bluuebunny/crossref_metadata_2025 huggingface dataset:
Addressing Health Literacy in Schools in Germany: Concept Analysis of the Mandatory Digital and Media Literacy School Curriculum
Authors: Schulenkorf Tessa , Krah Verena , Dadaczynski Kevin , Okan Orkan
Published: July 2021

It is generally agreed upon that the development of health literacy should be addressed from an early age onwards in order to empower children to develop their full health potential. Schools can be seen as an ideal venue for strengthening health literacy because they reach almost all school-aged children throughout their school years. The development of health literacy at a young age is a catalyst for healthy development throughout across the life span. Evidence shows that health and education are intertwined with favorable effects for health (e.g., health behavior, knowledge) and education outcomes (e.g., academic achievement). However, health literacy is often not sufficiently integrated into the school curriculum despite its importance to health and education. Integrating health literacy into schools is challenging, as both schools and teachers already face numerous educational requirements that may prevent them from addressing health in the classroom because they perceive it as an additional task. This is why taking a sensitive approach is important, adapted to the needs of schools and highlighting the benefits of health literacy. Installing health literacy in schools succeeds more easily if it can be linked to existing curricular requirements. In this context, curriculum and instruction on media literacy, information literacy, and digital literacy are most promising subjects to include health literacy because these concepts share many commonalities with health literacy and often are already part of the school curriculum. The aim of this article is to (1) analyze a mandatory curriculum on media literacy in the state of North-Rhine-Westphalia in Germany, (2) highlight its intersections with health literacy, and (3) show how it can be used to address health literacy. The state media literacy framework is based on the federal standards for “digital education” developed by the German Conference on Education Ministries und Cultural Affairs (KMK). As education policy and practice is decentralized with sixteen federal states in Germany, each of them has got their own media literacy framework, or they are currently developing it. This curriculum analysis may serve as a methodological blueprint for educationalists, teachers, and policy-maker elsewhere in order to include health literacy into existing curricula both health and non-health. It may help to integrate health literacy into schools when combined with existing curricula.
Using Proper Mean Generation Intervals in Modeling of COVID-19
Authors: Tang Xiujuan , Musa Salihu S. , Zhao Shi , Mei Shujiang , He Daihai
Published: July 2021

In susceptible–exposed–infectious–recovered (SEIR) epidemic models, with the exponentially distributed duration of exposed/infectious statuses, the mean generation interval (GI, time lag between infections of a primary case and its secondary case) equals the mean latent period (LP) plus the mean infectious period (IP). It was widely reported that the GI for COVID-19 is as short as 5 days. However, many works in top journals used longer LP or IP with the sum (i.e., GI), e.g., >7 days. This discrepancy will lead to overestimated basic reproductive number and exaggerated expectation of infection attack rate (AR) and control efficacy. We argue that it is important to use suitable epidemiological parameter values for proper estimation/prediction. Furthermore, we propose an epidemic model to assess the transmission dynamics of COVID-19 for Belgium, Israel, and the United Arab Emirates (UAE). We estimated a time-varying reproductive number [R0(t)] based on the COVID-19 deaths data and we found that Belgium has the highest AR followed by Israel and the UAE.
Does Chronic Obstructive Pulmonary Disease Affect Workers' Health?
Authors: Yao Li-Peng , Tao Ran
Published: July 2021

During recent decades, the elevation of workers' health has become the utmost point of concern since it is considered among the primary indicators of economies. The economies, especially the emerging ones, are primarily focusing on every indicator to uplift their businesses. Along with the other aspects, it is also required to assess the impact of Chronic Obstructive Pulmonary Disease (COPD) on workers' health conditions in small- and medium-scale enterprises (SMEs). With this aim, we are presenting a detailed analysis to reveal useful insights regarding the COPD-workers' health nexus. The sample set of 1,008 workers is working in various SMEs in Beijing and Tianjin from September, 2020. The findings infer that a rise in COPD concerning wages will uplift the worker health problems due to COPD affecting worker health. Whereas, the working condition and tools, smoking years, and health safety training have a statistically adverse effect on workers' health concerning wages. The outcomes in terms of insights would be useful for planning future perspectives.
Molecular Update and Evolving Classification of Large B-Cell Lymphoma
Authors: Onaindia Arantza , Santiago-Quispe Nancy , Iglesias-Martinez Erika , Romero-Abrio Cristina
Published: July 2021

Diffuse large B-cell lymphomas (DLBCLs) are aggressive B-cell neoplasms with considerable clinical, biologic, and pathologic diversity. The application of high throughput technologies to the study of lymphomas has yielded abundant molecular data leading to the identification of distinct molecular identities and novel pathogenetic pathways. In light of this new information, newly refined diagnostic criteria have been established in the fourth edition of the World Health Organization (WHO) consensus classification of lymphomas, which was revised in 2016. This article reviews the histopathological and molecular features of the various aggressive B-cell lymphoma subtypes included in the updated classification.
Melatonin Treatment Improves Renal Fibrosis via miR-4516/SIAH3/PINK1 Axis
Authors: Yoon Yeo Min , Go Gyeongyun , Yoon Sungtae , Lim Ji Ho , Lee Gaeun , Lee Jun Hee , Lee Sang Hun
Published: July 2021

