bluuebunny/crossref_metadata_2025 huggingface dataset:
Effectiveness of Aerobic Exercise Intervention on Cardiovascular Disease Risk in Female Breast Cancer: A Systematic Review with Meta-analyses
Authors: Jiao Qian , Xu Bowen , Meng Chao , Xu Fan , Li Shanshan , Zhong Jiayi , Yang Min , Li Jiang , Li Haixia
Published: August 2023

Background
Cardiovascular disease (CVD) has become the leading cause of competitive mortality in female breast cancer (BC). Regular aerobic exercise (AE) has been widely accepted as an effective intervention to reduce cardiovascular risk in a variety of different clinical conditions. This study is aimed at evaluating the efficacy and safety of AE on cardiovascular risk factors in female BC and assessing the quality of the synthesized evidence.
Methods
We searched five English databases (Cochrane Library, PubMed, Embase, Scopus, and Web of Science) from inception to January 2023. Randomized controlled trials (RCTs) and cohort trials studying the effects of AE were included. We used Stata 16 for data synthesis, Risk of Bias 2, and the Newcastle-Ottawa Scale for methodological quality evaluation and assessed the certainty of the synthesized evidence in the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach.
Results
Forty RCTs and 6 cohort trials involving 59,050 BC patients showed AE reduced the incidence of CVD events by 29.4% [RR = 0.706, 95% CI (0.659, 0.757), low certainty] and coronary artery disease events by 36% (risk ratio [RR]: 0.64, 95% confidence interval [CI] [0.561, 0.729]; risk difference [RD] = 23.2%, 95% CI [17.6%, 29.6%], low certainty]. AE improved LVEF, and reduced weight and hip circumference. The subgroup analysis results showed that nonlinear AE increased VO2max by 5.354 ml·kg·min− 1 [MD 5.354, 95% CI (2.645, 8.062), very low certainty] and reduced fat mass by 4.256 kg [MD 4.256, 95% CI (-3.839, -0.094), very low certainty]. While linear AE reduced low-density lipoprotein cholesterol (LDL-C) by 8.534 mg/dL [MD -8.534, 95% CI (-15.511, -1.557), low certainty]. The sensitivity analysis results showed that each trial did not affect the impact index of the highly heterogeneous outcomes.
Conclusions
Our study indicates that AE has a positive effect in reducing cardiovascular risk factors. The principles of AE especially nonlinear design deserve more attention in the future. This will provide new ideas to reduce CVD events and improve the quality of life in female BC patients. However, further research on AE in female BC should take into account long-term and well-designed administration to draw definitive conclusions.
Analyzing the Salivary Levels of Cathepsin B in Oral Submucous Fibosis and Oral Squamous Cell Carcinoma for Early Detection
Authors: Ahmed Shaheen , Shabbir Alveena , Shaikh Abdul , Jamil Soofia , Shaikh Sabhita , Farooqui Waqas
Published: August 2023

Background:
Oral squamous cell carcinoma is one of the most prevalent and common cancers of oral cavity with significant higher rates of mortality and morbidity. Many of the OSCC are known to be preceded by oral potentially malignant disorders such as Oral Submucous Fibrosis. OSF is a chronic and insidious condition with a high malignant transformation potential into OSCC. Salivary biomarker analysis has been considered as a promising approach for early detection of malignant potential of OSF. Cathepsin B is a lysosomal cysteine protease. In many malignancies increased levels of Cathepsin B were observed including OSCC. The present study was designed to analyze and determine the salivary Cathepsin B levels in OSF and OSCC.
Method:
150 research participants in total were included in this study which were further divided into 3 groups, 50 in each group. Group 1 comprised 50 OSF patients, Group 2 comprised 50 OSCC patients and group 3 comprised 50 control group. Salivary Cathepsin B levels were analyzed in all 3 groups by using ELISA technique after saliva sample collection.
Results:
Cathepsin B salivary levels were found to be increased significantly in both OSF and OSCC patients in comparison to control group with significant higher < 0.001 p-value. Highest mean salivary Cathepsin B levels were found in OSF 9.50s ± 7.3, followed by OSCC 4.54 ± 5.9 and control group 0.45s ± 0.9 respectively.
Conclusion:
Cathepsin B salivary levels were observed to be increased significantly both in patients of OSF and OSCC. Therefore, Cathepsin B can be considered a useful and beneficial salivary biomarker for early detection of OSCC.
In Silico Analysis of Cloned Brown Planthopper Genes Unveiled OsJ_28113 as a Key Regulator in Triggering Resistance Response in Rice
Authors: Kaur Pavneet , Pankaj Rana , Kumar Kishor , Kaur Ramanjot , Neelam Kumari
Published: August 2023

