bluuebunny/crossref_metadata_2025 huggingface dataset:
Rotational X‐ray coronary angiography
Authors: Raman Subha V. , Morford Ronald , Neff Matthew , Attar Talal T. , Kukielka Gilbert , Magorien Raymond D. , Bush Charles A.
Published: September 2004

We designed and implemented a digital flat‐panel‐based rotational X‐ray coronary angiography technique hypothesizing that luminal disease could be identified with less radiation exposure and contrast usage compared to conventional angiography. Individuals scheduled for diagnostic coronary angiography were prospectively enrolled. In addition to conventional acquisitions in standard planes, subjects underwent one additional left coronary artery (LCA) or right coronary artery (RCA) rotational (spin) acquisition using a predefined trajectory. Radiation exposure and contrast volume were recorded for each run. Seventy‐five subjects were enrolled. When compared with standard five‐view cine acquisition, LCA spin angiography with one cranial and one caudal run resulted in 34.38% ± 13.65% less radiation, 18.98% ± 4.97% less contrast, and comparable assessment of stenosis severity. One spin acquisition compared with three standard cine acquisitions for RCA angiography resulted in 59.31% ± 29.07% lower radiation, no significant change in contrast, and comparable assessment of stenosis severity. Rotational X‐ray coronary angiography provides comparable visualization of coronary anatomy compared with traditional nonrotational coronary angiography with significantly less radiation exposure and contrast volume. Catheter Cardiovasc Interv 2004;63:201–207. © 2004 Wiley‐Liss, Inc.
Treatment of slow/no‐reflow phenomenon with intracoronary nitroprusside injection in primary coronary intervention for acute myocardial infarction
Authors: Wang Huang‐Joe , Lo Ping‐Hang , Lin Jen‐Jyh , Lee Han , Hung Jui‐Sung
Published: September 2004

Slow/no‐reflow phenomenon is a serious problem complicating primary percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI) and is associated with a poor prognosis. From January 2002 to November 2002, 11 of the 70 consecutive patients with ST elevation AMI who were subjected to primary PCI using balloon angioplasty and/or stenting developed slow/no‐reflow phenomenon (TIMI 1 flow in 2, TIMI 2 in 8, and TIMI 2.5 in 1). They were 10 men and 1 woman, aged 64 ± 11 years (range, 46–81). The culprit vessels were six in the left anterior descending coronary artery, three in the right coronary artery, one in the left circumflex coronary artery, and one in saphenous vein graft. Multiple bolus doses (100 μg) of nitroprusside were injected into the index artery through the guiding catheter using a 3 ml syringe until the TIMI flow grade improved by at least one grade or the systolic pressure decline below 80 mm Hg (one patient). The total drug dose varied from 100 to 700 μg. Following the drug treatment, angiographic TIMI flow grade improved by at least one grade in 9 (82%) of the 11 patients (P = 0.007). The TIMI frame counts significantly decreased from 36 ± 17 frame counts to 16 ± 11 frame counts (P = 0.012). All patients were discharged without major adverse cardiovascular events. Intracoronary bolus injection of nitroprusside using a 3 ml syringe appears to be a feasible, safe, and effective technique for the management of slow/no‐reflow phenomenon complicating primary PCI. Catheter Cardiovasc Interv 2004;63:171–176. © 2004 Wiley‐Liss, Inc.
Critical stenosis of aortic and mitral valves after mediastinal irradiation
Authors: Adabag A. Selcuk , Dykoski Richard , Ward Herbert , Anand Inder S.
Published: September 2004

Radiotherapy is used widely in cancer treatment. Mediastinal irradiation is associated with valvular regurgitation; however, stenosis is rare. We present a patient with critical aortic and mitral valve stenosis after mediastinal irradiation and discuss the natural history, treatment, and prognosis of radiation‐associated valvular heart disease. Catheter Cardiovasc Interv 2004;63:247–250. © 2004 Wiley‐Liss, Inc.
Percutaneous coronary intervention or bypass surgery in multivessel disease? A tailored approach based on coronary pressure measurement
Authors: Botman Kees‐Joost , Pijls Nico H.J. , Bech Jan Willem , Aarnoudse Wilbert , Peels Kathinka , van Straten Bart , Penn Olaf , Michels H. Rolf , Bonnier Hans , Koolen Jacques J.
Published: September 2004

The optimal revascularization strategy, percutaneous coronary intervention (PCI) or coronary artery bypass graft surgery (CABG), for patients with multivessel coronary artery disease (MVD) remains controversial. The aim of the present study was to compare the long‐term outcomes after selective PCI of only hemodynamically significant lesions (fractional flow reserve, or FFR < 0.75) to CABG of all stenoses in patients with MVD. In 150 patients with MVD referred for CABG, FFR was determined in 381 coronary arteries considered for bypass grafting. If the FFR was less than 0.75 in three vessels or in two vessels including the proximal left anterior descending (LAD) artery, CABG was performed (CABG group). If only one or two vessels were physiologically significant (not including the proximal LAD), PCI of those lesions was performed (PCI group). Of the 150 patients, 87 fulfilled the criteria for CABG and 63 for PCI. There were no significant differences in the angiographic or other baseline characteristics between the two groups. At 2‐year follow‐up, no differences were seen in adverse events, including repeat revascularization (event‐free survival 74% in the CABG group and 72% in the PCI group). A similar number of patients were free from angina (84% in the CABG group and 82% in the PCI group). Importantly, the results in both groups were as good as the surgical groups in previous studies comparing PCI and CABG in MVD. In patients with multivessel disease, PCI in those with one or two hemodynamically significant lesions as identified by an FFR < 0.75 yields a similar favorable outcome as CABG in those with three or more culprit lesions despite a similar angiographic extent of disease. Catheter Cardiovasc Interv 2004;63:184–191. © 2004 Wiley‐Liss, Inc.
Alcohol septal ablation for hypertrophic obstructive cardiomyopathy: Lower alcohol dose reduces size of infarction and has comparable hemodynamic and clinical outcome
Authors: Veselka Josef , Procházková Šárka , Duchoňová Radka , Bolomová‐Homolová Ingrid , Páleníčková Jana , Tesař David , Červinka Pavel , Honěk Tomáš
Published: September 2004

