bluuebunny/crossref_metadata_2025 huggingface dataset:
Implications of COVID-19 pandemic on laparoscopic and abdominal surgery for benign adnexal conditions: Single center experience
Authors: Dokić Milan , Milošević Branislav , Dotlić Jelena , Đerić Teodora , Andrić Luka , Babić Sandra , Šljivančanin Dragiša
Published: October 2023

Introduction/Aim: COVID-19 pandemic posed a challenge in patient treatment and caused problems in the organization of health systems in many countries. The study aimed to analyze and quantify the influence of COVID-19 pandemic on performing surgeries for benign adnexal conditions with classic (open abdominal) and minimally invasive (laparoscopic) approach at the Clinic for Gynecology and Obstetrics University Clinical Center of Serbia. Material and Methods: The study retrospectively analyzed all patients who were operated due to benign adnexal masses at our Clinic during the past five years. We compared numbers and types of operations before and during the pandemic. Results: The study included 2166 patients who significantly more often had laparoscopic (61.9%) than open surgeries (38.1%). Surgeries of benign adnexal masses were elective in 53.2% cases, whereas in 46.8% cases those were emergency surgeries. Before the pandemic laparoscopic surgeries (mostly cystectomies) were on the rise. A reduction in laparoscopic and open surgeries was seen in the year 2020 (p=0.001). Moreover, the majority of surgeries were emergency surgeries (76.2%; p=0.001). Nevertheless, this decrease was significant only for laparoscopic cystectomies (p=0.001), but not for adnexectomies (p=0.224) and salpingectomies (p=0.762). Likewise, the 2020 reduction in open cystectomies (p=0.073), adnexectomies (p=0.836) and salpingectomies (p=0.241) was not significant either. During 2021, the number of surgical procedures for benign adnexal masses started to rise again (p=0.023). No intra-hospital COVID-19 infections were registered. Conclusion: The total number of operations of benign adnexal masses in our Clinic decreased and was limited to emergencies, which was mostly reflected in minimally invasive surgery.
Antenatal corticosteroids: Between being a useful drug and posing a risk for fetal and adult development
Authors: Babović Ivana , Dotlić Jelena , Sparić Radmila , Anđić Mladen , Bila Jovan , Micić Jelena , Jovandarić Miljana , Plešinac Vera , Plešinac Jovana , Karadžov-Orlić Nataša
Published: October 2023

Antenatal corticosteroid therapy (ACST) is very important in reducing the sequelae of prematurity, respiratory distress syndrome (RDS), intraventricular hemorrhage (IVH), and necrotizing enterocolitis (NEC). This therapy has short-term and long-term neonatal consequences that range from reduced neonatal body weight, brain growth, hypertension, hypoglycemia and obesity to delayed neurological development. In addition to undeniable importance this type of therapy has on fetal maturation, it may also impact programming of fetuses future development and health during childhood and adulthood. ACST must be personalized, as a single course, and determined by indications and assessment of the expected time of delivery, so that the exposure time of the fetus to the effects of endogenous and exogenous steroids is shortened.
Complex karyotype in chronic lymphocytic leukemia
Authors: Antić Darko , Kozarac Sofija , Tomić-Vujović Kristina , Otašević Vladimir , Pešić Andrej , Vuković Vojin , Mihaljević Biljana
Published: October 2023

Chronic lymphocytic leukemia (CLL) is a genetically heterogeneous disease with chromosomal and genomic aberrations found in more than 80% of patients, either by conventional or by molecular cytogenetics. Complex karyotype (CK) is defined as the presence of ≥ 3 structural or numerical aberrations in the same clone of CLL malignant cell and is considered a potential prognostic parameter in CLL. The detection of CK in CLL patients can potentially affect prognosis and treatment, considering that CK is associated with the progression of HLL and a worse prognosis, as well as with a higher risk of developing Richter transformation. This review will assess the complexity of karyotype analysis in CLL and its prognostic importance and implications.
Differences in physical activity of adolescents of different sexes between 12 and 15 years old on different days of week
Authors: Štemberger Vesna , Petrušič Tanja
Published: October 2023

Achieving the recommended daily level of physical activity (PA) in adolescent boys and girls helps improve their cardiovascular health, maintain a healthy body weight, and promote mental health. The purpose of our study was to determine whether there were statistically significant differences between boys and girls aged 12 to 15 years with respect to age and amount of PA on different days of the week. The sample included 606 7th, 8th, and 9th grade students from four Slovenian elementary schools who participated in the study by completing a questionnaire (IPAQ; International Physical Activity Questionnaire, 2006). We used a quantitative research approach and the method was causal-non-experimental. The Shapiro-Wilk test was used to determine whether the data were normally distributed at a statistically significant level of risk (p > 0.05). Because of the non-normal distribution of the variables (p < 0.001), the non-parametric Mann-Whitney test was used to determine statistically significant differences between genders, and the Kruskal-Wallis test was used to determine statistically significant differences between age groups. Boys were statistically significantly more active than girls on all days of the week except Wednesday (Mon.: p=0.018; Tues.: p=0.001; Thurs.: p=0.020; Fri.: p=0.015, Sat.: p=0.012; Sun.: p=0.001). Significant differences in PA levels between seventh-, eighth-, and ninthgraders occurred only on Sundays (p<0.001), with PA levels changing with student age. The study's findings that adolescent boys are statistically significantly more active than girls raise concerns about gender differences in PA participation during this critical developmental period. Such differences may contribute to long-term health consequences and perpetuate gender inequalities in overall fitness and well-being. The observed differences in PA between boys and girls during adolescence highlight the need for targeted interventions and strategies to promote and improve PA among girls. Addressing the underlying factors that contribute to lower activity levels among girls is essential to promoting a more equitable and inclusive approach to PA promotion.
Unbreakable bonds: Serbian architects and the military (19th-21st century)
Authors: Kadijević Aleksandar
Published: October 2023

