bluuebunny/crossref_metadata_2025 huggingface dataset:
Kontribusi Kecerdasan Emosional terhadap Konflik Persahabatan pada Siswa SMP Negeri 1 Puding Besar, Bangka
Authors: Nitary Gian , Komarudin Komarudin
Published: April 2023

Characteristics of friendships are spending time together, interacting in diverse contexts, distancing others from the relationship, and offering emotional support to one another. But in friendship there are often conflicts. Conflict is a social phenomenon that can happen to anyone and anywhere. To resolve conflicts and disputes that occur with friends, teenagers are required to be able to control their emotions. Adolescents who are able to reduce and control emotions can be seen from the emotional intelligence of adolescents. Correct emotional balance, satisfaction classification, and mood regulation are all possible with emotional intelligence. This study uses a quantitative research methodology. In this study, the quantitative method was applied with a correlational approach. This research was conducted at SMP Negeri 1 Puding Besar with a population of 350 students, but the researchers took a sample of 50 students. The sampling technique is purposive sampling. Data retrieval by filling in the scale. Data analysis using Pearson Correlation Product Moment. The results of this study found that the contribution of emotional intelligence to friendly conflict obtained a significant level < 0.001 < 0.05 with a correlation coefficient of 0.494, meaning that emotional intelligence has a correlation with friendly conflict. The contribution of emotional intelligence to friendly conflict is a negative relationship, so it can be assumed that the higher the emotional intelligence, the lower the friendship conflict.

Keywords: Emotional Intelligence, Friendship Conflict
A Descriptive Study of Digital Stress among Employees Who Adopt a Hybrid Working System at PT.XYZ
Authors: Angesti Nadya Ganis , Azalia Audry Belda , Sebastian Meidelinne , Wijaya Natasha , Lie Daniel , Pribadi Roland Bonggo
Published: April 2023

One consequence of pandemic COVID-19 was that most companies implemented a hybrid working system (a mixture of work from home and office). During this period, employees at PT. XYZ who adopted the hybrid working system, experienced stress that caused by the usage of massive information and communication technology, that resulted in psychological detrimental effects. The objective of this study was to investigate the level and the types of digital stresses that faced by those employees. This research took place in March 2022, used a quantitative, online survey-based questionnaire named Digital Stressors Scale (α = 0.865) consisted of 50 questions with seven-points Likert Scale and convenient sampling technique, involving 107 employees of PT. XYZ as the participants. Data were then analyzed using descriptive statistics with the help of SPSS software. Result suggested that overall employees faced a high level of digital stress and the highest mean among the 10 dimensions of digital stress was invasion (M = 4.18, SD = 1.47 - stress about the tendency harming their individual personal data). The result is expected to help the management to think of various solutions to curb the problems as to improve the well-being of the employees working at PT. XYZ.
Social and Political Corruption in Chinua Achebe's Things Fall Apart (1958): A Critical Study
Authors: Bani-Khair Baker Mohammad Jamil , Al Ahmad Mohamad Helmi , AbdulKarim Majed , Alkhazaleh Mahmoud
Published: April 2023

This paper studies the idea of the social and political corruption in Chinua Achebe's Things Fall Apart (1958) from a critical view point. It focuses on Okonkow's characterization levels, and highlights the ontological, individualistic, political, and social aspects of the main character's aspects. Achebe's novel is a rich example of the social and political corruption of the tribal system that is built on myths, tribal mentality and physical prowess. Such a masterpiece by the Nigerian Novelist, China Achebe, serves as an authentic representation of a particular time period and setting when Nigeria was under colonial oppression. It is thematically and stylistically rich in colonial accounts of Africa in terms of language use, traditional African lore, and cultural history.
Tort Law and its Effects on Modern Chinese Society
Authors: Lin Ronald Joseph
Published: April 2023

This paper takes a detailed look at the tort principles used in China and compares them to their American counterparts. The emergence of the Tort Liability Law of the People’s Republic of China, which went into effect in July 2010, has been an important and necessary milestone in China’s legal development, especially in the area of civil law. China is a land defined by many cultural, historical and societal constructs that vary immensely from its Western counterparts, and much of these differences have woven itself into the creation, evolution and practical applications of its legal principles and doctrines. The new tort law will undoubtedly have a lasting impact on Chinese society and invariably influence the way Chinese citizens behave in everyday life, as extra emphasis and clarification will be placed on their societal duties and legal liabilities owed towards fellow citizens.
Representaciones sociales de estudiantes de administración y profesionales de reclutamiento de Chihuahua
Authors: Escobedo Portillo Alberto , Fierro Murga Luz Ernestina , Mancera Valencia Federico Julián
Published: April 2023

