bluuebunny/crossref_metadata_2025 huggingface dataset:
Desarrollo y calibración de un modelo matemático para control predictivo de un proceso de esterilización de alimentos sólidos
Authors: Novoa Lorenzo Miguel , Pitarch Pérez José Luís , Taboada Antelo Luís , Vilas Fernández Carlos
Published: August 2024

La esterilización es uno de los procesos más utilizados para incrementar la vida útil de productos de la industria alimentaria. Sin embargo, es un proceso que consume energía y tiempo y que puede resultar en productos inseguros o de baja calidad. El modelado matemático y la optimización de procesos son herramientas útiles para evitar estos problemas.
En este trabajo proponemos un nuevo modelo matemático para la descripción del proceso de esterilización. Nuestra alternativa presenta dos claras ventajas respecto a otros modelos publicados. (1) Es capaz de describir los siguientes fenómenos físicos: cambios de estado discretos derivados de condiciones de no equilibrio entre agua y vapor mediante la ecuación de Fischer-Burmeister; entrada de aire por la purga; y salida de gases por el drenaje. (2) La simulación del modelo es eficiente y permite su uso en un esquema de control predictivo no lineal basado en modelos.
Además, estimamos los parámetros desconocidos del modelo a partir de datos experimentales.
Monitorización del contenido de fósforo del olivo mediante robot terrestre
Authors: Noguera Miguel , Millan Borja , Moro Rocio , Andújar José Manuel
Published: August 2024

El olivar es un cultivo de gran importancia en los países de la cuenca mediterránea. En las últimas décadas, el sector olivarero ha experimentado una modernización en busca de incrementar la rentabilidad y productividad de sus explotaciones. En este contexto, la gestión basada en agricultura de precisión está mostrando un potencial prometedor. En este sentido, el presente trabajo muestra una metodología para la caracterización del contenido foliar de P en olivares superintensivos. El método propuesto se basa en redes neuronales artificiales alimentadas con información espectral extraída de imágenes adquiridas por un robot terrestre con capacidad para la navegación autónoma. Para evaluar la metodología propuesta se definió un planteamiento experimental basado en exponer una parcela de olivos superintensivos a tratamientos de fertirriego diferenciales para generar variabilidad en cuanto al contenido foliar de P.  El índice de correlación entre los valores de obtenidos por análisis químico y la respuesta del modelo (R2=0.72) sugieren la idoneidad de la metodología propuesta.
Diseño y construcción de una órtesis de codo inteligente
Authors: Villanueva Pelayo Marina , Romero Mirete Cristina , Morell Giménez Vicente , García Gómez Gabriel J. , Úbeda Castellanos Andrés , Jara Bravo Carlos A.
Published: August 2024

En este artículo se presenta el diseño, construcción y programación de una órtesis de codo inteligente para tratar la rigidez articular del codo, una complicación común después de traumatismos o accidentes cerebrovasculares. Mediante impresión 3D, se ha creado un dispositivo fácilmente adaptable a cada paciente, con 3 grados de libertad que permiten la flexoextensión y pronosupinación del brazo. Además, incluye una articulación diseñada para descargar la concentración de fuerzas en el codo durante los movimientos de flexión y extensión. Mediante sensorización, la órtesis mide con precisión los ángulos de flexoextensión y pronosupinación, y gracias a su interfaz en pantalla se puede ver la evolución del movimiento del paciente en tiempo real. Para resolver los problemas de motivación de los pacientes tras recibir el alta hospitalaria, la interfaz incluye un pequeño juego que además sirve para generar un informe detallado con la información más importante para el personal sanitario, facilitando así el seguimiento y ajuste del tratamiento.
Control robótico inteligente para extracción de elementos flexibles
Authors: Tapia Sal Paz Benjamin , Sorrosal Gorka , Mancisidor Aitziber , Cabanes Itziar
Published: August 2024

La automatización de tareas de desensamblaje presenta grandes desafíos, principalmente relacionados con las caracteristicas dinámicas y no estructuradas de la tarea, en donde se necesitan acciones adaptativas para asegurar la interacción adecuada entre el robot y el entorno de la tarea. En este trabajo se propone un control basado en aprendizaje por refuerzo para la automatización de tareas de extracción de elementos flexibles mediante el uso de robots, buscando así enfrentar las dificultades de trabajar en estos entornos desestructurados y dinámicos. Para lograr eso, el control propuesto aprenderá a tomar acciones adecuadas en el movimiento del robot que llevarán a la extraction de elementos flexible a través de trayectorias de baja fuerza. Como resultado, este trabajo demuestra cómo la integración de un controlador basado en aprendizaje por refuerzo puede abordar los desafíos de la extracción de elementos flexibles, contribuyendo asi al avance de procesos de desensamblaje inteligentes mediante el uso de robots.
Integración de IMU y GNSS. Estimación del estado del firme
Authors: Díaz-Cacho Medina Miguel , Chaves André , García Rivera Matías
Published: August 2024

