bluuebunny/crossref_metadata_2025 huggingface dataset:
PSYCHOSOCIAL ASPECT OF THE CRISIS CAUSED BY THE COVID-19 PANDEMIC IN THE REPUBLIC OF NORTH MACEDONIA
Authors:   Faculty of Security – Skopje, Batic Dragana , Krsteska Roza ,   European University - Skopje
Published: August 2023

The World Health Organization in 2020 classified the new Coronavirus SARSCoV2 as a health hazard on a global scale and therefore declared a worldwide pandemic. In order to prevent the spread of the pandemic, many countries, including the Republic of North Macedonia, have taken various measures to limit the spread of the pandemic, such as: closing the borders with other countries, introducing quarantine, selfisolation and social distance, closing educational institutions and jobs and bans on public gathering. The COVID-19 pandemic had a major impact, leaving many people unemployed and leading to a sharp increase in the number of socially vulnerable people. This situation causes fear and uncertainty and still strongly influences people's behavior. In the current situation, the whole developed world, including our country, is facing the same problem: the people massively getting infected with the virus which is a dangerous and still unknown disease, overcrowding of the health system, uncertainty about how long the crisis will last, how it will end, how the state and the individuals will cope with the economic and other losses. In order to reduce the spread of the virus and the disease and to protect the health of the citizens, almost every country in the world introducted preventive measures. These measures significantly change the life of the individual and the community, which additionally causes stress and negative impact on the mental health. Measures of selfisolation, social distance, limited mobility, school from home, work from home and job loss are just some of the changes in the life routine that require adjustment for all residents. It is a crisis that is new, unknown and that affects all countries, continents and people
Rotational Curves of the Milky Way and Andromeda in light of Vacuum Polarization around Eicheon
Authors: Cherkas Sergey L. , Kalashnikov Vladimir L.
Published: August 2023

Eicheon properties are discussed. It is shown that the eicheon surface allows setting a boundary condition for the vacuum polarization and obtaining a solution describing the dark matter tail in the Milky Way. That is, the dark matter in the Milky Way is explained as the F-type of vacuum polarization, which could be treated as dark radiation. The model presented is spherically symmetric, but a surface density of a baryonic galaxy disk is taken into account approximately by smearing the disk over a sphere. This allows the reproduction of the large distance shape of the Milky Way rotational curve. Andromeda's rotational curves are also discussed.
Observing Material Properties in Composite Structures from Actual Rotations
Authors: Emadi Seyyedbehrad , Sun Yuan , Lozano-Galant Jose A. , Turmo Jose
Published: August 2023

Shear deflection effects are traditionally neglected in most structural system identification methods. Unfortunately, this assumption might lead to significant errors in some structures, like deep beams. Although some inverse analysis methods based on the stiffness matrix method including shear deformation effects have been presented in the literature, none of these methods is able to deal with actual rotations in their formulations. Recently, the observability techniques, one of the first methods for the inverse analysis of structures included the shear effects into the system of equations. In this approach, the effects of shear rotation are neglected. When actual rotations on site are used to estimate the mechanical properties in the inverse analysis, it can result in serious errors in the observed properties. This characteristic might be especially problematic in structures such as deep beams where only rotations can be measured. To solve this problem and increase the observability techniques' applicability, this paper proposes a new approach to include shear rotations into the inverse analysis by observability techniques. This modification is based on the introduction of a new iterative process. To illustrate the applicability and potential of the proposed method, the inverse analysis of several examples of growing complexity is presented.
Identify Novel Targeting Sites of Calcineurin and CaMKII in Human Cav3.2 T-type Calcium Channel
Authors: Chang Yu-Wang , Chen Yong-Cyuan , Chen Chien-Chang
Published: August 2023

The Cav3.2 T-type calcium channel is implicated in various pathological conditions, including cardiac hypertrophy, epilepsy, autism, and chronic pain. Phosphorylation of Cav3.2 by multiple kinases plays a pivotal role in regulating its calcium channel function. The calcium/calmodulin-dependent serine/threonine phosphatase, calcineurin, interacts physically with Cav3.2 and modulates its activity. However, it remains unclear whether calcineurin dephosphorylates Cav3.2, the specific spatial regions on Cav3.2 involved, and the extent of the quantitative impact. In this study, we elucidated the serine/threonine residues on Cav3.2 targeted by calcineurin using quantitative mass spectrometry. We identified six serine residues in the N-terminus, II-III loop, and C-terminus of Cav3.2 that were dephosphorylated by calcineurin. Notably, a higher level of dephosphorylation was observed in the Cav3.2 C-terminus, where calcineurin binds to this channel. Additionally, a previously known CaMKII-phosphorylated site, S1198, was found to be dephosphorylated by calcineurin. Furthermore, we also discovered that a novel CaMKII-phosphorylated site, S2137, underwent dephosphorylation by calcineurin. In CAD cells, a mouse central nervous system cell line, membrane depolarization led to an increase in the phosphorylation of endogenous Cav3.2 at S2137. Mutation of S2137 affected the calcium channel function of Cav3.2. Our findings advance the understanding of Cav3.2 regulation not only through kinase phosphorylation but also via calcineurin phosphatase dephosphorylation.
Cyclic Neutropenia Mimicking Crohn’s Disease: Two Case Reports and a Narrative Review
Authors: Guarino Alessia Dalila , Luglio Gaetano , Imperatore Nicola , Cerciello Giuseppe , Pugliese Novella , Castiglione Fabiana , Tropeano Francesca Paola , Testa Anna , Olmo Oriana , Rispo Antonio
Published: August 2023

