bluuebunny/crossref_metadata_2025 huggingface dataset:
Genetically Predicted Calorie Dietary Preference as a Causal Risk Factor for Multiple Cancer Types: Evidence from Mendelian Randomization
Authors: Zhang Kaiyuan , Lou Jiaheng , Huang Jianbo , Ni Xiaochen , Wang Chuhang , Guo Jianing , Fan Wei , Lv Ailin , Zhang Guangji , Jiang Tao
Published: February 2025

Background
There is evidence that diet and nutrition are modifiable risk factors for several cancers. however, the causal impact of dietary calorie preference on cancer development remains uncertain.
Methods
In this study, data on dietary calorie preference were sourced from a large-scale genome-wide association study (GWAS) database of food liking, while information on 18 cancer types was obtained from Finger R9 database. Two-sample Mendelian randomization (MR) analysis was conducted to assess the causal effects of Calorie Dietary Liking on 18 types of cancers. The inverse variance weighting (IVW) method was the primary analytical approach, with significant correlations further examined using Egger regression, MR-PRESSO, and weighted median methods.
Results
Our analyses revealed that a genetically predicted preference for high-calorie diets significantly raised the risk of non-Hodgkin lymphoma (NHL) (OR = 1.75, P = 0.006), non-small cell lung cancer (NSCLC) (OR = 1.39, P = 0.001), hepatocellular carcinoma (HCC) (OR = 2.06, P = 0.025), and gastric cancer (GC) (OR = 1.47, P = 0.012). Further subgroup analyses confirmed that high-calorie foods, particularly cheese liking, were strongly linked to an elevated HCC risk (OR = 2.43, P = 0.000), while deep-fried food liking were associated with increased NSCLC risk (OR = 1.26, P = 0.005). Low-calorie dietary liking showed causal association with the risk of prostate cancer (PCa) (OR = 0.85, P = 0.013).
Conclusion
This comprehensive MR analysis suggested that genetically predicted high-calorie food liking, as well as its subgroups, may be a risk factor in the development of NHL, NSCLC, HCC, and GC. A low-calorie diet may have a protective effect on the risk of PCa.
Targeted Chemoproteomics Identifies COEAE6G Esterase Driving Insecticide Cross-
Resistance in African Malaria Vector
Authors: Ismail Hanafy , Balaska Sofia , Grigoraki Linda , Lycett Gareth , Weetman David , Oladepo Folasade , Colman Fraser , Vontas John , Paine Mark
Published: February 2025

Pyrethroid insecticide resistance in the primary malaria vector, Anopheles gambiae, poses a
substantial challenge to ongoing control efforts in sub-Saharan Africa, where most malaria cases
and deaths occur. To combat this challenge, newer chemicals, including pirimiphos-methyl (PM)
are being used. To gain insight into how future resistance may develop to these compounds, a
proactive chemical proteomics approach was developed using activity-based protein profiling
(ABPP) in susceptible An. gambiae to identify enzymes interacting with pirimiphos-methyl (PM)
and its toxic metabolite PMO. We discovered 18 serine hydrolases (SHs) as primary targets of
PMO, including the carboxylesterase COEAE6G. Subsequent in vitro and in vivo validation
confirmed that COEAE6G confers resistance to PM, as well as cross-resistance to malathion,
permethrin and bendiocarb. This study underscores the utility of ABPP as a powerful tool for early
detection of potential resistance markers, such as COEAE6G, enabling the development of
effective resistance management strategies.
A Quantitative Approach to Mapping Mitochondrial Specialization and Plasticity
Authors: Picard Martin , Monzel Anna , Devine Jack , Kapri Darshana , Enriquez Jose , Trumpff Caroline
Published: February 2025

Mitochondria are a diverse family of organelles that specialize to accomplish complimentary functions 1-3. All mitochondria share general features, but not all mitochondria are created equal 4.Here we develop a quantitative pipeline to define the degree of molecular specialization among different mitochondrial phenotypes – or mitotypes. By distilling hundreds of validated mitochondrial genes/proteins into 149 biologically interpretable MitoPathway scores (MitoCarta 3.0 5) the simple mitotyping pipeline allows investigators to quantify and interpret mitochondrial diversity and plasticity from transcriptomics or proteomics data across a variety of natural and experimental contexts. We show that mouse and human multi-organ mitotypes segregate along two main axes of mitochondrial specialization, contrasting anabolic (liver) and catabolic (brain) tissues. In cultured primary human fibroblasts exhibiting robust time-dependent and treatment-induced metabolic plasticity 6-8, we demonstrate how the mitotype of a given cell type recalibrates i) over time in parallel with hallmarks of aging, and ii) in response to genetic, pharmacological, and metabolic perturbations. Investigators can now use MitotypeExplorer.org and the associated code to visualize, quantify and interpret the multivariate space of mitochondrial biology.
Remodeling of extracellular matrix collagen IV by MIG-6/papilin regulates neuronal architecture
Authors: Bénard Claire , Nadour Malika , LEATIS Robert VALETTE REVENO , BIARD Marie , Frébault Noémie , Rivollet Lise , ST-LOUIS Philippe , BLANCHETTE Cassandra R. BLANCHETTE , THACKERAY Andrea , PERRAT Paola , Bevilacqua Carlo , Prevedel Robert , Cappadocia Laurent , Rapti Georgia , Doitsidou Maria
Published: February 2025

