bluuebunny/crossref_metadata_2025 huggingface dataset:
Kewenangan Ketua Mahkamah Agung Mengeluarkan Surat Keputusan Ketua Mahkamah Agung Nomor 73/KMA/HK.01/IX/2015 Perihal Penyumpahan Advokat
Authors: Asyura Muttaqin , A. Rani Faisal , Ismail Ilyas
Published: June 2020

Angka 6 Surat Keputusan Ketua Mahkamah Agung Nomor 73/KMA/HK.01/IX/2015 perihal Penyumpahan Advokat (SK KMA Penyumpahan Advokat) menimbulkan polemik hukum karena substansi materi keputusan tersebut memperluas Putusan Mahkamah Konstitusi berkaitan dengan Organisasi Advokat yang dapat mengajukan penyumpahan Advokat di Pengadilan Tinggi. Terkait dengan hal tersebut apakah Ketua Mahkamah Agung memiliki kewenangan untuk mengeluarkan SK KMA Penyumpahan Advokat? Teori freies ermessen menekankan bahwa setiap pejabat pemerintahan memiliki kewenangan untuk membuat keputusan agar dapat berperan secara maksimal dalam melayani kepentingan masyarakat, namun keputusan yang dibuat harus sesuai dengan asas-asas umum pemerintahan yang baik. Berlakunya SK KMA Penyumpahan Advokat memperluas makna Organisasi Advokat yang telah diatur sebelumnya dalam  Putusan Mahkamah Konstitusi. Ketidakpastian hukum yang ditimbulkan oleh keputusan pejabat pemerintahan bertentangan dengan asas-asas umum pemerintahan yang baik, sehingga dengan demikian, Ketua Mahkamah Agung tidak berwenang mengeluarkan SK KMA Penyumpahan Advokat untuk mengatur mengenai Organisasi Advokat yang dapat mengajukan sumpah di Pengadilan Tinggi.Clause 6 a Decree Number 73/KMA/HK.01/IX/2015 on the Oath of an Advocate leads to legal issues due to expanding the decision of the Constitutional Court regarding advocate organization that can submit an oath of an advocate in the high court. Based on that issue, Is the Chief Justice of the Supreme Court authorized to issue a Decree Number 73/KMA/HK.01/IX/2015 on the Oath of an Advocate? Freies Ermessen’s theory states that every government official has authority to make a decree in order to serving public administration. But, the decree must be in accordance with the General  Principles of Proper Administration (GPPA). The enactment of the  Decree on the Oath of an Advocate leads to legal issues due to expanding the decision of the Constitutional Court. Legal uncertainty caused by the Decree is contrary to the General Principles of Proper Administration (GPPA). Therefore, the Chief Justice of the Supreme Court  is not authorized to issue a Decree Number 73/KMA/HK.01/IX/2015 on The Oath of an Advocate to regulate an Advocate Organization that can submit an oath in a High Court.
Kewenangan Pengangkatan Pejabat Di Lingkungan Dinas Kependudukan Dan Pencatatan Sipil Kabupaten Nagan Raya
Authors: Jalizar Agus
Published: June 2020

Pasal 18 ayat (2) Undang-Undang Dasar 1945 menyatakan bahwa pemerintahan provinsi, kabupaten dan kota mengatur dan mengurus sendiri urusan pemerintahan menurut asas otonomi daerah dan tugas pembantuan, pengaturan Lebih lanjut diatur dalam Undang-Undang Nomor 23 Tahun 2014 tentang Pemerintahan Daerah dan Khusus Provinsi Aceh diatur secara Khusus berdasarkan Undang-undang Nomor 11 Tahun 2006 Tentang Pemerintahan Aceh, dalam Pasal 110 ayat (4) Undang-Undang Nomor 11 Tahun 2006 menyebutkan bahwa Bupati/Walikota berewenang mengangkat Pejabat pada instansi perangkat daerah, namun di Kabupaten Nagan Raya pengangkatan Pejabat dilingkungan Dinas Kependudukan dan Pencatatan Sipil Kabupaten Nagan Raya mendapatkan surat perintah pembatalan oleh Menteri Dalam Negeri karena menurut Pasal 83A Undang-Undang Nomor 24 tahun 2013 Tentang Administrasi Kependudukan merupakan kewenangan Menteri Dalam Negeri, Apakah pengangkatan Pejabat di lingkungan Dinas Kependudukan dan Pencatatan Sipil Kabupaten Nagan Raya sudah sesuai dengan Peraturan Perundang-undangan yang berlaku. Penelitian ini menggunakan jenis penelitian Yuridis Normatif yang merupakan metode peneltian hukum yang dilakukan dengan meneliti bahan pustaka dan data sekunder belaka. Hasil Penelitian menunjukkan bahwa pengangkatan pejabat pada Dinas Kependudukan dan pencatatan Sipil Kabupaten Nagan Raya sesuai dengan peraturan perundang-undangan yang berlaku berdasarkan Undang-Undang Nomor 11 Tahun 2006 Tentang Pemerintahan Aceh, Undang-Undang Nomor 23 Tahun 2014 Tentang Pemerintahan Daerah dan Undang-Undang Nomor 5 Tahun 2014 Tentang Aparatur Sipil Negara, pengangkatan Pejabat dilingkungan perangkat daerah bagian dari pelaksanaan otonomi daerah sebagaimana diamanatkan dalam Pasal 18 ayat (2) Undang-Undang Dasar 1945, sehingga Pasal 83A Undang-Undang Nomor 24 tahun 2013 Tentang Administrasi Kependudukan bertentangan dengan Undang-Undang Dasar 1945 sebagai peraturan tertinggi.
Tindakan Passing Off Terhadap Merek Dalam Pemakaian Nama Perseroan Terbatas di Indonesia
Authors: Pentakosta Kimham
Published: June 2020

