bluuebunny/crossref_metadata_2025 huggingface dataset:
Potential causal association between aspirin use and the reduced risk of hayfever or allergic rhinitis: a Mendelian randomization study
Authors: Li Li , Zhang Yuanding , Liu Xiangliang , Li Junxin , Yang Qiuyu , Jiang Jiajia , Liu Hong , Fu Zhongying , Chen Weilun
Published: August 2023

Background

The evidence from observational studies on the association between the use of aspirin and the risk of hayfever or allergic rhinitis is conflicting, with a dearth of high-quality randomized controlled trials.

Objective

This study aims to investigate the causal relationship between aspirin use and the risk of hayfever or allergic rhinitis.

Methods

We conducted a two-sample Mendelian randomization (MR) analysis using the inverse-variance weighted (IVW), weighted median, and MR-Egger regression methods. We utilized publicly available summary statistics datasets from genome-wide association studies (GWAS) meta-analyses on aspirin use in individuals of European descent (n = 337,159) as the exposure variable, and a GWAS on doctor-diagnosed hayfever or allergic rhinitis in individuals from the UK Biobank (n = 83,529) as the outcome variable.

Results

We identified 7 single nucleotide polymorphisms (SNPs) at genome-wide significance from the GWASs associated with aspirin use as instrumental variables (P<5×10−8; linkage disequilibrium r2 <0.1). The IVW method provided evidence supporting a causal association between aspirin use and reduced risk of hayfever or allergic rhinitis (β = -0.349, SE = 0.1356, P = 0.01008). MR-Egger regression indicated no causal association between aspirin use and hayfever or allergic rhinitis (β = -0.3742, SE = 0.3809, P = 0.371), but the weighted median approach yielded evidence of a causal association (β = -0.4155, SE = 0.1657, P = 0.01216). Cochran’s Q test and the funnel plot indicated no evidence of heterogeneity and asymmetry, indicating no directional pleiotropy.

Conclusion

The findings of the MR analysis support a potential causal relationship between aspirin use and the reduced risk of hayfever or allergic rhinitis.
Association between peri-implantitis and systemic inflammation: a systematic review
Authors: Yan Yumeng , Orlandi Marco , Suvan Jeanie , Harden Simon , Smith Jacqueline , D’Aiuto Francesco
Published: August 2023

Background

Peri-implantitis is an infectious/inflammatory disease with similar clinical and radiographic features to periodontitis. Overwhelming evidence confirmed that periodontitis causes elevations in systemic inflammatory mediators; this is unclear for peri-implantitis. Hence, this study aimed to appraise all available evidence linking peri-implantitis with systemic inflammation.

Methods

A systematic review was completed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Eight electronic databases (Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, Web of Science, Dentistry & Oral Sciences Source, Scopus, LILACS, and China Online), ClinicalTrials.gov, WHO International Clinical Trials Registry Platform (ICTRP), and gray literature were searched up to February 9, 2023. Human studies of randomized controlled trials, non-randomized intervention studies, cohort studies, case–control, and cross-sectional studies were eligible for inclusion. Quantitative analyses were performed using random effects models.

Results

A total of 27 full-text articles were retrieved, and 11 clinical studies were included in the final analyses. All evidence gathered demonstrated a consistent association between peri-implantitis and systemic inflammation. Patients with peri-implantitis exhibited higher levels of serum C-reactive protein (CRP) (standard mean difference (SMD): 4.68, 98.7% CI: 2.12 to 7.25), interleukin-6 (IL-6) (weighted mean difference (WMD): 6.27 pg/mL, 0% CI: 5.01 to 7.54), and white blood cell counts (WMD: 1.16 * 103/μL, 0% CI: 0.61 to 1.70) when compared to participants without peri-implantitis.

Conclusion

Peri-implantitis is associated with higher systemic inflammation as assessed by serum CRP, IL-6, and white blood cell counts. Further research is needed to clarify the nature of this association.

Systematic review registration

https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=246837, identifier CRD42021246837.
CEACAM expression in an in-vitro prostatitis model
Authors: Kube-Golovin Irina , Lyndin Mykola , Wiesehöfer Marc , Wennemuth Gunther
Published: August 2023

Background

Prostatitis is an inflammatory disease of the prostate gland, which affects 2-16% of men worldwide and thought to be a cause for prostate cancer (PCa) development. Carcinoembryogenic antigen-related cell adhesion molecules (CEACAMs) are deregulated in inflammation and in PCa. The role of CEACAMs in prostate inflammation and their possible contribution to the malignant transformation of prostate epithelial cells is still elusive. In this study, we investigated the expression of CEACAMs in an in-vitro prostatitis model and their potential role in malignant transformation of prostate epithelial cells.

Methods

Normal prostate epithelial RWPE-1 cells were treated with pro-inflammatory cytokines to achieve an inflammatory state of the cells. The expression of CEACAMs and their related isoforms were analyzed. Additionally, the expression levels of selected CEACAMs were correlated with the expression of malignancy markers and the migratory properties of the cells.

Results

This study demonstrates that the pro-inflammatory cytokines, tumor necrosis factor alpha (TNFα) and interferon-gamma (IFNγ), induce synergistically an up-regulation of CEACAM1 expression in RWPE-1 cells, specifically favoring the CEACAM1-L isoform. Furthermore, overexpressed CEACAM1-L is associated with the deregulated expression of JAK/STAT, NFκB, and epithelial-mesenchymal transition (EMT) genes, as well as an increased cell migration.

