bluuebunny/crossref_metadata_2025 huggingface dataset:
Circulating Tumor Cells: Liquid Biopsy of Cancer
Authors: Alix-Panabières Catherine , Pantel Klaus
Published: September 2012

BACKGROUND

The detection and molecular characterization of circulating tumor cells (CTCs) are one of the most active areas of translational cancer research, with >400 clinical studies having included CTCs as a biomarker. The aims of research on CTCs include (a) estimation of the risk for metastatic relapse or metastatic progression (prognostic information), (b) stratification and real-time monitoring of therapies, (c) identification of therapeutic targets and resistance mechanisms, and (d) understanding metastasis development in cancer patients.

CONTENT

This review focuses on the technologies used for the enrichment and detection of CTCs. We outline and discuss the current technologies that are based on exploiting the physical and biological properties of CTCs. A number of innovative technologies to improve methods for CTC detection have recently been developed, including CTC microchips, filtration devices, quantitative reverse-transcription PCR assays, and automated microscopy systems. Molecular-characterization studies have indicated, however, that CTCs are very heterogeneous, a finding that underscores the need for multiplex approaches to capture all of the relevant CTC subsets. We therefore emphasize the current challenges of increasing the yield and detection of CTCs that have undergone an epithelial–mesenchymal transition. Increasing assay analytical sensitivity may lead, however, to a decrease in analytical specificity (e.g., through the detection of circulating normal epithelial cells).

A considerable number of promising CTC-detection techniques have been developed in recent years. The analytical specificity and clinical utility of these methods must be demonstrated in large prospective multicenter studies to reach the high level of evidence required for their introduction into clinical practice.
Metal release from hip prostheses: cobalt and chromium toxicity and the role of the clinical laboratory
Authors: Campbell Jonathon R. , Estey Mathew P.
Published: September 2012

Individuals with advanced hip disease suffer from pain, impaired hip function, and decreased quality of life. Roughly one million metal-on-metal (MoM) hip prostheses have been implanted worldwide in order to ameliorate these issues. While most MoM hip replacements are successful, some patients suffer from serious adverse effects secondary to the release of metal debris due to implant wear and corrosion. MoM hip prostheses are comprised predominantly of cobalt and chromium, and the serum concentration of these metal ions has been shown to correlate with both implant wear and the accumulation of metal debris in the periprosthetic tissue. Consequently, measurement of cobalt and chromium concentrations may be useful in the assessment of implant function and the potential for adverse effects in the follow-up of patients with MoM hip prostheses. The purpose of this Mini Review is to describe the adverse biological consequences of metal release from hip prostheses, provide an overview of the clinical utility of cobalt and chromium measurement and the current recommendations for testing, and alert laboratorians and physicians to the many challenges associated with measuring these metal ions.
Tonic and Transient Endocannabinoid Regulation of AMPAergic Miniature Postsynaptic Currents and Homeostatic Plasticity in Embryonic Motor Networks
Authors: Gonzalez-Islas Carlos , Garcia-Bereguiain Miguel Angel , Wenner Peter
Published: September 2012

Endocannabinoid signaling has been shown to mediate synaptic plasticity by retrogradely inhibiting presynaptic transmitter release in several systems. We found that endocannabinoids act tonically to regulate AMPA miniature postsynaptic current (mPSC) frequency in embryonic motor circuits of the chick spinal cord. Further, strong postsynaptic depolarizations also induced a short-lived endocannabinoid-mediated suppression of mEPSC frequency. Unlike many previous studies, endocannabinoid signaling was not found to influence evoked transmitter release. The results suggest a special role for spontaneous glutamatergic mPSCs and their control by endocannabinoids in the developing spinal cord. We determined that blocking endocannabinoid signaling, which increases spontaneous glutamatergic release, increased spontaneous network activityin vitroandin vivo. Previous work in spinal motoneurons had shown that reducing spontaneous network activity (SNA) chronicallyin vivoled to homeostatic increases in AMPA and GABA mPSC amplitude (homeostatic synaptic plasticity). Blocking endocannabinoid signalingin vivo, and thus increasing SNA, triggered compensatory decreases of both AMPA and GABA mPSC amplitudes. These findings, combined with previous results, are consistent with the idea that this form of homeostatic synaptic plasticity is a bidirectional process in the living embryo. Together, our results suggest a role for tonic signaling of endocannabinoids as a potential mechanism to regulate the level of SNA, which is known to be critical for synaptic maturation in the embryonic spinal cord.
Form and Function of the M4 Cell, an Intrinsically Photosensitive Retinal Ganglion Cell Type Contributing to Geniculocortical Vision
Authors: Estevez Maureen E. , Fogerson P. Michelle , Ilardi Marissa C. , Borghuis Bart G. , Chan Eric , Weng Shijun , Auferkorte Olivia N. , Demb Jonathan B. , Berson David M.
Published: September 2012

