bluuebunny/crossref_metadata_2025 huggingface dataset:
Ability of Azadirachta indica and Ocimum gratissimum to inhibit the growth of some hospital isolates
Authors: CHIBUISI FRANCIS OGBUKA  , NGOZI O IZUCHUKWU  , OGWO ELISHA UKO  , JESSICA EZINNE EKELEME  , OGECHI JULIANA OGBODO
Published: May 2024

The study on the ability of Azadirachta indica and Ocimum gratissimum to inhibit the growth of some hospital isolates was carried out following several reports on the antimicrobial potentials of these plant leaves among locals. Some fresh leaves of Azadirachta indica and Ocimum gratissimum were processed into an aqueous extract as well as an ethanolic extract and preserved at 4oC. samples of Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli and Candida albicans which served as test microorganisms were obtained from the Federal Medial Centre Umuahia Abia State Nigeria. Antimicrobial sensitivity test of test isolates was determined using the Kirby-bauer disc diffusion method Disc diffusion method of the extracts . A 0.5 Mc farland solution of the 4 organisms were prepared and inoculated into an already prepared Mueller hinton agar plates containing the paper disc of 400mg/ml aqueous and ethanolic extracts. A control experiment was set up with 2mg/ml gentamycin disc. After 48 hours incubation, Ethanolic extract of Azadirachta indica showed the highest zones of inhibition of 7.5mm on Staphylococcus aureus, followed by ethanolic extract of Ocimum gratissimum 7.0mm on Escherichia coli. While the aqueous extracts of both Azadirachta indica and Ocimum gratissimum showed least zones of inhibition on Candida albicans. The overall were more antibacterial effective than antifungal. Therefore, the Ethanolic extract of Azadirachta indica and Ocimum gratissimum possess more antibacterial effect and less antifungal effect.
Right sided congenital diaphragmatic hernia
Authors: Najib Chiboub  , Mohammed Mimouni  , Othmane Alaoui  , Abdelhalim Mahmoudi  , Khalid Khattala  , Youssef Bouabdallah
Published: May 2024

Introduction: Congenital diaphragmatic hernia is a rare affection, has been classified as posterolateral, anterior or central. The posterolateral defect occurs on the left side (85%), although it may involve the right side (13%) or be bilateral (2%). Patients and methods: We report the evolution after surgical treatment of right diaphragmatic hernia in one case. Results: A male neonate, born via uncomplicated vaginal delivery at a gestational age of 10 days, weighed 3.8 kg at birth and initially presented with weak crying and a dusky skin tone. He required intubation and was placed on a ventilator. Subsequent imaging studies including chest radiography and CT scan revealed a right congenital diaphragmatic hernia, while ultrasound confirmed the presence of pulmonary hypertension. Following stabilization, the newborn underwent thoracotomy surgery, during which intraoperative exploration revealed the entire liver within the thoracic cavity along with intestinal loops. The liver was challenging to maneuver but was successfully relocated into the abdomen, and the intestinal loops were reduced. Repair of the diaphragmatic defect was accomplished using non-absorbable sutures. Following surgery, the neonate was transferred to the neonatal intensive care unit (NICU), where a postoperative chest radiograph on the fourth day showed expansion of the right lung. Over the subsequent two years, the patient's condition remained stable without the development of respiratory complications or worsening symptoms. Conclusion: Success in this difficult case is optimized by close cooperation between the neonatologist, anesthesiologist, and pediatric surgeon. Although the hospital stay was prolonged, the survival outcome is excellent in this high-risk case.
Systematic review: How to obtain Fibrinolytic Enzymes from Fungi
Authors: Aulia Ramadhan Supit  , Arfat Lusinanto  , Titin Ariyani  , Dwirini Retno Gunarti
Published: May 2024

Fibrinolytic complications such as stroke and peripheral occlusive disease due to vascular occlusion are significant causes of poor prognosis and death. Given the ability of mushroom fibrinolytic enzymes to dissolve blood clots and prevent side effects, their use as a potential thrombolytic therapy has attracted great interest. Serine protease, metalloprotease, and serine metalloprotease are protease enzymes that can affect the fibrinolytic mechanism by dissolving blood clots and increasing blood flow. This systematic review aimed to disclose all information regarding the production, purification, and characterization of fibrinolytic proteases from fungi. Searches were conducted on online media databases, including Google and journal sites (NCBI, PubMed, and others, using the keywords "(Fibrinolytic Enzymes) OR (Fibrinolytic Proteases) AND (Fungi or Mushrooms)" from 2012-2023. This systematic review observed reviews from the purification and characterization steps, indicating the need for attention to the manufacturing process and enzymatic applications. The production of these enzymes by fungi is associated with developments in pharmaceutical applications.
A Generalization of Chio’s Condensation Method
Authors: Muanalifah Any , Sagita Yuli , Nurwan Nurwan , Fitriyah Aini , Jr Rosalio Artes
Published: May 2024

The Chio condensation method is a method to compute the determinant of a matrix A where by reducing the order of the matrix to a matrix. In this paper, we will generalize the condition where can be equal to zero. To compute the determinant, we can choose any element of matrix A that is not equal to zero as a pivot element.
IMPLEMENTASI NILAI MODERASI BERAGAMA DALAM PEMBELAJARAN SEJARAH KEBUDAYAAN ISLAM DI MAN 1 DARUSSALAM CIAMIS
Authors: Jaenudin Mohamad , Suhendi Saca , Hasbiyallah Hasbiyallah , Nasir Tatang Muh
Published: May 2024