From the 19th century uprising period to the present day, Serbia has witnessed a controlled militarization of urban areas as part of its defense policy, with the army showcasing its fighting spirit and emphasizing its crucial role in the public security system. During peacetime, this process unfolds gradually and inconspicuously as 'peacetime protective' measures, but escalates during political crises and wars. The devastating war conflicts, resulting from geopolitical and regional crises that often spilled into Serbia's territory over the last two centuries, have had adverse effects on both military and civil infrastructure. Beyond architecture, which holds significant communicative importance, this militarization has also impacted other aspects of visual culture. Military facilities, as a means of controlling public spaces, have assumed a prominent position in Serbian cities' symbolic topographies, often occupying main squares. Their construction is coordinated with the strategies of the Ministry of the Army's (or Defense) strategies, general urban plans and Serbia's spatial development. However, conflicts between architects and military institution managers often arose during implementation, with architects striving for adherence to planned solutions and artistic visions, while clients sought adaptation to current security needs. Despite developing in a more modest form compared to major world powers, Serbia's militarization of public spaces continues to merit critical examination. Beyond the architecturally-urban perspective dominant in scientific historiography, military complexes warrant a more comprehensive analysis from a security standpoint and as a legacy of a distinct military visual culture, influenced by military hierarchy dynamics and the country's changing geopolitical position. Thus, increased openness of military institutions to research their architectural past and improved collaboration between architectural and military historians could effectively address existing knowledge gaps.
Metaarchitecture of Predrag Ristić: Bridging non-philosophy and hypermetaphysics
Authors: Stevanović Vladimir , Ciganović Aleksa
Published: October 2023

This paper aims to research, critically interpret and synthesize the metaarchitectural work of Dr. Predrag Ristić, a Serbian and Yugoslav architect and artist (1931-2019). The focus is on Ristić's production of meta-architecture, exploring his role as an engaged individual who intervenes in an intellectually dissident manner beyond official academic institutions, while contributing to the cultural liberalization within the social context of the Yugoslav paradigm during the second half of the twentieth century. Metaarchitecture, in this sense, can be seen as a broader semiological construct encompasing the ability and will to create ontological signs, epistemological events or methodological objects that extend beyond the architectural domain into the realms of art and culture, shaping forms of social history and criticism. The analysis of Ristić's work will be carried out in two distinct directions, reflecting two phases of his creative activity, each associated with specific theoretical paradigms. Ristić's earlier phase during the 1960s and 1970s, marked by a techno-pessimistic and techno-critical observation of the world (from the Kajmakčalan church to several Thanatopolis projects), is analytically linked to non-philosophy as an anti-dogmatic phenomenological concept. On the other hand, his later creative aspirations from the 1980s are interpreted through his semioanthropological approach to the Mesolithic culture of Lepenski Vir, a subject of his PhD thesis, which connects to hypermetaphysics as a comparative conceptual formation.
Texts by Stevan Pešić for puppet and drama theater for children: A critical reception in the 1970s and 1980s: Contributing to the research of Pešić's dramaturgy
Authors: Šarančić-Čutura Snežana
Published: October 2023

This study explores the critical reception of Stevan Pešić's numerous texts written for puppet and drama theater for children, such as Legenda o Bošku Buhi, Vesela kuća, Guska na Mesecu, Jedne noći u Novome Sadu, Grad sa zečjim ušima, Krilata krava, Ptice, Lovačka priča, Ništa bez konja, Pet mesečevih cvetova, Braća Grim, Pinokio, Mocart i kompanija, Priča o repi, Čudno čudo, Velimir i Bosiljka, Čudesni vinograd, Bor visok do neba, Petao sa repom duginih boja, Plava ptica, and more. Many of these works were performed on stages across Yugoslavia, some were published, awarded, and even translated, emphasizing Pešić's significant influence in the literary and artistic expression of the second half of the 20th century. Through an analysis of critical comments published in periodicals and other sources during the 1970s and 1980s, this study highlights various opinions on Pešić's texts, including their communicativeness with children, his dramaturgical skill, and his poetic style, which encompassed elements of surrealism, the miraculous, fairytales, grotesque, absurdity, and dreamlike qualities. Examining how critics perceived Pešić's work becomes a crucial aspect of identifying and evaluating the key features of his dramaturgy, determining his place in literary and theatrical trends, and understanding his writer's originality. Moreover, the reception horizon provided by these critical assessments serves as an incentive for further research into Pešić's contributions, the broader tendencies in puppet and drama art for children, and the approaches adopted by the critics who engaged with it.
A novel decision-making approach based on interval-valued T-spherical fuzzy information with applications
Authors: Nazeer Muhammad Safdar , Ullah Kifayat , Hussain Amir
Published: October 2023