The photopigment melanopsin confers photosensitivity upon a minority of retinal output neurons. These intrinsically photosensitive retinal ganglion cells (ipRGCs) are more diverse than once believed, comprising five morphologically distinct types, M1 through M5. Here, in mouse retina, we provide the first in-depth characterization of M4 cells, including their structure, function, and central projections. M4 cells apparently correspond to ON α cells of earlier reports, and are easily distinguished from other ipRGCs by their very large somata. Their dendritic arbors are more radiate and highly branched than those of M1, M2, or M3 cells. The melanopsin-based intrinsic photocurrents of M4 cells are smaller than those of M1 and M2 cells, presumably because melanopsin is more weakly expressed; we can detect it immunohistochemically only with strong amplification. Like M2 cells, M4 cells exhibit robust, sustained, synaptically driven ON responses and dendritic stratification in the ON sublamina of the inner plexiform layer. However, their stratification patterns are subtly different, with M4 dendrites positioned just distal to those of M2 cells and just proximal to the ON cholinergic band. M4 receptive fields are large, with an ON center, antagonistic OFF surround and nonlinear spatial summation. Their synaptically driven photoresponses lack direction selectivity and show higher ultraviolet sensitivity in the ventral retina than in the dorsal retina, echoing the topographic gradient in S- and M-cone opsin expression. M4 cells are readily labeled by retrograde transport from the dorsal lateral geniculate nucleus and thus likely contribute to the pattern vision that persists in mice lacking functional rods and cones.
NKCC1 Knockdown Decreases Neuron Production through GABAA-Regulated Neural Progenitor Proliferation and Delays Dendrite Development
Authors: Young Stephanie Z. , Taylor M. Morgan , Wu Sharon , Ikeda-Matsuo Yuri , Kubera Cathryn , Bordey Angélique
Published: September 2012

Signaling through GABAAreceptors controls neural progenitor cell (NPC) developmentin vitroand is altered in schizophrenic and autistic individuals. However, thein vivofunction of GABAAsignaling on neural stem cell proliferation, and ultimately neurogenesis, remains unknown. To examine GABAAfunctionin vivo, we electroporated plasmids encoding short-hairpin (sh) RNA against the Na-K-2Cl cotransporter NKCC1 (shNKCC1) in NPCs of the neonatal subventricular zone in mice to reduce GABAA-induced depolarization. Reduced GABAAdepolarization identified by a loss of GABAA-induced calcium responses in most electroporated NPCs led to a 70% decrease in the number of proliferative Ki67+NPCs and a 60% reduction in newborn neuron density. Premature loss of GABAAdepolarization in newborn neurons resulted in truncated dendritic arborization at the time of synaptic integration. However, by 6 weeks the dendritic tree had partially recovered and displayed a small, albeit significant, decrease in dendritic complexity but not total dendritic length. To further examine GABAAfunction on NPCs, we treated animals with a GABAAallosteric agonist, pentobarbital. Enhancement of GABAAactivity in NPCs increased the number of proliferative NPCs by 60%. Combining shNKCC1 and pentobarbital prevented the shNKCC1 and the pentobarbital effects on NPC proliferation, suggesting that these manipulations affected NPCs through GABAAreceptors. Thus, dysregulation in GABAAdepolarizing activity delayed dendritic development and reduced NPC proliferation resulting in decreased neuronal density.
Efeitos da infertilidade no relacionamento dos cônjuges
Authors: Faria Dieime Elaine Pereira de , Grieco Silvana Chedid , Barros Sônia Maria Oliveira de
Published: September 2012

Trata-se de um estudo sobre os efeitos da infertilidade no relacionamento dos cônjuges, com os objetivos de descrever o perfil da população de estudo e analisar os efeitos da infertilidade na vida emocional, sexual e conjugal. Para tal, foi realizado um estudo transversal e prospectivo em instituição especializada. A amostra foi constituída por 50 casais inférteis com seis anos de infertilidade em média. As mulheres manifestaram sentimentos negativos perante a infertilidade, enquanto os homens assumiram uma postura de suporte e apoio. Os efeitos na vida sexual foram mais expressivos nas mulheres, e o tratamento da infertilidade levou a mudanças positivas para ambos os cônjuges. Ao comparar os efeitos da infertilidade sobre os indivíduos que haviam realizado mais de um tratamento com aqueles no primeiro tratamento, observamos que não houve diferenças entre as mulheres; entre os homens houve diferenças no aspecto emocional (frustração e alívio) e no relacionamento conjugal (fortalecimento e amadurecimento).
Avaliação de um instrumento para classificação de pacientes pediátricos oncológicos
Authors: Andrade Sandra de , Serrano Sérgio Vicente , Nascimento Maria Salete de A. , Peres Stela Verzinhasse , Costa Allini Mafra da , Lima Regina Aparecida Garcia de
Published: September 2012

Este estudo teve como objetivos avaliar a reprodutibilidade interavaliadores do instrumento para a classificação de pacientes pediátricos portadores de câncer; verificar se o instrumento de classificação de pacientes é adequado a pacientes pediátricos portadores de câncer e elaborar uma proposta de modificação do instrumento, permitindo a adaptação para pacientes pediátricos oncológicos. Foram avaliados, na unidade de internação pediátrica de um Hospital de câncer, 34 pacientes pelas equipes de médicos, enfermeiros e técnicos de enfermagem. Para a avaliação do grau de concordância entre os escores obtidos pelos avaliadores foi utilizado o coeficiente Kappa, que revelou um valor intermediário/alto nas classificações objetivas, e um valor baixo nas subjetivas. Conclui-se que o instrumento é confiável e reprodutível, porém, para classificação do paciente pediátrico oncológico, sugere-se a complementação de itens para atingir um resultado mais compatível com a realidade dessa população.
Social support, socioeconomic and clinical risk: comparison between to neighborhoods in a Brazilian upcountry town
Authors: Ferreira Milce Burgos , Nunes Marilene Rivany , Reis Geraldo Cássio dos , Morraye Mônica de Andrade , Rocha Semiramis Melani de Melo
Published: September 2012

