bluuebunny/crossref_metadata_2025 huggingface dataset:
Survival and growth dynamics of Listeria monocytogenes and Salmonella spp. on artificially contaminated cooked ready-to-eat meat products
Authors: Milanov M. V. , Mateva G. I. , Stoyanchev T. T.
Published: March 2022

The aim of the study was to evaluate the potential of survival and growth dynamics of Listeria monocytogenes strains and Salmonella enterica subsp. enterica serovar Enteritidis and Typhimurium, inoculated artificially (individually and in mixture) on two ready-to-eat (RTE) cooked smoked meat products. For the purpose of the study 120 slices of cooked smoked sausage and 40 slices of cooked smoked loin were purchased and inoculated with the strains. Two storage temperatures were selected: 6 oC and 10 oC for 8 days. The study was performed as challenge tests in a secondary contamination scenario to investigate the presence and/or absence of pathogenic bacteria during the shelf life of the products. The inoculum levels at the start of the experiment were 4.46 log10 CFU/g and 2.88 log10 CFU/g for the L. monocytogenes strains at the surface of the cooked smoked loin and cooked smoked sausage respectively. Using the same inoculation method, but adding Salmonella enterica serovars to the mixture, the inoculum levels were 4.15 log10 CFU/g at the surface of the cooked smoked loin and 2.94 log10 CFU/g at the surface of the cooked smoked sausage. L. monocytogenes was detected at all sampling days on both storage temperatures. It showed an average increase by 0.5–1.0 log10 CFU/g on the cooked smoked sausage and by 2.0–3.3 log10 CFU/g for the cooked smoked pork loin for the duration of the study. Salmonella enterica serovars were also present at each sampling day on both storage temperatures. Typical colonies were isolated and serotyped, confirming the survival of these pathogenic bacteria. Salmonella enterica subsp. enterica serovar Typhimurium was the predominant serovar at almost every sampling day. The results from our study showed no competitive relationship in the presence of Salmonella and L. monocytogenes in contaminated meat products. The two types of microorganisms were successfully adapted and developed independently under appropriate conditions, including temperature, humidity, water activity and pH.
KARMA DAN ETOS KERJA DALAM AJARAN BUDHA
Authors: Rusli Ayu Rustriana
Published: March 2022

This article aims to describe the relation between karma and work ethic in Buddhism which centred to the understanding of karma. There are two understanding of karma, namely: First, karma means the fatalism; Second, karma means optimism. The second meaning related to the work ethic based on Budhisme.  One of the concept of karma which most related to the work ethic is Karma Vipaka. It motivates Buddhists always be optimistic, earnest, diligent, tenacious, work hard, be honest, and be responsible for all actions. Based on this concept born the concept of work ethic that emphasizes that nothing will determine the fate of humans except humans themselves.Tulisan ini bertujuan untuk menggambarkan hubungan antara karma dan etos kerja dalam agama Budha yang berpusat pada konsep karma. Ada dua pemahaman tentang karma, yakni: pertama, karma bermakna fatalisme; kedua, karma bermakna optimisme. Makna kedua terkait dengan etos kerja dalam agama Budha. Salah satu konsep karma yang sangat terkait dengan etos kerja adalah Karma Vipaka. Karma ini memotivasi umat Budha untuk selalu optimis, sungguh-sungguh, rajin, ulet, bekerja keras, jujur, dan bertanggung jawab atas semua tindakan. Berdasarkan hal ini lahirlah konsep etos kerja yang menekan bahwa tidak ada yang akan menentukan nasib manusia kecuali manusia itu sendiri.
The Dynamics of Religious Conflict in Indonesia: Contestation and Resolution of Religious Conflicts in The New Order Age
Authors: Takdir Mohammad , Mushthafa M , AS Rozinah
Published: March 2022

Social conflicts in Indonesia are often associated with political turmoil and disappointment with the hegemony of power.  Therefore, it is important to understand comprehensively how the dynamics of religious conflict in Indonesia, especially during the New Order era.  As we know that this research is a literature study to understand the contestation of religious conflicts and how conflict resolution was implemented by the government in resolving ethnic-religious conflicts during the New Order era.  Using qualitative methods, this study finds that there are several factors of ethnic and religious conflicts in Indonesia, especially during the New Order era, namely group identity conflicts, levels of chaos and social mobilization, repressive actions by power groups, and collective conflicts between communal groups.  This study also shows that for the resolution of social conflicts, the government uses a repressive and security approach to control the community, and there is also a cultural approach from civil society as a form of resistance for the government.  Civil society also plays an active role in promoting peace agreements between conflicting groups.Konflik sosial di Indonesia seringkali dikaitkan dengan kekacauan politik dan kekecewaan terhadap hegemoni kekuasaan. Karena itu, penting untuk memahami lebih komprehensif bagaimana dinamika konflik agama di Indonesia, khususnya pada masa Orde Baru. Sebagaimana kita ketahui bahwa. Penelitian ini merupakan studi kepustakaan untuk memahami kontestasi konflik agama dan bagaimana resolusi konflik yang diterapkan oleh pemerintah dalam penyelesaian konflik agama-etnis pada masa Orde Baru. Menggunakan metode kualitatif, penelitian ini menemukan bahwa ada beberapa faktor konflik etnis dan agama di Indonesia, khususnya pada masa Orde Baru, yaitu konflik identitas kelompok, tingkat kekacauan dan mobilisasi sosial, tindakan represif oleh kelompok kekuasaan, dan konflik kolektif diantara kelompok komunal. Penelitian ini juga menunjukkan bahwa untuk penyelesaian konflik sosial, pemerintah menggunakan pendekatan represif dan keamanan untuk mengontrol masyarakat, dan juga ada pendekatan budaya dari masyarakat sipil sebagai salah satu perlawanan bagi pemerintah. Masyarakat sipil juga berperan aktif dalam mendorong kesepakatan damai antara kelompok-kelompok yang berkonflik.
The Ecological Dimension of Confucian Religion: Perceiving Human-Nature Relation in the Anthropocosmic Principle
Authors: Umbu Deta Krisharyanto
Published: March 2022

