bluuebunny/crossref_metadata_2025 huggingface dataset:
Circumstantial Insights into the Potential of Traditional Chinese Medicinal Plants as
a Therapeutic Approach in Rheumatoid Arthritis
Authors: Sharma Twinkle , Sharma Parth , Chandel Parteek , Singh Sukhbir , Sharma Neelam , Naved Tanveer , Bhatia Saurabh , Al-Harrasi Ahmed , Bungau Simona , Behl Tapan
Published: March 2022

The advanced era has invited a plethora of chronic and autoimmune infirmities unmistakably dominated
by rheumatoid arthritis, occurring because of equivocal causes, including ecological factors, genetic variations,
etc. Unfortunately, it is winning pretty much in every stratum of the society in the undefined age group
of the population. Engineered drugs are accessible for the treatment; however, they do experience adverse effects
as the treatment requires a prolonged duration worsened by noncompliance. To overwhelm it, certain
pharmacological and molecular pathways are explored in the wake of Chinese herbs that prompted the prevention
of this deteriorating autoimmune disease. The alcoholic extracts and decoctions are procured from Chinese
herbs, such as Paeonia lactiflora, Glycyrrhiza uralensis, Tripterygium wilfordii, etc., which have been proved to
manifest constructive pharmacological actions. The activities that were exhibited by extracts are significantly innocuous,
non-toxic, and potent to fix the affliction in contrast with the chemosynthetic drugs. Therefore, these Chinese
herbs bring forth potent anti-inflammatory, immune-suppressing, anti-nociceptive, anti-neovascularizing, free
radical scavenging activities, and various other benefits to withstand several pathological events that usually
endure infirmity. It can be abridged that Chinese herbs possess assorted and selective therapeutic properties
with profound safety and viability to treat this rheumatic disorder. Thus, this review aims to shed light on naturally
originated treatment that is pertinent to providing invulnerable therapy exonerating from adverse effects
by restraining joint deformities, production of auto-antibodies, and inflammation.
Liposome Nanoparticles as a Novel Drug Delivery System for Therapeutic
and Diagnostic Applications
Authors: Li Guiling , Meng Yanan , Niu Xia
Published: March 2022

Liposome nanoparticles (LNPs) as a promising platform in drug delivery, combine the advantages of both liposomes and inorganic/organic nanoparticles into a single system. Both liposomes and nanoparticles have demonstrated the optimized drug efficacy in clinic. LNPs are proven to be a multifunctional system and thus utilized in various research applications (e.g., spatiotemporal control of drug release, hyperthermia, photothermal therapy, and biological imaging). The type of nanoparticles involved in LNPs largely affects the features of LNPs. Besides, diverse nanoparticlesenable liposomes to overcome the defects such as poor stability, few functions and rapid elimination from blood circulation. In this review, multiple nanoparticles materials and further prepared LNPs as well as their structure, physicochemical properties, manipulation and the latest applications in biomedical field are introduced. Future directions in advancing of LNPs are also discussed in the end.

Liposome nanoparticles (LNPs), as a promising platform in drug delivery, combine the advantages
of both liposomes and inorganic/organic nanoparticles into a single system. Both liposomes
and nanoparticles have demonstrated optimized drug efficacy in the clinic. LNPs are proven to be multifunctional
systems and thus utilized in various research applications (e.g., spatiotemporal control of
drug release, hyperthermia, photothermal therapy, and biological imaging). The type of nanoparticles
involved in LNPs largely affects the features of LNPs. Besides, diverse nanoparticles enable liposomes
to overcome the defects such as poor stability, few functions, and rapid elimination from blood circulation.
In this review, multiple nanoparticles materials and further prepared LNPs as well as their structure,
physicochemical properties, manipulation and the latest applications in biomedical field are introduced.
Future directions in advancing of LNPs are also discussed in the end.
Diagnostic Dilemmas and Current Treatment Approaches in Latent Onset
Autoimmune Diabetes in Adults: A Concise Review
Authors: Vellapandian Chitra , Chandran Lakshmi , Singh S. Ankul
Published: March 2022

Latent Onset Autoimmune Diabetes in Adults (LADA) is an autoimmune disorder
between T1DM and T2DM and is often misdiagnosed as T2DM due to its late-onset. The disease
is characterized by β-cell failure and slow progression to insulin dependence. Early diagnosis is
significant in limiting disease progression. C-peptide levels and autoantibodies against β-cells are
the most critical diagnostic biomarkers in LADA. The review aims to provide an overview of the
biomarkers used to diagnose LADA, and the following treatment approaches. We have summarized
LADA's pathophysiology and the autoantibodies involved in the condition, diagnostic approaches,
and challenges. There are clear shortcomings concerning the feasibility of autoantibody
testing. Finally, we have explored the treatment strategies involved in the management of LADA.
In conclusion, the usual management includes treatment with metformin and the addition of low
doses of insulin. Newer oral hypoglycaemic agents, such as GLP-1RA and DPP-4 inhibitors, have
been brought into use. Since the disease is not entirely understood at the research level and in clinical
practice, we hope to encourage further research in this field to assess its prevalence. Large randomized
controlled trials are required to compare the efficacy of different available treatment options.
Dynamic Contrast-Enhanced MR Perfusion in Differentiation of Benign
and Malignant Brain Lesions
Authors: Aralasmak Ayse , Cetinkaya Ezra , Atasoy Bahar , Tokdemir Sevil , Toprak Huseyin , Toprak Ali , Kurtcan Serpil , Alkan Alpay
Published: March 2022

Background:

We aimed to differentiate Glioblastoma Multiforme (GBM) from benign lesions
like Developmental Venous Anomaly (DVA) and Cavernous Malformation (CM) by Dynamic
Contrast-Enhanced MR Perfusion (DCE-MRP) markers such as Ktrans, Ve, Kep, and IAUC.