The lack of reinforcement of madrasah education causes the flexibility of religious and social values possessed by students, namely the development of extreme ways of thinking and behaving in religion that ignore human values, resulting in problems of intolerance and divisions between religious communities, then there is fanaticism or the development of claims the subjective truth of religious interpretation by rejecting differences and claiming that only one's opinion is right, the others are wrong, whereas what we have to understand is that the different colors of understanding should be a common good. This study aims to explain the Implementation of Religious Moderation Values in learning Islamic Cultural History (SKI) at MAN 1 Darussalam Ciamis. This type of research uses field qualitative with descriptive analysis method, while the data sources of this research consist of madrasa heads, teachers and students with data collection tools including interviews, documentation and observation. The results of the study show that the implementation of religious moderation in Islamic Cultural History (SKI) learning has a very good impact on the formation of student character which is able to reflect an attitude of religious moderation through moderate, fair, tasamuh and ta'awun Islamic cultural learning activities which are reflected in students' attitudes.
STUDYING THE DEVELOPMENT POTENTIAL OF TOURISM INDUSTRIES IN THE SOUTH ALTAI BY HYDROLOGICAL, CLIMATIC, GEOMORPHOLOGICAL WAY AND VISUALIZATION USING GIS
Authors:   Sarsen Amanzholov East Kazakhstan State University, Department of Ecology and Geography, Ust-Kamenogorsk, Kazakhstan, ZHENSIKBAYEVA Nazgul Zh. , ABIYEVA Gulshara ,   Karaganda University named after academician E.A.Buketov, Ust-Kamenogorsk, Kazakhstan, SABYRBAYEVA Botagoz T. ,   Sarsen Amanzholov East Kazakhstan State University, Department of Ecology and Geography, Ust-Kamenogorsk, Kazakhstan, AVGUSTHANOVA Gulzhan A. ,   Sarsen Amanzholov East Kazakhstan State University, Department of Ecology and Geography, Ust-Kamenogorsk, Kazakhstan, KABDRAKHMANOVA Nazym K. ,   Sarsen Amanzholov East Kazakhstan State University, Department of Ecology and Geography, Ust-Kamenogorsk, Kazakhstan, AMANGELDY Nazerke ,   Sarsen Amanzholov East Kazakhstan State University, Department of Ecology and Geography, Ust-Kamenogorsk, Kazakhstan
Published: May 2024

The article conducts a study of the current state of development of the natural and recreational potential of th e Southern Altai. The problems that currently hinder the development of tourism sectors in this territory are considered and ways to solve them are proposed. With the accelerated growth of global tourism and recreation, demand for certain regions of Kazakhstan is increasing. The assessment of the natural and recreational potential of Southern Altai was carried out taking into account the bioclimatic state of natural and recreational areas. When assessing the natural and recreational resources o f the study area, our study assessed the shape of the relief, bioclimate, hydrology and flora. The results of the study allow us to propose specialized and multi-thematic routes connecting the main natural and cultural attractions of the main recreation areas for international and domestic tourists, as well as for educational and educational field programs and research trips. The study of the territorial and recreational potential of a mountainous region has its own characteristics, since, compared with plain territories, its knowledge is insufficient.
The Method in the Madness: Dionysus in the Arts of the Modern Era
Authors: Massini Alexandra
Published: May 2024

This article, derived from my forthcoming book, examines how the irrational was represented through the juxtaposition of Dionysus and Apollo. Ever since Nietzsche’s Geburt der Tragödie, the polarity of the two gods has been codified in Western culture. However, while their discrepancy as opposites has been widely appropriated, little attention has been given to their similarities which can be found in classical art and literature and again from the Renaissance onwards, when Plato’s praise of “madness” was rediscovered, and images of Dionysian character were re-produced. This article briefly traces back the roots of Nietzsche’s ideas and confronts these with examples from the visual arts. It also re-considers the ancient Dionysus and his transformations across time, investigating which aspects of the god were favoured versus others. Bacchus, “id est vinum” recited a popular formula, but from Michelangelo to Caravaggio and beyond, this was not the only Dionysian guise to be known. While often depicted as a merrymaking god of nature, darker aspects could be chosen. It is the madness and disorder, as well as the reasons for their revelation (or omission) that are explored, in the belief that these provided the sources for Nietzsche’s dualistic formulations and many a modern “coniunctio oppositorum”.
Aesthetics of the Fantastic in Pan's Labyrinth
Authors: Panisello Claudia
Published: May 2024

The paper addresses the analysis of aesthetics in Guillermo del Toro's Pan's Labyrinth, a 2006 film in which the fantastic genre predominates. Various aspects are studied: The structure of the plot and composition of the story, which revolve around the presence of two fictional levels: one related to the events of the characters in the mimesis context of the historical and a second fictional level related to the fantastic, producing an understanding of the metaphysical reality of the film. Semiotics of the work in relation to the fantastic regarding the link between Ofelia and the pan. Semiosis of the internal pragmatics of the work in relation to the viewer and the PECMA flow. The acting role of the character Ofelia and her wisdom within the different options presented by the plot. The cultural construction and the attitudinal around gender, are analyzed in relation to their significance. The contribution made by this analysis is an approach to the perceptual process within the film and its relationship with the fantastic. The intervention of the fantastic causes the rupture of the real mimesis, where fantasy allows transgressing the limits of the understanding of the real and generates a character with unusual metaphysical projections.
The Growth of Crayfish, which Serves as an Indicator of Clean and Healthy Water Ecosystems in the Mediterranean Region
Authors: Benzer Semra , Benzer Recep
Published: May 2024