The religious discourse has been dominated by the paradigm of world religions especially the Abrahamic religions like Islam and Christianity, shaping the way religion being understood and associated with other issues. Its strong emphasis on the ultimate being called God has resulted in commonly accepted categories of what could be counted as religion or more religious. It then brings a strict distinction between the sacred and the profane or secular. The issues of ecology, economics, politics, etc., therefore, are often dissociated from religions. This paper aims to challenge that paradigm by promoting Confucian distinctive ways of being religious which have been commonly perceived as having much to do with humanity or social matters. This paper, by using literature study as the method of research, further show the important significance of Confucian religiosity on the issue of ecology. In so doing, the discussion is framed in the underlying assumption of the contemporary ecological discourse on the idea of interconnectedness that humanity and ecology, as well as social and natural science, are actually intertwined and inseparable. Putting that under the term ‘religiosity’, it broadens our understanding of religiosity and implies great significance religions can contribute to the contemporary issues. It is also assumed here that social welfare of human beings cannot be separated from natural welfare of non-human beings since both are interdependent.Wacana keagamaan yang didominasi oleh paradigma agama dunia khususnya agama-agama Abrahamik seperti Islam dan Kristen, membentuk cara padang terhadap agama yang dipahami dan dikaitkan dengan isu-isu lain. Penekanannya yang kuat pada wujud tertinggi yang disebut Tuhan telah menghasilkan kategori-kategori yang diterima secara umum dari apa yang dapat dianggap sebagai agama atau lebih religius. Ini kemudian membawa perbedaan tegas antara yang sakral dan yang profan atau sekuler. Oleh karena itu, isu-isu ekologi, ekonomi, politik, dan lail-lain., seringkali dipisahkan dari agama. Artikel ini bertujuan untuk menantang paradigma tersebut dengan mempromosikan cara-cara beragama yang khas Konfusianisme yang selama ini dianggap banyak berhubungan dengan kemanusiaan atau masalah sosial. Dengan menggunakan studi kepustakaan sebagai metode penelitian, selanjutnya artikel ini menunjukkan pentingnya religiositas Konfusianisme dalam masalah ekologi. Dengan demikian, diskusi dibingkai dalam asumsi yang mendasari wacana ekologi kontemporer tentang gagasan keterkaitan bahwa kemanusiaan dan ekologi, serta ilmu sosial dan alam, sebenarnya saling terkait dan tidak dapat dipisahkan. Menempatkan bahwa di bawah istilah 'religiusitas', itu memperluas pemahaman tentang religiositas dan menyiratkan signifikansi besar agama dapat berkontribusi pada isu-isu kontemporer. Di sini juga diasumsikan bahwa kesejahteraan sosial manusia tidak dapat dipisahkan dari kesejahteraan alam non-manusia karena keduanya saling bergantung.
KINERJA KEUANGAN PERUSAHAAN DI BURSA EFEK INDONESIA SELAMA MASA PANDEMI COVID-19
Authors: Kustinah Siti
Published: March 2022

Various types of businesses in Indonesia experienced a decline in their financial performance as a result of the Covid-19 pandemic which had a negative effect on the economy. The purpose of carrying out this research is to be able to see how the effects of the Covid-19 pandemic on the financial performance of several companies listed on the Indonesia Stock Exchange. The research sample used was 214 companies with data analysis using the Wilcoxon Signed-Rank test. The research then succeeded in finding that there was an increase in the leverage ratio and the short-term activity ratio. However, during the pandemic, it was found that there was a decline in the liquidity ratio and profitability ratio. This increase and decrease changed before the pandemic to the current pandemic.KINERJA KEUANGAN PERUSAHAAN DI BURSA EFEK INDONESIA SELAMA MASA PANDEMI COVID-19
A Daylight Assessment on Visual and Nonvisual Effects of Light Shelves: A Human-centered Simulation-based Approach
Authors:   Department of Interior Architecture, Faculty of Architecture & Urbanism, Tehran University of Art, Tehran, Iran, Hosseini Seyedeh Nazli , SheikhAnsari Iman ,   Faculty of Architecture and Urbanism, Art University of Isfahan, Isfahan, Iran
Published: March 2022

The contribution of daylight to a comfortable environment for occupants has been the subject of studies for years. Light shelves are known as daylight redirecting systems to enhance indoor daylight conditions. Although several research papers have focused on their daylight performance, there is a lack of studies on the performance of light shelves on circadian rhythm. In this context, daylight's biological effects on human beings have been under investigation. Therefore, this paper aims to evaluate the performance of light shelves in terms of visual and nonvisual effects of daylight, including circadian stimulus, visual comfort, and task performance through a multi-criteria human-centric evaluation. To this end, the authors set three following conditions if a model could provide simultaneously, the occupants would be in a comfortable space both visually and non-visually: 75% workstations with Equivalent Melanopic Lux> 250 EML concurrently with Vertical Photopic illuminance < 1500 lux, and Photopic illuminance on working plane > 300 lux. Accordingly, the light shelves with various depths, states, and orientations were simulated by ALFA to evaluate the comfort of occupants in office space over working hours. The results indicated that although applying light shelves impacted the metrics, the enhancements were minor compared to a conventional window, specifically on EML. In detail, inadequate EML levels were observed in all orientations on the simulation days. Besides, changes in the photopic illuminance at the eye and workstations levels were not substantial. Finally, the paper presents a case study that showcases simulation techniques that focus on daylighting and circadian rhythm.
CRISPR/Cas-based diagnostic platforms
Authors: Volkov A. A. , Dolgova A. S. , Dedkov V. G.
Published: March 2022