The objective of this study was to compare the perceptions of two families living in two different neighborhoods (rated according to risk levels) regarding social support. A questionnaire was designed to assess social support according to the following dimensions: instrumental, emotional, religious, and support from friends, neighbors and family. The sample was comprised as follows: considering the 114 families living in neighborhood 1, 52 families were interviewed; and among the 162 families living in neighborhood 2, 60 families were interviewed. No significant difference was found related to instrumental, religious and emotional support, including the support from relatives among the families from both neighborhoods. The results disagree with the reviewed literature, which indicated a strong association between social support and families living at socioeconomic risk. In conclusion, social support is important for families, regardless of their risk stratification.
Desempenho de índices de gravidade para estimar risco de morte em Unidades de Terapia Intensiva
Authors: Silva Lilian Carvalho da , Nogueira Lilia de Souza , Settervall Cristina Helena Costanti , Sousa Regina Marcia Cardoso de , Padilha Katia Grillo
Published: September 2012

O Simplified Acute Physiology Score II (SAPS II) e o Logistic Organ Dysfunction System (LODS) são instrumentos utilizados para classificar pacientes internados em Unidades de Terapia Intensiva (UTI) conforme a gravidade e o risco de morte, sendo um dos parâmetros da qualidade da assistência de enfermagem. Este estudo teve por objetivo avaliar e comparar as performances do SAPS II e do LODS para predizer mortalidade de pacientes admitidos em UTI. Participaram do estudo 600 pacientes de quatro diferentes UTIs de São Paulo, Brasil. A curva Receiver Operator Characteristic (ROC) foi utilizada para comparar o desempenho discriminatório dos índices. Os resultados foram: as áreas sob a curva do LODS (0.69) e do SAPS II (0.71) apresentaram moderada capacidade discriminatória para predizer mortalidade. Não foi encontrada diferença estatisticamente significativa entre as áreas (p=0,26). Concluiu-se que houve equivalência entre SAPS II e LODS para estimar risco de morte de pacientes em UTI.
Qualidade do sono em portadores do vírus da imunodeficiência humana
Authors: Ferreira Luciana Tiemi Kuranishi , Ceolim Maria Filomena
Published: September 2012

Este estudo teve por objetivo caracterizar a qualidade do sono de pessoas com o vírus da imunodeficiência humana (HIV) - AIDS - , com ou sem manifestações clínicas e sob tratamento ambulatorial. Para tal, foi realizada pesquisa descritiva e transversal. Os instrumentos utilizados foram: Questionário de Caracterização Sociodemográfica e Clínica; Índice de Qualidade de Sono de Pittsburgh (PSQI-BR). Participaram da pesquisa 122 pacientes (55,7% de homens e 44,3% de mulheres, com idade média de 42,3 (± 8,9 anos), dos quais 53,3% referiram apresentar sono de boa qualidade e 46,7%, sono de má qualidade. Dormiam, em média, 7,3 (± 1,8) horas, com latência de 23,2 (± 26,2) minutos e eficiência do sono de 87,8% (± 14,4). Observou-se associação significativa entre o sono de boa qualidade e os seguintes fatores: ter companheiro(a); apresentar carga viral indetectável; manter comportamento de risco. Recomenda-se que os profissionais de enfermagem incluam sistematicamente questões sobre o sono ao avaliarem o paciente com HIV/AIDS, detectando alterações precocemente e reunindo subsídios para o planejamento de intervenções.
Historia cultural de los cuidados paliativos en las sociedades primitivas: revisión integrativa
Authors: Siles González José , Solano Ruiz Maria del Carmen
Published: September 2012

Este estudio tiene el objetivo de describir la evolución de los cuidados paliativos, reflexionando sobre la posibilidad de su origen en las culturas primitivas y su relación con el inicio del culto a los muertos. Se describe el cambio producido en las estructuras, las interacciones simbólicas y sociales implicadas en el desempeño de cuidados paliativos durante la prehistoria: unidad funcional, marco funcional y elemento funcional. El marco teórico se fundamenta en la historia cultural, el modelo estructural dialéctico y el interaccionismo simbólico. Se aplicaron técnicas de categorización y análisis de la historia cultural y el estructuralismo dialéctico. Los cuidados paliativos ya existían en las sociedades primitivas vinculados, en gran medida, a los ritos de transición con un alto contenido simbólico. Las estructuras sociales: unidad funcional, marco funcional y elemento funcional; constituyen los pilares sobre los que se sustentaron los cuidados paliativos en las sociedades prehistóricas.
Conforto acústico na percepção de escolares alfabetizados
Authors: Santos Juliana Feitosa dos , Seligman Lilian , Tochetto Tania Maria
Published: September 2012

