bluuebunny/crossref_metadata_2025 huggingface dataset:
“Trishkin caftan” of the planned economy
Authors: Экштут С.А.
Published: July 2023

До недавнего времени в хронике истории Советского Союза 1969 год терялся на фоне ярких событий предшествующих и последующих лет. Недавно рассекреченные и опубликованные в книге «Секретариат ЦК КПСС. Рабочие записи и протоколы заседаний. 1969 г.» архивные документы и материалы позволяют понять ключевую роль этого года в истории СССР: именно с этого года в стране наступил застой в идеологии и экономике. Отныне жизнь всех без исключения представителей творческой интеллигенции СССР четко делится на периоды до и после 7 января 1969 г. Под недавно закончившейся оттепелью подводится большая и жирная черта.

Until recently, in the chronicle of the history of the Soviet Union, 1969 was lost against the backdrop of the bright events of previous and subsequent years. Recently declassified and published in the book “Secretariat of the Central Committee of the CPSU. Working notes and minutes of meetings. 1969" archival documents and materials make it possible to understand the key role of this year in the history of the USSR: it was from this year that stagnation in ideology and the economy began in the country. From now on, the life of all representatives of the creative intelligentsia of the Soviet Union without exception is clearly divided into periods before and after January 7, 1969. Under the recently ended thaw, a large and bold line is being drawn.
Conservative Management of Unicystic Ameloblastoma- A Case Report
Authors: Agarwal Shivam
Published: July 2023

Ameloblastoma is the most common benign odontogenic tumor of the jaws that constitutes about 1% of all cysts and tumors of the jaws1,2. It is generally a painless, slow growing, locally aggressive tumor causing expansion of the cortical bone, perforation of the lingual or the buccal cortical plate and infiltration to the soft tissues. It has peak incidence in third and fourth decade of life but can be found in any age group with equal gender predilection (1:1)1,5. The relative frequency of mandible to maxilla is reported to be varying from 80% -20% to 99–1%. In the mandible majority of Ameloblastoma are found in the molar ramus region1,3. In a conventional radiograph, Ameloblastoma can present as either unilocular or multilocular corticated radiolucency. The bony septae results in a honey comb, soap bubble or tennis racket appearance. In some places, cortical plates are spared and expanded where as in other region they are destroyed; root resorption is a common finding6. Buccal and lingual cortical plate expansion is more common in Ameloblastoma than in other tumour7. Conventional radiograph is sufficient for small mandibular lesions but maxillary lesions and extensive lesions require CBCT, CT and MRI to establish the extent of the lesion7. The challenge in managing Ameloblastoma is by attaining complete excision and reconstruction of the defect when the tumor is large. Ameloblastoma is treated by enucleation, curettage or surgical excision depending on size and type of the lesion and conservative therapy also.

This report gives a comprehensive knowledge regarding the conservative therapy using a  Iodoform and paraffin paste which has been a boon in treatment of odontogenic tumor.
Coming of Age of The Third Dentition : Multi-unit Immediate Loading Protocol.
Authors: Sarah  , Gupta Juhi , Lele Priya , Shah Yashodharaa
Published: July 2023

Abstract: Evolution in implant dentistry has been unprecedented. Several protocols have been proposed in field of implant rehabilitation. Concepts have been redefined considering heightened patient anticipation of alleviation of discomfort, better esthetics, shorter lag time period of treatment. Immediate loading is one such area of interest increasingly done as a substitute for conventional loading. Immediate loading has considerably lessened the lag period between surgical phase and restorative phase. Here presenting a case report of a partially edentulous 33 year old male who underwent implant surgical procedure conforming to immediate loading protocol.
Oral Manifestations of Covid-19: A Critical Review
Authors: Neha Bansal  , Gaurav goyal  , Vandana Chhabra  , Poonam Sood
Published: July 2023

The COVID-19 (SARS-CoV-2) pandemic has proven to be an immense public health concern affecting various parts of the human biologic systems. The baffling disparities pertaining to the symptoms experienced by each afflicted individual present a difficult challenge to the medical community. The oral cavity is certainly not an exception.  The oral effects noted could be either direct effects of the virus itself or the result of an indirect effect of the virus. Although the virus is still of utmost concern around the world, the study of its effects on the human body, including the oral cavity, unquestionably remains a work in progress. COVID-19 has caused a pandemic and it still going quite strong. This disease has many general or constitutional manifestations, among which oral manifestations can also be present. These manifestations are often non-specific and can occur in any viral infections as well. Hence, they have to be recognized distinctly by the dentist as well as Laboratory personnel. So here we have tried to collect available data regarding this, in the form of a review
A Comparative Evaluation of Wear of Enamel to Various Restorative Materials of Different Surface Finishes-An In Vitro Study
Authors: Khan Furkan Ahmed , Vyas Anup Kumar
Published: July 2023