Over the last few years, CRISPR/Cas systems have been extensively studied and used for a wide range of applied purposes. The variety of their applications is accounted for by the ability of Cas-type nucleases to targetly cleave specified nucleic acid sequences. In this case, the researcher might set the necessary sequence of the guiding elements in the CRISPR/Cas system, played by so-called single guide RNAs allowing it to act on select targets. This potential underlies one of the reasons for exerting interest in CRISPR/Cas systems. One of the first areas for applying these systems was its use for genomic editing. Later, the list of potential opportunities has been expanded: e.g., they can be used in gene therapy and epigenetic research. It is possible to create sgRNA libraries which might be used to create a pool of viral vectors applied for bacterial cell transformation with subsequent cas-protein transduction that cause target gene knockout. This approach allows finding genes responsible for resistance or sensibility to diverse substances. Using such systems in molecular diagnostics of infectious diseases is considered as one of the most promising directions allowing to detect even extremely low concentrations of pathogenic organisms in samples due to their specific nucleotide sequences. Simultaneously, such assays turn out to be accurate, rapid and easy to utilize. In addition, some platforms may work without using expensive equipment, because methods for fast and simple sample preparation have already been developed, whereas modern preamplification approaches allow to avoid applying thermocycling devices. Interestingly, a great amount of diverse types of natural CRISPR/Cas systems have been already discovered. Such abundance promotes development of multiple artificial systems, each of which exerting own unique characteristics. Therefore, a variety of diagnostic platforms with different properties are created on their basis that allows researchers and physicians to choose an optimal approach for performing specific tasks. For this reason, insights into structure and operation of CRISPR/Cas systems are necessary for selecting a suitable platform. The current classification of systems is based on such principles serving as the basis, in turn, for convenient evaluation of the very variety of molecular diagnostics platforms and presentation of the typical technical characteristics and nuances for each method. Thus, this review, which is mainly devoted to the platforms for molecular diagnostics of infectious diseases, also touches upon the issues of functioning, devices, and classification of CRISPR/Cas systems.
Fungal allergies in patients with atopic dermatitis and psoriasis
Authors: Barilo A. A. , Smirnova S. V.
Published: March 2022

Examining a role of fungal allergy in the development of atopic dermatitis (AD) and psoriasis (PS) is of particular interest and determines the relevance of the current study. The purpose of the study is to analyze and carry out a comparative analysis for multiple sensitizations to fungal allergens in patients with AD and PS. Materials and methods. The study involved patients with atopic dermatitis (group 1, n = 53, mean age 33.0±1.3 years) and psoriasis (group 2, n = 53, mean age 40.0±1.8 years) aged from 18 to 66 years old. Sensitization to fungal allergens was assessed by skin prick testing with standardized fungal allergens: Candida albicans, Alternaria alternata, Aspergillus fumigatus, Cladosporium herbarum, Penicillium notatum (Allergopharma, Germany) and nutritional yeast (Microgen, Russia). The concentration of allergen-specific IgE to a mixture of fungal allergens: Penicillium notatum, Cladosporium herbarum, Aspergillus fumigatus, Mucor racemosus, Alternaria alternata (Alkor Bio, Russia) was determined by the method of indirect immunofluorescence analysis on a semiautomatic analyzer Multiskan FC (ThermoFisher Scientific, Finland). The test was considered positive at an IgE level of ≥ 0.35 kE/L. Statistica 8.0 software package was used for statistical analysis. Results and discussion. When studying the features of sensitization to fungal allergens, it was determined that in the group of patients with AD was the highest frequency of sensitization to nutritional yeast, as well as fungi of the genus Alternaria alternata and Cladosporium herbarum. In the group of PS patients, the highest frequency of sensitization to fungi of the genus Cladosporium herbarum, Aspergillus fumigatus and Alternaria alternata was found. When studying intergroup differences, it was determined that the rate of sensitization to fungi was insignificantly higher in the group of patients with PS in comparison with AD. Sensitization to a mixture of fungal allergens based on the concentration of allergen-specific IgE was more often observed in the group of AD patients vs. patients with PS: 15% versus 5,3%. Most likely, reagins of a different class (IgG4) can participate in the development of AD and PS, or other immunopathological mechanisms of allergy triggering (according to the Gell and Coombs classification) can be involved. Thus, fungal allergy may play an important role in the etiopathogenesis of atopic dermatitis and psoriasis. Our research can guide clinicians in terms of personalized approaches to the diagnosis and treatment of these pathologies, including specific allergological examination, not only for patients with AD, but also for those with PS.
Modernist Aesthetics and Consumer Culture in Oscar Wilde Journalism
Authors:   Kazan Federal University, Bakanov Roman P. , Egorova Lilia G. ,   Kazan Federal University, Tumanov Dmitrii V. ,   Kazan Federal University
Published: March 2022