Neuronal architecture established embryonically must persist lifelong to ensure normal brain function. However, little is understood about the mechanisms behind the long-term maintenance of neuronal organization. To uncover maintenance mechanisms, we performed a suppressor screen in sax-7/L1CAM mutants, which exhibit progressive disorganization with age. We identified the conserved extracellular matrix protein MIG-6/papilin as a key regulator of neuronal maintenance. Combining incisive molecular genetics, structural predictions, in vivo quantitative imaging, and cutting-edge Brillouin microscopy, we show that MIG-6/papilin remodels extracellular matrix collagen IV, working in concert with the secreted enzymes MIG-17/ADAMTS and PXN-2/peroxidasin. This remodeling impacts tissue biomechanics and ensures neuronal stability, even under increased mechanical stress. Our findings highlight an extracellular mechanism by which MIG-6/papilin supports the integrity of neuronal architecture throughout life. This work provides critical insights into the molecular basis of sustaining neuronal architecture and offers a foundation for understanding age-related and neurodegenerative disorders.
PNIPAM-Based Hydrogel-loaded Dicliptera Chinensis Polysaccharides -treated ADSC- derived exosomes promotes angiogenesis to accelerate healing in skin wound model
Authors: Mo Dongqin , Zhao Lixiang , Zhao Yanfei , Gao Linjing , Huang Yude , Fan Yiyang , Lu Haoyu , Wang Xian , Liu Zhiqing , Wang Yuetong , Li Yuetao , Wang Daiyou
Published: February 2025

Background
Promotion ofangiogenesis is a key aspect in accelerating wound healing. Therefore, exosomal therapy is a promising method for wound healing. Dicliptera Chinensis Polysaccharides (DCPs) have the potential to promote angiogenesis in tissues, and a hydrogel loaded with exosomes is an ideal delivery carrier. This study investigated the mechanism by which Pnipam-based hydrogel-loaded adipose-derived stem cell exosomes(ADSC-Exos) are stimulated by DCP in skin wound healing.
Methods
Exosomes secreted by adipose stem cells (ADSC-exosomes) was collected after stimulation DCP stimulation (DExos). In vitro experiments verified the ability of DExos to promote angiogenesis using the cell scratch technique, angiogenesis assay, RT-qPCR and Western Blotting using human umbilical vein endothelial cells (HUVEC) as a cell model. In vivo, a full skin defect was created on the backs of rats and Pnipam-based hydrogels loaded with DExo were injected into the defect. Wound healing was assessed morphologically and histologically.
Results
DExos promoted the cell migration rate and vasculogenic capacity of HUVECs and increased the cellular expression levels of CD 31, FGF 2, and VEGF-A. DExos-based poly(N-isopropylacrylamide) hydrogels (Pnipam@DExos) enabled the sustained release of DExos from the Pnipam-based hydrogel, which maintained high local concentrations at the wound site, promoting skin wound healing.
Conclusion
Pretreatment of ADSCs with DCPs improves the vasculogenic capacity of exosomes and pnipam@DExos promotes skin wound healing by slowly releasing DExos.
The potential of White Stork Ciconia ciconia nest lining to evaluate the functional diversity of coleopteran fauna – a case study of a novel non-invasive method of bioindicative evaluation across a land-use intensity gradient
Authors: Orłowski Grzegorz , Kitowski Ignacy , Czarnecka Joanna , Grzywaczewski Grzegorz , Ścibior Radosław
Published: February 2025

Collecting arthropod samples is usually very invasive because these organisms die during sampling, and it is hard to obtain a statistically robust sample. The availability of arthropods is critical for the survival of the youngest White Stork Ciconia ciconia nestlings conditioning the productivity of their populations; thus, the species is a strong predator of a variety of epigeic insects. At the time of the dietary shift and progressive drying of climatic conditions due to climate change or/and in dry habitats replacing wetlands, the role of such termophilic taxa as certain Coleoptera is often underestimated. Here, we evaluated the coleopteran component of the diet of the White Stork using the nest lining material, i.e. fragmented remains of regurgitated pellets, and related the community indices of Coleopteran fauna to the landscape structure within a radius of 2.5 km around nests. In eight nests in SE Poland, we found a massive accumulation of beetle remains representing 32 277 individual Coleopteran prey items, from which 17 252 were identified to the family level. Our analysis showed a significant relationship between the landscape structure and beetle communities, as well as the abundance of dominant prey taxa and share of three major functional guilds (herbivores, scavengers, and predators). The three most abundant prey taxa were large bodied epigeic taxa representing three families: carabidae, silphidae, and scarabidae, whose contribution increased with the share of tree cover and decreased with the share of arable land. The contribution of herbivorous and predatory beetles increased with the share of arable land. We have evidenced that the analysis of nest lining material provides a taxonomically informative data on beetle communities and can be a valuable tool in biondicative assessments of Coleopteran biodiversity. Given the widespread nesting of White Stork near landfills (increasing the productivity of their local populations), further studies assessing the role of the Coleopteran component, particularly the contribution of necrophagous or saprophagous beetles, in the diet of early nestlings of this bird species are essential.
Efficient and Scalable Data Pipelines: The Core of Data Processing in Gig Economy Platforms
Authors: Chen Junjie
Published: February 2025