Cyclic neutropenia is a rare hematological condition characterized by periodic fluctuations in neutrophil counts, with a 21-day periodicity. Clinical presentation varies from mild to severe forms of the disease, with the onset of recurrent fever, painful oral ulcers, recurrent bacterial infections, peritonitis and septic shock. The availability of granulocyte colony-stimulating factor (G-CSF) has revolutionized the management and natural history of this disease, regulating the proliferation, differentiation and maturation of the progenitor cells, reducing the duration of neutropenia. Inflammatory bowel disease (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC), is a group of chronic pathologies with involvement of the gastrointestinal tract. Symptoms include diarrhea, abdominal pain, fever, weight loss and extraintestinal manifestations (EIMs). In recent years, the focus of IBD therapy, including conventional therapies and biological therapies, has moved from treatment of symptoms to "deep remission" of the disease. The association between cyclic neutropenia and CD is rarely reported in the literature. Here, we describe two case reports of patients who underwent surgery because of diagnosis of complicated CD. After surgery, because of persistent neutropenia, the hematologist consultant confirmed suspicions of cyclic neutropenia and therapy with G-CSF was started with benefits, underlining the crucial importance of proper differential diagnosis.
Analysing Wilson’s and Goldberger’s Central Terminals: Theoretical Redesign of a Novel Central Terminal for Precordial Leads
Authors: Bermejo Valdés Alejandro Jesús
Published: August 2023

This study delves into the foundational aspects of electrocardiographic (ECG) lead systems, specifically focusing on Einthoven’s Triangle and Wilson’s Central Terminal. We introduce the innovative concept of a Precordial Central Terminal, a strategic arrangement of thoracic electrodes that establishes two Einthoven’s triangles within the horizontal plane, in accordance with physical-mathematical principles. Furthermore, we meticulously scrutinize Goldberger’s contributions to the field of ECG, particularly augmented leads, which shed light on the development of our theory. Additionally, we propose the implementation of a novel standardized electrocardiograph, characterized by its use of exclusively “precordial” electrodes, yet capable of providing a comprehensive three-dimensional perspective of cardiac electrical activity. By amalgamating theoretical underpinnings with empirical experimentation, our study lays the groundwork for future investigations, including the experimental validation of our innovative Precordial Terminal. This validation holds the promise of yielding substantial advancements in the realm of clinical electrocardiography.
Using TAM and Maslow’s Needs Theory to Evaluate the Intention of Adoption of Home-Based Intelligent Exercise System: The Example of Golf Croquet
Authors: Zhou Yu-Li , Chen Chia-Li , Chang Shih-Jui , Wu And Bo-Sheng
Published: August 2023

In 2020 the world experienced the threat of the COVID-19 epidemic, as seniors and chronic disease patients typically try to reduce their exercise and social activities to avoid increasing the risk of infection, which could lead to increased loneliness and even many diseases. This research combining golf croquet games with AIoT companion robots constructs a home-based intelligent exercise system thus uses the Technology Acceptance Model (TAM), deduces users’ intention to use this system based on perceived usefulness and perceived ease of use, and adds the needs of love and belonging, esteem, cognitive, aesthetic, and self-actualization in Maslow’s needs theory to conduct system needs analysis. The analysis results show that participants have a high level of acceptance of this system, believing that it is easy to learn and operate, can increase interaction with others, also found that this system can improve self-confirmation, satisfying the third for knowledge, feeling happy, and self-actualization needs are easier to fulfill. In the future, we shall collect and record the seniors in the process of use, so as to find out their health problems as soon as possible, expand their daily life through this exercise, and achieve the goal of happy living and health care.
Phylogenetic, Sequencing, and Mutations Analysis of the SARS-CoV-2 Omicron (BA.1) and Sub-variants (BA.1.1, BA.2) during the Fifth Wave of the Pandemic in the Iraqi Kurdistan Region
Authors: Taher Sherzad Majeed , Abdo Jassim Mohammed , Merza Muayad Aghali
Published: August 2023

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first identified in humans in Wuhan City at the end of December 2019. Since then, it has spread to all the countries. Therefore, global interest has been focused on discovering treatments and developing successful vaccines. This study sequenced the complete genome of the SARS-COV-2 Omicron Omicron (BA.1) and sub-variants (BA.1.1, BA.2), which were isolated from 40 individuals in Duhok, Iraq. Ninety-five different mutations were identified when the complete genome of the SARS-COV-2 virus discovered in Wuhan, China (accession number: NC 045512.2) was matched to the virus sequence using sequencing technology (Illumina, USA). Sequence analysis revealed 38 mutations in spike glycoprotein (S), 30 of which were found in ORF1a. Additionally, 11 mutations were found in ORF1b, and 7,3,2,1 mutations were found in Nucleocapsid (N), membrane protein (M), Open Reading Frames 6 (ORF6), Open Reading Frames 9 (ORF9), and Envelope (E) genes, respectively. Phylogenetic analysis and transmission further confirmed that the isolates found in Iraq had distinct infection origins and were closely related to those from other countries and states. According to the findings of this study, a new vaccine can be developed based on identifying new Omicron variant mutations and sub-variants such as BA.2, which were identified for the first time in Iraq.
A GAN-based Augmentation Scheme for SAR Deceptive Jamming Templates with Shadows
Authors: Lang Shinan , Li Guiqiang , Liu Yi , Lu Wei , Zhang Qunying , Chao Kun
Published: August 2023

