bluuebunny/crossref_metadata_2025 huggingface dataset:
Based on the proteomics method to explore the relative differential protein expression of carbon tetrachloride-induced acute liver injury in mice
Authors: Li Weihua , Lei Yanli , Jin Xueqin , Wang Zhisheng , Lu Xiaoli , Yang Li , Wu Jing
Published: July 2022

Background
CCL4 as a chemical inducer,which can induce multiple organ damage, especially acute liver injury,but the related mechanism of its damage has not been systematically reported.
Methods
In this study, we exposed BALB/c mice for 8 weeks, and found significant inflammatory damage and dysfunction to the liver in blood biochemical indicators and histopathological observations. Using tandem mass tag (TMT) marker proteomic analysis identified 395 proteins that were significantly altered in the liver,as indicated by Gene Ontology (GO) annotation,KEGG pathway and protein-protein interaction (PPI) network analysis more significant proteins.
Results
We found that distinctly enriched differential proteins play important roles in gene expressionin terms of protein expression difference multiples, biomarker application and participation in classical signal pathway (JAK-STAT signaling pathway,PI3K-Akt signaling pathway,Rap1 signaling pathway,PPAR signaling pathway,GnRH signaling pathway,AGE-RAGE signaling pathway). There are significant enrichment for differential proteins in classical signal pathway, and the enrichment was relatively high. These pathways mainly included in the body's immunity,cell division,apoptosis and autophagy, inflammation and tumor formation,and also mediate the expression level of related proteins in MAPK/ERK signaling pathway,NF-КB signaling pathway and TGF-β signaling pathway.
Conclusions
Using proteomics methods to explore the possible pathways of CCl4 inducing acute liver injury. On the one hand, Multi-directional and multi-target exploration will reveal the toxic mechanism of chemical toxins on liver injury in a deeper level, and on the other hand, it will enrich the relevant research database.At the same time, it also provides a new direction and basis for the further development of liver-protecting targeted drugs.
Strain tuning of negative capacitance in ferroelectric KNbO3 thin films
Authors: Luo Yongjian , Chen Deyang , Wang Zhen , Chen Yu , Qin minghui , Fan Zhen , Zeng Min , Zhou Guofu , Lu Xubing , Gao Xingsen , Liu Jun-Ming
Published: July 2022

Ferroelectrics with negative capacitance effect can amplify the gate voltage in field-effect transistors to achieve low power operation beyond the limits of the Boltzmann's Tyranny. The reduction of power consumption depends on the capacitance matching between the ferroelectric layer and gate dielectrics, which can be well controlled by adjusting the negative capacitance effect in the ferroelectrics. However, it is a great challenge to experimentally tune the negative capacitance effect. Here, the observation of tunable negative capacitance effect in ferroelectric KNbO3 through strain engineering is demonstrated. The magnitude of the voltage reduction and negative slope in polarization-electric field (P-E) curves as the symbol of negative capacitance effect can be controlled by imposing various epitaxial compressive strain. The expansion of negative curvature region in polarization-energy landscape under compressive strain is responsible for the tunable negative capacitance. Our work paves the way for fabricating low power devices and further reducing energy consumption in electronics.
Lower leg blood pressure decreases while calf external pressure increases with the angulation of the Trendelenburg position in the lithotomy position with calf- and foot-supported leg holders
Authors: Mizuno Ju , Iijima Satomi , Takahashi Toru
Published: July 2022

Objective
Patients who underwent lower abdominopelvic surgeries in the lithotomy position (LP) and the Trendelenburg position (TP) with the leg holder are at risk of developing well leg compartment syndrome (WLCS). However, contributing factors related to the LP with TP associated with WLCS are unknown. This study aimed to investigate the associations between external pressure at the calf in the LPs at different angulations of the TP and physiological characteristics.
Methods
Eighty-four university students (age, 21.7 ± 0.9; 42 men and 42 women) voluntarily participated in the study. The awake participants were placed in the LPs using the calf- and foot-supported leg holder at 0° (horizontal level), 5°, 10°, and 20° head-down tilts by moving the electric operating table. The peak contact pressure (pCP) was measured at the calf as a representative external pressure using the pressure distribution measurement system BIG-MAT®.
Results
Lower leg blood pressure significantly decreased with TP angulation, while calf pCP significantly increased with it at 0°, 5°, 10°, and 20° head-down tilts (39.4 ± 15.2, 46.5 ± 17.7, 47.2 ± 16.9, and 50.3 ± 17.6 mmHg, respectively). The calf pCP with a 10° head-down tilt was correlated positively with the calf total force (P < 0.001) and negatively with the calf contact area (P < 0.001).
Conclusion
Blood hypoperfusion due to low lower leg blood pressure secondary to lower leg elevation and head-down tilt, and high calf external pressure due to direct external compression from the leg holder where it is loaded may contribute to WLCS.
Assessment of the land use classification surrounding a dam in the semi arid of Pernamuco/Brazil from OLI, MUX images and WorldCover data
Authors: Júnior Juarez Antônio da Silva , Pacheco Admilson da Penha
Published: July 2022

