bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of anti-anxiety activity of Mucuna pruriens
Authors: Singh Shobhit , Gupta Pushpraj , Gupta Rishikesh
Published: September 2019

Mucuna pruriens, also known as Velvet Bean, Mucuna pruriens has been used for centuries by Ayurvedic herbalists for overall wellness. Mucuna pruriens provides support for brain function, muscle health and libido. Mucuna pruriens has also been shown to have diuretic effects. It increases tissue resiliency and improves coordination. Mucuna can also increase testosterone levels, which in turn can lead to increased muscle mass and strength. It also supports the nervous and reproductive systems in the body. anti-oxidant activity of M. pruriens has been also demonstrated in vitro by its ability to scavenge DPPH radicals and reactive oxygen species. This is an excellent natural source of L-dopa and 5-hydroxy tryptophan (5-HT) Present study was designed to evaluate the anti-anxiety activity of Mucuna pruriens extract in Swiss albino mice. Three doses of Mucuna pruriens (100, 200,400 mg/kg, p.o.) and standard dose of Buspirone (5 mg/kg, i.p.) were used for evaluation of the anti-anxiety activity. The elevated plus maze (EPM) was used to take as a measure of antianxiety effect. Mucuna pruriens at the doses of 200 mg/kg and 400 mg/kg significantly reduced the time spent and no. of entries in closed arm, increased the time spent and entries into open arm in elevated plus maze (p<0.05) as compared to control group. These results indicate that MP may be possesses antianxiety property.
Keywords:  Anxiety, Elevated plus maze, Mucuna pruriens, Buspirone, Swiss Albino Mice.
FORMULATION AND EVALUATION OF COLON TARGETED DRUG DELIVERY SYSTEM OF BUSULFAN: USING COMBINATION OF pH AND TIME DEPENDANT SYSTEMS
Authors: JAHNAVI SAI , Sharma GS , Rama B , Jyothirani ,
Published: September 2019

In present work Colon targeting drug delivery system was developed for Busulfan an anticancer drug by using combination of delayed systems one is pH dependant and other is time dependant delayed system.  Rapid release core tablet (RRCT) formulations were prepared using Busulfan drug with different disintegrating agents in different concentrations. The pre-compression and post-compression parameters of all formulations were determined and the values were found to be satisfactory. From the In-vitro dissolution studies, F6 formulation with 12% Hydroxy propyl cellulose (HPC) was the best formulation. For optimized RRCT formulation press coat was done by using Xanthum Gum and Ethyl Cellulose (EC) in different ratios. Press coated tablet delays the drug release up to 8 hours based on the nature and concentrations of the polymer. Each press coated tablet was coated using enteric solution made of HPMC phthalate, Myvacet and color dissolved in ethanol. Enteric press coated tablets (EPCT) were delayed drug release up to 2hrs in fed condition due to pH dependant delayed system.  Based on dissolution studies of EPCT formulations, C3OPF formulation was optimized and showed delayed release pattern in a much customized manner. As a result of this study it may be concluded that the colon targeted drug delivery tablets using a combination of two polymers in optimized concentrations can be used to increase the delayed action of drug release to deliver the drug in a delayed manner.
Key words: Colon, RRCT, HPC, Xanthum gum and EPCT
Evaluation of Mosquito Larvicidal Activity of Ethanolic Extract of Grewia flavescens Juss. Whole Plant (Family: Tiliaceae) Against Culex quinquefasciatus
Authors: Pramodini G.N. , Alam Parwez , Rafiq Mohd , Khasim Shaik mohd
Published: September 2019

To evaluate the mosquito larvicidal activity on the ethanolic extract of Grewia flavescens juss (EEGF). Whole plant against Culex quinquefasciatus larvae. The larval mortality of 4th instar larvae of Culex quinquefasciatus after 24h and 48h of treatment which were tested separately in control and five test concentrations of 125 ppm, 250 ppm, 500 ppm,750 ppm, 1000 ppm concentration. The plant extract was screened to identify phytochemical bioactive compounds like alkaloids, flavonoids, saponins, tannins and glycosides. Different concentration of crude ethanolic extract of Grewia flavescensjuss. whole plant effectively showed larvicidal activity on Culex quinquefasciatus larvae. Based on the probit analysis values for 24h and 48h ethanolic extract of Grewia flavescens shows pronounced larvicidal activity. The LC50 and LC90 values of EEGF against mosquito 4th instar larvae of Culex quinquefasciatus was found 223.87 ppm and 724.43 ppm at 24hrs and for 48hrs the LC50 and LC90 values was found to be 181.97ppm and 374.76 ppm respectively. The preliminary phytochemical was performed in search of plants secondary metabolites which might be responsible for the larvicidal activity. The bioactive phytochemical classes which were identified and confirmed as alkaloids, flavonoids, saponins, tannins and glycosides. The ethanolic extract of this plant showed potent larvicidal activity and can be considered for further investigation. This experimental study was a pioneer attempt to establish Grewia flavescens juss. as a valuable resource of effective target specific natural mosquito larvicide.
Keywords: Culex quinquefasciatus, larvicidal activity, ethanolic ext., phytochemical.
Citrus limon L Burmf leaves from North Eastern India : A source of Amino acids
Authors: Khatiwora Elija
Published: September 2019

Identification of amino acids from air shade dried powered material of Citrus limon L Burmf (Assam lemon) leaves was carried out in this experiment. Paper chromatographic technique was used for the qualitative determination of amino acids with different mobile phases. Specific amino acids were detected in specific mobile phases. The obtained amino acids were identified by comparing with standard amino acids. Total nine amino acids were detected from of Citrus limon L Burmf leaves. Two mobile phases were found suitable for detection of amino acids present in the leaves of citrus limon L Burmf.
Keyword: Citrus limon, Paper chromatography, Amino acids.
Formulation and Evaluation of Polyherbal Shampoo to Promote Hair Growth and Provide Antidandruff Action
Authors: Lodha Gaurav
Published: September 2019