To realize fast and effective synthetic aperture radar (SAR) deception jamming, a high-quality SAR deception jamming template library can be generated by performing sample augmentation on SAR deception jamming templates. However, current sample augmentation schemes of SAR deception jamming templates face certain problems. First, the authenticity of templates is low due to the lack of speckle noise. Second, the generated templates have low similarity to the target and shadow areas of the input templates. To solve these problems, this study proposes a sample augmentation scheme based on generative adversarial networks, which can generate a high-quality library of SAR deception jamming templates with shadows. The proposed scheme solves the two aforementioned problems from the following aspects. First, the influence of the speckle noise is considered in the network to avoid the problem of reduced authenticity in generated images. Second, a channel attention mechanism module is used to improve the network's learning ability of shadow features, which improves the similarity between the generated template and the shadow area in the input template. Finally, the proposed scheme and the SinGAN scheme are compared regarding the equivalent numbers of looks and the structural similarity between the target and shadow in the sample augmentation results. The comparison results demonstrate that, compared to the templates generated by the SinGAN scheme, those generated by the proposed scheme have targets and shadow features similar to those of the original image, and can incorporate speckle noise characteristics, resulting in higher authenticity, which helps to achieve fast and effective SAR deception jamming.
Clinical and Paraclinical Characteristics of Endobronchic Pulmonary Squamous Carcinoma- Brief Review
Authors: Radu Șerban Matache , Camelia Stanciu-Gavan , Daniel Pantile , Adrian Mihail Iordache , Andreea Octavia Bejgăneanu , Crenguta Sorina Șerboiu , Alexandra Floriana Nemes
Published: August 2023

Background – Endobronchial squamous cell carcinoma is one of the most common types of tumors with such a location. Patients often present in advanced stages of the disease, which leads to a targeted therapeutic attitude of pneumonectomy, most of the time. Practicing a lung parenchyma-preserving surgery led us to do this review. Material and Methods - We used three search platforms SCIENCE, MEDLINE and PubMed, in order to identify studies presenting case reports, studies and reviews on endobronchial squamous cell carcinoma. We identified clinical and paraclinical features of endobronchial squamous cell carcinoma. All selected articles were in English and contained clinical criteria of endobronchial squamous cell carcinoma, autofluorescence bronchoscopy in endobronchial squamous cell carcinoma, imaging features of endobronchial squamous cell carcinoma, blood tumor markers specific for lung squamous cell carcinoma, histopathological features of endobronchial squamous cell carcinoma. Results - 73 articles were analyzed, from which 47 articles were selected as bibliographic references. We have presented the criteria found for endobronchial squamous cell carcinoma in order to highlight the main characteristics and high reliability technologies for the detection of this type of cancer. Conclusions – The current literature review highlights the clinical and paraclinical characteristics of endobronchial squamous cell carcinoma. It aims to open new horizons for research and early detection, frequent practice of lung parenchymal preservation surgery.
Follow‐up of Non‐Palpable Incidentalomas >1CM: Does Growth Rate Allow Distinguish between Malignant and Non‐malignant Lesions?
Authors: Bertolotto Michele , Campo Irene , Freeman Simon , Lotti Francesco , Huang Dean Y , Rocher Laurence , Dell'Atti Lucio , Valentino Massimo , Yuan Jia Cheng , Visalli Gianluca , Pavlica Pietro , Sidhu Paul S , Derchi Lorenzo
Published: August 2023

Increasingly small, non-palpable testicular incidentalomas <1cm are discovered in the clinical practice. The ESUR Scrotal and Penile Imaging Working Group suggests active surveillance with US, and surgery only for nodules that grow. This approach, however, requires validation.
A consecutive series of 127 incidentalomas were initially followed-up and operated if they were growing (n=28), or because of preference of the patient and of the referring urologist (n=11). For the lesions that were growing specific growth rate (SGR) and doubling time (DT) were calculated assuming an exponential grow. Also, the velocity of increase of the average diameter (∆Dav) and of the maximum diameter (∆Dmax) were calculated. Of the 127 nodules which were initially followed-up, 6 disappeared, 8 reduced in size, 85 were stable, and 28 increased in size. All 18 malignant tumours, 8/9 benign tumours, and 2/12 surgically proved non-neoplastic lesions were growing. The best cut-off values of the growth indicators to differentiate between malignant and non-malignant histology were 3.47x10-3 %volume/day, ≤179 days, >10x10-3 mm/day, and >5x10-3 mm/day for SGR, DT, ∆Dmax, ∆Dav, respectively.
A conservative approach of non-growing small incidentalomas is safe. Malignant and non-malignant small incidentalomas can be effectively differentiated based on growing parameters, even though superimposition exists.
Significance of Plasma Irisin, Adiponectin and Retinol Binding Protein-4 Levels as Biomarkers for Obstructive Sleep Apnea Syndrome Severity
Authors: Fazlıoglu Nevin , Uysal Pelin , Durmuş Sinem , YURT SİBEL , Gelisgen Remise , Uzun Hafize
Published: August 2023

