bluuebunny/crossref_metadata_2025 huggingface dataset:
USE OF CYBER HATE IN THE ELECTORAL CAMPAIGNS BY THE MAINSTREAM POLITICAL PARTIES OF PAKISTAN
Authors: Siddiqua Ayesha
Published: April 2021

Purpose of the study: The purpose of the study is to examine the use of cyber hate by the Pakistan’s mainstream political parties. The issue of poll rigging in Pakistan’s General Elections 2013 is examined through discourse analysis of the related tweets. The study also aims at comprehending the extent to which cyber ethics were violated during the digital electoral campaigns.

Methodology: Discourse Analysis of the tweets generated from the official Twitter handles of PTI and PMLN leaders was conducted to examine the use of cyber hate by the Pakistan’s mainstream political parties. Violation of cyber ethics was explored through the qualitative interviews of 8 purposively selected social media managers of PMLN, PPP, and PTI.

Main Findings: The findings indicated that party leadership/politicians used the elements of cyber hate which included abusive language, provocation, and character assassination against their opponents during the digital electoral campaign in general and regarding the poll rigging issue of Pakistan’s General Elections 2013 in specific. Resultantly the tweets using strong adjectives and metaphors on the political opponents were more frequently re-tweeted and attracted more favorites.

Applications of this study: The study can be helpful in various cross-disciplinary areas that focus on the examination of the usage and impact of social media and cyberspace as a medium for hate speech dissemination. The study can significantly contribute to areas related to cyber ethics, digital electoral campaigning, freedom of expression, and political opinion building.

Novelty/Originality of this study: The study’s originality lies in its attempt to unfold the foundations of digital electoral campaigning in Pakistan and how cyberhate was used as a pivotal tool for advancing the political narratives in a fragile democratic society.
Trabalho Digital: o papel organizador da comunicação
Authors: Grohmann Rafael
Published: April 2021

O artigo lança bases teóricas para entender a área de trabalho digital desde a comunicação. Para isso, discute o processo de plataformização do trabalho para além da chamada “uberização” e com clivagens de raça, gênero, frações de classe e território. Considera as plataformas como meios de produção e comunicação, com lógicas de interações e processos produtivos desde suas arquiteturas. Assim, trata do papel da comunicação como organizadora do trabalho digital tanto no controle e gestão do trabalho nas plataformas quanto nas possibilidades de organização dos trabalhadores, seja em associações, sindicatos, cooperativas de plataformas ou arranjos mais informais.
Estudios de internet, comunicación y cultura digital en México
Authors: Flores-Márquez Dorismilda
Published: April 2021

Este artículo presenta una revisión de estudios sobre internet, comunicación y cultura digital, en México, durante el periodo 1981-2019, con el fin de identificar diferentes etapas, así como la presencia de rastros del pensamiento comunicacional latinoamericano y sus líneas derivadas. Para ello, se realizó una revisión de productos en CCDoc, una base de datos especializada en el campo de la comunicación en México. Se registraron 733 textos —libros, capítulos y artículos— y se hizo un análisis de contenido. Esto permitió identificar las principales temáticas e investigadores clave, las etapas en la investigación y los vínculos con el pensamiento comunicacional latinoamericano y otras tradiciones. Estos hallazgos desafían a otras generaciones de investigadores a reconocer las herencias y a contribuir al campo.
The user experience of personalized content
Authors: Mejtoft Thomas , Lindmark Tonje , Söderström Ulrik , Cripps Helen
Published: April 2021

Content in digital services is often filtered for users based on individual preferences with the possible consequence of creating a state referred to as a “filter bubble”. The objective of this paper is to examine which of a user’s inherent needs that are important to satisfy when a user is consuming personalized content in a digital service. The paper uses a survey to measure the need for autonomy, competence and relatedness of the SelfDetermination Theory when users are consuming filtered content in digital services. The results show that the investigated services fail to satisfy all needs. A satisfactory user experience should include the opportunity for the user to satisfy the need for autonomy, competence and relatedness. For autonomy, transparency of filtering and choice about filtering should be offered. For competence, it is essential to offer content that the user can learn from, and also provide the right amount of choice throughout the service. The danger of filter bubbles is not personalization, but to remove choice about personalization.
Conceptualizing the agile work organization: a systematic literature review, framework and research agenda
Authors: Greineder Michael , Blohm Ivo , Leicht Niklas
Published: April 2021

The ongoing discussion of the Agile Work Organization (AO) in research and practice permeates a multitude of research areas. However, no clear conceptualization of the AO has been provided. In this paper, we conduct a Systematic Literature Review to investigate what constitutes and defines the AO. The SLR reveals three dimensions in the research field of the AO: Strategic, Functional and Operative Agility. These dimensions define the AO through different unique capabilities by influencing and enhancing the overall goal of the AO in adaptation and flexibility. Building up on the insights from the review, we develop proposition which describe the interrelationship between the dimensions and towards the AO. Furthermore, implications for academia and practice as well as a research agenda are provided in order to trigger and guide further discussions and research surrounding the AO.
Agile leadership - a comparison of agile leadership styles
Authors: Greineder Michael , Leicht Niklas
Published: April 2021