The narrow-fingered freshwater crayfish, also known as Pontastacus leptodactylus in scientific terms and referred to as such in Turkish, is a prevalent species in the inland waters of the Mediterranean region. This crayfish serves as an indicator of clean and healthy water ecosystems due to its high sensitivity to pollution and environmental changes. Its presence signals the maintenance of water quality and a balanced ecosystem. In a study on 283 freshwater crayfish in Hirfanlı Dam Lake during July and August 2023, it was observed that 53.36% were male and 46.64% were female. Length ranged from 80.44 mm to 121.11 mm, and weight varied between 11.61 g and 43.93 g. Average length and weight for males were 95.9874 ± 6.4603 mm and 24.1861 ± 5.3696 g, for females were 95.0981 ± 5.5519 mm and 21.5193 ± 3.4488 g, and for combined sexes were 95.5724 ± 6.0594 mm and 22.9422 ± 4.7579 g. The length-weight relationship (LWR) was established for females (W=0.00166359 ×TL2.0767), males (W=0.00019587×TL2.5651), and all individuals (W=0.00037111 ×TL2.4162). Exponential values "b" for LWR were 2.0767 (r2=0.993), 2.5651 (r2=0.986), and 2.4162 (r2=0.987), respectively. The study compared traditional LWR approaches with artificial intelligence methods for growth analysis, suggesting the latter as a viable alternative in assessing freshwater crayfish growth in aquatic systems.
Blindspots in the Historiography of Russia’s Colonial Rule over South Ukraine and Crimea
Authors: Kravchuk Oleksandr S.
Published: May 2024

The rethinking and decolonization of Russian history has become a significant challenge for historians. This process should cover primarily the history of the Russian empire. The study of different regions of the Russian empire is one of the possible approaches because the empire was heterogeneous. The history of imperial institutions would thus move to the sidelines, while the history of regions, cities, different social, ethnic and religious groups, as well as the interaction within and between them should become the primary focus of historians. This approach would foster a shift from a Moscow-centric view.
Anti-war Russophone Poetry after Feb. 24, 2022: Reinterpreting Russian History and Culture
Authors: Surin Aleksei
Published: May 2024

Since launching a full-scale invasion of Ukraine on February 24th, 2022, Russian authorities have provided several narratives to justify their aggressive actions and war crimes. According to the first, their war is only a response to the actions of the “Nazis”; therefore, the current war is a continuation of the Great Patriotic War in which Russia defeated Hitler. The second asserts the superiority of Russian culture over Ukrainian and explains the attack on Ukraine by the desire to protect the Russian language and culture on Ukrainian territory. Both of these narratives can be categorized as ressentiment, a term coined by Nietzsche that refers to a feeling of hostility towards an individual who is deemed responsible for one’s failures or hardships. This reaction involves glorifying an idealized past and vehemently opposing anything associated with the freedom and cultural values of another. Russophone anti-war poetry written after February 24th, both in Russia and abroad, deconstructs these propaganda narratives and offers its own narrative strategy for talking about Russian history, which I term the poetics of “de-ressentiment.” This essay analyzes anti-war poems by Russian-speaking poets and identifies the principles and tasks of de-ressentiment in the context of Russia’s catastrophic policies. The paper explores how Russian-language anti-war poetry tries to find the right language to discuss the most traumatic topics in Russian history and proposes a total revision of Russian history and culture. This de-ressentiment revision should break free modern Russia’s destructive focus on its past that deprives it of any future.
How the Field was Colonized: Russian History’s Ukrainian Blind Spot
Authors: Smith-Peter Susan , Pollock Sean
Published: May 2024

This discussion seeks to trace the origins of a particularly sympathetic approach to the Russian state and its needs with the field of Russian history in the United States. The response notes some of the major scholars who have greatly influenced the study of Russian history. These include Michael Karpovich, Richard Pipes, and Edward Keenan among others. The discussion grapples with the question of how Russian history in the US has or has not included Ukraine in its narrative and the terms of that incorporation. The original exchange, on H-Russia, comprised the first two commentaries. Susan Smith-Peter’s response was not part of the original H-Russia post. Sean Pollock was not invited to respond.
Analisis Kemampuan Pemahaman Konsep dan Berpikir Kritis Melalui Penerapan Model Pogil dengan Strategi LSQ
Authors: Waskita Prakasa Ibnu , Pratiwi Dona Dinda , Mujib Mujib , Mardiyah Mardiyah
Published: May 2024

Berdasarkan nilai ujian tengah semester matematika, 66,2% siswa mendapatkan nilai di bawah KKM dari total 127 siswa. Pencapaian hasil belajar yang diperoleh siswa menunjukkan kemampuan yang mencerminkan rendahnya pemahaman konsep dan kemampuan berpikir kritis siswa. Mengetahui kemampuan pemahaman konsep dan berpikir kritis siswa yang dipengaruhi oleh penerapan model POGIL dan strategi LSQ menjadi tujuan dalam penelitian ini. Metode penelitian ini adalah eksperimen semu dengan desain yang digunakan adalah posttest kontrol. Instrumen untuk tes dengan analisis data melalui uji normalitas, uji homogenitas, dan uji hipotesis menggunakan MANOVA. Setelah melakukan penelitian dan perhitungan dengan uji MANOVA, diperoleh nilai signifikansi ???? < 0,05. Disimpulkan bahwa model POGIL dengan strategi LSQ mempengaruhi kemampuan pemahaman konsep dan berpikir kritis matematis.
The Challenges of Changing Active to Passive Voice Towards the Third Grade Students of Muhammadiyah Tangerang University
Authors: Hanim Imtihan , Lesmana Bella Putri , Fatimah Fatimah , Sabian Tasya Anjili , Nur Jam Jami Putri Amelia
Published: May 2024

