bluuebunny/crossref_metadata_2025 huggingface dataset:
Antioxidative and Anti-photooxidative Potential of Interruptins from the
Edible Fern Cyclosorus terminans in Human Skin Cells
Authors: Chaiwong Suriya , Sretrirutchai Somporn , Sung Jong-Hyuk , Kaewsuwan Sireewan
Published: June 2023

Background:

Human skin is exposed daily to oxidative stress factors such as UV light,
chemical pollutants, and invading organisms. Reactive oxygen species (ROS) are intermediate
molecules that cause cellular oxidative stress. In order to survive in an oxygen-rich environment,
all aerobic organisms, including mammals, have evolved enzymatic and non-enzymatic defence
systems. The interruptins from an edible fern Cyclosorus terminans possess antioxidative properties
and can scavenge intracellular ROS in adipose-derived stem cells.

Objective:

This study aimed to evaluate the antioxidative efficacy of interruptins A, B, and C in
cultured human dermal fibroblasts (HDFs) and epidermal keratinocytes (HEKs). Moreover, the
anti-photooxidative activity of interruptins in ultraviolet (UV)-exposed skin cells was investigated.

Methods:

The intracellular ROS scavenging capacity of interruptins in skin cells was measured by
flow cytometry. Their induction effects on gene expression of the endogenous antioxidant enzymes
was monitored using real-time polymerase chain reaction.

Results:

Interruptins A and B, but not interruptin C, were highly effective in ROS scavenging,
particularly in HDFs. Interruptins A and B upregulated gene expression of superoxide dismutase
(SOD)1, SOD2, catalase (CAT), and glutathione peroxidase (GPx) in HEKs, but they only induced
SOD1, SOD2, and GPx gene expression in HDFs. Additionally, interruptins A and B efficiently
suppressed UVA- and UVB-induced ROS generation in both HEKs and HDFs.

Conclusion:

The results suggest that these naturally occurring interruptins A and B are potent
natural antioxidants and therefore may have the potential in the future of inclusion in antiaging
cosmeceutical products.
Low-frequency Electrical Stimulation of the Hippocampus Plays a Role in
the Treatment of Pharmacoresistant Epilepsy by Blocking the PKA-CREB
Pathway
Authors: Huang Yuanxin , Shi Dai , Wu Guofeng , Wang Likun , Ren Siying
Published: June 2023

Objective:

The objective of this study is to study the mechanism of Low frequency electrical
stimulation (LFS) in the treatment of drug-resistant epilepsy by regulating the protein kinase
A (PKA)-cAMP response element-binding protein (CREB) signaling pathway upstream of gamma
aminobutyric acid A (GABAA) receptor.

Methods:

Primary hippocampal neurons were extracted and cultured from fetal rat brains and
randomly divided into the normal control group, PKA-CREB agonist group, and PKA-CREB
inhibitor group. Drug-resistant epileptic rats were established and randomly divided into the
pharmacoresistant group, LFS group, PKA-CREB agonist combined with hippocampal LFS group,
and PKA-CREB inhibitor combined with hippocampal LFS group. The normal rats were in
the normal control group and drug-sensitive rats were in the pharmacosensitive group. The seizure
frequency of epileptic rats was determined using video surveillance. The expression of
PKA, CREB, p-CREB, and GABAA receptor subunits α1 and β2 of each group were detected
using reverse transcription quantitative polymerase chain reaction (RT-qPCR) and western blotting
assays.

Results:

The in vitro expression levels of PKA, CREB, and p-CREB in the agonist group were
significantly higher than those in the normal control group (NRC group), while the expression levels
of GABAA receptor subunits α1 and β2 were significantly lower than those in the NRC group.
The expression levels of PKA, CREB, and p-CREB in the inhibitor group were significantly lower,
while the expression levels of GABAA receptor subunits α1 and β2 were significantly higher than
those in the NRC group. The in vivo seizure frequency was significantly lower in the LFS group
than in the pharmacoresistant group (PRE group). Compared to the LFS group, the seizure frequency
and the expression levels of PKA, CREB, and p-CREB in the rat hippocampus were significantly
higher, and the expression levels of GABAA receptor subunits α1 and β2 were significantly
lower in the agonist group. The results in the inhibitor group were exactly the opposite of those in
the agonist group.

Conclusion:

The PKA-CREB signaling pathway is involved in the regulation of GABAA receptor
subunits α1 and β2. In addition, LFS plays an important role in increasing GABAA receptor expression
by regulating the PKA-CREB signaling pathway.
Early Blockage of Mycobacterium Tuberculosis Cell-wall Synthesis via
EchA\6 Inhibition to Overcome Resistance Strain: Insights from Umbrella
Sampling Simulations
Authors: Askandar Rafee Habib , Sharifi Farhad , Shayan Sepideh , Mohammadi Helya , Rahimi Arian , Ardalan Noeman , Mohammed Heshw Farhad
Published: June 2023

Background:

Tuberculosis (TB) has long been the major infectious cause of mortality, ranking higher than HIV/AIDS as the most common cause of death from a single infectious agent worldwide. The EchA6 target of mycobacteria plays a vital role in synthesizing an important component of the mycobacterial outer membrane. The failure of TB treatment has prompted the investigation of novel anti-tubercular drugs.

Objective:

This study was aimed at blockage of Mycobacterium tuberculosis cell-wall synthesis via EchA6 inhibition to overcome resistance strain.

