bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparison study of photonic crystal chip detection method and chemiluminescence detection method for tacrolimus concentration
Authors: Wang Xuning , Niu Xinxin , Shi Bin
Published: June 2024

Background
Tacrolimus is an immunosuppressant commonly used for immunosuppressive therapy after organ transplantation. However, tacrolimus has a narrow therapeutic window, and monitoring its blood concentration is crucial for adjusting treatment plans and preventing side effects. Traditional monitoring methods have complex operating procedures and time-consuming issues, so exploring new methods is necessary. Photon crystal chip detection and chemiluminescence are potential methods for monitoring tacrolimus blood concentration. This study aims to compare the advantages and limitations of these two methods and explore their potential applications in clinical practice. Through this study, scientific evidence can be provided to improve monitoring methods and provide better personalized treatment.
Methods and analysis
This study is a single-center, single-blind, diagnostic trial that compares the potential of photon crystal chip detection and chemiluminescence in monitoring tacrolimus blood concentration and exploring their value in clinical practice. The main objective is to detect the fluorescence intensity of the photon crystal chip. Secondary objectives include comparing the reliability, anti-interference ability, and optimization of experimental conditions of the photon crystal chip and chemiluminescence. The experimental flow chart is shown in Fig. 1. Participants are from the Third Medical Center of the Chinese PLA General Hospital. In order to estimate the sample size, we determined four key elements: effect size, success rate of both methods, significance level, and statistical power or sample size. The required sample size was calculated to be 80 cases using a formula. The t-test will be used to compare the differences between the tacrolimus concentration data obtained from the two detection methods to determine if there is a significant difference in concentration measurement. This study has been approved by the medical ethics committee and it is in accordance with relevant guidelines and regulations. Patients or authorized representatives will receive detailed written information before signing an informed consent form. Before signing the consent form, the attending physician or authorized representative will explain the background, purpose, participation content and process, possible benefits and risks, privacy, and other important information to the patient. Participation is voluntary and patients can withdraw at any time without giving a reason. Legally incompetent individuals will be excluded from the trial.
Discussion
This study compares the advantages and disadvantages of using the photonic crystal chip detection method and the chemiluminescence method to detect the concentration of tacrolimus in blood. The purpose is to explore new detection methods to improve monitoring efficiency and accuracy.
Ethics review approval Research ethics number (KY2022-01).
Ethics review date: January 25, 2022
Low-cost detection, transmission, and central monitoring of patients’ vital signs in rural areas: digitizing the Ethiopian rural healthcare system
Authors: Berihun Molla Melese , Kassaw Ewunate Assaye , Wosene Abel Belay , Wondimagegn Matiwos Tekalign , Gashaw Yishak Adamtew , Limenh Mulusew Yilie
Published: June 2024

Background
monitoring vital signs is essential for identifying patient issues. However, there are deaths that could have been avoided due to insufficient clinical monitoring and diagnosis delay. In Ethiopia, patients in rural areas are facing challenges like limited system interoperability and overcrowded facilities. The objective of this project is to design a cost-effective system for recording, transmitting, and monitoring remotely located patients’ vital signs from the center.
Methods
radio transmitter and receiver, temperature, oxygen saturation and heart rate sensors, Arduino, keypad, alarm/light indicators and GSM module components were collected. Proteus and Arduino software were used to design and simulate the recording, transmitting and receiving modules individually. The individual modules were assembled. The design was implemented by connecting the components on breadboard. Finally, the assembled system was tested for its functionality.
Results
a device that can record and transmit patient’s room number, bed number, vital sign and other important parameters to the central vital sign monitoring location was designed. The designed system was simulated using proteus software. The simulated design was implemented practically using the mentioned components. The result of practical testing showed that the vital signs and other parameters were recorded successfully by the recorder module and displayed at monitoring location. Furthermore, the device was able to send notification to the physician’s mobile phone via means of messages. Therefore, it is possible to monitor the remotely located patient’s vital sign at the central location using cost effective central monitoring system which can be implemented in low resource setting areas like Ethiopia.
Evaluation of treatment for diffuse large B-cell lymphoma using plasma D-dimer levels
Authors: Shao Ruonan , Meng Danchen , Gao Beibei , Zhang Lu , Meng Qingqi , Hou Yanqiu , Long Zhangbiao , Yan Jinsong , Shi Xiaofeng
Published: June 2024

Objective
It has been documented that D-dimer levels have potential utility as a measure of tumor activity in diffuse large B-cell lymphoma (DLBCL), however whether it can be used as a predictive marker of treatment outcome has not been established. This study means to retrospectively evaluate the role of D-dimer in prediction of treatment efficacy in patients with DLBCL.
Materials and methods
151 patients with newly diagnosed DLBCL were enrolled. Blood samples were taken from those patients during the initial visit to our hospital and again after two cycles of chemotherapy to measure D-dimer levels. The link between plasma D-dimer concentrations and patients' clinical characteristics was explored before and after treatment.
Results
Patients showed statistically different plasma D-dimer levels at initial consultation across the four treatment-response groups [ complete response (CR), partial response (PR), stable disease (SD), and progressive disease (PD)]. Those in CR group had significantly lower D-dimer levels at initial consultation than those in PR and PD groups (p < 0.05). After chemotherapy, the PR group had considerably lower D-dimers than the SD and PD groups did (p < 0.05). The D-dimer difference percentage was lower in PR group than that in PD group (p < 0.05).
Conclusion
Patients who respond well to chemotherapy typically exhibit lower D-dimer levels at the initial diagnosis. Those in the SD or PD groups usually experience a greater increase in D-dimer levels following chemotherapy. Consequently, variations in plasma D-dimer levels before and after treatment may offer valuable insights for evaluating the efficacy of chemotherapy treatment.
Vanished Livelihoods’: Reverberations of Civil War in Swat, Pakistan
Authors: Bhatti Haseeb , Lim Steven
Published: June 2024