Method:

We retrospectively evaluated 20 patients; 10 GBM as the malignant group, 5 CM and 5
DVA as the benign group. Ktrans, Kep, Ve, and IAUC parameters were measured by DCE-MRP, within
the lesion, at perilesional nonenhancing white matter (PLWM) and contralateral normal appearing
white matter (CLWM).

Result:

All benign and malignant lesions exhibited significantly increased Ktrans, Ve, and IAUC
values compared to PLWM and CLWM (p < 0.001, p=0.006 and p<0.001). Subtracted Kep values
between lesion and PLWM were significantly different between the benign and malignant groups, as
the malignant group exhibited higher subtracted Kep values (p 0.035). For the malignant group; Ktrans
and IAUC values at the lesion were positively correlated (r 0.911), while Kep and Ve at CLWM were
negatively and strongly correlated (r 0.798). For the benign group; Ktrans with Ve and Ktrans with
IAUC at lesion (r 0.708 and r 0.816 respectively), Ktrans and IAUC at PLWM (r 0.809), Ktrans and
IAUC at CLWM(r 0.798) were strongly and positively correlated. Ktrans, Ve, and IAUC values can be
used to restrict the lesion in both groups.

Conclusion:

Ktrans strongly correlates with IAUC and they can be used instead of each other in both
benign and malignant lesions. Classical DCE-MRP parameters cannot be used in the differentiation of
malignant lesions from benign vascular lesions. However, subtracted Kep values can be used to differentiate
GBM from benign vascular lesions.
Ramalin: A Multi-Mechanistic Lichen Metabolite of Pharmacological Importance
Authors: Katiyar Deepti , Bansal Priya , Kumar Abhishek , Prakash Surya
Published: March 2022

Background:

Ramalin (γ-glutamyl-N'-(2-hydroxyphenyl) hydrazide), a nitrogen containing lichen secondary metabolite was isolated decennium back from Ramalina terebrata, an Antarctic lichen. Since then it has attracted a number of researchers thus leading to various research investigations exploring the pharmacological potential of Ramalin in the past decade.

Methods:

The bibliographic databases were explored for the peer-reviewed research related to the pharmacological importance of Ramalin.

Results:

The article summarizes the antioxidant, anti-cancer, anti-obesity, antibacterial and anti-allergic activities of this molecule. Additionally, the studies conducted to show the potential of Ramalin in athercosclerosis, atopic dermatitis, neurodegenerative disorders, hepatic fibrosis and its role in autophagy suppression and enzyme inhibition are also described briefly. Moreover, the experimental findings also depict that Ramalin did not show any toxicity.

Conclusion:

The current review shall be very useful for the future researchers interested to work on Ramalin because it summarizes all the relevant publications starting
Potential Drug-Drug Interactions Between Anti-Cancer Drugs and Other
Medications in Lung Cancer Patients: A Retrospective Study
Authors: Rao Mahadev , Pinto Rosella Ayesha , Roy Arpita , Thomas Levin , Udupa Karthik S. , Guddattu Vasudeva
Published: March 2022

Background:

Cancer patients are more vulnerable to developing drug-drug interactions
as multiple medications are administered concomitantly with cytotoxic agents to treat the
underlying comorbidities. These drug-drug interactions often receive less medical attention and
consequently are associated with adverse clinical outcomes.

Objective:

We intended to comprehensively characterize the drug-drug interactions among
anticancer drugs and other concomitantly prescribed drugs in hospitalized lung cancer patients.

Methods:

A retrospective, observational, single-centre study was conducted on lung cancer
inpatients from the medical records department of Kasturba Hospital, Manipal, India. Drug-drug
interactions were identified using the drug interaction checkers of two drug information databases,
Micromedex and Epocrates. These drug-drug interactions were categorized based on the source
from which they were identified, mechanism, severity/significance, adverse consequences, and
management strategies required.

Results:

Among 196 patients, 555 drug-drug interactions were identified in 185 patients using
Micromedex and Epocrates. Based on the mechanism of action, 74% and 22% of the drug-drug interactions
were classified as pharmacodynamic and pharmacokinetic respectively. 112 drug-drug
interactions were recorded from Micromedex alone, while 549 interactions were found using
Epocrates. The oral chemotherapeutic drug gefitinib was found to be associated with the highest
number of drug-drug interactions.

Conclusion:

Drug-drug interactions were highly prevalent among hospitalized lung cancer
patients. Structured screening and monitoring for these potentially clinically relevant drug-drug
interactions by oncologists in collaboration with clinical pharmacists should be carried out prior to
initiation and during anticancer treatment to prevent adverse clinical outcomes.
Peimine Inhibits MCF-7 Breast Cancer Cell Growth by Modulating Inflammasome
Activation: Critical Roles of MAPK and NF-κB Signaling
Authors: Sun Jingqiu , Li Jing , Kong Xin , Guo Qingfeng
Published: March 2022

Objective:

Peimine (PM) is a bioactive compound obtained from Fritillaria. It has been documented that PM
exhibits potent antitumor properties against multiple cancers. However, the antitumor properties of PM in breast cancer
and its associated mechanisms have not been clarified.

Methods:

Proliferation and apoptosis of MCF-7 and MCF-10A cells were detected by CCK8, colony formation, and
flow cytometry assays. Cytotoxicity was measured by Lactate dehydrogenase (LDH) leakage assay. The level of IL-1β
and IL-18 were detected with ELISA kits. Western blotting and real-time Polymerase Chain Reaction were performed
to analyze the expression of proteins and genes related to the NLRP3 inflammasome pathway and Endoplasmic reticulum stress.

