bluuebunny/crossref_metadata_2025 huggingface dataset:
ChemInform Abstract: One‐Pot Synthesis of Indoles and Aniline Derivatives from Nitroarenes under Hydrogenation Condition with Supported Gold Nanoparticles.
Authors: Yamane Yoshihiro , Liu Xiaohao , Hamasaki Akiyuki , Ishida Tamao , Haruta Masatake , Yokoyama Takushi , Tokunaga Makoto
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Intramolecular Photochemical Cross‐Coupling Reactions of 3‐Acyl‐2‐haloindoles and 2‐Chloropyrrole‐3‐carbaldehydes with Substituted Benzenes.
Authors: Lu Shen‐Ci , Zhang Xi‐Xia , Shi Zong‐Jun , Ren Yu‐Wei , Li Bing , Zhang Wei
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Reaction of 3‐(Polyfluoroacyl)chromones with Hydrazines: New Regioselective Synthesis of RF‐Containing Pyrazoles.
Authors: Sosnovskikh V. Ya. , Irgashev R. A. , Moshkin V. S. , Kodess M. I.
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Chemistry of α,β‐Ditosyloxyketones: New and Convenient Route for the Synthesis of 1,4,5‐Trisubstituted Pyrazoles from α,β‐Chalcone Ditosylates.
Authors: Prakash Om , Sharma Deepak , Kamal Raj , Kumar Rajesh , Nair Reshmi R.
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Simple Approach to Pyrazol‐3‐ones via Diazenes.
Authors: Burja Bojan , Kocevar Marijan , Polanc Slovenko
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of 2‐Aroyl‐1‐hydroxy‐4,5‐dimethylimidazoles by Reaction of 3‐Hydroxyamino‐2‐butanone Oxime with Arylglyoxals.
Authors: Amitina S. A. , Tikhonov A. Ya. , Grigor'ev I. A. , Gatilov Yu. V. , Selivanov B. A.
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Organocatalytic Asymmetric Synthesis of Protected α,β‐Diamino Acids.
Authors: Shi Zugui , Yu Peiyuan , Chua Pei Juan , Zhong Guofu
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Ligand‐Free Copper‐Catalyzed Synthesis of Substituted Benzimidazoles, 2‐Aminobenzimidazoles, 2‐Aminobenzothiazoles, and Benzoxazoles.
Authors: Saha Prasenjit , Ramana Tamminana , Purkait Nibadita , Ali Md Ashif , Paul Rajesh , Punniyamurthy Tharmalingam
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Preparation of Hydantoins by Catalytic Oxidative Carbonylation of α‐Amino Amides.
Authors: Dumbris Seth M. , Diaz Delmy J. , McElwee‐White Lisa
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of N‐Substituted‐2‐aminobenzothiazoles by Ligand‐Free Copper(I)‐Catalyzed Cross‐Coupling Reaction of 2‐Haloanilines with Isothiocyanates.
Authors: Shen Guodong , Lv Xin , Bao Weiliang
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Regioselective Nitroalkylation of the 1‐Methyl‐2‐quinolone Framework.
Authors: Asahara Motoki , Ohtsutsumi Masaki , Ariga Masahiro , Nishiwaki Nagatoshi
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Short Path to the 1,3‐cis‐Substituted Core Skeleton of Tetrahydroisoquinolines
Authors: Tuan Le Anh , Kim Guncheol
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Reactions of 3‐(Polyfluoroacyl)chromenones with Heterocyclic Amines: Novel Synthesis of Polyfluoroalkyl‐Containing Fused Pyridines.
Authors: Kotljarov Anton , Iaroshenko Viktor O. , Volochnyuk Dmitriy M. , Irgashev Roman A. , Sosnovskikh Vyacheslav Ya.
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Palladium‐Catalyzed Cyclization/Cyclopropanation Reaction for the Synthesis of Fused N‐Containing Heterocycles.
Authors: Nandi Sukla , Ray Jayanta K.
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Multicomponent One‐Pot Solvent‐Free Synthesis of Functionalized Unsymmetrical Dihydro‐1H‐indeno[1,2‐b]pyridines.
Authors: Samai Subhasis , Nandi Ganesh Chandra , Kumar Ram , Singh M. S.
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Functional Sulfur‐Containing Compounds. Part 14. Study of Intramolecular Cyclization of 2‐Organylthio‐, 2‐Organylsulfinyl‐, and 2‐Organylsulfonylnicotinic Acid Esters and Nitriles upon Action of a Base.
Authors: Kalugin V. E. , Shestopalov A. M.
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Diels—Alder Reactions Between Acrolein N,N‐Dimethylhydrazone and N‐Benzylated Benzotriazole‐, Indazole‐ or Indole‐4,7‐diones.
Authors: Marminon Christelle , Fenet Bernard , Mignosi Valeria , Terreux Raphael , Nebois Pascal
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Convenient Selective Synthesis of Pyrano[2,3‐d]pyrimidines
Authors: Litvinov Yu. M. , Shestopalov A. M.
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Norbornane Series Tetra‐ and Hexahydropyrimidines.
Authors: Shafikova E. A. , Petrov D. V. , Sapozhnikova T. A. , Baschenko N. J. , Dokichev V. A.
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Facile Synthesis and Biological Activity of Novel Tetrahydrobenzo[4′5′]thieno[3′,2′:5,6]pyrido [4,3‐d]pyrimidin‐4(3H)‐ones.
Authors: Ren Qingyun , Liang Yong‐Ju , He Hongwu , Fu Liwu , Gu Yucheng
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Improved Method for Preparation of Dibenzocrown‐Containing 4H‐Pyran‐4‐one (V) and Synthesis of Merocyanine Dyestuffs [cf. (VI)] from It.
Authors: Poronik Ye. M. , Shandura M. P. , Tolmachev A. I. , Kovtun Yu. P.
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Acyclic Ketene Aminal Phosphates Derived from N,N‐Diprotected Acetamides: Stability and Cross‐Couplings.
Authors: Simas Alessandro B. C. , de Sales Daniel L. , Pais Karla C.
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Two New Sesquiterpene Glucosides from Gymnaster koraiensis.
Authors: Lee Il Kyun , Kim Ki Hyun , Ryu Shi Yong , Lee Kang Ro
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Triflic Acid‐Promoted Formylation of Ceramide (I) in Dimethylformamide.
Authors: Chiang Liwu , Pan Sider , Lo Jemmau , Yu Chungshan
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Total Synthesis of Platensimycin and Related Natural Products.
Authors: Nicolaou K. C. , Li Ang , Edmonds David J. , Tria G. Scott , Ellery Shelby P.
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: 13‐Bromomonocillin I: A New WNT‐5A Expression Inhibitor Produced by Pochonia chlamydosporia var. chlamydosporia.
Authors: Shinonaga Hideki , Sakai Noriyoshi , Nozawa Yuriko , Ikeda Akiko , Aoki Mari , Kawashima Akira
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Chemical Domain of QSAR Models from Atom‐Centered Fragments.
Authors: Kuehne Ralph , Ebert Ralf‐Uwe , Schueuermann Gerrit
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Clar Theory for Radical Benzenoids.
Authors: Misra Anirban , Schmalz T. G. , Klein D. J.
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Identification of Novel Non‐Hydroxamate Anthrax Toxin Lethal Factor Inhibitors by Topomeric Searching, Docking and Scoring, and in vitro Screening.
Authors: Amin Elizabeth A. , et al. et al.
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Infiltration of Water Molecules into the Oseltamivir‐Binding Site of H274Y Neuraminidase Mutant Causes Resistance to Oseltamivir.
Authors: Park Jin Woo , Jo Won Ho
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Effect of Ligand‐Based Tautomer and Protomer Prediction on Structure‐Based Virtual Screening.
Authors: Kalliokoski Tuomo , Salo Heikki S. , Lahtela‐Kakkonen Maija , Poso Antti
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Docking of Hydroxamic Acids into HDAC1 and HDAC8: A Rationalization of Activity Trends and Selectivities.
Authors: Ortore Gabriella , Di Colo Francesco , Martinelli Adriano
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Scoring Ensembles of Docked Protein: Ligand Interactions for Virtual Lead Optimization.
Authors: Paulsen Janet L. , Anderson Amy C.
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Photoluminescence Properties of Ba2ZnSi2O7: Eu2+, Re3+ (Re: Dy, Nd) Long Lasting Phosphors Prepared by the Combustion‐Assisted Synthesis Method.
Authors: Yao Shanshan , Li Yuanyuan , Xue Lihong , Yan Youwei
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Development of Supramolecular Machines Allowing for Mechanical Communication Between Molecules.
Authors: Kinbara Kazushi
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Self‐Assembled Porphyrin Nanostructures
Authors: Medforth Craig John , Wang Zhongchun , Martin Kathleen Ewing , Song Yujiang , Jacobsen John Lewis , Shelnutt John Allen
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Mechanism of Enantioselection in Rh‐Catalyzed Asymmetric Hydrogenation. The Origin of Utmost Catalytic Performance
Authors: Gridnev Ilya D. , Imamoto Tsuneo
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Thionocarbamates on Carbohydrate Scaffolds: From Synthesis to Bioactivity
Authors: Simao Ana Catarina , Rousseau Jolanta , Silva Sandrina , Rauter Amelia Pilar , Tatibouet Arnaud , Rollin Patrick
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Anomeric Effects in Pyranosides and Related Acetals
Authors: Gerber‐Lemaire Sandrine , Vogel Pierre
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: 3,3,4,4‐Tetraethoxybutyne — An Excellent Starting Material for the Synthesis of a Range of Functionalized Compounds
Authors: Sydnes Leiv K. , Holmelid Bjarte , Valdersnes Stig , Sengee Myagmarsuren , Boman Kjartan
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Artificial Metalloenzymes: Combining the Best Features of Homogeneous and Enzymatic Catalysis
Authors: Pordea Anca , Ward Thomas R.
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Chemistry of 2‐Arylhydrazonals
Authors: Abdelhamid Ismail Abdelshafy , Nasra Miead Adel , Elnagdi Mohamed Hilmy
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Chemical Biology of Inflammatory Cytokine Signaling
Authors: Kataoka Takao
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Development of Dinuclear Vanadium Catalysts for Enantioselective Coupling of 2‐Naphthols via a Dual Activation Mechanism
Authors: Takizawa Shinobu
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Direct Conversion of Carbon—Hydrogen into Carbon—Carbon Bonds by First‐Row Transition‐Metal Catalysis
Authors: Kulkarni Amol A. , Daugulis Olafs
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Foldamers with Helical Cavities or Binding Complementary Guests
Authors: Juwarker Hemraj , Suk Jae‐min , Jeong Kyu‐Sung
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Search of Novel Bioactive Natural Products from Plant Sources — Novel Structures and Biological Activities
Authors: Furukawa Hiroshi
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Development of Rare Metal‐Free Synthetic Method Using New Iodine Reagents
Authors: Dohi Toshifumi
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Maya Blue as a Nanostructured Polyfunctional Hybrid Organic—Inorganic Material: The Need to Change Paradigms.
Authors: Domenech Antonio , Domenech‐Carbo Maria Teresa , Sanchez del Rio Manuel , Vazquez de Agredos Pascual Maria Luisa , Lima Enrique
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Polymeric Rotaxanes
Authors: Harada Akira , Hashidzume Akihito , Yamaguchi Hiroyasu , Takashima Yoshinori
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Helical Polymers: Synthesis, Structures, and Functions
Authors: Yashima Eiji , Maeda Katsuhiro , Iida Hiroki , Furusho Yoshio , Nagai Kanji
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Recent Developments in the Methods and Applications of the Bond Valence Model
Authors: Brown Ian David
Published: March 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Berührungslose Überwachung mehrphasiger Mikrokapillarströmungen anhand ihrer dielektrischen Eigenschaften
Authors: Ghaini A. , Agar D. W. , Franzke J. , Mescher A.
Published: March 2010

