bluuebunny/crossref_metadata_2025 huggingface dataset:
JURIDICAL REVIEW OF LAW ENFORCEMENT OF THE MEDICAL CODE OF ETHICSQAGAINST THE DOCTORWHO COMMITS MALPRATIC ACTS MEDICAL
Authors:   Faculty of Law, Lampung University, Bandar Lampung. Indonesia., a Rohadi , Triono Agus ,   Faculty of Law, Lampung University, Bandar Lampung. Indonesia., Soerjatisnanta Hieronymus ,   Faculty of Law, Lampung University, Bandar Lampung. Indonesia.
Published: July 2024

Formulation in this research is: (1) Indonesian Medical Code of Ethics? (2)Judges Considerations in Deciding Case Tagainst Doctors Who Commit Medical Malpracticebased on Decision Number1441/Pid.Sus/2019 /PN.Mks?. The method used is qualitative descriptive with data sources obtained from laws, books, journals and related articles. The results of this research are: In relation to violations of the code of ethics, in health law there are several ethical theories that can be used as a basis for consideration in making a decision to violate the code of ethics for the medical profession. There are three types of ethical theories that are widely known in the health aspect: Classical Ethical Theory, value ethical theory, Contemporary Ethical Theory. Decision 1441/Pid.Sus/2019/PN. Max. regarding malpractice, the perpetrator was acquitted by the judge, the perpetrator was charged with Article 79 letter c in conjunction with Article 51 letter a of Law Number 29 of 2004 concerning Medical Practice and Article 360 â€‹â€‹paragraph (1) of the Criminal Code, because it was based on the chronology of events, documentary evidence, witness statements and the defendants statement. in this case it has fulfilled the elements contained in the statutory regulations.
FINANCIAL ACCOUNTABILITY AND PERFORMANCE OF LOCAL GOVERNMENT A CASE OF GATSIBO DISTRICT
Authors:   MBA Student, School of Business Management and Economics, Mount Kenya University, Rwanda., Lea Mukeshimana , Nkechi Irechukwu Eugenia ,   Senior Lecturer, School of Business Management and Economics, Mount Kigali University, Rwanda.
Published: July 2024

Financial accountability has been one of the most prevalent issues for worldwide for a long time. The objectives of this study sought to establish the extent to which financial accountability influencelocal government performance. The specific objectives included to examine the effect of budgetary control system on the performance of Gatsibo District to examine the effect of public expenditure tracking survey on the performance of Gatsibo District and to determine the relationship between adequate internal control system on the performance of Gatsibo District. This study has couple of benefitsto the researcher herself, students and local government stakeholders by anticipating some modalities that could eventually bridge the challenges facing policy implementers in the enhancement of practice of financial accountability. The target population and sample size were 85 Gatsibo District staff. Correlational research designwas used and quantitative approaches to data collection and analysis were employed. Data analysis was done using Statistical Package for Social Scientist (SPSS).The Pearson correlation analysis reported that budgetary control system (r=0.666, p=0.000), public expenditure tracking survey (r=0.733, p=0.000) and internal control systems (r=0.748, p=0.000) were all positive and statistically significant relationship with performance of local governments in Rwanda since their p-values were less than 5%. The regression analysis showed budgetary control system (Î²1=0.219, p=0.001), public expenditure tracking survey (Î²2=0.166, p=0.003) and internal control systems (Î²3=0.307, p=0.000) were positive and statistically significant. This is because the p-value was less than 5%.Hence, the researcher recommend that public servants should embrace the financial accountability practices to improve service delivery to the community as well as improve their overall performance.
TO COMPARE THE SHEAR BOND STRENGTH OF RESIN MODIFIED GLASS IONOMER CEMENT TO COMPOSITE RESIN USING FOUR DIFFERENT ADHESIVE SYSTEMS: AN IN VITRO STUDY
Authors:   Post Graduate Student, Department of Conservative Dentistry and Endodontics, Kanti Devi Dental College and Hospital, Uttar Pradesh, India., Wangziom Mosobi Nima , Kumar Nagpal Ajay ,   Head of the Department, Department of Conservative Dentistry and Endodontics, Kanti Devi Dental College and Hospital, Uttar Pradesh, India., Singh Snehil ,   Post Graduate Student, Department of Conservative Dentistry and Endodontics, Kanti Devi Dental College and Hospital, Uttar Pradesh, India., Kumar Aditya ,   Post Graduate Student, Department of Conservative Dentistry and Endodontics, Kanti Devi Dental College and Hospital, Uttar Pradesh, India.
Published: July 2024

Aim: To evaluate and compare shear bond strength of resin modified glass ionomer cement to composite resin using different adhesive systems. Materials and Methods: 60 acrylic blocks were prepared by drilling holes to retain resin modified glass ionomer cement (GC Gold Label 2 LC Light Cured Universal Restorative-GIC). Samples were then divided into five groups (n=12) based on the generation of bonding agent used. Group I- Fifth Generation Bonding agent â€“ 3M ESPE Adper single bond 2 adhesive, Group II- Sixth Generation Bonding Agent â€“ Shofu FL Bond II Primer Self Etching Agent, Group III- Seventh Generation Bonding Agent â€“ GC Solare Universal, Group IV- Eighth Generation Bonding Agent â€“ IvoclarTetric N-Bond Universal and Group V- Control group. All the 60 specimens were filled with composite resin - Nano-Hybrid Composite (IvoclarVivadentTetric N-Ceram) over resin-modified glass ionomer cement and light cured. Shear bond strength was determined using the Universal testing Machine and directing the shearing force on the composite andresin modified glass ionomer cement interface. Amount of force required for bond failure was recorded in Newton. The data was analysed using one-way ANOVA and Post hoc Tukey test for statistical analysis. Result: Group IV showed higher bond strength followed by Group III, Group II, Group I & Group V. Conclusion: Bond strength of composite to resin modified glass ionomer cement was significantly higher for eighth generation bonding agent when compared to others.
ACADEMIC PERFORMANCE AND PARENTAL INVOLVEMENT OF INDIGENOUSSECONDARY STAGE STUDENTSIN RI-BHOI DISTRICT OF MEGHALAYA
Authors:   Assistant Professor, Department of Education, Mizoram University, Aizawl., Humtsoe Agnes , Lapang Felina ,   Postgraduate Teacher, Mount Zion Academy School, Byrnihat, Meghalaya.
Published: July 2024

