bluuebunny/crossref_metadata_2025 huggingface dataset:
Good complaints handling in general practice
Authors: Taylor Terri Bonnici Sue
Published: February 2020

As a new year of challenges sets in for practice managers there will almost always be complaints to handle. Terri Bonnici and Sue Taylor discuss ways complaints can be prevented, managed, and used as an opportunity to make improvements
Supporting families with genetic conditions
Authors: Noakes Amy
Published: February 2020

Health professionals in primary care have a fundamental role in supporting families with a genetic condition to encourage physical and emotional wellbeing, says Amy Noakes
La idea de participació en el reglament de minibàsquet: anàlisi conceptual i proposta pedagògica.
Authors: Valenciano Oller Mauro
Published: February 2020

There is currently a trend to see the rewriting of sports rulebooks as almost the only way to remedy perceived imperfections in the youth sport system. The trend can be seen in many sports programmes and has generated heated debate. The article adds to the debate by analysing a proposal to review the Catalan Basketball Federation’s regulations for biddy basketball, and it puts forward a pedagogical proposal comprising two objectives: to identify the aspects that define the idea of participating in this particular area of the youth sport system, and to understand the role of technique in the biddy basketball rule book. At a philosophical level, the article also identifies the main factors that ensure players improve their game technically. Finally, going beyond biddy basketball as such, the article suggests how to improve youth sport at an organizational level and in technical and pedagogical terms.
Automated single cardiomyocyte characterization by nucleus extraction from dynamic holographic images using a fully convolutional neural network
Authors: Ahmadzadeh Ezat , Jaferzadeh Keyvan , Shin Seokjoo , Moon Inkyu
Published: February 2020

Human-induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs) beating can be efficiently characterized by time-lapse quantitative phase imaging (QPIs) obtained by digital holographic microscopy. Particularly, the CM’s nucleus section can precisely reflect the associated rhythmic beating pattern of the CM suitable for subsequent beating pattern characterization. In this paper, we describe an automated method to characterize single CMs by nucleus extraction from QPIs and subsequent beating pattern reconstruction and quantification. However, accurate CM’s nucleus extraction from the QPIs is a challenging task due to the variations in shape, size, orientation, and lack of special geometry. To this end, we propose a novel fully convolutional neural network (FCN)-based network architecture for accurate CM’s nucleus extraction using pixel classification technique and subsequent beating pattern characterization. Our experimental results show that the beating profile of multiple extracted single CMs is less noisy and more informative compared to the whole image slide. Applying this method allows CM characterization at the single-cell level. Consequently, several single CMs are extracted from the whole slide QPIs and multiple parameters regarding their beating profile of each isolated CM are efficiently measured.
Meta-hologram-based authentication scheme employing a speckle pattern fingerprint
Authors: Blau Y. , Bar-On O. , Hanein Y. , Boag A. , Scheuer J.
Published: February 2020

A concept for an optical holographic security tag is proposed and demonstrated. When illuminated with a laser beam, the image scattered from the tag projects a Quick Response code which encodes identifying information. The image also carries pseudorandom speckle noise, from which a unique speckle pattern “fingerprint” is derived. We show numerically that the tag is unclonable without access to a secret key - the starting conditions of the design algorithm. However, given the key, it is straightforward to reproduce a tag exhibiting the expected fingerprint. Several tags have been realized, implemented as plasmonic meta-holograms, and characterized experimentally. The robustness of the tag to fabrication error and its resilience to counterfeiting are studied in detail and demonstrated experimentally.
Wahrnehmung von Technik und Digitalisierung in Deutschland und Europa: Befunde aus dem TechnikRadar
Authors: Störk-Biber Constanze , Hampel Jürgen , Kropp Cordula , Zwick Michael
Published: February 2020

Der vorliegende Beitrag stellt die Wahrnehmung von Technik und Digitalisierung in Deutschland und im Vergleich mit dem europäischen Ausland dar. Er geht auf die Ergebnisse des TechnikRadar aus den Jahren 2018 und 2019 zurück. Das TechnikRadar von acatech – Deutsche Akademie der Technikwissenschaften und Körber-Stiftung beleuchtet jährlich mit verschiedenem Fokus, was die Deutschen über Technik denken. Erstellt und wissenschaftlich ausgewertet wird es von den AutorInnen des Beitrags. 2018 und 2019 standen die Wahrnehmung und Bewertung der Digitalisierung im Mittelpunkt, wobei 2018 die Ergebnisse der Repräsentativbefragung in Deutschland vorgestellt und 2019 diese Ergebnisse sowohl einer vertiefenden Analyse zu alters- und geschlechtsspezifischen Unterschieden unterzogen als auch mit Befunden aus anderen internationalen Studien verglichen wurden. Anhand von Anwendungsfeldern wie dem autonomen Fahren, Pflegerobotik, Smart Home und der Digitalisierung von Infrastrukturen wird herausgestellt, wie Technik in den jeweiligen Kontexten wahrgenommen und welche Chancen und Risiken gesehen werden. Dabei zeigt sich, dass die eigene Kompetenzwahrnehmung in Bezug auf den Umgang mit digitalen Technologien und Diensten sowie das Vertrauen der Menschen in die Akteure der Digitalisierung wesentlich für eine grundlegende gesellschaftliche Akzeptanz von Digitalisierungsprozessen ist.
Detection of antibiotic-resistant bacteria and their resistance genes from houseflies
Authors: Akter Sharmin , Sabuj Abdullah Al Momen , Haque Zobayda Farzana , Rahman Md. Tanvir , Kafi Md. Abdul , Saha Sukumar
Published: February 2020

