bluuebunny/crossref_metadata_2025 huggingface dataset:
İdeolojik Tarih Yazıcılığı Bağlamında İbnü’l-Kûtiyye’nin Târîhu iftitâhi’l-Endelüs Eserinin Değerlendirilmesi
Authors: Curuk Osman
Published: March 2024

İbnü’l-Kûtiyye tabakat kitaplarında farklı ilim dallarında yetişmiş bir âlim olarak tasvir edilmiştir, fakat o yazdığı Târîhu iftitâhi’l-Endelüs isimli eseri ve tarihçiliği ile ön plana çıkmıştır. Günümüze ulaşan eseri Endülüs tarihini konu edinen ilk kitaplar arasındadır. Eserinde III. Abdurrahman (300-350/912-961) dönemine kadar Endülüs tarihine dair olayları özet olarak ele almıştır. Kitabında ağırlıklı olarak siyasi olaylara yer verse de sosyal ve kültürel hayata dair bilgilere de yer vermiştir. İlerleyen süreçte eseri ve tarihçiliği hakkında birçok tartışma ortaya çıkmıştır. Bunların başında Târîhu iftitâhi’l-Endelüs’ün ona aidiyeti meselesi gelmektedir. Ayrıca Got asıllı olmasından dolayı Hristiyan kökenli müvelledûn konusundaki rivayetlerde ayrıcalıklı davrandığı iddia edilmiştir. Eseri hakkındaki bir diğer tartışmalı konu ise ailesinin Endülüs Emevîleri ile olan yakınlığı nedeniyle Emevî yanlısı ideolojik bir tarih anlayışı benimsediği hususudur. Tüm bu tartışmalara rağmen eser, İbnü’l-Kûtiyye’ye ile anılmış ve kendisinden sonra birçok önemli Endülüs tarihçisine kaynaklık etmiştir. Dolayısıyla Endülüs tarihine dair yazılan ilk eser olması; siyasi ve sosyal birçok konuya değinmesi bakımından oldukça önemli bir eser olma özelliğini korumaktadır.
Endodontic treatment or extraction: search for compromise
Authors:   Postgraduate Institute for Public Health Workers of the Ministry of Health of the Khabarovsk Krai, Khabarovsk, Russia, Ostroverkhova N.V.
Published: March 2024

The article, using the example of clinical cases from dental practice, analyzes the causes, symptoms and tactics of dental treatment in case of periapical inflammation, an algorithm of instrumental and drug treatment. A tooth caused an apical granuloma or cysts often has to be removed. The aim of endodontic treatment is the prolonged preservation of the tooth as a functional unit of the chewing apparatus, the restoration of the health of periapic tissues and the prevention of autoinfection and sensitization of the body
Hitit Dünyasında Çıplaklara Dair Bazı Gözlemler
Authors: KIRÇIL Zekiye Nihan
Published: March 2024

İnsanlık tarihinde daima kendini gösteren zaman zaman ise en büyük tabulardan bir tanesi sayılan çıplaklık, birçok toplumda ve kültürde farklı şekillerde işlenmiştir. Bazı kültür çevrelerinde çıplaklık oldukça doğal bir durum olsa da bu durum güzellik ve idealizm çerçevesinde değerlendirilmiştir. Kimi zaman ise bazı anlayışlarda çıplaklık ahlaksız ve utanç verici olarak kabul edilmiştir. M.Ö. 2.binyılda Anadolu’da siyasi hakimiyet kuran Hititlerin geride bıraktığı çiviyazılı metinlere bakıldığında, bu konunun işleniş biçimine dair çok çeşitli bilgiler olmasa da yine de çıplaklığa dair bazı somut örnekler görülmektedir. Çeşitli Hitit bayramlarında karşılaşılan ve doğal kabul edilen çıplaklık, Hititlerde ritüelistik bir eylem olarak kabul edilmiştir. İncelenen Hitit çiviyazılı metinlere göre çıplak olan görevliler şarkıcılar, dansçılar, ALAN.ZU9, köpek adamlar ve hapiya-adamlardır. Bu görevlilerden bazılarının çıplak performans sergilemesi kimi zaman insanları ve tanrıları güldürmek için bir eğlence biçimi olarak değerlendirilirken, çıplaklığın geçmişte önemli bir yere sahip olan avcılıkla ilgili olabileceğini de düşündürmektedir. Aynı zamanda Hitit dünyasında çıplaklık, bazen aşağılayıcı, küçük düşürücü durumları ifade etse de çıplak kimselerin giydirilmesiyle ilişkili olarak iyilik eyleminin vurgulandığı bazı durumlar da bulunmaktadır. Mitolojide ise olumsuz durumlardan korunmak adına bazen çıplak olan tanrıları giydirmek gerekirken bazen de çıplak tasvir edilen ve bolluk ile bereketi simgeleyen tanrıçaların çıplaklığı kötü kimseleri baştan çıkarmak adına araç olarak kullanılmıştır. Bugün hala tartışmalı bir konu olan çıplaklığın Hitit dünyasına nasıl yansıdığı ise bu çalışmada Hititçe çiviyazılı kaynaklar sayesinde irdelenmeye çalışılacaktır.
Karadeniz’in Kuzeyinde İskit Kurganlarında Bulunan Balta Örnekleri
Authors: KOÇAK Kürşat
Published: March 2024