Conclusion

We postulate that CEACAM1 isoform CEACAM1-4L may synergistically contribute to inflammation-induced oncogenesis in the prostate.
Vaccine-induced neutralizing antibody responses to seasonal influenza virus H1N1 strains are not enhanced during subsequent pandemic H1N1 infection
Authors: Mooij Petra , Mortier Daniella , Aartse Aafke , Murad Alexandre B. , Correia Ricardo , Roldão António , Alves Paula M. , Fagrouch Zahra , Eggink Dirk , Stockhofe Norbert , Engelhardt Othmar G. , Verschoor Ernst J. , van Gils Marit J. , Bogers Willy M. , Carrondo Manuel J. T. , Remarque Edmond J. , Koopman Gerrit
Published: August 2023

The first exposure to influenza is presumed to shape the B-cell antibody repertoire, leading to preferential enhancement of the initially formed responses during subsequent exposure to viral variants. Here, we investigated whether this principle remains applicable when there are large genetic and antigenic differences between primary and secondary influenza virus antigens. Because humans usually have a complex history of influenza virus exposure, we conducted this investigation in influenza-naive cynomolgus macaques. Two groups of six macaques were immunized four times with influenza virus-like particles (VLPs) displaying either one (monovalent) or five (pentavalent) different hemagglutinin (HA) antigens derived from seasonal H1N1 (H1N1) strains. Four weeks after the final immunization, animals were challenged with pandemic H1N1 (H1N1pdm09). Although immunization resulted in robust virus-neutralizing responses to all VLP-based vaccine strains, there were no cross-neutralization responses to H1N1pdm09, and all animals became infected. No reductions in viral load in the nose or throat were detected in either vaccine group. After infection, strong virus-neutralizing responses to H1N1pdm09 were induced. However, there were no increases in virus-neutralizing titers against four of the five H1N1 vaccine strains; and only a mild increase was observed in virus-neutralizing titer against the influenza A/Texas/36/91 vaccine strain. After H1N1pdm09 infection, both vaccine groups showed higher virus-neutralizing titers against two H1N1 strains of intermediate antigenic distance between the H1N1 vaccine strains and H1N1pdm09, compared with the naive control group. Furthermore, both vaccine groups had higher HA-stem antibodies early after infection than the control group. In conclusion, immunization with VLPs displaying HA from antigenically distinct H1N1 variants increased the breadth of the immune response during subsequent H1N1pdm09 challenge, although this phenomenon was limited to intermediate antigenic variants.
Who lives in a pear tree under the sea? A first look at tree reefs as a complex natural biodegradable structure to enhance biodiversity in marine systems
Authors: Dickson Jon , Franken Oscar , Watson Maryann S. , Monnich Bob , Holthuijsen Sander , Eriksson Britas Klemens , Govers Laura L. , van der Heide Tjisse , Bouma Tjeerd J.
Published: August 2023

Hard substrates play an important role in global marine systems as settlement surface for sessile reef-forming species such as corals, seaweeds, and shellfish. In soft-sediment systems, natural hard substrates such as stones, bedrock and driftwood are essential as they support diverse assemblages of reef-associated species. However, availability of these hard substrates has been declining in many estuaries and shallow seas worldwide due to human impacts. This is also the case in the Dutch Wadden Sea, where natural hard substrates have gradually disappeared due to burial by sand and/or active removal by humans. In addition, driftwood that was historically imported from rivers has been nullified by upstream logging and coastal damming of estuaries. To investigate the historic ecological role of wood presence in the Wadden Sea as settlement substrate and fish habitat, we constructed three meter high artificial reefs made of felled pear trees. Results demonstrate that these reefs rapidly developed into hotspots of biodiversity. Within six months, the tree-reefs were colonized by sessile hard substrate associated species, with a clear vertical zonation of the settled species. Macroalgae and barnacles were more abundant on the lower parts of the reef, while bryozoans were more dominant on the upper branches. In addition, six fish species were observed on the reefs, while only two species were caught on sandy control sites. Moreover, the abundance of fish on the reefs was five times higher. Individuals of the most commonly caught species, the five-bearded rockling Ciliata mustela, were also larger on the reef. These patterns also hold true for common prawn, Palaemon serratus, which were also larger and ten times more numerous on the reefs. Present findings indicate that the reintroduction of tree-reefs as biodegradable, structurally complex hard substrates can increase local marine biodiversity in soft-sediment systems within relatively short time scales.
Opportunities in optical and electrical single-cell technologies to study microbial ecosystems
Authors: Mermans Fabian , Mattelin Valérie , Van den Eeckhoudt Ruben , García-Timermans Cristina , Van Landuyt Josefien , Guo Yuting , Taurino Irene , Tavernier Filip , Kraft Michael , Khan Hira , Boon Nico
Published: August 2023