Aim:The aim of this study is to evaluate the effect of different surface finish of various restorative materials on the wear of opposing enamel.Objectives of the study:1.To compare the amount of enamel loss in experimental groups of various restorative materials at different intervals of masticatory cycles. 2.To compare and evaluate the most compatible finished or polished surface of the restorative material causing least enamel wear. Materials and Methods: A total of 90 samples were prepared for this study - 75 in disc form and 15 enamel antagonist and divided into 6 groups. Group 1 - Enamel vs Enamel antagonist, Group 2 - Enamel vs Fiber Reinforced Composite disc, Group 3 Enamel vs  Autoglazed metal ceramic disc , Group 4 - Enamel vs  Overglazed metal ceramic disc, Group 5 - Enamel vs Polished  metal ceramic  disc by polishing kit, and Group 6 - Enamel vs PEEK disc were fabricated. 105 extracted premolars were collected and randomly divided into six groups of 15 each and 15 for enamel antagonist. Each tooth sample was weighed before wear testing using electronic analytical balance of 0.0001 g accuracy. Occlusal surfaces of these teeth were then abraded against the substrates in a wear machine for a total of 10,000 cycles. Each tooth sample was weighed after 5000 cycles and after the total of 10,000 cycles, respectively, using the same balance. Differences in weight of tooth samples before and after wear testing were evaluated statistically using One-way analysis of variance and Tukey’s post hoc tests was used. Results:  The values obtained for overall mean percentage weight loss after 10000 rotations in increasing order is observed: Group 1 (Enamel Vs Enamel 0.0043 ± 0.00) < Group 6 (Enamel Vs PEEK disc 00.0131 ± 0.01) < Group 2 (Enamel Vs Fiber reinforced composite 0.0258 ± 0.01) < Group 5 (Enamel Vs Polished metal ceramic disc 0.0294 ± 0.00) < Group 3 (Enamel Vs Autoglazed metal ceramic disc 0.0318 ± 0.01) < Group 4 (Enamel Vs Overglazed ceramic disc 0.0451 ± 0.01). Conclusion:PEEK showed the least amount of enamel wear followed by Fiber reinforced composite. Fiber reinforced composite may cause less wear than dental ceramics. Enamel wear produced by polished metal ceramic disc  is substantially less than autoglazed and over glazed metal ceramic disc. This study indicates that any potential damage to ceramic can directly affect enamel and suggests that porcelain should be polished instead of over glazed.

Key Words: Fiber reinforced composite, Autoglazed, Overglazed, Polished  surface, Wear, PEEK.
Transpalatal Arch and its Modifications
Authors: Pallavi Pallavi Vishavkarma , Isha Aggarwal  , Mittal Sanjay , Papkit Tanzin , Merry
Published: July 2023

Versatility has become key feature for an appliance to be chosen for any orthodontic treatment, one such appliance is transpalatal arch (TPA) which has numerous advantages while using in fixed orthodontic treatment. TPA not only provides additional anchorage but also used for active movement of individual teeth. The aim of this article is to present a broad review of the literature by including various modifications of TPA and their indications, to better assist the clinician for using it in different case
Awareness of Health care workers regarding Mucormycosis /Black fungus associated with global COVID - 19 pandemic in Rajasthan population – A Cross – sectional survey
Authors: Rimjhim  Jain  , Ashwini B Prasad  , Deepak Raisingani  , Harshit Srivastava  , Prachi Mital  , Ridhima Gupta
Published: July 2023

IntroductionTogether with the ongoing serious Covid-19 second wave in India, a serious fungal infection,mucormycosis has been increasingly found in Covid-19 recovered patients. Current trendsindicate that the surge is higher in patient with co-morbidities. Health care facilities need tostrengthen their infection prevention and control (IPC) programmes to prevent healthcare-associated outbreaks.Therefore, we conducted a cross-sectional survey of health-care workers in Rajasthan toassess their awareness of Mucormycosis as a result of the global COVID-19 pandemic, aswell as to learn about the possible link between invasive fungal sinusitis (mucormycosis) andcoronavirus disease, as well as how to prevent and manage it.MethodologyA web based cross–sectional study was conducted using convenience sampling. A self-administered anonymous questionnaire was designed in English and sent to the studyparticipants via link of Google form through social media platforms and email. Total of 378HCPs responded to survey.ResultsOut of 378 HCPs, majority of them were female (68.8%) with age <30 years (73.3%) and ofthese respondents most were dentists (82.2%).In assessing awareness of mucormycosis, 66.7%of HCPs believed the cause of the highprevalence of mucormycosis during COVID-19 was due to the higher prevalence of diabetes,indiscriminate use of steroids, immunocompromised patients with co-morbidities, usage ofunhygienic humidifiers & o2 lines and tubes. 57.9% of HCPs surveyed agreed that carefuland supervised use of systemic steroids should be consistent with current practice and 62.2%of HCPs agree that we need dynamic surveillance and control of diabetes mellitus or pre-diabetes in our population.