Dysregulation in mitophagy, in addition to contributing to imbalance in the mitochondrial dynamic, has been implicated in the development of renal fibrosis and progression of chronic kidney disease (CKD). However, the current understanding of the precise mechanisms behind the pathogenic loss of mitophagy remains unclear for developing cures for CKD. We found that miR-4516 is downregulated and its target SIAH3, an E3 ubiquitin protein ligase that reduces PINK1 accumulation to damaged mitochondria, is upregulated in the renal cortex of CKD mice. Here, we demonstrated that melatonin injection induces miR-4516 expression and suppresses SIAH3, and promotes PINK1/Parkin-mediated mitophagy. Furthermore, we demonstrated that melatonin injection attenuates the pathological features of CKD by improving mitochondrial homeostasis. Our data supports that mitochondrial autophagy regulation by activating miR-4516/SIAH3/PINK1 mitophagy signaling axis can be a viable new strategy for treating CKD.
Learning Numerosity Representations with Transformers: Number Generation Tasks and Out-of-Distribution Generalization
Authors: Boccato Tommaso , Testolin Alberto , Zorzi Marco
Published: July 2021

One of the most rapidly advancing areas of deep learning research aims at creating models that learn to disentangle the latent factors of variation from a data distribution. However, modeling joint probability mass functions is usually prohibitive, which motivates the use of conditional models assuming that some information is given as input. In the domain of numerical cognition, deep learning architectures have successfully demonstrated that approximate numerosity representations can emerge in multi-layer networks that build latent representations of a set of images with a varying number of items. However, existing models have focused on tasks requiring to conditionally estimate numerosity information from a given image. Here, we focus on a set of much more challenging tasks, which require to conditionally generate synthetic images containing a given number of items. We show that attention-based architectures operating at the pixel level can learn to produce well-formed images approximately containing a specific number of items, even when the target numerosity was not present in the training distribution.
Enhanced Random Forest Model for Robust Short-Term Photovoltaic Power Forecasting Using Weather Measurements
Authors: Massaoudi Mohamed , Chihi Ines , Sidhom Lilia , Trabelsi Mohamed , Refaat Shady S. , Oueslati Fakhreddine S.
Published: July 2021

Short-term Photovoltaic (PV) Power Forecasting (STPF) is considered a topic of utmost importance in smart grids. The deployment of STPF techniques provides fast dispatching in the case of sudden variations due to stochastic weather conditions. This paper presents an efficient data-driven method based on enhanced Random Forest (RF) model. The proposed method employs an ensemble of attribute selection techniques to manage bias/variance optimization for STPF application and enhance the forecasting quality results. The overall architecture strategy gathers the relevant information to constitute a voted feature-weighting vector of weather inputs. The main emphasis in this paper is laid on the knowledge expertise obtained from weather measurements. The feature selection techniques are based on local Interpretable Model-Agnostic Explanations, Extreme Boosting Model, and Elastic Net. A comparative performance investigation using an actual database, collected from the weather sensors, demonstrates the superiority of the proposed technique versus several data-driven machine learning models when applied to a typical distributed PV system.
Steam Turbine Rotor Stress Control through Nonlinear Model Predictive Control
Authors: Dettori Stefano , Maddaloni Alessandro , Galli Filippo , Colla Valentina , Bucciarelli Federico , Checcacci Damaso , Signorini Annamaria
Published: July 2021

The current flexibility of the energy market requires operating steam turbines that have challenging operation requirements such as variable steam conditions and higher number of startups. This article proposes an advanced control system based on the Nonlinear Model Predictive Control (NMPC) technique, which allows to speed up the start-up of steam turbines and increase the energy produced while maintaining rotor stress as a constraint variable. A soft sensor for the online calculation of rotor stress is presented together with the steam turbine control logic. Then, we present how the computational cost of the controller was contained by reducing the order of the formulation of the optimization problem, adjusting the scheduling of the optimizer routine, and tuning the parameters of the controller itself. The performance of the control system has been compared with respect to the PI Controller architecture fed by the soft sensor results and with standard pre-calculated curves. The control architecture was evaluated in a simulation exploiting actual data from a Concentrated Solar Power Plant. The NMPC technique shows an increase in performance, with respect to the custom PI control application, and encouraging results.
How Is Social Acceptance Reflected in National Renewable Energy Plans? Evidence from Three Wind-Rich Countries
Authors: Bout Celine , Gregg Jay Sterling , Haselip James , Ellis Geraint
Published: July 2021

