial Ovarian Cancer
Authors: Chehade Hussein , Gogoi Radhika , Adzibolosu Nicholas K. , Galoforo Sandra , Fehmi Rouba-Ali , Kheil Mira , Fox Alexandra , Kim Seongho , Rattan Ramandeep , Hou Zhanjun , Morris Robert T. , Matherly Larry H. , Mor Gil , Alvero Ayesha B.
Published: August 2024

Abstract
The association of BRCA1 and BRCA2 mutations with increased risk for developing epithelial ovarian cancer is well established. However, the observed clinical differences, particularly the improved therapy response and patient survival in BRCA2-mutant patients, are unexplained. Our objective is to identify molecular pathways that are differentially regulated upon the loss of BRCA1 and BRCA2 functions in ovarian cancer. Transcriptomic and pathway analyses comparing BRCA1-mutant, BRCA2-mutant, and homologous recombination wild-type ovarian tumors showed differential regulation of the Wnt/β-catenin pathway. Using Wnt3A-treated BRCA1/2 wild-type, BRCA1-null, and BRCA2-null mouse ovarian cancer cells, we observed preferential activation of canonical Wnt/β-catenin signaling in BRCA1/2 wild-type ovarian cancer cells, whereas noncanonical Wnt/β-catenin signaling was preferentially activated in the BRCA1-null ovarian cancer cells. Interestingly, BRCA2-null mouse ovarian cancer cells demonstrated a unique response to Wnt3A with the preferential upregulation of the Wnt signaling inhibitor Axin2. In addition, decreased phosphorylation and enhanced stability of β-catenin were observed in BRCA2-null mouse ovarian cancer cells, which correlated with increased inhibitory phosphorylation on GSK3β. These findings open venues for the translation of these molecular observations into modalities that can impact patient survival.
Significance:
We show that BRCA1 and BRCA2 mutation statuses differentially impact the regulation of the Wnt/β-catenin signaling pathway, a major effector of cancer initiation and progression. Our findings provide a better understanding of molecular mechanisms that promote the known differential clinical profile in these patient populations.
NF2-Related Schwannomatosis Exhibiting the Complete Constellation of Multiple Inherited Schwannomas, Meningiomas, and Ependymomas (MISME Syndrome)
Authors: Pedregosa II Bonifacio , Ramos Mark , Villaraza Steven
Published: August 2024

Introduction: NF2-related schwannomatosis (NF2) is a rare inheritable autosomal dominant disorder characterized by multiple nervous system neoplasms. Case Presentation: In this report, we present a rare case of NF2 exhibiting the complete constellation of multiple inherited schwannomas, meningiomas, and ependymomas (MISME syndrome). Conclusion: This is the first documented case of simultaneous occurrence of all three tumors in a single patient in the Philippines, adding to the sparse evidence of MISME syndrome in world literature.
Giant Cell Tumor of Flexor Tendon Sheath: An Interesting Clinical Presentation as Subungual Growth
Authors: Grover Chander , Gupta Pratibha , Arora Rajesh , Jain Pragya
Published: August 2024

Introduction: Giant cell tumor of tendon sheath (GCTTS), presenting as a subungual mass, is a diagnostic challenge and requires differentiation from other subungual tumors such as fibroma of tendon sheath and superficial acral fibromyxoma. Case Report: We describe a 32-year-old female patient with a relatively rare subungual presentation of GCTTS. The patient presented with slowly enlarging, painless subungual swelling over the dorsum of the right thumb, raising the proximo-lateral nail plate, extending under the proximal nail fold. The clinical, onychoscopic, radiological, and histopathological features of the case are described, which helped in confirmation of diagnosis and differentiation from other subungual tumors. Conclusion: GCTTS can present as a diagnostic challenge due to its varied clinical manifestations, especially in the subungual location. A combination of clinical features and onychoscopy can point toward a diagnosis, which can be confirmed upon excision and histopathology.
Screening and Characterization of a Chryseobacterium timonianum Strain with Aflatoxin B1 Removal Ability
Authors: Limaye Aniket , Liu Je-Ruei
Published: August 2024

