bluuebunny/crossref_metadata_2025 huggingface dataset:
Knockdown of 60S ribosomal protein L14-2 reveals their potential regulatory roles to enhance drought and salt tolerance in cotton
Authors: SHIRAKU Margaret Linyerera , MAGWANGA Richard Odongo , CAI Xiaoyan , KIRUNGU Joy Nyangasi , XU Yanchao , MEHARI Teame Gereziher , HOU Yuqing , WANG Yuhong , WANG Kunbo , PENG Renhai , ZHOU Zhongli , LIU Fang
Published: October 2021

Background

Cotton is a valuable economic crop and the main significant source of natural fiber for textile industries globally. The effects of drought and salt stress pose a challenge to strong fiber and large-scale production due to the ever-changing climatic conditions. However, plants have evolved a number of survival strategies, among them is the induction of various stress-responsive genes such as the ribosomal protein large (RPL) gene. The RPL gene families encode critical proteins, which alleviate the effects of drought and salt stress in plants. In this study, comprehensive and functional analysis of the cotton RPL genes was carried out under drought and salt stresses.

Results

Based on the genome-wide evaluation, 26, 8, and 5 proteins containing the RPL14B domain were identified in Gossypium hirsutum, G. raimondii, and G. arboreum, respectively. Furthermore, through bioinformatics analysis, key cis-regulatory elements related to RPL14B genes were discovered. The Myb binding sites (MBS), abscisic acid-responsive element (ABRE), CAAT-box, TATA box, TGACG-motif, and CGTCA-motif responsive to methyl jasmonate, as well as the TCA-motif responsive to salicylic acid, were identified. Expression analysis revealed a key gene, Gh_D01G0234 (RPL14B), with significantly higher induction levels was further evaluated through a reverse genetic approach. The knockdown of Gh_D01G0234 (RPL14B) significantly affected the performance of cotton seedlings under drought/salt stress conditions, as evidenced by a substantial reduction in various morphological and physiological traits. Moreover, the level of the antioxidant enzyme was significantly reduced in VIGS-plants, while oxidant enzyme levels increased significantly, as demonstrated by the higher malondialdehyde concentration level.

Conclusion

The results revealed the potential role of the RPL14B gene in promoting the induction of antioxidant enzymes, which are key in oxidizing the various oxidants. The key pathways need to be investigated and even as we exploit these genes in the developing of more stress-resilient cotton germplasms.
Assessment of conventional and air-jet wheel deflectors for drag reduction of the DrivAer model
Authors: Nabutola Kaloki L. , Boetcher Sandra K. S.
Published: October 2021

Aerodynamic drag is a large resistance force to vehicle motion, particularly at highway speeds. Conventional wheel deflectors were designed to reduce the wheel drag and, consequently, the overall vehicle drag; however, they may actually be detrimental to vehicle aerodynamics in modern designs. In the present study, computational fluid dynamics simulations were conducted on the notchback DrivAer model—a simplified, yet realistic, open-source vehicle model that incorporates features of a modern passenger vehicle. Conventional and air-jet wheel deflectors upstream of the front wheels were introduced to assess the effect of underbody-flow deflection on the vehicle drag. Conventional wheel-deflector designs with varying heights were observed and compared to 45∘ and 90∘ air-jet wheel deflectors. The conventional wheel deflectors reduced wheel drag but resulted in an overall drag increase of up to 10%. For the cases studied, the 90∘ air jet did not reduce the overall drag compared to the baseline case; the 45∘ air jet presented drag benefits of up to 1.5% at 35 m/s and above. Compared to conventional wheel deflectors, air-jet wheel deflectors have the potential to reduce vehicle drag to a greater extent and present the benefit of being turned off at lower speeds when flow deflection is undesirable, thus improving efficiency and reducing emissions.
Spectrum of clinical manifestation of methylmalonic acidemia and homocystinuria in a family of six siblings: novel combination of transcobalamin receptor defect (CD320) and cblC deficiency (MMACHC)
Authors: Waheed Nadia , Fayyaz Zafar , Imran Ahmad
Published: October 2021

Background

Methylmalonic acidemia with homocystinuria is caused by a rare inborn error of vitamin B12 (cobalamin) metabolism. There are four complementation classes of cobalamin defects cblC, cblD, cblF, and cblJ that are responsible for combined methylmalonic acidemia and homocystinuria.

Case presentation

We report a case of a Pakistani family composed of six children diagnosed with methylmalonic acidemia and homocystinuria (MMA + HCU). Mutation analysis of siblings revealed a variable combination of c.394C>T mutation in the MMACHC gene and c.262_264del in CD320 gene. All siblings had variable age of onset, initial symptomatology, the severity of disease, and response to treatment. The maximum age of presentation was 6.5 years and the minimum age was at birth. The spectrum of symptoms ranged from a subtle learning disability to global developmental delay within the same family. None of them had a seizure disorder, megaloblastic anemia, visual disturbance, and vascular events.CD320 defect itself is very rare, and only 12 cases have been reported so far. We report six cases, four of them had homozygous MMACHC variant c.394C>T and the other two had heterozygous MMACHC mutations in c.394C>T and c.262_264del in CD 320 genes. To date, neither such case has been reported in the literature or this compound heterozygous mutation.