Durch Messung der Permittivität (dielektrische Leitfähigkeit) konnte für flüssig‐mehrphasige Pfropfenströmungen (engl.: slug flow) im Kapillar‐Mikroreaktor ein neues Verfahren zur Überwachung entwickelt werden. Die berührungslose Messmethode bedarf eines Elektrodenpaares am Mikrokanal und einer Signalverarbeitung mittels eines Lock‐In Verstärkers. Es wurden verschiedene Elektrodenkonfigurationen für fünf flüssig‐zweiphasige Stoffsysteme über einen breiten Bereich von Phasendurchsatzverhältnissen und Strömungsgeschwindigkeiten untersucht. Es zeigte sich, dass die Messung der Permittivität der Strömung gut geeignet ist, die Phasen in der Kapillare zu unterscheiden und somit Störungen eines gewünschten Strömungszustandes zu identifizieren. Ferner ist eine Sensitivität des Messsignals auf die Strömungsgeschwindigkeit zu beobachten, womit die Methode Entwicklungspotenzial zu einem verhältnismäßig wenig aufwändigen Verfahren zur Überwachung mehrphasiger Strömungen in Mikrokanälen aufweist.
PAT und QbD im regulatorischen Umfeld der Pharmazeutischen Industrie
Authors: Schmidt‐Bader T.
Published: March 2010