Patients with highly symptomatic hypertrophic obstructive cardiomyopathy (HOCM) are considered to be good candidates for percutaneous transluminal septal myocardial ablation (PTSMA). However, there is ongoing discussion regarding the optimal dose of alcohol injected into target septal artery and the impact of infarct sizes on the clinical and hemodynamic outcome. Thirty‐four patients with symptomatic HOCM receiving maximum medical therapy were consecutively enrolled. Patients were randomized in a 1:1 ratio into one of the two arms according to dose of injected alcohol during echocardiography‐guided PTSMA procedure. Clinical, electrocardiographic, and echocardiographic evaluation were performed 6 months after the procedure in all the patients. Both groups of patients matched in all clinical and echocardiographic data. The dose of alcohol injected was 1.6 ± 0.4 and 3.4 ± 0.9 (P < 0.001) with subsequent peak of CK‐MB 1.9 and 3.2 μkat/L (P < 0.05) in group A and B, respectively. There was a correlation between amount of injected alcohol and the peak of CK‐MB (r = 0.58; P < 0.01), whereas no significant relationship (r = 0.16; P = NS) was documented between the peak of CK‐MB and left ventricular outflow gradient at follow‐up. At 6‐month follow‐up, both groups of patients were not significantly different with regard to symptoms or electrocardiographic and echocardiographic findings. In conclusion, this study suggests that the low dose (1– 2 ml) of alcohol injected into target septal branch reduces size of necrosis. Moreover, the low dose is probably as safe and efficacious as usually used doses (2–4 ml). Catheter Cardiovasc Interv 2004;63:231–235. © 2004 Wiley‐Liss, Inc.
Crystal Structure Revision and Identification of Li+‐Ion Migration Pathways in the Garnet‐Like Li5La3M2O12 (M: Nb, Ta) Oxides.
Authors: Thangadurai Venkataraman , Adams Stefan , Weppner Werner
Published: September 2004

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Charge Order and Tilt Modulation in Multiferroic KxMIIxMIII1‐x F3 (0.4 < x < 0.6) Transition Metal Fluorides with Tetragonal Tungsten Bronze Structure.
Authors: Fabbrici Simone , Montanari Erica , Righi Lara , Calestani Gianluca , Migliori Andrea
Published: September 2004

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New Compounds from Tellurocyanide Rhenium Cluster Anions and 3d‐Transition Metal Cations Coordinated with Ethylenediamine.
Authors: Brylev Konstantin A. , Mironov Yuri V. , Naumov Nikolai G. , Fedorov Vladimir E. , Ibers James A.
Published: September 2004

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Synthesis, Structure, and Bonding of BaAuTl3 and BaAuIn3: Stabilization of BaAl4‐Type Examples of the Heavier Triels Through Gold Substitution.
Authors: Liu Shengfeng , Corbett John D.
Published: September 2004

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The Solid Solution TmNi1‐x‐yIn1+x.
Authors: Lukachuk Mar'yana , Kalychak Yaroslav M. , Poettgen Rainer
Published: September 2004

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The Hexagonal Laves Phase MgIr2.
Authors: Hlukhyy Viktor , Poettgen Rainer
Published: September 2004

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Nitrogen Diffusion in Nitrogen‐Doped Yttria Stabilized Zirconia.
Authors: Kilo Martin , Taylor Marcela A. , Argirusis Christos , Borchardt Guenter , Lerch Martin , Kaitasov Odile , Lesage Bernard
Published: September 2004

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Electrochemical Performance of LaNi5‐xSnx Alloys.
Authors: Deng Haixia , Zhuang Yinghong , Liu Jingqi , Guo Jin , Lue Junxia , Yan Jialin
Published: September 2004

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Porous ZnAl2O4 Synthesized by a Modified Citrate Technique.
Authors: Chen Limiao , Sun Xiaoming , Liu Younian , Zhou Kebin , Li Yadong
Published: September 2004

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Oxotellurates(IV) of Lanthanides. Part 1. The Isotopic Series Ln2Te4O11 (Ln: La—Nd, Sm—Yb).
Authors: Meier Steffen F. , Schleid Thomas
Published: September 2004

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Synthesis and Thermal Stability of Nanocrystalline Chromium Disilicide.
Authors: Ma Jianhua , Gu Yunle , Shi Liang , Chen Luyang , Yang Zeheng , Qian Yitai
Published: September 2004

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The Cluster Ion [Pt12O8(SO4)12]4‐.
Authors: Pley Martin , Wickleder Mathias S.
Published: September 2004

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Enantioselective Henry Reaction Catalyzed by Optically Active Ketoiminatocobalt Complexes.
Authors: Kogami Youichi , Nakajima Takahiro , Ashizawa Tomoko , Kezuka Satoko , Ikeno Taketo , Yamada Tohru
Published: September 2004

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New Perfluoroalkyl‐Substituted Bisoxazolines as Chiral Ligands in Asymmetric Cu(II)‐Catalyzed Reactions.
Authors: Simonelli Barbara , Orlandi Simonetta , Benaglia Maurizio , Pozzi Gianluca
Published: September 2004

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Benzotriazolyl‐Mediated 1,2‐Shifts of Electron‐Rich Heterocycles.
Authors: Katritzky Alan R. , Bobrov Sergey , Khashab Niveen , Kirichenko Kostyantyn
Published: September 2004

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Ruthenium Nanoparticles Supported on Hydroxyapatite as an Efficient and Recyclable Catalyst for cis‐Dihydroxylation and Oxidative Cleavage of Alkenes.
Authors: Ho Chi‐Ming , Yu Wing‐Yiu , Che Chi‐Ming
Published: September 2004