İskitler hakkında kendi yazılı metinlerinin olmaması kökenleri hakkında pek çok tartışmayı günümüze kadar beraberinde getirmiştir. Özellikle ilk araştırmaları yapan Rus ilim adamları bu konuyu muğlakta olan kanıtlarla İrani kökene bağlamaya çalışmıştır. Ancak Türk ilim adamları ise yaşam biçimlerini Bozkır kültürüne bağlamışlar ve İskitlerin Türkistan (Orta Asya) kökenli oldukları fikrini öne sürmüşlerdir. Bu durumda ise Herodot’un İskitlerin kökeninin doğuya dayandığını belirten bilgileri etkili olmuştur. İskitlerin doğudan geldiği ve Bozkır kültürü dairesine ait olduğu kanaatini biz de taşımaktayız. Ancak İskitler doğudan batıya pek çok maddi kültür unsurları taşırken daha fazlasını da Ön Asya dünyasından almıştır. Özellikle Ön Asya ile Orta Asya arasında metal eşyaların taşınmasında aracılık etmiştir. Ön Asya’daki metal eritme teknolojisi de bu sayede doğuya taşınmış ve ileride metal aletlerin gelişim evriminde önemli rol oynamıştır. Orta Asya’da MÖ 5000’ler civarında taş ve kemik malzeme ile delici ve de kesici aletler imal edilirken MÖ 3000’lerde ise bakır eşya kullanılmaya başlanmıştır. Bakırın kalitesinin artırılması ile Tunç (Bronz) metalinin eşyalarda kullanımı önemli derecede artmıştır. Bozkır kültüründe bronz kullanımı çok yaygın olmasına rağmen bronzun karışımı olan kalayın zor bulunması sonucu demir kullanılmaya başlanmıştır. İskitler bronz üzerinde uzmanlaşmalarına rağmen demir kullanmışlar ve demirden pek çok alet edevat yapmışlardır. Bunlar arasında inceleyeceğimiz metal obje ise, baltadır. Özellikle Karadeniz’in Kuzeyindeki kurganlarda elde edilmiş birkaç balta örneğini ele alacağız.
Unraveling intestinal lumen formation in Caenorhabditis elegans
Authors:   , Sepers Johannes Jan
Published: March 2024

Most organs within our body are comprised of tubular structures essential for nutrient and waste transportation. Examples include blood vessels through which our blood flows, the intestines where we digest food, and airways through which air reaches our lungs. A crucial aspect of tube formation lies in the creation of a lumen, the central hollow space within the tube, which is orchestrated by a complex interplay of molecular players and cellular mechanisms. In this thesis, we employ cutting-edge genome engineering techniques and extensive microscopy analyses to delve into the molecular underpinnings of lumen formation, using the Caenorhabditis elegans intestine as a model system. Specifically, we focus on elucidating the roles of ERM proteins, NHERF proteins, and Ste20-like kinases in modulating the actin cytoskeleton to orchestrate lumen formation. ERM‑1, the sole C. elegans ERM ortholog, is essential for lumen formation, and disruptions in its membrane binding domain lead to widening of the intestinal lumen accompanied by constrictions. Furthermore, our research uncovers the nuanced regulatory role of ERM‑1's phosphorylation state at the C‑terminal T544 residue, which intricately modulates its stability and apical recruitment. In addition, ERM-1 activity involves actin binding modulated by this C-terminal phosphorylation and NRFL-1, with the latter being recruited to the microvilli by ERM-1, suggesting a vital role in organizing the apical domain. Moreover, our research identifies the GCK‑4 kinase as a novel regulator of lumen formation, localized at the tips of microvilli. Depletion of GCK‑4 results in a widened lumen, distorted adherent junctions, and alterations in the actin network, similar to defects observed in erm‑1 mutants. Interestingly, unlike its Ste20-like kinase counterparts, GCK‑4 is not a ERM C-terminal kinase, thereby contributing to lumen formation in a unique and yet-to-be-discovered manner. In addition to unraveling the molecular intricacies of lumen formation, we also improved the auxin-inducible degradation (AID) system in C. elegans by integrating a novel mIAA7 degron. This enhancement demonstrates significant efficacy in inducing protein degradation across various proteins and tissues compared to the conventional degron, thereby facilitating the study of specific proteins involved in lumen formation with enhanced precision and efficiency. By elucidating the intricate mechanisms underlying lumen formation through the lens of the C. elegans model organism, this work contributes to our understanding of fundamental biological processes and holds potential implications for the treatment of tube-related disorders.
Het bevorderen van familie- en mantelzorg in beleid en regelgeving
Authors:   , de Kievit Femke Marjolijn
Published: March 2024

In this doctoral research, Dutch policy and regulations on encouraging family care
have been mapped out and analyzed in order to identify room for improvement.
Family care is the intergenerational non-medical care provided by adult children
to their elderly parents who still live independently at home. Children do not
provide this care professionally. A more popular term for this type of care, is
‘informal care’, which includes caregiving within all social relations. Although
the focus of this research is family care, the information and findings are relevant
to all forms of informal caregiving. That is because policy and regulations do not
usually differentiate between social relations.

The starting point of this research, are changes in Dutch healthcare policy. Due to
the ageing population, the welfare state is facing financial and personnel
challenges. Cost containment has characterized the Dutch healthcare policy for
decades. To reach this goal, policy also aims at enabling individuals to live longer
at home with extramural care, and at increasing the responsibility of families and
the broader social network in caring for loved ones (the refamiliarization of care).
However, the increased emphasis on family responsibility, particularly that of
adult children, is not without challenges. The availability of children to provide
care is under pressure due to changing family structures. Families are smaller,
children and parents live further apart more often and there are more composite
households. Additionally, shifts in family dynamics, such as the increased labor
market participation of women, further contribute to the reduced availability of
children for caregiving. Alongside availability issues, family caregiving entails
risks, including overburdening (physical and/or mental health issues), financial
risks (income loss, reduced availability for the job market, and extra costs), and
conflicts within the family.

These developments raise a fundamental question that has been underexplored in
legal studies and is examined in this dissertation: What do Dutch policy and
regulations look like concerning the encouragement of family care, and how can
they be improved?