Brown planthopper (BPH) is a highly destructive insect pests of rice, causing significant yield loss. Due to its constantly evolving nature, continuous analysis of BPH's protein domain-interacting partners is essential. In the present study, in silico approach was followed to predict 3-D structure of cloned BPH-resistant proteins (Bph6, Bph9, Bph14, Bph17, Bph18, Bph26, Bph29 and Bph32) using a comparative modeling approach and their interaction studies. The Interactome analysis revealed a key regulator, OsJ_28113, responsible for transducing extracellular signals into intracellular responses, potentially aiding in activating proteins that provide resistance against BPH. The proposed model provides insights into the structure and active sites of these proteins, offering opportunities to develop novel strategies for BPH control in rice plants. The molecular profile analysis revealed that BPH resistance genes containing the CC-NBS-LRR domain have varying length of amino acid chains ranging from 1082 for Bph30 to the longest (2024) for Bph6. Bph26 and Bph18 demonstrated high sequence similarity containing NB-ARC and LRR domains. The secondary structure prediction results anticipated that all the proteins, except Bph30, are cytoplasmic and soluble. The in silico findings support the notion that variability in resistance genes is a result of ongoing evolutionary interactions between plants and insect pests. Additionally, the study uncovered higher ligand binding affinities towards jasmonic acid compared to salicylic acid, paving the way for further research on receptor-ligand recognition and signaling mechanisms against rice planthoppers.
Development and quality assessment of the psychometric properties of the Self-Efficacy in Lifestyle Counselling scale (SELC 20+20) using Rasch analysis
Authors: Alenius Sara , Westergren Albert , Lindström Petra Nilsson , Nilsson Marie , Rask Marie , Behm Lina
Published: August 2023

Background
Globally as well as in Sweden, diseases that are caused by unhealthy lifestyle habits are the most common causes of death and disability. Despite guidelines that obligate all health care professionals to counsel patients about lifestyle, studies have shown that this is not prioritized within health care. One reason for this omission, among nurses, is a lack of confidence in knowledge and counselling skills. This study aimed to develop and provide a quality assessment of the psychometric properties of an instrument to measure self-efficacy in lifestyle counselling.
Methods
A measurement instrument, inspired by an existing American instrument following Bandura’s recommendations for the development of self-efficacy measures, was developed according to Swedish national guidelines for disease prevention. The instrument was revised after 18 kognitive interviews with nurses, student nurses and clinical experts and was administered to 310 nursing students at different education levels. The instrument was tested with Rasch model analysis with a focus on dimensionality, local dependency, targeting, reliability, response category functioning, Rasch model fit, and differential item functioning by age, gender, educational level and previous health care education.
Results
The development of the instrument resulted in 20 + 20 items, 20 about self-efficacy in knowledge and 20 about self-efficacy in the ability to counsel persons about their lifestyle. The analyses showed that knowledge and ability are two different, but related constructs and that ability is more demanding than knowledge. The findings indicate (considering dimensionality and local dependency) that all 20 items within the knowledge construct as well as the 20 items within the ability construct can be summed to obtain two separate but related total scores, where knowledge (reliability 0.91) is a prerequisite for ability (reliability 0.93). The items represented lower self-efficacy than reported by the respondents. The response categories functioned as expected, the Rasch model fit was acceptable, and there was no differential item functioning.
Conclusions
The SELC 20 + 20 was found to be easy to understand with an acceptable respondent burden, and the instrument showed good measurement properties. The instrument can be a useful tool in the professional education of health care personnel and clinically in health care.
Rising Tides: Analytic Modeling of Tidal Effects in Binary Neutron Star Mergers
Authors: O'Dell Alexander , Hamilton Maria C. Babiuc
Published: August 2023

The gravitational waves produced by binary neutron star mergers offer a unique window into matter behavior under extreme conditions.In this context, we model analytically the effect of matter on the gravitational waves from binary neutron star mergers. We start with a binary black hole system, leveraging the post-Newtonian formalism for the inspiral and the Backwards-one-Body model for the merger.We combine the two methods to generate a baseline waveform and we validate our results against numerical relativity simulations. Next, we integrate tidal effects in phase and amplitude to account for matter and spacetime interaction, by using the NRTidal model, and test its accuracy against numerical relativity predictions, for two equations of state, finding a mismatch around the merger. Subsequently, we lift the restriction on the coefficients to be independent of the tidal deformability, and recalibrate them using the numerical relativity predictions. We obtain better fits for phase and amplitude around the merger, and are able to extend the phase modeling beyond the merger.We implement our method in a new open-source Python code, steered by a Jupyter Notebook.Our research offers new perspectives on analytically modeling the effect of tides on the gravitational waves from binary neutron star mergers.
There exists a correlation between hemoglobin concentration and metabolic dysfunction
Authors: Zhao Linlin , Cui Man , Zhou Hui , Li Meng
Published: August 2023

Background
The prevalence of metabolic unhealthy has emerged as a significant concern within the public health domain on a global scale. The potential correlation between hemoglobin concentration and metabolic unhealthy remains uncertain. Consequently, we endeavoured to examine this relationship both at the initial assessment and during the subsequent 3-year follow-up period.
Methods
A total of 4178 participants were enrolled in a 3-year follow-up study. Each participant completed a questionnaire and underwent anthropometric measurements and laboratory tests. The association between hemoglobin levels and metabolic abnormalities was evaluated using one-way ANOVA and logistic regression models.
Results
In comparison to the metabolically healthy group, the metabolically unhealthy group exhibited elevated baseline age, SBP, DBP, BMI, ALT, ALB, SCR, UA, FBG, TC, TG, HB, and PWV, while HDL-C was decreased. These findings were statistically significant. The prevalence of abnormal metabolism progressively increased with higher baseline hemoglobin levels. At the end of the follow-up period, hemoglobin levels were significantly higher in the metabolically abnormal group than at baseline. Furthermore, there was a positive correlation between baseline hemoglobin concentration and the incidence of metabolic abnormalities.
Conclusions
Monitoring the concentration of hemoglobin serves as a cost-effective and easily accessible means of detecting the onset of metabolic illness at an early stage.
Synthesis, Anti-mycobacterial activity, Molecular Docking and ADME analysis of spiroquinoxaline-1,2,4-oxadiazoles via [3+2] cycloaddition reaction under ultrasound irradiation
Authors: Kanchrana Madhu , Krishna Gamidi Rama , Kumari Jyothi , Sri Dharmarajan , Basavoju Srinivas
Published: August 2023