ConclusionFirst case of Covid-19-related Mucormycosis has now been found in Chile. Thus, it isimportant to recognise this infection at an early stage, so as to potentially reduce soft andhard tissue necrosis and severe complications and alert colleagues of this life-threateninginfection.
A Comparative Clinical Evaluation of Surgical Blade Abrasion and Partial Thickness Flap as Treatment Modalities for Gingival Pigmentation.
Authors: Mundra Rohit , Porwal Surbhi
Published: July 2023

Gingival hyperpigmentation is a major esthetic concern for many people, although it is not a medical problem, many people complain of dark gums as unesthetic. Gingival depigmentation is a periodontal plastic surgical procedure that removes or reduces hyperpigmented gingiva. Various methods like scalpel, free gingival autografts, electrosurgery, cryosurgery, and abrasion with diamond bur gingival hyperpigmentation is a major esthetic concern for many people, although it is not a medical problem, many people complain of dark gums as unesthetic. Gingival depigmentation is a periodontal plastic surgical procedure that removes or reduces hyperpigmented gingiva. Various methods like scalpels, free gingival autografts, electrosurgery, cryosurgery, abrasion with diamond bur, and various types of lasers have been used for cosmetic therapy of gingival melanin pigmentation. This article compare the efficacy of gingival melanin depigmentation done by excision with a surgical blade using scarping and partial thickness flap technique. and various types of lasers have been used for cosmetic therapy of gingival melanin pigmentation. This article compares the efficacy of gingival melanin depigmentation done by excision with a surgical blade using scarping and partial thickness flap technique.
Atypical Findings in the Management of Idiopathic Gingival Enlargement
Authors: Pati Ritam Chandra , Madan Ellora , Dutta Subharthi , Farheen
Published: July 2023

Idiopathic gingival enlargement is a rare non-hemorrhagic, slowly proliferative fibrous lesion of the gingival tissue in which no causative agent can be identified. These type of enlargement causes esthetic and functional problems. This case report highlights the diagnosis and treatment of the idiopathic gingival enlargement of a 14 years old female patient who presented with a generalized diffuse type of gingival enlargement in both the maxillary and mandibular arches which covers maximum portion of the crowns. Based on family history and clinical examination, diagnosis was made following which segment wise gingivectomy was carried out. Histopathologic evaluation was also done. Post operative enlargement was noticed on first week which gradually decreased to some extent in the third week post operatively.
Management of Lingual Traumatic Fibroma in An Epileptic Patient Using Diode Laser
Authors: Farheen  , Ellora Madan  , Ritam C Pati  , Vishal Kumar
Published: July 2023

Traumatic fibroma is a benign exophytic and reactive oral lesion that develops secondary to repetitive trauma or irritation. Most commonly affected sites are tongue, buccal mucosa, and lower labial mucosa. These are well demarcated, smooth, pedunculated or sessile, exophytic lesions which are similar to the surrounding mucosa in color. Generally, it is non-tender but local irritation may lead to painful ulceration. Treatment plan includes complete excision and removal of the cause of irritation. Excision can be done by scalpel, electrocautery or Laser.  The excision of the fibroma with diode laser is a safe procedure, with minimum postoperative discomfort and complications. Recurrences are rare but may occur due to repetitive trauma at the same site.
One Step Apexification in a Resorbed Tooth Using Autologous PRF as Internal Matrix and Biodentine Apical Plug
Authors: Agrawal Priyanka
Published: July 2023

Apexification is defined as a method to induce a calcific barrier in a root with open apex or the continued apical development of an incompletely formed root in teeth with necrotic pulp tissue. The presented case was of a 26‑year‑old male patient with discoloured tooth associated with external resorption and periapical pathology in relation to the upper front right tooth. Teeth with open apex due to root end resorption pose difficulties during endodontic treatment because of the wide‑open root apex and thin dentin walls. This article describes the procedure of single‑visit apexification using a new calcium silicate‑based material (Biodentine) as an apical barrier along with platelet‑rich fibrin as internal matrix.
Full Mouth Rehabilitation of A Child with Early Childhood Caries: A Case Report
Authors: Saharia Nancy Priya , Mathur Shivani , Verma Urvashi , - Priyanka
Published: July 2023

Early childhood caries is a multifactorial disease that severely degrades the primary maxillary incisors and molars in a child aged 71 months or younger. It can cause reduced masticatory efficiency, loss of vertical dimension, development of speech problems, esthetic-functional problems such as malocclusion and space loss, and psychological problems that can compromise the behavioral development of the child. The treatment of severely decayed primary teeth presents a special challenge to pediatric dentists. The present case report describes the oral rehabilitation of a 5-year-old male patient with type II ECC whose teeth were restored using various treatment modalities including preformed space maintainers, preformed zirconia crowns, fiber post, SSC, pulpectomies and composite restorations.

Keywords: Early Childhood Caries, Stainless-steel crowns, Zirconia crowns, Fibre-post, Dental caries
Encontros com mulheres em situação de vulnerabilidade social: relato de experiência em extensão
Authors: DORNELES Stella Gontijo Sant'Anna Vaz de Melo , PIRES Bruna Antunes de Miranda , TEIXEIRA Eduarda de Oliveira , TAKESHITA Isabela Mie , AZEVEDO Monica das Graças de
Published: July 2023

