bluuebunny/crossref_metadata_2025 huggingface dataset:
Ischemic necrosis of proximal gastric remnant following subtotal gastrectomy with splenectomy
Authors: Isabella V. , Marotta E. , Bianchi F.
Published: February 2007

Ischemic necrosis of the gastric remnant is a rare and serious complication of high subtotal gastrectomy, rarely of the distal resection of the stomach. The authors report one case after subtotal gastrectomy with splenectomy, review the literature about this subject, and suggest that in all procedures the surgeon must take full account of the variability of gastric blood flow. Conservative therapy of this complication with total parenteral nutrition is proposed.
Multilocular cystic renal adenocarcinoma: A case report and review of the literature
Authors: Takeuchi T. , Tanaka T. , Tokuyama H. , Kuriyama M. , Nishiura T.
Published: February 2007

A case of multilocular cystic renal adenocarcinoma is presented. Although the multilocular renal cyst is an uncommon lesion, nine cases of these lesions associated with adenocarcinoma have been reported in the English literature so far. The related reports are reviewed in addition to three cases in the Japanese literature.
Bronchobiliary fistula after hepatic resection for metastatic colon cancer
Authors: George Timothy K. , Carignan Joanne R.
Published: February 2007

A patient is described with colon cancer and liver metastases who developed a bronchobiliary fistula 2 years after hepatic resection. The diagnostic approach and clinical management are presented and the literature is reviewed.
Bile duct tumours: Prolonged survival by radiological management of T‐tubes
Authors: Gordon Roy L. , Bloom Ronald A. , Engelberg M. , Weshler Z.
Published: February 2007

Carcinoma of the common bile duct is generally a slow‐growing tumour which causes death by hepatic failure and ascending cholangitis secondary to obstruction. Internal drainage by surgical placement of a T‐tube bypassing the tumour is widely employed, but survival times are generally short, averaging 9.9 months. The interventional radiologist can offer considerable prolongation of life with reduced hospitalization by means of percutaneous tube cleaning and catheter replacement. A case is presented where survival has been prolonged to 37 months by routine radiological catheter care.
Successful immunotherapy in a murine metastasizing fibrosarcoma model
Authors: Cortes Ruben , Correa Luis A. , Behbehani Abdulla I. , Sonis Stephen T. , Wilson Richard E.
Published: February 2007

Antigenic differences were demonstrated between the primary murine fibrosarcoma and its metastases. Immunization with irradiated primary tumor cells (TC) protected C57B1/6J mice against subsequent challenge with those cells, but not against challenge with cells from pulmonary metastases (PMC). Mice immunized with irradiated PMC were protected from challenge with those cells, but not against challenge with TC. Mice with fibrosarcomas produced by the injection of 5 × 103 cells from the primary tumor were treated by resection of the tumor‐bearing limb (Amp), Amp plus cylcophosphamide (Amp+Cy), Amp plus primary TC (Amp+TC), Amp plus primary TC and from its metastatic variant (Amp + TC + PMC), and with combinations of the last two groups with Cy. Although Amp+Cy improved survival, no animal lived 100 days and metastases increased as compared to controls. Immunotherapy significantly improved survival and decreased pulmonary metastases. Antigen combinations from primary and metastatic tumors resulted in significantly better survival than did a single preparation only from TC. Chemotherapy did not enhance the results obtained with immunotherapy and surgery. Immunity conferred in long‐term survivors was permanent.
Plasma histaminase activity in carcinoma of the cervix—Its clinical significance
Authors: Birdi Ashwi , Gupta Saroj , Gambhir S. S.
Published: February 2007

Plasma histaminase activity has been estimated in 79 patients with squamous cell carcinoma of the cervix. The mean plasma histaminase value is significantly higher in patients than in controls (P < 0.001). The plasma histaminase activity falls significantly following radiotherapy (P < 0.001). Pretreatment plasma histaminase values do not show any correlation with clinical stages and the posttreatment values decline significantly but remain higher in clinical stages III and IV than in stages I and II. The increased plasma histaminase activity also reflects the degree of differentiation within the tumor. Further it is noted that the plasma histaminase value is inversely proportional to the radiation response. It is suggested that estimation of plasma histaminase activity can serve as an important marker in assessing the treatment response and monitoring the course of treatment.
Disseminated Kaposi's sarcoma in a patient with acquired ichthyosis
Authors: Bechtel Mark A. , Callen Jeffrey P.
Published: February 2007

An elderly black male with Kaposi's sarcoma of the skin and lymph nodes is presented. The patient developed several violaceous papules involving the nose, which suggested a diagnosis of sarcoidosis clinically but proved to be Kaposi's sarcoma on biopsy. His clinical course was complicated by the development of acquired ichthyosis. The prognosis and treatment of generalized Kaposi's sarcoma is discussed.
The effect of malignant epithelial tumors, surgical therapy, and bacterial sepsis upon various parameters of interferon system
Authors: Ikossi‐O'connor M. C. , Chadha Kailash C.
Published: February 2007