This article specifically probes, how the Taliban occupation and subsequent civil war caused disaster, destruction and damages—which severely distressed sustainable household livelihoods in Swat region of Pakistan. This case study relies on primary data from a household survey conducted in five out of seven conflict affected sub-districts of Swat. The quantitative methodology consists of a two-step procedure. First, a k-means clustering tool validates the household classification in Swat. The clustering algorithm produces five robust clusters (i.e., k = 5). Second, we find asset base (human, physical, social, natural and financial) constraints in pursuing alternate high return and sustainable livelihood possibilities. This study reveals specific limitations in terms of human and financial capitals in the region. Nevertheless, physical capital’s enhancement and asset values, increase the likelihood of adopting high-income portfolios. Therefore, we highlight priority improvements in wide-ranging infrastructural necessities. We maintain that these factors possess strong potential to enhance household specific asset deficiencies and make household livelihood choices sustainable again. Such sustainability has potential to diminish their chances to sympathise and join militants once more. If not, they may come under their potent influence again—as widely circulated reports in media about violent incidents reveal these days.
Stochastic stem bucking using mixture density neural networks
Authors: Simon Schmiedel
Published: June 2024

Poor bucking decisions made by forest harvesters can have a negative effect on the products that are generated from the logs. Making the right bucking decisions is not an easy task because harvesters must rely on predictions of the stem profile for the part of the stems that is not yet measured. The goal of this project is to improve the bucking decisions made by forest harvesters with a stochastic bucking method. We developed a Long Short-Term Memory (LSTM) neural network that predicted the parameters of a Gaussian distribution conditioned on the known part of the stem, enabling the creation of multiple samples of stem profile predictions for the unknown part of the stem. The bucking decisions could then be optimized using a novel stochastic bucking algorithm which used all the stem profiles generated to choose the logs to generate from the stem. The stochastic bucking algorithm was compared to two benchmark models: A polynomial model that could not condition its predictions on more than one diameter measurement, and a deterministic LSTM neural network. All models were evaluated on stem profiles of four coniferous species prevalent in eastern Canada. In general, the best bucking decisions were taken by the stochastic LSTM models, demonstrating the usefulness of the method. The second-best results were mostly obtained by the deterministic LSTM model and the worst results by the polynomial model, corroborating the usefulness of conditioning the stem curve predictions on multiple measurements.
Evaluation of Epidermal and Dermal Wound Healing of Dexemedetomidine in Rat Model
Authors: Soylu Seçil , Sarıtaş Zülfükar Kadir , Sarıtaş Tuba Berra , Görücü Fatma , Bülbül Aziz , Demirel Hasan Hüseyin , Koç Yusuf
Published: June 2024

Wound healing, which is a complex and systematic process initiated by the body immediately after injury, is affected by many factors that can accelerate or delay this process. In this study, we aimed to evaluate the effects of dexmedetomidine on wound healing in rats. Our randomized controlled experimental study was conducted on a total of 16 male Wistar albino rats, divided into 8 control groups where the wound was covered only with sterile gauze and 8 experimental groups where dexmedetomidine was applied and then covered with sterile gauze and bandage. The wound areas of the rats were measured, histological evaluation and biochemical analysis were performed and, compared between groups. Our results showed that total antioxidant status (TAS) score was higher in the dexmedetomidine group and total oxidant status (TOS) score was higher in the control group. Interleukin-1, interleukin-6, tumor necrosis factor-α, hydroxyproline and epidermal growth factor scores of the groups did not show a statistically significant difference. Left lateral wound measurement of the dexmedetomidine group on the 1st and 3rd days was statistically wider than the left lateral wound measurement of the control group. There was a statistically significant decrease in wound sizes in all groups and on days 1-3-7-9.-12-15.-17.-21. The dexmedetomidine group had more pronounced reepithelialization and more intense collagen deposition compared to the control group. Based on our results, we concluded that dexmedetomidine may have an improving role in the wound healing process but more comprehensive studies are needed to evaluate the effects of dexmedetomidine on wound healing.
Toxoplasma gondii IgG Serointensity and Cognitive Function in Bipolar Disorder
Authors: Rensch Paul , Postolache Teodor T. , Dalkner Nina , Stross Tatjana , Constantine Niel , Dagdag Aline , Wadhawang Abhishek , Mohyudding Farooq , Lowryd Christopher A. , Josephb Joshua , Birner Armin , Fellendorf Frederike T. , Finner Alexander , Lenger Melanie , Maget Alexander , Painold Annamaria , Queissner Robert , Schmiedhofer Franziska , Smolle Stefan , Tmava-Berisha Adelina , Reininghaus Eva
Published: June 2024