Conclusion

Our case report emphasizes that the diagnosis of inherited metabolic disorder in a child obviates the need to screen all siblings for the same disorder.
Characterization of a carbonate geothermal reservoir using rock-physics-guided deep neural networks
Authors: Allo Fabien , Coulon Jean-Philippe , Formento Jean-Luc , Reboul Romain , Capar Laure , Darnet Mathieu , Issautier Benoit , Marc Stephane , Stopin Alexandre
Published: October 2021

Deep neural networks (DNNs) have the potential to streamline the integration of seismic data for reservoir characterization by providing estimates of rock properties that are directly interpretable by geologists and reservoir engineers instead of elastic attributes like most standard seismic inversion methods. However, they have yet to be applied widely in the energy industry because training DNNs requires a large amount of labeled data that is rarely available. Training set augmentation, routinely used in other scientific fields such as image recognition, can address this issue and open the door to DNNs for geophysical applications. Although this approach has been explored in the past, creating realistic synthetic well and seismic data representative of the variable geology of a reservoir remains challenging. Recently introduced theory-guided techniques can help achieve this goal. A key step in these hybrid techniques is the use of theoretical rock-physics models to derive elastic pseudologs from variations of existing petrophysical logs. Rock-physics theories are already commonly relied on to generalize and extrapolate the relationship between rock and elastic properties. Therefore, they are a useful tool to generate a large catalog of alternative pseudologs representing realistic geologic variations away from the existing well locations. While not directly driven by rock physics, neural networks trained on such synthetic catalogs extract the intrinsic rock-physics relationships and are therefore capable of directly estimating rock properties from seismic amplitudes. Neural networks trained on purely synthetic data are applied to a set of 2D poststack seismic lines to characterize a geothermal reservoir located in the Dogger Formation northeast of Paris, France. The goal of the study is to determine the extent of porous and permeable layers encountered at existing geothermal wells and ultimately guide the location and design of future geothermal wells in the area.
Conference Preview: 2021 Summit on Drone Geophysics set for 2 to 5 November
Authors: Sander-Olhoeft Morgan , Quigley Laura , Whitesell Laurie
Published: October 2021

Postconvention workshops focused on drones, unmanned airborne systems (UASs), and unmanned aerial vehicles (UAVs) have occurred previously at the SEG Annual Meeting. In 2017, the SEG Near-Surface Geophysics Technical Section conducted the first such event called Drones Applied to Geophysical Mapping. This first event ushered in the topic for future Annual Meetings. In 2018, the postconvention event was called Advances in Unmanned Airborne Systems Geophysics. Both events were hugely successful and helped set the stage for the standalone reoccurring virtual Summit on Drone Geophysics.
Effects of COVID-19-related life changes on mental health in Syrian refugees in Turkey
Authors: Bernardi Luca , Gotlib Ian H. , Zihnioğlu Özge
Published: October 2021

Background

Mental disorders are currently the greatest global health burden. The coronavirus diseases 2019 (COVID-19) pandemic is having an adverse impact on people's mental health, particularly in vulnerable populations, such as refugees.

Aims

The present study was designed to examine the association between COVID-19 and changes in mental health in Syrian refugees in Turkey.

Method

We conducted a two-wave panel survey of a representative sample of 302 of the estimated 500 000 Syrian refugees (ages 18 and older) living under humanitarian support in Istanbul (first wave between 9 and 15 July 2020 and the follow-up between 11 and 14 September 2020). We administered seven items from the CoRonavIruS Health Impact Survey in addition to one-context specific item about life changes because of COVID-19, and measures of depression (10-item Center for Epidemiologic Study Depression Scale, CESD-10), anxiety (6-item State-Trait Anxiety Inventory, STAI-6) and perceived stress (Perceived Stress Scale, PSS-4).

Results

A factor analysis yielded three COVID-19 factors, labelled ‘social relationships’, ‘stress’ and ‘hope.’ We conducted a series of cross-lag panel analyses to test associations between the COVID-19 factors and mental health. We found associations between all COVID-19 factors and CESD-10, between COVID-19 ‘stress’ and STAI-6, and between COVID-19 ‘stress’ and COVID-19 ‘hope’ and PSS-4.

Conclusions

Our measures of life changes because of the COVID-19 pandemic are associated with changes in the mental health of Syrian refugees living in Istanbul. It is therefore important that they are provided with services to reduce what may be particularly debilitating consequences of COVID-19.
Early Detection of Prolonged Decreases in Maximal Voluntary Contraction Force after Eccentric Exercise of the Knee Extensors
Authors: RUAS CASSIO V. , LATELLA CHRISTOPHER , TAYLOR JANET L. , HAFF G. GREGORY , NOSAKA KAZUNORI
Published: October 2021

Purpose

We examined whether the magnitude of muscle damage indicated by changes in maximal voluntary isometric contraction (MVIC) strength 1 to 3 d after unaccustomed eccentric exercise (ECC) was correlated with changes in central and peripheral neuromuscular parameters immediately post-ECC.

Methods

Twenty participants (19–36 yr) performed six sets of eight eccentric contractions of the knee extensors. Rate of force development (RFD) during knee extensor MVIC, twitch force, rate of force development (RFDRT) and rate of relaxation (RRRT) of the resting twitch, maximal M-wave (MMAX), voluntary activation, silent period duration, motor-evoked potentials (MEP) and short-interval intracortical inhibition were assessed before, immediately after, and 1 to 3 d post-ECC. Relationships between changes in these variables immediately post-ECC and changes in MVIC strength at 1 to 3 d post-ECC were examined by Pearson product–moment (r) or Spearman correlations.

