bluuebunny/crossref_metadata_2025 huggingface dataset:
A novel approach involving a microcatheter tip during aneurysmal coil embolization: The Γ (gamma) tip method
Authors: Ohshima Tomotaka , Miyachi Shigeru , Matsuo Naoki , Kawaguchi Reo , Maejima Ryuya , Takayasu Masakazu
Published: July 2019

Complete and secure occlusion of the entire aneurysmal neck remains a problem despite major advances in the treatment of intracranial aneurysms using endovascular coil embolization. Here, we present our initial clinical experience using a novel strategy for endovascular coil embolization involving a microcatheter tip, known as the “Γ (gamma) tip method,” and compare the in vitro results of this technique with those of conventional straight microcatheters. The microcatheters were bent at a right angle starting 1–2 mm from the length of the tip using a catheter-shaping mandrel and a hot air gun. The tiny right-angled tip is the “Γ tip.” In aneurysm models, we assessed the efficacy of shaping during coil deployment. The Γ-tipped microcatheters demonstrated better movement and oscillation during insertion of the coil into the aneurysm compared with the straight-tipped catheters. Moreover, the Γ-tipped microcatheter provided less coil protrusion into the parent artery and less microcatheter kickback compared with the straight tip. With the Γ-tipped microcatheter, even if the first coil loop migrated into the parent artery, its subsequent dynamic movement routed it back into the aneurysm. The Γ tip method enabled smooth movement of the microcatheter into the aneurysm, demonstrating the safety and security of coil insertion using the Γ tip compared with the conventional straight tip.
Contrast extravasation after angioplasty for symptomatic stenosis of the middle cerebral artery: A case report
Authors: Wang Xiaohui , Yang Bin , Zhu Haojing , Jiao Liqun
Published: July 2019

Contrast extravasation is a common phenomenon in acute ischaemic stroke patients who are treated with endovascular therapy, but it is rarely reported in selective angioplasty of intracranial artery stenosis. In this case we present the treatment and follow-up studies of a patient with severe stenosis in the M1 segment of the middle cerebral artery. We observed extravasation of contrast medium in the brain tissue around the stent after the operation by a computed tomography scan taken immediately, but the patient did not experience any neurological deficits during the operation and the 4-year follow-up. Also the contrast extravasation did not transform into haemorrhage or hyperperfusion.
Design and fabrication of a microelectromechanical system resonator based on two orthogonal silicon beams with integrated mirror for monitoring in-plane magnetic field
Authors: Acevedo-Mijangos Jesús , Ramírez-Treviño Antonio , May-Arrioja Daniel A , LiKamWa Patrick , Vázquez-Leal Héctor , Herrera-May Agustín L
Published: July 2019

We present a resonant magnetic field sensor based on microelectromechanical systems technology with optical detection. The sensor has single resonator composed of two orthogonal silicon beams (600 µm × 26 µm × 2 µm) with an integrated mirror (50 µm × 34 µm × 0.11 µm) and gold tracks (16 µm × 0.11 µm). The resonator is fabricated using silicon-on-insulator wafer in a simple bulk micromachining process. The sensor has easy performance that allows its oscillation in the first bending vibration mode through the Lorentz force for monitoring in-plane magnetic field. Analytical models are developed to predict first bending resonant frequency, quality factor, and displacements of the resonator. In addition, finite element method models are obtained to estimate the resonator performance. The results of the proposed analytical models agree well with those of the finite element method models. For alternating electrical current of 30 mA, the sensor has a theoretical linear response, a first bending resonant frequency of 43.8 kHz, a sensitivity of 46.1 µm T−1, and a power consumption close to 54 mW. The experimental resonant frequency of the sensor is 53 kHz. The proposed sensor could be used for monitoring in-plane magnetic field without a complex signal conditioning system.
Rarefied flow and heat transfer characteristics of rectangular cavities with heated concave surface
Authors: Alkhalidi Ammar , Kiwan Suhil , Al-Kouz Wael , Owhaib Wahib , Alshare Aiman
Published: July 2019

This article utilizes the finite volume method to solve the problem incorporating rarefied flow and heat transfer characteristics inside concaved cavities. Cavities are used in many applications, one of which is building insulation to reduce heat loss from walls. In this article, the influence of the aspect ratio ( B/ H), the tilt angle ( θ), Knudsen number ( Kn), and Rayleigh number ( Ra) on these characteristics were studied. Parameters ranges were [Formula: see text]. This study shows that the average Nusselt number ( Nu) decreases as the B/H and Kn increase. Whereas, Nu increases with increasing Ra. In addition, the Nu increases as θ increases to a given critical angle (60°), and beyond this angle, Nu decreases with increasing Ra. A new correlation of Nu including all parameters investigated in this work is introduced. This study reveals that concaved cavities could be used as thermal insulation bodies.
Reducing the risk of athlete burnout: Psychosocial, sociocultural, and individual considerations for coaches
Authors: Davis Louise , Stenling Andreas , Gustafsson Henrik , Appleby Ralph , Davis Paul
Published: July 2019