The gig economy is characterized by rapid fluctuations in demand and a diverse array of data generated from various sources. Timely and efficient data processing is critical for platforms operating in this landscape, as they require real-time analytics to inform decision-making and enhance service offerings. In this paper, we introduce a comprehensive framework designed to develop efficient and scalable data pipelines tailored for gig economy platforms. Our framework focuses on systematically managing data processing tasks and offers a modular architecture that integrates multiple data sources seamlessly. It incorporates both stream and batch processing paradigms to optimize data flow and reduce latency. By utilizing microservices architecture, the framework enables independent component deployment, providing greater resilience and adaptability. Testing with extensive benchmarks on real-world datasets demonstrates improvements in processing speeds and resource efficiency in comparison to traditional methods, ultimately empowering gig economy platforms to handle large volumes of data effectively and respond adeptly to changing market dynamics.
The Incorporation of Mental Space Theory to the Analysis of News Headlines
Authors: Bikhtiyar Omar Fattah
Published: February 2025

Mental space theory as one of cognitive-semantic theories considers the operational process of mental space in connection to rational connectors that operate to find a basis for gathering mental and linguistic constructions in order to arrive at the units of meaning while interacting. This theory plays a pivotal role in establishing a basis for understanding how interlocutors create and utilize mental representations of various thoughts, especially while indulging in intricate thought processes helping interactants to generate novel ideas and solutions by combining elements from different contexts. Due to the restrictiveness in the number of words, and the focus on the most important theme, news headlines require concentration and sophistication in the process of analysis. Sometimes the readers may not arrive at the precise analysis of them. Therefore, this study hypothesizes that mental space theory can highly contribute to the analysis of news headlines. This study aims at identifying this theory comprehensively, on the one hand, and illustrates its contribution in the process of analysing news headlines, on the other hand. The current study employs a qualitative method in the process of data collection. It is qualitative for analyzing six selected news headlines with the application of mental space theory. The most significant concluding point that this study has derived is that mental space theory actively engages in illustrating the role of mind in determining the conceptual meaning of news headlines constituents
Exploring Mosul Food Proverbs: A Cognitive Perspective
Authors: Muhammed Idrees Hasan
Published: February 2025

Metaphor stands out as one of the most well-known theories that deal with non-literal language. This concept is viewed by Lakoff and Johnson (1980a) as understanding abstract concepts through more tangible objects. This view differs from other theories that consider metaphor as merely as a play of words. This research investigates the utilization of food metaphors in Mosuli Arabic proverbs. Its aim is to shed light on the bases and motives of these metaphors; furthermore, it seeks how abstract ideas are conceptualized and comprehended through the use of terms related to food in Mosuli Arabic proverbs. It hypothesizes that food-related terms are employed to comprehend and interpret a diverse range of abstract concepts. Furthermore, it suggests that the bases of metaphor are culture and experience.
Written and oral data are collected then analysed on two levels: the first level is concerned with getting the correct explanation and discourse scenarios where these proverbs might be used. The second level consists of two sub-levels.  Two models are used on the first part to investigate implicit metaphors. The two models are taken from the works of Lakoff and Turner (1989) on "GENERIC IS SPECIFIC" and Lakoff and Johnson (2003) on "Metaphors We Live By." Thus, the two models are used to reveal the metaphorical meaning of food in Mosuli Arabic proverbs. The second part investigates explicit metaphors using the paradigm proposed by Lakoff and Johnson (2003). This research concludes that the conceptual metaphor theory is able to reveal a various number of abstract ideas that are comprehended in reference to more tangible objects. Additionally, the metaphorical conceptualization is motivated by experience and cultural values.
From Feminine Anger to Rebellion: Martha’s Defiance in Lessing’s Children of Violence via Ahmed’s Resistance Theory
Authors: Bahmani Komasi Bahar
Published: February 2025

This study examines themes of anger and rebellion against societal constructions, traditions, and prescriptive roles in Doris Lessing’s Children of Violence series, focusing on the protagonist, Martha Quest, through Sara Ahmed’s concepts in Resistance Theory. In this framework, Martha’s anger, framed as a political rather than purely emotional response, serves as a catalyst for resisting and rebelling against oppressive structures in her pursuit of freedom and autonomy. This analysis explores how Martha’s anger, defiance, and rebellion empower her to reclaim her independence and challenge societal constraints. Moreover, this research highlights Martha’s resistance to traditional familial roles and restrictive expectations, enabling her to break down the “Good Woman” narrative and create space to express her authentic self. The findings reveal that Lessing tries to convey her critique of unequal social norms, emphasizing the transformative power of anger, defiance, and rebellion in reshaping identities and creating new spaces for women. She also presents anger as a conscious recognition of marginalization. Furthermore, this study provides a fresh critical study on Lessing’s work, highlighting the intersection of defiance, rebellion, and feminine political agency within a colonial context, and providing a new understanding of anger and rebellion as a source of empowerment and resistance.
(دەقئاوێزانی کولتوری لە دیوانی(کارێزە مەرجان)ی موحسین ئاوارەدا)
Authors: Ismail Hamadameen Sleman
Published: February 2025