La educación superior, como etapa previa a la inclusión al entorno laboral, no solo es determinante de la formación de profesionistas, sino también es factor decisivo de la manera en que los jóvenes perciben el ambiente de trabajo y cómo son vistos por las empresas. El estudio se enfoca en identificar las representaciones sociales de los estudiantes de último semestre, de carreras administrativas, de cuatro universidades; dos públicas y dos privadas, para contrastarlas con las de reclutadores del sector público y privado. Se trata de un estudio explicativo-comprensivo, cualitativo, documental y de campo, basado en técnicas como la encuesta y el análisis de información escrita. Se identificaron los discursos que predominan entre estudiantes con relación a docentes, autoridades, personal administrativo, así como los relacionados con jóvenes de otras instituciones de educación superior, entre otros elementos, a la vez que se contrastan los calificadores con aquellos que tienen los profesionales de recursos humanos que reclutan, con base en su experiencia. La evidencia que subyace en los resultados de este estudio debe de traducirse en estrategias y acciones institucionales, por lo que se recomienda replicar este tipo de estudios para el cumplimiento de perfiles de egreso.
An Artificial Intelligence Algorithm to Optimize the Classification of the Hepatitis Type
Authors: Hathal Khalil Hiba , Manfi Rada Sabah
Published: April 2023

Hepatitis is one of the diseases that has become more developed in recent years in terms of the high number of infections. Hepatitis causes inflammation that destroys liver cells, and it occurs as a result of viruses, bacteria, blood transfusions, and others. There are five types of hepatitis viruses, which are (A, B, C, D, E) according to their severity. The disease varies by type. Accurate and early diagnosis is the best way to prevent disease, as it allows infected people to take preventive steps so that they do not transmit the difference to other people, and diagnosis using artificial intelligence gives an accurate and rapid diagnostic result. Where the analytical method of the data relied on the radial basis network to diagnose the disease, in addition to using the classification of the regression tree as well as the use of the genetic algorithm to improve the classification accuracy of both methods and by comparing the methods used to find out the most efficient methods of classification through criteria. Classification error, mean square root error, and average absolute relative error, and concluded that the experimental results are that the methods are good in terms of classification, as they gave results with less classification of error, and that the radial basis network was superior to the classification regression tree, and that the addition of the genetic algorithm led to an improvement classification accuracy.

Paper type: Research paper.
Comparison of Some Methods for Estimating Nonparametric Binary Logistic Regression
Authors: Bassem Khalaf Narjes , Ali Mohammed Lekaa
Published: April 2023

In this research, the methods of Kernel estimator (nonparametric density estimator) were relied upon in estimating the two-response logistic regression, where the comparison was used between the method of Nadaraya-Watson and the method of Local Scoring algorithm, and optimal Smoothing parameter λ was estimated by the methods of Cross-validation and generalized Cross-validation, bandwidth optimal λ has a clear effect in the estimation process. It also has a key role in smoothing the curve as it approaches the real curve, and the goal of using the Kernel estimator is to modify the observations so that we can obtain estimators with characteristics close to the properties of real parameters, and based on medical data for patients with chronic lymphocytic leukemia and through the use of the Gaussian function and based on the comparison criterion (MSE) it was found that the Nadaraya -Watson method is the best because it obtained the lowest value for this criterion.
ESTRATEGIA DE CERTIFICACIÓN DE BIOCOMBUSTIBLES PARA EL SECTOR ENERGÉTICO EN MÉXICO
Authors: Santos Equihua Yéssica Yasmín
Published: April 2023

El objetivo del presente trabajo consiste en conocer los diferentes esquemas de certificaciones de biocombustibles, como una estrategia de negocios en el sector energético, para lo cual se examinan a detalle los principales esquemas en torno a la producción de biocombustibles, se identifican los aspectos positivos y negativos en cada una de las normas establecidas y; además, se describen las principales barreras o incentivos que tienen los productores de biodiesel para acceder a la certificación. En conclusión, las certificaciones son un instrumento que ayuda a diferenciar los productos sustentables de los no sustentables en el mercado de los biocombustibles, beneficiando tanto a productores como a consumidores y; al mismo tiem­po, son un incentivo para esta industria como fuente de energía alternati­va, para finalmente hacer sugerencias específicas para mejorar el proceso de certificación de biocombustibles en México.
CÓDIGOS DE RESPONSABILIDAD SOCIAL CORPORATIVA EN LAS EMPRESAS EN COLIMA: MEDIDAS Y PRÁCTICAS DEL COMPORTAMIENTO.
Authors: Soto Ramírez Francisco Carlos , Santarriaga Pineda María de los Dolores
Published: April 2023

Los “códigos de responsabilidad social corporativa”; constituyen la base so­bre la cual los miembros de una organización toman decisiones y resuelven problemas éticos. Además de ser reconocidos como un elemento clave en la reputación de la organización dan credibilidad ante la opinión pública. El presente estudio tiene como objetivo examinar las medidas y prácticas que empresas que operan en Colima han puesto en marcha para comunicar el “ethos” de los CRSC, y determinar si las variables uso, consecuencias, rela­ción con stakeholders y comunicación están asociados positivamente con la impresión de la efectividad del CRSC de cada organización. Se aplicó un cuestionario auto-administrado a los Gerentes generales o directores de las empresas; la muestra fue de 150 empresas. Los resultados demuestran que las variables consecuencias por quebranto, relación con stakeholders y comunicación del código y capacitación son predictoras de la percepción favorable de la efectividad del CRSC.
Foreldraútilokun, reynsla útsettra foreldra í Tyrklandi
Authors: Torun Fuat , Matthewson Mandy , Torun Sebahat Dilek
Published: April 2023