Past research suggests that athletes’ relationships with their coach can act as a risk factor in the development of burnout. Coaching practice may be enhanced through understanding the multidimensional factors that can augment the associations between coach–athlete relationship quality and athlete burnout. The present study explored both individual difference characteristics (gender, age, and sport level) and sociocultural factors (sport type) as moderators of this relationship. Our findings show statistically significant interaction effects for gender and age. Coaches and practitioners working with younger athletes and male performers in particular, are advised to work with strategies aiming to build relationships and reduce the risk of burnout.
Communicating legitimacy through portrayals of successful aging: An examination of Pulte homes’ online communication strategies
Authors: Anderson Lindsey B
Published: July 2019

The aging population has created implications for many industries, especially in terms of establishing legitimacy among stakeholders. One industry that has been affected by the shifting demographics is homebuilding. Older adults must consider future housing needs that allow for successful aging. However, the current inventory of houses and neighborhoods are not necessarily built to suit this population. Pulte Homes, a national homebuilding company, has a line of active adult communities under the name Del Webb. To understand how Pulte communicates legitimacy for this housing product, I completed a qualitative content analysis of the Del Webb section of the organizational website that integrates the tenets of the Communication Ecology Model of Successful Aging (CEMSA) with five discursive strategies for establishing legitimacy. In doing so, I found that Pulte constructed an idealized portrayal of age/aging by emphasizing the need to (1) plan for future needs, (2) express optimism about aging, (3) resist age-based stereotypes, and (4) minimize the role of communication technology. Based on these findings, Pulte’s discourse ultimately positions Del Webb as a utopia for older adults/space that facilitates ‘successful’ aging and raises questions about the transparency of this organizational discourse.
Contextual awareness on organizational crises: National context and crisis attribution
Authors: Zhao Hui
Published: July 2019

This study examines the influences of national contexts on crisis attribution to address the recent appeal for a more contextually sensitive perspective in crisis communication research. Specifically, this study revisits the situational crisis communication theory (SCCT) in the Chinese context by taking an online discussion on Weibo about a high-profile homicide in a McDonald’s restaurant as the case. Built on the framing theory and categorization of national contexts, an inductive framing analysis of 100 top forwarded posts demonstrates a complex negotiation process of context-embedded frames and its significant impacts on crisis attribution. The model of SCCT is then refined by integrating national contexts into the concept of ‘modifier’. Implications for both theory and practice are also discussed.
Localized Sinonasal Amyloidosis
Authors: Wahid Nur Wahidah , Abed Tarik , Meghji Sheneen , Gilbertson Janet , Barnes Martyn
Published: July 2019

Localized amyloidosis involving the nasal mucosa is rare, with only 38 published cases reported to date. We report a case of amyloidosis localized to the sinonasal tract. A 61-year-old man presented with a 1-year history of left-sided nasal obstruction. Endoscopic examination and computed tomography revealed the presence of a nasal mass originating from the left inferior turbinate. The patient subsequently underwent an examination under anesthesia and an excision biopsy of the nasal mass. Histology confirmed amyloidosis with no immunospecific stains. Systemic amyloidosis testing was negative, leading to a diagnosis of localized sinonasal amyloidosis of nonamyloid A (AA) subtype. To our knowledge, this is the second reported case of non-AA subtype of the sinonasal tract. The patient was managed conservatively and is currently under close follow-up.
The META-Oak Project: Using Photovoice to Investigate Youth Perspectives on Tobacco Companies’ Marketing of E-Cigarettes Toward Adolescents in Oakland
Authors: Chopel Alison , Lee R. Eugene , Ortiz-Matute Elizabeth , Peoples Namiyé , Homer Vagadori Kim , Curtis Andrew , Ling Pamela M.
Published: July 2019

The California Adolescent Health Collaborative, a project of the Public Health Institute, in partnership with the University of California, San Francisco’s Center for Tobacco Control Research and Education jointly led a community-based participatory research (CBPR) study engaging youth coresearchers to fill the critical gap in knowledge about youth’s perceptions of electronic cigarette products and how they are marketed toward young people in Oakland. Youth coresearchers who were trained as journalists partnered with the adult investigators to explore the e-cigarette topic from their perspective, embedded in the context of their own experiences and those of others in their communities. The goal of this exploratory CBPR study was to improve understanding of how and why youth (ages: 14-24 years) in Oakland are adopting (or resisting) e-cigarettes, how youth respond to increasing availability of e-cigarettes in their communities, and how they perceive communications about e-cigarettes (e.g., advertising) and in turn communicate about the products to each other.
Chance of Civic Education in Russia
Authors: Tolstenko Andrew , Baltovskij Leonid , Radikov Ivan
Published: July 2019

This article shows how education, which is the most important form of activity in the social medium, changes the cultural image and awareness of individuals, and shapes and transforms their political attitude toward the surrounding day-to-day realities. A comparison analysis is used to explore a civic education system that forms the national and state identity of a person as a derivative of an “imagined community.” This phenomenon will be regarded here as the result of designing social and political values and their internalization in the public consciousness. This approach makes it possible to optimize the process of education for the public sphere which is destined to form an active citizen, to create a sustainable link between an individual and the social medium and is the most important tool of political communication.
A Phenomenographic Research Study of Students’ Conceptions of Mobile Learning: An Example From Higher Education
Authors: Khan Md. Shahadat Hossain , Abdou Benadjih Oiriddine , Kettunen Jaana , Gregory Sue
Published: July 2019