The encouragement of family care means: facilitating the availability of children
for care and protecting them from the aforementioned risks. The research has three
objectives: mapping out how the state addresses family care in policy and
regulations (within all areas of law), identifying areas for improvement through a
multidimensional analysis of policy, regulations, and practice, and exploring the
(possible) role of private law for family care.
Updates in BRAF V600E-Mutated Metastatic Colorectal Cancer
Authors: Scott Brigitte
Published: March 2024

Colorectal cancer (CRC) is the third most common cancer worldwide, and the second leading cause of cancer death. Approximately one in five patients with CRC present with metastatic disease at diagnosis. The BRAF V600E mutation occurs in 8–12% of patients with metastatic colorectal cancer (mCRC), and is characterised by an aggressive clinical course and poor prognosis. This article is based on a webinar discussion in March 2024, between two experts in gastrointestinal cancers, Chiara Cremolini, University of Pisa, Italy; and Julien Taieb, Georges Pompidou European Hospital, Université Paris-Cité, France, both of whom have a wealth of experience and expertise in the clinical management of CRC. The experts described the most important recent advances in the treatment of BRAF V600E-mutated mCRC, including data presented at the European Society for Medical Oncology (ESMO) Congress in October 2023, and the American Society of Clinical Oncology (ASCO) Gastrointestinal (GI) Cancers Symposium in January 2024. Cremolini and Taieb gave valuable insights into topics such as the aggressive nature of BRAF V600E-mutated mCRC, and how this impacts choice of treatment, patient outcomes, and quality of life, as well as the importance of early testing and monitoring. The experts also discussed how the BRAF V600E mutation impacts treatment response and outcomes in patients with microsatellite unstable (microsatellite instability [MSI]) versus microsatellite stable (MSS) tumours, and recent key clinical trials in BRAF V600E-mutated mCRC. The importance of surgery in the multidisciplinary management of patients with BRAF V600E-mutated mCRC, BRAF as a prognostic marker in resected CRC, and real-world studies in this field were also explored. Finally, Cremolini and Taieb described what the future of the management of patients with BRAF V600E-mutated mCRC might look like, and which advancements in research they would like to see.
CAR PARKING NEEDS ANALYSIS AT CAMPUS A, JAKARTA STATE UNIVERSITY IN THE CONSTRUCTION PERIOD
Authors: Puspa Wangi Intan , Lenggogeni Lenggogeni , Hadi Winoto
Published: March 2024

Parking is the main supporting facility in the campus environment. Jakarta State University (UNJ) is one of the state universities in the DKI Jakarta province. The increase in the number of UNJ students every year certainly causes an increase in the need for parking, especially on Campus A UNJ as the main campus. Coupled with a construction project in Campus A UNJ, the parking area, especially car parking, is getting narrower. Based on these problems, it is necessary to research parking arrangements at Campus A UNJ.
This study aims to determine the need for parking and arrange the car parking area for Campus A UNJ according to the demand for car parking space that existed during the construction period. The parking space arrangement for Campus A UNJ considers UNJ's policy as the manager in allocating parking spaces in the future. Primary data was obtained by conducting a field survey using the number plate survey method and PSU calculation survey while secondary data was obtained from UNJ parking inventory data. Primary data were obtained by conducting field surveys on 29 May-31 May and 8-9 June.
The results showed that the value of the need for car parking in 2023 was 367 PSU cars, while the number of parking lots available at Campus A UNJ was 389 PSU. The peak day occurs on Tuesday 30 May 2023 and the peak hour for parking accumulation occurs at 13.00-14.00 WIB. With a parking index close to 100%, this can make it difficult for drivers to find an empty parking space, especially considering the pattern of car parking in the UNJ campus A parking area rotates in one direction so that the opportunity to find an empty parking space during peak parking hours only has a one-time or one-time chance. parking spaces at peak parking hours only have a one-time chance or the driver must first exit the parking lot and then enter again to find an empty parking space. The arrangement of car parking modeling will also be presented in this article. It is hoped that the results of this early-stage research can provide an overview and recommendations on parking management methods at Campus A UNJ.
FACTORS CAUSING TIME DELAYS COMPLETION OF CONSTRUCTION PROJECTS(Case Study on Facilities Building Construction ProjectSports Stage 5 Construction of the East Stand)
Authors: Arif Al , Wibowo Kartono , Sumirin Sumirin , Ni'am Moh. Faiqun
Published: March 2024

Inaccuracy in planning project activities during project implementation greatly affects implementation delays in the field. The purpose of the study is to determine and analyze: (1) the causal factors that contribute to project completion delays, (2) the causal factors that contribute to the dominant delay in project completion, and (3) delay risk management. In the Sports facilities (Eastern Tribune Development) project. Cirebon Regency.
This study is a type of quantitative descriptive study. Data collection was done through FGD, interviews and questionnaires distributed to 10 qualified respondents in the construction sector. The resources of this study are the cause of the delay in the completion of the projects. A House of Risk (HOR) approach was used to analyze the data.
Research results show that (1) Cirebon Regency Sports Facilities Building (Eastern Tribune Development) project has 14 risk events and 17 identified risk causes that cause delays. (2) Control factors that cause delays in project completion include: material factors, contract document factors, project owner factors, and contractor and design consultant factors, and (3) delay risk management options, including: (a) good communication and coordination. with the owner; (b) apply a comprehensive planning approach to procurement of materials, (c) coordinate current project drawings between consultants and field workers, (d) contact consultants and supervisors.
Assessment of surface and groundwater quality in Tikamgarh
city, Madhya Pradesh, India
Authors: Narayan Gupta Laxmi , Arora Sameer , Kumar Ahirwar Mukesh , Prakash Pandey Amar , Bhushan Khare Anand , Shyam Gupta Ghan
Published: March 2024

Surface water and groundwater are primary resources for communities living in arid and semi-arid regions. The expansion of industrial and agricultural practices has raised pressure on natural resources. Water quality assessment provides valuable information about potential of resources for intended uses. The correlation study was carried out on the physicochemical parameters of surface water and groundwater in the Tikamgarh city. The physicochemical parameters, such as pH, total dissolved solids (TDS), total hardness (TH), calcium (Ca2+), magnesium (Mg2+), total alkalinity (TA), sulphate (SO42-), fluoride (F-), iron (Fe), nitrate (NO3-), chloride (Cl-) and turbidity were analysed to determine correlation between parameters. The grab sampling technique was adopted to collect water samples from selected dug wells and reservoirs. The results of physicochemical parameters were fitted in the correlation coefficient equation to predict probable values of different parameters for selected locations. Results of the correlation study showed that calcium and TH are strongly correlated, followed by TH with chloride. However, Ca2+, TH, Cl-, TA, TDS, SO42-, and iron show a high correlation. The findings show that water quality can be managed by controlling TH and TDS concentrations through conventional and non-conventional treatment methods.
Prevention of flash floods in the town of Kokrajhar
through efficient drainage network design
Authors: Basumatary Sagar , Swargiary Debshri , Hubballi Rajashekar
Published: March 2024

