bluuebunny/crossref_metadata_2025 huggingface dataset:
Building Harmony among Polygamic Family
Authors: Rodliyah St.
Published: December 2021

Abstract: Poligami adalah; ”Ikatan perkawinan yang membolehkan seorang laki-laki memiliki lebih dari satu wanita sebagai istrinya di waktu yang bersamaan”. Poligami juga merupakan suatu bentuk perkawinan yang tidak dilarang oleh agama Islam, namun kebolehannya bukan berarti mempermudah seseorang untuk berpoligami, melainkan mewajibkannya untuk memenuhi persyaratan yang telah ditentukan dan alasan-alasan yang rasional, sebagaimana yang telah ditentukan dalam beberapa undang-undang yang berlaku di Indonesia, salah satu ketentuannya ada dalam ”Kompilasi Hukum Islam”. Dalam relasi keluarga poligami seringkali mengalami berbagai permasalahan salah satunya adalah ketidak-rukunan dan ketidakadilan (nafkah lahir maupun batin). Penelitian ini bertujuan untuk mendeskripsikan pola interaksi keluarga poligami dengan menggunakan pendekatan silaturahmi dalam membangun kerukunan keluarga. Pendekatan silaturahmi ini diharapkan mampu menjadi pendekatan persuasif bagi keluarga poligami untuk menjalin komunikasi secara harmonis, sehingga tujuan perkawinan sakinah, mawaddah warohmah tetap bisa dicapai.
Meningkatkan Kesadaran Pengasuhan Anak di Era Digital Melalui Ceramah Berbasis Multimedia
Authors: Damayanti Eka , Ahmad Arifudin , Nurhasanah Nurhasanah
Published: December 2021

Abstrak: Penelitian ini bertujuan untuk mengetahui peningkatan kesadaran pengasuhan anak di era digital melalui ceramah berbasis multimedia. Penelitian ini merupakan hasil pengabdian kepada masyarakat dalam bentuk ceramah menggunakan multimedia. Populasi dalam penelitian pengabdian ini terdiri dari 120 ibu-ibu yang terhimpun dalam majelis taklim Kecamatan Nuha. Sampel sebanyak 18 orang yang terpilih secara random. Instrumen pengumpulan data menggunakan skala psikologi melalui google formulir dan data yang terkumpul dianalisis menggunakan analisis statistik deskriptif. Hasil penelitian menunjukkan adanya peningkatan kesadaran pengasuhan yang diawali dengan peningkatan pemahaman terhadap perkembangan anak dengan skor 20 dan pemahaman terhadap dampak gadget pada perkembangan anak dengan skor 20. Lanjut Skor peningkatan kesadaran terhadap konsep Islam dalam pengasuhan yaitu 17, dan Skor kesadaran akan tanggung jawab orang tua dalam mencegah dampak gadget yaitu 18. Terakhir, skor peningkatan kejelasan langkah-langkah dalam mencegah dampak gadget yaitu 25 dan kesiapan menjalankan atau menerapkan mencegah dampak gadget yaitu 19.
IMPLEMENTASI PEMBELAJARAN KONTEKSTUAL (CONTEXTUAL TEACHING AND LEARNING) DI LUAR KELAS ERA COVID-19 MADRASAH ALIYAH BILINGUAL KRIAN SIDOARJO
Authors: Wasyik Torikhul , Syafi'i Imam
Published: December 2021

Abstrak: Dalam kondisi pandemi covid-19 yang tidak menentu menuntut adanya perubahan dalam proses pembelajaran. Madrasah Aliyah Bilingual adalah salah satu Madrasah yang melakukan inovasi pembelajaran yang di sesuaikan dengan keadaan di masa pandemi Covid-19. Tujuan penelitian adalah untuk mengetahui implementasi metode pembelajaran Luar kelas dengan model contextual Teaching and learning (CTL) di era Covid-19. Metode penelitian adalah metode  diskriptif dengan pendekatan kualitatif. Teknik pengumpulan data adalah dengan cara wawancara, observasi dan dokumentasi. Analisis yang di gunakan adalah studi content analysis yaitu penelitian yang melakukan pembahasan dari sebuah informasi tertulis secara dalam. Adapun subyek yang digunakan dalam penelitian adalah Kepala sekolah, waka kurikulum, Guru , dan 3 siswa. Hasil penelitian  membuktikan bahwa implementasi pembelajaran pada masa pandemi  di Madrasah Aliyah Bilingual terbagi terbagi menjadi dua masa yaitu  Pandemi I dan masa Pandemi II.Pada msa Pandemi I pembelajarannaya masih berjalan normal, hanya tetap memakai standar protokol kesehatan. Sedangkan pembelajaran pada masa Pandemi II adalah pembelajaran dengan model Contextual Teaching and learning (CTL)  yang terdiri dari 7 elemen yaitu siswa melakukan kontruksi, memiliki inquiry, bertanya, model masyarakat belajar, guru enjadi model,refleksi kegiatan,penilaian obyektif. Dan hasilnya pembelajaran masa pandemi tetap berjalan dengan baik.