The influence of tumor load, surgical trauma, and bacterial sepsis upon the ability of patient's peripheral leukocytes to produce interferon‐α (IFN‐α), the detectable serum IFN levels and circulating serum IFN inactivators were studied. Peripheral blood leukocytes of patients with solid tumors had significantly reduced ability to produce IFN‐α. Complete resectional surgery resulted in restoration of their ability to produce normal IFN‐α levels. Circulating IFN levels were detectable in 70% of patients with localized disease while only in 20% of patients with metastatic disease. Interferon‐α activators were detected in 45% of all patients. Both circulating interferon and IFN‐α inactivators became undetectable upon tumor resection. Surgical trauma is accompanied by a transient but definite decrease in IFN‐α production capability. Bacterial sepsis during postoperative days, in patients who successfully recovered, was definitely accompanied by increase in IFN‐α production capability. Our findings suggest that advanced malignant epithelial tumors have an adverse effect upon the patient's ability to produce interferon and are often accompanied by the presence of circulating serum interferon inactivators. These effects can be reversed by surgical resection of the malignant neoplasm.
Improved tissue perfusion during pressure‐regulated hyperthermic regional isolated perfusion in dogs
Authors: Fontijne W. P. J. , De Vries J. , Mook P. H. , Elstrodt J. M. , Oosterhuis J. W. , Koops H. Schraffordt , Oldhoff J. , Wildevuur C. R. H.
Published: February 2007

To achieve adequate tissue perfusion during regional isolated perfusion, hind limbs of dogs were perfused for 60 min, regulating the extracorporeal circuit on pressure. The dogs were divided into three groups. In groups I and II perfusions were performed at a delta pressure (systemic mean arterial pressure minus hind limb mean arterial pressure) of respectively 50 and 15 mm Hg; in group III delta pressure was also 15 mm Hg but the cytostatic drug Melphalan was added. Tissue perfusion was determined by means of a multiwire polarographic oxygen electrode. Adequate tissue perfusion was obtained only at subnormal perfusion pressures (groups II and III), although in all groups perfusion flow was higher than preoperative flow. At low perfusion pressures (group I), tissue perfusion was severely impaired. In all groups leakage remained less than 10%. During regional isolated perfusion the extracorporeal circuit must be regulated at a delta pressure of 15 mm Hg to achieve adequate tissue perfusion.
A trial of adjuvant combination chemoimmunotherapy for stage III carcinoma of stomach
Authors: Akiyoshi Tsuyoshi , Kawaguchi Michihiro , Arinaga Shinya , Miyazaki Soichiro , Koba Fumio , Wada Tetsuya , Tsuji Hideo
Published: February 2007

A chemoimmunotherapy program designed on the basis of experimental results was administered to 27 patients with stage III carcinoma of stomach following curative resection. The treatment regimen consisted of active immunotherapy with Vibrio cholerae neuraminidase (VCN)‐treated autologous tumor cells admixed with bacillus Calmette‐Guérin (BCG) and chemotherapy with drugs such as cyclophosphamide (CY), mitomycin C (MMC), and 5‐fluorouracil (FU) which proved to enhance the immune response when administered at optimal dose and timing. Then, it was followed by long‐term administration of tegafur (FT) and immunomodulators. This treatment significantly improved survival when compared to that of 41 historical control patients treated with surgery alone (P < 0.001). As compared to 31 control patients concurrently treated with a bolus dose of MMC followed by long‐term FT and immunomodulators, survival had a tendency, but not significantly, to be improved in patients treated with this therapy (P < 0.1). However, the survival rate at 4.5 years was significantly higher than that of control patients (P < 0.01). These results appeared to show that this type of adjuvant combination chemoimmunotherapy may be of benefit for this group of patients with gastric carcinoma.
Failure of subcutaneous mastectomy to prevent the development of breast cancer
Authors: Goodnight James E. , Quagliana Joseph M. , Morton Donald L.
Published: February 2007

Three patients treated with bilateral subcutaneous mastectomies and implants for fibrocystic disease or carcinoma in situ subsequently developed invasive breast carcinoma. These cases emphasize that subcutaneous mastectomy does not prevent the development of breast cancer. If the circumstances in an individual patient justify prophylactic mastectomy, then the appropriate procedure would seem to be total mastectomy, which would accomplish thorough removal of all breast tissue, the subareolar region, and the nipple. Subcutaneous mastectomy for the patient who is likely to harbor occult invasive disease seems particularly inappropriate. As a means to reduce the risk of breast cancer, the procedure is unproved and must be considered an experimental therapeutic approach.
Gastric cancer in young patients
Authors: Ikossi‐O'connor M. G. , Douglass H. O.
Published: February 2007

A retrospective review of the Roswell Park Memorial Institute experience and literature review of gastric carcinoma in young adults reveals that long‐term survival is rarely achieved. The primary correctable cause of failure is a very long delay in diagnosis, a result of both reluctance to initiate diagnostic studies and inaccuracy of routine upper gastrointestinal series. A high index of suspicion and liberal utilization of gastroscopy and gastric cytology combined with an aggressive surgical approach to gastric pathology would probably lead to improved survival for the young gastric carcinoma patients.
Local control in advanced head and neck cancer by combined modalities of treatment
Authors: Jose Baby , Desmukh Yusuf , Sharma Subhash C.
Published: February 2007

