bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of pulmonary vein isolation on the prognosis of patients with atrial fibrillation and heart failure with reduced ejection fraction: an updated systematic review and meta-analysis
Authors: Golukhova E. Z. , Bulaeva N. I. , Alexandrova S. A. , Berdibekov B. Sh.
Published: June 2024

Aim. The study aimed to conduct a systematic review and meta-analysis of randomized clinical trials (RCTs) to determine the effect of pulmonary vein isolation (PVI) on the prognosis of patients with atrial fibrillation (AF) and chronic heart failure with reduced ejection fraction (HFrEF).

Material and methods. We searched PubMed (MEDLINE), Google Scholar, and the Cochrane Library databases for studies that compared PVI with a conservative rhythm/heart rate (HR) control strategy in patients with AF and HFrEF. The primary endpoint in the major RCTs examining the effect of PVI on the prognosis of patients with HFrEF was a composite endpoint of all-cause mortality or HF-related hospitalization. Hazard ratios (HRs) based on Cox regression analysis were used as the baseline survival rates for the meta-analysis. To determine the weighted mean differences in improvement in left ventricular ejection fraction (LVEF) in the PVI and non-PVI groups, a pooled analysis of the mean LVEF changes with standard deviations taking into account the number of subjects in the compared groups was performed.

Results. For this systematic review, 11 studies were selected from 2216 publications, which included 2379 patients. Three RCTs (n=968) were subjected to meta-analysis on time-to-event outcomes. The average follow-up period was 34 months. According to the meta-analysis, PVI was associated with a significant reduction in the risk of composite endpoint (HR: 0,53; 95% confidence interval (CI): 0,33-0,85; p=0,009). In addition, PVI compared with drug rhythm/rate control was associated with a significant reduction in the all-cause mortality risk (HR: 0,55; 95% CI: 0,34-0,89; p=0,01). Finally, a meta-analysis of 10 RCTs (n=1516) found a significant improvement in LVEF compared with drug rhythm/HR control or atrioventricular node ablation with biventricular pacing. The weighted mean difference in the LVEF change over time after 6-12-month follow-up was 5,25% (95% CI: 4,03-6,47; p<0,001).

Conclusion. PVI in patients with AF and HFrEF compared with drug rhythm/HR control is associated with a significant reduction in the risk of all-cause mortality and HF-related hospitalization and a greater improvement in LVEF compared with baseline.
Type 1 Kounis syndrome: recurrent myocardial infarctions in a patient with aspirin-exacerbated respiratory disease: a case report
Authors: Boldueva S. A. , Yarmosh I. V. , Guzeva V. M. , Negrey Ya. V. , Savelyeva M. A.
Published: June 2024

Introduction. We present a case of type 1 Kounis syndrome in a patient with recurrent myocardial infarction with non-obstructive coronary arteries (MINOCA) due to allergic coronary vasospasm. Awareness of doctors about this pathology will allow identifying the MINOCA causes and prescribing pathogenetic treatment.

Brief description. A 51-year-old woman with aspirin-exacerbated respiratory disease (asthma, rhinosinusitis with nasal polyposis, aspirin hypersensitivity, eosinophilia) without cardiovascular risk factors developed three recurrent myocardial infarctions against the background of vasospastic angina over a 6-month period. Despite the typical clinical performance, stable ST segment elevation, unchanged coronary arteries on coronary angiography, the vasospastic MI was not immediately established. The patient received long-term treatment for type 1 MI, including beta-blockers. Recurrent MI occurred against the background of an asthma attack. During the second and third hospitalization for MI, coronary angiography revealed a spasm of the right coronary artery, which completely resolved with the nitroglycerin administration. Intracoronary ultrasound made it possible to rule out atherosclerotic involvement of the infarct-related artery. Subsequently, microvascular angina developed, which was confirmed by positron emission tomography. Vasospastic angina in combination with microvascular angina, MIBOCA with asthma attacks, were regarded as type 1 Kounis syndrome. Over the next 2 years, the patient received pathogenetic treatment, and no recurrent cardiovascular events were observed.

Discussion. Lack of awareness about Kounis syndrome led to incomplete examination of the patient with MIBOCA and the prescription of pathogenetically unreasonable tehrapy, which could contribute to recurrent MI within 6 months.
O BRINCAR E AS INTERAÇÕES NO COTIDIANO DO BERÇÁRIO
Authors: Novakowski Lutiane
Published: June 2024

Este texto apresenta uma experiência desenvolvida em uma turma de Berçário II, a qual intencionou valorizar e potencializar a brincadeira e a interação entre as crianças, ao mesmo tempo em que privilegiou as experiências que emergiam no cotidiano. Para tanto, foram adotadas diferentes intervenções na sala de referência e sobre os materiais ofertados para o brincar e para a exploração. Concomitante a isso, foi planejado e proposto diferentes experiências educativas organizadas por sessões, durante o decorrer do ano. Como resultados dessa experiência, percebeu-se que as crianças realizaram novas descobertas, testagens, elaboraram hipóteses, ampliaram seu vocabulário e foram se desenvolvendo demonstrando segurança e confiança durante as variadas experiências de brincadeira e interação. A experiência realizada reafirma que a intencionalidade educativa deve ser pensada, planejada e proposta a partir das necessidades e interesses que emergem do grupo atendido, levando em consideração, sobremaneira, a indissociabilidade entre as ações de cuidar e educar.
Methodological Approaches to Assessing the Economic Security of the Medical Device Manufacturing Industry
Authors:   Ural Federal University, Shtanko A. Yu.
Published: June 2024