O presente artigo visa apresentar os resultados do projeto de extensão nomeado “Ser Mulher” desenvolvido em Faculdade Privada de Medicina. As atividades foram desenvolvidas no segundo semestre de 2022, com três encontros presenciais prévios à extensão para discussão da temática e organização das atividades extensionistas. Em sequência foram realizados três encontros em Instituição Não Governamental que recebe mulheres em situação de vulnerabilidade. Os temas abordados pelo projeto envolveram além da questão do que é ser mulher, mas principalmente a violência de gênero e a pobreza menstrual.
Telessaúde Covid: caracterização sociodemográfica, clínico-epidemiológica e indicadores do telemonitoramento em Viçosa-MG
Authors: FREITAS Brunnella Alcantara Chagas de , PRADO Mara Rúbia Maciel Cardoso do , FIALHO Wilmara Lopes , HENRIQUES Bruno David , SOUZA Lívia Pereira de , DUTRA Thais Souza , LADEIRA William Carvalho Xavier , GONÇALVES Arthur Rezende , PARDIN Clara Lacerda , FREITAS Frederico Alcantara Chagas de , ASSIS Gabriela Barros de , MACIEL Henrique Carvalho , VIANA Lucas Macedo Pereira , FARIA Luna Lila Fernandes de , ANDRADE Maria Luisa Cruz , DIAS Marina Diniz , FREITAS Myrella Lacerda de , NUNES Otávio Ferreira , AVARALÉ Rodrigo Alfonso Sanmartin , OLIVEIRA Thales Nascimento de
Published: July 2023

Em 2020, a Universidade Federal de Viçosa e a Gestão Municipal implementaram o projeto de extensão Telessaúde Covid para o enfrentamento da pandemia. O objetivo é fazer uma análise descritiva dos quatorze meses de atuação do projeto. Realizou-se análise descritiva da caracterização sociodemográfica, clínico-epidemiológica e indicadores do serviço. Foram atendidos 6.898 pacientes, predominando o gênero feminino e adultos jovens. Os sinais e sintomas mais frequentes foram cefaleia, tosse, coriza, dor de garganta, dor muscular e febre. O RT-PCR foi o teste realizado pela maioria e 31,6% dos pacientes foram positivos. O serviço concluiu o encerramento de 91,5% dos atendimentos. O Telessaúde Covid foi relevante para o contingenciamento da Covid-19, com número expressivo de atendimentos, e contemplou a missão social da universidade pública, transformando o modelo assistencial e reorientando o processo de formação e ação profissional de estudantes e profissionais de saúde.
The development of simultaneous transducer ultrasonic with dual-transducer to measure flow velocity in the pipe
Authors: Wiranata Lalu Febrian , Kurniadi Deddy
Published: July 2023

There are still several obstacles to calculating fluid flow rate measurement on custody transfer, such as the distribution of one-phase fluid flow rate, less sTable pressure, and fluid flow rate changes, which are still the main problems in the process of a measuring system. To calculate the flow rate of one phase fluid, there is a method often used, namely transit time. In practice, the transit time works to send the ultrasonic pulse from upstream to downstream, which had to have a delay because the transducer must switch the function of a transducer to become transmitter or receiver. So, this paper proposed a new strategy of measurement multipath ultrasonic flowmeter (UFLW) with a simultaneous transit time method using a dual transmitter and receiver. The simultaneous method is a measuring technique that utilizes a pair of ultrasonic transducers as both trigger and receiver. The first transducer serves as the transmitter, while the second functions as the receiver, capturing the signal at the same time without changing their positions or roles. In order to implement the configuration setup, let’s try to use 3 paths configuration with 6 pairs of transducers, 3 on the upstream and 3 on the downstream. To estimate the flow velocity, let’s use long short-term memory (LSTM), which is one of the recurrent neural networks (RNN) architectures in the deep learning algorithm, and to evaluate the performance, let’s use the Bland-Altman plot and root mean squared error (RMSE) and validation loss of the LSTM model. The result shows RMSE 0.289 from the actual flow velocity, which means an LTSM with simultaneous multipath ultrasonic can reduce the error between prediction and actual measurement
Comparison of queen honey bee colony migration with various MPPTs on photovoltaic system under shaded conditions
Authors: Aripriharta Aripriharta , Bayuanggara Triawan Waskita , Fadlika Irham , Sujito Sujito , Afandi Arif Nur , Mufti Nandang , Diantoro Markus , Horng Gwo-Jiun
Published: July 2023

Shaded conditions cause a decrease in the performance of photovoltaic (PV) systems. In this situation, the power versus voltage curve shows two maximum power points, namely local (LMPP) and global (GMPP). The main challenge for extracting the maximum power from a PV system during shading conditions is the existence of a false maximum or LMPP along with a true maximum or GMPP. Traditional maximum power point tracking (MPPT) has faced hurdles in overcoming the situation. Therefore, this paper describes the implementation of Queen Honey Bee Migration (or QHBM for short) to track GMPP of PV systems, which called QHBM MPPT. The highlight of this paper is the simulation results of QHBM MPPT on PV systems under various shading conditions.