Results

Maximal voluntary isometric contraction strength decreased (−22.2% ± 18.4%) immediately postexercise, and remained below baseline at 1 (−16.3% ± 15.2%), 2 (−14.7% ± 13.2%) and 3 d post-ECC (−8.6% ± 15.7%). Immediately post-ECC, RFD (0–30-ms: −38.3% ± 31.4%), twitch force (−45.9% ± 22.4%), RFDRT (−32.5% ± 40.7%), RRRT (−38.0% ± 39.7%), voluntary activation (−21.4% ± 16.5%) and MEP/MMAX at rest (−42.5% ± 23.3%) also decreased, whereas the silent period duration at 10%-MVIC increased by 26.0% ± 12.2% (P < 0.05). Decreases in RFD at 0 to 30 ms, 0 to 50 ms, and 0 to 100 ms immediately post-ECC were correlated (P < 0.05) with changes in MVIC strength at 1 d (r = 0.56–0.60) and 2 d post-ECC (r = 0.53–0.63). Changes in MEP/MMAX at 10%-MVIC immediately post-ECC were correlated with changes in MVIC strength at 1 d (r = −0.53) and 2 d (r = −0.54) post-ECC (P < 0.05).

Conclusions

The magnitude of decrease in MVIC strength at 1 to 3 d after ECC was associated with the magnitude of changes in RFD and MEP/MMAX immediately post-ECC. However, based on individual data, these markers were not sensitive for the practical detection of muscle damage.
Effects of Nitrogenous Fertilization and some Insecticides on the Natural Enemies of Transgenic Bt Cotton Pests
Authors: Fadlelmawla Mamoun , Abdelbagi Azhari , Ishag Abd Elaziz , Hammad Ahmed , Hur Jang-Hyun
Published: October 2021

Field assessment of integrated management of BT cotton pests was carried out in two consecutive seasons; 2016/2017 and 2017/2018 in the experimental research farm of the Kassala University, Sudan. Four insecticides (imidacloprid, abamectin, profenofos, and lufenuron) from different chemical groups and with a different mode of action and three levels (43.81 kgha-1, 87.62 kgha-1, and 131.43 kgha-1) of soil-applied nitrogen were tested in the IPM package. Insecticides were applied at the recommended doses. A total of 7 weekly counts of prevailing natural enemies [Chrysoperla carnea (Stephens) and Aenasius bambawalei Hayat] were carried out for 4 weeks before spraying and 3 weeks post spraying starting the 3rd week from spraying. Results indicated that nitrogen level exerted no significant effects on the populations of prevailing natural enemies; C. carnea and A. bambawalei. Based on average post spray counts and percentage reduction over the control, all insecticide treatments significantly reduced the population of the natural enemies. Imidacloprid and profenofos exerted the highest reduction of C. carnea population followed by abamectin and lufenuron (56.03, 48.25, 07.78 and 06.61% respectively) in the first season, while profenofos, imidacloprid, lufenuron, and abamectin induced the highest reductions (55.94, 45.05, 17.57 and 17.33% respectively) in the second season. On the other hand, reductions in A. bambawalei population (abundant in season 1 only) followed the order; imidacloprid, lufenuron, abmectin, and profenofos (03.95, 02.63, 202.63, and 01.32%, respectively). Interactions between nitrogen fertilization and insecticide were not significant as measured by the population of prevailing natural enemies.
2019 Foundation for Polish Science Prizes delivered
Authors: Wojtysiak-Łańska Dominika
Published: October 2021

.
Usefulness of Color Doppler Ultrasonography for the Preoperative Evaluation of Thin Anterolateral Thigh Flap Perforators
Authors: Lee Kyung Jin , Park Ilou , Roh Si Young , Koh Sung Hoon , Kim Jin Soo , Lee Dong Chul , Koo Jin Hoi
Published: October 2021

Purpose: The anterolateral thigh flap is commonly applied to various body sites for reconstruction. However, surgeons often struggle against unexpected locations and the nature of perforator vessels during surgery. Thus, this study aimed to assess the accuracy and usefulness of color Doppler ultrasonography as a preoperative tool for the perforator position and course of anterolateral thigh flaps.Methods: A prospective study involving 77 anterolateral thigh flaps was conducted between March 2016 and February 2021. Among them, 37 perforators (group A) were detected using the preoperative color Doppler ultrasound, and the other 40 perforators (group B) were tested using a hand-held Doppler only. All patients in group A underwent color Doppler ultrasonography performed by a radiologist at our institution. The nature and course of the perforator vessels were recorded, and their precise locations were plotted in an orthonormal coordinate system.Results: A total of 37 anterolateral thigh perforator flaps (group A) were successfully dissected. The median distance between the preoperative color Doppler ultrasonography and the real location during surgery of the perforators was 7.50 mm, which was statistically smaller than 10 mm (p<0.001). This preoperative ultrasound test also had a success rate of 94.6% to determine the nature of the perforators (musculocutaneous type vs. septocutaneous type).Conclusion: Preoperative color Doppler ultrasonography provides a harmless, reliable, and accurate technique for visualizing the vascular anatomy of anterolateral thigh flaps. It has a high correlation with surgical findings, allowing surgeons to cope with variable vascular anatomy.
Comparison of Results Based on the Number of Kirschner Wires of Different Diameters in Antegrade Intramedullary Fixation of Fifth Metacarpal Neck Fractures
Authors: Lee Dong Chul , Park Jung Hyun , Koh Sung Hoon , Kim Jin Soo , Lee Kyung Jin , Roh Si Young
Published: October 2021

