bluuebunny/crossref_metadata_2025 huggingface dataset:
Primary screening of indigenous antagonist bacteria against Meloidogyne hapla larvae
Authors: Nekoval S. N. , Chernyakovich M. N. , Muraviev V. S. , Churikova A. K.
Published: January 2025

Aim. To determine the nematicidal activity of native bacterial isolates from the rhizosphere of tomatoes affected by the northern root‐knot nematode Meloidogyne hapla.The study was carried out using bacterial isolates obtained from the rhizosphere of a tomato affected by meloidogynosis, the species of which was determined using DNA nucleotide sequence analysis. The analysis was carried out on a DNeasy Plant Mini Kit and the results were compared using the Unipro UGENE program. Nematicidal activity was calculated based on the number of dead nematodes counted using a microscope.From the rhizosphere of tomatoes infected with the northern root‐knot nematode Meloidogyne hapla, 10 isolates of antagonist bacteria were isolated into a pure culture and identified. To consider their safety for humans and warm‐blooded animals, 7 of these were tested for nematicidal activity. According to the data obtained, the use of 5 studied bacterial strains caused mass mortality of northern root‐knot nematode larvae, starting from 24 hours and reaching 92.2–97.2 % by 96 hours after the start of the experiment.Bacterial strains Bacillus thuringiensis IB17 (titer 1x105, CFU/ml), Pseudomonas silesiensis IB18 (titer 1x106, CFU/ml), Bacillus mycoides IB19 (titer 1x108, CFU/ml), Glutamicibacter arilaitensis IB23 (titer 1x106, CFU/ml), Pseudomonas silesiensis IB24 (titer 1x107, CFU/ml) exhibits high nematicidal activity against M. hapla larvae and can be used to create bionematicides.
Promotion of environmental knowledge as a condition for the formation of ecological culture
Authors: Komkova G. N. , Toguzaeva E. N. , Karamysheva M. S.
Published: January 2025

Aim. To study the importance of promoting environmental knowledge, to identify its role in the formation of environmental culture in modern Russian society and to analyse the main problems of regulating the process of formation of environmental culture as a new social necessity.In order to achieve the goal, scientific literature, regulations and law enforcement practice, theoretical system analysis, comparative legal method and general scientific methods were used.The state and non‐state sector should take measures to educate citizens in responsible environmental behavior by promoting environmental culture, introducing environmental education and forming a special environmentally‐oriented consumption model. Undeservedly, the process of forming an environmental culture is restricted exclusively to educational and educational purposes and, as a consequence there are gaps in the legal framework for regulating environmental education and the retraining of personnel.The significance of the formation of an environmental culture in the context of new public policy priorities is beyond doubt.Attention should be paid to  stimulating lawful, socially active behavior in the sphere of formation of environmental culture as a new social necessity. The expansion environmental education, the elimination of the declarative nature of environmental legislation regarding the training of specialists in the field of ensuring environmental safety, and the resolution of the issue of unifying requirements for heads of organizations and specialists in the field of environmental protection and environmental safety at the level of federal law are seen as necessary conditions. Propaganda reflected in the legal domain, should become an effective tool for increasing the environmental knowledge of the population and the creation of a high level of environmental culture.
New and little‐known species of gall midges (Diptera, Cecidomyiidae) and other gall‐formers in the fauna of Dagestan
Authors: Fedotova Z. A. , Nakhibasheva G. M. , Mukhtarova G. M. , Teymurov A. A. , Gasangadzhieva A. G.
Published: January 2025

Aim. To develop additional information about the diversity of gall‐forming insects in Dagestan, their distribution, trophic links and features of the formation of complexes of dominant species on common host plants.The materials were collected in the plains and mountains of Dagestan. Standard methods were used: plant inspection, search and mass collection of galls, wintering in laboratory conditions, breeding of imago and preparation of larval and imago slides.New and little‐known gall midges in the fauna of Dagestan (27 species from 16 genera) were identified: 1 species of lace bat (Hemiptera, Tingidae) and case‐bearer (Lepidoptera, Coleophoridae) and 2 species from 2 genera of gall wasps (Hymenoptera, Cynipidae) and mites (Acariformes, Eriophyidae) were identified. New Cecidomyiidae in the fauna of Dagestan were 25 species of 13 genera, of them 5 species of 5 genera were new in Russia: Asphondylia ziziphorae Fedotova, 1985, Contarinia perplicata Fedotova, 1997, Mycodiplosis glycyrrhizae Fedotova, 1985, Izeniola potanini (Fedotova, 1982) и Jaapiella inulicola Fedotova, 1993; 4 species were new for the Caucasus: Placochela nigripes (Löw, 1877), Arthrocnodax galiobiae Fedotova, 1997, Jaapiella volgensis Fedotova, 2008 and Macrolabis luceti Kieffer, 1899. Other gall‐formers include the mite Aceria galiobia (Canestrini, 1891), the case‐bearer Auagasma atraphaxidellum Kuznetsov, 1957, the gall wasps Aulacidea hieracii (Bouché, 1834) and Diastrophus rubi (Bouché, 1834), all new for Dagestan. Gall‐formers (33 species from 22 genera) were identified on plants of 28 species from 25 genera and 13 families, of which 5 species from 5 genera, including endemics of the Caucasus, are new host plants for gall midges and other gall‐forming plants.Information about the complexes of gall‐formers of Dagestan and their common plants is relevant for solving the problems of taxonomy, associated phylogeny and study of the evolutionary features of gall formation. Due to the poor study of the fauna of gall‐formers, trophic links and distribution, their economic significance and prospects for use for phytosanitary control in the creation of protected areas, parks and the use of agricultural fields have not been sufficiently assessed.
Bacterial Composition of Soils in the Fatala River Basin (Guinea) during the Dry Season: An Examination of its Relationship with Ecological Landscape Characteristics
Authors: Ignateva D. A. , Gorbunova T. Yu. , Keita I. , Alekseev Ya. I. , Gorbunov R. V. , Shvartsev A. A. , Volkov A. A. , Monakhova Yu. A. , Tabunshchik V. A. , Diakité S. , Baldé A. M. , Sow M. D. , Diallo A. I.P.
Published: January 2025