Methods:

Over 3,000,000 compounds and GSK951A (positive control) were investigated as the
inhibitors in this study. The GROMACS molecular dynamic package was used to analyze the protein-
inhibitor complex's conformational changes under constant temperature and pressure. Also,
umbrella sampling (US) was used for free binding energy (ΔG) calculation.

Results:

Four compounds were chosen for the docking investigation. According to the MD analysis, the studied inhibitors demonstrated good stability and flexibility. According to ∆G obtained from US, the ∆G of GSK951A, ZINC11815220, ZINC67770050, ZINC55048326, and ZINC89700914 were -6.14 kcal mol-1, -5.25 kcal mol-1, -10.19 kcal mol-1, -8.55 kcal mol-1, and -8.37 kcal mol-1, respectively.

Conclusion:

In conclusion, ZINC67770050 is recommended for further study in the laboratory. This investigation is an important starting point for discovering anti-tubercular drugs using EchA6 inhibition.
The Analgesic Effect of Ginger on Postoperative Pain: A Systematic
Review of Clinical Trials
Authors: Farsani Hamidreza Azizi , Heidari-Soureshjani Saeid , Sherwin Catherine MT , Tafrishinejad Arash , Azadegan-Dehkordi Zahra
Published: June 2023

Introduction and Aim:

Pain is a common problem that can negatively affect patients' daily life
and impair the quality of life of patients. This systematic review evaluates ginger's analgesic effects and
underlying mechanisms in postoperative pain.

Methods:

An extensive search was undertaken in various databases, including Cochrane Library, Pub-
Med, Embase, Web of Science, and Scopus. After considering the study's inclusion and exclusion criteria,
12 records were retrieved. The raw data were extracted and entered into an Excel form, and the study
outcomes were analyzed. A PRISMA 2020 flow diagram illustrates the direct search approach used for
this systematic review.

Results:

The reviewed studies mainly examined ginger's analgesic effects and other chemical analgesics,
such as ibuprofen. Ginger and its bioactive compounds, such as gingerols and shogaols, can reduce postoperative
pain by relieving nociceptive, mechanical, and neuropathic pain inflammatory pain by activating
the various descendent inhibitory pathways of pain. Ginger induces its postoperative analgesic effects by
involving and changing thinly myelinated A-delta, unmyelinated C-fibers, and myelinated A-beta-fibers,
Transient receptor potential vanilloid 1 (TRPV1), and inhibiting inflammatory process and oxidant activities.

Conclusion:

Ginger is emerging as promising analgesic effects through various nociceptive pathways on
postoperative pain in patients. Additional rigorous clinical trials are warranted to investigate these results
further.
Esophageal Foreign Body Removal by Bile Duct Stone Removal Baskets
(Litho crush): Think out of the Box; A Case Report
Authors: Jat Shankar Lal , Mathur Amit
Published: June 2023

A foreign body or food bolus impaction in the gastrointestinal tract is a common occurrence in emergency endoscopy. In 80-90% of patients, the foreign body will pass spontaneously through the gastrointestinal tract without complications, and in 10-20% of the patients, an endoscopic or surgical intervention is deemed necessary. We report an unusual case of a foreign body, a large mango seed, that was stuck at the level of the mid-esophagus and was refractory to removal by standard endoscopic techniques.
Antimicrobial Potential of Mushrooms: Emergence of Mycotherapy
Authors: Tiwari Pandey Aprajita , Pandey Ishan , Tripathi Prashasti , Mishra Vartika , Yadav Priyanka , Prasad Singh Mohan
Published: June 2023

The 21st century enters a “post-antibiotic world,” with just a few alternatives
for combating antibiotic-resistant microbial strains. The search for new antimicrobials
which could overcome the situation of antimicrobial resistance is of prime importance
and the need of hour. Herbal antimicrobials pose a plethora of new antimicrobial drug
discoveries. Mushrooms give rise to a number of bioactive chemicals that are known to
have anti-pathogenic qualities as well as safer and more effective therapeutic effects in
the treatment of human diseases. As a result, this chapter emphasises that
mycoconstituents might be an alternate treatment regimen and could play a role in
novel drug discovery against various infections. This chapter contains information
about the potential use of mycoconstituents in the management and treatment of
infectious diseases. The approaches illustrate the importance of primary screening of
bioactive molecules from mushrooms as a potential step by offering new possibilities
for clinical and pharmacological research and development. Traditional antibiotics can
now be substituted with newer and more effective natural antimicrobials derived from
mushroom extracts to treat a variety of fatal and multi-drug resistant infectious
diseases. As a result, this functional food extract might play a significant role in
naturally combating infections and offering a comprehensive approach to treatments.
Finally, we will go through the mechanics of mushroom antimicrobial potentials and
presents an insight into Mycotherapy.
In silico Interactions of the Biomolecules of Edible Mushrooms Against Lifestyle Diseases
Authors: Singh Nidhi , Singh Veer , Prasad Singh Mohan
Published: June 2023

Mushrooms are fungi that are consumed all over the world and contain
bioactive nutritive components with nutritional and therapeutic qualities. Protein,
minerals, vitamins and antioxidants are all found in edible mushrooms. Selenium,
vitamin C, and choline are antioxidants that help the human body remove free radicals.
Antimicrobial, antiviral, anticancer, anti-allergic, immunomodulation, anti-inflam.matory, anti-atherogenic, hypoglycemic, hepatoprotective, and antioxidant properties
of mushrooms. Primary and secondary metabolites can be found in mushrooms. The
primary metabolites are energy-producing, but the secondary metabolites have
therapeutic qualities. As the bioactive molecule has a pharmacological effect,
researchers have recently focused on extracting it. As a result, the mushroom has the
potential to be a recipe for human health and play a key role in the battle against
COVID-19 pandemics and other infectious illnesses. Mushrooms and their
biomolecules have therapeutic properties in a variety of diseases, including
cardiovascular, diabetes, reproductive problems, cancer, and neurological disorders. A
computer method, or in silico technology, is promising early evidence for drug
development. Molecular docking studies have discovered bioactive chemicals from
natural items like mushrooms as possible inhibitors against various diseases.
Application of Fungal Xylanase Enzymes
Authors: Jha Harit , Arora Ragini
Published: June 2023