Este trabajo presenta un sistema de integración de sensores proporcionada por un dispositivo móvil para entornos vehículares. Los sensores integrados son un IMU y un receptor GNSS, que permiten crear un sistema de estimación del estado del firme basado en la variación de la aceleración vertical detectada por el IMU y asociarlo a unas coordenadas geodésicas. Para dotar al sistema técnico de un marco teórico se definen unidades específicas de rugosidad basándose en las muestras de la aceleración medida e inspiradas en las técnicas tradicionales de medida de rugosidad de superficies. El sistema se sirve de una topología ITS tradicional, donde el dispositivo móvil es la OBU con capacidad de transmisión de datos al servidor C-ITS en la nube para ser procesados y determinar los parámetros resultantes. Se realizaron pruebas del sistema en un entorno viario real con resultados satisfactorios, donde se detectaron diferencias en los tipos de firme y hendiduras en la calzada.
Modelos a gran escala para mapeo semántico en robótica móvil
Authors: Moncada Ramírez Jesús , Ruiz-Sarmiento José Raúl , Matez-Bandera José Luis , Gonzalez-Jimenez Javier
Published: August 2024

La aparición de los modelos a gran escala permite abordar algunas de las principales limitaciones que presentan las técnicas de mapeo semántico tradicional en robótica móvil. Sin embargo, estos modelos son propensos a generar respuestas incorrectas, incoherentes o incluso inventadas, pudiendo ocasionar comportamientos erróneos del robot. Para poder desplegarse en aplicaciones reales, por tanto, es crucial desarrollar mecanismos que permitan mitigar estas errores. En este trabajo se utiliza \textit{ConceptGraphs}, un método del estado del arte basado en modelos a gran escala para construir mapas semánticos, sobre el que se plantean dos estrategias para reducir las respuestas erróneas. Primero, se propone adaptar el método para operar con modelos más recientes (por ejemplo, Gemini 1.5 y ChatGPT-4o). En segundo lugar, se incorpora una etapa de refinamiento de respuestas mediante la técnica denominada \textit{Reflexión}, que permite al modelo autoevaluar y mejorar sus propias respuestas. Finalmente, se validan las propuestas mediante experimentos en entornos reales del conjunto de datos ScanNet.
Guante vestible para la detección de gestos usando sensores inerciales
Authors: Benito Martínez Alba , Bernat Iborra Lluís , García Gómez Gabriel Jesús , Ramón Carretero José Luis , Jara Bravo Carlos Alberto , Úbeda Castellanos Andrés
Published: August 2024

En este artículo se presenta un guante vestible que permite obtener la información de las posiciones relativas de la mano mediante la incorporación de varios sensores inerciales que registran los ángulos de movimiento de los dedos junto con la orientación de la palma de la mano. El dispositivo se ha validado preliminarmente clasificando tres gestos básicos de la mano con resultados muy prometedores, lo cual indica que el uso del guante es viable para el reconocimiento de un mayor número de gestos. En el futuro, se ampliará la base de datos de gestos clasificados y se incorporarán herramientas en tiempo real de detección para poder aplicarse en la comunicación directa entre personas sordas y su entorno o la evaluación de movimientos en el ámbito de la rehabilitación de la mano
Aproximación a la identificación no paramétrica de sistemas muestreados asíncronamente mediante interpolación de Lipschitz
Authors: Orihuela Luis , Manzano José María
Published: August 2024

En este artículo se presenta una primera aproximación al problema de identificación no paramétrica de sistemas muestreados asíncronamente. La solución propuesta parte, en primer lugar, de la generación de un cuaderno de trayectorias, que se ajustan a partir de los datos asíncronos disponibles. Posteriormente, se presenta un mecanismo de aprendizaje no paramétrico basado en interpolación de Lipschitz. Éste permite realizar predicciones, con error acotado, del valor de los estados del sistema. El mecanismo de aprendizaje, aunque basado en la literatura, es novedoso, al tener que manejar trayectorias n-dimensionales, en vez de vectores de n dimensiones. Se valida el método sobre el sistema dinámico caótico conocido como el atractor de Lorenz.
Michel Henry interprete di Karl Marx: un dialogo sulla vita
Authors: Canullo Carla
Published: August 2024

After the publication of L’essence de la manifestation and his research on Maine de Biran, Michel Henry devoted two volumes to the work of Karl Marx. Published in the 1970s, at a time when Marxism dominated the cultural and political scene, Henry is quick to gloss over the Marxist debate of the time, without interesting for political implications of Marx’s work and questioning it in the light of the phenomenological proposal he had initiated in his early works. In particular, he shows how Marx’s work can be understood if the phenomena he discovers (praxis, history, alienation) are manifested in the horizon of life. In order to grasp this horizon, I will propose to follow the overturing that Henry’s phenomenology enacts; an overturing that is both thematic and more authentically philosophical, aiming to highlight life as the invisible reverse of phenomena. To do this, I will first explain the meaning of the overturing; secondly, I will outline the main lines of Henry’s phenomenological proposal; thirdly, I will introduce in this framework Henry’s reading of Karl Marx’s work.
Revolutionizing Labor: Marx and Michel Henry on the Power of Praxis
Authors: Schaefer Max
Published: August 2024

