bluuebunny/crossref_metadata_2025 huggingface dataset:
Влияние ионизирующего излучения на спектрально-люминесцентные свойства органических сцинтилляторов UPS-923A
Authors:   Samarqand davlat universiteti, Нуритдинов И
Published: August 2023

Исследовано влияние гамма и электронного облучения на оптическое и ИК- поглощения, а также на фотолюминесценцию (ФЛ) образцов с полистирольной PS основой и добавками pTP и POPOP. Обнаружено уменьшение интенсивности люминесценции облученных образцов в областях 300-380 нм и 380-500 нм, которые коррелируют с изменениями сектров ИК-поглощения образцов, что обусловлена деградацией структуры ароматического бензольного кольца в матрице полимерной основы и деструкцией добавок.
THE NUMBER OF EIGENVALUES OF THE DISCRETE SCHRÖDINGER OPERATOR
Authors:   Samarqand davlat universiteti, Akhmadova Mukhayyo
Published: August 2023

In this paper we consider the family of Schrdinger operators, associated to the Bose-Hubbard Hamiltonian of a single boson on the one dimensional lattice . We find suffiently conditions for the parameters , such that the operator has no one eigenvalues below the essential spectrum and three eigenvalues above the essential spectrum.
IQLIM O‘ZGARISHLARI VA AHOLI KASALLIKLARINING HUDUDIY TARKIBI (JIZZAX VA SIRDARYO VILOYATLARI MISOLIDA)
Authors:   Samarqand davlat universiteti, Komilova N.K
Published: August 2023

Ushbu maqolada iqlim o'zgarishlari Jizzax va Sirdaryo viloyatlarining aholisi orasida kasalliklarni tarqalishiga ta'sir etuvchi omillar sifatida kuchli shamol kunlar soni, yanvar va iyul oylarida shamol tezligi, o'rtacha yillik havo harorati, yanvar va iyul o'rtacha harorat, yuqori namlik qayd etilgan kunlar soni, yomg'irli kunlar soni, bulutli kunlar soni, qishda ob-havoning qattiqligi, atmosfera qurg'oqchiligi kunlari soni kabi iqlim sharoitlarining aholi salomatligiga ta'sirini o'rganishning hududiy tarkibi ochib berilgan.
ДВУХФОТОННО-ВОЗБУЖДАЕМАЯ ЛЮМИНЕСЦЕНЦИЯ В ПОЛИЦИКЛИЧЕСКИХ АРОМАТИЧЕСКИХ СОЕДИНЕНИЯХ
Authors:   Samarqand davlat universiteti, Рахматуллаев И.А
Published: August 2023

Работа посвящена экспериментальному исследованию двухфотонно-возбуждаемой люминесценции в полициклических ароматических соединениях. Обнаружено, что при увеличении интенсивности возбуждающего излучения происходит деформация формы контура двухфотонно-возбуждаемой люминесценции, сопровождаемая увеличением амплитуды коротковолнового и уменьшении длинноволнового максимумов. В исследованных соединениях выявлен эффект суперлюминесценции.
MAHALLIY SUT ACHITUVCHI BAKTERIYALARNING ANTIMIKROB VA BAKTERIOSINOGEN FAOLLIGINI TADQIQ ETISH
Authors:   Samarqand davlat universiteti, D.K Nurmuhamedova
Published: August 2023

Maqolada laktobakteriya shtammlarining shartli-patogen izolyatlarga nisbatan antimikrob hamda bakteriotsinogen faolligi bo'yicha tadqiqot natijalari keltirilgan. Mahalliy sut mahsulotlari va ona suti bilan oziqlanadigan chaqaloqlarning ahlat na'munasidan sut achituvchi 28 ta bakteriyalar ajratildi va antimikrob faolikka skrining qilindi, ularning probiotik xususiyatlari o'rganildi. Аjratilgan sut achituvchi bakteriyalarning 28 ta izolyatlaridan 7 ta shtamm tanlab olindi. Tanlangan shtammlar klinik izolatlarga nisbatan yuqori mikroblarga qarshi faol zona namoyon etdi. Sut achituvchi bakteriyalar orasidan Weissella cibaria WC-1, Weissella cibaria WC-2, Weissella viridescens WV hamda Lactobacillus plantarum C-2 shtammlarini Bacillus subtilis bakteriyasiga nisbatan bakteriotsinogen moddasi mavjudligi aniqlandi.
ЧИСЛЕННОЕ МОДЕЛИРОВАНИЕ УРАВНЕНИЯ ГРОССА-ПИТАЕВСКОГО
Authors:   Samarqand davlat universiteti, Н.А Тайланов
Published: August 2023

В данной работе рассматривается спектральный метод Фурье с разделением шагом времени для численного моделирования уравнения Гросса-Питаевского. Получены приближенные решения уравнения Гросса-Питаевского с помощью численного программирование в среде Matlab. Показано, что предлагаемый метод значительно уменьшает вычислительные затраты. Это улучшение становится более значительным, особенно для больших временных эволюций.
Cut out the parasitic middle men!
Authors: Brembs Björn
Published: August 2023

Academic publishers have been parasitizing the public purse for long enough now. Steffen Böhm, director of the Essex Sustainability Institute, said it best: In his article, he mentions the successful SciELO project in South America. In a lot of ways, SciELO (scielo.org) is quite close to what I have been arguing for: SciELO means “Scientific Electronic

Library

Online” and is supported by the Brazilian and Chilean government.
The Second Arrangement
Authors: Royle Stephen
Published: August 2023

