bluuebunny/crossref_metadata_2025 huggingface dataset:
A pilot study: Self Empowerment Therapy for depression associated with PTSD
Authors: Kaye Professor David
Published: December 2022

Background
Mental Health issues such as depression, PTSD, suicide etc., have become epidemics crippling western society requiring significant allocation of funds to address them. Research shows that that regardless of therapy used, nature and severity of the presenting problem and diagnosis, the modal frequency of patients attending counselling services is 1 (Talmon, M.,1990; Bloom, B.L., 2001; Young, J., 2018). With this in mind, Self Empowerment Therapy (SET) was developed by the author (Kaye, D., 2021).
Aims
The aim of this study was to look at effectiveness of SET as a single session in the treatment of depression.
Method
A cohort of 82 subjects were assessed using the Beck Depression Inventory at the start of the single-session and at the conclusion of the single-session.
Single session SET consisting of recording baseline measures, administration of 3 clinical exercises, questionnaire administration and results analysis.
The authors assert that all procedures contributing to this work comply with the ethical standards of the relevant national and institutional committees on human experimentation and with the Helsinki Declaration of 1975, as revised in 2008. All subjects executed informed consent forms.
Results
Results of the tests showed (n=82) showed clinically significant therapeutic effects from SET with 76.82 % improvement in depression symptoms.
Conclusions
Results for the in-person single shot two hour SET depression intervention demostrated clinically significant impact on depression associated with PTSD.
A Efficient Lattice-based Forward-Secure Linearly Homomorphic Signature Scheme for Network Coding
Authors: Wu Bin , Wang Caifen , Li Yahong , Shi Ning
Published: December 2022

The property that linearly homomorphic signature (LHS) enables linear computation on signed data makes this primitive commonly used to secure the network coding based application against pollution attacks. The security of LHS wholly depends on the security of secret signing keys; once a secret key is compromised, the application system’ security will be broken. However, as relatively insecure mobile devices are increasingly used in network coding application systems, the key exposure issue is becoming more prevalent. On the other hand, with the quantum technology development, some existing LHS schemes based on some traditional number-theoretic primitives are susceptible to quantum cryptanalysis. Hence, facing the dual threats of the exposure of secret keys in reality and the future effiffifficient quantum computers, we integrate forward security into LHS, and present a forward-secure identity-based LHS scheme (FSIBLHS) based on lattice assumptions, which achieves post-quantum security, and even if the current secret key is compromised, the validity of signatures of previous time periods is still guaranteed. We defifine the fifirst security model on forward security of LHS, and prove that the proposed scheme can resist adaptively chosen identity and datasets attack under lattice assumption. Moreover, compared with previous related works, the performance analysis shows that our scheme enjoys a comparable computation cost and has a lower communication cost, and provides higher security and stronger functionality.
Comparison of the effects of different combinations of expression regulatory elements on gene expression in mammalian cells
Authors: Zhou Lu-Yu , Zhang Shuang , Li Li-Yun , Liang Dong-Ge , Yu Hai-Shen , Chai Ya-Jing , Zhao Shi-Bo , Pan Jia-Jia , Zhu He-Shui , Zeng Lei
Published: December 2022

Background
At present, the function of numerous individual regulatory elements has been characterized extensively, but the combined effect of various cis-regulatory elements on gene expression in mammalian cells has been less discussed.
Results
In the present study, we examined the function of the combined effect of various cis-regulatory elements on gene expression in mammalian cells. To detect the function of different combinations of cis-acting elements on gene expression, we compared the effects of four promoters (PGK, Polr2a and EF-1α core promoter), two enhancers (CMV and SV40 enhancer), two introns (EF-1α intron A and hybrid intron), two terminators (CYC1 and TEF terminator) and their different combinations on gene expression. We constructed expression vectors with different combinations of these regulatory elements and detect the expression of eGFP by fluorescence intensity contrast and western blotting. Here we report that different combinations of cis-acting elements have a significant effect on protein expression. The vector with CMV enhancer, EF-1α core promoter and TEF terminator can express about three times higher eGFP than the unmodified vector in different animal cells.
Conclusions
We demonstrate that a direct combination of multiple regulatory elements capable of regulating gene expression did not exhibit synergistic effects. Our results show that regulation of protein expression can be achieved by optimizing the combination of cis-acting elements, and these findings can be used in biological applications that require regulation of gene expression.
The prevalence of frailty and its relationship with socio-demographic factors, regional healthcare disparities, and healthcare utilisation in the aging population across India
Authors: Singhal Sunny , Singh Sumitabh , Dewangan Gevesh Chand , Dey Sharmistha , Banerjee Joyita , Lee Jinkook , Upadhyaya Ashish Datt , Hu Peifeng , Goyal Laxmi Kant , Dey A B
Published: December 2022

