bluuebunny/crossref_metadata_2025 huggingface dataset:
Personalized quantitative models of NAD metabolism in hepatocellular carcinoma identify a subgroup with poor prognosis
Authors: Chedere Adithya , Mishra Madhulika , Kulkarni Omkar , Sriraman Shrisruti , Chandra Nagasuma
Published: September 2022

Cancer cells are known to undergo metabolic adaptation to cater to their enhanced energy demand. Nicotinamide adenine dinucleotide (NAD) is an essential metabolite regulating many cellular processes within the cell. The enzymes required for NAD synthesis, starting from the base precursor - tryptophan, are expressed in the liver and the kidney, while all other tissues convert NAD from intermediate precursors. The liver, being an active metabolic organ, is a primary contributor to NAD biosynthesis. Inhibition of key enzymes in the NAD biosynthetic pathways is proposed as a strategy for designing anti-cancer drugs. On the other hand, NAD supplementation has also been reported to be beneficial in cancer in some cases. As metabolic adaptation that occurs in cancer cells can lead to perturbations to the pathways, it is important to understand the exact nature of the perturbation in each individual patient. To investigate this, we use a mathematical modelling approach integrated with transcriptomes of patient samples from the TCGA-LIHC cohort. Quantitative profiling of the NAD biosynthesis pathway helps us understand the NAD biosynthetic status and changes in the controlling steps of the pathway. Our results indicate that NAD biosynthesis is heterogeneous among liver cancer patients, and that Nicotinate phosphoribosyl transferase (NAPRT) levels are indicative of the NAD biosynthetic status. Further, we find that reduced NAPRT levels combined with reduced Nicotinamide phosphoribosyl transferase (NAMPT) levels contribute to poor prognosis. Identification of the precise subgroup who may benefit from NAD supplementation in subgroup with low levels of NAPRT and NAMPT could be explored to improve patient outcome.
Transarterial chemoembolization combined with apatinib with or without PD-1 inhibitors in BCLC stage C hepatocellular carcinoma: A multicenter retrospective study
Authors: Xia Wei-Li , Zhao Xiao-Hui , Guo Yuan- , Cao Guang-Shao , Wu Gang , Fan Wei-Jun , Yao Quan-Jun , Xu Shi-Jun , Guo Chen-Yang , Hu Hong-Tao , Li Hai-Liang
Published: September 2022

Objective

We evaluated the efficacy and safety of transarterial chemoembolization (TACE) combined with apatinib plus PD-1 inhibitors (TACE-AP) compared with TACE combined with apatinib (TACE-A) in patients with advanced hepatocellular carcinoma (HCC) and to explore the prognostic factors affecting patient survival.

Methods

Data from patients with unresectable HCC who received TACE-AP or TACE-A from December 2018 to June 2021 were collected retrospectively. The main outcome of the study was overall survival (OS) and prognostic factors affecting survival, while the secondary outcomes were progression-free survival (PFS), the objective response rate (ORR), and treatment-related adverse events (TRAEs). Propensity score matching (PSM) analysis was used to reduce patient selection bias, and the random survival forest (RF) model was employed to explore prognostic factors affecting patient survival.

Results

We enrolled 216 patients, including 148 and 68 patients in the TACE-A and TACE-AP groups, respectively. A total of 59 pairs of patients were matched using PSM analysis. Before and after PSM, the OS, PFS, and ORR in the TACE-AP group were significantly higher than in the TACE-A group (before, OS: 22.5 months vs. 12.8 months, P < 0.001; PFS: 6.7 months vs. 4.3 months, P < 0.001; ORR: 63.2% vs. 34.5%, P < 0.001; after, OS: 22.5 months vs. 12.0 months, P < 0.001; PFS: 6.7 months vs. 4.3 months, P < 0.001; ORR: 62.7% vs. 30.5%, P = 0.003). Multivariate Cox regression and RF models before and after PSM analysis revealed that the main prognostic factors affecting survival were tumor number, portal vein tumor thrombus (PVTT) invasion, alpha-fetoprotein (AFP) levels, total bilirubin (TBIL) level, and treatment. There was no significant difference in TRAEs between the two groups (P > 0.05).

Conclusion

Compared with TACE-A, TACE-AP significantly improved OS, PFS, and ORR in patients with advanced HCC. The number of tumors, PVTT invasion, AFP levels, TBIL level, and treatment were significant prognostic factors associated with patient survival. All observed TRAEs were mild and controllable.
Impact of adjuvant radiation therapy after definitive surgery in senior adults >80 years old with advanced head and neck squamous cell carcinoma on overall survival
Authors: Butkus Joann M. , Crippen Meghan , Bar-Ad Voichita , Luginbuhl Adam
Published: September 2022

Background

Adjuvant radiotherapy (RT) following surgical resection confers a survival benefit for adult patients with locally advanced head and neck squamous cell carcinoma (HNSCC). We aim to investigate if adjuvant RT provides a similar survival advantage to patients ages 80+ through a national curated database.

Methods

This retrospective cohort study queried the National Cancer Database (NCDB) for all cases of HNSCC between 2004-2016. Patients treated with surgical resection alone were compared to those treated with surgery plus adjuvant RT. Overall survival (OS) was compared within adult (age <80 years) and senior adult (age ≥80 years) cohorts using Kaplan-Meier analysis. Hazard ratios (HR) were assessed using Cox proportional hazards to account for differences in patient characteristics, primary site, and HNSCC stage.