Background
Alongside affective episodes, cognitive dysfunction is a core symptom of bipolar disorder. The intracellular parasite Toxoplasma gondii has been positively associated with both a diagnosis of bipolar disorder as well as poorer cognitive performance, across diagnostic boundaries.
Methods
A total of 76 participants with bipolar disorder were tested for Toxoplasma gondii -specific IgG and IgM antibodies and for cognitive performance with a neuropsychological test battery. Cognitive parameters were categorized into three cognitive domains (attention and processing speed, verbal memory, executive function). Statistical analysis of associations between continuous indicators of cognitive status as dependent variables in relationship to Toxoplasma gondii, included multivariate analyses of co-variance for seropositivity, and partial correlations with IgG serointensity in IgG seropositives. All analyses were controlled for age and premorbid IQ.
Results
In seropositives (n = 27), individual parameters in the verbal memory domain showed significant inverse partial correlations with IgG antibody levels. Cognitive functioning did not differ between IgG seropositive and seronegative individuals in any of the cognitive domains (n = 76). IgM positives (n = 7) were too few to be analyzed.
Conclusions
This investigation is the first to show an association between Toxoplasma gondii IgG serointensity and memory function in a well-diagnosed bipolar disorder sample. While further research is necessary, latent Toxoplasma gondii infections could represent a risk factor for functional decline for patients with bipolar disorder and Toxoplasma gondii serointensity in seropositives may emerge as a biomarker for personalized treatment.
Vesicoureteric reflux and urolithiasis in the paediatric population: causality, correlation or no connection at all?
Authors: Berger Christoph , Haid Bernhard , Oswald Josef
Published: June 2024

Purpose
To investigate the potential influence of vesicoureteral reflux (VUR) on stone formation in children by evaluating causality in terms of temporal coincidence, corresponding laterality, presence of UTI and stone composition.
Methods
Retrospective data analysis was conducted on pediatric patients with stones (group 1) and those diagnosed with VUR (group 2). Data comprises demographics, voiding cysto-urethrograms (VCUGs) stone characteristics, and UTI history.
Results
In Group 1 (73 stone patients, mean age 8.8 years), VUR was diagnosed in 26% of VCUGs (8/31), predominantly in children under 3 years. Only in a minority of 6%, VUR may be causally linked to infection-stones (2/31). In Group 2 (1758 VUR patients, mean age 3.6 years), 0.5% were found to have stones (9/1758), with VUR potentially contributing to stone formation in 0.34% of cases. VUR in stone patients was low grade, except one child with neurogenic bladder and bilateral grade 4 VUR.
Conclusion
An association between VUR and stone formation occurs in very young children and appears incidental rather than causal. Metabolic factors play a more significant role for stone formation. Children with stones need not routinely be subjected to a VCUG.
Medical Nutrition Therapy for critically ill patients in Intensive Care Unit: Assessment of nutritional risk and length of stay
Authors: Alimuddin Indrawaty , Taslim Nurpudji Astuti , Syauki Andi Yasmin , Rasyid Haerani , Aminuddin  , Bukhari Agussalim
Published: June 2024

Background and objectives: Critically ill patients are at high risk of malnutrition which is associated with poor outcomes, increased morbidity, mortality and length of hospitalization. The mNUTRIC score is a nutritional screening and assessment tool to evaluate low or high risk of malnutrition in hospitalized patients. This study was conducted to determine the relationship between the provision of medical nutrition therapy and the length of stay of patients Intensive Care Unit.
Methods: This study used a retrospective cohort study design on 250 critical patients hospitalized in the Intensive Care Unit in 2020 and 2021. Energy intake was recorded in the form of trophic energy and full energy in patient groups with low and high risk mNUTRIC scores and length of stay, then analyzed the relationship between energy and length of stay in the Intensive Care Unit.
Results: After analyzing patients with low risk of malnutrition, the results showed that energy intake < 600 calories had a length of stay in the ICU with a mean ± SD of 4.76 ± 2.47 days, while energy ≥ 600 calories in patients with a length of stay of 9.65 ± 6.79 days had significant results with a p value = 0.000. Similarly, in high risk malnutrition, the provision of energy intake < 600 calories and ≥ 600 calories, has significant results with a mean ± SD length of stay of 5.00 ± 3.14 days and 11.33 ± 7.81 days, respectively. It can be said that low risk malnutrition patients, both given energy intake < 600 calories and ≥ 600 calories, have a shorter length of stay in the ICU than high risk patients.
Conclusion: Medical nutrition therapy provided as trophic energy and full energy had an association with the length of hospitalization of critically ill patients, where the length of hospitalization was shorter in subjects with low risk compared to high risk.
Impact of Fiber-Containing Enteral Nutrition on Microbial Community Dynamics in Critically Ill Trauma Patients: A Pilot-Randomized Trial
Authors: Serbanescu Mara A. , Wright Mary C. , Arnold Jason , White James R. , Wischmeyer Paul E.
Published: June 2024