Parental participation is acknowledged as a significant aspect influencing students academic achievement. This research is an effort to ascertain the influence of parental involvement on the academic performance of Indigenous secondary stage students in Ri-Bhoi district of Meghalaya. A descriptive survey method was employed, involving 340 secondary stage students. Data was collected using the Parental Involvement Scale developed by Vijaya Laxmi Chaunhan and Gunjan Ganotra Arora (2022). The findings revealed an average level of academic performance among secondary stage students, with varying levels of parental involvement. Significant differences in academic performance were observed between males and females, urban and rural students, and those attending government and private schools. However, no significant difference in parental involvement is seen among secondary school students based on gender and school type, though a significant difference is noted based on location. Additionally, no significant correlation between the academic performance of secondary stage students and parental involvement is noticed concerning this group of participants.These findings highlight the need for a multifaceted approach to improve educational outcomes, addressing disparities in academic performance, enhancing parental involvement, and providing targeted support to students based on their unique needs and circumstances.
STUDY OF THE PROPERTIES OF MORTAR INCORPORATED FROM MELTED PLASTIC BAGS
Authors:   Laboratoire Chimie Organique et Sciences de lEnvironnement (LaCOSE), Faculte des Sciences et Techniques (FaST), Universite de Kara, BP 404 Kara-TOGO., Jean-Marcel AMEWOUAME Komi ,   Laboratoire de Recherche en Sciences de lIngenieur, Ecole Polytechnique de Lome (EPL), Universite de Lome, BP 1515, Lome-TOGO., N. SEGBEAYA Kwamivi ,   Laboratoire Chimie Organique et Sciences de lEnvironnement (LaCOSE), Faculte des Sciences et Techniques (FaST), Universite de Kara, BP 404 Kara-TOGO., Agbeko KOUTO Yaovi ,   Laboratoire de Recherche en Sciences de lIngenieur, Ecole Polytechnique de Lome (EPL), Universite de Lome, BP 1515, Lome-TOGO., M. X. Dany AYITE Yawovi ,   Laboratoire de Recherche en Sciences de lIngenieur, Ecole Polytechnique de Lome (EPL), Universite de Lome, BP 1515, Lome-TOGO.
Published: July 2024

The aim of this research is to study the physical-mechanical behaviour and durability of mortars containing melted plastic bags. To this end, 4cmx4cmx16cm test specimens of mortar containing cement or not and melted plastic bags at a mass ratio ranging from 10 to 25% of the mixture were produced. Compressive strength, flexural strength and acid durability were measured. The results show that the quantity of plastics in the mortars is inversely proportional to water absorption. Similarly, cementless mortars containing 25% plastic bags (MWC25) and cement mortars containing 25% plastic bags (CM25) gave maximum compressive strengths of 9.45MPa and 10.45MPa respectively. The durability test in a 5% sulphuric acid solution showed that CM25 and MWC20 lost 50% of their mass after 28 days.
Restitución de tierras: desafíos del proceso de retorno a los predios restituidos en el departamento del Cauca
Authors: Muñoz Galindez Karol Yaqueline , Chara Ordóñez William
Published: July 2024

Este artículo analiza las dificultades que experimenta la población reparada para retornar a los predios restituidos en el departamento del Cauca. Se adopta un diseño metodológico de corte mixto para analizar datos sobre conflicto y para determinar las dificultades y retos del retorno. En el Cauca las víctimas presentan múltiples desafíos para retornar, entre ellas las condiciones de seguridad, la presencia de actores armados, la debilidad institucional y las afectaciones a la salud mental, por lo tanto, mientras la ruralidad no cuente con condiciones de seguridad y garantía de derechos el retorno será una tarea compleja para el Estado.
Para nosotros la vida cambió radicalmente. La COVID-19 y su impacto en las dinámicas familiares
Authors: Hernández Quirama Andrea , Rojas Betancur Hector Mauricio , Rivero Rubio Carolina
Published: July 2024

La pandemia de COVID-19 constituyó un cambio radical en la vida de las personas. Con el propósito de identificar las implicaciones en las dimensiones personales, familiares y sociales se realizó la investigación con enfoque cualitativo de carácter fenomenológico. Se destaca la alteración en las dinámicas familiares para implementar medidas de cuidado en la convivencia con pacientes con COVID-19, que implicaron mayores desafíos en los casos de familias con bajos recursos económicos. Se resalta el impacto en la salud física y mental de las personas que la han padecido, y un sistema de salud que requiere fortalecerse.
Monitoreo de temperatura en el aula de clase basada en Arduino
Authors: Díaz Pinzón Jorge Enrique , Rodríguez González Jorge
Published: July 2024