The assurance of therapy with minimal side effects has been proven that ayurvedic formulation is to be promising for cosmetic use too. Maintenance of other factor shall not fulfill the need so extraneous treatment is essential that to which is safe. In case of hair disorder like dandruff problem, proper selection of ayurvedic ingredient with their required amounts, dosage form can be formulated as powder shampoo to fight against dandruff. A more radical approach in reducing the synthetic ingredient is by incorporating natural extract whose functionality is comparable with their synthetic ingredient. A shampoo is a cleansing aid for the hair and is counted among the foremost beuty products. Several herbs are reported to be effecting is controlling such fungi in our laboratory an antidandruff herbal shampoo –Herbello was prepared and characterized. Certain improvements, especially with respect to viscosity, conditioning ability and antidandruff activity were needed. Most effective herbs were chosen and used in different combination for preparation of shampoo in order to improve antidandruff activity. This herbal shampoo was formulated using natural ingredient like Bhringraj (Eclipta Alba), Fenugreek(methi), Azadirachta indica (neem), Acacia concinna (shikakai), Sapindus mukorossi(reetha), Ocimum santum (tulsi), Piper betle (paan), Hhibiscus rosa  sinensis (Gurhal), Camellia sinesis (green tea leaf), Citrus aurantifolia (lemon), Phyllanthus emblica (amla), Eclipta alba (Brhingaraj leaf powder), Aloe Vera (Aloe leaf Powder), Ashwagandha powder, Triphala powder Nagarmotha Powder, Brahmi Root. The formulation at laboratory scale was done and evaluated for number of parameters to ensure its safety, stability and efficacy.
Keywords: Hair Dandruff shampoo, cream shampoo, Herbal Material, Antidandruff shampoo.
Therapeutic Potential of Evolvulus alsinoides
Authors: Siraj Mantasha Binth , Khan Asim Ali , Jahangir Umar
Published: September 2019

Background: Evolvulusalsinoidesis a well-known herbal drug possessing various promising medicinal properties described by prominent ancient scholars and also numerous preclinical and clinical researches has been performed, thus attestingit’s ample of pharmacological actions. So, thorough review of classical as well as contemporary literature has been executed on Evolvulusalsinoides to validate the pharmacological actions mentioned.           .

Methods:For classical review,a comprehensive search of Unani literature is done and for latest research work on evolvulus, articles published in English language using PubMed, MEDLINE, and the Google scholar with search term including Sahnkpushpi, sankhaoli, Evolvulusalsinoides since 1991 to 2019 is done.

Results: The search includescontemporary literature, ethnomedicinal sources and 35 research articles from 1992 to 2019 which further ascertains various pharmacological actions being mentioned in Unani literature including anti-inflammatory, anti-diarrheal, anti-helminthic, anti-convulsantand nootropicproperty of herb.

Conclusion:

The pharmacological action and therapeutic application of Shankhaholi/ Shankpushpiwhich ismentioned inclassical Unani literature are in accordance with latest research. Despite of having several researches on Evolvulusalsinoides there are still numerous indications mentioned in classical literature which are yet to be explored.

 

Keywords: Evolvulusalsinoides, herb, Unani, contemporary.
Nephroprotection in Unani Medicine through Herbal Medicine & their research scope: A Review
Authors: Khatoon Rizwana , Aslam Dr. Mohammad , Chaudhary Shahid Shah
Published: September 2019

Plants are very potential & vital source for human health and also used therapeutically in the various kidney disorders due to presence of phytochemical constituents. There are numerous herbs existing that have more pharmacological activities including with nephroprotective activity. Now a days herbal drugs are verified & proved as nephroprotective agents and used for improving renal health, even reverse renal damages. The current review is targeted to explain the Unani & modern concept of kidney disorders, nephrotoxicity and the list of scientifically proved medicinal plants having nephroprotective activity medicinal plants which used in the treatment of renal disorders.

Keywords: Nephroprotection, Unani Medicine, Kidney disorders
Antioxidant Activity and total Phenolic Content of Defatted Scenedesmus quadricauda KDPSC2 Biomass Extract by Microbial Fermentation
Authors: Sarumathi V. , Dhandayuthapani Krishnan , Mazher Sultana
Published: September 2019

Microalgae biomass are considered as sustainable sources for various bioactive compounds. The objective of this study to evaluate the defatted biomass of green microalga Scenedesmus quadricauda KDPSC2 as a source for enhancement of total phenolic content (TPC) and antioxidant activity by microbial fermentation. Ultrasonic assisted hydrolysate was prepared from defatted biomass using ultrasound power density of 0.3 Wcm-2 at 10 min. Then the prepared defatted biomass hydrolysate (DBH) was used as soul medium for fermentation by five different microbial strains such as Bacillus amyloliquefaciens, B. stearothermophilus, B. subtilis, Saccharomyces cerevisiae NITTS1 and Cyberlindnera jadinii MMS7. Among these microbial strains, C. jadinii MMS7 was selected for further study because it was enhanced the TPC and antioxidant activity of DBH by fermentation. Besides, the fermentation conditions were optimized by classical method of optimization and found the pH 5.5, temperature 35 oC, agitation speed 150 rpm and 36 h as optimum physical parameters for enhancing the TPC and antioxidant activity of DBH by fermentation using C .jadinii MMS7. At these optimum conditions, 4.67 fold DPPH radical scavenging activity was obtained from DBH after fermentation. Therefore, this study demonstrates that the defatted biomass of S. quadricauda KDPSC2 could be a useful source for production of TPC by C. jadinii MMS7 fermentation.