Tulisan ini mengkritisi adanya suatu celah dalam peraturan perundang-undangan mengenai pemakaian nama suatu Perseroan Terbatas apabila pengaturan tersebut ditinjau dari aspek perlindungan hak kekayaan intelektual, dimana terdapat kemungkinan seseorang yang tidak memiliki itikad baik untuk dapat melakukan tindakan pemboncengan reputasi (passing off) terhadap suatu merek terdaftar milik orang lain. Tulisan ini mengambil kesimpulan bahwa pemerintah perlu melakukan perubahan terhadap Peraturan Pemerintah Republik Indonesia Nomor 43 Tahun 2011 tentang Tata Cara Pengajuan Dan Pemakaian Nama Perseroan Terbatas, khususnya dalam memberikan perlindungan hukum bagi pemilik merek terdaftar yang nama mereknya secara sengaja digunakan sebagai nama perusahaan (perseroan terbatas) oleh pihak lain.
Studi Kasus Terhadap Putusan Pengadilan Negeri Kuala Simpang Nomor : 11/PID.SUS-ANAK/2017/PN.KSP Tentang Tindak Pidana Perdagangan Orang Yang Dilakukan Oleh Anak
Authors: Amanda Desty , Tarmizi Tarmizi
Published: June 2020

Putusan Nomor : 11/Pid.Sus-Anak/2017/PN.Ksp Terdakwa I Nursyafarilla dan Terdakwa II Elvina Tari terbukti secara sah dan menyakinkan bersalah melakukan Tindak Pidana sebagaimana diatur dan diancam pidana dalam Pasal 88 Jo. Pasal 76I Undang-Undang RI Nomor 35 Tahun 2014 tentang Perubahan Atas Undang-Undang RI Nomor 23 Tahun 2002 tentang Perlindungan Anak. Tujuan penulisan studi kasus ini untuk menganalisis tindakan Hakim yang tidak mempertimbangkan persepsi/pandangan hukum yang terbukti melanggar Pasal 88 Jo. Pasal 76I Undang-Undang Perlindungan Anak. Penelitian ini berdasarkan tujuannya termasuk dalam penelitian normatif. Berdasakan fakta-fakta di persidangan dan putusan Pengadilan Negeri Kuala Simpang Nomor: 11/Pid.Sus-Anak/2017/PN.Ksp menjelaskan tidak ditemukan upaya Majelis Hakim untuk mempertimbangkan Pasal 88 Jo. Pasal 76I Undang-Undang Perlindungan Anak, sehingga menyebabkan penjatuhan pidana percobaan selama 3 (tiga) bulan dan terdakwa tidak ditahan. Berdasarkan analisis putusan Pengadilan Negeri Kuala Simpang Nomor : 11/Pid.Sus-Anak/2017/PN.Ksp dinilai tidak memberikan efek jera dan menyadarkan para anak akan kesalahannya. Disarankan kepada Majelis Hakim untuk lebih teliti dalam memperhatikan fakta-fakta hukum di persidangan yang dapat membuktikan kesalahan terdakwa.
A case report of splenic artery embolization after delayed presentation following blunt abdominal trauma, complicated by multiple large splenic artery pseudoaneurysms
Authors: Nandurkar Rohan , Kuang Ronny , Clements Warren
Published: June 2020

Background:

Splenic laceration is the most common injury following blunt abdominal trauma. The injury is characterized by the presence of parenchymal laceration; however, vascular lesions may also be seen such as pseudoaneurysms. Multiple pseudoaneurysms are rare complication. Delayed treatment is traditionally with splenectomy, however, small case series of the use of embolization have been described.

Case Presentation:

A 29-year-old female presented with left upper quadrant pain 22 days after a motor vehicle accident; she was hemodynamically stable. Computed tomography imaging with contrast enhancement demonstrated American Association Staging of Trauma grade IV splenic artery injury with multiple large splenic artery pseudoaneurysms. The patient proceeded to angiography and was treated with proximal coil embolization. Ultrasound demonstrated pseudoaneurysm thrombosis at 4 days and again at 6 weeks after treatment.

Conclusion:

This case demonstrates the success of splenic artery embolization in achieving non-operative management of blunt splenic injury in a sub-acute setting, even with the presence of multiple large splenic artery pseudoaneurysms.
Situación y retos de la cooperación española para el fortalecimiento de las instituciones públicas
Authors: Bandeira Greño Pablo , Warleta González Arturo
Published: June 2020

This article analyzes the situation and the current challenges of Spanish development assistance aimed at public institutional development. First, we try to define what we mean by the concept of "public institutional development", as against the idea of "increasing organizational resources". Secondly we analyze the quantitative importance of Spanish cooperation granted to such actions based mainly on the 2010 PACI tracking database. Then we the main strengths and weaknesses of our cooperation in this sector, on the basis of semi-open interviews carried out with technical personnel of three public cooperation agencies, 17 NGO and the evaluations carried out by the Directorate- General of planning and evaluation of development policies. The article ends with a series of conclusions and recommendations for the Spanish aid in this sector to be more effective.
Estudio de la insolvencia empresarial en las cooperativas mediante técnicas multivariantes
Authors: Pozuelo Campillo José Ana , Martínez Vargas Julián , Carmona Ibáñez Pedro
Published: June 2020

One of the consequences of the current economic crisis is a significant rise in business failures, which is fueling the interest of researchers and users for its analysis, review and update of the traditional models.In reviewing the financial literature on business failure in our country, we noticed that the are very few studies focusing exclusively on cooperative enterprises, although this kind of companies have a broad presence in our country. This significant lack of studies on this kind of business, the recent availability of large databases and the current economic circumstances have influenced us to undertake this work. The main paper objective focuses on the estimation of appropriate models to predict business failure in cooperative enterprises, using statistical techniques.
SIMULASI SISTEM KENDALI BERBASIS PERILAKU PADA AUTONOMOUS MOBILE ROBOT DENGAN METODA Q-LEARNING
Authors: Setianingsih Casi , Mutijarsa Kusprasapta , Murti Muhammad Ary
Published: June 2020