Background
Gut microbial dysbiosis in the intensive care unit (ICU) is common, and certain changes, such as expansion of Enterobacteriaceae and other microbes with high pathogenic potential (pathobionts), are associated with increased risk of infection and death. Enteral nutrition (EN) with prebiotic short-chain fructooligosaccharides (scFOS-EN) promotes growth of commensal microbes like Bifidobacterium and certain Firmicutes in non-critically ill patients, and thus may potentially mitigate pathobiont expansion in the ICU. Though widely available, the impact of scFOS-EN on the microbial landscape when initiated in the setting of ICU-associated dysbiosis is still unknown. To address this gap, we conducted a pilot randomized controlled trial (RCT) in critically ill trauma patients to assess effects of scFOS-EN versus a fiber-free formula (NF-EN) on microbial dynamics and ecological interactions.
Methods
In this double-blinded RCT at a level one trauma center, mechanically-ventilated ICU patients with severe trauma (excluding gastrointestinal involvement) were randomized to receive scFOS-EN or NF-EN for 10 days. Stool and oral samples were collected sequentially, and microbial communities were analyzed using 16S ribosomal RNA amplicon sequencing. Linear mixed models were used to assess longitudinal microbiota responses, and network approaches were applied to evaluate gut microbial interactions.
Results
A total of 57 stool and 88 oral samples were included from 7 NF-EN patients and 10 scFOS-EN patients. All patients received broad-spectrum antibiotics and derangements in gut microbiota were present at time of formula initiation. Compared to NF-EN, scFOS-EN was associated with an accelerated loss of Bifidobacterium (-0.6% relative abundance/day, p = .026), and Firmicutes (3.5% /day, p < .001), and expansion of numerous Bacteroidaceae. Further, only scFOS-EN patients demonstrated an expansion in pathobiont Enterobacteriaceae (0.3%/day, p = .003). Network analyses revealed that a unique alliance between co-occurring Enterobacteriaceae and Bacteroidaceae and increased competition may underly changes in the microbiota to scFOS-EN.
Conclusion
Our study suggests administration of scFOS-EN in severe dysbiosis may further deplete beneficial microbes (e.g., Bifidobacterium and Ruminococcaceae) while supporting more resilient colonizers such as Bacteroidaceae, potentially providing a context-dependent advantage to Enterobacteriaceae – pathobionts associated with harm in the ICU. Our findings underscore the importance of investigating ecological interactions in critically ill patients to inform the use of microbiota-targeted therapies.
Trial registration:
The trial was registered (ClinicalTrials.gov, NCT03153397) and approved by Duke Health Institutional Review Board (IRB Pro00081414).
Design of a multiplexed virtual classroom
Authors: Chávez Elizabeth Fonseca , Ruiz-Flores Leticia , Guerrero Nikté Norma Ocampo
Published: June 2024

The purpose of this research is to design a multiplexed virtual classroom model (a technique for combining two or more contents or activities so that a single teacher can help students learn a topic) and to address the issue of classroom management, where the teacher has many activities and little planning time. To determine which contents will be multiplexed, an analysis of learning strategies was conducted, and the strategy was named with the acronym POSTTIE. Consequently, the design of the multiplexed virtual classroom model is presented as a living, cyclical, feedback system that can be implemented by a single teacher or several teachers in different stages of planning, execution, and evaluation, using at least three strategies. To begin, we analyzed which learning strategies were reported by sixth-semester engineering students from a public university to use during their study time. The learning strategies were identified through a questionnaire with an open-ended question, where students were asked to classify their 10 responses. In another section, they listed only one word from those 10 responses to use the first method of natural semantic networks. The results obtained from the questionnaire were then reaffirmed through factor analysis as the second method. Subsequently, a comparison of the results of the applied analysis methods was conducted. Finally, eight learning strategies were named that coincided with both methods and served to validate the results. A quantitative factor analysis was conducted. The exploratory part of the method involved 111 participants; their responses were analyzed using Method 1 and ATLAS.ti© software. The confirmatory part involved 142 participants, and their responses were analyzed using Method 2 with dimension reduction via SPSS and the R language, with a confidence level of 70% and an error < 1.12%.
Exploring the Role of Dietary Fiber in Modulating Treatment Outcomes for Cancer Patients: A Topic Modeling Approach
Authors: Moomin Aliu , Sidik Abubakar Ibn , Sidique Gawusu , Tizumah Marizuk Waris , Adam Maridia Kunateh
Published: June 2024

The effects of both soluble and insoluble fibers on cancer progression, treatment efficacy, and patient outcomes have been explored. This study utilizedadvanced topic modeling techniques to analyze a wide range of academic literature on the role of dietary fibers in cancer treatment. It highlights the significant preventive and therapeutic benefits of dietary fibers, especially their influence on gastrointestinal health, immune system modulation, and inflammation reduction.
The study employed topic modeling approach to provide insights into the interactions of dietary fibers at the molecular and cellular levels, affecting cancerous tissues and patient metabolism associated with cancer treatment. This study highlights gaps in the current literature, such as insufficient details on the underlying mechanisms and the variable impacts of different fiber types on specific cancer treatments. It also identified gaps in diet and cancer research by elaborating on how dietary fibers interact with cancer treatments and assessing their potential to enhance treatment effectiveness and improve patient health. Key findings indicate that dietary fibers significantly reduce the risk of developing gastrointestinal cancers and boost the efficacy of cancer therapies by impacting cellular activities and genetic expression related to cancer. These findings suggest substantial benefits of incorporating dietary fibers into cancer treatment regimens, potentially improving patient recovery and survival. Future research should focus on experimental studies to verify these mechanisms and clinical trials to develop dietary guidelines for cancer patients.
Adsorptive removal of Cd (II) ions from wastewater using biosorbent of Tectona grandis leaves: kinetic, equilibrium and thermodynamic studies
Authors: negi Ankita
Published: June 2024

