bluuebunny/crossref_metadata_2025 huggingface dataset:
Catena-[Triaquabis(μ2-1,4-bis(diphenylphosphoryl)butane)nitrato-κ2O-praseodymium(III)] Nitrate Monohydrate Methanol Solvate
Authors: Fern Eilidh S. M. , Lunt Maia I. , Minch Guy D. , Roeterdink Julia , Scheu Rodriguez Ana P. , Smith Charlotte A. , Venters Johnathan J. , McKay Aidan P. , Cordes David B. , Chalmers Brian A.
Published: August 2024

The bidentate ligand, 1,4-bis(diphenlyphosphoryl)butane (dppbO2), was used to prepare a 1D polymeric Pr(III) complex which was characterised by single-crystal X-ray diffraction.
Evaluation of Bonding Behavior between Engineered Geopolymer Composites with Hybrid PE/PVA Fibers and Concrete Substrate
Authors: Ling Yu , Zhang Xiafei , Wu Yanwei , Zou Weiyu , Wang Chuang , Li Chaosen , Li Wen
Published: August 2024

Engineered geopolymer composites (EGCs) exhibit excellent tensile ductility and crack control ability, making them promising for concrete structure repair. However, their widespread use is limited by high costs of reinforcement fiber and a lack of an EGC–concrete interface bonding mechanism. This study investigated a hybrid PE/PVA fiber-reinforced EGC using domestically produced unoiled PVA fibers to replace commonly used PE fibers. The bond performance of the EGC–concrete interface was evaluated through direct tensile and slant shear tests, focusing on the effects of PE fiber content (1%, 2%, and 3%), fiber hybrid ratios (2.0:0.0, 1.5:0.5, 1.0:1.0, 0.5:1.5, and 0.0:2.0), concrete substrate strength (C30, C50, and C70), and the ratio of fly ash (FA) to ground granulated blast furnace slag (GGBS) (6:4, 7:3, and 8:2) on interface bond strength. Results showed that the EGCs’ compressive strength ranged from 77.1 to 108.9 MPa, with increased GGBS content significantly enhancing the compressive strength and elastic modulus. Most of the specimens exhibited strain-hardening behavior after initial cracking. Interface bonding tests revealed that a PE/PVA ratio of 1.0 increased tensile bond strength by 8.5% compared with using 2.0% PE fiber alone. Increasing the PE fiber content, PVA/PE ratio, GGBS content, and concrete substrate strength all improved the shear bond strength. This improvement was attributed to the flexible fibers’ ability to restrict thermo–hydro damage and deflect and blunt microcracks, enhancing the interface’s failure resistance. Cost analysis showed that replacing 50% of the PE fiber in EGC with unoiled PVA fiber reduced costs by 44.2% compared with PE fiber alone, offering the best cost–performance ratio. In summary, hybrid PE/PVA fiber EGC has promising prospects for improving economic efficiency while maintaining tensile ductility and crack-control ability. Future optimization of fiber ratios and interface design could further enhance its potential for concrete repair applications.
Effect of Activated Siliceous Wastes Incorporated as Mineral Admixtures on the Rheological Properties of Cement Paste: Insights into Their Physicochemical Interactions in Suspension
Authors: Shi Linyun , Kuang Jingzhong , Qiu Tingsheng
Published: August 2024

Mechanical grinding is a common method used to enhance the pozzolanic activity of tailings, and these activated tailings can be used as supplementary cementitious materials in cement production. However, the addition of activated tailings usually reduces the workability of cement paste, and the mechanism of influence of different minerals in tailings on workability varies. In this study, three kinds of principal silicate minerals in tailings—quartz, feldspar, and mica—were mechanically activated. The influence of these activated minerals on the rheological properties of cement paste were studied in the absence or presence of PCE (polycarboxylate ether) superplasticizers, and the influence mechanism was investigated using rheology, TOC, contact angles, zeta potential, XPS, ICP-OES, and XRD. The results showed that quartz has the highest fluidity, and mica has the lowest. An increase in hydrophilicity decreased the flowability of the blended cement paste. The increase in the metal cation dissolution rate was the main reason for the decrease in the fluidity of PCE-blended cement pastes. The knowledge gained provides a valuable reference for the utilization of activated tailings in cement production.
Wear Performance Evaluation of Polymer Overlays on Engine Bearings
Authors: Ozdemir Ismail , Bulbul Bahattin , Kiracbedel Ugur , Grund Thomas , Lampke Thomas
Published: August 2024

Modern engine bearing materials encounter the challenge of functioning under conditions of mixed lubrication, low viscosity oils, downsizing, start–stop engines, potentially leading to metal-to-metal contact and, subsequently, premature bearing failure. In this work, two types of polymer overlays were applied to the bearing surface to compensate for extreme conditions, such as excessive loads and mixed lubrication. Two different polymer overlays, created through a curing process on a conventional engine bearing surface with an approximate thickness of 13 µm, were investigated for their friction and wear resistances under a 30 N load using a pin-on-disc setup. The results indicate that the newly developed polymer overlay (NDP, PAI-based coating) surface has a coefficient of friction (COF) of 0.155 and a wear volume loss of 0.010 cm3. In contrast, the currently used polymer overlay (CPO) in this field shows higher values with a COF of 0.378 and a wear volume loss of 0.024 cm3, which is significantly greater than that of the NDP. It was found that, in addition to accurately selecting the ratios of solid lubricants, polymer resins, and wear-resistant hard particle additives (metal powders, metal oxides, carbides, etc.) within the polymer coating, the effective presence of a transfer film providing low friction on the counter surface also played a crucial role.
Blin: A Multi-Task Sequence Recommendation Based on Bidirectional KL-Divergence and Linear Attention
Authors: Bai Yanfeng , Wang Haitao , He Jianfeng
Published: August 2024