OBJETIVO: Verificar o conforto acústico de alunos alfabetizados. MÉTODOS: Participaram da pesquisa 82 crianças, de 8 a 10 anos, alunos do terceiro e do quarto ano do Ensino Fundamental, de quatro escolas municipais de Santa Maria. Dividiu-se a amostra em dois grupos - expostos e não expostos a níveis maiores que 80 dB(A). Para a seleção da amostra realizou-se inspeção visual do meato acústico externo, audiometria tonal e vocal e timpanometria. Para a pesquisa do conforto acústico foi aplicado um questionário baseado no modelo de escala somatória Likert, com a finalidade de avaliar as atitudes em relação ao conforto acústico. Foram executadas mensurações acústicas nas salas de aula, por meio de dosímetro. Os resultados foram analisados estatisticamente. RESULTADOS: O nível sonoro médio obtido por sala de aula variou de 51,9 dB(A) à 114 dB(A). Do total de 82 crianças, 20,7% estavam expostas a níveis mais elevados que 80 dB(A). O desconforto relatado pelas crianças apresentou um percentual de 46,3% dentre o grupo total. O maior percentual de desconforto (51,23%) foi verificado para a afirmativa que investiga se o barulho atrapalha a leitura e a escrita. Em relação à inteligibilidade de fala, prevaleceu a atitude de conforto. Quanto à dificuldade na leitura e escrita, foi verificado o maior percentual de desconforto indicado entre os respondentes. CONCLUSÃO: A sensação de desconforto predominou em ambos os grupos estudados.
Questionário sobre dificuldades comunicativas percebidas por pais de crianças do espectro do autismo
Authors: Balestro Juliana Izidro , Fernandes Fernanda Dreux Miranda
Published: September 2012

OBJETIVO: Elaborar um questionário para o levantamento de dificuldades comunicativas percebidas por pais e/ou cuidadores de crianças do espectro do autismo em relação a seus filhos. MÉTODOS: Os aspectos específicos abordados no questionário foram identificados a partir da literatura e da experiência clínica das autoras em dois serviços especializados. As questões foram organizadas segundo diferentes domínios e as respostas registradas numa escala tipo Likert. Foi realizado um estudo piloto com 40 pais, 20 pais de crianças do espectro do autismo e 20 pais de crianças sem queixas de linguagem, como forma de verificar a aplicabilidade do questionário construído e sua utilidade na identificação de dificuldades específicas da população alvo. Foi calculado o nível de concordância das questões e os resultados dos grupos foram comparados entre si (teste t Student). RESULTADOS: O questionário foi desenvolvido de maneira a abranger aspectos fundamentais para o relacionamento interpessoal, tanto no âmbito comunicativo quanto social. Foi dividido em 24 questões fechadas que abrangem quatro domínios; e uma questão aberta, com espaço para que os pais relatassem algo relevante e que não tenha sido perguntado. O estudo possibilitou testar a compreensão do instrumento e a análise estatística indicou que 19 questões apresentaram diferença. CONCLUSÃO: O questionário elaborado identificou diferenças na percepção e atitude de pais de crianças do espectro do autismo e de crianças sem queixa de linguagem, em relação às dificuldades de comunicação com seus filhos. Dessa forma, mostrou-se útil para o levantamento dessas dificuldades em um grupo maior de indivíduos.
Alterações dos processos fonológicos e índice de gravidade entre escolares com dislexia e escolares com bom desempenho acadêmico
Authors: Cardoso Monique Herrera , Romero Ana Carla Leite , Capellini Simone Aparecida
Published: September 2012

OBJETIVO: Comparar a ocorrência de processos fonológicos alterados e utilizar o índice de gravidade do transtorno fonológico para comparar uma amostra de fala e de escrita de escolares disléxicos e de alunos com bom desempenho acadêmico. MÉTODOS: Participaram 34 escolares, distribuídos entre o segundo e o quinto ano escolar, de ambos os gêneros, na faixa etária de 8 anos a 11 anos e 11 meses de idade, divididos em: G1 (17 escolares com diagnóstico interdisciplinar de dislexia) e G2 (17 escolares com bom desempenho acadêmico). Foram aplicadas tarefas de Imitação e de Nomeação (ABFW), compostas, respectivamente, por 39 vocábulos e 34 figuras. Foi solicitada também, a elaboração de uma redação temática, a partir de uma sequência lógica de figuras. RESULTADOS: Os escolares disléxicos deste estudo apresentaram desempenho inferior, quando comparados aos escolares com bom desempenho acadêmico, em relação à fala, no processo fonológico de simplificação de encontro consonantal (prova de imitação) e em relação à análise de produção da escrita nos critérios: traçado da letra cursiva sem alteração, disgrafia funcional, hiposegmentação, e ortografia correta. Entretanto, a gravidade do transtorno fonológico da amostra da fala e da escrita, foi leve em ambos os grupos. CONCLUSÃO: Os escolares com dislexia apresentaram alterações nos processos fonológicos e na escrita, com rendimento inferior aos escolares com bom desempenho acadêmico. Quanto ao índice de gravidade PCC-R das amostras da fala e da escrita, tanto os disléxicos como os escolares com bom desempenho acadêmico, apresentaram classificação de grau leve.
Parâmetros acústicos do contraste de sonoridade das plosivas no desenvolvimento fonológico típico e no desviante
Authors: Melo Roberta Michelon , Mota Helena Bolli , Mezzomo Carolina Lisbôa , Brasil Brunah de Castro , Lovatto Liane , Arzeno Leonardo
Published: September 2012