Introduction: Aflatoxin B1 (AFB1) is a potent hepatocarcinogenic mycotoxin found in animal feed and human food components. AFB1 contamination poses severe food safety and economic consequences. Methods: In this study, we used a coumarin-selective medium to isolate bacterial strains that can remove AFB1. Among the isolated bacterial strains, strain c4a exhibited the highest AFB1 removal activity. This strain was subjected to biochemical and phylogenetic characterization. The AFB1 removal activity of the extracellular supernatant of this strain was optimized for growth medium, reaction temperature, pH, and metal ions. The degradation products were analyzed using UPLC-ESI MS/MS. Results: Strain c4a was found to be most closely related to Chryseobacterium timonianum. The extracellular supernatant of C. timonianum c4a grown in a modified nutrient broth (with gelatin peptone and beef extract in a 4:1 ratio) demonstrated the highest AFB1 removal activity when incubated with 1 ppm AFB1 at 60°C, pH 8, and Mn2+ or Mg2+ supplementation for 72 h. Surprisingly, the autoclaved extracellular supernatant also retained AFB1 removal activity. UPLC-ESI MS/MS analysis suggested that AFB1 was transformed into a metabolite (m/z value 285.08) by water molecule addition on furan ring double bond. Conclusion: The AFB1 removal activity of C. timonianum c4a was extracellular, constitutive, and highly thermostable, structurally transforming AFB1 into a much less toxic product. Herein, we present the first evidence of thermostable AFB1 removal activity of a strain belonging to C. timonianum.
Comparison between Endobronchial Ultrasound-Guided Transbronchial Node Biopsy and Transbronchial Needle Aspiration: A Meta-Analysis
Authors: Yang Wuchen , Yang Huizhen , Zhang Quncheng , Herth Felix J.F. , Zhang Xiaoju
Published: August 2024

Introduction: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) can be limited by the inadequacy of intact tissues, especially in patients with lymphoma, sarcoidosis, and lymph node tuberculosis. A novel technique called transbronchial node biopsy (TBNB) by forceps or cryoprobe has been proposed and studied to improve specimen quality and diagnostic yield. We performed a systematic review of studies describing the safety and sensitivity of EBUS-TBNB versus EBUS-TBNA in diagnosing intrathoracic lymphadenopathy/masses. Methods: We systematically searched MEDLINE, Embase, Cochrane, and China National Knowledge Infrastructure to identify studies focusing on the application of EBUS-TBNB for diagnosis of intrathoracic lymphadenopathy. The quality of each study was evaluated using the QUADAS-2 tool. Using inverse-variance (I-V) weighting, we performed a meta-analysis of diagnostic yield estimations. We also reviewed the complications related to the procedure. Results: Thirteen studies were included in the final analysis. The meta-analysis yielded a pooled overall diagnostic yield of 77.80% (939/1,207) for EBUS-TBNA and 86.01% (834/958) for EBUS-TBNB, with an inverse-variance-weighted odds ratio of 3.13 (95% confidence interval [CI], 1.61–6.01; p = 0.0008) and I2 of 82%. The pooled diagnostic yield of EBUS-TBNB versus EBUS-TBNA for the diagnosis of malignancy (including primary lung cancer and extrapulmonary malignancy) was 84.53% (590/698) for EBUS-TBNA and 90.84% (476/524) for EBUS-TBNB, with an I-V-weighted OR of 2.33 (95% CI, 1.15–4.74; p = 0.02) and I2 of 64%. The pooled diagnostic yield of EBUS-TBNB versus EBUS-TBNA for the diagnosis of benignancy was 71.19% (252/354) for EBUS-TBNA and 86.62% (233/269) for EBUS-TBNB, with an I-V-weighted OR of 4.39 (95% CI, 2.00–9.65; p = 0.002) and I2 of 59%. The overall complications included bleeding (n = 11, 0.90%), pneumomediastinum (n = 6, 0.49%), pneumothorax (n = 6, 0.49%), pneumonia (n = 4, 0.33%), respiratory failure (n = 1, 0.08%), and haemoptysis (n = 1, 0.08%). The funnel plot analysis illustrated no major publication bias. Conclusions: EBUS-TBNB improves the overall diagnostic yield of sampling intrathoracic lymphadenopathy and mass lesions relative to EBUS-TBNA. The complication rate of EBUS-TBNB is higher than that of EBUS-TBNA but reportedly lower than that of surgical biopsies.
Economic Downturn, Economic Recovery, Economic Indicators, and Investment Opportunities
Authors: Singco Jeshua Mel C. , Narsico Peter G. , Narsico Lalaine O. , Polinar Mark Anthony N.
Published: August 2024

Economic downturns represent an inevitable challenge that nations and businesses must confront, presenting considerable risks. As a result, it becomes imperative for them to formulate strategies to secure their survival. The world has recently experienced an economic downturn due to a pandemic. COVID-19 has caused a significant economic crisis, leading to job losses and disruptions across various sectors worldwide, including the Philippines. The study utilizes economic indicators to determine patterns, meanings, and subsequent opportunities. Specifically, the study sought to identify relevant economic indicators, find patterns and meaning within each indicator and among indicators, and determine implications from findings. Content analysis was used in the study. It is a qualitative research method to identify and interpret themes, meanings, and patterns. The materials used include eleven Philippine economic indicators, namely, the Philippine Stock Exchange Composite Index, Balance of Trade, Core Inflation Rate, Consumer Spending, Tourist Arrivals, Consumer Confidence, Consumer Credit, Gold Reserves, Foreign Exchange Reserves, and Money Supply M2, and Interest Rate. In conclusion, the study determined that the collective surge in economic activities is positively related to the rise of inflation; increased interest rates potentially mitigated the rise in inflation, and other factors negated the trade deficits and gold reserve fluctuations. The Philippine economy is on the path to recovery, and the unique interrelations of economic indicators imply a more stable environment in the Philippine economy. This signals a green light for investors and an opportunity for policymakers to fine-tune existing initiatives to sustain economic recovery.
Mário Beni, o Engenheiro que Decolou no Turismo
Authors: Velozo Juarez
Published: August 2024