Reults:

The doses of PM (5, 10, and 20 µM) inhibited cell viability significantly, apoptotic induction, and inflammasome activation in breast cancer cells in vitro. Inflammasome components were decreased, including the apoptosisassociated speck like protein containing a CARD (ASC) and NOD-like receptor pyrindomain-containing protein3
(NLRP3), as well as the inhibition of caspase-1 and interleukin-1β activation. Moreover, inflammasome inhibitors
suppressed cell growth and induced apoptosis, implying that PM suppresses the growth of breast cancer cells through
regulating inflammasome. Mechanistically, PM inhibited the activity of inflammasome by alleviating endoplasmic
reticulum (ER) stress and by down-regulating the expression of multiple proteins in transcription factor nuclear factorκB (NF-κB) and mitogen-activated protein kinases (MAPKs) signaling pathways.

Conclusion:

These findings show that PM suppresses the growth of breast cancer cells by inhibiting inflammasome
activation, to a certain extent, by primarily acting on the MAPK/NF-κB pathway's inactivation-dependent mechanisms.
A Therapeutic Journey of Pyridine-based Heterocyclic Compounds as Potent Anticancer
Agents: A Review (From 2017 to 2021)
Authors: Alrooqi Munira , Khan Sikandar , Alhumaydhi Fahad A. , Asiri Saeed A. , Alshamrani Meshal , Mashraqi Mutaib M. , Alzamami Ahmad , Alshahrani Asma M. , Aldahish Afaf A.
Published: March 2022

Pyridine derivatives are the most common and significant heterocyclic compounds, which show their fundamental
characteristics to various pharmaceutical agents and natural products. Pyridine derivatives possess several
pharmacological properties and a broad degree of structural diversity that is most valuable for exploring novel therapeutic
agents. These compounds have an extensive range of biological activities such as antifungal, antibacterial, anticancer,
anti-obesity, anti-inflammatory, antitubercular, antihypertensive, antineuropathic, antihistaminic, antiviral
activities, and antiparasitic. The potent therapeutic properties of pyridine derivatives allow medicinal chemists to synthesize
novel and effective chemotherapeutic agents. Consequently, the imperative objective of this comprehensive
review is to summarize and investigate the literature regarding recent advancements in pyridine-based heterocycles to
treat several kinds of cancer. Furthermore, the performances of pyridine derivatives were compared with some standard
drugs, including etoposide, sorafenib, cisplatin, and triclosan, against different cancer cell lines. We hope this study
will support the new thoughts to pursue the most active and less toxic rational designs.
Mini Review on Cariprazine: A Promising Antipsychotic Agent
Authors: Patel Ashish , Patel Arya , Patel Darshini , Patel Krina , Bambharoliya Tushar
Published: March 2022

Cariprazine is a piperazine derivative approved by the USFDA in 2015 as a novel atypical antipsychotic drug (APD) to treat adults with schizophrenia and bipolar manic or mixed episodes in adults. However, due to the partial agonist action on dopamine D2, D3 receptors, and serotonin 5-HT1A receptors as well as the antagonist effect on 5-HT2A, 5-HT2B, and H1 receptors, cariprazine differs pharmacologically from other APDs, both typical and atypical. Moreover, cariprazine also has a unique pharmacokinetic profile due to the formation of two clinically significant metabolites: desmethyl-cariprazine (DCAR) and desmethyl-cariprazine (DDCAR). They are eliminated by CYP3A4 and also, to a lesser extent, by CYP2D6. Here, we also review the effectiveness, safety, as well as current clinical update of cariprazine in bipolar I disorder associated with/without mania and schizophrenia through randomized and post-hoc analysis. The potential benefits of cariprazine as a promising therapeutic alternative in addressing major clinical requirements for better therapy of such severe neuropsychiatric conditions were demonstrated in this summarized review study.
Emergent Ophthalmic Disease Knowledge among Non-Ophthalmologist Healthcare Professionals in the Western Region of Saudi Arabia: Cross-Sectional Study
Authors: Alsaedi Mohammed Ghazi , Alhujaili Haneen Omar , Fairaq Ghadeer Saleh , Alwdaan Sohad Ali , Alwadan Rwaa Ali
Published: March 2022

Background:

Patients with emergent ophthalmic diseases are likely to be examined by healthcare providers before an ophthalmologist, so it is essential that nonspecialists have adequate knowledge for recognition and preliminary diagnosis.

Objectives:

To assess knowledge of retinal detachment, acute angle-closure glaucoma, temporal arteritis, and central retinal artery occlusion among non-ophthalmologist healthcare professionals.

Methods:

We conducted an observational cross-sectional study of 351 healthcare workers, including medical residents, nurses, pharmacists, and optometrists, in western Saudi Arabia using a self-report questionnaire.

Results:

Total knowledge scores were 75.21% for retinal detachment and 74.9% for acute angle-closure glaucoma, but only 44.15% for temporal arteritis and 41.88% for central retinal artery occlusion. Stepwise logistic regression revealed that level of education was the most significant factor influencing knowledge of different eye diseases.