Die PAT‐Initiative der FDA (U. S. Food and Drug Administration) und der QbD‐Ansatz der ICH (International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use) stellen Methoden und Tools für die Entwicklung und Herstellung sicherer und qualitativ hochwertiger Arzneimittel zur Verfügung. Durch eine stringent systematische Vorgehensweise können Forschungs‐ und Entwicklungsvorhaben wie auch die Herstellung von Arzneimitteln beschleunigt und zielgerichteter umgesetzt werden. Ein konsequentes Risikomanagement, wie es PAT/QbD‐Ansätze fordern, würde über die gesamte Wertschöpfungskette der pharmazeutischen Industrie zu mehr Sicherheit und Kosteneinsparungen in den Pharmamärkten führen. Es wird erwartet, dass pharmazeutische Unternehmen, die PAT/QbD organisatorisch optimal innerhalb der eigenen Strukturen entwickeln können, in Zukunft durch schnellere Zulassungen, robustere Prozesse und optimierte Kostenstrukturen verstärkt Marktanteile gewinnen. Auf Patientenseite werden eine höhere Qualität und ein gedämpfter Kostenanstieg im Arzneimittelsektor als Pluspunkte zu verbuchen sein.
Prozess Analytische Technologie in der Biotechnologie
Authors: Herwig C.
Published: March 2010