Objective: Obstructive sleep apnea syndrome (OSAS) is a common sleep disorder that is caused by the reduction or cessation of airflow in the upper airway. Irisin, retinol-binding protein-4 (RBP-4), and adiponectin are the three significant factors in the metabolic process of the human body. The objective of this study was to investigate whether plasma irisin, RBP-4, and adiponectin levels are associated with the severity of OSAS. Methods: According to inclusion and exclusion criteria, 125 patients with OSAS and 46 healthy, gender matched controls were included to the study. The patients were classified according to the apnea hypopnea index (AHI) as 14 mild cases (5<AHI<15), 23 moderate OSAS cases (15<AHI<30) and 88 severe OSAS cases (AHI>30). The plasma irisin, RBP-4 and adiponectin levels were measured and compared between groups. Results: RBP-4 levels were higher in severe OSAS compared to moderate (p<0.05) and mild (p<0.001) OSAS groups, irisin levels were significantly lower compared to moderate (p<0.05) and mild (p<0.001) OSAS groups. There was a negative correlation between irisin and RBP-4 (r=-0.379; p<0.001) and AHI (r=-0.834; p<0.001) and a positive correlation with minimum oxygen saturation (MOS) (r=0.341; p<0.001) in the patient group. In the patient group, there was a negative correlation between adiponectin and BMI (r=-0.682; p<0.001), RBP-4 (r=-0.292; p<0.01) and AHI (r=-0.179; p<0.05) and a positive correlation with MOS (r=0.397; p<0.001). In the patient group, there was a positive correlation between RBP-4 and BMI (r=0.406; p<0.001) and AHI (r=0.473; p<0.001) and a negative correlation with MOS (r=-0.805; p<0.001). As a predictor of OSAS, adiponectin showed the highest specificity (84.8%) and RBP-4 the highest sensitivity (92.0%). Conclusion: The results of the present study demonstrated that the severity of OSAS causes more metabolic problems, including decreased plasma irisin and adiponectin levels and an increased plasma RBP-4 level. As a result, patients with an AHI score greater than thirty should be closely monitored for metabolic and cardiovascular abnormalities.
Anomalous Interactions of Airy Solitons Modulated by Fundamental Gaussian Beam and Fourth-Order Diffraction
Authors: Zhao Wenwen , Ge Lijuan , Shen Ming
Published: August 2023

We investigate numerically the interactions of in-phase Airy beams modulated by a fundamental Gaussian beam and fourth-order diffraction in Kerr nonlinear media. Directly numerical simulations show that normal (anomalous) fourth-order diffractions and in-phase (out-of-phase) Gaussian beam affect the interactions of solitons generated from Airy beams in unique manners. Different from previous results that interactions between in-phase (out-of-phase) conventional beams are always attractive (repulsive), many anomalous interactions of Airy beams are obtained. Stable bound states of breathing Airy soliton pairs can be formed with the help of fourth-order diffraction and fundamental Gaussian beam.
Complete Mitochondrial Genome Sequencing of the Calanoid Copepod Bestiolina similis (Sewell, 1914) from the Chennai Coast
Authors: Kandhasamy Sivakumar , Nawaz MD Anwar , Saboor Abdus
Published: August 2023

Copepods are the most abundant metazoans on Earth, exhibit remarkable species diversity and global distribution. Accurate species identification of copepods presents a challenge due to their cryptic nature, necessitating meticulous examination and differentiation. To address this challenge, innovative approaches utilizing molecular markers have emerged, enabling more reliable and precise species identification. Mitochondrial genes, which are characterized by high variability, have proven invaluable in uncovering taxonomically significant variations among copepod species. In this study, we present the first complete mitochondrial genome analysis of the marine calanoid copepod Bestiolina similis (Sewell, 1914). Recent investigations employing whole mitochondrial genome-based phylogenetic analyses have generated considerable interest in exploring the deep branching patterns of arthropods. The complete mitochondrial genome of B. similis spans 23,704 base pairs and includes 13 protein-coding genes and 20 transfer RNA genes. The nucleotide composition of the mitochondrial genome is characterized by 43.42% adenine, 43.22% thymine, 6.48% guanine, and 6.88% cytosine. Maximum likelihood-based phylogenetic analysis of the mitochondrial genome were constructed of the available copepod species. Mitochondrial ge-nome-based phylogenies often reveal intriguing and distinctive topologies compared to traditional phylogenetic approaches. However, the sequencing of copepod mitochondrial genomes, particularly within the calanoid copepods remains limited. Therefore, this study aims to construct a phylogenetic tree based on the extracted mitochondrial genome, incorporating available data, to enhance our understanding of the evolutionary relationships among calanoid copepods.
Prediction of intrauterine infection in prelabor rupture of membranes and preterm birth
Authors:   Pirogov Russian National Research Medical University, Moscow, Russian Federation, Anankina A.A. , Shalina R.I. ,   Pirogov Russian National Research Medical University, Moscow, Russian Federation, Lebedev E.V. ,   Pirogov Russian National Research Medical University, Moscow, Russian Federation, Spiridonov D.S. ,   Pirogov Russian National Research Medical University, Moscow, Russian Federation, Titov V.Yu. ,   Pirogov Russian National Research Medical University, Moscow, Russian Federation
Published: August 2023

