bluuebunny/crossref_metadata_2025 huggingface dataset:
Stability Studies of a Tetraethyl Orthosilicate-Based Thixotropic Drug Delivery System
Authors: Barrett-Catton Emma , Arrigali Elizabeth M. , Serban Bogdan A. , Sandau Kolton C. , Serban Monica A.
Published: October 2024

Background/Objectives: This study assessed the effects of formulation components on the long-term stability of a previously described tetraethyl orthosilicate-based drug delivery system. Early stability studies of a product concept are crucial not only to provide information on the overall system stability and individual components’ contributions to it, but also to identify opportunities for dosage form optimization and to define its use case. Methods: We assessed the time-dependent thixogel properties—specifically, mechanical strength, thixotropy, release of model drug, and dry substance—in both real-time and accelerated shelf-life determination set-ups. Results: Our findings indicate that the concentration and molecular weight of hyaluronic acid, one of the main constituents of the investigated thixotropic systems, are key determinants of formulation stability. We further showed that changes in both of these parameters reflect on the drug release properties and stiffness of the formulation and could inform subsequent product development based on several use cases. Conclusions: Overall, this study provides an understanding of some key factors that would need to be considered prior to and in the final product development process of thixogels in preparation for commercialization.
MsFtsH8 Enhances the Tolerance of PEG-Simulated Drought Stress by Boosting Antioxidant Capacity in Medicago sativa L.
Authors: Li Ruyue , Zeng Xiangcui , Jiang Xueqian , Long Ruicai , He Fei , Wang Xue , Chen Lin , Yu Qianwen , Kang Junmei , Yang Qingchuan , Yang Tianhui , Liu Zhongkuan , Li Mingna
Published: October 2024

Drought is a major abiotic stress that limits the growth and yield of alfalfa, a vital forage legume. The plant metalloproteinase Filamentation temperature-sensitive H (FtsH) is an ATP- and Zn2+-dependent enzyme that plays a significant character in the plant’s response to environmental stress. However, its functional role in drought resistance remains largely unexplored. This study investigates the drought tolerance role of alfalfa MsFtsH8 by analyzing the growth, physiology, and gene expression of overexpressing plants under drought conditions. The results demonstrated that both MsFtsH8-overexpressing Arabidopsis and alfalfa plants exhibited superior growth condition and enhanced membrane stability. The overexpressing alfalfa plants also showed reduced MDA levels, higher proline content, lower H2O2 accumulation, an increased activity of antioxidant-related enzymes (SOD, POD, and CAT) activity, and an elevated expression of antioxidant-related genes. These results indicated that the overexpression of MsFtsH8 enhanced growth, improved osmotic regulation, reduced ROS levels, and increased antioxidative capacity, ultimately leading to greater drought tolerance in alfalfa. Our findings suggest that MsFtsH8 mitigates oxidative damage caused by drought by modulating the plant’s antioxidant system, thus improving drought tolerance in alfalfa. This study provides a molecular basis and candidate genes for enhancing drought resistance in alfalfa through genetic engineering.
New Antimicrobial Materials Based on Plasticized Polyvinyl Chloride for Urinary Catheters: Preparation and Testing
Authors: Deleanu Iuliana Mihaela , Grosu Elena , Ficai Anton , Ditu Lia Mara , Motelica Ludmila , Oprea Ovidiu-Cristian , Gradisteanu Pircalabioru Gratiela , Sonmez Maria , Busuioc Cristina , Ciocoiu Robert , Antoniac Vasile Iulian
Published: October 2024

Given the constant increased number of nosocomial infections in hospitals, especially associated with prolonged usage of inserted medical devices, our work aims to ameliorate clinical experience and promote faster healing of patients undergoing urinary catheterization by improving the properties of medical devices materials. Within this research, nine different composites were prepared based on polyvinyl chloride, using three different plasticizers (di-(2-ethylhexyl) phthalate, Proviplast 2646, and Proviplast 2755), and two different antimicrobial additives containing silver nanoparticles. The prepared materials were analyzed, and their physicochemical properties were determined: water absorption, relative density, plasticizer migration, hydrophobicity/hydrophilicity by contact angle measurement, Shore A hardness, tensile strength, and elongation at break. Structure and morphology were also investigated by means of FTIR, SEM, and EDX analyses, and thermal (TG-DSC) and biological properties were evaluated. The most important aspects of obtained results are showing that plasticizer migration was significantly reduced (to almost zero) and that the usage of antimicrobial additives improved the materials’ biocompatibility. Thus, based on the concluded favorable properties, the obtained materials can be further used for catheter development. Pressure–flow studies for different sizes and configurations are the next steps toward advanced in vivo and clinical trials.
Key Advances in Solution Blow Spinning of Polylactic-Acid-Based Materials: A Prospective Study on Uses and Future Applications
Authors: Nikolić Nataša , Olmos Dania , González-Benito Javier
Published: October 2024

