bluuebunny/crossref_metadata_2025 huggingface dataset:
Is underuse of Inhaled Corticosteroids for Asthma in India contributing to 42% of global asthma deaths?
Authors: Salvi Sundeep , Madas Sapna , Ghorpade Deesha , Gadhave Swapnil , Barne Monica
Published: July 2022

Background:

According to the 2019 Global Burden of Disease (GBD) report, India contributes to an estimated 12.9% of global asthma cases (34.3 million) but a disproportionate 42.3% of all global asthma deaths. Also, asthma causes 4.83 million disability-adjusted life years (DALYs) annually in India, four times more than China, which ranks second.

Hypothesis:

We hypothesised that this disproportionate increase in asthma deaths and suffering in India could be due to the under-use of inhaled corticosteroids.

Methods:

Using the estimated number of asthma cases in each state and union territory in India (34.3 million) from the 2019 GBD data, we calculated the expected sales of inhaled corticosteroids (ICS) for asthmatics in India. We assumed that 10% of asthmatics have mild intermitted disease and thus need only 4 units of ICS pMDI per year. The remaining 90% should ideally use 12 units of ICS pMDI or equivalent DPI. We also assumed that 30% of ICS sales in India would be accounted for by the 38 million COPD patients. State-wise actual sales of ICS in India were obtained from IQVIA.

Results:

The total amount of ICS sales in India for asthma obtained from IQVIA was 26.4 million versus the 384.16 million expected sales, which is only 6.8% of the required estimated sales. Moreover, when we correlated state-wise actual sales of ICS in India versus asthma mortality and DALYs (per 100,000 population), we found a significant negative correlation (R = −0.56; P < 0.001 for asthma deaths and R = −0.61; P < 0.001 for asthma DALYs).

Impact and Future Direction:

Policy-makers, health care providers, public health researchers, asthma sufferers and the people at large need to take cognizance of our findings and undertake appropriate measures, such as creating awareness and ensuring availability and regular use of ICS by asthmatics in India.
Chemical changes in root canal dentin of primary teeth after endodontic irrigation
Authors: Purakkal Aparna T. , Peedikayil Faizal C. , Vardhanan Y. Shibu , Chandru T. P. , Kottayi Soni , Melethil Bazanth Yahiya
Published: July 2022

Background:

The current root canal irrigants used in dentistry are either antibacterial or decalcifying agents or their combinations. These agents can alter the chemical structure of dentin as well as change its permeability and solubility characteristics.

Aim:

The aim of this study was to evaluate the mineral content of root canal dentin after irrigating with five different endodontic irrigation solutions Materials and Methods: Sixty primary anterior teeth were selected for the study. Cleaning and shaping was done by step-back technique and divided randomly into six groups (n = 10): BioPure™ MTAD (Group 1), QMix™ 2-in-1 solution (Group 2), 0.9% normal saline (Group 3), coconut water (Group 4), and 5.25% NaOCl (Group 5) and the uninstrumented ten teeth were grouped as Group 6. After irrigation with final irrigants, the teeth were longitudinally divided into two halves. The levels of six elements calcium, phosphorus, oxygen, carbon, arsenic, and fluoride at the coronal and middle third in each specimen was assessed using scanning electron microscopy and energy-dispersive X-ray analysis. Statistical analysis was done by SPSS version 20 using one-way analysis of variance, and the comparison of means was conducted using post hoc Tukey test.

Results:

There was a statistically significant reduction in the calcium level at the coronal third of radicular dentin after irrigating with five different irrigants when compared with the uninstrumented teeth group. The phosphate level at the coronal third of the radicular dentin significantly increased in all the groups except for the saline group. The other elements such as oxygen, fluoride, and arsenic also showed significant differences in the coronal and middle levels after the irrigation.

Conclusion:

The endodontic irrigation by various irrigants changed the mineral levels in primary tooth dentin
Comparative analysis of staining efficacy of Leishman's stain with hematoxylin and eosin stain in the assessment of keratin pearl formation and mitotic figures in different grades of oral squamous cell carcinoma
Authors: Srilatha Tumpuri , Singh Jaya , Raja Dinesh , Jain Trupti , Chandra Akhilesh , Agrawal Rahul
Published: July 2022

Background:

Keratin is an intermediate protein that structures the cytoskeleton of all epithelial cells. Keratin pearl is present in various pathological conditions such as oral squamous cell carcinoma (OSCC). Mitotic figures can be used as a valuable tool in assessing cellular proliferation and act as a prognostic indicator in dysplasia and malignancy of the oral cavity.

Aim:

The aim of this study was to compare the efficacy of Leishman's stain with hematoxylin and eosin (H and E) stain in assessing keratin pearls and mitotic figures.

Materials and Methods:

In total, 30 diagnosed cases of OSCC of three different histological grades were taken. In each case, two sections of 4–5-micron thickness were made and stained with routine H and E stain and Leishman's stain. Staining intensity and specificity results were analyzed statistically using the Chi-square test and P = 0.05 was considered to be statistically significant.

Results:

Both stains can distinguish three different types of OSCC histologically. Leishman's stain demonstrated staining intensity (P = 0.087) and specificity (P = 0.017) comparable to that of routine H and E.