Purpose: The purpose of this study was to compare the clinical and radiological results of patients with fifth metacarpal neck fractures using different sizes and numbers of Kirschner wires (K-wire).Methods: A single institutional retrospective review identified 67 patients with a fifth metacarpal neck fracture between January 2015 and July 2020. The minimum follow-up time was 6 months and they were all treated within 6.4 days of the initial injury. Either one K-wire (1.6 mm), two K-wires (1.1 mm), or three K-wires (0.9 mm) was used. We analyzed the bone union period, and K-wire removal period, duration of surgery, total active motion, intramedullary diameter, pre/postoperative shortening, and pre/postoperative angulation clinically. We used a Method of Shortening Stipulated to measure shortening and the Medullary Canal-lateral view method for angulation. The intramedullary diameter was measured in the mid-shaft of the fifth metacarpal bone in the coronal view. Total active motion was measured at the time of follow-up in our outpatient department.Results: Clinical and radiological parameters showed no statistically significant differences. Even though it did not present a statistical significance, the absolute mean duration of surgery was the shortest in a single K-wire group. Conclusion: The clinical and radiological outcomes of surgery were comparable regardless of the number of K-wires inserted. However, we could look forward to gaining potential benefit from shortened operation time in a single K-wire group. Since stable fixation can be obtained even if one K-wire is used, inserting one thick K-wire into the intramedullary canal can be an alternative according to the surgeon’s preference.
Osteoarthritis after Extension Block Technique for the Bony Mallet Finger
Authors: Koh Sung Hoon , Park Jung Hyun , Kim Jin Soo , Roh Si Young , Lee Kyung Jin , Lee Dong Chul
Published: October 2021

Purpose: The purpose of this study is to investigate osteoarthritis after treatment of bony mallet finger using the extension block method.Methods: A single institutional retrospective review identified 163 patients with bony mallet between January 2012 and July 2020 and received surgical treatment using extension block method. The radiographic examination showed that the fracture line disappeared and a bridging callus was formed and bone union was confirmed. Fractures were classified according to the Tubiana classification method. Demographic data, fracture pattern, postoperative X-ray, and late complications were analyzed. Clinical outcomes were analyzed using Crawford’s criteria.Results: Surgical treatment was performed within an average of 8.8 days after injury, and the average follow-up period was 11.6 weeks. Osteoarthritis findings were confirmed by joint space narrowing and osteophytes on radiographic examination of 32 out of 163 patients. Age, sex, occupation, location of trauma, operation time, and type of fracture did not affect the osteoarthritis after extension block. Invasion of Kirschner wire (K-wire) to the fracture surface, family history of osteoarthritis, and operation time turned out to have a statistically significant effect on osteoarthritis (p<0.05).Conclusions: Fracture surface invasion of K-wire and family history of osteoarthritis affect osteoarthritis after treatment of bony mallet.
PENGARUH WORKPLACE BULLYING DAN PERCEIVED SUPERVISOR SUPPORT TERHADAP TURNOVER INTENTION
Authors: Merdiana Candra Vionela , Gumelar Bagus
Published: October 2021

This study aims to analyze the effect of Workplace Bullying and Perceived Supervisor Support on Turnover Intention of Employees of a Private University in Yogyakarta.. This research is a quantitative research through a survey method using a questionnaire. The sample in this study were some employees of a Private University in Yogyakarta with a total sample of 71 employees. The sampling technique in this study is non-probability sampling with the Incidental Sampling method. The unit of analysis used in this study is the individual, namely the employee of a Private University in Yogyakarta. This study uses an instrument test conducted with validity and reliability tests as a condition before testing the hypothesis, while the multiple regression analysis method is used to test the hypothesis. The results of hypothesis testing using multiple regression analysis indicate that the first hypothesis is accepted, namely the effect of work bullying has a positive and significant effect on turnover intentions, the second hypothesis is rejected, namely the influence of supervisor support perceptions has no significant effect on turnover intention.
PENGARUH INVESTMENT OPPORTUNITY SET, CORPORATE SOCIAL RESPONSIBILITY, DAN RISIKO BISNIS TERHADAP NILAI PERUSAHAAN
Authors: Alamsyah Muhammad Fuad , Malanua Widyawati
Published: October 2021

This study aims to determine the effect of investment opportunity set, corporate social responsibility and business risk on firm value. Investment opportunity set is measured using market book value equity, capital expenditure to book value of assets and corporate social responsibility is measured by corporate social responsibility disclosure index and business risk is measured by business risk in banking sub-sector companies listed on the Indonesia Stock Exchange (IDX) in 2015-2019. the method of determining the sample using purposive sampling then obtained a sample of 39 companies. The data analysis technique used is multiple regression analysis. The results showed that the investment opportunity set consisting of market book value equity had a significant effect on firm value, capital expenditure to book value of assets had no significant effect on firm value, corporate social responsibility had a significant effect on firm value, and business risk had no effect on firm value.
EFEK LINGKUNGAN KERJA DAN EFIKASI DIRI PADA KINERJA KARYAWAN
Authors: Sofiatun Ulfa , Mansyur Anwar
Published: October 2021