Sequence recommendation is a prominent research area within recommender systems, focused on predicting items that users may be interested in by modeling their historical interaction sequences. However, due to data sparsity, user interaction sequences in sequence recommendation are typically short. A common approach to address this issue is filling sequences with zero values, significantly reducing the effective utilization of input space. Furthermore, traditional sequence recommendation methods based on self-attention mechanisms exhibit quadratic complexity with respect to sequence length. These issues affect the performance of recommendation algorithms. To tackle these challenges, we propose a multi-task sequence recommendation model, Blin, which integrates bidirectional KL divergence and linear attention. Blin abandons the conventional zero-padding strategy, opting instead for random repeat padding to enhance sequence data. Additionally, bidirectional KL divergence loss is introduced as an auxiliary task to regularize the probability distributions obtained from different sequence representations. To improve the computational efficiency compared to traditional attention mechanisms, a linear attention mechanism is employed during sequence encoding, significantly reducing the computational complexity while preserving the learning capacity of traditional attention. Experimental results on multiple public datasets demonstrate the effectiveness of the proposed model.
Topology Optimization for Quasi-Periodic Cellular Structures Using Hybrid Moving Morphable Components and the Density Approach
Authors: Xiao Pengfei , Zhou Chunping , Qu Yongxin , Luo Yunfeng , Li Quhao
Published: August 2024

Porous hierarchical structures are extensively utilized in engineering for their high specific strength, enhanced corrosion resistance, and multifunctionality. Over the past two decades, multiscale topology optimization for these structures has garnered significant attention. This paper introduces a novel hybrid MMCs (Moving Morphable Components)–density topology optimization method for quasi-periodic cellular structures. The term ‘quasi-periodic’ refers to microstructures whose different macroscopic points exhibit similar topologies with varying parameters. The primary concept involves using the MMC method to describe microstructural topology, while employing variable density to depict macro layouts. This approach leverages the advantage of MMCs in explicitly describing structural topology alongside the variable density of arbitrary microstructures. Sensitivity analyses of the optimization functions concerning design variables are shown, and a gradient optimization solver is employed to solve the optimization model. The examples effectively show the efficacy of the proposed method, illustrating that quasi-periodic cellular structures outperform single-scale solid structures.
Multitasking Integrated Metasurface for Electromagnetic Wave Modulation with Reflection, Transmission, and Absorption
Authors: Wang Jiayun , Niu Yuanyuan , Zhao Qiang , Shang Yuxue , Wang Yuanhui
Published: August 2024

Accommodating multiple tasks within a tiny metasurface unit cell without them interfering with each other is a significant challenge. In this paper, an electromagnetic (EM) wave modulation metasurface capable of reflection, transmission, and absorption is proposed. This multitasking capability is achieved through a cleverly designed multi-layer structure comprising an EM Wave Shield Layer (ESL), a Polarization Modulation Layer (PML), and a Bottom Plate Layer (BPL). The functionality can be arbitrarily switched by embedding control materials within the structure. Depending on external excitation conditions, the proposed metasurface can realize reflection-type co-planar polarization to cross-polarization conversion, transmission-type electromagnetically induced transparency-like (EIT-like) modes, and broadband absorption. Notably, all tasks operate approximately within the same operating frequency band, and their performance can be regulated by the intensity of external excitation. Additionally, the operating principle of the metasurface is analyzed through impedance matching, an oscillator coupling model, and surface current distribution. This metasurface design offers a strategy for integrated devices with multiple functionalities.
First-Principles Insights into Highly Sensitive and Reusable MoS2 Monolayers for Heavy Metal Detection
Authors: Wu Jiayin , Li Zongbao , Liang Tongle , Mo Qiuyan , Wei Jingting , Li Bin , Xing Xiaobo
Published: August 2024

This study explores the potential of MoS2 monolayers as heavy metal sensors for As, Cd, Hg, and Pb using density functional theory (DFT) and Non-Equilibrium Green’s Function (NEGF) simulations. Our findings reveal that As and Pb adsorption significantly alters the surface structure and electronic properties of MoS2, introducing impurity levels and reducing the band gap. Conversely, Cd and Hg exhibit weaker interactions with the MoS2 surface. The MoS2 monolayer sensors demonstrate exceptional sensitivity for all four target heavy metals, with values reaching 126,452.28% for As, 1862.67% for Cd, 427.71% for Hg, and 83,438.90% for Pb. Additionally, the sensors demonstrate selectivity for As and Pb through distinct response peaks at specific bias voltages. As and Pb adsorption also induces magnetism in the MoS2 system, potentially enabling magnetic sensing applications. The MoS2 monolayer’s moderate adsorption energy facilitates rapid sensor recovery at room temperature for As, Hg, and Cd. Notably, Pb recovery time can be significantly reduced at elevated temperatures, highlighting the reusability of the sensor. These results underscore the potential of MoS2 monolayers as highly sensitive, selective, and regenerable sensors for real-time heavy metal detection.
Highly Sensitive Plasmon Refractive Index Sensor Based on MIM Waveguide
Authors: Jiang Wen , Yan Shubin , Yan Xiaoran , Xu Aiwei , Liu Guang , Wang Chong , Li Lei , Mu Xiangyang , Gao Guowang
Published: August 2024