Autonomous robot adalah suatu robot yang mampu bekerja secara mandiri tanpa pengendalian langsung dari manusia. Robot bekerja berdasarkan sensor-sensor yang dimilikinya, mengambil keputusan sendiri untuk menyelesaikan misi dalam lingkungan kerjanya. Dalam dunia nyata, lingkungan kerja robot sangat dinamis, selalu berubah, dan tidak terstruktur. Membuat suatu model lingkungan yang tidak terstruktur sangat sulit. Memperoleh model matematik yang tepat dari lingkungan seperti ini hampir tidak mungkin dilakukan. Untuk membuat suatu autonomous mobile robots yang mampu bekerja pada lingkungan yang tidak terstruktur dan dinamis,diperlukansuatumetodatertentuyangadaptifdanmampubelajar. Berdasarkan permasalahan tersebut maka pada riset ini dirancang suatu autonomous mobile robot dengan arsitektur berbasis perilaku yang dapat belajar dan bekerja secara mandiri pada lingkungan yang tidak terstruktur, menggunakan metoda Reinforcement Learning. Tujuan metoda ini diterapkan agar robot mampu belajar dan beradaptasi terhadap lingkungan yang tidak terstruktur. Selanjutnya robot dikembangkan agar mampu menyelesaikan misi menemukan target pada posisi tertentu berdasarkan informasi yang diperoleh dari sensor sensor yang ada. Hasil simulasi menunjukan bahwa algoritma pembelajaran Reinforcement Learning berhasil diterapkan pada arsitektur kendali berbasis perilaku di autonomous mobile robot dengan akurasi sebesar 85,71%.
Elective sclerotherapy of an orbital lymphatic malformation: A case report and review of the literature
Authors: Reis Joseph
Published: June 2020

Orbital lymphatic malformations (LMs) are a unique subtype of vascular anomaly that can swell and lead to blindness if left untreated in the acute setting. Detrimental acute and chronic effects of the malformation on vision suggest that treatment should be considered pre-emptively rather than in the acute setting. We describe the effectiveness and safety of treating these LMs electively using sclerotherapy, a minimally invasive treatment method.
Greater specificity of p40 compared with p63 in distinguishing squamous cell carcinoma from adenocarcinoma in effusion cellblocks
Authors: Kim Nah Ihm , Lee Ji Shin
Published: June 2020

Objective:

Squamous cell carcinoma (SCC) rarely causes malignant effusions. Distinguishing between SCC and adenocarcinoma in effusion cytology can be a challenge. p63 and p40 have been frequently used to support squamous cell differentiation in both histological and cytological specimens. However, similar results in cytological preparations of effusion fluids have been rarely reported. This study was designed to assess the diagnostic value of p63 and p40 immunoreactivity for the differentiation of SCC from adenocarcinoma in malignant effusions.

Materials and Methods:

Immunocytochemical staining of p63 and p40 was performed on thirty cellblock specimens, including ten malignant effusions carrying SCC and twenty malignant effusions showing adenocarcinoma. Any degree of nuclear staining was considered positive.

Results:

Of the ten SCC cases, 100% tested positive for both p63 and p40, and most cases showed diffuse staining (>25% of tumor cells). The expression of p63 and p40 was detected in 4 (20%) and 2 (10%) of twenty adenocarcinoma cases, and the extent of staining was all focal (≤25% of tumor cells). The p63 reactivity showed 100% sensitivity, 80% specificity, 71% positive predictive value, and 100% negative predictive value for the differentiation of SCC from adenocarcinoma in malignant effusions. The sensitivity of p40 for SCC was 100%, the specificity was 90%, the positive predictive value was 83%, and the negative predictive value was 100%.

Conclusion:

Although p63 and p40 are both useful markers for the diagnosis of SCC in malignant effusions, p40 is more specific than p63 in distinguishing SCC from adenocarcinoma.
Variasi Konsentrasi Air Limbah Proses Pencucian Pulp pada Membraneless Air Cathode Microbial Fuel Cell
Authors: Wardhana Krisna Adhitya , Effendi Agus Jatnika
Published: June 2020

Membraneless-Microbial Fuel Cell (ML-MFC) satu kompartemen dengan katoda kontak udara saat ini sedang dikembangkan dan menjadi alternatif solusi untuk sumber energi terbarukan yang mampu menghasilkan listrik dari proses degradasi substrat. MFC membutuhkan substrat yang kaya senyawa organik seperti air limbah dari proses pencucian pulp. Pada air limbah ini terdapat lindi hitam dalam kondisi terencerkan yang mengandung lignin dan kaya senyawa organik sehingga memiliki potensi untuk digunakan sebagai substrat dalam reaktor MFC. Selain itu, penggunaan substrat berupa air limbah industri memiliki efek yang baik terhadap lingkungan karena berkontribusi dalam pengurangan kontaminan. Penelitian ini bertujuan untuk mengetahui pengaruh konsentrasi awal Chemical Oxygen Demand (COD) air limbah pencucian pulp sebagai substrat terhadap arus dan voltase listrik yang terjadi dalam MFC. Dalam penelitian ini, reaktor MFC mengolah air limbah pencucian secara batch dengan 4 variasi konsentrasi COD yaitu 613 mg/L, 833 mg/L, 940 mg/L, dan 1620 mg/L dengan pH 8,91 - 10,03. Hasil penelitian menunjukkan MFC mampu mereduksi COD air limbah pencucian pulp sebesar 34 - 48%. Terkait potensi listrik, akumulasi arus listrik yang terjadi pada MFC sebesar 12,67- 39,17 mA/m2 pada kisaran voltase tertinggi dari 4 reaktor sebesar 214 - 287 mV. The Concentration Variation of Wastewater From Pulp Washing Process in Membraneless Air Cathode Microbial Fuel CellA one compartment Membraneless-Microbial Fuel Cell (ML-MFC) with an air cathode was recently developed and became alternative solution for renewable energy sources to generate electricity from substrate degradation. MFC needs proper substrate that was rich in organic content such as wastewater from pulp washing process. The wastewater contains black liquor that was already diluted and contains lignin and high organic content, so that it would be potential as MFC substrate. Furthermore, the utilization of industrial wastewater as substrate can contribute positive effect to the environment namely contaminant reduction. This research was conducted to understand the effect of initial Chemical Oxygen Demand (COD) concentration of wastewater from pulp washing process to electricity current and voltage occured from MFC. The wastewater from pulp washing process with 4 initial COD concentrations (61, 833, 940, and 1620 mg/L) and pH ranged from 8,91 to 10,03 were batch treated in a batch system using the MFC. The results showed that 34-48% COD removal can be performed by MFC. Related with electricity potency from MFC, electricity accumulation current happened on 12,67 mA/m2 - 39,17 mA/m2 at highest voltage from 4 reactors of 214-287 mV.
Analisis Mutu Proses Produksi Kertas Dupleks dengan Mempertimbangkan Waktu Kerusakan untuk Meminimumkan Biaya Cacat
Authors: Widayanti Asti , Rostika Ike
Published: June 2020