New techniques are revolutionizing single-cell research, allowing us to study microbes at unprecedented scales and in unparalleled depth. This review highlights the state-of-the-art technologies in single-cell analysis in microbial ecology applications, with particular attention to both optical tools, i.e., specialized use of flow cytometry and Raman spectroscopy and emerging electrical techniques. The objectives of this review include showcasing the diversity of single-cell optical approaches for studying microbiological phenomena, highlighting successful applications in understanding microbial systems, discussing emerging techniques, and encouraging the combination of established and novel approaches to address research questions. The review aims to answer key questions such as how single-cell approaches have advanced our understanding of individual and interacting cells, how they have been used to study uncultured microbes, which new analysis tools will become widespread, and how they contribute to our knowledge of ecological interactions.
Changes in antioxidant status and DNA repair capacity are corroborated with molecular alterations in malignant thyroid tissue of patients with papillary thyroid cancer
Authors: Eng Zing Hong , Abdul Aziz Azlina , Ng Khoon Leong , Mat Junit Sarni
Published: August 2023

Introduction: Papillary thyroid cancer (PTC) accounts for approximately 80% of all thyroid cancer cases. The mechanism of PTC tumourigenesis is not fully understood, but oxidative imbalance is thought to play a role. To gain further insight, this study evaluated antioxidant status, DNA repair capacity and genetic alterations in individuals diagnosed with benign thyroid lesion in one lobe (BTG) and PTC lesion in another.

Methods: Individuals with coexisting BTG and PTC lesions in their thyroid lobes were included in this study. Reactive oxygen species (ROS) level, ABTS radical scavenging activity, ferric reducing antioxidant capacity, glutathione peroxidase and superoxide dismutase activities were measured in the thyroid tissue lysate. The expression of selected genes and proteins associated with oxidative stress defence and DNA repair were analysed through quantitative real-time PCR and Western blotting. Molecular alterations in genomic DNA were analysed through whole-exome sequencing and the potentially pathogenic driver genes filtered through Cancer-Related Analysis of Variants Toolkit (CRAVAT) analysis were subjected to pathway enrichment analysis using Metascape.

Results: Significantly higher ROS level was detected in the PTC compared to the BTG lesions. The PTC lesions had significantly higher expression of GPX1, SOD2 and OGG1 but significantly lower expression of CAT and PRDX1 genes than the BTG lesions. Pathway enrichment analysis identified “regulation of MAPK cascade,” “positive regulation of ERK1 and ERK2 cascade” and “negative regulation of reactive oxygen species metabolic process” to be significantly enriched in the PTC lesions only. Four pathogenic genetic variants were identified in the PTC lesions; BRAFV600E, MAP2K7-rs2145142862, BCR-rs372013175 and CD24 NM_001291737.1:p.Gln23fs while MAP3K9 and G6PD were among 11 genes that were mutated in both BTG and PTC lesions.

Conclusion: Our findings provided further insight into the connection between oxidative stress, DNA damage, and genetic changes associated with BTG-to-PTC transformation. The increased oxidative DNA damage due to the heightened ROS levels could have heralded the BTG-to-PTC transformation, potentially through mutations in the genes involved in the MAPK signalling pathway and stress-activated MAPK/JNK cascade. Further in-vitro functional analyses and studies involving a larger sample size would need to be carried out to validate the findings from this pilot study.
Investigation of the efficacy of low-frequency repetitive transcranial magnetic stimulation on upper-limb motor recovery in subacute ischemic stroke without cortical involvement: a protocol paper for a multi-center, double-blind randomized controlled trial
Authors: Cho Hee-Mun , Cha Seungwoo , Sohn Min Kyun , Jee Sungju , Chang Won Kee , Kim Won-Seok , Paik Nam-Jong
Published: August 2023

Introduction

The incidence of stroke is increasing steadily due to factors such as population aging. Approximately 80% of stroke survivors have motor disorders affecting their daily lives. Repetitive transcranial magnetic stimulation (rTMS) has been reported to maximize functional recovery after stroke along with exercise intervention in upper limb rehabilitation treatment. However, whether rTMS affects the recovery of upper limb function in patients with stroke remains unclear. Therefore, in this trial, we will investigate the efficacy of low-frequency rTMS in patients with subcortical and brainstem ischemic stroke.

Methods

This study has been designed as a multi-center, double-blind, randomized controlled trial to compare the efficacy of low-frequency rTMS over the contralesional M1 with sham stimulation. Overall, 88 participants will be allocated to the intervention or control group in a 1:1 ratio, with stratification according to their initial upper extremity Fugl-Meyer assessment (UE-FMA) score. The participants will receive either 30 min of real rTMS (intervention group) or sham rTMS (control group), followed by 30 min of occupational therapy for 10 consecutive workdays. All the participants will receive the same amount of rehabilitation therapy throughout the intervention period. Evaluations will be performed at baseline (T0), at the end of treatment (T1), and 4 weeks after the end of treatment (T2), including the box and block test (BBT), UE-FMA, Korean version of the Modified Barthel Index, and NIH Stroke Scale scores, Finger tapping test, Brunnstrom stage, modified Ashworth scale, and grip strength. The primary outcome will be the change in the BBT score between T0 and T2.

Conclusion

This study will provide evidence on the efficacy of low-frequency rTMS in motor function recovery of the upper limb in patients with subacute, subcortical, and brainstem ischemic stroke.