 

Kata kunci : Pembelajaran, Luar kelas, CTL
Human rights and the borders of the human
Authors: Anne Brown M.
Published: December 2021

Notions of human rights and the technologies deploying those notions, legally, institutionally, in advocacy and social discourse, enact a tangled knot of contesting and asserting borders. Universalist assertions of human rights seek to transcend national borders, appealing to a wider grasp of the human, but the formal pursuit of rights establishes rights as mutually constitutive with the state. In advocacy, calling on human rights is a way of recognising people’s political, economic and socio-cultural needs, dignity and suffering, beyond state borders. The idea of the human and the universal implicit in prevailing notions of human rights, however, reproduces dominant Eurocentric ontologies of individual and collective life, and patrols a narrowly conceived territory of the universal. These ontologies can be profoundly counterproductive in practice. Because notions of human rights are one of the few internationally available tools for working against the systemic imposition of suffering, we need to work with them in ways that are more open to different ways of being human and of grasping our individual and collective lives. The discussion concludes by sketching a more relational, dialogic conception of human rights.
Radical Traversals
Authors: EDD SIERRA
Published: December 2021

In Radical Traversals, Sierra Edd combines work on Indigenous art practice and production, politics of aesthetics, and temporal sovereignty, to highlight the potentialities of decolonial imagining and interpretative methods of listening in an analysis of the digital music collection called the Indigenous Futurisms Mixtape. Edd examines how sonic affect and the remix form create spatial and temporal multidimensionality or hyper-presence, to disrupt Western orders of objecthood and colonial logics in music. Drawing on epistemological provocations in Native and Indigenous studies, Black diaspora studies, and Sound studies, this paper uses a theoretical framework of traveling Indigeneity to center collaboration and theorizations on decolonial imagination which describes emergent radical envisioning and world-making as a conceptual tool of troubleshooting. To foreground the engagement with Indigenous and Afro-Indigenous sound and aesthetics in music, Edd uses a method of close-listening, a heterogeneous intimacy or a whole-body encounter with sonic (meta)physics and acoustics. This paper illustrates how listening and engaging with the Mixtape’s political aesthetic form encourages decolonial imagining and employs micro-scale resurgence enacted in quotidian intellectual and emotional knowledge building.
Preserving Values
Authors: DE LEON JUSTIN
Published: December 2021

This article explores the prevenance of militarization within the important cultural and political space of the powwow. Finding popular explanations of military service (such as poverty, lack of opportunity, and desired upward social mobility) insufficient in explicating the visibility of militarization, this work illustrates how colonially suppressed values have been enacted through the creation of new symbols and forms of practice. Looking to the use of warrior staffs, the Lakota sacred numbers, and the Lakota Flag Song, the article focuses on warriorhood and illustrates how traditional cultural practices are preserved through cunning navigations and transformations of colonial landscapes, allowing for a creative expression of individual and communal sovereignty.
Generative Refusal: Creative Practice and Relational Indigenous Sovereignty
Authors: WRIGHTSON KELSEY R.
Published: December 2021

This article critiques narrow conceptions of sovereignty, while holding up Indigenous practices of sovereign place making and creative relational sovereign enactment. I come into this contestation by thinking through creative acts of sovereignty as a generative praxis. Informed by these practices offers a new way of thinking about sovereignty as practiced, generative and relational. Grounded practices of Indigenous peoples in Denendeh (Northwest Territories, Canada) and the authors own experience as a settler living and working in Denendeh, this article also offers a space to think through ‘refusability’ as relational response.
Can There Be Justice Here?
Authors: CHAO SOPHIE
Published: December 2021

This article examines the intersecting forms of social and environmental injustice shaping the lifeworld of Indigenous Marind communities and their more-than-human ecologies in the Indonesian-controlled province of West Papua. Over the last decade, large-scale deforestation and monocrop oil palm expansion have radically undermined Marinds’ intimate and ancestral kinships with sentient forest plants and animals, as well as the moral principles that undergird interspecies relations. These transformations are exacerbated by conservation practices that are undertaken in the name of corporate sustainability but that are problematically premised upon an assumed divide between humans and the environment. The exclusion of Marind from natures both exploited and preserved sits in turn within a long-standing and ongoing history of violence and discrimination perpetrated against West Papuans under Indonesian rule. Drawing from Marind philosophies, practices, and protocols of more-than-human relationality, I examine how Marind conceive and contest the possibility of justice now and in the future—for themselves, forest organisms, and oil palm—amidst multiple, overlapping, and intersecting injustices provoked by capitalism, conservation, and colonialism. I invite an expansion of the scope and subjects of justice beyond the human that remains nonetheless acutely attentive to the persistence of capital-colonial regimes systematically positioning Indigenous peoples as killable before the law.
Embedded Bordering
Authors: MCEVOY JOSHUA K. , MIDZAIN-GOBIN LIAM
Published: December 2021