This article contributes to discussions of the social acceptance of renewable energy (RE) by developing an analytical framework that considers three dimensions (community, market, and political-regulator) at three different scales (macro, meso, and micro). This framework is conceived in order to identify those dynamics that are potentially counterproductive to the energy transition and need further policy emphasis, as well as supporting those that demonstrate a positive impact. Using this framework, we critically reflect on the 2010 National Renewable Energy Action Plan (NREAP) policies of three European countries with high wind resources: Denmark, Ireland, and the UK. Within the RE policy landscapes of these three countries lies the contentious issue of social acceptance of wind power. The framework analysis reveals similar policy profiles for each country, characterized by a heavy focus on the market dimension at all scales, an effort to allow private business to steer the transition, and a low focus on the community dimension. In doing so, our research reveals how policy-making processes have privileged the voice of actors who are able to communicate quantifiable data and evidence to support their position, and these actors thereby have greater influence to shape national energy policies.
Identification of the Determinants of the Effectiveness of On-Road Chicanes in the Village Transition Zones Subject to a 50 km/h Speed Limit
Authors: Sołowczuk Alicja Barbara , Kacprzak Dominik
Published: July 2021

In recent years, in which a considerable increase in the road traffic volumes has been witnessed, traffic calming has become one the key issues in the area of road engineering. This concerns, in particular, trunk roads passing through small villages with a population of up to 500 and the road section length within the village limits of ca. 1400–1700 m. A successful traffic calming scheme must involve primarily effective reduction in inbound traffic speed. A review of the data from various countries revealed that chicanes installed in the transition zones may have a determining effect on the success of the traffic calming project. The effectiveness of such chicanes depends mainly on the type of chicane, its location on the carriageway, its shape and the size of the lateral deflection imposed by the chicane on the inbound lane. The purpose of this study was to identify the speed reduction determinants in traffic calming schemes in village transition zones, based on a central island horizontally deflecting one lane of a two-lane two-way road with 50 km/h speed restriction. As part of the study, vehicle speeds were measured just before and after the chicanes under analysis. Furthermore, the inbound lane traffic volumes were measured in field and a number of factors were identified, including the applied traffic management scheme, road parameters, view of the road ahead and of the village skyline, isolated buildings, road infrastructure and adjacent roadside developments. The obtained data were analysed with a method employing tautologies of the selected 32 factors affecting the drivers’ perception. A single aggregate parameter was proposed for assessing the coincidence of the influence of selected factors on speed reduction. The analysis of the existing schemes and the results of statistical analyses carried out in this study confirmed the authors’ hypothesis that the combined selected factors produce a desirable effect and that they should be additionally enhanced by the application of solar powered devices.
Hygrothermal and Acoustic Performance of Two Innovative Envelope Renovation Solutions Developed in the e-SAFE Project
Authors: Evola Gianpiero , Costanzo Vincenzo , Marletta Luigi
Published: July 2021

In order to reach the ambitious decarbonizing goals set by the European Union for 2030, deep renovation of the existing European building stock is a key issue. Within this context, the recently funded H2020 project “e-SAFE” is investigating market-ready wooden envelope renovation solutions for non-historic buildings, which encompass both energy and seismic improvement. The research carried out in the project aims at developing, testing and demonstrating these solutions on a real pilot. More specifically, this paper presents preliminary analyses to verify that the solutions satisfy the requisites set by the national regulations in force in most European countries, in terms of hygrothermal and acoustic performance. The analysis, carried out following relevant technical European Standards and based on calculations, considers different climate conditions and existing wall structures, selected amongst those most commonly adopted in Europe. The results show that the addition of a Cross Laminated Timber (CLT) layer with some wooden-based insulation on the outer side allows reaching very good thermal and acoustic performance. However, interstitial condensation may occur in cold climates under high indoor humidity values. This aspect deserves further investigation accounting for the transient behavior of the walls and all vapor transport mechanisms.
Centralized and Decentralized Optimal Control of Variable Speed Heat Pumps
Authors: Montrose Ryan S. , Gardner John F. , Satici Aykut C.
Published: July 2021

Utility service providers are often challenged with the synchronization of thermostatically controlled loads. Load synchronization, as a result of naturally occurring and demand-response events, has the potential to damage power distribution equipment. Because thermostatically controlled loads constitute most of the power consumed by the grid at any given time, the proper control of such devices can lead to significant energy savings and improved grid stability. The contribution of this paper is the development of an optimal control algorithm for commonly used variable speed heat pumps. By means of selective peer-to-peer communication, our control architecture allows for the regulation of home temperatures while simultaneously minimizing aggregate power consumption, and aggregate load volatility. An optimal centralized controller is also explored and compared against its decentralized counterpart.
Optimization of Costs and Self-Sufficiency for Roof Integrated Photovoltaic Technologies on Residential Buildings
Authors: Mutani Guglielmina , Todeschi Valeria
Published: July 2021

It is common practice, in the production of photovoltaic energy to only use the south-exposed roof surface of a building, in order to achieve the maximum production of solar energy while lowering the costs of the energy and the solar technologies. However, using the south-exposed surface of a roof only allows a small quota of the energy demand to be covered. Roof surfaces oriented in other directions could also be used to better cover the energy load profile. The aim of this work is to investigate the benefits, in terms of costs, self-sufficiency and self-consumption, of roof integrated photovoltaic technologies on residential buildings with different orientations. A cost-optimal analysis has been carried out taking into account the economic incentives for a collective self-consumer configuration. It has emerged, from this analysis, that the better the orientation is, the higher the energy security and the lower the energy costs and those for the installation of photovoltaic technologies. In general, the use of south-facing and north-facing roof surfaces for solar energy production has both economic and energy benefits. The self-sufficiency index can on average be increased by 8.5% through the use of photovoltaic installations in two directions on gable roofs, and the maximum level that can be achieved was on average 41.8, 41.5 and 35.7% for small, medium and large condominiums, respectively. Therefore, it could be convenient to exploit all the potential orientations of photovoltaic panels in cities to improve energy security and to provide significant economic benefits for the residential users.
Numerical Simulation of a Novel Dual Layered Phase Change Material Brick Wall for Human Comfort in Hot and Cold Climatic Conditions
Authors: Rehman Atiq Ur , Sheikh Shakil R. , Kausar Zareena , McCormack Sarah J.
Published: July 2021