Clinical trial registration

ClinicalTrials.gov, identifier [NCT05535504].
Fiber-orientation independent component of R2* obtained from single-orientation MRI measurements in simulations and a post-mortem human optic chiasm
Authors: Fritz Francisco J. , Mordhorst Laurin , Ashtarayeh Mohammad , Periquito Joao , Pohlmann Andreas , Morawski Markus , Jaeger Carsten , Niendorf Thoralf , Pine Kerrin J. , Callaghan Martina F. , Weiskopf Nikolaus , Mohammadi Siawoosh
Published: August 2023

The effective transverse relaxation rate (R2*) is sensitive to the microstructure of the human brain like the g-ratio which characterises the relative myelination of axons. However, the fibre-orientation dependence of R2* degrades its reproducibility and any microstructural derivative measure. To estimate its orientation-independent part (R2,iso*) from single multi-echo gradient-recalled-echo (meGRE) measurements at arbitrary orientations, a second-order polynomial in time model (hereafter M2) can be used. Its linear time-dependent parameter, β1, can be biophysically related to R2,iso* when neglecting the myelin water (MW) signal in the hollow cylinder fibre model (HCFM). Here, we examined the performance of M2 using experimental and simulated data with variable g-ratio and fibre dispersion. We found that the fitted β1 can estimate R2,iso* using meGRE with long maximum-echo time (TEmax ≈ 54 ms), but not accurately captures its microscopic dependence on the g-ratio (error 84%). We proposed a new heuristic expression for β1 that reduced the error to 12% for ex vivo compartmental R2 values. Using the new expression, we could estimate an MW fraction of 0.14 for fibres with negligible dispersion in a fixed human optic chiasm for the ex vivo compartmental R2 values but not for the in vivo values. M2 and the HCFM-based simulations failed to explain the measured R2*-orientation-dependence around the magic angle for a typical in vivo meGRE protocol (with TEmax ≈ 18 ms). In conclusion, further validation and the development of movement-robust in vivo meGRE protocols with TEmax ≈ 54 ms are required before M2 can be used to estimate R2,iso* in subjects.
Gaze differences in configural and elemental evaluation during multi-attribute decision-making
Authors: Ryan-Lortie Juliette , Pelletier Gabriel , Pilgrim Matthew , Fellows Lesley K.
Published: August 2023

Introduction

While many everyday choices are between multi-attribute options, how attribute values are integrated to allow such choices remains unclear. Recent findings suggest a distinction between elemental (attribute-by-attribute) and configural (holistic) evaluation of multi-attribute options, with different neural substrates. Here, we asked if there are behavioral or gaze pattern differences between these putatively distinct modes of multi-attribute decision-making.

Methods

Thirty-nine healthy men and women learned the monetary values of novel multi-attribute pseudo-objects (fribbles) and then made choices between pairs of these objects while eye movements were tracked. Value was associated with individual attributes in the elemental condition, and with unique combinations of attributes in the configural condition. Choice, reaction time, gaze fixation time on options and individual attributes, and within- and between-option gaze transitions were recorded.

Results

There were systematic behavioral differences between elemental and configural conditions. Elemental trials had longer reaction times and more between-option transitions, while configural trials had more within-option transitions. The effect of last fixation on choice was more pronounced in the configural condition.

Discussion

We observed differences in gaze patterns and the influence of last fixation location on choice in multi-attribute value-based choices depending on how value is associated with those attributes. This adds support for the claim that multi-attribute option values may emerge either elementally or holistically, reminiscent of similar distinctions in multi-attribute object recognition. This may be important to consider in neuroeconomics research that involve visually-presented complex objects.
Possible role of locus coeruleus neuronal loss in age-related memory and attention deficits
Authors: Gargano Alessandra , Olabiyi Bolanle Fatimat , Palmisano Michela , Zimmer Andreas , Bilkei-Gorzo Andras
Published: August 2023

Introduction

Aging is associated with a decline in cognitive abilities, including memory and attention. It is generally accepted that age-related histological changes such as increased neuroinflammatory glial activity and a reduction in the number of specific neuronal populations contribute to cognitive aging. Noradrenergic neurons in the locus coeruleus (LC) undergo an approximately 20 % loss during ageing both in humans and mice, but whether this change contributes to cognitive deficits is not known. To address this issue, we asked whether a similar loss of LC neurons in young animals as observed in aged animals impairs memory and attention, cognitive domains that are both influenced by the noradrenergic system and impaired in aging.

Methods

For that, we treated young healthy mice with DSP-4, a toxin that specifically kills LC noradrenergic neurons. We compared the performance of DSP-4 treated young mice with the performance of aged mice in models of attention and memory. To do this, we first determined the dose of DSP-4, which causes a similar 20 % neuronal loss as is typical in aged animals.

Results

Young mice treated with DSP-4 showed impaired attention in the presence of distractor and memory deficits in the 5-choice serial reaction time test (5-CSRTT). Old, untreated mice showed severe deficits in both the 5-CSRTT and in fear extinction tests.

Discussion

Our data now suggest that a reduction in the number of LC neurons contributes to impaired working memory and greater distractibility in attentional tasks but not to deficits in fear extinction. We hypothesize that the moderate loss of LC noradrenergic neurons during aging contributes to attention deficits and working memory impairments.
Development, stabilization, and characterization of nanoemulsion of vitamin D3-enriched canola oil
Authors: Khalid Aafia , Arshad Muhammad Umair , Imran Ali , Haroon Khalid Syed , Shah Mohd Asif
Published: August 2023