Borders and bordering practices can be understood as both an act of sovereign authority and establishing the contemporary international system. The drawing of borders also simultaneously legitimizes the state’s sovereign authority, creating a political community ‘inside’ borders through which modern politics takes place. These processes are especially pertinent for settler states such as Canada, whose sovereign authority over its recognized territory is contingent on the erasure of Indigenous sovereignty. However, Indigenous nations reject Canadian claims of settler authority and legitimacy, instead continuing to uphold their own modes of governance and relationships to territory. This contestation of settler territoriality is practiced in various ways, with this article exploring how energy utility governance and infrastructure act as bordering practices—that is, as a productive means of manifesting and demonstrating territorial authority. Through the British Columbia Utilities Commission’s Indigenous Utilities Regulation Inquiry, we explore the contestation of territory through what we refer to as ‘embedded bordering’. In doing so, we identify a tension between ongoing settler moves to dispossession alongside decolonial potential in the border-making practices of energy governance and infrastructure.
Nano White Food and the Reproduction of Whiteness
Authors: LYONS KRISTEN , FREDERICKS BRONWYN , BRADFIELD ABRAHAM , MAYES CHRISTOPHER , KOERNER CATHERINE
Published: December 2021

Since colonisation began in Australia, it has transformed the ecological, social, cultural, and economic bases of the biggest estate on earth, with outcomes driving the disruption of Indigenous food sovereignty, foodways and food knowledges alongside the reproduction of Whiteness. This article critically examines the place of White food, including the case of nanotechnologies, in the expansion of the settler colonial frontier, and its impacts for Indigenous health and relationships with food. To do this, we consider a widely commercialised nano-food application: the addition of nano-scale titanium dioxide to make foods White. Nano White food provides a unique lens to examine White authority and control across settler colonial food systems. We consider some of the impacts arising from this global colonial power matrix—to which Whiteness is organising principle for domination—for Aboriginal and Torres Strait Islander health, justice, and rights. We argue that unsettling Whiteness is vital to redressing the violence wrought by settler colonial agri-food systems, and for re-centring living ecologies and interconnected systems across foodways.
A new extension of Odd Half-Cauchy Family of Distributions: properties and applications with regression modeling
Authors: Chakraburty Subrata , Alizadeh Morad , Handique Laba , Altun Emrah , Hamedani G. G.
Published: December 2021

The paper proposes a new family of continuous distributions called the extended odd half Cauchy-G. It is based on the T
–
X construction of Alzaatreh et al. (2013) by considering half Cauchy distribution for T and the exponentiated G(x;ξ) as the distribution of X. Several particular cases are outlined and a number of important statistical characteristics of this family are investigated. Parameter estimation via several methods, including maximum likelihood, is discussed and followed up with simulation experiments aiming to asses their performances. Real life applications of modeling two data sets are presented to demonstrate the advantage of the proposed family of distributions over selected existing ones. Finally, a new regression model is proposed and its application in modeling data in the presence of covariates is presented.
A study on exponentiated Gompertz distribution under Bayesian discipline using informative priors
Authors: Aslam Muhammad , Afzaal Mehreen , Ishaq Bhatti M.
Published: December 2021

The exponentiated Gompertz (EGZ) distribution has been recently used in almost all areas of human endeavours, starting from modelling lifetime data to cancer treatment. Various applications and properties of the EGZ distribution are provided by Anis and De (2020). This paper explores the important properties of the EGZ distribution under Bayesian discipline using two informative priors: the Gamma Prior (GP) and the Inverse Levy Prior (ILP). This is done in the framework of five selected loss functions. The findings show that the two best loss functions are the Weighted Balance Loss Function (WBLF) and the Quadratic Loss Function (QLF). The usefulness of the model is illustrated by the use of real-life data in relation to simulated data. The empirical results of the comparison are presented through a graphical illustration of the posterior distributions.
The problem of statistical assessment of the potential for the development of regional integration processes
Authors: Osaulenko Oleksandr , Bulatova Olena , Zakharova Olha , Reznikova Natallia
Published: December 2021

The present article illustrates the use of integrated indices to evaluate the potential for the development of regional integration processes. The study examines a new research and methodological approach, which involves the use of an integral index of the potential for the development of integration processes, proposed with regard to the intensity of the influence of internal and external factors on integrative relations development. The application of the above-mentioned integrated index in a comparative analysis of the potential for the development of integration processes allows a comprehensive and quantitative description of the current regional integration processes taking place in the modern economy under certain regional models.
Enterprise Risk Management and Risk Culture in Construction Public Listed Companies
Authors: Wong Ching Ching , Mohd Rahim Faizul Azli , Loo Siaw Chuing
Published: December 2021

Inadequate risk management and lack of risk culture can expose a company to unexpected risk events, which can negatively affect its performance. However, there are inconsistencies in suitable dimensions to measure the enterprise risk management (ERM) construct, as well as insufficient embedding strategies for risk culture. This study aims to identify the ERM practices and risk culture dimensions among the Malaysian construction public listed companies (PLCs). The roles of top management and chief risk officer/risk manager in influencing ERM and risk culture are also explored. A total of 46 annual reports and 10 interviews of industry practitioners were analysed using content analysis. The analysis of the annual reports found that risk policy and risk appetite/tolerance, monitoring key risk and accountability are the three dimensions of risk culture. In addition, based on the interviews, reward and recognition and internal relationships were identified as the two dimensions of risk. Top management and risk manager were found to be the primary drivers of ERM programme and risk culture in construction PLCs. The results of this study are used to formulate a survey instrument for the subsequent data collection to test the proposed theoretical model.
Development of Augmented Reality Application for Onsite Inspection of Expressway Structures Using Microsoft HoloLens
Authors: Keang Ang Kouch , Panuwatwanich Kriengsak , Sancharoen Pakawat , Sahachaisaree Somporn
Published: December 2021