We implemented QHBM MPPT on a boost converter installed on a 1200 Wp PV system. We conducted a simulation using MATLAB® with five scenarios which aim to show the various shadows that PV systems might encounter in reality. The MPPT QHBM is tested repeatedly and then the average value is taken to measure performance in MPP tracking. The average value is used to calculate tracking efficiency, number of iteration or convergence time. We also compared QHBM with other methods, namely incremental conductance (IC) and Particle Swarm Optimization (PSO). The results obtained show that the QHBM and PSO MPPTs outperform the IC MPPT in terms of efficiency, convergence time and the number of iterations. IC MPPTs oscillate under shading conditions since no knowledge of GMPP. Both PSO and QHBM MPPTs know GMPP from scouts or particles, respectively. Therefore, PSO and QHBM MPPTs are better than IC MPPT in various shading cases
Procjene povezanosti s prirodom učenika, učitelja i roditelja u Hrvatskoj i Sloveniji
Authors: Anđić Dunja
Published: July 2023

Aktualna interdisciplinarna istraživanja ukazuju na vezu između emocionalnog odnosa prema prirodi i čimbenika koji su rezultat suvremenih načina života poput nedostatnog kretanja i boravka u prirodi i pretjerane uporabe informacijsko-komunikacijskih tehnologija. Ti se čimbenici često dovode i u svezu sa zdravim razvojem djece školske dobi. U literaturi ‘povezanost s prirodom’ najčešće se opisuje kao pojam kojim se mjeri emocionalni i afirmativni odnos čovjeka i prirode. Istraživanje je provedeno na uzorku ispitanika koje su činili učenici osnovne škole, njihovi roditelji i učitelji u osnovnim školama Hrvatske i Slovenije (N=1345). U istraživanju je kao mjerni instrument korištena adaptirana skala Mjera povezanosti s prirodom (Chang i Monroe, 2012). Utvrđeno je da se povezanost s prirodom procjenjuje visokim rezultatima, ali i da ne postoji statistički značajna korelacija procjena povezanosti s prirodom učenika, roditelja i učitelja u Hrvatskoj, već samo kod slovenskih ispitanika. Implikacije rezultata istraživanja ogledaju se u promišljanju ove problematike za daljnja istraživanja u odgoju i obrazovanju.
The role and relevance of nutritional diagnosis in pediatric oncology
Authors: Vashura A. Yu. , Kucher M. A. , Kovtun T. A. , Alymova Yu. A. , Litvinov D. V. , Zubarovskaya L. S. , Kulagin A. D.
Published: July 2023

In the Russian Federation the incidence of cancer remains high. Depending on the nosology of the tumor, the probability of malnutrition during primary hospitalization may be 10-50%, and during treatment it may reach 100%. Undernutrition and obesity are independent factors of poor prognosis, reducing the overall effectiveness of treatment. At the same time, the diagnosis of nutritional status (NS) in pediatric oncology is not clearly regulated, which, in the presence of a large number of factors affecting the functioning of the digestive, nervous, endocrine and other systems, creates prerequisites for untimely recognition of nutritional disorders and, accordingly, inadequate nutritional support. Taking into account the mentioned tendencies above it is of great value to establish the foundations for recommendations on the assessment of NS and for making nutritional diagnosis in pediatric oncology. In order to highlight and resolve this challenge the interpretation of clinical aspects, advantages and disadvantages of existing screening scales for NS assessing, anthropometric indicators, methods for body composition evaluation, eating disorders classification according to the World Health Organization, the International Classification of Diseases 10 revision and specialized medical associations was carried out. Based on modern convictions regarding the pathogenesis of protein-energy malnutrition and cachexia, side effects and complications of antitumor treatment, available tools for assessing NS, their systematization, a unified nutritional diagnosis structure was formed. It includes: NS screening, nutritional history, anthropometry dynamics, evaluation of the gastrointestinal tract state and the presence of metabolic disorders, alimentation level, determination of nutritional risk factors. NS is a complex indicator and its reflection can be a nutritional diagnosis, which will potentially allow determining the current NS state, predicting the risks of malnutrition developing, implementing rational nutritional support, and thus improving the effectiveness of cancer treatment.
Discussion article: do we understand the role of local treatments after oligoprogression of ovarian cancer on PARP inhibitors?
Authors: Rumyantsev A. A. , Zarenkova A. K. , Kirsanov V. Yu.
Published: July 2023

The development of poly(ADP‐ribose) polymerase (PARP) inhibitors has been the most significant breakthrough in the treatment of advanced ovarian cancer over recent decades, with olaparib being the first drug of this class. The drug showed its efficacy at many stages of the treatment of various oncological diseases, but its maximum clinical efficacy is demonstrated in the initial treatment of BRCA-associated or HRD-positive ovarian cancer. In the phase III SOLO1 (n = 391) and PAOLA-1 (n = 806) clinical trials, treatment with olaparib reduced the relative risk of disease progression by 67% and 59%, and the risk of death by 45% and 38%, respectively. At the same time, the treatment of patients with disease progression after therapy with PARP inhibitors causes reasonable concerns in clinicians, which is associated with many aspects, primarily with the lack of individually developed approaches to the management of this category of patients. This discussion article through the example of the treatment of a particular patient allows to summarize the current data on the features of the tumour process after disease progression on PARP inhibitors and possible ways to resolve the issue of drug resistance in such patients. In the clinical case under discussion, the maintenance therapy with olaparib after combination treatment in a 50-year-old woman with metachronous multiple primary BRCA-associated malignancies (breast cancer in 2005, ovarian cancer in 2018) allowed to achieve a 2-year cancer remission, after which the oligoprogression of ovarian cancer was observed. PET-CT showed a left iliac lymph node metastasis without other progressive manifestations of the disease, after which a left laparoscopic iliac lymphadenectomy was performed, and the olaparib therapy was continued until progression or intolerable toxicity. The duration of olaparib therapy from the date when the local treatment was performed is 23 months as of this writing. The article states the detailed rationale behind choosing the non-standard management and presents the results of recent studies that support the decisions made.
The role of irrigation salt solutions with silver ions in the treatment and prevention of ENT diseases in children
Authors: Karpishchenko S. A. , Rodneva Yu. A.
Published: July 2023