پوختە
دەقئاوێزانی کولتوری لە دیوانی ( کارێزە مەرجان)ی موحسین ئاوارەدا، توێژینەوەیەکی زانستییە و بەرگی یەکەمی دیوانی (کارێزە مەرجان)ی (موحسین ئاوارە) وەک کەرەستەی ئەو توێژینەوەیە بەکارهاتووە. لە توێژینەوەکەدا پشت بە ڕێبازەکانی (وەسفی - شیکاری) بەستراوە ، ئەم توێژینەوەیە هەوڵێکە بۆ زیاتر شیکردنەوەی پەیوەندی نێوان کولتور و ئەدەب بە گشتی و شیعر بە تایبەتی و وێستگەی بە یەکگەیشتنیان. کولتور  بەشێکی گرنگی نەتەوەیە و هۆکاری سەرەکی مانەوە و زیندووهێشتنەوەی نەتەوەکانە.
لەم توێژینەوەیەدا کۆمەڵێک پرسیاری سەرەکی هەبوون بە پێی توانا وەڵاممان داوەتەوە، بۆ نموونە: چەمک و زاراوەی دەقئاوێزان چییە؟ یاسا و جۆرەکانی کامانەن؟ هەروەها چەمک و زاراوەی کولتور چییە و بەشەکانی کامانەن؟ ئایا موحسین ئاوارە لەم دیوانە شیعریەدا تا چ ڕادەیەک توانیویەتی گشت بەشەکانی کولتور دەقئاوێزانی ناو دەقی شیعرەکانی بکات؟ بەدرێژایی توێژینەوەکە هەوڵمانداوە بەشێوەی تیۆری و پراکتیکی وەڵامی ئەم پرسیارانە بدەینەوە.
توێژینەوەکە جگە لە پێشەکی و ئەنجام ولیستی سەرچاوەکان و پوختە لە دوو بەشی سەرەکی پێکهاتووە، بەم شێوەیەی خوارەوە: بەشی یەکەم خۆی لە دوو تەوەرەی سەرەکی دەبینێتەوە : تەوەرەی یەکەم باسی چەمک و زاراوەکانی دەقئاوێزان، پێناسەی دەقئاوێزان، باسی جۆر و یاسا و میکانزمەکانی دەقئاوێزان کراوە. تەوەرەی دووەمیش باسی چەمک و زاراوەی کولتور و پێناسەی کولتور، بەشەکانی کولتور کراوە. بەشی دووەم بەشێوەکی پراکتیکی بەرگی یەکەمی دیوانی (کارێزە مەرجان)ی شاعیر(موحسین ئاوارە)مان وەرگرتووە، بە پێی توانا گشت بەشەکانی کولتورمان باسکردووە.   
وشە سەرەکییەکان: (دەقئاوێزان، کولتور، موحسین ئاوارە ، دابونەریت، فۆلکلۆر)
Historical Solutions in Buildings in the Context of Current Problems of Green Architecture
Authors: RADZIEWICZ-WINNICKI Rafał
Published: February 2025

The paper discusses the current problems of green architecture in Poland, yet, its main purpose is to search for historical architectural solutions in the area of broadly defined users’ comfort, thermal comfort and ventilation. The aim of the work is to show an alternative development direction for energy-efficient architecture in relation to more and more strict thermal standards. The paper presents a number of interesting solutions, which, from the point of view of the current technological development, are examples of green architecture, where both energy-efficiency issues as well as thermal comfort and users’ health issues are crucial. The presentation of historic architecture examples is a pretext for a broader look at architecture and for showing contemporary rules, which do not always lead to the most important goal, that is, the creation of sustainable architecture focused on users’ health. The results of the studies cover the formulation of the most important, according to the author, solutions for the future of sustainable architecture. They can be used in the creation of new principles of truly green architecture, where energy efficiency will not conflict with users’ comfort and health.
Ways to Overcome the Implementation Problems of BIM- Technology Related to the National Standards in the Architectural and Building Industry of Ukraine
Authors: LEVCHENKO Oleksii , ANTONENKO Nadiia , KOSAREVSKA Raddamila
Published: February 2025

The paper describes the problems of intentions of the rapid introduction of BIM technologies in the construction industry of Ukraine. The research methodology involves analysis of national building standards, BIM technologies that have already been partially tested and a new logical structure of design processes in the logic of BIM technology in Ukraine. It is proposed to introduce into the design practice a number of actions aimed at harmonizing the key stages of BIM-technologies development with the regulatory framework. The European LOD stages and Ukrainian stages of designing are compared; it is proposed to introduce and gradation enshrine it in state building standards. The correctness problem of competitive tender documentation form for the development of project documentation in Ukraine is highlighted. The issue of the need for a detailed review of European Union standards in terms of national specifics and their gradual implementation in the Ukrainian legal framework was raised. It is proved that the proposed measures will improve the quality of design solutions in terms of economic feasibility and environmental friendliness, and government agencies will be able to qualitatively control all design and construction processes.
Assessment of Sustainable Concrete Using Carbon Black Dust as an Additive Admixture
Authors: PARASHAR Pravar , NAGAR Prityumn , NEEMA Ritik , KHADSE Rutul , NIM Ashish
Published: February 2025