Background
The burden of frailty in developing countries and its relationship with complex social structures, such as caste, religion and regional healthcare differences and its effect on healthcare outcomes are not well characterized. The aim of the study was to estimate frailty prevalence and its relationship with the socio-economic and regional factors and healthcare outcomes.
Methods
In this study, participants from the harmonized Diagnostic Assessment of Dementia for the Longitudinal Aging Study in India (LASI-DAD) were included. The frailty index (FI) was calculated using a 32-variable deficit model, with a value of ≥ 25% considered as frail. Data on demographic (including caste and religion) and socioeconomic profiles and healthcare utilization were obtained. The state-wise health index maintained by the government based on various health-related parameters was used to group the participants’ residential states into high-, intermediate-, and low-performing states. Multivariable and zero-inflated negative binomial regression was used to assess the relationship of frailty index with socio-demographic characteristics, health index and healthcare expenditure or hospitalization.
Results
Among the 3,953 eligible participants, the prevalence of frailty was 42.34% (men: 34.99%; women: 49.35%). Compared to high-performing states, intermediate- and low-performing states had a higher proportion of frail individuals (49.7% vs. 46.8% vs. 34.5%, p < 0.001). In the adjusted analysis, frailty was positively associated with age, female sex, rural locality, lower education level, and caste (scheduled caste and other backward classes). After adjusting for socio-economic profile, FI was inversely associated with the composite health index of a state (p < 0.001). FI was also significantly correlated with total one-year healthcare expenditure and hospitalization (p-value = < 0.001 and 0.02 respectively).
Conclusion
There is a high prevalence of frailty among older Indian adults that is associated with socio-demographic factors and regional healthcare performance. Furthermore, frailty is associated with increased healthcare utilization and expenditure.
Targeting UBR5 inhibits postsurgical breast cancer lung metastases mediated by CDC73 and p53
Authors: Ma Xiaojing , Yu Ziqi , Dong Xue , Song Mei , Xu Aizhang , He Qing , Li Huilin , Ouyang Wen , Chouchane Lotfi
Published: December 2022

UBR5 is a HECT domain E3 ubiquitin ligase that is frequently amplified in breast, ovarian, and prostate cancers. Heightened UBR5 plays an oncogenic role in promoting tumor growth through immune-dependent mechanisms. However, its mode of action in driving tumor metastasis has not been definitively delineated. In this study, we used a tetracycline (Tet)-inducible RNAi-mediated expression silencing cell system to investigate how UBR5 enables postsurgical mammary tumor metastatic growth in the lungs of mice without the impact of the primary lesion. In vitro, Ubr5 knockdown induced morphological and molecular changes characteristic of epithelial-mesenchymal transition (EMT). In vivo, UBR5 promoted lung metastasis in an E3 ubiquitin ligase-dependent manner. Moreover, doxycycline-induced knockdown of UBR5 expression in metastatic cells in the lung resulted in increased apoptosis, decreased proliferation, and prolonged survival, whereas silencing the expression of cell division cycle 73 (CDC73), a tumor suppressor and an E3 ligase substrate of UBR5, reversed these effects. Transcriptome analyses revealed a prominent role for the p53 pathway in dovitinib-induced apoptosis of tumor cells differentially regulated by UBR5 and CDC73. In human triple-negative breast cancer (TNBC) patient specimens, a strong inverse correlation was observed between UBR5 and CDC73 protein levels and reduced CDC73 expression at metastatic sites compared to primary lesions. Furthermore, a xenograft model of human TNBC recapitulated the metastatic properties and characteristics of the unique UBR5-CDC73 functional antagonism. This study unveils the novel and critical roles and relationships of UBR5, CDC73 and p53 in postsurgical breast cancer metastasis and implicates the potential of targeting this pathway in cancer therapy.
Anxiety, Depression and Quality of Life After Achievement of Inactive/Low Disease Activity in Axial-Spondyloarthropathy
Authors: Bayrak Esra Dilsat , Aktas Ilknur
Published: December 2022

Objectives
Axial-Spondylorthropathy (axSpA) is a common rheumatic disease in young and working age population and has an important physicosocial effects. The aim of this study is to investigate the frequency of anxiety and depression in axSpA patients who has inactive/low disease activity, explore the factors associated with anxiety and depression and whether the anti-TNF agents have an positive effect on anxiety-depression and QOL.
Methods
AxSpA patients who met the criteria for inactive or low disease activity according to ASDAS were included in the study. Baseline characteristics were recorded. Patients recieving anti-TNF and NSAID treatments were compared. Anxiety and depression were assessed by Hospital Anxiety and Depression Scale (HADS). QOL was measured with the EuroQOL (EQ5D).
Results
33.6% of patients were assessed for having probable anxiety and 47% for probable depression. There were no differences in terms of age, marital status, employement, positive family history, peripheral arthritis, enthesitis, mean HADS-A, HADS-D and EUROQOL between anti-TNF and NSAID teratments. Positive family history, peripheral arthritis and higher BASDAI were predictive for probable anxiety. Peripheral arthritis and higher BASDAI were predictive for probable depression. EUROQOL was correlated with high BASDAI, BASFI, HADS-A, HADS-D, peripheral arthritis and positive family history.
Conclusion
Regular psychosocial assessment should be the part of treatment of axSpA patients besides the control of disease activity and inflammation.
Aesthetic Oral rehabilitation with Digital cast partial denture, FPD and Composite restorations – A case report
Authors: Pradeep C , Lahori Manesh , Agarwal Abhinav
Published: December 2022

One of the conservative and affordable choices for treating partially edentulous arches that can improve quality of life overall is removable partial dentures.
However, the laboratory procedures involved in its fabrication are complex, time-consuming, and require manual dexterity.
The two methods of digitization used in RPD framework development are subtractive and additive methods. Using a computer numerical control machine, subtractive manufacturing entails machining the framework out of a metal block.
The fixed prosthesis is well adapted to the subtractive techniques. Due to longer manufacturing times, the complexity of the framework, the cost of the materials, and wear, their implementation is more challenging to build RPD framework.
This case report presents rehabilitation of a partially edentulous maxillary arch with DMLS co-cr Cast Partial Denture.
A fault feature extraction method of gearbox considering variable speed condition
Authors: Li Siyu , Cheng Zhonghua , Liu Zichang , Wang Yabin , Jia Xisheng
Published: December 2022