The enzyme xylanase breaks down the linear polysaccharide β-1,4-xylan
into xylose, therefore breaking down hemicellulose, one of the primary components of
plant cell walls. It is essential for the breakdown of plant materials into usable nutrients
by microorganisms that thrive on plant sources. Fungi, bacteria, yeast, marine algae,
protozoans, snails, crustaceans, insects, seeds, and other organisms generate xylanases.
However, the amount of xylanase produced by fungal cultures is generally significantly
larger than that produced by yeasts or bacteria. There is a growing demand for low-cost
microbial xylanolytic enzymes that have industrial uses and are commercially
manufactured. The chlorine-free whitening of wood pulp preparatory to the
papermaking process and the enhanced digestibility of silage are two commercial
applications for xylanase. Aside from the pulp and paper industry, xylanases are used
in wheat flour for ethanol production, improving dough handling and quality of baked
products, as food additives in poultry, clarification of fruit juices, biofuel production,
textiles, pharmaceuticals, and chemical industries. Improved knowledge of the
biological characteristics and genetics of fungal xylanase will allow these enzymes to
be used in a variety of novel biotechnological and commercial applications.
Introduction to Blockchain Technology
Authors: Devi N. , Rani P.L. , Gokul A.R.G.
Published: June 2023

A blockchain is a linked set of records maintained in a decentralized
environment. The records in blockchain are publicly available but cryptographically
secured. The interesting property exhibited by blockchain is that once some
information is recorded, it is infeasible to modify the information. Blockchain is
generated as a chain of blocks that contains time-stamped digital documents so that it is
infeasible to back date them or tamper the documents. These time-stamped digital
documents are stored as a collection of records and grouped as a set of blocks,
chronologically linked in order of time.
A new block is created and appended to the existing blockchain, whenever there is a
need for updating the blockchain. Every block in the blockchain comprises of a hash of
the preceding block, collections of records of its own, and the hashed value records
known as merkle tree. The information inside the blocks varies depending on the nature
of blockchain. For example, when the nature of blockchain is bitcoin, they are
supposed to store the details about a transaction viz., sender, receiver and amount of
coins where as blockchain used for medical records stores the complete health history
of a patient over time. Since blockchain is stored in a distributed way, efficient hashing
techniques are used to ensure the integrity and robustness of blockchain. This chapter
describes the nuances of blockchain technology along with the protocol stack and the
most common consensus mechanisms. Furthermore, recent advances, challenges and
future trends of blockchain are discussed.
Ransomware: Rising Threat of New-Age Digital Extortion
Authors: Bhardwaj Akashdeep
Published: June 2023

What if someone stopped you from accessing your files or using your
computer? What if they demanded an amount to get access back to you? Most financial
and social interactions revolve around three critical aspects – firstly, the use of digital
data and files; secondly, computer systems; and last, the insecure internet. This is
where Ransomware using Bitcoin has become a major cause of concern in the form of
a new-age digital extortion threat to home and corporate users. This chapter discusses
Ransomware and the methods adopted by cybercriminals for holding ransom innocent
users' digital data and systems and proposes a malware detection system. Crypto and
Locker ransomware is reviewed for their propagation, attack techniques, and new
emerging threat vectors, such as file Encryption Ransomware, Screen Lock
Ransomware, Windows & Browser Lock, Pop Advertisements, and URL Redirection.
The author proposed a Cloud-based malware detection system, performing comparison
evaluation with and without the proposed anti-malware solution in the form of
sandboxes, so even if the environment got compromised, it could be easily
decommissioned and rebuilt from a fresh, clean virtual snapshot. Malware Behavioral
environments were set up for analyzing malware before and after receiving malware
payload files and logs from infected user devices. Malware Code Analysis gathered
assembly code and memory dumps from memory and performed analysis on malware
payload instructions. Reporting environment analyzed Web URLs proactively for
malicious sites hosting malware code or payloads and checked the user system and
devices for before and after analysis logs.
Review of Solutions for Securing End-User Data Over Cloud Applications
Authors: Bhardwaj Akashdeep
Published: June 2023

With more and more organizations working on the cloud over unsecured
internet, sharing files and emails and saving them on cloud storage is imperative.
Securing the end-user sensitive data in transit has thus started to get maximum priority
to protect it from Cloud company staff, hackers, and data thieves. In this study, an
attempt is made to review the research on end-user data security. There is an urgent
need for solutions for end-users data protection privacy during the times when
migrating from one cloud service provider to another. This chapter reviews the
challenges in Cloud computing services regarding end-user data, analyzes the issues
face, and presents solutions to overcome them. The chapter identifies end-users data
security issues when using cloud computing services. The focus is directed to critical
issues related to unauthorized access to integrity during data in transit. This can be
addressed using Public Key Cryptography or PKI. For Confidentiality and Data
Integrity for end-user data over Cloud. Then for migrating from one cloud service
provider to another, data security and privacy are addressed by Cloud-aware
applications. Lastly, using Multi-Factor Authentication combined with network and
application detection systems, Intrusion Detection Systems, and Network traffic routing
in case of cyber-attacks can help achieve denial of service attack mitigation or prevent
man-in-the-middle and network snooping in Cloud Computing.
DDoS Attacks, New DDoS Taxonomy, And Mitigation Solutions
Authors: Bhardwaj Akashdeep
Published: June 2023