Penelitian ini menganalisis kualitas proses produksi kertas dupleks yang diproduksi PT.X paper mill dan menentukan waktu pemeliharaan optimum yang meminimumkan biaya cacat, dengan identifikasi proses produksi dominan penyebab cacat menggunakan Statistical Process Control (SPC). Tahapan yang paling dominan dalam terjadinya cacat pada proses produksi kertas dupleks paper machine 3 adalah proses coating yang mengakibatkan kerugian bagi perusahaan sebesar 32,96% atau Rp893.140.000,00. Cacat pada proses coating disebabkan faktor bahan, mesin, operator dan pengukuran pengujian, denganfaktor mesin berkontribusi terbesar yaitu 81,50%. Waktu antar kerusakan pada proses coating memiliki model proses posson non homogen model power law dengan rata-rata 4 jam. Waktu pemeliharaan pencegahan optimum mesin coating adalah setelah mesin beroperasi 199,32 jam dengan resiko biaya Rp13.719.929,00. Resiko biaya ini senilai Rp602.983.033,00 setahun atau mengurangi biaya cacat pada proses coating Rp290.156.967,00.  Analysis Quality of Production Process Duplex Paper by Considering Failure Time to Minimize Failure CostAbstractThis research analyzing the quality of the PT. X duplex paper production process and determine the optimum maintenance time that can minimize failure cost, through identification of the dominant production process that causes defects by using the Statistical Process Control (SPC). Coating process are the most dominant stages in the occurrence of defects in the duplex paper machine 3, which resulted in a loss for the company of 32.96% or Rp893,140,000.00. Defects in the coating process are caused by material, machine, operator and test measurements, with machine factor as the largest contributor by 81.50%. The time between failure in the coating process have non-homogeneous posson process, power law model with a mean time of 4 hours. The optimum preventative maintenance time for a coating machine is after a 199.32 hour operation with a risk of Rp13,719,929.00. This cost risk is Rp602,983,033.00 a year or reduce the defects cost in the coating process by Rp290,156,967.00.
Prediksi Volatilitas Harga Jual Produk Pada E-Commerce untuk Independent Stockashtic Data Menggunakan Simulasi Monte Carlo
Authors: Setyawan Erlangga Bayu , Novitasari Nia , Muttaqin Prafajar Suksessanno
Published: June 2020

Perkembangan dan penggunaan inovasi teknologi tersebut juga telah mengubah perilaku masyarakat dari masyarakat industri menuju masyarakat informasi. Perubahan tersebut dapat terlihat dengan adanya peningkatan pola konsumsi masyarakat dari perdagangan melalui toko fisik (offline) beralih ke perdagangan melalui sistem elektronik atau sering disebut sebagai e-commerce. Jasa logistik merupakan pemeran distribusi di lini downstream dimana bertugas untuk mengantarkan produk dari fulfillment center dari suatu e-commerce menuju ke end customer. Jasa logistik dituntut harus dapat melakuan pemenuhan permintaan dari konsumen sesuai dengan service level agreement (SLA). Tidak menentunya jumlah permintaan menjadi tantangan yang paling besar bagi pemeran jasa logistik. Seperti studi kasus yang digunakan pada penelitian ini, PT ABC mengalami overload ketika melakukan pemenuhan permintaan dari e-commerce PT XYZ. Overload tersebut dikarenakan ketidaksiapan PT ABC dalam menangani lonjakan permintaan yang signifikan karena perubahan harga jual Produk A di e-commerce PT XYZ. Pada penelitian ini diusulkan model peramalan harga jual Produk A pada e-commerce PT XYZ menggunakan model Simulasi Monte Carlo Independent Variable. Simulasi dilakukan dengan 1.000 percobaan dan menghasilkan MAPE terendah pada percobaan 322, yaitu, 0,122%.
ACCURACY OF THE TRANSLATION OF CULTURAL WORDS IN THE MAZE RUNNER NOVEL INTO INDONESIAN LANGUAGE
Authors: Anindya Widya Dara , Sutrisno Adi , Poedjosoedarmo Soepomo , Ricahyono Sigit
Published: June 2020

There have been plenty of studies on translation accuracy, but that focusing on cultural words under-investigated. The current study investigated the translation accuracy of The Maze Runner Novel in English by James Dashner into Indonesian by Yunita Candra.  As many as 11 cultural words were collected. To measure the accuracy, questionnaires were distributed to 12 translators of at least 1 year of professional experience.  The taxonomy developed by Pelawi (2014) covering categories of accurate (Ak), less accurate (KAk), and not accurate (TAk) was applied. Results show that (Ak) occurs 7/64%, (KAk) does 3/27%, and (TAk) does 1/9%. That a number of the data fall into the category of (KAk) and (TAk) indicate that while cultures share common features (universal), at the same time they contain characteristic features that are unique. It goes, therefore, no cultural expressions can be in total accuracy if they are transplanted into other cultures.
Mechanistic Insights on Hypervalent Iodine-Mediated Styrene Hetero- and Homodimerization
Authors: Hussein Aqeel A. , Al-Yasari Ahmed , Ma Yumiao
Published: June 2020