Background and Aim: Houseflies (Musca domestica) are synanthropic insects which serve as biological or mechanical vectors for spreading multidrug-resistant bacteria responsible for many infectious diseases. This study aimed to detect antibiotic-resistant bacteria from houseflies, and to examine their resistance genes. Materials and Methods: A total of 140 houseflies were captured using sterile nylon net from seven places of Mymensingh city, Bangladesh. Immediately after collection, flies were transferred to a sterile zipper bag and brought to microbiology laboratory within 1 h. Three bacterial species were isolated from houseflies, based on cultural and molecular tests. After that, the isolates were subjected to antimicrobial susceptibility testing against commonly used antibiotics, by the disk diffusion method. Finally, the detection of antibiotic resistance genes tetA, tetB, mcr-3, mecA, and mecC was performed by a polymerase chain reaction. Results: The most common isolates were Staphylococcus aureus (78.6%), Salmonella spp., (66.4%), and Escherichia coli (51.4%). These species of bacteria were recovered from 78.3% of isolates from the Mymensingh Medical College Hospital areas. Most of the isolates of the three bacterial species were resistant to erythromycin, tetracycline, penicillin and amoxicillin and were sensitive to ciprofloxacin, ceftriaxone, chloramphenicol, gentamicin, and azithromycin. Five antibiotic resistance genes of three bacteria were detected: tetA, tetB, mcr-3, and mecA were found in 37%, 20%, 20%, and 14% isolates, respectively, and no isolates were positive for mecC gene. Conclusion: S. aureus, Salmonella spp., and E. coli with genetically-mediated multiple antibiotic resistance are carried in houseflies in the Mymensingh region. Flies may, therefore, represent an important means of transmission of these antibiotic-resistant bacteria, with consequent risks to human and animal health.
Treatment of Chronic Abdominal Pain With 10-kHz Spinal Cord Stimulation: Safety and Efficacy Results From a 12-Month Prospective, Multicenter, Feasibility Study
Authors: Kapural Leonardo , Gupta Mayank , Paicius Richard , Strodtbeck Wyndam , Vorenkamp Kevin E. , Gilmore Christopher , Gliner Bradford , Rotte Anand , Subbaroyan Jeyakumar , Province-Azalde Rose
Published: February 2020

INTRODUCTION:

Chronic abdominal pain (CAP) can arise from multiple conditions, including inflammatory disorders, trauma because of injury or surgery, or structural or functional causes. This prospective, single-arm study was designed to evaluate the safety and efficacy of 10-kHz spinal cord stimulation (SCS) in patients with intractable CAP over a 12-month follow-up period.

METHODS:

Subjects with CAP who had been refractory to conventional medical treatment for at least 3 months resulting in self-reported pain scores of ≥5 cm on a 10-cm visual analog scale were enrolled at 4 centers in the United States. Study subjects underwent a trial stimulation lasting up to 14 days with epidural leads implanted from the vertebral levels T4 through T8. Subjects who had ≥40% pain relief during the trial stimulation period were implanted with a Senza system (Nevro Corp., Redwood City, CA) and followed up to 12 months after surgery.

RESULTS:

Twenty-three of 24 subjects (95.8%) had a successful trial stimulation and proceeded to a permanent implant. After 12 months of treatment with 10-kHz SCS, 78.3% of subjects were responders (pain relief of ≥50%) and 14 of 22 subjects (63.6%) were remitters (sustained ≤3.0-cm visual analog scale scores). Secondary outcomes, including assessments of disability, mental and physical well-being, sleep quality, perception of improvement, and satisfaction, showed that 10-kHz SCS greatly improved the quality of life of patients with CAP. Observationally, most subjects also reported concurrent reduction or resolution of nausea and/or vomiting.

DISCUSSION:

10-kHz SCS can provide durable pain relief and improve the quality of life in patients with CAP.
El proceso de duelo desde la Terapia Familiar Sistémica: el papel del apego adulto
Authors: García Torres Rocío
Published: February 2020

El objetivo del trabajo que se propone es realizar una investigación en torno a la bibliografía existente sobre el proceso de duelo en el contexto de la terapia familiar sistémica, con el fin de estudiar qué peso tienen variables como el apego, el sistema de creencias familiar. No hay dos procesos de duelo iguales ni dos familias que vivan esta situación de la misma manera, por ello, a la hora de abordar terapéuticamente la pérdida de un ser querido, es necesario atender a sus diferencias culturales, a su sistema de creencias característico, y a las posibles disfunciones que pudieran preexistir
Estudo de atividade antimicrobiana de 3,4-(metilenodióxi)-acetofenona
Authors: Diniz Neto Hermes , Nóbrega Jefferson , Duarte Gabrielly , Borges Flávio , Barbosa Filho José , Rodrigues Luis , De Oliveira Filho Abrahão , Lima Edeltrudes
Published: February 2020

A crescente incidência de infecções por bactérias e fungos têm preocupado diversos órgãos de saúde ao redor do mundo. Entre as infecções mais prevalentes estão as bacterianas, causadas por Staphylococcus aureus e Pseudomonas aeruginosa, e infecções fúngicas como candidíase e aspergilose. A farmacoterapia utilizada nos casos de infecção normalmente apresenta toxicidade indesejada e hoje em dia já começa a falhar ao não obter êxito diante de cepas resistentes. Esta realidade gera a necessidade crítica de desenvolvimento de novas estratégias para o combate destas infecções de elevadas taxas de mortalidade. A 3,4-(metilenodióxi)-acetofenona (EPHO) é um produto químico da classe das acetofenonas, facilmente adquirido comercialmente e amplamente utilizado em reações de síntese química. Contudo, ainda não é apropriadamente explorada quanto ao seu potencial antimicrobiano. Para avaliar o perfil antimicrobiano da substância, a concentração inibitória mínima (CIM) foi determinada contra cepas bacterianas e fúngicas envolvendo tanto leveduras quanto fungos filamentosos. Foi observado que, apesar do produto se mostrar inerte contra bactérias, ele apresentou atividade inibitória contra algumas cepas de fungos leveduriformes e filamentosos com CIM respectivas de 1024 e 512 µg/mL.
„Binnenmarkt für Philanthropie - Programm für eine europäische Stiftungspolitik“
Authors: Oldenburg Felix , von Abendroth Max
Published: February 2020