Markmið rannsóknarinnar var að kanna reynslu útsettra foreldra í Tyrklandi af þeim útilokandi aðferðum sem notaðar voru til að útiloka þá frá barni sínu. Rannsóknin kannaði einnig skoðanir útsettra foreldra á þeirri þjónustu sem þeir fengu hjá fagaðilum innan geðheilbrigðisþjónustu og hjá lögfræðingum meðan á aðskilnaði fjölskyldunnar stóð. Áttatíu og fjórir útsettir foreldrar tóku þátt í og luku við netkönnun. Könnunin fólst í spurningum varðandi félags- og lýðfræðilegar upplýsingar, spurningum varðandi reynslu útsettra foreldra sem rannsakendur sjálfir mótuðu og spurningum um 13 útilokandi aðferðir sem lýst hefur verið í fræðunum. Meirihluti þátttakenda voru karlkyns (94%) og meðalaldur þeirra var 42 ár. Þátttakendur greindu frá því að hafa sætt margvíslegum aðferðum útilokunar og næstum helmingur þeirra hafði ekki hitt barnið sitt, þrátt fyrir að dómsúrskurður um umgengni lægi fyrir. Helmingi þátttakenda hafði verið vísað til fagaðila innan geðheilbrigðisþjónustu meðan á skilnaðarferlinu stóð og flestir voru þessir þátttakendur þeirrar skoðunar að fagaðilarnir hefðu ekki nægilega þekkingu á foreldraútilokun. Að sama skapi var skoðun flestra þátttakenda sú að þeir lögfræðingar sem þeir áttu í samskiptum við, hafi ekki haft nægilega þekkingu á foreldraútilokun. Þátttakendur sögðust einnig hafa upplifað vonleysi, örvæntingu, einmanaleika, kvíða og ekki getað notið lífsins. Þessar niðurstöður eru í samræmi við rannsóknir gerðar á þátttakendum frá öðrum löndum.
Contributos dos enfermeiros de reabilitação num serviço de medicina interna
Authors: Venâncio Sara Soares
Published: April 2023

Com o envelhecimento da população portuguesa, o aumento das patologias chamadas crónicas e o maior grau de dependência dos clientes, torna-se imprescindível a alocação de Enfermeiros Especialistas em Reabilitação (EEER) nos serviços de Medicina Interna. Desta forma, é também importante a avaliação da sua presença, para que se possa realizar um planeamento das intervenções.
É neste contexto que surge esta investigação; trata-se de um estudo quantitativo, transversal e retrospetivo realizado num serviço de medicina de um hospital da região norte de Portugal e tem como principal objetivo descrever a atividade de enfermagem de reabilitação, de forma a fomentar o espírito de autocrítica, permitindo um melhor planeamento da prestação de cuidados especializados.
Durante o período compreendido entre 1 de janeiro de 2019 e 31 de dezembro de 2020 deram entrada no serviço em causa 1786 clientes; destes, 882 tiveram implementados planos de enfermagem de reabilitação. Foram realizadas 4130 intervenções, sendo que as mais frequentes foram “cinesioterapia respiratória” e “fortalecimento muscular”. Também se optou por comparar a produtividade dos dois anos uma vez que o número de recursos humanos foi diferente tendo-se concluído que durante o ano 2020 conseguiu-se alcançar mais 236 clientes do que no ano anterior o que permite inferir que a resposta pode ser melhorada alocando mais enfermeiros de reabilitação ao serviço. Sugere-se que sejam implementados programas específicos para as patologias mais frequentes (doenças e perturbações do aparelho respiratório e do aparelho circulatório) e que sejam realizados estudos randomizados que permitam comprovar a eficácia dos programas de reabilitação.
Intervenção do Enfermeiro Especialista em Reabilitação em Mulheres com Incontinência Urinária, após o AVC
Authors: Braga Marta , Ferreira Salomé , Morais Carminda , Chiado Andreia , Lima Andreia
Published: April 2023

Introdução: A incontinência urinária tem uma grande prevalência em utentes com AVC. O tratamento conservador é o mais recomendado, pois envolve menor custo financeiro e menos efeitos colaterais. Este estudo objetiva: Avaliar o efeito de um Programa de Reabilitação na Gestão da Incontinência Urinária na mulher após a ocorrência do AVC.
Metodologia: Trata-se de um Estudo de Casos Múltiplos, de método quantitativo. A amostra foi constituída por (n=5) mulheres com idade entre 53 e 87 anos. Foi aplicado um programa de reabilitação desde a deteção da incontinência urinária, até ao momento da alta. Os instrumentos utilizados foram: Escala de Autoeficácia de Broome e Diário Miccional.
Resultados: Este estudo permitiu concluir que as utentes que inicialmente apresentavam urgência e perdas de urina, deixaram de ter. Nos scores da escala de autoeficácia de Broome: na 1ª avaliação, na parte A e B todas apresentaram baixa autoeficácia, exceto o Caso 8 que na parte B obteve autoeficácia moderada. Na 2ª avaliação todas obtiveram elevada autoeficácia.
Discussão: Quando se compara o pré e pós do programa, verifica-se que todas obtiveram resultados positivos em relação à urgência urinária, perdas de urina, assim como ao nível de confiança na realização das contrações dos músculos pélvicos, sem que ocorram perdas de urina.
Conclusão: O programa de reabilitação para a gestão da incontinência urinária, teve um efeito positivo em todas as utentes do estudo.
Các yếu tố quyết định nhu cầu tín dụng và khả năng tiếp cận các nguồn tín dụng chính thức của nông hộ: Nghiên cứu ở tỉnh Hòa Bình, Việt Nam
Authors: Nguyễn Thế Kiên
Published: April 2023