A mechanistic insight into the hetero- and homodimerizations (HETD and HOMD) of styrenes promoted by hypervalent iodine reagents (HVIRs; DMP and PIDA) and facilitated by HFIP to yield all trans cyclobutanes is reported using density functional theory (DFT) calculations. The HFIP molecules lower the energy of the single electron oxidation (SEO) or initiation as a result of strong hydrogen bonding interactions that substantially stabilize the frontier orbitals before and after electron addition. The HETD or HOMD is a radically-characterized π-π stacked head-to-head stepwise [2+2] cycloaddition initiated via SEO by DMP or PIDA, respectively. DFT results supported by quasiclassical molecular dynamics simulations show that HOMD is a competing pathway to HETD although the latter is relatively faster, in accordance with experimental observations. The initiation is a rate-determining step as a thermodynamically endergonic and propagation is accomplished by radically-cationic hetero- and homodimerized intermediate as propagation is faster than single electron reduction (SER) or termination by radically-anionic HVIRs. Initiation by DMP found to be faster and less endergonic than by PIDA due to (1) the energy gap of electron transfer in a SEO step by I(V) is lower than I(III) and (2) the SOMO energy of the radical anion I(V) is lower than I(III). Furthermore, the presence of p-methoxy group is essential to underpin the SEO by which the more thermodynamically favorable SEO leads to a successful cycloaddition as the thermodynamic term represents a major contribution in the initiative barrier.
Polymeric Encapsulation of a Ruthenium Polypyridine Complex for Tumor Targeted 1- and 2-Photon Photodynamic Therapy
Authors: Karges Johannes , Li Jia , Zeng Leli , Chao Hui , Gasser Gilles
Published: June 2020

Photodynamic therapy is a medical technique, which is gaining increasing attention to treat various types of cancer. Among the investigated classes of photosensitizers, the use of Ru(II) polypyridine complexes is gaining momentum. However, the currently investigated compounds generally show poor cancer cell selectivity. As a consequence, high drug doses are needed, which can cause side effects. To overcome this limitation, there is a need for the development of a suitable drug delivery system to increase the amount of PS delivered to the tumor. Herein, we report on the encapsulation of a promising Ru(II) polypyridyl complex into polymeric nanoparticles with terminal biotin groups. Thanks to this design, the particles showed much higher selectivity for cancer cells in comparison to non-cancerous cells in a 2D monolayer and 3D multicellular tumor spheroid model. As a highlight, upon intravenous injection of an identical amount of the Ru(II) polypyridine complex, an improved accumulation inside an adenocarcinomic human alveolar basal epithelial tumor of a mouse by a factor of 8.7 compared to the Ru complex itself was determined. The nanoparticles were found to have a high phototoxic effect upon 1-photon (500 nm) or 2-photon (800 nm) excitation with an eradication of an adenocarcinomic human alveolar basal epithelial tumor inside a mouse. Overall, this work describes, to the best of our knowledge, the first in vivo study demonstrating the cancer cell selectivity of a very promising Ru(II)-based PDT photosensitizer encapsulated into polymeric nanoparticles with terminal biotin groups.
What Is Discoverable and Why We Need Diversity in Science
Authors: Yudin Andrei
Published: June 2020

This essay tackles the topic of what is discoverable by humans and why it is essential to have diversity of cultural, ethnic, and gender backgrounds in science.
Enhanced Densification and Conduction Properties of Li5+xLa3Nb2-xZrxO12 Garnet Solid-State Electrolytes Through Zn Doping on the Nb/Zr Site
Authors: Dong Bo , Li Linhao , Tao Xiao , Stockham Mark P. , Li Chuan , Li Yongliang , Ding Yulong , Slater Peter
Published: June 2020

While garnet Li ion conductors are attracting considerable interest as potential solid state electrolytes for Li ion batteries, a key challenge is to improve the conductivity, which is associated with the Li content in the structure, and to overcome the challenges of sintering dense electrolyte membranes. In this work we show that Zn doping on the 16a octahedral Nb site leads to substantially improved sintering in both Li5La3Nb2O12 and Li6La3ZrNbO12. As a result of the enhanced sintering, and the associated increase in Li content, the conductivities in both garnet systems were significantly enhanced on Zn doping, up to 2.1 x 10-4 Scm-1 at 25 oC for Li6.6La3ZrNb0.8Zn0.2O12. This doping strategy therefore represents a promising approach to improve the relative density and, hence, ionic conductivity of garnet solid state electrolyte materials for possible solid-state battery applications.
Microstructural Control of Polymers Achieved Using Controlled Phase Separation During 3D Printing with Oligomer Libraries: Dictating Drug Release for Personalized Subdermal Implants
Authors: Ruiz-Cantu Laura , Trindade Gustavo , Taresco Vincenzo , Zhou Zuoxin , Burroughs Laurence , Clark Elizabeth , R. A. J. Rose Felicity , Alexander Morgan , Tuck Christopher , Hague Richard , Roberts Clive , Irvine Derek , Wildman Ricky
Published: June 2020

Controlling the microstructure of materials by means of phase separation is a versatile tool for optimizing material properties. In this study, we show that ink jet 3D printing of polymer blends gives rise to controllable phase separation that can be used to tailor the release of drugs. We predicted phase separation using high throughput screening combined with a model based on the Flory-Huggins interaction parameter, and were able to show that drug release from 3D printed structures can be predicted from observations based on single drops of mixtures. This new understanding gives us hierarchical compositional control, from droplet to device, allowing release to be ‘dialed up’ without any manipulation of geometry. This is an important advance for implants that need to be delivered by cannula, where the shape is highly constrained and thus the usual geometrical freedoms associated with 3D printing cannot be exploited, bringing a hitherto unseen level of understanding to emergent material properties of 3D printing.
SANATTA DİYALOG RESİMDEN HEYKELE
Authors: GİRGİN Figen
Published: June 2020