Cloud computing has started to gain acceptance for adoption and
implementation among organizations, however, this new technology area has already
started to deal with security, performance, and availability challenges. Within Cloud
Security issues being paramount for corporates, and private enterprises, the denial of
service attacks are rated as the highest priority threat to the cloud environments. This
chapter presents a review of the academic literature research work on the DDoS attack
on the Cloud, introduces a new DDoS Classification taxonomy, and proposes
parameters for determining an effective DDoS solution.
Efficient Fault Tolerance in Cloud Environments
Authors: Bhardwaj Akashdeep
Published: June 2023

With mission-critical web applications and resources being hosted on cloud
environments, and cloud services growing fast, the need for having a greater level of
service assurance regarding fault tolerance for availability and reliability has increased.
The high priority now is ensuring a fault-tolerant environment that can keep the
systems up and running. To minimize the impact of downtime or accessibility failure
due to systems, network devices, or hardware, the expectations are that such failures
must be anticipated and handled proactively, quickly and intelligently. This chapter
discusses the fault tolerance system for cloud computing environments and analyzes
whether this is effective for Cloud environments.
New Age Cyber Threat Mitigation for Cloud Computing Networks
Authors: Bhardwaj Akashdeep
Published: June 2023

Increasingly global and online social interactions and financial transactions involve digital data, computing devices and the internet. With cloud computing, remote computing, enterprise mobility and e-commerce on the rise, network security has become a priority. Selecting an appropriate algorithm and policy is a challenge for computer security engineers, as new technologies provide malicious users with opportunities to intrude into computer networks.

New Age Cyber Threat Mitigation for Cloud Computing Networks provides cloud and network engineers answers to cybersecurity challenges. It highlights new options, methodologies and feasible solutions that can be implemented in cloud architecture and IT Infrastructure, thereby securing end users. Chapters cover many topics related to cyber threats in the modern era.

These topics include:

- Ransomware and DDoS attacks

- Security algorithms

- Design and implementation solutions for resilient and fault-tolerant cloud and network services

- Security policy

- End user data security

The book is an essential resource for anyone involved in cloud computing and network security, including learners, professionals and enthusiasts.
Design and build an internet of thing (IOT) solar panel monitoring and solar tracking system
Authors: Nugraha Made Dika , Mahabojana Kadek Agus , Prabawa Nyoman Angga
Published: June 2023

Nowadays, solar panels as a solar power plant which is a renewable energy source requires a tool to monitor the solar panel system. Solar panels can be controlled automatically by a tracking system using microcontroller instrumentation technology. A monitoring and solar tracking system has been designed and built using Arduino Uno R3 microcontroller, Node MCU ESP 8266, Humidity Sensor DHT-11 and PZEM-004T V3.0 based on Internet of Thing (IoT) displayed on smartphone communication devices using Blynk software. Tool testing was carried out in South Denpasar. The research methodology consists of literature study, development of the first system to system refinement and system testing at one point of the building without any hindrance. The results of this study are that the Solar Tracking System shows that the LDR sensor readings are very responsive in receiving sunlight which functions to drive servo motors and the tool can monitor Solar Panels and read the characteristic value of the relationship between light intensity, temperature, load on the measurement results will be displayed on Blynk application menu that has been designed and generated power. The power output generated from the tracker is greater than without a solar tracker.
Listado florístico y comunidades vegetales de la microcuenca Estero del Yugo, Mazatlán, Sinaloa, México
Authors: Ruiz Marcela
Published: June 2023

Antecedentes y Objetivos: La vegetación costera de Mazatlán, México, ha sido escasamente estudiada debido a su remoción, que ha sido provocada por la intensa transformación del entorno para el desarrollo inmobiliario, turístico, comercial, portuario y pesquero. Sin embargo, la microcuenca Estero del Yugo posee uno de los últimos fragmentos de selva seca en la zona urbana, que podría revelar la biodiversidad que tenía la ciudad de Mazatlán antes de la urbanización. Los objetivos de este trabajo fueron analizar y documentar la información generada durante 25 años en el herbario HCIAD del Centro de Investigación en Alimentación y Desarrollo, A.C. (CIAD) para la microcuenca Estero del Yugo, describir las comunidades vegetales y presentar el inventario florístico, con la finalidad de contribuir a futuros programas de conservación y manejo del área de estudio.
Métodos: Se analizaron los registros de plantas vasculares del HCIAD (1996-2022), incluyendo observaciones en campo georreferenciadas. Los ejemplares fueron identificados con la ayuda de especialistas, y con la consulta de bibliografía y ejemplares en plataformas digitales.
Resultados clave: La flora comprendió 75 familias, 275 géneros y 393 especies de angiospermas, obtenidos de 756 registros de colecta y 1000 observaciones en campo. Fabaceae (57 spp.), Cyperus (12 spp.) y Bromelia pinguin (35 registros) fueron los taxones mejor representados. Se reconocieron 42 especies endémicas de México, 21 regionales y 3 exclusivas de Sinaloa; además, cuatro nuevos registros para el estado. Las comunidades vegetales presentes en la zona son selva baja caducifolia, matorral tropical costero, manglar, nenúfar, tular, popal, vegetación de dunas costeras, halófila y urbana. También se registró una población costera relicta de Piranhea mexicana.
Conclusiones: La flora vascular de la microcuenca Estero del Yugo representa 10% de la flora de Sinaloa. Por su belleza escénica, importancia socioecológica y comunidades vegetales gravemente amenazadas en esta zona, debería conservarse como reserva natural municipal.
Development of enhanced primer sets for detection of Norovirus and Hepatitis A in food samples from Guayaquil (Ecuador) by reverse transcriptase-heminested PCR
Authors: Salazar E. J. , Guerrero M. J. , Villaquiran J. A. , Suárez K.S. , Cevallos J.M.
Published: June 2023