Reconocido por el mundo académico del turismo Mário Carlos Beni es autor del libro más utilizado en los programas de licenciatura de turismo en Brasil, Análise Estrutural do Turismo, y es el invitado para el relanzamiento de la sección de entrevistas de la Revista Turismo em Análise. Miembro del Consejo Nacional de Turismo de Brasil e investigador de renombre mundial, en esta conversación exclusiva nos habla de su trayectoria en el turismo, pasando por la arquitectura, el urbanismo y la política. También opina sobre diversos temas, como la llegada de la inteligencia artificial, los estudios posdoctorales, el ego y las traiciones en la academia. Apasionado de los nuevos conocimientos y gastrónomo en su tiempo libre, el catedrático repasa su carrera y dialoga con los investigadores contemporáneos y futuros. Esta entrevista tuvo lugar a distancia el 25 de marzo de 2023, con una hora de duración, y su contenido se ha transcrito íntegramente. En este medio se eternizará una historia personal que se entrelaza con la trayectoria de la enseñanza superior y de posgrado en Turismo en Brasil.
Incorporating Individual‐Level Treatment Effects and Outcome Preferences Into Personalized Blood Pressure Target Recommendations
Authors: Ascher Simon B. , Kravitz Richard L. , Scherzer Rebecca , Berry Jarett D. , de Lemos James A. , Estrella Michelle M. , Tancredi Daniel J. , Killeen Anthony A. , Ix Joachim H. , Shlipak Michael G.
Published: August 2024

Background

There are no shared decision‐making frameworks for selecting blood pressure (BP) targets for individuals with hypertension. This study addressed whether results from the SPRINT (Systolic Blood Pressure Intervention Trial) could be tailored to individuals using predicted risks and simulated preferences.

Methods and Results

Among 8202 SPRINT participants, Cox models were developed and internally validated to predict each individual's absolute difference in risk from intensive versus standard BP lowering for cardiovascular events, cognitive impairment, death, and serious adverse events (AEs). Individual treatment effects were combined using simulated preference weights into a net benefit, which represents a weighted sum of risk differences across outcomes. Net benefits were compared among those above versus below the median AE risk. In simulations for which cardiovascular, cognitive, and death events had much greater weight than the AEs of BP lowering, the median net benefit was 3.3 percentage points (interquartile range [IQR], 2.0–5.7), and 100% of participants had a net benefit favoring intensive BP lowering. When simulating benefits and harms to have similar weights, the median net benefit was 0.8 percentage points (IQR, 0.2–2.2), and 87% had a positive net benefit. Compared with participants at lower risk of AEs from BP lowering, those at higher risk had a greater net benefit from intensive BP lowering despite experiencing more AEs (
P
<0.001 in both simulations).

Conclusions

Most SPRINT participants had a predicted net benefit that favored intensive BP lowering, but the degree of net benefit varied considerably. Tailoring BP targets using each patient's risks and preferences may provide more refined BP target recommendations.
Subsequent Memory Effects in Cortical Pattern Similarity Differ by Semantic Class
Authors: Yu Christina , Huang Shenyang , Howard Cortney M. , Hovhannisyan Mariam , Clarke Alex , Cabeza Roberto , Davis Simon W.
Published: August 2024

Although living and nonliving stimuli are known to rely on distinct brain regions during perception, it is largely unknown if their episodic memory encoding mechanisms differ as well. To investigate this issue, we asked participants to encode object pictures (e.g., a picture of a tiger) and to retrieve them later in response to their names (e.g., word “tiger”). For each of four semantic classes (living-animate, living-inanimate, nonliving-large, and nonliving-small), we examined differences in the similarity in activation patterns (neural pattern similarity [NPS]) for subsequently remembered versus forgotten items. Higher NPS for remembered items suggests an advantage of within-class item similarity, whereas lower NPS for remembered items indicates an advantage for item distinctiveness. We expect NPS within class-specific regions to be higher for remembered than for forgotten items. For example, the parahippocampal cortex has a well-known role in scene processing [Aminoff, E. M., Kveraga, K., & Bar, M. The role of the parahippocampal cortex in cognition. Trends in Cognitive Sciences, 17, 379–390, 2013], and the anterior temporal and inferior frontal gyrus have well-known roles in object processing [Clarke, A., & Tyler, L. K. Object-specific semantic coding in human perirhinal cortex. Journal of Neuroscience, 34, 4766–4775, 2014]. As such, we expect to see higher NPS for remembered items in these regions pertaining to scenes and objects, respectively. Consistent with this hypothesis, in fusiform, parahippocampal, and retrosplenial regions, higher NPS predicted memory for subclasses of nonliving objects, whereas in the left inferior frontal and left retrosplenial regions, lower NPS predicted memory for subclasses of living objects. Taken together, the results support the idea that subsequent memory depends on a balance of similarity and distinctiveness and demonstrate that the neural mechanisms of episodic encoding differ across semantic categories.
Sir Francis Cook, Viscount of Monserrate, an Art Collector with Social and Scholastic Concerns
Authors: Neto Maria João , Neto Teresa
Published: August 2024