Leadership has been the focus of research in the social sciences since the early 1930s. However, no generally valid theory exists to date. In recent years, theories relating to agile leadership have also increasingly emerged. The aim of this paper is to give an overview of the current state of research on agile leadership. For this purpose, a systematic literature analysis is conducted. The different terms used in the context of agile leadership are restricted by means of selection criteria. Furthermore, characteristics of agile leadership will be analyzed and consolidated. This results in a catalogue of criteria with which the selected leadership styles. The evaluation shows that there are overlaps in the styles, which also can be identified in the research.
Competing within aggregators: competitive moves in the Deliveroo Online delivery platform
Authors: Rodriguez Joaquin , Piccoli Gabriele
Published: April 2021

Aggregators are platforms that also control a marketplace for the suppliers’ innovations. Suppliers competing within aggregators are limited by the technology and governance rules of the platform owner. As a consequence, aggregators influence the type and complexity of competitive moves suppliers can implement. Our research investigates the drivers of suppliers’ competitive advantage. We incorporate existing literature on competitive action to identify the categories of moves available to suppliers. Furthermore, we identify three types of orthogonal moves that are unique to competition within aggregators. Finally, we illustrate our advanced categorization in the context of a major food delivery platform. Our preliminary results confirm that suppliers, while bounded to resources exposed by the aggregator, have the opportunity to implement an heterogenous portfolio of moves in their pursuit of competitive advantage. This result calls for empirical research in the context of competition within aggregators in general, and food delivery platforms specifically.
Life Stressors and Sleep Problems as Predictors of the Likelihood of Lifetime Cannabis Use among Black Adults with Criminal Justice Contact
Authors: Archibald Paul C. , Thorpe, Jr. Roland J.
Published: April 2021

Background: The criminal justice system is the second largest referral source to publicly funded marijuana use disorder treatment. Individuals with criminal justice contact (be­ing unfairly treated or abused by the police, lifetime arrest, incarceration, or parole) have reported notably high levels of stress, sleep problems, and marijuana use. There are well-known race and sex disparities in marijuana use and criminal justice contact. However, understanding is limited on the role that stressors and sleep problems con­tribute to marijuana use among Black adults who experience criminal justice contact.Objectives: To determine whether life stressors and sleep problems contribute to lifetime marijuana use among Black adults with criminal justice contact and if there are sex differences.Methods: We performed multivariate logis­tic analysis, using nationally representative data of a non-institutionalized population sample (n=1508) of the National Survey of American Life from 2001 to 2003. We compared life stressors and sleep problems between Black adults with criminal justice contact who had lifetime marijuana use and those who did not have lifetime marijuana use. All analyses were stratified by sex.Results: In the sample of Black males with criminal justice contacts, individuals who reported financial stress (PR: 1.34, 95% CI: 1.12-1.60) had a higher prevalence of experiencing lifetime marijuana use than Black males who reported no financial stress. Black males who reported that they were spiritual (PR: .76, 95% CI: .61-.93) had a lower prevalence of experiencing lifetime marijuana use than Black males who indicated that they were not spiritual. Black females who reported family stress (PR: 1.38, 95% CI: 1.04-1.82) had a higher prevalence of experiencing lifetime mari­juana use than Black females who reported no family stress.Conclusions: These results underscore the importance of considering sex differences in life stressors when developing etiologic models of marijuana use disorder for Black adults who have experienced criminal jus­tice contact.Ethn Dis. 2021;31(2):187-196; doi:10.18865/ed.32.1.187
A folyóirat recenzensei/lektorai 2016-ban
Authors: - -
Published: April 2021

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KAMPÁNYOPERETTBŐL TANULÓPÉNZ
Authors: KÉKESI KUN Árpád
Published: April 2021

A tanulmány a Fővárosi Operettszínház 1952-ben, Offenbach művének átirataként színre vitt Orfeusz-előadását elemzi a Philther-módszer szerint. Ennek megfelelően részletes tárgyalásra kerül a bemutató színházkulturális kontextusa, szöveg-, zene- és előadásdramaturgia-viszonya, a rendezés, a színészi játék, a színházi látvány és hangzás, valamint az előadás hatástörténete. A dolgozat célja egyrészt annak kimutatása, miért vált a táblás házakkal játszott produkció kritikai össztűz céltáblájává és a színháziak önértékelése szerint nyilvánvaló bukássá. Másrészt azon folyamat egy igen fontos állomásának (egy zsákutcának minősített próbálkozásnak a) körüljárása, ahogyan a rákosista diktatúrában a Gáspár Margit által vezetett budapesti intézmény alkotóközössége megtalálta az aktualizált, megújított szöveg és a muzsika közötti feszültség levezetésének, a klasszikus operettek politikai megfeleléskényszerből történő átírásának legideálisabb, a nem sokkal későbbi Luxemburg grófja és Csárdáskirálynő előadásaiban rendkívüli sikerre vitt módját.
REFERENCIÁLIS ÉS FIKTÍV MEZEI MÁRK
Authors: BENCE Erika
Published: April 2021

Mezei Márk Utolsó szombat című regényének cselekménye valóságos térben és időben, meglehetősen szűk keretek között játszódik: 1944. január 14-én, a budapesti Nagyatádi Szabó utca 32-es szám alatti lepusztult bérházban. Egyik szereplője, Áháron Rokéách belzi rabbi történelmi személyiség: ismertek életének referenciális vonatkozásai. A másik főszereplő, Adler Magda, fiktív személy – az ortodox zsidó vallási vezetővel ellentétben – asszimiláns családból származik, nem ismeri saját vallási hagyományait, biszexuális és alkoholista. Mindketten a lebukástól és a megsemmisüléstől való félelem kiváltotta szélsőséges magány állapotába kerülnek: a rabbi elhagyva a közösséget és hittársait árulóvá válik, míg Magda szerelmi árulás áldozatává lesz. Azonos léthelyzetbe, egymástól néhány méternyi közelségbe kerülnek: a félelem érzete azonban áthatolhatatlan falat von közéjük. Sohasem találkoznak. A dolgozat a narratíva motivikus és tropológiai vizsgálatára vállalkozik.
LEXIKAI INTERFERENCIAJELENSÉGEK A VAJDASÁGI MAGYAR NYELVBEN
Authors: ANDRIĆ Edit
Published: April 2021