Grammar seems to be an unavoidable challenge for most learners, especially when it comes to acquiring Active to Passive Voice. Active sentences are sentence patterns where the subject does work, and passive sentences are sentence patterns where the subject accepts work. This is a difficult time for English Education students at Muhammadiyah University, Tangerang. The purpose of this research is to find out students' challenges in learning Active to Passive Voice and how they deal with these problems. The selected participants were 12 students from the Intermediate English Grammar Class of 2022. The research method used was qualitative. Data collection was carried out through tests and interviews. The data shows that students have three major difficulties in changing Active to Passive Voice such as placing subjects and objects, using auxiliary verbs, and determining past participles. In addition, two strategies are used by students to overcome learning obstacles. Through understanding formulas to help them master active and passive learning and doing a lot of active and passive exercises to help them better understand the active and passive material.
Peningkatan Partisipasi Guru Pada Pendidikan Dasar Melalui Sertifikasi Guru
Authors: Judijanto Loso , Reza Heru Kreshna , Susanti Melly
Published: May 2024

In the field of education, teachers face latent problems related to economic welfare, so the government is trying to provide a teacher certification program. In an effort to increase teacher engagement in teaching students at the Islamic primary education level, this research will examine teacher certification. This type of research combines literature study methodology with a qualitative approach. Scientific literature which includes books, papers, seminars, and final assignments (thesis, thesis, dissertation) serves as a source of information and material for research analysis. This information comes from reliable sources such as Sinta and Google Scholar. The findings of this study indicate that the implementation of teacher certification is expected to improve teachers' competencies so as to improve educational standards. The four components of competence are; Pedagogical, character, professional, and social mentioned in the government regulation on national education standards (article 28) and the law on teachers and lecturers (article 10).
Enhance the Capacity of Potential Educators to Construct a Comprehensive Understanding of Students with Hearing Impairments by Utilizing Pancasila Principles Through Project-Based Learning
Authors: Mursita Rohmah Ageng , Winarsih Murni , Bintoro Totok , Jaya Indra , Kairunisa Shabila , Tairas Joleta Silvana
Published: May 2024

The objective of this research is to enhance the ability of prospective educators to develop a comprehensive understanding of students with hearing impairments. This study investigates the incorporation of Pancasila principles into a project-based learning framework to meet the educational needs of these students. This study highlights the necessity of providing essential skills and knowledge to prospective teachers to create a conducive classroom environment for students with hearing impairments. This study proposes a unique method to understand and assist students with hearing impairments by integrating Pancasila values into project-based learning. The methodology employed is a mixed methods study to assess the efficacy of this educational approach in enhancing the skills of prospective teachers and the academic achievements of students. The expected outcome is a compilation of principles and tactics that can be utilized by educators to gain a deeper understanding and help children with hearing impairments, thereby fostering collaborative and capacity-building in education.
Pengembangan Media Pembelajaran Interaktif Berbasis Powerpoint pada Pembelajaran IPAS Materi Ada Apa Saja di Bumi Kita Kelas V
Authors: Saputri Alfionita Gea , Kartono Kartono , Salimi Asmayani
Published: May 2024

This research aims to produce a Powerpoint-based Interactive Learning Media product for learning science and science material on What's on Our Earth for grade V elementary schools. The research method used is research and development (RnD) by adapting the ADDIE (Analysis, Design, Development, Implementation, Evaluation) development model. The data sources for this research are the results of validation from two validators, the results of student response questionnaires, the results of practicality questionnaires. The data collection techniques for this research are interviews and questionnaires. The research results show that during the development process of PowerPoint-based interactive learning media, it was carried out in five stages, namely the analysis, design, development, implementation and evaluation stages. The validity of PowerPoint-based interactive learning media products in science and science learning, whatever material there is on our earth, class V of SD Negeri 17 Pontianak City obtained an average of 94.9% in the "very feasible" category. The results of student responses obtained "very good" criteria with an average score of 90.2% in limited trials and 93% in wide-scale trials. The practicality results in the limited trial obtained the criteria "very practical" with an average score of 91.2%. In wide-scale trials, an average of 90.5% was obtained in the "very practical" category. Meanwhile, the teacher's practical results obtained an average score of 100% in the "very practical" category.
Tingkatkan Aktivitas Belajar Geografi: Implementasi Model Project- Based Learning dengan Media Aplikasi Canva di Kelas X SMA N 1 Seririt
Authors: Arita Dewi Kadek Diah , Ananda Citra I Putu , Wesnawa I Gede Astra
Published: May 2024