Heavy metal contaminants are naturally carcinogenic, poisonous, and persistent. In the elimination of harmful heavy metals from polluted water, developing a novel revolutionary biosorbent with high efficiency and low cost from native biomaterial is a difficult task. The utilization of Tectona grandis (teak) leaves to make a possible biosorbent (TGLB) for extracting Cd (II) ions from contaminated wastewater solutions was investigated. To validate the sorption capacity of TGLB, the characteristics of the biosorbent were studied using Scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), point of zero charge (pHPZC), and Brunauer-Emmett-Teller (BET) textural analysis. pH, time, biosorbent dose, temperature, and metal ion concentration were all altered in the batch studies. 93.2% maximal elimination at ideal pH 5 was achieved for a 5 g biosorbent dose, a working solution with a purity of 10 mg/L after a 45 min contact duration. In order to validate the research, the experimental data were also subjected to single-factor analysis (One-way ANOVA) and t-test. The Langmuir sorption model (R2 > 0.999) and pseudo-second-order kinetic model (R2 > 0.998) were the best matches for experimental sorption outcomes. The desorption studies implied that TGLB can be utilized efficiently for three consecutive cycles. A study of the utmost adsorption capabilities of numerous untreated biomaterial-based residues revealed that Tectona grandis leaves biosorbent (TGLB) is an effective, cheap, ecologically and economically friendly biosorbent for application in the elimination of the heavy metals from contaminated aqueous solutions.
Machine Learning Method to estimate parameters of the GPD distribution: Applied to Lobo flows and Yzeron water levels
Authors: Cyrille Okou Gueï , Kolé Keita
Published: June 2024

The Peaks Over Threshold (POT) is an extreme value theory method, used in the management of natural disasters such as floods, economic and financial crisis. These disasters have considerable impacts on the environment and justify the extreme data analysis using the POT. The results showed that, under certain conditions, the excesses distribution can be approximated by a Generalized Pareto Distribution (GPD). One of the major difficulties of POT lies in the GPD distribution parameters estimation, particularly the selection of the optimal threshold.
In this paper, we propose a machine learning method to estimate the GPD distribution parameters. In the First step, we identify the candidate thresholds using the mrlplot graphic and determine the admissible thresholds by the cross-validation method. The admissible thresholds are those which minimize the squared error between the estimated and empirical quantilites of the training and test samples. The shape and scale parameters of the GPD distribution are estimated by the Modified Newton-Raphson numerical method by setting each candidate threshold of the training sample. This numerical method uses a penalized log likelihood function. In the second step, we select the optimal threshold among the admissible thresholds using the Kolmogorov- Smirnov goodness-of-fit test. The optimal threshold is the one which gives the best adequation based on the pvalue and the Kolmogorow statistic. The numerical results for sample sizes (100, 200, 500, 1000, 2000, 5000) showed the reduction in estimation bias of our method for large sample sizes. This technique is illustrated in a case study of Lobo flows and Yzeron water levels, a water resource of great importance in Cˆote d’Ivoire et France.
Concurrent Acute Myocardial Infarction and Acute Ischemic Stroke in a Diabetic Patient Undergoing Chemotherapy for Non-Hodgkin Lymphoma:Should I administer thrombolytic therapy? A Case Report
Authors: Shayo Sigfrid Casmir , Khanbai Khuzeima , Gandye Yona , Kiroga Nakigunda , Waane Tatizo , Kisenge Peter
Published: June 2024

Background
Concurrent ST-elevation myocardial infarction (STEMI) and acute ischemic stroke (AIS) are extremely rare, and their management remains perplexing due to the absence of high-quality evidence and limited resources. For the first time, we report a rare, preventable and suboptimallymanaged case of concurrent AIS and STEMI in a patient with non-Hodgkin lymphoma (NHL) who received cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP) chemotherapy.
Case Presentation
A postmenopausal woman of African origin with a background history of type 2 diabetes mellitus presented to the Jakaya Kikwete Cardiac Institute with sudden onset of left-sided weakness and typical ischemic chest pain for 3 days. The patient was recently diagnosed with NHL and started CHOP chemotherapy 3 weeks prior. Physical examination revealed left-sided hemiplegia. Emergency brain computed tomography (CT) and 12-lead echocardiography (ECG) revealed AIS and STEMI, respectively. A diagnosis of concurrent AIS and STEMI was reached, and the patient was loaded with dual antiplatelets and heparin and rushed for emergency coronary angiography (GAG) and percutaneous coronary intervention (PCI). CAG revealed massive thrombotic occlusion of the mid-segment of the left anterior descending coronary artery (mLAD) and proximal segment of the right coronary artery. Revascularization was achieved in both vessels with a resultant TIMI flow grade of 3. The post-PCI period was marked bysignificant improvement inchest pain and resolution of ST-elevation, as revealed by 12-lead ECG. However, the patient remained hemiplegic.
Conclusion
We have described a rare case of concurrent AIS and STEMI in a postmenopausal woman who had a significant risk of thromboembolism. The patient had uncontrolled type 2 diabetes and received CHOP chemotherapy for NHL, which was diagnosed 3 weeks prior. This case underscores the need for thromboembolic prophylaxis for selected cancer patients receiving chemotherapy. The need to individualize management is also emphasized,as both PCI and thrombolysis carry therisk of serious repercussions. In our patient, if thrombolysis was attempted it would have caused myocardial ruptureand immediate death. The patient would have benefited from endovascular mechanical embolectomy for AIS;however, this practice is lacking at our institution. This calls for the establishment and strengthening of neurointerventional practices in our tertiary healthcare facilities.
Decommunisation of place names in the city of Sumy (2015-2016): how it happened
Authors: Artiukh Vyacheslav
Published: June 2024