Norovirus (NV) is an infectious biological agent that causes gastrointestinal problems of the original nonbacterial appearance of foodborne illnesses. The genotype of NV responsible for the most frequent NV disease outbreaks is GII, accounting for 60–80% of the cases. Moreover, original and new NV variants are continuously emerging, concurrent with the recent global increase in NV infections. Hepatitis A virus (HAV) is another foodborne pathogen frequently implicated in acute gastroenteritis cases around the world. The virus is transmitted among humans via the fecal-oral route, and infection by HAV causes the most severe form of viral illness acquired from foods. In this study, we implemented primer sets to detect NV genotypes I and II. We also developed primer sets for the detection of HAV. The primers were used in a heminested reverse transcriptase PCR (hnRT-PCR) protocol that was rapid and sensitive for detecting NVG1, NVGII and HAV virus in food. The hnRT-PCR was applied successfully to strawberries and spinach obtained from a local fresh-food market, where we could see NVGI, NVGII and HAV.
Keywords: Norovirus1; Hepatitis A2; gastroenteritis3; genotypes4; NVG15; NVGII6; hnRT-PCR7.
Survival and Trends in Annualized Hazard Function by Age at Diagnosis Among Chinese Breast Cancer Patients Aged ≤40 Years: Case Analysis Study
Authors: Wang Jun , Luo Ting , Xiang Zhong-zheng , He Ming-min , Zeng Yuan-yuan , Yang Tian , Wei Xiao-yuan , Yu Siting , Dai Ze-lei , Xu Ning-yue , Tan Chen-feng , Liu Lei
Published: June 2023

Background

Young breast cancer patients are more likely to develop aggressive tumor characteristics and a worse prognosis than older women, and different races and ethnicities have distinct epidemiologies and prognoses. However, few studies have evaluated the clinical biological features and relapse patterns in different age strata of young women in Asia.

Objective

We aimed to explore survival differences and the hazard function in young Chinese patients with breast cancer (BC) by age.

Methods

The patients were enrolled from West China Hospital, Sichuan University. The chi-squared test, a Kaplan-Meier analysis, a log-rank test, a Cox multivariate hazards regression model, and a hazard function were applied for data analysis. Locoregional recurrence–free survival (LRFS), distant metastasis–free survival (DMFS), breast cancer–specific survival (BCSS), and overall survival (OS) were defined as end points.

Results

We included 1928 young BC patients diagnosed between 2008 and 2019. Patients aged 18 to 25, 26 to 30, 31 to 35, and 36 to 40 years accounted for 2.7% (n=53), 11.8% (n=228), 27.7% (n=535), and 57.7% (n=1112) of the patients, respectively. The diagnosis of young BC significantly increased from 2008 to 2019. Five-year LRFS, DMFS, BCSS, and OS for the entire population were 98.3%, 93.4%, 94.4%, and 94%, respectively. Patients aged 18 to 25 years had significantly poorer 5-year LRFS (P<.001), 5-year DMFS (P<.001), 5-year BCSS (P=.04), and 5-year OS (P=.04) than those aged 31 to 35, 26 to 30, and 36 to 40 years. The hazard curves for recurrence and metastasis for the whole cohort continuously increased over the years, while the BC mortality risk peaked at 2 to 3 years and then slowly decreased. When stratified by age, the annualized hazard function for recurrence, metastasis, and BC mortality in different age strata showed significantly different trends, especially for BC mortality.

Conclusions

The annual diagnosis of young BC seemed to increase in Chinese patients, and the distinct age strata of young BC patients did not differ in survival outcome or failure pattern. Our results might provide strategies for personalized management of young BC.
Implementasi Kontrol PID pada Kopel Motor DC dengan Menggunakan Filter Kalman
Authors: Nurrahma Salima , Berbudi Tegar Arif , Firdaus Muhammad Rakha , Izzaulhaq Galang , Hudati Imroatul
Published: June 2023

This paper describes a DC motor clutch system that uses  control methods PID and uses a Kalman filter. The methods used aim to obtain stable results from the DC motor coupling system used. To get the appropriate results, several stages were carried out such as hardware design where this process was carried out by pairing all the components used including the power supply, DC motor driver, Arduino Uno, potentiometer and the two coupled DC motors. This system uses an input voltage of 12 V and will then be processed by the motor driver to drive the DC motor. Based on the results that have been obtained and the system response after being given control. It can be observed that when the system uses the Kalman filter and uses the PI control the system response results have a small steady state error.
Combating Trauma Through a Family Approach in Celeste Ng’s Everything I Never Told You
Authors: Siqi Huang
Published: June 2023