This paper will address the concept of labor through a study of Karl Marx and Michel Henry. While Henry claims to uncover, against the tradition of Marxism itself, the truth of Marx’s philosophical conception of the human being as a laborer within a social context, I will argue that both Marx and Marxism (i.e., Étienne Balibar) can help rectify certain shortcomings in Henry’s view of the matter. Toward this end, I will begin by laying out Henry’s account of Marx’s theory of labor and demonstrate that it is central to Henry’s phenomenology of life. As part of this, I will show that a proper understanding of the concept of labor goes some way toward undermining the dominant view of Henry’s work as one that neglects the role of the human being’s engagement in the world in life’s transformations. For all that, as I will demonstrate, Henry’s work fails to do justice to the ways in which the living labor of human beings is determined by the world. By analyzing the work of Marx and Balibar, this paper will show that these figures provide insights into the inter-affective, even transindividual, character of labor and thereby help remedy these pitfalls and improve Henry’s account of the nature and function of living labor.
First whole genome sequencing of Escherichia coli carrying mcr-1 from pig in Argentina
Authors: Pellegrini Juan Leandro , Lorenzini-Campos Melina , Lucero Raúl Horacio , Amadio Ariel , Lösch Liliana Silvina , Di Conza José Alejandro , Merino Luis Antonio
Published: August 2024

The objective of this study is to communicate the findings of the first whole genome sequencing of a colistin-resistant Escherichia coli isolate harboring mcr-1 gene obtained from a pig in Argentina. Genomic DNA was sequenced using the MinION Oxford Nanopore platform. The libraries were prepared using a SQK-RBK110-96 protocol. The sequencing process was conducted on a MinION Mk1C MIN 101-C, utilizing a FLO-MIN106 flow cell. The quality of the reads was evaluated using NanoPlot. De novo assembly was conducted using Canu 1.6 and the quality of contigs was evaluated using QUAST. Annotation was performed using Prokka. The CBC20 strain exhibited a colistin MIC of 4 µg/mL. The genome size was 5178653 bp with a GC content of 50,31%. The N50 value was 133,250, while the L50 value was 21. A total of 11,620 genes, 11,518 coding sequences, 77 transfer RNAs and 24 ribosomal RNAs were identified. A serotype O9:H37 with sequence type ST-297 was observed. A total of seven antimicrobial resistance genes were identified, including mcr-1.5, bla TEM-1B, bla EC-18, bla TEM-70, aph(3')-Ia, mph(A) and sul3. The presence of punctual mutations was observed in the genes encoding the proteins GyrA (S83L, D87N) and ParC (S80I). Five distinct plasmid replicon types were identified, including IncFII, IncY, IncFIB, IncX1 and Col440II. Our findings may assist in the comprehension of the mechanisms of antimicrobial resistance, genomic epidemiology and dissemination of mcr-1 gene among animals and environment, which could potentially impact human health.
Horizontal Incomitance and Anisocoria in Congenital Esotropia
Authors: Duarte Martín , Sántibañez Jorge , Salinas Roberto
Published: August 2024

Introduction: When exploring horizontal version movements, the pathways integrating Slow Eye Movements (SEMs) are analyzed, and when exploring pupil behavior, the pupillary pathway is analyzed. In healthy patients, the horizontal version trajectory is concomitant and the difference in size between both pupils is usually not significant, however, in Congenital Esotropia (CE), differences can be significant. Objective: Identify if the type of horizontal incomitance is related to the degree of anisocoria in CE. Materials and Methods: A prospective, cross-sectional, and experimental study was conducted on patients diagnosed with CE from Querétaro, Mexico. Infrared Video-oculography was performed under scotopic conditions (0.3 lux). Signs of congenital stigma such as Dissociated Vertical Deviation (DVD) and Latent Nystagmus (NL) were sought; likewise, the type of Horizontal Incomitance (IH) was classified according to motor behavior. Pupil area was measured using Voxel-based morphometry (VBM) and anisocoria was classified. The results were statistically analyzed. Results: 53 patients aged 5 to 14 years were recruited: 22 boys and 31 girls. 21 patients presented with DVD and 25 with NL. All patients showed abduction limitations to varying degrees. IH had an incidence of 0.698, NL 0.471, DVD 0.396, Passive Horizontal Incomitance (PHI) 0.377, Active Horizontal Incomitance (AHI) 0.320, and No Horizontal Incomitance (NHI) 0.301. Discussion: Both anisocoria and incomitance occur in CE. It is the first time the type of horizontal incomitance has been related to the degree of anisocoria. The analysis suggests a relationship between anisocoria and the type of incomitance, establishing differences between forms with and without Ciancia of CE. This contributes to decision-making and guides diagnosis, as well as prognosis.
Wohlfahrtiimonas chitiniclastica bacteremia: First Documented Case in Morocco and North Africa
Authors: Rafei Ayoub , Oualhadj Hamza , Houmich Taoufik , Hanchi Asmae , Soraa Nabila
Published: August 2024