Phase change materials (PCMs) have a large number of applications for thermal energy storage (TES) and temperature reduction in buildings due to their thermal characteristics and latent heat storage capabilities. The thermal mass of typical brick walls can be substantially increased using a suitable PCM primarily based on phase change temperature and heat of fusion for different weather conditions in summer and winter. This study proposed a novel dual-layer PCM configuration for brick walls to maintain human comfort for hot and cold climatic conditions in Islamabad, Pakistan. Numerical simulations were performed using Ansys Fluent for dual PCMs layered within a brick wall for June and January with melting temperatures of 29 °C and 13 °C. This study examined and discussed the charging and discharging cycles of PCMs over an extended period (one month) to establish whether the efficacy of PCMs is hindered due to difficulties in discharging. The results show that the combined use of both PCMs stated above provides better human comfort with reduced energy requirements in Islamabad throughout the year than using a single PCM (29 °C) for summer or winter (13 °C) alone.
Economic Optimization of Rotary Heat Exchangers Using CO2 Pricing Scenarios Based on Validated Fluid Dynamic and Thermodynamic-Based Simulation
Authors: Melian Eloy , Klein Harald , Thißen Nikolaus
Published: July 2021

Rotary heat exchangers have been widely used in paint shops, combustion power plants, and in heating, ventilation, and air conditioning systems in buildings. For these processes, many types of heat exchangers are available in the market: Tube-shell heat exchangers, plate heat exchangers, and rotary heat exchangers, among others. For the rotary heat exchangers, the problem is that there is no net present value method and lifecycle assessment method-based optimization found in the literature. In this work, we address this issue: An optimization is carried out with help of an empirically validated simulation model, a life-cycle assessment model, an economical assessment, and an optimization algorithm. The objective function of the optimization simultaneously considers economic and environmental aspects by using different CO2 pricing. Different CO2 pricing scenarios lead to different optimization results. The ambient air empty tube velocity va, 2.1 optimum was found at 1.2 m/s, which corresponds to a specific mass flow msp of 5.4 kg/(m2·h). For the wave angle β, the optimum was found in the range between 58° and 60°. For the wave height h* the optimum values were found to be between 2.64 mm and 2.77 mm. Finally, for the rotary heat exchanger length l, the optimum was found to be between 220 mm and 236 mm. The optimization results show that there is still potential for technical improvements in the design and operation of rotary heat exchangers. In general terms, we recommend that the optimized rotary heat exchanger should cause less pressure drop while resulting in similar heat recovery efficiency. This is because the life cycle assessment shows that the use phase for rotary heat exchangers has the biggest impact on greenhouse gases, specifically by saving on Scope 2 emissions.
An Improved Accessibility-Based Model to Evaluate Educational Equity: A Case Study in the City of Wuhan
Authors: Wang Yiheng , Liu Yaolin , Xing Lijun , Zhang Ziyi
Published: July 2021

Limited studies focus on educational equity from the spatial accessibility perspective. This study combines survey data and big data and proposes a multi-mode Huff two-step floating catchment area (MMH2SFCA) method to calculate accessibility while considering multiple travel modes and school attractiveness. This method can also calculate education quality by extending the accessibility in each community. Results show that our proposed method can reliably identify the accessibility differences of schools across communities. The case study indicates an inequitable distribution of educational accessibility and quality. The communities with high accessibility are concentrated in the urban center and exurban zones surrounding schools, whereas high-quality areas are mainly concentrated in the urban center. Correlation analysis suggests that the educational quality of communities with high accessibility is not always high. The findings of this study can provide improvement for accessibility measurements and help explore a new research perspective for educational equity research.
Bisphenol A Modulates Autophagy and Exacerbates Chronic Kidney Damage in Mice
Authors: Priego Alberto Ruiz , Parra Emilio González , Mas Sebastián , Morgado-Pascual José Luis , Ruiz-Ortega Marta , Rayego-Mateos Sandra
Published: July 2021