Student activities in the learning process are not only limited to listening and taking notes.  The more activities students do during learning, the quality of the learning process will increase.  This research aims to examine the impact of the Project-Based Learning model with the support of the Canva application on student learning activities in geography subjects.  The research subjects consisted of five classes  The research design used was One Group Pretest-Posttest Design.  Data collection was carried out through observation and documentation techniques. Data analysis was carried out descriptively and quantitatively, with hypothesis testing using the T-test and simple linear regression test.  The research results show that there is a positive and significant influence from implementing the Project-Based Learning model with the support of the Canva application on student learning activities in geography subjects.
Kedaulatan Negara Indonesia Ditinjau dari Sisi Politik Hukum Pertahanan Negara
Authors: Akbar Rasona Sunara , Mustari Kiki Ananda , Nasa R Dio , Wahyu Feryan , Fadhel Kamal , David Gabriel , Ikhsan Ramadhani
Published: May 2024

National defense is a crucial aspect in maintaining the sovereignty, integrity and security of a country. This discussion reviews various aspects related to national defense, from concept to implementation in law and policy in Indonesia. The research method used is normative analysis of various legal documents and expert views related to national defense. The results of the discussion highlight the importance of integrating military and non-military defense in facing various developing threats. Inter-agency coordination, including through the National Defense Council, is considered crucial in formulating effective defense policies and strategies. In a political context, national defense is seen as the result of the political process and public policy. However, there is also the concept of legal politics which is the basis for determining the laws that apply in a country. In conclusion, national defense requires clear and structured regulations and the involvement of all elements of society to maintain stability and sustainability of defense. Continuous evaluation of the country's defense system is necessary to face the dynamics of ever-growing threats. National defense is an implementation of social contract theory which involves an agreement between citizens in society to protect their rights and obligations and ensure the harmony of interests. Every citizen has the right and obligation to participate in efforts to defend the country, both physically and non-physically, in accordance with the provisions of applicable law. Awareness of the importance of national defense, especially among the younger generation, needs to be increased to ensure their role in advancing the nation is optimal
Pendidikan Politik pada Masyarakat Jawa di Desa Perkebunan Pernantian
Authors: Piswatama Dipo , Pinem Windawati
Published: May 2024

Political education is a scientific study that discusses the political system, constitution, human rights, general elections, political parties, public policy and political participation. Political education refers to how people in remote villages receive attention from the government to provide an understanding of political education. This research focuses on political education in Javanese society in the Pernantian plantation village. This type of research is qualitative. The qualitative research method focuses on interviewing other people outside the environment and is complex. (Moleong, 1999; Creswell, 2002, Lindloft, 1995), states that qualitative research methods are more inductive. This means that the research step that must be prioritized is data based on facts, symptoms, phenomena, reality which is the theme, then processed, processed, so that at the end of the research it can become a proposition, model or even theory. It is hoped that this research will provide awareness of government performance, because remote villages still lack knowledge about political education. The results of the author's findings from fieldwork reveal that, in the plantation villages, the majority of Javanese people spend their time working and do not care about political education and in fact they are very anti-political education.
Assessing Students’ Perception of a YouTube-Based English Learning Resource: A Quantitative Study at MAN 3 Tangerang
Authors: Faiza Childa , Lisma Lestari Viviana
Published: May 2024

The aim of this study was to find out how MAN 3 Tangerang students felt about YouTube videos that were utilized as a English learning resource. A quantitative descriptive research method is employed. An adapted questionnaire was used to collect data for this study utilizing the questionnaire method. Three indicators make up the questionnaire: media practicality, media usability, and accessibility. After that, the research data are examined utilizing the percentation statistical formula. Based on the data analysis results, it is known that students' opinions on English learning materials based on YouTube videos fall into the excellent category, scoring 80 of the total indicators.
Pengaruh Media Sosial terhadap Politik di Desa Holbung, Kecamatan Sitiotio, Kabupaten Samosir
Authors: Siringoringo Agnes Chintya , Ivanna Julia
Published: May 2024

This research discusses the influence of social media on politics in Holbung Village, Sitiotio District, Samosir Regency. With the emergence and development of information technology, people's behavior has experienced a significant transformation in human thought patterns, feelings and actions. Social media is a potential tool for governments to shape public opinion and influence political participation. In the context of a democratic country like Indonesia, public opinion has a crucial role because it is the basis for government function. This study uses a library study method by collecting data through internet searching and documentation studies. Data analysis techniques include data reduction and data display. The research results show that social media plays a vital role in political participation and the formation of public opinion in the digital era, with both good and bad impacts. Nevertheless, the government needs to monitor political activities in the modern social media era. Social media is not only a communication platform, but also a place for information seeking, discussion and networking. This research aims to analyze how social media shapes political knowledge in society using a qualitative descriptive approach. The research results show that social media has a significant influence in engaging, connecting, and mobilizing political participation, although the receipt of political information via social media may vary between individuals.
Analisis Penggunaan Campur Kode Indonesia-Inggris pada Video Iklan Produk Kecantikan Lokal
Authors: Nisa Lira Mey , Simanullang Tiodame Layupa , Haniyah Nabilah Siti , Adawiyah Nijmal , Amelia Octavia , Prasasti Tri Indah
Published: May 2024

This research aims to describe and explain the types and forms of Indonesian-English code mixing used in advertising videos. This study used descriptive qualitative method. The data used in this research are advertising videos on YouTube, especially advertising videos for local beauty products such as Make Over, Avoskin, Emina, Azarine, and Wardah. By watching videos advertising local beauty products on YouTube, researchers then analyzed the types and forms of code mixing used in advertisements. The research results show that the type of code mixing used in advertising videos for local beauty products is Outer Code Mixing. Of the total of 15 advertising videos that we analyzed, there were 50 uses of Indonesian-English code mixing. The forms of code mixing used are Intra sentential code mixing, Intra-lexical code mixing, and Involving a change of pronunciation.
Pengaruh Penempatan Tenaga Kerja oleh Dinas Pendidikan terhadap Tenaga Pendidik dan Kependidikan
Authors: Heliwasnimar Heliwasnimar , Jamilus Jamilus
Published: May 2024