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Reduction of Carbonyl Compounds with NaBH4 under Ultrasound Irradiation and Aprotic Condition.
Authors: Zeynizadeh Behzad , Yahyaei Saiedeh
Published: September 2004

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Organic Reactions in Ionic Liquids: An Efficient Method for Selective S‐Alkylation of 2‐Mercaptobenzothia(xa)zole with Alkyl Halides.
Authors: Hu Yi , Chen Zhen‐Chu , Le Zhang‐Gao , Zheng Qin‐Guo
Published: September 2004

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Decarboxylative Photooxygenation of Arylacetic Acids by Using Mercuric Oxide.
Authors: Habibi Mohammad H. , Farhadi Saeid
Published: September 2004

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Immediate and Efficient Oxidative Deprotection of Dithioacetals to Carbonyl Compounds by Zinc Dichromate Trihydrate (ZnCr2O7×3H2O).
Authors: Firouzabadi Habib , Iranpoor Nasser , Hassani Hassan , Sobhani Sara
Published: September 2004

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Highly Selective Isomerization of N‐Allylamides and N‐Allylamines.
Authors: Krompiec Stanislaw , Pigulla Mariola , Krompiec Michal , Baj Stefan , Mrowiec‐Bialon Julita , Kasperczyk Janusz
Published: September 2004

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Stereoselective Synthesis of 1,4‐Bifunctional Compounds by Regioselective Pd‐Catalyzed Allylic Substitution Reaction.
Authors: Maezaki Naoyoshi , Hirose Yuki , Tanaka Tetsuaki
Published: September 2004

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New Stereoselective Preparation of (Z)‐3‐Perfluoroalkyl‐3‐magnesiated Enoates by an Iodine—Magnesium Exchange Reaction.
Authors: Thibonnet Jerome , Duchene Alain , Parrain Jean‐Luc , Abarbri Mohamed
Published: September 2004

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Reactions of TFDA with Ketones. Synthesis of Difluoromethyl 2,2‐Difluorocyclopropyl Ethers.
Authors: Cai Xiaohong , Zhai Yian , Ghiviriga Ion , Abboud Khalil A. , Dolbier William R. Jr.
Published: September 2004

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Intramolecular Pauson—Khand Reaction of 3‐Alkynyl‐1‐alkylidenecycles: A Convenient Synthesis of [5.n.1.01,5] Tricyclic Compounds.
Authors: Ishizaki Miyuki , Masamoto Mina , Hoshino Osamu , Nishitani Kiyoshi , Hara Hiroshi
Published: September 2004

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Sonogashira Cross‐Couplings of Ynamides. Syntheses of Urethane‐ and Sulfonamide‐Terminated Conjugated Phenylacetylenic Systems.
Authors: Tracey Michael R. , Zhang Yanshi , Frederick Michael O. , Mulder Jason A. , Hsung Richard P.
Published: September 2004

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Allylation of Acetals and Ketals with Allyltrimethylsilane Catalyzed by the Mixed Lewis Acid System AlBr3/CuBr.
Authors: Jung Michael E. , Maderna Andreas
Published: September 2004

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Diastereoselective Zinc‐Catalyzed Conjugate Addition of Alkynes.
Authors: Knoepfel Thomas F. , Boyall Dean , Carreira Erick M.
Published: September 2004

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One‐Pot Synthesis of Nitriles from Aldehydes and Hydroxylamine Hydrochloride over Silica Gel, Montmorillonites K‐10, and KSF Catalysts in Dry Media under Microwave Irradiation.
Authors: Dewan Sharwan K. , Singh Ravinder , Kumar Anil
Published: September 2004

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Construction of C—S Bonds with a Quaternary Stereocenter Through a Formal Michael Reaction: Asymmetric Synthesis of Tertiary Thiols.
Authors: Palomo Claudio , Oiarbide Mikel , Dias Flavia , Lopez Rosa , Linden Anthony
Published: September 2004

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A New Precatalyst for the Suzuki Reaction — A Pyridyl‐bridged Dinuclear Palladium Complex as a Source of Mono‐ligated Palladium(0).
Authors: Beeby Andrew , Bettington Syliva , Fairlamb Ian J. S. , Goeta Andres E. , Kapdi Anant R. , Niemelae Elina H. , Thompson Amber L.
Published: September 2004

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Synthesis of Homoallylic Alcohols via Palladium‐Catalyzed Three‐Component Coupling of an Arylboronic Acid with Allenes and Aldehydes.
Authors: Hopkins Chad D. , Malinakova Helena C.
Published: September 2004

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Synthesis of Methylated Resveratrol and Analogues by Heck Reactions in Organic and Aqueous Solvents.
Authors: Botella Luis , Najera Carmen
Published: September 2004

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High Birefringent Bisdiynes and Hexatriynes Based on Double Elimination of β‐Substituted Sulfones.
Authors: Ye Fangguo , Orita Akihiro , Yaruva Jayamma , Hamada Tatsuya , Otera Junzo
Published: September 2004

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Reductive Dehalogenation of Halophenols in Sulfite—Bisulfate Medium.
Authors: Adimurthy Subbarayappa , Ramachandraiah Gadde
Published: September 2004

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A Ring Expansion Strategy in Antiviral Synthesis: A Novel Approach to TAK‐779.
Authors: Smalley Terrence L. Jr.
Published: September 2004

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A Catalytic Asymmetric Synthesis of Chiral Glycidic Acid Derivatives Through Chiral Dioxirane‐Mediated Catalytic Asymmetric Epoxidation of Cinnamic Acid Derivatives.
Authors: Imashiro Ritsuo , Seki Masahiko
Published: September 2004