Results

NCDB identified 16,504 locally advanced HNSCC treated with definitive surgery with 9,129 (55.3%) also receiving adjuvant RT. The mean age was 63.8 years (SD = 12.0) with 88.7% of patients ages <80 years and 11.3% ages ≥80 years. In the adult cohort, adjuvant RT was associated with a significant increase in OS compared to surgery alone at 1 year (88.4% vs. 83.8%, p=<0.001), 3 years (64.0% vs. 59.2%, p=<0.001) and 5 years (52.8% vs. 47.2%, p=<0.001). Treatment with surgery alone remained a significant predictor of mortality risk at 1 year (HR 1.48, 95% CI 1.35-1.64, p<0.001), 3 years (HR 1.25, 95% CI 1.18-1.33, p<0.001), and 5 years (HR of 1.23, 95% CI 1.17-1.30, p=<0.001). In the senior adult cohort, there were no significant differences in OS between treatment groups at 1 year (73.4% vs. 74.8%, 0.296), 3 years (45.8% vs. 41.8%, p=0.465), or 5 years (28.2% vs. 27.7% p=0.759). Treatment with surgery alone was not a significant predictor of mortality risk at 1 year (HR 1.11, 95% CI 0.90-1.36, p=0.316), 3 years (HR 0.94, 95% CI 0.81-1.08, p=0.423), or 5 years (HR 0.95, 95% CI 0.83-1.08, p=0.476).

Conclusion

The addition of adjuvant RT in senior patients (age ≥80 years) may not provide a similar OS benefit to that observed in younger patients. Further research is needed to best guide shared-decision making in this population.
Treatment of myocardial interstitial fibrosis in pathological myocardial hypertrophy
Authors: Zhu Fuyu , Li Peng , Sheng Yanhui
Published: September 2022

Pathological myocardial hypertrophy can be caused by a variety of diseases, mainly accompanied by myocardial interstitial fibrosis (MIF), which is a diffuse and patchy process, appearing as a combination of interstitial micro-scars and perivascular collagen fiber deposition. Different stimuli may trigger MIF without cell death by activating a variety of fibrotic signaling pathways in mesenchymal cells. This manuscript summarizes the current knowledge about the mechanism and harmful outcomes of MIF in pathological myocardial hypertrophy, discusses the circulating and imaging biomarkers that can be used to identify this lesion, and reviews the currently available and potential future treatments that allow the individualized management of patients with pathological myocardial hypertrophy.
Characterization of exogenous αSN response genes and their relation to Parkinson’s disease using network analyses
Authors: Nayeri Zahra , Aliakbari Farhang , Afzali Farzaneh , Parsafar Soha , Gharib Ehsan , Otzen Daniel E. , Morshedi Dina
Published: September 2022

Despite extensive research, the molecular mechanisms underlying the toxicity of αSN in Parkinson’s disease (PD) pathology are still poorly understood. To address this, we used a microarray dataset to identify genes that are induced and differentially expressed after exposure to toxic αSN aggregates, which we call exogenous αSN response (EASR) genes. Using systems biology approaches, we then determined, at multiple levels of analysis, how these EASR genes could be related to PD pathology. A key result was the identification of functional connections between EASR genes and previously identified PD-related genes by employing the proteins’ interactions networks and 9 brain region-specific co-expression networks. In each brain region, co-expression modules of EASR genes were enriched for gene sets whose expression are altered by SARS-CoV-2 infection, leading to the hypothesis that EASR co-expression genes may explain the observed links between COVID-19 and PD. An examination of the expression pattern of EASR genes in different non-neurological healthy brain regions revealed that regions with lower mean expression of the upregulated EASR genes, such as substantia nigra, are more vulnerable to αSN aggregates and lose their neurological functions during PD progression. Gene Set Enrichment Analysis of healthy and PD samples from substantia nigra revealed that a specific co-expression network, “TNF-α signaling via NF-κB”, is an upregulated pathway associated with the PD phenotype. Inhibitors of the “TNF-α signaling via NF-κB” pathway may, therefore, decrease the activity level of this pathway and thereby provide therapeutic benefits for PD patients. We virtually screened FDA-approved drugs against these upregulated genes (NR4A1, DUSP1, and FOS) using docking-based drug discovery and identified several promising drugs. Altogether, our study provides a better understanding of αSN toxicity mechanisms in PD and identifies potential therapeutic targets and small molecules for treatment of PD.
Fruits of Hippophaë rhamnoides in human leukocytes and Caco-2 cell monolayer models—A question about their preventive role in lipopolysaccharide leakage and cytokine secretion in endotoxemia
Authors: Laskowska Anna K. , Wilczak Aleksandra , Skowrońska Weronika , Michel Piotr , Melzig Matthias F. , Czerwińska Monika E.
Published: September 2022