Az interferencia fogalma a nyelvészetben azt a jelenséget nevezi meg, amikor két érintkező nyelv közül az egyik zavaró hatással van a másikra. Leginkább heterogén nemzeti és nyelvi közösségekben jelentkezik. Kezdetben az anyanyelv befolyásolja negatívan az idegen vagy környezetnyelv elsajátítását, később viszont a második nyelv hat vissza az anyanyelv használatára. Rendkívül fontos, hogy éppen Vajdaságban foglalkozzunk az interferencia jelenségével, és hogy folyamatosan figyeljük tendenciáit. A dolgozat a kisebbségi helyzetben levő vajdasági magyar nyelvet érő interferenciajelenségekről számol be, különös tekintettel a lexikai hatásokra. Ezúttal nem csak a szerb szavak mértéktelen beáramlásáról, adaptálásáról lesz szó, inkább a frazeológiai egységek tartalmi tükröztetéséről, valamint a már meglevő magyar szólások jelentésbővítéséről a szerb nyelv hatására.
TÁJKÉPET FESTŐ REGÉNY
Authors: NAGY Beáta
Published: April 2021

A XIX–XX. század fordulójának magyar irodalmát meghatározó kisregény megújulása lényegbevágó módon alakította át a korszak prózáját, több különböző típusú elbeszélésformát létrehozva, mely saját státusában teremti újjá a műfajt. Valamennyi kisregény (például Toldy István: Anatole, Asbóth János: Álmok álmodója, Reviczky Gyula: Apai örökség) jellemzően a szubjektum elbeszélhetőségének lehetőségeit kutatja, s ehhez a szövegegyütteshez sorolható a művészetet és a művészi létmódot kutató regénytípus is. A tanulmány az első magyar művészregény által felvetett problémakomplexum kérdéseivel foglalkozik. Justh Zsigmond Művészszerelem című regénye ugyanis a művészettel való találkozás során feltáruló érzelmi, hangulati tapasztalat nyelvi-szemantikai aspektusait mutatja fel a korszak jellegzetes képzőművészeti (impresszionista) eszméinek bevonásával.
KANONIZÁCIÓS STRATÉGIÁK – FORDÍTÁSIRODALMI KÉRDÉSKÖRÖK
Authors: FARAGÓ Kornélia
Published: April 2021

A tanulmány a modern jugoszláv elbeszélésirodalom közvetítését felvállaló fordításantológiák szerkesztési koncepcióit kutatva kérdez rá a hatvanas évek kanonizációs stratégiáinak működésmódjára. Számba veszi a szerb forráskultúra ideológiai alapon szerveződő kanonikus képződményeinek a behatolását a válogatói elképzelésekbe, a kánonátmentési törekvéseket, az áthelyeződéseket, a válogatásból kitagadott elbeszélői irányulásokat (Mai jugoszláv elbeszélők, 1960) és a kánonalakítási értelemben aktívabb kezdeményezéseket (Kísértő igazság: Mai jugoszláv elbeszélők, 1969) is, amelyek leginkább „a modern európai irodalom útjait” követő alkotókat kívánják antologikus keretekben elhelyezni.
Amount of salt (sodium chloride) per capita used in a Public Hospital Food Service in Natal, RN, Brazil
Authors: Sousa Bruno Jonatan de , Oliva Paula Angela Bessa Freitas de , Borges Thaís Araújo de Medeiros , Costa Valtêmia Porpino Gomes , Monteiro Carla Cristina
Published: April 2021

During 31 days, this study determined and evaluated the amount of salt (sodium chloride) per capita used in the preparation of the lunch meals in a public hospital food service in the City of Natal, RN, Brazil. The quantification of the salt was done through the weighing of the salt container in the beginning and at the end of lunch preparation. After that, the total amount found on each day was divided by the number of meals (750), and then the per capita amounts were compared to the maximum intake recomentation (5 g/day), and the maximum amount of salt estimated to be used for preparing lunch (2.5 g/day) in the food service studied, considering that this meal is planned to provide diners 50% of their caloric needs, even though the amount of salt used in the preparation of a meal does not necessarily represents the salt ingested, and plate waste should be considered as a modifying factor to salt intake. The results showed the per capita amounts of salt used for cooking lunch varied from 1.33 g to 5.87 g, and the average for the 31 days was 3.11 g. Only 14 days (45%) were under the limit line established for lunch. The lowest and highest results could be associated to cooking techniques and ingredients required in the menu. The findings of this study are important since they provide support to the implantation of a control system for the distribution of salt from the storeroom to the kitchen, as well as data to elaborate guiding material to food handlers, and also campaign material that can be used to sensitize both the food service team and dinners (employees, patients and patient companions) about the use and consumption of salt, helping to decrease the health risks associated to a high-sodium diet.
Estrategia metodológica para desarrollar el razonamiento clínico en los estudiantes de la carrera de terapia física y rehabilitación de una universidad privada de Lima
Authors:   , Calizaya Barrientos Angela Sofía
Published: April 2021