Biotechnologische Prozesse sind durch eine enorme Komplexität von intrazellulären Wechselwirkungen charakterisiert. Prozess Analytische Technologie (PAT) soll nach Vorgabe von den Regulationsbehörden eingesetzt werden, um diese Prozesse wissenschaftlich basiert und robust zu entwickeln. Der Beitrag zeigt die Entwicklungen von PAT‐Sensoren für die Echtzeitmessung und die Notwendigkeit der Integration von PAT‐gerechten Daten in Quality by Design (QbD) durch Datenauswertung auf. PAT ist quantitativ und sollte als ein Werkzeug innerhalb von QbD verstanden werden, was außer der Echtzeitmessung auch den Weg mittels Datenauswertung zu kritischen Prozessparametern erlaubt. PAT ist daher nicht zwingend mit dem Kauf teurer Online‐Analytik gleichzusetzen. Die Kombination von Sensoren und Auswertemethoden sichert die Durchgängigkeit von der Prozessentwicklung in die industrielle Herstellung und wird die Wissenschaftlichkeit als essentiellen Bestandteil in der Bioprozessentwicklung verankern.
Ultraschallbasierte Informationsgewinnung in der Verfahrenstechnik
Authors: Hempel U. , Wöckel S. , Auge J.
Published: March 2010

Die genaue Kenntnis von Prozesszuständen zu jeder Zeit an jedem Ort ist eine Vision, der die Realität mitunter nur in unzureichendem Maße gerecht wird. Die Gründe hierfür sind vielgestaltig, technisch und ökonomisch motiviert. Sensoren für die Informationsgewinnung im Prozess sollen einfach zu installieren und wartungsfrei, robust, langzeitstabil, schnell und hoch genau messend sowie preiswert sein. Diese Forderungen sind durch die unterschiedlichen messtechnischen Prinzipien in sehr unterschiedlichem Maße erfüllbar. Welche Rolle hierbei ultraschallbasierte Sensorsysteme gegenwärtig spielen und zukünftig spielen könnten ist Gegenstand des Beitrages, der die Grundlagen des Ultraschalls kurz umreißt, Fragen des Wandlerdesigns und der Signalanalyse andiskutiert sowie einen Überblick zu den zahlreichen Applikationsmöglichkeiten von Ultraschallsensorsystemen in der Prozessindustrie gibt.
Integration der Prozessanalysentechnik in die Prozessführung: Beispiele aus der industriellen Praxis bei BASF
Authors: Schocker A. , Kleinert T.
Published: March 2010

