bluuebunny/crossref_metadata_2025 huggingface dataset:
Study on Pharmacological Activities and Mechanisms of the Essential Oil of the Flowers of Hemerocallis citrina Baroni (EOFHCB) in the Treatment
of Anxiety Disorders by GC-MS, Network Pharmacology, and Molecular Docking
Authors: Lu Tao , Liu Ziyi , Zhao Huaxiang , Zhou Xuan , Wang Qiong , Jiao Xiaoning , Lu Zhen
Published: July 2024

Background:

Hemerocallis citrina Baroni (Huanghuacai), a plant of the genus Hemerocallis
in the family Asphodelaceae, is widely planted in China. Based on our survey results,
the chemical compounds in the essential oil of the flowers of Hemerocallis citrina Baroni
(EOFHCB) and relevant pharmacological activities have never been studied systematically.

Objective:

To preliminarily decipher the pharmacological activities and mechanisms of EOFHCB
in the treatment of anxiety disorders by GC-MS, Network Pharmacology, and Molecular docking.

Methods:

EOFHCB compositions were identified using GC-MS, and their targets were predicted
using Swiss Target Prediction databases. The targets of anxiety disorders were obtained by
GeneCards, DisGeNET, and OMIM databases. The STRING database was used to construct the
protein-protein interaction networks, and the DAVID database was used to carry out GO enrichment
and KEGG pathway enrichment analysis. The EOFHCB-components-targetspathways-
anxiety disorders network was constructed by Cytoscape software (Version 3.10.0).
Finally, the result was verified by molecular docking.

Results:

28 chemical components were identified by GC-MS, including 3-furanmethanol
(28.43%), 2-methyl-1-butanol (27.13%), nerolidol (10.62%), and so on, which correspond to 241
potential targets. Several 2440 biological processes, 187 cellular compositions, and 311 molecular
functions were enriched by GO enrichment analysis and 174 pathways by KEGG enrichment
analysis. The key targets are PTGS 2, SRC, DRD 2, ESR 1, MAOB, and SLC6A4. The most important
pathway is the neuroactive ligand-receptor interaction.

result:

28 chemical components were identified by GC-MS, including 3-Furanmethanol(28.43%), 2-methyl-1-Butanol(27.13%), Nerolidol (10.62%) and so on, which correspond to 241 potential targets. 2440 biological processes, 187 cellular composition and 311 molecular functions were enriched by GO enrichment analysis, and 174 pathways by KEGG enrichment analysis . The key targets are PTGS 2, SRC, DRD 2, ESR 1, MAOB, and SLC6A4. The most important pathway is the neuroactive ligand-receptor interaction.

Conclusion:

EOFHCB exerts its therapeutic effects on anxiety disorders through multicomponents,
multi-targets, and multi-pathways, which provided new ideas and methods for the
in-depth research of aromatic Chinese medicine in the treatment of anxiety disorders.
Unveiling the Significance of MRP 1 in Achieving Complete
Remission Following Induction Therapy in Acute Myeloid
Leukemia
Authors: Kamil Saba , Kouser Shaheen , Naeem Nadia , Farroqui Waqas , Sharafat Shaheen , Khan Farrukh Ali , Haider Ghulam , Kamil Noor , Ali Raahim , Abbass Farah Fatima , Khan Nehad , Khan Ramsha
Published: July 2024

Background:

Increased expression of MRP 1 in AML patients results in the
efflux of drugs from the cells, preventing the patient from achieving remission or
potentially leading to relapse. Several studies have demonstrated that early
identification of ABC transporter may yield favorable outcomes.

Aims and objectives:

The objectives of the study were to investigate the correlation
between MRP 1 gene expression and MRP 1 protein levels and the response to
remission induction in AML patients.

Method:

A total of 40 AML patients were recruited from March 2021 to June 2022.
Peripheral blood was collected in two tubes (yellow and purple top) to assess the MRP
1 gene and protein. For MRP 1 gene assessment, RNA was isolated from blood
samples, cDNA was prepared, and qRT-PCR was performed to analyze gene
expression. The relationship between the gene and complete remission was
determined. Identification of MRP 1 protein was conducted using ELISA, and the
relationship between protein levels and complete remission (CR) was explored.

Results:

Most of the patients were aged between 25 and 39 years, encompassing
both males and females. This study observed a clinical correlation between MRP 1
gene expression and complete remission. The findings revealed that 69.2 percent of
patients with high gene expression failed to achieve complete remission, whereas the
analysis of MRP 1 protein in relation to complete remission showed no statistical
significance. The MRP1 gene showed high expression (66.7%) in patients with FLT3
mutation, whereas low expression of MRP1 was associated with a high occurrence
(60%) of NMP1 mutation.

Conclusion:

Further comprehensive multicenter studies with larger sample sizes are
required to validate the findings of this study. It is recommended to pinpoint the
mechanism and regulation of MRP 1 and its interaction with other molecular pathways
Synthesis of Some New Chiral Triazole-oxazoline Derivatives
Authors: Dong Hong-Ru
Published: July 2024

:

Some new (S)-2-[1-aryl-5-methyl-1H-1,2,3-triazol-4-yl]-4-benzyl-4,5-dihydro-ox-azoline were synthesized by the reaction of (S)-N-(1-hydroxy-3-phenylpropan-2-yl)-1-aryl-5-methyl-1H-1,2,3-triazole-4-carboxamides which were prepared from aromatic amine as start-ing materials, with p-toluenesulfonyl chloride, triethylamine and DMAP. The structures were characterized by 1H NMR, 13C NMR, MS and IR. The synthesized chiral triazole-oxazoline was used as a ligand in the Diels-Alder asymmetric catalytic reaction between 3-allyl-1,3-ox-azolidin-2-ketone and 2-methyl-1,3-butadiene, using PdCl2 as catalyst. (S)-3-(4-methylcyclo-hexe-3-ene-1-formyl)-1,3-oxazolidin-2-one was obtained.