La investigación consistió en diseñar una estrategia metodológica para desarrollar el razonamiento clínico en estudiantes de la carrera de Terapia Física y Rehabilitación de una universidad privada de Lima Metropolitana. La metodología de estudio fue cualitativa con un enfoque de paradigma socio crítico e interpretativo de tipo aplicada educacional, cuyo diseño fue no experimental de corte transversal descriptivo. A partir de un muestreo de tipo no probabilístico e intencional se seleccionaron 13 estudiantes de ambos sexos y 4 docentes. Las técnicas empleadas fueron la aplicación de una guía de entrevista, un cuestionario y una prueba pedagógica. En el marco teórico, se recurrió a la teoría de Higgs (2008), Villagrán et al., (2018) para el razonamiento clínico y a Campusano y Díaz (2017) para la estrategia metodológica. Los resultados principales del trabajo de campo fueron la dificultad en el desarrollo de razonamiento clínico en los estudiantes, la necesidad de integración de conocimientos teóricos y prácticos, desconocimiento por parte de los docentes acerca de las estrategias metodológicas y pedagógicas. Como resultado se diseñó la estrategia metodológica aprendizaje de razonamiento clínico (ARC) adaptado a la pedagogía en fisioterapia, con este modelo se busca promover la integración de la teoría y práctica a través del estudio de casos clínicos, incentivar el análisis y la reflexión sobre lo aprendido revisando la evidencia científica sobre diversas patologías. Responde a un modelo de formación participativo basado en el modelo hipotético deductivo, este se realiza en determinado contexto en el cual se facilita la solución de problemas.
Surge Motion Passive Control of TLP with Double Horizontal Tuned Mass Dampers
Authors: Tabeshpour Mohammad Reza , Malayjerdi Ebrahim
Published: April 2021

The tension leg platform (TLP) is comprised of a buoyant hull that holds the platform's topside. A group of tendons under the columns connect the TLP to the foundation. The TLP is displaced in six degrees of freedom due to environmental loads. Tendons moor the TLP in vertical direction (heave and pitch). Surge amplitude (horizontal displacement) of TLP is greater than other degrees of freedom. Also heave motion is coupled with surge one. Therefore, it is important to introduce and implement a method to control and reduce displacement of the TLP in horizontal direction. In this paper, a passive control system (double horizontal tuned mass damper (TMD)) is used to mitigate the surge motion of TLP that is under regular waves. Also the efficiency and performance of double horizontal TMD and single horizontal TMD in reduction of surge response is compared.
Modelling and State Variable Feedback Control with Proportional Action of a One-Link Flexible Manipulator Incorporating Payload
Authors: Khairudin M. , Herlambang S. P. , Sigit Y. , Andik A. , Herawan T. , Mohamed Z. , Shah A. , Azman M. N. A.
Published: April 2021

This paper presents a state variable feedback (SVF) control with proportional gain to control a one-link flexible manipulator incorporating payload. The dynamic model of a one-link flexible manipulator is developed through a finite element method. The system is uncertain due to the variation of payloads and numbers of elements. There is a challenge in designing a controller for each number of elements. To obtain the effectiveness of the controllers, a combination of SVF control-based LQR controls with proportional gain is developed for a flexible link manipulator with payload variations. An assessment is conducted to examine the input tracking controller capability of the hub angular position, deflection, hub velocity and end-point residual of the one-link flexible manipulator. The responses of the system are shown in domains of time and frequency, while the SVF control with proportional gain schemes is also discussed. This study finds that the payload effects on the response incorporating payload with SVF control and proportional gain schemes can provide input tracking performance with zero steady state error.
Vibration Analysis of Rotating Wind Turbine Blades Based on Piezoelectric Materials
Authors: Jing Ben , Hao Wang
Published: April 2021

Piezoelectric materials have a piezoelectric effect that converts mechanical energy into electrical energy. In this paper, the blades of the rotating wind turbine are simplified as flexible beams fixed on the rotating wheels, and piezoelectric ceramics are added to the beams as sensors and actuators respectively to establish an analysis model of the vibration behavior of the piezoelectric sandwich rotating wind turbine blades. Based on Newton's second law, different accelerations are added to the rotating wheel to obtain the differential equation of a vibration variable coefficient. The fourth order Runge-Kutta method is used to solve variable coefficient differential equations. The hypothetical modal method is applied to solve the displacement of the free end of the flexible beam. A numerical simulation is also carried out to analyse the magnitude and change trend of the voltage output by adding piezoelectric materials at different angular velocities. The results show that the greater the rotational angular velocity, the greater the displacement of the free end of the flexible beam, and the greater the voltage due to the piezoelectric effect of the piezoelectric material. When the rotation angular velocity reaches a stable value, the displacement of the free end and the generated voltage will also reach a stable value.
Application of Statistical Energy Analysis (SEA) in Estimating Acoustic Response of Panels With Non-Uniform Mass Distribution
Authors: Renji K.
Published: April 2021

Statistical Energy Analysis (SEA) is generally used in estimating the responses of structures to high frequency acoustic excitation. Though it has been successfully applied for panels having uniform mass, its usage is limited when the mass distribution is not uniform, as seen in equipment panels of a spacecraft. Results for such panels are seldom reported. In this work, an attempt is made to address this gap. A methodology to estimate the responses of such panels in SEA framework is presented and demonstrated for an equipment panel of a spacecraft, thus widening its application. This is accomplished through SEA along with the information on the standing waves generated due to the change in the structural properties. The acceleration responses of a typical equipment panel when subjected to a diffused acoustic field in a reverberation chamber are measured. The responses of the same panel are theoretically estimated using the methodology presented and a reasonably good prediction is seen.
Engineering Project: The Method to solve practical problems for the monitoring and control of Driver-less Electric Transport Vehicles in the underground mines
Authors: Li Shuai , Wang Guojun , Yu Haoxuan , Wang Xinmin
Published: April 2021