ENT diseases are one of the most common reasons for visiting a doctor, especially in paediatric practice. The issue of interdisciplinary interactions between otorhinolaryngologists and paediatricians, their consistency in choosing therapy is extremely important. About 90% of morbidity rates relate to acute infectious respiratory viral etiology, which is characterized by high transmissibility and variability of manifestations. Particular attention should be paid to children attending preschool facilities, as they can catch acute respiratory viral infections up to 8 times a year, and 10-15% of them up to 12 times a year, which is 2 times more often than children who do not attend school, kindergarten, or any other educational facilities. The premature and unjustified prescription of antibacterial drugs, both local and systemic, remains a serious problem in the choice of therapy, which leads to increased number of antibiotic-resistant bacterial strains. Therefore, the issue of prevention and rational therapy, improvement of its effectiveness by the use of safe drugs appears relevant. The article points out that the irrigation-elimination therapy has been and remains the foundation of the prevention and treatment of diseases of the nasal cavity, paranasal sinuses and nasopharynx. The effectiveness and safety of this therapy has been studied and proven in the studies, and the inclusion of irrigation-elimination therapy in the international consensus documents such as EPOS 2012 and ARIA 2008 allows it to be widely used for the treatment of various ENT pathologies. It should be noted that availability of irrigation salt solutions with silver ions have significantly added to the possibilities of keeping the use of more aggressive drugs to a minimum, especially if the course of the disease is not complicated. Aquanasal drug containing natural Altai mineral water rich in silver ions is one of the commonly used drugs of a similar character with a wide range of indications, which has anti-inflammatory, anti-edematous, antimicrobial, antifungal and antiviral effects.
Influence of a combined interferon-alpha-containing drug on the course of respiratory diseases in frequently ill children
Authors: Zakirova A. M. , Moroz T. B. , Shayapova D. T. , Kadriev A. G. , Palmova L. Yu. , Rashitova E. L. , Zotova A. E. , Khairullina L. A. , Kiselev R. P. , Kadriev D. A.
Published: July 2023

Introduction. Acute respiratory viral infections hold a dominant place in the infectious diseases pattern. There are many drugs that can affect separate arms of the immune response.

Aim. To analyze the effectiveness of the systemic use of a combined drug containing interferon-α-2b and a complex immunoglobulin preparation in the treatment of respiratory diseases in frequently ill children.

Material and methods. We examined 103 children aged 2-12 years. Upon admission, the children were treated with a combined drug containing interferon a-2b and a complex immunoglobulin preparation (CIP) (Kipferon®) rectally. Children in the control group received standard therapy.

Results. Children were admitted to the hospital in the first days of the disease (66.02%), mainly in the moderate form of the disease (96.12%). 81.55% had symptoms of intoxication, catarrhal phenomena and respiratory syndrome. Comparing the time from the onset of the disease when prescribing IFN-α-2b to children, their significantly significant differences were established. Introduction in the early stages of the disease contributes to a faster elimination of all symptoms: fever stopped on average (M ± SD) after 1.76 ± 0.33 and 2.05 ± 0.29 days, respectively, from the moment of admission to the hospital, which was on average 2 days less than in the control group. The transition to a productive cough in the main group occurred on average (M ± SD) after 3.25 ± 0.27 days, in the comparative group - after 5.23 ± 0.31, in the control group - after 8.19 ± 0.42 days. In patients of the main and comparative groups, the length of stay in the hospital was significantly shorter - on average (M ± SD) 8.04 ± 0.81 days than in the control group - 10.56 ± 1.42 days. Hematological parameters returned to normal at an earlier time.

Discussion. Rectal route of recombinant IFNi-a2b delivery as suppositories is substantiated with regard to etiopathogenesis and immunology.