Bài viết nghiên cứu các yếu tố quyết định đến nhu cầu tín dụng và quyết định vay vốn từ các tổ chức tín dụng chính thức của nông hộ tại tỉnh Hòa Bình. Chúng tôi tập trung vào sáu đặc điểm nội tại chính mà các tổ chức tín dụng có thể kiểm soát bao gồm lãi suất, yêu cầu tín dụng, quy trình cho vay, chất lượng dịch vụ, thời gian ân hạn và khoảng cách. Sử dụng phương pháp PLS-SEM phân tích dữ liệu thu thập từ 389 nông hộ tại Hòa Bình, kết quả cho thấy lãi suất không làm thay đổi nhu cầu tín dụng nhưng có thể làm giảm ý định vay vốn của hộ nông nghiệp. Bên cạnh đó, các yêu cầu tín dụng thường không có tác động đến cả nhu cầu tín dụng và quyết định của hộ gia đình trong khi chất lượng dịch vụ và thời gian ân hạn luôn có tác động tích cực đến nhu cầu tín dụng và quyết định vay vốn. Kết quả nghiên cứu này giúp các tổ chức tín dụng chính thức có các chính sách để thu hút khách hàng nông hộ.
A Case of Reconstruction of Large Defect in Posterior Wall of Bony External Auditory Canal Using Cavum Conchal Cartilage
Authors: Sim Soohyun , Jang Junhyuk , Park Sung Yool , Heo Kyung Wook
Published: April 2023

External auditory canal (EAC) wall defect may occur due to cholesteatoma, and surgeries for chronic ear diseases, trauma, neoplasm or idiopathic. Conservative treatment is available if the severity of the symptom is mild or asymptomatic. However, these defects require repairment not only to attain relief from intermittent otologic symptoms but also to prevent retraction pockets and sequential cholesteatoma. There have been no reported cases of reconstruction of EAC wall defect by cartilage with perichondrium and groove of wall defect by drilling. We manipulated the conchal cartilage so that it could effectively provide robust reconstruction of the canal wall defect. Herein we report a case of EAC reconstruction with mastoidectomy with no further complications.
Parental Awareness of the National Support Policy for Outpatient Clinic Newborn Hearing Screening in South Korea
Authors: Kim Jisu , Park Su-Kyoung , Choi Kyu Young , Chang Jiwon
Published: April 2023

Background and Objectives Newborn hearing screening (NHS) is recommended for babies before reaching the age of one month; however, the awareness of the policy in parents is reported to be insufficient in South Korea. The understanding that NHS is covered by the national insurance is also low possibly due to the lack of both advertisement and national policies for hearing loss. In this study, parental awareness of NHS and related national support policies were investigated by surveying parents who visited the Otolaryngology clinic for NHS for their children.Subjects and Method Parental awareness was evaluated by a survey of 99 parents for the suitable period for NHS and hearing evaluation for their children. Also, we investigated the awareness of national support policies for NHS and hearing aids, along with other opinions regarding the national support system.Results The recommended initial NHS timing was acknowledged by 84.7% of the parents; however, the recommended confirmatory hearing test timing was recognized only by 17.2%. The awareness of national support policies for hearing aids, support policies for inpatient and outpatient NHS was noted in 37.4%, 46.5%, and 37.4%, respectively. The necessity for national guidance and a national management system for neonatal hearing loss was supported by 92.9% and 97% of the parents, respectively.Conclusion Most parents visiting the Otolaryngology clinic were unaware of the time point for the confirmatory hearing test and of the national support policies for infantile hearing loss. A national infantile hearing management system is required to meet the 1-3-6 guidelines for infantile hearing loss.
How did the COVID-19 Lockdown Affect Hispanic University Students’ Daily Life?
Authors: Wang Hongwei , Mohebujjaman Muhammad , Quintana Fernando G , Villarreal Melissa
Published: April 2023