Flash floods are common in the town of Kokrajhar in north-eastern Indian state of Assam. Many areas in the town of Kokrajhar are submerged in water almost every year due to floods during rainy season. These floods cause heavy damage to roads, agricultural production and halt the progress of major infrastructural development projects. Hence, prevention of floods has become an important concern in the town of Kokrajhar. This study investigated the causes of floods and offered a solution for their elimination. The investigation showed that inadequate and inefficient network of storm drains was the reason for the flash floods. A new drainage network for the town of Kokrajhar has resulted from studying the shortcomings of the existing network of storm drains. The new network is designed in accordance with the recommendations stated in the “Manual on storm water drainage systems” prepared by the Central Public Health and Environmental Engineering Organization in 2019.
Hubungan Tingkat Stress dengan Kadar Gula Darah Pada Penderita Diabetes Melitus di Puskesmas Mulyorejo Surabaya
Authors: Rini Hamsidi  , Sumardiko Dwi Setiani , Adianti Myrna , Septriana Maya , Puruhito Edith Frederika , Imandiri Ario
Published: March 2024

One of the generative diseases today increasing in numbers worldwide is diabetes mellitus (DM). In many cases, diabetic patients have higher levels even after taking regular medication. This research analyzes the correlation between stress and blood glucose levels in DM in Mulyorejo public health center Surabaya. The type of this research used a cross-sectional analysis, with the population taken from DM patients. There are 40 persons with samples of 36 respondents, a sampling technique that used simple random sampling. This instrument used a questionnaire and observation sheet, data analysis using Rank Spearmen Test with significant level α =0,05. The result of the Rank Spearmen Test gained p < α that is 0,000 < 0,05 mean there is a correlation between stress level with blood glucose level in diabetes mellitus in Mulyorejo public health center Surabaya. This research concludes that stress also influences the blood glucose level of DM. In this case, the study suggests that the DM patient can control a healthy lifestyle and avoid stress, anticipating DM symptoms and increasing blood glucose levels early. Health personnel hopes to improve motivation and inform DM patients well.
Pengaruh Pemberian Masker Seledri (Apium Graveolens L.) Terhadap Pengurangan Jumlah Lesi Jerawat
Authors: Maya Septriana  , Rini Hamsidi  , Adianti Myrna , Sjioen Erikha Magdalena , Mustika Arifa , Puruhito Edith Frederika , Sumardiko Dwi Setiani , Imandiri Ario
Published: March 2024

Acne is a skin disease that is common in teenagers. In Indonesia, acne occurs around 85-100% of cases. According to the records of the Indonesian cosmetic dermatology study group, it was shown that 60% of acne sufferers in 2006, 80% in 2007 and 90% in 2009. A face with acne is an image that is not ideal for a teenager and creates dissatisfaction, causing a feeling of lack of self-confidence. One way that can be used to overcome the problem of acne is by giving a celery mask (Apium graveolens L.). Masks are cosmetic preparations for facial skin care which have the benefit of curing acne and acne scars. Celery (Apium graveolens L.) has been shown in several studies to have anti-inflammatory and antibacterial activity to prevent acne. This study aims to prove the effect of using a celery mask to reduce the number of acne lesions. The method chosen in this study was the Pretest-Posttest Control Group Design, by comparing the difference in reducing the number of acne lesions from the celery mask treatment with the paired T-test formula. The results obtained from giving celery masks to 10 young women aged 16-18 years with the classification of mild, moderate and severe acne for 2 weeks showed a significant decrease in the number of acne lesions (p = 0.00). So it can be concluded that giving celery masks can reduce the number of acne lesions in young women aged 16-18 years.
Potensi Antioksidan Fraksi n-Heksana Daun Jarak Pagar (Jatropha curcas) Terhadap Penangkap Radikal Bebas
Authors: Sudarman Rahman  , Gintoro Atilla Dian Dewanti , Arfan Arfan
Published: March 2024

Antioksidan dapat didefinisikan sebagai kelompok senyawa kimia yang dapat melindungi sel-sel dalam tubuh dari kerusakan yang diakibatkan oleh radikal bebas. Penelitian ini bertujuan mengetahui efek antioksidan fraksi n-heksana daun jarak pagar. Rancangan yang digunakan dalam penelitian adalah quasi eksperimental dengan menggunakan seri konsentrasi (10; 20; 40; 80; 100; 160 μg/mL) fraksi n-heksana dan kontrol positif (vitamin C) sebagai penghambat DPPH sebagai radikal bebas dan tiap-tiap konsentrasi dilakukan dengan tiga kali pengulangan. Penelitian dikerjakan di Laboratorium Kimia FMIPA Universitas Palangka Raya dan Laboratorium Fakultas Ilmu Kesehatan universitas Muhamadiyah Palangka Raya. Ekstrak etanol (200 gram) yang dihasilkan selanjutnya dipartisi dengan n-heksana:air (3:1) menggunakan corong pisah sehingga dihasilkan fraksi n-heksana sebesar 25,5 gram. Kemudian pengujian aktivitas antioksidan menggunakan metode DPPH (2,2-diphenyl-1-picrylhidrazil). Data yang dihasilkan kemudian dilakukan uji statistik anova satu arah, kemudian analisis lanjutan menggunakan post hoc Tamhane pada CI 95%. Hasil penelitian menunjukkan aktivitas antioksidan fraksi n-heksana daun jarak pagar (Jatropha curcas) dan kontrol positif (vitamin C) dengan nilai inhibitory concentration (IC50) berturut-turut sebesar 77,78±0,12(μg/mL) dan 8,78±0,21 (μg/mL). Berdasarkan uji anova satu arah, terdapat perbedaan yang bermakna pada masing-masing konsentrasi terhadap persen penangkapan radikal bebas (pvalue<0,05). Konsentrasi 160 μg/mL adalah konsentrasi terefektif dalam penangkapan radikal bebas. Inhibitory concentration (IC50) fraksi n-heksana daun J. curcas termasuk aktivitas antioksidan dengan kategori kuat.
Uji Stabilitas dan Aktivitas Antibakteri Sediaan Emulgel Ekstrak Etanol Buah Pare (Momordica charantia L.) terhadap Bakteri Propionibacterium acnes
Authors: Akib Nur Illiyyin , Sabarudin  , Sitti Raodah Nurul Jannah  , Mahmudah Rifa'atul , Nur Muminat Alimin
Published: March 2024