Background:

The chiral triazole-oxazoline ligands are rarely reported.

Objective:

The aim of the study was to synthsize some new chiral triazole-oxazoline ligands (S)-4-benzyl-2-(1-aryl-5-methyl-1H-1,2,3-triazole-4-yl)-4,5-dihydrooxazoline (5a-g).

Methods:

The one-pot methods of oriented synthesis were adopted. This study provides a sim-ple and effective method for the synthesis of new chiral triazole-oxazoline derivatives.

Results:

The some new chiral the triazole-oxazoline ligands (S)-4-benzyl-2-(1-aryl-5-methyl-1H-1,2,3-triazole-4-yl)-4,5-dihydrooxazoline (5a-g) were synthesized and the asymmetric Diels-Alder cyclization of 3-allyl-1,3-oxazolidin-2-ketone and 2-methyl-1,3-butadiene was catalyzed by PdCl2 using the synthesized (S)-4-triazole-oxazoline ligands.

Conclusion:

Some new (S)-4-benzyl-2-(1-aryl-5-methyl-1H-1,2,3-triazole-4-yl)-4,5-dihydro-oxazoline was synthesized by corresponding N-[(S)-1-hydroxy-3-phenylpropan-2-yl]-1-aryl-5-methyl-1H-1,2,3-triazole-4-formamide, through one-pot oriented synthesis method. After preliminary evaluation, the chiral triazoline-oxazoline ligands, in which 1,2,3-triazole rings, like pyridine-type rings, chiral materials were saved and replace one oxazoline ring in the di-oxazoline ligands for asymmetric catalytic reactions.
Chromatography Chronicles: Unveiling the Power of Reversed-phase
High-performance Thin Layer Chromatography in Pharmaceutical
Analysis
Authors: Pandya Hetvi , Devaliya Dev , Shah Akshi , Kotadiya Rajendra
Published: July 2024

Pharmaceutical analysis is critical in ensuring the quality and safety of drug substances
and formulations. High-performance thin-layer Chromatography (HPTLC) has emerged as a powerful analytical technique in the pharmaceutical industry due to its numerous advantages, including
high separation efficiency, cost-effectiveness, and ease of sample preparation. One of its variants,
Reversed-Phase High-Performance Thin-Layer Chromatography (RP-HPTLC), has gained immense
popularity for analyzing nonpolar and slightly polar compounds, including drugs and their metabolites. This review paper draws attention to history and the recent developments in RP-HPTLC for
pharmaceutical analysis. It highlights the advantages and limitations of RP-HPTLC, discussing its
applications in drug analysis, impurity determination, stability-indicating assays, and more. In this
study, recent advances in RP-HPTLC instrumentation and techniques were reviewed, including hyphenated methods, such as Reversed-Phase High-Performance Thin-Layer Chromatography coupled
with Mass Spectrometry and Reversed-Phase High-Performance Thin-Layer Chromatography coupled with Nuclear Magnetic Resonance. Through this comprehensive analysis, the authors aim to
underscore the potential of RP-HPTLC as a reliable and efficient analytical technique in the pharmaceutical industry and shed light on future trends in this field.
Withdrawn: Fumarate-1 Mediates the Regulation of Mitochondrial Homeostasis by PGC-1α to Promote Cell Pyroptosis and Inhibit the Thyroid Cancer
Authors: Meng Xiaomei , You Dong , Ren Ruizhen
Published: July 2024

Since the authors are not responding to the editor’s requests to fulfill the editorial requirement, therefore, the article has been
withdrawn.
Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php.

BENTHAM SCIENCE DISCLAIMER:

It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously
submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere
must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting
the article for publication the authors agree that the publishers have the legal right to take appropriate action against the
authors, if plagiarism or fabricated information is discovered. By submitting a manuscript the authors agree that the copyright
of their article is transferred to the publishers if and when the article is accepted for publication.
Anti-cancer Activity Evaluation of Naphthalenonic and Chromanonic Spiroisoxazoline Derivatives as Selective COX-2 Inhibitors on HT29 Cell Lines
Authors: Kalhor Hourieh , Movahhed Tahereh Komeili , Mousavi Shokoufeh , Qomi Masoumeh Sadri , Abolhasani Ahmad , Mirani Masoumeh , Rad Minoo Hosseini , Heidari Fatemeh , Abolhasani Hoda
Published: July 2024

Background:

Cyclooxygenase-2 (COX-2) is induced in response to proinflammatory
conditions, and it is not only a key enzyme in the inflammatory process, but also seems to be
highly expressed in various types of cancer cells. On the other hand, it is well documented that
chemical compounds with spiro scaffolds in their structure could be effective chemical agents
against cancer types.

Objective:

In this study, the cytotoxicity effects of spiroisoxazoline derivatives containing naphthalinone and chromanone spiro-bridge were investigated.