Concrete is the most essential and demanding construction material that is mainly used to develop structural and nonstructural elements. Along with the better engineering properties, concrete has its drawbacks like the presence of pores and micro cracks, and this affects its properties like permeability and water absorption which tend to reduce its durability and strength. Carbon black dust (CBD) is one of the industrial byproducts that can be effectively used as an additive in concrete. It is a necessity for us to reduce environmental pollution arising due to CBD. This research paper attempted an investigation to assess the effect of CBD as an additive material into the concrete. The chemical properties of raw materials were determined by X-ray fluorescence (XRF) spectroscopy analysis and the mechanical properties of hardened concrete were carried out followed by destructive and non-destructive testing. Compressive strength of 150 mm concrete cubes was determined at 7th, 14th and 28th day of curing that contains various percentages (2.5%, 5%, 7.5% and 10%) of CBD. Concrete with 0% CBD served as the control specimen. On the basis of experimental investigations, the maximum compressive strength reported for concrete specimens containing 7.5% CBD as 17.23% was more than that of control specimen. At 10% CBD, strength got decreased but significant improvement with respect to control specimen was also noted. As per the chemical analysis, CBD contains substantial amount of fluxing and strengthening agents that improve the performance of concrete and it can be used as an additive admixture.
CHLORIDE CONTENT OF STREET CLEANING WASTE AND ITS POTENTIAL ENVIRONMENTAL IMPACT
Authors: GRONBA-CHYŁA Anna
Published: February 2025

According to the data of the Central Statistical Office for 2017, the average amount of municipal waste generated per capita is 486 kg. Poland ranks last but one in terms of the amount of municipal waste generated. About 56% of municipal waste is processed, but still about 40% is landfilled. They may contain chlorides, especially those from the winter period, resulting from the use of deicing agents. Chlorides cause salinity of surface and ground waters and soil salinity, which in turn leads to deterioration of water purity and a decrease in biodiversity of aquatic organisms, changes in the microbiological structure and increased toxicity of metals. Chlorides also damage road surfaces and bridges, corrosion of plumbing pipes. Once the chlorine-containing sweepers are deposited in a landfill, this waste may contribute to an increase in chemical aggressiveness, which is important in the design of anti-filtration barriers, and in the rehabilitation of contaminated land and soil. The level of water and soil salinity has a significant impact on the critical infrastructure, especially in terms of water supply – the risk of corrosion of pipes and their decline in species biodiversity. An important role in the critical infrastructure is played by the storage of dustmuds – the risk of failure of security measures in storage yards. Therefore, it is very important to determine the salinity level in this stored waste. The salinity level of street sweeping waste from different street locations is not commonly studied. Therefore, such a study was conducted for a midsized city. The study shows that the highest chloride concentrations in street and sidewalk sweeping waste are found around manholes and the lowest concentrations are found on sidewalks.

The aim of the research is to determine the amount of chlorides in sweepings in the annual cycle to determine the potential risk associated with their impact on selected aspects of the environment.
Types and Valorization of Sludge Generated in Water Treatment Processes
Authors: ŻOCZEK Łukasz , DUDZIAK Mariusz
Published: February 2025

This paper is a study on the problem of sludge formation in water treatment processes. Various physical and chemical processes used in technological systems of water treatment were described and those which are the source of sludge were indicated. The chemical composition of the sludge was presented, with particular emphasis on hazardous organic and inorganic pollutants. An essential part of the work was to consider the possibilities and ways of valorizing sludge. It was determined that the type of generated sludge depends on the applied process and its pollution degree depends on the type and quality of the water taken. Most of the sludge is formed during the coagulation process of surface waters, which may be contaminated with various heavy metals. Among the possibilities and methods of sludge valorization, an interesting way to use it is in construction, as an admixture to various building materials. It is also possible to use sludge as an unconventional adsorbent or reaction catalyst in the oxidation of organic pollutants present in wastewater.
Evolution mechanism of high-altitude dangerous rock mass collapse-debris flow chain disaster: a case of study in an open-pit mine
Authors: Wang Feifei , Jiang An-min
Published: February 2025

In order to reveal the mechanism of the chain disaster caused by the collapse of high-altitude dangerous rock bodies in high-altitude open-pit mines and the formation of debris flows, field survey method was used to clarify the morphology, range, and scale of the high-altitude dangerous rock bodies and debris flows. Combined with geological data of open-pit mines and mining technical conditions, the formation mechanism of high-altitude dangerous rock bodies and the causes of debris flow formation were studied. The laws of chain disaster evolution and disaster patterns were revealed. The research results showed that (1) the formation of the collapse-debris flow chain disaster is due to the coupling effect of internal poor engineering geological conditions and external factors such as rainfall, groundwater, freeze-thaw, and blasting vibration. The collapse mode of the dangerous rock body is tensile-crack and tipping, shear-sliding, and tensile-crack and seating. (2) The collapse disaster of high-altitude dangerous rock bodies in open-pit mines triggered the formation of debris flows by multi-level landslides in the open-pit mines. The overall evolution process of the chain disaster is “local landslide in the pit - collapse of high-altitude dangerous rock bodies - multi-level landslide debris flow in the pit - burying the pit”. (3) The two-dimensional finite element numerical simulation analysis shows that the safety factor of the slope of the open-pit mine is 1.06. The slope is in an unstable state, verifying the results of the collapse of high-altitude dangerous rock bodies on the slope and the formation of landslide debris flows. The research results can provide references for the measures to break the chain and control measures of the chain disaster caused by the collapse of mountain slopes - debris flows in high-altitude and high-altitude areas.
On the interdependence between specialization and structure of machinery exports: Case of European economies
Authors:   Institute of Europe of the Russian Academy of Sciences, Vasilchenko Alexander
Published: February 2025