The article examines methodological approaches to assessing the economic security of the medical device manufacturing industry. The study aims to determine the system of indicators of economic security in the medical device industry. To analyse main indicators and criteria of economic safety in medical device manufacturing, methods of statistical analysis and content analysis of relevant publications were used. In order to ensure a high level of economic security of the state, it is necessary to monitor the stable functioning of the healthcare system and, in particular, the medical device manufacturing industry. Since the findings revealed the absence in Russian regulatory and methodological documents of indicators and criteria for analysing and forecasting economic security in the medical device industry, the author’s methodological tools were developed. As a result, the paper presented a methodology for assessing the economic security of the medical device manufacturing industry, proposed indicators and criteria for measuring economic security based on an integral indicator, and considered threshold values of this indicator.
Development of the Online Education Sector in the Context of Digital Transformation
Authors:   Ural Federal University, Bovykin A. O. , Shmarova I. V. ,   Ural Federal University
Published: June 2024

Socio-economic changes taking place in the Russian Federation require the improvement of the education system, where digitalisation is now seen as the main trend. Therefore, the article considers advanced concepts of distance learning and their advantages and disadvantages. Also, as part of the study, a focus group survey was conducted to determine the attitude of respondents to the integration of information technology into educational institutions. The majority of respondents were in favour of further improvements to make remote learning more user-friendly in the future. As a result, the study presented an online learning model with improved aspects and proposed a solution for developing distance education programmes at universities.
Impact of Global Challenges on Russia’s Foreign Economic Development
Authors:   Institute of Economics of the Ural Branch of RAS, Glukhikh P. L.
Published: June 2024

Global challenges are often examined in works on foreign economic issues. However, the nature of their mutual influence on foreign economic activity remains debatable. The study aims to identify approaches to the relationship between global challenges and foreign economic development. To assess this interconnection, the methods of keyword search and content analysis of publications in the Russian database elibrary.ru for the period 2013–2023 were utilised. Various interrelations of global challenges with foreign economic development were established. Assessment of global challenges in the context of time was substantiated. The paper offered an interpretation of the cyclical nature of global challenges (origin, growth, peak impact and decline). The role of global challenges is not limited to the negative impact on foreign economic development, as one global challenge may be a reaction to another stronger challenge. The author’s theoretical positions can contribute to the theory of challenges.
Justification of Economic Modernisation of Regions based on Green Economy
Authors:   Vologda Research Center of RAS, Lebedeva M. A.
Published: June 2024

Currently, in the context of external and internal challenges in Russia, the search for internal sources of territorial development is of particular importance. One of them may be a modernisation based on green economy. The study aims to develop and test a methodology for justifying economic modernisation of regions on the basis of green economy. The proposed methodology substantiates the expediency of this kind of modernisation and reflects the duality of connections in the functioning of the territory’s economy. Its testing showed the expediency of economic modernisation on the basis of green economy in examined territories. This is due to the excess of the environmental deficit over the economic effect in some municipalities (Sheksninsky, Cherepovets Kaduysky municipal districts), as well as due to the increasing negative environmental deficit (Cherepovets city). Advantages and disadvantages of the developed methodology, as well as further research directions in this area are presented.
BehaviourCoach: Exploring the Use of a Web-Based Serious Game in Health Promotion
Authors: Grant Fiona , Elaheebocus Roushdat
Published: June 2024

Using a multidisciplinary approach, the current study examined the roles of psychological factors and serious games in the promotion of physical activity and wellbeing. The aim was to investigate the use and evaluation of a Web-based application named BehaviourCoach through the following research questions: How do users experience and evaluate this web-application for health promotion? How do elements of serious games and participants’ health status relate to intention to use this web-application? Participants (N = 55) engaged with BehaviourCoach for a duration of 45 minutes. Physical activity, psychological wellbeing, user experience, evaluation and intention to use a digital tool for health as well as demographic information were self-reported. On average, participants were sufficiently active as a group to meet the guidelines of 150 minutes per week of activity. They also reported moderate psychological wellbeing. The evaluation of the web application was positive, with participants expressing enjoyment, reporting that they found the game to support social interaction, and that the web application interface’s navigation was user-friendly. These factors were found to be positively related to intention to use the digital tool for health promotion in the future. In addition, participants’ levels of overall health and subjective wellbeing were predictive of intention to use the web-application for quick results. The study's implications for e-health interventions are discussed, as well as future directions.
Gamification in Retail: Enhancing Grocery Customer Experience with Location-Based Strategies
Authors: Zandi Alireza , Sekhavat Yoones A.
Published: June 2024

This study explores how gamification impacts customer experience in the retail sector emphasizing the need for businesses to differentiate in competitive markets. Gamification involves using game design elements in non-game contexts and is growing as a method to boost customer engagement and satisfaction. The research presents a unique gamified shopping system using location-based (Beacon technologies) with a custom mobile app. This system engages customers through interactive games and challenges in specific store locations. The app includes features like a suggestion page puzzle scoreboard and a points-based reward system. Study findings show a significant positive correlation between gamification strategies and improved customer experience (CX). Using game elements in non-game contexts enhances consumer behaviors and aligns with Self-Determination Theory principles. The app also integrates eco-friendly features and social interaction elements for an innovative and environmentally friendly approach to enhancing the retail customer experience.
Identifying critical assumptions and risks in air quality management planning using Theory of Change approach
Authors: Mukwevho Phathutshedzo , Retief Francois , Burger Roelof , Moolna Adam
Published: June 2024