From July 1979 to January 1983, 20 patients with locally advanced head and neck cancer were treated with a combination of chemotherapy and irradiation with or without surgery. A majority of the patients were in the age range of 45 to 54 years. Eighty‐five percent of the patients were male. Seventy‐five percent of the patients had oral cavity lesions, the tongue being the most common site. Eighty percent of the patients had T4 lesion and 35% had N3 disease in the neck. A majority of the patients had combination chemotherapy, including bleomycin, methotrexate, and cis‐platinum (BMP). All patients received irradiation with megavoltage equipment and 55% of patients received a dose of 5,000 to 6,000 rads in 5–6 weeks time. The tumor was converted to be resectable in ten patients. Nine patients (45%) had the neck and primary tumor completely controlled, while six patients (30%) had partial control. Six of the ten patients who had resection had the tumor controlled at the primary site and neck. The median duration of follow‐up is 12 months (range, 4–32 months). The median survival of the whole group of patients is 12.5 months. A brief review of the current literature is also done in this paper.
Arterial thromboembolic complications of peritoneovenous shunting for malignant ascites
Authors: Paschold E. H. , Jackson Don V. , Albertson D. A. , Woodruff R. D.
Published: February 2007

Peritoneovenous shunting for the treatment of malignant ascites has become increasingly popular. This technique can be complicated by tumor embolization, congestive heart failure, and disseminated intravascular coagulation. Arterial thromboembolism has been encountered in two patients following LeVeen shunt insertion. Recurrent bilateral femoral artery thromboemboli and a cerebrovascular accident occurred in one patient and cerebrovascular thromboembolism developed in a second patient. Major arterial embolization is potentially a serious, although infrequent, complication of peritoneovenous shunting in patients who have malignant ascites.
Substance P in the localization of a carcinoid tumor
Authors: Strodel William E. , Vinik Aaron I. , Jaffe Bernard M. , Eckhauser Frederic E. , Thompson Norman W.
Published: February 2007

A 55‐year‐old woman with an ovarian carcinoid presented with intermittent facial and cervical flushing for 10 years, watery diarrhea for 4 years, and abdominal pain without hepatomegaly. Markedly elevated systemic venous and arterial serotonin levels (830 ng/ml; nl = 50‐200 ng/ml) were found. The highest serotonin levels were observed in the superior venal caval system, but serotonin as a marker for tumor localization was inaccurate and led to an unproductive neck exploration. The histological pattern of this tumor contained purely insular elements. No hepatic or nodal metastases were identified and the lesion was unilateral. Substance P levels were elevated in the venous drainage of the left ovary and in retrospect correctly localized the ovarian tumor. This peptide may prove to be another carcinoid tumor marker in addition to serotonin and 5‐hydroxyindolacetic acid. Substance P may also be an important mediator of symptoms in patients with carcinoid syndrome.
The influence of cryosurgery and electrocoagulation upon metastatic spread
Authors: Zonnevylle J. A. , Zwaveling A.
Published: February 2007

An experiment was performed to investigate the hypothesis that cryosurgery or electrocoagulation of a tumor can have an inhibitory effect upon the metastatic process. Prior investigation had shown that both electrocoagulation and cryosurgery were as effective in causing a local cure of tumor as local excision. An intravenous injection of tumor cells was given a week after local treatment of 10‐day‐old subcutaneous tumors had been administered, and 2 weeks later the number of lung metastases was counted.

No extra beneficial effect of cryosurgery or electrocoagulation upon the metastatic process could be demonstrated, neither with the antigenic tumor system used nor with two nonantigenic systems.
Malignant neoplasm of mixed mesenchymal and neuroepithelial origin (ectomesenchymoma) of thigh
Authors: Shuangshoti Samruay , Kasantikul Vira , Suwangool Pongsepeera , Chittmittrapap Soottiporn
Published: February 2007

A 49‐year‐old man had a malignant soft tissue tumor of the right thigh with metastasis to the femoral region and lower quadrant of the anterior abdominal wall on the right side and the left supraclavicular lymph nodes. The neoplasm showed features of chondrosarcoma and primitive neuroectodermal tumor (combined neuroblastoma, ependymoma, astrocytoma. and oligodendroglioma). The gliomatous part of the mixed tumor was confirmed by identification of the glial fibrillary acidic protein (GFAP). The diverse cellular population suggests a tumor origin from the ectomesenchymal remnant of the neural crest. The mesenchymal component of the neural crest would differentiate into the chondrosarcoma and the neuroectodermal component into the primitive neuroectodermal neoplasm. These various neoplastic elements, then, would form a neoplasm of mixed mesenchymal and neuroepithelial origin or an ectomesenchymoma.
Effect of impaired renal function on tamoxifen
Authors: Sutherland Carl M. , Sternson Larry A. , Muchmore James H. , Ball John E. , Cerise Elmo J.
Published: February 2007

There is no information available in the literature on the blood levels of tamoxifen in patients with decreased renal function. As serious side effects of tamoxifen administered at high doses have been reported, a patient with decreased renal function and metastatic breast cancer was studied to determine the blood levels of tamoxifen while under therapy. Since no abnormally elevated levels of tamoxifen were found in this patient during the month of therapy, results of this study indicate that tamoxifen can be administered to patients with some degree of renal impairment without the risk of giving rise to abnormally elevated blood levels.
Malignant fibrous histiocytoma of the kidney
Authors: Chen Karl T. K.
Published: February 2007

The clinicopathologic features of a rare case of renal malignant fibrous histiocytoma is described and compared with similar cases reported in the literature.
Avidin‐biotin technique is more sensitive than lectin assay for detecting the thomsen friedenreich antigen (T‐antigen) in transitional cell carcinoma of the bladder
Authors: McAlpine Robert G. , Javadpour Nasser , Vafier James A. , Worsham G. F. , O'connell Kevin J.
Published: February 2007