This research introduces an augmented reality (AR)-based approach for the onsite inspection of expressway structures by developing an AR application, namely HoloSpector, deployed on the first generation of the Microsoft HoloLens headset. It was tested by a focus group of 10 postgraduate students, followed by three inspectors from the Expressway Authority of Thailand (EXAT), to investigate the practical applicability of the application. A questionnaire was employed as a research tool for measurement and assessment of the application and the HoloLens in this study. The results of this study indicated that the developed digital approach was satisfactory, easy to use and learn, useful, user-friendly and practical for EXAT expressway inspections; the users also intended to use it. Compared to the conventional approach, the current data communication and management could be significantly improved; this digital approach has the potential to help save resources, time and cost and increase work productivity.
Ibrutinib as First-Line Therapy in High-Risk Chronic Lymphocytic Leukemia: Case Reports
Authors: Kurkina Nadezhda Viktorovna , Repina E.A.
Published: December 2021

In the selection of the optimal specific therapy in chronic lymphocytic leukemia (CLL), a crucial role is played by the determination of risk groups. The CLL International Prognostic Index takes account of unfavorable del(17p), del(11q) cytogenetic abnormalities, and/or TP53 gene mutations as well as the mutation status of immunoglobulin heavy chain variable region genes (IGHV). The absence of IGHV gene mutations is often associated with such prognostically unfavorable genetic markers as del(17p), del(11q), trisomy 12, and TP53 mutation. The combinations of this kind affect the prognosis and overall survival rate. Besides, in high-risk CLL the efficacy of therapy is rather low and the development of refractoriness is possible. In such patients the use of Bruton tyrosine kinase inhibitor as first-line therapy considerably increases the probability of long-term remission. The present paper provides the analysis of clinical and hematological efficacy and tolerance of ibrutinib as first-line therapy in highrisk CLL. Ibrutinib shows high efficacy and low toxicity. The use of ibrutinib as first-line therapy effectively reduces the probability of CLL progression, which is especially critical in high-risk patients, i.e., with 17p deletion and TP53 gene mutation.
Decision Support System Design Model for Choosing Effective Learning Method in Higher Education Institution
Authors: Febriana Trisna , Budiarto Arif
Published: December 2021

In an educational institution, especially higher education, producing qualified graduates is the highest priority achievement. The quality of the graduates is highly dependent on the applied learning method. However, sometimes universities have difficulty in determining appropriate learning for their students. Determination of this decision requires a tool that can facilitate decisionmakers in analyzing all the considerations in choosing decisions. Another challenge is when the decision is shared among multiple stakeholders with equal contribution. It consequently creates a need for a mechanism that can provide an equal contribution for each stakeholder. The research tries to create a model to design a tool that can determine the decisions that need to be taken. This model is built with the Multi-Criteria Decision Analysis (MCDA) approach. MCDA is selected because it can be implemented in a collaborative ecosystem where multiple stakeholders are involved. Then, a literature study is conducted to determine the attributes and decision-making parameters. In addition, the primary data derived from interviews to a total of 40 respondents consisting of students, lecturers, and staff are taken into consideration to complete the literature study. The literature review and interview output are then translated to some parameters that influence an effective learning system. The result shows that this model can be used as a reference in developing a web-based application as an implementation of MCDA.
Probabilistic interval estimation of design floods under non-stationary conditions by an integrated approach
Authors: Zhou Yanlai , Guo Shenglian , Xu Chong-Yu , Xiong Lihua , Chen Hua , Ngongondo Cosmo , Li Lu
Published: December 2021

Quantifying the uncertainty of non-stationary flood frequency analysis is very crucial and beneficial for planning and design of water engineering projects, which is fundamentally challenging especially in the presence of high climate variability and reservoir regulation. This study proposed an integrated approach that combined the Generalized Additive Model for Location, Scale and Shape parameters (GAMLSS) method, the Copula function and the Bayesian Uncertainty Processor (BUP) technique to make reliable probabilistic interval estimations of design floods. The reliability and applicability of the proposed approach were assessed by flood datasets collected from two hydrological monitoring stations located in the Hanjiang River of China. The precipitation and the reservoir index were selected as the explanatory variables for modeling the time-varying parameters of marginal and joint distributions using long-term (1954–2018) observed datasets. First, the GAMLSS method was employed to model and fit the time-varying characteristics of parameters in marginal and joint distributions. Second, the Copula function was employed to execute the point estimations of non-stationary design floods. Finally, the BUP technique was employed to perform the interval estimations of design floods based on the point estimations obtained from the Copula function. The results demonstrated that the proposed approach can provide reliable probabilistic interval estimations of design floods meanwhile reducing the uncertainty of non-stationary flood frequency analysis. Consequently, the integrated approach is a promising way to offer an indication on how design values can be estimated in a high-dimensional problem.
Toward sustainable water resources management: critical assessment on the implementation of integrated water resources management and water–energy–food nexus in Afghanistan
Authors: Shams Ajmal Khan , Muhammad Nur Shazwani
Published: December 2021