Multi-attribute group decision-making (MAGDM) is very significant technique for selecting an alternative from the provided list. But the major problem is to deal with the information fusion during the information. Aczel-Alsina t-norm (AATN) and Aczel-Alsina t-conorm (AATCN) are the most generalized and flexible t-norm (TN) and t-conorm (TCN) which is used for information processing. Moreover, the interval-valued T-spherical fuzzy set (IVTSFS) is the latest framework to cover the maximum information from the real-life scenarios. Hence, the major contribution of this paper is to deal the information while the MAGDM process by introducing new aggregation operators (AOs). Consequently, the interval-valued T-spherical fuzzy (IVTSF), Aczel-Alsina weighted averaging (IVTSFAAWA), IVTSF Aczel-Alsina (IVTSFAA) ordered weighted averaging (IVTSFAAOWA), IVTSFAA weighted geometric (IVTSFAAWG), IVTSFAA ordered weighted geometric (IVTSFAAOWG), and IVTSFAA hybrid weighted geometric (IVTSFAAHWG) operators are developed. It is shown that the proposed operators are the valid and the results obtained are reliable by discussing some basic properties. To justify the developed AOs, an example of the MAGDM is discussed. The sensitivity of these AOs is observed keeping in view of the variable parameter. To show the importance of the newly developed theory, a comparison of the proposed AOs is established with already existing operators.
Klasifikasi Spesies Hiu Dengan Arsitektur
Authors: Bahar Ahmad , Bagus Adhi Kusuma
Published: October 2023

Ikan hiu adalah kelompok hewan yang menarik dan menakutkan di dunia laut. Mereka termasuk dalam kelas Chondrichthyes bersama dengan pari dan hiu bersirip. Mereka dapat ditemukan di berbagai perairan dan memiliki peran penting sebagai indikator kesehatan ekosistem laut. Namun, populasi ikan hiu terancam karena penangkapan ikan ilegal dan kurangnya konservasi. Dalam proses mengidentifikasi dan mengklasifikasikan spesies hiu, peneliti membuat program dengan menggunakan teknik pengenalan visi komputer, seperti Convolutional Neural Network (CNN), dapat sangat membantu. Salah satu arsitektur CNN yang efektif adalah ResNet50, yang terbukti berhasil dalam klasifikasi gambar. Dengan menggunakan 4720 data citra ikan hiu dari 14 kelas model ResNet50 berhasil mencapai akurasi 86% dalam klasifikasi spesies ikan hiu. Model ini dapat digunakan untuk mengidentifikasi spesies hiu dengan baik, kecuali pada beberapa kelas tertentu yang perlu diperbaiki.
Bahasa Kebijakan Basuki Tjahaja Purnama (Ahok) yang Menjadi Kontroversi (Kajian Linguistik Forensik)
Authors: Nesti Meksi Rahma , Afrianti Desi
Published: October 2023

Kebijakan yang diambil Ahok menjadi kontroversi. Apakah bahasa kebijakan Ahok yang menjadi kontroversi disusupi oleh pelaku kejahatan? Mengapa kebijakan tersebut tidak berjalan sesuai dengan yang diharapkan oleh kebijakan itu sendiri? Mengapa masih banyak isu serta konflik yang terjadi di lapangan setelah kebijakan itu diambil? Oleh sebab itu, linguistik forensik hadir untuk memecahkan masalah tersebut. Artikel ini menggunakan analisis proyeksi pada pikiran kebijakan ketika dibenturkan dengan faktor-faktor, serta menggunakan pendekatan kualitatif deskriptif. Hasil analisis bahasa kebijakan yang dikeluarkan Ahok, bisa dikatakan bahwa kebijakan-kebijakan yang dikeluarkan termasuk tindakan yang berpola kejahatan atau telah terjadi penyusupan terhadap kebijakan yang dikeluarkannya. Bisa jadi, kebijakan yang dikeluarkan Ahok adalah untuk dirinya sendiri atau untuk masyarakat dari kalangan menengah ke atas. Sebab, pada kebijakan (1), (2), (3), maupun (4) ditujukan untuk kalangan tertentu dan kelompok tertentu. Pada kebijakan (1) dan (4) tentu dikhususkan pada kalangan menengah kebawah yang tidak sanggup membeli mobil dan pengunjuk rasa yang merasa dirugikan oleh Gubernur DKI Jakarta. Sedangkan, pada kebijakan (2) ditujukan pada umat Islam, yang pada waktu itu akan memasuki hari raya Idul Adha. Selanjutnya, kebijakan (3) untuk para pejabat yang berada dibawah pimpinan/pemerintahan Ahok yang bisa dibongkar pasang/diganti-ganti layaknya mainan/mesin.
Pendekatan Pemecahan Masalah Matematika dalam Meningkatkan Hasil Belajar Matematika Siswa
Authors: Ahmad
Published: October 2023

Meskipun pentingnya matematika telah diakui secara luas, masih banyak siswa yang mengalami kesulitan dalam memahami konsep-konsep matematika dan mencapai hasil belajar. Penggunaan pendekatan pemecahan masalah dalam pembelajaran matematika dapat meningkatkan pemahaman konsep dan hasil belajar siswa kelas VII B SMP Negeri 2 Pancarijang tahun 2015/2016. Jenis penelitian ini adalah penelitian tindakan kelas (classroom action research) dengan dua siklus. Setiap siklus terdiri dari tahapan yang sama yakni, perencanaan, pelaksanaan tindakan, observasi, evaluasi dan refleksi. Data penelitian ini berupa data hasil belajar dan data tentang proses belajar mengajar. Penerapan pembelajaran dengan pendekatan pemecahan masalah dapat meningkatkan perhatian dan motivasi belajar siswa serta hasil belajar matematika siswa. Skor rata-rata hasil belajar matematika pada siklus I sebesar 67,84% dan pada siklus II sebesar 77,40% atau ada peningkatan sebesar 9,56%.atau indikator lainnya dapat dilihat pada siklus I masih terdapat 9 atau setara dengan (28,13%) orang siswa yang tidak tuntas, tetapi pada siklus II sudah tidak ada lagi siswa yang tidak tuntas.
A Hidden Success
Authors: Ziebritzki Catharina
Published: October 2023