Sir Francis Cook, Viscount of Monserrate, was one of the most notable art collectors in the nineteenth century, exhibiting hundreds of Old Master’s paintings, among other collections, at his main residence in Richmond, near London. As for his country home, Cook rehabilitated Monserrate in Sintra, Portugal, an estate once leased by William Beckford – there, Cook selected fascinating pieces, evoking the famous novelist and collector. Adding to previous studies on Cook’s collection, this paper aims to assess his taste, motivations and counsel for creating the collections, as well as how the collection was managed for personal enjoyment, social, and scholastic concerns.
Compliance Factors in Malaysian Guidelines for Hadith Authentication
Authors: Bahrudin Mohamad Khalid , Suliaman Ishak , Adnan Mohamad Azrien Mohamed
Published: August 2024

In 2018, Ministry of Home Affairs (MOHA) of Malaysia issued the Guideline for Writing and Publishing Hadith Texts (Garis Panduan Penulisan dan Penerbitan Teks Hadith) through Hadith Review and Assessment Committee (HRAC) to ensure high-quality hadith texts. A survey of 61 industry representatives revealed a moderate compliance level with a mean score of 2.69. This study uses quantitative methods, including descriptive and inferential analysis, to identify factors influencing compliance. Ten factors were measured, such as guideline characteristics, author/editor bias, publication type, company orientation, promotional strategies, guideline producer, law enforcement impact, training, incentives, and bureaucracy. The survey instrument demonstrated high reliability (Cronbach’s Alpha = .903), and data analysis via SPSS 27 showed that most factors had high mean scores (> 3.68), except for publication type (2.21) and company orientation (2.00). Multiple regression analysis identified aggressive promotional strategies and law enforcement as significant positive influences on compliance.
The Dynamism of the Social Literary and Hermeneutical Streams in Qurʾanic Classical and Modern Exegesis Studies
Authors: Amir Selamat bin , Hilmi Ahmad Bazli Ahmad , Abdullah Mustaffa bin , Norasid Muhamad Alihanafiah
Published: August 2024

Among the Qurʾanic exegesis streams that have emerged due to social changes and current developments in human civilisation, such as [specific social changes and developments], are the social literary (tafsīr al-adabī al-ijtimāʿī) stream and the hermeneutic. Both streams have their framework, phase, and factor from the time of their emergence and have their position in the method of Qurʾanic exegesis. This study discusses these two streams as a central debate in line with the historical and philosophical correlation of the evolution from classical to modern interpretations from various perspectives and in the context of the Islamic and Western world. This qualitative study used library research and comparative study on the social literary stream and hermeneutic, supported by other related written materials. The study finds that the social literary stream and hermeneutics differ in origin and methodology. The social literary stream is an interpretation that discusses Qurʾanic verses with the aesthetic value of language literature and its correlation with the elements of society. It can solve problems, counter hostility towards Islam, and treat diseases that exist in society with the guidance of the Qurʾan. Hermeneutic is a method of interpreting or expressing meaning in a text, originally referring to the Bible, originated from Greek mythology, which then developed in Christian culture and is now beginning to influence the method of interpreting the Quran. It is unsuitable for interpreting the Qurʾan because it would raise doubts (skepticism and relativism) about the equation of the Qurʾanic text with ordinary texts.
Content Analysis Study of Prophetic Prayer Medicament in Kitab Tib MSS1653 Malay Medical Manuscript
Authors: Ibrahim Norhasnira , Shah Faisal Ahmad
Published: August 2024