Preparations from Hippophaë rhamnoides L. (sea buckthorn) have been traditionally used in the treatment of skin and digestive disorders, such as gastritis, gastric and duodenal ulcers, uterine erosions, as well as oral, rectal, and vaginal mucositis, in particular in the Himalayan and Eurasian regions. An influence of an aqueous extract from the fruits of H. rhamnoides (HR) on leakage of lipopolysaccharide (LPS) from Escherichia coli through gut epithelium developed from the human colorectal adenocarcinoma (Caco-2) monolayer in vitro and glucose transporter 2 (GLUT2) translocation were the principal objectives of the study. Additionally, the effect of HR on the production of pro- and anti-inflammatory cytokines (interleukins: IL-8, IL-1β, IL-10, IL-6; tumor necrosis factor: TNF-α) by the Caco-2 cell line, human neutrophils (PMN), and peripheral blood mononuclear cells (PBMC) was evaluated. The concentration of LPS on the apical and basolateral sides of the Caco-2 monolayer was evaluated with a Limulus Amebocyte Lysate (LAL) assay. GLUT2 translocation was evaluated using an immunostaining assay, whereas secretion of cytokines by cell cultures was established with an enzyme-linked immunosorbent (ELISA) assay. HR (500 μg/ml) significantly inhibited LPS leakage through epithelial monolayer in vitro in comparison with non-treated control. The treatment of Caco-2 cells with HR (50–100 μg/ml) showed GLUT2 expression similar to the non-treated control. HR decreased the secretion of most pro-inflammatory cytokines in all tested models. HR might prevent low-grade chronic inflammation caused by metabolic endotoxemia through the prevention of the absorption of LPS and decrease of chemotactic factors released by immune and epithelial cells, which support its use in metabolic disorders in traditional medicine.
The gut-lung axis: Gut microbiota changes associated with pulmonary fibrosis in mouse models induced by bleomycin
Authors: Quan Yunyun , Yin Zhujun , Chen Shilong , Lang Jirui , Han Liyang , Yi Jing , Zhang Lu , Yue Qianhua , Tian Weiwei , Chen Ping , Du Shenglin , Wang Jianbo , Dai Ying , Hua Hua , Zeng Jin , Li Li , Zhao Junning
Published: September 2022

The main objective of this study was to investigate the alterations in the gut microbiota (GM) of pulmonary fibrosis (PF) mice induced by bleomycin (BLM) with its underlying mechanisms. BLM was docked with the targets of TGF-β/SMAD and caspase-3 pathways using the molecular docking technique. HE staining and Masson staining were applied to observe the histopathological changes in the pulmonary tissues. Detection of the apoptotic signals was conducted by flow cytometry and TUNEL staining. The mRNA expression of targets involved in the TGF-β/SMAD and caspase-3 signaling pathways in lungs was determined by qPCR. Immunohistochemistry (IHC) assay was used to detect the expression levels of cleaved caspase-3 and BAX proteins in mice lung tissues. 16S rDNA sequencing analysis was used to investigate the changes of GM in the fecal samples of mice in each group. The results showed that the apoptosis rate of pulmonary cells in the BLM group distinctly increased, with the expression levels of crucial target pro-apoptotic gene caspase-3, BAX with the corresponding protein, cleaved caspase-3, BAX were apparently elevated. This was accompanied by a significant increase in pro-fibrotic targets level such as TGF-β, fibronectin, collagen I, and collagen III. The mechanisms of PF induced by BLM were related to apoptosis of lung tissue cells such as alveolar epithelial cells and destroyed alveolar structure and excessive production of extracellular matrix (ECM), which may be bound up with activating TGF-β/SMAD and caspase-3 pathways. As for the GM, it was found that, after BLM induced PF in mice, the micro ecological balance of the GM was destroyed; the distance of PCo1 and Pco2 was significantly elongated, and the relative abundance of some intestinal probiotics like Catenibacterium and Lactobacillus (L. johnsonii and L. gasseri) dramatically lowered while the relative abundance of Verrucomicrobiales and Enterobacteriales substantially increased. Therefore, GM changes associated with PF in mouse models induced by BLM and the concept of “gut-lung axis” might provide an optional therapeutic strategy for PF.
Scutellaria baicalensis Georgi regulates REV-ERBα/BMAL1 to protect against skin aging in mice
Authors: Sun Guanghui , Dang Yongkang , Lin Yanke , Zeng Wanying , Wu Zongjian , Zhang Xingwang , Dong Dong , Wu Baojian
Published: September 2022

Scutellaria baicalensis Georgi (SBG) is a traditional Chinese medicine widely used to treat disorders such as hypertension, dysentery and hemorrhaging. Here, we aimed to assess the pharmacological effects of SBG on skin aging and to investigate the underlying mechanisms. Mice with skin aging were established by treatment with D-galactose and ultraviolet-B. SBG (topical application) showed a protective effect on skin aging in mice, as evidenced by less formation of skin wrinkles, higher levels of SOD (superoxide dismutase) and HYP (hydroxyproline) as well as a lower level of MDA (malondialdehyde). In the meantime, skin MMP-1 and p53 expression were lower, epidermis was thinner and collagen amount was higher in SBG-treated mice. Anti-skin aging effects of SBG were also confirmed in NIH3T3 and HaCaT cells, as well as in mouse primary dermal fibroblasts and human primary epidermal keratinocytes. Furthermore, we found that loss of Rev-erbα (a known repressor of Bmal1) up-regulated skin BMAL1 (a clock component and a known anti-aging factor) and ameliorated skin aging in mice. Moreover, SBG dose-dependently increased the expression of BMAL1 in the skin of aged mice and in senescent NIT3H3 cells. In addition, based on a combination of Gal4 chimeric, luciferase reporter and expression assays, SBG was identified as an antagonist of REV-ERBα and thus an inducer of BMAL1 expression. In conclusion, SBG antagonizes REV-ERBα to up-regulate BMAL1 and to protect against skin aging in mice.
The roles and targeting options of TRIM family proteins in tumor
Authors: Zhang Yuxin , Zhang Wenzhou , Zheng Lufeng , Guo Qianqian
Published: September 2022