Following the EU General Court’s dismissal of the complaint of WS and other asylum seekers against Frontex in its ruling on September 6, 2023, scholarly commentary has largely expressed disappointment. However, a more optimistic way of reading the judgement is also possible. By declaring the lawsuit admissible, the court confirmed that factual misconduct by Frontex can be addressed with action for damages claims – and this in itself is a major step forward in the system of fundamental rights protection in the European Union.
Performance and Genetic Evaluation of Okra (Abelmoschus esculentus (L.) Moench) Genotypes for Agromorphological Traits
Authors: Farooqkhan Pattan , Rajan R. Ebenezer Babu , Kumar C. Praveen Sampath , Ruban J. Sam
Published: October 2023

Okra or Bhendi is a crucial vegetable farmed in India. The state of Tamil Nadu contains a smaller cultivable area and less okra production. As a result, the investigative study was conducted at Sivapuri, Chidambaram, Tamil Nadu to estimate variability metrics such as PCV, GCV, and GA% mean for crop advancement studies. The experiment involved 48 okra genotypes and 12 qualitative variables. In accordance with ANOVA, the mean sum of squares of 48 genotypes was highly significant for all parameters tested. For the twelve studied traits, values of PCV was higher than values of GCV by a little margin, showing the influence of environmental influences on genotypes. High heritability was found in all characters except days to 50% flowering and days to first harvest. High genetic advance % of mean was perceived in all the traits except for days to the 50% flowering, the harvest period and days to first harvest. High heritability combined with high GA was recorded in traits like primary branches per plant, fruit girth, no. of fruits per plant, fruit length, and fruit yield per plant. If genotypes are chosen based on these traits, selection for genetic improvement programs would be highly efficient.
Studies on Biochemical Changes in Immature Mangoes (Mangifera indica L.) cv Konsam Heinou of Manipur using Different Skin Coatings During Storage
Authors: Singh Ram Preet , Piloo Ng. , Yadav Shweta , Singh Konthoujam James
Published: October 2023

The present investigation on “Studies on Biochemical Changes in Immature Mangoes (Mangifera indica L.) cv Konsam Heinou of Manipur Using Different Skin Coatings during storage” was carried out during month of May-June of the year 2021 at Post Graduate Laboratory, Department of Horticulture, College of Agriculture, Central Agricultural University, Manipur. Freshly collected uniform sized mango fruits were picked, washed, cleaned and treated in the laboratory with various coatings, including castor oil (T1), palm oil (T2), coconut oil (T3), mustard oil (T4), aloevera gel (T5), paraffin wax (T6), cling film (T7), and no coating (T8). The experiment was framed in CRD (Completely Randomized Design) and repeated 3 times with 7 treatments and an uncoated treatment. The results obtained from the current investigation on biochemical changes in quality parameters the fruits treatments with cling film (T7) had minimum TSS, TSS : Acid ratio, reducing sugar and total sugar content with maximum acidity content while fruits coating with paraffin wax (T6) and cling film(T7) had maintaining of chlorophyll content up to 15th days of storage under ambient condition.
Nano-priming with zinc and boron enhances seed germination and seedling vigour in sunflower (Helianthus annuus L.)
Authors: Biradar Santosh , Nagarathna T. K. , Praveen H. G.
Published: October 2023

Nanotechnology is a broad and interdisciplinary area of research and development activity that has been growing at a rapid pace worldwide in the past few years. Recent manufacturing advancements have led to the fabrication of nanoparticles of different sizes and shapes. The new dimension in improving nutrient use efficiency is the use of nanoparticles which are used extensively in a wide range of sectors. Most investigations so far have focused on cereals and a very few studies have been done in sunflower. Hence, an attempt was done to standardize the concentration and soaking period by treating sunflower hybrid seeds with nano zinc and nano boron based on germination percentage and seedling vigour. The results showed that nano zinc @100ppm and nano boron @50ppm for one and a half hour soaking period significantly enhanced germination, higher seedling length with noticeably more secondary and tertiary roots over control and bulk nutrients and seedling vigour and there were no significant results at higher concentrations and longer soaking period. The use of nano nutrients can reduce the burden of excess zinc and boron fertilizer to soil.
Impact of Sal (Shorea robusta) ANR (Assisted Natural Regeneration) in Shiwalik Forests of Uttarakhand
Authors: Singh Vedpal , Dhawan V. K. , Negi Anmol , Kumar Prabal
Published: October 2023

Along with other valuable tree species, Sal is the predominant forested crop in the Shiwalik Circle of the Doon valley. It has been observed that the stock of Sal forests is quickly running out. The influence of Sal ANR (Assisted Natural Regeneration) was investigated in 10 forest ranges of the Shiwalik circle of the Uttarakhand forest department, India, keeping in mind the importance of this tree species. For the purpose of gathering field data that spanned the entirety of the compartment, random sampling was used. For comparison, data from two compartments, Sal ANR and non-ANR (next to ANR), were gathered. Various conclusions were drawn according to the study.
ACTIVITIES OF THE PARLIAMENTARY ASSEMBLY OF THE COLLECTIVE SECURITY TREATY ORGANIZATION ON HARMONIZATION OF LEGISLATION IN THE FIELD OF MIGRATION POLICY AND COUNTERING ILLEGAL MIGRATION
Authors: Bondurovsky Vladimir , Pospelov Sergey
Published: October 2023