Solution blow spinning (SBS) is a versatile and cost-effective technique for producing nanofibrous materials. It is based on the principles of other spinning methods as electrospinning (ES), which creates very thin and fine fibers with controlled morphologies. Polylactic acid (PLA), a biodegradable and biocompatible polymer derived from renewable resources, is widely used in biomedical fields, environmental protection, and packaging. This review provides a theoretical background for PLA, focusing on its properties that are associated with structural characteristics, such as crystallinity and thermal behavior. It also discusses various methods for producing fibrous materials, with particular emphasis on ES and SBS and on describing in more detail the main properties of the SBS method, along with its processing conditions and potential applications. Additionally, this review examines the properties of nanofibrous materials, particularly PLA-based nanofibers, and the new applications for which it is thought that they may be more useful, such as drug delivery systems, wound healing, tissue engineering, and food packaging. Ultimately, this review highlights the potential of the SBS method and PLA-based nanofibers in various new applications and suggests future research directions to address existing challenges and further enhance the SBS method and the quality of fibrous materials.
Editorial Introduction, Religions Special Issue, Peace, Politics, and Religion: Volume II
Authors: Haynes Jeffrey
Published: October 2024

In recent years, a burgeoning body of literature on the relationship between peace, politics and religion has emerged [...]
Between the Religious and the Secular: Latin American Neo-Pentecostalism in a Context of Multiple Modernities
Authors: Tec-López René A.
Published: October 2024

This article seeks to understand neo-Pentecostalism in Latin America as a religious and political movement within the framework of multiple modernities, based on an ethnographic study in evangelical churches in Chile and Mexico. The study focuses on two main axes: the discourse of the “Kingdom of God” and the experience of the Holy Spirit. The former explores the conception of public space, while the latter examines the experiential dimensions, both individual and collective, that confer meaning and legitimacy to this religious movement. Neo-Pentecostalism emerges as a complex phenomenon where religion and politics intertwine in novel ways, responding to the intricacies of the region. Contrary to the notion of a monolithic and reactionary movement, this article demonstrates how neo-Pentecostalism is a movement that navigates the interstices between the religious and the secular.
Local Use of Mangroves on the Coast of Southeastern México
Authors: Martínez-Márquez Carlos Alberto , Sol Sánchez Ángel , Zaldívar Cruz Juan Manuel , Sánchez Soto Saúl , Del Rivero Bautista Nydia , Aliphat Fernández Mario Manuel
Published: October 2024

Mangroves are essential for the well-being of the inhabitants of coastal areas, who have extensive knowledge about the use and exploitation of this resource. However, this knowledge is decreasing, which could trigger negative repercussions for this ecosystem. Ethnobiological investigations make it possible to gather information on the use, management, and exploitation of this resource. Hence, this paper presents a study that is framed around the coastal area of the state of Tabasco, in southeast México, and consists of 74 semi-structured interviews that were carried out, while the local relevance of each mangrove species was evaluated using ethnobiological indices. Three species of mangrove were identified, Avicennia germinans, Laguncularia racemosa, and Rhizophora mangle, and the latter species had the highest Use-Value (UV) Index value of 6.08. A total of 27 forms of forestry use were found, 11 for non-timber use and 16 for timber use. Firewood stood out as the main use with 12.6%, while the use of needles to make cloth and crafts represented the lowest percentage with 0.3%. The uses given by the coastal population to the mangroves and their respective species were influenced by immediate needs and specific characteristics of each species. To ensure the sustainability of mangroves, it is essential to design environmental strategies that integrate local ethnobiological knowledge and promote the active participation of direct users of this ecosystem. These strategies should be incorporated into public conservation policies, recognizing the cultural and economic value that mangroves hold for local communities. By implementing these actions, the relationship between communities and their environment will be strengthened, laying the groundwork for further exploration of coastal ethnobiology.
Geodesic-Based Maximal Cliques Search for Non-Rigid Human Point Cloud Registration
Authors: Gan Shuwei , Xu Guangsheng , Zhuge Sheng , Zhang Guoyi , Zhang Xiaohu
Published: October 2024

Non-rigid point cloud registration holds significant importance for human body pose analysis in the fields of sports, medicine, gaming, etc. In this paper, we propose a non-rigid point cloud registration algorithm based on geodesic distance measurement, which can improve the accuracy of the registration for matching point pairs during non-rigid deformations. Firstly, a graph is constructed for two sets of point clouds using geodesic distance measurement considering that geodesic distance changes minimally during non-rigid deformation of the human body, which can preserve the point cloud matching information between corresponding points. Furthermore, a maximal clique search is employed to find combinations of matching pairs between point clouds. Finally, by driving the human body model parameters, sparse matching pairs are overlapped as much as possible to achieve non-rigid point cloud registration of the human body. The accuracy of the proposed algorithm is verified with FAUST and CAPE datasets.
Coalition: Mapping the Development of Inclusive Practices in Initial Teacher Training for Fostering Student Participation
Authors: Fernández-Díaz Elia , San-Miguel-Guerrero Carlota
Published: October 2024