This paper introduces a novel plasmon refractive index nanosensor structure based on Fano resonance. The structure comprises a metal–insulator–metal (MIM) waveguide with an inverted rectangular cavity and a circle minus a small internal circle plus a rectangular cavity (CMSICPRC). This study employs the finite element method (FEM) to analyze the sensing characteristics of the structure. The results demonstrate that the geometrical parameters of specific structures exert a considerable influence on the sensing characteristics. Simulated experimental data show that the maximum sensitivity of this structure is 3240 nm/RIU, with a figure of merit (FOM) of 52.25. Additionally, the sensor can be used in biology, for example, to detect the concentration of hemoglobin in blood. The sensitivity of the sensor in this application, according to our calculations, can be 0.82 nm∙g/L.
Clot Accumulation in 3D Microfluidic Bifurcating Microvasculature Network
Authors: Belenkovich Merav , Veksler Ruth , Kreinin Yevgeniy , Mekler Tirosh , Flores Mariane , Sznitman Josué , Holinstat Michael , Korin Netanel
Published: August 2024

The microvasculature, which makes up the majority of the cardiovascular system, plays a crucial role in the process of thrombosis, with the pathological formation of blood clots inside blood vessels. Since blood microflow conditions significantly influence platelet activation and thrombosis, accurately mimicking the structure of bifurcating microvascular networks and emulating local physiological blood flow conditions are valuable for understanding blood clot formation. In this work, we present an in vitro model for blood clotting in microvessels, focusing on 3D bifurcations that align with Murray’s law, which guides vascular networks by maintaining a constant wall shear rate throughout. Using these models, we demonstrate that microvascular bifurcations act as sites facilitating thrombus formation compared to straight models. Additionally, by culturing endothelial cells on the luminal surfaces of the models, we show the potential of using our in vitro platforms to recapitulate the initial clotting in diseases involving endothelial dysfunction, such as Thrombotic Thrombocytopenic Purpura.
Customization of Computed Tomography Radio-Opacity in 3D-Printed Contrast-Injectable Tumor Phantoms
Authors: Kalidindi Yuktesh , Ganapathy Aravinda Krishna , Cunningham Liam , Lovato Adriene , Albers Brian , Shetty Anup S. , Ballard David H.
Published: August 2024

Medical Imaging Phantoms (MIPs) calibrate imaging devices, train medical professionals, and can help procedural planning. Traditional MIPs are costly and limited in customization. Additive manufacturing allows for customizable, patient-specific phantoms. This study examines the CT attenuation characteristics of contrast-injectable, chambered 3D-printed phantoms to optimize tissue-mimicking capabilities. A MIP was constructed from a CT of a complex pelvic tumor near the iliac bifurcation. A 3D reconstruction of these structures composed of three chambers (aorta, inferior vena cava, tumor) with ports for contrast injection was 3D printed. Desired attenuations were 200 HU (arterial I), 150 HU (venous I), 40 HU (tumor I), 150 HU (arterial II), 90 HU (venous II), and 400 HU (tumor II). Solutions of Optiray 350 and water were injected, and the phantom was scanned on CT. Attenuations were measured using ROIs. Mean attenuation for the six phases was as follows: 37.49 HU for tumor I, 200.50 HU for venous I, 227.92 HU for arterial I, 326.20 HU for tumor II, 91.32 HU for venous II, and 132.08 HU for arterial II. Although the percent differences between observed and goal attenuation were high, the observed relative HU differences between phases were similar to goal HU differences. The observed attenuations reflected the relative concentrations of contrast solutions used, exhibiting a strong positive correlation with contrast concentration. The contrast-injectable tumor phantom exhibited a useful physiologic range of attenuation values, enabling the modification of tissue-mimicking 3D-printed phantoms even after the manufacturing process.
Implementation of Accurate Parameter Identification for Proton Exchange Membrane Fuel Cells and Photovoltaic Cells Based on Improved Honey Badger Algorithm
Authors: Yu Wei-Lun , Wen Chen-Kai , Liu En-Jui , Chang Jen-Yuan
Published: August 2024

Predicting the system efficiency of green energy and developing forward-looking power technologies are key points to accelerating the global energy transition. This research focuses on optimizing the parameters of proton exchange membrane fuel cells (PEMFCs) and photovoltaic (PV) cells using the honey badger algorithm (HBA), a swarm intelligence algorithm, to accurately present the performance characteristics and efficiency of the systems. Although the HBA has a fast search speed, it was found that the algorithm’s search stability is relatively low. Therefore, this study also enhances the HBA’s global search capability through the rapid iterative characteristics of spiral search. This method will effectively expand the algorithm’s functional search range in a multidimensional and complex solution space. Additionally, the introduction of a sigmoid function will smoothen the algorithm’s exploration and exploitation mechanisms. To test the robustness of the proposed methodology, an extensive test was conducted using the CEC’17 benchmark functions set and real-life applications of PEMFC and PV cells. The results of the aforementioned test proved that with regard to the optimization of PEMFC and PV cell parameters, the improved HBA is significantly advantageous to the original in terms of both solving capability and speed. The results of this research study not only make definite progress in the field of bio-inspired computing but, more importantly, provide a rapid and accurate method for predicting the maximum power point for fuel cells and photovoltaic cells, offering a more efficient and intelligent solution for green energy.
An Integrated Solution to FIB-Induced Hydride Artifacts in Pure Zirconium
Authors: Qiao Yi , Xu Zongwei , Li Shilei , Wang Fu , Huang Yubo
Published: August 2024

