bluuebunny/crossref_metadata_2025 huggingface dataset:
Rapid purification and multiparametric characterization of circulating small extracellular vesicles utilizing a label-free lab-on-a-chip device
Authors: Sharma Manju , Sheth Maulee , Poling Holly M. , Kuhnell Damaris , Langevin Scott M. , Esfandiari Leyla
Published: October 2023

Nano-scale extracellular vesicles are lipid-bilayer delimited particles that are naturally secreted by all cells and have emerged as valuable biomarkers for a wide range of diseases. Efficient isolation of small extracellular vesicles while maintaining yield and purity is crucial to harvest their potential in diagnostic, prognostic, and therapeutic applications. Most conventional methods of isolation suffer from significant shortcomings, including low purity or yield, long duration, need for large sample volumes, specialized equipment, trained personnel, and high costs. To address some of these challenges, our group has reported a novel insulator-based dielectrophoretic device for rapid isolation of small extracellular vesicles from biofluids and cell culture media based on their size and dielectric properties. In this study, we report a comprehensive characterization of small extracellular vesicles isolated from cancer-patients’ biofluids at a twofold enrichment using the device. The three-fold characterization that was performed using conventional flow cytometry, advanced imaging flow cytometry, and microRNA sequencing indicated high yield and purity of the isolated small extracellular vesicles. The device thus offers an efficient platform for rapid isolation while maintaining biomolecular integrity.
Divergent strategies in cranial biomechanics and feeding ecology of the ankylosaurian dinosaurs
Authors: Ballell Antonio , Mai Bohao , Benton Michael J.
Published: October 2023

Ankylosaurs were important megaherbivores of Jurassic and Cretaceous ecosystems. Their distinctive craniodental anatomy and mechanics differentiated them from coexisting hadrosaurs and ceratopsians, and morphological evidence suggests dietary niche partitioning between sympatric ankylosaurids and nodosaurids. Here, we investigate the skull biomechanics of ankylosaurs relative to feeding function. First, we compare feeding functional performance between nodosaurids and ankylosaurids applying finite element analysis and lever mechanics to the skulls of Panoplosaurus mirus (Nodosauridae) and Euoplocephalus tutus (Ankylosauridae). We also compare jaw performance across a wider sample of ankylosaurs through lever mechanics and phylogenetic comparative methods. Mandibular stress levels are higher in Euoplocephalus, supporting the view that Panoplosaurus consumed tougher foodstuffs. Bite force and mechanical advantage (MA) estimates indicate that Panoplosaurus had a relatively more forceful and efficient bite than Euoplocephalus. There is little support for a role of the secondary palate in resisting feeding loads in the two ankylosaur clades. Several ankylosaurs converged on similar jaw mechanics, while some nodosaurids specialised towards high MA and some ankylosaurids evolved low MA jaws. Our study supports the hypothesis that ankylosaurs partitioned dietary niches in Late Cretaceous ecosystems and reveals that the two main ankylosaur clades evolved divergent evolutionary pathways in skull biomechanics and feeding habits.
Integrated biophysical matching of bacterial nanocellulose coronary artery bypass grafts towards bioinspired artery typical functions
Authors: Hülsmann Jörn , Fraune Theresa , Dodawatta Baratha , Reuter Fabian , Beutner Martin , Beck Viktoria , Hackert-Oschätzchen Matthias , Ohl Claus Dieter , Bettenbrock Katja , Janiga Gabor , Wippermann Jens , Wacker Max
Published: October 2023

Revascularization via coronary artery bypass grafting (CABG) to treat cardiovascular disease is established as one of the most important lifesaving surgical techniques worldwide. But the shortage in functionally self-adaptive autologous arteries leads to circumstances where the clinical reality must deal with fighting pathologies coming from the mismatching biophysical functionality of more available venous grafts. Synthetic biomaterial-based CABG grafts did not make it to the market yet, what is mostly due to technical hurdles in matching biophysical properties to the complex demands of the CABG niche. But bacterial Nanocellulose (BNC) Hydrogels derived by growing biofilms hold a naturally integrative character in function-giving properties by its freedom in designing form and intrinsic fiber architecture. In this study we use this integral to combine impacts on the luminal fiber matrix, biomechanical properties and the reciprocal stimulation of microtopography and induced flow patterns, to investigate biomimetic and artificial designs on their bio-functional effects. Therefore, we produced tubular BNC-hydrogels at distinctive designs, characterized the structural and biomechanical properties and subjected them to in vitro endothelial colonization in bioreactor assisted perfusion cultivation. Results showed clearly improved functional properties and gave an indication of successfully realized stimulation by artery-typical helical flow patterns.
Automated maternal behavior during early life in rodents (AMBER) pipeline
Authors: Lapp Hannah E. , Salazar Melissa G. , Champagne Frances A.
Published: October 2023