A description of the activities of the Parliamentary Assembly of CSTO on migration policy and countering illegal migration from 2010 to 2022 is given. The relevance of the parliamentary dimension of migration policy within the CSTO is confirmed by the situation that develops almost along the entire perimeter of the borders of the CSTO member states. The adopted recommendations on harmonizing the legislation of the CSTO member states in the areas of countering illegal (irregular) migration and human trafficking (2011) are covered; problems of refugees and asylum seekers (2014); creating a positive image of labor migrants (2015); qualifications of acts for various types of human trafficking (2016); pension provision for labor migrants (2016), blocking the channels of international terrorism (2022). The prospects for the rule of law of the CSTO member states in the field of migration security for 2024–2025 are outlined. Recommendations are being developed in the field of combating illegal migration and the Concept of Migration Security of the CSTO member states.
ON THE ISSUE OF THE PROBLEMS OF LEGAL REGULATION OF DIVING OPERATIONS IN EMERCOM OF RUSSIA
Authors: Shenshin Victor
Published: October 2023

The issues of rulemaking in the Russian diving industry in recent years have the greatest relevance, however, as in many other industries, they lag behind the existing reality. The presented study analyzes the problems of legal regulation of diving operations carried out in EMERCOM of Russia.

The conclusion is made about the insufficiency of legal regulation of these works. Attention is focused on the need to develop a Federal law «On the legal regulation of diving operations in the Russian Federation». To date, there is a need to create a new system of training and training of diving personnel in the Russian Federation, to develop a basic program for training and advanced training of professional divers according to uniform standards for each category. The reasons for the insufficiently high result of standard-setting activities in diving in Russia are indicated.
In-Vitro Evaluation of Antiulcer Activity of Ethanol Extract of Saponaria Officinalis
Authors: Ms. Sowmya B.A  , Dr. Satish Pavuluri
Published: October 2023

For the treatment and prevention of illnesses and disorders, medicinal plants are recognized to contain conventional therapeutic substances. This study examined the potential of ethanol extracts of Saponaria officinalis to block H+/K+ ATPase and neutralize acids in order to determine whether they may be utilized to cure ulcers. In traditional medicine, the Saponaria officinalis is used to treat gastrointestinal disorders and inflammation. The acidity of the extract at a 1500 mg/ml concentration was much lower than that of conventional aluminium hydroxide + magnesium hydroxide (500mg), falling to 5.33 from 12.7. The ethanol extract of Saponaria officinalis at a concentration of 100μg, showed maximum percentage of inhibition of 67.17±1.96% as compared to omeprazole 71.47±0.52%, demonstrated the highest percentage of inhibition of the H+/K+ - ATPase. The results of this study suggest that Saponaria officinalis ethanol extract contains substances that can block enzymes and neutralize acids, making it a potential alternative treatment for digestive issues.
Synthesis, Characterisation and Anticancer Study of Acridine derivatives
Authors: Herole R A  , Rakesh Kumar Jat
Published: October 2023

Cancer is one of the global problem and a major cause for mortality. many treatment strategies are available for cancer treatment, still there is a scope for novel treatment to avoid serious side effects of existing therapy. Novel DNA binding agents are needed for effective treatment of cancers. In the field of antitumor DNA-intercalating agents, 9-aminoacridines play an important role due to their antiproliferative properties. Several cancer chemotherapeutics such as amsacrine and nitracrine have been developed as anticancer agents.In present study, a series of new acridine-based derivatives numbered 3a–3j were synthesized and their anticancer activity against A549 (Human, small cell Lung Carcinoma) cell line was evaluated by MTT Assay. Out of the screened compounds, compound 3b exhibited potent anticancer activity with IC50 78.04 µg/ml for lung cancer cell (A-549) line.Further in vivo study of newly synthesized acridine derivative can explore a ray of light in the field of anticancer drugs.
Blood Report Analysis-A Review
Authors: Gajbhiye Sanghadeep , Aate Jayshree
Published: October 2023

To determine your general health status; to screen for, diagnose, or monitor any one of a variety of diseases and conditions that affect blood cells, such as anemia, infection, inflammation, bleeding disorder or cancer. The complete blood count (CBC) is a group of tests that evaluate the cells that circulate in blood, including red blood cells (RBCs), white blood cells (WBCs), and platelets (PLTs). The CBC can evaluate your overall health and detect a variety of diseases and conditions, such as infections, anemia and leukemia. Blood cells are produced and mature primarily in the bone marrow and, under normal circumstances, are released into the bloodstream as needed.
Mengevaluasi Prediksi Kebangkrutan Melalui Analisis Rasio Keuangan dan Metode Altman Z-Score Pada Perusahaan Farmasi Tahun 2019-2022
Authors: Kusmindian Daryani Ratna , Herdina Nova
Published: October 2023

Tujuan : dari penelitian ini ialah untuk meramalkan, menganalisis, dan mengidentifikasi potensi kemungkinan kebangkrutan sebuah perusahaan dengan menggunakan analisis rasio keuangan dan metode Altman Z-Score pada perusahaan di bidang farmasi dari tahun 2019 hingga 2022 melalui analisis laporan keuangan. Dalam situasi di mana suatu perusahaan menghadapi kebangkrutan, dampak negatif akan dirasakan oleh berbagai pihak. Oleh karena itu, diperlukan suatu model peramalan kemungkinan kebangkrutan yang dapat memberikan indikasi awal kepada perusahaan.
Metodologi : yang digunakan dalam penelitian ini merupakan pendekatan deskriptif berbasis kuantitatif. Data yang digunakan berasal dari sumber sekunder yaitu laporan keuangan. Teknik pengumpulan data yang diterapkan adalah melalui teknik dokumentasi, dan analisis data dilakukan dengan menggunakan pendekatan analisis deskriptif.
Hasil penelitian : menunjukkan bahwa dalam empat tahun terakhir, perusahaan-perusahaan yang diteliti masuk dalam kategori berpotensi menghadapi risiko kebangkrutan. Hal ini disebabkan oleh nilai Z-Score yang dihasilkan pada setiap tahunnya berada di bawah standar yang biasanya berlaku untuk perusahaan-perusahaan dengan kinerja keuangan yang sehat. Penurunan dalam rasio keuangan dan nilai Z-Score ini disebabkan oleh faktor-faktor  beragam, seperti penurunan laba akibat penurunan penjualan, tingginya tingkat utang perusahaan, serta ketidakpastian dalam pengelolaan modal kerja yang dihasilkan oleh perusahaan setiap tahunnya.
A new clustering method based on multipartite networks
Authors: Lung Rodica-Ioana
Published: October 2023