Objective: COVID-19 has changed dramatically, including the schedules of university students. We wanted to see what and how have been changed. Methods: We designed a questionnaire including multiple choice questions and fill in questions about student well-being before and during the COVID-19 lockdown to students at Texas A&M International University located in South Texas and analyzed the changes we observed in their daily food intake, physical activity, and sleep patterns. The questionnaire also included demographic questions. 393 students were sent the questionnaire in total. After cleaned the outlier, 387 entries were kept for data analysis. Results: Our results indicate that the COVID-19 lockdown decreased the time that students spent on physical activities and sleep per week. By contrast, we found no association between lockdown and body mass index (BMI) changes. Conclusion: Our results suggest that local university needs to provide free fitness classes and events to encourage student’ physical activity. The university can also host free workshops to guide students toward healthier sleep patterns. Cafeteria department on campus should design healthy meal plans so students are given the option of a more balanced daily dietary intake.
Inhibitory Effect of Agrocybe Chaxingu (Chaxines) on RANKL-Induced Osteoclast Differentiation in RAW246.7 Cells: Possible Prevention of Osteoporosis
Authors: Konno Sensuke , Elyaguov Jason , Dixon Ashley , Choudhury Muhammad
Published: April 2023

Objectives: Receptor-activator of nuclear factor-κB ligand (RANKL) is an essential stimulating factor for inducing osteoclast differentiation, feasibly resulting in osteoporosis. The bioactive extract of Agrocybe chaxingu mushroom, CHX, has been shown to have osteoclastic inhibitory activity. Accordingly, we investigated if CHX would inhibit or disrupt RANKL-induced osteoclast differentiation, implying possible prevention of osteoporosis. Materials and Methods: Monocyte/macrophage RAW264.7 cells (RAW cells) were employed as our experimental model and treated with varying concentrations of RANKL alone or with CHX for 5 days. Formation of osteoclasts was then assessed using tartrateresistant acid phosphatase (TRAP) assay, counting stained cells as osteoclasts under a light microscope. The inhibitory mechanism of CHX was also explored by examining the RANKLmediated signaling pathways, oxidative stress (OXS), antioxidant enzymes, and apoptosis. Results: RANKL (100 ng/mL)-induced osteoclast differentiation in RAW cells was significantly (~20%) inhibited with 10 μg/mL of CHX. This was accompanied by the downregulation of two key signaling pathways and activation of antioxidant enzymes that likely led to the reduction in OXS. Moreover, CHX ultimately induced undifferentiated or RANKLunresponsive cells to apoptosis, indicated by the modulation of apoptotic regulators. These findings may then account for a disruption of osteoclast differentiation with CHX. Conclusion: CHX appears to have the inhibitory effect on RANKL-induced osteoclast differentiation in RAW cells. It is thus plausible that CHX may have potential clinical implications in osteoclast-mediated bone diseases/disorders, including osteoporosis.
Xanthogranulomatous Pyelonephritis, a Great Imitator: Case Report
Authors: Boada Adolfo , Plaza Stephanie , Nervi Renzo
Published: April 2023

Xanthogranulomatous pyelonephritis (XPN) is an atypical form of chronic pyelonephritis, characterized by the destruction of the renal parenchyma and its replacement with a chronic infiltrate of lipid-laden macrophages [1]. The clinical presentation is nonspecific and variable. Consider clear cell carcinoma, sarcomatoid renal cell carcinoma, renal tuberculosis, renal lymphoma, renal or psoas abscess, actinomycosis, renal cystic disease, and emphysematous pyelonephritis [2,3]. We present the case of a 59-year-old female patient, with a history of recurrent urinary tract infections, who came to our center due to severe anemia (5gr/dl), weight loss of 10 kg in 2 months, night sweats and weakness, concomitant sudden-onset lumbar pain and hematuria, after multiple studies, a diagnosis of PNX was made, which was confirmed by anatomopathological study.
Under the Weather: A Survey Study Done on Weather and Pain in a Back Pain Clinic
Authors: Li Keqing , Rutkowski Pawel , Yang William , Berkower Elanit , Berkower DO David
Published: April 2023

Many believe that bad weather exacerbates pain. Research results have shown inconsistent results until a large study, “Cloudy with a chance of pain,” was done using the help of a mobile app. This study discovered a similar relationship between weather and pain in a different climate and lower back pain patients. Furthermore, we have seen a residual effect post-weather. We suspect that the patient’s mental status affects weather rather than the compartment of body parts. We recommend the integration of cognitive-behavioral therapy (CBT) and serotonin-norepinephrine reuptake inhibitor (SNRI) into chronic pain management.
A Critical Survey of the Meaning of National Health to Nigeria’s College Students
Authors: F.A Obafemi , T.O Obaoghe , M.C Aruwa , R.I Irughe , E.O Okediji , P.T Zamani , D.I Ezekiel , C.O Ofoche , O.A Akinseesin , G.E Obi , J.U Onwude , J.O Olla , O.G Amosu , A.O Shokoya
Published: April 2023