Mother-infant interactions during the early postnatal period are critical for infant survival and the scaffolding of infant development. Rodent models are used extensively to understand how these early social experiences influence neurobiology across the lifespan. However, methods for measuring postnatal dam-pup interactions typically involve time-consuming manual scoring, vary widely between research groups, and produce low density data that limits downstream analytical applications. To address these methodological issues, we developed the Automated Maternal Behavior during Early life in Rodents (AMBER) pipeline for quantifying home-cage maternal and mother–pup interactions using open-source machine learning tools. DeepLabCut was used to track key points on rat dams (32 points) and individual pups (9 points per pup) in postnatal day 1–10 video recordings. Pose estimation models reached key point test errors of approximately 4.1–10 mm (14.39 pixels) and 3.44–7.87 mm (11.81 pixels) depending on depth of animal in the frame averaged across all key points for dam and pups respectively. Pose estimation data and human-annotated behavior labels from 38 videos were used with Simple Behavioral Analysis (SimBA) to generate behavior classifiers for dam active nursing, passive nursing, nest attendance, licking and grooming, self-directed grooming, eating, and drinking using random forest algorithms. All classifiers had excellent performance on test frames, with F1 scores above 0.886. Performance on hold-out videos remained high for nest attendance (F1 = 0.990), active nursing (F1 = 0.828), and licking and grooming (F1 = 0.766) but was lower for eating, drinking, and self-directed grooming (F1 = 0.534–0.554). A set of 242 videos was used with AMBER and produced behavior measures in the expected range from postnatal 1–10 home-cage videos. This pipeline is a major advancement in assessing home-cage dam-pup interactions in a way that reduces experimenter burden while increasing reproducibility, reliability, and detail of data for use in developmental studies without the need for special housing systems or proprietary software.
Effect of surface topography and wettability on shear bond strength of Y-TZP ceramic
Authors: Wongsue Suriyakul , Thanatvarakorn Ornnicha , Prasansuttiporn Taweesak , Nimmanpipug Piyarat , Sastraruji Thanapat , Hosaka Keiichi , Foxton Richard M. , Nakajima Masatoshi
Published: October 2023

Zirconia ceramics have been widely used as dental restorations due to their esthetic appearance and high flexural strength. The bonding of zirconia with resin cement should rely on both mechanical and chemical bonds. This study was performed to investigate the effect of zirconia surface topography and its wettability after surface pretreatments on the microshear bond strength (μSBS) of a resin cement. Zirconia slabs were prepared and randomly divided into 5 groups based on the surface treatment as follows: no treatment (control), air abrasion (AB), etching with hydrofluoric acid (F), the mixture of hydrofluoric acid and nitric acid (FN), or the mixture of hydrochloric acid and nitric acid (CN) for 10 min. The specimens were subjected to investigation of surface roughness characteristics [average roughness (Ra), peak-to-valley average distance (Rpv), skewness (Rsk), and kurtosis (Rku)] using atomic force microscopy (AFM) and measurements of surface contact angle (θc) and μSBS of a resin cement. In addition, the area % of the nanoscale surface irregularity (nSI%) was calculated from the AFM images. The effects of nSI%, Ra and θc on the μSBS were analyzed by multiple linear regression analysis (p < 0.05). Multiple regression analysis revealed that the nSI% was the most predominant factor for the μSBS (p < 0.001). A surface with larger nSI%, higher Ra and relatively lower θc was essential for establishing a reliable resin-zirconia bond.
Corrosion-driven droplet wetting on iron nanolayers
Authors: Ricard Aurelien , Restagno Frederic , Jang Yun Hee , Lansac Yves , Raspaud Eric
Published: October 2023

The classical Evans’ drop describes a drop of aqueous salt solution, placed on a bulk metal surface where it displays a corrosion pit that grows over time producing further oxide deposits from the metal dissolution. We focus here on the corrosion-induced droplet spreading using iron nanolayers whose semi-transparency allowed us to monitor both iron corrosion propagation and electrolyte droplet behavior by simple optical means. We thus observed that pits grow under the droplet and merge into a corrosion front. This front reached the triple contact line and drove a non radial spreading, until it propagated outside the immobile droplet. Such chemically-active wetting is only observed in the presence of a conductive substrate that provides strong adhesion of the iron nanofilm to the substrate. By revisiting the classic Evan’s drop experiment on thick iron film, a weaker corrosion-driven droplet spreading is also identified. These results require further investigations, but they clearly open up new perspectives on substrate wetting by corrosion-like electrochemical reactions at the nanometer scale.
Study on pore structure and the mechanical properties of sandstone-concrete binary under freeze–thaw environment
Authors: Hu Anlong , Xue Guobin , Shang Zhipeng , Cao Zhe , Wang Xiaoping , Fu Yintao , Huang Xiaoqing
Published: October 2023

In China's cold region water conservancy and hydropower projects, the contact interface between the dam and the reservoir bank rock is prone to cracking under external loading and freeze–thaw action, which may lead to dam-bank failure and damage and cause engineering disasters. The NMR (Nuclear Magnetic Resonance) tests and uniaxial compression tests of concrete, sandstone, and sandstone-concrete composite after different numbers of freeze–thaw cycles were carried out to analyze the pore structure development and uniaxial compression mechanical properties of the three types of specimens under different numbers of freeze–thaw cycles. The results show that freeze–thaw cycling promotes the development of pores in sandstone and concrete, and sandstone is more sensitive to low-temperature freeze–thaw than concrete. The UCS (uniaxial compressive strength) of the sandstone-concrete binary changed in a V-shaped with the increase of the dip angle of the cemented interface, and the angle had no obvious effect on the microscopic pores. The freeze–thaw effect on the deterioration of the microscopic pore structure and mechanical properties of the sandstone-concrete binary has a similar effect pattern, in which the deterioration rate of porosity and compressive strength is faster in the early freeze–thaw period, slower in the middle period, and increases in the later period compared with the middle period, but the increase is smaller than that in the early period of freeze–thaw. In addition, the relationship between the porosity and UCS of the sandstone-concrete binary under the freeze–thaw cycle environment is a quadratic parabola.
Association between iron status markers and kidney outcome in patients with chronic kidney disease
Authors: Fujisawa Hironobu , Nakayama Masaru , Haruyama Naoki , Fukui Akiko , Yoshitomi Ryota , Tsuruya Kazuhiko , Nakano Toshiaki , Kitazono Takanari
Published: October 2023