OBJETIVO: Investigar se as crianças com desvio fonológico apresentam características acústicas distintas de sons plosivos surdos e sonoros das crianças com desenvolvimento fonológico típico. MÉTODOS:Participaram do estudo 11 crianças com desenvolvimento fonológico típico e cinco com desvio fonológico e dificuldade na aquisição do traço [+voz] das consoantes plosivas. Por meio de palavras (['papa], ['baba], ['tata], ['dada], ['kaka] e ['gaga]) inseridas em frases-veículo, mediu-se o voice onset time, a duração da vogal, a amplitude do burst e a duração da oclusão de cada plosivo. Foram comparados todos os registros acústicos de plosivos surdos e sonoros intra e intergrupo, por meio de testes estatísticos. RESULTADOS: As crianças com desenvolvimento fonológico típico apresentaram resultados significativos, principalmente, na diferenciação dos parâmetros de voice onset time, duração da vogal e oclusão de plosivos surdos e sonoros, diferentemente do observado para as crianças com desvio fonológico. A comparação entre os dois grupos mostrou diferenças quanto à produção de voice onset time e duração da oclusão dos plosivos sonoros. Com relação aos demais parâmetros analisados, os valores foram aproximados entre os grupos, sem diferença estatística. CONCLUSÃO: A marcação do contraste de sonoridade do grupo desviante mostra-se distinta em relação ao grupo de crianças com desenvolvimento fonológico típico, principalmente no que se refere ao voice onset time e à duração da oclusão dos segmentos sonoros.
Cyberspace design: a new challenge for planners
Authors: Apostol Ileana , Antoniadis Panayotis , Banerjee Tridib
Published: September 2012

This paper proposes a conceptual framework for planning and design practice to incorporate self-consciously the hybrid space of the virtual and physical. Cyberspace has now become a commonplace environment for social and public life, and its complex uses are entwined with those of the existential life in the physical environment. Therefore, it is argued, planners must engage in the design of the parallel realities of social and public life in these spaces. This paper proposes to look at them in a rhizome-like spatial formation, and in their future design to apply related planning knowledge on places and communities. Based on observations of online activity, the paper illustrates a method to analyse cyberspace's quality by means of Kevin Lynch's taxonomy of images, and of William H. Whyte's method to evaluate spatial uses. Spatial elements are identified through analogies between the virtual and the physical social environments, in order to derive alternatives for future (hybrid) spatial design.
District centre regeneration – a European perspective
Authors: Brombach Karoline , Simon-Philipp Christina , Kurth Detlef
Published: September 2012

The regeneration of district centres is an issue of practical relevance for European cities that want to improve liveability and encourage urban living. Yet, this subject is often eclipsed by the more prominent aspects of inner city renewal and is relatively undocumented in the literature. This paper seeks to give an overview on the subject of district centres and strategies against their decline, based on experiences from the Interreg Project ‘Managing district centres in North West Europe’ (Mandie). In the first part, centre types and morphological categories are proposed that help to identify local weaknesses and strengths. In the second part, approaches to district centre management are distinguished and the question is raised of how professionals may qualify for this task. Finally, three principles for successful district centre regeneration are illustrated. It becomes clear that district centre regeneration is a multi-faceted endeavour which remains indispensible for the much desired urban renaissance of cities.
Mixtures of genetically modified wheat lines outperform monocultures
Authors: Zeller Simon L. , Kalinina Olena , Flynn Dan F. B. , Schmid Bernhard
Published: September 2012

Biodiversity research shows that diverse plant communities are more stable and productive than monocultures. Similarly, populations in which genotypes with different pathogen resistance are mixed may have lower pathogen levels and thus higher productivity than genetically uniform populations. We used genetically modified (GM) wheat as a model system to test this prediction, because it allowed us to use genotypes that differed only in the trait pathogen resistance but were otherwise identical. We grew three such genotypes or lines in monocultures or two‐line mixtures. Phenotypic measurements were taken at the level of individual plants and of entire plots (population level). We found that resistance to mildew increased with both GM richness (0, 1, or 2 Pm3 transgenes with different resistance specificities per plot) and GM concentration (0%, 50%, or 100% of all plants in a plot with a Pm3 transgene). Plots with two transgenes had 34.6% less mildew infection and as a consequence 7.3% higher seed yield than plots with one transgene. We conclude that combining genetic modification with mixed cropping techniques could be a promising approach to increase sustainability and productivity in agricultural systems, as the fitness cost of stacking transgenes within individuals may thus be avoided.
Biological surrogacy in tropical seabed assemblages fails
Authors: Sutcliffe P. R. , Pitcher C. R. , Caley M. J. , Possingham H. P.
Published: September 2012