The preparation method of transmission electron microscopy (TEM) samples for pure zirconium was successfully executed using a focused ion beam (FIB) system. These samples unveiled artifact hydrides induced during the FIB sample preparation process, which resulted from stress damage, ion implantation, and ion irradiation. An innovative solution was proposed to effectively reduce the effect of artifact hydrides for FIB-prepared samples of hydrogen-sensitive materials, such as zirconium alloys. This development lays the groundwork for further research on the micro/nanostructures of zirconium alloys after ion irradiation, thereby facilitating the study of corrosion mechanisms and the prediction of service life for nuclear fuel cladding materials. Furthermore, the solution proposed in this study is also applicable to TEM sample preparation using FIB for other hydrogen-sensitive materials such as titanium, magnesium, and palladium.
Effects of Group IVA Elements on the Electrical Response of a Ge2Se3-Based Optically Gated Transistor
Authors: Kabir Md Faisal , Campbell Kristy A.
Published: August 2024

The optically gated transistor (OGT) has been previously demonstrated as a viable selector device for memristor devices, and may enable optical addressing within cross-point arrays. The OGT current–voltage response is similar to a MOSFET device, with light activating the gate instead of voltage. The OGT also provides a naturally built-in compliance current for a series resistive memory element, determined by the incident light intensity on the gate, thus keeping the integrated periphery circuitry size and complexity to a minimum for a memory array. The OGT gate comprises an amorphous Ge2Se3 material that can readily be doped with other elements to alter the transistor’s electrical properties. In this work, we explore the operation of the OGT when the Ge2Se3 gate material is doped with the Group IVA elements C, Si, Sn, and Pb. The dopant atoms provide changes to the optical and electrical properties that allow key electrical properties such as the dark current, photocurrent, switching speed, and threshold voltage to be tuned.
Role of Carbon, Nitrogen, Phosphate and Sulfur Metabolism in Secondary Metabolism Precursor Supply in Streptomyces spp.
Authors: Krysenko Sergii , Wohlleben Wolfgang
Published: August 2024

The natural soil environment of Streptomyces is characterized by variations in the availability of nitrogen, carbon, phosphate and sulfur, leading to complex primary and secondary metabolisms. Their remarkable ability to adapt to fluctuating nutrient conditions is possible through the utilization of a large amount of substrates by diverse intracellular and extracellular enzymes. Thus, Streptomyces fulfill an important ecological role in soil environments, metabolizing the remains of other organisms. In order to survive under changing conditions in their natural habitats, they have the possibility to fall back on specialized enzymes to utilize diverse nutrients and supply compounds from primary metabolism as precursors for secondary metabolite production. We aimed to summarize the knowledge on the C-, N-, P- and S-metabolisms in the genus Streptomyces as a source of building blocks for the production of antibiotics and other relevant compounds.
In Silico Analysis and Development of the Secretory Expression of D-Psicose-3-Epimerase in Escherichia coli
Authors: Watthanasakphuban Nisit , Ninchan Boontiwa , Pinmanee Phitsanu , Rattanaporn Kittipong , Keawsompong Suttipun
Published: August 2024

D-psicose-3-epimerase (DPEase), a key enzyme for D-psicose production, has been successfully expressed in Escherichia coli with high yield. However, intracellular expression results in high downstream processing costs and greater risk of lipopolysaccharide (LPS) contamination during cell disruption. The secretory expression of DPEase could minimize the number of purification steps and prevent LPS contamination, but achieving the secretion expression of DPEase in E. coli is challenging and has not been reported due to certain limitations. This study addresses these challenges by enhancing the secretion of DPEase in E. coli through computational predictions and structural analyses. Signal peptide prediction identified PelB as the most effective signal peptide for DPEase localization and enhanced solubility. Supplementary strategies included the addition of 0.1% (v/v) Triton X-100 to promote protein secretion, resulting in higher extracellular DPEase (0.5 unit/mL). Low-temperature expression (20 °C) mitigated the formation of inclusion bodies, thus enhancing DPEase solubility. Our findings highlight the pivotal role of signal peptide selection in modulating DPEase solubility and activity, offering valuable insights for protein expression and secretion studies, especially for rare sugar production. Ongoing exploration of alternative signal peptides and refinement of secretion strategies promise further enhancement in enzyme secretion efficiency and process safety, paving the way for broader applications in biotechnology.
New Structure of Aeromonas salmonicida O-Polysaccharide Isolated from Ill Farmed Fish
Authors: Ucieklak Karolina , Wojtys-Tekiel Sylwia , Leroy Garance , Le Devendec Laëtitia , Baron Sandrine , Kaszowska Marta
Published: August 2024