Conclusion:

Leishman's stain distinctly stained the keratin pearl and mitotic figures with a higher intensity. However, H and E showed a higher specificity.
Shifting focus from subtractive to additive technology in digital prosthodontics
Authors: Koppolu Sai Kiran , Manoharan P. S.
Published: July 2022

The advancements in digital technologies have found a widespread application in fabrication of dental restoration with adequate precision and accuracy. Digital methods which are commonly used for fabrication of prosthesis include subtractive methods such as milling and additive methods such as photomelting and photopolymerizing. Digitalization and accuracy are paving the way toward additive technology. The main purpose of this short communication is to mention the advantages, applications, and studies comparing additive and subtractive technology.
Triply mixed coverings of arbitrary base curves: quasimodularity, quantum curves and a mysterious topological recursion
Authors: Hahn Marvin , van Ittersum Jan-Willem , Leid Felix
Published: July 2022

Simple Hurwitz numbers are classical invariants in enumerative geometry counting branched morphisms between Riemann surfaces with fixed ramification data. In recent years, several modifications of this notion for genus

0

base curves have appeared in the literature. Among them are so-called monotone Hurwitz numbers, which are related to the Harish–Chandra–Itzykson–Zuber integral in random matrix theory and strictly monotone Hurwitz numbers which enumerate certain Grothendieck dessins d’enfants. We generalise the notion of Hurwitz numbers to interpolations between simple, monotone and strictly monotone Hurwitz numbers for arbitrary genera and any number of arbitrary but fixed ramification profiles. This yields generalisations of several results known for Hurwitz numbers. When the target surface is of genus one, we show that the generating series of these interpolated Hurwitz numbers are quasimodular forms. In the case that all ramification is simple, we refine this result by writing this series as a sum of quasimodular forms corresponding to tropical covers weighted by Gromov–Witten invariants. Moreover, we derive a quantum curve for monotone and Grothendieck dessins d’enfants Hurwitz numbers for arbitrary genera and one arbitrary but fixed ramification profile. Thus, we obtain spectral curves via the semi-classical limit as input data for the Chekhov–Eynard–Orantin (CEO) topological recursion. Astonishingly, we find that the CEO topological recursion for the genus 1 spectral curve of the strictly monotone Hurwitz numbers computes the monotone Hurwitz numbers in genus 0. Thus, we give a new proof that monotone Hurwitz numbers satisfy CEO topological recursion. This points to an unknown relation between those enumerative invariants. Finally, specializing to target surface

ℙ^1

, we find recursions for monotone and Grothendieck dessins d’enfants double Hurwitz numbers, which enables the computation of the respective Hurwitz numbers for any genera with one arbitrary but fixed ramification profile.
Multiple scaling limits of $\operatorname{U}(N)^2 \times \operatorname{O}(D)$ multi-matrix models
Authors: Benedetti Dario , Carrozza Sylvain , Toriumi Reiko , Valette Guillaume
Published: July 2022

We study the double- and triple-scaling limits of a complex multi-matrix model, with

\mathrm{U}(N)^2\times \mathrm{O}(D)

symmetry. The double-scaling limit amounts to taking simultaneously the large-

N

(matrix size) and large-

D

(number of matrices) limits while keeping the ratio

N/\sqrt{D}=M

fixed. The triple-scaling limit consists in taking the large-

M

limit while tuning the coupling constant

\lambda

to its critical value

\lambda_c

and keeping fixed the product

M(\lambda_c-\lambda)^\alpha

, for some value of

\alpha

that depends on the particular combinatorial restrictions imposed on the model. Our first main result is the complete recursive characterization of the Feynman graphs of arbitrary genus which survive in the double-scaling limit. Next, we classify all the dominant graphs in the triple-scaling limit, which we find to have a plane binary tree structure with decorations. Their critical behavior belongs to the universality class of branched polymers. Lastly, we classify all the dominant graphs in the triple-scaling limit under the restriction to three-edge connected (or two-particle irreducible) graphs. Their critical behavior falls in the universality class of Liouville quantum gravity (or, in other words, the Brownian sphere).
Modelling Insecticide Resistance of Malaria Vector Populations in Tanzania
Authors: Bisanzio Donal , Ally Mohamed , Ali Abdullah S. , Kitojo Chonge , Serbantez Naomi , Kisinza William N. , Magesa Stephen , Reithinger Richard
Published: July 2022

Anopheline mosquito insecticide resistance is a major threat to malaria control efforts and ultimately countries’ ability to eliminate malaria. Using publicly available and published data we conducted spatial analyses to document and model the geo-spatial distribution of Anopheles gambiae s.l. insecticide resistance in Tanzania at national, regional, district and sub-district levels for the 2011 – 2017 period. We document anopheline mosquito resistance to all four major insecticide classes, with overall mosquito mortality declining from 2011 to 2016, and mean reductions of 1.6%, 0.5%, 0.4%, and 9.9% observed for organophosphates, carbamates, organochlorines and pyrethroids, respectively. An insecticide resistance map modeled for 2017 predicted that anopheline vector mortality was still above the 90% susceptibility threshold for all insecticide classes, except for pyrethroids. Using the model’s output we calculated that resistance to organophosphates, carbamates, organochlorines, and pyrethroids is expected to exist in 11.6%, 15.6%, 8.1%, and 19.5% of Tanzania’s territory, respectively, with areas in the Lake Zone and eastern Tanzania particularly affected. The methodology to predictively model available insecticide resistance data can readily be updated annually, allowing policy makers and malaria program management staff to continuously adjust their vector control approaches and plans, and determine where specific insecticides from various classes should be used to maximize intervention effectiveness.
A Survey Assessing Antimicrobial Prescribing at United Nations Relief and Works Agency Primary Health Care Centers in Jordan
Authors: Orubu Ebiowei S. F. , Albeik Shatha , Ching Carly , Hussein Rana , Mousa Ayoub , Horino Masako , Naqa Rabie , Elayyan Mohammad , Saadeh Rawan , Zaman Muhammad H.
Published: July 2022