En la Institución Educativa General Santander, ubicada en el municipio de Soacha, Cundinamarca, se diseñó e implementó una estación meteorológica portátil con sensor de temperatura para el aula de clase. El sistema, programado con Arduino, permitió a los usuarios obtener información meteorológica en tiempo real. Los datos recopilados revelaron que la temperatura en las aulas oscila entre 24°C y 29°C. La investigación, además de resumir las condiciones ambientales actuales y los problemas existentes en las aulas, evidenció cómo la integración de sensores al sistema permite el monitoreo y cómputo del nivel de temperatura. Al crear un ambiente de aprendizaje con una temperatura adecuada, se puede fomentar el éxito académico y el desarrollo personal de los estudiantes.
Honey and propolis reduce the antibacterial resistance of staphylococci
Authors: IOANA LAZĂR CRISTINA , GHEORGHIȚA DUCA , DANA ȘANDRU CARMEN , DIANA OLAH , EMOKE PALL , CONSTANTIN CERBU , OVIDIU GIURGIU , ADRIAN POTARNICHE , AUREL VASIU , MARINA SPÎNU
Published: July 2024

Antimicrobial resistance (AMR) is a significant public health concern of the 21st century, contributing to an increasing number of deaths in both human and veterinary medicine. Multi-antibiotic-resistant bacteria, such as S. aureus, Escherichia coli, Pseudomonas aeruginosa, Enterococcus faecium, Streptococcus pneumoniae, and Klebsiella pneumoniae, pose substantial challenges. This research investigated changes in antibiotic susceptibility of Staphylococcus spp. Isolates from extensively farmed pigs (n = 421) when exposed to different types of honey (multi-floral, n = 1, and rapeseed, n = 2) or different commercial propolis concentrations (20% and 30% in 70% ethanol). Thirty species of staphylococci were identified using classical bacteriology techniques. Initial antimicrobial resistance/susceptibility was tested against colistin, erythromycin, sulfamethoxazole/ trimethoprim, penicillin, florfenicol, vancomycin, tetracycline, imipenem, marbofloxacin, cefoxitin, clindamycin, and methicillin using the Kirby Bauer disk-diffusion method. Following exposure to bee products, susceptibility to antibiotics was reassessed using the same protocol. The MAR index and percentage of strains resistant to each antibiotic were calculated. Results showed a relatively low MAR index in 90% of the strains, with 26.7% showing no resistance, 20% with a MAR index of 0.08, and 43.3% with a MAR index of 0.16. However, 10% of the strains exhibited mild resistance or high resistance (MAR index of 0.25, 0.33, and 0.58), posing risks to animals, caretakers, and the environment. Following exposure to bee products, changes in susceptibility to different antibiotics were observed. The highest number of strains initially classified as resistant and reclassified as sensitive were found for penicillin and tetracycline, followed by sulfamethoxazole, methicillin, and cefoxitin. Changes were more pronounced in strains classified as moderately resistant, with significant differences (p < 0.05-p < 0.001) observed between antibiotics. The findings suggested that honey and propolis could reduce antimicrobial resistance in staphylococci isolated from healthy pigs, thus serving as natural alternatives to antimicrobial treatment for staphylococcal infections.
Computer-Aided Drug Design Studies in Association with in vitro Antileishmanial Tests for New Chalcones
Authors: R. da Silva Gleice , S. Santos Francisnaira , F. Leite Fernando , A. H. Acevedo Chonny , F. de Sousa Natália , B. Grimaldi Gabriela , B. P. Soares Milena , T. Guimarães Elisalva , T. Scotti Marcus , Cezar Rodrigues Luis , J. B. Mendonça Júnior Francisco , H. Campana Eloísa , M. Barbosa Filho José , I. F. Magalhães Hemerson , Q. S. Guerra Felipe
Published: July 2024

In silico and in vitro tests can reveal promising anti-leishmania activity for natural products and their derivatives. The aim of this study was to investigate in silico the pharmacological activities of potential new chalcones and their leishmanicidal potential in vitro. The in silico study was carried out using the PASS, MolPredictX and Molegro Virtual Docker 6.0 programs. Antiparasitic activity was assessed in axenic promastigote and amastigote forms of Leishmania braziliensis. The cytotoxicity tests used the J77G8 cell line. The chalcones exhibited 50% cytotoxic concentration values (CC50) values > 50 μM. Chalcone 4 (named FERAI) presented the best activity with concentration for 50% of promastigotes and intracellular parasites forms (EC50) of 9.75 ± 1.7 and 10.13 ± 1.7 μM for promastigote and amastigote, respectively. Reactive oxygen species (ROS) testing presented increased ROS levels in the parasite at the FERAI concentrations of 10 μM (56.33%), 20 μM (61.76%) and 30 μM (67.13%). Molecular docking revealed interactions (binding energy) between FERAI and the enzymes UDP-glycosyl pyrophosphorylase (-56.8384), dihydroorotate-dehydrogenase (-132.276) and trypanothione-reductase (-151.281). Our results demonstrated the anti-leishmanial activity of chalcones, especially FERAI, with a noted raising of ROS levels in the parasite. Molecular docking revealed dihydroorotate dehydrogenase and trypanothione reductase as potential pharmacological targets for FERAI.
Sustainable Recycling of Spent Li-Ion Batteries and Iron Ore Tailings for Cobalt Ferrite Synthesis and Its Dual Applications as a Photocatalyst in Solar Photo-Fenton Process and an Electrochemical Sensor
Authors: Almeida Jenifer , Moura Mayra , Magnago Luma , Rocha Ana , Coelho Edson , Ferreira Sandra , Lelis Maria de Fátima , de Freitas Marcos
Published: July 2024