The diversity of O-polysaccharides (O-antigens) among 28 Aeromonas salmonicida strains isolated from ill fish has been determined by using high-resolution magic angle spinning (HR MAS) NMR spectroscopy. The new O-polysaccharide has been identified in two isolates. This new structure was investigated by 1H and 13C NMR spectroscopy and matrix-assisted laser-desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). The following structure of the linear hexasaccharide repeating unit of A. salmonicida O-antigen has been established: →3)-α-L-Rhap-(1→3)-α-D-ManpNAc-(1→2)-β-D-Glcp-(1→3)-α-L-Rhap2OAc4OAc-(1→3)-β-D-ManpNAc-(1→3)-α-D-Glcp-(1→. This new A. salmonicida O-polysaccharide was detected among two isolates collected from trout and turbot fish in 2010 and 2011, respectively. Further investigations should be conducted to evaluate the distribution of this new O-polysaccharide among a larger collection of isolates, depending on their geographic origin, the species of fish, and the health status of the fish.
Ethyl Acetate Fraction from Eleutherococcus divaricatus Root Extract as a Promising Source of Compounds with Anti-Hyaluronidase, Anti-Tyrosinase, and Antioxidant Activity but Not Anti-Melanoma Activity
Authors: Gębalski Jakub , Małkowska Milena , Wnorowska Sylwia , Gawenda-Kempczyńska Dorota , Strzemski Maciej , Wójciak Magdalena , Słomka Artur , Styczyński Jan , Załuski Daniel
Published: August 2024

Eleutherococcus divaricatus (Siebold and Zucc.) S. Y. Hu. has been used in Traditional Chinese Medicine (TCM) due to its anticancer, immunostimulant, and anti-inflammatory activities. However, its mechanism of action and chemical composition are still insufficiently understood and require more advanced research, especially for cases in which anti-inflammatory properties are beneficial. The aim of this study was to evaluate the impact of E. divaricatus root extracts and fractions on proinflammatory serum hyaluronidase and tyrosinase in children diagnosed with acute lymphoblastic leukemia. Antioxidant and anti-melanoma activities were also examined and correlated with metabolomic data. For the first time, we discovered that the ethyl acetate fraction significantly inhibits hyaluronidase activity, with mean group values of 55.82% and 63.8% for aescin used as a control. However, interestingly, the fraction showed no activity against human tyrosinase, and in A375 melanoma cells treated with a doxorubicin fraction, doxorubicin activity decreased. This fraction exhibited the most potent antioxidant activity, which can be attributed to high contents of polyphenols, especially caffeic acid (24 mg/g). The findings suggest an important role of the ethyl acetate fraction in hyaluronidase inhibition, which may additionally indicate its anti-inflammatory property. The results suggest that this fraction can be used in inflammatory-related diseases, although with precautions in cases of patients undergoing chemotherapy.
Hydrothermal Synthesis of β-NiS Nanoparticles and Their Applications in High-Performance Hybrid Supercapacitors
Authors: Liu Xiaohong , Wang Yulin , Luo Chunwang , Zhang Zheyu , Sun Hongyan , Xu Chunju , Chen Huiyu
Published: August 2024

In this work, β-NiS nanoparticles (NPs) were efficiently prepared by a straightforward hydrothermal process. The difference in morphology between these NiS NPs was produced by adding different amounts of thiourea, and the corresponding products were denoted as NiS-15 and NiS-5. Through electrochemical tests, the specific capacity (Cs) of NiS-15 was determined to be 638.34 C g−1 at 1 A g−1, compared to 558.17 C g−1 for NiS-5. To explore the practical application potential of such β-NiS NPs in supercapacitors, a hybrid supercapacitor (HSC) device was assembled with activated carbon (AC) as an anode. Benefitting from the high capacity of the NiS cathode and the large voltage window of the device, the NiS-15//AC HSC showed a high energy density (Ed) of 43.57 W h kg−1 at 936.92 W kg−1, and the NiS-5//AC HSC provided an inferior Ed of 37.89 W h kg−1 at 954.79 W kg−1. Both HSCs showed excellent cycling performance over 6000 cycles at 10 A g−1. The experimental findings suggest that both NiS-15 and NiS-5 in this study can serve as potential cathodes for high-performance supercapacitors. This current synthesis method is simple and can be extended to the preparation of other transition metal sulfide (TMS)-based electrode materials with exceptional electrochemical properties.
Challenges in LncRNA Biology: Views and Opinions
Authors: Adjeroh Donald A. , Zhou Xiaobo , Paschoal Alexandre Rossi , Dimitrova Nadya , Derevyanchuk Ekaterina G. , Shkurat Tatiana P. , Loeb Jeffrey A. , Martinez Ivan , Lipovich Leonard
Published: August 2024

This is a mini-review capturing the views and opinions of selected participants at the 2021 IEEE BIBM 3rd Annual LncRNA Workshop, held in Dubai, UAE. The views and opinions are expressed on five broad themes related to problems in lncRNA, namely, challenges in the computational analysis of lncRNAs, lncRNAs and cancer, lncRNAs in sports, lncRNAs and COVID-19, and lncRNAs in human brain activity.
Late-Life Blood Pressure and Cerebral Amyloid Angiopathy: Findings from the U.S. National Alzheimer’s Coordinating Center Uniform Dataset
Authors: Sin Mo-Kyung , Dowling N. , Roseman Jeffrey , Ahmed Ali , Zamrini Edward
Published: August 2024