Avidin biotin technique and lectin assay has been compared in a doubleblind study for detection of the T‐antigen in transitional carcinoma of the bladder. Utilizing the tumor registry from the U.S. Naval Hospital in Bethesda, Maryland, patients with transitional cell carcinoma of the bladder were identified. Thirty‐three patients were selected with a total of 43 specimens. Tissues from 26 patients with a total of 43 specimens that showed no lesions and had no known history of genitourinary diseases were used as controls. These tissues were studied for the presence of T‐antigen utilizing avidin biotin or lectin techniques. T‐antigen was detected in 60% of the specimens with lectin technique, while 95% was detected with avidin biotin methods. The T‐antigen was not detected by either method even after the treatment with neuraminidase in six patients. These patients had high grade and high stage tumors. This study demonstrated that normal urothelium has concealed T‐antigen that can be exposed by treating the tissue with neuraminidase. However, the T‐antigen is unconcealed in low grade tumor but disappears in high grade invasive tumor. Avidin biotin technique appears to be a more sensitive method for detecting the presence or absence of the T‐antigen.
Colonization of nonmelanocytic cutaneous lesions by dendritic melanocytic cells: A simulant of acral‐lentiginous (Palmar‐plantar‐subungual‐mucosal) melanoma
Authors: Lambert Muriel W. , Clark Lambert W. , Schwartz Robert A. , Mesa Myra L. , Brodkin Roger H. , Abbey Albert H. , Potter Gene K. , Little R. Walter P.
Published: February 2007

Four cases of colonization of nonmelanocytic lesions by dendritic melanocytic cells are reported, one in a verruca vulgaris of the lip, one in a squamous cell carcinoma in situ of mucous membrane overlying a tonsil, one in a lesion of lichen simplex chronicus with a nevocellular nevus of the external ear, and one in a dermatofibrosarcoma protuberans (Bednar tumor). This is an important biological process of melanocytes that must not be confused with the acral‐lentiginous (palmar‐plantar‐subungual‐mu‐cosal (P‐S‐M) melanoma. It is probably much more common than the paucity of published reports would indicate.
Primary intracranial germinoma with massive ventriculoperitoneal shunt metastases
Authors: Talamo Thomas S. , Mendelow Harvey
Published: February 2007

Ventriculoperitoneal shunt metastases from primary intracranial germinomas are extremely rare. To date, only three case reports of this phenomenon have appeared in the literature. We present the case of a 25‐year‐old black male who developed ventriculoperitoneal shunt metastases 10 months following diagnosis of an intracranial germinoma. Radiotherapy destroyed most of the intracranial tumor, but abdominal metastases became progressive and were not treated with radiotherapy. The role of radiotherapy in the treatment of ventriculoperitoneal shunt metastases is examined and previous cases in the literature are reviewed.
Chondrosarcoma of the head and neck—the value of computed tomography
Authors: Hertzanu Y. , Mendelsohn D. B. , Davidge‐Pitts K. , Cohen M.
Published: February 2007

Chondrosarcomas of the head and neck represent a small percentage and differ in their treatment and prognosis compared with chondrosarcomas elsewhere. Four different cases of chondrosarcoma are presented. One arose intracranially, two in the jaws, one of which followed irradiation for a retinoblastoma, and the last represents chondrosarcomatous transformation in cervical spine Paget disease which is exceptionally rare. Computer tomography (CT) plays an important role in delineating the extent of the tumor with visualization of bony destruction, associated soft‐tissue mass, and calcification, information which is extremely important for surgical and therapeutic planning. CT can be vital in suggesting the best possible site for biopsy which is particularly important in this group of neoplasms where the histological diagnosis may be difficult.
Mitomycin C extravasation ulcers
Authors: Khanna A. K. , Khanna Anuradha , Asthana A. K. , Misra M. K.
Published: February 2007

In a four‐year period, eight patients with mitomycin C extravasation ulcers were encountered. Mitomycin C extravasation produces a painful indolent ulcer that does not have any tendency to heal. If extravasation of the drug is recognized, infusion should be stopped immediately, and the site of infusion should be changed. The ulcers should be excised, and primary closure is recommended; if it is not possible then the defect is covered by a partial thickness skin graft.
An apparent danazol‐induced primary hepatocellular carcinoma: Case report
Authors: Buamah Paul K.
Published: February 2007

This paper presents an apparent case of danazol‐induced primary hepatocellular carcinoma in a 49‐year‐old patient, following two years of continuous therapy with this inhibitor of pituitary gonadotrophin. Discontinuation of the drug failed to cause regression of the tumour.
The significance of metastasis to the bones and soft tissues of the hand
Authors: Morris Don M. , House Homer C.
Published: February 2007

We have treated six patients with cancer metastatic to the hand. All patients died within 6 months after the appearance of hand metastasis. We polled the combined membership of the American Association for Surgery of the Hand and the American Society for Surgery of the Hand to determine their experience with this problem. We also reviewed the pertinent literature concerning this subject. The information obtained from the literature and the poll confirmed our experience. We have managed these patients by amputation, feeling that reconstructive procedures were not indicated if the time necessary to rehabilitate the patient after reconstruction exceeds the patient's life expectancy.
Surgical treatment of concurrent cancer of the esophagus and stomach
Authors: Okudaira Yasuyuki , Sugimachi Keizo , Ueo Hiroaki , Kai Hidenobu , Kuwano Hiroyuki , Inokuchi Kiyoshi
Published: February 2007