In this paper, a fault feature extraction method based on the combination of COT and VMD is proposed to solve the problem of fault feature extraction of gearbox under variable speed conditions. Firstly, a speed estimation method based on forward backward greedy algorithm and Fourier fitting is proposed to solve the speed estimation problem under variable speed conditions. Then, a feature extraction method based on computational order tracking (COT), variational mode decomposition (VMD) and fast kurtogram is proposed. COT is used to calculate the order. After the signal is decomposed by VMD, fast kurtogram is used to filter the modal components with obvious fault features, so as to extract fault features. Finally, combined with the analysis of actual equipment examples, the experimental results show that the steady state filtering can effectively filter the background noise and improve the signal-to-noise ratio. The rotation speed estimated by forward backward greedy algorithm and Fourier fitting is very close to the actual speed, which verifies that the method proposed in this paper can effectively solve the problem of fault feature extraction of gearbox under variable speed conditions.
Enhanced Removal of Organic and Inorganic Pollutants using Electrooxidation Integrated Membrane Bioreactor (IMBR) and validation through Lumped Parameter Kinetic modelling with thermodynamic parameter exploration in Pharmaceutical Wastewater Treatment
Authors: Palani Kavitha Nagrasampatti , Saravanakumar Naveen Kumar , Natesan Balsubramanian
Published: December 2022

The occurrence of fouling in Membrane Bioreactors (MBRs).reduces the performance of the system can be overcome by integrating electro-oxidation process in which different applied current density (CD) have been investigated. The optimal CD was 0.748 A/m2 which was suitable for the long-time operation of IMBR and observed that the removal percentile for total organic compounds (TOC), chemical oxygen demand (COD) was above 90% with total dissolved solids (TDS) of 60% at 400kPa constant pressure. Scanning electron micrographs (SEM) showed less void volume and pore constriction and the increase in permeate flux was 45% with extended backwashing time of 140 minutes. The fouling mechanism also verified by Hermia models, lumped parameter kinetic modelling and thermodynamic parameter with activation energy estimation exhibits lesser internal fouling of standard error 0.00459, 58.296 kJ/mol, − 0.1191 kJ/mol, 94.621 kJ/mol, 52.428 kJ/mol and the observed results and more reliable and feasible. The most striking observations in this study were that IMBR can be operated without the problem of filamentous bulking, and electro-oxidation significantly alternated the structural and morphological sludge flocs. The results implied that electro-oxidation might be the key factor for the success in fouling mitigation in IMBR.
Wood dust as an additive for starch-based biocomposite films
Authors: Kwaśniewska Anita , Świetlicki Michał , Kowalska Beata , Gładyszewski Grzegorz
Published: December 2022

The study aimed to investigate the effect of raw waste pine wood dust (Pinus sylvestris) from furniture production on polysaccharide biopolymer film properties. The obtained biocomposite films produced by the casting method were prepared with 20% glycerol and 0%, 5%, 10%, 15%, 20% and 25% of added wood dust in relation to the dry starch matter, respectively. Wood dust composition and particle size distribution analysis were performed. In order to evaluate the material surface properties, tests were carried out using an atomic force microscope (AFM) and a contact angle goniometer. The uniaxial tensile test examined the mechanical properties, and the tensile strength and Young’s modulus value were determined. In addition, the barrier properties, water solubility index and colour were also investigated. The research showed that wood dust affects the functional parameters of the obtained biocomposites. Wood dust content increase causes Young’s modulus value to rise with a progressive decrease in the max strain. The filler did not change the films’ wetting properties, and each had a hydrophilic surface regardless of the additive amount. The bio-sourced composites obtained are non-toxic and environmentally neutral materials suitable to apply in the packaging industry as well as the agriculture sector.
Importance of Trade Integration and Trade Complementarity inflow on the relationship between China and Europe & Central Asia
Authors: Shahzad Umer
Published: December 2022

The study aim is to investigate the Industrial, Agricultural, and Technological Bilateral Trade relationship between China and the Europe & Central Asia region over the period of 2000 to 2019 by employing the Revealed Comparative Advantage Index (RCA export), Trade Complementarity Index (TCI) and Trade Integration Index (TCD). The estimated results showed that there is a strong Bilateral Trade relationship between China and Europe & Central Asia. The estimated results of the Trade Complementarity Index (TCI) indicates that between 20 industries' product 17 have strong TCI between China and Europe, which showed that the export and import between China and Europe & Central Asia are matched, only three of the industries product, which are vegetable, Fuels, and Minerals are not matched strongly, the Trade Integration Index (TCD) between China and Europe from 2000 to 2019 is less than 1 that explains the Trade Integration Index between China and Europe are weak which give us knowledge that Chinese trade didn’t depend strongly on the Europe & Central Asia, estimated results of the Revealed Comparative Advantage Index (RCA export) between China and Europe examine that there have strong the Revealed Comparative Advantage between China and Europe of all 20 different industries product.
Optimization of HVAC Energy usage with Building Automation and Control Systems in Tropical Climates: a Review
Authors: Gaba Navneet
Published: December 2022