Wenn eine deutsche gemeinnützige Stiftung ein griechisches Flüchtlingscamp mit Fördermitteln unterstützen möchte, bedeutet das in rechtlicher Hinsicht, Formen der Steuerbegünstigung unterschiedlicher Länder gleichzeitig zu managen. Das ist verbunden mit hohem administrativem Aufwand. Was fehlt, ist ein „Binnenmarkt für Philanthropie“. Dieser Beitrag befasst sich mit der Frage, warum ein europäischer Binnenmarkt für Philanthropie wichtig ist und was die europäische Stiftungswelt mit dem „European Philanthropy Manifesto“ (20. März 2019) fordert.
Heat shock protein 60 is a disease-associated sialoglycoprotein in human non-small cell lung cancer
Authors: Singh Praveen , Kumari Munmun , Bal Amanjit , Srinivasan Radhika , Ghosh Sujata
Published: February 2020

The diagnostic and therapeutic potential of Maackia amurensis agglutinin (MAA) have been reported in various malignancies. Earlier, we have found that MAA specifically interacted with human non-small cell lung-cancer (NSCLC) cells and induced apoptosis in these cells. The present study was designed to identify M. amurensis leukoagglutinin (MAL-I, one of the components of MAA, having the same carbohydrate specificity as MAA) interacting membrane sialoglycoprotein(s) of two subtypes of human NSCLC cell lines. Nine proteins were identified using two-dimensional (2D)-polyacrylamide gel electrophoresis (PAGE) followed by MAL-I-overlay transblotting and matrix assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF-MS). Among these proteins, HSP60 was selected for further characterization. The sialoglycoprotein nature of membrane-HSP60 of NSCLC cell lines was confirmed by its reduced reactivity with MAL-I in Western blots in the presence of GM2 and by dual staining of the cell lines with MAL-I and HSP60-antibody. These findings were further substantiated by enzymatic analysis of membrane-HSP60 as well as in-silico evidence regarding this protein. Our observations were validated by immunohistochemical analysis of both subtypes of NSCLC tissue sections. Membrane-HSP60 was found to be involved in the inhibition of MAL-I-induced morphological alteration of NSCLC cells and also in the proliferation and migration of these cells, indicating the probable role of sialylated membrane-HSP60 in this disease.
The Effect of Temperature Change on the Output Characteristics of a Solar Power Plant under Partial Shading Conditions
Authors: Kievets Anton , Bay Julius , Suvorov Aleksey , Askarov Alisher , Rudnik Vladimir
Published: February 2020

Currently, the world is widely introducing renewable energy sources including solar power plants (SPP). In order to predict their work, it is necessary to adequately simulate the processes occurring in solar panels, not only in standard conditions, but also in conditions of partial shading. At present, the effect of partial shadowing is considered from the point of view of changes in the luminous flux, however, for a more adequate and comprehensive simulation, it is also necessary to take into account the temperature change in the shaded areas of SPP, especially considering the area of powerful SPP, the temperature of individual sections of which can radically differ, which is undoubtedly will lead to a change in the output characteristics of the SPP. Failure to take this factor into account, when modeling high-power SPP leads to results that do not correspond to real data.
Observation of an exceptional point in a non-Hermitian metasurface
Authors: Park Sang Hyun , Lee Sung-Gyu , Baek Soojeong , Ha Taewoo , Lee Sanghyub , Min Bumki , Zhang Shuang , Lawrence Mark , Kim Teun-Teun
Published: February 2020

Exceptional points (EPs), also known as non-Hermitian degeneracies, have been observed in parity-time symmetric metasurfaces as parity-time symmetry breaking points. However, the parity-time symmetry condition puts constraints on the metasurface parameter space, excluding the full examination of unique properties that stem from an EP. Here, we thus design a general non-Hermitian metasurface with a unit cell containing two orthogonally oriented split-ring resonators (SRRs) with overlapping resonance but different scattering rates and radiation efficiencies. Such a design grants us full access to the parameter space around the EP. The parameter space around the EP is first examined by varying the incident radiation frequency and coupling between SRRs. We further demonstrate that the EP is also observable by varying the incident radiation frequency along with the incident angle. Through both methods, we validate the existence of an EP by observing unique level crossing behavior, eigenstate swapping under encirclement, and asymmetric transmission of circularly polarized light.
Crystal structure of bis[(μ2-4⋯O,O′:O′)-(4-hydroxybenzoato-κ2
O,O′)-(1,10-phenanthroline-κ2
N,N′)]-di-lead(II)μ-4-hydroxybenzoato-κ3
O,O′:O′;κ3
O,O′:O′-bis-[(4-hydroxybenzoato-κ2
O,O′)bis(1,10-phenanthroline-κ2
N,N′)di-lead(II)] monohydrate, C52H36N4O12Pb2 ⋅ H2O
Authors: Dai Ben-Cai , Liu Chang-Chun , Zhou Yang , Chen Jin , Fu Yang , Zhao Pei-Zheng
Published: February 2020

C52H36N4O12Pb2 ⋅ H2O, monoclinic, P21/n (no. 19), a = 13.7767(1) Å, b = 7.9925(1) Å, c = 21.2490(2) Å, β = 93.1490(10)°, V = 2336.20(4) Å3, Z = 4, R
gt(F) = 0.0220, wR
ref(F
2) = 0.0582, T = 170 K.
A bioinspired strategy for poly(3,4-ethylenedioxypyrrole) films with strong water adhesion
Authors: Sathanikan Ananya , Guittard Frédéric , Darmanin Thierry
Published: February 2020