Detecting changes in land cover helps policymakers to understand the dynamics of environmental changes to ensure sustainable development in the Caatinga Biome. Thus, the identification of spatial features by Remote Sensing emerged as an important research aspect and, therefore, an adequate and accurate methodology for land cover mapping was necessary. In this study, Landsat-8 and CBERS-4 satellite data captured by the Operational Land Instrument (OLI) and the Regular Multispectral Camera (MUX) were used for classification and accuracy analysis for six land cover classes around the dam ‘Barra do Juá’, located in the semi-arid region of Pernambuco state. Recent high resolution images from the European program WorldCover were used as spatial and thematic reference images. The approach developed provided land cover maps for each dataset. After the comparative analysis with the reference product, an accuracy of the producer and average user of 62.44% and 71.74% for MUX and 60.88% and 62.38% for OLI were obtained, respectively. Spatial and spectral characteristics of the images were the main causes of the variability found in the thematic accuracy coefficients. The results obtained showed that the CBERS-4 MUX presented more satisfactory land cover maps than the Landsat-8 OLI data. However, for the classes of natural vegetation, OLI presented better results than MUX.
Forensic analysis of novel SARS2r-CoV identified in game animal datasets in China shows evolutionary relationship to Pangolin GX CoV clade and apparent genetic experimentation
Authors: Jones Adrian , Massey Steven E , Zhang Daoyu , Deigin Yuri , Quay Steven C.
Published: July 2022

Pangolins are the only animals other than bats proposed to have been infected with SARS-CoV-2 related coronaviruses (SARS2r-CoVs) prior to the COVID-19 pandemic. Here we examine the novel SARS2r-CoV we previously identified in game animal metatranscriptomic datasets sequenced by He et al. (2022) and find that sections of the partial genome phylogenetically group with Guangxi (GX) pangolin CoVs (GX PCoVs) while the full RdRp sequence groups with bat-SL-CoVZC45. While the novel SARS2r-CoV is found in 6 pangolin datasets, the same CoV is also found in 10 additional NGS datasets from 5 separate mammalian species and is likely related to contamination by a laboratory researched virus. We find that NGS datasets containing the novel SARS2r-CoV are contaminated with significant Homo sapiens genetic material, and numerous viruses not associated with the host animals sampled. We further identify the dominant human haplogroup of the contaminating H.sapiens genetic material to be F1c1a1, which is of East Asian provenance. The association of this novel CoV with both bat CoV and the Guangxi pangolin CoV (GX PCoV) clades is an important step towards identifying the origin of the GX PCoVs.
A closer look at Self Esteem and Perceived Social Support: Their role in Depression among Women with Chronic Illnesses
Authors: Bano Nasreen , Shahzad Salman , Ahmad Shafaq
Published: July 2022

Chronic illnesses not only bring physical strains but also affect one's psychological health. Long-term treatments and variations in severity demand psychological resources to cope up with these illnesses. Cancer and heart diseases are among those illnesses which are quite prevalent and tax one’s resources to fight with illnesses. A cross sectional study design was used to carry out this study which aims to find the predictive association of depression with self-esteem and perceived social support among women with chronic illness (breast cancer and angina). A sample of 102 women diagnosed with breast cancer (51) and Angina (51) with the age ranges between 30-60 years (Mean age = 47.6, SD=10.68), were taken. They were recruited from different hospitals including Sindh Government Hospital, Dar-ul-Sukoon and Dow university Hospital Karachi, Pakistan using purposive sampling technique. Patients’ Health Questionaire-9, Rosenberg Self-Esteem, and Multidimensional Perceived Social Support was administered. Findings show that self-esteem has contributed to lowering depression in women diagnosed with cardiac illness (Angina) as well as cancer (breast Cancer).Perceived social support has a significant effect on depression in women with cardiac illness (Angina) however it has a non-significant contribution in the reduction of depression in women with cancer (breast cancer).
Gravitational folding of surface tension regions originates bio quantum path duality that quantizes Newtonian rigid inertia into parameter trigonometric inversion topological bio inertia
Authors: Lai Yi Yu
Published: July 2022

Universal interaction reference systems in nature can’t avoid elastic inversion(memory). Newton established the parameter quantity-driving rigid reference system with zero system inversion. Bio-systems fall to another extremity that can only utilize inversion energy with almost zero rigidness. We define inversion energy as parameter-against-gravity-internal-fluctuation, write down modifications of Newtonian three Laws as, first law: 𝑑𝑑𝑥cosx =−𝑠𝑖𝑛𝑥, 𝑑𝑑𝑥sinx = 𝑐𝑜𝑠𝑥; second law: 𝐹⃗=𝑚∙𝑎⃗ + |𝑚𝑔⃗∫𝑡𝑔𝜃⋅𝑑𝜃 ⟩↿⇂; third law: Wavelength = 2𝑛L, frequency = n𝑓0 . The Schrödinger equation has only quantized energy but still hasn’t quantized time thus inducing quantum collapse. We then conjugate inversion energy with quantizing time which composes of event inversion superposition to establish entropy-control lifespan for bio-systems. Originated from the gravitational folding of surface tension regions, bio quantum path duality fluctuation scales as macrocosmic elastic quantum ranges from a codon to the spinal size drives life evolution. The driving dynamics of biological functions including consciousness revive from the bio quantum path duality that modulates by the three modified laws.
PROBLEMATIC ASPECTS OF ACCOUNTING REFLECTION OF PROVISIONS FOR FUTURE EXPENSES AND PAYMENTS
Authors: Serpeninova Y. , Gritsenko L , Oleksich Zh. , Panchenko A. , Tovstukha K.
Published: July 2022