This study aims to examine the effect of work environment and self-efficacy on employee performance. The object of this research is a historical and tourism site in the Semarang City, namely the Sam Poo Kong Temple and Lawang Sewu. The research was conducted in quantitative method by distributing questionnaire to the employee in the both locations. The sampling method that purposive sampling technique with the criteria of respondents are employee has been working for at least one year. Based on the data collection, a sample of 107 employees was obtained to be analyzed. The data were analyzed using regression analysis method. The results of the study strengthen the findings of previous studies that work environment and self-efficacy have a positive effect on employee performance.
BIAYA AGENSI DAN POTENSI KEBANKRUTAN BANK UMUM KEGIATAN USAHA 1 DAN 2 DI INDONESIA
Authors: Solihudin Ahmad Rizal , Pratiwi Permata Dian
Published: October 2021

The Bank’s risk of bankruptcy has risen due to the pandemic's impact on financial distress. This study aims to evaluate the effectiveness of risk control mechanisms on the banking sector listed in the Indonesia Stock Exchange (IDX). Agency cost which could indicate the ability to reduce the risk of bank bankruptcy was proxied by commissioner fee, insider ownership, and audit committee and then assigned as the variables of the study. This study employed quantitative methods, by using panel data regression analysis. Bank Umum Kegiatan Usaha 1 (BUKU 1) and Bank Umum Kegiatan Usaha 2 (BUKU 2) were used as samples for this study. The results show that commissions and insider ownership have no significant impact on financial distress at BUKU 1 and BUKU 2. While the Audit Committee has a significant impact on the value of financial distress at BUKU 1 and BUKU 2. In The perspective of the X-Score model, agency costs have no significant effect on the likelihood of bankruptcy at BUKU 1 and BUKU 2.
Fabrication and characterisation of a wound dressing composed of polyvinyl alcohol and quince seed mucilage
Authors: Jafari Mahshid , Baniasadi Hossein , Rezvanpour Alireza , Lotfi Marzieh
Published: October 2021

Objective:

Providing a suitable environment to improve the healing process is the main target of wound dressing that also protects the wound from additional harms. In the present study, fabrication and characterisation of a new kind of electrospun wound dressing composed of polyvinyl alcohol (PVA) and quince seed mucilage (QSM) is reported.

Method:

QSM was extracted from quince seeds, purified, freeze-dried and used to produce aqueous solutions containing different amounts of PVA and QSM. The wound dressings were fabricated via the electrospinning method and their characteristics were investigated with scanning electron microscope (SEM) images, Fourier transform infrared (FTIR) spectra, tensile and swelling test, and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) cytotoxicity assay against fibroblast cells.

Results:

SEM images confirmed that proper, uniform, non-oriented nanofibres with an average diameter in the range of 60–240nm, depending on the QSM content had been fabricated. The tensile test showed that with increasing QSM content, the tensile strength of fibre increased while elongation at break was decreased, which was consistent with SEM images where the diameter of samples decreased by increasing QSM content. MTT assay showed significant biocompatibility against fibroblast cells; however, it was increased by increased QSM proportion. In addition, SEM images supported the proper adhesion of fibroblast cells on the sample one day after culturing.

Conclusion:

Overall, the findings of the current study support the potential of PVA/QSM nanofibres as a proper candidate for biomedical applications, especially as a wound dressing.
The effects of kiwifruit dressing on hypertrophic scars in a rabbit ear model
Authors: Mousavizadeh Seyed Mehdi , Torbati Peyman Mohammadi , Daryani Amir
Published: October 2021

Aims:

Hypertrophic scars show abnormal responses during healing. These scars, associated with dysregulated growth and excessive collagen formation, can have both functional and cosmetic consequences for patients. The present study evaluated the effects of kiwifruit on hypertrophic scars in a rabbit ear model.

Methods:

This study included 13 New Zealand albino rabbits with full thickness wounds down to the cartilage (four wounds per ear; total: 104 scars). Sixteen days after initial wound formation, one ear of each rabbit was treated with daily kiwifruit dressing, while the other ear (control group) was dressed after normal saline irrigation for 10 days. Harvested skin samples were examined for histopathological, morphometric and immunohistochemical results.

Results:

In comparison with the control group, early kiwifruit dressing significantly reduced the scar elevation index, fibroblast count and dermal collagen organisation. The ratio of collagen type III to total collagen immunoreactivity, inflammation and dermal capillary count increased significantly in the treated group, compared to the untreated controls.

Conclusion:

Based on the findings, early kiwifruit dressing improved the histological features of cutaneous wounds in rabbits. Therefore, this approach may be effective in clinical practice.
Modular component exchange and outcome of DAIR for hip and knee periprosthetic joint infection
Authors: Gerritsen Maxime , Khawar Abdullah , Scheper Henk , van der Wal Robert , Schoones Jan , de Boer Mark , Nelissen Rob , Pijls Bart
Published: October 2021

Aims

The aim of this meta-analysis is to assess the association between exchange of modular parts in debridement, antibiotics, and implant retention (DAIR) procedure and outcomes for hip and knee periprosthetic joint infection (PJI).

Methods

We conducted a systematic search on PubMed, Embase, Web of Science, and Cochrane library from inception until May 2021. Random effects meta-analyses and meta-regression was used to estimate, on a study level, the success rate of DAIR related to component exchange. Risk of bias was appraised using the (AQUILA) checklist.