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Chemistry of Polyhalogenated Nitrobutadienes. Part 1. A New Synthesis of Perfunctionalized 3‐Amino‐4‐nitrothiophenes.
Authors: Zapol'skii Viktor A. , Namyslo Jan C. , Adam Arnold E. W. , Kaufmann Dieter E.
Published: September 2004

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Synthesis and Scintillating Efficiencies of 2,5‐Diarylthiazoles with Intramolecular Hydrogen Bond.
Authors: Prezhdo Oleg V. , Lysova Irina V. , Distanov Vitalii B. , Prezhdo Victor V.
Published: September 2004

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Sulfoxide‐Directed Enantioselective Synthesis of Functionalized Dihydropyrans.
Authors: de la Pradilla Roberto Fernandez , Tortosa Mariola
Published: September 2004

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Highly Enantioselective Hetero‐Diels—Alder Reaction of Brassard Diene with Aromatic Aldehydes.
Authors: Fan Qian , Lin Lili , Liu Jie , Huang Yaozong , Feng Xiaoming , Zhang Guolin
Published: September 2004

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Synthesis and Antimicrobial Activity of New Polyfunctionally Substituted Pyridines and Their Fused Derivatives.
Authors: Elassar Abdel‐Zaher A.
Published: September 2004

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Use of Highly Reactive, Versatile and Air‐Stable Palladium—Phosphinous Acid Complex [(t‐Bu)2P(OH)]2PdCl2 (POPd) as a Catalyst for the Optimized Suzuki—Miyaura Cross‐Coupling of Less Reactive Heteroaryl Chlorides and Arylboronic Acids.
Authors: Khanapure Subhash P. , Garvey David S.
Published: September 2004

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Thienopyridine and Benzofuran Derivatives as Potent Antitumor Agents Possessing Different Structure—Activity Relationships.
Authors: Hayakawa Ichiro , Shioya Rieko , Agatsuma Toshinori , Furukawa Hidehiko , Sugano Yuichi
Published: September 2004

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The Preparation of 2‐Arylmethylidene‐8‐methyl‐8‐azabicyclo[3.2.1]octan‐3‐ones.
Authors: Zheng Guangrong , Dwoskin Linda P. , Crooks Peter A.
Published: September 2004

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An Aminomethylpyrimidine DPP‐IV Inhibitor with Improved Properties.
Authors: Peters Jens‐Uwe , et al. et al.
Published: September 2004

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The Convenient Synthesis of Hydrogen‐Bonded Ureidopyrimidinones.
Authors: Keizer Henk M. , Sijbesma Rint P. , Meijer E. W.
Published: September 2004

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3,4‐Dihydroquinazoline Derivatives as Novel Selective T‐Type Ca2+ Channel Blockers.
Authors: Lee Yong Sup , Lee Bum Hoon , Park Seong Jun , Kang Soon Bang , Rhim Hyewhon , Park Jin‐Yong , Lee Jung‐Ha , Jeong Seong‐Woo , Lee Jae Yeol
Published: September 2004

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Microwave‐Assisted One‐Pot Three Component Synthesis of Some New 4(3H)‐Quinazolinone Derivatives.
Authors: Dabiri Minoo , Salehi Peyman , Khajavi Mohammad S. , Mohammadi Ali A.
Published: September 2004

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Iodo‐Cyclization of N‐Homoallyl Thioamides Leading to 2,4‐Diaryl‐5,6‐dihydro‐4H‐1,3‐thiazines.
Authors: Murai Toshiaki , Niwa Hisayuki , Kimura Tsutomu , Shibahara Fumitoshi
Published: September 2004

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A New Synthesis of Oxcarbazepine Using a Friedel—Crafts Cyclization Strategy.
Authors: Kaufmann Daniel , Fuenfschilling Peter C. , Beutler Ulrich , Hoehn Pascale , Lohse Olivier , Zaugg Werner
Published: September 2004

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New Highly Active Taxoids from 9β‐Dihydrobaccatin‐9,10‐acetals. Part 5
Authors: Takeda Yasuyuki , Uoto Kouichi , Iwahana Michio , Jimbo Takeshi , Nagata Motoko , Atsumi Ryo , Ono Chiho , Tanaka Noriko , Terasawa Hirofumi , Soga Tsunehiko
Published: September 2004

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Ceric Ammonium Nitrate (CAN) Catalyzed Baeyer—Villiger Oxidation of Carbonyl Compounds, Specially 20‐Oxosteroids.
Authors: Goswami Papori , Hazarika Saroj , Das Archana M. , Chowdhury Pritish
Published: September 2004

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Total Synthesis of (‐)‐Dysibetaine via a Nitrenium Ion Cyclization—Dienone Cleavage Strategy.
Authors: Wardrop Duncan J. , Burge Matthew S.
Published: September 2004

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Synthesis of Na‐Protected Peptide Acids by the N→C Chain Extension Employing O,N‐bis‐Trimethylsilyl‐amino Acids Using the Mixed Anhydride Method.
Authors: Tantry Subramanyam J. , Babu Vommina V. Suresh
Published: September 2004

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A Mild, Efficient and α‐Selective Glycosidation by Using Potassium Dodecatungstocobaltate Trihydrate as Catalyst.
Authors: Rafiee Ezzat , Tangestaninejad Shahram , Habibi Mohammad H. , Mirkhani Valiollah
Published: September 2004

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Synthesis of α,ω‐Diazidoalditol Derivatives via Both bis‐ and tris‐Cyclic Sulfites and Peracetylated α,ω‐Dibromoalditols as Bielectrophilic Intermediates.
Authors: Glacon Virginie , Benazza Mohammed , El Anzi Aniss , Beaupere Daniel , Demailly Gilles
Published: September 2004

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Stereoselective Conjugate Addition of Benzyl Phenylsulfonyl Carbanions to Enoates Derived from D‐Mannitol.
Authors: Ferreira Andre R. G. , de A. Vilela Guilherme V. M. , Amorim Mauro B. , Perry Katia P. , da Silva Antonio J. R. , Dias Ayres G. , Costa Paulo R. R.
Published: September 2004