Buah pare berkhasiat sebagai antibakteri dan mengandung senyawa golongan alkaloid, flavonoid, dan saponin. Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri terhadap Propionibacterium acnes dan stabilitas sediaan emulgel ekstrak buah pare (Momordica charantia). Ekstrak buah pare 0,5%, 1%, dan 2,5% dibuat sediaan emulgel menggunakan carbopol 940 1,5%, trietanolamin 0,5%, parafin cair 5%, span 80 0,42%, tween 80 1,08%, propilen glikol 10%, DMDM Hydantoin 0,5% dan akuades. Metode cycling test digunakan sebagai uji stabilitas terhadap sediaan emulgel meliputi pengamatan terhadap organoleptik, tipe emulsi, uji homogenitas, uji pH, uji daya sebar, dan uji viskositas. Metode difusi sumuran digunakan sebagai metode untuk uji antibakteri ekstrak dan sediaan emulgel. Hasil dari penelitian ini menunjukkan sediaan emulgel ekstrak Pare memenuhi syarat emulgel meliputi organoleptik, sediaan homogen, tipe emulsi M/A, pH 5,18–5,59, daya sebar 4,9-5,4 cm, serta viskositas rentang 296,7-316,7 dPas. Sediaan emulgel ekstrak buah pare dengan konsentrasi 0,5%, 1,0% dan 1,5% dilaporkan memiliki efektifitas terhadap bakteri Propionibacterium acnes dengan klasifikasi respon hambat pertumbuhan sangat kuat.
Penentuan Toksisitas Akut Ekstrak dan Fraksi Daun Maja (Aegle Marmelos L.) dan Identifikasi Gugus Fungsi
Authors: Anwar Irvan , Yamin  , Parawansah  , Sabarudin  , Malina Rachma , Aspadiah Vica , Idrus Loly Subhiaty , Mutmainnah Nadiya
Published: March 2024

Daun maja (Aegle marmelos L.) adalah tanaman yang sering dimanfaatkan oleh masyarakat sebagai obat tradisional dan dikenal memiliki banyak metabolit sekunder. Dilakukan pengujian toksisitas untuk menilai keamanan tanaman yang digunakan sebagai bahan obat. Pengujian ini bertujuan untuk mengidentifikasi dampak beracun yang muncul dalam kurun waktu 24 jam setelah pemberian bahan/zat uji. Penelitian ini bertujuan untuk mengetahui toksisitas akut, kadar total fenolik dan flavonoid, serta identifikasi gugus fungsi pada fraksi n-heksan daun maja (Aegle marmelos L.). Pengujian toksisitas akut dengan metode Brine Shrimp Lethality Test (BSLT), penentuan kadar total fenolik dan flavonoid menggunakan spektrofotometer UV-Vis dan identifikasi gugus menggunakan spektrofotometri Fourier-Transform Infra Red. Nilai LC50 ekstrak methanol dan fraksi n-heksana dalam penelitian ini berturut-turut adalah 771,19 dan 772,77 ppm, yang artinya ekstrak dan fraksi daun maja bersifat toksik dilihat dari nilai LC50< 1000 ppm. Pada pengukuran kadar fenolik dan flavonoid total fraksi n-heksan memiliki kadar paling tinggi berturut-turut yaitu 312,10 dan 296,90 mgEQ/g. Hasil pengujian identifikasi gugus fungsi pada daun maja berdasarkan spektra FTIR menunjukkan keberagaman jenis gugus fungsi. Kesimpulan dari penelitian ini yaitu daun maja (Aegle marmelos L.) mengandung komponen kimia yang berkontribusi terhadap toksisitasnya, dan dikategorikan medium toksik (≤1,000 mg/L).
PENINGKATAN PEMAHAMAN TENTANG BAHAYA PENYALAHGUNAAN NARKOBA DAN OBAT KERAS PADA REMAJA DI SMA NEGERI 1 SOROPIA
Authors: Arba Muhammad , Muliadi Rahmat , Arfan Arfan , Mahmudah Rifa'atul
Published: March 2024

Penyalahgunaan narkoba dan obat keras telah menjadi permasalahan serius yang merugikan individu, keluarga, dan masyarakat. Untuk mengatasi masalah ini, dilakukan sebuah pengabdian masyarakat di desa pesisir, khususnya di SMAN 1 Soropia, dengan fokus pada sosialisasi mengenai bahaya penyalahgunaan narkotika dan obat keras. Pengabdian ini bertujuan untuk meningkatkan kesadaran masyarakat, terutama siswa-siswi SMAN 1 Soropia, tentang risiko dan konsekuensi negatif dari penyalahgunaan narkoba dan obat keras. Selain itu, pengabdian ini juga bertujuan untuk mempromosikan gaya hidup sehat sebagai upaya preventif dalam mengatasi penyalahgunaan. Pengabdian dilakukan dengan metode penyuluhan, pembagian leaflet, dan kegiatan interaktif melalui pemberian materi dan diskusi. Penyuluhan memberikan informasi yang komprehensif tentang jenis narkoba, dampaknya pada kesehatan fisik dan mental, serta implikasi hukumnya. Hasil dari pengabdian ini menunjukkan peningkatan kesadaran masyarakat di desa pesisir, khususnya siswa-siswi SMAN 1 Soropia, tentang risiko penyalahgunaan narkoba dan obat keras. Masyarakat menjadi lebih responsif dan proaktif dalam upaya pencegahan, dengan mengambil langkah-langkah preventif untuk menghindari penyalahgunaan obat keras. Pengabdian masyarakat ini berhasil meningkatkan kesadaran masyarakat tentang bahaya penyalahgunaan narkoba dan obat keras. Kolaborasi antara pihak sekolah, masyarakat, dan instansi terkait menjadi kunci dalam menciptakan lingkungan yang lebih aman dan sehat di desa pesisir. Melalui upaya pencegahan ini, diharapkan perubahan perilaku yang lebih positif dapat terus berkembang, sehingga kualitas hidup masyarakat di daerah pesisir dapat meningkat.
PENINGKATAN KUALITAS KESEHATAN SISWA SDN 100 KENDARI MELALUI EDUKASI PERILAKU HIDUP BERSIH DAN SEHAT
Authors: Henny Kasmawati  , Asida Nurramadhani , La Ode Muhammad Fitrawan  , Ruslin  , Aswani
Published: March 2024