Sanatçı; doğa ve insanın yanı sıra, sanat yapıtları ile de ilişki içerisindedir. Daha önce yapılmış olan, başka bir sanatçı ve onun eserleri için esin kaynağı olabilir. Sanatçının kurduğu bu diyaloğun altında, geçmişe duyulan özlem ve ilginin yanı sıra, onda görülmemiş olanı keşfetme, daha önce yapılmış olanı yeni bir bakış açısı ile yorumlayarak tazeleme düşüncesi ve ondan yeni bir öykü var etme isteği de yatmaktadır. Bazı sanatçılar ise tüm bunların dışında, sadece geçmişi yağmalamaktan büyük bir haz duydukları için bunu yaparlar. Geçmişteki biçimlerin kullanılmasına ve bunun bilinçli olarak yapılmasına özellikle çağdaş sanatta sıklıkla rastlanmaktadır. Bazen bir sanat eseri belirgin biçimde bazen ise çağrıştırıcı düzeyde, kendinden bir parçayı başka bir sanat eserine aktarır. Sanatta kurulan bu türden diyaloglar sadece yapıtlar ile sınırlı değildir. Yapıtlar arasında olan bu diyalog, farklı sanat dalları arasında da kendini göstermektedir. Tıpkı resimden heykele olduğu gibi. Fırça ve boya kullanılarak ustalıkla yapılmış resimler, ahşap, taş, bronz döküm, fiberglas, polyester gibi malzemelerle; bazen keskin, sert hatları ve dokulu yüzeyi ile kendini biçime teslim ederken bazen ise yumuşak geçişli pürüzsüz yüzeyi ve gerçekçi görünümü ile heykelde yeni bir boyut kazanır. Bir anlamda, resmin ruhu heykele geçer. Eski, yenide tekrar hayat bulur ve izleyici tarafından hatırlanmayı ve tanınmayı bekler.Bu araştırmada, heykelin resim ile olan ilişkisi incelenip, sanatçıların heykellerinde esin kaynağı olarak seçtikleri resimler aracılığıyla nasıl yaratıcı bir sürece, diyaloğa girdikleri, resmin özündeki estetik değerleri nasıl iki boyuttan üç boyuta aktardıkları; Ann Hirsch, Anthony Caro, Seward Johnson, Juan Muñoz, Rebecca Szeto, Julie Rrap, Yinka Shonibare ve Robert Arneson gibi sanatçıların yapıtlarından verilen örneklerle açıklanmaya çalışılmıştır. Sanatçıların bu yapıtları esin kaynağı olarak seçme nedenleri, onları nasıl yorumladıkları ve sergiledikleri soruları; var olan ve yeniden üretilen yapıtın ve geçmişin, bugünün sanatına nasıl yansıdığının anlaşılmasını sağlayacaktır.
Counterstories, Stock Characters, and Varieties of Narrative Resistance
Authors: Lance Mark
Published: June 2020

Abstract here.
The Eligibility of Rule Utilitarianism
Authors: Mokriski David
Published: June 2020

According to the eligibility theory of meaning, often attributed to David Lewis, the referent of a predicate is the property that best balances the twin constraints of charity (i.e. fit with our usage of the term) and eligibility, where eligibility is a function of metaphysical naturalness (i.e. how much of a natural kind the property is). This sort of metasemantics, which is motivated by its ability to resolve problems of indeterminacy and secure shared reference between disputing parties, can be somewhat friendly towards revisionary (i.e. counterintuitive) theories, since highly natural properties can act as “reference magnets,” securing our reference despite some mismatch with usage. In this paper, I apply these considerations to normative ethics and argue that the theory of rule utilitarianism achieves a high balance of charity and eligibility. I proceed by comparing rule utilitarianism to two of its well-known rivals, act utilitarianism and Rossian pluralism (a.k.a. “Commonsense Morality”). I show how the former achieves a high degree of eligibility but only at a significant cost of charity, while the latter does the opposite, fitting very nicely with our considered judgments but at the price of very low eligibility. Rule utilitarianism, on the other hand, strikes a good balance between these extremes; it assigns to our core moral term (‘moral permissibility’) a relatively natural property without doing too much damage to our moral convictions. Thus, rule utilitarianism should be regarded as a promising moral theory by any philosopher who takes seriously considerations of eligibility and naturalness.
Review of Kent Fedorowich and Andrew S. Thompson (eds.), Empire, Migration and Identity in the British World
Authors: Wallace Valerie
Published: June 2020

No description supplied
Specifying the corpus of secondary legislation subject to publication, presentation and disallowance
Authors: Knight Dean
Published: June 2020

This note explains important changes to the definition of secondary legislation for parliamentary oversight purposes.
Eventos extremos de precipitação no Estado de Minas Gerais associados com a ocorrência de episódios de Zona de Convergência do Atlântico Sul
Authors: Silva Paola Nascimento , Escobar Gustavo Carlos Juan , Reboita Michelle Simões
Published: June 2020

Esse estudo teve como objetivo identificar os eventos extremos de precipitação diária na mesorregião metropolitana de Belo Horizonte (MG) em dias de ocorrência de Zona de Convergência do Atlântico Sul (ZCAS). Para tanto, utilizaram-se uma base de dados de episódios de ZCAS e dados diários de precipitação de 3 estações meteorológicas no período de outubro de 2006 a abril de 2017. Foram encontrados 15 casos de chuva extrema na mesorregião metropolitana de Belo Horizonte. Com essa informação, foram elaborados campos compostos e de anomalias para identificar as características sinóticas da atmosfera em eventos com precipitação extrema em relação à climatologia dos eventos de ZCAS. Entre as principais características encontradas nas composições destaca-se a presença de anomalias negativas de pressão ao nível médio do mar e de altura geopotencial em 500 hPa, a oeste da anomalia em superfície, o que é indicativo de um sistema de baixa pressão e de um cavado em níveis médios/altos mais profundos nos dias com eventos extremos de chuva e que podem ser cruciais na canalização de umidade da Amazônia para o Sudeste do Brasil.
Reference Evapotranspiration in the State of Paraíba, Brazil: Climatic Trends and Influencing Factors
Authors: Nascimento Robson de Sousa , Brito José Ivaldo Barbosa de , Borges Valéria Peixoto , Borges Péricles de Farias , Araújo Lázaro de Souto
Published: June 2020