The aim of this study was to find out the level of understanding of the concept of health to the Nigerian youth. The participants of this study were college students drawn from randomly selected communities in Cross River, Edo, and Kaduna States in Nigeria. A total of 140 participants were enlisted in the current study. Data were obtained with the aid of structured pretested questionnaires. The questionnaire was divided into sections and elicited information on the participants’ understanding of health, what it means to have a healthy Nigeria, and their role in making a healthy Nigeria. Defining what health meant to them, the majority of participants (50%) defined health as “a state of being mentally and physically balanced. A period of balance where there is no displacement in any functioning of the body”. The majority of the respondents (n=112, 80%) indicated that Nigeria is not healthy while 20% (n=28) indicated otherwise. Ascertaining if participants have a role in the health of Nigeria, the result indicated that the majority of the respondents (90%, n= 126) were of the opinion that they have a role to play in improving the health of Nigeria. Participants in the current study appear to be ready for a shift in the nature and systems of development around them, according to the findings. They had a clear understanding of what health was and what it meant to be in a healthy state and based on their response to the country's current state of health, it is clear that they require change, which is reflected in their belief that they have a role to play in the country's health and development.
Knowledge, Attitude and Performance of Physical Exercise among Pregnant Women Attending the Antenatal Clinic at Federal Medical Centre Asaba, Nigeria
Authors: Godsday Ogbutor Udoji , Sumaila Adijat Victoria , Chukwuemeka Ephraim , Adebowale Temitope , Deborah Akinyemi , Emmanuel Ezunu , Maria Nworah Awele , Kingsley Nwangwa Eze
Published: April 2023

Background: There is currently an increased global interest amongst researchers on the safety and effects of physical exercise for pregnant women. Both national and international committees for its overall health benefits promote regular exercise. The American Congress of Obstetricians and Gynecologists, recommends that pregnant women can exercise moderately for 30 mins on most days of the week. This study aimed to assess the knowledge, attitude, and practice of pregnant women to antenatal exercises at Federal Medical Centre Asaba, Nigeria, 2022. Methodology: A hospital-based cross-sectional study was conducted among 200 pregnant women. A systematic random sampling technique was used to select the study participants. Data were obtained on demographic and maternal characteristics, knowledge, attitude, and practice of pregnant women to antenatal exercises through a structured questionnaire. The data was subsequently analyzed using statistical package of social science version 20 (SPSS 20). Frequency and percentage were used to summarize the data and chi statistical test was used to test significant association at a p-value of <0.05. Results: A total of 200 pregnant women were recruited for this study. It was found that 53%, 44% and 10% had adequate knowledge, a positive attitude, and good practice respectively of antenatal exercises. Prevention of back pain (93%), ability to cope with delivery (87%) and excess weight gain (90%) were perceived as benefits, while difficulty in breathing (55.7%), abdominal pain (52.6%), severe back pain (29.9%) and headache (52.6%) were considered as contraindications to antenatal exercises. Walking (74%), relaxation (30%), and breathing exercise (25%) were the most practiced antenatal exercises, while pelvic floor (8%) and abdominal strengthening exercises (9%) were poorly practiced. There was a significant association between age group, BMI, trimester, number of children, level of education and the participants’ knowledge, attitude, and practice towards antenatal exercises (P<0.05). There was a significant association between the level of knowledge and attitude (P<0.05) but an insignificant association with their practice level to antenatal exercises (P>0.05). Conclusion: This study shows that pregnant women demonstrated a good knowledge and positive attitude but had poor practice level towards antenatal exercises. Regular exercise programs should be incorporated by physiotherapists and healthcare professionals into antenatal classes that is safe for both mother and neonate.
Excitatory aminoacids and epileptic seizures in immature brain
Authors: Mareš P , Folbergrová J , Kubová H
Published: April 2023

Data on convulsant and anticonvulsant action of drugs influencing excitatory amino acid receptors in developing rats are reviewed. Agonists of NMDA type of receptors NMDA and homocysteic acid, elicited an age-related seizure pattern--flexion, emprosthotonic seizures--in the first three postnatal weeks of rats. Generalized clonic-tonic seizures appeared only after a longer latency. Kainic acid administration resulted in epileptic automatisms and later in minimal, clonic seizures followed by generalized tonic-clonic seizures. A decrease of sensitivity to convulsant action with age is a general rule for all agonists tested. Different anticonvulsant action of NMDA and nonNMDA antagonists was demonstrated in a model of generalized tonic-clonic seizures induced by pentetrazol, whereas their action against epileptic afterdischarges elicited by electrical stimulation of cerebral cortex was similar. Again, higher efficacy in younger animals was a rule. As far as metabotropic glutamate receptors are concerned, agonists of groups II and III were shown to protect against convulsant action of homocysteic acid in immature rats and an antagonist of group I receptors MPEP suppressed the tonic phase of generalized tonic-clonic seizures induced by pentetrazol more efficiently in younger than in more mature rat pups. Unfortunately, a higher sensitivity to the action of antagonists of ionotropic glutamate receptors was demonstrated also for unwanted side effects (motor functions were compromized). In contrast, glutamate metabotropic receptor antagonist MPEP did not exhibit any serious side effects in rat pups.
INHERITANCE DISTRIBUTION OF KHUNTSA MUSYKIL (EFFEMINATE)
Authors: Abizar Muhammad Hafidz , Al Amin Habibi
Published: April 2023

This article is result of library research with a normative legal approach. Legal materials and data were obtained from Islamic legal norms regarding inheritance and khuntsa obtained from the texts of the Qur'an and Hadith, as well as the opinions of the jurists. This thesis discusses the distribution of khuntsa inheritance based on the opinion of Imam Ali As-Shobuni and Imam Abu Hanifah. People who do not have a clear gender status, not male and not female, are called khuntsa in Islamic law. One of the problems of khuntsa is in determining the right of inheritance. The Qur'an does not clearly state the portion of khuntha inheritance. This study concludes that in the unclear gender of khuntsa, it can be determined by two things, namely first, signs of maturity and second, where does urine come from. This argument is put forward using the istidlal theory used by Imam Ali As-Shobuni and Imam Abu Hanifah. If a khuntsa has a clear gender status, then this status follows the law of inheritance

Keyword : Khuntha mushkil, gender, inheritance.