Out of a total of 250 resections for carcinoma of the esophagus done in our department between 1965 and 1983, there were 11 patients with a concurrent esophageal cancer, nine being gastric cancer and seven of them early gastric cancer. In these nine, four underwent resection of the esophagus and lesser curvature of the stomach with gastric tube reconstruction. Two of the four patients are alive 10 and 3 yr postoperatively. We hold the view that detailed preoperative gastric examination is most important to plan the surgical repair and that the small gastric tube may serve as a substitute by resecting the lesser curvature of the stomach in cases of early proximal gastric cancer.
Hemangiosarcoma complicating paget's disease of the bone
Authors: Chen KARL T. K.
Published: February 2007

An 87‐year‐old man with Paget's disease of the left humerus was found to have a Paget's sarcoma upon pathologic examination of the left upper limb, which was disarticulated for severe pain and recurrent fractures. The histologic type of this tumor, a hemangiosarcoma, was unique among Paget's sarcomas.
Cancer of the head of the pancreas: An institutional review with emphasis on surgical therapy
Authors: Rosenberg Joel M. , Welch John P. , Macaulay William P.
Published: February 2007

A clinical review of 461 patients with adenocarcinoma of the pancreas is presented. Seventy‐nine percent of the group underwent laparotomy, including laparotomy and biopsy (n = 134), bypass procedures (n = 207), and radical resection (n = 24). The operative mortality following chole‐cystoenterostomy or choledochoenterostomy was similar but survival was greater following the latter procedure. Thirteen percent having biliary bypass alone needed later gastric bypass. Radical resection is recommended under favorable conditions (6.6% in this series). The five‐year survival in this group was 12.5% and the operative mortality was 9% over the last 10 years.
Tissue CEA detection by immunoperoxidase (PAP) test in colorectal polyps: Correlations with the degree of dysplasia
Authors: Amanti C. , Midiri C. , Benedetti M. , Campisi C. , Di Tondo U. , Castagna C. , Peronace L. , Santeusanio G. , Dl Paola M.
Published: February 2007

We study the presence of Carcinoembryonic antigen (CEA) on 39 colorectal polyps by the immunoperoxidase technique. The histological examination demonstrated 15 tubular adenomas, one villous adenoma, two tubulo‐villous adenomas, six tubular adenomas with slight dysplasia, one tubular adenoma with moderate dysplasia, four tubular adenomas with severe dysplasia, three tubulo‐villous adenomas with severe dysplasia, five tubular adenomas with neoplastic degeneration, and two tubulo‐villous adenomas with neoplastic degeneration. Twenty‐eight of thirty‐nine polyps (71.79%) showed a positive staining reaction for CEA. Regarding the intensity of the reaction (classified as absent or negative [ ‐], slightly positive [ + ], and markedly positive [++]), 11/39 polyps presented a negative reaction (28.21%), 19/39 (48.71%) presented a slight reaction, and 10/39 polyps (25.64%) presented a marked reaction.

Results demonstrated a higher intensity of the staining reaction in severely displastic polyps and in neoplastic degeneration. In conclusion, it is possible that the presence of CEA can be useful to show an initial cellular restlessness of certain polyps.
Adjuvant chemotherapy of gastric carcinoma: A pilot study of oral administration of injectable 5‐fluorouracil
Authors: Wu Yong‐Fang
Published: February 2007

During the past three years we have entered 54 patients with gastric adenocarcinoma into a clinical trial of oral administration of injectable 5‐fluorouracil (5‐Fu). Of the 20 unresectable advanced cases, the median survival was 6.2 months, and for 34 resectable ones, median survival was 22 months. These results were comparable to those reported in the literature. It is also safe, easy to administer, well tolerated, and does not have any apparent side effects. The author discovered for the first time that oral administration of 5‐Fu could improve the liver function as manifested by a marked decrease of serum GPT level in advanced gastric cancer.
Human renal carcinoma: Characterization of five new cell lines
Authors: Barton Grossman H. , Wedemeyer Gary , Ren Liqin
Published: February 2007

Five human renal carcinoma cell lines have been established in long‐term tissue culture. Two of the cell lines, UM‐RC‐2 and UM‐RC‐3, produced clear cell tumors in athymic nude mice. The cell lines have been characterized by staining with oil red O, doubling time in vitro, and number of chromosomes. Although protein A assay reactivity of autologous combinations of patient's sera and tumor cells were seen with all five cell lines, similar binding was also found with autologous normal kidney cultures. However, the immune adherence assay demonstrated low titer autologous reactivity with two renal carcinoma cell lines but not with the corresponding normal kidney cultures. This strongly suggests host recognition of tumor‐associated antigens. Characterization of cell surface antigens with murine monoclonal antibodies demonstrated shared reactivity between normal kidney tubular cells and renal carcinoma cells. Antibody A68.ll reacted strongly with all five cell lines. Antibody A80 bound to only UM‐RC‐3 and UM‐RC‐6.
Metastasis in the androgen‐lnsensitive Nb rat prostatic carcinoma system
Authors: Drago Joseph R. , Lombard Jeffrey S.
Published: February 2007