Using a bioinspired approach, we prepare poly(3,4-ethylenedioxypyrrole) (PEDOP) films with parahydrophobic properties, characterized by high apparent water contact angle and strong water adhesion. The films are made by electropolymerization and the influence of substitution by an alkyl chain of various length (from C4H9 to C14H29) on the 3,4-ethylenedioxy-bridge is reported. More precisely, the best properties are obtained from a length of C12H25 due to the formation of spherical nanoparticles.
Öffentliche Investitionen: Die Schuldenbremse ist nicht das Problem
Authors: Feld Lars P. , Reuter Wolf Heinrich , Yeter Mustafa
Published: February 2020

Es gibt öffentlichen Investitionsbedarf in Deutschland, zum Beispiel zur Bewältigung des Strukturwandels, im Rahmen der Klimapolitik oder mit Blick auf die öffentliche Infrastruktur. Die genaue Höhe dieses Bedarfs ist jedoch äußerst unsicher. Einer Erhöhung der Investitionen stehen die ausgelasteten Kapazitäten in der Bauwirtschaft und den Planungsämtern, kommunale Finanzprobleme sowie Regulierungen und lange Verfahrensdauern entgegen. Die sprunghafte Erhöhung der Investitionsausgaben in künftigen Haushaltsplänen durch eine Änderung oder Umgehung der Schuldenbremse dürfte nicht zu entsprechend höheren realen Investitionen führen. Vielmehr ist davon auszugehen, dass wie in den vergangenen Jahren die Preise steigen und überschüssige Mittel von einem ins nächste Jahr verschoben werden. Die Schuldenbremse bietet derzeit genug Spielraum für eine schrittweise Steigerung der Investitionen, die angesichts der Hindernisse und Unsicherheiten angezeigt ist. Die Änderung oder Umgehung der Schuldenbremse ist in der Diskussion um öffentliche Investitionen derzeit fehlplatziert. Vielmehr besteht die Gefahr, die Glaubwürdigkeit der europäischen Fiskalregeln aufs Spiel zu setzen, die für das Funktionieren der Europäischen Währungsunion und für die unabhängige Geldpolitik notwendig sind.
Production of 67Cu by enriched 70Zn targets: first measurements of formation cross sections of 67Cu, 64Cu, 67Ga, 66Ga, 69mZn and 65Zn in interactions of 70Zn with protons above 45 MeV
Authors: Pupillo Gaia , Mou Liliana , Martini Petra , Pasquali Micòl , Boschi Alessandra , Cicoria Gianfranco , Duatti Adriano , Haddad Férid , Esposito Juan
Published: February 2020

Despite its insufficient availability, Copper-67 is currently attracting much attention for its enormous potential for cancer therapy as theranostic radionuclide. This work aims to accurately measure the unexplored cross section 70Zn(p,x)67Cu in the energy range 45–70 MeV and to evaluate its potential advantages in the case of high-intensity proton beams provided by compact cyclotrons. Thin target foils of enriched 70Zn were manufactured by lamination at the INFN-LNL and irradiated at the ARRONAX facility using the stacked-foils method. A radiochemical procedure for the separation of Cu, Ga and Zn contaminants and the isolation of 67Cu from the irradiated material was developed. The efficiency of the chemical processing was determined for each foil by monitoring the activity of selected tracer radionuclides (61Cu, 66Ga and 69mZn) through γ-spectrometry. Experimental data of the 70Zn(p,x)67Cu, 64Cu, 67Ga, 66Ga, 69mZn, 65Zn cross sections were measured for the first time in the energy range 45–70 MeV and compared with the theoretical results obtained by using the TALYS code. The 67Cu production yield by using enriched 70Zn thick targets was compared with the results obtained by using 68Zn targets in the same irradiation conditions.
Association between human health and indoor air pollution in the Gulf Cooperation Council (GCC) countries: a review
Authors: Amoatey Patrick , Omidvarborna Hamid , Baawain Mahad Said , Al-Mamun Abdullah , Bari Aynul , Kindzierski Warren B.
Published: February 2020

Studies on the assessment of indoor air pollutants in terms of concentration and characterization in the Gulf Cooperation Council (GCC) countries have been recently carried out. This review assesses the health effects associated with indoor air pollution exposures in GCC, including other air pollutants (siloxanes, flame retardants, synthetic phenolic antioxidants) which were not explored in a previous study. In addition, the influence of ventilation conditions due to different indoor environments was also investigated. It was revealed that there is a lack of human health assessment studies on most indoor air pollutants in almost all GCC countries, except the United Arab Emirates, Kingdom of Saudi Arabia and Kuwait, where few attempts were made for some specific pollutants. Commonly reported plausible health effects potentially associated with indoor air pollution were related to respiratory symptoms and sick building syndrome (SBS). Many of the current health assessment studies in GCC countries were based on predictions and/or estimates of exposures rather than clinically based observational studies. Measured ventilation levels and indoor air velocities in most buildings failed to meet the American Society of Heating, Refrigerating and Air-conditioning Engineers (ASHRAE) threshold limits of 8 L/s/p and 0.18–0.25 m/s, respectively. Additionally, limited studies have investigated respiratory symptoms and SBS potentially attributable to poor ventilation in the region. It is highly recommended that future indoor air quality (IAQ) studies in GCC should focus more on epidemiologic and intervention studies.
Investigation of MMP-9 rs3918242 and TIMP-2 rs8179090 polymorphisms in renal cell carcinoma tissues
Authors: Çaykara Burcu , Alsaadoni Hani , Pençe Sadrettin , Pençe Halime Hanım , Ötünçtemur Alper
Published: February 2020

Background

The proteolytic activities of matrix metalloproteinases (MMP), cell surface enzymes degrading extracellular matrix, is inhibited by matrix metalloproteinase tissue inhibitors (TIMP). We aim to detect the effects of MMP-9 rs3918242 and TIMP-2 rs8179090 gene variations in renal cell cancer transformation.