Keywords:  Cyberlindnera jadinii, Defatted biomass, Fermentation, Hydrolysate, Scenedesmus quadricauda, Total phenolic content.
Quantitative Estimation and Validation of Chlorthlidone and Azilsartan Medoximil in Bulk and Tablet Dosage Form by using RP-HPLC
Authors: Dighe Nachiket S. , Thorat Somnath K. , Shinde Ganesh S , Dhamak Kavita V
Published: September 2019

The first reversed phase high performance liquid chromatographic method for Stability Indicating of, Azilsartan and chlorthalidone has been developed and validated to be a simple, sensitive, rapid, specific, precise, and accurate method. Chromatographic separation was achieved on Zorbax XBD-C8, 250mm × 4.6mm,5µm.Buffer pH5.5 : Methanol  (60:40) as a mobile phase at flow rate of 1 ml/min. UV detection was operated at 234 nm and injection volum was 25 μl.. The proposed method showed good linearity, accuracy, precision and was successfully applied for determination of the drugs in laboratory prepared pharmaceutical dosage forms.

Keywords: Azilsartan and chlorthalidone, RP-HPLC, Stability Indicating.
Preformulation Studies of Pralidoxime Chloride for Formulation Development of Microspheres
Authors: Sharma Shyam Bihari , Jain Suman , Ganesan K.
Published: September 2019

Microspheres are one of the novel drug delivery system which possess several applications and are made up of assorted polymers. Microspheres can be defined as solid, approximately spherical particles ranging in size from 1 to 1000 μm range in diameter having a core of drug and entirely outer layers of polymers as coating material. They are made up of polymeric, waxy or other protective materials i.e. biodegradable synthetic polymer and modified natural products such as starches, gums, proteins, fats and waxes. Preformulation is a group of studies that focus on the physicochemical properties of a new drug candidate that could affect the drug performance and the development of a dosage form. This couldprovide important information for formulation design or support the need for molecular modification. Every drug has intrinsic chemical and physical properties which has been consider before development of pharmaceutical formulation. This property provides the framework for drugs combination with pharmaceutical ingredients in the fabrication of dosage form. Objective of preformulation study is to develop the elegant, stable, effective and safe dosage form by establishing kinetic rate profile, compatibility with the other ingredients and establish Physico-chemical parameter of new drug substances. The purpose of the present study was to systematically investigate some of the important physicochemical properties of pralidoxime chloride for preparation of microspheres. The physicochemical properties such as solubility, pKa, dissolution, melting point, assay development, excipient compatibility etc. of pralidoxime chloride was carried out. Before selection of excipients, the Preformulation study of drug pralidoxime is completed for successful formulation of microspheres. The result of Preformulation studies shows good flow properties, excipient compatibility, solubility efficiency and melting point. From this study we concluded that pralidoximewith HPMC and EC can be used to formulate pralidoxime microspheres for modified release.

Keywords: Microspheres, Preformulation, Pralidoxime chloride, Physico-chemical parameter.
Analytical Method Development and Validation for the Simultaneous Estimation of Aspirin, Clopidogrel and Rosuvastatin in Pharmaceutical Dosage Form
Authors: Tiwari Pradip Kumar , Jain Amit , Dubey BK , Pandey GK , Dhakad Suresh
Published: September 2019

A new, simple, novel, accurate, precise, reliable, rapid and linear reverse phase high-performance liquid chromatography (RP-HPLC) method was developed and fully validated for simultaneous qualitative and quantitative estimation of   Rosuvastatin (ROS), Clopidogrel (CLOP) and Aspirin (ASP) in bulk and pharmaceutical dosage form as per International Conference on Harmonization (ICH) guidelines. In the present work, good chromatographic separation was achieved by isocratic method using a Hypersil BDS C18 column (250 mm ×4.6, 5 μm) and a mobile phase consisting of KH2Po4 buffer pH-6.0: acetonitrile in the ratio 60:40, at a flow rate of 1 ml/min. The effluents obtained were monitored at 242nm with the UV-visible detector. The calibration curves obtained were linear (r2=0.999) over the concentration range of 7.5-22.5μg/ml and 1-3μg/ml for CLOP, ASP and ROS respectively. A run time of 7.0 minutes for each sample made it possible to analyze more than 200 samples per day. The retention time of ASP, CLOP and ROS was found to be 3.103 min, 4,277 min and 5.707 min respectively. The high recovery values (99%-101%) indicate a satisfactory accuracy. The low percent relative standard deviation (% RSD) values in the precision study reveal that the method is precise  therefore the method can be used for routine monitoring of CLOP, ASP and ROS in industry in the assay of bulk drug and dosage form.

Keywords: RP-HPLC, Rosuvastatin, Clopidogrel, Aspirin, Method validation, ICH guidelines.
Formulation and Evaluation of Topical Polyherbal Antiacne Gels Containing Luffa Acutangula, Amaranthus Spinosus and Morus Alba
Authors: Shukla Kavita Varma , Choudhary Nishi , Pathak Rekha
Published: September 2019