Several studies conducted in patients with various stages of chronic kidney disease (CKD) have investigated the association of iron status markers, such as transferrin saturation (TSAT) and serum ferritin, with kidney outcomes. However, the associations were inconsistent and remain strongly debated. Therefore, we aimed to investigate whether TSAT and serum ferritin levels were associated with kidney outcome in such a population. In this study, 890 patients who were admitted for the evaluation of and education for CKD were prospectively followed. Primary kidney outcome was a composite of doubling of serum creatinine, end-stage kidney disease, or death due to kidney failure. Participants were divided into quartiles (Q1–Q4) according to TSAT or serum ferritin levels. During a median follow-up period of 2.8 years, kidney events occurred in 358 patients. In the multivariable Cox analyses, compared with Q3 of TSAT, the hazard ratios (95% confidence intervals) for Q1, Q2, and Q4 were 1.20 (0.87, 1.66), 1.38 (1.01, 1.87), and 1.14 (0.82, 1.59), respectively. Compared with Q2 of serum ferritin, lower and higher quartiles had a significantly increased risk for kidney outcome; hazard ratios (95% confidence intervals) for Q1, Q3, and Q4 were 1.64 (1.18, 2.27), 1.71 (1.24, 2.37), and 1.52 (1.10, 2.10), respectively. A Fine-Gray model with death before kidney events as a competing risk showed results similar to the above. In CKD, lower and higher ferritin levels were independent risk factors for kidney disease progression.
Clinical outcomes and prognostic factors in the surgical treatment of spinal dural arteriovenous fistulas: a retrospective study of 118 patients
Authors: Peng Youheng , Ren Yanming , Hou Jiguang , Zhang Changwei , He Min , Huang Bowen , Chen Tengyun , Li Jin
Published: October 2023

Spinal dural arteriovenous fistulas (SDAVFs) are the most common type of spinal vascular malformations (AVMs), constituting approximately 70% of all spinal AVMs. The impact of various clinical and radiologic features on the outcomes in patients with SDAVFs is still controversial. The purpose of the study is to investigate the clinical outcomes and prognostic factors in patients with surgically treated SDAVFs in a single center. A retrospective review was performed for all patients with SDAVFs from January 2013 to September 2021 who underwent surgery at our institution. Medical records and pre- and postoperative imaging data were analyzed. Neurological function status was evaluated by modified Aminoff-Logue Scale (mALS). Student’s t-test, Wilcoxon rank sum test, χ2 test and logistic regression were used to find significant prognostic factors. P values < 0.05 were considered significant. One hundred and eighteen patients were ultimately included in the study. By comparing preoperative and postoperative mALS, 69 (58.5%) patients experienced improvement, and 49 (41.5%) patients showed no improvement (worse or unchanged). Wilcoxon rank sum test showed that there was a difference between the improvement group and the no improvement group in preoperative mALS Micturition score and preoperative mALS Defecation score. The logistic regression revealed that preoperative mALS Gait score was associated with clinical improvement after surgery in patients with SDAVFs. Surgical treatment of SDAVFs is a safe and effective procedure and can lead to symptom improvement or stabilization in most patients. Preoperative neurological function status was the only factor associated with clinical prognosis.
Exploring the determinants influencing suicidal ideation and depression in gastrointestinal cancer patients
Authors: Choudhury Avishek , Shahsavar Yeganeh
Published: October 2023

Studies have shown a heightened prevalence of depression and suicidal ideation among patients with Gastrointestinal Cancer (GIC). GIC patients are at a 1.5- to threefold increased risk of suicide and depression compared to other cancer patients. This study investigates the interplay of internet use, family burden, and emotional support on mental health (depression) and suicidal ideation among patients with GIC. The study involves 202 respondents of which 78 were undergoing GIC treatment during this study. Using structural equation modeling, our findings indicate a substantial negative correlation between mental health and suicidal ideation. Overall, suicidal ideation (median score) was noticeably lower in patient who completed their treatment with noticeable individuals with exceptionally high SI even after completing the treatment. Notably, participants who had completed their treatment demonstrated a significantly stronger correlation between emotional support and mental health compared to those who were still undergoing treatment. Age was found to moderate the mental health-suicidal ideation link significantly. Internet usage for health-related information was also inversely correlated with mental health (directly) and suicidal ideation (indirectly). We noted that the influence of emotional support on mental health was significantly higher among individuals who completed their treatment compared to those who were undergoing their GIC treatment. Family burden emerged as significant negative influences on mental health, while emotional support positively impacted mental health. The findings of this study contribute towards a deeper understanding of suicide risk factors in GIC patients, potentially shaping more effective preventive strategies.
FGFR blockade inhibits targeted therapy-tolerant persister in basal FGFR1- and FGF2-high cancers with driver oncogenes
Authors: Furugaki Koh , Fujimura Takaaki , Mizuta Hayato , Yoshimoto Takuya , Asakawa Takashi , Yoshimura Yasushi , Yoshiura Shigeki
Published: October 2023

Cancer cell resistance arises when tyrosine kinase inhibitor (TKI)-targeted therapies induce a drug-tolerant persister (DTP) state with growth via genetic aberrations, making DTP cells potential therapeutic targets. We screened an anti-cancer compound library and identified fibroblast growth factor receptor 1 (FGFR1) promoting alectinib-induced anaplastic lymphoma kinase (ALK) fusion-positive DTP cell’s survival. FGFR1 signaling promoted DTP cell survival generated from basal FGFR1- and fibroblast growth factor 2 (FGF2)-high protein expressing cells, following alectinib treatment, which is blocked by FGFR inhibition. The hazard ratio for progression-free survival of ALK-TKIs increased in patients with ALK fusion-positive non-small cell lung cancer with FGFR1- and FGF2-high mRNA expression at baseline. The combination of FGFR and targeted TKIs enhanced cell growth inhibition and apoptosis induction in basal FGFR1- and FGF2-high protein expressing cells with ALK-rearranged and epidermal growth factor receptor (EGFR)-mutated NSCLC, human epidermal growth factor receptor 2 (HER2)-amplified breast cancer, or v-raf murine sarcoma viral oncogene homolog B1 (BRAF)-mutated melanoma by preventing compensatory extracellular signal-regulated kinase (ERK) reactivation. These results suggest that a targeted TKI-induced DTP state results from an oncogenic switch from activated oncogenic driver signaling to the FGFR1 pathway in basal FGFR1- and FGF2-high expressing cancers and initial dual blockade of FGFR and driver oncogenes based on FGFR1 and FGF2 expression levels at baseline is a potent treatment strategy to prevent acquired drug resistance to targeted TKIs through DTP cells regardless of types of driver oncogenes.
New insights in the targets of action of dimethyl fumarate in endothelial cells: effects on energetic metabolism and serine synthesis in vitro and in vivo
Authors: Ocaña Mª Carmen , Bernal Manuel , Yang Chendong , Caro Carlos , Domínguez Alejandro , Vu Hieu S. , Cárdenas Casimiro , García-Martín María Luisa , DeBerardinis Ralph J. , Quesada Ana R. , Martínez-Poveda Beatriz , Medina Miguel Ángel
Published: October 2023