The relevance of this research is indisputable because a significant number of issues regarding the accounting of future expenses and payments (mandatory creation, different approaches to classification, imperfect regulations, complexity of calculating the size and order of accounting) are debatable and require detailed study. as it is one of the effective ways to prevent risks that may arise in the course of economic activity of any enterprise, as well as the formation of collateral improves financial stability of the enterprise, as it reduces the risk of significant losses and profitability in some periods.
The article systematizes and explores the main problematic aspects of accounting for future expenses and payments, in particular due to the presence of many uncoordinated issues of collateral: mandatory creation, different approaches to classification, imperfect regulations, complexity of calculating the size and order of reflection in accounting. Possible ways to solve these problems by researching and further developing the issue of collateral classification are suggested. By separating different types of collateral, unifying regulations, detailing the existing chart of accounts (by introducing new sub-accounts for future expenditures and payments by type of collateral in the Chart of Accounts, the lack of detail which, in turn, does not allow management to meet existing needs in information), development and improvement of primary documents (taking into account the peculiarities of their activities and the feasibility of forming appropriate collateral), as well as to avoid distortion of financial statements, reflect the reduction (write-off) of collateral only in the amount accrued in the reporting year, and if the amount of reduction (write-off) of collateral exceeds such amounts, the amount of excess should be recorded on the debit of the collateral account and the credit of the account of retained earnings (uncovered loss).
ECONOMIC EFFICIENCY EVALUATION OF WIND ENERGY INSTALLATION INTRODUCTION AT AN INDUSTRIAL ENTERPRISE
Authors: Karpishchenko O. , Horbul A.
Published: July 2022

In the conditions of permanent and rapid world energy prices growth, the electricity generation using renewable energy sources (RES) introduction is becoming increasingly important. Given Ukraine's aspirations to join the European Community, incentives for electricity generation through RES have been introduced at the state level. The main tool of electricity producers’ stimulation is the "green tariff". Its size significantly exceeds the cost of purchasing electricity from traditional generation sources, which contributes to the development of this area of energy.
At the same time, insufficient attention is paid to the own electricity generation introduction based on RES by industrial enterprises, which has become especially relevant given the rapid rise in natural gas prices in 2021 and the corresponding increase in prices for other energy sources.
The goal of this article is to study the feasibility of a wind farm introducing to meet industrial enterprises electricity needs.
The objectives of the study are to analyze the wind energy using advantages and disadvantages and practical aspects of such equipment use, assessing the possibility and feasibility of using it in an industrial enterprise under the "green" tariff. The economic aspects of such an innovation are also considered.
The required electrical power of the furniture production enterprise needs have been calculated. The economic substantiation of expediency of wind power plant for full maintenance needs in the electric power is carried out. Calculations of the required power plant capacity, wind speed, payback period of investments have been made.
The results of the study can be used to decide alternative power sources introduction in similar enterprises. And also can be taken as the plan of electrification basis for enterprises of other branches.
Further research is planned to consider to options for the solar power plants, hybrids of solar and wind power plants introduction to meet the individual industrial enterprise’s needs, as well as batteries to store excess energy and equalize the generating capacity utilization in conditions of daily load fluctuations.
ENVIRONMENTAL MANAGEMENT IN THE OIL REFINING SECTOR: BIBLIOMETRIC ANALYSIS
Authors: Maksakova K. , Kostyuchenko N.
Published: July 2022

The article, based on bibliometric analysis of articles published in journals included in the database of Web of Science and Scopus, identifies promising areas of research on topics related to the organizational principles of environmental management of refineries. The sample consisted of 2,296 articles published in journals indexed in Web of Science and Scopus databases from 2019 to 2021. The author used the basic technique of bibliometric analysis using VOSviewer software based on publications obtained from the Dimensions database.
In the process of research: selection of the most influential publications by the number of citations, analysis of the activity of publications by country, analysis of the use of keywords and terms, construction of a bibliographic map of research trends, as well as construction of industry affiliation of scientific publications on a particular topic.
The article includes cases from around the world and from a number of leading international oil and refining companies.
The study reveals the most pressing issues related to the environmental management of refineries. The result of the research is a map that reflects the existing relationships between the keywords of the most cited publications in the field of environmental management of refineries. In general, bibliometric analysis is one of the effective methods that allows you to get an idea of the problems facing researchers and identify key areas for research.
The results of the study can be used by scientists to identify trends in the field of environmental management of refineries, as well as the actual refineries to make promising management decisions in the process of their activities.
The research of political information in the regional media of Ukraine
Authors: Kosiuk Oksana
Published: July 2022

The article testifies to the degree of bias of the rating regional Internet media of the Volyn region such as «VolynPost» and «Volynski Novyny» in terms of coverage of events in the political life of the Ukrainian and international levels: the activities of deputies, the war in Donbass, international terrorism, The Second Karabakh War, the explosion in Beirut, The War in Afghanistan and the like. It was found that national events are covered through the prism of the ideology by the political party of the owner of the media, with elements of using black PR technologies about the activities of opposition communities. International information, as a rule, is reprinted from other media with reference to highquality and balanced expertise. Despite the official ranking data, «Volynski Novyny» agency publishes political information better.
Self-branding of a modern media specialist in the structure of digital reality
Authors: Hyrina Tetiana , Khliust Vladyslava
Published: July 2022