This paper examines the bacterial composition of soils in the Fatala River basin, Republic of Guinea.This work is based on molecular genetic analysis.The research findings indicate that the most prevalent phyla are Proteobacteria, Firmicutes, Actinobacteria and Acidobacteria. Notable dominant species include Candidatus Koribacter versatilis and Candidatus Solibacter usitatus. In facies 11, particularly in a bauxite mining zone, there is an increase in cyanobacteria, potentially due to their capacity to enrich soil fertility. Alpha diversity peaks in facies 10, 12, 17 and 18 and bottoms out in facies 7. The decline in alpha diversity in facies 7 might be attributed to the increase in plankomycetes, which produce antimicrobial substances to outcompete other species. When examining beta diversity, facies 10, 12 and 17 show the highest similarity, while facies 3, 5, and 7 exhibit the most significant differences compared to all points analysed.The identification of the prevailing bacterial phylum and dominant species, along with specific taxa exhibiting increases or decreases in biodiversity, is a crucial first step in characterising the microbial communities found in the natural environments studied. The methodology established can be employed in environmental surveillance and evaluation of the health of diverse soil types.
Acute Neurological disorders in pregnancy and postpartum period – Systematic review
Authors: Kirovakov Zlatko , Hinkova Nadezhda , Dushepeev Antonio , Todorov Svetoslav
Published: January 2025

Objective: Stroke among young and elderly people is frequently caused by cervical artery dissection (CeAD). A rupture in any one or more blood vessel layers of tissue results in cervical artery detachment. Information for the causative factor of one-fifth of ischemic stroke patients is available from case reports and case reviews. CeAD is rare during pregnancy and in the early postpartum period. In addition, other risk factors have been suggested, such as infection, migraine, hyperhomocysteinaemia, and the 677TT genotype of the 5,10-methylenetetrahydrofolate reductase gene (MTHFR 677TT).
Limitation: A lack of neurological diseases during pregnancy and the postpartum period provides major obstacles for both the mother and child. The restricted therapeutic choices might impair care and complicate management. Multidisciplinary care is frequently required to achieve a delicate equilibrium between the health of the mother and the risk of foetal hazards.
Method: This systematic review with a systematically registered protocol was the strategy to study the clinical presentation, management, and outcome of this situation. For inclusion, 40 studies were found through language-free searches on Google Scholar and PubМed.
Results: The key factors of the greatest incidence found were migraine, hyperlipidemia, connective tissue diseases, HELLP syndrome, preeclampsia or eclampsia, and the protracted second phase of labor. The most frequent complaint was a headache with soreness in the neck. Anticoagulant medication, anti-platelet agents, and endovascular procedures were among the acute medical interventions.
Conclusion: This research emphasizes the value of efficient, all-encompassing care and raised knowledge to optimize results in pregnant women.
The Role of Business Intelligence and Artificial Intelligence in Real-Time Decision Making
Authors: Ebule Amejuma Emmanuel
Published: January 2025

The fusion of Business Intelligence (BI) and Artificial Intelligence (AI) has revolutionized decision-making processes across diverse industries, transforming how organizations utilize data to achieve strategic objectives (Chen et al., 2012). By integrating BI, which focuses on data collection, organization, and visualization, with AI’s predictive and prescriptive capabilities, businesses can move beyond traditional analytics to dynamic, real-time decision-making. This article explores the transformative role of BI and AI, emphasizing their applications in business analytics and operational decision frameworks. AI-powered tools, such as machine learning algorithms and natural language processing (NLP), significantly enhance the capabilities of traditional BI systems, enabling organizations to derive actionable insights, streamline operations, and maintain a competitive edge (Davenport & Harris, 2007).
This study delves into key case studies that highlight the practical implementation of AI-driven BI systems in various industries. These include predictive analytics for forecasting market trends, automated customer segmentation through NLP, and prescriptive analytics for optimizing supply chain operations. Furthermore, the article examines emerging technologies, such as explainable AI (XAI) and edge computing, that are shaping the next generation of real-time decision-making systems. The discussion extends to the challenges and opportunities in integrating these technologies, such as ensuring data privacy, addressing skill gaps, and managing implementation costs. Through a comprehensive analysis, this study aims to provide a holistic understanding of the convergence of BI and AI in the modern business landscape (Sharda et al., 2020).
Rede de Atenção à Saúde Bucal do SUS: a compreensão de profissionais e usuários sobre sua organização
Authors: Silva Sobrinho Adriano Referino da , Rocha Fabrício Nogueira , Coelho Luiz Gutenberg de Miranda Toledo , Sette-de-Souza Pedro Henrique , Cartaxo Renata de Oliveira , Mauricio Herika de Arruda
Published: January 2025

Objetivo: Analisar a compreensão de usuários e profissionais sobre a organização da rede de atenção à saúde bucal municipal de Arcoverde-PE. Métodos: Estudo observacional descritivo do tipo seccional de abordagem quantitativa e caráter exploratório. A coleta de dados foi desenvolvida a partir da aplicação de questionários em unidades de saúde municipais envolvendo profissionais das Equipes de Saúde Bucal (Cirurgiões-Dentistas e Auxiliares de Saúde Bucal) e usuários que se encontravam em tratamento. Resultados: A maioria dos usuários (87%) relatou saber como conseguir vaga para tratamento, mas 73,7% não conhecia as unidades que ofertavam atendimento. Dentre os profissionais, 81,3% relatou saber como funciona o fluxo de referência e contrarreferência municipal. Tanto profissionais quanto usuários responsabilizaram os gestores pela organização da rede. Conclusão: Os resultados reforçam a necessidade de divulgação do processo organizacional da rede de atenção à saúde bucal, otimizando o acesso da população e o processo de trabalho dos profissionais.
Promoção do mosquito ou promoção da saúde? Uma análise das postagens do Facebook do Ministério da Saúde do Brasil
Authors: Oliveira Bruna Paes de , Oliveira-Costa Mariella Silva , Mendonça Ana Valéria Machado
Published: January 2025