The article reveals the specifics of the author’s view and creative position in the journalistic works of the famous Irish writer Oscar Wilde. The authors of the article found that he everywhere sought to capture the real world in its mobility and variability through his fleeting impressions. The impressionism of his works focused on the fluidity of the moment, the changeability of mood or a paradoxical angle of view. Wilde, the publicist, did not want to document the described reality. He recorded instantaneous changes in his perception, reproducing through images the impressions that were born in him at one time or another. Wilde’s world is a world of subjective, original impressions, it is decorative, excessively picturesque, but it is a world of deliberate and even invented impressions, and not spontaneously, impulsively born in the perception of the artist. The authors of the article believe that many of the writer’s thoughts and conclusions are relevant to the Russian society of the present time.
The Inexpressible, the Incomprehensible and the Indescribable in Words: the Paradox of the Existence of Poetic Speech
Authors:   Donetsk National University, Gataullina Dinara N.
Published: March 2022

The article examines the main contradiction of poetry: the inability to fully convey impressions of the world in a sounding speech and the desire to continue attempts at utterance. The relevance of the topic lies in the importance for each person of asserting their own “I” through speaking and finding ways to realize this goal. In the course of the study, it was found that poetic speech represents the incomprehensible and inexpressible by a combination of verbal description and accompanying omissions.
Efficacy of Endoscopic Band Ligation in the Treatment of Acute Esophageal Varicose Bleeding
Authors: ÇALIK Mustafa , IRAK Kader
Published: March 2022

Objective: To determine the efficacy of endoscopic band ligation (EBL) on rebleeding and mortality in the treatment of esophageal varices bleeding.

Methods: Fifty cirrhosis patients who applied to the emergency department with acute esophageal variceal bleeding between 2018 and 2020 and were treated with EBL within the first 12 hours were evaluated retrospectively.

Results: Twenty-seven (54%) patients were male and 23 (46%) were female. The mean hospital stay of the patients was 6.45.6 days, and the mean blood transfusion requirement was 3.62.7 units. Re-bleeding was observed within 30 days in 5 (10%) patients and within 1 year in 7 (14%) patients. Ten (20%) patients died within 30 days, and 11 (22%) patients died within 1 year. The need for blood transfusion was higher in patients with grade 3 varicose veins (4.93.1) than in patients with grade 2 varicose veins (2.51.5) (p=0.001). Mortality rate within 30 days and 1 year was significantly higher in patients with grade 3 varicose veins (p=0.001). Although the rate of bleeding within 30 days and 1 year was higher in patients with grade 3 varicose veins than in patients with grade 2 varices, the difference was not significant (p=0.087).

Conclusion: EBL is an endoscopic treatment method to be preferred in patients with acute esophageal variceal hemorrhage due to its low risk of re-bleeding and low mortality rate.
The Effect of Body Weight on Sleep Quality and Sleep Duration in Adolescents
Authors: YILMAZ Beytül , ÇİÇEK Betül , KANER Gülşah
Published: March 2022

Aim: The aim of the present study was to determine the effect of body weight on sleep duration and sleep quality in adolescents.

Material and Method: This cross-sectional study was performed on 14-17 year old adolescents (n=1072) attending to public and private high schools. In order to determine the sleep quality, Pittsburgh Sleep Quality Index (PSQI) was filled, and sociodemographic data were collected through a questionnaire. Body weight, height, waist and hip circumferences were measured and body mass index (BMI), waist to hip ratio were calculated.

Results: In the least sleeping group (
Evaluation of Patients Diagnosed with Ileus in the Emergency Department
Authors: DERDİYOK Çağdaş , SALT Ömer , SAYHAN Mustafa Burak
Published: March 2022

In emergency department, a delayed diagnosis and treatment of ileus causes a substantial increase in morbidity and mortality. : In this study we aimed to determine the major risk factors of mortality and hospital stay length in patients with ileus. It was determined that blood transfusion requirement; lactate, total bilirubin, and C-reactive protein levels; presence of colon cancer; and mean arterial pressure were among the parameters that can be used for predicting mortality in patients with ileus. In addition, qSOFA value and potassium, sodium, and total protein levels were determined to be among the parameters that are effective for determining the need for surgery in patients with ileus.
Construção de mercados agroalimentares
Authors: Camara Simone , Lago Adriano , dos Santos Amorim Gabrieli , Pietrobelli Valeska , Andreatta Tanice , Marisa Spanevello Rosani
Published: March 2022

Introdução: O objetivo deste artigo é investigar o papel da Cooperativa Familiar do Extremo Norte Mista de Produção Agroindustrial na Produção e Fornecimento de Alimentos para agricultura familiar, não no município de Alpestre e região.

Metodologia: Trata-se de um estudo exploratório e de abordagem qualitativa, baseado em um estudo de caso. As informações foram coletadas no meio de uma entrevista realizada no máximo em setembro de 2018, conduzida por um roteiro semiestruturado que continua sendo coberto desde a fundação da cooperativa até os canais de comercialização acessados ​​por ela.

Resultados: A Ressalta-se, papel fundamental do Programa Nacional de Alimentação Escolar (PNAE), representa um canal institucional de mercado e marketing cooperativo, com a visão de que a responsabilidade da parte principal da produção e a possibilidade de aumentar a produção do programa intermediário de couro cabeludo direcionado sob demanda.