Improving the energy performance of buildings will be essential for countries around the world to reduce energy consumption and emissions. Building automation and control systems (BACS) play a crucial role in achieving this objective. Heating, ventilating and air conditioning (HVAC) systems are primary targets for improving energy efficiency through automation. In tropical and subtropical regions with high average temperatures cooling in commercial buildings such as offices has become essential for thermal comfort. This paper focuses on a comprehensive understanding of building automation and control systems as well as an analysis of their use in reducing HVAC energy consumption in commercial buildings utilizing available data and literature resources. A survey of 23+7 research papers and 2 books was carried out to understand the scope of HVAC energy optimization in commercial buildings with the use of BACS. The purpose of this paper is to raise awareness of these BACS systems and the significance of their application for energy optimization in buildings. The Heating, Ventilation, and Air Conditioning (HVAC) system of a commercial building is one of the largest energy consumers, especially in tropical climates. Building automation and control systems (BACS) are one of the most important enabling technologies for energy-efficient HVAC control in buildings. Automated starting and stopping of HVAC equipment reduces system operating hours, maintenance costs, energy costs and greenhouse gas (GHG) emissions, thereby reducing the building's carbon footprint while maintaining occupant comfort. This results in savings in the thousands of dollars annually.
The Effect of Scattered Multipurpose Trees (Erythrina Brucei Schweinf. And Croton Macrostachyus Hochst. Ex Delile) on Wheat (Triticum Aestivum L.) Yield in Southern Ethiopia
Authors: Bekele Daba Misgana , Hagos Tesfay Hailemarium , Selfeko Dereje Tsegaye
Published: December 2022

Integrating multipurpose trees on cropland with annual crops is common in Ethiopia. However, information on its impact on annual crop yield is scarce in many parts of the region. This study was to evaluate the effect of Croton macrostachyus Hochst. ex Delile (Euphorbiaceae) and Erythrina brucei Schweinf. (Fabaceae) on wheat crop yield in southern Ethiopia, Gamo Zone, Chencha district, Ayira kebele. Ayira kebele was selected purposively based on having abundant trees on cropland. Eight trees were selected based on having an approximately similar diameter at breast height, height, and crown area from a similar site. The wheat crops was sown under the canopy and outside the canopy of the selected trees and the biomass and yield were collected from 1/3m crown radius, 2/3m crown radius, edge of the crown, and outside the canopy of the trees by establishing 0.5m*0.5m plot. The wheat yields and biomass results were analyzed using two-way ANOVA by SAS Software version 9.0 and mean separation with LSD (%) at a 5% level of significance. The combined analysis of the variance of the study showed that the effect of the two tree species on the biomass and grain yield of wheat was significantly (P< 0.05) higher within the canopy of the tree than outside of the canopy. The findings of the present study will be helpful in knowing the effect of Croton macrostachyus Hochst. ex Delile (Euphorbiaceae) and Erythrina brucei Schweinf. (Fabaceae) on wheat yield. In this study, we found that both tree species would be incorporated into wheat cropping systems to improve the yield of wheat crops for resource-poor farmers as scattered multipurpose trees can be used as an economically feasible, environmentally friendly, and sustainable alternative production. Since both trees have a positive effect on wheat grain yield and plant biomass, expanding the knowledge of these trees in cropland is recommended.
The necessary and sufficient conditions for the real Jacobian conjecture
Authors: Tian Yuzhou , Zhao Yulin
Published: December 2022

We focus on investigating the real Jacobian conjecture. This conjecture claims that if F = (ƒ1 , . . . , ƒn) : Rn → Rn is a polynomial map such that det DF ≠ 0, then F is a global injective. In Euclidean space Rn, the Hadamard’s theorem asserts that the polynomial map F with det DF ≠ 0 is a global injective if and only if ∥ F (x) ∥ approaches to infinite as ∥ x ∥ → ∞. This paper consists of two parts. The first part is to study the two-dimensional real Jacobian conjecture via the method of the qualitative theory of dynamical systems. We provide some necessary and sufficient conditions such that the two-dimensional real Jacobian conjecture holds. By Bendixson compactification, an induced polynomial differential system can be obtained from the Hamiltonian system associated to polynomial map F. We prove that the following statements are equivalent: (A) F is a global injective; (B) the origin of induced system is a center; (C) the origin of induced system is a monodromic singular point; (D) the origin of induced system has no hyperbolic sectors; (E) induced system has a Ck first integral with an isolated minimun at the origin and k ∈ N+∪{∞}. The above conditions (B)-(D) are local dynamical conditions. Moreover, applying the above results we present a very elementary dynamical proof of the two-dimensional Hadamard’s theorem.
In the second part, we give an alternate proof of the Cima’s result on the n-dimensional real Jacobian conjecture by the n-dimensional Hadamard’s theorem
2020 Math Subject Classification: Primary 34C05. Secondary 34C08. Tertiary 14R15
Cytomorphometric assessment and micronuclei assay in iron deficiency anemic females – An Exfoliative Cytological Study
Authors: Rehani Shweta , Bala Jyoti , Bishen Kundendu Arya , Juneja Vishal , Sethi Sneha
Published: December 2022

Background: The ubiquitous form of iron is an essential nutrient for most tissues and its deficiency brings about recognizable deleterious effect on various tissues. Oral manifestation in iron deficiency anemia (IDA) are frequent and significant indicator of the underlying disease.
Aims: The aim of this study was to determine quantitative cytological changes in exfoliative buccal smears of iron deficiency anemic subjects, followed by a comparison with a control group on the basis of various morphometric parameters.
Material and methods: The study included 40 subjects (females with IDA) and 40 apparently healthy subjects (age range 6 – 60 years). Papanicolaou and Giemsa stained smears were prepared from the exfoliated buccal mucosal samples. The quantitative assessment of cellular diameter (CD), nuclear diameter (ND) and nuclear to cellular ratio (N:C) was done using Image J analysis software version 1.49t and average micronuclei count of 100 clearly defined unfolded epithelial cells for each subject was evaluated under light microscopy.
Results: This study shows that compared to the control group, IDA females for all age groups exhibited features like lower mean CD, higher mean ND, higher mean N: C ratio and increased average micronuclei count.
Conclusions: IDA brings about cytological changes in oral mucosa and the present study further substantiates this existing fact. Through the use of exfoliative smears, the early diagnosis, regular monitoring and post medication follow-up will have better patient compliance. Thus dental professionals should be encouraged to incorporate exfoliative cytology in their diagnostic aids.
Clinicopathological features and survival outcomes of colorectal medullary carcinoma: a retrospective study based on the SEER database
Authors: Han Lu , Zhang Yaping , Zhang Qun , Hu Jing , Li Li , Shi Xiao , Ding Zhou , Qian Xiaoping
Published: December 2022