Afghanistan has abundant water resources; however, the current state of affairs is dismal because of the lack of integrated water resources management (IWRM) practices and prolonged war and conflict in the country. Therefore, there is a need for a systematic approach to water management, which can be materialized by integrating IWRM and the water–energy–food (WEF) nexus approach to maintain a critical balance of available water resources and their various uses at the national level. This study provides a comprehensive assessment of Afghanistan's water resource management, including the current state, challenges, opportunities, and way forward. The identified challenges are categorized as social and environmental issues, engineering and technical and regulatory, policy and government role. These challenges are inter-connected and a novel framework toward the implementation of IWRM and the WEF nexus in Afghanistan is proposed. This framework can be used by the relevant stakeholders to prepare a roadmap for sustainable management of water resources. Such integrative approaches will enhance Afghanistan's water, food, and energy security and significantly contribute to its economic development. Moving forward, the Afghanistan government must play a crucial role with regards to the efficient management of the country's water resources in an integrated manner as suggested in this paper.
Monitoring the health status of water mains using a scorecard modelling approach
Authors: Huang Yuzhi , Rameezdeen Raufdeen , Chow Christopher W. K. , Gorjian Nima , Li Yangyue , Liu Zijun , Ju Peiqing
Published: December 2021

There has been considerable research into prediction of water mains failure, however, those models are very complex and fail to convey the message of the health status of an asset to the relevant stakeholders. The study developed a ‘pipe health scorecard’ based on historical failure data which could be used for operation, maintenance, refurbishment, or replacement decisions by a water utility. This scorecard model was developed by using 160,413 pipe-condition data sets from the South Australian Water Corporation over ten years. Measures such as the Kolmogorov–Smirnov (KS) statistic, Area Under the ROC Curve (AUC), and Population Stability Index (PSI) showed the model is strong enough to predict the health status of water mains. The study found the factors influencing water mains failure to be in the order of importance: length, material, age, location (road vs verge), diameter, and operating parameters. The development of a simple but reliable model for the assessment of the health status of water mains will have major benefits to the water utility with the ability to identify and potentially replace water pipes prior to failure. Additional benefits of flexible scheduling of maintenance and replacement programs would contribute to cost savings.
Groundwater recharge pathway according to the environmental isotope: the case of Changwu area, Yangtze River Delta Region of China
Authors: He Liang , Zhang Junru , Chen Suozhong , Hou Manqing , Chen Junyi
Published: December 2021

Groundwater recharge is an important factor affecting water circulation. As groundwater has slow seepage, directly observing the seepage velocity and recharge path of groundwater in the aquifer is difficult. Environmental isotope technology has become an important means to clarify the mechanism of groundwater movement and the mechanism by which groundwater recharges from the micro and macro perspectives. The Changwu area of Jiangsu Province was taken as an example to identify the recharge sources of groundwater and the recharge paths of groundwater and surface water by using the measured data of isotopes D, 18O, 34S, and T. The results indicated that the shallow aquifer and the I confined aquifer in the Changwu area are mainly recharged by precipitation and surface lake water. The II confined aquifer along the Yangtze River is recharged by modern precipitation. Moreover, the II confined aquifer in the Henglin area was recharged by the ancient Yangtze River before 4,000 years ago, and no recharge relationship exists now. the recharge condition of the II confined aquifer around the northwest of Gehu Lake is in the climate environment of 8,000 years ago and was caused by the surface depression lake water at that time. Additionally, the concealed limestone aquifer is primarily supplied by the II confined aquifer, while the concealed sandstone aquifer supplies the II confined aquifer. Hence, to find out the recharge conditions of groundwater aquifers based on the environmental isotope is conducive to scientific and reasonable evaluation of groundwater resources and to ensure the sustainable development and utilization of groundwater resources.
Association between Benton Visual Retention Test Scores and PET Imaging in Elderly Adults
Authors: Abe Misaki , Kimura Noriyuki , Sasaki Yuuki , Eguchi Atsuko , Matsubara Etsuro
Published: December 2021

Background:

The Benton Visual Retention Test (BVRT) is a well-validated and reliable
test for assessing visual memory and visuospatial function. However, the association between the
BVRT score and imaging biomarker of Alzheimer’s disease (AD) remains unclear.

Objective:

This study examined whether the BVRT score is associated with brain amyloid burden
and cortical glucose metabolism in elderly adults without dementia.

Methods:

A total of 69 elderly adults without dementia, including 45 subjects with amnestic mild
cognitive impairment and 24 cognitively healthy adults, underwent the BVRT and 11C-Pittsburgh
compound B (PiB) and 18F-fluorodeoxyglucose (FDG) positron emission tomography. The correct
scores in the BVRT were used for analyses. A multiple linear regression analysis was conducted to
investigate the relationship between BVRT scores and PiB or FDG uptake. Moreover, a voxel-wise
linear regression analysis of the association between BVRT scores and PiB or FDG uptake was conducted
using Statistical Parametric Mapping.

Results:

After adjusting for age, sex, education, and ApoE4 status, the BVRT scores were inversely
correlated with the mean PiB uptake (β = −0.35, P = 0.003), whereas they were positively correlated
with FDG uptake (β = 0.266, P = 0.038). Moreover, the BVRT scores were inversely correlated
with amyloid burden in the right superior temporal and superior frontal gyri and the left parietal
lobe, whereas they were positively correlated with cortical glucose metabolism in the right posterior
cingulate and milled temporal gyri, left temporoparietal lobe, and right superior frontal gyrus.