Antimicrobial resistance (AMR) is a public health emergency. There is insufficient information on AMR in the context of humanitarian settings. An understanding of behavioral and institutional-level factors can strengthen antimicrobial stewardship. This study used a semistructured questionnaire to assess both knowledge, attitudes, and practices (KAP) on antimicrobial use, resistance and stewardship, and options to improving prescribing, among prescribers at the Primary Healthcare facilities of the United Nations’ Relief and Works Agency Jordan field office. Responses to the KAP questions were evaluated using the Capability, Opportunity, Motivation, Behavior (COM-B) framework and Bloom’s cutoffs. For each framework component, Bloom’s cutoffs and interpretations were as follows: ≥ 80%, “good”; 60–79%, “moderate”; and < 60%, “poor.” Fourteen options to improve prescribing were each assessed using 5-point Likert scales from very unhelpful to very helpful, aggregated by helpful and very helpful and ranked as follows: > 90%, best/most acceptable; > 80–90%, acceptable; and 70–80% as maybe acceptable/good. The questionnaire response rate was 59% (37/63) with a completion rate of 92% (34/37). Aggregate scores for real knowledge on AMR was 97%; opportunity to improve prescribing 88%; and motivation 16%—participants did not believe that there was a connection between their prescribing and AMR or that they had a key role in helping control AMR. Good options (74% aggregate score) to improving prescribing were the availability of guidelines and resistance data. There was good knowledge of AMR and good opportunities, but poor motivation for rational prescribing or behavioral change. There is a clinical need for AMR data to promote rational antibiotic prescribing.
Evaluating Saliva Sampling with Reverse Transcription Loop-mediated Isothermal Amplification to Improve Access to SARS-CoV-2 Diagnosis in Low-Resource Settings
Authors: Suwarti Suwarti , Zanjabila Sabighoh , Bonifacius  , Da Costa Yacobus , Bogh Claus , Subekti Decy , Jeny Jeny , Dewi Ayu Madri , Nuraeni Nunung , Rahardjani Mutia , Elyazar Iqbal , Nelwan Erni J. , Shankar Anuraj H , Baird J. Kevin , Hamers Raph L.
Published: July 2022

Standard diagnosis of SARS-CoV-2 by nasopharyngeal swab (NPS) and real-time reverse transcriptase-polymerase chain reaction (PCR) requires a sophisticated laboratory, skilled staff, and expensive reagents that are difficult to establish and maintain in isolated, low-resource settings. In the remote setting of tropical Sumba Island, eastern Indonesia, we evaluated alternative sampling with fresh saliva (FS) and testing with colorimetric loop-medicated isothermal amplification (LAMP). Between August 2020 and May 2021, we enrolled 159 patients with suspected SARS-CoV-2 infection, of whom 75 (47%) had a positive PCR on NPS (median cycle threshold [Ct] value: 27.6, interquartile range: 12.5–37.6). PCR on FS had a sensitivity of 72.5% (50/69, 95% confidence interval [CI]: 60.4–82.5) and a specificity of 85.7% (66/77, 95% CI: 75.9–92.6), and positive (PPV) and negative (NPV) predictive values of 82.0% (95% CI: 0.0–90.6) and 77.6% (95% CI: 67.3–86.0), respectively. LAMP on NPS had a sensitivity of 68.0% (51/75, 95% CI: 56.2–78.3) and a specificity of 70.8% (63/84, 95% CI: 58.9–81.0), with PPV 70.8% (95% CI: 58.9-81.0) and NPV 72.4% (95% CI: 61.8–81.5%). LAMP on FS had a sensitivity of 62.3% (43/69, 95% CI: 49.8–73.7%) and a specificity of 72.7% (56/77, 95% CI: 61.4–82.3%), with PPV 67.2% (95% CI: 54.3–78.4) and NPV 68.3% (95% CI: 57.1–78.1%). LAMP sensitivity was higher for NPS and FS specimens with high viral loads (87.1% and 75.0% for Ct value < 26, respectively). Dried saliva on filter paper was stable for 4 days at room temperature. LAMP on either NPS or FS could offer an accessible alternative for SARS-CoV-2 diagnosis in low-resource settings, with potential for optimizing sample collection and processing, and selection of gene targets.
Recent advances in seaweed seedling production: a review of eucheumatoids and other valuable seaweeds
Authors: Jiksing Calvin , Ongkudon McMarshall M. , Thien Vun Yee , Rodrigues Kenneth Francis , Yong Wilson Thau Lym
Published: July 2022

Modern seaweed farming relies heavily on seedlings from natural beds or vegetative cuttings from previous harvests. However, this farming method has some disadvantages, such as physiological variation in the seed stock and decreased genetic variability, which reduces the growth rate, carrageenan yield, and gel strength of the seaweeds. A new method of seedling production that is sustainable, scalable, and produces a large number of high-quality plantlets is needed to support the seaweed farming industry. Recent use of tissue culture and micropropagation techniques in eucheumatoid seaweed production has yielded promising results in increasing seed supply and growing uniform seedlings in large numbers in a shorter time. Several seaweed species have been successfully cultured and regenerated into new plantlets in laboratories using direct regeneration, callus culture, and protoplast culture. The use of biostimulants and plant growth regulators in culture media increases the seedling quality even further. Seedlings produced by micropropagation grew faster and had better biochemical properties than conventionally cultivated seedlings. Before being transferred to a land-based grow-out system or ocean nets for farming, tissue-cultured seedlings were recommended to undergo an acclimatization process to increase their survival rate. Regular monitoring is needed to prevent disease and pest infestations and grazing by herbivorous fish and turtles during the farming process. The current review discusses recent techniques for producing eucheumatoid and other valuable seaweed farming materials, emphasizing the efficiency of micropropagation and the transition from laboratory culture to cultivation in land-based or open-sea grow-out systems to elucidate optimal conditions for sustainable seaweed production.
Phylogeographic patterns in cryptic Bostrychia tenella species (Rhodomelaceae, Rhodophyta) across the Thai-Malay Peninsula
Authors: Bulan Jakaphan , Maneekat Sinchai , Zuccarello Giuseppe C. , Muangmai Narongrit
Published: July 2022