Background: Wohlfahrtiimonas chitiniclastica is an emerging pathogen associated with severe infections, predominantly found in compromised individuals and often underestimated due to diagnostic challenges. This case report documents the first recorded instance of Wohlfahrtiimonas chitiniclastica bacteremia in Morocco and North Africa, arising from an infected external fixator. Case Presentation: A 24-year-old male presented to the emergency department with signs of severe sepsis. He had been previously treated with an external fixator for an open leg fracture. Despite having no significant past medical history or high-risk lifestyle behaviors, he developed rapidly progressing symptoms including cutaneous necrosis and systemic infection markers. Laboratory tests confirmed hyperleukocytosis, elevated C-reactive protein, and raised procalcitonin levels. Blood and tissue cultures identified Wohlfahrtiimonas chitiniclastica, along with Providencia stuartii and Enterococcus faecalis. The patient was treated in the intensive care unit with broad-spectrum antibiotics initially, followed by targeted therapy based on susceptibility profiles, and underwent surgical debridement of the infection site. Discussion: The identification of Wohlfahrtiimonas chitiniclastica in this case marks an important development in its epidemiological profile. Once thought to be limited to specific regions and vectors, it is now recognized globally, suggesting a wider ecological presence and varied transmission routes. This case notably links the bacterium’s infections to breaches in skin integrity, like wounds and chronic ulcers, highlighting them as primary infection gateways. The use of MALDI-TOF mass spectrometry was crucial for the swift and precise identification of Wohlfahrtiimonas chitiniclastica, proving more effective than traditional biochemical methods. Additionally, 16S rRNA gene sequencing offered valuable insights into the organism's taxonomy and resistance patterns, underscoring the critical role of these advanced diagnostics in modern clinical microbiology. Despite the bacterium's broad susceptibility to antibiotics, vigilance is crucial due to the potential for emerging resistance. This risk is heightened by antibiotic use in chronic wound management, emphasizing the need for continual surveillance and rigorous antibiotic stewardship to prevent therapeutic failures and resistance proliferation. Conclusion: This case highlights Wohlfahrtiimonas chitiniclastica's worldwide distribution and its link to compromised skin integrity. Advanced diagnostics like MALDI-TOF MS and 16S rRNA sequencing proved crucial in identifying this pathogen. The potential for antibiotic resistance necessitates ongoing surveillance and prudent management to control infections and curb resistance. This case reinforces the need to include W. chitiniclastica in differential diagnoses, especially in cases involving skin breaches.
A 21-Year-Old Woman with New Onset Tourette Syndrome after Coronavirus Disease 2019 (COVID-19)
Authors: Munipalli Bala , Morris Anjali , Rummans Teresa
Published: August 2024

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in December 2019 and has affected millions. Many patients who have had coronavirus disease 2019 (COVID-19) infection develop acute and chronic medical illnesses which can impact every organ system. Those who develop new-onset neurological disorders during the acute phase will often experience long-lasting complications. Although the specific cause is unclear, many mechanisms have been cited, including a direct impact from the virus itself and indirect impacts from inflammation, hypoxia, and hypercoagulability. We present a case of an adult with no neurological or psychiatric history who developed a series of neurological issues ending in the development of Tourette Syndrome (TS) after a COVID-19 infection. The patient has continued to display the symptoms of Tourette Syndrome but has improved with the current treatments available for Tourette Syndrome.
The Role of Gut Microbiota in the Development of Type 2 Diabetes Mellitus
Authors: Okobi Okelue
Published: August 2024

Type 2 diabetes mellitus presents a significant global healthcare challenge with a steadily rising prevalence. Recent research has shed light on the correlation between gut bacteria and the improvement or progression of type 2 diabetes. This review article delves into an evaluation of current knowledge of how the gut microbiota affects type 2 diabetes, focusing on the impact of microbial imbalances on insulin resistance, inflammation, and metabolic dysfunction. By evaluating current knowledge in this field, the study highlights the potential of modifying the gut microbiota through food plan adjustments, probiotics, prebiotics, and fecal transplants as a promising strategy for managing type 2 diabetes. Additionally, it explores how specific microbial species and compounds influence glucose metabolism and insulin sensitivity, potentially providing targets for microbiota-focused interventions aimed at ameliorating the burden of type 2 diabetes.
Noninvasive Colour-Based Card for Risk Assessment of Anaemia in Children: PAN-India User Experience
Authors: Kulkarni G , Dekhne J , Rajsekhar B , Kumar A S , Anand T , Garg L K , Chakrabarti K , Mirza A A , Joshi R K , Karthikeyan A G , Yadav B
Published: August 2024

Background: Easy-to-use inexpensive tools are needed for the detection and timely intervention for anemia in children. As an extension of an earlier user-experience in 9 paediatricians, we present real-world experience of 84 paediatricians for the assessment of anemia with the use of the Non-invasive Screening of Anemia (NISA) colour-based shade card in 1459 children aged 6- 60 months. Methods: The NISA shade card was used to determine the presence and severity (mild, moderate, severe) of anemia by comparing the natural colour tint or pallor of palpebral conjunctiva with 13 ordinal shades. A feedback questionnaire was used to assess the experience of using the NISA card. Results were summarized using descriptive statistics. Results: The sensitivity and specificity of the NISA shade card for detection of anemia were 80.83% (95% CI: 72.64% to 87.44%) and 66.04% (95% CI: 51.73% to 78.48%) respectively. The NISA card had an accuracy of 81.28%; this ranged from 77.74% to 85.23% in different regions across India. Most clinicians rated the NISA card as good to excellent for its utility in screening for anemia especially in situations where drawing of blood could be avoided. Conclusion: With an accuracy and sensitivity of >80%, the NISA shade card is a simple tool that can easily be deployed in community settings for the assessment of anemia. The tool can find its extended use in planning and implementing nutritional practices in children.
Pathophysiology of Childhood-Onset Myasthenia: What is happening at the neuromuscular junction?
Authors: Hayashi Masatoshi
Published: August 2024