A pesquisa analisa as postagens do Facebook do Ministério da Saúde, durante três anos consecutivos, no mês de dezembro (2015 - 2017). Além do tema das postagens, foram identificadas a presença ou ausência de imagem, a menção ao SUS, e o foco do post na responsabilização do usuário, do gestor ou do trabalhador. Com características comuns às campanhas do Ministério da Saúde, as postagens apresentaram o A. aegypti como vilão e inimigo público e utilizaram amplamente da linguagem bélica e da responsabilização da população. Indo contra a perspectiva de uma comunicação promotora de saúde, expressões que denotam luta e guerra são usadas para tentar alcançar e conquistar a mobilização social. Conclui-se que apesar de as redes sociais serem espaço estratégico de comunicação e promoção da saúde, a comunicação executada pelo gestor federal do SUS tem como foco de conteúdo a guerra ao mosquito e responsabilização das pessoas
GRUPO DE EDUCAÇÃO ALIMENTAR E NUTRICIONAL COMO FERRAMENTA DE CUIDADO PARA PACIENTES COM DOENÇAS CRÔNICAS NÃO TRANSMISSÍVEIS NA ATENÇÃO PRIMÁRIA À SAÚDE
Authors: Frazão Neri Vitor
Published: January 2025

O atual cenário epidemiológico é caracterizado pela alta prevalência de doenças crônicas não transmissíveis, sendo elas um dos maiores problemas de saúde pública no Brasil e no mundo. O tratamento dessas doenças envolve a alteração de hábitos de vida, incluindo-se a alimentação saudável e a prática de atividade física; porém, essa mudança é complexa e envolve diversos fatores. A literatura aponta as atividades de educação em saúde como forma de intervenção para a mudança de hábitos, pois contribui para a autonomia dos indivíduos. O objetivo deste trabalho é relatar a experiência de um nutricionista residente em Atenção Básica, inserido em uma equipe do Núcleo Ampliado de Saúde da Família em uma unidade básica de saúde, com um grupo de educação alimentar e nutricional. As atividades ocorreram no período de abril de 2018 até dezembro de 2019 e tiveram como base teórica o Guia Alimentar para a População Brasileira e o Instrutivo de Trabalho em Grupos para Ações de Alimentação e Nutrição na Atenção Básica, ambos do Ministério da Saúde. Observaram-se troca de saberes, geração de confiança e capacidade de realização de escolhas nutricionais saudáveis. Entre os usuários que conseguiram ter maior continuidade no grupo e que praticavam atividade física regularmente, houve redução do Índice de Massa Corporal e melhora no perfil glicêmico, lipídico e pressórico. Percebeu-se, com esses achados, a existência de um ambiente com grande potencial para trazer reflexão crítica a respeito do cotidiano da comunidade, sendo também um ótimo espaço terapêutico para pacientes com doenças crônicas e para a Promoção da Alimentação Adequada e Saudável.
BACHARELADO EM SAÚDE COLETIVA NO SUDESTE DO PARÁ
Authors: Cavalcanti Aline , De Oliveira Campos Aline Aparecida , Viana Campos Ana Cristina , Podalirio Borges de Almeida Carlos , Santos Cossolosso Emanuelle Helena , Piassi Dias Godói Isabella , Dias Lima Jedlicka Letícia , Da Silva Castro Priscila
Published: January 2025

A formação de bacharéis em saúde coletiva propõe um novo modo de organização do processo de trabalho em saúde. Enfatiza-se a promoção da saúde, a prevenção de riscos e agravos, a reorientação da assistência, e a melhoria da qualidade de vida, privilegiando mudanças nos modos de vida e nas relações entre os sujeitos sociais envolvidos no cuidado à saúde da população. O presente artigo relata a experiência de acompanhamento ocorrida em setembro de 2019, de egressos da primeira turma de graduação em Saúde Coletiva da Universidade Federal do Sul e Sudeste do Pará, em Marabá - Pará. Dentre os 11 egressos da primeira turma deste curso de bacharelado, apenas 5 responderam ao formulário de acompanhamento, resultando no seguinte perfil: 80% têm entre 22 e 25 anos de idade, 80% do gênero masculino, 60% pardos, 80% solteiros, 80% residem em Marabá; 20% exerciam atividade remunerada durante a graduação e nenhum está inserido na área de atuação do curso. Dos respondentes, 50% estão exercendo atualmente alguma atividade remunerada com carga horária igual ou superior a 40 horas semanais. Apesar dos egressos terem concluído o curso há menos de 12 meses, o fato de não estarem inseridos na área é preocupante, ainda que as oportunidades de regularização do curso em concursos públicos estejam avançando. É importante o acompanhamento dos egressos como função social da universidade, buscando assim, observar o seu percurso e também manter vínculo e interação com a comunidade.
Inteligência artificial, data centers e colonialismo digital: Impactos socioambientais e geopolíticos a partir do Sul Global
Authors: Guimarães Furtado Renato , Evangelista Cunha Simone
Published: January 2025