Surrogate taxa are used widely to represent attributes of other taxa for which data are sparse or absent. Because surveying and monitoring marine biodiversity is resource intensive, our understanding and management of marine systems will need to rely on the availability of effective surrogates. The ability of any marine taxon to adequately represent another, however, is largely unknown because there are rarely sufficient data for multiple taxa in the same region(s). Here, we defined a taxonomic group to be a surrogate for another taxonomic group if they possessed similar assemblage patterns. We investigated effects on surrogate performance of (1) grouping species by taxon at various levels of resolution, (2) selective removal of rare species from analysis, and (3) the number of clusters used to define assemblages, using samples for 11 phyla distributed across 1189 sites sampled from the seabed of Australia's Great Barrier Reef. This spatially and taxonomically comprehensive data set provided an opportunity for extensive testing of surrogate performance in a tropical marine system using these three approaches for the first time, as resource and data constraints were previously limiting. We measured surrogate performance as to how similarly sampling sites were divided into assemblages between taxa. For each taxonomic group independently, we grouped sites into assemblages using Hellinger distances and medoid clustering. We then used a similarity index to quantify the concordance of assemblages between all pairs of taxonomic groups. Surrogates performed better when taxa were grouped at a phylum level, compared to taxa grouped at a finer taxonomic resolution, and were unaffected by the exclusion of spatially rare species. Mean surrogate performance increased as the number of clusters decreased. Moreover, no taxonomic group was a particularly good surrogate for any other, suggesting that the use of any one (or few) group(s) for mapping seabed biodiversity patterns is imprudent; sampling several taxonomic groups appears to be essential for understanding tropical/subtropical seabed communities. Consequently, where resource constraints do not allow complete surveying of biodiversity, it may be preferable to exclude rare species to allow investment in a broader range of taxonomic groups.
Survival analysis of a critical resource for cavity‐nesting communities: patterns of tree cavity longevity
Authors: Edworthy Amanda B. , Wiebe Karen L. , Martin Kathy
Published: September 2012

Tree cavities are a vital multi‐annual resource used by cavity‐nesting birds and mammals for nesting and shelter. The abundance of this resource will be influenced by the rates at which cavities are created and destroyed. We applied the demographic concepts of survival and longevity to populations of tree holes to investigate rates of loss for cavities in three tree species, as well as how characteristics of nest trees, habitat type, and species of excavator affected the persistence of tree cavities in trembling aspen,Populus tremuloides(95% of cavities were in aspen trees), in interior British Columbia, Canada. By modeling survival of 1635 nesting cavities in aspen over a time span of 16 years, we found that the decay stage of the nest tree was the most important factor determining cavity longevity. Cavities in trees with advanced decay had a relatively short median longevity of 7 years (95% CI 6–9 years), whereas those in living trees had a median longevity of more than 15 years. We found that cavity longevity was greater in continuous forest than in aspen grove habitat. Interestingly, cavities formed by weak excavators survived as long as those created by Northern Flickers (Colaptes auratus), despite occurring in more decayed tree stems. Thus, weak excavators may be selecting for characteristics that make a tree persistent, such as a broken top. Our results indicate that retention of cavities in large, live aspen trees is necessary to conserve persistent cavities, and that cavity longevity will have a large effect on the structure and function of cavity‐using vertebrate communities.
Costs, benefits, and fitness consequences of different migratory strategies
Authors: Alves José A. , Gunnarsson Tómas G. , Hayhow Daniel B. , Appleton Graham F. , Potts Peter M. , Sutherland William J. , Gill Jennifer A.
Published: September 2012

The relative fitness of individuals across a population can shape distributions and drive population growth rates. Migratory species often winter over large geographic ranges, and individuals in different locations experience very different environmental conditions, including different migration costs, which can potentially create fitness inequalities. Here we used energetics models to quantify the trade‐offs experienced by a migratory shorebird species at locations throughout the nonbreeding range, and the associated consequences for migratory performance, survival, and breeding habitat quality. Individuals experiencing more favorable winter conditions had higher survival rates, arrived on the breeding grounds earlier, and occupied better quality breeding areas, even when migration costs are substantially higher, than individuals from locations where the energy balance on the wintering grounds was less favorable. The energy costs and benefits of occupying different winter locations can therefore create fitness inequalities which can shape the distribution and population‐wide demography of migratory species.
Dog-Helen and Homeric Insult
Authors: Graver Margaret
Published: September 2012

Helen's self-disparagement is an anomaly in epic diction, and this is especially true of those instances where she refers to herself as "dog" and "dog-face." This essay attempts to show that Helen's dog-language, in that it remains in conflict with other features of her characterization, has some generic significance for epic, helping to establish the superiority of epic performance over competing performance types which treated her differently. The metaphoric use of χύων and its derivatives has not been well understood: the scholiast's gloss "shameless" is no more than a functional equivalent, and interpretations linking it primarily with reckless courage or with sexual misconduct are not well founded. An analysis of contexts suggests that "dog" as an insult has a fundamental association with physical greed and even cannibalism. The implied notion of avarice, however, may also be extended into other behavioral spheres, including those of fighting and sexuality. A character may also be called "dog" for reviling or slandering another unjustly. These strongly negative implications are out of keeping with the character given to Helen in epic. For where tragedy and lyric generally represent Helen as blameworthy, Homeric epic tends to absolve her of blame and to make her personally as well as physically attractive. The unexpected application of dog-terms to her may therefore be read as an allusion to other versions of the Troy legend which were more hostile to Helen. Negative portrayals of Helen are likely to have figured in the ancient kitharodic narrative which was a precursor of both tragedy and lyric; these are perhaps the unfriendly "songs" mentioned by Helen at Il. 6.357. By referring to such defamatory narratives through the dog-insult and through other instances of Helen's self-blame, the epic performer marks his own more favorable treatment as a generic preference.
The "Kypria" and Its Early Reception
Authors: Scaife Ross
Published: September 2012