High blood pressure (BP) and cerebral amyloid angiopathy (CAA) are two common risk factors for intracranial hemorrhage, potentially leading to cognitive impairment. Less is known about the relationship between BP and CAA, the examination of which was the objective of this study. We analyzed data from 2510 participants in the National Alzheimer’s Coordinating Center (NACC) who had information on longitudinal BP measurements before death and on CAA from autopsy. Using the average of four systolic BPs (SBPs) prior to death, SBP was categorized into three groups: <120 mmHg (n = 435), 120–139 mmHg (n = 1335), and ≥140 mmHg (n = 740). CAA was diagnosed using immunohistochemistry in 1580 participants and categorized as mild (n = 759), moderate (n = 529), or severe (n = 292). When adjusted for age at death, sex, APOE genotype, Braak, CERAD, antihypertensive medication use, and microinfarcts, the odds ratios (95% CIs) for CAA associated with SBPs of 120–139 and ≥140 mmHg were 0.91 (0.74–1.12) and 1.00 (0.80–1.26), respectively. Findings from predictor effect plots show no variation in the probability of CAA between the three SBP categories. Microbleeds had no association with CAA, but among those with SBP ≥ 130 mmHg, the proportion of those with microbleeds was numerically greater in those with more severe CAA (p for trend, 0.084). In conclusion, we found no evidence of an association between SBP and CAA. Future studies need to develop non-invasive laboratory tests to diagnose CAA and prospectively examine this association and its implication on the pathophysiology and outcome of Alzheimer’s disease.
The Outcome of Metabolic and Bariatric Surgery in Morbidly Obese Patients with Different Genetic Variants Associated with Obesity: A Systematic Review
Authors: Zafirovska Marija , Zafirovski Aleksandar , Režen Tadeja , Pintar Tadeja
Published: August 2024

Metabolic and bariatric surgery (MBS) effectively treats obesity and related comorbidities, though individual responses vary. This systematic review examines how genetic variants influence MBS outcomes in morbidly obese patients. A comprehensive search in PubMed, Embase, Medline, and the Cochrane Library identified 1572 studies, with 52 meeting the inclusion criteria. Two reviewers independently filtered and selected studies, including relevant cross-references. Research focused on polymorphisms in genes such as UCP2, UCP3, 5-HT2C, MC4R, FKBP5, FTO, CAT haplotypes, LYPAL-1, PTEN, FABP-2, CNR1, LEP656, LEP223, GLP-1R, APOA-1, APOE, ADIPOQ, IL-6, PGC1a, TM6SF2, MBOAT7, PNPLA3, TCF7L2, ESR1, GHSR, GHRL, CD40L, DIO2, ACSL5, CG, TAS2R38, CD36, OBPIIa, NPY, BDNF, CLOCK, and CAMKK2. Most studies explored associations with post-surgery weight loss, while some examined metabolic, cardiovascular, taste, and eating behavior effects as well. Understanding the role of genetic factors in weight loss and metabolic outcomes post-MBS can help tailor personalized treatment plans for improved efficacy and long-term success. Further research with larger sample sizes and extended follow-up is needed to clarify the effects of many genetic variants on MBS outcomes in morbidly obese patients.
Salt Reduction and Iodine Fortification Policies Are Compatible: Perspectives for Public Health Advocacy
Authors: Rigutto-Farebrother Jessica , Zimmermann Michael B.
Published: August 2024

Cardiovascular diseases account for almost 18 million deaths annually, the most of all non-communicable diseases. The reduction of dietary salt consumption is a modifiable risk factor. The WHO recommends a daily sodium intake of <2000 mg but average consumption exceeds this in many countries globally. Strategies proposed to aid effective salt reduction policy include product reformulation, front of pack labelling, behavioural change campaigns and establishing a low-sodium-supportive environment. Yet, salt for household and processed food use is, in countries wholly or partially adopting a universal salt iodisation policy, the principal vehicle for population-wide iodine fortification. With salt reduction policies in place, there is concern that iodine deficiency disorders may re-emerge. Recognising the urgency to tackle the rising prevalence of NCDs yet not risk the re-emergence and detrimental effect of inadequate iodine intakes, this review lays out the feasibility of integrating both salt reduction and salt iodine fortification strategies. Reducing the burden of health risks associated with an excessive sodium intake or inadequate iodine through population-tailored, cost-effective strategies involving salt is both feasible and achievable, and represents an opportunity to improve outcomes in public health.
Chitosan/Hesperidin Nanoparticles for Sufficient, Compatible, Antioxidant, and Antitumor Drug Delivery Systems
Authors: Almukainzi May , El-Masry Thanaa A. , El Zahaby Enas I. , El-Nagar Maysa M. F.
Published: August 2024

One flavonoid glycoside with demonstrated therapeutic potential for several illnesses, including cancer, is hesperidin. However, because of its limited bioavailability and solubility, it is only marginally absorbed, necessitating a delivery mechanism to reach the intended therapeutic target. Additionally, the cytoskeleton of crustaceans yields chitosan, a naturally occurring biopolymer with mucoadhesive properties that has been used to improve the absorption of advantageous chemical substances like flavonoids. Chitosan/hesperidin nanoparticles (Hes-Nanoparticles) were made using the ion gelation technique. The synthesis of Hes-Nanoparticles was confirmed by several characterization methods, including the swelling test, zeta potential, particle size, FTIR, XRD, TEM, and SEM. DPPH and ABTS were used to demonstrate radical scavenging activity in antioxidant assays of chitosan, hesperidin, and the synthesized Hes-Nanoparticles. In addition, by a viability assay against MDA-MB-231, the anticancer efficacies of chitosan, hesperidin, and the synthesized Hes-Nanoparticles were assessed. Furthermore, annexin-V/PI double staining and the cycle of cell analysis were determined by flow cytometry. The results displayed that Hes-Nanoparticles have higher antioxidant activity than chitosan and hesperidin alone. Also, it has been demonstrated that Hes-Nanoparticles are more effective in early cell cycle arrest, suppressing the viability of cancer cells, and increasing cell apoptosis than chitosan and hesperidin alone. In conclusion, Hes-Nanoparticles demonstrated more antioxidant and antitumor activities than chitosan and hesperidin alone. Moreover, it has been established that Hes-Nanoparticles, in a highly soluble form, increase activity in contrast to the poorly soluble form of hesperidin alone.
In Silico Screening Identification of Fatty Acids and Fatty Acid Derivatives with Antiseizure Activity: In Vitro and In Vivo Validation
Authors: Barrionuevo Emilia Mercedes , Peralta Estefanía , Manzur De Nardi Agustín , Monat Juliana , Fallico Maximiliano José , Llanos Manuel Augusto , Gavernet Luciana , Mustafá Emilio Román , Martin Pedro , Talevi Alan
Published: August 2024