This study presents a solution to solid waste problems, focusing on spent lithium-ion batteries (LiBs) and iron ore tailings (IOT) from the Mariana environmental accident in Brazil. The approach involves the production CoFe2O4 from LiBs and IOT, which serves as a catalyst for solar photo-Fenton reactions for methylene blue (MB) decolorization and as an electrochemical sensor for ascorbic acid (AA) detection. Chemical analysis showed recycling potential, with 45.22 ± 0.22% m m−1 Co from LiBs and 14.9 ± 1.5% m m−1 Fe from IOT, determined by inductively coupled plasma atomic emission spectroscopy (ICP OES) and flame atomic absorption spectrometry (FAAS). The sol-gel synthesized CoFe2O4 exhibited a crystallite size of 51.9 ± 1.3 nm and agglomerated crystal clusters. Recycled-CoFe2O4 exhibited a 98.1% MB decolorization efficiency in 60 min under solar irradiation and remained above 92.3% in all 7 reuse cycles. The electrochemical sensor exhibited a coefficient of determination of 0.9987, a sensitivity of 3.352 ± 0.0428 μA mol L−1, and a limit of detection of 0.5511 µM in the concentration range of 1.96 to 23.08 mmol L−1 for AA detection. This study demonstrates the potential of recycled-CoFe2O4 in an environmentally friendly dye removal and as an electrochemical sensor, offering sustainable waste management and resource utilization with solar energy.
Impacts of climate change and variability on drought characteristics and challenges on sorghum productivity in Babile District, Eastern Ethiopia
Authors: Tolossa Abdisa Alemu , Dadi Diriba Korecha , Mirkena Lemma Wogi , Erena Zelalem Bekeko , Liben Feyera Merga
Published: July 2024

Examining the characteristics of drought indices in the context of climate variability and change, particularly in semi-arid water-stressed regions, requires adaptation. Observed climate data of the Babile station from 1980 to 2009 were used as a baseline for climate projection. Future climate projection was established under two Representative Concentration Pathway (RCP4.5 and RCP8.5) climate scenarios for the 21st century. Two drought indices, namely standard precipitation index and standard evapotranspiration index (SPI and SPEI) were employed based on temperature and rainfall to characterize droughts. Our study revealed that drought severity and intensity are more likely to increase under RCP4.5 climate forcing in the middle of the 21st century. The average drought severity (S) was 1.1, 1.53, 1.55, and 1.8 in SPEI 3-month time scale; 1.51, 2.1, 2.38, and 2.29 in SPEI 4-month time scale; and 2.15, 2.77, 3.44, and 2.91 in SPEI 6-month time scale, whereas, the drought severity (S) was 1.33, 1.37, and 1.79 in SPEI 3-month time scale; 1.79, 2.05, and 2.19 in SPEI 4-month time scale; and 2.47, 3.19, and 2.69 in SPEI 6-month time scale in observed, near, mid and end of the 21st century under RCP4.5 and 8.5 scenarios, respectively. Increase in drought frequency and severity occurrences under RCP4.5 scenario would have a negative impact on sorghum crop productivity. We recommended further study on practical soil water conservation to drought management in the study area.
Enhanced photocatalytic degradation of methylene blue dye using CuO nanoparticles from the fruit extracts of Diplocyclos palmatus (L) C. Jeffrey for wastewater remediation
Authors: G. T. Parethe , P. Rajesh , V. Velmani , M. Balaji , S. Kavica
Published: July 2024

The degradation of synthetic organic dyes through photocatalysis requires structured nanoparticles (NPs). Copper oxide (CuO) NPs were used as the newest developed catalyst for the organic dye degradation under the irradiation of sunlight: The metal oxide NPs were synthesized using the fruit extract of Diplocyclos palmatus (L) C. Jeffrey. UV–visible light spectra showed an absorption band for CuO NPs at 277 nm. X-ray diffraction confirmed the monoclinic phase of CuO NPs. Scanning electron microscopy confirmed rod-shaped stacked particles. Energy-dispersive X-ray spectra indicating the presence of Cu in oxide form. For the degradation of methylene blue dye (MB), CuO NPs were used as photocatalyst for dye degradation under sunlight irradiation. This study confirmed the effects, such as irradiation time, concentration, pH, and catalyst dosage. The CuO NPs showed high photocatalytic degradation, degrading 90% of the dye in 120 min. The increased degradation of dye was observed on exposure to longer irradiation time. The increased concentration of dye resulted in a decreased rate of photodegradation. 95% degradation achieved at pH 9 showing that the pH medium also enhances the degradation. A higher dye degradation percentage was achieved by increasing the higher catalyst dosage of 0.013 g degraded 93% of dye. Thus in the treatment of wastewater containing pollutants, the synthesized CuO NPs acted as an efficient photocatalyst.
Water quality analysis, treatment, and economic feasibility of water services of the Neora River in the fringe area of Neora-Valley National Park, India
Authors: Mukherjee Sahana , Saha Jayeeta , Sharma Neha , Das Sovik , Chaturvedi Shiva Shankar
Published: July 2024

Surface water assessment is essential for an accurate water management plan. The present investigation was focused on quality analysis, treatment, and economic feasibility of the River Neora, a raw water source in the fringe area of the Neora-Valley National Park, India. Pearson's correlations showed a positive correlation (0.629) between temperature and total solids (TS), whereas a negative correlation (−0.23) for dissolved oxygen with other parameters. In ANOVA, F-value (>1) was obtained for all parameters except BOD5. The water quality index (WQI) was determined to find out whether the river water meets the drinking water requirements for local inhabitants in the lower fringe. A high coliform count (approximately 4.5/100 mL) downstream further warranted the design of an advanced treatment, the electrochemical oxidation batch reactor. To maintain the water quality grade, the estimation of water benefits was mandatory. The water consumption for domestic and non-domestic purposes was calculated at 5,314,400 and 1,470,000,000 L/yr, respectively. Obtainability and no tax coverage might have led to the overexploitation of water, which paved the way for monetary evaluation (US$695.29). This study provided an overview of the potential of River Neora, which can be restored in the long run by adopting the water development policies by the government.
Alkalinity control in sludge propels the conversion of concrete slurry waste into micro- and nano-sized biogenic CaCO3
Authors: Zhao Jinbo , Feng Jiacheng , Du Yifan , Yan Zhiyang , Li Xiaoguang , Qin Jinyi , Su Ming , Yang Min
Published: July 2024