Anti-acne herbal formulations are used for the treatment of acne vulgaris with the added advantage of not producing adverse effects unlike synthetic drugs. Acne is an inflammatory skin disease that occurs due to blockages in polysebase and inflammation that are caused by bacteria. Topical and systemic antibiotics are always used for treatment of acne, but the gradual resistance to antibiotics can affect the success rate of acne cure. Medicinal plants play an important role in the development of potent therapeutic agents. Plant based drugs provide outstanding contribution to modern therapeutics as a source of many valuable secondary metabolites which serves as plant defence mechanisms against predator such as microorganism, insects and herbivores which have been proved to be potentially active compounds. There is a tremendous increase in search of antimicrobial plant extracts due to the fact that the resistance offered against antibiotic by the microorganism, in short the effective life span of any antibiotic is limited. Propionibacterium acnes are common pus-forming microbes responsible for the development of various forms of acne. In the present study anti-acne gels were prepared using polymer carbopol 940 along with the hydroalcoholic extracts of plants fruits of Luffa acutangula, leaves of Amaranthus spinosus and Morus alba and evaluated for their physicochemical properties, like pH, washability, extrudability, spreadability and viscosity. The formulations (PHG1-PHG6) were tested for the anti-acne activity by well diffusion method against Propionibacterium acnes. Results showed that the gels were non-irritant, stable and possess anti-acne activity. The efficacy when tested with a standard was almost same to that of Clintop (Marketed gel). This suggests that fruits of Luffa acutangula, leaves of Amaranthus spinosus and Morus alba have potential against acne causing bacteria and hence they can be used in topical anti-acne preparations and may address the antibiotic resistance of the bacteria.

Keywords: Luffa acutangula, Amaranthus spinosus, Morus alba, Propionibacterium acnes, Acne vulgaris, Carbopol, Physicochemical properties.
Formulation Development and Evaluation of Gastroretentive Floating Tablets of Trazodone Hydrochloride Using Natural Polymer
Authors: Shukla Kavita Varma , Vishwakarma Priya , Pathak Rekha
Published: September 2019

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Equine Rabies Immunoglobulin: A Review
Authors: Shelke P.V. , Rachh Punit R.
Published: September 2019

Rabies is a major cause of human death in many developing countries. There is a worldwide shortage of human and equine rabies immune globulin. The WHO recommends combined administration of rabies vaccine and rabies immune globulin to patients after exposure. The implementation of post exposure prophylaxis by vaccination and specific immunoglobulin therapy are largely hampered by its high cost. The equine rabies immunoglobulin is less expensive than human rabies immunoglobulin, and is used for rabies post-exposure prophylaxis in developing countries.

Equine rabies immunoglobulin is a F(ab)2 with high specific activity, purity, and safety. Healthy horses are immunized with a rabies vaccine. Crude plasma is collected and immunoglobulin is converted into F(ab)2 fragments by pepsin digestion. The F(ab)2 fragments are purified using caprylic acid precipitation followed by ultrafiltration.

Keywords: Rabies, Equine rabies immunoglobulin (ERIG), Human rabies immunoglobulin (HRIG), IgG, Caprylic acid, Pepsin.
A Review on Phytochemical & Pharmacological Profile of Pergularia Daemia linn.
Authors: Chandak Raman R , Dighe Nachiket S
Published: September 2019

Many indigenous Indian medicinal plants have been found to be successfully used to manage diabetes and some of them have been tested and active principles isolated. However, search for new antidiabetic drugs for effective treatment is on. The vast majority of people on this planet still rely on their traditional material medica (medicinal plants and other materials) for their everyday health care needs. It is also a fact that one quarter of all medical prescriptions are formulations based on substances derived from plants or plant-derived synthetic analogs. The herbal drug from tribal region is selected for the study which is used for diabetes andliver diseases. Pergularia daemia (Asclepiadaceae) is a perennial herb growing widely along the road sides of India. It has been used in folk medicine for the treatment of Dibetis mellitus &liver disorders. It is widely distributed in the tropical and sub tropicalregions of the world. Various phytochemical including terpenoid, flavonoids, sterols and cardenolids have been isolated andidentified from the various parts of the plant (leaves, stems, shoots, roots, seeds and fruits whole plant). P. daemia widely used by various tribal communities in Western Ghats of India for the treatment of variety of ailments, while predominantly the roots of theplant have been used to treat liver disease and jaundice.The present review article aims towards medicinal Pharmacological potential, Bioactive remedies, Phytochemical profile and other important aspects of P. daemia.

Keywords: Ethnobotanical uses, Pergularia daemia, Pharmacological Profile, Phytochemical Profile
Hemşirelik Öğrencilerinin Kültürlerarası Duyarlılık ve Etnik Merkezcilik Düzeyleri
Authors: BİLGİÇ Şebnem , ŞAHİN İdil
Published: September 2019

Amaç: Bu araştırma hemşirelik öğrencilerinin kültürlerarası
duyarlılık ve etnik merkezcilik düzeylerini, etkileyen faktörleri belirlemek
amacıyla planlandı.

Materyal-Metot: Tanımlayıcı tipteki araştırma bir üniversitenin
hemşirelik bölümünde gerçekleştirildi. Araştırmada Kişisel Bilgi Formu,
Kültürlerarası Duyarlılık Ölçeği (KDÖ) ve Etnik Merkezcilik Ölçeği  (EMÖ) kullanıldı. Araştırma Ocak-Mart 2018
tarihlerinde araştırmaya katılmayı kabul eden 460 hemşirelik öğrencisi ile
yürütüldü.

Bulgular: Araştırmaya katılan öğrencilerin yaş ortalaması
20.56±1.62 olup, öğrencilerin %86.3’ü kadın idi. Öğrencilerin %72.4’ü
hemşireliği isteyerek seçtiğini, %51.5’i başka kültürlerle bir arada olmayı
istediğini, %54.1’i başka kültürlerde arkadaşı olduğunu belirtti. Öğrencilerin
KDÖ puan ortalaması 76.67±7.27 ve EMÖ puan ortalaması ise 55.40±6,68 idi.
Öğrencilerin cinsiyet, başka kültürlerle bir arada olmayı isteme ve başka
kültürlerden arkadaşı olma ile KDÖ ve EMÖ arasında anlamlı fark bulundu. Ayrıca
öğrencilerin KDÖ ve EMÖ puanları arasında negatif yönde anlamlı ilişki
belirlendi.