This article aims to identify different ways of using mobile devices in students’ learning in higher education. This qualitative research presents the findings from a phenomenographic research of students’ conceptions of mobile learning (m-learning) in higher education. A cohort of 16 students from four universities of Bangladesh took part in semi-structured interviews to explore their in-depth understandings and experiences of m-learning. The findings indicate that university students perceived five qualitatively different ways of using mobile devices in their learning: a medium for communication; a medium for management of learning materials; a tool for effective learning; a means for collaborative learning; and a means for development of new ideas. The findings of this research demonstrate students’ pedagogical understanding of using mobile devices in higher education. The outcomes of this research could play a crucial role in informing students on how they can use their mobile devices for learning purposes and providing educators with empirical evidence on students’ pedagogical practices of using mobile devices in other developing and more developed countries in the world.
Canton Kung Fu: The Culture of Guangdong Martial Arts
Authors: Ye Guo
Published: July 2019

During the 20th century, a version of Kung Fu from the Guangdong region in Southern China became more widely known abroad as a result of Chinese migration to the West, as well as its exposure through popular culture, including the films of Bruce Lee. This article analyses the culture of Guangdong martial arts in the context of this growing exposure. A variety of martial arts sects and associated cultural expressions in other fields give a picture of the traditional martial arts culture in Guangdong. Underpinning these physical manifestations, Guangdong martial arts have derived their ideologies from traditional Chinese philosophy. The dynamic social system supporting Guangdong martial arts provided a platform ensuring that these cultural symbols and values could be created and maintained and exported over several centuries.
Mapping Teaching Through Interactions and Pupils’ Learning in Mathematics
Authors: Gamlem Siv M.
Published: July 2019

The aim of the study is to map patterns of teaching quality through interactions in Mathematics lessons in lower secondary school classrooms. The sample is 10 ninth-grade classrooms in Norway (pupils’ age, 14-15 years). Reciprocal linkages between teaching through interactions in Mathematic lessons and pupils’ results on a standardized National Curriculum Mathematic Test, before and after observed lessons ( N = 115) over 7 months, are studied. To map quality of teacher–pupil interactions in classrooms, observations are video recorded and analyzed using Classroom Assessment Scoring System. Video analyses elicit that there is a variety in teacher–pupil interaction quality in the 10 classrooms concerning “emotional support,” “classroom organization,” and “instructional support.” The lowest quality is found for the dimensions “analysis and inquiry,” “instructional dialogue,” and “regard for adolescent perspectives,” which might preclude facilitation of cognitive and metacognitive strategies to enhance pupils’ learning and engagement in work with instructional content. Highest quality in teaching through interactions is found for the dimensions “behaviour management” and “productivity.” Analyses show that “positive climate” and “student engagement” both have strong effect sizes and are significant concerning pupils’ learning on class level when comparing classrooms with the highest and lowest improvement score on the standardized National Curriculum Math test over 7 months.
Here’s Why I Joined: Introductory Letters From New Hires to The Athletic and the Framing of Paywall Journalism
Authors: Clavio Galen , Moritz Brian
Published: July 2019

The transition of newspapers from traditional revenue models to digital advertising-based models has been fraught with financial peril, with many formerly strong news organizations laying off journalists or closing entirely. The launch of The Athletic, a subscription-only digital site for sport coverage and opinion, has been watched with great interest within the sports journalism world, as it represents a new method of financing journalistic endeavors. The majority of hires at The Athletic over its first few years have been marketable writers from traditional newspaper backgrounds. This study utilizes a qualitative methodology to examine introductory stories written by new hires to The Athletic (N = 88). Through open coding, the study evaluated these stories for common themes relating to the authors’ newfound employment and transition to a supposedly new model of journalism. The study found three overarching themes, centered on the writers’ explanations of their own biographical backgrounds, attempts to convince the audience of the superiority of the new editorial model being employed by The Athletic, and communicating to the audience what they should expect and deserve. Framing theory is utilized as a guiding theoretical perspective as themes from the stories, and their underlying implications are discussed.
Experiments in Economics: A Survey
Authors: Gupta Gautam
Published: July 2019

Application of experimental methods in Economics, over the last few decades, has given researchers in the field access to hitherto unobtainable data that can be used to validate or refute theoretical propositions. This field has grown exponentially during this time but is still rather new to the average academic. This article is in the nature of a survey of more recent literature. It begins with the early beginnings in the area and goes on to discuss recent advances, thematically, with special emphasis on artefactual and framed field experiments as well as natural experiments. The discussion is by no means exhaustive and is intended to bring to the interested reader a flavor of experimental methods.
An Intensive Care Unit Outbreak of Acute Respiratory Distress Syndrome due to Human Metapneumo Virus Infection
Authors: Sinha Ankur , Ponnusamy Vignesh , Gupta Sushilkumar S. , Raheja Hitesh , Patti Ravikaran , Soni Parita , Malhan Namrita , Lin Yu Shia , Kupfer Yizhak
Published: July 2019