Objective. To study significant risk factors for predicting intrauterine infection (IUI) in patients with prelabor upture of membranes (PROM) and threatened preterm birth (PB). Patients and methods. A retrospective study was conducted, including the analysis of prenatal records, labor and delivery records, and neonatal development (n = 125). Labor and delivery records were selected considering the diagnoses of preterm birth” and “prelabor rupture of membranes”. Two patient groups were identified: group 1 (n = 59) consisted of patients diagnosed with IUI, group 2 (n = 66) – patients without diagnosis of IUI. Medical records of pregnant women and the results of clinical, laboratory, and instrumental examinations during pregnancy and at the time of hospitalization were analyzed. A comparative assessment of perinatal outcomes was performed. Results. Statistically significant risk factors for IUI regardless of gestational age included hereditary thrombophilia (OR: 2.837; 95% CI: 1.057–7.618), history of ≥2 pregnancies (OR: 2.494; 95% CI: 1.093–5.690), PB, and recurrent miscarriage (OR: 2.392; 95% CI: 1.019–5.615). Among pregnancy and delivery complications, the following were important in predicting IUI: the presence of isthmic-cervical insufficiency (ICI) (OR: 2.698; 95% CI: 1.058–6.878), the duration of waterless period (p = 0.037), gestational age at the onset of membrane rupture (p < 0.001) and delivery (p < 0.001). Conclusion. In case of expectant management, the prognostic model should be used to predict IUI in patients at risk of PB and PROM. Based on the calculation of the adjusted odds ratio, we identified the factors that have a statistically significant effect on IUI development, irrespective of other predictors, with a sensitivity of 86.7% and specificity of 92.6%. Key words: vaginal microbiota, intrauterine infection, intrauterine pneumonia, intraamniotic infection, prelabor rupture of membranes, preterm birth, chorioamnionitis
Myomectomy during cesarean delivery: clinical features and outcomes
Authors:   Novosibirsk State Medical University, Novosibirsk, Russian Federation, Marinkin I.O. , Khachatryan S.M. ,   State Novosibirsk Regional Clinical Hospital, Novosibirsk, Russian Federation, Babichev V.K. ,   Novosibirsk State Medical University, Novosibirsk, Russian Federation, Volchek A.V. ,   Novosibirsk State Medical University, Novosibirsk, Russian Federation,   State Novosibirsk Regional Clinical Hospital, Novosibirsk, Russian Federation, Kozlov S.S. ,   State Novosibirsk Regional Clinical Hospital, Novosibirsk, Russian Federation, Piven L.A. ,   Novosibirsk State Medical University, Novosibirsk, Russian Federation,   State Novosibirsk Regional Clinical Hospital, Novosibirsk, Russian Federation, Aidagulova S.V. ,   Novosibirsk State Medical University, Novosibirsk, Russian Federation
Published: August 2023

Objective. To study the clinical features and outcomes of myomectomy during cesarean delivery, including in the effect of progestogens. Patients and methods. The study enrolled 61 patients who gave birth by cesarean section. Among them there were 41 women with multiple uterine fibroids and/or a node diameter >50 mm. The patients were divided into three groups: group 1 included 22 women who took progestogens in the first and second trimesters of pregnancy; group 2 consisted of 19 women who did not receive hormone therapy; the control group included 20 women without uterine fibroids. Results. The duration of operation did not differ cumulatively between three patient groups, including the control group. A strong positive correlation between operation duration and blood loss was found in patients with uterine fibroids. The length of stay was determined both by myomectomy performed during cesarean section and by progestogen intake during the current pregnancy. The location of myomatous nodes had an impact on discharge day when comparing patients with fibroid types 4 and 5 according to FIGO. The length of stay was statistically significantly longer in fibroid type 4 (intramural). Conclusion. Progestogen administration did not directly affect the size of myomatous nodes removed during delivery and the duration of postoperative hospital stay in patients who underwent myomectomy, while intraoperative blood loss was 100 mL greater than in the control group without myomectomy. Key words: discharge day, operation duration, cesarean section, blood loss, myomectomy during delivery, progestogens
Outcomes of ovarian endometrioma aspiration before ultra-long agonist protocol during ICSI cycles: a multicenter randomized clinical trial
Authors:   Tanta University, Tanta, Egypt, Dawood A. , Shaaban A. ,   Al-Azhar University, Cairo, Egypt, Omar M. ,   Tanta University, Tanta, Egypt
Published: August 2023