Results

We included 65 studies comprising 6,630 patients. The pooled overall success after DAIR for PJI was 67% (95% confidence interval (CI) 63% to 70%). This was 70% (95% CI 65% to 75%) for DAIR for hip PJI and 63% (95% CI 58% to 69%) for knee PJI. In studies before 2004 (n = 27), our meta-regression analysis showed a 3.5% increase in success rates for each 10% increase in component exchange in DAIR for hip PJI and a 3.1% increase for each 10% increase in component exchange for knee PJI. When restricted to studies after 2004 (n = 37), this association changed: for DAIR for hip PJI a decrease in successful outcome by 0.5% for each 10% increase in component exchange and for DAIR for knee PJI this was a 0.01% increase in successful outcome for each 10% increase in component exchange.

Conclusion

This systematic review and meta-regression found no benefit of modular component exchange on reduction of PJI failure. This limited effect should be weighed against the risks for the patient and cost on a case-by-case basis. The association between exchange of modular components and outcome changed before and after 2004. This suggests the effect seen after 2004 may reflect a more rigorous, evidence-based, approach to the infected implant compared to the years before. Level of Evidence: Level III Cite this article: Bone Jt Open 2021;2(10):806–812.
October 2021 Critical Care Case of the Month: Unexpected Post-Operative Shock
Authors:   University of Arizona, Tucson, AZ USA, Srinivasan Sharanyah , Kumar Sooraj , Jarrett Benjamin , Campion Janet
Published: October 2021

No abstract available. Article truncated after 150 words. History of Present Illness: A 55-year-old man with a past medical history significant for endocarditis secondary to intravenous drug use, osteomyelitis of the right lower extremity was admitted for ankle debridement. Pre-operative assessment revealed no acute illness complaints and no significant findings on physical examination except for the ongoing right lower extremity wound. He did well during the approximate one-hour “incision and drainage of the right lower extremity wound”, but became severely hypotensive just after the removal of the tourniquet placed on his right lower extremity. Soon thereafter he experienced pulseless electrical activity (PEA) cardiac arrest and was intubated with return of spontaneous circulation being achieved rapidly after the addition of vasopressors. He remained intubated and on pressors when transferred to the intensive care unit for further management. PMH, PSH, SH, and FH: • S/P Right lower extremity incision and drainage for suspected osteomyelitis as above • Distant history of endocarditis related …
Imagine there’s no university: sustaining academic identifications in pandemic times
Authors: Sánchez Gustavo
Published: October 2021

Through an autoethnographic exercise, this article reflects on the destabilisations that the Covid-19 pandemic has provoked for academic identifications. Drawing from Lacanian psychoanalysis and Ernesto Laclau’s theory, the pandemic is conceptualised as an ‘imaginary dislocation’. This analytical device is deployed to examine the author’s scenes of reading and writing during the first year of his PhD in the UK. By conceptualising the pandemic as an imaginary dislocation, the interpretation focuses on the unconscious content repressed in both scenes as an indicator of the struggles to endure in his academic identity vis-à-vis the erosion of his imaginary of the university. In order to capture this messy, elusive content, the interpretation relies on the idea of the tremor. Emerging incessantly in the author’s readings during the pandemic, the tremor is explored here as a trope staging, in unison, unconscious encounters, a trait of the author’s identity and a metaphor of the pandemic. Therefore, by both advancing a conceptual proposal and interpreting an empirical case, the article seeks to contribute to the understanding of how the pandemic has affected the imaginary frameworks within which our symbolic identifications find stability.
Thickness measurement method for self-supporting film with double chromatic confocal probes
Authors: Li Jiafu , Zhu Xiaoping , Du Hua , Ji Zhengchao , Wang Kai , Zhao Mo
Published: October 2021

With the randomness and immeasurability properties of zero point, the conventional
self-supporting film thickness measurement model must calibrate the
distance between two chromatic confocal sensors using a standard part
whose thickness needs to be measured by other methods in advance. The
measurement performance is easily disturbed by the calibration
process, and by the accuracy of sample thickness or its uniformity. In
order to overcome these limitations, a new thickness measurement model
was developed by adding an auxiliary transparent film in the initial
position of the dispersion field. The lower plane of the reference
film is not only applied as the zero point of the first sensor but
also can be measured by another sensor, whose value is equal to the
sensor distance. Theoretical analysis and simulation showed that the
proposed method does not change the linear relationship of the
displacement coefficient. In order to verify the proposed measurement
model, a laboratory thickness measurement system was developed based
on two commercial chromatic confocal sensors with a displacement
accuracy less than 0.2 µm. A set of self-supporting film was measured
using the proposed system, the traditional method, and the reference
system. These experiments indicated that the standard deviation of the
calibration results of the sensor distance based on the proposed
method was reduced to 0.1 µm, which can be concluded that its
stability was improved significantly compared to the conventional
model. In addition, the proposed method was able to achieve a
measurement accuracy of 0.4 µm, which can demonstrate its efficiency
and practicability.
Sensorless astigmatism correction using a variable cross-cylinder for high lateral resolution optical coherence tomography in a human retina
Authors: Tamura Masato , Moriguchi Yoshikiyo , Yeh Shu-Yun , Matsumoto Akiko , Shibutani Masahiro , Asao Takahiro , Mino Toshihiro , Nakanishi Michiko , Kubota Atsushi , Akiba Masahiro
Published: October 2021

High lateral resolution (

∼
5

µ

m

) optical coherence tomography (OCT) that employs a variable cross-cylinder (VCC) to compensate for astigmatism is presented for visualizing minute structures of the human retina. The VCC and its sensorless optimization process enable ocular astigmatism correction of up to