This unit has in the past evaluated the Nb rat prostatic adenocarcinoma model with respect to chemotherapies. Recently, this unit has been evaluating agents that may have a role in decreasing metastatic rate. The three androgen‐insensitive tumors, Nb Pr A.I. I, II, III, have been evaluated herein. Agents that have been used include indomethocin, heparin, heparin plus cortisone, and heparan sulfate (SP54). It has been shown that these agents do play a role in reducing the metastasis. In evaluation of Nb Pr A.I, I, control animals had a metastatic rate of 57%. In treatment with indocin, only 21% of the animals, three of 14 animals treated, had a metastasis, and treatment with heparin and cortisone resulted in one of 14 animals having metastasis. Similar observations were seen when treatment with SP54 and heparin was evaluated in the Nb Pr A.I. III; 18 and 27% of treatment group animals had metastasis, whereas 55% of control groups had metastasis. Similarly, in the Nb Pr A.I. II evaluation, control animals having a metastatic rate of 43 % had heparin plus cortisone and heparin alone, and this particular tumor model revealed complete resolution with no animals having metastatic disease. The majority of these agents have not effected tumor volume in terms of reduction as much as the best chemotherapeutic agents in this model system include cyclophosphamide and cis‐platinum.
Nb rat prostate adenocarcinoma model: Evaluation of the subrenal capsular assay system
Authors: Drago Joseph R. , Lombard Jeff
Published: February 2007

During the course of the last 6 years, this laboratory unit has evaluated the Nb rat prostate adenocarcinoma model with respect to various chemotherapies. Heretofore, tumors were treated after they had been implanted in the subcutaneous space. The most active chemotherapeutic agents have been cyclophosphamide, adriamycin, and cis‐platinum. Herein, we report our initial experience utilizing the subrenal capsular assay. The advantage of this system is that one is able to determine the effect of chemotherapy in a very short period of time, ie, 7 days. This may be a method to save considerable expense and may serve as a useful predictor for potential future chemotherapeutic trials. In our assay systems, cyclophosphamide, adriamycin, cis‐platinum, and methotrexate did result in a significant decrease in the change in tumor volume. This change paralleled the results that we have seen in the past with the use of chemotherapy of the subcutaneous tumor nodules. Further exploration of this method is warranted from a time efficiency standpoint as well as a cost standpoint.
Malignant fibrous histiocytoma of solitary jejunal diverticulum
Authors: Singh C. , Gupta S. , Gupta S.
Published: February 2007

A rare case of malignant fibrous histiocytoma arising from a solitary jejunal diverticulum leading to its perforation is described in a 37‐year‐old male. The patient presented with peritonitis and on exploration revealed perforation of a jejunal diverticulum containing a soft, friable mass. Biopsy from the mass revealed a malignant fibrous histiocytoma. This appears to be the first description in literature of a malignant fibrous histiocytoma with that particular localization.
Paget's disease of the anal mucosa in association with carcinoma demonstrating mucoepidermoid features
Authors: Giltman Larry I. , Osborne Pamela T. , Coleman Sidney A. , Uthman Edward O.
Published: February 2007

A case of Paget's disease of the anal mucosa with an underlying carcinoma demonstrating mucoepidermoid features is reported. The histopathologic characteristics of both extramammary Paget's disease and mucoepidermoid carcinoma are noted. Special histochemical staining procedures were consistent with the diagnosis. The actual histogenesis of extramammary Paget's disease and mucoepidermoid carcinomas are controversial topics that are briefly discussed in this paper.
Giant intraductal papilloma of the breast: A case report
Authors: Roy I. , Meakins J. L. , Tremblay G.
Published: February 2007

A case of an unusually large solitary intraductal papilloma of the breast is reported. This benign neoplasm presented as a 15‐cm breast mass, enlarging over a 2‐year period. The case illustrates that benign intraductal papilloma may rarely present as a large breast mass and therefore should be considered in the differential diagnosis of very large breast lesions.
Adult respiratory distress syndrome in a pregnant patient with a pheochromocytoma
Authors: Feldman Jerome M.
Published: February 2007

Five weeks after developing spells of shortness of breath, headache, weakness and abdominal pain, a 29‐year‐old woman, who was in the 36th week of her third pregnancy developed adult respiratory distress syndrome (ARDS). Although the ARDS resolved after a cesarean section, her infant died at birth. Her “spells” continued until a left pheochromocytoma was diagnosed and resected 2 years later. If there are no other known inciting causes of ARDS in a pregnant patient, a pheochromocytoma should be ruled out with appropriate catecholamine determinations.
Systemic scleroderma and small cell carcinoma of the lung
Authors: Sarma Deba P. , Weilbaecher Thomas G.
Published: February 2007

A 64‐year‐old man diagnosed to have systemic scleroderma for 1 year developed small‐cell carcinoma of the lung. Six additional cases obtained from the literature describing small‐cell carcinoma occurring in patients with scleroderma are reviewed.
Effectiveness of scalene node biopsy for staging of lung cancer in the absence of palpable adenopathy
Authors: Bernstein Michael P. , Ferrara John J. , Brown Louis
Published: February 2007

Scalene node biopsy (SNB) has been performed in patients with lung cancer at the Saint Francis Hospital and Medical Center if any of the following criteria has been present: (1) potentially resectable central lesion by chest radiograph, or (2) significant cardiac or pulmonary dysfunction, thereby placing the patient at increased risk for thoracotomy, or (3) a diagnosis of adenocarcinoma prior to SNB. Within these guidelines, a retrospective study was undertaken to determine the benefit of routine SNB in the absence of clinically palpable scalene nodes.