Genetic diversity and distribution patterns of marine macroalgae are increasingly being documented in Southeast Asia. These studies show that there can be significant levels of genetic diversity and isolation between populations on either side of the Thai-Malay Peninsula. Bostrychia tenellla is a common filamentous red seaweed in the region and the entity is represented by at least two cryptic species. Despite being highly diverse and widespread, genetic variation and population structure of this species complex remains understudied, especially around the Thai-Malay Peninsula. We analyzed genetic diversity and inferred the phylogeographic pattern of specimens identified as B. tenella using the plastid RuBisCo spacer from samples from the Andaman Sea and the Gulf of Thailand. Our genetic analysis confirmed the occurrence of the two cryptic B. tenella species (B and C) along both coasts. Cryptic species B was more common in the area and displayed higher genetic diversity than species C. Historical demographic analyses indicated a stable population for species B, but more recent population expansion for species C. Our analyses also revealed that both cryptic species from the Andaman Sea possessed higher genetic diversity than those of the Gulf of Thailand. We also detected moderate to high levels of gene flow and weak phylogeographic structure of cryptic species B between the two coasts. In contrast, phylogeographic analysis showed genetic differences between populations of both cryptic species within the Andaman Sea. Overall, these results suggest that cryptic B. tenella species around Thai-Malay Peninsula may have undergone different demography histories, and their patterns of genetic diversity and phylogeography were likely caused by geological history and regional sea surface current circulation in the area.
From Poor Law to Community Care
Authors: Means Robin , Smith Randall
Published: July 2022

Based on extensive research on primary sources and interviews, this book explores the changing perceptions of the needs of elderly people. It considers the extent to which they have been a priority for resources and looks at the possibilities of policy that combines respect for elderly people with an avoidance of the exploitation of relatives.
A Case of Fatal Disseminated Ascariasis: Clinico-Diagnostic Dilemma
Authors: Shalini Duggal D
Published: July 2022

Ascaris lumbricoides is the most common soil transmitted helminth in India. Hepatobiliary and Pancreatic Ascariasis (HPA) is relatively an uncommon complication. We present a case of fatal HPA with genitourinary involvement. Morbidity and mortality can be minimized by keeping in mind the importance of basic investigations which can lead to a definite diagnosis in such cases for instituting timely treatment.
Analysis of Clinical Outcomes in Connective Tissue Donor Site Healing With Two Different Suturing Protocols: A Prospective Case Control Study
Authors: Pape Reddy Saravanan Sampoornam
Published: July 2022

Background: Connective tissue harvesting from the hard palate has been practiced since decades and remains the ‘gold standard’ for soft tissue grafts. Very little has been researched on healing patterns of the palatal donor site and the incidence of post-operative complications of donor site.

Aim: The aim of the study was to evaluate the influence of two different suturing methods on the healing outcomes of donor site after Connective Tissue Graft (CTG) harvsting.

Material and Methods: Thirty patients who had undergone CTG harvest for various procedures were analyzed for the assessment of clinical healing outcomes of palatal donor site. A similar technique for the harvest of CTG in both groups was used using Liu’s class Ia incision. The method of closure of the donor site in these patients was divided into two groups; Group A – combination of criss-cross and horizontal mattress sutures and Group B – simple interrupted sutures. The parameters assessed preoperatively were palatal tissue thickness, intraoperative superficial palatal flap thickness and postoperatively the incidence of post-operative complications and donor site healing was assessed using Wachtel’s index (2003) at 7 days, 14 days and 1 month postoperatively.

Results: The incidence of complications was more in Group B in comparison to Group A. The healing outcomes differed significantly between Group A and B at 7 days, 14 days and 1 month postoperatively; however, there was no statistically and clinically significant difference at 03 months post operatively.

Conclusion: The combination of criss-cross with horizontal mattress suture for closure of palatal donor site after harvesting with Liu’s Class Ia incision was found to yield superior patient comfort and lesser post-operative complications during the early healing period.
Odontogenic Optic Neuropathy, Clinic, Treatment Dynamics: A Case Report
Authors: NM Moyseyenko
Published: July 2022