In this study, the oil-in-water nanoemulsion (NE) was prepared and loaded with vitamin D3 in food-grade (edible) canola oil and stabilized by Tween 80 and Span 80 by using a water titration technique with droplet sizes of 20 to 200 nm. A phase diagram was established for the influence of water, oil, and S-Mix concentration. The outcomes revealed that the particle size of blank canola oil nanoemulsion (NE) ranged from 60.12 to 62.27 (d.nm) and vitamin D3 NE ranged from 93.92 to 185.5 (d.nm). Droplet size and polydispersity index (PDI) of both blank and vitamin D3-loaded NE results were less than 1, and zeta potential results for blank and vitamin D3 loaded NE ranged from −9.71 to −15.32 mV and −7.29 to −13.56 mV, respectively. Furthermore, the pH and electrical conductivity of blank NE were 6.0 to 6.2 and 20 to 100 (μs/cm), respectively, whereas vitamin D3-loaded NE results were 6.0 to 6.2 and 30 to 100 (μs/cm), respectively. The viscosity results of blank NE ranged from 0.544 to 0.789 (mPa.s), while that of vitamin D3-loaded NE ranged from 0.613 to 0.793 (mPa.s). In this study, the long-term stability (3 months) of canola oil NE containing vitamin D3 at room temperature (25 C) and high temperature (40 C) was observed.
Association between inflammatory bowel disease and pancreatic cancer: results from the two-sample Mendelian randomization study
Authors: Min Yu , Liu Zheran , Li Ruidan , Jin Jing , Wei Zhigong , Pei Yiyan , Hu Xiaolin , Peng Xingchen
Published: August 2023

Background

The nuanced relationship between inflammatory bowel disease (IBD) and pancreatic cancer is noticed in recent years. However, the underlying causal effects of these two diseases are still unclear.

Methods

The two-sample mendelian randomization (MR) was conducted to explore the causal effect of IBD condition on pancreatic cancer. Methods of Wald ratio, inverse variance weighted (IVW), MR-Egger, weighted median, and weighted mode were used to investigate the causal relationship between IBD and pancreatic cancer. Besides, Cochrane’s Q test, MR-Egger, and leave-one-out method were further conducted to detect heterogeneity, stability, and pleiotropy of MR results.

Results

In the MR analysis, we found Crohn’s disease had a significant causal effect on pancreatic cancer. Specifically, Crohn’s disease would increase 11.1% the risk of pancreatic cancer by the IVW method (p= 0.022), 33.8% by MR Egger (p= 0.015), by 35.3% by the Weighted model (p= 0.005). Regarding ulcerative colitis, there was no statistically significant causal effect observed on pancreatic cancer (p>0.05). Additionally, the pleiotropic test and Leave-one-out analysis both proved the validity and reliability of the present two-sample MR analyses.

Conclusion

This study indicates that IBD, particularly Crohn’s disease, is causality associated with increased risk of pancreatic cancer. Our results may help public health managers to make better follow-up surveillance of IBD patients.
Safe and effective removal of cyanoacrylate vascular access catheter securement adhesive in neonates
Authors: Hugill Kevin , van Rens Matheus F. P. T. , Alderman Angela , Kaczmarek Lori , Lund Carolyn , Paradis Amy
Published: August 2023

Neonatal vascular access continues to pose challenges. Recent times have seen considerable innovations in practice and the design and manufacture of materials used to provide infusion-based therapies with the intent of reducing the incidence and severity of vascular access-related complications. However, despite these efforts, vascular access-related complication rates remain high in this patient group and research evidence remains incomplete. In neonates, a medical-grade formulation of cyanoacrylate adhesive is widely used to secure percutaneously inserted central venous catheters and is beginning to establish a role in supporting the effective securement of other devices, such as umbilical and peripheral intravenous catheters. This Perspective article considers issues specific to the removal of cyanoacrylate used to secure vascular access devices from neonatal skin before its bonding releases due to natural skin exfoliation processes. The aim of this information is to ensure the safe and effective removal of octyl-cyanoacrylate adhesive-secured vascular access catheters from neonatal skin and stimulate professional discussion.
Comparison of the SenSmart™ and the INVOS™ neonatal cerebral near-infrared spectrometry devices
Authors: Wirayannawat Wariphan , Amawat Jutharat , Yamsiri Nattaya , Paes Bosco , Kitsommart Ratchada
Published: August 2023

Objectives

To determine the correlation and agreement between the SenSmart™ and the INVOS™ devices of neonatal cerebral regional oxygen saturation (CrSO2) measurements using neonatal sensors. The secondary objective was to develop a regression model that predicts CrSO2-INVOS values using CrSO2-SenSmart indices and determine whether the values between the devices are interchangeable.

Methods

A prospective, cross-sectional study was conducted in infants during the first 4 weeks of life. Simultaneous, bilateral CrSO2 was measured using the SenSmart™X100 (CrSO2-SenSmart) or INVOS™ 5100C (CrSO2-INVOS) device in each frontoparietal area for 2 h. Five-minute CrSO2 values were extracted for analysis.

Results

Thirty infants were recruited with 720 pairwise measurements and 26 (84%) were evaluated in the first week of life. Mean gestational age of the preterm and term infants was [30.9 ± 2.8 (n = 14) and 38.8 ± 1.1 (n = 16)] weeks, respectively. Overall CrSO2- was 77.08 ± 9.70% and 71.45 ± 12.74% for the SenSmart and INVOS, respectively (p < 0.001). The correlation coefficient (r) between the CrSO2-SenSmart and INVOS was 0.20 (p < 0.001). The mean difference between the CrSO2-SenSmart and INVOS was 5.63 ± 13.87% with −21.6% to 32.8% limits of agreement. The r and mean difference was 0.39 (p < 0.001) and 8.87 ± 12.58% in preterm infants, and 0.06 (p = 0.27) and 2.79 ± 14.34 in term infants.