Conclusões: uma contribuição para reforçar a importância das cooperativas agrícolas para a agricultura familiar e, quando acompanhadas de políticas públicas eficazes, incentivar ou desenvolver agricultores, principalmente em relação às exigências comerciais e legais, além de estimular ou desenvolver o desenvolvimento econômico. e o social não está entrando, notam-se dificuldades em relação aos dias de entrega das instituições e limitações entre um sistema de produção restrito ao sistema cooperativo de dois agricultores.
Editorial
Authors: Frahm-Arp Maria
Published: March 2022

The Pentecostal movement has since its inception been a dynamic movement in which the theology, practice, and expressions of faith have shifted. This is primarily, but not solely, due to four central factors. First, it is a movement and not a centralized organization, meaning that there is no central authority that governs how it develops, when and how new congregations or churches are formed, and how these evolve. As a movement, it is a loose collection of churches and groups, some of which do not specifically self-identify as Pentecostal, but are categorized by academics as Pentecostal due to their theology and/or practices. The article by Podolecka and Cheyeka explores this reality in Zambia where some churches consider themselves Pentecostal while other Pentecostals do not recognize these churches as part of the movement. In a different vein, Aidoo examines the phenomena of cursing prayers in which pastors criticize each other and claim other pastors as not being Christians in their prayers. Second, there is no centralized canonical theology determined by a particular body or group with authority to establish and enforce rules or regulations, meaning that the groups and churches in the movement are free to development their own theologies. The article by Resane explores this idea as he examines the impact of the Shepherding Movement within Pentecostalism and how a group of five men in the USA established a model for how churches should be run, but the movement was problematic and fell apart in the 1990s.
Copyright Amendment Bill Workshop Proceedings Report
Authors: Gledhill Igle , Goldstone Richard , Samtani Sanya , Tomaselli Keyan , Beiter Klaus
Published: March 2022

The genesis of the Copyright Amendment Bill was in 2009, when the Department of Trade and Industry (DTI) initiated various studies and impact assessments. In July 2015, the DTI published a Draft Copyright Amendment Bill for public comment. The final 2017 version of the Bill was approved by Parliament in 2019 and it was sent to President Cyril Ramaphosa for action in terms of Section 79(1) of the Constitution. Section 79(1) states that “The President must either assent to and sign a Bill passed in terms of this Chapter or, if the President has reservations about the constitutionality of the Bill, refer it back to the National Assembly for reconsideration”. The President referred the Bill back to Parliament for review on 16 June 2020, on constitutionality issues. In response to the President’s reservations, Parliament’s Portfolio Committee on Trade and Industry has invited stakeholders and other interested parties to submit written submissions on certain sections of the Bill by no later than 9 July 2021. The current copyright law is outdated and does not address the digital environment. The Academy of Science of South Africa seeks to take into account the status of the copyright legislation and the anticipated effects of the amendment Bill on different issues and thereafter, provide recommendations to the President.
[RETRACTED] Strive Nutrition Keto Reviews (Updated 2022) Diet Pills: Is It safe? Check Here v1
Authors: Nutrition Keto Strive
Published: March 2022

[RETRACTED]

Strive Nutrition Keto Reviews (Updated 2022) Diet Pills: Is It safe? Check Here
[RETRACTED] Naturals Best Brain Cognitive Support v1
Authors: not provided bestbraincognitiv
Published: March 2022

[RETRACTED]

Best Brain Cognitive Support is a supplement and a Japanese memory pill that has recently become available in America. The memory support supplement, which is backed by over 100 studies, is now approved by leading U.S. doctors recommending it for use by seniors.
Wajah Baru Ronggeng Kedempling di Kabupaten Majalengka (Suatu Kajian Historis Tahun 2000-2018)
Authors: Quraysshyhaq Aldi , Santosa Ayi Budi
Published: March 2022

The dynamics that occurred in Ronggeng Kedempling dance art in Majalengka Regency during the period 2011-2018, there was an effort to revitalize this art that was initially vacuum and unknown to the public became one of the icons of traditional art originating from Majalengka Regency. The artists made changes to the traditional arts due to negative views and aimed to make Ronggeng Kedempling dance acceptable to the community. The method used in this study is a historical method consisting of heuristics, source criticism, and historiography and assisted by interdisciplinary science, namely sociology and anthropology. While data collection techniques are carried out through literature studies, documentation studies and interviews. Based on the findings, Ronggeng Kedempling dance art is a traditional art undergoing changes and adjustments due to social changes in the supporting community. The change in the supporting component of the arts is the result of creativity and innovation from artists. Various preservation efforts have been made so that this art can withstand the changing conditions of the times. As for the preservation efforts of the artists by doing devolution, ronggeng kedempling dance learning in workshops and in schools and activities in the making of muri records.
Literasi Digital: Urgensi dan Tantangan dalam Pembelajaran Sejarah
Authors: Hidayanti Puspatriani Nur
Published: March 2022

Penelitian ini membahas tentang urgensi literasi digital dan tantangannya dalam konteks pembelajaran sejarah, sejalan dengan penggunaan teknologi dan informasi yang telah berkembang pesat, kemampuan dalam mencari sumber informasi yang dapat dipertanggung jawabkan menjadi sebuah kewajiban yang harus dikuasai oleh seseorang sebagai pengguna sumber informasi. Dalam konteks literasi digital, setiap orang memerlukan kemampuan untuk melakukan pencarian di internet, pandu arah hypertext, evaluasi konten informasi dan penyusunan pengetahuan. metode yang digunakan dalam penelitian ini yaitu metode deskriptif kualitatif, karena penelitian yang dilakukan memiliki subjek penelitian yang merupakan bagian dari gejala sosial, situasi lapangan disajikan tanpa dimanipulasi. Adapun dampak positif dari diterapkannya literasi digital dalam pembelajaran sejarah yaitu: (1) membantu proses pembelajaran;(2) memaksimalkan kemampuannya dalam berpikir kritis dan kreatif serta memiliki pola pemikiran yang berbeda karena tidak adanya keterbatasan dalam mendapatkan sumber pengetahuan;(3) membuka peluang bagi guru untuk lebih produktif dalam menggunakan teknologi digital dalam pembelajaran.Literasi Digital : Urgensi dan Tantangan dalam Pembelajaran Sejarah
Pendidikan bagi Perempuan Indonesia : Perjuangan Raden Dewi Sartika dan Siti Rohana Kudus (1904-1928)
Authors: Jayudha Irfan Agung , Darmawan Wawan , Wiyanarti Erlina
Published: March 2022