Prophetic medicaments are mentioned in hadith literature, which records the sayings, actions, and approvals of the Prophet Muhammad. His teachings and practices serve various functions, including guidance on maintaining good health and treating illnesses. Historically, one of the well-known Prophetic medicaments found in Malay medical manuscripts is reciting prayers as protection against illness, to cure diseases, and for good health derived from hadith texts. Thus, this article delves into analyse of the Prophets’ prayer medicaments practiced in Malay medical treatment by focusing on the Kitab Tib MSS1653 manuscript. The study is descriptive library research by applying the qualitative content analysis method. The data was then analysed by using inductive, deductive, and comparative methods between hadith and Malay medical practices in healing diseases. The result shows that 17 hadiths were mentioned as prayer recitations in this manuscript and practiced by the Malay community in their medical treatment. It is proof that Prophetic prayer medicament and Malay medical treatment are important and complement physical treatments by reciting prayers and seeking divine assistance as integral parts of the healing process.
Gagasan Malaysia Madani: Analisis Korelasi Enam Nilai Teras Ketamadunan Daripada Kisah Nabi Sulayman (As) Dalam Surah Al-Naml
Authors: Nasir Khairulnazrin , Zaman Rahim Kamarul , Ahmad Khalilullah Amin
Published: August 2024

Al-Quran has provided theoretical and practical guidance on the position of state institutions in Islam. One of the surahs that discusses the principles of statehood is Surah al-Naml. This surah, which contains 93 verses, tells the story of Prophet Sulayman (PBUH), a prophet and king who was blessed with wisdom and a great empire. Lately, there have been concerns over the erosion of values and integrity due to the spread of materialism, individualism, and hedonism. This has guided the idea of Madani Malaysia, which was introduced by the 10th Prime Minister of Malaysia, Anwar Ibrahim, in January 2023 to optimally apply core values to the people and leaders. Meanwhile, the story of Prophet Sulayman (PBUH) is a civilisation highlighted by the Quran in Surah al-Naml. However, is there a correlation between the core values of Madani Malaysia and the values contained in the story of Prophet Sulayman (PBUH)? This question leads to this study, which tries to identify the correlation aspect between the two core values. Using a qualitative approach based on literature, content analysis was conducted on the official documents of Madani Malaysia and the scholars’ interpretation of the story of Prophet Sulayman (PBUH). The findings of the study show that the six core values of Madani Malaysia, namely sustainability, well-being, creativity, respect, confidence, and courtesy have a significant link with the lessons and values contained in the story of Prophet Sulayman (PBUH), whether in His Majesty’s own character, ants, hudhud, Queen Balqis, and the dignitaries, both conceptually and practically. Overall, the application of these core values can drive Malaysia towards a developed and highly civilised country.
الاكتئاب النفسي، أسبابه وعلاجه في ضوء القران الكريم: دراسة تطبيقية على حالة الجالية اليمنية في ماليزيا
Authors: Amer Abdulwahab Mahyoub Murshed , Murshed Zinab Abdulwahab Mahyoub
Published: August 2024

According to the Quran, depression in general is attributed to a lack of religious commitment among Muslims, as well as the accumulation of sadness, anxiety, fear, disorder, psychological pressure, and issues related to family, social, cultural, economic, and political relationships. In the light of the challenges faced by the Yemeni community in Malaysia due to forced displacement from Yemen and the resulting lack of security from this traumatic experience and the inability to return, this study aims to uncover the nature, causes, and effects of psychological depression. Additionally, it seeks to identify proposals for alleviating symptoms based on the perspectives of a sample of 45 individuals from the Yemeni community in Malaysia. The researchers employed descriptive and analytical methods, and the study’s theoretical findings were consistent with field observations. The primary cause of depression was found to be fear for the well-being of loved ones, with significant impact stemming from anxiety and stress about the future. One of the key suggestions for alleviation was fostering certainty in future benefits.
Forgotten Buddhist Literatures as Revealed by Manuscript Discoveries in India and Beyond
Authors: Salomon Richard G.
Published: August 2024

In the early phases of the modern study of Buddhism, it was widely assumed that the Buddhist canon preserved in the Pali language by the Theravāda tradition of Sri Lanka and Southeast Asia represented the only original record of the “words of the Buddha” (buddha-vacana). But the notion of Pali primacy has been steadily eroded by discoveries of vast numbers of early Buddhist manuscripts in the formerly Buddhist regions of northwestern India and adjoining countries and in Central Asia. These discoveries have provided ample evidence of the existence in antiquity of voluminous bodies of Buddhist literature in Sanskrit and Gandhari that are parallel to and as historically valid as the Pali versions. They have shifted the perception of Buddhism away from a linear model and toward a wider understanding of the many Buddhisms that coexisted in antiquity. This article surveys some of the major discoveries of Buddhist manuscripts and summarizes the new perspectives that they have engendered.
Understanding Variation in Integrated STEM Practice as Measured by the STEM Observation Protocol (STEM-OP)
Authors: Dare Emily A. , Ring-Whalen Elizabeth A.
Published: August 2024