Apesar do imaginário que celebra a imaterialidade da Inteligência Artificial, sua indústria é inerentemente material, agravando a crise climática a partir do consumo de recursos naturais e da emissão de gases de efeito estufa. Assim, o presente artigo argumenta a favor da inclusão da dimensão ecológica no debate sobre soberania digital – a autonomia e independência de um país em seu desenvolvimento digital. Para tanto, discutimos a expansão de data centers entre 2013 e 2023 no Brasil. A partir de revisão bibliográfica e pesquisa documental, primeiramente examinamos como a indústria da IA contribui para o adensamento da crise climática, principalmente através dos data centers. No segundo tópico, analisamos essas infraestruturas e seus impactos no país, sobretudo no que se refere ao seu alto gasto de energia e consumo de água. Por fim, abordamos a questão da soberania digital em justaposição à problemática do colonialismo digital. Concluímos que, nos moldes atuais, a IA pode contribuir para aprofundar práticas colonialistas, sobretudo a partir da articulação entre discursos tecno-otimistas e a extração de recursos naturais. Portanto, faz-se urgente a construção de enquadramentos teóricos capazes de amparar políticas públicas de monitoramento dos impactos sociomateriais causados por governos e empresas estrangeiros sobre territórios e suas populações no Sul Global.
IA emocional e design capcioso: a questão da soberania para a subjetividade
Authors: Bruno Fernanda , Faltay Paulo , Lerner Alice , Strecker Helena
Published: January 2025

Este artigo aborda a questão da soberania digital não somente como questão política e econômica, mas no âmbito do sujeito e da subjetividade ou da relação humano-máquina. Focalizaremos dois domínios em que a questão da soberania do sujeito se coloca de forma mais explícita: os sistemas de IA voltados para a inferência automatizada de características emocionais e psicológicas e a incorporação de padrões obscuros de design herdados da economia comportamental na construção das plataformas. Nos dois casos, analisaremos as implicações para a questão da soberania do sujeito e para o debate sobre regulação da IA a partir da pergunta disparadora: que modalidade de soberania do sujeito poderia ser proposta em plataformas de IA? Discutimos como na tentativa de impor barreiras à manipulação ou à influência insidiosa sobre indivíduos e populações, os marcos regulatórios correm o risco de reivindicar, de um lado, um sujeito plenamente autônomo e livre de influências ou, de outro, um sujeito definitivamente vulnerável que precisa ser protegido. Apontamos como nenhum desses extremos se sustenta quando se trata de compreender como as subjetividades, os processos psicológicos e emocionais são interpelados em plataformas de IA. Concluímos, por fim, que nos ambientes digitais, plataformas e aplicações de IA visados nesse artigo, a soberania do sujeito ou da subjetividade não pode ser assegurada de modo definitivo no plano individual nem no plano jurídico. Ela é, antes, um problema sociotécnico e tecnopolítico coletivo a ser continuamente trabalhado e revisado.
Desafios para a Soberania Epistêmica no contexto de Plataformização da ciência: Por métricas soberanas entre assimetrias globais e assimetrias informacionais
Authors: De Oliveira Thaiane Moreira
Published: January 2025

A visibilidade e o acesso equitativo aos recursos científicos são pilares essenciais para o avanço da pesquisa global, no entanto, a realidade atual revela disparidades preocupantes. A forma como medimos a circulação da ciência do Mundo Majoritário tem mostrado assimetrias nos canais de disseminação científica dominados pelos oligopólios editoriais científicos. Enquanto isso, a crescente plataformização da ciência intensifica a dependência de canais digitais, excluindo ainda mais aqueles que carecem de acesso à tecnologia ou à infraestrutura digital adequada. A ausência de acesso às APIs para compreender a circulação da ciência do Sul Global no ambiente digital adiciona uma camada adicional de opacidade, dificultando a análise e a promoção da diversidade científica. Nesse contexto, a questão da soberania epistêmica e digital emergem como aspecto fundamental para pensar novas formas de métricas alternativas que não apenas denuncie, mas também ressalte características importantes que mostram a diversidade epistêmica da pesquisa do Sul Global. Este ensaio tem como objetivo debater este panorama desafiador sobre assimetrias globais informacionais que apontem caminhos para superar essas barreiras estruturais e promover uma ciência verdadeiramente inclusiva, colaborativa e soberana.
Fiches de reconnaissance pratique des arbres sur pied en forêt Guyanaise. Acacia franc, Gaïac de Cayenne, Kaïman-Oudou, Kobé, Kouatakaman
Authors: Thiel Jean
Published: January 2025

Pas de résumé
La 2ème session de la Conférence ministérielle pour une politique concertée de lutte contre la désertification et de Protection de la Nature. COMIDES II
Authors: Laurent D.
Published: January 2025

Pas de résumé
Comment prendre en compte les mobilités saisonnières du bétail dans l’estimation de la charge animale d’un territoire sud-sahélien ?
Authors: Yakoubou Alzouma Yanoussa , Hiernaux Pierre , Larwanou Mahamane , Kaire Maguette , Garba Issa , Adamou Kalilou Amadou , Bode Sambo , Abdou Moussa Mahaman Maaouia , Abdou Bawa Harouna
Published: January 2025