Dimethyl fumarate is an ester from the Krebs cycle intermediate fumarate. This drug is approved and currently used for the treatment of psoriasis and multiple sclerosis, and its anti-angiogenic activity was reported some years ago. Due to the current clinical relevance of this compound and the recently manifested importance of endothelial cell metabolism on the angiogenic switch, we wanted to elucidate whether dimethyl fumarate has an effect on energetic metabolism of endothelial cells. Different experimental approximations were performed in endothelial cells, including proteomics, isotope tracing and metabolomics experimental approaches, in this work we studied the possible role of dimethyl fumarate in endothelial cell energetic metabolism. We demonstrate for the first time that dimethyl fumarate promotes glycolysis and diminishes cell respiration in endothelial cells, which could be a consequence of a down-regulation of serine and glycine synthesis through inhibition of PHGDH activity in these cells. Dimethyl fumarate alters the energetic metabolism of endothelial cells in vitro and in vivo through an unknown mechanism, which could be the cause or the consequence of its pharmacological activity. This new discovery on the targets of this compound could open a new field of study regarding the mechanism of action of dimethyl fumarate.
Protected areas reduce deforestation and degradation and enhance woody growth across African woodlands
Authors: McNicol Iain M. , Keane Aidan , Burgess Neil D. , Bowers Samuel J. , Mitchard Edward T. A. , Ryan Casey M.
Published: October 2023

Protected areas are increasingly promoted for their capacity to sequester carbon, alongside biodiversity benefits. However, we have limited understanding of whether they are effective at reducing deforestation and degradation, or promoting vegetation growth, and the impact that this has on changes to aboveground woody carbon stocks. Here we present a new satellite radar-based map of vegetation carbon change across southern Africa’s woodlands and combine this with a matching approach to assess the effect of protected areas on carbon dynamics. We show that protection has a positive effect on aboveground carbon, with stocks increasing faster in protected areas (+0.53% per year) compared to comparable lands not under protection (+0.08% per year). The positive effect of protection reflects lower rates of deforestation (−39%) and degradation (−25%), as well as a greater prevalence of vegetation growth (+12%) inside protected lands. Areas under strict protection had similar outcomes to other types of protection after controlling for differences in location, with effect scores instead varying more by country, and the level of threat. These results highlight the potential for protected areas to sequester aboveground carbon, although we caution that in some areas this may have negative impacts on biodiversity, and human wellbeing.
Selective MCL-1 inhibitor ABBV-467 is efficacious in tumor models but is associated with cardiac troponin increases in patients
Authors: Yuda Junichiro , Will Christine , Phillips Darren C. , Abraham Linu , Alvey Cory , Avigdor Abraham , Buck Wayne , Besenhofer Lauren , Boghaert Erwin , Cheng Dong , Cojocari Dan , Doyle Kelly , Hansen T. Matthew , Huang Kevin , Johnson Eric F. , Judd Andrew S. , Judge Russell A. , Kalvass John C. , Kunzer Aaron , Lam Lloyd T. , Li Rachel , Martin Ruth L. , Mastracchio Anthony , Mitten Mike , Petrich Adam , Wang Jin , Ward James E. , Zhang Haichao , Wang Xilu , Wolff Johannes E. , Bell-McGuinn Katherine M. , Souers Andrew J.
Published: October 2023

Background

MCL-1 is a prosurvival B-cell lymphoma 2 family protein that plays a critical role in tumor maintenance and survival and can act as a resistance factor to multiple anticancer therapies. Herein, we describe the generation and characterization of the highly potent and selective MCL-1 inhibitor ABBV-467 and present findings from a first-in-human trial that included patients with relapsed/refractory multiple myeloma (NCT04178902).

Methods

Binding of ABBV-467 to human MCL-1 was assessed in multiple cell lines. The ability of ABBV-467 to induce tumor growth inhibition was investigated in xenograft models of human multiple myeloma and acute myelogenous leukemia. The first-in-human study was a multicenter, open-label, dose-escalation study assessing safety, pharmacokinetics, and efficacy of ABBV-467 monotherapy.

Results

Here we show that administration of ABBV-467 to MCL-1-dependent tumor cell lines triggers rapid and mechanism-based apoptosis. In vivo, intermittent dosing of ABBV-467 as monotherapy or in combination with venetoclax inhibits the growth of xenografts from human hematologic cancers. Results from a clinical trial evaluating ABBV-467 in patients with multiple myeloma based on these preclinical data indicate that treatment with ABBV-467 can result in disease control (seen in 1 patient), but may also cause increases in cardiac troponin levels in the plasma in some patients (seen in 4 of 8 patients), without other corresponding cardiac findings.