High fat diets have been used as complementary treatments for seizure disorders for more than a century. Moreover, many fatty acids and derivatives, including the broad-spectrum antiseizure medication valproic acid, have been explored and used as pharmacological agents to treat epilepsy. In this work, we have explored the anticonvulsant potential of a large library of fatty acids and fatty acid derivatives, the LIPID MAPS Structure Database, using structure-based virtual screening to assess their ability to block the voltage-gated sodium channel 1.2 (NaV1.2), a validated target for antiseizure medications. Four of the resulting in silico hits were submitted for experimental confirmation using in vitro patch clamp experiments, and their protective role was evaluated in an acute mice seizure model, the Maximal Electroshock seizure model. These four compounds were found to protect mice against seizures. Two of them exhibited blocking effects on NaV1.2, CaV2.2, and CaV3.1.
In Vitro Studies to Evaluate the Intestinal Permeation of an Ursodeoxycholic Acid-Conjugated Oligonucleotide for Duchenne Muscular Dystrophy Treatment
Authors: Faiella Marika , Botti Giada , Dalpiaz Alessandro , Gnudi Lorenzo , Goyenvalle Aurélie , Pavan Barbara , Perrone Daniela , Bovolenta Matteo , Marchesi Elena
Published: August 2024

Delivery represents a major hurdle to the clinical advancement of oligonucleotide therapeutics for the treatment of disorders such as Duchenne muscular dystrophy (DMD). In this preliminary study, we explored the ability of 2′-O-methyl-phosphorothioate antisense oligonucleotides (ASOs) conjugated with lipophilic ursodeoxycholic acid (UDCA) to permeate across intestinal barriers in vitro by a co-culture system of non-contacting IEC-6 cells and DMD myotubes, either alone or encapsulated in exosomes. UDCA was used to enhance the lipophilicity and membrane permeability of ASOs, potentially improving oral bioavailability. Exosomes were employed due to their biocompatibility and ability to deliver therapeutic cargo across biological barriers. Exon skipping was evaluated in the DMD myotubes to reveal the targeting efficiency. Exosomes extracted from milk and wild-type myotubes loaded with 5′-UDC-3′Cy3-ASO and seeded directly on DMD myotubes appear able to fuse to myotubes and induce exon skipping, up to ~20%. Permeation studies using the co-culture system were performed with 5′-UDC-3′Cy3-ASO 51 alone or loaded in milk-derived exosomes. In this setting, only gymnotic delivery induced significant levels of exon skipping (almost 30%) implying a possible role of the intestinal cells in enhancing delivery of ASOs. These results warrant further investigations to elucidate the delivery of ASOs by gymnosis or exosomes.
Risk Characterization in Patients Using Benzodiazepines While Providing Pharmaceutical Care Dispensing Service
Authors: Alberto Armas Daida , Hernández García Verónica , Román Castillo Yanira , Santana Ayala Juan Ramón , Capdevila Finestres Franc , Hardisson de la Torre Arturo , Rubio Armendáriz Carmen
Published: August 2024

Background: Tolerance and dependence stand out as the most relevant risks observed during benzodiazepine (BZD) treatments. Objectives: To evaluate the degree of dependence of patients on BZD treatments using the Tyrer test; to define a profile of patients at risk of developing BZD dependence; and to discuss the role of the pharmaceutical care offered by the community pharmacy during dispensing. Methods: Prospective cross-sectional descriptive observational study (August 2020–February 2021) involving 127 patients using BZD. They voluntarily answered a questionnaire during the dispensing pharmaceutical care service. The study was evaluated and codified (code: DAA-CLO-2020-01) by the Spanish Agency for Drugs and Health Products (AEMPS), and statistical analysis was performed with SPSS 25.0. Results: 19.05% of patients using BZD were suspected of suffering from BZD tolerance, and 77.88% of all patients were identified as being at a high risk of BZD dependence. The Tyrer test for dependence indicated a mean score of 5.59 out of 13 points. An 18-fold increased risk of developing dependence was detected in the case of coexistence of high anxiety or depression. Conclusions: The community pharmacy, through protocolized care practices and supported by tools such as the Tyrer test, can play a decisive role in the detection, prevention, and resolution of the risks associated with BZD treatments.
A Review of Indoor Optical Wireless Communication
Authors: Weng Huiyi , Wang Wei , Chen Zhiwei , Zhu Bowen , Li Fan
Published: August 2024

Indoor Optical Wireless Communication (OWC) provides a promising solution for high-capacity, low-latency, and electromagnetic interference-resistant wireless communication. Over the past decade, there has been extensive research addressing key challenges in indoor OWC. This article provides an overview of the current development status, key technologies, and challenges faced in the field of indoor OWC. Furthermore, at the end of this overview, an experimental demonstration of an indoor non-line-of-sight (NLOS) OWC system utilizing a spatial light modulator (SLM) for beam steering is demonstrated, which is expected to inspire research on related technologies.
Stress Wave Propagation and Decay Based on Micro-Scale Modelling in the Topology of Polymer Composite with Circular Particles
Authors: Sabol Dominik , Murčinková Zuzana
Published: August 2024