The article aims to identify the potential and prospects for the implementation of media in the digital dimension of technologies for building a personal professional brand, as a guarantee of accumulation of
its own audience in social networks. The concepts of self-branding in journalism are analyzed, the method of sociological survey (questionnaire) clarifies the expectations of producers of media content for users and identifies the optimal vectors for their interaction in the structure of digital reality.
Longitudinal Z-boson polarization and the Higgs boson production cross-section
Authors: Amoroso Simone
Published: July 2022

We present a study of the LHC (and HL-LHC) potential towards a
precise determination of the gluon parton distribution function of the
proton at intermediate Bjorken-xx
from measurements of Drell-Yan production. To this extent, we exploit a
clean and theoretically well predicted observable: the Drell-Yan lepton
angular coefficient A_0A0,
associated with the longitudinal polarization of the Z boson. Through a
detailed numerical analysis using the open-source xFitter platform, we
illustrate how this observable can provide significant sensitivity over
current determinations of the gluon PDF, and a reduction in the PDF
uncertainty on the Higgs boson production cross-section by a factor of
over 50%.
Next generation proton PDFs with deuteron and nuclear uncertainties
Authors: Pearson Rosalyn , Ball Richard , Nocera Emanuele
Published: July 2022

As data become more precise, estimating theoretical uncertainties in
global PDF determinations is likely to become increasingly necessary
to obtain correspondingly precise PDFs. Here we present a soon-to-be-released next
generation of global proton PDFs (NNPDF4.0) that include theoretical
uncertainties due to the use of heavy nuclear and
deuteron data in the fit. We estimate these uncertainties by comparing
the values of the
nuclear observables computed with the nuclear PDFs against those
computed with proton PDFs. For heavy nuclear PDFs we use the
nuclear nNNPDF2.0 set, while for deuteron PDFs we develop an iterative
procedure to determine proton and deuteron PDFs simultaneously, each
including the uncertainties in the other. Accounting for nuclear
uncertainties resolves some of the tensions in the global fit of the
proton PDFs, especially those between the nuclear data and the
extended LHC data set used in NNPDF4.0.
Recent Studies of Exotic Hadrons at the LHCb Experiment
Authors: Robertson Gary
Published: July 2022

Recent results on studies of exotic hadrons at the LHCb experiment
are summarised. These are the observation of new resonances decaying to
J/\psi K^+J/ψK+
and J/\psi\phiJ/ψϕ,
evidence of a J/\psi\LambdaJ/ψΛ
structure and observation of excited \Xi^-Ξ−
states in the \Xi_b^-\to J/\psi\Lambda K^-Ξb−→J/ψΛK−
decay and the study of B_s^0\to J/\psi\pi^+\pi^-K^+K^-Bs0→J/ψπ+π−K+K−
decays.
Measurements of W and Z boson production in ATLAS
Authors: Wu Zhibo
Published: July 2022

Precision measurements of the production cross-sections of W and Z
boson at LHC provide important tests of perturbative QCD and information
about the parton distribution functions for quarks within the proton. We
present measurements of cross sections for inclusive
W^+W+,
W^{-}W−
and Z boson production using data collected by the ATLAS experiment at a
center-of-mass energy of \sqrt{s}s=2.76 TeV.
Measurement of the transverse momentum distribution of Z boson at
\sqrt{s}s=13 TeV
is also presented. The measurements are corrected for detector effects
and compared with state-of-the-art theoretical calculations.
Silver Nanoparticles Biosynthesis Using Mangosteen (Garcinia Mangostana L.) Rind Extract For Environmentally Friendly Liquid Disinfectant Active Ingredients
Authors:   Department of Chemistry, Faculty of Mathematic and Natural Science, Halu Oleo University, Haris Watoni Abdul , Ode Ahmad Nur Ramadhan La ,   Department of Chemistry, Faculty of Mathematic and Natural Science, Halu Oleo University, Daffa Rahmatullah Muhammad ,   Department of Chemistry, Faculty of Mathematic and Natural Science, Halu Oleo University, Ike Dwiyanti Kalpen Bunga Angelina ,   Department of Chemistry, Faculty of Mathematic and Natural Science, Halu Oleo University, Supardi Supardi ,   Department of Chemistry, Faculty of Mathematic and Natural Science, Halu Oleo University
Published: July 2022

Disinfectant is one of the materials that can be used to inactivate pathogenic microorganisms, but most of the disinfectants used in the community are disinfectants made from synthetic chemicals that are harmful to the environment. The purpose of this study was to synthesize and evaluate the antimicrobial activity of silver (Ag) nanoparticles-mangosteen rind extract as an active ingredient in an environmentally friendly disinfectant formula. The synthesis process of silver nanoparticles was carried out by adding a bioreductant of mangosteen rind extract into a 0.01 M AgNO3 solution precursor with a variation of the precursor : bioreductor volume ratio of 1:1, 1:2, 1:3, 1:4, 1:5, and 1:6, respectively. The results of the analysis with UV-Vis spectroscopy showed that the silver nanoparticles of mangosteen rind extract had good stability. The decrease in the absorption peak in the FTIR spectrum at a wave number of 3390.86 cm-1 indicates the contribution of the –OH group in the bioreductant compound in the reduction process of silver nanoparticles. PSA analysis and digital microscopy showed that the diameter of the synthesized silver nanoparticles with a volume ratio of bioreductor : precursor 1:1 was 82.33 nm. The antimicrobial activity test showed that the active ingredient mixture of silver-mangosteen rind extract with a composition of 1:1 had the best activity in deactivating of gram-positive Staphylococcus aureus and gram-negative Escherichia coli bacteria. The results of this study indicate that the mixture also can be used as active ingredients for environmentally friendly liquid disinfectants.
Detecção de quebras em diálogos humano-computador
Authors: De Andrade Leonardo , Paraboni Ivandré
Published: July 2022