Ovarian endometriomas negatively affect the outcomes of intracytoplasmic sperm injection (ICSI). Numerous procedures and medications have been used to reduce the negative impact of endometriomas on ICSI outcomes. Endometrioma aspiration is one such procedure with controversial results. Objective. To evaluate the therapeutic efficacy and reproductive outcomes of endometrioma aspiration before starting a long ICSI protocol with agonists. Patients and methods. This multicenter randomized clinical trial enrolled 84 women with small ovarian endometrioma (3–5 cm) previously diagnosed by ultrasound in five fertility centers in Egypt from July 2017 to June 2022. Participants were randomly allocated into two groups (n = 42/each). Group I underwent endometrioma aspiration prior to the ultra-long agonist protocol, and group II had only the ultra-long agonist protocol. The rate of clinical pregnancy, cycle cancellation, ovarian hyperstimulation syndrome, endometrioma recurrence, and pelvic infections were measured. Results. Endometrioma size decreased significantly after aspiration. The total dose of gonadotropins and the duration of stimulation were statistically significantly lower in group I compared to the control group (p < 0.001 for both groups). The total number of retrieved and mature oocytes as well as the number of developed embryos were statistically significantly higher in group I than in the control group (p < 0.001 for both groups). However, there were no statistically significant differences between the groups regarding embryo quality and the rates of pregnancy, miscarriage, and live births. Conclusion. Aspiration of small ovarian endometriomas before the ultra-long protocol in ICSI cycles reduced gonadotropin doses, shortened the stimulation period, and increased the number of retrieved oocytes. Nevertheless, there were no significant differences regarding embryo quality and pregnancy rates between the two groups. Key words: endometriosis, ICSI, ovulation, pregnancy
Dequalinium chloride in the treatment of vaginal infections
Authors:   Kuban State Medical University, Kutsenko I.I. , Borovikov I.O. ,   Kuban State Medical University, Kravtsova E.I. ,   Kuban State Medical University, Bulgakova V.P. ,   Kuban State Medical University, Borovikova O.I. ,   Kuban State Medical University, Cheremnykh R.V. ,   Kuban State Medical University
Published: August 2023

The most common inflammatory and infectious diseases of the lower genital tract include bacterial vaginosis (BV), vulvovaginal candidiasis (VVC), aerobic vaginitis, and mixed infections. Standard modern therapies show acceptable but short-term efficacy in most cases, and high recurrence rates and increased antimicrobial resistance remain an unresolved issue. Moreover, vaginal infections are associated with different adverse outcomes both in terms of higher incidence of infertility among couples and gestational complications, having a serious impact on patients’ quality of life. The determination of appropriate management tactics for these women, especially in mixed infections, is quite a challenge for clinicians. This metaanalysis evaluates the efficacy of topical therapy with antimicrobial antiseptics containing dequalinium chloride for various types of vaginal infections. Objective. To analyze the clinical and microbiological efficacy and safety of dequalinium chloride in the treatment of vaginal infections of different etiologies. Materials and methods. A review of selected scientific publications over the past 40 years on the use of dequalinium chloride in the treatment of vaginal infections with assessing the efficacy and safety of its topical use in women was conducted. A total of 4,783 patients (from 26 studies) were included. Results. Dequalinium chloride is an antimicrobial antiseptic agent with broad bactericidal and fungicidal activity and low systemic absorption after vaginal administration. At the same time, dequalinium chloride has similar clinical efficacy to clindamycin when used topically in the treatment of bacterial vaginosis, and its broad antimicrobial activity appears to be most suitable for the treatment of mixed vaginal infections. In addition, the development of microbial resistance to this drug is unlikely due to its pluripotent mechanism of action and local application. Conclusion. The analysis showed that the current formulation of dequalinium chloride (10 mg vaginal tablets) as 6-day therapy with its broad spectrum of antimicrobial activity and good tolerability offers a safe and effective option for empiric therapy of various vaginal infections in daily practice. Key words: vaginal infections, bacterial vaginosis, vulvovaginal candidiasis, anaerobic vaginitis, dequalinium chloride
Descriptors of oocyte competence and outcomes of in vitro fertilization programs
Authors:   Siberian State Medical University, Tomsk, Russian Federation, Petrov I.A. , Samoilova Iu.G. ,   Siberian State Medical University, Tomsk, Russian Federation, Sidorenkova K.A. ,   Siberian State Medical University, Tomsk, Russian Federation, Prozorova A.V. ,   Siberian State Medical University, Tomsk, Russian Federation, Timofeeva O.S. ,   Siberian State Medical University, Tomsk, Russian Federation, Kudlay D.A. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation,   National Research Center “Institute of Immunology”, Moscow, Russian Federation
Published: August 2023

This review presents data on estradiol, progesterone, and leptin as important hormones in reproductive medicine. The effects of these hormones in peripheral blood and follicular fluid on the outcomes of assisted reproductive technology programs are considered. Data on experimental studies and prospects for their use in clinical practice are presented. Given the established fact that the composition of follicular fluid has an influence on the quality of oocytes, estradiol, progesterone, and leptin contained in follicular fluid can serve as descriptors of embryo competence. There are conflicting results in the literature regarding the effect of these hormones on the outcomes of in vitro fertilization programs. Conclusion. The role of intrafollicular estradiol, progesterone, and leptin on the outcomes of in vitro fertilization programs need to be further investigated. Key words: follicular fluid, estradiol, progesterone, leptin, in vitro fertilization, embryo competence
COVID-19, thromboinflammation and hemostatic dysregulation in pregnant women
Authors:   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Bitsadze V.O. , Gashimova N.R. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Grigoryeva K.N. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Khizroeva D.Kh. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Tretyakova M.V. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Degtyareva N.D. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Kvaratskheliia M.V. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Yakubova F.E. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Nakaidze I.K. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Gris J-Ch. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Elalami I. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Slukhanchuk E.V. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, A.D.Makatsariya A.D. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation
Published: August 2023