Tripartite motif (TRIM) containing proteins are a class of E3 ubiquitin ligases, which are critically implicated in the occurrence and development of tumors. They can function through regulating various aspects of tumors, such as tumor proliferation, metastasis, apoptosis and the development of drug resistance during tumor therapy. Some members of TRIM family proteins can mediate protein ubiquitination and chromosome translocation via modulating several signaling pathways, like p53, NF-κB, AKT, MAPK, Wnt/β-catenin and other molecular regulatory mechanisms. The multi-domain nature/multi-functional biological role of TRIMs implies that blocking just one function or one domain might not be sufficient to obtain the desired therapeutic outcome, therefore, a detailed and systematic understanding of the biological functions of the individual domains of TRIMs is required. This review mainly described their roles and underlying mechanisms in tumorigenesis and progression, and it might shade light on a potential targeting strategy for TRIMs in tumor treatment, especially using PROTACs.
Free-radical fluorescence emissions induced by 1,030 nm femtosecond laser filamentation in ethanol flame
Authors: Li Ziting , Chen Jinming , Liu Zhaoxiang , Li Yi , Chu Yuxi , Chen Ye , Cheng Ya
Published: September 2022

We experimentally investigated clean optical emissions from multiple combustion intermediates including free radicals C2, CH, and CN at multiple wavelengths induced by ultrashort 1,030-nm laser pulses. We systematically study the evolution of the fluorescence emissions induced by the femtosecond laser filament in the combustion field with the parameters such as the laser pulse energy, pulse duration, and focal length. Compared with the previous work, we promote that the fluorescence emissions of the combustion product can be manipulated effectively by controlling the femtosecond laser characteristics including pulse energy, duration, and the focusing conditions. This process helps to optimize its signal-to-noise ratio, which provides a further application of the femtosecond laser pulses to sense the combustion intermediates.
Long-term stimulation with alternating electric fields modulates the differentiation and mineralization of human pre-osteoblasts
Authors: Sahm Franziska , Freiin Grote Vivica , Zimmermann Julius , Haack Fiete , Uhrmacher Adelinde M. , van Rienen Ursula , Bader Rainer , Detsch Rainer , Jonitz-Heincke Anika
Published: September 2022

Biophysical stimulation by electric fields can promote bone formation in bone defects of critical size. Even though, long-term effects of alternating electric fields on the differentiation of osteoblasts are not fully understood. Human pre-osteoblasts were stimulated over 31 days to gain more information about these cellular processes. An alternating electric field with 0.7 Vrms and 20 Hz at two distances was applied and viability, mineralization, gene expression, and protein release of differentiation factors were analyzed. The viability was enhanced during the first days of stimulation. A higher electric field resulted in upregulation of typical osteogenic markers like osteoprotegerin, osteopontin, and interleukin-6, but no significant changes in mineralization. Upregulation of the osteogenic markers could be detected with a lower electric field after the first days of stimulation. As a significant increase in the mineralized matrix was identified, an enhanced osteogenesis due to low alternating electric fields can be assumed.
Impacts of Moso bamboo (Phyllostachys pubescens) invasion on species diversity and aboveground biomass of secondary coniferous and broad-leaved mixed forest
Authors: Chen Xi , Chen Xin , Huang Shiqi , Fang Dongming
Published: September 2022

In recent decades, Moso bamboo has been largely increasing in the subtropical area of China, raising ecological concerns about its invasion into other native forest ecosystems. One concern is whether the invasion of Moso bamboo significantly simplifies forest community composition and structure and declines biomass. This study adopted the space-for-time method to investigate a secondary coniferous and broad-leaved mixed forest (SF) being invaded by an adjacent Moso bamboo forest (MB) in the Wuxie forest reserve, Zhejiang Province. Three plots were established in each SF, MB, and transitional forest. The results showed that the species composition and species dominance of the arborous layer changed significantly (P < 0.05), which was indicated by the significantly decreased species richness (Margalef index, Shannon–Wiener index, and Simpson index) and evenness (Pielou evenness index). In contrast, the species richness of the shrub and herbaceous layers had two divergent indications (increasing or unchanged), and the evenness remained unchanged. The total and arborous-layer aboveground biomass of the forest community has had no noticeable change (P < 0.05). However, the biomass of the shrub and herbaceous layers showed an increasing trend (shrub significant but herbaceous not), but they only occupied a small proportion (∼1%) of the total biomass. Finally, the aboveground biomass and the diversity index had no significant correlation in each layer and overall stands. We hope that the findings could provide a theoretical basis for the invasion mechanism and ecological consequences of the Moso bamboo invasion.
Wheat lodging extraction using Improved_Unet network
Authors: Yu Jun , Cheng Tao , Cai Ning , Lin Fenfang , Zhou Xin-Gen , Du Shizhou , Zhang Dongyan , Zhang Gan , Liang Dong
Published: September 2022