Conclusion:

Ophthalmologists are encouraged to promote greater awareness and provide other healthcare professionals with the knowledge required to recognize emergent eye diseases for early detection.
Immunomodulatory Therapeutic Effects of Curcumin on M1/M2 Macrophage
Polarization in Inflammatory Diseases
Authors: Azhdari Sara , Moghaddam Abbas Shapouri , Abdollahi Elham , Johnston Thomas P. , Ghaneifar Zahra , Vahedi Parviz , Goleij Pouya
Published: March 2022

Background:

Due to their plasticity, macrophages exert critical effects on both promoting and
suppressing inflammatory processes. Pathologic inflammatory conditions are frequently correlated with
dynamic alterations in macrophage activation, with classically activated M1 cells associated with the promotion
and maintenance of inflammation and M2 cells being linked to the resolution or smouldering of
chronic inflammation. Inflammation deputes a common feature of various chronic diseases and the direct
involvement in the insurgence and development of these conditions. Macrophages participate in an autoregulatory
loop characterizing the inflammatory process, as they produce a wide range of biologically
active mediators that exert either deleterious or beneficial effects during the inflammation. Therefore,
balancing the favorable ratios of M1/M2 macrophages can help ameliorate the inflammatory landscape
of pathologic conditions. Curcumin is a component of turmeric with many pharmacological properties.

Objective:

Recent results from both in-vivo and in-vitro studies have indicated that curcumin can affect
polarization and/or functions of macrophage subsets in the context of inflammation-related diseases.
There is no comprehensive review of the impact of curcumin on cytokines involved in macrophage polarization
in the context of inflammatory diseases. The present review will cover some efforts to explore
the underlying molecular mechanisms by which curcumin modulates the macrophage polarization in distant
pathological inflammatory conditions, such as cancer, autoimmunity, renal inflammation, stroke, atherosclerosis,
and macrophage-driven pathogenesis.

Result:

The accumulation of the findings from in vitro and in vivo experimental studies suggests that
curcumin beneficially influences M1 and M2 macrophages in a variety of inflammatory diseases with
unfavorable macrophage activation.

Conclusion:

Curcumin not only enhances anti-tumor immunity (via shifting M polarization towards M1
phenotype and/or up-regulation of M1 markers expression) but ameliorates inflammatory diseases, including
autoimmune diseases (experimental autoimmune myocarditis and Behcet's disease), nephropathy,
chronic serum sickness, stroke, and atherosclerosis.
FORMULATION OF PROPHETIC CHARACTERS AS THE BASE FOR ANTI-CORRUPTION EDUCATION IN UNIVERSITY
Authors: Chanifah Nur
Published: March 2022

This study aimed to formulate a prophetic character as a base for anti-corruption education so that it could provide some solutions in the development of anti-corruption education in university. Considering the effort to eradicate corruption through education is an inevitability in the midst of rampant corruption by a number of political elites. The method used was a literature review with data processing techniques including editing, classifying, and concluding. While the data analysis used content analysis with descriptive-qualitative data presentation type. The results showed that in relation to anti-corruption education in university, prophetic characters include four characteristics of the Prophet (Rasulullah), namely honest (shiddiq), trustworthy (amanah), communicative (tabligh), and intelligent (fathanah). These four characters are reflected in figures who always guide their conscience and truth, maintain professionalism and commitment, master communication skills with various groups and levels, and have the ability solve any problem.
Fostering Children’s Moral in a Pandemic Period in the Perspectif of Islamic Educational Psychology
Authors: Alghzali Reno Diqqi , Sa’adah Annas Fitria
Published: March 2022

Moral continued to be an issue that attracts attention. Especially now that various parts of the country are experiencing the Corona Virus Disease (Covid-19). The deadly virus requires people to carry out all activities from home, including learning and teaching at home. All parents are required to teach academically and morally. This article applies an exploratory case study method through a qualitative case study method approach that can find out information that occurs regarding Covid-19 on government policies that decide to carry out teaching and learning activities from home. The moral development in the perspective of Islamic psychology that can be done during this pandemic is by means of education with compassion, exemplary methods, and methods of advice.
A Bayesian Network to Predict the Risk of Post Influenza Vaccination Guillain-Barré Syndrome: Development and Validation Study (Preprint)
Authors: Huang Yun , Luo Chongliang , Jiang Ying , Du Jingcheng , Tao Cui , Chen Yong , Hao Yuantao
Published: March 2022

BACKGROUND

Identifying the key factors of Guillain-Barré syndrome (GBS) and predicting its occurrence are vital for improving the prognosis of patients with GBS. However, there are scarcely any publications on a forewarning model of GBS. A Bayesian network (BN) model, which is known to be an accurate, interpretable, and interaction-sensitive graph model in many similar domains, is worth trying in GBS risk prediction.

OBJECTIVE

The aim of this study is to determine the most significant factors of GBS and further develop and validate a BN model for predicting GBS risk.

METHODS

Large-scale influenza vaccine postmarketing surveillance data, including 79,165 US (obtained from the Vaccine Adverse Event Reporting System between 1990 and 2017) and 12,495 European (obtained from the EudraVigilance system between 2003 and 2016) adverse events (AEs) reports, were extracted for model development and validation. GBS, age, gender, and the top 50 prevalent AEs were included for initial BN construction using the R package bnlearn.

RESULTS

Age, gender, and 10 AEs were identified as the most significant factors of GBS. The posttest probability of GBS suggested that male vaccinees aged 50-64 years and without erythema should be on the alert or be warned by clinicians about an increased risk of GBS, especially when they also experience symptoms of asthenia, hypesthesia, muscular weakness, or paresthesia. The established BN model achieved an area under the receiver operating characteristic curve of 0.866 (95% CI 0.865-0.867), sensitivity of 0.752 (95% CI 0.749-0.756), specificity of 0.882 (95% CI 0.879-0.885), and accuracy of 0.882 (95% CI 0.879-0.884) for predicting GBS risk during the internal validation and obtained values of 0.829, 0.673, 0.854, and 0.843 for area under the receiver operating characteristic curve, sensitivity, specificity, and accuracy, respectively, during the external validation.