Sonuç: Öğrencilerin
kültürlerarası duyarlılık düzeylerinin ortalamanın üzerinde ve etnik
merkezcilik düzeylerinin ise ortalamanın altında olduğu saptandı. KDÖ puan
ortalaması kadın öğrencilerde, başka kültürlerle bir arada olmayı isteyen,
başka kültürlerden arkadaşı olan öğrencilerde daha yüksek idi. EMÖ puan
ortalaması ise erkek öğrencilerde, başka kültürlerle bir arada olmayı istemeyen,
başka kültürlerden arkadaşı olmayan öğrencilerde daha yüksek idi. Öğrencilerin
kültürlerarası duyarlılıkları arttıkça etnik merkezcilik düzeylerinin azaldığı
belirlendi. Sağlık ekibinin bir üyesi olacak hemşirelik öğrencilerinin henüz
öğrencilik dönemlerinde kültürler arası duyarlılık düzeylerinin desteklenmesi
önemlidir. Bu amaçla hemşirelik müfredat programına öğrencilerin kültürler
arası duyarlılıklarını geliştirecek ders içeriklerinin eklenmesi, öğrencilerin
farklı kültürel özelliklere sahip bireylerle bir araya getirilerek karşılıklı
etkileşimin arttırılması ve farklı kültürlerdeki hastalarla çalışmayı
sağlayacak projelerin planlanması önerilmektedir.
CONTRIBUIÇÕES PARA O DEBATE SOBRE AS PRÁTICAS EDUCATIVAS NAS OCUPAÇÕES DE ESCOLAS PÚBLICAS
Authors: Flach Simone de Fátima , Boutin Aldimara Catarina Delabona Brito
Published: September 2019

O artigo analisa, a partir do pensamento de Antonio Gramsci, as práticas educativas desenvolvidas durante o processo de ocupação estudantil de escolas públicas brasileiras no ano de 2016. Para tanto, apresenta reflexão sobre as limitações e as potencialidades da educação formal para a construção da hegemonia subalterna; expõe sobre a relevância dos conselhos de fábrica e do partido político como elementos que subsidiam a aquisição de conhecimentos teóricos e práticos para a intervenção na realidade e, por fim analisa algumas ações desenvolvidas durante as ocupações de 2016 e as suas contribuições para a formação da consciência coletiva. Ao final, conclui que as ocupações das escolas se caracterizaram como momentos formativos com vistas à transformação da realidade.
A HOMOLOGAÇÃO DA BASE NACIONAL COMUM CURRICULAR (BNCC) E SUAS IMPLICAÇÕES PARA A CONSTRUÇÃO DE PROPOSTAS CURRICULARES
Authors: Merli Angélica de Almeida
Published: September 2019

O artigo apresenta um estudo de cunho bibliográfico no qual são feitas reflexões acerca das implicações da homologação da Base Nacional Comum Curricular (BNCC) na (re)formulação de propostas curriculares de instituições/redes de ensino. As reflexões apresentadas são feitas a partir da articulação entre aspectos levantados durante a participação em eventos sobre a temática com o referencial teórico selecionado para o presente estudo. Dentre os aspectos apontados destacam-se: o percurso de elaboração da BNCC, a estrutura do documento, consequências da aprovação da BNCC para a (re)elaboração e implementação do currículo nas diferentes redes de ensino, demandas formativas impostas pela BNCC e desafios impostos para que o documento chegue até as escolas.Palavras-chave: BNCC. Reformulação curricular. Políticas de formação docente.
QUANDO O CAPITAL EDUCA O EDUCADOR: BNCC, NOVA ESCOLA E LEMANN
Authors: Pereira Jennifer Nascimento , Evangelista Olinda
Published: September 2019

Neste texto objetivamos interrogar um movimento importante, entre 2016 e 2018, na definição de políticas públicas para formação docente. A partir de 2008, durante o Governo Lula, do Partido dos Trabalhadores, inicia-se a trajetória de debates em torno da Base Nacional Comum Curricular do Ensino Infantil e Fundamental (BNCC). A Associação Nova Escola destacou-se nesse processo, entre outros motivos, por pertencer, a partir de 2015, à Fundação Lemann. Analisamos 86 matérias publicadas por Nova Escola, das quais três questões despontaram como centrais: formação de professores, avaliações externas em larga escala e materiais didáticos. Concluímos que Nova Escola atuou para elaborar e difundir um modelo docente estruturado sobre a apropriação das Competências Socioemocionais e o manejo das Tecnologias da Informação e Comunicação. Associando-as chegar-se-ia ao ‘professor 4.0’, preocupado com a aprendizagem pragmática, sinônimo de qualidade de ensino. Ao contrário do protagonismo docente, configura-se o professor gerenciadoPalavras-chave: Capital educador. Fundação Lemann. Nova Escola. BNCC. Professor gerenciado.
Test of Activities of Hepatoprotector of Senggani Leaf Ethanol Extract (Melastoma Malabathricum L.) ON RAT (Rattus Novergicus) That Induced by Paracetamol
Authors: Laia Yustina Yasnidar , Aulia Yoridha , Sahara Mita , Simanjuntak Masdalena Maxwel
Published: September 2019

Senggani leaves (Melastoma Malabathricum L.) are easily available plans that are sometimes used as traditional medicine. This study aimed to determine the hepatotective activity of the ethanol of senggani leaves (Melastoma Malabathricum L.) on rats (Rattus Novergicus) induced by paracetamol with histopatological parameters. Making extracts was carried out by maceration using 96% ethanol solution. The test animals used were 30 rats (Rattus Novergicus) which were divided into 6 groups. Group I without treatment, group II as negative control, group III as positive control, and group IV, V, and VI who were given senggani leaf extract, respectively 100 mg/Kg bb, 200 mg/Kg bb, and 400 mg/Kg bb for 7 day. On the 8 day all rats except group I, were induced paracetamol 180 mg/200 gr bb as the parent of liver demage. The resulst showed that the ethanol extract of senggani leaves at a dose of 400 mg/Kg bb was the most effective in hepatoprotective activity compared to a dose of 100 mg/Kg bb, and 200 mg/Kg bb with histopathological parameters induced by paracetamol.
Análise da interdisciplinaridade e transversalidade da educação ambiental no ensino médio da rede pública estadual do Rio de Janeiro: um estudo de caso.
Authors: Sacramento Patrícia , Monteiro de Barros Araujo Flávia , Roças Giselle
Published: September 2019