Methods:

The cytotoxicity effects of compounds 7a-7h were evaluated by performing the MTT
assay on the HT-29 (colorectal cancer), MCF-7 (breast cancer), and HEK-293 (normal kidney)
cell lines. After that, a compound with high yield and remarkable cytotoxic activity was selected
to analyze the cell cycle and apoptosis mechanism.

Results:

The most effective cytotoxic activity was observed on HT-29 and MCF-7 cell lines of
compounds 7b (IC50 value: 1.07±0.28 µM) and 7f (IC50 value: 11.92±1.07 µM). None of the
compounds had a toxic effect on normal HEK-293 cells, except for compound 7g with an IC50
value of 21.30±16.14 µM, whose effect was much lower than that of cisplatin and doxorubicin,
known as anti-cancer agents. Subsequently, compound 7e with significant yield and cytotoxic
activity was investigated to evaluate cell cycle and apoptosis. The result showed that compound
7e induced significant G0/G1 cell cycle arrest and apoptosis in HT-29 cells

Conclusion:

The selective COX-2 inhibitor compounds with spiroisoxazoline core structure
could be suitable scaffolds for cytotoxic effects.
COVID-19 and Digestive Diseases: A Comprehensive Review on
Pathophysiology and Clinical Management
Authors: Ibrahim Noha E. , Mohamed Hassan Fatma
Published: July 2024

A serious pandemic has been presented by the Severe Acute Respiratory Syndrome Coronavirus
2 (SARS-CoV-2), a coronavirus that causes the severe acute respiratory infection known
as Coronavirus disease 2019 (COVID-19). It has become a major health hazard that affects people all
around the world. Although the respiratory symptoms are the main manifestations of COVID-19,
several extrapulmonary manifestations have been observed, including cardiovascular, renal, and
gastrointestinal symptoms. The digestive system may be an additional or non-traditional pathway for
COVID-19 to spread and manifest as Angiotensin-Converting Enzyme 2 (ACE2), the entry point of
SARS-CoV-2 into the cells is present in the gastrointestinal tract and liver. Gastrointestinal symptoms,
such as vomiting, anorexia, nausea, and diarrhea, are infrequent in COVID-19 patients; however,
some of these symptoms may manifest independently of other respiratory symptoms. Also,
SARS-CoV-2 virus can cause liver and pancreatic damage. Studying the pathogenic mechanisms of
COVID-19 in the digestive system could aid in improving patient diagnosis and treatment. The review
aims to provide an overview of the mechanisms, symptoms, and management of SARS-CoV-
2's effects on the digestive system. Hence, medical professionals would be aware of the digestive
symptoms associated with COVID-19 and would promptly alter treatment regimens for patients exhibiting
abnormal hepatic and gastrointestinal manifestations.
Regression model for a drug-related crime reduction
Authors:   College of Criminology, Nueva Ecija University of Science and Technology, Cabanatuan, Philippines, Aydinan Januaryn Jose B.
Published: July 2024

Globally, drug-related offenses present a significant challenge, necessitating the development of effective prevention strategies. This abstract describes a regression model designed to address the complex dynamics of drug-related crimes. Using data from parents, faculty, and youth at a university, including demographic profiles and other drug-related information, the model identifies key factors contributing to the potential prevention of drug-related crimes. Through regression analysis, the model quantifies the relationships between these variables and provides insights into the causes of drug-related criminal behavior based on respondents' observations. The model identifies the most influential predictors of reducing drug-related crimes through careful preprocessing and feature selection, enabling a targeted approach to crime prevention and intervention strategies. The results show that each approach within the drug prevention model is significant. Notably, the findings indicate that parental involvement has the greatest impact on reducing drug criminality. Teachers contribute by focusing on the effects of drugs through seminars and integrating this information into their subjects. The community can also promote sports-related activities to divert youth interest. It is anticipated that these efforts will be effective because parents are already actively advising and educating their children.
Informe bibliométrico (2019-2023): Revista Ciencia y Tecnología Agropecuaria
Authors: Corchuelo Rodriguez Camilo Alejandro , Villa Jiménez Claudia Pilar
Published: July 2024

La revista Ciencia y Tecnología Agropecuaria (C&TA) se concibe como una publicación de acceso abierto diamante, editada y financiada por la Corporación Colombiana de Investigación Agropecuaria (Agrosavia) desde el año de 1996. Durante los más de 28 años de existencia ha tenido dos estudios cienciométricos de sus contenidos, el primero en 2020 donde se analizaron los artículos publicados en medicina veterinaria y zootecnia (González & Salgado-Arroyo, 2020), el segundo en 2024 donde se aborda la trayectoria de la revista en la construcción de nuevo conocimiento para el sector agropecuario colombiano y de la región (Flórez-Martínez, 2024). No obstante, el presente estudio estudio cienciométrico tiene por objetivo ver analizar en el periodo de 2019 al 2023 el comportamiento de la revista en las principales sistemas de indexación y resumen a nivel mundial (Google Scholar (GS), Scopus y WOS) (Martín-Martín et al., 2021; Thelwall & Kousha, 2015; Yang & Meho, 2006). Además, se realizó un análisis una vigilancia científica de las líneas temáticas de la revista con el fin de identificar comportamientos, autores, organizaciones y tendencias para contar con herramientas que permitan fortalecer el posicionamiento y visibilidad de la revista a nivel regional y mundial.
AI in Psoriatic Disease: Scoping Review
Authors: Barlow Richard , Bewley Anthony , Gkini Maria Angeliki
Published: July 2024