The accurate extraction of wheat lodging areas can provide important technical support for post-disaster yield loss assessment and lodging-resistant wheat breeding. At present, wheat lodging assessment is facing the contradiction between timeliness and accuracy, and there is also a lack of effective lodging extraction methods. This study aims to propose a wheat lodging assessment method applicable to multiple Unmanned Aerial Vehicle (UAV) flight heights. The quadrotor UAV was used to collect high-definition images of wheat canopy at the grain filling and maturity stages, and the Unet network was evaluated and improved by introducing the Involution operator and Dense block module. The performance of the Improved_Unet was determined using the data collected from different flight heights, and the robustness of the improved network was verified with data from different years in two different geographical locations. The results of analyses show that (1) the Improved_Unet network was better than other networks (Segnet, Unet and DeeplabV3+ networks) evaluated in terms of segmentation accuracy, with the average improvement of each indicator being 3% and the maximum average improvement being 6%. The Improved_Unet network was more effective in extracting wheat lodging areas at the maturity stage. The four evaluation indicators, Precision, Dice, Recall, and Accuracy, were all the highest, which were 0.907, 0.929, 0.884, and 0.933, respectively; (2) the Improved_Unet network had the strongest robustness, and its Precision, Dice, Recall, and Accuracy reached 0.851, 0.892, 0.844, and 0.885, respectively, at the verification stage of using lodging data from other wheat production areas; and (3) the flight height had an influence on the lodging segmentation accuracy. The results of verification show that the 20-m flight height performed the best among the flight heights of 20, 40, 80 and 120 m evaluated, and the segmentation accuracy decreased with the increase of the flight height. The Precision, Dice, Recall, and Accuracy of the Improved_Unet changed from 0.907 to 0.845, from 0.929 to 0.864, from 0.884 to 0.841, and from 0.933 to 0.881, respectively. The results demonstrate the improved ability of the Improved-Unet to extract wheat lodging features. The proposed deep learning network can effectively extract the areas of wheat lodging, and the different height fusion models developed from this study can provide a more comprehensive reference for the automatic extraction of wheat lodging.
The roles of financial literacy and overconfidence in investment decisions in Saudi Arabia
Authors: Seraj Abdullah Hamoud Ali , Alzain Elham , Alshebami Ali Saleh
Published: September 2022

Financial literacy has gained much attention amongst scholars, policymakers and other stakeholders due to its role in backing up investment decisions, improving personal financial management and increasing financial wellbeing. This study examines the influence of financial literacy on investment decisions with the moderating effect of the overconfidence behavioural bias. Data were collected from 180 respondents in Saudi Arabia using a questionnaire, and a convenience sampling technique was applied. The study’s findings were analysed using the partial least squares structural equation modelling (PLS-SEM) technique. It was found that financial literacy positively and significantly influenced investment decisions. Moreover, the results show that overconfidence positively affected investment decisions and that the relationship between financial literacy and investment decisions was positively and significantly moderated by overconfidence.
Dimensionality and reliability of the Depression Anxiety Stress Scales 21 among adolescents in North Macedonia
Authors: Naumova Katerina
Published: September 2022

This study examined the structural validity and reliability of the DASS-21 in a large sample (N = 4,202) of secondary school students from North Macedonia (Mage = 16.43 ± 1.04, 65% girls). Based on theoretical and empirical considerations, five structural models were compared using confirmatory factor analysis. The original three-factor model provided good fit to the data; however, high interfactor correlations indicated that the depression, anxiety, and stress factors were indistinguishable. The bifactor solution yielded superior fit relative to other tested models. Factor loading patterns revealed a strong general factor and some specificity of the depression and anxiety factors, whereas the stress items were primarily markers of general distress. Model-based reliability and ancillary bifactor indices revealed that the DASS-21 is essentially unidimensional. Thus, only the total score could be used as a reliable measure of general emotional distress, while subscale scores should be avoided. Overall, the findings provide further support for the cross-cultural validity of the DASS-21 and confirm that it is suitable for use among older adolescents in North Macedonia.
Influence of distributive justice on organizational citizenship behaviors: The mediating role of gratitude
Authors: Bala Subramanian R. , Srikanth P. B. , Thakur Munish
Published: September 2022

Distributive justice is known to have important emotional and affective outcomes. The present study explores the role of distributive justice as an antecedent to feelings of gratitude toward the organization. Borrowing from social exchange theory, we investigate the mediating role of gratitude in the relationship between “perceived fairness in distributive justice” and “employees’ organization citizenship behaviors (OCB).” Time-lagged, multi-source data was collected from 185 employees and their supervisors employed in a large manufacturing organization based in East India. Two significant findings emerge. First, the results indicate that feelings of gratitude signal fair distribution of benefits such that the employees go beyond the call of the duty to invest in OCB. Second, engagement in such acts seems to nullify their social debts highlighted in the social exchange perspective. Thus, a strong moral emotion, gratitude is a powerful vehicle that drives employees to act in the organization’s interests because doing is desirable and rightful. Implications for theory and practice are discussed.
The role of empathy between peers in upper secondary students’ study engagement and burnout
Authors: Tikkanen Lotta , Anttila Henrika , Pyhältö Kirsi , Soini Tiina , Pietarinen Janne
Published: September 2022