CONCLUSIONS

The findings of this study illustrated that a BN model can effectively identify the most significant factors of GBS, improve understanding of the complex interactions among different postvaccination symptoms through its graphical representation, and accurately predict the risk of GBS. The established BN model could further assist clinical decision-making by providing an estimated risk of GBS for a specific vaccinee or be developed into an open-access platform for vaccinees’ self-monitoring.
Value Cocreation in Health Care: Systematic Review (Preprint)
Authors: Peng Yuxin , Wu Tailai , Chen Zhuo , Deng Zhaohua
Published: March 2022

BACKGROUND

Value cocreation in health care (VCCH), mainly based on service-dominant logic, emphasizes that participants, including both patients and physicians, can effectively enroll in the health care value creation process. Effective VCCH is of great significance for realizing value-based health care and improving doctor-patient relationships. Therefore, a comprehensive understanding of VCCH is critical. However, the current literature on VCCH is fragmented and not well studied.

OBJECTIVE

The goal of the research is to investigate the antecedents, consequences, and dimensions of VCCH by systematically searching, selecting, summarizing, and evaluating relevant literature.

METHODS

English-language articles on VCCH in the Web of Science, PubMed, and Scopus databases published from January 2008 to December 2019 were identified. The articles were screened using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses protocol, and the quality of studies included were appraised using the Mixed Methods Appraisal Tool.

RESULTS

Out of the 181 publications initially identified through the bibliographic searches, 28 publications met the inclusion criteria. This review summarizes antecedents, consequences, and dimensions of VCCH, as well as possible associations among them. An integrative framework is also proposed for mapping the literature of VCCH grounded on social cognitive theory to reveal the whole process of VCCH.

CONCLUSIONS

The findings of this systematic review provide implications for continued development of VCCH and contribute to inspire more research in the future.
Engagement with HIV and COVID-19 prevention within a geosocial networking app: a tale of two pandemics (Preprint)
Authors: Gaither Thomas , Sigalos John , Landovitz Raphael , Mills Jesse , Litwin Mark , Eleswarapu Sriram
Published: March 2022

BACKGROUND

Geosocial networking (GSN) apps play a pivotal role in catalyzing sexual partnering, especially among men who have sex with men (MSM).

OBJECTIVE

To quantify the United States (US) prevalence and disparities in disclosure of pre-exposure prophylaxis (PrEP) use and COVID-19 vaccination among GSN app users, mostly MSM.

METHODS

We randomly sampled online Grindr profiles from the top 50 metropolitan areas as well as the 50 most rural counties in the US by population. Grindr provides an option to disclose current PrEP use (HIV positive, HIV negative, or HIV negative with PrEP use). We analyzed the free text in all profiles and recorded any mention of COVID-19 vaccination, which is passively reported. We performed multivariable logistic regression to assess independent associations with PrEP disclosure and COVID-19 vaccination. We used imputation analyses to test the robustness of the results.

RESULTS

We evaluated 1,889 urban and 384 rural profiles. Mean age among urban profiles was 32.9 years (SD 9.6); mean age among rural profiles was 33.5 years (SD 12.1), p=0.41. Among the urban profiles, 16% reported being vaccinated against COVID-19 and 23% reported PrEP use compared to 10% and 8% in rural profiles, respectively (p<0.01). Reporting COVID-19 vaccination (adjusted OR 1.7, 95%CI 1.2-2.4), living in an urban center (aOR 3.2, 95%CI 1.8-5.7), and showing a face picture as part of the Grindr profile (aOR 4.0, 95%CI 2.3-7.0) were positively associated with PrEP disclosure. Self-identified Black and Latino users were less likely to report PrEP use (aOR 0.6, 95%CI 0.4-0.9 and aOR 0.5, 95%CI 0.4-0.9, respectively). Reporting PrEP use (aOR 1.7, 95%CI 1.2-2.4), living in an urban center (aOR 2.5, 95%CI 1.4-4.5), ‘discreet’ status (aOR 1.6, 95%CI 1.0-2.5), and showing a face picture (aOR 2.7, 95%CI 1.5-4.8) were positively associated with reporting COVID-19 vaccination on the profile. Users in the southern US were less likely than users in the northeast to report COVID-19 vaccination (aOR 0.6, 95%CI 0.3-0.9).

CONCLUSIONS

Variations in PrEP disclosure are associated with race, whereas COVID-19 vaccination disclosure is associated with geographic area. However, rural GSN users were less likely to report both PrEP use and COVID-19 vaccination. We demonstrate a need to expand health preventative services in the rural US for sexual minorities. GSN platforms may be ideal for deployment of preventative interventions to improve access for this difficult to reach population.

CLINICALTRIAL

n/a
México y la UNESCO: cómo mejorar esta relación
Authors: Latapí Sarre Pablo
Published: March 2022

Reconociendo los aspectos positivos, en el orden diplomático y político, de la relación que México ha tenido con la UNESCO, el ensayo señala que esta relación no es tan productiva como debiera –en el sentido tanto de obtener de la UNESCO conocimientos beneficiosos para enriquecer nuestras políticas educativas y culturales, como de ofrecer al organismo nuestras experiencias valiosas. Esto se debe, se arguye, a la falta de políticas específicas claramente definidas. La ausencia de políticas se debe, a su vez, a un conflicto de competencias entre la Secretaría de Relaciones Exteriores y la de Educación Pública, y a la manera como está conformada la Comisión Nacional de Cooperación ante la UNESCO. Se comentan las consecuencias indeseables de esta situación y se sugiere un procedimiento para superarla.
Ciberespacio y Cibermundo: delimitaciones conceptuales desde el materialismo sistémico
Authors: Santana-Soriano Edwin , Báez Vizcaíno Katherine
Published: March 2022