Background

Artificial intelligence (AI) has many applications in numerous medical fields, including dermatology. Although the majority of AI studies in dermatology focus on skin cancer, there is growing interest in the applicability of AI models in inflammatory diseases, such as psoriasis. Psoriatic disease is a chronic, inflammatory, immune-mediated systemic condition with multiple comorbidities and a significant impact on patients’ quality of life. Advanced treatments, including biologics and small molecules, have transformed the management of psoriatic disease. Nevertheless, there are still considerable unmet needs. Globally, delays in the diagnosis of the disease and its severity are common due to poor access to health care systems. Moreover, despite the abundance of treatments, we are unable to predict which is the right medication for the right patient, especially in resource-limited settings. AI could be an additional tool to address those needs. In this way, we can improve rates of diagnosis, accurately assess severity, and predict outcomes of treatment.

Objective

This study aims to provide an up-to-date literature review on the use of AI in psoriatic disease, including diagnostics and clinical management as well as addressing the limitations in applicability.

Methods

We searched the databases MEDLINE, PubMed, and Embase using the keywords “AI AND psoriasis OR psoriatic arthritis OR psoriatic disease,” “machine learning AND psoriasis OR psoriatic arthritis OR psoriatic disease,” and “prognostic model AND psoriasis OR psoriatic arthritis OR psoriatic disease” until June 1, 2023. Reference lists of relevant papers were also cross-examined for other papers not detected in the initial search.

Results

Our literature search yielded 38 relevant papers. AI has been identified as a key component in digital health technologies. Within this field, there is the potential to apply specific techniques such as machine learning and deep learning to address several aspects of managing psoriatic disease. This includes diagnosis, particularly useful for remote teledermatology via photographs taken by patients as well as monitoring and estimating severity. Similarly, AI can be used to synthesize the vast data sets already in place through patient registries which can help identify appropriate biologic treatments for future cohorts and those individuals most likely to develop complications.

Conclusions

There are multiple advantageous uses for AI and digital health technologies in psoriatic disease. With wider implementation of AI, we need to be mindful of potential limitations, such as validation and standardization or generalizability of results in specific populations, such as patients with darker skin phototypes.
Subjective Cognitive Concerns are Associated with Worse Performance on Mobile-App Based Cognitive Assessment: An Observational Study in Cognitively Normal Older Adults (Preprint)
Authors: Nester Caroline O. , De Vito Alyssa N. , Prieto Sarah , Kunicki Zachary J. , Strenger Jennifer , Harrington Karra D. , Roque Nelson , Sliwinski Martin J. , Rabin Laura A. , Thompson Louisa I.
Published: July 2024

BACKGROUND

Subjective cognitive concerns (SCC) may be among the earliest clinical symptoms of dementia. There is growing interest in applying mobile app-based cognitive assessment to remotely screen for cognitive status in preclinical dementia, but the relationship between SCC and relevant mobile assessment metrics is uncertain.

OBJECTIVE

We characterized the relationship between SCC and adherence, satisfaction, and performance on mobile-app assessments in cognitively unimpaired older adults.

METHODS

Participants (N=122, Mage=69.85, Meducation=16.52, %female=66.7, %White=86.2) completed 8 assessment days using Mobile Monitoring of Cognitive Change (M2C2), an app-based testing platform, with brief daily sessions within morning, afternoon, and evening time windows (24 total testing sessions). M2C2 includes digital working memory, processing speed, and episodic memory tasks. Participants provided feedback about their satisfaction and motivation related to M2C2 upon study completion. SCC was assessed using the Cognitive Function Instrument (CFI). Regression analyses evaluated the association between SCC and adherence, satisfaction, and performance on M2C2, controlling for age, sex, and loneliness (UCLA Loneliness Scale). Linear-mixed effects models evaluated whether SCC predicted M2C2 subtest performance over the 8-day testing period, controlling for covariates.

RESULTS

SCC was not associated with app satisfaction or protocol motivation, but it was significantly associated with lower rates of protocol adherence (ß=-0.19, p=.04, 95% CI -0.642, -0.016). Higher SCC endorsement significantly predicted worse overall episodic memory performance (ß=-0.201, p = .021, 95% CI -0.02, -0.01), but not working memory or processing speed. There was a main effect of SCC on working memory performance at day 1 (Est=-1.017, SE=0.49, p=0.038) and a significant interaction between SCC and working memory over the 8-day period (Est=0.047, SE=0.02, p=0.039), such that SCC was associated with initially worse, then progressively better working memory performance.