This article deals with stress wave decay performance, analysing the stress wave propagation generated by an impulsive unit load in a 2D representative unit cell (RUC) of a polymer composite with circular particles representing spherical particles, elliptical particles, and short fibres. The micro-scale numerical simulation uses explicit finite element analysis (FEA). The micro-response to an impulsive unit load creates a stress wave amplitude interacting with the material structure and tends to weaken and absorb energy. The stress wave damping is determined by the decaying amplitudes of Mises stress at the front of the stress wave. The stress wave damping is evaluated for different ratios of tensile modules and material densities of matrix and reinforcing material and other factors, such as percentage and particle size, applied to nine topologies of RUCs, and even the presence of an interfacial region is analysed. Moreover, the article visualises the phases of stress wave decay in various particle distributions, i.e., various topologies. Analysing the different topologies of the same particle volume (area) percentage, the study proved that the composite topology and resulting wave–particle and wave–wave interactions are other sources of material damping. The presence of even a small percentage, 3.5 area%, of reinforcing circular particles in the matrix brings a significant increase in stress wave damping up to about 40–43% (depending on the topology) compared to a homogeneous matrix with stress wave damping of 12.5% under the same conditions. Moreover, the topology with the same volume (area) percentage can increase particle stress wave damping by 15.3%.
Stabilization of Fish Protein-Based Adhesive by Reduction of Its Hygroscopicity
Authors: Mušič Branka , Pečnik Jaka Gašper , Pondelak Andreja
Published: August 2024

Protein-based fish adhesives have historically been used in various bonding applications; however, due to the protein’s high affinity for water absorption, these adhesives become destabilized in high-moisture environments, resulting in reduced bondline strength and early failure. This limitation makes them unsuitable for industrial applications with higher demands. To address this issue, water-insoluble raw powder materials such as iron, copper, or zeolite were incorporated into natural fish adhesives. In this study, the hygroscopicity, dry matter content, thermal analysis (TGA/DSC), FT-IR spectroscopy, surface tension measurements, vapour permeability, and scanning electron microscope (SEM) of the modified adhesives were determined. In addition, the bonding properties of the modified adhesives were evaluated by the tensile shear strength of the lap joints, and mould growth was visually inspected. The resulting modified protein-based adhesives demonstrated improved stability in high humidity environments. Enhancing the hygroscopic properties of protein-based fish adhesives has the potential to unlock new opportunities and applications, providing a healthier and more environmentally sustainable alternative to petroleum-based adhesives.
Marine Mannitol: Extraction, Structures, Properties, and Applications
Authors: Hosseini Seyed Vali , Dastgerdi Hajar Ebrahimi , Tahergorabi Reza
Published: August 2024

Mannitol is the most abundant polyol in nature and has wide commercial applications due to its properties in the food, chemical, medical, and pharmaceutical industries. Mannitol was traditionally produced from kelp, but this process was eliminated due to high water and energy consumption and gradually replaced by methods with less energy consumption and environmentally friendly practices. Studies show that brown seaweed contains large amounts of mannitol. Therefore, this paper intends to describe the structure of this sugar alcohol present in brown algae, its commercial production, and its biosynthetic pathway in algae, as well as its medical and nutritional applications.
“Religious Education for All 2.0”: The Hamburg Approach of Shared Religious Education
Authors: Bauer Jochen
Published: August 2024

Hamburg’s “Religious Education for All” (RUfa 2.0) is a confessional multifaith approach to shared religious education and a new and unique concept in Germany and Europe. All large religious communities in Hamburg collaborate their legal responsibility for its content. RUfa 2.0 is neither grounded in neutral religious studies nor in pluralistic theology of religion but relies on differentiated learning arrangements. They enable students to learn about their own religion, to learn about other religions and to develop their religious identity through dialogue. This article outlines development, legal and organizational frameworks, goals and competences, didactical principles, teacher roles and teacher training and places them in a European perspective.
To Discipline or to Forget: A Sufi–Zen Comparative Analysis of the Self in the Writings of al-Ghazālī and Dōgen
Authors: Yazaki Saeko
Published: August 2024

Sufism and Zen share a number of theories and practices, including a concern with lived experience. This article analyses the basis of their teachings, namely, the idea of the self, in texts by two important figures in the respective traditions, Iḥyāʾ ʿulūm al-dīn (“The Revival of the Religious Sciences”) by Abū Ḥāmid al-Ghazālī (d. 505/1111) for Sufism, and Shōbōgenzō 正法眼蔵 (“The Treasury of the True Dharma-Eye”) by Dōgen 道元 (d. 1253) for Zen. Al-Ghazālī emphasises the necessity of disciplining the self (nafs) in order for the heart to remember God only, while Dōgen famously asserts the importance of learning and forgetting the self (jiko 自己) in the way of the Buddha. This study first examines al-Ghazālī’s and Dōgen’s views of the self, and then compares their teachings. The juxtaposition of the two masterpieces reveals striking similarities as well as fundamental differences at both doctrinal and practical levels. Despite these similarities, although al-Ghazālī and Dōgen have been contrasted with thinkers outside their own tradition, they have yet to be compared directly. Without denying the philosophical depth of the thought of the two authors, this study also highlights the importance of faith in both the Iḥyāʾ and Shōbōgenzō.