Optic nerve neuropathy due to dental lesions is rare but causes complex persistent functional disorders that are difficult to diagnose. The aim of this case report is to show odontogenic optic neuropathy through treatment tactics and observation of structural dynamics and functional changes of the optic nerve with the help of a clinical case. The consultation of the patient was done as per the Department of Ophthalmology, Ivano-Frankivsk National University, Ukraine. Tests such as computed perimetry, Optically Coherent Tomography (OCT) of the optic nerve, Magnetic Resonance Imaging (MRI) of the brain, Computed Tomography (CT) of the paranasal sinuses and immunological blood tests were performed. The patient gave informed consent to access personal data and use it for scientific purposes. In the case of patient S., the combination of neuritis with lesions of the anterior part of the vascular tract is attributed to the background of multiple caries and prolapse of the teeth of the upper jaw in the sinus. Treatment includes a regimen by a dentist for caries and pulse therapy with corticosteroids. From the result, it was possible to reduce the swelling in the nerve fibers of the right eye by 35% and the left eye by 19%. The average sensitivity threshold in the right eye increased by 79% and in the left eye by 90%. In conclusion, we confirm that odontogenic optic neuropathy is a rare form of optic nerve damage. Two-stage treatment (dental and corticosteroids) reduces the nerve fibers swelling and increases retinal ganglion cells sensitivity.
An Evolutionary Adolescent Idiopathic Scoliosis Etiology Spine-Limbs Links, Inspiration and Laterality as Basic Factors
Authors: Mariani Alessandro
Published: July 2022

Moving on an evolutionary sight, this article individualizes three basic human causative factors in adolescent idiopathic scoliosis developing inspiration, bipedal locomotion and lateralities. The integrative approach considers the neuromechanical coupling in respiration, introducing the concept of pneumofascial competition (section one) as the loop that occurs between inspired air and pleural fasciae and then global myofascia. Affordances (possibilities) and constraints of respiratory system match positions and movements of whole body, where the links between spine and periphery (limbs and head) play a determinant part: these connections, the one that involves the spinal transverse plane, are worked out in section two. Therefore, section two appears a decisive step in trying to solve some questions about human bipedal locomotion and its proficiency, again in a neuromechanical coupling view, with totally original considerations about the role of scapula and about the spine as a treble torsion spring. Finally, it is possible to trace out a new adolescent idiopathic scoliosis etiology (section three), adding a third factor: laterality. What is only human is the hyper stressed lateralization (s) by means of cultural requirements. The motor hyper specialization is another form of energy saving (automatism). Thus, all the article is about the evolutionary principle of costs minimizing. Adolescent idiopathic scoliosis is here seen as an evolutionary mismatch disease between human nature and human culture and every curve can be explained in an integrative way, where causes and effects develop a mutual self-powering cycle.
Optimization of Social Media Based on Information and Communication Technology in Population and Civil Registration Office of Surabaya
Authors: Rachman Rio Febriannur
Published: July 2022

This study describes the implementation of public policies on the use of information and communication technology. This qualitative study applies a virtual ethnographic approach. The analysis is carried out by observing website and media pages at four levels; space, document, object, and experimental. The results of this study indicate that the Population and Civil Registration Office of Surabaya has optimized the official website, Twitter, Instagram, and YouTube. Optimization of social media gives convenience for all citizens from various backgrounds to access public services. This policy reduces the use of paper which means it is environmentally friendly. Utilization of media in the network makes services more transparent and accountable. All processes are neatly documented and monitored.
Rancang Bangun Bel Pintu Tanpa Sentuh Menggunakan Microcontroller dan Sensor Infra Merah Berbasis Internet of Things
Authors: Wijanarko Denny , Hariyanto Agus
Published: July 2022

Tombolpadabelberfungsiuntukmembunyikanbel.Tombolpadabeldapatmenjaditempathidup virus penyakit. Jikatombolbelditekandengantanganyangterkontaminasiviruspenyakit,haltersebutdapatberpotensi menjadi media penyebaran virus penyakit. Salah satu teknologi yang dapat mencegah hal tersebutadalah bel tanpa sentuh atau touchless bell. Pada touchless bell, tombol akan digantikan dengan sensor untukmembunyikan bel. Pada penelitian ini, touchless bell akan menggunakan microcontroller ESP32-CAM, modulkameraOV2640,sensorinframerahE18-D80NK,buzzeraktif,relay,danaplikasiTelegram.Diharapkannantinya sensor dapat menghidupkan bel serta dapat menangkap foto kondisi di depan pintu dan dikirim keaplikasi Telegram. Selain itu alat diharapkan dapat membantu pengguna dalam menangkap serta mengirim fotokondisisekitarbel,menghidupkan dan mematikan buzzer melaluiperintah yangdikirimkan daribotTelegram.
Factors Impact on Perceived Value of Customer in Higher Education
Authors:   Lecture, Department of Business Administration, National Economics University, Hanoi, Vietnam
Published: July 2022

PERCEIVED VALUE'S ROLE IN CONSUMERISM AND HIGHER EDUCATION: The rapid development of all industries and firms in the twenty-first century has increased corporate competitiveness in terms of making customers feel fulfilled and appreciated receive what they have paid for In the service business, perceived value, or customer happiness, is always a prerequisite factor, a critical aspect for the existence and preservation of competitive advantages (Ravald & Gronroos, 1996). To be successful in this field, companies must consider not just the quality of their products and services, but also the feelings and contentment of their customers. Customers will never use a product again if it does not meet their demands or meet their standards, regardless of how "high-quality" the product or service is provided by that company. Overall aspects such as responsiveness, environment, workers, etc., amenities, and so on all affect consumer perception and satisfaction in research on perceived value in various service industries such as internet consumption, supermarkets, hotels, restaurants, and so on. Similarly, the topic of this research study is the customer's perceived value in higher education: influential elements. Universities can use this research to change their behavior, service quality, and service delivery process to better meet and guide customers in Higher Education, such as students, parents, families, society, businesses, and so on, when determining how these factors affect quantitatively and qualitatively the perceived value of customers in Higher Education, such as students, parents, families, society, businesses, and so on.
Macroeconomic Variables and Effect on Stock Prices: Correlation Evidence from Nepal
Authors:   Nepal Open University, Lalitpur, Nepal
Published: July 2022