En este artículo se presenta una delimitación de los conceptos ciberespacio y cibermundo desde una perspectiva materialista sistémica emergentista. Para ello, se recurrió a un análisis teórico crítico de investigaciones previas en el que se evalúan las propuestas precedentes que han contribuido a la construcción de los conceptos en la forma en que son utilizados actualmente, pero que contienen una carga de vaguedad que, a la vez que pasa inadvertida, dificulta que se les dé un tratamiento científico riguroso. Se presenta, además, una caracterización original del cibermundo en la que se incluye un acercamiento a las posibles relaciones sociales que se dan a lo interno de los ciberespacios, y se propone un concepto de ciberespacio pluralizable que tiene en cuenta la posible emergencia de otros ciberespacios a partir de otras configuraciones materiales o con otros atributos distintos a los que ahora se conocen. Así mismo, se propone la utilización del concepto de cibermundo como un concepto emergente que da cuenta de la convergencia entre ciberespacios, las relaciones ciberespaciales (tanto a lo interno de cada ciberespacio como entre los distintos ciberespacios), y de la cibercultura que resulta e interactua con la cultura del mundo natural. El artículo abre diferentes líneas de investigación sobre las estructuras internas ciberespaciales, su clasificación y tipificación, así como sobre las posibles implicaciones éticas y ciberculturales; de igual modo, constituye una fundamentación para una ciencia cibersocial de base materialista emergentista.
Analisis Pengaruh Jumlah Industri, Nilai Investasi, Dan Nilai Produksi Terhadap Penyerapan Tenaga Kerja Sektor Industri Kecil Dan Mikro Di Jawa Timur
Authors: Dewi Melia Kusuma , Syaifullah Yunan
Published: March 2022

The economic development of a country or region is basically closely related to human resources, natural resources, technology, capital, and others. The role of humans is very important to manage, develop and develop their regions both economically and with workforce readiness. The success of regional economic development can be measured by high economic growth and increased employment. The economic growth approach is widely used in several regions in developing regional economic sectors which are expected to increase employment. The absorption of Regency and City workers in East Java shows that they are in the medium category, the lowest employment is in Batu City as many as 20,000 workers throughout 2016-2020. The number of IKM, Regency and City businesses in East Java is in the medium category, namely 18 districts and cities from 37 districts and cities. There are 8 districts and cities in the high category where the largest number of IKM companies are in Malang district with a total of 39,970 companies. Meanwhile, judging from the investment value in the medium category, only Malang and Surabaya regencies are included in the high category. And the production value there are 5 districts and cities with a high category where Malang Regency is one of the largest with an average of 8.177.
Peran Pemerintah dan Masyarakat dalam Melestarikan Situs Cibuaya sebagai Cagar Budaya di Kabupaten Karawang
Authors: Qodariah Lelly , Sadiah Sadiah
Published: March 2022

Penelitian bertujuan untuk mengetahui peran Pemerintah dan masyarakat dalam melestarikan Situs Cibuaya sebagai cagar budaya di Kabupaten Karawang. Metode yang digunakan dalam penulisan penelitian ini adalah metode kualitatif yang dapat memaparkan dengan jelas kenyataan dilapangan. Pengumpulan data dilakukan dengan wawancara, observasi, dokumentasi. Setelah data terkumpul lalu dianalisis dengan teknik Triangulasi data dengan menerapkan model analisis interaktif dari Miles dan Heberman, yang terdiri dari tiga komponen terkait yaitu reduksi, sajian data dan verifikasi atau simpulan data. Hasil yang diperoleh dari penelitian ini bahwa Di desa Cibuaya pada masa lalu pernah berdiri sebuah kerajaan besar yaitu Kerajaan Tarumanegara dengan raja yang pernah berkuasa saat itu adalah Purnawarman, hal ini dilihat dari hasil penemuan dari benda-benda bersejarah seperti Arca Wisnu Cibuaya I dan II, batu pipisan, percandian lemah duhur dan sebagainya.
Phytochemical Screening, GCMS Profile, and In-silico properties of Bioactive Compounds in Methanolic Leaf Extracts of Moringa oleifera
Authors: Kandeepan C. , Sabitha M. , Parvathi K. , Senthilkumar N. , Ramya S. , Boopathi NM. , Jayakumararaj R.
Published: March 2022

Plant Based Natural Products (PBNPs) have been subject of interest since ancient time due to their use in food, industrial and biomedical applications. Research attention has further augmented to explore their phytochemical composition, properties, and potential application in the post-COVID era. In the present study phytochemical screening has been carried out with Methanolic Leaf Extracts of Moringa oleifera (MLEMO) followed by Gas Chromatography-Mass Spectrometry (GCMS) analysis. Phytochemical analysis of MLEMO revealed the presence of Alkaloids, Carbohydrates, Coumarins, Flavonoids, Glycosides, Phenol, Proteins, Quinones, Saponins, Steroids, Tannins and Terpenoids. Further, GCMS analysis revealed the presence of 41 compounds of which Dihydroxyacetone; Monomethyl malonate; 4H-Pyran-4-one,2,3-dihydro-3,5-dihydroxy-6-methyl; 1,3-Propanediol, 2-ethyl-2-(hydroxymethyl); Propanoic acid, 2-methyl-, octyl ester; 3-Deoxy-d-mannoic lactone; Sorbitol; Inositol; Cyclohexanemethanol, alpha-methyl-4-(1-methylethyl), Hexadecanoic acid, Methyl palmitate; n-Hexadecanoic acid (Palmitic acid); 9-Octadecenoic acid, methyl ester; Phytol; 9,12,15-Octadecatrienoic acid; Octadecanoic acid; 9-Octadecenamide were prominent. Most of the compounds in the list are bioactive and possess medicinal properties that are expected to serve as a baseline lead for the development of therapeutic agents.