Neue und anspruchsvolle Strategien in der Prozessführung chemischer Produktionsanlagen erfordern, dass neben klassischen Prozessparametern (Druck, Temperatur, Durchfluss) auch stoffspezifische Informationen online im Prozess gemessen werden. Die moderne Prozessanalysentechnik (PAT) eröffnet hier vielfältige Möglichkeiten mit spezifischen und unspezifischen Methoden. Die direkte Einbindung der PAT in eine Qualitätsregelung ist der konsequente Schritt hin zu einer weiter optimierten Prozessführung. Dieser Beitrag gibt einen Überblick über die PAT aus der Perspektive der Integration in die Prozessführung. Verschiedene analytische Methoden werden anhand ihrer Analysenzeiten und Taktzyklen sowie der Signalqualität und ‐verfügbarkeit für die Verwendung in der Prozessführung klassifiziert. Des Weiteren wird dargestellt, wie eine Integration in die Prozessregelung in Form von Qualitätsregelungen projektiert werden kann. Verschiedene Praxisbeispiele demonstrieren, wie sowohl kontinuierliche Messungen als auch Messsysteme mit langen Analysenzeiten für die automatisierte Steuerung der Produktionsprozesse eingesetzt werden. Mit dem Fokus auf aktuelle Entwicklungen und Trends bei der PAT werden die Potenziale für die Prozessführung aufgezeigt.
Multivariate Curve Resolution – Integration von Wissen in Chemometrische Modelle
Authors: Kessler W. , Kessler R.
Published: March 2010

In der Prozessdatenanalyse haben sich sowohl die Hauptkomponentenanalyse (PCA) als auch die Partial Least Square Regression (PLSR) als chemometrische Werkzeuge etabliert. Der wesentliche Nachteil von PCA und PLSR ist, dass die Hauptkomponenten abstrakte, sogenannte latente Variable darstellen und häufig den physikalisch chemischen Hintergrund nur ungenau widerspiegeln. Es ist deshalb wünschenswert, neue Methoden für die komplexe Datenanalyse zu entwickeln, die es ermöglichen, Basiswissen über den Prozess in die chemometrische Beschreibung zu integrieren. Die Methoden der multivariaten Kurvenauflösung (Multivariate Curve Resolution, MCR) erlauben das Einbringen von vorhandenem Wissen in die chemometrische Auswertung in Form von Nebenbedingungen. Hier werden an Hand von drei praktischen Beispielen aus der Prozessanalytik diese Möglichkeiten der MCR‐Methode aufgezeigt.
Degradation of polycyclic aromatic hydrocarbons: Model simulation for bioavailability and biodegradation
Authors: Owabor C. N. , Ogbeide S. E. , Susu A. A.
Published: March 2010

A mathematical model for a one‐dimensional convective‐dispersive solute transport in a soil matrix is presented. The interplay of linear equilibrium sorption and first order degradation were incorporated into the formulation of the model. The model took into consideration the overall effects of the solid and liquid phase mass transfer resistances. Data from experiments were analysed using the temporal moments method (MOM) and CXTFIT curve‐fitting technique. The functional parameters; dispersion coefficient, first order degradation rate constant and the retardation factor were estimated using both first and second normalised moments. The solution to the model equations was achieved by the use of the backward finite difference scheme. Results obtained showed that naphthalene was more selectively degraded than pyrene and anthracene with a residual concentration of naphthalene 1.12E − 5 mg/L, 1.48 mg/L; pyrene 3.11E − 4 mg/L, 1.58 mg/L; and anthracene 7.67E − 4 mg/L, 1.61 mg/L in the axial and radial directions, respectively. Concisely, the modeling results showed the occlusion of these compounds within the fissures and cavities of the soil particles, which renders them not readily bioavailable and thus inaccessible to microbial degradation.
Synthesis of N‐Hydroxycinnamides Capped with a Naturally Occurring Moiety as Inhibitors of Histone Deacetylase
Authors: Huang Wei‐Jan , Chen Ching‐Chow , Chao Shi‐Wei , Lee Shoei‐Sheng , Hsu Fen‐Lin , Lu Yeh‐Lin , Hung Ming‐Fang , Chang Chung‐I
Published: March 2010