Nos Parâmetros Curriculares Nacionais (PCN) há um entendimento que a Educação Ambiental (EA) deva ser contemplada em todas as áreas curriculares, além de informar o discurso dos professores, permitindo que todos sejam capazes de perceber a dimensão interdisciplinar e a transversal desse tema. Nas diretrizes curriculares da Rede Pública Estadual de Ensino do Rio de Janeiro detectamos a preocupação com a discussão de questões ambientais. Entretanto, não sabemos como a EA é contemplada no currículo das escolas públicas, nem qual o envolvimento dos professores nessas possíveis ações ambientais. Nesta perspectiva, foi realizado um estudo de caso com uma escola pública de ensino médio, com o objetivo de identificar quais as percepções e vivências que os professores tem acerca do tema.
Habitual touches (carvings) of beings
Authors: eli eli
Published: September 2019

This is a story of consecvenses of concecvenses of concekvences of concecuences of consequenses of
consequences of concequenses and how i almost learned to spell this word. Its a never ending story. I
study what was before us, i draw lines and connect.
Some lines are direct, others are nonlinear and take crooked paths, where we cannot trace where it all
started.
Frequency and correlates of depression at the primary health care level in Belgrade
Authors: Vucurevic Mara , Vujovic Milena , Stojanovic-Tasic Mirijana , Maric Nadja
Published: September 2019

Introduction/Objective. The prevalence of depression in primary care is relatively high. The aim of the study was to assess the frequency of depression among patients in Zvezdara Primary Health Care Center in Belgrade. We also examined the relationship between depression and individual risk factors (sociodemographics, lifestyle characteristics, and health-related factors). Methods. A cross-sectional study, which included 422 adult patients, under 65 years of age, was conducted at the Zvezdara Primary Health Care Centre in Belgrade, Serbia, during January of 2018. The instrument used was Patient Health Questionnaire-9 (cut-off score ?10). Multivariate logistic regression analysis was applied. Results. Depression, at least of moderate intensity, was found in 36%of the respondents. Around 1.4% of the participants confirmed suicidal thoughts almost every day during the previous two weeks. The logistic regression model showed the association with depression and being married (OR: 0.24, 95% CI: 0.13?0.44), single (OR: 0.43, 95% CI: 0,22?0.83), unemployment (OR: 3.83, 95% CI: 1.51?9.76), lifetime contact with mental health services (OR: 3.79, 95% CI: 2.19?6.57), and regular treatment for chronic illnesses (OR: 3.22, 95% CI: 1.94?5.34). Conclusion. This study found a relatively high prevalence of depression among patients in the primary health care center. We found an association between depression and marital status, employment, previous contact with mental health services, and regular treatment for chronic illnesses. The Patient Health Questionnaire-9 instrument could be implemented in primary health care settings in Serbia.
Agrobacterium tumefaciens isolated from hemodialysis water
Authors: Smiesko Gordana , Gusman Vera
Published: September 2019

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Influence of Diabetes Complications on HbA1c Treatment Goals Among Older U.S. Adults: A Cost-effectiveness Analysis
Authors: Shao Hui , Lin Ji , Zhuo Xiaohui , Rolka Deborah B. , Gregg Edward W. , Zhang Ping
Published: September 2019

OBJECTIVE

Guidelines on the standard care of diabetes recommend that glycemic treatment goals for older adults consider the patient’s complications and life expectancy. In this study, we examined the influence of diabetes complications and associated life expectancies on the cost-effectiveness (CE) of HbA1c treatment goals.

RESEARCH DESIGN AND METHODS

We used data from the 2011–2016 National Health and Nutrition Examination Survey (NHANES) to generate nationally representative subgroups of older individuals with diabetes with various health states. We used the Centers for Disease Control and Prevention–RTI International diabetes CE model to estimate the long-term consequences of two treatment goals—a stringent control goal (HbA1c <7.5%) and a moderate control goal (HbA1c <8.5%)—on health and cost. Our simulation population represented typical patients, and all individuals in each health subgroup had average characteristics, which did not account for person-level variations. The CE study was conducted from a health system perspective and followed the study samples over a lifetime. We used $50,000 per quality-adjusted life year (QALY) as the incremental CE threshold.

RESULTS

A stringent goal was, on average, cost-effective for individuals with no complications ($10,007 per QALY) or only microvascular complications (excluding renal failure; $19,621 per QALY), but it was not cost-effective for individuals with one or more macrovascular complications (all >$82,413 per QALY). Further, a stringent goal was not cost-effective when an individual had less than 7 years of life remaining.

CONCLUSIONS

Our findings support the guideline recommendation that glycemic goals for older adults should consider the complexity of their complications and their life expectancy from a CE perspective.
Continuous Glucose Monitoring in People With Type 1 Diabetes on Multiple-Dose Injection Therapy: The Relationship Between Glycemic Control and Hypoglycemia
Authors: Oliver Nick , Gimenez Marga , Calhoun Peter , Cohen Nathan , Moscardo Vanessa , Hermanns Norbert , Freckmann Guido , Reddy Monika , Heinemann Lutz
Published: September 2019

OBJECTIVE

The inverse relationship between overall glucose control and hypoglycemia risk is weakened by the use of real-time continuous glucose monitoring (rtCGM). We assess the relationship between glucose control and hypoglycemia in people with type 1 diabetes using multiple-dose injection (MDI) regimens, including those at highest risk of hypoglycemia.