Object: To investigate the relationship between clinicopathological characteristics and survival prognosis of patients with colorectal medullary carcinoma (MC), and to compare the prognostic differences between MC, colorectal neuroendocrine carcinoma (CRC-NEC) and colorectal neuroendocrine tumor (CRC-NET), in order to provide a more targeted treatment plan for colorectal cancer (CRC) and provide an evidence-based basis for evaluating the prognosis of patients. To provide a more targeted treatment plan for colorectal cancer (CRC) and an evidence-based basis for evaluating patient prognosis.
Methods: From 2010 to 2019, 495 patients with pathological diagnosis of MC, 2440 patients with CRC-NEC and 9626 patients with CRC-NET were collected from the SEER database. The differences in clinicopathological characteristics between the groups were compared and the corresponding survival curves were plotted. 1:1 Propensity Score Matching (PSM) was used to eliminate the differences in baseline information between the groups, and the Kaplan-Meier method and log-rank test were used to compare the survival rates of patients in different groups. Cox regression models were developed to assess the predictive value of potential predictors for patients' clinical outcomes.
Results: A total of 495 patients with MC were included in this study, and Multivariate analysis revealed that AJCC stage III+IV (HR=2.514, 95%CI: 1.796-3.519, P<0.001), positive tumor deposition (HR=1.723, 95%CI: 1.187-2.499, P=0.004), undergoing surgical treatment (HR=0.16, 95%CI: 0.065-0.393, P<0.001) and receiving chemotherapy (HR=2.328, 95%CI: 1.538-3.523, P<0.001) were potential independent risk factors on OS in MC patients. In addition, the OS and CSS of MC patients were significantly better than those of NEC patients before and after PSM matching (P<0.05); and the OS of MC patients was also better than that of CRC-NET patients before PSM matching (P<0.05), while the OS of MC patients was not significantly different from that of CRC-NET patients after PSM matching (P>0.05).
Conclusion: MC has unique clinicopathological features and its prognosis is better than that of CRC-NET and CRC-NEC.
A comparative analysis of road and vehicle qualities as factors of road traffic carnage in Nigeria
Authors: Eneh Chinemelum A. , Okosun Andy , Oloto Martin C. , Emenuga Veronica , Ehiogu Chizoba P. , Eneonwo Cosmas I. , Eneh Onyenekenwa C.
Published: December 2022

Background and Objective: Carnage on roads is a growing concern in Nigeria. Over 27 persons, equivalent to more than 4 families, die daily from road traffic crashes. Two direct factors of a road crash are road quality and vehicle quality. To interrogate and compare both factors to road traffic accidents, the longitudinal study regressed secondary data on death tolls against road quality and vehicle quality.
Materials and Methods: Data on the estimated number of vehicles imported into Nigeria (1992-2021) served as the indicator of vehicle quality on Nigerian roads. The longitudinal study regressed secondary data on death tolls (2013-2019) against road quality (2006-2019) and vehicle quality (1992-2021).
Results: Results showed that road quality is degenerating as well as vehicle quality in Nigeria, resulting in increases in the number of road traffic crashes and the attendant death tolls. For every 1% decrease in road quality, death tolls from road traffic crashes in Nigeria increased by 0.00642% at 5% significance, and for every decrease in vehicle quality, death tolls from road traffic crashes in Nigeria increased by 0.327% at 5% significance.
Conclusion: The study recommended increased advocacy on the sanctity of life and the need for the federal, state and local governments to prioritize policy and implementation of improving the road quality and vehicle quality to reduce road traffic crashes and save lives on Nigerian roads.
Modelling the electricity mix for Togo by 2050 using OSeMOSYS
Authors: Tchandao Esso-Wazam Honoré
Published: December 2022

This work uses bottom-up modeling to explore the future evolution trajectories of the electricity mix in Togo by 2050. The objective is to investigate the evolution of the mix and the future investments needed to achieve the sustainable energy and climate change goals. Three scenarios were developed using OSeMOSYS. The reference scenario, named Business As Usual, closely reflects the evolution of the Togolese electricity sector under a business-as-usual assumption and planned capacity increases up to 2030. The second scenario, Net Zero by 2050, is based on the first scenario while ensuring that CO2 emissions cancel out in 2050 by following the Weibull law. The third scenario called Emission Penalty aims not only at the integration of renewable energies like the second one but also at the least cost electricity mix if emission penalties are applied. The results of the cost optimization indicate that photovoltaic and importation are the optimal choices ahead of gas and hydropower. The renewable energy aspect of the electricity mix is more highlighted in the last scenario. At the same time, the model shows that greater energy independence is achievable at the cost of a transitory increase in the cost of the electricity system. A tenfold investment effort is needed in 2030 to ensure either continuity of the status quo or a shift in strategy.
Reprogramming of transcriptome after hormetic heat stress by the endoribonuclease ENDU‑2 improves lifespan and stress resistance in C. elegans
Authors: Xu Fan , Gromoff Erika D v. , Drepper Friedel , Knapp Bettina , Warscheid Bettina , Baumeister Ralf , Qi Wenjing
Published: December 2022