Histone deacetylase (HDAC) inhibitors are regarded as promising therapeutics for the treatment of cancer. All reported HDAC inhibitors contain three pharmacophoric features: a zinc‐chelating group, a hydrophobic linker, and a hydrophobic cap for surface recognition. In this study we investigated the effectiveness of osthole, a hydrophobic Chinese herbal compound, as the surface recognition cap in hydroxamate‐based compounds as inhibitors of HDAC. Nine novel osthole‐based N‐hydroxycinnamides were synthesized and screened for enzyme inhibition activity. Compounds 9 d, 9 e, 9 g exhibited inhibitory activities (IC50=24.5, 20.0, 19.6 nM) against nuclear HDACs in HeLa cells comparable to that of suberoylanilide hydroxamic acid (SAHA; IC50=24.5 nM), a potent inhibitor clinically used for the treatment of cutaneous T‐cell lymphoma (CTCL). While compounds 9 d and 9 e showed SAHA‐like activity towards HDAC1 and HDAC6, compound 9 g was more selective for HDAC1. Compound 9 d exhibited the best cellular effect, which was comparable to that of SAHA, of enhancing acetylation of either α‐tubulin or histone H3. Molecular docking analysis showed that the osthole moiety of compound 9 d may interact with the same hydrophobic surface pocket exploited by SAHA and it may be modified to provide class‐specific selectivity. These results suggest that osthole is an effective hydrophobic cap when incorporated into N‐hydroxycinnamide‐derived HDAC inhibitors.
An in vitro Assay to Measure Targeted Drug Delivery to Bone Mineral
Authors: Jahnke Wolfgang , Henry Chrystèle
Published: March 2010

Targeted delivery of drugs to their site of action is a promising strategy to decrease adverse effects and enhance efficacy, but successful applications of this strategy have been scarce. Human bone is a tissue with unique properties due to its high hydroxyapatite mineral content. However, with the exception of bisphosphonates, bone mineral has not been targeted in a successful clinical application of drugs that act on bone, such as anti‐resorptive or bone anabolic agents. Herein we present an NMR‐based in vitro assay to measure binding affinities of small molecules to hydroxyapatite (HAP) or bone powder. Binding was shown to be specific and competitive, and the assay can be carried out in a direct binding format or in competition mode. A selection of clinically relevant bisphosphonates was ranked by their binding affinity for HAP. The binding affinity decreases in the order: pamidronate > alendronate > zoledronate > risedronate > ibandronate. The differences in binding affinities span a factor of 2.1 between pamidronate and ibandronate, consistent with previous studies. The rank order is very similar with bone powder, although the binding capacity of bone powder is smaller and binding kinetics are slower. A zoledronate derivative that lacks the central hydroxy group binds to HAP with 2.3‐fold weaker affinity than zoledronate itself. Any small molecule can be analyzed for its binding to HAP or bone powder, and the binding of common bone‐staining agents such as alizarin and its derivatives was confirmed in the new assay. This assay supports a strategy for targeted delivery of drugs to bone by attaching a bone‐affinity tag to the active drug substance.
Synthesis of 9,9‐Dialkyl‐4,5‐diazafluorene Derivatives and Their Structure–Activity Relationships Toward Human Carcinoma Cell Lines
Authors: Wang Qiwei , Yuen Marcus Chun‐Wah , Lu Guo‐Liang , Ho Cheuk‐Lam , Zhou Gui‐Jiang , Keung Oi‐Mei , Lam Kim‐Hung , Gambari Roberto , Tao Xiao‐Ming , Wong Raymond Siu‐Ming , Tong See‐Wai , Chan Kit‐Wah , Lau Fung‐Yi , Cheung Filly , Cheng Gregory Yin‐Ming , Chui Chung‐Hin , Wong Wai‐Yeung
Published: March 2010