RESEARCH DESIGN AND METHODS

CGM data from the intervention (rtCGM) and control (self-monitored blood glucose [SMBG]) phases of the Multiple Daily Injections and Continuous Glucose Monitoring in Diabetes (DIAMOND) and HypoDE studies were analyzed. The relationship between glucose control (HbA1c and mean rtCGM glucose levels) and percentage time spent in hypoglycemia was explored for thresholds of 3.9 mmol/L (70 mg/dL) and 3.0 mmol/L (54 mg/dL), and ANOVA across the range of HbA1c and mean glucose was performed.

RESULTS

A nonlinear relationship between mean glucose and hypoglycemia was identified at baseline, with the steepest relationship seen at lower values of mean glucose. The use of rtCGM reduces the exposure to hypoglycemia at all thresholds and flattens the relationship between overall glucose and hypoglycemia, with the most marked impact at lower values of mean glucose and HbA1c. Exposure to hypoglycemia varied at all thresholds across the range of overall glucose at baseline, in the SMBG group, and with rtCGM, but the relationships were weaker in the rtCGM group.

CONCLUSIONS

Use of rtCGM can flatten and attenuate the relationship between overall glucose control and hypoglycemia, exerting its greatest impact at lower values of HbA1c and mean glucose in people with type 1 diabetes using MDI regimens and at highest risk of hypoglycemia.
ANALISIS POSTER HASIL KREATIVITAS SISWA KELAS VIII A SMP NEGERI 3 SINGARAJA DARI ASPEK BAHASA DAN ISI
Authors: Antari Ni Putu Veni , Indriani Made Sri , Artawan Gde
Published: September 2019

Permasalahan yang dibahas dalam penelitian ini yaitu: (1) Bagaimanakah aspek bahasa dalam poster hasil kreativitas siswa kelas VIII A SMP Negeri 3 Singaraja?, (2) Bagaimanakah aspek isi yang terdapat pada poster hasil kreativitas siswa kelas VIII A SMP Negeri 3 Singaraja?. Penelitian ini bertujuan untuk (1) menganalisis bahasa dalam bentuk penggunaan kalimat efektif pada poster hasil kreativitas siswa, (2) menganalisis aspek isi yang terdapat pada poster hasil kreativitas siswa. Subjek dalam penelitian ini adalah poster hasil kreativitas siswa kelas VIII A SMP Negeri 3 Singaraja . Objek dalam penelitian ini adalah bahasa dan isi poster. Metode yang digunakan dalam penelitian ini deskriptif kualitatif. Hasil penelitian menunjukkan bahwa terdapat beberapa ciri-ciri penggunaan kalimat efektif dalam poster hasil kreativitas siswa yaitu: (1) kesepadanan, (2) ketegasan, (3) kehematan. Terdapat aspek isi yang mengacu pada (1) menarik perhatian pembaca, (2) komposisi dasar, (3) kesesuaian gambar dengan pernyataan. Hasil penelitian ini menunjukkan bahwa (1) sebanyak 23 siswa yang berhasil menggunakan kalimat efektif dalam bentuk kesepadanan, 27 siswa yang berhasil menggunakan kalimat efektif dalam bentuk penekanan dan 20 siswa yang berhasil menggunakan kalimat efektif dalam bentuk kehematan. (2) Sebanyak 23 siswa yang berhasil menulis poster dikriteria menarik, 24 siswa berhasil dalam komposisi poster dan 29 siswa yang berhasil mengaitkan gambar dengan pernyataan.
Potential Effect of PISA Equivalent Questions Using the Context of Aceh Traditional Houses
Authors: Usnul Uliyatul , Johar Rahmah , Sofyan Hizir
Published: September 2019

The achievement of Indonesian students in PISA remains unsatisfactory, as evidenced by their scores that are below the baseline level set in PISA. One of the contributing factors is that Indonesian students are less trained in solving problems with characteristics such as in PISA items. Therefore, it is necessary to familiarize Indonesian students with PISA equivalent problems, but the availability of these questions is still limited, especially concerning reasoning ability. In addition, the use of context is also crucial, especially the local contexts, which can help students understand mathematical phenomena from the perspective of their life experiences. The purpose of this study was to develop the questions of PISA equivalent mathematical reasoning ability using the context of Aceh traditional houses. This research used formative evaluation type development research from Tessmer. The results of this study were 12 mathematical questions equivalent to PISA using the context of Aceh traditional house. The potential effect of the questions developed was analyzed based on the student's responses to the questionnaire, including two aspects: 1) students are interested and seriously working on the questions and 2) the students are interested in using the equivalent PISA questions in the future.
Enhancing the Conceptual, Procedural and Flexible Procedural Knowledge of Pre-Service Mathematics Teachers in Algebra
Authors: Otun Wasiu Ismaila , Olaoye Adetunji Abiola
Published: September 2019

The study investigated the effects of Solve-Reflect-Pose Strategy (SRP) on pre-service mathematics teachers’ algebraic knowledge for teaching in Nigeria. A pre-test-post-test quasi experimental design was employed. Intact classes were used and in all, 182 pre-service mathematics teachers’ participated in the study (92 in the experimental group taught with the SRP and 90 in the control group taught using the Modified Conventional Method (MCM). One research instrument manipulated at three levels namely: Conceptual Knowledge Test (CKT), Procedural Knowledge Test (PKT) and Flexible Procedural Knowledge Test (FPKT), was used for the quantitative data and interview protocol for qualitative data. The two research questions formulated were analysed using descriptive statistics while independent sample t-test was used to analyse the two hypotheses. Results showed that there were statistically significant differences in the mean post-test achievement scores on conceptual knowledge test, procedural knowledge test and flexible procedural knowledge test between pre-service teachers exposed to the SRP and those exposed to the MCM, all in favour of the SRP group. Based on the results, SRP should be adopted as an instructional strategy and efforts should be made to integrate the philosophy of SRP into the pre-service teachers’ curriculum at the teacher-preparation institutions.
Improving Students’ Productive Disposition through Realistic Mathematics Education with Outdoor Approach
Authors: Haji Saleh , Yumiati Yumiati , Zamzaili Zamzaili
Published: September 2019