Having the ability to understand emotionally how other people feel and see things is an essential fabric for building and sustaining functional interpersonal relationships. Without such an ability, social interaction crumbles, engagement fails, and learning is eroded. Yet, empirical evidence on the relationship between study burnout and study engagement, and empathy between upper secondary school students is limited. We are tackling the challenge by exploring the association between empathy between peers and study engagement and study burnout among upper secondary school students. Two hundred and eighty upper secondary education students took part in our cross-sectional study. Structural equation modeling was used to analyze the association between empathy (i.e., cognitive and affective empathy), and study burnout and study engagement. The results showed that cognitive empathy contributed to affective empathy, which was further related to increased levels of study engagement, and decreased levels of cynicism, and sense of inadequacy. The role of cognitive empathy seemed to be more complicated: while cognitive empathy contributed directly to increased levels of cynicism, and inadequacy and decrease in study engagement, the indirect effects of cognitive empathy (through affective empathy) on cynicism and inadequacy were negative, and positive on study engagement. Neither of the empathy dimensions explained students’ emotional exhaustion. The results indicate that merely teaching students to recognize and identify their peers’ emotions is not sufficient to enhance study wellbeing, but they need to learn to share emotions and to tune into each other’s emotions.
Insecure adult attachment and reflective functioning as mechanisms of the relationship between traumatic life events and suicidal ideation: A path analysis
Authors: Musetti Alessandro , Pingani Luca , Zagaria Andrea , Uberti Daniele , Meli Salvatore , Lenzo Vittorio , Gori Alessio , Franceschini Christian , Galeazzi Gian Maria
Published: September 2022

The relationship between traumatic life events and increased suicide risk has been well reported in literature. However, the complex nature of suicidality phenomena still hinders our ability to comprehend the mediation mechanism underlying this association. In this study, we examined the mediating role of adult attachment and reflective functioning in the relationship between traumatic life events and suicidal ideation. Nine hundred and fifty Italian adults completed an online survey evaluating traumatic life events, adult attachment, reflective functioning and suicidal ideation. The path analysis showed that the positive relationship between traumatic life events and suicidal ideation was partially mediated by attachment anxiety and reflective functioning. From a clinical point of view, these results support the relevance of evaluating and improving patients’ ability to mentalize as a part of psychotherapeutic intervention aimed at reducing suicidality in people with a history of traumatic experiences and attachment anxiety.
“Antibiotics are for everyone, our past and our future generations, right? If antibiotics are dead, we will be in big trouble”: Building on community values for public engagement on appropriate use of antibiotics in Singapore
Authors: Guo Huiling , Hildon Zoe Jane-Lara , Chow Angela
Published: September 2022

Introduction

Shared decision-making (SDM) and trust building through continuity of care are known to play a pivotal role in improving appropriate antibiotic prescribing and use.

Problem

However, less is known about how to effectively leverage these factors when present—or overcome them when not—to address community needs and improve patient liaison.

Methods

We addressed this question using a convergent parallel mixed-methods design. Focus group discussions (N = 13; August 2018–September 2020), were analyzed alongside a nationally-representative cross-sectional survey (N = 2004; November 2020–January 2021), in Singapore. Descriptive quantitative analyses and multivariable logistic regression were undertaken to examine antibiotic knowledge and factors associated with preference for SDM. Qualitative applied thematic analysis was integrated with these data to further explain the findings.

Findings

Poor knowledge and misbeliefs on appropriate antibiotic use and antimicrobial resistance (AMR) were identified. For example, only 9% of the surveyed population understood that AMR occurs when the bacteria, not the human body, become resistant to antibiotics. Qualitative data corroborated the survey findings and suggested a shared value was placed on public education to avoid the fallout from resistant bacterial strains on current and future generations. This study also identified the opportunity to harness community trust in primary care doctors, who were described as highly valued educators for antibiotic use and AMR. Those who had trust in doctors were 75% more likely to prefer SDM (aOR 1.75, 95% CI 1.10–2.77, P = 0.017), especially adults aged ≥50 years who were receiving continued care with a regular doctor (aOR 1.83, 95% CI 1.18–2.86, P = 0.007). Continuity of care was observed to value-add SDM by building trusting relationships, though it was often absent in younger populations.

Conclusion

This study highlights the long-term value-add of building on cultural capital pertaining to appropriate antibiotic use and AMR, by leveraging on the role of trust in doctors, desire for SDM and anchoring these in continuity of care when possible.

Recommendations

Using focused messaging and exploring alternative channels of communications such as annual check-ins or tele-consultations with a regular doctor, and emphasizing continuity of care across all age groups would help bridge the identified gaps.
Predicting the behavioral intentions of hospice and palliative care providers from real-world data using supervised learning: A cross-sectional survey study
Authors: Chu Tianshu , Zhang Huiwen , Xu Yifan , Teng Xiaohan , Jing Limei
Published: September 2022

Background

Hospice and palliative care (HPC) aims to improve end-of-life quality and has received much more attention through the lens of an aging population in the midst of the coronavirus disease pandemic. However, several barriers remain in China due to a lack of professional HPC providers with positive behavioral intentions. Therefore, we conducted an original study introducing machine learning to explore individual behavioral intentions and detect factors of enablers of, and barriers to, excavating potential human resources and improving HPC accessibility.

Methods

A cross-sectional study was designed to investigate healthcare providers' behavioral intentions, knowledge, attitudes, and practices in hospice care (KAPHC) with an indigenized KAPHC scale. Binary Logistic Regression and Random Forest Classifier (RFC) were performed to model impacting and predict individual behavioral intentions.