In this article, we present the progress of the Erasmus+ Coalition European project. The aim of this project is to promote the development of inclusive practices in higher education so that optimal learning scenarios can be experienced which allow for the rethinking of participation processes in an educational context. In the first phase of the project, a study was carried out using a mixed methodological approach of teaching competences for the development of inclusive practices. University teaching staff and students from several European institutions participated in this study with the aim of gathering information on the following key areas: academic perceptions of possible institutional obstacles and resources; beliefs of the teaching body with regard to inclusive pedagogical approaches; and strategies for adapting to different learning styles and encouraging student participation. Here, we present the results obtained in relation to the implementation of procedures for inclusive teaching, placing our emphasis on the strategies used to favour the monitoring of student learning. Based on the achievements of the initial stage, our intention is to generate a community of practice that supports the training scaffolding of those concerned, and to develop online processes of inquiry to improve initial teacher training in fomenting student participation.
A Democratic Dilemma: Racial Attitudes, Authoritarianism, and Whites’ Evaluation of Minority Legislators
Authors: Riley Emmitt Y. , Peterson Clarissa
Published: October 2024

The United States prides itself on its immigrant heritage and diversity, yet historically, minority advancements have faced opposition and violence. Little scholarship exists on how whites evaluate minority representation when represented by a minority in a legislative chamber. Prior research suggests that diversity may trigger negative racial and authoritarian attitudes among whites. Given recent political events in the United States and increases in the number of racial minorities running for and winning political office, we investigate white responses to minority representation in the United States Congress. Using the 2022 CES data, we examine how racial and authoritarian attitudes predict whites’ evaluations of Minority House Members. We expand beyond the Black and white binary to include whites’ evaluations of Hispanic legislators and broaden the study of racial attitudes beyond the Racial Resentment index. Our findings demonstrate that whites’ evaluations of minority legislators are linked to racial attitudes and endorsements of policy-based authoritarianism, varying by the representative’s race. White respondents who are in districts that are not represented by a Black or Hispanic legislator exemplify higher levels of racial resentment, disagree that whites have advantages, and agree that racial problems are rare. They also support more authoritarian policies than in districts represented by a Black Representative. White respondents’ approval of minority legislators relies on authoritarian policies and racial attitudes when the member of Congress is Black or Hispanic. In these districts, white respondents who disapprove of their Congressmember have more racial resentment, disagree that whites have advantages, and support more authoritarian policies than white respondents who approve of their Congressmember. This research provides insights into the complexities of minority political representation and its connection to policy-based authoritarianism, as well as its implications for American democracy.
The Relationship Between a Campus Food Pantry and Academic Success at a Public University
Authors: Fergus Linda , Gao Di , Gilbert Kathleen , Lopez Tabbetha
Published: October 2024

Food insecurity (FI) is associated with lower academic performance in university students. This research aimed to describe the relationship between a campus food pantry and academic performance, describe the characteristics of student pantry shoppers (PSs), and develop a model to predict academic success. Researchers obtained student pantry swipes and university data (2021–2022 academic year) to generate a dataset for grade point average (GPA) (N = 23,896) and a subset of PS sociodemographic data (N = 852). Variables (cumulative or term GPA) differed based on models. Explanatory variables were biological sex, age, frequency of pantry shopping, classification, Pell Grant eligibility, college, athlete status, citizenship, residency, ethnicity/race, honors, and first-generation status. The analysis included the two-sample t-test, logistic and multiple regression, and the least absolute shrinkage and selection operator (LASSO). There was no difference (t(921.8) = 0.518, p = 0.60) in the cumulative GPA between PSs (M = 3.001 [0.808]) and non-pantry shoppers (NPSs) (M = 3.016 [0.874]). In the fall term, PSs (M = 3.018 [1.012] earned a higher GPA (t(581.69) = −2.235, p = 0.03) than NPSs (M = 2.919 [1.123]). Pantry shoppers achieved academic success despite exhibiting risk factors for FI, including first-generation status, being of the female sex, and financial need. Targeted multicomponent campus programs are needed to provide food assistance to students at risk for FI.
Lake Restoration Improved Ecosystem Maturity Through Regime Shifts—A Case Study of Lake Baiyangdian, China
Authors: Li Hongxiang , Jin Lei , Si Yujie , Mu Jiandong , Liu Zhaoning , Liu Cunqi , Zhang Yajuan
Published: October 2024

Lake ecosystems are impacted by anthropogenic disturbances and have become vulnerable worldwide. Highly disturbed lake ecosystems are not well understood due to the lack of data on changes in the structures and functions of ecosystems. In this paper, we focus on Lake Baiyangdian (BYDL), the largest shallow lake in North China. Following the establishment of the Xiong’an New Area (XNA) in 2017, concerted efforts to restore BYDL’s aquatic environment have been undertaken, which has led to significant changes in the structures and functions of the ecosystems. We evaluated the biomass dynamics of main biological communities and detected the regime shifts of environmental factors in BYDL from 2016 to 2023. Further, we constructed a food web model for the BYDL ecosystem in 2023 by using Ecopath with Ecosim (EwE) and made a comparison with the reported results in 2018. The results showed significant changes in the ecosystem structure of BYDL over the last 6 years. In 2023, the submerged macrophytes biomass in the system increased by 4.2 times compared to 2018, leading to an increase in total system throughput. We found that BYDL changed from an algal-type lake to a macrophyte-dominated lake. In addition, we found TN, NH4+-N, and CODMn were significantly decreased in BYDL during the restoration. TN and NH4+-N had a change point in approximately 2021, indicating that a regime shift had occurred during restoration. Overall, the BYDL ecosystem was in an immature but developing state, as indicated by ecological network analysis indicators. Nutrient-loading reduction, hydrological regulation, and rational biomanipulation may be the potential driving factors of change in the BYDL ecosystem. We strongly recommend the timely harvesting of submerged macrophytes, the proliferation and release of herbivorous fishes, and the assessment of the ecological capacity of carnivorous fishes in the future ecological restoration of BYDL.
Resilient Sustainability Assessment Framework from a Transdisciplinary System-of-Systems Perspective
Authors: Bataleblu Ali Asghar , Rauch Erwin , Cochran David S.
Published: October 2024