With the continuous development of Artificial Intelligence technology and Internet of Things engineering, more and more driver-less vehicles have been developed and put into the industrial production. The birth of driver-less vehicles undoubtedly brings new vitality to a large amount of industries, particularly in transportation. For the mining industry, transportation is undoubtedly an extremely important link in the whole production process. If the driver-less vehicles can be applied to the underground mines, it can not only improve the production and transportation capacity of the whole mine, but also can reduce the occurrence of many mine safety accidents. ZigBee WSN technology can play a greater role in the narrow environment like underground mines according to the relevant literature, this concept paper just like a engineering project plan mainly tries to integrate the ZigBee WSN technology and the communication-based train control (CBTC) system to explore the possibility of the driver-less vehicles to be used in the underground mines, which aims to solve practical engineering problems for the engineering projects. As the mining engineers, we put forward the concept of this integrated system in this concept paper, but we need to continue to work hard for the future of the underground mines. This concept paper serves just as a guide to the Tossing out a brick to get a jade gem, has a few implications for the development of underground mine transportation.
Analysis and Forecasting the Precipitation and Temperature in the Dez Catchment Area
Authors: Chegnizadeh Alireza , Bahmani Mohammad Javad , Rabieifar3 Hamidreza , Ebrahimi Hossein
Published: April 2021

In this study, we have first studied the trend in meteorological data from the Harmaleh, Vanai and Farsesh stations in the 50-year period in the Dez catchment area. The meteorological data will be then forecasted using SWAT and Mann-Kendall. Forecasting the results in the Mann-Kendall and SWAT model has been done using the code written in MATLAB software and RCP (4.5, 8.5) scenarios, respectively. Studying the results of the trend in the data of meteorological stations in this catchment area indicated that these two parametric and non-parametric methods have been used to determine trends in meteorological data. The results of the parametric method are positive in all meteorological parameters. Non-parametric method over a period of 50 years shows the presence of trends in the data. The comparison on the forecasting results at maximum temperature suggested that during summer, we will see an increase in temperature compared to the ground state in all three forecasts. The results of the minimum temperature forecast show a decrease in the minimum increase during the winter and the precipitation forecast indicates that at the end of autumn (Nov) precipitation decreased by 20 mm in the Mann-Kendall and 4.5 RCP while RCP8.5 suggests the increase in precipitation compared to the ground state. Studying the runoff forecast results using SWOT show that at the end of winter (Feb) and almost all spring (Mar, Apr) a decrease of about 40%, 15% and 14% will be seen, respectively
SynPred: Prediction of Drug Combination Effects in Cancer using Full-Agreement Synergy Metrics and Deep Learning
Authors: Preto António J. , Matos-Filipe Pedro , Mourão Joana , Moreira and Irina S.
Published: April 2021

High-throughput screening technologies continues to produce large amounts of multiomics data from different populations and cell types for various diseases, such as cancer. However, analysis of such data encounters difficulties due to cancer heterogeneity, further exacerbated by human biological complexity and genomic variability. There is a need to redefine the drug discovery development pipeline, bringing an Artificial Intelligence (AI)-powered informational view that integrates relevant biological information and explores new ways to develop effective anticancer approaches. Here, we show SynPred, an interdisciplinary approach that leverages specifically designed ensembles of AI-algorithms, links omics and biophysical traits to predict synergistic anticancer drug synergy. SynPred exhibits state-of-the-art performance metrics: accuracy – 0.85, precision – 0.77, recall – 0.75, AUROC – 0.82, and F1-score - 0.76 in an independent test set. Moreover, data interpretability was achieved by deploying the most current and robust feature importance approaches. A simple web-based application available online at http://www.moreiralab.com/resources/synpred/ was constructed to predict synergistic anticancer drug combinations requiring only the upload of the two drug SMILES to be tested, allowing easy access by non-expert researchers.
Covid-19, Investor Sentiment and Contagion Across Stock Markets
Authors: BUĞAN Mehmet Fatih
Published: April 2021

This study examines investor sentiment which may trigger contagion in financial markets during the recent Covid-19 outbreak within a DCC-GARCH model. The results show that most of the time-varying correlations have risen after the Covid-19 outbreak until the WHO declared the disease as a global pandemic and most of the rise in correlations occurs within each group of countries/regions where the least and the most deaths took place. There is evidence of contagion in most cases. Overall, investor sentiment seems to give rise to contagion as the correlations between stock markets have increased during the global Covid-19 pandemic.
The Societal Value of Vaccination in the Age of COVID-19
Authors: Bloom David E. , Cadarette Daniel , Ferranna Maddalena
Published: April 2021

In recent years, academics and policymakers have increasingly recognized that the full societal value of vaccination encompasses broad health, economic, and social benefits beyond avoided morbidity and mortality due to infection by the targeted pathogen and limited health care costs. Nevertheless, standard economic evaluations of vaccines continue to focus on a relatively narrow set of health-centric benefits, with consequences for vaccination policies and public investments.