Myasthenia is caused by abnormalities in signal transduction at the neuromuscular junction. Its pathophysiology which is broadly classified into acquired myasthenia gravis and congenital myasthenic syndrome has been elucidated and its treatment has progressed over the past half century. Childhood-onset myasthenia gravis is less common than adult-onset myasthenia gravis, and therefore the pathophysiology has not been well studied, and treatment has continued to be based on research in the adult setting. However, treatment of children should be based on an understanding of their pathophysiology, and research on pathophysiology and treatment methods that take into account their unique growth and development is desired. In recent years, studies on myasthenia have been reported from around the world, confirming that the pattern of the number of patients by age of onset differs between East Asia and Western Europe, and that the Japanese characteristic of a high incidence in childhood is widely seen in East Asia. Furthermore, differences in the incidence of congenital myasthenic syndrome between East Asia and Western Europe are also evident. Thus, there are racial differences in the pathophysiology of myasthenia based on genetic background, and their pathophysiology and relevance are gradually becoming clear. Congenital myasthenic syndrome is caused by genetic defects in various proteins involved in the assembly of AChRs at the neuromuscular junction, resulting in impaired neuromuscular signaling and the appearance of myasthenic symptoms. On the other hand, myasthenia gravis which is a T cell-dependent, antibody-producing autoimmune disease, is caused by autoantibodies against several proteins, mainly AChR antibodies. These proteins, like congenital myasthenic syndrome, are involved in the assembly of AChRs at the neuromuscular junction. Autoantibodies to these proteins prevent the assembly of AChRs, resulting in myasthenic symptoms due to the inability of neuromuscular signaling. The ocular muscle type, which is common not only in Japan but also in East Asia, has low antibody titers and seronegative MG is relatively common. In this review, I would like to summarize and discuss what is happening at the neuromuscular junction in myasthenia, especially the pathophysiology of myasthenia gravis with low antibody titers from various viewpoints, such as the presence of antibodies to neuromuscular junction proteins, the inability to measure antibody titers due to measurement sensitivity issues, diversity by muscle site or type, or involvement of cellular immunity.
A case of Merkel cell carcinoma
Authors: Kalluri Sowjanya
Published: August 2024

Merkel Cell Carcinoma (MCC) is a rare but aggressive form of Neuroendocrine skin cancer that metastasizes to other parts of the body 1 . This cutaneous neuroendocrine tumor primarily affects older individuals, with most cases typically occurring after the age of sixty- five 2 . Five-year overall survival rates range between 48% and 63%. 3 MCC is commonly seen in patients with compromised immune systems, comprising approximately 10% of all MCC cases. Patients with HIV and those who have undergone solid organ transplantation are 13 times and 23.8 times more likely to develop MCC, respectively 4 . Merkel cell polyomavirus (MCPyV) has been found to cause gene mutations leading to this form of skin cancer, while immunosuppression and ultraviolet radiation are also significant risk factors in its development. Nearly one-third of patients are diagnosed initially with loco-regional metastases, such as in- transit metastases or lymph node metastases. MCC can present itself as a cutaneous or subcutaneous nodule that is red, pink, blue, violet, or skin color. (4) MCC has a high propensity for recurrence. 5
Hematologic Complications of Tick Bites and Tick-Borne Illness: A Brief Narrative Review
Authors: Kichloo Asim , El-amir Zain , Ghaleb Amar , Mandal Shobha , Ghantasala Paritharsh
Published: August 2024

Introduction: Tick-borne illnesses are rising in the United States, and tick bites can result in hematologic complications including anemia, thrombocytopenia, pancytopenia, and even life-threatening sequelae like disseminated intravascular coagulation. While case reports and brief reviews exist for specific ticks, there is a lack of review on the known hematologic complications after various tick-borne illnesses. Methodology: This narrative review examined over twenty articles on hematologic complications of tick-borne illnesses published from 2000 onwards. A comprehensive search of electronic databases, including PubMed and Google Scholar, was conducted to identify relevant literature published between 2000 and 2024. Inclusion criteria comprised articles available in English and those describing hematologic consequences of tick-borne illnesses. Exclusion criteria included duplicates, unpublished works, and studies not directly related to the topic. A total of over twenty articles were screened based on title and abstract for eligibility. Discussion: Tick bites can cause various hematologic complications, including anemia, leukopenia, thrombocytopenia, pancytopenia, and disseminated intravascular coagulation by various mechanisms. While it can cause marrow suppression, tick bites can also cause leukocytosis. Clinically, patients can present with profuse bleeding or bruising in some cases or severe diseases like disseminated intravascular coagulation. Workup for these various hematologic pathologies can include complete blood counts and peripheral blood smears. Conclusions: Early identification of hematologic abnormalities related to tick-borne illnesses can be important for clinical management.
Palliative Care in the Pediatric Population
Authors: Rosenscheg Marcelen
Published: August 2024

This is a simple literature review proposed to define and develop guidelines for pediatric palliative care (PPC) based on current studies. Methodology: The study searched for articles on PPC and end-of-life (EoL) care in the pediatric population using the CAPES study platform. Twenty articles were found in this selection. Results: With the continuous advancement of oncological treatments, many studies are conducted on the pediatric population, with particular attention to palliative care. Many of the issues addressed are not just about the treatment itself, but also about understanding the factors involving healthcare professionals, families, and the patient. Conclusion: The approaches to this treatment are still diverse, and referral methods remain flawed; however, the interventions proposed by specialized palliative care groups have proven to be extremely effective
Assessing the Readability in Medical Research Papers
Authors: Bahta Nadir , Fonnes Siv , researcher Postdoktoral , Rosenberg Jacob
Published: August 2024