BACKGROUND: Bisphenol A (BPA) is a ubiquitous environmental toxin that accumulates in chronic kidney disease (CKD). Our aim was to explore the effect of chronic exposition of BPA in healthy and injured kidney investigating potential mechanisms involved. METHODS: In C57Bl/6 mice, administration of BPA (120 mg/kg/day, i.p for 5 days/week) was done for 2 and 5 weeks. To study BPA effect on CKD, a model of subtotal nephrectomy (SNX) combined with BPA administration for 5 weeks was employed. In vitro studies were done in human proximal tubular epithelial cells (HK-2 line). RESULTS: Chronic BPA administration to healthy mice induces inflammatory infiltration in the kidney, tubular injury and renal fibrosis (assessed by increased collagen deposition). Moreover, in SNX mice BPA exposure exacerbates renal lesions, including overexpression of the tubular damage biomarker Hepatitis A virus cellular receptor 1 (Havcr-1/KIM-1). BPA upregulated several proinflammatory genes and increased the antioxidant response [Nuclear factor erythroid 2-related factor 2 (Nrf2), Heme Oxygenase-1 (Ho-1) and NAD(P)H dehydrogenase quinone 1 (Nqo-1)] both in healthy and SNX mice. The autophagy process was modulated by BPA, through elevated autophagy-related gene 5 (Atg5), autophagy-related gene 7 (Atg7), Microtubule-associated proteins 1A/1B light chain 3B (Map1lc3b/Lc3b) and Beclin-1 gene levels and blockaded the autophagosome maturation and flux (p62 levels). This autophagy deregulation was confirmed in vitro. CONCLUSIONS: BPA deregulates autophagy flux and redox protective mechanisms, suggesting a potential mechanism of BPA deleterious effects in the kidney.
Midazolam’s Effects on Delayed-Rectifier K+ Current and Intermediate-Conductance Ca2+-Activated K+ Channel in Jurkat T-lymphocytes
Authors: Foo Ning-Ping , Liu Yu-Fan , Wu Ping-Ching , Hsing Chung-Hsi , Huang Bu-Miin , So Edmund-Cheung
Published: July 2021

Midazolam (MDZ) could affect lymphocyte immune functions. However, the influence of MDZ on cell’s K+ currents has never been investigated. Thus, in the present study, the effects of MDZ on Jurkat T lymphocytes were studied using the patch-clamp technique. Results showed that MDZ suppressed the amplitude of delayed-rectifier K+ current (IK(DR)) in concentration-, time-, and state-dependent manners. The IC50 for MDZ-mediated reduction of IK(DR) density was 5.87 μM. Increasing MDZ concentration raised the rate of current-density inactivation and its inhibitory action on IK(DR) density was estimated with a dissociation constant of 5.14 μM. In addition, the inactivation curve of IK(DR) associated with MDZ was shifted to a hyperpolarized potential with no change on the slope factor. MDZ-induced inhibition of IK(DR) was not reversed by flumazenil. In addition, the activity of intermediate-conductance Ca2+-activated K+ (IKCa) channels was suppressed by MDZ. Furthermore, inhibition by MDZ on both IK(DR) and IKCa-channel activity appeared to be independent from GABAA receptors and affected immune-regulating cytokine expression in LPS/PMA-treated human T lymphocytes. In conclusion, MDZ suppressed current density of IK(DR) in concentration-, time-, and state-dependent manners in Jurkat T-lymphocytes and affected immune-regulating cytokine expression in LPS/PMA-treated human T lymphocytes.
Molecular Research in Cardiovascular Disease
Authors: Dorobantu Maria , Simionescu Maya , Popa-Fotea Nicoleta-Monica
Published: July 2021

Cardiovascular diseases have attracted our full attention not only because they are the main cause of mortality and morbidity in many countries but also because the therapy for and cure of these maladies are among the major challenges of the medicine in the 21st century [...]
Circulating Endothelial Progenitor Cells Are Preserved in Female Mice Exposed to Ambient Fine Particulate Matter Independent of Estrogen
Authors: Liu Xuanyou , Xiao Yichao , Zhu Qingyi , Cui Yuqi , Hao Hong , Wang Meifang , Cowan Peter J. , Korthuis Ronald J. , Li Guangfu , Sun Qinghua , Liu Zhenguo
Published: July 2021

Males have a higher risk for cardiovascular diseases (CVDs) than females. Ambient fine particulate matter (PM) exposure increases CVD risk with increased reactive oxygen species (ROS) production and oxidative stress. Endothelial progenitor cells (EPCs) are important to vascular structure and function and can contribute to the development of CVDs. The aims of the present study were to determine if sex differences exist in the effect of PM exposure on circulating EPCs in mice and, if so, whether oxidative stress plays a role. Male and female C57BL/6 mice (8–10 weeks old) were exposed to PM or a vehicle control for six weeks. ELISA analysis showed that PM exposure substantially increased the serum levels of IL-6 and IL-1β in both males and females, but the concentrations were significantly higher in males. PM exposure only increased the serum levels of TNF-α in males. Flow cytometry analysis demonstrated that ROS production was significantly increased by PM treatment in males but not in females. Similarly, the level of circulating EPCs (CD34+/CD133+ and Sca-1+/Flk-1+) was significantly decreased by PM treatment in males but not in females. Antioxidants N-acetylcysteine (NAC) effectively prevented PM exposure-induced ROS and inflammatory cytokine production and restored circulating EPC levels in male mice. In sharp contrast, circulating EPC levels remained unchanged in female mice with PM exposure, an effect that was not altered by ovariectomy. In conclusion, PM exposure selectively decreased the circulating EPC population in male mice via increased oxidative stress without a significant impact on circulating EPCs in females independent of estrogen.
Perioperative Systemic Treatment for Muscle-Invasive Bladder Cancer: Current Evidence and Future Perspectives
Authors: Kim In-Ho , Lee Hyo-Jin
Published: July 2021