A convenient ultrasound methodology was employed to attain spiroquinoxaline-1,2,4-oxadiazoles via[3+2] cycloaddition of quinoxalineSchiff bases and aryl nitrile oxides at room temperature. This approach evades standard heating and column chromatography while producing high yields and lesser reaction times. The target compounds 3a-p were well characterized and their in vitro anti-mycobacterial activity (anti-TB) was evaluated. Among the screened compounds 3i has displayed promising activity against Mycobacterium tuberculosis cell line H37Rv with MIC value 0.78 µg/mL. However, three compounds (3f, 3h and 3o) exhibited potent activity with MIC value 6.25 µg/mL. To further understand the binding interactions, the synthesized compounds were docked against the tuberculosisprotein 5OEQ using in silicomolecular docking. Moreover, the utmost active compounds were additionally partitioned for their cytotoxicity against RAW 264.7 cell line, which revealed that the compounds 3f, 3h, 3i and 3o were less harmful to humans. Furthermore, the synthesized compounds were tested for ADME qualities, and the results suggest that this series is useful to produce innovative and potent anti-tubercular medicines in the future.
Adaptability and stability of black bean genotypes with normal and early cycle
Authors: Ambrósio Moisés , Santos Raiane Mariani , Daher Rogério Figueiredo , Santana Josefa Grasiela Silva , Vidal Ana Kesia Faria , Nascimento Maxwel Rodrigues , Leite Cleudiane Lopes , Souza Alexandre Gomes , Freitasa Rafael Souza , Stida Wanessa Francesconi , Farias João Esdras Calaça
Published: August 2023

In the selection process of common bean genotypes with high yield performance associated with high adaptability and stability, accurate statistical procedures should be used, which promote greater precision in the comparison of means. In this context, the study aimed to select black bean genotypes of a normal and early cycle that simultaneously combine high yield, adaptability, and stability via non-parametric methods and mixed models. For this, two simultaneous trials were conducted in 2020 and 2021 in Campos dos Goytacazes - RJ. The first trial consisted of 14 black bean genotypes of the normal cycle; the second trial consisted of 14 black bean genotypes of the early cycle. The experimental design was a randomized block design with 14 normal-cycle and 14 early-cycle genotypes and three replications. After detecting the significant genotype-environment interaction (GxE), the adaptability and phenotypic stability of the genotypes were analyzed by the methods of the harmonic mean of the relative performance of genotypic values (HMRPGV), Annicchiarico (1992), Lin & Binns (1988), and stability index called WAASB (Weighted Average of Absolute Scores). The genotypes that gather adaptability and stability associated with high yield potential, sufficient for a recommendation for the state of Rio de Janeiro, are BRS Esteio, CNFP 19325 belonging to the normal group and BRS Campeiro, CNFP 17445, and CNFP 17466 belonging to the early group. The combined use of mixed model methodologies and non-parameter models enables a more accurate selection of the most promising genotypes.
Effect of PGPR and mixed cropping on mycorrhizal status, soil fertility, and date palm productivity under organic farming system
Authors: OU-ZINE Mohamed , SYMANCZIK Sarah , KINANY Said El , AZIZ Larbi , FAGROUD Mustapha , ABIDAR Ali , MÄDER Paul , ACHBANI El Hassan , HAGGOUD Abdellatif , HILALI Rania EL , ABDELLAOUI Mustapha , BOUAMRI Rachid
Published: August 2023

A field study was carried out for two years at an organic farm under arid climate in Morocco to investigate the effect of an integrated biofertilization approach on Arbuscular Mycorrhizal Fungal (AMF) abundance and infectivity, soil fertility, yield, and fruit quality of date palm. The biofertilization approach included three management practices namely application of compost, inoculation with a consortium of native PGPR strains originally isolated from date palms of Drâa-Tafilalet region (Pseudomonas koreensis, Serratia nematodiphila, S. marcescens, and Klebsiella sp.) and using mixed-cropping with sorghum. Accordingly, four treatments were established in this study: 1) mixed-cropping with sorghum, 2) PGPR inoculation, 3) sorghum + PGPR, and 4) control (without sorghum or PGPR). All treatments received compost as organic amendment. Results revealed that mixed-cropping with sorghum significantly increased AMF colonization intensity and spore density by more than 50% and 29%, respectively. Sorghum association also resulted in a significant increase in organic matter concentrations of up to 2.95% against 2.45% in monocropping soils. The integrated biofertilization approach resulted in the highest yield with an increase rate of 10.6% and 12.1% in the first and the second year, respectively compared to date palms receiving compost alone. Similarly, the mineral composition and quality characteristics of date fruits were significantly improved. The enhancement of soil fertility and date palm productivity under harsh environmental conditions represents a first step towards the adoption of sustainable practices in the region and in similar areas.
Bacteriophage and non-pathogenic vibrio to control diseases in black tiger shrimp (Penaeus monodon) aquaculture
Authors: Hossain Md. Mer Mosharraf , Tanni Lutfun Nahar , Rahman Md. Anisur , Farjana Nawshin , Moon Rubab Sharmeen , Tonni Nishat Zahan , Mekat Mahbuba Rahman , Mojumdar Shoumik , Prince Nimur Rahman , Rojoni Suraiya Alam , Smrity Ummay Rubayea , Sen Bipul Kumar , Saha Pobitra Kumar
Published: August 2023