Contexte : Au Sahel, les statistiques sur le cheptel d’un territoire administratif sont imprécises car elles sont basées sur des recensements par sondage, souvent anciens et actualisés par des coefficients de croît appliqués à l’échelle nationale. Objectif : Notre étude visait à quantifier le cheptel présent au cours d’un cycle annuel sur le territoire de Dantchandou au Niger afin d’estimer les besoins en fourrages, les impacts sur les ressources disponibles, les flux de matière organique et les émissions de méthane entérique. Méthodes : Le cheptel communal a été dénombré sur une année par espèce, sexe et classe d’âge. Le cheptel des 1 556 familles d’agro-éleveurs et agropasteurs sédentaires a été systématiquement recensé dans 40 points d’abreuvements. Une enquête exhaustive, menée dans 6 des 40 villages de la commune, a recensé le cheptel des 1 515 familles d’agriculteurs possédant quelques têtes de bétail. Les effectifs ont été extrapolés aux 3 983 familles d’agriculteurs des 34 autres villages. Les troupeaux des 45 pasteurs étrangers qui séjournent temporairement dans la commune ont été décomptés exhaustivement. Les flux saisonniers hors de la commune d’une partie des troupeaux des agropasteurs ont été quantifiés pour établir les charges mensuelles sur la commune. Résultats : le cheptel du territoire était composé de 22 028 bovins, 19 597 caprins et 22 374 ovins auxquels s’ajoutent ceux des pasteurs étrangers. Les mesures de poids vifs saisonniers ont permis d’exprimer cette charge en unité de bétail tropical, à savoir 0,38, 0,28 et 0,23UBT/ha en saison des pluies, en saison sèche et fraîche et en saison chaude respectivement. Les poids métaboliques ont permis d’estimer les besoins fourragers : 231, 172 et 139 kg MS/ha en saison des pluies, saison sèche et fraîche et en saison chaude respectivement. Conclusions : les estimations des besoins fourragers saisonniers seront confrontées à celles d’ingestion fourragère faites à partir de l’analyse des échantillons de fèces prélevés selon les saisons.
Prognostı̇k Nutrı̇syonel İndeks Juvenil İdı̇yopatı̇k Artrı̇tte Prognostik Biyobelirteç Olabilir Mi?
Authors: Sunar Yayla Emine Nur , Arslanoğlu Aydın Elif , Demirbaş Bahar , Yılmazer Yönder Ezgi , Bağlan Esra , Özdel Semanur
Published: January 2025

Bu çalışma, jüvenil idiyopatik artrit (JİA) hastalarında hastalık aktivitesi ile prognostik nutrisyonel indeks (PNI) arasındaki ilişkiyi incelemeyi amaçlamaktadır. Ayrıca, PNI’nın JİA’da prognostik bir biyobelirteç olarak kullanılabilirliğini değerlendirmek hedeflenmiştir. Oligoartiküler ve poliartiküler JİA tanısı alan hastalar, Jüvenil Artrit Hastalık Aktivite Skoru (JADAS) ölçümüne göre remisyon ve düşük hastalık aktivitesine sahip olanlar ile orta ve yüksek hastalık aktivitesi gösterenler olmak üzere iki gruba ayrıldı. İki grup arasında demografik, klinik ve laboratuvar özellikler ile PNI değerleri karşılaştırıldı. Çalışmaya, oligoartiküler ve poliartiküler JİA tanılı 106 hasta dahil edildi. Hastaların ortanca yaşı 5,95 yıl olup, 67’si (%63,2) kızdır. Üveit 18 hastada (%17), aile öyküsü ise 14 hastada (%13,2) gözlenmiştir. Hastaların üçte ikisi (n=69) oligoartiküler, %33,1’i (n=35) poliartiküler JİA tanısına sahiptir. On ikinci ay JADAS skoruna göre, remisyon/düşük hastalık aktivitesindeki hastalar (Grup 1) ile orta/yüksek hastalık aktivitesindeki hastalar (Grup 2) olarak iki grup oluşturulmuştur. Grup 1’de 52 hastaya (%58,4), grup 2’de ise 16 hastaya (%94,1) kortikosteroid tedavisi uygulanmıştır. Biyolojik DMARD kullanımı ise grup 2’de anlamlı derecede yüksektir ve en sık tercih edilen ajan etanersepttir. Hastaların 9’unda (%11,4) biyolojik DMARD değişikliği yapılırken, 15’inde (%14,2) tedavisiz remisyon sağlanmıştır. Ortanca PNI değeri gruplar arasında anlamlı fark göstermemiştir. PNI, JİA’lı hastalarda hastalık aktivitesini yansıtmakta yetersiz kalmaktadır ve prognoz tahmininde kullanışsız bir parametredir.
Application of multi-omics in hepatocellular carcinoma: new prospects for classification and precise diagnosis and treatment
Authors: He Jiaxue , Hu Xintong , Chen Liguo , Jiang Yanfang
Published: January 2025

Hepatocellular carcinoma (HCC) represents a significant global health challenge, with a complex etiology and limited treatment options. The integration of multi-omics technologies, including genomics, transcriptomics, proteomics, and metabolomics, has revolutionized our understanding of HCC, offering novel insights into its molecular underpinnings. This comprehensive review synthesizes the current knowledge on the application of multi-omics in HCC, highlighting its role in disease classification, early detection, and the development of targeted therapies. We discuss the identification of key driver mutations and single nucleotide polymorphisms (SNPs) that enhance risk prediction models, with implications for personalized medicine. The multi-omics approach has facilitated the discovery of distinct HCC subtypes, each with unique molecular signatures and tumor microenvironments (TME), which are critical for predicting prognosis and guiding treatment strategies. Furthermore, we explore the implications of these findings for precision medicine, emphasizing the potential of biomarker identification and targeted therapies, including immune checkpoint blockade (ICB). The review concludes by underscoring the transformative impact of multi-omics on HCC research and clinical practice, heralding a new era of personalized medicine with the promise of improved patient outcomes.
Energy study for the rehabilitation of the old Abbey of Salas de Bureba (Burgos) for residential use. Case study
Authors: Briones-Llorente Raul , Hidalgo-Betanzos Juan Maria , Montoya-Saiz Paula , Ruiz-de-Vergara-Ruiz-de-Azúa Imanol , Rubio-Pérez Gabriel , Muñoz-Rujas Natalia , Aguilar-Romero Fernando
Published: January 2025