The vital role of extensive information exchange among stakeholders across diverse sectors and the interconnection of various scientific fields with nonhomogeneous technology readiness levels has created a new form of a complex engineering problem in the climate change era. Comprehensive sustainability assessment to enable the realization of needs requires transdisciplinary thinking to achieve systematic solutions that bridge the gap between multiple collaborative systems in a portfolio. Although the principal aim of dedicated sustainability regulations is to force companies to move toward sustainability development, general and non-engineered metrics that have not defined clear thresholds for evaluation have encountered severe challenges regarding implementation and economic viability. Therefore, adopting a transdisciplinary systems engineering approach can address multifaceted challenges like sustainability by overcoming collaboration barriers, and traditional disciplinary limits. This paper systematically reviews sustainability-dictated regulations from a transdisciplinary perspective. Different standards are compared, raised opportunities and challenges are discussed, and future remarks are highlighted. The sustainability problem is analyzed from a transdisciplinary systems engineering lens. Finally, a two-level resilient system sustainability assessment framework is proposed to effectively handle and enhance the resilience of companies’ sustainability development roadmaps by enabling decision makers to find robust and highly reliable solutions regarding sustainable system design. The impact of this research is to create a new insight into addressing climate change which not only assesses the current situation but also considers uncertainty sources that affect decision making for the future.
Scientific and Regulatory Lessons Learnt on Building a Chemistry, Manufacturing, and Controls (CMC) Package for COVID-19 Variant Vaccine Updates in the EU—A Regulator’s Perspective
Authors: Shivji Ragini , Grabski Elena , Jekerle Veronika
Published: October 2024

During the COVID-19 pandemic, eight COVID-19 vaccines were authorised in the European Union (EU); as a result of emerging SARS-CoV-2 variants and waning immunity, some of these have been adapted to broaden the immunity against circulating variants. The pace at which variants emerge challenges the technical feasibility to make adapted vaccines available in a suitable timeframe and in sufficient quantities. Despite the current absence of a clear-cut seasonal spread for COVID-19, the EU regulatory approach thus far is a pragmatic approach following a pathway similar to that of seasonal influenza. This approach currently requires chemistry, manufacturing, and controls (CMC—the design, development and consistent manufacture of a specified medicinal product of good quality) and non-clinical data (from product laboratory and animal studies), as well as demonstrating that updated vaccines induce an immune response that can predict clinical efficacy and safety in humans. For CMC data, COVID-19 mRNA vaccine adaptations generally made use of the same formulation, control strategy, manufacturing process, and inclusion of registered manufacturing sites for the drug product; therefore assessment was generally streamlined. The experience gained from the vaccine adaptations, combined with a continuous early regulator-developer scientific discussion, permits increasingly greater predictability for timing and positive regulatory outcomes. Here, we review key aspects of the quality control and manufacture of updating COVID-19 vaccines to protect against new variants. Although most experience has been gained with mRNA vaccines, we note that investment in the streamlining of manufacturing processes for recombinant protein vaccines would facilitate future strain updates/adaptations thereby safeguarding availability of different COVID-19 vaccine types, which is considered of value for public health. We also reflect on the challenges and opportunities in establishing more predictable regulatory mechanisms for future COVID-19 vaccine adaptions and more widely for future vaccines containing rapidly evolving pathogens with the potential to cause health threats.
Incorporating Recursive Feature Elimination and Decomposed Ensemble Modeling for Monthly Runoff Prediction
Authors: Ma Wei , Zhang Xiao , Shen Yu , Xie Jiancang , Zuo Ganggang , Zhang Xu , Jin Tao
Published: October 2024

Monthly runoff prediction is crucial for water resource allocation and flood prevention. Many existing methods use identical deep learning networks to understand monthly runoff patterns, neglecting the importance of predictor selection. To enhance predictive accuracy and reliability, this study proposes an RFECV–SSA–LSTM forecasting approach. It iteratively eliminates predictors derived from SSA decomposition and PACF using recursive feature elimination and cross-validation (RFECV) to identify the most relevant subset for predicting the target flow. LSTM modeling is then used to forecast flows 1–7 months into the future. Furthermore, the RFECV–SSA framework complements any machine-learning-based runoff prediction method. To demonstrate the method’s reliability and effectiveness, its outputs are compared across three scenarios: direct LSTM, MIR–LSTM, and RFECV–LSTM, using monthly runoff historical data from Yangxian and Hanzhong hydrological stations in the Hanjiang River Basin, China. The results show that the RFECV–LSTM method is more robust and efficient than the direct LSTM and MIR–LSTM counterparts, with the smallest number of outliers for NSE, NRMSE, and PPTS under all forecasting scenarios. The MIR–LSTM approach exhibits the worst performance, indicating that single-metric-based feature selection may eliminate valuable information. The SSA time–frequency decomposition is superior, with NSE values remaining stably around 0.95 under all scenarios. The NSE value of the RFECV–SSA–LSTM method is greater than 0.95 under almost all forecasting scenarios, outperforming other benchmark models. Therefore, the RFECV–SSA–LSTM method is effective for forecasting highly nonlinear runoff series, exhibiting high accuracy and generalization ability.
Multi-Index Approach to Assess and Monitor Meteorological and Agricultural Drought in the Mediterranean Region: Case of the Upper Oum Er Rabia Watershed, Morocco
Authors: Mliyeh Mohammed Mouad , Ait Brahim Yassine , Koutsovili Eleni-Ioanna , Tzoraki Ourania , Zian Ahmed , Aqnouy Mourad , Benaabidate Lahcen
Published: October 2024