Human metapneumo virus is an emerging cause of upper and lower respiratory tract illness with increasing reports of a varied spectrum of disease over all age groups. We report an outbreak of 6 cases of human metapneumo virus infection in the intensive care unit of a metropolitan tertiary care center over 6 weeks, leading to severe acute respiratory distress syndrome. We report the subsequent favorable outcomes due to the institution of extracorporeal membrane oxygenation.
Catching Lipid Droplet Contacts by Proteomics
Authors: Krahmer Natalie , Mann Matthias
Published: July 2019

Lipid droplets (LDs), important organelles for energy storage and involved in the development of metabolic disorders, are extremely dynamic and interact with many other cellular compartments to orchestrate lipid metabolism. Little is known about how these organelle contacts are changed according to cellular needs and functions under different metabolic and pathological conditions and which proteins regulate this. Here, we summarize recent exciting discoveries about the reorganization of organelle contacts in steatotic liver, including the identification of novel LD contact site proteins in cell lines and in animals. We also discuss state of the art proteomics workflows that enable the characterization of LD-organelle contacts and tethering proteins and give an outlook how this can inform obesity research.
Managing Software Development Projects for Success: Aligning Plan- and Agility-Based Approaches to Project Complexity and Project Dynamism
Authors: Butler Charles W. , Vijayasarathy Leo R. , Roberts Nicholas
Published: July 2019

In general, project complexity and project dynamism are recognized as potent characteristics that influence, usually in a negative way, the outcome of software development projects. However, with respect to the two dominant paradigms for managing software development projects (i.e., plan-based project approach and agility-based project approach), there is less agreement as to which one is better. Emerging research suggests that the preeminence of one approach over another is a matter of fit between the project management approach and the project context, including its complexity and dynamism. We contribute to this line of research by studying the moderating influence of the two project management approaches on the relationship between project complexity and project dynamism on project outcomes. Our analysis of data gathered from a survey of software development professionals shows that managing dynamism is critical for realizing project success, and an agility-based project approach is best suited for mitigating dynamism’s negative effects on project success.
Exhaled volatile organic compounds in adult asthma: a systematic review
Authors: Azim Adnan , Barber Clair , Dennison Paddy , Riley John , Howarth Peter
Published: July 2019

The search for biomarkers that can guide precision medicine in asthma, particularly those that can be translated to the clinic, has seen recent interest in exhaled volatile organic compounds (VOCs). Given the number of studies reporting “breathomics” findings and its growing integration in clinical trials, we performed a systematic review of the literature to summarise current evidence and understanding of breathomics technology in asthma.

A PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses)-oriented systematic search was performed (CRD42017084145) of MEDLINE, Embase and the Cochrane databases to search for any reports that assessed exhaled VOCs in adult asthma patients, using the following terms (asthma AND (volatile organic compounds AND exhaled) OR breathomics).

Two authors independently determined the eligibility of 2957 unique records, of which 66 underwent full-text review. Data extraction and risk of bias assessment was performed on the 22 studies deemed to fulfil the search criteria. The studies are described in terms of methodology and the evidence narratively summarised under the following clinical headings: diagnostics, phenotyping, treatment stratification, treatment monitoring and exacerbation prediction/assessment.

Our review found that most studies were designed to assess diagnostic potential rather than focus on underlying biology or treatable traits. Results are generally limited by a lack of methodological standardisation and external validation and by insufficiently powered studies, but there is consistency across the literature that exhaled VOCs are sensitive to underlying inflammation. Modern studies are applying robust breath analysis workflows to large multi-centre study designs, which should unlock the full potential of measurement of exhaled volatile organic compounds in airways diseases such as asthma.
Plasma mitochondrial DNA is associated with extrapulmonary sarcoidosis
Authors: Ryu Changwan , Brandsdorfer Caitlin , Adams Taylor , Hu Buqu , Kelleher Dylan W. , Yaggi Madeleine , Manning Edward P. , Walia Anjali , Reeves Benjamin , Pan Hongyi , Winkler Julia , Minasyan Maksym , Dela Cruz Charles S. , Kaminski Naftali , Gulati Mridu , Herzog Erica L.
Published: July 2019

Sarcoidosis is an unpredictable granulomatous disease in which African Americans disproportionately experience aggressive phenotypes. Mitochondrial DNA (mtDNA) released by cells in response to various stressors contributes to tissue remodelling and inflammation. While extracellular mtDNA has emerged as a biomarker in multiple diseases, its relevance to sarcoidosis remains unknown. We aimed to define an association between extracellular mtDNA and clinical features of sarcoidosis.

Extracellular mtDNA concentrations were measured using quantitative PCR for the humanMT-ATP6gene in bronchoalveolar (BAL) and plasma samples from healthy controls and patients with sarcoidosis from The Yale Lung Repository; associations betweenMT-ATP6concentrations and Scadding stage, extrapulmonary disease and demographics were sought. Results were validated in the Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis cohort.

Relative to controls,MT-ATP6concentrations in sarcoidosis subjects were robustly elevated in the BAL fluid and plasma, particularly in the plasma of patients with extrapulmonary disease. Relative to Caucasians, African Americans displayed excessiveMT-ATP6concentrations in the BAL fluid and plasma, for which the latter compartment correlated with significantly higher odds of extrapulmonary disease.