The COVID-19 pandemic illustrates in stark terms the multiplicity and magnitude of harms that infectious diseases may inflict on society. COVID-19 has overtaxed health systems, disrupted routine immunization programs, forced school and workplace closures, impeded the operation of international supply chains, suppressed aggregate demand, and exacerbated existing social inequities.

The obvious nature of the pandemic’s broad effects could conceivably convince more policymakers to identify and account for the full societal impacts of infectious disease when evaluating the potential benefits of vaccination. Such a shift could make a big difference in how we allocate societal resources in the service of population health and in how much we stand to gain from that spending.
COVID-19—The Case for Rethinking Health and Human Rights in Prisons
Authors: Pont Jörg , Enggist Stefan , Stöver Heino , Baggio Stéphanie , Gétaz Laurent , Wolff Hans
Published: April 2021

This article considers health and human rights implications for people deprived of liberty during the COVID-19 crisis. The health risks of incarceration for individual and community health, particularly in overcrowded and underresourced prisons and detention centers, are well known, but with the COVID-19 pandemic have become a public health emergency.

Physical distancing in prisons is hardly manageable, and protective means are poor or lacking. Emergency releases have been shown to be feasible in terms of public safety but lack sustainability in reducing the number of people living in detention, and, globally, only a small proportion of them have been released. Without controlling the infection inside prisons, global efforts to tackle the spread of the disease may fail. People living in detention are not only more vulnerable to infection with COVID-19 but they are also especially vulnerable to human rights violations induced by inappropriate restrictions under the pretext of infection control. Therefore, alternatives for detention should be promoted and the number of incarcerated people radically decreased.

This article calls on policymakers and all professionals involved in public health and criminal justice not to waste the opportunities provided by the crisis but to act now.
A framework for modeling and assessing system resilience using a Bayesian network : a case study of an interdependent electrical infrastructure systems
Authors: Hossain Niamat Ullah Ibne , Jaradat Raed , Hosseini Seyedmohsen , Marufuzzaman Mohammad , Buchanan Randy
Published: April 2021

This research utilizes Bayesian network to address a range of possible risks to the electrical power system and its interdependent networks (EIN) and offers possible options to mitigate the consequences of a disruption. The interdependent electrical infrastructure system in Washington, D.C. is used as a case study to quantify the resilience using the Bayesian network. Quantification of resilience is further analyzed based on different types of analysis such as forward propagation, backward propagation, sensitivity analysis, and information theory. The general insight drawn from these analyses indicate that reliability, backup power source, and resource restoration are the prime factors contributed towards enhancing the resilience of an interdependent electrical infrastructure system.
Full-fledged gene-editing payload for AAV delivery built on guide RNA-remodeled miniature type V-F CRISPR
Authors: Kim Yong-Sam , Kim Do Yon , Lee Jeong Mi , Moon Su Bin , Chin Hyun Jung , Park Seyeon , Lim Youjung , Ko Jeong-Heon
Published: April 2021

The authors have requested that this preprint be removed from Research Square.
The Binding Characteristics of Sediment-Derived Dissolved Organic Matter with Ceftazidime: A Microstructural and Spectroscopic Correlation Study
Authors: Cai Xuewei , Qi Kemin , Zhang Xiaoli , Xie Xiaoyun , Wang Zhaowei
Published: April 2021

This research focused on the characterization of sediment-derived DOM (SDOM) extracted from sediment of Yellow River and the binding behaviors of ceftazidime (CAZ) with the presence of SDOM. The morphology, surface composition and structure of SDOM and the complexation between SDOM and CAZ in terms of component features, binding capacity and sequence were studied by multiple approaches. Results showed that SDOM was in situ autochthonous-dominated with a low weight-average molecular weight and aromaticity. The multiple morphological characteristics, high surface oxygen contents (53.49%) and more aliphatic of SDOM were further confirmed. Studies on SDOM-CAZ interaction suggested that the functional groups and chemical compositions of SDOM were susceptible to CAZ. In more detail, the aromatic protons and aliphatic protons of CAZ impacted significantly and the binding between CAZ and SDOM might relate to noncovalent. The protein-like fractions were considered to primary participant and the aromatics and amides as mainly active sites interaction with CAZ. These findings have significant implications on the environmental fate of cephalosporin antibiotics and that of sediment-derived DOM.
Effect of Laser surface texturing on coating adherence and tribological properties of CuNiIn and MoS2 coating
Authors: Bagade Vishal Uttamra , Duraiselvam Muthukannan , Sarangi Niranjan , K Parthiban
Published: April 2021

In aero gas turbine engine, copper nickel indium (CuNiIn) and molybdenum loaded disulphide (MoS2) duplex coating is applied on Ti6Al4V blades in bladed disk configuration of low pressure and high pressure compressor. Coating between blade and disk is provided to prevent fretting wear due to direct metal to metal contact of Ti6Al4V. Generally, grit blasting will be done for preparation of the surface before the application of coating. Laser surface texturing (LST) process can be explored by aero engine industry as a new surface preparation process for compressor blades. To compare two different surface preparation methods, Ti6Al4V surface is prepared by two different processes, conventional grit blasting as well as laser surface texturing (LST). LST with different elliptical and square patterns are created on Ti6Al4V. Surface topography is analyzed by SEM and WLI. CuNiIn is sprayed by atmospheric plasma spray (APS) and MoS2 on top of CuNiIn by painting and curing. Effects of surface preparation on coating adherence as well as on tribological properties are studied. The results showed that geometry and dimensions of LST pattern influences the coating adherence and wear performance. LST process can be optimized for better performance and explored as an alternative surface preparation process in industry for thermal spray coatings.
A Lean & Green approach for the ecoefficiency assessment on construction sites: description and case study
Authors: Rezende Marilia de Oliveira , Saade Marcella Ruschi Mendes , Nunes Andréa Oliveira , Silva Vanessa Gomes da , Moris Virgínia Aparecida Silva , Silva Diogo Aparecido Lopes
Published: April 2021