Governments across the world have been developing legislation and policy implementation instruments to address air pollution issues. Air Quality Management Plans (AQMPs) have emerged as a key instrument, with most developed countries having established effective AQMPs. These take a variety of forms depending on the overarching national framework for environmental regulations. The uptake of AQMPs in low and middle-income countries, however, has been less broad and, even in those that have adopted AQMPs, their effectiveness and efficiency have been limited, especially in urban areas.  South Africa has adopted AQMPs and is recognised as having one of the most mature and complex air quality management legal frameworks in the world. Yet South Africa is still facing serious air quality challenges, especially in those areas that have been declared as priority areas. This paper, therefore, aims to identify critical assumptions and risks as a basis to evaluate the effectiveness of AQMPs as a policy instrument through the application of Theory of Change (ToC) approach. This study has resulted in the development of the ToC map, identification of 15 critical assumptions and associated causal narrative framework. In addition, this paper identified key risks underpinning the AQMP development and implementation process in South Africa. The identified critical assumptions embedded within different components of the ToC framework are not the only assumptions relating to this policy instrument, however, they are the fundamentally important ones that may significantly impact the success or failure of the AQMP system in South Africa if not managed. This study suggests that in order to further understand the challenges relating to the effective development and implementation of AQMPs, it is important that further research be conducted to test the validity of these critical assumptions which will provide solutions towards avoiding or mitigating risks associated with them.
Decarbonization of Africa: Metamorphosing the Continent for Sustainable Trajectories
Authors: Ogaya Jerico , Okesanya Olalekan John , Olatunji Gbolahan , Delos Santos Florante , Pedrajas-Mendoza Sharon Ann , Magramo Melchor , Sy Francis Ann R. , Lucero-Prisno Don Eliseo III
Published: June 2024

Africa has witnessed significant economic growth and development in recent years, driven by digitalization, industrialization, urbanization, and technological advancements. Despite contributing only a small fraction of global carbon dioxide emissions, Africa is facing the adverse impacts of climate change at an accelerated rate, with warming occurring faster than the global average. The urgent need to identify sustainable approaches for decarbonizing Africa has become paramount. This article highlights the challenges and pragmatic approaches to achieving decarbonization in Africa. The challenges encompass economic, social, and technological aspects, including difficulties in incorporating highly renewable energy and the lack of consideration given to system integration and non-financial aspects. Insufficient investments in low-carbon technologies, the absence of national-level commitments, and limited policies and financing options hinder progress toward decarbonization. Various pragmatic approaches are proposed to address these challenges. Expanding renewable energy sources through financial incentives and partnerships is crucial. Enhancing energy efficiency across sectors, promoting sustainable transportation, and adopting green building practices can significantly contribute to reducing greenhouse gas emissions. Emphasizing sustainable agriculture, forest conservation, and improving access to clean cooking services are vital for mitigating climate change and enhancing public health. Furthermore, international cooperation and financing are crucial in mobilizing resources for clean energy projects and decarbonization initiatives. Strengthening partnerships and creating supportive regulatory frameworks can attract private sector investment and promote a sustainable, low-carbon future for Africa.
Book Review: Sustainability of Southern African Ecosystems under Global Change
Authors: Feig Gregor , Veitch Jenifer , Graham Von Maltitz , Midgley Guy
Published: June 2024

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Infrações Ambientais: O caso de Araraquara - SP
Authors: Galvão Helton Alves de , Saran Maria Natália , Masiero Érico , Costa Daniel Jadyr Leite
Published: June 2024

Neste estudo, é realizada uma análise das infrações ambientais ocorridas no perímetro urbano do município de Araraquara/SP, durante os anos de 2019 e 2020, e sua incidência nas áreas circundantes e nas regiões demarcadas como Zonas Ambientais pelo Plano Diretor de Desenvolvimento e Política Ambiental de Araraquara (PDPUA). Utilizamos dados provenientes da fiscalização ambiental municipal, imagens de satélite do Google Earth, mapas do PDPUA e o software QGIS para o georreferenciamento das ocorrências. Geramos mapas temáticos relacionados às queimadas, à deposição de resíduos sólidos e à supressão ilegal de vegetação. A análise espacial revela pontos de concentração, especialmente de queimadas urbanas e deposição irregular de resíduos, nas áreas limítrofes do centro urbano e também nos bairros adjacentes às Zonas Ambientais. Os mapas gerados evidenciam áreas mais propensas ao risco de determinados tipos de infrações ambientais. Os resultados apontam para os pontos críticos dentro do centro urbano do município, onde a implementação e intensificação de ações de conscientização e educação ambiental são mais urgentes, bem como para a mitigação dos danos e recuperação das áreas afetadas.
Советская мозаика в современном российском городе: как монументальное наследие может вновь стать ценностью?
Authors: Студеникин Николай Анатольевич
Published: June 2024