The study aimed to address the recurring outbreaks of microbial diseases in black tiger shrimp (Penaeus monodon) aquaculture in Bangladesh by utilizing bacteriophages and non-pathogenic Vibrio. Bacteriophages were isolated from sewage water collected from a shrimp farm, hatchery, and the JUST campus. The infectivity of the bacteriophages against various Vibrio strains was evaluated to determine their bacteriolytic activity. Non-pathogenic Vibrio strains were obtained from suspected diseased isolates collected from the south-western region of Bangladesh through PCR testing. In laboratory tests, the bacteriophages successfully infected 91% of the tested Vibrio strains (19 out of 21 strains). In the experimental unit, shrimp treated with phage prophylaxis and phage treatment exhibited significant protection against Acute Hepatopancreatic Necrosis Disease (AHPND) and survived a deadly bacterial challenge. PCR amplification identified five non-pathogenic Vibrio strains from a total of 35 suspected diseased isolates. Field trials were conducted, applying cultured bacteriophages at a concentration of 1.5x106 PFU/ml and non-pathogenic Vibrio at 5x105 CFU/ml. These trials demonstrated improved protection against infections and did not result in severe mortality during the adaptive research phase. Morphological tests conducted on the cultured shrimp revealed a muscle gut ratio greater than 4:1 and no abnormal deformities in the appendages or overall body of the shrimp, indicating their overall health and well-being. Bacteriological tests conducted on the shrimp samples showed an 18% bacterial infection rate, primarily involving Vibrio cholerae, Vibrio parahaemolyticus, and some other bacteria. However, these infections did not result in a disease outbreak. PCR amplification conducted in the fish molecular biology lab at JUST yielded negative results for AHPND, White Spot Syndrome Virus (WSSV), and Enterocytozoon hepatopenaei (EHP). These results highlight the potential of using bacteriophages and non-pathogenic Vibrio as a sustainable approach to prevent and control microbial diseases in shrimp aquaculture. The study provides valuable insights into the development of alternative strategies to combat antibiotic resistance and support the growth of the shrimp industry in Bangladesh.
Identification of ferroptosis-related prognostic models and FDFT1 as a potential ferroptosis driver in colorectal cancer
Authors: Duan Lili , Cao Lu , Liu Jinqiang , Wang Zixiang , Liang Jie , Feng Weibo , Liu Yi , Feng Fan , Zhang Jian , Zheng Jianyong
Published: August 2023

Background: Prediction of colorectal cancer (CRC) prognosis is challenging. Ferroptosis constitutes a newly reported kind of cell death, and its association with CRC prognosis remains unexplored. Herein, we aimed to develop ferroptosis-related gene (FRG) signatures to predict overall survival (OS) along with disease-free survival (DFS) in individuals with CRC.
Methods: The clinical data and mRNA expression were extracted from the TCGA web data resource. The Lasso algorithm was utilized to construct the OS and DFS prediction signatures. Independent data from GSE38832 were used for verification.
Results: Our findings revealed there was a discrepancy in the expression of 85% of FRGs between CRC and healthy tissues. Among them, 11 prognostic genes were identified using UniCox analysis. Predicted risk scores from the two models stratified patients into low- as well as high-risk groups and were demonstrated as independent prognostic factors using MultiCox analysis. The efficacy of the models was verified using ROC curve analysis. Functional enrichment analysis indicated that cancer-linked pathways were abundant in the high-risk group, and that immune status differed between the two risk groups. The CMap web data resource helped in identifying a total of sixteen potential drugs. In addition, FDFT1 was proved to play an anti-tumor role in CRC and may promote ferroptosis by regulating the expression of ISCU.
Conclusions: Our FRG-based prognostic models are reliable predictive tools for CRC patients, suggesting that FRGs may be potential targets for CRC therapy.
Variation in water use by mammals in Khao Phaeng Ma Non-hunting Area, Thailand
Authors: Chaiyarat Rattanawat , Thongkrathok Piyamaporn , Maisuwan Wanwipa , Chantra Amornrat , Chimplee Jinda , Cheachean Navee , Assawaklang Songkrit , Youngpoy Namphung
Published: August 2023

Background Access to suitable water sources is important for mammals. This study compared species diversity and the water use by mammals among water springs, standard artificial ponds, and water pans within the Khao Phaeng Ma Non-Hunting Area in 2020 and 2021. Methods Two camera traps were installed at each water sources for 749 nights with a total of 12 water sources. A total of 19,467 photographs were recorded comprising 13,777 photographs of gaur (Bos gaurus, the vulnerable and most important in the area), and 5,690 photographs of other mammals. Results In the wet seasons of 2020 and 2021, the relative use was highest at standard artificial pond number 2 and water pan number 1. In the dry seasons of 2020 and 2021, the relative use was highest at water pan number 1 and 2. During the study period, the number of species was highest in water pan number 1 (10 species, diversity index (H´) = 1.38), and water pan number 2 (11 species,H´= 1.75). Gaur, sambar deer (Rusa unicolor), red barking deer (Muntiacus vaginalis), wild boar (Sus scrofa), and Asian black bear (Ursus thibetanus) used water pan and standard artificial pond rather than water spring. Conclusions The use of water spring was associated with water period (months), while standard artificial pond and water pans were associated with water surface area, water depth, altitude, species diversity, species richness, and number of mammals photographed. Water pans were more suitable for utilization by mammals than other water sources.
Change in macular perfusion after surgical treatment in patients with idiopathic macular hole: a retrospective cohort study
Authors: Liu Weixian , Chen Chunmei , Huang Xionggao , Wang Ling
Published: August 2023