Lean and Green seeks to increase added value and reduce waste generation, while also improving environmental sustainability performance in production activities. However, no studies were found exploring the potential results by combining Lean and Green with eco-efficiency assessments in the construction sector. Therefore, this paper aimed at proposing and testing a Lean and Green approach in three steps. Step 1 was based on the Value Stream Mapping application to calculate the Value Added of construction activities; step 2 focused on the Life Cycle Assessment of evaluated construction activities, and step 3 performed an eco-efficiency assessment of construction sites to guide decision-makers on selecting more lean and sustainable construction materials and strategies. A case study was developed for a 300m²-house construction considering two build options (reinforced concrete frame vs. light steel frame). The results affirm that light steel framing showed a Value Added 43% higher than the reinforced concrete in step 1, whilst having 8% less Global Warming Potential impacts in step 2. Step 3 concluded that light steel framing was 1.38 times more eco-efficient than the concrete structure. The proposed approach can be suitable for any building system evaluation in terms of construction technologies, materials, and/or production strategies and investigations towards more sustainable production.
Devosia Sediminis sp. nov., Isolated from Fubterranean Sediment.
Authors: Ma Fu , Zi Da Zhi , Li Wei , Wang Zhao Xuan , Lu Jun , Lv Jie
Published: April 2021

A novel Gram- negative, cream-colored, rod-shaped, aerobic, non-motile bacterium, designated MSA67T, was isolated from a subterranean sediment sample of the Mohe Basin in Northeast China. Strain MSA67T was detected to grow at 4–40°C (optimum, 28–30°C), pH 5.0–10.0 (optimum, pH 7.0) and in 0.0–8.0 % (w/v) NaCl (optimum, 2.0–3.0 %). Phylogenetic analysis based on 16S rRNA gene sequence revealed that strain MSA67T was a member of the genus Devosia, with the highest similarity with D. riboflavina IFO13584T (98.0 %) and D. chinhatensis IPL18T (97.0 %). The major cellular fatty acids are C16:0, C18:1ω7c 11-methyl and C18:1ω6c and/or C18:1ω7c. The major polar lipids are diphosphatidylglycerol, phosphatidylglycerol, glycolipids and three unidentified phospholipids. The major respiratory quinone is ubiquinone 10 (Q-10). The genomic size of strain MSA67T is 4.1 MB and DNA G + C content is 63.6 %. Based on genotypic, phenotypic and phylogenetic results, strain MSA67T is concluded to represent a novel species of the genus Devosia, for which the name Devosia sediminis sp. nov. is proposed. The type strain is MSA67T (= CGMCC 1.18467T = KCTC 82192T).
Knockdown of TRIM44 inhibits the progression of human epithelial ovarian cancer via the FOXM1-EZH2 signaling pathway
Authors: Meng Fanling , Ding Jing , Chen Xihai , Sui Lin , Hu Yuanlong , Liu Shuang , Shi Guangyue , He Yunlong , Ning Xin , Zhu Jiaqi , Zhao Ruixue , Ma Jing , Ren Sujing , Ma Rong , Huang Ning
Published: April 2021

Background. Tripartite motif‑containing protein 44 (TRIM44) was recently identified as a novel oncogene that is overexpressed in several types of human cancers. However, the biological functions of TRIM44 in epithelial ovarian cancer (EOC) remain unclear. Here, we aimed to investigate the role of TRIM44 in EOC and its clinical implications.Methods. The expression of TRIM44 in different ovarian cancer cell lines were detected by western blot. TRIM44 was knocked down by shRNA transfection. The in vitro proliferation, invasion, migration and apoptosis of ovarian cancer cells were detected by CCK8, colony formation assay, transwell filters, tube formation assay and flow cytometry analysis, respectively. The growth ability of xenograft tumors in vivo was examined by a nude mouse metastatic tumor model. Finally, we carried out gene chip analysis and IPA to analyze the potential gene network.Results. High expression of TRIM44 was observed in EOC tissues and cell lines. Knockdown of TRIM44 expression substantially suppressed the proliferation, migration, invasion and colony-forming ability of EOC cells in vitro and attenuated tumor growth in vivo. Mechanistic studies showed that silencing TRIM44 dramatically down regulated the expression of FOXM1, EZH2, CCNE2, CCND3 and BIRC5 in EOC cells, at least in part through inactivation of the FOXM1-EZH2 signaling pathway.Conclusion. Collectively, these data suggest that TRIM44 downregulation inhibits the progression of EOC cells through the suppression of the FOXM1-EZH2 signaling pathway. These results provide novel insight into the role of TRIM44 in tumorigenesis and suggest it could be a potential therapeutic target of ovarian carcinoma.
Establishment of An Orthotopic Prostate Cancer Xenograft Mouse Model Using Microscope-Guided Orthotopic Injection of LNCaP Cells Into The Dorsal Lobe of The Mouse Prostate
Authors: Liu Weiyong , Zhu Yunkai , Ye Lei , Zhu Yajuan , Wang Yuhao
Published: April 2021