To validate our analyses, I’ve been using randomisation to show that the results we see would not arise due to chance. For example, the location of pixels in an image can be randomised and the analysis rerun to see if – for example – there is still colocalisation. A recent task meant randomising live cell movies in the time dimension, where two channels were being correlated with one another.
Thiết kế nhà bê tông cốt thép chịu động đất có phân loại kết cấu kháng chấn chính và phụ theo TCVN 9386:2012
Authors: Võ Mạnh Tùng , Phùng Quốc Định
Published: August 2023

When designing seismic resistance for reinforced concrete buildings with medium ductility class (DCM) according to TCVN 9386:2012 the load bearing structures are to be designed to meet the required ductilities. The design of ductile members is quite complicated [2] and the amount of reinforcement provided for seismic members is considerable. Even so, TCVN 9386:2012 also allows to ignore the contribution of some members to the global seismic load-bearing structural system (that are secondary seismic members) when the remaining members (primary seismic members) are sufficient to ensure the safety and stability of the building. This paper presents some basic principles of the selection, the modeling methods and the design principles of primary and secondary seismic members in reinforced concrete buildings.
Synthetic data generator for student data serving learning analytics: A comparative study
Authors:   Centre for Change and Complexity in Learning, University of South Australia, Australia, Zhan Chen , Blessed Deho Oscar ,   UniSA STEM, University of South Australia, Australia, Zhang Xuwei ,   Centre for Change and Complexity in Learning, University of South Australia, Australia, Joksimović Srećko ,   Centre for Change and Complexity in Learning, University of South Australia, Australia, de Laat Maarten ,   Centre for Change and Complexity in Learning, University of South Australia, Australia
Published: August 2023

Ongoing digital transformation in the education sector has led to an increased focus on learning analytics (LA). LA collects and uses students’ data to gain insights about students’ learning and to guide interventions and feedback. Although LA holds tremendous promise for enhancing teaching and learning, there are persistent concerns about the privacy and ethical ramifications of collecting and using student data. One potential solution is the use of Synthetic Data Generators (SDGs) which can learn from real data to generate synthetic data that closely resembles real data. This paper examines the performance of existing SDGs with student data, as well as their capabilities for serving LA. A comparative study was conducted by applying different SDGs in Synthetic Data Vault to real-world student data. We report the efficiencies of different generators and the statistical similarities between synthetic and real data. We test how well SDGs imitate the real student data by fitting generated synthetic data into commonly-used LA models. We evaluate the utility of synthetic data by the alignment of LA outputs trained using synthetic data to the ground truth of student learning outcomes recorded in real data, as well as with outputs of LA models trained by real data.
BENTUK PERUBAHAN FONOLOGIS DALAM BERKOMUNIKASI VIA WHATSAPP MAHASISWA UNIVERSITAS MUHAMMADIYAH MAKASSAR
Authors: Muliana Muliana , Adhari Aulia , Afni Nur , Indriani Rani , Rahmi Nur
Published: August 2023

Forms of Phonological Changes in Communicating Via Whatsapp Universitas Muhammadiyah Makassar Students. This study aims to describe the form of phoneme changes, addition of phonemes, and omission of phonemes for students of the Muhammadiyah University of Makassar, especially the 2017 Indonesian Language and Literature Education Study Program when communicating via WhatsApp. This research is descriptive qualitative. The results showed that the form of phonological changes that occurred included: phoneme changes (a) vowel phoneme /ai/ to /e/. (b) the phoneme /u/ becomes /o/. Error adding phonemes (a) adding phonemes /g/.(b) addition of the phoneme /t/. (c) addition of the phoneme /h/. Phoneme omission error (a) omission of phoneme /h/. (b) omission of the vowel phoneme /a/.
PROSES REDUPLIKASI PADA TEKS TERJEMAHAN AL-QUR’AN SURAH AL -WAQIAH
Authors: Puspitasari Andi , Rahmat Rahmat
Published: August 2023

The Process of Duplication of the Quranic Translation Text Surah Al -Waqiah. This study aims to describe the process of duplication in the translated text of the Quran Surah Al Waqiah. Qualitative type of descriptive research. The results of this study there are four types of duplication that occur, namely the repetition of all basic forms, partial repetition, repetition with affixing, and repetition of phoneme changes. Themeaning of duplication found is the meaning of 'many', the meaning of 'the deeds which are in the basic form of being done over and over again', the meaning of 'mutual', the meaning of 'level', expressing the meaning of 'very', expressing the meaning of 'resembling', and expressing the meaning of 'the highest level'. The conclusion of this study is that the discovery of the duplication process in the translation text of the Quran Surah Al Waqiah implies that the learning material for the duplication process in students and students can be taken from the translation text of theQuran.
Diffuse Cerebral Infarction Due to Massive Thromboembolism in A Young Male Patient With ALK-Positive Non-Small Cell Lung Cancer: Is the ALK Rearrangement Related to Thrombosis?
Authors: Urakci Zuhat , Tunc Sezai , Keskin Fatma , Arvas Hayati , Oruc Zeynep , Isikdogan Abdurrahman
Published: August 2023

The risk of thromboembolism is high in patients with lung adenocarcinoma, especially in patients with ALK rearrangement. The mechanism of thromboembolism due to ALK rearrangement is still unknown. Here, we present a case of diffuse cerebral infarction due to massive thromboembolism in a 25-year-old young male patient with lung adenocarcinoma and ALK rearrangement. Thrombosis, apart from metastasis, should be kept in mind when cranial symptoms develop in patients with lung cancer with ALK rearrangement. In addition, these patients should be followed closely in terms of thrombosis both at diagnosis and during treatment.
Detect Melanoma Skin Cancer Using an Improved Deep Learning CNN Model with Improved Computational Costs
Authors: Ganesh Gourav , Somasundaram K
Published: August 2023