The clustering problem is one of the most studied and challenging in machine learning, as it attempts to identify similarities within data without any prior knowledge. Among modern clustering algorithms, the network-based ones are some of the most popular. Most of them convert the data into a graph in which instances of the data represent the nodes and a similarity measure is used to add edges. This article proposes a novel approach that uses a multipartite network in which layers correspond to attributes of the data and nodes represent intervals for the data. Clusters are intuitively constructed based on the information provided by the paths in the network. Numerical experiments performed on synthetic and real-world benchmarks are used to illustrate the performance of the approach. As a real application, the method is used to group countries based on health, nutrition, and population information from the World Bank database. The results indicate that the proposed method is comparable in performance with some of the state-of-the-art clustering methods, outperforming them for some data sets.
Role of αV integrins in the cellular response of fibro/adipogenic progenitors to lysophosphatidic acid
Authors:   , Cruz Soca Meilyn
Published: October 2023

La fibrosis se caracteriza por la acumulación excesiva de componentes de la matriz extracelular (ECM) en respuesta al daño o patología. La ECM reemplaza el tejido funcional por tejido conectivo, comprometiendo la arquitectura y función de este. En el músculo esquelético, la fibrosis se asocia principalmente con distrofias musculares, incluida la distrofia muscular de Duchenne (DMD). Los progenitores fibro/adipogénicos (FAPs) son una población de células progenitoras mesenquimales, no miogénicas, que poseen un potencial fibrogénico y adipogénico intrínseco. En condiciones patológicas y crónicas, como la DMD, los FAPs se activan a través de la proliferación y diferenciación a miofibroblastos, las principales células secretoras de ECM, causando la infiltración intramuscular del tejido fibroso. Algunas proteínas de la ECM incrementadas, como fibronectina y periostina, son reconocidas por integrinas αv, reguladores clave de la fibrogénesis en una amplia gama de modelos. El ácido lisofosfatídico (LPA) es un lisofosfolípido que señaliza a través de seis receptores acoplados a proteína G (LPARs). Señalización aberrante del LPA se ha relacionado con varias patologías fibróticas, como la fibrosis dérmica, pulmonar idiopática y hepática. Además, LPA induce la expresión del factor de crecimiento de tejido conectivo (CTGF/CCN2), factor pro fibrótico fuertemente relacionado con la patogénesis de trastornos fibróticos como la DMD. Esta evidencia sitúa al LPA como un potente modulador de la fibrosis en diferentes tejidos. Sin embargo, se desconoce el rol del LPA en el músculo, lo cual hace atractivo su estudio en el desarrollo de fibrosis en el músculo esquelético.
Rol de Exo70 en el tráfico polarizado de proteínas asociadas a la migración de linfocitos B
Authors:   , Goles Varela Nicolás Ignacio
Published: October 2023

Los linfocitos B son células fundamentales del sistema inmune adaptativo, donde su desarrollo, maduración y activación están estrechamente ligados a su capacidad migratoria. La migración celular depende de una distribución asimétrica de moléculas de señalización, factores que promueven la remodelación del citoesqueleto de actina, como Arp2/3. Estudios de los mecanismos de tráfico intracelular asociados a migración han identificado que el exocisto, un complejo compuesto por 8 proteínas inicialmente descrito como regulador de la secreción y tráfico vesicular, tiene un importante rol en migración celular. En esta tesis evaluamos el rol de una proteína que forma parte del complejo exocisto, Exo70, y su relación con la migración de los linfocitos B, que hasta ahora no había sido explorado en estas células. Para abordar este estudio sometimos una línea celular de linfocitos B a ensayos funcionales de migración 2D y 3D donde encontramos que la migración de estas células depende de Exo70 mas no de otra subunidad del exocisto, Sec8. Adicionalmente evaluamos el ensamblaje del complejo y la ubicación subcelular de Exo70 en respuesta al estímulo migratorio. Por último, determinamos que Exo70 es fosforilado río abajo de la señal del receptor del estímulo migratorio y mostramos cómo esta promueve la interacción física de Exo70 con el complejo de ramificación de filamentos de actina Arp2/3. En esta tesis mostramos que Exo70 tiene un rol en la migración de linfocitos B, proceso fundamental para la búsqueda de antígenos, activación y posterior maduración de este tipo celular.
Association of Serum Vitamin D3 Levels with the Severity of Acne Vulgaris in Adolescents: A Cross-sectional Study from Western Odisha, India
Authors: Das Kuldip , Bhoi Sanghamitra , Bhoi Sumitra , Pandey Mamata
Published: October 2023