During pregnancy, significant changes occur in pro- and anticoagulant links of hemostasis, which creates the preconditions for the development of hypercoagulation. SARS-CoV-2 coronavirus infection itself contributes to the development of endotheliopathy in various organs and tissues, leading to thrombotic microangiopathy. Coagulopathy in COVID-19 is a model of immunothrombosis supported by several mechanisms. Therefore, the effect of COVID-19 on the course of pregnancy is an important medical and social problem, since thromboinflammation and endotheliopathies formed against COVID-19 can cause placentaassociated complications and microthromboses. Conclusion. Pregnant patients with high concentrations of D-dimer and inflammatory markers should be constantly monitored by an obstetrician-gynecologist and, in the absence of contraindications to anticoagulants, should receive prophylactic doses of low-molecular-weight heparin. Key words: COVID-19, hemostasis, thrombotic microangiopathy, hyperinflammation, ADAMTS13/vWF
Acute Irreducible Rotational Patellar Dislocation with Patellar Tendon Rupture
Authors: Askari Alireza , Jabalameli Mahmoud , Arasteh Peyman , Kassir Hassan
Published: August 2023

Case:

In this report, we present a case of acute patellar dislocation with both vertical and longitudinal rotation of the patella. As a result of rotation in the longitudinal axis, the articular surface of the patella faced outward, and the dorsal surface faced the femoral condyle. The patient underwent open reduction. One year after open reduction and soft-tissue repair, the patient had acceptable knee function and no knee pain.

Conclusion:

This case shows how similar cases may be treated with an open reduction to properly address the patellar dislocation.
Revision Total Hip Arthroplasty Using a Tibial Cone and Impaction Grafting for Severe Femoral Bone Loss
Authors: Ramos Michael S. , Rullan-Oliver Pedro , Pasqualini Ignacio , Piuzzi Nicolas S. , Molloy Robert M.
Published: August 2023

Case:

An 84-year-old woman presented 6 years after revision total hip arthroplasty (rTHA) with worsening hip pain and a Paprosky classification IIIB femoral defect. rTHA was performed using a proximal femur replacement. Given her osteoporosis and poor bone stock, a tibial cone and impaction grafting (IG) were used for megaprosthesis fixation. At the 33-month follow-up, the patient was pain-free and radiographs demonstrated a well-fixed implant.

Conclusion:

In the setting of massive defects of poor-quality bone, novel use of a tibial cone and IG can be implemented to achieve implant fixation and maximize patient outcomes.
Evaluation and Treatment of Primary Spinal Epidural Lymphoma Presenting as Acute Myelopathy in a Young Adult
Authors: Cowley R. Adams , Carroll Austin H. , Pasko Kory B.D. , Rubenstein Eric , Tagouri Yahia M. , Weiner David
Published: August 2023

Case:

Primary spinal epidural lymphoma (PSEL) presenting as myelopathy is extremely rare, particularly within young, healthy adults. This case report describes a 26-year-old man presenting with progressive thoracic myelopathy. Magnetic resonance imaging revealed spinal epidural masses spanning T5-T10 and T12-L2 with multilevel cord compression and edema. After evaluation, the patient underwent emergent posterior decompression to prevent progressive neurological decline. Histology was consistent with diffuse large B-cell lymphoma, germinal center type. At 3 months postoperatively, the patient regained full neurologic function.

Conclusion:

Although rare, PSELs should be considered in patients presenting with myelopathy to facilitate timely diagnosis and treatment.
Total Wrist Arthroplasty as a Motion-Sparing Option for Distal Radius Malunion in a Patient of Advanced Age
Authors: Cooke Hayden L. , Schaeffer Christine V. , Gabig Andrew M. , Karzon Anthony , Savani Ujjawal , Gottschalk Michael B. , Wagner Eric R.
Published: August 2023

Case:

A 62-year-old woman presented with wrist pain secondary to a distal radius fracture malunion 4 months after a fall onto an outstretched hand. She was not an ideal candidate for osteotomy and bone graft because of the degree of displacement and osteoporosis, so after nonoperative treatment was unsuccessful, she was offered total wrist arthroplasty (TWA) or arthrodesis and opted for TWA.

Conclusion:

At 14-month follow-up, the patient reported significant improvement in her pain and function. The current generation of TWA implants may allow use in the management of symptomatic distal radius malunions in older, low-demand patients.
Removal of a Bent Tibial Intramedullary Nail Through Osteotomy and Partial Sectioning
Authors: Arif Haad , Molina Steven , LeBrun Christopher
Published: August 2023

Case:

An 18-year-old male patient presented with a closed fracture of the left tibia and fibula and a bent intramedullary nail after a repeat motorcycle accident. The patient was 5 weeks postoperative from intramedullary nailing of a closed left tibia fracture. The site of angulation of the tibial nail was noted to be more proximal than the fracture site. Partial sectioning of the nail through an osteotomy permitted the removal of the nail and revision tibial nailing.