В советское время была широко распространена практика оформления городской среды произведениями монументального искусства, благодаря чему такие объекты, как мозаичные панно, значительно повлияли на визуальный образ многих городов постсоветского пространства. В то же время, несмотря на свою богатую историю и культурное значение, сейчас они не рассматриваются как ценное наследие, достойное бережного отношения к себе. Мозаики ветшают и разрушаются, их демонтируют во время ремонтных работ, штукатурят, закрашивают или закрывают фальшфасадом.
Автор рассматривает советскую уличную мозаику как уникальный символический капитал территорий, которая может стать частью их бренда и помочь в трансляции локальной идентичности. Приводится анализ нескольких показательных прецедентов, когда панно были интегрированы в экономику города или стали его ярким визуальным символом. В результате исследования автор показывает, как советское мозаичное наследие может быть актуализировано в современных российских реалиях, определяет условия и способы возвращения советскому панно статуса ценности, выявляет существование явного общественного запроса на сохранение подобных объектов, а также намечает направление дальнейшей научной дискуссии на данную тему.
Post Mortem Interval Calculation of Oryctolagus Cuniculus Through Forensic Entomofauna – A Tool for Resolving Medicolegal Issues in Crime Scenes
Authors: Attaullah Mohammad , Ullah Fahim , Khan Imran , Ilahi Ikram , Zahoor Muhammad , Amin Muhammad , Ullah Riaz , Ali Essam A. , Jan Arif , Bibi Sidra
Published: June 2024

Post mortem interval (PMI) is an essential tool in crime scene investigations and is pivotal for resolving medicolegal issues. Developmental rates of insects can be utilized for the calculation of PMI of known and unknown animal and human cadavers. In the present study, PMI for rabbit, Oryctolagus cuniculus (Linnaeus 1758) was calculated through insect developmental rates and insect successional patterns on decomposing carcass of O. cuniculus. A total of 8 species of insects belonging to three orders and 8 families were identified on the O. cuniculus carcass. The blow fly, Chrysomya albiceps (Wiedemann 1819) belonging to the family Calliphoridae was the common and first visitor species to the rabbit carcass. The developmental rate of C. albiceps associated with the ambient climatic conditions was used as a model for the calculation of PMI. Temperature correction factor of the carcass temperature versus met station temperature was found as y = 0.9185x + 3.3624; R² = 0.8343. The accumulated degree days (∑ADD) were found as 535 while the accumulated degree hours (ADH) were found as 12842 with a resultant PMI of 7 days (ADD) and 167.4 h (ADH). Five decomposition stages of O. cuniculus were identified as fresh, bloated, active decay, advanced decay and dry remains stage. Findings of the present study can be applied for the calculation of PMI of known and unknown animal and human cadavers for resolving medicolegal issues in crime scenes.
An Ultrasensitive Electrochemical Enzymatic Urea Biosensor Based on Aniline/N-Butyl Acrylate Conducting Polymer-Modified Screen-Printed Electrode
Authors: Ulianas Alizar , Abu Hanifah Sharina , Tan Ling Ling , Rozi Normazida , Lee Yook Heng , Dewata Indang , Mawardi Mawardi , Yulkifli Yulkifli , Zainul Rahadian , Yuniarti Elsa , Suryani Okta , Kumala Sari Trisna
Published: June 2024

An enzymatic electrochemical biosensor for urea detection was developed using the succinimide-modified aniline/n-butyl acrylate (nBA) conducting polymer. This aniline/nBA conducting polymer was synthesized by photopolymerization with the succinimide moiety incorporated during the photocuring procedure. The urease enzyme originating from Jack beans was chemically grafted on the succinimide-functionalized aniline/nBA conducting polymer, which was attached to a screen-printed carbon paste electrode (SPE). The enzymatic hydrolysis of urea by the urease electrode diminished the voltammetric biosensor response as a result of the cascaded chemical reaction between the enzymatically hydrolyzed hydroxide (OH-) ion and the K3Fe(CN)6 redox species that generating the side products (Fe(OH)3, CN- ion, and KCN), which impeded the electron transfer of the redox mediator at electrode-electrolyte interface. In view of the amount of side products produced was proportional to the urea concentration associated in the enzymatic reaction with the immobilized urease enzymes, this has allowed the proposed enzymatic biosensor to demonstrate an inverse sensitivity concept of detecting urea concentration in an ultrasensitive manner. The electron transfer rate constant (k) of the urease electrode based on aniline/nBA hybrid material at the electrode-electrolyte interface was determined at 5.374×10-5 cm s-1. The linear response range of the enzymatic urea biosensor was obtained from 1×10-10 mM to 1×10-1 mM (R2=0.9834) by differential pulse voltammetry (DPV) with a limit of detection of 4.72×10-11 mM at pH 5.0 and enzymatic hydrolysis time of 30 min. The voltammetric urea biosensor response showed good reproducibility with a promising relative standard deviation (RSD) acquired at 5.0% (n=9). The ultra-high sensitivity performance of the developed enzymatic biosensor based on aniline/nBA conducting polymer towards determination of urea concentrations at low levels has demonstrated superior performance across previously reported electrochemical urea biosensors based on various nanostructured conducting materials.
Determining the Time Points for the Development of Early and Advanced Stages of Diabetic Cardiomyopathy in Streptozotocin-Induced Type 1 Diabetes Mellitus Rat Model
Authors: Jubaidi Fatin Farhana , Mohammed Yusof Nur Liyana , Zainalabidin Satirah , Taib Izatus Shima , Abd Hamid Zariyantey , Budin Siti Balkis
Published: June 2024