Radical cystectomy is the primary treatment for muscle-invasive bladder cancer; however, approximately 50% of patients develop metastatic disease within 2 years of diagnosis, which results in dismal prognosis. Therefore, systemic treatment is important to improve the prognosis of muscle-invasive bladder cancer. Currently, several guidelines recommend cisplatin-based neoadjuvant chemotherapy before radical cystectomy, and adjuvant chemotherapy is recommended in patients who have not received neoadjuvant chemotherapy. Immune checkpoint inhibitors have recently become the standard treatment option for metastatic urothelial carcinoma. Owing to their clinical benefits, several immune checkpoint inhibitors, with or without other agents (including other immunotherapy, cytotoxic chemotherapy, and emerging agents such as antibody drug conjugates), are being extensively investigated in perioperative settings. Several studies for perioperative immunotherapy have shown that immune checkpoint inhibitors have promising efficacy with relatively low toxicity, and have explored the predictive molecular biomarkers. Herein, we review the current evidence and discuss the future perspectives of perioperative systemic treatment for muscle-invasive bladder cancer.
The Abscopal Effect in the Era of Checkpoint Inhibitors
Authors: Kodet Ondřej , Němejcova Kristýna , Strnadová Karolína , Havlínová Andrea , Dundr Pavel , Krajsová Ivana , Štork Jiří , Smetana Karel , Lacina Lukáš
Published: July 2021

Therapy targeting immune checkpoints represents an integral part of the treatment for patients suffering from advanced melanoma. However, the mechanisms of resistance are responsible for a lower therapeutic outcome than expected. Concerning melanoma, insufficient stimulation of the immune system by tumour neoantigens is a likely explanation. As shown previously, radiotherapy is a known option for increasing the production of tumour neoantigens and their release into the microenvironment. Consequently, neoantigens could be recognized by antigen presenting cells (APCs) and subjected to effector T lymphocytes. Enhancing the immune reaction can trigger the therapeutic response also at distant metastases, a phenomenon known as an abscopal effect (from “ab scopus”, that is, away from the target). To illustrate this, we present the case of a 78-year old male treated by anti-CTLA-4/ipilimumab for metastatic melanoma. The patient received the standard four doses of ipilimumab administered every three weeks. However, the control CT scans detected disease progression in the form of axillary lymph nodes metastasis and liver metastasis two months after ipilimumab. At this stage, palliative cryotherapy of the skin metastases was initiated to alleviate the tumour burden. Surprisingly, the effect of cryotherapy was also observed in untreated metastases and deep subcutaneous metastases on the back. Moreover, we observed the disease remission of axillary lymph nodes and liver metastasis two months after the cryotherapy. The rarity of the abscopal effect suggests that even primed anti-tumour CD8+ T cells cannot overcome the tumour microenvironment’s suppressive effect and execute immune clearance. However, the biological mechanism underlying this phenomenon is yet to be elucidated. The elicitation of a systemic response by cryotherapy with documented abscopal effect was rarely reported, although the immune response induction is presumably similar to a radiotherapy-induced one. The report is a combination case study and review of the abscopal effect in melanoma treated with checkpoint inhibitors.
Conventional and Unconventional Approaches for Innovative Drug Treatments in COVID-19: Looking Outside of Plato’s Cave
Authors: Kontoghiorghes George J. , Kolnagou Annita , Fetta Stella , Kontoghiorghe Christina N.
Published: July 2021

Thousands of drugs and nutraceuticals along with their combinations can be used to select candidate therapeutics for targeting the transmission, proliferation and the fatal or severe symptoms of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in order to reduce the unacceptably high mortality rate observed in the coronavirus disease 2019 (COVID-19) pandemic and its associated negative effects on daily life worldwide [...]
Enhanced Electroplasticity through Room-Temperature Dynamic Recrystallization in a Mg-3Al-1Sn-1Zn Alloy
Authors: Xu Hong , Zou Yu-Jie , Huang Yu , Ma Pin-Kui , Guo Zhi-Peng , Zhou You , Wang Yu-Peng
Published: July 2021

It has been well known that electric pulse can be utilized to enhance the plasticity of metals, which is attributed to the change of dislocation dynamics, e.g., localized planar slip to homogeneous wavy slip. Here, we show another effect of pulse current, which facilitates texture weakening through room-temperature dynamic recrystallization and additionally improve the plasticity of a polycrystalline Mg-3Al-1Sn-1Zn alloy. By conducting a tensile test under electrical pulse, we found that the peak flow stress and fracture strain depend strongly on current density. As peak current densities increases, the flow stress drops and the fracture strain increases. Our Electron Backscatter Diffraction results suggest that dynamic recrystallization occurs at room temperature, which develops a weakened texture. Our work provides a new insight into electroplasticity mechanism in Mg alloys.
Dye-Sensitized Solar Cell for Building-Integrated Photovoltaic (BIPV) Applications
Authors: Szindler Marek , Szindler Magdalena , Drygała Aleksandra , Lukaszkowicz Krzysztof , Kaim Paulina , Pietruszka Rafał
Published: July 2021