The renovation of buildings is key to the fight against climate change and offers opportunities to fix the population in rural areas, revalue their heritage and help decongest cities. In addition, it has a lower environmental impact than new construction. With this contribution, the energy study for the rehabilitation of the old Abbey of Salas de Bureba, located in the Caderechas Valley, north of Burgos, is presented. The aim is to return the building to its original state, so most of the facades will not be able to be insulated. A detailed energy simulation has been conducted and all viable options have been analysed, applying passive improvements combined with the installation of renewable energies. This project, whose implementation has already begun, has obtained a double A energy rating, which has allowed it to apply for aid from the PREE 5000 Programme.
Comunicação não-violenta, cultura de paz nas escolas e a formação continuada de professores
Authors: Nascimento Franc Lane Sousa Carvalho do , Silva Leysiane Gomes de Oliveira
Published: January 2025

Neste estudo partimos do seguinte problema: de que forma a violência tem sido tratada pelas escolas e profissionais que nelas atuam? objetivo geral: analisar as práticas pedagógicas diante do fenômeno da violência na escola, em vista de ações colaborativas e formação continuada de professores que culminem em uma cultura mais pacífica, melhorando a qualidade dos processos educativos. Seguimos os princípios da abordagem qualitativa de caráter exploratório através do método dialético, realizamos as técnicas da entrevista semiestruturada e observação participante. Assim, pudemos inferir que a violência na escola é um fenômeno real, crescente e urgente, o qual carece de interferências por meio do poder público, assim como através de novas práticas pedagógicas voltadas para uma Cultura de Paz. Diante disso, se faz necessário que formações em exercício sejam realizadas mediante a demanda surgida nas escolas, com a intenção de coletivamente, fomentar reflexões acerca da violência.
A formação de condutas empreendedoras nas ECIT paraibanas: uma leitura discursiva dos documentos orientadores
Authors: Lima Neto Izaías Serafim de , Silva Francisco Vieira da
Published: January 2025

O artigo objetiva analisar o funcionamento do discurso do empreendedorismo dentro do Modelo das Escolas Cidadãs Integrais Técnicas (ECIT) da Paraíba. Para isso, realizamos uma investigação bibliográfica documental de orientação interpretativo-descritiva nos documentos Caderno de Disciplinas Empreendedoras (SEECT-PB,2021a) e Caderno Currículo por Competências e Habilidades: caminhos para a integração entre a formação básica e a educação profissional e técnica (SEECT-PB, 2021b). O método de investigação é a arqueogenealogia dos discursos pensada a partir das elucubrações do filósofo francês Michel Foucault. Flagra-se, nos enunciados analisados, a pungente incursão neoliberal dos modelos educacionais brasileiros, a partir dos quais se visa formar uma massa de estudantes que são capturados na lógica mercadológica do empreendedorismo, da formação continuada e da autorresponsabilização.
Analisis Strategi Pengembangan Usaha Lemon (Citrus Limon L.)
Authors: Safitri Rike Nur , Lumongga Dumasari , Fathurrrohman Yusuf Enril , Watemin Watemin
Published: January 2025

Lemon merupakan salah satu komoditi holtikultura yang memiliki potensial dan memperolehkan prioritas untuk dikembangkan saat ini. Tujuan dari penelitian ini adalah untuk mengidentifikasi serta menganalisis faktor internal dan faktor eksternal, perumusan alternatif strategi, dan penentuan prioritas strategi yang dapat dilakukan dalam strategi pengembangan usaha lemon (Citrus Limon L.). Metode analisis data yang digunakan oleh peneliti adalah analisis matriks IFE, EFE, IE, SWOT dan QSPM. Berdasarkan hasil penelitian diperoleh 12 faktor internal dan 12 faktor eksternal dalam usaha lemon PT XYZ. Pada matriks IE hasil perbandingan total nilai skor dari matriks IFE dan EFE menunjukkan bahwa posisi usaha lemon (Citrus Limon L.) berada pada sel V dengan nilai koordinat 2,42608;2,71945. Melihat posisi usaha lemon (Citrus Limon L.) PT XYZ dihasilkan 6 alternatif strategi pada matriks SWOT yang dapat dilakukan sebagai langkah dalam pengembangan usaha lemon (Citrus Limon L.). Hasil analisis QSPM menunjukan terdapat 3 strategi yang menjadi prioritas dalam pengembangan usaha lemon (Citrus Limon L.) yaitu: 1) Melakukan pengembangan produk dan penawaran produk ke bisnis/konsumen baru; 2) Mengembangkan pemasaran produk dengan mempertahankan harga jual ekonomis kepada konsumen; 3) Memperluas ruang lingkup penetrasi pasar melalui kerjasama dengan instansi pemerintah, perusahaan lain, dan usaha kuliner berbahan baku lemon.
Kata Kunci : lemon; strategi pengembangan; SWOT; QSPM.
Pengembangan Learning Object “Interaktivitas Pembelajaran Daring” Berdasarkan The First Principles of Instruction Untuk Mata Kuliah Designing E-Learning
Authors: Amalia Dinda , Ariani Diana , Anis Chaeruman Uwes
Published: January 2025