A homologous set of 9,9‐dialkyl‐4,5‐diazafluorene compounds were prepared by alkylation of 4,5‐diazafluorene with the appropriate alkyl bromide and under basic conditions. The structures of these simple organic compounds were confirmed by spectroscopic techniques (FTIR, NMR, and FABMS). Their biological effects toward a panel of human carcinoma cells, including Hep3B hepatocellular carcinoma, MDAMB‐231 breast carcinoma, and SKHep‐1 hepatoma cells, were investigated; a structure–activity correlation was established with respect to the length of the alkyl chain and the fluorene ring structure. The relationship between the mean potency [log(1/IC50)] and alkyl chain length was systematically studied. The results show that compounds with butyl, hexyl, and octyl chains exhibit good growth inhibitory effects toward these three human carcinoma cell lines, and the 9,9‐dihexyl‐4,5‐diazafluorene further exhibits antitumor activity in athymic nude mice Hep3B xenograft models. For the structurally related dialkylfluorenes that lack the diaza functionality, in vitro cytotoxicity was not observed at clinically relevant concentrations.
Characteristics of pericardial effusions in patients with leukemia
Authors: Sampat Keeran , Rossi Adriana , Garcia‐Gutierrez Valentin , Cortes Jorge , Pierce Sherry , Kantarjian Hagop , Garcia‐Manero Guillermo
Published: March 2010

BACKGROUND:

Little information exists regarding the prevalence and natural history of pericardial disease in patients with leukemia. Recently, it has been reported that the use of histone deacetylase inhibitors is associated with an increased incidence of pericardial effusions (PEs). To study the characteristics and treatment relationships of PEs in patients with leukemia, the authors retrospectively analyzed a cohort of patients with leukemia evaluated at a single center.

METHODS:

The authors reviewed 2592 patients with acute myeloid leukemia (AML, n = 1282, 49%), acute lymphocytic leukemia (ALL, n = 336, 13%), or myelodysplastic syndrome (MDS, n = 974, 38%), who were evaluated from August 2003 to July 2008. Electronic medical records were reviewed to select patients who had undergone at least 1 echocardiographic evaluation. Data regarding diagnosis, timing, effusion size, survival, and prior therapy were collected for the patients who had echocardiographic evidence of PEs.

RESULTS:

PEs were detected in 325 (20%) of the patients who had echocardiograms: 21% in AML, 23% in ALL, and 18% in MDS patients. Only a small portion of PEs were detected before the initiation of therapy: 26% in AML, 25% ALL, and 15% in MDS patients. Most PEs were of minimal size (70%) overall. No significant differences in effusion characteristics, including severity, were observed among different types of therapies. The presence of PEs had no impact on the survival of the patients evaluated.

CONCLUSIONS:

PEs are relatively common in patients with leukemia and do not appear to be related to specific types of therapy or to survival. Cancer 2010. © 2010 American Cancer Society.
Phase 2 trial of pemetrexed disodium and carboplatin in previously untreated extensive‐stage small cell lung cancer, N0423
Authors: Chee Cheng E. , Jett James R. , Bernath Albert M. , Foster Nathan R. , Nelson Garth D. , Molina Julian , Nikcevich Daniel A. , Steen Preston D. , Flynn Patrick J. , Rowland Kendrith M.
Published: March 2010

BACKGROUND:

In extensive‐stage small cell lung cancer (SCLC), the combination of pemetrexed plus carboplatin has shown activity and appeared to be well‐tolerated. We conducted a trial to confirm the efficacy and to assess the tolerability of this chemotherapy combination.

METHODS:

Patients with untreated extensive‐stage SCLC were enrolled in this phase 2 open‐labeled study. They receive pemetrexed 500 mg/m2 and carboplatin (area under the curve of 5) every 21 days for a maximum 6 cycles. The primary endpoint for this trial was the confirmed response rate and the accrual goal was 70 patients.

RESULTS:

Forty‐six eligible patients (29 aged <70 years, 17 aged ≥70 years) were accrued to this study. The efficacy outcomes were similar between the 2 age groups. Overall, the confirmed response rate was 35% (16 of 46; 95% confidence interval [CI], 21%‐50%), where all 16 were partial responses. On the basis of these results, we had strong evidence that the study would not meet the preset efficacy criteria and was, therefore, closed before full accrual. The median duration of response was 4.4 months (95% CI, 2.9‐5.2). Median overall survival for patients aged <70 years and aged ≥70 years was 9.2 months (95% CI, 5.4‐11.6) and 10.8 months (95% CI, 2.2‐14.3), respectively. Grade 3 or higher toxicity rates were similar between the younger and older patients. Grade 3/4 and grade 4 hematological toxicities were observed in 46% and 26% of patients, respectively.