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A New General Access to Either Type of Securinega Alkaloids: Synthesis of Securinine (II) and (‐)‐Allonorsecurinine (XII).
Authors: Alibes Ramon , Ballbe Marta , Busque Felix , de March Pedro , Elias Laia , Figueredo Marta , Font Josep
Published: September 2004

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A New Approach to the Synthesis of Optically Active Alkylated Adenine Derivatives.
Authors: Zakirova N. F. , Shipitsyn A. V. , Belanov E. F. , Jasko M. V.
Published: September 2004

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Design, Efficient Synthesis, and anti‐HIV Activity of 4′‐C‐Cyano‐ and 4′‐C‐Ethynyl‐2′‐deoxy Purine Nucleosides.
Authors: Hayakawa Hiroyuki , et al. et al.
Published: September 2004

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Chemoenzymatic Syntheses of Homo‐ and Heterodimers of AZT and d4T, and Evaluation of Their anti‐HIV Activity.
Authors: Taourirte M. , Mohamed L. Ait , Rochdi A. , Vasseur J.‐J. , Fernandez S. , Ferrero M. , Gotor V. , Pannecouque C. , De Clercq E. , Lazrek H. B.
Published: September 2004

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Synthesis of 8‐Aza‐3‐deazaisoguanosine by a Novel Ring Closure of Dinitriles by Sodium Alkoxides.
Authors: Jeselnik Marjan , Jaksa Suzana , Kobe Joze
Published: September 2004

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In vitro SAR of (5‐(2H)‐Isoxazolonyl) Ureas, Potent Inhibitors of Hormone‐Sensitive Lipase.
Authors: Lowe Derek B. , et al. et al.
Published: September 2004

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II‐VI and IV‐VI Diluted Magnetic Semiconductors — New Bulk Materials and Low‐Dimensional Quantum Structures
Authors: Dobrowolski Witold , Kossut Jacek , Story Tomasz
Published: September 2004

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Magnetic Resonant Excitations in High‐Tc Superconductors
Authors: Sidis Y. , Pailhes S. , Keimer B. , Bourges P. , Ulrich C. , Regnault L. P.
Published: September 2004

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Spin Glasses. Still Complex After All These Years?
Authors: Stein Daniel L.
Published: September 2004

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Magnetic Nanostructures from Clusters
Authors: Perez A. , Dupuis V. , Tuaillon‐Combes J. , Bardotti L. , Prevel B. , Melinon P. , Jamet M. , Wernsdorfer W. , Barbara B.
Published: September 2004

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Ab Initio Investigations in Magnetic Oxides
Authors: Matar Samir F.
Published: September 2004

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Synthesis and Lithographic Applications of Highly Metalized Cluster‐Based Polyferrocenylsilanes
Authors: Chan Wing Yan , Cheng Alison Y. , Clendenning Scott B. , Manners Ian
Published: September 2004

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Organometallic Complexes of Zinc
Authors: Knochel P.
Published: September 2004

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Organometallic Complexes of Cadmium
Authors: O'Brien P. , Malik M. A.
Published: September 2004

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Copper‐Catalyzed Enantioselective Allylic Alkylation Ring‐Opening Reactions of Small‐Ring Heterocycles with Hard Alkyl Metals.
Authors: Pineschi Mauro
Published: September 2004

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Combination of Microwave Reactions with Fluorous Separations in the Palladium‐Catalyzed Synthesis of Aryl Sulfides
Authors: Zhang Wei , Lu Yimin , Chen Christine Hiu‐Tung
Published: September 2004

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Hydrocarbon C—H Bond Activation by Rhodium Porphyrins
Authors: Cui Weihong , Wayland Bradford B.
Published: September 2004

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The Chemistry and Biology of Rhazinilam and Analogues
Authors: Baudoin Olivier , Guenard Daniel , Gueritte Francoise
Published: September 2004

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Recent Developments in Marine Indole Alkaloid Synthesis
Authors: Nakagawa Masako , Nagata Toshiaki , Ono Koji , Uchida Hideharu , Watanabe Takeshi , Hatakeyama Keisuke , Akiba Masakatsu , Fuwa Mihoko , Arisawa Mitsuhiro , Nishida Atsushi
Published: September 2004

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Five‐Membered Ring Compounds in Organometallic Intramolecular‐Coordination Compounds
Authors: Omae Iwao
Published: September 2004

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Mixed Aggregates of Organolithium Compounds
Authors: Pratt Lawrence M.
Published: September 2004

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Hydrosilylation of Carbonyl and Imino Groups
Authors: Ohkuma Takeshi , Noyori Ryoji
Published: September 2004

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Metal Complexes as Catalysts for Carbon—Heteroatom Cross‐Coupling Reactions
Authors: Hartwig J. F.
Published: September 2004

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Ylides and Related Species
Authors: Bricklebank N.
Published: September 2004

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From 1,3‐Diphosphetane‐2,4‐diyls to Cyclic Anions and Cations
Authors: Sebastian M. , Schmidt O. , Fuchs A. , Nieger M. , Szieberth D. , Nyulaszi L. , Niecke E.
Published: September 2004

For Abstract see ChemInform Abstract in Full Text.
Remediation of Arsenic Contaminated Groundwater
Authors: Ptacek Carol J. , Blowes David W.
Published: September 2004

For Abstract see ChemInform Abstract in Full Text.
Solid State NMR Spectroscopy
Authors: Mann B. E.
Published: September 2004

For Abstract see ChemInform Abstract in Full Text.
Effects on instruments of the World Health Organization–recommended protocols for decontamination after possible exposure to transmissible spongiform encephalopathy–contaminated tissue
Authors: Brown Stanley A. , Merritt Katharine , Woods Terry O. , Busick Deanna N.
Published: September 2004