Conclusion:

This is the first reported use of an osteotomy and partial sectioning during the extraction of a bent tibial intramedullary nail.
Plan de negocios de exportación de galletas, barras y cocoa
Authors:   , Espinoza Berrospi Rosario Dennis , Grimaldo Lozano Cristhian Harol , Palomino Pizarro Sandra Lucero , Salgado Pineda Joyce Yamile
Published: August 2023

El presente plan evaluara la viabilidad de comercializar productos al extranjero, teniendo como inicio de operaciones al país de México, el cual fue seleccionado a través de una serie de filtros como porcentaje de pobreza, producto bruto interno (PBI), cantidad de población con anemia, hábitos de consumo. La importancia de desarrollar esta gama de productos radica en satisfacer la demanda de personas con deficiencia de hierro en el país de destino, con el objetivo de posicionar a largo plazo nuestros productos, dando a conocer las propiedades nutritivas de la harina de sangre bovino, considerando que es un alimento alto en hierro y tomando como referencia las personas con deficiencia de hierro. Se tiene como referencia que el 57% de mexicanos padece de anemia, las cuales posee siete segmentos socioeconómicos que se dividen en AB, C+, C, C-, D+, D, E y los grupos de edades de 3 años a más, de las cuales nuestra gama de productos estará posicionada en cada segmento. Abarcando el 1% del mercado con anemia en el primer año, el cual ira aumentando paulatinamente cada año. Principalmente mostramos sobre el inicio del negocio detallando los puntos importantes ya también para determinar la localización del negocio, como siguiente punto presentaremos sobre los perfiles del consumidor, competencia entre otros aspectos que determinaron la elección de nuestro mercado destino, como segundo punto veremos las características de nuestro producto, la propuesta de valor que ofrece y también realizaremos un análisis de determinación de posibles clientes, a su vez analizando la oferta, demanda y competitividad que se tiene en el mercado destino como tercer lugar veremos distintos tipos de estrategias de ingreso en el mercado destino.
Plan de negocio para la comercialización de comida BARF saludable de perro
Authors:   , Farfán Utrilla Angela Juliana , Castro Lozada Neri Ester , Samán Matias Nora Zulema , Flores Campos Luis Fernando , Mandujano Huamani Katherine Cinthia
Published: August 2023

Con nuestra investigación de mercado notamos que se tiene una necesidad por adquirir alimentos para mascotas naturales en contenedores que preserven las bondades e estos, por lo cual presentamos nuestros productos de alimentos para mascotas naturales en bolsas trasminadas que conservan y preservan las nutrientes de los alimentos, nos enfocaremos en público masculino y femenino 20 a 50 años de Lima Moderna, nuestro local estará en el distrito de Barranco. Nuestra misión de la empresa es que “Somos una empresa eco amigable dedicada a la comercialización de comida saludable para perros con condiciones de salud especiales” y la visión “Ser reconocida como una empresa líder a nivel nacional en la comercializadora de comida saludable para perros con condiciones de salud especiales”. Manejaremos una estrategia de diferenciación que nos va a permitir con la finalidad de lograr llegar más rápido a nuestros consumidores; manejaremos un alto control de calidad y un servicio de postventa, de esta forma podremos impulsar la venta de nuestro producto logrando ganar una estabilidad en la empresa.
Synthesis and characterization of ZnO Nanoparticles using Cd and Sn as dopants and for photocatalytic degradation of Eosin yellow and Direct blue15 under UV light irradiation
Authors: Jayasankari S. , Pramothkumar A , Mani P.
Published: August 2023

In the present report, the facile co-precipitation technique was used to synthesis undoped ZnO NPs, Cd-doped and Sn-doped ZnO NPs. The XRD patterns shows that the all-synthesized samples were confirmed the hexagonal crystal structure of ZnO NPs, which reveals that, there were no impurities in the doped materials. The FT-IR studies confirms the phase formation of ZnO and also shows the confirms the functional groups present in the synthesized samples. From UV-DRS, the band gap of pure ZnO NPs is decreased from 3.38 eV to 3.21 eV by adding the dopant Cd. Whereas, the addition of Sn decreases the band gap to 3.30 eV. From PL spectrum, the near band emission (393 nm) and blue emission (451 and 468 nm) were observed. SEM images show the considerable change in morphology from the flakes like morphologies to non-uniform surface of nanostructured morphology and homogonous spherical shaped nanostructured morphology when Cd and Sn are added as dopants. The photocatalytic activity of ZnO NPs, Cd-doped and Sn-doped ZnO NPs were analysed by the degradation of Eosin Yellow (EY) and Direct Blue 15 (DB-15) under UV light irradiation. The prepared Cd-doped ZnO NPs shows a high photocatalytic activity compared with pure ZnO NPs and Sn-doped ZnO NPs. The result revealed that, as-prepared Cd-doped ZnO NPs found to have efficient degradation candidate materials.