−

5.0

diopter within a few seconds. VCC correction has been proven to increase the signal-to-noise ratio and lateral resolution using a model eye. This process is also validated using the human eye by visualizing the capillary network and human cone mosaic. The proposed method is applicable to existing OCT, making high lateral resolution OCT practical in clinical settings.
Supply chain coordination strategy for NEVs based on supplier alliance under dual-credit policy
Authors: Ma Miaomiao , Meng Weidong , Li Yuyu , Huang Bo
Published: October 2021

In this paper, we assume that the supply chain for new energy vehicles (NEVs) consists of a manufacturer and N parts suppliers, considering that the R&D investment of both manufacturer and suppliers will affect the market demand of NEVs and NEVs credit, we construct decentralized and centralized decision-making models under the dual-credit policy to study the R&D investment strategy of supply chain enterprises. Furthermore, considering that suppliers can form alliances, we establish bargaining game models under the conditions of the non-alliance and alliance of suppliers, and discuss the coordination strategy for the NEVs supply chain. It is found that, under the dual-credit policy, the higher the credit coefficient of technology improvement, the higher the transaction price of credits, and the higher the R&D investment of supply chain. Dual-credit policy can effectively encourage NEVs supply chain to increase R&D investment, improve NEV technology level, and improve the profit of supply chain. Under the dual-credit policy, the increment profit distribution strategy based on a bargaining game model can coordinate the NEVs supply chain. When suppliers separately negotiate with the manufacturer, bringing the negotiation sequence forward, the supplier can get more profits. However, as the manufacturer has the right to determine the negotiation sequence, the supplier can only get the profit of the last round of negotiation, and the manufacturer can get excess profit. Forming a suppliers alliance can solve this problem effectively, and increase the profit of all suppliers when the alliance`s negotiating power is improved to a certain threshold.
Detours increase local knowledge—Exploring the hidden benefits of self-control failure
Authors: Wiesner Christian Dirk , Meyer Jennifer , Lindner Christoph
Published: October 2021

Self-control enables people to override momentary thoughts, emotions, or impulses in order to pursue long-term goals. Good self-control is a predictor for health, success, and subjective well-being, as bad self-control is for the opposite. Therefore, the question arises why evolution has not endowed us with perfect self-control. In this article, we draw some attention to the hidden benefits of self-control failure and present a new experimental paradigm that captures both costs and benefits of self-control failure. In an experiment, participants worked on three consecutive tasks: 1) In a transcription task, we manipulated how much effortful self-control two groups of participants had to exert. 2) In a number-comparison task, participants of both groups were asked to compare numbers and ignore distracting neutral versus reward-related pictures. 3) After a pause for recreation, participants were confronted with an unannounced recognition task measuring whether they had incidentally encoded the distracting pictures during the previous number-comparison task. The results showed that participants who exerted a high amount of effortful self-control during the first task shifted their priorities and attention toward the distractors during the second self-control demanding task: The cost of self-control failure was reflected in worse performance in the number-comparison task. Moreover, the group which had exerted a high amount of self-control during the first task and showed self-control failure during the second task was better in the unannounced third task. The benefit of self-control failure during number comparison was reflected in better performance during the recognition task. However, costs and benefits were not specific for reward-related distractors but also occurred with neutral pictures. We propose that the hidden benefit of self-control failure lies in the exploration of distractors present during goal pursuit, i.e. the collection of information about the environment and the potential discovery of new sources of reward. Detours increase local knowledge.
Induction of mitochondria mediated apoptosis in human ovarian cancer cells by folic acid coated tin oxide nanoparticles
Authors: Hanna Demiana H. , R. Saad Gamal
Published: October 2021

Purpose

This study aims to prepare folic acid coated tin oxide nanoparticles (FA-SnO2 NPs) for specifically targeting human ovarian cancer cells with minimum side effects against normal cells.

Methods

The prepared FA-SnO2 NPs were characterized by FT-IR, UV-vis spectroscopy, XRD, SEM and TEM. The inhibition effects of FA-SnO2 NPs against SKOV3 cancer cell were tested by MTT and LDH assay. Apoptosis induction in FA-SnO2 NPs treated SKOV3 cells were investigated using Annexin V/PI, AO/EB and Comet assays and the possible mechanisms of the cytotoxic action were studied by Flow cytometry, qRT-PCR, Immunohistochemistry, and Western blotting analyses. The effects of FA-SnO2 NPs on reactive oxygen species generation in SKOV3 cells were also examined. Additionally, the safety of utilization FA-SnO2 NPs were studied in vivo using Wister rats.

Results

The obtained FA-SnO2 NPs displayed amorphous spherical morphology with an average diameter of 157 nm and a zeta potential value of -24 mV. Comparing to uncoated SnO2 NPs, FA-SnO2 NPs had a superior inhibition effect towards SKOV3 cell growth that was suggested to be mediated through higher reactive oxygen species generation. It was showed that FA-SnO2 NPs increased significantly the % of apoptotic cells in the sub- G1 and G2/M phases with a higher intensity comet nucleus in SKOV3 treated cells. Furthermore, FA-SnO2 NPs was significantly increased the expression levels of P53, Bax, and cleaved Caspase-3 and accompanied with a significant decrease of Bcl-2 in the treated SKOV3 cells.