Enrichments in extracellular mtDNA in sarcoidosis are associated with extrapulmonary disease and African American descent. Further study into the mechanistic basis of these clinical findings may lead to novel pathophysiologic and therapeutic insights.
Accurate seismic dip and azimuth estimation using semblance dip guided structure tensor analysis
Authors: Lou Yihuai , Zhang Bo , Lin Tengfei , Liu Naihao , Wu Hao , Liu Rongchang , Cao Danping
Published: July 2019

Seismic volumetric dip and azimuth are widely used in assisting seismic interpretation to depict geologic structures such as chaotic slumps, fans, faults, and unconformities. Current popular dip and azimuth estimation methods include the semblance-based multiple window scanning (MWS) method and gradient structure tensor (GST) analysis. However, the dip estimation accuracy using the semblance scanning method is affected by the dip of seismic reflectors. The dip estimation accuracy using the GST analysis is affected by the analysis window centered at the analysis point. We have developed a new algorithm to overcome the disadvantages of dip estimation using MWS and GST analysis by combining and improving the two methods. The algorithm first obtains an estimated “rough” dip and azimuth for reflectors using the semblance scanning method. Then, the algorithm defines a window that is “roughly” parallel to the local reflectors using the estimated rough dip and azimuth. The algorithm next estimates the dip and azimuth of the reflectors within the analysis window using GST analysis. To improve the robustness of GST analysis to noise, we used analytic seismic traces to compute the GST matrix. The algorithm finally uses the Kuwahara window strategy to determine the dip and azimuth of local reflectors. To illustrate the superiority of this algorithm, we applied it to the F3 block poststack seismic data acquired in the North Sea, Netherlands. The comparison indicates that the seismic volumetric dips estimated using our method more accurately follow the local seismic reflectors than the dips computed using GST analysis and the semblance-based MWS method.
Fast 3D magnetic inversion of a surface relief in the space domain
Authors: Hidalgo-Gato Marlon C. , Barbosa Valéria C. F.
Published: July 2019

We have developed a fast 3D regularized magnetic inversion algorithm for depth-to-basement estimation based on an efficient way to compute the total-field anomaly produced by an arbitrary interface separating nonmagnetic sediments from a magnetic basement. We approximate the basement layer by a grid of 3D vertical prisms juxtaposed in the horizontal directions, in which the prisms’ tops represent the depths to the magnetic basement. To compute the total-field anomaly produced by the basement relief, the 3D integral of the total-field anomaly of a prism is simplified by a 1D integral along the prism thickness, which in turn is multiplied by the horizontal area of the prism. The 1D integral is calculated numerically using the Gauss-Legendre quadrature produced by dipoles located along the vertical axis passing through the prism center. This new magnetic forward modeling overcomes one of the main drawbacks of the nonlinear inverse problem for estimating the basement depths from magnetic data: the intense computational cost to calculate the total-field anomaly of prisms. The new sensitivity matrix is simpler and computationally faster than the one using classic magnetic forward modeling based on the 3D integrals of a set of prisms that parameterize the earth’s subsurface. To speed up the inversion at each iteration, we used the Gauss-Newton approximation for the Hessian matrix keeping the main diagonal only and adding the first-order Tikhonov regularization function. The large sparseness of the Hessian matrix allows us to construct and solve a linear system iteratively that is faster and demands less memory than the classic nonlinear inversion with prism-based modeling using 3D integrals. We successfully inverted the total-field anomaly of a simulated smoothing basement relief with a constant magnetization vector. Tests on field data from a portion of the Pará-Maranhão Basin, Brazil, retrieved a first depth-to-basement estimate that was geologically plausible.
Induced polarization response of porous media with metallic particles — Part 9: Influence of permafrost
Authors: Revil André , Razdan Mridul , Julien Stéphane , Coperey Antoine , Abdulsamad Feras , Ghorbani Ahmad , Gasquet Dominique , Sharma Ravi , Rossi Magali
Published: July 2019

We consider a mixture made of dispersed metallic particles immersed into a background material saturated by an electrolyte. Below the freezing temperature (typically 0°C to [Formula: see text]), a fraction of the liquid water in the pore space is transformed into ice, whereas the salt remains segregated into the liquid-pore water solution. Our goal is to understand how freezing affects the complex conductivity (induced polarization) of such mixtures. Complex conductivity measurements (96 spectra) are performed in a temperature-controlled bath equipped with a high-precision impedance meter. We cover the temperature range from [Formula: see text] to [Formula: see text] to [Formula: see text] and the frequency range from [Formula: see text] to 45 kHz. The spectra are fitted with a double Cole-Cole complex conductivity model. A finite-element model is used to further analyze the mechanisms of polarization by considering an intragrain polarization mechanism for the metallic particles and a change of the conductivity of the background material modeled with an exponential freezing curve. This curve is used to relate the liquid water content to the temperature. In the context of freezing, we test all the aspects of the intragrain polarization model developed in the previous papers of this series, at least for a weakly polarizable background material. The Cole-Cole exponent and the chargeability are observed to be essentially independent of temperature including in freezing conditions. This means that all the relaxation times of the system follow the same temperature dependence and that the chargeability is controlled by the volume fraction of metal. The instantaneous conductivity (high-frequency conductivity) and the relaxation times depend on the temperature in a predictable way, and their product can be considered to be essentially temperature independent. The analytical and numerical models can reproduce the inverse relationship between the relaxation time and the instantaneous conductivity.
Assessing the performances of recent global search algorithms using analytic objective functions and seismic optimization problems
Authors: Aleardi Mattia , Pierini Silvio , Sajeva Angelo
Published: July 2019