Keywords: Phytochemical screening; GCMS; Bioactive Natural Products; Moringa oleifera; MLEMO; Biomedical application
Total triterpene content, antioxidant activity and acute toxicity study of Securidaca longepedunculara Fresen
Authors: Karama Issa , Ouedraogo Vincent , Rouamba Ablassé , Compaoré Moussa , Kiendrebeogo Martin
Published: March 2022

Plants are widely used in developing countries for traditional medicine. Knowledge of biological activities and phytochemistry is necessary for the safe use of these plants in traditional medicine. Securidaca longepedunculata is a medicinal plant whose roots are widely used in the treatment of several diseases. In this study the content of total triterpenes in leaf and root bark was assessed. The antioxidant activity by the ABTS method was evaluated as well as the effect of the extracts on lipid peroxidation of mice liver cell membranes. Acute toxicity was evaluated at the dose of 2000 mg / mL administered to the mouse. The results showed that the maximum values of the triterpenes contents of the leaves and of the root bark are 58 and 21 mg UAE / 100 mg respectively. Methanolic and chloroform extracts from leaves and root bark inhibited more than 50% of lipid peroxidation. The same extracts showed strong ABTS cation reduction activity. The leaf extract did not induce signs of acute toxicity in mice at a dose of 2000 mg / mL. The leaves of S. longepedunculata could be used in the management of pathologies associated with oxidative stress or which require biological properties relating to triterpene compounds.

Keywords: Securidaca longepedunculata, triterpenes, peroxidation, toxicity
Load study of the linear-extended structures when using crimping devices
Authors:   Academician I.G. Petrovskii Bryansk State University, Khimich A.V. , Artyomova A.A. ,   Academician I.G. Petrovskii Bryansk State University, Perminova D.I. ,   Academician I.G. Petrovskii Bryansk State University, Lagerev Igor ,   Academician I.G. Petrovskii Bryansk State University
Published: March 2022

The article presents scientific approaches to the study of the stress-strain state of linearly extended structures containing crimping devices. Examples of such structures include rope systems, pipelines for transporting media under pressure. The study of the stress-strain state of a gas pipeline on which a steel coupling used for the repair of substructures is installed is considered in detail.
Thermal diagnosis system of belt conveyors
Authors:   Bryansk State Technical University, Goncharov K.A.
Published: March 2022

Belt conveyors are one of the most difficult objects of technical condition diagnostics due to the interaction of elements of the work process of various genesis on extended sections of the routes: bulk cargo — elastic load-carrying belt — rigid load-bearing structures. Differences in the nature of the origin and the features of the mechanical operation of these elements suggest the presence of a differentiated approach to diagnosing the technical condition of belt conveyors when operating with the use of specific equipment. At the same time, in modern industrial conditions, diagnostic methods based on new or previously unused physical phenomena are widely used. The article is the first to propose a system for thermal diagnostics of units, assemblies and elements of belt conveyors, based on the results of a number of experimental studies. The advantages and disadvantages of thermal diagnostics of transporting machines in motion are shown. The basic provisions of thermal diagnostics are proposed, which make it possible to harmoniously integrate the proposed system into a well-established set of measures for monitoring the technical condition of belt conveyors at the stages of installation and operation in the form of additional recommendations and reporting documents. The results of experimental studies of the working processes of belt conveyors by the method of thermal diagnostics are generalized and element-by-element recommendations for conducting thermal control are developed, combined into a general method.
A general approach to the creation of digital twins of mobile ropeways based on mobile transport and reloading rope units
Authors:   Academician I.G. Petrovskii Bryansk State University, Lagerev Alexander , Lagerev Igor ,   Academician I.G. Petrovskii Bryansk State University
Published: March 2022

The article considers the conceptual approach and practical aspects of creating digital twins of mobile ropeways formed by two end mobile transport and reloading rope units based on self-propelled multi-axle wheeled chassis of high load capacity and cross-country ability. The approach is based on a systematic representation and analysis of the design and operating modes of a mobile ropeway. As a consequence, the digital twin is formed as a multilevel hierarchical structure. It combines information mathematical models of various functional purposes and varying degrees of mutual connectivity, which are distributed by levels depending on the degree of complexity and the possibility of their further aggregation into information mathematical models of a higher level. In relation to a typical mobile ropeway, a structural and functional analysis was carried out, on the basis of which its basic components were established, and calculated structural elements (technical devices and systems) were determined, requiring the development of the necessary individual information mathematical models. Approaches to aggregation of several individual models of computational elements connected by common characteristic quantitative parameters of modeling into group information mathematical models, and then into mode and complete information mathematical models of structural and functional components of a mobile ropeway are considered. The system approach considered in the article and the multilevel hierarchical structure of the digital twin developed on its basis are useful and effective from the point of view of ensuring the modularity of creating a digital twin, its modification for mobile ropeways of a different design, the possibility of using previously developed information mathematical models for similar computational structural elements.
ANÁLISE DE ACIDEZ TITULÁVEL, VERIFICAÇÃO DA PRESENÇA DE AMIDO E QUANTIFICAÇÃO DE FOSFATOS EM LINGUIÇAS COLONIAIS COMERCIALIZADAS NO MUNICÍPIO DE LAJEADO – RS
Authors: Weber Ani Caroline , Costa Bruna , Herber Jane
Published: March 2022