Conclusions

The selectivity of ABBV-467 suggests that treatment-induced troponin release is a consequence of MCL-1 inhibition and therefore may represent a class effect of MCL-1 inhibitors in human patients.
Photocatalysis with atomically thin sheets
Authors: Yang Ruijie , Fan Yingying , Hu Jinguang , Chen Zhangxin , Shin Hyeon Suk , Voiry Damien , Wang Qian , Lu Qingye , Yu Jimmy C. , Zeng Zhiyuan
Published: October 2023

Atomically thin sheets are ideal platforms for atomic-level deciphering and mastery of electronic band structures and charge separation and transfer. In this review, we analyze the atomic-level photocatalysis occurring on atomically thin sheets.
Reticular framework materials for photocatalytic organic reactions
Authors: Huang Ning-Yu , Zheng Yu-Tao , Chen Di , Chen Zhen-Yu , Huang Chao-Zhu , Xu Qiang
Published: October 2023

Photocatalytic organic reactions, harvesting solar energy to produce high value-added organic chemicals, have attracted increasing attention as a sustainable approach to address the global energy crisis and environmental issues.
A dual-mode “signal-on” split-type aptasensor for bisphenol A via target-induced hybridization chain reaction amplification
Authors: Wu You , Wang Zheng , Li Jing , Yang Jingjing , Shen Yinzhuo , Li Hongbo , Hu Xiao-Ya , Xu Qin
Published: October 2023

A sensitive split-type aptasensor was constructed for detection of bisphenol A via target-induced HCR amplification with electrochemical and photoelectrochemical dual-signals.
Detecting emerald green in 19thC book bindings using vis-NIR spectroscopy
Authors: Gil M. Pilar , Henderson Elizabeth , Burdge Jessica , Kotze Erica , McCarthy William
Published: October 2023

Emerald green containing bookbindings have a distinctive spectral reflectance signature in the visible region of the spectrum.
Reshaping carbon-coated Mn2Mo3O8 nanotubes and enhanced sodium storage performance
Authors: Zhang Lifeng , Xue Liyue , Bai Jiaxi , He Kexin , Lu Bangmei
Published: October 2023

Mn2Mo3O8/C nanotubes reshaped from micron-sized MnMoO4 blocks using a simple method exhibited enhanced sodium storage performance.
Design of internally integrated in-plane electrodes for superior flexible hybrid zinc-ion capacitor devices
Authors: Zhao Simiao , Li Haojie , Bai Jiaxuan , Ma Hui , Dong Yifan , Tian Xiaocong
Published: October 2023

A unique device configuration based on internally integrated electrodes is proposed for flexible hybrid zinc-ion capacitor devices, which exhibit outstanding electrochemical behaviors.
A cavitand-based supramolecular artificial light-harvesting system with sequential energy transfer for photocatalysis
Authors: Liu Qian , Zuo Minzan , Wang Kaiya , Hu Xiao-Yu
Published: October 2023

A supramolecular artificial light-harvesting system with two-step sequential energy transfer processes was fabricated for the photocatalysis of a cross-dehydrogenative coupling reaction.
Multicolor circularly polarized luminescence inversion of metal–organic supramolecular polymers
Authors: Fu Kuo , Liu Guofeng
Published: October 2023

Metal–organic supramolecular polymers with multicolor CPL and handedness inversion were constructed from the co-assembly of pyridine-cyanostilbene-cholesterol (PCSPCC) and metal salts by modulating the treatment modes, solvents, and metal ions.
Liquid metal–hydrogel composites for flexible electronics
Authors: Chen Jianhui , Tian Gongwei , Liang Cuiyuan , Yang Dan , Zhao Qinyi , Liu Yan , Qi Dianpeng
Published: October 2023

As an emerging functional material, liquid metal–hydrogel composites exhibit excellent biosafety, high electrical conductivity, tunable mechanical properties etc., providing a unique platform for a wide range of flexible electronics applications.
Transition metal-free and temperature dependent one-pot access to phenanthrene-fused heterocycles via a 1,3-dipolar cycloaddition pathway
Authors: Reddy Mokilla Ramachandra , Rajakumara Eerappa , Satyanarayana Gedu
Published: October 2023

A versatile, operationally simple, temperature-dependent, and transition metal-free one-pot protocol has been devised to prepare novel phenanthrene-fused pyrazoles/isoxazoles. This protocol effectively constructed two C–N bonds and one C–C bond.
Recent applications of organic cages in sensing and separation processes in solution
Authors: La Cognata Sonia , Amendola Valeria
Published: October 2023

Cages at work: structural tunability results in tailored properties, which makes these systems suitable for countless applications in sensing and separation processes, both in solution and the solid state.
Transient absorption spectroscopy reveals that slow bimolecular recombination in SrTiO3 underpins its efficient photocatalytic performance
Authors: Wilson Anna A. , Hart Lucy , Shalvey Thomas , Sachs Michael , Xu Weidong , Moss Benjamin , Mazzolini Eva , Mumtaz Asim , Durrant James R.
Published: October 2023

The charge carrier dynamics of SrTiO3 are measured on fast (ps–ns) timescales, to reveal remarkably slow bimolecular recombination compared to alternative metal oxides commonly employed in photocatalytic applications.
Na2Fe2Se2O: a double anti-perovskite with prevalence of anionic redox activity in Na-ion batteries
Authors: Gorbunov Mikhail V. , Doert Thomas , Mikhailova Daria
Published: October 2023

Na2Fe2Se2O with the I4/mmm space group was studied in sodium-ion batteries, delivering a reversible specific capacity of more than 140 mA h g−1. Operando XRD and XAS confirm its redox bifunctionality and partial decomposition, not influencing the overall performance.
Iron-based fluorophosphate Na2FePO4F as a cathode for aqueous zinc-ion batteries
Authors: Singh Deepa , Hu Yang , Meena Sher Singh , Vengarathody Rishikesh , Fichtner Maximilian , Barpanda Prabeer
Published: October 2023