The characteristics of early and advanced stages of diabetic cardiomyopathy (DCM) are well-understood; however, the time points by which these stages are developed in animal models vary and depend on the hyperglycaemic status and duration of diabetes. This study was aimed to determine the time points for the development of early and advanced stages of DCM from the induction of type 1 diabetes mellitus by identifying the functional and histological changes that occurred. Type 1 diabetes was induced via streptozotocin injection, and rats were divided into 4-week and 8-week diabetic groups. A group of non-diabetic rats served as the normal control. Cardiac functions and structural changes were analysed. Results showed that after four weeks, all diabetic rats displayed early DCM characteristics, including pronounced left ventricular diastolic dysfunction and cardiomyocyte hypertrophy (P < 0.05) compared to the normal control. After eight weeks, there was a significant deterioration in both left ventricular systolic and diastolic function compared to the normal control, along with marked cardiomyocyte hypertrophy and myocardial fibrosis (P < 0.05), signifying the development of advanced DCM. In summary, this findings revealed the development of early and advanced stages of DCM at four weeks and eight weeks of diabetes respectively in diabetes melitus type 1 rat model.
Design and Characterisation of Curcumin-Loaded Nanostructured Lipid Carriers for Safe and Efficient Topical Drug Delivery in The Treatment of Pressure Ulcer
Authors: Mohd Shamsuddin Nur Amira , Azmi Fazren , Husain Khairana , Leong Lek Mun , Zulfakar Mohd Hanif
Published: June 2024

Pressure ulcers (PU) are chronic lesions with a high prevalence in at-risk populations. Although curcumin has various therapeutic properties, its use as a dermal therapeutic agent is limited by its poor solubility and permeability. This study aimed to develop nanostructured lipid carriers (NLCs) to facilitate the topical use of curcumin as wound healing agent in treating PU. The optimised curcumin-NLCs were characterised for their physicochemical properties, drug release, and skin permeation, while effectiveness and toxicity were investigated via cell viability, scratch assays, and an in vivo skin irritation test. The optimised curcumin-NLCs comprised 3.5% solid lipids, 1% surfactant, and 2% co-surfactant with an average particle size of 134.68±6.0 nm, polydispersity index of 0.248±0.00, zeta potential of −44.94±5.44, percentage of encapsulation efficiency of 93.42±0.32%, and drug loading of 0.11±0.00%. Curcumin-NLCs showed stable physicochemical properties and extended drug release for up to 48 h, with a cumulative release of 77.72% following a first-order kinetics. The formulation exhibited slower curcumin permeation than the free curcumin. Furthermore, the safe and non-toxic curcumin-NLCs were highly effective at 0.98 μM and showed a high rate of wound closure without skin irritation. Collectively, the NLCs developed for topical delivery of curcumin demonstrated prolonged and sustained release and improved wound healing activity, which indicates that curcumin-NLCs are a viable strategy for treating PU.
A Robust Design for the Omnibus SPRT Control Chart Under Skewed Data Distributions
Authors: Teoh Jing Wei , Teoh Wei Lin , Chong Zhi Lin , Lee Ming Ha , Khaw Khai Wah
Published: June 2024

Control charts are widely used in manufacturing industries to ensure that production levels are stable and satisfactory. Recently, the omnibus sequential probability ratio test (OSPRT) control chart was developed for the purpose of monitoring the mean and variability of a process simultaneously. As the OSPRT chart was proposed for the first time in literature, its development relied entirely on the assumption that data follow the Normal distribution. Nonetheless, researchers are frequently reminded that the quality characteristics of manufacturing processes do not necessarily follow the Normal distribution, e.g., strengths of glass fibres, and lifetimes of products. In this paper, we investigate the extent to which the performances of the OSPRT chart designed for the Normal model deteriorate, in situations where the data distributions are Gamma and Lognormal. Results show that the in-control average run length (ARL) and standard deviation of the run length of the OSPRT chart designed for the Normal distribution deteriorate rapidly as skewness increases. To address this issue, we propose a robust design for the OSPRT chart by adjusting its control limits, known as the skewness correction method. It is shown that the skewness-corrected OSPRT chart enjoys a guaranteed in-control ARL, with a justifiable degradation in its out-of-control performances. Besides, we also show some insights into selecting the charting parameters for the skewness-corrected OSPRT chart in order to achieve an optimum out-of-control ARL performance over various shift sizes. The paper wraps up with an illustrative example of the skewness-corrected OSPRT chart for monitoring the weights of radial tyres.
The efficiency of impact-disintegration-activation and enzymatic processing in protein hydrolysate technology from full-fat soy flour
Authors:   ITMO University, Zhdanova Anna P. , Barakova Nadezhda V. ,   Saint-Petersburg State Institute of Technology, Baskovtceva Angelina S. ,   ITMO University, Chelombitkin Mikhail A. ,   ITMO University, Samodelkin Evgeniy A. ,   Research Center "Kurchatov Institute" – Central Research Institute of KM "Prometey"
Published: June 2024