Introduction: Vitamin D3 plays an important role in the immune system, and its deficiency has been implicated in various skin diseases, including atopic dermatitis and psoriasis. Acne is a common inflammatory skin disease of adolescence and young adulthood that affects the face and upper trunk. The scarring caused by acne can have a significant psychological impact on patients and greatly affect their quality of life. However, the association between the severity of acne and vitamin D3 levels remains unclear. Aim: To assess the role of vitamin D3 in the severity of acne vulgaris in adolescents. Materials and Methods: This prospective cross-sectional study was conducted at the Department of Dermatology and Biochemistry, VIMSAR, Burla, Sambalpur, Odisha, India, from August 2022 to November 2022. Adolescents between the ages of 10 and 19 years, of either sex, with acne were clinically examined, and the severity of acne was evaluated using the Global Acne Grading System (GAGS) score. Serum vitamin D3 levels were measured using a Chemiluminescence Immunoassay (CLIA) analyser (Electra FA). Statistical analysis was performed using Statistical Package for the Social Sciences (SPSS) software version 21.0 (SPSS IBM Corporation, Armonk, New York), and a p-value <0.05 was considered statistically significant. Results: A total of 150 clinically diagnosed cases of acne vulgaris patients were evaluated. The study included 73 males and 77 females. The mean age of males was 19.1±2.3 years, and for females, it was 18.2±2.4 years. Serum vitamin D3 levels were lower in patients with severe acne (18.03 ng/mL) compared to those with moderate acne (23.57 ng/mL) and mild acne (28.02 ng/mL). The association between serum vitamin D3 concentration and the different degrees of acne vulgaris was statistically significant (p<0.05). There was a strong negative correlation between severe acne and serum vitamin D3 levels (r=-0.042, p-value=0.002). Conclusion: Vitamin D3 deficiency was more prevalent in patients with severe acne, and serum vitamin D3 levels were inversely correlated with the severity of acne vulgaris.
Design of newly developed burner rig operating with hydrogen rich fuel dedicated for materials testing
Authors: Nowak Wojciech J. , Drajewicz Marcin , Góral Marek , Smusz Robert , Cichosz Piotr , Majka Andrzej , Sęp Jarosław
Published: October 2023

The main purpose of present article is to present the burner rig station newly developed at the Rzeszow University of Technology in Poland. The burner rig is dedicated to operate on fuels rich in hydrogen. The burner rig is able to operate with fuels with hydrogen content up to 50 volume %. A detailed description of burner rig construction is presented. Moreover a mathematical model predicting temperature distribution within the combustion chamber is presented. The obtained results showed a good insulation of burner rig construction leading to the temperature gradient from 1674℃ in the burner rig to 214℃ on steel housing.
Effect of PGRs on Cucurbits: An Overview
Authors: Rajbhar Priyanka , Gurumurthy N.  , Faruk Mohd , Singh Anil Kumar , Singh Shivam Kumar
Published: October 2023

Cucurbits, a popular vegetable, can thrive in deserts and moist tropics. The family Cucurbitaceae contains 118 genera and about 825 species. These crops are mostly grown in India during the summer and rainy seasons, with certain southern and western regions cultivating them in winter. These crops are annual and perennial. PGRs in cucurbits have shown promise in improving crop growth, productivity, and quality. PGRs affect several physiological and developmental processes in cucurbits. There are different effects of the various kind of the PGRs in cucurbits such as watermelon with 25-50 ppm GA3 yielded earlier and more fruits. Fruit count rose with 250 and 500 ppm ethrel. The 40 ppm GA3 increased vegetative growth and production. TIBA (20 ppm) increased fruit weight and yield. In case of cucumber GA3 at 20 ppm and NAA at 100 ppm increased cucumber growth and production. Application of GA3 (20 ppm) at the 4-leaf stage enhances growth, flowering, and yield in bottle gourd. In bitter gourd fruit per plant, fruit weight, and yield increased significantly with GA3 at 60 ppm. Ethrel at 50 ppm improved fruit set and weight. Gibberex treatments increased fruit quantity, weight, and yield per plant. Further study and fieldwork are needed to understand PGRs and determine the appropriate effects for cucurbits.
Impact of Export Diversification on Economic Growth in Sub-Saharan Africa (SSA)
Authors: Ajayi Kayode Johnson
Published: October 2023

This study investigated the impact of export diversification on the economic growth of countries in Sub-Saharan African (SSA). Trade Data are gathered from the World Integrated Trade Solution (WITS), and UN Comtrade database, using a 6-digit level range of the Standard International Trade Classification (SITC) and the Harmonised System (HS) for the Countries. Export diversification Indices data are proxies from the Herfindahl Hirschman Index (HHI) which represents the level of export product diversification for all forty-eight (48) SSA Countries between 1995 and 2020. The Panel Autoregressive Distributed Lagged Model (P-ARDL) was applied in the study. Other analysis including correlation analysis, multicollinearity, and Unit Root tests were used to achieve the objective of the study. The findings showed that export diversification has not really benefitted the SSA Countries; also, exporting raw materials and other primary products does not benefit the region, and therefore, the countries should continue leveraging on the potential of diversifying their exports and exploring sectors such as the manufacturing to attain more economic gains. To achieve export gains, oil/minerals products should be exported as finished products, not as raw materials, especially, from those nations that are resources endowed. These raw materials should be best used domestically to aid production into finished/refined products for subsequent exports.
HUMAN vs. ROBOT: THE APPLICATION OF SMART TECHNOLOGY IN THE HOTEL INDUSTRY
Authors: Putri Raditya Nafisa Purnomo , Situmorang Ringkar , Mehrotra Amit
Published: October 2023