Melanoma cancer has been considered as one of the deadliest cancers. Melanoma is a highly malignant form of skin cancer that originates from melanocytes, the cells responsible for producing skin pigment. It is characterized by the uncontrolled prolife-elation of abnormal cells, which have the potential to invade surrounding tissues and spread to distant parts of the body. In this work, we aim to classify the skin disease into 7 classes. Our objective is to propose a deep learning CNN model to improve the accuracy of melanoma detection by customizing the number of layers in the network architecture and activation functions followed by reducing the computational cost. A comparative study is made between the improved model and the use of pre-trained Models like Resnet, Dense Net, Inception, VGG and Dense Net-II which has been giving impeccable accuracy. The HAM10000 dataset is used for research and we have got better results for the proposed model. Also, graphical results have been obtained for the same.
Anesthesia in Intensive Care Unit
Authors: Franjic Sinisa
Published: August 2023

Intensive care of patients is performed, as a rule, in a modernly equipped Intensive Care Unit where patients are accommodated after major surgical procedures as well as those who require special medical care due to their general health condition and certain diseases. The values of modern intensive care units are successfully implemented in the work of the Intensive Care Unit, with special emphasis on continuous education and improvement of daily clinical practice. Anesthesiologists are actively involved in the entire process of perioperative care of transplant patients as far as preparation is concerned for placement on the transplant list, conducting anesthesia for an extremely demanding transplant procedure and postoperative intensive care.
Conversion of B.0 Lineage of Human Corona Virus (Covid-19) Into Notoriously Infecting Less Pathogenic and Immune Escape Omicron B.1.1.529.2.75.2 or BA.2.75.2 Variant
Authors: Kumar Chakraborty Asit
Published: August 2023

Human corona viruses appeared in December, 2019 at China and then within a span of 2 years such viruses (COVID-19) have gone deletions and mutations generating more infectious and death promoting variants like B.1.1.7 (Alpha) and B.1.617.2 (Delta) which were claimed half million deaths worldwide. The D614G and N501Y point mutations in spike protein appeared important for higher transmission and P4715L mutation in RdRP enzyme of ORF1ab polyprotein was also significant. However, since end of November 2021, an Omicron variant with 29 mutations on RBD domain of spike protein appeared in Africa which known as B.1.1.529 lineage which successively generated BA.1 and BA.2 variants. Omicron virus was highly infectious with immune escape properties but caused mild diseases. BA.2 omicron virus changed into BA.2.75.2 with more immune-escape and evasion properties. All omicron viruses had important 31ERS deletion on N-protein and 3675SGF deletion on nsp6 domain of ORF1ab which likely borrowed from B.1.1.7 by recombination. However, 69HV immune-escape deletion in B.1.1.7 and 157FR deletion in B.1.617.2 were not found in BA.2 variants. Its journey from BA.2.3, BA.2.9, BA.2.12, BA.2.48 etc and finally BA.2.75 variant was happened within a span of 10 months and BA.2.75.2 was highly spreading in India and USA recently. Although BA.2.75.2 variant has unique T607I and D1119N mutations in spike protein, other common N440K, G446S and L452R mutations were necessary for higher immune-escape and transmission including D614G and N501Y mutations. A G44R mutation in ORF3a protein also appeared specific for BA.2.75.2 and a 26 bases deletion in the 3’-UTR (5’-gag gcc acg cgg agt acg atc gag tg-3’) found in omicron viruses may be responsible for weak viral load and pathogenicity as such deletion was not found in deadly B.1.1.7 and B.1.617.2 variants. The genetic changes in BA.2.75 sub-variants as well as other emerging omicron variants like BA.4.6, BA.5.2.1, BE.1.1, BQ.1 and BF.7 also have been discussed.
Diagnostic Techniques for Corona Virus
Authors: Akram Muhammad , Laila Umme , Talha Khalil Muhammad , Anwar Hina , Zainab Rida , Shahid Nimra , Mohamed Hamouda Ibrahim
Published: August 2023

For the early management of disease, infection & identification of corona virus for this purpose diagnostic testing is very effective because it provides significant effectiveness for the identification of cause. Number of tests are performed to investigate this viral infection but in some health institutions most of the tests are not present like viral traditional culture because for this purpose biosafety 3 level facilities are required. Currently one of the effective tests for the identification of covid 19 includes polymerase chain reaction real time reverse transcription. So, in all around the world this method is effectively used to detect the short acute respiratory syndrome corona virus. Some molecular test which performed for this purpose includes swab of oro-naso-pharyngeal also performed saliva & sputum test and for this purpose testing kits are available.
Breast Cancer Classification According to Immunohistochemical Markers: Clinicopathologic Features in Women Treated at Pietersburg Hospital, Limpopo, South Africa
Authors: O. Ooko Francis , R. Mphahlele Joyce , Bhuiyan Mirza M.U.Z , Van As Sebastian
Published: August 2023