Conclusion. The article presents the outcomes of the clinical use of Kipferon® as part of the combination therapy and prevention of complications of acute respiratory viral infections in children: reduced duration of intoxication, fever, faster improvement of the auscultatory status of the lungs, improvement of immune status indicators.
Glycemic control in children receiving glucocorticoid therapy
Authors: Vitebskaya A. V. , Popovich A. V. , Afonina E. Yu. , Batyreva O. V.
Published: July 2023

Hyperglycemia is a well-known side effect of glucocorticoid (GC) therapy. GC treatment can lead to steroid diabetes mellitus (DM) manifestation. Glycemic control is essential for patients receiving GC. Three clinical cases of carbohydrate metabolism impairment (hyperglycemia) in children receiving GC needing glycemic control were described. In the 1st case transient fasting hyperglycemia up to 8.3 mmol/l (while normal data after meals) was detected during 3 days after start of GC pulse-therapy of bronchial asthma. Normalization of glycaemia was evident since the 4th day in spite of GC therapy continuing for 6 days. In the 2nd case transient hyperglycemia while pulse-therapy of juvenile arthritis with systemic onset was detected on the 3rd day (7.25 mmol/l), GC in tablets was added, pulse-therapy with gradually dose reduction continued 9 days else. Hyperglycemia (up to 11.7 mmol/l) persisted for 4 days, then glycaemia normalization was detected in spite of continuing GC therapy (50 mg or 0.7 mg/kg). In the 3rd case steroid DM in a patient with juvenile systemic scleroderma, familial history of DM type 2, and obesity manifested after 2 months of treatment with GC tablets (35 mg or 0.6 mg/kg), metformin was prescribed. While reduction of GC dose trend to glycaemia normalization was seen. In 4 months after cessation of GC impaired glucose tolerance and insulin resistance were diagnosed.

Glycemic control is essential for patients receiving GC. Hyperglycemia while receiving GC can be both transient or persistent. Risk of steroid DM is higher in cases of family history of DM type 2, obesity, high doses, and prolonged GC treatment. In patients at-risk of DM type 2 impairment of carbohydrate metabolism can persist after cessation of GC; this needs repeated examination.
Organization clinical decision-making programs in the local practice of the region: problematic issues that determine the choice of therapy in the progression of endometrial cancer
Authors: Goryainova A. Yu. , Leonov M. G. , Murashko R. A. , Tsirulnikova O. S. , Chukhrai O. Yu.
Published: July 2023

Introduction. For the treatment of uterine body cancer (UBC), modern oncologists have at their disposal clinical recommendations of scientific communities, the set of drug options in which is represented by a limited range of drugs that have not been studied enough (phase II studies, no more than 52 patients in each). There is an obvious lack of information about clinical routine data systematization algorithms that describe the molecular biological features of the tumor, its prevalence, patient characteristics, existing treatment models, and form a decision-making program when planning the treatment of UBC patients.Aim. Тo develop an algorithm for routing patients with UBC on the territory of the Krasnodar Region in the existing conditions for organizing medical care and human resources.Materials and methods. Local observational retrospective study. Sources – medical records. The data were collected by the co-authors of the article in the course of daily clinical activities. Information from the medical records of 72 patients with endometrial cancer who were referred for microsatellite instability (MSI) testing at the Oncological Dispensary of Krasnodar from 01/01/2021 to 11/16/2022 was analyzed to determine the possibility of receiving immuno/immuno-targeted therapy in the second and subsequent lines medicinal treatment.Results. In the Krasnodar Oncological Dispensary all the therapy options specified in the clinical guidelines were used. One line of systemic therapy for a common disease was received by 61 patients out of 72, only 41 patients received the second line, and only 19 patients received the third line. Five patients received the immunotargeted combination in the second line and 3 in the third. One patient received immunotherapy with pembrolizumab in the third line. One patient received immunotherapy with pembrolizumab in the third line. An analysis of the factors influencing the possibility of receiving this therapy showed the importance of timely genetic testing of MSI, as well as related organizational issues, such as the ability to quickly receive treatment and ensure appropriate follow-up of patients.Conclusions. Based on the study, low awareness of clinicians about the possibility and necessity of early testing for the presence of MSI in an endometrial tumor was revealed. The organization of delivery of material from clinics that have a territorial remoteness, insufficient access to patient consultations by related specialists, and low patient compliance limit the introduction of modern methods of therapy for UBC patients. Establishing a system of close professional interaction between physicians will contribute to a wider introduction of new methods of diagnosis and treatment of UBC patients.
Features of drug therapy for functional gastrointestinal disorders in children of preschool and primary school age
Authors: Khavkin A. I. , Novikova V. P. , Gurova M. M.
Published: July 2023

The article explores modern concepts about functional gastrointestinal disorders in children, considers features of the classification according to the Rome criteria and Russian clinical guidelines, and presents the evolution of views in the context of understanding the general pathophysiological mechanism as impaired “gut-brain” interactions, which leads to dysmotility in different parts of the gastrointestinal tract, visceral hypersensitivity, changes in the local immune system functions, dysbiosis of the gut microbiota and a failure of the central nervous system to process signals. Dysregulation of the central nervous system and the enteric nervous system causes functional gastrointestinal disorders with pain syndrome: irritable bowel syndrome, functional dyspepsia and centrally mediated abdominal pain syndrome. In addition, the article discusses the Russian version of the guidelines due to differences in the diagnostic instrumental and laboratory facilities, as well as national peculiarities of marketing authorization, indications and contraindications for drug use in children. Subject to understanding of the mechanisms of functional gastrointestinal disorders in children, the authors presented information on the role of trimebutine, a universal motility regulator of different parts of the gastrointestinal tract, in the development of functional gastrointestinal disorders, as well as modern approaches to their prevention and correction using a drug of proven efficacy. Numerous national and foreign studies proved the efficacy of trimebutine in hyperkinetic and hypokinetic movement disorders, decreased gastric evacuation function, and impaired gallbladder contractile function in patients with both hypomotor and hypermotor types of functional disorders. The accumulated experience determines the prospects for its use in pediatric practice.
Prospects for the use of adequate external therapy for atopic/allergic dermatitis in children
Authors: Zakirova A. M. , Shayapova D. T. , Vakhitov Kh. M. , Palmova L. Yu. , Kadriev A. G. , Rashitova E. L. , Kadriev A. A. , Karamanian O. V.
Published: July 2023