To better understand integrated STEM education, this work explored scores on the STEM Observation Protocol (STEM-OP), a newly developed observation protocol for use in K-12 science and engineering classrooms. The goals of this work were to better understand how integrated STEM might look throughout an integrated STEM unit and identify limitations of the instrument when examining daily scores and full unit implementation scores. The work takes a mixed methods approach to first examine what scores may be typically seen with daily and unit implementations. After identifying an exemplar integrated curriculum unit with consistently high daily scores, the authors qualitatively explore the fluctuations in protocol scores over the course of a curriculum unit implementation. Our work reveals that some items on the protocol may vary throughout implementation, while also demonstrating that achieving the highest scores on all items during one lesson or even throughout a full curriculum unit is challenging.
Transculturality and the Eco-Logic of Memory
Authors: Erll Astrid
Published: August 2024

This article asks how memory studies might use the conceptual insights gained during its “third transcultural phase” for the challenges of its “fourth phase” – heralded in this Special Issue as a phase of research invested in questions about memory and the environment. It argues that memory is fundamentally “eco-logical”, and that the relational dynamics explored in research on transcultural memory can enable an understanding of the more-than-human in collective memory. The article offers a brief introduction to the field of memory studies and its transcultural turn around 2010. It traces the emergence of transcultural studies as a field of enquiry and its roots in research on colonialism, postcolonialism, and cultural globalisation. It discusses new developments in memory studies and considers their transcultural and broader eco-logical dimensions. Finally, the article distinguishes between “the relationality of the remembered”, “relational remembering”, and “mnemonic relationality” as conceptual building blocks for eco-logical mnemohistories.
Feminist Posthumanism, Environment and “Response-Able Memory”
Authors: Gündoğan İbrişim Deniz
Published: August 2024

This article explores the entangled relationship between memory and environment through a feminist posthumanist framework while it takes seriously an ecological and response-able perspective in shaping the traumatic past and the troubled climatic present. In so doing, it introduces the concept of “response-able memory” which encourages us to reimagine the established humanist underpinnings in cultural memory studies. In order to discuss how “response-able memory” surfaces as a mode of enquiry and highly productive new strategy to accommodate nonanthropogenic and entangled ways of remembrance in the twenty-first century, this article examines Zarina Muhammad’s (b.1982, Singapore) contemporary art which is deeply entwined with a critical re-examination of local histories and silenced (female) accounts in Southeast Asia.
A new white-flowered Elleanthus (Orchidaceae: Sobralieae) from the Andes of southern Ecuador and notes on hummingbird pollination of Elleanthus scopula
Authors: JIMÉNEZ MARCO M. , KUETHE J.R. , GARZÓN-SUÁREZ HENRY X. , LAPO-GONZÁLEZ NADIA , VÉLEZ-ABARCA LEISBERTH , SALAGAJE M. LUIS A. , ITURRALDE GABRIEL A.
Published: August 2024

A new species of Elleanthus from southern Ecuador is described and illustrated here. Elleanthus loxensis is characterized by having ramified stems with coriaceous, plicate leaves and white flowers. Its ecological, morphological, and taxonomic traits are compared with other similar species within the genus and discussed here. Additionally, comments on the pollination of Elleanthus scopula are presented.
A new species of Meriania (Melastomataceae: Merianieae) from southeastern Ecuador
Authors: JIMÉNEZ MARCO M. , ITURRALDE GABRIEL A. , MENDOZA JOHNY , OCUPA-HORNA LUIS , GARZÓN-SUÁREZ HENRY X.
Published: August 2024

Meriania judithiae, a new species from the southeast of Morona Santiago in Ecuador, is described and illustrated. With this new addition, the number of species of the genus increases to 33 in this country. Meriania judithiae has leaves with a attenuate base extending down the petiole as wings, multiflorous inflorescences with sub-umbellate paraclades, pink-orange campanulate flowers, the calyx with conical projections, and isomorphic stamens with connectives prolonged below the thecae. It is compared with M. cuneifolia, its most similar species which shares the distant supra-basal venation and gradually narrowing base of the leaves. In addition, the taxonomic similarities of the new entity are discussed and information about its distribution, habitat, and conservation status is provided.
Fritillaria shahuensis (Liliaceae), a new species from western Iran
Authors: ADVAY MAHFOUZ , RIX MARTYN
Published: August 2024

A new species, Fritillaria shahuensis, from western Iran is described. It is similar in general facies to F. atrolineata and F. chlorantha in the F. caucasica-group but differs mainly in colour and size of lowest leaves and shape and colour of perigone segments. Fritillaria shahuensis is also similar in general facies to F. assyriaca and F. kordestanica but differs mainly by colour of perigone segments. Detailed taxonomic descriptions, diagnostic characters, original photographs, geographical distributions, habitat, phenology and ecology, etymology and conservation status of the new and related species are presented.
Beyond appearances: the genus Ernassa Walker, 1856 (Lepidoptera, Erebidae, Arctiinae, Phaegopterina) and the description of eight new species
Authors: GRADOS JUAN
Published: August 2024