Objective
To investigate prognostic predictive value of postoperative change in macular perfusion for idiopathic macular hole (IMH).
Methods
IMH patients who received posterior vitrectomy with internal limiting membrane peeling and gas tamponade were retrospectively included. Macular perfusion evaluated by vessel density and capillary perfusion density were collected from examination records of optical coherence tomography angiography (OCTA) performed before and after surgical treatment. Postoperative improvement in best-corrected visual acuity (BCVA) was studied as the outcome. Multivariable logistic regression was employed to investigate the association between change in macular perfusion and the outcome after adjusting for preoperative characteristics.
Results
Fifty-two eyes of 52 patients (71.2% female) were included into the analyses, with a mean age of 59.7 ± 6.6 years old and a mean basal macular hole diameter of 913.8 ± 250.4 µm. Vessel density increased from 17.3 ± 2.3 mm-1 to 18.1 ± 2.6 mm-1 one month after surgical treatment (P < 0.001), and capillary perfusion density increased from 36.8 ± 7.7% to 47.3 ± 11.1% (P < 0.001), together with an improvement in BCVA (logMAR from 1.2 ± 0.2 to 0.6 ± 0.4, P < 0.001). Results of univariable linear regress suggested poor preoperative BCVA and large macular hole size were associated with poor postoperative BCVA. After taking these variables into account, multivariable logistic regression suggested greater increase in capillary perfusion density was associated with better improvement in preoperative BCVA, but such an association was not observed in the change in vessel density.
Conclusion
Change in capillary perfusion density assessed with OCTA as a proxy for macular perfusion may be used as a prognostic predictor of IMH patients who received surgical treatment.
Renal Medullary Oxygenation during Laparoscopic vs Open Surgery: The Impact of Blood Pressure Management. A pilot randomized controlled trial
Authors: Chaba Anis , Hacking Doug , Slifirski Hugh , Cogan Rebecca , Spano Sofia , Maeda Akinori , Eastwood Glenn , Bellomo Rinaldo
Published: August 2023

Purpose
The impact of blood pressure targets and surgical approach (laparoscopic or open) on continuous urinary oxygenation (PuO2), a validated surrogate of renal medullary PO2, during general surgery, is unclear. We aimed to assess the effects of different blood pressure targets and surgical procedures on PuO2.
Methods
We randomized patients receiving either laparoscopic or open surgery into two mean arterial pressure (MAP) target groups: usual MAP or a high MAP. We measured PuO2 in real-time and analyzed it according to the type of surgery and blood pressure target. The study was retrospectively registered on the 5th of July 2023 (ACTRN12623000726651).
Results
We included 43 participants who underwent either laparoscopic (n = 20) or open surgery (n = 23). We found that PuO2 significantly decreased during both laparoscopic and open surgery under a usual blood pressure target (-51% and − 49%, respectively). However, there was a sharper fall with laparoscopic surgery resulting in a higher PuO2 with open surgery (mean difference: 11 ± 1 mmHg higher; p < 0.001). Targeting a higher MAP resulted in a higher PuO2 over time during laparoscopic surgery (mean difference: 7 ± 1 mmHg, p < 0.001). In contrast, targeting a usual MAP resulted in a higher PuO2 during open surgery (mean difference: 7 ± 1 mmHg, p < 0.001).
Conclusion
Surgical approach and intraoperative blood pressure targets significantly impact urinary oxygenation. Further studies with larger sample sizes are needed to confirm these findings and understand their potential clinical implications.
Transformation of mothers’ values through an online multidisciplinary group consultation on pregnancy and childcare: The Trajectory Equifinality Approach
Authors: Tani Haruka , Sugao Shoko , Kitabatake Yasuji , Matsuzaki Masayo , Nakamoto Goji , Endo Masayuki
Published: August 2023

In Japan, developing concrete support for mothers facing child-rearing difficulties and anxiety has become an important social issue. Moreover, with the onset of the COVID-19 pandemic, the availability of support previously received by mothers had become limited. To address this issue, an online group consultation involving multidisciplinary specialists was conducted at the Osaka University. This study aimed to examine how participants’ childcare anxiety and child-rearing difficulties experienced prior to group consultation changed after their participation, and to identify the factors that facilitated this transformation. Semi-structured interviews were conducted with group consultation participants and analyzed using the Trajectory Equifinality Approach. The findings revealed a process whereby mothers who harbored worries regained their confidence and raised their children with peace of mind, through the affirmation they received from professionals and other participants. Additionally, mothers who held values emphasizing perfection and correctness in child-rearing experienced these transformed into values that brought personal fulfilment. These findings indicate that such group consultations can function as a platform to foster peace of mind and confidence in parenting.
Atmospheric Carbon Dioxide Measurement Using 1.5-µm Double- Pulse IPDA lidar over the Desert
Authors: Fan Chuncan , Yang Juxin , Liu Jiqiao , Bu Lingbing , Wang Qin , Wei Chong , Zhang Yang , Zhu Xiaopeng , Li Shiguang , Zang Huaguo , Chen Weibiao
Published: August 2023