Rendahnya kualitas Kesehatan di Indonesia menjadikannya sebagai salah satu fokus utama pembangunan. Usia siswa sekolah dasar merupakan usia yang tepat untuk diberikan pengetahuan mengenai pentingnya penerapan perilaku hidup bersih dan sehat. Tujuan dilakukannya pengabdian kepada masyarakat ini yaitu untuk meningkatkan pengetahuan siswa SDN 100 Kendari terhadap perilaku hidup bersih dan sehat (PHBS). Metode penyampaian materi secara ceramah dengan media materi leaflet yang berisi pengenlan PHBS dan delapan indikator PHBS di sekolah, menonton bersama video gerakan cuci tangan yang benar. Pre-test dan post-test berupa kuis dilakukan sebelum dan setelah materi. Hasil edukasi PHBS terlihat siswa sangat antusias mengikuti jalannya sosialisasi pengenalan PHBS dan mampu memperagakan gerakan cuci tangan yang benar, serta siswa sangat bersemangat menjawab post-test yang diberikan. Kesimpulan melalui edukasi siswa dapat meningkatkan pengetahuan mengenai pentingnya penerapan delapan indikator Perilaku Hidup Bersih dan Sehat di sekolah dan cara cuci tangan yang benar
SOSIALIASI TENTANG PERILAKU HIDUP BERSIH DAN SEHAT (PHBS) DAN MENGENAL KARAKTERISTIK JAJANAN SEHAT PADA ANAK SEKOLAH DASAR NEGERI 6 KENDARI
Authors: Nuralifah Nuralifah , Idrus Loly Subhiaty , Parawansah
Published: March 2024

Makanan jajanan merupakan sesuatu yang perlu menjadi perhatian karena beberapa makanan jajanan tidak higienis sehingga sangat beresiko terhadap cemaran yang dapat mengganggu kesehatan. Anak sekolah dasar sangat rentan dalam masalah ini karena anak tersebut belum mengerti cara memilih jajanan yang sehat sehingga dapat berakibat buruk pada kesehatannya sendiri. Tujuan dari sosialisasi ini adalah untuk meningkatkan pengetahuan siswa mengenai perilaku hidup sehat dan bersih (PHBS) serta mengenal jajanan sehat, bergizi dan aman. Kegiatan ini bermitra dengan SD Negeri 6 Kendari sebagai penyedia sarana sosialisasi dan Balai Pemeriksaan Obat dan Makanan Kendari sebagai narasumber. Metode yang digunakan adalah Metode yang digunakan pada kegiatan pengabdian yaitu sosialisasi persuasif secara luring mengenai dua topik utama dan dipresentasikan oleh 2 narasumber yang berasal dari Balai Pemeriksaan Obat dan Makanan Kendari dan Fakultas Farmasi Universitas Halu Oleo. Target peserta sosialisasi adalah siswa/siswi kelas 1 SD Negeri 6 Kendari. Pemberian informasi melalui slide presentasi yang dibuat menarik dan warna warni untuk menarik perhatian siswa. Selain pemberian materi, siswa SD Negeri 1 Kendari juga disajikan musik dan nyanyian 7 langkah mencuci tangan agar siswa lebih tertarik, santai, tidak mudah bosan dan lebih mudah mengikuti instruksi mencuci tangan yang baik. Hasil kegiatan menunjukkan antusiasme peserta didik sangat tinggi terlihat dari peserta didik saling berlomba-lomba untuk menjawab pertanyaan. Kesimpulan dari kegiatan ini adalah meningkatnya pengetahuan siswa SD Negeri 6 Kendari mengenai perilaku hidup sehat dan bersih serta mengenal jajanan sehat, bergizi dan aman.
SOSIALISASI DAN EDUKASI TENTANG PENTINGNYA POLA HIDUP SEHAT UNTUK MENCEGAH RESIKO HIPERTENSI DAN DIABETES MELLITUS PADA LANSIA DI PUSKESMAS JATIRAYA KENDARI
Authors: Sahumena Muhammad Handoyo , Sitti Raodah Nurul Jannah  , Loly Subhiaty Idrus  , Dian Munasari Solo  , Nurull Hikmah
Published: March 2024