Reference evapotranspiration (ET0) plays an important role in the planning of irrigation and the water demand of crops, as well as in the planning of water uses in watershes. The identification of trends in ET0 under climate changes is important to understand its effects on agriculture, water balance and water resources planning. The goal of this work was verify whether there was or there was not an increasing/decreasing trend on ET0 in dry and rainy periods, as well as in annual period, identifying the influencing climate variables on ET0 in the state of Paraíba, Brazil. In order to determine the ET0 trend in the series the Mann-Kendall nonparametric test was used, whereas the series slope was determined by applying Sen’s estimator. To identify the most influencing clilmatic variable it was performed a multiple regression of normalized data. The data were obtained of six stations with monthly data from January 1961 to December 2015, a total period of 55 years. Results showed increasing on ET0 in almost all stations during the study period, except for a single of them in which there was a decreasing. The most dominant variables influencing the trend on ET0 was air temperature during annual time scale, while during the rainy and dry seasons there was an alternation between the most influencing variables (air temperature and sunshine duration).
Uso de Técnicas de Geoprocessamento para Estudo da Erosão Hídrica Laminar em Bacia Hidrográfica do Sudoeste do Paraná.
Authors: Tomazoni Julio Caetano , Vansan Ana Paula
Published: June 2020

Este trabalho tem como objetivo avaliar a erosão hídrica laminar do solo, por meio da Equação Universal de Perdas de Solos Revisada (RUSLE) na bacia hidrográfica do rio São José, localizada no município de Francisco Beltrão (PR).  A perda de solo média anual (A) foi determinada através da RUSLE para os anos 2000, 2005, 2009, 2015 e 2017 utilizando-se técnicas de geoprocessamento com o auxílio do software ArcGis 10.0. O fator erosividade da chuva (R) foi determinado utilizando-se dados pluviométricos correspondentes ao período de 1974 a 2016. O fator erodibilidade do solo (K) foi obtido através da análise de amostras de solo coletadas in loco. O fator topográfico (LS) foi estimado por meio dos dados altimétricos e hidrográficos da bacia. Os fatores de uso e manejo do solo (C) e de práticas conservacionistas do solo (P) foram determinados por meio da caracterização multitemporal do uso e ocupação do solo, através de imagens de satélite. O potencial natural de erosão (PNE) foi determinado pela multiplicação dos fatores R, K e LS.A estimativa de perda de solo (A) foi determinada pela multiplicação do PNE pelos fatores C e P.  Use of Geoprocessing Techniques to Study Laminar Water Erosion in Watershed of Southwest Paraná A B S T R A C TThe objective of this work is evaluate the soil erosion by the Universal Equation of Soil Losses Revised (RUSLE) in the São José river basin, located in the municipality of Francisco Beltrão (PR). The average annual soil loss (A) was determined through RUSLE for the years 2000, 2005, 2009, 2015 and 2017 using geoprocessing techniques with ArcGis 10.0 software. Rainfallerosivity (R) was determined using rainfall data from 1974 to 2016, being determined at 11521.26 11521,26 MJ.mm.ha-1.h-1.year-1. The soil erodibility factor (K) was obtained through the analysis of soil samples collected on the spot (0,03018 t.ha.h/ha.MJ.mm, 0,02771 t.ha.h/ha.MJ.mm e 0,02342 t.ha.h/ha.MJ.mm). The topographic factor (LS) was estimated by the altimetric and hydrographic data of the basin. Soil use and management (C) and soil conservation (P) were determined through multitemporal characterization of land use and occupation, using satellite images. The natural erosion potential (NEP) was determined by multiplying the R, K and LS factors, with more than half of the total area of the watershed with very strong PNE. The soil loss estimate (A) was determined by multiplying the NEP by factors C and P with predominance of the class called low (0 to 10 t/ha/year) denoting the reduction of erosion rates through factors C and P, helping to protect the soil from the erosion process.Key words: Soil Erosion; Watershed, Revised Universal Soil Loss Equation, Geoprocessing, Software.
Modelagem espacial de áreas suscetíveis a inundações baseada em um modelo multicritério hibrido e Sistema de Informação Geográfica: um estudo de caso aplicado a bacia do Rio Bengalas
Authors: Freiman Fabiano Peixoto , Carvalho Camila de Oliveira
Published: June 2020

A identificação de áreas suscetíveis a inundações é essencial para o gerenciamento de desastres e definição de políticas públicas. O objetivo deste trabalho é a apresentação de um método para identificação de áreas suscetíveis a inundações através da integração de informações geográficas provenientes de técnicas do Sensoriamento Remoto, as ferramentas do Sistema de Informação Geográfica (SIG), a lógica Fuzzy e a aplicação de Métodos de Análise Multicritério (MAM) Analytical Hierarchy Process (AHP). Para atingir o objetivo foi proposto um estudo de caso, localizado na Bacia do Rio Bengalas, nos municípios de Nova Friburgo e Bom Jardim (Região Serrana do Rio de Janeiro). A modelagem espacial multicritério foi realizada a partir da seleção de um conjunto de dados composto por informações geomorfológicas, hidrológicas e de uso e ocupação do solo. Como resultado, obteve-se um mapa de suscetibilidade a inundações para a região. A coerência do modelo gerado foi verificada a partir do histórico de inundações da bacia do Rio Bengalas. A metodologia, apresentou-se eficiente e adequada para a determinação de áreas suscetíveis a inundações, prevendo com sucesso a distribuição espacial de áreas com riscos a inundações.  Spatial modelling of flood-susceptible areas based on a hybrid multi-criteria model and Geographic Information System: a case study applied to the Bengalas River basin A B S T R A C TThe identification of areas susceptible to flooding is essential for disaster management and public policy making. The objective of this work is the presentation of a method for the identification of areas susceptible to floods through the integration of geographic information from Remote Sensing techniques, Geographic Information System (GIS) tools, Fuzzy logic and the application of Multicriteria Analysis Methods (MAM) Analytical Hierarchy Process (AHP). In order to achieve the objective, a case study was proposed, located in the Bengalas River Basin, in the municipalities of Nova Friburgo and Bom Jardim (Mountain Region of Rio de Janeiro). Multicriteria spatial modeling was performed by selecting a data set composed of geomorphological, hydrological and land use information. As a result, a flood susceptibility map was obtained for the region. The coherence of the generated model was verified from the flood history of the Bengalas River basin. The methodology was efficient and adequate for the determination of areas susceptible to floods, successfully predicting the spatial distribution of areas at risk of flooding.Keywords: flood susceptibility. Fuzzy logic. MAM. AHP. GIS.
Da Escassez ao Excesso de Água: um Recorte do Semiárido no Nordeste e Médio Vale do Itajaí no Sul do Brasil
Authors: FERNANDES RAFAELA DIAS , Cavalcanti Ramalho Angela Maria , Rosa Camila Cristina , Mansur de Moraes Souza Cristiane , Mello Bruno Jandir
Published: June 2020