The Integrated Path Differential Absorption (IPDA) lidar is capable of accurately measuring regional carbon dioxide (CO2) column concentrations, which is crucial for understanding the carbon cycle in the biosphere and predicting future climate change. The space-borne IPDA lidar has become the preferred sensor for measuring global CO2 column concentrations(XCO2) on days and nights. To validate the data processing methods of space-borne lidar, an airborne IPDA lidar was designed for a flight experiment.In July 2021, the airborne experiment was implemented in Dunhuang, Gansu Province, China (39–41°N, 93–96°E), where the aircraft was equipped with a developed lidar that could measure both aerosols profiles and CO2 concentrations, a wind measurement lidar, and an in-situ greenhouse gas analyzer (GGA). To minimize measurement errors, the energy monitoring part was optimized. The differential absorption optical depth (DAOD) was calculated using the Pulse Integral Method (PIM) algorithm, and the CO2 column-averaged dry-air mixing ratio was calculated using various averaging methods. The IPDA lidar measured XCO2 over the Dunhuang validation site to be 405.572 ppm, with a long-term correlation coefficien of 91.2% with the GGA. Furthermore, the IPDA lidar and the LGR both measured changes in XCO2 concentration resulting from aircraft exhaust.
Detoxification of tequila vinasse by Trametes sanguineus: a biotechnological approach to laccase production and water reuse in seedling growth
Authors: Teymennet-Ramírez Karla , García-Morales Soledad García-Morales , Hernández-Fernández Overlin , Barrera-Martínez Iliana
Published: August 2023

Tequila vinasse, a by-product generated during agave fermentation, is a wastewater characterized by its dark color and composition, which includes water, alcohol, sugars, phenolic compounds, proteins, among others. Its high chemical oxygen demand (COD) and pH levels classify it as hazardous to the soil, plants, and aquatic organisms, requiring the development of treatment strategies or proper disposal methods. It is worth noting that vinasse contains numerous compounds that can be recovered and valorized. In this study, different concentrations of tequila vinasse (100%, 70%, and 50%) were subjected to a 10-day treatment with Trametes sanguineus. Significant reductions in color, phenolic content, and COD were observed across all conditions, with approximately 70% decolorization and 60% reduction in phenolic content achieved. Among the different conditions tested, the 50% concentration exhibited the highest laccase production, reaching approximately 1,779 U/L on the 5th day of cultivation, while laccases were also detected in the other conditions. Subsequently, the potential of the treated vinasse for germination and seedling growth was assessed. Trametes sanguineus was removed from the vinasse, and the resulting supernatant was applied directly to the seeds. Lettuce and tomato seeds were employed in these assays, both of which demonstrated seed germination rates ranging from 50–80%, respectively. Notably, vinasse without T. sanguineus treatment did not exhibit any germination. Additionally, seedling growth assays were conducted, revealing that the treated vinasse supported the growth of tomato and lettuce plants, with root-related features comparable to the control. Valorization of agroindustrial waste presents a viable approach for obtaining value-added products.
Long term survival at 6 and 12 months in venous thromboembolic disease in patients anticoagulated with rivaroxaban and warfarin: propensity score matching study
Authors: Ramos-Isaza Estefan , Tuta-Quintero Eduardo , Bastidas-Goyes Alirio , Diaz-Quijano Diana , Aponte Carolina , Angel Julian Manuel Espitia , Beltran Daniel Andrés Pinto , Rincón-Hernández Johan , Sánchez-Cuellar Juan , Pérez-Bueno Jesus , Cadavid Luis F. Giraldo
Published: August 2023

Background: Venous thromboembolic disease (VTE) is characterized by the obstruction of venous blood flow by a thrombus, whose survival data and clinical outcomes, such as disease recurrence and bleeding in patients with warfarin anticoagulant therapy compared with rivaroxaban in the Latin American population is limited.
Methods: A retrospective cohort study with propensity score matching analysis was conducted in patients with VTE anticoagulated with warfarin or rivaroxaban treated. The radiological report defined VTE with a confirmed diagnosis of pulmonary embolism and deep ve. Survival analysis was performed using a Kaplan-Meier curve for each of the intervention groups, and it was compared using a log-rank test.
Results: Of 2193 potentially eligible patients with a suspected diagnosis of VTE, 505 patients entered the analysis; of these, 285 subjects were managed with warfarin and 220 anticoagulated with rivaroxaban. Bleeding at six months occurred in 2.7% (6/220) of patients on rivaroxaban vs. 10.2% (29/258) on warfarin in the unmatched population (p=0.001) and in 2.9% (6/209) with rivaroxaban and 11.0% (23/209) with warfarin in the pairing (p=0.001). At 6 and 12 months, there was a survival of 97.1% for rivaroxaban and 97.6% for warfarin 97.6% (p=0.76), and 94.7% for rivaroxaban and 95.7% for warfarin (p=0.61), respectively.
Conclusion: Rivaroxaban, compared to warfarin in VTE management, has no impact in terms of survival at 6 and 12 months, nor a decrease in the occurrence of new thromboembolic episodes. However, it decreases the risk of bleeding at six months.
Hybridization of aluminium-silicon alloy with boron carbide and ferrotitanium and the effect on mechanical properties as auto-material
Authors: Oladosu Oluwafemi Timothy , Akinwande Abayomi Adewale , Adesina Olanrewaju , Sanyaolu Olufemi Oluseun , Obadele Babatunde Abiodun
Published: August 2023