Methods

One hundred tumor and 100 adjacent healthy tissues were obtained from the patients with renal cell cancer. Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) was performed and the products carried out in agarose gel electrophoresis were visualized under UV light. Statistical analyses were performed using SPSS 22 and p-values of less than 0.05 were considered as statistically significant.

Results

MMP-9 rs3918242 T allele was higher in tumor tissues (36.5%) than adjacent tissues (17%) and odds ratio was found 2.8 in T allele (p<0.001). Odds ratio values were found 3.325 in the carriers of TT genotype and 3.5 in the carriers of CT genotype compared to the carriers of CC genotype (p<0.01). The polymorphism of TIMP-2 rs8179090 was not found statically significant in tumor and adjacent tissues (p>0.05).

Conclusion

MMP-9 rs3918242 T allele, TT and CT genotypes can be used as biomarkers in determining of renal cell carcinoma.
Effect of one and two sessions of antimicrobial photodynamic therapy on clinical and microbial outcomes of non-surgical management of chronic periodontitis: A clinical study
Authors: Lafzi Ardeshir , Mojahedi Seyed Masoud , Mirakhori Mahdieh , Torshabi Maryam , Kadkhodazadeh Mahdi , Amid Reza , karamshahi mohamadjavad , Arbabi Mohammad , Torabi Hasti
Published: February 2020

Background. Thisstudy aimed to compare the effect of one and two sessions of antimicrobial photodynamic therapy (aPDT) as an adjunct to scaling and root planing (SRP) on clinical and microbial parameters in patients with chronic periodontitis. Methods. This study was conducted on 20 patients. The dental quadrants of patients were randomly assigned to SRP at baseline (group 1), SRP at baseline and one month (group 2), SRP plus aPDT at baseline (group 3) and SRP plus aPDT at baseline and one month (group 4). Probing depth (PD), clinical attachment level (CAL) gain, and bleeding on probing (BoP) were measured at baseline, and one and three months later. F. nucleatum counts were determined by PCR. ANOVA was used for the comparison of these variables between the groups. Results. In all the groups, PD reduction and CAL gain increased significantly at 1- and 3-month intervals compared to baseline (P=0.001). At three months, the difference in PD between groups 1 and 3 was statistically significant (P=0.014). CAL gain between groups 2 and 4 at one month (P=0.016) and three months (P=0.001) wasstatistically significant. Reduction in F. nucleatum counts was not significant between the four study groups (P>0.05). Conclusion. A combination of two sessions of aPDT and SRP could improve CAL gain; however, further long-term studies are necessary in this regard.
Disparidade urbano-rural na utilização de serviços de saúde em município de pequeno porte
Authors: Vieira Ed Wilson Rodrigues , Dutra Izabela Rocha , Cerqueira Lana Jaya , Gazzinelli Andréa
Published: February 2020

Objetivo: analisar a existência de disparidade urbano-rural na utilização de serviços de saúde por pessoas vivendo em um município de pequeno porte. Métodos: estudo epidemiológico transversal com amostra representativa e aleatória de pessoas com 18 anos ou mais de idade na área urbana (n=1.235) e toda a população de um distrito rural (n=190). Utilizou-se o questionário sobre utilização de serviços da Pesquisa Nacional por Amostra de Domicílios. A análise considerou modelos de regressão logística para examinar fatores associados à utilização nos 30 dias anteriores ao estudo. Resultados: a taxa de utilização pelas pessoas da área urbana foi significativamente maior que da área rural (45,0% vs 15,8%). Mulheres e aqueles que reportaram sintomas de doenças no período e hipertensão arterial tiveram mais chances de utilização. Conclusão: pessoas residentes em área rural utilizam menos serviços de saúde quando comparadas àquelas da área urbana quando estão sob a mesma organização municipal de saúde.
First report on the germination requirement of Pterygopleurum neurophyllum seeds
Authors: Kwon Hyuk Joon , Kim Yu-Ri , Kim Soo-Young
Published: February 2020

Pterygopleurum neurophyllum is a class II endangered species and Red list class CR species in Korea. In this study, we considered the effects of cold stratification on embryo development in P. neurophyllum seeds, and analysed the effect of temperature and light conditions,
immersion time in 50% H2SO4 and GA3 concentration on subsequent germination. The embryo of P. neurophyllum seeds showed elongation after four weeks of cold stratification (4°C) and embryo length was significantly increased after eight weeks. Germinated
seeds were observed after 12 weeks of cold stratification. The cold-stratified (12 weeks) seeds showed the highest germination (23.1%) at 20°C. After 30 minutes H2SO4 immersion, germination of cold-stratified seeds was 29.4%. The GA3 concentration study
showed the highest germination for seeds treated with 0.5 g L-1 GA3 (37.2%). The maximum germination across all treatment combinations was 79.8% for seeds given 30 minutes of 50% H2SO4 treatment and 12 weeks of cold stratification and then treated
for 24 hours in 0.5 g L-1 GA3.
GHR gene transcript heterogeneity may explain phenotypic variability in GHR pseudoexon (6Ψ) patients
Authors: Chatterjee Sumana , Cottrell Emily , Rose Stephen J , Mushtaq Talat , Maharaj Avinaash V , Williams Jack , Savage Martin O , Metherell Louise A , Storr Helen L
Published: February 2020

Objectives

The homozygous GH receptor (GHR) pseudoexon (6Ψ) mutation leads to growth hormone insensitivity (GHI) with clinical and biochemical heterogeneity. We investigated whether transcript heterogeneity (6Ψ-GHR to WT-GHR transcript ratio) and/or concurrent defects in other short stature (SS) genes contribute to this.

Methods

6Ψ-GHR and WT-GHR mRNA transcripts of four 6Ψ patients (height SDS −4.2 to −3.1) and one control fibroblast were investigated by RT-PCR. Transcripts were quantified by qRT-PCR and delta delta CT analysis and compared using ANOVA with Bonferroni correction. In eleven 6Ψ patients, 40 genes known to cause GHI/SS were analysed by targeted next generation sequencing.