CONCLUSIONS

SCCs are associated with worse overall memory performance on mobile-app assessments, patterns of cognitive inefficiency (variable working memory) and mildly diminished adherence across an 8-day assessment period. Findings suggest that mobile app assessments may be sensitive to subtle cognitive changes, with important implications for early detection and treatment for individuals at risk for dementia.
Research on the Joint Evaluation of Geological Disaster Susceptibility Based on Fractal Theory and Hierarchical Analysis Method
Authors: Huang Ying
Published: July 2024

In recent years, strong earthquakes and extreme climate events occur frequently in southwest China, forming a large number of mass geological disasters, which seriously threaten the life and property safety of local people. Therefore, so it is particularly important to carry out the refined evaluation of regional geological disaster susceptibility. On the basis of summarizing the previous research results, in the mountain area of mianzhu, Sichuan province, selected elevation, undulation, slope, stratum, fault, drainage, highway, based on the fractal theory (FT) joint level analysis (AHP) evaluation model, realize the study area fine geological disaster prone evaluation, make up for the traditional method in terms of weight determination and calculation accuracy. The evaluation results show that the extremely high prone area and the high prone area are basically concentrated in the low fluctuation area, low slope area, dense water system area and fault concentration area, with an area of 90.38km2 (13.63%). The AUC value of the combined model was 0.865, indicating that the evaluation results have high accuracy and reliability, which can provide necessary support for the geological disaster prevention and control work in Mianzhu city, and can also provide reference for the evaluation of geological disaster susceptibility in similar areas.
Research on the Development of Integrated Educational Literacy among Students Majoring in Early Childhood Education
Authors: Chao Qiuhong , Hong JiMyeong
Published: July 2024

In recent years, China has implemented various policies to strengthen the development of inclusive education in early childhood education, particularly focusing on improving the pre-service training quality of teachers in this field. Therefore, this study aims to explore the current state of inclusive education literacy among early childhood education majors. The research subjects are 13 soon-to-graduate students majoring in early childhood education from higher education institutions in Guangdong Province. The study uses a case interview method and employs Nvivo14 software for coding analysis of the textual data. The results indicate that while early childhood education majors generally recognize the concept of inclusive education, they lack a deep understanding of it. They acknowledge the importance of inclusive education courses but have a relatively limited experience with its forms. Additionally, internship experiences with special needs children influence their self-efficacy in inclusive education to a certain extent.
REVOLUTIONIZING DRUG DISCOVERY: UTILIZING BIOMARKERS FOR PRECISION MEDICINE AND TARGETED THERAPIES
Authors: NAIR RHEA VINOD , S KRUPA
Published: July 2024

Drug discovery remains a complex and time-consuming process, often hindered by inefficiencies and high failure rates. Biomarkers, measurable indicators of biological processes, have emerged as powerful tools to revolutionize this landscape. This article explores the multifaceted role of biomarkers throughout the drug discovery, from target identification and drug development to clinical trials and patient stratification. We highlight how biomarkers enhance our understanding of disease mechanisms, facilitate the selection of promising drug candidates, and enable objective assessment of drug efficacy and safety. Furthermore, the integration of biomarkers with companion diagnostics allows for personalized medicine approaches, tailoring treatment options to individual patient needs. We discuss the various types of biomarkers employed in drug discovery, including genomic, proteomic, and imaging biomarkers, while acknowledging the challenges associated with their validation and regulatory approval. In conclusion, the strategic utilization of biomarkers holds immense potential to streamline drug discovery, accelerate development timelines, and ultimately bring safer and more effective therapies to patients.
EUROPEAN SOCIO-POLITICAL ELITES’ ATTITUDES TOWARDS MIGRATION
Authors: Gligorić Miroslava
Published: July 2024

This paper analyses the attitudes of European socio-political elites towards migration, with a particular focus on their views on current migration movements that are partly common and partly divergent, depending on the interests that guide them and their societies. Regarding the attitudes of socio-political elites towards the migrant issue, it is observed that the creators of European policies mainly advocate for the ‘externalisation’ of control over the migration issue, primarily involving the relocation of migrant rights outside the EU borders and disregarding their human rights. There is also a noticeable trend of informal deviation from the principles of human rights and freedoms associated with the migration problem, approaching the perspectives of the so-called Visegrád Group, while fundamentally remaining on liberal positions in this domain. The subject of this paper is the relationship between European socio-political elites and current migrations, and the methods applied in the paper include scientific-descriptive, comparative, and content analysis. The aim of the paper is to analyse the most dominant attitudes and indicate the consequences of specific decisions made by individual European socio-political elites regarding migration.
In-Vitro Management of Erwinia amylovora caused by Fire Blight of Apple with Synthetic Chemicals
Authors: Ullah Niamat , Ahmed Basheer , Waris Muhammad , Baloch Adnan , Yousuf Sarfraz
Published: July 2024

Apple (Malus pomila L) belongs to family Rosacea and it is an edible fruit; mostly utilized by different age groups. Apple trees are grown worldwide. It is considered an important fruit in the temperate region of Balochistan, Pakistan. Fire blight is caused by the pathogen Erwinia amylovora the most damaging disease of apple and other pomes orchards in the world. The aim of the present study was conducted to record the incidence of the disease and management through the use of chemicals. For this purpose, survey was conducted for disease samples from the various districts of Balochistan Viz., Quetta, Ziarat, Killa Saifullah and Kalat. Among all the districts Ziarat was found to be most severe by pathogen with 20% incidence followed by Quetta having 18.67%, Kalat14.31% and Killa Saifullah 13.44% incidence, and different chemicals, i.e. Streptomycin, Tetracycline, Gentamicin, Kasugomycin, Oxytetracycline at different doses were tested against the pathogen and all the chemicals shown great effectiveness against Erwiana amylorora In-vitro conditions. The maximum inhibition zone made by chemical streptomycin with value 15.50 and minimum value of tetracycline with 10.90.and there was no inhibition zone observed in control treatment. All the data was statistically analyzed
A Conceptual Analytic Study of Sex Determination or Ling Nirdharana in Ayurveda
Authors: Rohila Dr. Saurabh Chandra
Published: July 2024