It has been recommended by the World Health Organization (WHO) and Centers for Disease Control and Prevention (CDC) that rigorous decontamination protocols be used on surgical instruments that have been exposed to tissue possibly contaminated with Creutzfeldt–Jakob disease (CJD). This study was designed to examine the effects of these protocols on various types of surgical instruments. The most important conclusions are: (1) autoclaving in 1N NaOH will cause darkening of some instruments; (2) soaking in 1N NaOH at room temperature damages carbon steel but not stainless steel or titanium; (3) soaking in chlorine bleach will badly corrode gold‐plated instruments and will damage some, but not all, stainless‐steel instruments, especially welded and soldered joints. Damage became apparent after the first exposure and therefore long tests are not necessary to establish which instruments will be damaged. © 2004 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 72B: 186–190, 2005
Poly(lactic‐co‐glycolic acid) microspheres as a potential bulking agent for urological injection therapy: Preliminary results
Authors: Cho Eui Ri , Kang Sun‐Woong , Kim Byung‐Soo
Published: September 2004

Injection of bulking substances has been introduced as a new therapy to treat urinary incontinence and vesicoureteral reflux. Currently available bulking substances for the injection therapies include liquid or particulated silicone, collagen gel, and polytetrafluoroethylene paste. However, these materials have shown shortcomings such as inflammation, rapid volume decrease, and particle migration to distant organs. In the present study, we evaluated poly(lactic‐co‐glycolic acid) (PLGA) microspheres as a potential injectable bulking agent for the injection therapies. PLGA microspheres (52 μm in average diameter) were injectable through various gauges of needles, as the injected microspheres showed no tendency to obstruct the needles and microsphere size exclusion was not observed upon injection through the needles. After injection of PLGA microspheres into the subcutaneous dorsum of mice, inflammation, new tissue volume change, and microsphere migration were examined. Host cells from the surrounding tissues migrated to the implanted microspheres and formed new hybrid tissue structures. The volume of the newly generated tissues was maintained approximately constant for 7 weeks. Histological analyses showed no evidence of migration of the implanted microspheres to the distant organs. In summary, PLGA microspheres were injectable and able to induce a new hybrid tissue formation without initial volume decrease or particle migration. These preliminary results suggest that this material may be a potentially useful bulking agent for urological injection therapies. © 2004 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 72B: 166–172, 2005
Does endotoxin contribute to aseptic loosening of orthopedic implants?
Authors: Greenfield Edward M. , Bi Yanming , Ragab Ashraf A. , Goldberg Victor M. , Nalepka Jennifer L. , Seabold Joscelyn M.
Published: September 2004

Aseptic loosening of orthopedic implants caused by wear particles is a major clinical problem. This review examines the hypothesis that bacterial endotoxin contributes to aseptic loosening. Clinical findings support this hypothesis: bacterial biofilms exist on many implants from patients with aseptic loosening and antibiotics in bone cement reduce the rate of aseptic loosening. Three approaches were used to demonstrate that adherent endotoxin increases bioactivity of titanium particles. These experiments measured cytokine production and osteoclast differentiation in vitro and murine calvarial osteolysis in vivo. First, removal of >99.9% of the adherent endotoxin from titanium particles significantly ablates their biological activity. Second, adding lipopolysaccharide back to these “endotoxin‐free” particles restores their biological activity. Third, cells or mice that are genetically hyporesponsive to endotoxin are significantly less responsive to titanium particles than are wild‐type controls. Other investigators have confirmed and extended these results to include virtually all orthopedically relevant types of particles, including authentic titanium alloy particles retrieved from patients with loosening. Our recent studies suggest that adherent endotoxin on orthopedic implants may also inhibit initial osseointegration of the implants. Taken together, these studies suggest that bacterial endotoxin may have a significant role in induction of aseptic loosening. © 2004 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 72B: 179–185, 2005
Analysis of photopolymerization behavior of UDMA/TEGDMA resin mixture and its composite by differential scanning calorimetry
Authors: Tanimoto Yasuhiro , Hayakawa Tohru , Nemoto Kimiya
Published: September 2004

The aim of this study was to investigate the extent of polymerization (Ep) in terms of polymerization rate of UDMA/TEGDMA resin mixtures and its composite resin, by using a differential scanning calorimeter (DSC) technique employing a photopolymerization apparatus. The resin mixtures used in this study consisted of urethane dimethacrylate (UDMA) as a base monomer and triethyleneglycol dimethacrylate (TEGDMA) as a low viscosity monomer. The concentration of TEGDMA in the mixed monomer was varied to 0, 20, 40, 60, 80, and 100 mol %. Additionally, using a base monomer consisting of 60 mol % UDMA and 40 mol % TEGDMA, four kinds of composites with silica filler of 0, 20, 40, 60, and 70 wt %, were prepared in this study. The general reaction profile and Ep values were obtained from the DSC curves. Increasing the concentration of TEGDMA resulted in a decrease in the viscosity of the UDMA/TEGDMA mixture, a delay in the time to maximum polymerization rate, and an increase in the Ep values of the resin mixtures. Furthermore, Ep values decreased with increasing filler content between 0 and 60 wt % but did not decrease further between 60 and 70 wt %. © 2004 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 72B: 310–315, 2005
Egr‐1 is activated by 17β‐estradiol in MCF‐7 cells by mitogen‐activated protein kinase‐dependent phosphorylation of ELK‐1
Authors: Chen Chien‐Cheng , Lee Wan‐Ru , Safe Stephen
Published: September 2004