Aqueous zinc-ion batteries form a key post-Li-ion batteries to cater the rising demand for grid storage.
Record size crystal growth and laser performance of Yb-doped lutetium oxide (Yb:Lu2O3) single crystal
Authors: Wang Guiji , Yin Yanru , Zhang Baitao , Jia Zhitai , Tao Xutang
Published: October 2023

An Yb:Lu2O3 crystal with dimensions of Φ50.7 × 43.0 mm3 was grown and its laser performance was determined.
Controllable sulfidation of polymetallic nickel cobalt molybdenum layered double hydroxides on Ni foam for high-performance hybrid supercapacitors
Authors: Luo Dapeng , Zou Jinping , Wei Zhaohui , Ye Xiaoyun , Wang Qianting , Ma Li-An
Published: October 2023

The effect of sulfidation time on the morphology, structure and electrochemical properties of the NCMS was investigated. The NCMS-2@AC hybrid supercapacitors provide a high energy density and excellent excellent cycle stability.
Intermolecular interactions in clusters of ethylammonium nitrate and 1-amino-1,2,3-triazole
Authors: Kim Shinae , Conrad Justin A. , Tow Garrett M. , Maginn Edward J. , Boatz Jerry A. , Gordon Mark S.
Published: October 2023

The intermolecular interaction energies, including hydrogen bonds (H-bonds), of clusters of the ionic liquid ethylammonium nitrate (EAN) and 1-amino-1,2,3-triazole (1-AT) based deep eutectic propellants (DeEP) are examined.
MatAR: dynamic augmented reality platform for accessible molecular visualization
Authors: Mohammadi Khatereh , Bentria El Tayeb , Bonakala Satayanaraya , Medina Johanne , Ayeche Lamis , Fadlallah Joelle , El Mellouhi Fedwa
Published: October 2023

MatAR is an educational AR app designed to enhance accessibility for colorblind learners and support sustainable and inclusive materials science and STEM education.
Surface/interfacial transport through pores control desalination mechanisms in 2D carbon-based membranes
Authors: Zhao Xiaoyang , Meng Kun , Niu Yutao , Ming Sen , Rong Ju , Yu Xiaohua , Zhang Yannan
Published: October 2023

Inspired by the multi-porous zeolite structure and carbon materials with promising adsorption properties, a novel two-dimensional metallic carbon-based seawater desalination membrane has been shown to possess great desalination application potential.
Photogating induced high sensitivity and speed from heterostructure of few-layer MoS2 and reduced graphene oxide-based photodetector
Authors: Das Chayan , Kumar Ashok , Kumar Suresh , Dambhare Neha V. , Kumar Mahesh , Rath Arup K. , Sahu Satyajit
Published: October 2023

We synthesized 2D MoS2, decorated it with rGO, and created rGO/MoS2 heterojunction-based device, which showed an excellent responsivity of 3.36 A W−1 along with good stability.
Dissociation cross sections and rates in O2 + N collisions: molecular dynamics simulations combined with machine learning
Authors: Huang Xia , Gu Kun-Ming , Guo Chang-Min , Cheng Xin-Lu
Published: October 2023

The state-selected dissociation rates of O2 + N on 2A′, 4A′ and especially 6A′ PESs were computed. A complete database of rovibrationally detailed cross sections and rates has been constructed by combining the QCT simulation with machine learning.
Two-dimensional AlN/TMO van der Waals heterojunction as a promising photocatalyst for water splitting driven by visible light
Authors: Tao Ji , Xu Liang , Li Can , Xiong Shixian , Xu Zhiqiang , Shao Jingyao , Cao Lei , Zhang Ying , Dong Kejun , Wang Ling-Ling
Published: October 2023

The AlN/WO2 heterojunction photocatalyst for water splitting.
Emerging transition metal nitrides in solar energy conversion: design strategies and future perspectives for efficient photocatalysis
Authors: Qi Weiliang , Cheng Zhixing , Liu Siqi , Yang Minghui
Published: October 2023

This perspective provides a range of design strategies aimed at enhancing the efficiency and stability of transition metal nitride-based catalytic materials.
Bicyclic (alkyl)(amino)carbene (BICAAC)-supported phosphinidenes
Authors: Yadav Ritu , Das Bindusagar , Singh Ashi , Anmol  , Sharma Ankita , Majumder Chinmoy , Kundu Subrata
Published: October 2023

This paper provides the synthesis, structure, and bonding analysis of three halo-phosphinidenes and a bis-phosphinidene stabilized by a bicyclic (alkyl)(amino)carbene (BICAAC).
Moisturized 2-dimensional halide perovskite generates a power density of 30 mW cm−3
Authors: Ma Chunqing , Choi Yeon-Woo , Kang Donghyeon , Kim Bosung , Choi Seung-Gu , Lee Jin-Wook , Kim Sang-Woo , Park Nam-Gyu
Published: October 2023

We report here for the first time on the ionovoltaic effect of 2-dimensional (2D) halide perovskite, which can generate electricity by absorbing moisture.
Operando insights into correlating CO coverage and Cu–Au alloying with the selectivity of Au NP-decorated Cu2O nanocubes during the electrocatalytic CO2 reduction
Authors: Rettenmaier Clara , Herzog Antonia , Casari Daniele , Rüscher Martina , Jeon Hyo Sang , Kordus David , Luna Mauricio Lopez , Kühl Stefanie , Hejral Uta , Davis Earl M. , Chee See Wee , Timoshenko Janis , Alexander Duncan T.L. , Bergmann Arno , Cuenya Beatriz Roldan
Published: October 2023

Adding small amounts of Au Nanoparticles on Cu2O Nanocubes boost the selectivity of C2+ products during electrocatalytic CO2 reduction reaction.
Selective demethylation reactions of biomass-derived aromatic ether polymers for bio-based lignin chemicals
Authors: Harth Florian M. , Hočevar Brigita , Kozmelj Tina Ročnik , Jasiukaitytė-Grojzdek Edita , Blüm Jana , Fiedel Michael , Likozar Blaž , Grilc Miha
Published: October 2023