Penyakit ddiabetes mellitus dan hipertensi tidak dapat diobati hanya bisa untuk dikontrol pengobatannya untuk meningkatkan kualitas hidup penderitanya. Tujuan  dari kegiatan ini yaitu memberi pengetahuan dan pemahaman lebih jelas lagi tentang penyakit diabetes mellitus dan hipertensi, memberi peningkatan pengetahuan tentang pentingnya menjaga pola hidup sehat untuk mengurangi resiko dari penyakit diabetes mellitus dan hipertensi pada masyarakat lansia di Kel. Anaiwoi. Kegiatan yang dilakukan dalam program pengabdian masyarakat ini berupa sosialisasi “Ayo t Terapkan Pola Hidup Sehat Untuk Kurangi Resiko Penyakit Hipertensi Dan Diabetes Melitus Pada Lansia” kepada masyarakat Kel. Anaiwoi, Kec. Kadia Kota Kendari, Provinsi Sulawesi Tenggara yang diikuti 27 lansia. Metode yang digunakan yaitu ceramah serta pembagian leaflet. Hasil kegiatan ini menambah pengetahuan masyarakat lansia untuk menjaga pola hidup sehat dan meningkatkan pengetahuan mengenai pengobatan hipertensi dan diabetes mellitus. Simpulan kegiatan ini yaitu bertambahnya pengetahuan masyarakat untuk menjaga pola hidup sehat dan peningkatkan kepatuhan minum obat
SOSIALISASI DAN EDUKASI BAHAYA ANEMIA DAN PENGGUNAAN TABLET PENAMBAH DARAH (Fe) PADA SISWA DI SMA NEGERI 2 KENDARI
Authors: Sabarudin  , Rifa'atul Mahmudah  , Loly Subhiaty Idrus  , Sitti Raodah Nurul Jannah  , Nurull Hikmah  , Rachma Malina  , Fifi Nirmala
Published: March 2024

SMA Negeri (SMAN) 2 Kendari merupakan salah satu Sekolah Menengah Atas Negeri yang ada di Kota Kendari  Provinsi Sulawesi Tenggara, Indonesia yang terletak di Jln. Sisingamangaraja no 41, Poasia, Kota Kendari, dan telah mengantongi akreditasi A. Total keseluruhan peserta didik pada sekolah ini sebesar 1.389 siswa, 81 guru, 4 tendik dan 4 PTK. Jumlah siswa yang cukup banyak di sekolah tersebut dianggap layak mewakili remaja di kota Kendari untuk dilakukan penyuluhan mengenai bahaya anemia dan penggunaan tablet tambah darah. Terutama, karena remaja dianggap masih minim pengetahuan mengenai anemia. Anemia terjadi karena defisiensi zat besi. Kejadian paling sering dialami oleh siswi remaja dalam periode menstruasi. Pada siswa sekolah anemia dapat meyebabkan penurunan konsentrasi dan menurunnya daya tangkap terhadap Pelajaran. Gejala anemia seperti Lelah,lelah, lesu muka pucat dan penurunan konsentrasi adalah beberapa bahaya yang ditimbulkan akibat defisiensi zat besi.  Selain itu, efek jangka Panjang seperti gagal jantung kongestif, penyakit infeksi kuman, thalasemia, gangguan sistem imun, dan meningitis jika tidak diobati dalam waktu yang lama. Tujuan dari program kemitraan masyarakat ini adalah untuk mengedukasi bahaya anemia dan penggunaan tablet tambah darah pada siswa SMAN 2 kendari dengan metode caramah dan pembagian leaflet. Siswa yang telah menerima materi terkat anemia dan tablet tambah darah meningalami peningakatan pengetahuan sebesar setelah diedukasi sehingga dapat meningkatkan kesehatan tubuh dan menghasilkan generasi muda yang lebih sehat.
PEMBERDAYAAN MASYARAKAT KELURAHAN ANGGOEYA: “KONSEP PROMOTIF DAN PREVENTIF PENYAKIT TIDAK MENULAR DALAM UPAYA MENDUKUNG SDGS”
Authors: Fristiohady Adryan , Yamin  , Nita Trinovitasari  , Wahyuni  , Nurull Hikmah
Published: March 2024

Penyakit tidak menular adalah penyakit yang tidak bisa ditularkan dari orang ke orang, yang perkembangannya berjalan perlahan dalam jangka waktu yang panjang. Tingkat kejadian penyakit tidak menular yang ada pada kelurahan Anggoeya masih cukup tinggi. Tujuan kegiatan ini adalah meningkatkan pengetahuan masyarakat terkait penyakit tidak menular untuk mencegah penyakit tidak menular dalam upaya mendukung SDGs. Metode edukasi dan sosialisasi yang dilakukan adalah ceramah dan tanya jawab dengan bantuan media leaflet. Hasil dari kegiatan ini adalah masih banyak masyarakat yang belum paham terkait penyakit tidak menular diabetes melitus dan hipertensi. Hal tersebut menyebabkan banyak masyarakat yang tidak patuh terhadap pengobatannya. Kesimpulan dari kegiatan ini adalah perlunya dilakukan edukasi dan sosialisasi sebagai konsep promotif dan preventif penyakit tidak menular dalam rangka mendukung SDGs
Examination of the Medical Error Tendencies of Midwives and Nurses Working in Maternity Clinics
Authors: Karakaş Sevda , Şahan Özlem , Akarsu Rukiye Höbek , Atilla Rabia
Published: March 2024

Aim: This research was conducted descriptively to determine the medical error tendencies of midwives and nurses working in maternity clinics and the factors affecting them.Materials and Methods: The sample of the study consisted of 135 midwives and nurses who agreed to participate in the study between January 2022 and February 2023. The Medical Error Tendency Scale in Nursing (METSN) and a descriptive information form developed by the researchers in line with the literature were used for data collection. Kruskal-Wallis and Mann-Whitney U tests were applied for data analysis.Results: The average age of the midwives and nurses participating in the study was 28.88±6.0 years, and the average duration of work was 5.84±5.9 years. It was determined that 25.4% of midwives and nurses made medical errors, and 57.8% witnessed medical errors. The mean total score of METSN was 226.20±31.78 (min-max: 126-245), and the mean scores of the sub-dimensions of the scale were determined as 84.27±10.23 for the "Medication and Transfusion Practices" sub-dimension, 55.30±9.88 for the "Prevention of Infections" sub dimension, 22.82±4.36 for the "Prevention of Falls" sub-dimension, 40.93±6.12 for the "Patient Monitoring and Material Device Safety" sub-dimension, and 22.87±4.38 for the "Communication" sub dimension.Conclusion: In our study, it was found that one-fourth of midwives and nurses made medical errors, and the risk of making medical errors was higher in midwives and nurses who had previously made medical errors and witnessed medical errors. The high rates of medical error tendencies and witnessing medical errors detected in our study indicate that there is a high tendency for medical errors in maternity clinics.
Humane slaughter in Mediterranean sea bass and bream aquaculture: farm characteristics, stakeholder views, and policy implications
Authors: van Pelt Koen , Carpendale Max , Ryba Ren
Published: March 2024