A linguiça colonial é o produto cárneo elaborado a partir da carne suína que possui uma ou mais de suas etapas realizadas em propriedades rurais. Por ser um alimento amplamente consumido e altamente suscetível a contaminações microbianas, deve haver um controle de qualidade rigoroso. Dentre os parâmetros que influenciam na qualidade e adequabilidade das linguiças coloniais, estão os teores de acidez, fosfatos e amido. Sendo assim, este trabalho teve por objetivo determinar a acidez total, verificar a presença de amido e quantificar o teor de fosfatos em amostras de linguiças coloniais comercializadas no município de Lajeado – Rio Grande do Sul. A acidez total e o teor de fosfatos foram determinados por meio de titulação e o teor de amido pelo método qualitativo utilizando-se lugol. Observou-se que todas as amostras possuíam baixa acidez total, o que as torna altamente propícias a contaminações microbiológicas. Não foi identificada presença de amido nas amostras, o que permite dizer que estão de acordo com a legislação, neste quesito. Para os fosfatos, todas as amostras estavam com teores acima do permitido pela regulamentação para o produto (0,5%). A fim de garantir a segurança alimentar conclui-se que há necessidade de um maior controle no que se refere ao teor de fosfato e acidez total no produto analisado, buscando um produto de qualidade para o consumo.
History of the Text of the 3rd and 4th Books of And Quiet Flows the Don
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Vorontsova Galina N.
Published: March 2022

M.A. Sholokhov was working on the third and the fourth books of the novel And Quietly Flows the Don — the ones dedicated to the events on Don during 1918−1920 — from the late 1920s to the late 1930s. The publication of the books was connected with a whole range of dramatic circumstances, which are the subject of the present article. The emphasis is placed on the textual evolution of the novel’s third and fourth books (which are the final ones and were repeatedly reproduced in various editions), as well as on the problem of their main textual source.
M.A. Sholokhov in the public Consciousness of Contemporaries
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Dvoryashin Yury A.
Published: March 2022

The article is dedicated to the problem concerning how M.A. Sholokhov’s personality and literary works were treated by the writer’s contemporaries at the different chronological stages of public consciousness — from the end of the 1920s to the 1970s.
PENGUATAN SELF-ESTEEM DALAM PEMBELAJARAN MATEMATIKA MELALUI PENDEKATAN PROBLEM SOLVING
Authors: Ginanjar Ilham , Fitriah Aidah
Published: March 2022

The background of the research is the low ability of students in self-esteem, so this study has the aim of comparing the application of problem solving approaches with scientific learning in strengthening self-esteem in learning mathematics. The research method used is quasi-experimental with a population of all SMP/MTs students in West Bandung Regency, with a sample of two classes in one of the SMP/MTs in West Bandung Regency. The instrument used is in the form of a questionnaire based on the Likert scale and then the data is analyzed using the two-mean similarity test. The results showed that the significance value of the two-mean similarity test was 0.00 so that it can be concluded that the self-esteem ability of students who learn using problem solving is better than those who learn using a scientific approach at a significance level of 5%.
La Investigación en la UTP y algunos de sus resultados. En las Facultades de Educación, Bellas Artes, Tecnología y Ciencias
Authors: Ballesteros Jaime Andrés , Carillo Holguín Luis Fernando , Falcón Tomé María del Carmen , Vanegas Lotero Carmen Elisa , Ariza Echeverri Edwan Anderson , Mesa Grajales DairoHernán , Tschiptschin André Paulo , Salazar Marín Edgar Alonso , Mesa Montoya Carlos Andrés , Montaño Acevedo Carlos Mario , Gómez Suta Manuela , Echeverry Correa Julián D. , Soto Mejía José A. , Correa Ramírez Jhon Jaime , Gil Pérez Anderson Paul , López García Edwin Mauricio
Published: March 2022

La Universidad Tecnológica de Pereira a través de la Vicerrectoría de Investigaciones, Innovación y Extensión tiene como propósito “Definir y direccionar los lineamientos para la investigación institucional que fortalezcan los grupos y semilleros de investigación, a través de la formación de investigadores, el desarrollo de programas o proyectos de ciencia, tecnología e innovación, así como la generación de redes y alianzas estratégicas que contribuyan a la creación y apropiación del conocimiento para la sociedad.” Y es por ello que, anualmente se realiza la CONVOCATORIA PARA FOMENTAR LA PUBLICACIÓN DE CAPÍTULOS DE LIBRO RESULTADO DE INVESTIGACIÓN - GRUPOS DE INVESTIGACIÓN, en la cual pueden postular los resultados de los proyectos de investigación finalizados en los últimos cinco años. En esta oportunidad, se publicarán capítulos de cuatro Facultades: Ciencias de la Educación, Bellas Artes y Humanidades, Tecnología y Ciencias Empresariales, en los cuales se darán a conocer los resultados obtenidos en proyectos de investigación realizados por sus grupos en diferentes temáticas.
Surgical management and pathological correlations: imaging findings suspicious for early-stage gallbladder cancer
Authors: Spartz Ellen , Wheelwright Matthew , Mettler Tetyana , Amin Khalid , Azeem Nabeel , Hassan Mohamed , Ankeny Jacob , Harmon James
Published: March 2022

Gallbladder cancer is a rare but potentially fatal disease. It is often
asymptomatic in early stages and is frequently found incidentally or
during the workup for benign biliary disease. We present two patients
who each had suspicious gallbladder imaging findings and highlight their
differences on radiologic and pathologic examination.