CONCLUSIONS:

Although well‐tolerated, the combination of pemetrexed and carboplatin is not as effective as standard therapy in patients with untreated extensive‐stage SCLC. Cancer 2010. © 2010 American Cancer Society.
Radiosurgical decompression of metastatic epidural compression
Authors: Ryu Samuel , Rock Jack , Jain Rajan , Lu Mei , Anderson Joseph , Jin Jian‐Yue , Rosenblum Mark , Movsas Benjamin , Kim Jae Ho
Published: March 2010

BACKGROUND:

Surgical decompression of metastatic epidural compression (MEC) improved ambulatory function. Spine radiosurgery can accurately target the epidural tumor and deliver high radiation doses for tumor control. Therefore, a clinical trial was performed to quantitatively determine the degree of epidural decompression by radiosurgery of metastatic epidural compression.

METHODS:

Sixty‐two patients with a total of 85 lesions of metastatic epidural compression were treated. Epidural compression was diagnosed by magnetic resonance imaging (MRI) scans. Main criteria of inclusion were neurological status with muscle power 4 of 5 or better. Radiosurgery was performed to the involved spine segment, including the epidural mass with median dose of 16 Gy (range 12‐20 Gy) in a single session. All patients had prospective clinical follow‐up, ranging from 1‐48 months (median 11.5 months), and 36 patients had pretreatment and post‐treatment imaging, ranging from 2‐33 months (median 9.3 months). Primary endpoints were epidural tumor control and thecal sac decompression.

RESULTS:

The mean epidural tumor volume reduction was 65 ± 14% at 2 months after radiosurgery. The epidural tumor area at the level of the most severe spinal cord compression was 0.82 ± 0.08 cm2 before radiosurgery and 0.41 ± 0.06 cm2 after radiosurgery (P < .001). Thecal sac patency improved from 55 ± 4% to 76 ± 3% (P < .001). Overall, neurological function improved in 81%.

CONCLUSIONS:

This study demonstrated a radiosurgical decompression of epidural tumor. Although neurosurgical decompression and radiotherapy is the standard treatment in patients with good performance, radiosurgical decompression can be a viable noninvasive treatment option for malignant epidural compression. Cancer 2010. © 2010 American Cancer Society.
Oxaliplatin and capecitabine in the treatment of patients with recurrent or refractory carcinoma of unknown primary site
Authors: Hainsworth John D. , Spigel David R. , Burris Howard A. , Shipley Dianna , Farley Cindy , Macias‐Perez Ines M. , Barton John , Greco F. Anthony
Published: March 2010

BACKGROUND:

Despite the widespread use of oxaliplatin‐based regimens for colorectal and other gastrointestinal cancers, there is surprisingly little information regarding their empiric use for the treatment of carcinoma of unknown primary site (CUP). In the current study, the combination of oxaliplatin and capecitabine in patients with recurrent and refractory CUP was examined.

METHODS:

Patients with CUP who had received at least 1 previous chemotherapy regimen were treated with oxaliplatin (130 mg/m2 intravenously on Day 1) and capecitabine (1000 mg/m2 orally twice daily on Days 1‐14). Treatment cycles were repeated every 21 days. Patients with objective response or stable disease after 2 cycles continued treatment for 6 cycles or until disease progression.

RESULTS:

Nine of 48 patients (19%) had objective responses to treatment; an additional 22 patients had stable disease at the time of first re‒evaluation. After a median follow‐up of 17 months, the median progression‐free and overall survivals were 3.7 months and 9.7 months, respectively. This regimen was reasonably well tolerated by most patients.

CONCLUSIONS:

The combination of oxaliplatin and capecitabine was found to have activity as a salvage treatment for patients with CUP. This regimen should be considered in patients with clinical and pathologic features suggesting a primary site in the gastrointestinal tract. Further development of the regimen as a first‐line therapy, or with bevacizumab added, is indicated. Cancer 2010. © 2010 American Cancer Society.