In many countries, increasing concern for animal welfare is driving retailer commitments and government legislation that aim to improve the lives of farmed fish. One aspect of fish welfare involves stunning fish prior to slaughter. The feasibility of stunning depends on the species of fish and physical farm characteristics. In this article, we provide an overview of stunning before slaughter in European sea bass and sea bream aquaculture, one of the largest finfish farming industries in the developed world that does not yet stun most of its production. Sea bass and sea bream stunning necessitates the use of electrical stunning equipment aboard harvest vessels, often a significant distance from the shoreline; this presents an interesting engineering and policy challenge. Together, Türkiye, Greece, Spain, and Italy produced over 400,000 t of sea bass and sea bream in 2020. In Türkiye and Greece, farms are numerous and located very close to the shoreline. In Spain and Italy, farms are few and located far from the shoreline. The highest average production is found in farms from Türkiye (1,000 t) and Spain (1,300 t, and lower average production is found in Greece (300 t) and Italy (350 t). Producer progress towards the installation of electrical stunning appears comparatively well-developed for Türkiye, Spain, and Greece, though we emphasise that producers and other stakeholders require continued support to realise this opportunity. Producers in Italy appear slower to make progress on this aspect of animal welfare and may require additional support.
Identification of the mining accidents by a two-step clustering method for the mining-induced seismicity
Authors: Jian Zheng , Zhao Guoyan , Wang Peicong , Liu Xingquan , Jiang Mingwei , Liu Leilei , Ma Ju
Published: March 2024

Clustering methods aim to categorize data or samples into distinct groups based on their similarity. When applying clustering methods to earthquake events, it is crucial to establish a metric for quantifying the similarity between these events. Directly applying this clustering method to a catalog of mining-induced seismicity may lead to clustering earthquake events induced by different mining activities or accidents into the same group. To address this issue, a two-step clustering method has been proposed and applied for analyzing a catalog of mining-induced seismicity. The first step involves spatial distance-based clustering of seismic events, while the second step focuses on moment tensor analysis-based clustering of these events. The results obtained from the MT-based clustering method are visualized using Hudson Graphs, and box plots serve as an evaluation tool for assessing the quality of MT clustering. Most box plots demonstrate desirable quality in terms of MT cluster results, indicating successful outcomes. By the proposed two-step clustering method combined with actual mining activities, the potential accident locations and categories can be hypothesized while valuable recommendations provided for mining operations.
Experimental study and mechanism analysis of high-pressure water jet for mud cake cutting during shield tunneling
Authors: Ji Fuquan , Liu Pengfei , Yang Zhao , Wen Bowei , Hu Qinxin
Published: March 2024

When the opening rate of the cutter head of tunnel boring machines is insufficient for the removal of excavated soil in a timely manner, the soil tends to accumulate in front of the cutter head and inside the earth or slurry chamber, leading to mud caking. High-pressure water jetting is an effective method for removing mud cakes. This study explored the influence of high-pressure water jet parameters on the efficiency of mud cake cleaning by using highly weathered argillaceous siltstone as experimental materials. Mud cake compaction equipment and high-pressure water jetting devices were developed. In addition, the impact of jetting parameters such as jet pressure and flow rate on the mud cake cutting performance was investigated. The results indicated that with an increase in the erosion distance, the cutting width of the mud cake first increased and then gradually decreased to zero, while the cutting depth progressively diminished. Under the same jet pressure, when the flow rate increased from 49.1 L/min to 110 L/min, the cutting width of the high-pressure water jet increased. With further increase in the flow rate from 110 L/min to 202.8 L/min, the cutting width decreased and the cutting depth increased. Under the same jet flow, the increase in water pressure resulted in greater cutting width and depth.
Diabetes in spotlight: current knowledge and perspectives of photobiomodulation utilization
Authors: Perrier Quentin , Moro Cécile , Lablanche Sandrine
Published: March 2024

Introduction

Diabetes is a global health concern characterized by chronic hyperglycemia resulting from insulinopenia and/or insulin resistance. The rising prevalence of diabetes and its associated complications (ulcers, periodontitis, healing of bone defect, neuropathy, retinopathy, cardiopathy and nephropathy) necessitate innovative therapeutic approaches. Photobiomodulation (PBM), involves exposing tissues and cells to low-energy light radiation, leading to biological effects, largely via mitochondrial activation.

Methods

This review evaluates preclinical and clinical studies exploring the potential of PBM in diabetes and its complications, as well all clinical trials, both planned and completed, available on ClinicalTrials database.

Results

This review highlights the variability in PBM parameters across studies, hindering consensus on optimal protocols. Standardization of treatment parameters and rigorous clinical trials are needed to unlock PBM’s full therapeutic potential. 87 clinical trials were identified that investigated PBM in diabetes mellitus (with 5,837 patients planned to be treated with PBM). Clinical trials assessing PBM effects on diabetic neuropathy revealed pain reduction and potential quality of life improvement. Studies focusing on wound healing indicated encouraging results, with PBM enhancing angiogenesis, fibroblast proliferation, and collagen density. PBM’s impact on diabetic retinopathy remains inconclusive however, requiring further investigation. In glycemic control, PBM exhibits positive effects on metabolic parameters, including glucose tolerance and insulin resistance.

Conclusion

Clinical studies have reported PBM-induced reductions in fasting and postprandial glycemia without an increased hypoglycemic risk. This impact of PBM may be related to its effects on the beta cells and islets in the pancreas. Notwithstanding challenges, PBM emerges as a promising adjunctive therapy for managing diabetic neuropathy, wound healing, and glycemic control. Further investigation into its impact on diabetic retinopathy and muscle recovery is warranted.