 

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Droplets microfluidics platform—A tool for single cell research
Authors: Li Bixuan , Ma Xi , Cheng Jianghong , Tian Tian , Guo Jiao , Wang Yang , Pang Long
Published: April 2023

Cells are the most basic structural and functional units of living organisms. Studies of cell growth, differentiation, apoptosis, and cell-cell interactions can help scientists understand the mysteries of living systems. However, there is considerable heterogeneity among cells. Great differences between individuals can be found even within the same cell cluster. Cell heterogeneity can only be clearly expressed and distinguished at the level of single cells. The development of droplet microfluidics technology opens up a new chapter for single-cell analysis. Microfluidic chips can produce many nanoscale monodisperse droplets, which can be used as small isolated micro-laboratories for various high-throughput, precise single-cell analyses. Moreover, gel droplets with good biocompatibility can be used in single-cell cultures and coupled with biomolecules for various downstream analyses of cellular metabolites. The droplets are also maneuverable; through physical and chemical forces, droplets can be divided, fused, and sorted to realize single-cell screening and other related studies. This review describes the channel design, droplet generation, and control technology of droplet microfluidics and gives a detailed overview of the application of droplet microfluidics in single-cell culture, single-cell screening, single-cell detection, and other aspects. Moreover, we provide a recent review of the application of droplet microfluidics in tumor single-cell immunoassays, describe in detail the advantages of microfluidics in tumor research, and predict the development of droplet microfluidics at the single-cell level.
Validation of CRISPR activation system in Aedes cells using multicistronic plasmid vectors
Authors: Jaiswal Vijeta , Varghese Sara Ashok , Ghosh Sanjay
Published: April 2023

Aedes mosquitoes transmit several pathogens including flaviviruses to humans which result in high morbidity and mortality. Owing to adaptability and climate change, these mosquito vectors are predicted to establish in new geographical areas thus exposing larger populations to the risk of infection. Therefore, control of Aedes vector is necessary to prevent disease transmission. Recently, genetic approaches to vector control have shown promise; however, the tools and methods for manipulating the mosquito genome are rather limited. While CRISPR-Cas9 system has been adapted for gene editing purposes in Aedes mosquito, the dCas9-based transcription control of genes remain unexplored. In this study we report implementation of the CRISPR activation system in Aedes cells. For this we designed, constructed and tested a bi-partite plasmid-based strategy that allows expression of the dCas9-VPR and targeting guide RNA together with a reporter cassette. Quantitative analysis of the fluorescent reporter gene levels showed a robust over-expression validating CRISPR activation in Aedes cells. This strategy and the biological parts will be useful resource for synthetic transcription factor-based robust upregulation of Aedes genes for application of synthetic biology approaches for vector control.
Hemocompatibility of cellulose phosphate aerogel membranes with potential use in bone tissue engineering
Authors: Schimper Christian B. , Pachschwöll Paul , Maitz Manfred F. , Werner Carsten , Rosenau Thomas , Liebner Falk
Published: April 2023

Cellulose is an appealing material for tissue engineering. In an attempt to overcome some obstacles with cellulose II cell scaffolding materials related to insufficient biomineralization, lack of micron-size porosity, and deficiency in surface charge, respective solutions have been proposed. These included covalent phosphorylation of different cellulose materials targeting relatively low degrees of substitution (DS 0.18–0.23) and processing these cellulose derivatives into scaffolding materials by a dissolution/coagulation approach employing the hitherto rarely used TBAF/DMSO/H2O system for cellulose dissolution. Here, we report bioactivity and preliminary hemocompatibility testing of dual-porous cellulose phosphate aerogels (contrasted with the phosphate-free reference) obtained via coagulation (water/ethanol), solvent exchange and scCO2drying. Deposition of hydroxyapatite from simulated body fluid (7 days of immersion) revealed good bioactivity (1.5–2.2 mg Ca2+per mg scaffold). Incubation of the scCO2-dried and rehydrated scaffolding materials in heparin anticoagulated human whole blood was conducted to study selected parameters of hemostasis (prothrombin F1+2 fragment, PF4, count of thrombocyte-leukocyte conjugates) and inflammatory response (C5a fragment, leukocyte activation marker CD11b). Adhesion of leukocytes on the surface of the incubated substrates was assessed by scanning electron and fluorescence microscopy (DAPI staining). The results suggest that phosphorylation at low DS does not increase platelet activation. However, a significant increase in platelet activation and thrombin formation was observed after a certain fraction of the negative surface charges had been compensated by Ca2+ions. The combination of both phosphorylation and calcification turned out to be a potent means for controlling the inflammatory response, which was close to baseline level for some of the studied samples.
NIR-II fluorescence microscopic bioimaging for intrahepatic angiography and the early detection of Echinococcus multilocularis microlesions
Authors: Alifu Nuernisha , Yan Ting , Li Jun , Zhu Lijun , Aini Abudusalamu , Amuti Siyiti , Wu Juan , Qi Wenjing , Guo Gang , Zhang Wenbao , Zhang Xueliang
Published: April 2023