Conclusion:

BVRT scores are correlated with brain amyloid burden and cortical glucose
metabolism, mainly in regions commonly affected in AD.
In Silico Studies of Piperidine Derivatives as Protein Kinase B Inhibitors
through 3D-QSAR, Molecular Docking and Molecular Dynamics Simulation
Authors: Liu Sisi , Li Yaxin , Wang Jin , Rui Xue , Tian Haobo , Li Chenshuo , Guo Chunyan
Published: December 2021

Background:

Protein kinase B (Akt) is a serine/threonine-protein kinase that drives the diverse
physiological process. Akt is a promising therapeutic target, which involves cancer cell growth, survival,
proliferation and metabolism.

Objective:

The study aims to design highly active Akt inhibitors, and to elucidate the structural requirements
for their biological activity, we analyzed the key binding features and summarized the structural
determinants for their bioactivities.

Methods:

A series of piperidine derivatives have been investigated employing three-dimensional quantitative
structure-activity relationship (3D-QSAR), molecular docking and molecular dynamics simulation.

Results:

The statistics of the comparative molecular field analysis (CoMFA) model (Q2=0.631, R2=0.951)
and the comparative molecular similarity index analysis (CoMSIA) model (Q2=0.663, R2=0.966) indicated
that our 3D-QSAR model was accurate and reliable. Besides, the stability of receptor-ligand interactions
under physiological conditions was then evaluated by molecular dynamics simulation, in agreement
with the molecular docking results.

Conclusion:

Our study provided valuable insights for the discovery of potent Akt inhibitors.
Corrigendum to: Discussion on the paper “Combined Effects of Thermal Radiation and Magnetohydrodynamic on Peristaltic Flow of Nanofluids: Applications to Radiotherapy and Thermotherapy of Cancer” by Wahed Hasona et al.
Authors: Elogail Mostafa A.
Published: December 2021

A typographical error appeared in equation in the manuscript entitled “Discussion on the paper Combined Effects of Thermal
Radiation and Magnetohydrodynamic on Peristaltic Flow of Nanofluids: Applications to Radiotherapy and Thermotherapy of
Cancer” by Mostafa A. Elogail in “Current Cancer Therapy Reviews”, 2021; 17(2), 93-6.

We regret the error and apologize to the readers.

The original article can be found online at https://www.eurekaselect.com/189490/article
Association Analysis Between Introns and mRNAs in Caenorhabditis elegans
Genes with Different Expression Levels
Authors: Cao Yanjuan , Zhang Qiang , Yan Zuwei , Zhao Xiaoqing
Published: December 2021

Background:

Introns are ubiquitous in pre-mRNA but are often overlooked. They also play
an important role in the regulation of gene expression.

Objective and Method:

We mainly use the improved Smith-Waterman local alignment approach to
compare the optimal matching regions between introns and mRNA sequences in Caenorhabditis elegans
(C. elegans) genes with high and low expression.

Results:

We found that the relative matching frequency distributions of all genes lie exactly between
highly and lowly expressed genes, indicating that introns in highly and lowly expressed genes have different
biological functions. Highly expressed genes have higher matching strengths on mRNA sequences
than genes expressed at lower levels; the remarkably matched regions appear in UTR regions, particularly
in the 3'UTR. The optimal matching frequency distributions have obvious differences in functional
regions of the translation initiation and termination sites in highly and lowly expressed genes. The
mRNA sequences with CpG islands tend to have stronger relative matching frequency distributions, especially
in highly expressed genes. Additionally, the sequence characteristics of the optimal matched
segments are consistent with those of the miRNAs, and they are considered a type of functional RNA
segment.

Conclusion:

Introns in highly and lowly expressed genes contribute to the recognition translation initiation
sites and translation termination sites. Moreover, our results suggest that the potential matching relationships
between introns and mRNA sequences in highly and lowly expressed genes are significantly
different and indicate that the matching strength correlates with the ability of introns to enhance gene
expression.
Lactose and Casein Cause Changes on Biomarkers of Oxidative Damage and Dysbiosis in an Experimental Model of Multiple Sclerosis
Authors: Escribano Begoña M. , Muñoz-Jurado Ana , Luque Evelio , Conde Cristina , Feijóo Montse , LaTorre Manuel , Valdelvira Manuel E. , Buendía Paula , Giraldo Ana I. , Caballero-Villarraso Javier , Santamaría Abel , Agüera Eduardo , Túnez Isaac
Published: December 2021

Background and Objectives:

Experimental autoimmune encephalomyelitis (EAE) in rats closely reproduces multiple sclerosis (MS), a disease characterized by neuroinflammation and oxidative stress that also appears to extend to other organs and their compartments. The origin of MS is a matter for discussion, but it would seem that altering certain bacterial populations present in the gut may lead to a proinflammatory condition due to the bacterial lipopolysaccharides (LPS) in the so-called brain-gut axis. The casein and lactose in milk confer anti-inflammatory properties and immunomodulatory effects. The objectives of this study were to evaluate the effects of administration of casein and lactose on the oxidative damage and the clinical status caused by EAE and to verify whether both casein and lactose had any effect on the LPS and its transport protein -LBP-.