Conclusion

The CrSO2-SenSmart tended to read higher than the CrSO2-INVOS device. There was no correlation between the CrSO2-SenSmart and the CrSO2-INVOS in term infants and it was weak in preterms. Due to imprecise agreement, the CrSO2-SenSmart values are not interchangeable with those of the CrSO2-INVOS.
Enhancing security and capacity in FSO transmission for next-generation networks using OFDM/OCDMA-based ICSM codes
Authors: Abd El-Mottaleb Somia A. , Singh Mehtab , Alshathri Samah , El-Shafai Walid , H. Aly Moustafa
Published: August 2023

In order to address the growing demands for both enhanced security levels and increased transmission capacity, this research proposes a novel approach for free space optical (FSO) transmission. The proposed design incorporates an identity column shift matrix (ICSM) code to ensure robust security. Additionally, capacity enhancement is achieved through the utilization of a 4-level quadrature amplitude modulation (4-QAM) scheme in conjunction with an orthogonal frequency division multiplexing (OFDM) modulator. The performance of the system is evaluated across three channels, each transmitting data at a rate of 20 Gb/s, while operating in an FSO channel that is subjected to varying atmospheric attenuation effects and atmospheric turbulence. Real meteorological data from three different cities [Alexandria, Egypt; Jeddah, Kingdom of Saudi Arabia (KSA); and Hyderabad, India], situated across two continents, are incorporated to demonstrate the practicality of implementing the proposed model in real-world environments. The experimental results reveal that an increase in atmospheric turbulence leads to a higher bit error rate (BER) and lower received optical power (ROP), resulting in degraded data reception. Furthermore, the study examines the impact of weather conditions, indicating that the longest and shortest propagation ranges of 12.5 and 0.286 km, respectively, are achieved under clear weather and heavy dust storms. These conditions yield an ROP of −9.5 dBm and a log (BER) of approximately −2.5. Conversely, in the presence of strong turbulence, the performance further deteriorates. The proposed model demonstrates its ability to transmit a message signal over a distance of 0.8375 km, with a log (BER) of −2.6 under weak atmospheric turbulence. However, under strong atmospheric turbulence at the same distance, the log (BER) increases to −0.5. Regarding specific cities, the FSO range for transmitting information signals is found to be 9.58 km in Jeddah, which decreases to 6.58 km in Alexandria and 5.17 km in Hyderabad due to the increased atmospheric attenuation in these cities.
Artificial placenta support of extremely preterm ovine fetuses at the border of viability for up to 336 hours with maintenance of systemic circulation but reduced somatic and organ growth
Authors: Usuda Haruo , Ikeda Hideyuki , Watanabe Shimpei , Sato Shinichi , Fee Erin L. , Carter Sean W. D. , Kumagai Yusaku , Saito Yuya , Takahashi Tsukasa , Takahashi Yuki , Kawamura Shinichi , Hanita Takushi , Saito Masatoshi , Kikuchi Atsuo , Choolani Mahesh A. , Yaegashi Nobuo , Kemp Matthew W.
Published: August 2023

Introduction: Artificial placenta therapy (APT) is an experimental life support system to improve outcomes for extremely preterm infants (EPI) less than 1,000 g by obviating the need for pulmonary gas exchange. There are presently no long-term survival data for EPI supported with APT. To address this, we aimed to maintain 95d-GA (GA; term-150d) sheep fetuses for up to 2 weeks using our APT system.

Methods: Pregnant ewes (n = 6) carrying singleton fetuses underwent surgical delivery at 95d GA. Fetuses were adapted to APT and maintained for up to 2 weeks with constant monitoring of key physiological parameters and extensive time-course blood and urine sampling, and ultrasound assessments. Six age-matched in-utero fetuses served as controls. Data were tested for group differences with ANOVA.

Results: Six APT Group fetuses (100%) were adapted to APT successfully. The mean BW at the initiation of APT was 656 ± 42 g. Mean survival was 250 ± 72 h (Max 336 h) with systemic circulation and key physiological parameters maintained mostly within normal ranges. APT fetuses had active movements and urine output constantly exceeded infusion volume over the experiment. At delivery, there were no differences in BW (with edema in three APT group animals), brain weight, or femur length between APT and in-utero Control animals. Organ weights and humerus lengths were significantly reduced in the APT group (p < 0.05). Albumin, IGF-1, and phosphorus were significantly decreased in the APT group (p < 0.05). No cases of positive blood culture were detected.

Conclusion: We report the longest use of APT to maintain extremely preterm fetuses to date. Fetal systemic circulation was maintained without infection, but growth was abnormal. This achievement suggests a need to focus not only on cardiovascular stability and health but also on the optimization of fetal growth and organ development. This new challenge will need to be overcome prior to the clinical translation of this technology.
Autonomic arousal detection and cardio-respiratory sleep staging improve the accuracy of home sleep apnea tests
Authors: Ross Marco , Fonseca Pedro , Overeem Sebastiaan , Vasko Ray , Cerny Andreas , Shaw Edmund , Anderer Peter
Published: August 2023

Introduction: The apnea-hypopnea index (AHI), defined as the number of apneas and hypopneas per hour of sleep, is still used as an important index to assess sleep disordered breathing (SDB) severity, where hypopneas are confirmed by the presence of an oxygen desaturation or an arousal. Ambulatory polygraphy without neurological signals, often referred to as home sleep apnea testing (HSAT), can potentially underestimate the severity of sleep disordered breathing (SDB) as sleep and arousals are not assessed. We aim to improve the diagnostic accuracy of HSATs by extracting surrogate sleep and arousal information derived from autonomic nervous system activity with artificial intelligence.