Hepatic alveolar echinococcosis (HAE) is caused by the metacestode of Echinococcus multilocularis, which shows characteristics of malignant tumors with high mortality. However, traditional diagnostic imaging methods are still not sufficient for the recognition of HAE microlesions in the early stages. Near-infrared-II (900–1700 nm, NIR-II) fluorescence microscopic imaging (NIR-II-FMI) has shown great potential for biomedical detection. A novel type of negative target imaging method based on NIR-II-FMI with the assistance of indocyanine green (ICG) was explored. Then, NIR-II-FMI was applied to the early detection of HAE for the first time. The negative targeting NIR-II fluorescence imaging of HAE-infected mice at different stages with the assistance of ICG under 808 nm of laser irradiation was obtained. Especially, HAE microlesions at the early stage were detected clearly. Moreover, clear intrahepatic angiography was achieved under the same NIR-II-FMI system.
Population analysis and the effects of Gaussian basis set quality and quantum mechanical approach: main group through heavy element species
Authors: North Sasha C. , Jorgensen Kameron R. , Pricetolstoy Jason , Wilson Angela K.
Published: April 2023

Atomic charge and its distribution across molecules provide important insight into chemical behavior. Though there are many studies on various routes for the determination of atomic charge, there are few studies that examine the broader impact of basis set and quantum method used over many types of population analysis methods across the periodic table. Largely, such a study of population analysis has focused on main-group species. In this work, atomic charges were calculated using several population analysis methods including orbital-based methods (Mulliken, Löwdin, and Natural Population Analysis), volume-based methods (Atoms-in-Molecules (AIM) and Hirshfeld), and potential derived charges (CHELP, CHELPG, and Merz-Kollman). The impact of basis set and quantum mechanical method choices upon population analysis has been considered. The basis sets utilized include Pople (6-21G**, 6-31G**, 6-311G**) and Dunning (cc-pVnZ, aug-cc-pVnZ;n= D, T, Q, 5) basis sets for main group molecules. For the transition metal and heavy element species examined, relativistic forms of the correlation consistent basis sets were used. This is the first time the cc-pVnZ-DK3 and cc-pwCVnZ-DK3 basis sets have been examined with respect to their behavior across all levels of basis sets for atomic charges for an actinide. The quantum methods chosen include two density functional (PBE0 and B3LYP), Hartree-Fock, and second-order Møller-Plesset perturbation theory (MP2) approaches.
Atypical flavobacteria recovered from diseased fish in the Western United States
Authors: Heckman Taylor I. , Yazdi Zeinab , Pomaranski Eric K. , Sebastião Fernanda de Alexandre , Mukkatira Kaveramma , Vuglar Brent M. , Cain Kenneth D. , Loch Thomas P. , Soto Esteban
Published: April 2023

Flavobacterial diseases, caused by bacteria in the order Flavobacteriales, are responsible for devastating losses in farmed and wild fish populations worldwide. The generaFlavobacterium(FamilyFlavobacteriaceae) andChryseobacterium(Weeksellaceae) encompass the most well-known agents of fish disease in the order, but the full extent of piscine-pathogenic species within these diverse groups is unresolved, and likely underappreciated. To identify emerging agents of flavobacterial disease in US aquaculture, 183 presumptiveFlavobacteriumandChryseobacteriumisolates were collected from clinically affected fish representing 19 host types, from across six western states. Isolates were characterized by 16S rRNA gene sequencing and phylogenetic analysis using thegyrBgene. Antimicrobial susceptibility profiles were compared between representatives from each major phylogenetic clade. Of the isolates, 52 were identified asChryseobacteriumspecies and 131 asFlavobacterium. The majority ofChryseobacteriumisolates fell into six clades (A-F) consisting of ≥ 5 fish isolates with ≥ 70% bootstrap support, andFlavobacteriuminto nine (A-I). Phylogenetic clades showed distinct patterns in antimicrobial susceptibility. TwoChryseobacteriumclades (F & G), and fourFlavobacteriumclades (B, G-I) had comparably high minimal inhibitory concentrations (MICs) for 11/18 antimicrobials tested. Multiple clades in both genera exhibited MICs surpassing the establishedF. psychrophilumbreakpoints for oxytetracycline and florfenicol, indicating potential resistance to two of the three antimicrobials approved for use in finfish aquaculture. Further work to investigate the virulence and antigenic diversity of these genetic groups will improve our understanding of flavobacterial disease, with applications for treatment and vaccination strategies.