This article analyses the remains of the seventh-century epic known as the "Kypria" from literary as well as iconographical perspectives. The literary study of the "Kypria" includes a provisional reconstruction followed by a defense of the poem against many critics, beginning with Aristotle, who have found it tediously linear and unsophisticated. The "Kypria" apparently made artful use of catalogues, flashbacks, digressions, and predictions as traditional sources of epic poikilia. The second part of this study examines several (but not all) instances in which the "Kypria" influenced representational art of Archaic Greece. Study of the iconographical tradition often yields details which may be retrojected into the poem, albeit with varying degrees of certitude. The influence of the "Kypria" on the iconography of Greek art, especially pronounced considering the greater overall prestige of the Iliad and the Odyssey, is explained on the basis of the themes and purposes of the cyclic poem. First, the "Kypria" was so often translated into the visual medium because of the high number of potentially interesting subjects which it offered to artists. Second, Proklos commented that the poems of the epic cycle were later preserved less for their literary quality than for the concatenation of epic events which they preserved. In choosing to transfer this poetic tradition to their own media, archaic artists simultaneously evoked the powerful causality of the poem and, more importantly, alluded to the larger story of the Trojan War.
The Tomb of Aias and the Prospect of Hero Cult in Sophokles
Authors: Henrichs Albert
Published: September 2012

Sophocles' Oedipus at Colonus has traditionally been regarded as the poet's primary tragedy involving hero cult; this essay explores the more subtle but no less ritually explicit hero cult of the Aias first outlined by Burian. The passage, as Burian saw, occurs when the young Eurysakes kneels at his father's body and Teukros conducts an unusual combination of rites: supplication, curse, offering of hair, and magic (1168-84). One crucial direction to the child, kai phulasse (1180), however, is here not understood to be a paradox of the suppliant who "protects" what he seizes but rather his physical attachment to the locus where he abides as well as his ritual dependence on the source of protection (as with Orestes in Eum. 242f., 439f.). By saying a curse and obtaining protection, Teukros and Eurysakes indicate how the still-warm body of the dead hero has already acquired special powers after death: specifically, the power to bestow both blessings and curses on mortals. The argument turns from the body to the tomb, the physical and lasting monument of hero cult, which the Sophoclean audience would know. The preceding scene ends with a pivotal choral passage where the hero's burial and cult are prescribed in highly Homeric terms (1163-67). This passage forms an important link between the opposing views of the fate of the corpse (Menelaos vs. Teukros) and also between the hero's death and burial. This choral celebration of the hero's future status is cast in traditional Homeric language, but with some revealing inversions. One is the reversal of the verb whereby the earth "holds" (katechei) or possesses heroes in Homer, while Aias occupies and possesses his tomb (1167, kathexei). The evolution of Homeric views of death is traced (Archilochos, Simonides). In Sophocles' Aias the chorus performs the burial as a ritual act establishing a cult, long before it happens at the end of the play. The article concludes with a discussion of the historical cults of Aias known to the Athenians and of the more significant way that Aias (a suicide) becomes a hero: not self-consciously, as Oedipus did, but through rituals performed by his family and community. In the Aias, the poet's sense of hero cult lies closer to Homer and the epic tradition than it does, for instance, to Aeschylus.
Pivotal Contrafactuals in Homeric Epic
Authors: Louden Bruce
Published: September 2012

Some sixty times in the Iliad and Odyssey, the narrator describes a sequence of events with the climactic phrase, "And now X would have happened, had not Y intervened." Though some recent studies have begun to focus on this narrative technique, a fuller accounting of its properties remains desirable, as many of the passages where it is employed are quite significant to the overall construction of the plots. I have termed the phenomenon pivotal contrafactuals. The present study argues that the composer achieves three general narrative benefits by employing this device. First, it is a method for emphatically changing the direction of the plot (hence the adjective "pivotal"). Second, it allows the narrator to confer added emphases of various kinds upon the events he describes. Third, the narrator often uses the construction to make an editorial comment upon the character on whose behalf the intervention occurs. Intriguingly, Homer appears to link some pivotal contrafactuals together through various means. Some occur as equivalent elements in different multiforms of a common type scene. Some occur in different narratives describing the same event. These latter raise the possibility that divine intervention of which he is unaware occurs in Odysseus's narrative of his wanderings. Finally, I suggest that a passage at the beginning of the Catalogue of Ships, which has attracted various interpretations, is a modified pivotal contrafactual.
The Mythological Paintings in the Macellum at Pompeii
Authors: Barringer Judith M.
Published: September 2012