Drought is a severe disaster, increasingly exacerbated by climate change, and poses significant challenges worldwide, particularly in arid and semi-arid regions like Morocco. This study aims to assess and monitor drought using a multi-index approach to provide a comprehensive understanding of its spatio-temporal dynamics at both meteorological and agricultural levels. The research focuses on the Upper Oum Er Rabia watershed, which spans 35,000 km2 and contributes approximately a quarter of Morocco’s renewable water resources. We propose a methodology that combines ERA5 temperature data from remote sensing with ground-based precipitation data to analyze drought characteristics. Three meteorological indices were utilized: the Standardized Precipitation Index (SPI), the Standardized Precipitation Evapotranspiration Index (SPEI), and the Reconnaissance Drought Index (RDI). Additionally, three remote-sensing indices were employed to capture agricultural drought: the Normalized Difference Vegetation Index (NDVI), the Enhanced Vegetation Index (EVI), and the Crop Water Stress Index (CWSI), with a total of 528 NDVI and EVI images and 1016 CWSI images generated through Google Earth Engine (GEE), using machine-learning techniques. Trend analyses were conducted to monitor drought patterns spatio-temporally. Our results reveal that the three-month interval is critical for effective drought monitoring and evaluation. Among the indices, SPEI emerged as the most effective for capturing drought in combination with remote-sensing data, while CWSI exhibited the highest correlation with SPEI over the three-month period, outperforming NDVI and EVI. The trend analysis indicates a significant precipitation deficit, alongside increasing trends in temperature and evapotranspiration over both the short and long term. Furthermore, all drought indices (SPI, SPEI, and RDI) demonstrate an intensification of drought conditions. Adaptation strategies are essential for managing water resources in the Upper Oum Er Rabia watershed under these evolving climate conditions. Continuous monitoring of climate variables and drought indices will be crucial for tracking changes and informing future water management strategies.
Trabajo decente y equidad de género en las labores de cuidado en salud no remunerado en Latinoamérica: propuesta de matriz de caracterización, caso Colombia
Authors: Riaño Casallas Martha Isabel
Published: October 2024

Colombia, y por extensión gran parte de Latinoamérica, presenta una carencia significativa de datos precisos y desglosados para muchos de los problemas sociales que le aquejan; entre ellos se incluye el trabajo de cuidado en salud no remunerado, que en la región realizan en un 73% las mujeres, en todos los países y grupos de edad (CEPAL, 2022). En este artículo se esboza una matriz de caracterización que identifica las variables asociadas al trabajo de cuidado en salud no remunerado en los hogares colombianos, desde una perspectiva de trabajo decente y de equidad de género. A continuación, se propone la implementación de herramientas de Tecnología de la Información y Comunicación (TIC) con el objetivo de obtener datos precisos que permitan visualizar esta problemática, de forma integral y contextual, para llegar a soluciones puntuales aplicadas desde las políticas públicas, intervenciones en el sector privado y/o comunitario y, asimismo, desde la toma de las decisiones en cada hogar.
HUBUNGAN KARAKTERISTIK KADER KESEHATAN TERHADAP KUNJUNGAN PASIEN DALAM PENCEGAHAN PENULARAN TUBERKULOSIS PARU
Authors: Amirah Asriwati , Suarayasa Ketut , Imran Herry , Sipayung Patrice Armando
Published: October 2024

One effort to increase visits to pulmonary tuberculosis patients is by finding cases and tracking officers by increasing the role of cadres. The study aimed the relationship of health cadre characteristics to patient visits in preventing pulmonary tuberculosis transmission. In order to examine the relationship between cadre activity factors and tuberkulosis paru patient visits in the prevention and transmission of tuberkulosis paru disease, this type of research employs cross-sectional methodology and quantitative research methods. The population in this study was 110 cadres at the Panombeian Panei Community Health Center. The sampling technique used in this study was a total sampling technique. The research sample consisted of 110 cadres. The bivariate test uses the Chi-Square Test. The results of the study showed that there was a relationship between knowledge (0.003), attitude (0.002), and visits by pulmonary tuberkulosis paru patients. knowledge, attitudes, and activities of cadres influence pulmonary tuberkulosis paru patient visits. It is recommended that cadres continue to be given training and an in-depth understanding of pulmonary tuberkulosis paru, including how to treat and prevent it. Apart from that, it is also important to encourage cadres to have a positive and empathetic attitude towards pulmonary tuberkulosis paru patients, so that they can provide optimal support during patient visits.
Християнство у повоєнній Україні: виклики, тенденції, застороги. “Теологія після Бучі”
Authors: Павленко Павло
Published: October 2024