This paper attempts to study the macroeconomic factors that affect the stock prices in Nepal. It considers the annual data of four macroeconomic variables that affect the NEPSE Index; inflation rate, broad money supply, gross domestic product, and per capita income from 2011-2021 and tries to find out the influence of these variables on the NEPSE index (stock prices). It uses the Pearson correlation matrix to study the relationship between stock prices ad macroeconomic variables. The results obtained from correlation analysis revealed that market performance of stock prices is found to respond positively to broad money supply and gross domestic product and negatively to the inflation rate as expected. Also, the NEPSE index is not affected by the changes in the per capita income of the nation. These findings help to build up economic and financial policies in the nation and stabilize the capital stock market in Nepal.
Competitiveness Analysis of Districts and Cities in Gorontalo Province
Authors:   Faculty of Islamic Economics and Business, IAIN Sultan Amai, Gorontalo, Indonesia
Published: July 2022

Regional competitiveness cannot be separated from innovations developed by a region. The existence of innovation can increase competitiveness whose purpose is the development and welfare of its people. The ability of the Region to increase competitiveness depends on the ability of the Region to find and determine the driving factors of competitiveness and tap economic policies that focus on transforming accelerated economic growth of the region. The purpose of this study is to analyze the competitiveness of the innovation ecosystem of districts and cities in Gorontalo Province. The research method used in this study is a descriptive analysis that can provide an overview and geographical distribution of Gorontalo Province which is then calculated quantitatively. The indicators covered in the innovation ecosystem under study are then tabulated using a standardized score measure which is a statistical method of the Asia Competitiveness Institute (ACI). The results showed that of the six districts and cities in Gorontalo Province studied, three of them had a competitiveness score above average, namely Gorontalo City, Boalemo Regency, and Bone Bolango Regency.
Management of Shweta Pradar(Leucorrhoea)through Ayurveda-A Single Case Study
Authors: Mahmood Sufia , Nematullah Md. , Ghosh Sukumar
Published: July 2022

Shweta Pradari.e. Leucorrhoea, commonly known as vaginal discharge is one of the important major issues experienced in gynecological practice. It is usual to experience some white discharge. Leucorrhoea is a condition in which there is an excessive amount of white discharge from the vaginal area as a result of inflammation or infection of the lower genital tract, which causes discomfort. Physiologically or pathologically, the symptom can affect people of any age. The vulnerable are those with a low socioeconomic status. Most women of all ages have dealt with it, especially when they are of child bearing or reproductive age. As in our country due to poor nutrition, multiple childbirth, low socioeconomic status, poverty, population growth, negligence of proper hygiene, many women are anaemic, malnourished, ill-health may suffer from such infection. It is important to treat Shweta Pradar(leucorrhoea) as soon as possible because it might lead to major complications if not treated. For abnormal white vaginal discharges, theword "Shweta Pradar" has been described in Ayurvedaandit is extensively discussed in Ayurvedictexts. Due to kaphaand Vata Doshadhikya, this symptom appears. However, according to Charak Samhita, Kaphais the primary Doshathat causes leucorrhoea. In this case report, a 24-year-old female patient with Shweta Pradar has complained of white discharge for the past nine months, along with katisula(low back ache), Daurbalya (weakness), Kandu (itching), Durgandha (odour), and occasionally Daha (burning sensation). She was treated by Shamana Chikitsa(palliative treatment) and Yoni Prakshalanafor one month. She got excellent relief in symptoms by above treatment
A Review on Ethnomedicinal Claims of Desmodium Triquetrum(L.) DC.
Authors: A. Manave Ankita , Patel Bhupesh , Pandya Preeti
Published: July 2022

Desmodium triquetrum(L.) DC.is synonym ofTadahagitriquetrum(L.) H.Ohashibelongs to the family Fabaceae.Desmodiumtriquetrum (L.) DC. is traditionally used in common cold, sore throat, hemoptysis due to lung diseases, hepatomegaly, enteritis, traumatic injury, etc. Aim:The aim of this review is to provide comprehensive information on ethnomedicinal claims ofDesmodium triquetrum(L.) DC. from published literatures, books related to ethnobotany and ethnomedicine. Materials and Methods:All the available information on Desmodium triquetrum(L.) DC.was collected via published literatures, books like Medicinal plants of Gujarat, Reviews on Indian medicinal plants, The wealth of India NISCAIR, etc. The obtained information was distributed into part-wise ethnomedicinal claims,region-wise traditional claims, local names in different languages, and therapeutic indications. Result:It has been found to be reported in more than 23 states in India, widely distributed in western parts of India common in Maharashtra, Kerala, Karnataka, Gujarat etc.Its root, leaves, and the whole plant has been recommended in 19 different diseases both externally and internally. The whole plant has maximum application in 12 different diseased conditions, followed by root and leaves in 4 and 3 diseases respectively. Conclusion:Desmodium triquetrum(L.) DC. is widely used for treatment of chronic cough and tuberculosis and also, the leaves have been used as a substitute for tea by hill tribes in upper Assam. As the findings, Desmodiumtriquetrum (L.) DC. need to explore with the help of detailedinvestigation,especially through pharmacological properties.
Akshi Tarpana:An Eye Rejuvenation
Authors: Sushmita  , Anjali
Published: July 2022