Background: Breast cancer molecular subtypes can provide critical prognostic information that is useful to individualize care in addition to avoiding unwarranted adjuvant chemotherapy in some patients. Micro-array-based genetic profiling used to type breast tumors is expensive and unavailable for most low- and middle-income countries. Molecular subtyping using immunohistochemical (IHC) markers has proved to be a viable alternative. We therefore used this immunohistochemical technique to classify the breast cancer subtypes in our patient population and evaluated its association with clinicopathologic characteristics in these patients. Patients and Methods: We retrospectively evaluated immunohistochemical marker results (oestrogen, progesterone and Human Epidermal Growth Factor Receptor-2 (HER2) receptors) of 254 breast cancer patients treated at a tertiary referral hospital from 01 January 2010 to 31 December 2011 against their clinicopathological variables. Results: Out of 329 patients with invasive breast cancer treated within the study period 254 who had complete IHC marker test results were evaluated. Of these 136(54%) were luminal A, 69(27%) triple negative breast cancer (TNBC), 29(11%) HER2- enriched, and 20(8%) luminal B. The mean age at diagnosis was 55.6, 54.4, 54.2, and 52.3 years for luminal A, TNBC, HER2, and luminal B, respectively. The rate of lymph node involvement was 80%, 66.7%, 66.2%, and 58.6% for luminal B, TNBC, luminal A, and HER2, respectively. There was no association between molecular subtypes and clinical stage (p=0.578) or distant metastasis (p = 0.940). Grade 3 tumors were most prevalent in TNBC (59.4%) followed by luminal B (40%), HER2 (37.9%), and luminal A (37.5%). Five-year survival was 27.2%, 25%, 24.1% and 23.2% for luminal A, luminal B, HER2 and TNBC respectively (p=0.104). Conclusion: A large proportion or our patients (22.8%, n=75) with missing IHC test results could not be classified into breast cancer molecular subtypes and may have missed an opportunity for an individualized care. There is need for IHC tests in every breast neoplasm biopsy specimen to include ER, PR, HER2, and Ki67 markers for classification of the lesion according to molecular subtypes.
An Improved and Efficient Content-Based Medical Image Retrieval Technique vs State-of-Art Texture Feature Extraction Techniques
Authors: Kusi-Duah Samuel , Appiah Obed , Appiahene Peter
Published: August 2023

Areas in the health sector such as X-rays, Dermatology, High-resolution Computed Tomography – HRCT, Endoscopy, Radiology, Cardiology and Magnetic Resonance Imaging – MRI heavily depend on medical images for their activities hence it has become complex for managing and accessing these images from their repositories. As a matter of concern content-based medical image retrieval-CBMIR has been the system proposed by many researchers for handling access to similar medical image(s) as the input image, yet there is a caveat that has to be addressed with respect to which technique best suits CBMIR system with respect to a given performance metric. Medical images are mostly of grayscale and therefore color feature extraction techniques may not work effectively on them. Since there is no clear indication of which of the various texture feature extraction techniques is best suited for a given performance metric, this work seeks to comparatively evaluate the performance of the following state-of-the-art texture feature extraction techniques; Local Binary Pattern (LBP), Gabor Filter, Gray-Level Co-occurrence Matrix (GLCM), Haralick Descriptor, Features from Accelerated Segment Test (FAST) and a Proposed Technique using the metrics; Precision, Recall, F1-score, Mean Squared Error (MSE), Accuracy and Time. The results showed that the proposed technique is best suited for systems focusing on precision with an average precision score of 100% over 10.5k of raw medical images (dataset) using an appreciable minimum time with time complexity of 0(n).
Predictors of Time-to-Death Among Under-Five Children in Benishangul-Gumuz Regional State, Ethiopia: A Cross-Sectional Study
Authors: Gebrerufael Gebru Gebremeskel
Published: August 2023

Background: Although Ethiopia attained the fourth-millennium development goal, it promised to decrease the under-five children's death rate in 2015. However, the under-five children death rate has still remained a major public health problem in the Benishangul-Gumuz Regional State at the country level. Therefore, this study aimed to assess the predictor factors associated with the under-five children death rate in the Benishangul-Gumuz Regional State. Methods: A community-based retrospective cross-sectional study design was used. The information gathered from 906 children born five years preceding the survey was measured. Variables such as maternal and child demographic characteristics, health, and environmental factors were measured as predictor factors of under-five children's death rate. The study used descriptive statistics, and Cox Proportional-hazard (PH) regression model to identify the major significant predictor factors associated with under-five children's death rate. Results: The overall prevalence of experiencing under-five children death rate was 9.3% [95%CI: 0.0738, 0.112] in the Benishangul-Gumuz Regional State. The Cox PH regression model analysis revealed, being multiple births (AHR = 2.17; 95% CI (1.17–4.20)), using unprotected well water (AHR = 2.13; 95% CI (1.32–3.42)), parity between 6–8 (AHR = 3.16; 95% CI (1.40–7.16)) and 9 and above (AHR = 7.86; 95% CI (2.23–27.72)), the agricultural sector of mother’s occupation (AHR = 0.39; 95% CI (0.20–0.76)) and family size (AHR = 0.74; 95% CI (0.60–0.93)) were significantly associated with a higher risk of under-five children death rate. An increment in family size and parity increases the risk of under-five children's death rate. Conclusions: The study identified the source of drinking water, family size, parity, mother’s occupation and type of childbirth were the predictor factors significantly associated with under-five children death. The prevalence of under-five children death rate shows that Benishangul-Gumuz Regional State was experiencing a higher death rate than the national level. Therefore, both government policymakers and other concerned organizations should be given special attention to the major predictor factors of the under-five children's death rate and do greater emphasis on decreasing under-five children's death rate, and health intervention policies must be studied.
Prevalence of Ischemic and Hemorrhagic Stroke among Geraitic Patients Admitted in the Public Tertiary Care Hospitals of Peshawar
Authors: Haider Zeeshan , Sajid Hussain Sayed
Published: August 2023