Results

RT-PCR confirmed 6Ψ-GHR transcript in the 6Ψ patients but not in the control. 6Ψ-GHR transcript levels were comparable in patients 1 and 3 but significantly different among all other patients. The mean 6Ψ:WT transcript ratios ranged from 29–71:1 for patients 1–4 and correlated negatively with height SDS (R = −0.85; P < 0.001). Eight deleterious variants in six genes were detected, but the number of gene hits did not correlate with the degree of SS in individual 6Ψ patients.

Conclusion

Variable amounts of 6Ψ- and WT-GHR transcripts were identified in 6Ψ patients but no 6Ψ transcript was present in the control. Higher 6Ψ:WT-GHR transcript ratio correlated with SS severity and may explain the phenotypic variability. Analysis of known SS genes suggested that phenotypic variation is independent of the genetic background. This is the first report of transcript heterogeneity producing a spectrum of clinical phenotypes in different individuals harbouring an identical homozygous genetic mutation.
Decoupling of Apoptosis from Activation of the ER Stress Response by theDrosophilaMetallopeptidasesuperdeath
Authors: Palu Rebecca A S , Dalton Hans M , Chow Clement Y
Published: February 2020

Genetic diseases display a great deal of variability in patient outcomes, much of which is caused by differences in genetic background. The endoplasmic reticulum (ER) stress response commonly modifies degenerative disease...

Endoplasmic reticulum (ER) stress-induced apoptosis is a primary cause and modifier of degeneration in a number of genetic disorders. Understanding how genetic variation influences the ER stress response and subsequent activation of apoptosis could improve individualized therapies and predictions of outcomes for patients. In this study, we find that the uncharacterized, membrane-bound metallopeptidase CG14516 in Drosophila melanogaster, which we rename as SUPpressor of ER stress-induced DEATH (superdeath), plays a role in modifying ER stress-induced apoptosis. We demonstrate that loss of superdeath reduces apoptosis and degeneration in the Rh1G69D model of ER stress through the JNK signaling cascade. This effect on apoptosis occurs without altering the activation of the unfolded protein response (IRE1 and PERK), suggesting that the beneficial prosurvival effects of this response are intact. Furthermore, we show that superdeath functions epistatically upstream of CDK5—a known JNK-activated proapoptotic factor in this model of ER stress. We demonstrate that superdeath is not only a modifier of this particular model, but affects the general tolerance to ER stress, including ER stress-induced apoptosis. Finally, we present evidence of Superdeath localization to the ER membrane. While similar in sequence to a number of human metallopeptidases found in the plasma membrane and ER membrane, its localization suggests that superdeath is orthologous to ERAP1/2 in humans. Together, this study provides evidence that superdeath is a link between stress in the ER and activation of cytosolic apoptotic pathways.
Філософський аналіз еволюції штучного інтелекту
Authors: Добровольська О. В. , В. І. Штанько
Published: February 2020

Здійснено аналіз сучасного стану розвитку напряму штучного інтелекту з філософської точки зору. Ґрунтуючись на порівняльно-історичному аналізі, з’ясовано, що спричинило кризи в межах цієї сфери, визначено основні обмеження філософського характеру, які не дозволяють створити «сильну» форму штучного інтелекту: його нездатність до саморефлексії, відчуттів, творчості та гнучкої поведінки; обмеження обчислювального підходу; неможливість повної формалізації знання.

Проаналізовано, чим обумовлені успіхи в межах галузі в останнє десятиліття, і чи були подолані раніше виявлені обмеження. З’ясовано, що еволюція напряму ґрунтується на технічних досягненнях останніх років, що допомогло реалізації алгоритмів, які раніше вимагали багатогодинних обчислень. Визначено, що господарювання прагматичного підходу в галузі призвело до роздрібнення досліджень, фрагментації і спрощення уявлення про світ задля вирішення конкретних задач. З’ясовано, що успішне програмне імітування людської діяльності в різних сферах і неможливість вирішення філософських проблем призвели до розвитку тільки «слабкої» форми штучного інтелекту.

Проведене дослідження показало, що через “однобічний” технічний розвиток і відкритість філософських проблем не можна говорити про еволюцію напряму в цілому.
Modality and folk psychology
Authors: Petik Ja. O.
Published: February 2020

The connection of the modern psychology and formal systems remains an important direction of research. This paper is centered on philosophical problems surrounding relations between mental and logic. Main attention is given to philosophy of logic but certain ideas are introduced that can be incorporated into the practical philosophical logic.

The definition and properties of basic modal logic and descending ones which are used in study of mental activity are in view. The defining role of philosophical interpretation of modality for the particular formal system used for research in the field of psychological states of agents is postulated. Different semantics of modal logic are studied. The hypothesis about the connection of research in cognitive psychology (semantics of brain activity) and formal systems connected to research of psychological states is stated.
Вклад ученых и конструкторов ГП «КБ «Южное» им. М. К. Янгеля» в изучение механических колебаний в ракетной технике К 65-летию ГП «КБ «Южное»»
Authors: Е. В. Никифорова  , Г. И. Сокол  , А. С. Лучко
Published: February 2020

В работе обобщены результаты и проведен анализ работ ученых и конструкторов ГП «КБ «Южное» им. М. К. Янгеля» по изучению колебаний и волн в ракетно-космической технике (РКТ). Рассмотрены монографии, диссертации, статьи, в которых исследованы процессы динамики ракетоносителей и космических аппаратов. Достижения коллектива включают в себя важные научно- исследовательские работы из области механических колебаний и волн. Ключевым направлением в развитии РКТ стало не только их изучение, но рождение многих изобретений, которые легли в основу методов гашения вибраций и явлений неустойчивости в работе двигателей. В большинстве своем научно- конструкторские разработки имели грифы «секретно» и «совершенно секретно». Работы ученых, работавших в этих учреждениях, длительное время не были достоянием научной общественности.