We have compared the performances of six recently developed global optimization algorithms: imperialist competitive algorithm, firefly algorithm (FA), water cycle algorithm (WCA), whale optimization algorithm (WOA), fireworks algorithm (FWA), and quantum particle swarm optimization (QPSO). These methods have been introduced in the past few years and have found very limited or no applications to geophysical exploration problems thus far. We benchmark the algorithms’ results against the particle swarm optimization (PSO), which is a popular and well-established global search method. In particular, we are interested in assessing the exploration and exploitation capabilities of each method as the dimension of the model space increases. First, we test the different algorithms on two multiminima and two convex analytic objective functions. Then, we compare them using the residual statics corrections and 1D elastic full-waveform inversion, which are highly nonlinear geophysical optimization problems. Our results demonstrate that FA, FWA, and WOA are characterized by optimal exploration capabilities because they outperform the other approaches in the case of optimization problems with multiminima objective functions. Differently, QPSO and PSO have good exploitation capabilities because they easily solve ill-conditioned optimizations characterized by a nearly flat valley in the objective function. QPSO, PSO, and WCA offer a good compromise between exploitation and exploration.
Retinoic acid signaling pathways
Authors: Ghyselinck Norbert B. , Duester Gregg
Published: July 2019

Retinoic acid (RA), a metabolite of retinol (vitamin A), functions as a ligand for nuclear RA receptors (RARs) that regulate development of chordate animals. RA-RARs can activate or repress transcription of key developmental genes. Genetic studies in mouse and zebrafish embryos that are deficient in RA-generating enzymes or RARs have been instrumental in identifying RA functions, revealing that RA signaling regulates development of many organs and tissues, including the body axis, spinal cord, forelimbs, heart, eye and reproductive tract. An understanding of the normal functions of RA signaling during development will guide efforts for use of RA as a therapeutic agent to improve human health. Here, we provide an overview of RA signaling and highlight its key functions during development.
Yap/Taz-TEAD activity links mechanical cues to progenitor cell behavior during zebrafish hindbrain segmentation
Authors: Voltes Adrià , Hevia Covadonga F. , Engel-Pizcueta Carolyn , Dingare Chaitanya , Calzolari Simone , Terriente Javier , Norden Caren , Lecaudey Virginie , Pujades Cristina
Published: July 2019

Cells perceive their microenvironment through chemical and physical cues. However, how the mechanical signals are interpreted during embryonic tissue deformation to result in specific cell behaviors is largely unknown. The Yap/Taz family of transcriptional co-activators has emerged as an important regulator of tissue growth and regeneration, responding to physical cues from the extracellular matrix, and to cell shape and actomyosin cytoskeletal changes. In this study, we demonstrate the role of Yap/Taz-TEAD activity as a sensor of mechanical signals in the regulation of the progenitor behavior of boundary cells during zebrafish hindbrain compartmentalization. Monitoring of in vivo Yap/Taz activity during hindbrain segmentation indicated that boundary cells responded to mechanical cues in a cell-autonomous manner through Yap/Taz-TEAD activity. Cell-lineage analysis revealed that Yap/Taz-TEAD boundary cells decreased their proliferative activity when Yap/Taz-TEAD activity ceased, which preceded changes in their cell fate from proliferating progenitors to differentiated neurons. Functional experiments demonstrated the pivotal role of Yap/Taz-TEAD signaling in maintaining progenitor features in the hindbrain boundary cell population.
Extracellular Hsp90α and clusterin synergistically promote breast cancer epithelial-to-mesenchymal transition and metastasis via LRP1
Authors: Tian Yang , Wang Chunying , Chen Shuohua , Liu Jie , Fu Yan , Luo Yongzhang
Published: July 2019

Extracellular heat shock protein 90 alpha (eHsp90α, also known as HSP90AA1) has been widely reported to promote tumor cell motility and tumor metastasis in various types of cancer. Several extracellular proteins and membrane receptors have been identified as interacting proteins of eHsp90α and mediate its pro-metastasis function. However, the regulatory mechanism of eHsp90α activity remains largely unknown. Here, we report that clusterin, a protein newly demonstrated to interact with eHsp90α, modulates eHsp90α signaling. We found that clusterin potentiated the effects of eHsp90α on activation of the AKT, ERK and NF-κB protein families, epithelial-to-mesenchymal transition (EMT) and migration in breast cancer cells. Furthermore, in vivo investigations demonstrated similar synergistic effects of eHsp90α and clusterin on tumor metastasis. Notably, the effects of eHsp90α and clusterin were mediated by low-density lipoprotein receptor-related protein 1 (LRP1). Proximity ligation assay and co-immunoprecipitation experiments demonstrated that clusterin participated in eHsp90α–LRP1 complex formation, which enhanced the binding affinity of eHsp90α to LRP1. Collectively, our data establish a role of clusterin as a newly discovered modulator of eHsp90α, and unravel detailed molecular mechanisms underlying the synergistic metastasis-promoting effects of clusterin and eHsp90α.
The protective effects of antigen-specific IgY on pyocyanin-treated human lymphoma Raji cells
Authors: Susilowati Heni , Artanto Sidna , Yulianto Heribertus Dedy Kusuma , Sosroseno Wihaskoro , Hutomo Suryani
Published: July 2019

Background:Pyocyanin (PCN), a highly pathogenic pigment produced byPseudomonas aeruginosa, induces caspase 3-dependent human B cell (Raji cells) death. The aim of the present study, therefore, was to assess whether antigen-specific IgY antibodies may be protective on PCN-induced Raji cell death.