Background: The objective of this study was to investigate which medical specialties write the most readable articles and categorize what level of education that is required to understand the articles. Methods: This study analyzed articles written by 38 medical specialties, represented by individual reports of 10 articles published after January 2021. The reports consisted of interventional studies from journals specific to each specialty identified by Journal Citation Reports, and a search string was developed and searched in PubMed. Characteristics such as the number of title characters, number of authors, and words in the introduction and discussion paragraphs were analyzed. Readability was measured by Lix score and Flesch Kincaid Grade Level. Subgroup analyses were conducted for popular vs. unpopular specialties, surgery vs. internal medicine vs. other specialties, and specialties with vs. without patient contact. Results: A total of 379 articles were included. The introduction paragraph had a median Lix score of 68 and a Flesch Kincaid Grade Level of 17. The discussion paragraph had a median Lix score of 64 and a Flesch Kincaid Grade Level of 16. Specialties that were popular or with patient contact wrote articles that were more difficult to read than their counterparts, as did internal medicine compared with surgery and other specialties. Conclusion: Readability was estimated as difficult across all medical specialties. Internal medicine wrote papers that were more difficult to read compared with surgery and other specialties. The same was applicable for specialties with patient contact and popular specialties compared with their counterparts. There is a need to make papers more readable across all specialties.
RETROSPECTIVE STUDY OF A SURGICAL PROTOCOL, COMPLICATIONS AND SURVIVAL OF IMPLANTS PLACED IN PATIENTS WITH VON WILLEBRAND DISEASE.
Authors: Gatti Gatti
Published: August 2024

Von Willebrand's disease (VWD), described by Erik von Willebrand, is the most frequent hemorrhagic disorder. Its main symptom is mucosal bleeding. VWD occurs due to a qualitative or quantitative defect of the von Willebrand factor (VWF) molecule and follows an autosomal inheritance pattern. For dental implant placement, the treatment of hemorrhage caused by this disease requires close collaboration between hematologists and oral surgeons. The aim of this study was to evaluate the clinical success rate of dental implants and the incidence of bleeding in patients with VWD when a local surgical protocol was applied, supported by systemic and local hemostatic measures. A retrospective study was performed between January 2018 and December 2023 on patients over 18 years old diagnosed with VWD. All patients had an interview with their hematologist to determine whether they needed a single preoperative dose of DDAVP. A surgical implant protocol was implemented, supported by systemic and local hemostatic measures. Data on age, sex, type of VWD, DDAVP administration, and whether implants were immediate or deferred, flapless or minimally invasive were collected from the medical records. The success rate was evaluated considering absence of pain, mobility and suppuration. Implant stability was measured using a resonance frequency analyzer (Osstell). Data were described by frequencies and percentages with 95% confidence intervals or summary measures, as appropriate. Twenty-eight surgeries were performed, placing 41 implants in 26 patients (23 females and 3 males), with a mean (range) age of 50.5 (23 to 72) years. Among the patients evaluated, 21 had type 1 VWD and one had type 2. No bleeding was recorded. Mean implant stability measured with the Osstell frequency analyzer was 71. Implant stability and success rate in patients with VWD was similar to that reported in other studies on patients without systemic disorders. Systemic and local protocols are essential to avoid complications and ensure successful treatment.
Role of Bcl-2, Apoptotic Index, and Ki-67 Expression in Basal Cell Carcinoma and their Association with Aggressive and Non- Aggressive Histological Phenotypes
Authors: Zuzana Prídavková , Furdová Alena , Lukáš Plank , Peter Žiak , Juraj Halička , Karolína Benca-Kapitánová , Rastislav Vida , Vladimír Bartoš
Published: August 2024

Background The purpose of this paper was to evaluate the association of the Bcl-2 protein, Ki-67 antigen expression and the apoptotic index with biological behaviour of basal cell carcinoma. Methods Combined analysis of retrospective and prospective study of data from two centres over a period of years 2008–2023 on histologically confirmed basal cell carcinoma without any age limitation. Selected prognostic markers related to the aggressive or non-aggressive tumour types were evaluated. Results The study cohort included 66 patients with 68 basal cell carcinomas of the eyelids (n = 68). The median age was 68 years. Resection margins < 2 mm were in 33.9 %, without any connection to recurrence rate (p = 0.076). Average value of Bcl-2 expression in non-aggressive types was 82.65 % (p = 0.000). The value of Ki-67 expression in patients with non-aggressive tumours amounted to 35.49 % (p = 0.068). Non-aggressive tumours most frequently exhibited the apoptotic index of Grade I (p = 0.535). No Grade III case was observed in the aggressive types. In two cases, the orbital exenteration was carried out (0.03 %). In one case was administered biological therapy. HDR brachytherapy was applied in 6 cases. A recurrence of the disease was observed in 4 cases (0.06 %). Conclusion New information on cancer biomarkers in basal cell carcinoma contribute to choosing a correct therapy with achieving good aesthetic results and a good survival rate. Key words: Bcl-2 protein, Ki-67 antigen, apoptotic index, basal cell carcinoma, onco-ophthalmology Keywords: Bcl-2 protein, Ki-67 antigen, apoptotic index, basal cell carcinoma, onco-ophthalmology
The Impact of Dating Violence and Manipulation on Teenagers Mental Health
Authors: Acar Ayşe
Published: August 2024