The brittle nature of ceramic reinforcement in metal matrixes has initiated a gap in the utilization of metal-based particles as supplementary reinforcement. This present study investigated the influence of adding FeTi as supplementary reinforcement to B4C and FeTi in an aluminum-silicon (Al-12Si) matrix for automobile applications. The FeTi alloy was introduced at 3, 6, and 9 wt.% alongside the 5 wt.% B4C particles. The effect of such an addition on the morphology, physical, and mechanical properties was examined. The X-ray diffraction pattern identified the presence of B4C and FeTi reinforcing phases alongside Al3Fe and Ti5Si3 phases. The examined morphology revealed that the particles were well dispersed in the matrix, with consequent effects on their properties. Porosity was reported to reduce linearly with a rise in FeTi dosage, consequently engendering a linear rise in density and relatively high density. Inclusive of the hardness, the yield and ultimate strength were enhanced progressively upon a progressive rise in FeTi dosage, with a contrary reduction in ductility. The result revealed that the inclusion of FeTi reinforcing fillers in the matrix is capable of causing an appreciable improvement in the mechanical properties of the composite.
Intrinsic capacity trajectories and socioeconomic inequalities in health: the contributions of wealth, education, gender, and ethnicity
Authors: Salinas-Rodríguez Aaron , Fernández-Niño Julián Alfredo , Rivera-Almaraz Ana , Manrique-Espinoza Betty
Published: August 2023

Background
Life-long health inequalities exert enduring impacts and are governed by social determinants crucial for achieving healthy aging. A fundamental aspect of healthy aging, intrinsic capacity, is the primary focus of this study. Our objective is to evaluate the social inequalities connected with the trajectories of intrinsic capacity, shedding light on the impacts of socioeconomic position, gender, and ethnicity.
Methods
Our dynamic cohort study was rooted in three waves (2009, 2014, 2017) of the World Health Organization's Study on Global AGEing and Adult Health in Mexico. We incorporated a nationally representative sample comprising 2722 older Mexican adults aged 50 years and over.
Baseline measurements of socioeconomic position, gender, and ethnicity acted as the exposure variables. We evaluated intrinsic capacity across five domains: cognition, psychological, sensory, vitality, and locomotion. The Relative Index of Inequality and Slope Index of Inequality were used to quantify socioeconomic disparities.
Results
We discerned three distinct intrinsic capacity trajectories: steep decline, moderate decline, and slight increase. Significant disparities based on wealth, education level, gender, and ethnicity were observed. Older adults with higher wealth and education typically exhibited a trajectory of moderate decrease or slight increase in intrinsic capacity. In stark contrast, women and indigenous individuals were more likely to experience a steeply declining trajectory.
Conclusions
These findings underscore the pressing need to address social determinants, minimize discrimination, and confront structural racism to ensure equal access to resources and opportunities across the lifespan. It is imperative for policies and interventions to prioritize these social determinants in order to promote healthy aging and alleviate health disparities. This approach will ensure that specific demographic groups receive customized support to sustain their intrinsic capacity during their elder years.
A novel architecture for collaboration in systems biology at the age of the Metaverse
Authors: Jacopin Eliott , Sakamoto Yuki , Nishida Kozo , Kaizu Kazunari , Takahashi Koichi
Published: August 2023

The current state of the Metaverse is largely driven by corporate interests, which may not align with the scientific goals and values. Hence, academia should play a more active role in its development. In this paper, we present the challenges and solutions for building a Metaverse that supports systems biology research and collaboration. Our solution consists of two components: Kosmogora, a server ensuring biological data access, traceability, and integrity in the context of a highly collaborative environment such as a metaverse; and ECellDive, a virtual reality application to explore, interact, and build upon the data managed by Kosmogora. We illustrate the synergy between the two components by visualizing a metabolic network and its flux balance analysis. We also argue that the Metaverse of systems biology will foster closer communication and cooperation between experimentalists and modelers in the field.
Opening the wormhole: Linkages between justice in energy transitions and energy systems modelling literature – implications for policy development
Authors: Sefid N. , Okamoto T. , Doyon A. , Niet T.
Published: August 2023

Sometimes academics from different disciplines feel like they are working on different planets that orbit stars lightyears apart. Justice in energy transitions and the energy modelling literatures are no exception. While both fields share a common focus on realizing a sustainable and equitable future, rarely do equity and justice considerations enter modelling studies, and vice versa, rarely do papers consider modelling and engineering analysis enter into the justice in energy transitions field. This paper documents collaborative research conducted by justice in energy transitions and energy modelling researchers Through literature reviews and collaborative dialogue, we identified overlaps between justice in energy transitions and energy modelling and set an initial research agenda. By opening the wormhole connecting our fields, we hope to inspire more transdisciplinary research and inform future justice-oriented energy policy. We call on fellow justice in energy transitions and energy modelling researchers to join us in learning from one another and working towards a more sustainable and just future. We also call on policymakers to utilize transdisciplinary research to inform just energy futures.
Demand analysis of home care services among breast cancer survivors based on the Kano model
Authors: Zhang Mao-mao , Zhang Liu-liu , Zhi Xiao-xu , Cheng Fang , Yao Yu-feng , Deng Rong , Liu Chun-li , Wang Yan , Pei Yi
Published: August 2023