Results

The RFC showed high sensitivity (accuracy = 0.75; F1 score = 0.84; recall = 0.94). Attitude could directly or indirectly improve work enthusiasm and is the most efficient approach to reveal behavioral intentions. Continuous practice could also improve individual confidence and willingness to provide HPC. In addition, scientific knowledge and related skills were the foundation of implementing HPC.

Conclusion

Individual behavioral intention is crucial for improving HPC accessibility, particularly at the initial stage. A well-trained RFC can help estimate individual behavioral intentions to organize a productive team and promote additional policies.
Do non-citizens migrate for welfare benefits? Evidence from the Affordable Care Act Medicaid expansion
Authors: Guo Hao , Zou Miaomiao
Published: September 2022

We explore if low-educated noncitizens, who have a considerably high uninsured rate, internally migrate to states with more generous public insurance benefits. We utilize the state-level variation in accessing Medicaid benefits and employ a difference-in-differences methodology that compares in-migration and out-migration rates of non-citizens in states that adopted Medicaid expansion, both before and after the policy implementation, to the outcomes of non-citizens in states that did not adopt the expansion. We find that interstate in-migration (out-migration) rates of Medicaid expansion states did not increase (decrease) relative to that of non-expansion states after the expansion.
Towards safety4.0: A novel approach for flexible human-robot-interaction based on safety-related dynamic finite-state machine with multilayer operation modes
Authors: Bdiwi Mohamad , Al Naser Ibrahim , Halim Jayanto , Bauer Sophie , Eichler Paul , Ihlenfeldt Steffen
Published: September 2022

In the era of Industry 4.0 and agile manufacturing, the conventional methodologies for risk assessment, risk reduction, and safety procedures may not fulfill the End-User requirements, especially the SMEs with their product diversity and changeable production lines and processes. This work proposes a novel approach for planning and implementing safe and flexible Human-Robot-Interaction (HRI) workspaces using multilayer HRI operation modes. The collaborative operation modes are grouped in different clusters and categorized at various levels systematically. In addition to that, this work proposes a safety-related finite-state machine for describing the transitions between these modes dynamically and properly. The proposed approach is integrated into a new dynamic risk assessment tool as a promising solution toward a new safety horizon in line with industry 4.0.
Knowledgeable, aware / interested: Young black women's perceptions of pre-exposure prophylaxis
Authors: Haider Sadia , Friedman Eleanor E. , Ott Emily , Moore Amy , Pandiani Agustina , Desmarais Catherine , Johnson Amy K.
Published: September 2022

Purpose

HIV in the United States disproportionately affects young Black women. Pre-exposure prophylaxis (PrEP) is an effective HIV prevention option that has the potential to reduce HIV incidence among HIV-vulnerable populations. However, data regarding women's awareness, interest in starting, and feelings of acceptability or stigma about PrEP remains limited, particularly among adolescent and young Black women.

Materials and methods

A cross-sectional survey was conducted with 100 sexually active young Black women ages 13–24 years attending women's health clinics in Chicago, IL. Descriptive statistics were used to characterize the sample and determine more about what the PrEP needs and barriers are in this community. Associations were modeled using logistic regression and 95% confidence intervals for both bivariate and multivariable models.

Results

In our survey (N = 100), half of study participants (50%) expressed interest in starting PrEP in the next three months and a majority (80%) of young women were confident they could obtain PrEP. Pregnant young women were significantly more interested in starting PrEP than non-pregnant women [OR 2.3 95% CI (1.0, 5.4)], p = 0.05), however, this association did not remain significant in adjusted models.

Conclusions

This study provides a more complete understanding of awareness, interest in, and acceptability of PrEP among adolescent and young Black women attending women's health clinics. Findings indicate sustained interest in starting PrEP, reduced stigma, and increased awareness of PrEP among young Black women. These findings suggest that integrating PrEP into women's health clinics is a promising strategy to increase awareness and utilization of PrEP and decrease HIV transmission among youth at highest risk.
Feasibility of leveraging menstrual cycle tracking apps for preconception research recruitment
Authors: Jukic Anne Marie Z. , Jahnke Hannah R. , MacNell Nathaniel , Bradley Danielle , Malloy Shannon M. , Baird Donna D.
Published: September 2022

Background

Mobile applications (apps) present a new opportunity to study menstrual cycles and time to pregnancy. Understanding the characteristics of cycle tracking app users is important to evaluate the feasibility of recruiting participants for preconception research.

Methods

Users of a cycle tracking smartphone app, Ovia Fertility, aged 18 or older in the U.S. were randomly invited via email to complete a “fertility research” questionnaire that included demographic and reproductive characteristics. Among those attempting pregnancy without medical assistance, attempt duration, factors influencing pregnancy planning, health history and behaviors while attempting to conceive were queried. Respondents could choose to enter a raffle for a $50 gift card.

Results

Initially, 639 people responded to the demographics portion of the survey representing 49 states and Washington DC. Of these, 344 (54%) were trying to conceive and of those, 297 (86%) were not using medical treatments. Of those not trying to conceive, 12% reported that they planned to start in the next 3 months. Most participants were ages 26–35 (63%), of White race (70%), reported non-Hispanic ethnicity (87%), had at least a bachelor's degree (56%) and an income between $50,000 and $200,000 (58%). One-third were of recommended BMI (35%), 24% overweight, and 41% obese. Most participants reported no fertility-related health conditions (58%). Forty-eight participants (17%) had been trying to conceive for 1 month or less, 88 (31%) had been trying for 2 months or less, and 122 (43%) for 3 months or less. Interruptions in pregnancy attempts were common, 31% reported periods without intercourse. Of those attempting pregnancy, 47% of partners completed their own questionnaire.