The article dissects the intercourse between specialization and structure of exports of machinery and transport equipment in Europe in the latest years. In particular, the trends of increasing specialization of Poland, Czechia and Slovakia and decreasing specialization of Spain have
been studied. The hypotheses stating that export specialization in machinery and equipment depends on a stable export basket and diversifying geography of export have been empirically tested. The methodology applied was based on the exports’ decomposition onto intensive and extensive products and geographical margins, as well as calculation of revealed comparative advantage and trade intensity indices. It has been revealed that during initial increase in specialization Czechia and Slovakia actively diversified geography and formed sustained product
structure of their exports, then resorting to exports of established products to traditional importers. Unlike Czechia and Slovakia, the increase and the following decrease in specialization of Poland were accompanied with volatile export basket and stable geography of supplies.
The decrease in specialization of Spain developed amidst unstable product and geographical structure of exports. Hence, the first hypothesis has been proved for Poland, Czechia and Slovakia; the second one stays valid only for the initial growth of specialization of Czechia and Slovakia. It is suggested that the following research might be devoted to studying whether sluggish dynamics of Poland, as well as its incapacity to compete internationally in machinery and equipment, are caused by endogenous economic factors, such as lower productivity and lesser FDI inflow.
Sustainable development of society and economy in the focus of Russian and foreign economists: A view from St. Petersburg University
Authors:   St. Petersburg State University, Protasov Alexander , Markov Maxim ,   St. Petersburg State University, Merkulova Irina ,   St. Petersburg State University
Published: February 2025

The article is devoted to the study of the evolution of the theoretical views of the participants of the annual international scientific and practical conference “Sustainable Development: Society and Economy” on the problems of the development of the Russian and world economy over the eleven-year history of its work. Organized in 2014 by St. Petersburg State University, which celebrated its 300th anniversary in 2024, the conference has over the years become a recognized international platform for discussions on the most acute theoretical and applied
aspects of economic development. The stands and backstage of the conference have always been open to both world-renowned economists and novice researchers. The idea of writing the article appeared in 2023, when the tenth anniversary conference was held and it was possible
to begin to summarize the contribution of its participants to the development of economic thought and methodology of economic research, as well as to try to identify the features of the reflection of its participants on the global challenges faced by the Russian and world economy. The authors of the article considered it possible to limit themselves to analyzing only some, primarily theoretical areas of research, the most significant from the point of view of the current state of economics, the results of which were reflected in the reports and publications of the conference participants — this is the methodology of economic research and the history of economic thought, macroeconomic problems and environmental aspects of sustainable development, as well as issues of reforming economic education. A distinctive feature of the research presented in the article is that the main ideas and proposals made at the conference in different years were grouped according to appropriate criteria for ease of perception and
were preceded by a brief description of the state of theoretical and applied research in world and domestic economic thought on relevant issues.
Corporate and regional ESG ratings: Is there a connection?
Authors:   HSE University, Zotova Yana
Published: February 2025

The trend of creating ratings of the regions and companies based on the environmental, social and governance factors is on the current agenda. It is proven in practice and in numerous studies that there is a positive impact of ESG rating positions on the economic efficiency of companies: on the value of the company due to improving reputation and increasing labor productivity, on corporate profitability, credit ratings, rise in share prices, reducing the volatility of stock returns. As a result, there is a growing number of corporations interested in improving their assessment in a number of national and international ratings (this research
studies ESG Book, Morningstar Sustainalytics). At the same time, the consulting and rating agencies create ESG ratings of regions (World Economics Journal, Global Sustainable Competitiveness Index, Heritage Foundation), assessing countries according to the parameters of the sustainable development. The question is whether there is a mutual influence of the corporate and the regional ESG ratings. The purpose of this article is to identify whether there is a relationship between the factors of corporate ESG ratings and the ESG indicators of countries where these corporations are registered. The subjects of this study are corporate and regional ESG ratings. The methodological basis of this work is a regression analysis. The results showed a statistically significant relationship between the corporate ESG ratings and the regional indicators of sustainable development: both for individual ESG parameters and in a form of an integral assessment (ESG). Nevertheless, the regional ESG ratings have a limited impact on the number of corporate assessments of sustainable development, and this relationship is not as strong as the first one. It is possible that this relationship will become stronger over time, that can be a subject of further research. Countries all over the world are able to provide new tools in public policy to support companies in achieving goals of the ESG strategies, and, consequently, to improve their own regional indicators in a number of ratings, that can attract additional investments to the region and improve the quality of life of the society in the context of the ESG parameters.
Biomorphological features and productivity of Calendula L. in the conditions of the Cis-Baikal region
Authors:   Irkutsk State Agrarian University named after A.A. Ezhevsky, G. Khudonogova Elena , A. Khusheyeva Tamara ,   Irkutsk State Agrarian University named after A.A. Ezhevsky
Published: February 2025