The impact of impact-disintegration-activation processing (IDAP) of soybeans on oxidative processes in full-fat soy flour has been studied. It was found that during the storage of flour obtained after IDAP, the acidity value increases slowly compared to the flour obtained after processing soybeans with a rotor-blade mill processing (RBMP). After 1 month of storage, the difference in acidity value between the two processing methods favored IDAP by 1.7%, after 4 months of storage – by 34%, and after 12 months of storage – by 31.3%. After 12 months of storage, the acidity value in full-fat soy flour obtained after IDAP increased by 54%, while in the flour obtained after RBMP, it doubled. The reduction in the rate of lipid oxidation is justified by the higher content of phenolic compounds – antioxidants in the flour obtained after IDAP. The flour obtained after IDAP contains 27.4% more phenolic compounds than the flour obtained after RBMP. The impact of IDAP on the effectiveness of enzymes with different substrate specificity has been investigated. IDAP of soybeans ensures more active participation of amylolytic, cellulolytic, and proteolytic enzymes in enzymatic hydrolysis. The protein and amino acid content in hydrolysates after IDAP was higher compared to samples after RBMP. It has also been shown that in the case of IDAP of soybeans, xylanase, and a complex of xylanase and protease are necessary to obtain a higher content of soluble protein and amino acids in the hydrolysate. In the case of RBMP of soybeans, a complex of alpha-amylase and protease should be added. All the results obtained during the study demonstrate the effectiveness of IDAP of soybeans in the technology of protein hydrolysates. These findings are also applicable to the production of protein hydrolysates from other legumes and cereals.
"Alcoholic" fermentation of tobacco in oak barrels. Part 1. Tannin mass transfer and its indirect quantitative determination by HPLC
Authors:   Pogar Сigarette & Сigar Factory, Moiseev Igor V. , Karmanov Denis A. ,   Pogar Сigarette & Сigar Factory, Leznyy Valerii V. ,   Pogar Сigarette & Сigar Factory, Bondarenko Dmitriy V. ,   Pogar Сigarette & Сigar Factory, Sinchin Gregoriy P. ,   Derbent Brandy Factory
Published: June 2024

The quantitative transition of oak tannin into raw tobacco during its fermentation in oak barrels in the gas-liquid medium of cognac distillate was studied. The object of research was Cuban cigar tobacco of the HP variety. The fermentation process was carried out for six months with periodic (1–2 weeks) treatment of the inner surface of the barrel with cognac distillate with an alcohol content of 70 vol.% in an amount of 1,5 cm3/dm2. To obtain data on tannin mass transfer, we developed a method for the quantitative indirect determination of tannin in oak and tobacco raw materials using reverse-phase high-performance liquid chromatography (RP HPLC) through preliminary hydrolysis of tannin to gallic acid. The determination of gallic acid/tannin was carried out on a liquid chromatograph with a spectrophotometric detector (UV) at a wavelength of 280 nm using the external standard method. The analysis of unfermented tobacco raw materials did not reveal the presence of tannin. It has been shown that under the specified conditions, during 6 months of fermentation, diffusion of tannin from oak staves into tobacco is observed in an amount of 0,11% by weight of tobacco. The mass fraction of tannin in oak staves was 0,81%. At the same time, the most intense saturation occurs in the 1st, 4th, and 5th months of fermentation.
The Effect of Packaging Type and Storage Time on the Quality Characteristics of Chicken Nugget with Jack Bean (Canavalia ensiformis L.) Tempeh Flour Substitution
Authors: Giovani Sarah , Oktafiani Zahra Ismi , Komalasari Ema , Setiyoko Agus
Published: June 2024

Chicken nuggets with jack bean tempeh flour substitution are a type of perishable food, thus having a short shelf life. The shelf life of chicken nuggets with jack bean tempeh flour substitution and its quality were affected by the storage conditions. This study aimed to determine the effect of packaging type and storage time during 20 days of cold storage on the quality characteristics of chicken nuggets with jack bean tempeh flour substitution. The research design consisted of two factors, the first factor was packaging type (nylon/polyethylene (PE), nylon-polyethylene (PE)/polyamide (PA), and polyethylene (PE)/polyamide (PA)) and the second factor was storage time (0 day, 5 days, 10 days, 15 days, and 20 days). The results showed that the packaging type and storage time significantly affected the quality characteristics of chicken nuggets with jack bean tempeh flour substitution. In conclusion, PE/PA was more effective in maintaining the quality characteristic of chicken nuggets with jack bean tempeh flour substitution on the 20th day of storage based on pH of 6.43, cooking loss of 9.85%, moisture content of 39.46%, protein content of 24.51%, and TPC of 5.36 log cfu/g. Meanwhile, the result of the sensory evaluation showed that scores for attributes were color 3.63, taste 3.5, texture 3.29, and overall 3.53 (like slightly) on the 20th day of storage.
Vocatives and Their Functions in the Story by A.S. Pushkin “The Captain’s Daughter” (to the 225th Anniversary of the Birth)
Authors: Chernikova N.V.
Published: June 2024

The article discusses different types of vocatives that are performed in the story by A.S. Pushkin's "The Captain's Daughter" has a number of significant functions. It has been established that they not only serve as a means of nomination and identification of the addressee, but also perform equally important functions — social-regulatory and emotive. It has been revealed that neutral, characterological and ironic addresses create a speech portrait of the speaker, evaluate the characters of the work, indicate their social status, characterize actions, reveal the inner world, demonstrate the relationship between communicants.
Scalability of Urban Agriculture
Authors: Jones Kristin
Published: June 2024