Workplace placement is the process of assigning tasks and jobs to prospective workers who pass the selection to be carried out according to a predetermined scope, and are able to account for all risks and possibilities that occur regarding their duties and work, authority and responsibility, which is also a series of processes. after recruitment and selection to determine positions according to their abilities in order to complete work effectively and efficiently as determined by the organization. In the placement of workers, knowledge and experience and ability are needed in carrying out their duties and if experts are not doing it then there will be destruction or failure, so to achieve success you need the right placement according to their skills. This research is library research and is included in the qualitative research approach. Data collection was carried out directly from various relevant literature, including research articles. Data analysis was carried out qualitatively consisting of data reduction, data presentation, and drawing conclusions. The results of data analysis show that workforce placement influences employee performance in education service agencies.
Dampak Kinerja Yang Dimediasi Oleh Kepuasan Kerja: Pengaruh Remunerasi Dan Pengawasan
Authors: Dwitanto Joko , Afifah Nur , Mustaruddin Mustaruddin
Published: May 2024

This article aims to examine the effect of remuneration and supervision on performance mediated by job satisfaction among the State Civil Apparatus (ASN) at the State Catholic College of Religion in Pontianak. The research was conducted using a quantitative approach. The data collection technique used was the census technique. The number of respondents was 71 people. Data analysis was performed using SPSS with path analysis and Sobel test methods. The results of the analysis showed that: (1) remuneration and supervision, both simultaneously and partially, have a positive and significant effect on job satisfaction, (2) remuneration and job satisfaction, both simultaneously and partially, have a positive and significant effect on performance, while the supervision variable has a negative and significant effect on performance, (3) remuneration has an insignificant effect on performance mediated by employee job satisfaction, and (4) supervision has a positive and significant effect on performance mediated by job satisfaction.
Tingkat Bahaya dan Risiko Bencana Banjir Lahar Dingin Gunung Marapi Berbasis Sistem Informasi Geografis (Sig) Menggunakan Metode Skoring dan Overlay Di Kabupaten Tanah Datar
Authors: Aisy Rahadhatul , Hermon Dedi
Published: May 2024

Penelitian ini bertujuan untuk menganalisis tingkat bahaya dan risiko bencana banjir lahar dingin Gunung Marapi berbasis Sistem Informasi Geografis (SIG) di Kabupaten Tanah Datar. Penelitian ini dilakukan dengan menggunakan teknik analisis pembobotan skoring dan Overlay. Dalam penelitian ini, dilakukan pemetaan bahaya dan analisis risiko dengan mengintegrasikan data spasial dari beberapa faktor ancaman, kerentanan, dan kapasitas. Hasil penelitian ini menunjukan: 1) Peta bahaya banjir lahar dingin ini memetakan jalur banjir lahar dingin yang akan terjadi di Daerah Aliran Sungai (DAS) yang berhulu dari lereng Gunung Marapi. Daerah yang rawan banjir lahar dingin dengan jarak 300 M dari tepi sungai yang berhulu di lereng Gunung Marapi, dengan kelas tinggi memiliki luas 27.480 Ha. 2) Analisis risiko bencana banjir lahar gunung Marapi dilihat dari ancaman, kerentanan, dan kapasitas kemudian dilakukan overlay dan didapatkan nilai risiko rendah berada di Kecamatan Pariangan, Lima Kaum, Sungai Tarab, Salimpaung, dan Tanjung Baru dengan jumlah sebesar 14.646,31 Ha. Untuk luas kawasan risiko bencana sedang terdapat hampir di semua kecamatan yang ada di Kabupaten Tanah Datar dengan jumlah 20.571,1 Ha. Kecamatan yang memiliki kawasan risiko tinggi yaitu X Koto, Batipuh, dan sedikit Kecamatan Pariangan dengan luas 12.448,57 ha.
UV-Inactivated rVSV-M2e-Based Influenza Vaccine Protected against the H1N1 Influenza Challenge
Authors: Olukitibi Titus Abiola , Ao Zhujun , Azizi Hiva , Ouyang Maggie J , Omole Tosin , McKinnon Lyle , Kobasa Darwyn , Coombs Kevin , Kobinger Gary , Yao Xiaojian
Published: May 2024