The article focuses on the most frequent skin diseases in young children. Atopic/allergic dermatitis is one of the most common diseases in children. Approximately 45% of patients develop their first symptoms within the first 6 months after birth, 60% show the onset of atopic dermatitis during the first year of life and 80-85% at the age of 1 to 5 years. The article also speaks about the issue of allergic contact dermatitis (diaper rash in newborns). The disease represents non-specific inflammatory skin changes in the contact area in infants, the onset of which occurs mostly at the age of 1 to 15 months. The factors responsible for causing these diseases, the pathogenesis of their development and the potential of topical therapy mainly targeted at the reduction of clinical manifestations and frequency of exacerbations, improvement of the quality of life and prevention of infectious complications are considered. As an initial treatment, the authors consider a drug containing methylprednisolone aceponate with ceramides of domestic manufacturing. Its effectiveness and safety in the combination therapy of young children suffering from atopic/allergic and contact dermatitis may be evaluated in clinical practice. Clinical case reports of treatment of children with dermatitis of various etiologies aged from 4.5 months up to 3 years are presented. The outcomes of the use of Komfoderm K in children with AD demonstrated a significant decrease in the severity of inflammation, reduction of the skin lesion area and the intensity of symptoms, decreased need for additional intake of antihistamines and anti-inflammatory drugs, and the ability to achieve stable clinical remission.
Esophagoprotective agent in the treatment of gastroesophageal reflux disease in children
Authors: Pakhomovskaia N. L.
Published: July 2023

Gastroesophageal reflux disease (GERD) prevalence in children and adolescents is estimated as high. GERD has a wide variety of clinical signs that significantly reduce the patients' quality of life. Typical symptoms include heartburn, belching, and regurgitation (regurgitation). Extraesophageal symptoms are mainly represented by complaints indicating the involvement of the respiratory, ENT organs, and oral cavity organs in the process. In addition, gastroesophageal reflux disease is a major risk factor for Barrett's esophagus and esophageal adenocarcinoma. The main factors predisposing to the development of gastroesophageal reflux disease in children are obesity, overeating, congenital anomalies of the esophagus, surgical interventions at the cardioesophageal junction, immature autonomic nervous system, nervous system diseases, administration of certain drugs, as well as vices such as smoking and alcohol drinking in adolescence. The mainstay of treatment of gastroesophageal reflux disease is antisecretory therapy with proton pump inhibitors. However, some patients using proton pump inhibitors at a standard dosage fail to achieve the clinical and endoscopic remission of the disease. The causes of the gastroesophageal reflux disease refractoriness to the adequate therapy most often include impaired barrier function and increased esophageal mucosal permeability. The use of esophagogastroprotective agents contributes to the optimization of therapy of gastroesophageal reflux disease and aims at achieving the disease remission in a larger number of patients. Clinical case reports of diagnosis and treatment of patients aged 12 and 16 years with gastroesophageal reflux disease are presented. The use of the esophagoprotective agent provided rapid relief of both esophageal and extraesophageal symptoms of the gastroesophageal reflux disease. In addition, complete healing of erosive esophagitis was achieved during its therapy.
Features of diagnosis and therapy of febrile syndrome in young children
Authors: Kholodova I. N. , Tvorogova T. N. , Kholodov D. I. , Vasilyev Yu. V. , Zaydenvarg G. E.
Published: July 2023

In this article, the authors raise the issue of the treatment of febrile conditions in young children. At the same time, the emphasis is on the definition of feverish conditions, etiopathogenesis, and the possibilities of modern diagnostics, taking into account various types of constitution in children. The authors provide their own data, based on many years of experience in monitoring children of the main three constitutional types according to M.S. Maslov. The features of fever therapy in children, indications and contraindications to the appointment of antipyretic drugs are discussed, emphasis is placed on side effects and contraindications of these drugs for infants. In recent years, the attention of many doctors has been drawn to the theory and practice of bioregulatory medicine, which is a branch of modern medicine that uses the experience of using natural remedies. The data of Russian and international researchers proving the expediency and effectiveness of treating fever symptoms with these drugs are presented. Special attention is paid to the drug Viburcol, which can be used for children starting from birth, which is undoubtedly important, since it is for children of the first year of life that safe and effective means are needed due to increased sensitivity to the toxic effects of all medicines. It is shown that the use of Viburcol suppositories in children is advisable, allows you to achieve the desired effect without any toxic and side effects. The authors, referring to international and Russian experience, recommend Viburcol for the treatment of fever, excitability, anxiety, pathological teething, as well as in the preparation and management of children during vaccination.