Purpose
Home-based nursing care services can effectively alleviate the pressure of medical and social services caused by the increasing number of breast cancer survivors. However, the precise definition and scope of home care services for breast cancer survivors remain unclear. The aim of this study was to explore the home care services for breast cancer survivors based on the Kano model to improve the quality of care services.
Methods
A convenience sampling was used to select breast cancer survivors from January 2023 to March 2023 in Jiangsu Cancer Hospital in Nanjing, Jiangsu Province, China. Participants completed a social demographic characteristics questionnaire, and their home nursing service needs were assessed using the Kano model. The home care attributes of the participants were categorized and described based on the Kano model.
Results
A total of 299 valid questionnaires (88.9%) were collected, evaluating 30 quality attributes of home care services. The findings revealed that 1 (3.3%) service was classified as "must-be quality" (body image management), 13 (43.33%) as "one-dimensional quality", 7 (23.33%) as "attractive quality" (focused on health management and guidance services), and 9 (30%) as "indifferent quality" (mainly in the area of psycho-social support).
Conclusion
Based on the Kano model, it was found that breast cancer survivors had different level of need for different home care service. Analyzing breast cancer survivors attitudes toward new service items for indifference quality will help service providers determine effective tactics in home care services.
Mechanical performance and swelling resistance of silicone rubber reinforced with γ- methacryloxypropyltrimethoxysilane modified halloysite nanotubes
Authors: K Govindan , S Ramabalan , S Vishvanathperumal
Published: August 2023

The halloysite nanotubes (HNTs) experienced a satisfactory surface treatment with γ-methacryloxypropyltrimethoxysilane (γ-MPS), which facilitated interaction with the aluminol and silanol groups found on the edges and surfaces of the nanotubes. The modified HNTs (mHNTs) were used to create silicone rubber vulcanizate nanocomposites. The modification of -MPS was used to improve the interactions between surfaces and tubules. This improvement led to a higher crosslinking density and better HNT dispersion inside the silicone rubber matrix. To assess the effect of mHNTs loading on various features of the resultant rubber nanocomposites, a comprehensive analysis was carried out. The following parameters were studied: cure characteristics, compression set, swelling behavior, abrasion resistance, and mechanical properties. To accomplish this, the oscillating disc rheometer (ODR), solvent immersion technique, DIN abrader, and tensile testing were employed for precise measurements. Overall, the characteristics and performance of the silicone rubber nanocomposites were significantly enhanced by the addition of mHNTs. This study demonstrates the efficacy of mHNTs as reinforcing agents and creates new avenues for strengthening silicone rubber-based material qualities in a variety of applications. The nanocomposites' tensile modulus, strength, and rip strength were all improved by the addition of mHNTs. Furthermore, the silicone rubber/mHNTs nanocomposites exhibit enhanced swelling resistance as a result of the powerful inter-tubular contact they possess. The obtained results were analyzed in relation to the microstructure of the samples, as examined through FESEM analyses.
Characterization and Static Responses of Partially Biodegradable Hybrid Composites: Experimental and Numerical Analysis
Authors: Rout Itishree , Mahapatra Trupti Ranjan , Mishra Debadutta , Parimanik Soumya Ranjan
Published: August 2023

The present work deals with the mechanical characteristics and deflection responses of novel partially biodegradable hybrid composites embracing an animal based (Human Hair), a plant based (Luffa Cylindrica) fiber (denoted as HHF and LCF) and Incense Stick Ash (ISA) under different loadings. Ultrasonicator assisted hand lay-up technique has been followed for the inhouse fabrication process by incorporating epoxy resin as the matrix material while varying weight ratios (0, 5, 10, 15, and 20 wt.%) of ISA filler. Firstly, the density, elastic properties through non-destructive Impulse Excitation Technique (IET), microhardness, strengths under tensile, bending and impact loading are obtained and the surface morphology of fractured surfaces is studied. The composite filled with 10 wt.% ISA shown the best overall tensile, bending and shear properties, while the highest flexural strength and microhardness is depicted by composite filled with 20 wt.% ISA. Subsequently, finite element (FE) analysis using a simulation model in ANSYS is employed to acquire the tensile and flexural strength, those are found to be comparable with the experimental values. Finally, a higher-order nonlinear FE model is developed and implemented using MATLAB programming platform to compute the static responses under different loads (point load, sinusoidally distributed line load, uniformly distributed line load, uniformly distributed load and sinusoidally distributed load) using the experimentally obtained composite material properties. The validity of the developed model has been tested by comparing the results with the data acquired through lab-scale experimentation. From the numerical illustrations, moderate ISA filled (10 wt.%) composites with higher aspect ratio and lower thickness ratio are observed to provide more significant resistance to deflection under static loading.
Research on Multi-model Mask Video Caption based on Transformer
Authors: Peng Yuqing , 姚 昊 , Ji Xinhao , Gao Xuan
Published: August 2023

Previous work on video caption has mainly focused on visual information in the video, neglecting the audio information. This differs from how humans perceive the world by simultaneously processing and integrating multiple modalities. This paper proposes a novel multimodal masked video captioning model (MMVC) that uses a new Transformer model to integrate both the audio modality, which contains rich semantic association information, and the masked video frame image modality. By studying different fusion stages and strategies, a new fusion strategy is proposed that improves model performance while reducing the computational cost. Experiments on the MSVD and MSR-VTT datasets show that the audio modality contains complementary information that effectively improves video caption performance and metrics.