The novel Everything I Never Told You by contemporary Chinese-American author Celeste Ng portrays the challenges faced by a cross-cultural family consisting of James Lee, a Chinese-American university professor, and his white wife Marilyn, in 1970s America. She explores the intergenerational trauma caused by cultural conflicts. Centered around the death of their daughter Lydia, the novel delves into the intergenerational trauma experienced by the members of this cross-cultural family due to familial and societal conflicts. It also depicts how the family members rebuild trust, reconcile with each other, and heal from their trauma. Through this portrayal, the novel highlights the pressing need, amidst cultural clashes and social transformations, to embrace an inclusive and forward-looking perspective to embrace and adapt to the transformative changes.
КАК НАМ РАЗВИВАТЬ ОТЕЧЕСТВЕННУЮ МИКРОЭЛЕКТРОНИКУ: 2023 ГОД
Authors: Эннс В.
Published: June 2023

В статье обсуждаются первоочередные задачи, стоящие перед отечественной микроэлектронной отраслью сегодня, пути преодоления возникающих проблем. Рассмотрены меры по импортозамещению ЭКБ в современных условиях, а также вопросы организации разработки и производства интегральных микросхем.
АНАЛИЗ ПЕРСПЕКТИВНЫХ НАПРАВЛЕНИЙ ДЛЯ СОЗДАНИЯ ИННОВАЦИОННОГО БИЗНЕСА В РФ
Authors: Левалдс Я.
Published: June 2023

Дано краткое описание приоритетных для России направлений развития науки и технологий. На примере направления транспортных систем показан вариант анализа общемировых тенденций и локальной специфики, позволяющего выбрать конкретный сегмент рынка, перспективный в настоящее время для создания отечественного инновационного стартапа.
Detection of Various Accelerants Found in Arson Cases: Implications for Fire Investigation
Authors: Banyal Aditya
Published: June 2023

Abstract: Arson cases pose significant challenges to fire investigators due to the deliberate use of accelerants, which are substances that promote and expedite the spread of fire. This research paper presents an analysis of various accelerants commonly found in arson cases and explores their implications for fire investigation. The study involved a comprehensive review of existing literature, case studies, and experimental analysis of accelerant samples collected from real arson incidents. The research aims to provide a deeper understanding of the characteristics, detection methods, and forensic significance of accelerants. The analysis includes a wide range of accelerants, such as gasoline, kerosene, alcohols, and other flammable liquids commonly utilized in arson incidents. Factors affecting the selection, application, and identification of accelerants are examined, including their volatility, residue patterns, and the influence of environmental conditions. Key findings reveal the importance of accurate and timely identification of accelerants in arson investigations. The study highlights the significance of forensic techniques like gas chromatography-mass spectrometry (GC-MS) and Fourier-transform infrared spectroscopy (FTIR) in identifying and analysing accelerant residues. Moreover, the paper emphasizes the crucial role of collaboration between fire investigators, forensic experts, and law enforcement agencies to effectively interpret and present the findings in a court of law.
Ecological Tourism as a Tool for Sustainable Urban Development Case Study: El Kantara, Algeria
Authors: Lebbal Fatima Zohra , Bensmina Latoui
Published: June 2023

Abstract: Purpose. Tourism has a favorable impact on the economic development of a country. However, research now agrees that this also leads to the destruction of the ecological environment in which it is established. Its management operates increasingly with reference to the concept of sustainable tourism. The objective of this article is to propose a sustainable scenario of a transformation of the red village of the city of El Kantara into an ecological-tourist village. Results. Ecological tourism plays an important role in sustainable urban development, the creation of a micromobility in the propose of ecological-tourism scenario taking into account the notion of the architectural walk in the site of El Kantara, which is rich in heritage, this scenario depends on gentle and non-polluting transport by the application of the method HQE²R which crosses the various dimensions of sustainable development with certain principles of action allowing the transformation of simple district to eco-district. Scientific novelty. The scientific novelty of the study lies in the improvement of the proposal ecologic scenario for El kantara site on the basis of encouraging the concept of sustainable transportation and eco-tourism. Practical value. The value of the study lies in the proposal of a new development technique on an urban scale, which is development through ecological tourism.
Finding Missing Person Using AI
Authors: Raj Ankesh
Published: June 2023

Abstract: The paper focuses on leveraging the power of Artificial Intelligence (AI) algorithms, specifically Convolutional Neural Networks (CNN) for image classification, along with the Python programming language and the Telegram messaging platform for real-time notifications. The objective is to enhance the efficiency and effectiveness of search and rescue operations by utilizing AI techniques to detect missing persons using surveillance cameras. This research aims to harness the potential of AI, particularly in facial recognition, to improve the accuracy and speed of identifying and locating missing individuals, thereby aiding in search and rescue efforts..
Strength of Quick Response Code in Smart Billing System
Authors: Khedekar Lokesh , Vasmatkar Parimal , Sahu Varun , Ghote Varad , Vartak Kedar , Vaskar Siddharth , Mahajan Vasu
Published: June 2023

Abstract: The daily grocers and retail establishments are the main focus of Smart Billing System. In order to decrease store thefts and improve the effectiveness of the billing system, smart billing systems employing RFID operate on a similar basis. When a consumer wants to purchase a product, they must first scan the QR code located on the back of the item. This will take them to ourapp, where they may view more information about the product and select whether or not to go to checkout.
Apakah Inovasi Hijau Dan Pengungkapan Emisi Karbon Dapat Mempengaruhi Nilai Perusahaan Pada Perusahaan Manufaktur?
Authors: Putri Harvinna Dwi , Agustin Henri
Published: June 2023