Unlocking lignin potential by selective demethylation of its monomers and oligomers.
Metal-free, tert-butyl nitrite promoted C(sp2)–S coupling reaction: the synthesis of aryl dithiocarbamates and analysis of antimicrobial activity by ‘in silico’ and ‘in vitro’ methods for drug modification
Authors: Pal Satyajit , Sarkar Subhankar , Mukherjee Anindita , Kundu Anupam , Sen Animesh , Rath Jnanendra , Santra Sougata , Zyryanov Grigory V. , Majee Adinath
Published: October 2023

An environmentally friendly, metal-free, and efficient C(sp2)–S coupling reaction protocol between aniline and low-cost tetraalkylthiuram disulfides was developed to synthesize aryl dithiocarbamates.
High-precision rapid testing of omicron SARS-CoV-2 variants in clinical samples using AI-nanopore
Authors: Murakami Kaoru , Kubota Shimpei I. , Tanaka Kumiko , Tanaka Hiroki , Akabane Keiichiroh , Suzuki Rigel , Shinohara Yuta , Takei Hiroyasu , Hashimoto Shigeru , Tanaka Yuki , Hojyo Shintaro , Sakamoto Osamu , Naono Norihiko , Takaai Takayui , Sato Kazuki , Kojima Yuichi , Harada Toshiyuki , Hattori Takeshi , Fuke Satoshi , Yokota Isao , Konno Satoshi , Washio Takashi , Fukuhara Takasuke , Teshima Takanori , Taniguchi Masateru , Murakami Masaaki
Published: October 2023

Our results demonstrate the AI-nanopore platform is an effective diagnostic tool for SARS-CoV-2 variants including the next pandemic.
Liquid Cu–Zn catalyzed growth of graphene single-crystals
Authors: Li Lin , Li Minghui , Zhang Ruijie , Zhang Qing , Li Hang , Geng Dechao
Published: October 2023

The controllable synthesis of millimeter-sized single-crystal monolayer graphene on a liquid Cu–Zn alloy by suppressing nucleation is reported.
Structures and magnetic studies of four new Ni(ii) coordination polymers built using symmetrical tetracarboxylate and N-donor linkers
Authors: Zhang Xiaoyu , Qin Tianrui , Liu Yichen , An Ning , Afzal Mohd , Alarifi Abdullah , Muddassir Mohd. , Sakiyama Hiroshi , Mohanty Aurobinda , Dong Xiuyan
Published: October 2023

Four new Ni(ii) coordination polymers (1–4) have been successfully synthesized using 5,5′-(ethene-1,2-diyl)diisophthalic acid (H4L) and different N-donor ancillary ligands. Furthermore, the magnetic properties of 1–4 were investigated in detail.
The synthesis of Cu-TCPP MOF/g-C3N4 heterojunctions as efficient photocatalysts for hydrogen generation
Authors: Lu Meihui , Dong Aichen , Li Xinyang , Liu Xuanqi , Zhang Ziqing , Tian Tao , Jing Liqiang
Published: October 2023

Semiconductor photocatalysis is a potential solution to meet energy needs with green and inexhaustible solar energy.
One-pot and sustainable liquid-phase peptide extension for synthesis of C-terminal amidation peptides aided by small molecular tags
Authors: Li Haidi , Jin Yuankui , Wang Lianjun , Zhang Linyan , Liu Tianyu , Liu Yu , Liang Taigang
Published: October 2023

A series of phosphonate or aliphatic-based tags were developed to achieve sustainable peptide synthesis, resulting in over a 10-fold reduction in solvent usage compared to SPPS.
Synthesis of cyclic silyl enol ethers from α-Aryl-α-diazoketones: new building blocks for preparation of indanones and α,β-unsaturated ketones
Authors: Liu Yueqiang , Zhang Sheng , Li Yang , Yu Xiaoqiang , Feng Xiujuan , Yamamoto Yoshinori , Bao Ming
Published: October 2023

A new strategy for in situ generation of vinyl cation intermediates from α-diazocarbonyl compounds is described in this paper.
First-principles study of mercaptoundecanoic acid molecule adsorption and gas molecule penetration onto silver surface: an insight for corrosion protection
Authors: Kim Chung-Hyok , Ryu Chol , Ro Yong-Hak , O Song-Il , Yu Chol-Jun
Published: October 2023

First-principles simulations of adsorption of MUA molecule on Ag(1 0 0) and Ag(1 1 1) surfaces, adsorption of H2O, H2S and O2 molecules and their penetrations onto the Ag surface were performed to elaborate the mechanism of corrosion protection.
Two-dimensional mesoporous metals: a new era for designing functional electrocatalysts
Authors: Lv Hao , Liu Ben
Published: October 2023

This Perspective summarizes recent progress in the synthesis and electrocatalytic applications of two-dimensional mesoporous metals and thus ensures a new era for designing high-performance functional electrocatalysts.
Implications of Ga promotion and metal–oxide interface from tailored PtGa propane dehydrogenation catalysts supported on carbon
Authors: Brack Enzo , Plodinec Milivoj , Willinger Marc-Georg , Copéret Christophe
Published: October 2023

Comparison of carbon-supported Pt and PtGa propane dehydrogenation catalysts via electron microscopy elucidates the role of Ga promotion in amorphous PtGa nanoparticles via Pt-site isolation, driving catalytic stability and selectivity.
Glass formation and dynamics of model polymer films with one versus two active interfaces
Authors: Ghanekarade Asieh , Simmons David S.
Published: October 2023