The utilization of Bacillus sp. for the production of bio-CaCO3 in concrete crack repair and strength enhancement has attracted considerable attention. However, microbial-induced calcium carbonate precipitation (MICP) has yet to be explored as a precedent with activated sludge. Here calcium sourced from concrete slurry waste (CSW) and carbon from sludge microbial β-oxidation under alkaline were used to generate micro/nano CaCO3. The results indicate that the main crystalline form of the generated precipitated particles is calcite, with a particle size ranging from 0.7 to 10 μm. Minimal heavy metals were found in the supernatant following settling. And at the optimum pH of 8.5–9, carbon capture reached 743 mg L−1, and CaCO3 production reached 1,191 mg L−1, and dominant phylum were Proteobacteria and Bacteroidota, with Thauera being a prevalent genus adept in β-oxidation. Mass balance analysis showed that alkali promotes microbial β-oxidation of organisms to produce CO2 and facilitate storage. Thus, the alkaline regulation of metabolism between microbe and CSW provides a novel way of sludge to initiate MICP.
A história da substituição da metafísica, contada pela Crítica da Razão Pura
Authors: Vollet Lucas Ribeiro
Published: July 2024

A transição do modelo metafísico de produção de conhecimento sobre a necessidade, para o modelo científico moderno, exigia uma investigação filosófica dos seus fundamentos, que Kant forneceu nas últimas décadas do século XVIII. Séculos depois, a análise dessa fina operação ainda desvenda perspectivas de nossa auto-compreensão como seres capazes de representar a solubilidade dos problemas sobre a verdade em uma unidade cognoscível. Muito antes de abrir o debate sobre as condições cognitivas técnicas e formais (na ciência cognitiva e na semântica moderna), Kant mostrou a capacidade reflexiva do humano para representar essas condições transcendentalmente como um problema que não é indecidível para si mesmo. Pela clareza sobre o problema originário e pelo alcance de sua leitura das consequências desse problema, Kant ainda é o marco zero de uma problematização do humano como o ser cuja presença no mundo estebelece os parâmetros para o possível e o necessário – uma discussão que pervade as ciências humanas e naturais, e que será de utilidade fundamental para o debate que tende a se intensificar nos próximos anos sobre a inteligência artificial.
Podemos decolonializar a herança kantiana?
Authors: Dias Maria Clara
Published: July 2024

O artigo analisa a compreensão de moralidade fornecida por Kant em sua Fundamentação da Metafísica dos Costumes, de forma a examinar sua possível contribuição para uma filosofia crítica do saber de matriz colonial. Para tal, distingue a tentativa kantiana de resgatar a pretensão de validade universal de nossos enunciados morais e os conteúdos universais fixados pela tradição filosófica de matriz colonial, da qual a filosofia kantiana é um dos principais pilares. Em seguida, propõe uma reconstrução do Imperativo Categórico e uma redefinição dos indivíduos aos quais devemos respeito ou consideração moral, capaz de ampliar o escopo da moralidade a todos os seres humanos, animais não humanos e outros sistemas funcionais complexos, tais como o meio-ambiente e obras de arte. Desta forma, o artigo procurar suprimir hierarquias que até hoje sustentam a subordinação de diversos indivíduos ou grupos a seres supostamente racionais e livres, cujas características foram naturalizadas e elevadas ao topo de uma hierarquia de saber e poder.
Kant e o sustento [Versorgung] dos pobres:
Authors: Dutra Delamar Volpato
Published: July 2024

O presente texto faz dois movimentos interpretativos a respeito do sustento [Versorgung] dos pobres na RL.[1] O primeiro movimento visa a responder a seguinte questão: por que o Estado tem que sustentar os pobres? Para responder a esta questão, busca-se indicar, no texto de Kant, um espelhamento do Leviatã de Hobbes. Desse modo, pretende-se avançar a hipótese de que a posição kantiana reflete aspectos importantes da perspectiva hobbesiana, no sentido de que certos traços, os quais comporiam o que se poderia nominar como determinações metafísicas do direito, seriam explicáveis pela posição naturalizada de Hobbes, mormente no referente a certos caracteres que se poderiam remeter à natureza humana. Esse movimento permitirá uma leitura do texto em consonância com a interpretação dita instrumental ou prudencial, não obstante, agora pensada de modo peculiar. O segundo movimento visa a responder à seguinte questão: por que os pobres são excluídos por Kant da cidadania ativa? Para responder a esta questão, usa-se da distinção entre liberdade, igualdade e independência, feita no texto Contra Hobbes. Intenta-se, com isso, tornar coerentes os posicionamentos de Kant sobre a desigualdade de propriedade e sobre a distinção entre cidadania ativa e cidadania passiva. Tal estratégia determinará uma interpretação da situação dos pobres em termos de liberdade e de igualdade, mas não de independência. A maior vantagem desse posicionamento consiste em não confundir o princípio da liberdade com o princípio da independência, algo que alguns comentadores fizeram, como aqueles da Escola de Toronto.
 