Abstract: All parents have long desired healthy, intelligent, and beautiful children, as reflected in concepts from classical texts like "Suputrakameeya." Ayurveda, an ancient Indian system of medicine, provides simple methods to ensure the birth of a healthy child, beginning with partner selection and addressing factors related to fetal development, including fertilization and sex determination. It emphasizes the roles of Shukra (sperm) and Shonita (ovum) in conception, with the dominance of Shonita leading to female offspring and Shukra to male offspring. Similarly, modern science determines sex by the presence of X and Y chromosomes, with the Y chromosome playing a crucial role in male development. Hormones such as Anti-Mullerian Hormone (AMH) and testosterone influence the development of reproductive organs and secondary sexual characteristics. Both Ayurveda and contemporary science provide valuable insights into the genetic and biological aspects of human development
A Study on the Factors Influencing Aging in Place of the Elderly by Subjective Physical Status
Authors: Shin In Jin , Kim Seung Hee ,   Residential Environment Institute Of Korea
Published: July 2024

Low birth rate and aging are rapidly changing the demographic of our society and pushing us entering into a super aged society. In the super-aged society where more than 20% of the total population is over 65 years old, the residence problem for elderly has become a growing social problem as life expectancy increases. This study used the '2020 Survey on the Elderly' and a multinomial logistic regression model to analyze factors affecting AIP (Aging in Place) attitudes among the elderly. As a result, first, AIP attitudes against 'moving to good housing' when healthy are seen when sample are older, single, live in their own home, and do not have a private or retirement pension. AIP attitude toward 'moving to a house with care and convenience services' appears in those who are unmarried, have a short period of education, live in monthly rentals, and receive housing pension and farmland pension. Next, AIP attitude against ‘living with children’ when having difficulty with mobility appears in male, single, living in own home, and not receiving a private or retirement pension. The AIP attitude against 'moving to welfare housing' appears in cases where the period of education is short, living in a self-owned house, receiving housing pension or farmland pension, and having many financial assets or low debt. The study highlights the importance of cash flow for elderly households. AIP attitudes are linked to private and public income. Securing regular income for retired seniors and improving cash flow policies is crucial for realizing AIP.
Analysis of Factors Determining Apartment Prices in Local Submarkets: Focusing on Corporate location and Brand Apartments
Authors: LEE Seung Hurn , SUH Jeong Yeal ,   Residential Environment Institute Of Korea
Published: July 2024

This study aims to identify the characteristics of apartment price determinants between two local submarkets, and to ascertain the price differential between branded and non-branded apartments and corporate location. Multi-Regression analysis was conducted on the total number of apartments transacted in Geoje City over the past four years, using the actual transaction price of apartments as the dependent variable and structure, complex, brand, and corporate location characteristics as independent variables.
The results indicate that in Suyang-dong(high prices), the variables of floor, floor area ratio, and brand have a positive effect, while the variables of rooms and corporate distance have a negative effect. In Okpo-dong(low prices), the number of car parking spaces and brand variables have a positive effect. Branded apartments are priced higher than non-branded apartments. Additionally, the value ratio of branded apartments is higher in the lower-priced area. Price discrepancies may exist within the same area, Consequently, branded apartments that cater to local characteristics can command high prices, even in price sub-areas.
A study on the characteristics of the lower grade classroom space in Green Smart Future School: Focusing on the cases where of Daegu City elementary school space innovation projects were completed starting in 2018
Authors: KIM Young-Ae , LEE Keun-Taek ,   Residential Environment Institute Of Korea
Published: July 2024

In July 2020, the Ministry of Education announced the 'Green Smart Future School' project plan as the representative task of the Korean version of the New Deal. The Green Smart Future School project is a project promoted in the form of 'smart classroom', 'green school', and 'connection with local communities' based on 'space innovation', and 'safety' was added in 'Green Smart Future School 2.0' in 2022. In this study, the characteristics of the changed classroom space were analyzed through the results of the spatial innovation project conducted by the Daegu City Office of Education. Based on these results, the direction of reorganization of classroom space for the lower grades of elementary school for Green Smart Future School was suggested. Therefore, this study is thought to be used as a guide for the creation of a green smart future school in the future.
The impact of “Introduction of Smart Store Technology” on sales and satisfaction of small business stores: Around customer communication
Authors: CHANG Chong-Ho , JANG Hee-Soon ,   Residential Environment Institute Of Korea
Published: July 2024

This study decomposes the local gap through the oaxaca factor analysis to find out how differences in housing prices affect the management costs with data the average value of three-year management costs between 2014 and 2016 to 536 complexes in three Gangnam and Gangbuk districts in Seoul. The results of the analysis of 290 complexes in three Gangnam and 246 complexes in three Gangbuk districts are as follows. First, housing prices did not affect administrative costs within the region, but were variables that affected data pooling. Second, when compared with the three Gangnam districts, the results of the characteristic coefficient, which can be explained by the characteristics of the complex and the external environment, showed that the gap in the management cost increased when the number of security personnel, repair and maintenance costs, elevator maintenance cost, floor area ratio, and 60m2 or more to 85m2. Third, the factors behind the gap between Gangnam 3 districts, which have higher housing prices than Gangbuk 3 districts, were confirmed to be the number of security personnel, repair costs, floor area ratio and elevator maintenance costs, and the higher the size and income of their holdings, the more they lived in Gangnam 3 districts, where local infrastructure was expanded, causing social inequality due to differences in housing welfare, such as safety, comfort and convenience.
A Study on Research on real estate transactions and information platform utilization: Focusing on immersion and trust based on convenience
Authors: CHOI In-Sub , KIM Jae-Tea ,   Residential Environment Institute Of Korea
Published: July 2024