Simulations predict that dynamical gradients in asymmetric finite films obey a gradient additivity model, leading to a nonmonotonicity of the relaxation spectrum breadth with film thickness and providing a target for measurement of gradient range.
Using a molecular additive to control chiral supramolecular assembly and the subsequent chirality transfer process
Authors: Yao Qingyuan , Liu Rongjuan , Yang Zhijie , Wei Jingjing
Published: October 2023

Introduction of molecular additives can nontrivially not only control the supramolecular chirality, but also control the chirality transfer from one entity to another.
Rashba effect and point-defect engineering synergistically improve the thermoelectric performance of the entropy-stabilized Sn0.8Ge0.2Te0.8Se0.2alloy
Authors: Fu Liangwei , Jin Kangpeng , Zhang Dan , Zhang Chenghao , Nie Haonan , Zhen Zixiong , Xiong Pan , Huang Ming , He Jiaqing , Xu Biao
Published: October 2023

The Rashba effect and point defect scattering significantly enhancezTof entropy-stabilized Sn0.8Ge0.2Te0.8Se0.2with disorder on cationic and anionic sites.
Ultra-high dispersion of Ni-based OER catalysts on graphene 3D networks enhances the in situ Fe3+ catalytic activation
Authors: González-Ingelmo María , García Miriam López , Oropeza Freddy E. , Álvarez Patricia , Blanco Clara , Santamaría Ricardo , Rocha Victoria G.
Published: October 2023

Ultradispersed and nanosized Ni-based particles supported on 3D graphene networks by a freeze-casting method exhibit good catalytic properties towards the OER and outstanding Fe-ion activation from the impurities present in the alkaline electrolyte.
2D-Ti3C2Tx MXene-supported Cu2S nanoflakes for supercapacitors and electrocatalytic oxygen evolution reaction
Authors: Gogoi Debika , Karmur Rajeshvari Samatbhai , Das Manash R. , Ghosh Narendra Nath
Published: October 2023

Recently, the design of efficient multifunctional materials for supercapacitors and oxygen evolution reaction (OER) has become imperative in the field of energy storage and conversion.
Interfacial microenvironment regulation of FeOOH/S-Co heterostructure catalysts via S atoms for overall water splitting
Authors: Zang Zehao , Ren Yangyang , Li Xiang , Cheng Yahui , Li Lanlan , Yu Xiaofei , Yang Xiaojing , Lu Zunming , Zhang Xinghua , Liu Hui
Published: October 2023

Interface microenvironment regulation provides a new direction for designing efficient heterostructure electrocatalysts to produce sustainable green hydrogen through water splitting.
Core–shell structures of Cu2O constructed by carbon quantum dots as high-performance zinc-ion battery cathodes
Authors: Zhang Qu , Liu Penggao , Wang Tao , Liu Qian , Wu Dongling
Published: October 2023

Core–shell structure of Cu2O constructed by carbon quantum dots exhibited high discharge specific capacity and excellent rate performance. And the conversion-type zinc storage mechanism was confirmed by in situ XRD and in situ Raman technology.
Gelation of a metal oxide cluster for a proton exchange membrane operated under low humidity
Authors: Li Xinpei , Yu Qiang , Chen Kun , Cai Linkun , Liu Lu , Zhang Mingxin , Liu Yuan , Gu Yijie , Yin Jia-Fu , Yin Panchao
Published: October 2023

Metal oxide clusters are complexed with polyvinyl alcohol and glycerol into gel electrolytes, which serve as proton exchange membrane in fuel cell with maximum power density of 141 mW cm−2 under dry gas condition.
Applications of hot-exciton anthracene and imidazole derivatives in integrated organic blue-emitting diodes and ultraviolet photodetectors
Authors: Luo Qiao , Gao Yannan , Xu Huixia , Zhao Song , Dong Wenjian , Miao Yanqin , Wang Yating , Wang Hua , Yu Junsheng
Published: October 2023

Four hot-exciton blue emitters with different peripheral units were designed and applied in integrated organic light-emitting and ultraviolet photodetector devices. A detection rate of 2.53 × 1012 Jones and EQE of 7.3% were achieved.
The vascular Na,K-ATPase: clinical implications in stroke, migraine, and hypertension
Authors: Staehr Christian , Aalkjaer Christian , Matchkov Vladimir V.
Published: October 2023

In the vascular wall, the Na,K-ATPase plays an important role in the control of arterial tone. Through cSrc signaling, it contributes to the modulation of Ca2+ sensitivity in vascular smooth muscle cells. This review focuses on the potential implication of Na,K-ATPase-dependent intracellular signaling pathways in severe vascular disorders; ischemic stroke, familial migraine, and arterial hypertension. We propose similarity in the detrimental Na,K-ATPase-dependent signaling seen in these pathological conditions. The review includes a retrospective proteomics analysis investigating temporal changes after ischemic stroke. The analysis revealed that the expression of Na,K-ATPase α isoforms is down-regulated in the days and weeks following reperfusion, while downstream Na,K-ATPase-dependent cSrc kinase is up-regulated. These results are important since previous studies have linked the Na,K-ATPase-dependent cSrc signaling to futile recanalization and vasospasm after stroke. The review also explores a link between the Na,K-ATPase and migraine with aura, as reduced expression or pharmacological inhibition of the Na,K-ATPase leads to cSrc kinase signaling up-regulation and cerebral hypoperfusion. The review discusses the role of an endogenous cardiotonic steroid-like compound, ouabain, which binds to the Na,K-ATPase and initiates the intracellular cSrc signaling, in the pathophysiology of arterial hypertension. Currently, our understanding of the precise control mechanisms governing the Na,K-ATPase/cSrc kinase regulation in the vascular wall is limited. Understanding the role of vascular Na,K-ATPase signaling is essential for developing targeted treatments for cerebrovascular disorders and hypertension, as the Na,K-ATPase is implicated in the pathogenesis of these conditions and may contribute to their comorbidity.