Early growth response‐1 (Egr‐1) is an immediate‐early gene induced by E2 in the rodent uterus and breast cancer cells. E2 induces Egr‐1 mRNA and protein levels in MCF‐7 human breast cancer cells and reporter gene activity in cells transfected with pEgr‐1A, a construct containing the −600 to +12 region of the Egr‐1 promoter linked to the firefly luciferase gene. Deletion analysis of the Egr‐1 promoter identified a minimal E2‐responsive region of the promoter that contained serum response element (SRE)3 (−376 to −350) which bound Elk‐1 and serum response factor (SRF) in gel mobility shift assays. Hormone‐responsiveness of Egr‐1 in MCF‐7 cells was specifically inhibited by PD98059, a mitogen‐activated protein kinase kinase inhibitor, but not by LY294002, an inhibitor of phosphatidylinositol‐3‐kinase (PI3‐K). These results contrasted with hormone‐dependent activation of the SRE in the c‐fos promoter, which was inhibited by both PD98059 and LY294002. Differences in activation of the SREs in Egr‐1 and c‐fos were related to promoter sequence, which defines the affinities of Elk‐1 and SRF to their respective binding sites. Thus, Egr‐1, like c‐fos, is activated through non‐genomic (extranuclear) pathways of estrogen action in breast cancer cells. © 2004 Wiley‐Liss, Inc.
Gene positional changes relative to the nuclear substructure during carbon tetrachloride‐induced hepatic fibrosis in rats
Authors: Maya‐Mendoza Apolinar , Hernández‐Muñoz Rolando , Gariglio Patricio , Aranda‐Anzaldo Armando
Published: September 2004

In the interphase nucleus the DNA of higher eukaryotes is organized in loops anchored to a substructure known as the nuclear matrix (NM). The topological relationship between gene sequences located in the DNA loops and the NM appears to be very important for nuclear physiology because processes such as replication, transcription, and processing of primary transcripts occur at macromolecular complexes located at discrete sites upon the NM. Mammalian hepatocytes rarely divide but preserve a proliferating capacity that is displayed in vivo after specific stimulus. We have previously shown that transient changes in the relative position of specific genes to the NM occur during the process of liver regeneration after partial ablation of the liver, but also that such changes correlate with the replicating status of the cells. Moreover, since chronic exposure to carbon tetrachloride (CCl4) leads to bouts of hepatocyte damage and regeneration, and eventually to non‐reversible liver fibrosis in the rat, we used this animal model in order to explore if genes that show differential activity in the liver change or modify their relative position to the NM during the process of liver fibrosis induction. We found that changes in the relative position of specific genes to the NM occur during the chronic administration of CCl4, but also that such changes correlate with the proliferating status of the hepatocytes that goes from quiescence to regeneration to replicative senescence along the course of CCl4‐induced liver fibrosis, indicating that specific configurations in the higher‐order DNA structure underlie the stages of progression towards liver fibrosis. © 2004 Wiley‐Liss, Inc.
Zymogen activation and characterization of a major gelatin‐cleavage activity localized to the sea urchin extraembryonic matrix
Authors: Ranganathan Lavanya , Rimsay Robert , Robinson John J.
Published: September 2004

The hyaline layer (HL) is an apically located extracellular matrix (ECM) which surrounds the sea urchin embryo from the time of fertilization until metamorphosis occurs. While gelatin‐cleavage activities were absent from freshly prepared hyaline layers, a dynamic pattern of activities developed in layers incubated at 15 or 37°C in Millipore‐filtered sea water (MFSW). Cleavage activities at 90, 55, 41, and 32 kDa were evident following incubation at either temperature. The activation pathway leading to the appearance of these species was examined to determine the minimum salt conditions required for processing and to establish precursor–product relationships. In both qualitative and quantitative assays, the purified 55 kDa gelatinase activity was inhibited by 1,10‐phenanthroline (a zinc‐specific chelator) and ethylenebis (oxyethylenenitrilo) tetraacetic acid (EGTA). Calcium reconstituted the activity of the EGTA‐inhibited enzyme with an apparent dissociation constant (calcium) of 1.2 mM. Developmental substrate gel analysis was performed using various stage embryos. The 55 and 32 kDa species comigrated with gelatin‐cleavage activities present in sea urchin embryos. Collectively, the results reported here document a zymogen activation pathway which generates a 55 kDa, gelatin‐cleaving activity within the extraembryonic HL. This species displayed characteristics of the matrix metalloproteinase class of ECM modifying enzymes. © 2004 Wiley‐Liss, Inc.
Transcriptional activities of mutant p53: When mutations are more than a loss
Authors: Kim Ella , Deppert Wolfgang
Published: September 2004

The dominant oncogenic properties of mutant p53 have been recognized as a phenomenon associated with tumor progression a long time ago, even before it was realized that the major function of wild type p53 is that of a tumor suppressor. Recent advances in this fascinating area in tumor cell biology reveal that the community of mutant p53 proteins is comprised of proteins that are extremely diverse both structurally and functionally, and elicit a multitude of cellular responses that not only are entirely distinct from those mediated by wild type p53, but also vary among different mutant p53 proteins. Aberrant regulation of transcription is one of the mechanisms underlying the ability of some mutant p53 proteins to act as oncogenic factors. Systematic analyses of the transcriptional activities of mutant p53 suggest that not the loss of transcriptional activity as such, but alterations of target DNA selectivity may be the driving force of mutant p53 specific transcription underlying the growth‐promoting effects of mutant p53. This article focuses on mechanistic aspects of mutp53 “gain‐of‐function” with the emphasis on possible mechanisms underlying transcriptional activation by mutp53. © 2004 Wiley‐Liss, Inc.
Osmoregulatory action of 17β‐estradiol in the gilthead sea bream Sparus auratus
Authors: Guzmán José María , Sangiao‐Alvarellos Susana , Laiz‐Carrión Raúl , Míguez Jesús M. , Martín Del Río María Del Pilar , Soengas José Luis , Mancera Juan Miguel
Published: September 2004