ABSTRAKPenelitian ini mengkaji mengenai perbandingan peranan Raden Dewi Sartika dan Siti Rohana Kudus dalam memperjuangkan pendidikan perempuan di Indonesia dengan rentang waktu dari 1904-1928. Latar belakang dalam penelitian ini adalah Raden Dewi Sartika dan Siti Rohana Kudus memiliki pemikiran dan tindakan berbeda dengan perempuan pada umumnya pada masa itu. Keduanya hidup pada zaman yang sama, tetapi berada di daerah yang berbeda. Masalah utama yang diangkat dalam penelitian ini adalah bagaimana perbandingan peranan yang dilakukan oleh Raden Dewi Sartika dan Siti Rohana Kudus dalam memperjuangkan pendidikan bagi perempuan . Metode yang digunakan dalam penelitian ini adalah metode historis dengan menggunakan empat langkah penelitian yaitu heuristik, kritik, interpretasi dan historiografi dengan teknik pengumpulan data menggunakan teknik studi literatur. Berdasarkan hasil penelitian ini, dapat dijelaskan bahwa Raden Dewi Sartika dan Siti Rohana Kudus memiliki persamaan dan juga perbedaan. Persamaan keduanya yakni berkeinginan untuk mengangkat derajat kaum perempuan dengan jalan pendidikan dalam memperjuangkan pendidikan bagi perempuan dengan mendirikan sekolah untuk perempuan dan juga turut aktif dalam pergerakan nasional. Adapula hal yang menjadi landasan kuat bagi keduanya adalah dapat menjadi ibu yang baik bagi anak-anaknya kelak. Akan tetapi, Raden Dewi Sartika dan Siti Rohana Kudus tetap memiliki perbedaan peranan dalam pergerakan nasional dan perbedaan dalam  proyeksi lulusan dari sekolah yang keduanya dirikan. Kata Kunci : Pendidikan Perempuan, Raden Dewi Sartika, Siti Rohana Kudus
Changes in levels of urokinase receptor and other components of fibrinolytic system in brain tissues in urokinase gene-knockout mice with B16/F10 melanoma growing together with chronic neurogenic pain
Authors: Frantsiyants E. M. , Bandovkina V. A. , Kaplieva I. V. , Cheryarina N. D. , Surikova E. I. , Neskubina I. V. , Pogorelova Yu. A. , Nemashkalova L. A.
Published: March 2022

Purpose of the study. An analysis of the changes in components of the urokinase system in the brain of urokinase gene-knockout mice (uPA-/-) with B16/F10 melanoma growing alone and together with chronic neurogenic pain (CNP).

Materials and methods. The study included male and female C57BL/6-PlautmI.IBug-ThisPlau6FDhu/GFDhu mice (uPA-/-) (n = 48) and C57BL/6 mice (uPA+/+) (n = 80) with transplanted B16/F10 melanoma growing solitarily and together with CNP. Levels of the urokinase receptor (uPAR) and plasmin (PAP) and activity and levels of the PAI-I inhibitor were measured in the brain of animals by ELISA.

Results. Levels of uPAR, PAI-I and PAP in the brain differed only in intact uPA-/- males, being on average 1.6 times higher (p < 0.05) than in uPA+/+ mice. Among animals with CNP, uPA-/- males showed increased PAI-I by 1.3 times (p < 0.05) and decreased PAP by 2.6 times (p < 0.05), while in uPA+/+ males, changes in PAI-I and PAP were opposite; in uPA-/- females, levels of all indicators increased by 1.6–2.1 times (p < 0.05), unlike uPA+/+ females. Among animals with melanoma only, changes in the levels of uPAR, PAI-I and PAP in the brain tissues in uPA-/- males differed from the group with CNP and from uPA+/+ males; in uPA+/+ females, levels of uPAR and PAP increased by 1.7 and 3.0 times (p < 0.05), and only PAP increased in uPA-/- females by 3.2 times (p < 0.05). Combination of CNP with melanoma in uPA-/- mice, regardless of their gender, down-regulated levels of uPAR and PAI-I on the average by 1.5 and 2.0 times, respectively (p < 0.05), and up-regulated PAP on the average by 2.2 times (p < 0.05) compared to the levels in animals with CNP; in uPA+/+ animals, similar decline of uPAR by 3.7 times (p < 0.05) was registered only in males, and an increase of PAI-I by 2.0 times (p < 0.05) was noted in all mice.

Conclusion. Changes in the studied parameters in the brain tissue of urokinase gene-knockout animals in response to stress factors indicate the role of the brain urokinase system in the response to both CNP and melanoma growth, and the gender specificity of these changes may be another factor that conditions gender differences in the risk of occurrence and course of cutaneous melanoma.
Inhibition of growth of colorectal cancer patient-derived subcutaneous xenografts using combined Wnt signaling pathway inhibitor and 5‑fluorouracil
Authors: Goncharova A. S. , Galina A. V. , Khodakova D. V. , Egorov G. Yu. , Maksimov A. Yu. , Kolesnikov E. N. , Komarova E. F. , Kiblitskaya A. A. , Zaikina E. V. , Kurbanova L. Z. , Mindar M. V.
Published: March 2022

Purpose of the study. Was to analyze antitumor efficacy of the XAV 939 Wnt signaling pathway inhibitor and its combination with 5 fluorouracil in subcutaneous xenografts derived from patients with colorectal cancer.