Стаття є чи не першою в українському академічному релігієзнавстві науковою розвідкою християнства в Україні доби нинішньої російсько-української війни. Автор накреслює можливі умови щодо появи в царині українського християнства після Перемоги над рашизмом нової теологічної системи, за прикладом тієї, яка започаткувалась у західному християнстві по завершенні ІІ Світової війни. Водночас у статті розкривається ряд застережень, які можуть, якщо на них не зреагувати вже сьогодні, унеможливити конструктивний розвиток зазначеного богослов'я.
Reprodução e larvicultura de lambaris em pequenas estruturas
Authors: Pereira Gabriel Andrade da Silva , Diemer Odair
Published: October 2024

O estudo teve como objetivo realizar uma revisão da literatura sobre a reprodução e larvicultura de lambaris em pequenas estruturas, com ênfase em técnicas reprodutivas, alimentação e densidade de estocagem.  A pesquisa foi de caráter exploratório conduzido por meio de seleção bibliográfica nos periódicos da CAPES e na base de dados do Google Acadêmico. Na reprodução a técnica mais empregada é a indução artificial por hipofisação com a fertilização natural em caixas de água e para avaliar a viabilidade dessa técnica foi montado uma estrutura experimental no IFMS campus Coxim, outros aspectos relevantes são: a produção média de 2.000 alevinos por fêmea, a dose de 6 mg.kg-1 extrato de hipófise de carpa proporciona bons resultados, a temperatura afeta significativamente a reprodução e os meses de novembro e dezembro são os melhores para a desova. Sobre a alimentação das larvas foi verificado uma escassez de informações, de modo geral, a utilização do Plâncton + Artemia, apresenta uma maior sobrevivência e crescimento. As larvas podem ser povoadas em uma densidade de 250 a 300 indivíduos.m-3 por 15 a 20 dias em caixas com uma sobrevivência média de 70% até a fase de alevino. Portanto, a reprodução e a larvicultura de lambaris podem ser executada com eficiência em pequenas estruturas.
Programas de assistência à mulher: uma questão fundamental para as brasileiras em suas diversas faixas etárias e sociais. Diretrizes governamentais x realidade nas diversas comunidades
Authors: Couto Magali Simone de Souza do , Iria Christopher Publio Miranda , Gonçalves Emanuelle , Leão Geovana Guimarães Garcia , Geraldo Josiele da Silva , Bernardes Lina Carla , Aguilar Michelle Gomes Valadares de , Ferreira Viviane Aparecida
Published: October 2024

O debate sobre a saúde da mulher não é algo novo no Brasil, data anterior à década de oitenta, sendo inserido na Constituição Nacional de 1988. A década de 80 foi o marco de progresso no quesito cuidado da mulher através do PAISM (MS). Porém os diversos programas ainda não significam resultados 100% positivos, tanto pelo contrário, nota-se falhas em suas aplicações.  Seja influência socioeducativa, mídia, núcleo de convívio, pela sexualização precoce, ou falta de acesso por motivos variáveis, aparecem lacunas nos programas tanto de prevenção de IST, quanto nos de Planejamento Familiar.  Um único passeio em alguma maternidade do SUS podemos visualizar a gravidade do caso ao observarmos a quantidade de jovens com menos de 18 anos que acabaram de dar à luz. A realidade, na maioria nas maternidades, é exatamente essa.Existe um ditado no Rio de Janeiro que diz que a mulher no Rio de Janeiro é mãe aos 13, avó aos 26 e bisavó ao 39. E infelizmente esse ditado não está fora da realidade. Muitos jovens deixam o Ensino Fundamental devido à maternidade precoce, porém há sempre um plano para quem está fora do plano, onde a Secretaria de Educação oferece o programa EJA, para o resgate educacional desse público.
Enhancing Learning Engagement in the Flipped Classroom using a Video-Annotation Tool
Authors: Cassano Giacomo , Di Blas Nicoletta , Mataresi Alessia
Published: October 2024

In the realm of academia, there has been a burgeoning interest in examining student engagement within the context of the flipped classroom approach, particularly at the higher education level. Nevertheless, research pertaining to a pivotal facet of this pedagogical methodology—namely, student engagement during the individualized, at-home preparatory phase—remains limited. Within this void, the primary objective of this study is to delve into the prospective benefits offered by a video annotation tool in augmenting students’ level of engagement during this autonomous study phase. Throughout the course of this investigation, a bespoke questionnaire was crafted, grounded in a multifaceted framework for evaluating student engagement, with a specific emphasis on dissecting four distinct dimensions: behavioral, emotional, agentive, and cognitive. This questionnaire is geared towards gauging student engagement within the domain of the Flipped Classroom model that relies on video-based instructional content—a facet heretofore poorly explored within the scholarly literature. Both quantitative and qualitative data were collected by administering the aforementioned questionnaire to a cohort of 68 undergraduate engineering students at Politecnico di Milano (Italy), all within the authentic context of a case study. The outcomes stemming from this empirical inquiry showcase a noteworthy enhancement in student engagement, with particular prominence accorded to the realms of emotional and agentive engagement. Moreover, this study establishes that the interactivity and proactive involvement necessitated by the video annotation tool do not obstruct students’ behavioral and cognitive engagement levels. In summation, this research endeavors to illuminate the potentiality of bridging a pivotal juncture in the Flipped Classroom paradigm, specifically the phase characterized by independent at-home study. This bridge is facilitated by the utilization of a video annotation tool designed to heighten student engagement. This transformative approach effectively transmutes the traditionally passive at-home study phase of the Flipped Classroom into an active experience, thereby enhancing the overall efficacy of this pedagogical approach.
A RETROSPECTİVE STUDY ON METHYL ALCOHOL POISONING IN TURKEY: TREATMENT STRATEGY
Authors: M. Tümer , U.B. Kaya , B. Karahalil , A.B. Erdem , C. Kavalci
Published: October 2024