The purpose of this study was to analyze how the benefits provided to users in the utilization of real estate transaction and information platforms affect user engagement and trust in the platform.
The analysis methods used in this study included basic statistical analysis, factor analysis, and structural equation modeling, utilizing SPSS 27.0 and AMOS 24.0 programs as analytical tools. In April 2024, a survey was conducted among men and women in their 20s to 50s residing in various regions, and 602 final valid samples were selected and analyzed.
The following research results have been derived: First, information acquisition benefits have a significant impact on trust.
Second, psychological benefits have a significant impact on trust.
Third, economic benefits have a significant impact on trust.
Fourth, customization benefits have impact on trust.
Finally, usage trust has a significant impact on immersion.
Through the above research, implications were presented on which benefits to enhance in order for users to stay longer and develop trust in the real estate platform.
INCREASING THE EFFICIENCY OF USING A POTATO DIGGER WITH AN AUTOMATIC SYSTEM IN VARIABLE SOIL CONDITIONS
Authors: HADZHIEV P.I. ,   Russian State University of National Economy named after V.I. Vernadsky, Balashikha, Russian Federation, MAHMUTOV M.M. , RAMAZANOVA G.G. , HADZHIEV I.P. ,   Russian State University of National Economy named after V.I. Vernadsky, Balashikha, Russian Federation,   Russian State University of National Economy named after V.I. Vernadsky, Balashikha, Russian Federation,   Russian State University of National Economy named after V.I. Vernadsky, Balashikha, Russian Federation
Published: July 2024

The article discusses the issues of reducing soil compaction when harvesting potatoes with an automatic system for regulating the internal tire pressure of the running wheels of a potato digger. As a result of the influence of the propulsors and the running system as a whole, a change in the soil structure occurs, not only in the rut itself, but also in the areas located next to it, which indicates the nature of the spread of soil deformation and its influence on the condition of soil covers, which ultimately leads to a decrease in yield. (Purpose of the study) Reducing soil compaction on waterlogged soils by automatically adjusting tire pressure depending on soil moisture. (Materials and methods) A potato digger with an automatic system for regulating the tire pressure of running wheels has been developed. (Results and discussion) The reduction in soil compaction occurs due to the fact that it is additionally equipped with a capacitive sensor for measuring soil moisture, made in the form of a wheel, where, with reduced humidity, a signal is sent from the capacitive sensor to the automatic pressure control system to increase the tire pressure in the running wheels. from the air supply tube under pressure, air enters the chamber of the running wheels of the potato digger; at high humidity, a signal is sent from the capacitive sensor to the automatic pressure control system to reduce the internal tire pressure in the running wheels; the air leaves the wheel tires of the running system of the potato digger through the outlet into the environment and reduces tire pressure. (Conclusions) As a result of automatic tire pressure changes, the density of the soil in the wheel track is significantly reduced, thereby preventing soil compaction.
DETERMINATION OF SPROUTED GRAIN’S PHYSICAL-AND-MECHANICAL PROPERTIES
Authors: SAENKO YU.V. ,   Белгородский государственный аграрный университет им. В.Я. Горина, BAYRAMOV R.Z. ,   Белгородский государственный аграрный университет им. В.Я. Горина
Published: July 2024

One of the most common types of raw feed in farming is grain. It is used as the main component in combined feeds. Sprouted grain is a feed additive natural that vitamins containing. It is known that stronger animals food first eating. In order for the sprouted grain had reached the livestock entire proportion for feed consumption, the first evenly in the feed must be distributed. To do this, the sprouted grain must be dried, crushed, and then mixed with combined feed. The sprouts and sprouted grain’s strength properties differ from ordinary (non sprouted) grain, therefore, at crushing them in conventional hammer crushers, the energy intensity process will increase. To reduce the sprouted grain grinding’s energy consumption, it is necessary that cause destruction’s loads knowing. It is known that the grain by crushing is crushed, and the sprout is cut. To design the grinding machines’ working bodies, it is necessary the grain and sprouted grain’s germ strength properties knowing. At sprouted grain preparing, it is moving along the processing line and pouring itself repeatedly. To avoid sprouted grain’s on the gravity flows’ surface sticking, it is necessary the static friction coefficients taking into account. The stands for loads’ determination causing the grains and germinated grain sprouts’ destruction are presented. On one stand, due to the applied effort, the grain is split by a rod using, and by the rod with a knife replacing the sprout is cut. During the experiments, the force is recorded. On another stand, the static friction coefficients of sprouted and unsprouted grain on galvanized steel, plastic, rubber, plywood surfaces are determined. The experimental studies’ results are presented. It has been established that the Young modul’s of sprouted grain average value is lesser than for unsprouted one. The unsprouted wheat had the lowest the friction coefficient value on plywood, it’s 0.31...0.33, on rubber this coefficient took the highest value - 0.4...0.47.
Rentabilidad de empresas constructoras en Chile ¿Cómo afecta el capital de trabajo y su apalancamiento financiero?
Authors: Sepúlveda Mellado Danilo Bernabé , Zegpi Delgado Diabb , Benites Gutiérrez Luis Alberto , Mendoza Orbegoso Elder Marino
Published: July 2024