В работе представлена история рождения фундаментальных идей применительно к динамике ракетных конструкций. Представлен исторический вклад в развитие идей механических колебаний и волн отдельных ученых – личностей и их научных школ.
Видатний представник дніпропетровської гідробіологічної школи техногенно трансформованих прісноводних екосистем професор Г. Б. Мельников. Сторінки життя та нові документи біографії
Authors: Байдак Л. А.
Published: February 2020

Розглянуто життя та діяльність видатного представника дніпропетровської гідробіологічної школи техногенно трансформованих прісноводних екосистем професора Г. Б. Мельникова. Візначено його вклад у формування вчення про техногенну трансформацію прісноводних екосистем. Підкреслено роль Г. Б. Мельникова у заснуванні нового напряму гідробіологічної науки – космічної гідробіології.
В. Т. Береговий: невідомі матеріали з наукового архіву Полтавського музею авіації і космонавтики до біографії учасника авіаційної справи 30-х рр. ХХ ст
Authors: Пістоленко І. О.
Published: February 2020

Здійснено огляд і аналіз колекції документів із особистого архіву льотчика-космонавта Георгія Берегового, що стосуються діяльності та долі його старшого брата – випускника Всеукраїнської школи льотчиків у Полтаві Віктора Берегового. Відомості з документів, що в копійному вигляді зберігаються в науковому архіві Полтавського музею авіації і космонавтики, ще не були введені до наукового обігу. Вони є важливим доповненням до авіаційної історії Полтавщини, оскільки присвячені братам В. та Г. Береговим, котрі є уродженцями полтавського краю, а також місять цікаві факти з історії авіації 1930-х рр.
The Political and Economic Dimensions of China’s Relations with Latin America ( الابعاد السياسية والاقتصادية لعلاقات الصين مع امريكا اللاتينية )
Authors: Dheyaa Shkara Prof. Nadia
Published: February 2020

This research uses scientific analysis to look at China's relations with Latin American countries, especially its investment in those countries.

There are two objectives behind Chinese investments in South America.

The first is to solidify its position as the second largest economic power in the world after the United States of America. China's position is further ensured by its huge store of raw materials and energy sources that support its accelerating economic needs of energy to keep pace with the steady growth of its economy.

The second objective is to prevent and deter the United States of America from harming the growing Chinese interests in the world by restricting the effects of the American Containment and Pivot strategies, which revealed the determination of the American administration to besiege China, and its growing influence, economically & politically by alliances & treaties, and to besiege China militarily by American bases Japan, South Korea, the Philippines and others of China's neighbors.

Thus, China considered it only fair to retaliate by strengthening its relations with U.S.A. neighbors, especially the Latin American countries who are U.S.A.'s backyard and strategic backers, and who can restrict the American ability to harm China's vital interests.
IRRIGATION SCHEDULE OF LONG-FRUIT CUCUMBERS AND HYDROAMELIORATIVE REQUIREMENTS FOR DRIP IRRIGATION IN PLASTIC GREENHOUSE
Authors: Kireva Rumiana , Gadjev Roumen
Published: February 2020

The deficit of the irrigation water requires irrigation technologies with more efficient water use. For cucumbers, the most suitable is the drip irrigation technology. For establishing of the appropriate irrigation schedule of cucumbers under the soil and climate conditions in the village of Chelopechene, near Sofia city, the researchеs was conducted with drip irrigation technology, adopting varying irrigation schedules and hydraulic regimes - from fully meeting the daily crops water requirements cucumbers to reduced depths with 20% and 40%. It have been established irrigation schedule with adequate pressure flows in the water source, irrigation water productivity and yields of in plastic unheated greenhouses of the Sofia plant.
NISBAH KELAMIN, UKURAN PERTAMA KALI TERTANGKAP DAN CATCH PER-UNIT EFFORT DUA JENIS LOBSTER KIPAS (SCYLLARIDAE) DI PERAIRAN KUPANG DAN SEKITARNYA
Authors: Wiadnyana Ngurah N , Triharyuni Setiya , Prihatiningsih Prihatiningsih
Published: February 2020

Pemanfaatan lobster kipas (Scyllaridae) yang tertangkap di Perairan Kupang terus meningkat, tetapi informasi mengenai kondisi stok dan aspek biologi nya belum banyak diketahui. Tulisan ini mengkaji nisbah kelamin, rata-rata ukuran pertama kali tertangkap dan catch per-unit of effort (CPUE) lobster kipas di perairan Kupang dan sekitarnya. Kedua spesies lobster kipas yang dianalisis merupakan hasil tangkapan sampingan jaring krendet yang dilakukan oleh nelayan setempat. Jenis data yang dianalisis meliputi data penangkapan dan biologi lobster yang dikumpulkan selama periode Oktober 2015 - Desember 2016. Hasil penelitian menunjukkan bahwa terdapat dua jenis lobster kipas hasil tangkapan sampingan di perairan Kupang, yaitu Scyllarides haanii dan Thenus indicus dengan komposisi hasil tangkapan T. indicus lebih banyak dari S. haanii. Rata-rata ukuran panjang pertama kali tertangkap (Lc) untuk lobster T. indicus betina berdasarkan panjang karapas adalah sekitar 93,79 dan 94,18 mm untuk jantan, sedangkan untuk lobster S. haanii betina adalah 101,40 mm dan 104,06 mm untuk jantan. Nisbah kelamin dari kedua jenis lobster ini masih dalam kondisi seimbang. Rata-rata nilai CPUE lobster jenis T. indicus 3,7 kg/trip lebih besar dibandingkan dengan nilai CPUE S. haanii sebesar 0,8 kg/trip. Nilai CPUE dari tiap-tiap lokasi penangkapan tidak berbeda nyata antar lokasi penangkapan.The utilization of slipper lobster (Scyllaridae) caught in around Kupang waters is increased continuously, however a little information on its stock and biological aspect is available. This paper describes sex ratio, length at first capture and the catch per-unit of effort (CPUE) of the slipper lobster population in the Kupang and surrounding waters. Both slpper lobsters analyzed are a by-catch of a gillnet operated by local fishermen. The data analysized included cacth and biology of lobster collected during the period of October 2015 to December 2016. Results show that there were two types of slipper lobster as by-catch in Kupang waters, namely Scyllarides haanii and Thenus indicus with the number of T. indicus higher than S. haanii. The first lengths of captured (Lc) for female T. indicus based on carapac lenght was 93.79 and 94.18 mm for male, while female S. haanii were 101.40 mm (female) and 104.06 mm for male. The sex ratio of both types of lobsters was still in a balanced condition. The average CPUE of T. indicus was 3.7 kg/trip, higher than that CPUE value of S. haanii of only 0.8 kg/trip. The CPUE value was significantly no different between the fishing location.
UPAYA MEMBANGUN KEMBALI DAN PEMULIHAN STOK IKAN PELAGIS KECIL DI LAUT JAWA
Authors: Atmaja Suherman Banon , Nugroho Duto
Published: February 2020