In a 2‐year period beginning April 1981, 56 patients (37 males) presented with radiographic evidence of lung carcinoma without clinical evidence of scalene adenopathy. Approximately half of the lesions were of a central position. While the majority had symptoms of cough, hemoptysis, or chest pain, the primary lung lesion was identified on routine chest radiograph in 15 (27%). In only three was there no history of smoking, the remainder having at least a 20‐pack‐year history of cigarette use.

Following a routine evaluation, 57 SNBs were performed alone or in concert with other surgical procedures (mediastinoscopy, bronchoscopy). Of these, only two (3.5%) were diagnostic and indicative of unresectable disease. While in one patient no additional procedure was performed, a simultaneous Chamberlain procedure in the other confirmed that the patient was unresectable for cure. In the remaining patients, tissue diagnosis of cancer was obtained through other maneuvers.

Because of the low probability that SNB in the absence of clinically palpable nodes altered the management of lung cancer, we do not believe it to be of benefit in the diagnosis or staging of this disease.
An assessment of the risk of developing hyperparathyroidism and thyroid disorders subsequent to neck irradiation in middle‐aged women
Authors: Hedman Ingmar , Fjälling Martha , Lindberg Sture , Lundberg Lena‐Marie , Tisell Lars‐Erik
Published: February 2007

We investigated the occurrence of thyroid and parathyroid disorders in 100 women (age 66–70 years) irradiated for cervical spondylosis on average 25 years previously and in 100 control women of similar age. Hyperparathyroidism (HPT), proven by operation, was diagnosed in one patient of each group, and three additional cases were diagnosed biochemically among irradiated women. The difference in incidence is not significant. Nor was there any significant difference in incidence of thyroid disorders. No thyroid carcinoma was found in either group. Even if there is a moderate increase of HPT after neck irradiation in middle‐aged women the risk is not so great as to warrant organised follow‐up.
Intestinal polyposis and periampullary carcinoma—changing concepts
Authors: Guyton Daniel P. , Schreiber Helmut
Published: February 2007

Adenomatous polyps lead directly to carcinoma of the colon in patients with one of the familial syndromes of intestinal polyposis. Elective colectomy is prophylactic and life‐saving. A subgroup of patients will develop periampullary carcinoma, again arising from the presence of adenomatous polyps. Such a case is presented. These polyps should be surgically excised to ensure adequate pathologic examination. Yearly upper endos‐copic examination is an essential element of management. Either the presence of carcinoma in situ or the recurrence of these polyps following excision is confirmation of behavior with a high propensity for the devleopment of invasive cancer and requires aggressive treatment.
Plasma proteins as indices of response to nutritional therapy in cancer patients
Authors: Ota David M. , Frasier Pamela , Guevara Juan , Foulkes Mary
Published: February 2007

The use of plasma albumin (ALB), transferrin (TFN), prealbumin (TBPA), retinol‐binding protein (RBP), triceps skin fold (TSF), and midarm muscle circumference (MAMC) as determinants of response to nutritional therapy (TPN) was investigated in 40 cancer patients during preoperative TPN. Thirty‐one patients received 90% or more of their anabolic caloric requirement (Harris‐Benedict equation) by means of TPN. During this study period (average 11.1 ± 4.7 days) nutritional assessments were completed before TPN and on the last day of TPN before surgery. Average weight loss based on usual body wt (UBW) and ideal body wt (IBW) was 19 ± 11% and 9 ± 15%, respectively (not significant, NS). Weight loss (UBW) correlated with ALB (P < 0.001), TBPA (P < 0.005) and RBP (P < 0.02) but did not correlate with TFN (P < 0.06), TSF, and MAMC. Weight loss (IBW) correlated with TSF (P < 0.01) and MAMC (P < 0.03) but did not correlate with plasma protein (PP). During TPN the average percent increases for PP were 0.1% (ALB, NS), 20% (TFN, NS), 60% (TBPA, P < 0.02), and 116% (RBP, P < 0.005). These results suggest that plasma TBPA and RBP are significant parameters of response to short‐term nutritional therapy in cancer patients.
Untreated colorectal cancer in a community hospital
Authors: Johnson Houston
Published: February 2007

The tumor registry of a community hospital has been reviewed, and 60 patients with untreated colon and rectal cancer have been identified. Thirty‐four patients were black and 26 patients were white. Sixty‐five percent of black patients had specified colonic lesions primarily distributed in the right colon and proximal to the splenic flexure. Sixty‐three percent of white patients had specified lesions localized to the sigmoid colon. The patients had disease in local, regional, and disseminated stages, and lethality was associated with all stages. Forty‐eight percent of patients expired in less than 30 days after presenting to the hospital, and two‐thirds expired between 1 and 2 months of presentation. Only two patients survived more than 1 year. These data suggest that untreated colorectal cancer will be nearly uniformly fatal early in all patients who go untreated.
Lymphocyte populations with abnormal kappa:lambda ratios in reactive lymphoid hyperplasia
Authors: Bain Vincent G. , Bain Gordon O.
Published: February 2007