El presente trabajo de investigación se centró en modelar el desempeño financiero de empresas constructoras chilenas mediante regresiones lineales de efectos fijos y mixtos, utilizando el margen bruto trimestral como indicador de rentabilidad. Entre los modelos evaluados, se determinó que el modelo de efectos mixtos con efectos aleatorios por empresa mostró el mejor ajuste al conjunto de datos, con un coeficiente de determinación estimado (R2) de 0,92, siendo significativos variables como el CT, el CT cuadrático y la tasa de endeudamiento a corto plazo. La combinación de efectos del CT cuadrático y no cuadrático indicó que el impacto positivo del CT en el margen se hace evidente a partir de una tasa del 42% sobre los activos totales.
Quantum-embeddable stochastic matrices
Authors: Shahbeigi Fereshte , Chubb Christopher T. , Kukulski Ryszard , Pawela Łukasz , Korzekwa Kamil
Published: July 2024

The classical embeddability problem asks whether a given stochastic matrix T, describing transition probabilities of a d-level system, can arise from the underlying homogeneous continuous-time Markov process. Here, we investigate the quantum version of this problem, asking of the existence of a Markovian quantum channel generating state transitions described by a given T. More precisely, we aim at characterising the set of quantum-embeddable stochastic matrices that arise from memoryless continuous-time quantum evolution. To this end, we derive both upper and lower bounds on that set, providing new families of stochastic matrices that are quantum-embeddable but not classically-embeddable, as well as families of stochastic matrices that are not quantum-embeddable. As a result, we demonstrate that a larger set of transition matrices can be explained by memoryless models if the dynamics is allowed to be quantum, but we also identify a non-zero measure set of random processes that cannot be explained by either classical or quantum memoryless dynamics. Finally, we fully characterise extreme stochastic matrices (with entries given only by zeros and ones) that are quantum-embeddable.
Неоклассицизм в русской архитектуре XXI века
Authors: Копылова Лариса
Published: July 2024

Статья посвящена третьей волне русского неоклассицизма, охватывающей период с 1990-х по 2020-е годы, крупные реализованные проекты которого приходятся на XXI век. Цель статьи – теоретически осмыслить направление, определить генезис, этапы эволюции и формальную концепцию стиля; уточнить круг архитекторов и основных построек; провести сравнение с двумя предшествующими волнами русского неоклассицизма – начала и середины ХХ века.
Учебная и научная деятельность кафедры «Храмовое зодчество»МАРХИ: первые итоги и перспективы развития
Authors: Борисов Сергей , Коротаев Николай
Published: July 2024

Кафедра «Храмовое зодчество» Московского архитектурного института в настоящее время является единственной в системе высшего образования Российской Федерации, специализирующейся на архитектуре религиозных объектов. Кафедра обеспечивает ежегодный выпуск магистрантов, приобретающих широкий спектр знаний и умений в области храмовой архитектуры. В процессе обучения кафедрой реализуется метод привнесения в церковную архитектуру актуальных составляющих светских творческих концепций для выражения истин христианства через продолжение традиции. Изучаемые кафедрой «Храмовое зодчество» вопросы характеризуются отношением православия к историческим, социальным, экономическим, политическим процессам; к науке, образованию, культуре и искусству.Разработки кафедры в научно-исследовательской и проектной областях за 2016‒2023 годы позволяют обобщить результаты и сформировать перспективные направления деятельности. В статье рассмотрена структура преподавания кафедры, основанная на мультидисциплинарном подходе с учётом теологических, историко-архитектурных и проектных курсов, разработанная под руководством академика Г.В. Есаулова. Представлены цели и задачи деятельности кафедры, структурированы направления исследований выпускных квалификационных магистерских работ. Обозначено перспективное направление в научно-исследовательской деятельности кафедры, корреспондирующееся с теологическими аспектами.
Rare Case of Klippel Feil Syndrome Associated with Mirror Movements
Authors: S Dr. Sundari , V S Dr. Hamsa , R Dr. Ramya
Published: July 2024

Klippel Feil Syndrome (KFS) is a multisystem disorder with the typical clinical trial of short neck, restriction of headand neck movements and low posterior hairline and associated with anomalies of the urogenital, musculoskeletal, neurological andcardiovascular systems. Here is a case report of a young boy with history of abnormal head and upper limbs movements alongwith repeated bowing of head since the age of 6 months. He also had frequent falls with repeated minor trauma to the face.Antenatal and peripartum period was uneventful and child had no neonatal complications with normal development. Onexamination the child had abnormal head position with bowing, short neck and low hair line. Musculoskeletal system examinationrevealed decreased range of passive movements at cervical spine extension and lateral flexion with no focal neurological deficits.Further examination revealed Mirror movements (synkinesis) in the upper limbs. Mirror movements are the involuntarymovements of one body part that mirror intentional movements on the opposite side. Other Systemic examinations were normal.CT Cervical spine showed fusion of the upper three cervical vertebrae and the child was diagnosed as a case of klippel feil syndrometype 2 presenting with mirror movements. This rare case of klippel feil syndrome is being presented with the aim that such casesshould be detected and treated at an early stage to reduce the cosmetic & social stigma to the patient and parents. This casereport also gives a brief overview of associated features of KFS along with its management.