Methods:

Twenty male Dark Agouti rats were divided into control rats (control), EAE rats, and EAE rats, to which casein and lactose, EAE+casein, and EAE+lactose, respectively, were administered. Fifty-one days after casein and lactose administration, the rats were sacrificed, and different organs were studied (brain, spinal cord, blood, heart, liver, kidney, small, and large intestine). In the latter, products derived from oxidative stress were studied (lipid peroxides and carbonylated proteins) as well as the glutathione redox system, various inflammation factors (total nitrite, Nuclear Factor-kappa B p65, the Rat Tumour Necrosis Factor-α), and the LPS and LBP values.

Results and Conclusion:

Casein and lactose administration improved the clinical aspect of the disease at the same time as reducing inflammation and oxidative stress, exerting its action on the glutathione redox system, or increasing GPx levels.
Association between Structural Determinants of Health and Posttraumatic
Stress Symptoms during the COVID-19 Pandemic
Authors: Mahmoodi Zohreh , Koshesh Kian Javadi , Almasi Ghaffar , Pournajaf Safura , Rastad Hadith , Ghavidel Nooshin
Published: December 2021

Background:

Psychological problems, such as post-traumatic stress
symptoms (PTSS), are among the most important complications associated with
the COVID-19 pandemic in people. Studying the social determinants of health (SDH)
and its impact on the populations during the crisis will help governments
deal better with health emergencies so that every person can have an equal opportunity
to stay healthy.

Objective:

To determine what factors affect PTSS, we conducted a study to investigate
the association between structural determinants of health and PTSS during
the COVID-19 pandemic.

Methods:

We conducted a cross-sectional study on 370 people referred to a selected
laboratory between June and July 2020 in Karaj province, Iran. Post-traumatic
stress disorder (PTSD) 8-item inventory was used to evaluate the PTSS
and its subscales, including intrusion, avoidance, and hypervigilance in the participants.

Results:

Overall, 51.2% of participants were male, and 17.3% were positive for
the IgM or IgG COVID-19 test. The most common symptoms in these patients
were weakness, myalgia, cough, anosmia, and fever. The prevalence of total
PTSS, intrusion, avoidance, and hypervigilance symptoms were 7.1%, 25.7%,
41.6%, and 16.2%, respectively. In univariable regression analysis, female gender
(p-value=0.01, 95%CI (2.25-0.31)), un-employment (p-value=0.011, 95%CI
(0.37-2.81)), having symptoms of COVID-19 disease (p-value=0.000, 95%CI
(.82-2.75)), underlying chronic disease, were directly associated with PTSS.

Conclusion:

Results showed that sex and occupation as structural determinants
of health could affect PTSS in the COVID-19 pandemic. However, in the multivariable
model, having symptoms of the COVID-19 disease and underlying disease
affected PTSS.
A Comprehensive Insight on Self Emulsifying Drug Delivery Systems
Authors: Nanda Arun , Kadian Renu
Published: December 2021

Background:

The oral route is a highly recommended route for the delivery of a drug. But
most lipophilic drugs are difficult to deliver via this route due to their low aqueous solubility. Selfemulsifying
drug delivery systems (SEDDS) have emerged as a potential approach of increasing dissolution
of a hydrophobic drug due to spontaneous dispersion in micron or nano sized globules in the
GI tract under mild agitation.

Objective:

The main motive of this review article is to describe the mechanisms, advantages, disadvantages,
factors affecting, effects of excipients, possible mechanisms of enhancing bioavailability,
and evaluation of self-emulsifying drug delivery systems.

Result:

Self emulsifying systems incorporate the hydrophobic drug inside the oil globules, and a
monolayer is formed by surfactants to provide the low interfacial tension, which leads to improvement
in the dissolution rate of hydrophobic drugs. The globule size of self-emulsifying systems depends
upon the type and ratio of excipients in which they are used. The ternary phase diagram is constructed
to find out the range of concentration of excipients used. This review article also presents recent and
updated patents on self-emulsifying drug delivery systems. Self-emulsifying systems have the ability
to enhance the oral bioavailability and solubility of lipophilic drugs.

Conclusion:

This technique offers further advantages such as bypassing the first pass metabolism via
absorption of drugs through the lymphatic system, easy manufacturing, reducing enzymatic hydrolysis,
inter and intra subject variability, and food effects.
Generic structure of descriptive text written English language learner and teachers
Authors: Sipayung Kammer Tuahman , Tampubolon Sahlan , Napitupulu Fenty Debora , Tobing Febrina Lumban
Published: December 2021

The objective of this research is to describe the appropriateness and inappropriateness of participants in formulating identification in descriptive text. The researcher applies the theory of Gerot and Wignel (1994) from the perspective of systemic functional linguistics. To achieve the aim of this research, the researcher used a descriptive qualitative research design. The participants of this research come from three different groups (students at junior high school, English department students, and English teachers). It was chosen since the whole group is familiar with this kind of genre. Since the pandemic situation, the researcher used WhatsUp as a supporting instrument to collect the data. After analyzing the data (interactive data analysis) through the implementation of the systemic functional linguistics perspective, the researcher got the result. This research shows that 50% of junior high school students categorized appropriately in writing identification, 20% of English department students categorized appropriately, and 60% of English teachers categorized appropriately. Based on the results above, it can be concluded that the participants have a poor ability to write identification. It suggests that the English teachers' training program and English teachers have a better pedagogical plan and knowledge of the genre before teaching descriptive text.
role and importance of the digital economy in the development of innovative
Authors: Narmanov Ulugbek
Published: December 2021