Background: Stroke is a life-threatening medical condition that can result in lifelong brain impairment, complications, and demise. Stroke is the world's second biggest cause of mortality and could soon overtake as the biggest cause of death globally. It has 2 major pathological types’ i.e., ischemic stroke and hemorrhagic stroke. Hypertension, diabetes mellitus, cardiac diseases, smoking, physical inactivity and age are the risk factors that contribute in the occurrence of a stroke. Objective: To find out the epidemiological status of stroke types among patients admitted in the public tertiary care hospitals of Peshawar. Methodology: A descriptive cross-sectional study was carried out to determine the prevalence of stroke types in tertiary care hospitals of Peshawar. The sample size calculated for the research study was 109. Convenience sampling technique was used in this study. Results: This study was performed among 109 research participants. The most affected were males as 51.13% and females were 45.87%. And the rate of ischemic stroke was 71% while that of hemorrhagic stroke were 28%. Conclusion: the current research study concluded that majority of the patients had ischemic stroke as compared to the hemorrhagic stroke.
Evaluation of Changes in Coagulation Factors in Fresh Frozen Plasma during Storage at -18°C for 5 weeks at KISII Teaching and Referral Hospital
Authors: O. Ogolla Collince , N. Demba Rodgers
Published: August 2023

Background: Fresh frozen plasma is a critical substitute therapy in management of bleeding. Increased risk of venous thrombosis has been described to be associated with high plasma levels of several coagulation factors. Methodology: This study was a longitudinal study involving time series analysis of fresh froze plasma stored at -18°C for five weeks. A sample of 180 ml plasma was obtained from the blood centrifuged at 4000rpm which was aliquoted into three parts each containing 60ml. The first aliquot was used to assess the changes in coagulation factors in FFP at baseline during the first week of sample collection, the second aliquot was used to assess the changes in coagulation factors in FFP storage at -18°C temp after three weeks of storage, the third aliquot was used to assess the changes in coagulation factors in FFP storage at -18°C temp after five weeks of storage. Coagulation factor analysis was performed using Erba Mannheim ECL 105 coagulation analyzer, India factor results recorded. Thawing for subsequent coagulation factor analysis and serial testing of stored cryoprecipitate and fresh frozen plasma was done using Stericox Plasma Thawing Bath at 37°C, for 45 mins before before analyzing the samples. Standard storage conditions for the aliquots were monitored and maintained to ensure homogeneity. Results: The findings showed significant changes in the coagulation factors in FFP during storage at -18 for a period to five weeks with chi-square value of 216.000 and asymptomatic significance value (p-value) <0.0001* less than the standard alpha 0.05. Conclusion: There was a constant decrease of coagulation factors in fresh frozen plasma during storage at -18°C for 5 weeks at Kisii Teaching and Referral Hospital, Kisii County.
Base Excision Repair: A Review
Authors: Sidhu Ashwin
Published: August 2023

Base excision repair (BER) is a fundamental DNA repair pathway essential for maintaining the genomic integrity of all living organisms. This paper provides an overview of the mechanisms, key players, and regulatory aspects of the base excision repair pathway. BER serves as the primary defense against spontaneous DNA damage arising from endogenous and exogenous sources, including oxidative stress, deamination, and alkylation. This repair process involves a sequential series of enzymatic reactions orchestrated by various proteins, including DNA glycosylases, AP endonucleases, DNA polymerases, and DNA ligases.
Darier's Disease: Case Report
Authors: Lastre Melba Gonzalez , Rojo González Jojansy , Martin Alonso Isis Esther , Rodríguez Herrera Elsa , Rodríguez Eric Fuentes , Díaz López Frank , Pérez Sánchez Daysi , Plain Pazos Claribel
Published: August 2023

Darier’s disease, or Darier-withe disease, also known as follicular dyskeratosis is an acantholytic and dyskeratotic Geno dermatosis. associated with intrinsic lesions of the inter keratinocyte adhesion systems; Usually begins between the first and second decade of life not affecting seborrheic areas with keratotic papule, very pruritic. There is no curative treatment. The psychosocial consequences caused by the appearance of the lesions and their chronic condition constitute the greatest concern. A 58-year-old female patient with a diagnosis of Darier’s disease based on clinical and family history is presented.
Post-surgical Bleeding Disorders in Neuroblastomas Causes and Treatments
Authors: Gentil Martins Antonio
Published: August 2023

A patient is shown that has presented with a large abdominal neuroblastoma having had a laparotomy for tumor removal, followed by signs of low blood pressure, paleness, tachycardia, sweating and with wound oozing, after a few hours silent period, raising immediately the possibility of the need for an emergency re-laparotomy. This patient calls attention for the need to study pre-operatively the preoperative level of phospholipid antibodies as a possible cause for an autoimmune reaction to be delt with only medically and avoiding dangerous and unjustified surgery.
Post-Traumatic Feelings of Vulnerability, Psychological Disability, And Connection to Others in Victims of the 2016 Seka Train Derailment in Cameroon
Authors: Tojuin Boris Goula , David Nkarnyu Ngeh
Published: August 2023

The problem here is that of the restructuring of the link to the other of the psych traumatized person. The objective here is to apprehend the mechanism by which the feeling of vulnerability in the victim of a serious traffic accident, entered in a situation of disability, affects his or her link to the other. Following a qualitative approach, focused on the case study, the data were collected through semi-directive interviews with three victims of the 2016 Seka train accident. For this purpose, thematic content analysis was favoured. According to the results, the link to the other of the psych traumatized person (PP) is declined according to the instinctual unbinding, the attempt of the ego to restore the balance within the psychic spaces in humans. Also, they show that after a serious traffic accident, the organizers of the link are re-focused and can preserve their initial character just as they can be tainted by a feeling of pity. In this case, they plunge the victim into a fusional and/or conflictual relationship, generating a feeling of uselessness, a functional discomfort and a decrease or even a loss of self-esteem.
A Rare Case of Placental Site Trophoblastic Tumor
Authors: Wijeratne Yapa , Hapuachchige Chintana , Ojithmali Madara , Wickramasinghe Namal , Nagasinghe Sanjaya
Published: August 2023