Background. One of the valuable medicinal plants is Calendula officinalis L. Nu merous varieties and forms of Calendula L. have medicinal and ornamental properties. The purpose of the study was to investigate the biomorphological characteristics and productivity of Calendula raw materials in the Cis-Baikal region. Materials and methods. Varieties with double inflorescences were taken for testing: Calendula Orange King, C. Marigold. C. offic inalis served as a control. Wide-row sowing of seeds was carried out on May 11. The exper iments were repeated 10 times. Results. Mass emergence of seedlings is observed on May 25–29, the budding phase is May 5–8, the beginning of flowering is June 19–27, mass flowering occurs June 27 – July 4. The flowering period of the studied species and varieties is very extended, some shoots with buds go under the snow, not having time to open some of them. The largest number of buds that have not blossomed by September 25 was noted in the Orange King variety, the buds of this variety are large and form more slowly compared to the Marigold variety of calendula and C. officinalis. Conclusions. The optimal time for sowing Calendula seeds, in the conditions of the Cis-Baikal region, is the beginning of May (May 1–11), later sowing of seeds (May 20) leads to late flowering of plants, a delay in the opening of buds and a decrease in the yield of raw inflorescences. The yield of raw materials depends on the height of the plants, the number of lateral shoots with inflores cences, the number of blossomed buds and the diameter of the inflorescences. The lower growing C. officinalis and C. Orange King form a significant number of lateral shoots with inflorescences. The most productive is the Orange King variety. The use of humates increases the yield of Calendula raw materials by 1,1–1,5 times, while the content of chemical elements, except for iron, corresponds to the maximum permissible concentrations in medicinal raw materials. The highest level of carotenoids was found in the Orange King variety.
Power Efficient Counter Design using CNTFET with AI Integration
Authors: Khan Imran Ahmed , Shah Owais Ahmad , Nandan Durgesh , Rai Amrita , Mahajan Anurag
Published: February 2025

Background:

Reducing power consumption in digital circuits can be achieved by
minimizing the number of transitions, and Gray code provides a binary numeral system optimized
for this purpose. Traditional CMOS-based counters face limitations in power efficiency and
performance at nanoscale levels. This research presents a novel design of a Gray code counter
utilizing Carbon Nanotube Field-Effect Transistors (CNTFETs) as a high-performance alternative
to CMOS technology.

Methods:

The CNTFET-based Gray code counter was evaluated across a range of temperatures
(25°C to 100°C), input voltages (0.7V to 1.3V), and clock frequencies (200 MHz to 800 MHz).
Supervised machine learning was employed to predict and analyze key performance metrics,
including propagation delay, power consumption, and Power-Delay Product (PDP), for both
CMOS and CNTFET Gray code counters under varying conditions.

Results:

The results demonstrate that the CNTFET-based Gray code counter exhibits significantly
lower power dissipation, faster operation, and a minimum PDP compared to its CMOS
counterpart across the tested temperature, voltage, and frequency variations. The machine learning
predictions aligned closely with simulation results, confirming the accuracy of this approach in
optimizing the design.

Conclusion:

The study validates the CNTFET Gray code counter as a highly efficient, low-power
solution suited for high-performance applications. Its superior performance characteristics suggest
that CNTFET technology, coupled with AI-driven optimization, holds promise for advanced lowpower
VLSI circuit designs.
A Risk Warning Model for Anemia Based on Facial Visible Light Reflectance Spectroscopy: Cross-Sectional Study
Authors: Zhang Yahan , Chun Yi , Fu Hongyuan , Jiao Wen , Bao Jizhang , Jiang Tao , Cui Longtao , Hu Xiaojuan , Cui Ji , Qiu Xipeng , Tu Liping , Xu Jiatuo
Published: February 2025

Background

Anemia is a global public health issue causing symptoms such as fatigue, weakness, and cognitive decline. Furthermore, anemia is associated with various diseases and increases the risk of postoperative complications and mortality. Frequent invasive blood tests for diagnosis also pose additional discomfort and risks to patients.

Objective

This study aims to assess the facial spectral characteristics of patients with anemia and to develop a predictive model for anemia risk using machine learning approaches.

Methods

Between August 2022 and September 2023, we collected facial image data from 78 anemic patients who met the inclusion criteria from the Hematology Department of Shanghai Hospital of Traditional Chinese Medicine. Between March 2023 and September 2023, we collected data from 78 healthy adult participants from Shanghai Jiading Community Health Center and Shanghai Gaohang Community Health Center. A comprehensive statistical analysis was performed to evaluate differences in spectral characteristics between the anemic patients and healthy controls. Then, we used 10 different machine learning algorithms to create a predictive model for anemia. The least absolute shrinkage and selection operator was used to analyze the predictors. We integrated multiple machine learning classification models to identify the optimal model and developed Shapley additive explanations (SHAP) for personalized risk assessment.