Urban farming and community gardening are gaining popularity as strategies to address food insecurity and inequities in city life. Urban agriculture has been proposed as a way to enhance a city’s resilience. This concept is not new, as Ludwig Hilberseimer and Alfred Caldwell demonstrated in the 1940s when they envisioned a more resilient city for the industrialized world utilizing a decentralized, linear development model within a productive living landscape. In asserting that “small farms could solve mass poverty, mass unemployment and inflation– our great national disasters,” Caldwell presented a vision of small-scale farming as an act of resistance and empowerment for individuals, with the goal of initiating large-scale social and environmental transformation. This study takes Caldwell’s assertion as a starting point to investigate what we can learn from existing examples of urban agriculture in order to enhance urban resilience.
The research examines three distinct approaches to urban farming currently implemented in Chicago, aiming to extrapolate their scalability and impact on broader societal and environmental change. The selected cases represent a range of farming practices and organizational types, encompassing conventional raised bed farming, aquaponics, hydroponics, and permaculture. Organizational diversity is reflected in the inclusion of a large non-profit organization, a local community group, and a private entrepreneur. Each case is analyzed based on a) The specific approach to farming technologies and practices, b) The corresponding development and implementation process leading to fruition, c) Evaluation of its transformative effects on individuals and its broader societal and environmental impact, d) Identification of perceived opportunities or barriers to growth and long-term success. The study identifies numerous opportunities for scaling up and emphasizes the varied objectives in urban agriculture. To support the growth of urban agriculture within resilient cities, a comprehensive multi-faceted, multi-scalar framework is necessary.
Propiedades Psicométricas de la escala de Florecimiento en adultos de la provincia de Trujillo
Authors: Esquivel-Ledesma Tatiana Esther , Hoyos-Díaz Alex David , Salirrosas-Cabada Richard Irvin
Published: June 2024

Se planteó como objetivo general determinar las evidencias de validez de la escala de Florecimiento y como objetivos específicos, hallar las evidencias de estructura interna, validez de criterio y de contenido; así como, la confiabilidad por consistencia interna. El tipo de investigación fue aplicada con un diseño instrumental, la muestra estuvo conformada por un total de 520 personas de ambos sexos. Los resultados muestran valores aceptables en los índices de ajuste (X22.28, SRMR.038, RMSEA.059, CFI.958, PCFI.684), se confirmó la convergencia y divergencia con las variables Satisfacción con la Vida, Bienestar Psicológico, Depresión, Ansiedad y Estrés; y la confiabilidad por omega de McDonald (.796). Se concluye así, con un instrumento válido y confiable unidimensional de ocho ítems, que puede ser utilizado en adultos de la provincia de Trujillo.
Experiencia en el tratamiento de las fístulas perianales complejas en un hospital público. 2018-2022
Authors: Santacruz-Bareiro Eduardo Roberto
Published: June 2024

Introducción: El tratamiento de la fistula perianal compleja es controvertido, requiere de un conocimiento anatómico preciso y de métodos auxiliares de diagnóstico para ofrecer el mejor resultado posible al paciente. Objetivos: Describir la experiencia en el tratamiento de las Fístulas Perianales complejas en un Hospital Público en el periodo 2018 - 2022. Material y Métodos: Estudio observacional descriptivo de corte transversal, no probabilístico de casos consecutivos de pacientes con diagnóstico de fistula perianal compleja ingresados en el servicio de coloproctología del Hospital Nacional de Itauguá en el periodo de enero de 2018 hasta diciembre de 2022, de los cuales 21 cumplen con los criterios de inclusión de fistula perianal compleja. Resultados: De los 21 pacientes, 76% fueron hombres, con una media de edad de 35 años ± 10, el principal motivo de consulta fue secreción anal en 19 pacientes. En cuanto al tipo de fístula se identificó un 81% de fístula transesfinteriana alta, en cuanto al tratamiento, se realizó en un 48% fistulectomìas, en cuanto a las complicaciones, solo en un 10 % de los pacientes se constató recidiva de la fístula que fue tratada con fistulotomía con colocación sedal. Conclusión: La fístula perianal compleja es una patología periorificial poco frecuente, son fundamentales los datos obtenidos por el examen físico y la posibilidad de efectuar estudios complementarios con recursos tecnológicos avanzados para su resolución satisfactoria.
Unveiling supply chain efficiency: exploring ABC-VED analysis studies on drug inventory management in India
Authors: Meena Dinesh K. , Mathaiyan Jayanthi
Published: June 2024

About one-third of annual hospital budget is spent on buying materials and supplies including medicines. In any health facility, be it small health center or a big teaching institution, drugs forms an essential and indispensable element. Non-availability of drugs particularly in the developing countries is due to lack of proper material management. A poor management in a public pharmaceutical supply can result in wastage or blockade of financial resources, irrational utilization of drugs, shortage or overage of essential drugs, increased holding cost, and reduction in flexibility and decline in quality of health care services. Adaptation of a scientific approach of inventory management in healthcare manages all the issues regarding stocking of pharmaceutical items, ensuring safety, stability, efficacy, availability and maintenance of quality of drugs to provide better healthcare services. This review will focus on inventory management and its importance with special emphasis on always better control-vital, essential, desirable (ABC-VED) analysis technique on essential medicine concept and report of various research studies conducted on ABC-VED analysis in different parts of country.
Scope of dermatological practice among transgenders seeking cosmetic advice
Authors: Anilkumar Sukhada , Thomas Irene Nirmala , Priyadharshini Nithya
Published: June 2024