The genus Ernassa Walker currently consists of five species: Ernassa justina (Stoll), E. sanguinolenta (Cramer), E. ignata Travassos, E. gabrielae Travassos, and E. cruenta (Rothschild). For about 40 years, the genus has been treated with these species. However, a large series of specimens and the study of the characters of the male genitalia, makes evident that the genus is more diverse. Eight new species are described: Ernassa inexplorata sp. nov., E. rufula sp. nov., E. persivalei sp. nov., E. tarisca sp. nov., E. skinnerorum sp. nov., E. harveyi sp. nov., E. markpacei sp. nov. and E. abscondita sp. nov. This work proposes that the species E. cruenta (Rothschild) does not have a common origin with the other species of the genus. At the moment it is treated as incertae sedis.
Contribution to the knowledge of the Philippines species of the tribe Odacanthini Laporte, 1834 (Coleoptera: Carabidae)
Authors: ANICHTCHENKO ALEXANDER , SCIAKY RICCARDO
Published: August 2024

In this work we describe a new species from the Philippines (Luzon Island). Archicolliuris albolineata sp. n. is allied to A. tenuis from Borneo and Palawan, and can be distinguished by having the much longer elytral white stripe and the wider pronotum. Three species, Mimocolliuris (Paramimocolliuris) insulana Habu, 1979; Ophionea (s. str.) celebensis Baehr, 1996 and Ophionea (Procasnoidea) foersteri Bouchard, 1903, are recorded for the first time in the Philippines. Some new nomenclatural acts are here proposed: Colliuris philippinensis Donabauer, 1996 = Mimocolliuris philippinensis (Donabauer, 1996) n. comb.; Ophionea (Setophionea) ishiii hoashii Habu, 1961 = Ophionea (Setophionea) ishiii ishiii Habu, 1961 n. syn.; Casnoidea (s. str.) leytensis Baehr, 1996 = Ophionea (Setophionea) ishiii ishiii Habu, 1961 n. syn.; Ophionea (s. str.) bhamoensis Bates, 1892 = Ophionea (s. str.) bakeri Dupuis, 1913 n. syn.; Ophionea (s. str.) bhamoensis Bates, 1892 = Ophionea bhamoensis taiwanensis Terada & Wu, 2014 n. syn. Numerous taxonomic comments are also provided. Illustrations of the habitus of all the species are given, and new distributional data are provided.
Impact of Arctic Stratospheric Polar Vortex on Mediterranean Precipitation
Authors: Zhang Chongyang , Zhang Jiankai , Xia Xufan , Li Douwang
Published: August 2024

The Mediterranean precipitation has significant implications for the local ecology and human livelihoods. This study explores the impact of the Arctic stratospheric polar vortex on the Mediterranean precipitation during the wet season (winter) using reanalysis data and large-scale ensemble experiments that are forced by anomalous stratospheric polar vortex states. Our findings reveal that total and extreme precipitation over the Mediterranean region are increased under weak polar vortex (WPV) conditions and decreased under strong polar vortex (SPV) conditions. Moisture budget suggests that the changes in vertical motion over the Mediterranean play the dominant role in precipitation changes. It is further found that the tropospheric quasi-stationary wave train propagating from Greenland to the European continent is enhanced under WPV conditions, accompanied by warming advection over the eastern Mediterranean and vorticity advection in the upper troposphere over the whole region of the Mediterranean. Consequently, the vertical motion and precipitation there are enhanced. The southward shift of the Atlantic jet stream under WPV conditions leads to enhanced moisture transport toward the Mediterranean, providing a favorable moisture source for precipitation. In addition, the background baroclinicity in the lower troposphere around the northern Mediterranean is enhanced under WPV conditions, intensifying frontogenesis and cyclonic activities, which are commonly accompanied by intensified precipitation. These results are consistent with earlier literature and suggest that the changes in the stratospheric polar vortex may be used as a potential predicting factor for Mediterranean precipitation.
Vertical Velocity 3D Estimates from the Linear Vorticity Balance in the North Atlantic Ocean
Authors: Cortés-Morales Diego , Lazar Alban
Published: August 2024

Large-scale three-dimensional vertical movements of the world’s oceans play a fundamental role in their functioning, yet they are still overlooked. This study aims to enhance our understanding of the relationship between horizontal and vertical flows as a function of depth to derive some major characteristics of the w field from a relatively well-constrained variable. For this purpose, we analyze an eddy-permitting ocean general circulation model simulation, focusing on the linear vorticity balance (LVB) over the North Atlantic basin. For spatial scales greater than 5°, over more than 50-yr average, the LVB holds with less than 10% error over the whole depth range of most of the subtropical upper tachocline–upper ocean and part of the tropical one, away from western boundary currents and zonal tropical flows. The spatial extent of the balance diminishes in the intermediate ocean, particularly in the western half of the basin. Within the deep tachocline, the balance holds over large portions of the abyssal plains. Based on these results, the β-plane geostrophic vertical velocity is derived from the vertical indefinite integral of the geostrophic LVB from the surface. While its time mean aligns only qualitatively with the model reference w, it accurately captures the interannual variability over most of the basin, even close to eastern boundaries. However, it cannot reproduce the variability in the lower tropics, the western boundary, and the North Atlantic Current system. Our results emphasize the dominance of geostrophy in establishing most of the ocean model vertical flow variability.
Detection vehicle lateral offset overestimation on asphalt pavement rut depth measurement accuracy
Authors: Gao Yuan , Yan Jiao , Hui Bing
Published: August 2024