Conclusion

This first-of its-kind analysis describes users of a cycle-tracking smartphone app who could be eligible for recruitment to a prospective time-to-pregnancy study. Survey respondents were diverse with respect to geographic location, BMI, and income. However, special recruitment efforts will be needed to recruit participants and partners who identify as other than non-Hispanic White. Participants with fertility-related conditions are not overly represented among app users who are trying to conceive. Targeting and pre-enrolling app users who are planning to begin a pregnancy attempt in the next 3 months may be an advantage of app-based recruitment.
Capturing the holistic profile of high performance Olympic weightlifting development
Authors: Anderson Dior N. Jnr , Gottwald Victoria Mary , Lawrence Gavin Peter
Published: September 2022

Recent expertise development studies have used retrospective recall methods to explore developmental biographies and/or practice histories of current or past athletes. This methodological approach limits the generalizability and trustworthiness of findings. As such, a gap exists for research exploring key multidisciplinary features in athlete development using prospective longitudinal research designs. The present research aimed to holistically model the development of talent in Olympic Weightlifting using such a design. We observed the holistic profiles of 29 junior weightlifting athletes longitudinally over a 10-month period, and subsequently classified six of the 23 athletes as high performing based on their performances in competitions up to 12 months following the study. This holistic profile was based on a framework of expertise development themes: (1) demographics and family sport participation, (2) anthropometrics and physiological factors, (3) psychosocial profiling, (4) sport participation history, and (5) weightlifting specific practice activities. A summary model was produced which selected a critical set of nine features that classified group membership with 91% average accuracy. Odds ratio calculations uncovered discriminating features in the holistic profiles of performance groups, from which empirically derived logical statements could inform the description of high-performance attainment.
Which perspectives for work in agriculture? Food for thought for a research agenda
Authors: Dedieu Benoît , Nettle Ruth , Schiavi Sandra Mara de Alencar , Sraïri Mohamed Taher , Malanski Priscila Duarte
Published: September 2022

The 2nd International Symposium on Work in Agriculture (March 29–April 1 2021) was a moment for debate on the perspectives of work in agriculture. In this article, we propose to summarize the exchanges that outline the major issues from this event. We made a bibliometric analysis of all the contributions presented and a cross-cutting expert synthesis. Agricultural work and drivers of employment were the main topics of the presentations, with North and Global South countries facing different labor productivity dynamics. Some questions are continent specific: will OECD countries see agriculture without farmers? Will agriculture provide decent work to youth, notably in the Sub-Saharan Africa? With which models of agriculture? Some issues are common globally: the ability of the agroecological transition to improve working conditions and provide new jobs; the recognition of women and ethnic groups' contributions to work and to decisions. The digital revolution and the migration flows to and from rural areas and cities are also changing agricultural work substantially. Cross-cutting perspectives are introduced such as the potential of the decent work concept to foster the attractiveness of the agricultural professions, the effect of value chains and the potential of the territorial approach to work to foster interdisciplinary and transdisciplinary viewpoints in addressing problems in the domain.
Factors influencing the development of bone starvation syndrome after total parathyroidectomy in patients with renal hyperparathyroidism
Authors: Peng Xuyang , Xia Xiaofang , Li Zhouting , Cheng Feng , Zhu Xi
Published: September 2022

Purpose

To investigate the factors affecting the development of bone starvation syndrome (HBS) after total parathyroidectomy in patients with renal hyperparathyroidism (SHPT).

Patients and methods

The clinical data and perioperative indices of 141 patients who underwent PTX for SHPT were retrospectively analyzed. The patients were divided into HBS and non-HBS groups based on postoperative minimum blood calcium <1.87 mmol/L. The differences in general clinical data and perioperative related indices between the two groups were compared; logistic regression analysis was performed to analyze the risk factors influencing HBS occurrence after surgery. Multiple linear regression method was used to analyze the factors influencing the maintenance time of intravenous calcium supplementation and total amount of calcium supplementation during intravenous calcium supplementation. The threshold value for the diagnosis of HBS was analyzed using the ROC subjects' working curve.

Results

HBS occurred in 46 (32.6%) patients. Univariate analysis showed statistically significant differences in dialysis age, preoperative calcitonin, preoperative parathyroid hormone, preoperative blood phosphorus, and preoperative alkaline phosphatase between both groups (P < 0.05). Logistic regression analysis using stepwise entry method concluded that preoperative alkaline phosphatase was an independent factor for the development of HBS after surgery. Preoperative parathyroid hormone was an independent factor for the duration of intravenous calcium supplementation and total calcium supplementation during intravenous calcium supplementation in the HBS group. Based on the ROC curve, for postoperative HBS, the cut-off ALP value was 199.5 U/L, with a sensitivity of 80.85% and specificity of 82.61%.

Conclusion

Preoperative serum ALP may be an independent factor for HBS occurrence after surgery. When preoperative ALP > 199.5 U/L, patients with SHPT are prone to HBS after surgery, and the higher the preoperative ALP, the higher the incidence of HBS, and vice versa. In addition, preoperative PTH may be the factor in the timing of postoperative intravenous calcium supplementation and the total amount of calcium supplementation during intravenous calcium supplementation in patients with HBS.