Placental site trophoblastic tumor (PSTT) is a rare entity of malignant gestational trophoblastic neoplasia (GTN) with an incidence of 0.23 to 3% of all gestational trophoblastic diseases (GTD). They originate from intermediate trophoblastic cells of the placenta. They are slow-growing tumors and less chemo sensitive. Per vaginal bleeding following a miscarriage is not uncommon, however malignant variants of gestational trophoblastic neoplasia also could be a possibility. We are reporting a 24-year-old who was an otherwise healthy female who presented with persistent per vaginal bleeding following the first-trimester miscarriage in her second pregnancy. Initial histology of suction evacuation for her miscarriage has shown a partial mole. Since she continues to have per vaginal bleeding even a month later, repeat evacuation was done and beta hCG was high (2132mIU/ml), she was treated with a methotrexate regime. During follow up there was a slow rising of beta hCG level and hysterectomy was carried out due to the suspicions of invasive mole or PSTT. Histology confirmed a placental site trophoblastic tumor and her recovery and follow-up were uneventful.
Multiple Polycystic Organs in A Middle Age Female: A Rare Case of More Than Ten Years Without Surgical Intervention
Authors: A M Khair Randa Zaki , Musa M Ibrahim Mohamed Toum
Published: August 2023

Some organs are recognized to develop cysts more common than others do; these include the kidney the liver, the pancreas and the spleen. The structure and function of these organs may play a role. The frequency of polycystic kidney is variable. It is reported as 50 or less in 100000 (5 in 10000), 1 in 400 and 1 in 1000 life birth. Prevalence of autosomal dominant polycystic kidney disease (ADPKD) is thought to be overestimated by 2 to 5 folds. Multiple polycystic organs are not common, and reviewing the literature revealed some case reports, which indicates that such cases do not have regular pattern. Inherited polycystic kidney disease has two varieties; autosomal dominant polycystic kidney disease (ADPKD) and autosomal recessive polycystic kidney disease (ARPKD).
Schnitzler Syndrome: Clinical Case and Review of The Literature
Authors: Dimchova N. , V Broshtilova , Batashki A. , Bezhanova S. , Velevska J. , Yungareva I. , Marina S.
Published: August 2023

Schnitzler syndrome is a rare auto-inflammatory disease with a chronic relapsing course, characterized by recurrent urticarial lesions and monoclonal gammopathy. The manifestations of systemic inflammation are complemented by fever, bone and muscle pain, arthralgia/arthritis, lymphadenopathy, hepato- or splenomegaly, increased levels of acute inflammatory markers. A biological marker of the disease is the monoclonal gammopathy. Patients show high risk to develop AA-amyloidosis and lymphoproliferative diseases. A patient with a 5-year delay in diagnosis, who has responded well to systemic corticosteroids is presented. A comprehensive review of the new insights of disease pathogenesis and therapy is also highlighted.
Case Report of Delayed Treatment of Lepromatous Leprosy Masquerading as Acne Vulgaris in Post Elimination Era in Nepal
Authors: Giri Latika , Acharya Suyash , Bhandari Niroj , Sharma Grishma , Gautam Prabesh
Published: August 2023

Leprosy affects multiple systems and causes morbidity. However, with attainment of global elimination, and prevalence being 0.89/10000 at national level in Nepal; it is seldom considered a diagnosis when it doesn't manifest telltale signs. Leprosy can masquerade various dermatological, orthopedic or neurological problems thus delaying the diagnosis.
Lingva Kritiko (1932-1935): La unua esperantologia periodaĵo
Authors: Pabst Bernhard
Published: August 2023

Lingva Kritiko (Language Critique) was the first specialized periodical dedicated exclusively to 'Studies and Notes on Grammar, Dictionary and Style' of Esperanto. As a monthly supplement to Heroldo de Esperanto, 112 pages of volume 1 were published in Cologne between 1932 and 1935 until publication ceased due to the economical and political pressure in Nazi Germany. With its many discussions on esperantology the periodical is still of more than historical interest. An annotated chronological index references disputes then current over such issues as neologisms and technical terminology, the passive participles, and the objective genitive.
Impact of NaCl concentration in crystalline nanocellulose for printed ionic dielectrics
Authors: Franklin Elizabeth G , Smith Brittany , Franklin Aaron D
Published: August 2023

While electronics continue to be an integral part of nearly every aspect of our lives, there is a growing need for more environmentally friendly electronic materials and manufacturing processes. The use of crystalline nanocellulose (CNC) as a biodegradable dielectric material has recently gained interest due to its high capacitance at low voltages and compatibility with additive manufacturing techniques, such as printing. The addition of salt to the CNC has shown improved performance in transistor applications, but a thorough study optimizing the addition of NaCl in CNC capacitors has not been completed. We hypothesized that increasing the NaCl concentration altered the charging characteristics of the CNC. In this work, we verified this hypothesis by measuring the charging and discharging characteristics for CNC capacitors with varying NaCl concentrations and extracting the resistance-capacitance (RC) delay and charging current. These aerosol jet printed capacitors consisted of graphene top and bottom electrodes and a CNC dielectric sandwiched between the electrodes. The results reveal a minimum charging current at a NaCl concentration of 0.05%, independent of the applied voltage, and a minimized RC delay at NaCl concentrations above 0.1% with applied voltages below 2 V. These findings show that there are trade-offs that must be managed between RC delay and charging current, thus the NaCl concentration must be optimized for each application. This work is another significant step in understanding the electrical properties of CNC so that this environmentally friendly material may one day be utilized in commercially available electronics.
A Deep Learning Approach for Human Facial Expression Recognition using Residual Network – 101
Authors: Kumari Ranjana , Wasim Javed
Published: August 2023