Akshiis the most important Gyan Indriya. It is the site of Alochaka Pitta.SushrutaThe Father of Surgery has recommended “Kriyakalpa”for the management of Akshi Roga. The term Kriyakalparefers to the treatment, which can be applied for almost all types of Akshi Roga.Kriyakalpacomprises ofTarpana, Putpaka, Seka, Aschyotana and Anjana. Akshi Tarpana is a procedure to ensure that the healthy status of the eye is maintained in a normal condition as well as diseased states. In this procedure medicated oil or ghee is retained in the eyes for fixed time in a specific formed frame. According to modern pharmacology, drug penetration depends upon permeability of layers. The epithelium & endothelium of cornea is highly permeable for lipid content, while stroma is permeable to only water content. Thus, fat soluble and water-soluble drugs readilypenetrate these layers. In this article there is a review on Akshi TarpanaKarma, their indications, contraindications and possible mode of action is discussed.
A Comprehensive Study of Manain Shavasana
Authors: Saini Kratika , Kumari Priyanka , Thakur Balaji , PratapSingh Bhanu
Published: July 2022

Increase incidence of Manasika Vikaraor mental illness is the main concern in today’s world. Manasikadoshagenerally vitiates the mind and causes different psychological conditions. In Bhagvat Gita lord Krishna says that, our Aatma is our real friend but positive thinking and control over mind is very important otherwise it becomes our enemy and at that time mental disorders occur. There are so many treatments described in ayurvedic and modern practises. As prevention is better than cure its better to practise yoga to reduce stress. several studies on result of standard observe of yogasana have discovered physical and mental welfare. In today’s world, everybody feels stressed from time to time, Stress may be a feeling of being beneath abnormal pressure. This pressure will come back from totally different aspects of your daily life. In currently stress is taken into account a significant causative issue for several diseases. In several analysis it's been found that Stress caused thanks to varied factors that have an effect on vascular system. Several studies have shown that active of Shavasanadecreases the guts rate, improves the compliance of the blood vessels, regulates regular recurrence, and will increase the stroke volume. This article is tried to focus on,how Shavasanaaffect our mind form classical and modern point of view
Fluidoterapia en pediatría: solución salina vs. soluciones balanceadas
Authors: Rodríguez-Portelles Alfredo Carlos , Campos Miño Santiago
Published: July 2022

Introducción: La elección de la solución cristaloide de resucitación en pediatría es uno de los tópicos más controversiales de la práctica pediátrica moderna. La gran variabilidad de criterios y evidencias por parte de la comunidad médica internacional, producen una duda científica razonable que justifica explorar el estado del arte sobre el uso en niños de solución salina versus soluciones balanceadas para resucitación. Método: Revisión bibliográfica en las bases de datos Pubmed, Scielo, EBSCO, Cochrane Library Plus, Scopus, y Medline Plus. Se seleccionaron 51 artículos publicados, fundamentalmente, en los últimos cinco años, en idioma español o inglés, así tambien como se examinaron las recomendaciones de guías internacionales sobre fluidoterapia de resucitación en pediatría. Resultados: Se describe el trasfondo fisiológico y ácido/básico que justifica las indicaciones y efectos adversos de los cristaloides endovenosos. Se identifican las ventajas y usos clínicos de los mismos. Se discuten las evidencias de su uso en diversas entidades como sepsis y shock séptico, cetoacidosis diabética, diarrea y deshidratación, entre otros. Conclusiones: A diferencia de recientes resultados en estudios de adultos, la evidencia en niños ha demostrado que las soluciones balanceadas disminuyen el riesgo de lesión renal aguda y la necesidad de terapia de reemplazo renal. Existen sólidos resultados que respaldan el uso de soluciones balanceadas en la resucitación de la cetoacidosis diabética pediátrica. Se propone utilizar la fluidoterapia de resucitación con cristaloides en pediatría de manera individualizada, en respuesta al sustrato fisiológico de la entidad clínica de cada paciente.
Pneumokokkenvaccinatie en lassers: als de rook om je hoofd is verdwenen
Authors: Van Hooste W.L.C.
Published: July 2022

Pneumococcal vaccination and welders: when the smoke dissipates…

Although pneumococcal disease is a major cause of morbidity and mortality, it is a rare disease in the working population. Since several decades, exposure to metal fumes is known to increase the risk of lobar pneumonia among an important occupational group, namely welders and metal workers. The theory is that metal fume alters the bacterial properties and/or the worker’s ability to withstand infection. The exact mechanisms are, however, still unclear.

Outbreaks of invasive pneumococcal disease (IPD) caused by the siderophilic, gram-positive bacterium Streptococcus pneumoniae have been quite rare. However, several outbreaks have been reported at Finnish, French, Northern Irish, Norwegian, Singaporean and Swedish shipyards since 2015. Shipyard workers might have a higher risk of developing IPD mainly due to specific environmental factors present at shipyards. Preventive measures may include pneumococcal vaccination, improved ventilation, occupational hygiene measures, reinforcement of the proper use of respiratory protective equipment and anti-smoking campaigns.