This study aimed to improve the students’ productive disposition (PD) through Realistic Mathematics Education (RME) learning with an outdoor approach based on school level. Productive disposition development is intended so that students can appreciate mathematics as a science needed for their lives. The method used in this research was a quasi-experimental study. The population was 210 students of the fifth grade of Elementary School from five schools. The sample was 75 fifth grade students. The data were collected by using a questionnaire. Data were analyzed using t-test to find out the difference between the experimental and the control group. The results of this study indicate that RME learning with the outdoor approach more influential than the conventional learning in improving PD in high school level. Otherwise, in medium and low level school, the conventional learning was more influential than the RME learning with the outdoor approach to improve the students’ PD. Therefore, it can be concluded that the school level needs to be considered in improving students’ productive disposition through RME learning with an outdoor approach. Moreover, RME learning with an outdoor approach as an alternative model to improve productive disposition of students.
Front Matter (Cover, Editorial Board, Indexing and Abstracting, Table of Content)
Authors: Board Editorial
Published: September 2019

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The impact of electronic devices on the physical growth and development of modern youth and recommendations on their safe use
Authors: Milushkina O.Yu. , Skoblina N.A. , Markelova S.V. , Tatarinchik A.A. , Melikhova E.P. , Libina I.I. , Popov M.V.
Published: September 2019

The impact of excessive exposure to electronic devices (ED) on youth health remains understudied. There is a pressing need to develop recommendations for the safe use of stationary and mobile ED aimed at minimizing health risks. In this work, we assess the effect of ED on the physical growth and development of high-school and university students and provide recommendations for preventing the negative impact of prolonged screen time on health. The study recruited 460 high-school and 598 university students. Standard anthropometric measurements were taken. The psychological and emotional state of the participants was evaluated using the Test Anxiety Inventory by Spielberg (modified by Khanin). To estimate daily and weekly exposure to ED the participants were asked to fill out standardized questionnaires. In high school students, the average screen time was 7 h a day; in university students, 8.5 to 10 h a day. Only 60% of the participants, regardless of their place of residence or the type of educational institution they were attending, were physically healthy. We conclude that prolonged and frequent exposure to ED is one of the factors that can interfere with normal physical growth and development in youth. Regular daily use of stationary ED increases the risk of developing body weight deficit by 24% and gaining excess body weight by 10%. We recommend that students should eliminate computers, laptops and stationary ED from their daily activities for at least one day at the weekend and reduce total screen time to 3 hours a day.
Synchrotron IR-microspectroscopy-based visualization of molecular and chemical interactions between dental cement, biomimetic composite and native dental tissue
Authors: Goloshchapov DL , Kashkarov V.M. , Ippolitov Yu.A. , Ippolitov I.Yu. , Vongsvivut Jitraporn , Seredin P.V.
Published: September 2019

The low affinity of composite materials for the hard tissue of human teeth poses a challenge to restorative dentists. This study was undertaken to explore molecular and chemical characteristics of the interface between the dental cement, the buffer layer formed from a next generation biomimetic material that mimics the organic mineral composition of human enamel and dentin, and the intact native hard dental tissue. Seven plane-parallel dental slices were analyzed using synchrotron IR microspectroscopy. The obtained absorption spectra of functional molecular groups were organized into cluster maps. This allowed us to identify the intact tissue, the adhesive agent and the biomimetic layer at their interface and to localize and measure concentrations of functional groups involved in the integration of the biomimetic composite into the hard tissue of the human tooth. The proposed biomimetic material is based on nanocrystal carbonate-substituted calcium hydroxyapatite synthesized from a biogenic calcium source and a complex of basic polar amino acids copying the composition of the human tooth and can form a functional bond with hard dental tissue.
Application of culture-based, mass spectrometry and molecular methods to the study of gut microbiota in children
Authors: Efimov B.A. , Chaplin A.V. , Sokolova S.R. , Chernaia Z.A. , Pikina A.P. , Savilova A.M. , Kafarskaya L.I.
Published: September 2019

In recent decades, nucleic acid sequencing technologies used for metagenomic analysis have become the main methods for assessing the composition of microbiota. At the same time, the use of novel methods of cultivation and identification of microorganisms in microbiological research led to the renaissance of culture-based technologies, because facilitated the discovery and isolation of both new strains of well-known microorganisms as well as uncultivated and unexplored bacterial taxa. The aim of this study was to evaluate the potential of using the culture-based method for the assessment of the qualitative and quantitative composition of the intestinal microbiota in healthy children. Eleven growth media were inoculated with serial dilutions of stool samples in order to analyze the profile of dominant anaerobic bacteria, as well as aerobic bacteria and fungi in 20 healthy children aged 2–4 years. The identification of microorganisms was performed using MALDI TOF MS and 16S rRNA gene fragment sequencing were used. 1,819 isolated and identified strains belong to 7 phyla, 13 classes, 18 orders, 33 families, 77 genera and 149 species in the Bacteria domain. The Bacteroidetes, Firmicutes, Actinobacteria and Proteobacteria phyla were most abundant and frequent. The greatest species diversity (more than 85 species) was found in the Firmicutes phylum. Ten new previously uncharacterized bacterial strains were isolated.