Any organism is constantly exposed to dangerous, potentially life-threatening environmental impacts that demand coordinated responses. Although acute stress responses as temporal reactions to unfavorable external or internal factors are well known, transient stress experiences may have long-term physiological consequences. The underlying mechanisms adjusting cellular activities across time scale is poorly understood. Here, we investigate the long-term alteration of C. elegans transcriptome after a short heat shock (HS) exposure and discovered that the canonical HS response is followed by a profound transcriptional reprogramming that affects many genes involved in innate immunity response. This transcriptional reprogramming depends on the function of the endoribonuclease ENDU-2 but not the heat shock factor 1 (HSF-1). ENDU-2 in this context co-localizes with chromatin and interacts with RNA polymerase Pol II to specifically regulate transcription in the post-HS period. Failure to activate this post-HS response does not impair survival of animals upon HS insult, but abolishes the hormetic HS mediated beneficial effects. In summary, our work discovers that the hormetic long-term effects of a transient HS are mediated by the RNA-binding protein ENDU-2 that determines aging and longevity.
Analysis of the ankle joint fixation methods in patients with failed treatment outcomes of distal tibia injuries and their consequences
Authors: Grazhdanov Konstantin A. , Zuev Pavel P. , Baratov Andrey V. , Sertakova Anastasiya V. , Rubashkin Sergey A. , Norkin Igor A.
Published: December 2022

We analyzed the treatment outcomes of distal tibia injuries and their consequences in 144 patients with terminal stages of post-traumatic ankle osteoarthritis. The research employed clinical and radiological methods as well as the Foot Function Index questionnaire. Surgical methods involved ankle arthrodesis and various combinations of grafts and fixators. It has been established that osteoplastic arthrodesis during as a part of surgical rehabilitation in patients with the consequences of ankle injuries complicated by the terminal arthrosis ensures a complete restoration of the support function in the injured lower limb as well as pain relief.
psycho-social stressors among hepatitis C virus patients and its relationship to anxiety, depression and adjustment
Authors: Haggag Abdelmotaleb Abdelkader
Published: December 2022

Background
This research aimed to identify psycho-social stressors among hepatitis C virus patients and its relationship to anxiety, depression and adjustment. An Internet-based cross-sectional study was conducted where the available sample was selected from 379 HCV patients and another uninfected sample consisting of 381 respondents, bringing the total to approximately 760 respondents between January 4 and October 28, 2021. Participants completed four self-reported scales. The scales included the psychosocial stressors of patients scale (PSPS), Beck depression inventory (BDI-I), the state-trait anxiety inventory (STAI) and general adjustment scale (GAS).
Results
The results reveal that there are differences between patients with HCV-positive, patients with HCV-negative and healthy people in the psychosocial stressors in favor of patients with HCV-positive. There was a positive correlation between psycho-social stressors of hepatitis C patients with anxiety, depression, adjustment and age. There were differences between patients with HCV and healthy people in the following variables: anxiety, depression, healthy adjustment, family adjustment, professional adjustment, social adjustment and general adjustment in favor of patients with HCV. There were differences between patients with HCV-positive and patients with HCV-negative in the following variables: anxiety, depression, healthy adjustment, family adjustment, social adjustment and general adjustment in favor of patients with HCV-positive.
Conclusions
This study recommended that care must be taken in the counseling and psychotherapy of HCV patients to reduce the mental disorders associated with the disease.
Asymmetry Behaviour of Real Exchange Rate Volatility and Trade Flows: a Bilateral Analysis
Authors: OLUBIYI Ebenezer , BIALA Musa
Published: December 2022

The debate on the effects of exchange rate volatility on trade is still ongoing. This study however focuses on how asymmetry behaviour in bilateral exchange rate influences trade between Nigeria and five of its major trading partners, namely France, US, Netherland, China and India. Data on relevant variables are obtained on monthly basis over the period of 2011:4 to 2020:12. Time varying variance (generalized autoregressive conditional heteroskedasticity – GARCH) is employed to generate the volatility series while nonlinear autoregressive distributed lag (NARDL) in the context of expected utility theory was employed. The NARDL results suggest that there exists both short and long run asymmetry behaviour of most of the bilateral real exchange rates. Specifically, positive change in bilateral real exchange rate volatility enhances exports to all the trading partners except US. Negative change in bilateral real exchange rate volatility facilitates exports to China, India and the US but inhibits exports to France and Netherland. The magnitude of positive change is stronger than the negative change in this regard. Both positive and negative change in bilateral real exchange rate volatility reduces imports from all the trading partners except from India. Following these results, some policy implications and recommendations are drawn. One of such recommendations is that the monetary authorities in Nigeria should expand the number of foreign currency in the basket for settling international transactions. In this regard, Yuan and Rupee are recommended to also be part of the major currencies.
JEL Classification: F14, F31, F41
Applying the Lifelong Machine Learning Paradigm in Tuberculosis Triage
Authors: Alves Regina , Tavares Frederico , Trajman Anete , Seixas José
Published: December 2022