Penelitian pengembangan ini bertujuan untuk mengembangkan learning object “Interaktivitas Pembelajaran Daring” berdasarkan The First Principles of Instruction untuk mata kuliah Designing E-learning. Sasaran utama dari produk yang dikembangkan adalah mahasiswa Program Studi Teknologi Pendidikan UNJ. Penelitian pengembangan ini dilakukan dengan model pengembangan Integrative Learning Design Framework (ILDF) yang terdiri dari tiga tahapan, yaitu informed exploration, enactment, dan evaluation. Pengembangan ini juga melibatkan tiga ahli, yaitu ahli materi, ahli media, dan ahli desain pembelajaran. Selain itu, penelitian pengembangan ini telah melalui serangkaian uji coba pengguna, mulai dari uji coba one-to-one dengan 3 orang mahasiswa, uji coba small group melibatkan 9 orang mahasiswa, dan field test dengan menggunakan Skala Likert yang melibatkan 17 orang mahasiswa. Nilai rata-rata yang didapat pada tahap uji coba lapangan sebesar 4,45 dengan kategori sangat baik. Hasil penelitian ini menunjukkan bahwa produk learning object yang dihasilkan telah mencapai tingkat kualitas yang baik dan layak digunakan untuk memfasilitasi materi Interaktivitas Pembelajaran Daring pada mata kuliah Designing E-Learning.
Gamifikasi Pembelajaran dan Pengaruhnya Terhadap Motivasi Belajar Mahasiswa
Authors: Muhamad Iqbal Zea Ul Haque  , Muhammad Azhar Fachrezi  , Angga Hadiapurwa
Published: January 2025

Perkembangan pembelajaran pada era saat ini sangat membutuh teknologi, terutama teknologi digital. Salah satu penerapan dari produk teknologi digital dalam pembelajaran adalah dengan memanfaatkan game edukasi sebagai media pembelajaran. Game edukasi yaitu salah satu bentuk game yang ditujukan sebagai media pembelajaran, sarana latihan, sarana dalam menambah pengetahuan, dan juga media untuk melatih sikap dan perilaku pemain. Rendahnya motivasi mahasiswa untuk belajar, menjadi alasan dikembangkannya game edukasi. Tujuan dari penelitian ini adalah untuk mengetahui seberapa jauh game edukasi dapat meningkatkan motivasi mahasiswa untuk belajar. Pendekatan yang digunakan pada penelitian ini menggunakan pendekatan kuantitatif. Hal ini dikarenakan permasalahan pada penelitian kali ini bersifat dominan terjadi di lapangan. Hasil percobaan menunjukan 65,8% menjawab setuju, 21,1% menjawab sangat setuju bahwa gamifikasi pembelajaran dapat memberikan efek positif terhadap hasil belajar responden, sedangkan 2,6 % menjawab sangat tidak setuju, 10,5% menjawab netral. kesimpulannya, mayoritas responden setuju bahwa gamifikasi pembelajaran memiliki pengaruh positif dalam capaian hasil belajar.
Functional Improvements by Controlled Suture Tension in Arthroscopic Rotator Cuff Repair
Authors: Imai Shinji
Published: January 2025

Background:

Although a certain degree of tension in bridging sutures is required for proper tendon healing following suture-bridge rotator cuff repair, excessive suture tension may be detrimental to tendon healing. This study aimed to investigate the effects of bridging suture tension on clinical outcomes and tendon healing. We hypothesized that fixed, low tension of the bridging sutures would improve the tendon healing rate and clinical outcomes compared with maximum manual tensioning.

Methods:

A group of 39 patients with a rotator cuff tear were treated with arthroscopic suture-bridge rotator cuff repair, in which the bridging sutures were uniformly tensioned to 20 N (group A). A separate group of 37 patients was treated with the same suture construct, but the sutures were tensioned by maximum manual pulling (mean tension, 36.1 N; group B). The visual analog scale (VAS) score for pain, active anterior elevation, external and internal rotation, and Constant score were compared between the groups preoperatively and at 1, 3, and 6 months and 1 and 2 years postoperatively. Anatomical healing was evaluated using magnetic resonance imaging (MRI) at 1 year after surgery.

Results:

At 6 months postoperatively, all clinical values had improved in both groups. The Constant score (p < 0.001), VAS pain score (p < 0.001), and anterior elevation (p = 0.004) were significantly better in group A than in group B. Two years postoperatively, there was no significant difference between groups A and B in the Constant score (p = 0.847), VAS pain score (p = 0.991), and anterior elevation (p = 0.855). Group A demonstrated a significantly lower retear rate (3 of 39, 7.7%) than group B (9 of 37, 24.3%) (p = 0.0467).

Conclusions:

Double-row suture-bridge repairs with fixed, low tension led to superior clinical outcomes at 6 months and a superior tendon healing rate at 1 year compared with repairs with higher suture tension. However, the clinical outcomes did not differ significantly at 2 years between the 2 tensioning methods.

Level of Evidence:

Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
The clinical and cost effectiveness of behavioural therapy for interepisode bipolar symptoms (STABILISE): A randomised, controlled feasibility trial.
Authors: Wright Kim , Warren Fiona C , Bucci Sandra , Dunn Barnaby , Jones Steven , O'Mahen Heather , Taylor Rod , Medina-Lara Antonieta
Published: January 2025