Background: To investigate the immune responses and protection ability of ultraviolet light (UV)-inactivated recombinant vesicular stomatitis (rVSV)-based vectors that expressed a fusion protein consisting of four copies of the influenza matrix 2 protein ectodomain (tM2e) and the Dendritic Cell (DC)-targeting domain of the Ebola Glycoprotein (EΔM), (rVSV-EΔM-tM2e). Method: In our previous study, we demonstrated the effectiveness of rVSV-EΔM-tM2e to induce robust immune responses against influenza M2e and protect against lethal challenges from H1N1 and H3N2 strains. Here, we used UV to inactivate rVSV-EΔM-tM2e and tested its immunogenicity and protection in BALB/c mice from a mouse-adapted H1N1 influenza challenge. Using Enzyme-Linked Immunosorbent Assay (ELISA) and Antibody-Dependent Cellular Cytotoxicity (ADCC), the influenza anti-M2e immune responses specific to human, avian and swine influenza strains induced were characterized. Likewise, the specificity of the anti-M2e immune responses induced in recognizing M2e antigen on the surface of the cell was investigated using Fluorescence-Activated Cell Sorting (FACS) analysis. Results: Like the live attenuated rVSV-EΔM-tM2e, the UV-inactivated rVSV-EΔM-tM2e was highly immunogenic against different influenza M2e from strains of different hosts, including human, swine, and avian, and protected against influenza H1N1 challenge in mice. The FACS analysis demonstrated that the induced immune responses can recognize influenza M2 antigens from human, swine and avian influenza strains. Moreover, the rVSV-EΔM-tM2e also induced ADCC activity against influenza M2e from different host strains. Conclusions: These findings suggest that UV-inactivated rVSV-EΔM-tM2e could be used as an inactivated vaccine against influenza viruses.
Exploring the S Protein of SARS-CoV-2 to Design a Novel Multi-Epitope Vaccine against COVID-19 Based on Immunoinformatics Approaches
Authors: Huang Zhuanqing , Shi Haoyuan , Gong Hui , Sun Qi , Yang Sen , Zhang Ying , Shi Zhenwei , Xia Zhifa , Huang Songtao , Yao Shusen , Xu Fenghua
Published: May 2024

Background: Developing a novel COVID-19 multi-epitope vaccine (CoVMEV) is essential to containing the SARS-CoV-2 pandemic. Methods: The virus’s immunodominant B and T cell epitopes from the S protein were found and joined to create the CoVMEV. Bioinformatics techniques were used to investigate the secondary and tertiary structures, as well as the physical and chemical properties of CoVMEV. Results: CoVMEV exhibited high antigenicity and immunogenicity scores, together with good water solubility and stability. Toll-like receptor 2 (TLR2) and toll-like receptor4 (TLR4), which are critical in triggering immunological responses, were also strongly favoured by CoVMEV. Molecular dynamics simulation and immune stimulation studies revealed that CoVMEV effectively activated T and B lymphocytes, and increased the number of active CD8+ T cells than similar vaccines. Conclusion: CoVMEV holds promise as a potential vaccine candidate for COVID-19, given its robust immunogenicity, stability, antigenicity, and capacity to stimulate a strong immune response. This study presents a significant design concept for the development of peptidyl vaccines targeting SARS-CoV-2. Further investigation and clinical trials will be crucial in assessing the efficacy and safety of CoVMEV as a potential vaccine for COVID-19.
A Novel Photosensitizer Based 450-nm Blue Laser-Mediated Photodynamic Therapy Induces Apoptosis in Colorectal Cancer – in Vitro and in Vivo Study
Authors: Mei Yibo , Gu Lijiang , Chen Yuhang , Zhang Pan , Cheng Yifan , Yuan Renfei , Li Xing , Wang Xinyang , Guo Peng , He Dalin , Zeng Jin
Published: May 2024

Background: Due to its non-invasive and widely applicable features, photodynamic therapy (PDT) has been a prominent treatment approach against cancer in recent years. However, its widespread application in clinical practice is limited by the dark toxicity of photosensitizers and insufficient penetration of light sources. This study assessed the anticancer effects of a novel photosensitizer 5-(4-amino-phenyl)-10,15,20-triphenylporphyrin with diethylene-triaminopentaacetic acid (ATPP-DTPA)-mediated PDT (hereinafter referred to as ATPP-PDT) under the irradiation of a 450-nm blue laser on colorectal cancer (CRC) in vivo and in vitro. Methods: After 450-nm blue laser-mediated ATPP-PDT and the traditional photosensitizer 5-aminolevulinic acid (5-ALA)-PDT treatment, cell viability was detected through Cell Counting Kit-8 (CCK-8) and 5-ethynyl-2′-deoxyuridine (EdU) assays. Reactive oxygen species (ROS) generation was quantified by flow cytometry and fluorescence microscopy. Western blotting and transcriptome RNA sequencing and functional experiments were used to evaluate cell apoptosis and its potential mechanism. Anti-tumor experiment in vivo was performed in nude mice with subcutaneous tumors. Results: ATPP-DTPA had a marvelous absorption in the blue spectrum. Compared with 5-ALA, ATPP-DTPA could achieve significant killing effects at a lower dose. Owing to generating an excessive amount of ROS, 450-nm blue laser-mediated PDT based on ATPP-DTPA resulted in evident growth inhibition and apoptosis in CRC cells in vitro. After transcriptome RNA sequencing and functional experiments, p38 MAPK signaling pathway was confirmed to be involved in the regulation of apoptosis induced by 450-nm blue laser-mediated ATPP-PDT. Additionally, animal studies using xenograft model confirmed that ATPP-PDT had excellent anti-tumor effect and reasonable biosafety in vivo. Conclusions: PDT mediated by 450-nm blue laser combined with ATPP-DTPA may be a novel and effective method for the treatment of CRC.
Ibrutinib Contributes to Atrial Arrhythmia through the Autophagic Degradation of Connexins by Inhibiting the PI3K-AKT-mTOR Signaling Pathway
Authors: Qin Huiyuan , Zheng Bingyu , Lin Zhiqiao , Ji Yumeng , Wang Cheng , Zhu Huayuan , Cui Chang , Wang Zidun , Chen Minglong
Published: May 2024