Com o crescimento constante no uso de tecnologias de relacionamento com o consumidor na Internet, os sistemas de chatbot se tornaram onipresentes no processamento de linguagem natural (PLN) e áreas relacionadas. Apesar dos avanços significativos nos últimos anos, no entanto, sistemas desse tipo nem sempre fornecem resultados plausíveis e consistentes, em muitos casos levando a uma quebra no diálogo. Assim, há grande interesse em investigar as circunstâncias nas quais erros deste tipo são produzidos e, quando possível, aprimorar o projeto destes sistemas de modo a minimizar tais erros. Com base nestas observações, neste trabalho abordamos a questão da detecção automática de quebras em diálogos humano-computador apresentando três modelos que levam em consideração o histórico de diálogo para decidir quando ele possui maior probabilidade de culminar em uma quebra. Os modelos propostos exploram uma variedade de métodos de PLN recentes, e são avaliados tanto com base em um conjunto de dados de diálogos reais em português entre usuários humanos e sistemas de chatbot desenvolvido especificamente para este fim, como também utilizando benchmarks publicamente disponíveis para o idioma inglês.
Análise Semântica com base em AMR para o Português
Authors: Torres Anchiêta Rafael , Salgueiro Pardo Thiago Alexandre
Published: July 2022

A Representação Abstrata de Significado (no inglês, Abstract Meaning Representation ---AMR) é um formalismo semântico projetado para capturar o significado de uma sentença, representando-a como um grafo direcionado acíclico de única raiz com nós rotulados (conceitos) e arestas (relações) entre os nós. Essa representação tem recebido bastante atenção da comunidade de Processamento de Língua Natural, pois muitos autores têm proposto vários modelos de analise semântica para produzir grafos AMR a partir de uma sentença, visando melhorar o entendimento da língua natural. Entretanto, a maioria desses modelos focam no inglês devido a falta de grandes corpora anotados para outras línguas, deixando uma lacuna entre o inglês e outros idiomas. A fim de superar esse problema, neste artigo, é realizada uma análise detalhada de vários analisadores AMR, adaptando três modelos diferentes para o português e propondo melhorias. Além disso, estendeu-se um analisador baseado em regras desenvolvido previamente para o português. Esses modelos foram avaliados sobre um corpus anotado para o português. Por fim, realizou-se uma análise detalhada de erros com o objetivo de identificar os maiores desafios para análise no português e obter insights que possam ajudar pesquisas futuras nesta área.
De eeuwige vragen van de filosofie
Authors: Streumer Bart
Published: July 2022

Oratie uitgesproken door prof. dr. Bart Streumer op 3 juni 2022 bij de aanvaarding van het ambt van hoogleraar Ethiek aan de Faculteit Wijsbegeerte Rijksuniversiteit Groningen Filosofen stellen al eeuwenlang dezelfde vragen zonder dat ze het eens worden over de antwoorden. Wat is waarheid? Wat is kennis? Wat is de relatie tussen onze gedachten en de werkelijkheid? Wat zijn normen? En ga zo maar door. Hoe komt het dat filosofen het niet eens worden over de antwoorden op deze vragen? Misschien doordat de vragen te abstract geformuleerd zijn, of doordat ze verborgen aannames bevatten die niet kloppen, of doordat we ze alleen maar stellen omdat we in de war worden gebracht door onze taal. In zijn oratie zal Bart Streumer een andere mogelijkheid onderzoeken: dat er wel juiste antwoorden zijn op deze vragen, maar dat we die antwoorden niet kunnen geloven. Dat zou kunnen verklaren waarom filosofen het niet eens worden over wat de juiste antwoorden zijn. Met alle antwoorden die we kunnen geloven is iets mis, terwijl we het enige antwoord waarmee niets mis is niet kunnen geloven. Streumer zal vooral ingaan op vragen waarop we het juiste antwoord wellicht niet kunnen geloven om een specifieke reden: omdat als we proberen het juiste antwoord te geloven, we daardoor automatisch een ander antwoord op dezelfde vraag gaan geloven waarmee iets mis is. Hij past dit toe op de theorie van George Berkeley, die het bestaan van materie ontkende en beargumenteerde dat alleen denkers en hun gedachten bestaan, en op de theorie van Simon Blackburn, die beargumenteert dat uitspraken over de objectiviteit van normen uitingen van gevoelens zijn. De oratie is een pleidooi om te blijven proberen de eeuwige vragen van de filosofie te beantwoorden, ook al worden we het misschien nooit eens over de antwoorden.
Prediction injury of the central nervous system in the neonatal period in preterm newborns
Authors: Pavlinova E. B. , Gubich A. A. , Savchenko O. A.
Published: July 2022