[1] As referências a Kant, incluso no que diz respeito às abreviaturas, seguem a uniformização proposta pela Kant-Studien Redaktion, disponíveis em [http://www.kant.uni-mainz.de/ks/abhandlungen.html]. As citações literais são feitas a partir das traduções para o vernáculo das referidas obras
PERSPECTIVAS SOBRE O COSMOPOLITISMO JURÍDICO À LUZ DO PROJETO KANTIANO DE PAZ PERPÉTUA
Authors: PROVINCIATTO LUÍS GABRIEL , Caran Seibel Reganati Rafael
Published: July 2024

Este artigo busca revisitar o ideal de paz perpétua proposto por Immanuel Kant (1724-1804) à luz das teses apresentadas por Jürgen Habermas (1929) em A ideia kantiana de paz perpétua – à distância histórica de 200 anos (1995). Explora-se a transição no pensamento kantiano de um cosmopolitismo forte para uma abordagem mais branda, centrada no direito internacional. Analisam-se as propostas de Habermas para reformular a Organização das Nações Unidas (ONU), destacando a necessidade de normas vinculantes e uma constituição global. Essa pesquisa interdisciplinar entre filosofia e direito destaca também as dificuldades contemporâneas na manutenção da soberania dos Estados frente à globalização. O diálogo entre os filósofos Kant e Habermas e o jurista Herbert Hart (1907-1992) revela perspectivas divergentes sobre a construção de um direito internacional eficaz. Em conclusão, ressalta-se a urgência de colaboração entre filósofos e juristas na busca por alternativas que promovam a paz e resguardem a soberania estatal, destacando também a relevância contínua do referencial teórico kantiano para enfrentar desafios contemporâneos na busca por um projeto de paz perpétua.
O Dever não esta morto
Authors: Nahra Cinara
Published: July 2024

Resumo: O objetivo deste ensaio é mostrar que, apesar de um possível descompasso entre a visão de moralidade das “pessoas comuns” na sociedade ocidental do século XXI e a concepção kantiana do dever, a idéia de Dever Kantiana continua viva e o respeito aos quatro deveres clássicos Kantianos, enunciados na Fundamentação da Metafísica dos Costumes, uma vez revistos e atualizados, são imprescindíveis para o bom funcionamento da sociedade contemporânea, para a continuidade da civilização humana e mesmo para evitar a destruição da espécie humana e do nosso planeta
Palavras chaves: Dever; deveres kantianos; moralidade; Imperativo Categórico
A aporia entre guerra e paz na filosofia política de Kant
Authors: Barbieri Durão Aylton
Published: July 2024

Guerra e paz constituem uma das aporias mais intrigantes do pensamento de Kant. A paz perpétua é uma ideia da razão com validade objetiva na filosofia moral, por isso, deve orientar as ações, porém constitui apenas uma ideia reguladora para a filosofia teórica, por conseguinte, pode ser pensada, mas não pode ser conhecida. Esta aporia se mostra tanto na história filosófica, a qual explica como o antagonismo da insociável sociabilidade se serve da guerra para alcançar o fim da paz perpétua, quanto da própria razão prática que compatibiliza o seu veto da guerra ofensiva com o direito à guerra.
O legado kantiano para as relações internacionais
Authors: Lima Francisco Jozivan Guedes
Published: July 2024

Este artigo tem como objetivo fundamental apresentar o legado de Kant para as relações internacionais a partir dos artigos preliminares de À paz perpétua (1795). A maioria dos estudos foca sua atenção nos artigos definitivos, porém esquece de analisar a relevância daquilo que antecede. O ponto hipotético desta investigação é que sem os artigos preliminares, os artigos definitivos para a paz entre os povos não têm força suficiente. De um ponto de vista metodológico, este artigo está articulado em duas partes: uma propedêutica sobre o legado da filosofia crítica objetivando reconsiderar a contribuição do autor em termos concretos para a filosofia preparando o caminho para À paz perpétua e, em seguida, uma abordagem focada nas contribuições dos artigos preliminares para a construção pacífica das relações internacionais.
Prevalence of Nosocomial Infections and the Pattern of Microbial Resistance in
a Tertiary Care Referral Hospital (Alzahra), Isfahan, Iran
Authors: Tolou-Ghamari Zahra , Pourdad Arezoo , Foroughi Zahra , Ataei Behrooz , Palizban Abbas Ali
Published: July 2024

Background:

Nowadays, the resistance to available antibiotics could be mentioned as a global threat to public health. The aim of this preliminary study was to
conduct a retrospective survey associated with the prevalence of Nosocomial Infections (NIs) and the pattern of microbial resistance in a tertiary
care referral hospital (Alzahra), Isfahan, Iran.

Methods:

The data between the years 2016 to 2022 were extracted from the official database of hospital NI records. The microbiological culture results,
represented by non-repetitive specimens, were further analyzed for pathogens and the pattern of antibiotic resistance. Then antibiotic susceptibility
testing was done using standard methods of disk diffusion or Phoenix M50. The recorded variables have been presented as mean ± standard
deviation, prevalence, and percentage. Data were analyzed using SPSS version 20.

Results:

For a duration of 5.5 years, the period prevalence of NIs was recorded as 2%, with more than 50% associated with ventilator-associated events and
urinary tract infections. Klebsiella pneumonia, Acinetobacter baumannii, and Staphylococcus were the main pathogens. Further study of specimens
from the year 2022 (n= 898) confirmed the most isolated bacteria as Klebsiella pneumonia (n = 290, 32%), Acinetobacter baumannii (n= 206,
23%), Enterococcus (faecium-fecalis n=125, 14%), Escherichia coli (n = 116, 13%), Staphylococcus aureus (n = 95, 11%), and Pseudomonas
aeruginosa (n = 66, 7%). Resistance (R%) in Isfahan versus the whole country was confirmed for Klebsiella pneumonia (third or fourth generation
of cephalosporins: R = 80.9 vs. 82%), fluoroquinolones (R = 76.6 vs. 73%), beta-lactamase inhibitors (R = 75 vs. 79%), carbapenems (R = 65.7 vs.
66%), and so on, respectively.