Introduction: It is important to define the poison according to the symptoms of poisoning and intervene immediately. Aim of this study was to evaluate the clinical and laboratory factors in patients with methanol poisoning and explain our treatment strategy. Methods: In this study, all patients with methanol poisoning, who had presented to the emergency department of City Hospital, Ankara, Turkey. Methanol poisoning was diagnosed in all cases. Results: Our results showed that low pH, nausea and, confusion were distinguishing findings for the diagnosis of methyl alcohol poisoning in our study. Furthermore, confusion was the determinant factor between whether or not to be admitted to the intensive care unit. Based on the findings of this study, delayed admission to hospital, death and high aminotransferases were identified in methanol poisoning. Conclusion: Our treatment strategy was successful (about 80%) to save the poisoned patients.

Актуальность: важно определить яд по симптомам отравления и немедленно принять меры. Цель этого исследования состояла в том, чтобы оценить клинические и лабораторные факторы у пациентов с отравлением метанолом и объяснить нашу стратегию лечения. Методы: В этом исследовании участвовали все пациенты с отравлением метанолом, обратившиеся в отделение неотложной помощи городской больницы Анкары, Турция. Во всех случаях диагностировано отравление метанолом. Результаты: Наши результаты показали, что низкий уровень pH, тошнота и спутанность сознания были отличительными признаками для диагностики отравления метиловым спиртом в нашем исследовании. Кроме того, спутанность сознания была определяющим фактором при принятии решения о госпитализации в отделение интенсивной терапии. По результатам данного исследования при отравлении метанолом были выявлены поздняя госпитализация, летальный исход и высокие аминотрансферазы. Заключение: Наша стратегия лечения была успешной в 80% случаев спасения отравленных пациентов.

Өзектілігі: улануды улану белгілері бойынша анықтап, және дереу әрекет ету керек. Бұл зерттеудің мақсаты метанолмен уланған науқастардағы клиникалық және зертханалық факторларды бағалау және емдеу стратегиямызды түсіндіру болды. Әдістері: бұл зерттеуге Түркияның Анкара қалалық ауруханасының жедел жәрдем бөліміне жүгінген метанолмен уланған барлық науқастар қатысты. Барлық жағдайларда метанолмен улану диагнозы қойылған. Нәтижелер: біздің нәтижелеріміз төмен рН, жүрек айну және шатасу біздің зерттеуімізде метил спиртімен улануды диагностикалаудың ерекше белгілері екенін көрсетті. Сонымен қатар, шатасу реанимация бөліміне жатқызу туралы шешім қабылдауда шешуші фактор болды. Осы зерттеудің нәтижелері бойынша метанолмен улану кезінде кеш госпитализация, өлім және жоғары аминотрансферазалар анықталды. Қорытынды: біздің емдеу стратегиямыз уланған науқастарды құтқару жағдайларының 80% сәтті болды.
Issues of lexicographic bilingualism in Dagestan languages
Authors: С.Б. Юзбекова
Published: October 2024

В данной статье затрагиваются вопросы, одинаково касающиеся всех дагестанских языков в лексикографическом плане, включая самые разные виды словарей как по макролексике – одноязычные толковые, орфографические, двуязычные – переводные русско-национальные и национально-русские, диалектологические, а также оправдавшие себя на сегодняшний день словари по микролексике андалальского, хайдакского диалектов и готовящиеся по двум дагестанским языкам фитонимические словари. Нами отмечено, что на фоне лексикологии лексикография успешно и активно ушла вперед, что продиктовано ее необходимостью и востребованностью, так как словари являются немаловажным рычагом в изучении и сохранении языков.