Emotion recognition is a dynamic process that focuses on a person's emotional state, which implies that the emotions associated with each individual's activities are unique. Human emotion analysis and recognition have been popular study areas among computer vision researchers. High dimensionality, execution time, and cost are the main difficulties in human emotion detection. To deal with these issues, the proposed model aims to design a human emotion recognition model using Residual Networks-101 (ResNet-101). A Convolutional Neural Network (CNN) design called ResNet-101 solves the vanishing gradient issue and makes it possible to build networks with thousands of convolutional layers that outperform networks with fewer layers. An image dataset was used for this emotion recognition. Then, this image dataset was subjected to preprocessing to resize the image and eliminate the noise contents present in the images. After preprocessing, the image was given to the classifier to recognize the emotions effectively. Here, ResNet-101 was used for the classification of six classes. The experimental results demonstrate that ResNet-101 models outperform the most recent techniques for emotion recognition. The proposed model was executed in MATLAB software and carried out several performance metrics. The proposed architecture attained better performance in terms of accuracy 92% and error with 0.08 and other performances like 92% of precision, 85% of specificity and 98% of sensitivity so on, and this shows the effectiveness of the proposed model to existing approaches such as LeNet, AlexNet and VGG. In comparison to current techniques, the suggested model provides improved recognition accuracy for low intensity or mild emotional expressions.
Is it quality, is it redundancy, or is model inadequacy? Some strategies for judging the appropriateness of high-discrimination items
Authors: Ferrando Pere J. , Morales-Vives Fabia
Published: August 2023

When developing new questionnaires, it is traditionally assumed that the items should be as discriminative as possible, as if this was always indicative of their quality. However, in some cases these high discriminations may be masking some problems such as redundancies, shared residuals, biased distributions, or model limitations which may contribute to inflate the discrimination estimates. Therefore, the inspection of these indices may lead to erroneous decisions about which items to keep or eliminate. To illustrate this problem, two different scenarios with real data are described. The first focuses on a questionnaire that contains an item apparently highly discriminant, but redundant. The second focuses on a clinical questionnaire administered to a community sample, which gives place to highly right-skewed item response distributions and inflated discriminant indices, despite the items do not discriminate well among the majority of participants. We propose some strategies and checks to identify these situations, so that the items that are inappropriate may be identified and removed. Therefore, this article seeks to promote a critical attitude, which may involve going against routine stablished principles when they are not appropriate.

Cuando se desarrollan nuevos cuestionarios, tradicionalmente se asume que los ítems deben ser lo más discriminativos posible, como si esto fuera siempre indicativo de su calidad. Pero en algunos casos estas discriminaciones elevadas pueden estar ocultando algunos problemas como redundancias, residuales compartidos, distribuciones sesgadas o limitaciones del modelo que pueden contribuir a inflar las estimaciones de la discriminación. Por lo tanto, la inspección de estos índices puede llevar a decisiones erróneas sobre qué ítems mantener o eliminar. Para ilustrar este problema, se describen dos escenarios diferentes con datos reales. El primero se centra en un cuestionario que contiene un ítem aparentemente muy discriminante, pero redundante. El segundo se centra en un cuestionario clínico administrado a una muestra comunitaria, lo que da lugar a distribuciones de respuesta de los ítems muy sesgadas y a índices de discriminación inflados, a pesar de que los ítems no discriminan bien entre la mayoría de los sujetos. Proponemos algunas estrategias y comprobaciones para identificar estas situaciones, para facilitar la identificación y eliminación de los ítems inapropiados. Por lo tanto, este artículo pretende promover una actitud crítica, que puede implicar ir en contra de los principios rutinarios establecidos cuando no son apropiados.
PROSUMER CONCEPT: CURRENT STATUS AND POSSIBLE FUTURE DEVELOPMENTS
Authors: LOPEZ FORNIES IGNACIO , ASION  SUÑER LAURA
Published: August 2023

The concept "prosumer" was coined by A. Toffler, a leading sociologist and futurist who made interesting predictions about the role of the consumer in the economy. The term merges the words "producer" and "consumer" to refer to an individual who not only consumes products, but also plays an active role in their production.
RELATIVIZAÇÃO DA NATUREZA SEXUAL NO DELITO DE ESTUPRO DE VULNERÁVEL
Authors: SALOMÃO INGRID , Gonçalves Pereira Ester Gonçalves Pereira , Costa Dos Santos Greiciele Costa Dos Santos , Soares Maciel Lucas , Xavier Figueiredo Cristiane
Published: August 2023