Methods: We used polysomnographic (PSG) recordings from 245 subjects (148 with simultaneously recorded HSATs) to develop and validate a new algorithm to detect autonomic arousals using artificial intelligence. A clinically validated auto-scoring algorithm (Somnolyzer) scored respiratory events, cortical arousals, and sleep stages in PSGs, and provided respiratory events and sleep stages from cardio-respiratory signals in HSATs. In a four-fold cross validation of the newly developed algorithm, we evaluated the accuracy of the estimated arousal index and HSAT-derived surrogates for the AHI.

Results: The agreement between the autonomic and cortical arousal index was moderate to good with an intraclass correlation coefficient of 0.73. When using thresholds of 5, 15, and 30 to categorize SDB into none, mild, moderate, and severe, the addition of sleep and arousal information significantly improved the classification accuracy from 70.2% (Cohen’s κ = 0.58) to 80.4% (κ = 0.72), with a significant reduction of patients where the severity category was underestimated from 18.8% to 7.3%.

Discussion: Extracting sleep and arousal information from autonomic nervous system activity can improve the diagnostic accuracy of HSATs by significantly reducing the probability of underestimating SDB severity without compromising specificity.
Effects of attachment security priming on women’s math performance
Authors: Soares De Almeida Antonio , Gillath Omri , Kahalon Rotem , Shnabel Nurit
Published: August 2023

Introduction

Activating people’s sense of attachment security can buffer against psychological threats. Here we tested whether security priming can also buffer the adverse effects of stereotype threat among women.

Method

Three studies (a pilot study (N = 79 women, 72 men), a laboratory study; N = 474 women, and an online study; N = 827 women) compared security priming to neutral and positive affect priming.

Results

The pilot study revealed that women exposed to attachment security primes (e.g., the word “love”) had better math performance than women exposed to neutral primes (e.g., “boat”). Men’s math performance did not differ across priming conditions. Study 1 revealed that women showed better math performance in the attachment security priming condition than in the neutral or positive (e.g., “luck”) priming conditions. The effect was observed among women high on math identification. In Study 2, despite an effect of security priming on the manipulation check [higher State Adult Attachment Measure (SAAM) security score], security did not buffer stereotype threat effects.

Discussion

Our findings provide partial support to the idea that security priming (an interpersonal process) can buffer stereotype threat (an intergroup process). Theoretical and practical implications related to attachment security priming and stereotype threat are discussed.
Research on the influence of family capital on academic achievement of first-generation college students in China
Authors: Zhao Ying , Wang Zhi , Ren Zengyuan
Published: August 2023

Objective

The objective of this study is to explore the influence of family capital (including family economic capital, family cultural capital and family social capital) on the academic achievement (including ability development, academic performance and self-concept) of first-generation college students.

Methods

The questionnaires are based on the CFPS (China Family Panel Studies) database and tailored to the specific circumstances. Data was collected from 1524 first-generation college students from five universities in Liaoning Province. SPSS 23.0 and AMOS 24.0 were used to analyze the data.

Results

Family economic capital significantly predicted ability development (standardized regression coefficient = 0.198, P < 0.001) and academic performance (standardized regression coefficient = 0.220, P < 0.001); Family cultural capital significantly predicted ability development (standardized regression coefficient = .114, P < 0.001), academic performance (standardized regression coefficient = 0.217, P < 0.001) and self-concept (standardized regression coefficient = 0.160, P < 0.001); Family social capital significantly predicted academic performance (standardized regression coefficient=0.084, P < 0.01) and self-concept (standardized regression coefficient = 0.156, P < 0.001).

Conclusion

Family capital can significantly affect the academic achievement of first-generation college students. To bridge the gap of academic achievement caused by family capital for first-generation college students and promote class mobility, special attention should be paid to the internal actions of students in higher education fields, the connection between different fields should be strengthened, and humanistic care for disadvantaged groups should be implemented.
A correlation study of music training, adult attachment, and personality traits using a large-sample questionnaire
Authors: Liu Ying , Liu Xiaolin , Zheng Maoping
Published: August 2023

Introduction

Music training can provide benefits to psychological health and is strongly associated with adult attachment style and personality traits through bidirectional interactions.

Methods

A large sample including 10,191 Chinese musicians and non-musicians completed the Relationship Questionnaire and Big-Five Personality Inventory.

Results

Connections between music training, adult attachment, and personality were analyzed with the following results: (1) personality traits were correlated with attachment dimensions, with positive correlations between secure attachment and extroversion and between dismissing attachment and neuroticism; (2) music training was connected with the secure and fearful-avoidant attachment dimensions, which complemented the effect of educational level in the preoccupied and dismissing dimensions; (3) music training enhanced extroversion, openness, agreeableness, and conscientiousness, which interacted to affect extroversion and openness by gender; and (4) music training enhanced the regression of extroversion to preoccupied and secure attachments, and the regression of openness to preoccupied attachment.