The article examines the process of changing the place names of Sumy in 2015–2016 on the basis of decommunisation legislation. It is noted that as early as 1992, after Ukraine gained independence, Sumy considered renaming some place names associated with communist symbols, but these attempts were limited to renaming only a few objects, such as Lenin Street and Square, as well as Karl Marx Avenue.
After the Orange Revolution in 2005, a larger-scale project to decommunise the city's toponymy emerged, but due to Communist opposition, these plans remained at the level of proposals.
A real breakthrough in the decommunisation of place names occurred after the adoption of decommunisation laws. In July 2015, the mayor of Sumy formed a working group on place names, which included various community representatives. The working group determined that street names should reflect the city's historical and cultural ties, as well as reflect national identity. Its work lasted about three months, and as a result, 123 place names were proposed for renaming.
This process had its difficulties. For example, it was important to preserve the national orientation of place names. Although most of the group's proposals were taken into account, not all of them were. There was also a confrontation with opposition forces that tried to stop the decommunisation process. As a result, on 19 February 2016, the mayor of Sumy, Oleksandr Lysenko, signed an order to decommunise 85 place names.
As a result, by 19 May 2016, 98 place names were renamed in Sumy, mostly reflecting the city's historical and cultural ties, as well as Ukrainian national identity.
Physicochemical Properties of Cattail (Typha) Bioproducts as Substitutes for Commercial Horticultural Growing Media
Authors: Boutin Kyle D. , Otte Marinus L.
Published: June 2024

Peat moss is a primary component of horticultural potting mixes, but its extraction is destructive to boreal bogs and results in considerable greenhouse gas emissions. In this study, we conduct a preliminary investigation into whether a suitable alternative could be produced from Typha domingensis. Cattail harvest offers a means to recycle nutrients from eutrophic wetlands but rarely occurs due to a paucity of economically viable uses. This study investigates Typha-derived bioproducts that could serve as peat substitutes, thus replacing a product that degrades wetlands with one that benefits them. Horticulturally relevant physical characteristics (water holding capacity, dry bulk density, and particle size distribution) and chemical characteristics (nitrogen [N] immobilization, pH, and conductivity) were compared for 3 Typha bioproducts (shredded Typha, Typha compost, and Typha biochar), a blend consisting of equal parts of these bioproducts, and 4 commercially sourced conventional media (peat moss, coco coir, biochar, and compost). For all horticulturally relevant characteristics mentioned, our results for the conventional media were similar to those of previous studies on potting media properties. Typha products showed similar physical characteristics to the commercial media, but chemical characteristics were different and might pose challenges. Nitrogen Drawdown Index (NDI) results showed that shredded Typha immobilized N, making this product less suitable for horticulture. Conductivities exceeding the suggested upper limit for growing media (3.5 dS/m) proved to be the main issue for composted Typha (4.6 dS/m) and Typha biochar (29.1 dS/M), but these defects may be corrected through rinsing and, for Typha biochar, a reduction in pyrolysis temperature. Ultimately, results of this study suggest that, with some refinement in processing to improve chemical characteristics, Typha biochar and Typha compost may have a valuable place in potting mixes. If so, this value-added Typha product would provide a financial incentive to harvest problematic stands of Typha and therefore their constituent nutrients from eutrophic wetlands, helping to mitigate the causes of harmful algal blooms and providing an environmentally friendly alternative to the widespread, destructive practice of mining sphagnum peat moss.
PowerPoint
Authors: Proctor Len
Published: June 2024