The osmoregulatory action of 17β‐estradiol (E2) was examined in the euryhaline teleost Sparus auratas. In a first set of experiments, fish were injected once with vegetable oil containing E2 (1, 2 and 5 µg/g body weight), transferred 12h after injection from sea water (SW, 38 ppt salinity) to hypersaline water (HSW, 55 ppt) or to brackish water (BW, 5 ppt salinity) and sampled 12h later (i.e. 24 h post‐injection). In a second experiment, fish were injected intraperitoneally with coconut oil alone or containing E2 (10 µg/g body weight) and sampled after 5 days. In the same experiment, after 5 days of treatment, fish of each group were transferred to HSW, BW and SW and sampled 4 days later (9 days post‐implant). Gill Na+,K+‐ATPase activity, plasma E2 levels, plasma osmolality, and plasma levels of ions (sodium and calcium), glucose, lactate, protein, triglyceride, and hepatosomatic index were examined. Transfer from SW to HSW produced no significant effects on any parameters assessed. E2 treatment did not affect any parameter. Transfer from SW to BW resulted in a significant decrease in plasma osmolality and plasma sodium but did not affect gill Na+,K+‐ATPase activity. A single dose of E2 attenuated the decrease in these parameters after transfer from SW to BW, but was without effect on gill Na+,K+‐ATPase activity. An implant of E2 (10 µg/g body weight) for 5 days significantly increased plasma calcium, hepatosomatic index, plasma metabolic parameters, and gill Na+,K+‐ATPase activity. In coconut oil‐implanted (sham) fish, transfer from SW to HSW or BW during 4 days significantly elevated gill Na+,K+‐ATPase. Gill Na+,K+‐ATPase activity remained unaltered after transfer of E2‐treated fish to HSW or BW. However, in E2‐treated fish transferred from SW to SW (9 days in SW after E2‐implant), gill Na+,K+‐ATPase activity decreased with respect to HSW‐ or BW‐transferred fish. Shams transferred to HSW showed increased levels of lactate, protein, and trygliceride in plasma, while those transferred to BW only displayed increased trygliceride levels. E2‐treated fish transferred to HSW showed higher protein levels without any change in other plasmatic parameters, while those transferred to BW displayed elevated plasma glucose levels but decreased osmolality and protein levels. These results substantiate a chronic stimulatory action of E2 on gill Na+,K+‐ATPase activity in the euryhaline teleost Sparus auratas. J. Exp. Zool. 301A:828–836, 2004. © 2004 Wiley‐Liss, Inc.
Cross communication between signaling pathways: Juvenoid hormones modulate ecdysteroid activity in a crustacean
Authors: Mu Xueyan , Leblanc Gerald A.
Published: September 2004

Methyl farnesoate is a juvenoid hormone that regulates a variety of processes in crustaceans including male sex determination among daphnids (Branchiopoda, Cladocera). The synthetic juvenoids pyriproxyfen and fenoxycarb mimic the action of methyl farnesoate in daphnids. In the present study we tested the hypothesis that juvenoids also can regulate ecdysteroid activity in a crustacean (Daphnia magna). Methyl farnesoate, pyriproxyfen, and fenoxycarb all disrupted ecdysteroid‐regulated aspects of embryo development in daphnids. Exposure of ecdysteroid‐responsive cells to 20‐hydroxyecdysone reduced cell proliferation and increased mRNA levels of the ecdysone receptor and its partner protein ultraspiracle. Co‐treatment of cells with the juvenoid pyriproxyfen attenuated all of these ecdysteroid mediated responses. While juvenoids functioned as anti‐ecdysteroids in both intact embryos and in cultured cells, 20‐hydroxyecdysone showed no evidence of acting as an anti‐juvenoid. The combined effects of pyroproxyfen with the ecdysteroid synthesis inhibitor fenarimol and the ecdysteroid receptor antagonist testosterone were evaluated in an effort to discern whether the action of the juvenoids were additive with those of know anti‐ecdysteroids. The anti‐ecdysteroid effects of pyriproxyfen were non‐additive with those of either anti‐ecdysteroid. Rather, joint effects conformed to a model of synergy. These results demonstrated that juvenoids elicit anti‐ecdysteroidal activity in a crustacean through a unique mechanism of action. A model involving receptor partner deprivation is proposed that explains the synergistic interactions observed. J. Exp. Zool. 301A:793–801, 2004. © 2004 Wiley‐Liss, Inc.
Perception and possible utilization of moonlight intensity for reproductive activities in a lunar‐synchronized spawner, the golden rabbitfish
Authors: Takemura Akihiro , Susilo Endang Sri , Rahman M.D. Saydur , Morita Masaya
Published: September 2004

Rabbitfishes are known to spawn synchronously around the species‐specific lunar phase. It is considered that they perceive and utilize cues from the moon in order to be synchronized gonadal development and spawning with the lunar cycle. Using the golden rabbitfish, Siganus guttatus, which spawns synchronously around the first quarter moon during the reproductive season, we measured the fluctuation of melatonin levels and examined the response of the fish to moonlight intensity. Daily fluctuation of melatonin concentration in the blood of golden rabbitfish showed low levels during daytime and high levels during night‐time, suggesting that melatonin functions in the perception and utilization of photoperiod. Plasma melatonin concentration at the new moon was higher than that at the full moon. When the fish were exposed to moonlight at midnight of the both moon phases, the melatonin concentrations decreased to the control levels. These results show that the fish possibly perceive moonlight intensity and plasma melatonin fluctuates according to ‘lightness’ at a point of night. At the first spawning period (experiment was started one month before the spawning), the fish reared under natural conditions spawned at the expected spawning dates, whereas the fish reared under the constant darkness and lightness of night did not spawn. At the second spawning period (experiment was started 2 weeks before the spawning), the fish reared under the conditions of natural and constant darkness of night spawned but not that of constant lightness of night. It is possible that night conditions are related to synchronous gonadal development and spawning in the golden rabbitfish. J. Exp. Zool. 301A:844–851, 2004. © 2004 Wiley‐Liss, Inc.