Discussion

Conclusively, music training enhanced the connection between secure attachment and positive personality traits and regulated the correlation between insecure attachment and neuroticism. This analysis provides a large sample of statistical and practical evidence for the clinical practices of mental health and the educational and music training practices of co-cultivating cultural knowledge and artistic quality.
Investigating the association of physical and psychological problems with the levels of interleukin-1 and -6 in COVID-19 patients
Authors: Bahadori-Birgani Galia , Molavynejad Shahram , Rashidi Mahbobe , Amiri Fereshteh , Maraghi Elham , Dashtbozorgi Bahman , Ulhaq Zulvikar Syambani , Alizadeh-Attar Gholamreza
Published: August 2023

Introduction

The COVID-19 virus spreads at a high rate, exerting many physical, mental and psychological effects on patients. Patients with COVID-19 have been reported to have high levels of interleukin 1 and interleukin 6. Therefore, this study was conducted to determine the association of physical, mental, and psychological problems with the levels of interleukin-1 and -6 in COVID-19 patients.

Methodology

This is cross-sectional descriptive-analytical research on 121 COVID-19 patients selected using simple random sampling method. The patients were hospitalized in university hospitals affiliated to Ahvaz Jundishapur University of Medical Sciences and Amir al-Momenin Hospital. Data collection tools included the depression anxiety stress scale (DASS), a demographic questionnaire, and a checklist of physical problems. Blood sampling was also done to perform an ELISA test and measure the level of interleukin-1 and -6. Data were analyzed based on independent t-tests, chi-square, regression, and Pearson’s correlation coefficient, using SPSS ver. 22.

Results

The average age of the 121 patients participating in this study was 53.31 ± 14.09. A direct and statistically significant correlation was observed between body temperature on the first day and interleukin 1 level. A statistically significant negative correlation was observed between blood oxygen saturation level and interleukin-1 and -6 on the first, third and fifth days. Shortness of breath and coughing had a statistically significant correlation with the level of interleukin 1 on the third and fifth days. A direct and statistically significant correlation was observed between body temperature on the first, third and fifth days and interleukin 6 level. Coughing on the third and fifth days had a statistically significant relationship with interleukin 6 level. No direct and non-significant statistical correlation was found between depression and stress and the serum level of interleukin 1, but a significant correlation was observed between anxiety and serum level of interleukin 1. Finally, the results showed that depression, anxiety and stress had a direct and statistically significant correlation with the serum level of interleukin 6.

Conclusion

Given the relationship between interleukin-1 and -6 and most physical and psychological problems, level of the inflammatory biomarkers interleukin-1 and -6 can be used to estimate the severity of physical and psychological symptoms in COVID-19 patients.
Shaping undergraduate public health education through critical race theory: a case study
Authors: Tagorda-Kama Michelle A. , Patil Uday , Chung-Do Jane J. , Kehl Lisa , Antonio Mapuana C. K. , Nelson-Hurwitz Denise C.
Published: August 2023

In 2020, the American Public Health Association declared structural racism a public health crisis acknowledging the long-lasting and harmful effects of prejudice, including relatively high rates of morbidity and mortality in many communities of color. Critical Race Theory (CRT) has become an essential lens to view and reconsider education’s role in perpetuating racial and ethnic discrimination. Debates over integrating CRT in higher education with the intent to acknowledge and address racial equality and justice are more present than ever, and the discussions held in public health classrooms are no different. We present a case study of CRT integration into the Bachelor of Arts in Public Health (BAPH) program at the University of Hawaiʻi at Mānoa. In line with Solorzano’s framework of CRT in education, initial goals of integrating CRT in instruction and advising included fostering discussions of race and racism, using a social justice framework to highlight opportunities to reduce health inequities, and validating the experiential knowledge of people of color. By engaging in active discussions with community leaders and participating in experiential learning throughout the program, students develop empathy and many underrepresented and marginalized students engage actively in their home communities. Specific examples of CRT integrated in the curriculum and examples of student projects that integrate a CRT lens are provided for educators and researchers.
Participation of university community members in Health Promoting University (HPU) initiatives
Authors: Suárez-Reyes Mónica , Van den Broucke Stephan
Published: August 2023

Background

Several universities around the world have adopted the settings approach to health to create a Health Promoting University (HPU) initiative. Health promoting initiatives are built on the values of health promotion, with participation being one of the most important. Despite the above, there is little information on how university community members participate in HPU initiatives. This study aims to describe the participation of university community members in HPU initiatives in universities around the world.

Methods

An online questionnaire was sent to representatives of universities that have implemented a HPU initiative. The questionnaire inquired about the level and nature of participation of university community members (students, professors, and administrative/technical staff) at different levels. Three levels of participation ranged from lower to higher levels were considered: (a) information delivery strategies; (b) consultation strategies and (c) involvement in design, planning and decision-making processes.

Results

At least the 50% of the universities implemented strategies so that all the members of the community could participate at all levels. Information delivery strategies were the most often used, with students being the main target group. Consultation strategies were aimed mainly at students and professors, whilst professors participated most actively in the design, planning and decision-making.

Conclusion

Different participation strategies are used in the HPU initiatives. Information delivery strategies, which represent the lowest level of participation, were the most often reported. Higher levels of participation were less used in the HPU initiatives. HPU initiatives should seek for strategies to provide more high-level participation to all university community members.