Methods:Chickens were subcutaneously immunized with Freund's complete adjuvant containing PCN, and then given two boosted immunizations.  Anti-PCN IgY antibodies were purified from egg yolk and detected using an agar gel precipitation test (AGPT) and ELISA. Protective effects of antigen-specific IgY on Raji cells were tested using a cell viability assay.

Results:AGPT results showed the formation of strong immune complex precipitates, whilst ELISA further confirmed the presence of IgY antibodies specific to PCN at significant concentration. Further experiments showed that anti-PCN IgY antibodies significantly increased PCN-treated Raji cell viability in a dose-dependent fashion (p<0.05).

Conclusions:The results of the present study suggest that anti-PCN IgY antibodies may be protective on PCN-induced Raji cell death.
Large-scale sequence comparisons with sourmash
Authors: Pierce N. Tessa , Irber Luiz , Reiter Taylor , Brooks Phillip , Brown C. Titus
Published: July 2019

The sourmash software package uses MinHash-based sketching to create “signatures”, compressed representations of DNA, RNA, and protein sequences, that can be stored, searched, explored, and taxonomically annotated. sourmash signatures can be used to estimate sequence similarity between very large data sets quickly and in low memory, and can be used to search large databases of genomes for matches to query genomes and metagenomes. sourmash is implemented in C++, Rust, and Python, and is freely available under the BSD license at http://github.com/dib-lab/sourmash.
Implicational Logic, Relevance, and Refutability
Authors: Skura Tomasz
Published: July 2019

The goal of this paper is to analyse Implicational Relevance Logic from the point of view of refutability. We also correct an inaccuracy in our paper “The RM paraconsistent refutation system” (DOI: http://dx.doi.org/10.12775/LLP.2009.005).
Triangles, Tropes, and τὰ τοιαʋ ̃τα: A Platonic Trope Theory
Authors: Buckels Christopher
Published: July 2019

A standard interpretation of Plato’s metaphysics holds that sensible particulars are images of Forms. Such particulars are fairly independent, like Aristotelian substances. I argue that this is incorrect: Platonic particulars are not Form images but aggregates of Form images, which are property-instances (tropes). Timaeus 49e-50a focuses on “this-suches” (toiauta) and even goes so far as to claim that they compose other things. I argue that Form images are this-suches, which are tropes. I also examine the geometrical account, showing that the geometrical constituents of the elements are also Form images. Thus everything in the sensible world is composed of tropes.
What are the Objects of Dianoia?
Authors: Gerson Lloyd P.
Published: July 2019

In this paper, I examine the problem of the so-called Mathematical Objects within the context of the Divided Line. I argue that Plato believes that there are such objects but their distinctness and the mode of cognition relative to them can only be understood in relation to the superordinate, unhypothetical first principle of all, the Idea of the Good. The objects of mathematics or διάνοια are, unlike the objects of intellection or νόησις, cognized independently of the Good.
Unclarity and the Intermediates in Plato’s Discussions of Clarity in the Republic
Authors: Smith Nicholas
Published: July 2019

In this paper, I argue that the two versions of divided line (the first in Book VI and the recalled version in Book VII) create problems that cannot be solved — with or without the hypothesis that the objects belonging to the level of διάνοια on the divided line are intermediates.  I also argue that the discussion of arithmetic and calculation does not fit Aristotle’s attribution of intermediates to Plato and provides no support for the claim that Plato had such intermediates in mind when he talked about διάνοια in the Republic. The upshot of my argument is negative: even if Aristotle’s report about Plato and intermediates is correct, there is no evidence for such objects provided in the passages I review from the Republic. If they are to be found in Plato, it will have to be elsewhere that they are found.
Un rey viejo para tiempos nuevos: la construcción mediática del pretendiente Alfonso Carlos I en la prensa carlista durante la II República
Authors: Agudín Menéndez José Luis
Published: July 2019