Tuberculosis (TB) and pneumonia, including pneumonia from SARS-CoV-2 infection, are among the main causes of lower respiratory infections, which are the fourth cause of death worldwide. Recently, the World Health Organization recommended the use of computer-aided diagnosis (CAD) software as a tool to analyze chest radiographs (CXR) for TB screening and triage. Most CAD developed to date aim to screen exclusively for TB. This work applies the lifelong machine learning paradigm to detect both pneumonia and TB through CXRs and evaluate the models’ ability to retain and acquire knowledge. Two well-known lifelong learning models, the Efficient Lifelong Learning Algorithm (ELLA) and Learning without Forgetting (LwF), were applied to two public CXR datasets containing TB and pneumonia samples together with healthy CXR samples. Pneumonia detection was learned first and TB detection was learned as second task. The SP index, a function of sensitivity and specificity, was used to evaluate the models. We concluded that both algorithms were able to retain knowledge about pneumonia detection and were also able to learn TB detection.
TÜRK MİZAH BASINI ÜZERİNE GÖRSEL BİR İNCELEME: KARAGÖZ GAZETESİ
Authors: ARIKAN Abdulgani , GÜLŞEN YILMAZ Yasemin
Published: December 2022

Adını Türk gölge oyunundaki Karagöz tiplemesinden alan, Ali Fuat Bey’in sahibi olduğu Karagöz gazetesi “Pazartesi ve perşembe günleri çıkar siyasi, mizahi musavver halk gazetesi” sloganıyla 10 Ağustos 1908 tarihinde yayın hayatına başlamıştır. Haber alma, iletme, geçmiş olay ve görüntülere ilişkin imgeleri depolama, görsel ve güncel olan imgeyi algılayıp yorumlama açısından algı deneyimi, bir gazetenin dağıtımı gibidir. Bu benzerlikten yola çıkarak Karagöz gazetesinin, 13 Ağustos 1908 – 14 Eylül 1908 tarihleri arasında yayımlanmış sayılarından seçilmiş modernleşme süreci ile ilişkili karikatürlerin görsel algı kuramları açısından incelenmesi bu çalışmanın konusudur. Seçilen karikatürler modernlik bağlamında Gestalt, Marr’ın görsel algı, olasılıklı öğreti, doğrudan algılama, nörofizyolojik ve yapılandırmacı görsel algı kuramları açısından incelenmiştir.
EMRE KÖYÜ CARULLAH BİN SÜLEYMAN CAMİİ KALEMİŞLERİ
Authors: ONGAN Arkın , SAYIN Ayşe Zehra , BAYSAL Ali Fuat
Published: December 2022

Manisa’nın Kula ilçesine bağlı Emre köyünde bulunan Cârullah bin Süleyman Cami, mimari özelliklerinin yanı sıra tezyinatı itibarıyla da başlı başına ayrı bir değere sahiptir. Anadolu’da benzer örnekleri bulunan duvar resimleri ile donatılmış olan cami, XIX. yüzyılın başlarında Şeyhzâde Abdurrahman Efendi tarafından tezyîn edilmiştir. Yanında bulunan hamam kalıntıları ve çeşmesiyle birlikte bir külliyenin parçası olan cami, süslemelerinin sıra dışı olması itibariyle ilgi odağıdır. Süsleme kitabesinde ismi zikredilen Şeyhzâde Abdurrahman Efendi tarafından cami yoğun şekilde tezyîn edilmesi yapının nadir örnekler arasında olmasını sağlar. Bu çalışma ile halk arasında “resimli cami” olarak da anılan Cârullah Bin Süleyman Camii’nin, süslemeleri analiz edilmiş, resim ile dinî mimarinin birbiri ile çelişmeden bir araya getirildiği incelemiştir. Ayrıca duvar resimlerinin sembolik ifadeler taşıma ihtimali göz önüne alınarak, betimlenen öğeler sembolizm açısından değerlendirilmiştir. Çalışmamızın birinci kısmında Cârullah Bin Süleyman Cami, bânîsi ve kalemkârı hakkında kısaca bilgi verilmekte, ikinci kısmında caminin tezyinatı incelenmekte, üçüncü kısımda ise tezyinatın sembolik ifadeleri üzerinde durulmaktadır. Son kısmında ise caminin tezyinatı hakkında değerlendirmeler yer almaktadır.
EN-NÂSIR MUHAMMED DEVRİ MEMLÛK TÜRK DEVLETİ SAĞLAM, Ahmet, (2021), En-Nâsır Muhammed Devri Memlûk Türk Devleti, Türk Tarih Kurumu Yayınları, Ankara. ISBN: 978-975-17-4937-6, 1. Baskı, 439 s.
Authors: SUBAŞI Ömer
Published: December 2022

Manisa-Celal Bayar Üniversitesi Tarih Bölümü’nden 2008 yılında mezun olan Ahmet Sağlam, aynı üniversitenin Sosyal Bilimler Enstitüsü Ortaçağ Tarihi Anabilim Dalı’ndan Tolunoğullarının Kuruluşundan İhşidilerin Yıkılışına Kadar Mısır’da Gayri Müslimler adlı teziyle 2011 yılında yüksek lisans, yine aynı enstitünün Tarih Anabilim Dalı’nda Memlûk Sultanı Nâsır Muhammed b. Kalavun’un Siyasi Faaliyetleri (684-741/1285-1341) adlı tezi ile 2015 yılında doktor unvanını almıştır. Yazarımız hazırlamış olduğu bu çalışmasını 2021 yılında En-Nâsır Muhammed Devri Memlûk Türk Devleti ismiyle kitap hâline getirerek okurların beğenisine sunmuştur.
Türk-İslâm coğrafyası önce Haçlıların işgaline, daha sonra Moğolların istilâsına maruz kaldı. Yaşanan siyasi ve askeri gelişmeler sonucu 13. yüzyılın ortalarında çoğunluğunu Kıpçak Türklerinin oluşturduğu üst düzey emîrler Mısır’da Memlûk Türk Devleti’ni kurdular. Memlûk askeri sınıfının irade ve idaresinde şekillenen devlette, Sultan Baybars devri (1260-1277) kuruluş, Sultan Kalavûn devri (1279-1290) yükseliş dönemi olmuştur. Sultan Nâsır Muhammed’in üçüncü saltanat devri (1310-1341) ise devletin zirve dönemi olarak tarihteki yerini almıştır.
BİZANS VE MÜSLÜMAN TÜRK ANADOLU’NUN DOĞUŞU (1040-1130) Beihammer, Alexander Daniel, (2022), Bizans ve Müslüman Türk Anadolu’nun Doğuşu (1040-1130), çev. Tarık Özbek, Ankara: Koyu Siyah Yayınları, ISBN: 978-605-69807-8-7, 443 s.
Authors: ALTUNSOY Nazlı
Published: December 2022