One of the important research directions in the field of photovoltaics is integration with construction. The integration of solar cell systems with a building can reduce installation costs and help optimize the used space. Among the few literature reports on photovoltaic roof tiles, solutions with silicon and thin film solar cells dominate. An interesting solution may be the application of dye-sensitized solar cells. In addition to their interesting properties, they also have aesthetic value. In the classic arrangement, they are constructed using glass with a transparent conductive layer (TCL). This article describes replacing a classic glass counter electrode with an electrode based on a ceramic tile and nickel foil. First, a continuous and homogeneous fluorine-doped tin oxide (FTO) thin film was developed so that the above-mentioned substrate could be applied. The atomization method was used for this purpose. Then, nanocolloidal platinum paste was deposited as a catalytic material using the screen printing method. The electrical parameters of the manufactured DSSCs with and without a counter electrode tile were characterized by measuring their current–voltage characteristics under standard AM 1.5 radiation. A dye-sensitized solar cell integrated with ceramic tiles and nickel foil was produced and displayed an efficiency of over 4%. This solution makes it possible to expand their construction applications. The advantage of this solution is full integration with construction, while simultaneously generating electricity. A dye-sensitized solar cell was built layer-by-layer on a ceramic tile and nickel foil.
Angle of Insertion and Torsional Resistance of Nickel–Titanium Rotary Instruments
Authors: Di Nardo Dario , Zanza Alessio , Seracchiani Marco , Donfrancesco Orlando , Gambarini Gianluca , Testarelli Luca
Published: July 2021

Previously published studies have investigated the influence of instrument access on cyclic fatigue resistance. However, no studies have evaluated the relationship between angulated access and torsional resistance. The aim of this study was to investigate the influence of the angle of access on the torsional resistance of endodontic instruments. One hundred and eighty instruments were selected: 90 F-One Blue 25/04 and 90 HeroShaper 25/04 instruments. Three subgroups (n = 30) for each instrument type (A and B) were established according to the angle of insertion of the instruments inside the artificial canal (0°, 10° and 20°). The tests were performed using a custom-made device consisting of the following: a motor that can record torque values of 0.1 s; interchangeable stainless-steel canals with different curvature (0°, 10° and 20°) that allow the instrument’s angulated insertion and keep it flexed during testing procedures; and a vise used to secure the instrument at 3 mm from the tip. Torque limit was set to 5.5 Ncm, and each instrument was rotated at 500 rpm until fracture occurred. Torque to fracture (TtF) was registered by the endodontic motor, and the fragment length (FL) was measured with a digital caliper. Fractographic analysis was performed using a scanning electron microscopy (SEM) evaluation to confirm the cause of failure. TtF values and fragment length (FL) values were statistically analyzed using one-way analysis of variance (ANOVA) test and the Bonferroni correction for multiple comparisons across the groups with significance set to a 95% confidence level. Regarding the F-One Blue instruments, the results showed a higher TtF for group A3 (20°) than for group A1 (0°) and group A2 (10°), with a statistically significant difference between group A3 and the other two groups (p < 0.05), whereas no statistically significant difference was found between group A1 and group A2 (p > 0.05). Regarding the HeroShaper instrument, the results showed the highest TtF for group B3, with a statistically significant difference between the three subgroups B1, B2 and B3 (p < 0.05). The results showed that the torsional resistance increases as the angle of instrument access increases with a varying intensity, according to the crystallographic phase of the instrument selected.
A Study on the Impact of Linguistic Persuasive Styles on the Sales Volume of Live Streaming Products in Social E-Commerce Environment
Authors: Luo Hanyang , Cheng Sijia , Zhou Wanhua , Yu Sumin , Lin Xudong
Published: July 2021

Live-stream shopping is developing rapidly, but the sales levels of live streaming products vary by different hosts. How to increase the sales volume of live streaming products has become a problem. Consumers’ purchase behavior in live streaming is determined by some subjective factors, and the persuasiveness of linguistic style affects this subjective judgment to a certain extent. Therefore, the persuasiveness of the hosts’ linguistic style will lead to changes in consumers’ purchase intentions, which will affect the sales volume of products sold in the live streaming. Based on Hovland’s persuasion model, Aristotle’s rhetoric skills, text analysis, Latent Dirichlet Allocation (LDA) topic extraction model and grounded theory, this study divides the host’s linguistic persuasive style in the social e-commerce environment into five types: appealing to personality, appealing to logic, appealing to emotion, appealing to reward, and appealing to exaggeration. Combined with the sales volume of the product, we establish a regression model, and obtain the influence results of the host’s various linguistic persuasive styles on the sales of live streaming products. The results show that: the linguistic persuasive style of appealing to personality has the greatest positive impact on the sales volume of live broadcast products, but the linguistic style of appealing to logic has a negative impact. Interestingly, the same linguistic style has different effects for different types of products: the linguistic style of appealing to exaggeration has a negative effect on the sales volume of apparel products, but it has a positive influence on the sales volume of digital electrical products. Therefore, different linguistic styles should be used for different product types.
Improved Metallurgical Effect of Tundish through a Novel Induction Heating Channel for Multistrand Casting
Authors: Tang Haiyan , Wang Kaimin , Li Xiaosong , Liu Jinwen , Zhang Jiaquan
Published: July 2021