En este artículo se pretende evaluar por medio de las páginas de diversas publicaciones adscritas a la red de prensa tradicionalista a lo largo del período 1931-1936 la imagen que las mismas se encargaron de transmitir del nuevo, aunque octogenario, rey-pretendiente carlista, Alfonso Carlos (1849-1936), quien encarnó el nuevo viraje de la Comunión Tradicionalista. Su presencia y la de otros componentes de la familia real legitimista aparecían una y otra vez en los medios periodísticos —al mismo tiempo que sus retratos presidían espacios de sociabilidad tradicionalistas—con motivo de sus manifiestos como cabeza de la forma no estatal carlista, las festividades, santorales o cumpleaños. En último término, se atenderá el tratamiento del dilema sucesorio que enfrentó en el campo de la ideología y la propaganda a las reunificadas facciones de la “amalgama contrarrevolucionaria”. De entre las cabeceras asociadas a la red periodística carlista se analizarán, entre otras, por su importancia: los anteriormente diarios integristas El Siglo Futuro y La Constancia, el bisemanario jaimista El Cruzado Español, la revista santanderina Tradición o las cabeceras vitorianas Heraldo y Pensamiento Alavés.
RECYCLING OF PINEAPPLE WASTE USING LACTOBACILLUS DELBROECKII TO LACTIC ACID
Authors: Moch Busairi Abdullah
Published: July 2019

Abdullah, in paper recycling of pineapple waste using lactobacillus delbroeckii to lactic acid, explain that The pineapple wastes juice contains mainly sucrose, glucose, fructose and other nutrients. It therefore can potentially be used as carbon source for organic acid fermentation. Recently, lactic acid has been considered to be an important raw material for production of biodegradable lactate polymer. The experiments were carried out in shake flask fermentation using Lactobacillus delbrueckii. Effect of some parameters such as temperature, initial pH, initial substrate concentration, yeast extract concentration and fermentation time to the yield have been studied. The highest yield was 85.65 % achieved at 40 o C, pH 6.00, 52.5 g/l sugar concentration with 5 g/l yeast extract. There was no significant increasing in lactic acid production was observed if supplementation of yeast extract above 10 %..
ANALISIS EFISIENSI PEMAKAINAN BAHAN BAKAR MESIN INDUK KAPAL PURSE SEINER DI PELABUHAN PENDARATAN NUSANTARA PEKALONGAN
Authors: Sa’id Solichin Djazuli
Published: July 2019

Solichin Djazuli Sa’id, in this paper explain that fuel consumption for each vessel were variations depending on the size of ships, ships with a larger size will require more fuel for each mile distance the ship with  a GT 101 for a distance of 1 mile with a speed of 6 knots require diesel fuel (dieselfue oil ) 6.24 liter, GT 1991: 6.06 liter, GT 80: 5.69 liter, GT 71: 5.13 liter, GT 61;4.74 liter and most economical is the GT 45 is only 3.30 liters per milnyaThe lowest operating costs of fishing vessels is to measure 45GT, 101GT highest. Operational Cost (OC) is the most economical ship with size 45 GT (Modern I).Operational costs are dominating the supply of fuel (diesel) 44%.Profit rate (profit rate) obtained by vessels of 45 GT (Modern I)  has a rate of returnabove 15%, the highest in comparison  with vessels of above. Keywords: Fuel consumption, operating costs
APLIKASI TAPIS PELEWAT RENDAH LC (LOW PASS LC FILTER) UNTUK MEREDUKSI DISTORSI HARMONISA PADA LAMPU HEMAT ENERGI
Authors: Sasmoko Priyo , Subali Subali , Yuwono Teguh
Published: July 2019

Priyo Sasmoko, Subali, Teguh Yuwono, in this paper explain that harmonic (current or voltage) is one of the problems that has to be solved in electric power system, especially that caused by non-linear loads. Harmonic could cause bad impacts for the electric components that sensed it. It is almost certain that using of fluorescent lamp with electronic ballast or it is called energy saving lamp can cause harmonic in electric power system. Considering of the using of energy saving lamp is increased fairly fast as residence and office lighting, so it is important to analyze and solve the harmonic that caused by energy saving lamp. From the harmonic analysis, we can know the harmonic distortion caused by energy saving lamp. And there are some efforts to reduce such harmonic distortion by using a Low Pass Filter. Keyword: power quality, harmonic, low pass filter.
PENGEMBANGAN ADSORBENT BED UNTUK PENINGKATAN KONDUKTIVITAS TERMAL MELALUI PENAMBAHAN PARTIKEL METAL ALUMINIUM
Authors: Ariwibowo Didik , Sutrisno Sutrisno
Published: July 2019

Didik Ariwibowo, Sutrisno, in this paper explain that this research is to increase thermal conductivity of a adsorbent bed by adding metal particles in it so that the bed become a granule-mixed bed. The adsorbent bed contains activated-carbon granule and aluminium particles. The research activity include: design and fabrication of adsorbent bed prototype following thermal performance study of the adsorbent bed. The thermal performance study of the adsorbent bed was conducted by varying metal/adsorbent ratio of 5%, 10%, 15% by volume. The result showed that adding 5%, 10%, and 15% aluminium particles into adsorbent bed has increased its thermal conductivity, those are 10,9 Wm-1K-1; 21,9 Wm-1K-1; and 30,9  Wm-1K-1 respectively from 1,6 Wm-1K-1 activated carbon thermal conductivity. The values of experimental thermal conductivity were higher than those of calculated thermal conductivity. The percentage of the difference between experimental thermal conductivity and calculated thermal conductivity decreased as bed surface temperature increased. The relatively higher percentage was in 45% whereas the lower was 10%. The lower range of the difference was 10-20% occurred in 55-65 oC temperature range. Key words: adsorbent bed, metal/adsorbent ratio, thermal conductivity