Background: In between episodes of (hypo) mania and major depression, people with bipolar disorder can experience ongoing low mood or mood instability, and these may also be present as part of cyclothymic disorder. This is a phase II evaluation of an adapted form of behavioural therapy (STABILISE) for inter-episode bipolar symptoms. The study aims to establish the feasibility and acceptability of the therapy and research procedures, including an economic component, to inform a future definitive trial.
Methods: Patients will be randomised 1:1 to either Treatment as Usual (control arm) or Treatment as Usual plus STABILISE intervention (intervention arm). Follow up points will be at 14, 30 and 52 weeks post eligibility confirmation, with 30 weeks as the primary end point. We aim to recruit 60 individuals meeting diagnostic criteria for a Bipolar Spectrum Disorder, and reporting ongoing bipolar symptoms (low mood or mood instability) outside of a manic or severe depressive episode. Feasibility and acceptability will be examined through recruitment and retention rates, completion rates for the candidate primary outcome measures (PHQ9, ALS-SF, QoL.BD and BRQ) and feedback from participants on their experience of study participation and therapy. Proceeding to a definitive trial will be indicated if the following criteria are met: i) trial participation is deemed, or can be made, sufficiently safe; ii) recruitment rate indicates that larger-scale recruitment would be feasible (recruitment rate of at least two participants per month within at least one site, with mitigation plan if overall target sample size not met); iii) for candidate primary outcome measure follow up data is available at 30 weeks from at least 75% of participants, or from between 55 and 74% with clear plan for improvement.
Discussion: This study is a randomised, controlled feasibility trial that builds on an initial case series of the STABILISE approach. The findings will be used to establish whether a future, definitive trial is feasible and to refine the research procedures and therapy protocol.
Trial Registration: ISRCTN18207465. Registered 13th March 2024, https://www.isrctn.com/ISRCTN18207465.
Protocol version: 1.2 30.8.24
A bright synthetic near-infrared luciferin enhances the capabilities of deep-tissue bioluminescence imaging using firefly luciferases
Authors: Kuchimaru Takahiro , Saito-Moriya Ryohei , Iwano Satoshi , Kitada Nobuo , Yamazaki Norihisa , Kamiya Genta , Ogo Katsunori , Sugiyama Takashi , Chuluun-Erdene Ariunbold , Isagawa Takayuki , Obata Rika , Ijuin Ryosuke , Abe Hideki , Yuji Kashiwakura , Mabuchi Yo , Takahashi Megumu , Yamamoto Yoshihiro , Sawaki Daigo , Sato Tatsuyuki , Sato Shigeru , Nishikii Hidekazu , Yoshimura Kotaro , Hioki Hiroyuki , Ohmori Tsukasa , Nakashiba Toshiaki , Hirano Takashi , Aoyama Hiroshi , Takeda Norihiko , Miyawaki Atsushi , Maki Shojiro A
Published: January 2025

Synthetic bioluminescence reactions exhibiting near-infrared (NIR)-shifted spectra have been explored to improve deep-tissue imaging through the design of firefly luciferin analogues. Although the NIR bioluminescence reactions improve the tissue penetration of bioluminescence signals from deep tissues, their photon output is markedly lower compared to the natural reaction with D-luciferin and firefly luciferase (Fluc), often by an order of magnitude or more. Consequently, in most instances, the sensitivity of NIR bioluminescence imaging (NIR-BLI) has not yet substantially surpassed that of BLI with the natural firefly reaction. Here, we present a synthetic firefly luciferin, named AkaSuke, that generates intense NIR bioluminescence (λmax = 680 nm) in reaction with Fluc, greatly improving the detection sensitivity beyond that of the D-luciferin/Fluc reaction for targeting deep tissue. AkaSuke enables sensitive visualizations of ectopic hematogenesis through entire tissues of mice over time following transplantation of bone marrow stem cells labeled with Fluc. We additionally identify a Japanese firefly luciferase, DkumLuc1, that displays higher catalytic activities for bioluminescence emission of AkaSuke compared to typical Fluc, resulting in detection sensitivity comparable to that of AkaLumine/Akaluc reaction, one of the most sensitive bioluminescence systems for deep tissue imaging. We further propose the potential of the AkaSuke/DkumLuc1 reaction as an orthogonal pair with the AkaLumine/Akaluc for sensitive dual-target tracking in mice. Overall results suggest that AkaSuke enhances the capabilities of deep-tissue bioluminescence imaging using Fluc and its variant, and could serve as an emerging benchmark for the molecular design of NIR luciferin analogues.
Balancing Standardization and Flexibility in National Complex Intervention Scale-Up: A Qualitative Study of Leadership Experiences and Management in the Implementation of Proactive Health Support (PaHS) in Denmark
Authors: Fredens Mia , Terkildsen Morten Deleuran , Grønkjær Mette , Toft Ulla , Hawkins Jemma , Nielsen Camilla Palmhøj
Published: January 2025

Background Policymakers increasingly aim to expand small-scale healthcare interventions to a national level to maximize reach and impact. However, scaling complex interventions presents challenges, particularly in balancing national standardization with flexibility in local implementation across contexts. This study investigates how leaders experience and manage the national implementation of Proactive Health Support, a large-scale self-management support intervention in Denmark.Methods The study employed a single-case study design with embedded units to examine the national implementation of the Proactive Health support intervention. Data were collected through 10 semi-structured interviews with leaders from the five Danish regions, more than 25 hours of participant observations of leadership meetings and workshops, and document analysis of 468 pages of leadership meeting minutes and reports.Results Implementing Proactive Health Support required leaders to balance the tension between fidelity and adaptation within a standardized framework. While the national framework provided stability, leaders leveraged the flexibility of implementation strategies to preserve the core intervention components while enabling local adjustments to fit diverse contexts. Reflexive practices—characterized by real-time adjustments and positive feedback loops—were pivotal for balancing standardization with flexibility. Vertical leadership mediated alignment between national and regional levels, while horizontal collaboration fostered shared learning across regions.Conclusion This study demonstrates the complexity of scaling healthcare interventions across diverse contexts, underscoring such processes' non-linear and dynamic nature and the significant ongoing, real-time leadership engagement required to navigate complexity and manage uncertainty. It highlights collaborative leadership as crucial for enabling real-time responsiveness, fostering alignment across levels, and balancing fidelity and adaptation in national implementations. The findings empirically demonstrate that fidelity and adaptation are not opposing forces but complementary in practice, with adaptation in implementation strategies supporting fidelity by allowing interventions to be applied meaningfully across diverse contexts. The findings further suggest that successful national implementation relies not on strict adherence to standardized guidelines but on a co-adaptive process within a standardized yet flexible framework, where intervention and context are co-constructed through ongoing, leadership-driven negotiation.Trial registration: The implementation was studied as part of a multidisciplinary research program. The study is a follow-on study to a randomized controlled trial (ClinicalTrials.gov, NCT03628469).