The 13-point laser detection vehicle is widely used for the rapid detection of rutting on national and provincial trunk lines in China. Affected by the road alignment and drivers’ human factors, the inspection vehicle will inevitably shift laterally during the inspection process. Offset wandering of an automated measurement vehicle on the overestimation of rut depth was investigated and analyzed with the objective of determining the impact of this phenomenon on the accurate and timely selection of maintenance and rehabilitation (M&R) actions. For this purpose, three representative rut types commonly used in China with high and medium severity levels of rutting were selected from field surveys and studied. For each rut type, the cross sections with a rut depth between 10 and 15 mm were selected to study the impact of different offset distances on the measurement accuracy. The reliability of lateral offset detection was further validated by simulating different rut shapes. Finally, an error judgment parameter E was implemented and evaluated. The results showed that the overestimation could be observed only at an offset distance lager than 300 mm. The maximum percentage of overestimation could be as high as 86.0%, 93.3%, and 67.5% for Types 1, 2, and 3 rut shapes respectively. The presence of a central upheaval was a dominant factor which reduced the error parameter E. The calculation of the severity error judgment E indicated that the errors were mainly governed by the offset distance; the maximum ratio was 13.0% for 300 mm, and dramatically increased up to 61.3% for 500 mm. Therefore, the maximum acceptable offset within which reliable M&R decision could be taken was 300 mm.
Returning Veterans’ Attitudes Toward Democracy: Evidence From a Survey of Ukraine’s ATO Veterans
Authors: Ash Konstantin , Shapovalov Miroslav
Published: August 2024

How is service history associated with returning veterans' attitudes about democracy? Existing research predicts pro-government militia veterans have less support for democracy because of political efficacy gained from service and divergent policy preferences from the general population. We test that theory in Ukraine through surveys of both returning veterans and the general population between 2019 and 2022. Our findings differ from predictions. Veterans who joined the armed forces as volunteers were more supportive of democracy as an institution than ordinary Ukrainians. At the same time, Army volunteers, as well as veterans who were drafted into the armed forces and veterans who were rejected from the armed forces and joined pro-government militias were more likely to be dissatisfied with democracy. In-depth interviews reveal both those rejected from the armed forces and army conscripts opposed democracy because they felt rampant draft evasion made civilians unqualified to make political decisions.
From Intention to Action: How Preservice Teachers Use Technology-Enabled Learning During Student Teaching
Authors: Watson Jessica Herring
Published: August 2024

This qualitative, embedded single case study provides a rich description exploring the evolution of preservice teachers’ intention to use and actual use of technology-enabled learning (TEL) during student teaching. The study followed four middle-level education majors at a mid-size public teaching university in the southeastern United States during their student teaching experience (spring 2021). Ajzen’s Theory of Planned Behavior (TPB) guided this qualitative inquiry. Interviews, observations, and analysis of teaching artifacts (e.g., lesson plans, lesson reflections, and TEL artifacts) were conducted to support data triangulation. In addition to applying theory-based qualitative codes to the data, open coding was conducted to identify themes across the body of evidence. Findings extended previous TPB research regarding preservice teachers’ intention to use TEL in application use cases and yield practical implications for teacher educators seeking to increase TEL intention and use in preservice teacher populations.
Using Interactive Television Instruction (ITV) to Reduce the Propensity to Engage in Substance Abuse and Drug Trafficking Among Vulnerable Adolescents in Nigeria
Authors: Gever Verlumun Celestine
Published: August 2024

This study examined the impact of ITV intervention on reduction in the propensity to abuse substances and engage in drug trafficking. The researcher conducted this study using an experiment of 517 vulnerable adolescents aged 10–19 years. The participants were randomly assigned to control ( n = 258) and treatment ( n = 259) groups. The researchers found a significant main effect of treatment conditions on reduction in the propensity to engage in substance abuse and drug trafficking among vulnerable adolescents. That is, before the intervention, there was no significant statistical difference between the control and treatment groups on the propensity to engage in substance abuse and drug trafficking. However, vulnerable children who received the intervention reported a significant reduction in propensity after the intervention. The results highlight the usefulness of ITV as a behaviour change strategy for vulnerable children.