Conclusion

Overall, the results suggested that an increase in cellular FA-SnO2 NPs internalization resulted in a significant induced cytotoxicity in SKOV3 cancer cells in dose-dependent mode through ROS-mediated cell apoptosis that may have occurred through mitochondrial pathway. Additionally, the results confirmed the safety of utilization FA-SnO2 NPs against living systems. So, FA-SnO2 NPs with a specific targeting moiety may be a promising therapeutic candidate for human ovarian cancer.
El Movimiento Europeo y las asociaciones juveniles: de los orígenes de la relación a la Campaña Europea de la Juventud (1948-1958)
Authors: Martín de la Guardia Ricardo , Pérez Sánchez Guillermo Á.
Published: October 2021

La actividad en pro del europeísmo por parte de los responsables del Movimiento europeo en los años de la inmediata posguerra fue constante. En estos primeros momentos del proceso de integración europea el interés por difundir entre la nuevas generaciones de europeos los valores de la integración económica y política (estrechamente relacionados con la educación y la cultura) condujeron hasta la organización de la Campaña Europea de la Juventud», desarrollada a lo largo de buena parte de la década de los cincuenta. El origen de la iniciativa surgió de los contactos establecidos en los últimos años cuarenta –después de la celebración del Congreso de La Haya– entre personalidades comprometidas con el ideal europeísta y las agrupaciones juveniles. En definitiva, el vasto programa diseñado tenía como objetivo  crear en la juventud una conciencia europeísta y lograr su apoyo para las embrionarias instituciones de integración
Reavivar la llama. Salvador de Madariaga y la renovación del liberalismo (1945-1962)
Authors: Domínguez Castro Luis , Rodríguez Lago José Ramón
Published: October 2021

Este artículo centra su estudio en el papel jugado por Salvador de Madariaga en el seno de dos de las principales redes transnacionales que abogaron por promocionar los postulados liberales tras la Segunda Guerra Mundial. La Internacional Liberal y la Mont Pèlerin Society nacieron casi al unísono en la Europa de la posguerra como herederas de los debates y las redes surgidas en los años treinta. Entre 1945 y 1962 Madariaga se entregó a la causa reavivar la llama de un liberalismo sofocado por los totalitarismos y la deriva intervencionista de los estados-nación. Su actividad en ambos organismos permite profundizar en la compresión de las redes personales, intelectuales y financieras que condicionaron la trayectoria del liberalismo en las décadas centrales del siglo XX.
La diplomacia comercial francesa en Galicia: en busca de un mercado para la sal (1722-1735)
Authors: García Hurtado Manuel Reyes
Published: October 2021

Una de las principales tareas encomendadas a los cónsules era la de auspiciar, favorecer, proteger y fomentar el comercio de sus naciones en el territorio en que desempeñaban su cargo. Jean-Baptiste Dauvergne durante los años en que fue cónsul general de Galicia y sus puertos tuvo como principal objetivo comercial lograr que los administradores de la renta de la sal en Galicia otorgaran su preferencia a la sal producida en Francia (concretamente en Bretaña) frente a la portuguesa. Analizamos la labor que llevó a cabo para alcanzar su propósito a través de las relaciones que estableció en Galicia, presentando los obstáculos que debió sortear, tanto para lograr abrir este mercado como para atraer a los productores bretones, las características que tuvo este tráfico y su debilidad intrínseca.
A construção da ideia de números racionais a partir da divisão contínua do resto
Authors: Ribeiro Soares Rama Bárbara , Deptula Pereira Larissa Helena , Sumadossi Cunha Alexandra
Published: October 2021

Este trabalho apresenta, à luz da Teoria das Situações Didáticas e por meio da pesquisa-ação, o registro e a análise de situações-problema propostas a alunos do 4o ano do Ensino Fundamental com o intuito de investigar se a divisão sucessiva do resto se mostra potente na compreensão da ideia de números racionais. Visando contribuir com a Didática da Matemática, discutem-se potenciais estratégias para que a compreensão da ideia dos números racionais seja mais naturalizada, e não contraposta aos conhecimentos sobre os números naturais.
Análise do emprego do Método de Preocupação Compartilhada (Método Pikas) em uma situação de maus-tratos entre pares
Authors: Rodrigo Pereira Veras Daniel , Bozza é Pedagoga Thais
Published: October 2021

O Método de Preocupação Compartilhada, desenvolvido pelo pesquisador Anatol Pikas, é indicado para intervir nas situações de violência entre pares (bullying). Este relato de experiência tem como objetivo analisar e discutir a aplicabilidade do Método a partir do registro de uma situação ocorrida entre jovens de 13 e 14 anos. Foram elaboradas duas categorias de análise para avaliar o emprego do procedimento: estrutura física e pessoal da instituição participante e a atuação do mediador. A análise realizada indica uma correspondência parcial entre as etapas do Método e a ação desenvolvida. Enfatizamos que, à luz dos estudos em educação moral, esse método é indicado como intervenção ao bullying.
Educação e Cultura: o não-reconhecimento do trabalho do mediador cultural
Authors: Da Silva Cintia Maria
Published: October 2021

Neste artigo, pretendemos apresentar algumas ideias gerais que constituem o trabalho do/a mediador/a cultural e sua contribuição para uma educação crítica e emancipadora. Como ação educativa, sua atuação pretende construir conhecimento, estimulando a leitura, a reflexão e a interpretação do universo cultural de referência. Contudo, essa ocupação tem seu potencial sucateado e invisibilizado por meio de práticas neoliberais que precarizam as relações e condições de trabalho, ferindo suas possibilidades de criticidade e planejamento. Elaborar caminhos para o reconhecimento e a inserção dessa atividade trabalhista na Classificação Brasileira de Ocupações (CBO) parece ser o próximo passo na luta trabalhista desta categoria.