The development of the industrial world is currently very competitive with each other, including industries in Indonesia. In addition, developments can cause environmental damage as a result of the company's activities. Therefore, this might have a negative impact on society and lower the company’s worth. The study aims to investigate to link between firm value and green product innovation, green process innovation, and disclosure of carbon emissions. Using purposive sampling criteria, the research sample consisted of manufacturing companies listed on the Indonesia Stock Exchange listed in the PROPER rating from 2017 to 2020, and combined into 30 companies with 115 observations. According to legitimacy, signaling, and stakeholder theory, the study’s findings show that green process innovation and disclosure of carbon emissions have a positive influence on firm value. This shows that manufacturing companies have succeeded in reducing the impact of their activities on the environment and have complied with environmental regulations. Meanwhile, green product innovation has a negative effect on firm value, this is because the participation of manufacturing companies in Indonesia in implementing green product innovation is still low. This research contributes to theory and practice in companies that want to produce environmentally friendly products. The results of these findings can be a reference for investors in making decisions.
Eksplorasi Sustainable Development Goals (SDGs) Disclosure Di Indonesia
Authors: Wicaksono Agung Prasetyo Nugroho
Published: June 2023

SDGs (Sustainable Development Goals) is a global development agenda that aims to alleviate problems in the social, economic, environmental, as well as legal and governance fields to ensure the quality of human life in a sustainable manner. This study seeks to explore the disclosure of SDGs in companies from various sectors in Indonesia. Sampling using purposive sampling technique so as to produce 16 companies from 8 sectors as the sample. The analysis method uses content analysis in the 2021 sustainability report which is then explored using matrix coding on Nvivo. The results show that the level of disclosure of the SDGs in Indonesia is very low with an average of 8% based on business action and 20% based on SDGs targets.
BİREYSEL VE TOPLUMSAL HAFIZA BAĞLAMINDA FOTOĞRAF: GÜLSÜN KARAMUSTAFA’NIN SAHNE VE GÜLLERİM TAHAYYÜLLERİM ADLI ESERLERİNE BİR BAKIŞ
Authors: SABANCILAR IŞTIN Duygu , ÇALIŞKAN Serkan
Published: June 2023

Fotoğraf, ânı yakalamakta, o ânı temsil etmekte, o andaki gerçekliği yansıtmakta ve o andaki gerçekliğe göndermede bulunmaktadır. Fotoğraf geçmişte yaşananlara dair bir belge, geçmişi bugüne taşıyan, o âna ve o andaki gerçekliğe dair hafızayı / belleği harekete geçiren bir imgedir. Bir imge ve belge olarak fotoğraf, bireysel ve toplumsal hafızanın hatırlatıcısı, taşıyıcısı ve aktarıcısıdır. Bu makale, Gülsün Karamustafa’nın bireysel bir anıya ait fotoğrafı üzerinden, o fotoğrafı yeniden tekrar üreterek oluşturduğu eserler üzerinden toplumsal hafızaya dair tanıklıklarını incelmeyi ve değerlendirmeyi amaçlamaktadır. Bireysel anlara ve olaylara ait bilgilerin taşıyıcısı olan fotoğraflar, yeniden üretildiklerinde geçmişi bugüne taşıyarak, geçmişe dair belleğin, şu anda da bir sorgulanması için alan açmaktadır. Bununla birlikte geçmişte görünmeyen toplumsal hafızayı, o an ve şu anda ve de gelecekte görünür kılmaktadır. Betimsel modele dayalı nitel bir araştırma modeliyle incelenen bu makalede, sanatçının bireysel fotoğraflarından ürettiği eserleri üzerinden “unutma” ve “hatırlama” arasındaki bireysel ve toplumsal olan arasındaki ilişki incelenmektedir.
FLOW FIELD PLATE DESIGN ANALYSIS WITH CROSS-SECTION WAVE RECTANGULAR SERPENTINE USING 3D FLOW SIMULATION ON PROTON EXCHANGE MEMBRANE FUEL CELL
Authors: Prasetya Teguh Imam , Khaerudini Deni Shidqi
Published: June 2023

The availability of petroleum which continues to decrease and the level of public consumption which is always increasing are serious problems today. Renewable energy needs to be researched on an ongoing basis to anticipate the availability problems above. Proton Exchange Membrane Fuel Cell (PEMFC) is an environmentally friendly source of electrical energy because it only requires hydrogen and oxygen as raw materials and water as a result of the reaction. This study will discuss the PEMFC flow field plate because this component dominates the weight and cost of manufacture. Research on flow field plate PEMFC with wave rectangular cross-section is necessary to develop the PEMFC concept with better performance results. This study aims to determine the effect of the wavy cross-section shape on the distribution of channel average speed, channel outlet speed, inlet pressure, channel average pressure, and channel outlet pressure. This study uses a computational fluid dynamic (CFD) method using SolidWorks flow simulation software. This study provides an overview of the serpentine type of flow field plate with a wave rectangular and rectangular cross-section. The wave rectangular cross-section has a higher average velocity, outlet velocity, inlet pressure, and pressure than the rectangular cross-section. This is what will make PEMFC performance higher. The wave rectangular cross-section has nearly the same number of outlet pressures as the rectangular cross-section. Possible development of this research is the creation of simulation software to calculate other parameters that affect PEMFC performance.
The influence of the COVID-19 pandemic on the spectrum of neonatal disease in a tertiary hospital in China
Authors: Wang Yi , Song LinHong , Ma Ning , Li Hao , Hu Siqi , Feng Zhichun
Published: June 2023