Objetiva-se discutir a problemática das condições de riscos e vulnerabilidades socioambientais nos cenários do Semiárido paraibano e Médio Vale do Itajaí (SC), respectivamente, no Nordeste e Sul do Brasil. Parte-se do pressuposto de que o alcance dos dois problemas emblemáticos de (i) escassez e (ii) excesso de água apresentam riscos sociais e ambientais. Com base em um argumento socioambiental é relevante compreender que a questão da escassez de água no Semiárido nordestino se debruça sobre as questões de acesso e distribuição da água, ocasionando conflitos socioambientais. Enquanto a questão do excesso de água no Vale do Itajaí apresenta um indicador significativo de vulnerabilidade resultante das cheias, deslizamentos e enxurradas na localidade. A metodologia da pesquisa se caracteriza por um diagnóstico descritivo explicativo de caráter exploratório. Os principais resultados apontam para argumentos os quais enfatizam que com o crescente aumento da população urbana em todo o mundo é premente incorporar o conhecimento dos riscos e vulnerabilidades a que esta população está sujeita, e o planejamento para a gestão e gerenciamento da água. Medidas de mitigação e adaptação a estes riscos que aumentem a resiliência socioecológica são evidentemente necessárias e precisam ser incluídas no planejamento e na gestão das cidades. Estas medidas necessitam reforçar a legitimidade nos processos de governança por meio da participação social.  A B S T R A C TThe main purpose of the paper is discuss the risk conditions and social environmental vulnerabilities in the scenarios of the Médio Vale do Itajaí (SC) and Semi-Arid Paraiban, respectively, in the South and Northeast of Brazil.  It is assumed that the scope of the two problems of (i) excess and (ii) water scarcity pose social and environmental risks. Based on a socio-environmental argument it is relevant to understand that the issue of water excess in the Vale do Itajaí presents a significant indicator of social vulnerability resulting from flooding, landslides and floods, the issue of water scarcity in the Northeastern Semi-Arid focuses on the lack of water access and distribution, causing social and environmental conflicts in the communities.  The research methodology is characterized by an exploratory descriptive diagnosis. The main results point out arguments that emphasize that because of the growing urban population worldwide it is urgent to incorporate the knowledge of risks and vulnerabilities to this population, and its correct management. Mitigation and adaptation measures to these risks that increase socio-ecological resilience are obviously necessary and need to be included in city planning and management. These measures need to strengthen legitimacy in governance processes through social participation.Keywords: water management, social and environmental vulnerability, resilience, Paraíba, Vale do Itajaí.
The Effect of Rose Water (Rosa damascena mill) Supplementation in Broiler Rations on Growth Performance, Some Carcass Parameters and Intestinal Histomorphology
Authors: YILDIZ Gültekin , AYDIN Özlem Durna , BAYRAKTAROĞLU Alev Gürol
Published: June 2020

The purpose of this study was to investigate the effect of added to different levels of rose water broiler diets on growth performance, some carcass parameters and intestinal histomorphology. In the literature on the conducted research, there are very few studies about the use of rose water in animal as feed additive. A total of 216 day-old chicks were randomly divided into 3 groups each containing 72 chicks. While the control group was fed with basic ration, the experimental groups were fed with rose water supplementation at 2% and 4% dose, respectively, in addition to the basic ration. At the end of the experiment, the use of rose water in the rations did not statistically affected live weight (LW), live weight gain (LWG) and feed intake (FI) values, but feed conversion ratio (FCR) value was adversely affected. In the study, hot carcass weight was positively affected while some internal organ weights did not affected by the addition rose water. On the 21st and 35th days of the experiment, when histolomorpfology of ileum and jejenum were examined, it was observed that villus height, crypt depth and villus height: crypt depth ratio were not affected by rose water addition. On the 21st day of the study, ileum and jejenum and on the 35th day of the study, ileum villus heights without sitatistical were positively affected by the addition of rose water. In conclusion, hot carcass weight and intestinal health were positively affected by rose water. However, performance and some internal organ weights did not affected.
Pendampingan Ustaż dan Tuan Guru Pesantren Melalui Penguatan Nilai-nilai Multikultural Untuk Mencegah Radikalisme Islam Berbasis Pesantren di Kota Bima
Authors: Ruslan Ruslan , Luthfiyah Luthfiyah
Published: June 2020

Bima city has been called “Red Zone” area for radicalism dissemination. Prior reasearch indicated that the Islamic radicalism in Bima appeared from Islamic institution such as pesantren. This community service aimed at preventing Islamic radicalism in pesantren by sharing, educating and giving reinforcement of multicultural values to ustaż and Tuan Guru Pesantren (TGP). Community-Based Research (CBR) approach was employed because ustaż and TGP are the prior of pesantren’s community who can developed and transfer their understanding and religious perception to the students (santri). The results showed that ustaż and TGP had been more inclusive in their religion understanding, they transformed multicultural values to their student and all of pesantren’s community until this preventive step can prohibit the Islamic radicalism. They were also willing to involve the community service team in composing pesantren’s learning program. The team also give monthly visit for sharing idea about multicultural values.