Dünya tarihinde önemli dönüm noktalarından birini teşkil eden Anadolu coğrafyasının Türkleşmesi hadisesi tarihte hak ettiği değeri göremeyen konulardan birisidir. Sonuçları itibariyle Orta Çağ’ın ve sonrasının, hatta günümüzün, önemli devletlerini, coğrafyalarını, kültürlerini etkilemiş olan meseleye değinen tarihçiler ise genellikle ifrat-tefrit arasında bir bakış açısı ile değerlendirmeler yapmışlardır. Ancak konunun günümüzde giderek artan bir ilgiye mazhar olduğu da artık görülmektedir. Tanıtımı yapılan eser de bu yolda önemli bir boşluğu dolduran az sayıdaki çalışmalardan biridir
Artekale 6 (Plentzia, Bizkaia). Un nuevo asentamiento al aire libre de corta duración del Paleolítico Medio en Uribe Kosta
Authors: Rios-Garaizar Joseba , Lecanda José Ángel , Ortega Ander
Published: December 2022

En el transcurso de una intervención arqueológica en el solar nº 6 de la calle Artekale 6 de la villa de Plentzia (Bizkaia) se localizó un conjunto lítico sobre el sustrato rocoso y bajo un depósito de arcillas de 40 cm de espesor. En este trabajo se describe este conjunto de núcleos y lascas, y se propone una atribución del conjunto al Paleolítico Medio, probablemente reciente. Además, se discute el papel de estos breves asentamientos en las estrategias de asentamiento de los Neandertales en esta región.
Aspectos iniciais da implementação do Novo Ensino Médio no estado de Mato Grosso
Authors: Bonamino Alicia , Ferreira Nathacha Monteiro , Muylaert Naira
Published: December 2022

O artigo tem como objetivo compreender como se desenvolve a implementação do Novo Ensino Médio (NEM) no Estado do Mato Grosso (MT), segundo características vigentes em 2020. A implementação do NEM envolve regras, relações federativas e entre atores burocráticos, que são analisadas a partir de referenciais da Ciência Política, notadamente do binômio ambiguidade-conflito (MATLAND, 1995) e da visão de política pública como processo incremental (LINDBLOM, 1979). O estudo observou que a implementação do NEM tem dois resultados marcantes i. realiza-se em um contexto de natureza experimental, propiciado pela ambiguidade das regras, que permitem interpretações diferentes, e pelo baixo questionamento dos atores estaduais sobre a necessidade da reforma; e ii. acontece de forma pontual, priorizando a expansão de iniciativas em curso e aderentes às propostas do Ministério da Educação – MEC. Nesse sentido, em MT, o NEM foi marcado por ações prévias que aconteceram por indução e incentivo do Governo Federal.
Truncated modernity and decentralization of educational management in Peru
Authors: Rojas Haydeé Liliana Vera , Silva Antonia Almeida
Published: December 2022

Este artículo analiza la relación entre modernización y descentralización de la educación en el Perú, durante el gobierno del presidente Alan García Pérez, de 2006 a 2011, cuando se instituyó el Plan de Municipalización de la Gestión Educativa y el Esquema del Plan Piloto 2007. Es una investigación documental, con un enfoque crítico, teniendo como fuentes documentos oficiales, impresos o digitales, además de la bibliografía calificada. Las siguientes categorías orientan el análisis: gestión, descentralización y modernidad. La investigación reveló que la implementación de la política de descentralización de la gestión, apoyada en la municipalización, resultó en la fragmentación de las acciones del Estado y la promoción de la autonomía por decreto. La modernidad se expresó, en el contexto, como un ingrediente de la persuasión ideológica a favor de los intereses privados y no ha logrado cambios en términos de desregulación y retorno del poder del Estado a la sociedad.
Relações intergovernamentais na implementação do Programa Brasil Profissionalizado
Authors: Pazolini Michele , Araujo Gilda Cardoso de
Published: December 2022

Objetiva analisar a implementação do Programa Brasil Profissionalizado e problematizar o papel das relações intergovernamentais para sua concretização a partir do estudo de caso no Estado da Bahia (2007-2020). Por meio de análise documental, buscou-se compreender de que modo a cooperação entre os entes federados, influenciou na implementação do referido programa. Para tanto, utilizou-se as contribuições teóricas de Leonardo Secchi sobre o ciclo de políticas, Gabriela Lotta sobre a implementação de políticas, Sônia Draibe sobre os subprocessos de implementação e Marta Arretche acerca da influência das relações intergovernamentais na implementação de programas. Os resultados evidenciam os entraves entre formuladores e implementadores do programa, e a importância da função de assistência técnica da União. Considera-se que o processo de implementação do PBP no Estado da Bahia teve obstáculos tanto no nível federal quanto no nível estadual, com traços marcantes de ausência de mecanismos de cooperação entre os entes federados.