Results

The study identified significant differences in facial spectral features between anemic patients and healthy controls. The support vector machine classifier outperformed other classification models, achieving an accuracy of 0.875 (95% CI 0.825-0.925) for distinguishing between the anemia and healthy control groups. In the SHAP interpretation of the model, forehead-570 nm, right cheek-520 nm, right zygomatic-570 nm, jaw-570 nm, and left cheek-610 nm were the features with the highest contributions.

Conclusions

Facial spectral data demonstrated clinical significance in anemia diagnosis, and the early warning model for anemia risk constructed based on spectral information demonstrated a high accuracy rate.
Perspective mapping: a new online technique for collecting quantifiable qualitative interview data (Preprint)
Authors: Mammen Jennifer , Tyo Mirinda , Seshadri Sandhya
Published: February 2025

BACKGROUND

Mixed methods research is essential to development of patient reported outcome measures, digital technology, and endpoint selection for clinical drug trials, and to advance clinical care, when complex health-related experiences cannot be fully understood by quantitative or qualitative approaches alone. New technology and opportunities for remote data collection have changed the ways in which qualitative and quantitative data can be collected, can enabling researchers to capture human experiences in ways not previously possible.

OBJECTIVE

This paper describes Perspective Mapping, a newer online interviewing technique that uses mind mapping software to capture in-depth qualitative data inside a quantitative measurement framework to understand and measure individual experiences.

METHODS

During online interviews, mind-mapping software is used to visually depict participant experiences. Structured concept maps are co-created in real time with participants, focusing on building detailed narrative descriptions about experiences and categorizing these within a predefined quantitative framework, such as the relative importance of different experiences relevant to a phenomenon. The approach combines semi-structured interviewing with technology enhanced card-sorting techniques, allowing participants to define and prioritize what matters most. The method ensures narrative richness alongside structured data collection, facilitating deeper understanding of the phenomenon.

RESULTS

Perspective Mapping emphasizes participant engagement in data generation and analysis and enables the simultaneous collection of qualitative narratives and quantitative assessment of key concepts. The technique has been successfully applied in research on chronic illness, symptom burden, and digital health technology. Advantages of the approach include systematic collection of qualitative data, transparent and structured data outputs, real-time data validation, and ability to return maps to participants as a form of reciprocity. Pragmatic factors such as interviewer capabilities, participant literacy, interview duration, and technology resources must be considered.

CONCLUSIONS

Perspective Mapping offers an innovative and engaging way to gather complimentary qualitative and quantitative data remotely. By blending qualitative depth with quantitative structure, the technique supports richer, more actionable insights for health research, policy, and beyond. This technique holds promise for applications in psychology, education, and other social sciences where comprehensive experience mapping is essential.

CLINICALTRIAL

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From Oppression to Hope: A Social Practice Approach to Reducing Heavy-Drinking with Midlife Women (Preprint)
Authors: Ward Paul Russell , Warin Megan , MacLean Sarah , Lunnay Belinda , Palmer Catherine , Meyer Samantha , Hughes Tonda , Lyons Antonia , Nicholls Emily
Published: February 2025

UNSTRUCTURED

Alcohol consumption remains a major societal problem, contributing to myriad health conditions and costing Australia $6.8 billion a year. Australian midlife women (45-64 years) consume more alcohol than ever – more than previous generations of midlife women and more than other age groups of women currently. Alcohol poses health risks unique to midlife women, including increased risk of breast cancer - 10% of breast cancers result from alcohol consumption and there is no ‘safe’ limit (every drink over the lifecourse further increases risk for breast cancer). There is a global gap in knowledge about socially and culturally appropriate interventions for reducing alcohol consumption in these heavy-drinking groups of midlife women.

This project aims to reduce alcohol consumption in 4 heavy drinking groups of midlife women by developing/testing co-designed interventions aimed at changing social practices around alcohol. This project expects to generate new knowledge on the personal, social and cultural drivers of heavy drinking using novel interdisciplinary approaches combining social practice theory, critical consciousness and pedagogies of oppression and hope. Expected outcomes include: community-level actions and policy/practice levers for alcohol reduction; and enhanced capacity for the research team to address the societal impacts of alcohol on the global stage. This should provide significant benefits in terms of reducing alcohol consumption for midlife women.
Application of the Supportive Accountability Model in Digital Health Interventions: A Scoping Review (Preprint)
Authors: Kwok Gary , Cheung Shannon Pui Ying , Duffecy Jennifer , Devine Katie
Published: February 2025

UNSTRUCTURED

The Supportive Accountability Model (SAM) is a theoretical framework designed to enhance adherence to digital health interventions (DHIs) through the incorporation of structured human support. Guided by SAM, this scoping review answers the following research questions: (1) What is the extent of research on human support factors and their influence on engagement with and adherence to DHIs? (2) What is the extent of research applying SAM (i.e., accountability, bond, and legitimacy) to improve engagement with and adherence to DHIs? Results of analysis (N = 36) indicated that SAM was inconsistently applied to intervention designs. Some studies used human support as the mode of intervention delivery rather than as an adjunctive tool focusing on improving engagement and adherence, as proposed by SAM. Aside from accountability, there was also a lack of explicit focus on other constructs within the model (i.e., legitimacy and bond), which was intended to examine pathways that explain adherence to DHIs. In sum, the current scoping review helps us better understand current uses of human support in DHI adherence and identifies future research opportunities to optimize the engagement with these interventions.