Materials and methods. Antitumor efficacy of the agents and their combination was studied in xenografts derived from patients with colorectal cancer and subcutaneously implanted in immunodeficient Balb/c Nude mice. All animals with tumors were divided into 4 groups (n = 5): group 1 received 5 fluorouracil 25 mg/kg, group 2 – XAV 939 25 mg/kg, group 3–5 fluorouracil and XAV 939 combination at the same dosages, group 4 was control. Criteria for the efficacy of the tested agents and their combination included tumor growth rate and tumor growth inhibition rate (TGI %).

Results. The mean volumes of xenografts and tumor growth rate in the group receiving a combination of 5 fluorouracil and XAV 939 were 335.2 ± 40.7 mm3 , being lower than the averages of xenografts in controls – 609.3 ± 69.5 mm3 (p < 0.05). The mean volumes of xenografts in the group receiving 5 fluorouracil monotherapy were 601.9 ± 45.5 mm3 , in the group with the XAV 939 monotherapy – 527.9 ± 258.6 mm3 . The highest TGI (44.99 %) was registered in the group receiving a combination of 5 fluorouracil and XAV 939.

Conclusion. The study revealed the ability of combined XAV 939 Wnt signaling pathway inhibitor and 5 fluorouracil to inhibit the growth of subcutaneous xenografts derived from patients with colorectal cancer.
Lung cancers biomarkers
Authors: Kharagezov D. A. , Lazutin Yu. N. , Mirzoyan E. A. , Milakin A. G. , Stateshny O. N. , Leiman I. A. , Iozefi K. D.
Published: March 2022

More than 1.8 million of new cases of lung cancer (LC) are registered each year worldwide. LC is the leading cause of cancer death in both developing and developed countries, and the 5 years survival rate is as low as 19 %. Many factors explain such unsatisfactory outcomes, including the LC diagnosis at an advanced stage, when the currently available treatments can rarely provide cure. Biomarkers are used to assess the development risks, screening, diagnosis, monitoring, and prognosis, and to personalize the LC treatment. Clinical use of biomarkers is essential for the identification of a high-risk group for screening for LC and differentiating early LC from benign pulmonary lesions. Current trends in the development of LC biomarkers involve the integration of molecular biomarkers with clinical and radiological characteristics using artificial intelligence for the development of imaging biomarkers, and using highly sensitive technologies such as next-generation sequencing for molecular research. LC biomarkers are now at all stages of development, from discovery to clinical trials requiring high-quality clinical validation. Reliable biomarkers are especially needed to differentiate malignant and benign lesions in the lung tissue and to identify those at greatest risk of developing lung cancer. Scientific advances in understanding LC have led to the development of biomarkers that demonstrate sufficient accuracy in clinical validation studies. Promising trends in the development of LC biomarkers include highly sensitive and increasingly accessible NGS and radiomics technologies, along with the use of easily collected biomaterials, which in combination with other tumor characteristics contribute to the development of biomarkers for assessing the LC development risks, diagnosis, monitoring, prognosis and personalized therapy. This review focuses on the development, current application, and future trends in the use of LC biomarkers.
SEVEN SAGES OF GREECE: BETWEEN DEMOCRACY AND TYRANNY
Authors:   Taras Shevchenko National University of Kyiv, Turenko Vitalii , Oliinyk Artem ,   Taras Shevchenko National University of Kyiv
Published: March 2022

In the study, in the context of the theme of the seven sages of Greece, the corpus of factual material was analyzed, followed by the use of general scientific and specific methods, and the author’s conclusions were obtained, including those of a misdirected nature. The thesis is substantiated that philosophy arises not only as a departure from mythological perception, but also as an activity-based reflection on socio-political reality in a particular polis. Accordingly, despite the fact that the sages perceived philosophy only as a reflection on nature, but as a study of the surrounding world and, on the basis of this, an attempt to make this or that political reality stable and loyal to all residents of a particular polis. Based on previous scientific works at the intersection of philosophy, political science, history, linguistics and semantics, the context of the use of a number of important concepts is clarified, regardless of further connotational loads, which has transformed meanings from time to time. Accordingly, the main focus of the article focuses on the dichotomous division of the seven wise men into parties: democrats and tyrants. Since the attitude towards tyrants and the phenomenon of tyranny is more or less positionally expressed in the philosophical tradition since Plato, the main issue was precisely in the temporal segment of the «pre-Platonic», pre-classical, and then it was complicated by numerous factors. Among them, in addition to the limited primary sources, there is a difference in the interpretation of ancient allegories, the imposition of a modern understanding of socio-political processes on the socio-economic conditionality of the inhabitants of the policies more than 2.5 thousand years ago, and the like. This creates a challenge for comprehending a full-fledged political picture of life or Ionia, or continental Hellas. Based on specific and comprehensive data, for example, the duties and powers of certain state officials of the archaic era, it was possible to theorize and find their confirmation / refutation in works of a later period. This constituted an important part of the study, as the aim is to provide an unbiased analysis of both parties and their supporters, regardless of the moral and ethical side. The main thing here is the clarification of the role, place, importance and popularity of both approaches to the 404 event in Athens, which qualitatively changed public discourse in a decisive way, completely moving away in black and white tones.
Towards physiology and depressoris
Authors: Fofanov Lev L.
Published: March 2022