Partindo de uma análise sistemática e teleológica do ordenamento jurídico relacionado ao tema e principalmente da realidade prática, o objetivo geral proposto no artigo é analisar o crime de estupro de vulnerável, mediante a definição conceitual em relação á vulnerabilidade se esta é absoluta ou iuris et de iure ou, em controvérsia , relativa ou iurus  tantum. O legislador na formulação do texto de lei art. 217-A. Determinou de forma direta a presunção vulnerabilidade como absoluta, não deixando margens para a análise de uma presunção relativa dependendo do caso em específico. O debate sobre esse tema tornou-se extremamente necessário nos dias presentes, devido as mudanças sociais, a facilidade de acesso e precoce à informação e, com ela, muitas vezes a maturação sexual precoce dos adolescentes que afetam diretamente a presunção vulnerabilidade. A metodologia para este artigo foi explorada mediante pesquisas bibliográficas, bem como acadêmicos de natureza qualitativa. Partindo de uma análise sistemática e teleológica do ordenamento jurídico afeto ao tema e, principalmente, da realidade prática, o objetivo geral da pesquisa que se propõe através do presente artigo é o de analisar o delito de estupro de vulnerável, exposto no art. 217-A, caput, do código penal.
PAPEL DO PSICÓLOGO JUNTO A CRIANÇAS E ADOLESCENTES VÍTIMAS DE VIOLÊNCIA
Authors: Colares Santos Carina , Dos Anjos Costa Denise
Published: August 2023

A violência sexual contra crianças e adolescentes é um problema de saúde pública, caracterizado por uma das formas mais graves de violação aos direitos humanos. Trata-se de um problema com inúmeras implicações no desenvolvimento cognitivo-comportamental das crianças e adolescentes. Desta forma, o objetivo deste estudo se constitui em discutir os aspectos relacionados à violência sexual praticada contra crianças e adolescentes e o papel de profissionais da área da Psicologia na escuta de argumentações de violência sexual contra crianças e adolescentes têm surgido em todo país. Escuta especializada, depoimento especial assim como perícia psicológica são procedimentos antevistos na legislação brasileira em diversos momentos de uma declaração de violência sexual, enseridos no Sistema de Garantia de Direitos. Enquanto os primeiros procedimentos podem contar com profissionais de outras áreas a perícia psicológica é atribuição exclusiva dos psicólogos. A violência revela-se em suas mais diversas formas, atingindo um número expressivo de pessoas de todas as raças, etnias, condições socioeconômicas, religião ou idade, sem distinção de sexo. Entretanto, as crianças e adolescentes são as vítimas mais frequentes das manifestações de violência. Nesse sentido, objetiva-se identificar as práticas realizadas pela psicologia no contexto de violência sexual infanto-juvenil, em especial, destacar as consequências psicossociais e físicas e averiguar quais estratégias vêm sendo utilizadas pela psicologia para o combate do abuso sexual em crianças e adolescentes. No entanto, ainda existem limitações nos sistemas de justiça que dificultam a oferta de um espaço seguro e acolhedor para que essa escuta possa acontecer. Cabe, portanto, aos profissionais da psicologia buscar estratégias para lidar com tais limitações e ofertar práticas de cuidado.
The kleisin subunit controls the function of C. elegans meiotic cohesins by determining the mode of DNA binding and differential regulation by SCC-2 and WAPL-1
Authors: Castellano-Pozo Maikel , Sioutas Georgios , Barroso Consuelo , Prince Josh P , Lopez-Jimenez Pablo , Davy Joseph , Jaso-Tamame Angel-Luis , Crawley Oliver , Shao Nan , Page Jesus , Martinez-Perez Enrique
Published: August 2023

The cohesin complex plays essential roles in chromosome segregation, 3D genome organisation, and DNA damage repair through its ability to modify DNA topology. In higher eukaryotes, meiotic chromosome function, and therefore fertility, requires cohesin complexes containing meiosis-specific kleisin subunits: REC8 and RAD21L in mammals and REC-8 and COH-3/4 in Caenorhabditis elegans. How these complexes perform the multiple functions of cohesin during meiosis and whether this involves different modes of DNA binding or dynamic association with chromosomes is poorly understood. Combining time-resolved methods of protein removal with live imaging and exploiting the temporospatial organisation of the C. elegans germline, we show that REC-8 complexes provide sister chromatid cohesion (SCC) and DNA repair, while COH-3/4 complexes control higher-order chromosome structure. High-abundance COH-3/4 complexes associate dynamically with individual chromatids in a manner dependent on cohesin loading (SCC-2) and removal (WAPL-1) factors. In contrast, low-abundance REC-8 complexes associate stably with chromosomes, tethering sister chromatids from S-phase until the meiotic divisions. Our results reveal that kleisin identity determines the function of meiotic cohesin by controlling the mode and regulation of cohesin–DNA association, and are consistent with a model in which SCC and DNA looping are performed by variant cohesin complexes that coexist on chromosomes.
Multiple dynamic interactions from basal ganglia direct and indirect pathways mediate action selection
Authors: Li Hao , Jin Xin
Published: August 2023

The basal ganglia are known to be essential for action selection. However, the functional role of basal ganglia direct and indirect pathways in action selection remains unresolved. Here by employing cell-type-specific neuronal recording and manipulation in mice trained in a choice task, we demonstrate that multiple dynamic interactions from the direct and indirect pathways control the action selection. While the direct pathway regulates the behavioral choice in a linear manner, the indirect pathway exerts a nonlinear inverted-U-shaped control over action selection, depending on the inputs and the network state. We propose a new center (direct) - surround (indirect) - context (indirect) “Triple control” functional model of basal ganglia, which can replicate the physiological and behavioral experimental observations that cannot be simply explained by either the traditional “Go/No-go” or more recent “Co-activation” model. These findings have important implications on understanding the basal ganglia circuitry and action selection in health and disease.Using behavior analysis, in vivo electrophysiology, optogenetics and computational modeling in mice, Li and Jin unveiled the neuronal dynamics of basal ganglia direct and indirect pathways underlying action selection, and proposed a new “Triple-control” functional model of basal ganglia.