The research reveals that theoretical foundations, stages, driving forces, efficiency factors of modern digitalization are considered as digital economy. The key components of the term “digital economy” are presented: digital technologies, ecosystems and transformations, taking into account their interconnection and interdependence, as well as continuity with the previously developed conceptual series - informatization, intellectualization and robotization. Also, the article presents a clear understanding of the object and subject of research, the importance of the essence of the digital economy phenomenon and the stages of its development. The purpose of this study is to study the relationship between digital technologies, innovative and economic development, describe the advantages and disadvantages of digitalization for countries with different levels of economic development. It is noted that the digital economy is an integral part of the information (digital) environment, forming in accordance with the needs of the real sector of the economy and the needs of society, changing under the influence of technological innovations.
Adolesanlarda Sağlık Denetim Odağı ile Sağlık Davranışları Arasındaki İlişki: Kesitsel Bir Çalışma
Authors: KARA ALKIR Yeliz , İLHAN Nesrin
Published: December 2021

Amaç: Bu araştırma adolesanlarda sağlık denetim odağı ile sağlık davranışları arasındaki ilişkinin belirlenmesi amacıyla gerçekleştirildi. Yöntem: Bu kesitsel araştırma İstanbul’da bir devlet lisesinde öğrenim gören 1111 adolesan ile gerçekleştirildi. Veriler sosyodemografik özellikler bilgi formu, Adolesan Yaşam Biçimi Ölçeği II (AYB II) ve Sağlık Denetim Odağı (SDO) Ölçeği kullanılarak toplandı. Verilerin analizinde tanımlayıcı istatistikler, Student-t testi, tek yönlü varyans analizi(ANOVA), Pearson korelasyon analizi ve Hiyerarşik çoklu regresyon analizi kullanıldı. Bulgular: Adolesanların yaş ortalaması 15,75±1,03 yıl olup, %58,2’si kızdır. AYB II ölçeği toplam puan ortalaması 118,77±18,17 bulundu. Regresyon analizinde cinsiyet, aile tipi, okul dışı bir işte çalışma durumu, aile ekonomik durumu, aile ile ilişkiler, arkadaşlar ile ilişkiler sosyal aktivitelere katılma, sağlığını değerlendirme durumu, günlük aktiviteleri kısıtlayan engel durumu, iç SDO ve dış SDO puanları AYB II toplam puanı ile anlamlı olarak ilişkili bulundu (R²=0,253,p<0,001). Sonuç: Araştırma sonucunda adolesanların sağlık davranışlarının orta düzeyde olduğu belirlendi. İç SDO ve dış SDO puanı arttıkça AYB II toplam puanı artmaktadır. Erkek olmak, çekirdek aile yapısında olmak, sosyal aktivitelere katılmak ve ekonomik durumun artması AYB II toplam puanını arttırmaktadır. Okul dışı bir işte çalışmak günlük aktiviteleri kısıtlayan engel durumunun olması AYB II toplam puanını azaltmaktadır. Aile ve arkadaşlar ile ilişkiler iyileştikçe, sağlığını olumlu yönde değerlendirme düzeyi arttıkça AYB II toplam puanı artmaktadır.
Valuation of Mangrove Direct Benefit in Jerowaru District, East Lombok Regency, West Nusa Tenggara
Authors:   Geography Education Study Program, Muhammadiyah University of Mataram, Indonesia, Johari Harry Irawan ,   Master of Environmental Science, Muhammadiyah University of Mataram, Indonesia, Sukuryadi Sukuryadi , Ibrahim Ibrahim ,   Geography Education Study Program, Muhammadiyah University of Mataram, Indonesia,   Master of Environmental Science, Muhammadiyah University of Mataram, Indonesia, Adiansyah Joni Safaat ,   Master of Environmental Science, Muhammadiyah University of Mataram, Indonesia
Published: December 2021

Mangroves have various functions and roles, both economic and ecological. In Jerowaru District, East Lombok Regency, the function and role of mangroves are economically and ecologically beneficial, but their value has not been measured. This study aims to determine the valuation of direct benefits of mangroves in Jerowaru District, East Lombok Regency. The approach taken in determining the economic value of mangrove products and services is financial analysis and economic analysis. In financial analysis, a direct approach is used, namely by using market values for marketed commodities and determining the value of substitutes for goods and services that are not marketed. While in the economic analysis, the shadow price or accounting price, namely the value adjusted in such a way as to describe the true value of mangrove goods and services. The results showed that the value of the direct benefit of mangroves in the study area was ± IDR 88.162.750/ha/year. Valuation of the value of direct benefits of mangroves at the location comes from mangrove products and services in the form of firewood and charcoal products, construction wood, capture fisheries products, fish and shrimp larvae stocks, wildlife, preservatives and dyes, food ingredients, and medicines, animal feed, salt, recreation, and tourism, as well as education and research.