Having clarified our view of the depressor nerve, we will now move on to solving the question of the method of its action on the vasomotor center, that is, what exactly happens when the depressor is irritated, the center of the vasoconstrictors is depressed, or the excitation of dilators, or both. But before talking about my own research, I will point out some literary data on this issue.
Laignel-Lavastine et Boudon. ideational apraxia. Arguee ideatone. Revue neurol. 1909, № 4
Authors: Osokin N. E.
Published: March 2022

A case is described in detail concerning a 54-year-old seamstress whose medical history falls into 3 periods: 1-Slow and progressive decline in mental activity with amnesia and complete inability to perform normal work, 2nd period with a more extensive mental disorder, 3rd period after a few months from the onset of the disease was expressed by a significant improvement.
Chronicle and mixture, Vol. XVI, № 2 (1909)
Authors: Baklushinskiy Ivan D.
Published: March 2022

Prof. Nikolai Mikhailovich Popov at a meeting of the 2nd p. May unanimously elected dean of the Medical Faculty of Novorossiysk University.

From the 1st to the 5th of June of the current year, the second All-Russian congress on pedagogical psychology will take place in St. Petersburg, in the premises of the Salt Town. The organizing committee includes: chairman, academician V. M. Bekhterev, comrades of the chairman A. A. Krogius, A. F. Lazursky, D. M. Levshin and A. P. Nechaev and members D. A. Dril, M. I Konorov, N. E. Rumyantsev, V. V. Uspensky, G. A. Falbork. L. G. Orshansky, Pr.-Assoc. Zhakov, N. K. Kulman, A. I. Zaginyaev, Ya. I. Dushechkin, S. Yu. Blumenau. V. V. Rakhmanov, N. I. Neklyudova, E. S. Dedyulina and others. The members of the congress can be teachers of higher and secondary educational institutions, doctors and persons who have declared themselves to be published works in the field of psychology and school hygiene. All those interested in educational psychology are allowed as guests.
Chronicle of the Society of Neurologists and Psychiatrists at the Imperial Kazan University of December 17, 1908
Authors: Darkshevich Liveriy O. , Pervushin Vsevolod P.
Published: March 2022

Dr. Pervushin. An interesting report by I. A. is supported by such convincing anatomical and physiological data concerning the treated area that one can fully agree with his conclusions regarding the nature of the painful phenomena of the described case. Only on the question of the participation in this case of the lesion of the spinal cord itself, I would take a somewhat different view, or rather be more categorical: there was no direct lesion of the spinal cord; if this were allowed, in view of the increase in tendon reflexes on the left leg and Achilles on the right, then it would be necessary to assume that the knife, penetrating the spinal canal on the left and injuring the roots of the left side, penetrated the substance of the brain, passing on the left and on its right side, which caused damage to the rights. pyramidal bundle and caused an increase in tendon reflexes not only on the left, but also on the right. With such a mechanism, however, a number of corresponding spinal symptoms would be observed, which was not the case. The increase in the mentioned reflexes could be explained, perhaps, by the pressure on the spinal cord of the hematoma.
Chronicle of the Society of Neurologists and Psychiatrists at the Imperial Kazan University of February 25, 1909
Authors: Darkshevich Liveriy O. , Pervushin Vsevolod P.
Published: March 2022

Presided over by prof. L. O. Darkshevich with the secretary Dr. V. P. Pervushin. Actions were present. members: prof. V. P. Osipov, N. A. Mislavsky, I. M. Dogel, V. F. Orlovsky, I. A. Chuevsky; Drs. N. A. Donskov, A. V. Favorsky I. A. Veselitsky, A. S. Segel, F. Ya. Kitaev, V. I. Nikolaev, M. A. Chalusov, G. I. Sorokovikov, A S. Sholomovich. Guests: Drs. N. E. Osokin, M. N. Cheboksarov, N. K. Goryaev, V. K. Voroshilov, S. A. Bolberg, I. I. Tsypkin, Shibkov, Lyubenetsky, Nikolskaya, Nikiforova, Bronnikov and up to 100 people predominantly medical students.

Real member A.V. Favorsky made a report: A case of syringobulbomyelia (with a demonstration of a patient from the clinic of nervous diseases of I.K.U.).
Diseases of the nervous system in the Russian army for 1891-1900
Authors: Sobolevsky A. V.
Published: March 2022

The proposed statistical study was compiled on the basis of annual reports on the sanitary condition of the Russian army, published by the Main Military Medical Directorate. Although these reports, in general, adhere to the same plan, yet some data are not indicated in all reports, which is why I had to resort to small calculations, guided by the testimony of the reports. All such and other newly obtained quantities are indicated in my tables in italics. Unfortunately, some cells of the tables were left blank due to the lack of relevant data.
R. M. Fronshtein. Trabecular bladder as one of the early symptoms of tabes. — Medical Review. 1910 № 9
Authors: Baklushinsky Ivan D.
Published: March 2022

Changes in the bladder mucosa, in the sense of the formation of ridges (trabeculae), due to hypertrophy of the bladder muscles, appear already in the very early period of tabes, when urination is not yet disturbed. The further the disease has gone, the more clearly these changes appear. The author confirms this in 18 cases of this disease during cystoscopy of the bladder of patients and concludes that the trabecular bladder is one of the earliest symptoms of tabes, and it is characterized by the location of the crossbars on the side walls of the bladder. Pure cases of tabes in various stages, without any purely urological diseases, were taken for the study.