Tundish with channel-type induction heating is one of new technologies adopted widely in China by the steel industry in the recent years, which can supply a constant liquid steel temperature control for the sequenced continuous casting process. For a five-strand tundish with induction heating in service, a kind of novel bifurcated split channel has been designed to solve the poor consistency of temperature and fluid flow for each strand that occurs with the conventional straight channel-type. The temperature distribution and fluid flow behaviors under the two structure modes were compared numerically by an electromagnetic-heat-flow multi-physics field coupling model. The results show that the maximum temperature difference between each strand outlet of the tundish can drop to less than 4 °C upon using the bifurcated channel, as compared to 10 °C under the original straight channel mode. According to the simulated results, case FK-A0 has been chosen as the optimized structure for industrial application. It has been verified through temperature measurements during the casting operation that the novel bifurcated split channel can improve the consistency of steel temperature for every strand of the tundish. The average temperature difference between the edge strand and the middle strand is 4.25 °C lower than the original straight channel, resulting in an upgraded metallurgical effect for the induction heated tundish.
Evaluation of Effectiveness of a Toothpaste Containing Tea Tree Oil and Ethanolic Extract of Propolis on the Improvement of Oral Health in Patients Using Removable Partial Dentures
Authors: Wiatrak Karolina , Morawiec Tadeusz , Rój Rafał , Kownacki Patryk , Nitecka-Buchta Aleksandra , Niedzielski Damian , Wychowański Piotr , Machorowska-Pieniążek Agnieszka , Cholewka Armand , Baldi Domenico , Mertas Anna
Published: July 2021

The aim of this study was to evaluate the effect of toothpaste containing natural tea tree essential oil (TTO) and ethanolic extract of propolis (EEP), on microflora and selected indicators of oral health in patients using removable acrylic partial dentures. Fifty patients with varying conditions of hygiene were divided into two groups. The study group received the toothpaste with TTO and EEP, while the control group received the same toothpaste but without TTO and EEP. At the first visit, oral hygiene and hygiene of the prostheses were carried out. Control visits took place 7 and 28 days later and compared to baseline. Indexes like API (Approximal Plaque Index), mSBI (modified Sulcus Bleeding Index), OHI-s (simplified Oral Hygiene Index), and DPI (Denture Plaque Index) were assessed in three subsequent stages, and swabs were collected from floor of the mouth area to assess the microbiota. After 7 and 28 days of using the toothpaste with TTO and EEP, a statistically significant decrease of the examined indicator values were observed in the study group as compared to the values upon the initial visit. The number of isolated strains of microorganisms in the study group was decreased or maintained at the same level, whereas in the control group an increase in the number of isolated strains was observed. The observed stabilization of oral microbiota in patients from the study group confirms the beneficial activity of toothpaste containing EEP and TTO compared to the control group.
Gold(III) to Ruthenium(III) Metal Exchange in Dithiocarbamato Complexes Tunes Their Biological Mode of Action for Cytotoxicity in Cancer Cells
Authors: Dalla Pozza Maria , Orvain Christophe , Brustolin Leonardo , Pettenuzzo Nicolò , Nardon Chiara , Gaiddon Christian , Fregona Dolores
Published: July 2021

Malignant tumors have affected the human being since the pharaoh period, but in the last century the incidence of this disease has increased due to a large number of risk factors, including deleterious lifestyle habits (i.e., smoking) and the higher longevity. Many efforts have been spent in the last decades on achieving an early stage diagnosis of cancer, and more effective cures, leading to a decline in age-standardized cancer mortality rates. In the last years, our research groups have developed new metal-based complexes, with the aim to obtain a better selectivity for cancer cells and less side effects than the clinically established reference drug cisplatin. This work is focused on four novel Au(III) and Ru(III) complexes that share the piperidine dithiocarbamato (pipe-DTC) as the ligand, in a different molar ratio. The compounds [AuCl2(pipeDTC)], [Au(pipeDTC)2]Cl, [Ru(pipeDTC)3] and β-[Ru2(pipeDTC)5] have been synthesized and fully characterized by several chemical analyses. We have then investigated their biological properties in two different cell lines, namely, AGS (gastric adenocarcinoma) and HCT116 (colon carcinomas), showing significant differences among the four compounds. First, the two gold-based compounds and β-[Ru2(pipeDTC)5] display IC50 in the µM range, significantly lower than cisplatin. Second, we showed that [AuCl2(pipeDTC)] and β-[Ru2(pipeDTC)5]Cl drive different molecular mechanisms. The first was able to induce the protein level of the DNA damage response factor p53 and the autophagy protein p62, in contrast to the second that induced the ATF4 protein level, but repressed p62 expression. This study highlights that the biological activity of different complexes bringing the same organic ligand depends on the electronic and structural properties of the metal, which are able to fine tune the biological properties, giving us precious information that can help to design more selective anticancer drugs.