Conclusion:

There has been reported an increase in the proportion of isolates resistant to cephalosporins, fluoroquinolones, and others. The variety of latent
pathogens resistant to frequently administered antibiotics highlights the significance of continued and homogenous antimicrobial evidence-based
pharmacotherapy investigations in Isfahan, Iran. Further studies in this direction are recommended.
Immunotherapies: A Treasure Trove of Alzheimer's Disease
Authors: Kolay Ankit , Singh Neelam , Gupta Puneet , Shaikh Ayaz Mukarram , Goel Radha , Nagpal Dheeraj , Chitme Havagiray
Published: July 2024

Alzheimer’s disease (AD) is a progressive neurodegenerative disease that falls under
the umbrella of dementia and is characterized by the presence of enormously neurotoxic amyloid-beta (Aβ) plaques and neurofibrillary tangles (NFTs) of tau protein inside the brain. AD
remains an intractable global health challenge with limited therapeutic options. Early diagnosis,
enabled by biomarkers and neuroimaging, is pivotal for optimizing treatment outcomes. Immunotherapeutic strategies, including monoclonal antibodies, active vaccination, and passive immunization, have been developed to target hallmark AD pathology, such as amyloid-beta aggregation. Here we summarized the emerging role of immunotherapies in the early stages of AD,
shedding light on recent breakthroughs and clinical progress. Challenges, including treatment
response variability and safety concerns, are discussed alongside evolving approaches, such as
personalized immunotherapy and combinatorial treatments. This concise review underscores the
promise of immunotherapies as a transformative approach to AD intervention, offering hope for
a brighter future in the quest to combat this devastating neurodegenerative disease.
LncRNA DERCNC in Hepatocellular Carcinoma with Cirrhosis
Aggravates Tumor Proliferation by Targeting SOX9
Authors: Wang Yun-Bing , Salameen Haitham , Hu Yi-Yu , Zhou Shi-Ji , Gong Jun-Hua
Published: July 2024

Purpose:

This study aims to understand the role of cirrhosis in promoting hepatocellular carcinoma (HCC) progression by analyzing the differential expression of long noncoding
RNAs (lncRNAs) between cirrhotic hepatocellular carcinoma (CHCC) and noncirrhotic hepatocellular carcinoma (NCHCC).

Methods:

A transcriptional profile array was used to identify differentially expressed lncRNAs.
Subsequently, a specific lncRNA was selected to evaluate the clinical significance, potential
functions, regulatory targets, and pathways through both in vitro and in vivo experiments.

Results:

The study identified a lncRNA, which we termed DERCNC, an acronym for Differentially Expressed RNA between Cirrhotic and Non-Cirrhotic HCC. DERCNC was significantly
more highly expressed in CHCC than in NCHCC. Clinically, elevated levels of DERCNC expression were positively correlated with both the cirrhotic state and tumor stage and inversely
correlated with tumor differentiation. Furthermore, high expression of DERCNC was associated
with a poor prognosis for patients. Conditioned medium from the hepatic stellate cell (LX2) was
found to enhance DERCNC expression, SOX9 expression, and tumor proliferation. Overexpression of DERCNC similarly promoted tumor proliferation and increased SOX9 levels. Conversely, DERCNC silencing resulted in the opposite effects. Moreover, the pro-proliferative
function of DERCNC was reversible through the modulation of SOX9 expression. Further
mechanistic studies revealed that DERCNC upregulated SOX9 by increasing the enrichment of
H3K27ac modifications near the SOX9 promoter.

Conclusion:

In conclusion, DERCNC expression in CHCC has significant clinical implications
and can aggravate tumor proliferation by targeting SOX9. This represents a novel mechanism
by which cirrhosis promotes tumor progression.
Investigation on the Potential of Some N-phenylalkanehydrazides as Superoxide Anion Radical Scavengers and Glutathione Peroxidase Binders
with ADME Prediction: Comparison with Vitamin C
Authors: Mouada Hanane , Lanez Touhami
Published: July 2024

Objective:

An investigation on the antioxidant activity and ADME properties of some
N-phenylalkanehydrazides (NPhs) in comparison with ascorbic acid was carried out.

Materials and Methods:

The power of the compounds to scavenge the superoxide anion radical
was examined using cyclic voltammetry. Furthermore, molecular docking was used to examine
how NPhs bind to the antioxidant enzyme glutathione peroxidase (GPx). Finally, ADME properties
were predicted using the SwissADME webserver.

Results:

The results showed that the studied compounds had significantly higher EC50 values than
Vitamin C and displayed spontaneous binding with GPx with binding energy similar to ascorbic
acid. Also, substantial values emerged from the predictive analysis of drug-likeness and bioavailability
characteristics.

Discussion:

First, the EC50 of the compounds under study was determined by assessing the decrease
in the anodic current peak intensity; this demonstrated significant radical scavenging activity.
Next, the electrostatic way of binding with ROS radical and with antioxidant enzyme was
disclosed by the binding free energies; however, the oxygen and nitrogen atoms in the compounds'
structures might make many conventional hydrogen bonds with amino acids. Finally,
NPh (a) followed all the rules for drug-likeness and bioavailability estimates, making it a promising
moiety for synthesising new antioxidant chemicals.

Conclusion:

The current study is a hybrid of experimental and computational methods that complement
each other perfectly.
Internet of Healthcare Things Based Detection of EEG Epileptic Seizures:
A Smart System
Authors: Thakur Tanishk , Rana Naresh , Jain Shruti
Published: July 2024

Background:

A seizure is a sudden and uncontrolled electrical activity in the brain that
can cause a variety of symptoms, depending on the location and severity of the abnormal activity. It
can be a symptom of an underlying neurological disorder or can occur without an apparent cause.
Epilepsy is one of the most common causes of seizures. Overactive electrical discharges disrupt normal brain electrical activity and interfere with nerve cell communication.

Aim and Objective:

A comprehensive analysis of the literature revealed that several CAD system
designs have shown to be useful to radiologists in routine medical practice as second-opinion aids for
epileptic seizure detection in circumstances where a clear differentiation cannot be formed subjectively.
CAD systems are made to help radiologists by automating the examination of medical data and images, improving the efficiency and accuracy of diagnosis. These systems examine patterns in medical
imaging using machine learning approaches, which can be quite helpful in spotting small abnormalities that the human eye can miss. Moreover, the objective of this study was to design a smart
healthcare system using a combination of DWT, Hjorth, and statistical parameters for seizure detection.