The lymph node biopsies of 12 patients with lymphadenopathy due to reactive hyperplasia contained lymphocyte populations with increased percentages of B‐cells and abnormal numbers of cells with single class surface immunoglobulins. Ten patients were followed for periods of 3–30 months: one developed a non‐Hodgkin's lymphoma and one Hodgkin's disease. One other has persisting lymph node enlargement. Two patients had nonlymphoid malignancies. The other six remain well without lymphadenopathy. Twenty‐five of 40 patients with reactive lymph node hyperplasia and normal kappa/lambda ratios followed for 9–36 months had a similar incidence of lymphoid malignancy and persistent lymph node enlargement. The follow‐up data so far available do not support a hypothesis that reactive lymphoid hyperplasia with increased numbers of cells with single class surface immunoglobulin is associated with higher morbidity than reactive hyperplasia containing the usual polytypic lymphocyte populations.
Breast carcinoma metastatic to eyelids: Case report and review of the literature
Authors: Dabski Krzysztof , Milgrom Halina , Stoll Howard L.
Published: February 2007

Violaceous, indurated plaques around both eyes were found to be cutaneous metastases and the initial clinical presentation of a lobular carcinoma of the breast in an 80‐year‐old woman. Available literature indicates that breast carcinoma is the most common metastatic tumor of the eyelid and the onset of a palpebral mass may precede the diagnosis of the primary tumor in the breast.
Pathological evaluation of hepatic dearterialization in encapsulated hepatocellular carcinoma
Authors: Tanaka Nobutaka , Okamoto Eizo , Toyosaka Akihiro , Fujiwara Shiro
Published: February 2007

Specimens of encapsulated hepatocellular carcinoma from 48 patients who had received no previous treatment and from six patients previously treated by hepatic arterial interruption by embolization or ligation were obtained by resection and examined for incidence and extent of necrosis of the tumor. Among the 48 specimens from the non‐pre‐treated patients, 25 tumors were smaller than 5 cm and showed no notable necrosis; of the 23 remaining tumors—which were larger than 5 cm—12 (52%) showed spontaneous central necrosis. The necrosis rate of the tumor ranged from 10% to 40%. In contrast, in six specimens from pretreated cases, more than 60% of the tumors were found to be necrotic. Two tumors smaller than 5 cm were completely necrotized by embolization. The findings indicated the significance of hepatic dearterialization for the management of encapsulated hepatocellular carcinoma. Daughter nodules, however, were found to have escaped necrosis.
Detection of ABO(H) blood group antigens: A study in tissue culture
Authors: Feinmesser R. , Gay I. , Brama I.
Published: February 2007

The association between malignant tranformation and the loss of ABO(H) blood group antigens was documented by several authors. Most of the work was done on paraffin sections, though a small portion was performed on fresh frozen tissues. We suggest that the specific red cell adherance (SRCA) test can be applied to tissues cultivated in tissue culture for determination of malignant transformation. This study supports this assumption.
Management of cardiac tamponade in patients with malignancy
Authors: Reitknecht Felice , Regal Anne‐Marie , Antkowiak Joseph G. , Takita Hiroshi
Published: February 2007

From January 1967 through November 1983, 66 patients with a previously established diagnosis of malignancy were treated for pericardial effusion by the creation of a pericardial window. The majority of the patients had malignancies of the breast or lung, or lymphoma. There were no deaths or major complications attributable to the operative procedures.

The presence of malignant pericardial effusion is usually evidence of far‐advanced disease and, therefore, the prognosis is poor. Seventeen patients (26%) were alive 1 or more years postoperatively and 33 patients (50%) died within 3 months of operation. Despite the grave prognosis, it is still our belief that malignant pericardial effusion should be treated aggressively by open surgical drainage so that continuation of therapy for the primary malignancy would be possible.
In vitro antibiotic activity of 11 beta‐lactam antibiotics in a cancer center
Authors: Landoy Zvi , Rotstein Coleman , Surgalla Michael J. , Botzer Robert , Fitzpatrick John E. , Blumenson Leslie E.
Published: February 2007

Two‐thousand, five‐hundred and twenty‐four bacterial isolates were tested against 11 new beta‐lactam antibiotics in a prospective study conducted in a cancer center. E. coli, P. aeruginosa, and K. pneumoniae were the most common gram‐negative organisms isolated, while S. aureus and Entero‐cocccus were the most common organisms among the gram‐positive. The new cephalosporins were more active than the semisynthetic penicillins against E. coli, P. aeruginosa, and K. pneumoniae (p<0.001). Mezlocillin had better activity than the other semisynthetic penicillins against most of the gram‐negative organisms as well as the enterococci. As a result, mezlocillin was preferred as a beta‐lactam agent to be employed with an aminoglycoside as empiric antibiotics for febrile patients with neoplasia.
Clinical uses of prosthetic devices in brachiotherapy for oral cavity tumors
Authors: Sela M. , Weshler Z. , Loewental E. , Taicher S.
Published: February 2007

Three different acrylic resin intraoral stents used for radiotherapy are described. They serve multiple functions in the treatment of tumors of the oral cavity. They are prepared individually and are necessary for accurate treatment planning and in order to minimize the exposure of hospital personnel to radiation.
The simultaneous coexistence of adenocarcinoma and primary malignant lymphoma in the stomach
Authors: Czerniak Abraham , Lotan Gad , Engelberg Isaac S. , Rabau Micha Y. , Avigad Itamar , Schachter Pinhas , Wolfstein Isidor
Published: February 2007

A case of simultaneous adenocarcinoma and primary malignant lymphoma as two independent growths of the stomach is presented. Review of the literature documented two such cases along with nine cases of the collision‐tumor type. The differential criteria between this entity and collision tumor and carcinosarcoma are emphasized. Diagnosis and treatment is discussed.