Transgender women are persons who are assigned male at birth, but who identify themselves as women. They aspire to display female characteristics both in appearance and attitude. Transgender women try to exhibit their female sexuality through the extensive usage of cosmetological interventions such as epilation of facial hair, control of acne, whitening treatments and excessive usage of makeup on face as the face serves as the part of body that helps to project their sexual characteristics. The prolonged and inappropriate usage of such interventions can lead to complications for which these group of individuals seek Dermatologic advice. Due to the rampant usage of steroid containing creams by our population in general and transgender community in particular as a means to overcome body dysmorphia, dermatologists have the responsibility to give proper advice regarding the complications following any cosmetological interventions. We report three transgender females who came to the OPD with skin thinning, acne, hypertrichosis and telangiectasia following the usage of topical steroid containing facial whitening creams.
Hypovitaminosis-D and sexual dysfunction
Authors: Samreen  , Khan M. Imran , Saxena Archna , Chakraborty Rajarshi
Published: June 2024

Sex has a significant impact on a person's quality of life. Numerous elements, including endocrine, vascular, psychological, and neurological ones, have an impact on sexual function. Male and female sexual dysfunction is a prevalent issue in both sexes. About 30% of males and 40% of women are reported to have sexual dysfunction. The main factors influencing sexual responsiveness are neurological and endocrine activity. An increased risk of obstetric and gynecologic issues, including endometriosis, polycystic ovaries, infertility, gestational diabetes, preeclampsia, and ovarian and breast cancer, is also linked to vitamin-D insufficiency. Data from several studies conducted worldwide indicate that vitamin D is vital for both male and female sexual function.
Expert opinion on current issues and challenges in irritable bowel syndrome
Authors: Lawate Parimal
Published: June 2024

Irritable bowel syndrome (IBS) is a widely prevalent functional gastrointestinal disorder characterized by symptoms such as abdominal pain, irregular bowel movements, and bloating, which significantly impact affected individuals' well-being. The increasing prevalence of IBS in India places a substantial burden on clinical practice. Although diagnostic criteria, such as the commonly used Rome IV criteria, have shown reasonable sensitivity, the diagnosis of IBS remains a nuanced and culturally influenced process. This comprehensive review systematically examines current challenges surrounding IBS prevalence, diagnostic intricacies, and the complex pathophysiology involving visceral hypersensitivity. The review highlights the imperative for noninvasive biomarkers to augment diagnostic precision and emphasizes on following a holistic approach to IBS management as advocated by Indian guidelines. This approach integrates dietary modifications, antispasmodic medications, psychological therapy, and yoga, with specific emphasis on tailoring treatments to individual IBS subtypes. Among antispasmodic drugs, pinaverium bromide because of its unique mechanism of action as a calcium channel antagonist within the gastrointestinal tract has shown promise in alleviating IBS symptoms.
Ethambutol induced subacute cutaneous lupus erythematosus in an elderly female with co-morbidities
Authors: Wadhwa Priyanka , Modi Vaishnavi , Suri Arushi , Barman Krishna D. , Mallya Varuna , Dev Tanvi
Published: June 2024

Papulosquamous lesions in an elderly female with multiple co-morbidities often pose diagnostic challenge. We present an interesting case of anti-tubercular treatment (ATT) induced sub-acute cutaneous lupus erythematosus. The patient presented with papulosquamous lesions in generalised distribution, which showed interface dermatitis on histopathology. The serology for anti-nuclear antibodies, anti-Ro and anti-La was positive. The rash resolved spontaneously after stopping all the suspected drugs. Oral provocation was performed with first line anti-tubercular drugs and ethambutol was found to be the culprit drug, which was later confirmed by reappearance of skin rash by inadvertent ingestion of one dose of ethambutol by the patient.
Refleksja i działania Kard. Josepha Ratzingera wobec niemożliwości udzielania święceń kobietom. Wybrane kwestie teologiczno-prawne
Authors: Trojanowski Bartosz
Published: June 2024

Problem niemożliwości święcenia kobiet został obszernie wyjaśniony przez Kongregację Nauki Wiary w 1976 r. poprzez deklarację Inter insignores, jednak po ukazaniu się tego dokumentu dyskusja nie została zakończona, co więcej pojawiały się głosy, że kwestia ta jest nadal otwarta. W związku z tym, okazała się konieczna interwencja papieskiego Urzędu Nauczycielskiego, aby tę kwestię przedstawić w sposób ostateczny. Jednakże i ta kwestia poddana była dalszym dyskusjom i różnego rodzaju konstatacjom. Dlatego też refleksja kardynała Josepha Ratzingera nad tym zagadnieniem stanowi nie tylko podkreślenie, iż Kościół nie może przekroczyć granic, które stanowią jego konstytutywne elementy, ponieważ nie ma takiej władzy. Natomiast teologiczne podstawy poszczególnych kategorii prawd przekładają się na ich normatywne oraz dyscyplinarne zapisy w prawie kanonicznym. Stąd też artykuł podejmuje kwestię zależności refleksji teologicznej kardynała Ratzingera i jej konsekwencje w prawodawstwie powszechnym Kościoła.