Capturing the interest of viewers is a first priority item among teachers and other professionals who use media in their presentations. PowerPoint, one of the growing number of PC slide programs becoming available, is one more tool that can be used to achieve this goal. While this program was not intended to replace a graphic artist, it does give the ordinary presenter the ability to create professional looking slides. And, as a fringe benefit, control over the content, sequence and production time has been returned to the user.
SOIL PROPERTIES AND AGRONOMIC EVALUATION OF TOMATO LINES (SOLANUM LYCOPERSICUM L.) IN THE NORTHWEST REGION OF GABON
Authors:   Institut de Recherche Agronomique et Forestiere (IRAF), Centre Nationale de la Recherche Scientifique et Technologique (CENAREST), BP: 2246, Libreville, Gabon., Ndiade Bourobou Dyana , Gnacadja Claude ,   Institut de Recherche Agronomique et Forestiere (IRAF), Centre Nationale de la Recherche Scientifique et Technologique (CENAREST), BP: 2246, Libreville, Gabon., Biroungou Chamforth ,   Institut National SuperieurdAgronomie et de Biotechnologies (INSAB), Masuku University of Science and Technology (USTM), BP: 941, Franceville, Gabon., Nzengue Ephrem ,   Institut de Recherche enEcologie Tropical (IRET), Centre Nationale de la Recherche Scientifique et Technologique (CENAREST), Libreville, Gabon., Mouketou Armel ,   Institut National SuperieurdAgronomie et de Biotechnologies (INSAB), Masuku University of Science and Technology (USTM), BP: 941, Franceville, Gabon., Daudet Medza Mve Samson ,   Institut National SuperieurdAgronomie et de Biotechnologies (INSAB), Masuku University of Science and Technology (USTM), BP: 941, Franceville, Gabon., Francois Mavoungou Jacques ,   Institut de Recherche Agronomique et Forestiere (IRAF), Centre Nationale de la Recherche Scientifique et Technologique (CENAREST), BP: 2246, Libreville, Gabon.,   Institut de Recherche enEcologie Tropical (IRET), Centre Nationale de la Recherche Scientifique et Technologique (CENAREST), Libreville, Gabon.
Published: June 2024

The availability of tomato seeds adapted to local production conditions remains one of the major constraints for a sustainable tomato industry in Gabon. An agro-morphological characterization of ten tomato lines enabled us to assess their potential on the soil of the north-western region of Gabon. At this end, the properties of the soil were analyzed on the one hand, then, agronomic parameters of the tomato lineswere assessed on the other. Univariate and multivariate analyses of agronomic data were carried out using R software. Granulometric analysis revealed that the soil had a silty-sandy structure (29% coarse silt, 28.71% coarse sand). The mineralogical composition shows an assimilable phosphorus content of 15.51ppm and concentrations (in meq/100g) of potassium, calcium, sodium and magnesium of 0.41, 0.99, 0.32 and 0.60 respectively. For agronomic results, flowering time ranged from 26 to 36 DAS and first harvests from 70 to 84 DAS. Line L1 was the earliest and L9 the latest. For the yield, lines L4 (26.7 t/ha) and L8 (20.5 t/ha) were the most productive. The fruits with the best sizes were those of lines L2 (87.7 g) and L4 (86.6 g). Lines L1, L4, L5 and L8 were the firmest. The various diseases observed were downy mildew, spoon yellows and apical necrosis, with a moderate severity index (23,08 %) for all lines. These results show the agronomic performance of certain tomato lines on the sandy-loam soils of Gabon and for varietal improvement programs to increase tomatoes productivity in Gabon.
WAKAF BERTEMPOH (MUAQQAT) SATU CADANGAN PENGIKTIRAFAN, PENGUKURAN DAN PENDEDAHAN DALAM PENYATA KEWANGAN
Authors:   Faculty of Economic and Management, UniversitiKebangsaan Malaysia., Athirah Binti Badlihisham Nur , Fairuz Bin Md Salleh Mohd ,   Faculty of Economic and Management, UniversitiKebangsaan Malaysia.
Published: June 2024

Waqf is one of the important instruments in Muslims economic development. Through waqf, long-term assets that generate income flows can be created and preserved. These assets clearly assist in the generation and creation of wealth. Waqf has the potential to play a significant role in poverty eradication by focusing its benefits on the poor. Most Malaysian states, as indicated in the State Administration of Islamic Law Enactment and the State Waqf Enactment, impose only on perpetuity property based on the Shafiiy school of law. However, there are certain states allowed the implementation of temporary waqf such as Johor, Terengganu, Federal Territory of Kuala Lumpur, and Sarawak. Thus, the purpose of this article is to investigate the barriers to the implementation of temperory waqf in Malaysia, as well as the financial recording. This paper also provides recommendations in the recognition, measurement and disclosure for wakafmuaqqat in the financial statements. This paper has conducted inductive and deductive methods. In this qualitative research, data has been collected by using library research, observations, and interview with some respondents related to wakaf such as Deputy Executive of State Waqf in Selangor and Waqf Manager in Yayasan Canselor University Kebangsaan Malaysia. The result of this paper shows that there are problems in terms of legislation obstacles, lack of expert manpower in managing waqf, and problem of Baitulmals administration that is inefficient and unsystematic. This paper also gives some recommendations in the recognition, measurement and disclosure for temperory waqf in the financial statements.
EFFECTIVENESS OF IMPLEMENTATION OF BLENDED LEARNING AND FLIPPED CLASSROOM METHODS IN HIGHER EDUCATION INSTITUTIONS
Authors:   Department of Innovative Education Tashkent State University of Economics., Mehribonu Kayumova
Published: June 2024