This article addresses issues that are equally relevant to all Dagestan languages in lexicographical terms, including a variety of types of dictionaries such as monolingual (explanatory, spelling), bilingual translated Russian-national and national-Russian, dialectological, as well as dictionaries that have proven themselves to date on the microlexicon of the Andalal and Khaidak dialects and phytonymic dictionaries being prepared for two Dagestan languages. We noted that against the background of lexicology, lexicography has successfully and actively moved much forward, which is dictated by its necessity and demand, since dictionaries are an important lever in the study and preservation of languages.
Вагинальный микробиом: общие положения и взаимосвязь с гинекологическим раком
Authors: О.П. Матылевич , А.С. Гришель , С.А. Мавричев
Published: October 2024

В последние годы взаимосвязь между микробиотой и ее влиянием на здоровье человека стала предметом множества научных исследований. Хотя на сегодняшний день наиболее изучена микробиота желудочно-кишечного тракта, в последнее время интерес распространился и на другие ее виды. Нарушение качественного и количественного состава микробиоты пищеварительного тракта ведет также к изменению урогенитального микробиоценоза. Сложные взаимодействия между микробиотой кишечника и системным воспалением открывают новые аспекты в понимании развития онкологических процессов женской репродуктивной системы. Кроме того, существует тесная связь между микробиотой кишечника и уровнем циркулирующего эстрогена (эстроболомом), изменение которого может приводить к развитию некоторых видов опухолей репродуктивной системы женщин. Необходимы дальнейшие исследования, чтобы лучше понимать взаимосвязь между микробиотой и раком, что, вероятно, улучшит диагностику и лечение онкологической патологии.

In recent years, the relationship between microbiota and its impact on human health has become the subject of many scientific studies. Although the gastrointestinal microbiota has been the most studied to date, interest has recently spread to other types of microbiota. Violation of the qualitative and quantitative composition of the gastrointestinal microbiota also leads to changes in the urogenital microbiocenosis. Complex interactions between intestinal microbiota and systemic inflammation open up new aspects in understanding the development of oncological processes in the female reproductive system. In addition, there is a close relationship between intestinal microbiota and the level of circulating estrogen (estrobolome), changes in which can lead to the development of some types of tumors of the female reproductive system. Further research is needed to better understand the relationship between microbiota and cancer, which is likely to improve the diagnosis and treatment of oncological pathology.
Клинико-эпидемиологическая характеристика острых гастроэнтеритов, вызванных ротавирусами различных генотипов, у детей (обзор литературы)
Authors: М.В. Алагова , К.Д. Ермоленко
Published: October 2024

Обзор посвящен вопросам изучения современного состояния клинической картины, эпидемиологии, циркуляции генотипов ротавирусов в России и в мире. Проанализировано более 50 оригинальных статей и обзоров, в основном зарубежных, наибольшее количество статьей посвящено циркулирующим штаммам рота- вирусов, вопросам вакцинации против ротавирусной инфекции. В статье отражены современные тенденции в эпидемиологии ротавирусной инфекции (РВИ): особенности циркуляции доминирующих и редких серотипов ротавирусов в различных регионах; сезонные изменения доминирующих штаммов ротавирусов; оценка заболеваемости и возможных летальных исходов у детей от РВИ. Представлены данные о генетическом разнообразии ротавирусов и особенностях циркуляции различных генотипов в стране и в мире. Приведены сведения об эффективности вакцинации от ротавирусов в различных регионах мира, о разработке новых вакцин для профилактики ротавирусных гастроэнтеритов. Несмотря на наличие вакцин против РВИ в нашей стране, заболеваемость находится на высоком уровне, что говорит о недостаточном охвате вакцинацией, а также, возможно, о необходимости определения тех генотипов ротавирусов, которые циркулируют в нашей стране, и на основе данной информации – разработки новых вакцин.

The review is devoted to the issues of studying the current state of the clinical picture, epidemiology, circulation of rotavirus genotypes in Russia and in the world. More than 50 original articles and reviews, mostly foreign, were analyzed, the largest number of articles are devoted to circulating strains of rotaviruses, issues of vaccination against rotavirus infection. The article reflects modern trends in the epidemiology of rotavirus infection (RVI): features of the circulation of dominant and rare serotypes of rotaviruses in different regions; seasonal changes in dominant strains of rotaviruses; assessment of morbidity and possible fatal outcomes in children from RVI. Data on the genetic diversity of rotaviruses and the features of the circulation of various genotypes in country and in the world. The article provides information on the effectiveness of rotavirus vaccination in various regions of the world, on the development of new vaccines for the prevention of rotavirus gastroenteritis. Despite the availability of vaccines against RVI in our country, the incidence is high, which indicates insufficient vaccination coverage, and also, perhaps, the need to determine the genotypes of rotaviruses that circulate in our country and, based on this information, develop new vaccines.
PEOPLE'S AGGRESSIVE REACTIONS WHEN THEY BECOME FRUSTRATED BECAUSE OF VIDEO GAMES
Authors: Öze Nuran , Esengöl Görkem
Published: October 2024

Video games exist in a wide variety of formats and subcategories, and they can affect people differently. Although many researchers have focused on how players' aggression levels are affected by the video game experience, very few researchers have studied what kind of aggressive reactions are given by gamers. The People-Game- model explains how video game playing affects well-being, drawing attention to key factors such as affected player characteristics, game mechanics, and gaming experience. This study aims to identify the aggressiveness level and aggressive reaction categories, and what people do when they become frustrated because of games. To achieve this goal, qualitative methodology used to gather information. The electronic survey applied in the field research with open ended short questions. Narratives used in aggressive reaction categorization. While devices, weekly playing hours, game categories, competition, and violence levels were asked with closed-ended questions, the type of aggressive reactions was asked with one open-ended short question. 49% of the 136 people who participated in the research declared that they reacted aggressively while playing video games. It was determined that these reactions were most intense in the categories of verbal, followed by physical, third by anger and finally hostility.