Dating violence encompasses physical, sexual, emotional, and digital abuse, profoundly affecting the physical and psychological well-being of young individuals. The prevalence of dating violence is comparable to marital violence, with women being the primary victims, although violence against men is also notable. Key risk factors include exposure to familial violence, cultural gender roles, peer influence, and substance use. The consequences of dating violence are severe, leading to depression, anxiety, low self-esteem, self-harm, suicidal ideation, and post-traumatic stress disorder (PTSD). The aim is to mitigate the effects of victimization resulting from dating violence and manipulation, increasingly observed among high school students and young adults, through effective intervention programs. These programs are designed to target the specified age group, promote healthy relationship behaviors, and provide primary and secondary prevention and support to victims. Effective intervention requires both primary and secondary prevention programs targeting high school students and young adults, promoting healthy relationship behaviors and providing support for victims. Comprehensive education, awareness programs, and strong support systems from family and community are crucial in mitigating the effects of dating violence and fostering safer relationships. Despite ongoing publications on the subject, the inadequacy of current reports highlights the need for more frequent and rigorous research in this area. This review underscores the need for increased resources and tailored strategies to address and prevent dating violence, taking into account gender differences in attitudes and perceptions.
Current Approach and Treatment of Myocardial Infarction Associated with Cocaine Use
Authors: Miranda Paula , Veas Nicolas
Published: August 2024

Introduction: The global crisis of illicit substance consumption, particularly cocaine, extends beyond individual users, impacting social, cultural, and institutional levels. Cocaine use is associated with a myriad of illicit activities and significantly affects public health, especially in underdeveloped countries. This study examines the cardiovascular risks linked to cocaine use, focusing on conditions such as chest pain and acute myocardial infarction. Methodology: A comprehensive review of the literature was conducted to explore the epidemiology, pathophysiology, and treatment strategies for cocaine-associated cardiovascular events. Data on cocaine use prevalence and related cardiovascular incidents were analyzed, alongside mechanisms of cocaine-induced myocardial damage and treatment protocols. Results: Cocaine use has increased, particularly among young adults, leading to higher prevalence rates of cardiovascular events, including acute myocardial infarction. Cocaine induces vasoconstriction, arrhythmias, and oxidative stress, contributing to myocardial ischemia and infarction. The literature reveals a significant incidence of severe coronary atherosclerosis and multivessel disease among young cocaine users experiencing acute myocardial infarction. Immediate intervention strategies, including dual antiplatelet therapy and percutaneous coronary intervention, are essential but must be tailored to the unique challenges posed by cocaine's effects. Conclusions: Cocaine elevates the risk of severe cardiovascular events, necessitating targeted prevention and treatment strategies. The management of acute myocardial infarction in cocaine users requires a personalized approach, considering the drug's complex impact on cardiovascular health. Preventive measures and early intervention are crucial to mitigating the heightened risk of myocardial infarction and other cardiac events in this population.
Gene therapy of neurological and non-neurological diseases using herpes simplex virus vectors
Authors: Epstein Alberto
Published: August 2024

Two main types of vectors can be derived from herpes simplex type 1 (HSV-1), non-replicative vectors and replication-selective oncolytic vectors. The main goal of this review is to describe the key features that make non-replicative HSV-1 vectors (nrHSV-1) extremely appealing for gene therapy of peripheral and central nerve diseases. This includes the many outstanding adaptations that this human neurotropic virus has developed to safely infect, persist, and perform long-term gene expression in neurons, their very large transgene cargo capacity, unique amongst nuclear mammalian viruses, and the very important fact that they can be readministered several times due to the extremely low levels of immunological responses they elicit. This review also describes several preclinical studies as well as the clinical trials that have been developed or are ongoing with nrHSV-1, including gene therapy of cancer-related intractable pain and of recessive dystrophic epidermolysis bullosa (RDEB), which has been recently approved by the FDA. In the second part of this review, we compare side-by-side, the advantages and the drawbacks of nrHSV-1 and adeno-associated vectors (AAV), the most currently used gene therapy vector. Lastly, we will very briefly describe oncolytic vectors and a second type of nrHSV-1 vectors known as amplicons.
Editorial 13-1
Authors: Cortés-García Cristian Alejandro , Moreno Ángel Mónica Tatiana
Published: August 2024

Editorial 13-1
Educación artística, un camino hacia la transformación educativa en contextos de básica primaria. Revisión sistemática
Authors: Cantor Galindo Olga Esperanza , Vásquez Rodríguez Karol Marcela , Aparicio Gervás Jesús María
Published: August 2024

Historically, Art Education has been historically positioned as a device to enhance abilities, skills and human habits from the first years of life. From this perspective, the main purpose of this article is to illustrate the product of the systematic review carried out between March 2021 and January 2023, whose objective was the exploration of studies to identify and analyze the relationship between arts education and education for life in elementary school contexts. In this sense, the research was carried out in the Scopus, Web of science, Dialnet, Redalyc and Scielo databases. This is a descriptive study, duly registered in the checklist based on the PRISMA 2020 statement. Its contents detail relevant findings extracted from a rigorous final selection of 12 publications whose review leaves as a general conclusion the evident need to generate and strengthen strategies in which practices related to arts education are privileged as a path towards the strengthening of life skills, especially in primary education contexts, since this is a favorable stage for exploration, the strengthening of habits, communicative processes, creativity, logical thinking, emotional management, among other aspects of human formation in the individual and collective. In short, it is possible to evidence a panorama that places arts education as a device to generate forceful transformations in the educational, social and cultural spheres of humanity.
Bilateral descendens vago-hypoglossi of ansa cervicalis
Authors: Sakthivel Sulochana , Banu Jahira
Published: August 2024