This article is devoted to studying the effectiveness of introducing Blended Learning and Flipped Classroom methods to provide new approaches to learning processes in higher education institutions. Throughout the article, an understanding of these methods, how they are implemented in practice, the importance of using them to improve student learning and morale, and the results obtained from them are compared.
INTELLECTUAL PROPERTY RIGHTS: A BIRDS VIEW AND ITS IMPLICATIONS IN INTELLECTUAL PROPERTY
Authors:   Vidyavardhaka Law College Shesdari Iyer Road, Mysuru-570001., B.R Guruprasad , Alam Aftab ,   Faculties of Vidyavardhaka Law College, Mysuru., N.J Kumara ,   Faculties of Vidyavardhaka Law College, Mysuru., Shivakumara H.S. ,   Faculties of Vidyavardhaka Law College, Mysuru.
Published: June 2024

Intellectual property (IP) is a unique set of ideas and creativity developed in the brain of individuals. It is the assets of individuals and nations which has given exclusive rights to inventors or creators in form of intellectual property rights (IPR). These rights are designated by statutes in order to enable them to implemented for public purpose and maintain the reputation of inventor and his investment on invention. There are different forms of IPR that satisfy the criteria of novelty, non-obviousness and utility. Lack of knowledge on intellectual property rights may cause the damage to economic and social development of nation. The present review highlights various forms of IPR and their role, along with related Indian context. Further, the statutes of IPR related activity have been discussed in brief under a single umbrella.
THE KAMTAPUR MOVEMENT AND THE CALL FOR A DIVIDED STATE IN NORTH BENGAL
Authors:   Assistant Professor Department of Political Science Government General Degree College, Keshiary., Das Kaushik
Published: June 2024

The Kamtapur movement is a socio-political movement that originated in the northern part of West Bengal, India, and it has significant historical, cultural, and political dimensions. This demand is embedded in a distinct cultural and historical identity, tracing back to the ancient kingdom of Kamata. The movement, rooted in ethnic identity and historical grievances, reflects the aspirations of the Rajbongshi community, predominantly inhabiting this region. The demand for a separate state or autonomous region, termed Kamtapur, arises from perceived injustices, including economic disparity, cultural marginalization, and political underrepresentation. Furthermore, the Kamtapur movement intersects with broader issues of identity politics and regional autonomy within Indias federal structure. The Rajbongshi communitys quest for recognition and empowerment within the framework of Indian democracy amplifies the movements significance. Over the years, the movement has witnessed various forms of agitation, including peaceful protests, political lobbying, and, at times, violent clashes. This study covers the historical background of the Kamtapur movement and the various factors that led to the movements demand in North Bengal. It also looks at the dynamics shaping the movement today, such as political mobilization, cultural resurgence, and socioeconomic difficulties. Additionally, it examines the role of various stakeholders, such as political parties, and the state government, in either fuelling or addressing the movements grievances. Our analysis shows that the Kamatapur movement is currently revolving around three main issues i.e. more militant political-cultural demands expressed through violence, moderate political demands for autonomy, and cultural demands for recognition. The movement has received some attention from regional political parties recently, especially during election seasons, as they try to win over the Kamtapuri community. However, neither the Indian government nor the state authorities have accepted their demand for a separate state.
TO ASSESS KNOWLEDGE ATTITUDE AND PRACTICE REGARDING ANAPHYLAXIS AMONG DENTAL STUDENTS IN TERTIARY CARE TEACHING HOSPITAL KHAMMAM
Authors:   Student, Department of Public Health Dentistry, Mamata Dental College, Khammam, India., Lekhana Sri R. , Pratap K.V.N.R. ,   Professor and HOD, Department of Public Health Dentistry, Mamata Dental College, Khammam, India., Madhavipadma T. ,   Professor, Department of Public Health Dentistry, Mamata Dental College, Khammam, India., Sivakalyan V. ,   Reader, Department of Public Health Dentistry, Mamata Dental College, Khammam, India., Srujankumar V. ,   Senior Lecturer, Department of Public Health dentistry, Mamata Dental College, Khammam, India.
Published: June 2024

Background: The term anaphylaxis which was first used in the late 1800s by French scientist Charles Richet, describes a severe allergic reaction that can be fatal .It develops when an allergen a foreign substance causes the immune system to overreact setting off a series of physiological reactions across the body . understanding the knowledge attitude and practice regarding anaphylaxis is important for dental students as they may come across anaphylactic emergencies in their clinical set up. Aim: To assess knowledge attitude and practice regarding anaphylaxis among dental students in tertiary care teaching hospital khammam. Objectives: To determine the knowledge attitude and practice regarding anaphylaxis among dental students based on gender. To determine the knowledge attitude and practice regarding anaphylaxis among dental students based on year of study. Method :A cross sectional study was conducted among dental students (I, II,III ,IV,Interns)in a tertiary care teaching hospital khammam using a web based tool called forms pro a semi structural online questionnaire was designed and distributed to students in order to fill , Descriptive studies and chi square test were calculated using SPSS version 29. Result: A total of 201 students took part with females (57. 7%)and males(42.3%).Age of participants ranges from 19--25 years .In this study females have more knowledge regarding anaphylaxis than males among dental students Interns have more knowledge followed by IV year students followed by III year students, followed by I year students ,followed by IIyear students. Conclusion:The study result suggest that the knowledge attitude and practice regarding anaphylaxis among dental students is adequate.