Background: Orthotopic LNCaP xenograft mouse models closely mimic the progression of androgen-dependent prostate cancer in humans; however, orthotopic injection of LNCaP cells into the mouse prostate remains a challenge.Methods: Under the guidance of a stereoscopic microscope, the anatomy of the individual prostate lobes in male Balb/c athymic nude mice was investigated, and LNCaP cells were inoculated into the mouse dorsal prostate (DP) to generate orthotopic tumors that mimicked the pathophysiological process of prostate cancer in humans. Real-time ultrasound imaging was used to monitor orthotopic prostate tumorigenesis, contrast-enhanced ultrasonography (CEUS) was used to characterize tumor angiogenesis, and macroscopic and microscopic characteristics of tumors were described.Results: The DP had a trigonal bipyramid-shape and were located at the base of the seminal vesicles. After orthotopic inoculation, gray scale ultrasound imaging showed progressive changes in tumor echotexture, shape and location, and tumors tended to protrude into the bladder. After 8 weeks, the tumor take rate was 65% (n= 13/20 mice). On CEUS, signal intensity increased rapidly, peaked, and decreased gradually. Observations of gross specimens showed orthotopic prostate tumors were well circumscribed, round, dark brown, and soft, with a smooth outer surface and a glossy appearance. Microscopically, tumor cells were arranged in acini encircled by fibrous septa with variably thickened walls, mimicking human adenocarcinoma.Conclusions: This study describes a successful approach to establishing an orthotopic LNCaP xenograft Balb/c athymic nude mouse model. The model requires a thorough understanding of mouse prostate anatomy and proper technique. The model represents a valuable tool for the in vivo study of the biological processes involved in angiogenesis in prostate cancer and preclinical evaluations of novel anti-angiogenic therapies.
Mitofusin 1 and 2 regulation of mtDNA content is a critical determinant of glucose homeostasis
Authors: Sidarala Vaibhav , Zhu Jie , Pearson Gemma , Reck Emma , Kaufman Brett , Soleimanpour Scott
Published: April 2021

The dynamin-like GTPases Mitofusin 1 and 2 (Mfn1 and Mfn2) are essential for mitochondrial function, which has been principally attributed to their regulation of fission/fusion dynamics. Here, we report that Mfn1 and 2 are critical for glucose-stimulated insulin secretion (GSIS) primarily through control of mtDNA content. Whereas Mfn1 and Mfn2 individually were dispensable for glucose homeostasis, combined Mfn1/2 deletion in β-cells reduced mtDNA content, induced mitochondrial fragmentation, and impaired respiratory function, ultimately resulting in severe glucose intolerance. Importantly, gene dosage studies unexpectedly revealed that Mfn1/2 control of glucose homeostasis was dependent on maintenance of mtDNA content, rather than mitochondrial structure. Indeed, pharmacologic mitofusin agonists rescued islet mtDNA depletion due to mitofusin deficiency independent of changes on mitochondrial structure. Mfn1/2 maintain mtDNA content by regulating the expression of the crucial mitochondrial transcription factor Tfam, as Tfam overexpression ameliorated the reduction in mtDNA content and GSIS in Mfn1/2-deficient β-cells. Thus, the primary physiologic role of Mfn1 and 2 in β-cells is coupled to preservation of mtDNA content rather than mitochondrial architecture, and Mfn1 and 2 may be promising targets to overcome mitochondrial dysfunction and restore glucose control in diabetes.
Study on the Effect of Surface Subsidence Due to Tunneling Under Various Loading Conditions
Authors: KRISHNA SOMU S , Lokhande Ritesh D
Published: April 2021

The subsidence caused on the surface due to the construction of subsurface tunnels for various purposes in urban areas is a major concern for both the tunnel and the overlaid buildings. Seeing the importance of study, different models has been created keeping reference of commercial and residential buildings. The amount of surface deformation and the stresses so generated are calculated, which plays a paramount role before construction. These models are analyzed on circular and semicircular tunnels with various loading conditions and varying litho. In this paper, two software’s namely STAAD Pro and Rocscience were used for structural design and analysis respectively. The study gives the basic idea of behavior of these two shapes of tunnels with varying loading condition and strata which shows a path for predicting unforeseeable displacements in real life situations.
Xylose Release From Sunflower Stalk by Coupling Autohydrolysis and Enzymatic Post-Hydrolysis
Authors: HALICI-DEMİR Fatmagül , AKPINAR Özlem
Published: April 2021

The purpose of this study was to obtain xylose-based fermentation media from autohydrolysis liquors of sunflower stalk by using commercial xylanase formulation. Xylose is generally produced from xylan by diluted acid hydrolysis that causes the formation of some unwanted compounds during the process. As an alternative to dilute acid hydrolysis method, enzymatic hydrolysis of xylan can provide more specific hydrolysis under moderate conditions and does not cause the formation of undesirable compounds. In this study, xylose production carried out with Trichoderma longibrachiatum xylanase on solubilized xylan form of sunflower stalk, which was hydrothermally pretreated for 1 hour at 160ºC. The effects of substrate concentration and enzyme activity were investigated for the production of xylose. To obtain a high xylose yield and selectivity, the optimization study was conducted by the response surface methodology. The optimum substrate concentration and enzyme activity were found as 60 mg ds/mL CAL and 234 U/mL, respectively. Under the optimum condition, xylose yield and selectivity were found to be 69.5% and 8.2 g/g, respectively. This study showed that xylose could be produce with a high yield without requiring a neutralization process and corrosive chemical reagent apart from water.