This article attempts to establish and examine the context of the two remaining mythological paintings in the Macellum, the central market of Pompeii. Panels of Io and Argos and of Penelope and Odysseus grace the interior walls, and while the identification of the Penelope figure has been the subject of debate, she clearly derives from Greek prototypes of Penelope, both material and theatrical. Indeed, scholars suggest that the Io panel and perhaps the Penelope painting as well are copies of Greek panel paintings created by a fourth-century B.C. artist, but it is argued here that their pairing seems to be a Roman creation and that they were part of a larger narrative program. The paintings are compositional opposites and share the narrative technique of depicting moments of quiet tension; this choice of narrative moment is one that began in the Greek world; particularly during the Hellenistic period, and was developed and enhanced by the Romans. Moreover, this interest in creating tension for the spectator, and in the relationship between viewer and image, is also demonstrated by the inclusion of a spectator figure in the Penelope painting. Although the other paintings do not survive, their subjects are known from a nineteenth-century drawing and from nineteenth-century descriptions, and these too share the same narrative technique. If the lost paintings are (also) copies of Greek originals, then the Macellum may have served as a picture gallery for Pompeii's inhabitants. A careful reading of the Macellum paintings (both extant and lost) of Greek myths, their juxtaposition and relationship to each other, and their reception in Roman literature and society reveals that the paintings were arranged as a program, a moralizing ensemble, designed to instruct the viewer on the proper behavior of Roman matrons.
Achilles' Heel: The Death of Achilles in Ancient Myth
Authors: Burgess Jonathan
Published: September 2012

This study examines the death of Achilles in ancient myth, focusing on the hero's imperfect invulnerability. It is concluded that this concept is of late origin, perhaps of the Hellenistic period. Early evidence about Achilles' infancy does not suggest that he was made invulnerable, and early evidence concerning his death apparently indicates that Achilles was wounded more than once. The story of Achilles' heel as we know it is therefore late, though it is demonstrable that certain themes and motifs of earlier traditions about Achilles were preserved in later traditions. What caused the concept of Achilles' imperfect invulnerability to emerge, it is proposed, was the late story in which the hero is ambushed in the temple of Thymbraean Apollo. Certainly Achilles was wounded in the lower leg in early Greek myth. An explanation is needed if this does not reflect the story of his imperfect invulnerability, and the arguments of several scholars are surveyed. The theory that the "swift-footed" hero was first immobilized by a lower wound before being slain is ultimately favored, though it is suggested that invulnerable armor and poison may have played a role. A comparative approach to myth and ritual is employed, with attention given to evidence from various areas (e.g., Scythia, the Near East) and ages (Proto-Indo-European to modern) in an effort to illuminate stories about the infancy and death of Achilles. The study also assesses two alleged reflections in the Iliad of Achilles' death, the death of Patroclus in Book 16 and the wounding of Diomedes in Book 11. The evidence in ancient art and literature about the death of Achilles is often obscure, but this exploration of continuity and innovation in myth about Achilles should assist our understanding of it.
Taking the "Nestor's Cup Inscription" Seriously: Erotic Magic and Conditional Curses in the Earliest Inscribed Hexameters
Authors: Faraone Christopher A.
Published: September 2012

This essay argues that the Nestor's Cup Inscription is not a joke, but rather a magical spell designed to work as an aphrodisiac. It is divided into two parts, the first dealing with the hexametrical couplet (lines 2 and 3 of the inscription) and the second with the opening line. In the first section the author argues that the hexameters comprise a bonafide magical incantation, pointing out that: (1) the two hexameters take the semantic form of a conditional curse well known from oaths and proprietary inscriptions of the archaic period and from the earliest extant magical texts; (2) hexametrical verse was commonly used as early as the classical period-and probably much earlier-in magical incantations; (3) prosaic words in the inscription (such as potêrion) that do not appear elsewhere in literary hexameters, but are used in the Greek magical tradition, may in fact be terms of a quasi-technical nature that survive from a very old, but poorly documented, tradition of metrical incantations; and (4) the deictic pronoun in the second line of the inscription (το̃δε) signals the use of performative language common in magical spells. The second section of the paper turns to the opening line of the inscription, arguing that instead of introducing some sophisticated intertextual joke, this line can be best understood as a label or rubric of the sort frequently used to signify authorship or ownership in archaic inscriptions and other early texts to "seal" a writer's name to his œuvre. In later magical texts such rubrics boast a legendary author of a particular incantation or ritual. The author concludes that this inscription records an erotic spell traditionally spoken over a cup without any recourse to writing, and that its appearance on the cup from Pithecusae resulted from a random and ultimately unsuccessful experiment to transfer and transform an oral incantation into a written one in an age of incipient literacy.
Image, Text, and Story in the Recovery of Helen
Authors: Hedreen Guy
Published: September 2012

Ancient Greek visual representations of the recovery of Helen by Menelaos are generally thought to depend closely on two distinct poetic sources. This paper argues that this belief is untenable. The principal theoretical assumption underlying it, that there will always be a close fit between ancient Greek poetic and artistic representations of a given story, is not the only conceivable relationship between poetry and art in Archaic and Early Classical Greece. The empirical evidence advanced to support the belief, the occurrence of similar motifs in both the poetic sources and the visual representations, is strained: scholars have read into the pictures motifs or intentions, including nudity and seduction, that are known from literature but have not been given unambiguous visual form in the pictures. This paper argues that the relationship between the artistic and literary representations of the recovery of Helen is much more distant and less direct than most scholars have thought. The same general story underlies all the pictorial representations of the subject in the Archaic and Early Classical periods, but no specific poetic source was necessarily behind the story circulating among the artists. This study draws attention, in particular, to methods of storytelling that are unique to the visual arts. It addresses in detail one of the most striking and problematic aspects of the iconography of the recovery of Helen, the variety of physical settings of the event, and argues that the pictorial elements of setting provide important narrative information that verbal narratives would convey in a different way.