Ansa cervicalis, a nerve loop formed by descendens hypoglossi contributed by C1 spinal nerve and descendens cervicalis, by C2 and C3 spinal nerves, innervates the infrahyoid muscles. An unusual formation of ansa cervicalis was noted in a 60-year-old female cadaver, bilaterally. On the left side, fibres from the hypoglossal and vagus nerves contributed to the formation of descendens vago-hypoglossi. Fibers from the ventral rami of C2 and C3 spinal segments ran downwards separately as a double descendens cervicalis and united at the loop formation. A similar variation was observed on the right side with a normal descendens cervicalis. The vago-hypoglossal anastomosis was longer on the left side than on the right. The neurofascial band between the vagus and hypoglossal nerve may lead to internal carotid artery stenosis. Ansa cervicalis is surgically significant, especially during laryngeal reinnervation procedures for recurrent laryngeal nerve palsy. The variation in the formation and course of the ansa cervicalis may significantly alter and complicate interventional procedures like neurorrhaphy, neck dissection or anterior cervical spinal approach.
Fatal transfer of fate– A case report
Authors: Ramalingam S  , Narayanan S
Published: August 2024

A spinal cord injury is caused by damage to any part of the spinal cord or entire spinal cord. It also includes damage to nerves at the end of the spinal cord, known as the cauda equina. The spinal cord helps in transmitting signals between the brain and the rest of the body. A spinal cord injury often causes permanent or temporary changes in strength, feeling, and other bodily functions. People may also experience mental, emotional, and social side effects. In the meantime, treatment and rehabilitation allow many people with spinal cord injuries to lead productive, independent lives. In many occupations, employees are required to work at heights. They may have to work with platforms, scaffolds, or ladders to complete a job-related task. The main risk these employees face is that they can fall to the ground because of inadequate fall protection. Employers need to take proper steps to protect their employees who work at heights to help avoid unfortunate, serious accidents. Here we discuss a 24-year-old male working on a construction site as a semi-skilled worker, while working on the ground floor sustained injury after the fall of another male person from a height landed on him. The person who fell from height survived and the person who was working on the ground succumbed to death.
Olfactory neuroblastoma: A rare case report
Authors: Goyal Anjali , Jhala Kajalba H , Damor Kinjal , Upadhyaya Prahari
Published: August 2024

Olfactory neuroblastoma (ONB) is an uncommon malignant tumor of the sinonasal tract that arises from the olfactory neuroepithelium and exhibits neuroblastic differentiation. Here, we present the case of a 48-year-old woman who complained of epistaxis for 4 months, nasal obstruction, and headaches for 6 months. Upon examination, a mass was identified in the left nasal cavity and confirmed by radiological imaging. Surgical excision was performed, and the tissue specimen was sent for histopathological analysis, which confirmed the diagnosis of olfactory neuroblastoma. Immunohistochemical markers revealed focal positivity for chromogranin, synaptophysin, AE1/AE3, CK7, with a high Ki-67 index (60-70%), and negativity for S-100.
OBTENCIÓN Y CARACTERIZACIÓN DE UN NOVEL ALERGENO MEDIANTE LA TECNOLOGÍA DEL DNA RECOMBINANTE
Authors: Puerta Leonardo
Published: August 2024

Los alergenos como agentes inductores de las alergias han motivado su obtención y caracteriza­ción como vía para el conocimiento de sus propiedades y de un mejor manejo de las alergias. Mediante la tecnología del DNA recombinante un nuevo alergeno, (Blo t 13) fue identificado y agregado a la lista de los alergenos caracterizados de la Organización Mundial de la Salud. Este trabajo muestra la vía de obtención de dicho alergeno recombinante, sus características estructurales y la determinación de su actividad de unión a ácidos grasos. El alergeno fue producido en dos sistemas de expresión; la bacteria Eschericia coli y la levadura Pichia pastoris. Se analizan las propiedades alergénicas y la actividad biológica de la proteína recombinante obtenida en los dos sistemas.
EN BÚSQUEDA DEL HÁBITAT DE CRYPTOCOCCUS NEOFORMANS VARO GATTII EN COLOMBIA
Authors: Castañeda Elizabeth
Published: August 2024

Se analizan los estudios de tipo diagnóstico e investigativo que sobre el hongo patógeno Cryptococcus neoformans var. neoformans y var. gattii se han llevado a cabo en el laboratorio de micología del INS. Se destaca la frecuencia de una variedad de este microorganismo, la var. gattii, en ciertas regiones del país y la severidad de la patología por ella producida. Igualmente, se descri­ben los pasos seguidos para demostrar su hábitat, su relación con los almendros (Terminalia catappa), su capacidad de desarrollo en plántulas y las posibles conexiones entre la planta, C. neoformans y el humano.
BOMBACACEAE NEOTROPICAE NOVAE VEL MINUS COGNITAE I. NOVEDADES TAXONÓMICAS Y COROLÓGICAS EN MATISIA, QUARARIBEA Y SPIROTHECA.
Authors: Fernández-Alonso José Luis
Published: August 2024

Como parte de los trabajos que actualmente se adelantan en la familia Bombacaceae, y como primera entrega de la serie <>, se describen algunas novedades taxonómicas en los géneros: Matisia Humb. & Bonpl. (5 secciones y 4 especies), Quararibea Aubl. (una especie) y Spirotheca Ulbr. (dos especies) y se tratan novedades corológicas en el género Matisia.