Objective: to develop a system for predicting the probability of developing damage of the central nervoussystem (CNS) in the neonatal period in children who was born prematurely. Materials and methods: the main group of the study is premature newborns with gestational age (GA) less than 36 weeks inclusive (n = 60), the control group – fullterm newborns (n = 35). In the process of dynamic observation, the main group was divided into subgroups depending on the diagnosed CNS injury in the neonatal period, according to the neurosonography (intraventricular hemorrhages (IVH), periventricular leukomalacia (PVL): subgroup 1 (prematurity babies with CNS injury) – 25 people, subgroup 2 (premature babies without CNS injury) – 35 people. we estimated clinical and anamnestic, laboratory and instrumental data of children at birth and in dynamics, indicators of antioxidant protection (manganese-containing superoxide dismutase (Mn-SOD), copper, zinc-containing superoxide dismutase (Cu, Zn-SOD), reduced glutathione (GSH), oxidized glutathione (GSSG), total antioxidant capacity of blood (TAS/TAC), oxidative stress (TOS/TOC), 4 polymorphisms of Mn-SOD gene. Results: we designed two prognostic models which can determine the probability of developing IVH and PVL in the neonatal period in premature newborns. This models are included GA, Apgar scores at 1 and 5 minutes of life, presence of respiratory failure at birth, invasive mechanical ventilation in the neonatal period, presence of intrauterine infection in the neonatal period and indicators of antioxidant protection (GSH, TAS/TAC; model 2). Conclusions: a comprehensive assessment of the clinical and anamnestic data of premature newborns at birth, as well as the determination of indicators that take into account the level of antioxidant protection, will make it possible to identify a premature baby at the risk for organic injury of the CNS and to correct the therapeutic strategies in the neonatal period.
Microbiota of the vagina and myoma nodes in uterine myoma
Authors: Nikitina E. S. , Rymashevsky A. N. , Naboka Y. L. , Rymashevsky M. A. , Gudima I. A. , Svirava E. G.
Published: July 2022

Objective: to study the microbiota of the vagina, myomatous nodes, their bed in patients with fibroids. Materials and methods: a comprehensive examination of 83 patients aged 26 to 50 years with diagnosed interstitial, interstitial-subserous uterine myoma was carried out. By age, all women are divided into 3 groups. Standard clinical and clinical laboratory studies, colposcopy, microbiological examination of the detachable posterior vaginal fornix, biopsy specimens of myomatous nodes and their bed, as well as morphological examination of biopsy specimens of myomatous nodes and their bed were performed.Results: in the structure of clinical manifestations of uterine fibroids, pain syndrome was the leading one (p<0.05). The number of myoma nodes in patients varied from 1 to 22. The duration of the operation and the amount of blood loss did not differ significantly (p>0.05). According to the results of a bacteriological study of the detachable posterior vaginal fornix in patients in the 2nd group, a decrease in the frequency of detection and the number of lactobacilli was revealed compared to the 1st group, and in women in the 3rd group, these microorganisms were absent. Among the anaerobic microorganisms in the 1st and 2nd groups, Eubacterium spp. dominated, in the 3rd — Peptostreptococcus spp. In patients of group 3, the frequency of detection of Bacteroides spp. was significantly increased (p<0.05). Among the aerobic spectrum of microorganisms in all groups, coagulasenegative staphylococci predominated. In a bacteriological study of biopsy specimens, the absence of growth of microorganisms in myomatous nodes was observed in 7.2% of cases, in the tissue of the bed of myomatous nodes in 17.7%. The microbiota of myomatous nodes and their bed in most cases was represented by anaerobic taxa. According to the results of a morphological study of biopsy specimens, no inflammatory reaction of tissues was detected. Conclusions: In women with uterine myoma of different age groups, multidirectional changes in the vaginal microbiota were revealed. In most cases, the myomatous node (92.8%) and its bed (82.3%) are not sterile with the dominance of anaerobic microbiota taxa. Identified significant correlations in the loci «vagina – myomatous node – myomatous node bed» indicate their relationship. The detection of various taxa of microorganisms in the myomatous node and its bed, according to morphological studies, is not associated with the presence of infectious and inflammatory processes in the tissues.
Modlitwa w ujęciu współczesnych teologów: Brunona Forte, Raniera Cantalamessy, Josepha Ratzingera i Jorgego Maria Bergoglia. Wybrane aspekty
Authors: Szkotak Anna , Dziemska Iwona , Wysocka Maja
Published: July 2022

Monografia omawia sylwetki i poglądy na temat zagadnienia modlitwy współczesnych teologów: Brunona Forte, Raniera Cantalamessy, Josepha Ratzingera i Jorgego Maria Bergoglia. W pierwszych rozdziałach zostały poruszone zagadnienia ogólne dotyczące modlitwy: modliwa w Starym Testamencie i modlitwa Jezusa, a następnie modlitwa w nauczaniu Kościoła. W kolejnych rozdziałach zaprezentowano sylwetki czterech współczenych teologów oraz ich wypowiedzi na temat modlitwy.
The Relationship Between Nonsuicidal Self-injury and Attachment: Protocol for a Systematic Review and Meta-analysis (Preprint)
Authors: Aghamohammadi Soudeh , Mazaheri M Ali , Fata Ladan , Mootabi Fereshteh
Published: July 2022

BACKGROUND

The prevalence of nonsuicidal self-injury (NSSI) is a major concern in public health. Two main factors (individual and environmental) cause NSSI. Studies addressing NSSI often consider it as an emotion regulation strategy. Studying NSSI within the framework of attachment theory is reasonable since the capacities to regulate emotion come into existence in the framework of attachment in the first periods of a child’s growth. Primary studies addressing this topic are not frequent, and no systematic review has been conducted.

OBJECTIVE

This systematic review and meta-analysis protocol aims to investigate the relationship between NSSI and attachment style and finding its relationship based on study design, study type, different types of attachments, and gender.