Method:

In this research article, the authors proposed the framework of the Internet of Healthcare
Things (IoHT) for performing seizure detection. The authors used different pre-processing techniques
and extracted different features like Hjorth, wavelets, and statistics, which were classified using different machine-learning techniques. This novel methodology combines a number of technologies and
techniques to improve seizure detection's precision and dependability.

Results:

DWT + Hjorth + Statistical parameters with bior 1.5 as the pre-processing technique yielding
the best outcomes. 86% accuracy was obtained with kNN for k = 5, 93% accuracy was obtained with
a linear kernel for an SVM classifier, and 95.5% accuracy was obtained using a decision tree and
logistic regression. The authors also considered another dataset for validation and received 96.83%
accuracy with decision tree and logistic regression classifiers considering the bior1.5 wavelet filter
as a preprocessing technique.

Conclusion:

The IoHT framework offers a multi-modal, adaptive method of seizure detection that
enables the dynamic modification of detection parameters and the incorporation of extra sensor signals. This improves seizure detection's precision and dependability, which has important implications
for patient care and monitoring. This work shows how IoHT and machine learning can be combined
to build a reliable, real-time seizure detection system. These developments, which make it possible
for prompt interventions and individualized treatment plans, can significantly improve the quality of
care for individuals with epilepsy.
TNF-alpha Inhibitors Induced Eosinophilia: A Case Report of an Undervalued Side Effect of Such Biologicals
Authors: Diomeda Federico , Calogiuri Gianfranco , Congedo Maurizio , Filoni Angela , Sordi Emiliano , Fiore Massimo , Pietroleonardo Lucia , Piscitelli Prisco , Civino Adele
Published: July 2024

Introduction:

We present an unusual case of a 28-year-old rheumatologic male patient
who developed eosinophilia while he was on etanercept therapy previously and then on
golimumab.

Case Representation:

Although eosinophilia is rarely reported in the literature as a side-effect
of various Tumor Necrosis Factor-alpha (TNF-alpha) antagonists, it represents a riddle about
the future treatments of these patients since the persistence of therapy might lead to the onset of
dermatologic or visceral eosinophilic complications in such patients.

Conclusion:

Furthermore, the pathogenesis of eosinophilia is still unknown, and all the proposed
hypotheses do not explain the eosinophilic proliferation in certain subjects.
The Role of Local Angiotensin II/Angiotensin Type 1 Receptor in Endometriosis: A Potential Target for New Treatment Approaches
Authors: Moazen Shirin , Arjmand Mohammad-Hasan
Published: July 2024

:

Endometriosis is a chronic inflammatory disorder described by the presence of functional endometrial-like tissues at extra-uterine locations that are
related to chronic pelvic pain and infertility. Multiple molecular mechanisms, including inflammation, reactive oxygen species (ROS) generation,
fibrotic reactions, and angiogenesis, are involved in the pathogenesis of endometriosis; however, the exact cause of this disorder still remains a
matter of discussion. Recently, it has been shown that the local renin-angiotensin system (RAS) has been expressed in different tissues, like the
gynecological tract, and alterations in its expression are associated with multiple pathological conditions like endometriosis. Angiotensin II (Ang
II), as a main peptide of the RAS through angiotensin type 1 receptor (AT1R), upregulates signal transduction pathways such as nuclear factor
kappa B (NF-κB), mitogen activation protein kinase (MAPK), and transforming growth factor beta (TGF-β) to promote inflammation, oxidative
stress, and fibrogenesis. Angiotensin receptor blockers (ARBs) control high blood pressure, which is increased by excessive AT1R activity.
Recently, it has been recognized that ARBs have tissue protective effects because of their anti-inflammatory and antifibrotic effects. In this review,
we focused on the role of local Ang II/AT1R axis activity in endometriosis pathogenesis and justified the use of ARB agents as a potential
therapeutic strategy to improve endometriosis.
An Energy-Balance Clustering Routing Protocol for Intra-Body Wireless Nanosensor Networks
Authors: S Santhosh , B Vamshi Krishna , Mudarakola Lakshmi Prasad , Mukherjee Saptarshi , Yesubabu Mannava , Sharma Vikas
Published: July 2024

Aims and Background:

Numerous sensor nodes spread out across the surveillance region
form the Wireless-Sensor Network (WSN), a smart, self-organizing network. Since the lumps
can typically only be motorized by batteries, creating a WSN while maintaining an optimal energy
balance and extending the network's lifetime is the biggest issue.

Methods:

A novel network architecture that integrates nanotechnology with sensor networks is
known as a Wireless-NanoSensor-Network(WNSN). A new area of focus in research is intra-bodyiWNSNs,
which are WNSNs with promising potential applications in biomedicine, damage detection,
and intra-body health monitoring. We suggest an energy-balance-clustering-routing protocol
(EBCR) for iSN nodes that have limited energy storage, short communication range, and low computation
and processing capabilities. The protocol uses a novel hierarchical clustering approach to
lessen the communication burden on nano-nodes.

Results:

Cluster nano-nodes can use one-hop routing to send data directly to the Cluster-Head(CH)
nodes, and the CH-nodes can utilize multi-hop routing to send data to the nano control node. In addition,
selecting the next hop node to minimize energy usage while guaranteeing successful data
packet delivery involves balancing distance and channel capacity. The protocol's strengths in energy
efficiency, network-lifetime extension, and data-packet transmission success rate were highlighted
by the simulation results.

Conclusion:

It is clear that the EBCR protocol is a viable option for iWNSNs' routing system.