Tujuan utama makalah ini adalah mengevaluasi kondisi  stok ikan pelagis kecil (dengan ikan layang Decapterus spp. sebagai acuan) sebagai pembangkit ekonomi di pantai Utara Jawa perairan laut Jawa WPPNRI 712. Analisis dilakukan sejalan dengan tren penurunan aktivitas penangkapan kapal pukat cincin yang berpangkalan di Pekalongan Jawa Tengah yang telah berlangsung selama hampir dua dekade. Teori klasik tentang penangkapan ikan mengisyaratkan bahwa pemulihan populasi ikan dapat berlangsung cepat jika penangkapan ikan dihentikan pada rentang waktu tertentu.  Analisis menggunakan pendekatan surplus produksi non-ekuilibrium dengan bantuan perangkat aplikasi ASPIC 7 dan Kobe plot digunakan untuk  memetakan perubahan arah status stok ikan pelagis kecil yang berkaitan langsung dengan perilaku perkembangan perikanan pukat cincin di laut Jawa pada kurun waktu 1976 - 2014.  Hasil penelitian menunjukkan bahwa penurunan drastis baik jumlah armada pukat cincin maupun aktivitas penangkapannya akibat rendahnya peluang keberhasilan dan tingginya investasi operasional hampir dua dekade  telah telah memberikan peluang terhadap pemulihan stok secara alamiah menuju tingkat biomassa optimal.  Pergerakan status biomasa dan mortalitas penangkapan ikan pelagis kecil secara tahunan yang ditampilkan melalui penggunaan Kobe plot memberikan indikasi bahwa kondisi stok ikan setelah tahun 2015 mengarah pada status yang cenderung baik. The main objective of this paper is to evaluate the status and trend of small pelagic fish stocks (Decapterus spp.) as a major driver of economics in north coast of Java correspond to a direct reduction of purse seine fishing activities at around two decades. Classical theory of fishing suggests that rapid population recovery occurs when fishing pressures is reduced. These phenomenons were analyzed by applying non-equilibrium surplus production model incorporate covariance of the programs package of Aspic 7.  Simple Kobe plots were also applied to track the annual trend of stock status directly which presumably related to the course of fisheries development.  The results showed that drastic decline of fishing pressures of both number of purse seine fleet and their activity within the last decade provided an opportunity of stock recovery at optimum biomass levels. Applying simple Kobe plots indicates the stock status and trend in 2015 relatively in rebuilding condition
BIOLOGICAL CHARACTERISTICS, POPULATION PARAMETERS, EXPLOITATION STATUS AND SPAWNING POTENTIAL RATIO OF GIANT TIGER PRAWN (PENAEUS MONODON FABRICIUS, 1798) IN SEBATIK WATERS, KALIMANTAN UTARA
Authors: Tirtadanu Tirtadanu , Chodrijah Umi
Published: February 2020

The limited data and the unreported information about the yields of giant tiger prawn  (Penaeus monodon Fabricius, 1798) in Sebatik caused difficulties in estimating potention and stock status of tiger prawn. The study that could be applied for estimating stock status and management strategy for sustainable shrimp fisheries in Sebatik Waters was the  study about biological characteristics, population parameters and spawning  potential ratio. Samples were obtained from the catch of trammel net by fishers  in some landing areas in Tanjung Aru and the biometric data has been collected during April-December 2018. The growth parameters were obtained from the movement of the monthly mode of carapace length that were based on the Von Bertalanffy growth model. Exploitation status was obtained from exploitation rate of E and length based SPR. The results showed that the mean size of shrimps that was captured by trammel net was 46,9±0,14 mmCL for male and 53,4±0,25 mmCL for female. Most of shrimps were caught before they spawn (Lc=51,2 mmCL<Lm=55,8 mmCL) and tiger prawns spawn throughout the year that the peaks occurred in Agustus dan November-December. Female shrimp has larger size (L∞ jantan=66,25 mmCL; L∞ betina=84,5 mmCL) and faster growth rate( K male=1,27 year-1; K female=1,39 year-1) than the male. The natural mortality of male shrimp was the same as the female (M=1,7 tahun-1) while the fishing mortality of male was higher than female (F male=2,13 tahun-1; F female=1,7 tahun-1). Exploitation status of tiger prawn in Sebatik Waters was fully exploited (E=0,5-0,55) and the shrimp stock has not been on growth overfishing yet according to spawning potential ratio of 34%. The shrimps fishing in Sebatik Waters could continue by avoiding the fishing on the nursery ground.