METHODS

All studies on the relationship between NSSI and attachment will be included in this systematic review. We will include observational studies (cross-sectional, cohort, and case control) through searches in electronic databases via PubMed, CINAHL, Embase, Web of Science, ProQuest, Scopus, PsycINFO, and Google Scholar as complementary search. Qualitative studies, case studies, case series, and letters to the editor will be excluded. There will be no language limitation. Moreover, there will be no limitations regarding the study participants’ age, gender, nationality, sexual orientation, and psychological problems. Funnel plots were examined if 10 or more studies are included, and the Begg and Egger statistical tests were used to assess the risk of bias. All similar data will be combined through the “metan” command by Stata statistical package (StataCorp). A fixed-effects or random-effects model, considering methodological similarities or differences, will be selected to determine a combination model.

RESULTS

We will summarize the selection of the eligible studies using a flowchart. The results will be presented in a table of evidence. The results of the meta-analysis will be depicted using diagrams and tables.

CONCLUSIONS

It seems necessary to carry out such systematic and comprehensive meta-analysis to present a summary of the published articles in terms of the relationship between NSSI and attachment. The results from this review will be used to improve our knowledge of the role of the upbringing of children and NSSI behavior and will help design appropriate interventions to address NSSI.

CLINICALTRIAL

PROSPERO CRD42021226455; https://tinyurl.com/yc77wny8

INTERNATIONAL REGISTERED REPORT

PRR1-10.2196/40808
Patient-Centered Outcomes Associated With a Novel Office-Based Opioid Treatment Program in a District Health Department: Mixed Methods Pilot Study (Preprint)
Authors: Coles Theresa , Chen Hillary , Des Marais Andrea , Sachdeva Nidhi , Bush Christopher , Macon Harrison Lisa , Guthrie Shauna
Published: July 2022

BACKGROUND

Granville and Vance counties have some of the highest opioid-related death rates in North Carolina, and have significant unmet needs with regard to opioid treatment. Medication for opioid use disorder (MOUD) is the most effective evidence-based approach to address opioid use disorder. Despite demonstrated efficacy and substantial need, access to MOUD is still insufficient in many parts of the United States. In order to connect patients with needed MOUD services, the district health department, Granville Vance Public Health (GVPH), established an office-based opioid treatment (OBOT) program.

OBJECTIVE

In this formative pilot study, we sought to describe patients’ goals and outcomes in a program delivered at a rural local health department using an integrated care approach.

METHODS

We used a mixed methods concurrent nested research design. The primary method of investigation was one-on-one qualitative interviews with active OBOT patients (n=7) focused on patients’ goals and perceived impacts of the program. Trained interviewers followed a semistructured interview guide developed iteratively by the study team. The secondary method was a descriptive quantitative analysis (79 patients; 1478 visits over 2.5 years) of treatment retention and patient-reported outcomes (anxiety and depression).

RESULTS

Participants in the OBOT program were 39.6 years of age on average, and 25.3% (20/79) were uninsured. The average retention in the program was 18.4 months. The proportion of individuals in the program with moderate to severe depression (Patient Health Questionnaire-9 scores ≥10) decreased between program initiation (66%, 23/35) and at the most recent assessment (34%, 11/32). In qualitative interviews, participants credited the OBOT program for reducing or stopping the use of opioids and other substances (eg, marijuana, cocaine, and benzodiazepines). Many participants noted how the program helped them manage withdrawal symptoms and cravings, which helped them feel more in control of their use. Participants also attributed improvements in quality of life to the OBOT program, such as improved relationships with loved ones, improved mental and physical health, and improved financial stability.

CONCLUSIONS

Initial data show promising patient outcomes for active GVPH OBOT participants, including reduction in opioid use and improvements in quality of life. As a pilot study, a limitation of this study is a lack of a comparison group. However, this formative project demonstrates promising patient-centered outcome improvements for GVPH OBOT participants.
Enrichment of multigrain cookies with tomato pomace powder
Authors: Kadam A.N. , Mane K.A.
Published: July 2022

Now a days baking industry is one of the large segments of food processing industries. Increased awareness of people led them change the eating pattern and choose healthy food including multigrain flour base products. Tomato pomace, a by-product from tomato processing is a source of valuable bioactive components and can be used in value added product preparation. The study was carried out to utilize tomato pomace powder in multigrain (wheat, finger millet and oats) cookies to assess the nutritive value and cost of prepared multigrain cookies. Multigrain cookies were prepared in four different proportions (whole wheat flour: tomato pomace powder as 31:2, 29:4, 27:6, and 25:8) by replacing the amount of whole wheat flour with the tomato pomace powder and subjected to quality evaluation (physical, sensorial, nutritional and functional) and production cost estimation. The results revealed highest acceptability of multigrain cookies prepared with 6% tomato pomace powder in terms of colour (8.1), taste (7.6), flavor (7.9), texture (7.6) and overall acceptability (7.9). The lycopene content (0.78-1.50mg/100g), beta carotene (30.14-124.15mcg/100g), total phenolic content (0.82-1.34mg GAE/g)and DPPH % inhibition (21.88-40.95%) exhibited increasing trend in developed cookies with increase in tomato pomace powder. The moisture, fat and carbohydrate content were decreased with increase in tomato pomace powder in multigrain cookies, whereas ash, protein and crude fibers showed increasing trend with increase in tomato pomace powder in cookies. The total cost of production for tomato pomace powder (6%) multigrain cookies was estimated as Rs. 200.55per kg.
Validation of a post-cracking law in tensile for a sustainable UHPFRC using fracture energy and finite element method
Authors: Aguero Rosangel Rojas , Aguirre Jose Rafael Yepez , Filho Américo Campos , Pacheco Alexandre Rodrigues
Published: July 2022