Background: Neonatal diseases are a significant threat to global public
health, resulting in the disturbance of normal homeostatic well-being in
affected patients and reflecting the status of, and challenges to,
regional, national, and global healthcare systems. Objectives: To
investigate the disease spectrum observed among neonatal inpatients
changed after COVID-19 breakout. Methods: The present hospital-based
retrospective study analyzed the demographic and clinical
characteristics of 19,943 newborns who were hospitalized from January
2018 to December 2022 using data derived from pediatric department
registers. Results: According to the ICD-11 classification criteria, the
two most common neonatal disorders during this study period were
“Certain conditions originating in the perinatal period” and “Disease
of the respiratory system”. Following the start of the COVID-19
pandemic, the number of neonatal patients declined markedly, and the
proportion of newborns assigned the “Disease of the respiratory
system” ICD-11 classification similarly decreased. Discusssion and
Conclusions: The present study retrospectively analyzed these neonatal
disease characteristics at our hospital in greater detail, providing a
foundation for future research and policymaking efforts.
Effect of the China NCDP policy on anticoagulation selection and hemorrhage events in patients with AF in Suining
Authors: Zhang Qi , Wang RuiLi , Male Joshua Daniel , Meng Qiu , Ma Hui , Chen Lei , Chen WenSu
Published: June 2023

Background:China began to launch the National Centralized Drug
Procurement(NCDP) policy in March 2019 to improve public hospitals’ drug
use model.After non-vitamin K antagonist oral anticoagulants(NOACs)
entered the purchase list, medical institutions in Suining County of
Xuzhou began widely using NOACs on March 1, 2020. Objective: To
study the effect of the NCDP policy on anticoagulation, medication and
hemorrhage events in patients with non-valvular atrial fibrillation(AF)
in Suining. Methods: In this study, we used the hospitalization
data of the Department of Cardiology of Suining County People’s Hospital
from January 1, 2017 to June 30, 2022. General data collected included
sex, age, type of health insurance, admission year, hospitalization
costs, anticoagulants, use of anticoagulants, etc. Stroke risk
stratification of patients with AF using CHA2DS2-VASc score classified
patients with CHA2DS2-VASC score ≥ 2 as high risk and those with
CHA2DS2-VASC score < 2 as medium and low risk.
Results: 3,986 patients with non-valvular atrial
fibrillation(NVAF) were analyzed in the study. 1. The cost after
procurement was significantly higher for hospitalized patients than it
was before the implementation of the policy(8900.57±9023.02CNY vs
9829.99±10886.87CNY,P<0.001). 2. The proportion of oral
anticoagulants increased significantly after the NCDP
policy(40.02%vs61.33%,P<0.001), especially the use of NOACs
among them(15.41%vs90.99%,P<0.001). 3. The proportion of
patients with hemorrhage events decreased significantly after the
implementation of the NCDP policy(1.88%vs 0.66%,P=0.01). 4. In the 219
re-hospitalized patients, the anticoagulant rate increased significantly
after the NCDP policy(36.07%vs59.82%, P<0.001) ,the use of
NOACs increased significantly among them（11.39%vs80.92%,
P<0.001). 5. Whether the patient changes the type of
anticoagulant or not has nothing to do with age, type of health
insurance, hospitalization cost and antiplatelet. The NCDP
policy[OR=511.703,95% CI(103.879,2520.618), P<0.001] is
the only factor that affects the change of anticoagulant type.
Conclusion: The NCDP policy improves the anticoagulant rate and
drug compliance in patients with AF, and significantly reduces
hemorrhage events.The NCDP policy is the only factor that affects the
change of anticoagulant type.
Rheological Characteristics and Behavior Prediction of Lubricating Grease for an RV Reducer Across a Wide Temperature Range
Authors: Jiang Benchi , zhou zhouyansheng , Tu Zhijian , Pan Jiabao
Published: June 2023

The performance of the RV reducer, a pivotal component in industrial
robots, is greatly affected by the alterations in lubricant properties
under a wide range of operating temperatures (-20℃ to 40℃). This study
explores the rheological characteristics of the synergistic lubricating
grease utilized in RV reducers under such extensive temperature
conditions and applies the Elman neural network model for predicting its
rheological behavior. The research reveals that the entanglement
performance of lubricating grease generally diminishes with rising
temperature. Notably, in the -20℃ to 0℃ range, the entanglement of soap
fibers experiences a significant decrease, with the flow and thixotropic
characteristics exhibiting distinct transformation rules. The accuracy
of the Elman neural network model in predicting the rheological
characteristics of the lubricating grease is found to be equivalent to
that of classical rheological model data fitting methods, indicating a
high degree of predictive accuracy. This method holds reference value
for the precise prediction of the rheological characteristics of
lubricating grease under the influence of various complex factors.
Interstitial (cornual) ectopic pregnancy: Laparoscopic management
Authors: Nguyen Hillary , Rao Svetha , Lok Derek , Rao Tanushree
Published: June 2023

Interstitial ectopic pregnancies account for 2-6% of all ectopic
pregnancies. Compared to classical ectopic pregnancies, interstitial
ectopic pregnancies have a higher mortality rate with a higher
likelihood of causing life-threatening haemorrhage, prompting necessity
for effective surgical intervention. Whilst the open method is commonly
used, emerging laparoscopic methods such as corneal resection and
cornuostomy are minimally invasive and can have additional benefits of
fertility preservation. We describe a case series of two cases using
both corneal resection and cornostomy techniques to manage interstitial
ectopic pregnancies.