Therefore, targeted pneumococcal vaccination is recommended and should be offered to welders and potentially others with relevant occupational exposure to metal fumes (inorganic dusts) after the for an employer obligated risk assessment. This has been discussed in for example Norway, Sweden and the United Kingdom, but there is a need for increased international awareness of the occupational risk of severe pneumococcal disease.
Ta’lim sohasidagi korruptsiyaning o‘ziga xos xususiyatlari va turlari
Authors: Sobirova Nozimaxon
Published: July 2022

Korruptsiya ommaviy xarakterga ega va keng tarqalish sohasi bilan ajralib turadigan murakkab ijtimoiy hodisa sifatida ta’lim tizimiga ham kirib keldi. Ishonch bilan ayta olamizki, aynan ta’lim tizimi korruptsiyaga moyil bo‘lgan sohalardan biri bo‘lib, faoliyatining o‘ziga xos xususiyatlariga ko‘ra, unda o‘qituvchilar va o‘quvchilar o‘rtasida va muassasa xodimlari uning ma’muriyati bilan ham vertikal, ham gorizontal munosabatlar mavjudligi sababli ushbu salbiy hodisaga moyil bo‘ladi. Ta’lim sohasidagi korruptsiya umumiy korruptsiya tushunchasining barcha xususiyatlariga ega. Biroq, korruptsiyaga oid huquqbuzarliklarning o‘z vaqtida oldini olish uchun amaliyotda qo‘llanilishi mumkin bo‘lgan tizimli bilimlarni shakllantirish uchun uning bir qator xarakterli xususiyatlarini aniqlash kerak ko‘rinadi. Ta’lim sohasidagi korruptsiyaga bag‘ishlangan ko‘plab ishlarga qaramay, uning xarakterli xususiyatlari, shakllari, turlari masalasi ochiqligicha qolmoqda. Muallif ushbu maqolada ta’lim sohasidagi korrupsiyani bir qancha mezonlarga ko‘ra tasniflashga harakat qilib, ushbu turdagi tadqiqotlarni o‘tkazishning ahamiyatini bayon qilgan.
Nominata
Authors: Acertte Revista
Published: July 2022

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Kajian Potensi Pemanfatan Limbah Tailing PT. Freeport Sebagai Bahan Stabilisasi Tanah Untuk Perkerasan Jalan
Authors: Irianto Irianto , Mabui Didik S. S. , Rochmawati R. , Sila Ardi. A. , Yunianta A. , Rasyid A.
Published: July 2022

Problems that often occur in road infrastructure, especially in the Papua region, are wavy, cracked and subsidence of the land. Damage to buildings in the form of cracks in walls and floors and building subsidence is sometimes caused by poor physicalzand mechanicalzcharacteristicszof thezsoil. Soil stabilization on the subgrade of a construction is a method used to improve the properties of the subgrade. Tailing waste utilization of  PT. Freeport will greatly assist the government's program in overcoming environmental pollution as well as as a soil stabilization material for road construction. The purposezof thiszstudyzwas tozdetermine whetherzthe land in the Musamus University, Merauke area is suitable for stabilization using  tailing PT. Freeport and to determine the optimum value of tailings used as a stabilizing agent to reduce the value of the original soil Plasticity Index. The original soil plasticity index value is 28.96%, the soil plasticity index value at 5% tailings content is 17.2395%, at 10% tailings grade is 10.1402%, at 15% tailings grade is 5.4228%, at 10% tailings grade. 20% tailings by 6.8704%. So that the soil is suitable to be stabilized using tailings and the optimum level of tailings used is at a level of 15%.
Edukasi Pencegahan dan Penanganan Hipertensi Untuk Meningkatkan Kualitas Hidup Pada Lansia
Authors: Nuraisyah Fatma , Kusumo Hafizh Radityo
Published: July 2022

Hipertensi telah menjadi salah satu penyakit tidak menular yang terus meningkat dari tahun ke tahun di dunia. Hampir semua penderita hipertensi berusia lanjut. Pencegahan dan perawatan diri berhubungan dengan kualitas hidup. Penelitian ini bertujuan untuk pendidikan pencegahan dan perawatan diri untuk peningkatan kualitas hidup pada lansia. Metode yang digunakan adalah deskriptif analisis dengan penyebaran leaflet dan pendekatan true eksperimen dengan desain nilai pretest-postest. Hasil menunjukkan bahwa terdapat perbedaan antara nilai pre-test dengan nilai post-test.
Studi Panjang dan Sudut Kemiringan Umpan Ikan Buatan (JIG) Terhadap Perubahan Pola Aliran Fluida
Authors: Kevin Kevin , Qiram Ikhwanul , Rubiono Gatut
Published: July 2022

Umpan merupakan salah satu alat bantu yang berpengaruh pada daya tarik dan rangsangan ikan dalam kegiatan pemancingan ikan. Umpan jig adalah umpan buatan yang dapat memicu perubahan pola aliran arus air yang menjadi daya tarik ikan untuk memangsa jig. Tujuan penelitian ini adalah untuk mendapatkan hasil pengaruh panjang jig terhadap perubahan pola aliran fluida. Metode penelitian menggunakan eksperimen dimana terdapat 3 variasi panjang 5,5; 6,5; dan 7 cm dengan lebar 1 cm dan tebal 1 cm. Sudut posisi jig yaitu 0⁰, 15⁰, 30⁰, 45⁰, 60⁰, dan 90⁰. Fluida yang digunakan adalah air tawar. Jenis aliran dikondisikan laminer dengan menggunakan debit sebesar 76,60 liter per/detik. Gerakan jig dibuat naik turun menggunakan prinsip mekanisme engkol dengan sumber gerak motor listrik. Analisis pola aliran menggunakan data visual yang direkam dengan kamera dan dilakukan pengukuran dimensi menggunakan software Kinovea 08.15. Hasil penelitian menunjukkan bahwa panjang dan sudut posisi jig berpengaruh terhadap perubahan pola aliran yang terjadi. Hasil penelitian juga mengungkap mekanisme perubahan pola aliran yang terjadi.