Ultra-high performance fiber reinforced concrete (UHPFRC) is an advanced composite material characterized by compressive and tensile strengths above 150MPa and 7MPa, respectively. Initially, an experimental procedure was used to characterize the tensile performance through bending tests, using beams with 1% and 2% content by volume of steel fibers. Three-point bending load arrangement notched prisms were used to determine the contribution of the fibers to reinforcing a cracked section. With that, the (F vs. ω) experimental curves were graphed, and from there, the analytic tensile curves (σ vs. ω) was obtained point by point by application of the inverse analysis procedure proposed by the AFGC. With the analytic curves, the fracture energy was calculated, following a procedure proposed by RILEM. Subsequently, the crack width was transformed into strain using a relationship that involves the characteristic length. The resulting analytical behavior law was used to carry out computational modeling applying the finite element method. Both the finite element method and the fracture energy were used to validate the procedures, comparing experimental and numerical results. Models and experiments showed good agreement and finally was determined the constitutive law for the UHPFRC in tension. It can be concluded from this study, therefore, that the post-cracking tensile behaviour of UHPFRC can be appropriately evaluated and validated through the applied analysis procedure in this research.
THE SELF-EXPANSION PROCESS AND QUALITY OF ROMANTIC RELATIONSHIPS
Authors: Đorđević Tamara , Vlajić Dušan
Published: July 2022

This paper examines whether people with different affective temperament (depressive, cyclothymic, hyperthymic, irritable, anxiety-cognitive, anxiety-somatic and mixed) differ in terms of perceived social support. The sample is a convenience one, uniform by gender, consisting of 200 people under the age of 35. The instruments used in the research are: the Serbian version of the TEMPS-A scale, which assesses five affective temperaments, and the Serbian version of the Social Support Scale of the Study of Medical Outcomes (MOS-SSS). The results show that the depressive temperament perceives social support to a lesser extent than the cyclothymic (p <.05), hyperthymic (p <.01), anxiety-cognitive (p <.05) and mixed temperament (p <.05). On the other hand, the hyperthymic temperament is more prone to perceiving social support than the cyclothymic (p <.05) and anxiety-somatic temperaments are (p <.05). The main conclusion of this research is that hyperthymic temperament, which is characterized by most desirable traits such as optimism, sociability, self-confidence and eloquence, perceives its social environment to be more supportive than other temperaments, which is a consequence of its characteristics and the adequate communication of its own needs.
Las vicuñas como problema de gobierno. Gubernamentalidad ambiental a múltiples niveles y disputas por el modelo de aprovechamiento de la especie
Authors: Cowan Ros Carlos Javier , Marcos María Florencia , Muro María Marta
Published: July 2022

En el artículo se analiza la emergencia y configuración de la vicuña como problema de gobierno y la producción de instituciones y dispositivos de regulación a múltiples niveles, desde la década de 1960 a la actualidad, focalizando en Argentina, como nivel nacional de gobierno, y en la provincia de Jujuy, como subnacional. Entre los resultados destaca el papel desempeñado por expertos/as que adhieren al paradigma del desarrollo sustentable e impulsan un modelo de conservación y aprovechamiento de la especie basado en el manejo en silvestría y en beneficio del poblador andino. A través de circular por diferentes ámbitos institucionales a distintas escalas, revistiendo diversos papeles, han conseguido disputar, institucionalizar y vigilar la implementación de ese modelo en oposición a otros que promueven un manejo pecuario con participación de empresas textiles.
“Quem manda no Mineirão?” Um estudo sobre a gestão do espaço urbano a partir da transformação do Mineirão de Estádio em Arena
Authors: Elizio Tharcio , Salgado Nayara de Amorim
Published: July 2022

Este artigo tem como objetivo produzir uma análise sobrea gestão do espaço urbano, baseada no estudo do Estádio Magalhães Pinto, o Mineirão, em Belo Horizonte, Minas Gerais. Chama-se atenção para a reforma, finalizada em 2012, e que transformou o estádio em termos físicos em uma arena multiuso. Também se comenta seu posicionamento em relação à cidade e à memória afetiva nesse espaço. Amparado em entrevistas e em análises documentais, este estudo investiga a gestão do estádio como um problema público, resultando em uma análise sobre a atuação dos agentes responsáveis, bem como sobre suas funções, responsabilidades, conexões de rede e diferenças do trabalho entre instituições. Identificam-se novas disputas sobre demandas que configuram o caráter de arena do novo Mineirão. Os apontamentos da pesquisa sugerem que o estádio não deve ser visto como um bloco uniforme, uma vez que diferentes instituições a serviço do Estado apresentam diferentes perspectivas sobre o uso do espaço urbano. Além disso, põe-se em perspectiva a atuação do Estado na gestão do Estádio Mineirão, no tocante à presença da iniciativa privada durante sua transformação em arena. Destaca-se o modo como as ações destoantes do Poder Público geram como consequência maior abertura de espaços de poder, aproveitados por outros atores que passam, então, a influenciar a gestão do estádio.