The current use of robotics, artificial intelligence, and service automation (RAISA) illustrated that innovation developed very quickly and had an enormous impact on how consumers use tourism services. This study aimed to determine how tourism and hospitality employees dealt with the pandemic, particularly when implementing the protocol called physical distance in the new normal era. This study also intended to discover our hospitality industry's readiness to confront a new normal era by applying technology to serve guests. This study conducted semi-structured interviews with 15 stakeholders. The findings indicated that the government and hotel management exploit this occurrence to enhance service quality, explicitly emphasizing hotel consumer comfort and safety. It was posited that the issues associated with the interaction between humans and robots extend beyond budgetary considerations, readiness, and maintenance. A crucial aspect to consider was robots' potential replacement of service uniqueness, particularly in developing countries. Integrating robotics and artificial intelligence (AI) inside the hotel industry may need to reevaluate the hospitality and tourism education curriculum.
Hospital Equity Rating Metrics—Promise, Pitfalls, and Perils
Authors: Golden Sherita Hill , Powe Neil R.
Published: October 2023

This Viewpoint addresses several considerations regarding equity metrics across hospital regulatory and accrediting organizations and suggestions for improvement.
Suicide Ideation, Plans, and Attempts Among Military Veterans vs Nonveterans With Disability
Authors: Blais Rebecca K. , Xie Zhigang , Kirby Anne V. , Marlow Nicole M.
Published: October 2023

Importance

People with disability are at heightened risk for suicide ideation, planning, and attempt, with risk growing as the number of disabling limitations increases. Military veterans have higher rates of suicide deaths and disability relative to nonveterans.

Objective

To evaluate whether veteran status is associated with greater risk for suicide in those with disability.

Design, Setting, and Participants

This survey study used cross-sectional self-reported data from US adults who participated in the 2015-2020 National Survey on Drug Use and Health. Data were weighted to represent the population. Data analysis was conducted from July to August 2022.

Main Outcomes and Measures

Suicide ideation, planning, and attempt served as primary outcomes. Disability status (present or absent) and number of disabling limitations (1, 2, or ≥3) served as factors. Veteran status was determined based on self-report (veteran or nonveteran). Multivariable logistic regression examined suicide ideation, planning, and attempt as a function of veteran status and disability variables.

Results

Participants included 231 099 US veterans and nonveterans, representing 236 551 727 US adults, of whom 20.03% (weighted n = 47 397 876) reported a disabling limitation, 8.92% were veterans (weighted n = 21 111 727; 16.0% aged 35-49 years; 91.0% men; 6.7% Hispanic; 10.9% non-Hispanic Black; and 78.4% non-Hispanic White) and 91.08% were nonveterans (weighted n = 215 440 000; 25.4% aged 35-49 years; 44.0% male; 16.5% Hispanic; 11.7% non-Hispanic Black; and 63.3% non-Hispanic White). Overall, 4.39% reported suicide ideation, planning, or attempt (weighted n = 10 401 065). Among those with no disability, veteran status was associated with higher risk of suicide planning (adjusted odds ratio [AOR], 1.71; 95% CI, 1.17-2.49). Among those with 1 or 2 disabling limitations, being a veteran was associated with a lower risk of suicide planning (AOR, 0.57; 95% CI, 0.34-0.95) and history of attempt (AOR, 0.46; 95% CI, 0.24-0.88).

Conclusions and Relevance

In this study of how suicide risk differs as a function of disability and veteran status, risk for death by suicide was lower among veterans with disability relative to nonveterans with disability. Veteran status may mitigate risk for suicide given increased receipt of more disability-related care through the Department of Veterans Affairs. Further research would extend this line of inquiry by examining the cause and type of disability as well as perceptions of disability on self-worth. It is possible that physical wounds of war are protective because of the meaning and value of service to one’s country.
Location of the photosynthetic carbon metabolism in microcompartments and separated phases in microalgal cells
Authors: Launay Hélène , Avilan Luisana , Gérard Cassy , Parsiegla Goetz , Receveur‐Brechot Véronique , Gontero Brigitte , Carriere Frédéric
Published: October 2023

Carbon acquisition, assimilation and storage in eukaryotic microalgae and cyanobacteria occur in multiple compartments that have been characterised by the location of the enzymes involved in these functions. These compartments can be delimited by bilayer membranes, such as the chloroplast, the lumen, the peroxisome, the mitochondria or monolayer membranes, such as lipid droplets or plastoglobules. They can also originate from liquid–liquid phase separation such as the pyrenoid. Multiple exchanges exist between the intracellular microcompartments, and these are reviewed for the CO2 concentration mechanism, the Calvin–Benson–Bassham cycle, the lipid metabolism and the cellular energetic balance. Progress in microscopy and spectroscopic methods opens new perspectives to characterise the molecular consequences of the location of the proteins involved, including intrinsically disordered proteins.
DEA extends telemedicine for controlled substances until end of 2024
Authors: Knopf Alison
Published: October 2023

Last week the Drug Enforcement Administration (DEA) announced that it would extend exceptions that went into effect at the start of the COVID‐19 pandemic for telemedicine prescribing of buprenorphine. The exceptions, started in March 2020 (see https://onlinelibrary.wiley.com/doi/10.1002/adaw.32664), allow for prescribing buprenorphine even in cases where there is no in‐person medical evaluation and were initially meant to limit the spread of the virus. Now, however, they are discussed as ways to limit the overdose crisis. The proposal applies, moreover, to all controlled substances, not just to buprenorphine.
Study shows growth in overdoses accelerating at lower education levels
Authors: Enos Gary
Published: October 2023

In findings that the author called “glaring” and “startling,” a newly published study documents an association between lower levels of educational attainment and steeper increases in recent drug overdose deaths. The disparities in overdose deaths based on education level have become particularly prominent since 2018, a finding that the investigator has attributed in part to the effects of a dynamic opioid market.