Background: Ibrutinib could increase the risk of atrial fibrillation (AF) in chronic lymphocytic leukemia (CLL) patients. However, the precise mechanism underlying ibrutinib-induced AF remains incompletely elucidated. Methods: We investigated the proportion of ibrutinib-treated CLL patients with new-onset AF. Optical mapping was conducted to reveal the proarrhythmic effect of ibrutinib on HL-1 cells. Fluorescence staining and western blot were used to compare connexins 43 and 40 expression in ibrutinib-treated and control groups. To identify autophagy phenotypes, we used western blot to detect autophagy-related proteins, transmission electron microscopy to picture autophagosomes, and transfected mCherry-GFP-LC3 virus to label autophagosomes and lysosomes. Hydroxychloroquine as an autophagy inhibitor was administered to rescue ibrutinib-induced Cx43 and Cx40 degradation. Results: About 2.67% of patients developed atrial arrhythmias after ibrutinib administration. HL-1 cells treated with ibrutinib exhibited diminished conduction velocity and a higher incidence of reentry-like arrhythmias compared to controls. Cx43 and Cx40 expression reduced along with autophagy markers increased in HL-1 cells treated with ibrutinib. Inhibiting autophagy upregulated Cx43 and Cx40. Conclusions: The off-target effect of ibrutinib on the PI3K-AKT-mTOR signaling pathway caused connexin degradation and atrial arrhythmia via promoting autophagy. Clinical Trial Registration: ChiCTR2100046062, https://clin.larvol.com/trial-detail/ChiCTR2100046062.
Diagnostic and Prognostic Value of Plasma lncRNA SRA1 in Chronic Heart Failure
Authors: Yu Yiming , Ge Xiao , Cao Lifang , Li Feng
Published: May 2024

Background: The pathogenesis and development of chronic heart failure (CHF) may involve long non-coding ribonucleic acid (lncRNA) steroid receptor RNA activator 1 (SRA1), a known cardiomyopathy risk factor and regulator of cardiac myofibroblast activation. This study aimed to investigate the application of SRA1 in the early detection and prediction of CHF. Methods: SRA1 plasma expression was determined in CHF patients and healthy individuals/using real time-quantitative polymerase chain reaction (RT-qPCR). The diagnostic and prognostic value of SRA1 was assessed using receiver operating curve (ROC) and Cox regression analyses. Results: Compared with the healthy controls, the patients with CHF had increased brain natriuretic peptide (BNP) levels, left atrial end-systolic diameter (LAD), left ventricular end-diastolic diameter (LVDd), and decreased left ventricular ejection fraction (LVEF). SRA1 was significantly upregulated in CHF patients as well as positively correlated with BNP level, LAD, and LVDd, and negatively correlated with LVEF. SRA1 could sensitively discriminate CHF patients from healthy individuals and was an independent predictor of adverse event-free survival in CHF patients. Conclusions: Upregulated plasma SRA1 can discriminate patients with CHF from healthy individuals and predict adverse outcomes in CHF patients. Thus, SRA1 is a potential molecular indicator for monitoring chronic heart failure development.
Application of Bovine Pericardium and Expanded Polytetrafluoroethylene Patches in Tricuspid Valvuloplasty after Cardiac Surgery
Authors: Xiao Shuo , Wang Qiuji , Fang Dou , Wang Zhenzhong , Ke Yingjie , Zhang Zhaolong , Li Yuxin , Zhong Lishan , Huang Huanlei
Published: May 2024

Background: Leaflet augmentation is often required to correct an inadequate leaflet size due to leaflet thickening, contracture and junctional fusion in patients with tricuspid valve regurgitation (TR) after left-side valve surgery (LSVS). However, the ideal material for leaflet augmentation remains controversial. This article aims to compare the medium- and long-term results of tricuspid valve repair with bovine pericardium (BP) and expanded Polytetrafluoroethylene (ePTFE) patches for the augmentation of tricuspid leaflets and to compare the durability of the two materials. Methods: From January 2015 to April 2023, a total of 69 patients with severe isolated TR underwent tricuspid valvuloplasty (TVP) by leaflets augmentation with patches in our institute. According to the different types of patches, they were divided into the BP group (n = 44) and the ePTFE group (n = 25). Results: There were 3 perioperative deaths (4.3%), one case was due to low cardiac output syndrome in the BP group, and 2 cases were due to acute respiratory dysfunction syndrome and low cardiac output syndrome in the ePTFE group, respectively. Before discharge, the area of the TR jet on echocardiography decreased from 23.5 ± 9.1 to 4.2 ± 3.4 cm2. One case in each group was found to have increased blood flow velocity at the tricuspid orifice. After discharge, one patient in each group underwent repeat TVP, in the BP group because of shortened chordae and in the ePTFE group because of calcification of the patch. During the entire follow-up period, there were 7 cases of severe TR (10.1%), 5 in the BP group and 2 in the ePTFE group, a total of 5 cases of tricuspid stenosis (7.2%), 4 in the BP group and 1 in the ePTFE group, and a total of 6 deaths (8.7%), 5 in the BP group and 1 in the ePTFE group. Transthoracic ultrasound in a patient with tricuspid stenosis suggests stiff leaflet movement and poor motion. Conclusions: Leaflet patch enlargement can be safely used in tricuspid valve repair, but BP patches carry a risk of reduced flexibility and stiffness of movement, and ePTFE patches carries a risk of calcification.